bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cerebellar control over inter-regional excitatory/inhibitory dynamics discriminates execution from observation of an action
Authors: Lorenzi Roberta Maria , Korkmaz Gökçe , Alahmadi Adnan A.S. , Monteverdi Anita , Casiraghi Letizia , D’Angelo Egidio , Palesi Fulvia , Gandini Wheeler-Kingshott Claudia A.M. 
Published: May 2024

AbstractThe motor learning theory anticipates that cerebro-cerebellar loops perform sensorimotor prediction thereby regulating motor control. This operation has been identified during action execution (AE) and observation (AO) but the causal interaction between the cerebellum and cerebral cortex remained unclear. Here we used Dynamic Causal Modelling (DCM) to study functional MRI (fMRI) data obtained during a squeeze ball task in either the AE or AO conditions. In both cases, active regions included bilateral primary visual cortex (V1), left primary motor cortex (M1), left supplementary motor and premotor cortex (SMAPMC), left cingulate cortex (CC), left superior parietal lobule (SPL), and right cerebellum (CRBL). AE and AO networks showed the same fixed effective connectivity, with pathways between V1, CRBL, SMAPMC and CC wired in a closed loop. However, the cerebellar communication towards the cerebral cortex switched from excitatory in AE to inhibitory in AO. Moreover, in AE only, signal modulation was non-linear from SMAPMC to CRBL and within the CRBL self-connection, supporting the role of the CRBL in elaborating motor plans received from SMAPMC. Thus, the need for motor planning and the presence of a sensorimotor feedback in AE discriminate the modality of forward control operated by the CRBL on SMAPMC. While the underlying circuit mechanisms remain to be determined, these results reveal that the CRBL differentially controls the excitatory/inhibitory dynamics of inter-regional effective connectivity depending on its functional engagement, opening new prospective for the design of artificial sensorimotor controllers and for the investigation of neurological diseases.
Inhibition of Inflammatory Osteoclasts Enhances CGRP+TrkA+Signaling and Accelerates Callus Remodeling in Osteoporotic Fractures
Authors: Shu Yuexia , Tan Zhenyu , Pan Zhen , Chen Yujie , Wang Jielin , He Jieming , Wang Jia , Wang Yuan 
Published: May 2024

AbstractImpaired callus remodeling significantly contributes to the delayed healing of osteoporotic fractures; however, the underlying mechanisms remain unclear. Sensory neuronal signaling plays a crucial role in bone repair. In this study, we demonstrate that in ovariectomized (OVX) mice, the loss of CGRP+TrkA+sensory neuronal signaling during callus remodeling correlates with increased Cx3cr1+iOCs expression within the bone callus. Conditional knockout of Cx3cr1+iOCs restored CGRP+TrkA+sensory neuronal, enabling normal callus remodeling progression. Mechanistically, we further demonstrate that Cx3cr1+iOCs secrete seme3A in the osteoporotic fracture repair microenvironment, inhibiting CGRP+TrkA+sensory neurons’ axonal regeneration and suppressing nerve-bone signaling exchange, thus hindering bone remodeling. Lastly, in human samples, we observed an association between the loss of CGRP+TrkA+sensory neuronal signaling and increased expression of Cx3cr1+iOCs. In conclusion, enhancing CGRP+TrkA+sensory nerve signaling by inhibiting Cx3cr1+iOCs activity presents a potential strategy for treating delayed healing in osteoporotic fractures.
Dynamic and decay kinetics of H3 variants in live cells reveal the pivotal role of HIRA/NSD2 in maintaining the distinct H3.3 specific chromatin landscape
Authors: Nehru Vishal , Ball David , Mukherjee Abhishek , Kurotaki Daisuke , Chitnis Ajay , Karpova Tatiana S. , Ozato Keiko 
Published: May 2024

AbstractThe incorporation of variant histone H3.3 into the genome is tightly linked with transcriptional activity, yet its precise regulatory mechanisms remain elusive. Traditional methods like Chromatin Immunoprecipitation offer static views of H3.3 distribution, lacking dynamic insights. Here, using the SNAP tag system, we employed Fluorescence Recovery After Photobleaching (FRAP) and live-cell imaging to investigate H3.3 mobility and decay kinetics in live mouse embryonic fibroblast cells. Our focus on interferon-induced transcriptional activation revealed rapid H3.3 exchange, indicative of its transcriptional regulatory role. Transcription inhibition hindered H3.3 mobility, emphasizing its involvement in transcription. Additionally, we probed into turnover dynamics(decay) of H3.1-SNAP and H3.3-SNAP variants, uncovering differential decay rates influenced by transcriptional activity and histone modifiers such as NSD2 and HIRA. Live-cell imaging showed faster decay of H3.3 compared to H3.1, further exacerbated upon NSD2/HIRA loss. Notably, HIRA and NSD2, regulators of H3.3 dynamics, proved crucial for both H3.3 mobility and decay, underscoring their pivotal role. These findings deepen our understanding of epigenetic regulation, emphasizing the dynamic nature of histone turnover in cellular function and its implications for disease pathogenesis. Taken together, this study sheds light on the dynamic behavior of H3.3 and its regulatory mechanisms, providing valuable insights into epigenetic regulation in cellular processes and disease contexts.
Repression of PRMT activities sensitize homologous recombination-proficient ovarian and breast cancer cells to PARP inhibitor treatment
Authors: Zhang Youyou , Xu Mu , Yuan Jiao , Hu Zhongyi , Jiang Junjie , Huang Jie , Wang Bingwei , Shen Jianfeng , Long Meixiao , Fan Yi , Montone Kathleen T. , Tanyi Janos L. , Tavana Omid , Chan Ho Man , Hu Xiaowen , Zhang Lin 
Published: May 2024

AbstractAn “induced PARP inhibitor (PARPi) sensitivity by epigenetic modulation” strategy is being evaluated in the clinic to sensitize homologous recombination (HR)-proficient tumors to PARPi treatments. To expand its clinical applications and identify more efficient combinations, we performed a drug screen by combining PARPi with 74 well-characterized epigenetic modulators that target five major classes of epigenetic enzymes. Both type I PRMT inhibitor and PRMT5 inhibitor exhibit high combination and clinical priority scores in our screen. PRMT inhibition significantly enhances PARPi treatment-induced DNA damage in HR-proficient ovarian and breast cancer cells. Mechanistically, PRMTs maintain the expression of genes associated with DNA damage repair and BRCAness and regulate intrinsic innate immune pathways in cancer cells. Analyzing large-scale genomic and functional profiles from TCGA and DepMap further confirms that PRMT1, PRMT4, and PRMT5 are potential therapeutic targets in oncology. Finally, PRMT1 and PRMT5 inhibition act synergistically to enhance PARPi sensitivity. Our studies provide a strong rationale for the clinical application of a combination of PRMT and PARP inhibitors in patients with HR-proficient ovarian or breast cancer.
Leveraging growth of savings and credit cooperatives through innovative practices-cases from Uganda
Authors: Nassuna Agnes Noelin , Jeppesen Soeren , Balunywa Waswa 
Published: May 2024

PurposeThis paper explores how the growth of selected Savings and Credit Cooperatives (SACCOs) in an African setting was nurtured through innovative practices that enabled them to fulfill their roles.Design/methodology/approachThe paper applies an exploratory qualitative approach using face-to-face interviews and observation to obtain in-depth primary data. Data were then examined using thematic and matrix analyses to understand the key resources, innovative practices and growth strides in the cases studied. FindingsThe SACCOs undertook a variety of innovative practices based on resources, which included: creating teams, focusing on community needs, involving top management and all SACCOS’ members and having visionary entrepreneurial leaders. This led to an increase in outreach and savings.Originality/valueWhereas the concept of innovative practices has been widely studied, there is scanty literature on how such practices within SACCOs are developed based on the resources of SACCOs in Africa. This paper further provides new insights based on empirical data from SACCOs that applied innovative practices and were able to grow.
Industrial engineer and Industry 4.0? Empirical evidence from the Brazilian context considering the relation between competences and technologies
Authors: da Rocha Lucas Thadeu Vulcão , Pereira Lucas Ryu Morotomi , Fernandes Reimison Moreira , Melo André Cristiano Silva , da Silva Dirceu , Rampasso Izabela Simon , Anholon Rosley , Batista Martins Vitor William 
Published: May 2024

PurposeManufacturing systems have undergone radical changes because of the implementation of physical and digital innovating technologies with high levels of connectivity, interoperability and autonomy. In this regard, the objective of this study was to investigate whether industrial engineers graduated in recent years in Brazil are prepared or not to work in companies and industries within the scope of Industry 4.0 technologies in a way that they positively contribute to the implementation and management of such technologies.Design/methodology/approachTo achieve these objectives, a literature review and a survey on managers of the industrial sector acting in Brazil were carried out as the research strategies. The data collected were analyzed through a quantitative approach by means of the structural equations modeling method.FindingsThe hypothesis that the competencies of industrial engineers currently graduating in Brazil have a positive impact on the implementation and management of Industry 4.0 technologies has been confirmed. Predicting the evolution of production scenarios, understanding the interaction between organizations and their impacts on competitiveness and keeping abreast of technological advancements, organizing them and putting them to the service of business and societal demands were the competencies that obtained the highest factor loadings in the construct of industrial engineer competencies. In addition, cloud manufacturing, automation and robotization were the competencies that obtained the highest factor loadings in the industry 4.0 construct.Originality/valueThe analysis of skills development stands out as a source of competitive advantage for companies that intend to transition to a production system aligned with the principles of Industry 4.0, considering the training of professionals in an emerging economy context.
The erupting volcano: the role of the Ukraine frozen conflict and ongoing war in transforming international and European order
Authors: Smajljaj Avdi 
Published: May 2024

Purpose
The European Union (EU) and Russia are considered to be trapped into security concerns in a form of spillover, in a zero sum perspective, considering each step of the other as directed against another. Such an approach seems to prevail, after attempts of engagements for decades after the Cold War. Rather history prevailed in informing perceptions and currently driving the behaviors toward each other, in other words in othering each other.

Design/methodology/approach
Discourse analysis

Findings
The move in Eastern Europe of both parties is perceived with suspicion from both sides, materialized through their policies, culminated in clash of interests and crash of policies between both parts, manifested by Russian aggression in Ukraine in 2014 and recently in 2022 in one side, and the EU response through massive, unprecedented sanctions against Russia. This has created a context that fosters not just keeping a status quo of clash and struggle for influence between them in the region, but also nourishes further securitization of their respective policies toward the Eastern Europe and beyond. In 2014 and more recently in 2022 Russian aggression in Ukraine, the EU and Russia appear to have the same image to each other as they had during the Cold War, or even beyond. Having this in mind, this paper will address those developments, with particular focus on attempts to avoid them, the failure to do so and how they are impacting the EU, Russia and global politics in a form of emerging new world (dis)order.

Originality/value
This paper is an original paper having a critical approach toward the current conflicts going on in Eastern Europe.
The differential effects of sales control systems on salespeople’s role stressors and performance in the pharmaceutical industry
Authors: Cho Yeonjin , Nam Hyunjeong 
Published: May 2024

Purpose
This paper aims to identify and report the differential effects of activity control and capability control on role stressors, which subsequently affect salespeople’s job satisfaction and sales performance.

Design/methodology/approach
Drawing on job demands-resources (JD-R) theory, the authors defined active control and customer demandingness as the job demands and capability control as the job resource, and designed their relationship with role stressors, which are indicated as role ambiguity, role conflict and role overload. The authors enrolled a sample of 223 industrial salespeople from pharmaceutical companies. After collecting the data, the authors used structural equation modeling using AMOS to test and estimate causal relationships along with a two-step approach to examine the interaction effect. The authors have also tested the simple slope of two-way interactions. All of the measured variables were identical to those used in previous studies.

Findings
The study findings indicate that behavior-based control can be counterproductive. Reducing activity control can decrease role stress, increase job satisfaction and improve job performance; increasing capability control, however, can reduce role stress and increase job satisfaction and performance. It is also important to acknowledge the external environment of the sales context in which behavior-based control is most effective: whereas high customer demandingness and capability control are related to reduced role stress, high customer demandingness and activity control are related to increased role stress.

Practical implications
Sales managers should recognize that different control management regimes reinforce or mitigate salespeople’s job stressors and outcomes under specific conditions (i.e. work environments marked by higher or lower customer demandingness).

Originality/value
Drawing on JD-R theory, the research shows that a behavior control (i.e. activity control and capability control) has differential, and even opposite, psychological consequences.
Socio-economic dimensions and human centricity in Industry 5.0: a study on manufacturing sectors in central and Eastern European economies
Authors: Singh Devesh , Cohen Viktorija 
Published: May 2024

PurposeThis study aims to quantify the concept of Industry 5.0, with a focus on human-centricity in the manufacturing sector.Design/methodology/approachThe panel nonlinear autoregressive distributed lag method is applied to assess asymmetry and vulnerability in the food, textile, chemical manufacturing, high-tech and transportation sectors. The robustness of the results is tested using a panel Granger non-causality test and panel vector autoregressive models.FindingsThis study finds that financial unions, fair internal markets, gender and youth participation are significant factors for human centricity in the manufacturing sectors. The NARDL results suggest that both the chemical and high-tech industries human participation are insignificant in both the long run and short run. The results of the food industry are significant in both the sort run and the long run.Research limitations/implicationsManufacturing sectors need to create sustainable employment strategies that lead to stable, enduring and satisfying jobs in order to achieve human centricity. Involve skilled workers in important decision-making processes and empower them with technology.Originality/valueThis study differed from prior research in several ways. Firstly, it incorporates the social dimension as a control variable in the pursuit of I5.0 implementation across various manufacturing sectors. Secondly, it quantifies the human-centricity aspect of I5.0 within these sectors.
The effect of policy uncertainty on the volatility of bitcoin
Authors: Mahjoubi Manel , Henchiri Jamel Eddine 
Published: May 2024

Purpose
This paper aims to investigate the effect of the economic policy uncertainty (EPU), geopolitical risk (GPR) and climate policy uncertainty (CPU) of USA on Bitcoin volatility from August 2010 to August 2022.

Design/methodology/approach
In this paper, the authors have adopted the empirical strategy of Yen and Cheng (2021), who modified volatility model of Wang and Yen (2019), and the authors use an OLS regression with Newey-West error term.

Findings
The results using OLS regression with Newey–West error term suggest that the cryptocurrency market could have hedge or safe-haven properties against EPU and geopolitical uncertainty. While the authors find that the CPU has a negative impact on the volatility of the bitcoin market. Hence, the authors expect climate and environmental changes, as well as indiscriminate energy consumption, to play a more important role in increasing Bitcoin price volatility, in the future.

Originality/value
This study has two implications. First, to the best of the authors’ knowledge, the study is the first to extend the discussion on the effect of dimensions of uncertainty on the volatility of Bitcoin. Second, in contrast to previous studies, this study can be considered as the first to examine the role of climate change in predicting the volatility of bitcoin. This paper contributes to the literature on volatility forecasting of cryptocurrency in two ways. First, the authors discuss volatility forecasting of Bitcoin using the effects of three dimensions of uncertainty of USA (EPU, GPR and CPU). Second, based on the empirical results, the authors show that cryptocurrency can be a good hedging tool against EPU and GPR risk. But the cryptocurrency cannot be a hedging tool against CPU risk, especially with the high risks and climatic changes that threaten the environment.
Exploring leader’s unethical proorganizational behavior and follower attitudes toward knowledge hiding and sharing in the service industry: a social learning perspective
Authors: Masood Ayesha , Zhang Qingyu , Singh Nidhi , Meena Bhatia , Perano Mirko 
Published: May 2024

Purpose
Grounded in the framework of social learning theory (SLT), the current study explores the impact of leaders’ unethical proorganizational behavior (UPB) on their subordinates’ self-management and moral self-efficacy, which, in turn, affect knowledge hiding and sharing among followers. This study aims to examine how instrumental thinking influences the relationship between leader UPB and subordinate behaviors, shaping knowledge sharing and hiding.

Design/methodology/approach
Using a longitudinal approach, this research uses a two-wave data collection strategy with a one-month interval. The study cohort comprises 378 employees drawn from technology service firms situated in China.

Findings
Empirical findings confirm that leader UPB is linked to increased follower self-management and knowledge hiding, as well as reduced moral self-efficacy. Instrumental thinking moderates these effects, amplifying knowledge hiding and diminishing moral self-efficacy while reducing knowledge sharing.

Research limitations/implications
The study contributes to the existing literature on UPB by offering insights into the distinct consequences of leader UPB on knowledge-related behaviors of followers. Furthermore, the exploration of employees’ instrumental thinking in the context of leader UPB underscores the strategic manipulation of knowledge to fulfill individual goals, thereby enriching the underpinnings of the SLT. The study underscores the imperative for organizations to grasp the implications of UPB and underscores the necessity for stringent ethical frameworks to mitigate its deleterious impact.

Practical implications
The study contributes to the existing literature on UPB by offering insights into the distinct consequences of leader UPB on knowledge-related behaviors of followers. Furthermore, the exploration of employees’ instrumental thinking in the context of leader UPB underscores the strategic manipulation of knowledge to fulfill individual goals, thereby enriching the underpinnings of the SLT. The study underscores the imperative for organizations to grasp the implications of UPB and underscores the necessity for stringent ethical frameworks to mitigate its deleterious impact.

Originality/value
The present study addresses a gap in the current literature by elucidating the multifaceted outcomes of leaders’ UPB on paradoxical behaviors related to knowledge sharing and hiding among followers. This nuanced examination underscores the need to comprehend the intricate contingencies that accentuate the effects of UPB, particularly in the realm of leadership dynamics. Grounded in SLT, this study delves into leadership dynamics and ethical decision-making.
Markets in absence of pricing and qualification mechanisms: past, present and future warnings
Authors: Bracci Enrico , Fırtın Cemil Eren , Weichselberger Gustaf Kastberg 
Published: May 2024

PurposeThis essay focuses on an argument that challenges the notion of market reform as a desirable idea. It examines how market requirements, accounting practices, political intervention and organizational conditions interact and create conflicts in the implementation of market reform. In our case study, we aim to elucidate the detrimental effects of expanding pricing mechanisms into areas typically untouched.Design/methodology/approachThe essay adopts a critical perspective toward the marketization in the public sector organizations based on the authors' previous studies and observations of the reforms in Swedish schools over the last 30 years. The case is conceptualized within Callon’s framework of the sociology of worth.FindingsThe paper provides an example of market dynamics introduced without the presence of pricing and qualification mechanisms, resulting in a trial-and-error situation. In this context, we document and problematize a trend toward marketization that has had negative consequences for Swedish schools. In doing so, the paper shows how market requirements, accounting practices, political interventions and organizational conditions interact and create conflicts during the implementation of market reforms. The case shows the emergence of a new economic entity and its underlying rationale, the quantification/pricing mechanism, with a special emphasis on the role of accounting and the repercussions on subjectivities as values shift.Originality/valueThis paper follows up on the New Public Financial Management (NPFM) global warning debate on the emergence of pricing/charging mechanisms in public services. It provides a critical overview of the diffusion and relevance of accounting evaluation processes to sustain continuous reforms, despite claimed criticisms, limitations and (un)intended consequences. The paper also provides some reflections on new avenues for further research and some possible ways out for accounting studies.