bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pengaruh budaya organisasi, lingkungan kerja dan kompensai terhadap kinerja karyawan hotel insumo palace
Authors: Putra Mifta Wahyu , Dewi Anita Sumelvia , Syahputra Erwin 
Published: April 2024

Penelitian ini bertujuan untuk mengetahui: (1)pengaruh Budaya Organisasi terhadap Kinerja Karyawan, (2) pengaruh Lingkungan Kerja terhadap Kinerja Karyawan, (3) pengaruh Kompensasi terhadap Kinerja Karyawan (4)pengaruh Budaya Organisasi, Lingkungan Kerja dan Kompensasi terhadap Kinerja Karyawan. Jenis penelitian ini menggunakan pendekatan kuantitatif. Sampel penelitian ini adalah Karyawan Hotel Insumo Palace Kediri sebanyak 60 responden. Teknik pengambilan sampel menggunakan purposive sampling. Teknik pengumpulan data menggunakan kuesioner yang telah diuji validitas dan reliabilitasnya. Teknik analisis data yang digunakan adalah regresi linier berganda. Hasil penelitian pada taraf signifikansi 5% menunjukkan bahwa: (1) tidak terdapat pengaruh secara parsial dan signifikan Budaya Organisasi terhadap Kinerja Karyawan. Nilai sig 0,064 > 0,05. (2) terdapat pengaruh secara parsial dan signifikan Lingkungan Kerja terhadap Kinerja Karyawan. Nilai sig 0,000 < 0,05. (3) terdapat pengaruh secara parsial dan signifikan Kompensasi terhadap Kinerja Karyawan. Nilai sig 0,000 < 0,00. (4) terdapat pengaruh Masa kerja, Lingkungan Kerja dan Employee Engagement secara simultan terhadap Kinerja Karyawan. Nilai sig 0,000 < 0,05. persamaan regresi diperoleh dengan nilai
Y = 4,249 +(- 0,384)X1 + 0,93X2 + 1,595X3
Kata kunci : Budaya Organisasi, Lingkungan Kerja, Kompensasi dan Kinerja.
Pengaruh Program Pelatihan dan Pengembangan Karyawan terhadap Kinerja Karyawan (Studi Kasus pada PT. Astra Internasional Tbk. AUTO 2000 Cabang Malang Sutoyo)
Authors: Saifuddin Muhammad , Erna Resmiatini  
Published: April 2024

Pada penelitian ini, penulis bermaksud untuk melakukan pengujian pengaruh terkait program pelatihan dan pengembangan karyawan terhadap kinerja karyawan PT. Astra Internasional Tbk., AUTO2000 Cabang Malang Sutoyo. Data dikumpulkan menggunakan angket yang disebarkan kepada 50 karyawan bagian service. Pengujian dilakukan dengan metode kuantitatif, khususnya analisis regresi berganda. Hasil penelitian menunjukkan bahwa secara parsial program pelatihan tidak memiliki pengaruh terhadap kinerja karyawan. Berbeda dengan program pengembangan yang terbukti dapat mempengaruhi kinerja karyawan secara positif dan signifikan. Meski demikian, secara simultan, program pelatihan dan pengembangan karyawan yang telah dilakukan oleh PT. Astra Internasional Tbk., AUTO2000 Cabang Malang Sutoyo di bagian service terbukti dapat mempengaruhi kinerja karyawan.
Kata kunci: Pelatihan, Pengembangan, Kinerja Karyawan.
Strategi Pengembangan Program Kawasan Rumah Pangan Lestari (KRPL) Di Desa Rejosari Kecamatan Bantur
Authors: Amaliya Angguliyah Rizqi , Yenie Eva Damayanti  , Miftahuljannah Fitriani 
Published: April 2024

Kawasan Rumah Pangan Lestari (KRPL) merupakan konsep optimalisasi pemanfaatan lokasi pekarangan di sekitar rumah dengan berbagai tanaman. Tujuan penelitian ini adalah untuk mengetahui factor internal dan eksternal serta menentukan strategi pengembangan program Kawasan rumah pangan lestari (KRPL) di Desa Rejosari Kecamatan Bantur. Analisis program pengembangan strategi (KRPL) di Desa Rejosari Kecamatan Bantur menggunakan analisis SWOT. Model yang direkomendasikan untuk pengembangan program KRPL berdasarkan pada hasil pengkajian dan analisis potensi sumber daya alam dan lingkungan serta potensi KRPL yang diintegrasikan dengan analisis aspek social ekonomi, perlindungan dan kemitraan pengembangannya. Hasil analisis factor internal program KRPL yaitu antara lain; a.Kekuatan (posisi geografis KRPL, dekat dengan penyedia input produksi dan konsumen) b.Kelemahan (SDM), pengelola dan pendampingan, pengaruh hama dan penyakit, dan pemanfaatan teknologi dalam pelaksanaan KRPL. Sedangkan factor eksternal program KRPL yaitu antara lain; a.Peluang (kebijakan dalam mengembangkan program KRPL, infrastruktur pendukung, dan kinerja dan kapasitas keselamatan), b.Ancaman (kenaikan harga produk lain dan perubahan cuaca). Program peningkatan strategi prioritas KRPL dapat dilakukan dengan cara meningkatkan tabungan dengan meningkatkan kesesuaian, mengoptimalkan fungsi pekarangan untuk meningkatkan jumlah produksi, meningkatkan posisi tawar KRPL dengan menyediakan produk berkualitas untuk keuntungan, dan memasarkan produk dengan memanfaatkan produk yang ada.
Kata Kunci: Strategi, Pengembangan, Program KRPL
PELATIHAN PENGELOLAAN KEUANGAN KELUARGA PADA MASYARAKAT DESA PURWODADI KABUPATEN MALANG
Authors: Ika Ika Rinawati , M. Yusuf Azwar Anas 
Published: April 2024

Proper family financial management can create a healthy family financial condition so that the family avoids a financial deficit. Finance with this healthy condition is a financial condition that is able to bear the needs of both current needs and future needs, because we never know what calamities will occur in the future as well as the need for emergency costs that we must spend. The methods used in this PkM activity are socialization, training and participant surveys. The results of this PkM activity show that the people of Purwodadi village are very enthusiastic and willing to implement financial management in every family need. In addition to the ability to arrange structured management, the community is also able to carry out financial evaluations at the end of the month, this is done to see if the financial condition of their families is healthy or not. So that the financial holder, in this case the housewife, can determine the follow-up steps to improve the financial health of her family
Keywords: Training ; Financial Management ; Family
PENGUATAN MODEL POLA ASUH DALAM MENGEMBANGKAN KARAKTER ISLAMI PADA ANAK MELALUI KEGIATAN PARENTING GURU DAN ORANG TUA DI TK, PAUD DAN SD DESA NGABAB KECAMATAN PUJON KABUPATEN MALANG
Authors: Rohmah Noer , Djunaidi Djunaidi 
Published: April 2024

Pola asuh adalah cara orang tua bertindak sebagai suatu aktivitas kompleks yang melibatkan banyak perilaku spesifik secara individu atau bersama-sama sebagai serangkaian usaha aktif untuk mengarahkan anaknya. Serangkaian kegiatan meliputi cara penerapan aturan, mengajarkan nilai / norma, memberikan perhatian dan kasih sayang serta menunjukkan sikap dan perilaku baik.Program pengabdian masyarakat ini berfokus pada penguatan model pola asuh melalui kegiatan pendampingan guru dan orang tua di TK, PAUD dan SD desa Ngabab Kecamatan Pujon Kabupaten Malang.
Fokus dan tujuan kegiatan mencakup ; (1) model pola asuh yang baik dan benar, (2) model pembelajaran yang efektif bagi guru, (3) Pembiasaan hidup sehat dan ramah lingkungan, (4) faktor yang mempengaruhi pertumbuhan dan perkembangannya.
Program yang sudah dilakukan dalam kegiatan pendampingan antara lain : 1).Seminar parenting model pola asuh orang tua dan guru; 2). Penyuluhan dan dialog tentang model pembelajaran aktif, interaktif dan menyenangkan; dan 3).Penyuluhan dan dialog tentang pemanfaatan lingkungan.
Adapun hasil dari program pengabdian diantaranya yaitu: 1). Meningkatnya pemahaman orang tua dan guru tentang model pola asuh yang baik dan benar; 2). Meningkatnya pemahaman orang tua tentang fase-fase pertumbuhan dan perkembangan anak, dan 3). Meningkatnya pemahaman orang tua akan pentingnya lingkungan sebagai sumber belajar yang efektif
Melestarikan Budaya Jawa di Desa Ngawonggo melalui Kegiatan Ngangsu Budaya
Authors: Rizki Moh. Farid Khalifatur , Fawziah Zahro Qorina , Wiladiyah Azka Firda , Sinollah Sinollah 
Published: April 2024

Kegiatan ini bertujuan untuk mengkonsep kampung Jawa di Desa Ngawonggo yang berfokus pada penggunaan bahasa Jawa krama dalam kehidupan sehari-hari. Kegiatan ini dilakukan melalui observasi dan wawancara, sosialisasi, pembangunan tempat edukasi hingga FGD pada gelaran ngangsu budaya. Hasil dari diskusi pada gelaran ngangsu budaya yang telah diselenggarakan sangat mendapat respon positif dari pihak pemerintah desa, pengelola situs petirtaan dan warga setempat. Dengan adanya diskusi terbuka yang dilakukan dengan ngaji budaya membuka akses kedepannya untuk pihak pemerintah desa untuk bekerjasama melestarikan dan mengembangkan situs petirtaan Ngawonggo. Ngangsu budaya dilakukan dengan gelaran : Festival dolanan, ngangsu banyu, diskusi budaya dengan mendatangkan Staff Ahli Kemendikbud. Kegiatan ini juga menambah wawasan pada warga betapa pentingnya menjaga peninggalan sejarah di desa mereka, serta mengetahui usaha-usaha apa saja yang dapat dilakukan untuk menjaga kekayaan sejarah di desa mereka
Pemanfaatan Bahan Alami Sebagai Hand Sanitizer Pada Masyarakat Desa Sepanjang Kecamatan Gondanglegi-Malang
Authors: Amaliyah Angguliyah Rizqi , Farid Muhammad , Vivin Tri Kurniasari  , Masduhan Khoiri  
Published: April 2024

Hand Sanitizer merupakan salah satu bahan antiseptic berupa gel yang sering digunakan oleh banyak orang sebagai media cuci tangan yang higienis dan praktis. Hand Sanitizer dapat digunakan kapan saja dan dimana saja untuk mencegah penyebaran virus Covid-19 dan menerapkan protokol Kesehatan. Tujuan dari kegiatan ini untuk mengedukasi dan meningkatkan pengetahuan dan kemampuan masyarakat tentang pentingnya mencegah penyebaran Virus Corona (Covid-19) dimasa pandemi. Pengabdian ini menggunakan pendekatan Asset Based Community Development (ABCD). Pendekatan ABCD merupakan pendekatan yang mengarah pada pemahaman dan internalisasi asset, kekuatan, potensi dan pendayagunaan secara mandiri dan maksimal. Kesimpulan yang diperoleh dari kegiatan pengabdian ini terdapat peningkatan pengetahuan dan keterampilan masyarakat Desa Sepanjang Kecamakan Gondanglegi-Malang tentang cara pembuatan Hand Sanitizer dari bahan alami sehingga dapat mengurangi biaya pengeluaran tambahan untuk pembelian produk Hand Sanitizer sendiri dalam menanggulangi penyebaran Virus Covid-19.
Kata Kunci: Bahan Dapur; Plastik Daur Ulang; Media Vertikultur.
Application value of metagenomic next-generation sequencing in hematological patients with high-risk febrile neutropenia
Authors: Wang Xiao , Zhang Huiye , Zhang Nan , Zhang Shan , Shuai Yanrong , Miao Xiaojuan , Liu Yilan , Qiu Ling , Ren Shihui , Lai Sihan , Han Ying , Yao Hao , Zhang Xupai , Fan Fangyi , Sun Haoping , Yi Hai 
Published: April 2024

BackgroundMetagenomic next-generation sequencing (mNGS) is a novel non-invasive and comprehensive technique for etiological diagnosis of infectious diseases. However, its practical significance has been seldom reported in the context of hematological patients with high-risk febrile neutropenia, a unique patient group characterized by neutropenia and compromised immune responses.MethodsThis retrospective study evaluated the results of plasma cfDNA sequencing in 164 hematological patients with high-risk febrile neutropenia. We assessed the diagnostic efficacy and clinical impact of mNGS, comparing it with conventional microbiological tests.ResultsmNGS identified 68 different pathogens in 111 patients, whereas conventional methods detected only 17 pathogen types in 36 patients. mNGS exhibited a significantly higher positive detection rate than conventional methods (67.7% vs. 22.0%, P &lt; 0.001). This improvement was consistent across bacterial (30.5% vs. 9.1%), fungal (19.5% vs. 4.3%), and viral (37.2% vs. 9.1%) infections (P &lt; 0.001 for all comparisons). The anti-infective treatment strategies were adjusted for 51.2% (84/164) of the patients based on the mNGS results.ConclusionsmNGS of plasma cfDNA offers substantial promise for the early detection of pathogens and the timely optimization of anti-infective therapies in hematological patients with high-risk febrile neutropenia.
Patient perceptions and preferences of minimally invasive treatment modalities in varicose veins: a cross-sectional survey
Authors: Li Qian , Wang Xiaotao , Meng Bin , Chen Xinle , Xu Mingmin 
Published: April 2024

PurposeMinimally invasive therapies (MIT) have gained popularity due to their capacity to reduce trauma, enhance aesthetic outcomes, and shorten recovery periods. This article explores patients’ perceptions and preferences regarding MIT for varicose veins (VVs) while analyzing associated influencing factors to provide a better understanding.Patients and methodsA cross-sectional survey at Zhejiang Rongjun Hospital was performed from January 2022 to June 2023, involving 305 participants with VVs. The questionnaire assessed patient demographics, VVs severity, prior treatment experiences, and treatment preferences. Statistical analyses, including chi-square and Kruskal-Wallis tests, were conducted to explore the correlations between patient characteristics, treatment preferences, and factors influencing these choices.ResultsNearly half of the participants (44.3%) lacked information on any surgical options, whereas a slight majority (55.7%) possessed familiarity with at least one treatment modality, and only 9.8% knew of all six treatment methods presented. Patient surveys discerned that the majority (68.5%) declared an inadequate grasp of treatment methodologies to articulate a treatment preference. Among the 96 patients who made a treatment choice, 24.0% opted for traditional surgery, while 76.0% chose MIT and a higher preference for MIT among male patients compared to female patients (p = 0.006). The patients preferred treatment options for VVs significantly affected by vascular surgeon recommendations and the number of follow-up visits (r = 0.129, p = 0.024; r = 0.122, p = 0.033).ConclusionThe study highlights limited awareness of MIT among Chinese patients with VVs. The insights emphasize the influential role of vascular surgeons’ recommendations and suggest a growing predilection for less invasive treatments due to their advantages in recovery and aesthetics. Provider-patient communication, including education about available treatments and shared decision-making, is essential to align treatment plans with patient expectations and improve outcomes.
Oxidative stress contributes to hypermethylation of Histone H3 lysine 9 in placental trophoblasts from preeclamptic pregnancies
Authors: Gu Yang , Cooper Danielle , Lewis David F. , Zoorob Dani , Wang Yuping 
Published: April 2024

Background and objectiveAberrant epigenetic regulation and increased oxidative stress in the placenta play a significant role in placental pathophysiology and fetal programming in preeclampsia, a hypertensive disorder in human pregnancy. The purpose of the study is to investigate if hypermethylation of histone H3K9 occurs in placental trophoblasts from preeclampsia.MethodsTrophoblasts were isolated and cultured from 14 placentas, 7 from normotensive pregnant women and 7 from preeclamptic pregnancies. Methylated H3K9 expression and antioxidant superoxide dismutase expression were determined by Western blot. We also examined consequences of oxidative stress and the downstream effects of histone methyltransferase inhibition on H3K9 expression associated with antioxidant CuZn-SOD and Mn-SOD expression in placental trophoblasts.ResultsWe found that expression of mono-, di-, and tri-methylation of histone H3 lysine 9 (H3K9me1, H3K9me2 and H3K9me3) was significantly increased, p&lt;0.01, which correlated with downregulation of antioxidant superoxide dismutase CuZn-SOD and Mn-SOD expression, in trophoblasts from preeclamptic placentas compared to those from uncomplicated control placentas. We further demonstrated hypoxia could promote histone H3K9 methylation in placental trophoblasts, and hypoxia-induced upregulation of H3K9me1, H3K9me2 and H3K9me3 expression was reversible when hypoxic condition was removed. In addition, we also uncovered that inhibition of methyltransferase not only prevented hypoxia-induced upregulation of H3K9me1, H3K9me2 and H3K9me3 expression, but also abolished hypoxia-induced downregulation of CuZn-SOD and Mn-SOD expression in placental trophoblasts.ConclusionsThese findings are noteworthy and provide further evidence that increased oxidative stress in the intrauterine environment is likely a mechanism to induce aberrant histone modification in placental trophoblasts in preeclampsia. Moreover, CuZn-SOD and Mn-SOD expression/activity are possibly H3K9 methylation-dependent in placental trophoblasts, which further suggest that oxidative stress and aberrant histone modification have significant impact on placental trophoblasts/fetal programming in preeclampsia.
Issues and paths forward in the identification and reuse of historic analog records
Authors: Anderson Bethany G. , Antognoli Erin , Caldrone Sandi L. , Derner Justin D. , Farrell Shannon L. , Fenlon Katrina , Hendrickson John R. , Hendrickson Lois G. , Johnson Holly A. , Kaplan Nicole E. , Kelly Julia A. , Mastel Kristen L. , Williams Sarah C. 
Published: April 2024

Introduction: Historic data, often in analog format, is a valuable resource for assessing effects of directional changes in climate and climatic variability. However, historic data can be difficult to locate, interpret, and reformat into a useful state.Methods: Teams of scientists, librarians, archivists, and data managers at four US institutions have undertaken various projects to gather, describe, and in some cases, transform historic data. They have also surveyed researchers who either possess historic data or have used it in their work.Results: Historic data projects involved locating data, writing data descriptions, and connecting with individuals who had knowledge about the data’s collection. The surveys and interviews found that researchers valued historic data and were worried that it was at risk of loss. They noted the lack of best practices.Discussion: Each project attempting to rescue or enhance access to historic data has a unique path but being guided by FAIR principles should be at the core whether or not the end result is machine-readable data. Working with a team incorporating librarians, archivists, and data managers can aid individual researchers’ in producing accessible, and reusable datasets. There is much work to be done in raising awareness about the value of historic data but motivating factors for doing so include its usefulness in environmental research and other disciplines and its risk of loss as researchers retire and are unsure of how to save historic data, both in analog and electronic formats.
Clinical characteristics of patients with autoimmune nodopathy with anti-neurofascin155 antibodies
Authors: Zhang Jiwei , Hou Xiaotong , Wei Liting , Liu Jinshun , Li Shibo , Guo Yifan , Liu Hongbo , Jiang Yan 
Published: April 2024

BackgroundAccording to the latest guidelines on chronic inflammatory demyelinating polyradiculoneuropathy (CIDP), patients with CIDP with anti-neurofascin 155 (NF155) antibodies are referred to as autoimmune nodopathy (AN), an autoimmune disorder distinct from CIDP. We aimed to compare the clinical data of patients with AN with anti-NF155 antibodies with those of anti-NF155 antibodies-negative patients with CIDP, and to summarize the clinical characteristics of patients with AN with anti-NF155 antibodies.MethodsNine patients with AN with anti-NF155 antibodies and 28 serologically negative patients with CIDP were included in this study. Diagnosis was made according to the diagnostic criteria in the European Academy of Neurology (EAN)/Peripheral Nerve Society (PNS) guidelines on CIDP published in 2021. Demographics, clinical manifestations, electrophysiological examination, cerebrospinal fluid (CSF) tests, and response to treatment were retrospectively analyzed.ResultsCompared with serologically negative patients with CIDP, those patients with AN with anti-NF155 antibodies were younger (p=0.007), had a younger onset age (p=0.009), more frequent ataxia (p=0.019), higher CSF protein levels (p=0.001), and more frequent axon damage in electrophysiology (p=0.025). The main characteristics of patients with AN with anti-NF155 antibodies include younger age and onset age, limb weakness, sensory disturbance, ataxia, multiple motor−sensory peripheral neuropathies with demyelination and axonal damage on electrophysiological examination, markedly elevated CSF protein levels, and varying degrees of response to immunotherapy.ConclusionsPatients with AN with anti-NF155 antibodies differed from serologically negative patients with CIDP in terms of clinical characteristics. When AN is suspected, testing for antibodies associated with the nodes of Ranvier is essential for early diagnosis and to guide treatment.
Signatures of CD4+ T and B cells are associated with distinct stages of chronic chagasic cardiomyopathy
Authors: Vale Isabela Natália Pascoal Campos do , Almeida Gregório Guilherme , Rimkute Inga , Liechti Thomas , Araújo Fernanda Fortes de , Santos Luara Isabela dos , Henriques Priscilla Miranda , Rocha Manoel Otávio da Costa , Elói-Santos Silvana Maria , Martins−Filho Olindo Assis , Roederer Mario , Sher Alan , Jankovic Dragana , Teixeira−Carvalho Andréa , Antonelli Lis Ribeiro do Valle 
Published: April 2024

IntroductionChagas disease is a neglected parasitic disease caused by Trypanosoma cruzi. While most patients are asymptomatic, around 30% develop Chronic Chagasic Cardiomyopathy (CCC).MethodsHere, we employed high-dimensional flow cytometry to analyze CD4+ T and B cell compartments in patients during the chronic phase of Chagas disease, presenting the asymptomatic and mild or moderate/severe cardiac clinical forms.ResultsEffector CD27-CD4+ T cells were expanded in both CCC groups, and only mild CCC patients showed higher frequencies of effector memory and T follicular helper (Tfh) cells than healthy donors (CTL) and asymptomatic patients. Unsupervised analysis confirmed these findings and further revealed the expansion of a specific subpopulation composed of Tfh, transitional, and central memory CD4+ T cells bearing a phenotype associated with strong activation, differentiation, and exhaustion in patients with mild but not moderate/severe CCC. In contrast, patients with mild and moderate/severe CCC had lower frequencies of CD4+ T cells expressing lower levels of activation markers, suggesting resting status, than CTL. Regarding the B cell compartment, no alterations were found in naïve CD21-, memory cells expressing IgM or IgD, marginal zone, and plasma cells in patients with Chagas disease. However, expansion of class-switched activated and atypical memory B cells was observed in all clinical forms, and more substantially in mild CCC patients.DiscussionTaken together, our results showed that T. cruzi infection triggers changes in CD4+ T and B cell compartments that are more pronounced in the mild CCC clinical form, suggesting an orchestrated cellular communication during Chagas disease.ConclusionOverall, these findings reinforce the heterogeneity and complexity of the immune response in patients with chronic Chagas disease and may provide new insights into disease pathology and potential markers to guide clinical decisions.