bluuebunny/crossref_metadata_2025_split huggingface dataset:
Skeletal muscle differentiation induces wide-ranging nucleosome repositioning in muscle gene promoters
Authors: Harris Sonalí , Anwar Iqra , Baksh Syeda S. , Pratt Richard E. , Dzau Victor J. , Hodgkinson Conrad P. 
Published: April 2024

AbstractIn a previous report, we demonstrated that Cbx1, PurB and Sp3 inhibited cardiac muscle differentiation by increasing nucleosome density around cardiac muscle gene promoters. Since cardiac and skeletal muscle express many of the same proteins, we asked if Cbx1, PurB and Sp3 similarly regulated skeletal muscle differentiation. In a C2C12 model of skeletal muscle differentiation, Cbx1 and PurB knockdown increased myotube formation. In contrast, Sp3 knockdown inhibited myotube formation, suggesting that Sp3 played opposing roles in cardiac muscle and skeletal muscle differentiation. Consistent with this finding, Sp3 knockdown also inhibited various muscle-specific genes. The Cbx1, PurB and Sp3 proteins are believed to influence gene-expression in part by altering nucleosome position. Importantly, we developed a statistical approach to determine if changes in nucleosome positioning were significant and applied it to understanding the architecture of muscle-specific genes. Through this novel statistical approach, we found that during myogenic differentiation, skeletal muscle-specific genes undergo a set of unique nucleosome changes which differ significantly from those shown in commonly expressed muscle genes. While Sp3 binding was associated with nucleosome loss, there appeared no correlation with the aforementioned nucleosome changes. In summary, we have identified a novel role for Sp3 in skeletal muscle differentiation and through the application of quantifiable MNase-seq have discovered unique fingerprints of nucleosome changes for various classes of muscle genes during myogenic differentiation.
An improved corner dealiasing and recognition algorithm for 2D Wadell roundness computation
Authors: Chen Jianhuang , Zhang Zhongjian , Lin Daming , Li Lihui , Xu Wenjie 
Published: April 2024

AbstractThis paper optimizes the 2D Wadell roundness calculation of particles based on digital image processing methods. An algorithm for grouping corner key points is proposed to distinguish each independent corner. Additionally, the cyclic midpoint filtering method is introduced for corner dealiasing, aiming to mitigate aliasing issues effectively. The relationships between the number of corner pixels (m), the central angle of the corner (α) and the parameter of the dealiasing degree (n) are established. The Krumbein chart and a sandstone thin section image were used as examples to calculate the 2D Wadell roundness. A set of regular shapes is calculated, and the error of this method is discussed. When α ≥ 30°, the maximum error of Wadell roundness for regular shapes is 5.21%; when 12° ≤ α < 30°, the maximum error increases. By applying interpolation to increase the corner pixels to the minimum number (m0) within the allowable range of error, based on the α-m0 relational expression obtained in this study, the error of the corner circle can be minimized. The results indicate that as the value of m increases, the optimal range interval for n also widens. Additionally, a higher value of α leads to a lower dependence on m. The study's results can be applied to dealiasing and shape analysis of complex closed contours.
The influence of hot isostatic pressing on precipitates, mechanical properties of Mg-12Gd-0.8Zn-0.4Zr (wt.%) alloy manufactured by sand casting
Authors: Wang Dan , Ma Chao , Chen Ye , Gu Li , Yu Yangyang 
Published: April 2024

AbstractMicrostructures and mechanical properties of Mg-12Gd-0.8Zn-0.4Zr (GZ1208K, wt.%) alloy under different treatments (as-cast: signed as nonHIP-GZ1208K, hot isostatic pressing (HIP): signed as HIP-GZ1208K) were characterized. Based on microstructure characterization, two prismatic precipitates, β′ and β1 precipitates, and one basal precipitate, γ′ precipitate, formed in both of nonHIP-GZ1208K and HIP-GZ1208K alloy. According to analysis, the area number density and the size of β′ precipitate could be adjusted through HIP treatment. The area number density of β′ precipitate increased after HIP treatment when aged at 32 h, and the size of β′ precipitate refined in both of the HIP-GZ1208K alloy aged at 8 h and 32 h. Except the influence of HIP treatment on microstructures, the ultimate tensile strength (UTS) and elongation of nonHIP-GZ1208K alloy also improved after HIP treatment. The UTS of the GZ1208K alloy aged at 8 h increased from 348 MPa (nonHIP-) to 371 MPa (HIP-) and the elongation increased from 2.6% to 4.7%. The density of the nonHIP-GZ1208K alloy increased after HIP treatment, that is to say the casting defects could be eliminated and the compactness of microstructures could be increased under the high pressure of HIP treatment.
Warming climate is helping human beings run faster, jump higher and throw farther through less dense air
Authors: Wang Shixin , Chen Tiexi , Luo Jing-Jia , Gao Meng , Zuo Hongchao , Ling Fenghua , Hu Jianlin , Yuan Chaoxia , Yang Yuanjian , Wang Lina , Huang Huaming , Wang Naiang , Li Yaojun , Yamagata Toshio 
Published: April 2024

AbstractUnderstanding both positive and negative impacts of climate change is essential for comprehensively assessing and well adapting to the impacts of changing climate. Conventionally, climate warming is revealed to negatively impact human activities. Here, we reveal that human beings’ performance in anaerobic sports may benefit from climate warming. Using global weather observation and athletes’ performance datasets, we show that world-top athletes’ performances in nearly all athletics anaerobic events (i.e., sprints, jumps and throws) substantially improve as ambient temperature rises. For example, 100 m performance monotonically improves by 0.26 s as ambient temperature rises from 11.8° to 36.4 °C. Using Coupled Model Intercomparison Project Phase 6 datasets, we further show that global warming can substantially improve world-top athletes’ performance in eleven of the thirteen Olympics athletics anaerobic events by 0.27%–0.88% and 0.14–0.48% under high-emission and medium-emission scenarios, respectively, during 1979–2100. Among them, the improvements for 100 m are 0.59% (0.063 s) and 0.32% (0.034 s), respectively. Mechanism analysis shows that the warmed ambient atmosphere can improve competitors’ performance through expanding the air and thus reducing the air resistance to the competitors and throwing implements for hummer throw and all the sprints, hurdling and jumps. Quantitative analysis estimates that this thermodynamic process is essential for the impacts of warmed ambient atmosphere on the performances in these events as physiological processes are.
Assessing the feasibility of near-ambient conditions superconductivity in the Lu-N-H system
Authors: Fang Yue-Wen , Dangić Đorđe , Errea Ion 
Published: April 2024

AbstractThe report of near-ambient superconductivity in nitrogen-doped lutetium hydrides (Lu-N-H) has generated a great interest. However, conflicting results raised doubts regarding superconductivity. Here, we combine high-throughput crystal structure predictions with a fast predictor of superconducting critical temperature (Tc) based on electron localization function to shed light on the properties of Lu-N-H at 1 GPa. None of the predicted structures supports high-temperature superconductivity and the inclusion of nitrogen in the crystal structure predictions leads to more insulating structures than metallic ones in quantity. Despite the lack of near-ambient superconductivity, we consider alternative metastable templates and study their Tc and dynamical stability including quantum anharmonic effects. Lu4H11N exhibits a Tc of 100 K at only 20 GPa, a large increase compared to 30 K of its parent LuH3. Interestingly, it has a similar X-ray pattern to the experimental one. The LaH10-like LuH10 and CaH6-like LuH6 become high-temperature superconductors at 175 GPa and 100 GPa, with Tc of 286 K and 246 K, respectively. Our findings suggest that high-temperature superconductivity is not possible in stable phases at near-ambient pressure. However, at a slightly enhanced pressure of 20 GPa, high-Tc superconductivity emerges in Lu-H-N, and metastable room-temperature superconducting templates persist at high pressures.
Reframing trait trade-offs in marine microbes
Authors: Levine Naomi M. , Doblin Martina A. , Collins Sinéad 
Published: April 2024

AbstractThe oceans sequester a vast amount of carbon thus playing a central role in the global carbon cycle. Assessing how carbon cycling will be impacted by climate change requires an improved understanding of microbial dynamics, which are responsible for most carbon transformations in the oceans. Current numerical models used for predicting future states represent simplified microbial phenotypes and thus may not produce robust predictions of microbial communities. We propose reframing approaches for studying microbial trait change to allow for selection on multi-trait phenotypes. Integrating statistical approaches and trait-based models will allow for the incorporation of evolution into carbon cycle predictions.
Resource allocation and passive beamforming for IRS‐assisted short packet systems
Authors: Zhang Yangyi , Guan Xinrong , Wu Qingqing , Ji Zhi , Cai Yueming 
Published: April 2024

AbstractThis paper investigates an intelligent reflecting surface (IRS) assisted downlink short packet transmission system, where an access point sends short packets to multiple devices with the help of an IRS. Specifically, a performance comparison between the frequency division multiple access and time division multiple access is conducted for the considered system, from the perspective of average age of information (AoI). To minimize the maximum average AoI among all devices, the resource allocation and passive beamforming are jointly optimized. However, the formulated problem is difficult to solve due to the non‐convex objective function and coupled variables. Thus, an alternating optimization based algorithm is proposed by exploiting the semidefinite relaxation and bisection search techniques. Simulation results show that time division multiple access can achieve lower AoI by exploiting the time‐selective passive beamforming of IRS for maximizing the signal to noise ratio of each device consecutively. Moreover, it also shows that as the length of information bits becomes sufficiently large as compared to the available bandwidth, the proposed frequency division multiple access transmission scheme becomes more favourable due to more flexible power allocation.
Analysis of KLRB1-Mediated Immunosuppressive Regulation in Adamantinomatous Craniopharyngioma
Authors: Wei Wei , Hong Tao 
Published: April 2024

Abstract
Background Adamantinomatous craniopharyngioma (ACP) is the most common type of craniopharyngioma (CP). Under the current surgery and/or radiotherapy strategies, the survival rate is high, but the long-term quality of life is poor because of the relationship between the hypothalamic–pituitary axis and the tumor. Many studies had shown that endocrine deficiencies caused by craniopharyngiomas of the hypothalamic–pituitary axis persist throughout almost the entire life of the patients after surgery, requiring them to receive hormone replacement therapy. Thus, we need to explore new treatments to improve the prognosis of patients. In recent years, there are more and more studies on the immunotherapy of various tumors. However, due to the rarity of the disease, immunotherapy for ACP is rarely researched. The discovery of the tumor immune-suppressive checkpoint KLRB1 (killer cell lectinlike receptor B1), which encodes CD161, may provide a novel target for the treatment of ACP.
Methods Data analysis of retrospective RNA sequencing was conducted in a cohort of 51 pediatric samples in the GSE94349 dataset, and the results were well validated in the GSE68015 dataset including 31 pediatric samples. We used R language as the main tool for statistical analysis and graphical work.
Results Our research showed that KLRB1 was enriched in ACP. Additionally, the expression of KLRB1 was positively related to immune functions and most inflammatory responses of ACP. We found that most of the T lineage–related immune responses were positively correlated with KLRB1 expression, and KLRB1 played an important role in the activation of inflammatory processes.
Conclusions KLRB1 is a promising target for immunotherapeutic strategies.
Mucormycosis Associated with COVID-19
Authors: Gajjela Bhavya , Mathias Michelle , Sajitha K. 
Published: April 2024

AbstractMucormycosis is an angioinvasive disease caused by fungi of the order Mucorales. In this article, three case reports of rhinocerebral mucormycosis developing after COVID-19 infection in a diabetic patient are presented. Early diagnosis and treatment of those high morbidity conditions are vital to better outcomes.
A Study on Use of Interdental Brushes among Patients Who are Undergoing Fixed Orthodontic Treatment: An Epidemiological Survey
Authors: Bhat Amitha Ramesh , Gupta Ayush , Meghana Ivaturi Sri Sai , Nair Karthika Sureshkumar , Thomas Biju , Bhandary Rahul , Shetty Akshatha 
Published: April 2024

Abstract
Introduction Maintenance of periodontal health is very important during fixed orthodontic treatment as accumulation of plaque can cause dental challenges that may interfere with orthodontic treatment; hence the present investigation was carried out to examine the knowledge of patients who were using interdental brushes during fixed orthodontic treatment.
Methods Total 150 subjects aged 14 to 30 years from Mangalore city were selected. Majority of them were in the age group of 14 to 18 years (39.33%). Overall, 77 females (51.3%) and 73 males (48.7%) who were undergoing fixed orthodontic treatment and had given consent for the participation in epidemiological questionnaire survey were included. Demographic information and use of interdental brushes during fixed orthodontic treatment for maintaining periodontal health were included in the survey.
Result Overall, 58% of the participants undergoing fixed orthodontic treatment were using interdental brushes, which was statistically significant. The frequency of using interdental brush was 72.4%, 19.5%, and 8.04% daily, weekly, and monthly, respectively.
Conclusion The majority of the study participants who sought fixed orthodontic treatment were using interdental brushes daily in order to maintain periodontal health, which was statistically significant. Patient education and motivation was shown to be strongly associated with maintaining of periodontal health among study participants.
Perceptual and Acoustic Correlates of Voice in COVID-19 Infection
Authors: Rahul Akhila , Joseph Bennet Elsa , Sada Shwetha 
Published: April 2024

AbstractAccording to the information published by the World Health Organization in 2020, coronavirus disease, abbreviated as COVID-19, is an infectious disease caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus. The virus is reported to result in mild to moderate respiratory illness, significantly affecting vocal mechanisms. The present study explored the effects of a recent COVID-19 infection on perceptual, self-reported outcomes, and acoustic measures of voice. The study was conducted on 25 COVID-19-infected patients and was compared against a group of age- and gender-matched healthy individuals. Perceptual evaluation, self-reported voice outcomes using Voice Handicap Index (VHI-10), and acoustic analysis were conducted on the two groups of participants. The results revealed significant differences in perceptual and acoustic parameters of voice between the two groups.
Epidemiology of Japanese Encephalitis in Central India after Implementing Immunization
Authors: Tandale Babasaheb V. , Khude Poornima M. , Deshmukh Pravin S. , Qazi Mohiuddin S. , Padmaja Goteti V. , Narang Rahul , Deshmukh Pradeep R. , Rajderkar Shekhar S. , Tomar Shilpa J. , Bondre Vijay P. , Sapkal Gajanan N. , Damle Rekha G. , Jain Manish , Jain Dipty , Guduru Vijay Kumar , Jain Jyoti , Gosavi Rajesh V. , Sekhar V. Chandra , Raut Abhishek V. , Narlawar Uday W. , Jha Punam Kumari , Niswade Abhimanyu K. , Talapalliwar Manoj , Rathod Pragati , Soujanya B. Padmini , Kumar M. Pavan , Kumar K. J. Kishore ,   Japanese Encephalitis Epidemiology in Central India Study Group
Published: April 2024

Abstract
Objective We report the epidemiology of Japanese encephalitis (JE) disease after the implementation of routine immunization in medium-endemic districts in the states of Maharashtra and Telangana in Central India.
Methods We investigated acute encephalitis syndrome (AES) patients hospitalized from October 2018 to September 2020. Field visits were also made to the residences of 262 AES cases, including 54 JE cases.
Results The overall case fatality ratio was 31%. Maharashtra state contributed 72% of JE and 67% of AES cases. The rural localities had a significantly higher number of JE cases than the urban areas. The occurrence of JE was reported year round, with most JE cases reported during the rainy season. Both AES and JE cases were reported mostly among children, with JE in 66% and non-JE AES in 70% of children.
Conclusion The JE disease continues to affect the population after routine immunization. Surveillance, prevention, and control need to be enhanced to achieve accelerated control.
Lymphovenous Bypass for Immediate Lymphatic Reconstruction in Breast Cancer Patients Undergoing Axillary Lymph Node Dissection: Minimizing the Risk of Upper Extremity Lymphedema
Authors: Médor Maria C. , Churchill Isabella F. , Pereira Diego , Roberts Amanda , Cordeiro Erin , Findlay-Shirras Lisa , Zhang Jing , Momtazi Moein 
Published: April 2024

Abstract
Background Studies have shown a significant reduction in breast cancer-related lymphedema (BCRL) rates in patients undergoing complete axillary lymph node dissection (cALND) combined with immediate lymphatic reconstruction (ILR) using lymphovenous bypass (LVB).The purpose of this study was to determine if ILR with LVB at the time of cALND results in a decreased incidence of BCRL and its impact on patient quality of life (QOL).
Methods In this prospective cohort study, patients ≥ 18 years requiring cALND underwent ILR from 2019 to 2021. The primary outcome was bilateral upper limb volumes measured by Brørson's truncated cone formula and the Pero-System (3D Körper Scanner). The secondary outcome was QOL measured by the Lymphedema Quality of Life (LYMQOL) arm patient-reported outcome measurement.
Results Forty-two patients consented to ILR using LVB. ILR was completed in 41 patients with a mean of 1.9 ± 0.9 lymphovenous anastomosis performed. Mean age of patients was 52.4 ± 10.5 years with a mean body mass index of 27.5 ± 4.9 kg/m2. All patients (n = 39, 100%) received adjuvant therapy after ILR. Mean follow-up was 15.2 ± 5.1 months. Five patients met criteria for lymphedema throughout the duration of the study (12.8%), with two patients having resolution, with an overall incidence of 7.7% by the end of the study period. Patients with lymphedema were found to have statistically significant lower total LYMQOL values at 18 months (8.44 ± 1.17 vs. 3.23 ± 0.56, p < 0.001). A mean increase of 0.73 ± 3.5 points was observed for overall QOL average for upper limb function at 18 months compared with 3 months (t = 0.823, p = 0.425).
Conclusion This study showed an incidence of 7.7% lymphedema development throughout the duration of study. We also showed that ILR has the potential to reduce the significant long-term adverse outcomes of lymphedema and improve QOL for patients undergoing cALND
The Natural History of Non-operatively Treated Traumatic Triangular Fibrocartilage Complex Tears: A Systematic Review
Authors: Choi Seung Il , Malik Shahbaz , MacLean Simon 
Published: April 2024

Abstract
Purpose Operative treatment of triangular fibrocartilage complex (TFCC) tears has been well researched; however, data regarding nonoperative management is mixed and scarce. Our review aimed to utilize available data to formulate conclusions regarding treatment algorithms for this heterogeneous injury group.
Methods A thorough literature review was performed in Medline (OVID), Embase, Cochrane Library, and PubMed databases with search terms including “triangular fibrocartilage complex” and variations on the full term including “triangular fibrocartilage” or “TFCC,” alongside “non-operative” and “conservative.” Results were then subject to inclusion criteria, ultimately identifying eight studies.
Results The studies involved a total of 425 patients and 427 wrists for analysis. The mean age ranged from 30.7 years to 60.4 years. 53.6% of patients were male. The mean follow-up ranged from 12 months to 7 years, with an overall mean follow-up period of 27 months. Primary endpoints focused on various functional outcome scores, range of motion, grip strength, and pain. The nonoperative management of TFCC tears resulted in noninferior and comparable outcomes to operative management.
Conclusion Our review identified that the nonoperative management of Palmer-type IB tears with a short period of above-elbow immobilization was an effective treatment option with good functional outcome scores. The nonoperative management of general TFCC tears resulted in comparable functional outcomes when viewed alongside results from other systematic reviews. Risk factors for developing a poor functional outcome or requiring operative management included distal radioulnar joint subluxation, short-arm immobilization, and full tears of the foveal attachment. However, further randomized controlled trials with homogenous data collection are required to make further conclusions regarding the management of this condition.
A two-magnet energy harvesting device with buoy base for a marine terminal
Authors: Chiu Min-Chie , Cheng Ho-Chih , Her Ming-Guo 
Published: April 2024

It is crucial to explore new green energy sources to alleviate the earth’s energy depletion and the impact of air pollution and greenhouse effects. Although wafer manufacturing is increasing worldwide, the implementation of carbon footprint policies necessitates a shift toward green electricity. To expand the scale of wafer manufacturing, it is essential to develop terrestrial green electricity, which requires additional terrestrial green energy sources. This paper presents a green energy harvesting method that generates wave hydraulic energy via a vibration-based electromagnetic generator through a buoy. An energy harvester composed of two magnets in series driven by a buoy via a connected pole is introduced. The sensitivity of induced electricity to the energy harvester’s design parameters, including the magnets’ geometric dimensions (diameter and height), the coil’s turns, and layers, is analyzed. Additionally, the relationship between electricity and wave information (wave amplitude and wavelength) is explored. To evaluate the electrical power efficiency between a pair of single-magnet energy harvesters and the two-magnet harvester, a pair of parallel energy harvesters consisting of one magnet and paralleled in line is assessed. The impact of electricity on the horizontal span between the parallel energy harvesters is also investigated. To achieve maximal electricity, the two-magnet energy harvester is numerically optimized using a simulated annealing method. The numerical result shows that the two-magnet (in series) energy harvester can produce 0.472 W when the wavelength is 0.03, the amplitude is 0.09 m, and the wave speed is 3 m/s.