bluuebunny/crossref_metadata_2025_split huggingface dataset:
Exact Two-Step Benders Decomposition for the Time Window Assignment Traveling Salesperson Problem
Authors: Çelik Şifa , Martin Layla , Schrotenboer Albert H. , Van Woensel Tom 
Published: February 2025

Next-day delivery logistics services are redefining the industry by increasingly focusing on customer service. Each logistics service provider’s challenge is jointly optimizing time window assignment and vehicle routing for such next-day delivery services. To do so in a cost-efficient and customer-centric fashion, real-life uncertainty, such as stochastic travel times, needs to be incorporated into the optimization process. This paper focuses on the canonical optimization problem within this context: the time window assignment traveling salesperson problem with stochastic travel times (TWATSP-ST). It belongs to two-stage, stochastic, mixed-integer programming problems with continuous recourse. We introduce two-step Benders decomposition with scenario clustering (TBDS) as an exact solution methodology for solving such stochastic programs. The method utilizes a new two-step decomposition along the binary and continuous first stage decisions and introduces a new scenario-retention strategy that combines and generalizes state-of-the-art Benders approaches and scenario-clustering techniques. Extensive experiments show that TBDS is superior to state-of-the-art approaches in the literature. It solves TWATSP-ST instances with up to 25 customers to optimality. It provides better lower and upper bounds that lead to faster convergence than existing state-of-the-art methods. We use TBDS to analyze the structure of the optimal solutions. By increasing routing costs only slightly, customer service can be improved tremendously driven by smartly alternating between high- and low-variance travel arcs to reduce the impact of delay propagation throughout the executed vehicle route. Funding: A. H. Schrotenboer has received support from the Dutch Science Foundation [Grant VI.Veni.211E.043]. Supplemental Material: The online appendix is available at https://doi.org/10.1287/trsc.2024.0750 .
How are Emotional and Physical Demands Associated with Job Dissatisfaction? Moderated by Marital Status
Authors: Elfira Tirsa , Kusmaryani Rosita Endang , Wibowo Yoga Setyo 
Published: February 2025

Although there has been extensive research on job satisfaction, the theoretical possibilities may be limited. In general, most of the research focuses only on job-demand factors. However, this study focuses on the emotional and physical demands on job satisfaction. Using the 5th wave of IFLS data, this study aims to determine the effect of marital status upon the relationship between emotional and physical demands on employee satisfaction in Indonesia. The results of research from 19,395 Indonesian employees show that marital status is a mediator in the relationship between emotional and physical demands on job satisfaction. The findings suggest that marital status underpins negative outcomes of emotional and physical demands on job satisfaction in Indonesia. Additionally, the present study found that gender differences affect job satisfaction. Traditional role values and gender concepts are discussed.Â demand; physical demands; marital status
Exclusionary by Design: Law, Lawyers, and State Harms in the UK’s Streamlined Asylum Process
Authors: Hodgson Natalie 
Published: February 2025

Abstract
In 2023, in response to the UK’s growing asylum backlog, the streamlined asylum process was introduced. This article uses the streamlined asylum process as a case study for exploring the relationship between the state, law, and lawyers in the context of state harms. The article argues that the streamlined asylum process was designed to both downplay the importance of legal advice and make it practically difficult for a person to access legal advice. In doing so, the Government undermined an important procedural protection and created a process that increased the risk that a person would be erroneously denied protection. Ultimately, the streamlined asylum process was a continuation of the Government’s exclusionary approach towards people seeking asylum and its hostility towards immigration lawyers. While the streamlined asylum process was purportedly a policy of inclusion, this article argues that the process was exclusionary by design.
Autonomy over Life: The Struggle against Capitalist Development in West Papua
Authors: Saunders Samira Homerang , Sherwood Angela , Whyte David 
Published: February 2025

Abstract
West Papua—the part of the island of Papua currently ruled by Indonesia—is a site of aggressive industrial development, with major industries in gas extraction, metallurgical mining, and agricultural plantation. It is also home to the third largest rainforest area in the world after the Amazon and Congo basins. This article analyzes the struggle by the Papuan people to resist the rapidly accelerating form of industrial development that is being imposed on them against their will. It highlights how extreme forms of state violence and a politically imposed settlement, against the will of the Papuan people, fuel an ongoing conflict. The article therefore argues that demands for the right to self-determination as a form of political autonomy cannot be separated from the struggle to retain basic control over the essential conditions for life in West Papua: food production and the protection of water and air quality. Moreover, it argues that resistance to the Indonesian state in West Papua must be understood as a struggle for autonomy in the widest possible sense: a struggle to assert autonomy over the entirety of social and economic reproduction.
Role of Mig-6 in adipose tissue: Implications for glucose metabolism and insulin resistance
Authors: Kim Ji Min , Lim Joung Youl , Choung Sorim , Kim Ok Soon , Joung Kyoung Hye , Lee Ju Hee , Kim Hyun Jin , Ku Bon Jeong 
Published: February 2025

Background
Insulin resistance is a hallmark of type 2 diabetes mellitus (T2DM) and is associated with metabolic disorders. Adipose tissue plays a crucial role in regulating whole-body energy balance and glucose homeostasis. Mitogen-inducible gene 6 (Mig-6) is a negative feedback regulator of receptor tyrosine kinases, including epidermal growth factor receptor (EGFR). This study aims to evaluate the role of Mig-6 in white adipose tissue (WAT) and its impact on systemic glucose homeostasis using Mig-6 transgenic mice.

Methods
Human visceral fat samples were obtained from four obese and three lean women undergoing hysterectomy. Adipocyte-specific Mig-6 knock-in (Mig-6AdKI) mice were generated and maintained on either a high-fat diet (HFD) or normal chow diet (NCD). Glucose tolerance tests (GTT) and insulin tolerance tests (ITT) were performed. We conducted histological examinations to observe tissue morphology and used quantitative PCR to assess adipokine mRNA expression.

Results
Mig-6 expression was significantly reduced in the adipose tissue of obese mice and humans. Mig-6AdKI mice exhibited improved glucose tolerance and insulin sensitivity under both NCD and HFD conditions, without changes in body weight or fat mass. The improvement in glucose homeostasis under NCD conditions was particularly noteworthy. Increased adiponectin mRNA levels were observed in the WAT of Mig-6AdKI mice. Meanwhile, histological analysis did not observe any changes in adipose tissue morphology that could explain the improvement in systemic glucose homeostasis, although there were tendencies towards increased adipocyte size and inflammation in HFD-fed Mig-6AdKI mice.

Conclusion
Adipose-specific overexpression of Mig-6 improves systemic glucose tolerance and insulin sensitivity, suggesting its potential as a target for both the treatment and prevention of diabetes. These findings provide a reference for further research targeting EGFR or Mig-6 in adipose tissue, highlighting the metabolic role of Mig-6 in glucose homeostasis.
Accuracy of the Modified Finnish Diabetes Risk Score (Modified FINDRISC) for detecting metabolic syndrome: Findings from the Indonesian national health survey
Authors: Cahyaningsih Indriastuti , Rokhman M. Rifqi , Sudikno  , Postma Maarten J. , van der Schans Jurjen 
Published: February 2025

Background
This study evaluated the diagnostic accuracy of the Modified Finnish Diabetes Risk Score (Modified FINDRISC) for detecting individuals with metabolic syndrome in Indonesia.

Methods
A dataset from the 2018 Indonesian National Basic Health Survey was analysed, and cases of metabolic syndrome were identified in accordance with both National Cholesterol Education Program Adult Treatment Panel III (NCEP-ATP III) and International Diabetes Federation (IDF) guidelines. Diagnostic accuracy of the Modified FINDRISC tool was evaluated using the Area Under the Receiver Operating Characteristic (AUC) curve, while optimal cut-off scores were determined by Youden’s Index.

Results
From 25,432 participants, the mean and standard deviation of the Modified FINDRISC score was 5.7 (SD 4.1). The prevalence of metabolic syndrome was 32.1% and 24.8% based on NCEP-ATP III and IDF criteria, respectively. Based on NCEP-ATP III criteria alone, the AUC of the Modified FINDRISC was 80.9% (80.3%-81.5%) with 74.0% sensitivity and 75.5% specificity. Similarly, based on IDF criteria, AUC was 88.9% (88.5%-89.3%) with 89.8% sensitivity and 75.8% specificity. The optimal cut-off score was 6 for both criteria, with 41.2% of the total participants above the cut-off who would require further confirmation tests.

Conclusion
Metabolic syndrome is prevalent in Indonesia, and the Modified FINDRISC tool offers good diagnostic accuracy for detecting such cases. Utilising Modified FINDRISC as a first-instance screening modality will reduce the number of people requiring further confirmation tests. Modified FINDRISC has the potential for use in daily clinical practice, and the cost-effectiveness of Modified FINDRISC should be further evaluated.
Effectiveness of mindfulness-based online therapy or internet-delivered cognitive behavioral therapy compared with treatment as usual among patients with persistent somatic symptoms: Protocol for a randomized controlled trial
Authors: Vangelova-Korpinen Velina , Liira Helena , Kurki Samu N. , Sainio Markku , Malmivaara Antti , Kanerva Mari , Stenberg Jan-Henry , Varonen Mikko , Venäläinen Mikko , Vuorela Piia , Arokoski Jari 
Published: February 2025

Background
Persistent somatic symptoms unexplained by a defined medical or psychiatric condition often include a component of central sensitization. Many treatment options are based on cognitive behavioral therapy. Effective widely available therapies are scarce. There are self-management programs and e-therapies that aim at overcoming the central sensitization by modifying interoceptive neural networks in the brain.

Objectives
This study aims to investigate the effect of a mindfulness-based amygdala and insula retraining (AIR) online program and an internet delivered therapist assisted therapy offered by Helsinki University Hospital (HUS iCBTpss) compared to treatment as usual (TAU) in the treatment of conditions causing persistent somatic symptoms.

Methods
We will perform a randomized controlled trial aiming at 360 patients. Consenting patients will be randomized to three study arms: online AIR program, HUS iCBTpss (both interventions as add-ons to TAU); and TAU. Functional ability and quality of life surveys will be collected from participants at baseline and at 3, 6, and 12 months after entering the study.

Conclusions
This study is one of the first to explore non-drug based online interventions developed to overcome the brain’s central sensitization and are available and accessible to patients both in primary and secondary care. The results will develop the management of the common, often debilitating persistent somatic symptoms related to many conditions unexplained by a defined somatic or psychiatric illness.

Trial registration number
NCT05212467.
Factors associated with the use of dental services in older adults in Peru
Authors: Cossio-Alva Bryan Alexis , Rojas Rubén Espinoza , Ruiz-Barrueto Miguel Angel , Atoche Giancarlo Becerra , Mejia Christian R. , Corrales-Reyes Ibraín Enrique 
Published: February 2025

Background
The use of dental services by older adults in Peru faces various challenges that impact both their oral and overall health. Several factors play a crucial role in obtaining adequate dental care.

Aims
To evaluate the factors associated with the use of dental services in older adults in Peru.

Methods
This study was an observational, analytical, and cross-sectional investigation that utilized data from multiple years (2018–2022) of the Demographic and Family Health Survey (ENDES, by its Spanish acronym). The use of dental services was assessed through a specific survey question and analyzed in association with various socio-demographic variables, employing both descriptive and analytical statistical methods.

Results
In the multivariable analysis, the likelihood of not utilizing dental services was higher among men aPR: 1.53 (95% CI: 1.45–1.61), those without health insurance aPR: 1.44 (95% CI: 1.36–1.53), those who self-identified as other races aPR: 1.22 (95% CI: 1.13–1.33), Afro-descendants aPR: 1.10 (95% CI: 1.01–1.19), whites aPR: 1.12 (95% CI: 1.01–1.25) according to education level, those with a physical limitation aPR: 1.24 (95% CI: 1.15–1.33), and increased as they were poorer; it was lower among the rich but more pronounced among the middle-income, poor, and very poor, adjusted for five variables.

Conclusion
It was reported that 15% of older adults did not use dental services, and this was associated with significant socio-demographic variables.
The relation of nasopharyngeal colonization by Streptococcus pneumoniae in comorbid adults with unfavorable outcomes in a low-middle income country
Authors: Olivella-Gomez Juan , Lozada Julián , Serrano-Mayorga Cristian C. , Méndez-Castillo Lina , Acosta-González Alejandro , Viñán Garcés André Emilio , Bustos Ingrid G. , Ibáñez-Prada Elsa D. , Fuentes Yuli V. , Crispin Ana M. , Garcia-Garcia Erica Y. , Santana Eveling , Josa Diego F. , Pulido Saenz Jorge , Rodíguez-Castaño Gina Paola , Rodríguez Orjuela Jorge Alberto , Jaimes Diego , Tettelin Hervé , Orihuela Carlos J. , Reyes Luis Felipe 
Published: February 2025

Purpose
Streptococcus pneumoniae (Spn) is the primary bacterial cause of lower respiratory tract infections (LRTI) globally, particularly impacting older adults and children. While Spn colonization in children is linked to LRTI, its prevalence, and consequences in adults with comorbidities remain uncertain. This study aims to provide novel data in that regard.

Methods
This prospective study of outpatient adults with chronic diseases was conducted in Colombia. Data on demographics, vaccination, and clinical history was collected in a RedCap database. Nasopharyngeal aspirate samples were examined for Spn colonization using traditional cultures and quantitative—real time polymerase chain reaction (q-rtPCR). Patients were followed for 18 months, with colonization prevalence calculated and factors influencing colonization and its impact on clinical outcomes analyzed through logistic regressions.

Results
810 patients were enrolled, with 10.1% (82/810) identified as colonized. The mean (SD) age was 62 years (±15), and 48.6% (394/810) were female. Major comorbidities included hypertension (52.2% [423/810]), cardiac conditions (31.1% [252/810]), and chronic kidney disease (17.4% [141/810]). Among all, 31.6% (256/810) received the influenza vaccine in the previous year, and 10.7% (87/810) received anti-Spn vaccines. Chronic kidney disease (OR 95% CI; 2.48 [1.01–6.15], p = 0.04) and chronic cardiac diseases (OR 95% CI; 1.62 [0.99–2.66], p = 0.05) were independently associated with Spn colonization. However, colonization was not associated with the development of LRTI (OR 95%CI; 0.64 [0.14–2.79], p = 0.55) or unfavorable outcomes (OR 95% CI;1.17 [0.14–2.79], p = 0.54) during follow-up.

Conclusions
Chronic kidney and cardiac diseases are independently associated with Spn colonization. However, Spn colonization was not associated with LRTI/unfavorable outcomes in adult patients with chronic comorbidities in our cohort.
Effect of Glucagon-Like Peptide-1 Receptor Agonists on Bowel Preparation for Colonoscopy: A Systematic Review and Meta-Analysis
Authors: Beran Azizullah , Nayfeh Tarek , Akhras Aya , Ramai Daryl , Mohamed Mouhand , Guardiola John J. , Al-Haddad Mohammad , Rex Douglas K. 
Published: February 2025

Introduction:
The impact of glucagon-like peptide-1 receptor agonists (GLP-1RAs) on colonoscopy bowel preparation is unclear.

Methods:
We searched multiple databases for studies comparing bowel preparation quality between GLP-1RA users and control group. Using a random-effects model, we calculated pooled odds ratios (OR) and mean differences (MD) with 95% confidence intervals (CIs). Inadequate bowel preparation (IBP) rate was the primary outcome and Boston Bowel Preparation Scale (BBPS) mean score was the secondary outcome.

Results:
Five studies with 10,833 subjects (n=5,434 GLP-1RAs vs. n=5,399 control) were included. The IBP rate was higher in the GLP-1RAs group compared to the control group (OR 2.10, 95% CI 1.41-3.13, p=0.0003). Furthermore, the mean BBPS score was lower in the GLP1-RAs group compared to the control group (MD -0.34; 95% CI -0.51, -0.17; p=0.0001).

Conclusions:
Our findings suggest that using GLP-1RA increases the risk of inadequate bowel preparation.
Pediatric Cancer: Promoting Desired School Outcomes Through Collaboration
Authors: Hay Genevieve Howe 
Published: February 2025

Due to medical advances, many students with pediatric cancer are able to attend school. The professional literature reflects the need for enhanced collaboration between medical and educational personnel to address the academic and health care needs of children undergoing cancer treatment and who may experience late effects throughout their academic careers. To promote effective educational services during and after treatment, it is crucial for multidisciplinary teams and families to collaborate effectively. Additionally, preservice and in-service teachers need training and support to meet the needs of students with cancer.
Keywords: pediatric cancer, collaboration, hospital-based school liaison, school-based liaison, school psychologist, school nurse, classroom teacher
The Effects of Applying the ELI Recommendations for Corporate Sustainability: Illustrative Examples
Authors: Hossfeld Christopher 
Published: February 2025

Abstract
In the last two decades new forms of distributions to shareholders such as share buybacks have found their way in standard dividend distribution policies of companies. Also, accounting rules have evolved and refer nowadays more to fair value consideration (for example in IFRS) which leads to an increased recognition of unrealised profits in distributable profits. The European Law Institute (ELI) recommendations (Biondi, Yuri, Colin Haslam and Corrado Malberti. 2025. “ELI Guidance on Company Capital and Financial Accounting for Corporate Sustainability.” Accounting, Economics, and Law: A Convivium 15 (s1): s21–88.) propose to modernise European company law regarding distributions, equity capital maintenance, and non-distributable reserves. The aim of the ELI recommendations is to ensure that payments made to shareholders, primarily in the form of dividends but also share buybacks, do not worsen the financial situation of companies and, therefore, endanger their continuity and resilience through time and circumstances, undermining their long-term capacity to cope with social and environmental commitments. We provide illustrative examples for eight ELI recommendations: restricting the dividend distribution of share premiums, stricter legal reserve requirements, the setting up of non-distributable reserves for gains from certain accounting measurements, for current value measurement of provisions, for capitalized development costs, for equity method holding gains, for held own-shares, and for goodwill. Our numerical examples show how the application of the ELI recommendations limits distributable profits and, therefore, contributes to sustain a sound financial situation of companies.
ELI Guidance on Company Capital and Financial Accounting for Corporate Sustainability
Authors: Biondi Yuri , Haslam Colin , Malberti Corrado 
Published: February 2025

Abstract
The European Law Institute – ELI Guidance proposes a set of Recommendations on company capital and financial accounting for corporate sustainability aimed at: (i) providing a frame of reference and analysis to understand corporate sustainability in the context of business and law; (ii) pointing to specific issues which need to be addressed by European and national lawmakers and regulators; and (iii) establishing a set of company law instruments which set out possible solutions to cope with these issues. The Recommendations aim at restating and modernising well-established principles of European company law on: (i) distributions; (ii) equity capital maintenance; and (iii) non-distributable reserves. Specific attention was paid to the enhanced controlling of new kinds of distributions such as share buybacks, as well as to limiting distributions of non-realised gains. The Project Team developed a comprehensive set of Recommendations aimed at fostering and facilitating sustainable business conduct through responsible company capital management and financial accounting adjustments. Further Recommendations were provided on related policy and regulatory matters concerning the EU framework for corporate sustainability. As a whole, the Recommendations propose that companies commit to a prudent use of resources, by setting aside sufficient reserves to meet social and environmental commitments over long-term horizons, and establish a fair balance between these commitments and distributions to shareholding investors. Corporate sustainability may be enhanced by implementing controls over distributions while reinforcing reserve provisioning. This in turn will ensure company continuity and resilience, as well as financial stability and sustainable development for the benefit of business and society at large.
Quantization effects for multi-component Ginzburg-Landau vortices
Authors: Hadiji Rejeb , Han Jongmin , Sohn Juhee 
Published: February 2025

Abstract
In this paper, we are concerned with n-component Ginzburg-Landau equations on

R

2

${\mathbb{R}}^{2}$

. By introducing a diffusion constant for each component, we discuss that the n-component equations are different from n-copies of the single Ginzburg-Landau equations. Then, the results of Brezis-Merle-Riviere for the single Ginzburg-Landau equation can be nontrivially extended to the multi-component case. First, we show that if the solutions have their gradients in L
2 space, they are trivial solutions. Second, we prove that if the potential is square summable, then it has quantized integrals, i.e., there exists one-to-one correspondence between the possible values of the potential energy and

N

n

${\mathbb{N}}^{n}$

. Third, we show that different diffusion coefficients in the system are important to obtain nontrivial solutions of n-component equations.