bluuebunny/crossref_metadata_2025_split huggingface dataset:
Beyond Pharmaceuticals: Harnessing the Potential of Plant-based Compounds for Anti-inflammatory Therapy
Authors: Mittal Vishnu , Sharma Anjali 
Published: June 2024

:
A complicated biological reaction of vascular tissues to damaging stimuli like infections,
harmed cells, or irritants is called inflammation. Symptoms include redness, inflamed joints,
stiffness, discomfort in the joints, and loss of joint function. NSAIDs are frequently used to treat
inflammation. Sadly, these drugs raise the possibility of blood clots, which can result in heart attacks
and strokes. Consequently, there is ongoing research focusing on developing potent anti-inflammatory
drugs using natural ingredients. Natural products, due to their diverse chemical composition,
offer a rich source for the development of novel medications. The treatment of various inflammation-
related disorders heavily relies on a natural substance derived from medicinal plants.
The objective of the present study is to assemble information on potential parts of the plants or
phytochemicals derived from medicinal plants used on inflammatory models, employing state-ofthe-
art scientific methodologies. In this study, state-of-the-art scientific methodologies are utilized
to investigate the effects of phytochemicals derived from medicinal plants. Relevant data is collected,
focusing on the examination of these phytochemicals in experimental models of inflammation.
The study aims to collect thorough data on potential plant parts or promising phytochemicals derived
from medicinal plants that have been evaluated using advanced scientific techniques in the
realm of inflammation models. This compilation will offer valuable insights into their potential as
anti-inflammatory agents. The findings have the potential to contribute to the development of new
and improved anti-inflammatory medications with fewer or no adverse effects compared to current
treatments. While many of these studies hold academic interest only a few are accepted into
clinical trials. Numerous phytoconstituents have been identified for exhibiting diverse pharmacological
actions.
Women’s Participation in Cultural Tourism Based Community Empowerment
Authors: Hasdiani Tanisa , Mulyono Sungkowo Edy , Abimbowo Yusuff Olatunji 
Published: June 2024

Kampung Batik is one of the cultural tourism destinations and has been the largest Batik producer in Semarang city since the 18th century. Most of the population consists of women who are actively involved in Batik cultural activities. The research aims to describe the stages, the forms, and the impact of women’s participation in community empowerment. The study was designed with a descriptive qualitative approach involving three female members, including the Tourism Assistance Community of Kampoeng Djadhoel chairman, the Neighborhood Head of Kampung Batik, and the Kampung Batik community. Data were collected through participatory observation, interviews, and documentation. Data validity testing was carried out using triangulation of sources and techniques. The stages of data analysis were data collection, data reduction, data presentation, and conclusion drawing. The results showed that the stages of women’s participation included decision-making, activity implementation, monitoring and evaluation, and utilization of development results. The positive impact of women’s participation is increased employment, income, and skills; the negative effect is the problem arising from Batik waste management. This research can be a reference for the government, society, and women to improve women’s welfare through empowerment.
Process intensification for hydrogen production in protruded reactors with enhanced heat and mass transfer
Authors: Chen Junjie 
Published: June 2024

The present study focuses upon the physics of heat and mass transfer
processes in a protruded millisecond microchannel reactor, wherein a
steam reforming reaction is proceeding and protrusions are used to
improve the transport processes involved. Parametric analysis of the
reactor system is carried out using a three-dimensional numerical model
that is sufficiently detailed to delineate the role of geometric
features and operation conditions in reactor performance. Computational
fluid dynamics analyses are performed under different sets of
circumstances. In analysing the mechanisms involved in the intensified
processes, account is taken of the factors that may influence the
reactor performance. New insights into the physics of the processes are
presented, with recommendations on how to optimize reactor design for
better performance. The results indicate that the flow rates and feed
compositions must be adjusted as needed to maximize production of
hydrogen and minimize pressure drops. Protrusions are very effective in
improving the transport processes involved without greatly impairing
hydraulic performance. Methanol can be converted effectively to hydrogen
due to the successive continuous interruptions in the presence of
hemispherical protrusions. Necessary adjustments to the molar ratio of
steam to methanol can be made to control the maximum reactor temperature
within certain needed limits. Protrusions can be used to improve the
conversion and productivity due to enhanced heat and mass transfer, as
they behave as a baffle to direct flow of the reforming process flow
stream.
Keywords: Operation conditions; Periodic wakes; Methanol
processors; Protruded reactors; Process intensification; Efficient
operation
Molecular dynamics study of thermal rippling phenomena of pristine and functionalised graphene
Authors: Chen Junjie 
Published: June 2024

Little research has been conducted to determine the thermal properties
and phenomena of graphane and fluorographene. A clear understanding of
the thermal problems involved is needed, which may provide a basis for
further research on other material properties. In the present study,
molecular dynamics simulations were performed to investigate the thermal
properties of graphane and fluorographene and especially the phenomena
involved, including thermal fluctuations and bending rigidities.
Furthermore, comparisons of thermal properties and the phenomena
involved were made computationally between pristine and functionalised
graphene. The thermal fluctuations and bending rigidities were
determined at different temperatures. The present study aims to provide
a clear understanding of the thermal problems involved in hydrogenated
and fluorinated graphene. The results indicated that while thermally
excited ripples spontaneously appear in graphene, fully hydrogenated or
fluorinated graphene is substantially unrippled due to their very high
bending rigidities. There is no significant effect of thermal rippling
throughout graphane and fluorographene due to their very high bending
rigidities. However, partially hydrogenated or fluorinated graphene
exhibits strong thermal fluctuations. Graphene behaves differently from
graphane and fluorographene with regard to the dependence of bending
rigidity on temperature. Furthermore, significant out-of-plane
fluctuations may occur in partially fluorinated graphene. Thermal
fluctuations of graphene are more sensitive to temperature than those of
graphane and fluorographene.
Keywords: Thermal properties; Molecular dynamics; Thermal
rippling; Thermal fluctuations; Bending rigidities; Thermal phenomena
Rootzone Soil Moisture Dynamics Using Terrestrial Water-Energy Coupling
Authors: Sehgal Vinit , Mohanty Binayak , Reichle Rolf 
Published: June 2024

A lack of high-density rootzone soil moisture
(θ) observations limits the estimation
of continental-scale, space-time
contiguous θ dynamics. We derive a proxy
of daily θ dynamics ― active
rootzone degree of saturation (S ) ― by
recursive low-pass (LP) filtering of surface soil moisture
(θ) within a terrestrial water-energy
coupling (WEC) framework. We estimate the LP filter parameters and WEC
thresholds for the piecewise-linear coupling between
S and evaporative fraction (EF) at
remote sensing and field scale over Contiguous U.S. We
use θ from Soil Moisture Active-Passive
(SMAP) satellite and 218 in-situ stations, with EF from Moderate
Resolution Imaging Spectroradiometer. The estimated
S shows high validation skill against
SMAP Level-4 estimates and in-situ θ, at
the corresponding scale. The instantaneous hydrologic state
of S vis-à-vis the WEC thresholds is
proposed as a rootzone soil moisture stress index
(SMS) for near-real-time operational agricultural
drought monitoring― demonstrating high agreement with established
drought metrics.
Effect of IBA and NAA on the Rooting and Vegetative Growth of Hardwood Cuttings in Common Fig (Ficus carica L.)
Authors: Nale Rutuja , Sharma Gaurav , Pal Ranjit , Patel R. K. , Sharma Shivali 
Published: June 2024

The present investigation was carried out at Horticultural Nursery of Rani Lakshmi Bai Central Agricultural University (RLBCAU), Jhansi during the year 2021 to study the effect of different levels of IBA and NAA on the rooting and vegetative growth of hard wood cutting in common fig. The experiment was laid out in Completely Randomized Design in eleven treatments with three replications. The treatments comprised of IBA (500, 1000, 1500, 2000, 2500 ppm) and NAA (500, 1000,1500, 2000, 2500 ppm) by quick dip method along with control. The result indicated that IBA (2500 ppm) was found to be best in terms of early sprouting (10.26 days), Sprouted cutting (88.84%), survival % (87.29), number of roots cutting-1(12.35 and 20.86), length of longest root cutting-1 (23.01 cm), length of shoot (12.37 cm and 26.19 cm ), shoot diameter (1.59 cm), number of shoot cutting-1 (1.73 and 2.06) , fresh weight of roots cutting-1 (12.72 g), dry weight of roots cutting-1 (4.75 g) fresh weight of shoot cutting-1 (32.73 g), dry weight of shoot cutting-1 (9.19 g), number of leaves (8.77 and 11.40), leaf size i.e. length and width (14.20 cm and 13.56 cm), fresh weight of plant biomass (45.46 g) and dry weight of plant biomass (13.94 g).
cAMP Content in Mitochondria of Cardiomyocytes in C57bl/6 Mice With B16/F10 Melanoma in the Background of Chronic Neuropathic Pain
Authors: Frantsiyants E. M. , Bandovkina V. A. , Neskubina I. V. , Shikhlyarova A. I. , Kaplieva I. V. , Surikova E. I. , Pogorelova Yu. A. , Cheryarina N. D. , Trepitaki L. K. , Todorov S. S. , Ushakova N. D. , Ishonina O. G. 
Published: June 2024

Aim. To study the effect of malignant tumor growth on level of cAMP in mitochondria of cardiomyocytes in mice with chronic neuropathic pain.Materials and Methods. С57ВL/6 mice (n = 336) have been grouped as follows: intact mice (♂n = 21; ♀n = 21), mice with chronic neuropathic pain (♂n = 21; ♀n = 21), mice with melanoma В16/F10 (♂n=63; ♀n=63), and mice with melanoma В16/ F10 and chronic neuropathic pain (♂n=63; ♀n=63). After 1, 2, and 3 weeks of the melanoma growth, cardiac mitochondria of abovementioned mice have been isolated by the centrifugation with the following measurement of cAMP.Results. Chronic neuropathic pain has induced a 3.6-fold reduction in cAMP in cardiac mitochondria of female mice. In mice with melanoma В16/ F10, cardiac cAMP showed 4-fold average increase from the 2nd week of the tumor growth, while in mice with melanoma В16/F10 and chronic neuropathic pain a 2-4-fold increase in cAMP was recorded as soon as from the 1st week of tumor growth, eventually leading to the depletion of cAMP by the 3rd week of the experiment. Serum cAMP concentration did not correlate with the cAMP level in cardiac mitochondria and was reduced in both males and females.Conclusion. Alterations in cAMP concentration in cardiac mitochondria were gender-specific, as female mice responded to a chronic neuropathic pain without other triggers. In mice with melanoma and chronic neuropathic pain, cAMP level raised significantly earlier than in mice without chronic neuropathic pain, resulting in full cAMP depletion by the 3rd week of the experiment.
SISTEM MONITORING PLTS BERBASIS IOT SEBAGAI MEDIA PEMBELAJARAN
Authors: Waluyo Bakti Dwi , Rahman Sembiring Muhammad Aulia , Sinaga Nelson , Lubis Ali Akbar , Br Tarigan Sintya Verina 
Published: June 2024

Abstrak: Penelitian ini bertujuan untuk mengembangkan sistem monitoring pembangkit listrik tenaga surya (PLTS) berbasis Internet of Things (IoT) sebagai media pembelajaran di Jurusan Pendidikan Teknik Elektro Universitas Negeri Medan. Sistem monitoring ini dinamakan EduSolar, yang dirancang menggunakan kombinasi perangkat keras seperti mikrokontroler Arduino UNO, modul sensor arus, tegangan, daya, intensitas cahaya, serta modul WiFi ESP8266 untuk konektivitas IoT. Sistem EduSolar dapat memantau dan menampilkan parameter-parameter penting PLTS secara real-time melalui antarmuka website. Penelitian ini menggunakan metode pengembangan ADDIE yang terdiri dari tahap analisis, desain, pengembangan, implementasi, dan evaluasi. Hasil validasi ahli media menunjukkan persentase kelayakan 81,28%, sedangkan validasi ahli materi mencapai 80,83%. Uji respon mahasiswa juga menunjukkan bahwa sistem EduSolar dinyatakan "layak" digunakan sebagai media pembelajaran dengan persentase 78,46%. Dengan demikian, sistem monitoring PLTS berbasis IoT yang terintegrasi sebagai media pembelajaran ini terbukti efektif dalam meningkatkan pemahaman mahasiswa tentang teknologi energi surya. Kata Kunci: Sistem Monitoring PLTS, IoT, Media Pembelajaran, Pembelajaran Interaktif, Energi Surya. Abstract: This research aims to develop an Internet of Things (IoT)-based solar power plant (PLTS) monitoring system as a learning media in the Department of Electrical Engineering Education at Medan State University. The monitoring system is called EduSolar, designed using a combination of hardware devices such as the Arduino UNO microcontroller, current, voltage, power, and light intensity sensor modules, as well as the ESP8266 WiFi module for IoT connectivity. The EduSolar system can monitor and display real-time important parameters of the solar power plant through a website interface. This research utilizes the ADDIE development method, which consists of analysis, design, development, implementation, and evaluation stages. The validation results from media experts showed a feasibility percentage of 81.28%, while the validation by subject matter experts reached 80.83%. The student response test also indicated that the EduSolar system was deemed "feasible" as a learning media with a percentage of 78.46%. Therefore, this IoT-based PLTS monitoring system integrated as a learning media has been proven effective in enhancing students' understanding of solar energy technology. Keywords: PLTS Monitoring System, IoT, Learning Media, Interactive Learning, Solar Energy.
Serologic profiling of D variants in donor routine: unveiling the impact on false-negative results and alloimmunization
Authors: Arnoni Carine P. , Vendrame Tatiane A. , Silva Flavia S. , Silva Nayara M. , Cortez Afonso , Latini Flavia , Castilho Lilian 
Published: June 2024

Abstract
The high number of D variants can lead to the unnecessary use of Rh immune globulin, overuse of D− RBC units, and anti-D allommunization. D variant prevalence varies among ethnic groups, and knowledge of the main variants present in a specific population, their behavior in serologic tests, and their impact on clinical practice is crucial to define the best serologic tests for routine use. The present study aimed to explore the serologic profile of D variants and to determine which variants are most associated with false-negative D typing results and alloimmunization. Donor samples were selected in two study periods. During the first period, D typing was performed on a semi-automated instrument in microplates, and weak D tests were conducted in tube or gel tests. In the second period, D typing was carried out using an automated instrument with microplates, and weak D tests were performed in solid phase. Samples from patients typed as D+ with anti-D were also selected. All samples were characterized by molecular testing. A total of 37 RHD variants were identified. Discrepancies and atypical reactivity without anti-D formation were observed in 83.4 percent of the samples, discrepant D typing results between donations were seen in 12.3 percent, and D+ patients with anti-D comprised 4.3 percent. DAR1.2 was the most prevalent variant. Weak D type 38 was responsible for 75 percent of discrepant samples, followed by weak D type 11, predominantly detected by solid phase. Among the D variants related to alloimmunization, DIVa was the most prevalent, which was not recognized by serologic testing; the same was true for DIIIc. The results highlight the importance of selecting tests for donor screening capable of detecting weak D types 38 and 11, especially in populations where these variants are more prevalent. In pre-transfusion testing, it is crucial that D typing reagents demonstrate weak reactivity with DAR variants; having a serologic strategy to recognize DIVa and DIIIc is also valuable.
When and why is red blood cell genotyping applicable in transfusion medicine: a systematic review of the literature
Authors: Akinbolaji Thompson J. 
Published: June 2024

Abstract
This review aims to provide a better understanding of when and why red blood cell (RBC) genotyping is applicable in transfusion medicine. Articles published within the last 8 years in peer-reviewed journals were reviewed in a systematic manner. RBC genotyping has many applications in transfusion medicine including predicting a patient’s antigen profile when serologic methods cannot be used, such as in a recently transfused patient, in the presence of autoantibody, or when serologic reagents are not available. RBC genotyping is used in prenatal care to determine zygosity and guide the administration of Rh immune globulin in pregnant women to prevent hemolytic disease of the fetus and newborn. In donor testing, RBC genotyping is used for resolving ABO/D discrepancies for better donor retention or for identifying donors negative for high-prevalence antigens to increase blood availability and compatibility for patients requiring rare blood. RBC genotyping is helpful to immunohematology reference laboratory staff performing complex antibody workups and is recommended for determining the antigen profiles of patients and prospective donors for accurate matching for C, E, and K in multiply transfused patients. Such testing is also used to determine patients or donors with variant alleles in the Rh blood group system. Information from this testing aides in complex antibody identification as well as sourcing rare allele-matched RBC units. While RBC genotyping is useful in transfusion medicine, there are limitations to its implementation in transfusion services, including test availability, turn-around time, and cost.
A national survey of current immunohematologic testing practices for the diagnosis of autoimmune hemolytic anemia in India
Authors: Das Sudipta S. , Das Soumya , Agrawal Soma , Shastry Shamee , Shenoy Veena , Datta Suvro S. 
Published: June 2024

Abstract
Autoimmune hemolytic anemia (AIHA) is a common term for several disorders that differ from one another in terms of etiology, pathogenesis, clinical features, and treatment. Management of patients with AIHA has become increasingly evidence-based in recent years. While this development has resulted in therapeutic improvements, it also carries increased requirements for optimal diagnosis using more advanced laboratory tests. Unfortunately, limited data are available from developing countries regarding the testing and transfusion management of patients with AIHA. The main objective of this survey was to explore the current immunohematologic testing practices for the diagnosis of AIHA in India. This online survey consisted of 30 questions, covering the place of work, the number of AIHA cases encountered in the 3 preceding years, testing method(s), transfusion management, and so forth. Individuals representing 89 laboratories completed the survey; only 78 of which responded that AIHA testing was performed in their facility’s laboratory. The majority of respondents agreed that the most commonly affected age-group comprised individuals of older than 20 years, with a female preponderance. Regarding transfusion management, respondents indicated that transfusion with “best-match” red blood cell units remains the most common practice. Column-agglutination technology is used by 92 percent of respondents as the primary testing method. Although a monospecific direct antiglobulin test is available at 73 percent of the sites, most of them have limited access to other resources that could diagnose cold or mixed AIHA. Merely 49 percent of responding laboratories have the resources to perform adsorption studies for the detection of alloantibodies. Furthermore, three-cell antibody screening reagents are unavailable at 32 percent of laboratories. In 72 percent of centers, clinical hematologists would prefer to consult a transfusion medicine specialist before administering treatment to AIHA patients. There is unanimous agreement regarding the need for a national registry. The survey data indicate wide variability in testing practices for patients with AIHA in India. Future studies are needed to focus on the feasibility and cost-effectiveness of different testing strategies for developing countries.
How anti-c in a D– patient prompted lifesaving work between a transfusion service and a blood center reference laboratory
Authors: Patch Gavin , Maurer Joan , Sendilnathan Arun , Leak Christine , Nartowicz Elizabeth , Kavitsky Victoria , Facey Dexter , Nance Sandra T. , Keller Margaret A. 
Published: June 2024

Abstract
This case report showcases an extraordinary collaboration to support the transfusion needs of a patient with a rare phenotype and long-standing anemia due to gastrointestinal bleeding. This report describes the Immunohematology Reference Laboratory testing and logistics of rare blood provision over an 11-year period, as well as a summary of the hematologic, gastroenterologic, and surgical interventions. This case illustrates how a strong collaboration among the clinical team, laboratory, blood center, and the rare donor community facilitated successful management of this patient’s anemia until the patient could receive life-changing treatment.
Morphophysiological Parameters and Leek Seed Production Depending on Fulvohumin Treatment and Date of Planting Seedlings
Authors: Slobodianyk Halyna , Ternavskyi Andrii , Smetanska Iryna , Krykunov Ihor , Voievoda Liliia , Hnatiuk Nataliia , Sukhanov Sviatoslav , Boroday Vira , Helfert Julia , Voitsekhivskyi Volodymyr 
Published: June 2024

Abstract
Producing leek seeds without replanting one-year-old plants is cheaper and more practical, but can be risky in climates with cold winters. This research aimed to assess whether accelerating the planting of seedlings and using Fulvohumin fertilizer, containing, among others, humic acids can make such production less risky. Three dates were used for planting leek seedlings: April 10, April 25, and May 10. Fulvohumin was used presowing, foliarly, and both. Both factors significantly improved seed production. The best results were obtained at the earliest planting date, as the plants were strong and best prepared for the generative phase and the frost period. Fulvohumin significantly improved growth and development parameters, mainly when used before sowing and as foliar application. In the best combination, with two applications of fertilizers, the seed yield increased by 39%, compared to the control (without Fulvohumin fertilization), and the seed yield of plants planted on April 10 was 17% higher compared to plants planted on April 25 (considered as standard) and 39% higher than those planted on May 10. Seed yield varied in the three subsequent years of the study, but each year, the planting date and Fulvohumin had a similar effect on seed yield.