bluuebunny/crossref_metadata_2025_split huggingface dataset:
Craniofacial features resembling frontonasal dysplasia with a tubulonodular interhemispheric lipoma in the adult 3H1 tuft mouse
Authors: Fong Keith S. K. , Cooper Tiffiny Baring , Drumhiller Wallace C. , Somponpun S. Jack , Yang Shiming , Ernst Thomas , Chang Linda , Lozanoff Scott 
Published: January 2012

AbstractIntracranial lipomas are rare, but 45% of them occur along the midline cisterns between the hemispheres and are often associated with corpus callosum hypoplasia and craniofacial defects. They are difficult to detect as they are generally asymptomatic and visible by MRI or by postmortem examination. The exact cause of these interhemispheric lipomas is not known, but they arise from a developmental defect resulting in the maldifferentiation of mesenchymal cells into mesodermal derivatives that are not normally present. We have identified a new mouse mutant called tuft, exhibiting a forebrain, intracranial lipoma with midline craniofacial defects resembling frontonasal dysplasia (FND) that arose spontaneously in our wild‐type 3H1 colony. The tuft trait seems to be transmitted in recessive fashion, but approximately 80% less frequent than the expected Mendelian 25%, due to either incomplete penetrance or prenatal lethality. MRI and histologic analysis revealed that the intracranial lipoma occurred between the hemispheres and often protruded through the sagittal suture. We also observed a lesion at the lamina terminalis (LT) that may indicate improper closure of the anterior neuropore. We have mapped the tuft trait to within an 18 cM region on mouse chromosome 10 by microsatellite linkage analysis and identified several candidate genes involved with craniofacial development and cellular differentiation of adipose tissue. Tuft is the only known mouse model for midline craniofacial defects with an intracranial lipoma. Identifying the gene(s) and mutation(s) causing this early developmental defect will help us understand the pathogenesis of FND and related craniofacial disorders. © Birth Defects Research (Part A), 2012. © 2012 Wiley Periodicals, Inc.
Decentralized Control System Design under Uncertainty Using Mixed‐Integer Optimization
Authors: Paramasivan G. , Kienle A. 
Published: January 2012

AbstractDecentralized control system design comprises the selection of a suitable control structure and controller parameters. In this contribution, the optimal control structure and the optimal controller parameters are determined simultaneously using mixed‐integer dynamic optimization (MIDO) under uncertainty, to account for nonlinear process dynamics and various disturbance scenarios. Application of the sigma point method is proposed in order to approximate the expectation and the variance of a chosen performance index with a minimum number of points to solve the MIDO problem under uncertainty. The proposed methodology is demonstrated with a benchmark problem of an inferential control for a reactive distillation column. The results are compared with established heuristic design methods and with previous deterministic approaches.
Enhanced Fluorescence Detection of Metal Ions Using Light‐Harvesting Mesoporous Organosilica
Authors: Waki Minoru , Mizoshita Norihiro , Maegawa Yoshifumi , Hasegawa Takeru , Tani Takao , Shimada Toyoshi , Inagaki Shinji 
Published: January 2012

AbstractEnhanced fluorescence detection of metal ions was realized in a system consisting of a fluorescent 2,2′‐bipyridine (BPy) receptor and light‐harvesting periodic mesoporous organosilica (PMO). The fluorescent BPy receptor with two silyl groups was synthesized and covalently attached to the pore walls of biphenyl (Bp)‐bridged PMO powder. The fluorescence intensity from the BPy receptor was significantly enhanced by the light‐harvesting property of Bp‐PMO, that is, the energy funneling into the BPy receptor from a large number of Bp groups in the PMO framework which absorbed UV light effectively. The enhanced emission of the BPy receptor was quenched upon the addition of a low concentration of Cu2+ (0.15–1.2×10−6 M), resulting in the sensitive detection of Cu2+. Upon titration of Zn2+ (0.3–6.0×10−6 M), the fluorescence excitation spectrum was systematically changed with an isosbestic point at 375 nm through 1:1 complexation of BPy and Zn2+ similar to that observed in BPy‐based solutions, indicating almost complete preservation of the binding property of the BPy receptor despite covalent fixing on the solid surface. These results demonstrate that light‐harvesting PMOs have great potential as supporting materials for enhanced fluorescence chemosensors.
ChemInform Abstract: Synthesis of New Compound Gd5Ni19 with a Superlattice Structure and Hydrogen Absorption Properties.
Authors: Iwase Kenji , Mori Kazuhiro , Hoshikawa Akinori , Ishigaki Toru 
Published: January 2012

AbstractThe title compound is synthesized by arc‐melting of the elements under argon atmosphere followed by annealing between 1423 and 1573 K.
ChemInform Abstract: High‐Temperature, High‐Pressure Hydrothermal Synthesis and Characterization of an Open‐Framework Uranyl Silicate with Nine‐Ring Channels: Cs2UO2Si10O22.
Authors: Liu Hsin‐Kuan , Chang Wen‐Jung , Lii Kwang‐Hwa 
Published: January 2012

AbstractThe title compound is synthesized from a mixture of UO3, aqueous CsF, and SiO2 (gold ampule, 1600 bar, 580 °C, 2 d, 52% yield) and characterized by single crystal XRD, luminescence, and solid state NMR spectroscopy.
ChemInform Abstract: Optically Pure Bulky (Hetero)arylalkyl Carbinols via Kinetic Resolution.
Authors: Hu Bin , Meng Meng , Fossey John S. , Mo Weimin , Hu Xinquan , Deng Wei‐Ping 
Published: January 2012

AbstractA planar chiral nucleophilic ferrocene catalyst is employed in the kinetic resolution of bulky arylalkyl carbinols (I) to afford unreacted alcohols (R)‐I with extremely high enantiomeric excess in ideal conversions ranging from 50—56%.
ChemInform Abstract: Tandem Catalysis for the Synthesis of 2‐Alkylidene Cyclohexenones.
Authors: Pena Javier , Anton Ana B. , Moro Rosalina F. , Marcos Isidro S. , Garrido Narciso M. , Diez D. 
Published: January 2012

AbstractIn the absence of the 2nd catalyst DPL the reaction furnishes racemic products.
ChemInform Abstract: Efficient and Direct Nucleophilic Difluoromethylation of Carbonyl Compounds and Imines with Me3SiCF2H at Ambient or Low Temperature.
Authors: Zhao Yanchuan , Huang Weizhou , Zheng Ji , Hu Jinbo 
Published: January 2012

AbstractAromatic aldehydes, ketones and sulfinamides react effectively with silanes (I) or (V) to afford the corresponding difluoroalkylated products with high yields.
ChemInform Abstract: Iridium Phosphine Abnormal N‐Heterocyclic Carbene Complexes in Catalytic Hydrogen Transfer Reactions.
Authors: Gong Xue , Zhang Hong , Li Xingwei 
Published: January 2012

AbstractAn abnormal NHC complex ICP is applied as catalyst for the reduction of ketones and enones by transfer hydrogenation and for the dehydrative coupling between primary and secondary alcohols.
ChemInform Abstract: One‐Pot Preparation of N,N′‐Alkylidene Bisamide Derivatives Catalyzed by Silica Supported Magnesium Chloride (SiO2—MgCl2).
Authors: Shafiee Mohammad R. M. 
Published: January 2012

AbstractA highly efficient and simple procedure for the formation of the bisamide derivatives (III) via one‐pot three‐component condensation reaction of phenylacetylene/1‐hexyne, aldehydes and amides in the presence of catalytic amounts of silica supported magnesium chloride is reported.
ChemInform Abstract: Tandem Reactions of 1,2‐Allenic Ketones Leading to Substituted Benzenes and α,β‐Unsaturated Nitriles.
Authors: Zhang Xinying , Jia Xuefei , Fang Liangliang , Liu Nan , Wang Jianji , Fan Xuesen 
Published: January 2012

AbstractThe reaction of 1,2‐allenic ketones with cyanoacetate (II) proceeds via double Michael addition/intramolecular aldol reaction/decarboxylation to afford benzene products and tolerates a wide range of functional groups including halogens.
ChemInform Abstract: Palladium‐Catalyzed Cross‐Coupling of Sterically Demanding Boronic Acids with α‐Bromocarbonyl Compounds.
Authors: Zimmermann Bettina , Dzik Wojciech I. , Himmler Thomas , Goossen Lukas J. 
Published: January 2012

AbstractA new and efficient method to prepare α‐arylacetic acid derivatives and benzyl aryl ketones including sterically hindered ones is reported.
ChemInform Abstract: Palladium Nanoparticles in Carbon Thin Film‐Lined SBA‐15 Nanoreactors: Efficient Heterogeneous Catalysts for Suzuki—Miyaura Cross Coupling Reaction in Aqueous Media.
Authors: Zhi Jian , Song Depeng , Li Zhiwen , Lei Xia , Hu Aiguo 
Published: January 2012

AbstractNo leaching or aggregation of Pd nanoparticles is found in the nanoreactors after reusing them several times.
ChemInform Abstract: Rationally Designed Palladium Complexes on a Bulky N‐Heterocyclic Carbene‐Functionalized Organosilica: An Effficient Solid Catalyst for the Suzuki—Miyaura Coupling of Challenging Aryl Chlorides.
Authors: Li Guang , Yang Hengquan , Li Wei , Zhang Guoliang 
Published: January 2012

AbstractA wide range of aryl chlorides carrying even deactivating and sterically hindered groups can be successfully coupled under mild conditions.
ChemInform Abstract: Ph2P(O) Group for Protection of Terminal Acetylenes.
Authors: Yang Xin , Matsuo Daisuke , Suzuma Yoshinori , Fang Jing‐Kun , Xu Feng , Orita Akihiro , Otera Junzo , Kajiyama Shingo , Koumura Nagatoshi , Hara Kohjiro 
Published: January 2012

AbstractThe diphenylphosphoryl group is used to protect alkynes in Sonogashira coupling reactions.
ChemInform Abstract: Platinum‐Catalyzed Cycloisomerization of 1,4‐Enynes via 1,2‐Alkenyl Rearrangement.
Authors: Sato Takuma , Onuma Toshiki , Nakamura Itaru , Terada Masahiro 
Published: January 2012

AbstractThe reaction affords mostly mixtures of isomeric 1,2,3‐trisubstituted 1H‐indenes.
ChemInform Abstract: Addition of Arylboronic Acids to Arylpropargyl Alcohols en Route to Indenes and Quinolines.
Authors: Panteleev Jane , Huang Richard Y. , Lui Erica K. J. , Lautens Mark 
Published: January 2012

AbstractThe reaction of unprotected propargylic alcohols with arylboronic acids according to A) proceeds regio‐ and stereoselectively to afford trisubstituted allylic alcohols [cf.
ChemInform Abstract: A Sulfone‐Based Strategy for the Preparation of 2,4‐Disubstituted Furan Derivatives.
Authors: Murphree S. Shaun , et al. et al. 
Published: January 2012

AbstractBasic treatment of 2,4‐diones with the sulfone (II) allows convenient access to 2,4‐disubstituted furans like (III), accompanied by lower amounts of analogue (IV).
ChemInform Abstract: Enantioselective Pictet—Spengler Reactions of Isatins for the Synthesis of Spiroindolones.
Authors: Badillo Joseph J. , Silva‐Garcia Abel , Shupe Benjamin H. , Fettinger James C. , Franz Annaliese K. 
Published: January 2012

AbstractAmong various BINOL‐derived phosphoric acids, derivatives (Ia) and (Ib) are found to be the most efficient ones.
ChemInform Abstract: Efficient Synthesis of Polysubstituted Isochromanones via a Novel Photochemical Rearrangement.
Authors: Xia Wujiong , Shao Yutian , Gui Weijun , Yang Chao 
Published: January 2012

AbstractIrradiation of 2‐formyl phenylalkeno derivatives (I) and (III) with UV light affords polysubstituted isochromanones (II) and (IV), respectively, via a novel photochemical rearrangement.
ChemInform Abstract: Direct Sequential C3 nd C1 Arylation Reaction of Imidazo[1,5‐a]pyridine Catalyzed by a 1,10‐Phenanthroline—Palladium Complex.
Authors: Yamamguchi Eiji , Shibahara Fumitoshi , Murai Toshiaki 
Published: January 2012

AbstractReaction of imidazopyridine (I) with aryl iodides (II) occurs selectively at the 3‐position to afford the C‐3‐arylated products (III) exclusively.
ChemInform Abstract: One‐Pot Synthesis of Novel Photochromic Oxazine Compounds.
Authors: Zhao Weili , Carreira Erick M. 
Published: January 2012

AbstractThe novel 2,2‐disubstituted title compounds are prepared in a one‐pot manner from 9,10‐phenanthrenequinone and acrylic acid derivatives proceeding as a cascade of 5 reactions transformation.
ChemInform Abstract: Palladium‐Catalyzed Reaction of 2‐Alkynylhalobenzene with 2‐Alkynylbenzamide: An Efficient Approach to Indeno[1,2‐c]azepin‐3(2H)‐ones.
Authors: Luo Yong , Wu Jie 
Published: January 2012

AbstractTitle compounds (III) which incorporate both indene and unsaturated seven‐membered ring lactam skeletons are obtained in good to high yields.
ChemInform Abstract: Conjugation of Substituted Ferrocenyl to Thiadiazine as Apoptosis‐Inducing Agents Targeting the Bax/Bcl‐2 Pathway.
Authors: Miao Ruidong , Wei Juan , Lv Minghua , Cai Yan , Du Yuping , Hui Xinping , Wang Qin 
Published: January 2012

AbstractThe induction of apoptosis in human fibrosarcoma cells (HT1080) after treatment with newly synthesized ferrocenyl‐substituted heterocycles (III) is studied.
ChemInform Abstract: Cesium Ion Exchange on Synthetic Birnessite (Na0.35MnO2·0.6H2O).
Authors: Chitrakar Ramesh , Makita Yoji , Sonoda Akinari 
Published: January 2012

AbstractPoorly crystalline Na0.35MnO2·0.6H2O exhibits ion‐exchange properties with Cs+ with increasing Kd values of Cs+ with increasing solution pH.
CFD Simulation of Wet Scrubbers Part 1. Principles and Implementation into Commercial CFD Software
Authors: Pieloth Damian , Kohnen Boris , Schaldach Gerhard , Walzel Peter 
Published: January 2012

AbstractDie Auslegung und Optimierung von Nasswäschern ausschließlich anhand experimenteller Daten ist aufwendig. CFD‐Werkzeuge zur Simulation von Nasswäschern können Experimente begleiten, um die Abscheideleistung der Apparate zu steigern und den Entwicklungsaufwand zu reduzieren. Es wird die Implementierung eines Modells zur Staubabscheidung bei Nasswäschern in der Simulationsumgebung ANSYS CFX vorgestellt. Basis der Implementierung ist die modellhafte Beschreibung der Reinigungswirkung von Einzeltropfen in einer staubbeladenen Gasatmosphäre. Die berechneten spezifischen Reinigungsvolumina von Tropfen an einfachen Modellgeometrien zeigen eine gute Übereinstimmung mit Literaturwerten.
The dissolution phenomenon of lysozyme crystals
Authors: Müller C. , Ulrich J. 
Published: January 2012

AbstractDissolution studies on lysozyme crystals were carried out since the observed dissolution pattern look different from non‐protein dissolved crystals. The Tetragonal, High Temperature and Low Temperature Orthorhombic morphologies, crystallized using sodium chloride, were chosen and the influence of different pH, salt and protein concentration on their dissolution was investigated. An increase in pH and/or salt concentration can modify the dissolution behaviour. The pattern of the crystals during the dissolution process will, therefore, develop differently. Frequently a skeleton like crystal pattern followed by a falling apart of the crystals is observed. The multi‐component character of the lysozyme crystal (protein, water, buffer, salt) as well as “solvatomorphism” gives first insights in the phenomena happening in the dissolution process. (© 2012 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
What can reasonably be expected from a truth commission?: A Togolese view
Authors: Kpanake Lonzozou , Mullet Etienne 
Published: January 2012

AbstractA survey examining the personal views of a sample of 579 ordinary citizens living in Togo on the possible objectives, functions, powers, and composition of truth commissions was conducted. These citizens were sensitized to the idea of the creation of a truth commission in their country under the auspices of the United Nations. Some clear priorities were promoting reconciliation, strengthening the respect for human rights, acquiring knowledge about past atrocities, and restoring the dignity of victims. They did not expect truth commissions to have for their objectives the punishment of the perpetrators or the implementation of social and economic reforms.
Learning through deepening conversations: A key strategy of insight mediation
Authors: Picard Cheryl , Jull Marnie 
Published: January 2012

AbstractThis article discusses the theory and practice of the insight approach to mediation; an approach that applies Lonergan's philosophy of cognition to the field of conflict resolution. The authors focus on a specific type of learning conversation, known as deepening, that is important in the practice of insight mediation. To help us understand deepening conversations, they begin with an overview of the theoretical foundations from Lonergan on which the practice of deepening is based and then go on to describe key aspects of insight mediation. In the latter part of the article, and to illustrate the application of the theory to the practice of mediation, they take us through a simulated dialogue that involves a conflict between a father and daughter over the daughter's pending marriage.
Between Western theory and local practice: Cultural impediments to truth‐telling in Sierra Leone
Authors: Millar Gearoid 
Published: January 2012

AbstractAlthough truth commissions are thought to provide healing and justice in postwar situations, some scholars worry that such mechanisms emerge from Western theories that may be inapplicable in many cultural settings. Based on an ethnographic study of local experiences of the Truth and Reconciliation Commission for Sierra Leone, this article describes how local cultural dynamics determine whether truth‐telling is experienced as predicted by peacebuilding theory. This article argues that the variability of such dynamics, which create unique local conceptual constructs and norms, often militates against the application of truth‐telling processes, and that this was clearly the case in Sierra Leone.
Dynamic distribution of claudin proteins in pancreatic epithelia undergoing morphogenesis or neoplastic transformation
Authors: Westmoreland Joby J. , Drosos Yiannis , Kelly Jacqueline , Ye Jianming , Means Anna L. , Washington M. Kay , Sosa‐Pineda Beatriz 
Published: January 2012

AbstractBackground: The assembly of distinct proteins into tight junctions results in the formation of a continuous barrier that regulates the paracellular flux of water, ions, and small molecules across epithelia. The claudin protein family encompasses numerous major structural components of tight junctions. These proteins specify the permeability characteristics of tight junctions and consequently, some of the physiological properties of epithelia. Furthermore, defective claudin expression has been found to correlate with some diseases, tumor progression, and defective morphogenesis. Investigating the pattern of claudin expression during embryogenesis or in certain pathological conditions is necessary to begin disclosing the role of these proteins in health and disease. Results: This study analyzed the expression of several claudins during mouse pancreas organogenesis and in pancreatic intraepithelial neoplasias of mouse and human origin. Conclusions: Our results underscored a distinctive, dynamic distribution of certain claudins in both the developing pancreas and the pancreatic epithelium undergoing neoplastic transformation. Developmental Dynamics 241:583–594, 2012. © 2012 Wiley Periodicals Inc.
Developmental expression ofDrosophilaWiskott‐Aldrich Syndrome family proteins
Authors: Rodriguez‐Mesa Evelyn , Abreu‐Blanco Maria Teresa , Rosales‐Nieves Alicia E. , Parkhurst Susan M. 
Published: January 2012

AbstractBackground: Wiskott‐Aldrich Syndrome (WASP) family proteins participate in many cellular processes involving rearrangements of the actin cytoskeleton. To the date, four WASP subfamily members have been described inDrosophila:Wash, WASp, SCAR, and Whamy. Wash, WASp, and SCAR are essential during earlyDrosophiladevelopment where they function in orchestrating cytoplasmic events including membrane‐cytoskeleton interactions. A mutant for Whamy has not yet been reported.Results: We generated monoclonal antibodies that are specific toDrosophilaWash, WASp, SCAR, and Whamy, and use these to describe their spatial and temporal localization patterns. Consistent with the importance of WASP family proteins in flies, we find that Wash, WASp, SCAR, and Whamy are dynamically expressed throughout oogenesis and embryogenesis. For example, we find that Wash accumulates at the oocyte cortex. WASp is highly expressed in the PNS, while SCAR is the most abundantly expressed in the CNS. Whamy exhibits an asymmetric subcellular localization that overlaps with mitochondria and is highly expressed in muscle.Conclusions: All four WASP family members show specific expression patterns, some of which reflect their previously known roles and others revealing new potential functions. The monoclonal antibodies developed offer valuable new tools to investigate how WASP family proteins regulate actin cytoskeleton dynamics. Developmental Dynamics 241:608–626, 2012. © 2012 Wiley Periodicals, Inc.
New Bisaqua Picolinate‐Based Gadolinium Complexes as MRI Contrast Agents with Substantial High‐Field Relaxivities
Authors: Nonat Aline M. , Gateau Christelle , Fries Pascal H. , Helm Lothar , Mazzanti Marinella 
Published: January 2012

AbstractTwo new tripodal heptadentate ligands, H4dpaba (N,N′‐bis[(6‐carboxypyridin‐2‐yl)methyl]aspartic acid) and H3mpatcn(1,4‐bis(methoxycarbonyl)‐7‐[(6‐carboxypyridin‐2‐yl)methyl]‐1,4,7‐triazacyclononane), which bear one or two picolinate pendant arms, have been synthesised. Their lanthanide complexes have been characterised by NMR and fluorescence spectroscopy and potentiometry. Both ligands gave rise to water soluble 1:1 complexes with an increased thermodynamic stability (pGddpaba = 13.3, pGdmpatcn = 11.8, with pGdL = –log [Gd]free at pH 7.4, [Gd]total = 1 μM and [L]total = 10 μM) with respect to the analogous bisaqua complex [Gd(tpaa)(H2O)2] [H3tpaa = α,α′,α″‐nitrilotri(6‐methyl‐2‐pyridinecarboxylic acid), pGdtpaa = 11.2). The two inner‐sphere water molecules confer sizeable relaxivities (r1) to the complexes at high field at physiological pH: r1 = 8.90 and r1 = 7.35 mM–1 s–1 have been measured in HOD at 200 MHz for [Gd(dpaba)(HOD)2]– and [Gd(mpatcn)(HOD)2], respectively. Their relaxometric properties have been investigated by NMRD (Nuclear Magnetic Relaxation Dispersion) and 17O NMR spectroscopy. The formation of ternary complexes with physiological anions, such as acetate, hydrogen carbonate, hydrogen phosphate and citrate, has been monitored by 1H NMR spectroscopy at 200 MHz and pH 7.4. The addition of a large excess (0.6 M) of acetate, hydrogen phosphate and citrate led to the formation monoaqua ternary complexes. Even under these conditions, the average relaxivity remains higher or similar than most currently used contrast agents. Only hydrogen carbonate interacts strongly with the complexes and coordinates in a bidentate mode by displacing both water molecules to induce a twofold decrease in the relaxivity. Both complexes interact with serum albumin to form a macromolecular adduct with increased relaxivity. In particular, a twofold increase of relaxivity has been measured for [Gd(dpaba)(H2O)2]– in bovine serum, which suggests that anion binding does not significantly affect the relaxivity under these conditions.