bluuebunny/crossref_metadata_2025_split huggingface dataset:
Uniforms affect the accuracy of children's eyewitness identification decisions
Authors: Lowenstein Joseph A. , Blank Hartmut , Sauer James D. 
Published: August 2009

AbstractA substantial proportion of line‐up identifications involving child eyewitnesses in the UK are conducted by police officers wearing uniform. This study examined the possibility that wearing a uniform constitutes an authority cue that adversely affects a child's ability to make accurate eyewitness identifications. Sixty participants aged 9–10 years old witnessed a staged crime and were later asked to identify a ‘burglar’ from a simultaneous line‐up using a 2 (uniform: present vs. absent) × 2 (target: present vs. absent) design. Children in the uniform present conditions made significantly more choices than children in the uniform absent conditions. More importantly, in the presence of a uniform, children made significantly more false identifications in target‐absent line‐ups. Analysis of supplementary, identification‐related variables (identification time and confidence, state anxiety) suggested that (1) the children experienced uncertainty if the target was absent from the line‐up, but (2) this uncertainty was not expressed when the line‐up administrator wore a uniform, leading to an increase in false identifications. Implications for line‐up administration procedures for children are discussed. Copyright © 2009 John Wiley & Sons, Ltd.
Sperm ultrastructure in Bathypolypus bairdii and B. sponsalis (Cephalopoda: Octopoda)
Authors: Roura Álvaro , Guerra Ángel , González Ángel F. , Pascual Santiago 
Published: August 2009

AbstractA morphological comparison of the spermatozoa of the octopods Bathypolypus bairdii and B. sponsalis has been carried out by electron microscopy. Although the mature spermatozoon of B. bairdii is longer and thinner than that of B. sponsalis, its general ultrastructure is similar except for some minor differences. Their characteristic acrosomes, described here for the first time, consist of a periodically banded cone surrounded by a double helix whose arrangement has been defined by a numeric expression. The plasma membrane of sponsalis that surrounds the acrosome has many projections filled with abundant granular cytoplasm, which appears as a star‐shaped acrosome in cross‐section. The mitochondrial sheath contains 9–11 mitochondria in bairdii but only 9 in sponsalis. A comparison with other Octopodidae shows that the nucleus of both species is the largest ever seen. Our results support the capability of sperm morphology to discriminate between species and could even discern at higher taxonomic levels. J. Morphol., 2010. © 2009 Wiley‐Liss, Inc.
Structural adaptation and intracortical bone turnover in an ovine model of osteoporosis
Authors: Healy Claragh , Kennedy Oran D. , Brennan Orlaith , Rackard Sue M. , O'Brien Fergal J. , Lee Thomas Clive 
Published: September 2009

AbstractCompact bone makes up approximately 80% of the human skeletal mass. This study examines the effect of estrogen deficiency on compact bone turnover and associated geometrical structural adaptation over a 31‐month period in a large animal model. Twenty‐seven skeletally mature sheep were divided into control (n = 16) and ovariectomy group (OVX, n = 11). Animals were administered five different fluorochrome dyes to label intracortical bone turnover, and sacrificed at 31 months. Compact bone samples were analyzed for cortical geometry, intracortical turnover at five time points, resorption cavities, porosity, and compressive strength. Intracortical bone turnover was significantly increased in OVX, which demonstrated seasonal variation. Cross‐sectional area in OVX was significantly greater than control and was associated with an increased section modulus. Intracortical porosity was significantly increased in OVX, however, there was no significant difference in ultimate compressive strength between the groups. Our results demonstrate increased intracortical bone turnover, resportion spaces, and porosity in OVX, without adversely affecting compressive strength. Our results also support the hypothesis of geometrical adaptation of compact bone in response to estrogen deficiency. These results suggest an early structural compensatory response in compact bone, despite increased intracortical turnover. © 2009 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 28:248–251, 2010
Enhanced healing of goat femur‐defect using BMP7 gene‐modified BMSCs and load‐bearing tissue‐engineered bone
Authors: Zhu Lian , Chuanchang Dai , Wei Liu , Yilin Cao , Jiasheng Dong 
Published: September 2009

AbstractSegmental defect regeneration is still a clinical challenge. In this study, we investigated the feasibility of bone marrow stromal cells (BMSCs) infected with adenoviral vector containing the bone morphogenetic protein 7 gene (AdBMP7) and load‐bearing to enhance bone regeneration in a critically sized femoral defect in the goat model. The defects were implanted with AdBMP7‐infected BMSCs/coral (BMP7 group) or noninfected BMSCs/coral (control group), respectively, stabilized with an internal fixation rod and interlocking nails. Bridging of the segmental defects was evaluated by radiographs monthly, and confirmed by biomechanical tests. Much callus was found in the BMP7 group, and nails were taken off after 3 months of implantation, indicating that regenerated bone in the defect can be remodeled by load‐bearing, whereas after 6 months in control group. After load‐bearing, it is about 5 months; the mechanical property of newly formed bone in the BMP7 group was restored, but 8 months in control group. Our data suggested that the BMP7 gene‐modified BMSCs and load‐bearing can promote bone regeneration in segmental defects. © 2009 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 28:412–418, 2010
Role of surgery in the treatment of ovarian metastases from colorectal cancer
Authors: Chung Tae‐Sung , Chang Hee Jin , Jung Kyung Hae , Park Sang‐Yoon , Lim Seok‐Byung , Choi Hyo Seong , Jeong Seung‐Yong 
Published: August 2009

AbstractBackground and ObjectivesThe role of surgical resection in the treatment of metastatic ovarian tumors originating from colorectal cancer (CRC) remains uncertain. We sought to identify a subgroup of patients who would benefit from surgical resection.MethodsWe analyzed the clinicopathological and follow‐up data on 34 patients who underwent surgical resection of metastatic ovarian tumors originating from CRC.ResultsSynchronous ovarian metastasis was detected in 27 patients (79.4%) and metachronous metastasis in 7 (20.6%). The histologic type of the primary CRC was adenocarcinoma in 26 patients (76.5%), mucinous carcinoma in 7 (20.6%), and signet ring cell carcinoma in 1 (2.9%). Complete cytoreduction was possible in 11 patients (32.4%). The 3‐year overall survival (OS) rate was 25.1%. The median OS time was 19 months (range, 2–64 months) in all patients, and 36 months (range, 10–64 months) in patients who underwent complete cytoreduction. Cox's proportional hazards analysis showed that unilateral ovarian metastasis (relative risk [RR], 0.405; 95% confidence interval [CI], 0.171–0.959) and metastasis confined to the pelvic cavity (RR, 0.165; 95% CI, 0.031–0.878) were significantly associated with favorable prognosis.ConclusionsSurgical resection may be beneficial in selected patients with ovarian metastasis arising from CRC, when metastasis is limited to the pelvis. J. Surg. Oncol. 2009;100:570–574. © 2009 Wiley‐Liss, Inc.
Comparative analysis of thymidylate synthase at the protein, mRNA, and DNA levels as prognostic markers in colorectal adenocarcinoma
Authors: Ren Dan‐Ni , Kim Ik‐Yong , Koh Sang Baek , Chang Sei Jin , Eom Minseob , Yi Sang Yeop , Seong Seung Hoon , Kim Mi‐Dong , Bronner Mary P. , Cho Mee‐Yon 
Published: August 2009

AbstractBackground and ObjectivesTo determine the best routinely available molecular methodology for assessing thymidylate synthase (TS) as a prognostic marker in colorectal adenocarcinoma, TS was examined at the protein, mRNA, and DNA levels. Direct comparison of these routinely available assays has not been systematically studied across a large colon cancer patient cohort with long‐term follow‐up.MethodsWe studied 150 surgically resected colorectal adenocarcinoma patients who received postoperative 5‐Fluorouracil (5‐FU) chemotherapy. TS immuunohistochemistry and real‐time quantitative RT‐PCR and PCR genotyping on patient‐matched tumor and normal tissues were performed.ResultsSurprisingly, mRNA values in normal tissue varied from 0.11 to 62.0 and significantly correlated with mRNA values of matched tumor tissues. Although higher tumor/normal ratios of mRNA expression trended toward poorer patient survival, neither this nor TS immunohistochemistry results were statistically significant predictors. TS tumor genotype was generally concordant with matched normal tissues. Further, the 2R/3R genotype of 5′‐TSER was significantly correlated with poorer patient survival (P = 0.0249) and was also an independent prognostic marker on multivariate analysis.ConclusionTS genotyping on paraffin‐embedded fixed tissues proved to be the most useful method for prediction of outcome of 5‐FU treatment in patients with colorectal adenocarcinoma. J. Surg. Oncol. 2009;100:546–552. © 2009 Wiley‐Liss, Inc.
Hyperbaric oxygen therapy for radiation‐induced brain necrosis in a patient with primary central nervous system lymphoma
Authors: Cihan Yasemin Benderli , Uzun Günalp , Yildiz Şenol , Dönmez Halil 
Published: August 2009

AbstractA 45‐year‐old man who developed brain radionecrosis in the right frontal and left temporoparietal lobes after receiving whole brain radiotherapy and stereotactic radiosurgery for primary central nervous system lymphoma. Since high dose steroid treatment failed and he declined to undergo surgery, he was referred to hyperbaric oxygen (HBO) therapy. Both clinical and radiological findings improved after HBO therapy. Steroid requirements were also reduced. HBO therapy may have a potential value in treatment of brain radionecrosis. J. Surg. Oncol. 2009;100:732–735. © 2009 Wiley‐Liss, Inc.
Survival analysis after pancreatic resection for ampullary and pancreatic head carcinoma: An analysis of clinicopathological factors
Authors: Sommerville C.A.M. , Limongelli P. , Pai M. , Ahmad R. , Stamp G. , Habib N.A. , Williamson R.C.N. , Jiao L.R. 
Published: August 2009

AbstractBackground and ObjectivesSurgery remains the only curative option for the treatment of pancreatic and ampullary carcinomas. To examine the survival differences between ampullary and pancreatic head carcinomas after pancreaticoduodenectomy.MethodsA retrospective review of patients with ampullary or pancreatic head adenocarcinoma undergoing curative resection during a 6‐year period prior to 2000.ResultsA total of 104 patients underwent pancreaticoduodenectomy for pancreatic head and ampullary carcinomas (n = 65 and n = 39, respectively). Histologically, pancreatic cancer was worse, with more lymph node involvement and more positive resection margins and vascular and perineural invasions than found in ampullary carcinoma. The median disease‐free and overall survival rates were significantly better for ampullary cancer when compared with pancreatic cancer (17 vs. 9 months [P = 0.001] and 35 vs. 24 months [P = 0.006], respectively). The actuarial 5‐year disease‐free and overall survival rates were 4.4% and 10.5%, respectively, for pancreatic carcinoma and 27.9% and 31.8%, respectively, for ampullary carcinoma. Multivariate analysis showed that microscopic resection margin involvement (P = 0.02) and involvement of over three nodes (P < 0.001) were significant factors affecting the overall survival for pancreatic and ampullary carcinomas, respectively.ConclusionsIn this study, patients with ampullary carcinoma have a better prognosis and survival than those with pancreatic carcinoma. J. Surg. Oncol. 2009;100:651–656. © 2009 Wiley‐Liss, Inc.
Lipopolysaccharide (LPS) increases the invasive ability of pancreatic cancer cells through the TLR4/MyD88 signaling pathway
Authors: Ikebe Mio , Kitaura Yoshiki , Nakamura Masafumi , Tanaka Haruo , Yamasaki Akio , Nagai Shuntaro , Wada Junji , Yanai Kosuke , Koga Kenichiro , Sato Norihiro , Kubo Makoto , Tanaka Masao , Onishi Hideya , Katano Mitsuo 
Published: August 2009

AbstractBackgroundInflammation plays a multifaceted role in cancer progression, and NF‐κB is one of the key factors connecting inflammation with cancer progression. We have shown that lipopolysaccharide (LPS) promotes NF‐κB activation in colon cancer cells and pancreatic cancer cells. However, it is unclear why inflammatory stimuli can induce NF‐κB activation in cancer cells.MethodsWe used two human pancreatic cancer cells, Panc‐1 and AsPC‐1, as target cells. LPS was used as an inflammatory stimulus. To confirm the participation of TLR4/NF‐κB signaling pathway, we used three different NF‐κB inhibitors (PDTC, IκBα mutant, and NF‐κB decoy ODN) and siRNAs (against TLR4, MyD88, and MMP‐9). Effect of LPS on pancreatic cancer cell invasive ability was determined by Matrigel invasion assay.ResultsLPS increased the invasive ability of pancreatic cancer cells, while blockade of NF‐κB pathway decreased the LPS‐dependent increased invasive ability. Blockade of TLR4 or MyD88 by siRNA also decreased the LPS‐dependent increased invasive ability.ConclusionThese results suggest that TLR/MyD88/NF‐κB signaling pathway plays a significant role in connecting inflammation and cancer invasion and progression. J. Surg. Oncol. 2009;100:725–731. © 2009 Wiley‐Liss, Inc.
Role of the surgeon as a variable in long‐term survival after liver resection for colorectal metastases
Authors: Giuliante Felice , Ardito Francesco , Vellone Maria , Ranucci Giuseppina , Federico Bruno , Giovannini Ivo , Nuzzo Gennaro 
Published: August 2009

AbstractBackground and ObjectivesSurvival analyses after hepatectomy for colorectal liver metastases (CRLM) mostly address tumor‐related factors; this study has simultaneously evaluated interventional factors which may be influenced by the surgeon.MethodsOperative and long‐term results of 251 consecutive patients undergoing hepatectomy for CRLM between 1992 and 2007 were analyzed.ResultsMortality was 0.8%, morbidity 22.9%, intraoperative blood transfusion rate 23.1% (19.4% with pedicle clamping, 35.0% without clamping, P = 0.01), R0‐resection 93.6% (2/3 with tumor‐free margin >5 mm). The 3‐, 5‐, 10‐year overall and disease‐free survival rates were 55.2%, 38.9%, 24.2%, and 37.1%, 28.2%, 25.4%. Univariate analysis: lower survival was related to transfusion requirement, tumor size >5 cm, tumor‐free margin ≤5 mm, major hepatectomy, R1‐resection, multiplicity of CRLM, preoperative CEA ≥50 ng/ml. Multivariate analysis: intraoperative transfusion remained the only independent predictor of survival; tumor‐free margin ≤5 mm and multiplicity of CRLM remained independent predictors of disease‐free survival within 12 months from hepatectomy; intraoperative transfusion became again the prominent predictor for later recurrences.ConclusionsTwo factors may be influenced by the surgeon: bleeding with requirement for blood transfusion (through the protective effect of pedicle clamping) and width of tumor‐free surgical margin. These factors have prominent roles on long‐term outcomes after hepatectomy for CRLM. J. Surg. Oncol. 2009;100:538–545. © 2009 Wiley‐Liss, Inc.
Determination of banned Sudan dyes in food samples by molecularly imprinted solid phase extraction‐high performance liquid chromatography
Authors: Baggiani Claudio , Anfossi Laura , Baravalle Patrizia , Giovannoli Cristina , Giraudi Gianfranco , Barolo Claudia , Viscardi Guido 
Published: August 2009

AbstractA method for molecularly imprinted SPE of banned Sudan azo‐dyes from food samples was investigated. The molecularly imprinted polymer was obtained by suspension polymerization using 1‐(4‐chlorophenyl)azonaphthalen‐2‐ol as the mimic template. The molecular recognition properties of imprinted beads were evaluated for use as a SPE sorbent, in order to develop a selective extraction protocol for the Sudan class of dyes. The optimized extraction protocol resulted in a reliable molecularly imprinted SPE (MISPE) method suitable for HPLC analysis. It was selective for the main analyte, Sudan I, and the related azo‐dyes Sudan II, III, IV, Sudan Red B, and Sudan Red 7B, while the permitted azo‐dyes Allura Red AC, Neococcin, and Sunset Yellow FCF were not extracted. The method was tested for Sudan I, II, III, and IV in five different food samples (hot chilli pepper, hot chilli tomato sauce, sausage, tomato sauce, and hard boiled egg yolk) at three concentration levels (15, 100, and 300 μg/g). It demonstrated itself to be insensitive to the presence of different complex matrices, precise, accurate, and with good recovery rates (85–101%). The LOD and LOQ were satisfactory for most analytical determinations.
Quartz crystal microbalance for the detection of carbaryl using molecularly imprinted polymers as recognition element
Authors: Yao Wei , Gao Zhixian , Cheng Yiyong 
Published: August 2009

AbstractA new piezoelectric quartz crystal sensor using molecularly imprinted polymers (MIPs) as recognition element has been prepared for the fast detection of carbaryl. The MIPs were prepared by precipitation polymerization in ACN, and then the polymer particles were fixed on the surface of the electrode. Computer simulation technology was employed to investigate the interaction between carbaryl and methacrylic acid (MAA) for elucidating the recognition mechanism. Scanning electron microscopy (SEM) and atomic force microscopy (AFM) were employed to evaluate the obtained imprinted polymer particles and the MIP sensitive film coated on the electrode. The sensor developed exhibits a liner relationship between the frequency shift and carbaryl concentration in the range of 10–1000 ng/mL (y = 0.139 x + 2.99, r = 0.9981), and the detection limit was 12.5 ng/mL (S/N = 3). Furthermore, the influencing factors were investigated, and the experiments indicated that the obtained sensor has high sensitivity, excellent selectivity, good reproducibility, and reusable property.
Molecularly imprinted solid‐phase extraction of cephalexin from water‐based matrices
Authors: Beltran Antoni , Fontanals Núria , Marcé Rosa M. , Cormack Peter A. G. , Borrull Francesc 
Published: August 2009

AbstractIn the present paper, we describe the synthesis of a cephalexin (CFX) molecularly imprinted polymer (MIP), the direct application of the MIP to SPE for the determination of CFX (which is a β‐lactam antibiotic) in human urine and the use of the MIP in a tandem SPE system to determine CFX in river water. The molecularly imprinted polymers (MIP) showed cross‐selectivity for amoxicillin (AMX; also a β‐lactam antibiotic). This allowed both CFX and AMX to be quantified in acidified human urine, with recoveries of 78 and 60% for CFX and AMX, respectively, when the urine samples were spiked with CFX and AMX at 4 mg/L. These analyses were facile because the molecularly imprinted solid‐phase extraction (MISPE) extracts were clear compared to the nonpurified samples. In order to increase the sample volume for river water analyses, a tandem SPE system incorporating a commercially available sorbent was implemented. With this set‐up, CFX was determined with recoveries in excess of 50% when 200 mL of acidified river water samples spiked at 10 μg/L with CFX were percolated through the tandem system.
Hybrid molecularly imprinted membranes for targeted tocopherol: Uses of cross‐linked copolymer particles prepared by surfactant‐free dispersion technique
Authors: Kobayashi Takaomi , Faizal Che ku M. , Son Le Trung 
Published: August 2009

Abstractα‐Tocopherol (α‐Toc) targeted membrane adsorbents were prepared by mixing α‐Toc imprinted particles in polysulfone (PSf) scaffold. The α‐Toc imprinted particles were prepared with high‐shear dispersion copolymerization of α‐Toc methacrylate (α‐TMA) and divinylbenzene (DVB) in toluene and water in the agitation range of 300–13 500 rpm. The α‐Toc groups in resultant imprinted particles were hydrolyzed with 2 M HCl and then the polymers were embedded in PSf membranes by phase inversion technique. The membrane exhibited good selective binding of α‐Toc with high separation factors to its analogs.
Solid‐phase extraction of melamine from aqueous samples using water‐compatible molecularly imprinted polymers
Authors: He Limin , Su Yijuan , Shen Xiangguang , Zheng Yaqiu , Guo Hongbin , Zeng Zhenling 
Published: August 2009

AbstractA method for molecularly imprinted SPE of the melamine from environmental water samples was investigated. Cyromazine‐imprinted polymers were synthesized in water–methanol systems for the selective extraction of melamine from aqueous samples, followed by HPLC analysis. Molecular recognition properties and binding capability to melamine were evaluated by adsorption test and Scatchard analysis, which showed the dissociation constant (KD) and the maximum binding quantity (Qmax) were 0.032 μmol/L and 4.77 μmol/g for high affinity binding site, and 0.26 μmol/L and 19.10 μmol/g for lower affinity binding site, respectively. Under the optimum extraction protocol, the method can be successfully applied to selectively extract and enrich melamine in environmental water. The linearity was ranged from 0.500 to 100.0 ng/mL (r > 0.999) in tap water, lake water, and seawater analysis. When 50 mL of the water samples loaded, the LODs of the method were ca. 0.1 ng/mL, and the LOQs were ca. 0.5 ng/mL. The mean recoveries of melamine from blank water samples spiked at 0.5, 5.0, and 50 ng/mL were more than 86.3%, with the RSD less than 8.8%.
Liquid Crystals Embedded in Polymeric Electrolytes for Quasi‐Solid State Dye‐Sensitized Solar Cell Applications
Authors: Kim Sung Chul , Song Myungkwan , Ryu Tae In , Lee Myung Jin , Jin Sung‐Ho , Gal Yeong‐Soon , Kim Hyeon‐Kyung , Lee Gi‐Dong , Kang Yong Soo 
Published: September 2009

AbstractA new series of liquid crystal embedded in polymeric electrolytes was developed for obtaining high efficiency in quasi‐solid state dye‐sensitized solar cells (DSSCs). The polymeric electrolytes were composed of iodide and tri‐iodide redox species in polyacrylonitrile (PAN) as a polymer matrix and liquid crystals (E7 or ML‐0249) for increasing the order parameter of electrolyte components with easy transport of redox species. The highest efficiency (6.21 and 6.29% at 1 sun) was obtained for the quasi‐solid state DSSCs using E7 to PAN and ML‐0249 to PAN, respectively, under AM 1.5 G illumination and an aperture mask condition. The high efficiencies of the quasi‐solid state DSSCs are due to the effective formation of pathways through liquid crystal orientation for the transport of redox species.magnified image
Polybenzimidazoles (PBIs) Derived from Non‐Coplanar Dibenzoic Acid Containing Imidazole (IDBA): Synthesis, Characterization and Properties
Authors: Liang Zhumei , Jiang Xuesong , Xu Hongjie , Chen Dan , Yin Jie 
Published: September 2009

AbstractA novel non‐coplanar imidazole dibenzoic acid (IDBA) was successfully prepared, and its structure was carefully characterized by FT‐IR, NMR, MS and elemental analysis. Polybenzimidazoles (PBIs) derived from IDBA were synthesized by a conventional one‐step method in polyphosphoric acid (PPA). The obtained PBIs exhibited good organic solubility, excellent thermo‐stability and interesting optical properties. The initiation decomposition temperature for these PBIs ranged from 560–600 °C, and the 5% weight loss temperature (T5) for all these PBIs was above 600 °C in N2. No obvious glass transition for these PBIs was observed below 350 °C. These PBIs shows UV‐vis absorption maximum around 360–380 nm and strong photoluminescence emission (blue light) around 430–440 nm in solution, which is red‐shifted to 490–510 nm in the solid state.magnified image