bluuebunny/crossref_metadata_2025_split huggingface dataset:
COMMD10 Regulates Endosomal Recycling of Epithelial Sodium Channel (ENaC)
Authors: Rasulov Sahib R. , McDonald Fiona J. 
Published: June 2024

SummaryThe epithelial sodium channel (ENaC) plays an essential role in the regulation of sodium transport in distal nephron. ENaC cell surface population of renal principal cells is tightly regulated by hormones such as aldosterone and vasopressin through protein trafficking pathways that translocate ENaC to and from the cell surface. Internalized ENaC from the plasma membrane follows the degradative pathway promoted by ubiquitin fusion or the recycling pathway after deubiquitination and sorting on early endosomes. The mechanism by which ENaC is recycled back to the plasma membrane through regulated recycling is less known. Here, we show that regulated recycling of ENaC is strictly dependent on COMMD10 and localization pattern of COMMD10 on Rab5, −7, and −11 vesicles is similar to that of WASH and Arp2/3. Furthermore, here we report that COMMD1 and −10 protein levels are regulated by aldosterone and calcium. This study proposes that for regulated recycling of ENaC, conventional endosomal sorting and recycling complexes such as CCC complex are recruited.HighlightsCOMMD10 alters ENaC cell surface population through the regulated recycling pathway. COMMD10 localizes on Rab5-, Rab7-, and Rab11-positive endosomes in a similar pattern as endosomal actin polymerization complexes WASH and Arp2/3. Aldosterone downregulates COMMD1 and −10 protein levels while calcium upregulates COMMD10 protein level.Graphical Abstract
Laser-driven ion and electron acceleration from near-critical density gas targets: Towards high-repetition rate operation in the 1 PW, sub-100 fs laser interaction regime
Authors: Ospina-Bohórquez V. , Salgado-López C. , Ehret M. , Malko S. , Salvadori M. , Pisarczyk T. , Chodukowski T. , Rusiniak Z. , Krupka M. , Guillon P. , Lendrin M. , Pérez-Callejo G. , Vlachos C. , Hannachi F. , Tarisien M. , Consoli F. , Verona C. , Prestopino G. , Dostal J. , Dudzak R. , Henares J. L. , Apiñaniz J. I. , De Luis D. , Debayle A. , Caron J. , Ceccotti T. , Hernández-Martín R. , Hernández-Toro J. , Huault M. , Martín-López A. , Méndez C. , Nguyen-Bui T.-H. , Perez-Hernández J. A. , Vaisseau X. , Varela O. , Volpe L. , Gremillet L. , Santos J. J. 
Published: June 2024

Ion acceleration from gaseous targets driven by relativistic-intensity lasers was demonstrated as early as the late 1990s, yet most of the experiments conducted to date have involved picosecond-duration, Nd:glass lasers operating at low repetition rate. Here, we present measurements on the interaction of ultraintense (≈1020Wcm−2, 1 PW), ultrashort (≈70fs) Ti:Sa laser pulses with near-critical (≈1020cm−3) helium gas jets, a debris-free targetry with the potential for future compatibility with high (≈1 Hz) repetition rate operation. We provide evidence of α particles being forward accelerated up to ≈2.7−MeV energy with a total flux of ≈1011sr−1 as integrated over >0.1−MeV energies and detected within a 0.5−mrad solid angle. We also report on on-axis emission of relativistic electrons with an exponentially decaying spectrum characterized by a ≈10−MeV slope, i.e., five times larger than the standard ponderomotive scaling. The total charge of these electrons with energy above 2 MeV is estimated to be of ≈1nC, corresponding to ≈0.1% of the laser drive energy. In addition, we observe the formation of a plasma channel, extending longitudinally across the gas density maximum and expanding radially with time. These results are well captured by large-scale particle-in-cell simulations, which reveal that the detected fast ions most likely originate from reflection off the rapidly expanding channel walls. The latter process is predicted to yield ion energies in the MeV range, which compare well with the measurements. Finally, direct laser acceleration is shown to be the dominant mechanism behind the observed electron energization.

Published by the American Physical Society
2024
Breaking stereotypes: investigating the dynamics of male celebrity endorsements in China’s cosmetic industry
Authors: Yu Kaidong 
Published: June 2024

PurposeMale celebrities are increasingly being chosen to endorse female cosmetic brands by marketing managers, yet this practice has not received sufficient scholarly attention. This study aims to explore the dynamics of male celebrities endorsing cosmetic brands.Design/methodology/approachThe study employs the netnography approach to collect data from an online community.FindingsThe study contributes to the marketing literature by providing a conceptual framework of male celebrities endorsing cosmetic brands, highlighting the key attributes that contribute to the effectiveness of these endorsements, the evolution of relationships between fans, celebrities and brands, the features of this dynamic relationship and the influence of male celebrity endorsements on fans’ purchase decisions.Originality/valueThis research sheds light on an emerging trend in the marketing industry and provides valuable managerial insights for marketers seeking to effectively use male celebrity endorsements to promote female cosmetic brands.
Is it your neighbors or the neighborhood making you sick? Lifestyle, built environment, and COVID-19 transmission
Authors: Turnbull Geoffrey K. , Salvino Robert , Njoroge Phillip K. , Batabyal Sourav 
Published: June 2024

Purpose
This paper examines the early pandemic experience in a large metropolitan area to differentiate the roles of the lifestyle and built environment factors associated with differing case rates across neighborhoods.

Design/methodology/approach
This paper develops a simple empirical methodology for sorting out the separate effects of lifestyle and the built environment factors along with their interactive effects when individuals’ behaviors not only reflect their observable characteristics but also are influenced by the physical environments in which they live and work, indirect connections implied by the early insights of Jacobs (1961) and more recently Hawley and Turnbull (2019).

Findings
The results demonstrate that lifestyle factors tied to employment show the strongest association with COVID-19 cases. Other lifestyle choices, built environment features, and demographic attributes such as household size, principal cities, highway connectivity, and population density also affect COVID-19 transmission at the onset of the disease outbreak. The analysis reveals a surprising spatial pattern; employment-related lifestyle factors on case rates in outlying neighborhoods are stronger than in neighborhoods within primary cities after accounting for various built environment factors.

Originality/value
This research addresses important questions and the perplexing outcomes related to lifestyle and the built environment’s multi-faceted role in spreading COVID-19. In addition, this study represents a pioneering effort in disentangling the pure lifestyle effect on virus transmission after eliminating potentially confounding impacts of built environment factors on household behavior that in turn influence virus transmission.
The role of digital payments in overspending behavior: a mental accounting perspective
Authors: Shah Mohay Ud Din , Khan Ikram Ullah , Khan Naimat U. 
Published: June 2024

PurposeThe paper examines how individuals can be susceptible to payment biases in the context of digital payment behavior by utilizing the concept of mental accounting. Furthermore, the paper investigates the moderating effects of Digital Financial Literacy (DFL) on the relationship between payment methods and spending behavior.Design/methodology/approachThe study employs a survey-based approach to collect data from 503 individuals who use digital payment methods, utilizing purposive sampling from Pakistan. The collected data is analyzed using Smart-PLS 4 software to assess the direct impact of payment methods on spending behavior and the moderating influence of DFL.FindingsThe research findings demonstrate that both digital and cash payments significantly affect spending behavior. However, digital payments have a more substantial impact on spending behavior compared to cash payments. The findings also show that DFL significantly positively moderates individual spending. The study validates the mental accounting perspective by evaluating the direct impact of payment methods on consumers' spending behavior.Practical implicationsThe findings have practical implications for policymakers, financial institutions, and educators. Policymakers can leverage the insights to design effective strategies that promote responsible spending behavior and enhance the adoption of digital payment methods. Financial institutions can design user-friendly platforms that cater to users' spending preferences, while educators can develop programs to enhance Digital Financial Literacy (DFL) among the public.Social implicationsThis study’s social implications lie in its potential to contribute to individuals' financial well-being by promoting responsible spending through digital payment methods. Enhanced financial literacy and informed spending decisions can lead to better financial management and ultimately contribute to societal financial stability.Originality/valueThe study enriches the understanding of mental accounting, shedding light on how overspending behavior can manifest through digital payment channels. In addition, this research practically provides valuable insights into enhancing the adoption and financial literacy of digital payments among the public.
Advances in hub location problems: a literature review and research agenda
Authors: Sharma Ankit , Jakhar Suresh Kumar , Vlachos Ilias , Kumar Satish 
Published: June 2024

PurposeOver the past two decades, the hub location domain has witnessed remarkable growth, yet no prior study reviewed and synthesised problem formulation and solution methodologies to address real-life challenges.Design/methodology/approachThe current study conducts a comprehensive bibliometric literature review to develop a thematic framework that describes and presents hub location problems. The work employs cluster, bibliometric, and social network analyses to delve into the essential themes.FindingsKey themes include cooperation, coopetition, sustainability, reshoring, and dynamic demand, contributing to the complex challenges in today’s hub location problems. As the first work in this field, the study serves as a valuable single-source reference, providing scholars and industry practitioners with key insights into the evolution of hub location research, prominent research clusters, influential authors, leading countries, and crucial keywords.Research limitations/implicationsFindings have significant implications since they highlight the current state of hub location research and set the stage for future endeavours. Specifically, by identifying prominent research clusters, scholars can explore promising directions to push the boundaries of knowledge in this area.Originality/valueThis work is a valuable resource for scholars in this domain and offers practical insights for industry practitioners seeking to understand the hub location problems. Overall, the study’s holistic approach provides a solid foundation for advancing future research work in the hub location field.
Influencing factors and action paths for public crisis governance performance improvement in digital twin cities
Authors: Shan Shaonan , Song Yipeng , Wang Chunjuan , Ji Wenyan 
Published: June 2024

PurposeThrough the study, we identified four effective paths to improve governance performance and also found the key direction for future research on digital twin urban implementation of public crisis governance, i.e. how to find a balance between the cost and the effectiveness of governance.Design/methodology/approachA total of 22 urban public emergencies were selected based on key influencing factors, and four action paths to improve the performance of public crisis governance in digital twin cities were obtained using a fuzzy set qualitative comparative analysis model.FindingsThis paper identified digital twin technologies in urban public crisis governance, analyzed the key factors of public crisis governance in the digital twin city and proposed a path of action to improve the performance of public crisis governance in digital twin cities.Originality/valueThis study focuses on the influencing factors of public crisis governance in digital twin cities and the action paths to promote improved governance performance.
Political incentives and analyst bias: Evidence from China
Authors: Pittman Jeffrey , Yang Zhifeng , Yu Sijia , Zhu Haoran 
Published: June 2024

AbstractThis study extends extant research on the determinants of financial analyst bias by examining the role that political incentives play. Using a series of scheduled provincial political events in China, we document that analysts are significantly more likely to issue favorable recommendations or revise their recommendations upward during political event periods, and the effect of political events on optimism is larger for analysts employed by brokerage firms affiliated with politicians. Cross‐sectional evidence suggests that the impact of political events on analyst optimism is concentrated in those provinces where capital market development is a more important performance indicator for politicians or where the incumbent politicians face a pending promotion. Stock return analyses reveal that favorable recommendations issued during political event periods are significantly less profitable in the long run and are less credible according to investor perceptions. Reinforcing our main evidence, we also find that financial analysts are more likely to issue optimistic earnings forecasts during political event periods. Collectively, our results imply that political incentives distort analyst opinions and political‐economic factors affect the corporate information environment in China.
Role of calcineurin in regulating renal potassium (K+) excretion: Mechanisms of calcineurin inhibitor‐induced hyperkalemia
Authors: Duan Xin‐Peng , Zhang Cheng‐Biao , Wang Wen‐Hui , Lin Dao‐Hong 
Published: June 2024

AbstractCalcineurin, protein phosphatase 2B (PP2B) or protein phosphatase 3 (PP3), is a calcium‐dependent serine/threonine protein phosphatase. Calcineurin is widely expressed in the kidney and regulates renal Na+ and K+ transport. In the thick ascending limb, calcineurin plays a role in inhibiting NKCC2 function by promoting the dephosphorylation of the cotransporter and an intracellular sorting receptor, called sorting‐related‐receptor‐with‐A‐type repeats (SORLA), is involved in modulating the effect of calcineurin on NKCC2. Calcineurin also participates in regulating thiazide‐sensitive NaCl‐cotransporter (NCC) in the distal convoluted tubule. The mechanisms by which calcineurin regulates NCC include directly dephosphorylation of NCC, regulating Kelch‐like‐3/CUL3 E3 ubiquitin–ligase complex, which is responsible for WNK (with‐no‐lysin‐kinases) ubiquitination, and inhibiting Kir4.1/Kir5.1, which determines NCC expression/activity. Finally, calcineurin is also involved in regulating ROMK (Kir1.1) channels in the cortical collecting duct and Cyp11 2 expression in adrenal zona glomerulosa. In summary, calcineurin is involved in the regulation of NKCC2, NCC, and inwardly rectifying K+ channels in the kidney, and it also plays a role in modulating aldosterone synthesis in adrenal gland, which regulates epithelial‐Na+‐channel expression/activity. Thus, application of calcineurin inhibitors (CNIs) is expected to abrupt calcineurin‐mediated regulation of transepithelial Na+ and K+ transport in the kidney. Consequently, CNIs cause hypertension, compromise renal K+ excretion, and induce hyperkalemia.
Internet videoconferencing delivered cognitive behaviour therapy for generalized anxiety disorder: A randomized controlled trial
Authors: Trenoska Basile Vesna , Newton‐John Toby , McDonald Sarah , Wootton Bethany M. 
Published: June 2024

AbstractObjectiveGeneralized anxiety disorder (GAD) is a chronic mental health condition that results in significant individual and societal burden. Cognitive‐behaviour therapy (CBT) therapy is an effective treatment for GAD, however, many individuals experience logistical barriers when accessing evidence‐based care. Remote treatments may help to reduce these barriers, however, currently, there are few studies examining the efficacy of high‐intensity remote methods for GAD treatment. The current study aims to examine the efficacy of CBT delivered via videoconferencing (VCBT) for GAD using a randomized controlled trial design comparing an immediate treatment group to a waitlist control.MethodSeventy‐eight adults (M
age = 36.92; SD = 12.92; 84.4% female) with GAD were enrolled in the study.ResultsThose in the treatment group demonstrated a statistically significant reduction in GAD symptoms from pre‐treatment to post‐treatment (d = 1.03) and pre‐treatment to 3‐month follow‐up (d = 1.50). Large between‐group effect sizes were also observed at post‐treatment (d = .80). Twenty‐five participants (64.10%) in the VCBT group no longer met diagnostic criteria for GAD at post‐treatment, and 26/39 (66.67%) no longer met criteria at 3‐month follow‐up. Ninety‐six per cent of participants were satisfied with the treatment.ConclusionThe results contribute towards advancing our knowledge on the efficacy and acceptability of VCBT for patients with GAD.
Preservice teachers' learning by design through space construction in the metaverse
Authors: Lee Sangmin‐Michelle , Kim Sung‐Yeon 
Published: June 2024

AbstractTeachers who know what, how and why to teach are essential for successful student learning. However, many preservice teachers (PSTs) lack teaching experience and the ability to integrate theory and practice. To help bridge this gap, this study employed a learning‐by‐design project approach in which 22 Korean PSTs developed lesson plans for middle school English classes, constructed virtual classrooms in the metaverse based on their English lesson plans, and conducted microteaching in the virtual classrooms. The study used a qualitative research method and focused on an emic perspective with multiple data sets, including the PSTs' reflection papers and post‐interviews as primary data, and their lesson plans, virtual classrooms and recordings of microteaching as secondary data. The results showed that the project supported learning by design, and that it also helped PSTs understand learners and learning, redefine the teacher's role as a designer and facilitator, connect theories to practice and improve their teaching skills. The findings can be used as a reference for future teacher training.
Practitioner notesWhat is already known about this topic

Teachers' content, pedagogical and technological knowledge and skills are essential attributes for effective performance.
Preservice teachers (PSTs) have difficulty transferring their knowledge to real classrooms because their knowledge often focuses on the ‘know‐what’ of teaching, but not on the ‘know‐how’.
Microteaching in virtual environments helps PSTs connect knowledge and practice and prepare for real classroom situations.
What this paper adds

The study applied a learning‐by‐design approach to preservice teachers' microteaching to help them connect their pedagogical knowledge to classroom practice.
The study focused on describing how the PSTs' virtual classroom design influenced the way they planned and implemented their microteaching.
Implications for practice and/or policy

Teacher educators can incorporate the design‐based approach into their teacher training modules to help teachers understand learner needs when planning and implementing English lessons.
Teachers can develop technological literacy and positive attitudes about using technology in their classrooms.
Unalienated labor as cooperative self‐determination: Aristotle and Marx
Authors: Scott Kyle 
Published: June 2024

AbstractIn this paper, I offer an original interpretation of Marx's conception of unalienated labor, which I frame as a response to Aristotle's view of work, or technē. Both Aristotle and Marx share a particular conception of freedom as “normative self‐determination,” according to which an activity is free insofar as it does not depend for its value on externally valuable things. For instance, when my activity is a mere means for satisfying some need separate from it, it comes to depend for its value on the externally valuable effect—the “needs‐meeting”—it achieves. Or, when my activity is only causally—but not normatively—enabled by the cooperative contributions of others, it comes to depend for its value on those externally valuable contributions. On Aristotle's view, work is unleisurely (ascholos) and servile (doulos) because it is normatively dependent in both of these ways. For Marx, by contrast, work possesses the capacity to “internalize” these external determinants of its value. Unalienated work does this, first, by satisfying “internal” needs, or needs whose satisfaction does not constitute a normatively external effect of the work that satisfies them. The satisfaction of internal needs is valuable because of the manner or way in which they are satisfied. Second, unalienated work would not only be causally, but also normatively, enabled by the contributions of others, in that those contributions would help to make it the distinctively valuable act that it is. Unalienated work would be valuable because, and not despite, its cooperative character. In both of these respects, then, cooperation is essential to make work fully free.
Risk factors for advanced colorectal neoplasia and colorectal cancer detected at surveillance: a nationwide study in the modern era
Authors: Smits Lisanne J H , Siebers Albert G , Lissenberg‐Witte Birgit I , Lansdorp‐Vogelaar Iris , van Kouwen Mariette C A , Tuynman Jurriaan B , van Grieken Nicole C T , Nagtegaal Iris D 
Published: June 2024

AimRecommendations for surveillance after colonoscopy are based on risk factors for metachronous advanced colorectal neoplasia (AN) and colorectal cancer (CRC). The value of these risk factors remains unclear in populations enriched by individuals with a positive faecal immunochemical test and were investigated in a modern setting.Methods and ResultsThis population‐based cohort study included all individuals in the Netherlands of ≥55 years old with a first adenoma diagnosis in 2015. A total of 22,471 patients were included. Data were retrieved from the Dutch Nationwide Pathology Databank (Palga). Primary outcomes were metachronous AN and CRC. Patient and polyp characteristics were evaluated by multivariable Cox regression analyses. During follow‐up, 2416 (10.8%) patients were diagnosed with AN, of which 557 (2.5% from the total population) were CRC. Adenomas with high‐grade dysplasia (hazard ratio [HR] 1.60, 95% confidence interval [CI] 1.40–1.83), villous histology (HR 1.91, 95% CI 1.59–2.28), size ≥10 mm (HR 1.12, 95% CI 1.02–1.23), proximal location (HR 1.12, 95% CI 1.02–1.23), two or more adenomas (HR 1.28, 95% CI 1.16–1.41), and serrated polyps ≥10 mm (HR 1.67, 95% CI 1.42–1.97) were independent risk factors for metachronous AN. In contrast, only adenomas with high‐grade dysplasia (HR 2.49, 95% CI 1.92–3.24) were an independent risk factor for metachronous CRC.ConclusionsRisk factors for metachronous AN and CRC were identified for populations with access to a faecal immunochemical test (FIT)‐based screening programme. If only risk factors for metachronous CRC are considered, a reduction in criteria for surveillance seems reasonable.