bluuebunny/crossref_metadata_2025_split huggingface dataset:
The trans Influence in the Modulation of Platinum Anticancer Agent Biology: The Effect of Nitrite Leaving Group on Aquation, Reactions with S‐Nucleophiles and DNA Binding of Dinuclear and Trinuclear Compounds
Authors: Montero Eva I. , Zhang Junyong , Moniodis Joseph J. , Berners‐Price Susan J. , Farrell Nicholas P. 
Published: June 2010

AbstractTo examine the effect of leaving group and trans influence on the general reactivity of polynuclear platinum antitumor agents we investigated substitution of the chloride leaving groups with nitrite ion, which forms strong bonds to Pt. It was of interest to explore whether nitrite could be used to modulate biological properties of these agents, in particular the deactivating reactions that occur on reaction with S‐nucleophiles, involving loss of the linking diamine under the trans influence of sulfur. Reported herein is a study of the synthesis, aquation, DNA binding and reactions with glutathione (GSH), methionine (Met) and acetylmethione (AcMet) of nitrito derivatives of di‐ and trinuclear platinum antitumor compounds: [{trans‐PtNO2(NH3)2}2(μ‐NH2(CH2)6NH2)](NO3)2 (1‐NO2) and [{trans‐PtNO2(NH3)2}2(μ‐trans‐Pt(NH3)2{NH2(CH2)6NH2}2)](NO3)4 (1′‐NO2). {1H,15N}‐HSQC NMR studies revealed that 1‐NO2 is inert to aquation reactions, even after prolonged incubation at physiological pH. Monitoring of the interaction of 1‐NO2 with the duplex 5′‐d(ATATGTACATAT)2 (I) showed only unreacted complex, consistent with activation by aquation being a requirement for covalent DNA binding. The reaction of 1‐NO2 with GSH was studied by 1H, 195Pt, 15N and {1H,15N}‐HSQC NMR spectroscopy. For the parent dichlorido compounds (1 and 1′) substitution of chloride by GS− leads to drug degradation involving liberation of the diamine linker. While the same final products trans‐[Pt(SG)2(NH3)2] (5) and trans‐[{Pt(SG)(NH3)2}2‐μ‐SG] (6) are formed, different mechanisms are involved, consistent with the trans influence NO2− > Cl−; the half‐life is slightly longer for 1‐NO2 (1.8 h) compared with 1 (1.3 h). Identification of the intermediate trans‐[Pt(NH3)2(NO2)(SG)] (4) shows that the nitrito group remains coordinated while the linker amine is substituted by coordination of GS−, and then trans labilization of the nitrito group occurs leading to 5 and 6. Reaction of the trinuclear 1′‐NO2 with GSH follows essentially the same reaction pathway. Reaction of 1‐NO2 with Met and AcMet is much slower and only 20 % liberated amine was observed after reaction with Met for 24 h at 37 °C. The final product from reaction with AcMet is trans‐[Pt(NH3)2(NO2)(AcMet)], as in this case coordination of the S‐nucleophile does not lead to trans labilization of the nitrito group.
ChemInform Abstract: Enhanced Reactivity of Tuned Imidazolidin‐2‐one Chiral Auxiliaries in Diels—Alder Reactions.
Authors: ROOS G. H. P. , BALASUBRAMANIAM S. 
Published: June 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Diphenylphosphinooxazoline Ligands with a Chiral Binaphthyl Backbone for Pd‐Catalyzed Allylic Alkylation.
Authors: IMAI Y. , ZHANG W. , KIDA T. , NAKATSUJI Y. , IKEDA I. 
Published: June 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Effect of Phosphorylation on the Reaction Rate of Unnatural Electrophiles with 2‐Keto‐3‐deoxy‐6‐phosphogluconate Aldolase.
Authors: COTTERILL I. C. , SHELTON M. C. , MACHEMER D. E. W. , HENDERSON D. P. , TOONE E . J. 
Published: June 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Zinc Barbier Reaction of Propargyl Halides in Water.
Authors: BIEBER L. W. , DA SILVA M. F. , DA COSTA R. C. , SILVA L. O. S. 
Published: June 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Tandem [4 + 2]/[3 + 2] Cycloadditions with Nitroethylene.
Authors: DENMARK S. E. , HURD A. R. 
Published: June 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: First Example of Samarium Diiodide‐Promoted Sequential Cyclization and Ring‐Expansion Reactions of α‐Bromomethyl Cyclic β‐Keto Esters to Homologated γ‐Keto Esters.
Authors: HASEGAWA E. , KITAZUME T. , SUZUKI K. , TOSAKA E. 
Published: June 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: DTBB‐Catalyzed Lithiation of 3‐Functionalized 1‐Chloropropenes.
Authors: GOMEZ C. , HUERTA F. F. , YUS M. 
Published: June 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Reaction of Thexylalkoxyboranes with Selected Organic Compounds Containing Representative Functional Groups. Comparison of Reducing Characteristics of the Alkoxy Derivatives.
Authors: CHA J. S. , CHANG S. W. , KIM J. M. , KWON O. O. , CHUN J. H. , CHO S. D. 
Published: June 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Phenyltetrafluorotelluromethoxide — A New Oxidative Fluorinating Agent for Olefins.
Authors: LERMONTOV S. A. , BAKHTIN I. V. 
Published: June 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis of Fluorinated Azulenes.
Authors: MUTHYALA R. S. , LIU R. S. H. 
Published: June 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Using NBS as a Mild Bromination Reagent for Polyalkoxyaromatic Systems.
Authors: BLOOMER J. L. , ZHENG W. 
Published: June 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Condensation of Fluorinated Carbonyl Compounds with Halobenzenes.
Authors: STERLIN S. R. , SHAPOSHNIKOVA E. N. , POSTOVOI S. A. , MYSOV E. I. , ZEIFMAN YU. V. 
Published: June 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Lithium Naphthalenide Induced Reductive Alkylation of α‐Cyano Ketones. A General Method for Regiocontrol of α,α‐Dialkylation of Ketones.
Authors: LIU H.‐J. , ZHU J.‐L. , SHIA K.‐S. 
Published: June 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Reusable Polymer‐Supported Palladium Catalysts: An Alternative to Tetrakis(triphenylphosphine)palladium in the Suzuki Cross‐Coupling Reaction.
Authors: FENGER I. , LE DRIAN C. 
Published: June 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis of Sterically Hindered Esters via Titanium Catalyzed Transesterification.
Authors: KRASIK P. 
Published: June 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Solid State Acetylation with Acetylimidazole: Selective Protection of Primary Alcohols and Phenols.
Authors: HAGIWARA H. , MOROHASHI K. , SUZUKI T. , ANDO M. , YAMAMOTO I. , KATO M. 
Published: June 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: The Regioselectivity of 1,3‐Disubstituted Allylmetal Species Towards Electrophiles: 1‐(Trimethylsilyl)alk‐2‐enylpotassium Compounds.
Authors: SCHLOSSER M. , FRANZINI L. 
Published: June 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: A Facile Perfluoroallylation of Olefins.
Authors: NGUYEN B. V. , YANG Z.‐Y. , BURTON D. J. 
Published: June 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis of Dinitrosohydrazine Salts.
Authors: LEKOMTSEV A. I. , ZAKHAROVA S. YA. , BAZANOV A. G. , TEMCHENKO V. G. 
Published: June 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: A Convenient Preparation of 4,4‐Dimethoxybutanal by Ozonolysis of 1,5‐Cyclooctadiene.
Authors: LI P. , WANG J. , ZHAO K. 
Published: June 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis of γ‐Fluoro‐α‐methyl‐α‐amino Acids. A New Alkylation Procedure for Ester Imines.
Authors: HAUFE G. , LAUE K. W. , TRILLER M. U. , TAKEUCHI Y. , SHIBATA N. 
Published: June 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Preparation of 1‐Alkynyl 2‐(Trimethylsilyl)ethyl Sulfides as Thiolate Anion Precursors for Self‐Assembled Monolayers.
Authors: TAKEDA H. , SHIMADA S. , OHNISHI S. , NAKANISHI F. , MATSUDA H. 
Published: June 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Intramolecular Cationic [5 + 2]Cycloaddition Reaction of Penta‐Substituted Phenols by Using Anodic Oxidation.
Authors: TAKAKURA H. , YAMAMURA S. 
Published: June 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Oxidation of α‐Alkylbenzyl Alcohols Catalyzed by 5,10,15,20‐Tetrakis(pentafluorophenyl)porphyrin Iron(III) Chloride. Competition Between C—H and C—C Bond Cleavage.
Authors: BACIOCCHI E. , BELVEDERE S. , BIETTI M. 
Published: June 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Indium‐Mediated Pinacol Coupling Reaction of Aromatic Aldehydes in Aqueous Media.
Authors: LIM H. J. , KEUM G. , KANG S. B. , CHUNG B. Y. , KIM Y. 
Published: June 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Preparation and Structure of New Homochiral Diazaphosphole Ligands and Their Platinum(II) Chloride Complexes.
Authors: VASCONCELOS I. C. F. , ANDERSON G. K. , RATH N. P. , SPILLING C. D. 
Published: June 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: A Novel Photorearrangement of Aryl Naphthylmethyl Ethers. Formation of Cyclohexa‐2,4‐dienone Derivatives.
Authors: YOSHIMI Y. , SUGIMOTO A. , MAEDA H. , MIZUNO K. 
Published: June 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis and Electrochemical Properties of New C60‐Acceptor and ‐Donor Dyads.
Authors: DIEKERS M. , HIRSCH A. , PYO S. , RIVERA J. , ECHEGOYEN L. 
Published: June 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: A pH Study on the Chiral Ketone Catalyzed Asymmetric Epoxidation of Hydroxyalkenes.
Authors: WANG Z.‐X. , SHI Y. 
Published: June 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Antiaromatic Compounds. Part 30. The Reactivity of a Kinetically Stabilized Azete Towards Mesoionic Compounds.
Authors: BACH P. , BERGSTRAESSER U. , LEININGER S. , REGITZ M. 
Published: June 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Optical Resolution of 3‐(Silyloxy)glutaric Acid Half Esters and Their Utilization for Enantioconvergent Synthesis of a HMG‐CoA Reductase Inhibitor.
Authors: KONOIKE T. , OKADA T. , ARAKI Y. 
Published: June 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: A Convenient Methodology for the N‐Alkylation of Isatin Compounds.
Authors: GARDEN S. J. , TORRES J. C. , DA SILVA L. E. , PINTO A. C. 
Published: June 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: The Reactivity of Aldehyde (or Ketone) and α‐Amino Acid Towards the Synthetic Reaction of [60]Fulleropyrrolidine Derivative.
Authors: ZHENG D.‐G. , LI C.‐W. , LI Y.‐L. 
Published: June 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Oxidative Alkylation of Azoles. Part 5. Synthesis of 4‐Nitro‐N‐chloroimidazole and Its Reaction with Methyl Iodide.
Authors: VERETENNIKOV E. A. , PEVZNER M. S. 
Published: June 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: An Improved Large‐Scale Preparation of Benzimidazole‐2‐sulfonic Acids and 2‐Chlorobenzimidazoles.
Authors: HINKLEY J. M. , PORCARI A. R. , WALKER J. A. II , SWAYZE E. E. , TOWNSEND L. B. 
Published: June 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: An Efficient and Versatile Method for the Synthesis of Optically Active 2‐Oxazolines: An Acid‐Catalyzed Condensation of Ortho Esters with Amino Alcohols.
Authors: KAMATA K. , AGATA I. , MEYERS A. I. 
Published: June 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: One‐Pot Synthesis of Isoxazoline Derivatives by Sonochemical Activation.
Authors: BOUGRIN K. , LAMIRI M. , SOUFIAOUI M. 
Published: June 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Oxidation of 3‐Amino‐1,2,4‐triazoles to 3‐Nitro‐1,2,4‐triazoles with Sodium Perborate.
Authors: TOLSTYAKOV V. V. , PEVZNER M. S. 
Published: June 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: 1,1′,2,2′,3,3′‐Tetrathiadiazafulvalenes; Preparation and Characterization of trans‐[ClCNS2C=CS2NCCl].
Authors: BARCLAY T. M. , CORDES A. W. , OAKLEY R. T. , PREUSS K. E. , REED R. W. 
Published: June 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: The Synthesis and Confirmatory Structural Characterization of Tetradentate Chelators Based on Kojic Acid.
Authors: FOX R. C. , TAYLOR P. D. 
Published: June 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: What is the Origin of Highly Asymmetric Induction by a Chiral (Salen)manganese(III) Complex? Design of a Conformationally Fixed Complex and Its Application to Asymmetric Epoxidation of 2,2‐Dimethylchromenes.
Authors: ITO Y. N. , KATSUKI T. 
Published: June 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.