bluuebunny/crossref_metadata_2025_split huggingface dataset:
Antioxidant activity of sesame, rice bran and bene hull oils and their unsaponifiable matters
Authors: Farhoosh Reza , Tavassoli‐Kafrani Mohammad Hossein , Sharif Ali 
Published: October 2010

AbstractChemical composition of sesame (SEO), rice bran (RBO) and bene hull (BHO) oils was determined. During oven test, peroxide value on day 8 (PV8, meq/kg) and carbonyl value on day 6 (CV6, µmol/g) were considered as measures of resistance to the formation of primary and secondary oxidation products, respectively. The SEO and BHO showed statistically the same PV8 (381.4 and 359.8, respectively) and CV6 (25.2 and 25.8, respectively), and their stabilizing effect was significantly better than that of the RBO (455.5 and 32.7, respectively). The unsaponifiable matters (USM) fraction of the BHO (443.7 and 26.8, respectively) had an antioxidative effect higher than those of the SEO (478.0 and 38.6, respectively) and RBO (482.4 and 37.4, respectively). There was a good correlation (R2 = 0.972) between the PV8 and CV6 throughout oxidation period. On the basis of the oxidative stability index (OSI, h) of Rancimat test, the best carry‐through properties belonged to the SEO (6.92 h), followed by the RBO (6.12 h) and BHO (5.0 h), and also a similar order was observed for the USM fractions (5.89, 5.28 and 4.50 h, respectively). There was no correlation between the results of Rancimat and oven tests, showing that the powerful antioxidative agents under oven test conditions were lack of appropriate carry‐through properties. The highest significant reducing power (mmol/L) belonged to the SEO (258.1), followed by the RBO (218.7) and BHO (152.4), whereas the USM fraction of the SEO indicated the least significant quantity among the USM fractions (89.3 vs. 216.6 and 158.0 for the RBO and BHO, respectively).
A Cascade Annulation Based Convergent Approach to Racemic Tetrodotoxin
Authors: Cagide‐Fagín Fernando , Alonso Ricardo 
Published: October 2010

AbstractThe synthetic power of the recently developed cascade annulations of β‐(hetero)aryl‐α‐nitro‐α,β‐enals with the pyrrolidine‐derived enamine of 2,2‐dimethyl‐1,3‐dioxan‐5‐one is demonstrated by the first convergent route to (±)‐tetrodotoxin.
Hospital competition and inpatient services efficiency in Taiwan: a longitudinal study
Authors: Chu Chiao‐Lee , Chiang Tung‐liang , Chang Ray‐E 
Published: October 2010

SUMMARYThere is no consistent evidence of the relationship between market competition and hospital efficiency. Some studies indicated that more competition led to a faster patient turnover rate, higher hospital costs, and lower hospital efficiency. Since the 1980s some studies found market competition could increase the efficiency of inpatient services. However, there were few studies testing the market competition during a hospital's earlier stages on its efficiency during later stages, or the dynamic of efficiency. In this study, we examined the effect of early‐stage market competition on later‐stage hospital efficiency in Taiwan, and we determine the efficiency change using longitudinal study design. The data for the analysis came from the annual national hospital survey of 1996 and 2001 provided by the Department of Health. There were 102 teaching hospital be analysed. The results show that no evidence supports the proposition that higher market competition would improve the efficiency of hospitals in delivering inpatient services in Taiwan. Importantly, neither was the inefficiency score nor the Malmquist productivity index of inpatient services associated with the level of hospital market competition, regardless of the adjustment for hospital characteristics. However, the results may be related with the hospital increasing beds investment behavior. Copyright © 2010 John Wiley & Sons, Ltd.
Glucose and caffeine effects on sustained attention: an exploratory fMRI study.
Authors: Serra‐Grabulosa Josep M , Adan Ana , Falcón Carles , Bargalló Núria 
Published: October 2010

AbstractObjectiveCaffeine and glucose can have beneficial effects on cognitive performance. However, neural basis of these effects remain unknown. Our objective was to evaluate the effects of caffeine and glucose on sustained attention, using functional magnetic resonance imaging (fMRI).MethodsForty young right‐handed, healthy, low caffeine‐consuming subjects participated in the study. In a double‐blind, randomised design, subjects received one of the following beverages: vehicle (water, 150 ml); vehicle plus 75 g of glucose; vehicle plus 75 mg of caffeine; vehicle plus 75 g of glucose and 75 mg of caffeine. Participants underwent two scanning fMRI sessions (before and 30 min after of the administration of the beverage). A continuous performance test was used to assess sustained attention.ResultsParticipants who received combined caffeine and glucose had similar performance to the others but had a decrease in activation in the bilateral parietal and left prefrontal cortex.ConclusionsSince these areas have been related to the sustained attention and working memory processes, results would suggest that combined caffeine and glucose could increase the efficiency of the attentional system. However, more studies using larger samples and different levels of caffeine and glucose are necessary to better understand the combined effects of both substances. Copyright © 2010 John Wiley & Sons, Ltd.
Recent Advances in Boron Nitride Nanotubes and Nanosheets
Authors: Golberg Dmitri , Bando Yoshio , Huang Yang , Xu Zhi , Wei Xianlong , Bourgeois Laure , Wang Ming‐Sheng , Zeng Haibo , Lin Jing , Zhi Chunyi 
Published: October 2010

AbstractHerein the recent experiments performed by the authors on fabricated multi‐walled BN nanotubes and monoatomic BN graphene‐like nanosheets are reviewed. The results are presented in several sections, namely: (i) method for high‐yield synthesis of thin, defect‐free BN nanotubes of only a few‐layers, with external diameters below 10 nm; (ii) verification of BN nanotube piezoelectrical behavior and its electrically‐induced thermal decomposition under combined resistive heating and electrical charging in a transmission electron microscope; (iii) the first direct measurements of the true tensile strength and Young’s modulus of BN nanotubes, using newly developed nanotensile tests inside an electron microscope; the measured values were found to be ∼30 GPa and ∼900 GPa, respectively; and (iv) diverse kinetic processes taking place within the prepared monoatomic BN sheets (so‐called “white graphenes”) affiliated with intensive knock‐on B and N atom displacements under high energy electron beam irradiation in an aberration‐corrected medium‐voltage high‐resolution transmission electron microscope.
In vivo performance of titanium implants functionalized with eicosapentaenoic acid and UV irradiation
Authors: Petzold Christiane , Rubert Marina , Lyngstadaas S. Petter , Ellingsen Jan Eirik , Monjo Marta 
Published: October 2010

AbstractThe aim of this study was to design implant surfaces that attach less to bone but at the same time improve osseous healing for use as temporary bone fracture plates. The strategy was to combine the nonadhesive properties of smooth titanium (Ti) surfaces with the differentiative and anti‐inflammatory properties of eicosapentaenoic acid (EPA). Machined Ti implant surfaces coated with a layer of EPA, with or without UV irradiation, were characterized by X‐ray photoelectron spectroscopy, and their in vivo performance was evaluated in New Zealand White rabbits. The performance of the functionalised implants was analyzed after 10 weeks of healing by mechanical pull‐out testing, molecular biology, and histological and microcomputed tomography analysis. The results indicate that surface functionalization with UV light can reduce bone attachment and volumetric bone mineral density in the peri‐implant bone tissue. The presence of EPA on the surfaces enhanced this effect further. Gene expression of bone formation markers showed a trend toward higher mRNA levels in all EPA treated groups. The histological analyses demonstrated lower inflammation in the UV‐irradiated group and immature bone formation in all the groups. In conclusion, surface functionalization of Ti implants with UV light and EPA could be a biocompatible coating for reduced bone bonding ability of Ti while promoting bone formation. © 2010 Wiley Periodicals, Inc. J Biomed Mater Res Part A:, 2010.
Survival of porcine mesenchymal stem cells over the alginate recovered cellular method
Authors: Cohen Jonah , Zaleski Katherine L. , Nourissat Geoffroy , Julien Terrill P. , Randolph Mark A. , Yaremchuk Michael J. 
Published: October 2010

AbstractAlthough previous studies have established alginate as a three‐dimensional scaffold for chondrogenic differentiation of mesenchymal stem cells (MSCs), little is known about the cytotoxic effects of the polymerizing and chelating reagents used in the alginate recovered cellular method. Swine MSCs (sMSC) were suspended in the polymerizing agent, CaCl2, and viability was assessed using a trypan blue exclusion assay at intervals over 2 h. MSCs were also suspended in two different chelating agents, 55 mM sodium citrate and 50 mM EDTA, and viability was calculated. Finally, sMSCs and human MSCs were encapsulated and cultured in vitro. The sMSC were collected at day 4 and the cells were recovered by chelation. Encapsulated hMSCs were cultured with TGFβ3 and IGF‐1 and assayed by qRT‐PCR for collagen types I and II and sox9 with encapsulated human dermal fibroblasts and chondrocytes as controls recovered on days 0, 7, and 14. Only 53% of sMSCs were viable after 10 min in CaCl2, the standard polymerization period, whereas 94% of encapsulated sMSCs in polymerized alginate were alive at 15 days. After 20 min in chelating agents, sodium citrate and EDTA, only 46% and 17% of the cells, were viable, respectively. The alginate recovered sMSCs yielded 12% survival. Human MSCs upregulated cartilage‐specific collagen type II over the 14‐day culture. Collagen I remained unchanged in the hMSCs. Alginate is a suitable agent for chondrodifferentiation of MSCs and can be dissolved by chelation, but the agents involved in hydrogel polymerization and cell recovery should be altered to improve MSC survival. © 2010 Wiley Periodicals, Inc. J Biomed Mater Res Part A:, 2010.
Lentiviral vector‐mediated knockdown of the neuroglycan 2 proteoglycan or expression of neurotrophin‐3 promotes neurite outgrowth in a cell culture model of the glial scar
Authors: Donnelly Eleanor M. , Strappe Padraig M. , McGinley Lisa M. , Madigan Nicolas N. , Geurts Elizabeth , Rooney Gemma E. , Windebank Anthony J. , Fraher John , Dockery Peter , O'Brien Timothy , McMahon Siobhan S 
Published: October 2010

AbstractBackgroundFollowing spinal cord injury, a highly inhibitory environment for axonal regeneration develops. One of the main sources of this inhibition is the glial scar that is formed after injury by reactive astrocytes. The inhibitory environment is mainly a result of chondroitin sulphate proteoglycans (CSPGs). Neuroglycan 2 (NG2), one of the main inhibitory CSPGs, is up‐regulated following spinal cord injury.MethodsSmall interfering RNA (siRNA) was designed to target NG2 and this short hairpin RNA (shRNA) was cloned into a lentiviral vector (LV). The neurotrophic factor neurotrophin‐3 (NT‐3) promotes the growth and survival of developing neurites and has also been shown to aid regeneration. NT‐3 was also cloned into a LV. In vitro assessment of these vectors using a coculture system of dorsal root ganglia (DRG) neurones and Neu7 astrocytes was carried out. The Neu7 cell line is a rat astrocyte cell line that overexpresses NG2, thereby mimicking the inhibitory environment following spinal cord injury.Results and DiscussionThese experiments show that both the knockdown of NG2 via shRNA and over‐expression of NT‐3 can significantly increase neurite growth, although a combination of both vectors did not confer any additional benefit over the vectors used individually. These LVs show promising potential for growth and survival of neurites in injured central nervous system tissue (CNS). Copyright © 2010 John Wiley & Sons, Ltd.
A customizable plan for effective claims management
Authors: Irving Anne , Prager Adrienne , Standley Carolyn 
Published: October 2010

AbstractClaims administration is central to healthcare risk management. This article examines several key aspects of claims management and provides useful information for both new and experienced claims professionals. It offers tools and examples for inexperienced risk managers to master effective claims management practices and outlines suggestions that seasoned risk managers can use to update or validate their own processes. These claims management practices serve to protect the organization's assets and can be customized to meet each organization's needs.
Measuring and managing the economic impact of disruptive behaviors in the hospital
Authors: Rosenstein Alan H. 
Published: October 2010

AbstractDisruptive behaviors have been shown to have a significant negative impact on staff relationships, team collaboration, communication flow, and patient outcomes of care. They can be a major factor in contributing to the occurrence of adverse events that compromise quality care and patient safety and can put the patient and organization at increased risk. Whereas organizations generally are not reticent to make system enhancements designed to improve patient safety, they are more reluctant to address human factor issues such as disruptive behaviors for a variety of reasons. This article presents a 10‐step process for addressing both the economic and quality impact of disruptive behaviors in an attempt to stimulate a call to action.
Mandatory pre‐suit mediation: Local malpractice reform benefiting patients and healthcare providers
Authors: Jenkins Randall C. , Warren Lindsay A. , Gravenstein Nikolaus 
Published: October 2010

AbstractThe Florida Patient Safety and Pre‐Suit Mediation Program (FLPSMP) was implemented as a pilot program to provide patients of healthcare providers and facilities associated with the University of Florida Health Science Center with timely and fair compensation when injured and to combat rising healthcare legal liability expenses. Prior to filing a formal lawsuit, participants of the FLPSMP join in a confidential and nonbinding pre‐suit mediation conducted by a neutral third‐party mediator. The process fosters confidential and candid communication between doctors and patients, saving thousands of dollars in legal expenses for both patients and providers.
Knockout of ADAMTS5 does not eliminate cartilage aggrecanase activity but abrogates joint fibrosis and promotes cartilage aggrecan deposition in murine osteoarthritis models
Authors: Li Jun , Anemaet Wendy , Diaz Michael A. , Buchanan Samuel , Tortorella Micky , Malfait Anne Marie , Mikecz Katalin , Sandy John D. , Plaas Anna 
Published: October 2010

AbstractTo investigate the role of ADAMTS5 in murine osteoarthritis (OA), resulting from destabilization of the medial meniscus (DMM model) or from TGFb1 injection and enforced uphill treadmill running (TTR model). Wild‐type (WT) and ADAMTS5−/− mice were subjected to either DMM or TTR and joints were evaluated for meniscal damage, cartilage changes, and fibrotic ingrowths from the joint margins. Cartilage lesions were quantified on an 8‐point scoring system. Cartilage chondroitin sulfate (CS) content was evaluated by SafraninO staining and by quantitative electrophoresis (FACE). The abundance of aggrecan, versican, and specific aggrecanase‐generated products was determined by Western analysis. Joint changes were similar for WT mice taken through either the DMM or the TTR model. ADAMTS5 ablation essentially eliminated cartilage erosion and fibrous overgrowth in both models. In the TTR model, ADAMTS5 ablation did not eliminate aggrecanase activity from the articular cartilage but blocked fibrosis and resulted in the accumulation of aggrecan in the articular cartilage. The cartilage protection provided by ADAMTS5 ablation in the mouse does not result from prevention of aggrecanase activity per se, but it appears to be due to a blockade of joint tissue fibrosis and a concomitant increase in cartilage aggrecan content. © 2010 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 29:516–522, 2011
Where is the distal fracture line location of dorsally displaced distal radius fractures?
Authors: Baumbach Sebastian Felix , Schmidt Reinhard , Varga Peter , Heinz Thomas , Vécsei Vilmos , Zysset Philippe K. 
Published: October 2010

AbstractNo consensus currently exists on the facture location of dorsally displaced distal radius fractures (DRFs). We present a systematic evaluation of the distal fracture line (DFL) location of DRFs and possible influencing factors. Determining the average location of DRFs provides a basis for developing more sensitive tests to determine bone strength using a variety of imaging techniques and for developing improved biomechanical models to test fracture characteristics and surgical implants. Initial radiographs of 157 DRFs dorsally displaced DRFs in patients aged 40–74 years were identified, patient and trauma specific data were collected, and standard radiographic measurements and (AO) fracture classification were performed. The dorsal and palmar DFL locations relative to the corresponding apex of the lunate facet were measured. The DFL was located dorsally 7.9 ± 2.7 mm and palmarly 11.7 ± 3.9 mm proximal to the corresponding lunate fossa apex. The dorsal DFL was significantly distal to the palmar one (p < 0.001), but the two did not correlate (r2 = 0.018, p = 0.095). DFL location was independent of age, energy of the fall, and fracture complexity. © 2010 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 29:489–494, 2011
Comparative study of the cationic surfactants and their influence on the alkaline hydrolysis of acetylsalicylic acid
Authors: Kumar Birendra , Ghosh Kallol K. , Dafonte P. Rodriquez 
Published: October 2010

AbstractA kinetic study of the reaction of acetylsalicylic acid (aspirin) with sodium hydroxide has been studied in the presence of some conventional and novel cationic surfactants. The pseudo‐first‐order rate constant increases with the surfactant concentration initially and then decreases. In comparison to conventional cationic surfactants, i.e., cetyltrimethylammonium bromide and cetylpyridinium bromide, novel alkyldiethylethanolammonium bromide (R = C16) surfactant accelerated the alkaline hydrolysis significantly. The pseudophase ion‐exchange model has been applied to fit the experimental results. Activation parameters have also been evaluated. © 2010 Wiley Periodicals, Inc. Int J Chem Kinet 43: 1–8, 2011
Treatment of fibrous dysplasia of the proximal femur by means of pedicled iliac crest bone graft: A case report
Authors: Perea‐Tortosa D. , García‐López A. , Saura‐Sánchez E. , Aguirre‐Pastor A. 
Published: October 2010

AbstractIn this report, we present a case of treatment of fibrous dysplasia (FD) of the proximal femur with the pedicled iliac crest bone graft. An 18‐year‐old patient presented with hip pain and polyostotic dysplasia with involvement of the proximal femur and a history of pathological fracture. The patient was operated on using vascularized bone graft from the iliac crest and osteosynthesis with Dynamic Hip Screw (DHS®). With vascularized bone graft, we found an improvement on X‐ray with no reabsorption, and with osteosynthesis, we controlled the pain and prevented pathological fracture and progression of the deformity. Several other studies where the pedicled iliac crest bone graft has been successfully used for the management of defects in the proximal femur (osteonecrosis of the femoral head and pseudarthrosis of the femoral head) can be found in the medical literature. However, the pedicled iliac crest bone graft in a patient with FD of the proximal femur is unique. © 2010 Wiley‐Liss, Inc. Microsurgery, 2011.
Femoral head osteonecrosis: Why choose free vascularized fibula grafting
Authors: Korompilias Anastasios V. , Beris Alexandros E. , Lykissas Marios G. , Kostas‐Agnantis Ioannis P. , Soucacos Panayiotis N. 
Published: October 2010

AbstractOsteonecrosis of the femoral head is a disease in which bone death occurs and usually progresses to articular incongruity and subsequent osteoarthritis. To delay the process of the disease and the conversion to total hip arthroplasty, many surgical techniques have been described. Core decompression, nonvascularized autologous bone grafts, porous tantalum implant procedure, and various osteotomies have been used for the management of early precollapse stage osteonecrosis of the femoral head. However, none of these procedures is neither entirely effective nor can obtain predictable results. With the progress of microsurgery, the implantation of a free vascularized fibula graft to the necrotic femoral head has provided the most consistently successful results. Although the procedure is technically demanding, there is growing recognition that the use of free vascularized fibula graft may improve patient quality of life by functional improvement and pain alleviation. The success of the procedure is related to decompression of the femoral head, excision of the necrotic bone, and addition of cancellous bone graft with osteoinductive and osteoconductive properties, which augments revascularization and neoosteogenesis of the femoral head. Free vascularized fibula graft, especially in younger patients, is a salvaging procedure of the necrotic femoral head in early precollapse stages. In postcollapse osteonecrosis, the procedure appears to delay the need for total hip arthroplasty in the majority of patients. The purpose of this review article is to update knowledge about treatment strategies in femoral head osteonecrosis and to compare free vascularized fibula grafting to traditional and new treatment modalities. © 2010 Wiley‐Liss, Inc. Microsurgery, 2011.
Multi‐system influences on adolescent risky sexual behavior
Authors: Chen Angela Chia‐Chen , Thompson Elaine Adams , Morrison‐Beedy Dianne 
Published: October 2010

AbstractWe examined multi‐system influences on risky sexual behavior measured by cumulative sexual risk index and number of nonromantic sexual partners among 4,465 single, sexually experienced adolescents. Hierarchical Poisson regression analyses were conducted with Wave I–II data from the National Longitudinal Study of Adolescent Health. Individual and family factors predicted both outcome measures. Neighborhood set predicted cumulative sexual risk index only, and peer factors predicted the number of nonromantic sexual partners only. School set did not predict either outcome. There were significant associations among risky sexual behavior, drug use, and delinquent behaviors. The results highlight the need for multifaceted prevention programs that address relevant factors related to family, peer and neighborhood influence as well as individual factors among sexually active adolescents. © 2010 Wiley Periodicals, Inc. Res Nurs Health 33:512–527, 2010
Familial pleuropulmonary blastoma in Australia
Authors: Cross Siobhan F. , Arbuckle Susan , Priest John R. , Marshall Glenn , Charles Adrian , Pozza Luciano Dalla 
Published: October 2010

AbstractWe present three cases of pleuropulmonary blastoma (PPB) in Australian children. Each had a family history of childhood tumors which collectively included PPB, infant lung cyst, cystic nephroma, medullo‐epithelioma and a Sertoli–Leydig ovarian tumor. Two of the patients also had additional malignancies: a concurrent bladder rhabdomyosarcoma and a post therapy non‐PPB malignant lung tumor. In two cases, the family histories were elicited years after the PPB diagnosis. Archived pathology material allowed revision of pathologic diagnoses from decades earlier. These cases illustrate the importance of detailed inquiry into family medical history and the pleiotropy of the PPB‐related familial cancer predisposition syndrome, which appears to result from heterozygous DICER1 mutations. Pediatr Blood Cancer. 2010;55:1417–1419. © 2010 Wiley‐Liss, Inc.