bluuebunny/crossref_metadata_2025_split huggingface dataset:
Potential Gradient‐Driven Dual‐Functional Electrochromic and Electrochemical Device Based on a Shared Electrode Design
Authors: Xu Gang , Zhang Wei , Zhu Guangjun , Xia Huan , Zhang Hanning , Xie Qian , Jin Peng , Zhang Haoyu , Yi Chengjie , Zhang Ruqian , Ji Lingfeng , Shui Tao , Moloto Nosipho , She Wei , Sun ZhengMing 
Published: May 2024

AbstractThe integration of electrochromic devices and energy storage systems in wearable electronics is highly desirable yet challenging, because self‐powered electrochromic devices often require an open system design for continuous replenishment of the strong oxidants to enable the coloring/bleaching processes. A self‐powered electrochromic device has been developed with a close configuration by integrating a Zn/MnO2 ionic battery into the Prussian blue (PB)‐based electrochromic system. Zn and MnO2 electrodes, as dual shared electrodes, the former one can reduce the PB electrode to the Prussian white (PW) electrode and serves as the anode in the battery; the latter electrode can oxidize the PW electrode to its initial state and acts as the cathode in the battery. The bleaching/coloring processes are driven by the gradient potential between Zn/PB and PW/MnO2 electrodes. The as‐prepared Zn||PB||MnO2 system demonstrates superior electrochromic performance, including excellent optical contrast (80.6%), fast self‐bleaching/coloring speed (2.0/3.2 s for bleaching/coloring), and long‐term self‐powered electrochromic cycles. An air‐working Zn||PB||MnO2 device is also developed with a 70.3% optical contrast, fast switching speed (2.2/4.8 s for bleaching/coloring), and over 80 self‐bleaching/coloring cycles. Furthermore, the closed nature enables the fabrication of various flexible electrochromic devices, exhibiting great potentials for the next‐generation wearable electrochromic devices.
Gold‐Catalyzed Arylative Cope Rearrangement
Authors: Paroi Bidisha , Pegu Chayanika , Mane Manoj V. , Patil Nitin T. 
Published: May 2024

AbstractCope rearrangements have garnered significant attention owing to their ability to undergo structural reorganization in stereoselective manner. While substantial advances have been achieved over decades, these rearrangements remained applicable exclusively to parent 1,5‐hexadienes. Herein, we disclose the gold‐catalyzed arylative Cope rearrangement of 1,6‐heptadienes via a cyclization‐induced [3,3]‐rearrangement employing ligand‐enabled gold redox catalysis. Detailed mechanistic investigations including several control experiments, cross‐over experiment, HRMS analysis, 31P NMR and DFT studies have been performed to underpin the mechanism.
Suppressed Dissolution of Fluorine‐Rich SEI Enables Highly Reversible Zinc Metal Anode for Stable Aqueous Zinc‐Ion Batteries
Authors: Zhang Yanan , Shen Shenyu , Xi Kai , Li Peng , Kang Zihan , Zhao Jianyun , Yin Dandan , Su Yaqiong , Zhao Hongyang , He Guanjie , Ding Shujiang 
Published: May 2024

AbstractThe instability of the solid electrolyte interface (SEI) is a critical challenge for the zinc metal anodes, leading to an erratic electrode/electrolyte interface and hydrogen evolution reaction (HER), ultimately resulting in anode failure. This study uncovers that the fluorine species dissolution is the root cause of SEI instability. To effectively suppress the F− dissolution, an introduction of a low‐polarity molecule, 1,4‐thioxane (TX), is proposed, which reinforces the stability of the fluorine‐rich SEI. Moreover, the TX molecule has a strong affinity for coordinating with Zn2+ and adsorbing at the electrode/electrolyte interface, thereby diminishing the activity of local water and consequently impeding SEI dissolution. The robust fluorine‐rich SEI layer promotes the high durability of the zinc anode in repeated plating/stripping cycles, while concurrently suppressing HER and enhancing Coulombic efficiency. Notably, the symmetric cell with TX demonstrates exceptional electrochemical performance, sustaining over 500 hours at 20 mA cm−2 with 10 mAh cm−2. Furthermore, the Zn||KVOH full cell exhibits excellent capacity retention, averaging 6.8 mAh cm−2 with 98 % retention after 400 cycles, even at high loading with a lean electrolyte. This work offers a novel perspective on SEI dissolution as a key factor in anode failure, providing valuable insights for the electrolyte design in energy storage devices.
Ribosomal dormancy at the nexus of ribosome homeostasis and protein synthesis
Authors: Koli Saloni , Shetty Sunil 
Published: May 2024

AbstractDormancy or hibernation is a non‐proliferative state of cells with low metabolic activity and gene expression. Dormant cells sequester ribosomes in a translationally inactive state, called dormant/hibernating ribosomes. These dormant ribosomes are important for the preservation of ribosomes and translation shut‐off. While recent studies attempted to elucidate their modes of formation, the regulation and roles of the diverse dormant ribosomal populations are still largely understudied. The mechanistic details of the formation of dormant ribosomes in stress and especially their disassembly during recovery remain elusive. In this review, we discuss the roles of dormant ribosomes and their potential regulatory mechanisms. Furthermore, we highlight the paradigms that need to be answered in the field of ribosomal dormancy.
Insights into the Biological Activities and Substituent Effects of Pyrrole Derivatives: The Chemistry‐Biology Connection
Authors: Manya B. S. , Kumar M. R. Pradeep , Rajagopal Kalirajan , Hassan Md. Abul , Rab Safia Obaidur , Alshehri Mohammed Ali , Emran Talha Bin 
Published: May 2024

AbstractPyrrole, with its versatile heterocyclic ring structure, serves as a valuable template for generating a diverse range of lead compounds with various pharmacophores. Researchers and scientists globally are intrigued by pyrrole and its analogs for their broad pharmacological potential, prompting thorough investigations aimed at advancing human welfare. This comprehensive review delves into the diverse activities exhibited by pyrrole compounds, encompassing their synthesis, reactions, and pharmacological properties alongside their derivatives. In addition to detailing the characteristics of pyrrole and its derivatives within the context of green chemistry, the review also examines microwave‐assisted reactions. It provides insights into their chemical structures, natural occurrences, and potential applications across various domains. Furthermore, the article investigates structural alterations of pyrrole compounds and their implications on their functionality, highlighting their versatility as foundational elements for both functional materials and bioactive compounds. The review emphasizes the need for ongoing research and development in the field of pyrrole compounds to discover new activities and benefits.
Graphiumisides A–D, Monoterpene Glycosides from an Animal‐Derived Endophytic Fungus Graphium sp. GD‐11
Authors: Zhang Mingyue , Zhang Yuhang , Ji Mengshan , Li Dongyang , Wang Haibo , Wang Xiaowei , Wei Wenjun , Hui Chengcheng , Guo Tao 
Published: May 2024

AbstractFour new monoterpene rhamnosides, graphiumisides A–D (1–4), along with four known steroid compounds (5–8) were isolated from the fermentation extract of animal‐derived endophytic fungus, Graphium sp. GD‐11. The chemical structures of all compounds were elucidated using 1D and 2D NMR, HRESIMS spectroscopic analyses, and other spectroscopic methods. Compounds 1–4 exhibit a distinctive structure connected by one p‐menthane type monoterpene and one L‐rhamnose. This is the first report of monoterpene glycosides from Graphium sp. All compounds (1–8) were tested for cytotoxic activities against four cancer cell lines (HepG2, SMMC7721, SW480, and A549), and only compound 1 showed weak anti‐tumor activity against SMMC7721 cells.
Carrier‐Free Disulfiram Based Nanomedicine for Enhanced Cancer Therapy
Authors: Dang Meng , Lu Nan , Shi Xuzhi , Li Qiang , Lin Bin , Dong Heng , Han Xiaolin , Rui Jiaxin , Sun Junfen , Luo Wei , Teng Zhaogang , Su Xiaodan 
Published: May 2024

AbstractNumerous nanomedicines have been developed to improve the efficiency and safety of conventional anticancer drugs. However, the carrier materials and intricate nature of multifunctional design always hindered the clinical transformation of nanomedicines. Herein, a novel carrier‐free anticancer nanomedicine (CFDC) with tailored morphologies including nanodots, nanorod and nanosheet were prepared using the clinically approved anti‐alcoholism drug disulfiram (DSF) via supramolecular assembly process. Our study reveals that CFDC induces the production of reactive oxygen species and activates the downstream apoptosis‐related c‐Jun N‐terminal kinase (JNK) and p‐38 pathway. In addition, the CFDC effectively counteract the inhibitory effect of NF‐κB expression on ROS‐induced cellular cytotoxicity, ultimately resulting in enhanced cell apoptosis, which is not achievable by pure DSF and the simply mixing of DSF and Cu2+ (DSF+Cu). Notably, the CFDC exhibits 3.1‐, 3.0‐folds increased on cancer cell DNA damage compared with the DSF, and DSF+Cu groups. In vivo experiments conducted on breast‐ or prostate‐bearing mice modals demonstrated that the CFDC exhibits a higher efficacy in suppressing the tumor growth. The remarkable drug delivery efficiency and better anticancer effect of CFDC nanodrug provide promising prospects for the clinical transformation of DSF based nanodrug in cancer therapy.
Gestational diabetes mellitus is associated with distinct folate‐related metabolites in early and mid‐pregnancy: A prospective cohort study
Authors: Zheng Wei , Zhang Yujie , Zhang Puyang , Chen Tengda , Yan Xin , Li Lin , Shao Lijun , Song Zhiru , Han Weiling , Wang Jia , Huang Junhua , Ma Kaiwen , Yang Ruihua , Ma Yuru , Xu Lili , Zhang Kexin , Yuan Xianxian , Li Guanghui 
Published: May 2024

AbstractAimsThis study aimed to evaluate the association between gestational diabetes mellitus (GDM) and circulating folate metabolites, folic acid (FA) intake, and the methylenetetrahydrofolate reductase (MTHFR) and methionine synthase reductase (MTRR) genotype.Materials and MethodsA prospective pregnancy cohort study was conducted in Beijing, China, from 2022 to 2023. Circulating folate metabolites, including red blood cell (RBC) 5‐methyltetrahydrofolate (5‐MTHF), 5, 10‐methylene‐tetrahydrofolate (5,10‐CH2‐THF), 5‐ formyltetrahydrofolate (5‐CHO‐THF), and unmetabolised folic acid (UMFA), and plasma homocysteine (HCY), 5‐MTHF, and methylmalonic acid (MMA), were determined at 6–17 weeks and 20–26 weeks of gestation. FA intake and the MTHFR and MTRR genotype were also examined. GDM was diagnosed between 24 and 28 weeks of pregnancy by a 75‐g oral glucose tolerance test (OGTT). The association between the folate status and GDM was ascertained using multivariate generalised linear models, logistic regression models, and restricted cubic spline regression, adjusting for potential confounders.ResultsThe study included 2032 pregnant women, of whom 392 (19.29%) developed GDM. UMFA above the 75th percentile (≥P75) [adjusted OR (aOR) (95% confidence interval [CI]) = 1.36 (1.01–1.84)], UMFA ≥ P90 [aOR (95% CI) = 1.82 (1.23–2.69)], and HCY ≥ P75 [aOR (95% CI) = 1.40 (1.04–1.88)] in early pregnancy, and RBC 5‐MTHF [aOR (95% CI) = 1.48 (1.10–2.00)], RBC 5,10‐CH2‐THF [aOR (95% CI) = 1.55 (1.15–2.10)], and plasma 5‐MTHF [aOR (95% CI) = 1.36 (1.00–1.86)] in mid‐pregnancy ≥ P75 are associated with GDM. Higher UMFA levels in early pregnancy show positive associations with the 1‐h and 2‐h glucose levels during the OGTT, and higher HCY levels are associated with increased fasting glucose levels during the OGTT. In comparison, RBC 5‐ MTHF and 5,10‐CH2‐THF, and plasma 5‐ MTHF in mid‐pregnancy are positively associated with the 1‐h glucose level (p < 0.05). The MTHFR and MTRR genotype and FA intake are not associated with GDM.ConclusionsElevated levels of UMFA and HCY during early pregnancy, along with elevated RBC 5‐MTHF and 5,10‐CH2‐THF and plasma 5‐MTHF during mid‐pregnancy, are associated with GDM. These findings indicate distinct connections between different folate metabolites and the occurrence of GDM.
Association Between Insulin Resistance Indices and Liver Function Parameters Among Women With Polycystic Ovary Syndrome
Authors: Saei Ghare Naz Marzieh , Mousavi Maryam , Firouzi Faezeh , Momenan Amir Abbas , Azizi Fereidoun , Ramezani Tehrani Fahimeh 
Published: May 2024

ABSTRACTObjectiveThis study aimed to investigate whether polycystic ovary syndrome (PCOS) status changes the association between insulin resistance (IR) indices and liver function parameters among women.MethodsThis is a cross‐sectional, population‐based study. We selected 1101 subjects aged ≥20 years from participants of Tehran Lipid and Glucose Study (TLGS). All of them had known the status of PCOS, and all variables were related to the IR indices and liver function parameters. The main outcome measures were TG/HDL‐C and triglyceride‐glucose (TyG) and liver function parameters (hepatic steatosis index [HSI], alanine transaminase [ALT] and aspartate transaminase [AST]).ResultIn the present study, there was no significant difference between the PCOS and the non‐PCOS regarding the presence of liver function abnormalities. A model adjusted by age and BMI showed that the upper tertile of TyG index was positively associated with high AST (OR = 3.04 [95% CI: 1.20–7.68], p < 0.05), high ALT (4.76 [3.07–7.36], p < 0.05) and high HSI (8.44 [1.82–39.17], p < 0.05). Although the history of diabetes had a positive impact on elevated AST (1.66 [1.15, 2.40], p < 0.05), the third tertile of TG/HDL‐C was associated with increased odds of elevated ALT (3.35 [2.21–5.06]) and HSI (6.55 [1.17–36.46]), whereas the second tertile of TG/HDL‐C (OR = 2.65, CI 95%: 1.74–4.03) was also positively associated with elevated ALT. PCOS had no significant association with elevated liver function tests.ConclusionThe highest tertile of TyG index and the TG/HDL‐C ratio as a surrogate of IR might play a role in detecting abnormalities of liver function parameters among women. However, PCOS status cannot change the association between IR and liver dysfunction.
Activation of Shh/Smo is sufficient to maintain oligodendrocyte precursor cells in an undifferentiated state and is not necessary for myelin formation and (re)myelination
Authors: Nocera Sonia , Marchena Miguel A. , Fernández‐Gómez Beatriz , Gómez‐Martín Paula , Sánchez‐Jiménez Estefanía , Macías‐Castellano Alba , Laó Yolanda , Cordano Christian , Gómez‐Torres Óscar , Luján Rafael , de Castro Fernando 
Published: May 2024

AbstractMyelination is the terminal step in a complex and precisely timed program that orchestrates the proliferation, migration and differentiation of oligodendroglial cells. It is thought that Sonic Hedgehog (Shh) acting on Smoothened (Smo) participates in regulating this process, but that these effects are highly context dependent. Here, we investigate oligodendroglial development and remyelination from three specific transgenic lines: NG2‐CreERT2 (control), Smofl/fl/NG2‐CreERT2 (loss of function), and SmoM2/NG2‐CreERT2 (gain of function), as well as pharmacological manipulation that enhance or inhibit the Smo pathway (Smoothened Agonist (SAG) or cyclopamine treatment, respectively). To explore the effects of Shh/Smo on differentiation and myelination in vivo, we developed a highly quantifiable model by transplanting oligodendrocyte precursor cells (OPCs) in the retina. We find that myelination is greatly enhanced upon cyclopamine treatment and hypothesize that Shh/Smo could promote OPC proliferation to subsequently inhibit differentiation. Consistent with this hypothesis, we find that the genetic activation of Smo significantly increased numbers of OPCs and decreased oligodendrocyte differentiation when we examined the corpus callosum during development and after cuprizone demyelination and remyelination. However, upon loss of function with the conditional ablation of Smo, myelination in the same scenarios are unchanged. Taken together, our present findings suggest that the Shh pathway is sufficient to maintain OPCs in an undifferentiated state, but is not necessary for myelination and remyelination.
Transformational leadership and follower performance: Relational and motivational bases of leader behaviors
Authors: Erdurmazli Eser 
Published: May 2024

AbstractBased on criticisms and recommendations in the literature made particularly in the last decade, this study focuses on the basic assumptions of transformational leadership (TL) theory such as “follower transformation,” “conceptual differences between the sub‐dimensions of TL” and “performance beyond expectations.” In this regard, it hypothesizes that while individualized consideration and idealized influence sub‐dimensions of TL affect followers' perceptions about the quality of their relationships with their leaders, the inspirational motivation and intellectual stimulation sub‐dimensions are mostly motivational (i.e., person‐organization fit and self‐efficacy), and that these sub‐dimensions enhance follower performance (i.e., organizational citizenship behaviors and task performance) through these specified mechanisms. It also hypothesizes that the quality of leader‐member exchanges moderates the influences of the motivational aspects of TL on follower performance. These hypotheses were tested and confirmed by analyzing the data from 222 leader–follower pairs from the private security sector. Theoretical and practical implications of the findings are discussed and suggestions for future research are provided. This article hopes to motivate future studies to clarify the TL theory and to further support its development.
EEF1D stabilized by SRSF9 promotes colorectal cancer via enhancing the proliferation and metastasis
Authors: Wang Rui , Lv Chi , Li Donghao , Song Yutong , Yan Zhaopeng 
Published: May 2024

AbstractColorectal cancer (CRC) is the third most common cancer and causes high mortality worldwide. Although CRC has been studied widely, the molecular mechanism is not completely known. Eukaryotic translation elongation factor 1 delta (EEF1D) participates in the progression of various tumors, however, the effect of EEF1D on CRC remains unclear. Here, we aimed to identify the potential mechanism of EEF1D in CRC. The expression levels of EEF1D were assessed in CRC samples. Functional analysis of EEF1D in CRC was detected in vitro and in vivo. The regulatory mechanism of EEF1D was identified with RNA immunoprecipitation, RNA pull‐down assay, and proteomics analysis. Our findings confirmed that EEF1D was upregulated in human CRC tissues. Functionally, EEF1D overexpression accelerated cell proliferation and metastasis, whereas EEF1D knockdown inhibited cell proliferation and metastasis both in vitro and in vivo CRC models. Furthermore, we showed that EEF1D was upregulated by SRSF9 via binding to 3′UTR of EEF1D mRNA. EEF1D knockdown reversed the malignant phenotype induced by SRSF9 overexpression. These findings demonstrated that EEF1D promotes CRC progression, and EEF1D may be a molecular target against CRC.
Effectiveness of secukinumab for overlapping hidradenitis suppurativa and ankylosing spondylitis
Authors: AlAfeefi Mariam , Aladawi Meera 
Published: May 2024

AbstractHidradenitis suppurativa is a chronic inflammatory disease of the hair follicle that affects the axillary and gluteal regions. Hidradenitis can coincide with other inflammatory diseases, such as ankylosing spondylitis. We present a patient suffering from an overlap of both conditions, who had a rapid improvement with secukinumab.
Unicompartmental osteoarthritis: High survival rate with a combined mechanical and biological salvage approach as alternative to metal resurfacing: Results at minimum 10 years of follow‐up
Authors: Solaro Luca , Andriolo Luca , Di Martino Alessandro , Grassi Alberto , Zaffagnini Stefano , Filardo Giuseppe 
Published: May 2024

AbstractPurposeThe aim of this study was to prospectively evaluate the long‐term clinical results and failure rate of patients treated with complex salvage procedures using a combined mechanical and biological approach to address unicompartmental knee osteoarthritis (OA) and postpone the need for joint replacement.MethodsThirty‐nine patients (40.3 ± 10.9 years old) affected by unicompartmental OA (Kellgren–Lawrence 3) in stable joints underwent a personalized surgical treatment depending on the specific requirements of the affected compartment, including high tibial osteotomy, osteochondral scaffold, meniscal scaffold and meniscal allograft transplantation. Patients were evaluated with the International Knee Documentation Committee (IKDC), Visual Analogue Scale (VAS) and Tegner scores before surgery, at 3 years and a minimum of 10 years of follow‐up.ResultsA significant improvement was observed over time in all scores but worsened at the final follow‐up. The IKDC subjective score improved from 46.9 ± 16.2 to 79.8 ± 16.4 at 3 years (p < 0.0005) and then decreased to 64.5 ± 21.4 (p = 0.001) at 12 years. A similar trend was confirmed for VAS and Tegner scores. Only two patients subsequently underwent knee arthroplasty, and nine more patients were considered clinical failure, for a cumulative surgical and clinical failure rate of 28.2% at the final follow‐up.ConclusionA personalized, joint‐preserving, combined mechanical and biological approach, addressing alignment as well as meniscal and cartilage lesions, is safe and effective, providing a clinical benefit and delaying the need for arthroplasty in young patients affected by unicompartmental knee OA. At the final evaluation, the clinical improvement decreased, but more than two‐thirds of the patients still benefited from this treatment at a long‐term follow‐up.Level of EvidenceLevel IV case series.