bluuebunny/crossref_metadata_2025_split huggingface dataset:
Photospheric parameters and C abundances in solar-like stars with and without planets
Authors: Da Silva Ronaldo , Milone André 
Published: March 2010

AbstractWe have been analyzing a large sample of solar-like stars with and without planets in order to homogeneously measure their photospheric parameters and Carbon abundances. Our sample contains around 200 stars in the solar neighborhood observed with the ELODIE spectrograph, for which the observational data are publicly available. We performed spectral synthesis of prominent bands of C2 and CI lines, aiming to accurately obtain the C abundances. We intend to contribute homogeneous results to studies that compare elemental abundances in stars with and without known planets. New arguments will be brought forward to the discussion of possible chemical anomalies that have been suggested in the literature, leading us to a better understanding of the planetary formation process. In this work we focus on the C abundances in both stellar groups of our sample.
Stellar Parameters for a Sample of Stars with Planets
Authors: Ghezzi Luan , Cunha Katia , de Araújo Francisco X. , Smith Verne V. , de la Reza Ramiro , Schuler Simon 
Published: March 2010

AbstractThe study of chemical abundances in stars with planets is an important ingredient for the models of formation and evolution of planetary systems. In order to determine accurate abundances, it is crucial to have a reliable set of atmospheric parameters. In this work, we describe the homogeneous determination of effective temperatures, surface gravities and iron abundances for a large sample of stars with planets as well as a control sample of stars without giant planets. Our results indicate that the metallicity distribution of the stars with planets is more metal rich by ~0.13 dex than the control sample stars.
On the origin of giant planets and their hosts
Authors: Haywood Misha 
Published: March 2010

AbstractThe correlation between stellar metallicity and giant planets has been tentatively explained by the possible increase of planet formation probability in stellar disks with enhanced amount of metals. There are two caveats to this explanation. First, giant stars with planets do not show a metallicity distribution skewed towards metal-rich objects, as found for dwarfs. Second, the correlation with metallicity is not valid at intermediate metallicities, for which it can be shown that giant planets are preferentially found orbiting thick disk stars.None of these two peculiarities is explained by the proposed scenarios of giant planet formation. We contend that they are galactic in nature, and probably not linked to the formation process of giant planets. It is suggested that the same dynamical effect, namely the migration of stars in the galactic disk, is at the origin of both features, with the important consequence that most metal-rich stars hosting giant planets originate from the inner disk. A planet-metallicity correlation similar to the observed one is easily obtained if stars from the inner disk have a higher percentage of giant planets than stars born at the solar radius, with no specific dependence on metallicity. We propose that the density of H2 in the inner galactic disk (the molecular ring) could play a role in setting the high percentage of giant planets that originate from this region.
Photostability of gas- and solid-phase biomolecules under astrophysical analog soft X-rays field
Authors: Pilling S. , Andrade D. P. P. , Marinho R. T. , do Nascimento E. M. , Boechat-Roberty H. M. , de Castilho R. B. , de Souza G. G. B. , Coutinho L. H. , Cavasso-Filho R. L. , Lago A. F. , de Brito A. N. 
Published: March 2010

AbstractWe present experimental studies on the interaction of soft X-rays on gas-phase and solid-phase amino acids and nucleobases in an attempt to verify if these molecules (supposed to be formed in molecular clouds/protostellar clouds) can survive long enough to be observed or even to be found in meteorites. Measurements have been undertaken employing 150 eV photons under high vacuum conditions at the Brazilian Synchrotron Light Laboratory (LNLS). The produced ions from the gas-phase experiments (glycine, adenine and uracil) have been mass/charge analyzed by time-of-flight spectrometer. The analysis of solid phase samples (glycine, DL-proline, DL-valine, adenine and uracil) were performed by a Fourier transform infrared spectrometer coupled to the experimental chamber. Photodissociation cross sections and halflives were determined and extrapolated to astrophysical environments. The nucleobases photostability was up to two orders of magnitude higher than for the amino acids.
Radiolysis of ammonia-containing ices by heavy cosmic rays inside dense molecular clouds
Authors: Pilling Sergio , Duarte Eduardo Seperuelo , da Silveira Enio F. , Balanzat Emmanuel , Rothard Hermann , Domaracka Alicja , Boduch Philippe 
Published: March 2010

AbstractWe present experimental studies on the interaction of heavy, highly charged and energetic ions (46 MeV 58Ni13+) with interstellar ammonia-containing (H2O:NH3:CO) ice analog in an attempt to simulate the physical chemistry induced by heavy ion cosmic rays inside dense astrophysical environments. The measurements were performed at the heavy ion accelerator GANIL in Caen, France. In-situ analysis have been performed by a Fourier transform infrared spectrometer. The averaged values for the dissociation cross section of water, ammonia and carbon monoxide are determined and the estimated half life for the studied species inside dense molecular clouds is 2-3 × 106 years. The IR spectra of organic residue produced by the radiolysis have revealed, at room temperature, five bands that are tentatively assigned to vibration modes of the zwitterionic glycine (NH3+CH2COO−).
Spectroscopic surveys to measure Galaxy evolution
Authors: Gilmore Gerard 
Published: March 2010

AbstractGalaxies are complex non-linear systems, evolving on all time-scales. Isolating whatever set of physical processes was important at each major phase of their evolution requires artefacts which resolve the timescales of dominant physical processes. These are the chemical elements, and stellar kinematics. I consider what surveys are required to make progress in Galaxy evolution mapping, in the era of Gaia.
Relationship between depth and morphology of foraminifera in Abderaz Formation, IRAN
Authors: Shafiee Ardestani Meysam , Asgharian rostami Masoud , Balmaki Behzad , Balmaki Behnaz 
Published: March 2010

AbstractAbderaz Formation at its type section with an age of Turonian-early Campanian and a thickness of 300 m contains light grey shale and marl. The study of the planktonic foraminifera in isolated form led to differentiate three morphotype groups. The first group is characterized by trochospiral tests usually indicate shallow waters, the second group contains forms with strong ornamentations and the primary keels representing mid waters and finally compact trochospiral tests with keels known as deep water indices are included in the third group. Studies on the morphotypes showed a regressive cycle for Abderaz Formation. In the present study the depth of Abderaz Formation was determined using planktonic morphotypes. As Results of the study all changes in test of planktons were observed in related to the water depth of their ecosystem. The data of the represented research are in confirmation with the Pascal Law.
Current Issues: Training To Ensure Quality Practicum Supervision of Graduate Students
Authors: Norton Jessica J. 
Published: March 2010

Abstract
Appropriate supervision and effective clinical instruction are essential to the education of future speech-language pathologists. Practicum supervisors assist graduate students with their integration of academic knowledge and clinical skills, which leads to their independent thinking and problem solving, and ultimately to their demonstration of clinical competencies. Despite this vital role, many supervisors do not have the education and training to be proficient mentors. Therefore, Camtasia Studio was used at the University of Virginia to create two short training programs (each 17 minutes in length) to support speech-language pathologists involved in supervisory roles at off-site facilities. Furthermore, survey results completed by these professionals following the initial trainings help to rationalize the need for additional trainings and more wide-spread instruction of speech-language pathologists who take on the role as clinical supervisor.
Business: Making Cents of Coding Systems: Billing for Professional Services
Authors: Nikjeh Dee Adams 
Published: March 2010

Abstract
Administrators and supervisors face daily challenges over issues such as program funding, service fees, correct coding procedures, and the ever-changing healthcare regulations. Receiving equitable reimbursement for speech-language pathology and audiology services necessitates an understanding of federal coding and reimbursement systems. This tutorial provides information pertaining to two major healthcare coding systems and explains the relationship of these systems to clinical documentation, the Medicare Physician Fee Schedule and equitable reimbursement. An explanation of coding edits and coding modifiers is provided for use in those occasional atypical situations when the standard use of procedural coding may not be appropriate. Also included in this tutorial is a brief discussion of the impact that the Medicare Improvements for Patients and Providers Act of 2008 (HR 6331 Medicare Improvements for Patients and Providers Act [MIPPA], 2008) has had on the valuation of speech-language pathology procedure codes.
Supervision: Essentials of Collaboration
Authors: Livingston Amy 
Published: March 2010

Abstract
This article examines collaboration in the workplace, primarily in the educational setting. The article stresses the importance of examining one's own collaborative efforts in order to effectively mentor others. By analyzing the different aspects of collaboration and realizing the importance of working together with other professionals, mentors and supervisors can teach co-laboring or collaborating more successfully to those we mentor.
Audiology: Remediating Boundary Issues: Triangulation and Self-Care
Authors: Herd Corey L. , Waide Michael P. , Cohn Tracy J. 
Published: March 2010

Abstract
Audiologists fill multiple roles in the lives of their clients. The audiologist is the limited-time caretaker of the client's loved one, the knowledgeable expert about speech and hearing, and sometimes, the trusted confidant. The fiduciary relationship that exists between client and clinician, however, is inherently and intentionally one-sided. Unfortunately, professionals who struggle with self-care and who lack awareness of self may find themselves faced with crossing boundaries or entangled in the complex web of relationships in their clients' lives. In this article, the authors examine relationship triangles (triangulation) and knowledge of self and self care as they relate to the audiologist's role with client management.
Current Issues: Advanced Digital Technology for Supervising Graduate Clinicians
Authors: Tellis Glenn , Cimino Lori , Alberti Jennifer 
Published: March 2010

Abstract
The purpose of this article is to provide clinical supervisors with information pertaining to state-of-the-art clinic observation technology. We use a novel video-capture technology, the Landro Play Analyzer, to supervise clinical sessions as well as to train students to improve their clinical skills. We can observe four clinical sessions simultaneously from a central observation center. In addition, speech samples can be analyzed in real-time; saved on a CD, DVD, or flash/jump drive; viewed in slow motion; paused; and analyzed with Microsoft Excel. Procedures for applying the technology for clinical training and supervision will be discussed.
Dual coding in alternative reading frames correlates with intrinsic protein disorder
Authors: Kovacs Erika , Tompa Peter , Liliom Karoly , Kalmar Lajos 
Published: March 2010

Numerous human genes display dual coding within alternatively spliced regions, which give rise to distinct protein products that include segments translated in more than one reading frame. To resolve the ensuing protein structural puzzle, we identified 67 human genes with alternative splice variants comprising a dual-coding region at least 75 nucleotides in length and analyzed the structural status of the protein segments they encode. The inspection of their amino acid composition and predictions by the IUPred and PONDR® VSL2 algorithms suggest a high propensity for structural disorder in dual-coding regions. In the case of +1 frameshifts, the average level of disorder in the two frames is similarly high (47.2% in the ancestral frame, 58.2% in the derived frame, with the average level of disorder in human proteins being approximately 30%), whereas in the case of -1 frameshifts, there is a significant tendency to become more disordered upon shifting the frame (16.7% in the ancestral frame, 56.3% in the derived frame). The regions encoded by the derived frame are mostly disordered (disorder percentage > 50%) in 39 out of 62 cases, which strongly suggests that structural disorder enables these protein products to exist and function without the need of a highly evolved 3D fold. The potential advantages are also demonstrated by the appearance of novel functions and the high incidence of transcripts escaping nonsense-mediated decay. By discussing several examples, we demonstrate that dual coding may be an effective mechanism for the evolutionary appearance of novel intrinsically disordered regions with new functions.
Four generations of transition-state analogues for human purine nucleoside phosphorylase
Authors: Ho Meng-Chiao , Shi Wuxian , Rinaldo-Matthis Agnes , Tyler Peter C. , Evans Gary B. , Clinch Keith , Almo Steven C. , Schramm Vern L. 
Published: March 2010

Inhibition of human purine nucleoside phosphorylase (PNP) stops growth of activated T-cells and the formation of 6-oxypurine bases, making it a target for leukemia, autoimmune disorders, and gout. Four generations of ribocation transition-state mimics bound to PNP are structurally characterized. Immucillin-H (

, first-generation) contains an iminoribitol cation with four asymmetric carbons. DADMe-Immucillin-H (

, second-generation), uses a methylene-bridged dihydroxypyrrolidine cation with two asymmetric centers. DATMe-Immucillin-H (

, third-generation) contains an open-chain amino alcohol cation with two asymmetric carbons. SerMe-ImmH (

, fourth-generation) uses achiral dihydroxyaminoalcohol seramide as the ribocation mimic. Crystal structures of PNPs establish features of tight binding to be; 1) ion-pair formation between bound phosphate (or its mimic) and inhibitor cation, 2) leaving-group interactions to N1, O6, and N7 of 9-deazahypoxanthine, 3) interaction between phosphate and inhibitor hydroxyl groups, and 4) His257 interacting with the 5′-hydroxyl group. The first generation analogue is an imperfect fit to the catalytic site with a long ion pair distance between the iminoribitol and bound phosphate and weaker interactions to the leaving group. Increasing the ribocation to leaving-group distance in the second- to fourth-generation analogues provides powerful binding interactions and a facile synthetic route to powerful inhibitors. Despite chemical diversity in the four generations of transition-state analogues, the catalytic site geometry is almost the same for all analogues. Multiple solutions in transition-state analogue design are available to convert the energy of catalytic rate enhancement to binding energy in human PNP.
Effect of diabetes and hypertension on left ventricular diastolic function in a high‐risk population without evidence of heart disease
Authors: Russo Cesare , Jin Zhezhen , Homma Shunichi , Rundek Tatjana , Elkind Mitchell S.V. , Sacco Ralph L. , Di Tullio Marco R. 
Published: March 2010

AimsTo assess the independent and combined effects of diabetes and hypertension on left ventricular (LV) diastolic function in a community‐based cohort at high cardiovascular risk.Methods and resultsTwo‐dimensional echocardiography was performed in 708 subjects from the Cardiac Abnormalities and Brain Lesions (CABL) study. Peak diastolic early (E) and late (A) transmitral flow, and tissue Doppler‐derived early mitral annulus velocity (E′) were recorded, and E/A and E/E′ ratios were calculated. The population was divided into four groups: those without hypertension or diabetes (HT−/DM−), those with only hypertension (HT), only diabetes (DM), and with hypertension plus diabetes (HT + DM). In multivariate analysis, hypertension and diabetes were independent predictors of worse diastolic function. The coexistence of hypertension and diabetes was associated with greater impairment of diastolic function (higher E/E′ ratio than HT−/DM−, HT, or DM, all P < 0.05), independent of covariates. The negative, synergistic effect of hypertension and diabetes on LV diastolic function was present both in lean participants and in overweight/obese ones. An E/E′ ratio >15, suggestive of increased LV filling pressure, was found in 2.2% of HT−/DM−, 8.9% of HT, 5.9% of DM, and 14.7% of HT + DM (P < 0.01).ConclusionHypertension and diabetes are independently associated with impaired LV diastolic function, independent of the effect of overweight/obesity and other covariates. Their coexistence results in a negative synergistic effect on LV diastolic mechanics and is associated with higher LV filling pressures than either condition alone.
Population pharmacokinetics of tamsulosin hydrochloride in paediatric patients with neuropathic and non‐neuropathic bladder
Authors: Tsuda Yasuhiro , Tatami Shinji , Yamamura Norio , Tadayasu Yusuke , Sarashina Akiko , Liesenfeld Karl‐Heinz , Staab Alexander , Schäfer Hans‐Günter , Ieiri Ichiro , Higuchi Shun 
Published: March 2010

WHAT IS ALREADY KNOWN ABOUT THIS SUBJECTTamsulosin is available on prescription as a modified release capsule in the US (Flomax®), and in most European countries for the treatment of the signs and symptoms of benign prostatic hyperplasia (BPH). The pharmacokinetics of tamsulosin hydrochloride (HCl) have been extensively studied in adults, but no pharmacokinetic data for paediatrics have been published to date.WHAT THIS STUDY ADDSA population pharmacokinetic model of tamsulosin HCl was developed in paediatric patients. Covariate analysis revealed that body weight and α1‐acid glycoprotein influenced both the apparent clearance and the apparent volume of distribution. This study confirms that there is no major difference in the pharmacokinetics of tamsulosin HCl between paediatrics (age range 2–16 years) and adults when the effect of body weight is taken into consideration.AIMSThe main objective of this study was to characterize the population pharmacokinetics of tamsulosin hydrochloride (HCl) in paediatric patients with neuropathic and non‐neuropathic bladder. A secondary objective was to compare the pharmacokinetics in paediatric patients and adults.METHODSTamsulosin HCl plasma concentrations in 1082 plasma samples from 189 paediatric patients (age range 2–16 years) were analyzed with NONMEM, applying a one compartment model with first‐order absorption. Based on the principles of allometry, body weight was incorporated in the base model, along with fixed allometric exponents. Covariate analysis was performed by means of a stepwise forward inclusion and backward elimination procedure. Simulations based on the final model were used to compare the pharmacokinetics with those in adults.RESULTSBeside thepriori‐implemented body weight, only α1‐acid glycoprotein had an effect on both apparent clearance and apparent volume of distribution. No other investigated covariates, including gender, age, race, patient population and concomitant therapy with anti‐cholinergics, significantly affected the pharmacokinetics of tamsulosin HCl (P< 0.001). The results of simulations indicated that the exposure in 12.5 kg paediatric patients was 3.5–4.3 fold higher than that in 70.0 kg adults. After a weight‐based dose administration, the exposure in paediatric patients was comparable with that in healthy adults.CONCLUSIONSA population pharmacokinetic model of tamsulosin HCl in paediatric patients was established and it described the data well. There was no major difference in the pharmacokinetics of tamsulosin HCl between paediatric patients (age range 2–16 years) and adults when the effect of body weight was taken into consideration.
Concurrent and construct validation of the short form of the Bruininks‐Oseretsky Test of Motor Proficiency and the Movement‐ABC when administered under field conditions: implications for screening
Authors: Spironello C. , Hay J. , Missiuna C. , Faught B. E. , Cairney J. 
Published: March 2010

AbstractRationale  Among the most widely used instruments to assess developmental co‐ordination disorder (DCD) in children are the Bruininks‐Oseretsky Test of Motor Proficiency (BOTMP) and the Movement Assessment Battery for Children (M‐ABC). However, there is little research on agreement between these tests, when administered to children in field‐based settings by trained non‐clinicians.Method  Ten of 75 schools participating in a larger study were randomly selected. All children in grade 4 (n= 340) in each of these schools were assessed at the same time using both the BOTMP‐SF and the M‐ABC in May of 2005. The order of tests was balanced, with an average gap in time between tests of 10–15 min. All tests were administered by trained research assistants.Results  The correlation between tests was moderate (r= 0.50, P < 0.01). Kappas were low at the fifth (k= 0.19) and 15th (k= 0.29) percentile cut‐points, which are generally used to identify cases of DCD. Re‐analysis using the relative improvement over chance (RIOC) statistic, however, revealed slightly better agreement at both cut‐points (fifth percentile, RIOC = 0.29; 15th percentile, RIOC = 0.47). Children who scored as probable for DCD on both motor tests, as well as on only the BOTMP‐SF, had higher body mass index, poorer physical fitness and lower levels of teacher‐reported physical ability than those positive for DCD on the M‐ABC only or those who scored negatively on both tests.Discussion  In general, the agreement between tests, even after adjustment for RIOC, was poor. Children identified with poor motor competence by both tests or by the BOTMP‐SF only are at particular risk for poor physical fitness, overweight/obesity and physical inactivity. It appears that each assessment measures different dimensions of motor ability but that under field‐based conditions the M‐ABC may be less useful when applied by non‐clinicians.