bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mass-redshift dependency of supermassive black hole binaries for the gravitational wave background
Authors: Kozhikkal Musfar Muhamed , Chen Siyuan , Theureau Gilles , Habouzit Mélanie , Sesana Alberto 
Published: May 2024

ABSTRACT
Studying how the black hole (BH)–(galaxy) bulge mass relation evolves with redshift provides valuable insights into the co-evolution of supermassive black holes and their host galaxies. However, obtaining accurate measurement of BH masses is challenging due to the bias towards the most massive and luminous galaxies. Instead, we focus on the BH and bulge masses as they vary with redshift using the EAGLE, Illustris, TNG100, TNG300, Horizon-AGN, and SIMBA large-scale cosmological simulations. We use an analytical astrophysical model with galaxy stellar mass function, pair fraction, merger time-scale and BH–bulge mass relation extended to include redshift evolution. The model can predict the intensity of the gravitational wave background (GWB) produced by a population of supermassive black hole binary (SMBHB) as a function of the frequency. This allows us to compare the predictions of this model with the constraints of pulsar timing array observations. Here, we employ Bayesian analysis for the parameter inference. We find that all six simulations are consistent $\le 3.5\sigma$ with a range of simulated GWB spectra. By fixing the BH–bulge mass parameters to the simulations we analyse the changes in the constraints on the other astrophysical parameters. Furthermore, we also examine the variation in SMBHB merger rate with mass and redshift between these large-scale simulations.
An arcsecond view at 1–2 GHz into the Galactic Bulge
Authors: Pattie E C , Maccarone T J , Britt C T , Heinke C O , Jonker P G , Lorimer D R , Sivakoff G R , Steeghs D , Strader J , Torres M A P , Wijnands R 
Published: May 2024

ABSTRACT
We present the results of a high angular resolution (1.1 arcsec) and sensitivity (maximum of ∼0.1 mJy) radio survey at 1–2 GHz in the Galactic Bulge. This complements the X-ray Chandra Galactic Bulge Survey, and investigates the full radio source population in this dense Galactic region. Radio counterparts to sources at other wavelengths can aid in classification, as there are relatively few types of objects that are reasonably detectable in radio at kiloparsec distances, and even fewer that are detected in both X-rays and radio. This survey covers about 3 sq deg of the Galactic Bulge Survey area (spanning the Galactic coordinate range of −3° &lt; l &lt; +3° and +1.6° &lt; b &lt; +2.1°) as a first look into this region of the Galaxy with this combination of frequency, resolution, and sensitivity. Spectral indices within the observed band of 1–2 GHz were calculated for each source to assist in determining its emission mechanism. We find 1617 unique sources in the survey, 25 of which are radio counterparts to X-ray sources, and about 100 of which are steep-spectrum (α ≲ −1.4) point sources that are viable pulsar candidates. Four radio sources are of particular interest: a compact binary; an infrared transient with an inverted radio spectrum; a potential transitional millisecond pulsar candidate; and a very steep spectrum radio source with an X-ray and bright infrared counterpart. We discuss other notable sources, including possible radio transients, potential new planetary nebulae, and active galactic nuclei.
Stress fracture of the clavicle associated with sternocostoclavicular hyperostosis combined with bony ankylosis of the acromioclavicular joint and ossification of the coracoclavicular ligament
Authors: Kurose Rie , Wakai Yuji 
Published: May 2024

ABSTRACT
Sternocostoclavicular hyperostosis (SCCH) has been reported in patients with pustulotic arthro-osteitis, but there are few reports of marked ossification of the lateral part of the clavicle. Here, we report a case of stress fracture in a patient with SCCH with marked ossification of the lateral part of the clavicle. In this case, the clavicular fracture was proximal and no dislocation. Conservative treatment with a clavicle band and the administration of corticosteroids resulted in rapid symptom improvement. Eight months later, the patient had no difficulty in daily life, but X-rays showed that bone fusion was not complete. Therefore, it is necessary to carefully follow-up such patients for any recurrence of symptoms and radiographic changes.
Comparative evaluation of the diagnostic and prognostic performance of CNSide™ versus standard cytology for leptomeningeal disease
Authors: Appel Haley R , Rubens Muni , Roy Mukesh , Kotecha Rupesh , Hall Matthew D , Mehta Minesh P , Mohler Alexander , Chen Zhijian , Ahluwalia Manmeet S , Odia Yazmin 
Published: May 2024

Abstract

Background
This retrospective study compares the real-world performance of cerebrospinal fluid (CSF) CNSide™ versus cytology in leptomeningeal disease (LMD).

Methods
Consecutive patients with suspected LMD who underwent lumbar punctures for CSF cytology and CNSide™ from January 2020 to December 2022 were reviewed. LMD was classified by EANO criteria. Descriptive statistics, confusion matrix, Kaplan–Meier curves, and Cox proportional regression were used.

Results
Median age for 87 evaluable patients was 63 years (range: 23–93); 82 (94%) met EANO criteria for possible/probable/confirmed LMD (EANO/LMD). The commonest primary cancers were breast (36,44.0%) and lung (34,41.5%). Primary lung harbored actionable mutations in 18 (53.0%); primary breast expressed hormone receptors in 27 (75%), and HER2 amplification in 8 (22%). Uncontrolled systemic disease was detected in 35 (40%), while 25 (46%) received systemic therapy with medium/high CNS penetrance at LMD diagnosis. The median time from initial cancer to LMD diagnosis was 31 months (range: 13–73). LMD was confirmed by CSF cytology in 23/82 (28%), all identified by CNSide™. CNSide™ identified 13 additional cases (36/82, 43.9%), increasing diagnostic yield by 56.5%. Median overall survival (mOS) was 31 weeks (95%CI: 21–43), significantly worse for CNSide™ positive versus negative: 4.0 versus 16.0 weeks, respectively (HR = 0.50, P = .010). While survival since LMD diagnosis did not differ by histology, time to LMD diagnosis from initial cancer diagnosis was longer for breast (48.5 months, IQR: 30.0–87.5) versus lung (8 months, IQR:0.5–16.0) cohorts. mOS was longer for patients eligible for intrathecal chemotherapy (HR: 0.189, 95%CI: 0.053–0.672, P = .010).

Conclusions
This retrospective, real-world analysis of CNSide™ showed increased sensitivity versus cytology and provided clinically relevant molecular CSF analyses.
Digital applications for diet monitoring, planning, and precision nutrition for citizens and professionals: a state of the art
Authors: Abeltino Alessio , Riente Alessia , Bianchetti Giada , Serantoni Cassandra , De Spirito Marco , Capezzone Stefano , Esposito Rosita , Maulucci Giuseppe 
Published: May 2024

Abstract
The objective of this review was to critically examine existing digital applications, tailored for use by citizens and professionals, to provide diet monitoring, diet planning, and precision nutrition. We sought to identify the strengths and weaknesses of such digital applications, while exploring their potential contributions to enhancing public health, and discussed potential developmental pathways. Nutrition is a critical aspect of maintaining good health, with an unhealthy diet being one of the primary risk factors for chronic diseases, such as obesity, diabetes, and cardiovascular disease. Tracking and monitoring one’s diet has been shown to help improve health and weight management. However, this task can be complex and time-consuming, often leading to frustration and a lack of adherence to dietary recommendations. Digital applications for diet monitoring, diet generation, and precision nutrition offer the promise of better health outcomes. Data on current nutrition-based digital tools was collected from pertinent literature and software providers. These digital tools have been designed for particular user groups: citizens, nutritionists, and physicians and researchers employing genetics and epigenetics tools. The applications were evaluated in terms of their key functionalities, strengths, and limitations. The analysis primarily concentrated on artificial intelligence algorithms and devices intended to streamline the collection and organization of nutrition data. Furthermore, an exploration was conducted of potential future advancements in this field. Digital applications designed for the use of citizens allow diet self-monitoring, and they can be an effective tool for weight and diabetes management, while digital precision nutrition solutions for professionals can provide scalability, personalized recommendations for patients, and a means of providing ongoing diet support. The limitations in using these digital applications include data accuracy, accessibility, and affordability, and further research and development are required. The integration of artificial intelligence, machine learning, and blockchain technology holds promise for improving the performance, security, and privacy of digital precision nutrition interventions. Multidisciplinarity is crucial for evidence-based and accessible solutions. Digital applications for diet monitoring and precision nutrition have the potential to revolutionize nutrition and health. These tools can make it easier for individuals to control their diets, help nutritionists provide better care, and enable physicians to offer personalized treatment.
Cognitive impairment following breast cancer treatments: an umbrella review
Authors: Oliva Giulia , Giustiniani Andreina , Danesin Laura , Burgio Francesca , Arcara Giorgio , Conte Pierfranco 
Published: May 2024

Abstract

Objectives
Cancer-related cognitive impairment (CRCI) refers to a cognitive decline associated with cancer or its treatments. While research into CRCI is expanding, evidence remains scattered due to differences in study designs, methodologies, and definitions. The present umbrella review aims to provide a comprehensive overview of the current evidence regarding the impact of different breast cancer therapies on cognitive functioning, with a particular focus on the interplay among objective cognitive deficits (ie, measured with standardized tests), subjective cognitive concerns, (ie, self-reported), and other mediating psycho-physical factors.

Methods
The search was made in Pubmed, Embase, and Scopus for articles published until July 2023, following the guidelines of the Preferred Reporting Items for Systematic Reviews and Meta-analysis protocol.

Results
Chemotherapy and endocrine therapy appear consistently associated with CRCI in patients with breast cancer, primarily affecting memory, attention/concentration, executive functioning, and processing speed. Subjective cognitive concerns were often found weakly or not associated with neuropsychological test results, while overall CRCI seemed consistently associated with psychological distress, fatigue, sleep quality, and inflammatory and biological factors.

Conclusion
Current evidence suggests that CRCI is common after chemotherapy and endocrine therapy for breast cancer. However, heterogeneity in study designs and the scarcity of studies on more recent treatments such as targeted therapies and immunotherapies, highlight the need for more systematic and harmonized studies, possibly taking into account the complex and multifactorial etiology of CRCI. This may provide valuable insights into CRCI’s underlying mechanisms and potential new ways to treat it.
Proteolysis in plant immunity
Authors: Liu Yanan , Jackson Edan , Liu Xueru , Huang Xingchuan , van der Hoorn Renier A L , Zhang Yuelin , Li Xin 
Published: May 2024

Abstract
Compared with transcription and translation, protein degradation machineries can act faster and be targeted to different subcellular compartments, enabling immediate regulation of signaling events. It is therefore not surprising that proteolysis has been used extensively to control homeostasis of key regulators in different biological processes and pathways. Over the past decades, numerous studies have shown that proteolysis, where proteins are broken down to peptides or amino acids through ubiquitin-mediated degradation systems and proteases, is a key regulatory mechanism to control plant immunity output. Here, we briefly summarize the roles various proteases play during defence activation, focusing on recent findings. We also update the latest progress of ubiquitin-mediated degradation systems in modulating immunity by targeting plant membrane-localized pattern recognition receptors, intracellular nucleotide-binding domain leucine-rich repeat receptors, and downstream signaling components. Additionally, we highlight recent studies showcasing the importance of proteolysis in maintaining broad-spectrum resistance without obvious yield reduction, opening new directions for engineering elite crops that are resistant to a wide range of pathogens with high yield.
A prion-like domain is required for phase separation and chloroplast RNA processing during cold acclimation in Arabidopsis
Authors: Legen Julia , Lenzen Benjamin , Kachariya Nitin , Feltgen Stephanie , Gao Yang , Mergenthal Simon , Weber Willi , Klotzsch Enrico , Zoschke Reimo , Sattler Michael , Schmitz-Linneweber Christian 
Published: May 2024

Abstract
Arabidopsis (Arabidopsis thaliana) plants can produce photosynthetic tissue with active chloroplasts at temperatures as low as 4°C, and this process depends on the presence of the nuclear-encoded, chloroplast-localized RNA-binding protein CP29A. In this study, we demonstrate that CP29A undergoes phase separation in vitro and in vivo in a temperature-dependent manner, which is mediated by a prion-like domain (PLD) located between the two RNA recognition motif domains of CP29A. The resulting droplets display liquid-like properties and are found near chloroplast nucleoids. The PLD is required to support chloroplast RNA splicing and translation in cold-treated tissue. Together, our findings suggest that plant chloroplast gene expression is compartmentalized by inducible condensation of CP29A at low temperatures, a mechanism that could play a crucial role in plant cold resistance.
A Self-Regulated Stochastic Acceleration Model of Pulsar Wind Nebulae
Authors: Tanaka Shuta J , Ishizaki Wataru 
Published: May 2024

Abstract
Pulsar wind nebulae (PWNe) are clouds of magnetized relativistic electron/positron plasma supplied from the central pulsar. However, the number of radio-emitting particles inside a PWN is larger than the expectation from the study of pulsar magnetospheres and their origin is still unclear. A stochastic acceleration of externally injected particles by a turbulence inside the PWN is proposed by our previous studies. In this paper, the previous stochastic acceleration model of the PWN broadband spectra is improved by taking into account the time evolution of the turbulent energy and then the total energy balance inside a PWN is maintained. The turbulent energy supplied from the central pulsar is wasted by the backreaction from the stochastic particle acceleration and the adiabatic cooling according to the PWN expansion. The model is applied to the Crab Nebula and reproduces the current broadband emission spectrum, especially the flat radio spectrum, although the time evolution of the turbulent energy (diffusion coefficient) is a bit complicated compared with our previous studies, where we assumed an exponential behavior of the diffusion coefficient.
Glycine/alginate-based piezoelectric film consisting of a single, monolithic β-glycine spherulite towards flexible and biodegradable force sensor
Authors: Lin Qiaoxia , Zhang Yonggang , Chen Luhua , Zhang Haoyue , An Chuanfeng , Li Chengze , Wang Qifan , Song Jinhui , He Wei , Wang Huanan 
Published: May 2024

Abstract
Development of piezoelectric biomaterials with high piezoelectric performance, while possessing excellent flexibility, biocompatibility, and biodegradability still remains a great challenge. Herein, a flexible, biocompatible and biodegradable piezoelectric β-glycine–alginate–glycerol (Gly-Alg-Glycerol) film with excellent in vitro and in vivo sensing performance was developed. Remarkably, a single, monolithic β-glycine spherulite, instead of more commonly observed multiple spherulites, was formed in alginate matrix, thereby resulting in outstanding piezoelectric property, including high piezoelectric constant (7.2 pC/N) and high piezoelectric sensitivity (1.97 mV/kPa). The Gly-Alg-Glycerol film exhibited superior flexibility, enabling complex shape-shifting, e.g. origami pigeon, 40% tensile strain, and repeated bending and folding deformation without fracture. In vitro, the flexible Gly-Alg-Glycerol film sensor could detect subtle pulse signal, sound wave and recognize shear stress applied from different directions. In addition, we have demonstrated that the Gly-Alg-Glycerol film sensor sealed by polylactic acid and beeswax could serve as an in vivo sensor to monitor physiological pressure signals such as heartbeat, respiration and muscle movement. Finally, the Gly-Alg-Glycerol film possessed good biocompatibility, supporting the attachment and proliferation of rat mesenchymal stromal cells, and biodegradability, thereby showing great potential as biodegradable piezoelectric biomaterials for biomedical sensing applications.
The impact of acute violent videogame exposure on neurocognitive markers of empathic concern
Authors: Ritchie Mary B , Compton Shannon A H , Oliver Lindsay D , Finger Elizabeth , Neufeld Richard W J , Mitchell Derek G V 
Published: May 2024

Abstract
Research examining the purported association between violent gaming and aggression remains controversial due to concerns related to methodology, unclear neurocognitive mechanisms, and the failure to adequately consider the role of individual differences in susceptibility. To help address these concerns, we used fMRI and an emotional empathy task to examine whether acute and cumulative violent gaming exposure were associated with abnormalities in emotional empathy as a function of trait-empathy. Emotional empathy was targeted given its involvement in regulating not only aggression, but also other important social functions such as compassion and prosocial behaviour. We hypothesized that violent gaming exposure increases the risk of aberrant social behaviour by altering the aversive value of distress cues. Contrary to expectations, neither behavioural ratings nor empathy-related brain activity varied as a function of violent gaming exposure. Notably, however, activation patterns in somatosensory and motor cortices reflected an interaction between violent gaming exposure and trait empathy. Thus, our results are inconsistent with a straightforward relationship between violent gaming exposure and reduced empathy. Furthermore, they highlight the importance of considering both individual differences in susceptibility and other aspects of cognition related to social functioning to best inform public concern regarding safe gaming practices.
Multi-omics explores the potential regulatory role of acetylation modification in flavonoid biosynthesis of Ginkgo biloba
Authors: Liu Xiaomeng , Ye Jiabao , Zhang Xiaoxi , Yang Ke , Zheng Jiarui , Cheng Shuiyuan , Zhang Weiwei , Xu Feng 
Published: May 2024

Abstract
Flavonoids are crucial medicinal active ingredients in Ginkgo biloba L. However, the effect of protein post-translational modifications on flavonoid biosynthesis remains poorly explored. Lysine acetylation, a reversible post-translational modification, plays a crucial role in metabolic regulation. This study aims to investigate the potential role of acetylation in G. biloba flavonoid biosynthesis. Through comprehensive analysis of transcriptomes, metabolomes, proteomes and acetylated proteins in different tissues, a total of 11,788 lysine acetylation sites were identified on 4324 acetylated proteins, including 89 acetylation sites on 23 proteins. Additionally, 128 types of differentially accumulated flavonoids were identified among tissues, and a dataset of differentially expressed genes related to the flavonoid biosynthesis pathway was constructed. Twelve (CHI, C3H1, ANR, DFR, CCoAOMT1, F3H1, F3H2, CCoAOMT2, C3H2, HCT, F3′5′H and FG2) acetylated proteins that might be involved in flavonoid biosynthesis were identified. Specifically, we found that the modification levels of CCoAOMT1 and F3′5′H sites correlated with the catalytic production of homoeriodictyol and dihydromyricetin, respectively. Inhibitors of lysine deacetylase (trichostatin A) impacted total flavonoid content in different tissues and increased flavonoid levels in G. biloba roots. Treatment with trichostatin A revealed that expression levels of GbF3′5′H and GbCCoAOMT1 in stems and leaves aligned with total flavonoid content variations, while in roots, expression levels of GbC3H2 and GbFG2 corresponded to total flavonoid content changes. Collectively, these findings reveal for the first time the important role of acetylation in flavonoid biosynthesis.
Long-Term Risk of Type 2 Diabetes After Preterm Delivery or Hypertensive Disorders of Pregnancy
Authors: Crump Casey , Sundquist Jan , Sundquist Kristina 
Published: May 2024

OBJECTIVE:
To examine long-term diabetes risk after preterm delivery or hypertensive disorders of pregnancy in a large population-based cohort.

METHODS:
This retrospective cohort study included all women with a singleton delivery in Sweden during 1973–2015 and no preexisting diabetes mellitus. Participants were followed up for development of type 2 diabetes identified from nationwide outpatient and inpatient diagnoses through 2018. Cox regression was used to compute hazard ratios (HRs) for the association between preterm delivery or hypertensive disorders of pregnancy and type 2 diabetes with adjustment for gestational diabetes and other maternal factors. Co-sibling analyses assessed for confounding by shared familial (genetic or environmental) factors.

RESULTS:
Overall, 2,184,417 women were included. Within 10 years after delivery, adjusted HRs for type 2 diabetes associated with specific pregnancy outcomes were as follows: any preterm delivery (before 37 weeks of gestation), 1.96 (95% CI, 1.83–2.09); extremely preterm delivery (22–27 weeks), 2.53 (95% CI, 2.03–3.16); and hypertensive disorders of pregnancy, 1.52 (95% CI, 1.43–1.63). All HRs remained significantly elevated (1.1–1.7-fold) 30–46 years after delivery. These findings were largely unexplained by shared familial factors.

CONCLUSION:
In this large national cohort, preterm delivery and hypertensive disorders of pregnancy were associated with increased risk for type 2 diabetes up to 46 years later. Women with these pregnancy complications are candidates for early preventive actions and long-term monitoring for type 2 diabetes.