bluuebunny/crossref_metadata_2025_split huggingface dataset:
Occurrence and characterization of Pain in immune‐mediated neuropathies: a multicentre prospective study
Authors: Pazzaglia C. , Briani C. , Orazio E. N. , Caliandro P. , Granata G. , Tonali P. A. , Padua L. 
Published: June 2010

Background:  Pain is a common symptom of peripheral neuropathies that may severely affect patients’ Quality of Life. Pain questionnaires, based on verbal descriptors, are a useful way to investigate it.Methods:  We performed a multicentre study through validated measures to characterize pain in a sample of consecutive patients affected by immune‐mediated neuropathies.Results:  Ninety‐three patients were enrolled in 16 Italian centres. Based on the numeric rating scale, almost half of the patients complained of moderate pain and one‐third of the patients severe pain. Overall, up to 50% of our patients with immune‐mediated neuropathies complained of neuropathic pain. The most common neuropathic symptoms were paraesthesia/dysesthesia and superficial spontaneous pain. Surprisingly, also patients with neuropathies commonly thought to be painless (such as multifocal motor neuropathy) reported discomfort and painful symptoms.Conclusions:  Pain questionnaires should be considered in the clinical evaluation of immune‐mediated neuropathies, also when evaluating therapy efficacy, because they may provide clinicians with useful information on painful symptoms and patients’ quality of life.
Early microglial colonization of the human forebrain and possible involvement in periventricular white‐matter injury of preterm infants
Authors: Verney Catherine , Monier Anne , Fallet‐Bianco Catherine , Gressens Pierre 
Published: June 2010

AbstractAmoeboid microglial subpopulations visualized by antibodies against ionized calcium‐binding adapter molecule 1, CD68, and CD45 enter the forebrain starting at 4.5 postovulatory or gestational weeks (gw). They penetrate the telencephalon and diencephalon via the meninges, choroid plexus, and ventricular zone. Early colonization by amoeboid microglia–macrophages is first restricted to the white matter, where these cells migrate and accumulate in patches at the junctions of white‐matter pathways, such as the three junctions that the internal capsule makes with the thalamocortical projection, external capsule and cerebral peduncle, respectively. In the cerebral cortex anlage, migration is mainly radial and tangential towards the immature white matter, subplate layer, and cortical plate, whereas pial cells populate the prospective layer I. A second wave of microglial cells penetrates the brain via the vascular route at about 12–13 gw and remains confined to the white matter. Two main findings deserve emphasis. First, microglia accumulate at 10–12 gw at the cortical plate–subplate junction, where the first synapses are detected. Second, microglia accumulate in restricted laminar bands, most notably around 19–30 gw, at the axonal crossroads in the white matter (semiovale centre) rostrally, extending caudally in the immature white matter to the visual radiations. This accumulation of proliferating microglia is located at the site of white‐matter injury in premature neonates. The spatiotemporal organization of microglia in the immature white and grey matter suggests that these cells may play active roles in developmental processes such as axonal guidance, synaptogenesis, and neurodevelopmental apoptosis as well as in injuries to the developing brain, in particular in the periventricular white‐matter injury of preterm infants.
High fat diet increases hippocampal oxidative stress and cognitive impairment in aged mice: implications for decreased Nrf2 signaling
Authors: Morrison Christopher D. , Pistell Paul J. , Ingram Donald K. , Johnson William D. , Liu Ying , Fernandez‐Kim Sun Ok , White Christy L. , Purpera Megan N. , Uranga Romina M. , Bruce‐Keller Annadora J. , Keller Jeffrey N. 
Published: June 2010

J. Neurochem. (2010) 114, 1581–1589.AbstractLong term consumption of a high fat diet (HFD) contributes to increased morbidity and mortality. Yet the specific effects of HFD consumption on brain aging are poorly understood. In the present study 20‐month old male C57Bl/6 mice were fed either ‘western diet’ (41% fat), very high fat lard diet (60% fat), or corresponding control diets for 16 weeks and then assessed for changes in metabolism and brain homeostasis. Although both HFDs increased adiposity and fasting blood glucose, only the high fat lard diet increased age‐related oxidative damage (protein carbonyls) and impaired retention in the behavioral test. This selective increase in oxidative damage and cognitive decline was also associated with a decline in NF‐E2‐related factor 2 (Nrf2) levels and Nrf2 activity, suggesting a potential role for decreased antioxidant response. Taken together, these data suggest that while adiposity and insulin resistance following HFD consumption are linked to increased morbidity, the relationship between these factors and brain homeostasis during aging is not a linear relationship. More specifically, these data implicate impaired Nrf2 signaling and increased cerebral oxidative stress as mechanisms underlying HFD‐induced declines in cognitive performance in the aged brain.
RISK PREMIUM EFFECTS ON IMPLIED VOLATILITY REGRESSIONS
Authors: Rompolis Leonidas S. , Tzavalis Elias 
Published: June 2010

AbstractThis article provides new insights into the sources of bias of option implied volatility to forecast its physical counterpart. We argue that this bias can be attributed to volatility risk premium effects. The latter are found to depend on high‐order cumulants of the risk‐neutral density. These cumulants capture the risk‐averse behavior of investors in the stock and option markets for bearing the investment risk that is reflected in the deviations of the implied risk‐neutral distribution from the normal distribution. We show that the bias of implied volatility to forecast its corresponding physical measure can be eliminated when the implied volatility regressions are adjusted for risk premium effects. The latter are captured mainly by the third‐order risk‐neutral cumulant. We also show that a substantial reduction of higher order risk‐neutral cumulants biases to predict their corresponding physical cumulants is supported when adjustments for risk premium effects are made.
Jiselle and the Royal Jelly: Power, Conflict and Culture in an Interdisciplinary Game Design Course
Authors: Dickey Michele D. 
Published: June 2010

AbstractWith the rising popularity of digital games, a growing number of universities are developing programmes in various areas of digital design and interactive media to meet the needs for game‐related courses. Faculty of this emerging field are grappling with the complexity of developing curricula which integrate art, design and technology and of finding methods of integrating students from these diverse fields. The purpose of this article is to present a case study of an interdisciplinary undergraduate course in game design and to highlight some of the unforeseen challenges and issues that arose when attempting to integrate diverse students from various art, design and media fields with students from computer science. Specifically, this article addresses issues of (a) power, (b) conflict and (c) gender that arose among students during the development of a student‐created game.
What is the Relationship between Social Tact in Teacher–Pupil Exchanges and Creativity? Reconceptualising Functional Causes of Creativity in Artmaking
Authors: Thomas Kerry 
Published: June 2010

AbstractArt teachers are renowned for their claims that the creative properties of their senior secondary pupils' artworks occur as a result of the realisation of a creative process. Drawing on my recent ethnographic studies in senior art classrooms in Sydney, Australia, and Illinois, USA, I uncover a sociological, rather than a psychological explanation of creativity, which ironically, appears to satisfy the creative process claims of teachers. This article reveals how social tact in teacher–pupil exchanges has a function in bolstering the quality of the pupils' performances and their artworks while repressing the teacher's pedagogical role. The design and methodologies of the studies are outlined and two grounded narratives characterise cases of social tact between art teachers and pupils. A brief account is provided on the socio‐cultural framework of these studies, informed by Bourdieu's theories of the habitus, symbolic capital and misrecognition. Bourdieu's theories offer a robust conceptual apparatus which helps to explain how the sociality of classroom exchanges, with all of their ambiguities in practice, are a necessity in the realisation of creative ends.
Explorations in Teaching Sustainable Design: A Studio Experience in Interior Design/Architecture
Authors: Gürel Meltem Ö. 
Published: June 2010

AbstractThis article argues that a design studio can be a dynamic medium to explore the creative potential of the complexity of sustainability from its technological to social ends. The study seeks to determine the impact of an interior design/architecture studio experience that was initiated to teach diverse meanings of sustainability and to engage the participants with refined design applications that used sustainable choices. A teaching scheme that utilised a team of instructors with varying degrees of knowledge and competence in different aspects of the topic, mediated the education of both the students and the instructors themselves. The results were documented through observing the students and, later, a survey of the graduates. The study revealed that this studio experience developed a heightened awareness of sustainability as a multidimensional concept that requires critical thought processes, and greatly influenced the recognition of environmentally responsible design as an imperative in education. The findings also suggested that, ideally, sustainability should be addressed earlier, at lower levels, and needs to be woven into every aspect of a curriculum.
Seeing History: Malaika Favorite's Furious Flower Poetry Quilt Painting and Pan‐African Memory
Authors: Shanahan Maureen G. 
Published: June 2010

AbstractMalaika Favorite's Furious Flower Poetry Quilt (2004) is an acrylic painting that depicts 24 portraits of leading poets of the African Diaspora. Commissioned by Dr Joanne Gabbin, English professor and director of the Furious Flower Poetry Center at James Madison University, the painting is part of a larger programme of poetry education. The painting's interweaving of the portraits with fragments from the poets’ writing functions to create an interactive visual‐textual body of poets and poetry, a collection which has been taught at all levels of education from primary school to university. Its quilt structure pays homage to the historic role of women in preserving history and memory. The painting also serves to construct a pan‐African identity and collective memory about slavery, African American history and empowerment.
Recurrent respiratory papillomatosis: a complex defect in immune responsiveness to human papillomavirus‐6 and ‐11
Authors: BONAGURA VINCENT R. , HATAM LYNDA J. , ROSENTHAL DAVID W. , DE VOTI JAMES A. , LAM FUNG , STEINBERG BETTIE M. , ABRAMSON ALLAN L. 
Published: June 2010

Bonagura VR, Hatam LJ, Rosenthal DW, DeVoti JA, Lam F, Steinberg BM, Abramson AL. Recurrent respiratory papillomatosis: a complex defect in immune responsiveness to human papillomavirus‐6 and ‐11. APMIS 2010; 118: 455–470.Recurrent respiratory papillomatosis (RRP) is a rare disease of the larynx caused by infection with human papillomaviruses (HPV) ‐6 or ‐11, associated with significant morbidity and on occasion mortality. Here we summarize our current understanding of the permissive adaptive and innate responses made by patients with RRP that support chronic HPV infection and prevent immune clearance of these viruses. Furthermore, we provide new evidence of TH2‐like polarization in papillomas and blood of patients with RRP, restricted CD4 and CD8 Vβ repertoires, the effect of HPV‐11 early protein E6 on T‐cell alloreactivity, enriched Langerhans cell presence in papillomas, and evidence that natural killer cells are dysfunctional in RRP. We review the immunogenetic mechanisms that regulate the dysfunctional responses made by patients with RRP in response to HPV infection of the upper airway. In addition, we are identifying T‐cell epitopes on HPV‐11 early proteins, in the context of human leukocyte antigen (HLA) class II alleles enriched in RRP that should help generate a therapeutic vaccine. Taken together, RRP is a complex, multigene disease manifesting as a tissue and HPV‐specific, immune deficiency that prevents effective clearance and/or control of HPV‐6 and ‐11 infection.
Interaction of viral oncoproteins with cellular target molecules: infection with high‐risk vs low‐risk human papillomaviruses
Authors: PIM DAVID , BANKS LAWRENCE 
Published: June 2010

Pim D, Banks L. Interaction of viral oncoproteins with cellular target molecules: infection with high‐risk vs low‐risk human papillomaviruses. APMIS 2010; 118: 471–493.Persistent infection by a subgroup of so‐called high‐risk human papillomaviruses (HPVs) that have a tropism for mucosal epithelia has been defined as the cause of more than 98% of cervical carcinomas as well as a high proportion of other cancers of the anogenital region. Infection of squamous epithelial tissues in the head and neck region by these same high‐risk HPVs is also associated with a subset of cancers. Despite the general conservation of genetic structure amongst all HPV types, infection by the low‐risk types, whether in genital or head and neck sites, carries a negligible risk of malignant progression, and infections have a markedly different pathology. In this review, we will examine and discuss the interactions that the principal viral oncoproteins of the high‐risk mucosotrophic HPVs and their counterparts from the low‐risk group make with cellular target proteins, with a view to explaining the differences in their respective pathology.
Epidemiology of recurrent respiratory papillomatosis
Authors: LARSON DANIEL A. , DERKAY CRAIG S. 
Published: June 2010

Larson DA, Derkay CS. Epidemiology of recurrent respiratory papillomatosis. APMIS 2010; 118: 450–454.Recurrent respiratory papillomatosis (RRP) was first described in the 1800s, but it was not until the 1980s when it was convincingly attributed to human papilloma virus (HPV). RRP is categorized into juvenile onset and adult onset depending on presentation before or after the age of 12 years, respectively. The prevalence of this disease is likely variable depending on the age of presentation, country and socioeconomic status of the population being studied, but is generally accepted to be between 1 and 4 per 100 000. Despite the low prevalence, the economic burden of RRP is high given the multiple procedures required by patients. Multiple studies have shown that the most likely route of transmission of HPV in RRP is from mother to child during labor. Exceptions to this may include patients with congenital RRP who have been exposed in utero and adult patients who may have been exposed during sexual contact. Although cesarean section may prevent the exposure of children to the HPV virus during childbirth, its effectiveness in preventing RRP is debatable and the procedure itself carries an increased risk of complications. The quadrivalent HPV vaccine holds the most promise for the prevention of RRP by eliminating the maternal reservoir for HPV.
Cynomolgus monkeys (Macaca fascicularis) may not become infected with equine herpesvirus 9
Authors: Kodama Atsushi , Yanai Tokuma , Kubo Masahito , El‐Habashi Nagwan , Kasem Samy , Sakai Hiroki , Masegi Toshiaki , Fukushi Hideto , Kuraishi Takeshi , Yoneda Misako , Hattori Shosaku , Kai Chieko 
Published: June 2010

AbstractBackground  It was suggested that Equine herpesvirus 9 (EHV‐9) could be transmitted to higher non‐human primates.Methods  Four cynomolgus monkeys (Macaca fascicularis) were inoculated with EHV‐9 by the nasal route.Results  No abnormalities were observed pathologically, immunohistochemically, and genetically.Conclusions  These findings indicate that cynomolgus monkeys are not susceptible to EHV‐9.
Period‐four Modulation of Photosystem II Primary Quinone Acceptor (QA) Reduction/Oxidation Kinetics in Thylakoid Membranes
Authors: Gauthier Alain , Joly David , Boisvert Steve , Carpentier Robert 
Published: June 2010

AbstractPhotosystem II (PSII), a multiprotein complex mainly coded by the chloroplast genome in higher plants and algae, contains the oxygen‐evolving complex with four manganese atoms responsible for the oxidation of water. After each absorption of a light quantum by pigment molecules in the light harvesting complexes of PSII, the Mn cluster advances in its oxidation states denoted from S0 to S4. The S4 state decays to S0 in the dark with the concurrent release of molecular oxygen. Therefore, the oxygen production in PSII exposed to successive single turnover excitations follows a period‐four oscillation pattern. The intensity of chlorophyll a fluorescence of PSII is also known to be influenced by the oxidation state of the Mn cluster. In the present work, fluorescence induction kinetics was measured in isolated thylakoids with various initial S‐state populations settled by preflashes. The shape of the fluorescence induction traces was strongly affected by preflashes. O‐J and J‐I phases of the induction followed a period‐four oscillation pattern. The results indicate that these changes reflect the influence of the oxidation rate of the Mn cluster on the reduction/oxidation kinetics of the primary quinone acceptor (QA) of PSII.
Relapses after surgical treatment of ocular adnexal basal cell carcinomas: 5‐year follow‐up at the same university centre
Authors: Bertelmann Eckart , Rieck Peter 
Published: June 2010

Abstract.Purpose:  To define the efficacy of surgical resection of ocular adnexal basal cell carcinoma and to analyse possible risk factors, we determined relapse rates on a yearly basis postintervention in a cohort of patients that were treated in our hospital under comparable conditions.Methods:  A total of 366 such cases that were admitted for treatment between 2002 and 2006 were followed prospectively once yearly and tumour size and localization, histological type, functional and cosmetical outcome and relapses were recorded. In cases when the primary resection margins were not free, further resections were performed until the resection margin was histologically assessed tumour free on the basis of paraffin‐fixed tissue sections. Lid reconstruction was carried out as direct closure, Tenzel rotation flap, tarsomarginal transplants or tarsoconjunctival flaps (Hughes), inversed rotation flaps, tarso marginal grafts, Cutler Beard flaps, free skin grafts, rhomboid, glabella or advancement flaps. Relapse‐free survival 3, 4 and 5 years postoperatively was estimated by the Kaplan–Meyer method.Results:  Three relapses after 3 years and two further relapses after 5 years were recorded. An additional relapse was documented 6 years postoperatively. Accordingly, the relapse‐free survival was 0.99 (95% CI 0.98–1.00) after 3 years, 0.99 (95% CI 0.97–1.00) after 4 years and 0.97 (95% 0.95–0.98) after 5 years. The relapses occurred in previously relapsed tumours and in tumours of morphea type. Primary nodular basal cell carcinomas did not relapse in this study.Conclusions:  Based on these studies and in comparison with published relapse rates after cryotherapy, surgical resection appears to be superior to the latter procedure.
An integrative modeling framework to evaluate the productivity and sustainability of biofuel crop production systems
Authors: ZHANG X. , IZAURRALDE R.C. , MANOWITZ D. , WEST T. O. , POST W. M. , THOMSON A. M. , BANDARU V. P. , NICHOLS J. , WILLIAMS J. R. 
Published: June 2010

AbstractThe potential expansion of biofuel production raises food, energy, and environmental challenges that require careful assessment of the impact of biofuel production on greenhouse gas (GHG) emissions, soil erosion, nutrient loading, and water quality. In this study, we describe a spatially explicit integrative modeling framework (SEIMF) to understand and quantify the environmental impacts of different biomass cropping systems. This SEIMF consists of three major components: (1) a geographic information system (GIS)‐based data analysis system to define spatial modeling units with resolution of 56 m to address spatial variability, (2) the biophysical and biogeochemical model Environmental Policy Integrated Climate (EPIC) applied in a spatially‐explicit way to predict biomass yield, GHG emissions, and other environmental impacts of different biofuel crops production systems, and (3) an evolutionary multiobjective optimization algorithm for exploring the trade‐offs between biofuel energy production and unintended ecosystem‐service responses. Simple examples illustrate the major functions of the SEIMF when applied to a nine‐county Regional Intensive Modeling Area (RIMA) in SW Michigan to (1) simulate biofuel crop production, (2) compare impacts of management practices and local ecosystem settings, and (3) optimize the spatial configuration of different biofuel production systems by balancing energy production and other ecosystem‐service variables. Potential applications of the SEIMF to support life cycle analysis and provide information on biodiversity evaluation and marginal‐land identification are also discussed. The SEIMF developed in this study is expected to provide a useful tool for scientists and decision makers to understand sustainability issues associated with the production of biofuels at local, regional, and national scales.
The effects of organic and inorganic fertilizer applications to Miscanthus×giganteus, Arundo donax and Phalaris arundinacea, when grown as energy crops in Wales, UK
Authors: SMITH R. , SLATER F. M. 
Published: June 2010

AbstractTwo pot trials and one field trial were established to investigate the effects of organic and inorganic fertilizer applications to energy crops grown in mid‐Wales. Chicken litter and sewage cake applied at a high level in excess of MAFF recommendations produced an increased yield response in Miscanthus and Arundo plants. Miscanthus plants exhibited an increased growth response to all fertilizers applied in its second year. Fertilizer applications in accordance with MAFF recommendations produced no significant differences in yields for Miscanthus or Arundo potted plants. In the field there was an increased yield response of Miscanthus to inorganic nitrogen applications compared with organic manures, but not with control plots. Analysis of the Miscanthus plant material at harvest showed significant differences in the nitrogen, potassium and copper content between treatments. No mineral content differences were shown for Miscanthus rhizome material or Arundo plant material. The Phalaris plants did not exhibit significant differences in growth or yield parameters, but their plant matter showed differences in nitrogen, phosphorus, potassium, calcium, sulphur and boron content between treatments.