bluuebunny/crossref_metadata_2025_split huggingface dataset:
Understanding antecedents of new product development speed: A meta‐analysis
Authors: Chen Jiyao , Damanpour Fariborz , Reilly Richard R. 
Published: July 2009

AbstractNew product development (NPD) speed is a key component of time‐based strategy, which has become increasingly important for managing innovation in a fast‐changing business environment. This meta‐analytic review assesses the generalizability of the relationships between NPD speed and 17 of its antecedents to provide a better understanding of the salient and cross‐situationally consistent factors that affect NPD speed. We grouped the antecedents into four categories of strategy, project, process, and team, and found that process and team characteristics are more generalizable and cross‐situationally consistent determinants of NPD speed than strategy and project characteristics. We also conducted subgroup analyses and found that research method variables, such as level of analysis, source of data, and measurement of speed, moderate the relationships between NPD speed and its antecedents. We apply the study's findings to assess several models of NPD speed, such as the balanced model of product development, the strategic orientation and organizational capability model, the compression vs. the experiential model, the centrifugal and centripetal model, and the product development cycle time model. We also discuss the implications of our findings for research and practice.
Dietary carbohydrates, glycaemic load, food groups and newly detected type 2 diabetes among urban Asian Indian population in Chennai, India (Chennai Urban Rural Epidemiology Study 59)
Authors: Mohan Viswanathan , Radhika Ganesan , Sathya Rangaswamy Mohan , Tamil Selvi Ramjothi , Ganesan Anbazhagan , Sudha Vasudevan 
Published: July 2009

The aim of the study was to examine the association of dietary carbohydrates and glycaemic load with the risk of type 2 diabetes among an urban adult Asian Indian population. Adult subjects aged >20 years (n 1843) were randomly selected from the Chennai Urban Rural Epidemiology Study, in Chennai city in southern India. Dietary carbohydrates, glycaemic load and food groups were assessed using FFQ. Oral glucose tolerance tests were performed using 75 g glucose in all subjects. Diagnosis of diabetes was based on WHO Consulting Group criteria. OR for newly detected diabetes were calculated for carbohydrates, glycaemic load and specific food groups comparing subjects in the highest with those in the lowest quartiles, after adjustment for potential confounders such as age, sex, BMI, family history of diabetes, physical activity, current smoking, alcohol consumption and relevant dietary factors. We identified 156 (8·5 %) newly diagnosed cases of type 2 diabetes. Refined grain intake was positively associated with the risk of type 2 diabetes (OR 5·31 (95 % CI 2·98, 9·45); P < 0·001). In the multivariate model, after adjustment for potential confounders, total carbohydrate (OR 4·98 (95 % CI 2·69, 9·19), P < 0·001), glycaemic load (OR 4·25 (95 % CI 2·33, 7·77); P < 0·001) and glycaemic index (OR 2·51 (95 % CI 1·42, 4·43); P = 0·006) were associated with type 2 diabetes. Dietary fibre intake was inversely associated with diabetes (OR 0·31 (95 % CI 0·15, 0·62); P < 0·001). In urban south Indians, total dietary carbohydrate and glycaemic load are associated with increased, and dietary fibre with decreased, risk of type 2 diabetes.
Mapping multiple quantitative trait loci under Bayes error control
Authors: SHRINER DANIEL 
Published: July 2009

SummaryIn mapping of quantitative trait loci (QTLs), performing hypothesis tests of linkage to a phenotype of interest across an entire genome involves multiple comparisons. Furthermore, linkage among loci induces correlation among tests. Under many multiple comparison frameworks, these problems are exacerbated when mapping multiple QTLs. Traditionally, significance thresholds have been subjectively set to control the probability of detecting at least one false positive outcome, although such thresholds are known to result in excessively low power to detect true positive outcomes. Recently, false discovery rate (FDR)-controlling procedures have been developed that yield more power both by relaxing the stringency of the significance threshold and by retaining more power for a given significance threshold. However, these procedures have been shown to perform poorly for mapping QTLs, principally because they ignore recombination fractions between markers. Here, I describe a procedure that accounts for recombination fractions and extends FDR control to include simultaneous control of the false non-discovery rate, i.e. the overall error rate is controlled. This procedure is developed in the Bayesian framework using a direct posterior probability approach. Data-driven significance thresholds are determined by minimizing the expected loss. The procedure is equivalent to jointly maximizing positive and negative predictive values. In the context of mapping QTLs for experimental crosses, the procedure is applicable to mapping main effects, gene–gene interactions and gene–environment interactions.
Pedigree analysis for conservation of genetic diversity and purging
Authors: WELLMANN R. , PFEIFFER I. 
Published: July 2009

SummaryWe present an approach to describe and evaluate changes in genetic diversity and to calculate bounds for improvement. This pedigree-based analysis was applied to the Kromfohrländer dog (FCI Gr9 Sec10). Pedigrees trace back to the foundation of the breed and were available for 5527 individuals. Based on this dataset the population structure and historical bottlenecks were studied. Distributions of allele frequencies were estimated by Monte Carlo simulation. To monitor changes in mating systems throughout the breeding history, the homozygosity of alleles was compared with their expectations in Hardy–Weinberg equilibrium. Different breeding lines were identified by hierarchical cluster analysis and were characterized by ancestor contributions. Our calculations showed that the founder event in 1945 was followed by two bottlenecks. One was caused by strong selection in a very small population, and the other was triggered by rigorous disease management. The necessary amount of purging that arised due to the bottlenecks was also discussed.
The postcranial skeleton ofMonolophosaurus jiangi(Dinosauria: Theropoda) from the Middle Jurassic of Xinjiang, China, and a review of Middle Jurassic Chinese theropods
Authors: XI-JIN ZHAO , BENSON ROGER B. J. , BRUSATTE STEPHEN L. , CURRIE PHILIP J. 
Published: July 2009

AbstractThe Middle Jurassic was a critical time in the evolution of theropod dinosaurs, highlighted by the origination and radiation of the large-bodied and morphologically diverse Tetanurae. Middle Jurassic tetanurans are rare but have been described from Europe, South America and China. In particular, China has yielded a number of potential basal tetanurans, but these have received little detailed treatment in the literature. Here we redescribe the postcranial skeleton of one of the most complete Chinese Middle Jurassic theropods,Monolophosaurus. Several features confirm the tetanuran affinities ofMonolophosaurus, but the possession of ‘primitive’ traits such as a double-faceted pubic peduncle of the ilium and a hood-like supracetabular crest suggest a basal position within Tetanurae. This conflicts with most published cladistic analyses that placeMonolophosaurusin a more derived position within Allosauroidea. We review the Middle Jurassic record of Chinese theropods and compareMonolophosaurusto other Middle Jurassic theropods globally. These comparisons suggest thatMonolophosaurusandChuandongocoelurusformed an endemic theropod clade limited to the Middle Jurassic of Asia. Other Middle Jurassic Chinese theropods deserve further study.
The effect of fishing on growth of the clam Chamelea gallina (Bivalvia: Veneridae) from the Turkish Black Sea coast
Authors: Dalgiç Göktuğ , Okumuş İbrahım , Karayücel Sedat 
Published: July 2009

Age and growth of the clam Chamelea gallina from dredged, non-dredged and closed areas of the Turkish Black Sea coast were estimated. Von Bertalanffy growth curves were fitted for each sampling site; asymptotic length (L∞) values ranged between 25.995 and 28.883 mm and the growth coefficient (K) from 0.164 to 0.217 per year. Results indicate growth rates were significantly reduced in the far eastern commercial populations compared with those in western populations. According to our results presented here it can be concluded that C. gallina at closed area does not grow as fast as non-dredged stock and this is because of the shortness of closure season. Nevertheless we suggest that fallowing is the major precaution for the recovery of C. gallina stocks in the Black Sea.
Expanded description of Opisthoteuthis hardyi based on new specimens from the Patagonian slope
Authors: Collins Martin A. , Laptikhovsky Vladimir , Strugnell Jan M. 
Published: July 2009

Opisthoteuthis hardyi was originally described from a single male specimen caught near Shag Rocks (north-west of South Georgia) and no further specimens have been attributed to this species. During research fishing on the Patagonian slope to the south-east of the Falkland Islands 33 specimens of Opisthoteuthis were caught at depths ranging from 630 to 1391 m. Morphological measurements indicated that these specimens were conspecific to the holotype of O. hardyi. The mitochondrial gene 16S rDNA was sequenced from two of these specimens and compared with a published sequence of the holotype and other Opisthoteuthidae to confirm the morphological data. This extends the geographical and bathymetric range of the species, which spans the Antarctic Polar Front. We also expand the original description, providing details of the digestive system and of the female reproductive system, with preliminary estimates of fecundity.
Incidence of schizophrenia in Ireland
Authors: Nuallain Mairin Ni , O'hare Aileen , Walsh Dermot 
Published: July 2009

SynopsisThis paper reports an investigation of the incidence of schizophrenia in Ireland by means of standardized case-finding procedures. Our findings do not support the popular belief, based on first admissions figures, of a raised incidence in Ireland. We show this to have been considerably overestimated.
Personality disorder in mental handicap
Authors: Reid Andrew H. , Ballinger Brian R. 
Published: July 2009

Synopsis100 randomly selected mildly or moderately mentally retarded adults were assessed for personality disorder using the Standardized Assessment of Personality devised by Mann et al. (1981). By the terms of this instrument 56% of patients showed features of abnormal personality, and in 22% this abnormality was marked, suggesting the presence of personality disorder. Personality problems may be a more significant factor in assessing a mentally retarded person's acceptability in a community setting than has hitherto been realized.
Metals and magnets in medicine: hysteria, hypnosis and medical culture in fin-de-siècle Paris
Authors: Harrington Anne 
Published: July 2009

SynopsisIt is well known that the end of the nineteenth century represented a ‘golden age’ of hysteria and hypnosis research under Jean-Martin Charcot in Paris, but the extent to which metals and magnets figured in this strange and provocative world has been very incompletely told. This paper offers itself as a first corrective to this neglect. In 1876 a certain elderly physician and mesmerist, Victor Burq, asked the Parisian Société de Biologie formally to establish the validity of his so-called ‘metallotherapy’ (later ‘metalloscopy’) treatment for hysteria. The paper argues that Charcot's participation in the investigation of Burq's work – undertaken in conjunction with two other leading French neurologists, Amédée Dumontpallier and Jules Bernard Luys – served as a major catalyst in arousing the great neurologist's interest in hypnosis in the first place, and was subsequently responsible for several of his key beliefs about the underlying physiological link between hypnosis and hysteria. It is also shown how these early metalloscopy studies – and especially the discovery by Charcot and his colleagues of so-called metalloscopic ‘transfer’ – opened the door to the rise of a neo-mesmeric, and increasingly occult, branch of hypnosis research in French psychiatry, which has to date, in the secondary literature, gone almost wholly unremarked.
The effects of experimentally induced respiratory virus infections on performance
Authors: Smith A. P. , Tyrrell D. A. J. , Al-Nakib W. , Coyle K. B. , Donovan C. B. , Higgins P. G. , Willman J. S. 
Published: July 2009

SynopsisStudies of experimentally induced respiratory infections and illnesses showed that influenza impaired performance on a visual search task but had no effect on a simple motor task, whereas colds impaired the motor task but not the search task. The effect of influenza on the search task was observed in both volunteers with significant clinical symptoms and volunteers who were shown, by virological techniques, to be infected but who had no significant clinical illness. Performance was also impaired during the incubation period of this illness, which confirms that subclinical influenza virus infections can have behavioural effects. In contrast to influenza, the effects of colds were restricted to volunteers who had significant clinical symptoms, and the impairments in performance were observed only when the symptoms were apparent.
Urinary-free cortisol in depressed patients and controls: relationship to urinary indices of noradrenergic function
Authors: Roy Alec , Linnoila Markku , Karoum Farouk , Pickar David 
Published: July 2009

SynopsisWe measured urinary outputs of urinary-free cortisol in 28 medication-free depressed patients and 32 normal controls. Depressed patients had significantly greater urinary outputs of urinary-free cortisol than controls. Also, there were significant correlations among depressed patients, but not among controls, between urinary-free cortisol and urinary outputs of norepinephrine and its metabolite vanillylmandelic acid (VMA). These urinary data extend recent findings suggesting that dysregulation of both the hypothalamic-pituitary-adrenal axis and noradrenergic system occur together in depression.
Language and dementia: a review
Authors: Hart Siobhan 
Published: July 2009

SynopsisIn the literature on dementia the presence or absence of language deficits has come to occupy a pivotal position with respect to certain nosological and nosographical issues. These are reviewed critically, together with the results of experimental investigations which have sought to elucidate the nature of the language deficit(s) in patients with dementia, especially that of the Alzheimer type. Attention is drawn to important gaps in current knowledge and suggestions are made regarding the direction of future research.
Lycanthropy: alive and well in the twentieth century
Authors: Keck Paul E. , Pope Harrison G. , Hudson James I. , McElroy Susan L. , Kulick Aaron R. 
Published: July 2009

SynopsisLycanthropy, the belief that one has been transformed into an animal (or behaviour suggestive of such a belief), has been described by physicians and clerics since antiquity, but has received scant attention in the modern literature. Some have even thought the syndrome extinct. However, in a review of patients admitted to our centre since 1974, we identified twelve cases of lycanthropy, ranging in duration from one day to 13 years. The syndrome was generally associated with severe psychosis, but not with any specific psychiatric diagnosis or neurological findings, or with any particular outcome. As a rare but colourful presentation of psychosis, lycanthropy appears to have survived into modern times.
The Geriatric Mental State (GMS) used in the community: replication studies of the computerized diagnosis AGECAT
Authors: Copeland J. R. M. , Dewey M. E. , Henderson A. S. , Kay D. W. K. , Neal C. D. , Harrison M. A. M. , McWilliam C. , Forshaw D. , Shiwach R. 
Published: July 2009

SynopsisThree studies are reported using the Geriatric Mental State in one of its community forms on a total of 647 subjects aged over 65 and living in their own homes. The concordance between the computer diagnosis AGECAT and psychiatrists' diagnosis is at least as good in these replication samples as in the original studies (Copeland et al. 1986). AGECAT has been shown to be useful for epidemiological surveys and as a diagnostic guide for non-medical interviewers.
The placebo concept in medicine and psychiatry
Authors: Grünbaum Adolf 
Published: July 2009

SynopsisThe standard technical vocabulary used to define placebo therapies and experimental placebo controls in medicine and psychiatry is both confusing and obscure. To achieve conceptual clarity in the theory of placebogenic phenomena, this paper offers (1) a rigorous articulation of the placebo notion, (2) a lucid new terminology that obviates the defects intrinsic to the traditional locutions employed in the placebo literature, and (3) a substantial revamping of A. K. Shapiro's influential prior definition of‘placebo’. This paper supersedes an earlier version (Grünbaum, 1981).
Validity of the scaled version of the General Health Questionnaire (GHQ-28) in a Spanish population
Authors: Lobo Antonio , Pérez-Echeverría Maria Jesús , Artal Jesus 
Published: July 2009

SynopsisThis study confirms the validity of a Spanish version of the General Health Questionnaire in its scaled 28-item version. The screening instrument was tested on a sample of 100 patients attending an internal medicine out-patient clinic, who were examined independently by psychiatrists standardized in the use of the Clinical Interview Schedule (CIS). The questionnaire correctly identified 85% of “cases” with a cutting score of 6/7 (sensitivity 76·9%, specificity 90·2%), and 83% of cases with a cutting score of 5/6 (sensitivity 84·6%, specificity 82%), suggesting a discriminative power almost as good as the Spanish GHQ-60. It has the important advantage of being considerably shorter and, although the 4 subscales are by no means independent, its concurrent validity with CIS ratings suggests that they provide additional information concerning anxiety and depression.
Population screening and the early detection of dementing disorders in old age: a review
Authors: Cooper Brian , Bickel Horst 
Published: July 2009

SynopsisThe scope for the early detection of dementing disorders in the elderly by means of screening techniques is reviewed in the light of the basic principles of early disease detection. It is concluded that, while there is an increasingly urgent need for the development and application of psychogeriatric screening methods as a step towards preventive action, such methods are still at an early experimental stage. Prescriptive screening programmes are contra-indicated at present. The most immediate requirement is for evaluative research, which should be planned to take account both of the properties of the screening instruments and of the health-care and social settings in which these are to be applied. No major progress in this field can be expected unless it proves possible to integrate methods of early case-detection, and of systematic surveillance of the at-risk elderly, into the work of primary medical and social services.
A statistical modelling approach to community prevalence data
Authors: Knuiman M. W. , Burvill P. W. 
Published: July 2009

SynopsisSample survey techniques are often used to assess the prevalence of illness in a community and to determine any variation with environmental, social and demographic factors. Analysis of survey data is often carried out using several elementary statistical procedures. The formulation of a statistical model is an effective way of conducting a unified analysis. The model provides a concise description of the study population and is a most effective way of summarizing community prevalence data. The testing of statistical hypotheses is equivalent to model simplification and is conveniently performed using general procedures. Two alternative statistical models are given for an investigation into the extent of minor psychiatric morbidity in Perth, Western Australia.
The relevance of socio-demographic and resource factors in the use of acute psychiatric in-patient care in the Atlantic Provinces of Canada
Authors: Richman Alex , Boutilier Carol , Harris Pamela 
Published: July 2009

SynopsisThis study assessed the inter-relations of socio-demographic, resource and policy factors with standardized measures of short-term psychiatric bed-use in 42 counties of Atlantic Canada. The policy factor made up two-thirds of the total variability (61%) accounted for among males, and nearly one-half of the 47% accounted for among females. An accurate assessment of in-patient resource needs is seen as resulting from intertwining morbidity surveys with utilization studies.
Mental distress in mothers of young children in Harrogate
Authors: Berg Ian , Butler Alan , Houston Jackson , McGuire Ralph 
Published: July 2009

SynopsisTwo hundred and forty women with young children who were patients in a Harrogate general practice were studied. About a third of them were found to be suffering from ‘mental distress’. Younger mothers were more affected. The number and spacing of their children were not related to symptoms of depression and anxiety, but poor personal relationships and difficulties getting out and about were so related, despite relatively affluent circumstances. Children of distressed mothers were more inclined to be disturbed. A controlled trial using amitryptyline involving 25 of the women suggested that this drug can improve depressive symptoms under these circumstances and that the improvement is likely to be maintained over the course of a year.
The pineal and psychiatry: a review
Authors: Mullen P. E. , Silman R. E. 
Published: July 2009

SynopsisThe pineal in man is an active endocrine gland throughout life. Historically the gland has been associated with speculation on the nature of mind and its disorders. Modern research is now demonstrating it to be an endocrine gland capable of affecting the brain and behaviour. The implications for future research into this aspect of pineal function are discussed in the context of a critical review of the current literature.
Significance of androgen levels in the aetiology and treatment of homosexuality
Authors: James Sheelah , Carter R. A. , Orwin A. 
Published: July 2009

SynopsisSerum total androgens were estimated by radioimmunoassay on blood samples of treatment-seeking homosexuals and heterosexual controls. There was no significant difference in androgen levels between the homosexual and control group, nor was there any relationship between androgen levels and response to treatment. These results suggest that androgen levels have no aetiological significance in treatment-seeking homosexuals and have no relevance as indicators of treatment outcome.
Psychiatric illness, maladjustment and juvenile delinquency: an ecological study in a London borough
Authors: Cooper Brian , Gath Dennis 
Published: July 2009

SynopsisPatterns of adult psychiatric referral, of child guidance referral and of juvenile delinquency in a metropolitan borough were examined. The 3 sets of rates showed parallel trends among the 20 electoral wards of the borough, all 3 being similarly related to socio-demographic indices. A cluster analysis technique was used to combine the 450 enumeration districts of the borough into 22 clusters defined by social characteristics rather than by geographical boundaries. Ecological correlates of treated psychiatric disorder and of delinquency, based on these clusters, were found to be similar to those derived from the electoral ward data.The findings suggest that it may be possible to demarcate relatively small urban areas with high concentrations of psychiatric disorder, maladjustment and delinquency.