bluuebunny/crossref_metadata_2025_split huggingface dataset:
Fibroadenoma of the vulva with pseudoangiomatous stromal hyperplasia: A common neoplasm in uncommon site
Authors: Homsi Haya A. , Sharma Anurag , Przybycin Christopher , Piliang Melissa 
Published: May 2024

AbstractMammary‐type tissue in the vulva was first described in 1872 but has been rarely reported in the literature. This tissue was previously considered as ectopic breast tissue that occurs as a result of incomplete regression of the milk line. Similar to native breast tissue, ectopic mammary tissue is hormone‐sensitive and can develop benign changes, such as fibroadenoma, as well as malignant changes. A more recent theory suggests that these benign and malignant mammary‐type entities arise from mammary‐like anogenital glands, which constitute normal vulvar components. We report a case of a 41‐year‐old woman who presented with a chronic asymptomatic cyst on the left vulva that eventually became uncomfortable, especially on standing. The cyst was located on the labium minus, measuring 1.0 × 0.5 cm, with no identified erythema or other skin abnormalities. Excision of the lesion and subsequent microscopic examination showed a circumscribed mass with a nodular overgrowth of epithelial and stromal components, resembling a mammary fibroadenoma with pseudoangiomatous stromal hyperplasia. We bring to attention this rare diagnosis and the importance of considering it in the presence of a vulvar lesion. The malignant and recurrence potential of mammary‐type tissue necessitates excision with clear margins and close monitoring of these patients.
Short‐term number sense training recapitulates long‐term neurodevelopmental changes from childhood to adolescence
Authors: Park Yunji , Zhang Yuan , Chang Hyesang , Menon Vinod 
Published: May 2024

AbstractNumber sense is fundamental to the development of numerical problem‐solving skills. In early childhood, children establish associations between non‐symbolic (e.g., a set of dots) and symbolic (e.g., Arabic numerals) representations of quantity. The developmental estrangement theory proposes that the relationship between non‐symbolic and symbolic representations of quantity evolves with age, with increased dissociation across development. Consistent with this theory, recent research suggests that cross‐format neural representational similarity (NRS) between non‐symbolic and symbolic quantities is correlated with arithmetic fluency in children but not in adolescents. However, it is not known if short‐term training (STT) can induce similar changes as long‐term development. In this study, children aged 7–10 years underwent a theoretically motivated 4‐week number sense training. Using multivariate neural pattern analysis, we investigated whether short‐term learning could modify the relation between cross‐format NRS and arithmetic skills. Our results revealed a significant correlation between cross‐format NRS and arithmetic fluency in distributed brain regions, including the parietal and prefrontal cortices, prior to training. However, this association was no longer observed after training, and multivariate predictive models confirmed these findings. Our findings provide evidence that intensive STT during early childhood can promote behavioral improvements and neural plasticity that resemble and recapitulate long‐term neurodevelopmental changes that occur from childhood to adolescence. More generally, our study contributes to our understanding of the malleability of number sense and highlights the potential for targeted interventions to shape neurodevelopmental trajectories in early childhood.Research Highlights
We tested the hypothesis that short‐term number sense training induces the dissociation of symbolic numbers from non‐symbolic representations of quantity in children.
We leveraged a theoretically motivated intervention and multivariate pattern analysis to determine training‐induced neurocognitive changes in the relation between number sense and arithmetic problem‐solving skills.
Neural representational similarity between non‐symbolic and symbolic quantity representations was correlated with arithmetic skills before training but not after training.
Short‐term training recapitulates long‐term neurodevelopmental changes associated with numerical problem‐solving from childhood to adolescence.
Fludarabine, cyclophosphamide, and rituximab as first‐line treatment in patients with chronic lymphocytic leukemia: A long‐term analysis of the German CLL Study Group (GCLLSG) registry
Authors: Kutsch Nadine , Giza Adam , Robrecht Sandra , Stumpf Janina , Federhen Anno , Stoltefuß Andrea , Vehling‐Kaiser Ursula , Koenigsmann Michael , Tausch Eugen , Schneider Christof , Stilgenbauer Stephan , Illmer Thomas , Schlag Rudolf , Dörfel Steffen , Gaska Tobias , Kiehl Michael , Müller‐Hagen Sigrun , Moorahrend Enno , Linde Hartmut , Schlenska‐Lange Anke , von Tresckow Julia , Fischer Kirsten , Eichhorst Barbara , Hallek Michael , Fink Anna Maria 
Published: May 2024

AbstractLong‐term data of chronic lymphocytic leukemia (CLL) patients with favorable risk who were treated with fludarabine, cyclophosphamide, and rituximab (FCR) within clinical trials show good efficacy. We here report long‐term data collected within the GCLLSG registry. Altogether, 417 CLL patients who received first‐line treatment with FCR were analyzed, of which 293 (70.3%) were treated outside of clinical trials. The median observation time from first‐line was 95.8 (interquartile range 58.7–126.8) months. Focusing on data of 194 (46.5%) patients who received FCR first‐line treatment after 2013 (start of data collection within GCLLSG registry), responses were documented in 85% of the patients, non‐responses in 15%, and for 3.6% the assessment was missing. Median event‐free survival (EFS, time until disease progression, subsequent treatment, or death) was 60.2 months with a 5‐year EFS‐rate of 50.6%. Patients with higher‐risk disease, characterized by unmutated IGHV (N = 78), had a median EFS of 45.4 months with a 5‐year EFS rate of 36.3%, while the median EFS was 77.5 months with a 5‐year EFS rate of 60.3% in patients with mutated IGHV (N = 40). Median overall survival was not reached with a 5‐year survival rate of 92.7%. In summary, first‐line FCR was associated with long EFS, especially in patients exhibiting a mutated IGHV status.
Ceroid lipofuscinosis type 2 disease: Effective presymptomatic therapy—Oldest case of a presymptomatic enzyme therapy
Authors: Breuillard Delphine , Ouss Lisa , Le Normand Marie Thérèse , Denis Timothée de Saint , Barnerias Christine , Robert Matthieu P. , Eisermann Monika , Boddaert Nathalie , Caillaud Catherine , Bahi‐Buisson Nadia , Desguerre Isabelle , Aubart Mélodie 
Published: May 2024

AbstractNeuronal ceroid lipofuscinosis type 2 (CLN2) disease is a rare, lysosomal storage disorder that causes pediatric onset neurodegenerative disease. It is characterized by mutations in the TPP1 gene. Symptoms begin between 2 and 4 years of age with loss of previously acquired motor, cognitive, and language abilities. Cerliponase alfa, a recombinant human TPP1 enzyme, is the only approved therapy. We report the first presymptomatic cerliponase alfa intraventricular treatment in a familial case of CLN2 related to a classical TPP1 variant. Sister 1 presented with motor, cognitive, and language decline and progressive myoclonic epilepsy since the age of 3 years, evolved with severe diffuse encephalopathy, received no specific treatment, and died at 11 years. Sister 2 had a CLN2 presymptomatic diagnosis and has been treated with cerliponase since she was 12 months old. She is now 6 years 8 months and has no CLN2 symptom except one generalized seizure 1 year ago. No serious adverse event has occurred. Repeated Wechsler Preschool and Primary Scale of Intelligence, Fourth Edition standardized index scores are heterogeneous in the extremely low to low average ranges. Mean length of utterances, a global index of sentence complexity, showed a delay, but a gradual improvement. The reported case enhances the major contribution of presymptomatic diagnosis and significant middle‐term treatment benefit for patients with CLN2.
A seven‐step guide to spatial, agent‐based modelling of tumour evolution
Authors: Colyer Blair , Bak Maciej , Basanta David , Noble Robert 
Published: May 2024

AbstractSpatial agent‐based models are frequently used to investigate the evolution of solid tumours subject to localized cell–cell interactions and microenvironmental heterogeneity. As spatial genomic, transcriptomic and proteomic technologies gain traction, spatial computational models are predicted to become ever more necessary for making sense of complex clinical and experimental data sets, for predicting clinical outcomes, and for optimizing treatment strategies. Here we present a non‐technical step by step guide to developing such a model from first principles. Stressing the importance of tailoring the model structure to that of the biological system, we describe methods of increasing complexity, from the basic Eden growth model up to off‐lattice simulations with diffusible factors. We examine choices that unavoidably arise in model design, such as implementation, parameterization, visualization and reproducibility. Each topic is illustrated with examples drawn from recent research studies and state of the art modelling platforms. We emphasize the benefits of simpler models that aim to match the complexity of the phenomena of interest, rather than that of the entire biological system. Our guide is aimed at both aspiring modellers and other biologists and oncologists who wish to understand the assumptions and limitations of the models on which major cancer studies now so often depend.
Role of micro‐constituents on the fatigue deformation micro‐mechanisms of IN 713 C alloy
Authors: Rai Rajesh Kumar , Chandra Sharat , Sahoo Biraj Kumar , Paulose Neeta 
Published: May 2024

AbstractThe cast IN 713 C alloy is extensively used in the aerospace and automobile industries. Even with improved casting methods, the inhomogeneity in the microstructure is still inevitable and causes strain localizations during cyclic loading. So far, the effect of microstructural variables on the low cycle fatigue (LCF) deformation behavior of IN 713 C alloy has rarely been studied. In this study, IN 713 C alloy is LCF tested at 650°C and 750°C for strain amplitudes of 0.35% to 0.6%. The results showed that the deformation heterogeneity resulted from carbides, γ′ precipitates, and γ–γ′ eutectics distribution, governing the LCF failure micro‐mechanisms. The principle fatigue cracks were seen to be initiated from the precipitate‐free zone and oxidized‐surface carbides. It is corroborated that the higher GNDs were observed at carbide/matrix, eutectic/matrix, γ′/matrix interfaces, and in the interdendritic areas where voids and cracks formed. The higher GNDs at these sites facilitate crack initiation and propagation.
Preference of treatment characteristics among people with haemophilia or their caregivers, and physicians in the Japanese healthcare environment
Authors: Fujii Teruhisa , Ishimura Masataka , Takao Satomi , Deguchi Ayumi 
Published: May 2024

AbstractIntroductionStudies of treatment preferences in haemophilia have been conducted in many countries. This study is the first to examine treatment characteristic preferences among people with haemophilia (PWH) and their caregivers, and physicians in Japan.AimTo examine current treatment preferences of PWH and their caregivers, plus those of physicians at haemophilia treatment centres (HTCs) and non‐HTCs for different treatment characteristics in Japan.MethodsPhysicians listed on a survey panel were invited to participate in the survey and to refer PWH and caregivers to participate in the survey. Web‐based surveys were conducted to examine physician and PWH/caregiver background, prophylaxis background, prophylaxis goals, understanding of haemophilia treatment products, important information sources, preferences while choosing prophylaxis products, understanding of the patient's condition, and potential product switching. A discrete choice experiment exercise was included in the survey.ResultsA total of 107 physicians and 44 PWH/caregivers participated in the study. Key treatment goals of physicians included optimisation of haemophilia management. PWH/caregivers were focused on quality of life and reduced treatment burden. Consistent differences in haemophilia treatment strategies at HTCs and non‐HTCs were observed for prescribed treatments, preferences in choosing prophylaxis products, understanding of patients’ condition, and reasons for potential product switch.ConclusionOur study utilises real‐world survey data and presents preferences for haemophilia treatment characteristics among physicians, PWH and their caregivers in Japan, which could encourage improvements in individualised treatment and disease management. Alignment between treatment approaches at HTCs and non‐HTCs could facilitate improvements in the quality of care for PWH across Japan.
Assessing the perceived value of a user‐led educational intervention to support recovery in a Swedish psychiatric organization: A qualitative case study
Authors: Reinius Maria , Al‐Adili Lina , Riggare Sara , Rodriguez Inka Helispää , Stenfors Terese , Brommels Mats 
Published: May 2024

AbstractIntroductionMany people with mental health issues recover and re‐establish their identity and find hope and meaning in life, irrespective of symptom burden. Recovery can be supported through learning and education, aiming at strengthening self‐management and coping skills. Such education offered by peers with lived experience is rare and scarcely reported. The aim was to assess the perceived value of an educational intervention, called the Patient School (PS), organized within a psychiatry organization by employed patient peers with lived experience.MethodsA qualitative case study based on interviews with people with mental health issues (n = 8), peer‐organizers (n = 4) and healthcare professionals (n = 4), and documents such as schedules and educational materials were used. First, the interviews were transcribed and analyzed using inductive conventional content analysis. Second, the findings were synthesized into a programme theory, illustrated in a logic model.ResultsThe perceived value of the PS was related to the willingness of peer‐organizers to share their own experiences, a sense of belonging, sharing with like‐minded and new knowledge, practical skills, roles and attitudes acquired. These experiences were empowering, decreased stigma and reassured user participants that one's identity is not defined by mental health issues. This increased self‐confidence paves the way for increased self‐management and creates a potential for a more efficient use of healthcare services.ConclusionWe conclude that this PS, organized within a psychiatry organization by salaried peers, achieved the same positive results as those reported in the literature and showed the value of having peer‐organizers being part of the staff.Patient or Public ContributionThis research was performed in a partnership between academic researchers and persons with user experience of psychiatric services, engaged in the educational intervention in the focus of the study. The research plan was co‐designed, and the analysis of the data collected was performed in collaboration. The participation of the co‐researchers with user experience gave the project team access to the study site, provided the team with insights into to study context and contributed with an understanding promoting the interpretation of the findings.
Outcomes of sequential third‐line therapies in patients with refractory overactive bladder
Authors: Chow Po‐Ming , Trump Tyler , Goldman Howard B. 
Published: May 2024

IntroductionSacral neuromodulation (SNM) and onabotulinumtoxinA (BoNTA) injection are third‐line therapies for overactive bladder (OAB). Although the efficacy of each third‐line treatment has been well established in clinical trials, there is far less information about performing one third‐line therapy after the other. Our aim is thus to investigate the outcomes of post‐SNM BoNTA and post‐BoNTA SNM as “second” third‐line treatments.MethodsWe retrospectively reviewed all OAB patients who had both SNM and BoNTA between 2013 and 2022. The primary endpoint was the response rates (>50% improvements) of the second third‐line treatments. Secondary endpoints were the proportion of the patients who achieved total dry, the duration of treatments of patients who had significant responses, and risk factors that are associated with treatment response or duration of treatments.ResultsA total of 172 patients had two third‐line therapies. There were 104 patients who had post‐SNM BoNTA and 68 patients who had post‐BoNTA SNM. In the post‐SNM BoNTA group, 62.5% (65/104) had significant responses after BoNTA treatment. In the post‐BoNTA SNM group, 61.8% (44/68) had significant responses after SNM treatment. The proportions of patients who became dry were 21.2% and 23.5%, respectively. In the post‐SNM BoNTA group, spinal pathology is associated with a lower probability of a significant response (48.9% vs. 73.7%, p‐value = 0.0105).ConclusionsBoNTA or SNM remains a viable option for refractory OAB after patients fail from one another. Spinal pathology is associated with a poorer response of post‐SNM BoNTA.
Professional values gained in postgraduate nursing education from the perspectives of master's and doctorate graduates: A mixed‐methods study
Authors: Yalniz Nazik , Şenyuva Emine , Görügen Ümran 
Published: May 2024

AbstractAimTo determine the professional values of graduates of master's and doctoral programs in nursing and their views on the contribution of postgraduate education to their professional values.BackgroundIn postgraduate education, which is an important catalyst of professional identity development, a professional is expected to specialize in a field, get into more depth professionally, internalize professional values, and reflect and strengthen these values. To shed light on this expectation, more information is needed to assess the impact of postgraduate education on professional values.MethodsA convergent parallel mixed‐methods design was used. Data were collected for the quantitative part of the study for 385 graduates of postgraduate nursing education programs in Turkey who were selected using the snowball sampling method, while the maximum variation sampling method was used to collect data from 12 individuals for the qualitative part of the study. The Nurses Professional Values Scale (NPVS) and a Semi‐Structured Interview Form were used to collect data in October‐December 2022. The quantitative data obtained in the study were analyzed using the SPSS software, and the qualitative data were analyzed using the MAXQDA software.ResultsThe mean total NPVS score of the participants was 130.32 ± 21.34 (possible range: 31–155). Among all dimensions, the highest mean score of the participants was in the caring dimension, followed by professionalism and activism. There were significant differences in the NPVS total and subscale scores of the participants based on their views on the contributions of age, institution where they worked, marital status, position at work, and postgraduate education to the acquisition of professional values. In the qualitative dimension of the study, two main themes were identified. One of these themes was the theme of professional values in postgraduate nursing education that covered the categories of professional values gained through postgraduate education, professional values that a nurse who has completed postgraduate education should have, and professional values in postgraduate nursing education. The second theme was the theme named recommendations for providing nurses with professional values through postgraduate education. The integration of data from both components indicated that the qualitative interviews enriched the quantitative findings.ConclusionIt was concluded that postgraduate nursing education programs contribute greatly to the professional values of graduates and strengthen their professional values.Implications for nursing and health policyFor the future of nursing, increasing professional strengths and visibility is significantly associated with professional values. This situation requires nurses with strong professional values. Graduate education programs in nursing should be developed in this direction and focus on development of professional values.
Fabrication and properties of pink 3 mol% yttria‐stabilized zirconia ceramics with high toughness
Authors: Liu Qiang , Yang Yudie , Chen Haohong , Zhang Lixuan , Jing Yanqiu , Hu Chen , Chen Penghui , Li Tingsong , Ivanov Maxim , Hreniak Dariusz , Li Jiang 
Published: May 2024

AbstractTo broaden the applications of yttria‐stabilized zirconia (YSZ) in mobile phone back panels and high‐end decorative materials, the 3 mol% YSZ (3YSZ) ceramics doped with erbium oxide (Er2O3) as colorant were successfully sintered at 1250 and 1350°C in air. The influences of Er2O3‐doping concentration and sintering temperature on the phase, microstructure, color, and mechanical properties of the pink Er2O3‐3YSZ ceramics were investigated. As the Er2O3 concentration increased, the redness value a* gradually increased, while the yellowness value b* and the lightness value L* gradually decreased. The highest value a* and b* of Er2O3‐3YSZ ceramics reached absolute values of 15.2 and 4.5, respectively. The effect of Er2O3 concentration is also depicted in detail, which also affects the mechanical properties including hardness and fracture toughness of the ceramics. The maximum hardness and fracture toughness of Er2O3‐3YSZ ceramics reached 13.9 ± 0.3 GPa and 6.21 ± 0.20 MPa·m1/2, respectively. The hardness of the ceramics exceeds 12.5 GPa, which is the required market index for further practical application. This work provides a method for preparing 3YSZ ceramics with excellent mechanical properties and bright pink color, which has the potential to be used in the fields of advanced and superior electronics in particular.
Traversing the Great Lakes: Post‐glacial colonization by a widespread terrestrial salamander
Authors: Waldron Brian P. , Watts Emily F. , Kuchta Shawn R. 
Published: May 2024

AbstractAimsGlacial retreat at the end of the Pleistocene epoch opened vast expanses of emergent habitat in the northern hemisphere that were colonized by opportunistic taxa. However, species that undergo post‐glacial expansion may have originated from one or several glacial refugia. We inferred the post‐glacial expansion history of the Eastern Red‐backed Salamander (Plethodon cinereus), a fully terrestrial species with a vast distribution despite severe dispersal limitations. Previous studies indicated populations south of the glacial boundary at the eastern and western limits of the distribution were closely related, suggesting either multiple refugia or an extraordinary post‐glacial expansion event.LocationEastern North America.Taxon
Plethodon cinereus (Green, 1818), Caudata: Plethodontidae.MethodsWe collected ddRAD‐seq data from 106 individuals throughout the distribution of P. cinereus. We estimated phylogeographic structure, including finer‐scale structure among the post‐glacial populations. To test the origins and routes of colonization, we used ecological niche modelling, population trees and analyses of directional range expansion.ResultsAnalyses supported our hypothesis of a southeastern glacial refugium, with northward expansion along the Eastern Seaboard prior to westward invasion into the Great Lakes region, including southwestern expansion into unglaciated areas at the western end of the distribution. However, a distinct subgroup in the northwestern portion of the range raises the possibility of a second refugium near the ice‐free Driftless Area.Main ConclusionsBased on our results, we hypothesize a southeastern refugium from which most of today's northern populations undertook extensive post‐glacial colonization. Our results indicate a geographically non‐linear colonization history for P. cinereus.