bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mediation analyses for the effect of antibodies in vaccination
Authors: Fay Michael P. , Follmann Dean A. 
Published: May 2024

Abstract
We review standard mediation assumptions as they apply to identifying antibody effects in a randomized vaccine trial and propose new study designs to allow the identification of an estimand that was previously unidentifiable. For these mediation analyses, we partition the total ratio effect (one minus the vaccine effect) from a randomized vaccine trial into indirect (effects through antibodies) and direct effects (other effects). Identifying

λ

\lambda

, the proportion of the total effect due to an indirect effect, depends on a cross-world quantity, the potential outcome among vaccinated individuals with antibody levels as if given placebo, or vice versa. We review assumptions for identifying

λ

\lambda

and show that there are two versions of

λ

\lambda

, unless the effect of adding antibodies to the placebo arm is equal in magnitude to the effect of subtracting antibodies from the vaccine arm. We focus on the case when individuals in the placebo arm are unlikely to have the needed antibodies. In that case, if a standard assumption (given confounders the potential mediators and potential outcomes are independent) is true, only one version of

λ

\lambda

is identifiable, and if not neither is identifiable. We propose alternatives for identifying the other version of

λ

\lambda

, using experimental design to identify a formerly cross-world quantity. Two alternative experimental designs use a three-arm trial with the extra arm being passive immunization (administering monoclonal antibodies), with or without closeout vaccination. Another alternative is to combine information from a placebo-controlled vaccine trial with a placebo-controlled passive immunization trial.
Increases in drug-related infant mortality in the United States
Authors: Kitsantas Panagiota , Densley Sebastian , Rao Meera , Sacca Lea , Levine Robert S. , Hennekens Charles H. , Mejia Maria C. 
Published: May 2024

Abstract

Objectives
We explored temporal trends in drug-related infant deaths in the United States (U.S.) from 2018 to 2022.

Methods
We used data from the Centers for Disease Control and Prevention Wide-ranging Online Data for Epidemiologic Research (WONDER). A total of 295 drug-involved infant deaths were identified from 2018 to 2022 (provisional mortality data for year 2022) based on the underlying cause of death.

Results
In the U.S. from 2018 to 2022, there was a significant 2.2-fold increase in drug-involved infant mortality. The observed increases were higher in non-Hispanic White and Black infants. The findings show that drug-involved infant deaths were more likely to occur in the postneonatal period, defined as ages 28–364 days (81.4 %) compared to the neonatal period. The most prevalent underlying causes of death included assault (homicide) by drugs, medicaments and biological substances (35.6 %) followed by poisoning due to exposure to narcotics and psychodysleptics (hallucinogens) (15.6 %). The most common multiple causes of drug-involved infant deaths were psychostimulants with abuse potential of synthetic narcotics.

Conclusions
Drug-related infant mortality has increased significantly from 2018 to 2022. These increases are particularly evident among White and Black infants and occurred predominantly in the postneonatal period. These findings require more research but also indicate the need to address drug-involved infant deaths as preventable clinical and public health issues. Effective strategies to reduce drug-involved infant deaths will require preventing and treating maternal substance use disorders, enhancing prenatal care access, and addressing broader social and behavioral risk factors among vulnerable maternal and infant populations.
Cost-effectiveness of ambroxol in the treatment of Gaucher disease type 2
Authors: Milosavljević Miloš N. , Gutić Medo , Janjić Vladimir , Veselinović Slađana , Djordjić Milan , Ivanović Radenko , Milosavljević Jovana , Janković Slobodan M. 
Published: May 2024

AbstractObjectiveOur aim was to compare the costs and efficacy of ambroxol in combination with imiglucerase with the costs and efficacy of imiglucerase only in the treatment of Gaucher disease type 2 (GD2) in the socio-economic settings of the Republic of Serbia, an upper-middle-income European economy.MethodsThe perspective of the Serbian Republic Health Insurance Fund was chosen for this study, and the time horizon was 6 years. The main outcomes of the study were quality-adjusted life years gained with ambroxol + imiglucerase and comparator, and direct costs of treatment. The study was conducted through the generation and simulation of the Markov chain model. The model results were obtained after Monte Carlo microsimulation of a sample with 1,000 virtual patients.ResultsTreatment with ambroxol in combination with imiglucerase was cost-effective when compared with imiglucerase only and was associated with positive values of net monetary benefit regardless of the onset of the disease. Such beneficial result for ambroxol and imiglucerase combination is primarily driven by the low cost of ambroxol and its considerable clinical effectiveness in slowing the progression of neural complications of GD2.ConclusionIf ambroxol and imiglucerase are used in combination for the treatment of GD2, it is more cost-effective than using imiglucerase alone.
Trajectory mapping of renal clear cell carcinoma transcriptomes identifies stage-independent predictors of favorable prognosis
Authors: Sheng Jie , Zheng Zihan , Li Xuejuan , Li Meijing , Zheng Feng 
Published: May 2024

Abstract

Objectives
The prognosis of clear cell renal cell carcinoma (ccRCC) is typically based on clinical stage, but it can vary for some patients. Transcriptomic analysis is vital for understanding ccRCC progression, though its correlation with the clinical stage in predicting prognosis is uncertain. We aim to employ trajectory inference to study ccRCC’s molecular progression and identify potential new markers for judging disease progression and prognosis.

Methods
Using a trajectory inference approach, we characterize the molecular progression profile of ccRCC based on transcriptome profiling. Additional pathway activity, immune response, and miRNA profiling scoring were integrated to identify possible drivers of trajectory progression.

Results
Scoring based on the trajectory demonstrates a significant improvement in patient prognosis prediction and identifies 10 risk factors in patients with low-grade tumors, and nine protective factors in patients with high-grade tumors. Mechanistically, we demonstrate an association between solute light carrier transporters are associated with ccRCC progression, with SLC7A5 expression being validated through immunohistochemistry to increase in metastatic patients.

Conclusions
Trajectory analysis of ccRCC transcriptomes can be used to model the molecular progression of disease and may assist in ccRCC prognosis. SLC7A5 is aberrantly expressed in ccRCC and may be a risk factor for poor prognosis.
Was wissen wir über die psychische Gesundheit von Studierenden in Deutschland?
Authors: Gusy Burkhard , Lesener Tino , Opper Felix , Wolter Christine 
Published: May 2024

Zusammenfassung
Bundesweite, belastbare Daten zum Thema Gesundheit bei Studierenden gibt es seit dem Projekt „Gesundheit Studierender in Deutschland 2017“. Weitere aktuellere hochschulübergreifende Befragungen lassen folgenden Trend erkennen: Der Anteil Studierender mit (sehr) guter Gesundheit hat sich deutlich verringert, die Anteile Studierender mit depressiven Symptomen sowie hoher (emotionaler) Erschöpfung sind größer geworden. Ob diese Entwicklungen (ausschließlich) der COVID-19-Pandemie zuzuschreiben sind, ist offen.
Studierendengesundheit und das Potenzial der Gesundheitsressource Naturerfahrung
Authors: Laemmert Pia , Laemmert Philipp , Tittlbach Susanne 
Published: May 2024

Zusammenfassung
Unterschiedliche Herausforderungen im Studienalltag bewirken, dass sich Studierende psychisch belastet fühlen. Auf Basis des salutogenetischen Ansatzes müssen Ressourcen identifiziert werden, die bei der Belastungsbewältigung unterstützen. Die Ergebnisse der Gesundheitsumfrage an der Universität Bayreuth zeigen, dass Frauen und Studierende im zweiten Studienjahr besonders belastet sind. Naturaufenthalte werden von den Studierenden als mögliche Belastungsbewältigung wahrgenommen und eingesetzt.
Studierende mit gesundheitlicher studienerschwerender Beeinträchtigung
Authors: Gerdes Frederike , Schwabe Ulrike , Steinkühler Julia , Kroher Martina 
Published: May 2024

Zusammenfassung
Der Beitrag nimmt Studierende mit gesundheitlicher studienerschwerender Beeinträchtigung an deutschen Hochschulen in den Blick. Mit Daten von „Die Studierendenbefragung in Deutschland: best: Studieren mit gesundheitlicher Beeinträchtigung“ werden Ergebnisse zur Zusammensetzung, zur Studienabbruchintention sowie zu Diskriminierungserfahrungen von Studierenden vorgestellt. Innerhalb dieser Gruppe zeigen sich beachtenswerte Unterschiede nach Art und Ausmaß der studienerschwerenden Beeinträchtigung.
Ansatzpunkte und Herausforderungen für ein ganzheitliches studentisches Gesundheitsmanagement an Hochschulen
Authors: Schäfer Markus , Dietz Pavel , Reichel Jennifer 
Published: May 2024

Zusammenfassung
Studierende sind eine wichtige Zielgruppe der Prävention und Gesundheitsförderung und als zukünftige Führungskräfte zentrale Multiplikatoren für das Thema Gesundheit in der Gesellschaft. Der Beitrag gibt einen Überblick über wichtige Gesundheitsaspekte bei Studierenden und deren Einflussfaktoren und zeigt Ansatzpunkte und Herausforderungen für ein evidenzbasiertes, ganzheitliches studentisches Gesundheitsmanagement an Hochschulen auf.
Digitale Inklusion an Hochschulen
Authors: Fisseler Björn 
Published: May 2024

Zusammenfassung
Digitale Inklusion an Hochschulen ist mehr als nur digitale Barrierefreiheit. Der Beitrag beleuchtet daher vier Dimensionen digitaler Inklusion. Technisch barrierefreie digitale Bildungsangebote sind für Studierende mit Behinderungen ebenso wichtig wie die Berücksichtigung unterschiedlicher Zugangs- und Erfahrungsniveaus der Studierenden. Zusätzlich zur hochschuldidaktischen Gestaltung müssen Hochschulen eine Strategie mit klaren Standards und gezielter Personalentwicklung erarbeiten.
Gesunde Hochschullehre – ein Paradigmenwechsel
Authors: Rupp Robert , Bucksch Jens 
Published: May 2024

Zusammenfassung
Gesundheitsförderung in der Hochschullehre wird traditionell nicht über einen didaktisch-pädagogischen Ansatz gewählt und geht mit einem Zusatzaufwand und Zeitverlust für den Bildungsauftrag einher. Im Paradigma einer guten gesunden Hochschullehre bleibt der Bildungsauftrag zentral und integriert Gesundheit beiläufig. Gesundheit wird in didaktischen Überlegungen zielführend eingebunden. Konzepte wie Stealth Interventions und Bedürfnisorientierte Hochschullehre bieten einen Orientierungsrahmen.
Präventionsbedarfe von Studierenden nach dem Gesundheitsstatus
Authors: Arnold Julia , Hollederer Alfons 
Published: May 2024

Zusammenfassung
In der Literatur ist wenig über die Bedarfe zur Gesundheitsförderung von Studierenden mit Gesundheitsbeeinträchtigung bekannt. Im März 2022 wurden Studierende mit und ohne gesundheitliche Beeinträchtigungen an der Universität Kassel zu verhaltens- und verhältnispräventiven Bedarfen befragt. Sie wünschen verstärkt Angebote zur psychischen Gesundheit sowie Verbesserung struktureller Bedingungen. Es empfiehlt sich der Aufbau eines studentischen Gesundheitsmanagements unter Berücksichtigung von beeinträchtigungsspezifischen Bedarfen.
Bewegungsaktivierung und Sitzzeitreduzierung im Hochschulalltag
Authors: Möckel Juliane , Wallmann-Sperlich Birgit , Rupp Robert , Bucksch Jens 
Published: May 2024

Zusammenfassung
Studierende sind durch langes Sitzen im Hochschulalltag gesundheitlichen Risiken ausgesetzt. Die Hochschullehre stellt einen vielversprechenden Ansatz für eine Reduzierung der Sitzzeiten und gleichzeitiges Fördern des Lernens durch bewegte Lehre und Studienzeiten dar. Interventionen sollten individuelle mit umwelt- und organisationsbezogenen Ansätzen koppeln. Projekte wie das Heidelberger Modell der bewegten Lehre und das Forschungskolleg Corpus zeigen innovative Ansätze im Bildungskontext auf.
Strange a construction: The “A egy N” in Hungarian
Authors: Fejes László , Molnár Cecília Sarolta , Sass Bálint 
Published: May 2024

AbstractThe paper gives a detailed description of the “A egy N” construction in Hungarian based on a thorough investigation of carefully collected corpus data. Utterances containing this construction express a speaker-related (mostly derogatory, but sometimes appreciative) value judgement. The morphological, syntactic, and pragmatic characteristics of the construction are presented. Furthermore, some formally and pragmatically similar constructions are also discussed and some misleading pieces of information in the earlier literature are debunked.
Józef Jakubowski (1899–1984) – activist in scout, community, and émigré organisations in the light of Polish and French archival resources
Authors: Pachowicz Anna 
Published: May 2024

The main purpose of this paper is to provide an insight into the life, activities, and preserved archival documents concerning Józef Jakubowski (1899–1984), whose work in support of Polish emigrants residing in France during the Second World War deserves highest recognition and respect. Jakubowski was born in Warsaw, where he spent his childhood, completed primary and secondary education, and began his studies at the Warsaw University of Technology in 1917. He was was actively involved in the scouting movement. His participation in the Polish–Soviet War forced him to leave the university . It was only in 1924 that he completed his higher education at another university, the Higher School of Commerce. His professional life also started in Warsaw, where he worked for the Association of Polish Merchants until 1939. His life was interrupted by the Second World War, and he decided to emigrate first to Switzerland and then to France. At that time of his life, he became involved with the Polish Red Cross. He was primarily involved in developing forms of aid and organising support for Poles in France. Once the Polish Red Cross was banned from further activities, he worked in the Welfare Society for the Poles in France. He cooperated with the Polish Resistance Movement in France and with military authorities on the evacuation of the Polish armed forces to England, as well as with many institutions, including the French Red Cross, the Department of Social Welfare for Foreigners, the International Refugee Organisation, and the Association of Polish Veterans. The archival documents concerning Jakubowski, surviving at the Central Archives of Modern Records in Warsaw and at the Polish Library in Paris, make it possible to reconstruct not only the facts of his life but also the events related to the functioning of the institutions, organisations, and associations he worked for.
Participation as “attingere” and Saint Thomas’ commentary on John 6:57
Authors: Von Voorst Johannes 
Published: May 2024

Saint Thomas Aquinas’ notion of participation is developed by Cornelio Fabro with the notion of ‘attingere’. In this essay I address the importance of ‘participare’ as attingere by uncovering it in Aquinas’ commentary on John 6:57. I introduce the notion of supernatural participation of grace and Fabro’s development of the notions of ‘attingere’ as ‘partecipare per similitudinem’ and ‘partecipare per operationem’ for a fuller understanding of the notion of participation that Fabro holds to be so essential. Afterwards we will see a concrete example in the uncovering of said notions in the Angelic Doctor’s commentary on a central verse of the Bread of Life discourse. Thus, we will be able to see both (a) the importance of the notion of ‘participare’ and ‘attingere’ in Saint Thomas’ work, and (b) have a more profound understanding of a key aspect of the thought of the Doctor Communis on grace and the Eucharist.
Protection of Sexual Violence Victims from the Perspective of Maqāṣid al-Sharī‘ah
Authors: Musyafa'ah Nur Lailatul , Nugraha Ahlam , Akbar Muhammad Ilham , Kurniawan Cecep Soleh 
Published: May 2024

The Witness and Victim Protection Agency (LPSK) in Indonesia plays a crucial role in safeguarding individuals affected by sexual violence. This article evaluates the LPSK’s authority in protecting sexual violence witnesses and victims through the lens of maqāṣid al-sharī‘ah. Employing a normative research approach, laws and regulations relevant to witness and victim protection were analyzed. Data, gathered via literature review, underwent deductive analysis. The study highlights that LPSK’s authority is governed by Laws No. 13/2006 (amended to No. 31/2014) on the Protection of Witnesses and Victims and Law No. 12/2022 on Criminal Acts of Sexual Violence. While these laws establish a vital framework for safeguarding sexual violence victims, their execution reveals notable weaknesses. To achieve the highest realization of maslaḥah in maqāṣid al-sharī‘ah, enhancing the protection of witnesses and victims is imperative. LPSK should focus on five key aspects: ḥifẓ al-dīn (protecting victims in accordance with God’s commandments, ḥifẓ al-nafs (providing medical protection, ḥifẓ al-nasl (administering punishment to perpetrators violating victims’ dignity, ḥifẓ al-'aql (imparting knowledge about victims’ rights, and ḥifẓ al-māl (supporting victims in obtaining restitution or material needs.
Analisis Kemampuan Pemecahan Masalah Numerasi Siswa Berdasarkan Tingkat Kecemasan Matematis
Authors: Susanti Seftyana Ayu , Budiarto Mega Teguh , Setianingsih Rini 
Published: May 2024

The descriptive study analyzed the skills of vocational school students with low, medium, and high levels of mathematical anxiety in terms of their problem-solving abilities. It used a qualitative approach to examine the various mathematical content strands and scientific contexts of the learners. Its findings were based on the notion of the problem-solving stage by Polya, Newman, as well as Krulik and Rudnik. The data collected during the study was gathered through a written test, which involved asking the participants to complete a questionnaire about their mathematical anxiety levels before they were asked to solve numeracy problems. The results of the study revealed that students with high levels of anxiety were more prone to experiencing problems with problem-solving. The findings of this study are valuable to mathematics educators and researchers. It is also expected to contribute to the development of effective problem-solving strategies for students.
Protein N-Glycans in Healthy and Sclerotic Glomeruli in Diabetic Kidney Disease
Authors: Veličković Dušan , Shapiro John P. , Parikh Samir V. , Rovin Brad , Toto Robert D. , Vazquez Miguel A. , Poggio Emilio D. , O'Toole John F. , Sedor John R. , Alexandrov Theodore , Jain Sanjay , Bitzer Markus , Hodgin Jeffrey , Veličković Marija , Sharma Kumar , Anderton Christopher R. ,   for the Kidney Precision Medicine Project
Published: May 2024

Key Points

Multiomics performed on diabetic kidney disease biopsies revealed five N-glycan signatures of sclerotic glomeruli that significantly differed compared with healthy glomeruli.Integrative spatial glycomics, proteomics, and transcriptomics revealed protein N-glycosylation characteristic of sclerotic glomeruli in diabetic kidney disease.

Background
Diabetes is expected to directly affect renal glycosylation; yet to date, there has not been a comprehensive evaluation of alterations in N-glycan composition in the glomeruli of patients with diabetic kidney disease (DKD).

Methods
We used untargeted mass spectrometry imaging to identify N-glycan structures in healthy and sclerotic glomeruli in formalin-fixed paraffin-embedded sections from needle biopsies of five patients with DKD and three healthy kidney samples. Regional proteomics was performed on glomeruli from additional biopsies from the same patients to compare the abundances of enzymes involved in glycosylation. Secondary analysis of single-nucleus RNA sequencing (snRNAseq) data were used to inform on transcript levels of glycosylation machinery in different cell types and states.

Results
We detected 120 N-glycans, and among them, we identified 12 of these protein post-translated modifications that were significantly increased in glomeruli. All glomeruli-specific N-glycans contained an N-acetyllactosamine epitope. Five N-glycan structures were highly discriminant between sclerotic and healthy glomeruli. Sclerotic glomeruli had an additional set of glycans lacking fucose linked to their core, and they did not show tetra-antennary structures that were common in healthy glomeruli. Orthogonal omics analyses revealed lower protein abundance and lower gene expression involved in synthesizing fucosylated and branched N-glycans in sclerotic podocytes. In snRNAseq and regional proteomics analyses, we observed that genes and/or proteins involved in sialylation and N-acetyllactosamine synthesis were also downregulated in DKD glomeruli, but this alteration remained undetectable by our spatial N-glycomics assay.

Conclusions
Integrative spatial glycomics, proteomics, and transcriptomics revealed protein N-glycosylation characteristic of sclerotic glomeruli in DKD.
Viabilidade de piscicultura orgânica em uma unidade de produção familiar em Laranjeiras do Sul, Paraná
Authors: Rossignol Vera Maria , Muelbert Betina , Stoffel Janete , Silva Letícia da Costa e 
Published: May 2024

O papel da agricultura familiar vem ganhando força, impulsionado através de debates embasados no desenvolvimento rural sustentável, na geração de trabalho e renda, contribuindo para a segurança alimentar. A piscicultura orgânica é uma atividade que pode ser desenvolvida por estes agricultores na promoção da sustentabilidade. Nesta perspectiva, o objetivo deste trabalho é analisar a viabilidade econômica/financeira, ambiental e social da produção de peixe em sistema orgânico em viveiros escavados com base em um estudo de caso. A metodologia adotada para alcançar os objetivos tem caráter exploratório e descritivo combinando pesquisa bibliográfica sobre estudos de análises da produção orgânica em geral e na piscicultura com estudo de caso. Em um período de dezesseis meses foi acompanhada a produção em sistema de policultivo de peixes, orgânico, utilizando alimentos naturais e provenientes da propriedade. Nas análises foram utilizadas técnicas de análise de viabilidade econômica: Valor Presente Líquido (VPL); Payback descontado (PB); Taxa Interna de Retorno (TIR); e Índice de Lucratividade (IL). O valor investido nos viveiros foi de R$ 3.220,60. O valor estimado para a comercialização dos peixes foi de R$ 2.477,50. Na análise de viabilidade econômico/financeira os resultados indicam retorno a partir do segundo ciclo produtivo. Na dimensão social se destaca a mão de obra familiar ocupada e cuja maior demanda é no período de implementação, enquanto na manutenção é baixa esta necessidade. Na análise ambiental os resultados indicaram a preservação de recursos naturais, com reaproveitamento de resíduos de alimentos produzidos na propriedade e cuidados com a água e geração de efluentes.