bluuebunny/crossref_metadata_2025_split huggingface dataset:
New species and additional records in the lichen genus Malmidea from India
Authors: Adhikari Rakesh , Ngangom Roshinikumar , Ingle Komal K. , Joseph Siljo , Nayaka Sanjeeva 
Published: May 2024

AbstractA detailed examination of Malmidea specimens deposited in the herbarium LWG and freshly collected samples resulted in the description of 10 new species. Malmidea glabromarginata has a finely verrucose thallus and granifera-type whitish apothecial margins. Malmidea globosa is characterized by having a strongly verrucose thallus with almost spherical warts and piperis-type apothecial margins. Malmidea incrassatispora has a thalline excipulum and ascospores with end wall thickenings. Malmidea kalbii has a thalline excipulum, dark brown to black apothecial discs and ascospores mostly < 15 μm in length. In Malmidea lutea the medulla of the thallus and verrucae is white to cream-coloured, with beige-coloured apothecial discs. Malmidea palghatensis has a thalline excipulum and with medulla of verrucae pink-coloured. Malmidea rubra has an irregularly verrucose thallus, with the medulla of verrucae orange-red and whitish apothecial margins. Malmidea subindica has light to dark orange-brown apothecial discs, 2–4-spored asci, and broadly ellipsoid ascospores mostly exceeding 30 μm in length. Malmidea upretii has prominent and confluent verrucae with an orange-red medulla, and ascospores exceeding 25 μm in length. Malmidea verrucosa has a characteristic whitish grey, densely verrucose thallus, dark reddish brown apothecial discs and contains atranorin. Additionally, seven species, viz. Malmidea fenicis (Vain.) Kalb et al., M. leptoloma (Müll. Arg.) Kalb & Lücking, M. piae (Kalb) Kalb, M. piperina (Zahlbr.) Aptroot & Breuss, M. reunionis Kalb, M. sulphureosorediata Cáceres et al. and M. vinosa (Eschw.) Kalb et al., are reported as new distributional records for the Indian lichen biota. The world key of Malmidea by Breuss & Lücking (2015) has been updated with all the species discovered after 2015 by mentioning specific couplets.
Three new species of thelotremoid lichens (lichenized Ascomycota: Ostropales) with 15 new records of lichenized fungi from Thailand and a worldwide key to species of the genus Ampliotrema
Authors: Poengsungnoen Vasun , Nirongbut Phimpha , Buaruang Kawinnat , Boonpragob Kansri , Lumbsch H. Thorsten , Polyiam Wetchasart 
Published: May 2024

AbstractThree new species of thelotremoid lichens, Ampliotrema subglobosum Poengs. & Lumbsch, Ocellularia lichexanthonica Poengs. & Lumbsch and O. saxiprotocetrarica Poengs. & Lumbsch, are described and illustrated based on specimens from southern Thailand. Ampliotrema subglobosum is similar to A. globosum but differs by having larger ascospores with more septa. Ocellularia lichexanthonica differs from O. subdolichotata in ascomata diameter and by containing lichexanthone. Ocellularia saxiprotocetrarica is similar to O. gentingensis in ascospore length and the number of ascospore septa but has narrower ascospores and contains protocetraric acid. Fifteen species are reported for the first time for Thailand: Austrotrema bicinctulum (Nyl.) I. Medeiros et al., Baeomyces heteromorphus Nyl. ex C. Bab. & Mitt., Chapsa niveocarpa Mangold, Chiodecton sphaerale Ach., Erythrodecton malacum (Kremp.) G. Thor, Lecanora subjaponica L. Lü & H. Y. Wang, Leucodecton subcompunctum (Nyl.) Frisch, Myriotrema concretum (Fée) Hale, M. neoterebrans Frisch, Ocellularia khasiana (Patw. & Nagarkar) Kraichak et al., O. upretii S. Joshi et al., Pseudotopeliopsis scabiomarginata (Hale) Parnmen et al., Sulzbacheromyces sinensis (R. H. Petersen & M. Zang) Dong Liu & Li S. Wang, Thelotrema diplotrema Nyl., and T. isidiophorum (Kremp.) Zahlbr. Ampliotrema globosum (Hale) Poengs. & Lumbsch is proposed as a new combination. The genus Erythrodecton G. Thor is a new genus for the lichen flora of Thailand.
Vaccination induces broadly neutralizing antibody precursors to HIV gp41
Authors: Schiffner Torben , Phung Ivy , Ray Rashmi , Irimia Adriana , Tian Ming , Swanson Olivia , Lee Jeong Hyun , Lee Chang-Chun D. , Marina-Zárate Ester , Cho So Yeon , Huang Jiachen , Ozorowski Gabriel , Skog Patrick D. , Serra Andreia M. , Rantalainen Kimmo , Allen Joel D. , Baboo Sabyasachi , Rodriguez Oscar L. , Himansu Sunny , Zhou Jianfu , Hurtado Jonathan , Flynn Claudia T. , McKenney Katherine , Havenar-Daughton Colin , Saha Swati , Shields Kaitlyn , Schultze Steven , Smith Melissa L. , Liang Chi-Hui , Toy Laura , Pecetta Simone , Lin Ying-Cing , Willis Jordan R. , Sesterhenn Fabian , Kulp Daniel W. , Hu Xiaozhen , Cottrell Christopher A. , Zhou Xiaoya , Ruiz Jennifer , Wang Xuesong , Nair Usha , Kirsch Kathrin H. , Cheng Hwei-Ling , Davis Jillian , Kalyuzhniy Oleksandr , Liguori Alessia , Diedrich Jolene K. , Ngo Julia T. , Lewis Vanessa , Phelps Nicole , Tingle Ryan D. , Spencer Skye , Georgeson Erik , Adachi Yumiko , Kubitz Michael , Eskandarzadeh Saman , Elsliger Marc A. , Amara Rama R. , Landais Elise , Briney Bryan , Burton Dennis R. , Carnathan Diane G. , Silvestri Guido , Watson Corey T. , Yates John R. , Paulson James C. , Crispin Max , Grigoryan Gevorg , Ward Andrew B. , Sok Devin , Alt Frederick W. , Wilson Ian A. , Batista Facundo D. , Crotty Shane , Schief William R. 
Published: May 2024

AbstractA key barrier to the development of vaccines that induce broadly neutralizing antibodies (bnAbs) against human immunodeficiency virus (HIV) and other viruses of high antigenic diversity is the design of priming immunogens that induce rare bnAb-precursor B cells. The high neutralization breadth of the HIV bnAb 10E8 makes elicitation of 10E8-class bnAbs desirable; however, the recessed epitope within gp41 makes envelope trimers poor priming immunogens and requires that 10E8-class bnAbs possess a long heavy chain complementarity determining region 3 (HCDR3) with a specific binding motif. We developed germline-targeting epitope scaffolds with affinity for 10E8-class precursors and engineered nanoparticles for multivalent display. Scaffolds exhibited epitope structural mimicry and bound bnAb-precursor human naive B cells in ex vivo screens, protein nanoparticles induced bnAb-precursor responses in stringent mouse models and rhesus macaques, and mRNA-encoded nanoparticles triggered similar responses in mice. Thus, germline-targeting epitope scaffold nanoparticles can elicit rare bnAb-precursor B cells with predefined binding specificities and HCDR3 features.
Multimodal assessment improves neuroprognosis performance in clinically unresponsive critical-care patients with brain injury
Authors: Rohaut B. , Calligaris C. , Hermann B. , Perez P. , Faugeras F. , Raimondo F. , King J-.R. , Engemann D. , Marois C. , Le Guennec L. , Di Meglio L. , Sangaré A. , Munoz Musat E. , Valente M. , Ben Salah A. , Demertzi A. , Belloli L. , Manasova D. , Jodaitis L. , Habert M. O. , Lambrecq V. , Pyatigorskaya N. , Galanaud D. , Puybasset L. , Weiss N. , Demeret S. , Lejeune F. X. , Sitt J. D. , Naccache L. 
Published: May 2024

AbstractAccurately predicting functional outcomes for unresponsive patients with acute brain injury is a medical, scientific and ethical challenge. This prospective study assesses how a multimodal approach combining various numbers of behavioral, neuroimaging and electrophysiological markers affects the performance of outcome predictions. We analyzed data from 349 patients admitted to a tertiary neurointensive care unit between 2009 and 2021, categorizing prognoses as good, uncertain or poor, and compared these predictions with observed outcomes using the Glasgow Outcome Scale–Extended (GOS-E, levels ranging from 1 to 8, with higher levels indicating better outcomes). After excluding cases with life-sustaining therapy withdrawal to mitigate the self-fulfilling prophecy bias, our findings reveal that a good prognosis, compared with a poor or uncertain one, is associated with better one-year functional outcomes (common odds ratio (95% CI) for higher GOS-E: OR = 14.57 (5.70–40.32), P < 0.001; and 2.9 (1.56–5.45), P < 0.001, respectively). Moreover, increasing the number of assessment modalities decreased uncertainty (OR = 0.35 (0.21–0.59), P < 0.001) and improved prognostic accuracy (OR = 2.72 (1.18–6.47), P = 0.011). Our results underscore the value of multimodal assessment in refining neuroprognostic precision, thereby offering a robust foundation for clinical decision-making processes for acutely brain-injured patients. ClinicalTrials.gov registration: NCT04534777.
The gut microbiota in persistent post-operative pain following breast cancer surgery
Authors: Masaud Khaled , Collins James M. , Rubio Raul Cabrera , Corrigan Mark , Cotter Paul D. , O’Brien Niall , Bluett Ronan , Jimenez Clare Keaveney , O’Mahony Siobhain M. , Shorten George D. 
Published: May 2024

AbstractPersistent post-surgical pain (PPSP) is defined as pain which continues after a surgical operation in a significant form for at least three months (and is not related to pre-existing painful conditions). PPSP is a common, under-recognised, and important clinical problem which affects millions of patients worldwide. Preventative measures which are currently available include the selection of a minimally invasive surgical technique and an aggressive multimodal perioperative analgesic regimen. More recently, a role for the gut microbiota in pain modulation has become increasingly apparent. This study aims to investigate any relationship between the gut microbiota and PPSP. A prospective observational study of 68 female adult patients undergoing surgery for management of breast cancer was carried out. Stool samples from 45 of these patients were obtained to analyse the composition of the gut microbiota. Measures of pain and state-trait anxiety were also taken to investigate further dimensions in any relationship between the gut microbiota and PPSP. At 12 weeks postoperatively, 21 patients (51.2%) did not have any pain and 20 patients (48.8%) reported feeling pain that persisted at that time. Analysis of the gut microbiota revealed significantly lower alpha diversity (using three measures) in those patients reporting severe pain at the 60 min post-operative and the 12 weeks post-operative timepoints. A cluster of taxa represented by Bifidobacterium longum, and Faecalibacterium prausnitzii was closely associated with those individuals reporting no pain at 12 weeks postoperatively, while Megamonas hypermegale, Bacteroides pectinophilus, Ruminococcus bromii, and Roseburia hominis clustered relatively closely in the group of patients fulfilling the criteria for persistent post-operative pain. We report for the first time specific associations between the gut microbiota composition and the presence or absence of PPSP. This may provide further insights into mechanisms behind the role of the gut microbiota in the development of PPSP and could inform future treatment strategies.
Application in environmental art design practice based on a fuzzy evaluation system
Authors: Sang Yongliang 
Published: May 2024

AbstractEnvironmental art design (EAD) has recently encouraged creative thinking by investigating novel materials, technologies, and techniques for designing environmental art that advances sustainability. EAD faces challenges in integrating novel materials and technologies while promoting sustainability. Environmental art design is targeted at human living areas; here, adequate and excessive utilization of resources is minimized, and the social and natural environments are utilized aesthetically. Aesthetic excellence in environmental art design, along with growing technological accomplishments and cultural heritage, is concentrated on meeting the demands of human aesthetic pursuits in the new era, which lacks earlier techniques. Hence, an algorithm named environmental art design using fuzzy (EADF) to evaluate the environmental criteria for better decision-making is introduced. Initially, a fuzzy-based technique for order preference similar to the ideal solution (FTOPSIS), which considers multiple variables such as visual appeal, environmental impact, sustainability, and audience involvement in the community, was employed in the design process. Environmental art designers utilize fuzzy TOPSIS to assess works of art using several criteria. It seeks to make accurate decisions and accomplish desirable creative effects by considering ambiguity and subjectivity. The approach utilizes fuzzy variable entropy analysis to determine questionable attribute weightings and employs triangular fuzzy numbers to represent criteria and analyze preference values. Artworks are evaluated for deviation from ideal results using the Euclidean distance measure, enabling logical ranking evaluation and comparison. The EADF model outperforms the other models when considering different input factors. EADF excels in color (83.74), composition (82.37), emotion (85.61), contrast (97.52), clarity (98.16), harmony (95.49), and sensitivity (96.44) when evaluated in environmental art design, showcasing its usefulness. This work has implications for directing artists, designers, and decision-makers toward environmentally sustainable and artistically impactful art practices. Hence, the performance of this EADF model is validated using audience involvement, environmental impact, sustainability, and a visual appeal score.
Influence of linearly polarized light on the transverse relaxation of ground-state 133Cs atoms
Authors: Ding Zhichao , Yuan Jie 
Published: May 2024

AbstractIn order to obtain an understanding of the relationship between the optical absorption and the transverse relaxation, the influences of linearly polarized light respectively at 133Cs D1 and D2 lines on the transverse relaxation of ground-state 133Cs atoms are studied. Under different vapor temperatures, light intensities and light frequencies, transverse spin relaxation times are separately measured for 133Cs atoms in different hyperfine levels. For theoretically analyzing the measuring results, especially for an unusual trend that the transverse spin relaxation time rises with the increase of light intensity, photon absorption cross-sections of linearly polarized light by 133Cs atoms are simulated. The experimental results show that through influencing the optical absorption and spin-exchange collisions, the linearly polarized light plays a remarkable role in the transverse spin relaxation. The results obtained by this paper can provide a guide to find the optimal intensity and frequency of linearly polarized light in practical applications for decreasing the influences of linearly polarized light on the transverse relaxation.
Critical-edge based tabu search algorithm for solving large-scale multi-vehicle Chinese postman problem
Authors: Tang Jizhou , He Lili , Cao Yinghui , Bai Hongtao 
Published: May 2024

AbstractThe min–max multi-vehicle Chinese postman problem is an NP-hard problem, which is widely used in path planning problems based on road network graphs, such as urban road structure probing planning, urban road underground cavity detection planning, high-voltage line inspection planning, and so on. With the rapid increase in the number of nodes and connections of road network graph, the solution time and path equilibrium constraints pose new challenges to the problem solving. In this paper, we propose a critical-edge tabu search algorithm, CTA-kroutes, for solving the min–max multi-vehicle postman problem for large-scale road networks. First, the initial solution with balanced path lengths is obtained by segmenting the Eulerian paths; second, the critical edges are moved in the initial solution to construct the neighborhood solution, and the tabu search algorithm is used to find the optimal solution iteratively; and lastly, the solution optimization algorithm is used at the end of each iteration to de-duplicate and optimally reconstruct the current search result. Experiments show that the CTA-kroutes algorithm can effectively improve the equalization of multi-vehicle paths and its applicability to large-scale road networks.
Low to moderate dose 137Cs (γ) radiation promotes M2 type macrophage skewing and reduces atherosclerotic plaque CD68+ cell content in ApoE(−/−) mice
Authors: Rey N. , Ebrahimian T. , Gloaguen C. , Kereselidze D. , Christelle E. , Brizais C. , Bachelot F. , Riazi G. , Monceau V. , Demarquay C. , Zineddine I. Garali , Klokov D. , Lehoux S. , Ebrahimian Teni G. 
Published: May 2024

AbstractThe effects of low doses of ionizing radiation on atherosclerosis remain uncertain, particularly as regards the generation of pro- or anti-inflammatory responses, and the time scale at which such effects can occur following irradiation. To explore these phenomena, we exposed atheroprone ApoE(−/−) mice to a single dose of 0, 0.05, 0.5 or 1 Gy of 137Cs (γ) administered at a 10.35 mGy min−1 dose rate and evaluated short-term (1–10 days) and long-term consequences (100 days). Bone marrow-derived macrophages were derived from mice 1 day after exposure. Irradiation was associated with a significant skewing of M0 and M2 polarized macrophages towards the M2 phenotype, as demonstrated by an increased mRNA expression of Retnla, Arg1, and Chil3 in cells from mice exposed to 0.5 or 1 Gy compared with non-irradiated animals. Minimal effects were noted in M1 cells or M1 marker mRNA. Concurrently, we observed a reduced secretion of IL-1β but enhanced IL-10 release from M0 and M2 macrophages. Effects of irradiation on circulating monocytes were most marked at day 10 post-exposure, when the 1 Gy dose was associated with enhanced numbers of both Ly6CHigh and Ly6Low cells. By day 100, levels of circulating monocytes in irradiated and non-irradiated mice were equivalent, but anti-inflammatory Ly6CLow monocytes were significantly increased in the spleen of mice exposed to 0.05 or 1 Gy. Long term exposures did not affect atherosclerotic plaque size or lipid content, as determined by Oil red O staining, whatever the dose applied. Similarly, irradiation did not affect atherosclerotic plaque collagen or smooth muscle cell content. However, we found that lesion CD68+ cell content tended to decrease with rising doses of radioactivity exposure, culminating in a significant reduction of plaque macrophage content at 1 Gy. Taken together, our results show that short- and long-term exposures to low to moderate doses of ionizing radiation drive an anti-inflammatory response, skewing bone marrow-derived macrophages towards an IL-10-secreting M2 phenotype and decreasing plaque macrophage content. These results suggest a low-grade athero-protective effect of low and moderate doses of ionizing radiation.
Comparative study on the establishment efficacy of four types of animal models of rectovaginal fistula in rabbits
Authors: Zhang Miaomiao , Zhao Xuhe , Mao Jianqi , Shi Aihua , Lyu Xin , Lyu Yi , Yan Xiaopeng 
Published: May 2024

AbstractVarious surgical methods have so far been developed for treating rectovaginal fistula (RVF), each with its own advantages and disadvantages. The lack of standardized animal models of RVF is a major reason for the failure to establish a unified and effective surgical method for the treatment of RVF. This study aimed to explore the feasibility of an RVF animal model by magnetic compression and compare it with the traditional modeling method. Thirty-two female Japanese white rabbits were randomly divided into four groups: A, B, C, and D, based on how the rectovaginal septum was treated. The operation time, intraoperative blood loss, and model success rate of each group were determined. The experimental animals were euthanized 2 weeks after the operation. Their rectovaginal septum specimens were obtained. RVF was observed by the naked eye. The fistula size was measured. Histological changes of fistula were observed by hematoxylin and eosin and Masson staining. All rabbits completed the RVF model and survived 2 weeks after the operation. Groups A and B had no bleeding, while groups C and D had < 0.5 mL of bleeding. The magnet detached in 4–6 days in group A, while it remained in place for 2 weeks after surgery in group B. Only one group D rabbit had a plastic hose for 2 weeks after surgery. The RVFs of groups A and C healed by themselves. In group B, the fistula was well formed. In group D, fistula healing was observed in three animals and the diameter of the fistulas was only 2.82–4.64 mm in the other four animals. Groups B and D had a scar on the inner surface of fistulas. Our study shows that the magnetic compression technique based on the T-shaped magnet is a highly useful method to establishing a continuous and stable RVF model in rabbits.
Risk of second primary thyroid cancer in cancer survivors
Authors: Yuan Yewei , Sun Peng , Xiao Hualin , Li Lingfan , Li Junyan , Ai Xiang 
Published: May 2024

AbstractA risk factor for thyroid cancer (TC) may be a history of former cancer and cancer therapy. The precise risk of a second primary thyroid carcinoma has not yet been revealed. In this study, we evaluated standardized incidence ratios (SIRs) of second primary thyroid cancer (SPTC) with consideration of different conditions and further analyzed the clinicopathological characteristics and survival of these patients. The cohort was selected from the US Surveillance, Epidemiology, and End Results (SEER) Program between 1975 and 2019. The standardized incidence ratios, morbidity risk, clinicopathological features, and survival of second primary thyroid carcinoma were analyzed. Propensity score matching (PSM) was used to balance covariates. Kaplan–Meier method was performed to assess the survival outcomes. Overall, 7066 patients with SPTC and 83,113 patients with primary TC were identified. The SIR of TC in tumor patients was 1.51/10,000, statistically higher than the natural population (0.94/10,000, P < 0.05). The most significant tumors contributing to the increased SIRs of SPTC were acute lymphocytic leukemia (3.49/10,000), Hodgkin’s lymphoma-nodal (3.29/10,000), salivary gland cancer (3.23/10,000), and kidney and renal pelvis cancer (3.05/10,000). The incidence of TC increased significantly in tumor patients who received radiotherapy/chemotherapy before age 35. The age at diagnosis of the SPTC was much older than the primary TC (64.01 vs. 49.55 years, p < 0.001). The SPTC had a higher percentage of histological grades 3/4 (23.14% vs. 15.19%, p < 0.001). Survival analyses demonstrated a worse prognosis for the SPTC group compared to the primary TC group. But after PSM, the survival outcomes of the two groups tended to be equivalent (P = 0.584). The SIRs of TC are higher in tumor patients. The most significant factors contributing to the increased risk of SPTC were some specific former tumors and acceptance of radiotherapy/ chemotherapy before age 35. There was no significant difference in survival between SPTC and primary TC.