bluuebunny/crossref_metadata_2025_split huggingface dataset:
ChemInform Abstract: Synthesis of 1,5‐Benzothiazepine Derivatives Bearing 2‐Phenoxy‐quinoline Moiety via 1,3‐Dipolar Cycloaddition Reaction.
Authors: Dong Zhi‐Qiang , Liu Fang‐Ming , Xu Feng , Yuan Zai‐Liang 
Published: February 2012

AbstractNitrile oxides and nitrile imines, generated in situ, undergo 1,3‐dipolar cycloaddition with the benzothiazepine derivative (I) to give cycloadducts containing oxadiazole or triazole moieties.
ChemInform Abstract: X‐Ray Structural Analysis and Theoretical Studies of New Phosphite‐Derived Ylides.
Authors: Rostamizadeh Mohsen , Maghsoodlou Malek Taher , Habibi‐Khorassani Sayyed Mostafa , Hazeri Nourallah , Charati Faramarz Rostami , Kazemian Mohammad Amin , Skelton Brian W. , Makha Mohamed 
Published: February 2012

AbstractThe reaction between electron‐deficient acetylenedicarboxylates (I), triethyl phosphite (II), and N‐H heterocycles (III) provides access to the stable phosphorus ylides (IV) in high yields.
ChemInform Abstract: Klysimplexins U—X, Eunicellin‐Based Diterpenoids from the Cultured Soft Coral Klyxum simplex.
Authors: Chen Bo‐Wei , Huang Chiung‐Yao , Wen Zhi‐Hong , Su Jui‐Hsin , Wang Wei‐Hsien , Sung Ping‐Jyun , Wu Yang‐Chang , Sheu Jyh‐Horng 
Published: February 2012

AbstractNone of the new eunicellin‐based diterpenoids (I)—(IV) is found to possess significant cytotoxicity and antiinflammatory activity.
ChemInform Abstract: Synthesis of the Precursor of K252a and Its Analogues.
Authors: Sun Xiuwei , Zhou Xuan , Ke Bowen , Song Hao , Wang Xiaolin , Yu Guofeng , Xu Tianshuai , Deng Xianglin 
Published: February 2012

AbstractA practical and efficient approach to diastereoisomeric furanoses (X) and (XI), key intermediates for the synthesis of the indole alkaloid K252a, is described.
ChemInform Abstract: N6‐Substituted Adenosines, Cytokinin and Antitumor Activities.
Authors: Kolyachkina Svetlana V. , Tararov Vitali I. , Alexeev Cyril S. , Krivosheev Dmitry M. , Romanov Georgy A. , Stepanova Evgenia V. , Solomko Eliso S. , Inshakov Andrey N. , Mikhailov Sergey N. 
Published: February 2012

AbstractThe synthesis of a series of N6‐substituted adenosines is described.
ChemInform Abstract: Usabamycins A—C: New Anthramycin‐Type Analogues from a Marine‐Derived Actinomycete.
Authors: Sato Seizo , Iwata Fumie , Yamada Shoichi , Kawahara Hiroyuki , Katayama Masashi 
Published: February 2012

AbstractThe title usabamycins (I), isolated from cultures of Streptomyces sp.
ChemInform Abstract: Toward the Total Synthesis of Bryostatin 11: Stereoselective Construction of the C13‐Exocyclic Enoate in the C1—C16 Fragment.
Authors: Nakagawa‐Goto Kyoko , Crimmins Michael T. 
Published: February 2012

AbstractA spiroketal template is utilized in the approach to the C1‐C16 fragment of bryostatin 11.
ChemInform Abstract: Identification of Mutaprodenafil in a Dietary Supplement and Its Subsequent Synthesis.
Authors: Demizu Yosuke , Wakana Daigo , Kamakura Hiroyuki , Kurihara Masaaki , Okuda Haruhiro , Goda Yukihiro 
Published: February 2012

AbstractThe new illegal sildenafil analogue named mutaprodenafil (I) is isolated from a dietary supplement for erectile dysfunction.
ChemInform Abstract: Synthesis and Photoluminescence Properties of the High‐Brightness Eu3+‐Doped M2Gd4(MoO4)7 (M: Li, Na) Red Phosphors.
Authors: Zhao Chengchun , Yin Xin , Huang Fuqiang , Hang Yin 
Published: February 2012

AbstractThe title phosphors are synthesized by solid state reaction of stoichiometric mixtures of M2CO3 (M: Li, Na), Gd2O3, Eu2O3, and Mo2O3 (air, 850 °C, 5 h).
Highly Sensitive Functionalized Conducting Copolypyrrole Film for DNA Sensing and Protein‐resistant
Authors: Zhang Zhihong , Li Guijuan , Yan Fufeng , Zhang Zhonghou , Fang Shaoming 
Published: February 2012

AbstractIn order to exploit the applications of polypyrrole (PPy) derivatives in biosensors and bioelectronics, the different immobilization mechanisms of biomolecules onto differently functionalized conducting PPy films are investigated. Pyrrole and pyrrole derivatives with carboxyl and amino groups were copolymerized with ω‐(N‐pyrrolyl)‐octylthiol self‐assembled on Au surface by the method of the chemical polymerization to form a layer of the copolymer film, i.e., poly[pyrrole‐co‐(N‐pyrrolyl)‐caproic acid] (poly(Py‐co‐PyCA)) and poly[pyrrole‐co‐(N‐pyrrolyl)‐hexylamine] (poly(Py‐co‐PyHA)), in which the carboxyl groups in poly(Py‐co‐PyCA) were activated to the ester groups. Based on the structure characteristics, the immobilization/hybridization of DNA molecules on PPy, poly(Py‐co‐PyCA) and poly(Py‐co‐PyHA) were surveyed by cyclic voltammograms measurements. For differently functionalized copolymers, the immobilization mechanisms of DNA are various. Besides the electrochemical properties of the composite electrodes of PPy and its copolymers being detected before and after bovine serum albumin (BSA) adsorption, the kinetic process of protein binding was determined by surface plasmon resonance of spectroscopy. Since few BSA molecules could anchor onto the PPy and its copolymers surfaces, it suggests this kind of conducting polymers can be applied as the protein‐resistant material.
Generation of Methyl Vinyl Ketone from Oxidation of Levulinic Acid Oxidized by Cupric Oxide Complex
Authors: Gong Yan , Lin Lu , Zhang Beixiao 
Published: February 2012

AbstractMethyl vinyl ketone (MVK) is a kind of high‐value chemical which has been widely used in many fields. In this paper, it is formed from oxidation of levulinic acid–a hydrolysis product of biomass. Copper oxide supported on cerium dioxide (CuO/CeO2) and alumina (CuO/Al2O3) were prepared and used for the oxidation of levulinic acid (LA). The oxidants were characterized by means of X‐ray diffraction (XRD), H2‐temperature programmed reduction (H2‐TPR) and atomic force microscope (AFM) techniques. CuO/CeO2 and CuO/Al2O3 show a different behavior with respect to pure CuO. The experiments revealed that CuO/CeO2 and CuO/Al2O3 can oxidize LA and get methyl vinyl ketone [yield of 15.5% detected by head space‐gas chromatograph‐mass spectrometer (HS‐GC‐MS)] under mild reactive conditions, while pure CuO oxidizes LA to produce butanone (MEK).
Electrochemical Sensor for Sensitive Determination of Ga(III) Ion Based on β‐Cyclodextrin Incorporated Multi‐walled Carbon Nanotubes and Imprinted Sol‐gel Composite Film
Authors: Hu Yufang , Zhang Zhaohui , Zhang Huabin , Luo Lijuan , Zhang Minglei , Yang Xiao , Yao Shouzhuo 
Published: February 2012

AbstractA novel sensor for detection of trace gallium ion [Ga(III)] was created by stepwise modification of a gold electrode with β‐cyclodextrin (β‐CD)/multi‐walled carbon nanotubes (MWCNTs) and an ion imprinted polymer (IIP). The sensor surface morphology was characterized by scanning electron microscopy. The electrochemical performance of the imprinted sensor was investigated by cyclic voltammetry, differential pulse voltammetry and chronoamperometry. The sensor displayed excellent selectivity towards the target Ga(III) ion. Meanwhile, the introduced MWCNTs displayed noticeable catalytic activity, and β‐CD demonstrated significant enrichment capacity. A linear calibration curve was obtained covering the concentration range from 5.0×10−8 to 1.0×10−4 mol·L−1, with a detection limit of 7.6×10−9 mol·L−1. The proposed sensor was successfully applied to detect Ga(III) in real urine samples.
Spectroscopic Studies on the Binding of Kaempferol‐3,7‐α‐L‐rhamnopyranoside to Bovine Serum Albumin
Authors: Yao Di , Yu Jing , Pan Yingming , Huang Fuping , Bian Hedong , Yu Qing , Liang Hong 
Published: February 2012

AbstractThe binding of kaempferol‐3,7‐α‐L‐rhamnopyranoside (KRR) with bovine serum albumin (BSA) was investigated by different spectroscopic methods under simulative physiological conditions. Analysis of ?uorescence quenching data of BSA by KRR at different temperatures using Stern‐Volmer methods revealed the formation of a ground state KRR‐BSA complex with moderate binding constant of the order 104 L·mol−1. The existence of some metal ions could weaken the binding of KRR on BSA. The changes in the van't Hoff enthalpy (ΔH0) and entropy (ΔS0) of the interaction were estimated to be −26.53 kJ·mol−1 and 3.33 J·mol−1·K−1 and both hydrophobic and electrostatic forces contributed to stabilizing the BSA‐KRR complex. According to the F?ster theory of non‐radiation energy transfer, the distance r between the donor (BSA) and the acceptor (KRR) was obtained (r=2.83 nm). Site marker competitive experiments showed that KRR could bind to Site I of BSA. In addition, synchronous fluorescence, UV‐Vis absorption and circular dichroism (CD) results indicated that the KRR binding could cause conformational changes of BSA.
Regulation of Glucose Oxidase Activity through Interaction with Fullerene Derivatives
Authors: Gao Yunyan , Wang Zhongli , Ou Zhize , Li Yi , Wang Xuesong , Yang Guoqiang 
Published: February 2012

AbstractThe 2‐(hydroxymethyl)pyridine modified C60 (PY‐C60) and methoxydiglycol modified C60 (MDG‐C60) are synthesized using Bingel‐Hirsch reaction and characterized by nuclear magnetic resonance (NMR) and mass spectra. PY‐C60 and MDG‐C60 can bind to glucose oxidase (GOx) and quench the fluorescence of tryptophan (Trp) residue in GOx through static mechanism. The conformation of GOx is disturbed after formation of complex with these fullerene derivatives. Kinetic analysis indicates that PY‐C60 and MDG‐C60 may affect the catalytic activity of GOx with a partial mixed‐type inhibition mechanism. In the plasma glucose concentration range (3.6–5.2 mmol·L−1), PY‐C60 may significantly accelerate the catalytic velocity of GOx, however, MDG‐C60 exerts almost no obvious change to the initial velocity of GOx, suggesting that elaborate design of molecular structure of fullerene derivative is very important for regulating the biological activity of fullerene‐enzyme complex.
Immobilization of Glucose Oxidase on Ordered Macroporous Silicas Functionalized with Amino Group
Authors: Wu Quanzhou , He Jianfeng , Zhang Jingjia , Ou Jiming 
Published: February 2012

AbstractA novel glucose oxidase immobilized on three‐dimensionally ordered macroporous (3DOM) material has been prepared by firstly preparation of hybrid 3DOM SiO2‐NH2 materials using colloidal crystal method, and following covalent immobilization of glucose oxidase on the pore walls of the 3DOM materials. The materials were characterized by SEM, FTIR, DSC and BET techniques. SEM observation shows that the macropores are highly ordered and are interconnected by small windows. FTIR measurement shows that there are amino and organic groups in the pore walls. The surface area of the 3DOM SiO2‐NH2 material is about 10.2 m2/g. The loaded amount of enzyme is increased with amino content in the materials. The immobilized enzyme has high activity, thermal stability and can be reused.
Synthesis and Photooxygenation of Furo[3,2‐c]coumarin Derivatives as Antibacterial and DNA Intercalating Agent
Authors: Al‐Sehemi Abdullah G. , El‐Gogary Sameh R. 
Published: February 2012

AbstractSyntheses of 2,3‐dimethyl‐4H‐furo[3,2‐c]coumarin and 3‐phenyl‐4H‐furo[3,2‐c]coumarin as angular furocoumarins were carried out through Williamson reaction of 4‐hydroxycoumarin with α‐haloketones followed by cyclization. Photooxygenation of the synthesized furocoumarin derivatives was performed and the photoproducts were isolated and characterized. The affinity of 2,3‐dimethyl‐4H‐furo[3,2‐c]coumarin towards DNA and the antibacterial activity were evaluated and compared with 8‐methoxypsoralen (8‐MOP).
Bromodimethylsulfonium Bromide Catalyzed Synthesis of Methyl 2‐Dexoy‐4,6‐O‐benzylidene Galactopyranoside from Galactal and the Rapid Route to 2,3‐ and 2,6‐Dideoxygalactopyranoses
Authors: Ding Ning , Chun Yuexing , Zhang Wei , Li Yingxia 
Published: February 2012

Abstract4,6‐O‐Benzylidenation of D‐galactal with PhCH(OCH3)2 catalyzed by bromodimethylsulfonium bromide leads to methyl 2‐dexoy‐4,6‐O‐benzylidene galactopyranoside efficiently, which serves as a key intermediate to the ready preparation of 2,3‐ and 2,6‐dideoxy galactopyranosides.
An Efficient and Green One‐pot Synthesis of 12‐Aryl‐8,9,10,12‐tetrahydrobenzo[a]xanthen‐11‐one Derivatives Promoted by Sulfamic Acid in [BMIM]BF4 Ionic Liquid
Authors: Zang Hongjun , Zhang Yong , Cheng Bowen , Zhang Weiwei , Xu Xianlin , Ren Yuanlin 
Published: February 2012

AbstractAn efficient and green procedure for the synthesis of novel 12‐aryl‐8,9,10,12‐tetrahydrobenzo[a]xanthen‐11‐one derivatives has been described through one‐pot condensation of 2‐naphthol, arylaldehyde and 5,5‐dimethyl‐cyclohexane‐1,3‐dione in the presence of sulfamic acid (NH2SO3H) in ionic liquid 1‐n‐butyl‐3‐methylimidazolium tetrafluoroborate ([BMIM]BF4). These reactions proceed with good yields under short reaction time. Furthermore, the green catalytic system can be recycled specific times with no decreases in yields and reaction rates.
Synthesis of β,β′‐Porphyrin Dimer Linked by Vinylene
Authors: Jiang Xuliang , Li Panli , Wang Yucheng , Shen Qi , Tao Jingchao , Shi Weimin 
Published: February 2012

AbstractSynthesis of a novel β,β′‐tetraalkylporphyrin dimer linked by vinylene was discribed, in which the dimer was readily prepared from a porphyrin‐derived Wittig reagent and a mono‐formylated porphyrin via Wittig reaction. No π‐conjugation between the two porphyrin rings was obserbed, and the dimer was in trans form.
Model checking and code generation for transaction processing software
Authors: Mentis Anakreon , Katsaros Panagiotis 
Published: February 2012

SUMMARYIn modern transaction processing software, the ACID properties (atomicity, consistency, isolation, durability) are often relaxed, in order to address requirements that arise in computing environments of today. Typical examples are the long‐running transactions in mobile computing, in service‐oriented architectures and B2B collaborative applications. These new transaction models are collectively known as advanced or extended transactions. Formal specification and reasoning for transaction properties have been limited to proof‐theoretic approaches, despite the recent progress in model checking. In this work, we present a model‐driven approach for generating a provably correct implementation of the transaction model of interest. The model is specified by state machines for the transaction participants, which are synchronized on a set of events. All possible execution paths of the synchronized state machines are checked for property violations. An implementation for the verified transaction model is then automatically generated. To demonstrate the approach, the specification of nested transactions is verified, because it is the basis for many advanced transaction models. Concurrency and Computation: Practice and Experience. Copyright © 2012 John Wiley & Sons, Ltd.
In Situ Reduction, Oxygen Etching, and Reduction Using Formic Acid: An Effective Strategy for Controllable Growth of Monodisperse Palladium Nanoparticles on Graphene
Authors: Yang Jun , Tian Chungui , Wang Lei , Tan Taixing , Yin Jie , Wang Bo , Fu Honggang 
Published: February 2012

AbstractGraphene‐supported, monodisperse palladium nanoparticles (Pd NPs) are fabricated successfully by an effective strategy combining in situ reduction, O2 etching, and reduction using formic acid without the use of surfactants. By utilizing the reductive ability of graphene prepared previously by an in situ, self‐generating template route, Pd2+ ions are first absorbed and partly in situ reduced to give Pd NPs on graphene (denoted as Pd/GN‐SR). The Pd NPs in Pd/GN‐SR exhibit poor monodispersion, large particle size, and low loading on graphene. Some unreduced Pd2+ ions still exist in the solution. Second, formic acid as the secondary reducing reagent is introduced into the same solution after the in situ reduction. Some Pd NPs on graphene are gradually etched to Pd2+ ions by oxygen dissolved in the solution, and therefore become smaller NPs. Meanwhile, with the formic acid further reduction, these Pd2+ ions and unreduced Pd2+ ions are together reduced as small‐sized Pd NPs on graphene (denoted as Pd/GN‐FA). X‐ray powder diffraction, X‐ray photoelectron spectroscopy, and transmission electron microscopy measurements show that the Pd NPs in Pd/GN‐FA have smaller particle size and higher monodispersion on graphene compared with that in Pd/GN‐SR. Furthermore, the electrooxidation of formic acid on the Pd/GN‐FA catalyst has been investigated by cyclic voltammetry. The Pd/GN‐FA catalyst exhibits enhanced electrocatalytic activity and stability towards formic acid oxidation owing to the small size, the high monodispersion of Pd NPs, and the stabilizing effect of graphene. The results presented herein indicate that the Pd/GN‐FA might be a promising anode electrocatalyst in direct formic acid fuel cells.
Assessing the Effects of Perceived Value and Satisfaction on Customer Loyalty: A ‘Green’ Perspective
Authors: Hur Won‐Moo , Kim Yeonshin , Park Kyungdo 
Published: February 2012

ABSTRACTTo promote an understanding of green consumption behavior, this paper investigates how consumer value relates to loyalty and price consciousness through consumer satisfaction. The proposed model of the variables underwent empirical validation through data collected from a cross‐sectional survey of 517 consumers in the USA who had bought and possessed a hybrid car – a representative green product. The results indicate that perceived social, emotional, and functional values have a significant positive effect on customer satisfaction with respect to green innovation. Further, customer satisfaction leads to customer loyalty, while lowering price consciousness. This study demonstrates the importance of consumer value and satisfaction in facilitating the diffusion of green innovation, with resulting implications for marketing strategy and public policy. Copyright © 2012 John Wiley & Sons, Ltd and ERP Environment.
Steric and Electronic Influences on the Structures of Peroxomanganese(III) Complexes Supported by Tetradentate Ligands
Authors: Geiger Robert A. , Wijeratne Gayan B. , Day Victor W. , Jackson Timothy A. 
Published: February 2012

AbstractWe report the generation and characterization of two peroxomanganese(III) complexes supported by the L7py24‐Cl and L7iso‐q2 ligands {L7py24‐Cl = 1,4‐bis[(4‐chloro‐2‐pyridyl)methyl]‐1,4‐diazepane and L7iso‐q2 = 1,4‐bis[(2‐isoquinolinyl)methyl]‐1,4‐diazepane} and describe X‐ray structures of corresponding manganese(II) compounds. Ground and excited state properties of these peroxomanganese(III) complexes, as well as previously reported [MnIII(O2)(L7py24‐Me)]+ and [MnIII(O2)(L7q2)]+ species {L7py24‐Me = 1,4‐bis[(4‐methyl‐2‐pyridyl)methyl]‐1,4‐diazepane and L7q2 = 1,4‐bis[(2‐quinolinyl)methyl]‐1,4‐diazepane} were probed using low‐temperature electronic absorption, magnetic circular dichroism (MCD), and variable‐temperature, variable‐field MCD spectroscopy. These data sets afford electronic transition energies and estimates of ground‐state zero‐field splitting parameters, which permit a detailed comparison of electronic structure. These data support the proposal that all complexes share a similar geometry, consisting of a side‐on peroxomanganese(III) moiety coordinated by the tetradentate ligand in a trans fashion. However, differences in d‐d transition energies offer conclusive evidence that, among this series of complexes, it is the location, and thus the steric influence, of the pyridine substituent that modulates the electronic and geometric structure of the MnIII‐O2 unit. Within this series, perturbations in electronic properties of the supporting ligand have little impact on d‐d transition energies. Models of peroxomanganese(III) complexes developed using density functional theory (DFT) computations support this proposal, and time‐dependent DFT computations qualitatively reproduce the experimental trend in d‐d transition energies.
CLA prevents alterations in glycolytic metabolites induced by a high fat diet
Authors: Andreoli María F. , Martinelli Marcela I. , Scalerandi María V. , Fariña Ana C. , Williner María R. , Bernal Claudio A. 
Published: February 2012

AbstractCLA has been reported to have beneficial and controversial effects on glucose and lipid metabolism. Besides, high fat (HF) diets induce alterations in liver and muscle lipid deposition, which could be associated with anomalous glucose utilization. Therefore, our aim was to evaluate whether the intake of CLA could prevent alterations in glycolytic intermediate metabolites and glycogen deposition induced by a HF diet. For this purpose, growing mice were fed a control diet (7% corn oil), a HF diet (20% corn oil), or a HF diet containing 17% corn oil + 3% CLA for 30 days. Liver and muscle glucose intermediate metabolites and glycogen were assessed. Liver glycolysis was inhibited by HF, reflected by a decreased flow of substrates through phosphofructokinase‐1α linked to elevated citrate. CLA at HF diet prevented these alterations while increasing the lactate and glycogen synthesis. In the muscle, the HF diet emphasized the reduction of the flux through phosphofructokinase‐1α, without additional changes in total glycogen levels. In conclusion, dietary CLA partially prevented glycolytic pathway alterations in the liver but not in the muscle of mice fed a HF diet, associated with adverse effects as sustained hyperglycemia and hepatic lactate accumulation.Practical applications: The present study evaluates the potential use of CLA and its consequences on several aspects of glucose metabolism. Considering that the FDA has recently approved CLA as a Generally Recognized as Safe (GRAS) category, a measure that will foster the commercial production of food and beverages with CLA supplementation, we believe it is relevant to study its potential functional properties on glucose metabolism in an experimental animal model characterized by alterations in liver and muscle lipid deposition.
High‐resolution genome‐wide copy‐number analysis suggests a monoclonal origin of multifocal prostate cancer
Authors: Boyd Lara K. , Mao Xueying , Xue Liyan , Lin Dongmei , Chaplin Tracy , Kudahetti Sakunthala C. , Stankiewicz Elzbieta , Yu Yongwei , Beltran Luis , Shaw Greg , Hines John , Oliver R. Tim D. , Berney Daniel M. , Young Bryan D. , Lu Yong‐Jie 
Published: February 2012

AbstractMany human cancers present as multifocal lesions. Understanding the clonal origin of multifocal cancers is of both etiological and clinical importance. The molecular basis of multifocal prostate cancer has previously been explored using a limited number of isolated markers and, although independent origin is widely believed, the clonal origin of multifocal prostate cancer is still debatable. We attempted to address clonal origin using a genome‐wide copy‐number analysis of individual cancer and high‐grade prostatic intraepithelial neoplasia (HGPIN) lesions. Using Affymetrix array 6.0 copy‐number analysis, we compared the genomic changes detected in 48 individual cancer and HGPIN lesions, isolated from 18 clinically localized prostate cancer cases. Identical genomic copy‐number changes, shared by all same‐case cancer foci, were detected in all 13 informative cases displaying multiple tumor foci. In addition, individual HGPIN lesions in the two multifocal‐HGPIN cases available shared identical genomic changes. Commonly known genomic alterations, including losses at 6q15, 8p21.3‐8p21.2, 10q23.2‐10q23.31, 16q22.3, 16q23.2‐16q23.3 and 21q22.2‐21q22.3 regions and gain of 8q24.3 were the most frequently detected changes in this study and each was detected in all same‐case foci in at least one case. Microarray data were confirmed by fluorescence in situ hybridization in selected foci. Our high‐resolution genome‐wide copy‐number data suggest that many multifocal cases derive from a single prostate cancer precursor clone and that this precursor may give rise to separate HGPIN foci and may further progress to multifocal invasive prostate cancer. These findings, which demonstrate the monoclonal origin of multifocal prostate cancer, should significantly enhance our understanding of prostate carcinogenesis. © 2012 Wiley Periodicals, Inc.