bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pharmacologic manipulation of random skin flaps with pentoxifylline
Authors: Hayden Richard E. , Snyder Brad J. 
Published: October 2009

AbstractThe literature demonstrates inconsistent results amongst investigators who have used pentoxifylline in an effort to enhance skin flap survival. This study employed a standardized skin flap model in the rat and a standard intraperitoneal dose of pentoxifylline (10 mg/kg) delivered in four different temporal regimens. Fluorescein staining and length of flap survival were measured. The only regimen that demonstrated increased flap survival over saline controls included administration of the drug immediately upon raising the flap and every 12 hours for the next 7 days. Three different regimens that included preoperative administration of the drug failed to demonstrate a beneficial effect on skin flap survival. Slight improvement in flap survival was seen in animals receiving fluorescein. These results suggest an inconsistent pentoxifylline effect even within a single controlled study.
Biochemical aspects of autologous fibrin glue derived from ammonium sulfate precipitation
Authors: Park Moon Suh , Cha Chang 
Published: October 2009

AbstractThe autologous fibrin glue (AFG) was produced from 30 human donors using the ammonium sulfate precipitation method, and a study of its biochemical composition was performed. The fibrinogen concentration ranged 13 to 57 mg/mL, the yield averaged 54.6%, and there was a direct relationship between the level of fibrinogen in plasma and AFG which had been made from the same donor's plasma. Our results suggest that the quality of this category of AFG depends partially on the fibrinogen level of donor's plasma. Quality control of the AFG is discussed. Additionally, the effectiveness of three fibrynolysis inhibitors were compared to find an optimum one which inhibits autofibrinolysis of this glue. Tranexamic acid and epsilon aminocaproic acid (EACA) were acceptable alternatives to aprotinin.
Polymerase chain reaction (PCR) identification of human papillomavirus (HPV) DNA in verrucous carcinoma of the larynx
Authors: Kasperbauer Jan L. , O'Halloran Gerard L. , Espy Mark J. , Smith Thomas F. , Lewis Jean E. 
Published: October 2009

AbstractThe incidence of human papillomavirus (HPV) DNA in archival formalin‐fixed, paraffin‐embedded tissue sections from verrucous carcinoma of the larynx was determined using polymerase chain reaction (PCR) with consensus primers and by in situ hybridization designed to detect HPV types 6/11, 16/18, 31/33/35. HPV DNA was detected in 17 (85%) of 20 tissue samples by PCR; none of the 20 samples were positive for the seven genotype types tested by in situ hybridization. PCR is a valuable tool to detect HPV and therefore will significantly clarify the importance of HPV in squamous mucosal disorders.
Recurrent respiratory papillomatosis: Juvenile versus adult forms
Authors: Doyle Deborah J. , Gianoli Gerard J. , Espinola Trina , Miller Robert H. 
Published: October 2009

AbstractRecurrent respiratory papillomatosis (RRP) has been described to have a juvenile or aggressive form and an adult or less aggressive form. However, the aggressive form may occur in an adult and vice versa. Some authors have reported a quiescence in the juvenile form with the onset of puberty. In order to further characterize these two forms of RRP and to analyze the effects of puberty, we reviewed the records of 32 patients treated for RRP at our institution over a 10‐year period. We found that the aggressive form typically occurs in the very youngest of patients (average of 2 years old as compared to an average of 17 years old in the less aggressive form). Although subglottic involvement universally occurred in our group with aggressive disease, approximately 40% developed subglottic disease very early as compared with 20% of patients with less aggressive disease. Additionally, our data do not support the theory of spontaneous regression with the onset of puberty. These and other findings will be discussed in detail. We also propose a new classification for RRP to eliminate confusion.
Prevalence of carotid canal dehiscence in the human middle ear: A report of 1000 temporal bones
Authors: Moreano Edwin H. , Paparella Michael M. , Zelterman Daniel , Goycoolea Marcos V. 
Published: October 2009

AbstractA total of 1000 human temporal bones were used to study the prevalence of carotid canal dehiscence, microdehiscence, and thin bony coverage. Additionally, this study compares the prevalence according to sex and temporal bone age. A carotid canal dehiscence was detected in 77 (7.7%) bones. It was present bilaterally in 23.2% of the paired temporal bones. The prevalence of carotid canal dehiscence decreases with increasing temporal bone age. It was found in 10 (15.9%) bones in the younger than 2 age group, as opposed to 43 (6.3%) bones from the 40 and older group.The concept of microdehiscence of the carotid canal is introduced. A carotid canal microdehiscence was found in 74 (7.4%) bones. Microdehiscences were noted to occur bilaterally in 12.3% of the paired bones. The prevalence of carotid canal microdehiscence also decreases with increasing temporal bone age. It was detected in 7 (11.1%) bones in the younger than 2 age group, in contrast to 51 (7.5%) bones in the 40 and older group.A total of 134 (15.5%) temporal bones were found to have a thin bony coverage, without the presence of a dehiscence or microdehiscence. The prevalence of thin coverage was noted to increase linearly with age. A thin carotid canal was found in 2 (8.3%) bones from the younger than 2 age group, whereas 113 (17.3%) temporal bones from the 40 and older group exhibited this entity.To the best of our knowledge, this is the first systematic study of histologic sections of a large number of temporal bones that looks at these entities.
Effects of odorants and irritants on respiratory behavior
Authors: Warren Donald W. , Walker James C. , Drake Amelia F. , Lutz Richard W. 
Published: October 2009

AbstractA technique that combines psychophysical measurements with continuous recording of nasal patency and respiratory behavior was used to study the psychophysical and respiratory responses of 10 subjects to well‐controlled stimulation with three compounds differing in relative stimulatory effectiveness for nasal olfactory and trigeminal chemoreceptors. All four concentrations of acetic acid, amyl acetate, and phenethyl alcohol were well above the odor detection threshold. The magnitudes of both the increase in odor strength and nasal irritation and the decreases in tidal volume were greatest for acetic acid and least for phenethyl alcohol. Among the odorants, differences in nasal irritation were greater than those in odor strength, and tidal volume appeared to have a reasonably close and inverse relationship to nasal irritation.
Charakterisierung des Ermüdungsverhaltens hochbeanspruchter Eisenbahnvollräder für den Hochgeschwindigkeitspersonenverkehr bei betriebsrelevanten Temperaturen
Authors: Peters C. J. , Kerscher E. 
Published: October 2009

AbstractIm Hochgeschwindigkeitspersonenverkehr treten bei Eisenbahnrädern aufgrund von Brems‐ und Schlupfvorgängen Temperaturerhöhungen auf, die das Ermüdungsverhalten der Radstähle stark beeinflussen. Für eine zuverlässige Auslegung hochbeanspruchter Eisenbahnvollräder sind daher fundierte Kenntnisse des Ermüdungsverhaltens der eingesetzten Radwerkstoffe unter besonderer Berücksichtung betriebsrelevanter Temperaturen unabdingbar.In der vorliegenden Arbeit wurden die Vollradstähle R7 und R8 untersucht, die als Originalbauteile für den Hochgeschwindigkeitspersonenverkehr in technisch relevanten Wärmebehandlungszuständen zur Verfügung standen. Neben mechanischen Spannung‐Dehnung‐Hysteresismessungen wurden thermometrische und resistometrische Messverfahren gleichermaßen zur Beschreibung und Bewertung des Wechselverformungsverhaltens und der zugrundeliegenden Ermüdungsprozesse angewandt. Das Wechselverformungsverhalten wird auf Basis der ortsabhängigen Mikrostruktur der Radwerkstoffe und dem daraus resultierenden ortsabhängigen Ermüdungsverhalten beurteilt.
NSAID switching and short‐term gastrointestinal outcome rates after the withdrawal of rofecoxib
Authors: Schneeweiss Sebastian , Glynn Robert J. , Avorn Jerry , Mamdani Muhammad , Mogun Helen , Solomon Daniel H. 
Published: October 2009

AbstractObjectiveThe consequences of the rofecoxib withdrawal on upper GI toxicity are largely unknown. We sought to estimate the effect of switching from selective Cox‐2 inhibitors to non‐selective non‐steroidal anti‐inflammatory drugs (nsNSAIDs) on the incidence of upper GI adverse events following the withdrawal of rofecoxib on 30 September 2004.MethodsWe identified a cohort of 33 045 patients with arthritis and chronic use of any selective Cox‐2 inhibitor during the 6 months before the withdrawal of rofecoxib in claims data from several US health plans. We calculated monthly rates of hospitalization for upper GI adverse events or upper GI endoscopy for the 6 months before and 3 months after the switching and compared the time trends in outcomes.ResultsIn the subgroup of 15 916 patients using rofecoxib immediately before its withdrawal, 2626 (17%) switched to nsNSAIDs without co‐prescribing of a gastroprotective drug, 146 (1%) with a gastroprotective drug, and 5246 (33%) switched to either celecoxib or valdecoxib. Among those switching to nsNSAID without gastroprotection, time trends of upper GI hospitalization rates and endoscopies did not significantly increase compared with those switching to celecoxib or valdecoxib (+0.3 per 1000 per month; 95%CI −3.0 to 3.5). The visit rate for peptic ulcer disease (PUD) increased more in the group switching to nsNSAIDs without gastroprotection (+5.2 visits per 1000 per month; 1.2–9.2) compared with the group switching to another coxib.ConclusionsShort‐term follow‐up data suggest that the sudden shift from rofecoxib to nsNSAIDs without gastroprotection did not increase the rate of hospitalization for GI complications but increased outpatient visits for PUD. Copyright © 2009 John Wiley & Sons, Ltd.
An interdomain disulfide bridge links the NtA and first FS domain in agrin
Authors: McFarlane Ainsley A. , Stetefeld Jörg 
Published: October 2009

AbstractAgrin is a multidomain heparan sulfate proteoglycan involved in postsynaptic differentiation at the neuromuscular junction. Binding of agrin to synaptic basal lamina is mediated by the N‐terminal agrin (NtA) domain. The NtA domain of agrin is followed by a tandem of nine follistatin‐like (FS) domains forming a rod‐like spacer to the laminin G‐like domains of the molecule. Here we report that the most C‐terminal cysteine residue of NtA (Cys123) forms an interdomain disulfide bond with the FOLN subdomain of the FS module. Remarkably, this single cysteine is flanked by Leu117 and Val124, which are two essential β‐branched amino acids forming the heterocomplex of NtA with the γ1 chain of laminin. Moreover, we show that this covalent linkage compensates for the seven amino acid residue splice insert at the very C‐terminal helix H3 and causes a rigid interface between NtA and FS independent of the alternative mRNA splice event. These results suggest that the interdomain disulfide bond between the NtA and the first FS domain might be important for the proper folding of agrin.
Process hazard analysis quality
Authors: Collins Robert L. 
Published: October 2009

AbstractIn this article, the author will discuss the elements that go into a high quality process hazard analysis (PHA). Specific suggestions for performing a high quality PHA will be presented and discussed. The author will show that it is possible to adhere faithfully to the legal requirements in performing a PHA and still produce a poor quality PHA. It is only through continued focus on the basic principle underlying the performance of a PHA (i.e., the prevention of potential future incidents) in every aspect of the PHA's performance that a high quality PHA will result. When management realizes that they can expend valuable resources in the effort to perform either a poor quality PHA (i.e., just what the law requires) or a high quality PHA, the author is confident that focus will shift to a demand for high quality performance. In this article, we will discuss the elements that go into the performance of a PHA. It is through a better understanding of the application of these elements that PHA team leaders can infer the existence of a high quality PHA. © 2009 American Institute of Chemical Engineers Process Saf Prog, 2010
Microstructural, thermal, and conducting properties of Bi4−xPbxV2O11−δ (0 ≤ x ≤ 0.4) compound as solid electrolyte
Authors: Kant R. , Singh K. , Pandey O. P. 
Published: October 2009

AbstractThe effects of doping were investigated with respect to concentration of dopant and sintering temperature. The compound is prepared by a solid‐state reaction route sintered in the temperature range from 750 to 825 °C. X‐ray diffraction study reveals the existence of α‐phase of Bi4−xPbxV2O11−δ compound for all compositions of 0.1 ≤ x ≤ 0.4. However, the formation of solid solution was observed up to x = 0.2. The higher conductivity obtained for x = 0.2 composition of the sample also supports this finding. The scanning electron microscopy study of the samples sintered at various temperatures was done to correlate the effect of sintering temperature on microstructure and ionic conductivity.
Electrodeposition of Bi2Te3 films and micro‐pillar arrays on p‐Si(100) wafers
Authors: Liu Da‐Wei , Xu Ying , Li Jing‐Feng 
Published: October 2009

AbstractBi2Te3 films and micro‐pillar arrays were electrodeposited, respectively, onto p‐Si(100) wafers and into micro‐templates that were etched on the same wafers with reactive ion etching (RIE). With the potentials of −100 to −300 mV (vs. saturated calomel electrode), Bi2Te3 films can be obtained from Bi3+ and HTeO solution, which showed a (001) preferential orientation. Micro‐templates with vertical holes of 15–18 µm in diameter and 40 µm in depth were etched on p‐Si(100) wafers, and then were set as cathodes. During electrodeposition, the SiO2 layer on the wafer surface served as an insulating layer, and Bi2Te3 only crystallized on the inner wall of etched holes. With the potentials of −300 to −700 mV, Bi2Te3 pillar arrays can be fabricated by filling electrodeposition, and the filling ratios and qualities were sensitive to the potentials. After removing the templates with RIE, the Bi2Te3 pillars can stand on the wafer surfaces.
Rapid simultaneous quantitative determination of different small pharmaceutical drugs using a conventional matrix‐assisted laser desorption/ionization time‐of‐flight mass spectrometry system
Authors: Persike Markus , Karas Michael 
Published: October 2009

AbstractThe present study establishes a simple, rapid and sensitive method for the simultaneous quantification of different small pharmaceutical drugs using a matrix‐assisted laser desorption/ionization source (MALDI) coupled with a time‐of‐flight (TOF) mass analyzer. Neither time‐consuming sample preparation, nor special target plates, isotopically labelled internal standards or other extra equipment are necessary. A simple standard dried‐droplet preparation with the common matrix α‐cyano‐4‐hydroxycinnamic acid (CHCA) was used. The background signals of CHCA in the low‐mass region did not pose the presumed problem, because the sensitivity, resolution and mass accuracy of a modern MALDI‐TOF MS system is sufficient to overcome this difficulty.Four experiments were performed in order to verify the quantification method. First, ten different phenothiazines were quantified in the range of 5–2000 nM (1–880 ng/mL). A good precision (relative standard deviation (RSD) 4.4–9.3%), linearity (R2 >0.99) and accuracy (error 4.7–11%) was obtained in all cases. Additionally, simultaneous quantification of these ten phenothiazines was carried out in human plasma without prior chromatographic separation in the range of 2–1750 ng/mL yielding good linearity, precision and accuracy (mean RSD 7.6%; R2 >0.99, mean error 8.0%). Accordingly, a quantitative analysis of ten chemically and pharmaceutically unrelated drugs was performed in the same way. A comparable linearity (R2 >0.99), precision (mean RSD 7.6%) and accuracy (mean error 8.3%) was obtained in the range of 5–2000 nM. Finally, the prazosin content of a commercial tablet was directly determined without further purification steps. Copyright © 2009 John Wiley & Sons, Ltd.
Effect of Surface Properties on Nanoparticle–Cell Interactions
Authors: Verma Ayush , Stellacci Francesco 
Published: October 2009

AbstractThe interaction of nanomaterials with cells and lipid bilayers is critical in many applications such as phototherapy, imaging, and drug/gene delivery. These applications require a firm control over nanoparticle–cell interactions, which are mainly dictated by surface properties of nanoparticles. This critical Review presents an understanding of how synthetic and natural chemical moieties on the nanoparticle surface (in addition to nanoparticle shape and size) impact their interaction with lipid bilayers and cells. Challenges for undertaking a systematic study to elucidate nanoparticle–cell interactions are also discussed.magnified image
The (re)marketing of disability in pop: Ian Curtis and Joy Division
Authors: WALTZ MITZI , JAMES MARTIN 
Published: October 2009

AbstractIn this article we examine the relatively new use of disability as a marketing device in pop music. Our analysis makes specific reference to how the career of Ian Curtis and Joy Division has become overshadowed by his epilepsy, depression and subsequent suicide, with comparison between early press and promotional materials from 1979–1980 and more recent materials created to promote reissues and films about Curtis. It also references other relevant individuals from the pop music sphere and marketing campaigns created around them that ignore or highlight issues of disability.Using these examples, we examine the ways in which messages about disability are packaged and presented within pop marketing discourses and discuss the issue of ‘acceptable’ and ‘unacceptable’ disability identities in pop, which have been created through a largely marketing-driven discourse. Finally, we briefly explore how the deployment of ‘disabled’ identities impacts on the musicians so identified, as opposed to on the sales of products.
NAViGaTOR: Network Analysis, Visualization and Graphing Toronto
Authors: Brown Kevin R. , Otasek David , Ali Muhammad , McGuffin Michael J. , Xie Wing , Devani Baiju , Toch Ian Lawson van , Jurisica Igor 
Published: October 2009

Abstract
Summary: NAViGaTOR is a powerful graphing application for the 2D and 3D visualization of biological networks. NAViGaTOR includes a rich suite of visual mark-up tools for manual and automated annotation, fast and scalable layout algorithms and OpenGL hardware acceleration to facilitate the visualization of large graphs. Publication-quality images can be rendered through SVG graphics export. NAViGaTOR supports community-developed data formats (PSI-XML, BioPax and GML), is platform-independent and is extensible through a plug-in architecture.
Availability: NAViGaTOR is freely available to the research community from http://ophid.utoronto.ca/navigator/. Installers and documentation are provided for 32- and 64-bit Windows, Mac, Linux and Unix.
Contact: juris@ai.utoronto.ca
Supplementary information: Supplementary data are available at Bioinformatics online.
INTERSNP: genome-wide interaction analysis guided by a priori information
Authors: Herold Christine , Steffens Michael , Brockschmidt Felix F. , Baur Max P. , Becker Tim 
Published: October 2009

Abstract
Summary: Genome-wide association studies (GWAS) have lead to the identification of hundreds of genomic regions associated with complex diseases. Nevertheless, a large fraction of their heritability remains unexplained. Interaction between genetic variants is one of several putative explanations for the ‘case of missing heritability’ and, therefore, a compelling next analysis step. However, genome-wide interaction analysis (GWIA) of all pairs of SNPs from a standard marker panel is computationally unfeasible without massive parallelization. Furthermore, GWIA of all SNP triples is utopian. In order to overcome these computational constraints, we present a GWIA approach that selects combinations of SNPs for interaction analysis based on a priori information. Sources of information are statistical evidence (single marker association at a moderate level), genetic relevance (genomic location) and biologic relevance (SNP function class and pathway information). We introduce the software package INTERSNP that implements a logistic regression framework as well as log-linear models for joint analysis of multiple SNPs. Automatic handling of SNP annotation and pathways from the KEGG database is provided. In addition, Monte Carlo simulations to judge genome-wide significance are implemented. We introduce various meaningful GWIA strategies that can be conducted using INTERSNP. Typical examples are, for instance, the analysis of all pairs of non-synonymous SNPs, or, the analysis of all combinations of three SNPs that lie in a common pathway and that are among the top 50 000 single-marker results. We demonstrate the feasibility of these and other GWIA strategies by application to a GWAS dataset and discuss promising results.
Availability: The software is available at http://intersnp.meb.uni-bonn.de
Contact: herold@imbie.meb.uni-bonn.de; becker@imbie.meb.uni-bonn.de
GeneE: Gene and protein query expansion with disambiguation
Authors: Schuemie Martijn J. , Kang Ning , Hekkelman Maarten L. , Kors Jan A. 
Published: October 2009

Abstract
Summary: When referring to genes, authors often use synonyms instead of the official gene symbols. In order to accurately retrieve as many relevant documents as possible, we have developed GeneE, a web application that expands a gene query to include all known synonyms, and adds disambiguation information for ambiguous terms, before forwarding the query to either PubMed, Google or Jane. The query expansion algorithm is also available as a web service.
Availability: http://biosemantics.org/geneE
Contact: m.schuemie@erasmusmc.nl
Specific Domain Structures Control Abscisic Acid-, Salicylic Acid-, and Stress-Mediated SIZ1 Phenotypes
Authors: Cheong Mi Sun , Park Hyeong Cheol , Hong Mi Ju , Lee Jiyoung , Choi Wonkyun , Jin Jing Bo , Bohnert Hans J. , Lee Sang Yeol , Bressan Ray A. , Yun Dae-Jin 
Published: October 2009

AbstractSIZ1 (for yeast SAP and MIZ1) encodes the sole ortholog of mammalian PIAS (for protein inhibitor of activated STAT) and yeast SIZ SUMO (for small ubiquitin-related modifier) E3 ligases in Arabidopsis (Arabidopsis thaliana). Four conserved motifs in SIZ1 include SAP (for scaffold attachment factor A/B/acinus/PIAS domain), PINIT (for proline-isoleucine-asparagine-isoleucine-threonine), SP-RING (for SIZ/PIAS-RING), and SXS (for serine-X-serine, where X is any amino acid) motifs. SIZ1 contains, in addition, a PHD (for plant homeodomain) typical of plant PIAS proteins. We determined phenotypes of siz1-2 knockout mutants transformed with SIZ1 alleles carrying point mutations in the predicted domains. Domain SP-RING is required for SUMO conjugation activity and nuclear localization of SIZ1. Salicylic acid (SA) accumulation and SA-dependent phenotypes of siz1-2, such as diminished plant size, heightened innate immunity, and abscisic acid inhibition of cotyledon greening, as well as SA-independent basal thermotolerance were not complemented by the altered SP-RING allele of SIZ1. The SXS domain also controlled SA accumulation and was involved in greening and expansion of cotyledons of seedlings germinated in the presence of abscisic acid. Mutations of the PHD zinc finger domain and the PINIT motif affected in vivo SUMOylation. Expression of the PHD and/or PINIT domain mutant alleles of SIZ1 in siz1-2 promoted hypocotyl elongation in response to sugar and light. The various domains of SIZ1 make unique contributions to the plant's ability to cope with its environment.