bluuebunny/crossref_metadata_2025_split huggingface dataset:
Phase 2 study of dasatinib in the treatment of head and neck squamous cell carcinoma
Authors: Brooks Heather D. , Glisson Bonnie S. , Bekele B. Nebiyou , Ginsberg Lawrence E. , El‐Naggar Adel , Culotta Kirk S. , Takebe Naoko , Wright John , Tran Hai T. , Papadimitrakopoulou Vassiliki A. 
Published: November 2010

AbstractBACKGROUND:Treatment options for patients with advanced head and neck squamous cell carcinoma (HNSCC) are scarce. This phase 2 study was conducted to evaluate the safety, tolerability, pharmacokinetics, and efficacy of dasatinib in this setting.METHODS:Patients with recurrent and/or metastatic HNSCC after platinum‐based therapy were treated with dasatinib either orally or via percutaneous feeding gastrostomy (PFG). Primary endpoints were 12‐week progression‐free survival (PFS) and objective response rate with a 2‐stage design and early withdrawal if the 12‐week PFS rate was ≤20% and no patients had an objective response (OR). Forty‐nine serum cytokines and angiogenic factors (CAFs) were analyzed from treated patients.RESULTS:Of the 15 patients enrolled, 12 were evaluable for response, and all patients were evaluable for toxicity. No OR was observed and 2 patients (16.7%) had stable disease (SD) at 8 weeks. The median treatment duration was 59 days, the median time to disease progression was 3.9 weeks, and the median survival was 26 weeks. One patient required a dose reduction, 3 patients required dose interruptions, and 4 patients were hospitalized for toxicity. Dasatinib inhibited c‐Src both when administered orally and via PFG. Greater mean drug exposure, decreased half‐life, and greater maximum concentration were observed in patients receiving dasatinib via PFG. Eleven baseline CAFs were associated with treatment outcome and 1 CAF, macrophage migration inhibitory factor, was found to be differentially modulated in correlation with SD versus disease progression.CONCLUSIONS:Single‐agent dasatinib failed to demonstrate significant activity in patients with advanced HNSCC, despite c‐Src inhibition. The toxicity profile was consistent with that reported in other solid tumors, and the drug can be given via PFG tube. Cancer 2011. © 2010 American Cancer Society.
Etiologic role of human papillomavirus infection in bladder carcinoma
Authors: Shigehara Kazuyoshi , Sasagawa Toshiyuki , Kawaguchi Shohei , Nakashima Takao , Shimamura Masayoshi , Maeda Yuji , Konaka Hiroyuki , Mizokami Atsushi , Koh Eitetsu , Namiki Mikio 
Published: November 2010

AbstractBACKGROUND:The authors elucidated an etiologic role of human papillomavirus (HPV) infection in carcinoma of the bladder.METHODS:One hundred seventeen of 224 patients with bladder carcinoma who were treated between 1997 and 2009 were enrolled in this study. The presence of HPV DNA was tested on frozen carcinoma tissues that were obtained by transurethral resection using a polymerases chain reaction‐based method. Localization of HPV was observed on archival tissue specimens by in situ hybridization (ISH) for high‐risk HPV DNA. Cyclin‐dependent kinase (CDK) inhibitor 2A (inhibits CDK4) (p16‐INK4a) and minichromosome maintenance protein‐7 (mcm‐7)—surrogate markers for high‐risk HPV‐E7 oncoprotein—and HPV‐L1 (capsid) protein expression were evaluated by immunohistochemistry.RESULTS:HPV types 16, 18, 31, 33, 52, and 58, and an unknown HPV type were detected in 18 of 117 samples (15%) from patients with bladder carcinoma. HPV16 was identified in 6 samples, HPV18 was identified in 4 samples, and HPV33 was identified in 3 samples. All were single HPV type infections. HPV was detected in 38% (12 of 28) of histologic grade 1 bladder carcinomas, 8.5% (6 of 71) of grade 2 bladder carcinomas, and in 0% (0 of 18) of grade 3 bladder carcinomas. Multivariate analysis indicated that younger age (<60 years; odds ratio [OR], 10.9; 95% confidence interval [CI], 2.6‐45.3) and grade 1 tumors (OR, 4.5; 95% CI, 1.2‐17.0) were associated with HPV infection. ISH analysis indicated that high‐risk HPV DNA was localized in the nuclei of tumor cells of all HPV‐positive samples. p16‐INK4a and mcm‐7 were expressed in 94% and 89% of HPV‐positive carcinoma cells, respectively. HPV‐L1 protein expression, which suggested reproductive HPV infection, was not observed in any carcinoma.CONCLUSIONS:The current results indicated that high‐risk HPV is likely to be a causative agent of some low‐grade bladder carcinomas that develop in younger patients. Cancer 2011. © 2010 American Cancer Society.
Photolysis and Heterogeneous Reaction of Coniferyl Aldehyde Adsorbed on Silica Particles with Ozone
Authors: Net Sopheak , Alvarez Elena Gomez , Balzer Natalja , Wortham Henri , Zetzsch Cornelius , Gligorovski Sasho 
Published: November 2010

AbstractThe pseudo‐first‐order loss of coniferyl aldehyde, adsorbed on silicon dioxide particles, upon heterogeneous ozonolysis was monitored at various ozone mixing ratios in the absence and presence of simulated sunlight. For the first time we investigated the effect of light on the heterogeneous ozonolysis of coniferyl aldehyde adsorbed on silica particles. We found that UV–VIS light (λ>300 nm) does not impact the degradation of coniferyl aldehyde by ozone but induces an additional, slow photolysis of the aldehyde with a photolytic rate constant of ∼10−5 s−1. In both cases, that is, in presence and/or absence of light, the heterogeneous ozonation kinetics are well described by an immediate gas–surface reaction formalism with light‐independent rate constants of k2nd=(7.2±0.9)×10−19 cm3 molec−1 s−1 and (7.6±1.7)×10−19 cm3 molec−1 s−1 in the absence and presence of light, respectively. Five oxidation products: glycolic acid, oxalic acid, vanillin, vanillic acid and 3,4‐dihydroxybenzoic acid were identified and confirmed by their corresponding standards. Vanillin and vanillic acid absorb light in the region λ>300 nm and thus can further participate in the direct and indirect photolysis processes of atmospheric relevance. A reaction mechanism is proposed in order to elucidate the ozonolysis reaction and to explain the reaction products.
Neural control of gene recruitment in metazoans
Authors: Cabej Nelson R. 
Published: November 2010

AbstractGene recruitment played a critical role in metazoan evolution. Yet, there is no consensus on whether it is an accidental event or a result of an inherent “gene recruiting” mechanism. The prevailing opinion among biologists is that gene recruitment results from random changes in genes or their regulatory regions, but the supporting evidence is poor and controversial. Herein, I present a mechanism in which gene recruitment is a neurally determined event, an adaptive response to changes in environmental conditions. In support of the hypothesis, I present evidence on the manipulative expression of genes in the central nervous system, as well as neurally determined examples of gene recruitment in transgenerational developmental plasticity and in evolution of metazoans Developmental Dynamics 240:1–8, 2011. © 2010 Wiley‐Liss, Inc.
Glial cell adhesive molecule unzipped mediates axon guidance in Drosophila
Authors: Ding Zhao‐Ying , Wang Ying‐Hsuan , Luo Zhao‐Kai , Lee Huei‐Fang , Hwang Jaulang , Chien Cheng‐Ting , Huang Min‐Lang 
Published: November 2010

AbstractAxon guidance needs help from the glial cell system during embryogenesis. In the Drosophila embryonic central nervous system (CNS), longitudinal glia (LG) have been implicated in axon guidance but the mechanism remains unclear. We identified the protein encoded by the Drosophila gene unzipped (uzip) as a novel cell adhesion molecule (CAM). Uzip expressed in Drosophila S2 cells triggered cell aggregation through homophilic binding. In the embryonic CNS, Uzip was mainly produced by the LG but was also located at axons, which is consistent with the secretion of Uzip expressed in cultured cells. Although uzip mutants displayed no axonal defect, loss of uzip enhanced the axonal defects in the mutant of N‐cadherin (CadN) and the Wnt gene family member wnt5. Overexpression of uzip could rescue the phenotype in the CadNuzipD43 mutant. Thus, Uzip is a novel CAM from the LG regulating axon guidance. Developmental Dynamics, 2011. © 2010 Wiley‐Liss, Inc.
Transient stability evaluation method based on kinetic energy of postfault trajectories
Authors: Okuda Takahiro , Nakagawa Shinichi , Ohsaki Yuta , Iwamoto Shinichi 
Published: November 2010

AbstractIt is very important to maintain supply reliability in the deregulated environment. The transient stability problem is one of the major concerns in studies of planning and operation of power systems. Time domain simulation is currently the best available tool for allowing the use of detailed models and for providing reliable results. The main limitations of this approach involve long computation times. Therefore, this paper proposes a transient stability evaluation method using minimum transient kinetic energy of postfault trajectories. This method can estimate critical clearing times with only two points of the minimum transient kinetic energy, regardless of whether the trajectories after the clearing time are stable or unstable. The validity of the proposed method is shown by simulation studies with the IEEJ EAST 10‐machine 47‐bus system. © 2010 Wiley Periodicals, Inc. Electr Eng Jpn, 174(3): 18–24, 2011; Published online in Wiley Online Library (wileyonlinelibrary.com). DOI 10.1002/eej.21018
CVCF inverter based on nonlinear control of instantaneous active and reactive power and its operation characteristics
Authors: Sato Akira , Noguchi Toshihiko 
Published: November 2010

AbstractThis paper describes a direct‐power‐controlled CVCF inverter and presents its experimentally examined operation characteristics. The most important feature of this strategy is the direct selection of the switching states of the CVCF inverter to restrict errors between the feedback and command values of active and reactive power. In addition, this paper presents a theoretical analysis of the relationship between the instantaneous power and the switching state, which is essential for deriving a switching‐state table for the controller. The feasibility of the proposed method was verified through several computer simulations and experimental tests using a 2.0‐kVA prototype setup. The output voltages were confirmed to be stable sinusoidal waveforms with a total harmonic distortion of 1.13% under nonlinear load conditions. Excellent voltage balance was achieved by the proposed strategy even under unbalanced load conditions. © 2010 Wiley Periodicals, Inc. Electr Eng Jpn, 174(3): 62–69, 2011; Published online in Wiley Online Library (wileyonlinelibrary.com). DOI 10.1002/eej.21023
Active immunization using a single dose immunotherapeutic abates established EAE via IL‐10 and regulatory T cells
Authors: Rynda‐Apple Agnieszka , Huarte Eduardo , Maddaloni Massimo , Callis Gayle , Skyberg Jerod A. , Pascual David W. 
Published: November 2010

AbstractStimulation of Ag‐specific inducible Treg can enhance resolution of autoimmune disease. Conventional methods to induce Treg often require induction of autoimmune disease or subjection to infection. Reovirus adhesin, protein σ1 (pσ1), can successfully facilitate tolerance when fused to a tolerogen. We tested whether myelin oligodendrocyte glycoprotein (MOG) fused to pσ1 (MOG‐pσ1) can stimulate Ag‐specific Treg. We show that C57BL/6 mice treated nasally with MOG‐pσ1 fail to induce MOG‐specific Abs and delayed‐type hypersensitivity (DTH) responses and resist EAE. Such resistance was attributed to stimulation of Foxp3+ Treg, as well as Th2 cells. MOG‐pσ1's protective capacity was abrogated in IL‐10−/− mice, but restored when adoptively transferred with MOG‐pσ1‐induced Treg. As a therapeutic, MOG‐pσ1 diminished EAE within 24 h of nasal application, unlike recombinant MOG (rMOG), pσ1, or pσ1+rMOG, implicating the importance of Ag specificity by pσ1‐based therapeutics. MOG‐pσ1‐treated mice showed elevated IL‐4, IL‐10, and IL‐28 production by CD4+ T cells, unlike rMOG treated or control mice that produced elevated IFN‐γ or IL‐17, respectively. These data show the feasibility of using pσ1 as a tolerogen platform for Ag‐specific tolerance induction and highlight its potential use as an immunotherapeutic for autoimmunity.
Relaying results for indoor coverage in long‐term evolution and beyond
Authors: Venkatkumar V. , Haustein T. , Faulkner M. 
Published: November 2010

AbstractFuture cellular networks aim to improve the data rate to users in office and residential buildings. Wireless relaying is one of the possible solutions. In this approach, a relay is placed inside a building to get around the building penetration path loss. Decode and forward operation is employed for full re‐use of the licensed bandwidth with frequency dependent link adaptation. In this paper, we report indoor measurement results using state of the art macrocellular and relay. Orthogonal frequency division duplexing (OFDM) and multiple input multiple output (MIMO) are used in both links. The relay measurements were performed for a single cell three terminal relay network setup. Results show that (a) relay provides better data rate and coverage as compared to macro and (b) feedback can further improve relay coverage. A relay is able to deliver data rate exceeding 40 Mbps to locations well inside the building. Copyright © 2010 John Wiley & Sons, Ltd.
Cooperative feedback to improve capacity and error rate in multiuser diversity systems – an OFDM case study
Authors: Valentin Stefan , Karl Holger 
Published: November 2010

AbstractTo achieve multiuser diversity gains, resource allocation relies on accurate and timely feedback of the users' channel states. Obtaining such reliable feedback under tight overhead and delay constraints is non‐trivial in many wireless systems. To this end, we let users cooperate when transmitting feedback. Studying our cooperative feedback scheme exemplarily for the multiuser OFDM downlink shows that it efficiently avoids resource allocation errors. This significantly improves the error rate, ergodic sum capacity, or the system's energy efficiency even if the resources and energy required for cooperation are taken into account.
MicroRNA expression profiles of head and neck squamous cell carcinoma with docetaxel‐induced multidrug resistance
Authors: Dai Yuemeng , Xie Cheng‐hui , Neis John P. , Fan Chun‐Yang , Vural Emre , Spring Paul M. 
Published: November 2010

AbstractBackgroundThe purpose of this study was to investigate the potential role of variable microRNA (miRNA) expression in the development of multidrug resistance (MDR) in head and neck cancer.MethodsHead and neck squamous cell carcinoma cell lines UMSCC‐1 and SQ20B were treated with docetaxel at increasing concentrations to develop resistant cell lines. Parental and resistant cells were treated with cisplatin, 5‐fluorouracil, paclitaxel, methotrexate, and doxorubicin to confirm cross‐resistance. The miRNA pattern of resistant cells was then compared with their parental cells.ResultsDocetaxel treatment successfully induced resistance primarily and induced multidrug cross‐resistance. Resistant cells showed significant downregulation of miR‐100, miR‐130a, and miR‐197 and upregulation in miR‐101, miR‐181b, miR‐181d, and miR‐195 expression when compared with their parent cells (p < .01). Real‐time polymerase chain reaction (PCR) analysis confirmed statistically significant downregulation in miR‐100 and miR‐130a and upregulation in miR‐181d expression (p < .001).ConclusionAlterations in miRNA expression has direct relationship to MDR in head and neck cancer and may serve as biomolecular targets for reversal of MDR. © 2010 Wiley Periodicals, Inc. Head Neck, 2011
Value of fluorescence endoscopy for the early diagnosis of laryngeal cancer and its precursor lesions
Authors: Kraft Marcel , Betz Christian Stephan , Leunig Andreas , Arens Christoph 
Published: November 2010

AbstractBackgroundFluorescence endoscopy is used for the early detection and delineation of laryngeal cancer and its precursor lesions. No systematic review of these promising imaging techniques has yet been performed.MethodsA systematic review of the published literature and meta‐analysis of data extracted from 16 included studies were performed. A total of 1000 laryngeal lesions were examined by autofluorescence endoscopy (AFE), 318 mucosal changes by induced fluorescence endoscopy (IFE), and 679 laryngeal pathologies underwent normal white light endoscopy (WLE).ResultsIn identifying precancerous and cancerous lesions of the larynx, sensitivity (91% vs 73%), specificity (84% vs 79%), and accuracy (88% vs 77%) of AFE were superior to WLE alone, whereas IFE showed an even higher sensitivity (95% vs 73%) at the expense of specificity (62% vs 79%). Therefore, AFE also achieved a higher specificity (84% vs 62%) and accuracy (88% vs 76%) than did IFE in detecting these kinds of lesions. However, the sensitivity (91% vs 95%) did not differ significantly between both methods.ConclusionsThis meta‐analysis confirms that fluorescence endoscopy is highly effective in the early diagnosis of laryngeal cancer and its precursor lesions. Thus, AFE can be used immediately without drug administration or possible side effects, whereas IFE is more suited for the detection of recurrent disease following initial surgery. © 2010 Wiley Periodicals, Inc. Head Neck, 2011
Comparison of calcitriol versus cholecalciferol therapy in addition to oral calcium after total thyroidectomy with central neck lymph node dissection: A prospective randomized study
Authors: Choe Jun‐Ho , Kim Wan Wook , Lee Se‐Kyung , Lim Hye In , Choi Jae Hyuck , Lee Jeong Eon , Kim Jung‐Han , Nam Seok Jin , Yang Jung‐Hyun , Kim Jee Soo 
Published: November 2010

AbstractBackgroundThe purpose of this study was to determine the effectiveness of oral calcium plus vitamin D supplementation and to compare the effects of cholecalciferol versus calcitriol treatments on postoperative hypocalcemia.MethodsAfter total thyroidectomy with central neck dissection, 306 patients were divided into 4 groups according to “routine use versus on‐demand use” and “cholecalciferol versus calcitriol.”ResultsHypocalcemic symptoms developed in 101 patients (33.0%). Hypocalcemia developed less frequently in patients receiving routine supplementation regardless of vitamin D type. However, routine supplementation did not prevent severe hypocalcemia. In patients receiving on‐demand supplements, calcitriol was more effective and faster acting than was cholecalciferol.ConclusionRoutine oral calcium and vitamin D supplements are beneficial after total thyroidectomy with central neck lymph node dissection with no difference between cholecalciferol and calcitriol. If taken after the onset of hypocalcemia, however, calcitriol along with calcium carbonate seems to be more effective than is cholecalciferol with calcium carbonate. © 2010 Wiley Periodicals, Inc. Head Neck, 2010
Miyaura Borylations of Aryl Bromides in Water at Room Temperature
Authors: Lipshutz Bruce H. , Moser Ralph , Voigtritter Karl R. 
Published: November 2010

AbstractNew technology for palladium‐catalyzed cross‐couplings between B2pin2 and aryl bromides leading to arylboronates is described. Micellar catalysis serves to enable borylations to take place in water as the only medium at ambient temperatures.
Proteomic identification of CD44 interacting proteins
Authors: Skandalis Spyros S. , Kozlova Inna , Engström Ulla , Hellman Ulf , Heldin Paraskevi 
Published: November 2010

AbstractCD44 is a cell surface receptor for hyaluronan which affects cell adhesion and migration, and has been implicated in chronic inflammation and in tumorigenesis. To elucidate the molecular mechanisms underlying its multiple functions, we used a peptide‐based pull‐down assay to identify proteins that interact with CD44. Nonphosphorylated or phosphorylated peptides from the intracellular CD44 C‐terminus, were immobilized and used as baits. Interacting proteins were subjected to SDS‐gel electrophoresis and were identified by MALDI‐TOF mass spectrometry. Several interaction partners were identified, including proteins involved in cytoskeletal reorganization, transcription, endocytosis, and intracellular transport. An endogenous complex between CD44 and one of the interacting proteins, the actin binding protein IQGAP1, was demonstrated in several normal and transformed cell types. © 2010 IUBMB IUBMB Life 62(11): 833–840, 2010.
31P NMR and AFM studies on the destabilization of cell and model membranes by the major bovine seminal plasma protein, PDC‐109
Authors: Damai Rajani S. , Sankhala Rajeshwer S. , Anbazhagan Veerappan , Swamy Musti J. 
Published: November 2010

AbstractThe effect of PDC‐109 binding to dimyristoylphosphatidylcholine (DMPC) and dipalmitoylphosphatidylglycerol (DPPG) multilamellar vesicles (MLVs) and supported membranes was investigated by 31P NMR spectroscopy and atomic force microscopy. Additionally, the effect of cholesterol on the binding of PDC‐109 to phosphatidylcholine (PC) membranes was studied. Binding of PDC‐109 to MLVs of DMPC and DPPG induced the formation of an isotropic signal in their 31P NMR spectra, which increased with increasing protein/lipid ratio and temperature, consistent with protein‐induced disruption of the MLVs and the formation of small unilamellar vesicles or micelles but not inverse hexagonal or cubic phases. Incorporation of cholesterol in the DMPC MLVs afforded a partial stabilization of the lamellar structure, consistent with previous reports of membrane stabilization by cholesterol. AFM results are consistent with the above findings and show that addition of PDC‐109 leads to a complete breakdown of PC membranes. The fraction of isotropic signal in 31P NMR spectra of DPPG in the presence of PDC‐109 was less than that of DMPC under similar conditions, suggesting a significantly higher affinity of the protein for PC. Confocal microscopic studies showed that addition of PDC‐109 to human erythrocytes results in a disruption of the plasma membrane and release of hemoglobin into the solution, which was dependent on the protein concentration and incubation time. © IUBMB IUBMB Life, 62(11): 841–851, 2010.
Shared‐memory parallelization of the TURBOMOLE programs AOFORCE, ESCF, and EGRAD: How to quickly parallelize legacy code
Authors: van Wüllen Christoph 
Published: November 2010

AbstractThe programs ESCF, EGRAD, and AOFORCE are parts of the TURBOMOLE program package and compute excited‐state properties and ground‐state geometric hessians, respectively, for Hartree‐Fock and density functional methods. The range of applicability of these programs has been extended by allowing them to use all CPU cores on a given node in parallel. The parallelization strategy is not new and duplicates what is standard today in the calculation of ground‐state energies and gradients. The focus is on how this can be achieved without needing extensive modifications of the existing serial code. The key ingredient is to fork off worker processes with separated address spaces as they are needed. Test calculations on a molecule with about 80 atoms and 1000 basis functions show good parallel speedup up to 32 CPU cores. © 2010 Wiley Periodicals, Inc. J Comput Chem, 2011