bluuebunny/crossref_metadata_2025_split huggingface dataset:
Coronary Microvascular Dysfunction Induced by Primary Hyperparathyroidism is Restored After Parathyroidectomy
Authors: Osto Elena , Fallo Francesco , Pelizzo Maria Rosa , Maddalozzo Anna , Sorgato Nadia , Corbetti Francesco , Montisci Roberta , Famoso Giulia , Bellu Roberto , Lüscher Thomas F. , Iliceto Sabino , Tona Francesco 
Published: July 2012

Background—
Symptomatic primary hyperparathyroidism (PHPT) is associated with increased cardiovascular mortality. However, data on the association between asymptomatic PHPT and cardiovascular risk are lacking. We assessed coronary flow reserve (CFR) as a marker of coronary microvascular function in asymptomatic PHPT of recent onset.

Methods and Results—

We studied 100 PHPT patients (80 women; age, 58±12 years) without cardiovascular disease and 50 control subjects matched for age and sex. CFR in the left anterior descending coronary artery was detected by transthoracic Doppler echocardiography, at rest, and during adenosine infusion. CFR was the ratio of hyperemic to resting diastolic flow velocity. CFR was lower in PHPT patients than in control subjects (3.0±0.8 versus 3.8±0.7;
P
<0.0001) and was abnormal (≤2.5) in 27 patients (27%) compared with control subjects (4%;
P
=0.0008). CFR was inversely related to parathyroid hormone (PTH) levels (
r
=−0.3,
P
<0.004). In patients with CFR ≤2.5, PTH was higher (26.4 pmol/L [quartiles 1 and 3, 16 and 37 pmol/L] versus 18 [13–25] pmol/L;
P
<0.007), whereas calcium levels were similar (2.9±0.1 versus 2.8±0.3 mmol/L;
P
=0.2). In multivariable linear regression analysis, PTH, age, and heart rate were the only factors associated with CFR (
P
=0.04,
P
=0.01, and
P
=0.006, respectively). In multiple logistic regression analysis, only PTH increased the probability of CFR ≤2.5 (
P
=0.03). In all PHPT patients with CFR ≤2.5, parathyroidectomy normalized CFR (3.3±0.7 versus 2.1±0.5;
P
<0.0001).

Conclusions—
PHPT patients have coronary microvascular dysfunction that is completely restored after parathyroidectomy. PTH independently correlates with the coronary microvascular impairment, suggesting a crucial role of the hormone in explaining the increased cardiovascular risk in PHPT.
Association of Body Image and Health Beliefs With Health Behaviors in Patients With Diabetes
Authors: Chao Hailun , Lao Iha , Hao Lyhjyh , Lin Chienhung 
Published: July 2012

Purpose The purpose of this study was to investigate relationships between body image, health beliefs, and health behavior in patients with diabetes classified according to body mass index (BMI). Methods A cross-sectional study was conducted in a community hospital between January and April 2010. One-hundred-sixty-eight patients with diabetes were enrolled. Main measure was the previously published and validated Health Belief Questionnaire. Data were analyzed and compared between two groups, one with BMI ≥ 24 Kg/m2 and another with BMI < 24 Kg/m2. Results Perceived body image affected health behavior of patients with BMI ≥ 24 Kg/m2 but did not affect health behavior in patients with BMI < 24 Kg/m2. Multivariate analysis found a positive association between health behavior and appearance evaluation and between health behavior and health evaluation in high BMI group. No significant association was found between body image and health behavior in the low BMI group. Patients with high BMI had lower body image than patients with low BMI as demonstrated by results of appearance evaluation, health evaluation, prevention behavior, and benefits. Conclusions Perceived body image and health beliefs are associated with self-reported health behavior among patients with diabetes with BMI measurement greater than 24 Kg/m2. Diabetes educators may apply the findings of this study and the Health Belief Questionnaire to instruct and monitor patients with diabetes about self management behaviors.
Genetic dissection of growth, wood basic density and gene expression in interspecific backcrosses of Eucalyptus grandis and E. urophylla
Authors: Kullan Anand Raj Kumar , van Dyk Maria M , Hefer Charles A , Jones Nicoletta , Kanzler Arnulf , Myburg Alexander A 
Published: July 2012

AbstractBackgroundF1hybrid clones ofEucalyptus grandisandE. urophyllaare widely grown for pulp and paper production in tropical and subtropical regions. Volume growth and wood quality are priority objectives inEucalyptustree improvement. The molecular basis of quantitative variation and trait expression in eucalypt hybrids, however, remains largely unknown. The recent availability of a draft genome sequence (http://www.phytozome.net) and genome-wide genotyping platforms, combined with high levels of genetic variation and high linkage disequilibrium in hybrid crosses, greatly facilitate the detection of quantitative trait loci (QTLs) as well as underlying candidate genes for growth and wood property traits. In this study, we used Diversity Arrays Technology markers to assess the genetic architecture of volume growth (diameter at breast height, DBH) and wood basic density in four-year-old progeny of an interspecific backcross pedigree ofE. grandisandE. urophylla. In addition, we used Illumina RNA-Seq expression profiling in theE. urophyllabackcross family to identify cis- and trans-acting polymorphisms (eQTLs) affecting transcript abundance of genes underlying QTLs for wood basic density.ResultsA total of five QTLs for DBH and 12 for wood basic density were identified in the two backcross families. Individual QTLs for DBH and wood basic density explained 3.1 to 12.2% of phenotypic variation. Candidate genes underlying QTLs for wood basic density on linkage groups 8 and 9 were found to share trans-acting eQTLs located on linkage groups 4 and 10, which in turn coincided with QTLs for wood basic density suggesting that these QTLs represent segregating components of an underlying transcriptional network.ConclusionThis is the first demonstration of the use of next-generation expression profiling to quantify transcript abundance in a segregating tree population and identify candidate genes potentially affecting wood property variation. The QTLs identified in this study provide a resource for identifying candidate genes and developing molecular markers for marker-assisted breeding of volume growth and wood basic density. Our results suggest that integrated analysis of transcript and trait variation in eucalypt hybrids can be used to dissect the molecular basis of quantitative variation in wood property traits.
Osteomyelitis of a long bone due to Fusobacterium nucleatum and Actinomyces meyeriin an immunocompetent adult: A case report and literature review
Authors: Lee Min Ji , Ha Young Eun , Park Hye Yon , Lee Jun Hee , Lee Yoon Jung , Sung Ki Sun , Kang Cheol-In , Chung Doo Ryeon , Song Jae-Hoon , Peck Kyong Ran 
Published: July 2012

Abstract

Background

Fusobacterium species are uncommon causes of osteomyelitis. These organisms are normal flora of the oral cavity. Therefore, they mostly cause osteomyelitis of the head and neck. Hematogenous osteomyelitis at distant sites other than the head and neck has rarely been reported in pediatric or immunocompromised patients. Here, we report the first case of osteomyelitis of a long bone combined with a muscle abscess due to Fusobacterium nucleatum in an otherwise healthy adult.

Case presentation
A 59-year-old Korean man was admitted for pain and swelling of the right lower leg, which had been persistent for two weeks. Magnetic resonance imaging showed osteomyelitis of the right fibula with a surrounding muscle abscess of the right lower leg. Incision and drainage was performed, and repetitive tissue cultures grew F. nucleatum. In this patient, it was presumed that recurrent periodontitis caused hematogenous seeding of F. nucleatum to a distant site leading to osteomyelitis with a muscle abscess. The patient was successfully treated with intravenous ampicillin-sulbactam for three weeks and oral amoxicillin-clavulanate for eight weeks. He also underwent repeated surgical drainage. He has no evidence of recurrence after seven months of follow-up.

Conclusions
Clinicians should be aware that F. nucleatum could be the etiologic agent of hematogenous osteomyelitis of a long bone in an immunocompetent patient.
Atypical vitelliform macular dystrophy misdiagnosed as chronic central serous chorioretinopathy: case reports
Authors: Lee Young Seob , Kim Eung-Suk , Kim Moosang , Kim Young-Gyun , Kwak Hyung-Woo , Yu Seung-Young 
Published: July 2012

Abstract

Background
To report two cases of atypical vitelliform macular dystrophy misdiagnosed as chronic central serous chorioretinopathy.

Case presentation
Two patients with incidentally discovered abnormalities of the retina without specific symptoms were referred to our hospital for consultation. Bilateral macula atrophic lesions were observed and optical coherence tomography revealed serous retinal detachment in the macula. Fluorescein angiography showed multiple leakages around the central hypofluorescent area and indocyanine green angiography showed partially dilated choroidal vessels. Fundus autofluorescence (FAF) showed a decreasing pattern of autofluorescence in the subretinal fluid area, and increasing autofluorescence at the border of the serous retinal detachment. Both patients were diagnosed with chronic central serous chorioretinopathy. Photodynamic therapy and intravitreal bevacizumab injection were administered for engorged choroidal vessels during follow-up, but neither patient showed improvement in symptoms or ophthalmologic findings. Based on re-evaluation by fundus photography, optical coherence tomography, fluorescein angiography, and comparison of the results of FAF with the first visit, vitelliform macular dystrophy was suspected and a definite diagnosis was made by electrooculography and genetic testing.

Conclusion
In patients with continuous serous retinal detachment without response to photodynamic therapy or intravitreal bevacizumab injection, careful fundus exam and FAF can be used to diagnose atypical vitelliform macular dystrophy.
Ocular toxicity of authentic lunar dust
Authors: Meyers Valerie E , Garcìa Hector D , Monds Kathryn , Cooper Bonnie L , James John T 
Published: July 2012

Abstract

Background
Dust exposure is a well-known occupational hazard for terrestrial workers and astronauts alike and will continue to be a concern as humankind pursues exploration and habitation of objects beyond Earth. Humankind’s limited exploration experience with the Apollo Program indicates that exposure to dust will be unavoidable. Therefore, NASA must assess potential toxicity and recommend appropriate mitigation measures to ensure that explorers are adequately protected. Visual acuity is critical during exploration activities and operations aboard spacecraft. Therefore, the present research was performed to ascertain the ocular toxicity of authentic lunar dust.

Methods
Small (mean particle diameter = 2.9 ± 1.0 μm), reactive lunar dust particles were produced by grinding bulk dust under ultrapure nitrogen conditions. Chemical reactivity and cytotoxicity testing were performed using the commercially available EpiOcularTM assay. Subsequent in vivo Draize testing utilized a larger size fraction of unground lunar dust that is more relevant to ocular exposures (particles <120 μm; median particle diameter = 50.9 ± 19.8 μm).

Results

In vitro testing indicated minimal irritancy potential based on the time required to reduce cell viability by 50% (ET50). Follow-up testing using the Draize standard protocol confirmed that the lunar dust was minimally irritating. Minor irritation of the upper eyelids was noted at the 1-hour observation point, but these effects resolved within 24 hours. In addition, no corneal scratching was observed using fluorescein stain.

Conclusions
Low-titanium mare lunar dust is minimally irritating to the eyes and is considered a nuisance dust for ocular exposure. No special precautions are recommended to protect against ocular exposures, but fully shielded goggles may be used if dust becomes a nuisance.
Wound healing activities of different extracts of Centella asiatica in incision and burn wound models: an experimental animal study
Authors: Somboonwong Juraiporn , Kankaisre Mattana , Tantisira Boonyong , Tantisira Mayuree H 
Published: July 2012

AbstractBackgroundThe efficacy ofCentella asiaticafor incision and burn wounds are not fully understood. Here, we report the wound healing activities of sequential hexane, ethyl acetate, methanol, and water extracts ofCentella asiaticain incision and partial-thickness burn wound models in rats.MethodsMale Sprague–Dawley rats weighing 250–300 g were randomly divided into incision and burn wound groups. Each group was stratified into seven subgroups: (1) untreated; (2) NSS-; (3) Tween 20®- (vehicle control); (4) hexane extract-; (5) ethyl acetate extract-; (6) methanol extract-; and (7) aqueous extract-treated groups. The test substances were applied topically once daily. The tensile strength of the incision wound was measured on the seventh day after wound infliction. The general appearance and degree of wound healing of the burn wound were assessed on Days 3, 7, 10 and 14 after burn injury and prior to histopathological evaluation.ResultsOn the seventh day after wound infliction, the tensile strength of incision wound in all extract-treated groups was significantly higher than that of the vehicle control (Tween 20®), but comparable to the NSS-treated group. The degrees of healing in the burn wound with the four extracts were significantly higher than that of the control on Days 3, 10 and 14. Histopathological findings on Day 14 after burn injury revealed prominent fibrinoid necrosis and incomplete epithelialization in the control and untreated groups, whereas fully developed epithelialization and keratinization were observed in all extract-treated groups. Analysis by thin layer chromatography demonstrated that the phyto-constituents β-sitosterol, asiatic acid, and asiaticoside and madecassocide were present in the hexane, ethyl acetate and methanol extracts, respectively.ConclusionsAll extracts ofCentella asiaticafacilitate the wound healing process in both incision and burn wounds. Asiatic acid in the ethyl acetate extract seemed to be the most active component for healing the wound.
Ethnic differences in the use of intrapartum epidural analgesia
Authors: Jiménez-Puente Alberto , Benítez-Parejo Nicolás , Del Diego-Salas Jorge , Rivas-Ruiz Francisco , Maañón-Di Leo Claudio 
Published: July 2012

Abstract

Background
Obstetric epidural analgesia (EA) is widely applied, but studies have reported that its use may be less extensive among immigrant women or those from minority ethnic groups. Our aim was to examine whether this was the case in our geographic area, which contains an important immigrant population, and if so, to describe the different components of this phenomenon.

Methods
Cross-sectional observational study. Setting: general acute care hospital, located in Marbella, southern Spain. Analysis of computer records of deliveries performed from 2004 to 2010. Comparison of characteristics of deliveries according to the mothers’ geographic origins and of vaginal deliveries noting whether EA was received, using univariate and bivariate statistical analysis and multiple logistic regression (MLR).

Results
A total of 21,034 deliveries were recorded, and 37.4% of these corresponded to immigrant women. EA was provided to 61.1% of the Spanish women and to 51.5% of the immigrants, with important variations according to geographic origin: over 52% of women from other European countries and South America received EA, compared with around 45% of the African women and 37% of the Asian women. These differences persisted in the MLR model after adjusting for the mother's age, type of labor initiation, the weight of the neonate and for single or multiple gestation. With the Spanish patients as the reference category, all the other countries of origin presented lower probabilities of EA use. This was particularly apparent for the patients from Asia (OR 0.38; 95%CI 0.31-0.46), Morocco (OR 0.49; 95%CI 0.43-0.54) and other Africa (OR 0.55; 95%CI 0.37-0.81).

Conclusions
We observed a different use of EA in vaginal deliveries, according to the geographic origin of the women. The explanation for this involves a complex set of factors, depending both on the patient and on the healthcare staff.
Therapeutic efficacy and safety of dihydroartemisinin-piperaquine versus artesunate-mefloquine in uncomplicated Plasmodium falciparum malaria in India
Authors: Gargano Nicola , Ubben David , Tommasini Silva , Bacchieri Antonella , Corsi Marco , Bhattacharyya Prabhash C , Rao Bappanad HK , Dubashi Nagesh , Dev Vas , Ghosh Susanta K , Kumar Ashwani , Srivastava Bina , Valecha Neena 
Published: July 2012

Abstract

Background
Resistance in Plasmodium falciparum to commonly used anti-malarial drugs, especially chloroquine, is being increasingly documented in India. By 2007, the first-line treatment for uncomplicated malaria has been revised to recommend artemisinin-based combination therapy (ACT) for all confirmed P. falciparum cases.

Objective
The objective of this study was to compare the efficacy, safety and tolerability between dihydroartemisinin-piperaquine (DP) and artesunate plus mefloquine (A + M) drug combinations in the treatment of uncomplicated P. falciparum malaria in India.

Methods
Between 2006 and 2007, 150 patients with acute uncomplicated P. falciparum malaria were enrolled, randomized to DP (101) or A + M (49) and followed up for 63 days as part of an open-label, non-inferiority, randomized, phase III multicenter trial in Asia.

Results
The heterogeneity analysis showed no statistically significant difference between India and the other countries involved in the phase III study, for both the PCR-corrected and uncorrected cure rates. As shown at the whole study level, both forms of ACT were highly efficacious in India. In fact, in the per protocol population, the 63-day cure rates were 100% for A + M and 98.8% for DP. The DP combination exerted a significant post-treatment prophylactic effect, and compared with A + M a significant reduction in the incidence of new infections for DP was observed (respectively 17.1% versus 7.5% of patients experienced new infection within follow up). Parasite and fever clearance was rapid in both treatment arms (median time to parasite clearance of one day for both groups). Both DP and A + M were well tolerated, with the majority of adverse events of mild or moderate severity. The frequencies of individual adverse events were generally similar between treatments, although the incidence of post treatment adverse events was slightly higher in patients who received A + M with respect to those treated with DP.

Conclusion
DP is a new ACT displaying high efficacy and safety in the treatment of uncomplicated P. falciparum malaria and could potentially be considered for the first-line treatment of uncomplicated falciparum malaria in India.

Trial registration
Current Controlled Trials ISRCTN 81306618
Strong convergence theorems for solving a general system of finite variational inequalities for finite accretive operators and fixed points of nonexpansive semigroups with weak contraction mappings
Authors: Onjai-uea Nawitcha , Katchang Phayap , Kumam Poom 
Published: July 2012

Abstract
In this paper, we prove a strong convergence theorem for finding a common solution of a general system of finite variational inequalities for finite different inverse-strongly accretive operators and solutions of fixed point problems for a nonexpansive semigroup in a Banach space based on a viscosity approximation method by using weak contraction mappings. Moreover, we can apply the above results to find the solutions of the class of k-strictly pseudocontractive mappings and apply a general system of finite variational inequalities into a Hilbert space. The results presented in this paper extend and improve the corresponding results of Ceng et al. (2008), Katchang and Kumam (2011), Wangkeeree and Preechasilp (2012), Yao et al. (2010) and many other authors.

MSC:47H05, 47H10, 47J25.
Fixed point theorems for left amenable semigroups of non-Lipschitzian mappings in Banach spaces
Authors: Huang Qianglian , Zhu Lanping , Li Gang 
Published: July 2012

Abstract
In this paper, we provide the existence and convergence theorems of fixed points for left amenable semigroups of asymptotically nonexpansive type mappings in general Banach spaces, which extend and improve many recent results in this area.

MSC:47H09, 47H10, 47H20.
Characterization and compilation of polymorphic simple sequence repeat (SSR) markers of peanut from public database
Authors: Zhao Yongli , Prakash Channapatna S , He Guohao 
Published: July 2012

Abstract

Background
There are several reports describing thousands of SSR markers in the peanut (Arachis hypogaea L.) genome. There is a need to integrate various research reports of peanut DNA polymorphism into a single platform. Further, because of lack of uniformity in the labeling of these markers across the publications, there is some confusion on the identities of many markers. We describe below an effort to develop a central comprehensive database of polymorphic SSR markers in peanut.

Findings
We compiled 1,343 SSR markers as detecting polymorphism (14.5%) within a total of 9,274 markers. Amongst all polymorphic SSRs examined, we found that AG motif (36.5%) was the most abundant followed by AAG (12.1%), AAT (10.9%), and AT (10.3%).The mean length of SSR repeats in dinucleotide SSRs was significantly longer than that in trinucleotide SSRs. Dinucleotide SSRs showed higher polymorphism frequency for genomic SSRs when compared to trinucleotide SSRs, while for EST-SSRs, the frequency of polymorphic SSRs was higher in trinucleotide SSRs than in dinucleotide SSRs. The correlation of the length of SSR and the frequency of polymorphism revealed that the frequency of polymorphism was decreased as motif repeat number increased.

Conclusions
The assembled polymorphic SSRs would enhance the density of the existing genetic maps of peanut, which could also be a useful source of DNA markers suitable for high-throughput QTL mapping and marker-assisted selection in peanut improvement and thus would be of value to breeders.