bluuebunny/crossref_metadata_2025_split huggingface dataset:
Conducting rehabilitation groups for people suffering from chronic pain
Authors: Dysvik Elin , Stephens Paul 
Published: May 2010

Dysvik E, Stephens P.International Journal of Nursing Practice2010;16: 233–240 Conducting rehabilitation groups for people suffering from chronic painThe aim of this study was to offer guidelines for counsellors who work with rehabilitation groups of patients with chronic pain. The sample involved nine counsellors engaged in a multidisciplinary pain management programme. Two focus group interviews were conducted. Data were analysed using qualitative content analysis. These indicate that main challenges facing counsellors were related to maintaining constructive group processes and being mentally prepared. The counsellors reported that knowledge concerning self‐awareness, theoretical frameworks and counselling techniques was important. Personal learning included: group leadership, teamwork, grasping the inside story and obtaining supervision. The results show how important it is to have trained counsellors that are well prepared to prevent and deal with challenging group processes. Counsellors need to understand the concept of pain and be acquainted with cognitive behavioural framework and group processes. The results indicate that counsellors perceive regular supervision as supportive and is likely to promote good team functioning.
Depression among mothers of children and adults with an intellectual disability in Turkey
Authors: Yildirim Sari Hatice , Başbakkal Zümrüt 
Published: May 2010

Yildirim Sari H, Başbakkal Z. International Journal of Nursing Practice 2010; 16: 248–253 Depression among mothers of children and adults with an intellectual disability in TurkeyThe aim of this study was to determine sociodemographic factors that play a role in depression among mothers of children and adult with an intellectual disability. The research was conducted in 24 special education and rehabilitation centres in Izmir (in Turkey) provincial centre in which intellectually disabled individuals are taught. A total of 355 mothers were reached in the research. Data were collected using face‐to‐face interviews. Two forms were used for data collection in the research: Family Description Questionnaire Form and Beck Depression Inventory. The mothers included in the study had mean depression scores of 16.7 ± 10.06 (minimum: 0, maximum: 49). There was a significant relation between depression scores of the mothers and education level of the mothers and their spouses and financial status of the families. Mothers with insufficient income and lower education levels were found to be at risk of depression.
Chinese parents' perception of support received and recommendations regarding children's postoperative pain management
Authors: He Hong‐Gu , Vehviläinen‐Julkunen Katri , Pölkki Tarja , Pietilä Anna‐Maija 
Published: May 2010

He H‐G, Vehviläinen‐Julkunen K, Pölkki T, Pietilä A‐M. International Journal of Nursing Practice 2010; 16: 254–261 Chinese parents' perception of support received and recommendations regarding children's postoperative pain managementThe aims of this study are to describe Chinese parents' perceptions of informational and emotional support received from nurses and their recommendations for improvement in the management of their child's postoperative pain. Data were collected using a questionnaire survey completed by 206 parents of 6‐ to 12‐year‐old child hospitalized in 12 wards in five provincial hospitals in Fujian Province, China, in 2004. Findings indicated that parents experienced negative feelings such as worry (91%) and anxiety (59%). Most of them reported they had received sufficient information on outcomes of surgical procedure (85%) and postoperative recovery process (84%), but fewer reported they had received sufficient information on pain medication (51%) and non‐pharmacological pain‐relieving methods (59%). Parents made some recommendations, which centred mainly on nurses' use of non‐pharmacological methods. Findings suggest that parents need more information related to pain management and their understanding of the information should be ensured.
Integrating clicker technology at nursing conferences: An innovative approach to research data collection
Authors: Solecki Susan , Cornelius Frances , Draper Judy , Fisher Kathleen 
Published: May 2010

Solecki S, Cornelius F, Draper J, Fisher K. International Journal of Nursing Practice 2010; 16: 268–273 Integrating clicker technology at nursing conferences: An innovative approach to research data collectionA pilot demonstration of integrating an audience response system, that is, ‘clickers’ at a nursing education conference as an engaging tool for using the research process for learning through immediate research results is presented. A convenience sample of nursing conference attendees were surveyed using clicker technology before a panel presentation on the ‘Impaired Health Professional'. The 208 subjects who used the clickers were mostly women (93%) and were nurse educators (81%) with at least 20 years of nursing experience (75%). The ease of data collection, real‐time analysis, the active engagement of both participant and presenter were all findings of this study. The utility of this tool as a stimulus for discussion and learning was also reported. Pilot testing the clicker at an education conference for data collection and educational purposes was an important goal and positive outcome of this study. Researchers and educators are advised on the planning steps required to make this a successful experience.
Overcrowding in medium‐volume emergency departments: Effects of aged patients in emergency departments on wait times for non‐emergent triage‐level patients
Authors: Knapman Mary , Bonner Ann 
Published: May 2010

Knapman M, Bonner A. International Journal of Nursing Practice 2010; 16: 310–317 Overcrowding in medium‐volume emergency departments: Effects of aged patients in emergency departments on wait times for non‐emergent triage‐level patientsThis study aims to examine patient wait times from triaging to physician assessment in the emergency department (ED) for non‐emergent patients, and to see whether patient flow and process (triage) are impacted by aged patients. A retrospective study method was used to analyse 185 patients in three age groups. Key data recorded were triage level, wait time to physician assessment and ED census. Multiple linear regression analysis was used to determine the strength of association with increased wait time. A longer average wait time for all patients occurred when there was an increase in the number of patients aged ≥ 65 years in the ED. Further analysis showed 12.1% of the variation extending ED wait time associated with the triage process was explained by the number of patients aged ≥ 65 years. In addition, extended wait time, overcrowding and numbers of those who left without being seen were strongly associated (P < 0.05) with the number of aged patients in the ED. The effects of aged patients on ED structure and process have significant implications for nursing. Nursing process and practice sets clear responsibilities for nursing to ensure patient safety. However, the impact of factors associated with aged patients in ED, nursing's role and ED process can negatively impact performance expectations and requires further investigation.
Association between HCV amino acid substitutions and outcome of peginterferon and ribavirin combination therapy in HCV genotype 1b and high viral load
Authors: Toyoda Hidenori , Kumada Takashi , Tada Toshifumi , Arakawa Takahiro , Hayashi Kazuhiko , Honda Takashi , Katano Yoshiaki , Goto Hidemi 
Published: May 2010

AbstractBackground and Aim:  We prospectively compared the sensitivity to interferon (IFN) and the efficacy of antiviral combination therapy with peginterferon (PEG‐IFN) and ribavirin for chronic hepatitis C virus (HCV) genotype 1b infection according to the amino acid sequences of the HCV core, E1, and NS5A regions reported to be associated with the outcome of antiviral therapy.Methods:  A total of 107 patients with HCV genotype 1b were investigated. All patients received combination therapy with PEG‐IFN alpha‐2b and ribavirin. Amino acids 70 and 91 (core), 139 (E1), and 2209–2248 (NS5A) of HCV were analyzed by direct nucleotide sequencing.Results:  The reduction in HCV RNA concentration at 24 h after a single administration of conventional IFN‐alpha and after the start of combination therapy was significantly less marked, and rates of complete early virologic response, end‐of‐treatment response, and sustained virologic response (SVR) were significantly lower (all P < 0.0001) in patients with glutamine at amino acid 70 (n = 29) than in those with arginine at that position (n = 70). We found no differences associated with the other amino acid positions. Amino acid 70 was an independent factor for the responses to the therapy in multivariate analysis.Conclusion:  The identity of amino acid 70 of the HCV core region affected the sensitivity to IFN; patients with glutamine at amino acid 70 of HCV showed resistance to IFN. Consequently, it strongly affected the outcome of combination therapy with PEG‐IFN and ribavirin in Japanese patients with HCV genotype 1b.
Effects of sphingolipid synthesis inhibition on cholesterol gallstone formation in C57BL/6J mice
Authors: Lee Beom Jae , Kim Jae Seon , Kim Byung Kyu , Jung Sung Joo , Joo Moon Kyung , Hong Seung Goun , Kim Jang Soo , Kim Ji Hoon , Yeon Jong Eun , Park Jong‐Jae , Byun Kwan Soo , Bak Young‐Tae , Yoo Hwan‐Soo , Oh Seikwan 
Published: May 2010

AbstractBackground:  Sphingolipids play a very important role in cell membrane formation, signal transduction and plasma lipoprotein metabolism. The first rate‐limiting step in the sphingolipid biosynthetic pathway is catalyzed by serine palmitoyltransferase (SPT), and myriocin is a potent and specific inhibitor of SPT. We investigated the impact of SPT inhibition on cholesterol gallstone formation in C57BL/6J mice.Methods:  Three groups of eight‐week‐old C57BL/6J mice were utilized. Each group consisted of 20 mice; group A, B, and C were fed normal chow, lithogenic diet with phosphate buffered saline, and lithogenic diet with myriocin (0.3 mg/kg), respectively, for 6 weeks. The ceramide levels in both serum and bile were assessed by high performance liquid chromatography analysis. Protein expression of ERK, JNK and p38 in the extracted gallbladder were determined by Western‐blot analysis.Results:  Myriocin treatment caused a significant decrease in the rate of cholesterol gallstone formation. The lithogenic diet mice (group B) showed the highest ceramide activities in both the serum and bile among all the tested groups and there was significant suppression of the ceramide levels in both the serum and bile of the myriocin‐treated mice (group C, p < 0.05). Phosphorylation of p38 in the gallbladder was increased in the lithogenic‐diet mice and the expression of phosphorylated p38 was significantly suppressed in the myriocin treated mice.Conclusions:  SPT inhibition by myriocin suppressed gallstone formation and the levels of ceramide in both the serum and bile. p38 in the cellular signaling pathways might be associated with cholesterol gallstone formation.
Aminotransferases and muscular diseases: A disregarded lesson. Case reports and review of the literature
Authors: Veropalumbo Claudio , Del Giudice Ennio , Esposito Gabriella , Maddaluno Sergio , Ruggiero Lucia , Vajro Pietro 
Published: May 2010

AbstractThe aim of this study was to call the attention to the often disregarded message that hypertransaminasemia may be a marker of both liver and muscle diseases by presenting personal case reports and a systematic literature review. Three male children (mean age 5.7 years) were inappropriately addressed, during the last 12 months, to our paediatric liver unit for diagnostic work‐up of a chronic hypertransaminasemia of unknown origin. In one of them, a liver biopsy had already been performed. On admission, physical examination, evaluation of serum levels of creatine kinase, and dystrophin genetic testing finally led to a diagnosis of muscular dystrophy. One hundred fourteen similar cases, 21 with unnecessary liver biopsy, were found by Medline search. Expensive and invasive tests planned to investigate liver diseases should be postponed until alternative sources of increased serum aminotransferases, primarily myopathic injury, have been excluded.
What will it take to stop the needless deaths of millions of women and children each year?
Authors: Williams Phoebe 
Published: May 2010

AbstractEach year, almost 10 million children die before their fifth birthday; the majority from easily preventable diseases such as diarrhoea, pneumonia and malaria. Furthermore, 10 million women endure pregnancy‐related morbidities annually while 500,000 die in childbirth. The link between maternal and child health is inextricable and worldwide inequities continue to widen: 99% of all neonatal deaths occur in developing countries, while maternal mortality rates are 1,000 times greater for women in poor countries compared to those living in rich nations. These discrepencies continue to persist despite the presence of a multitude of simple, cost‐effective interventions which could save the lives of millions of women and children worldwide each year for a fraction of the cost associated spent on health care in the developed world.
Sudden unexpected death in epilepsy in children
Authors: Meyer Sascha , Shamdeen Mohammed Ghiath , Gottschling Sven , Strittmatter Matthias , Gortner Ludwig 
Published: May 2010

AbstractSudden unexpected death in epilepsy (SUPEP) is the commonest cause of seizure‐related mortality in people with intractable epilepsy. The incidence of SUDEP varies in different epilepsy populations, with lower rates in population‐based studies, higher in referral populations and clinical trials of adjunct drugs for complex partial epilepsy, and highest rates for surgical series. Certain risk factors for SUDEP have been identified, with seizure activity being one of the strongest risk factor for SUDEP. Suspected underlying mechanisms include cardiac dysrhythmias, seizure‐related apnoea and postictal respiratory arrest. Prevention of SUDEP has centred on seizure control, and SUDEP incidence has been reduced by epilepsy surgery in some studies. In this review, we present epidemiological data, and discuss risk factors and underlying pathophysiological mechanisms that are associated with SUDEP in children.
Physical activity policies and practices of childcare centres in Australia
Authors: Wolfenden Luke , Neve Melinda , Farrell Louise , Lecathelinais Christophe , Bell Colin , Milat Andrew , Wiggers John , Sutherland Rachel 
Published: May 2010

Aim:  The aim of this study was to describe the physical activity‐related policies and practices of childcare services; and to determine if service size, socioeconomic or remoteness characteristics predict such policies and practices.Methods:  Authorized supervisors of 216 licensed pre‐schools and long day care centres participated in a brief telephone survey.Results:  Few services had a written physical activity policy, programmed time each day for fundamental movement skill development, or had staff trained in physical activity. Twenty‐eight percent of pre‐schools and 30% of long day care centres provided daily opportunities for children 3–5 years to participate in sedentary screen activities. Rural pre‐schools and long day care centres were more likely to program time for fundamental movement skills development, as were pre‐schools from higher socioeconomic areas.Conclusions:  There is substantial scope for childcare services to modify their policies and practices to be more supportive of child physical activity.
Estimating the hydration status in nephrotic patients by leg electrical resistivity measuring method
Authors: JIANG FENG , BO YUHONG , CUI TAIGEN , ZHOU YILUN , LI ZHONGXIN , MA LIJIE , BI ZENGQI 
Published: May 2010

ABSTRACT:Aim:  For years, bioelectrical impedance analysis has been widely used to evaluate the hydration status in dialysis patients. However, its value in assessment and controlling the hydration status in non‐dialysis patients with kidney disease, such as nephrotic syndrome, is little mentioned. Because a simple and accurate method to evaluate the hydration status of nephrotic patients is not available, the aim of the present study was to assess the value of leg electrical resistivity measurement in controlling the hydration status of nephrotic patients.Methods:  The study investigated 46 nephrotic patients with a mean age of 41.65 ± 17.15 years, 47.8% of whom were female. The patients were divided into remission and relapse groups according to their serum albumin concentration and oedema. Four hundred and twenty‐seven healthy persons were studied as normal control. Their hydration status estimated by leg electrical resistivity was studied.Results:  There was significant negative correlation between leg electrical resistivity and percentage of extracellular fluid (ECF) measured by the bromide dilution method. The percentage of ECF estimated by the leg electrical resistivity in the relapse group was significantly larger than that of the remission group, but it was approximately the same in the remission group as in the normal control. For nephrotic patients in the relapse group, after they ahcieved remission, their percentage of ECF estimated by the leg electrical resistivity was significantly less than that before treatment, and was close to that of the normal control.Conclusion:  Leg electrical resistivity measurement is a simple, non‐invasive and valuable method for controlling the hydration status in patients with nephrotic syndrome.
Changes in Purine Metabolism and Production of Oxygen Free Radicals by Intermittent Partial Umbilical Cord Occlusion in Chronically Instrumented Fetal Lambs
Authors: Masaoka Naoki , Hayakawa Yasuhito , Ohgame Sachiko , Sakata Hisaei , Satoh Kazuo , Takahashi Hideo 
Published: May 2010

AbstractObjective: Undetected umbilical‐cord compression has been suggested to be implicated in unexplained fetal brain damage. We tested the hypothesis that the generation of oxygen‐free radicals (OFRs) during intermittent partial umbilical cord occlusion might play a causal role in antenatal CNS injury.Methods: Using 7 established chronically instrumented fetal lambs, intermittent partial occlusion of the umbilical circulation was produced according to the method of Clapp et al. for 1 of every 3 minutes for 2 hours. A microdialysis probe was implanted in the fetal brain white matter. Normal saline was infused, and the perfusate obtained at 2 μl/min. Hypoxanthine (HX), xanthine (XA), and inosine‐5‐monophosphate (IMP) concentrations in the perfusate and blood samples obtained from fetal jugular veins were assayed by HPLC. Concurrently, the perfusate, which contained superoxide produced in the brain, when mixed with cypridina luciferin analogue extracorporally, caused chemiluminescence that in 4 cases was measured by a highly sensitive electronic fluorescence detector.Results:

HX, XA, and IMP concentrations in the blood and perfusate were higher than in the control during the intermittent partial occlusion of the umbilical circulation period and returned to control levels during the recovery period.
The residual chemiluminescence of perfusate revealed that the intermittent partial occlusion of the umbilical circulation level was about 100% higher than the control level, and during the recovery period the level returned to the control level.
The chemiluminescence during the intermittent partial occlusion of the umbilical circulation period was inhibited by infusion through the fetal jugular vein of 1 μM polyethylene glycol conjugated superoxide dismutase.

Conclusions: During the intermittent partial occlusion of the umbilical circulation period the fetal brain tissue releases a large amount of OFRs, and a portion of these might be synthesized by the increased conversion of HX to XA. This phenomenon might play an important role in the etiology of fetal brain injury.
Immunohistochemical Evidence of the Mesothelial Histogenesis of a Uterine Adenomatoid Tumor
Authors: Satoh Yuzuru , Hiraguchi Masaki , Matuura Tadao , Takasu Koushou 
Published: May 2010

AbstractWe present rare case of a uterine adenomatoid tumor. In order to characterize the diversity of immunoreactive antigens associated with mesothelial differentiation, we immunohistochemically examined the tumor's epithelioid and myofibromatoid components, as well as the biphasic pattern of its adenomatoid changes. Immunostaining of tumor cells was positive for high‐and low‐molecular‐weight cytokeratins and vimentin. Specific immunoreactions with antibodies against desmin, α‐actin, and the S‐100 protein also were observed. The present adenomatoid tumor can be explained in terms of various transformations and typical alterations in mesothelioma cells: (1) the mesothelial cells had differentiated to epithelial and stromal components, concomitant with the presence of predominant reactive foci; (2) intermediate cells expressed different types of cytoskeletal intermediate filament proteins (IMPs); and (3) the patterns of fibromatoid and leiomyoid differentiation resembled those of a benign mesothelioma of the ovarian or oviductal peritoneum. Our immunohistochemical investigations indicated that the present tumor exhibited the histogenesis of a true mesothelioma, an adenomatoid mesotheliorna.
Intrahepatic Vein Fetal Blood Sampling: Current Role in Prenatal Diagnosis
Authors: Chinnaiya Anandakumar , Venkat Annapoorna , Dawn Chia , Chee Wong Yee , Choo Koh Bee , Gole Leena Abhijit , Meng Chua Tsei 
Published: May 2010

AbstractObjective: To identify the site of fetal blood sampling (FBS) with lesser complications; and also analyses the reasons for targetting the intrahepatic vein (IHV) for FBS.Methods: Fetal blood sampling (FBS) performed on 382 women over a period of 7 years at the National University Hospital, Singapore was analysed. FBS was performed from 13 weeks of gestational age onwards. In 76.4% (292 of 382) the intrahepatic part of the umbilical vein (IHV) was targetted; in 18.3% (70 of 382) percutaneous umbilical cord sampling (PUBS) was performed; in 5.2% (20 of 382) cardiocentesis was performed to obtain fetal blood.Results: Multivariate analysis showed an increase in odds of fetal loss for umbilical cord and cardiocentesis groups compared with the IHV FBS group. It was statistically significant (p < 0.01) only in the cardiocentesis group for fetal loss at < 2 weeks of performing the procedure.
Ligation of Internal Iliac Arteries in Pelvic Haemorrhage
Authors: Das Birendra N. , Biswas Asok K. 
Published: May 2010

AbstractObjective: To study the value of bilateral ligation of internal iliac arteries in the management of intractable postpartum haemorrhage and to curtail blood transfusion during operations for gynaecological cancers.Methods: Internal iliac arteries were ligated in 15 cases of PPH, 4 cases of secondary haemorrhage after hysterectomy and in 27 cases of gynaecological cancers during surgery, over a period of 5 years in a general hospital at Calcutta.Results: The method controlled PPH in all cases except one who required hysterectomy. Secondary haemorrhage was arrested in all. No blood transfusion was necessary during operations for gynaecological cancers except one.Conclusion: The method was effective in 75% of atonic PPH and in majority of PPH due to other causes including caesarean section. It almost entirely avoid blood transfusion during operation for gynaecological cancers. The procedure was simple and did not involve any hazard.