bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sublethal propoxur toxicity to juvenile common carp (Cyprinus carpio L., 1758): biochemical, hematological, histopathological, and genotoxicity effects
Authors: Gül Ali , Benli A. Çağlan Karasu , Ayhan Ayşen , Memmi Burcu Koçak , Selvi Mahmut , Sepici-Dinçel Aylin , Çakiroğullari Gül Çelik , Erkoç Figen 
Published: June 2012

Abstract
The sublethal toxicological and genotoxic potential of propoxur, a widely used carbamate insecticide against household pests, in veterinary medicine, and in public health, was evaluated on carp as a model species (Cyprinus carpio L., 1758) using the erythrocyte micronucleus test. Based on the 96-h lethal concentration, 50% (LC50) data from the U.S. Environmental Protection Agency ECOTOX Database (10 mg/L), a sublethal exposure concentration of 5 mg/L was used under static bioassay laboratory conditions. Histopathological evaluation showed no significant changes in spleen, intestine, muscle, or skin tissues. However, the following conditions were recorded: hyperemia, branchitis in primary lamella, and telangiectasis, hyperplasia, fusion, epithelial lifting, and epithelial desquamation in secondary lamella of gill tissues; hemorrhage, destruction, prenephritis, and inflammation and desquamation in the tubules; edema in the kidney; passive hyperemia, albumin, and hydropic degeneration in the liver; and hyperemia, chromatolysis, and glial proliferation in brain tissues. No statistically significant increases in micronuclei frequencies were found. Hematological parameters showed decreased hematocrit values and mean corpuscular volume values, as well as increased erythrocyte and leukocyte counts compared with the control group (p &lt; 0.01). Plasma glucose, cholesterol, triglycerides, phosphorus, sodium, total plasma protein, chloride, and aspartate aminotransferase levels were increased (p &lt; 0.01). Only plasma calcium and potassium levels decreased in the experimental group. Propoxur has an ecotoxicological potential on fish, a nontarget organism. Environ. Toxicol. Chem. 2012; 31: 2085–2092. © 2012 SETAC
Multidisciplinary therapy consisting of minimally invasive resection, irradiation, and intra‐arterial infusion of 5‐fluorouracil for maxillary sinus carcinomas
Authors: Nishino Hiroshi , Takanosawa Minako , Kawada Kazumi , Kanazawa Takeharu , Ichimura Keiichi , Takahashi Satoru , Nakazawa Masanori 
Published: June 2012

AbstractBackgroundCurrent goals for the treatment of maxillary sinus carcinoma include the preservation of vision, eating, communication, and appearance, as well as the achievement of a cure.MethodsJapanese patients (n = 121) with maxillary sinus carcinoma were analyzed retrospectively. All patients underwent multidisciplinary therapy including minimally invasive resection, 20 Gy irradiation, and intra‐arterial infusion of 5‐fluorouracil.ResultsThe 5‐ and 10‐year overall survival rates were 73% and 68%, respectively. In 97 patients with squamous cell carcinoma (SCC), the 5‐ and 10‐year overall survival rates were 76% and 70%, respectively. All 29 patients with orbital invasion retained the orbital contents, and 21 of these patients demonstrated adequate visual acuity. There were 16 complications, including trismus (5 patients), double vision (5 patients), fistula formation (3 patients), and cataract (3 patients).ConclusionA multidisciplinary therapy, consisting of minimally invasive resection, irradiation, and regional chemotherapy, can yield good patient prognosis and quality of life after treatment. © 2012 Wiley Periodicals, Inc. Head Neck, 2012
Emerging understanding of dosimetric factors impacting on dysphagia and nutrition following radiotherapy for oropharyngeal cancer
Authors: Cartmill Bena , Cornwell Petrea , Ward Elizabeth , Davidson Wendy , Nund Rebecca , Bettington Catherine , Rahbari Reza Masoud , Poulsen Michael , Porceddu Sandro 
Published: June 2012

AbstractBackgroundResearch has reported relationships between 3‐dimensional (3D) radiation dose to head and neck structures and consequential swallowing/nutritional outcomes. However, this evidence is preliminary. The current study aimed to identify which reported dose constraints identified functional impairment at 6 months posttreatment.MethodsDose constraints with reported relationships to swallowing and nutrition were identified through a systematic literature review. Dose–volume histograms for 12 patients with T1–T3 oropharyngeal cancer treated with 3D conformal radiotherapy determined dosages delivered to specific structures. Doses were examined in relation to published dose constraints and the swallowing and nutritional outcomes at 6 months posttreatment.ResultsIn all, 66% of the reported mean, maximum, and partial doses to 8 structures correctly identified swallowing and nutrition outcomes at 6 months.ConclusionThe relationships observed between known dosimetric constraints and functional outcomes highlight the potential for dosimetric data to assist in prognosis and treatment. Systematic research is required to refine dosimetric parameters and the impact on functional outcomes. © 2012 Wiley Periodicals, Inc. Head Neck, 2013
Predictive value of metastatic cervical lymph node ratio in papillary thyroid carcinoma recurrence
Authors: Yip Jonathan , Orlov Steven , Orlov David , Vaisman Alon , Hernández Karen Gómez , Etarsky Daniel , Kak Ipshita , Parvinnejad Nikoo , Freeman Jeremy L. , Walfish Paul G. 
Published: June 2012

AbstractBackgroundThe purpose of this study was to determine whether the proportion of metastatic cervical lymph nodes resected (metastatic lymph node ratio [MLNR]) predicted papillary thyroid carcinoma (PTC) recurrence, and whether MLNR could alter the predictive ability of TNM nodal classification for recurrence in PTC.MethodsWe conducted a retrospective review of patients with PTC who underwent a total or near‐total thyroidectomy with at least 1 lymph node removed at our institution.ResultsOf 253 patients, 35 (13.8%) developed recurrent disease. The total MLNR (ratio between total metastatic lymph nodes and total number of lymph nodes resected) independently predicted PTC recurrence (odds ratio [OR], 1.024; 95% confidence interval [CI], 1.010–1.039; p = .001). In receiver operating characteristic (ROC) curve analysis, TNM nodal classification with total MLNR had greater accuracy in predicting PTC recurrence than did TNM nodal classification alone (0.726 and 0.675, respectively).ConclusionMLNR is an independent predictor of PTC recurrence and enhances the predictive value of TNM nodal classification. © 2012 Wiley Periodicals, Inc. Head Neck, 2013
Golgi complex fragmentation in G2/M transition: An organelle‐based cell‐cycle checkpoint
Authors: Corda Daniela , Barretta Maria Luisa , Cervigni Romina Ines , Colanzi Antonino 
Published: June 2012

AbstractIn mammalian cells, the Golgi complex is organized into a continuous membranous system known as the Golgi ribbon, which is formed by individual Golgi stacks that are laterally connected by tubular bridges. During mitosis, the Golgi ribbon undergoes extensive fragmentation through a multistage process that is required for its correct partitioning into the daughter cells. Importantly, inhibition of this Golgi disassembly results in cell‐cycle arrest at the G2 stage, suggesting that accurate inheritance of the Golgi complex is monitored by a “Golgi mitotic checkpoint.” Here, we discuss the mechanisms and regulation of the Golgi ribbon breakdown and briefly comment on how Golgi partitioning may inhibit G2/M transition. © 2012 IUBMB IUBMB Life, 64(8): 661–670, 2012
Metformin reverses hexokinase and phosphofructokinase downregulation and intracellular distribution in the heart of diabetic mice
Authors: Da Silva Daniel , Ausina Priscila , Alencar Edgard M. , Coelho Wagner S. , Zancan Patricia , Sola‐Penna Mauro 
Published: June 2012

AbstractDiabetes mellitus is characterized by hyperglycemia and its associated complications, including cardiomyopathy. Metformin, in addition to lowering blood glucose levels, provides cardioprotection for diabetic subjects. Glycolysis is essential to cardiac metabolism and its reduction may contribute to diabetic cardiomyopathy. Hexokinase (HK) and phosphofructokinase (PFK), rate‐limiting enzymes of glycolysis, are downregulated in cardiac muscle from diabetic subjects, playing a central role on the decreased glucose utilization in the heart of diabetic subjects. Thus, the aim of this study was to determine whether metformin modulates heart HK and PFK from diabetic mice. Diabetes was induced by streptozotocin injection on male Swiss mice, which were treated for three consecutive days with 250 mg/kg metformin before evaluating HK and PFK activity, expression, and intracellular distribution on the heart of these subjects. We show that metformin abrogates the downregulation of HK and PFK in the heart of streptozotocin‐induced diabetic mice. This effect is not correlated to alteration on the enzymes' transcription and expression. However, the intracellular distribution of both enzymes is altered in diabetic hearts that show increased activity of the soluble fraction when compared to the particulate fraction. Moreover, this pattern is reversed upon the treatment with metformin, which is correlated with the effects of the drug on the enzymes activity. Altogether, our results support evidences that metformin alter the intracellular localization of HK and PFK augmenting glucose utilization by diabetic hearts and, thus, conferring cardiac protection to diabetic subjects. © 2012 IUBMB IUBMB Life, 64(9): 766–774, 2012
Doppler velocimetry of the orbital vessels in pregnancies complicated by preeclampsia
Authors: Matias Denise Silva , Costa Rigman Ferraz , Matias Bruno Silva , Cláudio Lemos Correia Luis 
Published: June 2012

AbstractHypertension is one of the most common clinical complications during pregnancy. Preeclampsia, in particular, still accounts for high maternal and fetal morbidity and mortality. Hemodynamic studies have shown that general arteriolar vasoconstriction, which leads to hypoperfusion of target organs, including the eye area, remains the most significant pathological change in preeclampsia. Color Doppler imaging is the most appropriate and the commonly used method for the study of ocular circulation, especially during pregnancy. It enables the visualization and flow measurement of retrobulbar blood vessels. The aim of this review is to evaluate studies that investigated the role of Doppler velocimetry of the maternal orbital vessels, especially the ophthalmic artery, as a tool for the differential diagnosis of hypertensive disorders of pregnancy, for the assessment of the degree and severity of preeclampsia, and for the prediction of these disturbances. The analysis of these studies indicates that the Doppler variables are accurate in the differential diagnosis of hypertensive disorders and in assessing the severity and progression of the preeclampsia and may also be useful markers in the treatment and management of pregnancy‐induced hypertension. We found no study evaluating the role of orbital vessels Doppler variables in predicting preeclampsia or in the prognosis of maternal‐fetal adverse events. © 2012 Wiley Periodicals, Inc. J Clin Ultrasound, 2012
Increased nerve vascularization detected by color doppler sonography in patients with ulnar neuropathy at the elbow indicates axonal damage
Authors: Frijlink Daphne W. , Brekelmans Geert J.F. , Visser Leo H. 
Published: June 2012

AbstractIntroduction: The aim of this study was to establish the prevalence of increased intraneural vascularization detected by ultrasonography (IVUS) in patients with ulnar neuropathy at the elbow (UNE) and to determine its relationship to clinical, ultrasonographic, and electrodiagnostic findings. Methods: High‐resolution ultrasonography and color Doppler imaging were performed in 137 patients with confirmed UNE, 24 patient controls, and 70 healthy controls (HCs). Results: IVUS was found in 21 (15%) of 137 patients with UNE, in 1 (4%) of 24 patient controls, and in 0 of 70 HCs (P = 0.001). Patients with IVUS were more likely to have severe weakness (P = 0.01), severe atrophy of ulnar‐innervated muscles (P = 0.008), axonal damage (P = 0.001), and more pronounced nerve enlargement (P = 0.03) than those without IVUS. Conclusions: IVUS in the ulnar nerve can be detected in patients with UNE and is associated with nerve enlargement and clinical and electrodiagnostic severity. In addition, IVUS is associated with axonal damage. Muscle Nerve, 2013
Transfer of normal S1 nerve root to reinnervate atonic bladder due to conus medullaris injury
Authors: Lin Haodong , Hou Chunlin 
Published: June 2012

AbstractIntroduction: Neurogenic bladder dysfunction after spinal cord injury (SCI) is a major medical and social problem. In this study we assessed the effectiveness of neurogenic bladder reinnervation in patients with SCI using a normal S1 nerve root. Methods: Nine patients with bladder dysfunction caused by injury to the low conus medullaris (S2–S5) underwent a novel surgical procedure in which the unilateral proximal end of the S1 ventral root (VR) was anastomosed to the distal end of the S2 and S3 VRs. Results: Seven patients regained satisfactory bladder control within 8–12 months after VR microanastomosis. The average residual urine volume decreased from 186.0 ± 35.0 ml to 43.0 ± 10.0 ml, and no urinary infections occurred. Conclusions: These results suggest the effectiveness of bladder innervation by S1 nerve transfer, which could provide a new approach for the reconstruction of atonic bladder function caused by low conus medullaris injuries. Muscle Nerve, 2013
Desiccation shrinkage of non‐clayey soils: multiphysics mechanisms and a microstructural model
Authors: Hu Liang Bo , Péron Hervé , Hueckel Tomasz , Laloui Lyesse 
Published: June 2012

SUMMARYAnalysis of macroscopic desiccation shrinkage experiments indicates that most, but not all of the shrinkage during drying occurs while soil is still saturated. Shrinkage practically ceases and air starts to penetrate the soil, when the water content is still quite high, for example, above 20% for the tested soils. The remaining, unsaturated drying process occurs with a much‐reduced shrinkage rate. In this context, we examine data of the pore system evolution as represented by the mercury porosimetry experimental results. The process is then modeled as a two‐stage process of deformation and evacuation of a two‐tube vessel system driven by the external evaporation flux. In the first stage, Poiseuille flow occurs through the vessels. The amount of water evaporated in this stage equals to the reduction of volume of the vessel through the deformation of its walls. This stage ends when a negative water pressure (suction) required to further deform the vessel reaches a critical value at which air enters the pore space. Two physical interpretation of such threshold are discussed. In the subsequent stage, evaporation proceeds with a receding liquid/vapor interface starting from the open end, incrementally emptying the vessel but with a marginal water flow and vessel deformation. The leading variables of the process are identified, and a quantifiable multiphysics meso‐scale scenario of models is established. Copyright © 2012 John Wiley & Sons, Ltd.
Dynamic mechanical properties and swelling of UV‐photopolymerized anionic hydrogels
Authors: Saunders Joseph Ryan , Moussa Walied 
Published: June 2012

AbstractThe tensile dynamic mechanical properties and weight degree of swelling for anionic 2‐hydroxyethyl methacrylate‐co‐acrylic acid hydrogels were observed. Fabrication parameters examined were UV‐photopolymerization exposure time, UV‐photopolymerization intensity, and weight percentage crosslinker. The environmental conditions tested were electrolyte compositions of 0.5 and 0.05 M potassium hydroxide under applied frequencies of 0.1, 1, or 10 Hz. The overall maximum and minimum storage modulus was 1.83 ± 0.18 MPa and 68.5 ± 7.2 kPa, respectively, loss modulus was 432 ± 63 and 7.67 ± 3.22 kPa, respectively, and weight degree of swelling was 14.27 ± 1.27 and 1.95 ± 0.33, respectively. The morphology of fabricated hydrogels was examined using scanning electron microscopy showing a range of porous structures over the fabrication and environmental conditions examined, accounting for the variation in mechanical properties. The properties examined are of interest to researchers fabricating, designing, or modeling active hydrogel‐based microfluidic components. © 2012 Wiley Periodicals, Inc. J Polym Sci Part B: Polym Phys, 2012
Recent developments in polymeric superoleophobic surfaces
Authors: Xue Zhongxin , Liu Mingjie , Jiang Lei 
Published: June 2012

AbstractThe construction and application of superoleophobic surfaces have aroused worldwide interest during the past few years. These surfaces are of great significance not only for fundamental research but also for various practical applications in self‐cleaning, oil‐repellent coatings, and antibioadhesion. The unique properties of polymers have made them one of the most important materials for constructing superoleophobic materials. This article reviews recent developments in the design, fabrication, and application of polymeric superoleophobic surfaces. © 2012 Wiley Periodicals, Inc. J Polym Sci Part B: Polym Phys, 2012
An advanced gas/vapor permeation system for barrier materials: Design and applications to poly(ethylene terephthalate)
Authors: Lee Jong Suk , Chandra Preeti , Burgess Steven K. , Kriegel Robert , Koros William J. 
Published: June 2012

AbstractA new gas/vapor mixture permeation system is described to investigate the effect of organic molecules on oxygen (O2) and carbon dioxide (CO2) transport in barrier materials. Methanol vapor was considered as a flavor simulant mainly because of its conveniently high diffusion coefficient, which makes the experimental time accessible. A highly accurate syringe pump was used to introduce a desired activity level of vapor into gas feed stream. Adsorption of methanol on high energy surfaces is carefully characterized to prevent underestimation of methanol permeability. A special permeation cell was also developed to study the effect of interacting vapors on O2 and CO2 transport in barrier materials. Systematic permeation measurements were conducted for binary and ternary gas/vapor permeation measurements (e.g., MeOH/O2 and O2/CO2/MeOH) to verify the feasibility of our new vapor/gas permeation system. © 2012 Wiley Periodicals, Inc. J Polym Sci Part B: Polym Phys, 2012
No change in [11C]CUMI‐101 binding to 5‐HT1A receptors after intravenous citalopram in human
Authors: Pinborg Lars H. , Feng Ling , Haahr Mette E. , Gillings Nic , Dyssegaard Agnete , Madsen Jacob , Svarer Claus , Yndgaard Stig , Kjaer Troels W. , Parsey Ramin V. , Hansen Hanne D. , Ettrup Anders , Paulson Olaf B. , Knudsen Gitte M. 
Published: June 2012

AbstractThe main objective of this study was to determine the sensitivity of [11C]CUMI‐101 to citalopram challenge aiming at increasing extracellular 5‐HT. CUMI‐101 has agonistic properties in human embryonic kidney 293 cells transfected with human recombinant 5‐HT1A receptors (Hendry et al. [2011] Nucl Med Biol 38:273–277; Kumar et al. [2006] J Med Chem 49:125–134) and has previously been demonstrated to be sensitive to bolus citalopram in monkeys (Milak et al. [2011] J Cereb Blood Flow Metab 31:243–249). We studied six healthy individuals. Two PET‐scans were performed on the same day in each individual before and after constant infusion of citalopram (0.15 mg/kg). The imaging data were analyzed using two tissue compartment kinetic modeling with metabolite corrected arterial input and Simplified Reference Tissue Modeling using cerebellum as a reference region. There was no significant difference in regional distribution volume or non‐displaceable binding potential values before and after citalopram infusion. The mean receptor occupancy was 0.03 (range −0.14 to 0.17). Our data imply that [11C]CUMI‐101 binding is not sensitive to citalopram infusion in humans. Synapse, 2012. © 2012 Wiley Periodicals, Inc.
Photosynthetic and wood anatomical responses of Tamarixafricana Poiret to water level reduction after short‐term fresh‐ and saline‐water flooding
Authors: Abou Jaoudé Renée , de Dato Giovanbattista , De Angelis Paolo 
Published: June 2012

AbstractIn the Mediterranean basin, Tamarix spp. constitute important populations along rivers and sea coasts, and might be primarily subjected to water level fluctuations and salinization, as a consequence of global climate change. Here, we analyze leaf gas exchange and xylem anatomy during a water level decrease below the soil surface after short‐term flooding with fresh‐ and saline‐water (200 mM) in order to predict Tamarixafricana Poiret responses under future environmental conditions. Fresh‐water level reduction negatively affected stomatal conductance (−56.3 %), but only when water decreased to the lowest level (15 cm below the soil surface). No effects on assimilation rates and xylem vessel dimensions occurred. Under saline conditions, the rate of the water level decrease was lower compared to the non‐saline treatment, as stomatal conductance was negatively affected by salinity (−59.5 %) and significantly declined over time. Moreover, decreases in mean xylem vessel area (−51.3 %), assimilation rates (−52.2 %) and stomatal conductance (−76.0 %) were also observed compared to the control, indicating both an osmotic stress and a toxic effect of NaCl on leaf gas exchange. These leaf responses were probably induced by greater belowground‐root salt absorption and transport compared to previous flooding conditions, as confirmed by the increase in salt excretion (+473.2 %). The results emphasize the survival risk of Tamarix spp. to water level variation under both saline and non‐saline conditions, and the need of management practices focused on the conservation of these populations.
Synergism and Performance Optimization in Liquid Detergents Containing Binary Mixtures of Anionic–Nonionic, and Anionic–Cationic Surfactants
Authors: Jadidi Nazanin , Adib Behrooz , Malihi Farrokh B. 
Published: June 2012

AbstractIn this paper evaluation of surface active and application properties in liquid detergent formulations containing binary mixtures of anionic–nonionic, and anionic–cationic surfactants is discussed. Surfactants used include: linear alkylbenzene sulfonate (LAS), alcohol ether sulfate (AES‐2EO), alcohol ethoxylate (AE‐7EO), lauryl dimethyl amine oxide, and alkyl hydroxyethyl dimethyl ammonium chloride (AHDAC). Surface active parameters relating to the effectiveness and efficiency of surface tension reduction were determined from the surface tension data. Non‐ideal solution theory was used to determine the degree of interactions between the two surfactants, and the conditions under which a mixture of two surfactants show synergism in surface active properties. Our data indicated that synergism in mixed surfactants increases with the degree of charge difference between the surfactants. In both mixed micelle and mixed monolayer formation, the degree of interactions between the two surfactants in the mixture increased in the following order: LAS/AE < AES‐2EO/amine oxide < AES‐2EO/AHDAC. This synergistic behavior as presented in this paper leads to unique application properties and improved performance in terms of foam volume, and soil removal which has applications in formulation of dishwashing liquids, and laundry detergents.