bluuebunny/crossref_metadata_2025_split huggingface dataset:
The relationship between retinal hemodynamics and systemic markers of endothelial function and inflammation in type 2 diabetes
Authors: HUDSON C , KHUU LA , PALKA E , FLANAGAN JG , WONG T , LAM WC , MARKOWITZ SN , BRENT M , MANDELCORN M , DEVENYI RG 
Published: September 2009

Abstract Purpose The aim of the study was to investigate the associations, if any, between retinal hemodynamics and systemic markers of endothelial function and inflammation in patients with type 2 diabetes and non‐proliferative diabetic retinopathy (NPDR). Methods Retinal blood flow measurements and blood serum samples were obtained from 9 healthy controls (Group 1, mean age 53.8 yrs, SD 11.7), 23 patients with mild‐to‐moderate NPDR (Group 2, mean age 61.4 yrs, SD 8.5; duration 9.9 yrs, SD 8.8) and 14 patients with moderate‐to‐severe NPDR (Group 3, mean age 60.3 yrs, SD 9.9; duration 17.0 yrs, SD 9.4). Retinal blood flow was measured in the supero‐temporal arteriole using the Canon Laser Blood Flowmeter. Blood samples were collected to derive levels of intercellular adhesion molecule (ICAM‐1), vascular adhesion molecule (VCAM‐1), E‐selectin and von Willebrand factor (vWF). Results Diameter, velocity, maximum‐to‐minimum velocity ratio and flow were the same across the groups and did not change over a 6 month follow‐up. A1c and ICAM‐1 were significantly elevated across the groups (p=0.001 and p=0.030, resp., ANOVA). VCAM‐1 (r =0.325, p=0.046) and vWF (r =0.334, p=0.050) showed relatively weak associations with baseline max:min velocity ratio. vWF showed moderate associations with change in velocity (r = 0.571, p=0.007) and change blood flow (r = 0.455, p=0.038). Conclusion The relationship between endothelial dysfunction and inflammation markers and retinal hemodynamics in type 2 diabetes is complex since not all markers show an association. This work is on‐going.
The Boston keratoprosthesis in autoimmune disease
Authors: CHODOSH J 
Published: September 2009

Abstract Purpose Patients with corneal blindness due to mucous membrane pemphigoid and Stevens Johnson syndrome who undergo corneal transplantation carry a poor prognosis for visual recovery. The Boston keratoprosthesis has been demonstrated to provide excellent retention rates and postoperative visual acuity in patients with corneal graft failure, however, poor visual outcomes still occur in patients with underlying autoimmune disease. Methods We reviewed the current literature to determine the results of keratoprosthesis in patients with blinding autoimmune diseases. Results Much of the published literature on keratoprosthesis fails to clearly differentiate outcomes on the basis of the underlying disorder. Based on available evidence, inflammation, retinal detachment, and glaucoma appear to be the most significant complications after keratoprosthesis in autoimmune patients, and a diagnosis of mucous membrane pemphigoid or Stevens Johnson Syndrome appears to be associated with a significantly higher complication rate than other preoperative conditions. Conclusion Patients with autoimmune diseases carry the worst prognosis for success with keratoprosthesis. Improvement in clinical outcomes might be achieved with changes in keratoprosthesis design and material, perioperative therapy, and/or surgical technique. Possible approaches to complications after Boston keratoprosthesis in patients with underlying autoimmune diseases will be discussed.
Long‐term functional and anatomical results of OOKP and tibial OKP: Barcelona experience
Authors: DE LA PAZ MF , BARRAQUER J 
Published: September 2009

Abstract Purpose To report the long‐term functional and anatomical results of OOKP and Tibial OKP performed at the Barraquer Eye Center from 1974‐2006. Different factors like surgical technique, clinical diagnosis, age and post‐operative complications are also analyzed and reported. Methods A retrospective study on 330 eyes of 227 patients who underwent OOKP or tibia OKP was performed. Kaplan Meier survival curves and multivariate analysis using Cox regression model of the different variables mentioned are presented. Results OOKP and Tibia OKP have comparable functional and anatomical results in the long‐term. Best long‐term functional and anatomical results are for patients with chemical burns, cicatricial trachoma and Stevens‐Johnsons/Lyell syndrome. Thermal burns have a higher anatomical retention than other diagnostic categories. Younger patients have better visual prognosis and anatomical retention than older patients. Patients must be warned of the possibility of sight‐threatening complications like extrusion of the prosthesis, retinal detachment and glaucoma. Conclusion Our more than 35 years experience with biological keratoprosthesis using the OOKP and the tibia OKP shows that the two techniques are comparable. Certain variables like clinical diagnosis, age and post‐operative complications affect the anatomical and functional results in the long‐term.
Tibial KPro
Authors: TEMPRANO J 
Published: September 2009

AbstractThe clinical results, from the anatomical point of view, are very good, although in the cases of mucosynechial syndromes, which also affect the buccal mucosa, pemphigoids or necrolysing epidermosis (Lyell), the mucosa may retract or necrolyse. In these cases we use the transtarsal method. In elderly patients with osteoporosis the bone may be resorbed and it would be necessary to repeat the procedure using bone from a more favorable area of the tibia, which should be determined with local densitometry. As far as the functional results are concerned, these depend on the conditions of the retina and the optic nerve. If both are in good conditions and the ocular pressure is normal, 20/20 vision may be achieved, although the visual field will never be more then 30º maximum. Indications: We perform this type of keratoprosthesis in patients without suitable teeth, affected with: Physical caustications (metal burns, bomb explosions, fire burns, etc.) Chemical caustications, no matter whether the origin be alkali (worse prognosis because of the glaucoma which usually develops in these cases) or acids (lime, sulphuric acid, sodium hydroxide, etc). Important trauma where the eye had to be covered with skin because of extensive lid destruction. Advanced trachoma with total leucoma and extensive vascularization. Pemphigus and all mucosynechial syndromes which lead to total xerosis Lyell’s syndrome, epidermizing necrolysis Cases of repeated failure of corneal transplantations Anterior segment alterations due to complicated aphakia, bullous keratopathy affecting the entire cornea after previous failure of keratoplasty. Generally, total leucoma with important alterations of the limbus which would not permit survival of a corneal homotransplant.
MOOKP clinical results and Indications
Authors: FALCINELLI G 
Published: September 2009

Abstract Purpose To demonstrate which are the reasons that permit by the modified osteo‐odonto‐keratoprosthesis (Mookp) technique to obtain in 275 blind eyes,with a basic pathology where 42% of eyes were dry,and 32% had severe physical/chemical burns,excellent anatomical and functional results. Methods Tables are shown which put into evidence the best visual acuity obtained in the 275 eyes affected by corneal blindness,operated by the Mookp technique from 1973 to 2008, with a 36 years causistry,with a very long follow‐up. Results 275 blind eyes. Best Visual Acuity recovered, between 10/10 and 5/10 in 80.25% of operated eyes, excellent for any working activity,( best visual acuity recovered), between 10/10 and 2/10 in 91,20%, useful for any activity. Final V.A., between 10/10 and 5/10 in 67,68%, and between 10/10 and 2/10 in 78,11%‐ Conclusion The reasons for these excellent results are due to the biological properties of this Kpro invented by Strampelli and to the modifications made by Falcinelli. The indications for this technique are all those types of corneal blindness not treatable by penetrating keratoplasty.
Intravitreal bevacizumab for neovascular age‐related macular degeneration: twelve months of follow up
Authors: EL MATRI L , BAKLOUTI K , BOURAOUI R , KORT F , LIMAIEM R , BEN YOUSSEF N , LANDOULSI H 
Published: September 2009

Abstract Purpose To evaluate the efficacy and safety of intravitreal bevacizumab for managing choroidal neovascularization (CNV) due to age‐related macular degeneration (AMD) at one‐year of follow‐up. Methods A retrospective review of all patients treated with intravitreal bevacizumab (1.25mg in 0.05ml) for subfoveal or juxtafoveal CNV from AMD between June 2006 and December 2008. The files were reviewed for background data, visual acuity, fluorescein angiography, central retinal thickness and complications. Patients received injections every 4 to 6 weeks until resolution of CNV activity. Results A total of 72 eyes of 67 patients were treated. Mean follow‐up was 14.1 months (range 11 to 16 months). Twenty seven percent of patients had undergone previous PDT treatment for CNV. The mean number of injections was 2.9. The mean best corrected visual acuity was 1.06 logMAR (range 2 – 0.1 logMAR) at baseline and improved to 0.9 logMAR (range 2‐ 0.2 logMAR) at the last visit. The mean central retinal thickness was 404µm (range 191 – 1070 microns) at baseline and decreased to 279.9µm (range 140‐ 620µm) at 14‐months follow‐up. Statistically significant differences were found in visual acuity (p=0.044) and central retinal thickness (p=0.01) before and after intravitreal injections. No significant ocular or systemic side effects were observed. Conclusion Our results suggest that intravitreal bevacizumab is well tolerated and is associated with improvement in visual acuity and decrease in retinal thickness at 12 months of follow‐up. Further controlled, prospective and long term evaluation of this treatment is warranted.
Can preoperative bevacizumab improve trabeculectomy outcome? Avastin‐Trab study
Authors: VANDEWALLE E 
Published: September 2009

Abstract Purpose The aim of this project is to study whether peroperative intracameral bevacizumab (Avastin®) might improve the outcome of filtration surgery. Methods This study will be carried out in a prospective, placebo‐controlled, double‐blinded experimental setup. The effect of peroperative administration of bevacizumab on intraocular pressure, bleb characteristics and post‐operative medication and surgical intervention will be investigated. The risk of systemic side‐effects will minimalized by using local anti‐Vascular Endothelial Growth Factor treatment. The study patients will be divided into two major groups: A) Patients with primary open angele glaucoma and B) Patients with normotensive glaucoma, in which very low IOPs are targeted. Both groups of patients will undergo a trabeculectomy. Patients in group A will not be given the antimetabolite Mitomycin C (MMC), while patients in group B will receive MMC to obtain sufficiently low IOPs. This strategy adheres to standard operating procedures for filtration surgery. Results will follow Conclusion Our study will potentially shed new light on a plausible and simple method to improve the prognosis of glaucoma filtration surgery. Since this study will provide direct data on the effectiveness of a one‐time treatment that might reduce the risk of bleb failure after filtration surgery, avoiding or reducing the need for long‐term medication use or secondary surgical intervention, the potential clinical implications of this study are clear. Thus, our project opens exciting new perspectives for the treatment and prognosis of the blinding condition of glaucoma
Is neuroglobin (Ngb) a perspective for glaucoma?
Authors: YOU Y 
Published: September 2009

Abstract Purpose To further explore the mechanisms of Ngb function in the retina, and investigate the possible neuroprotective potency of this O2‐binding protein in glaucoma. Our project will potentially open exciting perspectives for the treatment and prognosis of the blinding condition of glaucoma. Methods 1) In vitro: We will set up cultures for primary RGCs. The cultured RGCs will be subjected to hypoxia by incubation in a controlled‐atmosphere incubator. Cell survival and apoptosis will be assessed using MTT method and TUNEL staining. Ngb expression in normoxic and hypoxic cells will be compared. Additionally, the RGCs will be transfected with plasmids expressing Ngb mRNA to evaluate the neuroprotective effect of Ngb. 2) In vivo: The ischemia/reperfusion model and the staurosporine intravitreal injection model cause acute RGC loss. We will also use a laser model to induce chronic elevated IOP by obstructing the aqueous outflow pathway. We will first analyze upregulated Ngb expression in these models. The localization of both Ngb mRNA and protein will be assessed. Ngb‐Tg mice will be subjected to the glaucoma models. We will measure cell density or retinal thickness and perform electroretinography to evaluate the physiological function of retina. We will also analyse the possible contribution of oxidative stress via immunostainings for ROS and determine possible effects on NO scavenging by evaluating the expression of NOS. Furthermore, we will transfect RGCs in vivo using intravitreal injections of a Ngb expressing adeno‐associated virus (AAV) to test the therapeutic potential of Ngb. Conclusion Our project will not only provide us with an improved understanding of neuroglobin, but also open a new perspective for the treatment of retinal ganglion cell apoptosis and glaucomatous neuropathy.
Micro‐incision (MICS), perfecting wound incision
Authors: COCHENER B 
Published: September 2009

AbstractIt is nowadays well admitted that a perfect incision in microincision (means size inferior to 2 mm) is crucial: for easy manipulation in the eye, anterior chamber stability during surgery, self sealing without suture and no induced astigmatism. This presentation will focus on incision architecture including location, size, shape and self sealing. We will provide some practical tips and tricks for performing a corneal incision as perfect as possible, which is the key for a successful MICS, whatever a bimanual (B‐MICS) or coaxial approach (C‐MICS).
MICS, mastering the critical steps
Authors: BELLUCCI R 
Published: September 2009

AbstractAlthough every manoeuvre has to be modified for MICS, there are some more critical steps. Capsulorhexis through 1.8 mm incision requires a dedicated forceps, usually coaxial, that should be appropriately managed. However it is easier than capsulorhexis through larger incision, because of the improved visibility and chamber stability. The fluidics control of MICS is also different from that of standard phacoemulsification, and includes low hysteresis of the system, reduced fluid volumen, dual control of vacuum and ultrasound, and the removal of lens particles from the aspiration line. With this “microfluidics” of phacoemulsification there is no need to increase the bottle height above 90 cm.
18 years experience of the use of proton beam in ophthalmic tumours
Authors: DESJARDINS L , LUMBROSO‐LE ROUIC L , LEVY C , PLANCHER C , ASSELAIN B , DELACROIX S , DENDALE R 
Published: September 2009

Abstract Purpose Since 1991, more than 3000 patients were treated at Curie Institute by proton beam for uveal melanoma. All datas concerning tumor characteristics, treatment planning and follow up are registered in the data base Methods We have performed a retrospective review of patients treated before 2005. Patients were sent to Curie by their local ophtalmologist. Clip positioning and proton beam therapy with a dose of 60 grays in 4 fractions was scheduled; All patients were seen once a year in our clinic after treatment with liver ultrasounds twice a year. Results 2214 patients were treated, median age 61 years, median diameter 13,6 mm, median Thickness 4,7 mm. 20% of patients develloped metastasis,25% of patients died, 4% had local recurrences, 6,7% had secondary enucleations; With multivariate analysis Significant risk factors for metastasis were age (>60 ), tumor location, tumor diameter and tumor thickness( p<0,0001); Significant risk factor for local recurrence was tumor diameter (p<0,001) significant risk factor for secondary enucleation were tumor diameter (p<0,0001) and tumor thickness (p= 0,003) Neovascular glaucoma was 10% at 2years , 30% at 5 years and 34% at 10 years. Maculopathy was 40% at 2 years, 62% at 5 years and 66% at 10 years Optic neuropathy was 14% at 2 years, 29% at 5 years and 38% at 10 years At last follow up 36,2% of patients have more than 20/40 vision Conclusion Tumor control obtained by proton beam is excellent with a long follow up For big tumors news additional techniques like endoresections, additional TTT or antiVEGF could enhance globe preservation
The use of ruthenium plaque brachytherapy in retinoblastoma
Authors: ABOUZEID H , MOECKLI R , GAILLARD MC , BECK‐POPOVIC M , PICCA A , ZOGRAFOS L , BALMER A , PAMPALLONA S , MUNIER F 
Published: September 2009

Abstract Purpose To evaluate the efficacy of 106Ru plaque brachytherapy for the treatment of retinoblastoma. Methods We reviewed a retrospective, noncomparative case series of 39 children with retinoblastoma treated with 106Ru plaques at the Jules‐Gonin Eye Hospital between October 1992 and July 2006, with 12 months of follow‐up. Results A total of 63 tumors were treated with 106Ru brachytherapy in 41 eyes. The median patient age was 27 months. 106Ru brachytherapy was the first‐line treatment for 3 tumors (4.8%), second‐line treatment for 13 (20.6%), and salvage treatment for 47 tumors (74.6%) resistant to other treatment modalities. Overall tumor control was achieved in 73% at 1 year. Tumor recurrence at 12 months was observed in 2 (12.5%) of 16 tumors for which 106Ru brachytherapy was used as the first‐ or second‐line treatment and in 15 (31.9%) of 47 tumors for which 106Ru brachytherapy was used as salvage treatment. Eye retention was achieved in 76% of cases (31 of 41 eyes). Univariate and multivariate analyses revealed no statistically significant risk factors for tumor recurrence. Radiation complications included retinal detachment in 7 (17.1%), proliferative retinopathy in 1 (2.4%), and subcapsular cataract in 4 (9.7%) of 41 eyes. Conclusion 106Ru brachytherapy is an effective treatment for retinoblastoma, with few secondary complications.Local vitreous seeding can be successfully treated with 106Ru brachytherapy.
Comparison of corneal thickness, anterior segment depth and pupil diameter between patients with neovascular age‐related macular degeneration and controls
Authors: PAHOR D , KNEZ N , SISKO K 
Published: September 2009

Abstract Purpose The goal of this study was firstly to compare corneal thickness at four different locations, anterior depth and pupil diameter between patients with neovascular age‐related macular degeneration and healthy individuals and secondly, to find out any possible anterior segment related risk factor for AMD development. Methods In this prospective study 69 patients (119 eyes) with neovascular age‐related macular degeneration with no history of any ocular disease or surgery were included. The 31 controls (56 eyes) were also enrolled. Informed consent was obtained from all recruited individuals. Each subject underwent complete ophthalmic examination. Galilei Dual Scheimpflug Analyzer (version 3.0, Ziemer Ophthalmic Systems AG, Switzerland), a non‐invasive diagnostic system designed for analysis of anterior chamber of the eye, was used for anterior segment evaluation. Results Comparison of corneal thickness at central, paracentral, peripheral zone and at the thinnest point revealed no statistically important difference between patients with age‐related macular degeneration and controls (P<0,5). There was a statistically significant difference in the mean anterior chamber depth between both groups (P=0,002). We did not observe statistically important difference in pupil diameter between both group (P>0,5). Conclusion The results of our study confirmed that the corneal thickness and pupil diameter are not associated with age‐related macular degeneration. Further investigations are necessary to confirm our results and to find out a possible role of anterior chamber depth as an additional risk factor for AMD development.
Repeatability in the measurement of macular pigment optical density using the Metropsis Test.
Authors: PEREZ CARRASCO MJ , BARRIO AR , PALOMO C , PUELL MC 
Published: September 2009

Abstract Purpose This study was designed to report the reproducibility of macular pigment optical density (MPOD) assessed with the Metropsis Test. Methods In two separate sessions, we measured macular pigment (MP) optical density at the fovea in 22 healthy young subjects (21.4 ± 2.26 mean age) with the Metropsis Test (Cambridge Research Systems) that is based in the apparent motion photometry method and employs a CRT monitor for stimulus presentation. The reliability was estimated by the Bland‐Altman statistical method and Student’s t‐test for paired data. The factors determined were mean difference and the coefficient of repeatability (COR = 1.96 x SD). Results The mean MPOD in right eyes at the first visit was 0.347 ± 0.20 and 0.348 ± 0.25 at the second. The mean difference between sessions was ‐0.0009 ± 0.183 without statistical significance (p < 0.382); and with a normal distribution. The coefficient of repeatability was ± 0.358. Conclusion The mean difference of MPOD values was practically zero, but if we keep in mind the ends of the interval we must conclude that Metropsis Test presents a moderate repeatability in the measurement of macular pigment optical density.
Spectral domain OCT of exudative AMD
Authors: LEVEZIEL N , VOIGT M , COSCAS G , SOUBRANE G 
Published: September 2009

AbstractAge‐related Macular Degeneration (AMD) is the main cause of vision loss in developed countries. Spectral domain OCT (SD‐OCT) is a non invasive technique providing in vivo imaging of the retina, with a higher resolution than time domain OCT. This SIS will describe the clinical features of exudative AMD with SD‐OCT, including occult choroidal neovascularization (CNV), classic CNV, idiopathic polypoïdal vasculopathy, and chorioretinal anastomosis. The improvement of the resolution of retinal imaging will provide a better classification and explanation of the pathological processes observed during AMD.
Chorioretinal anastomosis in adaptive optic and high definition spectral domain optical coherence tomography
Authors: MAILLON C , VOIGT M , COSCAS G , SOUBRANE G 
Published: September 2009

Abstract Purpose To assess morphologic variations in the outer and inner retinal layers in eyes with chorioretinal anatomosis using high definition Spectral Domain Optical Coherence Tomography (Spectralis HRA OCT, Heidelberg Engineering, Heidelberg, Germany) and to compare these scans with images acquired by Adaptive Optics (AO). Methods This was a prospective observational case series including 50 patients. SD‐OCT scans were obtained with combined confocal scanning laser ophthalmoscope (cSLO) and SD‐OCT for simultaneous tomographic and topographic in vivo imaging. Patients underwent fluorescein and ICG‐ angiography and Adaptive Optics assessment with Imagine Eyes™ System. The neurosensory retina and the photoreceptor layer were analyzed using both HR‐OCT and AO imaging. Results Combining of the adaptive optics with SD‐OCT may give us further information of the early stage development of chorioretinal anastomosis.