bluuebunny/crossref_metadata_2025_split huggingface dataset:
Anthropometric assessment of classroom furniture for Ghanain school children from two socio economic areas.
Authors: Mensah Claudia A. , Agyemang-Beniako Afia , Newton Sam , Sulemana Alhassan , Djimatey Moses , Hogarh Jonathan N. , Kwesi Sabastian Samuel 
Published: June 2024

Abstract

Children spend over 80% of their school time in a seated position yet, ergonomic principles are conservatively applied on adult work places without consideration to the school environment. This study assessed the compatibility of the school furniture of kindergarten and class one pupils in the Asokore Mampong and Oforikrom Municipalities, Ghana.
A cross-sectional analytic study was used. The research covered four selected basic schools from two socioeconomic suburbs (relatively high and relatively low socioeconomic areas).
The participants were chosen using stratified sampling. Anthropometric data were collected from 395 healthypupils during regular class lessons. The student furniture dimensions were taken and compared with their anthropometry to identify potential match or mismatch. For all sitting anthropometric parameters, students were seated in an upright position with 90º knees and elbow flexion.
The findings revealed a considerable level of discordancy between the measured furniture and the anthropometrics of the learners due to the negligence of user anthropometry during the construction of educational furniture. The seat depth was too deep for 80.51% of participants, only 15.19% had appropriate seat depth. The seat to desk height had 25.06% match, 69.11% low mismatch and 5.82% high mismatch. The match percentages of seat desk clearance, seat width and desk depth were 72.91%, 66.08% and 36.46% respectively. The match percentages of seat height were 24.61% for low socio-economic area schools and 12.25% for high socio-economic area schools. The seat height was too low for 45.55% of pupils from low socio-economic area schools and 62.25% of those from high socio-economic area schools. The seat depth was too deep for 91.62% of pupils from low socio-economic area schools and 70.10% pupils from high socio-economic area schools.
The study revealed considerable incompatibility between the classroom furniture and the body dimensions of the pupils. Thus, the classroom furniture require ergonomic improvements.
Colorimetric Identification of Colorless Acid Vapors using a Metal-Organic Framework-Based Sensor
Authors: Kim Jin Yeong , Jang Wonhyeong , Yoo Hyejin , Shin Dongjun , Noh Seokjin 
Published: June 2024

Abstract

In terms of safety and emergency response, identifying hazardous gaseous acid chemicals is crucial for ensuring effective evacuation and administering proper first aid. However, current studies struggle to distinguish between different acid vapors and remain in the early stages of development. In this study, we propose a novel on-site monitorable acid vapor decoder, MOF-808-EDTA-Cu, integrating the robust MOF-808 with Cu-EDTA, functioning as a proton-triggered colorimetric decoder that translates the anionic components of corrosive acids into visible colors. The sensor exhibits a remarkable cyan-to-yellow shift when exposed to HCl vapor and can visually differentiate various acidic vapors (HF, HBr, and HI) through unique color changes. Furthermore, the compatibility of the MOF-based sensor with multiple metal ions having atomic-level dispersion broadens its discrimination range, enabling the identification of six different colorless acid vapors within a single sensor domain. Additionally, by incorporating a flexible polymer, the MOF-808-EDTA-Cu has been successfully processed into a portable miniaturized acid sensor, exhibiting distinct color changes that can be easily monitored by the naked eye and camera sensors. This provides experimental validation as a practical sensor capable of on-site 24-hour monitoring in the real world.
Fatigue syndrome after COVID-19 infection: results of personal observations
Authors: Kolesnikov P. E. , Vizel A. A. , Abashev A. R. , Davydova L. V. 
Published: June 2024

Introduction. The novel coronavirus disease (COVID-19) pandemic has presented challenges for health systems globally. However, as the number of COVID-19 survivors continue to increase, we get more and more evidence on the long-lasting symptoms after an acute infection. According to some studies, the total number of symptoms described can reach 200, but fatigue is considered the key presentation in such patients. The subjectivity of fatigue concept continues to be a significant obstacle to its study: the absence of validated assessment methods does not allow to adequately assess the prevalence and significance of fatigue in patients with lung injury induced by COVID-19.Aim. To assess the prevalence of fatigue syndrome in patients with lung injury induced by COVID-19 using a validated tool, the Fatigue Assessment Scale, and risk factors for the development of this condition.Materials and methods. Medical records of patients hospitalised for PCR-confirmed new coronavirus infection COVID-19 with lung lesions (n = 100), evaluated using the FAS scale, were retrospectively analysed. Statistical processing of the data was performed.Results. Objectively assessed fatigue was detected in 66% of patients. Statistically significant association between fatigue syndrome and obesity, severity of acute phase of infection, presence of comorbidities, Charlson comorbidity index was revealed.Conclusions. The use of objectification methods makes it possible to assess the prevalence and significance of fatigue syndrome in patients with COVID-19-induced lung lesions, to perform statistical analysis of possible risk factors for the development of this condition.
Clinical and allergological characteristics of patients with severe bronchial asthma in the regional registry and phenotyping principles for the targeted therapy choice
Authors: Naumova V. V. , Beltyukov E. K. , Kovtun O. P. , Smolenskaya O. G. , Bykova G. A. , Klyachina E. S. 
Published: June 2024

Introduction. Severe asthma targeted therapy effectiveness depends on precise targeting of the selected drug to the key link in pathogenesis. Therefore, severe asthma phenotyping in real clinical practice is relevant.Aim. To determine main clinical and allergological characteristics of patients with severe asthma and to establish important phenotyping signs determined choice of a targeted drug for severe asthma treatment.Materials and methods. The prospective and retrospective study involved patients (n = 198) of the Sverdlovsk region registry receiving targeted therapy of severe asthma. Considering clinical and allergological picture, allergic, non-allergic eosinophilic and mixed severe asthma phenotypes were identified. Clinical and laboratory characteristics of phenotypes were described. A phenotyping algorithm was developed.Results. In the register of patients (n = 198) with severe asthma, non-allergic eosinophilic asthma was 46.5%, allergic – 34.8%, mixed – 18.7%. Significant signs for phenotyping were identified: age of asthma onset, proven allergy, Phadiatop ImmunoCAP level and blood eosinophils on baseline, concomitant allergic rhinitis, chronic rhinosinusitis with nasal polyps and hyper-sensitivity to NSAIDs. The main signs of allergic severe asthma determined: early onset, proven allergy and a positive result of Phadiatop ImmunoCAP (the probability of allergic phenotype increases with Phadiatop ≥ 1.53 PAU/l). Signs of non-allergic eosinophilic asthma were eosinophilia ≥ 150 cells/µl, absence of allergy, concomitant chronic rhinosinusitis with nasal polyps and hypersensitivity to NSAIDs, late onset (after 30 years). Signs were identified for mixed asthma: presence of proven allergy or latent sensitization in combination with high level of Phadiatop ImmunoCAP, late onset, eosinophilia ≥ 300 cells/µl, chronic rhinosinusitis with nasal polyps, hypersensitivity NSAIDs.Conclusions. The algorithm for severe asthma phenotyping based on the isolation of eosinophilia of allergic and non-allergic origin is proposed. Severe asthma phenotyping, which can be carried out in real clinical practice, should facilitate the selection of an initial targeted drug.
Clinical experience of using Polysorb in complex pathogenetic therapy of chronic hepatitis C with severe liver fibrosis
Authors: Konstantinov D. Yu. , Popova L. L. , Vasilev S. Yu. , Popilov M. A. 
Published: June 2024

Introduction. Violation of metabolic processes in the gastrointestinal tract in patients with chronic hepatitis C (HCV) leads to the accumulation of toxic metabolic products in the intestine, negatively affecting both the balance of the microbiota and the functional state of hepatocytes. The sorption of toxins released by opportunistic anaerobic bacteria contributes to the restoration of the population of bifidobacteria and lactobacilli, which has a beneficial effect on the functional state of the liver.Aim. To evaluate the clinical and laboratory efficacy and safety of Polysorb as part of complex pathogenetic therapy in patients with HCV with severe liver fibrosis.Materials and methods. The study included 62 patients with HCV in the stage of severe liver fibrosis (F3 according to METAVIR) of both sexes aged 18 to 65 years who were not receiving antiviral therapy. In the study group, pathogenetic therapy was supplemented with Polysorb. Clinical and laboratory parameters were evaluated before and after the course of treatment. The study of the intestinal microbiota was carried out by determining the concentration of volatile fatty acids (VFA) in the intestinal contents: acetic, propionic, butyric, the total content of isoC4 + isoC5 + isoC6 and the value of the anaerobic index by gas-liquid chromatography (chromatograph “Tsvet 100”, Russia).Results and discussion. Complex pathogenetic therapy of patients with HCV (F3), including the enterosorbent Polysorb, increases the effectiveness of treatment for clinical syndromes: right hypochondrium by 35.8%, asthenovegetative – by 13.6%, dyspeptic – from 8 to 22.5% (according to individual symptoms), cholestatic – by 8%, and also improves the biochemical parameters of liver function: p = 0.060; GGTP, p = 0.014 and it helps to stabilize the composition of the microbiota, increasing the total level of LVH (p < 0.05), mainly due to normalization of acetic acid values, improvement of the anaerobic index: before treatment -0.858 ± 0.152, after -0.601 ± 0.163 (p < 0.05).Conclusion. The inclusion of Polysorb in the pathogenetic therapy of patients with HCV (F3) helps to stabilize the composition of the microbiota, while no side effects or adverse events have been recorded.
Direct comparative study of anti-IgE and anti-IL4Rα therapy effectiveness in patients with severe allergic and mixed bronchial asthma
Authors: Naumova V. V. , Beltyukov E. К. , Kovtun О. P. , Bykova G. A. , Troshina V. I. , Mineeva A. N. 
Published: June 2024

Introduction. There is insufficiency of direct comparative studies of genetically engineered biological drugs (GEBD) for severe bronchial asthma (SA) treatment in scientific databases.Aim. To compare omalizumab and dupilumab effectiveness in patients with allergic and mixed SA in real clinical practice.Materials and methods. The direct comparative study included SA patients with an allergic component from regional registry of Sverdlovsk region. The data of patients with allergic (n = 68) and mixed (n = 27) SA treated with omalizumab (n = 62) and dupilumab (n = 33) were analyzed. Therapy effectiveness was determined for 12 months in general group No. 1, allergic asthma group No. 2 and mixed asthma group No. 3 according to the following indicators: asthma control level (ACT), proportion of patients with uncontrolled asthma, need for systemic glucocorticosteroids (SGCS) and short‐acting beta agonists (SABA), basic therapy volume, asthma exacerbations number, emergency calls and hospitalizations, forced expiratory volume in the first second (FEV ), assessment of life quality (AQLQ and SNOT-22). Control evaluation visits were conducted before therapy start, after 4 and 12 months of biologics taking.Results. In general, during the 12 months of targeted therapy in patients receiving omalizumab statistically significant positive dynamics was observed in 12 of the 13 evaluated indicators; in patients receiving dupilumab – in 9 indicators. When analyzing such indicators as, ACT, taking SGCS, exacerbations of SA, FEV , statistically significant positive dynamics was revealed for all 4 indicators in patients receiving omalizumab in group No. 2 and in patients receiving dupilumab in group No. 3.Conclusions. Patients with allergic component of SA respond equally well to therapy with omalizumab and dupilumab. At the same time, a tendency towards the advantage of omalizumab in patients with allergic asthma, and dupilumab in patients with a mixed phenotype of the disease was revealed.
Epithelial cell proliferation index in patients with atrophic gastritis depending on the presence of complete or incomplete intestinal metaplasia in the gastric antrum
Authors: Ryabokon R. V. , Tsukanov V. V. , Khorzhevskii V. A. , Vasyutin A. V. , Tonkikh J. L. 
Published: June 2024

Introduction. There is a debate about the significance of intestinal metaplasia (IM) subtypes for the development of gastric cancer. Therefore, determining the indicators of cellular renewal in individuals with complete and incomplete IM is certainly a topical issue.Aim. To study the proliferative activity of epithelial cells of the gastric antrum in patients with Helicobacter pylori-positive antral atrophic gastritis depending on the subtype of IM.Materials and methods. The study included 20 people with chronic antral non-atrophic gastritis (CNG; group A), 20 patients with chronic antral atrophic gastritis (CAG) without IM (group B), 20 patients with CAG with complete IM (group C) and 20 people with CAG with incomplete IM (group D). The stage of chronic gastritis was assessed by the morphological method in accordance with the modified Sydney classification. Typing of IM foci in the gastric mucosa was performed using the PAS reaction. Proliferation activity was studied by the expression of nuclear protein Ki67 using immunohistochemistry.Results. The proliferation index in the foci of complete BM in group C was 5%, and in group D in the foci of incomplete BM the Ki67 expression index was significantly higher and was 39% (p < 0.001). Outside the foci of metaplasia, the proliferation index was 23.5% in group C and 19% in group D (p = 0.06).Conclusion. We have registered significantly higher proliferation indicators of gastric epithelial cells in foci with incomplete IM compared to foci with complete IM. Determination of proliferation indicators in foci of incomplete intestinal metaplasia may be a marker of an increased risk of developing gastric cancer.
6-minute walk test in patients hospitalized with COVID-19
Authors: Kanaeva T. V. , Karoli N. A. 
Published: June 2024

Introduction. The 6 Minute Walk Test (6MWT) plays a key role in assessing functional exercise tolerance and prognosis for a wide range of chronic respiratory and cardiovascular diseases. In acute bronchopulmonary diseases, in particular COVID-19, there is practically no data on the possibilities of using 6MWT.Aim. To compare the results of a 6-minute walk test with clinical and laboratory parameters of patients hospitalized with new coronovirus infection.Materials and methods. The prospective, non-randomized comparative study sequentially enrolled 117 patients hospitalized with a confirmed diagnosis of COVID-19. Upon admission to the hospital, all patients performed 6MWT in accordance with international recommendations.Results. During the 6-minute trial, patients walked an average of 390 m (340.0; 420.0). In 96.6% of patients, there was a marked limitation of physical activity. Desaturation during the 6-minute test was registered in 25 (21.4%) patients. When conducting a correlation analysis, it was found that the result of the test with physical activity (the number of meters traveled) is associated with both initial and final SpO2, the presence of desaturation and the severity of dyspnea according to Borg, with the age of patients, the severity of the course of new coronovirus infection, laboratory signs of the activity of the inflammatory process upon admission. Relationships between the results of 6MWT (the number of meters covered and the % decrease in SpO2) and the duration of hospitalization, the maximum volume of lung damage according to CT data, the maximum severity of laboratory signs of inflammation (CRP, ferritin) during hospitalization, the need for oxygen therapy, the volume of anti-inflammatory therapy (doses of systemic glucocorticoids, pulse therapy with methylprednisolone). Patients with desaturation during exercise had a more severe course of the disease with a large amount of lung tissue damage, as well as higher laboratory indicators of the activity of the inflammatory process. It was also found that patients who desaturate during the exercise test more often required oxygen therapy during hospitalization, more often pulse therapy with methylprednisolone was performed.Conclusion. Patients with COVID-19 develop a decrease in physical performance, which is multifactorial. These include respiratory failure due to lung tissue damage, muscle weakness, nervous system damage (anxiety, depression), and systemic inflammation, which characterizes the severity of the infection and the associated immune response. The results of 6MWT may have a certain prognostic value in terms of the severity of the course of the disease, the severity of systemic inflammation, the need for oxygen therapy, and pulse therapy with glucocorticoids.
Biliary tract dysfunctions: Possibilities of combined drugs of plant origin as advantage therapy
Authors: Trukhan D. I. , Rozhkova M. Yu. , Samoilova Iu. G. , Oleynik O. A. , Matveeva M. V. 
Published: June 2024

Introduction. Non-alcoholic fatty liver disease (NAFLD) is caused by excess accumulation of fats in hepatocytes. An increasing percentage of adipose tissue is associated with chronic inflammation and developing oxidative stress. These pathological conditions can lead to the progression of steatosis to steatohepatitis with the further development of fibrosis and cirrhosis.Aim. To evaluate the indicators of lipid peroxidation and antioxidant defence factors in steatosis and steatohepatitis in patients with NAFLD.Materials and methods. During the work, 116 patients with NAFLD were examined, of which 65 had steatosis, and 51 had steatohepatitis. The study of biochemical markers of metabolism of proteins, fats and carbohydrates was performed on a Mindray BS-380 biochemical analyzer. The indicators of the LPO-AOD system (MDA, SOD, catalase, ceruloplasmin) were assessed using spectrophotometric methods. Statistical data processing was carried out in the STATISTICA and SPSS 26 programs using nonparametric tests.Results. Patients with steatohepatitis had more severe dyslipidemia, blood triglyceride, total cholesterol levels and LDL were significantly higher (p > 0.05). Impaired cholesterol metabolism was reflected by a high atherogenic index of 3.46. In patients with steatosis, changes in the lipid profile were less pronounced. No disturbances in protein and carbohydrate metabolism were detected. Increased levels of liver markers were noted only in patients with steatohepatitis. The change in the balance in the LPO- AOD system was more pronounced in patients with steatohepatitis; they had a high level of MDA, a high concentration of catalase; in patients with steatosis, only a decrease in the level of MDA and an increase in the level of ceruloplasmin were noted.Conclusion. Dyslipidemia, hepatocyte cytolysis and liver fibrosis are detected in patients with steatohepatitis. Disturbances in the LPO-AOD system have been identified in both forms of NAFLD, but in steatosis they are compensated. In steatohepatitis, disturbances in “LPO-AOD” in the form of an increase in pro-oxidants and a decrease in antioxidants cause the development of oxidative stress.
Effect of ustekinumab on extraintestinal manifestations in patients with Crohn’s disease or ulcerative colitis
Authors: Abdulganieva D. I. , Mukhametova D. D. 
Published: June 2024

This review presents the main extraintestinal manifestations (EIMs) in patients with inflammatory bowel diseases (IBD), in particular ulcerative colitis (UC) and Crohn’s disease (CD), describes the modern potential mechanisms, classification, characteristics and frequency of the main EIMs (rheumatological, skin, ophthalmological and orofacial manifestations). The issues of the mechanism of action, indications for prescribing ustekinumab are also covered in detail, the place of ustekinumab in the treatment of IBD is highlighted, the effectiveness of this drug in relation to the treatment of IBD is assessed – summarizes the results of a retrospective analysis of data from the UNITI-1, UNITI-2, IM-UNITI clinical trial program, prospective cohort studies, retrospective cohort studies and a registry study on the effect of ustekinumab on the course of various EIMs and the outcomes of immune-mediated diseases (IMDs) in patients with CD and UC. Ustekinumab is a fully monoclonal human immunoglobulin G1k that binds to the common p40 subunit of interleukin (IL)-12 and IL-23, which are actively involved not only in the development of intestinal symptoms, but are also triggers in the development of various EIMs. A review of the literature showed that ustekinumab may be effective for the treatment of EIMs in patients with UC and CD, especially in relation to dermatological and rheumatological manifestations, and is effective against psoriasis and psoriatic arthritis. A literature search of MEDLINE®, EMBASE®, BIOSIS Previews® and DERWENT® and/or other resources, including internal/external databases was conducted on April 15, 2024.
The Effects of Nicotine and Cannabinoids on Cytokines
Authors: Miller Grace , Pareek Ojas , Penman Samantha L. , Thanos Panayotis K. 
Published: June 2024

Background:
The usage of nicotine and cannabinoids has rapidly grown in popularity, leading to
increased research into how they can affect people’s health, both positively and negatively. Nicotine, Cannabidiol
(CBD), and Δ9-tetrahydrocannabinol (THC) have been shown to have significant effects on cytokine
function and inflammatory response.

Objective:
This study aimed to review and summarize the current literature on the effects of nicotine and cannabinoids
on cytokines, including interleukins, TNF, IFN, and TGF-β.

Methods:
Literature search was conducted on Medline/PubMed electronic databases utilizing the search terms
“nicotine” OR “cannabis” OR “cannabinoids” AND “cytokine” AND “inflammation” AND “stress” AND
“immune” from 11/1973 to 02/2024.

Results:
THC and CBD usage have been associated with conflicting impacts on immune response, and
observed to both exacerbate and inhibit inflammation. Nicotine has been shown to be generally proinflammatory
with regards to cytokines. These responses have been reported to have significant effects on
bodily response to inflammation-related diseases. Nicotine usage is associated with worsened outcomes for
some conditions, like chronic pain, but improved outcomes for others, like arthritis. The impacts of cannabinoid
usage tend to be more positive, exerting anti-inflammatory effects across a wide range of diseases.
Given the widespread usage of these substances, it is important to understand the nature of their consequences
on immune functions and the underlying mechanisms by which they act.

Conclusion:
This review has covered how cannabinoids and nicotine affect inflammation directly and how
these effects can be attributed to the treatment of inflammatory diseases. In summary, the existing research
studying the effects of cannabinoids and nicotine supports the major relationship between nicotine and cannabis
use and inflammatory diseases.