bluuebunny/crossref_metadata_2025_split huggingface dataset:
RIFINs displayed on malaria-infected erythrocytes bind both KIR2DL1 and KIR2DS1
Authors: Sakoguchi Akihito , Chamberlain Samuel G. , Mørch Alexander M. , Harrison Thomas E. , Dustin Michael L. , Arase Hisashi , Higgins Matthew K. , Iwanaga Shiroh 
Published: April 2024

AbstractTo discriminate between our own cells and foreign cells such as a pathogen, natural killer cells are armed with inhibitory and activating immune receptors. In some cases, such as the KIRs, these are found in pairs, with inhibitory and activating receptors containing nearly identical extracellular domains that are coupled to different intracellular signalling domains1. The balance in signalling mediated by these receptors determines whether an NK cell is activated to destroy a target cell. Previous studies have shown that RIFINs, displayed on surfaces ofPlasmodium falciparum-infected erythrocytes, can bind to inhibitory immune receptors and dampen NK cell activation2,3, reducing parasite killing. Here, we identify a clade of RIFINs that bind to inhibitory immune receptor KIR2DL1 approximately ten-times more strongly than KIR2DL1 binds its host ligand, MHC class I. We show that this interaction mediates inhibitory signalling and reduces activation of KIR2DL1-expressing NK cells. We reveal the structural basis for KIR2DL1 binding and show that the RIFIN binding surface of KIR2DL1 is conserved in the activating immune receptor KIR2DS1. We find that KIR2DL1-binding RIFINs can also bind to KIR2DS1 and that these RIFINs cause activation of KIR2DS1-expressing NK cells. This highlights the evolutionary battle between pathogen and host, suggesting that activating KIRs may have evolved to allow detection of red blood cells infected withPlasmodium falciparum, helping the host to clear the parasite.
Manipulating TDP43 Aggregation via RNA G-quadruplexes
Authors: Oldani Emily G. , Reynolds Caicedo Kevin M. , Spaeth Herda McKenna E. , Sachs Adam H. , Chapman Erich G. , Kumar Sunil , Linseman Daniel A. , Horowitz Scott 
Published: April 2024

ABSTRACTThe events that lead to protein misfolding diseases are poorly understood. Many proteins implicated in neurodegenerative diseases (e.g., TDP43) interact with nucleic acids, including RNA G-quadruplexes. In this work, we investigate whether RNA G-quadruplexes play a role in TDP43 aggregation in biophysical and cellular models. We find that G-quadruplexes modulate TDP43 aggregation in a biophysical model and in multiple cell types, including yeast, HEK293T, and motor-neuron-like NSC-34 cells. In yeast cells, treatment with G-quadruplexes causes increased TDP43 accumulation in cells before cellular death. In HEK293T cells expressing TDP43, incubation with G-quadruplex-binding small molecules induces a reduction in chemically-induced TDP43 aggregation. Finally, in NSC-34 cells overexpressing TDP43, we show that G-quadruplexes co-localize with TDP43 aggregates under stress conditions and treatment with G-quadruplex-binding small molecules decreases TDP43-mediated toxicity. Together, these findings suggest that a novel approach to treating protein misfolding diseases may be to target specific RNA structures such as G-quadruplexes.
Assessing the implications of BIM on sustainability of construction projects through design risk management
Authors: Gaur Sulakshya , Tawalare Abhay 
Published: April 2024

PurposeDesign cost overrun is one of the prominent factor that can impact the sustainable delivery of the project. It can be encountered due to a lack of information flow, design variation, etc. thereby impacting the project budget, waste generation and schedule. An overarching impact of this is witnessed in the sustainability dimensions of the project, mainly in terms of economic and environmental aspects. This work, therefore, aims to assess the implications of a technological process, in the form of building information modelling (BIM), that can smoothen the design process and mitigate the risks, thus impacting the sustainability of the project holistically.Design/methodology/approachThe identified design risks in construction projects from the literature were initially analysed using a fuzzy inference system (FIS). This was followed by the focus group discussion with the project experts to understand the role of BIM in mitigating the project risks and, in turn, fulfilling the sustainability dimensions.FindingsThe FIS-based risk assessment found seven risks under the intolerable category for which the BIM functionalities associated with the common data environment (CDE), data storage and exchange and improved project visualization were studied as mitigation approaches. The obtained benefits were then subsequently corroborated with the achievement of three sustainability dimensions.Research limitations/implicationsThe conducted study strengthens the argument for the adoption of technological tools in the construction industry as they can serve multifaceted advantages. This has been shown through the use of BIM in risk mitigation, which inherently impacts project sustainability holistically.Originality/valueThe impact of BIM on all three dimensions of sustainability, i.e. social, economic and environmental, through its use in the mitigation of critical risks was one of the important findings. It presented a different picture as opposed to other studies that have mainly been dominated by the use of BIM to achieve environmental sustainability.
Financial constraints, corporate tax avoidance and environmental, social and governance performance
Authors: Mohamad Ariff Akmalia , Kamarudin Khairul Anuar , Musa Abdullahi Zaharadeen , Mohamad Noor Afzalina 
Published: April 2024

Purpose
This paper aims to investigate the relationship between corporate tax avoidance and environmental, social and governance (ESG) performance and the moderating effect of financial constraints on the relationship between corporate tax avoidance and ESG performance.

Design/methodology/approach
The sample consists of a global data set involving 24,259 firm-year observations from 49 countries for the years 2011–2020. Corporate ESG performance was extracted from the Thomson Reuters database. The book-tax difference model was used for measuring corporate tax avoidance, while financially constrained firms were identified using the Kaplan and Zingales (1997) index.

Findings
The results show that firms with higher tax avoidance are associated with higher ESG performance, but lower ESG performance is shown for firms with higher financial constraints. The results further indicate that the positive impact of corporate tax avoidance on ESG performance becomes weaker for firms with higher financial constraints.

Practical implications
The findings imply that policymakers and regulators should focus on mechanisms to promote more internal funds to assist firms in pursuing ESG-related initiatives, such as through tax incentives. Investors should understand the “smokescreen” effect of corporate tax avoidance on ESG performance, especially for firms with financial constraints.

Originality/value
This analysis provides international evidence on the link between tax avoidance and ESG and considers the joint effect of pressures for internal funds, through tax and financing constraints, on corporate ESG performance.
Unveiling connections between organizational dimensions, employee performance and boundary-spanning behaviors: a study on perceived organizational support and perceived supervisory support
Authors: Wang Jiaxin (Sylvia) , Fu Xiaoxiao 
Published: April 2024

Purpose
This study aims to examine the influence of perceived organizational support (POS) on boundary-spanning behaviors (BSBs) among frontline employees in the hospitality industry. It also considered perceived supervisory support (PSS) as a moderating factor within a conceptual model.

Design/methodology/approach
Data were gathered from 651 full-time hospitality employees across 12 hotels in China. The analysis of the data used confirmatory factor analysis and structural equation modeling.

Findings
The findings revealed that POS influences hospitality boundary spanners’ BSBs, specifically external representation (ER), internal influence (II) and service delivery (SD). In addition, PSS moderates the relationship between POS and these frontline employees’ behaviors.

Practical implications
This study offers practical strategies for hospitality professionals to enhance frontline employees’ BSBs and foster supportive workplaces that drive employee excellence. These strategies encompass cultivating a supportive organizational culture, implementing supportive measures, fostering a sense of belonging among employees and ensuring supervisors’ well-being and competence in supporting their teams during daily interactions. These actions effectively motivate customer-contact employees to excel in their performance.

Originality/value
Fostering a helpful attitude in frontline employees is crucial for service firms’ success. Hospitality organizations must provide support to achieve this. Few studies have explored how organizational support contributes positively to the BSBs of customer-contact employees. This study goes beyond oversimplification and delves into the nuanced interplay between perceived support (POS and PSS) and hospitality frontline employees’ BSBs, focusing on ER, II and SD. The moderated mediating model enhances the understanding of support dynamics in the organizational context.
Face-to-face, online or HyFlex instruction? The effects of self-directed learning on stress reduction and student satisfaction among emerging adults
Authors: Choi Soochan , Li Zhen , Boonme Kittipong , Ren He 
Published: April 2024

Purpose
The outbreak of COVID-19 significantly disrupted educational activities and forced universities to rapidly transition from the traditional face-to-face (F2F) environment to online learning formats. The purpose of this paper is to examine the effects of self-directed learning (SDL) on three instructional modalities (F2F, online and HyFlex) among emerging adults. The authors propose that class interaction enjoyment serves as a channel to understand how SDL relates to students’ satisfaction and stress reduction.

Design/methodology/approach
An online survey was distributed to the emerging adults, aged 18–25, at six universities across five different US states. Construct validity and reliability were tested by using confirmatory factor analysis. The moderated mediation relationship was examined by calculating the indirect effects of each course delivery format.

Findings
The results show that the positive indirect effect of SDL on stress reduction via interaction enjoyment was stronger for F2F classes. In addition, the positive indirect effect of SDL on class satisfaction via interaction enjoyment was stronger for HyFlex classes.

Originality/value
This literature has shown contradictory results: the effects of SDL on student satisfaction and stress reduction prove to be sometimes positive, sometimes non-significant. To better understand this relationship, the authors aim at a mediating variable – enjoyment of class interaction – as a mechanism, and a moderating variable – the instructional modality – as a boundary condition. This research contributes to emerging adults learning literature by involving the interplay among SDL, enjoyment of class interaction and the instructional modality.
Metaverse decline, growth in online videos increases: implications to libraries
Authors: Oladokun Bolaji David , Durodolu Oluwole Olumide , Tella Adeyinka , Ajani Yusuf Ayodeji , Owolabi Abayomi Kehinde 
Published: April 2024

Purpose
This paper aims to explore the decline of the metaverse and the concurrent growth of online videos, examining their implications for libraries. It analyzes factors contributing to the metaverse decline, such as technical issues and privacy concerns, and explores the emergence and popularity of online video platforms.

Design/methodology/approach
This study applied the interpretive content/document analysis of literature harvested from different databases of Scopus, Web of Science and Directory of Open Access Journals. Given the shift in digital consumption patterns and their impact on libraries, the paper systematically reviews the literature to elucidate the changing landscape of digital engagement and its implications for library services and outreach efforts.

Findings
The paper identifies technical issues, privacy concerns and a lack of interoperability as key factors contributing to the decline of the metaverse. Conversely, the growth of online videos is driven by the emergence of platforms, increasing accessibility to high-speed internet and a diversification of content offerings. These trends reshape user preferences and behaviors, presenting both challenges and opportunities for libraries.

Originality/value
The decline of the metaverse and the rise of online videos underscore the importance of adaptation and innovation for libraries. To remain relevant in the digital age, libraries must transform their services to meet the demand for on-demand content and multimedia resources. The findings highlight the need for libraries to invest in digital literacy and media literacy programs, embrace emerging technologies and forge strategic partnerships with online video platforms. By adapting to changing trends and user preferences, libraries will continue to fulfill their mission of providing access to information and knowledge in the digital age.
Investigating users' discontinuous usage intention toward social networking sites: the roles of motivation and affectivity
Authors: Dang-Van Thac , Thinh Truong Vu , Nguyen Phuoc-Thien , Ming Wong Wong , Nguyen Ninh 
Published: April 2024

PurposeThis study is based on the regulatory focus theory and conservation of resources theory to examine how information confusion leads to users’ discontinuous usage intention of social networking sites (SNSs), with the mediating mechanisms of users’ motivation and affectivity.Design/methodology/approachData were obtained from 270 users in different SNSs in Vietnam. Structural equation modeling was used to analyze the sample data and test the hypotheses.FindingsResults show that information confusion has a positive influence on discontinuous usage intention, and prevention focus positively mediates this relationship. Furthermore, the negative affectivity positively mediates the link between information confusion and discontinuous usage intention and that between prevention focus and discontinuous usage intention. In addition, prevention focus and negative affectivity together play a serial mediating effect in the link between information confusion and discontinuous usage intention.Originality/valueThis study extends the regulatory focus theory and conservation of resources theory to validate a model that explains the transitional process of users’ motivation and affectivity in the link between information confusion and discontinuous usage intention of SNSs. The findings of this study provide implications for academic researchers and business managers of SNSs to understand and make better decisions to retain their users.
Mixed convective flow of engine oil-based non-Newtonian tri-hybrid nanofluid across a porous rotating disk
Authors: Paul Ashish , Patgiri Bhagyashri , Sarma Neelav 
Published: April 2024

Purpose
Flow induced by rotating disks is of great practical importance in several engineering applications such as rotating heat exchangers, turbine disks, pumps and many more. The present research has been freshly displayed regarding the implementation of an engine oil-based Casson tri-hybrid nanofluid across a rotating disk in mass and heat transferal developments. The purpose of this study is to contemplate the attributes of the flowing tri-hybrid nanofluid by incorporating porosity effects and magnetization and velocity slip effects, viscous dissipation, radiating flux, temperature slip, chemical reaction and activation energy.

Design/methodology/approach
The articulated fluid flow is described by a set of partial differential equations which are converted into one set of higher-order ordinary differential equations (ODEs) by using convenient conversions. The numerical solution of this transformed set of ODEs has been spearheaded by using the effectual bvp4c scheme.

Findings
The acquired results show that the heat transmission rate for the Casson tri-hybrid nanofluid is intensified by, respectively, 9.54% and 11.93% when compared to the Casson hybrid nanofluid and Casson nanofluid. Also, the mass transmission rate for the Casson tri-hybrid nanofluid is augmented by 1.09% and 2.14%, respectively, when compared to the Casson hybrid nanofluid and Casson nanofluid.

Originality/value
The current investigation presents an educative response on how the flow profiles vary with changes in the inevitable flow parameters. As per authors’ knowledge, no such scrutinization has been carried out previously; therefore, our results are novel and unique.
A hybrid islanding detection method using wavelet transform for hybrid systems with zero non-detection zone
Authors: Mishra Mamun , Pati Bibhuti Bhusan 
Published: April 2024

Purpose
Islanding detection has become a serious concern due to the extensive integration of renewable energy sources. The non-detection zone (NDZ) and system-specific applicability, which are the two major issues with the islanding detection methods, are addressed here. The purpose of this paper is to devise an islanding detection method with zero NDZ and, which will be applicable to all types of renewable energy sources using the sequence components of the point of common coupling voltage.

Design/methodology/approach
Here, a parameter using the sequence components is derived to devise an islanding detection method. The parameter derived from the sequence components of point of common coupling voltage is analysed using wavelet transform. Various operating conditions, such as islanding and non-islanding, are considered for several test systems to evaluate the performance of the proposed method. All the simulations are carried out in Simulink/MATLAB environment.

Findings
The results showed that the proposed method has zero NDZ for both inverter- and synchronous generator-based renewable energy sources. In addition, the proposed method works satisfactorily as per the IEEE 1547 standards requirement.

Originality/value
Performance of the proposed method has been tested in several test systems and is found to be better than some conventional methods.
The false promise of firearms examination validation studies: Lay controls, simplistic comparisons, and the failure to soundly measure misidentification rates
Authors: Gutierrez Richard E. , Prokesch Emily J. 
Published: April 2024

AbstractSeveral studies have recently attempted to estimate practitioner accuracy when comparing fired ammunition. But whether this research has included sufficiently challenging comparisons dependent upon expertise for accurate conclusions regarding source remains largely unexplored in the literature. Control groups of lay people comprise one means of vetting this question, of assessing whether comparison samples were at least challenging enough to distinguish between experts and novices. This article therefore utilizes such a group, specifically 82 attorneys, as a post hoc control and juxtaposes their performance on a comparison set of cartridge case images from one commonly cited study (Duez et al. in J Forensic Sci. 2018;63:1069–1084) with that of the original participant pool of professionals. Despite lacking the kind of formalized training and experience common to the latter, our lay participants displayed an ability, generally, to distinguish between cartridge cases fired by the same versus different guns in the 327 comparisons they performed. And while their accuracy rates lagged substantially behind those of the original participant pool of professionals on same‐source comparisons, their performance on different‐source comparisons was essentially indistinguishable from that of trained examiners. This indicates that although the study we vetted may provide useful information about professional accuracy when performing same‐source comparisons, it has little to offer in terms of measuring examiners' ability to distinguish between cartridge cases fired by different guns. If similar issues pervade other accuracy studies, then there is little reason to rely on the false‐positive rates they have generated.
Mast cell versus basophil activation test in allergy: Current status
Authors: Ebo Didier G. , Bahri Rajia , Tontini Chiara , Van Gasse Athina L. , Mertens Christel , Hagendorens Margo M. , Sabato Vito , Elst Jessy 
Published: April 2024

AbstractIn the past two decades, we witnessed the evolution of the basophil activation test (BAT) from mainly research applications to a potential complementary diagnostic tool to document IgE‐dependent allergies. However, BAT presents some technical weaknesses. Around 10%–15% of tested patients are non‐responders, BAT can be negative immediately post‐reaction and the use of fresh basophils, ideally analysed within 4 h of collection, restricts the number of tests that can be performed per sample. The need for fresh basophils is especially limiting when conducting batch analyses and interlaboratory comparisons to harmonize BAT methodology. These limitations significantly hinder the wider application of BAT and urge the development of alternative testing, such as the mast cell activation test (MAT). The essential difference between BAT and MAT is the heterogeneity of the starting material used to perform the assays. Mast cells are tissue‐resident, so cannot be easily accessed. Current alternative sources for functional studies are generating primary human mast cells, differentiated from donor progenitor cells, or using immortalized mast cell lines. Hence, the methodological approaches for MAT are not only vastly different from BAT, but also different among MAT protocols. This review summarizes the advantages and disadvantages of BAT and MAT assays, dedicating special attention to elucidating the key differences between the cellular sources used and provides an overview of studies hitherto performed comparing BAT and MAT in the diagnosis of IgE‐mediated food and drug allergies.
Sketch Video Synthesis
Authors: Zheng Yudian , Cun Xiaodong , Xia Menghan , Pun Chi‐Man 
Published: April 2024

AbstractUnderstanding semantic intricacies and high‐level concepts is essential in image sketch generation, and this challenge becomes even more formidable when applied to the domain of videos. To address this, we propose a novel optimization‐based framework for sketching videos represented by the frame‐wise Bézier Curves. In detail, we first propose a cross‐frame stroke initialization approach to warm up the location and the width of each curve. Then, we optimize the locations of these curves by utilizing a semantic loss based on CLIP features and a newly designed consistency loss using the self‐decomposed 2D atlas network. Built upon these design elements, the resulting sketch video showcases notable visual abstraction and temporal coherence. Furthermore, by transforming a video into vector lines through the sketching process, our method unlocks applications in sketch‐based video editing and video doodling, enabled through video composition.