bluuebunny/crossref_metadata_2025_split huggingface dataset:
ChemInform Abstract: Progress in Carbonylative‐Heck Reactions of Aryl Bromides: Catalysis and DFT Studies.
Authors: Wu Xiao‐Feng , Jiao Haijun , Neumann Helfried , Beller Matthias 
Published: July 2011

AbstractCinnamylpalladium/PPh3 is found to be an inexpensive and convenient catalyst system for the coupling of aryl bromides with styrenes in the presence of CO to give chalcones (22 examples).
ChemInform Abstract: Organic Reaction in Solkane® 365 mfc: Homocoupling Reaction of Terminal Alkynes.
Authors: Kusuda Akihiro , Xu Xiu‐Hua , Wang Xin , Tokunaga Etsuko , Shibata Norio 
Published: July 2011

AbstractSolkane® 365 mfc is proved to be an environmentally benign alternative solvent for the homocoupling reaction of terminal alkynes (I) under air to afford 1,3‐diynes (II) in high yields.
ChemInform Abstract: [3,3]‐Sigmatropic Rearrangement/5‐exo‐dig Cyclization Reactions of Benzyl Alkynyl Ethers: Synthesis of Substituted 2‐Indanones and Indenes.
Authors: Tudjarian Armen A. , Minehan Thomas G. 
Published: July 2011

AbstractAt 60°C, a number of substrates affords indanones like (III).
ChemInform Abstract: Iron—Ligand Coordination in Tandem Radical Cyclizations: Synthesis of Benzo[b]thiophenes by a One‐Pot Reaction of Iron 1,3‐Diketone Complexes with 2‐Thiosalicylic Acids.
Authors: Chan Sharon Lai‐Fung , Low Kam‐Hung , Yang Chen , Cheung Samantha Hui‐Fung , Che Chi‐Ming 
Published: July 2011

AbstractSubstituted hydroxybenzo[b]thiophenes are synthesized by reaction of iron (III) reagents with thiosalicylic acids.
ChemInform Abstract: 4‐Fluoropyrrolidine‐2‐carbonyl Fluorides: Useful Synthons and Their Facile Preparation with 4‐tert‐Butyl‐2,6‐dimethylphenylsulfur Trifluoride.
Authors: Singh Rajendra P. , Umemoto Teruo 
Published: July 2011

AbstractThe fluorides can smoothly be converted into biologically interesting esters, amides, and nitriles.
ChemInform Abstract: Synthesis of New N‐Alkyl(aryl)‐2,4‐diaryl‐1H‐pyrrol‐3‐ols via Aldol Paal—Knorr Reactions.
Authors: Eftekhari‐Sis B. , Akbari A. , Amirabedi M. 
Published: July 2011

AbstractFully substituted pyrrol‐3‐ol derivatives (V) are prepared via aldol reactions of propane‐2‐one with phenylglyoxal followed by Paal—Knorr reaction with amines.
ChemInform Abstract: A Facile Procedure for Synthesis of 3‐[2‐(N,N‐Dialkylamino)ethyl]‐3‐fluorooxindoles by Direct Fluorination of N,N‐Dialkyltryptamines.
Authors: Seki Takayuki , Fujiwara Tomoya , Takeuchi Yoshio 
Published: July 2011

AbstractThe conversion of (I) to (II) is accomplished by means of Selectfluor.
ChemInform Abstract: Iodine‐Catalyzed Conjugate Addition of Indole with α‐Cinnamylideneketones: Formation of β‐(3‐Indolyl)‐α,β‐dihydro‐α‐cinnamylideneketones and Bis(3‐indolyl)methylbenzene.
Authors: Pal Rammohan , Mandal Tapas K. , Mallik Asok K. 
Published: July 2011

AbstractAddition products (III) and (VI) are hitherto unknown compounds and potential intermediates for the synthesis of new indole derivatives.
ChemInform Abstract: Ionic Liquids Containing Carboxyl Acid Moieties Grafted onto Silica: Synthesis and Application as Heterogeneous Catalysts for Cycloaddition Reactions of Epoxide and Carbon Dioxide.
Authors: Han Lina , Choi Hye‐Ji , Choi Soo‐Jin , Liu Binyuan , Park Dae‐Won 
Published: July 2011

AbstractA series of carboxyl‐group‐functionalized imidazolium‐based ionic liquids are synthesized and grafted onto silica gel.
ChemInform Abstract: Novel Synthesis of Highly Functionalized Pyrazolone Systems via Rearrangement of 5‐Phenyl‐1‐oxa‐5,6‐diazaspiro[2.4]heptane‐4,7‐diones.
Authors: Metwally S. A. M. , Mohamed T. A. , Moustafa O. S. , El‐Ossaily Y. A. 
Published: July 2011

AbstractThe products of the reaction of diazaspiro[2.4]heptane‐4,7‐dione derivatives (II) with nucleophilic reagents depend on the type of the diazaspiro compound and/or the nucleophile used.
ChemInform Abstract: Efficient Synthesis of 2,4‐Disubstituted Thiazoles under Grinding.
Authors: Heravi Majid M. , Poormohammad Nargess , Beheshtiha Yahia S. , Baghernejad Bita 
Published: July 2011

AbstractA simple, mild, environmentally friendly, and convenient protocol for the synthesis of the title compounds (III) including an easy work‐up is described.
ChemInform Abstract: Functionalization of the Benzo[c][1,2,5]thiadiazole Scaffold via Mg‐, Zn‐ and Mn‐Intermediates.
Authors: Zimdars Silvia , Langhals Heinz , Knochel Paul 
Published: July 2011

AbstractThe regioselective metallation of benzo[c][1,2,5]thiadiazole (I) and related dibromo derivatives (VIII) and (XI) is investigated with LiCl‐solubilized TMP‐bases to give organometallic intermediates which are prone to undergo Pd‐catalyzed coupling reactions.
ChemInform Abstract: Efficient Copper‐Catalyzed C—S Cross‐Coupling of Heterocyclic Thiols with Aryl Iodides.
Authors: Niu Liang‐Feng , Cai Yan , Liang Chao , Hui Xin‐Ping , Xu Peng‐Fei 
Published: July 2011

AbstractA wide range of heterocyclic thiones or thiols are reacting with the aromatic and aliphatic iodides at the S‐site exclusively to afford the thioethers with high yields.
ChemInform Abstract: The First Application of 4‐Alkoxy‐1,1,1‐trifluoroalk‐3‐en‐2‐ones in a Three‐Component Condensation Protocol for the Synthesis of 3‐Acyl‐4‐aryl‐2‐ (trifluoromethyl)‐2‐hydroxy‐3,4,7,8‐tetrahydro‐2H‐chromen‐5(6H)‐ones.
Authors: Bonacorso Helio G. , Navarini Jussara , Wiethan Carson W. , Bortolotto Guilherme P. , Paim Gisele R. , Cavinatto Susiane , Martins Marcos A. P. , Zanatta Nilo , Caro Miguel S. B. 
Published: July 2011

AbstractAll products are purified by recrystallization and subsequent drying in a desiccator under reduced pressure over phosphorous pentoxide.
ChemInform Abstract: Synthesis of Novel Electron‐Deficient Chromone‐Fused Dienes via Phosphine Catalyzed [4 + 2] Annulation.
Authors: Waldmann Herbert , Bruss Hanna , Dueckert Heiko , Kumar Kamal 
Published: July 2011

AbstractHetero‐Diels—Alder reaction of ketoester (I) with acetylenic esters followed by acid‐ catalyzed ring‐opening of the resulting benzopyrones offers an interesting synthesis of the synthetically important target compounds.
ChemInform Abstract: Iron‐Catalyzed Synthesis of Functionalized 2H‐Chromenes via Intramolecular Alkyne—Carbonyl Metathesis
Authors: Bera Krishnendu , Sarkar Soumen , Biswas Srijit , Maiti Sukhendu , Jana Umasish 
Published: July 2011

Abstracta versatile and environmentally friendly method to prepare a wide range of derivatives
ChemInform Abstract: Eco‐Friendly Synthesis of 1,8‐Dioxo‐octahydroxanthenes Catalyzed by Ionic Liquid in Aqueous Media.
Authors: Fang Dong , Yang Jin‐Ming , Liu Zu‐Liang 
Published: July 2011

Abstract3‐(N,N‐dimethyldodecylammonium)propanesulfonic acid hydrogen sulfate is applied as Broensted acid‐surfactant‐combined catalyst for the one‐pot synthesis of 1,8‐dioxo‐octahydroxanthenes (III).
ChemInform Abstract: A New Three‐Step Domino Knoevenagel—hetero‐Diels—Alder Oxidation Reaction.
Authors: Bryhas Andriy O. , Horak Yuri I. , Ostapiuk Yuri V. , Obushak Mykola D. , Matiychuk Vasyl S. 
Published: July 2011

AbstractReaction of benzaldehydes (I) and the naphthyl analogue (IV) with thiazolidinone (II) is followed by spontaneous oxidation to give condensed heterocycles including a thiopyranium salt system.
ChemInform Abstract: Synthesis, Spectral, Crystal Structure and in vitro Antimicrobial Evaluation of Imidazole/Benzotriazole Substituted Piperidin‐4‐one Derivatives.
Authors: Ramachandran R. , Rani M. , Senthan S. , Jeong Yeon Tae , Kabilan S. 
Published: July 2011

AbstractCompounds (IIIa) and (IIIc) show excellent inhibition activity against B.
ChemInform Abstract: Palladium‐Catalyzed Amination of 2‐Chloro‐1‐azaazulene with 2‐Aminopyridine.
Authors: Oda Mitsunori , Miyawaki Daisuke , Matsumoto Naoko , Kuroda Shigeyasu 
Published: July 2011

AbstractSince compounds (III) and (IV) exhibit a significant change in their absorption and emission spectra in the presence of certain metal cations, they could be potentially used as metal‐cation sensors.
ChemInform Abstract: Oxidation of 1,4‐Dihydropyridines and 3,4‐Dihydropyrimidin‐2(1H)‐ones to Substituted Pyridines and Pyrimidinones Using Ca(OCl)2 in Aqueous Media.
Authors: Tamaddon Fatemeh , Razmi Zahra 
Published: July 2011

AbstractAn environmentally benign and efficient oxidation reaction of the title compounds (I), (III) and (V) is presented.
ChemInform Abstract: Highly Regioselective Synthesis of Ethyl 2‐(N‐Methylformate‐1,4,5,6‐tetrahydropyridin‐2‐yl) Acetate and Its Conversion into Corresponding (R)‐Ethyl Homopepicolate by Asymmetric Hydrogenation.
Authors: Karame Iyad , Nemra‐Baydoun Ghinwa , Abdallah Radwan , Kanj Ali , Boerner Armin 
Published: July 2011

AbstractThe title compound (III) can be used as a precursor of β‐amino acids and as an intermediate in organic syntheses.
ChemInform Abstract: Monitoring the Aggregation Processes of Amyloid‐β Using a Spin‐Labeled, Fluorescent Nitroxyl Radical.
Authors: Yamada Ken‐ichi , et al. et al. 
Published: July 2011

AbstractThe fluorescent nitroxyl radical (I) promotes the aggregation of amyloid‐β peptide, whilst radical (II) suppresses the aggregation.
ChemInform Abstract: A General Strategy for the Synthesis of Cyclic N‐Aryl Hydroxamic Acids via Partial Nitro Group Reduction.
Authors: McAllister Laura A. , et al. et al. 
Published: July 2011

AbstractTreatment of p‐ and m‐substituted 2‐nitrophenylalanine derivatives like (IV) with SnCl2/ NaOAc allows a new access to cyclic hydroxamic acids which are of biological interest.
ChemInform Abstract: Facile N‐Alkylation of Acridine Esters with 1,3‐Propane Sultone in Ionic Liquids.
Authors: Natrajan Anand , Wen David 
Published: July 2011

AbstractThe N‐alkylation of poorly reactive acridine phenolic esters (I) with 1,3‐propane sultone (II) in ionic liquids affords excellent conversion to the commercially useful, chemiluminescent N‐sulfopropyl acridinium esters (III) using only a limited amount of the carcinogenic sultone reagent.
ChemInform Abstract: Asymmetric Synthesis of Pyrrolo[2,1‐a]isoquinoline Derivatives by 1,3‐Dipolar Cycloadditions of Stabilized Isoquinolinium N‐Ylides with Sulfinyl Dipolarophiles.
Authors: Garcia Ruano Jose Luis , Fraile Alberto , Martin M. Rosario , Gonzalez Gemma , Fajardo Cristina , Martin‐Castro Ana Maria 
Published: July 2011

AbstractThe title reaction allows an efficient and enantioselective access to highly functionalized pyrroloisoquinoline derivatives of biological interest.
ChemInform Abstract: Synthesis of Fused Bicyclic Systems with Nitrogen Atom at the Bridgehead, Including Indolizidines and Quinolizidines.
Authors: Pepe Antonella , Pamment Michael , Georg Gunda I. , Malhotra Sanjay V. 
Published: July 2011

AbstractAn efficient method to prepare title compounds such as (VII) and (XI) is reported.
ChemInform Abstract: Efficient Synthesis of 3‐Substituted 1,2,4‐Triazolo[4,3‐a]pyridine by [Bis(trifluoroacetoxy)iodo]benzene‐Catalyzed Oxidative Intramolecular Cyclization of Heterocyclic Hydrazones.
Authors: Padalkar Vikas S. , Patil Vikas S. , Phatangare Kiran R. , Umape Prashant , Sekar N. 
Published: July 2011

Abstract16 Title compounds (IV) are prepared by oxidative intramolecular cyclization.
ChemInform Abstract: Solvent‐Free Lipase‐Mediated Synthesis of Six‐Membered Cyclic Carbonates from Trimethylolpropane and Dialkyl Carbonates.
Authors: Pyo Sang‐Hyun , Persson Per , Lundmark Stefan , Hatti‐Kaul Rajni 
Published: July 2011

AbstractThe title compounds (III), (IV), and (VII) represents potential monomers for the synthesis of polyurethanes and polycarbonates.
ChemInform Abstract: Conventional and Microwave Induced Synthesis of Various Pyrimidine and Isoxazole Derivatives from 1‐{4′‐[(4′′‐Methylpiperazinyl)diazenyl] phenyl}‐3‐(substitutedphenyl)prop‐2‐en‐1‐one and Studies of Their Antimicrobial Activity.
Authors: Mistry B. D. , Desai K. R. , Rana P. B. 
Published: July 2011

AbstractAlmost all the new compounds (III), (V) and (VI) show mild to moderate antibacterial and antifungal activities.
ChemInform Abstract: FeCl3 Immobilized in Al‐MCM 41: An Efficient Catalyst System for the Biginelli Reaction.
Authors: Oskooie Hossein A. , Heravi Majid M. , Karimi Narges , Monjezy Maryam H. 
Published: July 2011

AbstractFeCl3 on Al‐MCM‐41 is shown to be an efficient catalyst for the Biginelli reaction for the synthesis of 3,4‐dihydropyrimidinone derivatives.
ChemInform Abstract: Efficient Synthesis of 3,4‐Dihydropyrimidin‐2‐ones in Low Melting Tartaric Acid—Urea Mixtures.
Authors: Gore Sangram , Baskaran Sundarababu , Koenig Burkhard 
Published: July 2011

AbstractA novel environmentally benign method for the synthesis of title compounds (IV), (VII), and (IX) using low melting mixtures as reaction medium is described.
ChemInform Abstract: Broensted Acidic Ionic Liquids: New, Efficient, and Green Promoter System for the Synthesis of 4(3H)‐Quinazolinones.
Authors: Heravi Majid M. , Tavakoli‐Hoseini Niloofar , Bamoharram Fatemeh F. 
Published: July 2011

AbstractThe catalyst can be recycled and reused without significant loss of activity.
ChemInform Abstract: Practical and Efficient Synthesis of 3‐Aryl‐2H‐benzo[1,4]thiazine Derivatives Catalyzed by KHSO4.
Authors: Baghernejad Bita , Heravi Majid M. , Oskooie Hossein A. 
Published: July 2011

AbstractA simple, clean, and cheap protocol for the synthesis of the title compounds (III) using a recyclable and reusable catalyst is presented.
ChemInform Abstract: Synthesis of 6,7‐Dihydro‐5H‐[1,3,4]thiadiazolo[2,3‐b][1,3]thiazinium System Derivatives.
Authors: Kim D. G. , Sudolova N. M. , Slepuhin P. A. , Charushin V. N. 
Published: July 2011

AbstractThe reaction of 1,3,4‐thiadiazole (III) with bromine and iodine leads to halocyclization products [cf.
ChemInform Abstract: Synthesis of Novel Heterocyclic System 9‐Methyl‐8‐phenyl‐1,4‐dihydro‐5H‐pyrazolo[5′,1′:2,3]pyrimido[4,5‐e] [1,2,4]triazepin‐5‐one.
Authors: Tchuvashlev A. S. , Shestakov A. S. , Krylskiy D. V. , Shikhaliev Kh. S. 
Published: July 2011

AbstractThe title compound (IV) is obtained in the reaction of carbohydrazide (II) with triethyl orthoformate.
ChemInform Abstract: Rhodium‐Catalyzed Oxidative Alkynylation of Acrylate Esters with Propargylic Alcohols.
Authors: Nishimura Takahiro , Nagaosa Makoto , Hayashi Tamio 
Published: July 2011

AbstractThe optimized conditions allow direct formation of the target compounds with high (E)‐selectivity (<90%).
ChemInform Abstract: Microwave‐Assisted Synthesis of Propesticides 1,3,4‐Thiadiazole Aminophosphonates.
Authors: Wan Rong , Wang Peng , Han Fen , Wang Yao , Zhang Jianqiang 
Published: July 2011

Abstract11 Title compounds of type (III) are prepared with improved yields using microwave irradiation.
ChemInform Abstract: Direct Transformation of Organosulfur Compounds to Organophosphorus Compounds: Rhodium‐Catalyzed Synthesis of 1‐Alkynylphosphine Sulfides and Acylphosphine Sulfides.
Authors: Arisawa Mieko , Watanabe Takuya , Yamaguchi Masahiko 
Published: July 2011

Abstract1‐Alkynylthio compounds are treated with disulfide (IIa) under optimized conditions to afford the desired products directly.
ChemInform Abstract: Stereoselective Synthesis and Characterization of (Z)‐(‐)‐4‐(1′‐Alkoxyl‐1′‐alkyloxycarbonyl‐methylidene)‐5(R)‐ [(1R)‐menthyloxy]‐γ‐butyrolactones.
Authors: Feng Zhiqiang , Yin Chenglie 
Published: July 2011

AbstractThe title compounds (IV) are synthesized under mild conditions.
ChemInform Abstract: Phragmalin‐Type Limonoid Orthoesters from Chukrasia tabularis var. velutina.
Authors: Luo Jun , Wang Jun‐Song , Wang Xiao‐Bing , Luo Jian‐Guang , Kong Ling‐Yi 
Published: July 2011

AbstractNine new phragmalin‐type limonoid orthoesters, tabulalides F‐N (I), (II) and (III), together with three known compounds are isolated from the stem bark of Chukrasia tabularis collected in China.
ChemInform Abstract: Robust Synthesis of Trifluoromethionine and Its Derivatives by Reductive Trifluoromethylation of Amino Acid Disulfides by CF3I/Na/Liq.NH3 System.
Authors: Yasui Hiroyuki , Yamamoto Takeshi , Tokunaga Etsuko , Shibata Norio 
Published: July 2011

AbstractThe reaction is suitable for multigram synthesis.
ChemInform Abstract: A New Approach to the Efficient Method for the Asymmetric Synthesis of (S)‐O‐, M‐, P‐Fluorophenylalanines and Their 2‐Methyl‐Substituted Analogues.
Authors: Saghiyan Ashot S. , Petrosyan Satenik G. , Manasyan Luiza L. , Dadayan Slavik A. , Geolchanyan Arpine V. , Panosyan Henry A. , Maleev Victor I. , Khrustalev Victor N. 
Published: July 2011

AbstractThe compounds (III) and (IV) are separated by preparative chromatography.
ChemInform Abstract: New Diketopiperazine Derivatives Isolated from Sea Urchin‐Derived Bacillus sp.
Authors: Yonezawa Ken , Yamada Koji , Kouno Isao 
Published: July 2011

Abstractisolation, structure elucidation and biological activity of the new diketopiperazine derivatives bacillusamides A (Ia) and B (b)
ChemInform Abstract: Flavonoid Glycosides from Chromolaena odorata Leaves and Their in vitro Cytotoxic Activity.
Authors: Hung Tran Manh , Cuong To Dao , Dang Nguyen Hai , Zhu Shu , Long Pham Quoc , Komatsu Katsuko , Min Byung Sun 
Published: July 2011

AbstractTwo new flavonoid glycosides (I) and (II) are isolated along with eleven known compounds.
ChemInform Abstract: Regioselective Synthesis of 5‐Trifluoromethyl‐1,2,3‐triazole Nucleoside Analogues via TBS‐Directed 1,3‐Dipolar Cycloaddition Reaction.
Authors: Xiong Zhiru , Qiu Xiao‐Long , Huang Yangen , Qing Feng‐Ling 
Published: July 2011

AbstractAntivirus and cytotoxicity evaluation of the title compounds are in progress and will be reported soon.
ChemInform Abstract: Some Novel Thiopyrimidine Nucleoside Analogues: Synthesis and in vitro Antimicrobial Evaluation.
Authors: Rashand Aymn E. , Shamroukh Ahmed H. , Sayed Hayam H. , Awad Samir M. , Abdelwahed Nayera A. M. 
Published: July 2011

AbstractAmong the tested compounds the nucleoside analogue (III) exhibits the highest antimicrobial activity.
ChemInform Abstract: Oxygenated Hexylitaconates (I) from a Marine Sponge‐Derived Fungus Penicillium sp.
Authors: Li Jian Lin , Zhang Ping , Lee Yoon Mi , Hong Jongki , Yoo Eun Sook , Bae Kyung Sook , Jung Jee H. 
Published: July 2011

Abstractisolation, structure determination and cytotoxicity
ChemInform Abstract: Total Synthesis of Pactamycin.
Authors: Hanessian Stephen , Vakiti Ramkrishna Reddy , Dorich Stephane , Banerjee Shyamapada , Lecomte Fabien , DelValle Juan R. , Zhang Jianbing , Deschenes‐Simard Benoit 
Published: July 2011

AbstractThe compound is synthesized in 29 linear steps and 3% overall yield starting from a known oxazoline readily available from L‐threonine.
ChemInform Abstract: Chemoenzymatic Synthesis of (2R,6R,10R)‐6,10,14‐Trimethylpentadecan‐2‐ol, Sex Pheromone of Rice Moth (Corcyra cephalonica), and of Its (2S,6R,10R)‐Diastereomer.
Authors: Shafikov R. V. , Spivak A. Yu. , Odinokov V. N. 
Published: July 2011

AbstractThe kinetic separation of the diastereomeric title alcohols is accomplished by their acylation with succinic anhydride in the presence of lipase Amano PS.
ChemInform Abstract: Highly Magnetic Core—Shell Nanoparticles with a Unique Magnetization Mechanism.
Authors: Yoon Tae‐Jong , Lee Hakho , Shao Huilin , Weissleder Ralph 
Published: July 2011

AbstractHighly magnetic nanoparticles Fe@Fe3O4 for biomedical use are prepared by thermal decomposition of Fe(CO)5 in the presence of oleylamine followed by exposure to air and addition of Fe‐oleate complexes (300 °C, 1 h).
ChemInform Abstract: Facile Synthesis of Silver Chalcogenide (Ag2E; E: Se, S, Te) Semiconductor Nanocrystals.
Authors: Sahu Ayaskanta , Qi Lejun , Kang Moon Sung , Deng Donna , Norris David J. 
Published: July 2011

AbstractStructurally well‐defined and nearly monodisperse colloidal Ag2Se nanocrystals are synthesized from tri‐n‐octylphosphine solutions containing AgNO3, Se, oleic acid, 1‐octadecylamine, and 1‐octadecene (150 °C, about 5 min).
ChemInform Abstract: Thiadiazole‐Containing Macrocyclic Compounds as Core‐Modified Analogues of Phthalocyanine
Authors: Danilova Elena A. , Melenchuk Tat'yana V. , Trukhina Olga N. , Zakharov Alexander V. , Islyaikin Mikhail K. 
Published: July 2011

AbstractReview: 26 refs.
ChemInform Abstract: Further Application of the Multi‐Template Approach for Creation of Biological Response Modifiers: Discovery of a New Class of Multifunctional Antidiabetic Agents
Authors: Motoshima Kazunori , Noguchi‐Yachide Tomomi , Ishikawa Minoru , Hashimoto Yuichi , Sugita Kazuyuki 
Published: July 2011

AbstractReview: 77 refs.
ChemInform Abstract: Histamine H1 Receptor Gene as an Allergic Diseases‐Sensitive Gene and Its Impact on Therapeutics for Allergic Diseases
Authors: Mizuguchi Hiroyuki , Kitamura Yoshiaki , Kondo Yuto , Kuroda Wakana , Yoshida Haruka , Miyamoto Yuko , Hattori Masashi , Takeda Noriaki , Fukui Hiroyuki 
Published: July 2011

AbstractReview: 13 refs.
ChemInform Abstract: Health Effects of Nanomaterials on Next Generation
Authors: Takeda Ken , Shinkai Yusuke , Suzuki Ken‐ichiro , Yanagita Shinya , Umezawa Masakazu , Yokota Satoshi , Tainaka Hitoshi , Oshio Shigeru , Ihara Tomomi , Sugamata Masao 
Published: July 2011

AbstractReview: 42 refs.
Enhancement of Biogas Generation by Addition of Lipase in the Co‐Digestion of Tannery Solid Wastes
Authors: Sri Bala Kameswari Kanchinadham , Kalyanaraman Chitra , Porselvam Subramanian , Thanasekaran Kumarasami 
Published: July 2011

AbstractCo‐digestion studies were carried out for biogas generation using fleshings as the primary substrate and a mixture of primary and secondary sludge generated during the treatment of tannery wastewater as the co‐substrate. Steapsin, a commercial grade lipase, was added to enhance the hydrolysis in anaerobic co‐digestion. The lipase dosages used were ranging between 0.25 and 1.0 g for a volatile solids input of 7.5 g. The performance of the co‐digestion was assessed from the volume of biogas generated. Experimental results revealed an optimum lipase dosage of about 0.75 g. At this dosage, the biogas generation was observed to increase by about 15% compared to that in the control without adding lipase. Further, the digestion with lipase addition was observed faster since the digestion period was reduced about 30%. This means that the capacity of the digester could also be reduced about 30% leading to savings in its installation cost.
Yolk sac endoderm is the major source of serum proteins and lipids and is involved in the regulation of vascular integrity in early chick development
Authors: Nakazawa Fumie , Alev Cantas , Jakt Lars M. , Sheng Guojun 
Published: July 2011

AbstractAn important function of the vascular system is nutrient delivery. In adult animals, this is mediated through a close contact of the mesoderm‐derived vasculature with the endoderm‐derived enterocytes and hepatocytes. During embryonic development, the yolk sac (YS) endoderm has been suggested to play a similar role. Physiological and molecular nature of the contact between the YS endoderm and the vasculature is not well‐understood. To understand roles of the YS endoderm in early development, we used the avian model and carried out a gene expression profiling analysis of isolated area vasculosa YS endoderm tissues from embryonic day 2–4 chick embryos, covering the first 48 hr of postcirculation development. Genes involved in lipid metabolism are highly enriched, indicating an active modification of lipid components during their transfer from the yolk to the circulatory system. We also uncovered genes encoding major serum proteins and key regulators of vascular integrity. In particular, PTGDS, an enzyme controlling the last step of prostaglandin D2 production, shows high expression in the YS endoderm. Experimental introduction of prostaglandin D2 into embryonic circulation led to intraembryonic vessel rupture. These data suggest that the YS endoderm is the major, if not exclusive, source of lipid and protein constituents of the early embryonic serum and plays an important role in the regulation of vascular integrity in developing embryo. Developmental Dynamics 240:2002–2010, 2011. © 2011 Wiley‐Liss, Inc.