bluuebunny/crossref_metadata_2025_split huggingface dataset:
Midtreatment 18F‐fluorodeoxyglucose positron‐emission tomography in aggressive non‐Hodgkin lymphoma
Authors: Zinzani Pier Luigi , Gandolfi Letizia , Broccoli Alessandro , Argnani Lisa , Fanti Stefano , Pellegrini Cinzia , Stefoni Vittorio , Derenzini Enrico , Quirini Federica , Baccarani Michele 
Published: October 2010

AbstractBACKGROUND:The use of 18F‐fluorodeoxyglucose positron‐emission tomography (PET) scan has increased considerably in the clinical management of non‐Hodgkin lymphoma patients, and its role as a prognostic factor during chemotherapy has been established recently.METHODS:Between May 2003 and May 2009, 91 newly diagnosed patients with primary mediastinal large B‐cell lymphoma (PMLBCL) and diffuse large B‐cell lymphoma (DLBCL) were treated with 12 weekly cycles of rituximab‐MACOP‐B (n = 12 patients with PMLBCL), 6 cycles of rituximab‐CHOP21 (n = 65 patients with DLBCL, aged < 60 years and 1 patient with PMLBCL), or 8 weekly cycles of rituximab‐VNCOP‐B (n = 13 DLBCL patients, aged ≥ 60 years). All patients underwent a staging PET examination at baseline and a midtreatment (interim) PET examination after 6 weeks of rituximab‐MACOP‐B treatment, 3 cycles of rituximab‐CHOP21 treatment, or 4 weeks of rituximab‐VNCOP‐B treatment and again at the end of the chemo‐immunotherapy regimen.RESULTS:At midtreatment evaluation, 35 patients showed a persistently positive PET scan; only 6 (17%) of these patients achieved a continuous complete response (CCR). However, 56 patients presented with a negative interim PET, and 50 (89%) of these patients achieved and maintained a CCR. Comparison between the 2 PET groups indicated a statistically significant association between PET findings and event‐free survival (P = .0001) and overall survival (P = .0001).CONCLUSIONS:The results of this study indicated that midtreatment PET may represent a significant step forward in helping physicians make crucial decisions on further treatment. Cancer 2011. © 2010 American Cancer Society.
Combined modality therapy of cT2N0M0 esophageal cancer
Authors: Kountourakis Panteleimon , Correa Arlene M. , Hofstetter Wayne L. , Lee Jeffrey H. , Bhutani Manoop S. , Rice David C. , Komaki Ritsuko , Maru Dipen M. , Ross William A. , Vaporciyan Ara , Swisher Stephen G. , Ajani Jaffer A. 
Published: October 2010

AbstractBACKGROUND:Treatment strategy for patients with adequately staged cT2N0M0 carcinoma of the thoracic esophagus is currently a subject of debate. This study analyzed the largest series of consecutive cT2N0M0 esophageal cancer patients treated with preoperative chemoradiotherapy.METHODS:Data from all patients with cT2N0M0 (assessment included endoscopic ultrasonography and computed tomography of the chest and abdomen) thoracic esophageal cancer who were treated with preoperative chemoradiation between 1997 and 2009 were analyzed. The Cox regression model and Kaplan‐Meier plots were used to analyze the data.RESULTS:Data from 49 patients were analyzed. The median follow‐up was 28.46 months. Male sex and adenocarcinoma histology predominated. Pathologic complete response was observed 19 (39%) patients. The 10‐year actuarial overall survival (OS) for adenocarcinoma patients was >60%. In the univariate analysis for OS, squamous histology (P = .006), smoking (P = .015), and alcohol consumption (P = .032) were found to be associated with poor OS. In the univariate analysis for disease‐free survival (DFS), squamous histology (P = .009) and smoking (P = .014) were associated with poor DFS. In the multivariate analysis for OS, smoking was an independent prognosticator (P = .02). In the multivariate analysis for DFS, advanced pathologic stage (P = .05) and lymph node metastases (P = .006) were independent prognosticators. Patients with adenocarcinoma (P = .002) and those with pathologic N0 disease had better OS and DFS. Upward stage migration occurred in only 10% of patients.CONCLUSIONS:These data suggest that smoking and alcohol influence the long‐term outcome of patients with cT2N0M0 disease. Adenocarcinoma patients treated with trimodality therapy had an excellent actuarial 10‐year OS and a high rate of pathologic complete response. Trimodality therapy should be prospectively compared with primary surgery in these patients. Cancer 2011. © 2010 American Cancer Society.
A Phase 2 study of combination therapy with arsenic trioxide and gemtuzumab ozogamicin in patients with myelodysplastic syndromes or secondary acute myeloid leukemia
Authors: Sekeres Mikkael A. , Maciejewski Jaroslaw P. , Erba Harry P. , Afable Manuel , Englehaupt Ricki , Sobecks Ronald , Advani Anjali , Seel Sherry , Chan Josephine , Kalaycio Matt E. 
Published: October 2010

AbstractBACKGROUND:Higher‐risk myelodysplastic syndromes (MDS) are similar pathobiologically to acute myeloid leukemia (AML), particularly in older adults. AML therapies thus may have activity in MDS. In the current study, phase 2 study data of arsenic trioxide (ATO) and gemtuzumab ozogamicin (GO) in CD33‐positive patients with MDS and secondary AML (sAML) were presented.METHODS:Between June 2004 and February 2006, 30 patients with higher‐risk MDS or sAML received ATO (at a dose of 0.25 mg/kg intravenously for 5 days during Week 1, then twice weekly during Weeks 2‐12) and GO (at a dose of 3 mg/m2 on Day 8) for 1 or 2 cycles of 12 weeks each. The primary endpoint was response as per MDS or AML International Working Group (IWG) criteria. Adverse events were collected throughout treatment. Patients were followed for a minimum of 3 years for survival.RESULTS:The median patient age was 69 years. A total of 18 patients had MDS, 12 had sAML, and 19 had been previously treated. Seventeen patients (57%) completed ≥1 cycle, and 7 patients (23%) completed 2 cycles. IWG responses occurred in 9 patients (30%) according to IWG MDS criteria (including 2 of 7 patients who failed hypomethylating agents) and 3 of 12 AML patients (25%) according to IWG AML criteria. Grade 3/4 (according to National Cancer Institute Common Toxicity Criteria [version 3.0]) thrombocytopenia occurred in 47% of patients, neutropenia in 63%, and anemia in 37% of patients. The median overall survival was 9.7 months (28.6 months in responders and 7.6 months in nonresponders; P <.001). Patients who completed 2 cycles of therapy spent a median of 13 days in the hospital.CONCLUSIONS:Combination therapy with ATO and GO was found to have acceptable response rates and toxicity, and may be a viable treatment option to standard induction therapy, particularly for patients who fail therapy with hypomethylating agents. Cancer 2011. © 2010 American Cancer Society.
Subcellular distribution of connexin45 in OFF bipolar cells of the mouse retina
Authors: Hilgen Gerrit , von Maltzahn Julia , Willecke Klaus , Weiler Reto , Dedek Karin 
Published: October 2010

AbstractIn the mouse retina, connexin45 (Cx45) participates in the gap junction between ON cone bipolar cells and AII amacrine cells, which constitutes an essential element of the primary rod pathway. Although it has been shown that Cx45 is also expressed in OFF bipolar cells, its subcellular localization and functional role in these cells are unknown. Here, we analyzed the localization of Cx45 on OFF bipolar cells in the mouse retina. For this, we used wild‐type mice and a transgenic mouse line that expressed, in addition to native Cx45, a fusion protein consisting of Cx45 and the enhanced green fluorescent protein (EGFP). Cx45‐EGFP expression generates an EGFP signal at gap junctions containing Cx45. Combining immunohistochemistry with intracellular injections, we found that Cx45 was present on dendrites and axon terminals of all OFF bipolar cell types. Cx45 was not found at intersections of two terminal processes of the same type, suggesting that Cx45 might not form gap junctions between axon terminals of the same OFF bipolar cell type but rather might connect OFF bipolar cells to amacrine or ganglion cells. In OFF bipolar cell dendrites, Cx45 was found predominantly in the proximal outer plexiform layer (OPL), well below the cone pedicles. Cx45 did not colocalize with Cx36, which is found predominantly in the distal OPL. We conclude that Cx45 is expressed on OFF bipolar cell dendrites, presumably forming gap junctions with cells of the same type, and on OFF bipolar cell axon terminals, presumably forming heterologous gap junctions with other retinal neurons. J. Comp. Neurol. 519:433–450, 2011. © 2010 Wiley‐Liss, Inc.
Uptake of Formic Acid on Thin Ice Films and on Ice Doped with Nitric Acid between 195 and 211 K
Authors: Romanias Manolis N. , Zogka Antonia G. , Stefanopoulos Vassileios G. , Papadimitriou Vassileios C. , Papagiannakopoulos Panos 
Published: October 2010

AbstractThe adsorption of formic acid on thin ice films and on ice doped with nitric acid (1.96, 7.69 and 53.8 wt %) is studied as a function of temperature T=195–211 K and gas concentration (0.33–10.6)×1011 molecule cm−3. Experiments are performed in a Knudsen flow reactor coupled with a quadrupole mass spectrometer. The initial uptake coefficients γ are strongly and inversely dependent on the ice temperature. Initial uptake is determined at low surface coverages and ranges from (0.65–3.78)×10−3. The adsorption uptake of formic acid on pure ice films and on ice lightly doped with HNO3 is a reversible process, and the adsorption isotherms exhibit Langmuir behaviour. Nmax(1) is (2.94±0.67)×1014 molecule cm−2, in good agreement with previous measurements. The temperature dependence of KLin is very well represented by the expression: KLin(1)=(1.43±0.32)×10−8 exp[(4720±520)/T] cm3 molecule−1; the quoted uncertainty is at the 95 % level of confidence and includes systematic uncertainties. Formic acid uptakes on ice films highly doped with HNO3 (53.8 wt %) are two orders of magnitude higher than those measured on pure ice films and irreversible, thus indicating the formation of a supercooled liquid layer on the ice films upon which dissolution of formic acid occurs. Finally, the atmospheric lifetime of formic acid due to heterogeneous loss on cirrus cloud ice particles and the removal of formic acid by adsorption are estimated under conditions related to the upper troposphere.
Impact of endoscopic ultrasound‐guided fine needle aspiration (EUS‐FNA) in lymph nodal and mediastinal lesions: A multicenter experience
Authors: Zeppa Pio , Barra Enrica , Napolitano Vincenzo , Cozzolino Immacolata , Troncone Giancarlo , Picardi Marco , De Renzo Amalia , Mainenti Pier Paolo , Vetrani Antonio , Palombini Lucio 
Published: October 2010

AbstractEndoscopic ultrasound‐guided fine needle aspiration (EUS‐FNA) is an established procedure in lung cancer (LC) staging and in the diagnosis of mediastinal masses. Most of the experiences reported refer to single specialized centers where dedicated teams of endoscopists and pathologists perform the procedure. We report the EUS‐FNA experience of a cooperation group involving clinicians and cytopathologists from three hospitals. Fifty‐seven consecutive EUS‐FNA of mediastinal nodes in LC patients, eight mediastinal and two subdiaphragmatic masses were collected in 3 years. EUS‐FNA was performed by two endoscopists and three experienced pathologists. On‐site evaluation was performed in all cases by the three cytopathologists. Lymph node negative cases underwent surgery, which confirmed the cytological diagnoses but also detected two false negatives. Four of the 10 EUS cytological diagnoses of mediastinal and subdiaphragmatic masses were histologically confirmed. All EUS diagnoses were blindly reviewed by three pathologists to assess intra and interpersonal reproducibility. FNA‐EUS diagnoses were: 10 inadequate (17%), 10 negative (17%), 4 suspicious (7%) and 33 positive (59%). Diagnoses of mediastinal and subdiaphragmatic masses were: relapse of lung carcinoma (3), mesenchimal tumor not otherwise specifiable (3), gastrointestinal stromal tumor (GIST) (1), esophageal carcinoma (2) and paraganglioma (1). The sensitivity attained was 85% and the specificity 100%; revision of the slides demonstrated a significant diagnostic reproducibility of the three cytopathologists (P < 0.5). The sensitivity and specificity attained were similar to those reported in the literature suggesting that experienced cytopathologists and endoscopists from different institutions can employ the same procedure reaching comparable results. Diagn. Cytopathol. 2010. © 2010 Wiley‐Liss, Inc.
Lack of motor neuron differentiation is an intrinsic property of the mouse secondary neural tube
Authors: Shum Alisa S.W. , Tang Louisa S.C. , Copp Andrew J. , Roelink Henk 
Published: October 2010

AbstractThe cranial part of the amniote neural tube is formed by folding and fusion of the ectoderm‐derived neural plate (primary neurulation). After posterior neuropore closure, however, the caudal neural tube is formed by cavitation of tail bud mesenchyme (secondary neurulation). In mouse embryos, the secondary neural tube expresses several genes important in early patterning and induction, in restricted domains similar to the primary neural tube, yet it does not undergo neuronal differentiation, but subsequently degenerates. Although the secondary neural tube, isolated from surrounding tissues, is responsive to exogenous Sonic Hedgehog proteins in vitro, motor neuron differentiation is never observed. This cannot be attributed to the properties of the secondary notochord, since it is able to induce motor neuron differentiation in naive chick neural plate explants. Taken together, these results support that the lack of motor neuron differentiation is an intrinsic property of the mouse secondary neural tube. Developmental Dynamics 239:3192–3203, 2010. © 2010 Wiley‐Liss, Inc.
Are runoff processes ecologically or topographically driven in the (sub) humid Ethiopian highlands? The case of the Maybar watershed
Authors: Bayabil Haimanote K. , Tilahun Seifu A. , Collick Amy S. , Yitaferu Birru , Steenhuis Tammo S. 
Published: October 2010

AbstractUnderstanding the basic runoff processes in the Ethiopian highlands is vital for effective management and utilization of water resources and soil conservation planning. An important question for judging the effectiveness of conservation practices is whether runoff is affected by ecology (mainly type of crop) or topography (landscape). A study was conducted in the 113 ha watershed of Maybar, located in the highlands. This watershed has long‐term records of rainfall and discharge. To study runoff processes, piezometers were installed in eight transects up and down the slope. In addition, infiltration rates (measured earlier) were compared with rainfall intensities. The results show that the amount of runoff at the test plots was greater for cropland located on mild to intermediate slopes than for grasslands and woodlands on the steeper slopes. Water tables were closer to the surface on cropland for the mild to intermediate slopes than on grasslands and in woodlands for the steeper slopes. Thus, although water table depths and plot runoff were inconclusive on the type of runoff mechanisms, infiltration rates that were generally in excess of the rainfall rates imply that any ecological effect on the amount of surface runoff is small. This is because water infiltration is independent of crop type. Only in cases where the soil was saturated did runoff occur. Piezometer readings show that saturation occurs at the foot of the steep slopes and, therefore, it demonstrates that topographic processes are dominant. Ecology becomes important when infiltration rates are in the same order as the rainfall intensities. Copyright © 2010 John Wiley & Sons, Ltd.
Binding of Catechols to Iron(III)–Octaethylporphyrin: An Experimental and DFT Investigation
Authors: Chaudhary Arvind , Patra Ranjan , Rath Sankar Prasad 
Published: October 2010

AbstractThe synthesis, X‐ray structure, and properties of high‐spin, five‐coordinate catecholate complexes of (octaethylporphyrinato)iron(III), FeIII(OEP)(L) (L: catecholate monoanion), are reported here for the first time. In these complexes, catechol binds in an η1‐fashion as an axial ligand, which is supported by DFT calculations. The Fe–O–C angles of FeIII(OEP)(Hcat), FeIII(OEP)(4‐tBu‐Hcat), FeIII(OEP)(4‐NO2‐Hcat), and FeIII(OEP)(sal) are 119.5, 125.1, 122.2, and 124.3°, respectively. FeIII(OEP)(Hcat) has the smallest Fe–O–C angle in addition to the smallest dihedral angle of 26.2° between the planes of the porphyrin and axial catechol ligand among all phenolate complexes of iron(III)–porphyrins. In comparison to those of FeIII(OEP)(OPh) and FeIII(OEP)(4‐tBu‐Hcat), the Fe–O bond in FeIII(OEP)(Hcat) is elongated by 0.064 and 0.038 Å, respectively. This is due to the H‐bonding interactions in FeIII(OEP)(Hcat) and not caused by steric hindrance. In the 1H NMR spectra of the complexes, the signals of the ortho‐ and para‐protons of catechol are shifted upfield, whereas those of the meta‐protons are shifted downfield. The alternating shift pattern observed is due to negative and positive spin densities on the catechol carbon atoms and is indicative of π‐spin delocalization on the catecholato ligand. Electrochemical data reveal that the complexes undergo three one‐electron oxidations and a single one‐electron reduction. Based on spectroelectrochemical and DFT studies, the first oxidation is assigned to a catechol‐to‐semiquinone transformation and the second and third oxidations are found to be porphyrin‐ring‐centered.
Woody biomass and mill waste utilization opportunities in Alabama: Transportation cost minimization, optimum facility location, economic feasibility, and impact
Authors: Aksoy Burak , Cullinan Harry , Webster David , Gue Kevin , Sukumaran Sujith , Eden Mario , Sammons Norman 
Published: October 2010

AbstractFour biorefinery technologies were studied for feedstock allocation, optimum facility location, economic feasibility, and their economic impacts on Alabama. The studied technologies are: (1) circulated fluidized bed gasification of woody biomass for Fischer‐Tropsch (F‐T) fuels and power production; (2) simultaneous saccharification and fermentation (SSF) of paper sludge for ethanol production; (3) direct spouted bed (DSB) gasification with air and steam of woody biomass for power; and (4) direct combustion of woody biomass for power production. The optimum biorefinery locations for all four processes were southwestern Alabama. The average transportation distance for woody biomass was about 32 miles (51.5 km) to the biorefinery plants; however, longer transportation distances were required for paper sludge where the feedstock is provided by the pulp and paper plants in the region. The SSF process along with the DSB gasification process were the only economically feasible biorefinery technologies with an over 80 and 22.5% internal rate of return, respectively. Economic impacts of all the studied biorefinery technologies were comparable to each other. © 2010 American Institute of Chemical Engineers Environ Prog, 2010.
Equilibrium and kinetic studies of the adsorption of basic dye from aqueous solutions by zeolite synthesized from bagasse fly ash
Authors: Shah Bhavna A. , Patel Harendra D. , Shah Ajay V. 
Published: October 2010

AbstractThis study is envisaged for modification of sugar industry waste bagasse fly ash (BFA) into a beneficial sorbent zeolite (ZFA) having improved morphology for the effective removal of basic dye methylene blue (MB) from aqueous solution. BFA was efficiently transformed to ZFA by alkaline hydrothermal treatment. Both the virgin and treated BFA were characterized using various techniques to obtain its physical and chemical constituents. The major change in the morphology of BFA and ZFA was examined by X‐ray diffraction, scanning electron microscopy, and Fourier transform infrared spectroscopy. Modified adsorbent ZFA showed surface with deeper pore, indicating vanishing crystalline glass phase of BFA. The equilibrium and kinetic studies are carried out with the synthetic solutions of MB. It was found that the solute removal is favored at a lower solute concentration, increased agitation time, increased dose of adsorbent, and higher temperature. The adsorption capacities of BFA and ZFA were found to be 71% and 45%, respectively, for removal of MB at optimized conditions. Langmuir, Freundlich, and Dubinin‐Radushkevich isotherm models were adopted to describe the adsorption isotherms. Adsorption isotherms of MB dye could be best modeled by Dubinin‐Radushkevich isotherm for ZFA and Langmuir isotherm for BFA. The results clearly showed that the removal capacity of ZFA was seen to be higher than that of BFA. © 2010 American Institute of Chemical Engineers Environ Prog, 2010.
Expressed emotion measure adaptation into a foreign language
Authors: Rein Z. , Duclos J. , Perdereau F. , Curt F. , Apfel Alexandre , Wallier J , Verdier A. , Fermanian J. , Falissard B. , Zaden S. , Godart N. T. 
Published: October 2010

AbstractExpressed emotion (EE) measures have been created in English; adaptation into a foreign language is difficult. The aim of this study was to adapt the five minutes speech sample (FMSS), with a designed procedure ensuring optimum quality of the adaptation, and thus better trans‐cultural validity. A strategy for improving inter‐rater agreement comprised three phases: (1) phase of initial ratings (70 French samples), (2) experimental phase in two steps: ratings of 40 other samples in French, followed by analysis of differences between the French‐language ratings and English‐language ratings and (3) final rating phase of the initial 70 samples. For each phase, the κ coefficients measuring inter‐rater agreement were calculated and compared using a bootstrap procedure. The improvements between these scorings were significant at p < 0.05 (phase 2 initial versus phase 2 final and phases 1 versus 3). The French inter‐rater agreement significantly improved after this procedure. Copyright © 2010 John Wiley & Sons, Ltd and Eating Disorders Association.
Interpreting luminescence data from a portable OSL reader: three case studies in fluvial settings
Authors: Muñoz‐Salinas Esperanza , Bishop Paul , Sanderson David CW , Zamorano Jose‐Juan 
Published: October 2010

AbstractOptically stimulated luminescence (OSL) is a technique that has been applied from the mid‐1980s, mainly for sediment dating. The OSL technique is based on sample stimulation by light to determine the luminescence signal that is stored in the crystal lattices of sediment grains after deposition, burial by later sediment and subsequent exposure to ionizing radiation from radioactive elements in the surrounding sediment. In such sediment dating, two parameters are required: the equivalent dose (i.e. the luminescence signal stored in the grains), and the dose rate (i.e. the ionizing energy from α, β and γ radiation emitted by naturally occurring radioisotopes in the deposit, plus the effects of cosmic radiation). In this research, the OSL technique is not used for dating. The study goal is to analyse only the luminescence signals (the total photon counts) in polymineral samples obtained after light stimulation in the blue (BLSL) and infrared (IRSL) wavelengths using a portable OSL reader designed and built at the Scottish Universities Environmental Research Centre (SUERC). Three fluvial case studies – from Cambodia, Australia and Mexico – are used to illustrate the geomorphological interpretations possible with the portable OSL reader data from sediments resulting from a range of different depositional processes. The case studies show that aspects of sediment's transport and depositional processes can be inferred from the portable OSL reader data, providing valuable insights into geomorphological history. Copyright © 2010 John Wiley & Sons, Ltd.