bluuebunny/crossref_metadata_2025_split huggingface dataset:
Removal efficiency of restroom ventilation revisited for short-term evaluation
Authors: Chen Yuyao , Zhai Zhiqiang , Yuan Zhe , He Guoqing 
Published: June 2024

AbstractVentilation efficiency or contaminant removal efficiency is often evaluated using the ratio between the concentrations in the exhaust air and the room air. This ratio does not truly represent the expectation of ventilation in restrooms, where dynamic airflow fields and sources are more typical. This study focuses on a short-term (10 min) pollutant removal percentage in a residential restroom featuring a dynamic airflow field, particularly with the onset of window-induced stack ventilation during toilet uses. Thirteen ventilation scenarios of a residential restroom were studied using the numerical method that was validated by a mock-up experiment. The scenarios differed in the operation of the exhaust fan and window. Results show that the 10-min pollutant removal percentage of a typical exhaust ventilation system at 10 h-1 air change rate (ACH) is only 68.5%. Under exhaust ventilation, opening the window can introduce both adverse short circuit and favorable stack ventilation depending on the difference between the indoor and outdoor temperatures. As the temperature difference increases from 0 to 12.5 °C, the removal percentage increases from below 50%, a drop due to short circuit, to above 98% thanks to a tripled ventilation rate. The human thermal plume has notable effect on the removal percentage, but its effect can be neglected with the presence of stack ventilation. The hybrid ventilation strategy has impact on perceived air quality and thermal comfort. When the outdoor air is colder, opening the window under exhaust ventilation may increase the current sitting user’s exposure to the self-produced pollutants but can reduce the exposure of the next immediate standing user. In addition, opening the window in cold days will make the toilet user thermally uncomfortable with reduced local temperatures and increased airflow velocities. The study highlights the importance of using the short-term removal percentage to evaluate the performance of restroom ventilation.
Global Warming Potentials of CO2 Uptake, CH4 Emissions, and Albedo Changes in a Restored Mangrove Ecosystem
Authors: Xu Zhe , Li Xianglan , Tian Pengpeng , Huang Yuting , Zhu Qingsong , Zou Huimin , Huang Ying , Zhang Zhao , Zhang Shumin , Chen Mengna , Chen Yahui 
Published: June 2024

AbstractRestoration of mangrove forests has garnered increasing global prominence as a nature‐based solution for carbon (C) sequestration. However, it was unclear whether the radiation forcing induced by methane (CH4) emissions and albedo changes during mangrove restoration processes can offset the cooling effect resulting from the net carbon dioxide (CO2) uptake. In this study, we measured the CO2, CH4, and albedo during 2020–2022 using an open‐path eddy covariance system in an 8‐year restored mangrove ecosystem afforested in Zhejiang Province, China. Their integrated global warming potentials (GWPs) were calculated to assess the climatic impact of mangrove restoration. The results showed that the restored mangroves functioned as a CO2 sink and a CH4 source, with annual values of −656.75 to −465.41 and 5.54 to 9.07 g C m−2 yr−1, respectively. The albedo varied slightly with a range of 0.11–0.13. The integrated GWPs of CO2, CH4, and albedo were −1,354.00 and −1,875.70 g CO2‐eq m−2 yr−1 over the 20‐ and 100‐year time horizons, respectively. The negative values indicated that the mangrove restoration had a net cooling effect, mainly due to CO2 uptake. The warming effects caused by CH4 emissions and albedo changes had the potential to partially offset CO2 uptake by 12.55%–36.51% and 0.08%–0.42%, respectively. Random forest analysis showed that photosynthetically active radiation (PAR) was the dominant driver on integrated GWPs with feature importance values of 0.34. Our results revealed that the cooling benefit of 8‐year restored mangroves remained significant, even when it was partially offset by CH4 emissions and albedo changes.
Demonstrating a Hybrid Machine Learning Approach for Snow Characteristic Estimation Throughout the Western United States
Authors: Steele Hannah , Small Eric E. , Raleigh Mark S. 
Published: June 2024

AbstractSnow is a critical component of global climate and provides water resources to over 1 billion people worldwide. Yet current measurement methods and modeling techniques lack the ability to fully capture snow characteristics such as snow water equivalent (SWE) and density across variable landscapes. In recent years, physics‐informed machine learning (ML) methods have demonstrated promise for combining data‐driven learning and physical information. However, this capability has not been widely explored within snow hydrology. Here, we develop a “hybrid” model that applies ML informed by outputs from a physical model and assess whether it provides more accurate estimations of SWE and snow density. We trained and evaluated models at 49 SNOw TELemetry locations spanning a range of snow climates in the western US using 9 years of daily data. The research addressed two questions. In the first, the performance of the hybrid model was compared against a plain neural network (long short‐term memory, Long‐Short Term Memory), a high‐quality physical model, and a statistical snow density model. The second question focused on how regionally trained hybrid models compared to a westwide model as well as their transferability between multiple snow regions. The results showed that combining physical information and ML reduced SWE Root Mean Square Error by 35% compared to a physical model and 51% compared to a neural network. Additionally, regional training only provided minimal benefits compared with a westwide model. These findings indicate that a hybrid approach can yield more accurate snowpack characterization than either physical snow models or ML alone.
Hydrological Research Evolution: A Large Language Model‐Based Analysis of 310,000 Studies Published Globally Between 1980 and 2023
Authors: Miao Chiyuan , Hu Jinlong , Moradkhani Hamid , Destouni Georgia 
Published: June 2024

AbstractHydrology plays a crucial role in understanding Earth's intricate water system and addressing water‐related problems, including against the backdrop of ongoing climate change. A retrospective review of the evolution of hydrology up to the current state of research is of great importance for understanding this role. While there have been some quantitative reviews of large numbers of hydrological publications, there still remains a lack of overarching hydrological research assessment, particularly with the focus on hydrological basins as fundamental spatial‐geographic units of hydrological analysis. Large language models, represented by OpenAI's ChatGPT, have demonstrated powerful textual understanding capabilities, making it possible to extract such overarching and basin information from hydrological publications. Here, we considered publications related to hydrology from Web of Science spanning January 1980 to October 2023, and parsed the information from this extensive body of literature by integrating a large language model and geocoding. These techniques enable quantitative analysis of research characteristics across different spatio‐temporal scales, focusing on hotspot topics, collaboration networks, and various basins worldwide. Our study revealed an increase in hydrological research since the 1990 s, with shifts in research priorities from groundwater and nutrients to climate change and ecohydrology. Some basins in North America and Europe have consistently been hotspots for hydrological research. Since the 2010s, there has been a noteworthy increase in interest toward basins in China and South Asia, but attention to many regions with frequent extreme rainfall remains insufficient. Geographical patterns show different preferred research topics for different basins, but climate change has emerged as the most prominent topic across all regions in the last decade. In conclusion, our study provides an effective approach to quantitative analysis of research trends, offering a fresh view on the evolution of hydrology as a research field, its focus on various hydrological basins around the world, and the emergence of overarching and basin‐specific hot topics over time.
Fifteen-year changes in health-related quality of life after bariatric surgery and non-surgical obesity treatment
Authors: Konttinen Hanna , Sjöholm Kajsa , Carlsson Lena M. S. , Peltonen Markku , Svensson Per-Arne 
Published: June 2024

Abstract
Background
Evidence on the long-term (≥10 years) development of health-related quality of life (HRQoL) following bariatric surgery is still limited and mainly based on small-scale studies. This study aimed to investigate (1) 15-year changes in mental, physical, social, and obesity-related HRQoL after bariatric surgery and non-surgical obesity treatment; and (2) whether sociodemographic factors and pre-operative health status are associated with 15-year HRQoL changes in the surgery group.

Methods
Participants were from the non-randomized, prospective, controlled Swedish Obese Subjects study. The surgery group (N = 2007, per-protocol) underwent gastric bypass, banding or vertical banded gastroplasty, and matched controls (N = 2040) received usual obesity care. Recruitment took place in 1987–2001 and measurements (including six HRQoL scales) were administered before treatment and after 0.5, 1, 2, 3, 4, 6, 8, 10 and 15 years. Multilevel mixed-effect regression models using all observations for estimation were conducted.

Results
Surgical patients experienced greater 15-year improvements in perceived health and overall mood, and greater reductions in depression, obesity-related problems, and social interaction limitations than controls (all p < 0.001, adjusted for baseline differences). Effect size (ES) was classified as large only for obesity-related problems (ES = 0.82). At the 15-year follow-up, surgical patients reported better perceived health (p < 0.001) and less obesity-related problems (p = 0.020) than controls. In the surgery group, patients with baseline diabetes had smaller 15-year reductions in social interaction limitations (p < 0.001) and depression (p = 0.049) compared to those without baseline diabetes. Although surgical patients with a history of psychiatric disorder reported lower HRQoL than those without such history over the 15-year follow-up, there were no significant differences in the long-term improvements between the two groups (p = 0.211–0.902).

Conclusions
Over 15 years, surgical patients experienced more positive development of HRQoL compared to those receiving usual care. This difference was large for obesity-related problems, but otherwise the differences were small. Patients with pre-operative diabetes might be at increased risk for smaller long-term HRQoL improvements.
Exosomal miR-17-5p derived from epithelial cells is involved in aberrant epithelium-fibroblast crosstalk and induces the development of oral submucosal fibrosis
Authors: Xie Changqing , Zhong Liang , Feng Hui , Wang Rifu , Shi Yuxin , Lv Yonglin , Hu Yanjia , Li Jing , Xiao Desheng , Liu Shuang , Chen Qianming , Tao Yongguang 
Published: June 2024

AbstractOral submucous fibrosis (OSF) is a chronic and inflammatory mucosal disease caused by betel quid chewing, which belongs to oral potentially malignant disorders. Abnormal fibroblast differentiation leading to disordered collagen metabolism is the core process underlying OSF development. The epithelium, which is the first line of defense against the external environment, can convert external signals into pathological signals and participate in the remodeling of the fibrotic microenvironment. However, the specific mechanisms by which the epithelium drives fibroblast differentiation remain unclear. In this study, we found that Arecoline-exposed epithelium communicated with the fibrotic microenvironment by secreting exosomes. MiR-17-5p was encapsulated in epithelial cell-derived exosomes and absorbed by fibroblasts, where it promoted cell secretion, contraction, migration and fibrogenic marker (α-SMA and collagen type I) expression. The underlying molecular mechanism involved miR-17-5p targeting Smad7 and suppressing the degradation of TGF-β receptor 1 (TGFBR1) through the E3 ubiquitination ligase WWP1, thus facilitating downstream TGF-β pathway signaling. Treatment of fibroblasts with an inhibitor of miR-17-5p reversed the contraction and migration phenotypes induced by epithelial-derived exosomes. Exosomal miR-17-5p was confirmed to function as a key regulator of the phenotypic transformation of fibroblasts. In conclusion, we demonstrated that Arecoline triggers aberrant epithelium-fibroblast crosstalk and identified that epithelial cell-derived miR-17-5p mediates fibroblast differentiation through the classical TGF-β fibrotic pathway, which provided a new perspective and strategy for the diagnosis and treatment of OSF.
Consensus definition and diagnostic criteria for neonatal encephalopathy—study protocol for a real-time modified delphi study
Authors: Branagan Aoife , Hurley Tim , Quirke Fiona , Devane Declan , Taneri Petek E. , Badawi Nadia , Sinha Bharati , Bearer Cynthia , Bloomfield Frank H. , Bonifacio Sonia L. , Boylan Geraldine , Campbell Suzann K. , Chalak Lina , D’Alton Mary , deVries Linda S. , El Dib Mohamed , Ferriero Donna M. , Gale Chris , Gressens Pierre , Gunn Alistair J. , Kay Sarah , Maeso Beccy , Mulkey Sarah B. , Murray Deirdre M. , Nelson Karin B. , Nesterenko Tetyana H. , Pilon Betsy , Robertson Nicola J. , Walker Karen , Wusthoff Courtney J. , Molloy Eleanor J. ,   Steering Group for DEFiNE (Definition of Neonatal Encephalopathy)
Published: June 2024

Abstract

Background
‘Neonatal encephalopathy’ (NE) describes a group of conditions in term infants presenting in the earliest days after birth with disturbed neurological function of cerebral origin. NE is aetiologically heterogenous; one cause is peripartum hypoxic ischaemia. Lack of uniformity in the terminology used to describe NE and its diagnostic criteria creates difficulty in the design and interpretation of research and complicates communication with families. The DEFINE study aims to use a modified Delphi approach to form a consensus definition for NE, and diagnostic criteria.

Methods
Directed by an international steering group, we will conduct a systematic review of the literature to assess the terminology used in trials of NE, and with their guidance perform an online Real-time Delphi survey to develop a consensus diagnosis and criteria for NE. A consensus meeting will be held to agree on the final terminology and criteria, and the outcome disseminated widely.

Discussion
A clear and consistent consensus-based definition of NE and criteria for its diagnosis, achieved by use of a modified Delphi technique, will enable more comparability of research results and improved communication among professionals and with families.

Impact

The terms Neonatal Encephalopathy and Hypoxic Ischaemic Encephalopathy tend to be used interchangeably in the literature to describe a term newborn with signs of encephalopathy at birth. This creates difficulty in communication with families and carers, and between medical professionals and researchers, as well as creating difficulty with performance of research.

The DEFINE project will use a Real-time Delphi approach to create a consensus definition for the term ‘Neonatal Encephalopathy’.

A definition formed by this consensus approach will be accepted and utilised by the neonatal community to improve research, outcomes, and parental experience.
Bronchiolitis: evidence-based management in high-risk infants in the intensive care setting
Authors: Walsh Ruth , Costello Liam , DiCosimo Alexandria , Doyle Anne-Marie , Kehoe Laura , Mulhall Cormac , O’Hara Sean , Elnazir Basil , Meehan Judith , Isweisi Eman , Semova Gergana , Branagan Aoife , Roche Edna , Molloy Eleanor 
Published: June 2024

Abstract

Aim
Systematically review the management of infants with severe bronchiolitis in a paediatric intensive care unit (PICU) setting with a focus on high-risk infants to identify gaps in evidence-based knowledge.

Methods
This systematic review utilised Preferred Reporting Items for Systematic Review and Meta-analysis Protocols (PRISMA-P) to examine the literature on the PICU management of bronchiolitis in infants <24 months old. Three databases, Embase, PubMed and Medline, were searched and higher levels of evidence I, II and III were included.

Results
There were 455 papers reviewed and 26 met the inclusion criteria. Furthermore, 19 of these studied respiratory interventions such as positive airway pressure and oxygen delivery. The remaining 7 examined: erythropoietin, caffeine, dexamethasone, protein supplementation, ribavirin, respiratory syncytial virus immune globulin, or diuretic therapy. Of the 26 studies, 20 excluded infants with high-risk conditions. Therapies showing favourable outcomes included Heliox, prophylactic dexamethasone pre-extubation, protein supplementation, and diuretic use.

Conclusions
Clinical trials for bronchiolitis management frequently exclude high-risk children. Innovative study design in the future may improve access to clinical trials for the management of bronchiolitis in high-risk infants in a PICU setting.

Impact

Clinical trials for bronchiolitis management frequently exclude high-risk children.

We review the evidence base for the management of an under-investigated patient demographic in the setting of acute bronchiolitis.

Randomised controlled trials are needed to determine the efficacy of management strategies for bronchiolitis in high-risk infants in a paediatric intensive care setting.
Late stage melanoma is hallmarked by low NLGN4X expression leading to HIF1A accumulation
Authors: Schörghofer David , Vock Laurenz , Mirea Madalina A. , Eckel Oliver , Gschwendtner Anna , Neesen Jürgen , Richtig Erika , Hengstschläger Markus , Mikula Mario 
Published: June 2024

Abstract
Background
Despite ongoing research and recent advances in therapy, metastatic melanoma remains one of the cancers with the worst prognosis. Here we studied the postsynaptic cell adhesion molecule Neuroligin 4X (NLGN4X) and investigated its role in melanoma progression.

Methods
We analysed histologic samples to assess the expression and predictive value of NLGN4X in human melanoma. The oncogenic role of NLGN4X was determined by loss or gain-of-function experiments in vitro as well as by analysis of tumorspheres, which were grafted to human skin organoids derived from pluripotent stem cells. Whole genome expression analysis and validation experiments were performed to clarify the molecular mechanism.

Results
We identified that suppression of NLGN4X down regulated the prefoldin member Von Hippel-Lindau binding protein 1 (VBP1). Moreover, loss of VBP1 was sufficient for accumulation of HIF1A and HIF1A signalling was further shown to be essential for the acquisition of migratory properties in melanoma. We re-established NLGN4X expression in late stage melanoma lines and observed decreased tumour growth after transplantation to human skin organoids generated from pluripotent stem cells. In line, we showed that high amounts of NLGN4X and its target VBP1 in human patient samples had a beneficial prognostic effect on patient survival.

Conclusion
In view of these findings, we propose that decreased amounts of NLGN4X are indicative of a metastatic melanoma phenotype and that loss of NLGN4X provides a novel mechanism for HIF induction.
Importations of SARS-CoV-2 lineages decline after nonpharmaceutical interventions in phylogeographic analyses
Authors: Goliaei Sama , Foroughmand-Araabi Mohammad-Hadi , Roddy Aideen , Weber Ariane , Översti Sanni , Kühnert Denise , McHardy Alice C. 
Published: June 2024

AbstractDuring the early stages of the SARS-CoV-2 pandemic, before vaccines were available, nonpharmaceutical interventions (NPIs) such as reducing contacts or antigenic testing were used to control viral spread. Quantifying their success is therefore key for future pandemic preparedness. Using 1.8 million SARS-CoV-2 genomes from systematic surveillance, we study viral lineage importations into Germany for the third pandemic wave from late 2020 to early 2021, using large-scale Bayesian phylogenetic and phylogeographic analysis with a longitudinal assessment of lineage importation dynamics over multiple sampling strategies. All major nationwide NPIs were followed by fewer importations, with the strongest decreases seen for free rapid tests, the strengthening of regulations on mask-wearing in public transport and stores, as well as on internal movements and gatherings. Most SARS-CoV-2 lineages first appeared in the three most populous states with most cases, and spread from there within the country. Importations rose before and peaked shortly after the Christmas holidays. The substantial effects of free rapid tests and obligatory medical/surgical mask-wearing suggests these as key for pandemic preparedness, given their relatively few negative socioeconomic effects. The approach relates environmental factors at the host population level to viral lineage dissemination, facilitating similar analyses of rapidly evolving pathogens in the future.
Plasma cell differentiation is regulated by the expression of histone variant H3.3
Authors: Saito Yuichi , Harada Akihito , Ushijima Miho , Tanaka Kaori , Higuchi Ryota , Baba Akemi , Murakami Daisuke , Nutt Stephen L. , Nakagawa Takashi , Ohkawa Yasuyuki , Baba Yoshihiro 
Published: June 2024

AbstractThe differentiation of B cells into plasma cells is associated with substantial transcriptional and epigenetic remodeling. H3.3 histone variant marks active chromatin via replication-independent nucleosome assembly. However, its role in plasma cell development remains elusive. Herein, we show that during plasma cell differentiation, H3.3 is downregulated, and the deposition of H3.3 and chromatin accessibility are dynamically changed. Blockade of H3.3 downregulation by enforced H3.3 expression impairs plasma cell differentiation in an H3.3-specific sequence-dependent manner. Mechanistically, enforced H3.3 expression inhibits the upregulation of plasma cell-associated genes such as Irf4, Prdm1, and Xbp1 and maintains the expression of B cell-associated genes, Pax5, Bach2, and Bcl6. Concomitantly, sustained H3.3 expression prevents the structure of chromatin accessibility characteristic for plasma cells. Our findings suggest that appropriate H3.3 expression and deposition control plasma cell differentiation.
Electrically driven spin resonance of 4f electrons in a single atom on a surface
Authors: Reale Stefano , Hwang Jiyoon , Oh Jeongmin , Brune Harald , Heinrich Andreas J. , Donati Fabio , Bae Yujeong 
Published: June 2024

AbstractA pivotal challenge in quantum technologies lies in reconciling long coherence times with efficient manipulation of the quantum states of a system. Lanthanide atoms, with their well-localized 4f electrons, emerge as a promising solution to this dilemma if provided with a rational design for manipulation and detection. Here we construct tailored spin structures to perform electron spin resonance on a single lanthanide atom using a scanning tunneling microscope. A magnetically coupled structure made of an erbium and a titanium atom enables us to both drive the erbium’s 4f electron spins and indirectly probe them through the titanium’s 3d electrons. The erbium spin states exhibit an extended spin relaxation time and a higher driving efficiency compared to 3d atoms with spin ½ in similarly coupled structures. Our work provides a new approach to accessing highly protected spin states, enabling their coherent control in an all-electric fashion.