bluuebunny/crossref_metadata_2025_split huggingface dataset:
Composite evaluation method for route selection of linear underground space engineering based on numerical simulation and analytical hierarchy process
Authors: Xiaozhou Z 
Published: May 2024

Abstract
Currently, in the planning phase of linear underground space engineering, route selection evaluations rely mostly on qualitative methods or the quantitative Analytic Hierarchy Process (AHP). However, these evaluation methods often fail to adequately consider the specific effects of linear underground space engineering on the surface and surrounding structures during the planning phase. This study proposes a composite evaluation method based on numerical simulations and the AHP. For risk assessment, the AHP method was used to evaluate the risks of various indicators for linear underground engineering. In numerical simulations, automated modeling is employed to quantitatively analyze the effects of linear underground space engineering on geological strata and surrounding structures. The results of the AHP method and numerical simulation were combined as a composite evaluation method to analyze route selection in linear underground space engineering. Finally, this method is demonstrated through a case study of a proposed rail transit project on the Yuzhong Peninsula, Chongqing.
Impact of climate change on underground transport infrastructure
Authors: Porro R P , O´Donovan J , Li Z 
Published: May 2024

Abstract
Globally, underground transport infrastructures in many countries face significant challenges owing to extreme weather events, such as heavy rainfall, extreme temperature changes, and rising sea levels. Consequently, it is critical to perform a comprehensive examination of the diverse effects of these climatic phenomena on underground transport infrastructures and their ability to mitigate such consequences. This study focuses on assessing the impact of climate change on underground transport infrastructures using innovative monitoring tools. Wireless sensor networks (WSNs) and do it yourself (DIY) drones will be deployed to monitor these assets to detect potential problems at an early stage. This approach involves collecting real-time data through WSNs and capturing high-quality images using drone flights. The objective is to achieve an efficient response to extreme weather events and to enhance our understanding of the impact of climate change on underground transport infrastructures.
Research on intelligent identification and resource utilization of TBM muck in breezy granite strata
Authors: You Yuyang , Yang Junsheng , Tang Yu , Yang Xifeng 
Published: May 2024

Abstract
Tunnel boring machines (TBMs) excavating breezed granite strata produce a lot of muck, including rock powder and gravel. To promote waste recycling and environmentally friendly muck utilization, a series of studies was conducted on the intercity railway section from ShenZhen Airport East Station to HuangMaBu Station in China. First, the muck image dataset was obtained using a camera, and the SAM-YOLO neural network model was adopted to intelligently identify the features of the particle size and content of the muck. Subsequently, the muck was used as an alternative material for the backfill slurry raw material, and the optimal slurry ratio was determined through laboratory tests. Finally, a new backfill slurry was applied on-site. The results demonstrated that the established SAM-YOLO model can accurately and quickly identify muck characteristics, which can be roughly classified by particle size into three categories: rock powder (0-5 mm), gravel (5-10 mm), and crushed rock (10-31.5 mm). Rock powder was utilized to make the monomortar, gravel was used for backfilling, and the crushed rock was broken again to gravel particle size to be used for backfilling. The laboratory test and field application results indicated that the new monomortar can fulfil engineering requirements after the backfilling of gravel, and the optimal water, cement, and rock powder mix ratio is 0.9:1.0:1.0. This research thus provides effective guidance for the utilization of muck in similar projects.
Application of plastic concrete interlocking piles for slope seepage prevention in riprap foundation retaining engineering
Authors: Huang X , Li Z , Li D , Zhen X 
Published: May 2024

Abstract
Based on the foundation pit support project at Shenzhen Shekou cruise center, the application of plastic concrete interlocking piles in slope seepage prevention in a riprap foundation support project near the sea was investigated via finite element analysis. From the characteristics of plastic concrete pile, the modulus of the same, elastic modulus of surrounding riprap foundation, diameter of pile, water level and other factors for slope stability, and influence of plastic concrete pile on slope stability and deformation was obtained. Based on the analysis, key suggestions on the anti-seepage characteristics of plastic concrete pile in slopes were made, and the anti-seepage application of plastic concrete pile in reclamation foundations in airports and power plants were prospected.
Numerical investigation of spudcan penetration in sand with interbedded clay
Authors: Li Tingting , Li Sa , Dai Jialin , Luo Lunbo , Zhai Hanbo 
Published: May 2024

Abstract
Jack-up units are extensively utilized in offshore geotechnical investigations and the recent installation of wind turbine foundations. Engineers require accurate predictions of spudcan penetration resistance to assess its final penetration depth and identify potential risks, e.g., punch-through, ensuring safety during the installation of jack-up units. Notably, for seabed stratigraphy comprising sand with interbedded clay layers, a significant discrepancy exists between the penetration resistance calculated using current industry guidelines and actual measured results. In this study, three-dimensional (3D) large deformation finite-element (LDFE) analyses were performed to model the spudcan penetration response in a seabed consisting of a sand–clay–sand soil profile. A comprehensive parametric study was conducted to examine the influence of soil strength and layer thickness on penetration resistance. The variations of the soil failure mechanisms are demonstrated and associated with the varying penetration resistance, which form the basis of the new calculation method developed for the sand seabed with interbedded clay.
Study on preparation and properties of polyurethane modified epoxy resin lotion cementing slurry
Authors: Mao Chaojing 
Published: May 2024

Abstract
To solve the problems of poor cementing quality and weak consolidation performance of deep-water shallow cementing cement, a low-temperature curable polyurethane-modified epoxy resin lotion (WER) was prepared with epoxy resin and polyurethane as raw materials, and its hydrophilic groups (carboxyl and ether bonds) were self emulsified. The results show that the modified WER lotion cement slurry has good fluidity and stability. Its thickening transition time is less than 16 min, which can effectively prevent gas channeling. In addition, its low-temperature mechanical properties have been significantly improved, and its compressive strength has increased by 42.4% and 44.5% compared to net slurry cement within 3 and 7 days, while its elastic modulus has decreased by 34.1% and 42.4%, respectively.
Effectiveness of dance interventions for falls prevention in older adults: systematic review and meta-analysis
Authors: Lazo Green Kimberly , Yang Yang , Abaraogu Ukachukwu , Eastaugh Claire H , Beyer Fiona R , Norman Gill , Todd Chris 
Published: May 2024

AbstractIntroductionFall prevention is a global health priority. Strength and balance exercise programmes are effective at reducing falls. Emerging literature suggests dance is an enjoyable and sociable form of exercise. However, there is little evidence that dance reduces fall incidence.MethodsSystematic review and meta-analysis examining effectiveness and cost-effectiveness of dance for falls prevention in older adults. Five databases were searched with no restrictions on publication date or intervention settings. Risk of bias was assessed using variants of Cochrane Risk of bias tools, Mixed-Methods Appraisal and Drummond checklist as appropriate. Certainty of evidence was assessed using GRADE.ResultsForty-one studies were included (19 RCTs, 13 quasi-experimental, two mixed-method, seven observational studies, 2,451 participants). Five types of dance interventions were identified: ballroom and Latin dance, dance exercise, cultural dance, dance therapy, and low-impact dance. Meta-analysis was only possible for functional outcome measures: Timed-Up-and-Go (dance versus usual care, mean difference (MD) = 1.36; 95% CI −3.57 to 0.85), Sit-to-Stand (dance versus exercise MD = −0.85; 95% CI −2.64 to 0.93: dance versus education MD = −1.64; 95% CI −4.12 to 0.85), Berg Balance Scale (dance versus usual care MD = 0.61; 95% CI −4.26 to 5.47). There was unexplained variance in effects and no significant differences between intervention and control groups. Overall, certainty of evidence was very low; we are uncertain about the effect of dance interventions in reducing falls.ConclusionsThere is very low certainty evidence for dance as an alternative to strength and balance training if the aim is to prevent falls. No robust evidence on the cost-effectiveness of dance interventions for the prevention of falls was found.PROSPERO registrationCRD42022382908.
Age-associated changes in multimodal pain perception
Authors: Zhi Yongkang , Zhang Yu , Zhang Yu , Zhang Ming , Kong Yazhuo 
Published: May 2024

Abstract

Background
Pain sensitivity varies across multimodal somatosensory stimuli that can rely on different conductive fibres, which, when damaged, will lead to neuropathies. However, there is limited research examining the characteristics of perceived pain, particularly as affected by the ageing process, as induced by various somatosensory stimuli that may rely on small or large fibres.

Methods
Using heat and pressure stimuli on small and large fibres separately on both younger and older adults, this study examined age-associated changes in pain perception by measuring self-reported pain sensitivity, pain threshold and pain discriminability.

Results
Heat pain threshold was significantly positively correlated with age, but not pressure pain threshold. Pain threshold increased and pain discriminability decreased in response to heat stimuli in the older participants compared with the younger ones.

Conclusion
An age-associated decline in heat pain perception was observed, suggesting an earlier degradation of heat perception. These findings provide new insight into understanding and assessing somatosensory disorders, which can help ageing populations better maintain healthy sensory functioning.
The role and limitations of electronic medical records versus patient interviews for determining symptoms of, underlying comorbidities of, and medication use by patients with COVID-19
Authors: Soto Raymond A , Vahey Grace M , Marshall Kristen E , McDonald Emily , Herlihy Rachel , Chun Helen M , Killerby Marie E , Kawasaki Breanna , Midgley Claire M , Alden Nisha B , Tate Jacqueline E , Staples J Erin , Team Colorado Investigation 
Published: May 2024

Abstract
Electronic medical records (EMRs) are important for rapidly compiling information to determine disease characteristics (eg, symptoms) and risk factors (eg, underlying comorbidities, medications) for disease-related outcomes. To assess EMR data accuracy, agreement between EMR abstractions and patient interviews was evaluated. Symptoms, medical history, and medication use among patients with COVID-19 collected from EMRs and patient interviews were compared using overall agreement (ie, same answer in EMR and interview), reported agreement (yes answer in both EMR and interview among those who reported yes in either), and κ statistics. Overall, patients reported more symptoms in interviews than in EMR abstractions. Overall agreement was high (≥50% for 20 of 23 symptoms), but only subjective fever and dyspnea had reported agreement of ≥50%. The κ statistics for symptoms were generally low. Reported medical conditions had greater agreement with all condition categories (n = 10 of 10) having ≥50% overall agreement and half (n = 5 of 10) having ≥50% reported agreement. More nonprescription medications were reported in interviews than in EMR abstractions, leading to low reported agreement (28%). Discordance was observed for symptoms, medical history, and medication use between EMR abstractions and patient interviews. Investigations using EMRs to describe clinical characteristics and identify risk factors should consider the potential for incomplete data, particularly for symptoms and medications.
Volumetric apparent diffusion coefficient histogram analysis in term neonatal asphyxia treated with hypothermia
Authors: Seber Turgut , Uylar Seber Tuğba , Özdemir Ahmet , Baştuğ Osman , Keskin Şuayip , Aktaş Elif 
Published: May 2024

Abstract

Objectives
Our aim is to estimate the long-term neurological sequelae and prognosis in term neonatal asphyxia treated with hypothermia via volumetric apparent diffusion coefficient (ADC) map histogram analysis (HA).

Methods
Brain MRI studies of 83 term neonates with asphyxia who received whole-body hypothermia treatment and examined between postnatal (PN) fourth and sixth days were retrospectively re-evaluated by 2 radiologists. Volumetric HA was performed for the areas frequently affected in deep and superficial asphyxia (thalamus, lentiform nucleus, posterior limb of internal capsule, corpus callosum forceps major, and perirolandic cortex-subcortical white matter) on ADC map. The quantitative ADC values were obtained separately for each region. Qualitative-visual (conventional) MRI findings were also re-evaluated. Neonates were examined neurodevelopmentally according to the Revised Brunet-Lezine scale. The distinguishability of long-term neurodevelopmental outcomes was statistically investigated.

Results
With HA, the adverse neurodevelopmental outcomes could only be distinguished from mild-moderated impairment and normal development at the thalamus with 10th percentile ADC (P = .02 and P = .03, respectively) and ADCmin (P = .03 and P = .04, respectively). Also with the conventional MRI findings, adverse outcome could be distinguished from mild-moderated impairment (P = .04) and normal development (P = .04) via cytotoxic oedema of the thalamus, corpus striatum, and diffuse cerebral cortical.

Conclusion
The long-term adverse neurodevelopmental outcomes in newborns with asphyxia who received whole-body hypothermia treatment can be estimated similarly with volumetric ADC-HA and the conventional assessment of the ADC map.

Advances in knowledge
This study compares early MRI ADC-HA with neurological sequelae in term newborns with asphyxia who received whole-body hypothermia treatment. We could not find any significant difference in predicting adverse neurological sequelae between the visual-qualitative evaluation of the ADC map and HA.
95 MODIFIED HISTOPATHOLOGICAL GRADING OPTIMIZES PREDICTION OF SURVIVAL OUTCOMES IN SMALL INTESTINAL NEUROENDOCRINE TUMOURS
Authors: Daskalakis K , Tsoli M , Wallin G , Kogut A , Srirajaskanthan R , Giovos G , Weickert M O , Kos-Kudla B , Kaltsas G 
Published: May 2024

Abstract

Background
We aimed to identify optimal grading Ki-67 cut-offs to delineate differences in prognosis of patients with small intestinal neuroendocrine tumours (SI-NETs) in terms of overall- and event-free survival rates.

Methods
We included 551 patients with SI-NETs diagnosed from June 15th, 1993, through March 8th, 2021, identified using the SI-NET databases from five European referral centers.

Results
Median age at baseline was 62.3(17-90) years; 252 patients were women (45.7%). All tumours were well-differentiated; 326 were G1 tumours (59.2%), 169 G2(30.7%), only 8 G3(1.5%), while 48 tumours were of unspecified grade(8.7%). The median Ki67 was 2%(1-70%). 247 patients(44.8%) had distant metastases at baseline (stage IV), 217 locoregional disease(41.1%; stage III), whereas 29(7.1%) and 25(4.5%) presented at stages II and I, respectively. Within a mean(SD) follow-up of 51.5(52.9) months, 94 patients(17.1%) died, whereas overall 188 experienced disease recurrence, progression and/or death(34.1%). The median OS was 214.7(95%CI: 152.7-276.6) months and the median EFS was 79.8(95%CI: 68.2-91.5) months, respectively. In multivariable Cox-regression OS analysis, age (HR=1.07, 95%CI: 1.04-1.09; p&lt;0.001), Charlson Comorbidity Index(HR=1.1, 95%CI: 1.03-1.17; p=0.006) and the proposed modified histopathological Ki67 grading system(K67:5-10% group: HR=2.4, 95%CI: 1.3-4.5; p=0.007 and K67≥10% group: HR=5.1, 95%CI: 2.9-9.2; p&lt;0.001) were independent predictors for death. Pertinent EFS analysis, confirmed age(HR=1.04, 95%CI: 1.02-1.05;p&lt;0.001) and the proposed modified histopathological Ki67 grading system(K67≥10% group: HR=4; 95%CI:2.5-6.2;p&lt;0.001) as independent predictors for recurrence, progression and/or death.

Conclusions
Ki-67 proliferation index is an independent predictor of EFS and OS. A modified site-specific histopathological grading system applying Ki-67 cut-offs of 5% and 10% seems more optimal to predict differences in SI-NET patient prognosis.
127 CATECHOLAMINE-INDUCED HYPERTENSIVE CRISIS DURING LAPAROSCOPIC ADRENALECTOMY FOR UNILATERAL PHEOCHROMOCYTOMA
Authors: Criqui C N , Nguyen-Thi P L , Duclos A , Polazzi S , Haythem Najah N , Gaujoux S , Fabrice M , Mirallié E , Sebag F , Zinzindoue F , Lifante J C , Brunaud L 
Published: May 2024

Abstract

Background
Laparoscopic adrenalectomy (LA) is the standard of care for the management of pheochromocytoma after preoperative medical preparation (PMP) using antihypertensive medications. Catecholamine-induced hypertensive crisis (CIHC) was recently defined by an international consortium as blood pressure &gt; 180/120 mmHg. However, the impact of PMP on intraoperative CIHC and perioperative complications remains controversial. The aim of this study was to evaluate the impact of PMP on the incidence of intraoperative CIHC and perioperative complications.

Methods
Multi-institutional retrospective cohort study including data from all patients who underwent LA for pheochromocytoma in 8 high-volume surgical departments from 01/01/2000 to 12/31/2016. Patients who underwent emergency surgery, bilateral or open adrenalectomy were excluded (n=140).

Results
Data were available for 922 patients (female n=520, 56.4%). Long-term antihypertensive treatment prior surgery and specific PMP were recorded in 479 (51.9%) and 604 patients (65.5%), respectively. During LA, at least one episode of CIHC was observed in 123 patients (13.7%). Perioperative mortality rate was 0.3% (3 patients). Thirty-day postoperative complication rate was 20.4% (188 patients). In multivariable analysis, tumor size (0.99, 0.98-1.00; p=0.04) remained the only independent predictor for intraoperative CIHC incidence (ASA score, long-term antihypertensive treatment, and PMP had no significant impact). ASA score (2.17, 1.56-3.01; p&lt;0.001), tumor size (1.01, 1.00-1.02; p&lt;0.01), long-term antihypertensive treatment (1.59, 1.11-2.28; p=0.01), and intraoperative CIHC incidence (0.62, 0.39-0.97; p=0.03) remained independent predictors for perioperative complications, but not PMP.

Conclusions
The use of PMP had no significant impact on intraoperative CIHC incidence and perioperative complications in this multi-institutional cohort study.
146 NEOADJUVANT SYSTEMIC THERAPY FOR “INOPERABLE” THYROID CANCERS: SURGICAL RESECTION STRATEGIES
Authors: Dickerson K , Niu J , Metzger R , Tomeh C , Ahmad I , Hebert M , Nasr C , Nelson J , Westfall E , Eisen R , Milas M 
Published: May 2024

Abstract

Background
Limited treatment options exist for “inoperable” thyroid cancers. Neoadjuvant (NEO) use of systemic tyrosine kinase inhibitors (TKI) has been anecdotally reported. We aimed to evaluate whether NEO-TKI therapy facilitates surgical resection.

Methods
Single-institution experience of patients receiving TKI for papillary (PTC), follicular (FTC) and anaplastic thyroid carcinomas (ATC) during 2018-2023 was reviewed. Our center has a well-established multidisciplinary pathway with protocol-driven management of advanced thyroid cancers. TKI regimens included dabrafenib/trametinib, lenvatinib/pembrolizumab or lenvatinib alone.

Results
10/42 patients (median age 56 years) received NEO-TKI with intent to improve resectability of primary (n=5, 2 FTC/3 PTC) or recurrent tumors (n=5, 1 ATC/4 PTC). All had locoregionally advanced disease: CT size 9±2.6 cm with lymphadenopathy (n=9) and vital structure involvement (n=8). All were “inoperable” or resectable with unacceptable morbidities. Genomic analysis detected BRAF V600E mutation in 1/1 ATC and 6/7 PTC, and NRAS/TERT or HRAS/TERT in both FTC. NEO-TKI yielded clinical results quickly, including mass reduction and cessation of hemoptysis from tracheal invasion. Seven patients received intended surgery with R0 resection and without major surgical complications. Patients tolerated NEO-TKI well with minimal toxicity. Two years post-operatively, all patients are alive without new locoregional recurrence.

Conclusions
NEO-TKI seems extremely effective in downstaging surgically “inoperable” thyroid cancers to achieve R0 resection while avoiding unnecessary morbidities. Multidisciplinary approach with early genomic profiling to guide personalized NEO-TKI is essential. Prospective studies using NEO-TKI are urgently needed as this series suggests neoadjuvant therapy may have a significant role in future surgical resection strategies for thyroid cancers.
75 CIRCULATING EXTRACELLULAR VESICLES AS DIAGNOSTIC BIOMARKERS FOR INDETERMINATE THYROID NODULES
Authors: Ahmed N , Beatson K , Patel J , Eddama M , Abdel-Aziz T , Clapp L 
Published: May 2024

Abstract

Background
Preoperative differentiation of benign from malignant indeterminate thyroid nodules (ITN) remains one of the most challenging issues in endocrine oncology. Most patients with an ITN will undergo diagnostic surgery with around 80% receiving a benign diagnosis on final histology. Liquid biopsy-based analysis of circulating extracellular vesicles (EVs) presents a promising diagnostic modality. The objective of this study is to measure the plasma levels of circulating EVs and identifying differentially expressed EV miRNAs in patients with benign versus malignant ITNs.

Methods
To quantify EVs: EVs where isolated by differential centrifugation from plasma of 28 patients with ITN (14 benign and 14 cancers on histology) and 16 matched healthy controls (HCs). The total and subpopulations of cancer related EVs (CXCR7+, CD147+, SDC4+, EpCAM+) were measured using a scatter calibrated flow cytometer. For miRNA sequencing: plasma EVs were isolated, and EV-RNA extracted using exoRNeasy Midi kit (Qiagen) from 3 HCs, 6 benign and 9 cancer patients. Sequencing was performed using DNBseq-G400 sequencer (BGI).

Results
The total plasma EV levels as well as CXCR7+, CD147+, SDC4+, EpCAM+ EVs were significantly higher in patients with ITN (both cancer and benign) compared to HCs (p&lt;0.0001 for all). Two miRNAs (hsa-miR-195-3p, hsa-miR-619-5p) were significantly upregulated (p&lt;0.0001) and 4 were downregulated: hsa-miR-3176, hsa-miR-205-5p, a novel miRNA: hsa-miR208-3p (p&lt;0.0001 for all 3), and hsa-let-7i-3p (p=0.03) in patients with malignant versus benign ITNs

Conclusions
Circulating EVs, especially EV miRNAs, have a high diagnostic value and may improve the diagnostic strategy for patients with ITNs.