bluuebunny/crossref_metadata_2025_split huggingface dataset:
ChemInform Abstract: Stannylated Allyl Carbonates as Versatile Building Blocks for the Diversity‐Oriented Synthesis of Allylic Amines and Amides.
Authors: Bukovec Christian , Kazmaier Uli 
Published: July 2011

Abstractα‐Stannylated allylic carbonates (I) smoothly undergo Pd‐catalyzed amination to give the corresponding stannylated allylic amines (III), which are suitable substrates for Pd‐catalyzed Stille coupling reactions [cf.
ChemInform Abstract: Enantioselective Construction of Quaternary Stereogenic Centers from Tertiary Boronic Esters: Methodology and Applications.
Authors: Sonawane Ravindra P. , Jheengut Vishal , Rabalakos Constantinos , Larouche‐Gauthier Robin , Scott Helen K. , Aggarwal Varinder K. 
Published: July 2011

AbstractTertiary boronic esters are successfully converted into the homologated alcohols (III) under standard Matteson conditions with complete retention of configuration.
ChemInform Abstract: Influence of CH3 Substituents in Tetrahydropyrimidin‐2‐ylidene: σ‐Donating Properties and in situ Catalytic Activities of Precursor Salts/Pd(OAc)2 System for C—C Coupling Reactions.
Authors: Mercan Deniz , Cetinkaya Engin , Cetinkaya Bekir 
Published: July 2011

AbstractSymmetrical (I) and unsymmetrical 1,3‐dialkyltetrahydropyrimidinium salts containing two methyl groups at position 5 (II) are prepared and studied in model Heck—Mizoroki and Suzuki cross coupling reactions.
ChemInform Abstract: 1,3‐Diynes Synthesis by Homo‐Coupling of Terminal Alkynes Using a Pd(PPh3)4/Ag2O Simple Catalyst System.
Authors: Feng Xiujuan , Zhao Ziran , Yang Fan , Jin Tienan , Ma Yongjie , Bao Ming 
Published: July 2011

AbstractAmine‐ and copper‐free Pd‐catalyzed homocoupling of terminal alkynes proceeds efficiently in the presence of silver oxide, which serves as both promoter and oxidant.
ChemInform Abstract: Novel Reaction in the Chemistry of Organoaluminum Compounds.
Authors: Ishmuratov G. Yu. , Vydrina V. A. , Yakovleva M. P. , Valeeva E. F. , Muslukhov R. R. , Tolstikov G. A. 
Published: July 2011

AbstractO‐isobutyl derivatives (III) and (V) are obtained by low temperature treatment of corresponding lactones (I) and (IV) with iBu2AlH.
ChemInform Abstract: 3,4‐Dihalo‐2(5)‐furanones: A Novel Oxidant for the Glaser Coupling Reaction.
Authors: Li Jian‐Xiao , Liang Hao‐Ran , Wang Zhao‐Yang , Fu Jian‐Hua 
Published: July 2011

AbstractThe new variant of the Glaser coupling provides easy and efficient access to alkyl and aryl‐substituted 1,3‐diyne compounds.
ChemInform Abstract: Tandem Insertion of Halocarbenoids and Lithium Acetylides into Zirconacycles: A Novel Rearrangement to Zirconium Alkenylidenates by β‐Addition to an Alkynyl Zirconocene.
Authors: Stec Jozef , Thomas Emma , Dixon Sally , Whitby Richard J. 
Published: July 2011

AbstractZirconocene complexes are used in the present one‐pot three‐component synthesis of carbocycles.
ChemInform Abstract: Application of a Metathesis Reaction in the Synthesis of Sterically Congested Medium‐Sized Rings. A Direct Ring Closing versus a Double Bond Migration—Ring Closing Process.
Authors: Michalak Michal , Wicha Jerzy 
Published: July 2011

AbstractSterically congested trans‐cycloalkylidene‐tethered 1,9‐dienes can undergo either direct RCM reaction or a double bond migration—RCM domino reaction in the presence of Grubbs′ second generation catalyst.
ChemInform Abstract: Facile Preparation of Bicyclo[2.2.2]octenone Derivatives via Diels—Alder Cycloadditions of in situ‐Generated Masked o‐Benzoquinones.
Authors: Kalogiros Christos , Hadjiarapoglou Lazaros P. 
Published: July 2011

AbstractThe title cycloaddition provides easy access to highly substituted bicyclo[2.2.2]oct‐5‐en‐2‐ones.
ChemInform Abstract: Enantioselective Synthesis of Alkyne‐Substituted Quaternary Carbon Stereogenic Centers Through NHC—Cu‐Catalyzed Allylic Substitution Reactions with (iBu)2(Alkynyl)aluminum Reagents.
Authors: Dabrowski Jennifer A. , Gao Fang , Hoveyda Amir H. 
Published: July 2011

AbstractThe enantioselective synthesis of small organic molecules containing readily differentiable alkyne and alkene groups such as (III) is described.
ChemInform Abstract: Rhodium‐Catalyzed Highly Enantioselective Addition of Arylboronic Acids to 2‐Nitrostyrenes by tert‐Butanesulfinylphosphine Ligand.
Authors: Lang Feng , Chen Guihua , Li Liangchun , Xing Junwei , Han Fuzhong , Cun Linfeng , Liao Jian 
Published: July 2011

AbstractBased on the title method, the first asymmetric synthesis of cherylline (VI) is reported.
ChemInform Abstract: Direct Electrochemical Imidation of Aliphatic Amines via Anodic Oxidation.
Authors: Zhang Li , Su Ji‐Hu , Wang Sujing , Wan Changfeng , Zha Zhenggen , Du Jiangfeng , Wang Zhiyong 
Published: July 2011

AbstractA new, promising electrochemical strategy for the synthesis of sulfonyl amidine derivatives is developed.
ChemInform Abstract: Propylphosphonic Anhydride (T3P®)‐Mediated One‐Pot Rearrangement of Carboxylic Acids to Carbamates.
Authors: Augustine John Kallikat , Bombrun Agnes , Mandal Ashis Baran , Alagarsamy Padma , Atta Rajendra Nath , Selvam Panneer 
Published: July 2011

AbstractT3P as condensing agent in combination with trimethylsilylazide and triethylamine provides a practical method for the direct conversion of a broad range of carboxylic acids and alcohols to carbamates.
ChemInform Abstract: Convenient Synthesis of 2‐Imino‐3‐(2‐thienyl)‐2(5H)‐furans and Their Certain Transformations.
Authors: Avetisyan A. A. , Alvandzhyan A. G. , Avetisyan K. S. 
Published: July 2011

AbstractCompounds (III) can be easily hydrolyzed to the corresponding lactones under protic conditions.
ChemInform Abstract: Formation of Five‐Membered Cyclic Orthoesters from Tribromides with Participation of a Neighboring Carbonyl Group.
Authors: Gururaja Guddeangadi N. , Mobin Shaikh M. , Namboothiri Irish N. N. 
Published: July 2011

AbstractDepending on the workup conditions, the alcoholysis of keto tribromides (III) affords either unexpected dihydrofuran derivatives under neutral workup conditions, or the expected γ‐keto esters by acidic workup of the reaction mixture.
ChemInform Abstract: One‐Pot Synthesis of 5‐Amino‐4‐cyano Pyrrole Derivatives.
Authors: Nishio Yukihiro , Kimura Hidenori , Uchiyama Katsuya , Horiuchi Yoshihiro , Nakahira Hiroyuki 
Published: July 2011

AbstractIn continuation of a research on novel dipeptidyl peptidase IV inhibitors for the treatment of type‐2 diabetes, a one‐pot synthesis of title compounds starting from dicyanoketene dithioacetal (I) is developed.
ChemInform Abstract: Copper‐Catalyzed Direct Synthesis of 3‐Arylindoles.
Authors: Murru Siva , Gallo August A. , Srivastava Radhey S. 
Published: July 2011

AbstractBy use of a Cu(II)—Cu(0) catalytic system, nitrosoarenes and alkynes undergo an annulation/deoxygenation reaction to give the desired indoles.
ChemInform Abstract: Catalytic Asymmetric Synthesis of 3‐Hydroxy‐2‐oxindoles via Enantioselective Morita—Baylis—Hillman Reaction of Isatins.
Authors: Wang Ci‐Ci , Wu Xin‐Yan 
Published: July 2011

AbstractThe reaction is best catalyzed by the (diphenylphosphino)(cyclohexyl)‐phenylthiourea and is applied to the various acrylates (II), (IV), acrolein (VIIIa) and methyl vinyl ketone (VIIIb).
ChemInform Abstract: Metal—Ligand Bifunctional Activation and Transfer of N—H Bonds.
Authors: Muniz Kilian , Lishchynskyi Anton , Streuff Jan , Nieger Martin , Escudero‐Adan Eduardo C. , Martinez Belmonte Marta 
Published: July 2011

AbstractAn enantioselective aza‐Michael reaction for the preparation of a series of indoline amino acid esters (II) and (IV) from corresponding alkenes (I) and (III), resp., is elaborated using well defined ruthenium sulfonamide complexes as catalyst.
ChemInform Abstract: Synthesis and Anticonvulsant Properties of 1‐(Amino‐N‐arylmethanethio)‐3‐(1‐substituted benzyl‐2,3‐dioxoindolin‐5‐yl) Urea Derivatives.
Authors: Siddiqui Nadeem , Alam M. Shamsher , Stables James P. 
Published: July 2011

AbstractThe derivatives (I) are found to possess potent anticonvulsant properties and no significant neurotoxicity.
ChemInform Abstract: Palladium‐Catalyzed Three‐Component Reaction of 2,3‐Allenyl Amines, Isocyanates, and Organic Halides: A Diversified Assembly of Imidazolidinones.
Authors: Shu Wei , Yu Qiong , Jia Guochen , Ma Shengming 
Published: July 2011

AbstractVarious substituted imidazole derivatives are efficiently synthesized by the present new three‐component reaction of allenyl amines with isocyanates and organic iodides under mild conditions.
ChemInform Abstract: Carbene‐Mediated Transformations of 1‐(Benzylideneamino)benzimidazoles.
Authors: Katritzky Alan R. , Jishkariani Davit , Sukhuja Rajeev , Hall C. Dennis , Steel Peter J. 
Published: July 2011

AbstractTreatment of the ammonium salts (III) with NaH/CS2 and NaH/Bz‐NCS results in formation of the corresponding betaines (V) and (VII).
ChemInform Abstract: Ketenimine N‐Functionalization of Thiazolidine‐3,4‐diones with Acetylenes and Isocyanides.
Authors: Yavari Issa , Sanaeishoar Tayebeh , Azad Leila , Ghazvini Maryam 
Published: July 2011

AbstractThe three‐component one‐pot reaction of thiazolidinediones with alkyl isocyanides and dialkyl acetylenedicarboxylates gives highly functionalized stable ketenimines.
ChemInform Abstract: Highly Enantioselective Direct Michael Addition of 1H‐Benzotriazole to Chalcones Catalyzed by Sc(OTf)3/N,N′‐Dioxide Complex.
Authors: Wang Jing , Wang Wentao , Liu Xiaohua , Hou Zongrui , Lin Lili , Feng Xiaoming 
Published: July 2011

AbstractThe optimized reaction affords N‐1 substituted benzotriazoles in excellent yields and enantioselectivities.
ChemInform Abstract: Synthesis of N‐Fmoc‐Protected Amino Alkyl Thiocyanates/Selenocyanates and Their Application in the Preparation of 5‐Substituted S/Se‐Linked Tetrazoles.
Authors: Sureshbabu Vommina , Vasantha Basavalingappa , Hemantha Hosahalli P. 
Published: July 2011

AbstractA facile conversion of N‐Fmoc amino alkyl iodides to the corresponding thiocyanates or selenocyanates is developed.
ChemInform Abstract: Reactions of 3‐Aminoisoxazolo[4,5‐c]coumarin with Benzoyl Chloride: The First Example of a Preparative 1,2,4‐Oxadiazole—Oxazole Rearrangement.
Authors: Sosnovskikh Vyacheslav Ya. , Moshkin Vladimir S. , Kornev Mikhail Yu. , Kodess Mikhail I. 
Published: July 2011

AbstractBenzoylation of isoxazole fused coumarin (I) is accompanied by a Boulton—Katrizky rearrangement resulting in 1,2,4‐oxadiazole derivatives (III) and (V), respectively.
ChemInform Abstract: Facile Regioselective Synthesis of Benzofuran‐Annulated Six‐Membered Sulfur Heterocycles and the Occurrence of Thermal [1,3] Sigmatropic Rearrangement.
Authors: Majumdar Krishna C. , Nath Sanjay , Chattopadhyay Buddhadeb , Ray Krishanu 
Published: July 2011

AbstractPhase transfer catalyzed alkylation of benzofuranthione (I) with propargyl halides affords the corresponding S‐alkyl derivatives, which undergo thio‐Claisen rearrangement under mild conditions to give hitherto unreported sulfur heterocycles [cf.
ChemInform Abstract: Transition Metal‐Catalyzed Cross Coupling with N‐Acyliminium Ions Derived from Quinolines and Isoquinolines.
Authors: Graham Thomas J. A. , Shields Jason D. , Doyle Abigail G. 
Published: July 2011

AbstractThe new protocol allows the assembly of 2‐aryl‐substituted dihydroquinolines such as (III) and (IX) as well as 1‐arylated dihydroisoquinolines (VI) under mild reaction conditions employing a nickel catalyst.
ChemInform Abstract: Pd2I2/I2‐Catalyzed Thiolation‐Annulation of 2‐Alkynylbenzyl Azides with Disulfides: Selective Synthesis of 4‐Sulfenylisoquinolines.
Authors: Zhang Hong‐Ping , Yang Xu‐Heng , Peng Peng , Li Jin‐Heng 
Published: July 2011

AbstractThe reaction produces a series of 4‐chalcogen‐substituted isoquinolines.
ChemInform Abstract: Synthesis of C3‐Nitroalkylated‐4‐hydroxycoumarin and Hydroxyiminodihydrofuroquinolinone Derivatives via the Michael Addition of Cyclic 1,3‐Dicarbonyl Compounds to β‐Nitrostyrenes.
Authors: Barange Deepak Kumar , Kavala Veerababurao , Kuo Chun‐Wei , Lei Po‐Min , Yao Ching‐Fa 
Published: July 2011

AbstractA variety of 3‐substituted 4‐hydroxycoumarin derivatives is prepared in high yields from 4‐hydroxycoumarine (I) and aromatic nitroalkenes [cf.
ChemInform Abstract: Enantioselective Organocatalyzed Cascade Reactions to Highly Functionalized Quinolizidines.
Authors: Dai Xiaoyang , Wu Xiaoyu , Fang Huihui , Nie Linlin , Chen Jie , Deng Hongmei , Cao Weiguo , Zhao Gang 
Published: July 2011

AbstractA prolinol‐derived silyl ether efficiently catalyzes the one‐pot Michael addition/Pictet—Spengler reaction of β‐ketoamides with α,β‐unsaturated aldehydes.
ChemInform Abstract: A New Diversity Oriented and Metal‐Free Approach to Highly Functionalized 3H‐Pyrimidin‐4‐ones.
Authors: Riva Renata , Banfi Luca , Basso Andrea , Zito Paola 
Published: July 2011

AbstractA new, convergent and combinatorial four‐step synthesis of pyrimidin‐4‐ones from easily available β‐ketoesters is reported.
ChemInform Abstract: Synthesis and Photophysical Properties of Alkynylated Pyrimidines by Site‐Selective Sonogashira Reactions of 2,4,5,6‐Tetrachloropyrimidine; First Synthesis of Tetraalkynyl‐pyrimidines.
Authors: Malik Imran , Ahmed Zeeshan , Reimann Sebastian , Ali Iftikhar , Villinger Alexander , Langer Peter 
Published: July 2011

AbstractThe di‐, tri‐ and tetraalkynyl‐pyrimidines exhibit fluorescence in the range of 395‐470 nm.
ChemInform Abstract: Enantioselective Synthesis Induced by Compounds with Chirality Arising from Partially Deuterated Methyl Groups in Conjunction with Asymmetric Autocatalysis.
Authors: Kawasaki Tsuneomi , Ozawa Hitomi , Ito Masateru , Soai Kenso 
Published: July 2011

AbstractThe use of less amounts of the catalyst leads to moderate enantiomeric excess of the product.
ChemInform Abstract: A New and Efficient Method for the Synthesis of Bromosilanes from Hydrosilanes Using Br3CCOOEt/PdCl2 as the Catalyst.
Authors: Srithanakit Phatsupha , Chavasiri Warinthorn 
Published: July 2011

AbstractThe method is extended to a one‐pot synthesis of triisopropylsilyl ethers and triisopropyl esters.
ChemInform Abstract: Synthesis of Cyclopropane‐Containing Phosphorus Compounds by Radical Coupling of Butenylindium with Iodo Phosphorus Compounds.
Authors: Kiyokawa Kensuke , Suzuki Itaru , Yasuda Makoto , Baba Akio 
Published: July 2011

AbstractThe butenylindium species generated by transmetalation between stannane (I) and InBr3 reacts with α‐ or β‐iodo phosphorus compounds (II) or (IV) either by thermal heating or under UV irradiation to give the desired cyclopropylalkylphosphorus products.
ChemInform Abstract: Ionic Liquid Promoted Synthesis, Antibacterial and in vitro Antiproliferative Activity of Novel α‐Aminophosphonate Derivatives.
Authors: Dake Satish A. , Raut Dnyaneshwar S. , Kharat Kiran R. , Mhaske Rooth S. , Deshmukh Satish U. , Pawar Rajendra P. 
Published: July 2011

AbstractNovel α‐aminophosphonates (IV) are obtained via three‐component one‐pot reaction catalyzed by ethylammonium nitrate which also acts as ionic liquid solvent.
ChemInform Abstract: Regioselective Synthesis of Functionalized Ferrocenylphenols Based on Cyclocondensation Reactions of Free and Masked 1,3‐Dicarbonyl Dianions.
Authors: Bendrath Franziska , Villinger Alexander , Langer Peter 
Published: July 2011

AbstractReaction of ferrocenyl‐bis(methylthio)propenones (I) with masked dicarbonyldianions (II) proceeds with initial 1,2‐addition to give ferrocenylphenols (III) as single regioisomers.
ChemInform Abstract: Synthesis of (E)‐2‐(1‐Ferrocenylmethylidene)malonic Acid Derivatives by a Cobalt‐Catalyzed Domino Reaction of Ethyl Diazoacetate, Carbon Monoxide and Ferrocenylimines.
Authors: Balogh Janos , Kegl Tamas , Parkanyi Laszlo , Kollar Laszlo , Ungvary Ferenc , Skoda‐Foeldes Rita 
Published: July 2011

AbstractCobalt‐catalyzed domino reaction of ferrocenylimines (I) with diazoacetate (II) and carbon monoxide (III) provides access to ferrocenylmethylene amidocarboxylates (IV)/(V).
ChemInform Abstract: Aza‐Annulation on the 16‐Dehydropregnenolone, via Tandem Intermolecular Aldol Process and Intramolecular Michael Addition.
Authors: Kumar Manmeet , Rawat Preeti , Khan Mohammad Faheem , Rawat Arun Kumar , Srivastava Arvind Kumar , Maurya Rakesh 
Published: July 2011

AbstractThe aza‐annulation to pentacyclic pregnenolone derivatives (VII), based on both Michael addition and aldol condensation, represents a new type of cyclization in steroid chemistry.
ChemInform Abstract: Inhibition of Nitric Oxide Production in Lipopolysaccharide‐Stimulated RAW264.7 Macrophage Cells by Lignans Isolated from Euonymus alatus Leaves and Twigs.
Authors: Jeong Eun Ju , Cho Jung Hee , Sung Sang Hyun , Kim Sun Yeou , Kim Young Choong 
Published: July 2011

AbstractThe new lignans (I) and (II) are isolated together with several known other lignans from leaves and twigs.
ChemInform Abstract: Asymmetric Total Synthesis of (+)‐ and (‐)‐Clusianone and (+)‐ and (‐)‐Clusianone Methyl Enol Ether via ACC Alkylation and Evaluation of Their anti‐HIV Activity.
Authors: Garnsey Michelle R. , Matous James A. , Kwiek Jesse J. , Coltart Don M. 
Published: July 2011

AbstractThe first asymmetric total synthesis of (‐)‐clusianone (I) via Effenberger cyclization is described.
ChemInform Abstract: Antitumor Agents. Part 287. Substituted 4‐Amino‐2H‐pyran‐2‐one (APO) Analogues Reveal a New Scaffold from Neo‐Tanshinlactone with in vitro Anticancer Activity.
Authors: Dong Yizhou , Nakagawa‐Goto Kyoko , Lai Chin‐Yu , Morris‐Natschke Susan L. , Bastow Kenneth F. , Lee Kuo‐Hsiung 
Published: July 2011

AbstractTitle compounds (I) are designed and synthesized as a new class of in vitro anticancer agents.
ChemInform Abstract: Design, Synthesis and Structure—Activity Relationships of (Indo‐3‐yl) Heterocyclic Derivatives as Agonists of the CB1 Receptor. Discovery of a Clinical Candidate.
Authors: Ratcliffe Paul , et al. et al. 
Published: July 2011

AbstractThe expansion of the SAR of a novel series of indole‐3‐heterocyclic CB1 receptor agonists is reported.
ChemInform Abstract: Catalytic (Ni, Pd, Pt, Rh and Au) and Non‐Catalytic Reactions for Atom‐Economic Carbon—Sulfur, Carbon—Selenium, and Carbon—Tellurium Bonds Formation
Authors: Ananikov Valentine P. , Zalesskiy Sergey S. , Beletskaya Irina P. 
Published: July 2011

AbstractReview: 233 refs.
ChemInform Abstract: Synthesis of Furanoid and Pyranoid Sugar α‐ and β‐Amino Acids and Related Aminocycloalkanecarboxylic Acids from Carbohydrates
Authors: Soengas Raquel G. , Estevez Amalia M. , Estevez Juan C. , Estevez Ramon J. 
Published: July 2011

AbstractReview: 115 refs.
ChemInform Abstract: Synthesis of Iminosugars via 1,3‐Dipolar Cycloaddition Reactions of Nitrones to α,β‐Unsaturated Sugar Aldonolactones
Authors: Stecko Sebastian , Jurczak Margarita , Panfil Irma , Furman Bartlomiej , Grzeszczyk Barbara , Chmielewski Marek 
Published: July 2011

AbstractReview: 230 refs.
Pulmonary function after whole lung irradiation in pediatric patients with solid malignancies
Authors: Motosue Megan S. , Zhu Liang , Srivastava Kumar , Stokes Dennis C. , Hudson Melissa M. , McPherson Valerie , Srinivasan Saumini , Krasin Matthew J. , Green Daniel M. , Spunt Sheri L. , Inaba Hiroto 
Published: July 2011

AbstractBACKGROUND:Although whole lung irradiation is used to treat pulmonary metastases of pediatric solid malignancies, few studies have addressed its long‐term pulmonary consequences.METHODS:The authors conducted a retrospective study of longitudinal changes in 171 pulmonary function tests (PFTs) and their relation with clinical features in 48 survivors of pediatric malignant solid tumors treated with whole lung irradiation.RESULTS:Although active respiratory symptoms were seen in only 9 patients (18.8%), abnormalities in forced vital capacity (FVC; 58.3%), forced expiratory volume in 1 second (FEV1; 64.6%), total lung capacity (TLC; 72.9%), and diffusion capacity of the lung for carbon monoxide corrected for hemoglobin (DLCOcorr; 70.8%) were common. At a median follow‐up of 9.7 years after whole lung irradiation, FVC, FEV1, and TLC significantly declined longitudinally (P = .04, .03, and .02, respectively). Focal pulmonary boost irradiation was significantly associated with abnormal FEV1/FVC (P = .03), forced expiratory flow between 25% and 75% forced vital capacity (P = .005), residual volume (RV; P = .005), and RV/TLC (P = .002). Ten patients had baseline PFTs, and FVC, FEV1, TLC, and DLCOcorr worsened immediately after radiation, followed by transient improvement but subsequent decline. Thirteen of 32 (40.6%) patients aged >18 years were smokers.CONCLUSIONS:Pulmonary dysfunction was prevalent after whole lung irradiation and worsened over time, although most patients were asymptomatic. Boost irradiation impaired pulmonary function, and a significant proportion of patients were smokers. Further studies are planned to assess the predictors and clinical consequences of progressive PFT abnormalities and to evaluate educational interventions. Cancer 2012;. © 2011 American Cancer Society.
Expression of focal adhesion kinase in small‐cell lung carcinoma
Authors: Ocak Sebahat , Chen Heidi , Callison Clay , Gonzalez Adriana L. , Massion Pierre P. 
Published: July 2011

AbstractBACKGROUND:The focal adhesion kinase (FAK) is a non‐receptor tyrosine kinase linked to tumor growth, invasion, and metastasis. FAK is overexpressed and associated with prognosis in many cancers, but its prognostic value in small‐cell lung carcinoma (SCLC) is unknown and was the focus of this study.METHODS:Total FAK expression was analyzed via immunohistochemistry in tissue microarrays consisting of formalin‐fixed, paraffin‐embedded SCLC specimens from 85 patients. FAK staining scores were tested for correlations with pathological characteristics and clinical outcomes. Phospho‐paxillin was also tested in 35 of the 85 specimens to evaluate whether FAK expression was associated with downstream signaling.RESULTS:Specific FAK expression was localized to the cytoplasm of 78/85 (92%) SCLCs. FAK expression was scored low in 11 (13%), moderate in 17 (20%), and high in 50 (59%) SCLCs. FAK staining scores treated as continuous variables did not correlate with SCLC disease stage, response to therapy, recurrence/progression‐free survival, or overall survival. Moreover, total FAK expression did not correlate with phospho‐paxillin Tyr118 expression.CONCLUSIONS:Total FAK is strongly expressed in a majority of SCLC tumors. However, the expression evaluated via immunohistochemistry is not a prognostic factor in patients with SCLC. Cancer 2012;. © 2011 American Cancer Society.