bluuebunny/crossref_metadata_2025_split huggingface dataset:
Risk Factors for the Development of Metachronous Liver Metastasis in Colorectal Cancer Patients After Curative Resection
Authors: Chuang Shih‐Chang , Su Yu‐Chung , Lu Chien‐Yu , Hsu Hung‐Te , Sun Li‐Chu , Shih Ying‐Ling , Ker Chen‐Guo , Hsieh Jan‐Sing , Lee King‐Teh , Wang Jaw‐Yuan 
Published: December 2010

AbstractBackgroundMetachronous liver metastasis (MLM) occurs in 20–40% of colorectal cancer (CRC) patients following surgical treatment. The aim of the present study was to determine the risk factors affecting the development of MLM in CRC patients following curative resection.MethodsA total of 1,356 patients who underwent curative intent resection for CRC were retrospectively studied. Of these patients, those who with 30 days postoperative mortality (n = 23), incomplete medical record (n = 32), synchronous liver metastasis (n = 148) and UICC stage IV (n = 54) were excluded, and finally 1,099 patients were analyzed, including 977 patients without liver metastasis and 122 patients with MLM‐only. Clinical and pathological records for each patient were reviewed from medical charts. The clinicopathologic characteristics of 1,099 patients were investigated.ResultsThe median timing of developing MLM was 13 months with a range of 4 to 79 months. Univariate analysis identified that preoperative serum carcinoembryonic antigen (CEA) level, depth of invasion, lymph nodes metastasis, vascular invasion, and perineural invasion were significantly correlated with the development of MLM (all P < 0.05). Meanwhile, a multivariate analysis showed that preoperative serum carcinoembryonic antigen (CEA) level > 5 ng/ml (Odds Ratio [OR] = 1.591; 95% Confidence Interval [CI], 1.065–2.377; P = 0.024), tumor depth (OR = 2.294; 95% CI, 1.103–4.768; P = 0.026), positive lymph node metastasis (OR = 2.004; 95% CI, 1.324–3.031; P = 0.001) and positive vascular invasion (OR = 1.872; 95% CI, 1.225–2.861; P = 0.004) were independent prognostic factors contributing to the occurrence of MLM.ConclusionsThe present study demonstrates that preoperative serum CEA level, tumor depth, lymph node metastasis, and positive vascular invasion could affect the occurrence of MLM in CRC patients following curative resection, and thus could help to define these high‐risk patients who would benefit from enhanced surveillance and therapeutic program(s).
Analysis of the Clinicopathologic Features of Papillary Thyroid Microcarcinoma Based on 7‐mm Tumor Size
Authors: Lee Kwan Ju , Cho Yun Jung , Kim Say Jun , Lee Sang Chul , Kim Jeong Goo , Ahn Chang Joon , Lee Dong Ho 
Published: December 2010

AbstractBackgroundWe examined the clinicopathologic features of papillary thyroid microcarcinomas (PTMCs) measuring ≤7 mm and compared them with those of PTMCs >7 mm.MethodsBetween January 2007 and June 2009, a total of 275 patients with PTMCs underwent surgery. They were divided into two groups. Group I included patients with tumors ≤7 mm, and group II included those with tumors >7 mm but ≤10 mm. We compared the two groups’ clinicopathologic features.ResultsTotal thyroidectomy was more often performed in group II (p = 0.003). Central lymph node metastases were identified in 30.6% of the patients in group I and in 47.8% of the patients in group II (p = 0.005). A statistically significant difference between the two groups was also found for capsule invasion (p < 0.0001), extrathyroidal extension (p = 0.005), and lymphovascular invasion (p = 0.025). On the multivariate analysis, central lymph node metastasis was the only independent factor associated with tumor size.ConclusionA PTMC ≤7 mm is less likely to have aggressive features, including central lymph node metastasis, capsule invasion, extrathyroidal extension, and lymphovascular invasion, than a PTMC >7 mm. Because the aggressiveness of PTMC was found mainly in the patients with tumors >7 mm, we think that a cutoff value of 7 mm may be considered the threshold of aggressiveness of PTMCs.
Computed Tomography Volumetric Fat Parameters versus Body Mass Index for Predicting Short‐term Outcomes of Colon Surgery
Authors: Cecchini Stefano , Cavazzini Egildo , Marchesi Federico , Sarli Leopoldo , Roncoroni Luigi 
Published: December 2010

AbstractBackgroundAt present, the impact of obesity on short‐term outcomes of general surgery remains controversial, especially in the field of laparoscopy. Most studies on the subject have used the body mass index (BMI) to define obesity without distinguishing between visceral and subcutaneous storage. Computed tomography (CT) volumetric analysis permits accurate evaluation of site‐specific volume of adipose tissue. The purpose of this study was to compare CT volumetric fat parameters and the BMI for predicting short‐term outcomes of colon surgery.MethodsA retrospective analysis was conducted of 231 consecutive patients undergoing elective colon resection, with open or laparoscopic technique, from January 2007 to April 2009. CT volumetric quantification of abdominal visceral and subcutaneous adipose tissue was performed. Intraoperative and perioperative data were collected.ResultsA total of 187 patients were enrolled. BMI showed a direct correlation with fat volumetric parameters but not with the visceral/subcutaneous fat ratio. Operating time was correlated with subcutaneous fat storage and BMI in the laparoscopic right colectomy subgroup. No associations were found with the conversion rate. Length of the hospital stay was correlated with the visceral/subcutaneous fat ratio in the laparoscopic left colectomy subgroup. Whereas the overall postoperative complication rate and mortality were not associated with fat parameters, the postoperative surgical complication rate was associated with visceral volumetric parameters in the laparoscopic left colectomy subgroup.ConclusionsShort‐term outcomes of colon surgery are better predicted by fat volumetric parameters than by the BMI. This study has provided new elements for discussion on the impact of visceral and subcutaneous adiposity in laparoscopic and traditional colon surgery.
Reference Accuracy in the General Surgery Literature
Authors: Awrey Julianne , Inaba Kenji , Barmparas Galinos , Recinos Gustavo , Teixeira Pedro G. R. , Chan Linda S. , Talving Peep , Demetriades Demetrios 
Published: December 2010

AbstractBackgroundReference inaccuracy in scientific articles brings the scientific validity of the research into question and may create difficulty when accessing the cited background data. The objective of this study was to examine the reference accuracy in the general surgery literature and its correlation with the journal impact factor.MethodsFive general surgery journals were chosen with varying impact factors. From the year 2007, one issue was randomly chosen from each journal, and from each issue 180 citations were randomly chosen for review. Three investigators evaluated the chosen references for primary, citational, and quotational errors. The impact factor of each journal was compared to the percentage of errors detected.ResultsThe total number of errors per journal ranged from 31.3 to 39.3%, with a total of 35.4% of all citations reviewed containing some type of error. The most common error type detected was incorrect citation of the primary source supporting a statement, the incidence of which ranged from 13.8 to 25.2%, depending on the journal, and accounting for 53.6% of the total errors found. Citational errors, which included incorrect author names, pagination, dates, and issue and volume numbers, ranged from 1.8 to 18.1% and accounted for 20.4% of the total errors detected. Qualitative errors, which occurred when the author misquoted another author’s written assertions or conclusions, ranged from 7.4 to 16.0% and accounted for 34.7% of the total errors detected. Quantitative errors (misquoted numerical data) ranged from 3.1 to 8.6% and accounted for 17.9% of the total errors detected. No association between impact factor and error rate was demonstrated.ConclusionsReference inaccuracy is common in the general surgery literature. The impact factor has no clear association with the error rate, demonstrating that journal quality does not necessarily correlate with reference quality. Further investigation into potential methods for improving reference accuracy in the general surgery literature is warranted.
Single port laparoscopic cholecystectomy: which technique, which surgeon, for which patient? A study of the implementation in a teaching hospital
Authors: Mutter D. , Callari C. , Diana M. , Dallemagne B. , Leroy J. , Marescaux J. 
Published: December 2010

AbstractBackgroundSingle port cholecystectomy is increasingly performed. This procedure can be challenging, and we lack factors predicting the operative difficulty.AimsTo assess the role of surgeon experience and identify possible predictive factors of intraoperative difficulties.Patients and methodsSixty‐one selected patients were prospectively enrolled between January 2008 and August 2010. Six surgeons were involved (3 seniors, 3 juniors).Anthropometrics of the patients, types of ports, exposure methods and intraoperative data were recorded. Pain was assessed with the visual analogic scale at postoperative day 1 (POD 1 VAS).ResultsFifty‐eight patients with symptomatic gallstones and three with acute cholecystitis underwent single port cholecystectomy. The mean BMI, weight and height were 25.7 kg/m2 (SD 4.45), 71.8 kg (SD 14.83) and 166 cm SD 0.07, respectively. Mean operative time was 68.4 min (SD 26.98). Anthropometrics had no influence on operative time. Senior surgeons performed more rapidly, but the difference was not significant. The overall mean POD 1 VAS was 2.26, (SD 1.81). The mean hospital stay was 2.22 days, (SD 0.9). No complications occurred. An additional exposure method was necessary in 19 procedures. This cluster presented a significantly higher operating time (81.5 min, SD 31.69 vs. 62.7, SD 22.74;p = 0.01) and POD 1 VAS (1.92 vs. 3;p = 0.031).ConclusionSingle trocar cholecystectomy can be implemented safely in teaching hospitals. Anthropometrics are not predictive of operative difficulties. The need for additional exposure systems affects the operative time and pain negatively, reflecting greater technical difficulties. Research to optimize instruments may help to solve these problems.
Surface Properties and Micellar Molecular Interaction in Binary Systems of a Biosurfactant Sodium Deoxycholate (NaDC) with Conventional Surfactants
Authors: Wang Zhongni , Wu Tonghao , Zhou Wu , Wei Xilian , Zhao Jing 
Published: December 2010

AbstractSurface tension for the binary mixtures of a biosurfactant sodium deoxycholate (NaDC) with three different conventional surfactants (p‐(1,1,3,3‐tetramethylbutyl)phenol polyoxyethylene, polyoxethylene‐10‐oleyl ether, and sodium oleate) were measured in buffer solutions at different temperatures. Surface properties were determined as well as the micellar characteristics like composition, micellar molecular interaction parameter (β), activity coefficients (f1, f2), and the free energy of micellization were analyzed using some theoretical models, including Clint, Rubingh, Motomura and Maeda models. The results reveal that all the three investigated systems show non‐ideality in the micelle formation by the deviation in the experimental critical micelle concentration (CMC), f1, f2, and negative β values from the ideal values. The proportion of NaDC in the mixed micelle (X1) calculated by all models increases with increasing the molar fraction of NaDC in solution (αNaDC), but the X1 values are very small even at the high αNaDC. Moreover, by using the Maeda theory, the results suggest the chain‐chain interaction among surfactants does not seem to be strong. It is noted that two break points were observed in the surface tension plots of pure NaOL and NaDC/NaOL mixture solutions. Interestingly, by introducing moderate NaDC or decreasing the temperature, the first break point disappeared for the two systems.
The Health Promoting Properties of the Conjugated Isomers of α‐Linolenic Acid
Authors: Hennessy Alan A. , Ross R. Paul , Devery Rosaleen , Stanton Catherine 
Published: December 2010

AbstractThe bioactive properties of the conjugated linoleic acid (CLA) isomers have long been recognised and are the subject of a number of excellent reviews. However, despite this prominence the CLA isomers are not the only group of naturally occurring dietary conjugated fatty acids which have shown potent bioactivity. In a large number of in vitro and in vivo studies, conjugated α‐linolenic acid (CLNA) isomers have displayed potent anti‐inflammatory, immunomodulatory, anti‐obese and anti‐carcinogenic activity, along with the ability to improve biomarkers of cardio‐vascular health. CLNA isomers are naturally present in high concentrations in a large variety of seed oils but can also be produced in vitro by strains of lactobacilli and bifidobactena through the activity of the enzyme linoleic acid isomerase on α‐linolenic acid. In this review, we will address the possible therapeutic roles that CLNA may play in a number of conditions afflicting Western society and the mechanisms through which this activity is mediated.
Dynamic Analysis of Phorbol Esters in the Manufacturing Process of Fatty Acid Methyl Esters from Jatropha curcas Seed Oil
Authors: Ichihashi Kosuke , Yuki Dai , Kurokawa Hiroshi , Igarashi Akinori , Yajima Toshio , Fujiwara Masami , Maeno Katsuhiro , Sekiguchi Shizuo , Iwata Mitsuo , Nishino Hoyoku 
Published: December 2010

AbstractJatropha curcas seed oil, which is unsuitable as an edible oil but has received attention as a novel vegetable fat and oil resource, contains tumor‐promoting phorbol esters. Currently, six types of derivatives of 12‐deoxy‐16‐hydroxyphorbol (DHPEs) in J. curcas oil have been identified, and their toxicological safety for humans is being discussed. However, it is reported that most DHPEs disappear during the transesterification process. We investigated the dynamics of phorbol esters in the manufacturing process of fatty acid methyl esters from J. curcas seed oil. With the assumption that the precursor ion was the fragment ion (m/z = 311) from the frame unit of phorbol esters and their derivatives, we developed an LC–MS method for detecting the product ion (m/z = 165), which was obtained by cleavage of the fragment ion. The derivatives generated from the structural changes of the phorbol esters existed in fractions of glycerine–water in the manufacturing process; however, phorbol esters and their derivatives were not detected in the fatty acid methyl esters that were produced via a high‐vacuum distillation process. Investigation into the dynamics of phorbol esters confirmed that the contents of phorbol esters, including DHPEs, in the fatty acid methyl esters were under detection limits.
A new pelvic rod system for the surgical correction and fixation of pelvic obliquity in pediatric neuromuscular scoliosis
Authors: Chechik Ofir , Fishkin Michael , Wientroub Shlomo , Ovadia Dror 
Published: December 2010

Purpose To describe surgical outcomes using the new device in pediatric neuromuscular scoliosis. Methods All patients with neuromuscular disorders requiring surgery with pelvic fixation for the correction of scoliosis in the period 2002–2009 were operated by the new pelvic rod fixation device. Coronal and sagittal alignment before and after surgery until the latest follow-up were evaluated by standard X-rays. Intraoperative and postoperative complications were recorded. Results All 18 study patients (mean age at surgery 15 years, range 10–27) achieved solid fusion at a mean follow-up of 41 months. The coronal Cobb angle improved from 82° ± 31° (range 36–168) to 33° ± 25° at the last follow-up (range 9–95 months) ( P < 0.0001). Pelvic obliquity improved from 19° ± 6° (range 10–30) to 5° ± 5° (range 0–14) ( P < 0.0001). Early complications included pneumonia, urinary tract infection, disseminated intravascular coagulation (DIC), and hypovolemic shock. Three patients required debriding and received prolonged antimicrobial therapy for deep wound infection (none required implant removal). At the latest follow-up, no patient complained of lumbar pain or worsening of ambulatory status or level of activity. Conclusion Surgery employing the new pelvic rod fixation device allowed solid fusion and fixation with significant correction of multiplanar deformity, but the complication rate was high.
Death investigation systems and disease surveillance
Authors: McGOWAN C. R. , VIENS A. M. 
Published: December 2010

SUMMARYMedico-legal death investigation systems have the potential to play an important role in disease surveillance. While these systems are in place to serve a public function, the degree to which they are independent of central government can vary depending on jurisdiction. How these systems use this independence may present problems for public health initiatives, as it allows death investigators to decline to participate in government-led surveillance regardless of how critical the studies may be to public health and safety. A recent illustration of this problem in the UK is examined, as well as general lessons for removing impediments to death investigation systems participating in public health research.
Large offset monochromators at PETRA III
Authors: Horbach J. , Degenhardt M. , Hahn U. , Heuer J. , Peters H. B. , Schulte-Schrepping H. , Donat A. , Lüdecke H. 
Published: December 2010

For the beamlines of the new synchrotron radiation source PETRA III, fixed-exit double crystal monochromators with specific features were developed. To achieve a compact arrangement of the canted undulator beamlines at Sectors 2, 4 and 6, it is necessary to shift one of the two beamlines in vertical direction. This is done by so-called large offset monochromators. Two of these monochromators (LOM500 and Mono-P06) accept the white beam and are therefore cooled with liquid nitrogen. The third one accepts a monochromatic beam and has no cooling system. The challenge with this device (LOM1250) is the large offset of the beam by 1.25 m. The energy range in combination with the large vertical beam offset demands for a relative crystal movement of roughly 3 m along the beam direction. This is implemented by translating each crystal by up to 1.5 m. It is equipped with a visible laser-based stabilization which allows compensating thermal drift of the mechanical components involved in the positioning of the crystals. With this novel approach the X-ray beam is not attenuated by beam position monitors.
Constraint-Guided Workflow Composition Based on the EDAM Ontology
Authors: Lamprecht Anna-Lena , Naujokat Stefan , Steffen Bernhard , Margaria Tiziana 
Published: December 2010

AbstractMethods for the automatic composition of services into executable workflows need detailed knowledge about the application domain, in particular about the available services and their behavior in terms of input/output data descriptions. In this paper we discuss how the EMBRACE data and methods ontology (EDAM) can be used as background knowledge for the composition of bioinformatics workflows. We show by means of a small example domain that the EDAM knowledge facilitates finding possible workflows, but that additional knowledge is required to guide the search towards actually adequate solutions. We illustrate how the ability to flexibly formulate domain-specific and problem-specific constraints supports the workflow development process.
Alignment-free estimation of nucleotide diversity
Authors: Haubold Bernhard , Reed Floyd A. , Pfaffelhuber Peter 
Published: December 2010

Abstract
Motivation: Sequencing capacity is currently growing more rapidly than CPU speed, leading to an analysis bottleneck in many genome projects. Alignment-free sequence analysis methods tend to be more efficient than their alignment-based counterparts. They may, therefore, be important in the long run for keeping sequence analysis abreast with sequencing.
Results: We derive and implement an alignment-free estimator of the number of pairwise mismatches, . Our implementation of , pim, is based on an enhanced suffix array and inherits the superior time and memory efficiency of this data structure. Simulations demonstrate that is accurate if mutations are distributed randomly along the chromosome. While real data often deviates from this ideal, remains useful for identifying regions of low genetic diversity using a sliding window approach. We demonstrate this by applying it to the complete genomes of 37 strains of Drosophila melanogaster, and to the genomes of two closely related Drosophila species, D.simulans and D.sechellia. In both cases, we detect the diversity minimum and discuss its biological implications.
Availability: pim is written in standard C and its sources can be downloaded from http://guanine.evolbio.mpg.de/pim/.
Contact: haubold@evolbio.mpg.de
Supplementary information: Supplementary data are available at Bioinformatics online.
Evaluation of chimerism by quantitative PCR analysis of DNA polymorphism after allogeneic hematopoietic stem cell transplantation in a pediatric population with malignancies
Authors: Bautista F. , Moreno L. , Fernández‐Navarro J. M. , Senent L. , Andrés M. M. , Castel V. , Verdeguer A. 
Published: December 2010

Bautista F, Moreno L, Fernández‐Navarro JM, Senent L, Andrés MM, Castel V, Verdeguer A. Evaluation of chimerism by quantitative PCR analysis of DNA polymorphism after allogeneic hematopoietic stem cell transplantation in a pediatric population with malignancies. Pediatr Transplantation 2011: 15:81–87. © 2010 John Wiley & Sons A/S.Abstract:  Relapse remains the major pitfall to success for Allo‐HSCT in children with malignancies. Ninety‐one patients undergoing Allo‐HSCT were retrospectively reviewed. Chimerism status was evaluated at days +30, +60, and +100 in PB. VNTR‐PCR and STR‐PCR were used for this purpose. Thirty‐one patients recurred (34%) and none survived. Thirty‐two remain alive in CR (35%). Patients who achieved a CC at those days had a significant higher RFS and OS than patients who did not. Twelve patients showing PMC had an increased risk of recurrence (p = 0.02. OR 7.7). In the univariate analysis, the probability of death was higher in patients who were not in first CR before transplant (p = 0.008.OR 2.09) and in those receiving cells not from PB (p = 0.002.OR 2.03). In the multivariate analysis, the absence of CC at day +100 was associated with a higher probability of relapse (p = 0.004. OR 10.8) and death (p = 0.016. OR 9.3). Serial chimerism PCR‐based analyses of polymorphic DNA markers can predict relapse. Patients with PMC are at the highest risk of recurrence. Patients receiving an Allo‐HSCT in first CR from PB who achieve a CC at day +100 have a better outcome.