bluuebunny/crossref_metadata_2025_split huggingface dataset:
Withdrawn: ABCA4 is ubiquitously expressed in mouse tissues and forms high molecular weight complexes
Authors: Lechward Katarzyna A. , Glaser Walter , Falkner Susanne 
Published: January 2010

AbstractNotice of withdrawal: The following article from Journal of Cellular Biochemistry, “ABCA4 is ubiquitously expressed in mouse tissues and forms high molecular weight complexes” by Lechward K et al., published online on 20 Jan 2010 in Wiley InterScience (www.interscience.wiley.com), has been withdrawn by agreement between the journal Editor‐in‐Chief, Dr. Gary S Stein and Wiley Liss, Inc.
Dr. Gary S Stein,
Editor‐in‐Chief,
Journal of Cellular Biochemistry
SnCl2 · 2H2O‐catalyzed one‐pot synthesis of 4(3H)‐quinazolinones from anthranilic acid, ortho esters, and amines under solvent free conditions
Authors: Wang Min , Song Zhiguo , Zhang Tingting 
Published: January 2010

Abstract
magnified image A simple, efficient, and green procedure for the one‐pot synthesis of 4(3H)‐quinazolinones by three components condensation of anthranilic acid, ortho esters, and amines in the presence of SnCl2 · 2H2O has been developed. The reaction occurred within short reaction time at room temperature under solvent‐free conditions to afford the title products in excellent yields. J. Heterocyclic Chem., (2010).
Role of MEK‐ERK pathway in morphine‐induced conditioned place preference in ventral tegmental area of rats
Authors: Lin XiaoJing , Wang QingSong , Ji Jianguo , Yu Long‐Chuan 
Published: January 2010

AbstractA major goal of research on drug addiction is to develop the effective treatments to deal with the long‐term behavioral disorders especially reinstatement induced by the addictive drugs such as opiates, cocaine, and cannabinoid. The molecular mechanisms underlying these substance‐related disorders remain unclear so far. Here we used the model of morphine‐induced conditioned place preference (CPP) in rats to mimic the progress of drug‐taking, withdrawal and relapse in human. The tissue of ventral tegmental area (VTA), one of the most important brain structures associated with abused drug‐related disorders, was taken and two‐dimensional electrophoresis (2‐DE) was performed to analyze and compare the changes of protein expression patterns during the different stages of morphine‐induced CPP. First, we found that there were 80 proteins identified to be changed in the process of morphine‐induced CPP. Furthermore, as the mitogen‐activated protein kinase kinase 1 (MAPKK1) was increased significantly in the stages of establishment and reinstatement, we confirmed the change of activated extracellular signal‐regulated kinase (ERK) by Western blotting in VTA tissue and cultured cell. The results demonstrated that the activated MEK‐ERK pathway by chronic morphine treatment in VTA was involved in morphine‐induced reinstatement. Moreover, inhibition of MEK‐ERK pathway by infusion the MEK inhibitor U0126 in VTA blocked the establishment of morphine‐induced CPP. The present study found significant changes in a group of protein expressions in VTA during morphine‐induced CPP and further confirmed the role of MEK‐ERK cell signaling pathway of VTA in morphine addiction. © 2010 Wiley‐Liss, Inc.
Acoustic overstimulation modifies Mcl‐1 expression in cochlear sensory epithelial cells
Authors: Hu Bo Hua , Cai Qunfeng 
Published: January 2010

AbstractAcoustic overstimulation causes apoptotic cell death in the cochlea. This death process is mediated, in part, by the mitochondrial signaling pathway involving Bcl‐2 family proteins. Myeloid cell leukemia sequence 1 (Mcl‐l) is an antiapoptotic member of the Bcl‐2 family. Its involvement in noise‐induced hair cell death has not been characterized. Here we report the endogenous expression and the noise‐induced expression of Mcl‐1 in Sprague Dawley rat cochleae. In the sensory epithelia of normal cochleae, there is strong constitutive expression of Mcl‐1 mRNA, with an expression level higher than that of many other Bcl‐2 family genes. The Mcl‐1 protein is preferentially expressed in outer hair cells. After exposure to a high level of continuous noise at 115‐dB sound pressure level for 1 hr, Mcl‐1 expression displays a time‐dependent alteration, with up‐regulation of Mcl‐1 mRNA at 4 hr postexposure and protein up‐regulation at 1 day postexposure. Western blot analysis reveals the up‐regulated Mcl‐1 as the full‐length form of Mcl‐1. Immunolabeling of the Mcl‐1 protein reveals the early increase in Mcl‐1 immunoreactivity in the nuclear region of the hair cells displaying apoptotic phenotypes and a subsequent increase in survival hair cells. These results suggest that Mcl‐1 is involved in the regulation of hair cell pathogenesis resulting from acoustic stress, possibly by influencing the nuclear events of apoptosis. © 2010 Wiley‐Liss, Inc.
Formal ratification of the Quaternary System/Period and the Pleistocene Series/Epoch with a base at 2.58 Ma
Authors: Gibbard Philip L. , Head Martin J. , Walker Michael J. C. ,   the Subcommission on Quaternary Stratigraphy
Published: January 2010

AbstractIn June 2009, the Executive Committee of the International Union of Geological Sciences (IUGS) formally ratified a proposal by the International Commission on Stratigraphy to lower the base of the Quaternary System/Period to the Global Stratotype Section and Point (GSSP) of the Gelasian Stage/Age at Monte San Nicola, Sicily, Italy. The Gelasian until then had been the uppermost stage of the Pliocene Series/Epoch. The base of the Gelasian corresponds to Marine Isotope Stage 103, and has an astronomically tuned age of 2.58 Ma. A proposal that the base of the Pleistocene Series/Epoch be lowered to coincide with that of the Quaternary (the Gelasian GSSP) was also accepted by the IUGS Executive Committee. The GSSP at Vrica, Calabria, Italy, which had hitherto defined the basal boundary of both the Quaternary and the Pleistocene, remains available as the base of the Calabrian Stage/Age (now the second stage of the revised Pleistocene). In ratifying these proposals, the IUGS has acknowledged the distinctive qualities of the Quaternary by reaffirming it as a full system/period, correctly complied with the hierarchical requirements of the geological timescale by lowering the base of the Pleistocene to that of the Quaternary, and fully respected the historical and widespread current usage of both the terms ‘Quaternary’ and ‘Pleistocene’. Copyright © 2009 John Wiley & Sons, Ltd.
Isolation of inulin‐type oligosaccharides from Chinese traditional medicine: Morinda officinalis How and their characterization using ESI‐MS/MS
Authors: Yang Zhenmin , Yi Yongtao , Gao Chuanchuan , Hou Dengke , Hu Jun , Zhao Mingyue 
Published: January 2010

AbstractInulin‐type oligosaccharides with different DP were prepared by size‐exclusion chromatography and purity of each oligosaccharide was determined by HPLC equipped with cyclodextrin‐bond column. The purities of obtained inulin‐type oligosaccharides with different DP were more than 98% by one‐step process. The DP and molecular weight were obtained through ESI‐MS in negative mode. The characterization of the inulin‐type oligosaccharides with different DP was studied by MS/MS spectra obtained by collision‐induced dissociation of molecular ions ([M−H]−). When the DP was lower, the fragment ions were formed through cross‐ring cleavages of two bonds within the sugar ring and glycosidic cleavages. However, with the increase of DP, the ions resulting from glycosidic cleavages between two sugar residues were predominant.
Investigation on nanocrystalline iron‐cobalt‐vanadium alloy processed by equal channel angular pressing (ECAP)
Authors: Jiacai K. , Zhongze D. 
Published: January 2010

AbstractNanocrystalline iron‐cobalt‐vanadium alloy was fabricated by Equal‐Channel Angular Pressing (ECAP). Microstructural evolution at different passes of ECAP and the effect of φ in the ECAP were researched. The results revealed that a phase slowly turned to γ phase and followed the form of dislocation cells in the iron‐cobalt‐vanadium alloy with the increase of severe plastic deformation. At last, it became reasonably finer bands of subgrains. The results with intersect at an angle φ of 90° was better than with at an angle φ of 120°. After three passes of ECAP, at an angle φ of 90°, the nanocrystalline microstructure could be obtained. The grain size was reduced from 30 μm in the initial state to 400nm.
Short‐term creep behavior of chromium rich hot‐work tool steels
Authors: Wurmbauer H. , Panzenböck M. , Leitner H. , Scheu C. , Clemens H. 
Published: January 2010

AbstractHot‐work tool steels represent a group of steels which are used for metal forming operations at elevated temperatures, e. g. die casting, extrusion molding and drop forging. During application such working tools are exposed for a short time to both high temperatures and mechanical stresses. Short‐term creep tests of two chromium rich martensitic hot‐work tool steels which basically differ in their molybdenum, carbon and silicon content were conducted at temperatures in the range of 540°C to 600°C and at stress levels ranging from 280 MPa to 600 MPa. Both steels showed a minimum strain rate, at approximately 1/6 time to rupture, instead of a steady‐state creep range. The stress exponents of both steels indicate dislocation creep as the dominant creep mechanism. Microstructural investigations showed that in both steels the secondary hardening carbides are type of MC and M2C. A higher content of molybdenum and carbon causes a higher volume fraction of these carbides and results in a better short‐term creep behavior.Warmarbeitsstähle werden häufig als Werkzeuge beim Druckgießen, Strangpressen oder Gesenkschmieden eingesetzt. Während des Einsatzes sind diese Stähle immer wieder hohen Temperaturen und Spannungen ausgesetzt. In dieser Arbeit wurden an zwei chromreichen Warmarbeitsstählen, welche sich hauptsächlich in ihrem Molybdän‐, Kohlenstoff‐ und Siliziumgehalt voneinander unterscheiden, Kurzeitkriechversuche durchgeführt. Die Versuchstemperaturen lagen dabei zwischen 540°C und 600°C, währenddessen die Spannungen von 280 MPa bis 600 MPa reichten. Bei beiden Stählen trat eine minimale Kriechrate bei ungefähr einem Sechstel der Bruchzeit auf. Ein konstanter sekundärer, so genannter „Steady‐State”︁, Kriechbereich wurde bei keinem der durchgeführten Kriechversuche festgestellt. Der Spannungsexponent von beiden Stählen weist auf Versetzungskriechen als den dominierenden Kriechprozess hin. Untersuchungen der Mikrostruktur an beiden Stählen ergaben Sekundärhärtekarbide vom Typ MC und M2C. Ein erhöhter Molybdän und Kohlenstoffgehalt führt zu einem höheren Volumenanteil an diesen Karbiden, verbunden mit einem besseren Kurzzeitkriechverhalten.
Mathematical model for calculating the strength of a single lap adhesive joint intended for the service in sea water
Authors: Kožuh Z. , Kralj S. , Garašic I. , Dorn L. 
Published: January 2010

AbstractThe application of adhesives in the joining of materials is limited not only by the impossibility of accurately calculating the strength of an adhesive bonded joint, but also by incomplete knowledge of effect of service conditions upon degradation of adhesive forces. This is particularly true for adhesive bonded joints intended for service in sea water. In the introductory part of the paper, the effects of liquids upon the strength of adhesive bonded joints are described as reported in the reference publications. Difficulties encountered in using adhesive bonded joints in liquids and other media with high humidity are considered. In the experimental part of the paper, the authors endeavour to explain the effects of sea water upon the strength of single lap adhesive bonded joints of high alloyed steel.Neben der Unmöglichkeit der exakten Klebungsfestigkeitsberechnung, ist die Unkenntnis der Adhäsionsschwächung mit der Zeit eine Einschränkung für die Klebtechnikanwendung insbesondere bei der Anwendung unter Meerwasser. In der Einführung dieser Arbeit wird die Auswirkung von Flüssigkeiten auf die Klebfestigkeit nach Literaturangaben beschrieben und es werden die Schwierigkeiten bei der Klebanwendung in Flüssigkeiten und Medien mit großer Feuchtigkeit angezeigt. Im experimentellen Teil der Arbeit wird untersucht wie sich die Meereswassereinwirkung auf die Festigkeit von einschnittig überlappten Klebverbindungen an hochlegierten Stählen auswirkt.
Mathematical‐physical model of resistance sintering with current conducting electrode punches of steel ceramic composites
Authors: Guk S. , Yanina A. , Müller W. , Kawalla R. 
Published: January 2010

AbstractIm Rahmen der dargestellten Untersuchungen wurde das konduktive Sintern eines TRIP‐Matrix‐Composites auf der Basis eines austenitischen nichtrostenden Stahls mit TRIP‐Effekt und einer MgO‐teilstabilisierten ZrO2‐Keramik durchgeführt. Der Einfluss des Keramik‐Anteiles auf die Temperaturentwicklung, der im Bereich zwischen 5 und 20%‐Vol. variiert worden ist, wurde anhand von Experimenten ermittelt und durch Aufstellen eines mathematisch‐physikalischen Modells verallgemeinert. Die Ergebnisse zeigten eine sehr gute Übereinstimmung mit dem Experiment. Damit lässt sich eine vollständige Beschreibung der Temperaturverteilung und ‐entwicklung während des konduktiven Sinterns eines Stahl‐Keramik‐Composites näherungsweise durchführen, um letztlich zur Auswahl optimaler Aufheizprozesse, die sich durch einen geringen Temperaturgradienten über den Probenquerschnitt kennzeichnen, beizutragen. Diese Methodik kann einen nützlichen Beitrag zur Beherrschung einer optimalen Sintertechnologie leisten.In the present study the resistance sintering of TRIP‐Matrix‐composites on the base of non‐rusting austenitic steel with TRIP‐effect and MgO‐partial‐stabilized ZrO2 ceramic was carried out. The influence of the ceramics containing, which has been varied in the area between 5 and 20%‐Vol., on the temperature development, was determined on the basis of experiments and was generalised by putting up a mathematical‐physical model. The results showed a very good correspondence with the experiment. With it lets made an entire approximately description of the temperature distribution and temperature development itself during the resistance sintering of a steel‐ceramic‐composites to contribute optimum of heating rate which marks itself by a low temperature gradient about the test cross section. This methodology is able to do a useful contribution to the control of optimum sinter technology.
Vascular pedicle avulsion in free flap breast reconstruction: A case of diep flap salvage following early avulsion of venous anastomosis and literature review
Authors: Lykoudis Efstathios G. , Ziogas Dimosthenis E. , Papanikolaou George E. 
Published: January 2010

AbstractFree flap vascular pedicle avulsion represents an extremely rare complication in reconstructive microsurgery. Very few cases have been reported in the literature, most of them identified in free flap breast reconstruction. As a result, little data is currently available on the etiology and treatment of this rare complication. Herein, we report a unique case of early venous anastomosis avulsion following free DIEP flap transfer for delayed breast reconstruction. Venous outflow was successfully restored with the use of an interposition vein graft, and the flap survived completely. In addition, the relevant literature is reviewed; and the possible causes, preventive strategies, and management options are analyzed. © 2010 Wiley‐Liss, Inc. Microsurgery 2010.
Foot anomalies in the Late Neolithic/Chalcolithic population exhumed from the rock cut cave of São Paulo 2 (Almada, Portugal)
Authors: Silva A. M. 
Published: January 2010

AbstractThe study of developmental abnormalities of the tarsal bones in a Portuguese Late Neolithic population was performed, as part of an ongoing research project that includes the evaluation of foot defects in Portuguese skeletal populations from Neolithic times to modern 20th century samples. Two accessory bones were found, calcaneum secundarium and os trigonum, and three non‐osseous coalitions were detected, calcaneonavicular, cuboid‐navicular and third metatarsal‐third cuneiform. The newly presented frequencies corresponded to other published sources, except for the frequency of calcaneum secundarium, higher than in previous studies (8.6% left bones; 15.2% right bones). This result suggests population homogeneity maybe due to geographic isolation and/or marriage customs although the exact pattern of inheritance of the majority of these foot anomalies is unknown. No apparent sex bias was detected and side could not be tested since these human remains were uncovered from a commingled funerary context. Copyright © 2010 John Wiley & Sons, Ltd.
Pyrroline‐5‐carboxylate synthase and proline biosynthesis: From osmotolerance to rare metabolic disease
Authors: Pérez‐Arellano Isabel , Carmona‐Álvarez Francisco , Martínez Ana I. , Rodríguez‐Díaz Jesús , Cervera Javier 
Published: January 2010

AbstractPyrroline‐5‐carboxylate synthase (P5CS) is a bifunctional enzyme that exhibits glutamate kinase (GK) and γ‐glutamyl phosphate reductase (GPR) activities. The enzyme is highly relevant in humans because it belongs to a combined route for the interconversion of glutamate, ornithine and proline. The deficiency of P5CS activity in humans is associated with a rare, inherited metabolic disease. It is well established that some bacteria and plants accumulate proline in response to osmotic stress. The alignment of P5CSs from different species and analysis of the solved structures of GK and GPR reveal high sequence and structural conservation. The information acquired from different mutant enzymes with increased osmotolerant properties, together with the position of the insertion found in the longer human isoform, permit the delimitation of the regulatory site of GK and P5CS and the proposal of a model of P5CS architecture. Additionally, the GK moiety of the human enzyme has been modeled and the known clinical mutations and polymorphisms have been mapped.
Thermodynamic resolution: How do errors in modeled protein structures affect binding affinity predictions?
Authors: Singh Manoj Kumar , Dominy Brian N. 
Published: January 2010

AbstractThe present study addresses the effect of structural distortion, caused by protein modeling errors, on calculated binding affinities toward small molecules. The binding affinities to a total of 300 distorted structures based on five different protein–ligand complexes were evaluated to establish a broadly applicable relationship between errors in protein structure and errors in calculated binding affinities. Relatively accurate protein models (less than 2 Å RMSD within the binding site) demonstrate a 14.78 (±7.5)% deviation in binding affinity from that calculated by using the corresponding crystal structure. For structures of 2–3 Å, 3–4 Å, and >4 Å RMSD within the binding site, the error in calculated binding affinity increases to 20.8 (±5.98), 22.79 (±11.3), and 29.43 (±11.47)%, respectively. The results described here may be used in combination with other tools to evaluate the utility of modeled protein structures for drug development or other ligand‐binding studies. Proteins 2010. © 2010 Wiley‐Liss, Inc.
Significantly decreased production times for a‐Si/µc‐Si tandem cells on texture‐etched ZnO:Al
Authors: Gordijn A. , Schicho S. , Muthmann S. , Kilper T. , Zhu H. , Bunte E. , Hüpkes J. 
Published: January 2010

AbstractSeveral approaches that lead to shorter production times of a‐Si/µc‐Si tandem cells are combined in this paper: high‐rate sputtering of aluminum‐doped zinc oxide, high‐rate 40 MHz plasma deposition of microcrystalline silicon and reduced i‐layer thicknesses. On standard lab‐type texture‐etched ZnO:Al, 1 cm2 a‐Si:H/µc‐Si:H tandem test cells on a deposition area of 30 × 30 cm2 were made that showed an initial efficiency of 9.9%, whereas the total effective deposition time of intrinsic layers was only 22 min (15 min for the top cell and 7 min for the bottom cell). The silicon thickness is only 600 nm. On high‐rate texture‐etched ZnO:Al an efficiency of 9.4% initial was reached. Standard light‐induced degradation experiments showed a degradation rate of only 5.5–7.9% after 1000 h. This regime of very short preparation times and relatively high‐stabilized efficiencies is highly interesting from the production point‐of‐view.
Structural order on different length scales in amorphous silicon investigated by Raman spectroscopy
Authors: Muthmann S. , Köhler F. , Carius R. , Gordijn A. 
Published: January 2010

AbstractParameters for the structural short (SRO) and medium range order (MRO) of hydrogenated amorphous silicon (a‐Si:H) films on the edge of the microcrystalline silicon (µc‐Si:H) phase transition were studied with Raman spectroscopy. The observed samples were deposited using radio frequency plasma enhanced chemical vapor deposition. The studied films were grown with various constant and non‐constant silane concentrations (SCs). A substrate dependent correlation of SC to the intensity ratio (IMRO) of the transversal acoustical (TA) and the transversal optical (TO) phonon bands was found. A strong correlation between width and position of the (TO) phonon band was observed. These two easily accessible parameters show an increase of SRO when IMRO decreases.
Hydrogen distribution in the vicinity of dangling bonds in hydrogenated amorphous silicon (a‐Si:H)
Authors: Fehr M. , Schnegg A. , Teutloff C. , Bittl R. , Astakhov O. , Finger F. , Rech B. , Lips K. 
Published: January 2010

AbstractWe have investigated the distribution of H atoms around native dangling bonds in a‐Si:H by electron‐nuclear double resonance (ENDOR). In contrast to previous electron spin echo envelope modulation (ESEEM) studies [Isoya et al., Phys. Rev. B47(12), 7013–7024 (1993)] we find that the distance between H atoms and dangling‐bond defects can be well belowr = 3 Å. Our experimental data suggest that the H distribution is continuous and homogeneous and there is no indication for a short‐range order between H atoms and dangling bonds. This work is a first step toward the investigation of the H distribution around light‐induced defects to test models predicting the immediate proximity of H and defects.
A recombination model for a‐Si:H/c‐Si heterostructures
Authors: Leendertz C. , Stangl R. , Schulze T. F. , Schmidt M. , Korte L. 
Published: January 2010

AbstractA semi‐analytical model to describe the excess carrier concentration‐dependent recombination processes and the charge carrier lifetime in a‐Si:H/c‐Si heterostructures has been developed. In contrast to previously proposed models it accounts for most relevant physical processes: In addition to bulk recombination processes the recombination via distributed dangling bond defects at the interface is integrated. Furthermore interface band bending depending on the a‐Si:H doping and the Fermi‐level dependent defect charge is taken into consideration as well as charge carrier diffusion to the interface. Despite its complexity the model allows for rapid computation and is thus well suited for fitting lifetime measurements in order to extract interface parameters. The model is crosschecked for various experimentally relevant situations against the numerical simulation tool AFORS‐HET (© 2010 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)