bluuebunny/crossref_metadata_2025_split huggingface dataset:
Insulin Human (rDNA Origin) Inhalation Powder
Authors: Cada Dennis J. , Levien Terri , Baker Danial E. 
Published: August 2010

Each month, subscribers to The Formulary Monograph Service receive five to six well-documented monographs on drugs that are newly released or are in late phase 3 trials. The monographs are targeted to your Pharmacy and Therapeutics Committee. Subscribers also receive monthly one-page summary monographs on the agents that are useful for agendas and pharmacy/nursing in-services. A comprehensive target drug utilization evaluation (DUE) is also provided each month. With a subscription, the monographs are sent to you in print and CD ROM forms and are available online. Monographs can be customized to meet the needs of your facility. Subscribers to the The Formulary Monograph Service also receive access to a pharmacy bulletin board, The Formulary Information Exchange (The F.I.X.). All topics pertinent to clinical and hospital pharmacy are discussed on The F.I.X. Through the cooperation of The Formulary, Hospital Pharmacy publishes selected reviews in this column. If you would like information about The Formulary Monograph Service or The F.I.X., call The Formulary at 800-322-4349. The June 2006 monograph topics are faropenen medoxomil, sodium phosphate monobasic monhohydrate and sodium phasphate dibasic anhydrous, methylphendate transdermal, naltrexone extended-release injectable, and sitagliptin. The DUE is on insulin human inhalation powder.
Antibiotic Order Forms
Authors: Scott Leigh Anne 
Published: August 2010

Patient safety is a complex issue that is constantly evolving. Communication via standardized drug ordering is recognized as one of the key elements to providing a safer hospital stay, as well as a stronger patient outcome. This feature will publish bimonthly and will provide examples of standardized drug prescribing and a forum for discussion. If you have a template that you believe other hospital pharmacies can benefit from, please submit it along with answers to the questions (seen below in the text)
IV Potassium Given Epidurally: Getting to the “Route” of the Problem; Acetaminophen Toxicity: More Risk Exposure than We Thought?; Color Consistency
Authors: Cohen Michael R. 
Published: August 2010

These medication errors have occurred in health care facilities at least once. They will happen again—perhaps where you work. Through education and alertness of personnel and procedural safeguards, they can be avoided. You should consider publishing accounts of errors in your newsletters and/or presenting them in your inservice training programs. Your assistance is required to continue this feature. The reports described here were received through the USP Medication Errors Reporting Program (MERP), which is presented in cooperation with the Institute for Safe Medication Practices. If you have encountered medication errors and would like to report them, you may call USP toll-free, 24 hours a day, at 800-233-7767 (800-23-ERROR). Any reports published by ISMP will be anonymous. Comments are also invited; the writers' names will be published if desired. ISMP may be contacted at the address shown below. Errors, close calls, or hazardous conditions may be reported through the ISMP ( www.ismp.org ) or USP ( www.usp.org ) Web sites or communicated directly to ISMP by calling 800-FAIL-SAFE or via E-mail at ismpinfo@ismp.org . ISMP guarantees the confidentiality and security of the information received and respects reporters' wishes as to the level of detail included in publications.
Anidulafungin
Authors: Cada Dennis J. , Levien Terri , Baker Danial E. 
Published: August 2010

Each month, subscribers to The Formulary Monograph Service receive five to six well-documented monographs on drugs that are newly released or are in late phase 3 trials. The monographs are targeted to your Pharmacy and Therapeutics Committee. Subscribers also receive monthly one-page summary monographs on the agents that are useful for agendas and pharmacy/nursing in-services. A comprehensive target drug utilization evaluation (DUE) is also provided each month. With a subscription, the monographs are sent to you in print and CD ROM forms and are available online. Monographs can be customized to meet the needs of your facility. Subscribers to the The Formulary Monograph Service also receive access to a pharmacy bulletin board, The Formulary Information Exchange (The F.I.X.). All topics pertinent to clinical and hospital pharmacy are discussed on The FI.X. Through the cooperation of The Formulary, Hospital Pharmacy publishes selected reviews in this column. If you would like information about The Formulary Monograph Service or The F.I.X., call The Formulary at 800-322-4349. The July 2006 monograph topics are decitabine, varenicline, alglucosidase alfa, garenoxacin, and vildagliptin. The DUE is on rasagiline.
The Use of Combination Antimicrobials in Critically-Ill Ventilated Patients with Pseudomonal Pneumonia
Authors: Peeters Michael J. , Seifert Charles F. 
Published: August 2010

Purpose Recent 2005 American Thoracic Society and Infectious Diseases Society of America ventilator-associated pneumonia (VAP) guidelines suggest combination antimicrobial therapy for Pseudomonas aeruginosa VAP based on limited non-VAP evidence. We reviewed antimicrobial use in patients with P. aeruginosa VAP within our tertiary teaching institution to evaluate patient factors, antimicrobial selection, and outcomes. Methods Intubated patients with a P. aeruginosa sputum culture, infiltrate on chest x-ray, and increased white blood cell count were retrospectively enrolled. Collected data identified illness acuity using the Simplified Acute Physiology Score II (SAPS), culture sensitivities, antimicrobial use, and patient survival at hospital discharge. Results Fifty-nine patients were analyzed between January 2003 and November 2004. Average age was 57 ± 15.7, body mass index (BMI) of 28.5 ± 6.1, and SAPS of 45.1 ± 13.7. Survival was significantly higher among patients on two culture-sensitive antimicrobials (23/28, 82%) vs less than two agents (12/31, 39%; P = 0.0018). Almost all patients who received the beta-lactam and aminoglycoside (BL/Ag) combination survived (15/16; P = 0.0015). While fewer severely ill patients lived (SAPS greater than 54; 4/16; P = 0.0029), none were placed on the BL/Ag combination, and few on appropriate antimicrobials (6/37; P = 0.0324). Lower survival was seen among obese patients (BMI higher than 30; 9/25; P = 0.0043); although, 5/6 obese patients on BL/Ag survived ( P = 0.0237). Patients more than 64-years-old were more often on two appropriate antimicrobials ( P = 0.0143) and had a higher survival ( P = 0.0241). Unfortunately, we observed a lack of culture follow-up, as only 60% (30/50) of inappropriate antimicrobials were switched to sensitive agents. Conclusions Our results emphasize the need to use combination BL/Ag antimicrobials for P aeruginosa VAP as the current guidelines suggest, and to ensure that antimicrobials are optimized based on culture results.
Ibandronate Intravenous
Authors: Cada Dennis J. , Levien Terri , Baker Danial E. 
Published: August 2010

Each month, subscribers to The Formulary Monograph Service receive five to six well-documented monographs on drugs that are newly released or are in late phase 3 trials. The monographs are targeted to your Pharmacy and Therapeutics Committee. Subscribers also receive monthly one-page summary monographs on the agents that are useful for agendas and pharmacy/nursing in-services. A comprehensive target drug utilization evaluation (DUE) is also provided each month. With a subscription, the monographs are sent to you in print and CD ROM forms and are available online. Monographs can be customized to meet the needs of your facility. Subscribers to the The Formulary Monograph Service also receive access to a pharmacy bulletin board, The Formulary Information Exchange (The F.I.X.). All topics pertinent to clinical and hospital pharmacy are discussed on The FI.X. Through the cooperation of The Formulary, Hospital Pharmacy publishes selected reviews in this column. If you would like information about The Formulary Monograph Service or The F.I.X., call The Formulary at 800-322-4349. The September 2006 monograph topics are dasatinib, darunavir, ranibizumab injection, oxymorphone HCl extended-release tablets/oxymorphone HCl tablets, and 17a-hydroxyprogesterone caproate. The DUE is on oxymorphone
Effects of an Automated Drug Dispensing System on Medication Adverse Event Occurrences and Cost Containment at SAMSO
Authors: Dib Jean G. , Abdulmohsin Saud A. , Farooki Masood U. , Mohammed Khurram , Iqbal Mohammed , Khan Jamal Ahmed 
Published: August 2010

Purpose To evaluate the impact of an automated drug dispensing system (ADDS) on cost containment and medication adverse event (MAE) occurrences at Saudi Aramco Medical Services Organization (SAMSO). Method An ADDS replaced the traditional unit-dose cassette-exchange and open floor-stock medication systems at SAMSO in early 2005 on five nursing units. Data collection for MAE occurrences and pharmacy medication supply to these units were performed pre- and postimplementation of the ADDS. Results Reported MAEs decreased by approximately 27%. The overall medication issuance decreased by an average of 43%, corresponding to overall medication cost reduction by an average of 42%. Conclusion Implementation of an ADDS improved the efficiency of drug distribution, assisted in cost containment, and decreased the total number of MAEs.
Ultrafine Clay Minerals of the Pleistocene Olorgesailie Formation, Southern Kenya Rift: Diagenesis and Paleoenvironments of Early Hominins
Authors: Deocampo Daniel M. , Behrensmeyer Anna K. , Potts Richard 
Published: August 2010

AbstractThe Pleistocene Olorgesailie Formation in the southern Kenya Rift has yielded a remarkable assemblage of Acheulean artifacts and vertebrate fossils, including hominin specimen KNM-OG 45500. Members 1 and 7 both contain clay-rich deposits that have been pedogenically modified into paleosols (UM1p and UM7p, respectively). This study provides the first detailed mineralogical and geochemical analyses of the clays of this important Pleistocene basin. The smectitic clays, which show abundant evidence for pedogenesis, were apparently originally deposited under lacustrine conditions. They have an average structural formula of (Ca0.01Na0.32K0.26)(Si3.76Al0.24)(Al0.86Ti0.04Fe0.68Mg0.42)O10(OH)2. The high layer charge clays indicate diagenetic alteration of detrital clay derived from the volcanic drainage basin, probably involving alkaline waters of variable salinity. Despite overall lower salinity compared to other Plio–Pleistocene basins of the region (e.g.Olduvai Gorge), the basin still shows evidence for authigenic clay mineral precipitation. Clay chemistry and bulk geochemical indicators of pedogenesis imply that UM1p clays more closely reflect depositional paleo-waters, whereas UM7p clays have been more pedogenically altered due to subaerial exposure. UM1p smectites show some Mg enrichment near the western Lava Hump locality, consistent with discharge of Mg-bearing paleo-waters from a volcanic aquifer into a siliceous and alkaline (though not highly saline) paleo-lake. UM7p smectites were deposited in a more saline paleo-lake, but have lost substantial amounts of Mg due to post-depositional weathering. Locally abundant artifacts and vertebrate fossils found in these deposits accumulated at times following deposition of the lacustrine clay, probably concurrent with pedogenesis. The limnological conditions associated with initial clay deposition, therefore, preceded hominin occupation of the exposed surfaces.
Porosity Evolution of Free and Confined Bentonites during Interlayer Hydration
Authors: Likos William J. , Wayllace Alexandra 
Published: August 2010

AbstractMethods for predicting the volume change and swelling-pressure behavior of expansive clays require detailed understanding of coupled interactions between clay microstructure and macrostructure under hydraulic, thermal, and mechanical loads. In this study a suite of water-vapor sorption experiments was conducted using compacted bentonites hydrated in controlled relative humidity (RH) environments maintained under free and constrained volume-change boundary conditions. Emphasis was placed on examining the influences of compaction and predominant exchange cation on the water uptake, volume change, and swelling pressure response. Densely compacted specimens exhibited greater volume changes under free swelling conditions and greater swelling pressures under fully confined conditions. Water uptake, volume change, and swelling pressure were all more significant for Colorado (Ca2+/Mg2+) bentonite than forWyoming (Na+) bentonite. Plastic yielding, evident as a peak in the relationship between swelling pressure and RH, was more evident and occurred at lower RH for the Colorado bentonite. This observation was interpreted to reflect the limited capacity for interlayer swelling in Ca2+/Mg2+ bentonites and corresponding structural collapse induced by the onset of water uptake in larger intra-aggregate and inter-aggregate pores. A semi-quantitative model for the evolution of clay microstructure resulting from interlayer hydration was considered to attribute the experimental observations to differences in the efficiency with which transitions in basal spacing translate to bulk volume changes and swelling pressure. Results provide additional insight and experimental evidence to more effectively model the mechanical behavior of compacted bentonites used as buffer or barrier materials in waste repository applications.
Application of Box—Behnken Design to Modeling the Effect of Smectite Content on Swelling to Hydrocyclone Processing of Bentonites with Various Geologic Properties
Authors: Özgen Selçuk , Yildiz Ahmet 
Published: August 2010

AbstractAs advances in technology have led to increased use of bentonites, more high-quality bentonite has been sought. The volume of high-quality bentonites available is shrinking and use of bentonite reserves containing impurities is inevitable. The aim of this study was to apply Box–Behnken experimental design and response surface methodology to model and optimize some operational parameters of a hydrocyclone to produce three groups of bentonite concentrates. The four significant operational parameters of hydrocyclones are feed solid ratio, inlet pressure, vortex diameter, and apex diameter, and these parameters were varied and the results evaluated using the Box–Behnken factorial design. In order to produce bentonite concentrates using a hydrocyclone, mathematical model equations were derived by computer simulation programming applying a least-squares method, using Minitab 15. Second-order response functions were produced for the swelling and to establish the quantity of smectite in the bentonite concentrates. Predicted values were found to be in good agreement with the experimental values (R2 values of between 0.829 and 0.999 for smectite and three different swelling groups for the bentonites). Although in natural states these bentonites are not suitable for industrial use, enhancements were obtained giving up to 81.45% smectite and by increasing swelling by 194% for the three bentonite groups. The swelling properties of the bentonites are improved by increasing the proportion of smectite content. The graphics were designed to relate swelling and smectite content according to the two-dimensional hydrocyclone factors, and each factor was evaluated in itself. The present study revealed that the Box–Behnken and response surface methodology can be applied efficiently to model the hydrocyclone for bentonite; the method is economical and provides the maximum amount of information in a short period of time and with the smallest numberof experiments.
A Child With an FGFR3 Mutation, a Laterality Disorder and an Hepatoblastoma: Novel Associations and Possible Gene–Environment Interactions
Authors: Baynam Gareth S. , Goldblatt Jack 
Published: August 2010

AbstractWe report on a 3-year-old girl, from a 3-generation family with an FGFR3 Pro250Arg mutation, who in addition to craniosynostosis, had a laterality disorder and hepatoblastoma, following a pregnancy complicated by maternal insulin-dependent diabetes. The clinical features possibly result from the combined effects of the maternal diabetes and the familial FGFR3 mutation, thus representing a unique gene–environment interaction that may have implications for the understanding of the phenotypes described in this child.
Are Attitudes Towards Economic Risk Heritable? Analyses Using the Australian Twin Study of Gambling
Authors: Le Anh T. , Miller Paul W. , Slutske Wendy S. , Martin Nicholas G. 
Published: August 2010

AbstractThis study employs multiple regression models based on DeFries and Fulker (1985), and a large sample of twins, to assess heritability in attitudes towards economic risk, and the extent to which this heritability differs between males and females. Consistent with Cesarini et al. (2009), it is found that attitudes towards risk are moderately heritable, with about 20 percent of the variation in these attitudes across individuals being linked to genetic differences. This value is less than one-half the estimates reported by Zyphur et al. (2009) and Zhong et al. (2009). While females are more risk averse than males, there is no evidence that heritability in attitudes towards risk differs between males and females. Even though heritability is shown to be important to economic risk-taking, the analyses suggest that multivariate studies of the determinants of attitudes towards risk which to not take heritability into consideration still provide reliable estimates of the partial effects of other key variables, such as gender and educational attainment.
Heritability of Head Size in Dutch and Australian Twin Families at Ages 0–50 Years
Authors: Smit Dirk J. A. , Luciano Michelle , Bartels Meike , van Beijsterveldt Catharine E. M. , Wright Margaret J. , Hansell Narelle K. , Brunner Han G. , Estourgie-van Burk G. Frederiek , de Geus Eco J. C. , Martin Nicholas G. , Boomsma Dorret I. 
Published: August 2010

AbstractWe assessed the heritability of head circumference, an approximation of brain size, in twin-sib families of different ages. Data from the youngest participants were collected a few weeks after birth and from the oldest participants around age 50 years. In nearly all age groups the largest part of the variation in head circumference was explained by genetic differences. Heritability estimates were 90% in young infants (4 to 5 months), 85–88% in early childhood, 83–87% in adolescence, 75% in young and mid adulthood. In infants younger than 3 months, heritability was very low or absent. Quantitative sex differences in heritability were observed in 15- and 18-year-olds, but there was no evidence for qualitative sex differences, that is, the same genes were expressed in both males and females. Longitudinal analysis of the data between 5, 7, and 18 years of age showed high genetic stability (.78 > RG> .98). These results indicate that head circumference is a highly heritable biometric trait and a valid target for future GWA studies.
Influence of Gestational Diabetes Mellitus on Weight Discrepancy in Twin Pregnancies
Authors: Klein Katharina , Mailath-Pokorny Mariella , Leipold Heinz , Krampl-Bettelheim Elisabeth , Worda Christof 
Published: August 2010

AbstractObjective:To evaluate the influence of gestational diabetes mellitus on weight discrepancy in twin pregnancies.Methods:200 twin pregnancies were included in the study. 157 nondiabetic pregnant women with twin gestations and 43 twin pregnancies with gestational diabetes mellitus (GDM) with viable fetuses born after 24 weeks of gestation were enrolled. Influence of maternal age, body-mass-index at the time of the oral glucose tolerance test, parity, smoking, chorionicity, gestational age at delivery and diagnosis of GDM on weight discrepancy of the twins was evaluated.Results:Mean weight discrepancy of all analyzed twin pregnancies was 285 grams (± 231), relative weight discrepancy was 11.3% (± 8.6). Univariate regression analyses showed that GDM, chorionicity and gestational age at delivery were significantly associated with weight discrepancy. In the multivariate model only diagnosis of GDM was significantly associated with weight discrepancy.Conclusion:Twin pregnancies with insulin requiring gestational diabetes seem to have less birth weight discrepancy than twin pregnancies with normal glucose tolerance.
Promising Antipoverty Strategies for Families
Authors: Cancian Maria , Meyer Daniel R. , Reed Deborah 
Published: August 2010

AbstractA large percentage of poor children live with just one parent, usually their mother, and single‐parent families are more vulnerable to economic downturns than are two‐parent families. Living arrangements also affect the optimal design of policies related to income support and child support. In this paper we briefly review changes in family structure and the relationship between family structure and employment, and then focus on policies that are essential to reducing poverty in the context of the current work‐based safety net, in which low‐income families with children rely increasingly on mothers' earnings. We argue that economically vulnerable families will benefit the most from policies that support resident parents' efforts to balance work and caretaking, and that support and enforce nonresident parents' contributions. We highlight key policies that help resident parents balance responsibilities, including support for access to child care and preschool, family‐friendly workplace policies, and earnings supplements (e.g., the EITC). We also outline a set of policies designed to support and require nonresident parents' contributions, including reforms aimed at creating a child support enforcement system clearly focused on improving child well‐being, rather than government cost recovery, and policies supporting nonresident parents' ability to work and pay support.
Explaining Public Attitudes toward Fighting Inequality in Latin America
Authors: Morgan Jana , Kelly Nathan J. 
Published: August 2010

AbstractThis paper uses the 2008 Americas Barometer survey data from 22 countries to explore the factors that shape Latin American attitudes about the role of the state in reducing inequality. Using multilevel analysis to properly model both the individual‐ and country‐level predictors of these attitudes, we find that traditional explanations of public attitudes about government's redistributive role also carry weight in Latin America. Economic evaluations, personal wealth, trust in government, and assessments of government performance are each associated in predictable ways with attitudes about redistribution. But the analysis also identifies factors that have been overlooked in previous research on the state's role in combating inequality, which has been primarily conducted in the context of the developed world. Namely, we find that Latin Americans appropriately view crime and inequality as interrelated, and as their perceptions of crime as a problem increase so does their support for government efforts to reduce inequality. This relationship is particularly important in poorer countries where inequality and poverty are widespread social ills. The analysis suggests that in the Latin American context it is appropriate to view pursuing anticrime and anti‐inequality policies as compatible rather than competing goals.