bluuebunny/crossref_metadata_2025_split huggingface dataset:
Two‐ and three‐dimensional healing assessment after endodontic microsurgery in through‐and‐through periapical lesions: 5‐year follow‐up from a randomized controlled trial
Authors: Dhamija Ritika , Tewari Sanjay , Gupta Ambika 
Published: May 2024

AbstractAimTo evaluate clinical and radiographic outcome of endodontic microsurgery in through‐and‐through periapical lesions at 1‐year and 5‐year follow‐up with adjunct use of platelet‐rich plasma (PRP).MethodologyThirty‐two patients with large through‐and‐through periapical lesions were randomized in platelet‐rich plasma (PRP) group and control group. Two‐dimensional (2D) healing was evaluated with Molven's criteria and three‐dimensional (3D) healing with modified PENN 3D criteria. Healing at resection plane (R), apical area (A), buccal cortex (BC), palatal cortex (PC) and overall bone healing (B) was assessed using CBCT scans. The volume of lesion was measured using ITK‐Snap software. The analysis included comparison of 1‐ to 5‐year intragroup (Friedman test/McNemar test) and intergroup scoring (Chi‐square/ Mann–Whitney test). Logistic regression analysis was performed to determine the effect of various factors on healing at 5 years.ResultsOut of 32 patients/59 teeth evaluated after 1‐year of endodontic microsurgery, 24 patients/44 teeth reported at 5 ‐ year follow‐up. Healing assessment with modified PENN 3D criteria revealed improvement in overall success rate of 66.7% at 1 year to 83.3% at 5 years, with no deterioration in any healing category. PRP group exhibited significantly better 3D healing than control group; both at 1 year (84.6% vs. 45.5%) and 5 years (100% vs. 63.6%). A significantly higher number of completely healed teeth were observed in PRP group than the control group at 5 years with respect to R, BC and B parameters. A volume reduction of 88% (91.4% PRP, 84% control) was depicted at 1 year and 94% (97.1% PRP, 91.1% control) at 5 years. None of the recorded factors including age, gender, size of lesion, preoperative swelling and sinus, histology of lesion, use of PRP, tooth location, preoperative buccal bone had significant effect on 3D healing at 5 years.ConclusionsThis 5‐year study suggested improvement in 3D radiographic healing of large through‐and‐through periapical lesions from 1 to 5 years with no deterioration in any healing parameter in both control and PRP groups. The additional use of PRP led to significantly better healing in such lesions. RACB index using CBCT allows better estimation of healing at resected, apical and cortical plane over modified PENN 3D or Molven's criteria.
Enhanced ferroelectric properties in BiAlO3 modified lead‐free Mn‐doped Bi0.5(Na0.8K0.2)0.5TiO3 thin films
Authors: Peng Jinghui , Nie Hengchang , Yuan Yuou , Yong Xiao , He Biao , Wang Genshui , Du Fanglin , Shi Liang , Qu Xiaofei , Zhang Shuai 
Published: May 2024

AbstractMn‐doped (1‐x)Bi0.5(Na0.8K0.2)0.5TiO3‐xBiAlO3 (Mn:BNKT‐xBA) thin films were synthesized on lanthanum nickelate‐coated silicon substrates by sol‐gel method. The second phase issue of the film can be effectively addressed by optimizing the substrate, and the maximum polarization and breakdown strength can be increased by introducing the proper amount of Al3+, which is advantageous for the film for energy storage. The results have shown that the Mn:BNKT‐0.03BA film exhibits superior ferroelectric properties (with remanent polarization (Pr) of 23.72 µC/cm2, maximum polarization (Pmax) of 75.37 µC/cm2), which could be an excellent candidate for ferroelectric thin film capacitors.
Teachers’ perceptions of implementing digital multimodal composing in tertiary classrooms: Voices from Chinese EFL teachers
Authors: Zhang Yu , Peng Jing , Zheng Yao 
Published: May 2024

AbstractIn language education, digital multimodal composing (DMC) pertains to a new literacy practice in which students use digital tools to produce texts incorporating multiple semiotic modes. Despite that many scholars advocate for implementing DMC in language classrooms, it remains marginal in mainstream classrooms, with scant attention being paid to teachers’ perceptions concerning the use of DMC. Situated in Chinese universities, this research probes into the perspectives of five English teachers on implementing DMC as a pedagogical innovation. The analysis of data collected from multiple sources reveals that the teachers perceived DMC positively due to its affordances for students, namely, cultivating digital and multimodal literacies, improving speaking and writing abilities, fostering collaboration and communication skills, and enhancing learning interest and motivation. Teachers themselves harvested benefits regarding deeper insights into students’ learning potentials, enhanced digital literacies, a novel avenue for academic research, and an innovative teaching method. Nonetheless, the teachers expressed concerns about time constraints, students’ engagement in group work, potential plagiarism, assessment of students’ videos, and the long‐term effect of DMC on students’ writing performance. Based on the findings, this research provides implications for integrating curriculum innovations like DMC into conventional curricula.
Efficacy of apremilast in hyperkeratotic hand and foot dermatitis: results from a randomized observer‐blinded comparative study
Authors: Bhat Kriti , Patra Suman , Bhardwaj Abhishek , Singh Saurabh , Budania Anil , Bains Anupama , Saurabh Suman 
Published: May 2024

AbstractBackgroundHyperkeratotic hand and foot dermatitis significantly affects quality of life. Some patients respond suboptimally to topical corticosteroids and have multiple recurrences.ObjectiveOur aim was to compare the efficacy and safety profile of apremilast and topical corticosteroid versus corticosteroid alone in hyperkeratotic hand and foot dermatitis.MethodsThis randomized controlled study involved 77 patients treated for 3 months. Group A (39 patients) received mometasone furoate 0.1% cream with oral apremilast 30 mg twice daily, and Group B (38 patients) received mometasone alone. They were assessed monthly using the Hand Eczema Clinical Severity Index (HECSI) and Visual Analogue Scale (VAS) scores for pruritus. Investigator Global Assessment (IGA) and Quality of Life in Hand Eczema Questionnaire (QOLHEQ) were conducted at the end of 3 months.ResultsThe HECSI, VAS score, and QOLHEQ showed a significant decrease in both groups from baseline to the third month. Intergroup comparisons of HECSI failed to reach the significance level. When compared, patients receiving apremilast had significantly better improvement in the third month according to the Patient Global Assessment (PGA) and Investigator Global Assessment (IGA). They also had a smaller number of flares.ConclusionAdding apremilast to topical corticosteroid leads to better patient and physician‐perceived improvement and reduces the number of flares in hyperkeratotic hand eczema.
An alkali substrate feeding engineering conversion platform for hesperetin 7‐O‐glucoside biosynthesis
Authors: Wang Chunqing , Chen Liang , Wang Zhendong , Zhu Siming 
Published: May 2024

SummaryThe poor water solubility of flavonoids has always been a bottleneck restricting industrial production and application. The key problem of water‐solubility of flavonoids was solved by establishing an alkali substrate‐feeding engineering conversion platform using recombinant rhamnosidase. The results showed that the recombinant enzyme had α‐L‐rhamnosidase activity. Using this enzyme, four kinds of flavonoids such as hesperidin (HSD) were successfully hydrolyzed to products such as hesperetin 7‐O‐glucoside (HMG). Four key enzyme reaction conditions such as temperature, pH, feed rate and substrate specificity were investigated, and the optimum process parameters of the conversion platform were obtained. That was, under the conditions of temperature 50 °C, pH 6 and feeding speed 0.5 mL min−1, HSD conversion efficiency can reach 8.65 mg min−1. In addition, the changes in enzyme protein structure during basic feeding were elucidated by circular binary chromatography (CD) and fluorescence spectrum. The platform has the advantages of low cost, simple process, green environmental protection, high conversion rate and product purity. This method laid a solid foundation for the resource utilisation of flavonoid glycosides and industrial production.
Characterisation of wholegrain composite for pretzels: a comprehensive nutritional and functional analysis
Authors: Amin Sana , Pasha Imran , Amin Amina , Ahmed Farah , Aadil Rana Muhammad 
Published: May 2024

SummaryWholegrain composite flours are used for bakery products to enhance their nutritional value and to decrease the reliance on wheat importation as well as to ensure food security in most developing countries. This work aimed to optimise oat, maize, barley and wheat flour levels in the development of nutritionally enriched wholegrain pretzels. Composite flour blends were prepared by mechanical mixing of oat flour (OF), barley flour (BF), maize flour (MF) and wheat flour (WF) in the following proportion: WF (100%) (T0 – control), W:B (90:10) (T1), W:M (90:10) (T2), W:O (90:10) (T3), W:B:M:O (85:5:5:5) (T4), W:B:M:O (76:8:8:8) (T5) and W:B:M:O (70:10:10:10) (T6). Wholegrain composite flour mixes were analysed for their proximate composition and antioxidant properties. The fat, protein, ash and moisture content significantly changed (P < 0.05) in all treatments, while the fibre content increased. DPPH radical scavenging activity and total phenolic and flavonoid content showed significant changes compared to the control. A rapid visco analyser determined multigrain flour's rheological and pasting properties, and the values showed significant (P < 0.05) differences for peak viscosity, final viscosity and pasting temperature. The final product was analysed for proximate analysis, texture, colour and sensory evaluation. The increase in moisture, protein, fibre and ash content of the product was observed. Moisture, fat and fibre content of pretzels exhibited significant correlations (P < 0.05) with the sensory parameters. A grouping of the samples in function of the chemical and sensory characteristics was depicted from the principal component analysis. Texture and colour analysis showed significant differences (P < 0.05). Sensory evaluation results showed that the overall score for acceptability found for composite flour mix which contains 10% barley, 10% oat and 10% maize with wheat in a 30:70 ratio was accepted by the consumer. Consumption of wholegrain pretzels as snack food can contribute to a nutritious and balanced diet.
Co‐designing restrictive practice elimination: A systems thinking approach with mental health service users and practitioners in rural/regional Australia
Authors: Bennetts Stephanie L. , Pepin Genevieve , Moylan Steven , Carolin Renae , Forrester‐Bowling Tari , McLure James , Brown Andrew D. , Lucas James J. 
Published: May 2024

AbstractElimination of restrictive practices (physical/mechanical restraint and seclusion) from adult acute mental health care services has been demanded internationally for many decades. This study aimed to: (1) Identify priority issues in the elimination of and use of alternative approaches to restrictive practices (seclusion and physical/mechanical restraint) in rural/regional acute adult mental healthcare services, as told by mental healthcare service users and practitioners, (2) identify the community‐based, system‐level feedback loops that enhance or reduce the use of restrictive practices and viable alternatives and, (3) identify potential action areas to improve system structures to increase regional mental healthcare services' ability to eliminate restrictive practices and use alternative approaches. Group model building (GMB) workshops were held with a small group (n = 9) of mental healthcare practitioners and service users with lived experience of restrictive practice use. This participatory approach enables exploration and visual mapping of local structures causing behaviour patterns of practitioner and service user concern over time – in this case, the barriers, and enablers to alternative approaches to restrictive practices in adult acute mental healthcare services within the Geelong‐Barwon region. This is the first study that specifically applies GMB in the discussion of the elimination of restrictive practices in mental health in the non‐metropolitan regional/rural context. Participants identified four key priorities in relation to eliminating restrictive practices: (1) self‐advocacy, (2) continuity of care, (3) early intervention, and (4) safety for all. The study findings were distilled into a novel preliminary set of mental healthcare practitioner and service user action ideas.
Foot self‐care behaviour in primary care patients with diabetic foot ulcers: Structural equation modelling of psychological predictors
Authors: Zhu Xiaoli , Lee Eng Sing , Chan Frederick H. F. , Lim Phoebe X. H. , Chen Yee Chui , Griva Konstadina 
Published: May 2024

AbstractDiabetic foot ulcers (DFUs) are one of the most prevalent and costly diabetes complications, associated with diminished quality of life and poor prognosis. Management of DFUs relies heavily on patients' foot self‐care behaviour. This study aims to explore psychological determinants of this important behaviour among primary care patients. A total of 186 patients with active DFUs self‐reported their illness perception, diabetes distress, self‐efficacy, and foot self‐care behaviour. Structural equation modelling was performed to examine interrelationships among measured variables. The final model demonstrated satisfactory fit, CFI = 0.933, TLI = 0.913, RMSEA = 0.050, SRMR = 0.073, χ2(95) = 132.256 (p = 0.004), and explained 51.1% of the variance of foot self‐care. Illness threat perceptions (i.e., consequence, timeline, identity, concern, and emotion) had a direct positive effect on foot self‐care behaviours, but also indirectly decreased foot self‐care through increasing diabetes distress. Control perceptions (i.e., personal control, treatment control, and coherence) were not directly associated with foot self‐care behaviours, but indirectly improved foot self‐care by reducing diabetes distress and increasing foot care confidence. These findings suggest illness perceptions, diabetes distress, and self‐care confidence as modifiable predictors to be targeted in self‐management interventions for patients with DFUs.
Structure‐function integrated ZrO2–SiO2 nanocrystalline glass–ceramics achieved by in situ formation of amorphous carbon
Authors: Yu Wenjun , Lei Zihua , Zhang Xiaoyu , Zhang Qinzhao , Cheng Yongxing , Deng Ying , Li Yang , Song Junjie , Fu Le 
Published: May 2024

AbstractCeramics can be traditionally classified as structural and functional ones. However, the miniaturization and multi‐functionalization of various devices require ceramics to have both structural and functional properties. In this work, we aimed to develop structure‐function integrated ZrO2–SiO2 nanocrystalline glass–ceramics (NCGCs) by in situ formation of homogenously distributed amorphous carbon. By reducing the calcination temperature of carbon‐containing powder, organic carbon groups were partially retained in the powder and they transformed to amorphous carbon in the sintered NCGCs. At micrometer scale, the carbon was homogenously distributed in the NCGCs, avoiding the commonly encountered agglomeration problem of carbon fillers. The effects of carbon on the microstructure, mechanical properties, wear resistance, and dielectric properties of the NCGCs were investigated. Results showed that the in situ formed amorphous carbon was homogenously distributed in the ZrO2 nanocrystallites. Meanwhile, the amorphous carbon strongly bonded with the ZrO2–SiO2 NCGCs. Only a small amount of carbon was combusted even after annealing at 1000°C for 3 h. The formation of amorphous carbon led to an improvement of nanohardness and wear resistance of the NCGCs, while slightly reducing Young's modulus and flexural strength. The electromagnetic wave transmission performances were improved due to the formation of amorphous carbon. The current study paves a new way for developing structure‐function integrated glass–ceramics through in situ formation of carbon. The prepared structure‐function integrated ZrO2–SiO2 NCGCs have great potential to be used as radome and antenna windows of aerospace aircrafts that work in harsh environment.
Effect of early cryoballoon ablation on atrial fibrillation recurrence—A Danish nationwide register study
Authors: Hein Regitze , Riis‐Vestergaard Lise Da , Tønnesen Jacob , Zörner Christopher Ryan , Rasmussen Peter Vibe , Ruwald Martin Huth , Johannessen Arne , Worck René Husted , Hansen Jim , Middelfart Charlotte , Gislason Gunnar Hilmar , Hansen Morten Lock 
Published: May 2024

AbstractIntroductionCryoballoon ablation is a safe and efficient rhythm control strategy in atrial fibrillation (AF) patients. The impact of time from diagnosis to ablation is unclear. The aim of this study was to examine the impact of timing of first‐time cryoballoon ablation on AF recurrence in a nationwide cohort of AF patients.Methods and ResultsFrom nationwide registers, all AF patients ≥18 years of age who underwent first‐time AF cryoballoon ablation in Denmark from 2012 to 2018 were included. The AF patients were stratified by ablation timing: Early group (≤1 year after AF diagnosis), intermediate group (1–3 years after AF diagnosis), and late group (≥3 years after AF diagnosis). By adjusted Cox regression models, the effect of timing on AF recurrence was examined.This study included 1064 AF patients with a median age of 63 years. Most patients were male (66%) and had paroxysmal AF (67%). The 1‐year risk of AF recurrence increased from 31% in the early group to 41% and 44% in the intermediate and late group. The hazard ratios (95% confidence intervals) were 1.28 (0.95, 1.74) in the intermediate group and 1.42 (1.09, 1.86) in the late group when compared to the early group. Continuous diagnosis‐to‐ablation time seemed to have the greatest impact on AF recurrence within the first 2 years.ConclusionIn AF patients undergoing cryoballoon ablation, late timing of ablation was associated with a significantly higher AF recurrence rate when compared to early timing of ablation. These findings support early cryoballoon ablation to improve the outcomes after ablation.
Role of oxidative stress‐induced ferroptosis in cancer therapy
Authors: Li Keqing , Fan Chengjiang , Chen Jianing , Xu Xin , Lu Chuwei , Shao Hanjie , Xi Yang 
Published: May 2024

AbstractFerroptosis is a distinct mode of cell death, distinguishing itself from typical apoptosis by its reliance on the accumulation of iron ions and lipid peroxides. Cells manifest an imbalance between oxidative stress and antioxidant equilibrium during certain pathological contexts, such as tumours, resulting in oxidative stress. Notably, recent investigations propose that heightened intracellular reactive oxygen species (ROS) due to oxidative stress can heighten cellular susceptibility to ferroptosis inducers or expedite the onset of ferroptosis. Consequently, comprehending role of ROS in the initiation of ferroptosis has significance in elucidating disorders related to oxidative stress. Moreover, an exhaustive exploration into the mechanism and control of ferroptosis might offer novel targets for addressing specific tumour types. Within this context, our review delves into recent fundamental pathways and the molecular foundation of ferroptosis. Four classical ferroptotic molecular pathways are well characterized, namely, glutathione peroxidase 4‐centred molecular pathway, nuclear factor erythroid 2‐related factor 2 molecular pathway, mitochondrial molecular pathway, and mTOR‐dependent autophagy pathway. Furthermore, we seek to elucidate the regulatory contributions enacted by ROS. Additionally, we provide an overview of targeted medications targeting four molecular pathways implicated in ferroptosis and their potential clinical applications. Here, we review the role of ROS and oxidative stress in ferroptosis, and we discuss opportunities to use ferroptosis as a new strategy for cancer therapy and point out the current challenges persisting within the domain of ROS‐regulated anticancer drug research and development.
Phylogeographic patterns of Cyphocharax from trans‐Andean rivers and northward expansion to lower Central America (Teleostei, Curimatidae)
Authors: Melo Bruno F. , Conde‐Saldaña Cristhian C. , Villa‐Navarro Francisco A. , McMahan Caleb D. , Oliveira Claudio 
Published: May 2024

AbstractPhylogenetic analyses of mitochondrial and nuclear data of 31 specimens of Cyphocharax from trans‐Andean rivers support the presence of one lineage of Cyphocharax aspilos in Lago Maracaibo and three cryptic lineages of Cyphocharax magdalenae: (1) Cauca‐Magdalena and Ranchería, (2) León and Atrato, and (3) Chucunaque‐Tuira, Santa María, and Chiriquí basins of Central America. Results suggest that the Serranía del Perijá facilitated Late Miocene cladogenetic events, whereas post‐Isthmian C. magdalenae expansion was enabled by gene flow across the lower Magdalena valley and Central American lowlands. Time‐calibrated phylogenetics indicate that the C. magdalenae colonized lower Central America in the Pliocene (3.7 MYA; Ma), the divergence Atrato‐Magdalena occurred in Late Pliocene (3.0 Ma) and the split Ranchería‐Magdalena during the Middle Pleistocene (1.3 Ma). Updated geographic distribution data support the hypothesis that the Cordillera de Talamanca functions as a barrier to northward expansion of C. magdalenae in Central America.
Validation of a German version of the dementia screening questionnaire for individuals with intellectual disabilities (DSQIID‐G) in Down's syndrome
Authors: Nuebling G. , Wagemann O. , Deb S. , Wlasich E. , Loosli S. V. , Sandkühler K. , Stockbauer A. , Prix C. , Levin J. 
Published: May 2024

AbstractBackgroundPeople with Down's syndrome (DS) are at high risk of developing Alzheimer dementia (DS‐AD) due to a triplication of the amyloid precursor protein gene. While several tools to diagnose and screen for DS‐AD, such as the dementia screening questionnaire for individuals with intellectual disabilities (DSQIID), are available in English, validated German versions of such instruments are scarce.MethodsA German version of the DSQIID questionnaire (DSQIID‐G) was completed by caregivers before attending our specialist outpatient department for DS‐AD. All participants were assessed blind to DSQIID‐G scoring using clinical and neuropsychological examinations, including the Cambridge Examination for Mental Disorders of Older People with Down's Syndrome and Others with Intellectual Disabilities (CAMDEX‐DS). ICD‐10 and amyloid/tau/neurodegeneration (A/T/N) criteria were applied to detect and categorise cognitive decline.ResultsOf 86 participants, 43 (50%) showed evidence of cognitive decline. A definite diagnosis of DS‐AD was reached in 17 (19.8%) and mild cognitive impairment in seven (8.3%) participants. Secondary causes of cognitive decline were determined among 13 (15.1%) participants, and in six (7%) cases, the diagnosis remained unclassifiable due to co‐morbidities. Compared with cognitively stable individuals, participants with cognitive decline (n = 43) displayed higher DSQIID‐G total scores [median (range): 3 (0–21) vs. 19 (0–48), P < 0.001]. A total score of >7 provided a sensitivity of 0.94 against a specificity of 0.76, to discriminate DS‐AD and participants without cognitive decline according to ROC analysis. The convergent validity against the CAMDEX‐DS interview score was good (r = 0.74), and split‐half reliability (r = 0.96), internal consistency (Cronbach's α r = 0.96), test–retest reliability (r = 0.88) (n = 25) and interrater reliability (r = 0.81) (n = 31) were excellent.ConclusionsThe DSQIID‐G showed excellent psychometric properties, including concurrent and internal validity and reliability. The cut‐off value for screening was lower than in the original English validation study. For a screening instrument like DSQIID‐G, a lower cut‐off is preferable to increase case detection.