bluuebunny/crossref_metadata_2025_split huggingface dataset:
Einsatz von Antibiotikum zur perioperativen Infektprophylaxe in der
elektiven Handgelenksarthroskopie: Eine deutschlandweite
Befragung
Authors: Demmer Wolfram , Meyer Emanuel , Volkmer Elias , Ehrl Denis , Haas-Lützenberger Elisabeth M. , Kuhlmann Constanze , Giunta Riccardo E. , Wachtel Nikolaus 
Published: April 2024

Zusammenfassung
Hintergrund Die Handgelenksarthroskopie (HG-ASK) ist ein handchirurgisches
Standardverfahren zur Diagnose und Behandlung von Handgelenksbeschwerden. Obwohl
für elektive handchirurgische Eingriffe die perioperative Antibiotikagabe zur
Infektprophylaxe (PAP) nicht allgemein empfohlen wird, gibt es bezüglich der
elektiven HG-ASK keinen offiziellen Standard. In dieser Studie sollte daher die
tatsächliche klinische Anwendung von PAP bei elektiven HG-ASK in Deutschland
ermittelt und in Bezug zu den strukturellen Voraussetzungen der durchführenden
Kliniken gesetzt werden.
Material und Methoden Es wurde eine systematische Recherche aller
Einrichtungen in Deutschland, die HG-ASK anbieten, durchgeführt. Unter diesen
wurde eine Online-Umfrage mit dem Online-Tool SoSci Survey per E-mail
durchgeführt.
Ergebnisse Von 396 befragten Einrichtungen nahmen 84 (21,2%) an der
Umfrage teil. Eine PAP wird häufiger bei gleichzeitigen Eingriffen an Knochen
verabreicht. Im Falle einer PAP-Gabe werden Cephalosporine mit Abstand am
häufigsten verwendet. In Krankenhäusern wird häufiger PAP verabreicht als in der
ambulanten Versorgung, wobei sich die meisten befragten Institutionen bei der
Antibiotikagabe an einrichtungsspezifischen internen Standards orientieren. Die
Anzahl der durchgeführten Arthroskopien in den befragten Zentren hat keinen
Einfluss auf die Antibiotikagabe.
Schlussfolgerungen Die Anwendung von PAP bei Handgelenksarthroskopien ist
in Deutschland uneinheitlich. Die vermehrte Anwendung bei Arthroskopien mit
knöcherner Beteiligung entspricht den AWMF-Leitlinien, eine generelle Empfehlung
zu Handgelenksarthroskopien inklusive Weichteilarthroskopien ist aber notwendig,
um den behandelnden Ärzten Behandlungs- und medizinrechtliche Sicherheit zu
geben.
Hepatitis E and diaphragmatic dysfunction: Case series and review of the literature
Authors: Westhoff Michael , Arias Andres , Litterst Patric 
Published: April 2024

Abstract
Introduction The causes of diaphragmatic paresis are manifold. An association between neuralgic amyotrophy (NA) and hepatitis E virus (HEV) infection has been reported. We wondered about the prevalence of diaphragmatic disfunction and hepatitis E infection in our clinic.

Methods From July 1st, 2020 to August 31st, 2023, patients presenting with diaphragmatic dysfunction and simultaneous clinical symptoms of an acute NA, or a history of NA, as well as patients with previously unexplained diaphragmatic dysfunction were examined for HEV infection.

Results By August 31st, 2023, 13 patients with diaphragmatic dysfunction and HEV infection were diagnosed (4 women, 9 men). Mean age was 59 ± 10 years. Liver values were normal in all patients. The median latency to diagnosis was five months (range: 1–48 months); nine patients, 4 of them with typical symptoms of NA, presented with acute onset three patients showed bilateral diaphragmatic dysfunction. All patients had a positive IgG immunoblot. Seven patients, three with NA, had an elevated hepatitis E IgM titer and six of them also a positive IgM immunoblot. In all cases, O2C hepatitis genotype 3 was identified. In eight cases, all those with a high IgG titer >125, the O2 genotype 1 was also detected.

Conclusion NA that shows involvement of the phrenic nerve resulting in diaphragmatic dysfunction and dyspnoea, may be associated with HEV infection. The observation of 13 patients with diaphragmatic dysfunctions and HEV infection within a period of three years indicates a high number of undetected HEV-associated diaphragmatic dysfunction in the population, especially in the absence of NA symptoms. Therefore, even in diaphragmatic dysfunction without NA symptoms and causative damaging event, HEV infection should be considered, as it may represent a subform of NA with only phrenic nerve involvement. Therapy of HEV-associated diaphragmatic dysfunction in the acute phase is an open question. In view of the poor prognosis for recovery, antiviral therapy should be discussed. However, no relevant data are currently available.
Síndrome de aprisionamento da artéria poplítea como diagnóstico diferencial de dor no joelho: Um relato de caso
Authors: Rosa Antuny Rodrigues , Cé Hamilton Santos , Marchini Ana Clara Monteiro , Lopetegui Anna Katarina Menegon , Padilha Anna Luiza Lunardelli , Bianchini Gustavo Rosa 
Published: April 2024

ResumoA síndrome do aprisionamento da artéria poplítea possui causas congênitas e funcionais, acometendo, em grande parte, a população mais jovem. Existem seis tipos de síndrome, sendo o caso relatado classificado como tipo III, isto é, o músculo gastrocnêmio apresenta variação anatômica, com banda acessória que se insere lateralmente no côndilo femoral, comprimindo a artéria poplítea. A paciente apresentou sintomatologia característica, com claudicação intermitente, parestesia e ausência de fluxo sanguíneo nas artérias tibiais posteriores e pediosas quando submetida à dorsiflexão e flexão plantar do pé direito, além de dor em face posterior do joelho durante a realização do exame físico. O diagnóstico foi complementado por exames de imagem, sendo o método de escolha a ressonância magnética, capaz de identificar alterações vasculares nas estruturas adjacentes à vasculatura na fossa poplítea. O tratamento é cirúrgico e visa tanto o alívio dos sintomas quanto a prevenção de complicações, pois, a ressecção da banda acessória do músculo gastrocnêmio permitiu boa evolução do quadro da paciente. Há que se pontuar que a literatura existente sobre o tema é escassa, mas a conduta adotada no caso em questão converge com as demais publicações encontradas. O relato apresentado é importante para a compreensão da síndrome como diagnóstico diferencial da dor no joelho.
Phenotypic Variability Related to Mutations in Riboflavin Transporter in Brazilian Children: Pediatric Case Series
Authors: Marques Izabela Cristina Macedo , Santos Mara Lúcia Schmitz Ferreira , Fidalski Solena Ziemer Kusma , de Souza Josiane , do Valle Daniel Almeida 
Published: April 2024

AbstractBrown–Vialetto–Van Laere syndrome or riboflavin transporter deficiency is a rare and genetically determined condition that results in a spectrum of neurological signs and symptoms from generalized muscle weakness to cranial nerve involvement with medullary symptoms and respiratory failure. Most patients have SLC52A3 gene biallelic variants, but some of them may have impairment of SLC52A2 gene, both related to the cell transport of riboflavin. We report the case of three unrelated Brazilian patients under 18 years of age with this diagnosis confirmed by molecular genetic sequencing. We observed that the clinical manifestations found were compatible with those already described in the literature by age group. Unusual findings of retinitis pigmentosa and immunodeficiency were identified related to pathogenic variants in the SLC52A2 gene. All patients received riboflavin replacement at a therapeutic dose without gastrointestinal intolerance and with clinical improvement after starting treatment.
Spectral characteristics of laser-plasma instabilities with a broadband laser
Authors: Xu 许 Guo-Xiao 国潇 , Kang 康 Ning 宁 , Lei 雷 An-Le 安乐 , Liu 刘 Hui-Ya 会亚 , Zhao 赵 Yao 耀 , Zhou 周 Shen-Lei 申蕾 , An 安 Hong-Hai 红海 , Xiong 熊 Jun 俊 , Wang 王 Rui-Rong 瑞荣 , Xie 谢 Zhi-Yong 志勇 , Zhou 周 Xi-Chen 熙晨 , Fang 方 Zhi-Heng 智恒 , Wang 王 Wei 伟 
Published: April 2024

Abstract
Recent experimental progresses regarding broadband laser-plasma instabilities (LPIs) show that a 0.6% laser bandwidth can reduce backscatters of the stimulated Brillouin scattering (SBS) and the stimulated Raman scattering (SRS) at normal incidence [Phys. Rev. Lett.
132 035102 (2024)]. In this paper, we present a further discussion of the spectral distributions of the scatters developed by broadband LPIs, in addition to a brief validation of the effectiveness of bandwidth on LPIs mitigation at oblique incidence. SBS backscatter has a small redshift in the broadband case contrary to the blueshift with narrowband laser, which may be explained by the self-cross beam energy transfer between the various frequency components within the bandwidth. SRS backscatter spectrum presents a peak at a longer wavelength in the broadband case compared to the short one in the narrowband case, which is possibly attributed to the mitigation effect of bandwidth on filaments at underdense plasmas. The three-halves harmonic emission (3ω/2) has a one-peak spectral distribution under the broadband condition, which is different from the two-peak distribution under the narrowband condition, and may be related to the spectral mixing of different frequency components within the bandwidth if the main sources of the two are both two-plasmon decays.
Systematic investigation of nucleon optical model potentials in (p, d) transfer reactions*
Authors: Chen 陈 Silu 思璐 , Liu 刘 Zixuan 子旋 , Zhang 张 Zhi 智 , Xu 续 Ruirui 瑞瑞 , Pang 庞 Danyang 丹阳 , Xu 许 Yiping 祎萍 
Published: April 2024

Abstract
The consistent three-body model reaction methodology (TBMRM) proposed by J. Lee et al. [ Phys. Rev. C 69, 064313 (2004); Phys. Rev. C 73, 044608 (2006); Phys. Rev. C 75, 064320 (2007)], which includes adopting the simple zero-range adiabatic wave approximation, constraining the single-particle potentials using modern Hartree–Fock calculations, and using global nucleon optical model potential (OMP) geometries, are widely applied in systematic studies of transfer reactions. In this study, we investigate the influence of different nucleon OMPs in extracting spectroscopic factors (SFs) from (

) reactions. Our study covers 32 sets of angular distribution data of (

) reactions on four targets and a large range of incident energies (20-200 MeV/nucleon). This study uses two semi-microscopic nucleon OMPs, i.e., Jeukenne, Lejeune, and Mahaux (JLM) [Phys. Rev. C 16, 80 (1977); Phys. Rev. C 58, 1118 (1998)] and CTOM [Phys. Rev. C 94, 034606 (2016)], and a pure microscopic nucleon potential, i.e., WLH [Phys. Rev. Lett. 127, 182502 (2021)]. The results are compared with those using the phenomenological global optical potential KD02 [Nucl. Phys. A 713, 231 (2003)]. We find that the incident energy dependence of spectroscopic factors extracted from (

) reactions is evidently suppressed when microscopic OMPs are employed for 12C, 28Si, and 40Ca. In addition, spectroscopic factors extracted using the systematic microscopic optical potential CTOM based on the Dirac-Brueckner-Hartree-Fock theory are more in line with the results obtained from (

) measurements, except for 16O and 40Ca at high energies (> 100 MeV), necessitating an exact treatment of double-magic nuclei. The results obtained by using the pure microscopic optical potential, WLH, based on the EFT theory show the same trend as those of CTOM but are generally higher. The JLM potential, which relies on simplified nuclear matter calculations with old-fashioned bare interactions, produces results that are very similar to those of the phenomenological potential KD02. Our results indicate that modern microscopic OMPs are reliable tools for probing the nuclear structure using transfer reactions across a wide energy range.
Stress spatial distributions, the Gutenberg–Richter and Omori–Utsu laws
Authors: Pétrélis François , Chanard Kristel , Schubnel Alexandre , Hatano Takahiro 
Published: April 2024

AbstractWe investigate several earthquake models in one and two dimensions of space and analyze in these models the stress spatial distribution. We show that the statistical properties of stress distribution are responsible for the distribution of earthquake magnitudes, as described by the Gutenberg–Richter (GR) law. A series of predictions is made based on the analogies between the stress profile and one-dimensional random curves or two-dimensional random surfaces. These predictions include theb-value, which determines the ratio of small to large seismic events and, in two-dimensional models, we predict the existence of aftershocks and their temporal distribution, known as the Omori–Utsu law. Both the GR and Omori–Utsu law are properties which have been extensively validated by earthquake observations in nature.
Hybrid designs and kick-off batch production experience for the CMS Phase-2 Upgrade
Authors: Kovacs M. , Abbas M. , Ahmed I. , Blanchot G. , Honma A. , La Rosa A. , Mateos Dominguez I. , Klein K. , Mohammadi Najafabadi M. , Schleidweiler K. , Szydlik P. , Zografos A. ,   the CMS collaboration
Published: April 2024

Abstract
The CMS Tracker Phase-2 Upgrade requires the production of new sensor modules to cope with the requirements of the HL-LHC. The two main building blocks of the Outer Tracker are the Strip-Strip and Pixel-Strip modules. All-together 47'520 hybrid circuits will be produced to construct 8'000 Strip-Strip and 5'880 Pixel-Strip modules. The circuit designs for the mass production were fine-tuned and kick-off batches were manufactured to verify the latest changes in the designs before the series production. This contribution focuses on lessons learned from the prototyping stage, design optimization details for the mass production as well as test results and production yield from the kick-off batches.
Characterisation of Redlen HF-CdZnTe at > 106 ph s-1 mm-2 using HEXITECMHz
Authors: Cline B.D. , Banks D. , Bell S. , Church I. , Davis A. , Gardiner T. , Harris J. , Hart M. , Jones L. , Nicholls T. , Nobes J. , Pradeep S. , Roberts M. , Sole D. , Veale M.C. , Wilson M.D. , Dhamgaye V. , Fox O. , Sawhney K. 
Published: April 2024

Abstract
In this paper, results are presented from the
characterisation of Redlen Technologies high-flux-capable Cadmium
Zinc Telluride (HF-CZT) hybridised to the HEXITECMHz
ASIC, a novel 1 MHz continuous X-ray imaging system. A 2 mm thick
HF-CZT HEXITECMHz detector was characterised on the B16
Test Beamline at the Diamond Light Source and displayed an average
FWHM of 850 eV for monochromatic X-rays of energy
20 keV. Measurements revealed a shift in the baseline of
irradiated pixels that results in a movement of the entire spectrum
to higher ADU values. Datasets taken to analyse the effect's
dynamics showed it to be highly localised and flux-dependent, with
the excess leakage current generated equivalent to per-pixel shifts
of ∼ 543 pA (8.68 nA mm-2) at a flux of
1.26×107 ph s-1 mm-2. Comparison to results
from a p-type Si HEXITECMHz device indicate this `excess
leakage-current' effect is unique to HF-CZT and it is hypothesised
that it originates from trapping at the electrode-CZT interface and
a temporary modification of the potential barrier between the CZT
and metal electrode.
Dimensional accuracy of acrylonitrile butadiene styrene and polylactic acid samples printed in vacuum-assisted material extrusion system
Authors: Shahrum Mohd Afiq , Rajendran Thavinesh Kumar , Maidin Shajahan , Azri Mohd Asyraf , Ismail Shafinaz , Kamarulnizam Mohd 
Published: April 2024

Abstract
This paper discusses the impact of integrating a vacuum system into a material extrusion 3D printing process for acrylonitrile butadiene styrene (ABS) and polylactic acid (PLA) materials. The study aimed to investigate the effect of a vacuum system on the dimensional accuracy of the printed samples. Upon completion of the printing process, the samples’ dimensions were carefully assessed using a Coordinate Measuring Machine (CMM). The geometrical dimensions measured are the diameter, corner radius, fillet, thickness, width, length and angle. Based on the result obtained, the material has yet to reach 100% of the desired geometry, which was identified due to the shrinkage of the material after the printing process. The results show that the vacuum system improved material flow and reduced dimensional deviations by reducing air molecules and minimizing convection. The results indicated a significant enhancement in dimensional accuracy for both ABS and PLA samples when using the vacuum system. ABS samples showed a 4% increase in accuracy, while PLA samples exhibited a 2% improvement compared to samples printed without vacuum assistance. These improvements were achieved by optimizing process parameters such as layer height (0.15 mm), infill percentage (10%), printing speed (45 mm s−1), and bed temperature (60 °C). These parameters were selected to ensure finer details, improved precision, structural support, stability, better adhesion, and reduced warping.
Enhancing photovoltaic energy forecasting: a progressive approach using wavelet packet decomposition
Authors: Ferkous Khaled , Guermoui Mawloud , Bellaour Abderahmane , boulmaiz Tayeb , Bailek Nadjem 
Published: April 2024

Abstract
Accurate photovoltaic (PV) energy forecasting plays a crucial role in the efficient operation of PV power stations. This study presents a novel hybrid machine-learning (ML) model that combines Gaussian process regression with wavelet packet decomposition to forecast PV power half an hour ahead. The proposed technique was applied to the PV energy database of a station located in Algeria and its performance was compared to that of traditional forecasting models. Performance evaluations demonstrate the superiority of the proposed approach over conventional ML methods, including Gaussian process regression, extreme learning machines, artificial neural networks and support vector machines, across all seasons. The proposed model exhibits lower normalized root mean square error (nRMSE) (2.116%) and root mean square error (RMSE) (208.233 kW) values, along with a higher coefficient of determination (R2) of 99.881%. Furthermore, the exceptional performance of the model is maintained even when tested with various prediction horizons. However, as the forecast horizon extends from 1.5 to 5.5 hours, the prediction accuracy decreases, evident by the increase in the RMSE (710.839 kW) and nRMSE (7.276%), and a decrease in R2 (98.462%). Comparative analysis with recent studies reveals that our approach consistently delivers competitive or superior results. This study provides empirical evidence supporting the effectiveness of the proposed hybrid ML model, suggesting its potential as a reliable tool for enhancing PV power forecasting accuracy, thereby contributing to more efficient grid management.
Transmissible cancers, the genomes that do not melt down
Authors: Bramwell Georgina , DeGregori James , Thomas Frédéric , Ujvari Beata 
Published: April 2024

Abstract
Evolutionary theory predicts that the accumulation of deleterious mutations in asexually reproducing organisms should lead to genomic decay. Clonally reproducing cell lines, i.e., transmissible cancers, when cells are transmitted as allografts/xenografts, break these rules and survive for centuries and millennia. The currently known 11 transmissible cancer lineages occur in dogs (canine venereal tumour disease), in Tasmanian devils (devil facial tumor diseases, DFT1 and DFT2), and in bivalves (bivalve transmissible neoplasia). Despite the mutation loads of these cell lines being much higher than observed in human cancers, they have not been eliminated in space and time. Here, we provide potential explanations for how these fascinating cell lines may have overcome the fitness decline due to the progressive accumulation of deleterious mutations and propose that the high mutation load may carry an indirect positive fitness outcome. We offer ideas on how these host–pathogen systems could be used to answer outstanding questions in evolutionary biology. The recent studies on the evolution of these clonal pathogens reveal key mechanistic insight into transmissible cancer genomes, information that is essential for future studies investigating how these contagious cancer cell lines can repeatedly evade immune recognition, evolve, and survive in the landscape of highly diverse hosts.
Detection of rare variants among nuclei populating the arbuscular mycorrhizal fungal model species Rhizophagus irregularis DAOM197198
Authors: Manyara David , Sánchez-García Marisol , Montoliu-Nerin Merce , Rosling Anna 
Published: April 2024

Abstract
Identifying genuine polymorphic variants is a significant challenge in sequence data analysis, although detecting low-frequency variants in sequence data is essential for estimating demographic parameters and investigating genetic processes, such as selection, within populations. Arbuscular mycorrhizal (AM) fungi are multinucleate organisms, in which individual nuclei collectively operate as a population, and the extent of genetic variation across nuclei has long been an area of scientific interest. In this study, we investigated the patterns of polymorphism discovery and the alternate allele frequency distribution by comparing polymorphism discovery in 2 distinct genomic sequence datasets of the AM fungus model species, Rhizophagus irregularis strain DAOM197198. The 2 datasets used in this study are publicly available and were generated either from pooled spores and hyphae or amplified single nuclei from a single spore. We also estimated the intraorganismal variation within the DAOM197198 strain. Our results showed that the 2 datasets exhibited different frequency patterns for discovered variants. The whole-organism dataset showed a distribution spanning low-, intermediate-, and high-frequency variants, whereas the single-nucleus dataset predominantly featured low-frequency variants with smaller proportions in intermediate and high frequencies. Furthermore, single nucleotide polymorphism density estimates within both the whole organism and individual nuclei confirmed the low intraorganismal variation of the DAOM197198 strain and that most variants are rare. Our study highlights the methodological challenges associated with detecting low-frequency variants in AM fungal whole-genome sequence data and demonstrates that alternate alleles can be reliably identified in single nuclei of AM fungi.
Skeletal consequences of preterm birth in pigs as a model for preterm infants
Authors: Wilson Brittany M , Ko Frank C , Moran Meghan M , Adra Amal , Rasmussen Martin B , Thymann Thomas , Sangild Per T , Sumner Dale Rick 
Published: April 2024

Abstract
Preterm birth affects about 10% of all live births with many resultant health challenges, including metabolic bone disease of prematurity (MBDP), which is characterized by elevated alkaline phosphatase, suppressed phosphate, and deficient skeletal development. Because of the lack of an animal model, very little is known about bone structure, strength, and quality after preterm birth. This study investigated the utility of a pig model to replicate clinical features of preterm birth, including MBDP, and sought to determine if early postnatal administration of IGF-1 was an effective treatment. Preterm pigs, born by caesarean section at 90% gestation, were reared in intensive care facilities (respiratory, thermoregulatory, and nutritional support) and compared with sow-reared term pigs born vaginally. Preterm pigs were systemically treated with vehicle or IGF-1 (recombinant human IGF-1/BP-3, 2.25 mg/kg/d). Tissues were collected at postnatal days 1, 5, and 19 (the normal weaning period in pigs). Most bone-related outcomes were affected by preterm birth throughout the study period, whereas IGF-1 supplementation had almost no effect. By day 19, alkaline phosphatase was elevated, phosphate and calcium were reduced, and the bone resorption marker C-terminal crosslinks of type I collagen was elevated in preterm pigs compared to term pigs. Preterm pigs also had decrements in femoral cortical cross-sectional properties, consistent with reduced whole-bone strength. Thus, the preterm pig model replicates many features of preterm bone development in infants, including features of MBDP, and allows for direct interrogation of skeletal tissues, enhancing the field’s ability to examine underlying mechanisms.