bluuebunny/crossref_metadata_2025_split huggingface dataset:
Australian Natural History Series: Albatrosses. Terence Lindsey.
Authors: Wisniewski Samantha S. 
Published: April 2009

Australian Natural History Series: Great Whales. John Bannister. 2008. CSIRO Publishing, Collingwood, Victoria, Australia. 142 pp. $27.45. ISBN: 978‐0‐64309‐373‐7 (softcover).Australian Natural History Series: Platypus. Fourth Edition. Tom Grant, illustrated by Dominic Fanning. 2008. CSIRO Publishing, Collingwood, Victoria, Australia. 159 pp. $27.45. ISBN: 978‐0‐64309‐370‐6 (softcover).
Common Variation in SIM1 Is Reproducibly Associated With BMI in Pi ma Indians
Authors: Traurig Michael , Mack Janel , Hanson Robert L. , Ghoussaini Maya , Meyre David , Knowler William C. , Kobes Sayuko , Froguel Philippe , Bogardus Clifton , Baier Leslie J. 
Published: April 2009

OBJECTIVE
Haploinsufficiency of SIM1 is a cause of rare monogenic obesity. To assess the role of SIM1 in polygenic obesity, this gene was analyzed in the Pima Indian population, which has a high prevalence of obesity.

RESEARCH DESIGN AND METHODS
SIM1 was sequenced in 96 individuals. Variants (n = 46) were genotyped in a population-based sample of 3,250 full-heritage Pima Indians and in a separate replication sample of 2,944 predominately non–full-heritage subjects from the same community.

RESULTS
Variants spanning the upstream region of SIM1 through intron 8 were associated with BMI in the full-heritage Pima Indians, where the strongest associations (P ∼ 10−4 to 10−6) were with common variants (risk allele frequency 0.61–0.67). The difference in mean BMI between individuals homozygous for the major allele compared with homozygotes for the minor allele was ∼2.2 kg/m2 (P = 2 × 10−5 for rs3213541). These associations replicated in the separate sample of subjects from the same community (P = 5 × 10−3 for rs3213541). The strongest associations (P = 4 × 10−7, controlled for age, sex, birth year, and heritage) were seen in the combined sample (n = 6,194). The risk allele for obesity was more common in full-heritage Pimas than in the mixed-heritage subjects. Two variants (rs3734353 and rs3213541) were also genotyped in 1,275 severely obese and 1,395 lean control subjects of French European ancestry. The Pima risk alleles were the minor alleles in the European samples, and these variants did not display any significant association (P &gt; 0.05).

CONCLUSIONS
Common variation in SIM1 is associated with BMI on a population level in Pima Indians where the risk allele is the major allele.
Beneficial Endocrine but Adverse Exocrine Effects of Sitagliptin in the Human Islet Amyloid Polypeptide Transgenic Rat Model of Type 2 Diabetes
Authors: Matveyenko Aleksey V. , Dry Sarah , Cox Heather I. , Moshtaghian Artemis , Gurlo Tatyana , Galasso Ryan , Butler Alexandra E. , Butler Peter C. 
Published: April 2009

OBJECTIVE
We sought to establish the extent and mechanisms by which sitagliptin and metformin singly and in combination modify islet disease progression in human islet amyloid polypeptide transgenic (HIP) rats, a model for type 2 diabetes.

RESEARCH DESIGN AND METHODS
HIP rats were treated with sitagliptin, metformin, sitagliptin plus metformin, or no drug as controls for 12 weeks. Fasting blood glucose, insulin sensitivity, and β-cell mass, function, and turnover were measured in each group.

RESULTS
Sitagliptin plus metformin had synergistic effects to preserve β-cell mass in HIP rats. Metformin more than sitagliptin inhibited β-cell apoptosis. Metformin enhanced hepatic insulin sensitivity; sitagliptin enhanced extrahepatic insulin sensitivity with a synergistic effect in combination. β-Cell function was partially preserved by sitagliptin plus metformin. However, sitagliptin treatment was associated with increased pancreatic ductal turnover, ductal metaplasia, and, in one rat, pancreatitis.

CONCLUSIONS
The combination of metformin and sitagliptin had synergistic actions to preserve β-cell mass and function and enhance insulin sensitivity in the HIP rat model of type 2 diabetes. However, adverse actions of sitagliptin treatment on exocrine pancreas raise concerns that require further evaluation.
Glucagon-Like Peptide-1 Protects β-Cells Against Apoptosis by Increasing the Activity of an Igf-2/Igf-1 Receptor Autocrine Loop
Authors: Cornu Marion , Yang Jiang-Yan , Jaccard Evrim , Poussin Carine , Widmann Christian , Thorens Bernard 
Published: April 2009

OBJECTIVE
The gluco-incretin hormones glucagon-like peptide (GLP)-1 and gastric inhibitory peptide (GIP) protect β-cells against cytokine-induced apoptosis. Their action is initiated by binding to specific receptors that activate the cAMP signaling pathway, but the downstream events are not fully elucidated. Here we searched for mechanisms that may underlie this protective effect.

RESEARCH DESIGN AND METHODS
We performed comparative transcriptomic analysis of islets from control and GipR−/−;Glp-1-R−/− mice, which have increased sensitivity to cytokine-induced apoptosis. We found that IGF-1 receptor expression was markedly reduced in the mutant islets. Because the IGF-1 receptor signaling pathway is known for its antiapoptotic effect, we explored the relationship between gluco-incretin action, IGF-1 receptor expression and signaling, and apoptosis.

RESULTS
We found that GLP-1 robustly stimulated IGF-1 receptor expression and Akt phosphorylation and that increased Akt phosphorylation was dependent on IGF-1 but not insulin receptor expression. We demonstrated that GLP-1–induced Akt phosphorylation required active secretion, indicating the presence of an autocrine activation mechanism; we showed that activation of IGF-1 receptor signaling was dependent on the secretion of IGF-2. We demonstrated, both in MIN6 cell line and primary β-cells, that reducing IGF-1 receptor or IGF-2 expression or neutralizing secreted IGF-2 suppressed GLP-1–induced protection against apoptosis.

CONCLUSIONS
An IGF-2/IGF-1 receptor autocrine loop operates in β-cells. GLP-1 increases its activity by augmenting IGF-1 receptor expression and by stimulating secretion; this mechanism is required for GLP-1–induced protection against apoptosis. These findings may lead to novel ways of preventing β-cell loss in the pathogenesis of diabetes.
Influence of Fat and Carbohydrate Proportions on the Metabolic Profile in Patients With Type 2 Diabetes: A Meta-Analysis
Authors: Kodama Satoru , Saito Kazumi , Tanaka Shiro , Maki Miho , Yachi Yoko , Sato Mutsumi , Sugawara Ayumi , Totsuka Kumiko , Shimano Hitoshi , Ohashi Yasuo , Yamada Nobuhiro , Sone Hirohito 
Published: April 2009

OBJECTIVE
The effects of dietary macronutrient composition on metabolic profiles in patients with type 2 diabetes have been inconsistent. This meta-analysis aimed to elucidate the effect of replacing dietary fat with carbohydrate on glucose and lipid parameters in patients with type 2 diabetes.

RESEARCH DESIGN AND METHODS
We searched for randomized trials that investigated the effects of two kinds of prescribed diets (a low-fat, high-carbohydrate [LFHC] diet and a high-fat, low-carbohydrate [HFLC] diet); in these studies, energy and protein intake did not differ significantly between the two dietary groups. Nineteen studies that included 306 patients met our inclusion criteria. Median diet composition of carbohydrate/fat in the LFHC and HFLC diets was 58%/24% and 40%/40%, respectively.

RESULTS
Changes in values for A1C, fasting plasma glucose (FPG), and total and LDL cholesterol did not differ significantly between the LFHC and HFLC groups. However, the LFHC diet significantly increased fasting insulin and triglycerides by 8% (P = 0.02) and 13% (P &lt; 0.001), respectively, and lowered HDL cholesterol by 6% (P &lt; 0.001) compared with the HFLC diet. There were positive associations among the magnitude of changes in FPG, fasting insulin, and triglycerides for the diets analyzed. However, stratified analysis indicated that the increase in triglycerides was insignificant when accompanied by energy intake restriction.

CONCLUSIONS
Our findings suggested that replacing fat with carbohydrate could deteriorate insulin resistance while the adverse effect on triglycerides from the LFHC diet could be avoided by restricting energy intake to a degree sufficient for the attainment of weight reduction.
Crib‐biting in US horses: Breed predispositions and owner perceptions of aetiology
Authors: ALBRIGHT J. D. , MOHAMMED H. O. , HELESKI C. R. , WICKENS C. L. , HOUPT K. A. 
Published: April 2009

Summary Reasons for performing study: Crib‐biting is an equine stereotypy that may result in diseases such as colic. Certain breeds and management factors have been associated. Objectives: To determine: breed prevalence of crib‐biting in US horses; the likelihood that one horse learns to crib‐bite from another; and owner perceptions of causal factors. Methods: An initial postal survey queried the number and breed of crib‐biting horses and if a horse began after being exposed to a horse with this habit. In a follow‐up survey, a volunteer subset of owners was asked the number of affected and nonaffected horses of each breed and the extent of conspecific contact. The likelihood of crib‐biting given breed and extent of contact was quantified using odds ratio (OR) and significance of the association was assessed using the Chi‐squared test. Results: Overall prevalence was 4.4%. Thoroughbreds were the breed most affected (13.3%). Approximately half of owners believed environmental factors predominantly cause the condition (54.4%) and crib‐biting is learned by observation (48.8%). However, only 1.0% of horses became affected after being exposed to a crib‐biter. The majority (86%) of horses was turned out in the same pasture with other horses and extent of contact with conspecifics was not statistically related to risk. Conclusion: This is the first study to report breed prevalence for crib‐biting in US horses. Thoroughbreds were the breed more likely to be affected. More owners believed either environmental conditions were a predominant cause or a combination of genetic and environmental factors contributes to the behaviour. Only a small number of horses reportedly began to crib‐bite after being exposed to an affected individual, but approximately half of owners considered it to be a learned behaviour; most owners did not isolate affected horses. Potential relevance: Genetic predisposition, not just intensive management conditions and surroundings, may be a factor in the high crib‐biting prevalence in some breeds, and warrants further investigation. Little evidence exists to suggest horses learn the behaviour from other horses, and isolation may cause unnecessary stress.
The effect of training on stride parameters in a cohort of National Hunt racing Thoroughbreds: A preliminary study
Authors: FERRARI M. , PFAU T. , WILSON A. M. , WELLER R. 
Published: April 2009

Summary Reasons for performing study: The influence of training on stride parameters is controversial and to date there is no information on how training influences stride parameters during high‐speed locomotion in the field. Objective: To determine the influence of training on stride variables during high‐speed locomotion in Thoroughbred racehorses. Methods: Speed, stride frequency, stance and protraction times were quantified in 8 Thoroughbreds with foot mounted accelerometers and GPS sensors during their first week of canter after the summer break and 6 months into training. Results: At a speed of 11 m/s, stride frequency was (mean ± s.d.) 2.160 ± 0.120 strides/s pre‐ and 2.167 ± 0.083 strides/s post training; mean stance time was 125.3 ± 9 ms pre‐ and 125.9 ± 7 ms post training; protraction time was 340.7 ± 20.4 ms pre‐ and 337.2 ± 14.3 ms post training. The increase in stride frequency and the decrease in protraction time after training were significant. There was no statistically significant difference in the maximum speed reached by each horse pre‐ and post training. Conclusions: Stance time stayed constant throughout the training season in the tested horses. A significant decrease in protraction time and a corresponding significant increase in stride frequency were observed after training. Potential relevance: Training of racehorses could be adapted to maximise the effect on modifiable parameters and reduce the risk of training‐induced pathologies. Further research will be conducted to investigate the effect of different training protocols on a large number of horses.
Modeling the Temperature Development of Wall-slipping Polymers in Single-screw Channels
Authors: Kurte-Jardin M. , Potente H. , Sigge K. , Bornemann M. 
Published: April 2009

Abstract
Wall-slipping materials show lower melt temperature increase than wall-adhering materials on account of the reduced dissipated power component in the system, as is set out in Potente and Kurte-Jardin (2005) and Potente et al. (2005a). Up until now, however, there have not been any models for describing the development of the melt temperature in a single-screw channel when wall-slipping polymers are being processed. For this reason, a methodology of predicting the melt temperature is described. The new model is based on an existing analytical procedure that has been extended by numerical flow simulation results of isothermal 2,5D FE calculations. A comparison of the predicted mean melt temperatures with non-isothermal 3D FE flow simulation results leads to good agreement, what justifies further investigations.
A Novel Dilatometer for PVT Measurements of Polymers at High Cooling – and Shear Rates
Authors: Forstner R. , Peters G. W. M. , Meijer H. E. H. 
Published: April 2009

Abstract
A novel dilatometer to investigate the specific volume of polymers as a function of the combined effect of pressure (100 MPa), temperature (300°C), cooling rate (100°C/s) and shear rate (200 l/s) was developed. The dilatometer consists of a pressure cell, which in design is a combination of a traditional “piston-die type” dilatometer and a Couette rheometer, embedded in a custom made frame, which allowed for scaling down to a “table-sized” machine that requires only standard laboratory supplies, like pressurized air and tap water, for operation and cooling. We implemented software for fully automated control of procedures to operate non-isothermal experiments with shear steps applied at predefined temperatures. The sample rings (m ≈ 65 mg) used in the dilatometer are made with a micro injection moulding machine. Experiments with two commercial isotactic Polypropylene (iPP) grades at low cooling rates, performed by two independent groups, were compared with measurements from a commercial confined fluids dilatometer showing small relative differences in the range of 0.03 to 0.3%. As an example, additional results of an isotactic polypropylene were chosen to show the profound influence of cooling rate and melt shearing on the evolution of specific volume.
A Direct 3D Numerical Simulation Code for Extrusion and Mixing Processes
Authors: Valette R. , Coupez T. , David C. , Vergnes B. 
Published: April 2009

Abstract
This work focuses on the development of a general finite element code devoted to the three-dimensional direct simulation of mixing processes of complex fluids. The code, developed from the CimLib© Library, is based on a domain immersion method coupled with a “level-set” approach to represent the rigid moving boundaries, such as screws and rotors, as well as free surfaces. These techniques, combined with the use of automatized parallel computing, allow calculating the time-dependent flow of generalized Newtonian fluids in large and complex processes, involving moving free surfaces which are treated by a level-set/Hamilton-Jacobi method. Three examples of flow case studies are presented in this paper: the flow within the mixing section of a twinscrew extruder, the flow in an internal mixer and the flow in a batch mixer.
The Effect of Bead Vacuum on Slot Die Coating
Authors: Chang H.-M. , Lee C.-C. , Liu T.-J. 
Published: April 2009

Abstract
The effect of bead vacuum on the minimum wet thickness obtained on horizontal and vertical slot die coatings was experimentally examined using a flow visualization technique. The commercial software package FLOW3D was used to simulate the two-dimensional coating flow. Macroscopic material balances were applied to estimate the effect of bead vacuum. Applying vacuum on the coating bead was found to reduce the minimum wet thickness and increase the maximum coating speed, with the effect on horizontal slot die coating being more pronounced. Visual observations revealed that with increasing vacuum, the upstream meniscus against the moving web was pulled back significantly for a low-viscosity solution, and the dynamic contact angle was reduced for a high-viscosity solution. The observed upstream wetting length for a low-viscosity solution subject to bead vacuum was consistent with the prediction using macroscopic balances. The sizes of coating beads predicted by FLOW3D were generally larger than those observed from flow visualization. Coating failures caused by high bead vacuum could be predicted with the aid of numerical simulations.
Numerical Simulation of a Thermoviscoelastic Frictional Problem with Application to the Hot-Embossing Process for Manufacturing of Microcomponents
Authors: Kabanemi K. K. , Marcotte J. P. , Hétu J. F. , Worgull M. , Heckele M. 
Published: April 2009

Abstract
Hot embossing is a compression molding technique used for high replication accuracy of small features. One of the most sensitive phases of the process is the de-embossing stage during which the patterned part has to be demolded. In this paper, the demolding stage is considered as a frictional contact problem between a rigid mold insert and a viscoelastic polymer sheet as it deforms and cools inside a mold under an applied force. The contact is modeled with a modified Coulomb's law of dry friction while a generalized Maxwell model is used to describe the polymer behavior during embossing, cooling and de-embossing stages. The heat transfer between the mold insert and the patterned polymer sheet is solved through a domain decomposition method. A finite element approximation based on a penalized technique is proposed and analyzed. The purpose of this modeling approach is to predict dimensional stability and residual shape of microcomponents in the hot embossing process. Such a prediction will allow one to assign appropriate processing conditions that minimize geometrical imperfections and increase replication accuracy.
Modeling of Melt Conveying in a Novel Screw-Nested Extruder
Authors: Jia M.-Y. , Yu J. , Xue P. , Guo Z.-X. 
Published: April 2009

Abstract
A novel screw-nested extruder is fabricated, which consists of double extrusion systems. The inner screw couples with one inner barrel, whose outer configuration acts as the screw for the outer barrel. The nested screw extrusion systems can co-extrude when the inner barrel/outer screw rotates. Each extrusion system can also work independently as one general extruder. A new mathematical model of an isothermal Newtonian flow is developed to describe the melt flow in the extruder. The analytical solutions of flow rate are well in agreement with the Campbell's experimental data for screw drag flow, screw flight displacement flow and barrel drag flow when the boundary conditions are obtained for the special cases in which the screw core, screw flight and the barrel rotate independently or in pairs. This can not be explained by conventional parallel-plate models. Further, the model is also well used to analyze the melt flow in the inner extrusion system of the novel nested screw extruder.
Rheological and Thermal Properties of a Model System for PIM
Authors: Persson H. , Hausnerová B. , Nyborg L. , Rigdahl M. 
Published: April 2009

Abstract
Powder injection moulding (PIM) is an important and accepted industrial technique for net shaping of precision components which can have a rather complex geometry. In order to meet the imposed, often rather strict, requirements with regard to dimensional accuracy, it is important to have an adequate knowledge and control of the rheological behaviour and the related processing properties of the powder/polymer melt (feedstock). Such a knowledge is furthermore of crucial importance in numerical simulations of the PIM-process. In the present work, a model system, consisting of steel powder, poly(ethylene glycol) and wax, is used in order to illustrate how the viscometric properties as well as thermal properties, such as the conductivity and the specific heat, of the system can be related to the corresponding properties of the polymeric binder system. In a similar way, the pvT (pressure-volume-temperature)-behaviour of the model system is analysed and discussed. The pvT-behaviour, which has not been extensively reported on for PIM-feedstocks, is considered to be of significant relevance for controlling the outcome of the injection moulding process.
Antidiabetic and Hypolipidemic Effects of Different Fractions of Catharanthus Roseus (Linn.) on Normal and Streptozotocin-induced Diabetic Rats
Authors: Islam M. A. , Akhtar M. A. , Islam M. R. , Hossain M. S. , Alam M. K. , Wahed M. I. I. , Rahman B. M. , Anisuzzaman A. S. M. , Shaheen S. M. , Ahmed Maruf 
Published: April 2009

The antidiabetic and hypolipidemic effects of petroleum-ether, ethyl acetate and chloroform fractions from ethanolic extract of the leaves of Catharanthus roseus (C. roseus) were investigated in normal and streptozotocin-induced diabetic rats (SIDRs). Single doses (150 mg/kg, i.p.) of C. roseus extracts in the fasting blood glucose (FBG) levels were determined in normal and SIDRs on 0, 1, 2, 3, 6, 10, 16, and 24th hours and serum triglyceride (TG) and serum total cholesterol (TC) levels were determined after 24th hour. In normoglycemic rats and in SIDRs, petroleum-ether and ethyl acetate fraction of C. roseus reduced blood glucose level significantly. In case of hypolipidemic effects, all fractions reduced serum total cholesterol but the ethyl acetate fraction of C. roseus was the most effective. All fractions of C. roseus reduced serum triglyceride level but the ethyl acetate fraction reduced triglyceride level at the highest. The antidiabetic and hypolipidemic activities were compared to metformin HCl (150 mg/kg). Of all the three fractions, ethyl acetate fractions were the best in activity. Ethyl acetate fraction of C. roseus was found to contain flavonoids and alkaloids. The mechanism underlying the antidiabetic activity is probably increased glycogenesis, decreased gluconeogenesis or decreased absorption of glucose from intestine. Keywords: Catharanthus roseus; Antidiabetic; Hypolipidemic; Streptozotocin-induced diabetic rat.© 2009 JSR Publications. ISSN: 2070-0237 (Print); 2070-0245 (Online). All rights reserved.DOI: 10.3329/jsr.v1i2.1075
Computation of Axisymmetric Turbulent Viscous Flow Around Sphere
Authors: Karim M. M. , Rahman M. M. , Alim M. A. 
Published: April 2009

Axisymmetric turbulent viscous flow around sphere is computed using finite volume method based on Reynolds-averaged Navier-Stokes (RANS) equations.Â Two-dimensional axisymmetric flow solver has been used to analyze flow at Reynolds number of 5Ã106. Spalart-Allmaras (S-A) and shear stress transport (SST) k-Ï turbulence models are used to capture turbulent viscous flow. The numerical results in terms of the skin friction coefficient, pressure coefficient and drag coefficient for different Reynolds numbers have been shown either graphically or in the tabular form. Velocity vectors have been displayed graphically. The computed results show good agreement with published experimental measurements. Keywords: Axisymmetric body of revolution; Sphere; Viscous drag; CFD; Turbulence model; Reynolds-averaged Navier-Stokes (RANS) equations. © 2009 JSR Publications. ISSN: 2070-0237 (Print); 2070-0245 (Online). All rights reserved. DOI: 10.3329/jsr.v1i2.1286