bluuebunny/crossref_metadata_2025_split huggingface dataset:
Rare genotypes of protein Z gene are a risk factor for premature myocardial infarction but not protein Z plasma level
Authors: Soria Claudine , dit Sollier Claire , Borg Jeanne-Yvonne , Coudert Mathieu , Montalescot Gilles , Esposito Gaétan , Drouet Ludovic , Collet Jean-Philippe , Le Cam-Duchez Véronique 
Published: May 2009

SummaryProtein Z (PZ) is the cofactor of PZ dependent inhibitor (ZPI) that inhibits activated coagulation factor X. PZ was expected to play a role in coronary artery disease (CAD) but with inconsistent clinical findings. We therefore evaluated whether PZ plasma level and/or three genetic variants encoding for low PZ plasma level were associated with premature CAD in stable young post-myocardial infarction (MI) patients. PZ plasma level and three polymorphisms A-13G, G-103A and G79A were determined in 176 young stable post-MI patients and in 176 sex- and age-matched controls (FITE-NAT population). Moreover the genotypes, resulting from the combination of the three polymorphisms (A-13G/G-103A/G79A), were studied. PZ plasma level and the number of patients disclosing a PZ deficiency did not differ between post-MI patients and controls. The presence of the mutated allele for each polymorphism was associated with a significantly reduced level of PZ. The A-13G polymorphism was associated with premature CAD only in univariate analysis. Whereas, the presence of rare genotypes of PZ gene was an independent risk factor for premature CAD. In conclusion, PZ plasma level is not a key player in the pathophysiology of premature coronary artery disease. But, rare genotypes of PZ gene were found to be associated with premature CAD.
Recent developments in topical thrombins
Authors: Ortel Thomas L. , Kessler Craig M. 
Published: May 2009

SummaryManaging blood loss is part of the surgeon’s responsibility during surgical procedures, and a variety of therapeutic strategies are available to help accomplish this. Topical haemostatic agents are among the agents used to control surgical bleeding and locally arrest blood flow. Bovine thrombin is a commonly used topical haemostatic agent; however, its use has been associated with potential risks, including well-documented cases of antibodymediated coagulopathy. This coagulopathy develops as a consequence of antibody formation directed against bovine thrombin, other bovine coagulation proteins, and their human orthologs. The fact that a coagulopathy can result in association with the use of bovine plasma-derived thrombin preparations prompted the FDA to require pharmaceutical companies to place a black-box warning in their prescribing information for products containing bovine plasma-derived thrombin. Recently, human plasma-derived thrombin and recombinant human thrombin have been approved by the FDA with the expectation that they will be less immunogenic than the bovine-derived product. In clinical studies, purified human plasma-derived thrombin and recombinant thrombin have demonstrated equivalent efficacy and safety, with improved immunogenicity profiles compared with bovinederived thrombin agents. Well-designed and adequately powered clinical trials should be conducted to indicate whether human thrombin products would improve the risk-benefit and costbenefit profiles for surgeries complicated by excessive bleeding.
Accuracy of complete compression ultrasound in ruling out suspected deep venous thrombosis in the ambulatory setting
Authors: Sevestre Marie-Antoinette , Casez Pierre , Bressollette Luc , Taiar Mébarka , Pernod Gilles , Quéré Isabelle , Bosson Jean-Luc , Labarère José 
Published: May 2009

SummaryEvidence on the safety of complete compression ultrasound for ruling out deep venous thrombosis (DVT) is derived from studies conducted in tertiary care centers, although most patients with suspected DVT are managed in the ambulatory office setting. It was the objective of this study to estimate the rate of venous thromboembolism when anticoagulant therapy is withheld from ambulatory patients with normal findings on a single complete compression ultrasound. As part of a prospective cohort study, 3,871 ambulatory patients with clinically suspected DVT were enrolled by 255 board-certified vascular medicine physicians practicing in private offices in France. Compression ultrasound of the entire lower extremities was performed using a standardised examination protocol. Anticoagulant therapy was withheld from patients with negative findings on compression ultrasound, and 1,254 of them were randomly selected for follow-up. The main outcome measure was the three-month incidence of symptomatic venous thromboembolic events confirmed by objective testing. DVT was detected in 1,023 patients (26.4%),including 454 (11.7%) and 569 (14.7%) cases of proximal and isolated distal DVT, respectively. Of the 1,254 patients with negative results sampled for follow-up, six received anticoagulant therapy during follow-up and five were lost to follow-up. Five of 1,243 patients (0.4%, 95% confidence interval [CI], 0.1–0.9) experienced non-fatal symptomatic venous thromboembolic events (pulmonary embolism in two patients and DVT in three patients) and eight of 1,254 patients (0.6%, 95% CI, 0.3–1.2) died during the three-month follow-up. In conclusion, anticoagulant therapy can be safely withheld after negative complete compression ultrasound without further testing in the ambulatory office setting.
Binding of plasma factor XIII to thrombin-receptor activated human platelets
Authors: Nagy Béla , Simon Zsuzsa , Bagoly Zsuzsa , Muszbek László , Kappelmayer János 
Published: May 2009

SummaryPlatelet-bound coagulation factor XIII (FXIII) is targeted and concentrated at the site where platelet-rich thrombi are formed. Previous studies were in disagreement about the nature of FXIII binding to platelets. In this study, thrombin-receptor activating peptide (TRAP)-stimulated human whole blood and washed platelets were analysed by flow cytometry for the binding of FXIII using a monoclonal antibody against the A subunit of FXIII (FXIII-A). Here, we demonstrate that FXIII-A positivity significantly increased on activated platelets in whole blood compared to unstimulated sample, but not in washed platelets. GPIIb/IIIa receptor plays an essential role in FXIII binding, as fibrinogen receptor antagonist eptifibatide and fibrinogen binding inhibitor RGDS tetrapeptide significantly prevented the binding of FXIII. Furthermore, stimulated platelets from a patient with severe type I Glanzmann thrombasthenia showed insignificant FXIII-A positivity versus healthy controls. In addition, basal negligible amount of FXIII on washed platelets was only slightly increased when highly purified plasma FXIII (FXIII-A2B2) was added upon platelet activation by TRAP. Similarly, no remarkable FXIII-A positivity was observed when we used FXIII-A2B2 with γA/γA fibrinogen. However, γA/γ' fibrinogen significantly augmented FXIII binding on TRAP-stimulated platelets in the presence of non-activated FXIII-A2B2. We conclude that FXIII-A2B2 of plasma origin binds to thrombin-receptor activated platelets via GPIIb/IIIa receptor-bound fibrinogen with γ’-chain and is not capable of direct platelet binding.
Response to aspirin in healthy individuals
Authors: Pharand Chantal , Lordkipanidzé Marie , Sia Ying , Merhi Yahye , Diodati Jean , Blais Normand 
Published: May 2009

SummaryVariable biological effect of aspirin is suggested to be related to pharmacological resistance. The incidence of this so-called “resistant” state varies with the study population and the assay used. We determined performance features of five assays used to assess aspirin effects in non-smoking healthy volunteers not taking any drug known to interfere with platelet function. Blood and urine samples were obtained immediately before and after 8–10 days of aspirin 80 mg intake. Forty-five participants 19–59 years old were enrolled. The sensitivity (SE), specificity (SP), and optimal cut-off (CO) value to detect the effect of aspirin were: light transmission aggregometry (LTA) with 1.6 mM arachidonic acid (AA) – SE 100%,SP 95.9%,CO 20%;LTA with adenosine diphosphate (ADP) 10 µM – SE 84.4%, SP 77.8%, CO 70%; Ver-
VKORC1 deficiency in mice causes early postnatal lethality due to severe bleeding
Authors: Spohn Gabriele , Kleinridders Andre , Wunderlich F. Thomas , Watzka Matthias , Zaucke Frank , Blum-bach Katrin , Geisen Christof , Seifried Erhard , Müller Clemens , Paulsson Mats , Brüning Jens , Oldenburg Johannes 
Published: May 2009

SummaryVitamin K hydroquinone is oxidised to the epoxide form (K>O) during vitamin K-dependent posttranslational γ-glutamyl carboxylation resulting in biological active so called vitamin K-dependent proteins. In turn, K>O is reduced by the enzyme VKORC1 (vitamin K epoxide reductase complex component 1) to complete the vitamin K cycle. To investigate the biological role of VKORC1 in vivo, we generated VKORC1 knockout mice. Homozygous VKORC1-deficient mice developed normally until birth. Within 2–20 days after birth, the knockout mice died due to extensive, predominantly intracerebral haemorrhage. Bleeding resulted from a severe deficiency of γ-carboxylated clotting factors. This lethal phenotype could be rescued by oral administration of vitamin K. Additionally, morphometric analysis of the limbs in VKORC1-deficient animals revealed reduced length of bone calcification relative to wild-type control mice. The observed phenotype of VKORC1 knockout mice excludes the existence of other enzymes with VKOR activity that can substitute to supply vitamin K hydroquinone required for maturation of blood clotting factors. Thus, our study underscores the essential role of VKORC1 in vitamin K-dependent γ-glutamyl carboxylation.
The Importance of Being Southern: The Making of Policies of Immigration Control in Italy
Authors: Finotelli Claudia , Sciortino Giuseppe 
Published: May 2009

AbstractThe distinction between 'weak' Southern European and 'strong' Northern European migration regimes has often been used to explain the shortcomings of Italian immigration policies. This article challenges such a bipolar perspective, by analyzing Italy's evolution as an immigration country beyond the so-called the 'Southern' regime stereotype. We show that the unsatisfactory outcomes of Italian mechanisms of immigration controls are not necessarily the epiphany of a weak policy apparatus. We argue that they are the result of a much more complex mix of factors shaping Italian immigration policies since the 1980s: unrealistic policy goals, contradictory international pressures, structural internal constraints and fragile party coalitions.
Spain, the Cheap Model. Irregularity and Regularisation as Immigration Management Policies
Authors: González-Enríquez Carmen 
Published: May 2009

AbstractThe article examines the development of a migration policy in Spain and the criteria, preferences, interests and pressures that have shaped it, highlighting the role of compassionate feelings, a free-market approach, inexperience and the lack of administrative resources. Faced with the continuous, large-scale, unplanned and unexpected arrival of immigrants since 2000, governments have fluctuated from extraordinary regularisation measures and retreat to control policies. A proactive policy has never been fully implemented and irregularity has been the feature of most immigration. During the years of strong economic growth, immigrants were able to integrate in the labour market while the dominant political culture of permissiveness towards illegality, a relatively positive social attitude towards immigrants and the granting of broad social rights to foreigners irrespective of their legal status, all combined to produce a smooth integration process. However, the model came to an end when the economic crisis, made evident in 2008, caused a substantial increase in unemployment, especially among immigrants, prompting a political and social reaction against new immigration and the hardening of legal and administrative measures.
Legal Trends in Western Europe Related to Freedom of Religion
Authors: Berger Maurits 
Published: May 2009

AbstractFreedom of religion is not a static concept, especially not when religion becomes an increasingly dominant actor in the social and political field. This is particularly the case in Western Europe, where legal systems based on different forms of secularism are confronted with increasing religiosity among its indigenous people and large numbers of migrants. The author discerns four legal trends resulting from this confrontation, ranging from engaging religion to rebutting it: state involvement with religious authorities and activities; active state promotion of organization of religious communities (in particular Muslims); the protection of religion rather than its believers; and curbing religious behavior by law.
Harmonizing Particularity of Religions and Universality of Human Rights: Critique of Traditional 'Top Down' Approach and Proposed Alternative
Authors: Schubert Lara 
Published: May 2009

AbstractThis article is a response to the traditional discourse of human rights and religion as it addresses the charge of impossibility of universal human rights due to particularity of religious traditions. This traditional top-down approach is shown to be lacking in several respects. A bottom-up methodology is proposed, inspired by feminist thinkers. This alternative methodology does not separate religion but suggests that people with their religious convictions continuously redefine human rights. It includes recommendations for implementation. This process allows for more complete participation and support and has greater potential to lay the groundwork for the realization of human rights.
Diastereoselective Coupling of 1,3-Diene, Ketone, and Organometallic Reagents by Nickel Catalyst: Stereoselective Construction of Tetrasubstituted Carbon Centers
Authors: Saito Nozomi , Yamazaki Tetsuro , Sato Yoshihiro 
Published: May 2009

Abstract
A nickel-catalyzed three-component coupling of 1,3-diene, ketone, and organoboron or organosilicon reagents was investigated. While the coupling reaction using PhB(OH)2 afforded a 1,3-syn-substituted 4-penten-1-ol derivative as a single diastereomer, the reaction in the presence of tetraorganosilicon reagent under similar conditions exclusively produced the corresponding 1,3-anti isomer. In both reactions, a tetrasubstituted carbon center was constructed in a highly diastereoselective manner.
Experimental Study of SOF Oxidation Catalysts under Plasma Discharge Conditions
Authors: Yamamoto Shin , Yao Shuiliang , Kodama Satoshi , Mine Chieko , Fujioka Yuichi 
Published: May 2009

Abstract
Oxidative activities of eight different transition-metal oxides and two different noble metals toward the soluble organic fraction (SOF) in diesel particulate matter (PM) have been investigated under plasma discharge conditions. The oxidation rate with ZnO has shown the highest value 99% higher than that without a catalyst and has exceeded that with noble metals. A mechanism of catalytic SOF oxidation under plasma discharge conditions has been proposed.
Preparation, Crystal Structure, and Solid-state Fluorescence of a CH2Cl2-solvated Crystal of 6,13-Bis(t-butylphenyl)-2,3,9,10-tetrapropoxypentacene
Authors: Kitamura Chitoshi , Naito Takao , Yoneda Akio , Kobayashi Takashi , Naito Hiroyoshi , Komatsu Toshiki 
Published: May 2009

Abstract
Slow evaporation of 6,13-bis(t-butylphenyl)-2,3,9,10-tetrapropoxypentacene in CH2Cl2 solution in the dark, yielded CH2Cl2-solvated single crystals easily. The crystals were characterized by X-ray analysis and solid-state fluorescence.
Spin-crossover Transition in a Mesophase Iron(II) Thiocyanate Complex Chelated with 4-Hexadecyl-N-(2-pyridylmethylene)aniline
Authors: Oso Yuya , Ishida Takayuki 
Published: May 2009

Abstract
The title compound was a high-spin molecule for a morph as synthesized but exhibited a spin-crossover transition at 176 K in its mesophase after annealing above the mesophase transition at 353 K. The hexyl derivative in place of the hexadecyl group showed a reversible spin-crossover at 117 K, while the unsubstituted derivative had a sturdy high-spin state.
Gel–Flocculation Transition of a Supramolecular Hydrogel Induced by Depletion Effect of Polymers
Authors: Masuda Mitsutoshi , Sumitomo Keiko , Minamikawa Hiroyuki , Kameta Naohiro , Yamaguchi Yoshinori , Shimizu Toshimi 
Published: May 2009

Abstract
Upon addition of hydroxyethyl cellulose, a supramolecular hydrogel from a bolaamphiphilic molecule showed significant flocculation. Microscopic and spectroscopic observations revealed that the phenomenon was ascribable to polymer-induced depletion flocculation of the self-assembled fibril networks into the tape bundles.
Preparation of Thin Macroporous TiO2 Films Using PMMA Microspheres and Their Photoinduced Hydrophilicities
Authors: Kamegawa Takashi , Suzuki Norihiko , Yamashita Hiromi 
Published: May 2009

Abstract
Thin macroporous TiO2 films were successfully prepared on quartz substrate by a dip-coating method using poly(methyl methacrylate) (PMMA) microspheres as template. SEM observations as well as other spectroscopic measurements revealed that the thin TiO2 films with uniform macropores were formed on quartz substrate with relatively high transparency and anatase crystalline structures. It was also found that the photoinduced hydrophilicity under UV light as well as the durability of hydrophilic surface in the dark was enhanced on thin macroporous TiO2 films.
Magnetic Properties of Iron(II) and Cobalt(II) Complexes of Tetrakis(2-pyridyl)methane. Spin-crossover Behavior in the Cobalt(II) Complex
Authors: Ishikawa Ryuta , Matsumoto Kouzou , Onishi Koji , Kubo Takashi , Fuyuhiro Akira , Hayami Shinya , Inoue Katsuya , Kaizaki Sumio , Kawata Satoshi 
Published: May 2009

Abstract
Iron(II) and cobalt(II) mononuclear metal complexes with tetrakis(2-pyridyl)methane have been synthesized and characterized. A gradual spin-crossover to the high-spin state above 300 K is observed in the cobalt(II) complex while the iron(II) complex exhibits no spin transition to the high-spin state between 5 and 400 K.
Synthesis of Hydroxyapatite–Zeolite Composite Material from Disposed Steel Slag and Investigation of Its Structural and Physicochemical Characteristics
Authors: Kuwahara Yasutaka , Ohmichi Tetsutaro , Kamegawa Takashi , Mori Kohsuke , Yamashita Hiromi 
Published: May 2009

Abstract
Steel slag is a commercial waste material mainly containing SiO2, Al2O3, and CaO which are the chemical components of zeolite and hydroxyapatite (HAP), respectively. From the steel slag, a hydroxyapatite–zeolite composite material (HAP–ZE) was successfully synthesized in a one batch system by adding H3PO4 and NaOH. The structural characteristics of HAP–ZE were investigated by XRD, SEM, and N2 adsorption. From the adsorption of VOCs, HAP–ZE was found to have adsorption properties comparable to those of pure zeolite and HAP.
Dual Functionalization of Allene: Facile Construction of Heteropolycycles Mediated by Brønsted Acid
Authors: Mori Keiji , Sueoka Shosaku , Akiyama Takahiko 
Published: May 2009

Abstract
A facile construction of a heteropolycyclic framework is developed by exploiting the dual functionalization of allene. On treatment of phenethyl alcohol or amine bearing a terminal allene with the Brønsted acid, two consecutive reactions to allene, nucleophilic addition of heteroatom and the Friedel–Crafts reaction, occurred to give 2-oxa- or azabicyclo[2.2.2]octane skeleton.
Linguistic strategies and markedness in Estonian morphology
Authors: Ehala Martin 
Published: May 2009

Abstract
Estonian has features characteristic to both agglutinative and inflectional languages. The paper outlines in more detail the standing of different morphological subsystems on the inflective  agglutinative  analytic scale and characterises the strategies Estonian uses to express the values for some core grammatical categories. It is concluded that Estonian verbal morphology is more agglutinative than nominal and adjectival morphology. The somewhat weaker grammaticalisation of verbal morphology indicates that Estonian is not action oriented, but rather object-oriented. The well grammaticalised moods, particularly the ones expressing evidentiality and a rather weakly grammaticalised tense and missing aspect further characterises Estonian verbal morphology as conversationally rather than temporarily organised.
Estonian grammar between Finnic and SAE: some comparisons
Authors: Metslang Helle 
Published: May 2009

Abstract
Estonian has in the course of historical changes become more distant from the other Finnic languages and has acquired some features of Indo-European and/or Standard Average European. The article compares some structural features between Estonian, Finnish, Standard Average European, and German and Russian. Estonian and Finnish have grown apart typologically while retaining their main structure and are to the same extent peripheral with regard to SAE. At the same time there are some morpho-syntacic features where Estonian has become more distant from Finnish not in the direction of SAE but in the direction of German or Russian. In both languages the central SAE features are represented on a more moderate scale than the secondary features. Both languages, especially Estonian, reveal some tendencies towards SAE features.
Acquisition of Estonian: some typologically relevant features
Authors: Argus Reili 
Published: May 2009

Abstract
Most previous approaches to the acquisition of morphology have focused on the acquisition of inflectional morphology of some Indo-European language; there are fewer studies on the acquisition of languages with a rich morphological system, in-cluding the Finno-Ugric languages. Among the Finno-Ugric languages the acquisition of Estonian has been a largely neglected area. The article discusses the impact of the typological peculiarity of a language on the acquisition of the inflectional morphology of Estonian. At first some assumptions will be made concerning the impact of the general richness of the Estonian morphological system on the speed of the acquisition of inflectional morphology followed by the analyses of the acquisition of individual typologically relevant features. The article discusses the acquisition of inflectional and analytic means of expression, the acquisition of gradation as a typologically relevant feature of Estonian, the acquisition of the lexical aspect of Estonian, and the acquisition of the case of the object as the principal means of expressing the aspect. The conclusions are based on the data from the previous articles by the author and the Estonian subcorpus of Vija, Argus, and Triplets in CHILDES.
Dynamics of Estonian phonology
Authors: Pajusalu Karl 
Published: May 2009

Abstract
The sound system of the Estonian language reveals a number of peculiar features untypical of the Finno-Ugric languages. The development of these features has been influenced by language contacts in the circum-Baltic linguistic area. Even today one can notice a number of systematic changes in Estonian phonology, the causes of which could be explained by language contacts, but the realization of which follows typological constraints of the language structure. The article focuses on such innovations in Estonian vowel and consonant systems, and prosody.