bluuebunny/crossref_metadata_2025_split huggingface dataset:
Genotypic abundance of carotenoids and polyphenolics in the hull of field pea (Pisum sativum L.)
Authors: Marles MA Susan , Warkentin Thomas D , Bett Kirstin E 
Published: July 2012

AbstractBACKGROUND: Consumption of pulse crops, including field pea, is considered effective for a healthy diet. Hulls (seed coats) play an important role for protection of the cotyledon and embryo, but also as mediating positive effects on health outcomes. The biochemical attributes of field pea hulls were thus assessed to determine the occurrence of specific phytochemicals and their genotypic variability.RESULTS: Sequestered bioproducts in mature hulls predominantly consisted of trans‐lutein and chlorophylls a and b. Trace amounts of other carotenoid and pheophytin metabolites were identified. In developing hulls, violaxanthin, neoxanthin, lutein, zeaxanthin, chlorophylls a and b and β‐carotene were detected. Genotypic differences in the accumulation of lutein and chlorophylls a and b were observed over years and locations. Polyphenolics and hydroxybenzoic acids were detected in the ‘dun’ and ‘maple’ field pea types—the only genotypes to have pigmented hulls. Unextractable patches of condensed tannin influenced the visual uniformity of the maple and dun genotypes, CDC Rocket and CDC Dundurn.CONCLUSIONS: Within the yellow and green market classes, carotenoid and chlorophyll accumulation was consistent. Green cotyledon varieties sequestered higher concentrations of lutein than the yellow cotyledon varieties. Maple and dun types were more variable, reflective of different selection criteria. The occurrence of flavonoid‐related compounds was correlated only with pigmented seed coat genotypes. The dietary potential of the chlorophylls and carotenoids that accumulated in the hulls split from the green and yellow field pea types is discussed as a value‐added prospect in food supplements. © 2012 Society of Chemical Industry
Development and optimisation by means of sensory analysis of new beverages based on different fruit juices and sherry wine vinegar
Authors: Cejudo‐Bastante María Jesús , Rodríguez Dodero M. Carmen , Durán Guerrero Enrique , Castro Mejías Remedios , Natera Marín Ramón , García Barroso Carmelo 
Published: July 2012

AbstractBACKGROUND: Despite the long history of sherry wine vinegar, new alternatives of consumption are being developed, with the aim of diversifying its market. Several new acetic‐based fruit juices have been developed by optimising the amount of sherry wine vinegar added to different fruit juices: apple, peach, orange and pineapple. Once the concentrations of wine vinegar were optimised by an expert panel, the aforementioned new acetic fruit juices were tasted by 86 consumers. Three different aspects were taken into account: habits of consumption of vinegar and fruit juices, gender and age.RESULTS: Based on the sensory analysis, 50 g kg−1 of wine vinegar was the optimal and preferred amount of wine vinegar added to the apple, orange and peach juices, whereas 10 g kg−1 was the favourite for the pineapple fruit. Based on the olfactory and gustatory impression, and ‘purchase intent’, the acetic beverages made from peach and pineapple juices were the most appreciated, followed by apple juice, while those obtained from orange juice were the least preferred by consumers.CONCLUSION: New opportunities for diversification of the oenological market could be possible as a result of the development of this type of new product which can be easily developed by any vinegar or fruit juice maker company. © 2012 Society of Chemical Industry
Adrenal insufficiency
Authors: Li‐Ng Melissa , Kennedy Laurence 
Published: July 2012

AbstractAdrenocortical insufficiency may arise through primary failure of the adrenal glands or due to lack of ACTH stimulation as a result of pituitary or hypothalamic dysfunction. Prolonged administration of exogenous steroids will suppress the hypothalamic–pituitary‐adrenal axis, and hence cortisol secretion. We review briefly the causes, investigation, and treatment of adrenal insufficiency, and highlight aspects of particular relevance to patients with adrenal tumors. J. Surg. Oncol. 2012; 106:595–599. © 2012 Wiley Periodicals, Inc.
Modest advances in survival for patients with colorectal‐associated peritoneal carcinomatosis in the era of modern chemotherapy
Authors: Zani Sabino , Papalezova Katia , Stinnett Sandra , Tyler Douglas , Hsu David , Blazer Dan G. 
Published: July 2012

AbstractBackgroundThe treatment of metastatic colorectal cancer (CRC) has evolved rapidly over the last decade, with combination chemotherapy and targeted biologic agents leading to significant improvements in survival. Despite these advances, little is known about their effectiveness in CRC‐associated peritoneal carcinomatosis. The purpose of this study was to evaluate outcomes in patients with CRC‐associated PC treated in the era of modern chemotherapy.MethodsWe retrospectively reviewed an institutional tumor database from 1996 to 2008. Survival data were evaluated for patients treated with PC before and after 2003. No patients before 2003 were treated with combination chemotherapy or biologic therapy. The modern chemotherapy group consisted of patients treated after 2003. Survival curves were estimated.ResultsOverall, 173 patients were identified. Median follow‐up was 8.6 months. Median survival in the historic group (n = 91) was 8.9 months and 16.3 months in the modern chemotherapy group (n = 82) (P < 0.004). Age was the only significant covariate. The survival difference between the modern chemotherapy cohort and control cohort persisted after adjustment for age. In a subset of patients in the modern chemotherapy era group, for which treatment regimen could be definitively identified, survival was even greater—23.8 months.ConclusionsPatients with CRC‐associated PC treated with modern combination chemotherapy and biologic therapy have a significantly longer median survival compared to our historical cohort. Despite these improvements, outcomes still remain poor. Therapeutic adjuncts such as surgical cytoreduction and hyperthermic intraperitoneal chemotherapy (HIPEC) in appropriately selected patients remain promising options to improve outcomes for patients with peritoneal‐based disease. J. Surg. Oncol. 2013;107:307–311. © 2012 Wiley Periodicals, Inc.
Headspace solid‐phase microextraction combined with mass spectrometry as a powerful analytical tool for profiling the terpenoid metabolomic pattern of hop‐essential oil derived from Saaz variety
Authors: Gonçalves João , Figueira José , Rodrigues Fátima , Câmara José S. 
Published: July 2012

Hop (Humulus lupulus L., Cannabaceae family) is prized for its essential oil contents, used in beer production and, more recently, in biological and pharmacological applications. In this work, a method involving headspace solid‐phase microextraction and gas chromatography–mass spectrometry was developed and optimized to establish the terpenoid (monoterpenes and sesquiterpenes) metabolomic pattern of hop‐essential oil derived from Saaz variety as a mean to explore this matrix as a powerful biological source for newer, more selective, biodegradable and naturally produced antimicrobial and antioxidant compounds.Different parameters affecting terpenoid metabolites extraction by headspace solid‐phase microextraction were considered and optimized: type of fiber coatings, extraction temperature, extraction time, ionic strength, and sample agitation. In the optimized method, analytes were extracted for 30 min at 40°C in the sample headspace with a 50/30 μm divinylbenzene/carboxen/polydimethylsiloxane coating fiber. The methodology allowed the identification of a total of 27 terpenoid metabolites, representing 92.5% of the total Saaz hop‐essential oil volatile terpenoid composition. The headspace composition was dominated by monoterpenes (56.1%, 13 compounds), sesquiterpenes (34.9%, 10), oxygenated monoterpenes (1.41%, 3), and hemiterpenes (0.04%, 1) some of which can probably contribute to the hop of Saaz variety aroma. Mass spectrometry analysis revealed that the main metabolites are the monoterpene β‐myrcene (53.0 ± 1.1% of the total volatile fraction), and the cyclic sesquiterpenes, α‐humulene (16.6 ± 0.8%), and β‐caryophyllene (14.7 ± 0.4%), which together represent about 80% of the total volatile fraction from the hop‐essential oil. These findings suggest that this matrix can be explored as a powerful biosource of terpenoid metabolites.
Dual‐band coplanar waveguide‐fed monopole antenna for 2.4/5.8 GHz radiofrequency identification applications
Authors: Ojaroudi Mohammad , Ojaroudi Nasser 
Published: July 2012

AbstractIn this article, a novel design of dual‐band printed monopole antenna fed by a coplanar waveguide for radiofrequency identification (RFID) applications is presented. By cutting two vertical rectangular slits in the radiating patch, a new resonance at lower frequencies (2.4 GHz) can be achieved, also by embedding a rotated C‐shaped slot, the antenna achieves good dual‐band operation. The measured impedance bandwidth for –10 dB return loss is from 2.05 to 2.89 GHz (34%) and 5.10 to 6.09 GHz (15.0%), covering the 2.4/5.8 GHz RFID operating bands. Simulated and experimental results obtained for this antenna show that the proposed single band‐notch square monopole antenna has a good antenna gains and radiation behavior within the 2.4/5.8 GHz frequencies. The designed antenna has a small size of 12 × 18 mm2. © 2012 Wiley Periodicals, Inc. Microwave Opt Technol Lett 54:2426–2429, 2012; View this article online at wileyonlinelibrary.com. DOI 10.1002/mop.27064
A diaphragm based low‐cost fiber optic pressure sensor
Authors: Vengal Rao P. , Srimannarayana K. , Sai Shankar M. , Kishore P. , Sengupta D. , Saidi Reddy P. 
Published: July 2012

AbstractThis article presents a low cost fiber optic pressure sensor using metal diaphragm.The sensor works on the principle of fiber optic proximity sensor. As the pressure varies, the deflection of the diaphragm varies and it modulates the intensity of light reflecting from the diaphragm. The performance of the sensor is studied for different diameters and thicknesses of the diaphragm. © 2012 Wiley Periodicals, Inc. Microwave Opt Technol Lett 54:2229–2231, 2012; View this article online at wileyonlinelibrary.com. DOI 10.1002/mop.27093
Proton‐conducting blend membranes of crosslinked poly(vinyl alcohol)–sulfosuccinic acid ester and poly(1‐vinyl‐1,2,4‐triazole) for high temperature fuel cells
Authors: Boroglu Mehtap Safak , Celik Sevim Unugur , Bozkurt Ayhan , Boz Ismail 
Published: July 2012

AbstractNew type of composite membranes were synthesized by crosslinking of poly(vinyl alcohol) (PVA) with sulfosuccinic acid (SSA) and intercalating poly(1‐vinyl‐1,2,4‐triazole) (PVTri) into the resulting matrix. The complexed structure of the membranes was confirmed by Fourier transform infrared (FTIR) spectroscopy. The resulting hybrid membranes were transparent, flexible, and showed good thermal stability up to ∼200°C. The proton conductivities of the membranes were investigated as a function of PVTri and SSA and operating temperature. The water/methanol uptake was measured and the results showed that solvent absorption of the materials increased with increasing PVTri content in the matrix. The proton conductivity of the membranes continuously increased with increasing SO3H content, PVTri content, and the temperature. In the anhydrous state, the maximum proton conductivity is 7.7 × 10−5 S/cm for PVA–SSA–PVTri‐1 and for PVA–SSA–PVTri‐3 is 1.6 × 10−5 S/cm at 150°C. After humidification (RH = 100%), PVA–SSA–PVTri‐4 showed a maximum proton conductivity of 0.0028 S/cm at 60°C. POLYM. ENG. SCI., 2013. © 2012 Society of Plastics Engineers
Surface properties and blood compatibility of some aliphatic/aromatic polyimide blends
Authors: Nica Simona‐Luminita , Hulubei Camelia , Stoica Iuliana , Emil Ioanid Ghiocel , Ioan Silvia 
Published: July 2012

AbstractTwo binary polyimide (PI) blends having a common monomer, diamine and dianhydride, were prepared. The first system was composed of PIs obtained from an alicyclic and flexible dianhydride, namely 5‐(2,5‐dioxotetrahydrofurfuryl)‐3‐methyl‐3‐cyclohexene‐1,2‐dicarboxylic acid anhydride (DOCDA) and two aromatic diamines, 4,4′‐oxydianiline (ODA) and p‐phenylenediamine (PPD), respectively. In the second system, ODA was combined with DOCDA and (hexafluoroisopropyldiene)diphtalic dianhydride (6FDA). Incorporation of aliphatic and asymmetric DOCDA moieties, hexafluoropropyldiene groups and ether linkages in the molecular structure of PI blends, poly(DOCDA/PPD)/poly(DOCDA‐ODA) and poly(6FDA‐ODA)/poly(DOCDA‐ODA) influenced the surface tension parameters, surface and interfacial free energy, and the work of spreading of water, maintaining the surface hydrophobic characteristics of both systems. In addition, it has been found out that surface hydrophobicity and surface roughness are properties that can be correlated with the red blood cells and platelets compatibility. POLYM. ENG. SCI., 2013. © 2012 Society of Plastics Engineers
Study on the preparation and properties of novel block copolymeric materials based on structurally modified organometallic as well as organic polyamides and polydimethylsiloxane
Authors: Khan Muhammad Saif Ullah , Akhter Zareen , Naz Touseef , Bhatti Arshad Saleem , Siddiqi Humaira M , Siddiq Mohammad , Khan Abbas 
Published: July 2012

AbstractSome novel ferrocene‐containing polyamide‐based block copolymer materials with telechelic polydimethylsiloxane oligomer and their organic analogues were prepared by solution‐phase polycondensation of ferrocene‐based organometallic and terephthaloyl‐ as well as isophthaloyl‐based organic acyl chlorides with a series of semi‐aromatic diamines having ether linkages together with variable aliphatic character. The corresponding polyamides of the synthesized materials, without polydimethylsiloxane segment, were also prepared for comparison of physicochemical properties. None of the synthesized organometallic and organic block copolymers along with their respective polyamides melted below 300 °C and their structural features were confirmed by their physical properties and spectroscopic studies. The weight‐average molecular weights and molecular parameters of all these materials were determined by the static laser light scattering technique. The materials were soluble in sulfuric acid and partially soluble in common organic solvents, and yet became readily soluble upon N‐trifluoroacetylation. The synthesized materials were further characterized by their water absorption characteristics, X‐ray diffraction studies and surface morphology (SEM and AFM) and thermal (DSC and TG) analyses, and their structure–property relationships were elucidated from these studies. The energies of pyrolysis for these materials were calculated by the Horowitz and Metzger method. © 2012 Society of Chemical Industry
Synthesis and properties of new aromatic polyimides containing redox‐active anthraquinone moieties
Authors: Hsiao Sheng‐Huei , Kung Yi‐Ruei 
Published: July 2012

AbstractA novel anthraquinone‐containing bis(ether amine) monomer, 2,6‐bis(4‐aminophenoxy)anthraquinone, was synthesized from readily available reagents. A series of novel aromatic polyimides were prepared from the newly synthesized diamine monomer with various aromatic tetracarboxylic dianhydrides. The intermediate poly(amic acid)s had inherent viscosities of 0.67–1.12 dL g−1, and those derived from less stiff dianhydrides could be solution‐cast and thermally cyclodehydrated into flexible and tough polyimide films. The polyimides exhibited glass transition temperatures between 270 and 297 °C, and they were fairly stable up to a temperature of 500 °C in air or nitrogen. The electrochemical and electrochromic properties of one of the polyimides were investigated. The polymer could undergo two reversible steps of electrochemical reduction, with a color change from a colorless neutral state to pink and rose‐red reduced states. © 2012 Society of Chemical Industry
Constitutionally isomeric alicyclic polyimides: Origin of siteselectivity in the reaction of unsymmetrical dianhydride and structure‐derived difference in physical properties
Authors: Choi Jiyoung , Shirai Kazuaki , Takayama Toshio , Akagawa Kengo , Kudo Kazuaki 
Published: July 2012

AbstractTwo constitutionally isomeric alicyclic polyimides (PIs), head‐to‐head (HH) and random types, were successfully synthesized on the basis of a siteselective ring opening reaction of an unsymmetric spiroalicyclic dianhydride, rel‐[1R,5S,6R]‐3‐oxabicyclo[3,2,1]octane‐2,4‐dione‐6‐spiro‐3′‐(tetrahydrofuran‐2′,5′‐dione), with using several kinds of diamines only by changing reaction procedures. A model reaction study revealed that the origin of the siteselectivity in the reaction of the dianhydride was due to both the enhanced reactivity of six‐membered anhydride embedded in bicyclo[3.2.1] system and the reduced reactivity of five‐membered anhydride in the spiro[4.5] system. The HH‐PIs showed higher glass transition temperature and higher dielectric constant than those of random PIs. Specific gravity of the PI films showed that the differences in physical properties stem from different packing density of the two constitutionally isomeric PIs. This is the first example for constitutionally isomeric both amorphous polycondensates with different physical properties. © 2012 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem, 2012
Role of spontaneous breathing trial in predicting successful extubation in premature infants
Authors: Chawla Sanjay , Natarajan Girija , Gelmini Matthew , Kazzi S. Nadya J. 
Published: July 2012

AbstractBackgroundThe ability of clinicians to predict successful extubation in mechanically ventilated premature neonates is limited. Identifying objective criteria for predicting successful extubation may reduce the incidence of failed extubation and the duration of mechanical ventilation.ObjectiveTo evaluate the validity of objective measures of lung function and spontaneous breathing trial (SBT) in predicting successful extubation among premature neonates with attempted extubations within the first 3 weeks of life.MethodsRespiratory compliance (Crs) along with SBT was performed prior to elective extubations within 3 weeks of age in premature infants ≤32 weeks. Extubation was considered successful if patients remained extubated for >72 hr. Ventilator settings including mean airway pressure (MAP), set rate, and fraction of inspired oxygen (FiO2) 24 hr after re‐intubation were compared with pre‐extubation settings, in patients requiring re‐intubation.ResultsThirty‐nine of 49 infants (80%) were successfully extubated. Of 41 babies who passed SBT, only 5 infants failed extubation. SBT had 92% sensitivity, 50% specificity, 88% positive predictive, and 63% negative predictive value for successful extubation. Crs was comparable between infants who were successfully extubated and those who were not.ConclusionsA SBT prior to extubation may be a practical objective adjunct in predicting successful extubation in ventilated premature infants. Pediatr Pulmonol. 2013; 48:443–448. © 2012 Wiley Periodicals, Inc.
Synthesis and evaluation of a new series of tri‐, di‐, and mono‐N‐alkylcarbamylphloroglucinols as conformationally constrained inhibitors of cholesterol esterase
Authors: Lin Ming‐Cheng , Lin Gin‐Zen , Hwang Ching‐In , Jian Shuo‐Yung , Lin James , Shen Yu‐Fong , Lin Gialih 
Published: July 2012

Abstract1,3,5‐Tri‐N‐alkylcarbamylphloroglucinols (1–4) are synthesized as conformationally constrained analogs of triacylglycerols (TGs) to probe Jenck's proximity effect in the cholesterol esterase inhibition. For the cholesterol esterase inhibition, inhibitors 1–4 are 220–760‐fold more potent than 1,2,3‐tri‐N‐alkylcarbamylglycerols (13–15) that are substrate analogs of TG. Comparison of tridentate inhibitors 1–4, bidentate inhibitors 3,5‐di‐N‐n‐alkylcarbamyloxyphenols (5–8) and monodentate inhibitors 5‐N‐n‐alkylcarbamyloxyresorcinols (9–12) indicates that inhibitory potencies are as followed: tridentate inhibitor > bidentate inhibitor > monodentate inhibitor. The log ki and pKi values of tridentate inhibitors, bidentate inhibitors, and monodentate inhibitors are linearly correlated with the alkyl chain length indicating a common mechanism in each inhibition. Also, positive slopes of these correlations indicate that the longer chain inhibitors bind more tightly to the enzyme than the shorter ones. Molecular dockings of tridentate 1, bidentate 5, and monodentate 9 into the X‐ray crystal structure of cholesterol esterase suggest that one carbamyl group in the cis form of the inhibitor binds to the acyl chain‐binding site of the enzyme. The second carbamyl groups in the trans forms of inhibitors 1 and 5 bind to the second acyl chain‐binding site of the enzyme. The third carbamyl group in the trans form of inhibitor 1 binds to the third acyl chain‐binding site of the enzyme. Moreover, the configuration of the inhibitor in the enzyme‐inhibitor complex is the (1,3,5)‐(cis, trans, trans)‐tricarbamate form that mimics the (+gauche, −gauche)‐conformation of TG.
Characterization of the highly conserved VFMGD motif in a bacterial polyisoprenyl‐phosphate N‐acetylaminosugar‐1‐phosphate transferase
Authors: Furlong Sarah E. , Valvano Miguel A. 
Published: July 2012

AbstractPolyisoprenyl‐phosphate N‐acetylaminosugar‐1‐phosphate transferases (PNPTs) constitute a family of eukaryotic and prokaryotic membrane proteins that catalyze the transfer of a sugar‐1‐phosphate to a phosphoisoprenyl lipid carrier. All PNPT members share a highly conserved 213‐Valine‐Phenylalanine‐Methionine‐Glycine‐Aspartic acid‐217 (VFMGD) motif. Previous studies using the MraY protein suggested that the aspartic acid residue in this motif, D267, is a nucleophile for a proposed double‐displacement mechanism involving the cleavage of the phosphoanhydride bond of the nucleoside. Here, we demonstrate that the corresponding residue in the E. coli WecA, D217, is not directly involved in catalysis, as its replacement by asparagine results in a more active enzyme. Kinetic data indicate that the D217N replacement leads to more than twofold increase in Vmax without significant change in the Km for the nucleoside sugar substrate. Furthermore, no differences in the binding of the reaction intermediate analog tunicamycin were found in D217N as well as in other replacement mutants at the same position. We also found that alanine substitutions in various residues of the VFMGD motif affect to various degrees the enzymatic activity of WecA in vivo and in vitro. Together, our data suggest that the highly conserved VFMGD motif defines a common region in PNPT proteins that contributes to the active site and is likely involved in the release of the reaction product.
Soft–Soft interactions in the protein–protein recognition process: The K+ channel‐charybdotoxin case
Authors: Aparicio Felipe , González‐Rivas Nelly , Ireta Joel , Rojo Arturo , Escobar Laura I. , Cedillo Andrés , Galván Marcelo 
Published: July 2012

AbstractMolecular recognition between peptide blockers and ionic channels is a complex process that involves many effects. To determine if the short‐range charge transfer effects play a significant role in this interaction, a chemical reactivity analysis of charybdotoxin (ChTX) and six of its mutants was carried out using global and local reactivity indices. The results show that global softness correlates with the affinity of ChTX, and its mutants to the channel indicating that soft–soft interactions play a role in the recognition process between ChTX and a potassium channel. The analysis of the local reactivity indicates that the toxin as a whole can be seen as a complex polydentate ligand with several places to coordinate with the external vestibule of the pore of the potassium channels. The successful treatment of point mutations supports the idea of using this tool in the study of chemical reactivity in proteins, in a similar way as substituent effects in organic chemistry. © 2012 Wiley Periodicals, Inc.