bluuebunny/crossref_metadata_2025_split huggingface dataset:
Медицинская карикатура в русском и арабском языках: общее и специфическое
Authors: Дугалич Н.М. 
Published: February 2025

Карикатура на медицинскую тему на русском языке является одним из самых распространенных комических текстов в интернет-коммуникации. Это объясняется сложившимися в русской культуре традициями осмысления существующих проблем через их высмеивание. Для арабской традиции карикатура может быть оценена как достаточно новое явление, начавшееся с карикатуры политического дискурса и появившиеся в результате влияния европейской традиции. Сопоставительное исследование карикатуры на русском и арабском языках показало, что в их основе лежат общие тенденции и принципы, что объясняет совпадение в их тематике и инструментарии изобразительного ряда. Лингвоспецифическими чертами являются обращение к теме диабета, отсутствие стигмы в обсуждении сферы психиатрии, включение в визуальный ряд традиционной одежды и предметов быта в арабской карикатуре и преемственность графическим традициям карикатуры советской школы, обращение к прецедентным феноменам и к теме алкогольной зависимости в медицинской карикатуре на русском языке.
A caricature on a medical topic in Russian is one of the most common comic texts in Internet communication. This is explained by developed in Russian culture traditions of understanding existing problems through ridicule. For the Arab tradition, caricature can be assessed as a fairly new phenomenon, which began with the caricature of political discourse and appeared as a result of the influence of the European tradition. A comparative study of caricatures in the Russian and Arabic languages showed that they are based on common trends and principles, which explains the coincidence in their themes and visual tools. Linguistic specific features are the appeal to the topic of diabetes, the absence of stigma in the discussion of psychiatry, the inclusion of traditional clothing and household items in the visual range in the Arabic caricature and the continuity of the graphic traditions of the Soviet school caricature, the appeal to precedent phenomena and the topic of alcohol addiction in the medical caricature in Russian.
Peering into the Black Box: Forward Modeling of the Uncertainty Budget of High-resolution Spectroscopy of Exoplanet Atmospheres
Authors: Savel Arjun B. , Bedell Megan , Kempton Eliza M.-R. , Smith Peter C. B. , Bean Jacob L. , Zhao Lily L. , Wong Kaze W. K. , Sanchez Jorge A. , Line Michael R. 
Published: February 2025

Abstract
Ground-based high-resolution cross-correlation spectroscopy (HRCCS; R ≳ 15,000) is a powerful complement to space-based studies of exoplanet atmospheres. By resolving individual spectral lines, HRCCS can precisely measure chemical abundance ratios, directly constrain atmospheric dynamics, and robustly probe multidimensional physics. But the subtleties of HRCCS data sets—e.g., the lack of exoplanetary spectra visible by eye and the statistically complex process of telluric removal—can make interpreting them difficult. In this work, we seek to clarify the uncertainty budget of HRCCS with a forward-modeling approach. We present an HRCCS observation simulator, scope,5

5

https://github.com/arjunsavel/scope

that incorporates spectral contributions from the exoplanet, star, tellurics, and instrument. This tool allows us to control the underlying data set, enabling controlled experimentation with complex HRCCS methods. Simulating a fiducial hot Jupiter data set (WASP-77Ab emission with IGRINS), we first confirm via multiple tests that the commonly used principal component analysis does not bias the planetary signal when few components are used. Furthermore, we demonstrate that mildly varying tellurics and moderate wavelength solution errors induce only mild decreases in HRCCS detection significance. However, limiting-case, strongly varying tellurics can bias the retrieved velocities and gas abundances. Additionally, in the low signal-to-noise ratio limit, constraints on gas abundances become highly non-Gaussian. Our investigation of the uncertainties and potential biases inherent in HRCCS data analysis enables greater confidence in scientific results from this maturing method.
Exploring the efficacy of AMACR, ERG, and AR immunostains in prostatic adenocarcinoma and their association with novel grade groups
Authors: Andarawi Mohamed O. , Otifi Hassan , Hassan Hesham , Yousif Adil A. , Mustafa Saadalnour A. , Elsiddig Shawgi A. , Babker Asad Ma , Ali Elryah I. , Elhag Omer Osman 
Published: February 2025

The study examines the utility of AMACR, ERG, and AR immunostains in diagnosing prostatic adenocarcinoma (PCa) and assessing prognosis in comparison to the Gleason score and new WHO grading groups. Seventeen PCa biopsies and five benign prostatic hyperplasia (BPH) biopsies were analyzed. Immunoreactivity, scored from 1 to 3 based on percentage of positive cells and intensity of expression, was assessed, revealing 76.47% positivity for AMACR, 35.29% for ERG, and 94.12% for AR in PCa cases, with variable scores and intensity among markers and grade groups. AMACR sensitivity and ERG specificity were noted. Higher-grade PCa exhibited increased positivity for both markers, indicating prognostic significance. In BPH cases, AMACR showed positivity in 2 cases, ERG in 1, and AR in all cases, albeit with lower expression. Differential expression was observed among immunomarkers and grade groups of malignancy. AMACR and ERG stains serve as sensitive and specific markers for PCa diagnosis and prognosis. Their increasing positivity with higher-grade groups underscores prognostic value. These findings highlight the importance of immunostains in refining PCa diagnosis and prognostication.
Towards an approach for enhancing water security: The case of South Africa
Authors: Mokone Neo W. , Gumede Vusi 
Published: February 2025

Background: Water demands in South Africa are rising, yet there is a lack of frameworks addressing sustainable water security at the local level. This gap, compounded by limited empirical evidence, challenges efforts to enhance water security.Aim: The article assesses water security and proposes a localised and adaptive framework for long-term water security at the household level in South Africa, aligning with sustainable development and integrated water resource management principles.Methods: Fieldwork, based on mixed methods approach, was conducted and a review of relevant literature was undertaken to identify fundamental dimensions of water security.Results: Critical elements influencing water security (viz. grouped into five dimensions: economic, social, technical, environmental, and institutional) were observed. An approach, based on the critical elements pertaining to water security, was developed to address the relevant dimensions, offering an integrated approach to enhancing water security.Conclusion: The proposed framework advances an understanding of water security by offering a novel and actionable approach that can be adapted to local contexts in South Africa (and possibly in other countries too). It emphasises the importance of multi-dimensional solutions to enhance the resilience of local water supply systems.Contribution: This article fills a significant gap in local-level water security frameworks, providing a practical model for policymakers and stakeholders to implement sustainable water security strategies in South Africa.
Reproducibility Issues in Cancer Research: A Compendious Study
Authors: Bhar Sunandita , Kabi Bikash , Kar Kanisha , Das Tanima , Ghosh Diya , Chandra Arpita 
Published: February 2025

Abstract
Scientific advances depend on the robust and reliable knowledge that serves as a solid foundation for further development. Currently, we are in the arena of unprecedented scientific publications in the field of cancer biology. However, unfortunately, the inability to reproduce the findings has been a long-standing problem and is a matter of serious concern. Compelling evidence suggests that, this irreproducibility of basic and preclinical research is mostly a result of the failure of good scientific practice by multi-stakeholders. It is high time to endorse a multipronged approach to address this concern. In this review, we have discussed the burning problems related to the reproducibility of findings in cancer research. Since, no single solution will suffice, herein we tried to put forth some of the probable approaches that may help to improve research qualities as well as reproducibility.
Glucocorticoid Receptor Interacts with B-cell Lymphoma 2 for Domineering Aggressiveness of Breast Cancer: An Observational Study
Authors: Thakur Debanjan , Kar Shinjini , Sengupta Debomita , Chakrabarti Jayanta , Sen Sagar , Roy Arindam , Mahapatra Elizabeth , Das Salini , Mukherjee Sutapa 
Published: February 2025

Abstract

Background:
Steroid hormone receptors (HRs) such as estrogen receptor/progesterone receptor are routinely used for stratifying breast cancer (BC) patients during endocrine-targeted therapy, except triple-negative BCs which lack these receptors. Thus, probing for alternative steroid HRs with prognostic value in BC is necessary. Glucocorticoid receptor (GR), another steroid HR, associated with prosurvival has been known to be prognostic in breast carcinoma, although studies in the Indian patients’ cohort are scanty. Antiapoptotic protein B-cell lymphoma 2, (Bcl-2) being positively associated with GR, is also known to have a significant influence on BC progression, but its exact role is paradoxical.

Aim and Objective:
This study aimed to look into the expressional status of GR in the Indian BC patients’ cohort to understand the molecular basis of its association with Bcl-2 to provide a basis for the prognostic value of Bcl-2 and its impact on clinicopathological parameters related to disease progression. This study was conducted in the BC patient cohort (n = 15) of all molecular subtypes visiting hospital outpatient department.

Materials and Methods:

In silico data mining, flow cytometry, enzyme-linked immunosorbent assay, immunoblotting, and co-immunoprecipitation were performed to analyze for subsequent observations. Pearson correlation analysis and Chi-squared tests were performed to derive the statistically relevant findings.

Results:
GR is co-expressed with Bcl-2 in the concerned cohort, and participates in protein-protein interactions subsequently sustaining its expression and supplementing to aggressiveness of the disease.

Conclusion:
GR/Bcl-2 interaction in preliminary findings demanded further extensive research to establish GR and Bcl-2 as promising targets in BC.
Targeting Cancer Stem Cells by Natural Compounds in Combination with Conventional Chemotherapy: An Ideal Strategy for Combating Cancer Recurrence
Authors: Ghosh Rituparna , Biswas Souradeep , Samanta Priya , Sarkar Rupali , Pakhira Shampa , Mondal Mrinmoyee , Bhowmik Arijit , Hajra Subhadip , Saha Prosenjit 
Published: February 2025

Abstract
Conventional chemotherapy, one of the foremost types of cancer treatment, usually displays satisfactory efficacy in the initial stages. However, lots of patients suffer from drug resistance as well as cancer relapse which are two major hindrances in cancer treatment. The main culprit behind these two barriers is cancer stem cells (CSCs). CSCs, a small subpopulation within the tumor, have self-renewal properties. Besides, this population is responsible for metastasis, angiogenesis, and other hallmarks of cancer. CSCs are able to escape the drug insults provided by synthetic conventional therapeutics. On the other hand, natural compounds are showing enough potential to eradicate CSCs in tumors. Along with this, the combination of natural and synthetic compounds has more efficacies to control both proliferating cancer cells as well as CSCs. These therapeutic combinations significantly downregulate various CSC markers and molecular pathways that play crucial roles in the enrichment of CSCs in vitro and in vivo. In this review, we provide brief descriptions about some natural compounds which are potent CSC-targeting agents when used as monotherapy or combinatorial therapy. This review focuses on the combinatorial therapy of natural and synthetic compounds which can provide new therapeutics for cancer treatment in near future.
The Role of Parental Depression on Adolescent Depression in Indonesia
Authors: Mubasyiroh Rofingatul , Suryaputri Indri Yunita , Putri Alifa Syamantha , Setiyawati Diana , Irmansyah  , Suparmi  , Sulistiyowati Ning , Lasut Doni , Oktarina  
Published: February 2025

Abstract

Introduction:
Depression is one form of common mental disorder that significantly impacts adolescents. The emotional well-being of parents and family can directly influence adolescents’ mental states. This study aimed to assess the association between parental depression and adolescents aged 15–19 years.

Methods:
This study utilized data from the third, fourth, and fifth cycles of the Indonesian Family Life Survey (IFLS) conducted jointly by Research and Development Corporation and Universitas Gadjah Mada. Adolescent depression was assessed using the Center for Epidemiologic Studies Depression-10, in which IFLS-5 (2014) data were analyzed. At the same time, parental depression was measured using data from IFLS-4 (2007) and IFLS-5 (2014). The study sample consisted of adolescents living with their parents, and 1104 adolescents were involved in the analysis. A multivariate logistic regression model of potentially contributing factors was employed to analyze the role of parental depression in adolescent depression.

Results:
A substantial portion of adolescents (21.2%) reported experiencing depression, with a higher prevalence observed among girls (25.3%). Adolescents were more likely to experience depression if their parents also reported depressive symptoms. According to 2014 data, as many as 25.4% of adolescents with mothers experiencing depression also reported feeling depressed. Meanwhile, 28.1% of adolescents experienced depression at the same time that their fathers felt depressed. Parental depression affected adolescent depression and had a significant and greater effect on female adolescents.

Conclusion:
This study revealed a strong association between parental depression and adolescent depression in Indonesia. The results underscore the importance of family-based interventions to reduce the adverse effects of depression on adolescents.
Síndrome de Wells com manifestação atípica
Authors: Castro Natália Tebas de , Oiniz Lucia Martins Oiniz , Bortolini Bruna dos Anjos , Fraga Rafael Cavanellas , Busatto Shimena Guisso Cabral 
Published: February 2025

Introdução: A Síndrome de Wells é dermatose eosinofílica, benigna, rara. Classicamente, manifesta-se por quadro súbito e recorrente de placa eritematosa infiltrada nos membros. Lesão pápulonodular é incomum, assim como sinais sistêmicos. O diagnóstico é clínico e histopatológico. Relata-se apresentação atípica da Síndrome de Wells, tornando-se um desafio diagnóstico. Objetivo: Destacar a importância do conhecimento das formas atípicas e suspeição clínica, para que o diagnóstico não seja retardado. Relato de caso: Homem, 39 anos, apresentando quadro cutâneo súbito e recorrente há 13 anos. Iniciava por vesículas e bolhas associadas à febre e artralgia, evoluindo para pápulas e nódulos dolorosos, que drenavam secreção serossanguinolenta nos membros e tronco. Os exames demonstraram eosinofilia e fator reumatoide positivo. A histopatologia revelou infiltrado eosinofílico denso na derme e áreas de degeneração eosinofílica do colágeno (figuras em chama), características da Síndrome de Wells. Conclusão: O caso demonstra lesões pápulonodulares, forma atípica, cujo diagnóstico foi auxiliado pela histopatologia característica e a eosinofilia periférica. Destaca-se a importância do seguimento do paciente, já que pode ser desencadeada por doenças mieloproliferativas.
A Systematic Literature Review of Post-Positivism and Critical Realism as Epistemological Frameworks in Educational Research
Authors: Fodouop Kouam Arthur William 
Published: February 2025

This study conducts a systematic literature review to examine the potential of post-positivism and critical realism as epistemological frameworks for enhancing educational research. By employing a rigorous methodology that involves explicit inclusion and exclusion criteria, comprehensive data extraction, and thematic analysis, the study synthesizes existing literature to elucidate the theoretical foundations and methodological implications of these paradigms. The originality of this research lies in its focused exploration of how these frameworks can address the current limitations in educational inquiry, particularly regarding the need for a deeper understanding of causal mechanisms and contextual influences. The findings underscore the significance of clarifying epistemological assumptions, adopting methodological pluralism, and promoting reflexivity in educational research. Additionally, the study provides practical recommendations for researchers seeking to apply these frameworks in their work effectively. By bridging the existing knowledge gap, this research aims to inspire future investigations and foster deeper insights into the complexities of educational contexts.

Received: 14 September 2024 | Revised: 28 November 2024 | Accepted: 14 January 2025

Conflicts of Interest
The author declares that he has no conflicts of interest to this work.

Data Availability Statement
Data sharing is not applicable to this article as no new data were created or analyzed in this study.

Author Contribution Statement
Fodouop Kouam Arthur William: Conceptualization, Methodology, Software, Validation, Formal analysis, Investigation, Resources, Data curation, Writing - original draft, Writing - review & editing, Visualization, Supervision, Project administration.
Pengaruh Daun Pandan Wangi (Pandanus Ammarylifollius Roxb) sebagai Kosmetik Hair Tonic untuk Perawatan Rambut Berketombe
Authors: Zahra Zegita  , Merita Yanita  
Published: February 2025

This research is motivated by scalp and hair disorders that affect beauty. Hair is generally considered a crown for every woman. One of the issues with the scalp and hair is dandruff. The factors causing dandruff include poor hair hygiene and the use of inappropriate hair cosmetics. Therefore, there needs to be an alternative to reduce dandruff, such as using hair tonic. The purpose of this study is to analyze a hair tonic made from pandan leaves with treatment frequencies of once a day and twice a day for two weeks.This type of research employs a quasi-experimental method. The design used is a Non-equivalent Control Group. The population for this study consists of women aged 19-24, specifically students from the Class of 2020 in Beauty and Makeup, with a sample size of 6. The data collection techniques include observation and documentation. The data analysis techniques used are normality tests, homogeneity tests, and t-tests. Based on the research results, the use of hair tonic made from pandan leaves (Pandanus amaryllifolius Roxb) as a cosmetic hair tonic for treating dandruff shows that in the indicator of the amount of flakes/dandruff, the treatment of once a day resulted in an average category of 5 (no flakes) while the treatment of twice a day resulted in an average category of 4 (significant reduction in dandruff). The average results indicate that the once-a-day hair tonic treatment is more effective in reducing dandruff.
Analisis Perilaku Hidup Bersih dan Sehat (PHBS) di PAUD Desa Somolo-Molo Kecamatan Somolo-Molo Kabupaten Nias
Authors: Niat Desita Sari Lawolo  , Rizki Ramadhani  
Published: February 2025

This study aims to analyze clean and healthy living behavior (PHBS) in PAUD Somolo-molo Village. The type of research used is qualitative descriptive. This research was carried out at PAUD Somolo-molo Village which was carried out for 2 months from July to August 2024 to be precise. The subjects of this research include school principals and educators as well as early childhood students of Somolo-molo Village. The object of the research was clean and healthy living behavior (PHBS) in PAUD Somolo-molo Village. The instruments used in this study are observation sheets and observations, interviews and documentation. The data analysis techniques used are data reduction, data presentation and conclusion or verification. The results of the research carried out are Clean and Healthy Living Behavior (PHBS) in PAUD Somolo-molo Village, Somolo-molo District, Nias Regency has implemented part of PHBS, namely washing hands with soap with running water, at mealtime the teacher looks at the provisions brought by the children so that the results are obtained that there are still children who do not consume healthy food and prefer snacks and or other ready-to-eat drinks, urinate (BAK) and defecate (FEC) in the latrine, then dispose of garbage in its place that has been provided in the classroom and outside the classroom.
Analisis Kecerdasan Musikal Anak Usia Dini dalam Kegiatan Bermain Drum Band di TK Negeri Alternatif Balige
Authors: Basha Gratia Simarmata  , Anada Leo Virganta  
Published: February 2025

This research uses qualitative methods. The aim of this qualitative research is to explain the musical intelligence of young children when playing drumband at the Balige Alternative Kindergarten. This research involved three teacher trainers and twenty early childhood children at Alternafif Balige Kindergarten. This research uses observation and interviews to collect data, and then carries out data analysis such as collecting, reducing, conveying, and drawing conclusions. The results of the research show that the musical intelligence of young children at the Balige Alternative Kindergarten develops well during drum band playing activities.
Meningkatkan Perkembangan Motorik Halus Anak dengan Kegiatan Menulis pada Usia 5-6 Tahun di Tk Negeri Pembina Gorontalo
Authors: Sri Muliyana Taha  , Siti Endang  , Siti Magfira Biludi  , Siti Fadilah Tahir  , Annisa Fahmi Mannassai  , Sri Yulan Umar  
Published: February 2025

The purpose of this study was to determine The Improvement of Fine Motor Development of Children Aged 5-6 Years Through WritingActivitiesat TK Negeri Gorontalo Thisresearchis Classroom Action Research (CAR) whichconsists of II Cycles starting with the stages of Planning, Implementation, Observation and Reflection. Data collectiontechniques are Observation, Documentation and Assessmentinstrumentsheet. The subjects in this study were 10 childrenaged 5 -6 yearsat TK Negeri Gorontalo. The study results showed that writing activities improve children's fine motor developmentat Tk Negeri Gorontalo. Itwasproven by the data In firstcycleitwasfoundthat 1 child (10%) with the criteria of Very Good Development (BSB), 5children (50%) with the criteria of Developing as Expected (BSH), 3 children (30%) with the criteria of Starting to Develop (MB) and 1 children (10%) with criteria not yetdeveloped (BB). While in the secondcycletherewasanincrease, namely 8 children (80%) with verygooddevelopmentcriteria (BSB) and 2 children (20%) developingaccording to expectations (BSH). In the secondcycle, itwasfoundthat the results of this study had reached the indicator of success of 80% with anassessmentcategory were 76% of the number of children. So it can be concluded that writing activities in Pembina State Kindergarten can improve the fine motor development of children aged 5 - 6 years.

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