bluuebunny/crossref_metadata_2025_split huggingface dataset:
Poor compliance with antifungal drug use guidelines by transplant physicians: a framework for educational guidelines and an international consensus on patient safety
Authors: Muñoz Patricia , Rojas Loreto , Cervera Carlos , Garrido Gregorio , Fariñas Maria Carmen , Valerio Maricela , Giannella Maddalena , Bouza Emilio ,   on behalf of the COMIT Study Group
Published: February 2011

Muñoz P, Rojas L, Cervera C, Garrido G, Fariñas MCarmen, Valerio M, Giannella M, Bouza E. Poor compliance with antifungal drug use guidelines by transplant physicians: a framework for educational guidelines and an international consensus on patient safety.  Clin Transplant 2012: 26: 87–96.  © 2011 John Wiley & Sons A/S.Abstract:  The rate of compliance with antifungal drug use guidelines by transplant physicians is mostly unknown. We performed a nationwide electronic survey to assess antifungal use by different types of transplant physicians.Sixty‐one percent (53/87) of the transplant programs responded (accounting for 85% of heart transplant procedures, 65% of kidney transplantations, and 71.5% of liver transplantations). Antifungal prophylaxis was used in 41.5% programs (liver 93.3%, heart 30.8%, and kidney 16%). Prophylaxis was universal in 32% of the programs and targeted only to selected patients in 68%, mainly indicated after re‐transplantation (73.3%), re‐intervention (66.7%) and hemodialysis (60%). Main drugs for universal prophylaxis were fluconazole and itraconazole (42.9% each), while fluconazole (60%), L‐amphotericin B (AMB), and caspofungin (13.4% each) were preferred for targeted prophylaxis. Overall, 84.9% of the programs used galactomannan for the diagnosis of invasive aspergillosis (only 34% in BAL) and 66.6% used voriconazole as first‐line monotherapy. Combination first‐line therapy for invasive aspergillosis was used by 31.3%, mainly with voriconazole with caspofungin (40%) or anidulafungin (26.7%) or L‐AMB‐caspofungin (26.7%).Adherence of transplant physicians to current recommendations on antifungal treatment and prophylaxis is poor. An international consensus that responds to differences in patients and centers and emphasizes patient safety is clearly needed.
Dietary docosahexaenoic acid in combination with arachidonic acid ameliorates allergen‐induced dermatitis in mice
Authors: Weise Christin , Heunemann Carolin , Loddenkemper Christoph , Herz Udo , van Tol Eric A.F. , Worm Margitta 
Published: February 2011

To cite this article: Weise C, Heunemann C, Loddenkemper C, Herz U, van Tol EAF, Worm M. Dietary docosahexaenoic acid in combination with arachidonic acid ameliorates allergen‐induced dermatitis in mice. Pediatr Allergy Immunol 2011; 22: 497–504.AbstractObjective:  In this study, we investigated the impact of dietary docosahexaenoic (DHA) and arachidonic acid (AA) on development and severity of allergen‐induced dermatitis.Study design:  In sensitized mice, skin inflammation was induced by ovalbumin. Mice received either a diet containing 0.015% DHA, 0.029% AA or the combination of both. The severity of dermatitis was evaluated by using a clinical skin score (CSS), followed by immunohistologic and cytokine analysis. To unravel potential mechanisms, interleukin (IL)‐4 or tumor necrosis factor α–stimulated keratinocytes from the cell line Kera‐308 was cultured with different DHA/AA compositions and analyzed regarding proliferation and cytokine production.Results:  Dietary DHA/AA significantly improved the severity of allergen‐induced dermatitis as the CSS was reduced by 36 ± 23% (p = 0.005). Furthermore, reduced epidermal KI67 expression, increased number of forkhead box P3+ cells, and elevated IL‐10 expression were determined in skin lesions of dietary‐treated mice. Correspondingly, in vitro DHA/AA‐treated keratinocytes exhibited increased IL‐10 expression and produced less thymic stromal lymphopoietin.Conclusion:  Dietary DHA/AA supplementation leads to a significant amelioration of allergen‐induced dermatitis. This was accompanied with the presence of increased regulatory T cells and IL‐10 expression in lesional skin. Moreover, we identify keratinocytes, which play a crucial role in the regulation of skin inflammation, as important targets of DHA/AA supplementation. Future studies are needed to clarify whether DHA/AA acts directly or whether its biologic active metabolites are responsible for these findings. This may unravel novel therapeutical compounds for allergen‐induced dermatitis.
The fishery for Antarctic krill – recent developments
Authors: Nicol Stephen , Foster Jacqueline , Kawaguchi So 
Published: February 2011

AbstractThe fishery for Antarctic krill (Euphausia superba) is the largest by tonnage in the Southern Ocean. The catch remained relatively stable at around 120 000 tonnes for 17 years until 2009, but has recently increased to more than 200 000 tonnes. The Commission for the Conservation of Antarctic Marine Living Resources precautionary catch limits for this species total over 8.6 million tonnes so it remains one of the ocean’s largest known underexploited stocks. Recent developments in harvesting technology and in products being derived from krill indicate renewed interest in exploiting this resource. At the same time, there are changes in the Southern Ocean environment that are affecting both krill and the fishery. This paper summarizes the current state of this fishery and highlights the changes that are affecting it.
The determinants of debt maturity in Australian firms
Authors: Alcock Jamie , Finn Frank , Tan Kelvin Jui Keng 
Published: February 2011

AbstractWe examine the determinants of debt maturity in the Australian capital market with the Top 400 firms listed on the Australian Securities Exchange for the period 1989–2006. We find that Australian firms not only exhibit a positive leverage–maturity relationship but also use short‐term debt to signal their high quality to the market. Our results are robust to different estimation methods that control for endogeneity and error‐dependence. We also find that ignoring the interaction between leverage and maturity can lead to erroneous conclusions about the support for the matching principle, the agency costs hypothesis and the transaction costs hypothesis.
Systematic liquidity risk and stock price reaction to shocks
Authors: Mazouz Khelifa , Alrabadi Dima W. H. , Yin Shuxing 
Published: February 2011

AbstractThis study examines the relationship between systematic liquidity risk and stock price reaction to large 1‐day price changes (or shocks). We base our analysis on a yearly updated constituents list of the FTSE All share index. Our overall results are consistent with the price continuation hypothesis, which suggests that positive (negative) shocks will be followed by positive (negative) abnormal returns. However, further analysis indicates that stocks with low systematic liquidity risk react efficiently to both positive and negative shocks, whereas stocks with high systematic liquidity risk underreact to both positive and negative shocks. Our results are valid irrespective of various robustness tests such as size of the shock, size of the firm, month‐of‐the‐year and day‐of‐the‐week effects. We conclude that trading on price patterns following shocks may not be profitable, as it involves taking substantial liquidity exposure.
Toward a Cognitive View of Trait Mindfulness: Distinct Cognitive Skills Predict Its Observing and Nonreactivity Facets
Authors: Anicha Cali L. , Ode Scott , Moeller Sara K. , Robinson Michael D. 
Published: February 2011

AbstractDispositional variations in mindfulness and its facets have garnered considerable recent interest in the clinical and personality literatures. Theoretically, high mindful individuals have been characterized as more attuned to momentary sensations and perceptions and/or better able to execute behavior in a controlled manner, yet data of this relatively cognitive type have not been reported. In addition, perceptual attunement and executive control are distinct skills that may underlie, or at least correlate with, distinct facets of mindfulness. In 3 studies involving college students (N = 297), support for the latter idea was found. Individuals high in the observing (but not nonreactivity) facet of mindfulness demonstrated superior perceptual abilities in visual working memory (Study 1) and temporal order (Study 2) tasks. On the other hand, individuals high in the nonreactivity (but not observing) facet of mindfulness exhibited greater cognitive control flexibility (Study 3). Implications for understanding the cognitive basis of mindfulness facets are discussed.
Five‐Factor Personality Traits and Age Trajectories of Self‐Rated Health: The Role of Question Framing
Authors: Löckenhoff Corinna E. , Terracciano Antonio , Ferrucci Luigi , Costa Paul T. 
Published: February 2011

AbstractWe examined the influence of personality traits on mean levels and age trends in 4 single‐item measures of self‐rated health: general rating, comparison to age peers, comparison to past health, and expectations for future health. Community‐dwelling participants (N = 1,683) completed 7,474 self‐rated health assessments over a period of up to 19 years. In hierarchical linear modeling analyses, age‐associated declines differed across the 4 health items. Across age groups, high Neuroticism and low Conscientiousness, low Extraversion, and low Openness were associated with worse health ratings, with notable differences across the 4 health items. Furthermore, high Neuroticism predicted steeper declines in health ratings involving temporal comparisons. We consider theoretical implications regarding the mechanisms behind associations among personality traits and self‐rated health.
The Disguise of Sobriety: Unveiled by Alcohol in Persons With an Aggressive Personality
Authors: Giancola Peter R. , Parrott Dominic J. , Silvia Paul J. , DeWall C. Nathan , Bègue Laurent , Subra Baptiste , Duke Aaron A. , Bushman Brad J. 
Published: February 2011

AbstractThis investigation examined the factor structure of 8 well‐validated self‐report measures that assess traits that fall under the rubric of an “aggressive personality” and then determined how those factor(s) moderated the association between alcohol intoxication and aggression. Participants were 518 (252 men and 266 women) healthy social drinkers between 21 and 35 years of age. Following the consumption of an alcoholic or a placebo beverage, participants were tested on a laboratory aggression paradigm in which electric shocks were received from, and administered to, a fictitious opponent. Aggression was operationalized as the shock intensities and durations administered to the opponent. Results demonstrated a unidimensional factor structure for the aggressive personality traits, which were then combined into a latent variable. The aggressive personality variable moderated the alcohol‐aggression relation. Specifically, alcohol was significantly more likely to increase aggression in persons with higher, compared with lower, aggressive personality scores.
The Role of Scripts in Personal Consistency and Individual Differences
Authors: Demorest Amy , Popovska Ana , Dabova Milena 
Published: February 2011

AbstractThis article examines the role of scripts in personal consistency and individual differences. Scripts are personally distinctive rules for understanding emotionally significant experiences. In 2 studies, scripts were identified from autobiographical memories of college students (Ns = 47 and 50) using standard categories of events and emotions to derive event‐emotion compounds (e.g., Affiliation‐Joy). In Study 1, scripts predicted responses to a reaction‐time task 1 month later, such that participants responded more quickly to the event from their script when asked to indicate what emotion would be evoked by a series of events. In Study 2, individual differences in 5 common scripts were found to be systematically related to individual differences in traits of the Five‐Factor Model. Distinct patterns of correlation revealed the importance of studying events and emotions in compound units, that is, in script form (e.g., Agreeableness was correlated with the script Affiliation‐Joy but not with the scripts Fun‐Joy or Affiliation‐Love).
Body work in respiratory physiological examinations
Authors: Måseide Per 
Published: February 2011

AbstractThis article focuses on respiratory physiological examinations conducted in the respiratory physiological lab of a Norwegian hospital ward. The examinations were aimed at producing exact and objective measures of patients’ respiratory functions or capacities. The quality of the examinations depended on correct use of technology and adequate body work by professionals and patients. The concept of ‘body work’ has several meanings. The professionals’ body work was not direct hands‐on work. Their contact with the patient was communicative and informed or guided by technical devices. Although the patient’s objective body constituted the focus of examination, it necessitated an active and compliant patient. The concrete outcome of the examination was a textual artefact that in the examination situation counted as the accurate and objective representation of the patient’s respiratory physiological status. These examinations represented a mutually constitutive process between various agents, bodies and bodily modes required for and aimed at by the examination; different articulations of body work were essential for these processes. The objective of the article is to examine the kinds of body work that are conducted, paying particular attention to the conceptions of bodies that are practically generated during these examinations.
AIRPORT CONGESTION PRICING AND ITS WELFARE IMPLICATIONS: THE CASE OF VARIABLE PASSENGER TIME COSTS
Authors: Yuen Andrew C. L. , Zhang Anming 
Published: February 2011

AbstractThis paper develops an analytical framework for airport congestion pricing by considering variable passenger time costs. We find that, first, congestion delays will not be fully internalized at the carrier level under different market structures, including those airports dominated by a monopoly airline. Therefore, congestion pricing is necessary regardless of the market structures. Second, although congestion pricing is welfare‐improving, it may not be Pareto‐improving. This might explain why congestion pricing is unpopular in the real world.
NOTE ON THE PRODUCTIVITY CONVERGENCE OF AIRPORTS IN CHINA
Authors: Fung Michael Ka Yiu , Chow Clement Kong Wing 
Published: February 2011

AbstractThe present paper uses a Malmquist index measure of productivity growth to study the productivity convergence of 25 airports in China during the period 1995–2004. By decomposing the Malmquist index, we find evidence for the convergence of the efficiency level of airports, but not the productivity and technology levels. These results imply that the more productive airports are pushing the frontiers of technology faster by adopting new technology, and that the relative efficiency level of the laggards increases quickly and catches up with the efficiency level of the leaders over time.
An Empirical Analysis of the Effect of Financial Education on Graduating Business Students’ Perceptions of Their Retirement Planning Familiarity, Motivation, and Preparedness
Authors: Power Mark L. , Hobbs Jonathan M. , Ober Ashley 
Published: February 2011

AbstractToday's multifaceted and dynamic financial environment requires a high level of individual financial literacy to ensure that sound financial behaviors are the norm. Unfortunately, many individuals have limited knowledge regarding financial issues and are ill prepared to make sound financial choices. The purpose of this article was to benchmark and then determine if graduating business students’ perception of their retirement planning familiarity, motivation, and preparedness improved after taking a semester‐long course in Personal Risk Management and Insurance (PRMI). We discovered that business students were more financially literate than nonbusiness students and that business students’ familiarity with retirement plans and personal level of readiness to make retirement planning decisions improved significantly after taking the principles class. Specifically, we showed that only 15.8 percent and 42.3 percent of the nonbusiness and business control students, respectively, felt adequately prepared to make retirement decisions, while 82 percent of the business students who completed the PRMI class felt prepared. Ex post, graduating seniors who were exposed to coursework covering life‐cycle risks and options to treat those risks perceived that they are leaving college with a better ability to meet the financial challenges that await them. Last, we showed that significant differences existed in retirement plan and investment familiarity based on gender. Our findings provide support for including financial literacy as a general education requirement at colleges and universities.
Empirical Evidence on the Value of Group‐Level Financial Information in Insurer Solvency Surveillance
Authors: Pottier Steven W. , Sommer David W. 
Published: February 2011

AbstractThe existing empirical research on insurer insolvency relies almost exclusively upon individual insurance company financial data, even though the insurance industry is dominated by group‐affiliated firms. This is the first study to evaluate the benefit of using group‐level data to predict insurer insolvencies for group‐affiliated insurers. The study uses financial ratios from the NAIC FAST scoring system, measured at both the company level and group level, as potential predictor variables. The results indicate that group‐level financial information substantially improves the predictive power of an insolvency prediction model relative to a model that uses only the analogous company‐level variables. In fact, the group‐level variables are found to often be substantially more powerful than company‐level variables in predicting individual insurer insolvencies. These results suggest that future insolvency analysis should, whenever feasible, include group‐level information to obtain higher predictive accuracy.
The 7‐year course of depression and anxiety in the general population
Authors: Rhebergen D. , Batelaan N. M. , de Graaf R. , Nolen W. A. , Spijker J. , Beekman A. T. F. , Penninx B. W. J. H. 
Published: February 2011

Rhebergen D, Batelaan NM, de Graaf R, Nolen WA, Spijker J, Beekman ATF, Penninx BWJH. The 7‐year course of depression and anxiety in the general population.Objective:  Insight into the long‐term course of depression and anxiety.Method:  Data were derived from Netherlands Mental Health Survey and Incidence Study/Netherlands Study of Depression and Anxiety, epidemiologic surveys in the adult population in the Netherlands. Three hundred and three respondents with depressive and/or anxiety Composite International Diagnostic Interview (CIDI) disorder were interviewed, examining the 7‐year course of depression (n = 141), anxiety (n = 102) and the comorbid state (n = 60) and possible prognostic factors. Outcomes were CIDI diagnostic status after 7 years and percentage of time during 7 years with depressive and/or anxiety symptoms, retrospectively assessed by the Life Chart Interview (LCI).Results:  After 7 years, 60.7% of the subjects were free from a 12‐month CIDI depression or anxiety diagnosis. The odds were higher for subjects with anxiety and comorbidity compared to subjects with depression. Low physical functioning and high neuroticism predicted the presence of a diagnosis after 7 years.During 7‐year follow‐up, 37.3% of the subjects were free from depressive and anxiety symptoms according to the LCI, 51.8% had symptoms <50% of the time, and 10.9%≥50% of the time. (Comorbid) anxiety resulted in a poorer course. High neuroticism and childhood adversity predicted more follow‐up time with symptoms.Conclusion:  Course trajectories were more favorable than expected, although comorbidity resulted in poorer course. Neuroticism, physical functioning, and childhood adversity predicted an unfavorable course.
From children to young adults: cystic fibrosis and siblingship A longitudinal study
Authors: Wennström I‐L , Isberg P‐E , Wirtberg I , Rydén O 
Published: February 2011

AbstractAim:  To compare the results from our previous study in 1994/95 of children with cystic fibrosis (CF) at the age of 6–14 years and their healthy siblings with data from the same participants as young adults in regard to their self‐esteem, life satisfaction and attitudes towards the CF siblingship situation.Methods:  Thirty‐seven sibling pairs participated. Three instruments were used: The ‘As I see myself’ self‐evaluation questionnaire; the ‘Ladder of life’, assessing life satisfaction; and the ‘Sibling Mirror’, reflecting a person’s feelings, when one’s sibling or oneself has CF.Results:  Contrary to 1994/95 study results, the female participants showed no signs of impaired self‐esteem. Concerning life satisfaction, women in both groups and the men with CF have lower ratings than a healthy reference group. Individuals with CF look upon themselves today as independent, thoughtful and mature, but remember themselves as being active, spoiled or fussy. Healthy siblings consider themselves diplomatic, responsible, mature, important and loyal but remember themselves as angry, envious and neglected.Conclusion:  The self‐esteem of women in the sibling pairs (whether with CF or healthy sisters) has improved since their childhood. Overall, the results indicate that young adults with CF today are medically well controlled and psychosocially well adapted, albeit aware of their precarious future.
Breastfeeding and early child development: a prospective cohort study
Authors: Oddy Wendy H. , Robinson Monique , Kendall Garth E. , Li Jianghong , Zubrick Stephen R. , Stanley Fiona J. 
Published: February 2011

AbstractAim:  Breastfeeding has been associated with multiple developmental advantages for the infant; however, there have also been a number of studies that find no significant benefits to child development. We examined the relationship between breastfeeding for 4 months or longer and child development at age 1, 2 and 3 years.Methods:  Women were enrolled in the Western Australian Pregnancy Cohort (Raine) Study (N = 2900) and their live born children (N = 2868) were followed to the age of 3 years (N = 2280). Infant feeding data were collected at each age, and the mothers completed the Infant/Child Monitoring Questionnaire (IMQ), which measures progress towards developmental milestones in the domains of gross and fine motor skills, adaptability, sociability and communication. Factors adjusted for in multivariable analyses included maternal sociodemographic characteristics and stressful life events.Results:  Infants breastfed for 4 months or longer had significantly higher mean scores (representing better functioning) for fine motor skills at age 1 and 3, significantly higher adaptability scores up to age two, and higher communication scores at age 1 and 3 years. Infants who were breastfed for <4 months were more likely to have at least one atypical score across the five developmental domains than those who were breastfed for 4 months or longer.Conclusion:  Although our effect sizes were small, breastfeeding for 4 months or longer was associated with improved developmental outcomes for children aged one to 3 years after adjustment for multiple confounding factors.