bluuebunny/crossref_metadata_2025_split huggingface dataset:
Role of thioredoxin reductase 1 and thioredoxin interacting protein in prognosis of breast cancer
Authors: Cadenas Cristina , Franckenstein Dennis , Schmidt Marcus , Gehrmann Mathias , Hermes Matthias , Geppert Bettina , Schormann Wiebke , Maccoux Lindsey J , Schug Markus , Schumann Anika , Wilhelm Christian , Freis Evgenia , Ickstadt Katja , Rahnenführer Jörg , Baumbach Jörg I , Sickmann Albert , Hengstler Jan G 
Published: June 2010

Abstract
Introduction
The purpose of this work was to study the prognostic influence in breast cancer of thioredoxin reductase 1 (TXNRD1) and thioredoxin interacting protein (TXNIP), key players in oxidative stress control that are currently evaluated as possible therapeutic targets.

Methods
Analysis of the association of TXNRD1 and TXNIP RNA expression with the metastasis-free interval (MFI) was performed in 788 patients with node-negative breast cancer, consisting of three individual cohorts (Mainz, Rotterdam and Transbig). Correlation with metagenes and conventional clinical parameters (age, pT stage, grading, hormone and ERBB2 status) was explored. MCF-7 cells with a doxycycline-inducible expression of an oncogenic ERBB2 were used to investigate the influence of ERBB2 on TXNRD1 and TXNIP transcription.

Results
TXNRD1 was associated with worse MFI in the combined cohort (hazard ratio = 1.955; P < 0.001) as well as in all three individual cohorts. In contrast, TXNIP was associated with better prognosis (hazard ratio = 0.642; P < 0.001) and similar results were obtained in all three subcohorts. Interestingly, patients with ERBB2-status-positive tumors expressed higher levels of TXNRD1. Induction of ERBB2 in MCF-7 cells caused not only an immediate increase in TXNRD1 but also a strong decrease in TXNIP. A subsequent upregulation of TXNIP as cells undergo senescence was accompanied by a strong increase in levels of reactive oxygen species.

Conclusions
TXNRD1 and TXNIP are associated with prognosis in breast cancer, and ERBB2 seems to be one of the factors shifting balances of both factors of the redox control system in a prognostic unfavorable manner.
Surviving meningococcal septic shock in childhood: long-term overall outcome and the effect on health-related quality of life
Authors: Buysse Corinne MP , Vermunt Lindy CAC , Raat Hein , Hazelzet Jan A , Hop Wim CJ , Utens Elisabeth MWJ , Joosten Koen FM 
Published: June 2010

Abstract
Introduction
The purpose of this study was to evaluate associations between long-term physical and psychological outcome variables in patients who survived meningococcal septic shock (MSS) in childhood.

Methods
The study population was made up of all MSS patients requiring intensive care treatment between 1988 and 2001.

Results
A total of 120 patients visited the follow-up clinic (age at paediatric intensive care unit (PICU) admission 3.1 years; follow-up interval 9.8 years; age at follow-up 14.5 years (all medians)). Four major outcomes were considered: 1) major physical sequelae (defined as major scars and/or orthopaedic sequelae) (29/120), 2) mild neurological impairments (39/120), 3) problem behaviour (defined as a total score above the 90th percentile of the reference groups on questionnaires to screen for psychopathology) (16/114) and 4) total intelligence quotient < 85 (18/115). No differences were found between patients with major physical sequelae and patients without major physical sequelae as to the presence of problem behaviour or total IQ < 85. Also, no differences were found between patients with mild neurological impairments and patients without as to the presence of problem behaviour or total IQ < 85. Finally, no differences were found between patients with major physical sequelae and patients without as to the presence of mild neurological sequelae. Less favourable scores on behavioural and emotional problems were significantly associated with poorer health-related quality of life (HR-QoL). HR-QoL scores were to a lesser amount predicted by severity of illness at time of PICU admission or by adverse physical outcome.

Conclusions
Long-term adverse physical and psychological outcomes in survivors of MSS did not seem to be associated. Poorer HR-QoL was mainly predicted by problem behaviour.
The Densities of Modernism
Authors: Harney Elizabeth 
Published: June 2010

This essay looks at the career of pioneering Senegalese painter Iba N'Diaye and his relation to now well-established narratives of modernism in Senegal. Typical accounts of the mid-twentieth century equate the modern with the cultural patronage, Négritude writings, and state-sponsored visual arts movement that flourished under the first president of Senegal, Léopold Sédar Senghor. N'Diaye, as one of the first instructors at an art academy founded at Senghor's request, is often featured in the beginnings of this narrative, only to be marginalized when he chooses to relocate permanently to France and pursue alternative aesthetic horizons. As a result, the subtleties of his long career, the means through which his practices “belong to the modern,” and the cartographies and densities of a complex, cosmopolitan artistic life are lost in either overdetermined histories of African modernism or narrow accounts of European art history.
This essay is not concerned with securing a place for him within the mainstream history of modernism but rather investigating how models of “alternative modernities” might enable us to foreground the dialogical attitudes and practices that characterized often overlapping, interdependent, and contingent experiences of modernity and expressions of modernism. How do re-evaluations of the spatio-temporal parameters of the modern enable us to shift accounts of the Senegalese story (and readings of N'Diaye's oeuvre)? Does N'Diaye's career enable us to challenge increasingly standardized narratives of modernism in many parts of Africa that link it primarily with reverse discourses, resistance narratives, and political independence to suggest more fluid approaches to modernist subjectivity and attention to the varied “tenses” for the modern?
Exceeding Realism: Utopian Modern Art on the Nile and Abdel Hadi Al-Gazzar's Surrealistic Drawings
Authors: Shalem Avinoam 
Published: June 2010

From a sociocultural point of view, the term modern and its implications have formed, shaped, and even dictated the collective identity of the twentieth century. Therefore, questions relating to the birth of this term, its assessment, its manipulative methods, and especially its mechanisms of use, appliance, and adaptation must be critically addressed. The discourse of modernism within the postcolonial context in Asia and Africa seems to be unavoidable.
This essay discusses a particular moment in the history of Egypt, in which a modern supplement, or rather injection, was slipped into the blood of the Egyptian national identity. Thus, this essay deals with modernity in translation in the postcolonial zone and contributes to the effort to highlight the artistic activity in the Muslim world in the twentieth century—a century that has been mainly defined as Western and usually excludes any non-European and non-Western components from its modern discourse. In this article, several drawings and paintings of the modern Egyptian artist Abdel Hadi Al-Gazzar are discussed. The core of the discussion, however, centers on four of al-Gazzar's surrealist drawings that also include surrealist poems, written either by Al-Gazzar or by the Alexandrian poet Ahmad Mursi. These works of art clearly adopt the surrealist aesthetic language, both visual and verbal. The drawings illustrate a particular zeitgeist in the Egyptian artistic milieu and mirror the individual and genuine artistic response of Al-Gazzar to the utopian and almost mythical status given to surrealism in Egypt in the first half of the twentieth century. In addition, his works will be dealt with here as a reflection of the changing social and political context in Egypt at the end of the 1940s and during the 1950s.
Antenatal Consent in the SUPPORT Trial: Challenges, Costs, and Representative Enrollment
Authors: Rich Wade D. , Auten Kathy J. , Gantz Marie G. , Hale Ellen C. , Hensman Angelita M. , Newman Nancy S. , Finer Neil N. ,   for the National Institute of Child Health and Human Development Neonatal Research Network
Published: June 2010

OBJECTIVES:
The purposes of this study were to quantify the time and effort involved in obtaining prenatal consent for the Neonatal Research Network Surfactant Positive Airway Pressure and Pulse Oximetry Randomized Trial (SUPPORT) and to determine whether the enrolled infants were representative of the eligible population.

METHODS:
Eligible subjects were likely to deliver in the SUPPORT gestational age window (24–2767 weeks). Data included who approached the subjects for consent, how often they approached, the duration of each contact, whether consent was obtained, and whether subjects were enrolled in the trial. Eligible, nonenrolled infants entered into the Neonatal Research Network Generic Database throughout the period of SUPPORT enrollment were compared with enrolled infants.

RESULTS:
A total of 2826 women were identified at 18 sites, 2228 were approached for consent, and 1219 (54.7%) agreed. For 76.9% of those approached, &lt;3 visits (mean: 2.0 ± 1.2 visits) were required to complete the consent process. Of the 659 infants with consent who were delivered within the study window, 611 were enrolled. Mothers who received a neonatal consultation were more likely to give consent (P &lt; .001). The proportion of infants not exposed to steroids was significantly greater in the nonapproached group than in the approached group (20.0% vs 3.4%; P &lt; .0001).

CONCLUSION:
In a trial that involved preterm infants and required prenatal consent, &gt;5 women were identified as being likely to deliver in the SUPPORT gestational age window for each 1 who delivered an enrolled infant.
Acenocumarol-túladagolás okozta rectus abdominis bevérzések
Authors: Antal András , Kovács Zoltán , Varga József , Horváth László 
Published: June 2010

Absztrakt
A betegek tartós anticoagulans kezelésére gyakran választjuk az acenocumarolt. A gyógyszer túladagolása esetén a szervezet különböző helyein bevérzés keletkezhet. Három betegünknél különleges helyen, a rectus abdominis területén figyeltük meg suffusiók kialakulását. A jelenség diagnosztikus nehézséget okozhat, mivel a panaszok kezdetekor a hasfal bőrén elszíneződés nem látszik. A kórok megállapítását az anamnaesisben szereplő tartós véralvadásgátló-szedés segíti. A tapintáskor észlelt nyomásérzékeny hasfali rezisztencia a gyanút fokozza. A magas INR a haemorrhagiás szövődmény lehetőségét támogatja. Egyszerű esetben a diagnózis az anamnaesis, a tapintás, az INR és az ultrahang alapján felállítható. A bonyolultabb esetek tisztázásában a CT segíthet, de egyik betegünknél csak laparoscopiával jutottunk pontos diagnózishoz. A csökkent plazma-prothrombinszintet K-vitamin adásával minden esetben normalizálni tudtuk.
Acut hasi katasztrófát okozó, kizáródott, traumás eredetű rekeszsérv több évvel a balesetet követően
Authors: Pataki István , Horzov Myroslav , Chanis William 
Published: June 2010

Absztrakt
A balesetből kifolyólag keletkezett rekeszsérvet szövődmények esetén az életet veszélyeztető állapotok közé soroljuk. Főleg tompa hasi vagy mellkasi erőbehatások hozhatják létre, de előfordulnak nyílt sérülések esetében is. Békeidőben elsősorban közlekedési balesetek következményei. A bemutatott 59 éves férfibetegünk tipikus esete az acutan fel nem ismert és 16 év elteltével hasi katasztrófát okozó, kizáródott trauma eredetű rekeszsérvnek. A beteget ezen időszak alatt mellüregi izzadmány és COPD miatt kezelték.
Systematics of Allomedeia, a New Genus of Afrotropical Chloropidae (Diptera)
Authors: Mlynarek Julia J , Wheeler Terry A 
Published: June 2010

Abstract
Allomedeia new genus is described for five new species of oscinelline Chloropidae from the Afrotropical region. The following species are described; Allomedeia prolata new species (Kenya, Uganda); Allomedeia pulva new species (South Africa); Allomedeia stuckenbergi new species (South Africa); Allomedeia xanthotes new species (South Africa, type species of genus); and Allomedeia xuthomaina new species (Nigeria). Three additional species from South Africa and Nigeria represented only by females or damaged specimens are not formally described but are included in a key to species. Allomedeia belongs to the tribe Elachipterini, in a clade that also includes the Old World tropical genera Disciphus Becker, Alombus Becker, Sepsidoscinis Hendel, and Anatrichus Loew.
Molecular Cloning and Expression Pattern of a Lysophospholipase Gene from Antheraea pernyi (Lepidoptera: Saturniidae)
Authors: Liu Yan-Qun , Li Yu-Ping , Wu Song , Xia Run-Xi , Shi Sheng-Lin , Qin Li , Lu Cheng , Xiang Zhong-Huai 
Published: June 2010

Abstract
Lysophospholipase (LysoPLA) is one of the most important deacylating phospholipases. The LysoPLA gene from Antheraea pernyi (Guérin-Méneville) (Lepidoptera: Saturniidae) (ApLysoPLA), a well-known wild silkmoth, was isolated and characterized. The isolated ApLysoPLA cDNA sequence was 1151 bp, with an open reading frame of 663 bp encoding a polypeptide of 220 amino acids. The deduced ApLysoPLA protein sequence has 89 and 82% identity with Heliconius reato (L.) LysoPLA and Bombyx mori L. LysoPLA, respectively; however, it shows 66, 62, 50, and 47% identity with Tribolium castaneum (Herbst) LysoPLA, Drosophila melanogaster (Meigen) LysoPLA, Homo sapiens LysoPLA I, and Mus musculus LysoPLA I, respectively. Phylogenetic analysis indicated that lepidopteran LysoPLAs, including ApLysoPLA, might be a new member of the LysoPLA family. Semiquantitative reverse transcription-polymerase chain reaction analysis showed that the ApLysoPLA gene was transcribed during four developmental stages (egg, larva, pupa, and adult) and that it was present in all tissues tested (blood, midgut, silk glands, Malpighian tubules, spermaries, ovaries, brain, muscle, fat body, and body wall), with the most abundance in Malpighian tubules. Consequently, we refer that ApLysoPLA plays an important role in the development of A. pernyi.
Comparison of Fecundity and Body Size of Mexican and Argentinian Populations of Dalbulus maidis (Hemiptera: Cicadellidae)
Authors: Moya-Raygoza Gustavo , Garcia-Medina Cecilia 
Published: June 2010

Abstract
The corn leafhopper, Dalbulus maidis (Delong & Wolcott) (Hemiptera: Cicadellidae), is the most important vector of maize, Zea mays L., pathogens throughout the Americas. This species originated in central Mexico, and the farthest southern latitude of the corn leafhopper' range is in Argentina. A comparison of reproductive and phenotypic traits between Argentinian and Mexican (native) populations can aid in understanding the adaptation of Argentinian populations of the same species. In this study, we compare the fecundity and body size (wing length and head width) of central Mexican D. maidis populations from low (&lt;1,000-m) and high (&gt;1,000-m) elevations with Argentinian D. maidis populations from low (&lt;1,000 m) and high (&gt;1,000 m) elevations. Argentinian populations from high elevations show higher fecundity than Mexican high elevation populations. Furthermore, Argentinian females from high elevations are larger in body size than Argentinian females from low elevations and Mexican females from low and high elevations.
Morphological Characterization and Distribution of Antennal Sensilla of Six Fruit Flies (Diptera: Tephritidae)
Authors: Hu Fei , Zhang Guo-Na , Jia Fu-Xian , Dou Wei , Wang Jin-Jun 
Published: June 2010

Abstract
Fruit flies (Diptera: Tephritidae) are important pests of many fruits and vegetables. In this study, the external morphology, types, and distribution of antennal sensilla in both male and female adults of the six fruit fly species, including Bactrocera tau (Walker), Bactrocera dorsalis (Hendel), Bactrocera cucurbitae (Coquillett), Bactrocera minax (Enderlein), Bactrocera diaphora (Hendel), and Bactrocera scutellata (Hendel), were observed by using scanning electron microscopy. The antennae of the six fruit fly species consist of a basal scape, pedicel, and an elongated flagellum. Arising from the proximal dorsal ridge of flagellum there is an arista consisting of two short basal segments and a long thin distal segment. Six distinct morphological types of sensilla are recorded in both sexes, including microtrichial sensilla, sensilla chaetica, sensilla trichoid, sensilla basiconica, short type of sensilla basiconica, and sensilla coeloconica. The abundance and distribution of these six sensilla types on the antennae of both sexes are recorded. In addition, the possible functions of the above-mentioned sensilla types are discussed in light of previously published literature. The functions include the mechanoreception of microtrichial sensilla, sensilla chaetica, and sensilla trichoid; olfactory functions of sensilla basiconic, and sensilla coeloconica; and thermoreception of the short type of sensilla basiconica. Future functional antennal morphology and electrophysiological studies are needed to confirm these proposed functions.
Habitat and Grazing Influence on Terrestrial Ants in Subtropical Grasslands and Savannas of Argentina
Authors: Calcaterra Luis A , Cabrera Sonia M , Cuezzo Fabiana , Peréz Ignacio Jiménez , Briano Juan A 
Published: June 2010

AbstractThe maintenance of species diversity in modified and natural habitats is a central focus of conservation biology. The Iberá Nature Reserve (INR) protects highly diverse ecosystems in northeastern Argentina, including one of the largest freshwater wetlands in South America. Livestock grazing is one of the major disturbances to these ecosystems; however, its effect on ant diversity is poorly known. The objective of this work was to study the effect of savanna versus grassland and grazing on the structure and composition of subtropical terrestrial ants focusing on the particular response of the native red imported fire ant, Solenopsis invicta Buren. Unbaited pitfall traps were used to capture worker ants in 25 grazed and 20 nongrazed sites. Fifty ant species were collected. The savanna showed more species, individuals, biomass, and functional groups of ants than the grassland. S. invicta was the most frequently captured (61.4%) and numerically dominant species; however Camponotus punctulatus punctulatus Mayr showed the highest biomass. Grazing simplified vegetation structure in both habitats, but its impact on vegetation seemed only to promote a higher total biomass especially in the grassland, and/or functional groups, favoring occurrence of hot-climate specialists in the savanna. This study revealed that habitat type strongly affected the organization of the terrestrial ant assemblages at the INR. However, as in other studies, we did not find clear evidence that habitat modification by grazing significantly affected terrestrial ant assemblages. The weak grazing influence could be the consequence of the short enclosure time as to recover the original ant communities, the differential response of ant species to habitat type, and/or the resilience of ants.
Pleistocene Diversification of theOdontophotopsis unicornisSpecies-Group (Hymenoptera: Mutillidae)
Authors: Wilson Joseph S , Pitts James P 
Published: June 2010

AbstractMany recent studies have suggested that a majority of the species-level diversification in the arid-adapted North American biota was driven by mountain-building events that took place in the late Neogene (15-2 Ma). This assertion was tested with a phylogeographic analysis of the Odontophotopsis unicornis species-group by using the rDNA internal transcribed spacer regions internal transcribed spacer (ITS)1 and ITS2 and a Bayesian methodology. The validity of the two species in this species-group [Odontophotopsis unicornis Schuster and Odontophotopsis erebus (Melander) ] was tested both morphologically and molecularly. The female of O. unicornis was previously unknown and was associated with the male using molecular data. Here, O. unicornis is described and compared with that of its sister species O. erebus. Divergence dates for the O. unicornis species-group were estimated using the programs r8s and BEAST and calibrated with fossils from Dominican amber. These analyses resulted in a well supported phylogenetic tree that reinforces the notion that O. unicornis and O. erebus are distinct species. Little or no phylogenetic structuring was found among populations of either species. The species in this group seem to have evolved in the middle Pleistocene (≈1 Ma). The lack of phylogeographic structuring in each of the species of the O. unicornis speciesgroup is probably due to the recent origin of these species. This analysis represents one of the few instances of Pleistocene age species-level divergences in desert-adapted taxa.
Influence of Male Age and Diet on Reproductive Potential of Orius laevigatus (Hemiptera: Anthocoridae)
Authors: Bonte Maarten , Clercq Patrick De 
Published: June 2010

Abstract
When assessing the reproductive potential of laboratory-reared predatory insects, the role of males is often neglected, although they may have a significant impact on the reproductive output of their female mates. The current study investigated the effect of age and diet of males on the reproductive capacity of the anthocorid predator Orius laevigatus (Fieber) (Hemiptera: Anthocoridae). The tested diets consisted of eggs of Anagasta kuehniella (Zeller) and an egg yolk-based artificial diet. Regardless of their diet, virgin females did not produce any mature oocytes, indicating that mating is required to complete ovarian development. Food source and age of the males affected the reproductive potential of their female mates. When both males and females were offered the artificial diet, male age had a significant effect on female oocyte counts. Virgin females that were mated with 0-d-old virgin males produced fewer offspring than those mated with 8-d-old virgin males. In contrast, male age did not affect fecundity when the males were fed A. kuehniella eggs. The implications of the findings for the mass production of O. laevigatus are discussed.
Revision of the Family Helotidae (Coleoptera: Cucujoidea): V. Species Group Classification of the Genus Neohelota Ohta and Revisions of N. laevigata and N. helleri Species Groups
Authors: Lee C-F 
Published: June 2010

Abstract
Species of the genus Neohelota are classified into six species groups, and 60 species are recognized. Taxonomy of the laevigata and helleri species groups is presented in detail. Two new species are described: N. viklundi sp. nov. from Myanmar and N. satoi sp. nov. from Laos. A lectotype is designated for N. tibialis Ritsema. Protibiae, genitalia, aedeagal internal sacs, eighth abdominal tergites, and fifth abdominal ventrites are illustrated for all species.