bluuebunny/crossref_metadata_2025_split huggingface dataset:
How effective is nutrition training for staff running after school programs in improving quality of food purchased and meal practices? A program evaluation
Authors: Beinert Cecilie , Røed Margrethe , Vik Frøydis N. 
Published: May 2024

Abstract
Objectives / purpose
After school programs represents a setting for promoting healthy dietary habits. The aim of this study was to evaluate how effective the after school program staff perceived nutrition training aiming to improve quality of food purchased and meal practices. We further aimed to assess the changes in purchase of primarily fish and fish products, whole grains and fruit and vegetables, by collecting receipts from food purchase before and after the intervention.

Results
This is a mixed methods study. Group interviews with after school staff were carried out and the data was analyzed deductively according to the RE-AIM framework. Receipts from food purchase were collected. Findings from the qualitative interviews indicated that the intervention had been a positive experience for the staff and suggested a new way of working with promoting healthy foods in after school program units. Although there were some challenges reported, the staff made necessary adjustments to make the changes possible to sustain over time. Findings from the receipts support the changes reported by the staff. These showed increased purchase of vegetables, fish, and whole grain in all four after school program units. After school programs in similar settings may expand on these findings to improve the students’ dietary habits.
Use of digital media by adolescents for sexual and reproductive health and rights communication in sub-Saharan Africa: a protocol for systematic review
Authors: Ackah Josephine Akua , Esia-Donkoh Kobina , Amponsah Antoinette P. , Agbemavi Wonder , Bediako Vincent Bio , Tettey Gloria N. A. 
Published: May 2024

Abstract
Background
Within the sub-Saharan African region, there is a growing concern for sexual and reproductive health and rights communication, and more particularly, for adolescents. Given the existing barriers associated with face-to-face access, the need to use digital media to access information and services has become desirable and imperative, especially so due to the COVID-19 pandemic. However, in sub-Saharan Africa, a synthesis of evidence that informs adolescents’ digital media engagements for sexual and reproductive health and rights (SRHR) communication is limited. This systematic review therefore aims to examine and synthesize evidence on use of digital media for sexual and reproductive health and rights communication by adolescents in sub-Saharan Africa.

Methods
A search for peer-reviewed articles will be conducted in PubMed, ScienceDirect, Scopus, Embase, Web of Science, PsychINFO and Google Scholar with emphasis on those published between 2000 and 2023. Only observational and qualitative studies will be included. Quality assessment of included articles will be done using standardized checklists from the Joanna Briggs Institute. Both descriptive and narrative summaries will be used to appraise evidence from included studies.

Discussion
This review will be essential in providing information on the types of digital media adolescents use, the various SRHR issues they use this platform to address and their reasons for using it and associated challenges. It will also contribute to the advocacy for the inclusion of these technologies in the teaching and learning, provision of and access to SRHR information and services by teachers, public health providers and peer educators in the subregion.

Systematic review registration
PROSPERO CRD42020211491. This protocol follows the PRISMA-P guidelines for reporting systematic reviews.
Protocol for a scoping review study on learning plan use in undergraduate medical education
Authors: Romanova Anna , Touchie Claire , Ruller Sydney , Cole Victoria , Humphrey-Murto Susan 
Published: May 2024

Abstract
Background
The current paradigm of competency-based medical education and learner-centredness requires learners to take an active role in their training. However, deliberate and planned continual assessment and performance improvement is hindered by the fragmented nature of many medical training programs. Attempts to bridge this continuity gap between supervision and feedback through learner handover have been controversial. Learning plans are an alternate educational tool that helps trainees identify their learning needs and facilitate longitudinal assessment by providing supervisors with a roadmap of their goals. Informed by self-regulated learning theory, learning plans may be the answer to track trainees’ progress along their learning trajectory. The purpose of this study is to summarise the literature regarding learning plan use specifically in undergraduate medical education and explore the student’s role in all stages of learning plan development and implementation.

Methods
Following Arksey and O’Malley’s framework, a scoping review will be conducted to explore the use of learning plans in undergraduate medical education. Literature searches will be conducted using multiple databases by a librarian with expertise in scoping reviews. Through an iterative process, inclusion and exclusion criteria will be developed and a data extraction form refined. Data will be analysed using quantitative and qualitative content analyses.

Discussion
By summarising the literature on learning plan use in undergraduate medical education, this study aims to better understand how to support self-regulated learning in undergraduate medical education. The results from this project will inform future scholarly work in competency-based medical education at the undergraduate level and have implications for improving feedback and supporting learners at all levels of competence.

Scoping review registration:
Open Science Framework osf.io/wvzbx.
Recognizing online video genres using ensemble deep convolutional learning for digital media service management
Authors: Shao Yuwen , Guo Na 
Published: May 2024

AbstractIt's evident that streaming services increasingly seek to automate the generation of film genres, a factor profoundly shaping a film's structure and target audience. Integrating a hybrid convolutional network into service management emerges as a valuable technique for discerning various video formats. This innovative approach not only categorizes video content but also facilitates personalized recommendations, content filtering, and targeted advertising. Given the tendency of films to blend elements from multiple genres, there is a growing demand for a real-time video classification system integrated with social media networks. Leveraging deep learning, we introduce a novel architecture for identifying and categorizing video film genres. Our approach utilizes an ensemble gated recurrent unit (ensGRU) neural network, effectively analyzing motion, spatial information, and temporal relationships. Additionally,w we present a sophisticated deep neural network incorporating the recommended GRU for video genre classification. The adoption of a dual-model strategy allows the network to capture robust video representations, leading to exceptional performance in multi-class movie classification. Evaluations conducted on well-known datasets, such as the LMTD dataset, consistently demonstrate the high performance of the proposed GRU model. This integrated model effectively extracts and learns features related to motion, spatial location, and temporal dynamics. Furthermore, the effectiveness of the proposed technique is validated using an engine block assembly dataset. Following the implementation of the enhanced architecture, the movie genre categorization system exhibits substantial improvements on the LMTD dataset, outperforming advanced models while requiring less computing power. With an impressive F1 score of 0.9102 and an accuracy rate of 94.4%, the recommended model consistently delivers outstanding results. Comparative evaluations underscore the accuracy and effectiveness of our proposed model in accurately identifying and classifying video genres, effectively extracting contextual information from video descriptors. Additionally, by integrating edge processing capabilities, our system achieves optimal real-time video processing and analysis, further enhancing its performance and relevance in dynamic media environments.
Endotyping in ARDS: one step forward in precision medicine
Authors: Côté Andréanne , Lee Chel Hee , Metwaly Sayed M. , Doig Christopher J. , Andonegui Graciela , Yipp Bryan G. , Parhar Ken Kuljit S. , Winston Brent W. 
Published: May 2024

Abstract
Background
The Berlin definition of acute respiratory distress syndrome (ARDS) includes only clinical characteristics. Understanding unique patient pathobiology may allow personalized treatment. We aimed to define and describe ARDS phenotypes/endotypes combining clinical and pathophysiologic parameters from a Canadian ARDS cohort.

Methods
A cohort of adult ARDS patients from multiple sites in Calgary, Canada, had plasma cytokine levels and clinical parameters measured in the first 24 h of ICU admission. We used a latent class model (LCM) to group the patients into several ARDS subgroups and identified the features differentiating those subgroups. We then discuss the subgroup effect on 30 day mortality.

Results
The LCM suggested three subgroups (n1 = 64, n2 = 86, and n3 = 30), and 23 out of 69 features made these subgroups distinct. The top five discriminating features were IL-8, IL-6, IL-10, TNF-a, and serum lactate. Mortality distinctively varied between subgroups. Individual clinical characteristics within the subgroup associated with mortality included mean PaO2/FiO2 ratio, pneumonia, platelet count, and bicarbonate negatively associated with mortality, while lactate, creatinine, shock, chronic kidney disease, vasopressor/ionotropic use, low GCS at admission, and sepsis were positively associated. IL-8 and Apache II were individual markers strongly associated with mortality (Area Under the Curve = 0.84).

Perspective
ARDS subgrouping using biomarkers and clinical characteristics is useful for categorizing a heterogeneous condition into several homogenous patient groups. This study found three ARDS subgroups using LCM; each subgroup has a different level of mortality. This model may also apply to developing further trial design, prognostication, and treatment selection.
CAR T cells outperform CAR NK cells in CAR-mediated effector functions in head-to-head comparison
Authors: Egli Lukas , Kaulfuss Meike , Mietz Juliane , Picozzi Arianna , Verhoeyen Els , Münz Christian , Chijioke Obinna 
Published: May 2024

Abstract
Background
CAR NK cells as vehicles for engineered “off-the-shelf” cellular cancer immunotherapy have attracted significant interest. Nonetheless, a comprehensive comparative assessment of the anticancer activity of CAR T cells and CAR NK cells carrying approved benchmark anti-CD19 CAR constructs is missing. Here, we report a direct head-to-head comparison of CD19-directed human T and NK cells.

Methods
We generated CAR T and CAR NK cells derived from healthy donor PBMC by retroviral transduction with the same benchmark second-generation anti-CD19 CAR construct, FMC63.28z. We investigated IFN-γ secretion and direct cytotoxicity in vitro against various CD19+ cancer cell lines as well as in autologous versus allogeneic settings. Furthermore, we have assessed anticancer activity of CAR T and CAR NK cells in vivo using a xenograft lymphoma model in an autologous versus allogeneic setting and a leukemia model.

Results
Our main findings are a drastically reduced capacity for CAR-mediated IFN-γ production and lower CAR-mediated cytotoxicity of CAR NK cells relative to CAR T cells in vitro. Consistent with these in vitro findings, we report superior anticancer activity of autologous CAR T cells compared with allogeneic CAR NK cells in vivo.

Conclusions
CAR T cells had significantly higher CAR-mediated effector functions than CAR NK cells in vitro against several cancer cell lines and autologous CAR T cells outperformed allogeneic CAR NK cells both in vitro and in vivo. CAR NK cells will likely benefit from further engineering to enhance anticancer activity to ultimately fulfill the promise of an effective off-the-shelf product.
Dietary fibre supplementation enhances radiotherapy tumour control and alleviates intestinal radiation toxicity
Authors: Then Chee Kin , Paillas Salome , Moomin Aliu , Misheva Mariya D. , Moir Rachel A. , Hay Susan M. , Bremner David , Roberts Kristine S. , Smith Ellen E. , Heidari Zeynab , Sescu Daniel , Wang Xuedan , Suárez-Bonnet Alejandro , Hay Nadine , Murdoch Sarah L. , Saito Ryoichi , Collie-Duguid Elaina S. R. , Richardson Shirley , Priestnall Simon L. , Wilson Joan M. , Gurumurthy Mahalakshmi , Royle Justine S. , Samuel Leslie M. , Ramsay George , Vallis Katherine A. , Foster Kevin R. , McCullagh James S. O. , Kiltie Anne E. 
Published: May 2024

Abstract
Background
Non-toxic approaches to enhance radiotherapy outcomes are beneficial, particularly in ageing populations. Based on preclinical findings showing that high-fibre diets sensitised bladder tumours to irradiation by modifying the gut microbiota, along with clinical evidence of prebiotics enhancing anti-cancer immunity, we hypothesised that dietary fibre and its gut microbiota modification can radiosensitise tumours via secretion of metabolites and/or immunomodulation. We investigated the efficacy of high-fibre diets combined with irradiation in immunoproficient C57BL/6 mice bearing bladder cancer flank allografts.

Result
Psyllium plus inulin significantly decreased tumour size and delayed tumour growth following irradiation compared to 0.2% cellulose and raised intratumoural CD8+ cells. Post-irradiation, tumour control positively correlated with Lachnospiraceae family abundance. Psyllium plus resistant starch radiosensitised the tumours, positively correlating with Bacteroides genus abundance and increased caecal isoferulic acid levels, associated with a favourable response in terms of tumour control. Psyllium plus inulin mitigated the acute radiation injury caused by 14 Gy. Psyllium plus inulin increased caecal acetate, butyrate and propionate levels, and psyllium alone and psyllium plus resistant starch increased acetate levels. Human gut microbiota profiles at the phylum level were generally more like mouse 0.2% cellulose profiles than high fibre profiles.

Conclusion
These supplements may be useful in combination with radiotherapy in patients with pelvic malignancy.
Pulling the lever in a hurry: the influence of impulsivity and sensitivity to reward on moral decision-making under time pressure
Authors: Del Popolo Cristaldi Fiorella , Palmiotti Grazia Pia , Cellini Nicola , Sarlo Michela 
Published: May 2024

Abstract
Background
Making timely moral decisions can save a life. However, literature on how moral decisions are made under time pressure reports conflicting results. Moreover, it is unclear whether and how moral choices under time pressure may be influenced by personality traits like impulsivity and sensitivity to reward and punishment.

Methods
To address these gaps, in this study we employed a moral dilemma task, manipulating decision time between participants: one group (N = 25) was subjected to time pressure (TP), with 8 s maximum time for response (including the reading time), the other (N = 28) was left free to take all the time to respond (noTP). We measured type of choice (utilitarian vs. non-utilitarian), decision times, self-reported unpleasantness and arousal during decision-making, and participants’ impulsivity and BIS-BAS sensitivity.

Results
We found no group effect on the type of choice, suggesting that time pressure per se did not influence moral decisions. However, impulsivity affected the impact of time pressure, in that individuals with higher cognitive instability showed slower response times under no time constraint. In addition, higher sensitivity to reward predicted a higher proportion of utilitarian choices regardless of the time available for decision.

Conclusions
Results are discussed within the dual-process theory of moral judgement, revealing that the impact of time pressure on moral decision-making might be more complex and multifaceted than expected, potentially interacting with a specific facet of attentional impulsivity.
Blood smears examination and prevalence of malaria in Addis Zemen Town, Northwest Ethiopia (2013–2021): a retrospective study
Authors: Adugna Tilahun , Zelalem Lamesgin , Alelign Gedafaw 
Published: May 2024

Abstract
Introduction
In Ethiopia, malaria is one of the major public health and socioeconomic problems, though tremendous efforts have been made. Currently, the country has a plan to eliminate malaria by 2030. To achieve this plan, epidemiological studies associated with malaria prevalence with gender, age groups, species types, and seasons are essential. Therefore, the aim of this study was to assess the prevalence of malaria from 2013 to 2021 in Addis Zemen town, Northwest Ethiopia.

Methods
A retrospective study was conducted at assess the trend of malaria prevalence over the last nine years using recorded blood smear reports in the laboratory logbook from governmental health institutions. Trends in malaria cases and the proportion of genders, age groups, species, and seasons over time were compared. The data were analyzed using the SPSS-23 software package.

Results
The overall malaria prevalence between 2013 and 2021 was 10.4%. From all confirmed cases, the minimum and maximum prevalence of malaria cases were recorded in 2018 (2%) and 2016 (33.2%) years, respectively. The infectious rate of males (59.3%) was significantly higher than that of females (40.7%) (p < 0.0001). In all survey periods, all age groups were infected by malaria parasites; the majority of the cases were between 15 and 45 years (57%) older than others. Statistically, a greater proportion of P. falciparum (80.1%) was recorded than P. vivax (18.5%) (p < 0.0001). Malaria cases were occurring throughout each month. The relative highest peaks of total malaria cases were observed during the months of September, October, and November. Seasonally, the highest infection rate was observed during spring (40.20%) compared to other seasons.

Conclusions
In conclusion, the study revealed that malaria transmission remained high, which affected males more than females and potentially reproductive ages. Two of the most important Plasmodium species were identified and found during all reviewed months and years, though P. falciparum was the most prevalent. Hence, the problem can be alleviated by using season-based long-lasting insecticide treated nets, regularly overseeing ongoing irrigation activity, overseeing the reduction of the water level of the Sheni River, health education, and providing immediate patient treatment.
Unveiling the retinal secrets of neuromyelitis optica spectrum disorder
Authors: Ashour Amal S. , El Serafy Omar , El Fayoumy Nervana Mohamed , Hassan Amr , El Gendy Nehal Samy , Heikal Eman Salah , Ahmed Hadeel , Al-Azayem Salsabil Abo 
Published: May 2024

Abstract
Background
Vascular alterations are now recognized as important contributors to the pathophysiology of neuromyelitis optica spectrum disorder (NMOSD). This study aimed to use optical coherence tomography (OCT) and OCT-angiography (OCTA) to assess alterations in the retinal structure and microvasculature in patients with NMOSD, so we can understand pathophysiology of NMOSD, implicating this on disease activity, visual outcome and management on the future.

Methods
A case–control study was conducted on 40 NMOSD patients with (NMOSD + ON) and without (NMOSD – ON) history of optic neuritis and 36 healthy subjects. The following data were assessed in NMOSD patients: clinical history, EDSS, and visual function testing. Both groups underwent spectral domain (SD)-OCT and OCTA.

Results
In this study, NMOSD + ON patients had a statistically significant reduction in all SD-OCT parameters compared to healthy control. Regarding OCTA, there was a significant reduction in radial peripapillary capillary density (RPCD) in NMOSD + ON (P-value < 0.001) and some sectors of NMOSD–ON compared to healthy control. NMOSD + ON patients had significant differences in RPCD compared to those without (P-value < 0.001).

Conclusions
Here we show that the advance of this study is that retinal microvascular alterations have been noticed in NMOSD–ON eyes, indicating that subclinical primary retinal vasculopathy and disease activity may occur in NMOSD before onset of ON and retinal atrophy. This may have implications on early detection of disease activity, early interference in management and prognostic tool to visual outcome in following the patients.
An Overview of Modern Strategies for Treating Obesity
Authors: Jędrasek Aleksandra , Barg Marta , Biały-Karbowniczek Julia , Bartela Agata , Wojtyła Klaudia 
Published: May 2024

Introduction: In the last few years, obesity has become a central issue with more than 2.6 billion people worldwide being overweight or obese. While the risks associated with this condition and its rising significance are widely known, the effect of this attention on screening and treatment remains unsatisfying. This paper explores multiple treatment strategies and evaluates their effectiveness in preventing obesity-related complications.
Review methods: We conducted our study as a literature review, with data being gathered via PubMed and Embase.
The state of knowledge: Physical activity, behavioral therapy, and proper nutrition remain the foundation for obesity therapy. However, in many cases these approaches are insufficient. Recently, there has been a dynamic development of bariatric surgery and new drugs, which in comparison to lifestyle modification, result in better long-term results and improved quality of life. New surgery procedures, such as sleeve gastrectomy and adjustable gastric banding, have shown to be one of the most effective but still carry a risk of complications. As an alternative pharmacotherapy could be considered with currently used medications including liraglutide, semaglutide, tirzepatide, phentermine-topiramate, orlistat, and bupropion-naltrexone.
Conclusions: Growing treatment options allow physicians to choose more targeted approaches, based on the patient’s risk factors, overall health status, and compliance.