bluuebunny/crossref_metadata_2025_split huggingface dataset:
Determining prognostic indicator for anticoagulant therapy in sepsis-induced disseminated intravascular coagulation
Authors: Iba Toshiaki , Yamakawa Kazuma , Shiko Yuki , Hisamune Ryo , Tanigawa Tomoki , Helms Julie , Levy Jerrold H. 
Published: June 2024

Abstract
Background
There is no reliable indicator that can assess the treatment effect of anticoagulant therapy for sepsis-associated disseminated intravascular coagulation (DIC) in the short term. The aim of this study is to develop and validate a prognostic index identifying 28-day mortality in septic DIC patients treated with antithrombin concentrate after a 3-day treatment.

Methods
The cohort for derivation was established utilizing the dataset from post-marketing surveys, while the cohort for validation was acquired from Japan’s nationwide sepsis registry data. Through univariate and multivariate analyses, variables that were independently associated with 28-day mortality were identified within the derivation cohort. Risk variables were then assigned a weighted score based on the risk prediction function, leading to the development of a composite index. Subsequently, the area under the receiver operating characteristic curve (AUROC). 28-day survival was compared by Kaplan–Meier analysis.

Results
In the derivation cohort, 252 (16.9%) of the 1492 patients deceased within 28 days. Multivariable analysis identified DIC resolution (hazard ratio [HR]: 0.31, 95% confidence interval [CI]: 0.22–0.45, P < 0.0001) and rate of Sequential Organ Failure Assessment (SOFA) score change (HR: 0.42, 95% CI: 0.36–0.50, P < 0.0001) were identified as independent predictors of death. The composite prognostic index (CPI) was constructed as DIC resolution (yes: 1, no: 0) + rate of SOFA score change (Day 0 SOFA score–Day 3 SOFA score/Day 0 SOFA score). When the CPI is higher than 0.19, the patients are judged to survive. Concerning the derivation cohort, AUROC for survival was 0.76. As for the validation cohort, AUROC was 0.71.

Conclusion
CPI can predict the 28-day survival of septic patients with DIC who have undergone antithrombin treatment. It is simple and easy to calculate and will be useful in practice.
Undercommoning Anthrogenesis
Authors: van der Waal Rodante 
Published: June 2024

Abstract
Sophie Lewis coined anthrogenesis as “the production of human beings” and, using this unfamiliar term, calls for the radical reimagining of gestational politics, as an alternative to liberal feminism's focus on choice. Revivisng Shulamith Firestone, for feminists like Lewis and Helen Hester this reimagination takes shape within a techno-utopic communist framework. While enticing, such a framework relies on a modernist understanding of institutions that has been critiqued by decolonial and abolitionist theory and risks undervaluing the fugitive underground work of radical care and mutual aid that already exists today. In this article, two strategies at play in the contemporary Marxist reimagination of anthrogenesis are differentiated: (1) a communist approach focusing primarily on fundamentally restructuring the commons of reproductive care on a grand societal scale and (2) an “undercommons” approach that aims to fugitively abolish public institutions through small-scale mutual aid and radical care practices that are already constituting otherworlds of reproductive justice through transnational coalitions. Highlighting abortion and birth networks in the Netherlands (the Abortion Network Amsterdam and the Geboortebeweging, a loose collaborative network of midwives) who transnationally and fugitively care for anthrogenesis, the second strategy is proposed as the more promising one for the anthrogenesis of human beings otherwise. The author develops another possible outcome of Firestone's revolutionary thought: not a gestational communism but an anarcho-abolitionist fugitive undercommoning of anthrogenesis, through the work Stefano Harney and Fred Moten, Marquis Bey, and Chiara Bottici.
Clinical value of Vitamin-D combined with budesonide/formoterol and theophylline sodium glycinate sustained-release tablets in the treatment of chronic obstructive pulmonary disease patients
Authors: Ni Xiuyuan , Zhou Shigeng , Wang Congling , Chen Shengheng , Hu Jingdan , Zhang Shengjing 
Published: June 2024

Objective: To explore the clinical value of Vitamin-D combined with budesonide/formoterol (BF) and theophylline sodium glycinate (TSG) sustained-release tablets in the treatment of patients with chronic obstructive pulmonary disease (COPD).
Methods: Medical records of 114 patients with CODP, treated in Wenzhou Geriatric Hospital from October 2020 to February 2023, were retrospectively analyzed. Of them, 59 received treatment with Vitamin-D combined with BF and TSG sustained-release tablets (Group-A), and 55 patients received treatment with BF combined with TSG sustained-release tablets (Group-B). Lung function indicators, blood gas status, inflammatory factors, fractional exhaled nitric oxide (FeNO), and 25-hydroxyvitamin D [25(OH)D] levels before and after the treatment in both groups were collected.
Results: After the treatment, lung function indicators, blood gas status, inflammatory factors, FeNO, and 25 (OH) D levels in both groups were significantly improved compared to pretreatment levels, and were significantly better in the Group-A compared to Group-B (P<0.05).
Conclusions: The combination of Vitamin-D, BF, and TSG sustained-release tablets can effectively regulate the blood gas status of patients with COPD, improve lung function, regulate FeNO and 25 (OH) D, and effectively downregulate the levels of inflammatory factors, thus reducing the degree of inflammatory response.
doi: https://doi.org/10.12669/pjms.40.7.9495
How to cite this: Ni X, Zhou S, Wang C, Chen S, Hu J, Zhang S. Clinical value of Vitamin-D combined with budesonide/formoterol and theophylline sodium glycinate sustained-release tablets in the treatment of chronic obstructive pulmonary disease patients. Pak J Med Sci. 2024;40(7):---------. doi: https://doi.org/10.12669/pjms.40.7.9495
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
L'insegnamento intensivo del progetto. Un'esperienza di didattica internazionale
Authors: Mauro Marzo  
Published: June 2024

L'articolo illustra l'esperienza dell'Erasmus Intensive Programme intitolato “Fortified Places” svoltosi in tre edizioni, tra l'aprile del 2012 e il febbraio 2014, a Venezia, Parigi e Siviglia, e indaga il metodo di insegnamento del progetto adottato nell'iniziativa. La discussione sui progetti si è svolta a più livelli incrociati tra loro: studenti-studenti, studenti-docenti, docenti-docenti e questo ha arricchito notevolmente lo scambio di informazioni e metodi didattici intorno al progetto. Svolgendosi in tale modalità, il trasferimento del sapere, dei punti di vista e delle conoscenze è avvenuto sia sull’asse verticale (docente-allievo), sia sull’asse orizzontale (studente-studente, docente-docente).
Editoriale: Campus e città
Authors: FAMagazine Redazione  
Published: June 2024

Il numero 34 di FAmagazine è dedicato al tema del “campus universitario”, tipologia che rientra indubbiamente tra quelle che si sono contraddistinte nella storia moderna del progetto architettonico e nei processi fondativi della città. Strumento “poleogenetico continuamente sperimentato nel corso storico della città e forse oggi, per molteplici aspetti, caricato di ulteriori responsabilità”, il campus universitario è considerato, negli articoli che seguono, nella relazione Università-Città dove, come sostiene Carlo Quintelli, la componente universitaria diventa elemento “strategicamente indispensabile nello sviluppo di un’economia della conoscenza, quella dove la ricerca è alla base di ogni laboratorio produttivo caratterizzato dall’innovazione”. Questo approccio, riscontrabile nel progetto Mastercampus promosso dall’Università di Parma muove a partire da questi presupposti ricavandone due linee di indirizzo, descritte da Quintelli nel suo articolo, in cui in una prima, si considera una strategia “di insediamento universitario applicata all’intera articolazione urbana, tra nucleo storico, prima periferia ed area suburbana” e in una seconda si instaura un “rapporto critico con la città sul piano dimostrativo di fronte a certe sue criticità, presupponendone un effetto di indotto positivo per il contesto”.
“Montage, mon beau souci”
Authors: Elvio Manganaro  
Published: June 2024

Quello che segue è il “resoconto di come gioco e montaggio hanno agito nello specifico di una didattica”. L’autore non parla di gioco e montaggio in termini speculativi. Altri contributi, in questo numero, si dedicano a ciò. Qui si descrivono due esercizi proposti agli studenti del Laboratorio di progettazione architettonica 2 del Politecnico di Milano. Gli esercizi, che sono rivolti a studenti del secondo anno della laurea triennale, hanno come campo di applicazione la città di Venezia. Venezia è sembrata l’unica città in grado di accogliere sperimentazioni di tipo “testuale”. La realtà resta fuori dall’esercizio. Comunque, nel saggio si parla anche di altro: di Gianni Rodari, della Biennale 2019, del numero de «Il Verri» su il montaggio curato da Chiodi e Giglioli e ancora di Mark Fisher e della ineluttabilità al gioco e al montaggio che contraddistingue questi anni; infine di un ritorno al “demone” della geometria.
Riabitare i borghi abbandonati, Nuove strategie abitative contro la crisi pandemica
Authors: Enrico Bascherini  
Published: June 2024

Il distanziamento sociale ha portato alla ribalta il tema di riabitare i borghi abbandonati e le aree interne. Le esperienze nazionali ci raccontano di realtà fatte di comunità, di politiche, di progetti che da anni cercano di dare risposta al tema delle aree interne e dei duemila borghi in stato di semi abbandono. L’attuale situazione pandemica ha accentuato la problematica dei luoghi dispersi e ha acceso i riflettori a questi insediamenti che effettivamente possono diventare una parziale risposta al Covid 19. Oggi bisogna domandarsi se il sistema insediativo del borgo o centro minore può essere una tipologia insediativa che può divenire un modello di vita in condizioni di protezione ovvero un ripiegamento sperimentale, una rivincita bucolica di chi da sempre combatte la metropoli ed il suo stile di vita.
L’elemento verde e l’abitazione nella città in quarantena
Authors: Sara Protasoni  
Published: June 2024

L’articolo affronta la questione della nuova domanda di un rapporto con la natura all’interno e intorno alle nostre case che questi mesi di pandemia hanno rimesso al centro dei comportamenti abitativi. L’obiettivo è quello di ricercare linee di continuità, fratture, radicali trasformazioni e ritorni imprevisti all’interno della cultura disciplinare in relazione alla dialettica tra innovazione e tradizione e intorno alla possibile tenuta del progetto moderno (inteso come fondato sul continuo interrogativo intorno ai propri strumenti e al proprio ruolo sul piano etico e politico) a fronte delle mutate condizioni. Oltre alla decennale ricerca di Luigi Figini nell’ambito della vicenda del Razionalismo Italiano, rilegge il contributo di Pietro Porcinai e l’opera di Leberecht Migge in Germania
Il luogo del ritorno. Principi insediativi della tomba islamica
Authors: Claudia Sansò  
Published: June 2024

Il concetto islamico di Maʿda come «luogo del ritorno» segnala la circolarità del rito musulmano negando una netta separazione tra un ‘rito che accompagna’ e un ‘rito che tramanda’. Nel Dar al Islam il senso del sacro si traduce in forma oltre che attraverso gli edifici delle moschee, — gli spazi più rappresentativi della vita collettiva musulmana — anche mediante un gran numero di tombe/mausolei. Il contributo propone di indagare l’edificazione della Tomba musulmana nel passaggio da rito a forma architettonica fino a desumere il ruolo che la costruzione degli spazi funebri (in particolare i mausolei) riveste nella logica insediativa delle città islamiche, ove spesso gli spazi della vita quotidiana coesistono con gli spazi della morte.
Disegni e progetti, Jo Noero e la pratica architettonica in Sud Africa
Authors: Samanta Bartocci  
Published: June 2024

Opere costruite, progettate, disegnate a mano e ridisegnate postume rispetto alla loro realizzazione, danno vita ad un percorso, ma soprattutto una successione di diversità proprio perché l’architettura non è una disciplina specialistica ma un punto d’incontro tra diverse forme della creatività umana. L’opera professionale di Noeroarchitects (Sud Africa) e le visioni di un repertorio progressivo di disegni di architettura di Jo Noero, tracciano il ruolo del disegno come strumento di raffigurazione non solo dei fatti ma anche dei desideri. Il disegno è per Noero la scrittura comune, il senso del conoscere facendo, proteggendolo dall’astrazione dei diagrammi e dalle figurazioni stilistiche nel suo mestiere di architetto, il disegno ha alimentato la complessità della visione e la rispondente relazione fra l’architettura e la forza dello scopo per cui è costruita.
Dynamic ESG Equilibrium
Authors: Avramov Doron , Lioui Abraham , Liu Yang , Tarelli Andrea 
Published: June 2024

This paper proposes a conditional asset pricing model that integrates environmental, social, and governance (ESG) demand and supply dynamics. Shocks in the demand for sustainable investing represent a novel risk source, characterized by diminishing marginal utility and positive premium. Green assets exhibit positive exposure to ESG demand shocks, hence commanding higher premia. Conversely, time-varying convenience yield leads to lower expected returns for green assets. Moreover, ESG demand shocks have positive contemporaneous effects on unexpected returns, contributing to large positive payoffs in the green-minus-brown portfolio over extended horizons. The model predictions align closely with evidence on return spreads between green and brown assets, further reinforcing the apparent gap between realized and expected spreads. This paper was accepted by Lin William Cong, finance. Funding: Y. Liu acknowledges funding by the Research Grants Council of the Hong Kong Special Administrative Region, China [Grant T35/710/20R]. A. Tarelli acknowledges funding by the European Union - Next Generation EU [Project Code 2022FWZ2CR]. The views and opinions expressed are only those of the authors. Supplemental Material: The online appendices and data files are available at https://doi.org/10.1287/mnsc.2022.03491 .
A Faculty Personal Tutor Model to Support Student Transition into Higher Education During a Global Pandemic
Authors: Broadbent Rebecca , Knight Gillian 
Published: June 2024

Abstract
In 2020, Science, Technology, Engineering and Math (STEM) faculty within a United Kingdom university implemented an online personal tutoring model. This model aimed to deliver a consistent experience to ∼1000 students, supporting learning and fostering a sense of belonging during a global pandemic. Here we describe and evaluate a Curriculum Integrated personal tutor model, designed to provide a structured and dialogic student experience. We provide details on the timetabled activities, aligned to student development needs, and reflect on the model’s effectiveness in supporting student learning, building belonging, and providing accessible delivery. We highlight strengths and explore weaknesses, providing recommendations for implementation of this type of model at other institutions.
Influencing factors of stroke in patients with type 2 diabetes: A systematic review and meta-analysis
Authors: Zhao Mengjiao , Dong Yongze , Chen Luchen , Shen Huajuan 
Published: June 2024

Background
Stroke stands as a significant macrovascular complication among individuals with Type 2 diabetes mellitus (T2DM), often resulting in the primary cause of mortality and disability within this patient demographic. Presently, numerous studies have been conducted to investigate the underlying causes of stroke in individuals with T2DM, yet the findings exhibit inconsistencies.

Objective
This paper aims to consolidate and summarize the available evidence concerning the influential factors contributing to stroke among patients diagnosed with T2DM.

Methods
We conducted a comprehensive search across multiple databases, including Cochrane Library, PubMed, Web Of Science, Embase, China Biology Medicine (CBM), China National Knowledge Infrastructure (CNKI), Wanfang and Weipu up to August 2023. Google Scholar was also searched to retrieve gray literature. We calculated odds ratios (OR) and 95% confidence intervals (CI) using Stata software.

Results
Our analysis encompassed 43 observational studies, exploring factors across sociodemographic, biochemical, complications, and hypoglycemic agent categories. The findings identified several risk factors for stroke in patients with T2DM: age, gender, T2DM duration, hypertension, body-mass index (BMI), smoking, Glycated hemoglobin (HbA1c), estimated Glomerular Filtration Rate (eGFR), albuminuria, Triglycerides (TG), Low density lipoprotein cholesterol (LDL-C), Coronary heart disease (CHD), Atrial fibrillation (AF), diabetic retinopathy (DR), Peripheral vascular disease (PVD), and carotid plaque. Conversely, exercise, High density lipoprotein cholesterol (HDL-C), metformin (MET), pioglitazone, and metformin combination therapy emerged as protective factors.

Conclusion
This study underscores the multitude of influencing factors contributing to stroke in people with T2DM patients, among which the microvascular complications of T2DM play an most important role. Therefore, we emphasize the importance of screening for microvascular complications in patients with T2DM. However, due to limitations arising from the number of articles reviewed, there remain areas where clarity is lacking. Further research efforts are warranted to expand upon and reinforce our current findings.
3D-QSAR, molecular docking, ADMET, simulation dynamic, and retrosynthesis studies on new styrylquinolines derivatives against breast cancer
Authors: EL-Mernissi Reda , Alaqarbeh Marwa , Khaldan Ayoub , Kara Mohammed , Al kamaly Omkulthom , Alnakhli Anwar M. , Lakhlifi Tahar , Sbai Abdelouahid , Ajana Mohammed Aziz , Bouachrine Mohammed 
Published: June 2024

Abstract
Breast cancer is the most common illness among women, accounting for 25% of all diagnoses, as stated by the American Cancer Society. Current research focuses on 43 compounds of styrylquinoline derivatives as potential inhibitors of tubulin to design a new drug that could potentially be effective against breast cancer cells in humans. The target compounds were subjected to a three-dimensional quantitative structure-activity relationship/comparative molecular similarity indices analysis (CoMSIA) approach, where CoMSIA models were used; the best results obtained are (Q
2 = 0.84, R
2 = 0.97,

r

ext

2

{r}_{\text{ext}}^{2}

= 0.91), H-bond acceptor field was discovered to be important for increasing inhibitory activity by examining the contour maps (54%), and it plays a key role in the prediction of anticancer activity. Based on the contour maps of the CoMSIA models, we obtained information that allows us to propose four new molecules with higher cancer inhibitory than the 43 compounds found in the literature. The molecular docking was applied to determine the likely types of binding between the tubulin protein (PDB ID: 4O2B) and the proposed compounds, and the results show that M1 has a higher total score of 6.53 and two interactions with important conventional hydrogen bond type, followed by compound M2 with a total score of 5.74. Furthermore, the designed molecules showed better pharmacokinetic properties based on absorption, distribution, metabolism, excretion, and toxicity properties. Molecular dynamics simulations at 100 ns were conducted to confirm the binding stability of the selected ligands (M1 and M2) with tubulin protein. The simulation parameters used in the current study are root mean square deviation, root mean square fluctuation, H-bond, Rg, solvent accessible surface area, and binding energy. As a result, the designed compounds (ligands M1 and M2) have shown noteworthy potential as a drug candidate for experimental in vivo and in vitro testing due to their potential inhibition of breast cancer. Finally, the study of retrosynthesis in this work facilitates the synthesis of drug candidates.
‘Little Arabia’ on Buddhist land: Exploring the linguistic landscape of Bangkok’s ‘Soi Arab’ enclave
Authors: Gu Chonglong , Bhatt Ibrar 
Published: June 2024

Abstract
Never formally colonised by Western powers, Thailand is a rapidly developing nation in Southeast Asia. To outsiders, the assumption might be that Thailand is a homogenous Thai-speaking Buddhist country. However, such over-simplistic views ignore diversity and the existence of de facto multilingualism and multiculturalism on the ground. This linguistic landscape (LL) study explores a unique and sociolinguistically compelling area called ‘Little Arabia’ (Soi Arab) in the heart of Bangkok, where elements of both Islamic and Buddhist civilisations meet. The existence of this Middle Eastern enclave creates a sense of contrasts on linguistic, religious, and cultural levels. Because of globalisation and spurred by (medical and sex) tourism, this area boasts a number of halal restaurants, hotels, travel agencies, stores, pharmacies, and clinics. This gives rise to an interesting sociolinguistic ecology, featuring an ‘ethnic’ economy which caters to the needs of tourists and businessmen hailing from the Arab world. Drawing on authentic photographic data, this study explores how various linguistic practices give the area a unique identity. More specifically, we reveal how various languages (including Arabic, Thai, and English) are mobilised and combined in ways that illustrate translation practices evidenced within the enclave for particularised marketing, commercial, and communication purposes. Theoretically and conceptually, the term ‘machine-translated multilingualism’ is coined to capture the growing trend for businesses to resort to translation software for multilingual communication, which may result in non-standard translations and orthographic forms. This study contributes to a growing body of sociolinguistic research examining LLs in global cities and commercial hubs in the Global South, particularly those arising from ‘South-South’ population flows.
Die Angst des Schiris vor dem VAR
Authors: Nell Charlotte , Lindner Diana , Rosa Hartmut 
Published: June 2024

Zusammenfassung
Der Artikel untersucht aus phänomenologisch informierter soziologischer Perspektive den Einsatz des VAR im deutschen Fußball. Hermann Schmitz neuphänomenologische Unterscheidung von ‚Konstellation‘ und ‚Situation‘ dient hierzu als sensibilisierende Leitheuristik. Vor dem Hintergrund der vielstimmigen Kritik an dem uneingelösten Gerechtigkeitsversprechen analysieren wir zunächst die Aufgaben der Feldschiedsrichterin unter dem Blickwinkel eines sozialtheoretisch modellierten Idealtypus des ‚hermeneutischen Dirigenten‘. Das Fußballspiel wird hierdurch als ein vielschichtiges situatives Geschehen betrachtet, bei dem die Feldschiedsrichterin eine Vielzahl an Aufgaben erfüllen, aber auch mit blinden Flecken ihrer Urteilskraft umgehen muss. Demgegenüber konstruieren wir den VAR als einen ‚parametrischen Accountant‘, der den Fußball – phänomenologisch betrachtet – von einer Situation in eine Konstellation verwandelt und damit zu einer Überbetonung einseitiger Regelbefolgung führt und den Entscheidungsprozess darüber in eine Black Box verwandelt. Damit trägt er zur Entstehung ,strukturierter Verantwortungslosigkeit‘ auf dem Spielfeld bei.