bluuebunny/crossref_metadata_2025_split huggingface dataset:
Knowledge, attitudes and practice on sudden infant death: study protocol of a scoping review
Authors: Rodrigues Larissa , De Souza Ariane Vitória , del Risco Sánchez Odette , Carmona Elenice Valentim 
Published: May 2024

IntroductionSudden infant death syndrome (SIDS) is the unexpected death of an infant less than 1 year old, which occurs without presentation of any signs of mortality risk and it is not explained even after investigation, necropsy and review of the site of death. The nurse is an essential healthcare professional working with children and families who can contribute to preventing avoidable deaths of infants. Because SIDS is preventable, permanent education of the healthcare team, family members and infant caregivers is necessary.ObjectiveTo explore the scientific literature about knowledge, attitudes and practice on SIDS.Methods and analysisA scoping review will be conducted. Quantitative or qualitative primary studies, theses, dissertations and technical and governmental documents in English, Spanish, French or Portuguese will be considered, without a time limit for selection with search, in the databases: Pubmed, Embase, Scopus, Virtual Health Library, Digital Library of Theses and Dissertations of the Brazilian Institute and Cochrane. A search strategy will be elaborated with the keywords in the following themes: knowledge, attitudes, practice, sudden infant death and healthcare. The eligibility criteria will be applied to references of selected articles to identify new studies. The studies selected will be subjected to thematic content analysis, which allows data interpretation through a systematic classification process for coding themes to the analysis of quantitative and qualitative studies and meta-aggregation. NVIVO V.14 software will be used to organise, code and validate the data.Ethics and disseminationEthics approval is not required. The results will be disseminated to the health science community through professional networks, conference presentations and publication in a scientific journal.
Understanding patterns of fatigue in health and disease: protocol for an ecological momentary assessment study using digital technologies
Authors: Adam Rosalind , Lotankar Yojana , Sas Corina , Powell Daniel , Martinez Veronica , Green Stephen , Cooper Jonathan , Bradbury Katherine , Sive Jonathan , Hill Derek L 
Published: May 2024

IntroductionFatigue is prevalent across a wide range of medical conditions and can be debilitating and distressing. It is likely that fatigue is experienced differently according to the underlying aetiology, but this is poorly understood. Digital health technologies present a promising approach to give new insights into fatigue.The aim of this study is to use digital health technologies, real-time self-reports and qualitative interview data to investigate how fatigue is experienced over time in participants with myeloma, long COVID, heart failure and in controls without problematic fatigue. Objectives are to understand which sensed parameters add value to the characterisation of fatigue and to determine whether study processes are feasible, acceptable and scalable.Methods and analysisAn ecological momentary assessment study will be carried out over 2 or 4 weeks (participant defined). Individuals with fatigue relating to myeloma (n=10), heart failure (n=10), long COVID (n=10) and controls without problematic fatigue or a study condition (n=10) will be recruited. ECG patches will measure heart rate variability, respiratory rate, body temperature, activity and posture. A wearable bracelet accompanied by environment beacons will measure physical activity, sleep and room location within the home. Self-reports of mental and physical fatigue will be collected via smartphone app four times daily and on-demand. Validated fatigue and affect questionnaires will be completed at baseline and at 2 weeks. End-of-study interviews will investigate experiences of fatigue and study participation. A feedback session will be offered to participants to discuss their data.Data will be analysed using multilevel modelling and machine learning. Interviews and feedback sessions will be analysed using content or thematic analyses.Ethics and disseminationThis study was approved by the East of England—Cambridge East Research Ethics Committee (22/EE/0261). The results will be disseminated in peer-reviewed journals and at international conferences.Trial registration numberNCT05622669.
Impact of social determinants of health on progression from potentially life-threatening complications to near miss events and death during pregnancy and post partum in a middle-income setting: an observational study
Authors: Keepanasseril Anish , Pal Koustav , Maurya Dilip Kumar , Kar Sitanshu Sekhar , Bakshi Ravleen , D’Souza Rohan 
Published: May 2024

ObjectiveTo assess the potential associations between social determinants of health (SDH) and severe maternal outcomes (SMO), to better understand the social structural framework and the contributory, non-clinical mechanisms associated with SMO.Study designProspective observational study.Study settingTertiary referral centre in south-eastern region of India.ParticipantsOne thousand and thirty-three women with potentially life-threatening complications (PLTC) were identified using WHO criteria.Risk factors assessedSocial Determinants of Health (SDH).Primary outcomesSevere maternal outcomes, which include maternal near-miss and maternal death.Statistical analysisLogistic regression to assess the association between SDH and clinical factors on SMO, expressed as adjusted ORs (aOR) with a 95% CI.ResultsOf the 37 590 live births, 1833 (4.9%) sustained PLTC, and 380 (20.7%) developed SMO. Risk of SMO was higher with increasing maternal age (adjusted OR (aOR) 1.04 (95% CI 1.01 to 1.07)), multiparity (aOR 1.44 (1.10 to 1.90)), medical comorbidities (aOR 1.50 (1.11 to 2.02)), obstetric haemorrhage (aOR 4.63 (3.10 to 6.91)), infection (aOR 2.93 (1.83 to 4.70)), delays in seeking care (aOR 3.30 (2.08 to 5.23)), and admissions following a referral (aOR 2.95 (2.21 to 3.93)). SMO was lower in patients from socially backward community (aOR 0.45 (0.33 to 0.61)), those staying more than 10 km from hospital (aOR 0.56 (0.36 to 0.78)), those attending at least four antenatal visits (aOR=0.53 (0.36 to 0.78)) and those referred from resource-limited facilities (aOR=0.62 (0.46 to 0.84)).ConclusionThis study demonstrates the independent contribution of SDH to SMO among those sustaining PLTC in a middle-income setting, highlighting the need to formulate preventive strategies beyond clinical considerations.
How does communication affect patient safety? Protocol for a systematic review and logic model
Authors: Howick Jeremy , Bennett-Weston Amber , Solomon Josie , Nockels Keith , Bostock Jennifer , Keshtkar Leila 
Published: May 2024

IntroductionOne in 10 patients are harmed in healthcare, more than three million deaths occur annually worldwide due to patient safety incidents, and the economic burden of patient safety incidents accounts for 15% of hospital expenditure. Poor communication between patients and practitioners is a significant contributor to patient safety incidents. This study aims to evaluate the extent to which patient safety is affected by communication and to provide a logic model that illustrates how communication impacts patient safety.Methods and analysisWe will conduct a systematic review of randomised and non-randomised studies, reported in any language, that quantify the effects of practitioner and patient communication on patient safety. We will search MEDLINE, CINAHL, APA PsychINfo, CENTRAL, Scopus and ProQuest theses and dissertations from 2013 to 7 February 2024. We will also hand-search references of included studies. Screening, data extraction and risk of bias assessment will be conducted by two independent reviewers. Risk of bias will be assessed using the Cochrane Risk of Bias in Non-Randomised Studies of Interventions (ROBINS-I) for non-randomised studies, and the Cochrane Risk of Bias V.2 (RoB2) for randomised controlled trials. If appropriate, results will be pooled with summary estimates and 95% confidence intervals (CIs); otherwise, we will conduct a narrative synthesis. We will organise our findings by healthcare discipline, type of communication and type of patient safety incident. We will produce a logic model to illustrate how communication impacts patient safety.Ethics and disseminationThis systematic review does not require formal ethics approval. Findings will be disseminated through international conferences, news and peer-reviewed journals.PROSPERO registration numberCRD42024507578.
Meta-Analysis of Genome-Wide Association Studies Reveals Genetic Mechanisms of Supraventricular Arrhythmias
Authors: Weng Lu-Chen , Khurshid Shaan , Hall Amelia Weber , Nauffal Victor , Morrill Valerie N. , Sun Yan V. , Rämö Joel T. , Beer Dominik , Lee Simon , Nadkarni Girish , Johnson Renee , Andreasen Laura , Clayton Anne , Pullinger Clive R. , Yoneda Zachary T. , Friedman Daniel J. , Hyman Matthew C. , Judy Renae L. , Skanes Allan C. , Orland Kate M. , Jordà Paloma , Treu Timothy M. , Oetjens Matthew T. , Subbiah Rajesh , Hartmann Jacob P. , May Heidi T. , Kane John P. , Issa Tariq Z. , Nafissi Navid A. , Leong-Sit Peter , Dubé Marie-Pierre , Roselli Carolina , Choi Seung Hoan ,   FinnGen, Million Veteran Program, Regeneron Genetics Center, Tardif Jean-Claude , Khan Habib R. , Knight Stacey , Svendsen Jesper H. , Walker Bruce , Karlsson Linnér Richard , Gaziano J. Michael , Tadros Rafik , Fatkin Diane , Rader Daniel J. , Shah Svati H. , Roden Dan M. , Marcus Gregory M. , Loos Ruth J.F. , Damrauer Scott M. , Haggerty Christopher M. , Cho Kelly , Palotie Aarno , Olesen Morten S. , Eckhardt Lee L. , Roberts Jason D. , Cutler Michael J. , Shoemaker M. Benjamin , Wilson Peter W.F. , Ellinor Patrick T. , Lubitz Steven A. 
Published: May 2024

BACKGROUND:
Substantial data support a heritable basis for supraventricular tachycardias, but the genetic determinants and molecular mechanisms of these arrhythmias are poorly understood. We sought to identify genetic loci associated with atrioventricular nodal reentrant tachycardia (AVNRT) and atrioventricular accessory pathways or atrioventricular reciprocating tachycardia (AVAPs/AVRT).

METHODS:
We performed multiancestry meta-analyses of genome-wide association studies to identify genetic loci for AVNRT (4 studies) and AVAP/AVRT (7 studies). We assessed evidence supporting the potential causal effects of candidate genes by analyzing relations between associated variants and cardiac gene expression, performing transcriptome-wide analyses, and examining prior genome-wide association studies.

RESULTS:

Analyses comprised 2384 AVNRT cases and 106 489 referents, and 2811 AVAP/AVRT cases and 1,483 093 referents. We identified 2 significant loci for AVNRT, which implicate
NKX2-5
and
TTN
as disease susceptibility genes. A transcriptome-wide association analysis supported an association between reduced predicted cardiac expression of
NKX2-5
and AVNRT. We identified 3 significant loci for AVAP/AVRT, which implicate
SCN5A
,
SCN10A
, and
TTN/CCDC141
. Variant associations at several loci have been previously reported for cardiac phenotypes, including atrial fibrillation, stroke, Brugada syndrome, and electrocardiographic intervals.

CONCLUSIONS:
Our findings highlight gene regions associated with ion channel function (AVAP/AVRT), as well as cardiac development and the sarcomere (AVAP/AVRT and AVNRT) as important potential effectors of supraventricular tachycardia susceptibility.
Technical and Clinical Outcomes After Transcatheter Edge‐to‐Edge Repair of Mitral Regurgitation in Male and Female Patients: Is Equality Achieved?
Authors: Biasco Luigi , Tersalvi Gregorio , Klersy Catherine , Benfari Giovanni , Biaggi Patric , Corti Roberto , Curti Moreno , Gaemperli Oliver , Jeger Raban , Maisano Francesco , Mueller Olivier , Naegeli Barbara , Noble Stephane , Praz Fabien , Toggweiler Stefan , Valgimigli Marco , Cristoforetti Yvonne , Enriquez‐Sarano Maurice , Pedrazzini Giovanni 
Published: May 2024

Background
Currently, no clear impact of sex on short‐ and long‐term survival following transcatheter edge‐to‐edge mitral valve repair (TEER) is evident, although no data are available on postprocedural life expectancy. Our aim was to assess sex‐specific differences in outcomes of patients with mitral regurgitation (MR) treated by TEER.

Methods and Results

Short‐term and 5‐year outcomes in men and women undergoing TEER between 2011 and 2018 who were included in the large, multicenter, real‐world MitraSwiss registry were analyzed. Outcomes were compared stratified by sex and according to MR cause (primary versus secondary). The impact of TEER on postprocedural life expectancy was estimated by relative survival analysis. Among 1142 patients aged 60 to 89 years, 39.8% were women. They were older, with fewer cardiovascular risk factors and lower functional capacity compared with men. Thirty‐day mortality was higher in men than in women (3.3% versus 1.1%; odds ratio, 3.16 [95% CI, 1.16–10.7];
P
=0.020). Five‐year survival was comparable in both sexes (adjusted hazard ratio for 5‐year mortality in men, 1.14 [95% CI, 0.90–1.44],
P
=0.275). Both men and women with either primary or secondary MR showed similar clinical efficacy over time. TEER provided high relative survival estimates among all groups, and fully restored predicted life expectancy in women with primary MR (5‐year relative survival estimate, 97.4% [95% CI, 85.5–107.0]).

Conclusions
TEER is not associated with increased short‐term mortality in women, whereas 5‐year outcomes are comparable between sexes. Moreover, TEER completely restored normal life expectancy in women with primary MR. A residual excess mortality persists in secondary MR, independently of sex.
Falsehood and False Prophets in Jeremiah
Authors: Koralija Srećko 
Published: May 2024

Abstract
This article explores the use of שֶׁקֶר in MT-Jer, and the manner in which the Septuagint (LXX) and Peshitta (P) read it. In that regard, the article also discusses lying, falsehoods (ψευδής, ψεῦδος, ἄδικος, µάτη, ܫܘܩܪܐ, ܕܓܠܘܬܐ), and false prophets (ψευδοπροφήτης, ܢܒܝܐ ܕܓܠܐ) in LXX and P. As such, it pioneers the examination of P-Jer’s perspective on false prophets. The article demonstrates that the translators of LXX and P approached the Hebrew source text in a manner that was not strictly literal, aligning with the nuances of the target language. It is argued that both LXX-Jer and P-Jer illuminate the polysemy inherent in the Hebrew lexeme שֶׁקֶר. In addition, both versions demonstrate a degree of textual liberty and interpretative renderings. Finally, the article demonstrates that unlike LXX, which labels Hananiah as a false prophet only once (LXX-Jer 35:1), P systematically designates him so throughout P-Jer 28. Consequently, the article also adds weight to the argument opposing a direct textual influence of LXX on P.
Can video streaming improve first aid for injured patients? A prospective observational study from Norway
Authors: Idland Siri , Kramer-Johansen Jo , Bakke Håkon Kvåle , Hagen Milada , Tønsager Kristin , Platou Hans-Christian Stoud , Hjortdahl Magnus 
Published: May 2024

Abstract
Background
Video streaming in emergency medical communication centers (EMCC) from caller to medical dispatcher has recently been introduced in some countries. Death by trauma is a leading cause of death and injuries are a frequent reason to contact EMCC. We aimed to investigate if video streaming is associated with recognition of a need for first aid during calls regarding injured patients and improve quality of bystander first aid.

Methods
A prospective observational study including patients from three health regions in Norway, from November 2021 to February 2023 (registered in clinical trials 10/25/2021, NCT05121649). Cases where video streaming had been used as a supplement during the medical emergency call were compared to cases where video streaming was not used during the call. Patients were included by ambulance personnel on the scene of accident if they met the following criteria: 1. Ambulance personnel arrived at a patient who had an injury, 2. One or more bystanders had been present before their arrival, 3. One or more of the following first aid measures had been performed by bystander or should have been performed: airway management, control of external bleeding, recovery position, and hypothermia prevention. Ambulance personnel assessed quality of first aid performed by bystander, and information concerning use of video streaming and patient need for first aid measures recognized by dispatcher was collected through EMCC audio logs and patient charts. We present descriptive data and results from a logistic regression analysis.

Results
Data was collected on 113 cases, and dispatchers used video streaming in addition to standard telephone communication in 12/113 (10%) of the cases. The odds for the dispatcher to recognize a need for first aid during a medical emergency call were more than five times higher when video streaming was used compared to no use of video streaming (OR 5.30, 95% CI 1.11-25.44). Overall quality of bystander first aid was rated as “high”. The odds ratio for the patient receiving first aid of higher quality were 1.82 (p-value 0.46) when video streaming was used by dispatcher during the call.

Conclusion
Our findings show that video streaming is not frequently used by dispatchers in calls regarding patients with injuries, but that video streaming is associated with improved recognition of patients’ first aid needs. We found no statistically significant difference in first aid quality comparing the calls where video streaming as a supplement were used with the calls with audio only.
Safety profiles of offspring born from early-follicular long-acting GnRH agonist protocol and daily mid-luteal GnRH agonist protocol: a retrospective study
Authors: Du Linqing , Song Jianyuan , Fan Wenqian , Ye Tian , Kong Huijuan 
Published: May 2024

Abstract
Background
The gonadotropin hormone-releasing hormone agonists (GnRH-a) have been widely used for controlled ovarian stimulation in assisted reproductive technology (ART). The early-follicular long-acting GnRH-a long protocol (EFL) and the luteal phase short-acting GnRH-a long protocol (LPS) are commonly used GnRH agonist protocols. We conducted a retrospective analysis to assess and compare the rates of congenital abnormalities and safety profiles in offspring born from the EFL and LPS protocols.

Methods
We conducted a retrospective cohort study to analyze and compare neonatal data from patients who using EFL or LPS protocols at our center between January 1, 2014, and June 30, 2017. The study ultimately included 1810 neonates from 1401 cycles using the EFL protocol and 2700 neonates from 2129 cycles using the LPS protocol.The main outcome measures are gestational age at delivery, birth weight, and congenital anomaly rate.To assess the influence of various factors on congenital abnormalities, a random-effects logistic regression model was employed.

Results
The EFL and LPS protocols led to similar congenital anomaly rates (1.64% vs. 2.35%, P = 0.149). No significant differences were found between the two groups regarding birth weight and its categories, newborn gender and congenital anomaly rate. The results of the multivariate logistic regression model indicated no association between congenital anomaly and BMI, duration of infertility, treatment protocol, fertilization method, or embryo transfer stage. Compared with singleton pregnancies, the probability of congenital defects in multiple pregnancies was 2.64 times higher (OR: 2.64, 95% CI: 1.72–4.05, P < 0.0001). Newborns with congenital defects were born with a lower gestational age compared with full-term pregnancies.

Conclusion
In conclusion, the EFL protocol is considered a safe option for ensuring offspring safety, comparable with the LPS protocol; however, multiple pregnancies represent an independent risk factor for congenital abnormalities. This approach can be widely adopted; however, prioritizing single embryo transfers is strongly recommended to minimize the potential risks associated with multiple pregnancies in offspring.
Bilateral optic nerve infiltration and leukemic retinopathy as initial signs of leukemia relapse with central nervous system involvement in an adult: a case report
Authors: Wang Yisai , Zhu Ling , Wang Hongtao , Li Zhen , Bai Ruomeng , Wei Qinghua , Huang Lin , Xu Ying , Li Songguo , Chen Hui 
Published: May 2024

Abstract
Background
We describe a case in which bilateral optic nerve infiltration and leukemic retinopathy were the initial signs of disease relapse in a patient with Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+-ALL) with central nervous system (CNS) involvement.

Case presentation
A 65-year-old Asian female with Ph+-ALL in complete remission presented at our institution with symptoms of visual disturbance, central scotoma and pain with eye movement in both eyes for a 1-month duration. Ophthalmic examination revealed remarkable optic disc swelling with multiple flame-shaped peripapillary hemorrhages, retinal venous dilation and retinal hemorrhages in both eyes. She was subsequently referred to the treating oncologist and diagnosed with Ph+-ALL relapse with multiple relapsed diseases involving the bone marrow and CNS. After intrathecal (IT) therapy, her visual acuity dramatically improved, and her leukemic infiltrates decreased.

Conclusions
To the best of our knowledge, this is the first case report of ALL relapse with CNS involvement presenting as bilateral optic nerve infiltration and leukemic retinopathy in an adult. Hence, we highlight the priority and sensitivity of ophthalmic examinations, as they are noninvasive methods for detecting leukemia relapse.