bluuebunny/crossref_metadata_2025_split huggingface dataset:
Targeting cardiomyocyte cell cycle regulation in heart failure
Authors: Zhu Chaonan , Yuan Ting , Krishnan Jaya 
Published: April 2024

AbstractHeart failure continues to be a significant global health concern, causing substantial morbidity and mortality. The limited ability of the adult heart to regenerate has posed challenges in finding effective treatments for cardiac pathologies. While various medications and surgical interventions have been used to improve cardiac function, they are not able to address the extensive loss of functioning cardiomyocytes that occurs during cardiac injury. As a result, there is growing interest in understanding how the cell cycle is regulated and exploring the potential for stimulating cardiomyocyte proliferation as a means of promoting heart regeneration. This review aims to provide an overview of current knowledge on cell cycle regulation and mechanisms underlying cardiomyocyte proliferation in cases of heart failure, while also highlighting established and novel therapeutic strategies targeting this area for treatment purposes.
Increasing tree cover and high-albedo surfaces reduces heat-related ER visits in Los Angeles, CA
Authors: Sheridan Scott , de Guzman Edith B. , Eisenman David P. , Sailor David J. , Parfrey Jonathan , Kalkstein Laurence S. 
Published: April 2024

AbstractThere is an urgent need for strategies to reduce the negative impacts of a warming climate on human health. Cooling urban neighborhoods by planting trees and vegetation and increasing albedo of roofs, pavements, and walls can mitigate urban heat. We used synoptic climatology to examine how different tree cover and albedo scenarios would affect heat-related morbidity in Los Angeles, CA, USA, as measured by emergency room (ER) visits. We classified daily meteorological data for historical summer heat events into discrete air mass types. We analyzed those classifications against historical ER visit data to determine both heat-related and excess morbidity. We used the Weather Research and Forecasting model to examine the impacts of varied tree cover and albedo scenarios on meteorological outcomes and used these results with standardized morbidity data algorithms to estimate potential reductions in ER visits. We tested three urban modification scenarios of low, medium, and high increases of tree cover and albedo and compared these against baseline conditions. We found that avoiding 25% to 50% of ER visits during heat events would be a common outcome if the urban environment had more tree cover and higher albedo, with the greatest benefits occurring under heat events that are moderate and those that are particularly hot and dry. We conducted these analyses at the county level and compared results to a heat-vulnerable, working-class Los Angeles community with a high concentration of people of color, and found that reductions in the rate of ER visits would be even greater at the community level compared to the county.
Application of Sentinel-1 InSAR to monitor tailings dams and predict geotechnical instability: practical considerations based on case study insights
Authors: Rana Nahyan M. , Delaney Keith B. , Evans Stephen G. , Deane Evan , Small Andy , Adria Daniel A. M. , McDougall Scott , Ghahramani Negar , Take W. Andy 
Published: April 2024

AbstractTailings storage facilities (TSFs) impound mining waste behind dams to ensure public safety, but failure incidents have prompted calls for more robust monitoring programs. Satellite-based interferometric synthetic aperture radar (InSAR) has grown in popularity due to its ability to remotely detect millimeter-scale displacements in most urban and some natural terrains. However, there remains a limited understanding of whether InSAR can be as accurate or representative as on-the-ground instruments, whether failures can be predicted in advance using InSAR, and what variables govern the quality and reliability of InSAR results. To address these gaps, we analyze open-source, medium-resolution Sentinel-1 data to undertake a ground-truth assessment at a test site and a forensic analysis of five failure cases. We use a commercial software with an automated Persistent Scatterer (PS) workflow (SARScape Analytics) for all case study sites except one and a proprietary algorithm (SqueeSAR) with a dual PS and Distributed Scatterer (DS) algorithm for the ground-truth site and one forensic case. The main goal is to deliver practical insights regarding the influence of algorithm/satellite selection, environmental conditions, site activity, coherence thresholds, satellite-dam geometry, and failure modes. We conclude that Sentinel-1 InSAR can serve as a hazard-screening tool to help guide where to undertake targeted investigations; however, most potential failure modes may not exhibit InSAR-detectable accelerations that could assist with time-of-failure prediction in real time. As such, long-term monitoring programs should ideally be integrated with a combination of remote sensing and field instrumentation to best support engineering practice and judgment.
Changes in movement patterns in relation to sun conditions and spatial scales in wild western gorillas
Authors: Robira B. , Benhamou S. , Obeki Bayanga E. , Breuer T. , Masi S. 
Published: April 2024

Abstract
For most primates living in tropical forests, food resources occur in patchworks of different habitats that vary seasonally in quality and quantity. Efficient navigation (i.e., spatial memory-based orientation) towards profitable food patches should enhance their foraging success. The mechanisms underpinning primate navigating ability remain nonetheless mostly unknown. Using GPS long-term tracking (596 days) of one group of wild western lowland gorillas (Gorilla gorilla gorilla), we investigated their ability to navigate at long distances, and tested for how the sun was used to navigate at any scale by improving landmark visibility and/or by acting as a compass. Long episodic movements ending at a distant swamp, a unique place in the home range where gorillas could find mineral-rich aquatic plants, were straighter and faster than their everyday foraging movements relying on spatial memory. This suggests intentional targeting of the swamp based on long-distance navigation skills, which can thus be efficient over a couple of kilometres. Interestingly, for both long-distance movements towards the swamp and everyday foraging movements, gorillas moved straighter under sunlight conditions even under a dense vegetation cover. By contrast, movement straightness was not markedly different when the sun elevation was low (the sun azimuth then being potentially usable as a compass) or high (so providing no directional information) and the sky was clear or overcast. This suggests that gorillas navigate their home range by relying on visual place recognition but do not use the sun azimuth as a compass. Like humans, who rely heavily on vision to navigate, gorillas should benefit from better lighting to help them identify landmarks as they move through shady forests. This study uncovers a neglected aspect of primate navigation. Spatial memory and vision might have played an important role in the evolutionary success of diurnal primate lineages.
Optimal surgical approach for mid-transverse colon cancer: a systematic review and meta-analysis
Authors: Elkomos Beshoy Effat , Alkomos Philopateer Effat , Alkomos Mina Fransawy , Ahmed Sameh , Baqar Safa Owhida , Bhatti Muhammad Faran Raza , Junaid Rao , Hassan Muddasir , Mazhar Muhammad , Hanna Joseph , Ebeidallah Guirgis Boushra , Ali Ayman Hossam eldin Abd el monaem 
Published: April 2024

Abstract
Background and aim
The incidence of cancer colon has increased dramatically. In addition, the database lacks a review to analyze the outcomes of surgeries for mid-transverse colon cancer with several recent controversial studies. We aimed to compare the outcomes of extended hemicolectomy versus transverse colectomy for mid-transverse colon cancer.

Method
PubMed, Scopes, Web of Science and Cochrane Library were searched for eligible studies from inception to 1 December 2022 and a systematic review and meta-analysis were done to detect.

Results
According to eligibility criteria, 8 studies (2237 patients) were included in our study. The pooled results of the included studies showed no difference in the 5-year OS, 3-year DFS and 5-year DFS between the two types of surgery (5-year OS, RR = 1.15, 95% CI 0.94–1.39, P = 0.17), (3-year OS, RR = 0.96, 95% CI 0.88–1.06, P = 0.42) and (5-year DFS, RR = 1.21, 95% CI 0.91–1.62, P = 0.20). In addition to that, the recurrence rate and the incidence of complications were similar in the two groups (Recurrence rate, RR = 1.08, 95% CI 0.62–1.89, P = 0.79) and (Complications, RR = 1.07, 95% CI 0.74–1.54, P = 0.72). However, the number of LN harvest and the time of the operation were more in case of extended hemicolectomy.

Conclusion
Despite harvesting less LN, transverse colectomy has similar oncological outcomes to extended hemicolectomy for mid-transverse colon cancer. In addition to that, there was no significant difference in the incidence of complications between the two surgeries.
Opening the black box of student government in authoritarian contexts: institutional work and intra-organisational conflicts in the Students’ Guild at Makerere University, Uganda
Authors: Felde Andrea Kronstad 
Published: April 2024

Abstract
Student governments are important actors in higher education governance and also in more general political processes, particularly in Sub-Saharan Africa. Most of the research on student governments has thus far focused on the relations with higher education authorities and political parties, often without investigating their internal dynamics, thus risking of conceiving them as more homogeneous than they are likely to be. Analysing the internal dynamics of student governments is necessary to understand why student leaders, on behalf of their representative organisations, act and position themselves the way they do externally. This case study of the Students’ Guild at Makerere University addresses this knowledge gap by uncovering and analysing internal conflicts of student governments, contributing with new empirical and theoretical insights on students’ institutional behaviour and institutional ambiguity, in the context of authoritarian African states. While internal conflict is expected in any student government, this is anticipated to be even more the case in a conflictual context where there are strong links between students and national authorities. The approach is, in theoretical terms, based on the institutional work perspective and relies on extensive fieldwork at Makerere University. I find that the student government is far more conflictual and heterogenous than previous literature suggests. Rather than comprising representatives who act unitarily, it is characterised by intra-organisational conflicts due to competing institutional work, which reflects representatives’ multiple, diverse and divergent interests and institutional goals.
Safranal exerts a neuroprotective effect on Parkinson’s disease with suppression of NLRP3 inflammation activation
Authors: Yang Wenping , Wei Yongyue , Sun Jin , Yao Caixia , Ai Fen , Ding Haixia 
Published: April 2024

Abstract

Background
Parkinson’s disease (PD) is a common central nervous system neurodegenerative disease. Neuroinflammation is one of the significant neuropathological hallmarks. As a traditional Chinese medicine, Safranal exerts anti-inflammatory effects in various diseases, however, whether it plays a similar effect on PD is still unclear. The study was to investigate the effects and mechanism of Safranal on PD.

Methods
The PD mouse model was established by 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine MPTP firstly. Next, the degree of muscle stiffness, neuromuscular function, motor retardation and motor coordination ability were examined by observing and testing mouse movement behavior. Immunofluorescence staining was used to observe the expression of tyrosine hydroxylase (TH). The dopamine (DA) content of the striatum was detected by High-performance liquid chromatography (HPLC). The expression of TH and NLRP3 inflammasome-related markers NLRP3, IL-1β, and Capase-1 were detected by Real-time Polymerase Chain Reaction (qRT-PCR) and western blotting (WB) respectively.

Results
Through behavioral testing, Parkinson’s mouse showed a higher muscle stiffness and neuromuscular tension, a more motor retardation and activity disorders, together with a worse motor coordination compared with sham group. Simultaneously, DA content and TH expression in the striatum were decreased. However, after using Safranal treatment, the above pathological symptoms of Parkinson’s mouse all improved compared with Safranal untreated group, the DA content and TH expression were also increased to varying degrees. Surprisingly, it observed a suppression of NLRP3 inflammation in the striatum of Parkinson’s mouse.

Conclusions
Safranal played a neuroprotective effect on the Parkinson’s disease and its mechanism was related to the inhibition of NLRP3 inflammasome activation.
Validation of a modified QuEChERS method for the quantification of residues of currently used pesticides in Cuban agricultural soils, using gas chromatography tandem mass spectrometry
Authors: Peña Brizeidi , Sosa Dayana , Hilber Isabel , Escobar Arturo , Bucheli Thomas Daniel 
Published: April 2024

AbstractWe present an analytical method to detect and quantify residues of currently used pesticides (CUPs), which include 31 active ingredients (ai) and seven transformation products (TPs) in tropical and agricultural soils of Cuba. Ten isotopically labeled analogous compounds served as internal standards (IL-IS). The novelty of this research is the inclusion of different tropical soils type scarcely studied for CUPs and TPs, based on the QuEChERS (quick, easy, cheap, effective, rugged and safe) method, followed by chromatography tandem mass spectrometry. All figures of merit proved to be satisfactory according to SANTE guidelines 2020 and 2021. Matrix effects (ME) calculated by the external standard method were significant (|ME| > 20% for almost all compounds; grand mean ± standard deviation (STD) 104 ± 108%) in all soils. The internal standard method compensated ME to non-significant levels (8 ± 50%), even for analytes with a non-structure identical IL-IS (STD, 13 ± 57%). Repeatability (relative standard deviation, RSDr) and reproducibility (RSDR) for skeletic regosol (SR) were 7.5 ± 2.8% and 11.7 ± 4.7%, respectively. Absolute (quantified for 11 analytes with structure identical IL-IS) and relative recovery from SR was 92 ± 13% (mean ± STD) and 90 ± 12%, respectively. Limits of quantification for SR ranged from 0.1 to 10 ng/g, except metalaxyl and oxyfluorfen (25 ng/g each). Linearity of matrix-matched (MM) calibration curves (5 to 100 ng/g) had an R2 of ≥ 0.99 for all soils and almost all analytes. The method was successfully applied to 30 real soil samples.
Almansi-Type Decomposition for Slice Regular Functions of Several Quaternionic Variables
Authors: Binosi Giulio 
Published: April 2024

Abstract
In this paper we propose an Almansi-type decomposition for slice regular functions of several quaternionic variables. Our method yields

$$2^n$$

2
n

distinct and unique decompositions for any slice function with domain in

$$\mathbb {H}^n$$

H

n

. Depending on the choice of the decomposition, every component is given explicitly, uniquely determined and exhibits desirable properties, such as harmonicity and circularity in the selected variables. As consequences of these decompositions, we give another proof of Fueter’s Theorem in

$$\mathbb {H}^n$$

H

n

, establish the biharmonicity of slice regular functions in every variable and derive mean value and Poisson formulas for them.
Teachers’ professional development for inclusion of experimental mathematics and interactive resources in the classroom
Authors: Naftaliev Elena , Barabash Marita 
Published: April 2024

AbstractInformation technology enhances the nature of mathematics as an empirical discipline, leading to an approach called “experimental mathematics” (EM). It fosters the use of technology-based interactive resources (IRs) in mathematics education, giving mathematics an experimental dimension and reflecting a tension between the empirical-inductive nature of IRs and formal mathematics (FM). Our qualitative research focused on professional development (PD) for IR-based teaching of EM intertwined with FM based on a threefold theoretical framework that combines the mathematical knowledge required by EM, the pedagogical functionality of IRs, and instrumental orchestration. The research analyzed 14 high school teachers’ documents generated in the course of a PD program, revealing the evolution of their orientation. We argue that teachers’ evolving orientation toward IR-based EM inclusion in school mathematics is the result of meticulous dynamic PD design implementing three key aspects framed by the threefold theoretical framework: teachers playing various roles during the PD, teacher-researcher collaboration, and theoretical support. The beginning of the evolution of the teachers’ orientation toward IR-based EM inclusion in school mathematics was made possible by a design grounded in the above theoretical framework and observed through its lens.
Coordination of Controllers to Development of Wide-Area Control System for Damping Low-Frequency Oscillations Incorporating Large Renewable and Communication Delay
Authors: Barnawi Abdulwasa Bakr 
Published: April 2024

AbstractThe modern power systems incorporate high penetration of renewable is a large, composite, interconnected network with dynamic behavior. The small disturbances occurring in the system may induce low-frequency oscillations (LFOs) in the system. If the (LFOs) are not suppressed within a stipulated time, it may cause system islanding or even blackouts. Hence, it is essential to investigate the behavior of the system under various levels of disturbances and control action must be taken to damp these oscillations. The established approach to damping the LFOs is by installing power system stabilizers (PSS). PSS uses the local signals from generators to control the oscillations. The dominant source of inter-area oscillations in power systems is due to overloaded weak interconnected lines, converter-interfaced generation, and the action of the high gain exciter present in the system. Consequently, wide area control is needed to control the inter-area oscillations existent in the system. This paper developed a coordinated design of conventional PSS, static compensator, renewable converters, and wide area controller for damping the local and inter-area oscillations in renewable incorporated power systems. The performance of the developed controller is evaluated through the time domain analysis and eigenvalue analysis. A comparison of the introduced controller has been done with other standard conventional methods. The choice of input signals for the wide area controller from the wide-area measurement system is done based on the controllability index. Additionally, the location of the controller must be identified to dampen the inter-area oscillations in the system. In this paper, the controllability index is calculated to find out the highly affected wide area signals for considering it as the feedback signal to a developed controller. The location of the controller is recognized by computing the participation factor. The developed controller has experimented on renewable incorporated large study power systems when time delay and noise are present in wide area signals.
Diffusion approximation of critical controlled multi-type branching processes
Authors: Barczy Mátyás , González Miguel , Martín-Chávez Pedro , del Puerto Inés 
Published: April 2024

AbstractBranching processes form an important family of stochastic processes that have been successfully applied in many fields. In this paper, we focus our attention on controlled multi-type branching processes (CMBPs). A Feller-type diffusion approximation is derived for some critical CMBPs. Namely, we consider a sequence of appropriately scaled random step functions formed from a critical CMBP with control distributions having expectations that satisfy a kind of linearity assumption. It is proved that such a sequence converges weakly toward a squared Bessel process supported by a ray determined by an eigenvector of a matrix related to the offspring mean matrix and the control distributions of the branching process in question. As applications, among others, we derive Feller-type diffusion approximations of critical, primitive multi-type branching processes with immigration and some two-sex branching processes. We also describe the asymptotic behaviour of the relative frequencies of distinct types of individuals for critical CMBPs.
Bedarf für eine School Nurse
Authors: Schlunegger Margarithe Charlotte , Klopfstein Ursula , Siegenthaler Tanja , Berni Seraina , Käser Estelle , Golz Christoph 
Published: April 2024

Zusammenfassung
Hintergrund
Zunehmende gesundheitliche Herausforderungen bei Schüler*innen bringen Schulen an ihre Grenzen. Es sind neue Versorgungsmodelle in Schulen angezeigt, die einen niederschwelligen Zugang zu Gesundheitsleistungen für Schüler*innen gewährleisten, Lehrpersonen entlasten und Eltern unterstützen. Eine School Nurse hat das Potenzial, Lücken in der Versorgung von Schüler*innen zu schließen.

Ziel
Ziel war, den Bedarf und die Erwartungen an eine School Nurse zu erfassen.

Methode
Es wurde eine qualitative Studie durchgeführt. Die Datensammlung erfolgte von September 2022 bis Februar 2023. Wir haben 35 Einzelinterviews mit Schüler*innen, Eltern, Lehrpersonen, Schulleitungen, Schulsozialarbeiter*innen, Pädiater*innen, schulärztlichem Dienst und Gemeinderät*innen von 2 außerstädtischen Schulen in der Schweiz geführt. Die qualitativen Daten wurden mittels induktiver thematischer Analyse von Braun und Clarke analysiert.

Ergebnisse
Aus den Interviews mit allen Teilnehmenden ging mehrheitlich hervor, dass ein Bedarf für eine School Nurse vorhanden war. Wir identifizierten 4 übergeordnete Themen: (1) Entlastung durch niederschwelliges Angebot; (2) Ansprechperson für Gesundheit (Information und Beratung); (3) Versorgung von Unfällen; (4) Versorgung von chronisch kranken Kindern. Die Fachpersonen in der Schule erwähnten zusätzlichen Bedarf, wie Verantwortung abgeben können, Handlungsbedarf bei psychischer Gesundheit, Integration von Gesundheitsförderung und Sicherheit. Jedoch wurde geäußert, dass die Aufgabenbereiche, die Schnittstellen-Kommunikation und die interprofessionelle Zusammenarbeit geklärt werden müssen. Als mögliches Hindernis bei einer Implementierung wurde die Finanzierung genannt.

Schlussfolgerung
Es besteht sowohl bei Schüler*innen, Eltern als auch bei Fachpersonen in der Schule ein Bedarf in Bezug auf die Gesundheitsversorgung. Damit eine genügende Auslastung der School Nurse gewährleistet ist, sollte der Dienst mobil bei mehreren Schulen aufgebaut werden und vorwiegend in Agglomerationen oder ländlichen Gebieten vorhanden sein. Die Finanzierung ist nicht abschließend geklärt. Die interprofessionelle Erarbeitung eines klaren Stellenprofils ist erforderlich, damit eine Grundlage für die zukünftige Zusammenarbeit vorliegt.