bluuebunny/crossref_metadata_2025_split huggingface dataset:
The spectrum of movement disorders in Glut‐1 deficiency
Authors: Pons Roser , Collins Abbie , Rotstein Michael , Engelstad Kristin , De Vivo Darryl C 
Published: January 2010

AbstractTo assess the spectrum of movement disorders, we reviewed video recordings and charts of 57 patients with Glut‐1 deficiency. Eighty‐nine percent of patients with Glut‐1 deficiency syndrome had a disturbance of gait. The most frequent gait abnormalities were ataxic‐spastic and ataxic. Action limb dystonia was observed in 86% of cases and mild chorea in 75%. Cerebellar action tremor was seen in 70% of patients, myoclonus in 16%, and dyspraxia in 21%. Nonepileptic paroxysmal events occurred in 28% of patients, and included episodes of ataxia, weakness, Parkinsonism and nonkinesogenic dyskinesias. The 40 patients (70%) who were on the ketogenic diet had less severe gait disturbances but more dystonia, chorea, tremor, myoclonus, dyspraxia, and paroxysmal events compared with the 17 patients on a conventional diet. Poor dietary compliance and low ketonuria appear to trigger the paroxysmal events in some patients. Gait disturbances and movement disorders are frequent in patients with Glut‐1 deficiency and are signs of chronic and intermittent pyramidal, cerebellar and extrapyramidal circuit dysfunction. These clinical symptoms reflect chronic nutrient deficiency during brain development and may be mitigated by chronic ketosis. © 2009 Movement Disorder Society
Orodispersible sublingual piribedil to abort OFF episodes: A single dose placebo‐controlled, randomized, double‐blind, cross‐over study
Authors: Rascol Olivier , Azulay Jean‐Philippe , Blin Olivier , Bonnet Anne‐Marie , Brefel‐Courbon Christine , Césaro Pierre , Damier Philippe , Debilly Bérengère , Durif Frank , Galitzky Monique , Grouin Jean‐Marie , Pennaforte Sylvie , Villafane Gabriel , Yaici Sadek , Agid Yves 
Published: January 2010

AbstractS90049, a novel sublingual formulation of the non‐ergoline D2‐D3agonist piribedil, has a pharmacokinetic profile promising to provide rapid relief on motor signs in Parkinson's disease (PD). We assessed the efficacy and safety of S90049 in aborting OFF episodes responding to subcutaneous apomorphine in PD patients with motor fluctuations. This was a single‐dose double‐blind double‐placebo 3 × 3 cross‐over study. Optimal tested doses were determined during a previous open‐label titration phase (S90049 median dose: 60 mg, apomorphine: 5 mg). Primary endpoint was the maximal change versus baseline in UPDRS motor score (ΔUPDRS III) assessed after drug administration following an overnight withdrawal of antiparkinsonian medications. Thirty patients (age: 60 ± 8 years, PD duration: 12 ± 6 years, UPDRS III OFF: 37 ± 15) participated. S90049 wassuperior to placebo on ΔUPDRS III (−13 ± 12 versus −7 ± 9 respectively; estimated difference −5.2, 95% Confidence Interval (CI)[−10.4;0.05],P= 0.05). This was also true for secondary outcomes: number of patients switching from OFF to ON (17 on S90049 vs. 8 on placebo,P= 0.03), time to turn ON (P= 0.013) and duration of the ON phase (P= 0.03). In the 17 patients who switched ON on S90049, ΔUPDRS III was similar on S90049 (−21.2 ± 10.1) and apomorphine (−23.6 ± 14.1) (estimated difference: 4.0 95% CI [−2.9;10.9]). S90049 was well tolerated: no serious or unexpected adverse event occurred. A single dose of up to 60 mg of S90049 given sublingually was superior to placebo in improving UPDRS III and aborting a practical OFF in patients with advanced PD. Testing greater doses might improve response rate. © 2009 Movement Disorder Society
Plasma α‐synuclein in patients with Parkinson's disease with and without treatment
Authors: Duran Raquel , Barrero Francisco J. , Morales Blas , Luna Juan D. , Ramirez Manuel , Vives Francisco 
Published: January 2010

AbstractAlpha‐synuclein (α‐syn) is an intracellular protein with a high tendency to aggregation. It is the major component of Lewy bodies and may play a key role in the pathogenesis of Parkinson's disease (PD). α‐Syn is also released by neurons and can be detected in biological fluids, such as plasma. The purpose of this study was to determine whether plasma α‐syn concentrations are elevated in newly diagnosed PD patients before treatment (nontreated PD group, ntPD; n = 53) and to compare them with concentrations in PD patients with at least 1 year of specific treatment (tPD; n = 42) and in healthy controls (n = 60). Plasma α‐syn concentrations in the ntPD and tPD groups were similar and significantly higher than in healthy controls. In conclusion, α‐syn was elevated early in the development of PD and specific PD treatment did not change plasma α‐syn levels. © 2010 Movement Disorder Society
Muscular pain in Parkinson's disease and nociceptive processing assessed with CO2 laser‐evoked potentials
Authors: Tinazzi Michele , Recchia Serena , Simonetto Sara , Tamburin Stefano , Defazio Giovanni , Fiaschi Antonio , Moretto Giuseppe , Valeriani Massimiliano 
Published: January 2010

AbstractMuscular pain is the most frequent kind of nondystonic pain associated with Parkinson's disease (PD). It might be related not only to peripheral factors but also to an abnormal nociceptive input processing in the central nervous system. To test this hypothesis, we recorded CO2 laser‐evoked potentials (LEPs) in response to shoulder stimulation (skin over deltoid muscle) in 11 hemiparkinsonian PD patients complaining of muscular pain in the shoulder (ipsilateral to motor symptoms) and compared the results with those obtained in 12 pain‐free PD patients with hemiparkinson and in 11 normal subjects. N2/P2 LEP, which is thought to originate from the cingulate cortex and insula, was significantly lower in amplitude in both groups of PD patients than in controls, regardless of the clinically affected body side. In both groups of PD patients, no significant correlation was observed between the severity of motor symptoms and N2/P2 amplitude abnormalities. In PD patients with muscular pain, the N2/P2 amplitude obtained following stimulation of the painful shoulder was significantly reduced compared with that obtained in response to nonpainful shoulder stimulation and compared with the values obtained in pain‐free PD patients. No significant correlation was observed between the intensity of muscular pain and N2/P2 amplitude abnormalities in this group of PD patients. These results suggest abnormal nociceptive input processing in PD, which appears to be independent of clinical expression of parkinsonian motor signs. These alterations are more evident in the presence of muscular pain. © 2010 Movement Disorder Society
Artistic profession: A potential risk factor for dopamine dysregulation syndrome in Parkinson's disease?
Authors: Schwingenschuh Petra , Katschnig Petra , Saurugg Ronald , Ott Erwin , Bhatia Kailash P. 
Published: January 2010

AbstractA small proportion of patients with Parkinson's disease (PD) develop a dopamine dysregulation syndrome (DDS). Management of such patients can be difficult; hence, early identification and careful monitoring of at‐risk individuals are important. Based on four illustrative cases, we wish to draw attention to the risk of developing DDS in PD patients engaged in a creative and artistic profession, who compulsively abuse dopaminergic drugs to maintain or enhance their artistic creativity. Balancing the drug requirement for treating motor symptoms on one hand and improving creativity on the other hand has to be carefully evaluated and early neuropsychiatric intervention may be necessary. Apart from the known risk factors—young age at PD onset, male gender, heavy alcohol consumption, illegal drug use, and history of affective disorder—engagement in a creative or artistic profession may be an additional risk factor for developing DDS. © 2010 Movement Disorder Society
An exploration of the burden experienced by spousal caregivers of individuals with Parkinson's disease
Authors: Roland Kaitlyn P. , Jenkins Mary E. , Johnson Andrew M. 
Published: January 2010

AbstractAlthough previous research has attempted to identify the needs of caregivers for individuals with Parkinson's disease (PD), most has focused on the demands associated with the physical needs of the patient, and not on “mental burden.” This study used the repertory grid method to capture the full range of caregivers' subjective experience, quantify their perceptions, and to acquire information that might be useful in directing remediation attempts. Within this sample, caregivers reported far greater burden from “mental stress” (e.g., worrying about individual's safety) than from “physical stress” (e.g., lifting individual into bed). Specifically, caregivers were primarily concerned about spousal safety, as this requires continuous vigilance and constant worry. Caregivers also reported experiencing “little deaths” as the disease progresses, related to a loss of independence for the couple, and the steady diminishment of social networks. Increasing attention on the mental burden experienced by spousal caregivers promises to increase quality of care, and quality of life for individuals with PD, by improving quality of life for the caregiver. © 2010 Movement Disorder Society
B cell depletion therapy for new‐onset opsoclonus‐myoclonus
Authors: Pranzatelli Michael R. , Tate Elizabeth D. , Swan Jennifer A. , Travelstead Anna L. , Colliver Jerry A. , Verhulst Steven J. , Crosley Carl J. , Graf William D. , Joseph Suja A. , Kelfer Howard M. , Raju G. Praveen 
Published: January 2010

AbstractTwelve immunotherapy‐naïve children with opsoclonus‐myoclonus syndrome and CSF B cell expansion received rituximab, adrenocorticotropic hormone (ACTH), and IVIg. Motor severity lessened 73% by 6 mo and 81% at 1 yr (P < 0.0001). Opsoclonus and action myoclonus disappeared rapidly, whereas gait ataxia and some other motor components improved more slowly. ACTH dose was tapered by 87%. Reduction in total CSF B cells was profound at 6 mo (‐93%). By study end, peripheral B cells returned to 53% of baseline and serum IgM levels to 63%. Overall clinical response trailed peripheral B cell and IgM depletion, but improvement continued after their levels recovered. All but one non‐ambulatory subject became ambulatory without additional chemotherapy; two relapsed and remitted; four had rituximab‐related or possibly related adverse events; and two had low‐titer human anti‐chimeric antibody. Combination of rituximab with conventional agents as initial therapy was effective and safe. A controlled trial with long‐term safety monitoring is indicated. © 2009 Movement Disorder Society
Fibrin glue mitigates the learning curve of microneurosurgical repair
Authors: Whitlock Elizabeth L. , Kasukurthi Rahul , Yan Ying , Tung Thomas H. , Hunter Daniel A. , Mackinnon Susan E. 
Published: January 2010

AbstractMicroneurosurgical technique has a steep learning curve. An alternative to microepineurial suture repair of peripheral nerves that circumvents this learning curve would be ideal. We investigated the effect of surgeon experience on suture versus fibrin glue coaptations in a mouse sciatic nerve graft model. Sixty‐four mice received sciatic nerve grafts with either suture or fibrin glue repair by either a naïve surgeon (medical student) or a surgeon with extensive microsurgical experience. Grafts underwent quantitative histomorphometry at 3 weeks postoperatively. Suture repairs performed by the naïve surgeon demonstrated significantly poorer distal regeneration than all other repairs. Histomorphometric parameters of suture and glue repairs performed by the experienced surgeon were not significantly different from the glue coaptation by the naïve surgeon. Fibrin glue may be considered as an alternative to microepineurial suture repair, particularly in the setting of relative surgeon inexperience with microsurgical technique. © 2010 Wiley‐Liss, Inc. Microsurgery 2010.
A compact U‐shaped defected ground structure microstrip low‐pass filter with wideband rejection
Authors: Deng Kuan , Feng Wenjie , Che Wenquan 
Published: January 2010

AbstractA compact triple U‐shaped slots etched on the microstrip ground are used to implement a novel low‐pass filter.A rectangular open stub and a radius stub are used to produce transmission zeros and thus result in wide stopband. Good low‐pass performance and wide stopband characteristics can be achieved by this new structure. One prototype is fabricated to demonstrate the validity of the design strategies. The simulated and measured results indicate that the insertion loss is less than 0.25 dB and the return loss is less than −16.7 dB in the whole passband. In addition, significant improvement on rejection band can be observed; the stopband bandwidth better than −25 dB is about 105% (from 2.6 to 8.4 GHz). © 2010 Wiley Periodicals, Inc. Microwave Opt Technol Lett 52: 497–499, 2010; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/mop.24960
Photonic generation of microwave signals by exploiting fiber birefringence effect in single‐longitudinal‐mode distributed Bragg reflector fiber lazer
Authors: Zhang Hao , Liu Bo , Sun Jing , Luo Jianhua , Wang Shuangxia , Jia Chenglai , Ma Xiurong 
Published: January 2010

AbstractA novel all‐optical microwave generation technique based on fiber birefringence effect in single‐longitudinal‐mode (SLM) distributed Bragg reflector (DBR) fiber lazer is presented. Owing to the birefringence‐induced mode splitting, the proposed lazer could provide a microwave signal at ∼1.72 GHz with a 3 dB bandwidth of ∼30 kHz. Moreover, another microwave signal at 10.96 GHz could also be generated as transverse pressure was applied onto the proposed lazer. Similar phenomenon was observed when another DBR lazer constructed with Er/Yb co‐doped fiber was used, and a microwave signal at 11.47 GHz with ∼33 kHz linewidth have also been achieved. © 2010 Wiley Periodicals, Inc. Microwave Opt Technol Lett 52: 535–540, 2010; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/mop.24961
Multilevel fast multipole algorithm enhanced by GPU parallel technique for electromagnetic scattering problems
Authors: Xu Kan , Ding Da Zhi , Fan Zheng Hong , Chen Ru Shan 
Published: January 2010

AbstractAlong with the development of graphics processing Units (GPUS) in floating point operations and programmability, GPU has increasingly become an attractive alternative to the central processing unit (CPU) for some of compute‐intensive and parallel tasks.In this article, the multilevel fast multipole algorithm (MLFMA) combined with graphics hardware acceleration technique is applied to analyze electromagnetic scattering from complex target. Although it is possible to perform scattering simulation of electrically large targets on a personal computer (PC) through the MLFMA, a large CPU time is required for the execution of aggregation, translation, and deaggregation operations. Thus GPU computing technique is used for the parallel processing of MLFMA and a significant speedup of matrix vector product (MVP) can be observed. Following the programming model of compute unified device architecture (CUDA), several kernel functions characterized by the single instruction multiple data (SIMD) mode are abstracted from components of the MLFMA and executed by multiple processors of the GPU. Numerical results demonstrate the efficiency of GPU accelerating technique for the MLFMA. © 2010 Wiley Periodicals, Inc. Microwave Opt Technol Lett 52: 502–507, 2010; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/mop.24963
Miniaturized band‐stop filter based on multilayer‐technique and new coupled octagonal defected ground structure with interdigital capacitor
Authors: Boutejdar A. , Abdel‐Rahman A. , Batmanov A. , Burte P. , Omar A. 
Published: January 2010

AbstractIn this article, we proposed a new compact defected ground structure (DGS) band‐stop filter with broad passband and low insertion loss in the stop‐band. The philosophy of the structure behind this new microstrip band‐stop filter is simple as it is composed of a pair of octagonal DGS‐slots and an open‐stub as compensated microstrip capacitance. The filter will be realized through direct electromagnetic coupling and slow wave effect methods. With this configuration, the BSF with higher compactness, broad passband and sharp transition characteristics was realized. The design formulas are derived by using an equivalent‐circuit model of a parallel L‐C resonator. Finally, an interdigital‐capacitor has been designed and included in the DGS‐ring‐element. Better compactness of the structure and symmetry of the frequency response have been achieved as well as two reflection zeros closed to the stopband have been obtained. Thus, a selectivity of the proposed filter has been improved. To validate the feasibility of the proposed design method, both band‐stop filters are designed, fabricated, and measured. The experimental results agree well with the simulation results. © 2010 Wiley Periodicals, Inc. Microwave Opt Technol Lett 52: 510–514, 2010; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/mop.24967
A compact wideband bandpass filter using modified NB‐SRRs with wide upper bandstop
Authors: Chaimool Sarawuth , Akkaraekthalin Prayoot 
Published: January 2010

AbstractA new type of compact wideband bandpass filter using modified non‐bianisotropic split‐ring resonators is proposed to have wideband performance and suppress spurious responses. With the proposed resonators, size reduction of ∼15% and 20% when comparing single outer and inner constituent rings has been obtained. Embedded‐slot‐loaded resonators are placed at both input and output feed lines for extra stopband rejection modes to suppress spurious frequencies with attenuation losses over than 15 dB for a frequency range up to 3.1 f0 without affecting the operation band. In addition, due to the zero‐degree feed structure, the appearance of two transmission zeros, thereby suppressing the second harmonic response has been obtained. This filter has not been only compact size but also a wider upper stopband caused by slot‐loaded resonator bandstop characteristics. Good agreement is obtained between simulations and measurements. © 2010 Wiley Periodicals, Inc. Microwave Opt Technol Lett 52: 551–553, 2010; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/mop.24968
Fully adaptable band‐stop filter using varactor diodes
Authors: Musoll‐Anguiano Carles , Llamas‐Garro Ignacio , Brito‐Brito Zabdiel , Pradell Lluis , Corona‐Chavez Alonso 
Published: January 2010

AbstractIn this article a reconfigurable band‐stop filter able to reconfigure center frequency, bandwidth, and selectivity for fine tuning applications is demonstrated, device topology discussion and implementation details are given, and followed by discussion on simulations and measurements.The reconfigurable filter topology has four poles and a quasi‐elliptic band‐stop filter response. The device is tuned by varactor diodes placed at different locations on the filter; varactors are voltage controlled in pairs due to filter symmetry for center frequency and bandwidth control. An additional varactor is placed on a crossing line to move a pair of transmission zeros, closer or farther to the filter center frequency, which tunes filter selectivity. Simulations show a tuneable center frequency range from 1.42 to 1.48 GHz, a tuneable fractional bandwidth range from 9.46 to 12.96%, and a tuneable selectivity range from 0.53 to 0.65 dB/MHz. Measurements show a tuneable center frequency range from 1.37 to 1.43 GHz, a tuneable fractional bandwidth range from 11.31 to 15.93%, and a selectivity tuning range from 0.37 to 0.40 dB/MHz. Simulations and measurements are in good agreement. © 2010 Wiley Periodicals, Inc. Microwave Opt Technol Lett 52: 554–558, 2010; Published online in Wiley InterScience (www.interscience. wiley.com). DOI 10.1002/mop.24969
A novel tri‐band filter using stub‐loaded open loop ring resonators
Authors: Lai Xin , Wu Bian , Su Tao , Liang Chang‐Hong 
Published: January 2010

AbstractIn this article, a novel type of compact tri‐band filter using stub‐loaded open‐loop ring resonators (OLRRs) is presented.With the open stub loaded, the resonant frequency of the OLRR can be tuned by the tapped location and length of the loaded stub, which makes the OLRR more compact. Making use of the microstrip open‐ended feed line, proper external couplings are provided to each passband by magnetic coupling. A tri‐band filter centered at 2.0 GHz, 3.2 GHz, and 4.3 GHz is designed, fabricated and measured. Predicted results are verified by the experiments. © 2010 Wiley Periodicals, Inc. Microwave Opt Technol Lett 52: 523–526, 2010; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/mop.24971
Iterative design of moth‐eye antireflective surfaces at millimeter wave frequencies
Authors: Mirotznik Mark S. , Good Brandon , Ransom Paul , Wikner David , Mait Joseph N. 
Published: January 2010

AbstractA method for synthesizing broadband antireflective (AR) surfaces at millimeter wave frequencies is demonstrated. AR surfaces were formed by machining a multilayer subwavelength structures into nonabsorptive dielectrics. This created low‐reflected energies (<−25 dB) over large bandwidths and incidence angles. Experimental results are provided demonstrating the validity of the method. © 2010 Wiley Periodicals, Inc. Microwave Opt Technol Lett 52: 561–568, 2010; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/mop.24973
Efficiency enhancement of the Doherty amplifier for 3.5 GHz WiMAX application using class‐F circuitry
Authors: Park Jun‐Chul , Kim Dongsu , Yoo Chan‐Sei , Lee Woo Sung , Yook Jong‐Gwan , Hahn Cheol Koo 
Published: January 2010

AbstractThis article presents a high‐power and high‐efficiency saturated Doherty amplifier using a GaN high electron mobility transistor for 3.5 GHz Worldwide Interoperability for Microwave Access application.The saturated Doherty amplifier is a Doherty amplifier based on class‐F amplifiers, resulting in higher efficiency than a conventional Doherty amplifier. The distributed‐type harmonic control circuit is located between a power transistor and an output matching circuit. From the measured results for a continuous wave of 3.5 GHz, the saturated Doherty amplifier attains a high P3dB of 45 dBm and a power gain of about 8.8 dB. Also, the proposed Doherty amplifier provides a high power‐added‐efficiency (PAE) of 37.7% and a drain efficiency of 42.7% at 6‐dB back‐off output power region from P3dB, which are 8.7% and 5.7% higher than those of the conventional Doherty amplifier. Compared to the single class‐AB amplifier, we obtain 17.7% and 19.7% improvement of PAE and drain efficiency, respectively. © 2010 Wiley Periodicals, Inc. Microwave Opt Technol Lett 52: 570–573, 2010; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/mop.24977
Pattern reconfiguration of microstrip antenna using flip‐chip mounted packaged MEMS
Authors: Raj R. , Poussot B. , Laheurte J.‐M. , Vendier O. 
Published: January 2010

AbstractThis work describes the design of a radiation pattern reconfigurable microstrip antenna electrically controlled by packaged Radio frequency micro‐electro‐mechanical system (RF MEMS). The antenna operates at 12.24 GHz with good return loss characteristics and a ∼7.5 dBi gain at ±30° scan angles from broadside direction in the H‐plane. The integration of packaged RF MEMS and associated bias networks is also explained. © 2010 Wiley Periodicals, Inc. Microwave Opt Technol Lett 52: 574–577, 2010; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/mop.24978