bluuebunny/crossref_metadata_2025_split huggingface dataset:
Modification of the SF‐36 for a Headache Population Changes Patient‐Reported Health Status
Authors: Magnusson Jane E. , Riess Constance M. , Becker Werner J. 
Published: May 2012

Background.— Using standard quality of life and disability measures may not accurately capture these constructs in specific health populations such as headache patients. Modifying the wording of standard measures such as the Short‐Form 36 (SF‐36) should be considered in order to make them more applicable to specific patient populations.Objective.— To investigate the possibility that headache patients may not consider their headaches when responding to SF‐36 questions pertaining to health, physical health, pain, and bodily pain.Methods.— The wording of several SF‐36 questions were adapted for a headache population by making specific reference to “headaches” when asking people to rate the impact of health issues on their life. The results of the modified “Headache” SF‐36 were compared with a similar population of transformed migraine patients who had completed the “Standard” SF‐36.Results.— Significant differences were found between scores for the “Standard” SF‐36 group and the “Headache” SF‐36 group across all SF‐36 variables except for “General Health.”Conclusions.— Misinterpretation of the concepts of “health,”“physical health,”“pain,” and “bodily pain,” although commonly used by the SF‐36 in many populations, could influence responses on this measure, as respondents may not relate their head/headaches to these constructs. To ensure that accurate data are obtained in relation to the quality of life of headache patients, consideration should be given to using a form of the SF‐36 that has been modified to allow appropriate interpretation of the questions completed by headache patients.
Depressive and anxiety disorders in epilepsy: Do they differ in their potential to worsen common antiepileptic drug–related adverse events?
Authors: Kanner Andres M. , Barry John J. , Gilliam Frank , Hermann Bruce , Meador Kimford J. 
Published: May 2012

SummaryPurpose:  To compare the effect of anxiety disorders, major depressive episodes (MDEs), and subsyndromic depressive episodes (SSDEs) on antiepileptic drug (AED)–related adverse events (AEs) in persons with epilepsy (PWE).Methods:  The study included 188 consecutive PWE from five U.S. outpatient epilepsy clinics, all of whom underwent structured interviews (SCID) to identify current and past mood disorders and other current Axis I psychiatric diagnoses according to Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, Text Revision (DSM‐IV‐TR) criteria. A diagnosis of SSDE was made in patients with total Beck Depression Inventory‐II (BDI‐II) scores >12 or the Centers of Epidemiologic Studies‐Depression (CES‐D) > 16 (in the absence of any DSM diagnosis of mood disorder. The presence and severity of AEs was measured with the Adverse Event Profile (AEP).Key Findings:  Compared to asymptomatic patients (n = 103), the AEP scores of patients with SSDE (n = 26), MDE only (n = 10), anxiety disorders only (n = 21), or mixed MDE/anxiety disorders (n = 28) were significantly higher, suggesting more severe AED‐related AEs. Univariate analyses revealed that having persistent seizures in the last 6 months and taking antidepressants was associated with more severe AEs. Post hoc analyses, however, showed that these differences were accounted for by the presence of a depressive and/or anxiety disorders.Significance:  Depressive and anxiety disorders worsen AED‐related AEs even when presenting as a subsyndromic type. These data suggest that the presence of psychiatric comorbidities must be considered in their interpretation, both in clinical practice and AED drug trials.
The effect of seizure focus on regional language processing areas
Authors: Duke Elizabeth S. , Tesfaye Mekdem , Berl Madison M. , Walker Jennifer E. , Ritzl Eva K. , Fasano Rebecca E. , Conry Joan A. , Pearl Phillip L. , Sato Sususmu , Theodore William H. , Gaillard William D. 
Published: May 2012

SummaryPurpose:  To determine the effect of seizure focus location within the left hemisphere on the expression of regional language dominance.Methods:  In this cross‐sectional study we investigated 90 patients (mean age 23.3 ± 12.9 years) with left hemisphere focal epilepsy (mean age onset 11.7 ± 8.3 years). Eighteen patients had a frontal lobe focus and 72 had a temporal lobe focus (43 mesial; 29 neocortical). Subjects performed an auditory word definition language paradigm using 3 Tesla blood oxygen level dependent (BOLD) EPI functional magnetic resonance imaging (fMRI). Data were analyzed in SPM2. Regional laterality indices (LIs) for inferior frontal gyrus (IFG), and Wernicke’s area (WA), were calculated using a bootstrap method. Categorical language dominance and mean LI were analyzed.Key Findings:  Mean WA LI was lower for subjects with a mesial temporal focus compared with a frontal focus (p = 0.04). There was a greater proportion of atypical language in WA for subjects with a mesial temporal focus compared with a frontal focus (χ2 = 4.37, p = 0.04). WA LI did not differ for subjects with a neocortical focus compared with a mesial focus or a frontal focus. Mean IFG LI and proportion of atypical language in IFG were similar across seizure focus groups. Age and age of onset were not correlated with mean laterality in WA or IFG. Epilepsy duration tended to be negatively correlated with WA LI (r = −0.18, p = 0.10), but not IFG LI.Significance:  Temporal lobe foci have wide‐ranging effects on the distributed language system. In contrast, the effects of a frontal lobe focus appear restricted to anterior rather than posterior language processing areas.
Successful use of fenfluramine as an add‐on treatment for Dravet syndrome
Authors: Ceulemans Berten , Boel Marc , Leyssens Katrien , Van Rossem Carolin , Neels Pieter , Jorens Philippe G. , Lagae Lieven 
Published: May 2012

SummaryPurpose:  Despite the development of new antiepileptic drugs, Dravet syndrome frequently remains therapy resistant and is a catastrophic epilepsy syndrome. Fenfluramine is an amphetamine‐like drug that has been used in the past as a part of antiobesity treatments. Because of the possible cardiac adverse effects (valve thickening, pulmonary hypertension) associated with use of fenfluramine, it was withdrawn from the market in 2001. In Belgium, a Royal Decree permitted examination of the potential anticonvulsive effects of fenfluramine in a clinical trial consisting of a small group of patients diagnosed with Dravet syndrome.Methods:  Herein, we report 12 patients, 7 female and 5 male, with a genetically proven (11 of 12) diagnosis of Dravet syndrome who received fenfluramine as add‐on therapy.Key Findings:  Their ages at their last evaluation ranged from 3–35 years. The mean dosage of fenfluramine was 0.34 (0.12–0.90) mg/kg/day. Exposure duration to fenfluramine ranged from 1–19 years. Seven of the patients who were still receiving the fenfluramine treatment at the time of the last visit had been seizure‐free for at least 1 year. In total, patients had been seizure‐free for a mean of 6 (1–19) years. In seven patients, the fenfluramine treatment was interrupted once during the follow‐up; seizures reappeared in three of the seizure‐free patients. Subsequent reintroduction of fenfluramine controlled the seizures in these three patients again. Only two patients exhibited a mild thickening of one or two cardiac valves without clinical significance.Significance:  Compared with a recent long‐term follow‐up series in which a maximum of 16% of patients with Dravet syndrome were seizure‐free, our result of 70% of patients with Dravet syndrome remaining seizure‐free is noteworthy. Given the limitations of this observational study, a larger prospective study should be undertaken to confirm these promising results.
Major depression and generalized anxiety disorder among human T‐lymphotropic virus Types I– and II–infected former blood donors
Authors: Guiltinan Anne M. , Kaidarova Zhanna , Behan Dee , Marosi Cheryl , Hutching Sheila , Kaiser Mandi , Moore Elane , DeVita Deborah , Murphy Edward L. ,   for the HTLV Outcomes Study (HOST)
Published: May 2012

BACKGROUND: Other studies have reported high rates of depression and anxiety among human T‐lymphotropic virus Type I (HTLV‐I)‐infected subjects and have even suggested that HTLV‐I causes psychiatric disease.STUDY DESIGN AND METHODS: We interviewed HTLV‐I, HTLV‐II, and demographically similar HTLV‐seronegative blood donors with the Mini‐International Neuropsychiatric Interview. Prevalences of major depression and generalized anxiety disorder in each group were calculated and compared to published US population data. Adjusted odds ratios (aOR) and 95% confidence intervals (CIs) controlling for educational achievement, alcohol intake, and self‐reported health status were calculated with multivariate logistic regression.RESULTS: Major depression was diagnosed in five (5.4%) of 93 HTLV‐I–positive subjects (aOR, 2.19; 95% CI, 0.63‐7.55) and 17 (6.6%) of 256 HTLV‐II–positive subjects (aOR, 1.61; 95% CI, 0.66‐3.927), compared to 12 (2.1%) of 585 HTLV‐seronegative blood donors. The prevalence of major depression among infected subjects was comparable to the 6.7% prevalence in the US general population. Generalized anxiety disorder was diagnosed in five (5.4%) HTLV‐I–positive subjects (OR, 2.32; 95% CI, 0.74‐7.26) and 12 (4.7%) HTLV‐II–positive subjects (OR, 1.65; 95% CI, 0.68‐4.01), compared to 15 (2.6%) seronegative subjects and 3.1% in the US general population.CONCLUSION: Major depression and generalized anxiety disorder were not significantly more prevalent among HTLV‐I– and HTLV‐II–infected former blood donors after controlling for health status and other confounding variables. HTLV‐seronegative blood donors had lower prevalences of these conditions than the US population, probably due to a “healthy blood donor effect.”
Computer Simulation of Clinical Electrophysiological Study
Authors: ZHU XIN , WEI DAMING , OKAZAKI OSAMU 
Published: May 2012

Background:

Computer simulation is an important method for the basic researches of cardiac electrophysiology to prove the mechanisms and hypotheses of cardiac arrhythmias by reproducing body surface electrocardiograms. In this research, we extend the researches of heart models to the computer simulation of clinical electrophysiological study (EPS) as a clinical application of heart models.
Method:

Through setting the standard EPS pacing protocols, including extrastimuli and incremental pacing in the heart models, we simulated the corresponding excitation propagations in the heart and the intracardiac electrograms that would be measured with catheter electrodes.
Results:

Examples of complicated cases observed during EPS are reproduced in this research, including the induction of a Wenckebach pattern, the induction and termination of supraventricular tachycardia due to the reentry loop of antidromic atrioventricular reentrant tachycardia for the Wolff‐Parkinson‐White (WPW) syndrome (Type A), and the localization of an accessory pathway for the WPW syndrome (Type A).
Conclusion:

This study demonstrates an application of whole‐heart modeling and computer simulation to clinical EPS. (PACE 2012; 35:718–729)
Subcutaneous Implantable Cardioverter Defibrillator in a Patient with Pectus Excavatum
Authors: HAMOUD AHMED , BARRY JAMES 
Published: May 2012

Sudden cardiac arrest in young healthy adults has concerned the medical and social communities due to its fatal effect.Implantable cardioverter defibrillator (ICD) has been demonstrated to be an effective measure for prevention of sudden death in patients at risk of ventricular arrhythmia. Subcutaneous ICD has been developed to overcome some problems associated with transvenous leads in the conventional ICD.In this case report, we describe the use of completely subcutaneous ICD for a young patient with pectus excavatum following presentation with out‐of‐hospital VF arrest with no complication in device or lead positioning. (PACE 2013; 36:e138–e139)
Chronic Performance of a Subcutaneous Hemodynamic Sensor
Authors: NABUTOVSKY YELENA , PAVEK TODD , TURCOTT ROBERT 
Published: May 2012

Background:

A subcutaneous photoplethysmography (PPG) sensor uses light to detect changes in vascular volume from a location outside the bloodstream. Incorporation into a chronically implanted device, such as a pacemaker or an implantable cardioverter defibrillator, may facilitate therapy optimization and disease monitoring by providing continuous assessment of hemodynamic function and arterial oxygen saturation. However, performance of a chronically placed subcutaneous sensor has not been established.
Methods:

Six dogs were implanted with 2–4 PPG sensors subcutaneously in the neck or posterior thorax. Half of the sensors were directed toward deep tissue and half toward overlying cutaneous tissue. Each sensor contained a red and an infrared light emitting diode, a photodetector, and supporting electronics, which were encapsulated in epoxy and attached to a transcutaneous connector. Data were collected at implant and every 3 ± 1 days for 4–9 months starting 3 weeks postimplant. At explant, the fibrous encapsulation was histologically analyzed.
Results:

A minimally to moderately neovascularized encapsulation formed over all sensors, consisting of fibrous and granulation tissue. Higher cardiac pulse amplitudes and direct current (DC) components were recorded in sensors oriented toward deep tissue, but no significant difference between orientations was found in respiratory wave amplitude. Cardiac pulse amplitude, respiratory wave amplitude, and DC component amplitude, as recorded by the sensor, did not significantly change over time.
Conclusions:

Despite fibrous encapsulation of PPG sensors, cardiac pulses and respiratory waves could easily be measured throughout the study and remained constant over time. These results suggest suitability of subcutaneous PPG technology for chronic applications. (PACE 2012; 35:919–926)
Accuracy of full guided vs. half‐guided implant surgery
Authors: Kühl S. , Zürcher S. , Mahid T. , Müller‐Gerbl M. , Filippi A. , Cattin P. 
Published: May 2012

AbstractObjectivesThe benefit in terms of higher accuracy for full guided implant surgery (template based guided cavity preparation and guided implant insertion) compared with half‐guided surgery (template based guided cavity preparation and free‐handed, manual implant insertion) has not been proved till now.Material and methodsA total of 38 identical implants were inserted into five human cadaver jaws, after virtual implant planning with the coDiagnostiX™ device. All cavities were drilled using templates equipped with tubes for guidance. At random, 19 implants were inserted in a free handed way (half‐guided), whereas 19 implants were inserted in a guided way through the templates tubes (full guided). Postoperative cone beam computer tomographies (CBCT) were performed, and based on image fusion the total deviations between the virtual implant positions at the implants base and tip were determined and compared between both implantation modi.ResultsThe mean difference in accuracy between both implantation modalities at the implants bases was 0.72 mm (range: 0.16–1.17 mm, SD: 0.45). The mean difference in accuracy between both modalities at the implants tips was 0.46 mm (range: 0.16–1.23 mm. SD: 0.49). Although full guided implantation showed a generally higher accuracy (mean tip: 1.54 mm, range: 0.33–3.64 mm; mean base: 1.52 mm, range: 0.4–3.54 mm) than half‐guided implantation (mean tip: 1.84 mm, range: 0.84–3.22 mm; mean base: 1.56 mm, range: 0.49–3.43 mm), the differences were not statistically significant.ConclusionsThe accuracy of half‐guided implant surgery is comparable with full guided implant surgery.
The roles of matrix metalloproteinases‐2, ‐7, ‐10 and tissue inhibitor of metalloproteinase‐1 in the pathogenesis of oral lichen planus
Authors: Rubaci Asli Hayirlioglu , Kazancioglu Hakki Oguz , Olgac Vakur , Ak Gulsum 
Published: May 2012

J Oral Pathol Med (2012) 41: 689–696Background:  The aim of this study was to investigate the roles of Matrix Metalloproteinases (MMP)‐2, Metalloproteinases‐7, Metalloproteinases‐10 and Tissue Inhibitors of Metalloproteinase‐1 (TIMP‐1) in the pathogenesis of oral lichen planus (OLP) disease in same tissue samples.Methods:  Thirty‐nine individuals [29 patients with OLP (74%) and 10 healthy control subjects (25%)] were included in our study. The mean age was 48 ± 14.39 with a range of 20–75.Results:  MMP‐2 and MMP‐7 expression was significantly different in the patient and control groups in the epithelium and the connective tissue (P < 0. 05). The ratio of MMP‐2/TIMP‐1 and MMP‐7/TIMP‐1 were higher in patient with OLP group than control group.Conclusions:  Along with the exposure of the role of MMPs activity on diseases characterized by the tissue destruction, several studies were conducted on the pharmacological control of MMPs activity. However, understanding of the biological functions of MMPs is very important for the development and implementation of MMP inhibitors in the treatment of diseases. According to the results of this study, we suggest that MMP‐2, MMP‐7, and TIMP‐1 may be involved in the formation of OLP lesions. Further studies on MMPs may be useful for understanding and treating the diseases such as OLP.
Practical capability of a DNA pool‐based genome‐wide association study using BovineSNP50 array in a cattle population
Authors: UEMOTO Yoshinobu , SASAGO Nanae , ABE Tsuyoshi , OKADA Hideki , MARUOKA Hitomi , NAKAJIMA Hiroaki , SHOJI Noriaki , MARUYAMA Shin , KOBAYASHI Naohiko , MANNEN Hideyuki , KOBAYASHI Eiji 
Published: May 2012

ABSTRACTGenome‐wide association mapping for complex traits in cattle populations is a powerful, but expensive, selection tool. The DNA pooling technique can potentially reduce the cost of genome‐wide association studies. However, in DNA pooling design, the additional variance generated by pooling‐specific errors must be taken into account. Therefore, this study aimed to investigate factors such as: (i) the accuracy of allele frequency estimation; (ii) the magnitude of errors in pooling construction and in the array; and (iii) the effect of the number of replicate arrays on P‐values estimated by a genome‐wide association study. Results showed that the Illumina correction method is the most effective method to correct the allele frequency estimation; pooling errors, especially array variance, should be taken into account in DNA pooling design; and the risk of a type I error can be reduced by using at least two replicate arrays. These results indicate the practical capability and cost‐effectiveness of pool‐based genome‐wide association studies using the BovineSNP50 array in a cattle population.
Impacts of acute imipramine treatment on plasma and brain amino acid metabolism in mice given graded levels of dietary chicken protein
Authors: NAGASAWA Mao , MURAKAMI Tatsuro , TOMONAGA Shozo , SATO Mikako , TAKAHATA Yoshihisa , MORIMATSU Fumiki , FURUSE Mitsuhiro 
Published: May 2012

ABSTRACTSeveral studies have shown a relationship between depression and animal protein intake. To evaluate whether the difference of dietary chicken protein levels induces an antidepressant‐like effect and potentiates acute antidepressant effects, three levels of dietary chicken protein were used as the representative animal protein with imipramine used as the antidepressant. In addition, the effects of dietary chicken protein on brain metabolism were evaluated. Open field test (OFT) and forced swimming test (FST) were conducted on the 27th and 28th days, respectively. OFT and FST were not influenced by both imipramine and dietary protein levels. However, characteristic effects of imipramine treatment on brain monoamine metabolism were observed in the cerebral cortex and hypothalamus. In addition, dietary protein significantly increased taurine and L‐ornithine levels even though these amino acids were not contained in the diets. In conclusion, the metabolism of several amino acids in the plasma and brain were altered by dietary chicken protein.
Diagnosis of oligodendroglioma: Molecular and classical histological assessment in the twenty‐first century
Authors: MATTHEWS Slade , SUCCAR Petter , JELINEK Herbert , MCPARLAND Brent , BUCKLAND Michael , MCLACHLAN Craig S 
Published: May 2012

AbstractAdvances in molecular genetics are currently challenging the traditional morphological categorization of gliomas. Recurrent molecular and cytogenetic aberrations add prognostic and predictive information over and above that provided by standard histomorphological techniques and may influence decisions to re‐operate or observe, to deliver radiation or not, or to administer chemotherapy to glioma patients. The importance of routine hematoxylin and eosin (H–E pathological stains cannot be underestimated, especially in resource‐poor areas and developing countries where there is likely to be a significant economic opportunity cost for molecular diagnosis services. New research tools for image analyses of histological H–E slides, such as the precise measures of cell area, curvature and nuclear roundness, may provide an increased ability to provide an accurate classification for an inherently subjective process of histological assessment. We discuss the current trends, limitations and impact of molecular classification in this mini review.
Effects of Low and High Acyl Gellan Gums on Engineering Properties of Carrot Juice
Authors: Sherafati Marjan , Kalbasi‐Ashtari Ahmad , Mousavi Seyed Mohammad Ali 
Published: May 2012

ABSTRACTThe clear juice of peeled and blanched carrot (Nantes variety) was obtained and pasteurized and its °Brix and pH were adjusted. Then different ratios (0.02, 0.025 and 0.03%) of low and high acyl (LA and HA) gellan mixed separately with carrot juice and heated up to 70C for 20 min. Later, the rheological parameters, particle size distributions, turbidities and phase decantation of each sample was evaluated after 15 days storage at 4C. The samples of LA gellan had lower turbidity, viscosity, flow indexes (n < 1) and higher consistency coefficient, surface tension, specific surface area and sediment than control. However, the rheological and sensorial characteristics of the samples with HA gellan were very similar to control. While, the LA gellan gum was not able to stabilize the carrot juice, the HA gellan with 0.03% had a great influence on stabilization of colloidal system and had the most acceptable physical and sensory characteristics in comparison with the natural pasteurized carrot juice.PRACTICAL APPLICATIONSThe pulp of carrot juice is a rich source of phytochemicals (beta carotene, antioxidants, tannins and fibers), and it is important to keep it in suspension during juice processing, storage and handling for healthy drinking.During the last few years, the production of gelatin from cattle bone (as a stabilizer of fruit juices) has faced with different religious restrictions such as Kosher and Halal. Also the emergence of bovine spongiform encephalo‐pathy virus in cattle‐raising has caused a sharp reduction in the production of this stabilizer.Recently, the high acyl and low acyl gellan gums (produced by fermentation) are used as two hydrocolloids with interesting properties in various kinds of food products. This study suggested that incorporating high acyl gellan (instead of gelatin) with fresh carrot juice provides a pleasant drink with high pulp stability, good palatability (such as flavor, appearance and consistency) and long shelf life without noticeable sediment.