bluuebunny/crossref_metadata_2025_split huggingface dataset:
Is rainfall intensity significant in the rainfall–runoff process within tropical rainforests of northeast Queensland? The Hewlett regression analyses revisited
Authors: Howard Andrew J. , Bonell Mike , Gilmour Don , Cassells David 
Published: July 2010

AbstractFollowing the statistical analyses of long‐term rainfall‐runoff records from research basins in humid temperate latitudes, Hewlett and co‐workers extended the global challenge to disprove their findings that rainfall intensity was non‐significant. This paper responds to Hewlett's challenge as no preceding analyses have involved forested basins in a tropical cyclone‐prone area. Based on a 7 year rainfall‐runoff record, quickflow (QF), peak flow (QP) and quickflow response ratios (QRR) were regressed as dependent variables against rainfall parameters (intensity, Pi, amount, P), storm duration, D and antecedent flow, I. These data sets were categorised into total streamflow (Q) classes and stratified into three seasons, (monsoon, post‐monsoon and dry) for forested and cleared catchments. Where rainfall variable collinearity met acceptable levels, the addition of Pi to regression models including P, D, I contributed up to 9% and 66% of the respective variations in quickflow and peak flow. For the highest Q storm classes (monsoon), Pi alone accounted for up to 67% and 91% of the variation in QF and QP respectively and was the dominant influence on QP for all seasons. The very high rainfall intensities experienced in the monsoon season is a causal factor why these results differ from those of other research drainage basins. Surprisingly, Pi continued to have a significant influence on QF for dry season classes when less‐intense rainfall occurs. Further the results were similar for both catchments across all seasons. P was the dominant independent variable affecting QF above a threshold Q of 50 mm (monsoon), as rainfall contributes directly to saturation overland flow and return flow under saturated conditions. Further although QRR increased with increasing Q for each season, the regression results for that parameter were poor possibly due to the non‐linearity of the rainfall‐runoff relationship. Copyright © 2010 John Wiley & Sons, Ltd.
Hydrology of hillslope‐wetland streams, Polar Bear Pass, Nunavut, Canada
Authors: Young Kathy L. , Assini Jane , Abnizova Anna , De Miranda Nelson 
Published: July 2010

AbstractPolar Bear Pass is a large High Arctic low‐gradient wetland (100 km2) bordered by low‐lying hills which are notched by a series of v‐shaped valleys. The spring and summer hydrology of two High Arctic hillslope‐wetland catchments, a first‐order stream, 0·2 km2 Landing Strip Creek (LSC) and a larger second‐order basin, 4·2 km2 Windy Creek (WC), is described here. A water balance framework was employed in 2008 to examine the movement of water from upland reaches into the low‐lying wetland. Snowcover was low in both basins (<50 mm in water equivalent units), but they both exhibited nival‐type regimes. After the main snowmelt season ended, runoff ceased in the smaller catchment (LSC), but not at the larger basin (WC) which continued to flow throughout the summer. Both basins responded to summer rains in different ways. At LSC, late‐summer continuous streamflow occurred only when rainfall satisfied the large soil moisture deficit in the upper bowl‐shaped zone of the basin. At WC, the presence of thinly thawed, ice‐rich polygonal terrain within the stream channel and in the upper reaches of the catchment likely limited infiltration in these near‐stream zones and enhanced runoff in response to both moderate and high rainfall. Subsequently, seasonal runoff ratios differed between the two sites (0·19 vs 0·68) as did the seasonal storage + residual (+16 vs −50 mm). This suggests that the post‐snowmelt season runoff response to summer precipitation is very much modified by the unique basin characteristics (soil‐type, vegetation, ground ice) and their location within each stream order type. Copyright © 2010 John Wiley & Sons, Ltd.
Simulation of spatiotemporal dynamics of water fluxes in Germany under climate change
Authors: Huang Shaochun , Krysanova Valentina , Österle Hermann , Hattermann Fred F. 
Published: July 2010

AbstractIn most of Europe, an increase in average annual surface temperature of 0·8 °C is observed, and a further increase is projected. Precipitation tends to increase in northern Europe and decrease in southern Europe, with variable trends in central Europe. The climate scenarios for Germany suggest an increase in precipitation in western Germany and a decrease in eastern Germany, and a shift of precipitation from summer to winter. When investigating the effects of climate change, impacts on water resources are among the main concerns. In this study, the first German‐wide impact assessment of water fluxes dynamics under climate change is presented in a spatially and temporally distributed manner using the state‐of‐the‐art regional climate model, Statistical Regional (STAR) model and the semi‐distributed process‐based eco‐hydrological model, soil and water integrated model (SWIM). All large river basins in Germany (lower Rhine, upper Danube, Elbe, Weser and Ems) are included. A special focus of the study was on data availability, homogeneity of data sets, related uncertainty propagation in the model results and scenario‐related uncertainty. After the model calibration and validation (efficiency from 0·6 to 0·9 in 80% of cases) the water flow components were simulated at the hydrotope level, and the spatial distributions were compared with those in the Hydrological Atlas of Germany. The actual evapotransipration is likely to increase in most parts of Germany, while total runoff generation may decrease in south and east regions. The results for the second scenario period 2051–2060 show that water discharge in all six rivers would be 8–30% lower in summer and autumn compared with the reference period, and the strongest decline is expected for the Saale, Danube and Neckar. Higher winter flow is expected in all of these rivers, and the increase is most significant for the Ems (about 18%). However, the uncertainty of impacts, especially in winter and for high water flows, remains high. Copyright © 2010 John Wiley & Sons, Ltd.
Extreme storms in Malmö, Sweden
Authors: Bengtsson Lars , Milloti Stefan 
Published: July 2010

AbstractShort‐term very intensive storms in the years 1980–2007 from rain gauges in Malmö have been analysed to find intensities of long return periods and to investigate trends. Observations from different stations have been pooled into series to which probability functions have been adjusted. Quality control of short‐term precipitation records is emphasized. In order to investigate whether high rain intensities are different today compared to back in time, new and old rain data have been compared. Trends over the last 25 years have been computed for storms of duration 10 min to 1 h, and for 89 years of daily rains. A literature review of investigations of changing rain intensities is presented. It is found that 10‐ to 25‐year long rain series from single stations are too short to give good estimates of storms of long recurrence time because a single event influences much. The largest observed rains in Malmö in the investigated period have a return period of about 20–50 years. For the very short‐term storms, 50‐year old intensity–duration–frequency curves do not differ much from those derived from new data. Trend analysis shows changing short‐term high storm intensities only for storms of 10‐min duration. Copyright © 2010 John Wiley & Sons, Ltd.
Prediction of hourly actual evapotranspiration using neural networks, genetic programming, and statistical models
Authors: Izadifar Zohreh , Elshorbagy Amin 
Published: July 2010

AbstractThe complexity of the evapotranspiration process and its variability in time and space have imposed some limitations on previously developed evapotranspiration models. In this study, two data‐driven models: genetic programming (GP) and artificial neural networks (ANNs), and statistical regression models were developed and compared for estimating the hourly eddy covariance (EC)‐measured actual evapotranspiration (AET) using meteorological variables. The utility of the investigated data‐driven models was also compared with that of HYDRUS‐1D model, which makes use of conventional Penman–Monteith (PM) model for the prediction of AET. The latent heat (LE), which is measured using the EC method, is modelled as a function of five climatic variables: net radiation, ground temperature, air temperature, relative humidity, and wind speed in a reconstructed landscape located in Northern Alberta, Canada. Several ANN models were evaluated using two training algorithms of Levenberg–Marquardt and Bayesian regularization. The GP technique was used to generate mathematical equations correlating AET to the five climatic variables. Furthermore, the climatic variables, as well as their two‐factor interactions, were statistically analysed to obtain a regression equation and to indicate the climatic factors having significant effect on the evapotranspiration process. HYDRUS‐1D model as an available physically based model was examined for estimating AET using climatic variables, leaf area index (LAI), and soil moisture information. The results indicated that all three proposed data‐driven models were able to approximate the AET reasonably well; however, GP and regression models had better generalization ability than the ANN model. The results of HYDRUS‐1D model exhibited that a physically based model, such as HYDRUS‐1D, might be comparable or even inferior to the data‐driven models in terms of the overall prediction accuracy. Based on the developed GP and regression models, net radiation and ground temperature had larger contribution to the AET process than other variables. Copyright © 2010 John Wiley & Sons, Ltd.
Instream flow requirements for sediment transport in the lower Weihe River
Authors: Song Jinxi , Xu Zongxue , Hui Yanghe , Li Huaien , Li Qi 
Published: July 2010

AbstractEstimation of instream flow requirements for sediment transport (IFRST) in the downstream Weihe River is important for the maintenance of a healthy ecosystem of the river. In this study, the IFRST for the lower Weihe River is estimated on the basis of the observed hydrological data during the period 1960–2001. The results showed that the mean annual IFRSTs for the reach between Lintong and Huaxian and the reach below Huaxian were 6·85 and 7·62 billion m3/year, respectively, and the standard errors were 0·50 and 0·76 billion m3/year, respectively. The results also showed that the Sanmenxia Reservoir is an important driver for the changes in channel morphology and hydraulics, as well as the IFRST. Furthermore, according to the hydrological frequency (p value) estimated from annual instream flow data during the period 1960–2001, four typical years (p = 25%, 50%, 75% and 90%) for the two reaches of the Weihe River were determined. The analysis showed that the IFRST has a negative power functional relationship with the sediment concentration. On the basis of the efficiency coefficients (R2) during three sub‐periods 1960–1973, 1974–1990 and 1991–2001, the annual IFRSTs in the above two reaches for the four typical years were estimated under different deposition and erosion–deposition conditions. The results provide useful references for restoration and water resource management of the Weihe River. Copyright © 2010 John Wiley & Sons, Ltd.
Do biological soil crusts determine vegetation changes in sandy deserts? Implications for managing artificial vegetation
Authors: Li X. R. , Tian F. , Jia R. L. , Zhang Z. S. , Liu L. C. 
Published: July 2010

AbstractBiological soil crusts (BSCs), which are widespread in arid and semiarid regions, such as sandy deserts, strongly influence terrestrial ecosystems. Once sand‐binding vegetation has been established on sand dunes, BSCs are colonized and gradually develop from cyanobacteria dominated crusts to lichen and moss dominated crusts on dune surfaces. We conducted this study to determine if the occurrence and development of BSCs in the Tengger Desert could be used to determine sand‐binding vegetation changes via altering soil moisture and water cycling using long‐term monitoring data and field experimental observation. BSCs changed the spatiotemporal pattern of soil moisture and re‐allocation by decreasing rainfall infiltration, increasing topsoil water‐holding capacity and altering evaporation. Changes in the soil moisture pattern induced shifting of sand‐binding vegetation from xerophytic shrub communities with higher coverage (35%) to complex communities dominated by shallow‐rooted herbaceous species with low shrub coverage (9%). These results imply that BSCs can be a major factor controlling floristic and structural changes in sand‐binding vegetation and suggest that the hydrological effects of BSCs must be considered when implementing large‐scale revegetation projects in sandy deserts. Copyright © 2010 John Wiley & Sons, Ltd.
Assessing sensitivity of hydrologic responses to climate change from forested watershed in Mississippi
Authors: Parajuli Prem B. 
Published: July 2010

AbstractThe climatic processes such as changes in precipitation, temperature and atmospheric CO2 concentration can intensify the effects on water resources. An assessment of the effects of long‐term climate change on water resources is essential to the development of water quality improvement programs. This study was conducted in the Upper Pearl River Watershed (UPRW) in east‐central Mississippi to assess the effects of long‐term potential future climate change on average mean monthly stream flow from the five spatially distributed U. S. Geological Survey (USGS) gage stations in the UPRW using the Soil and Water Assessment Tool. The model was calibrated (January 1981 to December 1994) and validated (January 1995 to September 2008) using monthly measured stream flow data. The calibrated and validated model determined good to very good performance for stream flow prediction (R2 and E from 0·60 to 0·86) between measured and predicted stream flow values. The root mean square error values (from 14 to 37 m3 s−1) were estimated at similar levels of errors during model calibration and validation. The results showed that long‐term (50 years) average monthly stream flow sensitivity due to climate change effects was found the greatest as a result of percentage change in the precipitation followed by carbon dioxide (CO2) concentration and temperature. The long‐term model simulation scenarios as compared with the base scenario for all five spatially distributed USGS gage stations in the UPRW estimated an average monthly stream flow decrease (from 54 to 67%) and average monthly stream flow increase (from 67 to 79%) depending on the spatial characteristics of the USGS gage stations. Overall, the results indicate that the UPRW hydrology is very sensitive to potential future climate changes and that these changes could stimulate increased streamflow generation from the watershed. Copyright © 2010 John Wiley & Sons, Ltd.
Epigenetic regulation of cancer growth by histone demethylases
Authors: Lim Soyoung , Metzger Eric , Schüle Roland , Kirfel Jutta , Buettner Reinhard 
Published: July 2010

AbstractCancer is traditionally viewed as a primarily genetic disorder. However, it is now increasingly apparent that epigenetic abnormalities play a fundamental role in cancer development. Aberrant expression of histone‐modifying enzymes has been implicated in the course of tumor initiation and progression. The discovery of a large number of histone demethylases suggests an important role for dynamic regulation of histone methylation in biological processes. The observation that overexpression, amplification or mutations of several histone demethylases have been found in many types of tumors, raise the possibility of using these enzymes as diagnostic tools as well as pave a way for the discovery of novel therapeutic targets and treatment modalities. Here, we review the current knowledge of the potential role of H3K4, H3K9 and H3K27 histone demethylases in tumorigenesis.
Association between melanoma thickness, clinical skin examination and socioeconomic status: Results of a large population‐based study
Authors: Youl Philippa H. , Baade Peter D. , Parekh Sanjoti , English Dallas , Elwood Mark , Aitken Joanne F. 
Published: July 2010

AbstractSurvival from melanoma is inversely related to tumour thickness and is less favorable for those in lower socioeconomic (SES) strata. Reasons for this are unclear but may relate to a lower prevalence of skin screening. Our aim was to examine the association between melanoma thickness, individual‐level SES and clinical skin examination (CSE) using a population‐based case‐control study. Cases were Queensland (Australia) residents aged 20–75 years with a histologically confirmed first primary invasive cutaneous melanoma diagnosed between January 2000 and December 2003. Telephone interviews were completed by 3,762 cases (77.7%) and 3,824 (50.4%) controls. Thickness was dichotomized to thin (≤2 mm) and thick (>2 mm). Compared with controls, the risk of thick melanoma was significantly increased among men [relative risk ratio (RRR) = 1.56, 95% CI = 1.22–2.00], older participants (RRR = 1.76, 95% CI = 1.10–2.82), those educated to primary level (RRR = 1.70, 95% CI = 1.08–2.66), not married/living as married (RRR = 1.47, 95% CI = 1.15–1.88), retired (RRR = 1.39, 95% CI = 1.01–1.94) and not having a CSE in past 3 years (RRR = 1.45, 95% CI = 1.12–1.86). There was a significant trend to increasing prevalence of CSE with higher education (p < 0.01) and the benefit of CSE in reducing the risk of thick melanoma was most pronounced among that subgroup. There were no significant associations between cases with thin melanoma and controls. Melanoma thickness at presentation is significantly associated with educational level, other measures of SES and absence of CSE. Public health education efforts should focus on identifying new avenues that specifically target those subgroups of the population who are at increased risk of being diagnosed with thick melanoma.
Expression and functional role of negative signalling regulators in tumour development and progression
Authors: Murphy Tania , Hori Satoshi , Sewell James , Gnanapragasam Vincent J. 
Published: July 2010

AbstractAlterations in intracellular signalling pathways such as the mitogen‐activated protein kinases (MAPKs) are key common mechanisms of tumour development and progression. As such, there has been intense research into developing drugs that can inhibit or attenuate intracellular signalling. In recent years, there has been increasing recognition that the cell already has innate negative regulatory proteins that achieve this in normal homeostasis. These regulators provide a feedback inhibitory mechanism that controls the intensity and duration of activated signalling by exogenous stimuli. Members of this group include Raf kinase inhibitor protein 1, the MAPK phosphatases, the SPROUTY and SPRED families and similar expression to FGF. A number of studies have now demonstrated significant alterations in expression of negative regulators in malignant tissue in different cancer types. In functional studies, manipulated expression of these regulators has been shown to significantly influence tumour cell behaviour and phenotype. Here, we summarise the evidence for the functional expression of negative signalling regulators in tumour growth and progression and discuss their potential role as cancer biomarkers and targets for novel drug therapy.
Warburg phenotype in renal cell carcinoma: High expression of glucose‐transporter 1 (GLUT‐1) correlates with low CD8+ T‐cell infiltration in the tumor
Authors: Singer Katrin , Kastenberger Michael , Gottfried Eva , Hammerschmied Christine G. , Büttner Maike , Aigner Michael , Seliger Barbara , Walter Bernhard , Schlösser Hans , Hartmann Arndt , Andreesen Reinhard , Mackensen Andreas , Kreutz Marina 
Published: July 2010

AbstractMany tumor cells are characterized by a dysregulated glucose metabolism associated with increased glycolysis in the presence of oxygen (“Warburg Effect”). Here, we analyzed for the first time a possible link between glucose metabolism and immune cell infiltration in renal cell carcinoma (RCC). RCC specimens revealed a highly significant increase in the expression of lactate dehydrogenase A (LDHA) and glucose‐transporter 1 (GLUT‐1) compared to the corresponding normal kidney tissue on mRNA level. Accordingly, tumor cell lines of different origin such as RCC, melanoma and hepatocellular carcinoma strongly expressed LDHA and GLUT‐1 compared to their nonmalignant counterparts. In line with this finding, tumor cells secreted high amounts of lactate. High expression of GLUT‐1 and LDH5, a tetramer of 4 LDHA subunits, was confirmed by tissue microarray analysis of 249 RCC specimens. Overall, 55/79 (69.6%) and 46/71 (64.7%) cases of clear cell carcinoma showed a constitutive, but heterogeneous expression of GLUT‐1 and LDH5, respectively. The number of CD3+, CD8+ and FOXP3+ T cells was significantly elevated in RCC lesions compared to normal kidney epithelium, but effector molecules such as granzyme B and perforin were decreased in tumor infiltrating T cells. Of interest, further analysis revealed an inverse correlation between GLUT‐1 expression and the number of CD8+ T cells in RCC lesions. Together, our data suggest that an accelerated glucose metabolism in RCC tissue is associated with a low infiltration of CD8+ effector T cells. Targeting the glucose metabolism may represent an interesting tool to improve the efficacy of specific immunotherapeutic approaches in RCC.
Expression levels of hnRNP G and hTra2‐beta1 correlate with opposite outcomes in endometrial cancer biology
Authors: Ouyang Yi Qin , zur Hausen Axel , Orlowska‐Volk Marzenna , Jäger Markus , Bettendorf Herta , Hirschfeld Marc , Tong Xiao Wen , Stickeler Elmar 
Published: July 2010

AbstractHnRNP G is a member of heterogeneous nuclear ribonucleoprotein (hnRNP) family with potent tumor suppressive activities. Human transformer‐2‐beta1 (hTra2‐beta1) belongs to the arginine‐serine rich like proteins and is found over‐expressed in various human cancers. It was recently shown that hnRNP G and hTra2‐beta1 exert antagonistic effects on alternative splicing. In our study we explored the impact of these two factors in tumor biology of endometrial cancer (EC). EC tissues (n = 139) were tested for hnRNP G and hTra2‐beta1 expression on mRNA level by real time PCR and on protein level by immunohistochemistry. HTra2‐beta1 mRNA level was found being induced in advanced International Federation of Gynecology and Obstetrics (FIGO) stages (p = 0.016). HnRNP G protein nuclear expression was found more prominent in patients without distant organ metastases (p = 0.033) and in FIGO Stages I/II group (p < 0.001). HTra2‐beta1 protein nuclear levels were elevated in poorly differentiated (p = 0.044) and lymph node metastases (p = 0.003) cancers. Kaplan‐Meier survival curves revealed that elevated hnRNP G mRNA (p = 0.029) and protein (p = 0.022) levels were associated with a favorable patient outcome. Multivariate Cox‐regression analyses identified nuclear hnRNP G level [hazard ratio (HR) 0.468, p = 0.026) as well as hTra2‐beta1 level (hazard ratio 5.760, p = 0.004) as independent prognostic factors for EC progression‐free survival. Our results indicate that the antagonistic functional effects of hnRNP G and hTra2‐beta1 on alternative splicing correlate directly to their opposite clinical effects on EC patient outcome.