bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sinus bone formation and implant survival after sinus membrane elevation and implant placement: a 1‐ to 6‐year follow‐up study
Authors: Cricchio Giovanni , Sennerby Lars , Lundgren Stefan 
Published: September 2011

AbstractObjectives: To investigate the long‐term clinical and radiographic results of the maxillary sinus membrane elevation technique where implants were inserted in a void space created by the elevation of the sinus membrane without adding any graft material.Materials and methods: A total of 84 patients were subjected to 96 membrane elevation procedures and simultaneous placement of 239 implants. Changes of intra‐sinus and marginal bone height in relation to the implants were measured in intraoral radiographs taken at insertion, after 6 months of healing, after 6 months of loading and then annually. Computerized tomography was performed pre‐surgically and 6 months post‐surgically. Resonance Frequency Analyses measurements were performed at the time of implants placement, at abutment connection and after 6 months of loading. The implant follow‐up period ranged from a minimum of one to a maximum of 6 years after implants loading.Results: All implants were stable after 6 months of healing. A total of three implants were lost during the follow‐up period giving a survival rate of 98.7%. Radiography demonstrated on average 5.3±2.1 mm of intra‐sinus new bone formation after 6 months of healing. RFA measurements showed adequate primary stability (implant stability quotient 67.4±6.1) and small changes over time.Conclusion: Maxillary sinus membrane elevation and simultaneous placement of implants without the use of bone grafts or bone substitutes result in predictable bone formation with a high implant survival rate of 98.7% during a follow‐up period of up to 6 years. The intra‐sinus bone formation remained stable in the long‐term follow‐up. It is suggested that the secluded compartment allowed for bone formation according to the principle of guided tissue regeneration. The high implant survival rate of 98.7% indicated that the implants sufficiently supported the fixed bridges throughout the study period. This technique reduces the risks for morbidity related to harvesting of bone grafts and eliminates the costs of grafting materials.To cite this article:
Cricchio G, Sennerby L, Lundgren S. Sinus bone formation and implant survival after sinus membrane elevation and implant placement: a 1‐ to 6‐year follow‐up study. Clin. Oral Impl. Res. 22, 2011; 1200–1212. doi: 10.1111/j.1600‐0501.2010.02096.x
Periodontal regeneration following implantation of cementum and periodontal ligament‐derived cells
Authors: Nuñez J. , Sanz‐Blasco S. , Vignoletti F. , Muñoz F. , Arzate H. , Villalobos C. , Nuñez L. , Caffesse R. G. , Sanz M. 
Published: September 2011

Nuñez J, Sanz‐Blasco S, Vignoletti F, Muñoz F, Arzate H, Villalobos C, Nuñez L, Caffesse RG, Sanz M. Periodontal regeneration following implantation of cementum and periodontal ligament‐derived cells. J Periodont Res 2012; 47: 33–44. © 2011 John Wiley & Sons A/SBackground and Objective:  The periodontal regeneration of bone defects is often unsatisfactory and could be largely improved by cell therapy. Therefore, the purpose of this study was to evaluate the regenerative potential of implanting canine cementum‐derived cells (CDCs) and canine periodontal ligament‐derived cells (PDLDCs) in experimentally created periodontal intrabony defects in beagle dogs.Material and Methods:  Cells were obtained from premolars extracted from four beagle dogs. Three‐wall intrabony periodontal defects, 3 mm wide and 4 mm deep, were surgically created in their second and fourth premolars and plaque was allowed to accumulate. Once the defects were surgically debrided, periodontal regeneration was attempted by random implantation of collagen sponges embedded with 750,000 CDCs, 750,000 PDLDCs or culture medium. After 3 mo of healing, specimens were obtained and periodontal regenerative outcomes were assessed histologically and histometrically.Results:  The histological analysis showed that a minimal amount of new cementum was formed in the control group (1.56 ± 0.39 mm), whereas in both test groups, significantly higher amounts of new cementum were formed (3.98 ± 0.59 mm in the CDC group and 4.07 ± 0.97 mm in the PDLDC group). The test groups also demonstrated a larger dimension of new connective tissue, resulting in a significantly more coronal level of histological attachment.Conclusion:  This proof‐of‐principle study suggests that cellular therapy, in combination with a collagen sponge, promoted periodontal regeneration in experimental intrabony periodontal defects.
Management of neutropenic enterocolitis in children with cancer
Authors: Sundell Nicklas , Boström Håkan , Edenholm Mats , Abrahamsson Jonas 
Published: September 2011

AbstractAim:  To describe the symptoms, clinical management and short‐term outcome in a series of paediatric oncology patients with severe typhlitis following conservative treatment.Methods:  Twelve episodes of severe typhlitis in 11 children with cancer treated at the paediatric oncology ward at Queen Silvias Children’s Hospital between 1995 and 2006 were analysed retrospectively. Data on symptoms, radiological findings, laboratory status and treatment as well as outcome were collected and analysed.Results:  In all episodes, the classical signs of neutropenia, fever, abdominal pain and thickening of the bowel wall were present. All were successfully treated with bowel rest, broadspectrum antibiotics and supportive care. After recovery from typhlitis, three patients needed surgical intervention because of complications.Conclusion:  A high clinical suspicion combined with radiological imaging aids early diagnosis. Predisposing factors for developing typhlitis were haematologic malignancy and treatment with chemotherapy within 3 weeks of onset. Supportive care, bowel rest including parenteral nutrition, correction of cytopenias and aggressive antimicrobial treatment is essential. Measurements of C‐reactive protein in blood may be of benefit when assessing the clinical course.
Infrared (810 nm) Low‐level Laser Therapy in Rat Achilles Tendinitis: A Consistent Alternative to Drugs
Authors: Marcos Rodrigo Labat , Leal Junior Ernesto Cesar Pinto , de Moura Messias Felipe , Catelli de Carvalho Maria Helena , Pallotta Rodney Capp , Frigo Lúcio , dos Santos Rosângela Aparecida , Ramos Luciano , Teixeira Simone , Bjordal Jan Magnus , Lopes‐Martins Rodrigo Álvaro Brandão 
Published: September 2011

AbstractNonsteroidal anti‐inflammatory drugs (NSAIDs) are widely used and can reduce musculoskeletal pain in spite of the cost of adverse reactions like gastrointestinal ulcers or cardiovascular events. The current study investigates if a safer treatment such as low‐level laser therapy (LLLT) could reduce tendinitis inflammation, and whether a possible pathway could be through inhibition of either of the two‐cyclooxygenase (COX) isoforms in inflammation. Wistar rats (six animals per group) were injected with saline (control) or collagenase in their Achilles tendons. Then, we treated them with three different doses of IR LLLT (810 nm; 100 mW; 10 s, 30 s and 60 s; 3.57 W cm−2; 1 J, 3 J, 6 J) at the sites of the injections, or intramuscular diclofenac, a nonselective COX inhibitor/NSAID. We found that LLLT dose of 3 J significantly reduced inflammation through less COX‐2‐derived gene expression and PGE2 production, and less edema formation compared to nonirradiated controls. Diclofenac controls exhibited significantly lower PGE2 cytokine levels at 6 h than collagenase control, but COX isoform 1‐derived gene expression and cytokine PGE2 levels were not affected by treatments. As LLLT seems to act on inflammation through a selective inhibition of the COX‐2 isoform in collagenase‐induced tendinitis, LLLT may have potential to become a new and safer nondrug alternative to coxibs.
DEVELOPING "POTENTIAL ENTREPRENEURS" IN HIGHER EDUCATION INSTITUTES
Authors: PETRIDOU EUGENIA , SARRI KATERINA 
Published: September 2011

Successful entrepreneurial activities are a function of human venture and environmental conditions, since the key to improving entrepreneurial perceptions and attitudes within society and within Higher Education (HE) institutions lies in education. The purpose of this paper is to address issues surrounding entrepreneurial education in HE in Greece, and describes the delivery and evaluation of two programs. The programs were offered by a public university and a public technological & educational institute designed to create opportunities for learning entrepreneurial capacities, in order to develop a framework for the design and implementation of such activities. Research results, concerning (i) the programs' concept and (ii) the degree that the programs influence the students' knowledge, skills and attitudes towards the undertaking of entrepreneurial activities, provide useful information for academicians, educators, educational managers and policy makers, concerning the design of similar programs. The methodology used brings in the description of each program's structure (in terms of its formation, development, implementation and evaluation) and the evaluation of its effectiveness, based on a pre- and post-analysis of students' perceptions from each institution. Data were collected from 904 students, with both business and scientific-technological studies background. The analysis of data provides useful conclusions in relation to (i) the design of entrepreneurial education, (i.e. emphasis should be placed on the networking with the business world, the laboratory assistance, the mentoring process, the participants' scientific background) and (ii) the accomplishment of the two programs' objectives in "developing potential entrepreneurs", which seems to be moderately positive.
Induced Adipocyte Cell-Sheet Ameliorates Cardiac Dysfunction in a Mouse Myocardial Infarction Model
Authors: Imanishi Yukiko , Miyagawa Shigeru , Maeda Norikazu , Fukushima Satsuki , Kitagawa-Sakakida Satoru , Daimon Takashi , Hirata Ayumu , Shimizu Tatsuya , Okano Teruo , Shimomura Iichiro , Sawa Yoshiki 
Published: September 2011

Background—
A drug delivery system that constitutively and effectively retains cardioprotective reagents in the targeted myocardium has long been sought to treat acute myocardial infarction. We hypothesized that a scaffold-free induced adipocyte cell-sheet (iACS), transplanted on the surface of the heart, might intramyocardially secrete multiple cardioprotective factors including adiponectin (APN), consequently attenuating functional deterioration after acute myocardial infarction.

Methods and Results—
Induced ACS were generated from adipose tissue–derived cells of wild-type (WT) mice (C57BL/6J), which secreted abundant APN, hepatocyte growth factor, and vascular endothelial growth factor in vitro. Transplanted iACS secreted APN into the myocardium of APN-knockout (KO) mice at 4 weeks. APN was also detected in the plasma of iACS-transplanted APN-KO mice at 3 months (245±113 pg/mL). After left anterior descending artery ligation, iACS, generated from either WT (n=40) or APN-KO (n=40) mice, were grafted onto the surface of the anterior left ventricular wall of WT mice, or only left anterior descending artery ligation was performed (n=43). Two days later, inflammation and infarct size were significantly diminished only in the WT-iACS treated mice. One month later, cardiomyocyte diameter and percent fibrosis were smaller, whereas ejection fraction and survival were greater in the WT-iACS treated mice compared with the KO-iACS–treated or nontreated mice.

Conclusions—
Cardioprotective factors including APN, hepatocyte growth factor, and vascular endothelial growth factor were secreted from iACS. Transplantation of iACS onto the acute myocardial infarction heart attenuated infarct size, inflammation, and left ventricular remodeling, mediated by intramyocardially secreted APN in a constitutive manner. This method might be a novel drug delivery system to treat heart disease.
Restrictive Mitral Annuloplasty With or Without Surgical Ventricular Restoration in Ischemic Dilated Cardiomyopathy With Severe Mitral Regurgitation
Authors: Shudo Yasuhiro , Taniguchi Kazuhiro , Takeda Koji , Sakaguchi Taichi , Funatsu Toshihiro , Matsue Hajime , Miyagawa Shigeru , Kondoh Haruhiko , Kainuma Satoshi , Kubo Koji , Hamada Seiki , Izutani Hironori , Sawa Yoshiki 
Published: September 2011

Background—
We assessed changes in left ventricular (LV) volume and function and in regional myocardial wall stress in noninfarcted segments after restrictive mitral annuloplasty (RMA) with or without surgical ventricular restoration (SVR).

Methods and Results—
Thirty-nine patients with ischemic cardiomyopathy (ejection fraction ≤0.35) and severe mitral regurgitation (≥3) were studied before and 2.8 months after surgery with cine-angiographic multidetector computed tomography (cine-MDCT). Eighteen underwent RMA alone (RMA group) and 21 underwent RMA and SVR (RMA+SVR group). In addition to measuring conventional parameters (LV end-diastolic volume index [LVEDVI], LV end-systolic volume index [LVESVI], and LV ejection fraction), we evaluated the regional circumferential end-systolic wall stress and mean circumferential fiber shortening in both the basal and mid-LV regions using 3-dimensional cine-MDCT images. LV end-diastolic and end-systolic volume indexes were significantly greater in the RMA+SVR group than in the RMA group preoperatively, but these values did not differ significantly postoperatively. LV end-diastolic and end-systolic volume indexes decreased significantly, by 21% and 27% after RMA and by 35% and 42% after RMA and SVR, and the percent reductions in LV end-diastolic and end-systolic volume indexes were significantly larger in the RMA+SVR group. Regional end-systolic wall stress decreased and circumferential fiber shortening increased significantly in the noninfarcted regions after RMA with or without SVR.

Conclusions—
RMA plus SVR showed a potentially greater reduction of LV end-diastolic and end-systolic volume indexes than RMA alone. In selected patients with more advanced LV remodeling, concomitant SVR may favorably affect the LV reverse-remodeling process induced by RMA.
Pravastatin Reduces Marfan Aortic Dilation
Authors: McLoughlin Darren , McGuinness Jonathan , Byrne John , Terzo Eloisa , Huuskonen Vilhelmiina , McAllister Hester , Black Alexander , Kearney Sinead , Kay Elaine , Hill Arnold D.K. , Dietz Harry C. , Redmond J. Mark 
Published: September 2011

Background—
The sequelae of aortic root dilation are the lethal consequences of Marfan syndrome. The root dilation is attributable to an imbalance between deposition of matrix elements and metalloproteinases in the aortic medial layer as a result of excessive transforming growth factor-beta signaling. This study examined the efficacy and mechanism of statins in attenuating aortic root dilation in Marfan syndrome and compared effects to the other main proposed preventative agent, losartan.

Methods and Results—

Marfan mice heterozygous for a mutant allele encoding a cysteine substitution in fibrillin-1 (C1039G) were treated daily from 6 weeks old with pravastatin 0.5g/L or losartan 0.6 g/L. The end points of aortic root diameter (n=25), aortic thickness, and architecture (n=10), elastin volume (n=5), dp/dtmax (maximal rate of change of pressure) (cardiac catheter; n=20), and ultrastructural analysis with stereology (electron microscopy; n=5) were examined. The aortic root diameters of untreated Marfan mice were significantly increased in comparison to normal mice (0.161±0.001 cm vs 0.252±0.004 cm;
P
<0.01). Pravastatin (0.22±0.003 cm;
P
<0.01) and losartan (0.221±0.004 cm;
P
<0.01) produced a significant reduction in aortic root dilation. Both drugs also preserved elastin volume within the medial layer (pravastatin 0.23±0.02 and losartan 0.29±0.03 vs untreated Marfan 0.19±0.02;
P
=0.01; normal mice 0.27±0.02). Ultrastructural analysis showed a reduction of rough endoplasmic reticulum in smooth muscle cells with pravastatin (0.022±0.004) and losartan (0.013±0.001) compared to untreated Marfan mice (0.035±0.004;
P
<0.01).

Conclusions—
Statins are similar to losartan in attenuating aortic root dilation in a mouse model of Marfan syndrome. They appear to act through reducing the excessive protein manufacture by vascular smooth muscle cells, which occurs in the Marfan aorta. As a drug that is relatively well-tolerated for long-term use, it may be useful clinically.
Novel MicroRNA Prosurvival Cocktail for Improving Engraftment and Function of Cardiac Progenitor Cell Transplantation
Authors: Hu Shijun , Huang Mei , Nguyen Patricia K. , Gong Yongquan , Li Zongjin , Jia Fangjun , Lan Feng , Liu Junwei , Nag Divya , Robbins Robert C. , Wu Joseph C. 
Published: September 2011

Background—
Although stem cell therapy has provided a promising treatment for myocardial infarction, the low survival of the transplanted cells in the infarcted myocardium is possibly a primary reason for failure of long-term improvement. Therefore, the development of novel prosurvival strategies to boost stem cell survival will be of significant benefit to this field.

Methods and Results—
Cardiac progenitor cells (CPCs) were isolated from transgenic mice, which constitutively express firefly luciferase and green fluorescent protein. The CPCs were transduced with individual lentivirus carrying the precursor of miR-21, miR-24, and miR-221, a cocktail of these 3 microRNA precursors, or green fluorescent protein as a control. After challenge in serum free medium, CPCs treated with the 3 microRNA cocktail showed significantly higher viability compared with untreated CPCs. After intramuscular and intramyocardial injections, in vivo bioluminescence imaging showed that microRNA cocktail-treated CPCs survived significantly longer after transplantation. After left anterior descending artery ligation, microRNA cocktail-treated CPCs boost the therapeutic efficacy in terms of functional recovery. Histological analysis confirmed increased myocardial wall thickness and CPC engraftment in the myocardium with the microRNA cocktail. Finally, we used bioinformatics analysis and experimental validation assays to show that Bim, a critical apoptotic activator, is an important target gene of the microRNA cocktail, which collectively can bind to the 3′UTR region of Bim and suppress its expression.

Conclusions—
We have demonstrated that a microRNA prosurvival cocktail (miR-21, miR-24, and miR-221) can improve the engraftment of transplanted cardiac progenitor cells and therapeutic efficacy for treatment of ischemic heart disease.
Distinguishing symbolic and evidence-based policies: the Brazilian efforts to increase the quality of basic education
Authors: de Vries Michiel S. 
Published: September 2011

This article addresses the question how to distinguish symbolic policies from evidence-based policies, using the efforts of the Brazilian government to improve the achievements of pupils in primary schools as an illustration. The Brazilian government aimed for achievements in basic education in its country equal to those in the developed world and implemented policies in line with decentralization of the schooling system and improvement of the training of teachers. It will be shown that such policies are symbolic in the sense that they may have an appeal to the national population and to the outside world, but are hardly effective. This article’s main argument is that governments can prevent such outcomes when they are less opportunistic in following international fashions, such as the striving for decentralization, and have policymakers analyze the problem somewhat more thoroughly, resulting in evidence-based policies. Points for practitioners This study points to four criteria to distinguish symbolic versus evidence-based policies and gives an example of how to use these criteria in practice. This is useful for policymakers, policy analysts and policy evaluators.
A radiological study to define safe zones for drilling during plating of clavicle fractures
Authors: Sinha A. , Edwin J. , Sreeharsha B. , Bhalaik V. , Brownson P. 
Published: September 2011

This study investigated the anatomical relationship between the clavicle and its adjacent vascular structures, in order to define safe zones, in terms of distance and direction, for drilling of the clavicle during osteosynthesis using a plate and screws following a fracture. We used reconstructed three-dimensional CT arteriograms of the head, neck and shoulder region. The results have enabled us to divide the clavicle into three zones based on the proximity and relationship of the vascular structures adjacent to it. The results show that at the medial end of the clavicle the subclavian vessels are situated behind it, with the vein intimately related to it. In some scans the vein was opposed to the posterior cortex of the clavicle. At the middle one-third of the clavicle the artery and vein are a mean of 17.02 mm (5.4 to 26.8) and 12.45 mm (5 to 26.1) from the clavicle, respectively, and at a mean angle of 50° (12 to 80) and 70° (38 to 100), respectively, to the horizontal. At the lateral end of the clavicle the artery and vein are at mean distances of 63.4 mm (46.8 to 96.5) and 75.67 mm (50 to 109), respectively. An appreciation of the information gathered from this study will help minimise the risk of inadvertent iatrogenic vascular injury during plating of the clavicle.
Treatment of painful osteoporotic vertebral compression fractures
Authors: Muijs S. P. J. , van Erkel A. R. , Dijkstra P. D. S. 
Published: September 2011

Vertebral compression fractures are the most prevalent complication of osteoporosis and percutaneous vertebroplasty (PVP) has emerged as a promising addition to the methods of treating the debilitating pain they may cause.Since PVP was first reported in the literature in 1987, more than 600 clinical papers have been published on the subject. Most report excellent improvements in pain relief and quality of life. However, these papers have been based mostly on uncontrolled cohort studies with a wide variety of inclusion and exclusion criteria. In 2009, two high-profile randomised controlled trials were published in the New England Journal of Medicine which led care providers throughout the world to question the value of PVP. After more than two decades a number of important questions about the mechanism and the effectiveness of this procedure remain unanswered.