bluuebunny/crossref_metadata_2025_split huggingface dataset:
Surgical repair of incarcerated umbilical hernia in a white German Spitz
Authors: Munif Mohammad Raguib , Masud Rony Ibne , Tasnim Shadia 
Published: April 2024

Abstract
Background
An umbilical hernia is common, but its incarcerated form is quite rare in dogs. An incarcerated hernia is characterized by the entrapment of herniated contents within the hernial sac, often accompanied by a constricted or narrower ring. It is usually refractory to the conservative approach, i.e., manual reduction, and surgical treatment is crucial to avert the risk of ischemia that can potentially lead to necrosis and gangrene in the involved tissues.

Case presentation
A 7-month-old female white German Spitz of 13.22 kg was presented with an ovoid swelling in the umbilicus, including a history of intermittent vomiting, progressive hyporexia, and weakness. Physical examinations led to a presumptive diagnosis of irreducible umbilical hernia after ultrasonography had shown a defect in abdominal wall continuity. Surgical intervention further confirmed an umbilical hernia with the incarceration of an omental flap. Herniorrhaphy was performed after resolving the incarceration and returning the content (i.e., omental flap) to the abdominal cavity. Postoperatively, supportive medications and routine care were provided. The external sutures were removed after two weeks, and periodic follow-ups revealed no complications. Ultrasonography was performed again on the 78th postoperative day, which indicated no breach in the abdominal wall integrity around the umbilicus. To the authors’ knowledge, this is the first documented case of a successfully treated incarcerated umbilical hernia in a white German Spitz.

Conclusions
Umbilical hernias in young Spitz dogs can undergo incarceration over time if left untreated during the early stages. Meticulous diagnosis and specific treatment including surgical correction are essential for optimal outcome, avoiding further complications.
Demand and key technology for a LEO constellation as augmentation of satellite navigation systems
Authors: Yang Yuanxi , Mao Yue , Ren Xia , Jia Xiaolin , Sun Bijiao 
Published: April 2024

AbstractA Low Earth Orbit (LEO) constellation augmenting satellite navigation is important in the future development of Global Navigation Satellite System (GNSS). GNSS augmented by LEO constellations can improve not only the accuracy of Positioning, Navigation, and Timing (PNT), but also the consistency and reliability of secure PNT system. This paper mainly analyzes the diverse demands of different PNT users for LEO augmented GNSS, including the precision demand in real-time, the availability demand in special areas, the navigation signal enhancement demand in complex electromagnetic environments, and the integrity demand with high security. Correspondingly, the possible contributions of LEO constellations to PNT performance are analyzed from multiple aspects. A particular attention is paid to the special PNT user requirements that cannot be fulfilled with existing GNSS, such as the PNT service demand in the polar regions and the onboard GNSS orbit determination demand of some LEO satellites. The key technologies to be considered in the constellation design, function realization, and payload development of the LEO-augmented navigation system are summarized.
Prognostic factors in patients with heart failure and sarcopenia: an observational retrospective study
Authors: Imamura Yasutaka , Suzuki Atsushi , Kamishima Kazuho , Suzuki Kazuhito , Yamaguchi Junichi 
Published: April 2024

Abstract
Background
Heart failure (HF) prevalence increases with age, and sarcopenia is a poor prognostic factor in patients with HF. We aimed to evaluate the characteristics and prognostic factors in patients with HF and sarcopenia.

Results
We retrospectively reviewed 256 consecutive patients admitted to our hospital for HF between May 2018 and May 2021, underwent dual-energy X-ray absorptiometry, and were diagnosed with sarcopenia. The primary endpoint was all-cause mortality. The prognoses and characteristics were evaluated and compared between patients with left ventricular ejection fraction (LVEF) < 50% (reduced LVEF, HF with reduced ejection fraction [HFrEF]) and those with LVEF ≥ 50% (preserved LVEF, HF with preserved ejection fraction [HFpEF]). 83 (32%) and 173 (68%) patients had HFrEF and HFpEF, respectively. The HFrEF group had fewer women, lower hypertension rates, higher ischemic heart disease rates, and brain natriuretic peptide (BNP) levels than did the HFpEF group. Kaplan–Meier analysis for all-cause death showed that the HFrEF group had a significantly worse prognosis than the HFpEF group [log-rank p = 0.002].

Conclusions
In patients with HF and sarcopenia, older age, higher New York Heart Association (NYHA) class, BNP levels, and reduced LVEF were independent predictors of death after evaluation. During the treatment of patients with HF and sarcopenia, it is necessary to manage treatment with close attention to BNP and LVEF.
Right iliopsoas kaposiform hemangioendothelioma: a case report
Authors: Ren Neng , Gu Ye , Song Na , Qian Wen , Gao Wenhui , Zhang Yunfeng 
Published: April 2024

Abstract
Background
Kaposiform hemangioendothelioma (KHE) is a rare neoplasm of vascular origin. It may involve skin, bone, connective tissue, and parenchymal organs, and it is difficult to make a definite diagnosis in the early stage because Kasabach-Merritt phenomenon may occur in some cases.

Case presentation
On June 12, 2022, a 19-month boy was admitted to our department with the chief complaint of flexion of the right hip joint for over 1 year. An exploratory laparotomy and pelvic lesion resection were conducted and the resection of the iliopsoas muscle mass was performed. The intraoperative resection of the neoplasm confirmed the pathological diagnosis of kaposiform hemangioendothelioma. The vital signs of the child were stable and recovered well after surgery, and the platelet and coagulation indices were normal.

Conclusion
KHE is a rare disease in clinics, the number of confirmed cases in the world is still relatively few, and the etiology and mechanism of the disease are still unknown, which could result in misdiagnose and delayed treatment in the disease early stages. It is necessary to continue to collect relevant cases, to unify the standard treatment guidelines as soon as possible, to reduce the mortality rate, and to improve the quality of life of the cases.
Low-dose versus standard-dose normal temporal bone CT in children: a comparison study
Authors: Rashma R. , Kumar Jyoti , Garg Anju , Batra Radhika , Meher Ravi , Phulia Ankita 
Published: April 2024

Abstract
Objective
To compare the image quality of normal anatomical structures and radiation dose on low-dose (LDCT) and standard-dose (SDCT) temporal bone CT in children.

Methods
The study included 45 LDCT (80 kV and 130 mAs) and 45 SDCT (120 kV and 170 mAs) scans in children, 1–15 years of age. LDCT and SDCT scans were analyzed on H60s and H70h reconstruction kernels, respectively. Two readers assessed the image quality for 25 anatomical structures, using a 5-point scale. A score of 3 and above was considered “sufficient” and 2 and below was considered “insufficient” image quality. Image noise, contrast, age and size-specific effective doses were calculated.

Results
Despite an increase in image noise on LDCT, image quality remained sufficient for most structures owing to increased image contrast. The median effective dose on LDCT, calculated with age-specific conversion factor, decreased by 72.9% and that calculated with size-specific conversion factor decreased by 81.8% compared to the dose on SDCT.

Conclusion
LDCT provides comparable image quality for evaluation of temporal bone with significant reduction in radiation dose in children.
Central auditory functions in post-COVID-19 adults; a case control study
Authors: Hewala Sara Hamdy , Kolkaila Enaas Ahmad , Emara Afaf Ahmed , Nada Nashwa 
Published: April 2024

Abstract
Background
This study aimed to evaluate the central auditory abilities in post-coronavirus disease 2019 (COVID-19) adults by using Central Auditory Tests (CATs). This study included a complaining group (GI), a non-complaining group (GII), and a control healthy group (GIII). All subjects were evaluated using CATs

Results
Results demonstrated statistically significant differences across groups as regards Speech Perception in Noise Test (SPIN), Duration Pattern Sequence Test (DPT), Gap in Noise Test (GIN), and Memory Test (ANOVA, p-value ≤ 0.05). The post-hoc test revealed that, except for recognition memory, both study groups showed statistically significant differences from the control group. Also, significant differences were detected between both GI and GII groups regarding SPIN−10 signal-to-noise ratio (S/N), DPT, GIN threshold, memory for content, and memory for sequence

Conclusions
COVID-19 led to central auditory processing disorders (c)APD.
Epidemiological features of depression and anxiety among homeless adults with healthcare access problems in London, UK: descriptive cross-sectional analysis
Authors: Rathod Sujit D. , Annand P. J. , Hosseini Paniz , Guise Andrew , Platt Lucy 
Published: April 2024

BackgroundIn England in 2021, an estimated 274 000 people were homeless on a given night. It has long been recognised that physical and mental health of people who are homeless is poorer than for people who are housed. There are few peer-reviewed studies to inform health and social care for depression or anxiety among homeless adults in this setting.AimsTo measure the symptoms of depression and anxiety among adults who are homeless and who have difficulty accessing healthcare, and to describe distribution of symptoms across sociodemographic, social vulnerability and health-related characteristics.MethodWe completed structured questionnaires with 311 adults who were homeless and who had difficulty accessing healthcare in London, UK, between August and December 2021. We measured anxiety and depression symptoms using the 4-item Patient Health Questionnaire (PHQ-4) score. We compared median PHQ-4 scores across strata of the sociodemographic, social vulnerability and health-related characteristics, and tested for associations using the Kruskal–Wallis test.ResultsThe median PHQ-4 score was 8 out of 12, and 40.2% had scores suggesting high clinical need. Although PHQ-4 scores were consistently high across a range of socioeconomic, social vulnerability and health-related characteristics, they were positively associated with: young age; food insecurity; recent and historic abuse; joint, bone or muscle problems; and frequency of marijuana use. The most common (60%) barrier to accessing healthcare related to transportation.ConclusionsAdults who are homeless and have difficulty accessing healthcare have high levels of depression and anxiety symptoms. Our findings support consideration of population-level, multisectoral intervention.
Pediatric Congenital Anterior Skull Base Encephaloceles and Surgical Management: A Comparative Review of 22 Patients Treated Transnasally, Transcranially, or Combined Approach With a Review of the Literature
Authors: Kameda-Smith Michelle M. , Jung Youngkyung , D'Arco Felice , Hewitt Richard , Aquilina Kristian , Jeelani Noor ul Owase 
Published: April 2024

BACKGROUND AND OBJECTIVES:
Anterior basal encephaloceles are considered a rare entity and are often associated with midline cerebral abnormalities. Those with a large skull base defect and herniation of brain parenchyma in the neonate or young infant present unique challenges for surgical management.

METHODS:
We analyzed the neurosurgical administrative and operative databases between 1986 and 2022 to determine clinical presentation, operative approach, and outcome of basal encephaloceles.

RESULTS:
Over the 36-year period, 27 pediatric anterior basal encephaloceles were managed, of which 22 had full documentation and images allowing comprehensive review. Mean age at presentation was 5 years (SD 4.94). The majority were transethmoidal encephaloceles (59%), followed by the transsphenoidal-sphenoethmoidal type (32%). Overall, 91% were managed surgically by a transcranial, endoscopic, or combined approach. Four children required subsequent procedures, predominantly for persistent cerebrospinal fluid leak. No significant differences in proportion of patients requiring interval/revision surgery after initial conservative, endoscopic endonasal, or transcranial surgery was identified. Neither age at surgery nor size of the defect on computed tomography scan was associated with the need for revision surgery. Size of cranial defect was significantly smaller in the endoscopic group (P = .01). There was a historic tendency for younger children with larger defects to have a transcranial approach. With the addition of endoscopic skull base expertise, smaller defects in older children were more recently treated endoscopically.

CONCLUSION:
Basal encephaloceles are rare and complex lesions and are optimally managed within a skull base multidisciplinary team able to provide multiple approaches. Large skull base defects with brain parenchymal involvement often require a transcranial or combined transcranial–endoscopic approach.
Angiographic Evolution of Brain Arteriovenous Malformation Angioarchitecture After Partial Endovascular Treatment
Authors: Quarta Colosso Giulio , Aubertin Mathilde , Rius Emily , Guerra Xavier , Burel Julien , Mathon Bertrand , Nouet Aurélien , Premat Kevin , Drir Mehdi , Allard Julien , Lenck Stéphanie , Sourour Nader-Antoine , Clarençon Frédéric , Shotar Eimad 
Published: April 2024

BACKGROUND AND OBJECTIVES:
Endovascular embolization of brain arteriovenous malformations (AVMs) is sometimes intentionally partial, in the case of staged treatment for instance. Residual AVMs may be prone to angioarchitectural modification during follow-up. The objective of this work is to evaluate the nature and extent of these modifications.

METHODS:
We performed a retrospective monocentric study on a cohort of adult patients treated by incomplete endovascular embolization for ruptured and unruptured AVMs with an available angiographic follow-up, without any intervening confounding event between the 2 angiographic examinations. AVM angioarchitectural modifications (arterial, nidal, and venous) were analyzed. Clinical and radiological data were tested in univariate analyses for association with the occurrence of AVM regression or progression.

RESULTS:
Eighty-two partial embolization sessions in 57 patients were included in the study. A 40% (33/82) rate of modification was found on follow-up, with 23/82 (28%) controls showing at least one angioarchitectural regression feature and 15/82 (18.3%) showing at least one angioarchitectural progression item. Nidal growth was the most frequent modification occurring after 12/82 (14.6%) embolizations. The only factor associated with nidal volume growth was a longer time interval between embolization and follow-up (median [IQR]: 190 [250] days vs 89.5[133] days in the subgroup without nidal growth; P = .02). Specific modifications of arterial supply, nidal anatomy, and venous drainage were identified and documented.

CONCLUSION:
Angioarchitectural modifications (both progression and regression) of brain AVMs are frequent findings after partial embolization. Nidal volume growth is associated with longer time intervals between embolization and follow-up.
External Validation of the Modified Southwestern Aneurysm Severity Index in the Barrow Ruptured Aneurysm Trial Surgical Cohort
Authors: Labib Mohamed A. , Catapano Joshua S. , Inoue Mizuho , Kupanoff Kristina M. , Singh Rohin , Abramov Irakliy , Scherschinski Lea , Srinivasan Visish M. , Youn Teddy S. , Spetzler Robert F. , Lawton Michael T. 
Published: April 2024

BACKGROUND AND OBJECTIVES:
Predicting functional outcomes after surgical management of ruptured aneurysms is essential. This study sought to validate the modified Southwestern Aneurysm Severity Index (mSASI), which predicts functional outcomes 1 year after treatment.

METHODS:
The surgical arm of a randomized controlled trial, the Barrow Ruptured Aneurysm Trial, was used to validate the mSASI model. mSASI scores incorporating the Hunt and Hess scale, Non-Neurological American Society of Anesthesiologists Physical Classification Status, imaging findings, and other modifiers were assigned and evaluated against the Glasgow Outcome Scale (GOS) score at 1 year. The model's performance was assessed for discrimination and calibration. Similar evaluations were constructed using the modified Rankin Scale (mRS) as the 1-year functional outcome measurement. Long-term outcomes (3, 6, 10 years) were also evaluated.

RESULTS:
Of 280 clinical trial patients treated surgically, 242 met the inclusion criteria. The mean age was 54.1 ± 12.9 years; 31% were men. Favorable GOS score (4-5) and mRS score (0-2) at 1 year were observed in 73.6% and 66.1% of patients, respectively. The mSASI model predicted unfavorable GOS score at 1 year with fair to good discrimination (area under the curve = 0.75, 95% CI = 0.68-0.82) and accurate calibration (R2 = 0.98). Similar results were obtained when mRS was used as the outcome measure (area under the curve = 0.75, 95% CI = 0.68-0.82; R2 = 0.95).

CONCLUSION:
The mSASI model was externally validated in our cohort to predict functional outcomes using the GOS or mRS scores 1 year after surgery. This index may be used for prognosticating outcomes of patients undergoing surgery for ruptured aneurysms at short-term and long-term intervals.
Extent of Resection Thresholds in Molecular Subgroups of Newly Diagnosed Isocitrate Dehydrogenase–Wildtype Glioblastoma
Authors: Dono Antonio , Zhu Ping , Takayasu Takeshi , Arevalo Octavio , Riascos Roy , Tandon Nitin , Ballester Leomar Y. , Esquenazi Yoshua 
Published: April 2024

BACKGROUND AND OBJECTIVES:
Maximizing the extent of resection (EOR) improves outcomes in glioblastoma (GBM). However, previous GBM studies have not addressed the EOR impact in molecular subgroups beyond IDH1/IDH2 status. In the current article, we evaluate whether EOR confers a benefit in all GBM subtypes or only in particular molecular subgroups.

METHODS:
A retrospective cohort of newly diagnosed GBM isocitrate dehydrogenase (IDH)–wildtype undergoing resection were prospectively included in a database (n = 138). EOR and residual tumor volume (RTV) were quantified with semiautomated software. Formalin-fixed paraffin-embedded tumor tissues were analyzed by targeted next-generation sequencing. The association between recurrent genomic alterations and EOR/RTV was evaluated using a recursive partitioning analysis to identify thresholds of EOR or RTV that may predict survival. The Kaplan–Meier methods and multivariable Cox proportional hazards regression methods were applied for survival analysis.

RESULTS:
Patients with EOR ≥88% experienced 44% prolonged overall survival (OS) in multivariable analysis (hazard ratio: 0.56, P = .030). Patients with alterations in the TP53 pathway and EOR <89% showed reduced OS compared to TP53 pathway altered patients with EOR>89% (10.5 vs 18.8 months; HR: 2.78, P = .013); however, EOR/RTV was not associated with OS in patients without alterations in the TP53 pathway. Meanwhile, in all patients with EOR <88%, PTEN-altered had significantly worse OS than PTEN-wildtype (9.5 vs 15.4 months; HR: 4.53, P < .001).

CONCLUSION:
Our results suggest that a subset of molecularly defined GBM IDH-wildtype may benefit more from aggressive resections. Re-resections to optimize EOR might be beneficial in a subset of molecularly defined GBMs. Molecular alterations should be taken into consideration for surgical treatment decisions in GBM IDH-wildtype.
Direct V3 Vertebral Artery Access for Embolization of Partially Thrombosed Fusiform Basilar Trunk Aneurysm: Technical Case Instruction
Authors: Nguyen Vincent N. , Demetriou Alexandra N. , Dallas Jonathan , Lin Michelle , Fujii Tatsuhiro , Gogia Angad S. , Rennert Robert C. , Atai Nadia A. , Abedi Aidin , Russin Jonathan J. , Mack William J. 
Published: April 2024

BACKGROUND AND IMPORTANCE:
Fusiform vertebrobasilar aneurysms carry significant morbidity. Endovascular strategies are preferred; however, unsafe or unfeasible access can call for innovative strategies.

CLINICAL PRESENTATION:
An octogenarian patient with an enlarging fusiform proximal basilar artery aneurysm causing a sixth nerve palsy was found to have multiple anatomic features that precluded a transradial or transfemoral endovascular approach. She was thus treated with direct microsurgical access of the V3 segment of the vertebral artery for subsequent coil embolization and flow diversion.

CONCLUSION:
This case introduces a novel combined microsurgical and endovascular strategy for treating a complex partially thrombosed fusiform basilar artery aneurysm. This approach should be reserved only for patients where conventional endovascular access is dangerous or unfeasible.
Arf GTPase-Activating proteins ADAP1 and ARAP1 regulate incorporation of CD63 in multivesicular bodies
Authors: Suzuki Kasumi , Okawa Yoshitaka , Akter Sharmin , Ito Haruki , Shiba Yoko 
Published: April 2024

ABSTRACT
Arf GTPase-activating proteins (ArfGAPs) mediate the hydrolysis of GTP bound to ADP-ribosylation factors. ArfGAPs are critical for cargo sorting in the Golgi-to-ER traffic. However, the role of ArfGAPs in sorting into intralumenal vesicles (ILVs) in multivesicular bodies (MVBs) in post-Golgi traffic remains unclear. Exosomes are extracellular vesicles (EVs) of endosomal origin. CD63 is an EV marker. CD63 is enriched ILVs in MVBs of cells. However, the secretion of CD63 positive EVs has not been consistent with the data on CD63 localization in MVBs, and how CD63-containing EVs are formed is yet to be understood. To elucidate the mechanism of CD63 transport to ILVs, we focused on CD63 localization in MVBs and searched for the ArfGAPs involved in CD63 localization. We observed that ADAP1 and ARAP1 depletion inhibited CD63 localization to enlarged endosomes after Rab5Q79L overexpression. We tested epidermal growth factor (EGF) and CD9 localization in MVBs. We observed that ADAP1 and ARAP1 depletion inhibited CD9 localization in enlarged endosomes but not EGF. Our results indicate ADAP1 and ARAP1, regulate incorporation of CD63 and CD9, but not EGF, in overlapped and different MVBs. Our work will contribute to distinguish heterogenous ILVs and exosomes by ArfGAPs.
Uremic pericarditis: a case report of favorable outcomes with early detection and management
Authors: Davalos Jesus , Sullivan Sierra , McCool Hannah , Fenner Blayne , Islam Ebtesam 
Published: April 2024

Uremic pericarditis is a rare, potentially life-threatening complication of end-stage renal disease (ESRD) caused by the accumulation of uremic toxins. This case report describes a 32-year-old man with diabetes and ESRD on hemodialysis who developed uremic pericarditis. The patient presented with fever, chest pain, dyspnea, cough, and foot pain. Diagnostic investigations led to treatment with broad-spectrum antibiotics and surgical debridement of a necrotizing soft tissue infection of the right foot. The lack of clinical improvement in hemodynamic status prompted rapid investigation with electrocardiography and echocardiography, confirming the diagnosis of uremic pericarditis. Prompt initiation of renal replacement therapy with close monitoring led to a successful management outcome. This case report highlights the importance of early recognition, appropriate interventions, and a multidisciplinary approach in treating uremic pericarditis.

Keywords: End-stage renal disease, uremic pericarditis, dialysis-associated pericarditis, pericardial friction rub