bluuebunny/crossref_metadata_2025_split huggingface dataset:
259 DEVELOPMENT OF AN ONTOLOGY FOR LAPAROSCOPIC TRANSABDOMINAL ADRENALECTOMY FOR SURGICAL TRAINING AND VIDEO ANALYSIS WITH MACHINE LEARNING ALGORITHMS AND ITS VALIDATION VIA A COMPREHENSIVE MODIFIED DELPHI SURVEY
Authors: Di Lorenzo S , Seeliger Barbara , Francesco A P , Brunaud L , Chiapponi C , De Crea C , Donatini G , Iacobone M , Makay Ö , Mihai R , Mogl M , Mutter D , Padoy N , Palazzo F , Vidal O , Vix M , Raffaelli M 
Published: May 2024

Abstract

Background
Although the safety of laparoscopic transabdominal lateral adrenalectomy (TLA) depends on the learning curve and experience of surgeons, surgical training remains a challenge as adrenalectomies are relatively rare. Structured laparoscopic video analysis supports individual training and could pave the way for automatic workflow recognition and safety alerts via Artificial Intelligence systems. We aimed to develop and validate a surgical ontology for TLA video analysis suitable for multicentric use.

Methods
An ontology hierarchically structured in phases and steps of laparoscopic right (RTLA) and left (LTLA) TLA was developed and submitted to a web-based survey via a 2-rounds modified Delphi process shared among 17 experienced adrenal surgeons across Europe. Consensus was defined at ≥ 80% agreement for each statement.

Results
RTLA was subdivided in 6 phases and 27 steps, and LTLA in 6 phases and 25 steps. Phases on both sides were: I) Preparation (5 statements), II) Exposition (8 statements), III) Dissection of the main adrenal vein (RTLA 14 statements, LTLA 12 statements), IV) Dissection of adrenal gland (6 statements), V) Extraction and disassembling (6 statements), and VI) any complementary intervention (1 statement). Panelist response rate was 88 % (15/17). Consensus was reached for LTLA in all 38 statements, and for RTLA in 39/40 statements (97,5%), as identification of the renal vein was not unanimously considered mandatory.

Conclusions
An expert consensus validated the developed ontology for TLA techniques as performed across Europe, suitable for multicentric video assessments and for surgical training and video analysis with machine learning algorithms.
98 A MULTIDISCIPLINARY TEAM - CENTRED ONE-STOP THYROID NODULE CLINIC REDUCES DELAY IN THYROID CANCER DIAGNOSIS AND MANAGEMENT – A SINGLE INSTITUTIONAL EXPERIENCE
Authors: Al Omar A , Oh H B , Ahmed A , Abdelsalam A , Garcia V , Kurzawinski T , Al-Lawati A , Pomplun S , Amin S , Gutierrez-Arniaz M , Monne F , Flynn D , Abdel-Aziz T 
Published: May 2024

Abstract

Background
Thyroid nodules are a common presentation in the surgical clinic. Patients are often referred by the GP under the 2-week wait rule in the UK. Majority of these nodules are benign but require an US scan and in many cases an US-FNAC. We launched the Multidisciplinary Team (MDT) one-stop clinic (OSC) in January 2022 to streamline services and improve patients’ experience.

Methods
Demographics, cytology reports and management plans of all patients who attended the OSC from January 2022-March 2023 were reviewed from the electronic medical records. Time to definitive surgery was also reviewed and patients were followed up for a minimum of 6 months.

Results
308 patients attended OSC (Females:251(81%), Males:57(19%)). 144(47%) were symptomatic while 164(53%) were incidental. 113(37%) had palpable thyroid nodules with only 7% having a family history of Thyroid Cancer. 144(47%) patients had thyroid nodules targeted for FNAC and 72(50%) patients were diagnosed with definite/suspected malignancy. 65(45%) patients with benign cytology had their results explained to them via telemedicine. All patients with malignant/indeterminate results were discussed in the same-day MDT with a median time to definitive/diagnostic surgery of 27 days. Of note, only 5% had a non-diagnostic (Thy1) result.

Conclusions
A comprehensive one-stop clinic reduces patient visits and delays in thyroid cancer diagnosis and management. In addition, 75% of patents were reassured that they do not have thyroid cancer with results discussed on the same day. To our knowledge, this is the first novel one-stop thyroid clinic with same-day cytology results, MDT review and counselling for management.
264 IMPROVING INTELLECT WITH PARATHYROIDECTOMY
Authors: Jovanovic M , Grujicic S S , Tausanovic K , Slijepcevic N , Rovcanin B , Stojanovic M , Odalovic B , Jovanovic K , Buzejic M , Ivanis S , Parezanovic M , Ilic J , Zivaljevic V 
Published: May 2024

Abstract

Background
Along with classic clinical symptoms and its negative effects on quality of life, primary hyperparathyroidism (pHPT) can influence cognitive status, as well. The aim of this study was to evaluate the cognitive status of patients with primary hyperparathyroidism before and after parathyroidectomy.

Methods
During a two-year period, a panel study was conducted at our institution, that included patients scheduled for parathyroidectomy. Basic demographic data of interest and relevant clinical data were collected. Cognitive status was assessed in interviews before surgery, one month, and six months following surgery using a Mini-Mental State Examination (MMSE).

Results
A total of 101 patients (88 females) with pHPT were included in the study, with an average age of 60.7 years. The average preoperative calcium and PTH levels were 2.98 mmol/L and 305.9 ng/mL, respectively. There was a significant improvement in MMSE score six months after parathyroidectomy (from 27.6 to 28.9, p&lt;0.001). Preoperatively, 9.9% of patients had a pathological MMSE score (≤25), and six months after parathyroidectomy, only one patient had the mild disorder. According to the univariable linear regression analysis, older age, lower level of education, unemployment and higher PTH level preoperatively were risk factors for lower MMSE score. Still, based on the multivariable linear regression analysis, only age over 61 was an independent predictor. The risk factor for greater change of MMSE score postoperatively was lower level of education.

Conclusions
A notable number of patients with primary hyperparathyroidism preoperatively show signs of impaired cognitive status, with substantial improvement after successful parathyroidectomy.
249 SURGICAL MANAGEMENT OF ZOLLINGER-ELLISON SYNDROME IN MULTIPLE ENDOCRINE NEOPLASIA TYPE 1, AN AFCE AND GTE COHORT STUDY. (ASSOCIATION FRANCOPHONE DE CHIRURGIE ENDOCRINIENNE AND GROUPE D'ÉTUDE DES TUMEURS ENDOCRINES)
Authors: Gaujoux S , Pattou F , Caiazzo R , Deguelte S , Donatini G , Lifante J C , Mirallié E , Santucci N , Sebag F , Goudet P 
Published: May 2024

Abstract

Background
Management of ZES in MEN1 remains controversial. The objective was to describe surgical indications, procedures and outcome in patients operated for Zollinger-Ellison syndrome (ZES) in Multiple Endocrine Neoplasia type 1 (MEN1) using a large nationwide cohort.

Methods
All patients with ZES diagnosed through the MEN1 AFCE/GTE network during the 1985-2015 period.

Results
Among 233 ZES patients, 66 (28%) were operated for ZES-related gastrinoma(s). Thirty-three (51%) procedures aimed at removing gastrinoma(s) and associated pancreatic neuroendocrine tumor(s) (pNET(s)) by appropriate resection(s). Thirty-two procedures (49%) aimed at removing gastrinoma(s) alone (ZES group). Survival was decreased in metastatic patients at ZES diagnosis (p&lt;0.001). Fifteen-year survival among non-metastatic patients was not significantly better in operated patients (82% (95% CI:67-90) versus 70% (95% CI:60-78)) (p=0.2). Operative mortality was nil. Metastatic lymph nodes were found in 30/42 lymphadenectomies (71%). The choice between duodenopancreatectomy versus duodenal focused surgery in the ZES group was associated with pre-operative detection of adenopathies (p&gt;0.001), leading to more frequent lymphadenectomies (p&lt;0.01). Previous pancreatic surgeries (30%) may have influenced the choice of ZES procedures.

Conclusions
The high rate of invaded nodes in lymphadenectomies in MEN1 patients operated for ZES, the absence of operative mortality, and the decreased survival in metastatic patients are indirect arguments for surgery. Duodenopancreatectomy was chosen more frequently than duodenal focused surgery in case of suspected lymph nodes in the ZES group. Duodenopancreatectomy may be indicated in young and fit patients to prevent metastatic evolution in the ZES group. Removing gastrinoma(s) when associated with large pNET(s) is justified.
Major surgical conditions of childhood and their lifelong implications: comprehensive review
Authors: Cullis Paul S , Fouad Dina , Goldstein Allan M , Wong Kenneth K Y , Boonthai Ampaipan , Lobos Pablo , Pakarinen Mikko P , Losty Paul D 
Published: May 2024

Abstract

Background
In recent decades, the survival of children with congenital anomalies and paediatric cancer has improved dramatically such that there has been a steady shift towards understanding their lifelong health outcomes. Paediatric surgeons will actively manage such conditions in childhood and adolescence, however, adult surgeons must later care for these ‘grown-ups’ in adulthood. This article aims to highlight some of those rare disorders encountered by paediatric surgeons requiring long-term follow-up, their management in childhood and their survivorship impact, in order that the adult specialist may be better equipped with skills and knowledge to manage these patients into adulthood.

Methods
A comprehensive literature review was performed to identify relevant publications. Research studies, review articles and guidelines were sought, focusing on the paediatric management and long-term outcomes of surgical conditions of childhood. The article has been written for adult surgeon readership.

Results
This article describes the aforementioned conditions, their management in childhood and their lifelong implications, including: oesophageal atresia, tracheo-oesophageal fistula, malrotation, short bowel syndrome, duodenal atresia, gastroschisis, exomphalos, choledochal malformations, biliary atresia, Hirschsprung disease, anorectal malformations, congenital diaphragmatic hernia, congenital lung lesions and paediatric cancer.

Conclusion
The increasing survivorship of children affected by surgical conditions will translate into a growing population of adults with lifelong conditions and specialist healthcare needs. The importance of transition from childhood to adulthood is becoming realized. It is hoped that this timely review will enthuse the readership to offer care for such vulnerable patients, and to collaborate with paediatric surgeons in providing successful and seamless transitional care.
Experiment and performance analysis of serpentine-shaped cantilever beam for pipeline vibration-based piezoelectric energy harvester prototype development
Authors: Mohd Fairuz Wan Nabila , Mohd Nawi Illani , Ahmad Mohamad Radzi , Kannan Ramani 
Published: May 2024

Abstract
Pipelines produce vibrations during fluid or gas transportation. These vibrations are less likely to cause structural failure as they exist with a small magnitude and can be harvested into useful energy. This paper presents a study on the piezoelectric energy-harvesting method converting mechanical energy from pipeline vibration into electrical energy. The performance of the serpentine-shaped piezoelectric cantilever beam was observed to check whether the design can produce the highest output voltage within the allowable vibration region of the pipeline from 10 to 300 Hz through finite element analysis using COMSOL Multiphysics software (Supplementary Material). In addition, this study investigates the energy-harvesting potential of the proposed design under real pipeline vibration conditions through a lab vibration test. The harvested energy output is evaluated based on various vibration frequencies and amplitudes, which gives an idea of the device and its performance under different operating conditions. The experiment result shows that the energy harvester produced an open-circuit voltage of 10.28–15.45 V with 1 g of vibration acceleration. The results of this research will contribute to the development of efficient piezoelectric energy harvesters adapted for pipeline environments.
Artificial intelligence algorithms and three-dimensional volumetric rendering for basal cell carcinoma detection and tumour depth assessment in reflectance confocal microscopy–optical coherence tomography images: a pilot study
Authors: Pan Alexander , de Carvalho Nathalie , Silva Luisa , Harris Ucalene , Dusza Stephen , Sahu Aditi , Kose Kivanc , Monnier Jilliana , Chen Chih-Shan , Jain Manu 
Published: May 2024

Abstract
The reflectance confocal microscopy (RCM)–optical coherence tomography (OCT) device has shown utility in detecting and assessing the depth of basal cell carcinoma (BCC) in vivo but is challenging for novices to interpret. Artificial intelligence (AI) applied to RCM-OCT could aid readers. We trained AI models, using OCT rasters of biopsy-confirmed BCC, to detect BCC, create three-dimensional rendering and automatically measure tumour depth. Trained AI models were applied to a separate test set containing rasters of BCC, benign lesions, and healthy skin. Blinded reader analysis and tumour depth correlation with histopathology were conducted. BCC detection improved from viewing OCT rasters only (sensitivity 73.3%, specificity 45.5%) to viewing rasters with AI-generated BCC rendering (sensitivity 86.7%, specificity 48.5%). A Pearson correlation r2 = 0.59 (P = 0.02) was achieved for the tumour depth measurement between AI and histological measured depths. Thus, addition of AI to the RCM-OCT device may expand its utility widely.
Topographic effect on body-wave polarization and near-surface wave speed estimation
Authors: Li Yuanshen , Park Sunyoung 
Published: May 2024

SUMMARY
This study examines the topographic effect on the body-wave polarization and, subsequently, on near-surface wave speed estimation. We first derive 3-D P- and S-wave polarization angles in the presence of ground tilt, where the angles are functions of the ground tilt orientation, the near-surface wave speeds and the incident wave direction. We find that S-wave polarization angle varies considerably (e.g. more than 100 per cent) when the incident angle is close to the critical angle. The counter-intuitive phenomenon for flat surface, that is, P-wave polarization being only sensitive to S but not P wave speeds, breaks down in the presence of ground tilt, and P-wave polarization becomes sensitive to both P and S wave speeds. Examining the differences in the inferred wave speeds with and without the flat-surface assumption reveals that bias in wave speed estimates is, in general, higher for smaller incident angles, for example, about 50 per cent or higher for a 15° ground tilt and near-vertical (&lt;5°) incidence. The effect on P wave speed estimates is also significant when the S-wave incident angle approaches the critical angle. In order to investigate the topographic effect on wave speed estimates inferred using teleseismic polarization data, we revisit the near-surface wave speed estimates at Hi-net stations from a previous study that did not account for the topography. Based on the ground tilt and strike angles measured for each Hi-net site at 300-m scale—which is found to be the most relevant scale—we constrain P and S wave speeds utilizing the P-wave polarization data. We find that P-wave polarization data alone can effectively constrain not only S but also P wave speeds, especially when the ground tilt is sufficiently large (e.g. &gt;5°). Furthermore, our additional test suggests that including S-wave polarization data with the tilt consideration will improve the near-surface wave speed estimates significantly compared to when the tilt effect is ignored.
Surface electrocardiogram f wave analysis in patients with atrial fibrillation undergoing thoracoscopic epicardial ablation
Authors: An Kang , Li Haojie , Yu Chunyu , Zheng Zhe 
Published: May 2024

Abstract

OBJECTIVES
To investigate the predictive values of surface electrocardiogram-derived parameters in patients with atrial fibrillation who underwent thoracoscopic epicardial ablation.

METHODS
The present study included 102 patients with atrial fibrillation who underwent thoracoscopic epicardial ablation and whose baseline 12-lead electrocardiograms were available. Frequency domain analysis was performed to calculate the electrocardiogram-derived parameters. Cox proportional hazards regression was used to identify predictive risk factors for postoperative recurrence.

RESULTS
At 36-month interval, the overall rate of freedom from atrial tachyarrhythmia without antiarrhythmic drugs was 58.5%. The results of the univariable and multivariable analyses showed that larger left atrial diameter (hazard ratio: 1.074, 95% confidence interval: 1.021–1.130, P = 0.006) was an independent risk factor for atrial fibrillation recurrence, while higher fibrillatory wave amplitude was a protective factor (hazard ratio: 0.292, 95% confidence interval: 0.157–0.542, P &lt; 0.001). The associations were clarified by the restricted cubic splines. The dominant frequency and organization index were not identified as statistically significant parameters.

CONCLUSIONS
The fibrillatory wave amplitude has the highest predictive value for atrial fibrillation recurrence in electrocardiogram-derived parameters. Together with left atrial diameter, it may help identify patients in whom thoracoscopic ablation is likely to be effective.
L
2-Maximal Functions on Graded Lie Groups
Authors: Cardona Duván 
Published: May 2024

Abstract
Bourgain in his seminal paper of 1986 about the analysis of maximal functions associated to convex bodies has estimated in a sharp way the $L^{2}$-operator norm of the maximal function associated to a kernel $K\in L^{1},$ with differentiable Fourier transform $\widehat{K}.$ We formulate the extension to Bourgain’s $L^{2}$-estimate in the setting of maximal functions on graded Lie groups. Our criterion is formulated in terms of the group Fourier transform of the kernel. We discuss the application of our main result to the $L^{p}$-boundedness of maximal functions on graded Lie groups.
Blockade of CCR5 and CXCR3 attenuates murine acute graft-versus-host disease through modulating donor-derived T-cell distribution and function
Authors: Tang Bo , Qin Chenchen , Liu Huihui , Miao Shengchao , Xue Chao , Wang Zhenhua , Zhang Yang , Dong Yujun , Liu Wei , Ren Hanyun 
Published: May 2024

Abstract
Lymphocyte trafficking via chemokine receptors such as C-C chemokine receptor 5 (CCR5) and CXCR3 plays a critical role in the pathogenesis of acute graft-versus-host disease (aGVHD). Our previous studies showed that the addition of CCR5 or CXCR3 antagonists could only slightly alleviate the development of aGVHD. Given the specificity of T lymphocytes bearing CXCR3 and CCR5, we investigated whether combined CCR5 and CXCR3 blockade could further attenuate murine aGVHD. A mouse model of aGVHD was established to assess the efficacy of CCR5 and/or CXCR3 blockade on the development of aGVHD. The distribution of lymphocytes was calculated by quantification of immunostaining cells. The immunomodulatory effect on T cells was assessed by evaluating T-cell proliferation, viability, and differentiation. Using the murine allogeneic hematopoietic stem cell transplantation model, we demonstrated that blockade of both CCR5 and CXCR3 could efficiently alleviate the development of aGVHD. Further investigation on the immune mechanisms for this prophylactic effect showed that more T cells were detained into secondary lymphoid organs (SLOs), which may lead to reduced infiltration of T cells into GVHD target organs. Our study also showed that T cells detained in SLOs dampened the activation, suppressed the polarization toward T helper type 1 (Th1) and T cytotoxic type 1 (Tc1) cells, and induced the production of Treg cells. These data suggest that concurrent blockade of CCR5 and CXCR3 attenuates murine aGVHD through modulating donor-derived T-cell distribution and function, and this might be applicable for aGVHD prophylaxis in clinical settings.
Call me Dr Ishmael: trends in electronic health record notes available at emergency department visits and admissions
Authors: Patterson Brian W , Hekman Daniel J , Liao Frank J , Hamedani Azita G , Shah Manish N , Afshar Majid 
Published: May 2024

Abstract

Objectives
Numerous studies have identified information overload as a key issue for electronic health records (EHRs). This study describes the amount of text data across all notes available to emergency physicians in the EHR, trended over the time since EHR establishment.

Materials and Methods
We conducted a retrospective analysis of EHR data from a large healthcare system, examining the number of notes and a corresponding number of total words and total tokens across all notes available to physicians during patient encounters in the emergency department (ED). We assessed the change in these metrics over a 17-year period between 2006 and 2023.

Results
The study cohort included 730 968 ED visits made by 293 559 unique patients and a total note count of 132 574 964. The median note count for all encounters in 2006 was 5 (IQR 1-16), accounting for 1735 (IQR 447-5521) words. By the last full year of the study period, 2022, the median number of notes had grown to 359 (IQR 84-943), representing 58 662 (IQR 12 615-162 775) words. Note and word counts were higher for admitted patients.

Discussion
The volume of notes available for review by providers has increased by over 30-fold in the 17 years since the implementation of the EHR at a large health system. The task of reviewing these notes has become commensurately more difficult. These data point to the critical need for new strategies and tools for filtering, synthesizing, and summarizing information to achieve the promise of the medical record.
Impact of age on the reproductive output of Hermetia illucens (Diptera: Stratiomyidae)
Authors: Dickerson Amy J , Lemke Noah B , Li Chujun , Tomberlin Jeffery K 
Published: May 2024

Abstract
The current study examined the impact of adult black soldier fly (Hermetia illucens (L.)), age on reproductive output. Four treatments consisting of an equal sex ratio of the following combinations were used: 2-day-old males with 2-day-old females (YMYF); 6-day-old males with 2-day-old females (OMYF); 2-day-old males with 6-day-old females (YMOF); 6-day-old males with 6-day-old females (OMOF). Adult age was a significant factor for the overall number of mating events observed, with YMYF having 2.2× more than YMOF and 2.7× more than OMOF. Time was a significant factor in the number of mating events observed, with 97.8% observed on days 2–6. Age was not a significant factor for the total number of oviposition events, but the inclusion of time as a factor was significant, with 91.5% of all events occurring on days 2–6. Treatment and trial significantly interacted with egg production. This response can be attributed to treatments containing old females, which had a 50% variation in egg output across trials. Treatments containing young females were consistent in terms of egg production. As anticipated, due to oviposition events, 94.8% of total eggs were oviposited on days 2–6. Fecundity and egg hatch were also significantly impacted by female age, with a 50% reduction in both cases across trials occurring in old females. Young females paired with old males had a 20% reduction in egg hatch, but this difference was not statistically significant.