bluuebunny/crossref_metadata_2025_split huggingface dataset:
CAG Repeat Polymorphism in the Androgen Receptor Gene in Women with Rheumatoid Arthritis
Authors: DZIEDZIEJKO VIOLETTA , KURZAWSKI MATEUSZ , SAFRANOW KRZYSZTOF , OSSOWSKI ANDRZEJ , PIATEK JAROSLAW , PARAFINIUK MIROSLAW , CHLUBEK DARIUSZ , PAWLIK ANDRZEJ 
Published: November 2011

Objective.Rheumatoid arthritis (RA) is the most common chronic, autoimmune, inflammatory disease, with a genetic and hormonal background. The prevalence of women among patients with RA suggests the important role of sex hormones in the pathogenesis of RA. We examined the association between CAG repeat polymorphism in the androgen receptor (AR) gene and susceptibility to RA and its clinical features in white women.Methods.The study groups consisted of 325 female patients with RA and 238 female controls. CAG repeat polymorphism was determined using polymerase chain reaction and subsequent fragment analysis by capillary electrophoresis.Results.The number of CAG repeats in patients did not differ from that of controls (22.1 ± 2.9 vs 21.9 ± 2.9, respectively; p = 0.26), but the presence of articular erosions was associated with a lower number of repeats in the shorter allele of patients with RA (20.4 ± 2.2 vs 21.2 ± 2.4; p = 0.031). When alleles with < 22 CAG were classified as short (S) and those with ≥ 22 CAG as long (L), the age at diagnosis of RA was lower in women with S-S genotype in comparison to combined S-L + L-L genotypes (43.0 ± 14.6 yrs vs 47.6 ± 12.5 yrs; p = 0.021). In patients with the L-L genotype, the frequency of erosive disease (OR 0.45, 95% CI 0.25–0.80, p = 0.0085) and extraarticular manifestations (OR 0.50, 95% CI 0.26–0.98, p = 0.047) was lower in comparison to carriers of the S allele. In multivariate analysis, the L-L genotype was an independent factor associated with a lower risk of erosions (OR 0.44, 95% CI 0.22–0.90, p = 0.024).Conclusion.The results suggest the association of short AR (CAG)n alleles with earlier onset and a more aggressive course of RA.
La clinique actuelle des familles avec des s à lui ? Si c'est Eiguer
Authors: Eiguer Alberto 
Published: November 2011

Résumé « La clinique actuelle des familles avec des adolescents. » Ce travail examine certaines difficultés actuelles rencontrées par les familles qui ont des enfants adolescents, tout particulièrement la défaillance de la mythopoïèse et la perte du sens de la famille. Après la définition de ces problématiques, l’exposition de leurs caractéristiques et l’analyse de leur origine, l’auteur étudie la fonction du thérapeute dont l’importance se fait sentir aussi bien par ses interprétations que par sa sensibilité aux virtualités de l’intersubjectivité, dans laquelle il est à la fois spectateur et acteur, voire auteur. À la lumière d’un exemple clinique, on note que la TFP permet de retrouver les buts de la famille et ensuite de consolider son identité. Pour y parvenir, on n’exclut pas une redéfinition de la place des parents et des enfants ou la remise en cause des intentions souvent inconscientes qui animent leurs projets.
Des outils théoriques pour traiter la famille en adolescence
Authors: Loncan Anne 
Published: November 2011

Résumé « Des outils théoriques pour traiter la famille en adolescence. » L’auteur cerne les indices de l’impact familial de la crise adolescente, désormais étalée sur une longue durée. Elle développe ensuite des options théoriques à propos de la topologie de la psyché groupale familiale. Les principaux points retenus (liens intersubjectifs et enveloppes psychiques), reconsidérés à la lumière de l’adolescence, contribueront à former le cadre des thérapies familiales psychanalytiques. Ils seront utiles à prendre en compte aussi bien dans l’engagement des thérapies que pour en apprécier l’évolution. Cette optique est illustrée par une brève vignette clinique.
Familles en mal d'adolescence
Authors: Aubertel Françoise 
Published: November 2011

Résumé « Familles en mal d’adolescence. » Dans le bouleversement des équilibres et de l’organisation des liens familiaux au moment de l’adolescence, la thérapie familiale psychanalytique offre un soin spécifique permettant un réétayage et une reprise des modalités de fonctionnement groupales autorisant les processus d’individuation.
Des Esseintes, un héros en négatif, dernier maillon d'une chaîne pathologique perverse
Authors: Condamin Christine , Sauvage-Vieillard Anne-Claire 
Published: November 2011

Résumé « Des Esseintes, un héros en négatif, dernier maillon d’une chaîne pathologique perverse. À propos du roman À rebours de J.-K. Huysmans. » Des Esseintes, héros singulier du roman À rebours de Joris-Karl Huysmans, tente de créer un lieu propice à son mode de jouissance perverse, un environnement privé, régressif et esthétisé, pour pouvoir survivre. Dans cette solitude, il fait part de ses troubles pathologiques et de sa douleur psychique, de son vécu conscient et inconscient, mais aussi du fonctionnement intersubjectif et transgénérationnel de sa famille par l’intermédiaire de ses souvenirs, de ses fantasmes et de ses rêves. Il montre comment chacun a pu être à la fois acteur et victime d’un tissage pathologique imprégné de violentes transmissions inter et transgénérationnelles. L’auteur du roman, dont le personnage peut être un double, fait œuvre de création littéraire dans un processus de sublimation, parvenant à une véritable recherche stylistique au cœur de l’intime.
Ceux qui n'y vont pas
Authors: Bourlanges Jean-Louis 
Published: November 2011

Résumé L’article procède d’une démarche paradoxale : étudier des non-événements et retracer des non-candidatures. De 1965 à 2007, les élections présidentielles ont été presque toutes marquées par l’absence finale d’un ou plusieurs candidats attendus. L’auteur dresse ici une libre typologie de ces défections et distingue cinq profils majeurs de défaillants : les surnuméraires qui se contentent de déposer leurs cartes de visite, les contestataires qui refusent le système, les mandataires qui espèrent indûment que l’élection leur sera servie sur un plateau, les légataires qui cherchent à hériter mais ne veulent pas conquérir, et enfin les atrabilaires qui attendent chimériquement du mandat convoité un pouvoir idéal, total et parfait.
ColorPhylo: A Color Code to Accurately Display Taxonomic Classifications
Authors: Lespinats Sylvain , Fertil Bernard 
Published: November 2011

Color may be very useful to visualise complex data. As far as taxonomy is concerned, color may help observing various species’ characteristics in correlation with classification. However, choosing the number of subclasses to display is often a complex task: on the one hand, assigning a limited number of colors to taxa of interest hides the structure imbedded in the subtrees of the taxonomy; on the other hand, differentiating a high number of taxa by giving them specific colors, without considering the underlying taxonomy, may lead to unreadable results since relationships between displayed taxa would not be supported by the color code. In the present paper, an automatic color coding scheme is proposed to visualise the levels of taxonomic relationships displayed as overlay on any kind of data plot. To achieve this goal, a dimensionality reduction method allows displaying taxonomic “distances” onto a Euclidean two-dimensional space. The resulting map is projected onto a 2D color space (the Hue, Saturation, Brightness colorimetric space with brightness set to 1). Proximity in the taxonomic classification corresponds to proximity on the map and is therefore materialised by color proximity. As a result, each species is related to a color code showing its position in the taxonomic tree. The so called ColorPhylo displays taxonomic relationships intuitively and can be combined with any biological result. A Matlab version of ColorPhylo is available at http://sy.lespi.free.fr/ColorPhylo-homepage.html . Meanwhile, an ad-hoc distance in case of taxonomy with unknown edge lengths is proposed.
Effect of EDTA concentration on the physical and optical properties of Cds thin films
Authors: Prem kumar T. , Sankaranarayanan K. 
Published: November 2011

AbstractApplication of ethylenediamine tetraacetic acid (EDTA) in the chemical bath solution to enhance the physical and optical properties of chemical bath deposited CdS film was realised. The observed beneficial effect on the crystallisation of CdS crystallites in the bath solution followed by deposition on glass substrates reduces the amorphousity and enhances the crystallinity of the film. The optical transparency of the film attains a maximum of 80% over the wavelength range of 650–1100 nm for the film deposited from EDTA‐added solution having the concentration of 0.006 mol/L. Also, the observed intensity of the characteristic photoluminescence emission was found to be dependent on the concentration of EDTA in the bath solution. © 2011 Canadian Society for Chemical Engineering
Examination of CD26/DPPIV, p53, and PTEN expression in thyroid follicular adenoma
Authors: Miyake Yasuyuki , Aratake Yatsuki , Sakaguchi Takuya , Kiyoya Kazuaki , Kuribayashi Tadanobu , Marutsuka Kousuke , Ohno Eiji 
Published: November 2011

AbstractTumor cytology has proven to be inadequate for precise diagnosis of thyroid follicular adenoma. This suggests the need for a molecular approach for its diagnosis.Expression of CD26/DPPIV (dipeptidyl peptidas IV), p53, and PTEN was analyzed in smears or sections obtained from 19 patients with histologically proven thyroid follicular adenoma. Papanicolaou staining, CD26/DPPIV activity staining, and HE staining were performed and the specimens were observed morphologically. Immunohistochemical analysis using antibodies against p53 and PTEN was performed. Genetic mutation of PTEN exons was performed using the laser capture microdissection method.The nuclear area of the CD26/DPPIV‐positive cells was significantly larger than that of the CD26/DPPIV‐negative cells. p53 expression was not observed any specimen. PTEN expression was observed in 18 of 19 cases. DNA sequence analysis did not reveal mutations in exons 5–9 of PTEN in the immunohistochemically PTEN‐negative case.In accordance with our previous reports, we found that observation of concomitant CD26‐positive and PTEN‐negative status in cases of follicular adenoma suggests a state close to follicular carcinoma or progression to cancer, thus warranting careful follow‐up. Diagn. Cytopathol. 2012. © 2011 Wiley Periodicals, Inc.
Fractional anisotropy‐weighted front evolution algorithm for white matter tractography based on diffusion tensor imaging data
Authors: Darki Fahimeh , Oghabian Mohammad Ali , Ahmadian Alireza , Zadeh Hamid Soltanian , Zarei Mojtaba 
Published: November 2011

AbstractTractography is one of the most important applications of diffusion tensor imaging (DTI) which noninvasively reconstructs 3D trajectories of the white matter tracts. Because of the intravoxel orientation heterogeneity of DTI data, some of tractography algorithms are unable to follow the correct pathways after the crossing and branching regions. Front propagation techniques are efficient methods in tracking the crossing fibers. A key parameter influencing the performance of these algorithms is the cost function which is mainly based on the colinearity of tensors' eigenvectors. The effect of the eigenvalues on the anisotropy strength of tensor has not been previously addressed in the definition of the speed function. In this article, a new speed function, based on the effect of diffusion anisotropy and the colinearity of eigenvectors is proposed. The performance of the suggested method on fiber tracking and crossing fiber detection has been evaluated using synthetic datasets, and the feasibility of the proposed method was shown by fiber tracking implemented on real DTI data. © 2011 Wiley Periodicals, Inc. Int J Imaging Syst Technol, 21, 307–314, 2011
New fMRI analysis method for multiple stimuli using reference estimation
Authors: Kim Eunwoo , Han Yeji , Park Hyunwook 
Published: November 2011

AbstractThe stimulation paradigms of a functional MRI (fMRI) usually consist of one or more stimulations and a resting state in the block‐based and event‐related designs. To localize the activation areas in the human brain, each voxel is statistically analyzed using the fMRI data measured with the stimulation. The conventional method can be inefficient for experiments with multiple stimuli because of measuring the resting‐state signals repeatedly, causing redundancy in the scanning process. Although the phase mapping method can be applied to reduce the redundant resting‐state measurements, there are still limitations in the detection of regions activated by multiple stimuli and the periodic sequence of the multiple stimuli. In this article, a new fMRI data analysis method is presented that enables the detection of functional activations without the resting‐state images. This method estimates the reference signal from the signals acquired during multiple stimuli, and a random sequence and various durations of the multiple stimuli can be applied. Therefore, it can be used in the event‐related design as well as the block‐based design. The results of simulation and fMRI experiments show that the proposed method can correctly detect the activation regions of multiple stimuli, even for overlap regions, and can reduce the imaging time by skipping the resting‐state imaging. © 2011 Wiley Periodicals, Inc. Int J Imaging Syst Technol, 21, 315–322, 2011
New splitting algorithms for geometric transformations of digital images and their error analysis
Authors: Li Zi‐Cai , Chiang John Y. , Suen C. Y. 
Published: November 2011

AbstractFor digital images and patterns under the nonlinear geometric transformation, T: (ξ, η) → (x, y), this study develops the splitting algorithms (i.e., the pixel‐division algorithms) that divide a 2D pixel into N × N subpixels, where N is a positive integer chosen as N = 2
k(k ≥ 0) in practical computations. When the true intensity values of pixels are known, this method makes it easy to compute the true intensity errors. As true intensity values are often unknown, the proposed approaches can compute the sequential intensity errors based on the differences between the two approximate intensity values at N and N/2. This article proposes the new splitting–shooting method, new splitting integrating method, and their combination. These methods approximate results show that the true errors of pixel intensity are O(H), where H is the pixel size. Note that the algorithms in this article do not produce any sequential errors as N ≥ N0, where N0 (≥2) is an integer independent of N and H. This is a distinctive feature compared to our previous papers on this subject. The other distinct feature of this article is that the true error bound O(H) is well suited to images with all kinds of discontinuous intensity, including scattered pixels. © 2011 Wiley Periodicals, Inc. Int J Imaging Syst Technol, 21, 323–335, 2011
Application of morphological connected openings and levelings on magnetic resonance images of the brain
Authors: Mendiola‐Santibañez Jorge D. , Terol‐Villalobos Iván R. , Jiménez‐Sánchez Angélica R. , Gallegos‐Duarte Martín , Rodriguez‐Resendiz Juvenal , Santillan Israel 
Published: November 2011

AbstractIn this article, several advanced connected transformations from mathematical morphology for computational neuroanatomy applications are developed. In particular, brain is separated from the skull in MRI T1 using morphological connected openings. The use of connected transformations allow the preservation of regions, without introduce new information. As a result, the segmented brains preserve by complete information of the original images being more reliable for the specialist who deals with information such as white and gray matter. © 2011 Wiley Periodicals, Inc. Int J ImagingSyst Technol, 21, 336–348, 2011
Serum cytokine levels in patients with chronic hepatitis B according to lamivudine therapy
Authors: Park Younhee , Park Yongjung , Han Kwang‐Hyub , Kim Hyon‐Suk 
Published: November 2011

AbstractBackground: Cytokines are known to play critical roles in the pathogenesis of chronic hepatitis B (CHB). However, the relationship between cytokines and treatment responses to drugs for CHB is not clearly defined yet. We measured the serum cytokine levels of interleukin (IL)‐1α, IL‐1β, IL‐2, IL‐4, IL‐6, IL‐8, IL‐10, vascular endothelial growth factor, interferon‐γ, tumor necrosis factor‐ (TNF‐α), macrophage/monocyte chemotactic protein 1, and epidermal growth factor to elucidate the cytokine expression pattern according to the patients' responses to lamivudine. Methods: Fifty‐eight specimens from 27 CHB patients and 98 specimens from healthy individuals were tested for 12 kinds of cytokines. The patients were grouped as: before treatment, ongoing treatment, duringmaintaining remission, and patients with viral breakthrough owing to resistance against lamivudine. The Evidence Investigator (Randox, Antrim, UK), a protein chip analyzer, was used to quantify serum cytokines. Results: Among 12 cytokines, IL‐6, IL‐8, IL‐10, and TNF‐α were significantly elevated in patients with resistance against lamivudine compared with patients maintaining response. IL‐8, IL‐10, and TNF‐α levels also weak to moderate correlated with ALT and HBV‐DNA concentrations. Conclusions: Serum cytokine levels would reflect the pathological differences of the individual treatment phases and may become useful indices in monitoring the treatment response of CHB. J. Clin. Lab. Anal. 25:414–421, 2011. © 2011 Wiley Periodicals, Inc.
Influences of the El Niño Southern Oscillation and the Pacific Decadal Oscillation on the timing of the North American spring
Authors: McCabe Gregory J. , Ault Toby R. , Cook Benjamin I. , Betancourt Julio L. , Schwartz Mark D. 
Published: November 2011

AbstractDetrended, modelled first leaf dates for 856 sites across North America for the period 1900–2008 are used to examine how the El Niño Southern Oscillation (ENSO) and the Pacific Decadal Oscillation (PDO) separately and together might influence the timing of spring. Although spring (mean March through April) ENSO and PDO signals are apparent in first leaf dates, the signals are not statistically significant (at a 95% confidence level (p < 0.05)) for most sites. The most significant ENSO/PDO signal in first leaf dates occurs for El Niño and positive PDO conditions. An analysis of the spatial distributions of first leaf dates for separate and combined ENSO/PDO conditions features a northwest–southeast dipole that is significantly (at p < 0.05) different than the distributions for neutral conditions. The nature of the teleconnection between Pacific SST's and first leaf dates is evident in comparable composites for detrended sea level pressure (SLP) in the spring months. During positive ENSO/PDO, there is an anomalous flow of warm air from the southwestern US into the northwestern US and an anomalous northeasterly flow of cold air from polar regions into the eastern and southeastern US. These flow patterns are reversed during negative ENSO/PDO. Although the magnitudes of first leaf date departures are not necessarily significantly related to ENSO and PDO, the spatial patterns of departures are significantly related to ENSO and PDO. These significant relations and the long‐lived persistence of SSTs provide a potential tool for forecasting the tendencies for first leaf dates to be early or late. Copyright © 2011 Royal Meteorological Society
VEGF expression in residual tumor cells in orbital retinoblastoma (IRSS stage III) treated with NACT: A prospective study
Authors: Radhakrishnan Venkatraman , Kashyap Seema , Singh Lata , Bakhshi Sameer 
Published: November 2011

AbstractWe prospectively evaluated vascular endothelial growth factor (VEGF) expression by immunohistochemistry in 22 consecutive IRSS stage III retinoblastoma patients who underwent enucleation after neoadjuvant chemotherapy (NACT). Positive VEGF expression was observed in 6/22 (27.3%) patients. VEGF expression was associated with local progression on MRI prior to enucleation (P = 0.004), pathological scleral (P = 0.023), and extra‐scleral tumor extension (P = 0.009). EFS for VEGF positive and negative patients was 0% and 56.25%, respectively (P = 0.0002). OS for VEGF positive patients was 33.33% and 54.69% for VEGF negative patients (P = 0.207). Thus, VEGF in residual tumor cells post‐NACT may represent poor response to NACT, potential for local invasion, and inferior outcome. Pediatr Blood Cancer 2012;59:567–569. © 2011 Wiley Periodicals, Inc.
Rheological properties and irreversible dispersion changes in carbon nanotube/epoxy systems
Authors: Schulz Sonja Carolin , Schlutter Jana , Buschhorn Samuel T. , Schulte Karl , Bauhofer Wolfgang 
Published: November 2011

AbstractWe report on the rheological properties of semidilute carbon nanotube (CNT)/epoxy suspensions with varying filler content prepared with different dispersion methods. We show that dispersion techniques can be distinguished by means of the rheological response. It was found that the suspensions undergo a lasting dispersion changes during the first shear sweep measurement. Shear‐induced changes within the suspension can also be visualized optically. Our results demonstrate that the rheological properties are strongly influenced by the measurement procedure, which has to be known in order to guarantee reproducible and comparable results. Finally, it does not seem possible to completely reset the sample history by shear treatment. POLYM. ENG. SCI., 2011. ©2011 Society of Plastics Engineers
Visual observation and numerical studies of N2 vs. CO2 foaming behavior in core‐back foam injection molding
Authors: Ishikawa Takeshi , Taki Kentaro , Ohshima Masahiro 
Published: November 2011

AbstractWe investigated, by visual observation and numerical calculations, the foaming behavior of polypropylene within a foam injection mold cavity with the environmentally benign physical blowing agents nitrogen (N2) and carbon dioxide (CO2). An 85‐ton core‐back injection‐molding machine with temperature and pressure monitoring systems as well as a high‐pressure view cell was used for the investigation. The experiments showed a prominent difference in bubble nucleation and growth between N2 and CO2 injection foaming. Even when the weight concentration of N2 dissolved in polymer was one‐third that of CO2, N2 injection foaming provided a bubble number density that was 30 times larger and a bubble size that was one‐third smaller compared to CO2 injection foaming. Classical bubble nucleation and growth models developed for batch foaming were employed to analyze these experimental results. The models reasonably explained the differences in injection foaming behavior between N2 and CO2. It was clearly demonstrated by both experiments and numerical calculations that N2 provides a higher number of bubbles with a smaller bubble size in foam injection molding compared to CO2 as a result of the lower solubility of N2 in the polymer and the larger degree of super‐saturation. POLYM. ENG. SCI., 2011. ©2011 Society of Plastics Engineers