bluuebunny/crossref_metadata_2025_split huggingface dataset:
Development of a tilt control method for a narrow-track three-wheeled vehicle
Authors: Berote J , Darling J , Plummer A 
Published: August 2011

The space and weight savings provided by narrow tilting vehicles could make them a solution to the pollution and congestion problems seen in urban environments. The success of this new type of vehicle relies heavily on the control method used to balance the vehicle in corners. A tilting three-wheeled vehicle was developed at the University of Bath as part of an EU-funded project. The original direct tilt control method implemented on the prototype was shown to perform well in steady state, but rapid transients were shown to potentially lead to instability. A new type of controller was therefore required to reduce the load transfer across the rear axle during transient state manoeuvres. This paper presents a linearized model of the tilting vehicle system which is used to optimize a new tilt controller in the frequency domain. The controller, which uses combined steer and tilt control inputs, is shown to significantly reduce transient roll moments compared to the previous control method. This results in a much safer and more predictable handling characteristic.
J. Krishnamurti and the Practice of Management
Authors: Srinivasan T. S. 
Published: August 2011

J Krishnamurti is widely regarded as one of the leading thinkers of our time. He attracted world-wide attention in the 1920s when he declined to accept the global leadership of the theosophical movement conferred on him by the leading lights of that movement at the time. Since then, until his death in 1984, he expounded through lectures and books his rather unorthodox views on religion and spirituality. While his views are generally unconventional, his core message, as developed in the following sections, seems to have strong roots in individual and social psychology. And it might, for that reason, be of some relevance to the practice of management. As Peter Drucker points out management has become a crucial activity in modern society. And quality of management has emerged as a critical factor in the success of families, businesses, non-profit organisations, communities and nations. This paper attempts to explore the relevance of Krishnamurti's message to the practice of management. The paper is exploratory rather than prescriptive in nature and its purpose is mainly to stimulate a debate on the subject rather than to offer any firm conclusions.
Financing Industrial Infrastructure in India: A Conspective Review
Authors: Sarkar A.N. 
Published: August 2011

Development of infrastructure is fast becoming critical to attaining desired level of economic growth in different industrial sectors in the country to keep pace with the Government's ongoing economic reforms initiatives as well as meeting the challenges thrown open by globalisation, especially under WTO regime. This paper offers a conspective over-view of the emerging roles played by various financial institutions in creation and strengthening of infrastructure to support large, medium and small-scale industrial ventures in different industrial sectors to help build and reconstruct Indian economic base. The paper also highlights certain major policy initiatives for accelaration in the magnitude as well as pace of growth of micro enterprises as well as rural infrastructure to help improve and transform the rural economy. The scope of complementary support of the insurance sector, mutual funds and venture capital by international donor agencies in financing industrial infrastructure on a selective basis has also been discussed in the paper.
Impact of Weightless Capital on the Pattern of Economic Growth and Employment
Authors: Agrawal Raj 
Published: August 2011

The defining feature of current world economic growth is the increasing scope of weightless capital in the composition of total output. It is currently debated among economic pundits to prophesy that the weightless capital is dramatically altering the structure of the world economy by increasing the higher level of economic growth in the era of liberalization and globalisation. Furthermore, It is also argued, new technologies will alter the structure and composition of total output. This may lead to an inexorable rise in unemployment in the world. Although there is not sufficient long-term empirical evidence that unemployment, at the aggregate level at least, is caused by technological changes resulting due to the impact of weightless capital. Although in the short run, there may be increase in unemployment but this is purely because of structural adjustment. In India's case this may not be because of only increasing role of weightless capital but presence of certain other factors vis-a-vis lesser investment in agriculture etc. Even though globalized and weightless activities have become increasingly important, they do not pose insurmountable threats to the world economy. The overall message may be an optimistic one: inequality and unemployment need not rise in the face of competition from the developing world in response to technological change. However, government policy can play a major role in promoting adjustment to change.
Building Corporate Transformation New HR Agenda
Authors: Bhandarker Asha 
Published: August 2011

The present study focuses on understanding the role of HR in achieving corporate transformation in the Indian context. Responses from 89 senior and top level HR professionals (questionnaire mode) brought out the following: HR professionals are experiencing a gap between organizational demand versus their own knowledge as well as personal competencies. HR role is changing, internal demands on HR professionals are increasing. The extent to which HR will be able to deliver and become a true strategic partner for change management will depend on the extent to which there is CEO support for HR, combined with HR professionals with high levels of expertise. Changes in HR practices are taking place, although not to the desired extent. CEO support and high HR status have been found to be essential to introduce systematic efforts to change mindsets in the company HR status has been found to be a key factor to facilitate change in mindsets, change in HR practices as well as in creating a pro-change orientation in the company.
Protection of intellectual Property Rights for Meeting WTO-Compatibility in Agriculture and Industrial Products
Authors: Sarkar A N 
Published: August 2011

Intellectual Property Rights (IPR) has assumed a great significance in the International Business Scene, especially in the context of WTO. Rapid growth in Science and Technology, enhanced diffusion of knowledge, IT innovations, e-Commerce, liberalization of trades etc. in post-reforms era has given a true International character to IPR. Various International conventions, legal agreements/Instruments (TRIPS) etc. have come into existence to give a fillip to the ongoing process with a view to protect the intellectual rights and interests of investors, consumers and civil societies at large. This paper discusses at some length the emerging trends in the growth of agri-business and SME Sector; their perspective and identification of areas of potential growth with which IPR related issues are implicated under WTO regime, with special reference to TRIPS. The status of compliance of TRIPS in India as well as future strategies to implement and comply with IPR provisions and related issues have been highlighted.
Reflections on Spiritual Foundations of Human Values for Global Business Management
Authors: Saraswat Satya Prakash 
Published: August 2011

Recent financial scandals at large multinational corporations such as Enron and WorldCom have brought into focus the need for “ethical” management in multinational corporations. For a deeper understanding of the issues, the spiritual foundation of ethics also need to be included in the academic dialogue and professional practice. In the Western countries, the discussion of spirituality in management is often limited to the Judeo-Christian tradition. With India and China becoming important players in the global economy, their spiritual traditions need to be included in the discourse to make it more comprehensive and relevant. This paper identifies fourteen principles of ethics from the Bhagavad-Gita and argues that it can be assimilated in the management practices of global corporations from a non-sectarian perspective. It identifies the sources of Hindu spirituality relevant to global business management, adumbrates the architecture of spirituality for business ethics, and provides an intellectual justification for a discussion of Hindu spirituality in relation to management.
Communication Effectiveness: A Case of Narayana Murthy's Resignation from Chairmanship of Bangalore International Airport Limited
Authors: Prasad T. 
Published: August 2011

In the month of October 2005, Narayana Murthy, the Chairman of Infosys Technologies Limited resigned from the Chairmanship of Bangalore International Airport Limited (BIAL). The issue came into focus as the former Prime Minister Devegowda made comments referring to Mr. Murthy's contribution as inadequate for the development of BIAL. As an aftermath, the Finance minister and the state Chief Minister are said to have persuaded Murthy to withdraw the resignation. But Murthy did not change his mind and resigned. Many people were surprised at Gowda's allegations on Murthy who is known for his Values, Principles and Success in business. Omkar Goswami, noted economist posed an open question—Who will history judge as a more capable leader of the people: Narayana Murthy or Devegowda? (Business World, Nov., 2005 pp. 26). It is unfortunate that a controversy like this involved two such significant individuals. At one level the spat between Murthy and Gowda may be viewed as a personal encounter but considering their status in society, the case has enormous learning potential for one and all. The case, analyzed properly can help us to understand many important issues like leadership in general, role of business leaders in social development projects and communication effectiveness. The present article is focused on the latter- communication effectiveness. The purpose of the present article is to analyze the effectiveness of Murthy's communication. For this, we analyze the contents of the resignation letter that Murthy had sent to the Chief Minister Dharam Singh. The reason for this is that the resignation letter contained Murthy's mindset and his feelings related to the conflict. Further, the resignation letter is one single most important communication that can make a significant impact on the whole episode. While analyzing the effectiveness of Murthy's communication, no attempt is made to incorporate Devegowda's communication related to the present case. Considering the involvement of a successful business leader like Murthy, the present case is a relatively rare incident in professional management circles. Hence, the present case is considered worth analyzing exclusively from the point of view of Murthy. A copy of Murthy's letter to Chief Minister Dharam Singh is provided below.
Do the Governance, Strategic and Organisational Practices Differ in Indian Family and Professionally Managed Firms?
Authors: Akbar M. 
Published: August 2011

The professional firms suffer from exogenous problems whereas the private family firms suffer from endogenous problems. This latter category is more common in the family firms of emerging markets. Based on a sample of 157 firms we examine the key characteristic differences in the managerial practices of family firms and professional firms and relate them to the possible agency problems. We present the typology of the firms based on ownership and control and further divide the issues into strategy, organisation and governance issues. The family firms themselves definitionally vary depending upon the ownership and control-based classification. We classify all firms into four categories, but we compare only professional firms on one hand and all hues of family firms as one block on the other owning to a relatively smaller sample size and lack of clear distinctions made by the respondents. However, the conclusions distinguish only on a few dimensions. But owing to institutional and economic context both family and professional firms look alike in more respects than they look different. This highlights the major impact of institutional influence on the behaviours of the firms. The analysis indicates that family firms suffer from the size, age and transparency disadvantages as compared to professional firms, but the strategic, organisational and governance practices do not differ very widely from each other.
Selecting an Advertising Agency: A Multi-Criteria Decision Making Approach
Authors: Faisal Mohd. Nishat , Khan Bilal Mustafa 
Published: August 2011

Indian economy is evolving day by day, and with an upswing spending power of its inhabitants advertising has been emerging as one of the most effective tools for the companies to reach out to their customers. Best advertisement agencies create value through giving the product personality, developing an understanding of product/service, creating an image or memorable picture of that product and above all trying to distinguish the product apart from its competitors. Today, advertising budgets of companies are rising and thus there are numerous agencies in the market vying for their shares. But there exists no method, which can take into account numerous criterions and their impact simultaneously under consideration while selecting a best advertisement agency. Selecting an advertisement agency is a multiple criteria decision-making (MCDM) problem that requires considering large number of complex factors as multiple evaluation criteria. A robust MCDM method should consider the interactions among criteria. Analytic network process (ANP) is a relatively new MCDM method which can deal with all kinds of interactions systematically. This paper proposes an ANP based methodology for the selection of advertisement agencies. ANP is capable of measuring the relative importance that captures all indirect interactions in a network required to be considered in an advertisement agency selection and also their interactions. Additionally, the proposed model is evaluated for a case company.
Predicting Patient Loyalty and Service Quality Relationship: A Case Study of Civil Hospital, Ahmedabad, India
Authors: Chahal Hardeep 
Published: August 2011

Purpose: In an era of heightened competition to sustain patient loyalty, quality of interpersonal experiences with the staff, operational quality of hospital operations and overall satisfaction and quality of the healthcare services, in general are to be understood in-depth in both public as well as private organisations. The concept of service quality has led to the growing research on various concepts such as total quality management, market orientation, learning orientation, strategic orientation along with invigorating focus on the customer loyalty and relationship management. The outcomes of service quality (customer relationship management and loyalty), end means for the organisational success, are most significant performance measurement tools in the present competitive market. The present study is an effort in this regard to identify the factors in sustaining customer longevity. Till today few studies in the developing settings were conducted to understand the types of relationship that exists between patient-loyalty and service quality. This study analyses the suitability of customer loyalty concept in the government hospitals through using a case study of one of the biggest hospitals operating in India. Methodology and Tools Applied: The research work is the case study of Civil Hospital Ahmedabad. The data is collected from 205 indoor patients of four departments namely general medicine, orthopedic, pediatrics, obstetric and gynecology. Inter and intra relationship among the measures of service quality and patient loyalty were analysed by using relevant statistical tools to draw out inferences. Findings: Among the three patient loyalty components, using provider again for the same services is found to be more significant followed by using provider again for different services and recommending providers to others in relation to overall service quality as dependent variable, and beta values are figured out as 0.15, 0.12 and 0.09 respectively The 35% R Square value for the model service quality – patient loyalty model indicate weak predictive power of this model. However at the same juncture the study found that no significant difference in the patients' perceptions with respect to patient loyalty and quality and per se, may be concluded that both are identical measures. Alternatively the more satisfied the patients are with the quality of their interactions with staff, the more likely they are going to take treatments for similar and different medical problems and would recommend the provider to their relatives and friends.
Design and development of TT30, a novel C3d-targeted C3/C5 convertase inhibitor for treatment of human complement alternative pathway–mediated diseases
Authors: Fridkis-Hareli Masha , Storek Michael , Mazsaroff Istvan , Risitano Antonio M. , Lundberg Ante S. , Horvath Christopher J. , Holers V. Michael 
Published: August 2011

AbstractTo selectively modulate human complement alternative pathway (CAP) activity implicated in a wide range of acute and chronic inflammatory conditions and to provide local cell surface and tissue-based inhibition of complement-induced damage, we developed TT30, a novel therapeutic fusion protein linking the human complement receptor type 2 (CR2/CD21) C3 fragment (C3frag = iC3b, C3dg, C3d)-binding domain with the CAP inhibitory domain of human factor H (fH). TT30 efficiently blocks ex vivo CAP-dependent C3frag accumulation on activated surfaces, membrane attack complex (MAC) formation and hemolysis of RBCs in a CR2-dependent manner, and with a ∼ 150-fold potency gain over fH, without interference of C3 activation or MAC formation through the classic and lectin pathways. TT30 protects RBCs from hemolysis and remains bound and detectable for at least 24 hours. TT30 selectively inhibits CAP in cynomolgus monkeys and is bioavailable after subcutaneous injection. Using a unique combination of targeting and effector domains, TT30 controls cell surface CAP activation and has substantial potential utility for the treatment of human CAP-mediated diseases.
Determination of the melon chloroplast and mitochondrial genome sequences reveals that the largest reported mitochondrial genome in plants contains a significant amount of DNA having a nuclear origin
Authors: Rodríguez-Moreno Luis , González Víctor M , Benjak Andrej , Martí M Carmen , Puigdomènech Pere , Aranda Miguel A , Garcia-Mas Jordi 
Published: August 2011

Abstract

Background
The melon belongs to the Cucurbitaceae family, whose economic importance among vegetable crops is second only to Solanaceae. The melon has a small genome size (454 Mb), which makes it suitable for molecular and genetic studies. Despite similar nuclear and chloroplast genome sizes, cucurbits show great variation when their mitochondrial genomes are compared. The melon possesses the largest plant mitochondrial genome, as much as eight times larger than that of other cucurbits.

Results
The nucleotide sequences of the melon chloroplast and mitochondrial genomes were determined. The chloroplast genome (156,017 bp) included 132 genes, with 98 single-copy genes dispersed between the small (SSC) and large (LSC) single-copy regions and 17 duplicated genes in the inverted repeat regions (IRa and IRb). A comparison of the cucumber and melon chloroplast genomes showed differences in only approximately 5% of nucleotides, mainly due to short indels and SNPs. Additionally, 2.74 Mb of mitochondrial sequence, accounting for 95% of the estimated mitochondrial genome size, were assembled into five scaffolds and four additional unscaffolded contigs. An 84% of the mitochondrial genome is contained in a single scaffold. The gene-coding region accounted for 1.7% (45,926 bp) of the total sequence, including 51 protein-coding genes, 4 conserved ORFs, 3 rRNA genes and 24 tRNA genes. Despite the differences observed in the mitochondrial genome sizes of cucurbit species, Citrullus lanatus (379 kb), Cucurbita pepo (983 kb) and Cucumis melo (2,740 kb) share 120 kb of sequence, including the predicted protein-coding regions. Nevertheless, melon contained a high number of repetitive sequences and a high content of DNA of nuclear origin, which represented 42% and 47% of the total sequence, respectively.

Conclusions
Whereas the size and gene organisation of chloroplast genomes are similar among the cucurbit species, mitochondrial genomes show a wide variety of sizes, with a non-conserved structure both in gene number and organisation, as well as in the features of the noncoding DNA. The transfer of nuclear DNA to the melon mitochondrial genome and the high proportion of repetitive DNA appear to explain the size of the largest mitochondrial genome reported so far.
Multidrug-resistance proteins are weak tumor associated antigens for colorectal carcinoma
Authors: Mullins Christina S , Eisold Sven , Klar Ernst , Linnebacher Michael 
Published: August 2011

Abstract

Background
Multidrug resistance (MDR) is a clinically, highly relevant phenomenon. Under chemotherapy many tumors show an increasing resistance towards the applied substance(s) and to a certain extent also towards other agents. An important molecular cause of this phenomenon is an increased expression of transporter proteins. The functional relationship between high expression levels and chemotherapy resistance makes these MDR and MRP (MDR related protein) proteins to interesting therapeutic targets. We here wanted to systematically analyze, whether these proteins are tumor specific antigens which could be targeted immunologically.

Results
Using the reverse immunology approach, 30 HLA-A2.1 restricted MDR and MRP derived peptides (MDP) were selected. Stimulated T cell lines grew well and mainly contained activated CD8+ cells. Peptide specificity and HLA-A2.1 restriction were proven in IFN-γ-ELISpot analyses and in cytotoxicity tests against MDP loaded target cells for a total of twelve peptides derived from MDR-1, MDR-3, MRP-1, MRP-2, MRP-3 and MRP-5. Of note, two of these epitopes are shared between MDR-1 and MDR-3 as well as MRP-2 and MRP-3. However, comparably weak cytotoxic activities were additionally observed against HLA-A2.1+ tumor cells even after upregulation of MDR protein expression by in vitro chemotherapy.

Conclusions
Taken together, these data demonstrate that human T cells can be sensitised towards MDPs and hence, there is no absolute immunological tolerance. However, our data also hint towards rather low endogenous tumor cell processing and presentation of MDPs in the context of HLA-A2.1 molecules. Consequently, we conclude that MDR and MRP proteins must be considered as weak tumor specific antigens-at least for colorectal carcinoma. Their direct contribution to therapy-failure implies however, that it is worth to further pursue this approach.