bluuebunny/crossref_metadata_2025_split huggingface dataset:
On the coupling of intracellular K+ ${{\rm{K}}}^{+}$ to glycolytic oscillations in yeast
Authors: Olsen Lars F. , Lunding Anita 
Published: June 2024

AbstractWe have investigated the interplay between glycolytic oscillations and intracellular concentration in the yeast Saccharomyces cerevisiae. Intracellular concentration was measured using the fluorophore potassium‐binding benzofuranisophthalate (PBFI). We found that is an essential ion for the occurrence of glycolytic oscillations and that intracellular concentration oscillates synchronously with other variables such as nicotinamide adenine dinucleotide hydride (NADH), intracellular adenosine triphosphate (ATP), and mitochondrial membrane potential. We also investigated if glycolysis and intracellular concentration oscillate in a number of yeast strains with mutations in transporters in the plasma membrane, mitochondrial membrane and in the vacuolar membrane. Most of these strains are still capable of showing glycolytic oscillations, but two strains are not: (i) a strain with a deletion in the mitochondrial Mdm38p transporter and (ii) a strain with deletion of the late endosomal Nhx1p () transporter. In these two mutant strains intracellular concentration seems to be low, indicating that the two transporters may be involved in transport of into the cytosol. In the strain, Mdm38p oscillations in glycolysis could be restored by addition of the exchange ionophore nigericin. Furthermore, in two nonoscillating mutant strains with a defective V‐ATPase and deletion of the Arp1p protein the intracellular is relatively high, suggesting that the V‐ATPase is essential for transport of out of the cytosol and that the cytoskeleton may be involved in binding to reduce the concentration of free ion in the cytosol. Analyses of the time series of oscillations of NADH, ATP, mitochondrial membrane potential, and potassium concentration using data‐driven modeling corroborate the conjecture that ion is essential for the emergence of oscillations and support the experimental findings using mutant strains.
Multi-Higgs boson production with anomalous interactions at current and future proton colliders
Authors: Papaefstathiou Andreas , Tetlalmatzi-Xolocotzi Gilberto 
Published: June 2024

Abstract
We investigate multi-Higgs boson production at proton colliders, in a framework involving anomalous interactions, focusing on triple Higgs boson production. We consider modifications to the Higgs boson self-couplings, to the Yukawa interactions, as well as new contact interactions of Higgs bosons with either quarks or gluons. To this end, we have developed a MadGraph5_aMC@NLO loop model, publicly available at [1], designed to incorporate the relevant operators in the production of multiple Higgs bosons (and beyond). We have performed cross section fits at various energies over the anomalous interactions, and have derived constraints on the most relevant anomalous coefficients, through detailed phenomenological analyses at proton-proton collision energies of 13.6 TeV and 100 TeV, employing the 6 b-jet final state.
Robotics in place and the places of robotics: productive tensions across human geography and human–robot interaction
Authors: Lynch Casey R. , Manalo Bethany N. , Muñoz-Viso Àlex 
Published: June 2024

AbstractBringing human–robot interaction (HRI) into conversation with scholarship from human geography, this paper considers how socially interactive robots become important agents in the production of social space and explores the utility of core geographic concepts ofscaleandplaceto critically examine evolving robotic spatialities. The paper grounds this discussion through reflections on a collaborative, interdisciplinary research project studying the development and deployment of interactive museum tour-guiding robots on a North American university campus. The project is a collaboration among geographers, roboticists, a digital artist, and the directors/curators of two museums, and involves experimentation in the development of a tour-guiding robot with a “socially aware navigation system” alongside ongoing critical reflection into the socio-spatial context of human–robot interactions and their future possibilities. The paper reflects on the tensions between logics of control and contingency in robotic spatiality and argues that concepts of scale and place can help reflect on this tension in a productive way while calling attention to a broader range of stakeholders who should be included in robotic design and deployment.
A new industrially magnetic capsule MedRobot integrated with smart motion controller
Authors: Hua Dezheng , Liu Xinhua , Królczyk Grzegorz M. , Li Weihua , Andriukaitis Darius , Gołdasz Janusz , Li Zhixiong 
Published: June 2024

AbstractCapsule medical robots with unique application advantages have broad prospects for gastrointestinal detection, targeted drug delivery, medical assistance, and other fields. However, due to the complexity of the gastrointestinal environment and the limitations of the space magnetic field, robust motion control of capsule robots is still a challenge. Using a permanent magnet (NdFeB) as a space magnetic source, a capsule robot manipulation instrument with an integrated motion intelligent control approach is proposed in this work. First of all, a steering fixture controlling a permanent magnet is designed, and a manipulation instrument capable of five degrees of motion freedom is built with low cost and high accuracy. Furthermore, an integrated motion control approach, consisting of a primary motion subsystem and an auxiliary motion subsystem, is presented, where the motion route of the capsule robot is planned. A parallel optimization strategy is adopted to improve the traditional Gray Wolf Optimization Algorithm, the improved version of which is utilized to tune the parameters of controllers. Finally, some experiments of the designed capsule robot are carried out in different planes and slopes, as well as simulated stomach and real pig stomach, respectively. The results show that the motion characteristics are continuous and stable, and the average position error is 4.2 mm, which meets the application requirements.
Early posterior vault distraction osteogenesis changes the syndromic craniosynostosis treatment paradigm: long-term outcomes of a 23-year cohort study
Authors: Wu Meagan , Barnett Sarah L. , Massenburg Benjamin B. , Ng Jinggang J. , Romeo Dominic J. , Taylor Jesse A. , Bartlett Scott P. , Swanson Jordan W. 
Published: June 2024

Abstract
Background
Early surgical management of syndromic craniosynostosis varies widely between centers, with patients typically undergoing multiple intracranial procedures through childhood. This study evaluates the long-term impact of early posterior vault distraction osteogenesis (PVDO) versus conventional treatment paradigms on the number and timing of subsequent craniofacial procedures.

Methods
We retrospectively analyzed the longitudinal operative patterns of patients with syndromic craniosynostosis treated from 2000 to 2023 with greater than five years of follow-up. Outcomes of patients who underwent early PVDO and conventional vault reconstruction were compared.

Results
Fifty-five patients met the inclusion criteria (30 PVDO and 25 conventional). Age at initial vault surgery was similar between the PVDO and conventional cohorts (7.6 vs. 8.8 months), as were baseline craniometrics (p > 0.05). Multiple fronto-orbital advancement (FOA) procedures were performed in only 1/30 (3%) PVDO-treated patient versus 12/25 (48%) conventionally-treated patients (p < 0.001). Twelve (40%) PVDO-treated patients did not undergo FOA at all. Among patients with Apert and Crouzon syndromes, fewer PVDO-treated patients required FOA prior to midface surgery (33% vs. 92%, p = 0.004) or repeat FOA (6% vs. 50%, p = 0.005) compared to conventionally-treated patients. Among patients with Muenke and Saethre–Chotzen syndromes, a similar proportion of patients required FOA in the PVDO and conventional cohorts (91% vs. 100%, p = 0.353), though no PVDO-treated patients required repeat FOA (0% vs. 44%, p = 0.018).

Conclusions
Early PVDO is associated with a reduction in the high burden of both FOA and, critically, revisionary frontal procedures which are commonly seen in conventionally-treated patients with syndromic craniosynostosis.
Label-free electrochemical aptasensor for the detection of HepG2 hepatocellular carcinoma cells
Authors: Pusta Alexandra , Tertis Mihaela , Kezan Denisa , Bogdan Diana , Suciu Maria , Pană Ovidiu , Fizeșan Ionel , Graur Florin , Cristea Cecilia , Al-Hajjar Nadim 
Published: June 2024

AbstractHepatocellular carcinoma (HCC) is the most common liver malignancy and is characterized by increasing incidence and high mortality rates. Current methods for the screening and diagnosis of HCC exhibit inherent limitations, highlighting the ever-growing need for the development of new methods for the early diagnosis of HCC. The aim of this work was to develop a novel electrochemical aptasensor for the detection of HepG2 cells, a type of circulating tumor cells that can be used as biomarkers for the early detection of HCC. A carbon screen-printed electrode was functionalized with a composite suspension containing graphene oxide, chitosan, and polyaniline nanoparticles to increase the electrode surface and provide anchoring sites for the HepG2 cell-specific aptamer. The aptamer was immobilized on the surface of the functionalized electrode using multipulse amperometry, an innovative technique that significantly reduces the time required for aptamer immobilization. The innovative platform was successfully employed for the first time for the amplification-free detection of HepG2 cells in a linear range from 10 to 200,000 cells/mL, with a limit of detection of 10 cells/mL. The platform demonstrated high selectivity and stability and was successfully used for the detection of HepG2 cells in spiked human serum samples with excellent recoveries.
Graphical abstract
Computational analysis of air bubble-induced frictional drag reduction on ship hulls
Authors: Mohammadpour Javad , Salehi Fatemeh , Garaniya Vikram , Baalisampang Til , Arzaghi Ehsan , Roberts Ross , Cervella Gio , Newport Jason , Hughes Peter , Abbassi Rouzbeh 
Published: June 2024

AbstractAbout 60% of marine vessels’ power is consumed to overcome friction resistance between the hull and water. Air lubrication can effectively reduce this resistance and lower fuel consumption, and consequently emissions. This study aims to analyze the use of a gas-injected liquid lubrication system (GILLS) to reduce friction resistance in a real-world scenario. A 3D computational fluid dynamics model is adopted to analyse how a full-scale ship (the Sea Transport Solutions Designed Catamaran ROPAX ferry) with a length of 44.9 m and a width of 16.5 m is affected by its speed and draught. The computational model is based on a volume of fluid model using the k-ꞷ shear stress transport turbulence model. Results show that at a 1.5 m draught and 20 knots cruising speed, injecting 0.05 kg/s of compressed air into each GILLS unit reduces friction resistance by 10.45%. A hybrid model of natural air suction and force-compressed air shows a friction resistance reduction of 10.41%, which is a promising solution with less required external power. The proposed technique offers improved fuel efficiency and can help to meet environmental regulations without engine modifications.
Curriculum-based university course timetabling considering individual course of studies
Authors: Steiner Elmar , Pferschy Ulrich , Schaerf Andrea 
Published: June 2024

Abstract
We consider a complex university timetabling problem arising in a four-year study program of teacher education where every student has to choose two subjects. Since any combination of two subjects is feasible, the goal of designing a collision-free timetable for every student seems to be unreachable. However, the task becomes more tractable because parallel groups are offered for most courses, i.e. sectioning of students takes place. Difficulties arise from the individual progress of students who often follow neither the prescribed term of each course nor the prescribed ordering of courses. Under these and other conditions, an optimized timetable can be determined by a multi-stage process, adjusted to the estimated student numbers and their past achievements. Some of the features encountered in this planning task were also part of the well-known ITC-2019 timetabling competition, while others constitute new aspects. After moving main lectures into a regular time grid with minimal changes concerning the previously existing plan, the task of finding a timetable for all lectures with parallel groups is modeled as an integer linear program. At a later time, students with their actual demands are allocated a non-overlapping set of courses that is relevant and feasible for their individual study situation. Besides the maximization of allocated courses, a fairness criterion is also invoked at this stage. Since both optimization tasks are prone to infeasibility, we introduce features to resolve this issue in practice.
Rethinking the Roughness Height: An Improved Description of Temperature Profiles over Short Vegetation
Authors: Boekee Judith , van der Linden Steven J. A. , ten Veldhuis Marie-Claire , Verouden Iris E. A. , Nollen Paul J. , Dai Yi , Jongen Harro J. , van de Wiel Bas J. H. 
Published: June 2024

AbstractIn this study, we present an extension to the Monin–Obukov similarity theory (MOST) for the roughness sublayer (RSL) over short vegetation. We test our theory using temperature measurements from fiber optic cables in an array-shaped set-up. This provides a high vertical measurement resolution that enables us to measure the sharp temperature gradients near the surface. It is well-known that MOST is invalid in the RSL as the flow is distorted by roughness elements. However, to derive the surface temperature, it is common practice to extrapolate the logarithmic profiles down to the surface through the RSL. Instead of logarithmic behaviour defined by MOST near the surface, our observations show near-linear temperature profiles. This log-to-linear transition is described over an aerodynamically smooth surface by the Van Driest equation in classical turbulence literature. Here we propose that the Van Driest equation can also be used to describe this transition over a rough surface, by replacing the viscous length scale with a surface length scale $$L_s$$

L
s

that represents the size of the smallest eddies near the grass structures. We show that $$L_s$$

L
s

scales with the geometry of the vegetation and that the model shows the potential to be scaled up to tall canopies. The adapted Van Driest model outperforms the roughness length concept in describing the temperature profiles near the surface and predicting the surface temperature.
Risk-reducing salpingectomy with delayed oophorectomy to prevent ovarian cancer in women with an increased inherited risk: insights into an alternative strategy
Authors: Gootzen TA , Steenbeek MP , van Bommel MHD , IntHout J , Kets CM , Hermens RPMG , de Hullu JA 
Published: June 2024

AbstractEpithelial ovarian cancer (EOC) is the most lethal type of gynaecological cancer, due to lack of effective screening possibilities and because the disease tends to metastasize before onset of symptoms. Women with an increased inherited risk for EOC are advised to undergo a risk-reducing salpingo-oophorectomy (RRSO), which decreases their EOC risk by 96% when performed within guideline ages. However, it also induces premature menopause, which has harmful consequences. There is compelling evidence that the majority of EOCs originate in the fallopian tube. Therefore, a risk-reducing salpingectomy with delayed oophorectomy (RRS with DO) has gained interest as an alternative strategy. Previous studies have shown that this alternative strategy has a positive effect on menopause-related quality of life and sexual health when compared to the standard RRSO. It is hypothesized that the alternative strategy is non-inferior to the standard RRSO with respect to oncological safety (EOC incidence). Three prospective studies are currently including patients to compare the safety and/or quality of life of the two distinct strategies. In this article we discuss the background, opportunities, and challenges of the current and alternative strategy.
Institutionalising a transdisciplinary curriculum: assemblages, territories, and refrains
Authors: Tsao Jack , Kochhar-Lindgren Gray , Lam Adrian Man Ho 
Published: June 2024

AbstractTransdisciplinary curricula and programmes in higher education have gained traction as universities respond to the supercomplexity of contemporary crises and an accelerated pace of change. However, institutionalising such a model within traditional disciplinary structures also poses a series of challenges. This study references the Common Core at The University of Hong Kong as an exemplar for the implementation of a sustainable transdisciplinary curriculum in higher education. Our analysis draws on Gilles Deleuze and Félix Guattari’s concepts of assemblages, territorialisation, and refrains in order to clarify the flexible, dynamic, and successful institutionalisation of a transdisciplinary curriculum. Key findings illustrate how the transdisciplinary assemblage is extended through relations regulated by discursive practices, connections with heterogenous participation from university stakeholders, modulating the flow of desires through funding and the inflections of disciplinary knowledge, and appropriating the rhythms and cycles of the broader institution. This framework for analysing institutionalisation endorses an adaptable model that draws in faculty, student, and administrative participation in a (non)human infrastructural platform for creative transdisciplinary education. These insights, in turn, provide a reference point for policymakers and university administrators interested in institutional and curricular transformation that is open to unpredictable future possibilities.
On Risk Evaluation and Control of Distributed Multi-agent Systems
Authors: Almen Aray , Dentcheva Darinka 
Published: June 2024

AbstractIn this paper, we deal with risk evaluation and risk-averse optimization of complex distributed systems with general risk functionals. We postulate a novel set of axioms for the functionals evaluating the total risk of the system. We derive a dual representation for the systemic risk measures and propose new ways to construct families of systemic risk measures using either a collection of linear scalarizations or non-linear risk aggregation. The proposed framework facilitates risk-averse sequential decision-making by distributed methods. The new approach is compared theoretically and numerically to other systemic risk measurements from the existing literature. We formulate a two-stage decision problem for a distributed system using a systemic measure of risk. The structure accommodates distributed systems arising in energy networks, robotics, and other practical situations. A distributed decomposition method for solving the two-stage problem is proposed and applied to a problem arising in communication networks. We have used this problem to compare the methods of systemic risk evaluation. We show that the risk evaluation via linear scalarizations of outcomes leads to less conservative risk evaluation and results in a substantially better solution to the problem at hand than aggregating the risk of individual agents.
Some Families of Random Fields Related to Multiparameter Lévy Processes
Authors: Iafrate Francesco , Ricciuti Costantino 
Published: June 2024

AbstractLet $${\mathbb {R}}^N_+= [0,\infty )^N$$

R

+
N

=

[
0
,
∞
)

N

. We here make new contributions concerning a class of random fields $$(X_t)_{t\in {\mathbb {R}}^N_+}$$

(

X
t

)

t
∈

R

+
N

which are known as multiparameter Lévy processes. Related multiparameter semigroups of operators and their generators are represented as pseudo-differential operators. We also provide a Phillips formula concerning the composition of $$(X_t)_{t\in {\mathbb {R}}^N_+}$$

(

X
t

)

t
∈

R

+
N

by means of subordinator fields. We finally define the composition of $$(X_t)_{t\in {\mathbb {R}}^N_+}$$

(

X
t

)

t
∈

R

+
N

by means of the so-called inverse random fields, which gives rise to interesting long-range dependence properties. As a byproduct of our analysis, we present a model of anomalous diffusion in an anisotropic medium which extends the one treated in Beghin et al. (Stoch Proc Appl 130:6364–6387, 2020), by improving some of its shortcomings.
Thermal investigation of relaxations of interacting and non-interacting amorphous solid dispersions
Authors: Péter-Haraszti Anna , Záhonyi Petra , Farkas Attila , Csontos István , Nagy Zsombor Kristóf , Szabó Edina , den Mooter Guy Van , Marosi György 
Published: June 2024

AbstractIn the present research, thermal investigation of amorphous solid dispersions (ASDs) was performed in order to compare their relaxation transitions. Two different active pharmaceutical ingredients (APIs), namely naproxen (NAP) and spironolactone (SPIR), were used as model drugs and combined with polyvinylpyrrolidone vinyl acetate (PVPVA64) copolymer to form stable ASDs. The reason for the API selection was their different interacting potentials based on the presence (in the case of NAP) and the lack of H-bond donor group (in the case of SPIR). Determination of both Tg and sub-Tg transitions suggested that ASDs containing NAP and PVPVA64 are ‘interacting’ systems with respect to the H-bonding. Besides, temperature-dependent Raman spectroscopic experiments confirmed that the naphthalene ring of the NAP has a significant role in the sub-Tg relaxations. In contrast, SPIR-PVPVA64 systems proved to be ‘non-interacting’ ASDs according to the MDSC, TSDC, and Raman measurements. This study highlights that the combination of the results of different thermoanalytical investigations with spectroscopic methods helps to understand the molecular background of the relaxations in ASDs and thus contributes to the conscious design of stable amorphous pharmaceuticals in the early stage of development.
Strengthening Recruitment and Retention: Mitigation Strategies in Two Longitudinal Studies of Pregnant Women in Pakistan
Authors: Yim Ilona S. , Ali Naureen Akber , Dosani Aliyah , Lalani Sharifa , Babar Neelofur , Nausheen Sidrah , Premji Shahirose Sadrudin ,   Maternal-infant Global Health Team (MiGHT) – Collaborators in Research
Published: June 2024

Abstract
Purpose
Global health researchers have a responsibility to conduct ethical research in a manner that is culturally respectful and safe. The purpose of this work is to describe our experiences with recruitment and retention in Pakistan, a low-middle-income country.

Description
We draw on two studies with a combined sample of 2161 low-risk pregnant women who participated in a pilot (n = 300) and a larger (n = 1861) prospective study of psychological distress and preterm birth at one of four centers (Garden, Hyderabad, Kharadar, Karimabad) of the Aga Khan University Hospital in Karachi, Pakistan.

Assessment
Challenges we encountered include economic hardship and access to healthcare; women’s position in the family; safety concerns and time commitment; misconceptions and mistrust in the research process; and concerns related to blood draws. To mitigate these challenges, we developed culturally acceptable study incentives, involved family members in the decision-making process about study participation, partnered with participants’ obstetrician-gynecologists, accommodated off site study visits, combined research visits with regular prenatal care visits, and modified research participation related to blood draws for some women.

Conclusion
Implementation of these mitigation strategies improved recruitment and retention success, and we are confident that the solutions presented will support future scientists in addressing sociocultural challenges while embarking on collaborative research projects in Pakistan and other low-middle-income countries.