bluuebunny/crossref_metadata_2025_split huggingface dataset:
The investigation into indomethacin‐induced potentiation of the contractile response to antigen in ovalbumin‐sensitized guinea‐pig tracheas
Authors: Bozkurt Turgut Emrah , Sahin‐Erdemli Inci , Ilhan Mustafa 
Published: January 2011

AbstractIn the present study, we investigated the mediators involved in the potentiation of antigen‐induced contractions by indomethacin in tracheas isolated from ovalbumin (OA)‐sensitized guinea‐pigs. Indomethacin‐induced potentiation of OA contraction was mimicked by prostaglandin DP/EP1/EP2receptor antagonist, AH‐6809 but not by phospholipase A2enzyme inhibitor mepacrine. The lipoxygenase inhibitor AA‐861 did not affect the contraction response to OA but prevented its potentiation by indomethacin, while the leukotriene receptor antagonist cinalukast inhibited both the OA response and its potentiation. However, the antagonists of platelet‐activating factor (PAF) (BN‐52021), adenosine (CGS‐15943), endothelin ETAand ETBreceptors (BQ‐123, BQ‐788), and the neutral endopeptidase inhibitor phosphoramidon did not alter the OA‐induced contraction and its potentiation by indomethacin. Furthermore, capsaicin and neuropeptide receptor NK1, NK2, and NK3 antagonists (L‐732128, MEN‐10376, and SB‐218795, respectively) also did not affect the OA‐induced contractions and its potentiation. On the other hand, the ‘transient receptor potential vanilloid 1’ (TRPV1) antagonist capsazepine inhibited the potentiation response, while it did not alter the OA contraction itself. In conclusion, the potentiation of OA‐induced contraction by indomethacin is more likely due to the increase in lipoxygenase products by the shift of arachidonic acid towards lipoxygenase pathway. Because some of the lipoxygenase products are potent vanilloid agonists, the stimulation of TRPV1 receptors besides leukotriene receptors seems to participate in the potentiation of contraction response in sensitized guinea‐pig tracheas. PAF, adenosine, endothelins, and the neuropeptides present in the afferent neurons do not contribute to the potentiation of OA‐induced contraction by indomethacin.
Treatment of primary immune‐mediated hemolytic anemia with mycophenolate mofetil in two cats
Authors: Bacek Lenore M. , Macintire Douglass K. 
Published: January 2011

AbstractObjective –To describe the use of oral mycophenolate mofetil (MMF) as an adjunctive therapy in 2 cats with primary immune‐mediated hemolytic anemia.Case Series Summary –Two cats suffering from presumptive primary immune mediated hemolytic were treated with MMF as part of their treatment regimens. Both cats had improved complete blood counts following therapy.New or Unique Information Provided –This is the first reported use of oral MMF as adjunctive treatment for cats with immune‐mediated hemolytic anemia. Outcome was favorable in both cats and no adverse effects were noted from the MMF.
Evaluation of gastric pressures as an indirect method for measurement of intraabdominal pressures in the horse
Authors: Munsterman Amelia S. , Hanson Russell Reid 
Published: January 2011

AbstractObjective
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To develop an indirect method for measurement of intraabdominal pressures in the standing horse using measurement of gastric pressures as a less invasive technique, and to compare this method with direct intraabdominal pressures obtained from the peritoneal cavity.Design
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Prospective, experimental study.Setting
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University‐based equine research facility.Animals
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Ten healthy adult horses, 7 geldings and 3 mares.Interventions
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Gastric pressures were measured using a nasogastric tube with a U‐tube manometry technique, while intraperitoneal pressures were measured with a peritoneal cannula. Measurements of intraabdominal pressure were obtained by both methods, simultaneously, and were evaluated using 5 increasing volumes of fluid infused into the stomach (0, 400, 1,000, 2,000, and 3,000 mL). Bias and agreement between the 2 methods were determined using Bland‐Altman analysis and Lin's concordance correlation coefficients.Measurements and Main Results
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Mean gastric pressure was 14.44±4.69 cm H2O and ranged from 0 to 25.8 cm H2O. Intraperitoneal pressure measurements were generally subatmospheric, and ranged from −6.6 to 3.1 cm H2O (mean±SD, −1.59±2.09 cm H2O). Measurements of intraperitoneal pressures were repeatable; however, intra‐ and interindividual variance was significantly larger for measurements of gastric pressures. The mean and relative bias for comparison between the 2 techniques was 15.9±5.3 cm H2O and 244.3±199.2%, respectively. The Lin's concordance correlation coefficient between gastric and intraperitoneal pressures was −0.003 but this was not statistically significant (P=0.75).Conclusions
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There was no statistical concordance between measurements of intraabdominal pressure using gastric and intraperitoneal pressure measurement, indicating that gastric pressures cannot be substituted for intraperitoneal pressure measurement. Direct measurement of intraperitoneal pressures may be a more consistent method for comparison of intraabdominal pressures between horses, due to less variability within and between individuals.
Prospective Evaluation of Minimally Invasive Plate Osteosynthesis in 36 Nonarticular Tibial Fractures in Dogs and Cats
Authors: Guiot Laurent P. , Déjardin Loïc M. 
Published: January 2011

Objective:To evaluate the clinical outcome of minimally invasive plate osteosynthesis (MIPO) for nonarticular tibial fractures stabilized using bone plates with or without an intramedullary rod (IMR).Study Design:Prospective study.Animals:Dogs (n=28) and 8 cats.Methods:After closed reduction, fracture fixation was achieved using an epiperiosteal plate inserted percutaneously through epiphyseal small incisions. In some fractures, an IMR was inserted via medial parapatellar arthrotomy. Radiographs were recommended every 3 weeks until clinical union. Postoperative tibial length and alignment were compared with contralateral measurements (P<.05). Time to clinical union and complications were recorded.Results:An IMR was used in 30.5% of the cases. Repaired tibiae were 1% shorter than contralateral tibiae (P<.05). Frontal and sagittal alignment were similar between repaired and contralateral tibiae (P>.05). Six dogs were lost for follow‐up; owners indicated normal function. In 30 cases for which bone healing was documented, mean±SD healing time was 45±20.8 days; however, when considering the 23 cases, which completed preestablished scheduled follow‐ups, healing time was 36±11.6 days. Minor complications occurred in 4 cases (11%). One major complication (3%) consisting of a plate fracture was successfully revised using MIPO with a larger plate.Conclusions:Consistent restoration of alignment was accomplished using MIPO techniques. Furthermore, MIPO appeared to yield faster healing times and lower complication rates than those reported with conventional plate osteosynthesis.
One Stage Functional End‐to‐End Stapled Intestinal Anastomosis and Resection Performed by Nonexpert Surgeons for the Treatment of Small Intestinal Obstruction in 30 Dogs
Authors: Jardel Nicolas , Hidalgo Antoine , Leperlier Dimitri , Manassero Mathieu , Gomes Aymeric , Bedu Anne Sophie , Moissonnier Pierre , Fayolle Pascal , Begon Dominique , Riquois Elisabeth , Viateau Véronique 
Published: January 2011

Objectives:To describe stapled 1‐stage functional end‐to‐end intestinal anastomosis for treatment of small intestinal obstruction in dogs and evaluate outcome when the technique is performed by nonexpert surgeons after limited training in the technique.Study Design:Case series.Animals:Dogs (n=30) with intestinal lesions requiring an enterectomy.Methods:Stapled 1‐stage functional end‐to‐end anastomosis and resection using a GIA‐60 and a TA‐55 stapling devices were performed under supervision of senior residents and faculty surgeons by junior surgeons previously trained in the technique on pigs. Procedure duration and technical problems were recorded. Short‐term results were collected during hospitalization and at suture removal. Long‐term outcome was established by clinical and ultrasonographic examinations at least 2 months after surgery and from written questionnaires, completed by owners.Results:Mean±SD procedure duration was 15±12 minutes. Postoperative recovery was uneventful in 25 dogs. One dog had anastomotic leakage, 1 had a localized abscess at the transverse staple line, and 3 dogs developed an incisional abdominal wall abscess. No long‐term complications occurred (follow‐up, 2–32 months).Conclusion:Stapled 1‐stage functional end‐to‐end anastomosis and resection is a fast and safe procedure in the hand of nonexpert but trained surgeons.
Unilateral Nephrectomy in 10 Cattle
Authors: Vogel Susan R. , Desrochers André , Babkine Marie , Mulon Pierre‐Yves , Nichols Sylvain 
Published: January 2011

Objective:To describe clinical and imaging findings, treatment, and long‐term outcome of cattle undergoing unilateral nephrectomy.Study Design:Case series.Animals:Cattle (n=10).Methods:Medical records (January 1991–August 2008) of cattle that had unilateral nephrectomy were reviewed. Follow‐up data were obtained by owner telephone interview.Results:Nephrectomy was performed without surgical complications. Transient increases in blood urea nitrogen and creatinine concentrations occurred after surgery and then returned to, or below, presurgical values in 9 cattle. Nine cows were discharged and 7 rejoined their respective herd as productive animals without long‐term complications.Conclusions:Ultrasonography was the most useful imaging tool for presurgical diagnosis. Based on our follow‐up data, unilateral nephrectomy resulted in few serious short‐term or long‐term complications, and cattle undergoing this procedure are capable of satisfactory growth, reproduction, and milk production after surgery.
Effect of additive solutions on red blood cell (RBC) membrane properties of stored RBCs prepared from whole blood held for 24 hours at room temperature
Authors: Veale Margaret F. , Healey Gerry , Sparrow Rosemary L. 
Published: January 2011

BACKGROUND: The quality of RBC components is influenced by collection, processing and storage conditions. Regulations require that whole blood (WB) units be refrigerated within 8 hours and processed into RBCs within 24 hours of collection. Overnight room temperature hold of WB has logistical advantages, but the effect on RBC quality has not been fully investigated. RBC additive solutions were compared for their ability to provide improved quality of RBCs prepared from WB held at room temperature for 24 hours.STUDY DESIGN AND METHODS: Leukocyte‐reduced RBCs were prepared from WB held at 20°C on cooling plates for 24 hours prior to processing. RBCs were stored in additive solutions, SAG‐M (control), Erythrosol‐4, and PAGGSM, under standard blood banking conditions and sampled during 49 days of storage. Stored RBCs were evaluated for RBC shape and microparticle (MP) accumulation using flow cytometry. Osmotic fragility, adhesion of RBCs to endothelium under shear stress conditions (0.5 dyne/cm2), and routine RBC quality parameters were assessed.RESULTS: RBCs stored in Erythrosol‐4 and PAGGSM had decreased cell size, reduced osmotic fragility, and decreased accumulation of glycophorin A‐positive MPs and annexin V‐binding MPs compared with RBCs stored in SAG‐M. RBCs stored in erythrosol‐4 had increased adherence to endothelium at days 42 and 49 compared with RBCs stored in SAG‐M or PAGGSM.CONCLUSION: RBCs stored in PAGGSM or Erythrosol‐4 had improved retention of RBC membrane and osmotic resilience. The development of new additive solutions may offer improved quality of RBC components prepared from WB held overnight at room temperature.
Platelet concentrates from fresh or overnight‐stored blood, an international study
Authors: Dijkstra‐Tiekstra M.J. , van der Meer P.F. , Cardigan R. , Devine D. , Prowse C. , Sandgren P. , de Wildt‐Eggen J. ,   for the Biomedical Excellence for Safer Transfusion Collaborative
Published: January 2011

BACKGROUND: Whole blood and also buffy coats (BCs) can be held for a few hours or overnight before processing into blood components or platelet concentrates (PCs). Individual studies have reported a range of outcomes regarding in vitro variables for PCs prepared from fresh and stored whole blood. In this multicenter study, effects of storage of whole blood or BCs on the in vitro quality of PCs were studied.STUDY DESIGN AND METHODS: The leukoreduced BC PCs were prepared from fresh BCs (2‐8 hr after collection; fresh/fresh), from BCs at 20 to 24 hours after collection (fresh/stored), or from BCs prepared from whole blood stored for 20 to 24 hours (stored/fresh). PCs were stored on a flat‐bed shaker at 20 to 24°C for 7 days. PCs were tested on Days 0 (only fresh/fresh), 1, 5, and 7 for in vitro quality. There were six participating centers that tested all three conditions with n = 6 per condition.RESULTS: In comparison to fresh/stored and stored/fresh PCs, fresh/fresh PCs exhibited a lower platelet (PLT) count (Day 1—220 × 109 ± 70 × 109 vs. 324 × 109 ± 50 × 109 and 368 × 109 ± 56 × 109 PLTs/PC), lactate, pCO2, and hypotonic shock response (HSR; Days 5 and 7; Day 7—50 ± 13% vs. 57 ± 12 and 63 ± 11%) and a higher pH, glucose, pO2, and CD62P expression (than stored/fresh PCs only; Day 7—33 ± 10% vs. 28 ± 12 and 24 ± 11%; p < 0.05). No differences were observed for volume, swirling effect, white blood cell count, annexin V binding, or aggregation between these conditions.CONCLUSION: Based on PLT count, HSR, and PLT activation, PCs are best prepared after 20 to 24 hours hold of the whole blood or BCs.
Anterior Temporal Artery Sign in CT Angiography Predicts Reduced Fatal Brain Edema and Mortality in Acute M1 Middle Cerebral Artery Occlusions
Authors: Menon Bijoy K. , Bal Simerpreet , Modi Jayesh , Sohn Sung Il , Watson Timothy W.J. , Hill Michael D. , Demchuk Andrew M. , Goyal Mayank 
Published: January 2011

ABSTRACTBACKGROUNDMortality in acute ischemic middle cerebral artery (MCA) stroke ranges from 5% to 45%. We identify a vascular imaging sign, presence of “prominent anterior temporal artery” on computed tomography (CT) angiography (CTA) and investigate whether it predicts mortality in acute M1‐MCA occlusions.METHODSOne hundred and two patients with acute M1‐MCA occlusions from 2003–to 2007 were included in the study. A prominent anterior temporal artery arising from proximal M1 MCA was identified by two readers blinded to clinical outcome. Primary clinical outcome was survival (modified Rankin Scale [mRS] 0‐5) at 3 months.RESULTSAn anterior temporal artery arising from M1 MCA was present in 20/102 (20%). Eighteen of 20 (90%) patients with this sign survived at 3 months (mRS 0‐5) when compared to 66/82 (80.4%) patients without the sign (odds ratio 2.2 CI95 .5‐10.4). The sign has a sensitivity of 21% (CI95 .13‐.25) but specificity of 89% (CI95 .64‐.98) in predicting survival at 3 months. Positive predictive value was 90% with likelihood ratio of 1.9 (CI95 .9‐7.6).CONCLUSIONPresence of prominent anterior temporal artery in M1‐MCA occlusions on CTA identifies a group of patients with reduced case fatality. The mechanism is likely related to a reduced chance of malignant cerebral edema. J Neuroimaging 2012;22:145‐148.
Endovascular Therapy of a Craniocervical Pial AVF Fed by the Anterior Spinal Artery
Authors: Alshekhlee Amer , Edgell Randall C. , Kale Sushant P. , Kitchener Jacob , Vora Nirav 
Published: January 2011

ABSTRACTThough pial arteriovenous fistulae (PAVF) are an uncommon cerebrovascular disorder, their presentation with subarachnoid hemorrhage (SAH) is not rare. PAVF near the craniocervical junction are rare and may have a worse outcome. These fistulae are often fed from either the carotid and/or the vertebrobasilar systems, but are rarely fed by the anterior spinal artery. We report the case of a young man presenting with SAH. Cerebral angiography revealed 2 AVF, a symptomatic PAVF located at the craniocervical junction and fed from the anterior spinal artery and incidental dural AVF (DAVF) originate from the left occipital and middle meningeal arteries. These fistulae were treated with different endovascular techniques, including Onyx and platinum coil embolization into the feeding arteries of the DAVF and PAVF, respectively.
An Initial Study of Three‐Dimensional Perfused Blood Volume Computed Tomography Imaging of Patients with Anterior Circulation Hyperacute Cerebral Infarction
Authors: Zhu Hai‐Yun , Geng Dao‐Ying , Geng Chang‐Ming , Wei Dao‐Ming 
Published: January 2011

ABSTRACTAIMTo evaluate the value of three‐dimensional (3D) whole brain perfused volume computed tomography (3D PBV CT) based on CT angiography (CTA) data in patients with hyperacute cerebral infarction.METHODSThirty‐five patients who had suffered stroke with anterior circulation within 3 hours underwent nonenhanced CT (NECT) scanning and CTA. Neuro PBV, a 3D software, was utilized to process the raw CTA data and a PBV image of the brain was obtained. Magnetic resonance imaging (MRI) was performed 6 hours after CT imaging. The volume and quantity of the ischemic lesion on 3D PBV and NECT were compared with MR‐diffuse‐weighted imaging (DWI).RESULTSThe numbers of cerebral infarcts detected by MRI, PBV, and NECT were 40, 38 and 16, respectively. The results of kappa analysis between NECT and PBV with MR were −.0128 and .7622, and a paired t‐test analysis for the measurement of infarct volume between PBV and MRI was t = 7.249, P > .05. The lesions that were not detected by PBV volumes less than 4.5 cm3.CONCLUSION3D PBV CT has the potential to assess the full extent of an ischemic stroke at an early stage, whereas PBV is limited to the detection of small infarcts. The 3D PBV CT technique based on CTA data requires no additional radiation exposure or contrast medium injection, and can be performed in a short period of time. J Neuroimaging 2012;22:149‐154.
The Effect of Clomiphene Citrate and Tamoxifen on the Cervical Mucus
Authors: Tepper Ron , Lunenfeld Bruno , Shalev Joseph , Ovadia Jardena , Blankstein Josef 
Published: January 2011

AbstractThe anti‐estrogenic effect of clomiphene citrate (CC) and tamoxifen (TMX) on cervical mucus was evaluated in a prospective crossover study. Ten women underwent randomized alternate cyclical treatment with either 100 mg CC, 40 mg TMX daily, or with placebo. The effect of CC, TMX and placebo on serum estradiol (E2), cervical mucus secretion and on the development of ovarian follicles was evaluated. Compared with placebo, treatment with CC and TMX significantly increased the number of mature ovarian follicles on the day of assumed ovulation (p <0.05), elevated E, secretion (p <0.05) and decreased cervical score (p <0.05). It can be concluded that anti‐estrogenic agents reduced the secretion of cervical mucus. However, in most cases, the excessive E, production due to multiple follicular growth overcomes the anti‐estrogenic effect.
Perineal Rupture Following Vaginal Delivery Long‐term Consequences
Authors: Sørensen Sten Mellerup , Bondesen Helle , Istre Olav , Vilmann Peter 
Published: January 2011

AbstractTwenty‐five women with complete perineal rupture were compared with a control group of 25 women, with regard to risk factors and possible long‐term sequelae as a consequence of perineal damage. Following an average period of 78 months (52—‐1231, all women received a questionnaire and were invited to a clinical follow‐up, which included perineal inspection and measurement of the anal pressure profile. Vacuum extraction was more frequent in the rupture group than among controls (p < 0.002). Eighty percent of the women in the rupture group were primiparae, compared with an overall rate of 40% (p < 0.02). Forty‐two percent of the women in the rupture group reported anal incontinence, compared with none in the control group (p <0.01). Most of these women reported stress‐provoked incontinence regarding flatus and loose stools. Measurement of the anal pressure profile showed markedly reduced sphincter pressure, with maximum squeeze in the rupture group, but no differences were found regarding maximum anal pressure at rest. Sphincter length was reduced both at rest and with maximal squeeze in the rupture group. It is concluded that complete perineal rupture is a condition with possible long‐term consequences such as reduced sphincter strength and partial anal incontinence.
Contraceptive use in a Sample of Young Danish Females
Authors: Wielandt Hanne , Wermuth Lene , Pedersen Marianne Riber 
Published: January 2011

AbstractDuring the period April 1984‐February 1985, 4 test samples of totally 380 young Danish women aged 16–20 years old were invited to interview about contraception and sexual behaviour. The response rate was 75,3%.There were 208 (74,0%) who had had sexual debut. Median age was estimated to 16.8 years. At first intercourse 168 (80.8%) used contraception, 36.5% used condom and 36.1% oral contraception (OC). Among teenage‐girls with sexual debut before 15 years old 32.5% were unprotected against pregnancy.At the time of the interview 64.4% did use contraception. The most frequently used contraceptive device was OC (46.6%). Teenage‐girls changed the contraceptive method from condom to OC after sexual debut. A small proportion of sexually active girls (8%) did not use contraception neither at first intercourse nor at the moment.
Intrapartum Management of Insulin‐Dependent Diabetes Mellitus (IDDM) Gestants
Authors: Feldberg Dov , Dicker Dov , Samuel Nurith , Peleg Dan , Karp Moshe , Goldman Jack A. 
Published: January 2011

AbstractTwo groups of insulin‐dependent diabetes mellitus (IDDM) parturients were managed according to different intrapartum protocols and compared with a control group of normal women in labor. Thirty‐seven patients received conventional intensified insulin therapy during pregnancy and intravenous continuous insulin infusion during labor. Twenty‐eight women were managed by continuous subcutaneous insulin infusion pump (CSIIP) throughout gestation and this therapeutic approach was continued during labor. When the two glucose control techniques were compared, CSIIP was superior to achieving and maintaining intrapartum optimal metabolic control, reducing significantly the incidence of acute fetal distress, thus lowering the cesarean section rate and neonatal hypoglycemia. Consequently we concur with the recommendation that firm prepartum as well as intrapartum diabetic control is mandatory for successful management of labor in IDDM patients.
Benefits of Continuous Infusion Epidural Analgesia Throughout Vaginal Delivery
Authors: Johnsrud Marja‐Liisa , Dale Per Olav , Løvland Bjørn 
Published: January 2011

AbstractTwo groups of nulliparous women with fetuses in singleton vertex presentation received continuous infusion epidural analgesia (EDA) with bupivacaine: group A (90 parturients) without infusion analgesia in the second stage of labor and group B (90 parturients) with infusion analgesia throughout delivery. The groups were compared regarding pain relief, duration of the second stage, persistent malrotation of the fetal head, and rate of instrumental vaginal delivery. The continuous infusion EDA gave satisfactory pain relief in 93.3% of the parturients in group A and 97.8% in group B. The duration of second stage was the same in both groups. There were more persistent mal‐rotations of the fetal head in group A, but the malrotation did not affect the mode of deli: very. The rate of instrumental vaginal delivery was 25.5% in both groups. The main cause of operative intervention was delay in the second stage. When the continuous infusion technique is used, it seems unreasonable to discontinue the EDA and thereby deprive the parturient of analgesia during the second stage.
Is Cesarean Section Justified for Delivery of the Second Twin?
Authors: Pschera Helmut , Jonasson Aino 
Published: January 2011

AbstractDuring the last 7‐year period, the second twin was delivered by cesarean section in three of 161 twin pregnancies in our Department. The main reasons for this procedure were fetal distress caused by malpresentation or cord prolapse in 2 cases and in the third case placental separation. Cesarean section for delivery of the second twin is justified only in selected cases.