bluuebunny/crossref_metadata_2025_split huggingface dataset:
Breast conservation versus mastectomy for metaplastic breast cancer: A systematic review and meta‐analysis
Authors: Harris Christopher G , Azimi Farhad , Chan Belinda , Graham Susannah , Mak Cindy , Warrier Sanjay , Eslick Guy D 
Published: May 2024

AbstractMetaplastic breast cancer is a rare aggressive subtype of breast cancer for which there are no clear treatment guidelines regarding the optimal surgical approach. This systematic review and meta‐analysis aimed to evaluate survival outcomes of patients with metaplastic breast cancer undergoing breast conservation compared with mastectomy. We identified studies from MEDLINE, Pubmed, EMBASE, Google Scholar, the Cochrane Library Register of Controlled Trials and the EBM Reviews Register. Studies were deemed suitable for inclusion where they compared breast‐conserving surgery to mastectomy with the primary outcome of overall survival. Survival data were pooled using a random‐effects model.From the 456 citations screened by our search, three studies were assessed as eligible for inclusion. There were a total of 2995 patients who underwent mastectomy and 1909 who underwent breast conservation. The median follow‐up time was 43 months. Meta‐analysis demonstrated no significant difference between breast conservation and mastectomy (pooled HR 0.89, 95% CI, 0.56–1.42, p = 0.631). Wide local excision, in conjunction with adjuvant radiation and judicious use of chemotherapy, may be a reasonable alternative to mastectomy as surgical management of metaplastic breast cancer as part of an individualized, multidisciplinary approach.
The use of in‐hospital guidelines for prevention of sudden unexpected postnatal collapse: A national survey
Authors: Bergman Klasien A. , Bouma Bea A. , Semmekrot Ben A. , Matthijsse René P. , Reiss Irwin K. M. , Ikkink Henrike Klein , Hulzebos Christian V. 
Published: May 2024

AbstractAimSudden unexpected postnatal collapse is a life‐threatening event and may occur in any newborn infant. Safe skin‐to‐skin contact, and awareness of sudden unexpected postnatal collapse are key to its prevention. The aim of this study was to survey the presence of skin‐to‐skin contact and/or sudden unexpected postnatal collapse protocols in the 70 perinatal centres in the Netherlands.MethodsWe performed a survey among Dutch paediatricians to examine the safe skin‐to‐skin contact and sudden unexpected postnatal collapse protocols.ResultsWe received data from 59/70 (85%) perinatal centres. At least one case of sudden unexpected postnatal collapse was reported in 35/59 (59%) of these centres. Nearly half the centres had safe skin‐to‐skin contact and/or sudden unexpected postnatal collapse protocols. Ultimately, 16 protocols were available for analysis. They showed considerable differences in the type of perinatal care provided. Most protocols lacked recently published insights on safe skin‐to‐skin contact. Besides, protocols failed to incorporate awareness of and knowledge on how to prevent sudden unexpected postnatal collapse.ConclusionThis study underlines the importance of drawing up uniform, multidisciplinary guidelines containing recommendations for the prevention of sudden unexpected postnatal collapse in the Netherlands.
Robotic‐assisted native pyeloureterostomy with indocyanine green, after kidney transplantation
Authors: Khalil Nour , Sarkis Julien , Ingels Alexandre 
Published: May 2024

AbstractIntroductionPostoperative ureteral strictures and vesicoureteral reflux after ureteroneocystostomy for kidney transplant can be managed by endoscopic procedures like balloon dilation and endoscopic injections. Complicated/recurrent cases, however, are usually managed by reconstructive surgery. We hereby highlight our technique of robotic‐assisted native pyeloureterostomy with indocyanine green (ICG).Materials and Surgical TechniqueA 57‐year‐old woman, diagnosed with grade 4 vesicoureteral reflux on her transplanted kidney, was considered a candidate for ureteral reimplantation.After an endoscopic part, where the ICG is inserted into the renal pelvis, we proceed with the robotic native pyeloureterostomy. The renal pelvis of the transplanted kidney was identified with the help of the ICG in firefly mode. After the dissection of the graft pelvis, we performed a tension‐free pyeloureterostomy using the native ureter. The postoperative course was uneventful and the patient was discharged on the third postoperative day.DiscussionRobotic‐assisted pyelo‐ureterostomy appears as a safe and efficient technique for management of complicated urological complications postrenal transplantation using the native ureter. Intrapelvic ICG injection, not possible with open surgery, helps identifying the grafted pelvis thus reducing operative time and avoiding unnecessary dissection of the vascular hilum of the graft. Because of minimal dissection and the short operative time, abdominal drainage is unnecessary and the postoperative course is usually uneventful with a fast discharge from the hospital.
Completion lobectomy under 4K three‐dimensional endoscopy for surgical margin recurrence after segmentectomy
Authors: Mimura Takeshi , Haraguchi Shintaro , Ishida Masayuki , Kagimoto Atsushi 
Published: May 2024

AbstractAs the adoption of segmentectomy for small‐sized lung cancers expands, the need for more challenging completion lobectomy (CL) may arise to address surgical margin recurrence. Herein, we present a case of successful CL using a 4K three‐dimensional (3D) (4K3D) endoscopy after segmentectomy. A 77‐year‐old male patient with lung cancer in the anterior segment (S3) of the left upper lobe underwent S3 segmentectomy. One year later, the patient experienced a recurrence at the surgical margin. CL was successfully performed under 4K3D endoscopy, same as the initial surgery. CL after segmentectomy requires meticulous preoperative planning and precise surgical maneuvering, and 4K3D endoscopy provides safe and reliable outcomes.
Effects of abrupt and gradual light/dark switching on growth performance, behavior, villus development, meat characteristics, and immunity of broilers
Authors: Gündoğar Umut Can , Onbaşılar Esin Ebru , Ahlat Ozan 
Published: May 2024

AbstractThe aim of this study is to determine the effect of abrupt and gradual light/dark switching on growth performance, behavior, villus development, meat characteristics, and immunity of broilers. A total of 270 daily male broiler chicks were used in the experiment. The study comprised three groups based on whether the transitions between light and dark periods were abrupt or gradual. No significant differences were observed among the examined groups in terms of body weight, weight gain, mortality rate, feeding, pecking, relaxing, and feather preening behaviors, carcass, and breast meat quality characteristics. Total body weight gain, total feed consumption, total feed utilization ratio, and mortality rates of broilers during the 6‐week fattening period did not differ compared to the abrupt transition. Broilers in the group with gradual transition exhibited less movement, more sitting, and sleeping behaviors. It was determined that the IgG was higher in the gradual transition group. The transitions between light and dark periods influenced the characteristics of thigh meat. Villus height and crypt depth were higher in the group where a 1‐h gradual transition was applied. As a conclusion, gradual transition is more appropriate in broiler rearing.
Concurrent nimotuzumab and intensity‐modulated radiotherapy for elderly patients with locally advanced nasopharyngeal carcinoma
Authors: Cao Caineng , Fang Yuting , Jiang Feng , Jin Qifeng , Jin Ting , Huang Shuang , Hu Qiaoying , Chen Yuanyuan , Piao Yongfeng , Hua Yonghong , Feng Xinglai , Chen Xiaozhong 
Published: May 2024

AbstractBecause of the common physical condition, reduced organ function, and comorbidities, elderly patients with nasopharyngeal carcinoma (NPC) are often underrepresented in clinical trials. The optimal treatment of elderly patients with locally advanced NPC remains unclear. The purpose of this study was to evaluate the efficacy of concurrent nimotuzumab combined with intensity‐modulated radiotherapy (IMRT) in elderly patients with locally advanced NPC. We conducted a single‐arm, phase II trial for elderly patients with stage III–IVA NPC (according to UICC–American Joint Committee on Cancer TNM classification, 8th edition). All patients received concurrent nimotuzumab (200 mg/week, 1 week prior to IMRT) combined with IMRT. The primary end‐point was complete response (CR) rate. The secondary end‐points were survival, safety, and geriatric assessment. Between March 13, 2017 and November 12, 2018, 30 patients were enrolled. In total, 20 (66.7%) patients achieved CR, and objective response was observed in 30 (100.0%) patients 1 month after radiotherapy. The median follow‐up time was 56.05 months (25th–75th percentile, 53.45–64.56 months). The 5‐year locoregional relapse‐free survival, distant metastasis‐free survival, cancer‐specific survival, disease‐free survival, and overall survival were 89.4%, 86.4%, 85.9%, 76.5%, and 78.8%, respectively. Grade 3 mucositis occurred in 10 (33%) patients and grade 3 pneumonia in 3 (10%) patients. Concurrent nimotuzumab combined with IMRT is effective and well‐tolerated for elderly patients with locally advanced NPC.
Design, synthesis, and antibacterial activity of pleuromutilin derivatives
Authors: Liu Hui‐xian , Yao Wen‐yu , Cui Ge , Zhou Jing , Yan Hao , Guo Hui , Wang Yu‐wei , Zhang Yue 
Published: May 2024

AbstractThis paper reports the design, synthesis, and antibacterial activity study of pleuromutilin derivatives with 2‐methyl‐4‐nitroaniline and 2‐methoxy‐4‐nitroaniline side chains at the C22 position. The structures of the new compounds were characterized by 1H‐NMR, 13C‐NMR and HRMS. The inhibitory activity of the compounds against MSSA, pyogeniccoccus, streptococcus, and MRSA strains was determined using the micro broth dilution method. The results showed that the compounds exhibited certain activity against Gram‐positive bacteria, among which compounds A8a, A8b, A8c, A8d, and A7 demonstrated superior antibacterial activity against MSSA, MRSA, and pyogeniccoccus compared to tiamulin, although the derivatives showed lower antibacterial activity against streptococcus compared to the control drug. Based on the favorable in vitro activity of A8c, the time‐kill kinetics against MRSA were evaluated, revealing that compound A8c could inhibit bacterial proliferation in a concentration‐dependent manner.
Prospective observational cohort study of the change of the marginal bone crest in relation to the prosthetic abutment height and the peri‐implant vertical mucosal thickness at implants positioned subcrestally
Authors: Maza‐Solano Serafín , Baus‐Domínguez María , Romero‐Ruíz Manuel‐María , Gutiérrez‐Corrales Aida , Torres‐Lagares Daniel , Serrera‐Figallo María‐Ángeles 
Published: May 2024

AbstractAimTo evaluate the influence on peri‐implant crestal bone loss exerted by the vertical mucosal thickness and the abutment height over 12 months after placement of the restoration on subcrestal implants with change of platform, using a restoration abutment platform smaller than the implant platform.Materials and MethodsA total of 99 implants were rehabilitated in the maxillary and mandibular posterior regions. A total of 22 implants were rehabilitated in the maxilla and 77 implants in the mandible, using digitally designed customized abutments with Atlantis weborder software, from the commercial house Dentsply Sirona (Dentsply Sirona S.A., Barcelona, Spain), version 4.6.5, adapting the height to the vertical thickness of the mucosa. Clinical and radiographic monitoring begins during the surgical procedure of placement of the implant and ends 12 months afterwards. Crestal bone loss was evaluated through the Carestream® CS8100 3D radiographic equipment.ResultsIn all cases, the greatest loss of marginal bone occurred between the day of surgery (Tx) and placement of the rehabilitation (To). The average bone loss between both times was greater when the abutment height and vertical mucosal thickness did not exceed 3 mm. Subsequently, bone loss slowed and stabilized at 12 months.ConclusionsThe minimum abutment height and the vertical mucosal thickness are factors to take into account when minimizing peri‐implant marginal bone loss, the abutment height having the greatest importance according to the clinical data obtained.
Tissue changes around dental implants installed in alveolar ridge preservation sites: A 1‐year follow‐up randomized controlled clinical trial
Authors: Gabay Eran , Regev Eli , Mayer Yaniv , Horwitz Jacob , Asbi Thabet , Ginesin Ofir , Zigdon‐Giladi Hadar 
Published: May 2024

AbstractObjectiveThis study aimed to assess radiographic marginal bone changes 22 months post extraction, which is 1 year after implant loading in alveolar ridge preservation (ARP) sites grafted with a combination of collagen‐embedded xenogenic bone substitute (DBBM‐C) and collagen matrix (CMX), comparing them with implants placed in naturally healed sites.MethodsThis randomized controlled clinical trial was conducted over 22 months. Patients who needed a single tooth extraction and subsequent implant placement in nonmolar areas were enrolled. The test group received deproteinized bovine bone mineral with 10% collagen covered by a procaine collagen membrane, while the control group allowed spontaneous healing. Radiographic bone level changes were documented using periapical radiographs at implant placement and follow‐up visits (6, 10, and 22 months postextraction). Early implant soft tissue exposure, clinical parameters, and patient‐reported outcomes were recorded.ResultsTwenty‐two out of 28 participants completed a 22‐month follow‐up, 9 in the test group and 13 in the control group. At 10‐month postextraction follow‐up, the mean MBL was 1.01 ± 1.04 mm in the treatment group and 0.81 ± 0.93 mm in the control group (p = 0.804). At 22 months, the mean MBL was 2.09 ± 1.03 mm in the treatment group and 1.58 ± 0.73 mm in the control group (p = 0.339). No statistically significant differences in probing depth (PD) and bleeding on probing (BOP) were found at the 22 ‐month follow‐up as well. Soft tissue mean recession was observed in the control group (0.36 ± 0.84 mm), while no recession was found in the test group (p = 0.2). Early implant soft tissue exposure occurred in 33% of test group participants, while none was observed in the control group (p = 0.047).ConclusionOne year after implant loading, no significant differences in marginal bone resorption were found between implants placed in ARP‐treated and naturally healed sites. However, ARP‐treated sites exhibited early implant soft‐tissue exposure, suggesting a possible impairment in soft tissue healing.
Ultraconserved elements from transcriptome and genome data provide insight into the phylogenomics of Sternorrhyncha (Insecta: Hemiptera)
Authors: Liu Dajun , Cui Jinyu , Liu Yubo , Niu Minmin , Wang Fang , Zhao Qing , Cai Bo , Zhang Hufang , Wei Jiufeng 
Published: May 2024

AbstractSternorrhyncha, one of the four major suborders of Hemiptera, is a phytophagous taxon inclusive of nearly 18 000 described species. The phylogenetic relationships within the taxon and the earliest‐branching lineage of its infraorders remain incompletely understood. This study attempted to illuminate the phylogenetic relationships within Sternorrhyncha through the use of maximum likelihood, Bayesian inference and maximum parsimony analyses, employing ultraconserved element (UCE) data from 39 genomic and 62 transcriptomic datasets and thereby representing most families within the taxon. The probe set Hemiptera 2.7Kv1 was used to recover a total of 2731 UCE loci: from 547 to 1699 (with an average of 1084) across all genomic datasets and from 108 to 849 (with an average of 329) across all transcriptomic datasets. All three types of phylogenetic analyses employed in this study produced robust statistical support for Sternorrhyncha being a monophyletic group. The different methods of phylogenetic analysis produced inconsistent descriptions of topological structure at the infraorder level: while maximum likelihood and Bayesian inference analyses produced strong statistical evidence (100%) indicating the clade Psylloidea + Aleyrodoidea to be a sister of the clade Aphidoidea (Aphidomorpha) + Coccoidea (Coccomorpha), the maximum parsimony analysis failed to recover a similar result. Our results also provide detail on the phylogenetic relationships within each infraorder. This study presents the first use of UCE data to investigate the phylogeny of Sternorrhyncha. It also shows the viability of amalgamating genomic and transcriptomic data in studies of phylogenetic relationships, potentially highlighting a resource‐efficient approach for future inquiries into diverse taxa through the integration of varied data sources.
Evaluating drivers of recent large whale strandings on the East Coast of the United States
Authors: Thorne L. H. , Wiley D. N. 
Published: May 2024

AbstractAnthropogenic stressors threaten large whales globally. Effective management requires an understanding of where, when, and why threats are occurring. Strandings data provide key information on geographic hotspots of risk and the relative importance of various threats. There is currently considerable public interest in the increased frequency of large whale strandings occurring along the US East Coast of the United States since 2016. Interest is accentuated due to a purported link with offshore wind energy development. We reviewed spatiotemporal patterns of strandings, mortalities, and serious injuries of humpback whales (Megaptera novaeangliae), the species most frequently involved, for which the US government has declared an “unusual mortality event” (UME). Our analysis highlights the role of vessel strikes, exacerbated by recent changes in humpback whale distribution and vessel traffic. Humpback whales have expanded into new foraging grounds in recent years. Mortalities due to vessel strikes have increased significantly in these newly occupied regions, which show high vessel traffic that also increased markedly during the UME. Surface feeding and feeding in shallow waters may have been contributing factors. We found no evidence that offshore wind development contributed to strandings or mortalities. This work highlights the need to consider behavioral, ecological, and anthropogenic factors to determine the drivers of mortality and serious injury in large whales and to provide informed guidance to decision‐makers.
Nutrients and drought alter tri‐trophic interactions in cool‐temperate forests
Authors: Chaij Jaquelina Marisa , Aranda Melina Jeanette , Chaneton Enrique José , Mazía Noemi 
Published: May 2024

Abstract
Herbivorous insects are the main consumers in forest ecosystems, and the complexity of trophic interactions varies with resource availability, heterogeneity among feeding guilds and the presence of natural enemies. In this study, we examined tri‐trophic interactions in Nothofagus pumilio (Fagales: Nothofagaceae) Poepp. & Endl. Krasser forests in southern South America. Specifically, we focused on the effect of nitrogen addition and a drought event on levels of insect herbivory by different feeding guilds and the rate of parasitism on leaf miners throughout the growing season (middle and late).
Nitrogen (N) addition increased the foliar nitrogen content but had no effect on total damage by arboreal insects. However, the different feeding guilds responded differently to nitrogen addition, and these responses varied between average or dry year and within the growing season. Particularly, miner activity responded positively to nitrogen addition, increasing their incidence towards the late season of the average year. The positive effect of nitrogen addition on miner activity did not cascade up to the trophic level of parasitoids, which varied with the climatic context and the growing season.
These results suggest that tri‐trophic interactions were mainly controlled by the climatic context, since consumers and their natural enemy responses were more dependent on the climatic context and growing seasons than on plant quality. Overall, we highlight the role of fluctuating abiotic resources and the heterogeneity within each trophic level in structuring tri‐trophic interactions in forest ecosystems.
Short‐selling restriction and return predictability: Evidence from China
Authors: Jiang Ying , Qiu Jiayan , Sun Qian 
Published: May 2024

AbstractWe examine how the ban on t+0 short selling affects the return predictability of short sellers in China. If the ban drives out mostly less informed short sellers, then the return predictive power should be enhanced. However, if the ban drives out more informed short sellers instead of less informed short sellers, then the return predictability should worsen. We find that in China, where the stock market is dominated by retail investors, and short‐selling activities are not active, the ban is likely to drive out more informed short sellers, and thus, worsen the predictive power of short selling.
ENGAGEMENT IN BRIEFEN: FANNY TARNOWS TEILHABE AN DEN EREIGNISSEN VON 1848/49 ANHAND IHRER KORRESPONDENZ AUS DEN 1830ER UND 1840ER JAHREN
Authors: Dampc‐Jarosz Renata 
Published: May 2024

AbstractIn the time preceding, during, and following the revolution in France, Germany, and other European nations in 1848/49, numerous women writers actively participated in the fight for freedom and democracy. However, their involvement manifested in diverse forms. Besides the women categorised as ‘activist’ writers, there were others whose ‘engagement’ was less overt and public. Nevertheless, they too contributed through their writing and ideological alignment with the progressive political movements of their era. This article describes such subversive forms of engagement, using Fanny Tarnow and her correspondence with Karl August Varnhagen von Ense from 1833 to 1849 as a focal point for analysis. Central to this analytical framework is the notion of a dialogical exchange through letters, which served as a cornerstone for both Tarnow and Varnhagen in comprehending their socio‐political roles as mature writers navigating a new era's political landscape and community.