bluuebunny/crossref_metadata_2025_split huggingface dataset:
ChemInform Abstract: Bioactive Flavonoids of the Flowers of Butea monosperma.
Authors: Chokchaisiri Ratchanaporn , Suaisom Channarong , Sriphota Siriluk , Chindaduang Anon , Chuprajob Thipphawan , Suksamrarn Apichart 
Published: September 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis and Biological Evaluation of Some Novel Polysubstituted Pyrimidine Derivatives as Potential Antimicrobial and Anticancer Agents.
Authors: Rostom Sherif A. F. , Ashour Hayam M. A. , Abd El Razik Heba A. 
Published: September 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Chemistry of Trisdecacyclic Pyrazine Antineoplastics: The Cephalostatins and Ritterazines
Authors: Lee Seongmin , LaCour Thomas G. , Fuchs Philip L. 
Published: September 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Amino Acid‐Protecting Groups
Authors: Isidro‐Llobet Albert , Alvarez Mercedes , Albericio Fernando 
Published: September 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis of gem‐Difluorinated Heterocycles Using a Difluoropropargyl Molecular Scaffold
Authors: Arimitsu Satoru , Hammond Gerald B. 
Published: September 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Product Class 4: Benzylic Alcohols
Authors: Porter M. J. 
Published: September 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis of Alkanols by Substitution
Authors: Parsons A. F. 
Published: September 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Membrane Treatment — State of the Art. Part 2. Wastewater Treatment
Authors: Guest R. , Pickle R. S. , Bitcon R. K. , Smith D. W. 
Published: September 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Inward rectifier channel, ROMK, is localized to the apical tips of glial‐like cells in mouse taste buds
Authors: Dvoryanchikov Gennady , Sinclair Michael S. , Perea‐Martinez Isabel , Wang Tong , Chaudhari Nirupa 
Published: September 2009

AbstractCells in taste buds are closely packed, with little extracellular space. Tight junctions and other barriers further limit permeability and may result in buildup of extracellular K+ following action potentials. In many tissues, inwardly rectifying K channels such as the renal outer medullary K (ROMK) channel (also called Kir1.1 and derived from the Kcnj1 gene) help to redistribute K+. Using reverse‐transcription polymerase chain reaction (RT‐PCR), we defined ROMK splice variants in mouse kidney and report here the expression of a single one of these, ROMK2, in a subset of mouse taste cells. With quantitative (q)RT‐PCR, we show the abundance of ROMK mRNA in taste buds is vallate > foliate ≫ palate ≫ fungiform. ROMK protein follows the same pattern of prevalence as mRNA, and is essentially undetectable by immunohistochemistry in fungiform taste buds. ROMK protein is localized to the apical tips of a subset of taste cells. Using tissues from PLCβ2‐GFP and GAD‐GFP transgenic mice, we show that ROMK is not found in PLCβ2‐expressing type II/receptor cells or in GAD‐expressing type III/presynaptic cells. Instead, ROMK is found, by single‐cell RT‐PCR and immunofluorescence, in most cells that are positive for the taste glial cell marker, Ectonucleotidase2. ROMK is precisely localized to the apical tips of these cells, at and above apical tight junctions. We propose that in taste buds, ROMK in type I/glial‐like cells may serve a homeostatic function, excreting excess K+ through the apical pore, and allowing excitable taste cells to maintain a hyperpolarized resting membrane potential. J. Comp. Neurol. 517:1–14, 2009. © 2009 Wiley‐Liss, Inc.
Physical–Chemical Properties and Transfection Activity of Cationic Lipid/DNA Complexes
Authors: Antipina Maria N. , Schulze Ingo , Heinze Martin , Dobner Bodo , Langner Andreas , Brezesinski Gerald 
Published: September 2009

AbstractInvestigation of DNA interactions with cationic lipids is of particular importance for the fabrication of biosensors and nanodevices. Furthermore, lipid/DNA complexes can be applied for direct delivery of DNA‐based biopharmaceuticals to damaged cells as non‐viral vectors. To obtain more effective and safer DNA vectors, the new cationic lipids 2‐tetradecylhexadecanoic acid‐{2‐[(2‐aminoethyl)amino]ethyl}amide (CI) and 2‐tetradecylhexadecanoic acid‐2‐[bis(2‐aminoethyl)amino]ethylamide (CII) were synthesized and characterized. The synthesis, physical–chemical properties and first transfection and toxicity experiments are reported. Special attention was focused on the capability of CIand CIIto complex DNA at low and high subphase pH values. Langmuir monolayers at the air/water interface represent a well‐defined model system to study the lipid/DNA complexes. Interactions and ordering of DNA under Langmuir monolayers of the new cationic lipids were studied using film balance measurements, grazing incidence X‐ray diffraction (GIXD) and X‐ray reflectivity (XR). The results obtained demonstrate the ability of these cationic lipids to couple with DNA at low as well as at high pH value. Moreover, the observed DNA structuring seems not to depend on subphase pH conditions. An influence of the chemical structure of the lipid head group on the DNA binding ability was clearly observed. Both compounds show good transfection efficacy and low toxicity in the in vitro experiments indicating that lipids with such structures are promising candidates for successful gene delivery systems.
Adsorbent Materials for Carbon Dioxide Capture from Large Anthropogenic Point Sources
Authors: Choi Sunho , Drese Jeffrey H. , Jones Christopher W. 
Published: September 2009

AbstractSince the time of the industrial revolution, the atmospheric CO2 concentration has risen by nearly 35 % to its current level of 383 ppm. The increased carbon dioxide concentration in the atmosphere has been suggested to be a leading contributor to global climate change. To slow the increase, reductions in anthropogenic CO2 emissions are necessary. Large emission point sources, such as fossil‐fuel‐based power generation facilities, are the first targets for these reductions. A benchmark, mature technology for the separation of dilute CO2 from gas streams is via absorption with aqueous amines. However, the use of solid adsorbents is now being widely considered as an alternative, potentially less‐energy‐intensive separation technology. This Review describes the CO2 adsorption behavior of several different classes of solid carbon dioxide adsorbents, including zeolites, activated carbons, calcium oxides, hydrotalcites, organic–inorganic hybrids, and metal‐organic frameworks. These adsorbents are evaluated in terms of their equilibrium CO2 capacities as well as other important parameters such as adsorption–desorption kinetics, operating windows, stability, and regenerability. The scope of currently available CO2 adsorbents and their critical properties that will ultimately affect their incorporation into large‐scale separation processes is presented.
Detection of site‐specific glycosylation in proteins using flow cytometry
Authors: Jayakumar Deepak , Marathe Dhananjay D. , Neelamegham Sriram 
Published: September 2009

AbstractWe tested the possibility that we may express unique peptide probes on cell surfaces, and detect site‐specific glycosylation on these peptides using flow cytometry. Such development can enhance the application of flow cytometry to detect and quantify post‐translational modifications in proteins. To this end, the N‐terminal section of the human leukocyte glycoprotein PSGL‐1 (P‐selectin glycoprotein ligand‐1) was modified to contain a poly‐histidine tag followed by a proteolytic cleavage site. Amino acids preceding the cleavage site have a single O‐linked glycosylation site. The recombinant protein called PSGL‐1 (HT) was expressed on the surface of two mammalian cell lines, CHO and HL‐60, using a lentiviral delivery approach. Results demonstrate that the N‐terminal portion of PSGL‐1 (HT) can be released from these cells by protease, and the resulting peptide can be readily captured and detected using cytometry‐bead assays. Using this strategy, the peptide was immunoprecipitated onto beads bearing mAbs against either the poly‐histidine sequence or the human PSGL‐1. The carbohydrate epitope associated with the released peptide was detected using HECA‐452 and CSLEX‐1, monoclonal antibodies that recognize the sialyl Lewis‐X epitope. Finally, the peptide released from cells could be separated and enriched using nickel chelate beads. Overall, such an approach that combines recombinant protein expression with flow cytometry may be useful to quantify changes in site‐specific glycosylation for basic science and clinical applications. © 2009 International Society for Advancement of Cytometry
Prevention of fetal alcohol spectrum disorders
Authors: Floyd R. Louise , Weber Mary Kate , Denny Clark , O'Connor Mary J. 
Published: September 2009

AbstractAlcohol use among women of childbearing age is a leading, preventable cause of birth defects and developmental disabilities in the United States. Although most women reduce their alcohol use upon pregnancy recognition, some women report drinking during pregnancy and others may continue to drink prior to realizing they are pregnant. These findings emphasize the need for effective prevention strategies for both pregnant and nonpregnant women who might be at risk for an alcohol‐exposed pregnancy (AEP). This report reviews evidence supporting alcohol screening and brief intervention as an effective approach to reducing problem drinking and AEPs that can lead to fetal alcohol spectrum disorders. In addition, this article highlights a recent report of the National Task Force on Fetal Alcohol Syndrome and Fetal Alcohol Effect that describes effective interventions to reduce alcohol use and AEPs, and outlines recommendations on promoting and improving these strategies. Utilizing evidence‐based alcohol screening tools and brief counseling for women at risk for an AEP and other effective population‐based strategies can help achieve future alcohol‐free pregnancies. © 2009 Wiley‐Liss, Inc. Dev Disabil Res Rev 2009;15:193–199.
Accelerated thymic atrophy as a result of elevated homeostatic expression of the genes encoded by the TNF/lymphotoxin cytokine locus
Authors: Liepinsh Dmitry J. , Kruglov Andrei A. , Galimov Arthur R. , Shakhov Alexander N. , Shebzukhov Yuriy V. , Kuchmiy Anna A. , Grivennikov Sergei I. , Tumanov Alexei V. , Drutskaya Marina S. , Feigenbaum Lionel , Kuprash Dmitry V. , Nedospasov Sergei A. 
Published: September 2009

AbstractTNF, lymphotoxin (LT)‐α, LT‐β and LIGHT are members of a larger superfamily of TNF‐related cytokines that can cross‐utilize several receptors. Although LIGHT has been implicated in thymic development and function, the role of TNF and LT remains incompletely defined. To address this, we created a model of modest homeostatic overexpression of TNF/LT cytokines using the genomic human TNF/LT locus as a low copy number Tg. Strikingly, expression of Tg TNF/LT gene products led to profound early thymic atrophy characterized by decreased numbers of thymocytes and cortical thymic epithelial cells, partial block of thymocyte proliferation at double negative (DN) 1 stage, increased apoptosis of DN2 thymocytes and severe decline of T‐cell numbers in the periphery. Results of backcrossing to TNFR1‐, LTβR‐ or TNF/LT‐deficient backgrounds and of reciprocal bone marrow transfers implicated both LT‐α/LT‐β to LTβR and TNF/LT‐α to TNFR1 signaling in accelerated thymus degeneration. We hypothesize that chronic infections can promote thymic atrophy by upregulating LT and TNF production.
A bone‐protective role for IL‐17 receptor signaling in ovariectomy‐induced bone loss
Authors: Goswami Jaya , Hernández‐Santos Nydiaris , Zuniga Luis A. , Gaffen Sarah L. 
Published: September 2009

AbstractPost‐menopausal osteoporosis is considered to be an inflammatory process, in which numerous pro‐inflammatory and T‐cell‐derived cytokines play a bone‐destructive role. IL‐17A is the signature cytokine of the pro‐inflammatory Th17 population and plays dichotomous roles in diseases that affect bone turnover. Although IL‐17A promotes bone loss in rheumatoid arthritis, it is protective against pathogen‐induced bone destruction in a periodontal disease model. We used a model of ovariectomy‐induced osteoporosis (OVX) in IL‐17 receptor (IL‐17RA)−/− mice to evaluate the role of the IL‐17A in bone loss caused by estrogen deficiency. Unexpectedly, IL‐17RA−/− mice were consistently and markedly more susceptible to OVX‐induced bone loss than controls. There were no changes in prototypical Th1, Th2 or Th17 cytokines in serum that could account for increased bone loss. However, IL‐17RA−/− mice exhibited constitutively elevated leptin, which further increased following OVX. Consistently, IL‐17A and IL‐17F treatment of 3T3‐L1 pre‐adipocytes inhibited adipogenesis, leading to reduced production of leptin. In addition to its role in regulating metabolism and satiety, leptin can regulate bone turnover. Accordingly, these data show that IL‐17A negatively regulates adipogenesis and subsequent leptin expression, which correlates with increased bone destruction during OVX.
Alumina Doped Ni/YSZ Anode Materials for Solid Oxide Fuel Cells
Authors: He C. R. , Wang W. G. 
Published: September 2009

AbstractThe Al2O3–Ni–YSZ (Y2O3 stabilised ZrO2) anode materials with 0–6 wt% Al2O3 were prepared by tape casting method after being ball‐milled for 48 h. The influence of Al2O3 content on flexural strength, electrical conductivity, open porosity, relative density and thermal expansion coefficient (TEC) of Al2O3–Ni–YSZ anode was investigated. The introduction of Al2O3 significantly enhances the flexural strength of Al2O3–Ni–YSZ anode. The flexural strengths of 430 and 299 MPa are achieved for the specimen containing 0.25 wt% Al2O3 before and after reduction, respectively, while the flexural strengths are 201 and 237 MPa for the Ni–YSZ samples. The density decreases with increasing Al2O3 content and the open porosity increases correspondingly, after being sintered at 1350 °C for 4 h. The electrical conductivity at ambient temperature does not fall off when Al2O3 content is less than 1 wt%, but decreases rapidly when the content is above 3 wt% due to the formation of NiAl2O4. A maximum electrical conductivity of 1418 S cm–1 is obtained in the sample containing 0.5 wt% Al2O3. The TEC of the samples decreases with the introduction of Al2O3 in the temperature range of 20–850 °C.
Cost utility of docetaxel as induction chemotherapy followed by chemoradiation in locally advanced squamous cell carcinoma of the head and neck
Authors: Parthan Anju , Posner Marshall R. , Brammer Caroline , Beltran Philippe , Jansen Jeroen P. 
Published: September 2009

AbstractBackgroundTrial TAX 324 showed that induction chemotherapy with docetaxel plus cisplatin and 5‐fluorouracil (TPF) compared with cisplatin and 5‐fluorouracil (PF) followed by chemoradiation increases survival and time to progression in squamous cell carcinoma of head and neck (SCCHN).MethodsA Markov model was developed to estimate the cost‐effectiveness of induction chemotherapy with docetaxel in the United Kingdom from the payer perspective. Health states were based on the WHO criteria for objective response to cancer treatments. Efficacy and safety data were obtained from the trial. Resource utilization, costs, and utility data were primarily derived from the literature.ResultsA patient on TPF gained 4.1 quality adjusted life years (QALYs) versus 2.0 QALYs for PF patient. Corresponding lifetime costs were £32,440 and £28,718. The cost per QALY gained for TPF versus PF was £1782.ConclusionsTPF is cost‐effective as induction chemotherapy in locally advanced SCCHN compared with PF. Local treatment patterns may impact findings for other countries. © 2009 Wiley Periodicals, Inc. Head Neck, 2009
“Partners in perfection”: Human resources facilitating creation and ongoing implementation of self‐managed manufacturing teams in a small medium enterprise
Authors: Fazzari Alan J. , Mosca Joseph B. 
Published: September 2009

AbstractSmall medium enterprises (SMEs) continue to grow, survive, and prosper throughout the world. Although the management of SMEs feel more positive and confident about their relationships with employees, they also continue to encounter a greater number of challenges than their larger multinational counterparts. These problems are inherent in their structure and predominantly emanate from human resources, outdated business models, and lack of strategic planning. Total Quality Management (TQM), long recognized as a major cultural change strategy for profitability and competitive edge, embraces the concept of total employee involvement in the form of teams. SMEs, however, have been slow to include employees in any ongoing collaborative work environment initiatives. Behind the shortage of sustained team formulation is uncertainty about its long‐term durability, which can be directly related to lack of a continuing centralized organization and facilitation of the process itself. Human resources, often ineffectively used in SMEs, has the skills and knowledge to lead an ongoing breakthrough strategy of self‐managed work teams in an effort to create a sustained high‐performance work system. This article reviews the challenges human resource management faces in SMEs. The authors also present an example of how a human resource department led a lasting change management initiative of facilitating self‐managed work teams throughout a manufacturing SME, which resulted in continuous and sustainable improvements in productivity, quality, turnover, absenteeism, health, on‐time delivery, safety, and product design.
Proteasome inhibition activates the mitochondrial pathway of apoptosis in human CD4+ T cells
Authors: Berges Carsten , Haberstock Heinrich , Fuchs Dominik , Sadeghi Mahmoud , Opelz Gerhard , Daniel Volker , Naujokat Cord 
Published: September 2009

AbstractWe have previously shown that inhibition of the proteolytic activity of the proteasome induces apoptosis and suppresses essential functions of activated human CD4+ T cells, and we report now the detailed mechanisms of apoptosis following proteasome inhibition in these cells. Here we show that proteasome inhibition by bortezomib activates the mitochondrial pathway of apoptosis in activated CD4+ T cells by disrupting the equilibrium of pro‐apoptotic and anti‐apoptotic proteins at the outer mitochondrial membrane (OMM) and by inducing the generation of reactive oxygen species (ROS). Proteasome inhibition leads to accumulation of pro‐apoptotic proteins PUMA, Noxa, Bim and p53 at the OMM. This event provokes mitochondrial translocation of activated Bax and Bak homodimers, which induce loss of mitochondrial membrane potential (ΔΨm). Breakdown of ΔΨm is followed by rapid release of pro‐apoptotic Smac/DIABLO and HtrA2 from mitochondria, whereas release of cytochrome c and AIF is delayed. Cytoplasmic Smac/DIABLO and HtrA2 antagonize IAP‐mediated inhibition of partially activated caspases, leading to premature activation of caspase‐3 followed by activation of caspase‐9. Our data show that proteasome inhibition triggers the mitochondrial pathway of apoptosis by activating mutually independent apoptotic pathways. These results provide novel insights into the mechanisms of apoptosis induced by proteasome inhibition in activated T cells and underscore the future use of proteasome inhibitors for immunosuppression. J. Cell. Biochem. 108: 935–946, 2009. © 2009 Wiley‐Liss, Inc.
One‐pot synthesis of 2H‐thiochromenes via TiCl4‐promoted reaction of 2‐tert‐butylthiobenzaldehydes with activated alkenes
Authors: Lee Chang Hoon , Lee Kee‐Jung 
Published: September 2009

Abstract
magnified imageA facile synthesis of 2H‐thiochromenes through TiCl4‐promoted reaction of 2‐tert‐butylthiobenzaldehydes with activated alkenes is described. J. Heterocyclic Chem., (2009).
Synthesis, characterization, and antimicrobial evaluation of novel 4‐pyrrol‐1‐yl‐5,6,7,8‐tetrahydro‐pyrido[4′,3′:4,5] thieno[2,3‐d]pyrimidine derivatives
Authors: Parmar Kokila , Suthar Bharat , Suthar Arun , Maheta Abhay 
Published: September 2009

Abstract
magnified imageA series of novel 7‐alkyl/aryl sulfonyl‐4‐pyrrol‐1‐yl‐5,6,7,8‐tetrahydro‐pyrido[4′,3′:4,5]thieno[2,3‐d] pyrimidine 6 were synthesized for evaluation of their antibacterial and antifungal activity. The structures were determined by IR, NMR, mass spectroscopy, and elemental analysis. They were screened for activities against bacterial and fungal strains. J. Heterocyclic Chem., (2009).