bluuebunny/crossref_metadata_2025_split huggingface dataset:
Limosilactobacillus reuteri 6475 and Prevention of Early Postmenopausal Bone Loss
Authors: Gregori Giulia , Pivodic Aldina , Magnusson Per , Johansson Lisa , Hjertonsson Ulrika , Brättemark Emma , Lorentzon Mattias 
Published: June 2024

ImportanceDaily supplementation with the probiotic Limosilactobacillus reuteri ATCC PTA 6475 (L reuteri) vs placebo has previously been demonstrated to reduce bone loss in an estrogen deficiency mice model and older women, although the magnitude of the effect was small. We hypothesized that long-term treatment with L reuteri could result in clinically relevant skeletal benefits in postmenopausal osteoporosis.ObjectiveTo evaluate whether daily supplementation with L reuteri vs placebo could reduce early postmenopausal bone loss and whether the effects remained or increased over time during 2 years of treatment.Design, Setting, and ParticipantsA double-blind, randomized, placebo-controlled clinical trial was conducted between December 4, 2019, and October 6, 2022, at a single center in Gothenburg, southwestern Sweden. Participants were recruited by online advertisements, and letters were sent to 10 062 women aged 50 to 60 years. Responding women (n = 752) underwent telephone screening, resulting in 292 women being invited to a screening visit. Of those who were screened, 239 women met all inclusion criteria and had no exclusion criteria.InterventionsCapsules with L reuteri in 2 doses, 5 × 108 (low dose) or 5 × 109 (high dose) colony-forming units, taken twice daily or placebo were administered. All capsules also included cholecalciferol, 200 IU.Main Outcomes and MeasuresThe primary outcome was the relative change in tibia total volumetric bone mineral density (vBMD) over 2 years. Secondary outcomes included relative change in areal BMD of the lumbar spine and total hip, bone turnover markers C-terminal telopeptide cross-links of collagen type I and type I procollagen intact N-terminal propeptide, as well as tibia trabecular bone volume fraction and cortical vBMD. Both intention-to-treat and per-protocol analyses were conducted.ResultsA total of 239 postmenopausal women (median age, 55 [IQR, 53-56] years) were included. Tibia vBMD (primary outcome), hip and spine vBMD, and tibia cortical area and BMD decreased significantly in all groups, with no group-to-group differences (percent change tibia vBMD high dose vs placebo least-squares means, −0.08 [95 CI, −0.85 to 0.69] and low dose vs placebo least-squares means, −0.22 [95% CI, −0.99 to 0.55]). There were no significant treatment effects on any other predefined outcomes. A prespecified sensitivity analysis found a significant interaction between body mass index (BMI) and treatment effect at 2 years. No significant adverse effects were observed.Conclusions and RelevanceIn this randomized clinical trial of 239 early postmenopausal women, supplementation with L reuteri had no effect on bone loss or bone turnover over 2 years. The observed interaction between BMI and treatment effect warrants further investigation.Trial RegistrationClinicalTrials.gov Identifier: NCT04169789
Patient Safety and Satisfaction With Fully Remote Management of Radiation Oncology Care
Authors: Cuaron John J. , McBride Sean , Chino Fumiko , Parikh Dhwani , Kollmeier Marisa , Pastrana Gerri , Wagner Keri , Tamas Andrew , Gomez Daniel 
Published: June 2024

ImportancePatients of Memorial Sloan Kettering Cancer Center in New York, New York, are now offered a choice of either in-person or remote telehealth visits for radiation oncology care. However, safety and satisfaction among patients receiving treatment with fully remote physician management is unclear.ObjectiveTo analyze patient safety and satisfaction, financial implications, and environmental consequences associated with fully remote management among a cohort of patients treated with radiotherapy.Design, Setting, and ParticipantsThis single-institution retrospective cohort study was performed at Memorial Sloan Kettering Cancer Center, with patients treated with radiation who opted for fully remote management between October 1, 2020, and October 31, 2022. Data on patient safety events were prospectively collected with an in-house quality improvement reporting system. Patient satisfaction surveys were distributed electronically before, during, and after treatment. Patient transportation costs and environmental consequences were estimated based on differences in travel distance. Data analysis was performed from March 14 through September 19, 2023.ExposureRadiotherapy with fully remote physician management.Main Outcomes and MeasuresSatisfaction rates among patients opting for fully remote management were analyzed via surveys administered electronically after visits with clinicians. Patient safety events, defined as staff-reported actual events and near misses that had the potential to affect patient care, were reviewed. Rates and types of safety events were analyzed and compared with patients treated by onsite clinicians. Distances between patient home zip codes and treatment site locations were compared with estimated cost savings and decreased emissions.ResultsThis study included 2817 patients who received radiation oncology care with fully remote physician management. The median age of patients was 65 (range, 9-99) years, and more than half were men (1467 [52.1%]). Of the 764 safety events reported, 763 (99.9%) did not reach patients or caused no harm to patients. Nearly all survey respondents (451 [97.6%]) rated patient satisfaction as good to very good across all domains. For treatment with fully remote physician management, out-of-pocket cost savings totaled $612 912.71 ($466.45 per patient) and decreased carbon dioxide emissions by 174 metric tons.Conclusions and RelevanceIn this study, radiation oncology care provided by fully remote clinicians was safe and feasible, with no serious patient events. High patient satisfaction, substantial cost savings, and decreased environmental consequences were observed. These findings support the continuation of a fully remote management option for select patients in the post–COVID-19 era.
What is the optimal isodose line for stereotactic radiotherapy for single brain metastases using HyperArc?
Authors: Sagawa Tomohiro , Ikawa Toshiki , Ohira Shingo , Kanayama Naoyuki , Ueda Yoshihiro , Inui Shoki , Miyazaki Masayoshi , Konishi Koji 
Published: June 2024

AbstractPurposeThe study aimed to investigate the optimal isodose line (IDL) in linear accelerator‐based stereotactic radiotherapy for single brain metastasis, using HyperArc. We compared the dosimetric parameters for target and normal brain tissue among six plans with different IDLs.MethodsThis study included 30 patients with single brain metastasis. We retrospectively generated six plans for each tumor with different IDLs (80%, 70%, 60%, 50%, 40%, and 33%) using HyperArc. All treatment plans were normalized to the prescription dose of 35 Gy in five fractions which was covered by 95% of the planning target volume (PTV), defined by adding a 1.0 mm margin to the gross tumor volume (GTV). The dosimetric parameters were compared among the six plans.ResultsFor GTV > 0.1 cm3, the ratio of brain–GTV volumes receiving 25 Gy to PTV (V25Gy/PTV) was significantly lower at IDL 40%–70% than at IDL 80% and 33% (p < 0.01, retrospectively). For GTV < 0.1 cm3, V25Gy/PTV decreased continuously as IDL decreased. The values of D99% and D80% for GTV increased with decreasing IDL. An IDL of 50% or less was required to achieve D99% of greater than 43 Gy and D80% of greater than 50 Gy. The mean values of D99% and D80% for IDL 50% were 44.3 and 51.9 Gy.ConclusionThe optimal IDL is 40%–50% for GTV > 0.1 cm3. These lower IDLs could increase D99% and D80% of GTV while lowering V25Gy of normal brain tissue, which may help reduce the risk of radiation necrosis and improve local control.
Activation of cGAS/STING Drives Inflammation and Cellular Senescence of Macrophages in Ovarian Endometrioma Induced by Endometriotic Cyst Fluid
Authors: Ye Wenting , Sun Yan , Cai Jing , Yin Jinwen , Liu Jing , Liu Yuhua , Zhang Shuanghao , Xia Siyu , Song Yali 
Published: June 2024

AbstractOvarian endometrioma (OE) is a common gynecological condition characterized by the formation of “chocolate cysts”. Recent research indicates that the cyst fluid acts as a “toxic environment” for the ovary and plays a significant role in the development of OE, with macrophages being pivotal. However, the specific molecular and cellular mechanisms of it are not fully understood. In this study, clinical samples are integrated, single‐cell sequencing, in vivo and in vitro experimental models to comprehensively investigate the effects of OE fluid on ovarian function and the mechanisms of it. Combined with bioinformatics analysis and experimental validation, the findings demonstrate that OE fluid can cause ovarian function decline, which associated with inflammatory response, and mitochondrial dysfunction and cellular senescence, while activating the cGAS/STING signaling pathway. As a STING inhibitor, H‐151 effectively alleviates ovarian dysfunction, inflammatory state and cell apoptosis induced by OE fluid. Furthermore, it is also discovered that H‐151 can inhibit OE fluid‐induced mitochondrial dysfunction and cellular senescence. These findings provide important theoretical and experimental foundations for further research and development of STING inhibitors as potential drugs for treating ovarian dysfunction.
Advancements in Metal‐Organic, Enzymatic, and Nanocomposite Platforms for Wireless Sensors of the Next Generation
Authors: Mohan Brij , Virender  , Gupta Rakesh Kumar , Pombeiro Armando J. L. , Solovev Alexander A. , Singh Gurjaspreet 
Published: June 2024

AbstractAdvanced wireless sensors, incorporating metal‐organic frameworks (MOFs), enzymatic systems, and nanocomposites, offer unparalleled solutions for monitoring analytes and human physiological signals. These cutting‐edge sensors, when used with external devices, enable real‐time monitoring of analytes and physicochemical processes within the human body, thereby enhancing the understanding of complex biological systems. This study presents advancements in sensor development, fabrication techniques, and user‐friendly protocols. The performance of these sensors is evaluated based on their selectivity, sensitivity, and detection limits. Moreover, this article explores limitations, challenges, and key strategies to enhance analyte recognition from onsite environmental and biological species, ensuring human point‐of‐care safety.
Unraveling Dual Mechanisms in Quasi‐Layered Bi2O2Se via Defect Modulation for High‐Performance Aqueous Zn‐Ion Batteries
Authors: Hsieh Yi‐Yen , Chuang Yu‐Chun , Tuan Hsing‐Yu 
Published: June 2024

AbstractDeveloping cathode materials for aqueous zinc‐ion batteries (ZIBs) that offer high capacity, rapid charge–discharge rates, and prolonged cycle life remains a significant challenge. This study explores the use of zipper‐type Bi2O2Se nanoplates modified by selenium vacancy (Vse) modulation, which reduces electron scattering, enhances carrier mobility in [Bi2O2] conducting channels, and decreases coulombic interactions within electrostatic layers. The introduction of Se vacancies facilitates electron transfer from the host to [Bi2O2] channels and reduces scattering in the [Bi2O2] framework, thus improving carrier mobility. These Se‐poor Bi2O2Se nanoplates demonstrate a greater affinity for zinc ions, reduced diffusion barriers, and faster transport kinetics, which enable more efficient Zn‐ion insertion, tripling the electrochemical capacity, improving rate capabilities, and extending cycling life. Enhancements such as reinforced structural integrity and expanded interlayer spaces support a dual Zn‐ion‐driven mechanism involving both insertion and conversion reactions, essential for superior electrochemical storage performance. The results include an impressive discharge/charge capacity of 380.3 mA h g−1 at 0.1 A g−1, a cycle life of up to 10 000 cycles at 5 A g−1, and a current tolerance exceeding 10 A g−1. This research highlights how nano‐ and defect engineering of Bi2O2Se can significantly enhance ionic conductivity, expedite electron transfer, and improve Zn‐ion diffusion.
A Thermo‐Responsive MOFs for X‐Ray Scintillator
Authors: Li Hongjun , Li Yi , Zhang Lin , Hu Enlai , Zhao Dian , Guo Hai , Qian Guodong 
Published: June 2024

AbstractThermo‐responsive smart materials have aroused extensive interest due to the particular significance of temperature sensing. Although various photoluminescent materials are explored in thermal detection, it is not applicable enough in X‐ray radiation environment where the accuracy and reliability will be influenced. Here, a strategy is proposed by introducing the concept of radio‐luminescent functional building units (RBUs) to construct thermo‐responsive lanthanide metal‐organic frameworks (Ln‐MOFs) scintillators for self‐calibrating thermometry. The rational designs of RBUs (including organic ligand and Tb3+/Eu3+) with appropriate energy levels lead to high‐performance radio‐luminescence. Ln‐MOFs scintillators exhibit perfect linear response to X‐ray, presenting low dose rate detection limit (min ≈156.1 nGyairs‐1). Self‐calibrating detection based on ratiometric XEL intensities is achieved with good absolute and relative sensitivities of 6.74 and 8.1%K‐1, respectively. High relative light yield (max ≈39000 photons MeV−1), imaging spatial resolution (max ≈18 lp mm‐1), irradiation stability (intensity ≈100% at 368 K in total dose up to 215 Gyair), and giant color transformation visualization benefit the applications, especially the in situ thermo‐responsive X‐ray imaging. Such strategy provides a promising way to develop the novel smart photonic materials with excellent scintillator performances.
In Situ Self‐Reconfiguration Induced Multifunctional Triple‐Gradient Artificial Interfacial Layer toward Long‐Life Zn‐Metal Anodes
Authors: Shao Zhipeng , Lin Lin , Zhuang Wubin , Liu Shizhuo , Yang Peng , Zhu Kaiping , Li Chaowei , Guo Gengde , Wang Wenhui , Zhang Qichong , Yao Yagang 
Published: June 2024

AbstractAqueous Zn‐ion batteries featuring with intrinsic safety and low cost are highly desirable for large‐scale energy storage, but the unstable Zn‐metal anode resulting from uncontrollable dendrite growth and grievous hydrogen evolution reaction (HER) shortens their cycle life. Herein, a feasible in situ self‐reconfiguration strategy is developed to generate triple‐gradient poly(diallyldimethylammonium) bis(trifluoromethanesulfonyl)imide (PDDA‐TFSI)‐Zn5(OH)8Cl2·H2O‐Sn (PT‐ZHC‐Sn) artificial layer. The resulting triple‐gradient interface consists of the spherical top layer PT with cation confinement and H2O inhibition, the dense intermediate layer ZHC nanosheet with Zn2+ conduction and electron shielding, and the bottom layer Znophilic Sn metal. The well‐designed triple‐gradient artificial interfacial layer synergistically facilitates rapid Zn2+ diffusion to regulate uniform Zn deposition and accelerates the desolvation process while suppressing HER. Consequently, the PT‐ZHC‐Sn@Zn symmetric cell achieves an ultralong lifespan over 6500 h at 0.5 mA cm−2 for 0.5 mAh cm−2. Furthermore, a full battery coupling with MnO2 cathode exhibits a 17.2% increase in capacity retention compared with bare Zn anode after 1000 cycles. The in situ self‐reconfiguration strategy is also applied to prepare triple‐gradient PT‐ZHC‐In, and the assembled Zn//Cu cell operates steadily for over 8400 h while maintaining Coulombic efficiency of 99.6%. This work paves the way to designing multicomponent gradient interface for stable Zn‐metal anodes.
Aptamer‐Based DNA Allosteric Switch for Regulation of Protein Activity
Authors: Sun Hongzhi , Zhao Di , He Yating , Meng Hong‐Min , Li Zhaohui 
Published: June 2024

AbstractAllostery is a fundamental way to regulate the function of biomolecules playing crucial roles in cell metabolism and proliferation and is deemed the second secret of life. Given the limited understanding of the structure of natural allosteric molecules, the development of artificial allosteric molecules brings a huge opportunity to transform the allosteric mechanism into practical applications. In this study, the concept of bionics is introduced into the design of artificial allosteric molecules and an allosteric DNA switch with an activity site and an allosteric site based on two aptamers for selective inhibition of thrombin activity. Compared with the single aptamer, the allosteric switch possesses a significantly enhanced inhibition ability, which can be precisely regulated by converting the switch states. Moreover, the dynamic allosteric switch is further subjected to the control of the DNA threshold circuit for realizing automatic concentration determination and activity inhibition of thrombin. These compelling results confirm that this allosteric switch equipped with self‐sensing and information‐processing modules puts a new slant on the research of allosteric mechanisms and further application of allosteric tactics in chemical and biomedical fields.
Flexible Dielectric Materials: Potential and Applications in Antennas and RF Sensors
Authors: Hussain Musa , Zahra Hijab , Abbas Syed Muzahir , Zhu Yong 
Published: June 2024

AbstractDielectrics are non‐conducting substances that are primarily utilized to hold electric charges. These materials are widely employed in the field of chemical mechanical, civil and structural engineering, because of their inherent insulating properties. Besides these domains, dielectric materials are also used in electrical and electronic applications. Dielectric materials have shown an ever‐increasing potential in recent years in the fabrication of antennas, sensors, and optical devices that are extensively utilized for on‐body, environmental, robotics, and biomedical applications. With inherent electrostatic shielding, insulation, and dielectric relaxations, these materials are used in intelligent electronic devices used for biomedical applications, smart devices, vehicles, and future IoT applications. Numerous applications necessitate multiple kinds of dielectric, classified based on their polarization, flexibility, thickness, dielectric constant, and specific application. In this extensive research review, the characteristics and various aspects of dielectric materials are discussed, followed by a thorough and detailed review of flexible dielectrics and their usage in flexible electronics. Additionally, the practicality and applications of these materials which come from a variety of publications in the literature are also discussed. Moreover, in‐depth study of dieletrics in sensors and RF applications are performed.
Highly adhesive and impact‐strengthening supramolecular polyurethane derived from facile incorporation of UPy motifs toward energy dissipation binding applications
Authors: Li Zixian , Zhu Jun , Niu Peixin , Wang Hui , Sun Ailing , Wei Liuhe , Huang Xiancong , Chen Junxian , Li Yuhan 
Published: June 2024

AbstractThe implementation of hot melt adhesives reaching structural adhesion with both impact resistance and detachability is of prospective industry value but still remains challenging. In this work, 2‐amino‐4‐hydroxy‐6‐methylpyrimidine serving as both chain extender and end‐capping reagent due to its isomerism, was developed to construct a supramolecular polyurethane‐derived hot melt structural adhesive. The as‐synthesized PUM elastomers occurs obvious decrease of molecular weight at 80°C compared to room temperature, revealing the existence of self‐complementary 2‐ureido‐4[1H]‐pyrimidinone (UPy) motifs at chain ends. This unique structure allows to chemically incorporate abundant hierarchical and quadruple hydrogen bonding moieties, which results in remarkable enhancement of shear strength, ranging from 6.4 to 16.6 MPa. More importantly, it also exhibits unique impact‐strengthening and reproducible adhering ability. The Hopkinson‐press‐bar and cyclic tensile tests manifest that quadruple hydrogen bonds play a pivotal role in buffering external forces and increasing energy dissipation when exposed to high velocity impacts. The true stress and strain synchronously increase as the strain rate augments while the shear strength can even roar up to ~18 MPa at high tensile speed. With regard to mild synthetic conditions, atomic economic use of reactants, it is promising that this material has industrial potential to be utilized in applications referred to energy‐absorption and reproducible structural adhesion.
Nitrite Electroreduction Enhanced by Hybrid Compounds of Keggin Polyoxometalates and 1‐Butyl‐3‐Vinylimidazolium
Authors: Zhou Yulin , Sun Jing , Gallet Sébastien , Raya Jesus , Boudon Corinne , Bonnefont Antoine , Ruhlmann Laurent , Badets Vasilica 
Published: June 2024

AbstractWe describe here an immobilization method of four Keggin‐type polyoxometalates (POMs) ([H2W12O40]6−, [BW12O40]5− [SiW12O40]4−, [PW12O40]3−) by using the reaction with an ionic liquid, 1‐butyl‐3‐vinylimidazolium (BVIM) bromide. The reaction yields a hybrid material (BVIM‐POM) as a water‐insoluble salt. The chemical structure of both compounds is preserved, as indicated by infrared spectroscopy (FT‐IR), although with a reduced crystallinity (shown by X‐ray diffraction analysis) due to a decrease of water content (shown by thermogravimetric analysis). Cross polarization 1H‐31P NMR evidenced the presence of BVIM in the structure of (BVIM)3[PW12O40]. The salt is mixed with carbon powder and Nafion to prepare an ink and casted on glassy carbon electrodes. The electrochemical behavior of immobilized POMs material is preserved. The electrochemical activity for nitrite reduction is measured by cyclic voltammetry and differential electrochemical mass spectrometry (DEMS). It was observed that the reduction current of 10 mM HNO2 at pH 1 in 0.5 M Na2SO4 is enhanced in the presence of these hybrid materials. DEMS has evidenced the formation of nitrous oxide (N2O) at potentials more positive compared to the use of parent POMs in solution.
Synthesis, Characterization and Energetic Properties of Hydroxymethyl‐Bishomocubanone Derivatives
Authors: Lal Sohan , Rao Cheekatla Subba , Suresh Alati , Ayyagari Narasimham , Mallick Lovely , Pallikonda Gangaram , Desai Poonam , Ahirwar Parmanand , Chowdhury Arindrajit , Kumbhakarna Neeraj , Namboothiri Irishi N. N. 
Published: June 2024

AbstractThe present work reports synthesis, characterization and theoretical insights on novel hydroxymethyl‐bishomocubanone derivatives. Twelve new bishomocubanes (BHCs) were synthesized and fully characterized by various spectroscopic techniques and single crystal X‐ray analysis. The densities of the title compounds were in the range of 1.30–1.59 g/cm3. Density‐functional theory (DFT) based calculations at B3LYP/6‐311++G(d,p) level of theory were performed on ten selected BHC based cage compounds. Propulsive and ballistic properties of newly synthesized hydroxymethyl‐bishomocubanone derivatives in solid and liquid propulsion systems were calculated, and the results suggested that these compounds are superior to conventional fuel RP1 and binder HTPB. The detonation parameters revealed that these compounds are not explosive in nature and safe to use as solid propellants. Furthermore, kinetic and thermal stabilities of the title compounds were determined by HOMO‐LUMO energy gap, ESP maps, impact sensitivity (h50) and bond dissociation energies (BDEs) followed by thermogravimetric analysis (TGA) and differential thermal analysis (DTA). Three compounds, a dinitroazide (Isp,vac=310.98 s), a dinitrate (Isp,vac=309.51 s), and a dinitronitrate (Isp,vac=309.20s) were found to be excellent candidates for volume limited applications.