bluuebunny/crossref_metadata_2025_split huggingface dataset:
Le dégoût dans les campagnes de lutte contre le sida
Authors: Pezeril Charlotte 
Published: January 2011

Résumé Après avoir été particulièrement attentives aux questions de discrimination et de stigmatisation des personnes vivant avec le vih /sida, les campagnes médiatiques de prévention s’appuient à nouveau en France, depuis les années 2000, sur les ressorts du dégoût et de la peur à l’égard non seulement de la maladie, mais surtout des personnes atteintes. Cet article analyse quatre figures majeures du dégoût tel qu’il est mis en scène dans ces campagnes. Il tente de comprendre leur émergence et leurs articulations avec la politique de prévention et de lutte contre le sida, et plus largement avec la biopolitique et le gouvernement des corps.
A Unique Role of the Cholera Toxin A1-DD Adjuvant for Long-Term Plasma and Memory B Cell Development
Authors: Bemark Mats , Bergqvist Peter , Stensson Anneli , Holmberg Anna , Mattsson Johan , Lycke Nils Y. 
Published: January 2011

Abstract
Adjuvants have traditionally been appreciated for their immunoenhancing effects, whereas their impact on immunological memory has largely been neglected. In this paper, we have compared three mechanistically distinct adjuvants: aluminum salts (Alum), Ribi (monophosphoryl lipid A), and the cholera toxin A1 fusion protein CTA1-DD. Their influence on long-term memory development was dramatically different. Whereas a single immunization i.p. with 4-hydroxy-3-nitrophenyl acetyl (NP)-chicken γ-globulin and adjuvant stimulated serum anti-NP IgG titers that were comparable at 5 wk, CTA1-DD–adjuvanted responses were maintained for &gt;16 mo with a half-life of anti-NP IgG ∼36 wk, but &lt;15 wk after Ribi or Alum. A CTA1-DD dose-dependent increase in germinal center (GC) size and numbers was found, with &gt;60% of splenic B cell follicles hosting GC at an optimal CTA1-DD dose. Roughly 7% of these GC were NP specific. This GC-promoting effect correlated well with the persistence of long-term plasma cells in the bone marrow and memory B cells in the spleen. CTA1-DD also facilitated increased somatic hypermutation and affinity maturation of NP-specific IgG Abs in a dose-dependent fashion, hence arguing that large GC not only promotes higher Ab titers but also high-quality Ab production. Adoptive transfer of splenic CD80+, but not CD80−, B cells, at 1 y after immunization demonstrated functional long-term anti-NP IgG and IgM memory cells. To our knowledge, this is the first report to specifically compare and document that adjuvants can differ considerably in their support of long-term immune responses. Differential effects on the GC reaction appear to be the basis for these differences.
Cutting Edge: TIGIT Has T Cell-Intrinsic Inhibitory Functions
Authors: Joller Nicole , Hafler Jason P. , Brynedal Boel , Kassam Nasim , Spoerl Silvia , Levin Steven D. , Sharpe Arlene H. , Kuchroo Vijay K. 
Published: January 2011

Abstract
Costimulatory molecules regulate the functional outcome of T cell activation, and disturbance of the balance between activating and inhibitory signals results in increased susceptibility to infection or the induction of autoimmunity. Similar to the well-characterized CD28/CTLA-4 costimulatory pathway, a newly emerging pathway consisting of CD226 and T cell Ig and ITIM domain (TIGIT) has been associated with susceptibility to multiple autoimmune diseases. In this study, we examined the role of the putative coinhibitory molecule TIGIT and show that loss of TIGIT in mice results in hyperproliferative T cell responses and increased susceptibility to autoimmunity. TIGIT is thought to indirectly inhibit T cell responses by the induction of tolerogenic dendritic cells. By generating an agonistic anti-TIGIT Ab, we demonstrate that TIGIT can inhibit T cell responses directly independent of APCs. Microarray analysis of T cells stimulated with agonistic anti-TIGIT Ab revealed that TIGIT can act directly on T cells by attenuating TCR-driven activation signals.
Relationship Between Pain Catastrophizing Level and Sensory Processing Patterns in Typical Adults
Authors: Engel-Yeger Batya , Dunn Winnie 
Published: January 2011

AbstractOBJECTIVE. We examined the relationship between pain perception, as expressed by pain catastrophizing level, and sensory processing patterns among typical adults.METHOD. Two hundred ninety healthy adults participated in this study: 138 men and 152 women. Their ages ranged from 18 to 50 (mean age = 30.2 ± 6.8). All participants completed the Adolescent/Adult Sensory Profile and the Pain Catastrophizing Scale (PCS).RESULTS. PCS scores significantly correlated with Low Registration, Sensory Sensitivity, and Sensation Avoiding. Women had higher sensory sensitivity and a higher pain catastrophizing level than did men.CONCLUSION. Sensory processing patterns may be related to individual pain perception, as expressed in pain catastrophizing level. Intervention programs should take these factors into account to be more focused on the specific needs of each client, facilitate his or her optimal engagement in daily living activities, and elevate well-being.
Evaluating Driving as a Valued Instrumental Activity of Daily Living
Authors: Dickerson Anne E. , Reistetter Timothy , Davis Elin Schold , Monahan Miriam 
Published: January 2011

Abstract
The purpose of this translational research article is to illustrate how general practice occupational therapists have the skills and knowledge to address driving as a valued occupation using an algorithm based on the Occupational Therapy Practice Framework: Domain and Process (2nd ed.; American Occupational Therapy Association, 2008b). Evidence to support the model is offered by a research study. Participants were compared on their performance of complex instrumental activities of daily living (IADLs) and a behind-the-wheel driving assessment. A significant relationship was found between the process skills from the performance assessment and whether the driver passed, failed, or needed restrictions as indicated by the behind-the-wheel assessment. The evidence suggests that occupational therapists using observational performance evaluation of IADLs can assist in determining who might be an at-risk driver. The algorithm addresses how driver rehabilitation specialists can be used most effectively and efficiently with general practice occupational therapy practitioners meeting the needs of senior drivers.
Factors Associated With Therapists’ Involvement in Children’s Transition to Preschool
Authors: Myers Christine Teeters , Schneck Colleen M. , Effgen Susan K. , McCormick Katherine M. , Shasby Sharon Brandenburger 
Published: January 2011

Abstract
We identified factors associated with occupational therapists’ involvement as children receiving early intervention services transition into preschool. A survey was sent to members of the American Occupational Therapy Association’s School System Special Interest Section. The highest ranked factor for respondents in early intervention was understanding their role (mean [M]= 4.96, standard deviation [SD] = 1.26, n = 78) and for respondents in preschool programs it was having preschool staff value their participation (M = 4.84, SD = 1.46, n = 248). Preschool occupational therapists’ relationship with early intervention providers, employer-based supports, and knowledge of the transition process were significantly associated with their involvement in two transition planning areas: collaboration with early intervention programs (p &lt; .001) and family support (p &lt; .001). Findings suggest that practices that enhance relationships among programs influence occupational therapist involvement. Implications for formal training to support involvement in the transition process are discussed.
Caregiver Awareness of Prone Play Recommendations
Authors: Zachry Anne H. , Kitzmann Katherine M. 
Published: January 2011

AbstractWe examined caregiver awareness of the American Academy of Pediatrics’ prone play recommendation, determined the primary sources of the recommendation, and examined why some infants are not provided “tummy time.” Of caregivers, 25% were not aware of prone play recommendations, and one-fourth of that group was not aware of potential complications from limited tummy time. The primary sources of prone play information and potential complications were printed materials, then pediatricians. Of infants, 53% received ≤30 min; 35% were intolerant of the prone position. This study indicates that many caregivers are not aware of tummy time and complications that can occur if it is not provided. Health care professionals, including therapists, must educate parents on the importance of prone play and provide information on how to increase infant tolerance for prone play time.
Occupational Therapy Interventions for Work-Related Injuries and Conditions of the Forearm, Wrist, and Hand: A Systematic Review
Authors: Amini Debbie 
Published: January 2011

Abstract
A systematic review of the literature related to effective occupational therapy interventions in rehabilitation of individuals with work-related forearm, wrist, and hand injuries and illnesses was conducted as part of the Evidence-Based Literature Review Project of the American Occupational Therapy Association. This review provides a comprehensive overview and analysis of 36 studies that addressed many of the interventions commonly used in hand rehabilitation. Findings reveal that the use of occupation-based activities has reasonable yet limited evidence to support its effectiveness. This review supports the premise that many client factors can be positively affected through the use of several commonly used occupational therapy–related modalities and methods. The implications for occupational therapy practice, research, and education and limitations of reviewed studies are also discussed.
Effective Occupational Therapy Interventions in the Rehabilitation of Individuals With Work-Related Low Back Injuries and Illnesses: A Systematic Review
Authors: Snodgrass Jeff 
Published: January 2011

Abstract
A systematic review of the literature related to effective occupational therapy interventions in rehabilitation of individuals with work-related low back injuries and illnesses was carried out as part of the Evidence-Based Literature Review Project of the American Occupational Therapy Association. This review evaluated research on a broad range of occupational therapy–related intervention procedures and approaches. Findings from the review indicate that the evidence is insufficient to support or refute the effectiveness of exercise therapy and other conservative treatments for subacute and chronic low back injuries. The research reviewed strongly suggests that for interventions to be effective, occupational therapy practitioners should use a holistic, client-centered approach. The research supports the need for occupational therapy practitioners to consider multiple strategies for addressing clients’ needs. Specifically, interventions for individuals with low back injuries and illnesses should incorporate a biopsychosocial, client-centered approach that includes actively involving the client in the rehabilitation process at the beginning of the intervention process and addressing the client’s psychosocial needs in addition to his or her physical impairments. The implications for occupational therapy practice, research, and education are also discussed.
Creating a Clinically Useful Data Collection Form for the DASH Questionnaire
Authors: Lehman Leigh A. , Sindhu Bhagwant S. , Johnson Jessica , Velozo Craig A. 
Published: January 2011

AbstractPURPOSE. We generated a clinically useful data collection form for the Disabilities of the Arm, Shoulder, and Hand (DASH) questionnaire. This data collection form is designed to aid in measuring change and goal setting.METHOD. Rasch analysis was used to generate three data collection forms for constructs on the DASH (gross motor, fine motor, and symptoms; N = 960). A form was completed to represent the findings from 1 study participant. Admission and discharge data were illustrated for one of the three sections (gross motor activity). Possible goals were indicated on the admission form. The discharge form illustrates whether these goals have been achieved.RESULTS. Figures illustrate the utility of the forms in observing functional change from admission to discharge and how the forms aid in goal setting.CONCLUSION. Use of the data collection form has many positive implications. This type of form could aid in goal setting and treatment planning.
Use of Artificial Intelligence Chatbots in Interpretation of Pathology Reports
Authors: Steimetz Eric , Minkowitz Jeremy , Gabutan Elmer C. , Ngichabe Joan , Attia Hagar , Hershkop Mordechai , Ozay Fatih , Hanna Matthew G. , Gupta Raavi 
Published: May 2024

ImportanceAnatomic pathology reports are an essential part of health care, containing vital diagnostic and prognostic information. Currently, most patients have access to their test results online. However, the reports are complex and are generally incomprehensible to laypeople. Artificial intelligence chatbots could potentially simplify pathology reports.ObjectiveTo evaluate the ability of large language model chatbots to accurately explain pathology reports to patients.Design, Setting, and ParticipantsThis cross-sectional study used 1134 pathology reports from January 1, 2018, to May 31, 2023, from a multispecialty hospital in Brooklyn, New York. A new chat was started for each report, and both chatbots (Bard [Google Inc], hereinafter chatbot 1; GPT-4 [OpenAI], hereinafter chatbot 2) were asked in sequential prompts to explain the reports in simple terms and identify key information. Chatbot responses were generated between June 1 and August 31, 2023. The mean readability scores of the original and simplified reports were compared. Two reviewers independently screened and flagged reports with potential errors. Three pathologists reviewed the flagged reports and categorized them as medically correct, partially medically correct, or medically incorrect; they also recorded any instances of hallucinations.Main Outcomes and MeasuresOutcomes included improved mean readability scores and a medically accurate interpretation.ResultsFor the 1134 reports included, the Flesch-Kincaid grade level decreased from a mean of 13.19 (95% CI, 12.98-13.41) to 8.17 (95% CI, 8.08-8.25; t = 45.29; P &amp;lt; .001) by chatbot 1 and 7.45 (95% CI, 7.35-7.54; t = 49.69; P &amp;lt; .001) by chatbot 2. The Flesch Reading Ease score was increased from a mean of 10.32 (95% CI, 8.69-11.96) to 61.32 (95% CI, 60.80-61.84; t = −63.19; P &amp;lt; .001) by chatbot 1 and 70.80 (95% CI, 70.32-71.28; t = −74.61; P &amp;lt; .001) by chatbot 2. Chatbot 1 interpreted 993 reports (87.57%) correctly, 102 (8.99%) partially correctly, and 39 (3.44%) incorrectly; chatbot 2 interpreted 1105 reports (97.44%) correctly, 24 (2.12%) partially correctly, and 5 (0.44%) incorrectly. Chatbot 1 had 32 instances of hallucinations (2.82%), while chatbot 2 had 3 (0.26%).Conclusions and RelevanceThe findings of this cross-sectional study suggest that artificial intelligence chatbots were able to simplify pathology reports. However, some inaccuracies and hallucinations occurred. Simplified reports should be reviewed by clinicians before distribution to patients.
Automated segmentation of liver and hepatic vessels on portal venous phase computed tomography images using a deep learning algorithm
Authors: Li Shengwei , Li Xiao‐Guang , Zhou Fanyu , Zhang Yumeng , Bie Zhixin , Cheng Lin , Peng Jinzhao , Li Bin 
Published: May 2024

AbstractBackgroundCT‐image segmentation for liver and hepatic vessels can facilitate liver surgical planning. However, time‐consuming process and inter‐observer variations of manual segmentation have limited wider application in clinical practice.PurposeOur study aimed to propose an automated deep learning (DL) segmentation algorithm for liver and hepatic vessels on portal venous phase CT images.MethodsThis retrospective study was performed to develop a coarse‐to‐fine DL‐based algorithm that was trained, validated, and tested using private 413, 52, and 50 portal venous phase CT images, respectively. Additionally, the performance of the DL algorithm was extensively evaluated and compared with manual segmentation using an independent clinical dataset of preoperative contrast‐enhanced CT images from 44 patients with hepatic focal lesions. The accuracy of DL‐based segmentation was quantitatively evaluated using the Dice Similarity Coefficient (DSC) and complementary metrics [Normalized Surface Dice (NSD) and Hausdorff distance_95 (HD95) for liver segmentation, Recall and Precision for hepatic vessel segmentation]. The processing time for DL and manual segmentation was also compared.ResultsOur DL algorithm achieved accurate liver segmentation with DSC of 0.98, NSD of 0.92, and HD95 of 1.52 mm. DL‐segmentation of hepatic veins, portal veins, and inferior vena cava attained DSC of 0.86, 0.89, and 0.94, respectively. Compared with the manual approach, the DL algorithm significantly outperformed with better segmentation results for both liver and hepatic vessels, with higher accuracy of liver and hepatic vessel segmentation (all p < 0.001) in independent 44 clinical data. In addition, the DL method significantly reduced the manual processing time of clinical postprocessing (p < 0.001).ConclusionsThe proposed DL algorithm potentially enabled accurate and rapid segmentation for liver and hepatic vessels using portal venous phase contrast CT images.
Measuring functions of remembering public events: Development of a functions of collective memory questionnaire
Authors: Uzer Tuğba , Akdağ Simay , Dalmış Tuğçe , Özdemir Taha Veli , Demirtaşoğlu Dilara , Hekimci İpek , Özdemir Buğra Uğur , Polat Damla , Şenyurt Seran 
Published: May 2024

AbstractPrevious studies have demonstrated that people share their personal experiences with others for various purposes, such as gaining self‐understanding, socializing, and seeking solutions to current problems, among others. However, it remains unclear why people share collective experiences with others or whether they do so for reasons similar to those driving the sharing of personal experiences. In this study, we developed a questionnaire to identify and measure the motivations behind sharing collective experiences, including events like military coups, earthquakes, terrorist attacks, and more. The study involved 407 participants, spanning different age groups, from Turkey. The results reveal that (a) individuals share collective memories for reasons similar to those driving the sharing of individual memories and (b) the primary functions of collective memories include creating a collective identity, strengthening social bonds, fostering learning and understanding of past history, mitigating collective negative emotions, and guiding communities into the future.
Least squares adaptive control for uncertain system based on modified predictive model
Authors: He Huanhuan , Xie Rong , Yin Haitao , Fan Xue , Song Wanghang 
Published: May 2024

AbstractThis research addresses the tracking problem of least squares adaptive control for a class of nonlinear system with mismatched uncertainties. Different from most of existing solutions, modified predictive model is integrated into the proposed least squares adaptive control architecture. The significant role of modified predictive model in the adaptive control architecture is to achieve smooth transient by filtering out the high‐frequency oscillations, which cannot be canceled out by use of the hypothetical parameterized uncertainty models. Meanwhile, in order to guarantee tracking performance, a generalized restricted potential function (GRPF) is designed to constrain the weighted Euclidean norm of the predictive error of the modified predictive model to be less than a predefined scalar worst‐case bound. Finally, comparative simulations via the generic transport model (GTM) are conducted to examine the effectiveness of the proposed method. The results show that the transient performance and tracking performance of the controlled system can be improved simultaneously by the proposed method.
The “Heater” of “Cold” Tumors–Blocking IL‐6
Authors: Pu Weigao , Ma Chenhui , Wang Bofang , Zhu Weidong , Chen Hao 
Published: May 2024

AbstractThe resolution of inflammation is not simply the end of the inflammatory response but rather a complex process that involves various cells, inflammatory factors, and specialized proresolving mediators following the occurrence of inflammation. Once inflammation cannot be cleared by the body, malignant tumors may be induced. Among them, IL‐6, as an immunosuppressive factor, activates a variety of signal transduction pathways and induces tumorigenesis. Monitoring IL‐6 can be used for the diagnosis, efficacy evaluation and prognosis of tumor patients. In terms of treatment, improving the efficacy of targeted and immunotherapy remains a major challenge. Blocking IL‐6 and its mediated signaling pathways can regulate the tumor immune microenvironment and enhance immunotherapy responses by activating immune cells. Even transform “cold” tumors that are difficult to respond to immunotherapy into immunogenic “hot” tumors, acting as a “heater” for “cold” tumors, restarting the tumor immune cycle, and reducing immunotherapy‐related toxic reactions and drug resistance. In clinical practice, the combined application of IL‐6 inhibition with targeted therapy and immunotherapy may produce synergistic results. Nevertheless, additional clinical trials are imperative to further validate the safety and efficacy of this therapeutic approach.
Toosendanin Induces Lung Squamous Cell Carcinoma Cell Apoptosis and Inhibits Tumor Progression via the BNIP3/AMPK Signaling Pathway
Authors: Liu Fabing , Wang Guangxue , Zhao Liming , Chen Guohan , Dong Lin , Li Qinchuan , Zhu Dongyi 
Published: May 2024

AbstractLung squamous cell carcinoma (LUSC) is the second most common type of non‐small cell lung cancer. Toosendanin can target critical cancer cell survival and proliferation. However, the function of toosendanin in LUSC is limited. Cancer cell proliferative capacity is detected using cell morphology, colony formation, and flow cytometry. The invasiveness of the cells is detected by a Transwell assay, western blotting, and RT‐qPCR. Nude mice are injected with H226 (1×106) and received an intraperitoneal injection of toosendanin every 2 days for 21 days. RNA sequence transcriptome analysis is performed on toosendanin‐treated cells to identify target genes and signaling pathways. With increasing concentrations of toosendanin, the rate of cell proliferation decreases and apoptotic cells increases. The number of migrated cells significantly reduces and epithelial‐mesenchymal transition is reversed. Injection of toosendanin in nude mice leads to a reduction in tumor volume, weight, and the number of metastatic tumors. Furthermore, KEGG shows that genes related to the AMPK pathway are highly enriched. BNIP3 is the most differentially expressed gene, and its expression along with phosphorylated‐AMPK significantly increases in toosendanin‐treated cells. Toosendanin exerts anticancer effects, induces apoptosis in LUSC cells, and inhibits tumor progression via the BNIP3/AMPK signaling pathway.