bluuebunny/crossref_metadata_2025_split huggingface dataset:
Validated RP‐HPLC/UV method for the quantitation of abiraterone in rat plasma and its application to a pharmacokinetic study in rats
Authors: Kumar S. Vijay , Rudresha G. , Gurav Sandip , Zainuddin Mohd , Dewang Purushottam , Kethiri Raghava Reddy , Rajagopal Sriram , Mullangi Ramesh 
Published: July 2012

ABSTRACTA novel, simple, specific, sensitive and reproducible high‐performance liquid chromatography (HPLC) assay method has been developed and validated for the estimation of abiraterone (ART) in rat plasma. The analytical procedure involves extraction of ART and diclofenac (internal standard, IS) from rat plasma with a simple liquid–liquid extraction process. The chromatographic analysis was performed on a Waters Alliance system with a Betasil C18 column maintained at ambient room temperature and an isocratic mobile phase [acetonitrile–water–10 mm potassium dihydrogen phosphate (pH 3.0), 55:5:40, v/v/v] at a flow rate of 1.00 mL/min with a total run time of 10 min. The eluate was monitored using an UV detector set at 255 nm. Method validation was performed as per FDA guidelines and the results met the acceptance criteria. The calibration curve was linear over a concentration range of 93.4–3251 ng/mL (r2 = 0.997). The intra‐ and inter‐day precisions were 0.56–4.98 and 3.03–7.18, respectively, in rat plasma. The validated HPLC method was successfully applied to a pharmacokinetic study of ART in rats. Copyright © 2012 John Wiley & Sons, Ltd.
Parameter Selection of Emulsification Processes: Conditions for Nano‐ and Macroemulsions
Authors: El Kinawy O. S. , Petersen S. , Helmdach L. , Ulrich J. 
Published: July 2012

AbstractBeside factors like nature of the emulsifier as well as rheology of the interface and continuous phase, the droplet size distribution of an emulsion governs emulsion properties such as long‐term stability over months or years, texture, and optical appearance. Consequently, emulsions with droplets in nano‐scale are of interest when well‐defined emulsion properties are needed. The formation of emulsions consisting of water, corn oil, and nonionic surfactants using disc systems and high‐pressure homogenizers was studied. The emulsion droplet size distributions were obtained by means of a laser diffraction method. The influence of parameters affecting the emulsion formation, such as emulsification time, viscosity for the disc system, pressure, and homogenizing steps for high‐pressure homogenization, was investigated. Data to determine the effect of the surfactant type and concentration were collected for both systems. The emulsification process using a disc system was evaluated in order to highlight its advantages and limits in comparison to high‐pressure homogenization.
Photocaging Strategy for Functionalisation of Oligonucleotides and Its Applications for Oligonucleotide Labelling and Cyclisation
Authors: Su Meng , Wang Jie , Tang XinJing 
Published: July 2012

AbstractWe have used a photocaging strategy to develop novel phosphoramidites and expand the repertoire of protecting groups for modification of oligonucleotides by solid‐phase synthesis. We synthesised five photolabile phosphoramidites and four new photolabile controlled pore glasses (CPGs). By using these photolabile phosphoramidites and CPGs, modified oligodeoxynucleotides (ODNs) with phosphate, amine, acid, thiol and carbonyl moieties at 5′ and/or 3′ ends were readily synthesised. To the best of our knowledge, this is the first report of introducing a carbonyl at the 5′ end and thiol groups at both ends of ODNs with photolabile modifiers. Terminal labelling was also easily realised in solution or by on‐column solid‐phase synthesis. By using the photolabile amine modifier and the photolabile acid CPG, cyclisation of an oligodeoxynucleotide was achieved with good yields. This study provides an alternative way to introduce functional groups into oligonucleotides and expand the scope of oligonucleotide bio‐orthogonal labelling.
Structure–Activity Studies on the Fluorescent Indicator in a Displacement Assay for the Screening of Small Molecules Binding to RNA
Authors: Umemoto Shiori , Im Seongwang , Zhang Jinhua , Hagihara Masaki , Murata Asako , Harada Yasue , Fukuzumi Takeo , Wazaki Takahiro , Sasaoka Shin‐ichi , Nakatani Kazuhiko 
Published: July 2012

AbstractA series of xanthone and thioxanthone derivatives with aminoalkoxy substituents were synthesized as fluorescent indicators for a displacement assay in the study of small‐molecule–RNA interactions. The RNA‐binding properties of these molecules were investigated in terms of the improved binding selectivity to the loop region in the RNA secondary structure relative to 2,7‐bis(2‐aminoethoxy)xanthone (X2S) by fluorimetric titration and displacement assay. An 11‐mer double‐stranded RNA and a hairpin RNA mimicking the stem loop IIB of Rev response element (RRE) RNA of HIV‐1 mRNA were used. The X2S derivatives with longer aminoalkyl substituents showed a higher affinity to the double‐stranded RNA than the parent molecule. Introduction of a methyl group on the aminoethoxy moiety of X2S effectively modulated the selectivity to the RNA secondary structure. Methyl group substitution at the C1′ position suppressed the binding to the loop regions. Substitution with two methyl groups on the amino nitrogen atom resulted in reducing the affinity to the double‐stranded region by a factor of 40 %. The effect of methyl substitution on the amino nitrogen atom was also observed for a thioxanthone derivative. Titration experiments, however, suggested that thioxanthone derivatives showed a more prominent tendency of multiple binding to RNA than xanthone derivatives. The selectivity index calculated from the affinity to the double‐stranded and loop regions suggested that the N,N‐dimethyl derivative of X2S would be suitable for the screening of small molecules binding to RRE.
Rapid and Efficient Access to Secondary Arylmethylamines
Authors: Fleury‐Brégeot Nicolas , Raushel Jessica , Sandrock Deidre L. , Dreher Spencer D. , Molander Gary A. 
Published: July 2012

AbstractAmmoniomethyl trifluoroborates are very powerful reagents that can be used to access biologically relevant aryl‐ and heteroaryl‐methylamine motifs via Suzuki–Miyaura cross‐couplings. Until now, this method was limited to the production of tertiary and primary amines. The synthesis of a large array of secondary ammoniomethyltrifluoroborates has been achieved through a one step nucleophilic substitution reaction on the potassium bromomethyltrifluoroborate. Smooth cross‐coupling conditions have been designed, based on the use of an aminobiphenyl palladium precatalyst, to couple these trifluoroborates efficiently with aryl bromides. This strategy offers a new way to access biologically relevant motifs and allows, with the previously developed methods, access to all three classes of aminomethylarenes.
Mechanism of the Cycloaddition of Carbon Dioxide and Epoxides Catalyzed by Cobalt‐Substituted 12‐Tungstenphosphate
Authors: Chen Fawang , Li Xiaofang , Wang Bo , Xu Tiegang , Chen Shi‐Lu , Liu Peng , Hu Changwen 
Published: July 2012

AbstractCoII‐substituted α‐Keggin‐type 12‐tungstenphosphate [(n‐ C4H9)4N]4H[PW11Co(H2O)O39]‐ (PW11Co) is synthesized and used as a single‐component, solvent‐free catalyst in the cycloaddition reaction of CO2 and epoxides to form cyclic carbonates. The mechanism of the cycloaddition reaction is investigated using DFT calculations, which provides the first computational study of the catalytic cycle of polyoxometalate‐catalyzed CO2 coupling reactions. The reaction occurs through a single‐electron transfer from the doublet CoII catalyst to the epoxide and forms a doublet CoIII–carbon radical intermediate. Subsequent CO2 addition forms the cyclic carbonate product. The existence of radical intermediates is supported by free‐radical termination experiments. Finally, it is exhilarating to observe that the calculated overall reaction barrier (30.5 kcal mol−1) is in good agreement with the real reaction rate (83 h−1) determined in the present experiments (at 150 °C).
Borophosphonate Cages: Easily Accessible and Constitutionally Dynamic Heterocubane Scaffolds
Authors: Tönnemann Justus , Scopelliti Rosario , Zhurov Konstantin O. , Menin Laure , Dehnen Stefanie , Severin Kay 
Published: July 2012

AbstractA versatile and experimentally facile procedure for the synthesis of borophosphonate cages of the general formula [tBuPO3BR′]4 is described. The method involves heating of tert‐butylphosphonic acid with a boronic acid in toluene to give borophosphonates in [4+4] condensation reactions. The products display a heterocubane structure with bent P‐O‐B bridges as evidenced by crystallographic analyses. Scrambling experiments show that the borophosphonate cages are constitutionally dynamic scaffolds with exchange reactions occurring on the hour time scale at room temperature. The cages can be decorated with reactive groups such as aldehydes. Our results demonstrate that borophosphonate cages are interesting building blocks for dynamic covalent chemistry.
ChemInform Abstract: Influence of Structural Distortions upon Photoluminescence Properties of Eu3+ and Tb3+ Activated Na3Ln(BO3)2 (Ln: Y, Gd) Borates.
Authors: Naidu S. Asiri , Boudin S. , Varadaraju U. V. , Raveau B. 
Published: July 2012

AbstractEu3+ and Tb3+ activated Na3Gd(BO3)2 exhibits higher photoluminescence emission intensities than Eu3+ and Tb3+ activated Na3Y(BO3)2 The better performance for Na3Gd(BO3)2 is due to less regular environment of Eu3+ (Tb3+) at the Gd sites than at the Y sites of Na3Y(BO3)2.
ChemInform Abstract: The T2 Phase in the Nb—Si—B System Studied by ab initio Calculations and Synchrotron X‐Ray Diffraction.
Authors: Joubert J.‐M. , Colinet C. , Rodrigues G. , Suzuki P.A. , Nunes C. A. , Coelho G. C. , Tedenac J.‐C. 
Published: July 2012

AbstractThe compounds Nb0.62Si0.38, Nb0.64Si0.30B0.06, Nb0.64Si0.24B0.12, Nb0.64Si0.18B0.18, and Nb0.64Si0.14B0.22 belonging to the solid solution based on Nb5Si3 in the Nb—Si—B system are characterized by synchrotron powder XRD and DFT calculations.
ChemInform Abstract: Chiral Silver Phosphate‐Catalyzed Cycloisomeric Kinetic Resolution of α‐Allenic Alcohols.
Authors: Wang Yan , Zheng Kuan , Hong Ran 
Published: July 2012

AbstractThe title method affords both enantiomerically enriched α‐allenic alcohols and 2,5‐dihydrofurans from a variety of racemic aryl‐, alkyl‐, and alkenyl‐substituted allenic alcohols.
ChemInform Abstract: (Z)‐Selective Copper‐Catalyzed Asymmetric Allylic Alkylation with Grignard Reagents.
Authors: Giannerini Massimo , Fananas‐Mastral Martin , Feringa Ben L. 
Published: July 2012

AbstractAllylic gem‐dichlorides undergo the regio‐ and enantioselective title reaction to give chiral (Z)‐vinyl chlorides.
ChemInform Abstract: Investigation of the Catalytic Activity of Poly(4‐vinylpyridine) Supported Iodine as a New, Efficient and Recoverable Catalyst for Regioselective Ring Opening of Epoxides.
Authors: Khalig Nader Ghaffari 
Published: July 2012

AbstractRing opening of epoxides works with high regioselectivity in alcohols, water and acetic acid.
ChemInform Abstract: Lacunary Derivative [HPW9O34]8‐ as Reusable and Active Catalyst for Alcohol Oxidation in Water.
Authors: Zhao Wei , Ding Yong , Ma Baochun , Qiu Wenyuan 
Published: July 2012

AbstractAn environmentally friendly and efficient procedure for the selective oxidation of secondary alcohols to corresponding ketones is developed.
ChemInform Abstract: Silver‐Catalyzed Decarboxylative Chlorination of Aliphatic Carboxylic Acids.
Authors: Wang Zhentao , Zhu Lin , Yin Feng , Su Zhongquan , Li Zhaodong , Li Chaozhong 
Published: July 2012

AbstractUnder catalysis of Ag(phen)2OTf, primary, secondary and tertiary aliphatic carboxylic acids are decarboxylated and chlorinated by tBuOCl.
ChemInform Abstract: Direct Bifunctional Squaramide‐Catalyzed Asymmetric N‐Nitroso Aldol Reaction of Tertiary β‐Carbonyl Esters.
Authors: Yang Hong‐Jun , Dai Le , Yang Shi‐Qiong , Chen Fen‐Er 
Published: July 2012

AbstractEnantioselective α‐hydroxyamination of β‐carbonyl esters and ketones is achieved by reaction with nitrosobenzene in the presence of SQA.
ChemInform Abstract: Nano Rod‐Shaped and Reusable Basic Al2O3 Catalyst for N‐Formylation of Amines under Solvent‐Free Conditions: A Novel, Practical and Convenient “NOSE” Approach.
Authors: Das Vijay Kumar , Devi Rashmi Rekha , Raul Prasanta Kumar , Thakur Ashim Jyoti 
Published: July 2012

AbstractA simple and efficient method is elaborated for the formylation of primary and secondary amines (I) and (X), diamines (VI), and some 5‐membered N‐heterocycles such as (XII) and (XIV).
ChemInform Abstract: Rapid Formation of Diphenylmethyl Ethers and Thioethers Using Microwave Irradiation and Protic Ionic Liquids.
Authors: Henderson Luke C. , et al. et al. 
Published: July 2012

AbstractA combination of microwaves and protic ionic liquids, prepared prior to use by carefully mixing equimolar amounts of triethylamine and an acid under controlled conditions, allows the efficient protection of alcohols or thiols with the diphenyl methyl group.
ChemInform Abstract: Indium(III) Chloride Catalyzed Conjugate Addition Reaction of Alkynylsilanes to Acrylate Esters.
Authors: Xu Yan‐li , Pan Ying‐ming , Liu Pei , Wang Heng‐shan , Tian Xiao‐yan , Su Gui‐fa 
Published: July 2012

AbstractThe reaction allows a new and efficient access to a number of γ,δ‐alkynyl esters.
ChemInform Abstract: N,N,N′,N′‐Tetramethylmethanediamine, Efficient Reagent for Thioles Aminomethylation.
Authors: Khairullina R. R. , Akmanov B. F. , Tyumkina T. V. , Kunakova R. V. , Ibragimov A. G. 
Published: July 2012

AbstractApplying tetramethylmethanediamine (I) in a new approach to aminomethylation of mono‐ and dithiols (II) and (IV) in the presence of samarium and iron salts affords the aminosulfides (III) and diaminodisulfides (V) with high yields and selectivity.
ChemInform Abstract: N‐Heterocyclic Carbene Catalyzed Homoenolate Addition to 3‐Methyl‐4‐nitro‐5‐styrylisoxazoles.
Authors: Illera Diana Salazar , Suresh Surisetti , Moccia Maria , Bellini Gea , Saviano Michele , Adamo Mauro F. A. 
Published: July 2012

AbstractThe title reaction yields functionalized cyclopentanones (III) as single diastereomers.
ChemInform Abstract: Synthesis of Phloroglucinol Monoaryl Ethers.
Authors: Sherwood Alexander M. , Pond David M. , Trudell Mark L. 
Published: July 2012

AbstractCondensation of 3,5‐dimethoxyphenol with activated fluorobenzenes and subsequent demethylation provides an efficient and scalable method for the preparation of the desired structures (IV) as analogues of the cannabinoid partial agonist BAY59‐3074 (V).
ChemInform Abstract: Dehydrogenative Oxidation of Alcohols in Aqueous Media Using Water‐Soluble and Reusable Cp*Ir Catalysts Bearing a Functional Bipyridine Ligand.
Authors: Kawahara Ryoko , Fujita Ken‐ichi , Yamaguchi Ryohei 
Published: July 2012

AbstractA newly designed catalyst, which is applied to the first example of the title reaction in aqueous media, can be efficiently reused not only for oxidation of the same substrate but also for oxidation of different substrates.
ChemInform Abstract: Regioselectivity Switch Achieved in the Palladium‐Catalyzed α‐Arylation of Enones by Employing the Modified Kuwajima—Urabe Conditions.
Authors: Kale Ajit Prabhakar , Pawar Govind Goroba , Kapur Manmohan 
Published: July 2012

AbstractA modified protocol allows the synthesis of α‐aryl enones with high regioselectivity by arylation of triethylsilylenol ethers of enones with aryl bromides or triflates in the presence of sterically encumbered phosphine ligands.
ChemInform Abstract: μ‐Oxo‐Bridged Hypervalent Iodine(III) Compound as an Extreme Oxidant for Aqueous Oxidations.
Authors: Dohi Toshifumi , Nakae Tomofumi , Takenaga Naoko , Uchiyama Teruyoshi , Fukushima Kei‐ichiro , Fujioka Hiromichi , Kita Yasuyuki 
Published: July 2012

AbstractPIT is generally more reactive than the monomeric analogue, especially towards phenols.
ChemInform Abstract: Metal or Ammonium Alginates as Lewis Base Catalysts for the 1,2‐Addition of Silyl Nucleophiles to Carbonyl Compounds.
Authors: Verrier Cecile , Oudeyer Sylvain , Dez Isabelle , Levacher Vincent 
Published: July 2012

AbstractThe first investigation of ammonium or metal alginates reveals that TBA is the most efficient catalyst.
ChemInform Abstract: Synthesis of a Wide Range of Thioesters by Indium Triiodide Catalyzed Direct Coupling Between Alkyl Acetates and Thiosilanes.
Authors: Nishimoto Yoshihiro , Okita Aya , Yasuda Makoto , Baba Akio 
Published: July 2012

AbstractThe method is highly selective for the acetate moiety as is shown by formation of main product (XVII).
ChemInform Abstract: Electrophilic Substitution Reactions Using an Electrogenerated ArS(ArSSAr)+ Cation Pool as an ArS+ Equivalent.
Authors: Matsumoto Kouichi , Kozuki Yuki , Ashikari Yosuke , Suga Seiji , Kashimura Shigenori , Yoshida Jun‐ichi 
Published: July 2012

AbstractThe sulfonium ion is generated in situ by low temperature electrolysis of disulfide (I).
ChemInform Abstract: Use of Dimethyl Carbonate as a Solvent Greatly Enhances the Biaryl Coupling of Aryl Iodides and Organoboron Reagents without Adding any Transition Metal Catalysts.
Authors: Inamoto Kiyofumi , Hasegawa Chisa , Hiroya Kou , Kondo Yoshinori , Osako Takao , Uozumi Yasuhiro , Doi Takayuki 
Published: July 2012

AbstractA new approach to prepare biaryls (III).
ChemInform Abstract: Efficient Anodic and Direct Phenol‐Arene C,C Cross‐Coupling: The Benign Role of Water or Methanol.
Authors: Kirste Axel , Elsler Bernd , Schnakenburg Gregor , Waldvogel Siegfried R. 
Published: July 2012

AbstractFor the first time a significantly improved electrochemical C‐C cross‐coupling is reported.
ChemInform Abstract: Solvent‐Controlled Selective Transformation of 2‐Bromomethyl‐2‐methylaziridines to Functionalized Aziridines and Azetidines.
Authors: Stankovic Sonja , Goossens Hannelore , Catak Saron , Tezcan Meniz , Waroquier Michel , Van Speybroeck Veronique , D'hooghe Matthias , De Kimpe Norbert 
Published: July 2012

AbstractHeating of substrates (I) in MeCN allows efficient access to azetidines such as (III) and (V).
ChemInform Abstract: BINAPHANE‐Catalyzed Asymmetric Synthesis of trans‐β‐Lactams from Disubstituted Ketenes and N‐Tosyl Arylimines.
Authors: Chen Shi , Salo Eric C. , Wheeler Kraig A. , Kerrigan Nessan J. 
Published: July 2012

AbstractThe title reaction under conditions A) affords the desired key structures with high trans‐selectivity and even dialkylketenes are tolerated as substrates.
ChemInform Abstract: Asymmetric Synthesis of O‐Alkylated Tetronic Acid Derivatives via an Organocatalytic Mannich Reaction and Subsequent Intramolecular Cyclization.
Authors: Luo Nian‐hua , Sun Xiang , Yan Yun‐yun , Nie Shao‐zhen , Yan Ming 
Published: July 2012

AbstractChiral thiourea‐tertiary amine THU is identified as the best catalyst for the Mannich reaction of β‐ketoester (I) with N‐Boc‐imines.
ChemInform Abstract: A Practical Preparation of Highly Versatile N‐Acylpyrroles from 2,4,4‐Trimethoxybutan‐1‐amine.
Authors: Maehara Tomoaki , Kanno Rentaro , Yokoshima Satoshi , Fukuyama Tohru 
Published: July 2012

AbstractCondensation of (I) with carboxylic acids is followed by acid‐promoted cyclization of the amide intermediates.
ChemInform Abstract: Regioselective Synthesis of Trifluoromethylated 3‐(Pyrazolyl)indoles on the Basis of 6‐(Trifluoromethyl)comanic Acid.
Authors: Usachev Boris I. , Obydennov Dmitrii L. , Sosnovskikh Vyacheslav Ya. 
Published: July 2012

AbstractThe synthesis of trifluoromethylated indoles (IV) and (VI) starts with the regioselective recyclization of (trifluoromethyl)comanic acid derivatives (I) in the presence of phenylhydrazine (II) in dependance of solvent polarity to give either compounds (III) or (V), respectively.
ChemInform Abstract: Dioxindole in Asymmetric Catalytic Synthesis: Direct Access to 3‐Substituted 3‐Hydroxy‐2‐oxindoles via 1,4‐Additions to Nitroalkenes.
Authors: Retini Michele , Bergonzini Giulia , Melchiorre Paolo 
Published: July 2012

AbstractA bifunctional primary amine—thiourea catalyst for the asymmetric Michael addition of dioxindoles to β‐substituted nitroalkenes is presented.
ChemInform Abstract: Domino Reactions in Water: Diastereoselective Synthesis of Densely Functionalized Indolyldihydrofuran Derivatives.
Authors: Gunasekaran Pethaiah , Balamurugan Kamaraj , Sivakumar Sathiyamoorthi , Perumal Subbu , Menendez J. Carlos , Almansour Abdulrahman I. 
Published: July 2012

AbstractA series of trans‐dihydrofuran derivatives (III) (26 examples) is readily prepared by a triethylamine‐catalyzed domino reaction of chalcones (I) with bromides (II) in aqueous media.
ChemInform Abstract: Addition of Indoles to Oxyallyl Cations for Facile Access to α‐Indole Carbonyl Compounds.
Authors: Tang Qiang , Chen Xingkuan , Tiwari Bhoopendra , Chi Yonggui Robin 
Published: July 2012

AbstractPractical conditions are developed for the direct coupling of a variety of α‐halo ketones with indoles at C‐3.
ChemInform Abstract: Syntheses of 2‐(Trifluoromethyl)‐1,3‐dicarbonyl Compounds Through Direct Trifluoromethylation with CF3I and Their Application to Fluorinated Pyrazoles Syntheses.
Authors: Ohtsuka Yuhki , Uraguchi Daisuke , Yamamoto Kyoko , Tokuhisa Kenji , Yamakawa Tetsu 
Published: July 2012

AbstractDimethyl and diethyl malonate, which only exist in the keto‐form, do not afford trifluoromethylated products at all.
ChemInform Abstract: Copper‐Catalyzed One‐Pot Synthesis of Tetrasubstituted Pyrazoles from Sulfonyl Azides, Terminal Alkynes, and Hydrazonoyl Chlorides.
Authors: Yavari Issa , Nematpour Manijeh , Yavari Sima , Sadeghizadeh Fatemeh 
Published: July 2012

AbstractAddition of copper acetylides to sulfonyl azides generates ketenimine intermediates which are readily trapped by nitrile imines to give pyrazole structures which are suitable for further manipulations.
ChemInform Abstract: Synthesis of Imidazo[4,5‐b]pyridines and Imidazo[4,5‐b]pyrazines by Palladium‐ Catalyzed Amidation of 2‐Chloro‐3‐aminoheterocycles.
Authors: Rosenberg Adam J. , Zhao Jinbo , Clark Daniel A. 
Published: July 2012

AbstractThe process allows a quick access to various natural products and biologically interesting title compounds with substituents at N‐1 and C‐2.
ChemInform Abstract: A Facile Synthesis of Novel 3‐(Aryl/Alkyl‐2‐ylmethyl)‐2‐thioxothiazolidin‐4‐ones Using Microwave Heating.
Authors: Kamila Sukanta , Ankati Haribabu , Harry Emily , Biehl Edward R. 
Published: July 2012

AbstractThe procedure affords the title compounds (23 examples) in high yields and a short reaction time.
ChemInform Abstract: A One‐Pot Synthesis of [1,3,4]‐Oxadiazoles Mediated by Molecular Iodine.
Authors: Guin Srimanta , Rout Saroj Kumar , Ghosh Tuhin , Khatun Nilufa , Patel Bhisma K. 
Published: July 2012

AbstractThiosemicarbazides (I) and (III), generated in situ from dithiocarbamate salts and formic hydrazide and benzhydrazide, are converted into oxadiazoles (II) and (IV) by cyclodesulfurization with molecular iodine.
ChemInform Abstract: Antitumor Agents. Part 292. Design, Synthesis and Pharmacological Study of S‐ and O‐Substituted 7‐Mercapto‐ or Hydroxy‐Coumarins and Chromones as Potent Cytotoxic Agents.
Authors: Xia Peng , et al. et al. 
Published: July 2012

AbstractA series of novel coumarin and chromone derivatives is designed, synthesized, and evaluated in vitro for cytotoxic activity against 4 human tumor cell lines.
ChemInform Abstract: Synthesis of Chromeno[3,4‐b]indoles as Lamellarin D Analogues: A Novel DYRK1A Inhibitor Class.
Authors: Routier Sylvain , et al. et al. 
Published: July 2012

AbstractA library of substituted chromeno[3,4‐b]indoles (IX) is developed as lamellarin isosters.
ChemInform Abstract: Copper‐Catalyzed Asymmetric 1,4‐Addition of Alkenyl Alanes to N‐Substituted‐2‐3‐dehydro‐4‐piperidones.
Authors: Mueller Daniel , Alexakis Alexandre 
Published: July 2012

AbstractThe Cbz protecting group is found to be most suitable for the starting substrate which is successfully treated with various aluminum organyls in the presence of the phosphine—amine ligand PAM.