bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cost implications of new treatments for advanced colorectal cancer
Authors: Wong Yu‐Ning , Meropol Neal J. , Speier William , Sargent Daniel , Goldberg Richard M. , Beck J. Robert 
Published: March 2009

AbstractBACKGROUND:Since 1996, 6 new drugs have been introduced for the treatment of metastatic colorectal cancer. Although they are promising, these drugs frequently are given in the palliative and are much more expensive than older treatments. The objective of the current study was to measure the cost implications of treatment with sequential regimens that include chemotherapy and/or monoclonal antibodies.METHODS:A Markov model was used to evaluate a hypothetical cohort of 1000 patients with newly diagnosed, metastatic colorectal cancer. Patients supposedly received up to 3 lines of treatment before supportive care and subsequent death. Data were obtained from published, multicenter phase 2 and randomized phase 3 clinical trials. Sensitivity analyses were conducted on the efficacy, toxicity, and cost.RESULTS:Using drug costs alone, treatment that included new chemotherapeutic agents increased survival at an incremental cost‐effectiveness ratio (ICER) of $100,000 per discounted life‐year (DLY). The addition of monoclonal antibodies improved survival at an ICER of >$170,000 per DLY. The results were most sensitive to changes in the initial regimen. Even with significant improvements in clinical characteristics (efficacy and toxicity), treatment with the most effective regimens still had very high ICERs.CONCLUSIONS:Treatment of metastatic colorectal cancer with the most effective regimens came at very high incremental costs. The authors concluded that cost‐effectiveness analyses should be a routine component of the drug‐development process, so that physicians and patients are informed appropriately regarding the value of new innovations. Cancer 2009. © 2009 American Cancer Society.
Lymph node ratio predicts disease‐specific survival in melanoma patients
Authors: Xing Yan , Badgwell Brian D. , Ross Merrick I. , Gershenwald Jeffrey E. , Lee Jeffrey E. , Mansfield Paul F. , Lucci Anthony , Cormier Janice N. 
Published: March 2009

AbstractBACKGROUND:The objectives of this analysis were to compare various measures associated with lymph node (LN) dissection and to identify threshold values associated with disease‐specific survival (DSS) outcomes in patients with melanoma.METHODS:Patients with lymph node‐positive melanoma who underwent therapeutic LN dissection of the neck, axilla, and inguinal region were identified from the SEER database (1988‐2005). We performed Cox multivariate analyses to determine the impact of the total number of LNs removed, number of negative LNs removed, and LN ratio on DSS. Multivariate cut‐point analyses were conducted for each anatomic region to identify the threshold values associated with the largest improvement in DSS.RESULTS:The LN ratio was significantly associated with DSS for all LN regions. The LN ratio thresholds resulting in the greatest difference in 5‐year DSS were .07, .13, and .18 for neck, axillary, and inguinal regions, respectively, corresponding to 15, 8, and 6 LNs removed per positive lymph node. After adjustment for other clinicopathologic factors, the hazard ratios (HRs) were .53 (95% confidence interval [CI], .40 to .71) in the neck, .52 (95% CI, .42 to .65) in the axillary, and .47 (95% CI, .36 to .61) in the inguinal regions for patients who met the LN ratio threshold.CONCLUSIONS:Among the prognostic factors examined, LN ratio was the best indicator of the extent of LN dissection, regardless of anatomic nodal region. These data provide evidence‐based guidelines for defining adequate LN dissections in melanoma patients. Cancer 2009. © 2009 American Cancer Society.
Radical nephrectomy surgical outcomes in the University HealthSystem Consortium Data Base
Authors: Mitchell Robert E. , Lee Byron T. , Cookson Michael S. , Barocas Daniel A. , Duke Herrell S. , Clark Peter E. , Smith Joseph A. , Chang Sam S. 
Published: March 2009

AbstractBACKGROUND:We sought to determine the impact of radical nephrectomy case volume, hospital size, and geographic region on immediate surgical outcomes for patients undergoing radical nephrectomy in academic centers across the country.METHODS:The University HealthSystem Consortium (UHC) Clinical Data Base was queried for data corresponding to patients who underwent radical nephrectomy at 1 of 134 academic medical centers nationwide between 2003 and quarter 2 of 2007 (n = 42,988). Radical nephrectomy case volume (1‐99, 100‐499, and 500 + ), total discharges (1‐49,999, 50,000‐99,999, 100,000 + ), and geographic region (5 categories) were determined for each academic center. ANOVA and the Tukey statistic were used. Length of stay, intensive care unit (ICU) rate, complication (comp) rate, and in‐hospital mortality were analyzed.RESULTS:Case volume was a significant predictor of length of stay, ICU, and comp. Mean length of stay was 6.88, 5.61, and 4.76 days, respectively, for centers from lowest to highest case volumes (P < .001). ICU rates for the 3 tiers were 30.77, 17.93, and 12.22 (P < .001). Comp rates were 24.50, 19.40, and 15.48 (P < .001). Tukey analysis revealed a ceiling effect: No differences were seen between the 2 higher case volume groups. Stratification by total discharges revealed differences in ICU rates (P = .001) and comp rates (P = .001). Region of the country had no significant impact on any of the outcome variables in this study.CONCLUSIONS:Radical nephrectomy case volume emerged as an important variable in predicting 3 of the 4 outcome parameters in this study. Results suggest that a “critical volume” of cases portends improved surgical outcomes. Cancer 2009. © 2009 American Cancer Society.
Molar Mass, Radius of Gyration and Second Virial Coefficient from new Static Light Scattering Equations for Dilute Solutions: Application to 21 (Macro)molecules
Authors: Illien Bertrand , Ying Ruifeng 
Published: March 2009

AbstractNew equations for static light scattering of dilute binary solutions allow molar mass determination of macromolecules from measurements of scattered intensity ratios between solution and solvent (Ir). In contrast to the standard Carr–Zimm equations, they do not rely on the experimental absolute value of the Rayleigh ratio of a reference liquid. The picture shows a typical plot for the surfactant BRIJ72 in CH2Cl2 (MSupplier=0.359 kg mol−1).magnified imageNew static light scattering (SLS) equations for dilute binary solutions are derived. Contrarily to the usual SLS equations [Carr–Zimm (CZ)], the new equations have no need for the experimental absolute Rayleigh ratio of a reference liquid and solely rely on the ratio of scattered intensities of solutions and solvent. The new equations, which are based on polarizability equations, take into account the usual refractive index increment ∂n/∂ρ2 complemented by the solvent specific polarizability and a term proportional to the slope of the solution density ρ versus the solute mass concentration ρ2 (density increment). Then all the equations are applied to 21 (macro)molecules with a wide range of molar mass (0.2<M<8000 kg mol−1). On the studied dataset with M<200 kg mol−1, the new equations clearly achieve a better agreement with supplier M values. For macromolecules (M>500 kg mol−1), for which the scattered intensity is no longer independent of the scattering angle, the new equations give the same value of the radius of gyration as the CZ equation and consistent values of the second virial coefficient.
Dynamic and Structural Properties of Aqueous Arsenic Solutions
Authors: Coskuner Orkid , Allison Thomas C. 
Published: March 2009

AbstractAqueous arsenic solutions are important in geochemistry, environmental chemistry, and biochemistry. Thus, studies of arsenic solutions that probe the structure of the hydrated arsenic ion and the behavior of water around As ions have wide‐ranging implications. The mechanisms for water dissociation around three arsenic ions (see picture) and structural details of the resulting aqueous complexes are presented.magnified image
Photoelectrochemical Studies of Gold Electrodes Chemically Modified with Single‐Walled Carbon Nanotubes
Authors: Merli Daniele , Profumo Antonella , Dondi Daniele , Albini Angelo 
Published: March 2009

AbstractSeeing the light: An electrode is assembled by linking acid‐shortened single‐walled carbon nanotubes with carboxylic groups to a gold surface modified with a cysteamine monolayer. The electrode generates a photocurrent when illuminated with visible light in the presence of an electroactive species (see picture). With an appropriate applied potential the device behaves as a photodiode.magnified imageThe preparation, characterization and unique photoelectrochemical characteristics of a gold electrode chemically modified with suitably derivatized single‐walled carbon nanotubes (SWCNTs) are described. The SWCNT–chemically modified gold electrode (CNT‐CME) is assembled by linking acid‐shortened SWCNTs with carboxylic groups at the nanotube ends to a gold surface previously modified with a cysteamine monolayer. A persistent photocurrent is observed when the modified electrode is illuminated with visible light in the presence of an electroactive species (ascorbic acid, AsA). The influence of physical variables (applied potential, light intensity) and of chemical parameters (AsA concentration, pH) on the generated photocurrents is evaluated. With an appropriate applied potential this device behaves as a photodiode.
Dispersed Fluorescence and Delayed Ionization of Jet‐Cooled 2‐Aminopurine: Relaxation to a Dark State Causes Weak Fluorescence
Authors: Feng Ke , Engler Gernot , Seefeld Kai , Kleinermanns Karl 
Published: March 2009

AbstractDark state: The photophysics of 9H‐2AP (see figure) depends strongly on the solvent and the temperature. In polar, aprotic solvents the fluorescence quantum yield is lower compared to protic ones. Analysis of the diffuse fluorescence spectra point to the existence of a dark singlet n,pi* state which is long‐lived (1 microsecond).magnified image
Salinophagia in anorexia nervosa: Case reports
Authors: Morgan John F. , Ahene Patience , Lacey J. Hubert 
Published: March 2009

AbstractWe report two cases of pathological ingestion of salt as a feature of anorexia nervosa, which we have previously termed “salinophagia.” Both cases were young women with anorexia nervosa of the purging subtype and of sufficient severity to necessitate inpatient treatment. In both instances, excessive quantities of salt were ingested in the context of treatment programs requiring nutritional rehabilitation, and motivated by a wish to despoil the food and render it distasteful, to rob its ingestion of any hedonic qualities. In one instance, this behavior pattern was imitated by other patients on the unit. Having first briefly described salinophagia in 1999, the first author has received considerable correspondence from other specialists suggesting that this is not an isolated phenomenon. The issues of phenomenology and treatment are further discussed. © 2009 by Wiley Periodicals, Inc. Int J Eat Disord, 2010
Validity and reliability of a Fijian translation and adaptation of the Eating Disorder Examination Questionnaire
Authors: Becker Anne E. , Thomas Jennifer J. , Bainivualiku Asenaca , Richards Lauren , Navara Kesaia , Roberts Andrea L. , Gilman Stephen E. , Striegel‐Moore Ruth H. 
Published: March 2009

AbstractObjective:Assessment of disordered eating has uncertain validity across culturally diverse populations. This study evaluated Eating Disorder Examination Questionnaire (EDE‐Q) performance in an ethnic Fijian study population.Method:The EDE‐Q was translated, adapted, and administered to school‐going Fijian adolescent females (N = 523). A subsample (n = 81) completed it again within ∼1 week. We assessed feasibility, internal consistency, and test‐retest reliability; evaluated construct validity through factor analysis and correlation with similar constructs; and examined the marginal utility of an additional question on traditional purgative use.Results:Internal consistency reliability was adequate for the global scale and subscales (Cronbach's alpha = 0.66–0.91); retest reliability was adequate for both the languages (range of ICCs, 0.50–0.79, and of kappas, 0.46–0.81, excluding purging items). Construct validity was supported by significant correlations with measures of similar constructs. Factor analysis confirms multiple dimensions of eating disorder symptoms but suggests possible culture‐specific variation in this population. The majority of respondents endorsing traditional purgative use (58%) did not endorse conventional EDE‐Q items assessing purging.Discussion:The EDE‐Q is a valid measure of eating disorder pathology for ethnic Fijian adolescent females and measures a unitary underlying construct. © 2009 by Wiley Periodicals, Inc. Int J Eat Disord, 2010
Restoration of degraded moving image for predicting a moving object
Authors: Akiyama Kei , Luo Zhi‐Wei , Onishi Masaki , Hosoe Shigeyuki 
Published: March 2009

AbstractIterative optimal calculation methods have been proposed for degraded static image restoration based on the multiresolution wavelet decomposition. However, it is quite difficult to apply these methods to process moving images due to the high computational cost. In this paper, we propose an effective restoration method for degraded moving images by modeling the motion of moving object and predicting the future object position. We verified our method by computer simulations and experiments to show that our method can achieve favorable results. © 2009 Wiley Periodicals, Inc. Electron Comm Jpn, 92(2): 38–48, 2009; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/ecj.10013
Information filtering with extracted index words using ICA
Authors: Yokoi Takeru , Yanagimoto Hidekazu , Omatu Sigeru 
Published: March 2009

AbstractWe propose an information filtering system with extracted index words using Independent Component Analysis (ICA). Elements of a document vector are established as the weights of index words and their dimensions become larger as the number of documents is increased. Therefore, from the viewpoint of processing time and memory space, the dimension must be decreased. The proposed method decreases the dimension by selecting the index words based on the topics included in the corpus. We have applied ICA to the documents to obtain the topics. Then filtering by the relevance feedback with the document vectors reconstructed by the selected index words, was carried out to confirm the effectiveness of the proposed method. © 2009 Wiley Periodicals, Inc. Electron Comm Jpn, 92(2): 21–27, 2009; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/ecj.10018
Synthesis and Characterization of Two New fac‐Tricarbonylrhenium(I) Biscarbene Complexes
Authors: Hiltner Oliver , Herdtweck Eberhardt , Drees Markus , Herrmann Wolfgang A. , Kühn Fritz E. 
Published: March 2009

Abstractfac‐Bromidotricarbonylbis(1,3‐diisopropylimidazoline‐2‐ylidene)rhenium(I) (4a) and fac‐bromidotricarbonylbis(1,3‐dicyclohexylimidazoline‐2‐ylidene)rhenium(I) (4b) with two coordinated 1,3‐dialkylsubstituted imidazoline‐2‐ylidenes were obtained by deprotonation of the corresponding imidazolium chloride salts. In this reaction two coordinated bromides of the metal precursor [NEt4]2[ReBr3(CO)3] were substituted by 1,3‐di‐R‐imidazoline‐2‐ylidene (R = iPr, Cy) ligands to generate two stable rhenium(I) biscarbene complexes that have similar structures, as proven by X‐ray diffraction and DFT calculations.(© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2009)
[Pd(NHC)(allyl)Cl] Complexes: Synthesis and Determination of the NHC Percent Buried Volume (%Vbur) Steric Parameter
Authors: Clavier Hervé , Correa Andrea , Cavallo Luigi , Escudero‐Adán Eduardo C. , Benet‐Buchholz Jordi , Slawin Alexandra M. Z. , Nolan Steven P. 
Published: March 2009

AbstractComplexes of palladium bearing NHC ligands (NHC=N‐heterocyclic carbene) were synthesized and fully characterized. The [Pd(NHC)(allyl)Cl] series was obtained by simple cleavage of [Pd(allyl)Cl]2 by using either the isolated free NHC or the in situ generated NHC. The NHC ligand sterics were varied by introduction of groups attached to the C4–C5 carbon atoms of the NHC backbone. Results of the X‐ray diffraction study permitted determination of the NHC steric parameters within this series. It was observed that the NHC backbone induces variations in its percent buried volume (%Vbur) as a function of the N‐substituents.(© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2009)
United we stand: Intergroup conflict moderates the intergroup sensitivity effect
Authors: Ariyanto Amarina , Hornsey Matthew J. , Gallois Cindy 
Published: March 2009

AbstractIngroup members who criticize their group face much less resistance than outgroup members who say the same thing (the intergroup sensitivity effect). In the context of intergroup conflict, however, it was predicted that treatment of ingroup critics would not be so generous. Muslim Indonesians read an extract from an interview in which the speaker criticized Muslims. The comments were attributed to either another Muslim or to a Christian. Before reading the criticism, half of the participants had read an article describing intense conflict between Muslims and Christians in Indonesia, whereas the other half read a neutral article. As predicted, negativity toward the ingroup critic and the ingroup critic's comments increased in the conflict salience condition, to the point that the intergroup sensitivity effect disappeared. However, conflict salience did not have an effect on attributions of motive or on agreement with the message. Implications for our understanding of “patriotic criticism” are discussed. Copyright © 2009 John Wiley & Sons, Ltd.
Molecular identity of skin and blood T‐cell clones in cutaneous T‐cell lymphoma patients as determined from the migration pattern of the T‐cell receptor‐γ gene by capillary electrophoresis
Authors: Gubler Brigitte , Marty‐Grès Sophie , Guillot Bernard , Eliaou Jean‐François , Dereure Olivier 
Published: March 2009

AbstractThe presence of a dominant clonal T‐cell population in skin lesions is an important clue in the diagnosis of cutaneous T‐cell lymphoma (CTCL). However, it has never been determined whether dominant T‐cell receptor (TCR) rearrangements identified in skin lesions and blood from CTCL patients, displaying strictly identical migration patterns by capillary electrophoresis, actually correspond to identical clones. As this information has potential clinical relevance, TCR‐γ (TCRG) gene‐derived amplified fragments from dominant blood and skin T‐cell clones featuring either identical or slightly different capillary electrophoresis migration patterns were analyzed in eleven CTCL patients. In nine patients with identical electrophoretic migration patterns, sequence analyses revealed the dominant skin and blood T‐cell clones to be identical. In contrast, in two patients displaying slight migration differences between skin and blood samples, the TCRG sequences were distinct. Additionally, capillary electrophoresis appears more sensitive and accurate than heteroduplex analysis and in silico analysis of samples of different origins is possible a posteriori. These results demonstrate the efficacy of capillary electrophoresis in assessing molecular identity and discrepancy of dominant T‐cell populations obtained from different tissues or at different times, facilitating diagnosis and follow‐up.
Monolithic silica xerogel capillary column for separations in capillary LC and pressurized CEC
Authors: Qu Qi‐Shu , Wang Song , Mangelings Debby , Wang Cheng‐Yin , Yang Gong‐Jun , Hu Xiao‐Ya , Yan Chao 
Published: March 2009

AbstractMonolithic capillary columns were prepared by the reaction of a mixture of potassium silicate solution and formamide. The surface of the monolith was coated with a thin film formed by a sol–gel method to increase the surface area of the monolith and simultaneously covered with C8 as stationary phase for reversed‐phase separation. The morphology of the monolithic column was investigated by SEM. Monolithic columns prepared in this manner showed high permeability and can be operated in capillary LC (CLC) mode at a pressure of 20 psi. PAHs were used to evaluate the separation performance of the stationary phase using CLC and pressurized CEC (pCEC). Efficiencies of 20 000 and 28 000 plates per meter for naphthalene were obtained in CLC and pCEC modes, respectively. Improvement in column efficiency and reduction in analysis time over CLC and improvement in operation facility and separation selectivity over CLC were found using pCEC mode.
2‐DE and MS analysis of key proteins in the adhesion of Lactobacillus plantarum, a first step toward early selection of probiotics based on bacterial biomarkers
Authors: Izquierdo Esther , Horvatovich Peter , Marchioni Eric , Aoude‐Werner Dalal , Sanz Yolanda , Ennahar Saïd 
Published: March 2009

AbstractThe identification of cell components involved in probiotic activities is a challenge in current probiotic research. In this work, a new approach based on proteomics as an analytical tool for the identification of characteristic protein profiles related to adhesion to mucin as a model probiotic property was used. Three Lactobacillus plantarum strains with different adhesion rates were used for proteomic analysis: L. plantarum WHE 92 (15.9%), L. plantarum 299 v (9.1%) and L. plantarum CECT 4185 (1.4%). Cell wall extracts were subjected to proteomic analysis of differential protein expression using 2‐DE, tryptic digestion, chip‐LC‐QTOF mass analysis and protein identification using database search. Several proteins, previously reported to be involved in bacterial adhesion: elongation factor EF‐Tu, GroEL chaperonin, molecular chaperone DnaK and glyceraldehyde‐3‐phosphate dehydrogenase were found to be overexpressed in the cell wall proteome of the highly adhesive strain L. plantarum WHE 92. The overexpression of two spots containing GroES co‐chaperonin in the most adhesive strain also suggested the involvement of this protein in the adhesion process. The association of proteomic profiles and proteins with particular probiotic properties opens the way for the use of such profiles and proteins as bacterial biomarkers for the properties of bacteria but probably also for their potential health effects.
2‐D PAGE‐based comparison of proteasome inhibitor bortezomib in sensitive and resistant mantle cell lymphoma
Authors: Weinkauf Marc , Zimmermann Yvonne , Hartmann Elena , Rosenwald Andreas , Rieken Malte , Pastore Alessandro , Hutter Grit , Hiddemann Wolfgang , Dreyling Martin 
Published: March 2009

AbstractAlthough gene expression following bortezomib treatment has been previously explored, direct effects of bortezomib‐induced proteasome inhibition on protein level has not been analyzed so far. Using 2‐D PAGE in five mantle cell lymphoma cell lines, we screened for cellular protein level alterations following treatment with 25 nM bortezomib for up to 4 h. Using MS, we identified 38 of the 41 most prominent reliably detected protein spots. Twenty‐one were affected in all cell lines, whereas the remaining 20 protein spots were exclusively altered in sensitive cell lines. Western blot analysis was performed for 17 of the 38 identified proteins and 70.6% of the observed protein level alterations in 2‐D gels was verified. All cell lines exhibited alterations of the cellular protein levels of heat shock‐induced protein species (HSPA9, HSP7C, HSPA5, HSPD1), whereas sensitive cell lines also displayed altered cellular protein levels of energy metabolism (ATP5B, AK5, TPI1, ENO‐1, ALDOC, GAPDH), RNA and transcriptional regulation (HNRPL, SFRS12) and cell division (NEBL, ACTB, SMC1A, C20orf23) as well as tumor suppressor genes (ENO‐1, FH). These proteins clustered in a tight interaction network centered on the major cellular checkpoints TP53. The results were confirmed in primary mantle cell lymphoma, thus confirming the critical role of these candidate proteins of proteasome inhibition.