bluuebunny/crossref_metadata_2025_split huggingface dataset:
Optimal Timing of Cranioplasty After Decompressive Craniectomy: Timing or Collapse Ratio
Authors: Huo Hongyue , Lu Yizhou , Lu Jun , Wang Xiaolin , Wang Zheng , Jiang Jianxin , Lou Gaojie 
Published: June 2024

BACKGROUND AND OBJECTIVES:
Although cranioplasty (CP) is a relatively straightforward surgical procedure, it is associated with a high complication rate. The optimal timing for this surgery remains undetermined. This study aimed to identify the most suitable timing for CP to minimize postoperative complications.

METHODS:
We conducted a retrospective analysis of all CP cases performed in our department from August 2015 to March 2022. Data were gathered through case statistics and categorized based on the occurrence of complications. The collapse ratio was determined using 3-dimensional Slicer software.

RESULTS:
In our retrospective study of 266 patients, 51 experienced postoperative complications, including hydrocephalus, epidural effusion, subdural hematoma, epilepsy, and subcutaneous infection. Logistic regression analysis identified independent predictors of postcranioplasty complications, and a nomogram was developed. The predictive value of the logistic regression model, collapse ratio, and decompression craniotomy-CP operation interval for post–skull repair complications was assessed using receiver operating characteristic curve analysis. No significant differences were observed in postoperative complications and decompression craniotomy-CP intervals between the groups (P = .07, P > .05). However, significant differences were noted in postoperative collapse ratios and CP complications between the groups (P = .023, P < .05). Logistic regression revealed that the collapse ratio (odds ratio = 1.486; 95% CI: 1.001-2.008; P = .01) and CP operation time (odds ratio = 1.017; 95% CI: 1.008-1.025, P < .001) were independent risk factors for postoperative complications. Receiver operating characteristic curve analysis indicated that the collapse ratio could predict CP postoperative complications, with a cutoff value of 0.274, an area under the curve of 0.621, a sensitivity of 62.75%, and a specificity of 63.26%.

CONCLUSION:
The post–skull repair collapse ratio is a significant predictor of postoperative complications. It is advisable to base the timing of surgery on the extent of brain tissue collapse, rather than solely on the duration between cranial decompression and CP.
Targeting Patient-Derived Orthotopic Gastric Cancers with a Fluorescent Humanized Anti-CEA Antibody
Authors: Cox Kristin E. , Turner Michael A. , Lwin Thinzar M. , Amirfakhri Siamak , Kelly Kaitlyn J. , Hosseini Mojgan , Ghosh Pradipta , Obonyo Marygorret , Hoffman Robert M. , Yazaki Paul J. , Bouvet Michael 
Published: June 2024

Abstract
Background
Gastric cancer poses a major diagnostic and therapeutic challenge as surgical resection provides the only opportunity for a cure. Specific labeling of gastric cancer could distinguish resectable and nonresectable disease and facilitate an R0 resection, which could improve survival.

Methods
Two patient-derived gastric cancer lines, KG8 and KG10, were established from surgical specimens of two patients who underwent gastrectomy for gastric adenocarcinoma. Harvested tumor fragments were implanted into the greater curvature of the stomach to establish patient-derived orthotopic xenograft (PDOX) models. M5A (humanized anti-CEA antibody) or IgG control antibodies were conjugated with the near-infrared dye IRDye800CW. Mice received 50 µg of M5A-IR800 or 50 µg of IgG-IR800 intravenously and were imaged after 72 hr. Fluorescence imaging was performed by using the LI-COR Pearl Imaging System. A tumor-to-background ratio (TBR) was calculated by dividing the mean fluorescence intensity of the tumor versus adjacent stomach tissue.

Results
M5A-IR800 administration resulted in bright labeling of both KG8 and K10 tumors. In the KG8 PDOX models, the TBR for M5A-IR800 was 5.85 (SE ± 1.64) compared with IgG-IR800 at 0.70 (SE ± 0.17). The K10 PDOX models had a TBR of 3.71 (SE ± 0.73) for M5A-IR800 compared with 0.66 (SE ± 0.12) for IgG-IR800.

Conclusions
Humanized anti-CEA (M5A) antibodies conjugated to fluorescent dyes provide bright and specific labeling of gastric cancer PDOX models. This tumor-specific fluorescent antibody is a promising potential clinical tool to detect the extent of disease for the determination of resectability as well as to visualize tumor margins during gastric cancer resection.
Aquatic High-Intensity Interval Deep Water Running Influence on Cardiometabolic Health and Cognitive Psychological Responses in Women
Authors: KWOK MANNY M. Y. , NG SHAMAY S. M. , MYERS JONATHAN , SO BILLY C. L. 
Published: June 2024

ABSTRACT
Aquatic high-intensity interval training deep water running (AHIIT-DWR) has the potential to improve cardiometabolic health and cognitive psychological responses, offering a reduced risk of injuries and greater affordability for inactive elderly women.

Purpose
To investigate the effects of an 8-wk AHIIT-DWR intervention compared with land-based HIT training (LHIIT) on cardiometabolic health, cognitive, and psychological outcomes in inactive elderly women.

Methods
Seventy inactive elderly women aged 60 yr or above were randomly assigned into two groups: AHIIT-DWR and LHIIT. The AHIIT-DWR group engaged in DWR sessions comprising 30 min of interval training, consisting of ten 2-min exercise bouts at 80%–90% of their maximal heart rate (HRmax), with 1-min active recovery at 70% HRmax between bouts, for two sessions per week, for 8 wk. The LHIIT group performed treadmill running at the same intensity.

Results
Both groups showed similar cardiovascular fitness, maximal aerobic capacity (V̇O2max), HRmax, and RER improvement (P > 0.05), whereas AHIIT-DWR showed a significant improvement in aerobic capacity minute ventilation (V̇E), metabolic equivalents (METs), and O2 pulse (P < 0.05) over the 8-wk intervention. Both AHIIT-DWR and LHIIT significantly decreased triglycerides, total cholesterol, HDL, and LDL postintervention (P < 0.05). No significant group differences were observed for cognitive function assessed by MMSE and MOCA (P > 0.05). Both groups showed similar enjoyment levels, self-efficacy scores, and high adherence rates (>90%).

Conclusions
Our study suggests that AHIIT-DWR can elicit a similar improvement in cardiorespiratory health, metabolic blood markers, cognitive function assessed by MMSE and MOCA, and psychological responses as LHIIT in inactive elderly women.
A Fusion Pretrained Approach for Identifying the Cause of Sarcasm Remarks
Authors: Li Qiudan , Xu David Jingjun , Qian Haoda , Wang Linzi , Yuan Minjie , Zeng Daniel Dajun 
Published: June 2024

Sarcastic remarks often appear in social media and e-commerce platforms to express almost exclusively negative emotions and opinions on certain instances, such as dissatisfaction with a purchased product or service. Thus, the detection of sarcasm allows merchants to timely resolve users’ complaints. However, detecting sarcastic remarks is difficult because of its common form of using counterfactual statements. The few studies that are dedicated to detecting sarcasm largely ignore what sparks these sarcastic remarks, which could be because of an empty promise of a merchant’s product description. This study formulates a novel problem of sarcasm cause detection that leverages domain information, dialogue context information, and sarcasm sentences by proposing a pretrained language model-based approach equipped with a novel hybrid multihead fusion-attention mechanism that combines self-attention, target-attention, and a feed-forward neural network. The domain information and the dialogue context information are then interactively fused to obtain the domain-specific dialogue context representation, and bidirectionally enhanced sarcasm-cause pair representations are generated for detecting sarcasm spark. Experimental results on real-world data sets demonstrate the efficacy of the proposed model. The findings of this study contribute to the literature on sarcasm cause detection and provide business value to relevant stakeholders and consumers. History: Accepted by Ram Ramesh, Area Editor for Data Science and Machine Learning. Funding: This work was partially supported by the National Natural Science Foundation of China [Grants 72293575, 62071467, and 62141608] and the Research Grant Council of the Hong Kong Special Administrative Region, China [Grants 11500322 and 11500421]. Supplemental Material: The software that supports the findings of this study is available within the paper and its Supplemental Information ( https://pubsonline.informs.org/doi/suppl/10.1287/ijoc.2022.0285 ) as well as from the IJOC GitHub software repository ( https://github.com/INFORMSJoC/2022.0285 ). The complete IJOC Software and Data Repository is available at https://informsjoc.github.io/ .
Prevalence and impact of diabetes and prediabetes on presentation and complications of primary hyperaldosteronism at diagnosis
Authors: Sanyal Debmalya , Mukhopadhyay Pradip , Ghosh Sujoy 
Published: June 2024

BACKGROUND
Primary hyperaldosteronism (PH) is considered to contribute to increased risk of developing type 2 diabetes mellitus (T2DM) and prediabetes. Both PH and DM are associated with increased risk for hypertension, cardiovascular diseases, and chronic kidney diseases. However, data on prevalence of T2DM and prediabetes in PH, and impact of T2DM and prediabetes on presentation and cardio renal complications in PH at presentation is sparse.
AIM
To determine the prevalence of T2DM and prediabetes in PH at diagnosis and impact on presentation and complications of PH.
METHODS
A retrospective cohort study was conducted in tertiary care settings in individuals with confirmed diagnosis of PH at presentation. Demographic variables, clinical presentations, duration and degree of hypertension, complications, laboratory parameters including sodium, potassium levels, plasma aldosterone concentration (PAC), plasma renin activity (PRA), and aldosterone to renin ratio (ARR) and cardio-renal parameters were collected. Comparison was done between three groups: PH with no DM (Group A) or with pre-diabetes (Group B) or with T2DM (Group C). P < 0.05 was statistically significant.
RESULTS
Among 78 individuals with confirmed PH, 62% had pre-diabetes or diabetes; with 37% having DM. Mean duration of T2DM was 5.97 ± 4.7 years. The mean levels of glycaemic parameters among the group A vs B vs C individuals were fasting plasma glucose (mg/dL): 87.9 ± 6.5, 105.4 ± 9.02, 130.6 ± 21.1; post prandial plasma glucose (mg/dL): 122.7 ± 9.8, 154.9 ± 14, 196.7 ± 38.0; glycated haemoglobin (%) (5.3 ± 0.2, 5.9 ± 0.2, 7.5 ± 0.6, P < 0.05 ), respectively. There was no significant difference in the biochemical parameters (PAC, PRA, ARR, sodium, potassium levels), presentation and complications between the groups. Cardio renal parameters or degree and duration of hypertension were comparable between the groups.
CONCLUSION
Significant prevalence of T2DM and prediabetes in PH at diagnosis does not impact its presentation or complications. Early screening for undetected PH in T2DM and prediabetes subjects with hypertension may prevent complications.
Complicated calcified alloplastic implants in the nasal dorsum: A clinical analysis
Authors: Hwang Yong-Seon , Kim Taek-Kyun , Yang Dong-Jun , Jang Si-Hyong , Lee Da-Woon 
Published: June 2024

BACKGROUND
In rhinoplasty, calcification around silicone implants is frequently observed in the tip dorsum (TD) area. Additionally, based on a review of various literature, it is presumed that calcification in silicone implants occurs due to both inflammatory chemical reactions and physical friction against the tissue. The calcification of nasal silicone implants not only results in the functional loss of the implants, but also leads to material deformation. However, there is a lack of research on calcification of nasal silicone implants in the current literature.
AIM
To elucidate various clinical characteristics of calcification around nasal silicone implants, using histological and radiological analysis.
METHODS
This study analyzed data from 16 patients of calcified nasal implants, who underwent revision rhinoplasty for various reasons after undergoing augmentation rhinoplasty with silicone implants. The collected data included information on implant duration, implant types, location of calcification, presence of inflammatory reactions, and computed tomography (CT) scans.
RESULTS
The most common location of calcification, as visually analyzed, was in the TD area, accounting for 56%. Additionally, the analysis of CT scans revealed a trend of increasing Hounsfield Unit values for calcification with the duration of implantation, although this trend was not statistically significant (P = 0.139).
CONCLUSION
Our study shows that reducing the frequency of calcification may be achievable by using softer silicone implants and by minimizing the damage to perioperative tissues.
Comparative efficacy and safety of Chinese patent medicines of iron deficiency anemia during pregnancy: A network meta-analysis
Authors: Zou Jia-Chen , Jia Xian-Ling , Wang Hai-Xia , Su Ying-Jie , Zhu Jing-Yu 
Published: June 2024

BACKGROUND
Iron deficiency anemia (IDA) is a prevalent nutritional disorder during pregnancy. Clinical studies indicate that incorporating Chinese patent medicines (CPMs) with oral iron (OI) in treating IDA in pregnancy can reduce adverse effects and improve clinical outcomes. Nonetheless, the comparative efficacy of different CPMs remains unclear.
AIM
To assess the safety and effectiveness of different CPMs for treating IDA during pregnancy using network meta-analysis.
METHODS
We conducted a search for randomized controlled trials (RCTs) that combined CPM and OI for IDA treatment in pregnancy, spanning from 2013 to the present. Data analysis was performed using Rev Man 5.3 and Stata 14.0 on literature that satisfied the quality criteria.
RESULTS
The analysis included 45 RCTs, encompassing 4422 pregnant patients with IDA. Six CPMs were examined, including Shengxuebao Mixture, Shengxuening Tablets (SXN), Yiqi Weixue CPMs (YQWX), Jianpi Shengxue CPMs (JPSX), Yiqi Buxue Tablets, and Compound Hongyi Buxue Oral Liquid (FFHY). Findings indicated that FFHY + OI significantly improved the clinical effective rate. SXN + OI was most effective in boosting red blood cells counts and hemoglobin levels. YQWX + OI showed superior results in improving serum ferritin, and SXN + OI was most effective in increasing serum iron levels. JPSX + OI was optimal in reducing adverse pregnancy outcomes, while YQBX + OI effectively minimized adverse events. A cluster analysis suggested that SXN + OI could be the potentially optimal therapeutic regimen for IDA in pregnancy.
CONCLUSION
This study demonstrates that the combination of OI with CPMs offers better outcomes than OI alone. Based on clinical efficacy and other measured outcomes, SXN + OI emerges as the most effective treatment modality for improving the health of pregnant patients with IDA.
Emergency rescue of a patient with hemorrhagic shock caused by superior mesenteric artery rupture: A case report
Authors: Lin Xian-Ping , Guo Xin-Li , Tian He-Feng , Wu Zheng-Rong , Yang Wei-Jie , Pan Hong-Ying 
Published: June 2024

BACKGROUND
Superior mesenteric artery (SMA) injuries rarely occur during blunt abdominal injuries, with an incidence of < 1%. The clinical manifestations mainly include abdominal hemorrhage and peritoneal irritation, which progress rapidly and are easily misdiagnosed. Quick and accurate diagnosis and timely effective treatment are greatly significant in managing emergent cases. This report describes emergency rescue by a multidisciplinary team of a patient with hemorrhagic shock caused by SMA rupture.
CASE SUMMARY
A 55-year-old man with hemorrhagic shock presented with SMA rupture. On admission, he showed extremely unstable vital signs and was unconscious with a laceration on his head, heart rate of 143 beats/min, shallow and fast breathing (frequency > 35 beats/min), and blood pressure as low as 20/10 mmHg (1 mmHg = 0.133 kPa). Computed tomography revealed abdominal and pelvic hematocele effusion, suggesting active bleeding. The patient was suspected of partial rupture of the distal SMA branch. The patient underwent emergency mesenteric artery ligation, scalp suture, and liver laceration closure. In view of conditions with acute onset, rapid progression, and high bleeding volume, key points of nursing were conducted, including activating emergency protocol, opening of the green channel, and arranging relevant examinations with various medical staff for quick diagnosis. The seamless collaboration of the multidisciplinary team helped shorten the preoperative preparation time. Emergency laparotomy exploration and mesenteric artery ligation were performed to mitigate hemorrhagic shock while establishing efficient venous accesses and closely monitoring the patient’s condition to ensure hemodynamic stability. Strict measures were taken to avoid intraoperative hypothermia and infection.
CONCLUSION
After 3.5 h of emergency rescue and medical care, bleeding was successfully controlled, and the patient’s condition was stabilized. Subsequently, the patient was transferred to the intensive care unit for continuous monitoring and treatment. On the sixth day, the patient was weaned off the ventilator, extubated, and relocated to a specialized ward. Through diligent medical intervention and attentive nursing, the patient made a full recovery and was discharged on day 22. The follow-up visit confirmed the patient’s successful recovery.
Teacher, Professional or Both? A Mixed Method Study of the Professional Identity of Vocational Teachers and Trainers in Hungary
Authors: Bükki Eszter , Fehérvári Anikó 
Published: June 2024

Purpose: Vocational educators in many countries enter teaching as a second career and authentic occupational expertise is seen as essential to good quality VET. The changing contexts of VET and the growing diversity of its learning populations also demand the development of teaching expertise. This dual professionalism is related to a unique combination of an occupational and a teacher identity, however, prior, and mainly qualitative research from a limited number of VET contexts suggests that often one side of this duality prevails. Our study aimed to explore the professional identity of vocational educators in Hungary and to identify some of the factors that might influence its formation.
Methods: We applied a mixed method design, conducting a teacher survey (N=138) and semi-structured interviews (N=12). The quantitative and qualitative strands followed a parallel design, exploring the same topics but identity views and the organisational context were studied more deeply in the interviews. In the survey, we measured professional identity through a direct question about its type as well as questions about the importance of specific goals and teacher competence areas in vocational teaching. We used statistical and thematic analyses to study our quantitative and qualitative data.
Results: Most vocational educators in our study identified as both a teacher and a professional, though the type of identity varied by gender and length of occupational work experience. Perceptions about the main goals in teaching revealed vocation/outcome-focused and student/education-focused goal orientations influenced by gender, qualifications and work experience, while our qualitative data also showed the impact of school culture and the wider socio-economic context. The goal orientations identified in the survey were more balanced for those with a dual identity, and they correlated with perceptions about the importance of different teacher competence areas, which were most influenced by whether or not the educator had obtained a pedagogical qualification.
Conclusion: Our findings showed that although most vocational educators also in Hungary claim to have a dual identity, they often prioritise the development of occupational expertise as they believe it is what gives them credibility that is seen as essential to "good VET". Considering the significant impact we have found of teacher education and continued work in the occupation on identity views, it seems of utmost importance that policy and schools recognise and support the development of both occupational and teacher expertise, to ensure a balanced dual identity that seems best suited for vocational teaching.
Investigating the impact of cavity parameters on an ultrashort pulse in a fiber laser
Authors: Han X. , Yue J. , Huang Z. , Li J. , Yan X. , Xia Y. , Zhang G. , Zhang H. , Xia C. 
Published: June 2024

Fiber lasers have numerous applications in various fields due to their compact design, low noise levels, high efficiency, and robust stability. We present a study focusing on the impact of cavity parameters on ultrashort pulses in fiber lasers, proposing an ultrafast laser that utilizes a MoTe2 saturable absorber (SA). Here numerical simulations allowed us to analyze the diverse pulse dynamics within a laser cavity, incorporating a SA, a segment of passive fiber, and erbium-doped fiber (EDF). Key factors of second-order dispersion, nonlinearity, gain saturation energy, small signal gain coefficient, and modulation depth and saturable energy of the SA were simulated. According to the simulations, we obtained the parameter settings for the minimum output pulse duration using a neural network and genetic algorithm. Then we proposed a normal dispersion laser with a MoTe2 mode-locker, capable of emitting dissipative soliton with a pulse duration of 824 fs and a spectrum bandwidth of 13.2 nm. These simulations provide valuable guidance for the design and optimization of fiber lasers, presenting a versatile and practical approach for applications.
Redefining Histological Cell Counts Using a Standardized Method: The Leuven Intestinal Counting Protocol
Authors: Ceulemans Matthias , Huyghe Pauline , De Hertogh Gert , Cameron Raquel , Schol Jolien , Burns Grace L. , Keely Simon , Wauters Lucas , Tack Jan , Talley Nicholas J. , Vanuytsel Tim 
Published: June 2024

INTRODUCTION:The diagnosis of eosinophilic gastrointestinal diseases is largely based on mucosal eosinophil counts, but thresholds and normal ranges beyond the esophagus are debated, calling for much-needed methodological standardization. We aimed to develop a standardized workflow for duodenal cell quantification and estimate duodenal eosinophil and mast cell numbers in healthy controls.METHODS:Software-based histological cell quantification using free-sized or fixed-sized regions was developed and applied to digitized hematoxylin and eosin (H&E)-stained slides from 58 individuals (healthy controls [HCs] and patients with functional dyspepsia). Intraclass correlation coefficients (ICCs) compared inter-rater reliability between software-based and microscopic quantification. Reproducibility of the software-based method was validated in an independent cohort of 37 control and functional dyspepsia subjects. Eosinophil identification on H&E staining was compared to immunohistochemistry (IHC). Normal eosinophil (H&E) and mast cell (cKit) ranges were determined in 70 adult HCs.RESULTS:Eosinophil quantification on digitized slides demonstrated excellent (ICC = 0.909) and significantly improved reproducibility over microscopic evaluation (ICC = 0.796,P= 0.0014), validated in an independent cohort (ICC = 0.910). Duodenal eosinophils were more abundant around crypts than in villi (P< 0.0001), while counts were similar on matched H&E- and IHC-stained slides (P= 0.55). Mean ± SD (95th percentile) duodenal eosinophils and mast cells in HC were 228.8/mm2± 94.7 (402.8/mm2) and 419.5/mm2± 132.2 (707.6/mm2), respectively.DISCUSSION:We developed and validated a standardized approach to duodenal histological cell quantification, generalizable to various mucosal cell types. Implementation of software-based quantification identified 400 eosinophils/mm2and 700 mast cells/mm2as thresholds for abnormal duodenal infiltration.