bluuebunny/crossref_metadata_2025_split huggingface dataset:
Oleanolic acid improved intestinal immune function by activating and potentiating bile acids receptor signaling in E. coli-challenged piglets
Authors: Xue Chenyu , Jia Hongpeng , Cao Rujing , Cai Wenjie , Hong Weichen , Tu Jianing , Wang Songtao , Jiang Qianzhi , Bi Chongpeng , Shan Anshan , Dong Na 
Published: May 2024

Abstract
Background
Infection with pathogenic bacteria during nonantibiotic breeding is one of the main causes of animal intestinal diseases. Oleanolic acid (OA) is a pentacyclic triterpene that is ubiquitous in plants. Our previous work demonstrated the protective effect of OA on intestinal health, but the underlying molecular mechanisms remain unclear. This study investigated whether dietary supplementation with OA can prevent diarrhea and intestinal immune dysregulation caused by enterotoxigenic Escherichia coli (ETEC) in piglets. The key molecular role of bile acid receptor signaling in this process has also been explored.

Results
Our results demonstrated that OA supplementation alleviated the disturbance of bile acid metabolism in ETEC-infected piglets (P < 0.05). OA supplementation stabilized the composition of the bile acid pool in piglets by regulating the enterohepatic circulation of bile acids and significantly increased the contents of UDCA and CDCA in the ileum and cecum (P < 0.05). This may also explain why OA can maintain the stability of the intestinal microbiota structure in ETEC-challenged piglets. In addition, as a natural ligand of bile acid receptors, OA can reduce the severity of intestinal inflammation and enhance the strength of intestinal epithelial cell antimicrobial programs through the bile acid receptors TGR5 and FXR (P < 0.05). Specifically, OA inhibited NF-κB-mediated intestinal inflammation by directly activating TGR5 and its downstream cAMP-PKA-CREB signaling pathway (P < 0.05). Furthermore, OA enhanced CDCA-mediated MEK-ERK signaling in intestinal epithelial cells by upregulating the expression of FXR (P < 0.05), thereby upregulating the expression of endogenous defense molecules in intestinal epithelial cells.

Conclusions
In conclusion, our findings suggest that OA-mediated regulation of bile acid metabolism plays an important role in the innate immune response, which provides a new diet-based intervention for intestinal diseases caused by pathogenic bacterial infections in piglets.

Graphical Abstract
Hypoxia-induced NOS1 as a therapeutic target in hypercholesterolemia-related colorectal cancer
Authors: Qiu Weiqing , Zhao Li , Liu Hua , Xu Ping , Qian Changlin 
Published: May 2024

Abstract
Background
It is well established that hypercholesterolemia increases the risk of atherosclerosis, especially because it reduces the availability of nitric oxide (NO). However, the relationship between hypercholesterolemia and NO in regulating colorectal cancer development and progression remains unknown.

Methods
We conducted bioinformatics analysis, qRT-PCR, ChIP-qPCR assays, luciferase report assays, clonogenic survival assays, and multiple mouse models to investigate the function and mechanism of hypercholesterolemia in regulating NO signaling. Additionally, NOS inhibitors were used to evaluate the potential of therapeutic strategy in anti-tumor response.

Results
Here, we show that oxidized low-density lipoprotein (oxLDL) cholesterol and its receptor LOX-1 are essential for hypercholesterolemia-induced colorectal tumorigenesis. Mechanically, the oxLDL promotes the oxidant stress-dependent induction of hypoxia signaling to transcriptionally up-regulate NO synthase (NOS) especially NOS1 expression in colorectal cancer (CRC) cells. More importantly, our results suggested that selective inhibition of NOS1 with its specific inhibitor Nω-Propyl-L-arginine is a suitable therapeutic strategy for hypercholesterolemia-related CRC with both efficacy and toxicity reduction.

Conclusions
Our findings established that hypercholesterolemia induces the oxidant stress-dependent induction of hypoxia signaling to transcriptionally up-regulate NOS1 expression in CRC cells, and the clinically applicable NOS1 inhibitor Nω-Propyl-L-arginine represents an effective therapeutic strategy for hypercholesterolemia-related CRC.
Industry Peer Information and the Equity Valuation Accuracy of Firms Emerging from Chapter 11
Authors: Fang Bingxu , Saiy Sasan , Vyas Dushyantkumar 
Published: May 2024

Valuation plays a central role in determining Chapter 11 reorganization outcomes. However, obtaining accurate valuation estimates of reorganized firms is challenging because of limited firm-specific market-based information and the oft-conflicting incentives of claimholders. We examine the role of industry peer information in reducing misvaluations and its implications for unintended interclaimant wealth transfers and postreorganization performance. First, we find that the availability of relevant industry peer information is negatively associated with equity valuation errors for firms emerging from Chapter 11. Cross-sectional results suggest that the relation between industry peer information and valuation errors varies substantially with debtors’ information environment and case characteristics. Second, we find that industry peer information quality is associated with better ex post financial performance of emerged firms because of lower overvaluation. Finally, we document the role of industry peer information in substantially reducing the frequency and magnitude of unintended wealth transfers between claimants arising from equity valuation errors. This paper was accepted by Suraj Srinivasan, accounting. Funding: The authors appreciate financial support from the Social Sciences and Humanities Research Council of Canada [Grant 435-2020-0583] and the Canadian Academic Accounting Association. B. Fang acknowledges financial support from the Della Suantio Fellowship. Supplemental Material: The online appendix and data files are available at https://doi.org/10.1287/mnsc.2022.01233 .
An Iterative Adaptive Dynamic Programming Approach for Macroscopic Fundamental Diagram-Based Perimeter Control and Route Guidance
Authors: Chen Can , Geroliminis Nikolas , Zhong Renxin 
Published: May 2024

Macroscopic fundamental diagrams (MFDs) have been widely adopted to model the traffic flow of large-scale urban networks. Coupling perimeter control and regional route guidance (PCRG) is a promising strategy to decrease congestion heterogeneity and reduce delays in large-scale MFD-based urban networks. For MFD-based PCRG, one needs to distinguish between the dynamics of (a) the plant that represents reality and is used as the simulation tool and (b) the model that contains easier-to-measure states than the plant and is used for devising controllers, that is, the model-plant mismatch should be considered. Traditional model-based methods (e.g., model predictive control (MPC)) require an accurate representation of the plant dynamics as the prediction model. However, because of the inherent network uncertainties, such as uncertain dynamics of heterogeneity and demand disturbance, MFD parameters could be time-varying and uncertain. Conversely, existing data-driven methods (e.g., reinforcement learning) do not consider the model-plant mismatch and the limited access to plant-generated data, for example, subregional OD-specific accumulations. Therefore, we develop an iterative adaptive dynamic programming (IADP)-based method to address the limited data source induced by the model-plant mismatch. An actor-critic neural network structure is developed to circumvent the requirement of complete information on plant dynamics. Performance comparisons with other PCRG schemes under various scenarios are carried out. The numerical results indicate that the IADP controller trained with a limited data source can achieve comparable performance with the “benchmark” MPC approach using perfect measurements from the plant. The results also validate the IADP’s robustness against various uncertainties (e.g., demand noise, MFD error, and trip distance heterogeneity) when minimizing the total time spent in the urban network. These results demonstrate the great potential of the proposed scheme in improving the efficiency of multiregion MFD systems. Funding: The work was jointly funded by the National Natural Science Foundation of China under [Grant 72071214] (R. Zhong), the Dit4Tram project from the European Union’s Horizon 2020 Research and Innovation Programme under [Grant 953783] (N. Geroliminis), and the Research Student Attachment Programme of The Hong Kong Polytechnic University (C. Chen). Supplemental Material: The online appendix is available at https://doi.org/10.1287/trsc.2023.0091 .
The mediating effect of post-traumatic growth on the relationship between personality traits and resilience among a sample of Lebanese adults
Authors: Bitar Zeinab , Fekih-Romdhane Feten , Mahfoud Daniella , Fawaz Mirna , Hallit Souheil , Obeid Sahar 
Published: May 2024

BackgroundResilience plays a crucial role in mental health promotion and prevention, and was shown to be more represented in individuals who exhibit high levels of extraversion, openness, agreeableness, and conscientiousness. However, there is a lack of studies that comprehensively investigate the association between personality traits and resilience in Lebanon and Arab countries more broadly. The purpose of the present study was to complement the literature by investigating the direct and indirect effects between the five personality traits and resilience among a sample of Lebanese adults through the intermediary role of posttraumatic growth.MethodologyA cross-sectional study was carried out between May and July 2022, and enrolled 387 participants, all aged above 18 years old and recruited from all Lebanon governorates. The questionnaire used included socio-demographic questions, and the following scales: Connor-Davidson Resilience Scale (CD-RISC) to assess resilience, post traumatic growth (PTG), and Big Five Inventory (BFI-2). The SPSS software v.25 was used for the statistical analysis.ResultsPost-traumatic growth mediated the association between extraversion / agreeableness / conscientiousness and resilience. Higher extraversion / agreeableness / conscientiousness was significantly associated with more post-traumatic growth. Higher post-traumatic growth was significantly associated with more resilience. Extraversion, but not agreeableness and conscientiousness, was significantly and directly associated with more resilience.ConclusionFindings suggest that fostering PTG in individuals who experience adversity can help promote their resilience. Hence, it could be beneficial to design and apply programs aiming at supporting PTG among people who experience stressful and traumatizing situations, to consequently help them increase their sense of resilience.
Effects of neuraxial anesthesia in sitting and lateral positions on maternal hemodynamics in cesarean section: A systematic review and meta-analysis
Authors: Wen Cui , Xiang Ying-ying , Pang Qian-yun , Liu Hong-liang 
Published: May 2024

Study objective
During cesarean section, hypotension is a frequent side effect of spinal anesthesia. As a sitting or lateral position is required for spinal anesthesia performance, which of these two positions is more likely to cause intraoperative nausea, vomiting, and hypotension is still unknown. This meta-analysis compared the effects of these two positions on maternal hemodynamics and intraoperative nausea and vomiting.

Design
Systematic review and meta-analysis

Setting
Operating room

Patients
This study included 803 patients from 12 randomized controlled trials (RCTs).

Interventions
Neuraxial anesthesia in sitting position vs. lateral position.

Measurements
We chose RCTs comparing the effects of spinal anesthesia in the sitting and lateral positions on maternal hemodynamics by thoroughly searching PubMed, Embase, the Cochrane Library, and the Web of Science for articles published from database inception until October 31, 2022. The Cochrane Handbook was used to assess the methodological quality of each RCT; the results were analyzed using RevMan 5.4 software; and the Egger test was used to assess publication bias.

Main results
12 randomised controlled trials with 803 participants were ultimately included in the final analysis. No significant differences were observed between the two positions in terms of the incidence of hypotension(RR, 0.82; 95% CI, 0.58–1.16; P = 0.26; I2 = 66%), lowest systolic blood pressure(MD, -0.81; 95% CI, -7.38–5.75; P = 0.81; I2 = 86%), the dose of ephedrine(MD, -1.19; 95% CI, -4.91–2.52; P = 0.53; I2 = 83%), and number of parturients requiring ephedrine(RR, 0.97; 95% CI, 0.64–1.46; P = 0.88; I2 = 74%). For the incidence of intraoperative nausea and vomiting, there was no statistical difference between the two positions.

Conclusion
Parturients undergoing elective cesarean section under spinal anesthesia in the sitting or lateral position experienced similar incidence of hypotension, and there were no significant differences between these two positions in terms of the amount of ephedrine administered or the number of patients needing ephedrine. In both positions, the frequency of nausea and vomiting was comparable. The ideal position for anesthesia can be chosen based on the preferences and individual circumstances of the parturient and anesthesiologist.
Clozapine-Related Functional Bowel Obstruction: A Rare Adverse Effect Unmasking Quetiapine and Benztropine Interaction Raising Need for Bowel Surveillance
Authors: Tiwari Apoorv , Kambhatla Swathi , George Nathan , Anumolu Prathyusha , Malik Nikhale , Kambhatla Sujata 
Published: May 2024

ABSTRACT
Randomized controlled trials demonstrate a significant decline in hospital admissions and length of stay following the initiation of clozapine in individuals with bipolar disorder and schizophrenia, along with an increase in quality-adjusted life years. The morbidity and mortality associated with clozapine-induced gastrointestinal hypomotility (CIGH) is greater than agranulocytosis. Despite this, we only have clozapine risk evaluation and mitigation strategies by the US Food and Drug Administration for white cell count monitoring, but none exists for CIGH. Our case highlights CIGH due to multiple factors and recommendations to prevent it and enhance clozapine compliance by conducting a thorough literature review.
ALEGORI KEMATIAN DALAM PUISI JANĀZAH IMRA’AH KARYA ADŪNĪS: KAJIAN STRUKTURALISME GENETIK
Authors: Kurniawati Fauziyah , Annabil Muhammad Naufal 
Published: May 2024

Penelitian ini bertujuan untuk mengungkapkan alegori kematian dalam puisi Janāzah Imra’ah karya Adūnīs berdasarkan perpektif teori strukturalisme genetik dari Lucien Goldmann. Penelitian ini adalah penelitian kualitatif deskriptif dengan sumber data primer berupa puisi Janāzah Imra’ah dan sumber data sekunder berupa buku-buku pendukung lainnya. Peneliti menggunakan teknik baca dan catat untuk mengumpulkan data. Untuk mendapatkan data yang benar-benar valid, peneliti menggunakan teknik validasi data dengan menggunakan triangulasi data, ketekunan membaca, dan diskusi ahli; yakni menggali pemahaman terkait penelitian dari teman sejawat dan dosen yang ahli di bidangnya. Dalam menganalisis data, peneliti menggunakan analisis deskriptif yang meliputi reduksi, penyajian data dan verifikasi. Hasil penelitian ini adalah (a) fakta kemanusiaan ditegaskan melalui hakikat kematian dan refleksi cinta manusia terhadap kebaikan dalam hidup demi menujunya; (b) subjek kolektif dielaborasikan dalam paradoks makna kematian berdasarkan persepsi peran dan karakter setiap entitas; (c) pandangan dunia diuraikan dalam rekognisi kematian dengan letupan cinta yang menggerakkan manusia untuk menjawab segala persoalan hidup; (d) struktur karya sastra dijabarkan dalam bentuk interaksi antara personalitas tokoh dengan objek-objek dalam setiap sekat bait puisi; dan (e) dialektika pemahaman-penjelasan dirumuskan selaras dengan konsep puisi, yaitu pandangan dunia pengarang tentang rekognisi kematian dengan letupan cinta yang menggerakkan manusia untuk menjawab segala persoalan hidup digunakan untuk menjelaskan strukturasi karya sastra.
REVISITED CULTURAL HERITAGE & ARCHITECTURAL HERITAGE PREFERENCES TO LEVERAGE SUSTAINABLE TOURISM PERFORMANCE: EMPIRICAL RESEARCH ON INDONESIA WORLD HERITAGE SITES
Authors: Batu Kardison Lumban , Almadana Aulia Vidya 
Published: May 2024

Present study investigated the local benevolence uniqueness (LBU) and Aesthetical Environmental Look (AEL) on Sustainable Tourism Performance (STP) mediated by Revisited Cultural Heritage Value (RCHV) & Architectural Heritage Preferences (AHP. Data was gathering through survey with questionnaires based from January to June 2022, also questionnaires were distributed to email as well as other social media platform with google forms. Data collection is gained from the domestics’ tourists who have made traveling more than twice and visiting cultural heritage sites. 500 questionnaires were sent and 400 were returned and 383 could be used for further analysis. with non-purposive sampling and purposive sampling technique, respondents should have made traveling). Structural Equation Modeling (SEM) with AMOS 22 was deployed to analyze data. Statistical outputs demonstrated the research findings showing all the proposed hypotheses have significant impact on sustain tourism performance.
The effects of wearing face masks on the perception and mood of male healthy male adults during treadmill running: A pilot study
Authors: Hidaka Kento , Sonoda Shogo , Yamaguchi Taiki , Kose Yuka , Hyodo Kazuki , Oda Kazuto , Eshima Hiroaki 
Published: May 2024

AbstractIn the past few years, the face mask has been recommended for the prevention of exposing others to COVID‐19. Wearing a face mask may have the potential to increase dyspnea and discomfort during exercise; however, controversy exists on whether wearing face masks during exercise affects exercise performance, perception, and mood in runners. We investigated the physiological and perceptual responses of healthy male adults who had experienced long‐distance running while exercising at different intensities. Nine healthy young adults who were long‐distance runners wearing surgical face mask conducted an incremental treadmill protocol. The protocol was three 6‐min stages (20%, 40%, and 60% of maximal heart rate, respectively). The rating of perceived exertion (RPE) and the feeling scale (FS) were measured. RPE was higher in mask condition than in unmask condition (No mask vs. Face mask, light; 8.22 vs. 8.78, p = 0.615, middle; 10.00 vs. 10.78, p = 0.345, high; 12.33 vs. 13.67, p = 0.044.), while FS was not different between conditions. The present study shows that wearing a mask may increase rating of perceived exertion and discomfort when the exercise intensity exceeds a certain threshold in healthy male adults who have experienced long‐distance running.
Response relationships between the color parameters and chemical compositions of heat-treated wood
Authors: Liu Meihong , Zhang Liangliang , Chen Jiang , Chen Shuang , Lei Yafang , Chen Zhangjing , Yan Li 
Published: May 2024

Abstract
The magnitudes of the color changes in heat-treated wood are closely related to the chemical composition of the wood, and changes in the chemical composition are the essential reasons for changes in the mechanical properties of heat-treated wood. The response relationships among the color parameters of heat-treated wood and the chemical composition were constructed to provide a scientific basis for regulating the mechanical properties with the color. The effects and linear correlations of the lightness indicators (L*) for poplar (Populus tomentosa Carr.) and spruce (Picea asperata Mast.) after heat treatment were related to the chemical compositions of the heat-treated woods by constructing relationships between the L* values. The relative content of cellulose in the heat-treated poplar downward trend and was significantly positively correlated with the L* value; however, the correlation with the L* value for the heat-treated spruce was insignificant. The L* value of the heat-treated wood was significantly positively correlated with the relative contents of hemicellulose, and was significantly negatively correlated with lignin. The L* value of the heat-treated wood had a superior response relationship with the crystallite sizes. Therefore, the constructed response relationship provides a theoretical basis for accurate and nondestructive testing of the mechanical properties of heat-treated wood by using the color parameters as rapid detection indicators.
Beyond Chinese Spy Balloons: Why We Need to Teach East Asian Studies in U.S. Homeland Security and Emergency Preparedness Programs
Authors: Young Benjamin R. 
Published: May 2024

Abstract
This article argues for the inclusion of more East Asia-focused content, particularly regarding China and North Korea, in homeland security and emergency preparedness (HSEP) undergraduate curricula. It contends that current programs overemphasize the post-9/11 counterterrorism paradigm while neglecting state-level threats, especially from China as an ascendant geopolitical rival. China poses multifaceted challenges through cyberattacks, intellectual property theft, economic coercion, and potential military contingencies, such as invading Taiwan. North Korea's nuclear program and cyber activities also jeopardize U.S. homeland security. To prepare future professionals, the article recommends adding a “state actor threats” core subject matter area covering the histories, cultures, and political dynamics underlying these nations’ antagonistic policies. Cultivating deeper cultural competency about U.S. strategic competitors in East Asia is crucial for bolstering national security. Holistic education reform is needed to align HSEP programs with contemporary global geopolitical realities beyond traditional terrorism subjects.
Logistics and Crises: Understanding Roman Military Logistics and Procedures from the Unit Level and Upwards in 2ndto 4thCenturies CE Egypt Using the Surviving ‘Paperwork’
Authors: Olshanetsky Haggai 
Published: May 2024

SummaryThe current article wishes to focus on receipts and reports from Roman Egypt in order to reconstruct the bureaucratic procedures in this region or, more precisely, the bureaucratic procedures of the Roman military logistical system, from the unit level and upwards. This examination will aid in understanding the complexity of the Roman system and the Roman mindset, while highlighting how the lack of modern technology was overcome to maintain a highly organised and vast Empire. This will strengthen and support the assumption that an office organising military supply and their records most probably existed at multiple levels; the nome, the province and Empire. Moreover, the article inspects whether the logistical system endured the many crises of the 2ndand 3rdcenturies CE. As there was no significant change during or after these events, this may indicate the resilience of the Roman system. It could also suggest that some of these crises were not deemed as such by the Romans, and/or that the military structure, especially its logistical-bureaucratic side, was not blamed for these military disasters.