bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prognostic performance of Krebs von den Lungen-6, surfactant protein A, surfactant protein D levels in the serum and bronchoalveolar lavage fluid in chronic fibrosing interstitial pneumonia: A retrospective study
Authors: Wakamatsu Kentaro , Nagata Nobuhiko , Kumazoe Hiroyuki , Hara Makiko , Asai Satomi , Noda Naotaka , Kiyotani Ruriko , Fukui Izumi , Tatsuta Miyoko , Katahira Katsuyuki , Akasaki Takashi , Maki Sanae , Miyamoto Kouta , Otsuka Junji , Izumi Miiru , Kawasaki Masayuki , Yamada Hozumi 
Published: May 2024

Abstract

Background: The serum markers Krebs von den Lungen-6 (KL-6), surfactant protein A (SP-A), and surfactant protein D (SP-D) have been used for the diagnosis, differential diagnosis, and prognosis prediction of interstitial pneumonia. However, the significance of measuring the serum and bronchoalveolar lavage fluid (BALF) KL-6, SP-D, and SP-A levels in predicting the prognosis of chronic fibrosing interstitial pneumonia (CFIP), idiopathic pulmonary fibrosis, and idiopathic nonspecific interstitial pneumonia remains unclear. We aimed to clarify the significance of measuring the serum and BALF KL-6, SP-A, and SP-D levels in predicting the prognosis of patients with CFIP.
Methods: Among 173 patients who were diagnosed with CFIP between September 2008 and February 2021, 39 who underwent bronchoalveolar lavage were included in this study. Among these, patients experiencing an annual decrease in forced vital capacity (FVC) of ≥10% or those facing challenges in undergoing follow-up pulmonary function tests owing to significant deterioration in pulmonary function were categorized as the poor prognosis group. Conversely, individuals with an annual decrease in the FVC of <10% were classified into the good prognosis group. The serum and BALF KL-6, SP-D, and SP-A levels, as well as BALF/serum SP-D and SP-A ratios were compared between the two groups.
Results: Among the patients with CFIP, the BALF SP-D level (p=0.0111), BALF SP-A level (p<0.0010), BALF/serum SP-D ratio (p=0.0051), and BALF/serum SP-A ratio (p<0.0010) were significantly lower in the poor than in the good prognosis group (p<0.0010). The receiver operating characteristics analysis results demonstrated excellent performance for diagnosing patients with CFIP, with the BALF SP-D level (area under the curve [AUC], 0.7424), BALF SP-A level (AUC, 0.8842), BALF/serum SP-D ratio (AUC, 0.7673), and BALF/serum SP-A ratio (AUC, 0.8556). Moreover, the BALF SP-A level showed a notably superior CFIP diagnostic capability. Survival analysis using the Kaplan–Meier method revealed that patients with a BALF SP-A level of <1500 ng/mL and BALF/serum SP-A ratio of <15.0 had poor prognoses.
Conclusions: Our results suggest that BALF SP-A measurement may be useful for predicting the prognosis in patients with CFIP.
Optimal Extraction of Xuetongsu and its Mechanisms in Inhibiting RA Synovial Hyperplasia: Intervention in Migration and Apoptosis of Synovial Cells
Authors: Deng Yasi , Zheng Hao , Liu Shiqi , Deng Ying , Chen Yuxin , Liang Ling , Wang Mengyun , Xie Qingling , Yang Yupei , Li Bin , Huang Juan , Yuan Hanwen , Wang Wei , Yu Huanghe 
Published: May 2024

Abstract

Kadsura heteroclita (Roxb) Craib also named Xuetong in Tujia ethnomedicine in China, has been traditionally employed in rheumatoid arthritis (RA) treatment. Our preceding investigations have elucidated that Xuetongsu (XTS), a triterpenoid compound predominant in Xuetong, showed excellent anti-RA-fibroblast-like synoviocytes (RAFLS) proliferation effect. However, XTS belongs to the trace components of the Xuetong plant, this poses certain limitations to the research. In this study, we designed a method that enhanced the extraction yield of XTS and explored the mechanism of its treatment of RA in inhibiting RAFLS cell proliferation and migration. The results displayed that XTS reduced RAFLS cell proliferation, with an IC50 value of 4.68±0.65 μM. A series of experimental techniques were utilized to show that XTS induce apoptosis in RAFLS cells at concentrations ranging from 4.5 to 18 μM, including wound healing assays, flow cytometry, and Western blot analysis. Moreover, XTS at dosages of 0.42-0.84 mg/kg markedly attenuated paw swelling and synovial hyperplasia in arthritic rats, primarily through the inhibition of RAFLS migration and promotion of RAFLS apoptosis via High mobility group box 1 (HMGB-1)/Matrix metalloproteinase-9 (MMP-9) signaling pathway and Bcl-2/Bax/Caspase-3 signaling pathway, respectively.
Two Decades of Change in Living arrangements and Oldest Old Health in China, 1998-2018
Authors: Zhang Li 
Published: May 2024

Abstract

Living arrangement has been documented to be influential on older adults’ health. However, there is hardly comprehensive temporal model for understanding the effects of time and cohort on oldest old’s health in various household contexts. This study intended to fill the voids of prior literature by studying Chinese oldest old through analyzing data from eight (1998, 2000, 2002, 2005, 2008, 2011-12, 2014 and 2018) waves of the Chinese Longitudinal Healthy Longevity Survey (CLHLS). The results showed changing patterns of Chinese oldest old’s living arrangements by time period and across birth cohorts. Chinese oldest old were more inclined to live with a spouse or live alone. Living in nursing homes was also chosen by more oldest old in recent years. Younger cohorts were more inclined to live with a spouse, live both with a spouse and adult children/grandchildren or live alone than older birth cohorts. Oldest old who lived with a spouse only, and those living in multigenerational families tended to have better physical and mental health. Respondents who lived in nursing homes and stayed with others showed the worst physical and mental health. Oldest old who lived alone had better physical health but suffered from loneliness and reported the worst subjective wellbeing. Significant period and cohort variations were also found when linking living arrangements to oldest old health. Cohort variations mainly occurred among subgroups living alone, staying in nursing homes and living with others. Period effects were more prominent than cohort effects, especially in times of economic recessions and natural disasters that had massive social impacts. The study emphasized strong period effects and highlighted that special attention should be given to more vulnerable groups to promote their health, including those living alone, living in nursing homes and living with others.
Association between Weight-Adjusted Waist Index and Depression in NAFLD: The Modulating Roles of Sex and BMI
Authors: Zhang Jingwen , Wang Yan , Xie Tianyu , Liu Lijun , Fu Xiaoyu , Wang Chenhao , Ke Sunkui , Huang Xiao 
Published: May 2024

Abstract

Background
The Weight-Adjusted Waist Index (WWI) is a novel indicator of obesity that accurately reflects body composition. However, the association between WWI and depression in patients with non-alcoholic fatty liver disease (NAFLD) remains unclear. This study aims to explore this relationship through a nationally representative cross-sectional analysis.
Methods
This study included adult participants diagnosed with NAFLD from NHANES 2017–2020. WWI was calculated as the waist circumference (cm) divided by the square root of body weight (kg). NAFLD diagnosis relied on vibration-controlled transient elastography (VCTE) with a controlled attenuation parameter (CAP) exceeding 248 dB/m to indicate hepatic steatosis. Depression was assessed using the Patient Health Questionnaire-9 (PHQ-9), with scores ≥ 10 indicating the presence of major depression.
Results
After adjusting for all covariates, a significant positive association was found between WWI and depression in NAFLD (OR = 1.725, 95% CI: 1.442–2.063, p < 0.00001), with a dose-response relationship indicated by restricted cubic spline analysis. The association was stronger in men and lean NAFLD patients. Adjusting further for BMI did not alter these findings (OR = 1.643, 95% CI: 1.357–1.989, p < 0.00001). BMI's association with depression was negated after adjusting for WWI.
Conclusions
WWI had a positive association with depression in NAFLD, independent of BMI. This association was more pronounced in men and lean NAFLD. These findings suggest that WWI may be a novel predictor of depression in NAFLD and potentially valuable in depression prevention.
Study on Overlap of Carburizing 18CrNiMo7-6 Alloy Steel Strengthened via Abrasive Water Jet
Authors: Liu Lanrong , Sun Baocheng , Xu GuangTao , Ma YongTao , Zhao Minghao , Zhao Zhenye 
Published: May 2024

Abstract

Abrasive water jet technology has been applied to strengthen the surfaces of complex shapes and high-strength components to improve their fatigue life. In this regard, the energy distribution affects the strengthening; hence, its uniformity must be comprehensively investigated. The main parameters affecting the energy-distribution uniformity are the particle performance parameters, particle velocity distribution, particle spatial distribution, and overlap. In this study, theoretical models of single-pass energy distribution and multipass lap energy distribution are established by considering the spatial and velocity distributions of particles. Additionally, the ratio of the energy difference to the maximum energy in the lap range is determined as the index of energy-distribution uniformity. Based on the relationship between deformation and energy, the theoretical model is verified using 18CrNiMo7-6 alloy steel. Results show that the maximum theoretical deformation in a single pass is consistent with the experimental results, with an error of less than 6%; additionally, the theoretical and experimental peak and trough differences after a multipass lap show good agreement. Using the proposed model, the lap distance can be obtained to guide practical engineering applications.
Principled Personalised Operative Strategy using 3D Virtual Modelling Ahead of Complete Mesocolic Excision with Central Vascular Ligation for Proximal Colon Cancer.
Authors: Kearns Emma Claire , Moynihan Alice , Khan Mohammad Faraz , Lawler Leo , Cahill Ronan A 
Published: May 2024

Abstract

Purpose
Here we report the usefulness of 3D virtual modelling (3DVM) for surgical planning before complete mesocolic excision (CME) and central vascular ligation (CVL) for proximal colon cancer including direct comparison to operative course and intraoperative perfusion assessment by near infrared fluorescence angiography (NIFA).
Methods
26 patients underwent CT mesenteric angiogram with subsequent 3DVM (VisiblePatient©) in advance of undergoing laparoscopic right or extended-right hemicolectomy with CMECVL. 3DVM were studied by the surgical team in advance of each case and their planned operative strategy recorded. Operative notes and findings were reviewed to determine deviations from this strategy and physiological measures of perfusion at the prepared transection levels.
Results
Operative plans were made in every case based on tumour location (caecal versus non-caecal location) and patient 3DVM vascular anatomy and were followed without significant deviation in every case (NIFA supported the predicted transection level in all). 22 patients had complete operative notes available for comparative analysis. All patients had MA confluence with the inferior mesenteric artery territory on 3DVM and eight had independent RCAs. 12 patients had truncal MCA ligation with the left branch and indeed the entire MCA being preserved in 8 and 1 respectively (one patient with previous surgery had no MCA). Side to side ileocolic anastomosis was made with the distal transverse colon in 20 cases and with the descending colon in 2. There were no anastomotic complications postoperatively.
Conclusion
3DVM can efficiently enable accurate personalized planning ahead of CME-CVL including indicating anastomotic perfusion sufficiency by vascular anatomy.
A Novel Treatment Algorithem for Infected Diabetic Foot Ulcers- One Step Procedure
Authors: Genuth Gil , Ulrich Martin , Klammer George , Iselin Lukas 
Published: May 2024

Abstract

Background
Foot and ankle infections are the most common reason for hospital admissions and have the most devastating and costly complications in patients with diabetes mellitus worldwide.
Foot ulceration can lead to a limb or even life-threatening infection. It is estimated that 85% of all amputations in diabetic patients are related to an ulcer and 59% of amputation are performed due to infection. When treating diabetic foot ulcers, achieving eradication of the infection and saving the limb can be difficult. In order to avoid amputation, which often is associated with functional impairment, the goal of treatment should be to be as preserving as possible. We would like to present our new treatment algorithm for infected diabetic foot ulcers in the first ray. This new algorithm avoid amputation and preserve ambulation.
The new treatment algorithm includes: A thorough debridement of the ulcer, Primary stabilization by fusing the infected joint and closing the skin over the ulcer and the fused joint.
We would like to present our experience with this new treatment algorithm.
Methods
This is a retrospective Study. The study includes 34 patients(36 feet) with IPJ or 1st MTPJ septic arthritis or osteomyelitis due to diabetic ulcers between 2018-2021 treated in a tertiary referral hospital.
All patients had preoperative radiographs, 17 patients had a preoperative MRI scan and were evaluated pre or postoperatively by angiography. A thorough debridement was performed until macroscopically judged clear of infection. Histology and microbiology samples were collected during surgery. The fusion of the infected joint was made under fluoroscopy control. Wound closure was performed with minimal soft tissue tension. All the patients were followed up for an average period of 12 months after surgery.
Results
By one year after surgery healing of the ulcer was achieved in 86% (31/36) of the cases.
Overall average time to heal was 6.9 weeks (range 1-20 weeks). One year postoperatively radiological fusion was achieved in 26/36 (72%) cases. Clinically, by one year after surgery, 28 of 36 cases (77%) were stable on physical examination.
Conclusion
One Step Debridement and Arthrodesis of IPJ or 1st MTPJ in diabetic foot patients with an ulcer and infection proved to be a successful way of treatment. A thorough debridement of the infected tissue and stabilizing the joint in the same procedure dramatically reduce the number of 1st toe or 1st ray amputation, improve patient’s satisfaction and help maintain a good walking pattern and mobilization.
Level of Evidence: III
Enhanced the immunity activity of HPV16 DNA vaccine by the combination CpG oligonucleotides adjuvant cloned into plasmid backbone and IL-28B gene adjuvant
Authors: zhou yan , Zhang Ting , Wang Zhirong , Xu Xuemei 
Published: May 2024

Abstract

Therapeutic human papillomavirus (HPV) DNA vaccine is an attractive option to control existed HPV infection and related lesions. The two early viral oncoproteins, E6 and E7, are continuously expressed in most HPV-related pre- and cancerous cells, and are ideal targets for therapeutic vaccines. We have previously developed HPV 16 DNA vaccines encoding mE7/HSP70, which generated significant antitumor effects in mice. In this study, we utilized multiple strategies including the insertion of CpG oligonucleotides (ODNs) into the backbone of vaccine vector, selection of cytokine gene adjuvants, combination of mE6/HSP70 and mE7/HSP70, vaccination with electroporation, to further enhance the potency of HPV16 DNA vaccine, We found that combination of built-in CpG adjuvant and IL-28B gene adjuvant could induce higher CD8+T cell response in mice. Moreover the plasmids mE6/HSP70 combined with mE7/HSP70 could synergistically enhance the specific CD8+T cell response. Furthermore, vaccination with CpG-modified mE7/HSP70 and mE6/HSP70, plus IL-28B gene adjuvant, generated significantly preventive and therapeutic antitumor effect against HPV E6- and E7-expressing tumors in C57BL/6 mice. Our results suggested that it may be promising to effectively control HPV infection and associated diseases by combining these multiple strategies in HPV DNA vaccine.
Fenofibrate reduces pain hypersensitivity and associated depression-like behavior in mice with oxaliplatin- induced neuropathy
Authors: Yue Liang , Yuan Yimin , Li Dai , Sun Li , Shen Yijia , Ma Yu , Cao Li , Xiong Yuanchang 
Published: May 2024

Abstract

The population of patients with chemotherapy-induced neuropathy is increasing in parallel with the growing number of cancer survivors, creating an urgent need for effective treatments that address both the neuropathic symptoms and the accompanying depression. In this study, we established a mouse model of chronic oxaliplatin-induced neuropathy (OIPN) that closely mimics significant cold and mechanical allodynia, along with depression-like behaviors observed in patients, over a clinically relevant timeframe. We investigated the effects of fenofibrate on pain hypersensitivity and depression-like behaviors in the OIPN mouse model. Administration of fenofibrate significantly reduced mechanical allodynia in the Von Frey test and cold allodynia in the cold plate test among OIPN mice. Moreover, fenofibrate reduced depression-like behaviors in OIPN mice, as demonstrated by improved performance in the forced swimming test, sucrose preference test and tail suspension test. The analgesic and antidepressant-like effects observed with fenofibrate may be linked to its protective actions on oligodendrocyte progenitor cells (OPCs) in the medial prefrontal cortex (mPFC) of oxaliplatin-treated mice. These findings suggest that fenofibrate holds promise as a potential therapeutic agent for the prevention and treatment of OIPN, offering relief from both pain and comorbid depressive symptoms. Further clinical testing is warranted to confirm its efficacy and safety in this context.
OIDS-45: A large-scale benchmark insect dataset for orchard pest monitoring
Authors: Chen Hongkun , Chen Junyang , Xie Yingjie , He Hangfei , Zhang Boyi , Guo Jingjie , Wan Li , Chen Xiaoyan 
Published: May 2024

Abstract

Insects play a crucial role in agricultural production and should not be overlooked. However, there is currently no large-scale dataset available specifically for common insects in orchards. Additionally, datasets for computer vision target detection tasks are limited in the field of insects, which hinders the use of deep learning target detection techniques in orchard insect monitoring. This paper presents the OIDS-45 dataset, which is a large-scale dataset for orchard insect monitoring. The dataset contains 58,585 images of 45 categories of common insects found in orchards. The dataset exhibits a long-tailed distribution, and all images are labeled with borders, making them useful for target detection tasks. The dataset represents the category of orchard insects and has a larger sample size, more categories, and more features in the orchard scenario than previous datasets. We compared our dataset with existing typical insect datasets using advanced target detection algorithms to evaluate its features and quality. The experimental results indicate that current target detection algorithms are not yet capable of accurately identifying and detecting insects in orchards. This is due to the small size of individual insects, the morphological similarities between some species, and the existence of multiple growth stages in some insects. The production and release of this dataset aim to support research in the fields of orchard pest control and insect monitoring in orchards.
Comparison of Canadian online pharmacies with conventional pharmacies for erectile dysfunction drugs. The Cost of Convenience and discretion
Authors: Morra Michael , Morra Michael , Dhillon Harliv , Dhillon Harliv , Patel Premal , Patel Premal 
Published: May 2024

Abstract

Introduction
Erectile dysfunction (ED) is a common condition affecting about 50% of men over the age of 40. ED can be related to cardiovascular disease and diabetes requiring further evaluation and workup, unfortunately many men with ED commonly avoid seeking treatment for reasons such as embarrassment. In the past few years, multiple online pharmacies offering easy access to ED medications have emerged, advertising easy online forms, no conventional doctors visit and discreet delivery to their home. We sought to compare the prices of five popular online ED pharmacies with conventional pharmacies, hypothesizing that online pharmacies would come at increased cost to patients.
Methods
The five online pharmacies were found on the first result page of a google search for “ED drugs online Canada”. Consumer prices for Tadalafil and Sildenafil were acquired through available website information or by contacting customer service. The prices were expressed as price per pill and compared with four conventional pharmacies in Winnipeg, Manitoba. Pricing differences were expressed as a percentage.
Results
When comparing the price per pill of the smallest order of tabs that can be purchased, the price of ED medications from online pharmacies was on average 15% higher without including the dispensing fee of the conventional pharmacy comparators. Once taking dispensing fees into account, the cost ED medications from conventional pharmacies was about 3-4% higher compared to online conventional pharmacies. Dispensing fees ranged from $12.99 to $16.00 per order. Savings could be seen with conventional pharmacies when order quantities increased as the dispensing fee is fixed per order.
Conclusions
Online pharmacies in Canada that boast convenience and discretion to customers offer similar pricing to conventional pharmacies. Despite their competitive pricing, their focus on discretion further perpetuates common stereotypes of ED that may prevent men from seeking help from their care providers.