bluuebunny/crossref_metadata_2025_split huggingface dataset:
INTerpath-001: Pembrolizumab with V940 (mRNA-4157) versus pembrolizumab with placebo for adjuvant treatment of high-risk stage II-IV melanoma.
Authors: Weber Jeffrey S. , Luke Jason J. , Carlino Matteo S. , Khattak Muhammad Adnan , Meehan Robert S. , Brown Michelle , Zhang Jinchun , Krepler Clemens , Duic J Paul , Long Georgina V. 
Published: June 2024

TPS9616 Background: The anti−PD-1 antibody pembrolizumab is approved as adjuvant therapy for stage IIB-C and stage III melanoma by AJCC 8th ed, following complete resection. Adjuvant pembrolizumab has improved recurrence-free survival (RFS) and distant metastasis-free survival (DMFS) in patients with high-risk melanoma, but many patients experience disease recurrence. In the randomized phase 2b KEYNOTE-942 study, the individualized neoantigen therapy V940 showed improved RFS and DMFS when used in combination with pembrolizumab versus pembrolizumab monotherapy in patients with stage III or IV melanoma. INTerpath-001 (NCT05933577) is a double-blind phase 3 randomized controlled trial designed to evaluate the efficacy and safety of adjuvant pembrolizumab plus V940 versus pembrolizumab plus placebo in patients with resected high-risk stage II-IV melanoma. Methods: Eligible patients are aged ≥18 years with surgically resected stage IIB or IIC (pathologic or clinical), III, or IV cutaneous melanoma per AJCC 8th ed and an Eastern Cooperative Oncology Group performance status of 0 or 1. Patients are ineligible if they have received any prior systemic therapy and if more than 13 weeks has elapsed between last surgical resection and first dose of pembrolizumab. Patients with ocular or mucosal melanoma and past or current in-transit metastases or satellitosis are excluded. All patients must provide a blood sample and a formalin-fixed, paraffin-embedded tumor sample for sequencing. Patients will be stratified by risk (IIB, IIC, IIIA, and IIIB vs IIIC/D and IV) and age (<65 years vs ≥65 years). Approximately 1089 patients will be randomly assigned 2:1 to receive pembrolizumab 400 mg plus V940 1 mg or pembrolizumab 400 mg with placebo. Pembrolizumab will be administered intravenously every 6 weeks and v940 or placebo will be administered intramuscularly every 3 weeks. Treatment will continue for up to 9 doses or until disease recurrence, unacceptable toxicity, or patient withdrawal. The primary end point is RFS by investigator review. Secondary end points are DMFS by investigator review, overall survival, safety and tolerability, and quality of life. Hazard ratios and 95% CIs will be estimated using a stratified Cox regression model with the Efron method of handling ties. Between-treatment differences will be evaluated using a stratified log-rank test. Enrollment is ongoing. Clinical trial information: NCT05933577 .
TRICK-MCC: A proof-of-concept, investigator-initiated study of combination therapy with anti–PD-1, anti–LAG-3, and anti–TIM-3 in participants with advanced or metastatic PD-(L)1 refractory Merkel cell carcinoma.
Authors: Miller Natalie J. , Ambrazeviciute Grete , Chen Wenwen , Dakhil Sumia N , Gaylord Erica , Hall Evan Thomas , Majovski Julia , Herrin Zachary , Kiriluk Samantha , Nghiem Paul , Nguyen Vivian , Perdue Andrea , Pulliam Thomas , Tachiki Lisa May Ling , Veatch Joshua , Bhatia Shailender 
Published: June 2024

TPS9618 Background: Merkel cell carcinoma (MCC) is an aggressive and highly immunogenic skin cancer often associated with the Merkel cell polyomavirus (MCPyV). Immune checkpoint inhibition (ICI) via PD-(L)1 blockade can promote durable responses among patients with metastatic MCC, yet >50% of MCC patients experience disease progression. There is an unmet need for effective treatment options for these patients. One possible strategy to overcome primary and secondary resistance in PD-(L)1 refractory MCC is concurrent targeting of multiple immune checkpoints to facilitate reversal of chronic T cell exhaustion. Based on our preliminary data revealing high expression of PD-1, LAG-3 and TIM-3 on MCC-specific CD8 T cells, which appear to increase upon clinical disease progression in the context of treatment with PD-(L)1 blockade, we hypothesize that concurrent blockade of PD-1, LAG-3 and TIM-3 will overcome immune evasion in patients with PD-(L) refractory MCC. Methods: TRICK-MCC (Triple Immune Checkpoint Inhibition in MCC) is an investigator initiated, Phase 2 clinical trial investigating concurrent treatment with anti-PD-1 (retifanlimab), anti-LAG3 (INCAGN02385) and anti-TIM-3 (INCAGN02390) in patients with advanced/metastatic MCC that has progressed after treatment with anti-PD-(L)1. Target enrollment is 20 patients total, with 5 patients enrolled as of Jan 2024. Patients will receive anti-PD-1 q4w and anti-TIM-3 and LAG-3 q2w for up to 24 weeks (Induction Phase) followed by all drugs q6w (Maintenance Phase). Treatment will end 2 years after starting the study drugs, or upon disease progression, unacceptable toxicity, or study withdrawal. Primary objective is objective response rate (ORR). Secondary objectives are duration of response, progression free survival, overall survival, and incidence and severity of adverse events. Interim analysis will be done after 10 patients have been enrolled and followed sufficiently long to assess ORR. An observed ORR of 25%will be considered as clinically meaningful in this population with no reliable standard treatments. Serial tumor biopsies and blood samples will be obtained in all patients, unless deemed unsafe or not feasible. Planned correlative studies aim to better characterize the prevalence and significance of cancer-specific T cell exhaustion (through rigorous study of MCPyV-specific T cells), the immunologic effects of triple ICI, and alternative mechanisms of PD-(L)1 resistance beyond T cell exhaustion in PD-(L)1 resistant tumors. We hope to gain insights that are broadly applicable to solid tumor immunotherapy. Clinical trial information: NCT06056895 .
Approach to Bone Health in the Patient With Breast Cancer
Authors: Motlaghzadeh Yasaman , Wu Joy Y 
Published: June 2024

Abstract
Treatment for breast cancer, including endocrine therapies, can contribute to bone loss and increase the risk of osteoporosis and fractures. Management of bone health in patients with cancer is often coordinated between oncologists, endocrinologists, and primary care physicians. In this article, we discuss the approach to screening for fracture risk among patients initiating treatments for breast cancer and recommendations for lifestyle modifications to optimize bone health. We will review 3 indications for pharmacologic bone-targeted therapies: prevention of cancer treatment-induced bone loss, adjuvant therapy to reduce recurrence, and management of bone metastases.
Revealed Privacy Preferences: Are Privacy Choices Rational?
Authors: Lee Yi-Shan , Weber Roberto A. 
Published: June 2024

We investigate the extent to which trade-offs involving the sharing of personal information exhibit consistency with an underlying rational preference for privacy. In an experiment, people engage in trade-offs across two domains of personal information sharing, allowing us to classify whether their choices satisfy the generalized axiom of revealed preference. They also subsequently price the sharing of their personal information. Sixty-three percent of subjects act consistently with a rational preference ordering when allocating privacy levels, a level comparable to that observed in other domains. Individuals who are inconsistent when engaging in simple privacy trade-offs exhibit substantially more costly preference reversals when pricing personal information sharing. Only one-third of subjects exhibit consistency across both the selection of personal information to share and the pricing of such information sharing. Our results imply that monetizing personal information can have distinct welfare consequences for people with different degrees of rationality in their underlying ability to make sensible trade-offs involving personal information. We also provide evidence that preferences elicited over choices in our experiment correlate with real-world privacy behaviors. This paper was accepted by Yan Chen, behavioral economics and decision analysis. Funding: This work was supported by Forschungskredit (University of Zurich) [Grant FK-17-017] and Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung [Grant 174630] to Y.S. Lee. Supplemental Material: The online appendix and data files are available at https://doi.org/10.1287/mnsc.2022.00807 .
Symmetrical dual-D and dual-core single-mode fiber surface plasmon resonance liquid sensor
Authors: Xu Rong , Li Xianli , Liu Wei , Lv Jingwei , Yang Lin , Wang Jianxin , Liu Qiang , Chu Paul K. , Liu Chao 
Published: June 2024

A symmetrical dual-D and dual-core single-mode fiber surface plasmon resonance (SPR) liquid sensor is designed for biological detection. The dual-core design optimizes the transmission path, improves the momentum matching between free electrons and photons, and facilitates bidirectional coupling, consequently amplifying the SPR effect and enabling sensitive monitoring of the refractive index changes of biological solutions. In this structure, a gold wire is placed in the middle of the polished surface of the double-D-shaped single-mode fiber (SMF) to produce high-quality free electrons and promote the mode-coupling excitation of the SPR effect. The characteristics of the sensor are analyzed by the finite element method, and the important structural parameters are optimized systematically. The sensor can be operated in the near-infrared region for a refractive index (RI) range of 1.31–1.40 with a maximum wavelength sensitivity (WS) of 21,000 nm/RIU, amplitude sensitivity of 586.62RIU−1, as well as resolution of 4.76×10−6RIU. Small changes in the refractive index can be detected by the sensor and it can be produced easily by conventional manufacturing techniques. The sensor thus has wide application prospects in biomedical and chemical analysis and related applications.
Sildenafil amplifies calcium influx and insulin secretion in pancreatic β cells
Authors: Murao Naoya , Morikawa Risa , Seino Yusuke , Shimomura Kenju , Maejima Yuko , Yamada Yuichiro , Suzuki Atsushi 
Published: June 2024

AbstractSildenafil, a phosphodiesterase‐5 (PDE5) inhibitor, has been shown to improve insulin sensitivity in animal models and prediabetic patients. However, its other metabolic effects remain poorly investigated. This study examines the impact of sildenafil on insulin secretion in MIN6‐K8 mouse clonal β cells. Sildenafil amplified insulin secretion by enhancing Ca2+ influx. These effects required other depolarizing stimuli in MIN6‐K8 cells but not in KATP channel‐deficient β cells, which were already depolarized, indicating that sildenafil‐amplified insulin secretion is depolarization‐dependent and KATP channel‐independent. Interestingly, sildenafil‐amplified insulin secretion was inhibited by pharmacological inhibition of R‐type channels, but not of other types of voltage‐dependent Ca2+ channels (VDCCs). Furthermore, sildenafil‐amplified insulin secretion was barely affected when its effect on cyclic GMP was inhibited by PDE5 knockdown. Thus, sildenafil stimulates insulin secretion and Ca2+ influx through R‐type VDCCs independently of the PDE5/cGMP pathway, a mechanism that differs from the known pharmacology of sildenafil and conventional insulin secretory pathways. Our results reposition sildenafil as an insulinotropic agent that can be used as a potential antidiabetic medicine and a tool to elucidate the novel mechanism of insulin secretion.
Nests of limit cycles in quadratic systems
Authors: Zegeling André 
Published: June 2024

Abstract
We give a proof of the distribution property of limit cycles in so-called quadratic systems. We prove that the possible limit cycle distributions are either

(

n
,
0

)

\left(n,0)

or

(

n
,
1

)

\left(n,1)

(where

n
∈

{

0

}

∪
N

n\in \left\{0\right\}\cup {\mathbb{N}}

). The aim of this article is to simplify and fill gaps in the original proof by Zhang (On the distribution and number of limit cycles for quadratic systems with two foci, Qual. Theory Dyn. Sys. 3 (2002), 437–463). The sixteenth Hilbert problem asks for an upper bound for the number of limit cycles in polynomial systems

H

(

n

)

H\left(n)

, where

n

n

is the maximum degree of the polynomial defining the system. A consequence of the distribution property is that it reduces the study of

H

(

2

)

H\left(2)

to the study of the maximum number of limit cycles surrounding one singularity.
Building words from chemical elements: a fun and inclusive approach to introduce the periodic table
Authors: Limpanuparb Taweetham , Chiranon Weerapat , Intaraprasit Methin 
Published: June 2024

Abstract
A program for writing words (or personal names) by combining chemical element symbols is developed in the context of classroom activity to introduce the periodic table, properties of elements, and periodic trends. We provide multiple examples and possible ideas to improve student engagement and create an inclusive environment in the classroom. Common confusions and mistakes made when learning the periodic table are tabulated and discussed. In addition to spelling words and creating graphics using element symbols, the program can display and print out properties of elements as part of the word-building game.
Zur Ambivalenz von ‚Werten‘ in Diskussionen zur Klima- und Umweltethik
Authors: Düwell Marcus 
Published: June 2024

Abstract
In environmental ethics, many approaches are searching for a justification of the protection of nature and biodiversity via an account of the intrinsic or inherent value of non-human nature, i. e. a justification that does not rely on the perspective of human beings. This leads to intricate problems regarding value theory. This paper proposes to avoid those problems by investigating explicitly anthropocentric pathways. It discusses what kinds of reasons for the protection of nature can be developed from the consistent practical self-understanding of agents. First, it is argued that the practical commitments of agents necessarily involve some normative commitments to the protection of the generic conditions of agency, which are particularly relevant for the ecological conditions that enable us to act and to realise goals. Second, it is discussed whether the presence of non-human nature is particularly relevant from the perspective of philosophical anthropology. Is it not important for human beings to experience non-human nature as an environment that is not fully planned and designed by human beings? The general aim is to show that it is worthwhile to search for justifications of the protection of nature and biodiversity from the practical self-understanding of human beings.
Towards equitable multilingualism: promoting transdisciplinary, collaborative dialogue between English as a lingua franca and translingualism
Authors: Matsumoto Yumi , Kimura Daisuke 
Published: June 2024

Abstract
Inspired by Hult’s (2010. Theme-based research in the transdisciplinary field of educational linguistics. In Francis M. Hult (ed.), Directions and prospects for educational linguistics, 19–32. Springer) discussion of theme-based research within educational linguistics that focuses, first and foremost, on solving problems rather than adhering to disciplinary boundaries and conventions, this article calls for transdisciplinary collaboration to resolve educational problems related to monolingualism, native-speakerism, and the hegemony of colonial ideologies. More specifically, we make a case for transdisciplinary dialogue between English as a lingua franca (ELF) and translingualism. We argue that these two research fields, with their increasingly converging interests and goals as well as distinct strengths, can make a greater impact in addressing persistent educational problems through targeted collaboration, research, and (language) pedagogy based on equitable multilingualism (e.g., Ortega, Lourdes. 2019. SLA and the study of equitable multilingualism. The Modern Language Journal 103. 23–38). In this conceptual paper, we first introduce translingualism and ELF as equally legitimate multilingual theories. Next, we identify shared key tenets and orientations as well as distinctive vantage points of each approach that researchers and educators can take advantage of for collaboratively addressing problems within classrooms and beyond. Finally, we lay out a vision for how this transdisciplinary, collaborative dialogue can help realize more equitable multilingualism.
Verfasserverweise und Typen wissenschaftssprachlichen Handelns: Eine vergleichende Korpusstudie anhand deutscher und polnischer Abschlussarbeiten
Authors: Matthies Jochen 
Published: June 2024

Abstract
Der Artikel beschäftigt sich mit verschiedenen Typen von Verfasserverweisen in wissenschaftlichen Texten und ihrer formalen Realisierung in verschiedenen wissenschaftskulturellen Kontexten. Es wird zwischen Textverweisen, Methodikverweisen und Eristikverweisen unterschieden. Auf dieser Grundlage wird eine Korpusstudie mit deutschsprachigen Abschlussarbeiten auf Bachelor-, Master- und Promotionsniveau vorgenommen. Die Texte stammen jeweils zur Hälfte aus Deutschland und Österreich und zur Hälfte aus Polen. Es zeigt sich, dass die drei unterschiedenen Verweistypen mit klar unterscheidbaren sprachlichen Mustern korrelieren. Diese Muster liegen in den L1-Arbeiten über die Niveaus hinweg relativ konstant vor. Der L2-Sprachgebrauch nähert sich diesen Mustern mit steigendem Qualifikationsniveau an. Ein Vergleich mit polnischsprachigen Doktorarbeiten deutet zudem darauf hin, dass sich Abweichungen in der sprachlichen Realisierung von Verfasserverweisen teilweise auf den Einfluss der polnischen Sprache beziehungsweise Wissenschaftskultur zurückführen lassen.
Isolation of stilbenoids from fresh knotwood of Scots pine using a high yield method
Authors: Saadabadi Atefeh , Korotkova Ekaterina , Eklund Patrik C. 
Published: June 2024

Abstract
Scots pine knotwood contains valuable amount of stilbenoids such as pinosylvin (Ps) and pinosylvin monomethyl ether (PsMME). The stilbenoids have numerous biological activities. Traditional methods of extracting stilbenoids often yield low quantities and involve complex processes. In the present study, a simple and high-yield method was proposed for the extraction of stilbenoids from fresh Scots pine knotwood using ethanol taking a total of three days. In addition, the impact of drying process, extraction time, extraction solvents (acetone and ethanol) and storage time were evaluated on the yield of the stilbenoids. The increased yield and improved extraction efficiency make this method a promising advancement for promoting the utilization of stilbenoids for their valuable bioactive properties.
Termites and Rough Theatre
Authors: Phillips M. Scott 
Published: June 2024

Poet and art critic David Antin observed that, to a great degree, video art derives significance from its relation to some aspect of television. This article acknowledges this and examines video art in the context of a cultural critique via a distinctive mixture of cross-disciplinary collaborations within the arts during the latter half of the twentieth century.
While the video art Antin described can be considered an extension of the postwar recalibration of the emphasis placed on art as object, it was also the beneficiary of early twentieth-century experimentation, such as Dada’s challenge to notions of art and expectations regarding aesthetics, as well as early experimentation in cinema. This intersection of culture and art histories finds its way into the early video work of Daniel Boord.
My main interest in Boord’s work is its relation to experimentation with theatricality, an area not usually associated with video art. Boord’s “lowbrow” absence of pretense and disregard for reductive formalism align well with Peter Brook’s conception of the “Rough Theatre,” as well as film critic Manny Farber’s notion of “termite art,” art that “feels its way through walls of particularization” and eats at its own boundaries. Boord’s work is a self-propelled dizzying array of humor, ideas, and juxtapositions that are well suited for the twentieth century—work that moves along according to its own self-defined boundaries of invention.
Giant Gallstones – a Systematic Review
Authors: Alkhezzi Amjaad , Salati Sajad Ahmad , Alsulaim Lamees Sulaiman , Elmuttalut Mohammad Ahmed , Alsalamah Yasir Ahmed 
Published: June 2024

Giant gallstones are rare occurrences and measure 5 cm in any one dimension. They present unique set of features and complications. Due to their rarity, we conducted this systematic review to investigate the profile of patients with giant gallstones applying seven variables. For this study, we used the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines. After an initial search of 111 peer reviewed articles from reliable sources, we included 29 articles for this study enrolling 30 patients with mean age of 66.7 years. Majority (97%) were symptomatic, reporting with cholecysto-enteric fistula/gallstone ileus (33%), acute cholecystitis (30%) and chronic dyspepsia (24%). The management options adopted included open cholecystectomy (48%), laparoscopic cholecystectomy (33%), endoscopic lithotripsy (6%) and conservative management (6%).
Phytoecological study of a Biosphere Reserve in arid climate in Tunisia
Authors: Rouissi Alaeddine , Ezzine Olfa , Yangui Islem , Nouainia Walid , Zouaoui Refka , Ammari Youssef 
Published: June 2024

Anthropic effects and global change threaten biodiversity and genetic resources. Thus, their conservation becomes a primary necessity. This work aims to assess the conservation conditions for vegetation and causes that limit the progressive dynamics of the vegetation cover after a long period of defense. Using the quadrat point method, his work was conducted in two fenced zones and an unfenced zone of the Biosphere Reserve of BouHedma in a Tunisian arid climate. A total of 66 transects were investigated. In each transect species richness and, α and β indices were determined. The α and β diversity showed a low similarity in family and species composition in the studied zones. The Poaceae and Asteraceae families were the most representative in the studied zones and the most used for grazing. These results highlight that long-term conservation contributes to minimizing the reduction of biodiversity in the reserve. It is necessary to minimize razing and deforestation, especially in the unfenced zone. Thus, the setup of barriers and fences is highly recommended to retain the soil. In addition, finding an effective communication plan with the local population and visitors seems to be crucial.