bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mould allergen Alt a 1 spiked with the micronutrient retinoic acid reduces Th2 response and ameliorates Alternaria allergy in BALB/c mice
Authors: Fakhimahmadi Aila , Roth‐Walter Franziska , Hofstetter Gerlinde , Wiederstein Markus , Jensen Sebastian A. , Berger Markus , Szepannek Nathalie , Bianchini Rodolfo , Pali‐Schöll Isabella , Jensen‐Jarolim Erika , Hufnagl Karin 
Published: May 2024

AbstractBackgroundWe investigated the biological function of the mould allergen Alt a 1 as a carrier of micronutrients, such as the vitamin A metabolite retinoic acid (RA) and the influence of RA binding on its allergenicity in vitro and in vivo.MethodsAlt a 1‐RA complex formation was analyzed in silico and in vitro. PBMCs from Alternaria‐allergic donors were stimulated with Alt a 1 complexed with RA (holo‐Alt a 1) or empty apo‐Alt a 1 and analyzed for cytokine production and CD marker expression. Serum IgE‐binding and crosslinking assays to apo‐ and holo‐protein were correlated to B‐cell epitope analysis. Female BALB/c mice already sensitized to Alt a 1 were intranasally treated with apo‐Alt a 1, holo‐Alt a 1 or RA alone before measuring anaphylactic response, serum antibody levels, splenic cytokines and CD marker expression.ResultsIn silico docking calculations and in vitro assays showed that the extent of RA binding depended on the higher quaternary state of Alt a 1. Holo‐Alt a 1 loaded with RA reduced IL‐13 released from PBMCs and CD3+CD4+CRTh2 cells. Complexing Alt a 1 to RA masked its IgE B‐cell epitopes and reduced its IgE‐binding capacity. In a therapeutic mouse model of Alternaria allergy nasal application of holo‐Alt a 1, but not of apo‐Alt a 1, significantly impeded the anaphylactic response, impaired splenic antigen‐presenting cells and induced IL‐10 production.ConclusionHolo‐Alt a 1 binding to RA was able to alleviate Th2 immunity in vitro, modulate an ongoing Th2 response and prevent anaphylactic symptoms in vivo, presenting a novel option for improving allergen‐specific immunotherapy in Alternaria allergy.
Quality‐of‐life outcomes of the ROBOtic‐assisted versus Conventional Open Partial nephrectomy (ROBOCOP) II trial
Authors: Sidoti Abate Marie Angela , Menold Hanna Saskia , Neuberger Manuel , Kirchner Marietta , Haney Caelan Max , Nuhn Philipp , Westhoff Niklas , Honeck Patrick , Michel Maurice‐Stephan , Kriegmair Maximilian Christian , Kowalewski Karl‐Friedrich 
Published: May 2024

ObjectivesTo comprehensively compare quality‐of‐life (QoL) outcomes between open partial nephrectomy (OPN) and robot‐assisted PN (RAPN) from the randomised ROBOtic‐assisted versus Conventional Open Partial nephrectomy (ROBOCOP) II trial, as QoL data comparing OPN and RAPN are virtually non‐existent, especially not from randomised controlled trials (RCTs).Patients and MethodsThe ROBOCOP II was a single‐centre, open‐label RCT between OPN and RAPN. The pre‐planned analyses of QoL outcomes are presented. Data were analysed descriptively in a modified intention‐to‐treat population.ResultsA total of 50 patients underwent surgery. At postoperative Day 90 (POD90), there was no significant difference for the Kidney Disease Quality of Life‐Short Form questionnaire score (mean [sd] OPN 72 [20] vs RAPN 76 [15], P = 0.850), while there were advantages for RAPN in the subdomains of ‘Pain’ (P = 0.006) and ‘Physical functioning’ (P = 0.011) immediately after surgery. For the European Organisation for Research and Treatment of Cancer quality of life questionnaire 30‐item core there were overall advantages directly after surgery (mean [sd] score OPN 63 [20] vs RAPN 75 [17], P = 0.031), as well as for the subdomains ‘Fatigue’ (P = 0.026), ‘Pain’ (P = 0.002) and ‘Constipation’ (P = 0.045) but no differences at POD90. There were no differences for the EuroQoL five Dimensions five Levels questionnaire at POD90 (mean [sd] score OPN 70 [22] vs RAPN 72 [17], P = 1.0) or at any other time point. Finally, no significant differences were found for the overall Convalescence and Recovery Evaluation questionnaire score at POD90 (mean [sd] OPN 84 [13] vs RAPN 86 [10], P = 0.818) but less pain in the RAPN group (P = 0.017) directly after surgery.ConclusionsPain and physical functioning as subdomains of QoL are improved after RAPN compared to OPN in the early postoperative course, while there are no differences anymore after 3 months.
Early identification of postoperative remission for thyrotropin‐secreting adenomas
Authors: Fan Linling , Wang Zhihong , Sun Wanwan , Cui Qiaoli , Wu Wei , Xiang Boni , Ma Zengyi , Wu Yue , Wang Yongfei , Zhang Zhaoyun , Li Yiming , He Min , Ye Hongying 
Published: May 2024

AbstractObjectiveThyrotropin‐secreting adenoma (TSHoma) is a rare type of pituitary adenoma, occurring in one per million people. Little is known about TSHoma. We summarized the demographic, clinical and hormonal characteristics of TSHoma based on a single‐centre experience. Moreover, we explored the predictive value of postoperative thyroid function for long‐term remission.Design, Patients and MeasurementsWe retrospectively analysed 63 patients who were diagnosed as TSHoma and surgically treated at our hospital from January 2015 to June 2021. The preoperative clinical characteristics were analysed and compared between remission and nonremission groups. Thyroid function was measured at 1 day, 1 month, 3 months, 6 months, 12 months and over 12 months after surgery to determine whether they could predict long‐term remission.ResultsThe male to female ratio for TSHoma was 1.25. The mean age at diagnosis was 45 ± 12 years. Clinical presentation was varied, presenting with hyperthyroidism (68.25%), space‐occupying effect (15.87%), amenorrhea (7.14% of female patients) and nonsymptoms (22.22%). 88.14% of patients achieved postoperative endocrinological remission. Larger tumour size and tumour invasion into cavernous sinus and suprasellar with chiasmal compression were strong predictors of lower rates of endocrinological remission. Postoperative thyroid function at 3 months was a viable diagnostic predictor for postoperative remission, especially for FT4 level with a 20.65 pmol/L cutoff.ConclusionsTumour size and extent are major prognostic factors for remission. Postoperative thyroid function at 3 months could be used as a clinical prediction tool for long‐term endocrinological remission.
Characteristics of and foundation application among Chinese females with sensitive skin
Authors: Kuang Xinjue , Cai Jiajing , Li Yingqi , Yang Xiaoxiao , Zi Huimin , Wang Feifei , Yi Fan 
Published: May 2024

AbstractObjectiveWe conducted a study on women with sensitive skin of various skin tones to analyse their skin characteristics and preferences for foundation shades.MethodsVolunteers were categorized based on their individual typological angle, and their preferences were assessed using self‐perception and software‐based mass aesthetic assessment. The Baumann Questionnaire is a valuable tool for identifying patients with sensitive skin and gaining a comprehensive understanding of their skin sensitivity. The skin characteristics of two groups were compared using a more suitable classification method.ResultsIndividuals diagnosed with sensitive skin typically have skin tones classified as Types I, II and III, with Type I being the most common in sensitive skin cases. The sensitive group exhibited higher levels of transepidermal water loss, lighter skin tone, lower yellowness, increased glossiness, higher haemoglobin content, more acne, fewer blackheads, and fewer pores. Among them, Type I skin is characterized by lower elasticity, increased oiliness, higher hydration levels and fewer visible pores. Type II skin is characterized by lower hydration levels, higher oiliness and increased redness. Type III exhibits more pores, decreased oiliness and enhanced elasticity. Foundations No. 2 and No. 3 are fairer than foundations No. 1 and No. 4. In the self‐assessment, Type I and Type II subjects preferred No. 3, while Type III subjects preferred No. 1 and No. 4 because they matched their skin tone. The results of the software evaluation showed that popular aesthetics preferred Type I and Type II to use No. 2, and Type III to use No. 2 and No. 3, as they resulted in a fairer complexion.ConclusionSensitive skin of different skin tone types confronts different skin problems. The findings also highlight the public's inclination towards lighter foundation shades, despite the common practice of selecting shades that harmonize with one's inherent skin tone.
Allergens grouping names on packaging: Are the substances similar enough to ensure safety? The worst case scenarios question this
Authors: Vandamme C. , Guillaume M. , Pirnay S. 
Published: May 2024

AbstractObjectiveEuropean Commission Regulation (EU) n°2023/1545 introduced the concept of grouping names in the cosmetics sector in July 2023. These groups bring together allergenic substances with the same level of skin sensitization. Their purpose is to lighten the list of ingredients on cosmetic packaging, by grouping together substances deemed to be similar under the same name. As this classification is based on a single toxic effect − skin sensitization − the present study aims to analyse the relevance of these groupings with regard to other toxic effects of substances in the same group.MethodsThis study was carried out by consulting an available database, various reports from 5 committees, 2 books and 5 articles in order to complete the toxicological profile of each substance. Then, in order to highlight any discrepancies within the classification, the worst cases were identified. For this purpose, the data for each substance in a group were compared, and in the event of greater criticality for a toxic effect, this was qualified as a worst case. In addition, similar toxic effects between several substances within the same group were also recorded. The aim of this additional research was to validate the definition of the grouping name and the similarities between substances in the same group.ResultsFrom the 17 grouping names, 5 presented worst cases. Two groups had 2 worst cases and the others only one. In total, from the 7 worst cases detected, 3 were due to the toxic effect “skin irritation”. In most cases, the substances in the groupings shared the presence or absence of risk. Only the degree of risk criticality varied.ConclusionClassification by grouping names appears justified regarding the similarities between substances, particularly in terms of skin sensitization. However, the presence of worst cases qualifies it and highlights the importance of being vigilant when assessing the risk of cosmetic products including these grouping names in their list of ingredients.
Unsettling Environmentalism
Authors: Zachariah George 
Published: May 2024

AbstractDecolonial ecological imaginations entail a critical interrogation of mainstream environmentalism to unmask and unsettle it. These reflections expose how mainstream environmentalism legitimizes and perpetuates the colonization of the Earth and subaltern and Indigenous communities. Mainstream environmentalism is a colonial project to perpetuate the interests of settler colonialism and racial capitalism. This calls for a new search for decolonial and alternative ecological reimagination, informed by the epistemologies and eco‐politics of the Indigenous and subaltern communities and other grassroots social movements. Decolonial ecological imaginations involve the task of contesting and unsettling settler colonialism, extractive/exploitative capitalism, white supremacy, and all ideologies and practices of domination and exclusion.
Discipleship in Contemporary Mission
Authors: Tulak Semuel 
Published: May 2024

AbstractThis article explores the concept and practice of discipleship in contemporary missions. Discipleship in mission reflection has emerged in recent years within the scope of the World Council of Churches and the Asian Christian Conference. The practice of intentional discipleship is carried out not only by churches or parachurches but also by communities of Jesus followers who adhere to non‐Christian religions. They remained in their religion but professed to believe in and accept Jesus Christ as their Lord and Saviour. They study individually or together in a community to grow in the proper knowledge of Christ and know what God wants them to do in their daily lives. This article presents several case examples, mainly from Indonesia, resulting from the author's research.
A Decolonial Syncretism of Unity
Authors: Green Michael 
Published: May 2024

AbstractThe term syncretism has had a metamorphic history in terms of its meaning, starting as positive with Plutarch, to being positive and negative during the Reformation, and then becoming neutral and negative after the Reformation to becoming decidedly negative from the 1920s onward. Despite advances in interpreting syncretism in more neutral or positive ways, the word's meaning and function remain imprecise. Central to the fog surrounding the word is its implicit meaning of some type of mixture, whether negative, neutral, or positive. The question then becomes, “Is mixture a valid central meaning of the word?” More importantly, can the suspicious lens of decolonialism offer insight into redefining it and also give direction as to how it could function? This article studies the development of the term, examines current scholarship within the World Council of Churches, and situates syncretism within the larger context of the decolonial discussion in trying to redefine it in light of its original meaning.
The impact of a patient‐centred care pathway for patients treated with oral anticancer drugs: A multicentre pre−posttest study in Flanders
Authors: Kenis Ilyse , Van Hecke Ann , Foulon Veerle 
Published: May 2024

AbstractRationaleIn the Collaborative Network To Take Responsibility for Oral Anticancer Therapy (CONTACT) project, an evidence‐based and patient‐centred care(PCC) pathway was implemented in 12 oncology departments in Flanders. The care pathway was developed in cocreation by an interdisciplinary project team, and tailored to the local hospital context.Aims and ObjectivesIn this study, the impact of the care pathways on quality of PCC and other patient outcomes was investigated.MethodA pre−posttest study was performed in nine of the participating oncology departments. The primary outcome was quality of PCC. Furthermore, level of patient self‐management, medication adherence, satisfaction with information about the oral anticancer drug and quality of life were measured as secondary outcomes. Linear mixed models were used to investigate differences in outcomes between the pre‐ and posttest group.ResultsQuality of PCC, as well as all secondary outcomes improved after implementation of the care pathway. However, the changes in pre‐ and posttest scores were not significant. The overall quality of PCC increased from 3.72 to 3.88, measured on a five‐point Likert scale (p = 0.124).ConclusionThis study showed small, however, no significant improvements in the quality of PCC and other patient outcomes. The lack of significant changes can be attributed to the complexity of the care pathway development, poor or unstable implementation of the care pathway and limited changes in follow‐up care. More insight in the actual implementation of the care pathway and potential contextual factors influencing its effect is needed to help understand the outcomes of this pre−posttest study.
A low baseline serum myostatin concentration is associated with poor clinical outcome in patients with primary biliary cholangitis
Authors: Hayashi Manabu , Abe Kazumichi , Sugaya Tatsuro , Takahata Yosuke , Fujita Masashi , Takahashi Atsushi , Ohira Hiromasa 
Published: May 2024

AbstractBackground and AimPrimary biliary cholangitis (PBC) is an autoimmune‐mediated cholestatic liver disease that can progress to biliary cirrhosis and liver‐related death. The associations between baseline myostatin levels and clinical outcomes in PBC patients are unknown. We aimed to clarify the influence of myostatin levels on the clinical outcomes of PBC patients.MethodsA total of 119 PBC patients were analyzed in this study. Myostatin levels were measured in stored sera before ursodeoxycholic acid treatment, and their associations with the clinical features and prognosis of PBC patients were analyzed. We analyzed the correlation between serum myostatin and chemokines/cytokines.ResultsSerum myostatin was significantly lower in PBC patients (2343 pg/mL) than in healthy controls (4059 pg/mL, P < 0.001). The prevalence of patients with low myostatin levels increased according to the severity of histological fibrosis. The serum myostatin concentration was negatively correlated with the IL‐6 and leucine‐rich α2 glycoprotein levels, but the chemokine concentration was not correlated with the myostatin concentration. Low myostatin in PBC patients was associated with shorter survival without liver‐related complications (hazard ratio [HR], 3.598; 95% confidence interval [CI], 1.27–10.1; P = 0.015) and shorter transplant‐free survival (HR, 3.129; 95% CI, 1.02–9.56; P = 0.045) independent of pretreatment GLOBE score. Patients with both high pretreatment GLOBE scores and low myostatin levels had poor prognoses (log–rank test: P < 0.001).ConclusionsA low serum myostatin concentration at diagnosis was associated with poor clinical outcomes. Assessment of circulating myostatin levels may improve the prediction of outcomes in patients with PBC.
Clear cell hidradenoma of the breast with MAML2 gene rearrangement
Authors: Luo Li , Hu Yanping 
Published: May 2024

AbstractClear cell hidradenoma is a rare benign tumor of the breast, its origin and pathogenesis are controversial. We have experienced a case of breast clear cell hidradenoma with mastermind like transcriptional coactivator 2 (MAML2) gene rearrangement. The patient found a painless mass with a hard texture in the left breast areola without nipple discharge. Microscopically, the tumor was cystic and solid, locally arranged in a glandular structure, covered by single cuboidal cells; it was composed of clear cells, epidermoid cells, and basaloid cells; there were no necrosis or mitotic figures. Immunohistochemical staining showed that the tumor cells positively expressed low‐molecular cytokeratin 7, low‐molecular cytokeratins (Cam5.2), high‐molecular cytokeratin 5/6, cytokeratin 14, CD117, and p63; and did not express calponin, and smooth muscle myosin heavy chain. The cuboidal cells were positive for SOX10 but negative for p63. Additionally, periodic acid‐Schiff reaction showed purple‐red granules in the tumor cytoplasm, but Alcian blue staining showed no blue mucus in the cytoplasm. The split signals of MAML2 gene were detected by fluorescence in situ hybridization. Subtle histological and immunophenotypical differences may help to distinguish breast clear cell hidradenoma from common breast tumors. Furthermore, the MAML2 gene rearrangement may be a molecular genetic characteristic of breast clear cell hidradenoma.
Soil property differences and irrigated‐cotton lint yield—Cause and effect? An on‐farm case study across three cotton‐growing regions in Australia
Authors: Nachimuthu Gunasekhar , Palmer Blake , Hundt Andy , Schwenke Graeme , Jamali Hiz , Knox Oliver , Guppy Chris 
Published: May 2024

AbstractThe average lint yield of irrigated cotton in Australia ranges from 2270 to 3700 kg/ha, but yields vary substantially between farms and also between fields on the same farm. Differences in soil properties may cause these yield variations. Identifying which factors are causal and what management can be implemented to mitigate the impacts should help optimize inputs and improve profits. During the 2018–2019 summer cotton‐growing season, a paired‐field comparison approach was used to investigate and improve the understanding of soil property‐induced irrigated cotton yield differences within five farms across three regions of NSW, Australia. The paired fields at each farm recorded an average lint yield difference of >284 kg/ha (measured in 2018–2019 or 5‐year average lint yield). Several soil properties differed between the paired fields at each farm comparison. The soil organic carbon stocks were higher in the higher‐yielding fields at all the farm comparisons and the normalized lint yield percentage was positively correlated with soil organic carbon stocks. Soil sodicity was higher in the lower‐yielding fields at 3 of the 5 comparisons. Results for most soil nutrient tests were above the recommended critical concentrations for Australian cotton production. A stepwise linear regression excluding soil nutrients that were above soil test critical values for crop response and below crop toxicity levels indicated the lint yield was positively correlated with SOC stocks and negatively correlated with sodicity and bulk density. No earthworms were detected during visual soil assessment or soil sampling across all the sites. Visual soil assessment was not a sensitive predictor of cotton crop performance. Comparing soil properties using a paired field approach may assist cotton growers in understanding the factors behind yield differences. A similar strip comparison approach could be adopted for within‐field variability by dividing the fields into discrete performance zones and assessing the soil properties of each zone separately.
Mesoproterozoic Belt basin transect from Rogers Pass, Montana, to Sandpoint, Idaho, USA: Constraints for Proterozoic supercontinents and geomagnetism
Authors: Sears* James W. , Parker Stuart 
Published: May 2024

ABSTRACT
This field trip will test global tectonic models against detailed geologic and paleomagnetic data from within the Belt basin, and will evaluate the significance of its Neoproterozoic to early Cambrian rift truncation. The trip will focus on the stratigraphy and paleotectonic evolution of the Mesoproterozoic Belt basin on an E-W transect from the shallow-water facies of the east margin of the basin at Rogers Pass through its deep-water interior near Sandpoint, Idaho, USA. With some variations, this trip will follow Don Winston’s classic trans-basin field guide from the east edge of the basin at Rogers Pass, Montana, to its western rift-truncation near Sandpoint, along Montana Highway 200 and Interstate 90 along the Lewis and Clark Line.
O advento da Terapia Ocupacional no meio hospitalar. O caso da França
Authors: Goubert Jean-Pierre 
Published: May 2024

This article introduces the first founds of the research about the history of the occupational therapy in France. It deals about the analytical description of the former and initial conditions of the creation of the profession, as well as a panoramic view of the evolution of the Occupational Therapy until our days. The research methodology utilized is historical and the final aim of the research is the construction of a comparison between the Histories of the Occupational Therapy in Brazil and in France.