bluuebunny/crossref_metadata_2025_split huggingface dataset:
Radiofrequency ablation of an intercalyceal neoplasm in a transplanted kidney using percutaneous nephrostomy for cooling — Safety and early result
Authors: Kozma Veronika , Végső Gy. , Deák P. Á. , Hartmann E. , Németh A. , Török Sz. , Langer R. , Doros A. 
Published: March 2010

Abstract
Kidney neoplasms can occur after kidney transplantation in low percentage. In this report we delineate a rare case of neoplasm in the transplanted kidney detected on screening ultrasonographic examination. Due to the intercalyceal location of the tumor percutaneous radiofrequency ablation was planned with continuous cooling the collecting system avoiding the thermal damage. To the best of our knowledge this method has never been reported applying in transplanted kidney. The two-month CT follow-up verified no residual tumor and the kidney function remained in normal range during this period. These facts imply that the method can be safely applied.
Rotational atherectomy of a complex, highly calcified left anterior descending artery lesion
Authors: Édes I. F. , Ruzsa Z. , Szűk T. , Szabó Gy. , Merkely B. 
Published: March 2010

Abstract
Rotational atherectomy (RA) is an advanced coronary debulking technique, often used in cases, where traditional percutaneous coronary intervention (PCI) methods (e.g. balloon predilatation, use of cutting balloons, direct stenting etc.) are inadequate. We report a case of a male patient, who previously underwent PCI of the right coronary artery (RCA) and was free of chest pain for several weeks, but his clinical symptoms have developed again. Angiography showed a “de novo”, highly calcified left anterior descending (LAD) lesion that, after high-pressure balloon inflation, failed to dilate, thus the intervention was suspended. RA was scheduled for the patient within one month. As a complication of the previous LAD dilatation attempt, a chronic dissection of the target lesion occurred. Problems arose during the direct wiring attempt of the main vessel and the true lumen was only found via plaque modification, after accessing a small septal branch. Accessing the true lumen was only possible by using a conventional cross-wire. This was exchanged to a RA wire, with the help of an over-the-wire (OTW) balloon catheter. RA and debulking of the target lesion was performed. An everolimus-eluting stent (BioMatrix, Biosensors Europe, Morges, Switzerland) was implanted, with excellent results. The patient is free of clinical symptoms since the intervention, which took place 14 months ago.
Allergotoxicology: Research of Pollutant Influence on the Development of Allergic Reactions
Authors: Kanceljak-Macan Božica 
Published: March 2010

Alergotoksikologija: Istraživanja Utjecaja Polutanata na Pojavu Alergijskih ReakcijaAlergotoksikologija je znanstvenoistraživačko područje koje se bavi ispitivanjem utjecaja polutanata (onečišćivača zraka) na nastanak alergijskih reakcija i bolesti. Ispitivanja su prvobitno bila usmjerena na polutante vanjskih prostora, a u novije vrijeme sve više na polutante unutarnjih prostora u kojima ljudi provode većinu vremena. Polutanti po svojoj prirodi mogu biti krute, tekuće ili plinovite čestice, koje se razlikuju s obzirom na veličinu, sastav i izvor iz kojeg nastaju. S obzirom na izvor mogu biti biološkog i nebiološkog podrijetla. Polutanti koji su predmet suvremenih istraživanja s gledišta nastanka alergijskih bolesti su respirabilne krute čestice, ozon, dušični oksidi i bioaerosoli. Mehanizam djelovanja polutanata ovisi o veličini čestica, njihovoj topljivosti i mjestu ulaska u organizam. Dosadašnja ispitivanja su pokazala da različite čestice uvjetuju različite imunosne i neimunosne odgovore u organizmu. Interakcija polutanata i alergena može se zbivati izvan eksponirane osobe, tj. sa samim alergenom ili u eksponiranoj osobi na sluznicama i koži. Polutanti mogu biti nosioci alergena i mogu interferirati na različitim nivoima u nastanku alergijske reakcije. U ovom prikazu razmatraju se dosadašnja saznanja o mehanizmima djelovanja polutanata na alergene, na imunosni sustav izloženih osoba na osnovi epidemioloških populacijskih istraživanja, kliničkih studija ekspozcije u kontroliranim uvjetima i eksperimentalnih testnih sistemain vivoiin vitro.
Dustfall Measurements in Primorsko-Goranska County, 1975-2008
Authors: Mićović Vladimir , Alebić-Juretić Ana , Matković Nada , Crvelin Goran 
Published: March 2010

Dustfall Measurements in Primorsko-Goranska County, 1975-2008Dustfall measurements in Primorsko-goranska county started in 1975 in the Bakar Bay (Site 2 - Bakar and Site 3 - Kraljevica). The measurements were extended to the city of Rijeka (Site 1 - Rijeka) in 1982, to the nearby islands (Site 4 - Krk and Site 5 - Cres) in 1986, and inland to Gorski Kotar (Site 6 - Delnice and Site 7 - Lividraga) in 1995. This article brings the results of dustfall measurements from 1975 to 2008. Dustfall was low in the city, the nearby islands, and Gorski Kotar. Recommended and limit values were occasionally exceeded in the Bakar Bay due to emissions from the coke plant and harbour at Site 2 (1979-1997) and from the shipyard at Site 3. Lead content in the dustfall was below the national limits, save for two occasions at Site 2. Deposition of sulphur and nitrogen at the inland sites were below the respective critical load values.
Identification of Counterfeit Medicines for Erectile Dysfunction from an Illegal Supply Chain
Authors: Tomić Siniša , Milčić Neven , Sokolić Milenko , Martinac Adrijana 
Published: March 2010

Identification of Counterfeit Medicines for Erectile Dysfunction from an Illegal Supply ChainThe appearance of counterfeit medicines in supply chains is a global public health problem that may seriously affect patients. Counterfeit drugs do not meet quality standards and do not declare their real composition and/or source for the purposes of fraud. They may be generic or innovative, they may contain genuine constituents in a fake packaging, or wrong ingredients, or inactive ingredients, or an incorrect quantity of the active substance. In Croatia, no cases of counterfeit medicines have been detected so far, but the Agency for Medicinal Products and Medical Devices has received 34 samples of medicines and other products for testing from Zagreb City Police. The samples included medicines for erectile dysfunction: sildenafil, tadalafil, and vardenafil. Twenty-three samples of tablets without marketing authorisation in Croatia were tested with high-performance liquid chromatography (HPLC) for the declared sildenafil and tadalafil content. Samples labelled 1 (batch T/33), 3 (batch T/33), 5 (batch 4), 6 (batch M0016J), 10 (batch T-070235), 12 (batch T-070544), 15 (batch 314833201), 16 (batch 832718474), and 17 (batch 504830028) containing sildenafil and samples labelled 20 (batch 070356), 21 (batch 05668), and 22 (batch T 378 5) containing tadalafil did not contain the active substance within the acceptable 95 % to 105 % margin of deviation from the declared content. While most samples cannot be described as fake with a reasonable amount of certainty, there is still a suspicion of counterfeit. A correct conclusion can be drawn only with the assistance of the manufacturers and by conducting additional laboratory tests.
Assessment of Cyto/Genotoxicity of Irinotecan in V79 Cells Using the Comet, Micronucleus, and Chromosome Aberration Assay
Authors: Kašuba Vilena , Rozgaj Ružica , Gamulin Marija , Trošić Ivančica 
Published: March 2010

Assessment of Cyto/Genotoxicity of Irinotecan in V79 Cells Using the Comet, Micronucleus, and Chromosome Aberration AssayIrinotecan is a topoisomerase I interactive agent, widely used in the treatment of metastatic colorectal cancer. The genotoxic effects of the maximum single dose (18 μg mL-1), recommended monotherapy dose (9 μg mL-1), and recommended combined therapy dose (4.5 μg mL-1) of irinotecan were studied on V79 cells using the comet assay, chromosome aberration assay, and micronucleus test. The cells were treated with irinotecan for 2 h or 24 h. The statistical significance of the results was determined using the one-way ANOVA test and a nonparametric Mann Whitney U test. The comet assay did not show dose-dependent or time-dependent effects. The chromosome aberration analysis showed large DNA rearrangements, i.e., chromosome exchanges. Although the exposed cultures showed a significant increase in micronucleated cells in respect to control, no dose-dependent relation was established among the treated cultures. Time-dependent effect was also not observed.
Thallium Toxicity in Humans
Authors: Cvjetko Petra , Cvjetko Ivan , Pavlica Mirjana 
Published: March 2010

Thallium Toxicity in HumansThallium is a naturally occurring trace element, widely distributed in the earth's crust, but at very low concentrations. It does not have a known biological use and does not appear to be an essential element for life. It has been considered one of the most toxic heavy metals.Occasionally, there are reports on thallium poisoning as results of suicide or murder attempt or accident. The main threat to humans is through occupational exposure, environmental contamination, and accumulation in food, mainly in vegetables grown on contaminated soil. Increasing use in emerging new technologies and demanding high-tech industry constantly raise concern about exposure risk to all living organisms. Thallium is considered a cumulative poison that can cause adverse health effects and degenerative changes in many organs. The effects are the most severe in the nervous system. The exact mechanism of thallium toxicity still remains unknown, although impaired glutathione metabolism, oxidative stress, and disruption of potassium-regulated homeostasis may play a role. The lack of data about mutagenic, carcinogenic, or teratogenic effects of thallium compounds in humans calls for further research.
Cage Exposure of European Sea Bass (Dicentrarchus Labrax) for in Situ Assessment of Pollution-Related Genotoxicity
Authors: Šrut Maja , Štambuk Anamaria , Pavlica Mirjana , Klobučar Göran 
Published: March 2010

Cage Exposure of European Sea Bass (Dicentrarchus Labrax) for in Situ Assessment of Pollution-Related GenotoxicityGenotoxic effects are often the earliest signs of pollution-related environmental disturbance. In this study, we used the comet assay and micronucleus test to assess DNA damage in the erythrocytes of the European sea bass (Dicentrarchus labrax) exposed to environmental pollution in situ. Fish were collected from a fish farm in the Trogir Bay and their cages placed at an unpolluted reference site Šolta (Nečujam Bay) and a polluted site Vranjic (Kaštela Bay) for four weeks. A group of fish which remained at the fish farm Trogir Bay were used as the second control group. Fish exposed at the Vranjic site showed a significantly higher erythrocyte DNA damage, measured by the comet assay, than either control group. Micronucleus induction showed a similar gradient of DNA damage, but did not reach statistical significance. Our results show that cage exposure of a marine fish D. labrax can be useful in environmental biomonitoring and confirm the comet assay as a suitable tool for detecting pollution-related genotoxicity.
Antineoplastic Drugs as a Potential Risk Factor in Occupational Settings: Mechanisms of Action at the Cell Level, Genotoxic Effects, and Their Detection Using Different Biomarkers
Authors: Kopjar Nevenka , Želježić Davor , Kašuba Vilena , Rozgaj Ružica 
Published: March 2010

Antineoplastični Lijekovi Kao Čimbenik Rizika u Radnom Okolišu: Mehanizmi Djelovanja na Razini Stanice i Pregled Metoda za Otkrivanje Njihovih Genotoksičnih UčinakaU članku je prikazana osnovna podjela antineoplastičnih lijekova prema mehanizmima djelovanja na razini stanice. Objašnjeni su mehanizmi genotoksičnosti najvažnijih vrsta lijekova koji se primjenjuju u okviru uobičajenih protokola za liječenje zloćudnih novotvorina. Navedena je važeća klasifikacija antineoplastika prema kancerogenom potencijalu, podaci o mutagenom potencijalu te je prikazana njihova podjela u skladu s anatomsko-terapijsko-kemijskim sustavom klasifikacije. Sustavno su prikazani najvažniji rezultati svjetskih i hrvatskih istraživanja na populacijama radnika izloženih antineoplasticima, provedenih u razdoblju 1980.-2009. s pomoću četiri najčešće primjenjivane metode: analize izmjena sestrinskih kromatida, analize kromosomskih aberacija, mikronukleus-testa i komet-testa. Objašnjena su osnovna načela navedenih metoda te raspravljene njihove prednosti i nedostaci. Biološki pokazatelji daju važne podatke o individualnoj osjetljivosti profesionalno izloženih ispitanika koji mogu poslužiti unaprjeđenju postojećih uvjeta rada i upravljanju rizicima pri izloženosti genotoksičnim agensima. Na osnovi prednosti i nedostataka citogenetičkih metoda zaključeno je da je mikronukleus-test, koji podjednako uspješno dokazuje klastogene i aneugene učinke, jedna od najboljih metoda dostupnih za otkrivanje štetnih djelovanja antineoplastičnih lijekova koji su u aktivnoj primjeni.
Evaluation of various sample pre-treatment methods for total and inorganic mercury determination in biological certified reference materials by CVAAS technique
Authors: Matusiewicz Henryk , Stanisz Ewa 
Published: March 2010

Abstract
Sample preparation methods for non-separation cold vapor atomic absorption spectrometry (CVAAS) sequential inorganic mercury speciation in biological certified reference materials (CRMs) were investigated. The methylmercury concentration was calculated as the difference between total and inorganic mercury. Microwave-assisted decomposition method, and three ultrasonic extraction procedures based on acid leaching with HCl and HCOOH and solubilization with TMAH were employed as sample preparation methods. The replacement of a sample decomposition procedure by extraction prior to analysis by CVAAS, as well as the aspect of speciation analysis is discussed. The limits of detection in the sample were determined as 50 and 10 ng L−1 for inorganic and total mercury, which corresponds to absolute detection limits of 40 and 8 ng g−1 for inorganic and total mercury, respectively. The results were in good agreement with the 95% confidence level t-test of the certified values for total and inorganic mercury in the reference materials investigated. From the analysis of the CRMs, it was evident that the difference between the total and inorganic mercury concentrations agrees with the methylmercury concentration. The relative standard deviation was better than 11% for most of the samples.
The thermodynamic dissociation constants of methotrexate by the nonlinear regression and factor analysis of multiwavelength spectrophotometric pH-titration data
Authors: Meloun Milan , Ferenčíková Zuzana , Vrána Aleš 
Published: March 2010

Abstract
The mixed dissociation constants of methotrexate — chemically (2S)-2-[(4-{[(2,4-diamino-7,8-dihydropteridin-6-yl)methyl] (methyl)amino}phenyl)formamido]pentanedioic acid (the cas number 59-05-2) at various ionic strengths I of range 0.01–0.4, and at temperatures of 25°C and 37°C, were determined with the use of two different multiwavelength and multivariate treatments of spectral data, SPECFIT32 and SQUAD(84) nonlinear regression analyses and INDICES factor analysis according to a general rule of first, determining the number of components, and then calculating the spectral responses and concentrations of the components. Concurrently, the experimental determination of the thermodynamic dissociation constants was in agreement with its computational prediction of the PALLAS programme based on knowledge of the chemical structures of the drug. The factor analysis in the INDICES programme predicts the correct number of light-absorbing components when the data quality is high and the instrumental error is known. Three thermodynamic dissociation constants were estimated by nonlinear regression of {pK a , I} data: for methotrexate pK a1T= 2.895(13), pK a2T= 4.410(14), pK a3T= 5.726(15) at 25°C and pK a1T= 3.089(15), pK a2T= 4.392(12), pK a3T= 5.585(11) at 37°C, where the figure in brackets is the standard deviation in last significant digits. The reliability of the dissociation constants of the drug were proven by conducting goodness-of-fit tests of the multiwavelength spectrophotometric pH-titration data.
Determination of cobalt in water samples by atomic absorption spectrometry after pre-concentration with a simple ionic liquid-based dispersive liquid-liquid micro-extraction methodology
Authors: Abdolmohammad-Zadeh Hossein , Ebrahimzadeh Elnaz 
Published: March 2010

Abstract
A rapid dispersive liquid-liquid micro-extraction (DLLME) methodology based on the application of 1-hexylpyridinium hexafluorophosphate [C6py][PF6] ionic liquid (IL) as an extractant solvent was applied for the pre-concentration of trace levels of cobalt prior to determination by flame atomic absorption spectrometry (FAAS). 1-Phenyl-3-methyl-4-benzoyl-5-pyrazolone (PMBP) was employed as a chelator forming a Co-PMBP complex to extract cobalt ions from aqueous solution into the fine droplets of [C6py][PF6]. Some effective factors that influence the micro-extraction efficiency include the pH, the PMBP concentration, the amount of ionic liquid, the ionic strength, the temperature and the centrifugation time which were investigated and optimized. In the optimum experimental conditions, the limit of detection (3s) and the enrichment factor were 0.70 µg L−1 and 60, respectively. The relative standard deviation (RSD) for six replicate determinations of 50 µg L−1 Co was 2.36%. The calibration graph using the pre-concentration system was linear at levels 2–166 µg L−1 with a correlation coefficient of 0.9982. The applicability of the proposed method was evaluated by the determination of trace amounts of cobalt in several water samples.
Isomers in the chemistry of mercury coordination compounds
Authors: Melnik Milan 
Published: March 2010

Abstract
The coordination chemistry of mercury is an extremelybroad field, as shown by a survey covering the crystallographic and structural data of over 550 examples. About 12% of those complexes exist as isomers and are summarised and classified in this review. Included are distortion (73%), polymerisation (20.6%), coordination number (3.2%) and ligand (3.2%) isomerism. These are discussed in terms of the coordination around the mercury atoms, and correlations are drawn between donor atoms, bond distances and bond angles. Distortion isomers, differing only by the degree of distortion in the Hg — L and L — Hg — L angles, are the most common. These isomers are discussed and compared with those found in the chemistry of zinc and cadmium.
Theory of reverse scan square-wave voltammetry influenced by the kinetics of reactant adsorption
Authors: Lovrić Milivoj , Komorsky-Lovrić Šebojka 
Published: March 2010

Abstract
A model of electrode reaction complicated by slow adsorption of the reactant is developed for square-wave voltammetry with inverse scan direction. The relationship between the dimensionless net peak current and the logarithm of dimensionless rate constant of adsorption is a curve with a minimum and a maximum. For this reason the ratio of real net peak current and the square-root of frequency is a non-linear function of the logarithm of frequency and exhibits either a maximum or a minimum. The frequency of extreme serves for the estimation of the rate constant: log(k ads /D 1/2 ) = log(k*ads )crit + 0.5 log f crit , where (k*ads )crit is a critical dimensionless rate constant of adsorption. Square-wave voltammetry is sensitive to the kinetics of adsorption if k ads 2 cm s−1
Local stability conditions for discrete-time cascade locally recurrent neural networks
Authors: Patan Krzysztof 
Published: March 2010

Local stability conditions for discrete-time cascade locally recurrent neural networksThe paper deals with a specific kind of discrete-time recurrent neural network designed with dynamic neuron models. Dynamics are reproduced within each single neuron, hence the network considered is a locally recurrent globally feedforward. A crucial problem with neural networks of the dynamic type is stability as well as stabilization in learning problems. The paper formulates local stability conditions for the analysed class of neural networks using Lyapunov's first method. Moreover, a stabilization problem is defined and solved as a constrained optimization task. In order to tackle this problem, a gradient projection method is adopted. The efficiency and usefulness of the proposed approach are justified by using a number of experiments.
On classification with missing data using rough-neuro-fuzzy systems
Authors: Nowicki Robert 
Published: March 2010

On classification with missing data using rough-neuro-fuzzy systemsThe paper presents a new approach to fuzzy classification in the case of missing data. Rough-fuzzy sets are incorporated into logical type neuro-fuzzy structures and a rough-neuro-fuzzy classifier is derived. Theorems which allow determining the structure of the rough-neuro-fuzzy classifier are given. Several experiments illustrating the performance of the roughneuro-fuzzy classifier working in the case of missing features are described.
On the convergence of the wavelet-Galerkin method for nonlinear filtering
Authors: Nowak Łukasz , Pasławska-Południak Monika , Twardowska Krystyna 
Published: March 2010

On the convergence of the wavelet-Galerkin method for nonlinear filteringThe aim of the paper is to examine the wavelet-Galerkin method for the solution of filtering equations. We use a wavelet biorthogonal basis with compact support for approximations of the solution. Then we compute the Zakai equation for our filtering problem and consider the implicit Euler scheme in time and the Galerkin scheme in space for the solution of the Zakai equation. We give theorems on convergence and its rate. The method is numerically much more efficient than the classical Galerkin method.
Two implementations of the preconditioned conjugate gradient method on heterogeneous computing grids
Authors: Collignon Tijmen , Van Gijzen Martin 
Published: March 2010

Two implementations of the preconditioned conjugate gradient method on heterogeneous computing gridsEfficient iterative solution of large linear systems on grid computers is a complex problem. The induced heterogeneity and volatile nature of the aggregated computational resources present numerous algorithmic challenges. This paper describes a case study regarding iterative solution of large sparse linear systems on grid computers within the software constraints of the grid middleware GridSolve and within the algorithmic constraints of preconditioned Conjugate Gradient (CG) type methods. We identify the various bottlenecks induced by the middleware and the iterative algorithm. We consider the standard CG algorithm of Hestenes and Stiefel, and as an alternative the Chronopoulos/Gear variant, a formulation that is potentially better suited for grid computing since it requires only one synchronisation point per iteration, instead of two for standard CG. In addition, we improve the computation-to-communication ratio by maximising the work in the preconditioner. In addition to these algorithmic improvements, we also try to minimise the communication overhead within the communication model currently used by the GridSolve middleware. We present numerical experiments on 3D bubbly flow problems using heterogeneous computing hardware that show lower computing times and better speed-up for the Chronopoulos/Gear variant of conjugate gradients. Finally, we suggest extensions to both the iterative algorithm and the middleware for improving granularity.