bluuebunny/crossref_metadata_2025_split huggingface dataset:
The impact of CMV prevention on long‐term recipient and graft survival in heart transplant recipients: analysis of the Scientific Registry of Transplant Recipients (SRTR) database
Authors: Snydman David R. , Kistler Kristin D. , Ulsh Paula , Bergman Garrett E. , Vensak Judith , Morris Jonathan 
Published: April 2011

Snydman DR, Kistler KD, Ulsh P, Bergman GE, Vensak J, Morris J. The impact of CMV prevention on long‐term recipient and graft survival in heart transplant recipients: analysis of the Scientific Registry of Transplant Recipients (SRTR) database. Clin Transplant 2011: 25: E455–E462. © 2011 John Wiley & Sons A/S.Abstract:  The association between cytomegalovirus immunoglobulin (CMVIG) and long‐term clinical outcomes in heart transplantation has not been evaluated using data from large national databases. We examined the association between CMVIG, with and without antivirals, or antivirals alone, and long‐term recipient and graft survival in heart transplantation using data from the Scientific Registry of Transplant Recipients. Recipients transplanted between January 1995 and October 2008, ≤80 yr old, of primary, single‐organ heart transplants, recorded as receiving CMVIG with or without antivirals (n = 2112), antivirals without CMVIG (n = 12 089), or no prophylaxis (n = 14 661), at hospital discharge, were included. Kaplan–Meier analysis was used to examine death and graft loss at seven yr post‐transplantation; Cox proportional hazards regression was used to estimate the adjusted risk of graft loss and death for prophylaxis vs. no prophylaxis. CMVIG use (± other antivirals) was associated with increased recipient (69% vs. 64%, p < 0.001) and graft (67% vs. 63%, p < 0.001) survival. Antivirals alone also demonstrated increased recipient (68% vs. 64%, p < 0.001) and graft survival (66% vs. 63%, p < 0.001). Cox models demonstrated that CMVIG (± other antivirals) was independently associated with decreased risk for death (hazard ratio, HR 0.79, p < 0.001) and graft loss (HR 0.78, p < 0.001) as were antivirals alone (mortality HR: 0.79, p < 0.001; graft loss: HR 0.78, p < 0.001).
Cholestasis as the leading sign of a transmesenteric hernia in a split‐liver transplanted child – A case report and review of literature
Authors: Eberhardt Christiane S. , Merlini Laura , McLin Valérie A. , Wildhaber Barbara E. 
Published: April 2011

Eberhardt CS, Merlini L, McLin VA, Wildhaber BE. Cholestasis as the leading sign of a transmesenteric hernia in a split‐liver transplanted child – A case report and review of literature.Abstract:  Internal hernias are an extremely rare complication after pediatric liver transplantation, and its presentation with cholestasis has not been described to date. We report the case of a 12‐yr‐old boy who presented with moderate abdominal pain 11 yr after split liver transplantation and biliary‐enteric anastomosis. He developed severe jaundice within 24 h of initial presentation. Imaging studies revealed ascites, dilation of the intrahepatic bile ducts, a dilated Roux‐en‐Y‐loop, with the loop truncated at the level of the mesenteric artery, which performed a narrow right‐to‐left loop. At laparotomy, a transmesenteric internal hernia at the root of the jejunal mesentery was identified, originating from the creation of the Y‐loop; the Roux‐en‐Y‐loop and its adjacent intestinal loops had slipped through the opening. The Roux‐en‐Y loop was ischemic from strangulation, and the rest of the intestine well perfused. No surgical resection was necessary following reduction. The patient recovered completely. We discuss diagnosis and management of internal hernias, and review radiological signs. Internal transmesenteric hernias can occur at any time after liver transplantation and prompt diagnosis and surgical treatment are vital.
Chronic norovirus infection in pediatric hematopoietic stem cell transplant recipients: A cause of prolonged intestinal failure requiring intensive nutritional support
Authors: Saif M. A. , Bonney D. K. , Bigger B. , Forsythe L. , Williams N. , Page J. , Babiker Z. O. , Guiver M. , Turner A. J. , Hughes S. , Wynn R. F. 
Published: April 2011

Saif MA, Bonney DK, Bigger B, Forsythe L, Williams N, Page J, Babiker ZO, Guiver M, Turner AJ, Hughes S, Wynn RF. Chronic norovirus infection in pediatric hematopoietic stem cell transplant recipients: A cause of prolonged intestinal failure requiring intensive nutritional support.  Pediatr Transplantation 2011: 15: 505–509. © 2011 John Wiley & Sons A/S.Abstract:  Norovirus infection is a major cause of nonbacterial gastroenteritis. In immunocompetent individuals the illness caused by norovirus is mostly self limiting. Excretion of norovirus has been reported to be prolonged in the immunocompromised including adult HSCT recipients. We report a case series of 13 children who received HSCT and required prolonged parenteral and enteral nutrition due to severe gut dysfunction accompanying protracted norovirus excretion that was monitored by RT‐PCR. The median duration of viral excretion was 150 days (range 60‐380) and the eventual clearance of norovirus from feces was closely associated with donor T cell recovery in the peripheral blood. There was no disease manifestation beyond the gut but the severity and length of norovirus associated illness suggests that HSCT should be delayed where possible in patients excreting the virus prior to conditioning therapy.
Incidental hepatic schistosomiasis in a liver transplant recipient
Authors: Ariza‐Heredia E. , Razonable R.R. 
Published: April 2011

E. Ariza‐Heredia & R.R. Razonable. Incidental hepatic schistosomiasis in a liver transplant recipient. Transpl Infect Dis 2011. All rights reserved
Abstract: Hepatic schistosomiasis is a well recognized cause of chronic liver disease and portal hypertension. Herein, we describe a case of a 62‐year‐old Kuwaiti man who underwent liver transplantation for non‐alcoholic steatohepatitis and, as an incidental finding in the histopathology of the explanted liver, eggs consistent with Schistosoma were found. In endemic regions, hepatic schistosomiasis is often observed as an incidental finding in explanted livers of patients who receive liver transplantation for other indications. In the context of this case, we provide a brief review of the management of schistosomiasis in transplant recipients.
Two children with differing outcomes after treatment for pulmonary tuberculosis diagnosed after allogeneic hematopoietic stem cell transplantation
Authors: Lee J.W. , Kwon H.‐J. , Jang P.‐S. , Chung N.‐G. , Cho B. , Jeong D.‐C. , Kang J.‐H. , Kim H.‐K. 
Published: April 2011

J.W. Lee, H.‐J. Kwon, P.‐S. Jang, N.‐G. Chung, B. Cho, D.‐C. Jeong, J.‐H. Kang, H.‐K. Kim. Two children with differing outcomes after treatment for pulmonary tuberculosis diagnosed after allogeneic hematopoietic stem cell transplantation. Transpl Infect Dis 2011: 13: 520–523. All rights reserved.Abstract: Tuberculosis (TB) is a rare infectious complication after hematopoietic stem cell transplantation (HSCT), but may be more significant in areas where the disease is endemic. Here, we present the clinical course of 2 children with acute lymphoblastic leukemia who were diagnosed with pulmonary  TB after allogeneic HSCT. Both patients were treated for either probable or possible invasive fungal infection, as well as  TB. One patient, diagnosed with TB 3 months after HSCT, showed remittent fever and symptoms that progressed to acute respiratory distress syndrome and death, despite 3 modifications to the anti‐TB regimen. In contrast, another patient who was diagnosed with TB 8 months after transplantation, responded well to anti‐TB medication and completed 1 year of treatment with resolution of lung lesions. Co‐morbid opportunistic infections, profound host immunosuppression early after transplantation, and potential risk of multi‐drug resistant‐TB may act as major barriers to effective treatment of TB after HSCT despite appropriate anti‐TB medication.
Spatial variation in the temporal change of male and female melanic ornamentation in the barn owl
Authors: ROULIN A. , ANTONIAZZA S. , BURRI R. 
Published: April 2011

AbstractBecause the magnitude of selection can vary between sexes and in space and time, sexually antagonistic selection is difficult to demonstrate. In a Swiss population of barn owls (Tyto alba), a heritable eumelanic colour trait (size of black spots on ventral feathers) was positively selected with respect to yearling survival only in females. It remains unclear whether the absence of negative selection in males is typical in this species. To tackle this issue indirectly, we measured the size of black spots in 1733 skin specimens collected by museums from 1816 to 2001 in seven European countries and in the Middle‐East. The temporal change in spot size was sex‐ and country‐specific. In males, spots became smaller particularly in three countries (Middle‐East, Italy and Switzerland). In females, the size of spots increased significantly in two countries (UK and Spain) and decreased in two others (Germany and Switzerland). Because migration and phenotypic plasticity cannot explain these results, selection is the most likely cause. The weaker temporal change in spot size in females than males may be because of the combined effect of strong genetic correlation between the sexes and stronger negative selection in males than positive selection in females. We thus suggest that in the barn owl, spot size (or genetically correlated traits) is sexually antagonistically selected and that its pattern of selection may account for the maintenance of its variation and sexual dimorphism.
Coxiella burnetii Seropositivity Is Highly Stable Throughout Gestation in Lactating High‐Producing Dairy Cows
Authors: Garcia‐Ispierto I , Almería S , López‐Gatius F 
Published: April 2011

ContentsThe aims of this study were to analyse, in high‐producing dairy cows, plasma Coxiella burnetii antibody titres and seroconversion throughout gestation, along with possible factors affecting such titres. The study was performed on 65 lactating pregnant non‐aborting animals in a commercial Holstein‐Friesian dairy herd in northeastern Spain. Blood samples for antibody determinations were collected on days 40, 90, 120, 150, 180 and 210 of gestation. By General Linear Model (GLM) repeated measures analysis of variance, the effects of milk production and reproductive variables as well as Neospora caninum‐seropositivity on C. burnetii antibody levels for all animals and for seropositive animals were established. Significant effects were observed of day of gestation, parity and N. caninum‐seropositivity (between subject effects) on the C. burnetii antibody levels recorded for the whole population of animals throughout the gestation period. C. burnetii antibody levels were higher in primiparous than in multiparous cows, with titres in primiparous cows diminishing during the post‐partum period. In seropositive cows, significant effects were observed of milk production and inseminating bull on gestational C. burnetii antibody levels. When the data were subjected to binary logistic regression considering C. burnetii‐seropositivity as the dependent variable, the resultant odds ratios indicated that the likelihood of C. burnetii‐seropositivity was lower in N. caninum‐seropositive animals (OR 0.12) compared to N. caninum‐seronegative animals, and in multiparous cows (OR 0.12) compared to primiparous cows. In conclusion, Coxiella‐infected dams remained seropositive during the whole gestation period, though primiparous cows showed a drop in antibody titres post‐partum. No seronegative cow suffered seroconversion. Presence of both, N. caninum and C. burnetii antibodies in the same animal, was associated with a decrease in antibody titres against C. burnetii, perhaps indicating some cross‐protection in animals infected by both pathogens.
PHARMACOKINETICS OF SEVERAL SUBCUTANEOUS DOSES OF ERYTHROPOIETIN: POTENTIAL IMPLICATIONS FOR BLOOD TRANSFUSION
Authors: Sans T. , Joven J. , Vilella E. , Masdeu G. , Farrè M. 
Published: April 2011

The aim of the present study was to assess the effectiveness of repeated subcutaneous low‐dose recombinant human erythropoietin (rHuEPO) on parameters associated with improved procurement of autologous blood; a procedure regularly used to preclude the need for homologous blood transfusion at the time of elective surgery.
Three groups of three volunteers each (n= 9) were administered one of three low doses of rHuEPO (30, 60 or 100 IU/kg body weight, s.c.) on days 1,4 and 8. The plasma pharmacokinetic profile of rHuEPO was studied after the first and third injections. Statistical evaluations were intragroup and intra‐individual comparisons.
There was a linear relationship between maximum plasma concentration (Cmax) and dose. In the overall study group, Cmax and area under the curve (AUC) were significantly decreased, while the mean residence time (MRT) and elimination half‐life (t1/2β) were significantly increased on day 8 relative to day 1. Significant and sustained increases in reticulocytes were observed after rHuEPO administration, which were maintained above the predose values throughout the study period.
In conclusion, rHuEPO, by subcutaneous repeat‐dose, was eliminated more slowly and remained longer in the circulation, despite lowered plasma concentrations. Repeated low rHuEPO administration at doses ≥ 60 IU/kg bodyweight stimulated modest but sustained reticulocyte concentrations, suggesting that cost may be substantially decreased in autologous blood donation or perioperative treatment programmes.
Comparison of the clinical features of rapid eye movement sleep behavior disorder in patients with Parkinson's disease and multiple system atrophy
Authors: Nomura Takashi , Inoue Yuichi , Högl Birgit , Uemura Yusuke , Yasui Kenichi , Sasai Taeko , Namba Kazuyoshi , Nakashima Kenji 
Published: April 2011

Aims:  The aim of this study was to evaluate differences in the clinical presentation and polysomnographic characteristics of rapid eye movement sleep behavior disorder (RBD) between patients with Parkinson's disease (PD) and those with multiple system atrophy (MSA).Methods:  We conducted clinical interviews examining RBD symptoms, including violent and non‐violent behaviors, in 49 patients with PD and 16 patients with MSA (as well as their bed partners) and performed polysomnography on all subject patients.Results:  Twenty‐seven patients with PD (55.1%) and 11 patients with MSA (68.8%) had rapid eye movement sleep without atonia (RWA) on polysomnogram. The relative amounts of RWA were quite similar between the two groups. For most of the RWA‐positive patients in both groups, RBD symptoms remained non‐violent or silent. RBD symptoms in PD patients seemed to increase with the course of PD, while most of the RBD symptoms in the MSA patients occurred just prior to or at the onset of MSA and then disappeared within a short period.Conclusion:  Although PD and MSA frequently accompany RWA, RBD symptoms often remain non‐violent or silent. Differences in the course of RBD symptoms in patients with PD and MSA may reflect the difference in the degeneration process of the two disorders.
Suicide in a large population of former psychiatric inpatients
Authors: Sani Gabriele , Tondo Leonardo , Koukopoulos Athanasios , Reginaldi Daniela , Kotzalidis Giorgio D. , Koukopoulos Alexia E. , Manfredi Giovanni , Mazzarini Lorenzo , Pacchiarotti Isabella , Simonetti Alessio , Ambrosi Elisa , Angeletti Gloria , Girardi Paolo , Tatarelli Roberto 
Published: April 2011

Aims:  The aim of this study was to identify predictors of completed suicide in a wide sample of psychiatric inpatients receiving retrospective and prospective DSM‐IV diagnoses.Methods:  We followed up 4441 severe psychiatric patients who were hospitalized for some time during a 35‐year period in a private hospital setting. We collected sociodemographic, clinical and temperamental data.Results:  Ninety‐six patients from the sample committed suicide. There were no sex differences in suicide completion and no differences between major psychiatric disorders, but people who had been hospitalized for anxiety disorders did not commit suicide and people with bipolar disorders were more likely to commit suicide than people with unipolar major depression. Shorter‐term treatment with lithium and anticonvulsants, longer‐term treatment with antidepressants, history of suicide attempts, suicidal thinking, and single status positively predicted completed suicide. Suicide tended to occur after a mean period of about 14 years of duration of disease. Patients' symptoms during the period preceding suicide were assessed through interviewing patients' physicians or family members. Symptoms occurring in >10% of cases were, in decreasing order, inner tension, racing/crowded thoughts, aggressive behavior, guilt, psychomotor agitation, persecutory ideation, anxiety, and hallucinations. Surprisingly, cyclothymic temperament was less associated with completed suicide as compared to other temperaments.Conclusions:  Suicide is likely to occur in a milieu of agitation, mixed anxiety and depression, and psychosis. Longer‐term mood stabilizer treatment may reduce the rate of completed suicide.
Genetic variation relevant for the conservation of the narrow endemic Senecio carbonensis (Asteraceae) from the southern Andes
Authors: FERNÁNDEZ MARTINA , EZCURRA CECILIA , QUIROGA MARIA PAULA , PREMOLI ANDREA C. 
Published: April 2011

AbstractWe studied morphological variation, reproductive biology and genetic structure of Senecio carbonensis, a narrow endemic from high elevations of the southern Andes, and compared it to Senecio peteroanus, a closely related widespread congeneric species. Using ANOVAs and discriminant analysis we showed that populations of S. carbonensis were more similar to each other in their morphology, had comparatively limited reproductive capacity and presented lower plant density and more reduced plant cover than populations of S. peteroanus. Similar high genetic variation was found at the population and species level in both species, based on isozyme variation at 14 and 11 putative gene loci that were resolved in S. carbonensis and S. peteroanus, respectively. The two species were genetically distinct. However, the small genetic distance between populations of each species suggests that either they were recently founded and that genetic drift did not have time to promote divergence, or that its effects are masked by significant current gene flow. These results show that ecological and reproductive characteristics of S. carbonensis may limit its extension and abundance. In contrast, high genetic variation at the population level is probably favored by self‐incompatibility. Despite the restricted geographical distribution and low plant density of S. carbonensis populations, genetic characteristics do not seem to be limiting their long‐term persistence. This information suggests that populations of S. carbonensis are not at risk of extinction as a result of genetic factors, although it is important to study and monitor population dynamics to further assess the degree of recruitment through time.
Vitamin D deficiency among healthy infants and toddlers: A prospective study from Irbid, Jordan
Authors: Abdul‐Razzak Khalid K. , Ajlony Mohammed‐Jafar A. , Khoursheed Abeer M. , Obeidat Bayan A. 
Published: April 2011

AbstractBackground:  The aim of this study was to estimate the prevalence of vitamin D deficiency among healthy infants and toddlers, as well as its associated factors, in Irbid, Jordan.Methods:  A total of 275 subjects (136 infants and 139 toddlers) aged 6–36 months participated in this study. Information concerning sociodemographic characterastics and early feeding patterns was collected using a self‐guided questionnaire. Plasma vitamin D, calcium, phosphorous, and alkaline phosphatase activity were measured.Results:  The prevalence of vitamin D deficiency was 28% (16.7% for severe vitamin D deficiency and 11.3% for vitamin D deficiency) and vitamin D insufficiency was 28.4%. Plasma calcium and alkaline phosphatase levels showed no correlation with the vitamin D status of the study population. For both age groups, a significant association was found between vitamin D status and sun exposure (P < 0.001). A significant association between infant feeding practices and vitamin D status was found (P < 0.001). Infants who were exclusively breast‐fed had higher risk for vitamin D deficiency and vitamin D insufficiency than those who were bottle‐fed. Multivariate logistic regression analyses results showed that female sex, low sun exposure and exclusive breast‐feeding were the main determents of vitamin D levels.Conclusion:  The prevalence of vitamin D deficiency is considered to be high among northern Jordanian infants and toddlers. Sun exposure of less than 30 min daily and exclusively breast‐feeding are the main factors for developing vitamin D deficiency.
Blood transfusion: old blood, new blood or no blood
Authors: Duggan J. M. 
Published: April 2011

AbstractVigorous blood transfusion has long been regarded as having an essential role in the management of acute gastrointestinal haemorrhage. Two new studies, one a nationwide audit of acute gastrointestinal haemorrhage in the UK and another, a complex physiological study of stored blood from the USA, offer new insights.
Medically refractory neurosarcoidosis treated with infliximab
Authors: Pereira J. , Anderson N. E. , McAuley D. , Bergin P. , Kilfoyle D. , Fink J. 
Published: April 2011

AbstractNeurosarcoidosis can worsen despite standard immunosuppressive therapy, a situation for which there is no established medical management. We present three cases of medically refractory neurosarcoidosis treated with infliximab. All three patients showed a clinical response to this treatment and side effects were limited. A summary of reported cases of neurosarcoidosis treated with infliximab is included. This case series supports a role for infliximab in the treatment of patients with medically refractory neurosarcoidosis.
Assessing and conceptualizing orgasm after a spinal cord injury
Authors: Courtois Frédérique , Charvier Kathleen , Vézina Jean‐Guy , Morel Journel Nicolas , Carrier Serge , Jacquemin Géraldine , Côté Isabelle 
Published: April 2011

Study Type – Aetiology (individual cohort)Level of Evidence 2bWhat’s known on the subject? and What does the study add? This study provides the first questionnaire on the specific bodily sensations that can be perceived at orgasm thereby complementing the subjective phenomenological experience of orgasm.OBJECTIVES
To provide a questionnaire for assessing the sensations characterizing orgasm.
To test the hypothesis that orgasm is related to autonomic hyperreflexia (AHR) in individuals with a spinal cord injury (SCI).
SUBJECTS AND METHODS
A total of 97 men with SCI, of whom 50 showed AHR at ejaculation and 39 showed no AHR, were compared.
Ejaculation was obtained through natural stimulation, vibrostimulation or vibrostimulation combined with midodrine (5–25 mg).
Cardiovascular measures were recorded before, at, and after each test.
Responses to the questionnaire were divided into four categories: cardiovascular, muscular, autonomic and dysreflexic sensations.
RESULTS
Significantly more sensations were described at ejaculation than with sexual stimulation alone.
Men with SCI who experienced AHR at ejaculation reported significantly more cardiovascular, muscular, autonomic and dysreflexic responses than those who did not.
There was no difference between men with complete and those with incomplete lesions.
CONCLUSIONS
The findings show that the questionnaire is a useful tool to assess orgasm and to guide patients in identifying the bodily sensations that accompany or build up to orgasm.
The findings also support the hypothesis that orgasm may be related to the presence of AHR in individuals with SCI. Data from able‐bodied men also suggest that AHR could be related to orgasm, as increases in blood pressure are observed at ejaculation along with cardiovascular, autonomic and muscular sensations.