bluuebunny/crossref_metadata_2025_split huggingface dataset:
EU-verfassungs- und wettbewerbsrechtlicher Rahmen der Regulierung digitaler Geschäftsmodelle
Authors: Müller Thomas 
Published: February 2025

Zusammenfassung
Der vorliegende Beitrag nimmt den EU-verfassungs- und wettbewerbsrechtlichen Rahmen für digitale Geschäftsmodelle, insb. in Bezug auf die aktuelle Regulierung von Kryptowerten (Web 3), digitalen Märkten (DMA) und digitalen Zentralbankwährungen in den Blick. Maßstab der Analyse sind die kompetenzrechtlichen, grundrechtlichen und wettbewerbsrechtlichen Vorgaben des EU-Primärrechts. Der Beitrag kommt zu dem Ergebnis, dass einerseits der verfassungsrechtliche Rahmen gut dazu geeignet ist, die regulatorischen Herausforderungen digitaler Geschäftsmodelle auf europäischer Ebene zu bewältigen und eine übermäßige Regulierung oder Ungleichbehandlungen zwischen neuen und alten (digitalen) Geschäftsmodellen zu verhindern. Andererseits erscheinen die aktuellen Regulierungsbestrebungen selbst weitgehend im Einklang mit den primärrechtlichen Rahmenbedingungen zu stehen.
Extending certified spectral fluorescence standards for the calibration and performance validation of fluorescence instruments to the NIR—closing the gap from 750 to 940 nm with two novel NIR dyes
Authors: Richter M. , Güttler A. , Pauli J. , Vogel K. , Homann C. , Würth C. , Resch-Genger U. 
Published: February 2025

Abstract
Fluorescence techniques such as fluorescence spectroscopy, microfluorometry, and fluorescence microscopy, providing spectral, intensity, polarization, and lifetime information, are amongst the most broadly utilized analytical methods in the life and materials sciences. However, the measured fluorescence data contain sample- and instrument-specific contributions, which hamper their comparability across instruments and laboratories. Comparable, instrument-independent fluorescence data require the determination of the fluorescence instrument’s wavelength-dependent spectral responsivity, also termed emission correction curve, for the same instrument settings as those used for the fluorescence measurements as a prerequisite for the subsequent correction of the measured instrument-specific data. Such a spectral correction is essential for the performance comparison of different fluorescent labels and reporters, quantitative fluorescence measurements, the determination of the fluorescence quantum yield, and the spectroscopic measure for the fluorescence efficiency of a fluorophore. Simple-to-use tools for obtaining emission correction curves are chromophore-based reference materials (RMs), referred to as fluorescence standards, with precisely known, preferably certified instrument-independent fluorescence spectra. However, for the increasingly used near-infrared (NIR) wavelength region >700 nm, at present, no spectral fluorescence standards are available. To close this gap, we developed two novel spectral fluorescence standards, BAM F007 and BAM-F009, with broad emission bands from about 580 to 940 nm in ethanolic solution. These liquid fluorescence standards currently under certification, which will be released in 2025, will expand the wavelength range of the already available certified Calibration Kit BAM F001b-F005b from about 300–730 to 940 nm. In this research article, we will detail the criteria utilized for dye and matrix selection and the homogeneity and stability tests accompanying dye certification as well as the calculation of the wavelength-dependent uncertainty budgets of the emission spectra BAM F007 and BAM-F009, determined with the traceably calibrated BAM reference spectrofluorometer. These fluorescence standards can provide the basis for comparable fluorescence measurements in the ultraviolet, visible, and NIR for the fluorescence community.
Changes in Non-invasive Myocardial Stroke Work Related to Variation in Pacing Sites and Heart Rates in Adolescents
Authors: Baskar Shankar , Ta Hieu T. , Spar David S. , Czosek Richard J. , Ollberding Nicholas J. , Tretter Justin T. 
Published: February 2025

Abstract
Non-invasive assessment of myocardial work is a newly described technique to assess myocardial energetics. This has not been previously studied to assess the effects of right ventricular pacing at different sites or at different heart rates in children. We aimed to study the effects of right ventricular apical, septal, and His bundle pacing on myocardial work along with the effects of increasing heart rate. This was a prospective pilot study performed on six patients with structurally normal hearts and function following an electrophysiology study. Global work index and global work efficiency was highest during His pacing and lowest during right ventricular apical pacing. The global constructive work, index, and efficiency were progressively worse with increasing heart rates. In this prospective pilot study, we demonstrated that myocardial work indices differ depending on myocardial activation pattern and at different heart rates in pediatric patients. Myocardial performance as assessed by myocardial work efficiency is worse when pacing is performed at the right ventricular apex when compared to His and right ventricular septal pacing. Myocardial performance can be affected by higher heart rates, following a work–frequency relationship.
The role of PSMA-based radioligand therapy in hormone-sensitive prostate cancer
Authors: Laudicella Riccardo , Bauckneht Matteo , Burger Irene A , Cacciola Alberto , Fanti Stefano , Farolfi Andrea , Ficarra Vincenzo , Iagaru Andrei , Liberini Virginia , Pergolizzi Stefano , Santo Giulia , Virgolini Irene , Minutoli Fabio , Baldari Sergio 
Published: February 2025

Abstract

Purpose
Conventional systemic therapies are valuable options in prostate cancer (PCa); however, such treatments can determine adverse events and toxicity. The observed improvement in overall survival, coupled with PSA reduction and a favorable safety profile in the post-taxane castration-resistant PCa (CRPC) setting has prompted the consideration of PSMA-based radioligand therapy (RLT) earlier in the treatment sequence. In this review, we will describe the literature and ongoing clinical trials regarding the use of PSMA-based RLT in hormone-sensitive PCa (HSPC) including the neoadjuvant, de-novo/synchronous metastatic, adjuvant, and early BCR settings.

Methods
We performed a systematic literature search on the PubMed/MEDLINE/EMBASE and clinicaltrials.gov databases for studies and protocols assessing the role of PSMA-based RLT in HSPC.

Results
The literature search yielded 140 results. After screening titles and abstracts and applying inclusion and exclusion criteria, we selected 25 papers showing the potentialities of earlier RLT in HSPC, with several ongoing trials.

Conclusion
Early use of PSMA-based RLT holds significant potential in HSPC patients from the neoadjuvant to the BCR setting. In these stages, the lower tumor burden, more frequent exclusive nodal involvement, and higher organ reserve may improve treatment efficacy and allow for treatment combinations while maintaining a less toxic profile.
The Effect of the Maxillary Sinus Volume on the Morphology and Angulation of the Infraorbital Canal in Relation to Age and Gender
Authors: Açar Gülay , Gökşan Ahmet Safa , Magat Guldane 
Published: February 2025

Abstract

Background
Although the infraorbital canal (IOC) and maxillary sinus (MS) have been well studied, understanding the effect of MS volume (MSV) on IOC morphology is critical in determining the safest surgical route for infraorbital depression and transmaxillary procedures.

Objectives
We aimed to describe the IOC types, measure the MSV and IOC angles (IOCA) in all three planes, and analyse the relationship between them using three-dimensional (3D) cone beam computed tomography (CBCT) images.

Methods
CBCT images of 280 patients were analysed to identify the IOC types and accessory IOC (IOCa), and to measure morphometric parameters. The relationship between them was examined using statistical analysis in relation to age, gender, and laterality.

Results
The most common IOC type was Type I (59.6%), followed by Type II (21.8%), Type III (13.6%), and Type IV (5%). According to MSV, three types of MS were described, with 38.2, 34.6, and 27.2% having normal, hypoplastic, and hyperplastic MS, respectively. Also, hyperplastic MS was associated with the highest likelihood of Type III IOC. Furthermore, logistic regression model revealed that the MSV and IOCA3 had a positive significant effect on the IOC protrusion, whereas being female, increasing age and IOCA1 had a negative significant effect on MS pneumatization. The probability of having hyperplastic MS, Types II and III IOC, IOCa also decreased with increasing age.

Conclusions
Using 3D technology, the results of this study provide a detailed classification of IOC and MS types, increasing the number of treatment options and reducing the risk of complications during surgery.

Level of Evidence IV
This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266.
Clinical importance of incisional hernia in patients resected for colorectal liver metastases: quality of life and abdominal wall symptoms
Authors: Holka Peter Strandberg , Lindell Gert , Tingstedt Bobby , Sturesson Christian 
Published: February 2025

Abstract

Purpose
Incisional hernia (IH) after open liver surgery is a well-recognized complication. The clinical importance of IH detected on computed tomography in terms of objective abdominal wall discomfort and impairment of quality of life (QoL) is less well known.

Methods
Patients who underwent curative surgery for colorectal liver metastases between 2010 and 2015 at a single center and were alive in February 2017 were asked to complete a ventral hernia pain questionnaire and the EORTC QLQ-C30 QoL questionnaire.

Results
A total of 105 patients (80%) completed the questionnaires. Forty-three patients (42%) developed IH. The majority (77%) of IHs were < 2.5 cm. Patients who had an IH before liver surgery developed a new IH to a greater extent (P = 0.001). There were no significant differences regarding abdominal wall symptoms and QoL between patients with and without IH. However, about half (48%) of all patients had abdominal wall symptoms after a median follow-up of 34 months.

Conclusion
Radiologically detected IH after open liver surgery has low clinical importance. About half of all patients who underwent liver surgery experienced abdominal wall symptoms a long after surgery, but these symptoms were not related to IH.
Early assessment of clinical complexity and home care in patients affected by trisomy 13 and 18
Authors: Zanin Anna , Patti Matteo , Rosato Isabella , Divisic Antuan , Rusalen Francesca , Maghini Irene , Agosto Caterina , Benini Franca 
Published: February 2025

Abstract

Purpose
Trisomy 13 and 18 consist of a recurrent pattern of multiple congenital anomalies. The aim of this study was to analyze the clinical characteristics and disease trajectory of a cohort of children with trisomy 13 and 18 followed up by an Italian pediatric palliative care service.

Methods
A single-center retrospective observational study was conducted examining the medical records of patients with trisomy 13 and 18 seen in the Pediatric Palliatives Care (PPC) center of the University Hospital of Padua from 2007 to 2022.

Results
Seventeen patients were included in the analysis. All were born alive; four children are still alive and only three (23%) died at home. All presented high care complexity, as estimated by ACCAPED index (median 86, range 38–129). The median time to receive care from PPC was 3 months (0–108). All patients’ parents shared an advance care plan with the PPC team: 13/17 patients (76%) accepted a do not resuscitate (DNR) order. Approximately 12% of patients received at least one surgery. The trend of survival compared with other cohorts reported in the literature does not appear to differ significantly after the initial stages.

Conclusions
The possible recognition of an early evolution toward medical complexity and the availability of home care resources and programs are crucial factors in the management of these children. These indices could become a driving factor in the definition of new outcomes that are more patient-oriented, in addition to mortality.

What is known:
• Trisomy 13 and 18 are serious genetic conditions with high mortality rates. In the last years medical interventions including surgery are being offered more frequently, though the appropriateness of these interventions is still debated.
What is new:
• The study emphasizes the crucial role of early referral to specialized pediatric palliative care teams and the coordination they provide enabling families to care for their children at home, even with complex medical needs.
Survivorship care plan utilization in Australia and New Zealand: survivors’, parents’ and healthcare providers’ perspectives
Authors: Hill Rebecca E. , Fardell Joanna E. , Mercieca-Bebber Rebecca , Wakefield Claire E. , Signorelli Christina , Webber Kate , Johnston Karen A. , Cohn Richard J. 
Published: February 2025

Abstract

Purpose
As part of survivorship care, many health authorities recommend survivorship care plans (SCPs). The aim of this study was to understand survivors’ SCP receipt and use, clinical/demographic factors associated with use, and providers’ SCP practices.

Methods
We surveyed Australian and New Zealand survivors of adult and childhood cancer (including parent proxies for survivors aged < 16 years). We fitted binomial logistic regression models to examine the relationship between survivors’ clinical and sociodemographic characteristics, and SCP receipt. We also surveyed oncology health providers regarding current SCP provision practices, perceived receipt, and usefulness.

Results
We recruited 1123 cancer survivors (499 adult cancer survivors and 624 childhood cancer survivors, including 222 parent proxies) and 21 healthcare providers. 10.7% of adult and 22.0% of childhood cancer survivors recalled receiving SCPs. SCP receipt was more likely for adult cancer survivors diagnosed with prostate cancer, low-risk cancer diagnoses and older at study participation, and childhood cancer survivors treated with chemotherapy or younger at study participation. Across both groups, a higher level of education attainment was predictive of SCP use. Most healthcare providers estimated that < 15% of adult and > 75% of childhood cancer survivors received SCPs.

Conclusions
Few survivors of adult or childhood cancer reported receiving a SCP, and there were sociodemographic and clinical differences in those who did and did not receive and use their SCP. SCP recipients used and valued them, but healthcare providers indicated potential areas for improvement with SCP provision. Consideration may be needed regarding SCP format, presentation and content.
Central venous access device management for children undergoing treatment for blood disorders and cancer: a descriptive international cross-sectional survey
Authors: Hyun Areum , Takashima Mari D. , de Souza Sabrina , Gibson Victoria , Silva Thiago Lopes , Rocha Patricia Kuerten , Vetcho Siriporn , Ullman Amanda J. 
Published: February 2025

Abstract

Purpose
This study aimed to explore current central vascular access device (CVAD) management practices in pediatric cancer care globally and compare practices across high-income and middle-income (i.e., upper middle-income and lower middle-income) countries.

Methods
A descriptive cross-sectional international survey was conducted between May 2022 and December 2023. Clinicians involved in CVAD insertion/management for pediatric cancer patients were invited to participate through established clinical networks globally. The survey covered CVAD management practices, including dressings, securements, routine care, and maintenance procedures.

Results
A total of 220 responses from 42 countries were received. Polyurethane dressings were most commonly used across all CVAD types (55–65/34.2–40.4). Bordered dressings were the primary securement method for all CVAD types (69–96/161, 42.9–59.6%). Routine practices varied, with 31/102 (30.4%) assessing CVADs hourly during infusion in high-income countries and 22 (37.3%) assessing every shift in middle-income countries. Heparin and normal saline were the commonly used solutions for flushing and locking. Chlorhexidine 2% in 70% alcohol was the predominant decontamination solution in high-income countries (64/102, 62.8%), while alcohol was more common in middle-income countries (22/59, 37.3%). Differences were observed between high-income and middle-income countries in the types of dressings, securements, and maintenance practices used.

Conclusion
This study revealed significant variability in CVAD management practices for pediatric cancer care globally, particularly between high-income and middle-income countries. These findings highlight the need for standardized, evidence-based guidelines considering resource availability and contextual factors to improve CVAD management in pediatric oncology across diverse healthcare settings.
Multiplexed detection of respiratory virus RNA using optical pH sensors and injection-molded centrifugal microfluidics
Authors: Suarez Gianmarco Domenico , Tang Yuki Yu Kiu , Bayer Steevanson , Cheung Peter Pak-Hang , Nagl Stefan 
Published: February 2025

Abstract
The application is demonstrated of injection-molded centrifugal microfluidic chips with integrated optical pH sensors for multiplexed detection of respiratory syndrome coronavirus 2 (SARS-CoV-2), influenza A, and influenza B RNA. The optical pH sensors generated sensitive fluorescent readouts from diagnostic reverse transcription loop-mediated isothermal amplification (RT-LAMP) reactions; limits of detection for influenzas A and B, and SARS-CoV-2 of 89, 245, and 38 RNA copies per reaction, respectively, were attained. Results were obtainable within 44 min for SARS-CoV-2 and influenza A, and 48 min for influenza B. We implemented a data processing strategy based on numerical derivatives of the fluorescence curves that allowed for reliable, quantitative thresholds for deciding reaction outcomes and enabled 100% specificity. This work demonstrates the utility of optical pH sensors and injection-molded centrifugal microfluidics for multiplexed infectious disease diagnostics with point-of-care applications.

Graphical Abstract
Two-stage surgical strategy for extensive craniofacial fibrous dysplasia with cerebral compression
Authors: Pasquini Ludovica , Biswas Chandrima , Zachariah Marcus , Prevedello Daniel M. 
Published: February 2025

Abstract

Background
The management of extensive craniofacial fibrous dysplasia requires balancing the extent of resection with the perioperative morbidity and complications.

Method
The authors describe a case involving the resection of extensive craniofacial fibrous dysplasia performed in two stages. The first surgery aims on removing most of the lesion and planning for bony reconstruction, while the second stage focuses to complete disease removal and implant a custom-made prosthesis.

Conclusion
This case highlights the benefits of a two-stage surgical approach in reducing morbidity compared to a single extensive surgery while achieving excellent disease resection and functional outcomes.
Improve communication of accessibility web barriers with an empathetic perspective to enhance the accessible user experience (AUX)
Authors: Pascual-Almenara Afra , Granollers Saltiveri Toni 
Published: February 2025

Abstract
A prototype is presented featuring accessible and non-accessible web elements, formalized within a dynamic web context. The outcome is a system that empathetically communicates the impact of accessibility barriers on users with disabilities. The system aims to convey messages through the perspective of people with disabilities so that prosumer users—those who produce and consume web content—foster an understanding of the necessity to integrate accessibility features into their web content. This work is an initial proposal about understanding web accessibility guidelines beyond the WCAG documentation, to show non-technical users an understanding of web access barriers from an empathetic perspective and investigates the accessible user experience. It is crucial to note that achieving web accessibility involves not only complying with WCAG guidelines, but also considering various aspects to ensure people with disabilities have an accessible user experience on the web.
Temporal changes in parameters associated with tear film stability after instillation of long-acting diquafosol ophthalmic solution in soft contact lens wearers
Authors: Itokawa Takashi , Suzuki Takashi , Iwashita Hiroko , Okajima Yukinobu , Kakisu Koji , Hori Yuichi 
Published: February 2025

Abstract

Purpose
To investigate temporal changes in parameters associated with tear film stability after instillation of long-acting 3% diquafosol ophthalmic solution (DQS LX), which contains polyvinylpyrrolidone.

Study Design
Prospective crossover study design.

Methods
We enrolled 23 eyes of 23 soft contact lens (SCL) wearers (aged 25.3 ± 4.4 years). One-day disposable silicone hydrogel lenses (narafilcon A) were used in this study. DQS LX was instilled without a SCL on the first day. On the other two days, subjects received DQS or DQS LX at 7 h after wearing SCLs. Tear meniscus height (TMH), non-invasive tear break-up time (NIBUT) and ocular surface temperature (OST) were measured before and at 5, 15, 30, 45, 60, 80 and 120 min after instillation.

Results
When not wearing SCLs, DQS LX instillation significantly improved TMH for up to 120 min and NIBUT for up to 80 min. When wearing SCLs, DQS and DQS LX instillation significantly increased TMH for up to 45 and 80 min, and NIBUT for up to 15 and 30 min. Compared to DQS, DQS LX administration resulted in a significantly higher TMH at 5, 60 and 80 min, as well as a significantly prolonged NIBUT at 5 and 60 min. OST with and without SCLs also varied depending on the changes in the parameters associated with tear film stability.

Conclusion
Compared to DQS, when wearing SCLs, DQS LX was found to increase the amount of tear fluid and improve tear film stability for longer periods.
Neglected predatory insects trigger potential Key Biodiversity Areas in threatened coastal habitats
Authors: Ascenzi Aleida , Nania Dario , Cristiano Andrea , Badano Davide , Pacifici Michela , Cerretti Pierfilippo 
Published: February 2025

Abstract
Key Biodiversity Areas (KBAs) have the potential to become a powerful tool for identifying regions that host unique biodiversity. With their great diversity, insects hold significant potential as indicators for global KBA mapping, even in highly specialized and narrowly distributed habitats. For instance, species adapted to fragmented ecosystems like coastal sand dunes—among the most heavily impacted habitats worldwide—can serve as critical indicators to trigger KBAs in these fragile environments. Despite their relevance as indicators, the inclusion of insects in KBA assessments remains limited, particularly for less-studied insect groups, whose distribution data is often fragmented and affected by taxonomic uncertainties. We tested selected KBA criteria on 26 antlion and owlfly species (Neuroptera: Myrmeleontidae) in Italy, including dune specialists, and performed a barcode gap analysis based on cytochrome c oxidase subunit 1 mitochondrial marker (COI) to identify potential misidentifications, which could compromise the robustness of KBA assessments. Several endemic and dune specialist species trigger potential KBAs, showing limited (< 20% of their extent) overlap with the current protected area network, confirming the great value of these taxa in narrowly distributed habitats. We advise for the integration of both spatial and genetic data to increase accuracy of potential Key Biodiversity Areas assessments using neglected insect taxa.