bluuebunny/crossref_metadata_2025_split huggingface dataset:
Efficacy of highly bioavailable oral curcumin in asymptomatic or mild COVID-19 patients: a double-blind, randomized, placebo-controlled trial
Authors: Kishimoto Atsuhiro , Komiyama Maki , Wada Hiromichi , Satoh-Asahara Noriko , Yamakage Hajime , Ajiro Yoichi , Aoyama Hiroki , Katsuura Yasuhiro , Imaizumi Atsushi , Hashimoto Tadashi , Sunagawa Yoichi , Morimoto Tatsuya , Kanai Masashi , Kakeya Hideaki , Hasegawa Koji 
Published: June 2024

Abstract
Introduction
Even after the peak of the COVID-19 pandemic, the number of mild cases remains high, requiring continuous control. Curcumin, owing to its anti-inflammatory properties, can suppress vital proliferation and cytokine secretion in animal models. We developed a highly absorbable curcumin, curcuRouge® (cR), which is approximately 100 times more orally bioavailable than conventional curcumin. We evaluated the effect of cR on the inhibition of disease progression in asymptomatic or mildly symptomatic COVID-19 patients.

Methods
This study evaluated the effect of 7-day oral intake of cR (360 mg twice daily). Patients within 5 days of COVID-19 diagnosis were randomly assigned to a placebo or cR group in a double-blind manner.

Results
Primary endpoint events [body temperature (BT) ≥ 37.5 °C and saturation of percutaneous oxygen (SpO2) < 96%] were fewer than expected, and the rate of these events was 2.8% in the cR group (2/71) and 6.0% in the placebo group (4/67); hazard ratio (HR) = 0.532, 95% confidence interval (CI) 0.097–2.902. Patients receiving cR tended to take fewer antipyretic medications than those receiving placebo (HR = 0.716, 95% CI 0.374–1.372). Among patients with a normal range of BT at baseline, the BT change rate was significantly (p = 0.014) lower in the cR group (− 0.34%) versus placebo (− 0.01%).

Conclusion
The relative suppression of event rates and antipyretic medications taken, and significant decrease of subclinical BT support the anti-inflammatory effects of cR in asymptomatic or mildly symptomatic patients with COVID-19.
Trial registration: Japan Registry of Clinical Trials (CRB5200002).
Deciphering the landscape of lncRNA-driven ceRNA network in schizophrenia etiology
Authors: Mukhopadhyay Anirban , Singh Prithvi , Dohare Ravins , Thelma B. K. 
Published: June 2024

Abstract
Background
The unifying hypothesis of competing endogenous RNA (ceRNA) wherein crosstalk between coding (mRNAs) and long non-coding RNAs (lncRNAs) via microRNA (miRNA) response elements, creates a pervasive regulatory network across the transcriptome, has been implicated in complex disorders including schizophrenia. Even with a wide range of high-throughput data, the etiology of schizophrenia remains elusive, necessitating a more holistic understanding of the altered genetic landscape, shifting focus from solely candidate gene studies and protein-coding variants.

Objective
We developed lncRNA-associated ceRNA networks to elucidate global molecular/regulatory signatures underlying schizophrenia using diverse data in the public domain.

Methods
Microarray dataset associated with peripheral blood mononuclear cells (PBMCs) of schizophrenia and control patients was used to identify differentially expressed mRNAs. Weighted gene co-expression network analysis (WGCNA) was used to identify highly correlated hubs, and genes from these overlapping Kyoto Encyclopedia of Genes and Genomes (KEGG) and gene ontology (GO) term genesets were considered key mRNA players. StarBase, Human MicroRNA Disease Database, and miRWalk were used to derive mRNA-miRNA and miRNA-lncRNA relationships. Finally, the key mRNAs, interacting lncRNAs and miRNAs were chosen to reconstruct sub-ceRNA networks based on network centrality scores.

Results
Bioinformatics analysis revealed the involvement of three differentially expressed mRNAs, namely ADRA1A, HAP1 and HOMER3 in the schizophrenia ceRNA networks with lncRNAs NEAT1, XIST, and KCNQ1OT1 modulating their activity by a suggestive sequestering of miR-3163, miR-214-3p and miR-2467-3p, respectively.

Conclusions
Furthermore, based on contextual evidence, we propose how ceRNAs could orchestrate crosstalk between neurostructural dynamics and immune/inflammatory processes and enable unifying these disparate models of schizophrenia etiology.
Relief of double-J stent-related symptoms: a comparison between mirabegron, tamsulosin and solifenacin
Authors: Elmarakbi Akrm A. , Elsayed Osama M. , Mohamed Tamer R. , Lotfy Amr M. 
Published: June 2024

Abstract
Background
Inserting ureteral stents is a routine intervention that often results in problems. The cornerstone for treating stent-related symptoms is pharmacological therapy. This study was conducted to evaluate and to compare the effectiveness of mirabegron, tamsulosin, solifenacin and control in reducing double-J stent-related symptoms.

Results
Patients were evaluated preoperatively, one week after stent insertion and two weeks after the start of medications by the Ureteral Stent Symptom Questionnaire (USSQ), International Prostate Symptom Score (IPSS), overactive bladder questionnaire (OAB-q) and visual analogue pain scale (VAPS). Solifenacin and mirabegron groups had significantly lower sexual scores after the 1st and 2nd weeks post-operatively (PO) when compared with the control group. Mirabegron group had significantly lower sexual scores after 1st and 2nd weeks PO when compared with patients in tamsulosin and solifenacin groups. Patients in mirabegron group had significantly fewer additional problems after the 1st and 2nd weeks PO when compared with patients in the control and tamsulosin groups.

Conclusions
To sum up, mirabegron was found to be superior to solifenacin in lowering urinary symptoms scores, sexual performance scores and work performance scores at both first and second weeks post-operatively. Mirabegron is a good alternative choice for SRSs when tamsulosin or solifenacin is ineffective or not tolerated.
Architectural Design Studio activities in times of pandemic. Alternative models and tools for managing mixed-mode teaching
Authors: Veronica Ferrari  
Published: June 2024

This contribution deals with the experience of the Architectural Design in Historical Context Studio held by professors Luigi Spinelli, Barbara Bogoni and Eduardo Souto de Moura, that takes place in the second semester of the first year of the Master of Science in Architectural Design and History - AUIC school of the Politecnico di Milano. The course, held in English, is part of an international program that welcomes students from all over the world, offering them the opportunity to fully experience the integration of the different disciplinary components of design practice. The course aims to learn the fundamentals of architectural design and the application to the historical context of the city of Mantova of the theoretical, analytical, historical and instrumental knowledge that students have had the opportunity to develop and increase during their studies, to reach the definition of an architectural project developed in all its parts.
From pencil to mouse, from face to screen. A teaching experience in times of Covid 19
Authors: Pierre-Antoine Sahuc  
Published: June 2024

2020 became a landmark year in more ways than one. The global health crisis linked to the coronavirus epidemic completely disrupted our behaviour. Travel was restricted to only strictly necessary journeys and these were limited to close to home. Some activities were allowed but social distancing was enforced. In a few days, everything came to halt for an indefinite period of time. In France, the first measures, which began in March, profoundly changed our lifestyles. The country entered into a lockdown phase and this situation had a profound impact on the way we consumed, worked and travelled. We no longer had access to places of culture, educational establishments. As a teacher in an architecture school, these interdictions were the start of a radical upheaval in the way we taught. How could we react to these measures that would take effect only a few hours later? Were we well prepared?
L'utilità dell'apparentemente inutile. La casa per un uccello, un aquilone, un gioco
Authors: Gustavo Adolfo Carabajal  
Published: June 2024

L’esperienza dei workshop diventa occasione per frequentare l’argomento dell’utilità dell’apparentemente inutile: Cosa si ottiene affrontando i problemi del progetto di una casa per un uccello, un aquilone o un gioco? Si avvia un’indagine sulle tecniche del progetto e sulla sua rappresentazione, con l'obiettivo di approfondire gli aspetti essenziali del lavoro dell'architetto: come si inizia, come avviene il processo di ideazione, il modo di documentarsi, il tema della scala, il ruolo della struttura, i materiali, gli elementi naturali e le componenti ambientali specifiche di un luogo. Questi esercizi sono il luogo della collezione dei materiali per una enciclopedia non scrivibile dell'ispirazione, dell'immaginazione o addirittura delle decisioni felicidelle quali parlano.
La città come teatro
Authors: Jonathan Kirschenfeld  
Published: June 2024

Il lavoro di progettazione del nostro ufficio nel corso degli ultimi 15 anni comprende social housing, piscine pubbliche e progetti di teatri. Questi progetti apparentemente distanti condividono un filo comune che attraversa la loro forma concettuale se non fisica: il concetto di “stanza urbana” come teatro. In ogni caso, sia che si tratti di una piscina, di un teatro o di un’abitazione, mobili o adattabili a diversi siti, nel corso di questi progetti sono privilegiati gli spazi cosiddetti di “impegno sociale”. Queste stanze urbane, nelle parole di Aldo Rossi, agiscono per approntare la scena per il teatro della vita quotidiana.
Architettura e Narrativa. Il dialogo del tempo, dello spazio e dell’uomo
Authors: Anna Conzatti  
Published: June 2024

Come via più antica dell’interazione fra le persone, la narrazione è una forma archetipa, al pari del costruire, all’interno della vita quotidiana dell’uomo. Quest’ultima si arricchisce attraverso il racconto, e si sublima tramite l’esperienza spirituale del vivere lo spazio. Distanti sul piano della forma e della struttura, della pesantezza e della impalpabilità, narrazione e architettura appaiono inconciliabili, eppure oggi, mentre nella contemporaneità ogni esperienza umana viene consumata dalla rapidità del tempo, queste due forme di comunicazione si ritrovano ad indagare insieme il senso del tempo, dello spazio e dell’esistenza umana. Insieme giungono ad una nuova forma di percezione che va oltre il linguaggio e si nutre della sensibilità dell’architetto, ma anche della vita che essi sono tenuti ad alimentare e a produrre all’interno di uno spazio raccontabile.
Depositare la memoria. Dal museo-deposito allo storage
Authors: Federica Visconti  
Published: June 2024

Il testo intende analizzare l’idea di museo come deposito proposta da Louis Kahn nel progetto non realizzato per la de Menil Foundation in Texas, preceduta dalle realizzazioni per la Yale University nel Connecticut e del Kimbell Art Museum a Fort Worth. Analizzando il significato etimologico della parola ‘deposito’ come atto o luogo per la conservazione e la trasmissione della memoria si vuole stabilire un ponte con alcuni fenomeni del contemporaneo nell’epoca del World Wide Web e, in particolare, con l’opera di musealizzazione dell’architettura e della città proposta dal regista britannico Peter Greenaway per interrogarsi infine, anche nell’epoca del digitale, sulla necessità dello spazio per la rappresentazione dei valori di una comunità. The paper aims to analyse the idea of ‘museum as storage’ proposed by Louis Kahn in the unbuilt project for the de Menil Foundation in Texas preceded by the constructions for Yale University in Connecticut and of the Kimbell Art Museum in Fort Worth. By analysing the etymological meaning of the word ‘storage’ (in Italian, deposito) as the act or the place for preservation and transmission of the memory, a link is established with some contemporary phenomena in the era of the World Wide Web and, in particular, with the work of musealization of architecture and the city proposed by the British director Peter Greenaway, in order to finally question, also in the digital age, the need of the space for the representation of the values of a community.
La rovina come museo del palinsesto del luogo. Il progetto di ABDR per il Mausoleo di Augusto
Authors: Rachele Lomurno  
Published: June 2024

Nelle città stratificate mediterranee le rovine archeologiche riaffiorano in un contesto mutato rispetto a quello a cui appartenevano e ci trasportano in tempi di cui rievocano la memoria. Al loro valore rammemorativo, tuttavia, si aggiunge un valore potenziale che induce a considerarle delle forme aperte, disponibili ad alimentare la ricerca compositiva dell’architettura contemporanea. Questa duplice valenza, di rammemorare il passato e di suggerire nuove trasformazioni, è intimamente legata anche alla definizione di museo. Nel progetto di ABDR proposto in occasione della consultazione internazionale del 2006 per il Mausoleo di Augusto e piazza Augusto Imperatore, la rovina archeologica riacquista un senso contemporaneo, divenendo essa stessa museo del complesso palinsesto del luogo.
Due lezioni da un terremoto. 1 - Città estrema 2 - Il Borgo
Authors: Lucio Valerio Barbera  
Published: June 2024

La città di Napoli e un piccolo paese campano, Castelnuovo di Conza, furono ambedue colpiti dal terremoto del 23 novembre del 1980. Napoli per la sua dimensione sociale e Castelnuovo per la sua posizione nel cratere del sisma, divennero luoghi emblematici del dramma e della ricostruzione. L’autore dell’articolo partecipò con ruoli di responsabilità alla progettazione degli interventi di ricostruzione e riqualificazione sia nella città di Napoli che nel borgo di Castelnuovo. Nelle pagine che seguono egli cerca di trarre alcuni insegnamenti dalla complessa sua esperienza progettuale.
Terremoti, calamità naturali, strategie di ricostruzione
Authors: Enrico Bordogna  
Published: June 2024

Tema del saggio è la strategia di ricostruzione dopo il sisma in Italia Centrale dell’estate-autunno 2016. Dopo una ricognizione dei principali terremoti in Italia nel secolo scorso, da Messina, 1908, all’Emilia Romagna, 2012, il testo esamina il caso-studio del nucleo storico di Amatrice, borgo murato con insediamento di crinale di origine federiciano-angioina. A fronte della tabula rasa lasciata dal sisma, la ricostruzione ex-novo dell’intero borgo storico si scontra col problema, teorico e operativo, del conflitto tra “dov’era, com’era” e rischio di “falso storico”, che il saggio affronta sia in termini teorici che attraverso la verifica operativa del progetto di architettura.
Combinare globalismo, futuro a lungo termine e sensibilità storiche: L’audacia di Constantinos Doxiadis
Authors: Ray Bromley  
Published: June 2024

Constantinos Doxiadis ha dedicato gran parte della sua vita alla pianificazione urbana e regionale. Il suo lavoro era globalizzato, futuristico e straordinariamente ambizioso, eppure era affascinato dai contesti locali, dalla storia e dalle civiltà antiche. La Doxiadis Associates, la società di consulenza internazionale con sede ad Atene da lui fondata a metà degli anni ‘50, ha portato a termine progetti in oltre 40 paesi. Il suo movimento Ekistics aveva soci in tutto il mondo e ha attirato migliaia di studenti e partecipanti alle conferenze in Grecia. Dopo una malattia di quattro anni, morì un anno prima della prima Conferenza delle Nazioni Unite sull’habitat, tenutasi a Vancouver nell’estate del 1976, ma concluse il suo prolifico record di pubblicazioni con quattro libri da presentare alla conferenza.
L’architettura dei Balcani. Lontano da dove?
Authors: Prandi Enrico 
Published: June 2024

Questo editoriale esplora la percezione della distanza dei territori balcanici nonostante la loro vicinanza geografica. Il processo di autodefinizione di questi territori, recentemente suddivisi, è analizzato come un arricchimento architettonico anziché un impoverimento. La diversità architettonica è vista come sinonimo di scelta e libertà, testimoniando culture che si sovrappongono nel tempo. Gli articoli cercano di riportare l'attenzione agli studiosi su un contesto spesso misconosciuto. Con questo numero la rivista FAM si propone di porre domande anziché fornire certezze, sottolineando l'importanza di continuare a esplorare e comprendere l'architettura dei Balcani.
Men's involvement in birth preparedness and complication readiness in Dessie Zuria, northeast Ethiopia: a community-based cross-sectional study
Authors: Assefaw Mandefro , Tefera Zenebe , Gashaw Wondimnew , Ayalew Sindu , Gebregzabher Tadesse , Habtie Eyaya 
Published: June 2024

Background/Aims Rates of maternal mortality and morbidity remain high in low- and middle-income countries, despite the creation of strategies to reduce the rate of preventable causes of death. Involving women's partners in maternity care is an important intervention to promote maternal and neonatal health during pregnancy, labour and birth. This study's aims were to assess factors associated with husbands' involvement in birth preparedness and complication readiness in Dessie Zuria, northeast Ethiopia. Methods A community-based cross-sectional study was conducted in Dessie Zuria, among the male partners of women of reproductive age who had given birth within the last year. A total of 634 respondents were included. Data were collected using a pretested questionnaire through face-to-face interviews. Binary logistic regression was implemented to assess factors associated with men's involvement. Results Around half (53.1%) of the participants had been involved in birth preparedness and complication readiness. Significantly associated factors included having formal education (P=0.001), having spouses who could read and write (P=0.003) or who had formal education (P=0.002), having 3–4 children (P=0.031), living within 10km of a health institution (P=0.002), and having good knowledge of danger signs in pregnancy (P=0.005), labour and birth (P=0.001). Conclusions Men's involvement in birth preparedness and complication readiness was low. Educating couples and raising awareness of the warning indicators of pregnancy, labour and the postpartum period are important interventions to improve men's involvement.
Knowledge and practice of informal caregivers on pressure injury prevention and treatment among patients receiving palliative care
Authors: BaniHani Heyam , Alnaeem Mohammad Minwer , Saleh Mohammad , Nashwan Abdulqadir J 
Published: June 2024

Background: Pressure injuries (PIs) are prevalent in palliative care. Lack of knowledge and skills among informal caregivers on PI prevention and management contributes significantly to the occurance or deterioration of PIs. Aim: The aims of this study were to: (1) determine the level of knowledge and practices of informal caregivers on PI prevention and treatment; (2) explore the socio-demographic characteristics of informal caregivers that influence PI prevention and treatment among patients who need palliative care. Methods: The quantitative cross-sectional descriptive design was used to collect data from 146 informal caregivers, and a valid and reliable questionnaire was used. Results: A total of 146 informal caregivers of patients with PI completed the study. Most participants had a relatively low level of PI prevention, treatment knowledge and practice. Participants who were older than 28 years, working for the government and married had significantly better knowledge and practice of PI prevention and treatment than other participants. Conclusion: Information for informal caregivers in different settings about PI prevention and treatment is needed. Informal caregivers need to acquire more professional practices and knowledge to improve the quality of patient care.
Preoperative CT improves the assessment of stability in trochanteric hip fractures
Authors: Woldeyesus Thomas A. , Gjertsen Jan-Erik , Dalen Ingvild , Meling Terje , Behzadi Mehdi , Harboe Knut , Djuv Ane 
Published: June 2024

AimsTo investigate if preoperative CT improves detection of unstable trochanteric hip fractures.MethodsA single-centre prospective study was conducted. Patients aged 65 years or older with trochanteric hip fractures admitted to Stavanger University Hospital (Stavanger, Norway) were consecutively included from September 2020 to January 2022. Radiographs and CT images of the fractures were obtained, and surgeons made individual assessments of the fractures based on these. The assessment was conducted according to a systematic protocol including three classification systems (AO/Orthopaedic Trauma Association (OTA), Evans Jensen (EVJ), and Nakano) and questions addressing specific fracture patterns. An expert group provided a gold-standard assessment based on the CT images. Sensitivities and specificities of surgeons’ assessments were estimated and compared in regression models with correlations for the same patients. Intra- and inter-rater reliability were presented as Cohen’s kappa and Gwet’s agreement coefficient (AC1).ResultsWe included 120 fractures in 119 patients. Compared to radiographs, CT increased the sensitivity of detecting unstable trochanteric fractures from 63% to 70% (p = 0.028) and from 70% to 76% (p = 0.004) using AO/OTA and EVJ, respectively. Compared to radiographs alone, CT increased the sensitivity of detecting a large posterolateral trochanter major fragment or a comminuted trochanter major fragment from 63% to 76% (p = 0.002) and from 38% to 55% (p < 0.001), respectively. CT improved intra-rater reliability for stability assessment using EVJ (AC1 0.68 to 0.78; p = 0.049) and for detecting a large posterolateral trochanter major fragment (AC1 0.42 to 0.57; p = 0.031).ConclusionA preoperative CT of trochanteric fractures increased detection of unstable fractures using the AO/OTA and EVJ classification systems. Compared to radiographs, CT improved intra-rater reliability when assessing fracture stability and detecting large posterolateral trochanter major fragments.Cite this article: Bone Jt Open 2024;5(6):524–531.