bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Review of Near-Collision Driver Behavior Models
Authors: Markkula Gustav , Benderius Ola , Wolff Krister , Wahde Mattias 
Published: June 2012

Objective: This article provides a review of recent models of driver behavior in on-road collision situations. Background: In efforts to improve traffic safety, computer simulation of accident situations holds promise as a valuable tool, for both academia and industry. However, to ensure the validity of simulations, models are needed that accurately capture near-crash driver behavior, as observed in real traffic or driving experiments. Method: Scientific articles were identified by a systematic approach, including extensive database searches. Criteria for inclusion were defined and applied, including the requirement that models should have been previously applied to simulate on-road collision avoidance behavior. Several selected models were implemented and tested in selected scenarios. Results: The reviewed articles were grouped according to a rough taxonomy based on main emphasis, namely avoidance by braking, avoidance by steering, avoidance by a combination of braking and steering, effects of driver states and characteristics on avoidance, and simulation platforms. Conclusion: A large number of near-collision driver behavior models have been proposed. Validation using human driving data has often been limited, but exceptions exist. The research field appears fragmented, but simulation-based comparison indicates that there may be more similarity between models than what is apparent from the model equations. Further comparison of models is recommended. Application: This review provides traffic safety researchers with an overview of the field of driver models for collision situations. Specifically, researchers aiming to develop simulations of on-road collision accident situations can use this review to find suitable starting points for their work.
Examining the Interaction of Force and Repetition on Musculoskeletal Disorder Risk
Authors: Gallagher Sean , Heberger John R. 
Published: June 2012

Objective: Our aims were (a) to perform a systematic literature review of epidemiological studies that examined the interaction of force and repetition with respect to musculoskeletal disorder (MSD) risk, (b) to assess the relationship of force and repetition in fatigue failure studies of musculoskeletal tissues, and (c) to synthesize these findings. Background: Many epidemiological studies have examined the effects of force and repetition on MSD risk; however, relatively few have examined the interaction between these risk factors. Method: In a literature search, we identified 12 studies that allowed evaluation of a force-repetition interaction with respect to MSD risk. Identified studies were subjected to a methodological quality assessment and critical review. We evaluated laboratory studies of fatigue failure to examine tissue failure responses to force and repetition. Results: Of the 12 epidemiological studies that tested a Force × Repetition interaction, 10 reported evidence of interaction. Based on these results, the suggestion is made that force and repetition may be interdependent in terms of their influence on MSD risk. Fatigue failure studies of musculoskeletal tissues show a pattern of failure that mirrors the MSD risk observed in epidemiological studies. Conclusions: Evidence suggests that there may be interdependence between force and repetition with respect to MSD risk. Repetition seems to result in modest increases in risk for low-force tasks but rapid increases in risk for high-force tasks. This interaction may be representative of a fatigue failure process in affected tissues.
An Objective Approach to Identifying Diagnostic Expertise Among Power System Controllers
Authors: Loveday Thomas , Wiggins Mark W. , Harris Jemma M. , O’Hare David , Smith Neil 
Published: June 2012

Objective: The present study investigated whether performance across a range of cue-based cognitive tasks differentiated the diagnostic performance of power control operators into three distinct groups, characteristic of novice, competence, and expertise. Background: Despite its increasing importance in the contemporary workplace, there is little understanding of the cognitive processes that distinguish novice, competent, and expert performance in the context of remote diagnosis. However, recent evidence suggests that cue acquisition and utilization may represent a mechanism by which the transition from novice to expertise occurs. Method: The study involved the application of four distinct cue-based tasks within the context of power system control. A total of 65 controllers, encompassing a range of industry experience, completed the tasks as part of an in-service training program. Results: Using a cluster analysis, it was possible to extract three distinct groups of operators on the basis of their performance in the cue-based tasks, and these groups corresponded to differences in diagnostic performance. Conclusion: The results indicate assessments of the capacity to extract and utilize cues were able to distinguish expert from competent practitioners in the context of power control. Application: Assessments of the capacity to extract and utilize cues may be used in the future to distinguish expert from nonexpert practitioners, particularly in the context of remote diagnosis.
Acute psychiatric treatment and the use of physical restraint in first-generation immigrants in Italy: A prospective concurrent study
Authors: Tarsitani Lorenzo , Pasquini Massimo , Maraone Annalisa , Zerella Maria Paola , Berardelli Isabella , Giordani Roberta , Polselli Gian Marco , Biondi Massimo 
Published: June 2012

Background and Aims: Immigrants in Europe appear at higher risk of psychiatric coercive interventions. No studies have investigated this issue in Italy. The aim of this study is to investigate whether the use of physical restraint, compulsory admission and other treatment characteristics differ in immigrated and Italian-born patients admitted to a psychiatric intensive care unit. Methods: One hundred first-generation immigrant patients were compared to 100 age-, gender- and diagnosis-matched Italian-born patients. Subjects were diagnosed according to DSM-IV-TR and rated on the Clinical Global Impression – Severity Scale and the Global Assessment of Functioning. Clinical data and treatment characteristics were collected. Results: Immigrant patients were more likely to be physically restrained as compared to Italian-born patients (11% vs 3%; χ 2 = 4.92; p = 0.027; RR = 3.67; 95% CI = 1.05–12.7). No differences in the proportion of involuntary treatment were found. Immigrant patients did not receive higher doses of antipsychotics or benzodiazepines, but they had a longer stay in the hospital. Conclusions: The higher rate of physical restraint among migrants may reflect cultural, ethnic and language differences leading to communication problems between immigrant patients and mental health professionals. Since coercive interventions can be harmful, specific strategies to prevent this phenomenon in immigrants are needed.
Characteristics of Chinese rural young suicides by pesticides
Authors: Zhang Jie , Li Ziyao 
Published: June 2012

Background: The major suicide method in rural China today is ingestion of agricultural pesticides. Aim: This study is to investigate the characteristics of Chinese rural young suicides who died of pesticide ingestion. Methods: A sample of 392 suicides from rural China was studied using the psychological autopsy method, and data were analysed for demographic characteristics, the suicide method used, mental disorder and psychological characteristics. Results: Suicides by pesticide ingestion were enacted more because of impulsiveness and tended to demonstrate less mental illness than those suicides using other means in rural China. Conclusions: Accessibility, high toxicity and lethality of the pesticides were risk factors for the suicides of people without a mental disorder in rural China. The use of pesticides is a rational choice and the safe storage of these kinds of farming chemicals should be controlled to prevent certain suicides.
Detoxification of medication-overuse headache by a multidisciplinary treatment programme is highly effective: A comparison of two consecutive treatment methods in an open-label design
Authors: Munksgaard Signe B , Bendtsen Lars , Jensen Rigmor H 
Published: June 2012

Background: Evidence for optimal medication-overuse headache treatment is lacking. Some experts suggest reduced symptomatic medication with prophylactics from the start of withdrawal, while others suggest a two-month drug-free period with multidisciplinary education. Aim: To examine the acceptability, feasibility and outcome of these two regimes in a non-randomised open-label study. Methods: Patients able to undergo outpatient detoxification, with medication-overuse headache that had previously been unsuccessfully treated by specialists and without significant co-morbidities were treated with (A) individual withdrawal with restricted symptomatic medication and prophylactics from Day 1 or (B) a two-month drug-free period and multidisciplinary education in groups. All patients received close one-year follow-up. Results: Eighty-six of 98 patients completed follow-up. Both treatments proved highly effective—80.0% of Group A and 85.4% of Group B were cured of medication-overuse headache. Headache-frequency reduction was 40.2% in Group A and 38.4% in group B. In 48.9% of group A and 48.8% of group B, headache-frequency reduction was >50%. Programme B required fewer resources from the staff and only 61.9% of these patients needed prophylactics after two months compared with 84.8% in programme A. Conclusions: Both structured detoxification programmes proved highly effective with one-year close follow-up in previously treatment-resistant patients with medication-overuse headache. We suggest multidisciplinary education for patients in groups and delaying initiation of prophylactics until after the detoxification.
A proposal for revision of hemicrania continua diagnostic criteria based on critical analysis of 62 patients
Authors: Prakash Sanjay , Golwala Purva 
Published: June 2012

Background: Misdiagnosis of hemicrania continua (HC) is common. It is diagnosed according to the criteria of the International Headache Society (IHS), but in clinical practice, these criteria seem too restrictive and many hemicrania continua-like headaches remain unclassified. Subjects and methods: We retrospectively studied the patients fulfilling the IHS criteria for HC. In addition, we identified a group of patients who met all criteria minus cranial autonomic features (HC-A) or minus a complete response to indomethacin (HC-I). We compared epidemiological profiles, clinical features and therapeutic responses to drug(s) between the groups. In addition, we reviewed the literature and critically analysed the diagnostic criteria for HC. Results: Sixty-two patients with a putative diagnosis of HC were identified. Thirty patients (48%) fulfilled the IHS criteria for HC. Thirty-two (52%) patients failed to satisfy one of the features of HC. Thirteen patients (21%) did not show any evidence of cranial autonomic feature during the episodes of the exacerbations (HC-A). Another 19 patients (31%) did not show a complete response to indomethacin (HC-I). Epidemiological and clinical features of all three groups were compared. None of the differences were statistically significant. In review of the literature, we noted that cranial autonomic features, a sense of restlessness/agitation during exacerbations, and response to indomethacin (marked to complete) are the specific features of HC. However, these features may not all be present in all cases. Conclusion: Present diagnostic criteria are too restrictive. We suggest adding the site of pain in the criteria, as described for trigeminal autonomic cephalalgias. Cranial autonomic features, a sense of restlessness during exacerbations, and marked to complete response to indomethacin are three characteristics features of HC. We suggest that the presence of any two may be sufficient to diagnose HC.
Hydroxycloroquine-induced oxidative stress on sciatic nerve and muscle tissue of rats
Authors: Uzar E , Ozay R , Evliyaoglu O , Aktas A , Ulkay MB , Uyar ME , Ersoy A , Burakgazi AZ , Turkay C , Ilhan A 
Published: June 2012

The aim of this study was to investigate the role of hydroxychloroquine (HCQ)-induced oxidative stress on sciatic nerve and muscle tissues of rats. The oxidant/antioxidant parameters in the sciatic nerve and muscle tissues were analyzed, and stereological analysis of the sciatic nerve was performed. Levels of malondialdehyde and nitric oxide in the tissues were significantly higher in the HCQ group than in the control group ( p < 0.05). In addition, activities of superoxide dismutase and glutathione peroxidase were found to be significantly higher in the HCQ group than the control group ( p < 0.05). There were significant decreases in nerve fiber diameter and myelin sheet thickness in the HCQ group compared with the control group ( p < 0.05). These results revealed that HCQ might increase oxidative stress on sciatic nerve and muscle tissues of rats, which may correlate with axonal atrophy in sciatic nerves.
Altered expression of hepatic metabolic enzyme and apoptosis-related gene transcripts in human hepatocytes treated with trichloroethylene
Authors: Xu XY , Liu YF , Lu LW , Ke YB , Mao JY , Mao KL 
Published: June 2012

Trichloroethylene (TCE) is a common organic solvent that has been widely used in industrial applications. Hundred cases of allergic reactions occurred after the workers were occupationally exposed to TCE in China in the past decade, but the underlying effector mechanisms of TCE remain unclear. The purpose of the present study is to examine the alteration of hepatic metabolic enzyme gene and apoptosis-related gene messenger RNA (mRNA) expression in L02 human hepatocytes (L02 cells) after treatment with TCE. L02 cells were cultured either with various doses of TCE (0.25, 0.5, 1.0 and 2.0 mmol/L) for 24 h or with a single dose of TCE (1.0 mmol/L) for different time intervals, whereas samples treated with dimethyl sulfoxide served as control. Quantitative real-time polymerase chain reaction analysis was performed to detect the mRNA expression of hepatic metabolic enzyme genes ( CYP1A2, CYP3A4 and CYP2E1) and apoptosis-related genes ( BAX and BAD). It was found that the transcript levels of hepatic metabolic enzyme genes and apoptosis genes including BAX and BAD were significantly increased after TCE treatment at various doses for 24 h when compared with controls. Additionally, when the cells were treated with a single dose of TCE (1.0 mmol/L) for different periods of time (3, 6, 12 and 24 h), the mRNA expression of these genes also increased significantly compared with control ( p < 0.05 or p < 0.01). The conclusion of the study is that TCE could induce alteration of mRNA expression of hepatic metabolic enzyme genes and apoptosis genes, which might be implicated in the effector mechanisms of TCE cytotoxicity in vivo.
Primary thrombophilia in Mexico IX
Authors: Ruiz-Argüelles Guillermo J. , Garcés-Eisele Javier , Camacho-Alarcón Cecilia , Reyes-Nuñez Virginia , Moncada-González Benjamín , Valdés-Tapia Patricia , León-Montes Nancy , Ruiz-Delgado Guillermo J. 
Published: June 2012

Introduction: The sticky platelet syndrome (SPS) seems to be a common cause of thrombosis, although no molecular substrate to explain platelet hyperaggregability has been found. Objective: To analyze an association between the SPS phenotype and the platelet glycoprotein (GP) IIIa PLA1/A2 (human platelet antigen [HPA]-1a/b) gene polymorphism. Methods: Along an 18-month period, Mexican mestizo thrombophilic patients were prospectively accrued. The SPS phenotype was assessed by aggregometry, whereas a tetra-primer amplification refractory mutation system (ARMS) polymerase chain reaction analysis was used to detect the PLA1 and PLA2 alleles. Results: A total of 95 individuals with SPS and 127 healthy donors were studied; in 11 of the donors and 16 of the patients with SPS the A2 allele of the GP IIb/IIIA was found, yielding a weak and nonsignificant association (odds ratio 2.14, 95% CI 0.94-4.85). Conclusion: In Mexican mestizo patients, the platelet GP IIIa PLA1/A2 gene polymorphism does not lead to the SPS phenotype.
Trabzonite, Ca4[Si3O9(OH)]OH: crystal structure, revised formula, new occurrence and relation to killalaite
Authors: Armbruster T. , Lazic B. , Galuskina I. O. , Galuskin E. V. , Gnos E. , Marzec K. M. , Gazeev V. M. 
Published: July 2012

AbstractThe crystal structure of the rare skarn mineral trabzonite, Ca4[Si3O9(OH)]OH, from the type locality near Ikizdere, Turkey and from the Upper Chegem caldera, Northern Caucasus, Kabardino-Balkaria, Russia has been solved and refined using single-crystal X-ray data. This shows that the chemical formula should be modified from Ca4(Si3O10)˙2H2O, reported in the original trabzonite description, to an OH-bearing composition. The crystal structure, which contains Si3O10 trimers embedded in a framework of CaO6–8 polyhedra, has orthorhombic symmetry, space group Ama2, a = 20.6, b = 9.1, c = 10.3 Å. The orthorhombic A-centred cell is easily obtained by transformation from the original monoclinic cell of P21/m symmetry. The revised formula means that trabzonite and foshagite are polymorphs; foshagite has wollastonite-like silicate chains and in contrast to trabzonite it does not contain silanol groups. The structure and composition of killalaite from both localities was also studied. Single-crystal X-ray structure refinement of killalaite from the Northern Caucasus confirmed it to be non-stoichiometric with a composition between Ca6[Si2O6(OH)]2(OH)2 and Ca7[Si2O7]2(OH)2(Z = 2). Trabzonite, killalaite and dellaite form a series of modular structures which differ mainly in the degree of condensation of the SiO4 units.
Distinct and overlapping gene regulatory networks in BMP- and HDAC-controlled cell fate determination in the embryonic forebrain
Authors: Scholl Catharina , Weiβmüller Kathrin , Holenya Pavlo , Shaked-Rabi Maya , Tucker Kerry L , Wölfl Stefan 
Published: July 2012

Abstract

Background
Both bone morphogenetic proteins (BMPs) and histone deacetylases (HDACs) have previously been established to play a role in the development of the three major cell types of the central nervous system: neurons, astrocytes, and oligodendrocytes. We have previously established a connection between these two protein families, showing that HDACs suppress BMP-promoted astrogliogenesis in the embryonic striatum. Since HDACs act in the nucleus to effect changes in transcription, an unbiased analysis of their transcriptional targets could shed light on their downstream effects on BMP-signaling.

Results
Using neurospheres from the embryonic striatum as an in vitro system to analyze this phenomenon, we have performed microarray expression profiling on BMP2- and TSA-treated cultures, followed by validation of the findings with quantitative RT-PCR and protein analysis. In BMP-treated cultures we first observed an upregulation of genes involved in cell-cell communication and developmental processes such as members of BMP and canonical Wnt signaling pathways. In contrast, in TSA-treated cultures we first observed an upregulation of genes involved in chromatin modification and transcription. Interestingly, we could not record direct changes in the protein levels of canonical members of BMP2 signaling, but we did observe an upregulation of both the transcription factor STAT3 and its active isoform phospho-STAT3 at the protein level.

Conclusions
STAT3 and SMAD1/5/8 interact synergistically to promote astrogliogenesis, and thus we show for the first time that HDACs act to suppress BMP-promoted astrogliogenesis by suppression of the crucial partner STAT3.
Seeking consent to genetic and genomic research in a rural Ghanaian setting: A qualitative study of the MalariaGEN experience
Authors: Tindana Paulina , Bull Susan , Amenga-Etego Lucas , de Vries Jantina , Aborigo Raymond , Koram Kwadwo , Kwiatkowski Dominic , Parker Michael 
Published: July 2012

Abstract

Background
Seeking consent for genetic and genomic research can be challenging, particularly in populations with low literacy levels, and in emergency situations. All of these factors were relevant to the MalariaGEN study of genetic factors influencing immune responses to malaria in northern rural Ghana. This study sought to identify issues arising in practice during the enrolment of paediatric cases with severe malaria and matched healthy controls into the MalariaGEN study.

Methods
The study used a rapid assessment incorporating multiple qualitative methods including in depth interviews, focus group discussions and observations of consent processes. Differences between verbal information provided during community engagement processes, and consent processes during the enrolment of cases and controls were identified, as well as the factors influencing the tailoring of such information.

Results
MalariaGEN participants and field staff seeking consent were generally satisfied with their understanding of the project and were familiar with aspects of the study relating to malaria. Some genetic aspects of the study were also well understood. Participants and staff seeking consent were less aware of the methodologies employed during genomic research and their implications, such as the breadth of data generated and the potential for future secondary research.
Moreover, trust in and previous experience with the Navrongo Health Research Centre which was conducting the research influenced beliefs about the benefits of participating in the MalariaGEN study and subsequent decision-making about research participation.

Conclusions
It is important to recognise that some aspects of complex genomic research may be of less interest to and less well understood by research participants and that such gaps in understanding may not be entirely addressed by best practice in the design and conduct of consent processes. In such circumstances consideration needs to be given to additional protections for participants that may need to be implemented in such research, and how best to provide such protections.
Capacity building for research ethics committees with limited familiarity with genetic and genomic research, and appropriate engagement with communities to elicit opinions of the ethical issues arising and acceptability of downstream uses of genome wide association data are likely to be important.