bluuebunny/crossref_metadata_2025_split huggingface dataset:
ChemInform Abstract: Electrochemical versus Heat‐Engine Energy Technology: A Tribute to Wilhelm Ostwald′s Visionary Statements
Authors: Kunze Julia , Stimming Ulrich 
Published: January 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Recent Advances in Molecular Magnetic Materials
Authors: Murray Keith S. 
Published: January 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: The Bioconjugation of Redox Proteins to Novel Electrode Materials
Authors: Goldstein Daniel C. , Thordarson Pall , Peterson Joshua R. 
Published: January 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Electrides: Early Examples of Quantum Confinement
Authors: Dye James L. 
Published: January 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Two‐Dimensional Vibrational Spectroscopy of Rotaxane‐Based Molecular Machines
Authors: Bodis Pavol , Panman Matthijs R. , Bakker Bert H. , Mateo‐Alonso Aurelio , Prato Maurizio , Buma Wybren Jan , Brouwer Albert M. , Kay Euan R. , Leigh David A. , Woutersen Sander 
Published: January 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Censored time series analysis with autoregressive moving average models
Authors: Park Jung Wook , Genton Marc G. , Ghosh Sujit K. 
Published: January 2010

AbstractThe authors consider time series observations with data irregularities such as censoring due to a detection limit. Practitioners commonly disregard censored data cases which often result in biased estimates. The authors present an attractive remedy for handling autocorrelated censored data based on a class of autoregressive and moving average (ARMA) models. In particular, they introduce an imputation method well suited for fitting ARMA models in the presence of censored data. They demonstrate the effectiveness of their technique in terms of bias, efficiency, and information loss. They also describe its adaptation to a specific context of meteorological time series data on cloud ceiling height, which are measured subject to the detection limit of the recording device.
Consistent testing for non‐correlation of two cointegrated ARMA time series
Authors: Saidi Abdessamad 
Published: January 2010

AbstractA consistent approach to the problem of testing non‐correlation between two univariate infinite‐order autoregressive models was proposed by Hong (1996). His test is based on a weighted sum of squares of residual cross‐correlations, with weights depending on a kernel function. In this paper, the author follows Hong's approach to test non‐correlation of two cointegrated (or partially non‐stationary) ARMA time series. The test of Pham, Roy & Cédras (2003) may be seen as a special case of his approach, as it corresponds to the choice of a truncated uniform kernel. The proposed procedure remains valid for testing non‐correlation between two stationary invertible multivariate ARMA time series. The author derives the asymptotic distribution of his test statistics under the null hypothesis and proves that his procedures are consistent. He also studies the level and power of his proposed tests in finite samples through simulation. Finally, he presents an illustration based on real data.
A bayesian estimator for the dependence function of a bivariate extreme‐value distribution
Authors: Guillotte Simon , Perron François 
Published: January 2010

AbstractAny continuous bivariate distribution can be expressed in terms of its margins and a unique copula. In the case of extreme‐value distributions, the copula is characterized by a dependence function while each margin depends on three parameters. The authors propose a Bayesian approach for the simultaneous estimation of the dependence function and the parameters defining the margins. They describe a nonparametric model for the dependence function and a reversible jump Markov chain Monte Carlo algorithm for the computation of the Bayesian estimator. They show through simulations that their estimator has a smaller mean integrated squared error than classical nonparametric estimators, especially in small samples. They illustrate their approach on a hydrological data set.
On population‐based measures of agreement for binary classifications
Authors: Nelson Kerrie P. , Edwards Don 
Published: January 2010

AbstractThe authors describe a model‐based kappa statistic for binary classifications which is interpretable in the same manner as Scott's pi and Cohen's kappa, yet does not suffer from the same flaws. They compare this statistic with the data‐driven and population‐based forms of Scott's pi in a population‐based setting where many raters and subjects are involved, and inference regarding the underlying diagnostic procedure is of interest. The authors show that Cohen's kappa and Scott's pi seriously underestimate agreement between experts classifying subjects for a rare disease; in contrast, the new statistic is robust to changes in prevalence. The performance of the three statistics is illustrated with simulations and prostate cancer data.
Bias reduction for nonparametric correlation coefficients under the bivariate normal copula assumption with known detection limits
Authors: Nie Lei , Chu Haitao , Korostyshevskiy Valeriy R. 
Published: January 2010

AbstractThe authors derive the asymptotic mean and bias of Kendall's tau and Spearman's rho in the presence of left censoring in the bivariate Gaussian copula model. They show that tie corrections for left‐censoring brings the value of these coefficients closer to zero. They also present a bias reduction method and illustrate it through two applications.
Nonparametric adaptive likelihood weights
Authors: Plante Jean‐François 
Published: January 2010

AbstractThe weighted likelihood can be used to make inference about one population when data from similar populations are available. The author shows heuristically that the weighted likelihood can be seen as a special case of the entropy maximization principle. This leads him to propose the minimum averaged mean squared error (MAMSE) weights. He describes an algorithm for calculating these weights and shows its convergence using the Kuhn‐Tucker conditions. He explores the performance and properties of the weighted likelihood based on MAMSE weights through simulations.
Inference in the presence of ranking error in ranked set sampling
Authors: Ozturk Omer 
Published: January 2010

AbstractThe author proposes inference techniques for ranked set sample data in the presence of judgment ranking errors. He bases his analysis on the models of Bohn & Wolfe (1994) and Frey (2007a, b), of which parameters are estimated by minimizing a distance measure. He then uses the fitted models to calibrate confidence intervals and tests. He shows the validity of his approach through simulation and illustrates its application through the construction of distribution‐free confidence intervals for the median area of apple tree leaves covered by a spray.
Dissecting racial disparities in the treatment of patients with locoregional pancreatic cancer
Authors: Riall Taylor S. , Townsend Courtney M. , Kuo Yong‐Fang , Freeman Jean L. , Goodwin James S. 
Published: January 2010

AbstractBACKGROUND:Previous studies have demonstrated that black patients with pancreatic cancer are less likely to undergo resection and have worse overall survival compared with white patients. The objective of this study was to determine whether these disparities occur at the point of surgical evaluation or after evaluation has taken place.METHODS:The authors used the Surveillance, Epidemiology, and End Results (SEER)‐Medicare linked data (1992‐2002) to compare black patients and white patients with locoregional pancreatic cancer in univariate models. Logistic regression was used to determine the effect of race on surgical evaluation and on surgical resection after evaluation. Cox proportional hazards models were used to identify which factors influenced 2‐year survival.RESULTS:Nine percent of 3777 patients were black. Blacks were substantially less likely than whites to undergo evaluation by a surgeon (odds ratio, 0.57; 95% confidence interval, 0.42‐0.77) when the model was adjusted for demographics, tumor characteristics, surgical evaluation, socioeconomic status, and year of diagnosis. Patients who were younger and who had fewer comorbidities, abdominal imaging, and a primary care physician were more likely to undergo surgical evaluation. Once they were seen by a surgeon, blacks still were less likely than whites to undergo resection (odds ratio, 0.64; 95% confidence interval, 0.49‐0.84). Although black patients had decreased survival in an unadjusted model, race no longer was significant after accounting for resection.CONCLUSIONS:Twenty‐nine percent of black patients with potentially resectable pancreatic cancers never received surgical evaluation. Without surgical evaluation, patients cannot make an informed decision and will not be offered resection. Attaining higher rates of surgical evaluation in black patients would be the first step to eliminating the observed disparity in the resection rate. Cancer 2010. © 2010 American Cancer Society
Epstein‐Barr virus latent membrane protein 1 mRNA is expressed in a significant proportion of patients with chronic lymphocytic leukemia
Authors: Tarrand Jeffrey J. , Keating Michael J. , Tsimberidou Apostolia M. , O'Brien Susan , LaSala Rocco P. , Han Xiang‐Yang , Bueso‐Ramos Carlos E. 
Published: January 2010

AbstractBACKGROUND:Epstein‐Barr virus (EBV) infection has been associated with Richter transformation in patients with chronic lymphocytic leukemia (CLL).METHODS:A direct isothermal mRNA amplification method was developed for detection of EBV latent membrane protein 1 (LMP1) mRNA transcriptional activity in the peripheral blood of 135 chronic lymphocytic leukemia patients and 98 hematologically healthy control subjects.RESULTS:EBV LMP1 mRNA transcripts were found in 19 of 135 (14%) of the CLL cases, but only 1% of the healthy controls (P < .0001). In contrast, 23 solid tumor patients tested negative for EBV LMP1 transcripts. In a later cohort of patients after hematopoietic stem cell transplantation, 4 of 7 patients with Hodgkin lymphoma or Burkitt lymphoma had EBV LMP1 detected. In a preliminary analysis, outcome data were available for 88 of the 135 patients with CLL. EBV LMP1 mRNA positivity was associated with a significantly increased degree of histologically demonstrated bone marrow involvement by CLL (P = .003, Mann‐Whitney U test).CONCLUSIONS:EBV LMP1 mRNA transcriptional activity was observed in a significant proportion of CLL patients. Transcription of the EBV LMP1, a late gene with known transforming potential in vitro, suggests that EBV activation plays a role in CLL disease progression. Thus, EBV LMP1 expression in CLL patients may be a factor involved in the genesis of refractory disease. Cancer 2010. © 2010 American Cancer Society.
p53 and MDM2 in renal cell carcinoma
Authors: Noon Aidan P. , Vlatković Nikolina , Polański Radosław , Maguire Maria , Shawki Howida , Parsons Keith , Boyd Mark T. 
Published: January 2010

AbstractRenal cell carcinoma (RCC) is the most common type of kidney cancer and follows an unpredictable disease course. To improve prognostication, a better understanding of critical genes associated with disease progression is required. The objective of this review was to focus attention on 2 such genes, p53 and murine double minute 2 (MDM2), and to provide a comprehensive summary and critical analysis of the literature regarding these genes in RCC. Information was compiled by searching the PubMed database for articles that were published or e‐published up to April 1, 2009. Search terms included renal cancer, renal cell carcinoma, p53, and MDM2. Full articles and any supplementary data were examined; and, when appropriate, references were checked for additional material. All studies that described assessment of p53 and/or MDM2 in renal cancer were included. The authors concluded that increased p53 expression, but not p53 mutation, is associated with reduced overall survival/more rapid disease progression in RCC. There also was evidence that MDM2 up‐regulation is associated with decreased disease‐specific survival. Two features of RCC stood out as unusual and will require further investigation. First, increased p53 expression is tightly linked with increased MDM2 expression; and, second, patients who have tumors that display increased p53 and MDM2 expression may have the poorest overall survival. Because there was no evidence to support the conclusion that p53 mutation is associated with poorer survival, it seemed clear that increased p53 expression in RCC occurs independent of mutation. Further investigation of the mechanisms leading to increased p53/MDM2 expression in RCC may lead to improved prognostication and to the identification of novel therapeutic interventions. Cancer 2010. © 2010 American Cancer Society.
Nonsynonymous single nucleotide polymorphisms in DNA damage repair pathways and lung cancer risk
Authors: Tanaka Yugo , Maniwa Yoshimasa , Bermudez Vladimir P. , Doi Takefumi , Nishio Wataru , Ohbayashi Chiho , Okita Yutaka , Hurwitz Jerard , Hayashi Yoshitake , Yoshimura Masahiro 
Published: January 2010

AbstractBACKGROUND:Several reports have revealed the association between single nucleotide polymorphisms (SNPs) and the development of cancer. Although many SNPs have been investigated, they were tested individually. In this study, nonsynonymous SNPs present in DNA damage response genes were comprehensively analyzed for lung cancer susceptibility.METHODS:The authors selected 37 nonsynonymous SNPs in 23 genes involved in DNA damage repair pathways. Fifty lung adenocarcinoma patients resected at their institution between 2002 and 2005 and 50 individuals without any known history of cancer were recruited for a case‐control study.RESULTS:Three variants (XRCC1 194Trp homozygotes, POLδ1 119His homozygotes, and RAD9 239Arg heterozygotes) tended to coassociate with lung cancer risk. The authors analyzed and calculated whether the association between combinations of these 3 SNPs significantly affected the risk of lung cancer. Compared with carriers of either XRCC1 194Trp homozygote or RAD9 239Arg heterozygote variants, noncarriers were at a significantly decreased risk for lung cancer (odds ratio [OR], 0.282; confidence interval [CI], 0.089‐0.893). The same results were found for the combination of POLδ1 119His homozygotes and RAD9 239Arg heterozygotes (OR, 0.277; CI, 0.077‐0.993). Moreover, compared with carriers that had at least 1 of the 3 variants, noncarriers showed a more significant decrease in risk (OR, 0.263; CI, 0.090‐0.767).CONCLUSIONS:Analysis of the presence of XRCC1 194Trp homozygote, POLδ1 119His homozygote, and RAD9 239Arg heterozygote variants revealed that their coassociation leads to a significant risk for the development of lung adenocarcinoma. Inclusive analyses of different SNPs were important in this cancer risk study. Cancer 2010. © 2010 American Cancer Society.
N1S3: A revised staging system for head and neck cutaneous squamous cell carcinoma with lymph node metastases
Authors: Forest Veronique‐Isabelle , Clark Jonathan J. , Veness Michael J. , Milross Chris 
Published: January 2010

AbstractBACKGROUND.A staging system was designed for metastatic cutaneous squamous cell carcinoma (SCC) that would incorporate the parotid as a regional level and facilitate a better prognostic discrimination between subgroups.METHODS.A retrospective review of clinical and pathological information of patients treated for metastatic cutaneous SCC to the parotid and/or neck was conducted. Potential prognostic factors were analyzed using univariate and multivariate analyses. A staging system was elaborated and externally validated.RESULTS.Two hundred fifteen patients were included. All patients had surgery as their primary treatment; 148 had parotidectomy with neck dissection, 50 parotidectomy alone, and 18 neck dissection alone. One hundred seventy‐five patients received postoperative radiotherapy. On univariate analysis, the number of involved lymph nodes (P < .001), maximal size (P = .01), and extracapsular spread (P = .003) were found to be significant predictors of survival. On Cox regression, the number of involved lymph nodes as single or multiple (P = .006) was significant. The N1S3 staging system incorporates involved lymph nodes from parotid and neck (single or multiple) and the size (< or >3 cm). This system demonstrates significant predictive capacity for locoregional control (P < .001), disease‐specific survival (P<.0001), and overall survival (P<.0001). N1S3 was tested on a different cohort of 250 patients, and the results confirmed those obtained from our primary analyses.CONCLUSIONS.The N1S3 system stages patients according to the number of involved lymph nodes and size, and incorporates parotid as 1 of the regional levels. These 2 predictors are easily applied on both clinical and pathological data. Cancer 2010. © 2010 American Cancer Society.
Impact of smoking on patients with stage III colon cancer
Authors: McCleary Nadine Jackson , Niedzwiecki Donna , Hollis Donna , Saltz Leonard B. , Schaefer Paul , Whittom Renaud , Hantel Alexander , Benson Al , Goldberg Richard , Meyerhardt Jeffrey A. 
Published: January 2010

AbstractBACKGROUND:Cigarette smoking has been shown to increase the risk of developing colorectal cancer, particularly smoking early in life. Little is known about the impact of tobacco use on colon cancer recurrence among colon cancer survivors.METHODS:The authors prospectively collected lifetime smoking history from stage III colon cancer patients enrolled in a phase 3 trial via self‐report questionnaires during and 6 months after completion of adjuvant chemotherapy. Smoking status was defined as never, current, or past. Lifetime pack‐years were defined as number of lifetime packs of cigarettes. Patients were followed for recurrence or death.RESULTS:Data on smoking history were captured on 1045 patients with stage III colon cancer receiving adjuvant therapy (46% never smokers; 44% past; 10% current). The adjusted hazard ratio (HR) for disease‐free survival (DFS) was 0.99 (95% confidence interval [CI], 0.70‐1.41), 1.17 (95% CI 0.89‐1.55), and 1.22 (95% CI 0.92‐1.61) for lifetime pack‐years 0‐10, 10‐20, and 20+, respectively, compared with never smoking (P = .16). In a preplanned exploratory analysis of smoking intensity early in life, the adjusted HR for 12+ pack‐years before age 30 years for DFS was 1.37 (95% CI, 1.02‐1.84) compared with never smoking (P = .04). The adjusted HR for DFS was 1.18 (95% CI, 0.92‐1.50) for past smokers and 1.10 (95% CI, 0.73‐1.64) for current smokers, compared with never smokers.CONCLUSIONS:Total tobacco usage early in life may be an important, independent prognostic factor of cancer recurrences and mortality in patients with stage III colon cancer. Cancer 2010. © 2010 American Cancer Society.
A randomized phase 2 trial comparing 3‐hour versus 96‐hour infusion schedules of paclitaxel for the treatment of metastatic breast cancer
Authors: Moulder Stacy L. , Holmes Frankie A. , Tolcher Anthony W. , Thall Peter , Broglio Kristine , Valero Vicente , Buzdar Aman U. , Arbuck Susan G. , Seidman Andrew , Hortobagyi Gabriel N. 
Published: January 2010

AbstractBACKGROUND:This study was performed to compare efficacy and toxicity profiles of paclitaxel using 3‐hour versus 96‐hour infusion schedules.METHODS:Patients with metastatic breast cancer (MBC) were randomly assigned to receive paclitaxel starting at a dose of 250 mg/m2intravenously (iv) over 3 hours every 21 days or paclitaxel starting at a dose of 140 mg/m2iv over 96 hours every 21 days. Stratification variables included number of prior chemotherapy regimens and previous response to anthracyclines. Response was assessed every 2 cycles using bidimensional measurements. Patients were allowed to cross over at disease progression or therapy intolerance.RESULTS:A total of 214 patients received therapy (107 patients per arm). Response rates were similar: 23.4% in the 3‐hour arm and 29.9% in the 96‐hour arm (P= .28). The median duration of response (8.9 months vs 5.7 months;P= .75) and progression‐free survival (5.0 months vs 3.8 months;P= .17) slightly favored the 96‐hour arm. Overall survival was slightly longer in the 3‐hour arm (14.2 months vs 12.7 months;P= .57). One patient who crossed over to the 96‐hour arm (N = 18) developed a partial response; no response was noted with crossover to the 3‐hour arm (N = 10). Myalgia/arthralgia and neuropathy were more frequent in the 3‐hour arm, whereas mucositis, neutropenic fever/infection, and diarrhea were more common in the 96‐hour arm.CONCLUSIONS:Paclitaxel given by 3‐hour or 96‐hour infusion was active in MBC. The 96‐hour paclitaxel regimen did not significantly improve response or time to disease progression, was more cumbersome to administer, and was associated with greater myelosuppression (but less neuropathy and myalgia) compared with the 3‐hour schedule. Cancer 2010. © 2010 American Cancer Society.
An Electrochemical and Photophysical Study of a Covalently Linked Inorganic–Organic Dyad
Authors: Kahnt Axel , Heiniger Leo‐Philipp , Liu Shi‐Xia , Tu Xiaoyan , Zheng Zhiping , Hauser Andreas , Decurtins Silvio , Guldi Dirk M. 
Published: January 2010

AbstractA molecular donor–acceptor dyad comprising a hexarhenium cluster core, [Re6(μ3‐Se)8]2+, and a fullerene moiety which are covalently linked through a pyridine ligand was synthesized and fully characterized. The electrochemical and photophysical properties are reported. The detailed study includes cyclic voltammetry, steady‐state absorption and fluorescence spectroscopy, radiation chemistry and transient absorption spectroscopy. A light‐induced electron transfer between the inorganic cluster moiety and the fullerene can be excluded. However, a light‐induced energy transfer from the rhenium cluster to the fullerene is proposed.