bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association between Doppler assessment and secondary cesarean delivery for intrapartum fetal compromise in small-for-gestational-age fetuses
Authors: Scholz Anna S. , Rónay Vanessa , Wallwiener Markus , Fluhr Herbert , von Au Alexandra , Spratte Julia , Wallwiener Stephanie , Elsaesser Michael 
Published: May 2024

Abstract
Purpose
To elucidate the association between arterial and venous Doppler ultrasound parameters and the risk of secondary cesarean delivery for intrapartum fetal compromise (IFC) and neonatal acidosis in small-for-gestational-age (SGA) fetuses.

Methods
This single-center, prospective, blinded, cohort study included singleton pregnancies with an estimated fetal weight (EFW) < 10th centile above 36 gestational weeks. Upon study inclusion, all women underwent Doppler ultrasound, including umbilical artery (UA) pulsatility index (PI), middle cerebral artery (MCA) PI, fetal aortic isthmus (AoI) PI, umbilical vein blood flow (UVBF), and modified myocardial performance index (mod-MPI). Primary outcome was defined as secondary cesarean section due to IFC.

Results
In total, 87 SGA pregnancies were included, 16% of which required a cesarean section for IFC. Those fetuses revealed lower UVBF corrected for abdominal circumference (AC) (5.2 (4.5–6.3) vs 7.2 (5.5–8.3), p = 0.001). There was no difference when comparing AoI PI, UA PI, ACM PI, or mod-MPI. No association was found for neonatal acidosis. After multivariate logistic regression, UVBF/AC remained independently associated with cesarean section due to IFC (aOR 0.61 [0.37; 0.91], p = 0.03) and yielded an area under the curve (AUC) of 0.78 (95% CI, 0.67–0.89). A cut-off value set at the 50th centile of UVBF/AC reached a sensitivity of 86% and specificity of 58% for the occurrence of cesarean section due to IFC (OR 8.1; 95% CI, 1.7–37.8, p = 0.003).

Conclusion
Low levels of umbilical vein blood flow (UVBF/AC) were associated with an increased risk among SGA fetuses to be delivered by cesarean section for IFC.
Integration of targeted metabolome and transcript profiling of Pseudomonas syringae-triggered changes in defence-related phytochemicals in oat plants
Authors: Pretorius Chanel J. , Dubery Ian A. 
Published: May 2024

Abstract
Main conclusion
A gene-to-metabolite approach afforded new insights regarding defence mechanisms in oat plants that can be incorporated into plant breeding programmes for the selection of markers and genes related to disease resistance.

Abstract
Monitoring metabolite levels and changes therein can complement and corroborate transcriptome (mRNA) data on plant–pathogen interactions, thus revealing mechanisms involved in pathogen attack and host defence. A multi-omics approach thus adds new layers of information such as identifying metabolites with antimicrobial properties, elucidating metabolomic profiles of infected and non-infected plants, and reveals pathogenic requirements for infection and colonisation. In this study, two oat cultivars (Dunnart and SWK001) were inoculated with Pseudomonas syringae pathovars, pathogenic and non-pathogenic on oat. Following inoculation, metabolites were extracted with methanol from leaf tissues at 2, 4 and 6 days post-infection and analysed by multiple reaction monitoring (MRM) on a triple quadrupole mass spectrometer system. Relatedly, mRNA was isolated at the same time points, and the cDNA analysed by quantitative PCR (RT-qPCR) for expression levels of selected gene transcripts associated with avenanthramide (Avn) biosynthesis. The targeted amino acids, hydroxycinnamic acids and Avns were successfully quantified. Distinct cultivar-specific differences in the metabolite responses were observed in response to pathogenic and non-pathogenic strains. Trends in aromatic amino acids and hydroxycinnamic acids seem to indicate stronger activation and flux through these pathways in Dunnart as compared to SWK001. A positive correlation between hydroxycinnamoyl-CoA:hydroxyanthranilate N-hydroxycinnamoyl transferase (HHT) gene expression and the abundance of Avn A in both cultivars was documented. However, transcript profiling of selected genes involved in Avn synthesis did not reveal a clear pattern to distinguish between the tolerant and susceptible cultivars.

Graphical abstract
Ivermectin resistance mechanisms in ectoparasites: a scoping review
Authors: Furnival-Adams Joanna , Kiuru Caroline , Sagna André Barembaye , Mouline Karine , Maia Marta , Chaccour Carlos 
Published: May 2024

AbstractIvermectin mass drug administration has been used for decades to target human and veterinary ectoparasites, and is currently being considered for use against malaria vectors. Although there have been few reports of resistance to date in human ectoparasites, we must anticipate the development of resistance in mosquitoes in the future. Hence, through this review, we mapped the existing evidence on ivermectin resistance mechanisms in human ectoparasites. A search was conducted on the 8th November 2023 through databases, PubMed, Web of Science, and Google Scholar, using terms related to ivermectin, human and veterinary ectoparasites, and resistance. Abstracts (5893) were screened by JFA and CK. Data on the study organism, the type of resistance, the analysis methods, and, where applicable, the gene loci of interest were extracted from the studies. Details of the methodology and results of each study were summarised narratively and in a table. Eighteen studies were identified describing ivermectin resistance in ectoparasites. Two studies described target site resistance; and 16 studies reported metabolic resistance and/or changes in efflux pump expression. The studies investigated genetic mutations in resistant organisms, detoxification, and efflux pump expression in resistant versus susceptible organisms, and the effect of synergists on mortality or detoxification enzyme/efflux pump transcription. To date, very few studies have been conducted examining the mechanisms of ivermectin resistance in ectoparasites, with only two on Anopheles spp. Of the existing studies, most examined detoxification and efflux pump gene expression, and only two studies in lice investigated target-site resistance. Further research in this field should be encouraged, to allow for close monitoring in ivermectin MDA programmes, and the development of resistance mitigation strategies.
Graphical Abstract
Association between sodium–glucose cotransporter-2 (SGLT2) inhibitors and macular degeneration in patients with diabetes: a nationwide population-based study in Taiwan
Authors: Hsu Min-Yen , Luo Kai-Shin , Chou Chien-Chih , Lin Yu-Hsiang , Hung Yu-Chien , Chuang Wu-Lung , Tsai Stella Chin-Shaw , Lin Heng-Jun , Yu Teng-Shun , Tsai Fuu-Jen , Chang Kuang-Hsi 
Published: May 2024

Abstract
Aims
Evidence showed that SGLT2 inhibitors have greater protective effects against retinal diseases compared to other hypoglycemic agents. Thus, we explore the association between SGLT2 inhibitor usage and macular degeneration (MD) in Taiwanese patients with diabetes.

Methods
The National Health Insurance (NHI) program's claim data are released as the National Health Insurance Research Database (NHIRD). This database covers more than 99% of the residents in Taiwan. We included data on patients who were newly diagnosed with type 2 diabetes mellitus (ICD-9-CM: 250, exclude 250.1x; ICD-10-CM: E11), with an age at diagnosis of over 20 years as our study population. Patients who received (sodium-glucose cotransporter 2 inhibitor) SGLT2i (ATC code: A10BK) over 90 days in 2016–2019 were defined as the SGLT2i cohort. Conversely, patients who did never received SGLT2i were defined as the non-SGLT2i cohort. The exclusion criteria were having MD before the index date, receiving SGLT2i within 1–89 days, and missing data on sex, age, or days of SGLT2i usage. Two cohorts were matched by 1:1 propensity score matching, which was based on age, sex, payroll bracket grade, urbanization, comorbidities, and medications.

Results
Compared to non-SGLT2i cohort, patients who received SGLT2i had a significantly lower risk of MD (adjusted hazard ratio = 0.70, 95%CI = 0.66–0.75).

Conclusions
We found that SGLT2is has a strong protective effect against MD in patients with diabetes. SGLT2is may have benefits beyond glycemic control in patients with DR. However, additional clinical and experimental studies are required.
Tuning structure learning algorithms with out-of-sample and resampling strategies
Authors: Chobtham Kiattikun , Constantinou Anthony C. 
Published: May 2024

AbstractOne of the challenges practitioners face when applying structure learning algorithms to their data involves determining a set of hyperparameters; otherwise, a set of hyperparameter defaults is assumed. The optimal hyperparameter configuration often depends on multiple factors, including the size and density of the usually unknown underlying true graph, the sample size of the input data, and the structure learning algorithm. We propose a novel hyperparameter tuning method, called the Out-of-sample Tuning for Structure Learning (OTSL), that employs out-of-sample and resampling strategies to estimate the optimal hyperparameter configuration for structure learning, given the input dataset and structure learning algorithm. Synthetic experiments show that employing OTSL to tune the hyperparameters of hybrid and score-based structure learning algorithms leads to improvements in graphical accuracy compared to the state-of-the-art. We also illustrate the applicability of this approach to real datasets from different disciplines.
The methods for improving large-scale multi-view clustering efficiency: a survey
Authors: Yang Zengbiao , Tan Yihua 
Published: May 2024

AbstractThe diversity and large scale of multi-view data have brought more significant challenges to conventional clustering technology. Recently, multi-view clustering has received widespread attention because it can better use different views’ consensus and complementary information to improve clustering performance. Simultaneously, many researchers have proposed various algorithms to reduce the computational complexity to accommodate the demands of large-scale multi-view clustering. However, the current reviews do not summarize from the perspective of reducing the computational complexity of large-scale multi-view clustering. Therefore, this paper outlines various high-frequency methods used in recent years to reduce the computational complexity of large-scale multi-view clustering, i.e. third-order tensor t-SVD, anchors-based graph construction, matrix blocking, and matrix factorization, and compares the corresponding algorithms based on several open datasets. Finally, the strengths and weaknesses of the current algorithm and the point of improvement are analyzed.
Rutin attenuates ensartinib-induced hepatotoxicity by non-transcriptional regulation of TXNIP
Authors: Wu Wentong , Li Jinjin , Yin Yiming , Zhou Yourong , Huang Xiangliang , Cao Yashi , Chen Xueqin , Zhou Yunfang , Du Jiangxia , Xu Zhifei , Yang Bo , He Qiaojun , Yang Xiaochun , Hu Yuhuai , Yan Hao , Luo Peihua 
Published: May 2024

AbstractEnsartinib, an approved ALK inhibitor, is used as a first-line therapy for advanced ALK-positive non-small cell lung cancer in China. However, the hepatotoxicity of ensartinib seriously limits its clinical application and the regulatory mechanism is still elusive. Here, through transcriptome analysis we found that transcriptional activation of TXNIP was the main cause of ensartinib-induced liver dysfunction. A high TXNIP level and abnormal TXNIP translocation severely impaired hepatic function via mitochondrial dysfunction and hepatocyte apoptosis, and TXNIP deficiency attenuated hepatocyte apoptosis under ensartinib treatment. The increase in TXNIP induced by ensartinib is related to AKT inhibition and is mediated by MondoA. Through screening potential TXNIP inhibitors, we found that the natural polyphenolic flavonoid rutin, unlike most reported TXNIP inhibitors can inhibit TXNIP by binding to TXNIP and partially promoting its proteasomal degradation. Further studies showed rutin can attenuate the hepatotoxicity of ensartinib without antagonizing its antitumor effects. Accordingly, we suggest that TXNIP is the key cause of ensartinib-induced hepatotoxicity and rutin is a potential clinically safe and feasible therapeutic strategy for TXNIP intervention.
Graphical Abstract
Divider verification using symbolic computer algebra and delayed don’t care optimization: theory and practical implementation
Authors: Konrad Alexander , Scholl Christoph , Mahzoon Alireza , Große Daniel , Drechsler Rolf 
Published: May 2024

AbstractRecent methods based on Symbolic Computer Algebra (SCA) have shown great success in formal verification of multipliers and—more recently—of dividers as well. In this paper we enhance known approaches by the computation of satisfiability don’t cares for so-called Extended Atomic Blocks (EABs) and by Delayed Don’t Care Optimization (DDCO) for optimizing polynomials during backward rewriting. Using those novel methods we are able to extend the applicability of SCA-based methods to further divider architectures which could not be handled by previous approaches. We successfully apply the approach to the fully automatic formal verification of large dividers (with bit widths up to 512).
Standardisierter Datenmanagementplan für die Bildungsforschung (Stamp) – Ein projektbegleitendes Tool für das Forschungsdatenmanagement
Authors: Künstler-Sment Julia , Eckert Simon , Favella Gianpiero , Kerwer Martin , Jansen Malte 
Published: May 2024

ZusammenfassungDie empirische Bildungsforschung zieht ihre Erkenntnisse aus der Erhebung und Auswertung von Daten. Einheitliche Standards sind notwendig, um den steigenden Anforderungen an das Forschungsdatenmanagement im Kontext einer zunehmenden Kultur des Datenteilens zu begegnen. Das Verbundprojekt Domain-Data-Protokolle für die empirische Bildungsforschung (DDP-Bildung) entwickelte hierzu den Stamp (Standardisierter Datenmanagementplan für die Bildungsforschung). Der Stamp basiert auf dem „Domain Data Protocol“-Konzept von Science Europe und dient der Sicherung der Datenqualität und der Nachnutzbarkeit von Forschungsdaten. In die Entwicklung des Stamps flossen Expertisen aus der Forschungsdateninfrastruktur sowie von der Scientific Community der Bildungsforschung geäußerte Bedarfe ein. Ein zentraler Unterschied zu klassischen Datenmanagementplänen besteht darin, dass der Stamp Informationsquellen verknüpft und fachspezifische Vorgehensweisen in Form von Praxisbeispielen unter Beachtung rechtlicher Vorgaben illustriert. Hierbei begleitet der Stamp wissenschaftliche Projekte von der Planungsphase (inklusive Projektanträgen) über die Erhebung und bis zur Archivierung der Daten. Die vorliegende Arbeit beschreibt den Entwicklungsprozess des Stamps und stellt dessen Bestandteile vor.
Correlation between the thyroid computed tomography value and thyroid function in hyperthyroidism: a retrospective study
Authors: Iwanaga Haruna , Fujita Naotoshi , Abe Shinji , Naganawa Shinji , Kato Katsuhiko 
Published: May 2024

Abstract
Objective
Radioiodine (I-131) therapy for hyperthyroidism is a well-established and safe treatment option. This study aimed to investigate the relationship between the computed tomography (CT) value and the function and volume of the thyroid gland by identifying the factors that induce changes in the CT value of patients with hyperthyroidism.

Methods
This retrospective study evaluated 38 patients with Graves’ disease and 10 patients with Plummer disease. To obtain the mean CT value and volume of the thyroid gland, the entire thyroid gland was set as the region of interest. A test dose of 3.7 MBq I-131 was administered before initiating I-131 therapy, and the radioiodine uptake (RIU) rate was assessed after 3, 24, 96, and 168 h. An approximate curve was plotted based on the RIU values obtained, and the effective half-life (EHL) was calculated. The correlation between the mean CT value and the volume of the thyroid gland, 24-h RIU, EHL, and the free triiodothyronine (FT3), free thyroxine (FT4), thyroid-stimulating hormone (TSH), and TSH receptor antibody (TRAb) levels was evaluated.

Results
The CT value exhibited a significant positive correlation with EHL in patients with Graves’ disease (r = 0.62, p < 0.0001) as well as patients with Plummer disease (r = 0.74, p < 0.05). However, it did not display any correlation with the remaining parameters.

Conclusion
The CT value is significantly correlated with EHL, suggesting that it reflects thyroid function and is mainly related to the factors associated with iodine discharge.
Developing a Whole Child School Screening Instrument: Evaluating Perceived Usability as an Initial Step in Planning for Consequential Validity
Authors: Koslouski Jessica B. , Chafouleas Sandra M. , Briesch Amy , Caemmerer Jacqueline M. , Melo Brittany 
Published: May 2024

AbstractWe are developing the Equitable Screening to Support Youth (ESSY) Whole Child Screener to address concerns prevalent in existing school-based screenings that impede goals to advance educational equity using universal screeners. Traditional assessment development does not include end users in the early development phases, instead relying on a psychometric approach. In working to develop the ESSY Whole Child Screener, we are integrating a mixed methods approach with attention to consequential validity from the outset of measure development. This approach includes end users in measure development decisions. In this study, we interviewed a diverse sample of school staff (n = 7), administrators (n = 3), and family caregivers (n = 8) to solicit their perceptions of the usability of the initial draft of the ESSY Whole Child Screener. We identified three overarching themes: (1) paving the road for implementation of a whole child screener, (2) potential roadblocks to use, and (3) suggested paths forward to maximize positive intended consequences. Paving the road for implementation of a whole child screener includes subthemes related to alignment with existing initiatives, comprehensive yet efficient design, and potential positive consequences of assessing the whole child. Potential roadblocks to use includes subthemes of staff buy-in, family comfort with contextual screening items, teacher accuracy, and school capacity to provide indicated supports. Suggested paths forward to maximize positive intended consequences include clear and precise messaging to staff and families, optimizing instrumentation and data collection procedures, and strengthening connections to data interpretation and use. We discuss next steps in the design and testing of the initial measure as well as assessment development more broadly.
New accelerator designs: NIMMS
Authors: Vretenar Maurizio , Benedetto Elena 
Published: May 2024

Abstract
Purpose
This article summarises the presentation given at the “Hadrontherapy: status and perspectives” event.

Methods
Structure, methodology, and objectives of the Next Ion Medical Machine Study collaboration are introduced. Its four Work Packages are: small synchrotrons for particle therapy, curved superconducting magnets for synchrotrons and gantries, superconducting gantry design, and high-frequency ion linacs. Synchrotrons under study include a superconducting design for carbon ion therapy, and a normal-conducting design for ions up to helium. Superconducting magnet R&D is carried out in two European projects. Within the scope of these projects, five magnet demonstrators with different technologies are in different phases of design and production. Beam optics and mechanical design of a superconducting gantry for carbon ions is being developed. A high-frequency linac design has been completed, and tests are starting on a prototype high-frequency injector.

Results
The designs of two facilities based on NIMMS technological developments are presented. A carbon ion research and therapy facility was designed for the SEEIIST project, based on a conventional synchrotron with high beam intensity. A smaller facility aimed at cancer therapy and research with light ions, in particular helium beams has also been designed. Both facilities can produce FLASH-type beams.

Conclusions
The traditional design of carbon ion therapy facilities can be improved by adding new features as higher beam intensity and new beam extraction schemes. A cost-effective alternative to the traditional design is a compact facility for light ions, exploiting the potential for treatment with helium ions and allowing an experimental programme with different ion species.
Exploration–Exploitation Mechanisms in Recurrent Neural Networks and Human Learners in Restless Bandit Problems
Authors: Tuzsus D. , Brands A. , Pappas I. , Peters J. 
Published: May 2024

AbstractA key feature of animal and human decision-making is to balance the exploration of unknown options for information gain (directed exploration) versus selecting known options for immediate reward (exploitation), which is often examined using restless bandit tasks. Recurrent neural network models (RNNs) have recently gained traction in both human and systems neuroscience work on reinforcement learning, due to their ability to show meta-learning of task domains. Here we comprehensively compared the performance of a range of RNN architectures as well as human learners on restless four-armed bandit problems. The best-performing architecture (LSTM network with computation noise) exhibited human-level performance. Computational modeling of behavior first revealed that both human and RNN behavioral data contain signatures of higher-order perseveration, i.e., perseveration beyond the last trial, but this effect was more pronounced in RNNs. In contrast, human learners, but not RNNs, exhibited a positive effect of uncertainty on choice probability (directed exploration). RNN hidden unit dynamics revealed that exploratory choices were associated with a disruption of choice predictive signals during states of low state value, resembling a win-stay-loose-shift strategy, and resonating with previous single unit recording findings in monkey prefrontal cortex. Our results highlight both similarities and differences between exploration behavior as it emerges in meta-learning RNNs, and computational mechanisms identified in cognitive and systems neuroscience work.
Regional extinction(s) but continental persistence in European Acheulean culture
Authors: Key Alastair 
Published: May 2024

Abstract
Traces of early hominin cultural dynamics are revealed through the spatial and temporal character of the archaeological record. In the European Lower Palaeolithic, biface occurrences provide insights into episodes of cultural loss, persistence and convergence during the Acheulean, the longest known prehistoric cultural phenomenon. Here, the cohesiveness of Europe’s Acheulean record is statistically assessed under multiple spatial scenarios. Repeated cycles of cultural loss are identified in northern Europe, while southern Europe is demonstrated to have a continuous record of Acheulean presence. These data support longstanding hypotheses concerning an absence of Acheulean populations in northern Europe during glacial periods – a result that should increasingly be applied with caution. In southern Europe, Iberia displays the loss of Acheulean cultural information between c. 850 and 500 thousand years ago, with the Italian peninsula potentially acting as a source population for its later reintroduction. When investigated at a continental-level there are no clear episodes of cultural loss. Current evidence therefore suggests that once Acheulean cultural information was introduced to Europe, it never wholly left.