bluuebunny/crossref_metadata_2025_split huggingface dataset:
Phenylazomethine Dendrimers with Soft Aliphatic Units as Metal‐Storage Nanocapsules and Their Self‐Assembled Structures
Authors: Ochi Yousuke , Sakurai Kozue , Azuma Keisuke , Yamamoto Kimihisa 
Published: December 2010

AbstractNew dendritic poly(phenylazomethine)s (DPAs) with dodecyl end groups (C12DPA) have been synthesized. C12DPA showed stepwise radial complexation with metals as a metal‐storage nanocapsule. Through modification with dodecyl, the properties of environmental responsiveness and self‐assembly become apparent for C12DPA as a π‐conjugated soft material. The dodecyl‐modified DPAs (C12DPAG4) were synthesized up to the fourth generation dendrimer, for the first time, which is a nanocapsule with a basic atmosphere for metal complexes in a hydrophobic environment. In addition, we found a suitable structure and conditions for the fibrous self‐assembly of DPA through the precise design of its dendritic structure. C12DPA, with an asymmetric structure, showed a fibrous assembly by a solvent drop‐casting. The metal‐complexed C12DPA showed an assembly different from the fibrous one through metal complexation on DPA imines. Interestingly, the vesicular assembly structure of C12DPA has been observed by the complexation of CuCl2 in toluene. In this study, we investigated the unique properties of C12DPA as a novel π‐conjugated soft material.
ChemInform Abstract: PbO/PbF2 Flux Growth of YScO3 and LaScO3 Single Crystals — Structure and Solid‐State NMR Spectroscopy.
Authors: Balamurugan Sarkarainadar , Rodewald Ute Ch. , Harmening Thomas , van Wuellen Leo , Mohr Daniel , Deters Heinz , Eckert Hellmut , Poettgen Rainer 
Published: December 2010

AbstractWell‐shaped single crystals of the title compounds are obtained from the corresponding sesquioxides in PbO/PbF2 fluxes (1423—1573 K, 12 h).
ChemInform Abstract: Ln2(OH)4SO4·nH2O (Ln: Pr to Tb; n ≈ 2): A New Family of Layered Rare‐Earth Hydroxides Rigidly Pillared by Sulfate Ions.
Authors: Liang Jianbo , Ma Renzhi , Geng Fengxia , Ebina Yasuo , Sasaki Takayoshi 
Published: December 2010

AbstractThe title compounds precipitate from aqueous solutions of Ln2(SO4)3, Na2SO4, and hexamethylenetetramine (N2 atmosphere, reflux, 6 h).
ChemInform Abstract: Cyclic Carbonates as Sustainable Solvents for Proline‐Catalyzed Aldol Reactions.
Authors: Clegg William , Harrington Ross W. , North Michael , Pizzato Francesca , Villuendas Pedro 
Published: December 2010

AbstractEthylene and propylene carbonate are sustainable alternatives to conventional polar aprotic solvents such as DMF and DMSO and for chlorinated solvents in proline‐catalyzed aldol reactions.
ChemInform Abstract: Gold Catalysis: Tandem Reactions of Diyne—Diols and External Nucleophiles as an Easy Access to Tricyclic Cage‐Like Structures.
Authors: Hashmi A. Stephen K. , Buehrle Miriam , Woelfle Michael , Rudolph Matthias , Wieteck Marcel , Rominger Frank , Frey Wolfgang 
Published: December 2010

AbstractTreatment of diynediols of type (I) and (XII) with water and the Au catalyst results in new formation of tricyclic ketals such as (II), (X), and (XIII).
ChemInform Abstract: Formation of Quaternary Chiral Centers by N‐Heterocyclic Carbene—Cu‐Catalyzed Asymmetric Conjugate Addition Reactions with Grignard Reagents on Trisubstituted Cyclic Enones.
Authors: Kehrli Stefan , Martin David , Rix Diane , Mauduit Marc , Alexakis Alexandre 
Published: December 2010

AbstractThe carbene generated from NHC efficiently promotes the process.
ChemInform Abstract: Bis(allyl)ruthenium(IV) Complexes Containing Water‐Soluble Phosphane Ligands: Synthesis, Structure, and Application as Catalysts in the Selective Hydration of Organonitriles into Amides.
Authors: Cadierno Victorio , Diez Josefina , Francos Javier , Gimeno Jose 
Published: December 2010

AbstractThe new Ru complexes are highly efficient catalysts for the reaction.
ChemInform Abstract: Formal Nucleophilic Substitution of Bromocyclopropanes with Amides en route to Conformationally Constrained β‐Amino Acid Derivatives.
Authors: Prosser Anthony R. , Banning Joseph E. , Rubina Marina , Rubin Michael 
Published: December 2010

AbstractA wide range of trans‐β‐aminocyclopropane carboxylic acid derivatives is prepared with the highest yields being observed for the 4‐(trifluoromethyl)‐ or 3,5‐bis‐(trifluoromethyl) benzoic acid amides.
ChemInform Abstract: Synthesis of γ‐Functionalized Allyltrichlorosilanes and Their Application in the Asymmetric Allylation of Aldehydes.
Authors: Malkov Andrei V. , MacDonald Claire , Kocovsky Pavel 
Published: December 2010

AbstractIsomerically pure allylsilanes react with aldehydes in the presence of Lewis‐basic catalysts to produce the corresponding syn‐ and anti‐allylbromohydrins (III) and (V), respectively as single diastereomers.
ChemInform Abstract: Copper‐Catalyzed Rearrangement of (Z)‐Propynal Hydrazones via N—N Bond Cleavage.
Authors: Nakamura Itaru , Shiraiwa Naozumi , Kanazawa Ryo , Terada Masahiro 
Published: December 2010

AbstractA variety of β‐aminoacrylonitriles is prepared in the reaction, catalyzed by Cu(OAc)2, followed by the Z/E‐isomerization, induced by AcOH.
ChemInform Abstract: Octafluorocyclohexa Derivatives of [60]Fullerene: C60(C4F8)n (n = 2, 3, 4, and 6)
Authors: Gruzinskaya N. I. , Pimenova A. S. , Khavrel' P. A. , Sidorov L. N. , Kemnitz E. , Troyanov S. I. 
Published: December 2010

Abstractsynthesis and molecular structure of four new octafluorocyclohexa adducts
ChemInform Abstract: Synthesis of Highly Substituted Pyrroles via Nucleophilic Catalysis.
Authors: Ngwerume Simbarashe , Camp Jason E. 
Published: December 2010

AbstractThe procedure renders possible a convenient and regioselective access to 2,4‐disubstituted, 2,3,5‐trisubstituted and tetrasubstituted pyrrole structures as interesting pharmaceutical scaffolds.
ChemInform Abstract: PdII‐Catalyzed C—H Functionalization of Indoles and Pyrroles Assisted by the Removable N‐(2‐Pyridyl)sulfonyl Group: C2‐Alkenylation and Dehydrogenative Homocoupling.
Authors: Garcia‐Rubia Alfonso , Urones Beatriz , Gomez Arrayas Ramon , Carretero Juan Carlos 
Published: December 2010

AbstractThe introduction of N‐(2‐pyridylsulfonyl) group into indole derivatives allows for complete C‐2 regiocontrol in the Pd‐catalyzed alkenylation reaction with various terminal and internal olefins.
ChemInform Abstract: Organocatalytic Asymmetric Mannich‐Type Reaction of N‐Sulfonylimines with Isocyanoacetate Leading to Optically Active 2‐Imidazoline‐4‐carboxylates.
Authors: Zhang Zhen‐Wei , Lu Gui , Chen Miao‐Miao , Lin Ning , Li Yong‐Bo , Hayashi Tamio , Chan Albert S. C. 
Published: December 2010

AbstractThis reaction provides a convenient method to access various substituted 2‐imidazolines and related α,β‐diamino acids in high enantiomeric purities.
ChemInform Abstract: Cobalt‐Catalyzed Addition of Azoles to Alkynes.
Authors: Ding Zhenhua , Yoshikai Naohiko 
Published: December 2010

AbstractThe reaction is catalyzed by CoBr2 and a biphosphine ligand (DPEphos or Xantphos) and is promoted by TmsCH2MgCl in catalytic or stoichiometric amount to afford the heteroaromatic substituted alkenes with complete or excellent (E)‐selectivity.
ChemInform Abstract: A Bimetallic Aluminum(salen) Complex for the Synthesis of 1,3‐Oxathiolane‐2‐thiones and 1,3‐Dithiolane‐2‐thiones.
Authors: Clegg William , Harrington Ross W. , North Michael , Villuendas Pedro 
Published: December 2010

AbstractThe aluminum complex in combination with Bu4NBr efficiently promotes the reaction of monosubstituted and 1,2‐disubstituted oxiranes with CS2.
ChemInform Abstract: Chiral Bisguanidine‐Catalyzed Inverse‐Electron‐Demand Hetero‐Diels—Alder Reaction of Chalcones with Azlactones.
Authors: Dong Shunxi , Liu Xiaohua , Chen Xiaohong , Mei Fang , Zhang Yulong , Gao Bo , Lin Lili , Feng Xiaoming 
Published: December 2010

AbstractThe title reaction proceeds well over a wide range of substrates, affording chiral γ,δ‐unsaturated δ‐lactones containing a quaternary stereocenter in high yields.
ChemInform Abstract: An Efficient Preparation of Indolizines Through a Tandem Palladium‐Catalyzed Cross‐Coupling Reaction and Cycloisomerization.
Authors: Kim Hyunseok , Lee Kwangmoo , Kim Sunggak , Lee Phil Ho 
Published: December 2010

AbstractA convenient procedure is elaborated for the one‐pot synthesis of indolizines from readily available aryl iodides or triflates (I).
ChemInform Abstract: Room Temperature Acylketene Formation? 1,3‐Dioxin‐4‐ones via Silver(I) Activation of Phenylthioacetoacetate in the Presence of Ketones.
Authors: May Aaron E. , Hoye Thomas R. 
Published: December 2010

AbstractTreatment of thioacetoacetates with ketones in the presence of AgOCOCF3 allows a new and mild access to dioxinones like (III) and (V).
ChemInform Abstract: Palladium‐Catalyzed Regioselective C—H Bond ortho‐Acetoxylation of Arylpyrimidines.
Authors: Zheng Xiaojian , Song Bingrui , Xu Bin 
Published: December 2010

AbstractHigh monoselectivity, excellent functional group tolerance, and easy derivatization of the final products are features of this method.
ChemInform Abstract: Steamed Ginseng‐Leaf Components Enhance Cytotoxic Effects on Human Leukemia HL‐60 Cells.
Authors: Tung Nguyen Huu , Song Gyu Yong , Minh Chau Van , Kiem Phan Van , Jin Long Guo , Boo Hye‐Jin , Kang Hee‐Kyoung , Kim Young Ho 
Published: December 2010

AbstractGinsenoside SL1 (I), SL2 (II) and SL3 (III) are isolated from the heat‐processed leaves of Panax ginseng.
ChemInform Abstract: Glyoxyl Analogues of Indole Phytoalexins: Synthesis and Anticancer Activity.
Authors: Kutschy Peter , Sykora Andrej , Curillova Zuzana , Repovska Maria , Pilatova Martina , Mojzis Jan , Mezencev Roman , Pazdera Pavel , Hromjakova Tatiana 
Published: December 2010

AbstractA series of analogues of indole phytoalexins is prepared and evaluated for their anticancer activity.
ChemInform Abstract: Synthesis of Organosulfur Compounds Based on Cyclocondensation Reactions of 3‐Arylthio‐1‐silyloxy‐1,3‐butadienes and 1,3‐Bis(silyloxy)‐1,3‐butadienes.
Authors: Nawaz Muhammad , Sher Muhammad , Langer Peter 
Published: December 2010

AbstractReview: about 50 refs.
Thalamocortical pathway specialization for sound frequency resolution
Authors: Storace Douglas A. , Higgins Nathan C. , Read Heather L. 
Published: December 2010

AbstractCore auditory cortices are organized in parallel pathways that process incoming sensory information differently. In the rat, sound filtering properties of the primary (A1) and ventral (VAF) auditory fields are markedly different, yet both are core regions that by definition receive most of their thalamic input from the ventral nucleus (MGBv) of the medial geniculate body (MGB). For example, spike rate responses to sound intensity and frequency are more narrowly resolved in VAF vs. A1. Here we question whether there are anatomic correlates of the marked differences in response properties in these two core auditory fields. Combined Fourier optical imaging and multiunit recording methods were used to map tone frequency responses with high spatial resolution in A1, VAF, and neighboring cortices. The cortical distance representing a given octave was similar, yet response frequency resolution was about twice as large in VAF as in A1. Retrograde tracers were injected into low‐ and high‐isofrequency contours of both regions to compare MGBv label patterns. The distance between clusters of MGBv neurons projecting to low‐ and high‐isofrequency contours in the cortex was twice as large in caudal as in rostral MGB. This suggests that differences in A1 and VAF frequency resolution are related to the anatomic spatial resolution of frequency lamina in the thalamus, supporting a growing consensus that antecedents of cortical specialization can be attributed in part to the structural and functional characteristics of thalamocortical inputs. J. Comp. Neurol. 519:177–193, 2011. © 2010 Wiley‐Liss, Inc.
Assessing objective countertransference with a computer‐delivered impact message inventory (IMI‐C)
Authors: Hafkenscheid Anton 
Published: December 2010

AbstractThe circumplex version of the Impact Message Inventory (IMI‐C) is one of the few existing diagnostic devices for the assessment of ‘objective’ (inter‐subjective) countertransference. The IMI‐C purports to assess eight categories of countertransference reactions along the circumference of the interpersonal circle, conceptualized as blends of the two basic dimensions of affiliation (AFF) and control (CON): dominant (D), hostile‐dominant (HD), hostile (H), hostile‐submissive (HS), submissive (H), friendly‐submissive (FS), friendly (F) and friendly‐dominant (FD).As a measure of objective (or ‘inter‐subjective’) countertransference, a crucial test for the IMI‐C is its ability to produce scores that are generalizable across different therapists involved with the same patients. In four previous psychometric studies, the ‘objectivity’ of countertransference reactions was examined with a Dutch paper‐and‐pencil IMI‐C version. In the present study, the generalizability of countertransference reactions across therapists was tested with a computer‐delivered IMI‐C. Results obtained with the electronic IMI‐C format were compared with the findings of the paper‐and‐pencil version.Similar to the four prior studies, D and HD were the comparatively most generalizable classes of countertransference reactions among the eight categories. Both the AFF and CON main dimensions scores were substantially generalizable across therapists.From different perspectives of analysis, more favorable results were obtained with the computer‐delivered IMI‐C in comparison to the paper‐and‐pencil‐version for (a) five of the eight countertransference classes (D, HD, F, FS, FD) and also for (b) the AFF main dimension.The computer‐based IMI‐C appears to be a promising tool for assessing objective countertransference reactions. Copyright © 2010 John Wiley & Sons, Ltd.Key Practitioner Message:• Your countertransference reactions are likely to be partly patient‐induced (‘objective’).• Countertransference reactions can conveniently be classified in terms of the interpersonal circle.• The computer‐based IMI‐C is a user‐friendly clinical instrument for the assessment of patient‐induced countertransference reactions.
Psychotherapy across cultures: the form–content dichotomy
Authors: Jacob K. S. , Kuruvilla Anju 
Published: December 2010

AbstractThe diversity of patients, problems, beliefs and cultures mandates the need to educate, match, negotiate and integrate psychological interventions. This is necessary in all cultures and in every setting. Many schools of psychotherapy offer specific theories and particular techniques, yet they share many common approaches. Their individual techniques allow therapists form and structure to treat different clinical problems, discuss diverse content and use them in varied settings and among people with assorted cultural backgrounds. The heterogeneity within cultures, regions and populations demands that therapists understand the local and individual reality. The apparent contradictions between standard psychological therapies and their use across cultures, when viewed through a form–content framework, allow for matching strategies for specific individuals and their distress, and for choosing the best treatment options from a diverse therapeutic armamentarium. Psychotherapies are at their weakest when they attempt to provide explanations across cultures and are at their strongest when they are used as vehicles for engagement with patients. The challenge is to find a common psychotherapeutic language, which attempts to bridge the divide between the issues facing the patient and the armamentarium of the therapist. The form–content paradigm at least partly explains the complexity of the issues within psychotherapy. It also allows the therapist to move from the therapy‐centric orientation of Western approaches to the patient‐centric orientations required for success in psychological therapies. Copyright © 2010 John Wiley & Sons, Ltd.Key Practitioner Message:• The diversity of patients, problems, beliefs and cultures within countries mandates the need to educate, match, negotiate and integrate psychological interventions.• Specific psychotherapeutic frameworks allow therapists the structure to manage different clinical problems, discuss diverse content, and use it in varied settings and among people with assorted cultural backgrounds.• The form‐content dichotomy views psychotherapy as a vehicle for engagement, allows for matching strategies for specific individuals and their distress and permits therapists to move from the therapy‐centric orientation to a patient‐centric approach necessary for success in psychological intervention.
Growth of rhombohedral insulin crystals and in vitro modeling of their dissolution in the blood stream
Authors: Nanev C. N. , Dimitrov I. L. , Hodzhaoglu F. V. 
Published: December 2010

AbstractInsulin is the only protein that is secreted in a crystalline form in a human healthy body. To mimic the secretion process we used NaCl salting‐out to growing tiny rhombohedral Zn‐insulin crystals. The dissolution of the insulin crystals is of special interest for the therapeutical praxis, because the human body is supplied with the physiologically active monomers of the insulin through dissolution of the crystalline granules secreted in the pancreatic β‐cells. Sets of tiny rhombohedral Zn‐insulin crystals, which resembled the granules secreted in the β‐cells, were subjected to dissolution in blood plasma and model solutions. The impacts of the solution composition, flow rate, pH and ionic strength on the insulin crystal dissolution were investigated. The effect of the blood plasma was determinant because it dissolved the rhombohedral Zn‐insulin crystals almost instantly, while the effects of solution's physicochemical characteristics were of minor importance. In addition, we found that the presence of abundant zinc ions suppressed the dissolution of the insulin crystals. (© 2011 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Preparation of calcium sulfate whiskers using waste calcium chloride by reactive crystallization
Authors: Song Xingfu , Zhang Lina , Zhao Jingcai , Xu Yanxia , Sun Ze , Li Ping , Yu Jianguo 
Published: December 2010

AbstractCalcium sulfate whiskers, owing to its good thermal stability, chemical resistance and good compatibility with rubber and plastics, has a strong potential in the application of polymer reinforcing composite materials. This work deals with the preparation of calcium chloride whiskers by reactive crystallization process with sulfuric acid and calcium chloride discharged from Solvay process. Firstly, the orthogonal experiments were carried out using both CaCl2 and H2SO4 in analytic grade as feedstock, and the reactive crystallization conditions were optimized, which included reaction temperature, reactant concentration, reaction time and stirring speed. Based on the optimized reactive crystallization conditions, the new process for the preparation of calcium chloride whiskers was studied using the reactive crystallization process with sulfuric acid and calcium chloride discharged from Solvay process, and the effects of impurity ions in the waste solutions on the growth of whiskers were evaluated. It was found that calcium sulfate whiskers with stable and structured fine crystals (its aspect ratio up to 190) can be prepared using waste CaCl2 in Solvay process. The experimental results will provide the valuable information for the reasonable disposal of waste CaCl2 solution from Solvay process. (© 2011 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Cataloging the interactome of small molecules and the human proteome
Authors: Gurwitz David 
Published: December 2010

AbstractRecent advances in computational power permit accurate in silico predictions of the interactions between small molecules and protein targets. Countless studies have been published about such interactions and about computational tools for predicting drug—target interactions. What is still missing, and would greatly facilitate drug design and development, is a comprehensive and open database allowing the extraction of information on the predicted interactions (interactome) between small molecules and the human proteome. Ideally, such a catalog should include the entire repertoires of published small natural and synthetic compounds and each member of the human proteome. This would be a huge undertaking requiring massive public support. The PubChem database at the National Center for Biotechnology Information may serve as a fine starting point for embarking on such a massive project. Drug Dev Res 72: 1–3, 2011. © 2010 Wiley‐Liss, Inc.
Molecular simulations for the evaluation of binding free energies in lead optimization
Authors: Noy Efrat , Senderowitz Hanoch 
Published: December 2010

AbstractThe ability to predict, through computer simulation, the free energy of binding between drug‐like ligands and their biological target(s) is one of the most difficult yet rewarding tasks in computer‐aided drug design (CADD) efforts. Successful and consistent predictions are likely to have a profound effect on the efficiency of hit discovery and lead optimization campaigns. However, the route to achieving this goal is paved with challenges resulting from the complexity of the binding process and from the ability to simulate it, given contemporary computational tools. In this review we present the challenges faced by binding free energy simulations within the context of lead optimization, survey the main tools currently in use for performing such calculations, and discuss their applications and performance based on selected examples. Our main conclusion is that despite great progress and numerous success cases, free energy simulations have yet to mature in order to become an integral component of the arsenal of tools available to practitioners in the field of lead optimization. Drug Dev Res 72: 36–44, 2011. © 2010 Wiley‐Liss, Inc.
Machine learning in drug discovery and development
Authors: Wale Nikil 
Published: December 2010

AbstractIn‐silico tools and computational techniques have become an integral part of pharmaceutical research. These techniques are now used extensively at various phases during the drug development process. Such tools perform a wide range of functions from retrieving and analyzing data to sophisticated computational models for many biological and chemical processes in drug discovery. Among them, machine‐learning techniques are becoming especially popular because of their emphasis on obtaining accurate predictions. In this overview, we discuss the increasing role of Machine Learning in Drug Discovery. Since this field has close connections with the field of Statistics, we will first describe similarities and differences between these fields. We will then highlight various domains and problems within drug discovery that are utilizing machine‐learning technology to improve and speed up the drug discovery process. Drug Dev Res 72: 112–119, 2011.  © 2010 Wiley‐Liss, Inc.