bluuebunny/crossref_metadata_2025_split huggingface dataset:
Systematic Review: Singing-Based Interventions to Improve Physical Functions Related to Aging Voice in Older Adults
Authors: Yuen Crystal W.-N. , Ma Estella P.-M. 
Published: June 2024

Purpose:
This systematic review aimed to evaluate the effects of singing as an intervention for aging voice.

Method:
Quantitative studies of interventions for older adults with any medical condition that involves singing as training were reviewed, measured by respiration, phonation, and posture, which are the physical functions related to the aging voice. English and Chinese studies published until April 2024 were searched using 31 electronic databases, and seven studies were included. The included articles were assessed according to the Grading of Recommendations, Assessment, Development, and Evaluations rubric.

Results:
Seven studies were included. These studies reported outcome measures that were related to respiratory functions only. For the intervention effect, statistically significant improvements were observed in five of the included studies, among which three studies had large effect sizes. The overall level of evidence of the included studies was not high, with three studies having moderate levels and the rest having lower levels. The intervention activities included trainings other than singing. These non-singing training items may have caused co-intervention bias in the study results.

Conclusions:
This systematic review suggests that singing as an intervention for older adults with respiratory and cognitive problems could improve respiration and respiratory–phonatory control. However, none of the included studies covers the other two of the physical functions related to aging voice (phonatory and postural functions). The overall level of evidence of the included studies was not high either. There is a need for more research evidence in singing-based intervention specifically for patient with aging voice.
Vielfältige Entwicklungen aus Neurologie und
Psychiatrie
Authors: Reichmann Heinz 
Published: June 2024

Liebe Leserinnen und Leser der „Fortschritte der Neurologie ·
Psychiatrie“!Heute halten sie erneut ein Heft in der Hand, was sowohl neurologisch als auch
psychiatrisch relevante neue Entwicklungen zusammenfasst und diskutiert. Von Seiten
des neurologischen Fachgebietes möchte ich insbesondere auf die Arbeit von Kaulen et
al. hinweisen, die eine Zusammenfassung bezüglich Diagnostik, Symptomatik und
Therapie der häufigsten chronischen Autoimmunerkrankung des peripheren
Nervensystems, nämlich der chronischen inflammatorischen demyelinisierenden
Polyradikuloneuropathie (CIDP) vorstellen. Im Gegensatz zum Guillain-Barré-Syndrom
handelt es sich bei der CIDP um eine chronische Erkrankung, wobei die Symptome
subakut über einen Zeitraum von wenigen Wochen auftreten. Da es sich insbesondere um
eine demyelinisierende Erkrankung handelt, finden sich elektrophysiologisch
Reduktionen der Nervenleitgeschwindigkeiten und Leitungsblöcke. Die Autoren liefern
eine sehr schöne Übersicht über die typischen elektroneurographischen Kriterien für
die Diagnose der CIDP und weisen dann auf den klassischen Verteilungstyp hin, der
distal und proximal symmetrisch charakterisiert ist. Von Seiten der aktuellen
Therapiemöglichkeiten werden als Therapie der ersten Wahl Steroide, Immunglobuline
und Plasmapherese genannt. Mit Recht weisen die Autoren darauf hin, dass es
mittlerweile, was viele Patienten sehr begrüßen, da es sich um eine chronische
Erkrankung handelt, auch die Möglichkeit der subkutanen Immunglobulintherapie gibt.
Des Weiteren werden Immunsuppressiva, wie Azathioprin, Cyclophosphamid,
Mycophenolatmofetil und Rituximab diskutiert. Warnend möchte ich bezüglich des
Rituximab auf eigene Erfahrungen hinweisen, dass dies nur bei guter Dokumentation
(Hinweis auf off-label-use) von den Krankenkassen übernommen wird.
Homöopathie – Option im Sinne von Planetary Health
Authors: Riker Ulf 
Published: June 2024

ZusammenfassungDass der Klimawandel weitreichende Folgen für Mensch, Tier und Natur hat, ist nicht erst seit gestern bekannt. Wissenschaft, Politik und Wirtschaft haben es jedoch versäumt, geeignete Lösungen zu finden und umzusetzen. Dennoch kann jeder Einzelne selbstbestimmt und eigenverantwortlich allgemeine Maßnahmen im Alltag ergreifen. Das betrifft aber auch die Medizin und die Frage, wie man medizinisch behandelt werden möchte. Am Beispiel der Homöopathie zeigt der Beitrag, dass die Therapie nicht nur wirksam ist, sondern auch die Umwelt schont.
A Discount Approach to Reducing Nursing Alert Burden
Authors: Thompson Sarah A. , Kandaswamy Swaminathan , Orenstein Evan 
Published: June 2024

Abstract
Background Numerous programs have arisen to address interruptive clinical decision support (CDS) with the goals of reducing alert burden and alert fatigue. These programs often have standing committees with broad stakeholder representation, significant governance efforts, and substantial analyst hours to achieve reductions in alert burden which can be difficult for hospital systems to replicate.
Objective This study aimed to reduce nursing alert burden with a primary nurse informaticist and small support team through a quality-improvement approach focusing on high-volume alerts.
Methods Target alerts were identified from the period of January 2022 to April 2022 and four of the highest firing alerts were chosen initially, which accounted for 43% of all interruptive nursing alerts and an estimated 86 hours per month of time across all nurses occupied resolving these alerts per month. Work was done concurrently for each alert with design changes based on the Five Rights of CDS and following a quality-improvement framework. Priority for work was based on operational engagement for design review and approval. Once initial design changes were approved, alerts were taken for in situ usability testing and additional changes were made as needed. Final designs were presented to stakeholders for approval prior to implementation.
Results The total number of interruptive nursing alert firings decreased by 58% from preintervention period (1 January 2022–30 June 2022) to postintervention period (July 1, 2022–December 31, 2022). Action taken on alerts increased from 8.1 to 17.3%. The estimated time spent resolving interruptive alerts summed across all nurses in the system decreased from 197 hours/month to 114 hours/month.
Conclusion While CDS may improve use of evidence-based practices, implementation without a clear framework for evaluation and monitoring often results in alert burden and fatigue without clear benefits. An alert burden reduction effort spearheaded by a single empowered nurse informaticist efficiently reduced nursing alert burden substantially.
Availability and Opportunities for Expansion of Buprenorphine for the Treatment of Opioid Use Disorder
Authors: McKendrick Greer , Stull Samuel W. , Sharma Anjalee , Dunn Kelly E. 
Published: June 2024

AbstractThere is an urgent need to expand access to treatment for persons with opioid use disorder (OUD). As neurologists may frequently encounter patients with chronic pain who have developed OUD, they are in a position to serve as advocates for treatment. Buprenorphine is the most scalable medication for OUD in the United States, yet expansion has plateaued in recent years despite growing treatment needs. Reluctance of providers to establish treatment with new patients, challenges with rural expansion, stigma related to buprenorphine-based care, and pharmacy pressures that incentivize low dispensing and inventories may have stalled expansion. This review introduces these challenges before outlining actionable and evidenced-based strategies that warrant investigation, including methods to improve patient access to care (remotely delivered care, mobile delivery programs, Bridge programs) and provider retention and confidence in prescribing (expert consults, Extension for Community Healthcare Outcomes, a telementoring model, hub-and-spoke services), as well as novel innovations (virtual reality, artificial intelligence, wearable technologies). Overall, fortifying existing delivery systems while developing new transformative models may be necessary to achieve more optimal levels of buprenorphine treatment expansion.
Predictive Factors of Radioactive Iodine Therapy Refractoriness in Patients with Differentiated Thyroid Carcinoma
Authors: Bel Lakhdar Majdouline , Mouaden Ayat , Zekri Mourad , Alami Dounia , Zarouf Hamza , Ghfir Imad , Guerrouj Hasnae 
Published: June 2024

Abstract
Aim Differentiated thyroid carcinoma (DTC) is the most prevalent endocrine malignancy, with radioactive iodine (RAI) therapy being a standard of care. However, RAI refractoriness, occurring in a subset of patients, significantly impacts survival rates. Understanding predictive factors for RAI refractoriness is crucial for optimizing patient management.
Methods This retrospective study analyzed data from 90 DTC patients at Ibn Sina University Hospital, Morocco. Patients were categorized into RAI-refractory (RAIR) and non-RAIR groups based on established criteria. Statistical analyses, including univariate and multivariate logistic regression, were performed to identify predictive factors of RAI refractoriness.
Results Age at the time of diagnosis ≥ 54 years, primary tumor diameter ≥ 29 mm, and distal/nodal metastasis were independent predictors of RAIR-DTC. Additionally, the oncocytic carcinoma histological subtype significantly increased the risk of refractoriness. These findings were consistent with previous studies and underscored the importance of early detection and risk stratification.
Conclusion Recognition of predictive factors for RAI refractoriness, including age, tumor size, distal/nodal metastasis, and histological subtype, facilitates early identification of high-risk patients. This enables timely intervention and personalized treatment strategies, particularly relevant in resource-limited settings. Further prospective studies are warranted to validate these findings and explore additional molecular markers for improved prediction of RAI refractoriness.
Complimentary Role of [18F]FDG and [18F]NaF-PET/CT in Evaluating Synchronous Thyroid Carcinoma and Parathyroid Adenoma with Brown Tumors
Authors: Edamadaka Yeshwanth , Parghane Rahul V. , Basu Sandip 
Published: June 2024

AbstractWe herein present a patient initially suspected of multiple lytic skeletal metastasis of unknown primary on anatomical imaging. Metabolic imaging by [18F]-fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) detected focal [18F]FDG uptake in the right thyroid nodule, mild [18F]FDG uptake in soft tissue lesion in the left inferior parathyroid region, and multiple nonavid osteolytic skeletal lesions. Fine-needle aspiration cytology of the right thyroid nodule showed papillary thyroid carcinoma (PTC). The patient had raised serum parathyroid hormone and serum calcium levels, suggesting parathyroid disease. [18F]-sodium fluoride (NaF)-PET/CT showed a metabolic superscan pattern of hyperparathyroidism with brown tumors rather than metastatic lytic skeletal lesions. Patient underwent total thyroidectomy and bilateral central compartment clearance, along with soft tissue lesion resection in the left inferior parathyroid region. Finally, histopathology confirmed PTC classical variant with no aggressive histology features (pT1N0) for thyroid nodule and parathyroid adenoma for soft tissue lesion in the left inferior parathyroid region. The findings of the [18F]FDG and [18F]NaF-PET/CT imaging were helpful for making a final diagnosis of synchronous thyroid cancer and parathyroid adenoma, which in turn guided the appropriate treatment strategy.
Identifying colours in the absorption spectrum with an app
Authors: Machado Natalia Alves , Hahn Marcelo Dumas , Cruz Frederico Alan de Oliveira , Carvalho Paulo Simeão 
Published: June 2024

Abstract
This study addresses the challenges faced by students with colour blindness during the exploration of light spectra, emphasizing the crucial adaptation of educational materials for effective learning. The proposed solution, characterized by its low-cost and straightforward implementation, involves the use of smartphone apps, notably the ‘ColorADD,’ to assist students who cannot perceive colours in understanding spectral phenomena. This topic is integrated into the curricula of both high school and undergraduate physics courses in Portugal and Brazil. This approach represents a tangible opportunity to promote inclusive scientific education, fostering active participation and ensuring equal opportunities for colour-blind students without compromising their overall visual perception.
The design, circuit realization and applications of chaotic system with offset-boosting and multistability
Authors: Zhang Jie , Wang Pengyuan , Wang Xinghao , Cheng Nana 
Published: June 2024

Abstract
Based on the foundation of a three-dimensional Jerk chaotic system, a novel four-dimensional chaotic system based on a memristor with cosine magneto-memristor is proposed. The system’s dynamical behavior is analyzed using bifurcation diagrams, Lyapunov exponents, multiple bifurcation diagrams, two-parameter Lyapunov exponents, complexity, and attractor basins. It is found that this new chaotic system exhibits characteristics such as multistability, transient chaos, intermittent chaos, spike discharge, controllable multi-vortex, and offset-boosting. The chaotic system is designed and simulated in analog circuit and realized in a digital circuit using a Field-Programmable Gate Array (FPGA). The consistency between simulation results and implementation results demonstrates the existence and feasibility of the system. Finally, the significance and superiority of the control scheme are verified based on the adaptive anti-synchronization control strategy, and the synchronization strategy is applied to image encryption, and the results show that the encryption effect is excellent and the anti-jamming ability is strong.
Natural metric-affine inflation
Authors: Racioppi Antonio , Salvio Alberto 
Published: June 2024

AbstractWe consider here natural inflation in the low energy (two-derivative) metric-affine theory containing only the minimal degrees of freedom in the inflationary sector, i.e. the massless graviton and the pseudo-Nambu-Goldstone boson (PNGB). This theory contains the Ricci-like and parity-odd Holst invariants together with non-minimal couplings between the PNGB and the above-mentioned invariants. The Palatini and Einstein-Cartan realizations of natural inflation are particular cases of our construction. Explicit models of this type featuring non-minimal couplings are shown to emerge from the microscopic dynamics of a QCD-like theory with an either sub-Planckian or trans-Planckian confining scale and that is renormalizable on Minkowski spacetime. Moreover, for these models, we find regions of the parameter space where the inflationary predictions agree with the most recent observations at the 2σlevel. We find that in order to enter the 1σregion it is necessary (and sufficient) to have a finite value of the Barbero-Immirzi parameter and a sizable non-minimal coupling between the inflaton and the Holst invariant (with sign opposite to the Barbero-Immirzi parameter). Indeed, in this case the potential of the canonically normalized inflaton develops a plateau as shown analytically.
A search for AGN sources of the IceCube diffuse neutrino flux
Authors: McDonough K. , Hughes K. , Smith D. , Vieregg A.G. 
Published: June 2024

Abstract
The origin of the diffuse astrophysical neutrino flux measured by the IceCube Observatory remains largely unknown.
Although NGC 1068 and TXS 0506+056 have been identified as potential neutrino sources, the diffuse flux of neutrinos must have additional sources that have not yet been identified.
Here we investigate potential correlations between IceCube's neutrino events and the Fermi and MOJAVE source catalogs, using the publicly-available IceCube data set. We perform three separate spatially-dependent, energy-dependent, and time-dependent searches, and find no statistically significant sources outside of NGC 1068. We find that, under the most optimistic assumptions of a spectral index of 2.0 and a neutrino flux uncorrelated with the gamma ray flux, no more than 13% of IceCube's neutrino flux originates from blazars over the whole sky. Then, using an energy-dependent likelihood analysis, the limit on neutrinos originating from blazars reduces to 9% in the Northern hemisphere under the same spectral index and flux assumptions. Finally, we set limits on individual sources from the MOJAVE radio catalog after finding no statistically significant time-flaring sources.
Gravitational waves in a cyclic Universe: resilience through cycles and vacuum state
Authors: Angelis Mariaveronica De , Smith Adam , Giarè William , van de Bruck Carsten 
Published: June 2024

Abstract
We present a generalised calculation for the spectrum of primordial tensor perturbations in a cyclic Universe, making no assumptions about the vacuum state of the theory and accounting for the contribution of tensor modes produced in the dark energy phase of the previous cycle. We show that these modes have minimal impact on the spectrum observed in the current cycle, except for corrections on scales as large as the comoving Hubble radius today. These corrections are due to sub-horizon modes produced towards the end of the dark energy phase, persisting into the ekpyrotic phase of the next cycle as additional quanta. In relation to the vacuum state, we argue that non-Bunch-Davies quanta can easily overwhelm the energy density driving the dark energy phase, potentially compromising the model. Therefore, avoiding backreaction effects sets restrictive constraints on deviations away from the Bunch-Davies vacuum during this phase, limiting the overall freedom to consider alternative vacua in the cyclic Universe.
Ward identities under the frame transformations in curved space-time
Authors: Mandal Susobhan 
Published: June 2024

Abstract
Scalar-tensor theories of gravity are considered to be competitors to Einstein's theory of general relativity for the description of classical gravity, as they are used to build feasible models for cosmic inflation. These theories can be formulated both in the Jordan and Einstein frame, which are related by a Weyl transformation with a field transformation, known together as a frame transformation. These theories formulated in the above two frames are often considered to be equivalent from the point of view of classical theory. However, this is no longer true from the quantum field theoretical perspective. In the present article, we show that the Ward identities derived in the above two frames are not connected through the frame transformation. This shows that the quantum field theories formulated in these two frames are not equivalent to each other. Moreover, this inequivalence is also shown by comparing the effective actions derived in these two frames.
A 16-bit 18-MSPS flash-assisted SAR ADC with hybrid synchronous and asynchronous control logic
Authors: Ji Junyao , Ji Xinao , Zhou Ziyu , Dai Zhichao , Chen Xuhui , Zhang Jie , Jiang Zheng , Zhang Hong 
Published: June 2024

Abstract
This paper presents a 16-bit, 18-MSPS (million samples per second) flash-assisted successive-approximation-register (SAR) analog-to-digital converter (ADC) utilizing hybrid synchronous and asynchronous (HYSAS) timing control logic based on an on-chip delay-locked loop (DLL). The HYSAS scheme can provide a longer settling time for the capacitive digital-to-analog converter (CDAC) than the synchronous and asynchronous SAR ADC. Therefore, the issue of incomplete settling or ringing in the DAC voltage for cases of either on-chip or off-chip reference voltage can be solved to a large extent. In addition, the foreground calibration of the CDAC’s mismatch is performed with a finite-impulse-response bandpass filter (FIR-BPF) based least-mean-square (LMS) algorithm in an off-chip FPGA (field programmable gate array). Fabricated in 40-nm CMOS process, the prototype ADC achieves 94.02-dB spurious-free dynamic range (SFDR), and 75.98-dB signal-to-noise-and-distortion ratio (SNDR) for a 2.88-MHz input under 18-MSPS sampling rate.
An NMOS output-capacitorless low-dropout regulator with dynamic-strength event-driven charge pump
Authors: Xie Yiling , Wang Baochuang , Chen Dihu , Guo Jianping 
Published: June 2024

Abstract
In this paper, an NMOS output-capacitorless low-dropout regulator (OCL-LDO) featuring dual-loop regulation has been proposed, achieving fast transient response with low power consumption. An event-driven charge pump (CP) loop with the dynamic strength control (DSC), is proposed in this paper, which overcomes trade-offs inherent in conventional structures. The presented design addresses and resolves the large signal stability issue, which has been previously overlooked in the event-driven charge pump structure. This breakthrough allows for the full exploitation of the charge-pump structure's potential, particularly in enhancing transient recovery. Moreover, a dynamic error amplifier is utilized to attain precise regulation of the steady-state output voltage, leading to favorable static characteristics. A prototype chip has been fabricated in 65 nm CMOS technology. The measurement results show that the proposed OCL-LDO achieves a 410 nA low quiescent current (I
Q) and can recover within 30 ns under 200 mA/10 ns loading change.
A 28/56 Gb/s NRZ/PAM-4 dual-mode transceiver with 1/4 rate reconfigurable 4-tap FFE and half-rate slicer in a 28-nm CMOS
Authors: He Yukun , Yuan Zhao , Wang Kanan , Tang Renjie , He Yunxiang , Chen Xian , Ye Zhengyang , Gui Xiaoyan 
Published: June 2024

Abstract
A 28/56 Gb/s NRZ/PAM-4 dual-mode transceiver (TRx) designed in a 28-nm complementary metal-oxide-semiconductor (CMOS) process is presented in this article. A voltage-mode (VM) driver featuring a 4-tap reconfigurable feed-forward equalizer (FFE) is employed in the quarter-rate transmitter (TX). The half-rate receiver (RX) incorporates a continuous-time linear equalizer (CTLE), a 3-stage high-speed slicer with multi-clock-phase sampling, and a clock and data recovery (CDR). The experimental results show that the TRx operates at a maximum speed of 56 Gb/s with chip-on board (COB) assembly. The 28 Gb/s NRZ eye diagram shows a far-end vertical eye opening of 210 mV with an output amplitude of 351 mV single-ended and the 56 Gb/s PAM-4 eye diagram exhibits far-end eye opening of 33 mV (upper-eye), 31 mV (mid-eye), and 28 mV (lower-eye) with an output amplitude of 353 mV single-ended. The recovered 14 GHz clock from the RX exhibits random jitter (RJ) of 469 fs and deterministic jitter (DJ) of 8.76 ps. The 875 Mb/s de-multiplexed data features 593 ps horizontal eye opening with 32.02 ps RJ, at bit-error rate (BER) of 10−5 (0.53 UI). The power dissipation of TX and RX are 125 and 181.4 mW, respectively, from a 0.9-V supply.