bluuebunny/crossref_metadata_2025_split huggingface dataset:
ChemInform Abstract: Recent Development in Palladium‐Mediated Synthesis of Oxygen Heterocycles
Authors: Majumdar Krishna C. , Chattopadhyay Buddhadeb , Maji Pradip K. , Chattopadhyay Sudip K. , Samanta Srikanta 
Published: June 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: The Flow′s the Thing... or Is It? Assessing the Merits of Homogeneous Reactions in Flask and Flow
Authors: Valera Fernando E. , Quaranta Michela , Moran Antonio , Blacker John , Armstrong Alan , Cabral Joao T. , Blackmond Donna G. 
Published: June 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Phosphoramidites: Privileged Ligands in Asymmetric Catalysis
Authors: Teichert Johannes F. , Feringa Ben L. 
Published: June 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Discovery and Syntheses of “Superbug Challengers” — Platensimycin and Platencin
Authors: Palanichamy Kalanidhi , Kaliappan Krishna P. 
Published: June 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: New Approaches to the Total Synthesis of the Bryostatin Antitumor Macrolides
Authors: Hale Karl J. , Manaviazar Soraya 
Published: June 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Hydrolytic Reactions of Nucleoside Phosphoramidates: Kinetics and Mechanisms
Authors: Lonnberg Tuomas , Ora Mikko , Lonnberg Harri 
Published: June 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Chemical Modification of Soild Wood and Wood Raw Material for Composites Production with Linear Chain Carboxylic Acid Anhydrides
Authors: Papadopoulos Antonios N. 
Published: June 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis and NMR Spectroscopic Characterization of Organometallics in the Laboratory of Wolfgang von Philipsborn: Reminiscences of Former Graduate Students
Authors: Hafner Andreas , Nanz Daniel , Piantini Umberto , Rentsch Daniel , Taschler Carlo , Zerbe Oliver 
Published: June 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Amino Acids: HPLC Analysis Advanced Techniques
Authors: Halpine Susana Maria 
Published: June 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Thermal Behavior and Non‐isothermal Decomposition Reaction Kinetics of NEPE Propellant with Ammonium Dinitramide
Authors: Pang Weiqiang , Fan Xuezhong , Yi Jianhua , Zhao Fengqi , Xu Huixiang , Li Jizhen , Wang Bozhou , Li Yonghong 
Published: June 2010

AbstractThermal decomposition behavior and non‐isothermal decomposition reaction kinetics of nitrate ester plasticized polyether NEPE propellant containing ammonium dinitramide (ADN), which is one of the most important high energetic materials, were investigated by DSC, TG and DTG at 0.1 MPa. The results show that there are four exothermic peaks on DTG curves and four mass loss stages on TG curves at a heating rate of 2.5 K·min−1 under 0.1 MPa, and nitric ester evaporates and decomposes in the first stage, ADN decomposes in the second stage, nitrocellulose and cyclotrimethylenetrinitramine (RDX) decompose in the third stage, and ammonium perchlorate decomposes in the fourth stage. It was also found that the thermal decomposition processes of the NEPE propellant with ADN mainly have two mass loss stages with an increase in the heating rate, that is the result of the decomposition heats of the first two processes overlap each other and the mass content of ammonium perchlorate is very little which is not displayed in the fourth stage at the heating rate of 5, 10, and 20 K·min−1 probably. It was to be found that the exothermal peak temperatures increased with an increase in the heating rate. The reaction mechanism was random nucleation and then growth, and the process can be classified as chemical reaction. The kinetic equations of the main exothermal decomposition reaction can be expressed as: dα/dt=1012.77(3/2)(1−α)[−ln(1−α)]1/3 e−1.723×104/T. The critical temperatures of the thermal explosion (Tbe and Tbp) obtained from the onset temperature (Te) and the peak temperature (Tp) on the condition of β→0 are 461.41 and 458.02 K, respectively. Activation entropy (ΔS≠), activation enthalpy (ΔH≠), and Gibbs free energy (ΔG≠) of the decomposition reaction are −7.02 J·mol−1·K−1, 126.19 kJ·mol−1, and 129.31 kJ·mol−1, respectively.
Thermodynamic Study of Myelin Basic Protein upon Interaction with [Hg2+] Using Extension Solvation Model
Authors: Rezaei Behbehani G. , Saboury A. A. , Zarean O. , Barzegar L. , Ghamamy S. 
Published: June 2010

AbstractMercury ion interaction with myelin basic protein (MBP) was studied at 300 K in 30 mmol/L tris buffer, pH=7 by isothermal titration calorimetry (ITC). An extended solvation model was used for Hg2++MBP interaction over the whole range of Hg2+ concentrations. The binding parameters recovered from the solvation model were attributed to the structural changes of MBP due to its interaction with mercury ion. It was found that mercury ion acted as a noncooperative effector of MBP, and there is a set of two identical and independent binding sites for Hg2+ ions. The dissociation equilibrium constant is 97.6 µmol/L. The molar enthalpy change of binding is −11.25 kJ·mol−1.
Density Functional Theory Study on Hydrogen Bonding Interaction of Catechin‐(H2O)n
Authors: Hu Feng , Zhang Ying , Zhang Hong , Li Laicai , Tian Anmin 
Published: June 2010

AbstractDensity functional theory B3LYP method with 6‐31G* basis set has been used to optimize the geometries of the catechin, water and catechin‐(H2O)n complexes. The vibrational frequencies have been studied at the same level to analyze these complexes. Six and eleven stable structures for the catechin‐H2O and catechin‐(H2O)2 have been found, respectively. Theories of atoms in molecules (AIM) and natural bond orbital (NBO) have been utilized to investigate the hydrogen bonds involved in all the systems. The interaction energies of all the complexes corrected by basis set superposition error, are from −13.27 to −83.56 kJ/mol. All calculations also indicate that there are strong hydrogen‐bonding interactions in catechin‐water complexes. The strong hydrogen‐bonding contributes to the interaction energies dominantly. The O–H stretching motions in all the complexes are red‐shifted relative to that of the monomer.
Kinetics and Mechanism Study of Chemical Treatment of Methylene Green by Urea
Authors: Ahmed Tehseen , Uddin Fahim , Azmat Rafia 
Published: June 2010

AbstractThe kinetics and mechanism studies, for the reduction of methylene green (MG) by urea, in acidic and alkali media, were studied at λmax=652.8 nm by monitoring the depletion in MG concentration. The reaction was carried out by UV radiation, with variable dye concentration, reducing agent (urea), acid and base under different additive ions that are very common in dye waste water. The reduction followed pseudo first‐order kinetics with respect to different anions, cations, dye, reductant and OH− ion concentrations. It was found that most of the cations tested showed the inhibitory effect on dye decoloration, due to the formation of insoluble precipitate and followed the order K+>Na+>Al3+>Ca2+≈Mg2+. Tested anions showed that the dye decoloration was significantly accelerated and followed the order Cl−>Br−>I−>NO−3>SO2−4. A mechanistic model involving generation of a complex of dye with ions was proposed.
One‐Pot Synthesis of 1,4‐Dihydropyridine and Polyhydro‐quinoline Derivatives via L‐Proline Catalyzed Hantzsch Multicomponent Reaction under Ultrasound Irradiation
Authors: Guo Shengrong , Yuan Yanqin 
Published: June 2010

AbstractL‐Proline efficiently catalyzed the multi‐component Hantzsch reaction in EtOH at 60°C under ultrasound irradiation to afford the corresponding 1,4‐dihydropyridine and polyhydroquinoline derivatives in high yields. This method offers the advantages of neutral and mild reaction conditions, high to excellent yields of the products and simple workup.
Synthesis of Novel Unsymmetric Bisbenzimidazoles
Authors: Mao Zhengzhou , Wang Zhaoyang , Mei Wenjie , Yang Kai 
Published: June 2010

AbstractUsing chloroacetic acid, p‐hydroxyl aromatic aldehydes 1 and aromatic diamines 3 as starting materials, novel bisbenzimidazoles 5 with unsymmetric structure were synthesized via aryloxyacetic acid intermediates 2. Four new intermediates 4 and ten target molecules 5 were characterized by FTIR, 1H NMR, 13C NMR, MS and elemental analysis. Different synthetic methods, including one‐pot synthesis and intermittent microwave promotion, were investigated. The research provides a new method and idea for the synthesis of bisbenzimidazoles.
Removal of Brilliant Green Dye from Aqueous Solutions Using Home Made Activated Carbons
Authors: Calvete Tatiana , Lima Eder C. , Cardoso Natali F. , Dias Silvio L. P. , Ribeiro Emerson S. 
Published: June 2010

AbstractActivated carbon materials were prepared from the Brazilian pine‐fruit shell (Araucaria angustifolia) by chemically activated carbon (CAC) and chemically and physically activated carbon (CPAC), and tested as adsorbents for the removal of brilliant green (BG) dye from aqueous effluents. The mixed activation process leads to increases in the specific surface area, average porous volume, and average porous diameter of the adsorbent CPAC when compared to CAC. The effects of shaking time, adsorbent dosage and pH on the adsorption capacity were studied. BG uptake was favorable at pH values ranging from 2.0 to 10.0 for both CAC and CPAC. The contact time required to obtain the equilibrium using CAC and CPAC as adsorbents was 4 h at 298 K, respectively. The fractionary‐order kinetic model provided the best fit to experimental data compared with other models. Equilibrium data were better fit to the Sips and Redlich‐Peterson isotherm models using CAC and CPAC as adsorbents. The enthalpy and entropy of adsorption of BG were obtained from adsorption experiments ranging from 298 to 323 K.
CycloSal‐phosphate Pronucleotides of Cytostatic 6‐(Het)aryl‐7‐deazapurine Ribonucleosides: Synthesis, Cytostatic Activity, and Inhibition of Adenosine Kinases
Authors: Spáčilová Pavla , Nauš Petr , Pohl Radek , Votruba Ivan , Snášel Jan , Zábranská Helena , Pichová Iva , Ameral Ria , Birkuš Gabriel , Cihlář Tomáš , Hocek Michal 
Published: June 2010

AbstractA series of cycloSal‐phosphate prodrugs of a recently described new class of nucleoside cytostatics (6‐hetaryl‐7‐deazapurine ribonucleosides) was prepared. The corresponding 2′,3′‐isopropylidene 6‐chloro‐7‐deazapurine nucleosides were converted into 5‐O′‐cycloSal‐phosphates. These underwent a series of Stille or Suzuki cross‐couplings with diverse (het)arylstannanes or ‐boronic acids to yield the protected 6‐(het)aryl‐7‐deazapurine pronucleotides that were subsequently deprotected to give 12 derivatives of free pronucleotides. The in vitro cytostatic effect of the pronucleotides was compared with parent nucleoside analogues. In most cases, the activity of the pronucleotide was similar to or somewhat lower than that of the corresponding parent nucleosides, with the exception of 7‐fluoro pronucleotides 13 a, 13 b, and 13 d, which had exhibited GIC50 values that were improved by one order of magnitude (to the low nanomolar range). The presence of a cycloSal‐phosphate group also influenced selectivity toward various cell lines. Several pronucleotides were found which strongly inhibit human adenosine kinase but only weakly inhibit the MTB adenosine kinase.
Epigenetic and genetic silencing of CHFR in esophageal adenocarcinomas
Authors: Soutto Mohammed , Peng DunFa , Razvi Mohammad , Ruemmele Petra , Hartmann Arndt , Roessner Albert , Schneider‐Stock Regine , El‐Rifai Wael 
Published: June 2010

AbstractBACKGROUND:The checkpoint with forkhead‐associated domain and RING‐finger domain (CHFR) is a mitotic checkpoint protein with tumor‐suppressor functions. In this study, the authors investigated the epigenetic and genetic mechanisms that regulate CHFR expression in esophageal adenocarcinomas (EACs).METHODS:Quantitative reverse transcriptase polymerase chain reaction analysis demonstrated downregulation of CHFR transcript in 79% of EACs (44 of 56) compared with 41 normal samples (P < .001). Immunohistochemical analysis of CHFR protein expression showed absence or weak immunostaining for CHFR in 75% of EACs (56 of 75) compared with normal tissue samples. The authors next examined the promoter DNA hypermethylation of CHFR by using quantitative bisulfite pyrosequencing technology. They detected significant CHFR promoter DNA hypermethylation in 31% of tumor samples (18 of 58) compared with normal samples (P < .001). Treatment of OE33 cells with 5‐Aza‐deoxycytidine led to reduction in the promoter DNA methylation levels with restoration of the CHFR mRNA expression, which confirmed promoter DNA methylation as an epigenetic mechanism regulating CHFR expression. However, they identified several EACs where the CHFR mRNA expression was silenced in the absence of notable methylation. Therefore, the authors examined the relative DNA copy number level of CHFR compared with normal samples.RESULTS:The results confirmed a decrease or absence of the relative CHFR DNA copy number levels in 59% of tumor samples. Nine tumors that showed loss of CHFR mRNA expression, in absence of promoter DNA hypermethylation, demonstrated a significant loss of relative CHFR DNA copy numbers.CONCLUSIONS:Taken together, their findings demonstrated that both epigenetic and genetic mechanisms were involved in silencing CHFR expression in EACs. Cancer 2010. © 2010 American Cancer Society.
A phase 1 and pharmacodynamic study of decitabine in combination with carboplatin in patients with recurrent, platinum‐resistant, epithelial ovarian cancer
Authors: Fang Fang , Balch Curt , Schilder Jeanne , Breen Timothy , Zhang Shu , Shen Changyu , Li Lang , Kulesavage Carol , Snyder Anthony J. , Nephew Kenneth P. , Matei Daniela E. 
Published: June 2010

AbstractBACKGROUND:Aberrant DNA methylation is a hallmark of cancer, and DNA methyltransferase inhibitors have demonstrated clinical efficacy in hematologic malignancies. On the basis of preclinical studies indicating that hypomethylating agents can reverse platinum resistance in ovarian cancer cells, the authors conducted a phase 1 trial of low‐dose decitabine combined with carboplatin in patients with recurrent, platinum‐resistant ovarian cancer.METHODS:Decitabine was administered intravenously daily for 5 days, before carboplatin (area under the curve, 5) on Day 8 of a 28‐day cycle. By using a standard 3 + 3 dose escalation, decitabine was tested at 2 dose levels: 10 mg/m2 (7 patients) or 20 mg/m2 (3 patients). Peripheral blood mononuclear cells (PBMCs) and plasma collected on Days 1 (pretreatment), 5, 8, and 15 were used to assess global (LINE‐1 repetitive element) and gene‐specific DNA methylation.RESULTS:Dose‐limiting toxicity (DLT) at the 20‐mg/m2 dose was grade 4 neutropenia (2 patients), and no DLTs were observed at 10 mg/m2. The most common toxicities were nausea, allergic reactions, neutropenia, fatigue, anorexia, vomiting, and abdominal pain, the majority being grades 1‐2. One complete response was observed, and 3 additional patients had stable disease for ≥6 months. LINE‐1 hypomethylation on Days 8 and 15 was detected in DNA from PBMCs. Of 5 ovarian cancer‐associated methylated genes, HOXA11 and BRCA1 were demethylated in plasma on Days 8 and 15.CONCLUSIONS:Repetitive low‐dose decitabine is tolerated when combined with carboplatin in ovarian cancer patients, and demonstrates biological (ie, DNA‐hypomethylating) activity, justifying further testing for clinical efficacy. Cancer 2010. © 2010 American Cancer Society.
Relationship between cytokine gene single nucleotide polymorphisms and symptom burden and quality of life in lung cancer survivors
Authors: Rausch Sarah M. , Clark Matthew M. , Patten Christi , Liu Heshan , Felten Sara , Li Yafei , Sloan Jeff , Yang Ping 
Published: June 2010

AbstractBACKGROUND:Previous research has demonstrated that many lung cancer survivors report difficulties with symptom control and experience a poor quality of life (QOL). Although recent studies have suggested a relationship of single nucleotide polymorphisms (SNPs) in several cytokine genes with cancer susceptibility and prognosis, associations with symptom burden and QOL have not been examined. The current study was conducted to identify SNPs related to symptom burden and QOL outcomes in lung cancer survivors.METHODS:All participants were enrolled in the Mayo Clinic Lung Cancer Cohort following diagnosis of lung cancer. A total of 1149 Caucasian lung cancer survivors completed questionnaires and had genetic samples available. The main outcome measures were symptom burden as measured by the Lung Cancer Symptom Scale and health‐related QOL as measured by the Short‐Form General Health Survey.RESULTS:Twenty‐one SNPs in cytokine genes were associated with symptom burden and QOL outcomes. Our results suggested both specificity and consistency of cytokine gene SNPs in predicting outcomes.CONCLUSIONS:These results provide support for genetic predisposition to QOL and symptom burden and may aid in identification of lung cancer survivors at high risk for symptom management and QOL difficulties. Cancer 2010. © 2010 American Cancer Society.
The integrity of authorship
Authors: Pollock Raphael E. , Ewer Michael S. 
Published: June 2010

AbstractSubmissions to peer‐reviewed publications sometimes involve contributions that are financed by industry in ways that that could interfere with the objectivity of the submission. The authors of this commentary consider it essential that all submissions to peer‐reviewed journals be accompanied by full acknowledgements of such contributions so as to insure that those involved in the editorial process as well as the readers of the final published version of an article are fully informed regarding any relationship that could influence objectivity. The authors examined the balance between industry support of a publication and the integrity of authorship. Cancer 2010. © 2010 American Cancer Society.
Intravenous methotrexate as central nervous system (CNS) prophylaxis is associated with a low risk of CNS recurrence in high‐risk patients with diffuse large B‐cell lymphoma
Authors: Abramson Jeremy S. , Hellmann Matthew , Barnes Jeffrey A. , Hammerman Peter , Toomey Christiana , Takvorian Tak , Muzikansky Alona , Hochberg Ephraim P. 
Published: June 2010

AbstractBACKGROUND:The outcome of patients with systemic diffuse large B‐cell lymphoma (DLBCL) had improved over the past decade with the addition of monoclonal antibody therapy. Unfortunately, approximately 5% of these patients still developed a secondary central nervous system (CNS) recurrence followed invariably by rapid death. This rate is substantially increased in patients with certain high‐risk features. Although prophylaxis against CNS recurrence with either intrathecal or intravenous methotrexate is commonly used for such patients, to the authors' knowledge, there is no standard of care. Retrospectively evaluated was the role of high‐dose systemic methotrexate combined with standard cyclophosphamide, doxorubicin, vincristine, and prednisone with rituximab (R‐CHOP) chemotherapy to decrease CNS recurrence in high‐risk patients.METHODS:A total of 65 patients with DLBCL and CNS risk factors were identified at the study institution between 2000 and 2008 who received intravenous methotrexate as CNS prophylaxis concurrent with standard systemic therapy with curative intent. CNS recurrence rate, progression‐free survival, and overall survival were calculated.RESULTS:Patients received a median of 3 cycles of methotrexate at a dose of 3.5 gm/m2 with leucovorin rescue. The complete response rate was 86%, with 6% partial responses. At a median follow‐up of 33 months, there were only 2 CNS recurrences (3%) in this high‐risk population. The 3‐year progression‐free and overall survival rates were 76% and 78%, respectively. Complications associated with methotrexate therapy included transient renal dysfunction in 7 patients and a delay in systemic chemotherapy in 8 patients.CONCLUSIONS:Intravenous methotrexate can be safely administered concurrently with R‐CHOP and is associated with a low risk of CNS recurrence in high‐risk patients. Cancer 2010. © 2010 American Cancer Society.
A Web‐based resource model for scholarship 2.0: object reuse & exchange
Authors: Lagoze Carl , Van de Sompel Herbert , Nelson Michael , Warner Simeon , Sanderson Robert , Johnston Pete 
Published: June 2010

SUMMARYDigital scholarship offers the opportunity to move beyond the limitations of traditional scholarly publication. Rather than limiting scholarly communication to text‐based static documents, the Web makes it possible for scholars to expose and share the full evidence of their research including data, images, video, and other genre of materials. These aggregations of evidence, or compound documents, can then be integrated into a linked data cloud, the basis of Scholarship 2.0—an open environment in which scholars collaborate and build new knowledge on the existing scholarship. We present Open Archives Initiative–Object Reuse and Exchange (OAI–ORE), a set of standards to identify and describe aggregations of WebResources, thereby making the Scholarship 2.0 vision possible. Copyright © 2010 John Wiley & Sons, Ltd.