bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Effect of Red Bean Juice and Butterfly Pea Extract on Flavonoid Content, Antioxidant Activity, and Sensory Quality of Stirred Yoghurt
Authors: Airin Felisha , Surono Ingrid Suryanti 
Published: April 2024

Abstract
This study aimed to determine the effect of adding red bean juice and butterfly pea extract to stirred yogurt on antioxidant activity, total flavonoids, and sensory properties. Preliminary research on total plate count was conducted, followed by antioxidant activity, total flavonoids, and sensory properties. Data analysis used one-way ANOVA, Tukey HSD, and the Pearson correlation test. The addition of 10% butterfly pea extract (A3), 10% red bean juice and 10% butterfly pea extract (A4) significantly increased the antioxidant activity. All treatments had a significant effect on the increase of total flavonoids, but significantly decreased the preference of colour. The addition of 10% butterfly pea extract (A3), 10% red bean juice and 10% butterfly pea extract (A4) significantly decreased overall preference. The addition of 10% red bean juice and 10% butterfly pea extract (A4) significantly decreased the preference of consistency as compared to the control.
The effects of roselle extract addition on physical properties and organoleptic preferences of sorghum noodles
Authors: Onasie Evie Wilona , Abadi Evelyne Elvania , Kristiana Angela , Lo Diana 
Published: April 2024

Abstract
This research is intended to study the effect of roselle extract addition on physical, hedonic preferences, and nutrition facts of the sorghum noodles. The research is conducted using a Completely Randomized Design one factor with the concentrations of roselle extract were 0%, 10%, 20%, 30%. The analysis conducted were water absorption, color value, and organoleptic analysis with one-way ANOVA test followed by Duncan’s Multiple Range Test for statistical analysis. The results showed that addition of roselle extract significantly affect the physical and organoleptic properties of sorghum noodles. The high concentration of roselle extract caused an increment in rehydration power, redness value, yellowness value, and decrement in lightness value. The rehydration power of sorghum noodles was 65 to 115%, lightness 43.10 to 63.78, redness -5.57 to 0.50, and yellowness 22.71 to 30.96. Based on the organoleptic preference test, roselle extract concentration of 30% has the best organoleptic properties with the liking scores of color, aroma, taste, texture, and overall liking of 3.40, 3.47, 3.50, 3.53, and 3.53, from the range of 1-5 respectively. From the nutrition fact prediction, sorghum noodle with 30% roselle extract has the higher calcium, and potassium than sorghum noodle without roselle extract. Therefore, 30% roselle extract addition on sorghum noodles showed was the best result in physical properties and organoleptic preferences.
Application of hesperidin crude extract from Siamese orange peel as an alternative natural antioxidant in the butter making process
Authors: Vivienne Clarissa , Amrinola Wiwit 
Published: April 2024

Abstract
Butter is a form of fat product that is quickly rancid. Reactions that cause rancidity can be prevented by adding synthetic antioxidant compounds. Behind that, the use of synthetic antioxidants triggers various side effects. Based on these problems, this study aimed to determine the effect of adding hesperidin crude extract from Siamese orange peel on the quality of the resulting butter product. In general, this research was divided into two parts: the isolation of the crude extract of hesperidin and the preparation and characterization of the final quality of butter. The crude extract of hesperidin showed positive for flavonoids and polyphenols. In general, the addition of hesperidin crude extract showed an effect by increasing the value of antioxidant activity and decreasing the peroxide value. The conclusion that can be obtained is the shelf life and the addition of hesperidin crude extract showed an effect on the final quality of butter. The best formulation in this study was the addition of 1.5% hesperidin crude extract. The formulation proved to have the highest value for antioxidant activity and the lowest value for peroxide value.
Antioxidant Activity and Consumer Acceptance Level of Kombucha Tea With Noni Fruit Extract (Morinda citrifolia)
Authors: Jennifer  , Surya R. 
Published: April 2024

Abstract
This study aimed to investigate the impact of fermentation time and the best formulation of black tea and noni fruit juice on the production kombucha with the highest hedonic value and antioxidant activity. The research method involved (1) preparing kombucha tea, (2) assessing antioxidant activity, Total Solids value, pH value of the sample, and (3) conducting statical analysis using One-Way ANOVA followed by Tukey’s Post Hoc Test at a confidence level a = 5% and T test. The addition of noni juice was found to increase the antioxidant activity in kombucha; however, it reduced the overall hedonic value of kombucha. In conclusion, this study determined that sample P2 (200 mL of noni juice in 800 mL of black tea) was the best formulation. Statistical tests revealed that both fermentation time and formulation P2 significantly influenced the increase in antioxidant activity, reaching 41.20%. Additionally, the highest hedonic score was achived by the control sample fermented for 7 days, which scored to 6.68%.
Utilization of Ginger and Its Waste
Authors: Sari D A , Saputro N W , Ulfa V S , Sukanta S , Wagiono W , Hasyim M 
Published: April 2024

Abstract
Ginger has become the focus of research because of its oleoresin and essential oil content. First, the drying process can maintain the quality of post-harvest products and increase the shelf life of dry products. Applying heat by air, microwave, vacuum, and freeze-drying can remove up to 5% (w.b.) of the moisture content of the material. High temperatures provide a greater driving force and result in the best possible product damage. The involvement of an adsorption dryer can be an opportunity to carry out drying at low temperatures by involving a dehumidified air agent. Apart from drying, the extraction process is an essential component of the ginger isolation technique. In addition to temperature, the physical properties involved in this process are density and pressure (having relatively great difficulty in achieving the desired properties). Significant components with GC-MS and GLC tests gave different peak area results from the drying and extraction processes. However, β-phellandrene and camphene represent the presence of ginger essential oil in both methods. Then, the pulp and skin can also be reprocessed through extraction to produce ginger oil and ginger pulp. The sustainability of ginger residue through pyrolysis can produce ginger charcoal products. Meanwhile, the ginger pulp contains sugar, acid, and micro-fibrillation of cellulose (MFC) through hydrolysis. The results of research related to ginger provide opportunities for SMEs to produce post-harvest products in red ginger powder. The extraction process with polar solvents and the role of appropriate technology have encouraged independent economic activities. In addition, dregs from raw materials and by-products can be exploited for opportunities to reduce the waste generated.
The Effect of Different Disinfectants for Controlling Salmonella Serotypes on Food Contact Surfaces: A Review
Authors: Bun Jasmine , Nugroho Galih 
Published: April 2024

Abstract
Salmonellosis is one of the most common foodborne infections worldwide. Various Salmonella enterica serotypes can cause this infection and can be transmitted through food contact surfaces. The most common way to prevent this infection is by applying disinfectant on food contact surfaces. Therefore, this research aims to summarize the effect of different disinfectants for controlling Salmonella serotypes on food contact surfaces. PRISMA guidelines were used as the method to find suitable sources for this systematic review. Relevant studies that were used are retrieved from several databases such as Science Direct, EBSCOhost, Taylor & Francis, SAGE, and Scopus. The keywords used to identify the relevant studies were “disinfectant”, “Salmonella sp.”, “food contact surface”, “food safety”, and “hygiene”. The initial search in the databases yielded 75 articles. After the screening process based on the criteria of the article, only 6 articles were used in the final systematic review. The result showed that the effect of disinfectants on foodborne pathogens, especially Salmonella serotypes, can be influenced by the composition of the disinfectant, the type of serotype, and the food contact surface material used. Therefore, in-depth consideration is needed regarding the factors that influence the effectiveness of a disinfectant, especially on food contact surfaces in the food industry.
Proximate, total phenolic, carotenoid, antioxidant activity, color, and FTIR analysis of red ginger powders (Zingiber officinale var. Rubrum) through the evaporation-crystallization process
Authors: Iqbal M , Sari D A , Saputro NW , Sukanta S , Hasyim M 
Published: April 2024

Abstract
Red ginger is a plant that is rich in antioxidants and is easily available in Indonesia. So far, red ginger has been used with various extraction methods by previous researchers, but the application of this process has not been able to be used by independent economic MSMEs. This research took place using evaporation-crystallization equipment as the main tool, accompanied by temperature variations (80 and 90°C) and granulated sugar as a crystallization agent (60 and 100%). The quality of the powdered red ginger product analyzed in this study showed good stability values for the fresh red ginger raw material before processing. The average value of the proximate content of red ginger products is 7.668; 12.116; 5.225; 0.422-1.708; 73.960% for moisture, ash, fat, protein, and carbohydrate content, respectively; and total glucose of 63.768 ppm. Meanwhile, the results of the phenolic and carotenoid content provide a significant reduction of up to 50%. The average content is 42.459 mg gallic acid/g; and 5.480 g respectively (including color - also a decrease in L, a, and b values) compared to the red ginger pulp raw material. The opposite value occurred in the DPPH antioxidant activity of red ginger pulp, the content of which was 2-3 times higher than fresh red ginger. These findings not only have an impact on the development of more health-beneficial food and beverage products but also encourage further understanding of the potential of bioactive compounds in ginger to support human well-being.
Towards a Holistic Understanding: Health Consciousness and Perceived Benefit in Consumer Choices of Hydroponic Products
Authors: Fahlevi Mochammad , Dandi Mochamad , Matroji Fajar Juanda , Asetya Dimvy Rusefani 
Published: April 2024

Abstract
Hydroponic products have emerged as a popular choice, particularly among urban populations opting for healthy food alternatives. This study aims to investigate the impact of health consciousness and perceived benefits on the purchase intention of hydroponic products. Additionally, it explores the mediating role of perceived benefits, concerning the Value-Based Consumer Decision Model. The study encompasses responses from 208 participants residing in Indonesia, obtained through snowball sampling techniques. The study utilizes structural equation modelling (SEM) methodology using SmartPLS 4 software. The findings elucidate the significant roles that health consciousness β 0.294 and perceived benefits β 0.393 play in shaping the purchase intention toward hydroponic products. Health consciousness as a crucial factor for perceived benefit β 0.483. This research delves deeper by developing a model to fill existing research gaps. It explores the mediating role of perceived benefit in influencing the relationship between health consciousness on purchase intention β 0.190, the model reveals that perceived benefit successfully mediates the influence of health consciousness on purchase intention. This research is novel in its application of the value-based consumer decision model to the consumer behavior associated with hydroponic products. It offers important implications for business practitioners in the hydroponic product sector, providing invaluable insights into the shifting market dynamics driven by an increasingly health-conscious and benefit-oriented consumer base.
Primer Design for Cloning of L-arabinose isomerase Gene from Arthrobacter psychrolactophillus into plasmid pET28a(+)
Authors: Nirwantono R. , Herawan David , Firdausa Salsabila , Nuryana Issa , Laksmi Fina Amreta , Pardamean B. 
Published: April 2024

Abstract
A novel putative L-arabinose isomerase (L-AI) called ApL-AI with the accession number WP_110486392.1 was successfully retrieved from Arthrobacter psychrolactophilus B7 genome (Accession: NZ_QJVC01000021.1) through genome mining analysis. This study aimed to obtain the L-AI gene from the Arthrobacter psychrolactophilus B7 genome and clone it into the pET28a(+) plasmid. The primers pair designed in this study successfully amplified the gene using 60 °C of PCR annealing temperature and supported the gene amplicon to insert into the pET28a(+) to form plasmid pET28a(+)-ApLAI. It was proved by the appearance of a 1557-bp amplification band on the gel electrophoresis. The sequencing analysis also revealed that the gene was inserted in the correct direction, with the gene positioned after the promoter and finished with a terminator. Therefore, the plasmid can be used to express the ApL-AI gene to produce the ApL-AI enzyme for downstream analysis and further prospecting.
Apennine Crossings
Authors: Havely Nick 
Published: April 2024

Abstract
Apennine Crossings follows a modern mountain route across Italy: that of the ‘Great Apennine Excursion’, while moving back and forth in time, from the Middle Ages to the Second World War and from pilgrims merchants and tourists to soldiers, partisans, and poets. It interweaves the stories of past travellers in the region with the narrative of a walk across the ridge of the Northern Apennines, visiting high passes, remote lakes, and ancient sanctuaries. The travellers’ stories are drawn from a wide range of published and unpublished sources (letters, journals, memoirs, poems) and they illustrate a number of themes: the social and religious culture of the Northern Apennines, the perceptions of mountains; the development of literary tourism; and the impact of twentieth-century warfare. The book includes twenty-four illustrations, with maps for the whole route and for the sections covered by each of the seven chapters.
Introduction
Authors: Havely Nick 
Published: April 2024

Abstract
The Introduction outlines the course of the GEA trail, and its landscape, explaining how and why the writer came to know and travel across this part of the Apennines. It presents the range of travellers whose stories cross the path and form most of the book’s narrative: from clerics and pilgrims to tourists and World War II combatants. It discusses motives for travel across the Apennines, the genres of travel writing that will be sampled here, the range of published and unpublished sources that will be drawn upon, and the structure of this book and its relationship to previous writing about travel and travellers.
Lunigiana
Authors: Havely Nick 
Published: April 2024

Abstract
The last main chapter of the book takes the writer and a companion into the region of the Lunigiana on the final three days of the GEA trail. In rain and mist they cross the high peaks between the Lagastrello Pass and the Lago Santo Parmense; then they follow the ridge to the Passo della Cisa and a final long day brings them in darkness to the end of the GEA at the Passo dei Due Santi. At the Lago Santo the early exploits of a famous partisan leader ‘Facio’ are memorialized and recalled here. The Passo della Cisa was one of the most important crossing points on the Apennines before the age of the autostrada and its history from medieval times to the twentieth century is given close attention. Finally the activities of partisans in western Lunigiana accompany the narrative on the last day of the journey.
On Sin
Authors: Schellenberg J L 
Published: April 2024

AbstractThis chapter formulates arguments from development against the Christian doctrine of sin. The Misdiagnosis Argument maintains that the worst human problem is not constituted by a pattern of bad actions and moral dispositions implicating all humans, but rather a complex condition involving pain, ignorance, and other factors. This means the doctrine of sin is false. The Limited Responsibility Argument holds that bad acts are generally determined or near-determined. Since the doctrine of sin assigns a degree of moral responsibility for bad actions that is greater than this would allow, it is false. The Counterexample Argument shows that, on one interpretation, the doctrine of sin entails that all humans have believed in the existence of God, and on another, that all humans are in a profoundly disordered condition marked by self-oriented desire. But we have learned of various facts offering counterexamples to both entailments. Hence they, and the doctrine of sin, are false.
On Salvation
Authors: Schellenberg J L 
Published: April 2024

AbstractThis chapter identifies what’s minimally involved in the doctrine of salvation, and formulates two arguments from development against it. These arguments are united by the thought that, in the case of our relations to each other, salvation would require access to information humans have recently come to possess but that was not made available through Christ, which means that the doctrine is false. According to the Unsatisfied Factual Requirements Argument, a whole-making reordering of human relations requires access to a variety of ordinary facts, access which was not made available through Christ. The Gender/Sexuality Benightedness Argument focuses on information needed to make right what has gone deeply wrong among us, which includes the oppression of women and of LGBT people. False views about such people have prevailed across many centuries, and Christian teaching has been complicit in this. Thus again a requirement of salvation was not made available through Christ.
Erasure and Assertion in Body Aesthetics: Respectability Politics to Anti-Assimilationist Aesthetics
Authors: Martin-Seaver Madeline 
Published: April 2024

Abstract
Marginalized people have used body aesthetic practices, such as clothing and hairstyles, to communicate their worth to the mainstream. One such example is respectability politics, a set of practices developed in post-Reconstruction black communities to prevent sexual assault and convey moral standing to the white mainstream. Respectability politics is an ambivalent strategy. It requires assimilation to white bourgeois aesthetic and ethical standards, and so guides practitioners toward blandness and bodily erasure. Yet, it is an aesthetic practice that cultivates moral agency and helps communities avoid violence and meet social and economic goals. I contrast respectability politics with the anti-assimilationist body aesthetics of Chike Jeffers and Janell Hobson. Because these accounts do not seek to neutralize or erase the body, they fundamentally value black people. As such, they more effectively convey personhood than assimilationist strategies do and also demonstrate the positive role that body aesthetics can play in everyday ethical projects.
Synthesis of the A/D/E-ring Core Compounds of Maoecrystal V
Authors: Asao Hiroki , Shimasaki Yasuharu , Sasaki Ayaka , Katayama Shunki , Ida Kousuke , Kotake Masaaki , Sato Eriko , Sato Yuki , Ishimoto Taiki , Izumi Minoru , Vavricka Christopher J , Kuwahara Shigefumi , Kiyota Hiromasa 
Published: April 2024

Abstract
Synthesis of the A/D/E-ring core compounds of maoecrystal V was achieved. The key Diels-Alder reactions between tricyclic α-methylene lactones and Kitahara-Danishefsky dienes afforded the spirocyclic core compounds in a regioselective and stereoselective manner.
A comparative benchmarking and evaluation framework for heterogeneous network-based drug repositioning methods
Authors: Li Yinghong , Yang Yinqi , Tong Zhuohao , Wang Yu , Mi Qin , Bai Mingze , Liang Guizhao , Li Bo , Shu Kunxian 
Published: April 2024

Abstract
Computational drug repositioning, which involves identifying new indications for existing drugs, is an increasingly attractive research area due to its advantages in reducing both overall cost and development time. As a result, a growing number of computational drug repositioning methods have emerged. Heterogeneous network-based drug repositioning methods have been shown to outperform other approaches. However, there is a dearth of systematic evaluation studies of these methods, encompassing performance, scalability and usability, as well as a standardized process for evaluating new methods. Additionally, previous studies have only compared several methods, with conflicting results. In this context, we conducted a systematic benchmarking study of 28 heterogeneous network-based drug repositioning methods on 11 existing datasets. We developed a comprehensive framework to evaluate their performance, scalability and usability. Our study revealed that methods such as HGIMC, ITRPCA and BNNR exhibit the best overall performance, as they rely on matrix completion or factorization. HINGRL, MLMC, ITRPCA and HGIMC demonstrate the best performance, while NMFDR, GROBMC and SCPMF display superior scalability. For usability, HGIMC, DRHGCN and BNNR are the top performers. Building on these findings, we developed an online tool called HN-DREP (http://hn-drep.lyhbio.com/) to facilitate researchers in viewing all the detailed evaluation results and selecting the appropriate method. HN-DREP also provides an external drug repositioning prediction service for a specific disease or drug by integrating predictions from all methods. Furthermore, we have released a Snakemake workflow named HN-DRES (https://github.com/lyhbio/HN-DRES) to facilitate benchmarking and support the extension of new methods into the field.
Guided diffusion for molecular generation with interaction prompt
Authors: Wu Peng , Du Huabin , Yan Yingchao , Lee Tzong-Yi , Bai Chen , Wu Song 
Published: April 2024

Abstract
Molecular generative models have exhibited promising capabilities in designing molecules from scratch with high binding affinities in a predetermined protein pocket, offering potential synergies with traditional structural-based drug design strategy. However, the generative processes of such models are random and the atomic interaction information between ligand and protein are ignored. On the other hand, the ligand has high propensity to bind with residues called hotspots. Hotspot residues contribute to the majority of the binding free energies and have been recognized as appealing targets for designed molecules. In this work, we develop an interaction prompt guided diffusion model, InterDiff to deal with the challenges. Four kinds of atomic interactions are involved in our model and represented as learnable vector embeddings. These embeddings serve as conditions for individual residue to guide the molecular generative process. Comprehensive in silico experiments evince that our model could generate molecules with desired ligand–protein interactions in a guidable way. Furthermore, we validate InterDiff on two realistic protein-based therapeutic agents. Results show that InterDiff could generate molecules with better or similar binding mode compared to known targeted drugs.