bluuebunny/crossref_metadata_2025_split huggingface dataset:
ASSOCIATION OF OFFICE AND AMBULATORY BLOOD PRESSURE MONITORING WITH COGNITIVE FUNCTION AND DEMENTIA PREVALENCE
Authors: Melgarejo Jesus , Charisis Sokratis , Patil Dhrumil , Vatcheva Kristina , Mejia-arango Silvia , Mena Luis , Garcia Antonio , Alliey-rodriguez Ney , Satizabal Claudia , Chavez Carlos , Gaona Ciro , Silvia Egle , Calmon Gustavo , Mavarez Rosa , Lee Joseph , Terwilliger Joseph , Blangero John , Seshadri Sudha , Maestre Gladys 
Published: May 2024

Objective:
Blood pressure (BP) is an important risk factor for cognitive decline and dementia. However, it is unclear which measures of BP obtained from office and ambulatory BP monitoring assessments are better related with cognition and dementia. Therefore, we evaluated the association of office and ambulatory BP measures with cognitive function and dementia at baseline.

Design and method:
We included baseline information of 1435 participants aged 50y or older from a population-based study whom underwent 24-h ambulatory BP monitoring, cognitive function, and neurological assessments. Office and ambulatory BP monitoring measures included systolic BP level and short-term variability quantified using the average real variability (ARV) index. Cognitive function examination included the minimental state examination (MMSE) and selective reminder tests ([SRL], total retrieval, long-term retrieval, and delayed recall). Dementia was a clinical dementia rating scale equal or higher than 1. We performed adjusted logistic and linear regression models to evaluate the association of office and ambulatory BP monitoring measures with cognitive function and dementia.

Results:
The mean age was 63.8±10.3 and 69.1% (n=963) were women. The prevalence of dementia was 3.21 (n=46). In adjusted logistic regression models, only ARV of the 24-h (odds ratios [OR] per +1-standard deviation [SD] increase in ARV, 1.42; 95% confidence interval [CI], 1.07-1.88) and nighttime (OR, 1.37; 95% CI, 1.05-1.78) systolic BP were associated with dementia at baseline. In adjusted linear regression models, only ARV was associated with lower scores in the MMSE and the SRL tests (adjusted-mean scores per +1SD increase in ARV ranged from -0.09 to -0.06 points; P values below 0.027). These associations remained after models were additionally adjusted by the BP level (P values below 0.033)

Conclusions:
Among office and ambulatory BP monitoring measures, higher short-term variability in the 24-h and nighttime systolic BP was associated with lower cognitive function and dementia independent of the BP level. This is the first epidemiological study showing an association between short-term BP variability and dementia. Future longitudinal studies need to address whether short-term BP variability could be a potential marker for cognitive decline and might help in assessing the risk of dementia.
MICRORNA-133A AND MICRORNA-145 AS PROMISING BIOMARKERS OF HYPERTENSION MEDIATED ORGAN DAMAGE IN ADOLESCENTS WITH PRIMARY HYPERTENSION – A PRELIMINARY STUDY
Authors: Szyszka Michal , Skrzypczyk Piotr 
Published: May 2024

Objective:
Studies based on data from adults show an important role of microRNAs in the development of hypertension and their impact on hypertension-mediated organ damage (HMOD). The aim was to examine the expression of miR-21, miR-27a, miR-27b, miR-133a, and miR-145 in hypertensive pediatric patients and reveal their correlation with blood pressure parameters, properties of the arteries, and myocardial hypertrophy.

Design and method:
In 22 teenagers (18 boys, 4 girls, 15.1±1.9 years) with primary hypertension, we assessed mentioned above microRNA expression levels before and after one hour of aerobic exercise session, office and 24-hour ambulatory blood pressure and HMOD indicators, such as left ventricle mass index (LVMI), urinary albumin-creatine ratio, pulse wave velocity (PWV), and carotid intima-media thickness (cIMT). Relative microRNA expression was calculated with the 2^-δδCt method with miR-16 as endogenous control and baseline (before exercise session) microRNA expression taken as a control value.

Results:
In the studied children, we observed significant decrease in both office and 24 hour ambulatory diastolic blood pressure after one-hour exercise (82.2±8.5 vs. 78.6±8.8 [mm Hg], p=0.01 and 75.0±8.3 vs. 73.0±7.4 [mm Hg], p=0.02). In the whole group there were no significant changes in expression of the studied microRNA molecules after an exercise session. The post-exercise increase in miR-133a expression level showed a positive correlation with LVMI [g/m2.7] (R=0.491, p=0.02). Conversely, post-exercise increase in miR-145 expression correlated negatively with post-exercise both systolic and diastolic office and 24-hour blood pressure, 24-hour PWV, and cIMT (R=-0.428, p=0.047 and R=-0.430; p=0.046, and R=-0.455, p=0.033, respectively). None of the studied microRNA molecules correlated with age.

Conclusions:
1.MicroRNA-133a might be a marker of left ventricular hypertrophy in children with primary hypertension.
2. Exercise-induced change in microRNA-145 expression may lower post-exercise blood pressure and have a protective effect against arterial damage in children with primary hypertension.
3. Both miR-133a and miR-145 may be involved in epigenetic modifications in pediatric patients with primary hypertension influencing HMOD.
CHILD BLOOD PRESSURE AND RENAL FUNCTION DIFFERENCES BY SUBTYPES OF MATERNAL HYPERTENSIVE DISORDERS OF PREGNANCY
Authors: Ishikuro Mami , Obara Taku , Noda Aoi , Orui Masatsugu , Shinoda Genki , Murakami Keiko , Kikuya Masahiro , Metoki Hirohito , Kuriyama Shinichi 
Published: May 2024

Objective:
The objective of this study is to investigate the difference child blood pressure (BP) and renal function by subtypes of maternal hypertensive disorders of pregnancy (HDP).

Design and method:
The Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study is a prospective birth cohort study including pregnant women, children and their families. Using available data of children at 8 years old from December 2022 to March 2023, we analyzed the association between maternal HDP subtypes by extracted from medical record and systolic and diastolic BPs and estimated glomerular filtration rate (eGFR) collected at research facilities. Analysis of covariance adjusted for their sex, body mass index, small for gestational age were performed. Maternal grandparental hypertension and paternal hypertension for child BP, and maternal grandparental chronic nephritis and parental chronic nephritis were additionally adjusted.

Results:
A total of 684 children (357 male and 327 female) at 8 years old was included in this study. Among them, 56 children had mothers with HDP (24 gestational hypertension, 11 preeclampsia, 9 superimposed preeclampsia, 12 chronic hypertension). The mean (standard deviation) systolic/diastolic BPs and eGFR were 106.90 (10.51)/64.68 (8.77) mmHg and 110.91 (16.23) mL/min/1.73m2, respectively. Estimated systolic/diastolic BPs (standard error) of children with normotensive mothers, those with gestational hypertension mothers, those with preeclampsia mothers, those with superimposed preeclampsia mothers, and those with chronic hypertension mothers were: 106.44 (0.76)/64.58 (0.64) mmHg, 108.38 (2.11)/64.80 (1.78) mmHg, 107.59 (3.10)/64.70 (2.61) mmHg, 108.38 (3.38)/63.64 (2.85) mmHg, 112.19 (2.98)/64.58 (2.51) mmHg, respectively. Upon classification of HDP subtypes, estimated eGFR were as follows: 110.11 (1.23) mL/min/1.73m2, 111.61 (3.40) mL/min/1.73m2, 118.20 (4.99) mL/min/1.73m2, 105.13 (5.43) mL/min/1.73m2, and 119.42 (4.82) mL/min/1.73m2, respectively. The p-values were above 0.05 for the systolic and diastolic BPs and eGFR among HDP subtypes.

Conclusions:
The follow-up measurement is ongoing until 2026; therefore, further study with updated dataset is necessary and will be provided.
DIAGNOSTIC VALUE OF SERUM IRISIN LEVELS IN HYPERTENSIVE PATIENTS WITH SEVERE OBSTRUCTIVE SLEEP APNEA SYNDROME
Authors: Yili Jina , Yao Xiaoguang , Li Nanfang 
Published: May 2024

Objective:
To observe the diagnostic value of serum irisin level in patients with hypertension for severe obstructive sleep apnea syndrome.

Design and method:
A total of 156 hypertensive patients were selected from the Hypertension Center of the People 's Hospital of Xinjiang Uygur Autonomous Region from September 2019 to January 2020. Baseline data, PSG and ABPM were collected and serum irisin levels were measured. According to AHI, the patients were divided into severe OSAS group (n=79 cases) and non-severe OSAS group (n=77 cases).

Results:
Male patients in severe OSAS group were significantly more than those in non-severe OSAS group, and abdominal circumference and neck circumference in severe OSAS group were greater than those in non-severe OSAS group. Serum irisin concentration in severe OSAS patients was lower than that in non-severe OSAS group, and the difference was statistically significant(14.94 ng/ml vs 42.34 ng/ml, p < 0.001). Serum irisin concentration was negatively correlated with AHI (r=-0.359, p < 0.01). The critical value of serum irisin concentration was 38.07 mg/ml by ROC curve, the AUC is 0.761, the sensitivity was 86.07%, the specificity was 61.07%, the positive predictive value was 69.38%, and the negative predictive value was 81.03%.

Conclusions:
In hypertensive population, the serum irisin concentration of OSA patients was negatively correlated with the severity of OSAS. Serum irisin level can be used as a diagnostic index for severe OSAS patients.
EVALUATION OF EFFICACY OF ANTIHYPERTENSIVE THERAPY FOR PSYCHOEMOTIONAL STATUS IN PATIENTS WITH ARTERIAL HYPERTENSION
Authors: Makhkamova Nargiza , Xasanova Kamola 
Published: May 2024

Objective:
To evaluate the effectiveness of antihypertensive therapy on the level of personal, reactive anxiety and depression in patients with hypertension (AH).

Design and method:
The study included 75 patients with AH aged 39-69 years (average age 54 ± 3 years). During the study, the causes of symptomatic AH, baseline antihypertensive therapy was optimized. AH was diagnosed by daily monitoring of blood pressure (DMBP) using the TONOPORT device (Germany) according to the standard method. At baseline and in the course of 3-month antihypertensive therapy (AHT) with valsartan (160 mg per day) and indapamide 2.5 mg per day, the level of personal and reactive anxiety on the State-Trait Anxiety Inventory, STAI and depression on the Zung Self-Rating Depression Scale were determined.

Results:
At baseline, the indicators of personal and reactive anxiety in patients with AH were noticeably higher (27 ± 1 point and 26 ± 2 points). At the same time, the indicators of reactive and especially personal anxiety closely correlated with the average daily indicators of systolic BP (r - 0.47 at p < 0.05 and 0.54 at p < 0.01). Insufficient decrease in BP at night was more clearly associated with the severity of depression and anxiety detected on the Zung Self-Rating Depression Scale (r -0.39, at p < 0.05). The increase in personal anxiety was clearly associated with an increase in the average daily variability of systolic BP.
As a result of the combined AHT, a significant decrease in the scores on the used scales was observed. The measures of personal and reactive anxiety were 22 ± 2 and 21 ± 1 point, respectively, (p < 0.01 from baseline). The increase in personal anxiety was clearly associated with an increase in the average daily variability of systolic BP (r -0.46, p < 0.05).

Conclusions:
The degree of arterial hypertension and daily variability is associated with an increase in the level of anxiety and severity of depressive disorders in patients with AH. Adequate AHT contributes to the improvement of psychoemotional status indicators in patients with AH.
A COMPARISON BETWEEN THE TWO METHODS OF MAGNESIUM SULFATE ADMINISTRATION FOR DURATION OF 12 VERSUS 24 H AFTER DELIVERY IN PATIENTS WITH SEVERE PREECLAMPSIA
Authors: Kashanian Maryam , Sahraian Ghazal 
Published: May 2024

Objective:
Preeclampsia is one of the very serious and important complications of pregnancy which may culminate in serious maternal mortality and morbidity. For preventing eclampsia and convulsions, magnesium sulfate (Mg So4) is the medication of choice. As a standard method, it will be continued up to 24 hours after delivery of the baby. Shortening the duration of its administration can reduce the duration of hospital stay, risk of magnesium sulfate (Mg sulfate) toxicity and adverse effects, cost, duration of treatment, and patient satisfaction.
The purpose of the present study was to compare the 2 methods of magnesium sulfate administration for a duration of 12 VS 24 hours after delivery in patients with severe preeclampsia.

Design and method:
The study was performed as a randomized clinical trial on 182 cases of severe preeclampsia. They were randomly assigned into the 2 groups. In one group, Mg sulfate was prescribed for 12 hours after delivery and in the other group, it was prescribed for 24 hours after delivery. The dosage of Mg sulfate was similar in both groups and only the duration of administration was different.
Both groups were compared for the occurrence of convulsions and other adverse effects.

Results:
The women of the 2 groups did not have significant differences according to age, BMI, Parity, gravidity, or gestational age at the time of delivery. Also, systolic blood pressure, diastolic blood pressure, antihypertensive use, previous diabetes and renal disorders, gestational diabetes, and proteinuria were similar in both groups before treatment. One woman had a convulsion in the 12 hours group and Mg SO4 was continued for 24 hours in this case. Blood pressure, urine volume, and laboratory indexes did not show significant differences between the 2 groups before and after treatment. Also, adverse effects were similar in both groups. Pain at the injection site was less in the 12-hour group (P=0.048).

Conclusions:
Administration of Mg sulfate for 12 hours after delivery should be considered somehow as effective as 24 24-hour prescription for preventing convulsion after delivery.
PREVALENCE AND OUTCOME OF PRIMARY ALDOSTERONISM IN PBMAH: A SINGLE CENTER STUDY AND A SYSTEMATIC REVIEW OF THE LITERATURE
Authors: Panarelli Annalisa , Nowak Elisabeth , Adam Pia , Schweizer Junia , Stuefchen Isabel , Zopp Stephanie , Reincke Martin 
Published: May 2024

Objective:
Primary bilateral macronodular adrenocortical hyperplasia (PBMAH), characterized by benign adrenocortical macronodules and variable levels of cortisol excess, can also lead to an excess of mineralocorticoids, although there is only anecdotal evidence.
To assess the prevalence and characteristics of primary aldosteronism (PA) in patients with PBMAH.

Design and method:
We conducted a systematic review according to the PRISMA guidelines. We reviewed single case reports and case series of patients with PBMAH and PA in Pubmed, Embase and Cochrane from database inception to December 2023. PBMAH was defined radiologically as at least 1 bilateral adrenal nodule of at least 10 mm. Findings were compared to patients with PBMAH without PA derived from LMU Hospital and literature.

Results:
1018 articles were screened, and 36 articles were assessed for eligibility. We identified 18 articles (8 single case reports and 10 case series), resulting in 68 cases with PBMAH with PA. Of those, 12 had cosecretion of cortisol. The prevalence of PA in PBMAH, in six studies (166 patients), ranged from 2-44%. The median age at diagnosis was 51.5 (47.5-56.2). The majority of patients with PBMAH and PA were male compared to patients with PBMAH without PA (59% vs 39%, p= 0.0295).
At baseline, the mean arterial pressure was 112 mmHg (113-133) and the median duration of hypertension was 108 months (48-135). The serum aldosterone concentration and plasma renin activity were 253 ng/l (159-436) and 0.23 ng/ml/h (0.16-0.44), respectively. Adrenal nodules were smaller in patients with PBMAH with PA compared to patients with PBMAH without PA (22 vs 30 mm, p=0.0498).
Treatment modality was reported in 30 cases: 28 patients underwent adrenalectomy (two bilateral, two subtotal, and 24 unilateral) and two received mineralocorticoid receptor antagonists (MRA). In comparison, fewer patients with PBMAH without PA underwent adrenalectomy (54/106, p=0.0005).

Conclusions:
PA in PBMAH appears to be more frequent than previously thought. Multicenter studies will help to clarify the association between these conditions and the most appropriate treatment modality.
PREVALENCE AND CLINICAL CHARACTERISTICS OF COMORBID HYPERTENSION AND CORONARY ARTERY DISEASE IN CHINA, 2008-2018
Authors: Xue Hao , Wang Chi , Xin Qian 
Published: May 2024

Objective:
Data on the prevalence of patients with comorbid hypertension and coronary artery disease (HT-CAD) in Chinese population is sparse. The current study aims to investigate the prevalence of hypertension in patients with CAD, clinical characteristics of patients with HT-CAD, and their temporal change during 2008 to 2018 in Chinese population.

Design and method:
This cross-sectional study was conducted in Chinese PLA General Hospital, a tertiary hospital that gathering nationwide patients in Beijing, China. A total of 32,355 CAD patients with and without hypertension admitted from 5 August 2008 to 22 July 2018 were identified in the current study. Among these patients, 29.57% were local residents in Beijing and 70.43% were from other 30 provinces of China (Figure 1). The demographic characteristics, diagnosis records, relevant examinations, and treatment patterns were obtained from the hospital information system. We analyzed the prevalence, blood pressure control, clinical characteristics, and their temporal change of patients with HT-CAD.

Results:
The overall prevalence of HT-CAD in patients with CAD was 64.12% (n=20,747) and did not significantly change during 2008 to 2018 (Figure 2). Higher comorbidity rate was observed in elderly and women. Among patients with HT-CAD, the blood pressure was controlled at <140/90 mmHg in 52.39% and <130/80 mmHg in 27.03%. The control rate of <130/80 mmHg increased during 2008 to 2018 (P for trend =0.02), whereas the control rate of <140/90 mmHg did not change significantly (P for trend =0.84) (Figure 2). Compared with CAD patients without hypertension, patients with HT-CAD had higher prevalences of cardiovascular-related risk factors and comorbidities, including diabetes mellitus, anemia, hyperuricemia, stroke, chronic kidney disease, peripheral arterial disease, and atrial fibrillation (Figure 3). Most of these cardiovascular-related comorbidities showed an rising trend over the study period (Figure 4), indicating worse prognosis in patients with HT-CAD and higher financial burden for health care system.

Conclusions:
Hypertension is the most common comorbidity in Chinese patients with CAD. Patients with HT-CAD have an increasing health burden and should be paid with special attention on the intensive blood pressure control and targeted management for risk factors and comorbidities.
BLOOD PRESSURE LOWERING PATTERNS DURING HOSPITALIZATION AND RISK OF REHOSPITALIZATION FOR ANGINA IN PATIENTS WITH CORONARY ARTERY DISEASE AND HYPERTENSION
Authors: Xin Qian , Wang Chi , Xue Hao 
Published: May 2024

Objective:
The present study aimed to examine the association of blood pressure (BP) lowering patterns during hospitalization with rehospitalization for angina in patients with coronary artery disease (CAD) and hypertension.

Design and method:
This prospective cohort study was conducted in PLA General Hospital, Beijing, China. We included 730 patients with CAD and hypertension, who were hospitalized between August 2020 and September 2022. The lowering patterns of systolic blood pressure (SBP)/diastolic blood pressure (DBP) during hospitalization were identified according to BP level on admission, BP level on discharge, and the difference between them: normal-stable, more-intensive reduction, less-intensive reduction, and non-reduced (Figure 1). The outcome was rehospitalization for angina, which was obtained from telephone interview. We used Cox proportional hazards regression to estimate the risk of rehospitalization for angina according to the BP lowering patterns.

Results:
We identified 90 cases of rehospitalization for angina in a median 22.5-month follow-up. Patients with more-intensive SBP reduction had the lowest incidence rate of rehospitalization for angina, followed by those with normal-stable SBP, less-intensive SBP reduction, and non-reduced SBP (Table 1). After adjusting for potential confounders, we found that compared with patients with more-intensive SBP reduction, the hazard ratios and 95% confidence intervals of rehospitalization for angina were 1.39 (0.73-2.62) for patients with normal-stable SBP (P =0.32), 2.32 (1.13-4.77) for patients with less-intensive SBP reduction (P =0.02), and 2.82 (1.38-5.75) for patients with non-reduced SBP (P =0.004) (Table 1). However, analysis on lowering patterns of DBP did not generate statistically significant results (Table 1).

Conclusions:
SBP lowering patterns during hospitalization in patients with CAD and hypertension were associated with the risk of rehospitalization for angina. These results highlighted the importance of intensive in-hospital BP control in patients with CAD and hypertension.