bluuebunny/crossref_metadata_2025_split huggingface dataset:
Seismic performance evaluation of precast post-tensioned high-performance concrete frame beam-column joint under cyclic loading
Authors: Pang Xuefei , Li Yangchun 
Published: May 2024

AbstractPrecast concrete structures have developed rapidly because they meet the requirements of green and low-carbon social development. In this paper, a precast post-tensioned high-performance concrete frame beam-column joint was proposed, and the low-cycle reversed load test was performed on the four proposed joints. The main differences between the four joints are the different prestress values applied by the joints and whether the beam-column joint is provided with L-shaped steel. The seismic performance indexes such as hysteresis curve, stiffness degradation, deformation capacity, energy dissipation capacity and residual deformation of each node were obtained through experiments. By comparing various seismic performance indicators, it could be found that the use of high-performance concrete could effectively avoid the phenomenon of local crushing of concrete due to excessive prestressing. At the same time, it was found that the setting of L-shaped steel plate at the beam-column junction could effectively avoid the early damage at the beam-column junction. On the basis of the test, the three-line restoring force model of the joint was established by the method of experimental regression analysis. The model could better reflect the stress situation of each stage of the joint. Based on the experimental and theoretical analysis, the finite element analysis model of the joint was established, and the model calculation results were in good agreement with the experimental results.
The mediating role of synovitis in meniscus pathology and knee osteoarthritis radiographic progression
Authors: Deng Hui , Chen Zhijun , Kang Jiawei , Liu Jun , Chen Shenliang , Li Mingzhang , Tao Jun 
Published: May 2024

AbstractMeniscus pathologies (damage, extrusion) and synovitis are associated with knee osteoarthritis (KOA); however, whether synovitis mediates the relationship between meniscus pathologies and KOA radiographic progression remains unclear. We conducted an observational study in the Osteoarthritis Initiative (OAI) cohort, with a 48-month follow-up. Meniscus pathology and synovitis were measured by MRI osteoarthritis knee score (MOAKS) at baseline and 24 months, and a comprehensive synovitis score was calculated using effusion and Hoffa synovitis scores. The knee osteoarthritis radiographic progression was considered that Kellgren–Lawrence (KL) grade and joint space narrowing (JSN) grade at 48 months were increased compared to those at baseline. This study included a total of 589 participants, with KL grades mainly being KL1 (26.5%), KL2 (34.1%), and KL3 (30.2%) at baseline, while JSN grades were mostly 0 at baseline. A logistic regression model was used to analyze the relationship between meniscus pathology, synovitis, and KOA progression. Mediation analysis was used to evaluate the mediation effect of synovitis. The average age of the participants was 61 years old, 62% of which were female. The medial meniscus extrusion was longitudinally correlated with the progression of KL (odds ratio [OR]: 2.271, 95% confidence interval [CI]: 1.412–3.694) and medial JSN (OR: 3.211, 95% CI: 2.040–5.054). Additionally, the longitudinal correlation between medial meniscus damage and progression of KOA (OR: 1.853, 95% CI: 1.177–2.941) and medial JSN (OR: 1.655, 95% CI: 1.053–2.602) was significant. Synovitis was found to mediate the relationship between medial meniscus extrusion and KL and medial JSN progression at baseline (β: 0.029, 95% CI: 0.010–0.053; β: 0.022, 95% CI: 0.005–0.046) and beyond 24 months (β: 0.039, 95% CI: 0.016–0.068; β: 0.047, 95% CI: 0.020–0.078). However, we did not find evidence of synovitis mediating the relationship between meniscal damage and KOA progression. Synovitis mediates the relationship between medial meniscus extrusion (rather than meniscus damage) and KOA progression.
Catalysing cooperation: the power of collective beliefs in structured populations
Authors: Fic Małgorzata , Gokhale Chaitanya S. 
Published: May 2024

AbstractCollective beliefs can catalyse cooperation in a population of selfish individuals. We study this transformative power of collective beliefs, an effect that intriguingly persists even when beliefs lack moralising components. Besides the process itself, we consider the structure of human populations explicitly. We incorporate the intricate structure of human populations into our model, acknowledging the bias brought by social and cultural identities in interaction networks. Hence, we develop our model by assuming a heterogeneous group size and structured population. We recognise that beliefs, typically complex story systems, might not spontaneously emerge in society, resulting in different spreading rates for actions and beliefs within populations. As the degree of connectedness can vary among individuals perpetuating a belief, we examine the speed of trust build-up in networks with different connection densities. We then scrutinise the timing, speed and dynamics of trust and belief spread across specific network structures, including random Erdös-Rényi networks, scale-free Barabási-Albert networks, and small-world Newman-Watts-Strogatz networks. By comparing these characteristics across various network topologies, we disentangle the effects of structure, group size diversity, and evolutionary dynamics on the evolution of trust and belief.
Stellenwert der endomyokardialen Biopsie in der Diagnostik und Therapie der Kardiomyopathien
Authors: Schultheiss Heinz-Peter , Baumeier Christian 
Published: May 2024

ZusammenfassungKardiomyopathien sind eine der wesentlichen Ursachen einer progredienten Herzinsuffizienz. Aufgrund ihrer großen klinischen Relevanz sind neue Diagnoseverfahren von eminenter Bedeutung. Neben der häufigsten Ursache von Kardiomyopathien – myokardiale Entzündung und/oder Virusinfektion – können zahlreiche andere Faktoren wie metabolische, toxische, rheumatische, endokrine, infiltrative und genetische Faktoren an der Entstehung einer Herzmuskelerkrankung beteiligt sein. Da eine korrekte Diagnose mit nicht invasiven Methoden einschließlich moderner bildgebender Verfahren nicht möglich ist, stellt die Endomyokardbiopsie weiterhin den diagnostischen Goldstandard als Voraussetzung für eine kausale, spezifische und personalisierte Therapie dar.
Kardiomyopathie-Phänotypen – Unterschiede und Gemeinsamkeiten in der Behandlung
Authors: Bittner Daniel , Raake Philip 
Published: May 2024

ZusammenfassungStrukturelle und funktionelle Veränderungen des Herzmuskels definieren Kardiomyopathien, die sich bildmorphologisch in 5 verschiedene Phänotypen einteilen lassen. Aufgrund u. a. hämodynamischer Unterschiede der verschiedenen Phänotypen unterscheidet sich auch deren Therapie. So existieren für einige Kardiomyopathien spezielle medikamentöse Therapien, für andere hingegen stützt sich die Therapie auf eine unspezifische Herzinsuffizienztherapie. Allerdings gilt es, auch bei Letztgenannter, Unterschiede in der Behandlung zu beachten. Neben der medikamentösen Therapie können auch in Einzelfällen mithilfe einer kardialen Device-Therapie – wie z. B. der Schrittmachertherapie – positive Effekte erzielt werden, allerdings wiederum abhängig vom jeweiligen Phänotyp. Auch hinsichtlich der Primärprävention eines plötzlichen Herztods unterscheidet sich das Vorgehen, bei der neben der Phänotypisierung auch die Genotypisierung eine wichtige Rolle spielt. Diese Gründe bekräftigen die
Notwendigkeit der Differenzierung verschiedener Kardiomyopathien.
Clinical and Surgical Evaluation of Sentinel Node Biopsy in Patients with Early-Stage Endometrial Cancer and Atypical Hyperplasia
Authors: Pöschke Patrik , Gass Paul , Krückel Annika , Keller Katharina , Erber Ramona , Hartmann Arndt , Beckmann Matthias W. , Emons Julius 
Published: May 2024

AbstractThe medical and surgical treatment of endometrial cancer (EC) is evolving toward a more patient-centered and personalized approach. The role of laparoscopic sentinel node biopsy (SNB) for early-stage EC is unclear, and very few data are available for atypical endometrial hyperplasia (AEH). The present study investigated the effectiveness of SNB combined with laparoscopic hysterectomy in patients with early-stage EC and AEH.This was a retrospective, single-center cohort study for the period from January 2018 to December 2023. A total of 102 patients with atypical hyperplasia (n = 20) and early-stage EC (n = 82) findings on diagnostic curettage underwent pelvic sentinel node biopsy during the final operation.Eleven patients (55%) who had initially been diagnosed with AEH were found to have EC in the final pathology report. No lymph node metastases were detected in patients who had initially been diagnosed with AEH; a 3.6% rate of positive SNBs was found in patients with EC. Changes in tumor grade occurred in 31.3% of the patients and changes in FIGO stage in 33%. Bilateral sentinel node (SN) mapping was successful in 94.1% of the patients. The postoperative outcomes were comparable to those of routine clinical practice without SNB.SNB can be safely offered to patients who have precursor lesions and early-stage EC without notably extending surgical times or increasing postoperative morbidity. This approach can be considered and is safe for patients diagnosed with AEH, but it appears to have a rather small impact on these patients.
Sleep Inertia als Herausforderung für die kommerzielle Luftfahrt
Authors: Fischer Dorothee , Benderoth Sibylle , Elmenhorst Eva-Maria 
Published: May 2024

ZUSAMMENFASSUNGNeueste Entwicklungen in Technologie und Automatisierung lassen das kommerzielle Fliegen mit minimaler Besatzung, sog. extended Minimum Crew Operations (eMCOs), möglich erscheinen. In eMCOs hat während des Reiseflugs ein Pilot die Kontrolle (Pilot Flying), während der andere sich in einer Ruhephase befindet (Pilot Resting). In einem Notfall kann es passieren, dass der Pilot Resting aus dem Schlaf heraus die Kontrolle übernehmen muss. In diesem Fall steht er unter dem Einfluss von Sleep Inertia (zu Deutsch: Schlafträgheit), die das kognitive Leistungsvermögen stark beeinträchtigen kann. Es muss daher geprüft werden, inwiefern ein Pilot unter Sleep Inertia in der Lage ist, die an ihn gestellten Aufgaben sicher zu bearbeiten. In diesem Übersichtsartikel beleuchten wir Einflussfaktoren von Sleep Inertia; Herausforderungen, die Sleep Inertia an die Luftfahrt stellt; Studien zu kognitiven Leistungseinbußen durch Sleep Inertia bei Piloten; und potenzielle Gegenmaßnahmen.
Update Breast Cancer 2024 Part 1 – Expert Opinion on
Advanced Breast Cancer
Authors: Würstlein Rachel , Kolberg Hans-Christian , Hartkopf Andreas D. , Fehm Tanja N. , Welslau Manfred , Schütz Florian , Fasching Peter A. , Janni Wolfgang , Witzel Isabell , Thomssen Christoph , Krückel Annika , Belleville Erik , Lüftner Diana , Untch Michael , Thill Marc , Hörner Manuel , Tesch Hans , Ditsch Nina , Lux Michael P. , Aktas Bahriye , Banys-Paluchowski Maggie , Taran Florin-Andrei , Wöckel Achim , Harbeck Nadia , Stickeler Elmar , Bartsch Rupert , Schneeweiss Andreas , Ettl Johannes , Krug David , Müller Volkmar 
Published: May 2024

AbstractClinical evidence is interpreted based on clinical studies and personal
experience which can lead to different interpretations of data. This makes the
opinions issued by panels of experts such as the Advanced Breast Cancer Panel
which convened in November 2023 for the seventh time (ABC7) particularly
important. At the conference, current issues around advanced breast cancer were
evaluated by an international team of experts.In 2023 the data on CDK4/6 inhibitors was so extensive that the answers to
questions about the sequencing of therapy and the potential use of chemotherapy
as an alternative therapy were relatively clear. Moreover, data on antibody drug
conjugates which provides a good overview of their uses is available for all
molecular subtypes.Some therapeutic settings, including patients with brain metastases or
leptomeningeal disease, older patients, locally advanced breast cancer and
visceral crises, continue to be particularly important and were discussed in
structured sessions. The scientific context of some of the topics discussed at
ABC7 is presented and assessed here.
Anomalies of Midbrain/Hindbrain Development and Related Disabilities: Pontocerebellar Hypoplasia, Congenital Disorders of Glycosylation, and Cerebellar Hemisphere Hypoplasia
Authors: Gulino Alessandro , Dierna Federica , Zanghì Antonio , Vecchio Michele , Salafia Stefania , Marino Francesco , Foti Pietro , Belfiore Giuseppe , Basile Antonio , Ruggieri Martino , Polizzi Agata 
Published: May 2024

AbstractRecent progress in developmental biology, molecular genetics, and neuroimaging has enabled a more profound comprehension of developmental disorders affecting the embryonic midbrain and hindbrain, which manifest clinically. The purpose of this review is to describe anomalies of the midbrain/hindbrain such as pontocerebellar hypoplasia (PCH), congenital disorders of glycosylation (CDG), cerebellar hemisphere hypoplasia. PCH is a group of disorders that is both clinically and genetically diverse. These disorders are identified by the hypoplasia and degeneration of the cerebellum and ventral pons. A total of 18 distinct clinical subtypes of PCH, each linked to pathogenic variants in 19 different genes, have been documented, like mutations in TSEN54 (coding a subunit of tRNA splicing endonucleases complex) and TBC1D23 which display moderate-to-severe intellectual disability (ID) and microcephaly. CDG represent a set of inherited conditions marked by impaired glycosylation of proteins and lipids. The most prevalent subtype among CDG is PMM2-CDG, inherited in a recessive manner, causing reduced activity of phosphomannomutase. Its phenotype varies from mild to severe, involving the central nervous system and affecting many other organs as well. Patients who are severely affected also exhibit visceral symptoms alongside severe ID and other neurological manifestations. Cerebellar hypoplasia (CH) is characterized by a cerebellum of diminished volume while maintaining its shape. CH exhibits a diverse range of neuroradiologic features, etiologies, clinical characteristics, and neurodevelopmental involvement. Cerebello–oculo–facio–genital syndrome is linked to a recessive MAB21L1 mutation. Jubert's syndrome, associated with a rare autosomal recessive mutation, is identified on magnetic resonance imaging by cerebellar worm hypoplasia and midbrain malformations. The rhombencephalosynapsis, characterized by vermian agenesis or hypogenesis with the fusion of the cerebellar hemispheres, emerges during embryogenesis. It can manifest alone or in conjunction with other and/or extracerebral abnormalities.
Asymptotics of the sticky particles evolution
Authors: Hynd Ryan , Tudorascu Adrian 
Published: May 2024

Abstract
We study the long-time asymptotic behavior of the Sticky Particles dynamics on the real line. The time average of the Sticky Particles Lagrangian map has a limit which arises as a general property of projections onto closed convex cones in Hilbert spaces. More notably, we prove that the map itself has an asymptotic limit in the case where the sticky particles dynamics is confined to a compact set.
Static sphere observers and geodesics in Schwarzschild-de Sitter spacetime
Authors: Faruk Mir Mehedi , Morvan Edward , van der Schaar Jan Pieter 
Published: May 2024

Abstract
We analyze null- and spacelike radial geodesics in Schwarzschild-de Sitter spacetime connecting two conjugate static sphere observers, i.e. free-falling observers at a fixed radius in between the two horizons. We explicitly determine the changes in the causal structure with respect to these natural observers as a result of the inward bending of the black hole singularity, as well as the outward bending of asymptotic infinity. Notably, the inward and outward bending changes as a function of the black hole mass, first increasing towards a maximum and then decreasing to vanish in the extreme Nariai limit. For a generic mass of the black hole this implies the existence of finite size (temporal) windows for the presence of symmetric radial geodesics between the static sphere observers probing the interior region of the black hole, as well as the exterior de Sitter region. We determine the size of the interior (black hole) and exterior (de Sitter) temporal windows in 4, 5 and 6 spacetime dimensions, finding that they are equal in D = 5, and compute the proper lengths of the symmetric radial geodesics. We comment on the implications for information exchange and the potential role of the symmetric radial geodesics in a geodesic approximation of static sphere correlators in Schwarzschild-de Sitter spacetime.
Energetic particles transport in constants of motion space due to collisions in tokamak plasmas
Authors: Meng Guo , Lauber Philipp , Lu Zhixin , Bergmann Andreas , Schneider Mireille 
Published: May 2024

Abstract
The spatio-temporal evolution of the energetic particles in the transport time scale in tokamak plasmas is a key issue of the plasmas confinement, especially in burning plasmas. In order to include sources and sinks and collisional slowing down processes, a new solver, ATEP-3D was implemented to simulate the evolution of the energetic particle (EP) distribution in the three-dimensional constants of motion (CoM) space. The Fokker–Planck collision operator represented in the CoM space is derived and numerically calculated. The collision coefficients are averaged over the unperturbed orbits to capture the fundamental properties of EPs. ATEP-3D is fully embedded in ITER IMAS framework and combined with the LIGKA/HAGIS codes. The finite volume method and the implicit Crank-Nicholson scheme are adopted due to their optimal numerical properties for transport time scale studies. ATEP-3D allows the analysis of the particle and power balance with the source and sink during the transport process to evaluate the EP confinement properties.
Investigating the impact of initial parameters on autonomous robot swarm movement strategies for enhanced exploration efficiency: a comprehensive study
Authors: Karadağ Kübra , Tamer Özgür 
Published: May 2024

Abstract
Swarm robots are frequently preferred for the exploration of harsh environments and search and rescue operations. This study explores the factors that influence the movement strategies of autonomous robot swarms and their impact on swarm distribution in the field, employing simulation-based analysis. The research consists of two parts: initially, robots undergo free-fall as passive entities, followed by a phase where they employ predefined movement strategies from their fall positions. The study aims to investigate how the initial position and related parameters affect movement characteristics and the ultimate swarm distribution. To achieve this objective, four parameters-radius, height, mass, and the Coefficient of Restitution-were identified, each assigned three different values. The study observes the effects of these parameters on robot motion, considering motion strategies such as Random Walk, Levy Walk, Markov Process, and Brownian Motion. Results indicate that increasing parameter values induce changes in the position values of the free-falling swarm in the first part, which is the initial position for the second part, influencing movement strategies in diverse ways. The outcomes are analyzed concerning the radial and angular spread of the robots. Radial spread measures how far swarm elements spread from their initial positions, while angular spread indicates how homogeneously the robots are distributed according to the polar angle. The study comprehensively investigates how the movement strategies of autonomous robot swarms are impacted by parameters and how these effects manifest in the results. The findings are anticipated to enhance the effective utilization of autonomous robot swarms in exploration missions.
The Kondo effect in the quantum XX spin chain
Authors: Kattel Pradip , Tang Yicheng , Pixley J H , Andrei Natan 
Published: May 2024

Abstract
We investigate the boundary phenomena that arise in a finite-size XX spin chain interacting through an XX interaction with a spin

−

1
2

impurity located at its edge. Upon Jordan–Wigner transformation, the model is described by a quadratic Fermionic Hamiltonian. Our work displays, within this ostensibly simple model, the emergence of the Kondo effect, a quintessential hallmark of strongly correlated physics. We also show how the Kondo cloud shrinks and turns into a single particle bound state as the impurity coupling increases beyond a critical value. In more detail, using both Bethe Ansatz and exact diagonalization techniques, we show that the local moment of the impurity is screened by different mechanisms depending on the ratio of the boundary and bulk coupling

J

imp

J

. When the ratio falls below the critical value

2

, the impurity is screened via the Kondo effect. However, when the ratio between the coupling exceeds the critical value

2

an exponentially localized bound mode is formed at the impurity site which screens the spin of the impurity in the ground state. We show that the boundary phase transition is reflected in local ground state properties by calculating the spinon density of states, the magnetization at the impurity site in the presence of a global magnetic field, and the finite temperature susceptibility of the impurity. We find that the spinon density of states in the Kondo phase has the characteristic Lorentzian peak that moves from the Fermi level to the maximum energy of the spinon as the impurity coupling is increased and becomes a localized bound mode in the bound mode phase. Moreover, the impurity magnetization and the finite temperature impurity susceptibility behave differently in the two phases. When the boundary coupling

J

imp

exceeds the critical value

2

J

, the model is no longer boundary conformal invariant as a massive bound mode appears at the impurity site.
Defining Wellness-Focused Design for Rural Tourism: Study Case of Penanggungan Village
Authors: Sunarya W , Avenzoar A , Utomo H P 
Published: May 2024

Abstract
Rural tourism has great potential in enhancing the local welfare in Indonesia regions. It offers natural environment and authentic experience for tourists in improving health and wellbeing. Architectural design can play an important role to promote wellness in rural tourism as a branding strategy. Healthy design guidelines are required to enhance healthy benefits of rural living without neglecting the local culture and identity. Thus, wellness-focused design of tourism village should consider contextual aspects aligned with vernacular design principles. This study investigates how rural tourism can promote wellness through architectural design ideation considering vernacular principles. It aims to formulate wellness-focused design concept of tourism village based on a case study of Penanggungan village, Mojokerto, Indonesia. Literature study was carried out to conceptualize the basic design concepts of healthy rural tourism. Field observations and interviews were also conducted to contextualize the findings from literature study. This study produces design principles for developing healthy tourism village: (1) Healthy Product as a core of agrotourism, (2) Healthy Environment signifying attachment on nature, (3) Healthy Lifestyle reflecting the enjoyment of simple rural life, and (4) Healthy image as an icon representing healthy rural life. The implementation of these design principles is also discussed.