bluuebunny/crossref_metadata_2025_split huggingface dataset:
Posterior semicircular canal occlusion for intractable benign positional vertigo: outcome in 55 ears in 53 patients operated upon over 20 years
Authors: Ahmed R M , Pohl D V , MacDougall H G , Makeham T , Halmagyi G M 
Published: May 2012

AbstractObjective:To report the outcome of posterior semicircular canal occlusion surgery for intractable benign positional vertigo, regarding vertigo cure rate and hearing and balance outcomes.Methods:Retrospective review of 53 patients presenting with benign positional vertigo, unresponsive to repositioning manoeuvres, who eventually underwent posterior canal occlusion, over a 20 year period.Results:From 1991 to 2011, 5364 benign positional vertigo patients were treated in our balance disorders clinic; 53 of those who failed to respond to repositioning underwent posterior canal occlusion. All 53 were cured of their benign positional vertigo. Nine suffered some symptomatic permanent hearing loss (>20 dB at low and >25 dB at high frequencies). Ten patients suffered caloric vestibular function deterioration, with mild but permanent subjective imbalance in five; a further 10 patients with no post-operative caloric test changes also had some permanent imbalance. Benign positional vertigo later developed in the operated ear lateral canal in two patients and in the opposite ear posterior canal in eight patients. Two patients needed bilateral sequential posterior canal occlusion.Conclusion:Posterior canal occlusion is a highly effective treatment for intractable benign positional vertigo, with what is probably an acceptable risk to hearing and balance: five of six patients will have no hearing problem and nine of 10 no balance problem after surgery.
Eternity, knowledge, and freedom
Authors: DIEKEMPER JOSEPH 
Published: May 2012

AbstractThis article addresses the problem of divine foreknowledge and human freedom by developing a modified version of Boethius' solution to the problem – one that is meant to cohere with a dynamic theory of time and a conception of God as temporal. I begin the article by discussing the traditional Boethian solution, and a defence of it due to Kretzmann and Stump. After canvassing a few of the objections to this view, I then go on to offer my own modified Boethian solution, according to which temporal reality is fundamentally dynamic, but truth is not. My claim is that there are eternally existing, tenseless propositions, with determinate truth values, but that these are made true by events that come into existence, and are not themselves eternal.
On grounding God's knowledge of the probable
Authors: JENSEN JENNIFER 
Published: May 2012

AbstractA common objection to the Molinist account of divine providence states that counterfactuals of creaturely freedom (CCFs) lack grounds. Some Molinists appeal to brute counterfactual facts about the subject of the CCF in order to ground CCFs. Others argue that CCFs are grounded by the subject's actions in nearby worlds. In this article, I argue that Open Theism's account of divine providence employs would-probably conditionals that are most plausibly grounded by either brute facts about the subject of these conditionals or non-actual entities. As a result, Open Theism's revision of the traditional notion of divine providence is unmotivated. The Molinist can ground CCFs just as easily as the Openist can ground would-probably conditionals but the Molinist has the advantage of maintaining a robust account of divine providence.
Robustness and accuracy of functional modules in integrated network analysis
Authors: Beisser Daniela , Brunkhorst Stefan , Dandekar Thomas , Klau Gunnar W. , Dittrich Marcus T. , Müller Tobias 
Published: May 2012

Abstract
Motivation: High-throughput molecular data provide a wealth of information that can be integrated into network analysis. Several approaches exist that identify functional modules in the context of integrated biological networks. The objective of this study is 2-fold: first, to assess the accuracy and variability of identified modules and second, to develop an algorithm for deriving highly robust and accurate solutions.
Results: In a comparative simulation study accuracy and robustness of the proposed and established methodologies are validated, considering various sources of variation in the data. To assess this variation, we propose a jackknife resampling procedure resulting in an ensemble of optimal modules. A consensus approach summarizes the ensemble into one final module containing maximally robust nodes and edges. The resulting consensus module identifies and visualizes robust and variable regions by assigning support values to nodes and edges. Finally, the proposed approach is exemplified on two large gene expression studies: diffuse large B-cell lymphoma and acute lymphoblastic leukemia.
Contact: marcus.dittrich@biozentrum.uni-wuerzburg.de or tobias.mueller@biozentrum.uni-wuerzburg.de
Supplementary information: Supplementary data are available at Bioinformatics online.
Anonymous nuclear loci in non-model organisms: making the most of high-throughput genome surveys
Authors: Bertozzi Terry , Sanders Kate L. , Sistrom Mark J. , Gardner Michael G. 
Published: May 2012

Abstract
Motivation: When working with non-model organisms, few if any species-specific markers are available for phylogenetic, phylogeographic and population studies. Therefore, researchers often try to adapt markers developed in distantly related taxa, resulting in poor amplification and ascertainment bias in their target taxa. Markers can be developed de novo and anonymous nuclear loci (ANL) are proving to be a boon for researchers seeking large numbers of fast-evolving, independent loci. However, the development of ANL can be laboratory intensive and expensive. A workflow is described to identify suitable low-copy anonymous loci from high-throughput shotgun sequences, dramatically reducing the cost and time required to develop these markers and produce robust multilocus datasets.
Results: By successively removing repetitive and evolutionary conserved sequences from low coverage shotgun libraries, we were able to isolate thousands of potential ANL. Empirical testing of loci developed from two reptile taxa confirmed that our methodology yields markers with comparable amplification rates and nucleotide diversities to ANLs developed using other methodologies. Our approach capitalizes on next-generation sequencing technologies to enable the development of phylogenetic, phylogeographic and population markers for taxa lacking suitable genomic resources.
Contact: terry.bertozzi@samuseum.sa.gov.au
FOXM1 mediates Dox resistance in breast cancer by enhancing DNA repair
Authors: Park Yun-Yong , Jung Sung Yun , Jennings Nicholas B , Rodriguez-Aguayo Cristian , Peng Guang , Lee Se-Ran , Kim Sang Bae , Kim Kyounghyun , Leem Sun-Hee , Lin Shiaw-Yih , Lopez-Berestein Gabriel , Sood Anil K , Lee Ju-Seog 
Published: May 2012

Abstract
Transcription factors are direct effectors of altered signaling pathways in cancer and frequently determine clinical outcomes in cancer patients. To uncover new transcription factors that would determine clinical outcomes in breast cancer, we systematically analyzed gene expression data from breast cancer patients. Our results revealed that Forkhead box protein M1 (FOXM1) is the top-ranked survival-associated transcription factor in patients with triple-negative breast cancer. Surprisingly, silencing FOXM1 expression led breast cancer cells to become more sensitive to doxorubicin (Dox). We found that FOXM1-dependent resistance to Dox is mediated by regulating DNA repair genes. We further demonstrated that NFκB1 interacts with FOXM1 in the presence of Dox to protect breast cancer cells from DNA damage. Finally, silencing FOXM1 expression in breast cancer cells in a mouse xenograft model significantly sensitized the cells to Dox. Our systematic approaches identified an unexpected role of FOXM1 in Dox resistance by regulating DNA repair genes, and our findings provide mechanistic insights into how FOXM1 mediates resistance to Dox and evidence that FOXM1 may be a promising therapeutic target for sensitizing breast cancer cells to Dox.
Effect of pressurized steam on AA1050 aluminium
Authors: Jariyaboon M. , Møller P. , Ambat R. 
Published: May 2012

PurposeThe purpose of this paper is to understand the effect of pressurized steam on surface changes, structures of intermetallic particles and corrosion behavior of AA1050 aluminium.Design/methodology/approachIndustrially pure aluminium (AA1050, 99.5 per cent) surfaces were exposed to pressurized steam produced from a commercial pressure cooker at the maximum temperature of 116oC for 10 min. Surface morphology was observed using SEM‐EDX and FIB‐SEM. Phase identification and compositional depth profiling were investigated using XRD and GDOES, respectively. Potentiodynamic polarization measurements were used to study corrosion behavior.FindingsA 590 nm boehmite oxide layer was generated on AA1050 associated with partially dissolved and/or fallen off Fe‐containing intermetallic particles after exposure to pressurized steam. A significant reduction (25 times) in anodic and cathodic reactivities was observed due to the formation of the compact oxide layer.Originality/valueThis paper reveals a detailed investigation of how pressurized steam can affect the corrosion behaviour of AA1050 aluminium and the structure of Fe‐containing intermetallic particles.
Reference Services Review: content analysis, 2006‐2011
Authors: Mahraj Katy 
Published: May 2012

PurposeThe purpose of this paper is to present a retrospective analysis of the content published in Reference Services Review from 2006 through 2011.Design/methodology/approachThe author manually reviewed the content of all journal issues from 2006 through 2011 using the Emerald web site. The information reviewed was number of articles per issue; author affiliations; article format; and article titles, abstracts, and keywords. The type, size, and location of author institutions were confirmed using institutions' official web sites as necessary.FindingsThe paper finds that Reference Services Review has published an average of 40 articles per year. The majority of articles focus on topics in information literacy and reference services, with consistent coverage of emerging technologies, working with diverse populations, library space, and management. The majority of contributors are affiliated with large academic institutions in the USA, with some representation from liberal arts colleges, public libraries, community colleges, and international authors.Originality/valueThis analysis consolidates data on the volume, focus, and authorship of Reference Services Review as the journal reaches its 41st year of publication. The data provide a snapshot of trends in the field's professional and scholarly literature with implications for trends in academic librarianship.
Students tweet the darndest things about your library – and why you need to listen
Authors: Bell Steven 
Published: May 2012

PurposeTwitter is an important communication tool with college students. This article aims to emphasize that, while Twitter is useful for sharing information about the library, more can be learned from using it as a digital listening post.Design/methodology/approachThis is an essay style viewpoint.FindingsThe paper reveals that Twitter is an important vehicle for disseminating information about a library to its community and as a means for maintaining good customer service.Originality/valueThe paper provides useful information on an important communication tool for libraries.
Student preference for tutorial design: a usability study
Authors: Mestre Lori S. 
Published: May 2012

PurposeThis article aims to report on a usability study to assess whether students performed better after working through a screencast library tutorial or a web‐based tutorial with screenshots.Design/methodology/approachThis qualitative study asked 21 students from diverse backgrounds and learning styles to take two learning style inventories prior to a usability study. The students then went through two short tutorials (a static web page tutorial with screenshots and a Camtasia screencast (video) tutorial, as well as a pre‐ and post‐test and debriefing for each. The “think aloud” protocol was used as their movements and voices were recorded using the Camtasia software.FindingsThe results of this study indicate that across all learning preferences students performed much better in recreating tasks when they used a static web page with screen shots than they did after viewing a screencasting tutorial.Practical implicationsSuggestions are offered for ways to create tutorials that are effective for multiple learning styles that will fit into a student's workflow.Originality/valueResults of this study may help inform other librarians in ways to effectively design tutorials and learning objects to meet student needs.
Managing a text reference consortium: the My Info Quest experience
Authors: Luo Lili , Weak Emily 
Published: May 2012

PurposeThis paper aims to describe management and operational considerations for collaborative text reference services.Design/methodology/approachThe authors conducted in‐depth interviews with members of the My Info Quest (MIQ) management team. The paper reports on the interviews in the context of MIQ's operations as the first US nationwide, collaborative text reference service.FindingsMIQ is a non‐hierarchal organization that relies on frequent communication, enthusiastic and dedicated member librarians, and a collective sense of commitment. Challenges and lessons from MIQ's operations are discussed in the following areas: policies and procedures, staffing, service software, training, marketing, communicating and problem solving, and overall project operation.Research limitations/implicationsThis paper examines collaborative text reference service only from the management perspective. Future research should investigate other aspects of collaboratively providing text reference service.Practical implicationsThis paper will help libraries implement and manage collaborative text reference services. Ultimately it will contribute to the development of best practices for text reference service.Originality/valueText reference is the most recent reference development and it does not have a large body of literature. Current reports are primarily of a single library's experience. This paper reports on collaborative service provision. It is the only article to date that examines collaborative text reference service from the management perspective.
A bootstrap test for causality with endogenous lag length choice: theory and application in finance
Authors: Hacker Scott , Hatemi‐J Abdulnasser 
Published: May 2012

PurposeIn all existing theoretical papers on causality it is assumed that the lag length is known a priori. However, in applied research the lag length has to be selected before testing for causality. The purpose of this paper is to suggest that in investigating the effectiveness of various Granger causality testing methodologies, including those using bootstrapping, the lag length choice should be endogenized, by which we mean the data‐driven preselection of lag length should be taken into account.Design/methodology/approachThe size and power of a bootstrap test with endogenized lag‐length choice are investigated by simulation methods. A statistical software component is produced to implement the test, which is available online.FindingsThe simulation results show that this test performs well. An application of the test provides empirical support for the hypothesis that the UAE financial market is integrated with the US market.Social implicationsThe empirical results based on this test are expected to be more precise.Originality/valueThis paper considers a bootstrap test for causality with endogenous lag order. This test has superior properties compared to existing causality tests in terms of size, with similar if not better power and it is robust to ARCH effects that usually characterize financial data. Practitioners interested in causal inference based on time series data might find the test valuable.
Journal based current awareness services for systems librarianship
Authors: Xu Fei 
Published: May 2012

PurposeThis paper aims to explore the effective ways to utilize current awareness services (CAS) for library and information science (LIS) professionals. It seeks to identify core journals for systems librarianship based on Bradford analysis.Design/methodology/approachThe study explored the methods for CAS based on literature review, followed by Bradford analysis of systems librarianship literature, which was conducted by the quantitative analysis approach.FindingsA core journal list for systems librarianship was built based on Bradford analysis. Three effective ways to utilize CAS by table of contents (TOCs) alerts were identified.Originality/valueTo keep up to date with the latest literature in the field of interest, LIS professionals should take advantage of CAS. The study found three effective ways to utilize CAS by TOCs alerts and identified core journals for systems librarianship. The research can help LIS professionals efficiently navigate the information tsunami to obtain the reliable and relevant information that deserves their time and attention, and stay aware of new developments in their area of interest.
Development of modular product architecture through information management
Authors: Shamsuzzoha A.H.M. , Helo Petri T. 
Published: May 2012

PurposeThe aim of this paper is to investigate the importance of information management in modular product architecture for customized product development.Design/methodology/approachThe objective of this research is to analyze product architecture in terms of information exchange and show its influence in product customization. A case study is presented with a view to modelling the information tracking necessary for product architecture and customization.FindingsIn today's volatile business environment, appropriate ways of information management could be an added value for manufacturing firms. This paper deals with the importance of information flow in product architecture. The role of information exchange influences the basic architecture of the product development process, which also affects the general theme of product customization.Research limitations/implicationsThe importance of information flow highlights the design architecture and brings flexibilities to the product development process. This concept is illustrated through a single case example, which may not be translated as a generic output. Multiple case study approaches could be undertaken in future research to rigorously analyze the influence of information exchange on product architecture.Practical implicationsIn order to comply with growing customization, firms are looking for flexible design architecture in their product development process. The presented approach will be beneficial for designers and organizational managers in developing flexible customized product or services.Originality/valueThis paper implements a unique approach to modular product architecture through information dependencies among components and sub‐assemblies. The basic principle of modular product architecture and how it affects product customization are also reported.
Introducing podcast in library service: an analytical study
Authors: De Sarkar Tanmay 
Published: May 2012

PurposeThe purpose of this paper is to provide an overview of the application of podcast in academic and public libraries, focusing on its purposes and characteristic features. It seeks to measure the degree of adoption of podcast in different types of libraries across the continents.Design/methodology/approachA content analysis method was used for data collection. Convenience sampling method was followed to select four samples of population, one from each of the four continents. Data were collected along the checkpoints developed by Nguyen and Tripathi and Kumar, and subsequently modified by the researcher. Microsoft Excel was used to analyze data.FindingsThe analysis revealed that library podcasts have some basic features and are implemented for specific purposes. It also revealed that adoption of podcast varies along the geographical regions. The study found that extension of implementation of podcast is high in North American libraries whereas intension of adoption of podcast is high in Australian libraries. However, the reason of disproportionate use of library podcast may be attributed to the differential internet penetration rate along the regions. The paper also identifies areas where podcast is being effectively used by libraries across the world.Research limitations/implicationsThe present study was limited to North America, Europe, Asia and Australia, and the survey was completely internet‐based, conducted on web sites available in English only. A combination of questionnaire and interview method may enable future researchers to measure the impact of podcast on users' and librarians' attitude and perception, which in turn, will determine the extent to which podcast is capable of motivating and engaging users to harness library facilities.Originality/valueBased on the research findings, the scope of the present study may potentially be expanded with the inclusion of different dimensions to gain a comprehensive understanding on the practicability and usefulness of podcast in different libraries belonging to diverse socio economical levels. The findings will also guide future librarians and web developers alike in designing library web pages so that traditional library services could be provided in an innovative way to meet the expectations and information needs of the users.
Effects of interpersonal trust, team leader support, rewards, and knowledge sharing mechanisms on knowledge sharing in project teams
Authors: Wickramasinghe Vathsala , Widyaratne Ruvini 
Published: May 2012

PurposeThe purpose of this paper is to investigate the effect of interpersonal trust, team leader support, rewards, and knowledge sharing mechanisms on voluntary knowledge sharing in software development project teams in Sri Lanka.Design/methodology/approachSurvey methodology was used and 150 software developers who were directly involved in developing and maintaining a software product from project teams responded. Regression analysis was used for data analysis.FindingsInterpersonal trust and rewards have significant positive effects on knowledge sharing. Although it was anticipated that the team leader support would be a significant predictor of knowledge sharing, the results did not provide evidence for a positive and significant relationship. “Work‐group communications” and “Personal interactions” had significant positive effects on knowledge sharing.Originality/valueIt is expected that the findings of this study will provide useful information to better understand the predictors of the extent of knowledge sharing at the individual level in the context of project teams. By doing so, this exploratory study will be able to establish baseline data and would be a source of general guidance in stimulating future research in this area.