bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ceftriaxone-induced symptomatic cholelithiasis in a child: case report and literature review
Authors: Smerat Mohammad I , Shawer Balqis , AbuIrayyeh Bara M , Natsheh Shahd T , Diab Laila , Shahin Farah B , Manasra Mahmoud R 
Published: June 2024

Abstract
Ceftriaxone is a third-generation cephalosporin. Due to its wide range of activity and acceptable safety profile, it is frequently prescribed to paediatric patients. However, there are several documented cases of reports of uncommon adverse events, such as cholecystitis, linked to the use of ceftriaxone. This study discusses the case of an 8-year-old female patient who developed cholecystitis, an inflammation of the gallbladder, after being treated with ceftriaxone. The patient presented with right upper quadrant pain, associated with nausea. Imaging studies showed the presence of stones and shadowing sludge, leading to acute inflammation of the gallbladder. Prompt cessation of ceftriaxone and supportive treatment led to the resolution of cholecystitis and the complete disappearance of the sludge and stones. The study highlights that early identification and withdrawal of the antibiotic can lead to successful therapy and the avoidance of unnecessary surgical procedures.
Pigmentary retinal dystrophy associated with peroxisome biogenesis disorder-Zellweger syndrome spectrum
Authors: Zou Henry , Sutherland Liliya , Geddie Brooke 
Published: June 2024

Abstract
Pigmentary retinal dystrophy (PRD) is a group of inherited disorders involving the progressive degeneration of rod and cone photoreceptors and the retinal pigment epithelium (RPE), which can progress to pigmentary retinopathy (PR). We present a case of PRD in a female pediatric patient who has pathogenic variants in the PRPH2 and PEX1 genes. The patient has associated macular edema and secondary visual impairment. Treatment has included serial dexamethasone intravitreal implant injections and topical dorzolamide. The PEX1 gene mutation is associated with peroxisome biogenesis disorder-Zellweger syndrome spectrum (PBD-ZSS) and resulting retinal dystrophies. The PRPH2 mutation may play a role in macular edema and PRD, as it is implicated in macular degeneration, choroid defects, and photoreceptor dysfunction. In this case, we review multiple gene mutations playing potential etiologic roles for PRD and discuss care management.
Phytoplankton stoichiometry along the salinity gradient under limited nutrient and light supply
Authors: Orizar Iris D S , Repetti Sonja I , Lewandowska Aleksandra M 
Published: June 2024

Abstract
Ongoing climate warming alters precipitation and water column stability, leading to salinity and nutrient supply changes in the euphotic zone of many coastal ecosystems and semi-enclosed seas. Changing salinity and nutrient conditions affect phytoplankton physiology by altering elemental ratios of carbon (C), nitrogen (N) and phosphorus (P). This study aimed to understand how salinity stress and resource acquisition affect phytoplankton stoichiometry. We incubated a phytoplankton polyculture composed of 10 species under different light, inorganic nutrient ratio and salinity levels. At the end of the incubation period, we measured particulate elemental composition (C, N and P), chlorophyll a and species abundances. The phytoplankton polyculture, dominated by Phaeodactylum tricornutum, accumulated more particulate organic carbon (POC) with increasing salinity. The low POC and low particulate C:N and C:P ratios toward 0 psu suggest that the hypoosmotic conditions highly affected primary production. The relative abundance of different species varied with salinity, and some species grew faster under low nutrient supply. Still, the dominant diatom regulated the overall POC of the polyculture, following the classic concept of the foundation species.
Novel approaches for bacterial toxin neutralization; current advances and future perspectives
Authors: Doroudian M , Ardalan M A , Beheshti M , Soezi M 
Published: June 2024

Summary
This review outlines diverse strategies for neutralizing bacterial toxins which are a significant threat to human health. Effective toxin neutralization is crucial in preventing and treating bacterial infections, especially those caused by antibiotic-resistant strains. Promising approaches include using monoclonal antibodies that target toxins and combining them with agents that directly target bacteria. Aptamers, synthetic molecules that bind to specific targets, provide a rapid and tailored method for inhibiting toxin activity and detecting pathogens. Cell-membrane-coated nanoparticles mimic host cells and effectively neutralize toxins by diverting them and stimulating immune responses. These advancements have the potential to combat bacterial infections and alleviate the associated public health burden.
Symbolic Pollution and Religious Change: The Religious Imaginary of Anglo-CanadianSpiritual but Not ReligiousMillennials
Authors: Watts Galen , Reimer Sam 
Published: June 2024

AbstractIn this article, we advance a cultural sociological approach to religious change that foregrounds the role of symbolic pollution and shifting religious imaginaries. Leveraging interviews with 50 Anglo-Canadian Millennials who identify as spiritual but not religious, and ethnographic research at three field sites, we sketch a religious imaginary comprising four discourses of “religion.” According to our informants, “religion” is (1) anti-modern; (2) conservative; (3) American; and (4) colonial. Next, we draw from a combination of modern intellectual history and social histories of twentieth-century Canada to trace each of these discourses genealogically, thereby elucidating how “religion” became symbolically polluted for a large cohort of Canadian Millennials. We conclude with a discussion of the implications our account holds for secularization theory and the study of religious change more broadly.
Hungary: Unlocking wealth—a guide to maximizing benefits with Hungarian Asset Management Foundations for single-family offices
Authors: Menyhei Ákos 
Published: June 2024

Abstract
Hungarian Asset Management Foundations (AMFs) present a distinct legal entity tailored for wealth management by blending traditional trust principles with the flexibility of foundations. This article explores the evolution and significance of AMFs within the Hungarian legal framework, examining their role in wealth preservation, asset protection, and estate planning for single-family offices. Key findings reveal that AMFs offer a sophisticated platform for managing and preserving assets, with founders enjoying substantial control over foundation activities. Notably, AMFs provide a robust framework for asset protection, by ensuring separation of assets and shielding them from creditor claims. The confidentiality afforded by AMFs adds an extra layer of security, crucial for maintaining privacy in family wealth matters. Moreover, AMFs demonstrate adaptability to changing circumstances, allowing for dynamic adjustments to wealth management strategies and governance structures. This flexibility, coupled with tax efficiency and compliance mechanisms, positions AMFs as a comprehensive solution for single-family offices seeking to safeguard and grow their wealth across generations.
Algorithmic mistakes in machine-made contracts: the legal consequences of errors in automated contract formation
Authors: Frattone Cristina 
Published: June 2024

Abstract
Automated contract formation is on the rise. The legal consequences of computer errors in the conclusion of machine-made contracts are not straightforward though. This article makes three main contributions to the existing literature. First, it provides a bird’s-eye view of computer errors and proposes a taxonomy for algorithmic mistakes. Specifically, it introduces a distinction between automation mistakes and autonomy mistakes. Second, it illustrates how the rules on mistake under traditional contract law can be applied to algorithmic mistakes de iure condito. Third, and after highlighting the main shortcomings of the application of traditional contract law, it elaborates on the scope and remedial scheme of a specific provision on algorithmic mistake de iure condendo.
Chronic kidney disease in postmenopausal women is associated with tooth loss
Authors: Kim Na-Yeong , Kim Ji-Eun , Choi Choong-Ho , Chung Ki-Ho 
Published: June 2024

AbstractObjectiveMenopause is characterized by changes in reproductive hormone levels that can negatively affect bone. Chronic kidney disease (CKD) and tooth loss are also important and common health issues after menopause. This study aimed to evaluate the association between CKD and tooth loss in postmenopausal women.MethodsThe study evaluated 64,971 participants who participated in the Korean National Health and Nutrition Examination Survey (KNHANES) from 2010-2018, including postmenopausal women, aged 40 to 79 years. Participants were divided into two groups based on the number of teeth in their dentition (≥20 and <20).Main Outcome MeasuresThe association between CKD and tooth loss was analyzed using multivariate logistic regression. Age, income, education, smoking, alcohol intake, body mass index, hypertension, diabetes, annual oral examination, toothbrushing, and the use of oral care products were considered. Subgroup analyses were further conducted according to age (40-65 yr and 66-79 yr).ResultsAfter adjusting for covariates, CKD and estimated glomerular filtration rate were significantly associated with having ≥20 teeth (PT20; CKD: odds ratio [OR] 1.41, 95% confidence interval [CI] 1.04-1.90; estimated glomerular filtration rate (10 mL/min/1.73 m2): OR 0.90, 95% CI 0.86-0.94). Importantly, the association between CKD and PT20 was significant in postmenopausal women, aged 66 to 79 years (OR 1.45, 95% CI 1.05-2.01).ConclusionsIn postmenopausal women, CKD and tooth loss may be associated. The association is significant in postmenopausal women, aged 66 to 79 years.
Cognitive function and bladder health among midlife adult women in the Coronary Artery Risk Development in Young Adults (CARDIA) study
Authors: Brady Sonya S. , Arguedas Andrés , Huling Jared D. , Hellemann Gerhard , Yaffe Kristine , Lewis Cora E. , Fok Cynthia S. , Van Den Eeden Stephen K. , Markland Alayne D. 
Published: June 2024

Abstract

Objective
The aim of this study was to examine whether different aspects of women's cognitive function are associated with lower urinary tract symptoms (LUTS) and their impact.

Methods
In 2010-2011, women aged 42 to 57 years in the Coronary Artery Risk Development in Young Adults study completed different tests of cognitive function, including the Digit Symbol Substitution Test, Rey Auditory Verbal Learning Test, and Stroop test. Two years later, data on LUTS and their impact were collected. LUTS/impact, a four-level composite variable ranging from bladder health to mild, moderate, and severe LUTS/impact, was regressed on each cognitive test separately, as well as a cognitive function composite variable. The analytic sample was composed of 1,021 women with complete data.

Results
When adjusting for sociodemographic variables (age, race, education) and gynecologic/obstetric variables (parity, menopausal status, hysterectomy, hormonal use), better performance on the cognitive function composite and Digit Symbol Substitution Test were both associated with lower odds of membership to a more severe LUTS/impact category (odds ratio, 0.90 [95% confidence interval, 0.83-0.98] and 0.89 [95% confidence interval, 0.82-0.97], respectively). These associations became nonsignificant when additionally adjusting for mechanisms that might explain an association between cognitive function and LUTS/impact, including health behaviors and health conditions that may covary with cerebral and peripheral vascular health and cognitive function.

Conclusions
In this sample of midlife adult women, a modest association was found between better cognitive function and lower likelihood of LUTS/impact. Longitudinal studies are needed to further investigate the association between cognitive function and LUTS/impact, as well as potential explanatory mechanisms, particularly as women age and cognitive function varies to a greater degree.
Quality of life in postmenopausal women and its association with sarcopenia
Authors: Sriramaneni Nikitha , Selvan Chitra , Kumar S Nanda , Kalra Pramila , P Ganavi Y. , R Manjunath P. , Naushad Altaf Ali , Sourabh Sagar , U Chirag L. 
Published: June 2024

Abstract

Objectives
With the menopausal transition, there is a decline in estrogen concentration with potential health consequences affecting the quality of life. The loss of muscle mass, strength, and function, known as sarcopenia is common in postmenopausal women. The primary objective of this study is to assess the quality of life in postmenopausal women and its association with sarcopenia.

Methods
This was a cross-sectional study conducted in 106 postmenopausal women. Menopausal symptoms and risk of sarcopenia were assessed with Menopause Rating Scale (MRS) and Strength Assistance walking Rising from a chair Climbing stairs and Falls (SARC-F) questionnaires, respectively. Sarcopenia was defined and assessed according to the Asian Working Group for Sarcopenia guidelines 2019.

Results
The mean age was 59.34 ± 7.21 years and the mean age at menopause was 49.50 ± 2.67 years. The majority (80.2%) of the women had high MRS scores (≥9). The majority had mild somatic, moderate psychologic, and severe urogenital symptoms. SARC-F score was low in 85.8% of women. Most of the women (45.3%) had sarcopenia. Somatic symptoms were significant in women with sarcopenia. Urogenital symptoms were significant with greater menopausal duration. Appendicular skeletal muscle mass index was significantly less with greater menopausal duration. MRS score positively correlated with both SARC-F score and sarcopenia. Sarcopenia was significantly associated with greater menopausal duration.

Conclusions
Most of the women had moderate to severe MRS scores suggestive of a poor quality of life. The majority of the women had sarcopenia. Most of the women felt they were strong (according to SARC-F score) despite sarcopenia. Although quality of life did not differ significantly with the duration of menopause, urogenital symptoms were significantly severe with greater menopausal duration. Despite no significant association between quality of life and sarcopenia in postmenopausal women, somatic symptoms were significant in women with sarcopenia. The greater menopausal duration was associated significantly with sarcopenia.
The Hemerocallis citrina extracts ameliorate radiation-induced ferroptosis in LO2 cells through the Nrf2-xCT/GPX4 pathway
Authors: Zhu Zihao , Wang Yan , Deng Zhengzheng , Lei Pengyuan , Liu Qi , Guo Jinjing , Qing Qiancheng , Huang Bo 
Published: June 2024

Background:
Radiotherapy, a primary approach in cancer treatment, damages normal cells while targeting cancer cells. Therefore, it is crucial to identify drugs with minimal side effects, high reliability, and radioprotective effects to develop novel radiotherapy strategies. Hemerocallis citrina extracts (HCE), which are derived from plants with medicinal and culinary applications, possess antioxidative and anticancer properties.

Methods:
In this study, we investigated the radioprotective effects of HCE on LO2 cells exposed to radiation to determine whether these effects were mediated through the nuclear factor erythroid 2–related factor 2-cystine–glutamate antiporter/glutathione peroxidase 4 pathway.

Results:
Cell proliferation experiments demonstrated the radioprotective effect of HCE on LO2 cells. Western blot analysis revealed that HCE regulated B-cell lymphoma protein 2-associated X, Cleaved-caspase 3, and B-cell lymphoma protein 2, thereby inhibiting radiation-induced apoptosis, which was consistent with the flow cytometry results.

Conclusions:
Moreover, the detection of ferroptosis-related markers indicated that HCE alleviated radiation-induced ferroptosis in LO2 cells through the nuclear factor erythroid 2–related factor 2-cystine–glutamate antiporter/glutathione peroxidase 4 pathway. These findings provide a theoretical basis for the radioprotective effects of HCE on LO2 cells and offer new insights into the development of radioprotective drugs.
Image- and Impression-Based Technology in Scleral Lens Fitting for Keratoconus: Availability and Utilization
Authors: Fogt Jennifer Swingle , Schornack Muriel , Nau Cherie , Harthan Jennifer , Nau Amy , Shorter Ellen 
Published: June 2024

Objective:
Scleral lenses (SLs) can be customized using traditional diagnostic lens fitting or by using image- and/or impression-based technologies. This study describes the availability and usage of SL fitting technology in patients with keratoconus.

Methods:
An online survey queried practitioners on the mode of practice, country of residence, and estimated number of SL fits completed for keratoconus. Practitioners were asked whether they had access to image- and/or impression-based technology and to estimate the percentage of fits completed using diagnostic fitting, image-based technology, and impression-based technology. Access and usage of technology was compared between academic and community practices, United States and non–United States, and high-volume (≥60 SLs) and low-volume fitters.

Results:
423 practitioners who fit SL for keratoconus participated. Image- and impression-based technologies were more frequently available in academic practices compared with community practices and high-volume compared with low-volume practitioners (P<0.005). Practitioners with image-based technology used it for a median [interquartile range] 5 [25]% of SL fittings; those with impression-based technology used it for 8 [9]% of fittings, and those with both types of technology used image-based devices for 12 [23]% of fittings and impression-based for 5 [8]% of fittings.

Conclusions:
In this study, most participants report using diagnostic lenses to fit SLs for patients with keratoconus.
Fueling the success of transplantation through nutrition: recent insights into nutritional interventions, their interplay with gut microbiota and cellular mechanisms
Authors: Koehler Felix C. , Späth Martin R. , Meyer Anna M. , Müller Roman-Ulrich 
Published: June 2024

Purpose of review
The role of nutrition in organ health including solid organ transplantation is broadly accepted, but robust data on nutritional regimens remains scarce calling for further investigation of specific dietary approaches at the different stages of organ transplantation. This review gives an update on the latest insights into nutritional interventions highlighting the potential of specific dietary regimens prior to transplantation aiming for organ protection and the interplay between dietary intake and gut microbiota.

Recent findings
Nutrition holds the potential to optimize patients’ health prior to and after surgery, it may enhance patients’ ability to cope with the procedure-associated stress and it may accelerate their recovery from surgery. Nutrition helps to reduce morbidity and mortality in addition to preserve graft function. In the case of living organ donation, dietary preconditioning strategies promise novel approaches to limit ischemic organ damage during transplantation and to identify the underlying molecular mechanisms of diet-induced organ protection. Functioning gut microbiota are required to limit systemic inflammation and to generate protective metabolites such as short-chain fatty acids or hydrogen sulfide.

Summary
Nutritional intervention is a promising therapeutic concept including the pre- and rehabilitation stage in order to improve the recipients’ outcome after solid organ transplantation.
Reexploring cytomegalovirus serology in allogeneic hematopoietic cell transplantation
Authors: Royston Léna , Neofytos Dionysios 
Published: June 2024

Purpose of reviewDiscuss the recent evidence on cytomegalovirus (CMV) serology in allogeneic hematopoeic cell transplant (HCT) recipients.Recent findingsWhereas the role CMV-specific cellular mediated immunity has recently emerged as an important factor of CMV DNAemia posttransplant, the value of CMV serology has remained unchanged through decades, associated with donor selection and posttransplant prophylactic and monitoring strategies. In this review, we describe and discuss the emerging reports on the association between the magnitude of pretransplant CMV immunoglobulin G (IgG) titer and the posttransplant incidence of CMV DNAemia, as CMV IgG titer could become an additional tool in CMV risk assessment in the future.SummaryPretransplant recipient CMV serology may have significant implications in posttransplant CMV reactivation in allogeneic HCT recipients.
Intraureteral Metastasis From Colon Cancer Mimicking Primary Ureteral Carcinoma on FDG PET/CT
Authors: Ji Xia , Dong Aisheng , Zhu Yan 
Published: June 2024

AbstractHematogenous or lymphatic intraureteral metastasis from distant primary cancer is very rare. We present contrast-enhanced CT and FDG PET/CT findings in a case of intraureteral metastasis from colonic adenocarcinoma 3 years after colectomy. The intraureteral showed moderate enhancement on contrast-enhanced CT and increased FDG uptake on PET/CT mimicking a primary ureteral carcinoma. This case suggests that metastatic tumor of the ureter should be considered in the differential diagnosis in patients with hypermetabolic ureteral lesion and known malignancy.
The Maxillary Nerve Block in Cleft Palate Care: A Review of the Literature and Expert’s Opinion on the Preferred Technique of Administration
Authors: Peters Jess J. , Jacobs Karl , Munill Montserrat , Top Anke P.C. , Stevens Markus F. , Ronde Elsa M. , Don Griot J. Peter W. , Lachkar Nadia , Breugem Corstiaan C. 
Published: June 2024

Introduction:
Although the maxillary nerve block (MNB) provides adequate pain relief in cleft palate surgery, it is not routinely used globally, and reported techniques are heterogeneous. This study aims to describe relevant anatomy and to present the preferred technique of MNB administration based on the current literature and the expert opinion of the authors.

Method and materials:
First, a survey was sent to 432 registrants of the International Cleft Palate Master Course Amsterdam 2023. Second, MEDLINE (PubMed interface) was searched for relevant literature on maxillary artery (MA) anatomy and MNB administration in pediatric patients.

Results:
Survey response rate was 18% (n=78). Thirty-five respondents (44.9%) used MNB for cleft palate surgery before the course. A suprazygomatic approach with needle reorientation towards the ipsilateral commissure before incision was most frequently reported, mostly without the use of ultrasound. Ten and 20 articles were included on, respectively, MA anatomy and MNB administration. A 47.5% to 69.4% of the MA’s run superficial to the lateral pterygoid muscle and 32% to 52.5% medially. The most frequently described technique for MNB administration is the suprazygomatic approach. Reorientation of the needle towards the anterior aspect of the contralateral tragus appears optimal. Needle reorientation angles do not have to be adjusted for age, unlike needle depth. The preferred anesthetics are either ropivacaine or (levo)bupivacaine, with dexmedetomidine as an adjuvant.

Conclusion:
Described MNB techniques are heterogeneous throughout the literature and among survey respondents and not routinely used. Further research is required comparing different techniques regarding efficacy and safety.