bluuebunny/crossref_metadata_2025_split huggingface dataset:
Outcome of incidental versus preoperatively diagnosed colorectal cancer during total proctocolectomy with ileal pouch–anal anastomosis for inflammatory bowel disease
Authors: Maspero Marianna , Otero Ana , Lavryk Olga , Gorgun Emre , Lipman Jeremy , Liska David , Valente Michael , Holubar Stefan , Steele Scott R. , Hull Tracy 
Published: April 2024

AbstractAimTotal proctocolectomy with ileal pouch–anal anastomosis (IPAA) is the treatment of choice for colorectal cancer (CRC) in inflammatory bowel disease. CRC may also be discovered incidentally at IPAA for other indications. We sought to determine whether incidentally found CRC at IPAA was associated with worse outcomes.MethodsOur institutional pouch registry (1983–2021) was retrospectively reviewed. Patients with CRC at pathology after IPAA were divided into two groups: a preoperative diagnosis (PreD) group and an incidental diagnosis (InD) group. Their long‐term outcomes (overall survival, disease‐free survival and pouch survival) were compared.ResultsWe included 164 patients: 53 (32%) InD and 111 (68%) PreD. There were no differences in cancer staging, differentiation and location. After a median follow‐up of 11 (IQR 3–25) years for InD and 9 (IQR 3–20) years for the PreD group, deaths were 14 (26%) in the InD group and 18 (16%) in the PreD group. Pouch failures were five (9%) in the InD group and nine (8%) in the PreD group, of which two (5%) and four (4%) were cancer related. Ten‐year overall survival was 94% for InD and 89% for PreD (P = 0.41), disease‐free survival was 95% for InD and 90% for PreD (P = 0.685) and pouch survival was 89% for InD and 97% for PreD (P = 0.80). Pouch survival at 10 years was lower in rectal versus colon cancer (87% vs. 97%, P = 0.01). No difference was found in outcomes in handsewn versus stapled anastomoses.ConclusionInflammatory bowel disease patients with incidentally found CRC during IPAA appear to have similarly excellent oncological and pouch outcomes to patients with a preoperative cancer diagnosis.
Biotransformation and disposition characteristics of HSK7653, a novel long‐acting dipeptidyl peptidase‐4 inhibitor for the treatment of type 2 diabetes
Authors: Bian Yi‐cong , Meng Jian , Hu Tao , Ma Sheng , Huang Chen‐rong , Zhang Feng‐yi , Wu Qing‐he , Zhang Hua , Chen Xiao‐yan , Miao Li‐yan 
Published: April 2024

AbstractAimTo investigate the metabolism and disposition characteristics of HSK7653 in healthy male Chinese participants.MethodsA single oral dose of 80 μCi (25 mg) [14C]HSK7653 capsules was administered to six healthy participants, and blood, plasma, urine and faeces were collected. Quantitative and qualitative analysis was conducted to investigate the pharmacokinetics, blood‐to‐plasma ratio, mass balance and metabolism of HSK7653.ResultsThe drug was well absorbed and reached a maximum concentration at 1.25 h. The drug‐related components (HSK7653 and its metabolites) were eliminated slowly, with a half‐life (t1/2) of 111 h. Unchanged HSK7653 contributed to more than 97% of the total radioactivity in all plasma samples. The blood‐to‐plasma ratio (0.573‐0.845) indicated that HSK7653 did not tend to distribute into blood cells. At 504 h postdose, up to 95.9% of the dose was excreted, including 79.8% in urine and 16.1% in faeces. Most of the radioactivity (75.5% dose) in excreta was unchanged HSK7653. In addition, nine metabolites were detected in urine and faeces. The most abundant metabolite was M6‐2, a dioxidation product of HSK7653, which accounted for 4.73% and 2.63% of the dose in urine and faeces, respectively. The main metabolic pathways of HSK7653 in vivo included oxidation, pyrrole ring opening and sulphonamide hydrolysation.ConclusionHSK7653 was well absorbed, slightly metabolized and slowly excreted in humans. The high plasma exposure and long t1/2 of HSK7653 may contribute to its long‐lasting efficacy as a long‐acting dipeptidyl peptidase‐4 inhibitor.
The effect of animated movies on speaking skills among motivated English foreign language learners: Elementary level
Authors: Wang Rong , Do Dange Mustafa , Izadpanah Siros 
Published: April 2024

AbstractTechnology has become an integral part of our daily lives, permeating every aspect. One area where technology has shown potential to enhance English as a Foreign Language (EFL) learning is through the use of animated movies. Despite the growing significance of technology in education, research is scarce in this specific area. Therefore, the aim of this study, conducted in 2023, was to investigate the impact of animated movies on the development of speaking abilities among motivated EFL learners. A total of 370 elementary students studying EFL in various institutions participated by responding to questionnaires. A multiple‐stage cluster sampling approach was employed to select the participants. The students were divided into two groups: the experimental group (EG) and the control group (CG). The selection of 15 animated films from a pool of 50 was performed using the Lawsh CVR (content validity ratio) and CVI (content validity index) algorithms, following validation by professionals. The study was designed as an experiment, and descriptive statistics and the ANCOVA test were employed to analyse the quantitative data. The findings revealed a significant difference between the pre‐test and post‐test results of the EG in English‐speaking skills, vocabulary learning, English pronunciation skills, understanding and recognition. According to the study, animated movies have the potential to aid teachers and EFL students in enhancing their speaking skills. This research sheds light on the benefits of incorporating animated movies into language learning environments, offering valuable insights for both educators and learners alike.
Living Beyond Restriction: LBR promotes cellular immortalization by suppressing genomic instability and senescence
Authors: Choi Haebeen , Kang Chanhee 
Published: April 2024

Cellular immortalization is a complex process that requires multiple genetic alterations to overcome restricting barriers, including senescence. Not surprisingly, many of these alterations are associated with cancer; two tumor suppressor pathways, the cellular tumor antigen p53 and p16‐Retinoblastoma (RB) pathways, are the best‐characterized examples, but their mutations alone are known to be insufficient to drive full immortalization. En et al. identified a role for the lamin B receptor (LBR) in promoting cellular proliferation and immortalization in p53‐ and RB‐deficient cells by maintaining their genome integrity and suppressing senescence. Thus, modulation of LBR could be exploited to treat cancer and potentially also to promote cell rejuvenation.
Microstructure degradation and residual low cycle fatigue life of a serviced turbine blade
Authors: Tan L. , Yang X. G. , Sun Y. T. , Shi D. Q. , Hao W. Q. , Zhang C. , Fu Z. Z. , Ji P. F. , Fan Y. S. 
Published: April 2024

AbstractThis paper was attempted to investigate the microstructure degradation and low cycle fatigue (LCF) performance of a serviced K465 Ni‐based superalloy turbine blade. LCF tests were carried out with small‐scale plate specimens sampled from the blades. Relationship between residual LCF life and microstructure state was estimated. The results indicate that the coarsening of γ/γ′ phases was the most significant microstructure degradation mode for the serviced blades. Both the γ matrix width and the γ′ precipitate diameter increased with the increase of service duration, while the γ′ precipitate volume fraction slightly decreased. The most severe microstructure degradation occurred at the leading edge along the chord direction, particularly at 50–70 % airfoil spans. The residual LCF life exhibited an accelerated decrease characteristic as increases of microstructure degradation degree. The coarsened microstructure diminished shear resistance of the superalloy, which resulted in additional accumulated inelastic deformation and a corresponding reduction in LCF life.
Association between migraine and exclusive breastfeeding: A cross‐sectional study
Authors: Vyas Manav V. , Lee Nathan , Lay Christine 
Published: April 2024

AbstractBackgroundMedical conditions may preclude a mother from exclusively breastfeeding her infant; however, the association between migraine and the duration of exclusive breastfeeding is not well known.ObjectiveTo evaluate the association between migraine and the duration of exclusive breastfeeding in a representative sample of Canadian females.MethodsWe used the Canadian Community Health Survey, a cross‐sectional survey, to identify females aged 20–49 years who delivered a baby in the previous 5 years. History of migraine was self‐reported. Females reported if they breastfed their baby, and among those who did, they further reported the duration of exclusive breastfeeding. We evaluated the association between migraine and the rate of breastfeeding, and the duration of exclusive breastfeeding adjusting for selected covariates.ResultsWe included 5282 females, of whom 862 (16.3%) had migraine. Compared to females without migraine, females with migraine were less likely to have high income (annual income >$80,000: 362 [42.0] vs. 2276 [51.6]), and more likely to have comorbid mood (176 [20.5] vs. 378 [8.6%]) and anxiety (196 [22.8%] vs. 406 [9.2%]) disorders. Migraine was not associated with breastfeeding (proportion of females who did not breastfeed, migraine vs. no migraine: 114/862 [13.2%] vs. 498/4420 [11.3%]; adjusted odds ratio 1.03; 0.74–1.27); however, females with migraine had lower odds (≥6 months of exclusive breastfeeding: 216/688 [31.4%] vs. 1325/3561 [37.2%]; adjusted odds ratio from ordinal shift analyses 0.84; 0.71–0.99) of longer duration of exclusive breastfeeding than females without migraine.ConclusionFemales with migraine exclusively breastfeed their infants for a shorter duration compared to females without migraine, suggesting the need to better support this population through education on the safety and benefits of exclusive breastfeeding and better access to safe and effective treatment of migraine in lactating females.
Publishing in premier journals with high impact factor and Q1 journals: Dos and Don'ts
Authors: Paul Justin 
Published: April 2024

AbstractThe evolving landscape of the academic world has ushered in a plethora of challenges and opportunities for researchers. While there are undoubtedly monetary incentives and fringe benefits for those who actively engage in publishing, the journey toward acceptance by a premier journal is often arduous and time‐consuming. Considering this context, this paper endeavors to dissect prevailing trends, elucidate the reasons behind manuscript rejections, and furnish a compendium of strategies and insights aimed at augmenting the likelihood of acceptance while mitigating the probability of rejection.
Inoculated fermentation of cv. Conservolea natural black olives with multifunctional starter cultures in reduced‐sodium brines
Authors: Tzamourani Aikaterini , Kalogri Georgia , Kavvatha Maria , Kochila Aggeliki , Manthou Evanthia , Liu Yangtai , Panagou Efstathios Z. 
Published: April 2024

SummaryThe purpose of this research was to investigate the fermentation of Conservolea variety natural black olives using two lactic acid bacteria (LAB) with multifunctional potential as starter cultures. Moreover, the effect of 50% substitution of NaCl by KCl in the brines was examined to produce a reduced‐sodium product with multifunctional potential. For this purpose, Lactiplantibacillus pentosus B363 and Lactiplantibacillus plantarum B380, previously isolated from table olive fermentations and characterised for technological and probiotic potential, were inoculated at the onset of fermentation in 6% (w/v) NaCl and 3% (w/v) NaCl/3% (w/v) KCl salt brines. The microbial populations (LAB, yeasts, and Enterobacteriaceae), pH, acidity, salt content, organic acids, and ethanol were measured in the brine for 146 days. Additionally, the recovery of each starter culture from the olive drupes at the beginning (5 days) and final (146 days) stages of fermentation was determined by plating, genotyping, and identification through RAPD‐PCR and 16S region amplicon sequencing, respectively, and subsequent strain differentiation through rep‐GTG5 fingerprint analysis. The results revealed the dominance of LAB in populations from 5.5 to 8.1 log CFU/mL. The final recovery rate of L. pentosus B363 on the olives was approximately 80% in both 6% (w/v) NaCl and reduced (3% (w/v) NaCl/3% (w/v) KCl) salt brines. Similarly, L. plantarum B380 recovery rates were 89% and 85%, respectively, for the same fermentations. Yeasts coexisted with LAB in counts ranging from 2.3 to 5.8 log CFU/mL, whereas no enterobacteria were enumerated in the brines and olives at the end of fermentation. The obtained fermentation profile and the sensory analysis of the olives revealed a typical lactic acid fermentation in both control and reduced‐sodium brines. The current results support the feasibility of the production of reduced‐sodium natural black olives with probiotic potential. The proposed fermentation process, including the selected starters, can be readily employed by the table olive industry to meet consumers' needs for low‐sodium dietary intake while enhancing the functional potential of table olives.
An engineering approach to the 3D printing of K‐Carrageenan/konjac glucomannan hydrogels
Authors: Russo Spena Simona , Visone Biagio , Grizzuti Nino 
Published: April 2024

SummaryAqueous solutions of Konjac glucomannan (KGM)/κ‐Carrageenan (κ‐C) of different ratios (1:2, 1:5, 1:8 and 1:10) and a fixed κ‐C content of 1.5%, were proposed as a new 3D food printing ink. Their thermo‐responsive behaviour was evaluated by temperature ramp rheological tests. This characterisation allowed for the evaluation of the synergistic effect between KGM and κ‐C and gave indications useful to the printing performance. Both elastic (G′) and loss (G″) moduli were found to increase by increasing the KGM concentration. Samples were printed by controlling the thermally reversible sol/gel transition occurring during the process. Direct pressure and flow rate measurements in the 3D printer were used to obtain the viscosity versus shear rate curves under processing conditions, useful to validate a scaling law relating the printing filament diameter to the relevant process and material properties (inks viscosity and printing pressure). The 3D printing performance of inks was evaluated by means of a novel, integrated score system. The results obtained indicate that aqueous mixtures of KGM/κ‐C can be successfully employed as a base for 3D printing food hydrogels. The use of the score system above outlined proved to be an easy yet efficient tool for the optimisation of the gel composition.
Rating accuracy, leniency, and rater perceptions when using the RPM and BARS
Authors: Feeney Justin R. , Daljeet Kabir N. , Goffin Richard D. , Schneider Travis J. 
Published: April 2024

AbstractResearchers have argued that social‐comparative rating formats hold important psychometric advantages over traditional absolute ratings. We asked 152 participants to observe and assess the videotaped performance of individuals completing a task using a social‐comparative (Relative Percentile Method; RPM) and absolute rating (Behaviorally Anchored Rating Scale; BARS) formats. After collecting expert ratings on the same set of videos, we calculated accuracy indices and leniency. Additionally, we collected rater perceptions of accuracy and fairness for both formats. Our study revealed that the BARS was perceived as more accurate and fairer than the RPM. However, the RPM was found to be better at combating rater leniency. We discuss the implications of these findings.
Ethnographic perspectives of mothers and professionals on including children with disabilities in oral health in the Kingdom of Saudi Arabia
Authors: Alwadi Maram Ali M. , Baker Sarah R. , Owens Janine 
Published: April 2024

AbstractBackgroundChildren with disabilities generally face poorer oral health outcomes compared with their non‐disabled peers due to a range of factors including inadequate oral hygiene, infrequent dental visits and systemic barriers in accessing care.AimThis ethnographic study explored the perspectives of caregivers and professionals to identify the ways that children with disabilities are included in oral health.DesignA purposive sample of 10 caregivers, all mothers with disabled children aged 9–15 years, five healthcare providers and five educators in Saudi Arabia, participated. Data collection used participant observation and semi‐structured in‐depth interviews. Data were analysed using reflexive thematic analysis.ResultsThe findings suggest that mothers lacked a supportive environment to develop their skills and knowledge about oral health care, preventing them from including their children in oral health. Inaccessible services added to the exclusion of both mothers and children. Some dental professionals exhibited poor communication skills and discriminatory attitudes towards the children and problematising mothers. Educators tended to discuss disabled children in terms of inability, displaying a deficit approach to impairment.ConclusionsThe evidence suggests the exclusion of mothers from oral health. This has an impact on how they enable their children. Recommendations include adopting a social model of disability in dental education and policies in Saudi Arabia to address inequalities. Provision of support, education and focusing on societal barriers moves towards inclusion rather than conceptualising disability as an individual problem.
Which dimensions of culture matter for central bank independence? International evidence
Authors: Fang Tong 
Published: April 2024

AbstractIn this paper, we examine the relationship between Hofstede national cultures and de jure central bank independence. We propose theoretical hypotheses to explain how cultural dimensions determine central bank independence and test these hypotheses using an international dataset. We find that two cultural dimensions, namely, individualism and uncertainty avoidance, are significantly related to central bank independence. Central bank independence is higher in collectivistic and uncertainty avoidance countries. We further reveal that these cultural dimensions affect central bank independence in different ways. Individualism and uncertainty avoidance are related to independence in policy formulation and limitations on lending to governments. Although power distance and masculinity are insignificantly related to total central bank independence, they affect independence in objectives, policy formulation and limitation on lending to governments. Our results are robust through a series of checks.
Target setting for airlines: A DEA bargaining approach with network structure
Authors: Yu Ming‐Miin , Rakshit Ipsita 
Published: April 2024

AbstractThe objective of this study is to find out how airlines can reduce their inputs and provide appropriate passenger and cargo capacity, thereby increasing passenger and cargo traffic and reducing CO2 emissions. A network data envelopment analysis (DEA)–based Nash bargaining model is developed incorporating intermediate products and weakly disposable undesirable outputs and is applied to a dataset of 33 airline companies to obtain the bargaining solution. According to the results, airlines that are weak efficient or inefficient could establish their targets to attain efficiency through a fair and logical negotiation among the inputs, intermediate products, good outputs and bad output. Appropriate policies need to be implemented that would improve the airlines’ performance in terms of improvement in not only the efficiency of inputs and desirable outputs along with intermediate products but also with regard to environmental performance. This would ensure sustainable growth in airlines’ performance.
A facile route for decoration of hematite photoanodes by transition metal hydroxide co‐catalysts
Authors: Dadashi Radvar Sahand , Yourdkhani Amin , Poursalehi Reza 
Published: April 2024

AbstractEarth‐abundant α‐Fe2O3 (hematite) is a convincing photoanode for photoelectrochemical (PEC) water splitting; however, its intrinsic properties of inferior charge transfer and sluggish water oxidation kinetics limit its performance. Here, we report a straightforward decoration method for transition metal hydroxides to accelerate the oxygen evolution reaction (OER) of hematite photoanodes grown by electric field‐assisted liquid phase deposition (EA‐LPD). The investigations revealed that Co(OH)2 acts as a superior co‐catalyst compared with hydroxides of Mn, Fe, Co, Ni, and Zn. EA‐LPD‐grown hematite photoanode loaded with cobalt hydroxide exhibited an excellent PEC performance. A photocurrent density of 0.93 mA.cm−2 at 1.23 V versus reversible hydrogen electrode was achieved for the modified hematite, ∼3 times more than that of pristine hematite, and a cathodic shift of 100 mV for the onset potential was observed. The proposed simple and cost‐effective co‐catalyst loading strategy provides a high degree of freedom in the design of co‐catalysts with a complex chemical composition comprising transition metal oxyhydroxides and hydroxides on different photoanodes for more efficient charge carrier separation for the PEC applications.
First‐line managers' experience of guideline implementation during the COVID‐19 pandemic
Authors: Fjordkvist Erika , Eldh Ann Catrine , Winberg Madeleine , Joelsson‐Alm Eva , Hälleberg Nyman Maria 
Published: April 2024

AbstractAim(s)To explore first‐line managers' experience of guideline implementation in orthopaedic care during the COVID‐19 pandemic.DesignA descriptive, qualitative study.MethodsSemi‐structured interviews with 30 first‐line nursing and rehabilitation managers in orthopaedic healthcare at university, regional and local hospitals. The interviews were analysed by thematic analysis.ResultsFirst‐line managers described the implementation of guidelines related to the pandemic as different from everyday knowledge translation, with a swifter uptake and time freed from routine meetings in order to support staff in adoption and adherence. The urgent need to address the crisis facilitated guideline implementation, even though there were specific pandemic‐related barriers such as staffing and communication issues. An overarching theme, Hanging on to guidelines for dear life, is substantiated by three themes: Adapting to facilitate change, Anchoring safety through guidelines and Embracing COVID guidelines.ConclusionA health crisis such as the COVID‐19 pandemic can generate enabling elements for guideline implementation in healthcare, despite prevailing or new hindering components. The experience of guideline implementation during the COVID‐19 pandemic can improve understanding of context aspects that can benefit organizations in everyday translation of evidence into practice.Implications for the Profession and/or Patient CareRecognizing what enabled guideline implementation in a health crisis can help first‐line managers to identify local enabling context elements and processes. This can facilitate future guideline implementation.ImpactDuring the COVID‐19 pandemic, the healthcare context and staff's motivation for guideline recognition and adoption changed. Resources and ways to bridge barriers in guideline implementation emerged, although specific challenges arose. Nursing managers can draw on experiences from the COVID‐19 pandemic to support implementation of new evidence‐based practices in the future.Reporting MethodThis study adheres to the EQUATOR guidelines by using Standards for Reporting Qualitative Research (SRQR).No Patient or Public Contribution.