bluuebunny/crossref_metadata_2025_split huggingface dataset:
Oral health disorders among visually impaired children in South Asian countries: a systematic review
Authors: Mehta Vini , Selvaraj Siddharthan , Tripathy Snehasish , Mishra Neeta , Negi Sapna , Mathur Ankita , Tabnjh Abedelmalek Kalefh 
Published: February 2025

Background and aimDespite the convergence of visual impairment and poor oral health among children, there is a scarcity of data on the common oral health disorders and their prevalence among children with visual impairments in South Asia. The purpose of this systematic review is to synthesize the existing literature on oral health diseases in visually impaired children in South Asia.MethodsAn exhaustive literature search was carried out in PubMed-MEDLINE, Scopus, Embase and Google Scholar from inception till 31st December, 2024. We included studies if they fulfilled the following criteria: visually impaired children (aged &lt;18 years); assessment using dental examination; children with no other impairment from South Asian regions. Due to the high variability across age groups within the target population, we have synthesized and presented the data in a narrative format.ResultsThe search across databases yielded a total of 1,681 studies, out of which 9 studies were included. The prevalence of dental caries was reported ranging from 40% to 98.5%, and dental trauma ranged from 4.62% to 44.28%. High prevalence of malocclusion and gingivitis has also been reported. Quality assessment showed that three studies had medium risk of bias and remaining had a low risk of bias.ConclusionIn the South Asian region, it is crucial to make special needs dentistry widely accessible, provide caregivers with sufficient dental health information, and ensure dentists receive specialized training to enhance the effectiveness, comfort, and satisfaction of treatment.Systematic Review Registrationhttps://www.crd.york.ac.uk/prospero/display_record.php?RecordID=582083, PROSPERO (CRD42024582083).
Past and future trends in swiss snow cover: multi-decades analysis using the snow observation from space algorithm
Authors: Poussin Charlotte , Timoner Pablo , Peduzzi Pascal , Giuliani Gregory 
Published: February 2025

Despite the large availability of satellite and in-situ data on snow cover in the Northern Hemisphere, long-term assessments at an adequate resolution to capture the complexities of mountainous terrains remain limited, particularly for countries like Switzerland. This study addresses this gap by employing two products—the monthly NDSI (Normalized Difference Snow Index) and snow cover products—derived from the Snow Observation from Space (SOfS) algorithm to monitor snow cover dynamics across Switzerland over the past 37 years. The pixel-wise analysis reveals significant negative trends in the monthly NDSI across all seasons, with the most pronounced decreases at low to mid-elevations, particularly in winter and spring (e.g., a 50% reduction in NDSI for pixels showing positive significative trends in winter below 1,000 m, and a 43% reduction in spring between 1,000 and 2,000 m). Similarly, snow cover area has declined significantly, with reductions of −13% to −15% in spring for the transitional zones between 1,000–1,500 m and 1,500–2,000 m. Furthermore, the monthly NDSI values are more strongly influenced by temperature than precipitation, especially at lower altitudes. To estimate trends in snow cover for the 21st century, we modelled the relationship between snow presence and two climatic variables (temperature and precipitation) using a binomial generalized linear mixed model (GLMM). In the context of climate change, projections under various greenhouse gas emission scenarios suggest further declines in snow cover by the end of the century. Even with moderate climate action (RCP 2.6), snow-free areas could expand by 22% at lower elevations by 2100. Under the more extreme scenario (RCP 8.5), snow-free regions could increase by over 43%, with significant impacts during the transitional months of April and May. The SOfS algorithm, developed within the Swiss Data Cube, provides valuable insights into snow cover dynamics across Switzerland. Complementing in-situ observations, this innovative approach is essential for assessing snow cover changes and guiding adaptation strategies in a country where snow is not only an environmental indicator but also a cultural and economic asset.
Linkage of jockey falls and injuries with racehorse injuries and fatalities in Thoroughbred flat racing in Victoria, Australia
Authors: Morrice-West Ashleigh V. , Thomas Megan , Wong Adelene S. M. , Flash Meredith , Whitton R. Chris , Hitchens Peta L. 
Published: February 2025

IntroductionRacehorse and jockey incidents on race-days frequently occur together, yet risk factors for their occurrence have historically been investigated separately. Consideration of both horses and humans in tandem is required for a One Health approach to risk reduction. Our objectives were to therefore identify modifiable risk factors for adverse outcomes that are common or conflicting to both horses and their jockeys in Thoroughbred racing.MethodsAustralian Single National System records for the 2004/05 to 2018/19 flat racing season were merged with the corresponding Australian Racing Incident Database records. Incidence rate ratios (IRR) with 95% confidence intervals (CI) were estimated for the outcomes of racehorse musculoskeletal injury (MSI), racehorse fatality, jockey falls and jockey injury using Poisson regression. Horse-level, race-level, jockey-level and trainer-level factors associated with each adverse outcome during or post-race were identified using multivariable logistic regression.ResultsThe incidence of MSI was 21.21 (20.84, 21.59), racehorse fatalities 0.55 (0.50, 0.61), jockey falls was 3.01 (2.80, 3.24), and jockey injuries 1.79 (1.63, 1.97) per 1000 flat race starts. There was a decrease in racehorse MSI and jockey falls over the study period but no change in racehorse fatality or jockey injury incidence. In multivariable analysis, longer race distances and higher caliber races were associated with horse (p &lt; 0.01), but not jockey, incidents. Firmer turf surfaces were associated with greater risk of both horse incidents and jockey falls (p &lt; 0.05). Racehorses that were of older age at their first start, and/or had prior race-day injuries had a greater risk of injury and fatality (p &lt; 0.001, p &lt; 0.01, respectively). The most prominent risk factor for jockey fall or injury was a racehorse incident, although overall contributing to a relatively small proportion; 8.6% (n = 42/489) of jockey falls and 15.3% (n = 24/147) of injuries. Jockeys with fewer career starts were at greater risk of falling, and those with a higher percentage of last place finishing positions were at greater risk of injury (p &lt; 0.001).DiscussionAs there were no conflicting risk factors identified between racehorse and jockey injury, policies aimed at reducing horse injury risk are also expected to benefit their riders.
Study Regarding the Simulation of the Flow of a Fluid Through Pipes Intended for the Domestic Water Network, and the Causes of Their Degradation
Authors: TUDOR Beatrice Daniela , STERIAN Dumitra 
Published: February 2025

A public water supply and sanitation system refers to the infrastructure and services needed to provide drinking water, and to collect and treat wastewater, in a community or geographic area. It has the role of ensuring access to safe drinking water and correctly managing liquid waste generated by the population and industry.The paper makes a simulation, with the help of the SolidWorks program, of the flow of liquids through the pipes, and analyses the causes of the degradation of the pipes, intended for the domestic water network.
An Intelligent System for Temperature Body Monitoring Using Arduino Platform
Authors: MARIN Mihaela , BORŞAN Alexandra , BURUIANĂ Laura-Daniela , MARIN Florin-Bogdan 
Published: February 2025

An accurate measurement of the body temperature is a critical component in monitoring the human health, with applications ranging from clinical diagnostics to wearable health monitoring systems. Using the Arduino platform for body temperature monitoring provides an affordable, customizable and efficient solution for a wide range of applications, from personal care to patient monitoring in hospitals, this type of device can significantly contribute to improving health and safety. The MLX90614 sensor is an innovative and efficient solution for temperature measurement in the medical engineering field. With its outstanding accuracy and adaptability in measuring body temperature and medical devices, this deviceasserts itself as an indispensable tool in monitoring and managing the health of patients and medical devices in a variety of clinical and treatment settings.
Design and Manufacturing of a Custom Guitar Amplifier: Optimizing Materials for Acoustic Performance and Durability
Authors: KUBASZKY Andrada Elena , BRĂILEANU Patricia Isabela 
Published: February 2025

The project sought to design a guitar amplifier that would easily integrate into the decor of an apartment, imitating a piece of furniture. The design aims to create an aesthetic appearance that fits harmoniously in different types of homes, eliminating the need to bend down to adjust volume, tone, etc. The amplifier was built from a wooden case, with an accessory storage system in a lower drawer, and the functionality was achieved by integrating an Arduino board and a PCB circuit to implement the audio effects. The study details the stages of designing the amplifier prototype, including making the printed circuit board and processing the audio signal in four distinct stages: analogue signal amplification, digitalprocessing by Arduino, signal output stage, and power supply. The project also includes the careful design of the amplifier components, using quality materials such as spruce panel to ensure superior acoustics. The result demonstrates the complexity and innovation in the field of musical equipment, combining aesthetic with technical aspects.
A Comparative Study Regarding the Performance of Corpuls 3 and Zoll Defibrillators
Authors: MARIN Mihaela , ILIE Florin Marian , MARIN Florin Bogdan 
Published: February 2025

The purpose of this paper is to provide a detailed and accessible overview of the Corpuls 3 and Zoll defibrillators, highlighting their features, functionalities and advantages in the monitoring and treatment of patients in emergency and intensive care settings. The comparison was based on seven main criteria: modularity, design, CPR capacity, performance, vital parameters monitoring, monitoring screens and maintenance costs.
The Recovery of Vegetal Waste in the form of Home-Composting
Authors: ȘERBAN Anca , LEOPA Adrian 
Published: February 2025

Composting the vegetable waste is an ecological alternative to their treatment by incineration or storage on landfills. The recovery of vegetable waste for obtaining compost is a beneficial method both by keeping a clean environment and enriching the soil. The vegetable waste decomposes and leave its intake nutrient in the soil for plants and other crops growth. The paper includes the chemical analysis and testing results of the compost obtained with garden vegetable waste (dried leaves, branches, bark, stems, flowers and herbs).
Factores Asociados con el Abandono del Tratamiento Insulínico en Pacientes con Diabetes
Authors: Jimeno Figueroa Juan Gerardo , Rugerio Ramos Marina , Ramos Durán Jorge Daniel , Flores Zamora Misael , Peña Brindiz Luis Enrique 
Published: February 2025

Introducción. La diabetes mellitus tipo II afecta a millones de adultos y se asocia al 11.3% de muertes a nivel mundial en personas de 20 a 79 años. El control de la DM II es deficiente debido a la baja adherencia insulínica terapéutica en México. Objetivo: Analizar los factores de riesgo asociados con el abandono del tratamiento insulínico en pacientes con diabetes. Metodología: Descriptivo, prospectivo, transversal, observacional, unicentrico, ambos sexos a partir de 18 años, se utilizó el cuestionario Morisky Green para medir la adherencia terapéutica compuesto de 4 items con respuestas dicotomías y 3 niveles de adherencia: baja, media y alta. Para el análisis de datos se utilizó estadística descriptiva: frecuencias y porcentajes. Inferencial con prueba chi cuadrada para variables de asociación. Resultados: Total 140 participantes, 49% fueron mujeres y 51% fueron hombres, las comorbilidades que con más frecuencia se identificaron fue la hipertensión con 48% y obesidad con 31%. Los factores de riesgo que con mayor frecuencia se hallaron fue la hipoglucemia después del tratamiento insulínico 19%, y la polifarmacia, 19%. Conclusiones: Encontramos que existe una asociación estadísticamente significativa respecto a la presencia de más o 3 factores de riesgo con el abandono de insulina.
Starburst Galaxies in Their Last Billion Years: An Hδ Absorption Line Selected Sample
Authors: Wu Shumei , Huang Jia-Sheng , Cheng Cheng , Dai Y. Sophia 
Published: February 2025

Abstract
In this paper, we focus on the study of starburst galaxies in their final billion years. Our galaxy selection is based solely on the presence of the Hδ absorption line, which permits the later evolution of starburst galaxies to be traced, coinciding with the emergence of A-type stars in these galaxies. We propose a novel method that utilizes star formation rate and UVJ colors to classify galaxies in the sample, and use the spectral features to mark their stages of evolution. Our in-depth analysis of the Mg ii line indicates the substantial increase in the number of F- and G-type stars when a galaxy evolves from star-forming to quiescent phase. Furthermore, we identify active galactic nuclei in this sample to explore their roles in the later stage of the star formation history of galaxies.
“Je te salue Vieil Océan”: Images of the Sea in Three Caribbean Women’s Texts (Jamaica Kincaid’s At the Bottom of the River, Grace Nichols’s I Have Crossed an Ocean and Olive Senior’s Hurricane Watch)
Authors: Montoriol Salomé 
Published: February 2025

Résumé du mémoire de master lauréat ex-aequo du prix de la SAIT (Société Angliciste : Arts, Images, Textes), société savante à laquelle est adossée la revue Polysèmes.
Illustration as Transmission: Leslie Saalburg and The Ambassadors
Authors: Leroy Maxime 
Published: February 2025

L’article porte sur les illustrations de Leslie Saalburg réalisées au début des années 1960 pour Les Ambassadeurs de Henry James. Saalburg était un illustrateur reconnu qui travaillait pour des magazines consacrés à la mode, aux voyages ou aux automobiles. Cette commande de The Limited Editions Club semble avoir été sa seule contribution à l’illustration littéraire. La première partie de l’article montre comment les aquarelles de Saalburg empruntent à l’illustration commerciale et reflètent ses idées conservatrices sur l’élégance vestimentaire, dans le contexte d’une nostalgie pour l’époque édouardienne durant les années 1960. En lien avec la place centrale du vêtement, la deuxième partie compare la façon dont les illustrations et le texte de James mettent en scène le regard de Strether, protagoniste et focalisateur du récit, dans son rapport à la fois fétichiste et magique à certains personnages féminins. Il est montré qu’en raison du parti pris conservateur de Saalburg, les illustrations ignorent le concept de formes évolutives de transmission sociale à l’œuvre dans le roman. La troisième partie prolonge cette analyse en montrant la dimension interpictoriale de certaines planches, et en s’appuyant sur la notion de « façons de voir » de Charles Goodwin. Elle se termine par l’idée que l’échange de regards dans les illustrations, confiné aux interactions entre individus d’un même milieu, contourne la représentation jamesienne des tensions entre communautés sociales ou épistémiques opposées.
Penile metastasis from colon cancer with BRAFV600E mutation treated with BRAF/MEK-targeted therapy plus cetuximab: A case report
Authors: Wu Jun-Chen , Cheng Hua-Xi , Lan Qiu-Sheng , Xu He-Yang , Zeng Yu-Jie , Lai Wei , Chu Zhong-Hua 
Published: February 2025

BACKGROUND
The incidence of colon cancer has been progressively increasing over time, whereas penile metastasis of colon cancer has remained exceedingly uncommon. Since the prognosis for colon cancer with BRAF V600E mutation is relatively unfavorable, further exploration and investigation are still required to develop treatment strategies for such rare cases.
CASE SUMMARY
About one year after surgery and chemotherapy, a 50-year-old patient with sigmoid colon cancer developed a mass at the base of the patient's penis, accompanied by severe tenderness and pain during urination. With disease progression, multiple metastatic nodules also emerged in other regions of the penis, including the coronal sulcus. The nodules located in the coronal sulcus were excised for histopathological examination. The histopathological findings revealed that the nodules were metastases originating from the sigmoid colon cancer, with a BRAF V600E mutation detected. This prompted a modification of the therapy regimen of cetuximab, dabrafenib and trametinib, which effectively held back the progression of penile metastasis in the patient.
CONCLUSION
Combining the BRAF/MEK-targeted therapy with cetuximab demonstrates a favorable therapeutic response in BRAF V600E-mutated colon cancer with penile metastasis.
Mapping the landscape of gastric cancer immunotherapy: Bibliometric insights into advances and hotspots
Authors: Yuan Zhen , Wang Jing-Hang , Cui Hao , Wang Shu-Yuan , Wei Bo , Cui Jian-Xin 
Published: February 2025

BACKGROUND
Immunotherapy has surfaced as a promising therapeutic modality for gastric cancer (GC). A comprehensive review of advancements, current status, and research trends in GC immunotherapy is essential to inform future investigative efforts.
AIM
To delineate the trends, advancements, and focal points in immunotherapy for GC.
METHODS
We performed a bibliometric analysis of 2906 articles in English concerning GC immunotherapy published from 2000 to December 20, 2023, indexed in the Web of Science Core Collection. Data analysis and visualization were facilitated by CiteSpace (6.1.6R), VOSviewer v.1.6.17, and GraphPad Prism v8.0.2.
RESULTS
There has been an increase in the annual publication rate of GC immunotherapy research. China leads in publication volume, while the United States demonstrates the highest citation impact. Fudan University is notable for its citation frequency and publication output. Co-citation analysis and keyword frequency revealed and highlighted a focus on GC prognosis, the tumor microenvironment (TME), and integrative immunotherapy with targeted therapy. Emerging research areas include gastroesophageal junction cancer, adoptive immunotherapy, and the role of Treg cell in immunotherapy.
CONCLUSION
GC immunotherapy research is an expanding field attracting considerable scientific interest. With the clinical adoption of immunotherapy in GC, the primary goals are to enhance treatment efficacy and patient outcomes. Unlike hematological malignancies, GC's solid TME presents distinct immunological challenges that may attenuate the cytotoxic effects of immune cells on cancer cells. For instance, although CAR-T therapy is effective in hematological malignancies, it has underperformed in GC settings. Current research is centered on overcoming immunosuppression within the TME, with a focus on combinations of targeted therapy, adoptive immunotherapy, Treg cell dynamics, and precise prognosis prediction in immunotherapy. Additionally, immunotherapy's role in treating gastroesophageal junction cancer has become a novel research focus.
Increased risk of colorectal cancer in young males with higher cardiovascular risk: A nationwide population-based cohort study
Authors: Song Ji Hyun , Choi Su-Yeon , Kim Young Sun , Yang Sun Young , Han Kyung-Do 
Published: February 2025

BACKGROUND
Although the link between cardiovascular disease (CVD) and various cancers is well-established, the relationship between CVD risk and colorectal cancer (CRC) remains underexplored.
AIM
To elucidate the relationship between CVD risk scores and CRC incidence.
METHODS
In this population-based cohort study, participants from the 2009 National Health Checkup were followed-up until 2020. The cardiovascular (CV) risk score was calculated as the sum of risk factors (age, family history of coronary artery disease, hypertension, smoking status, and high-density lipoprotein levels) with high-density lipoprotein (≥ 60 mg/dL) reducing the risk score by one. The primary outcome was incidence of newly diagnosed CRC.
RESULTS
Among 2526628 individuals, 30329 developed CRC during a mean follow-up of 10.1 years. Categorized by CV risk scores (0, 1, 2, and ≥ 3). CRC risk increased with higher CV risk scores after adjusting for covariates [(hazard ratio = 1.155, 95% confidence interval: 1.107-1.205) in risk score ≥ 3, P < 0.001]. This association was exclusively observed in males, most notably in the younger cohort (< 50 years) and was more pronounced in individuals not using statins. Moreover, even in participants without diabetes, a higher CV risk was associated with an increased CRC risk.
CONCLUSION
Increased CV risk scores were significantly associated with higher CRC risk, especially among males, younger populations, and non-statin users. Thus, males with a higher CV risk score, even at a younger age, are recommended to control their risk factors and undergo individualized CRC screening.
To investigate the effect and mechanism of tetrahydrocurcumin on hepatocellular carcinoma based on phosphoinositide 3-kinases/AKT signaling pathway
Authors: Bao Zhuo-Cong , Liu Zhao-Dong , Zhang Ye , Dai Hui-Jun , Jia Hui , Ren Fu , Li Ning , Zhao Lu , Wang Yi-Wei , Lv Shang-Yu , Zhang Yan 
Published: February 2025

BACKGROUND
Liver cancer has a high incidence and mortality worldwide, especially in China. Herein, we investigated the therapeutic effect and mechanism of tetrahydrocurcumin against hepatocellular carcinoma (HCC), with a focus on the of phosphoinositide 3-kinases (PI3K)/AKT signaling pathway.
AIM
To investigate the effects and mechanism of tetrahydrocurcumin in HCC cell lines HepG2 and Huh7.
METHODS
Using Metascape, we analyzed the potential targets of tetrahydrocurcumin in HCC. Molecular docking validation was performed using SYBYL2.0. Cell Counting Kit-8, wound healing, and transwell assays were performed to evaluate the effects of tetrahydrocurcumin on HepG2 and Huh7 cell migration, invasion, and apoptosis. The expression of PI3K/AKT signaling pathway-related proteins was detected by western blotting.
RESULTS
Network pharmacology and molecular docking showed that tetrahydrocurcumin has high binding affinity for phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha. In vitro experiments demonstrated that tetrahydrocurcumin suppressed the migration and invasion of liver cancer cells, promoted their apoptosis, and downregulated the expression of p-PI3K, p-AKT, and B cell leukemia/lymphoma 2, while upregulating caspase-3, p53, and B cell leukemia/lymphoma 2 associated X.
CONCLUSION
In summary, tetrahydrocurcumin suppresses PI3K/AKT signaling, promotes apoptosis, and prevents the migration and invasion of liver cancer cells.