bluuebunny/crossref_metadata_2025_split huggingface dataset:
Fruit and vegetable intake and the risk of non-alcoholic fatty liver disease: a meta-analysis of observational studies
Authors: Wang Rui , Yan Ruijuan , Jiao Junzhe , Li Feilong , Zhang Haibo , Chang Zhanjie , Wei Hailiang , Yan Shuguang , Li Jingtao 
Published: June 2024

PurposeThis systematic review and meta-analysis of clinical observational studies aims to clarify the correlation between the intake levels of fruits and vegetables and non-alcoholic fatty liver disease (NAFLD).Materials and methodsPubMed, Embase, Web of Science, and the Cochrane Library were searched for studies on the association between vegetable or fruit intake with the risk of NAFLD from the foundation of each database up until September 2023. The relative risk (OR) and the 95% confidence interval (CI) were pooled for both the highest and lowest consumption levels of vegetables and fruits to explore their association with the incidence of NAFLD.ResultsThe meta-analysis encompassed 11 studies with a total of 493,682 patients. A higher consumption of vegetables (OR = 0.78, 95% CI = 0.67–0.91) and fruits (OR = 0.88, 95% CI = 0.83–0.93) was found to have a negative correlation with the risk of NAFLD, denoting an inverse association. This correlation, however, varied among different ethnic groups and gender.ConclusionsOur results indicate that increased consumption of vegetables and fruits is associated with a reduced likelihood of developing NAFLD.Systematic review registrationhttps://www.crd.york.ac.uk/PROSPERO/#searchadvanced, identifier: CRD42023460430.
EGFR kinase domain duplication in lung adenocarcinoma with systemic and intracranial response to a double-dose of furmonertinib: a case report and literature review
Authors: Lin Hong , Yang Zhengyuan , Li Zhifeng , Chen Junwei , Wang Hongbiao , Lin Yingcheng 
Published: June 2024

BackgroundEGFR kinase domain duplication (EGFR-KDD) is an infrequent oncogenic driver mutation in lung adenocarcinoma. It may be a potential target benefit from EGFR-tyrosine kinase inhibitors (TKIs) treatment.Case presentationA 66-year-old Chinese male was diagnosed with lung adenocarcinoma in stage IVb with brain metastases. Next-generation sequencing revealed EGFR-KDD mutation. The patient received furmonertinib 160mg daily for anti-cancer treatment and obtained therapeutic efficacy with partial response (PR). Progression-free survival (PFS) duration from monotherapy was 16 months. With slow progressions, combined radiotherapy and anti-vascular targeted therapy also brought a continuous decrease in the tumors. The patient has an overall survival (OS) duration of more than 22 months and still benefits from double-dose furmonertinib.ConclusionsThis report provided direct evidence for the treatment of EGFR-KDD to use furmonertinib. A Large-scale study is needed to confirm this preliminary finding.
BRCA-associated hereditary male cancers: can gender affect the prevalence and spectrum of germline pathogenic variants?
Authors: Fanale Daniele , Corsini Lidia Rita , Brando Chiara , Randazzo Ugo , Bono Marco , Pedone Erika , Perez Alessandro , Sciacchitano Roberta , Cancelliere Daniela , Piraino Paola , Giurintano Ambra , Bazan Russo Tancredi Didier , Ferraro Pietro , Rinaldi Gaetana , Spinnato Valeria , Gennusa Vincenzo , Pernice Gianfranco , Vieni Salvatore , Pantuso Gianni , Russo Antonio , Bazan Viviana 
Published: June 2024

IntroductionAlthough hereditary male neoplasms are quite rare, individuals harbouring germline BRCA1/2 pathogenic variants (PVs) may have a risk of developing tumours associated with Hereditary Breast and Ovarian Cancer (HBOC) syndrome, including male breast (MBC), prostate (PCa) and pancreatic (PC) cancers, and melanoma. Women and men showed a comparable genetic architecture of cancer susceptibility, but there are some gender-specific features. Since little is known about cancer genetic susceptibility in male population, our study was aimed at investigating the frequency of BRCA1/2 PVs in men with HBOC syndrome-associated tumors, in order to understand whether differences in gender may reflect in the prevalence and spectrum of germline alterations.Patients and methodsWe retrospectively collected and analysed clinical information of 352 HBOC-associated male cancer patients genetically tested for germline BRCA1/2 PVs by Next-Generation Sequencing analysis, enrolled, from February 2018 to January 2024, at the “Regional Center for the prevention, diagnosis and treatment of rare and heredo-familial tumors of adults” of the University-Hospital Policlinico “P. Giaccone” of Palermo (Italy).ResultsOur investigation revealed that 7.4% of patients was carrier of a germline BRCA PV, with an almost total prevalence of BRCA2 alterations. In particular, 65.4% of BRCA-positive patients developed MBC, 19.2% had PC, 11.6% developed PCa, and only 3.8% had melanoma. Specifically, MBC individuals showed a BRCA-associated genetic predisposition in 17% of cases, whereas patients with PCa or PC exhibited a lower frequency of BRCA2 PVs, taking into account the current national criteria for access to germline genetic testing.DiscussionOur study showed a high heterogeneity in prevalence of germline BRCA2 PVs among men which could reflect a potential gender-specific genetic heterogeneity. Therefore, BRCA-associated male tumours could be due to BRCA2 PVs different from those usually detected in women. In the event that it is demonstrated, in future, that male cancers are genetically distinct entities from those female this could improve personalized risk evaluation and guide therapeutic choices for patients of both sexes, in order to obtain a gender equality in cancer care.
A scientometric analysis of research on the role of NMDA receptor in the treatment of depression
Authors: Chen Xulin , Wang Xian , Li Caijuan , Zhang Yao , Feng Shanwu , Xu Shiqin 
Published: June 2024

BackgroundThere have been numerous studies on NMDA receptors as therapeutic targets for depression. However, so far, there has been no comprehensive scientometric analysis of this field. Thus, we conducted a scientometric analysis with the aim of better elucidating the research hotspots and future trends in this field.MethodsPublications on NMDAR in Depression between 2004 and 2023 were retrieved from the Web of Science Core Collection (WoSCC) database. Then, VOSviewer, CiteSpace, Scimago Graphica, and R-bibliometrix—were used for the scientometric analysis and visualization.Results5,092 qualified documents were identified to scientometric analysis. In the past 20 years, there has been an upward trend in the number of annual publications. The United States led the world in terms of international collaborations, publications, and citations. 15 main clusters were identified from the co-cited references analysis with notable modularity (Q-value = 0.7628) and silhouette scores (S-value = 0.9171). According to the keyword and co-cited references analysis, treatment-resistant depression ketamine (an NMDAR antagonist), oxidative stress, synaptic plasticity, neuroplasticity related downstream factors like brain-derived neurotrophic factor were the research hotspots in recent years.ConclusionAs the first scientometric analysis of NMDAR in Depression, this study shed light on the development, trends, and hotspots of research about NMDAR in Depression worldwide. The application and potential mechanisms of ketamine in the treatment of major depressive disorder (MDD) are still a hot research topic at present. However, the side effects of NMDAR antagonist like ketamine have prompted research on new rapid acting antidepressants.
Insecticidal activity and underlying molecular mechanisms of a phytochemical plumbagin against Spodoptera frugiperda
Authors: Sun Xiaoyu , Li Wenxuan , Yang Shuang , Ni Xueqi , Han Shengjie , Wang Mengting , Zhen Cong’ai , Huang Xinzheng 
Published: June 2024

IntroductionPlumbagin is an important phytochemical and has been reported to exhibit potent larvicidal activity against several insect pests, However, the insecticidal mechanism of plumbagin against pests is still poorly understood. This study aimed to investigate the insecticidal activities of plumbagin and the underlying molecular mechanisms against a devastating agricultural pest, the fall armyworm Spodoptera frugiperda.MethodsThe effects of plumbagin on S. frugiperda larval development and the activities of two detoxification enzymes were initially examined. Next, transcriptomic changes in S. frugiperda after plumbagin treatment were investigated. Furthermore, RNA-seq results were validated by qPCR.ResultsPlumbagin exhibited a high larvicidal activity against the second and third instar larvae of S. frugiperda with 72 h LC50 of 0.573 and 2.676 mg/g, respectively. The activities of the two detoxification enzymes carboxylesterase and P450 were significantly increased after 1.5 mg/g plumbagin treatment. Furthermore, RNA-seq analysis provided a comprehensive overview of complex transcriptomic changes in S. frugiperda larvae in response to 1.5 mg/g plumbagin exposure, and revealed that plumbagin treatment led to aberrant expression of a large number of genes related to nutrient and energy metabolism, humoral immune response, insect cuticle protein, chitin-binding proteins, chitin synthesis and degradation, insect hormone, and xenobiotic detoxification. The qPCR results further validated the reproducibility and reliability of the transcriptomic data.DiscussionOur findings provide a valuable insight into understanding the insecticidal mechanism of the phytochemical plumbagin.
A comparison of perceptual-cognitive skills in expert and non-expert sports officials: a systematic review and meta-analysis
Authors: Wu Yidong , Yang Ziqi , Wang Rishu , Zeng Hongtao , Zhang Qi 
Published: June 2024

IntroductionThe purpose of this study is to systematically compare and assess the differences in perceptual-cognitive skills between expert and non-expert sports officials, and further explore the potential differences caused by different types of sports officials, in order to provide a more comprehensive understanding of the perceptual-cognitive skills of sports officials.MethodsRelevant literature published before 31 December 2022 was searched in four English databases. Review Manager 5.4 and Stata 12.0 software were used for meta-analysis and bias test.ResultsExpert sports officials are significantly more accurate in their decision-making than non-expert sports officials, and exhibit a large amount of effect size (SMD = 1.09; 95%CI: 0.52, 1.66; P &lt; 0.05). Expert sports officials had significantly fewer number of fixations than non-expert sports officials and showed a moderate amount of effect size (SMD = 0.71; 95%CI: 1.25, 0.17; P &lt; 0.05). Expert sports officials' duration of fixation (SMD = 0.23; 95%CI: 0.25, 0.71; P = 0.35) were not significantly different from non-expert sports officials.DiscussionIt can be seen that there are differences in the Perceptual-cognitive skills of expert and non-expert sports officials. Decision-making accuracy can serve as an important indicator for distinguishing the perceptual-cognitive skills of expert and non-expert sports officials. Number of fixations can serve as important indicators to differentiate the perceptual-cognitive skills of monitors.Systematic review registrationhttps://www.crd.york.ac.uk/PROSPERO/display_record.php?RecordID=418594, identifier: CRD42023418594.
The methods and baseline characteristics of a multi-site randomized controlled trial evaluating mindfulness-based relapse prevention in conjunction with peer support to improve adherence to medications for opioid use disorders
Authors: Mumba Mercy Ngosa , Mugoya George Tongi , Allen Rebecca S. , Glenn Andrea L. , Richman Joshua , Ghera Anchal , Butler Austin , Rogers Blossom , Granger Teresa Ann , Davis Lori L. 
Published: June 2024

IntroductionMedications for opioid use disorders (MOUD) remain the gold standard for treating OUD, but treatment initiation and adherence remain challenging. Exclusive utilization of pharmacotherapy as a treatment modality for OUD is sub-optimal, and a combination of psychotherapies and pharmacotherapies is recommended. General trends indicate the benefits of peer mentoring and MBRP separately. Therefore, we hypothesize that the combined effect of MBRP and Peer mentoring will produce synergistic improvements in MOUD adherence compared to an enhanced twelve-step facilitation (TSF).MethodsThis paper describes the methods and baseline characteristics of a multi-site randomized controlled trial evaluating the effectiveness of a combination of MBRP and peer support (MiMP) compared to an enhanced TSF in improving adherence to MOUD. Both MiMP and TSF are 12-week manualized protocols that utilize licensed therapists. The interventions are delivered in weekly group sessions that last about 75–90 minutes per session. The primary outcome is MOUD adherence. Secondary and exploratory outcomes include relapse, cravings, depression, anxiety, stress, quality of life, and pain catastrophizing.ResultsThe participants’ ages ranged from 21 years to 77 years, with a mean age of 44.5 (SD ± 11.5 years). There was an almost equal distribution of gender and place of residence. Overall, 51.9% (n=54) of participants identified as female and 48.1% (n=50) were male. Similarly, 51.9% (n=54) of participants resided in urban areas, while 48.1% (n=50) resided in rural areas. Participants identified as either black or white, with over three-quarters identifying as white (77.9%, n= 81) and 22.1% (n= 23) as black. Most participants randomized to the 12-step facilitation group were white (93.1%). Relationships and employment status were well distributed between categories. Over half of the participants reported some college or higher education. Over 90% of the participants made less than $75,000 per year. Some participants indicated that they had both public and private health insurance.Discussion and conclusionThis study is innovative in several ways including combining MBRP and peer support, addressing comorbid mental health issues among individuals with OUD, utilizing manualized protocols, and evaluating of both physiological and self-reported measures in assessing cortisol reactivity as a predictor of relapse and treatment outcomes.
Minding mentalizing - convergent validity of the Mentalization Breakdown Interview
Authors: Ulvestad Dag Anders , Johansen Merete Selsbakk , Kvarstein Elfrida Hartveit , Pedersen Geir , Wilberg Theresa 
Published: June 2024

ObjectivesMentalizing difficulties are central to borderline personality disorder (BPD), have severe consequences, and are an explicit focus in mentalization-based treatment. The significance of mentalizing capacity as a predictor or mediator of change is however still uncertain due to a scarcity of research. The Mentalization Breakdown Interview (MBI) was developed as a time saving tool for studying psychotherapy processes and outcome in borderline pathology. This study aimed to investigate the convergent validity of reflective functioning (RF) ratings based on the MBI (MBI-RF) by a comparison with the gold standard, i.e., RF assessments based on the Adult Attachment Interview (AAI-RF). A secondary aim was to investigate how MBI-RF relates to core symptoms of BPD, levels of functional impairment and symptom distress compared with AAI-RF.MethodForty-five patients with BPD or significant BPD traits were included. MBI-RF and AAI-RF were rated using the Reflective Functioning Scale. Levels of MBI-RF and AAI-RF and the correlation between the measures were calculated, as well as their associations with the Difficulties in Emotion Regulation Scale, Levels of Personality Functioning-Brief Form 2.0, Work and Social Adjustment Scale, Patient Health Questionnaire, Depression, Generalized Anxiety Disorder-7, self-harm, suicide attempts, and PD diagnostics.ResultsThe correlation between MBI-RF and AAI-RF was 0.79 (p&lt;0.01), indicating high convergent validity. There were few significant associations between MBI-RF and AAI-RF and clinical measures.ConclusionsThe study provides support for the convergent validity of the MBI as a BPD-focused RF assessment method. The MBI has the potential as a time saving, reliable and valid method to be applied in treatment research on patients with borderline pathology. The results indicate that measures of MBI-RF and AAI-RF are different from clinical symptoms.Clinical trial registrationClinicalTrials.gov ID NCT04157907.
مدى إمكانية توظيف تكنولوجيا المعلومات والاتصالات في تنمية الإبداع الإداري لدى القادة التربويين بمديريات التربية والتعليم في سلطنة عمان
Authors: محمد علي عاشور  
Published: June 2024

هدفت هذه الدراسة التعرف على مدى إمكانية توظيف تكنولوجيا المعلومات والاتصالات في تنمية الإبداع الإداري لدى القادة التربويين بمديريات التربية والتعليم في سلطنة عمان، كما هدفت الدراسة إلى التعرف على ما إذا كان هناك فروق ذات دلالة إحصائية في مدى إمكانية توظيف تكنولوجيا المعلومات والاتصالات في تنمية الإبداع الإداري لدى القادة الإداريين بمديريات التربية والتعليم في سلطنة عمان تعزى لمتغيرات الجنس، ومسمى الوظيفة، والمؤهل العملي، وسنوات الخبرة العملية والمنطقة التعليمية.
تم اختيار عينة عشوائية طبقية بلغت (286) أي ما نسبته (52,77) من العدد الكلي لأفراد مجتمع الدراسة. ولتحقيق أهداف الدراسة، تم تطوير استبانة اشتملت على (53) فقرة موزعة على خمسة مجالات هي: عملية اتخاذ القرارات، والمهارات والقدرات الإدارية، والاتصالات الإدارية، وتوافر قواعد البيانات والمعلومات، والرقابة والمتابعة الإداريةـ تم استخدام المتوسطات الحسابية والانحرافات المعيارية على كل مجال من مجالات الدراسة، واختبار (ت) وشيفيه، كذلك تحليل التباين الأحادي واختبار LSD.
توصلت الدراسة إلى النتائج التالية:
-	يمكن توظيف تكنولوجيا المعلومات والاتصالات من قبل القادة التربويين في مديريات التربية والتعليم وبإمكانية كبيرة.
-	جاء ترتيب مجالات الدراسة في مدى إمكانية توظيف تكنولوجيا المعلومات والاتصالات لدي القادة التربويين وفق الترتيب الآتي: تحسين المهارات والقدرات الإدارية، يليه الاتصالات الإدارية، ثم توافر قواعد البيانات والمعلومات، ثم عملية اتخاذ القرارات، وجاء في المرتبة الأخيرة الرقابة والمتابعة الإدارية.
-	وجود فروق ذات دلالة إحصائية على جميع مجالات الدراسة لصالح الذكور، ومدير دائرة، وسنوات الخبرة أكثر من عشرة سنوات، ولصالح منطقة مسندم، وحملة الدبلوم.
-	حصل المقترح “توسيع وتبسيط قاعدة المشاركة في اتخاذ القرارات الإدارية“ على اعلى نسبة وبدرجة مساهمة كبيرة.
Integrated Mini-Pillar Platform for Wireless Real-Time Cell Monitoring
Authors: Luo Yong , Song Yongchao , Wang Jing , Xu Tailin , Zhang Xueji 
Published: June 2024

Cell culture as the cornerstone of biotechnology remains a labor-intensive process requiring continuous manual oversight and substantial time investment. In this work, we propose an integrated mini-pillar platform for in situ monitoring of multiple cellular metabolism processes, which achieves media anchoring and cell culture through an arrayed mini-pillar chip. The assembly of polyaniline (PANI)/dendritic gold-modified microelectrode biosensors exhibits high sensitivity (63.55 mV/pH) and excellent interference resistance, enabling real-time acquisition of biosensing signals. We successfully employed such integrated devices to real-time measuring pH variations in multiple cells and real-time monitoring of cell metabolism under drug interventions and to facilitate in situ assisted cultivation of 3-dimensional (3D) cell spheroids. This mini-pillar array-based cell culture platform exhibits excellent biosensing sensitivity and real-time monitoring capability, offering considerable potential for the advancement of biotechnology and medical drug development.
ВПЛИВ ЦИФРОВІЗАЦІЇ НА ЗАБЕЗПЕЧЕННЯ ІНФОРМАЦІЙНОЇ БЕЗПЕКИ: НОВІ ЗАГРОЗИ В СИСТЕМІ ДЕРЖАВНОГО УПРАВЛІННЯ
Authors: Богоніс Андрій 
Published: June 2024

Дослідження присвячене характеристиці особливостей впливу цифровізації на забезпечення інформаційної безпеки в системі державного управління. Доведено, що сьогодні значні представники інтелектуальної, політичної та економічної еліти світу активно долучені до формування глобального та європейського інформаційного суспільства. Встановлено, що інформаційні технології та інформаційно-комунікативні системи є ключовими в умовах сучасного цивілізаційного розвитку, виступаючи не лише як важливі елементи для розвитку держави та суспільства, але й як необхідна умова їхньої конкурентоспроможності на глобальному рівні. Інформаційний сектор відіграє провідну роль у реалізації соціальних ініціатив, зміцненні громадянського суспільства та інтеграції у світове співтовариство. Доведено, що ефективність забезпечення інформаційної безпеки вимірюється здатністю підтримувати високий рівень безпеки інформаційної сфери при мінімальних витратах. Різноманіття внутрішніх і зовнішніх інформаційних загроз може порушити стабільність системи державного управління. Інформаційна безпека є індикатором стабільного стану системи державного управління, здатної зберігати ключові функції під час впливу загроз. Визначено, що серед основних завдань системи забезпечення інформаційної безпеки — створення умов для забезпечення інформаційного суверенітету, вдосконалення нормативно-правової бази для розвитку національної інформаційної інфраструктури, впровадження сучасних технологій, забезпечення достовірної інформації та сприяння мас-медіа у боротьбі з корупцією. Також важливим є гарантування конституційного права на свободу слова, доступ до інформації та захист даних від неправомірного втручання державних структур. Доведено, що цифровізація відіграє ключову роль у зміцненні інформаційної безпеки, підвищуючи ефективність, доступність і безпеку державних операцій. Вона сприяє централізації даних, забезпечує моніторинг у реальному часу та впровадження передових методів шифрування. Крім того, цифровізація є потужним інструментом, який може суттєво підвищити стійкість державних інституцій. Вона робить уряди більш стійкими до кіберзагроз, прозорими та підзвітними, а також дає їм можливість ефективно боротися з дезінформацією. Це, в свою чергу, веде до кращого урядування, зміцнення довіри між владою та суспільством та більш стійкого розвитку країни.
ANALISIS SEBARAN KONDISI DAERAH RESAPAN AIR MENGGUNAKAN SISTEM INFORMASI GEOGRAFIS DI KECAMATAN POASIA KOTA KENDARI
Authors: Hidayat Ahmad , Rusman La Ode , Haris Haris 
Published: June 2024

Peningkatan jumlah penduduk di Kecamatan Poasia berdampak pada meluasnya lahan terbangun. Hal ini dapat berpengaruh pada berkurangnnya daerah resapan air. Penelitian ini bertujuan untuk mengetahui sebaran kondisi daerah resapan air tahun 2017 dan 2021 di Kecamatan Poasia. Parameter yang digunakan untuk mengetahui kondisi resapan air pada penelitian ini, yaitu permeabilitas tanah, curah hujan, penggunaan lahan dan kemiringan lereng kemudian diolah menggunakan metode skoring, OBIA, dan overlay. Hasil penelitian ini antara lain kondisi resapan air tahun 2017 didominasi dengan kategori mulai kritis seluas 2.879,95 ha (67,11%), yang tersebar di Kelurahan Anduonuhu (1.482,81 ha), Kelurahan Anggoeya (985,75 ha) Kelurahan Rahandouna (169,53 ha), Kelurahan Wundumbatu (70,97 ha) dan Kelurahan Matabubu (170,89 ha), sedangkan kondisi resapan air dengan luasan paling kecil pada kategori agak kritis seluas 230,06 ha (5,36%) yang tersebar pada Kelurahan Anduonuhu seluas 156,03 ha, Kelurahan Anggoeya seluas 11,47 ha, Kelurahan Rahandouna seluas 2,04 ha, Kelurahan Wundumbatu seluas 59,43 ha dan Kelurahan Matabubu seluas 1,09 ha. Pada tahun 2021 kondisi resapan air didominasi kategori normal alami seluas 1.971,53 ha (45,94%) yang tersebar di Kelurahan Anduonuhu (774,49 ha), Kelurahan Anggoeya (619,82 ha), Kelurahan Rahandouna (124,07 ha), Kelurahan Wundumbatu (68,07 ha) dan Kelurahan Matabubu (385,08 ha), sedangkan kondisi resapan air dengan luasan paling kecil pada kategori sangat kritis seluas 111,42 ha (2,60%) yang tersebar di Kelurahan Anduonuhu seluas 64,54 ha, Kelurahan Anggoeya seluas 19,71 ha, Kelurahan Rahandouna seluas 27,04 ha dan Kelurahan Matabubu seluas 0,13 ha.