bluuebunny/crossref_metadata_2025_split huggingface dataset:
Health‐related quality of life among thyroid cancer survivors: a systematic review
Authors: Husson Olga , Haak Harm R. , Oranje Wilma A. , Mols Floortje , Reemst Peter H. M. , van de Poll‐Franse Lonneke V. 
Published: May 2011

SummaryBackground  Treatment and follow‐up care procedures of thyroid cancer impose great challenges on survivors and could potentially affect their health‐related quality of life (HRQoL).Methods  Two authors systematically reviewed the available literature on HRQoL of thyroid cancer survivors. A PubMed literature search for original articles published until February 2011 was performed. Twenty‐seven articles, published between 1997 and 2010, which met the predefined inclusion criteria, were subjected to a quality checklist.Results  All selected studies, except one, were of adequate or good quality. Surgery had a negative impact on short‐term HRQoL scores, but these scores returned to preoperational levels when time since surgery increased. Long‐term thyroid hormone therapy (levothyroxine) can lead to abnormalities like hyperthyroidism. HRQoL was most affected during thyroid hormone withdrawal for radioiodine remnant ablation or follow‐up procedures. The use of recombinant human thyroid stimulating hormone instead of hormone withdrawal leads to considerable improvements in HRQoL during follow‐up testing. The results for (long‐term) survivors were contradicting. While most (long‐term) survivors report some specific long‐lasting health problems, some studies found a lower HRQoL for thyroid cancer survivors compared with a healthy population or other reference groups, whereas other studies found similar HRQoL levels.Conclusion  This review indicates that thyroid cancer survivors generally have a similar or slightly worse HRQoL compared with the normative population; however, they report some specific medical problems after cancer treatment and follow‐up tests, which have a direct negative impact on their current HRQoL and could affect their long‐term HRQoL. Specific longitudinal survivorship studies are lacking.
Activated protein C protects vascular endothelial cells from apoptosis in malaria and in sepsis
Authors: Hemmer Christoph J. , Löbermann Micha , Unverricht Marcus , Vogt A. , Krause Robert , Reisinger Emil C. 
Published: May 2011

SummaryObjective  In malaria and sepsis, apoptotic endothelial damage is preventable in vitro by antioxidants and protease inhibitors. Activated protein C, which has anti‐apoptotic effects, improves survival in sepsis. Therefore, we studied whether activated protein C prevents endothelial cell apoptosis, induced by serum from patients with malaria or sepsis.Methods  Endothelial cells were incubated with patient sera (Plasmodium falciparum malaria, Escherichia coli sepsis, Staphylococcus aureus sepsis) or culture supernatants of the respective organisms, with or without neutrophils. Activated protein C was used to reduce endothelial cell apoptosis in vitro. The proportion of apoptotic endothelial cells was determined by TUNEL staining.Results  The apoptosis‐inducing effect of patient sera or culture supernatants (P. falciparum, E. coli, S. aureus) on endothelial cells was augmented by neutrophils and reduced by activated protein C in the presence of neutrophils. Pre‐incubating either endothelial cells or neutrophils with activated protein C also reduced the endothelial cell apoptosis rate. The pro‐apoptotic effect of P. falciparum supernatant was reduced by pan‐caspase inhibitor and caspase 8 inhibitor, but not by caspase 9 inhibitor. The pro‐apoptotic effect of E. coli and S. aureus supernatants was also reduced by caspase 9 inhibitor.Conclusions  Activated protein C protects vascular endothelial cells from apoptosis triggered by patient sera or culture supernatants in combination with neutrophils. It seems to act both on neutrophils and on endothelial cells. Activated protein C blocks caspase‐8‐dependent apoptosis, which accounts for endothelial damage in sepsis and malaria. Therefore, activated protein C might offer clinical benefit not only in sepsis but also in malaria.
Increase in de novo allergies after paediatric liver transplantation: The Brisbane experience
Authors: Noble C. , Peake J. , Lewindon P. J. 
Published: May 2011

Noble C, Peake J, Lewindon PJ. Increase in de novo allergies after paediatric liver transplantation: The Brisbane experience.  Pediatr Transplantation 2011: 15: 451–454. © 2011 John Wiley & Sons A/S.Abstract:  Pediatric liver transplantation is a successful procedure with 10‐yr survival rate of 70%; following transplantation, the emphasis on promoting good quality of life is important. The increasing prevalence of allergic disorders in the general population and an increase in food allergy following solid organ transplantation are described in patients, especially in children, but the contribution to morbidity post‐OLT has not been addressed. Objectives: Identifying the incidence de novo allergies post‐OLT performed by QLTS over 11 yr. Methods: Comprehensive medical record review of OLT recipients during study period. Results: From 1st July 1998 to 1st August 2009, 78 children received 85 cadaveric OLT; 60 children survived. Allergic disease was documented in 24/60 (40%) survivors. De novo food allergies were diagnosed in 12/60 (20%) (Table 2), 9/12 occurred in children who were infants at time of transplant. Ten of 12 had severe allergies, six anaphylactic; 6/60 (10%) carry an EpiPen. Only 31/60 (51%) diagnosed are followed in Queensland, suggesting severe allergic disease in our cohort is an underestimate. Conclusion: Serious allergic disease post‐OLT is clinically important, especially in infants at time of transplant, and should be targeted for specialist allergist referral and risk management.

Allergic diseases reported in pre‐ and post‐OLT

Atopy
Pre‐transplant number N = 78
Post‐transplant number N = 78

Asthma
4
5

Eczema
3
6

Allergic rhinitis
1
1

Food allergy
2
14

Eosinophilic oesophagitis
1
4

Other (drug)
6
19

Total
17 reactions 10 patients
49 reactions 24 patients
Recurrent intrahepatic pigmented stones after liver transplantation in a patient with hemoglobin SC disease: Case report and review of the literature
Authors: Tomaino Juli , Keegan Tara , Kerkar Nanda , Facciuto Marcelo , Miloh Tamir , Taouli Bachir , Hurlet Anne , Weintraub Joshua , Sejpal Divyesh , Arnon Ronen 
Published: May 2011

Tomaino J, Keegan T, Kerkar N, Facciuto M, Miloh T, Taouli B, Hurlet A, Weintraub J, Sejpal D, Arnon R. Recurrent intrahepatic pigmented stones after liver transplantation in a patient with hemoglobin SC disease: Case report and review of the literature.  Pediatr Transplantation 2011: 15: 519–524. © 2011 John Wiley & Sons A/S.Abstract:  Patients with hemoglobinopathies may have hepatic involvement, which if severe, can lead to chronic liver disease and a need for liver transplant. Here, we present a case of a 16‐yr‐old female adolescent who presented to our center with hemoglobin SC disease, obstructive jaundice because of pigmented intrahepatic biliary stones, and progressive liver disease. She underwent a successful liver transplant but a few years later, she developed recurrent cholangitis and graft dysfunction because of recurrent intrahepatic biliary stones. Recurrent formation of intrahepatic stones after liver transplant is a rare and severe complication in patients with hemoglobinopathies. We recommend hypertransfusion therapy and surveillance imaging studies after liver transplant for early detection and prevention of this complication.
In vitro antifungal evaluation and structure–activity relationship of diphenyl diselenide and synthetic analogues
Authors: Loreto Érico Silva , Nunes Mario Débora Alves , Santurio Janio Morais , Alves Sydney Hartz , Nogueira Cristina Wayne , Zeni Gilzon 
Published: May 2011

SummaryWe report on in vitro antifungal activity and the structure–activity relationship of diphenyl diselenide [(PhSe)2] and its synthetic analogues, (p‐Cl‐C6H4Se)2, (m‐CF3‐C6H4Se)2 and (p‐CH3O‐C6H4Se)2, against 116 strains of pathogenic fungi. (PhSe)2 showed the highest inhibitory activity against Candida albicans (minimum inhibitory concentration of 4–32 μg ml−1), Candida dubliniensis (2–16 μg ml−1), Aspergillus spp. (0.5–64 μg ml−1) and Fusarium spp. (2–16 μg ml−1). Its minimum fungicidal concentration (MFC) varied among C. albicans (4–64 μg ml−1), C. dubliniensis (2–32 μg ml−1) and Fusarium spp. (4–64 μg ml−1). Antifungal activity was decreased by the introduction of functional groups to the (PhSe)2 molecule: (PhSe)2 > (p‐CH3O‐C6H4Se)2 > (m‐CF3‐C6H4Se)2 > (p‐Cl‐C6H4Se)2.
Effect of Preventive Intrauterine Ozone Application on Reproductive Efficiency in Holstein Cows
Authors: Djuricic D , Vince S , Ablondi M , Dobranic T , Samardzija M 
Published: May 2011

ContentsThe aim of the research was to determine the influence of preventive application of two different ozone preparations on reproductive efficiency in dairy cows with physiological puerperium. The research was conducted on 404 Holstein cows aged 2–8 years, divided into three groups. The first group consisted of cows treated using 6 intrauterine ozone pearls (RIPROMED OVULI O3®, Novagen, Italy) at once. The second group consisted of cows treated with ozone foam spray (RIGER SPRAY®, Novagen, Italy) application in the body of uterus for 5 s, and the third group was the control group. Cows from the first two groups were observed and treated during early puerperium, 24–48 h after parturition. To assess the reproductive performance of Holstein cows, interval from calving to first insemination (days open to first service, DOFS), interval from calving to pregnancy (days open to pregnancy, DOP), relative pregnancy rate (%), first service conception rate (FSCR, %) and all service conception rate (ASCR, %) were measured. The estimate of hazard ratio (HR) for group B relative to group C for DOFS was 0.62 (p = 0.0002), implying that the relative rate of first service decreased in the control group by 38%. The estimate of HR for group B relative to group C for DOP was 0.65 (p = 0.0006), implying that the relative rate of pregnancy decreased in group C by 35%. Cows treated with Riger spray (group B) became pregnant earlier and had better FSCR and ASCR. It is supposed that the form of ozone preparations and the amount of active substance were decisive. A conclusion may be made that preventive ozone intrauterine application during early puerperal period, especially the foaming form of ozone preparations (spray), improved the reproductive efficacy in dairy cows.
Basic FGF Promotes Proliferation of Ovarian Granulosa Cells in the Laying Chickens Via FGFR1 and PKC Pathway
Authors: Lin J , Jia Y , Zeng W , Mi Y , Zhang C 
Published: May 2011

ContentsThe proliferating effect of basic fibroblast growth factor (bFGF) on granulosa cells from ovarian pre‐hierarchical follicles was evaluated in the laying chickens. Expression of bFGF receptor 1 (FGFR1) from small yellow follicles was determined by immunohistochemistry and RT‐PCR. The FGFR1 protein and mRNA were intensively expressed in the granulosa layer. After 8‐ to 24‐h treatment with bFGF (0.1–100 ng/ml), the proliferation of cultured granulosa cells was remarkably enhanced in a dose‐ and time‐dependent manner. The FGFR1 antagonist SU5402 inhibited bFGF‐induced cell proliferation. This stimulating effect was further confirmed by 5‐bromo‐2‐deoxyuridine incorporation and terminal transferase dUTP nick end‐labelling assay. Immunocytochemistry of protein kinases A (PKA) and C (PKC) showed that the pro‐proliferation action of bFGF predominantly activated PKC expression. Meanwhile, the bFGF‐induced cell proliferation was significantly promoted by PKC activator PMA and inhibited by PKC inhibitor H7 (p < 0.05). In addition, the bFGF‐elicited cell proliferation was accompanied with increased mRNA expression of the cell cycle‐regulating genes including cyclins D1 and E1, cyclin‐dependent kinases 2 and 6. In conclusion, bFGF promoted the proliferation of ovarian granulosa cells through binding with FGFR1 and involving PKC pathway in the pre‐hierarchical follicles of the laying chickens.
Effect of an acute mechanical stimulus on aortic structure in the transverse aortic constriction mouse model
Authors: Chen Jing , Wu Jian , Li Lei , Zou Yun‐Zeng , Zhu Ding‐Liang , Gao Ping‐Jin 
Published: May 2011

Summary1. Vascular remodelling is an adaptive response to various stimuli, including mechanical forces, inflammatory cytokines and hormones. In the present study, we investigated histological modification of the aorta and the expression of key proteins participating in vascular remodelling under an acute mechanical stimulus using a transverse aortic constriction (TAC) mouse model.2. The TAC was performed in male C57BL/6 mice aged 10–12 weeks. A Millar conductance catheter was used to measure cardiac haemodynamic parameters 3 and 14 days after TAC. Aortic structural variations were observed by haematoxylin and eosin, Sirius red and Weigert’s elastin staining. Protein levels of Type I collagen, F4/80, α‐smooth muscle actin (SMA) and SM22α were analysed by immunohistochemistry.3. Three days after TAC, the medial area proximal to the aortic band (PA‐B) was increased, whereas the area distal to the aortic band (DA‐B) was unchanged. There was no difference in luminal area between TAC and sham groups. The adventitia displayed the most significant difference 14 days after TAC: adventitial hyperplasia was abundant and collagen was upregulated in the adventitia of the PA‐B with a considerable increase in α‐SMA and SM22α. Macrophages accumulated in the adventitia of the PA‐B 3 days after TAC and infiltrated into the media and intima of the PA‐B 14 days after TAC.4. In conclusion, the aortic structure undergoes considerable remodelling following an acute mechanical stimulus in the TAC model, mainly in the adventitia. Upregulation of α‐SMA and extracellular matrix components accompanied by macrophage infiltration may contribute to adventitial modification in the TAC mouse model.
Mismatch repair status in sporadic colorectal cancer: Immunohistochemistry and microsatellite instability analyses
Authors: Yoon Yong Sik , Yu Chang Sik , Kim Tae Won , Kim Jong Hoon , Jang Se Jin , Cho Dong Hyung , Roh Seon Ae , Kim Jin Cheon 
Published: May 2011

AbstractBackground and Aim:  The aim of the present study was to evaluate associations between mismatch repair (MMR) status and clinicopathological characteristics and prognosis using immunohistochemistry (IHC) and microsatellite instability (MSI) analyses in a prospective cohort of a large number of accumulated samples.Methods:  Tumor tissue samples obtained during curative surgery (n = 2028) were analyzed using both MLH1/MSH2 IHC and MSI assays. Clinicopathological parameters and survival outcomes were compared according to IHC and MSI results. The median follow‐up period was 43 months (range: 1–85 months).Results:  IHC identified 207 tumor samples (10.2%) with a loss of either MLH1 or MSH2 expression. The MSI analysis identified 203 tumor samples (10%) with high‐frequency MSI (MSI‐H). Patients with MMR defects were younger, and had tumors characterized by right‐colon predilection; large‐size, infrequent lymph node metastasis; poorly‐differentiated or mucinous histology, and synchronous adenomas (P < 0.001–0.008). Patients with MSI‐H status had higher 4‐year disease‐free survival rates than patients with microsatellite stable status (90.8% vs 80.6%, P = 0.001). A multivariate analysis showed that MSI‐H status was a good prognostic factor for recurrence (hazard ratio: 0.48, 95% confidence interval: 0.30–0.83, P = 0.007).Conclusions:  Patients with MMR defects had distinct clinicopathological characteristics, including a lower risk of recurrence. IHC and MSI analyses provided complementary information regarding specific clinicopathological parameters and prognosis.
Which should go first during same‐day bidirectional endosocopy with propofol sedation?
Authors: Hsieh Yu‐Hsi , Lin Hwai‐Jeng , Tseng Kuo‐Chih 
Published: May 2011

AbstractBackground and Aim:  Same‐day bidirectional endoscopy, including esophagogastroduodenoscopy (EGD) and colonoscopy, is frequently performed to screen for cancer and gastrointestinal bleeding. However, the optimal sequence for the procedures is unclear thus far. The aim of this study was to evaluate the optimal sequence for same‐day bidirectional endoscopy.Methods:  Consecutive patients undergoing same‐day bidirectional endoscopy under propofol sedation were randomized to either the colonoscopy‐first group (colonoscopy followed by EGD, n = 87) or the EGD‐first group (EGD followed by colonoscopy, n = 89). We evaluated the propofol dose, procedure duration, patient tolerance and recovery, adverse events, and endoscopic findings. The patient tolerance was assessed with a 0–10 visual analog scale.Results:  Total procedure times, patients' tolerance and recovery, adverse events, and endoscopic findings were similar between the two groups. The total propofol dose was significantly higher for the colonoscopy‐first group than for the EGD‐first group (mean 95% credibility limit: 135.7 [70–201.4] mg vs 124.7 [64.1–185.3] mg, respectively, P = 0.024). Patients in the colonoscopy‐first group moved significantly more during colonoscopy than those in the EGD‐first group: 1.1 (0–3.8) versus 0.6 (0–2.9) scores, respectively (P = 0.024).Conclusion:  The optimal sequence for same‐day bidirectional endoscopy is EGD followed by colonoscopy. In this order, the procedure is better tolerated, and patients require a lower overall dose of propofol.
Impact of introduction of wire‐guided cannulation in therapeutic biliary endoscopic retrograde cholangiopancreatography
Authors: Nakai Yousuke , Isayama Hiroyuki , Tsujino Takeshi , Sasahira Naoki , Hirano Kenji , Kogure Hirofumi , Sasaki Takashi , Kawakubo Kazumichi , Yagioka Hiroshi , Yashima Yoko , Mizuno Suguru , Yamamto Keisuke , Arizumi Toshihiko , Togawa Osamu , Matsubara Saburo , Yamamoto Natsuyo , Tada Minoru , Omata Masao , Koike Kazuhiko 
Published: May 2011

AbstractBackground and Aim:  Wire‐guided cannulation (WGC) might increase the biliary cannulation rate and decrease the risk of post‐endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis (PEP). We assessed the learning curve for WGC in therapeutic biliary ERCP (study 1) and compared WGC and conventional contrast‐assisted cannulation (CC) by a matched case‐control study (study 2).Methods:  Prospectively collected data of 500 therapeutic biliary ERCP cases (250 consecutive cases of WGC and 250 matched controls of CC) were retrospectively studied. Rate and time of biliary cannulation, total procedure time, PEP, and hyperamylasemia were analyzed.Results:  In study 1, biliary cannulation by WGC was successful in 96% of the first 50 cases, with a median time to cannulation of 3 min. Rates of hyperamylasemia were within 10% after 100 WGC. In study 2, there were no significant differences in the overall cannulation rate and PEP between WGC and CC, but the total procedure time was shorter in WGC (30 vs 35 min, P = 0.059). Rates of hyperamylasemia and the change in serum amylase levels was lower (9% vs 14%, P = 0.069, and + 62.8 U/L vs+ 169.5 U/L, P = 0.043) in WGC, which was more prominent in experienced endoscopists (9% vs 17%, P = 0.025, and + 68.9 U/L vs+ 229.3 U/L, P = 0.014).Conclusions:  The introduction of WGC was effective in the first 50 cases and did not increase the rate of PEP in biliary therapeutic ERCP.
Prostatic abscess caused by community‐acquired methicillin‐resistant Staphylococcus aureus
Authors: Park Seung Chol , Lee Jea Whan , Rim Joung Sik 
Published: May 2011

AbstractProstatic abscess is uncommon and difficult to diagnose, because its clinical presentation mimics lower urinary tract symptoms. Prostatic abscess is often caused by gram‐negative organisms and occasionally by Staphylococcus aureus. Community‐acquired methicillin‐resistant S. aureus (MRSA) often causes skin and soft‐tissue infections, and rarely causes genitourinary infections. We report what we believe is the second case of a prostatic abscess as a result of MRSA in a healthy diabetic patient who was treated with transurethral resection of the prostate and intravenous administration of vancomycin.
Dynamic prediction of metastases after radical prostatectomy for prostate cancer
Authors: Inman Brant A. , Frank Igor , Boorjian Stephen A. , Akornor Joseph W. , Karnes R. Jeffrey , Leibovich Bradley C. , Blute Michael L. , Bergstralh Eric J. 
Published: May 2011

Study Type – Prognosis (retrospective cohort)Level of Evidence 2aWhat’s known on the subject? and What does the study add?One of two problems plagues virtually are existing post‐prostatectomy prediction tools: either (1) they predict PSA recurrences (which are of unclear importance) or (2) the predictions they make are anchored at the date of surgery and are not updated based on how patients evolve over the postoperative years.Our prediction tool is a significant improvement over existing prediction tools in that it predicts the development of metastases which is a very important clinical endpoint that indicates incurable prostate cancer. Additionally, our tool allows for updated predictions at any point following radical prostatectomy by considering commonly available postoperative information (postoperative serum PSA and use of adjuvant therapies) to modify its risk predictions. The net result is a dynamic tool that renders clinically relevant predictions that change as the patient’s clinical status changes throughout the postoperative course.OBJECTIVE• To develop a dynamic algorithm that predicts the risk of metastases from any time point after radical prostatectomy (RP).PATIENTS AND METHODS• The study cohort consisted of 5741 RP patients who were treated from 1990–99.• Patients were grouped into one of four clinical states at follow‐up: State1, prostate‐specific antigen (PSA) undetectable; State2, PSA 0.15–0.39 ng/mL; State3, PSA ≥0.4 ng/mL; and State4, previous androgen deprivation or radiation therapy.• Follow‐up epochs (alive and at risk of systemic progression) at 0, 2, 4 and 6 years post‐RP, cumulative incidence curves and multistate Cox models were used to assess the risk of metastases over the ensuing 5‐year interval.• Gleason score, seminal vesicle and surgical margin involvement, and PSA variables were evaluated as predictors.RESULTS• Median follow‐up was 11.7 years, with 4411, 4256 and 3983 patients followed with PSA at 2, 4 and 6 years, respectively.• In total, 287 metastatic events occurred and the 5‐year risk of metastasis was 0.4%, 2.1%, 8.7% and 12.6% for men in States 1, 2, 3 and 4, respectively.• Independent predictors of metastasis by group included seminal vesicle involvement (all groups), Gleason score (groups 1, 3 and 4), current PSA (groups 3 and 4) and maximum past PSA (group 4).CONCLUSIONS• We present a web‐based prognostic tool for patients undergoing RP that is valid at many time points after surgery.• Our tool predicts the development of metastases.