bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Survey of Hardware Improvements to Secure Program Execution
Authors: Zhao Lianying , Shuang He , Xu Shengjie , Huang Wei , Cui Rongzhen , Bettadpur Pushkar , Lie David 
Published: June 2024

Hardware has been constantly augmented for security considerations since the advent of computers. There is also a common perception among computer users that hardware does a relatively better job on security assurance compared with software. Yet, the community has long lacked a comprehensive study to answer questions such as how hardware security support contributes to security, what kind of improvements have been introduced to improve such support and what its advantages/disadvantages are.
By generalizing various security goals, we taxonomize hardware security features and their security properties that can aid in securing program execution, considered as three aspects, i.e., state correctness, runtime protection and input/output protection. Based on this taxonomy, the survey systematically examines (1) the roles: how hardware is applied to achieve security; and (2) the problems: how reported attacks have exploited certain defects in hardware. We see that hardware’s unique advantages and problems co-exist and it highly depends on the desired security purpose as to which type to use. Among the survey findings are also that code as part of hardware (aka. firmware) should be treated differently to ensure security by design; and how research proposals have driven the advancement of commodity hardware features.
Distribution of the Joint Survival Function of an Archimedean Copula
Authors: Djimdou Magloire Loudegui , Chaubey Yogendra P. , Sen Arusharka 
Published: June 2024

Suppose a random vector [Formula: see text] with values in the unit cube has a joint survival function: [Formula: see text] given by an Archimedean copula [Formula: see text] with generator [Formula: see text], a smooth decreasing convex function such that [Formula: see text]. In this article, we provide a formula for the distribution of [Formula: see text] where [Formula: see text] is an independent copy of [Formula: see text] and a method to simulate values from the distribution of Z in the bivariate case, that is, when d = 2. The case d > 2 does not seem to be tractable. As an application, we show how our result can be used to compute the limiting covariance of the empirical Kendall process corresponding to [Formula: see text]. AMS Subject Classification: 62H05
Conceptual Volume Expansion During the Reaction of Polyurethanes
Authors: Proksa F. 
Published: June 2024

The free foaming of polyurethane is presented as the expansion of gas bubbles in a fluid. The expansion process is described by mechanical stress on the bubble walls, which have undergone a strainflow. A modification of Newton's flow law for viscous fluids, whereby the strain rate is proportional to the stress, is used. In an extension of Newton's flow law the proportionality factor is assumed to be not a constant but, rather, a time-dependent quantity. This takes into account the changing viscosity during the foaming process. Power law approaches for the time dependencies of the fluidity (reciprocal value of the viscosity) and the excess pressure of the bubble leads to results which reflect the measured rising curves quite well.
Outcomes associated with absent blood product utilization in Jehovah’s witness patients compared to the standard of care in cardiac surgery: A ten-year experience
Authors: Fields Nathan , Ather Ayesha , Davenport Dan , Ahmed Sadiq , Sekela Michael 
Published: June 2024

Introduction For Jehovah’s Witness (JW) patients requiring cardiac surgery, various strategies such as preoperative use of erythropoietin stimulating agents (ESAs), intravenous iron (IVI), and non-pharmacologic interventions have emerged to prevent complications from blood loss given transfusion is not acceptable in this population. Methods Retrospective case-control of cardiac surgeries performed by the same surgeon between 1/1/2011 and 8/30/2021. JW patients were matched to non-JW who received blood products and non-JW who did not receive blood products on a 1:2:2 basis. Patients were matched on procedure, age, gender, and Society of Thoracic Surgeons morbidity score. Eligible patients were aged >18 years and had a sternotomy procedure. The primary efficacy and safety outcomes included mean hematocrit values perioperatively and thrombotic events. Results A total of 27 JW, 52 non-JW transfused, and 53 non-JW not transfused patients were included in the analysis. JW patients had significantly higher mean hematocrits at every time point when compared to non-JW transfused patients and at all time points except clinic and the last recorded operating room value when compared to non-JW not transfused patients. No significant differences in thrombotic rates were found between groups, however there was a numerically higher incidence in the JW population (JW: 7.4%; non-JW transfused: 0%; non-JW not transfused: 1.9%; p = .106). Conclusion A blood conservation protocol in a JW population was associated with higher perioperative hematocrit values when compared to matched controls. Further prospective study is warranted before applying similar protocols to other populations given the possibility for an increased rate of venous thromboembolism.
Long-term outcomes of total arch replacement with bilateral antegrade cerebral perfusion using the “arch first” approach
Authors: Brown James A , Yousef Sarah , Serna-Gallegos Derek , Sá Michel Pompeu , Agrawal Nishant , Thoma Floyd , Wang Yisi , Phillippi Julie , Sultan Ibrahim 
Published: June 2024

Objective To report outcomes of total arch replacement (TAR) with hypothermic circulatory arrest and bilateral antegrade cerebral perfusion (bACP) using an “arch first” approach for acute Type A aortic dissection (ATAAD). The “arch first” approach involved revascularization of the aortic arch branch vessels with uninterrupted ACP, before lower body circulatory arrest, while the patient was cooling. Methods This was an observational study of aortic surgeries from 2010 to 2021. All patients who underwent TAR with bACP for ATAAD were included. Short-term and long-term outcomes were reported utilizing descriptive statistics and Kaplan-Meier survival estimation. Results A total of 215 patients were identified who underwent TAR + bACP for ATAAD. Age was 59.0 [49.0–67.0] years and 35.3% were female. 73 patients (34.0%) underwent a concomitant aortic root replacement, 188 (87.4%) had aortic cannulation, circulatory arrest time was 37.0 [26.0–52.0] minutes, and nadir temperature was 20.8 [19.4–22.5] degrees Celsius. 35 patients (16.3%) had operative mortality (STS definition), 17 (7.9%) had a new stroke, 79 (36.7%) had prolonged mechanical ventilation (>24 h), 35 (16.3%) had acute renal failure (by RIFLE criteria), and 128 (59.5%) had blood product transfusions. One-year survival was 77.1%, while 5-years survival was 67.1%. During follow-up, there were 23 (10.7%) reinterventions involving the descending thoracic aorta – either thoracic endovascular aortic repair or open thoracoabdominal aortic replacement. Conclusions Among patients with ATAAD, short-term postoperative outcomes after TAR + bACP using the “arch first” approach are acceptable. Moreover, this operative strategy may furnish long-term durability, with a reasonably low reintervention rate and satisfactory overall survival.
The pseudoscience of lithium and suicide: Reanalysis of a misleading meta-analysis
Authors: Ghaemi Seyyed Nassir 
Published: June 2024

By manipulating inclusion criteria, one can prove whatever point one wishes in meta-analysis. This critique examines a recent meta-analysis claiming lithium ineffectiveness for suicidality, based on three biased features: inclusion of many large studies specifically designed to exclude suicidality, producing zero suicide outcomes in all groups ( n = 1856), thereby artificially decreasing statistical significance; arbitrary exclusion of all trials prior to the year 2000, thereby excluding two randomized clinical trials which demonstrated benefit for lithium; and underreporting of placebo suicide events in a recent randomized trial. It thereby created a smaller effect size (two suicides with lithium versus five with placebo = RR = 0.42), though still beneficial for lithium, and a larger denominator of no events (total n for included studies = 2578), leading to the claim of statistical non-significance (95% confidence intervals (CIs) 0.1–4.5). The same literature can be analyzed including the two excluded older studies, and including the two placebo deaths in the recent trial, producing a larger effect size (two suicides with lithium versus nine with placebo, RR = 0.25). Furthermore, uninformative studies with no events could be excluded (total n for included studies = 1203), as is standard practice in meta-analysis, producing statistically significant results (95% CIs 0.05, 0.83). This more complete, more accurate, and less biased meta-analysis is provided in this article. In short, including all studies with non-zero suicide outcomes, there is clear benefit for lithium. The recent meta-analysis is a classic example of pseudoscience, using scientific technique superficially to confirm, rather than refute, one’s own opinions.
Biomarkers of occupational benzene exposure: A Systematic Review to estimate the exposure levels and individual susceptibility at low doses
Authors: Zhang Zhijuan , Shi Wenmin , Ru Lihua , Lv Wei 
Published: June 2024

Benzene is associated with diverse occupational and public health hazards. It exhibits an ability to rapidly permeate the skin and contaminate water and food sources, leading to dermal and ingestion exposures. Despite numerous studies examining the associations between benzene and various indicators of harm, the findings have yielded inconsistent results. Furthermore, relying solely on air concentration as a measure of benzene exposure is limited, as it fails to account for internal exposure dose and individual susceptibility. This study aimed to conduct a comprehensive review in order to present current knowledge on benzene biomarkers and their significance in evaluating exposure levels and associated health hazards. The search methodology adhered to the PRISMA guidelines and involved the application of specific inclusion and exclusion criteria across multiple databases including PubMed, Embase, and Web of Science. Two researchers independently extracted and evaluated the relevant data based on predetermined criteria. Following the screening process, a total of 80 articles were considered eligible out of the initially retrieved 1053 articles after undergoing screening and assessment for inclusion. As the level of exposure decreased, specific biomarkers demonstrated a gradual increase in limitations, including heightened background concentrations and vulnerability to confounding factors. The advancement of sampling and analysis techniques will yield new biomarkers. Additionally, when conducting practical work, it is crucial to employ a comprehensive utilization of diverse biomarkers while excluding individual metabolic variations and combined exposure factors.
Helicopter vibration control employing superelastic pitch link with shape memory alloy
Authors: Oliveira Andersson Guimarães , Silva Antônio Almeida , Rodrigues Marcelo Cavalcanti , Dantas Grassi Estephanie Nobre , de Araújo Carlos José , Batista do Reis Romulo Pierre 
Published: June 2024

One of the main applications of shape memory alloy (SMA) concerns vibration control, especially superelastic SMA (SMA-SE), which presents a significant stress hysteresis and can work as a damper while adding minimal weight to the structure. In helicopters, vibration is a phenomenon inherent to their operation, and although cannot be eliminated, must be minimized to acceptable levels of safety and comfort. In this context, this paper aims to present the design, testing, and dynamic behavior of a new device entitled smart pitch link, a device with superelastic material for passive vibration control. The paper depicts the design process, assembly, and device testing using a whirl tower that simulates a helicopter rotor in hover. The approach adopts a comparative analysis of the dynamic response on the prototype in reference condition, with a stiff pitch link, with the modified prototype, and with the superelastic pitch link installation. In addition, beyond hover tests, cyclic commands and an asymmetrical lateral gust were employed to observe the output response of the device under transient loadings. Contrary to the literature data about the low time response of SMA, the device presents satisfactory time response and attenuation in frequencies close to main rotor frequencies, with signal attenuations between 2 to 4 dB without any external energy consumption, which, in a comparative analysis, may exceed more than 50% of vibrational amplitude attenuation.
Maximizing the Effectiveness of Anti-Smoking Campaigns With Targeted Framing Strategies: Evidence From Behavioral and Neurological Studies
Authors: Ghods Hadi , Aghayari Mehrdad , Golbazi Mahdipour Ali , Arabi Zanjani Reza , Aghayari Hanieh , Soparnot Richard , Bonyadi Naeini Ali 
Published: June 2024

Background The global prevalence of smoking remains a significant public health concern, necessitating the development of effective anti-smoking campaigns to promote smoking cessation and discourage smoking initiation. Understanding the factors that influence individual responses to anti-smoking messages is critical for tailoring campaigns to different populations. Focus of the Article This study substantially exhibits the concepts of audience segmentation and targeting, informed by theory and formative research, and monitoring and evaluation research in the context of anti-smoking campaigns. Research Question The article aims to answer how smoking behavior and message framing influence individuals’ counterarguing responses to anti-smoking advertisements and the implications for ad effectiveness. Approach The research investigates the role of smoking behavior (smokers vs. non-smokers) and message framing (positive vs. negative) in shaping individuals’ counterarguing responses to anti-smoking advertisements, using two studies involving behavioral and neuroscientific methods. Methods Study 1 employed an online video task with 1920 participants, examining the effects of smoking behavior and message framing on ad effectiveness. Study 2 used electroencephalography (EEG) to record brain activity from 31 participants while they viewed anti-smoking video advertisements, focusing on the neural correlates of counterarguing and their effect on anti-smoking ad effectiveness. Results Study 1 found that smokers report lower ad effectiveness compared to non-smokers, and observed an interaction between smoking behavior and message framing. Study 2 found that smoking behavior significantly influenced brain activity in the dorsolateral prefrontal cortex (dlPFC), ventrolateral prefrontal cortex (VLPFC), and anterior cingulate cortex (ACC) regions in response to anti-smoking ads. Additionally, a significant interaction was observed between smoking behavior and ad framing on brain activity in all three regions. Recommendations for Research or Practice The findings suggest that anti-smoking campaigns should be tailored to the specific needs and attitudes of smokers and non-smokers, with separate campaigns for each group. Future research could explore the role of other individual differences in shaping counterarguing responses, the long-term effects of exposure to different types of anti-smoking messages on smoking behavior, and using more advanced neuroimaging techniques to investigate the neural processes that underlie counterarguing responses to anti-smoking messages for better flow.
Antimalarial Studies and Phytochemical Profiling of Laportea aestuans (L.) Chew Extractives
Authors: Faloye Kolade O. , Oguntimehin Samuel A. , Adesida Stephen A. , Olufolabo Katherine O. , Bello Oyenike I. , Oguntimehin Israel A. , Ugwo Jeremiah P. , Babaagba Tolulope B. , Okunribido Blessing I. , Aladesanmi Joseph A. 
Published: June 2024

Background and objectives This study validated the antimalarial efficacy of Laportea aestuans extract using chemosuppressive and curative models, identified its most active fraction, and performed chemical profiling of the active fraction. Methodology The aerial part of L. aestuans (LA) was extracted with 80% methanol and assayed for its chemosuppressive and curative antimalarial activities through the oral administration of the extract (100, 200, 400 and 800 mg/kg) to groups consisting of five mice each. The extract was thereafter suspended in water and partitioned with dichloromethane to afford the dichloromethane (DLA) and aqueous (ALA) fractions. The fractions (10, 20, 40, and 80 mg/kg) were thereafter tested for their antimalarial activity followed by GC-MS analysis of the most active fraction. Results The toxicity level was found to be above 2000 mg/kg. The activity recorded for the four-day chemosuppressive antimalarial tests showed a dose-dependent activity up to 400 mg/kg. The activity was significantly lower than that of chloroquine. The antimalarial activity of the extract at the lowest dose of 100 mg/kg was 42%. In the curative test, the extract of LA gave a dose-dependent activity that was significantly higher than the negative control. The DLA and ALA fractions gave a comparable curative activity across all doses. At 10 mg/kg, ALA and DLA gave percentage clearance of 81.25 ± 1.84 and 87.45 ± 1.35, respectively, which were significantly higher than that of the negative control (0.00 ± 0.00) and significantly lower than that of the positive control (94.93 ± 0.26). The chemical profiling revealed the presence of non-polar and medium-polar constituents in the dichloromethane fraction. Conclusion The good antimalarial activity elicited by LA extractives supports its usage in ethnomedicine as an antimalarial agent.
Effects of High-Velocity Versus Low-Velocity Resistance Training on Muscle Echo Intensity in Healthy Young Women: A Randomized Controlled Trial
Authors: Wang Zimin , Taniguchi Masashi , Saeki Junya , Ichihashi Noriaki 
Published: June 2024

Background: Improving muscle quality to prevent and treat muscle dysfunction is critical. However, effective measures to improve muscle quality remain poorly understood. We investigated the effects of high- and low-velocity resistance training (RT) on muscle quality, mass, and function before and after an 8-week intervention. Hypothesis: High-velocity RT would improve muscle quality more effectively than low-velocity RT. Study Design: Randomized controlled trial. Level of Evidence: Level 1. Methods: A total of 33 healthy young women (23.1 ± 2.2 years) were assigned randomly to high-velocity (n = 16) or low-velocity (n = 17) groups. Both groups underwent concentric knee extension RT with a 60% 1-repetition maximum (1RM) load, performing 10 repetitions of 4 sets, 3 times per week for 8 weeks. The high-velocity group was instructed to complete each repetition as quickly as possible (mean repetition duration of 0.5 seconds), while the low-velocity group was required to execute each repetition in 3 seconds. Before and after the 8-week intervention, quadriceps femoris echo intensity (EI), muscle thickness (MT), isokinetic peak torque (60 and 300 deg/s), rate of velocity development (RVD) at 300 deg/s, and 1RM were assessed. Split-plot factorial design analysis of variance was used to compare the group × time interaction. Results: A group×time interaction was observed for EI ( P < 0.01). Only the high-velocity group showed a significant reduction in EI after the intervention. MT revealed a main effect of time ( P < 0.01), with both groups significantly increasing MT. RVD showed a group × time interaction ( P < 0.05), with significant increase only in the high-velocity group. Isokinetic peak torque and 1RM showed main effects of time ( P < 0.01), with significant increases in both groups. Conclusion: High-velocity RT may be superior to low-velocity RT in enhancing muscle quality and RVD. Clinical Relevance: These results emphasize the importance of RT velocity for muscle quality improvement.
Segmental Spinal Aplasia: Anatomical Variations and Treatment Insights
Authors: Sergeenko Pavlova Olga M. , Savin Dmitry M. , Burtsev Alexander V. , Saifutdinov Marat S. , Ryabykh Sergey O. , Evsyukov Alexey V. 
Published: June 2024

Study Design Retrospective Cohort Study. Objective The study aimed to analyze anatomical variants of segmental spinal aplasia (SSA) and investigate factors influencing surgical treatment outcomes, with a specific focus on the incidence of complications. Methods The study focused on patients with SSA treated at a single medical center, with over two years of follow-up. Neurological function changes were evaluated using the modified Japanese Orthopedic Scale (mJOA). Functional independence was measured using the Functional Independence Measure (FIM/WeeFIM) scale, and complications, well-being, and reoperation instances were documented. Statistical analyses used ANOVA and Kruskal-Wallis test. Results The predominant localization of SSA in 36 own cases occurs near or at the level of the thoracolumbar junction, often accompanied by significant spinal cord narrowing and a low position of the conus medullaris. Additionally, it frequently presents with aplasia of the lower ribs. Cervicothoracic SSA was more commonly associated with segmentation disorders ( P = .04). The most common early complications were wound problems (17%) and neurological deterioration (17%); the most common late complications were: non-fusion (34%); 38% of patients required one or more revision surgery. The type, age of surgery, level of surgery, and initial neurological deficient did not significantly influence the incidence of complications or neurological and functional outcomes. Conclusion SSA, a range of anomalies appearing early in childhood, progresses gradually. Surgery involves vertebrectomy followed by interbody fusion and screw fixation, guided by neurophysiological monitoring. Surgery is recommended for worsening neurological symptoms, but conservative options like bracing can be considered, due to a high risk of complications.
Identifying therapeutic target genes for migraine by systematic druggable genome-wide Mendelian randomization
Authors: Zhang Chengcheng , He Yiwei , Liu Lu 
Published: June 2024

Abstract
Background
Currently, the treatment and prevention of migraine remain highly challenging. Mendelian randomization (MR) has been widely used to explore novel therapeutic targets. Therefore, we performed a systematic druggable genome-wide MR to explore the potential therapeutic targets for migraine.

Methods
We obtained data on druggable genes and screened for genes within brain expression quantitative trait locis (eQTLs) and blood eQTLs, which were then subjected to two-sample MR analysis and colocalization analysis with migraine genome-wide association studies data to identify genes highly associated with migraine. In addition, phenome-wide research, enrichment analysis, protein network construction, drug prediction, and molecular docking were performed to provide valuable guidance for the development of more effective and targeted therapeutic drugs.

Results
We identified 21 druggable genes significantly associated with migraine (BRPF3, CBFB, CDK4, CHD4, DDIT4, EP300, EPHA5, FGFRL1, FXN, HMGCR, HVCN1, KCNK5, MRGPRE, NLGN2, NR1D1, PLXNB1, TGFB1, TGFB3, THRA, TLN1 and TP53), two of which were significant in both blood and brain (HMGCR and TGFB3). The results of phenome-wide research showed that HMGCR was highly correlated with low-density lipoprotein, and TGFB3 was primarily associated with insulin-like growth factor 1 levels.

Conclusions
This study utilized MR and colocalization analysis to identify 21 potential drug targets for migraine, two of which were significant in both blood and brain. These findings provide promising leads for more effective migraine treatments, potentially reducing drug development costs.