bluuebunny/crossref_metadata_2025_split huggingface dataset:
Experimental arthritis exacerbates Aggregatibacter actinomycetemcomitans‐induced periodontitis in mice
Authors: Queiroz‐Junior Celso Martins , Madeira Mila Fernandes Moreira , Coelho Fernanda Matos , de Oliveira Camila Ribeiro , Cândido Luíza Castro Menezes , Garlet Gustavo Pompermaier , Teixeira Mauro Martins , de Souza Daniele da Glória , Silva Tarcília Aparecida da 
Published: April 2012

AbstractAimThis study aimed to investigate whether chronic antigen‐induced arthritis (AIA) influences infection‐induced periodontitis (PD) in mice and whether PD modifies the clinical course of AIA. The contribution of anti‐TNF‐α therapy was also evaluated.Materials and methodsThe PD was induced in C57BL/6 mice by oral infection with Aggregatibacter actinomycetemcomitans. AIA was induced after infection. Anti‐TNF‐α and chlorhexidine therapies were used to investigate the role of TNF‐α and oral infection on PD and AIA interaction. Maxillae, knee joints, lymph nodes and serum samples were used for histomorphometric, immunoenzymatic and/or real time‐PCR analyses.ResultsAntigen‐induced arthritis exacerbated alveolar bone loss triggered by PD infection. In contrast, PD did not influence AIA in the evaluated time‐points. PD exacerbation was associated with enhanced production of IFN‐γ in maxillae and expression of the Th1 transcription factor tBET in submandibular lymph nodes. Increased serum levels of IL‐6 and C‐reactive protein were also detected. Anti‐TNF‐α and antiseptic therapies prevented the development and exacerbation of infectious‐PD. Anti‐TNF‐α therapy also resulted in reduced expression of IFN‐γ, TNF‐α and IL‐17 in maxillae.ConclusionsAltogether, the current results indicate that the exacerbation of infection‐induced PD by arthritis is associated with an alteration in lymphocyte polarization pattern and increased systemic immunoreactivity. This process was ameliorated by anti‐TNF‐α and antiseptic therapies.
Comparison of GOHAI and OHIP‐14 measures in relation to objective values of oral function in elderly Japanese
Authors: Ikebe Kazunori , Hazeyama Tomohiro , Enoki Kaori , Murai Shunsuke , Okada Tadashi , Kagawa Ryosuke , Matsuda Ken‐ichi , Maeda Yoshinobu 
Published: April 2012

AbstractObjectivesThe aims of this study were to assess the correlations between the Geriatric Oral Health Assessment Index (GOHAI) and the Oral Health Impact Profile‐14 (OHIP‐14) and to examine which survey is more sensitive to objectively measured oral function in the Japanese elderly.MethodsThe subjects were 290 community‐dwelling, cognitively healthy, and independently living people over the age of 60 years (mean: 66.3 years). Measures included the GOHAI and OHIP‐14 questionnaires, as well as self‐rating of general and oral health, dry mouth, number of residual teeth, and objective values of occlusal force, masticatory performance, and salivary flow rate. Bivariate and linear regression analyses were used to identify which of these variables predicted GOHAI and OHIP‐14 scores.ResultsSpearman's correlation coefficient between the GOHAI and OHIP‐14 scores was 0.728 (P < 0.001), although the OHIP‐14 showed a greater number of 0 scores, suggesting a greater floor effect. At the bivariate level, self‐rating of general and oral health, dry mouth, number of residual teeth, occlusal force, and masticatory performance were associated with GOHAI and OHIP‐14 scores. Multiple linear regression analyses showed that after controlling for the other significant variables, both the occlusal force (standardized regression coefficient [β] = −0.164, P = 0.004) and masticatory performance (β = −0.125, P = 0.019) had significant associations with the GOHAI score, whereas this association was not found with the OHIP score.ConclusionsAlthough the GOHAI and OHIP‐14 had a strong correlation, the GOHAI was more sensitive to the objective values of oral functions among independently living elderly persons in Japan.
Multiple myeloma in octogenarians: Clinical features and outcome in the novel agent era
Authors: Dimopoulos Meletios A. , Kastritis Efstathios , Delimpasi Sossana , Katodritou Eirini , Hatzimichael Eleftheria , Kyrtsonis Marie‐Christine , Repousis Panagiotis , Tsirogianni Maria , Kartasis Zafiris , Parcharidou Agapi , Michael Michalis , Michalis Eurydiki , Tsatalas Constantinos , Stefanoudaki Ekaterini , Hatjiharissi Eudoxia , Gika Dimitra , Symeonidis Argiris , Terpos Evangelos , Zervas Konstantinos ,   On behalf of the Greek Myeloma Study Group
Published: April 2012

AbstractBackgroundMultiple myeloma (MM) affects mainly elderly persons and because the population of octogenarians increases, it is common to treat patients ≥80 years of age. These patients are often not included in clinical trials; thus, there is limited data on their characteristics and treatment outcome.Patients and methodsWe retrospectively analyzed 682 consecutive, unselected patients with newly diagnosed symptomatic myeloma who started treatment between January 1, 2003 and December 31, 2010.ResultsWe identified 155 (23%) patients ≥ 80 years of age. Compared to patients <80 years, octogenarians had poorer performance status (P < 0.001), anemia (P = 0.006), low serum albumin (P = 0.001), and advanced ISS (P < 0.001). The median survival of patients ≥80 years was 22 months, and 14% died within 2 months from therapy initiation. The median survival of patients ≥80 years who received upfront novel agents was 26 vs. 17 months for those who did not. ECOG performance status ≤1 and frontline use of novel agents were independently associated with better survival. Response to first‐line therapy was associated with improved survival (29 vs. 16 months, P = 0.017).ConclusionsPatients ≥80 years of age present with features of advanced myeloma and impaired performance status. The addition of novel agents may improve their outcome, but careful assessment and prospective clinical trials targeting the population of elderly patients are needed.
Circulating KITD816V mutation‐positive non‐mast cells in peripheral blood are characteristic of indolent systemic mastocytosis
Authors: Kristensen Thomas , Broesby‐Olsen Sigurd , Vestergaard Hanne , Bindslev‐Jensen Carsten , Møller Michael B. ,   on behalf of the Mastocytosis Centre Odense University Hospital (MastOUH)
Published: April 2012

AbstractIt is presently accepted that the
KIT
D816V mutation is detectable in tissues with neoplastic mast cells in most patients with indolent systemic mastocytosis. In this study, neoplastic mast cells were detected in bone marrow, but not in peripheral blood, by flow cytometry in all 25 included cases of indolent systemic mastocytosis. However, the
KIT
D816V mutation was detected using mutation‐specific qPCR in both bone marrow and peripheral blood in all 25 cases, demonstrating for the first time that the
KIT
D816V mutation is consistently present in non‐mast cells in indolent systemic mastocytosis and that these cells are circulating in peripheral blood.
Effect of different disinfectants on the microhardness and roughness of acrylic resins for ocular prosthesis
Authors: Moreno Amália , Goiato Marcelo C. , dos Santos Daniela M. , Haddad Marcela F. , Pesqueira Aldiéris A. , Bannwart Lisiane C. 
Published: April 2012

Background:  Ocular prosthesis materials should have specific properties for their indication and durability; therefore, it is important to investigate their physical behaviour when affected by several disinfectants.Objectives:  This study evaluated the influence of different disinfecting solutions on the microhardness and surface roughness of acrylic resins for ocular prosthesis.Materials and Methods:  Fifty samples simulating ocular prostheses were fabricated with N1 resin and colourless resin and divided (n = 10) according to the disinfectant used: neutral soap, Opti‐free, Efferdent, 1% hypochlorite (HYC) and 4% chlorhexidine (CHX). Samples were stored in saline solution at 37°C and disinfected during 120 days. Both microhardness and roughness were investigated before, after 60 days and 120 days of disinfection and storage. Microhardness was measured using a microhardner and the roughness with a roughness device.Results:  N1 resin showed lower microhardness when compared with colourless resin (p < 0.05). HYC and CHX groups exhibited the highest change of microhardness and roughness values (p < 0.05). An increase in roughness and reduction in microhardness of ocular acrylic resins were observed after both periods of disinfection and storage (p < 0.05).Conclusion:  Both disinfection/storage periods affected the microhardness and roughness values of the samples.
I Grow Old: T. S. Eliot’s “The Love Song of J. Alfred Prufrock” andInventions of the March Hare100 Years On
Authors: Stayer Jayme 
Published: April 2012

AbstractThis essay describes the origin and significance of T. S. Eliot’s early notebook, first published in 1995 asInventions of the March Hare. Eliot’s first triumphs, including “The Love Song of J. Alfred Prufrock” and “Portrait of a Lady,” germinated in this workshop. The essay summarizes the place these early, published poems held in the criticism for 80 years, from 1915 through 1995. It then considers how the critical conversation about Eliot’s early development changes significantly with the publication of the notebook, when the unknown apprentice poems are restored alongside their more famous companions.
High Doses of Oseltamivir Phosphate Induce Acute Respiratory Arrest in Anaesthetized Rats
Authors: Kimura Satoko , Niwa Yuka , Iwajima Yui , Nagano Yuko , Yamamoto Shohei , Ohi Yoshiaki , Maeda Yasuhiro , Kurono Yukihisa , Ono Hideki , Haji Akira 
Published: April 2012

AbstractIt has been reported that one of the serious adverse events after the treatment of oseltamivir phosphate (OP) for influenza patients is sudden death resulting from cardiorespiratory arrest. To investigate the aetiology of such an adverse consequence, we examined effects of OP (expressed as free base) on blood pressure and ventilation in anaesthetized rats with vagotomy. Intravenous OP (30–200 mg/kg) caused dose‐dependent hypotension and bradycardia in spontaneously breathing animals. Concomitantly with changes in blood pressure, the tracheal airflow increased. The ventilatory rate hastened during the injection and then transiently slowed around 1 min. after the administration (transient hypopnea). Thereafter, it gradually returned to control. The hypopnea increased with increasing dose and ventilatory arrest occurred at 200 mg/kg. Intraduodenal OP (500–1000 mg/kg) provoked cardioventilatory arrest 72–218 min. after the injection. Oseltamivir carboxylate (100–200 mg/kg, i.v.), an active metabolite of OP, had no significant effect on ventilation and blood pressure. In artificially ventilated animals, intravenous OP caused slowing of the respiratory rate around 1 min. after the injection in a dose‐dependent manner. This effect of OP waned in 5 min. after the administration. The amplitude of phrenic nerve discharge was not changed at lower doses (30–100 mg/kg). The phrenic nerve stopped to discharge immediately after higher doses (150–200 mg/kg). We demonstrated that OP causes central suppression of the respiratory function in rats and suggest a relationship between the OP‐induced cardiorespiratory arrest and sudden death observed in influenza patients after taking OP.
Identification of Factors Affecting Tacrolimus Level and 5‐Year Clinical Outcome in Kidney Transplant Patients
Authors: Kim In‐Wha , Noh Hyejin , Ji Eunhee , Han Nayoung , Hong Su Hyun , Ha Jongwon , Burckart Gilbert J. , Oh Jung Mi 
Published: April 2012

AbstractThe purpose of this study was to identify and characterize the association of various clinical variables and CYP3A5 genotypes with the pharmacokinetics of tacrolimus and outcome over 1–5 years in kidney transplantation patients in Korea. A total of 129 recipients (aged 18–65 years) administered tacrolimus were genotyped for CYP3A5 (6986A>G in intron 3; rs776746). Clinical covariates and trough levels, doses and dose‐adjusted trough levels of tacrolimus, as well as complications during the 1–5 years after transplantation, were analysed. A linear mixed model was used to investigate potential factors affecting the trough levels, doses and dose‐adjusted levels of tacrolimus. We identified factors affecting chronic allograft nephropathy (CAN) and tacrolimus‐related complications. After adjusting for sex, body‐weight and doses of corticosteroids and mycophenolate mofetil, we noted that CYP3A5 genotypes had the most profound effect on the dose and dose‐adjusted trough levels of tacrolimus 1–5 years after transplantation (p < 0.001). Trough levels of tacrolimus were associated with post‐transplantation hyperlipidaemia (p < 0.05), and estimated glomerular filtration rate was associated with CAN (p < 0.05). Therefore, the CYP3A5 genotype is a variable marker for tacrolimus dose requirement, and the trough level of tacrolimus should be controlled to minimize post‐transplant hyperlipidaemia to achieve optimum outcome.
Nursing students' views of sociocultural factors in clinical learning: A qualitative content analysis
Authors: DADGARAN Ideh , PARVIZY Soroor , PEYROVI Hamid 
Published: April 2012

AbstractAim:  The aim of this study is description of nursing students' views of sociocultural factors in clinical learning.Methods:  A qualitative content analysis was conducted to describe nursing students' views of sociocultural factors in clinical learning. The participants consisted of 21 nursing students. Semi‐structured and interactive interviews were used to collect data. All the interviews were recorded and transcribed, and then, they were analyzed using Qualitative Content Analysis and Max Qualitative Data Analysis 2010.1Results:  From the transcripts, a remarkable number of primary themes, main themes, and sub‐themes emerged. The main themes consisted of elements related to “society and culture”, “family”, “staff”, and “classmates”. The themes encompassed a spectrum of facilitators of and impediments to clinical learning.Conclusion:  The findings showed that the administrators of nursing education should coordinate with faculty and staff by adopting interactive and participatory solutions, including the establishment of clinical learning teams and the transformation of hospitals into suitable sociocultural environments for education.
Standard Operating Procedures for Priapism
Authors: Burnett Arthur L. , Sharlip Ira D. 
Published: April 2012

ABSTRACT

Aim
To provide standard operating procedures for the diagnosis and management of priapism.

Methods
Review of the literature.

Main Outcome Measures
Reduction of priapism and preservation of erectile function.

Results
Priapism is a persistent penile erection that continues hours beyond, or is unrelated to, sexual stimulation. Priapism requires prompt evaluation and usually requires emergency management. There are two types of priapism: (i) ischemic (veno-occlusive or low flow), which is found in 95% of cases, and (ii) nonischemic (arterial or high flow). Stuttering (intermittent) priapism is a recurrent form of ischemic priapism. To initiate appropriate management, the physician must determine whether the priapism is ischemic or nonischemic. Necessary diagnostic steps are an accurate history, physical examination, and cavernous blood gas analysis and/or color duplex ultrasonography of the corpora cavernosa. Management of ischemic priapism should achieve resolution as promptly as possible. Initial treatment is therapeutic aspiration with or without irrigation of the corpora. If this fails, intracavernous injection of sympathomimetic drugs is the next step. Surgical shunts should be performed if nonsurgical treatment has failed. The initial management of nonischemic priapism should be observation. Selective arterial embolization is recommended for the management of nonischemic priapism in patients who request treatment. The goal of management for a patient with recurrent (stuttering) priapism is prevention of future episodes.

Conclusion
Management of priapism has become increasingly successful as scientific understanding of the pathophysiology and molecular biology of priapism improves. The key to further success in the treatment of priapism is basic research of this uncommon but potentially devastating condition.
Yield and yield stability in mixtures of productive grassland species: Does species number or functional group composition matter?
Authors: Küchenmeister Frank , Küchenmeister Kai , Wrage Nicole , Kayser Manfred , Isselstein Johannes 
Published: April 2012

AbstractIn productive agricultural grasslands the relative importance of species identity, species richness and functional group composition for production and yield stability is not clear. We, therefore, tested diversity effects in mixtures of five productive species common in temperate agricultural grasslands in a greenhouse study: Trifolium repens (legume), Lolium perenne, Dactylis glomerata (grasses) and Plantago lanceolata, Taraxacum officinale agg. (forbs). Diversity levels were (i) monoculture; (ii) all possible three‐species mixtures; and (iii) five‐species mixture. Biomass production increased with greater species richness, an effect that was interpreted as a functional response to a higher proportion of legumes in the mixtures. Species identity and functional composition influenced yield and yield stability in different ways. Larger contents of the legume in mixtures increased yield but decreased yield stability while grasses showed the opposite effect in mixtures. The biomass production of forbs was mostly small in mixtures and yield stability decreased with increasing presence of forbs. In productive agricultural grassland, functional group composition, especially the presence of legumes and grasses, seems to be more important for productivity and yield stability than diversity.
Yield‐related QTLs and Their Applications in Rice Genetic ImprovementF
Authors: Bai Xufeng , Wu Bi , Xing Yongzhong 
Published: April 2012

AbstractGrain yield is one of the most important indexes in rice breeding, which is governed by quantitative trait loci (QTLs). Different mapping populations have been used to explore the QTLs controlling yield related traits. Primary populations such as F2 and recombinant inbred line populations have been widely used to discover QTLs in rice genome‐wide, with hundreds of yield‐related QTLs detected. Advanced populations such as near isogenic lines (NILs) are efficient to further fine‐map and clone target QTLs. NILs for primarily identified QTLs have been proposed and confirmed to be the ideal population for map‐based cloning. To date, 20 QTLs directly affecting rice grain yield and its components have been cloned with NIL‐F2 populations, and 14 new grain yield QTLs have been validated in the NILs. The molecular mechanisms of a continuously increasing number of genes are being unveiled, which aids in the understanding of the formation of grain yield. Favorable alleles for rice breeding have been ‘mined’ from natural cultivars and wild rice by association analysis of known functional genes with target trait performance. Reasonable combination of favorable alleles has the potential to increase grain yield via use of functional marker assisted selection.
image

[ Yongzhong Xing (Corresponding author)]
Collimated jets from the first core
Authors: Price Daniel J. , Tricco Terrence S. , Bate Matthew R. 
Published: April 2012

ABSTRACT
We have performed smoothed particle magnetohydrodynamics (SPMHD) simulations demonstrating the production of collimated jets during collapse of 1 M⊙ molecular cloud cores to form the ‘first hydrostatic core’ in low-mass star formation. Recently, a number of candidate first-core objects have been observed, including L1448 IRS2E, L1451-mm and Per-Bolo 58, although it is not yet clear that these are first hydrostatic cores. Recent observations of Per-Bolo 58 in particular appear to show collimated, bipolar outflows which are inconsistent with previous theoretical expectations. We show that low-mass first cores can indeed produce tightly collimated jets (opening angles ≲10°) with speeds of ∼2–7 km s−1, consistent with some of the observed candidates. We have also demonstrated, for the first time, that such phenomena can be successfully captured in SPMHD simulations.
Giving an account of oneself: The PBRF and the neoliberal university
Authors: Cupples Julie , Pawson Eric 
Published: April 2012

AbstractThe New Zealand Performance Based Research Fund (PBRF) has come into being in the last decade in the wider context of the neoliberalising and corporatising of the academy. It is far more than its outward form: that is, an innocent accounting of the research‐related activities of academics for the purposes of determining institutional funding levels. But neither is it only a process that seeks (to use Judith Butler's terms) to constrain, subordinate and discipline individual academics. Drawing on her book, Giving an Account of Oneself (2005), we suggest that the PBRF can also be used to enable and sustain through creating spaces to critique neoliberalising managerialism.
Caffeine‐stimulated fatty acid oxidation is blunted in CD36 null mice
Authors: Lally J. S. V. , Jain S. S. , Han X. X. , Snook L. A. , Glatz J. F. C. , Luiken J. J. F. P. , McFarlan J. , Holloway G. P. , Bonen A. 
Published: April 2012

AbstractAim:The increase in skeletal muscle fatty acid metabolism during exercise has been associated with the release of calcium. We examined whether this increase in fatty acid oxidation was attributable to a calcium‐induced translocation of the fatty acid transporter CD36 to the sarcolemma, thereby providing an enhanced influx of fatty acids to increase their oxidation.Methods:Calcium release was triggered by caffeine (3 mm) to examine fatty acid oxidation in intact soleus muscles of WT and CD36‐KO mice, while fatty acid transport and mitochondrial fatty acid oxidation were examined in giant vesicles and isolated mitochondria, respectively, from caffeine‐perfused hindlimb muscles of WT and CD36‐KO mice. Western blotting was used to examine calcium‐induced signalling.Results:In WT, caffeine stimulated muscle palmitate oxidation (+136%), but this was blunted in CD36‐KO mice (−70%). Dantrolene inhibited (WT) or abolished (CD36‐KO) caffeine‐induced palmitate oxidation. In muscle, caffeine‐stimulated palmitate oxidation was not attributable to altered mitochondrial palmitate oxidation. Instead, in WT, caffeine increased palmitate transport (+55%) and the translocation of fatty acid transporters CD36, FABPpm, FATP1 and FATP4 (26–70%) to the sarcolemma. In CD36‐KO mice, caffeine‐stimulated FABPpm, and FATP1 and 4 translocations were normal, but palmitate transport was blunted (−70%), comparable to the reductions in muscle palmitate oxidation. Caffeine did not alter the calcium‐/calmodulin‐dependent protein kinase II phosphorylation but did increase the phosphorylation of AMPK and acetyl‐CoA carboxylase comparably in WT and CD36‐KO.Conclusion:These studies indicate that sarcolemmal CD36‐mediated fatty acid transport is a primary mediator of the calcium‐induced increase in muscle fatty acid oxidation.