bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of Eutectic Mixture of Local Anesthetics on Pain Perception During Scaling by Ultrasonic or Hand Instruments: A Masked Randomized Controlled Trial
Authors: Chung Jae‐Eun , Koh Sang‐A , Kim Tae‐Il , Seol Yang‐Jo , Lee Yong‐Moo , Ku Young , Rhyu In‐Chul , Chung Chong‐Pyoung , Koo Ki‐Tae 
Published: August 2010

Background: The aims of this study are to evaluate the efficacy of a eutectic mixture of local anesthetic (EMLA) cream on pain perception during scaling and to compare the intensities of pain provoked by hand and ultrasonic instruments.Methods: Forty subjects with chronic gingivitis or periodontitis were enrolled in the study. In this randomized, split‐mouth, controlled, masked clinical trial, each of the four quadrants in subjects was randomly assigned to receive one of the following protocols: scaling with an ultrasonic scaler with or without the application of the EMLA cream or scaling with a Gracey curet with or without the application of the EMLA cream. Pain levels after each quadrant of scaling were assessed with a visual analog scale (VAS; 0 to 100 mm) and verbal rating score (VRS; 0 to 4). All subjects were recalled to detect any complications after 24 hours.Results: The mean VAS and VRS when EMLA cream was applied (18.39 ± 14.47 mm and 0.95 ± 0.69) were significantly lower (P <0.001 for VAS and VRS) compared to when EMLA cream was not used (26.54 ± 16.46 mm and 1.30 ± 0.75). The mean VAS and VRS of the ultrasonic scaler group (20.43 ± 16.40 mm and 0.98 ± 0.76) were significantly lower (P = 0.024 for VAS; P = 0.003 for VRS) than those of the Gracey curet group (24.50 ± 15.17 mm and 1.28 ± 0.69). None of the subjects showed adverse effects after EMLA‐cream application.Conclusion: Although most patients experienced limited pain during scaling, a significant reduction of pain is achieved by using EMLA cream and ultrasonic scaler.
Relation between utero‐placental and feto‐placental circulations: a longitudinal study
Authors: Flo Kari , Wilsgaard Tom , Acharya Ganesh 
Published: August 2010

AbstractObjective. To explore the relation between total utero‐placental (TQuta) and feto‐placental (Quv) blood flows and establish longitudinal reference ranges for the TQuta/Quv ratio and the mean uterine artery and umbilical artery pulsatility (UtaPI/UAPI) and resistance index (UtaRI/UARI) ratios. Design. Prospective longitudinal observational study. Setting. University hospital in Norway. Population. Fifty‐three low‐risk pregnant women. Methods. Uterine artery and umbilical vein blood flow was measured using Doppler ultrasonography at 4‐weekly intervals from 22+0 to 39+6 weeks of gestation. Main outcome measures. Ratios between utero‐placental and feto‐placental volume blood flows and between indices of uterine and umbilical artery impedance. Results. The TQuta/Quv ratio had a significant association with the gestational age (p < 0.00001) and decreased with advancing gestation during the second half of pregnancy. The mean UtaPI/UAPI (p = 0.094) and mean UtaRI/UARI (p = 0.323) ratios were not significantly associated with gestational age and remained relatively constant. There was no significant association between TQuta and Quv (p = 0.72), mean UtaPI and UAPI (p = 0.56), or mean UtaRI and UARI (p = 0.57). Conclusion. The gestational‐age‐related changes in the utero‐placental and feto‐placental circulations do not appear to be affected by each other under physiological conditions. We have established longitudinal reference ranges for the utero‐placental and feto‐placental blood flow and impedance ratios during the second half of pregnancy.
MRI Evaluation of Anterolateral Soft Tissue Impingement of the Ankle
Authors: Ferkel Richard D. , Tyorkin Max , Applegate Gregory R. , Heinen Gregory T. 
Published: August 2010

Background: The usefulness of magnetic resonance imaging (MRI) has been questioned in evaluating patients with chronic ankle sprain pain. The purpose of this study was to determine the effectiveness and reliability of routine MR imaging in the diagnosis of anterolateral soft tissue impingement. Materials and Methods: Inclusion criteria required that the MR examinations be performed by the same musculoskeletal radiologist after the most recent scanner upgrade and using a dedicated ankle/hindfoot coil. The surgical and MRI reports of 24 patients who had an arthroscopic diagnosis of anterolateral soft tissue impingement of the ankle were tabulated and categorized. Unlike previous studies, sagittal T1 and Short Tau Inversion Recovery (STIR) images were used primarily in the diagnosis of these lesions. Results: Using this technique, we report a 78.9% accuracy in diagnosis, a sensitivity of 83.3% and a specificity of 78.6%. Fifty-eight percent of patients had an associated diagnosis, which in 33% of patients altered our surgical plan. Conclusion: Although not indicated in all cases of anterolateral ankle impingement, we advocate the use of MR imaging in complicated clinical presentations where the exclusion of additional pathology in the ankle or subtalar joint, and the confirmation of anterolateral soft tissue impingement would be beneficial. Level of Evidence: III, Case Control Study
Is it Necessary to Re-Fuse a Non-Union of a Hallux Metatarsophalangeal Joint Arthrodesis?
Authors: Hope Matthew , Savva Nicholas , Whitehouse Sarah , Elliot Robin , Saxby Terry S. 
Published: August 2010

Background: The standard treatment for a non-union of the hallux metatarsophalangeal joint fusion has been to revise the fusion. Revision fusion is technically more demanding, often involving bone grafting, more substantial fixation and prolonged period of immobilization postoperatively. We present data to suggest that removal of hardware and debridement alone is an alternative treatment option. Materials and Methods: A case note review identified patients with a symptomatic non-union after hallux metatarsophalangeal joint (MTPJ) fusion. It is our practice to offer these patients revision fusion or removal of hardware and debridement. For the seven patients that chose hardware removal and were left with a pseudarthrosis, a matched control group was selected from patients who had had successful fusions. Three outcome scores were used. Hallux valgus and dorsiflexion angles were recorded. Results: One hundred thirty-nine hallux MTPJ arthrodeses were carried out. Fourteen non-unions were identified. The rate of nonunion in males and following previous hallux MTPJ surgery was 19% and 24%, respectively. In females undergoing a primary MTPJ fusion, the rate was 2.4%. Twelve non-union patients were reviewed at 27 months (mean). Eleven patients had elected to undergo removal of hardware and debridement. Four patients with pseudarthrosis were unhappy with the results and proceeded to either revision fusion or MTPJ replacement. Seven non-union patients, who had removal of hardware alone, had outcome scores marginally worse compared to those with successful fusions. Conclusion: Removal of hardware alone is a reasonable option to offer as a relatively minor procedure following a failed arthrodesis of the first MTPJ. This must be accepted on the proviso that in this study four out of 11 (36%) patients proceeded to a revision first MTPJ fusion or first MTPJ replacement. We also found that the rate of non-union in primary first MTPJ fusion was significantly higher in males and those patients who had undergone previous surgery. Level of Evidence: III, Retrospective Comparative Series
Distal Chevron Osteotomy with Distal Soft Tissue Procedure for Moderate to Severe Hallux Valgus Deformity
Authors: Bai Long Bin , Lee Keun Bae , Seo Chang Young , Song Eun Kyoo , Yoon Taek Rim 
Published: August 2010

Background: Distal chevron osteotomy has been widely employed to treat mild to moderate hallux valgus deformity. The purpose of the present study was to evaluate the outcomes of distal chevron osteotomy with a distal soft tissue procedure for the correction of moderate to severe hallux valgus. Materials and Methods: We reviewed 76 patients (86 feet) that underwent distal chevron osteotomy with a distal soft tissue procedure for symptomatic moderate to severe hallux valgus deformity. At a mean followup of 31 months, all patients were evaluated using subjective, objective and radiographic measurements. Results: Ninety-four percent of the patients were very satisfied or satisfied. Average AOFAS score improved from 54.7 points preoperatively to 92.9 at final followup. Average hallux valgus angle changed from 36.2 degrees preoperatively to 12.4 degrees at final followup, and average first-second intermetatarsal angle changed from 17.1 to 7.3 degrees. Average tibial sesamoid position changed from 2.4 preoperatively to 1.2 at final followup. Dorsal angulation of the head was observed in two feet, and plantaflexion of the head in four feet. There were no cases of avascular necrosis of the metatarsal head. Conclusion: Our results indicate that distal chevron osteotomy with a distal soft tissue procedure provides an effective and reliable means of correcting moderate to severe hallux valgus deformity, and that it does so with high levels of patient satisfaction and low incidence of complications. Level of Evidence: IV, Retrospective Case Series
Comment administrer la nature ?
Authors: Simon Gilbert 
Published: August 2010

« Administrer la nature », ces termes semblent antinomiques. L’homme a une certaine idée de la nature et s’efforce de la faire prévaloir. Les politiques de protection de la nature, récentes, ont connu d’indéniables succès : des espèces et des espaces au bord de l’extinction ont été sauvés. Mais elles ont montré leurs limites tant que leur rationalité était calquée sur celles des activités économiques. L’administration actuelle de la nature a l’ambition de faire intégrer ses objectifs dans toutes les politiques publiques et privées. La France tente en 2010 de se donner les moyens d’enrayer la perte de sa biodiversité. Mais à l’échelle planétaire, l’augmentation forte de l’empreinte écologique due à la démographie et au développement apporte plutôt une note pessimiste.
Cell Cycle Arrest and Apoptosis Induction by an Anticancer Chalcone Epoxide
Authors: Han Haiyong , Zhao Yu , Cuthbertson Timothy , Hartman Rosemarie F. , Rose Seth D. 
Published: August 2010

AbstractSafe and effective chemotherapeutic agents for the treatment of pancreatic cancer remain elusive. We found that chalcone epoxides (1,3‐diaryl‐2,3‐epoxypropanones) inhibited growth in two pancreatic cancer cell lines, BxPC‐3 and MIA PaCa‐2. Three compounds were active, with GI50 values of 5.6 to 15.8 µM. Compound 4a, 1,3‐bis‐(3,4,5‐trimethoxyphenyl)‐2,3‐epoxypropanone, had an average GI50 of 14.1 µM in the NCI 60‐cell‐line panel. To investigate the mode of action, cell cycle analyses of BxPC‐3 cells were carried out. Treatment of cells with 50 µM 4a resulted in dramatic accumulation at G2/M (61% after 12 h for 4a vs. 15% for untreated cells). The cells rapidly entered apoptosis. After 12 h, 26% of cells treated with 50 µM 4a had entered apoptosis vs. 4% for cells treated with 100 µM etoposide and 2% for untreated cells. Compound 4a interfered with paclitaxel enhancement of tubulin polymerization, suggesting microtubules as the site of action. Reaction of thiol nucleophiles with 4a under basic conditions resulted in epoxide ring‐opening and retroaldol fragmentation, yielding alkylated thiol. MALDI mass spectrometry showed that retroaldol reaction occurred upon treatment of β‐tubulin with 4a. The site of alkylation was identified as Cys354. Chalcone epoxides warrant further study as potential agents for treatment of cancer.
Upstream open reading frames: Molecular switches in (patho)physiology
Authors: Wethmar Klaus , Smink Jeske J. , Leutz Achim 
Published: August 2010

AbstractConserved upstream open reading frames (uORFs) are found within many eukaryotic transcripts and are known to regulate protein translation. Evidence from genetic and bioinformatic studies implicates disturbed uORF‐mediated translational control in the etiology of human diseases. A genetic mouse model has recently provided proof‐of‐principle support for the physiological relevance of uORF‐mediated translational control in mammals. The targeted disruption of the uORF initiation codon within the transcription factor CCAAT/enhancer binding protein β (C/EBPβ) gene resulted in deregulated C/EBPβ protein isoform expression, associated with defective liver regeneration and impaired osteoclast differentiation. The high prevalence of uORFs in the human transcriptome suggests that intensified search for mutations within 5′ RNA leader regions may reveal a multitude of alterations affecting uORFs, causing pathogenic deregulation of protein expression.
Cheats as first propagules: A new hypothesis for the evolution of individuality during the transition from single cells to multicellularity
Authors: Rainey Paul B. , Kerr Benjamin 
Published: August 2010

AbstractThe emergence of individuality during the evolutionary transition from single cells to multicellularity poses a range of problems. A key issue is how variation in lower‐level individuals generates a corporate (collective) entity with Darwinian characteristics. Of central importance to this process is the evolution of a means of collective reproduction, however, the evolution of a means of collective reproduction is not a trivial issue, requiring careful consideration of mechanistic details. Calling upon observations from experiments, we draw attention to proto‐life cycles that emerge via unconventional routes and that transition, in single steps, individuality to higher levels. One such life cycle arises from conflicts among levels of selection and invokes cheats as a primitive germ line: it lays the foundation for collective reproduction, the basis of a self‐policing system, the selective environment for the emergence of development, and hints at a plausible origin for a soma/germ line distinction.
Conformational preference and cis–trans isomerization of 4‐methylproline residues
Authors: Kang Young Kee , Byun Byung Jin , Park Hae Sook 
Published: August 2010

AbstractConformational preferences and prolyl cis−trans isomerizations of the (2S,4S)‐4‐methylproline (4S‐MePro) and (2S,4R)‐4‐methylproline (4R‐MePro) residues are explored at the M06‐2X/cc‐pVTZ//M06‐2X/6‐31+G(d) level of theory in the gas phase and in water, where solvation free energies were calculated using the implicit SMD model. In the gas phase, the down‐puckered γ‐turn structure with the trans prolyl peptide bond is most preferred for both Ac‐4S‐MePro‐NHMe and Ac‐4R‐MePro‐NHMe, in which the C7 hydrogen bond between two terminal groups seems to play a role, as found for Ac‐Pro‐NHMe. Because of the C7 hydrogen bonds weakened by the favorable direct interactions between the backbone CO and HN groups and water molecules, the 4S‐MePro residue has a strong preference of the up‐puckered polyproline II (PPII) structure over the down‐puckered PPII structure in water, whereas the latter somewhat prevails over the former for the 4R‐MePro residue. However, these two structures are nearly equally populated for Ac‐Pro‐NHMe. The calculated populations for the backbone structures of Ac‐4S‐MePro‐NHMe and Ac‐4R‐MePro‐NHMe in water are reasonably consistent with CD and NMR experiments. In particular, our calculated results on the puckering preference of the 4S‐MePro and 4R‐MePro residues with the PPII structures are in accord with the observed results for the stability of the (X‐Y‐Gly)7 triple helix with X = 4R‐MePro or Pro and Y = 4S‐MePro or Pro. The calculated rotational barriers indicate that the cis−trans isomerization may in common proceed through the anticlockwise rotation for Ac‐4S‐MePro‐NHMe, Ac‐4R‐MePro‐NHMe, and Ac‐Pro‐NHMe in water. The lowest rotational barriers become higher by 0.24−1.43 kcal/mol for Ac‐4S‐MePro‐NHMe and Ac‐4R‐MePro‐NHMe than those for Ac‐Pro‐NHMe in water. © 2010 Wiley Periodicals, Inc. Biopolymers 95: 51–61, 2011.
ChemInform Abstract: Dynamics on an ab initio Surface for Calculating JHH NMR Exchange Coupling. The Case of OsH3X(PH3)2
Authors: CLOT E. , LEFORESTIER C. , EISENSTEIN O. , PELISSIER M. 
Published: August 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: N8: A Structure Analogous to Pentalene, and Other High Energy Density Minima.
Authors: LEININGER M. L. , SHERRILL C. D. , SCHAEFER H. F. III 
Published: August 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Structure of Cu2.5(OH)3SO4×2 H2O: A Novel Corrosion Product of Copper.
Authors: STRANDBERG H. , LANGER V. , JOHANSSON L.‐G. 
Published: August 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Polymorphs of Ln2MoO6: A Neutron Diffraction Investigation of the Crystal Structures of La2MoO6 and Tb2MoO6.
Authors: XUE J. S. , ANTONIO M. R. , SODERHOLM L. 
Published: August 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Basic Properties of Mg2+ 1‐xAl3+ x Layered Double Hydroxides (LDH) Intercalated by Carbonate, Hydroxide, Chloride, and Sulfate Anions.
Authors: CONSTANTINO V. R. L. , PINNAVAIA T. J. 
Published: August 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: The Infinite Chain Nitride Na5Ba3N. A One‐Dimensional Void Metal?
Authors: SNYDER G. J. , SIMON A. 
Published: August 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Magnetic Properties of Rare‐Earth Metallofullerenes.
Authors: FUNASAKA H. , SUGIYAMA K. , YAMAMOTO K. , TAKAHASHI T. 
Published: August 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: In2ZrBr6: A Van Vleck‐Type Paramagnetism by Indirect Coupling.
Authors: DRONSKOWSKI R. 
Published: August 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Negative Thermal Expansion and Phase Transitions in the ZrV2‐xPxO7 Series.
Authors: KORTHUIS V. , KHOSROVANI N. , SLEIGHT A. W. , ROBERTS N. , DUPREE R. , WARREN W. W. JUN. 
Published: August 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Lithium Insertion in Carbons Containing Nanodispersed Silicon.
Authors: WILSON A. M. , DAHN J. R. 
Published: August 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Sulfur Hexafluoride Reactive Ion Etching of (111) β‐SiC Epitaxial Layers, Grown on (111) TiC Substrates.
Authors: WU J. , PARSONS J. D. , EVANS D. R. 
Published: August 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Simultaneous Removal of Nitrogen Oxides and Diesel Soot Particulates Catalyzed by Perovskite‐Type Oxides.
Authors: TERAOKA Y. , NAKANO K. , KAGAWA S. , SHANGGUAN W. F. 
Published: August 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: An XPS Study of Metallic Three‐Way Catalysts: The Effect of Additives on Platinum, Rhodium, and Cerium.
Authors: TALO A. , LAHTINEN J. , HAUTOJAERVI P. 
Published: August 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Selective Catalytic Reduction of Sulfur Dioxide with Hydrogen to Elemental Sulfur over Co‐Mo/Al2O3.
Authors: PAIK S. C. , CHUNG J. S. 
Published: August 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Reaction Mechanism of Electroless Metal Deposition Using ZnO Thin Film. Part 1. Process of Catalyst Formation.
Authors: YOSHIKI H. , HASHIMOTO K. , FUJISHIMA A. 
Published: August 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Aqueous Peroxynitric Acid (HOONO2): A Novel Synthesis and Some Chemical and Spectroscopic Properties.
Authors: APPELMAN E. H. , GOSZTOLA D. J. 
Published: August 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.