bluuebunny/crossref_metadata_2025_split huggingface dataset:
Le deuil infini des maternités sans objet
Authors: Bydlowski Monique 
Published: January 2012

Les femmes ayant traversé la perte d’une grossesse proche de son terme développent un syndrome mélancolique sans tendance spontanée à l’évolution vers un deuil naturel. Cet état morbide tardif est habituellement sous-estimé. Il est remarquable par l’importance de la fixation à l’événement causal, par les cauchemars et la fréquence des phénomènes d’hallucinations positives (foetus fantôme) et négatives (non perception du foetus de la grossesse suivante). Ces situations clinique tardives sont analogues, quelles que soient les circonstances de la mort foetale : Interruption Médicale ou thérapeutique de Grossesse (IMG), Mort Foetale In Utero (MFIU) ou Infanticide criminel.
IL-21 Receptor Is Required for the Systemic Accumulation of Activated B and T Lymphocytes in MRL/MpJ-Faslpr/lpr/J Mice
Authors: Rankin Andrew L. , Guay Heath , Herber Deborah , Bertino Sarah A. , Duzanski Tatyana A. , Carrier Yijun , Keegan Sean , Senices Mayra , Stedman Nancy , Ryan Mark , Bloom Laird , Medley Quintus , Collins Mary , Nickerson-Nutter Cheryl , Craft Joe , Young Deborah , Dunussi-Joannopoulos Kyri 
Published: January 2012

AbstractMRL/MpJ-Faslpr/lpr/J (MRLlpr) mice develop lupus-like disease manifestations in an IL-21–dependent manner. IL-21 is a pleiotropic cytokine that can influence the activation, differentiation, and expansion of B and T cell effector subsets. Notably, autoreactive CD4+ T and B cells spontaneously accumulate in MRLlpr mice and mediate disease pathogenesis. We sought to identify the particular lymphocyte effector subsets regulated by IL-21 in the context of systemic autoimmunity and, thus, generated MRLlpr mice deficient in IL-21R (MRLlpr.IL-21R−/−). Lymphadenopathy and splenomegaly, which are characteristic traits of the MRLlpr model were significantly reduced in the absence of IL-21R, suggesting that immune activation was likewise decreased. Indeed, spontaneous germinal center formation and plasma cell accumulation were absent in IL-21R–deficient MRLlpr mice. Correspondingly, we observed a significant reduction in autoantibody titers. Activated CD4+ CD44+ CD62Llo T cells also failed to accumulate, and CD4+ Th cell differentiation was impaired, as evidenced by a significant reduction in CD4+ T cells that produced the pronephritogenic cytokine IFN-γ. T extrafollicular helper cells are a recently described subset of activated CD4+ T cells that function as the primary inducers of autoantibody production in MRLlpr mice. Importantly, we demonstrated that T extrafollicular helper cells are dependent on IL-21R for their generation. Together, our data highlighted the novel observation that IL-21 is a critical regulator of multiple pathogenic B and T cell effector subsets in MRLlpr mice.
Creating a Living Hyaline Cartilage Graft Free from Non‐Cartilaginous Constituents: An Intermediate Role of a Biomaterial Scaffold
Authors: Su Kai , Lau Ting Ting , Leong Wenyan , Gong Yihong , Wang Dong‐An 
Published: January 2012

AbstractA novel living hyaline cartilage graft (LhCG) with controllable dimensions and free of non‐cartilaginous constituents for articular regeneration is developed. As a living graft for regenerative medicine, LhCG is purely living tissue based and truly scaffold‐free. The process of neotissue formation in LhCG is mediated by an interim biomaterial‐based novel scaffolding system. This design highlights a philosophy of using biomaterials in engineered regenerative medicine as a transient guiding facility rather than a permanent part of substitute. The fabrication is designed and practiced in a continuous and integrated process, which attributes to its simplicity in operation. Because of the intrinsic non‐cell‐adhesive property of hydrogel scaffolds, articular chondrocytes’ phenotype is always preserved throughout the whole procedure, which has been tested and approved both in vitro and in vivo. In situ grafting trials in a rabbit model showcase high success rates in both cartilage repair and graft‐host integration. Beyond cartilage repair, this LhCG model may provide a living‐tissue‐based open platform or niche for multi‐tissue regenerations.
Guilt as a Consequence of Migration
Authors: Ward Catherine , Styles Irene 
Published: January 2012

ABSTRACTMigration, for some individuals, can be a highly emotional experience. Guilt expressed by daughters, as a result of leaving parents and family following migration, necessitates exploration but has been largely neglected in migrant research. This study involved migrant women from the United Kingdom (UK) to Australia. A cross‐sectional design in a naturalistic setting was used which involved both quantitative (questionnaire) and qualitative approaches. In total 154 participants completed a questionnaire; however it is the responses of a subset of 40 women who were interviewed which are reported here. Bowlby's (1969) mother–infant attachment theory provided the theoretical framework for this investigation. Bowlby outlined the reaction to loss of attachment in four stages: it is in Stage 2 (yearning and pining) that feelings of guilt manifest. Miceli and Castelfranchi's (1998) three component model of guilt was used to explore the construct of guilt which can be associated with one's behavior, with responsibility for one's actions, and with the consequences of that action.Findings indicated that feelings of guilt, for some of these migrant participants, were intense and long lasting. Guilt resulted from, firstly, leaving parents in the homeland, secondly, being the only daughter or the only child and leaving parents in the homeland, and thirdly, making the attachment between grandparents and grandchildren vulnerable as a consequence of migration. Results from the study shows that guilt is a powerful emotion that impacts on the well‐being of migrant women and, through them, on their families. The results also indicate that guilt, on the part of both men and women deserves more in‐depth inquiry to detail the psychological impact on migrants. Copyright © 2012 John Wiley & Sons, Ltd.
Impact of participation in randomized trials on outcome following surgery for gastro-oesophageal reflux
Authors: Engström C , Jamieson G G , Devitt P G , Irvine T , Watson D I 
Published: January 2012

Abstract

Background
Patients may be unwilling to participate in clinical trials if they perceive risks. Outcomes were evaluated following surgery for gastro-oesophageal reflux in patients recruited to randomized trials compared with patients not in trials.

Methods
This study compared outcomes of patients who had surgery for reflux within or outside randomized trials between 1994 and 2009. The choice of procedure outside each trial was according to surgeon or patient preference. Clinical outcomes were determined 1 and 5 years after surgery using a standardized questionnaire, with analogue scales to assess heartburn, dysphagia and overall satisfaction. Subgroup analysis was undertaken for those aged less than 75 years undergoing laparoscopic Nissen fundoplication.

Results
Some 417 patients entered six randomized trials evaluating surgery for reflux and 981 underwent surgery outside the trials. The trial group contained a higher proportion of men and younger patients, and patients in trials were more likely to have undergone Nissen fundoplication. At 1 year, patients in the trials had slightly lower heartburn scores and less abdominal bloating, but otherwise similar outcomes to those not in the trials. At 5 years there were no differences, except for a slightly higher dysphagia score for liquids in the trial group. For the subgroup analysis, demographic data were similar for both groups. There were no differences at 1 year, but at 5 years patients enrolled in the trials had higher scores for dysphagia for liquids and heartburn. All of the statistically significant differences were thought unlikely to be clinically relevant.

Conclusion
Participation in a randomized trial assessing surgery for reflux did not influence outcomes.
Outcomes of primary percutaneous coronary intervention for acute myocardial infarction with unprotected left main coronary artery occlusion
Authors: Izumikawa Takuya , Sakamoto Shingo , Takeshita Satoshi , Takahashi Akihiko , Saito Shigeru 
Published: January 2012

AbstractBackground: We determined the in‐hospital and the long‐term outcomes of primary percutaneous coronary intervention (PCI) for acute left main coronary artery (LMCA) occlusion. Methods: Between 1988 and 2009, 72 patients with acute myocardial infarction (AMI) underwent primary PCI for unprotected LMCA occlusion. The short‐ and the long‐term outcomes of primary PCI in these patients were retrospectively evaluated. Results: Upon arrival, cardiogenic shock was observed in 33 (46%) patients and cardiopulmonary arrest (CPA) in 12 (17%). Twenty‐three (32%) required extracorporeal life support and 64 (89%) intra‐aortic balloon pumping. Although successful reperfusion was achieved in 60 (83%) patients, in‐hospital death was observed in 32 (44%). Multivariate analysis revealed predictors of in‐hospital death to be CPA on arrival (RR, 7.05; 95% CI: 1.28–39.0; P = 0.025). During 1.7 ± 2.9 years of follow‐up, 10 of the 40 hospital survivors died. All presenting CPA on arrival died within 2 years. Although the estimated survival of the all study patients was only 26.2% at 8 years by the Kaplan–Meier methods, those without shock/CPA on arrival showed nearly flat survival curve after 4 years. Conclusions: Despite performance of primary PCI, patients with AMI due to LMCA occlusion were associated with >50% in‐hospital mortality. Hemodynamic deficit upon arrival was the major determinant of their poor hospital outcomes. The hospital survivors, however, were associated with favorable long‐term outcomes. © 2012 Wiley Periodicals, Inc.
Monoesterase Activity of a Purple Acid Phosphatase Mimic with a Cyclam Platform
Authors: Comba Peter , Gahan Lawrence R. , Hanson Graeme R. , Mereacre Valeriu , Noble Christopher J. , Powell Annie K. , Prisecaru Ion , Schenk Gerhard , Zajaczkowski‐Fischer Marta 
Published: January 2012

AbstractThe synthesis and characterization of a novel dinucleating ligand L (L=4,11‐dimethyl‐1,8‐bis{2‐[N‐(di‐2‐pyridylmethyl)amino]ethyl}cyclam) and its μ‐oxo‐bridged diferric complex [(H2L){FeIII2(O)}(Cl)4]2+ are reported. This diiron(III) complex is the first example of a truly functional purple acid phosphatase (PAP) mimic as it accelerates the hydrolysis of the activated phosphomonoester 2,4‐dinitrophenyl phosphate (DNPP). The spectroscopic and kinetic data indicate that only substrates that are monodentately bound to one of the two ferric ions can be attacked by a suitable nucleophile. This is, most probably, a terminal iron(III)‐bound hydroxide. DFT calculations support this assumption and also highlight the importance of secondary interactions, exerted by the protonated cyclam platform, for the positioning and activation of the iron(III)‐bound substrate. Similar effects are postulated in the native enzyme but addressed in PAP mimics for the first time.
Monitoring and Prediction of the Degradation of Insulating Materials in Thermal Processing Equipments
Authors: Kreutzmann Dominik , Möntmann Dirk , Pohland vom Schloß Heide , Lucka Klaus , Teneva‐Kosseva Guergana , Uhlig Volker , Trimis Dimosthenis 
Published: January 2012

AbstractDie vorliegende Forschungsarbeit beschäftigt sich mit der Detektion von Schädigungen an Wandzustellungen von Thermoprozessanlagen im laufenden Betrieb. Dabei wird eine Temperaturerhöhung als Hinweis auf eine Dämmungsschädigung genutzt. Im Laufe der Untersuchungen wurde deutlich, dass eine Temperaturmessung in der Dämmung die Vorhersage der Schädigung wesentlich verbessert. Durch numerische Simulation wurde gezeigt, dass aus der Wandtemperaturverteilung auf die Tiefe einer Schädigung geschlossen werden kann.
Curvelet processing of MRI for local image enhancement
Authors: Tsai Kunyu , Ma Jianwei , Ye Datian , Wu Jian 
Published: January 2012

SUMMARYMagnetic resonance imaging provides very good contrast between different soft tissues; however, in some cases, this technique is not so suitable to image calcified structures like bones. The quality of images is often degraded by blur edges or noises, which makes it difficult to accurately identify bone structures. In this paper, we proposed a new curvelet preprocessing method for local image enhancement to especially improve the quality of spinal MRI. Our objective is to both sharpen boundaries and smoothen the intensity variation of the vertebra. In the first phase, we extract features through curvelet coefficients and the gradient of the original image, then we utilize fuzzy cluster method to classify the whole image scope into the ‘edge’ region and the ‘nonedge’ region. In the second phase, we locally sharpen or smoothen the image by adaptive adjustment of curvelet coefficients and Gaussian smoothing method in different subregions. To evaluate the effect of the preprocessing method, we examine the gradient of the image and its segmentation results as the assessments. The experiment results show that the feature extraction method is effective for classification and the vertebra performs higher contrast on boundaries and less noises after the enhancement, which indeed helps increase the accuracy of further segmentation. Copyright © 2012 John Wiley & Sons, Ltd.
Adaptive resource allocation for multicast orthogonal frequency division multiple access systems with guaranteed BER and rate
Authors: Bai Lin , Chen Chen , Wu Bo , He Jianhua 
Published: January 2012

SUMMARYIn this paper, we propose a resource allocation scheme to minimize transmit power for multicast orthogonal frequency division multiple access systems. The proposed scheme allows users to have different symbol error rate (SER) across subcarriers and guarantees an average bit error rate and transmission rate for all users. We first provide an algorithm to determine the optimal bits and target SER on subcarriers. Because the worst‐case complexity of the optimal algorithm is exponential, we further propose a suboptimal algorithm that separately assigns bit and adjusts SER with a lower complexity. Numerical results show that the proposed algorithm can effectively improve the performance of multicast orthogonal frequency division multiple access systems and that the performance of the suboptimal algorithm is close to that of the optimal one. Copyright © 2012 John Wiley & Sons, Ltd.
Chemical Exchange Saturation Transfer Is Unaffected by Modest Changes in Pressure
Authors: Webber Benjamin C. , Carney Christiane E. , Woods Mark 
Published: January 2012

AbstractParaCEST (Paramagnetic Chemical Exchange Saturation Transfer) agents offer an unparalleled opportunity to perform quantitative molecular imaging by MRI. Agents that can alter the image contrast they generate in response to changes in local environmental parameters such as pH, glucose concentration, or lactate concentration can be used ratiometrically to quantitatively describe the local tissue environment. However, when performing such quantitative measurements it is important that the results are not confounded by changes in a second environmental parameter. Pressure in vivo is far from uniform, varying both through the respiratory cycle and from tissue to tissue (tumors, in particular, have high interstitial pressures). Since paraCEST agents have positive activation volumes, their exchange kinetics and therefore the CEST effect that they generate are necessarily related to pressure. The purpose of this investigation was to examine whether the relatively small changes in pressure exhibited in vivo could affect CEST sufficiently to confound attempts to quantify other local environmental parameters. The CEST properties of a rigid EuDOTA‐tetraamide was examined at temperatures ranging from 288 to 319 K, at applied pressures ranging from 0 to 414 kPa, and presaturation (B1) powers ranging from 524 to 935 Hz. At no point was pressure found to affect the CEST generated by this chelate, which indicates that changes in in vivo pressure is unlikely to confound the quantitative measurement of physiologically relevant parameters by paraCEST MRI.
Regioselective Photochemical Rearrangement of N‐Mesyloxylactams
Authors: Pichette Simon , Aubert‐Nicol Samuel , Lessard Jean , Spino Claude 
Published: January 2012

AbstractN‐Mesyloxylactams can undergo ring contraction either by C‐3 (usually observed) or C‐5 migration. C‐5 migration can occur when the C‐3 migration product possesses ring strain, but it does not usually compete with C‐3 migration. The greater preference for C‐3 migration is due to the carbonyl oxygen atom, which greatly stabilizes the intermediate.
A Phosphane‐Mediated Diastereoselective, Domino aza‐Morita–Baylis–Hillman/Reduction Sequence Involving Water as Hydrogen Source
Authors: Duvvuru Deepti , Retailleau Pascal , Betzer Jean‐François , Marinetti Angela 
Published: January 2012

AbstractThe new domino process disclosed here involves PBu3 as both a nucleophilic and a reducing agent. The process combines suitable electron‐poor dienes, N‐tosylimines, tri‐n‐butylphosphane and water. The final products formally result from reduction of vinylogous aza‐Morita–Baylis–Hillman adducts. The reaction proceeds with an excellent stereochemical control of the relative configurations of the newly created contiguous carbon centres.
Proteomics analysis of in vitro protein methylation during Src‐induced transformation
Authors: Chiou Yi‐Ying , Fu Shu‐Ling , Lin Wey‐Jinq , Lin Chao‐Hsiung 
Published: January 2012

AbstractSrc, a nonreceptor tyrosine kinase, was the first oncogene identified from an oncogenic virus. Mechanistic studies of Src‐induced transformations aid in understanding the pathologic processes underlying tumorigenesis and may provide new strategies for cancer therapy. Although several pathways and protein modifications are reportedly involved in Src‐induced transformation, the detailed mechanisms of their regulation remain unclear. Protein methylation is an important PTM that is widely involved in cellular physiology. In this study, we determined if protein methylation was involved in Src activation and which methylated proteins were associated with this activity. Using in vitro methylation and 2‐DE analysis of viral Src (v‐Src)‐transformed rat kidney epithelial cells (RK3E), several known and novel methylated proteins were identified based on their changes in methylation signal intensity upon transformation. Among these, elongation factor 2 (EF‐2), heterogeneous nuclear ribonucleoprotein K (hnRNP K), and β‐tubulin protein expressions remained unchanged, indicating that their altered methylation levels were due to Src activation. In addition, the altered expression of β‐actin, vimentin, and protein phosphatase 2, catalytic subunit (PPP2C) as well as protein phosphatase 2, catalytic subunit methylation were also confirmed in RK3E cells transformed with a human oncogenic Src mutant (Src531), supporting their association with Src‐induced transformation in human cancer. Together, we showed putative involvement of protein methylation in Src activation and our identification of methylated proteins provides important targets for extensively studying Src‐induced transformations.
Modeling of droplet traffic in interconnected microfluidic ladder devices
Authors: Song Kui , Zhang Li , Hu Guoqing 
Published: January 2012

AbstractThe problem of controlling the droplet motion in multiphase flows on the microscale has gained increasing attention because the droplet‐based microfluidic devices provide great potentials for chemical and biological applications. It is critical to understand the relevant physics on droplet hydrodynamics and thus control the generation, motion, splitting, and coalescence of droplets in complex microfluidic networks. Numerical simulations using the volume of fluid algorithm are conducted to investigate the time‐dependent dynamics of droplets in gas–liquid multiphase devices. An analytical model based on the electronic–hydraulic analogy is developed to describe the hydrodynamic behavior of the droplets in interconnected microfluidic ladder devices. It is found that the pressure drop caused by the droplets plays a critical role in the droplet synchronization. A fitted formula for pressure drops in the presence of surfactant is achieved by using numerical simulations. Both the numerical and the theoretical results agree well with the corresponding experimental results.
Optimal distributed interference avoidance: potential game and learning
Authors: Wang Jinlong , Xu Yuhua , Anpalagan Alagan , Wu Qihui , Gao Zhan 
Published: January 2012

ABSTRACTThis article studies the problem of distributed interference avoidance (IA) through channel selection for distributed wireless networks, where mutual interference only occurs among nearby users. First, an interference graph is used to characterise the limited range of interference, and then the distributed IA problem is formulated as a graph colouring problem. Because solving the graph colouring problem is non‐deterministic polynomial hard even in a centralised manner, the task of obtaining the optimal channel selection profile distributively is challenging. We formulate this problem as a channel selection game, which is proved to be an exact potential game with the weighted aggregate interference serving as the potential function. On the basis of this, a distributed learning algorithm is proposed to achieve the optimal channel selection profile that constitutes an optimal Nash equilibrium point of the channel selection game. The proposed learning algorithm is fully distributed because it needs information about neither the network topology nor the actions and the experienced interference of others. Simulation results show that the proposed potential game theoretic IA algorithm outperforms the existing algorithm because it minimises the aggregate weighted interference and achieves higher network rate. Copyright © 2012 John Wiley & Sons, Ltd.
Analysis of ethyl glucuronide in hair samples by liquid chromatography‐electrospray ionization–tandem mass spectrometry (LC‐ESI‐MS/MS)
Authors: Cabarcos Pamela , Hassan Huda M. , Tabernero María Jesús , Scott Karen S. 
Published: January 2012

ABSTRACTMany different biomarkers can be used to evaluate ethanol intake. Ethyl glucuronide (EtG) is a direct phase II and minor metabolite of ethanol formed through the UDP‐glucuronosyl transferase‐catalyzed conjugation of ethanol with glucuronic acid. Its investigation is of interest in both clinical and forensic contexts because of the wide window of detection. A sensitive LC‐MS/MS procedure has been developed and fully validated according to the guidelines of forensic toxicology for the analysis of EtG in hair. Sample preparation and chromatographic separation were thoroughly optimized. The analysis was performed in the multiple reaction monitoring mode using the transitions m/z 221 → 203 (for the quantification) and 221 → 85 or 75 (for the qualification) for EtG, and m/z 226 → 208 (for quantification) and 226 → 75 or 85 (for qualification) for EtG‐D5, used as the internal standard. Analyses were carried out using an Inertsil ODS‐3 column (100 × 3 mm i.d., 3 µm particle size) and a mobile phase composed of formic acid and acetonitrile. Various SPE cartridges and solvents were tested in order to obtain the highest recoveries and cleanest extracts. The assay linearity of EtG was confirmed over the range from 20 to 2500 pg mg−1, with a coefficient of determination (R2) above 0.99. The lower limit of quantitation (LLOQ) was 20 pg mg−1 and the limit of detection was 10 pg mg−1. Intra‐ and inter‐day assays were less than 15% except at the LLOQ (20%). The analytical method was applied to 72 post‐mortem hair samples. EtG concentration in the hair ranged from 0 to 653 pg mg−1 hair. Copyright © 2012 John Wiley & Sons, Ltd.