bluuebunny/crossref_metadata_2025_split huggingface dataset:
Functional foods in the northwestern Himalayan Region of India and their significance: a healthy dietary tradition of Uttarakhand and Himachal Pradesh
Authors: Dwivedi Sushmita , Singh Vineet , Mahra Kanika , Sharma Kritika , Baunthiyal Mamta , Shin Jae-Ho 
Published: June 2024

AbstractThe Himalayan mountain range in India is home to some of the most diverse ethnic communities and tribes, especially in the northwestern Himalayan range, which spans between the Indian provinces/states of Uttarakhand and Himachal Pradesh. The rich and diversity of the local flora offers nutritional diversity and ensures therapeutic certainty for the local communities (e.g., Garhwali, Kumaoni, Bhotiya, Jaunsari, Gaddi, and Kinnauri). The local varieties of millet, legumes, leafy vegetables, tubers, and ferns in different forms (fresh, sundried, flour, pickled, or fermented) are commonly used to prepare different dishes and locally produced beverages (e.g., soor/sur, pakhoi/paakuyi, chhang, jann/jan, jhol, lugdi/lugri, etc.). This centuries-old indigenous experience, the knowledge of local flora, and the traditional food preparation are key to meeting the dietary demands of local communities. In addition, these local delicacies are also rich in health-benefiting bioactive molecules and have functional food properties, which are not documented yet. Therefore, this review closely examines the functional food properties of the traditional food prepared in the Uttarakhand and Himachal Pradesh regions and provides the scientific evidence to preserve this rich dietary traditions.
Uncovering and evaluating coconut oil-loaded silica nanoemulsion as anti-viral, bacterial, and fungal: synthesis, fabrication, characterization, and biosafety profiles
Authors: Elnosary Mohamed E. , Aboelmagd Hesham A. , Sofy Ahmed R. , Hmed Ahmed A. , Refaey Ehab E. , Ali Sayeda M. , Hady Mayssa Abdel 
Published: June 2024

Abstract
Background
Coconut oil, a natural component abundant in terpenoids, possesses various physiological functions. The global concern over the spread of viral infections and antimicrobial-resistant bacteria and fungi has highlighted the need for novel treatments. Coconut oil, with its known antimicrobial properties, presents an attractive candidate for combating these pathogens. This study aims to investigate the potential of coconut oil-loaded silica nanoemulsion (ON@SiO2) as a novel therapeutic agent against viral, antimicrobial-resistant bacteria, and fungal pathogens.

Results
The study synthesized coconut oil-loaded silica nanoemulsion (ON@SiO2) using an eco-friendly, cost-effective method with native coconut oil (CO). Characterization confirmed successful synthesis on the nanoscale with good distribution. Three nanoemulsion samples (ON-1@SiO2, ON-2@SiO2, and ON-3@SiO2) were prepared, with average particle sizes of 193 nm, 200 nm, and 325 nm, respectively. Evaluation of cytotoxicity on Vero-E6 cell lines indicated safety of ON-0@SiO2 and ON-3@SiO2, with CC50 values of 97.5 mg/ml and 89.1 mg/ml, respectively. ON-3@SiO2 demonstrated anti-Herpes I and II (HSV1 and HSV2) activity, with IC50 values of 1.9 mg/ml and 2.1 mg/ml, respectively. Additionally, ON-3@SiO2 exhibited promising antibacterial activity against E. coli, P. aeruginosa, S. aureus, and B. subtilis, with MIC values of 25 mg/ml, 12.5 mg/ml, 25 mg/ml, and 3.12 mg/ml, respectively.

Conclusions
ON-3@SiO2 showed potential antifungal activity against C. albicans, a unicellular fungus, with an MIC of 12.5 mg/ml. Overall, ON@SiO2 possesses antiviral, antibacterial, and antifungal properties.
The impact of technology readiness and adapting behaviours in the workplace: a mediating effect of career adaptability
Authors: Kumi Ernest , Osei Hannah Vivian , Asumah Sampson , Yeboah Abraham 
Published: June 2024

AbstractThis study aims to explore the impact of technology readiness (TR) on career adaptability (CA) and adapting behaviours among public sector workers in Ghana. It also examines the mediating role of CA in the relationship between TR and adapting behaviours. The study adopts a quantitative research design using a survey method. A sample of 484 public sector employees from various government agencies and departments in Ghana is selected. The study employed a non-probability sampling procedure that combined convenience and purposeful sampling. The data are analysed using covariance-based structural equation modelling with AMOS v24 to test the hypotheses and the proposed conceptual model. The results show that TR has a positive and significant effect on CA, boundary integration, and job crafting. CA also has a positive and significant effect on boundary integration and job crafting. Furthermore, CA mediates the relationship between TR and the two adapting behaviours. This study is one of the first to investigate the influence of TR on CA and adapting behaviours. It reveals how employees respond to the challenges and opportunities of technological innovation and work transformation. It also provides useful insights and recommendations for enhancing technology adoption and career development among public sector workers, especially in developing countries.
Reach and impact of a nationwide media campaign in Ethiopia for promoting safe breastfeeding practices in the context of the COVID-19 pandemic
Authors: Negussie Abel , Tefera Bereket , Mazengia Elyas Melaku , Hailemariam Ariam , Lejore Ephrem , Dejene Tariku , Tefera Abiy , Noor Ramadhani , Chitekwe Stanley , Getachew Hiwot , Sharma Rachana , Girma Eshetu 
Published: June 2024

Abstract
Background
In response to the COVID-19 challenge and the consequent concerns and misconceptions about potential mother-to-child virus transmission, the United Nations Children’s Fund (UNICEF), in collaboration with the Ethiopian Ministry of Health, launched a 3-month nationwide media campaign to promote appropriate and safe breastfeeding practices using national and regional television and radio channels, as well as social media. This study assesses the reach and impact of a media campaign in Ethiopia on improving mothers’, partners’/caregivers’, and the public’s awareness of and practices related to appropriate and safe breastfeeding.

Methods
A two-round mobile survey was conducted using random digit dialing (RDD) and an interactive voice response (IVR) system. In order to assess the impact of the media campaign, the study compared outcomes related to awareness, perceptions, and safe breastfeeding practices using post-intervention comparison data across levels of exposure (exposed vs. unexposed to the campaign). A propensity score matching (PSM) analysis was performed using a two sample test of proportions to estimate the impact of the media campaign.

Results
Among the 3170 mobile subscribers who completed the survey questions, half (50%) reported that they had seen or heard media advertisements about appropriate breastfeeding, the importance of continuing breastfeeding during the COVID-19 pandemic, and how to safely breastfeed a baby when a mother is suspected or confirmed with COVID-19. The PSM analysis showed that exposure to the media campaign was significantly associated with awareness and perceptions of the importance of continuing appropriate breastfeeding during the pandemic among the general public (proportion difference, 0.16; 95% CI, 0.12–0.19; p < 0.0001) and mothers with children under 2 years old or their partners (proportion difference, 0.06; 95% CI, 0.01–0.12, p = 0.01).

Conclusions
The nationwide media campaign promoting safe breastfeeding practices in the context of COVID-19 reached half of the target breastfeeding mothers and the general public and had a significant impact on awareness and perceptions about the importance of continuing appropriate and safe breastfeeding practices. Future media campaigns should ensure that the intensity and frequency of media spots are appropriate to achieve adequate exposure, message recall, and influence infant and young child feeding behaviors.
Krascendo-170 Lung: A phase Ib/II study of divarasib + pembrolizumab ± platinum-based chemotherapy and pemetrexed in untreated KRAS G12C+advanced non-small cell lung cancer (NSCLC).
Authors: Skoulidis Ferdinandos , Cuppens Kristof , Sacher Adrian G. , Velcheti Vamsidhar , Lee Dae Ho , Lin Mark T. , Fernando Tharu M. , Li Shuai , Bradley Denise , Zarak Crnkovic Martina , Mathisen Michael 
Published: June 2024

TPS8651 Background: The KRAS G12C mutation, present in ~12% of NSCLC patients, drives oncogenic signaling and cancer formation and is associated with poor prognosis. The current first-line treatment for advanced KRAS G12C+ NSCLC is checkpoint inhibitor (CPI) ± chemotherapy (CT). Novel combinations using a more targeted, biomarker-directed approach are supported by pre-clinical evidence and may further improve outcomes. Divarasib is an oral KRAS G12C inhibitor with potent pre-clinical and clinical anti-tumor activity. We hypothesize that divarasib + CPI ± CT may improve outcomes for patients with KRAS G12C+ NSCLC. Methods: Krascendo-170 Lung (NCT05789082) is a phase Ib/II, open-label study evaluating the safety and activity of divarasib + pembrolizumab in patients with PD-L1 tumor cell expression ≥1% (Cohort A) and of divarasib + pembrolizumab with platinum-based CT and pemetrexed in patients with any PD-L1 tumor cell expression level (Cohort B). Patients must be ≥18 years old with untreated unresectable/metastatic non-squamous NSCLC (measurable per RECIST v1.1), a confirmed KRASG12C mutation, and an Eastern Cooperative Oncology Group performance status 0/1. Each cohort will have two stages: divarasib combination dose finding and dose expansion, with two planned dose levels of divarasib (Table). Tumor assessments will be performed at baseline and every 6 weeks for 48 weeks, then every 9 weeks thereafter. Plasma samples will be taken at various timepoints before and after divarasib and pembrolizumab dosing to characterize pharmacokinetics. Patients will be treated until disease progression per RECIST v1.1 or unacceptable toxicity. The co-primary endpoints are adverse events and change from baseline in targeted safety parameters. Key secondary endpoints include objective response rate, progression-free survival and duration of response (all investigator assessed per RECIST v1.1). Enrollment into the combination dose finding stage of Cohort A has been completed without dose-limiting toxicities and enrollment into the dose expansion stage is continuing. Clinical trial information: NCT05789082 . [Table: see text]
Improved Oral Health in Adults With X-Linked Hypophosphatemia Treated With Burosumab
Authors: Hervé Agathe , Gadion Margaux , Herrou Julia , Izart Mathieu , Linglart Agnès , Cohen-Solal Martine , Lecoq Anne-Lise , Kamenicky Peter , Briot Karine , Chaussain Catherine , Biosse Duplan Martin 
Published: June 2024

Abstract

Context
X-linked hypophosphatemia (XLH) is a rare genetic bone disease affecting both children and adults, with oral manifestations such as spontaneous dental infections. The main treatments for XLH are conventional treatment (CT) with oral phosphate salts and active vitamin D supplementation and burosumab, an antibody targeting fibroblast growth factor 23. While the beneficial effect of CT on oral manifestations is established, the effect of burosumab on oral health is unknown, especially in adults.

Objective
We aimed to compare the oral health (number of missing or endodontically treated teeth and presence of periodontal disease) and incidence of endodontic infections of adult patients with XLH according to their treatment's modalities (no treatment, CT, or burosumab).

Methods
This was achieved through a single-center, retrospective analysis of oral health data from 44 patients who had undergone dental monitoring for at least 6 months.

Results
Oral health varied according to the proportion of their adult life spent under treatment for XLH, and the incidence of dental infections during follow-up was influenced by the type of treatment received. There was a 55.9% reduction of infections during CT and an 86.4% reduction during burosumab treatment compared to periods with no treatment (P &lt; .0001). Comparing treatment and nontreatment periods within the same patient showed a strong association between burosumab treatment and decreased infection incidence (.006 vs .09 infection per month, P &lt; .01).

Conclusion
We observed that adults with XLH treated with burosumab developed fewer endodontic infections during dental follow-up than patients who were untreated or received CT.
SGIP1 binding to the α-helical H9 domain of cannabinoid receptor 1 promotes axonal surface expression
Authors: Fletcher-Jones Alexandra , Spackman Ellen , Craig Tim J. , Nakamura Yasuko , Wilkinson Kevin A. , Henley Jeremy M. 
Published: June 2024

ABSTRACT
Endocannabinoid signalling mediated by cannabinoid receptor 1 (CB1R, also known as CNR1) is critical for homeostatic neuromodulation of both excitatory and inhibitory synapses. This requires highly polarised axonal surface expression of CB1R, but how this is achieved remains unclear. We previously reported that the α-helical H9 domain in the intracellular C terminus of CB1R contributes to axonal surface expression by an unknown mechanism. Here, we show in rat primary neuronal cultures that the H9 domain binds to the endocytic adaptor protein SGIP1 to promote CB1R expression in the axonal membrane. Overexpression of SGIP1 increases CB1R axonal surface localisation but has no effect on CB1R lacking the H9 domain (CB1RΔH9). Conversely, SGIP1 knockdown reduces axonal surface expression of CB1R but does not affect CB1RΔH9. Furthermore, SGIP1 knockdown diminishes CB1R-mediated inhibition of presynaptic Ca2+ influx in response to neuronal activity. Taken together, these data advance mechanistic understanding of endocannabinoid signalling by demonstrating that SGIP1 interaction with the H9 domain underpins axonal CB1R surface expression to regulate presynaptic responsiveness.
Risk Factors for Recurrence After Surgery for Rectal Cancer in a Modern, Nationwide Population-Based Cohort
Authors: Doroudian Sepehr , Osterman Erik , Glimelius Bengt 
Published: June 2024

Abstract
Background
The success of modern multimodal treatment in rectal cancer is dependent on risk prediction. Better knowledge of the risk of locoregional and distant recurrence, in relation to preoperative treatment, pathological stage, and commonly used risk factors, is needed when deciding on adjuvant therapy and surveillance.

Methods
The Swedish ColoRectal Cancer Registry was used to identify patients diagnosed with rectal adenocarcinoma between 2011 and 2018. Readily available variables, including patient, tumor, and treatment factors were exposures. Cox proportional hazard models were used to identify important risk factors for recurrence and calculate recurrence risks.

Results
A total of 9428 curatively resected patients were included and followed for a median of 72 months. Eighteen percent had distal recurrence and 3% had locoregional recurrence at 5 years. Risk factors with major impact on distal recurrence were pT4a (hazard ratio [HR] 5.1, 95% confidence interval [CI] 3.3–8.0), pN2b (HR 3.4, 95% CI 2.7–4.2), tumor deposit (HR 1.7, 95% CI 1.5–1.9), lymph node yield (HR 1.5, 95% CI 1.3–1.8), and tumor level 0–5 cm (HR 1.5, 95% CI 1.3–1.8). Pathologic stage and number of risk factors identified groups with markedly different recurrence risks in all neoadjuvant treatment groups.

Conclusions
Readily available risk factors, as a complement to stage, are still valid and robust in all neoadjuvant treatment groups. Tumor deposit is important, while circumferential resection margin might no longer be important with improved oncological treatments and high-quality TME surgery. Tailored surveillance is possible in selected groups using risk stratification based on stage and risk factors.
Symptoms and prophylaxis of venous thromboembolism in the population of cancer and hospice patients-what is known?
Authors: Składanek Justyna , Leśkiewicz Michał , Daniel Piotr , Otręba Karina , Cieszkowska Joanna , Czupryńska Karolina 
Published: June 2024

In a group of palliative patients, venous thromboembolism (VTE) is a significant cause of death and reduction in quality of life. Current guidelines and scientific research on thromboprophylaxis most often refer to the population of oncology patients, who differ in many aspects from patients receiving palliative care. Thus, doctors working with patients undergoing palliative treatment have to face many problems related to safety and effectiveness of antithrombotic therapy in this type of care.
In the case of chronically ill patients, diagnostic process may be somewhat difficult because the symptoms resulting from the underlying diseases can mask VTE symptoms. The aim of this article is to review the literature on symptoms and thromboprophylaxis in this group of patients.
According to the latest guidelines of the American Society of Clinical Oncology (ASCO), it is not recommended to use VTE prophylaxis in outpatient oncology patients routinely, but it should be considered in high-risk patients who received a Khorana score of at least 2 before starting a new chemotherapy cycle.
In patients diagnosed with VTE, in long-term prophylaxis lasting at least 6 months, due to greater effectiveness, it is recommended to use low-molecular-weight heparins, edoxaban, rivaroxaban or apixaban instead of vitamin K antagonists, which can be used if the previously mentioned drugs are unavailable. There are some studies which show that thromboprophylaxis may be beneficial for patients in palliative care. On the other hand, another studies’ results suggest that patients won’t gain any benefit from prevention.
As our article shows it is very crucial to conduct scientific research on palliative patients and create clear guidelines for prophylaxis for this group of people.
Assessment of quality of antenatal care services and associated factors in Malawi: Insights from a nationwide household survey
Authors: Mandiwa Chrispin , Namondwe Bernadetta 
Published: June 2024

Introduction
Provision of quality antenatal care (ANC) to pregnant women is essential for reducing maternal and newborn mortality. ANC provides an opportunity for early identification of conditions that increase the risk of adverse pregnancy outcomes. However, there is limited evidence regarding the quality of ANC received by women in Malawi. This study aimed to assess the quality of ANC and associated factors in Malawi.

Materials and methods
National representative data from the 2019–2020 Malawi Multiple Indicator Cluster Survey was used for this cross–sectional study. A total of 6,287 weighted sample of women aged 15 to 49 years who had a live birth and received ANC at least once within two years preceding the survey were included in the analysis. Descriptive statistics were used to estimate the magnitude of quality ANC and multivariable logistic regression was computed to identify associated factors.

Results
Of the 6,287 women, only 12.6% (95% CI: 11.4–13.9) received quality ANC. The likelihood of receiving quality ANC was significantly higher among women who had four to seven ANC contacts (AOR = 2.10; 95% CI: 1.79–2.49), made at least eight ANC contacts (AOR  =  3.40; 95% CI: 1.90–6.09) and started ANC within the first trimester (AOR  =  1.30; 95% CI: 1.10–1.53). On the other hand, women who had only primary education (AOR = 0.62; 95% CI:0.48–0.82) and had five or more births (AOR  =  0.56; 95% CI: 0.40–0.78) were less likely to receive quality ANC.

Conclusion
The findings reveal that quality of ANC in Malawi is low. These findings suggest the need for targeted interventions aimed at improving access to and utilization of ANC services among women with lower education and higher parity. Strengthening efforts to promote early ANC initiation and increasing the number of ANC contacts could significantly enhance the quality of ANC received by women in Malawi.
A surprising property of nonlocal operators: the deregularising effect of nonlocal elements in convolution differential equations
Authors: Goodrich Christopher S. 
Published: June 2024

Abstract
We consider nonlocal differential equations with convolution coefficients of the form

−
M

(

a

*

|
u

|

q

)

(

1

)

μ

(

t

)

u

″

(

t

)

=
λ
f

t
,
u

(

t

)

,
t
∈

(

0,1

)

,

$$-M\left(\left(a {\ast} \vert u{\vert }^{q}\right)\left(1\right)\mu \left(t\right)\right){u}^{{\prime\prime}}\left(t\right)=\lambda f\left(t,u\left(t\right)\right)\text{,\,}t\in \left(0,1\right),$$

where q > 0, subject to given boundary data. The function

μ
∈
C

[

0,1

]

$\mu \in \mathcal{C}\left(\left[0,1\right]\right)$

modulates the strength of the nonlocal element. We demonstrate that the nonlocality has a strong deregularising effect in the specific sense that nonexistence theorems for this problem are directly affected by the magnitude of the function μ. A specific example illustrates the application of the nonexistence results presented herein.
Non-oscillation of linear differential equations with coefficients containing powers of natural logarithm
Authors: Šišoláková Jiřina 
Published: June 2024

Abstract
We study linear differential equations whose coefficients consist of products of powers of natural logarithm and general continuous functions. We derive conditions that guarantee the non-oscillation of all non-trivial solutions of the treated type of equations. The conditions are formulated as a non-oscillation criterion, which is the counterpart of a previously obtained oscillation theorem. Therefore, from the presented main result, it follows that the analysed equations are conditionally oscillatory. The used method is based on averaging techniques for the combination of the generalized adapted Prüfer angle and the modified Riccati transformation. This article is finished by new corollaries and examples.
Hydrodeoxygenation of Anisole via Cu supported on Zeolite: HZSM-5, MOR, and Indonesian Activated Natural Zeolite
Authors: Nugrahaningtyas Khoirina , Sabiilagusti Aji Indo , Rahmawati Fitria , Heraldy Eddy , Hidayat Yuniawan 
Published: June 2024

The conversion of biomass waste into an alternative energy source requires effective and efficient hydrodeoxygenation (HDO) catalysts. This research aimed to synthesize a bifunctional zeolite-based catalyst for anisole conversion into BTX. The noble metal Cu was impregnated on HZSM-5, mordenite, and Indonesian activated natural zeolite (ANZ) to form HDO catalysts. X-ray fluorescence (XRF), X-ray diffraction (XRD), surface area and pore profile analysis, Fourier transform infrared analysis, ammonia-temperature programmed desorption (NH3-TPD), pyridine gravimetry, morphology, and scanning electron microscopy-energy dispersion elemental mapping (SEM-EDX) were used to determine the catalyst's properties. The HDO reaction test used anisole as a model compound in a semi-flow reactor with hydrogen gas at 350 and 500 °C for 1 h. Copper nanocrystals were found on the surface of the zeolites in several metal phase types, including Cu, Cu2O, CuO, and Cu(OH)2. Due to the copper bonds inside the zeolite pores, the internal pore surface area decreased. The acidity also decreased since it is strongly related to the surface area. At 350 °C, Cu was found to be less active. However, at 500 °C, copper activity increased, leading to an increase in anisole conversion and BTX selectivity. The catalyst with the highest anisole conversion and BTX selectivity was Cu/HZSM-5 (i.e., 53.28 and 13.06% v, respectively).