bluuebunny/crossref_metadata_2025_split huggingface dataset:
CD388: A universally protective Drug-Fc Conjugate that targets influenza virus neuraminidase
Authors: Döhrmann Simon , Levin James , Cole Jason N. , Borchardt Allen , Amundson Karin , Almaguer Amanda , Abelovski Elizabeth , Grewal Rajvir , Zuill Douglas , Dedeic Nicholas , Hough Grayson , Fortier Joanne , Donatelli Joanna , Lam Thanh , Chen Zhi-Yong , Jiang Wanlong , Haussener Travis , Noncovich Alain , Balkovec James M. , Bensen Daniel C. , Ong Voon , Brady Thomas P. , Locke Jeffrey , Stein Jeffrey L. , Tari Leslie W. 
Published: June 2024

SUMMARYThe ability of the influenza virus to elude humoral immunity by rapid antigenic shift presents a sustained and urgent threat to human health. Globally, seasonal influenza causes an estimated 3 - 5 million cases of severe disease and 300,000 - 500,000 deaths annually, with increased potential for mortality during pandemics1. The recent outbreaks of avian H5N1 in bird populations, subsequent spread to cattle and appearance in humans, highlight the need for effective broad-spectrum influenza antivirals for treatment, prophylaxis and pandemic preparedness. The narrow, strain-specific immunity induced by current seasonal vaccines and mismatches between vaccine strains and circulating viruses result in limited vaccine effectiveness (VE) rates2. Furthermore, VE is even lower in immune-compromised and - senescent populations3. Strategies that provide durable, universal influenza protection in healthy and high-risk populations are urgently needed. Here, we describe CD388, a first-in-class antiviral drug-Fc conjugate (DFC) in clinical trials for seasonal influenza prevention (NCT05285137andNCT05523089). CD388 comprises a multivalent small molecule inhibitor of influenza virus neuraminidase (NA) linked to a CH1-Fc hybrid domain of human IgG1 engineered for extended half-life. CD388 demonstrated potent, universal activity across influenza A and B viruses, including high pathogenicity and NA resistant strains, a low potential for resistance development, and efficacy in lethal mouse infection models. CD388 is the first therapeutic with the potential for universal prevention of influenza A and B in healthy and high-risk populations.
Investigating the impact of London’s Ultra Low Emission Zone (ULEZ) on children’s health: cohort description and baseline data from the Children’s Health in London and Luton (CHILL) prospective parallel cohort study
Authors: Wood Helen E. , Kalsi Harpal , Cross Louise , Dove Rosamund E. , Scales James , Tsocheva Ivelina , Chavda Jasmine , Colligan Grainne , Lie Esther , Petrovic Kristian , Tomini Florian , Tofolutti Veronica , Day Bill , Keighley Amanda , Critchlow Cheryll , Beevers Sean , Fletcher Monica , Gauderman W. James , Grigg Jonathan , Mihaylova Borislava , Newby Chris , van Sluijs Esther , Kelly Frank , Sheikh Aziz , Randhawa Gurch , Mudway Ian S. , Griffiths Chris J. 
Published: June 2024

ABSTRACTTraffic-related air pollution (TRAP) poses significant health risks particularly for children, with adverse effects that may impact health in later life. Low emission zones are a public health policy designed to reduce TRAP in urban areas.The CHILL (Children’s Health in London and Luton) Study will evaluate the impact of London’s Ultra Low Emission Zone (ULEZ) on children’s health, using a prospective two-arm parallel longitudinal cohort design. CHILL will examine associations between air pollution metrics and lung function growth, plus secondary outcomes. Here we describe the characteristics of the CHILL cohort at baseline, prior to the introduction of the ULEZ.We recruited 3414 children aged 6-9 years attending 84 schools (London – intervention site: 1664 children, 44 schools; Luton – comparator site: 1750 children, 40 schools). Baseline health assessments were conducted in 2018-2019 (before the introduction of the ULEZ in London). 97.0% of recruited children were assessed (London 96.5%, Luton 97.4%), with the primary outcome measure of post-bronchodilator forced expiratory volume in one second being successfully measured in 76.7% (London 76.9%, Luton 76.5%). 92.1% returned a completed parental questionnaire (London 89.3%, Luton 94.7%), including data for analysis of the secondary outcomes. Demographic characteristics and outcomes were similar across the two sites.We established well-matched cohorts of school children, in our intervention (London) and comparator (Luton) sites. Data on primary and secondary outcomes have been successfully collected, which, combined with detailed air quality metrics, provides a robust platform for evaluating the impact of London’s ULEZ on children’s health and development.ClinicalTrials.govNCT04695093(05/01/2021)
Temperature Dependence of the Mechanical Dissipation of Gallium Bonds for Use in Gravitational Wave Detectors
Authors: Haughian Karen , Murray Peter G. , Hill Stuart , Hough James , Lacaille Gregoire , Martin Iain W. , Rowan Sheila , Tait Simon , Bassiri Riccardo , Fejer Martin M. , Khadaka Sudiksha , Markosyan Ashot 
Published: June 2024

The mirror suspensions in gravitational wave detectors demand low mechanical loss jointing to ensure good enough detector performance and to enable the detection of gravitational waves. Hydroxide catalysis bonds have been used in the fused silica suspensions of the GEO600, Advanced LIGO, and Advanced Virgo detectors. Future detectors may use cryogenic cooling of the mirror suspensions and this leads to a potential change of mirror material and suspension design. Other bonding techniques that could replace or be used alongside hydroxide catalysis bonding are of interest. A design that incorporates repair scenarios is highly desirable. Indeed, the mirror suspensions in KAGRA, which is made from sapphire and operated at cryogenic temperatures, have used a combination of hydroxide catalysis bonding and gallium bonding. This Letter presents the first measurements of the mechanical loss of a gallium bond measured between 10 K and 295 K. It is shown that the loss, which decreases with temperature down to the level of (1.8±0.3)×10−4 at 10 K, is comparable to that of a hydroxide catalysis bond.

Published by the American Physical Society
2024
Mental and institutional barriers to creating impact
Authors: van Dijk Hans 
Published: June 2024

PurposeIn this impact paper, I outline how a new inclusion theory generated non-scholarly impact even before it was published and share my personal experiences with mental and institutional barriers to creating that impact. With this, I hope to (1) help readers relate to and understand the issues that they are facing in creating impact and (2) inspire academics and academic institutions to remove obstacles to creating impact.Design/methodology/approachAfter outlining the new theory and the impact it has generated, I autobiographically describe the barriers to impact that I experienced, split up into two categories: mental and institutional barriers.FindingsI discerned six main barriers that I had to overcome. Three of these are mental obstacles: impact order beliefs, prioritizing impact and a lack of examples. The other three are institutional obstacles: a lack of incentives for doing impact work, a lack of resources and an incompatibility between the impact form and the institutional environment.Originality/valueIt can be daunting to hear about the impact that others are having when the journey to get there is being left out and success stories run the risk of pretending that there were no or only a few obstacles involved. In sharing the struggles involved with doing an impact in my particular case, I hope to provide a more realistic insight into the barriers that one is likely to face in doing impact and issue a wider call for removing barriers to making impact.
Re-place-ing space: utilization of public open space after land consolidation in Mojosongo Housing, Surakarta City
Authors: Sunarti S. , Damayanti Maya , Putri Kharunia 
Published: June 2024

Purpose
Replacing space is a challenge in maintaining public open space after land consolidation. Mojosongo subdistrict, Indonesia, also experienced replacing space due to social, economic and physical changes after more 20 years of consolidation. This study aims to analyze the replacing space of public open spaces after land consolidation in the Mojosongo Berseri I Housing.

Design/methodology/approach
This research uses a qualitative method through a case study approach. Secondary data from document reviews land consolidation. Primary data were collected through observation and in-depth interviews using snowball sampling techniques with 35 informants. The analysis techniques used are qualitative descriptive, spatial analysis and pattern matching analysis through comparing empirical case studies with relevant literature.

Findings
Public open spaces have changed function and form. The “replacing space” carried out by the community involves converting public open spaces into built-up areas used for residential purposes and commercial activities. Driving factors for “replacing space” include increase in family members, economic pressures, inflexible building concepts, lack of meaning of space, no supervision/sanctions and not optimal space.

Originality/value
The meaning of replacing space does not only change “space” to “place,” but can also cause changes in the form and function of a place carried out by communities. Thus, space allocation is needed according to community needs, preferences and activities to create a sense of place that is supported by regulations and supervision.
Recalibrating originality for music in copyright law
Authors: Isaac Jithin Saji , Sundharam Asha 
Published: June 2024

Purpose
Though originality is a requirement for copyright protection, the term is not defined, leaving room for differing interpretations. Over the years, there has been a shift in the yardstick for determining originality. The lack of definition gives room for ambiguity and creates hurdle for protection. The difficulty in assessment of originality is more felt in certain forms of work like music, which has its own theories and limitations. Absence of determining tests creates uncertainty for the authors to draw the line between inspiration and infringement. This paper aims to define originality as applicable to each subject matter.

Design/methodology/approach
The methodology used is a qualitative analytical approach and draws from theories and relevant case laws.

Findings
The requirement of “originality” as laid down in the Copyright Act has to be defined with precision. The requirement of originality for different categories of subject matter encompassed within copyright law will differ and so the term should be redefined with respect to each subject matter.

Originality/value
This paper is an original work and canvasses for a definition of the term originality in the Copyright Act with reference to the various subject matter entitled to protection.
Thriving in a weak institutional environment: strategies for engaging with regulative institutions
Authors: Freitas Kenyth Alves de , Flynn Barbara Bechler , Paiva Ely Laureano 
Published: June 2024

PurposeThis paper explores how a firm that is established in an environment characterized by uncertainty can engage with weak regulative institutions by developing operational and institutional capabilities.Design/methodology/approachWe employ a multiple case study approach with seven leading multinational firms in Brazil in industries that vary in industry concentration.FindingsFirms choose among alternative strategies for engaging with regulative institutions as an ongoing process, based on their assessment of four characteristics of the uncertainty they face and their capabilities. Strategies that require a firm to exert greater effort to adapt to institutions or influence institutions have a greater potential to catalyze for developing operational capabilities. Although firms in industries with different concentrations behave similarly in individually adapting to regulative institutions, firms in decentralized industries are more likely to collaborate to influence institutions, which enables them to both access public agents through network partners and better negotiate their own interests.Practical implicationsThis research guides managers in developing institutional engagement strategies to reduce the potential consequences of institutional uncertainty in their supply chain. It also suggests types of institutional capability aligned with decentralized vs concentrated industries.Originality/valueWe extend the construct of institutional engagement strategies from the context of entrance to a new international market to an ongoing process in firms that are established in an environment characterized by weak regulative institutions. We also examine the role of industry concentration in the application of institutional engagement strategies.
The potential impact of EU’s carbon border adjustment mechanism (CBAM): an Australia-China relationship perspective
Authors: Shi Xunpeng , Laurenceson James , Liu Yuanling 
Published: June 2024

Purpose
This paper aims to investigate the multifaced aspects and consequences of the EU Carbon Border Adjustment Mechanism (CBAM) from an Australia-China Relationship perspective.

Design/methodology/approach
This paper leverages the SWOT (Strengths, Weaknesses, Opportunities and Threats) analysis to examine both the internal and external factors that affect Australia and China in the context of the CBAM. In addition, we employ the PEST (Political, Economic, Social and Technological) framework to identify effective strategies for Australia-China cooperation following the implementation of the CBAM.

Findings
Our analysis reveals numerous mutual interests and opportunities for bilateral collaboration, despite challenges and threats, positioning the CBAM as a potentially significant catalyst for joint initiatives.

Practical implications
This paper proposes 10 potential areas for Australia and China cooperation from the political economic social and technological PEST dimensions.

Originality/value
This paper makes a pioneering attempt to explore potential strategies, both individually, and together, that Australia and China can adopt to manage the impact and consequence of CBAM.
Can trust in government help to enhance Indonesian citizens' involvement in Al-based public service?
Authors: Mulyawan Rahman 
Published: June 2024

PurposeGiven its ability to improve user interaction and labor productivity, ease human workloads and cut maintenance costs, public sectors are using AI-based robotic technology (AI-RT) at an accelerated rate. There is, however, little knowledge about the variables affecting citizens' participation when services backed by AI-RT are offered. In order to better understand the elements that influence AI-RT citizens' involvement and the moderating function of trusts in governmental organizations, this article draws on ideas from the Consumer Value Theory.Design/methodology/approachOut of 500 survey forms that were distributed to Indonesian people who had experience in using AI-RT devices in public service hall (e.g. airport’s Auto Gate), 367 returned the completed feedbacks. Data analysis used a step-by-step hierarchical moderated regression examination using SPSS 24 version.FindingsCitizens’ involvement is positively correlated with esthetics and customization and adversely correlated with period expended using the AI-RT. Additionally, the findings imply that citizens who have greater levels of faith in governmental institutions are more likely to benefit favorably from the customization and esthetics of AI-RT.Practical implicationsThe AI-RT must be capable of customizing the distribution of the appropriate materials to the appropriate individual at the appropriate moment, and public managers should guarantee that it is esthetically pleasing. Additionally, they ought to place a high priority on winning the trust of the populace in order to increase citizens’ involvement.Originality/valueThis paper was among the initial efforts that discover the determinants of citizens’ involvement in the AI-RT and the moderating effect of trusts in governmental organizations on the links between predictors and predicted variable, especially in an emerging country such as Indonesia.
Perceptions and motivational factors of Chinese coffee consumers towards robot baristas: a Technology Acceptance Model 2 perspective
Authors: Chong Ka Leong , Zhang Ge 
Published: June 2024

PurposeThis study aims to explore the attitudes and perceptions of Chinese coffee consumers towards robot baristas, considering the proliferation of automated entities within China's coffee sector.Design/methodology/approachEmploying the extended Technology Acceptance Model 2 as its theoretical framework, this research conducts in-depth interviews with 30 Chinese coffee consumers. The laddering technique is utilized, supplemented by video simulation. Thematic analysis is subsequently employed to scrutinize the data.FindingsThe findings delineate six pivotal themes encapsulating Chinese coffee consumers' perceptions of robot baristas – Perceived Introvert Friendliness, Perceived Novelty, Perceived Intellectual Discrepancies, Perceived Efficiency and Reliability, Perceived Emotional Disconnection, and Perceived Labour Market Disruption. Moreover, six motivational themes are identified - Social Status Boosting, Openness to Experience, Ease of Use, Tech-Driven Affordability, Reliable and Uncompromising Quality, and Resistance to Overbearing Service.Research limitations/implicationsThe study is limited by its focus on a specific cultural context. Future research could explore cross-cultural perspectives.Practical implicationsThe findings of this study offer guidance on how to market and position robotic barista services to appeal to consumer preferences and drive adoption.Social implicationsUnderstanding consumer perceptions of robotic baristas has broader social implications, particularly in terms of labour market disruption and the potential impact on traditional coffee professions. Businesses can navigate the social implications of automation more effectively and foster greater acceptance of technological innovations within society.Originality/valueThis study offers insights into the inclinations of Chinese coffee consumers, thereby facilitating informed decision-making and the formulation of effective strategies to expedite the adoption of robotic service.
Managerial ability, political risk and political spending disclosure
Authors: Zhang Huilan , Wang Jing 
Published: June 2024

Purpose
While the determinants of voluntary political spending disclosure have been extensively studied in the literature, there remains a lack of clear evidence regarding the specific impacts of managerial ability and political risk on such disclosure. Thus, the purpose of this study is to shed light on whether and how managerial ability and political risk influence firms’ political spending disclosure.

Design/methodology/approach
This study uses a sample of 2,242 firm-year observations of S&P 500 companies between 2013 and 2021.

Findings
This study finds that firms with high-ability managers generally disclose more information about political spending. This positive relationship between managerial ability and political spending disclosure holds even after conducting additional tests to address potential endogeneity concerns. Furthermore, this study finds that firms operating in high-risk political environments also exhibit a greater propensity to disclose information regarding their political spending. The results remain robust to alternative measures of managerial ability and political risk.

Practical implications
This study suggests that when designing policy to motivate firms to disclose political spending information, policy makers need to be aware of the critical role of managerial ability and idiosyncratic political risk the firm faces. In addition, this study offers insights to shareholders, advocacy groups, regulators and academics interested in understanding the determinants of political spending disclosure.

Originality/value
This study is among the first to provide empirical evidence that political spending disclosure can be explained by managerial ability and political risk. In addition, this study complements the literature on the consequences of managerial ability and political risk. Focusing on voluntary political spending disclosure, this study contributes to a deeper understanding of the factors shaping the overall corporate information environment.
Decentralised automated BIM collaboration: a blockchain and WBS integrated platform
Authors: Stas Stasia , Abrishami Sepehr 
Published: June 2024

PurposeIn the current era of technological advancement, the architectural, engineering and construction (AEC) industry is undergoing a radical transformation, prompting researchers to explore new breakthroughs that can revolutionise the construction process. This paper delves into the use of cutting-edge technologies such as building information management (BIM), blockchain and the Internet of Things (IoT), along with advanced management techniques such as work breakdown structure (WBS) and Agile thinking, to enhance the industry’s efficiency, productivity, quality and cost-effectiveness. Moreover, the pressing need for a sustainable, secure and transparent sector amplifies the significance of the proposed research.Design/methodology/approachThis study’s research approach comprises an intensive literature review to construct a conceptual framework, followed by an exploratory questionnaire to validate the framework.FindingsThis paper demonstrates how blockchain combined with a WBS and a BIM platform may boost collaboration in order to experience efficient and trusted workflow scenarios that can overcome many of the challenges given in a traditional building technique. The research findings emphasise the benefits of the proposed new mentality approach, which incorporates all of the previously described tools/techniques to the business.Research limitations/implicationsThis paper highlights the advantages of leveraging a combination of blockchain, WBS and BIM platforms to boost collaboration and enable efficient and trustworthy workflow scenarios that can surmount the difficulties inherent in traditional AEC industry collaboration methods.Originality/valueThis study provides original insights into the challenges and opportunities of using blockchain for AEC collaboration, by exploring the potential of decentralised blockchain networks to improve the security, efficiency and transparency of collaborative data sharing and management.
Where has everyone gone? Depopulation and voting behaviour in Spain
Authors: SÁNCHEZ‐GARCÍA ÁLVARO , RODON TONI , DELGADO‐GARCÍA MARIA 
Published: June 2024

AbstractIn many European countries, people increasingly leave rural or small municipalities to live and work in urban or metropolitan environments. Although previous work on the ‘left behind’ places has examined the relationship between the rural–urban divide and vote choice, less is known about how depopulation affects electoral behaviour. Is there a relationship between experiencing a loss in population and support for the different parties? We investigate this question by examining the Spanish case, a country where the topic of depopulation has become a salient issue in political competition. Using a newly compiled dataset, we also explore whether the relationship between depopulation and electoral returns is moderated by municipality size, local compositional changes, the loss of public services and changes in amenities. Our findings show that depopulated municipalities give higher support to the main Conservative party, mainly in small municipalities. Yet, municipalities on the brink of disappearance are more likely to give larger support to the far‐right. Results overall show that the effect of depopulation seems to be driven by compositional changes, and not as a result of losing public services or a deterioration of the vibrancy of the town. Our findings have important implications for our understanding of the relationship between internal migration and electoral behaviour.