bluuebunny/crossref_metadata_2025_split huggingface dataset:
Data Evaluation Framework for Refining PFAS Conceptual Site Models
Authors: Gamlin Jeff , Newell Charles J. , Holton Chase , Kulkarni Poonam R. , Skaggs Jonathan , Adamson David T. , Blotevogel Jens , Higgins Christopher P. 
Published: June 2024

AbstractContaminated sites with per‐ and polyfluoroalkyl substances (PFASs) are the cause of environmental, health, and financial concerns. Understanding and addressing PFASs at their source areas is important for effective characterization, risk assessment, and remediation. This paper introduces a framework that relies on commonly available PFAS data to assist in identifying PFAS source areas and assess PFAS fate and transport considerations along flowpaths. Currently accepted PFAS physical and chemical behaviors have been incorporated into metrics that can be evaluated geospatially, and/or over time, to build a weight‐of‐evidence approach to refine conceptual site models (CSMs). Graphical representation of data according to a PFAS “family tree” is also proposed for more consistent interpretation and pattern recognition. Combined, these tools create a PFAS data evaluation framework (PFAS Framework) that consists of a tiered analysis approach based on data availability and site complexity. Case studies from real sites are presented to demonstrate the capabilities of the PFAS Framework in identifying source areas.
Salivary duct carcinoma with squamous differentiation: histomorphological and immunophenotypical analysis of six cases
Authors: Dababneh Melad N , Griffith Christopher C , Magliocca Kelly R , Stojanov Ivan J 
Published: June 2024

Background and aimsSalivary duct carcinoma (SDC) is an aggressive salivary malignancy with multiple morphological subtypes. Primary salivary squamous cell carcinoma (SCC) requires exclusion of high‐grade salivary malignancies and metastatic disease and is considered exceptionally rare. We report six cases of SDC with resemblance to SCC on account of variable, but often extensive, squamous differentiation.Methods and resultsA retrospective review (2009–2023) at two institutions of SDC with histological and immunophenotypical evidence of squamous differentiation identified six cases. Medical charts and available glass slides were reviewed. There were five males and one female with a median age of 63 years, with tumours involving the parotid (five of six) and submandibular (one of six) glands. All six tumours showed a conventional SDC component comprising < 5–90% of viable tumour. Squamous differentiation comprised 10–95%+ (> 75% in three of six cases) of total viable tumour, and demonstrated CK5/6, p63 and/or p40 immunoexpression in all cases. A sarcomatoid component, comprising 10–60% of viable tumour, was present in three of six (50%) cases. All tumours were androgen receptor (AR)‐positive, but only two of six (33.3%) retained AR immunoreactivity in the squamous component. Metastatic SDC to regional lymph nodes exhibited exclusive squamous differentiation in two of six (33.3%) cases.ConclusionSquamous differentiation, histologically and immunophenotypically, can be extensive in SDC. AR expression may be lost in the squamous component and metastases may demonstrate only squamous differentiation. These findings cast further doubt on the existence of primary salivary SCC. SDC should be considered whenever encountering a carcinoma with squamous differentiation in major salivary glands or within cervical lymph nodes in the setting of a salivary mass.
A comparative study on the slag resistance of MgO–C, low‐carbon MgO–C, and MgO–SiC–C refractories
Authors: Qi Xin , Luo Xudong , Gu Huazhi , Cao Lei , Tao Ying , Hou Qingdong 
Published: June 2024

AbstractThe corrosion of slag on refractories usually starts from the matrix, so improving the slag resistance of the matrix is of great significance for the slag resistance of the refractories. To clarify the influence of matrix on the slag resistance of magnesia–carbon refractories, the slag corrosion experiments were conducted at 1873 K on MgO–C refractories, low‐carbon MgO–C refractories, and MgO–SiC–C refractories. The results showed that the slag resistance of MgO–C refractories was higher than that of low‐carbon MgO–C refractories, and the slag resistance of MgO–SiC–C refractories was superior to that of low‐carbon MgO–C refractories. The interaction between MgO–SiC–C refractories and slag generated high melting point phases such as forsterite and spinel, reducing the routes for the slag to infiltrate the inside of the refractories. MgO–SiC–C refractories reacted with slag to increase the viscosity of the slag, the viscosity being 86.3% and 51.9% higher than in the case of low‐carbon MgO–C and MgO–C refractories, respectively. Compared with MgO–SiC–C refractories, MgO–C refractories did not exhibit overwhelming advantages in slag resistance. Due to the low‐carbon content and good slag resistance, MgO–SiC–C refractories were promising low‐carbon magnesia‐based refractories for high‐temperature industries.
Pyroplastic deformation analysis of Brazilian porcelain tile formulations using mixture design
Authors: Elias Rodrigo , Zaccaron Alexandre , Montedo Oscar Rubem Klegues , Raupp‐Pereira Fabiano , Bernardin Adriano Michael , Arcaro Sabrina , Rodrigues Neto João Batista 
Published: June 2024

AbstractPyroplastic deformation is still an important defect caused during firing in the manufacture of porcelain tiles when there is no control over the raw materials used in the formulation of ceramic tiles. The present study used mixing design as a tool in the development of pastes formulations for Brazilian porcelain tile manufacturing in order to reduce their pyroplastic deformation. Ceramic industry in Brazil has typical and complex way to set up porcelain tile formulations, using regularly more than a dozen raw materials. Therefore, the originality in this work was understanding the formulation by means of a pseudocomponent‐based approach (multiminerals triaxial diagram) and defining parameters that minimize that problem. Eleven different raw materials, supplied by Brazilian ceramic manufacturer, were used and characterized according to their physical–chemical properties. Later, raw materials were divided into three chemical categories and through a simplex‐centroid mixture design, defining the maximum limit of feldspar in 70%, 10 formulations in the experimental region were defined. All formulations were analyzed for particle size distribution, bulk density (postpressing and postburning), mechanical strength (postpressing and postfiring), thermal shrinkage, water absorption, and pyroplastic deformation. Thus, formulations that presented the most admissible behavior in the manufacture of porcelain tiles were selected, and tests were carried out for chemical, mineralogical, thermal (differential scanning calorimeter [DSC]/thermogravimetric [TG]), thermal expansion, porosity analysis, and optical fleximeter (pyroplasticity). All results were analyzed using response surfaces with data obtained by analysis of variance (ANOVA). Mixture design method proved to be a valuable tool to observe the behavior of raw materials and to optimization of Brazilian porcelain tile formulations.
Influence of Aspergillus parasiticus on aflatoxins production and quality change in Chrysanthemum morifolium at various storage conditions
Authors: Chen Meixu , Wang Liling , Huo Xinyi , Xu Qilin , Ying Yaofeng , Wu Linlin , Zhou Yifeng , Huang Jun 
Published: June 2024

SummaryIn this study, a full factorial design with three temperature levels (20, 30 and 40 °C), three moisture content (MC) levels (8%, 15% and 22%), and four storage times (7, 14, 21 and 28 days) was used to investigate the changes of aflatoxins (AFs), active constituents, and antioxidant activities in Hangbaiju (HBJ, Chrysanthemum morifolium) after simulated inoculation with Aspergillus parasiticus. The results showed that AFs could be produced in the range of 20~30 °C and 8~22% MC after mould infection, but both mould growth and AFs production were inhibited under the tested MC condition at 40 °C. The analysis of variance (anova) indicated that the temperature, time, interaction between the temperature and time, and interaction between MC and time had significant effects on the total aflatoxins (AFTOT) accumulation. Under 20 and 30 °C, AFTOT in inoculated HBJ usually increased with the increase of MC and storage time, while its active constituents and antioxidant activities decreased with the increase of AFTOT under corresponding storage conditions. Pearson correlation analysis suggested that relatively stronger negative correlations were observed between luteolin‐7‐O‐glucoside (LUT7G), total phenolic content (TPC), total flavonoid content (TFC), and AFTOT. Grey correlation analysis (GCA) showed that antioxidant activity was highly linked to the content of active constituents, and the characteristic flavonoid LUT7G exhibited the highest grey correlation degrees (GCDs) in the three antioxidant activities. The AFTOT reached the highest level (31.15 μg kg−1) after 28 days of storage at 30 °C and 22% MC; meanwhile, LUT7G, TPC and TFC decreased by 93.66%, 20.77% and 55.50%, respectively, and all the three antioxidant activities indicated more than 25% reduction. This is the first study about the changes and relationships of AFTOT, active constituents and bioactivities in the medicinal food influenced by A. parasiticus under different storage conditions. These results provide important references to prevent AFs production and quality control for HBJ and other medicinal foods influenced by A. parasiticus in storage strategy.
Incorporation of ground mustard seeds in an active packaging film: structural properties and controlled release of allyl isothiocyanate
Authors: Bahmid Nur Alim , Suloi Andi Nur Fajri , Anwar Muslih , Prasetyo Dwi Joko , Wahono Satriyo Krido , Hernawan  
Published: June 2024

SummaryGround mustard seeds can be incorporated into a packaging film material to have a controlled release of allyl isothiocyanates (AITC). However, the properties of film material loaded with ground mustard seeds need to be evaluated, since they might influence the release of AITC from the film materials. This study aimed to assess properties, including surface morphology, spectral analysis, crystallinity, the moisture‐related, thermal and mechanical properties, of the film materials incorporated with the ground seeds and the release of antimicrobial compounds. Furthermore, the effects of relative humidity on AITC release in the headspace were investigated. The results showed that incorporating a larger quantity of ground mustard seeds resulted in the quicker release of AITC due to direct exposure to moisture, as indicated by higher concentrations observed in the headspace. Meanwhile, a smaller quantity of ground seeds added to the film maintained the thermal properties of the materials until 100 °C, resulting in significantly better moisture‐related properties and higher mechanical strength in terms of tensile strength, elastic modulus, and strain at break. However, the smallest ratio (1:5) showed no release of AITC into the packaging headspace at 75% and 100% RH. Furthermore, the relative humidity led to the release of more AITC in the headspace, which is potentially applied for high‐moisture food products. Based on the influence of relative humidity on AITC concentrations, the mechanism of AITC release from the film materials is proposed, describing the AITC diffusion from ground mustard seeds, film, and headspace.
Effects of the composition of food and medicine homologous ingredients complex supplementation on lipid metabolism and gut microbiota diversity in high‐fat diet‐induced obese mice
Authors: Ma Jiajie , Cui Mingxun , Wang Jianan , Li Kun , Li Siyi , Piao Chunxiang , Wang Juan , Mu Baide , Li Guanhao , Li Hongmei 
Published: June 2024

SummaryDietary patterns are closely related to obesity, and a balanced diet can prevent obesity more than a single food or nutrient. In this study, we investigated the anti‐obesity effects of food and medicine homologous ingredient complex (FMHIC). The serum biochemical indices related to lipid metabolism were significantly improved in the FMHIC group. Meanwhile, it significantly inhibited the accumulation of lipid droplets, improved adipocyte hypertrophy and downregulated gene expression related to lipid production. FMHIC can effectively regulate intestinal flora richness and structural disorder in obese mice and result in a higher abundance of NK4A214_group and Prevotellaceae _UCG_001, and a lower abundance of Negativibacillus, Lachnospiraceae_NK4A136_group, Lachnoclostridium and GCA_900066575. Spearman correlation analysis showed that there was a strong correlation between species richness and lipid metabolism and that FMHIC might adjust lipid metabolism by regulating the abundance of intestinal flora. In conclusion, FMHIC regulates lipid metabolism and modulates gut microbiota to regulate high‐fat diet‐induced dysbiosis.
Identification and molecular mechanisms of novel antioxidant peptides in black soldier fly larvae protein: simulated gastrointestinal digestion, molecular docking and in vitro/in vivo studies
Authors: Huang Wangxiang , Wang Chen , Chen Qianzi , Chen Feng , Hu Haohan , Li Jianfei , Kang Jingling , He Qiyi , Yu Xiaodong 
Published: June 2024

SummaryThis study aims to identify novel antioxidant peptides within black soldier fly larvae protein (BSFLP) using simulated gastrointestinal processes, LC–MS/MS analysis, and virtual screening. Two peptides, PFCPK and ADFW, exhibited significant antioxidant properties in both in vitro radical scavenging experiments and in vivo evaluations using zebrafish embryos induced with 2,2′‐azobis(2‐methylpropionamidine) dihydrochloride. Treatment with 25 μg mL−1 of PFCPK or ADFW significantly (P < 0.05) enhanced zebrafish embryo survival, reduced abnormal heartbeats and lowered ROS generation rate by 62.98% and 83.44%, lipid peroxidation by 52.54% and 68.35%, and cell death rate by 86.92% and 97.54%, respectively. Moreover, they restored antioxidant enzyme activities and MDA levels to near‐normal values, demonstrating significant therapeutic effects. The observed antioxidant effects may potentially be linked to the modulation of the Keap1/Nrf2 pathway. This study provides valuable insights for developing novel natural antioxidants and maximising the high‐value applications of BSFLP.
State temporary assistance for needy families policies and high school diploma or equivalent attainment among mothers following a nonmarital birth: An event history analysis
Authors: Oh Sehun , Radey Melissa , Smith Briana , Powers Daniel A. 
Published: June 2024

AbstractThis study examines high school diploma or equivalent (HS/E) attainment by mothers who had a nonmarital birth (“unmarried mothers”) and the associations between state‐level Temporary Assistance for Needy Families (TANF) policies and their postnatal HS/E attainment. Using an analytic sample of 1154 unmarried mothers without HS/E from the restricted‐use Future of Families and Child Wellbeing Study, we tracked postnatal HS/E attainment patterns for 15 years, and conducted discrete‐time event history analysis with mixed effects to test the relationships between states' TANF policies and postnatal HS/E attainment. Only 35.1% of the sample attained HS/E after childbirth, while nearly half of mothers who attained HS/E were not able to do so within 3 years of childbirth. A $100 higher maximum monthly benefit amount is associated with 86.1% higher odds of postnatal HS/E attainment, indicating the need to consider increasing TANF benefit amounts as a means to promote educational attainment among unmarried mothers with educational disadvantages.
Between war and peace: Exploring the role of refugee law in the context of Sudan political conflict
Authors: Sapre Abhilash Arun , Singh Shalini 
Published: June 2024

AbstractThe ongoing political turmoil gripping Sudan is fraught with violence between two opposing factions within its military government. This unsettling state of affairs has led to devastating consequences, including large‐scale displacement of people and severe human rights violations, causing dire humanitarian consequences. Against this tumultuous backdrop, we explore how existing refugee law, one facet of international law governing refugees, can help bring relief amidst a volatile conflict zone. Examining complex legal questions ranging from determining who qualifies for asylum status through various geographic considerations to what role states play in securing basic protections for refugees fleeing persecution or war at home will be analysed herein. Further difficulties involving how these complex provisions protect refugees face hurdles due to practical factors like lack of resources or security concerns will be considered thoroughly. While recognizing that instituting legal reforms alone is not enough to address these complex crises due to various challenges of reasons ranging from political to practical, this paper concludes by putting forth strategic recommendations for improvement aimed towards bolstering resources and support mechanisms required for refugees across the region to ensure they can seize‐hold of eventual solutions.
Comprehensive social and medical security for Ukrainian migrant workers: Degree of protection
Authors: Hanechko Olena M. , Pavlichenko Helena V. , Bielousov Volodymyr D. , Platonova Hanna V. , Dyachenko Ol'ha A. 
Published: June 2024

AbstractLabour migration is one of the features of the modern labour market. The development of transport infrastructure, the spread of non‐standard forms of employment, the globalization of all spheres of human activity and the growing unevenness of territorial development led to an increase in the mobility of the economically active population. In addition, various environmental disasters or military actions, such as the Russian Federation's war against Ukraine in February 2022, have an impact on the spread of migration. Labour migration undoubtedly contributes to the redistribution of labour and the efficiency of human capital. At the same time, like most other manifestations of a flexible labour market, labour migration poses a threat to weakening the social protection of workers, and therefore requires new, non‐standard approaches to the organization of social security. Several scientific methods were used to conduct the study, including general scientific approaches such as dialectic, analysis, synthesis, abstraction and analogy. In addition, specific legal methods were used, in particular, formal legal, comparative legal and systemic‐structural approaches. The purpose of this article is to study the current state of legislation and state policy on the social security of labour migrants. The aim is to identify existing problems and develop recommendations for their solution with the ultimate goal of improving the social protection of labour migrants.
Radiographic outcomes of lateral sinus floor elevation at sites without perforations and sites with perforations managed with a resorbable membrane: A retrospective study
Authors: Wang Zhikang , Wang Yuchen , Yu Zhou , Tang Like , Zhang Jing , Yang Guoli , Huang Tingben 
Published: June 2024

AbstractAimTo evaluate the radiographic outcomes of lateral sinus floor elevation with simultaneous implant placement at sites without sinus membrane perforation (SMP) and sites with SMP managed with a resorbable membrane.Materials and MethodsOne hundred and thirty‐nine patients and 170 implants (56 perforation, 114 non‐perforation) were included. Cone‐beam computed tomography (CBCT) images were taken before surgery (T0), immediately after surgery (T1) and 6 months after surgery (T2). Post‐operative augmentation parameters, including endo‐sinus bone gain (ESBG) along the implant axis, mean new bone height (NBH) surrounding the implant and augmentation volume (AV), were measured at T1 and T2.ResultsAt T1, there were no significant differences in ESBG, NBH and AV between the two groups. At T2, although ESBG did not significantly differ between the two groups, NBH (8.50 ± 1.99 mm vs. 9.99 ± 2.52 mm, p = .039) and AV (519.37 ± 258.38 mm3 vs. 700.99 ± 346.53 mm3, p < .001) were significantly lower in the perforation group. The shrinkage of graft material from T1 to T2, including ΔESBG (p = .002), ΔNBH (p < .001) and ΔAV (p < .001), was higher in the perforation group.ConclusionsSMP during LSFE with simultaneous implant placement is associated with greater resorption of the grafted area at a 6‐month follow‐up.
Efficacy and safety of a topical skincare regimen containing CE Ferulic serum and resveratrol BE serum following ablative fractional CO2 laser treatment: A prospective, randomized, split‐face, controlled trial
Authors: Shi Yu , Shen Chen , Zhang Wei 
Published: June 2024

AbstractBackgroundAblative fractional CO2 laser is widely used to address various skin problems, but the treatment often leads to adverse effects such as erythema, dyspigmentation, and extended recovery periods, negatively impacting patients' quality of life.ObjectivesThis study aimed to evaluate the efficacy and safety of a topical skincare regimen containing both CE Ferulic serum and Resveratrol BE night serum following fractional CO2 laser treatment in Chinese population.MethodsIn this randomized, investigator‐blinded, split‐face, controlled trial, individuals aged 18–65 undergoing ablative CO2 laser treatment were randomly assigned to apply CE Ferulic plus resveratrol BE serum (CEF‐RBE) to either side of face and normal saline (NS) to the other, for 14 consecutive days. The primary endpoint was erythema index (EI) on day 14, with key secondary endpoints including scabbing detachment time, percentage changes in EI and melanin index (MI), skin hydration, transepidermal water loss, skin sebum content, oedema, and overall subject satisfaction.ResultsThe study included 51 patients, of whom 29 (56.9%) were female, with a mean (SD) age of 29.8 (5.39) years. On day 14, the CEF‐RBE side exhibited significantly lower EI than the NS side (308.9 vs. 325.3, p = 0.034). The median (IQR) time (days) for complete scabbing detachment at the CEF‐RBE side was 6.0 (5.0–8.0) compared to 6.5 (5.0–9.0) at NS side (p = 0.018). Additionally, the CEF‐RBE side showed a 7.4% decrease in MI from baseline to day 14, while the NS side experienced a 0.2% increase (Δ = −7.6%, p = 0.044). Throughout the 14‐day follow‐up, the CEF‐RBE side consistently displayed higher skin hydration than the NS side.ConclusionsThe study highlighted the benefits of incorporating CEF‐RBE following laser treatment in reducing erythema and hyperpigmentation, promoting wound healing, and maintaining skin hydration, although limitations such as contamination and adherence issues should be considered.