bluuebunny/crossref_metadata_2025_split huggingface dataset:
Rescue Therapy for Failed Mechanical Thrombectomy in Acute Ischemic Stroke: A Pooled Analysis of the Society of Vascular and Interventional Neurology Registry
Authors: Rodriguez‐Calienes Aaron , Siddiqui Fazeel M. , Galecio‐Castillo Milagros , Mohammaden Mahmoud H. , Dolia Jaydevsinh N. , Grossberg Jonathan A. , Pabaney Aqueel , Hassan Ameer E. , Tekle Wondwossen G. , Saei Hamzah , Miller Samantha , Majidi Shahram , T. Fifi Johana , Valestin Gabrielle , Siegler James E. , Penckofer Mary , Zhang Linda , Sheth Sunil A. , Salazar‐Marioni Sergio , Iyyangar Ananya , Nguyen Thanh N. , Abdalkader Mohamad , Linfante Italo , Dabus Guilherme , Mehta Brijesh P. , Sessa Joy , Jumma Mouhammad A. , Sugg Rebecca M. , Linares Guillermo , Nogueira Raul G. , Liebeskind David S. , Haussen Diogo C. , Ortega‐Gutierrez Santiago 
Published: May 2024

ObjectiveWe aimed to evaluate the association between rescue therapy (RT) and functional outcomes compared to medical management (MM) in patients presenting after failed mechanical thrombectomy (MT).MethodsThis cross‐sectional study utilized prospectively collected and maintained data from the Society of Vascular and Interventional Neurology Registry, spanning from 2011 to 2021. The cohort comprised patients with large vessel occlusions (LVOs) with failed MT. The primary outcome was the shift in the degree of disability, as gauged by the modified Rankin Scale (mRS) at 90 days. Additional outcomes included functional independence (90‐day mRS score of 0–2), symptomatic intracranial hemorrhage (sICH), and 90‐day mortality.ResultsOf a total of 7,018 patients, 958 presented failed MT and were included in the analysis. The RT group comprised 407 (42.4%) patients, and the MM group consisted of 551 (57.5%) patients. After adjusting for confounders, the RT group showed a favorable shift in the overall 90‐day mRS distribution (adjusted common odds ratio = 1.79, 95% confidence interval [CI] = 1.32–2.45, p < 0.001) and higher rates of functional independence (RT: 28.8% vs MM: 15.7%, adjusted odds ratio [aOR] = 1.93, 95% CI = 1.21–3.07, p = 0.005) compared to the MM group. RT also showed lower rates of sICH (RT: 3.8% vs MM: 9.1%, aOR = 0.52, 95% CI = 0.28–0.97, p = 0.039) and 90‐day mortality (RT: 33.4% vs MM: 45.5%, aOR = 0.61, 95% CI = 0.42–0.89, p = 0.009).InterpretationOur findings advocate for the utilization of RT as a potential treatment strategy for cases of LVO resistant to first‐line MT techniques. Prospective studies are warranted to validate these observations and optimize the endovascular approach for failed MT patients. ANN NEUROL 2024;96:343–355
Influence of Donor Skeleton on Intramolecular Electron Transfer Amount for Efficient Perovskite Solar Cells
Authors: Geng Shengwei , Duan Jialong , Liu Naimin , Li Hui , Zhu Xixi , Duan Xingxing , Guo Qiyao , Dou Jie , He Benlin , Zhao Yuanyuan , Tang Qunwei 
Published: May 2024

AbstractThe passivation of the defects derived from rapid‐crystallization with electron‐donating molecules is always a prerequisite to obtain desirable perovskite films for efficient and stable solar cells, thus, the in‐depth understanding on the correlations between molecular structure and passivation capacity is of great importance for screening passivators. Here, we introduce the double‐ended amide molecule into perovskite precursor solution to modulate crystallization process and passivate defects. By regulating the intermediate bridging skeletons with alkyl, alkenyl and benzene groups, the results show the passivation strength highly depends on the spin‐state electronic structure that serves as an intrinsic descriptor to determine the intramolecular charge distribution by controlling orbital electron transfer from the donor segment to acceptor segment. Upon careful optimization, the benzene‐bridged amide molecule demonstrates superior efficacy on improving perovskite film quality. As a physical proof‐of‐concept, the carbon‐based, all‐inorganic CsPbI2Br solar cell delivers a significantly increased efficiency of 15.51 % with a remarkably improved stability. Based on the same principle, a champion efficiency of 24.20 % is further obtained on the inverted (Cs0.05MA0.05FA0.9)Pb(I0.93Br0.07)3 solar cell. These findings provide new fundamental insights into the influence of spin‐state modulation on effective perovskite solar cells.
Unveiling new thiazole‐clubbed piperazine derivatives as multitarget anti‐AD: Design, synthesis, and in silico studies
Authors: Nasr Eman E. , Tawfik Samar S. , Massoud Mohammed A. M. , Mostafa Amany S. 
Published: May 2024

AbstractNew thiazole‐clubbed piperazine derivatives were designed, synthesized, evaluated for their inhibitory capabilities against human acetylcholinesterase and butyrylcholinesterase (hAChE and/or hBuChE) and β‐amyloid (Aβ) aggregation, and investigated for their metal chelating potential as multitarget agents for the treatment of Alzheimer's disease. Compounds 10, 19–21, and 24 showed the highest hAChE inhibitory activity at submicromolar concentrations, of which compound 10 was the most potent with a half‐maximal inhibitory concentration (IC50) value of 0.151 μM. Compounds 10 and 20 showed the best hBuChE inhibitory activities (IC50 values of 0.135 and 0.103 μM, respectively), in addition to remarkable Aβ1–42 aggregation inhibitory activities and metal chelating capabilities. Both compounds were further evaluated against human neuroblastoma SH‐SY5Y and PC12 neuronal cells, where they proved noncytotoxic at their active concentrations against hAChE or hBuChE. They also offered a significant neuroprotective effect against Aβ25–35‐induced cytotoxicity in human neuroblastoma SH‐SY5Y cells. Compound 10 displayed acceptable physicochemical properties and could pass the blood–brain barrier. The molecular docking study revealed the good binding interactions of compound 10 with the key amino acids of both the catalytic active site and the peripheral anionic site of hAChE, explaining its significant potency.
High‐Yield Synthesis of Hierarchical SAPO‐34 by Recrystallization Method for Efficient Methanol‐to‐Olefin Reactions
Authors: Wu You , Zhang Junyi , Shi Ziyu , Chen Chong , Yue Xiaoyang , Sun Qiming 
Published: May 2024

AbstractProlonging the lifetime of SAPO‐34 catalysts and enhancing their olefin selectivity in methanol‐to‐olefin (MTO) reactions are critical yet challenging objectives. Here, a series of hierarchical SAPO‐34 catalysts were synthesized using a straightforward recrystallization method. The incorporation of triethylamine into the recrystallization mother liquor facilitated the formation of mesopores, achieving a high solid yield of up to 90%. Notably, the addition of phosphoric acid and ammonium polyvinyl phosphate alcohol during the recrystallization process significantly enhanced the crystallinity and regularity of the hierarchical SAPO‐34 crystals, consequently increasing the mesopore size. Due to the substantially improved mass transfer efficiency and moderated acidity, the SP34‐0.14P‐0.06R catalysts exhibited a prolonged lifetime of 344 min and 80.3% selectivity for ethylene and propylene at a weight hourly space velocity (WHSV) of 2 h−1. This performance markedly surpasses that of the parent SP34 catalyst, which demonstrated a lifetime of 136 min and a selectivity of 78.0%. Remarkably, the SP34‐0.14P‐0.06R maintained a lifetime of 166 min even at a high WHSV of 10 h−1, which is more than 5‐fold greater than that of the original microporous SP34. This research offers valuable insights into the design and development of hierarchically porous zeolites with high yields, enhancing the efficiency of MTO reactions and other applications.
Mechanism and potentialities of photothermal and photodynamic therapy of transition metal dichalcogenides (TMDCs) against cancer
Authors: Tyagi Neha , Arya Rajeshwar Kamal Kant , Bisht Dheeraj , Wadhwa Pankaj , Kumar Upadhyay Tarun , Kumar Sethiya Neeraj , Jindal Deepak Kumar , Pandey Sadanand , Kumar Deepak 
Published: May 2024

AbstractThe ultimate goal of nanoparticle‐based phototherapy is to suppress tumor growth. Photothermal therapy (PTT) and photothermal photodynamic therapy (PDT) are two types of physicochemical therapy that use light radiation with multiple wavelength ranges in the near‐infrared to treat cancer. When a laser is pointed at tissue, photons are taken in the intercellular and intracellular regions, converting photon energy to heat. It has attracted much interest and research in recent years. The advent of transition materials dichalcogenides (TMDCs) is a revolutionary step in PDT/PTT‐based cancer therapy. The TMDCs is a multilayer 2D nano‐composite. TMDCs contain three atomic layers in which two chalcogens squash in the transition metal. The chalcogen atoms are highly reactive, and the surface characteristics of TMDCs help them to target deep cancer cells. They absorb Near Infrared (NIR), which kills deep cancer cells. In this review, we have discussed the history and mechanism of PDT/PTT and the use of TMDCs and nanoparticle‐based systems, which have been practiced for theranostics purposes. We have also discussed PDT/PTT combined with immunotherapy, in which the cancer cell apoptosis is done by activating the immune cells, such as CD8+.
Proton pump inhibitors stabilize the expression of PD‐L1 on cell membrane depending on the phosphorylation of GSK3β
Authors: Gao Long , Liu Yuan , Liu Jiaying , Li Jiali , Li Haotian , Liu Yanyan , Meng Fang , Du Xiaohong , Gao Yufeng , Li Jiabin , Qin F. Xiao‐Feng 
Published: May 2024

AbstractBackgroundPreclinical and clinical evidence indicates that proton pump inhibitors (PPIs) may indirectly diminish the microbiome diversity, thereby reducing the effectiveness of immune checkpoint inhibitors (ICIs). Conversely, recent publications have shown that PPIs could potentially enhance the response to ICIs. The precise mechanism through which PPIs modulate the ICIs remains unclear. In this study, we discovered a novel molecular function of PPIs in regulating immune invasion, specifically through inducing PD‐L1 translocation in various tumor cells.MethodsC57BL/6 mice subcutaneous transplantation model is used to verify the potential efficacy of PPIs and PD‐L1 antibody. Western blotting analysis and phosphorylated chip are used to verify the alteration of PD‐L1‐related pathways after being treated with PPIs. The related gene expression is performed by qRT‐PCR and luciferase reporter analysis. We also collected 60 clinical patients diagnosed with esophageal cancer or reflux esophagitis and then detected the expression of PD‐L1 in the tissue samples by immunohistochemistry.ResultsWe observed that the IC50 of tumor cells in response to PPIs was significantly higher than that of normal epithelial cells. PPIs significantly increased the expression of PD‐L1 on cell membrane at clinically relevant concentrations. Furthermore, pre‐treatment with PPIs appeared to synergize the efficiency of anti‐PD‐L1 antibodies in mouse models. However, PPI administration did not alter the transcription or total protein level of PD‐L1 in multiple tumor cells. Using a phosphorylated protein chip, we identified that PPIs enhanced the phosphorylation of GSK3β, then leading to PD‐L1 protein translocation to the cell membranes. The capacity of PPIs to upregulate PD‐L1 was negated following GSK3β knockout. Furthermore, our clinical data showed that the PPIs use resulted in increased PD‐L1 expression in esophageal cancer patients.ConclusionWe mainly address a significant and novel mechanism that the usage of PPIs could directly induce the expression of PD‐L1 by inducing GSK3β phosphorylation and facilitate primary tumor progression and metastasis.
Validating the 2023 FIGO staging system: A nomogram for endometrioid endometrial cancer and adenocarcinoma
Authors: Feng Yifan , Miao Fulu , Li Yuyang , Li Min , Cao Yunxia 
Published: May 2024

AbstractBackgroundTo find the factors impacting overall survival (OS) prognosis in patients with endometrioid endometrial carcinoma (EEC) and adenocarcinoma and to establish a nomogram model to validate the 2023 International Federation of Obstetrics and Gynecology (FIGO) staging system for endometrial cancer.MethodsData were obtained from the Surveillance, Epidemiology, and End Results (SEER) training cohort. An independent validation cohort was obtained from the First Affiliated Hospital of Anhui Medical University between 2008 and 2023. Cox regression analysis identified independent prognostic factors for OS in EEC and adenocarcinoma patients. A nomogram predicting OS was developed and validated utilizing the C‐index, calibration curves, receiver operating characteristic (ROC) curves, and decision curve analysis (DCA). The relationship between the tumor grade and prognosis of EEC and adenocarcinoma was quantified using net reclassification improvement (NRI), propensity score matching (PSM), and Kaplan–Meier curves.ResultsCox regression analysis identified age, race, marital status, tumor grade, tumor stage, tumor size, and chemotherapy as independent prognostic factors for OS. A nomogram for predicting OS was developed based on these factors. The C‐indexes for the OS nomogram was 0.743 and 0.720 for the SEER training set and external validation set, respectively. The area under the ROC (AUC) for the OS nomogram was 0.755, 0.757, and 0.741 for the SEER data subsets and 0.844, 0.719, and 0.743 for the external validation subsets. Calibration plots showed high concordance between the nomogram‐predicted and observed OS. DCA also demonstrated the clinical utility of the OS nomogram. NRI, PSM, and survival analyses revealed that tumor grade was the most important histopathological factor for EEC and adenocarcinoma prognosis.ConclusionSeven independent prognostic variables for the OS of patients with EEC and adenocarcinoma were identified. The established OS nomogram has good predictive ability and clinical utility and validates the 2023 endometrial cancer FIGO staging system.
Multimodal Insights of Regeneration Dynamics of Spent Bimetallic Catalysts by Full Field Hyperspectral Quick‐EXAFS Imaging and Environmental Transmission Electron Microscopy
Authors: Briois Valérie , Nelayah Jaysen , La Fontaine Camille , Roudenko Olga , Beauvois Anthony , Passos Aline Ribeiro , Alloyeau Damien 
Published: May 2024

AbstractMultimodal measurements involving time‐resolved Ni and Cu K edges Quick‐EXAFS, time‐resolved hyperspectral Full Field Quick‐EXAFS imaging with micrometer spatial resolution and aberration‐corrected Environmental Scanning Transmission Electron Microscopy have been performed over a NiCu catalyst used for the ethanol steam reforming reaction to establish structure‐activity relationships after regeneration. Activated catalysts are composed of 5–10 nm monometallic nickel nanoparticles and larger bimetallic randomly alloyed NiCu nanoparticles (NPs). After 3 h time on reactive stream, the monitoring of the regeneration of the coked deactivated catalyst at 500 °C by Full Field hyperspectral XAS imaging evidences that the oxidative propagation front affects faster metallic Ni species than metallic Cu ones as a result of the stronger oxophilic character of the former compared to the latter. Furthermore, ESTEM characterization of the deactivated catalyst when passing from H2 to O2 atmosphere at 500 °C for burning coke deposits evidences the fragmentation of the Ni and NiCu‐NPs driven by the Kirkendall effect in the encapsulated coked catalyst. The resulting increase of specific surface of active species is assumed to be responsible for the activity boost observed after regeneration.
Using PFG‐NMR and iGC to Study Diffusion and Adsorption in Heterogeneous Catalysts
Authors: Thompson Emma S. , Graf Katja , Brendlé Eric , Schreyer Hannah , De Baerdemaeker Trees , Parvulescu Andrei‐Nicolae , Kellermeier Matthias 
Published: May 2024

AbstractMass transport in porous systems is inherently complex, but at the same also of utmost importance for large‐scale industrial processes such as heterogeneous catalysis. For each of the different length scales of diffusive motion potentially involved or relevant, specific characterization techniques have been developed and successfully applied over the years – including, but not limited to pulsed field gradient nuclear magnetic resonance (PFG‐NMR) spectroscopy, zero length column (ZLC) measurements and inverse gas chromatography (iGC). While each of these methods can deliver detailed information on certain types of diffusion, none of them are capable of delivering a full picture of mass transport across multiple length scales alone. In this context, the goal of the present work was to evaluate the technical feasibility and characterization potential of the hyphenated combination of PFG‐NMR and iGC in a coupled experimental setup. Challenges, advantages, and limitations of this approach are discussed using the example of propane adsorption and diffusion in two different zeolite catalysts (Mg(H)‐ZSM‐5 and Silicalite‐1). It is shown that the simultaneous detection of self‐diffusion on short length scales (as probed by PFG‐NMR) and transport diffusion covering longer distances (detectable by iGC) cannot be realized under the used conditions, essentially due to the lack of kinetic control at higher reactant loadings. The key advantage of the developed coupled setup is the ability of the iGC instrument to provide defined and readily variable levels of catalyst loading, which enables advanced pore connectivity studies by PFG‐NMR and yields thermodynamic data on reactant adsorption at the same time.
Protocol: The effect of restorative justice interventions for young people on offending and reoffending: A systematic review
Authors: Gaffney Hannah , Jolliffe Darrick , Eggins Elizabeth , Ferreira Joana Gomes , Skinner Guy , Ariel Barak , Strang Heather 
Published: May 2024

AbstractThis is the protocol for a Campbell systematic review. The objectives are as follows. The primary aim of this mixed methods review is to synthesise the available evidence regarding the effectiveness of restorative justice interventions (RJIs) for reducing offending and reoffending outcomes in children and young people. We are also particularly interested in the impact of RJIs on children and young peoples' violent offending and violent reoffending. A second aim of the review is to examine whether the magnitude of effectiveness of RJIs may be influenced by study characteristics such as the population (e.g., age, ethnicity, or sex), the form of intervention (e.g., face‐to‐face mediation compared to family group conferencing), the place of delivery of the intervention (e.g., in independent office, in court), implementation (e.g., trained facilitators, dose, fidelity) and methodology (e.g., randomised controlled trial). The third aim of the review is to synthesise the qualitative evidence about RJ to develop a better contextual understanding of how these programmes may work and to elucidate factors that might increase the efficacy and implementation of RJ interventions. The specific research questions this systematic review aims to address are: (1) Do RJ interventions reduce children and young people's involvement in offending or reoffending relative to a comparison group? [RQ1]. (2) Is there variation in the impact of different RJ approaches on young people's involvement in offending or reoffending? [RQ2]. (3) Is there variation in the impact of RJIs on children and young people's offending or reoffending depending on the characteristics of the participants taking part in the RJI (e.g., sex, age, ethnicity)? [RQ3]. (4) What characteristics of RJIs, influence the effectiveness of RJIs for children and young people's offending and reoffending? [RQ4]. (5) What are the most notable barriers and facilitators, as reported by participants (e.g., the victims, children/young people, or mediators who have taken part in an evaluation of an RJI, or those children or young people who were meant to take part in an evaluation but ultimately did not), to the implementation of RJIs to reduce later offending or reoffending? [RQ5].
Neural network approaches for rumor stance detection: Simulating complex rumor propagation systems
Authors: Li Hao , Yang Wu , Wang Wei , Wang Huanran 
Published: May 2024

SummaryThis research introduces a comprehensive suite of neural network models designed to tackle the challenging task of rumor stance detection within the framework of simulating complex rumor propagation systems. Our objective centers on accurately modeling the intricate structures of rumor dialogues and propagation patterns to identify user stances—whether they are in support, denial, questioning, or commenting on rumors. Unlike conventional methods that rely on simplistic keyword targeting and fail in the nuanced context of social networks, our models delve into the complexities of dialogue and propagation structures, offering a more precise and insightful analysis of rumor dynamics. In addressing the simulation and modeling of complex systems, our approach specifically focuses on the elaborate interaction networks that underpin rumor spread and reception. While our methodology does not directly engage with brain‐like computing paradigms, it reflects a similar level of sophistication in handling layered and complex information flows, analogous to cognitive processes in understanding and interpreting human communications. Employing a hierarchical attention mechanism, our models adeptly parse through multitiered dialogue sequences, effectively distinguishing between various indicators of user stances. This allows for a nuanced and detailed representation of the rumor ecosystem, significantly enhancing the accuracy of stance detection. Through rigorous testing on diverse datasets, our approach has demonstrated superior performance over existing models, thereby establishing a new benchmark in the field.
Real‐Time FRET‐Based Measurements of Ca2+/PKA Dynamics in Plasma Membrane Microdomains of Primary Hippocampal Neurons
Authors: Sobolczyk‐Prawda Marta , Boczek Tomasz 
Published: May 2024

AbstractBoth Ca2+ and protein kinase A (PKA) are multifaceted and ubiquitous signaling molecules, essential for regulating the intricate network of signaling pathways. However, their dynamics within specialized membrane regions are still not well characterized. By using genetically encoded fluorescent indicators specifically targeted to distinct plasma membrane microdomains, we have established a protocol that permits observing Ca2+/PKA dynamics in discrete neuronal microdomains with high spatial and temporal resolution. The approach employs a fluorescence microscope with a sensitive camera and a dedicated CFP/YFP/mCherry filter set, enabling the simultaneous detection of donor‐acceptor emission and red fluorescence signal. In this detailed step‐by‐step guide, we outline the experimental procedure, including isolation of rat primary neurons and their transfection with biosensors targeted to lipid rafts or non‐raft regions of plasma membrane. We provide information on the necessary equipment and imaging setup required for recording, along with highlighting critical parameters and troubleshooting guidelines for real‐time measurements. Finally, we provide examples of the observed Ca2+ and PKA changes in specific cellular compartments. The application of this technique may have significant implications for studying cross‐talk between second messengers and their alterations in various pathological conditions. © 2024 Wiley Periodicals LLC.