bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cyclipostins, Novel Hormone‐Sensitive Lipase Inhibitors from Streptomyces sp. DSM 13381. Part 2. Isolation, Structure Elucidation and Biological Properties.
Authors: Vertesy Laszlo , Beck Bernd , Broenstrup Mark , Ehrlich Klaus , Kurz Michael , Mueller Guenter , Schummer Dietmar , Seibert Gerhard 
Published: May 2010

AbstractFor Abstract see ChemInform Abstract in Full Text.
Photoreactions of LaTiO2N under Visible Irradiation.
Authors: Kashara Asako , Nukumizu Kota , Hitoki Go , Takata Tsuyoshi , Kondo Junko N. , Hara Michikazu , Kobayashi Hisayoshi , Domen Kazunari 
Published: May 2010

AbstractFor Abstract see ChemInform Abstract in Full Text.
Construction of Terminal Conjugated Enynes: Regio‐ and Stereoselective Syntheses of 3‐Alken‐1‐ynes and 1‐Trimethylsilyl‐3‐alken‐1‐ynes from Alkenyldialkylboranes and (Trimethylsilyl)ethynyl Bromide.
Authors: Hoshi Masayuki , Shirakawa Kazuya 
Published: May 2010

AbstractFor Abstract see ChemInform Abstract in Full Text.
Stereoselective Synthesis of Polysubstituted 2,5‐Dihydrofurans from Reaction of 1,4‐Dilithio‐1,3‐dienes with Aldehydes.
Authors: Chen Jinglong , Song Qiuling , Li Pixu , Guan Hairong , Jin Xianglin , Xi Zhenfeng 
Published: May 2010

AbstractFor Abstract see ChemInform Abstract in Full Text.
Sequential Functionalization of Pyrazole 1‐Oxides via Regioselective Metalation: Synthesis of 3,4,5‐Trisubstituted 1‐Hydroxypyrazoles.
Authors: Paulson Anna Sif , Eskildsen Joergen , Vedsoe Per , Begtrup Mikael 
Published: May 2010

AbstractFor Abstract see ChemInform Abstract in Full Text.
The Synthesis and Structure—Activity Relationships of 4‐Aryl‐3‐aminoquinolin‐2‐ones: A New Class of Calcium‐Dependent, Large Conductance, Potassium (Maxi‐K) Channel Openers Targeted for Post‐Stroke Neuroprotection.
Authors: Hewawasam Piyasena , Fan Wenhong , Knipe Jay , Moon Sandra L. , Boissard Christopher G. , Gribkoff Valentin K. , Starrett Jr. John E. 
Published: May 2010

AbstractFor Abstract see ChemInform Abstract in Full Text.
New Sesquiterpenes from Ferula ferulaeoides (Steud.) Korovin. Part 6. Isolation and Identification of Three New Dihydrofuro[2,3‐b]chromones.
Authors: Nagatsu Akito , Isaka Kimio , Kojima Keisuke , Ondognii Purev , Zevgeegiin Oyun , Gombosurengyin Purevsuren , Davgiin Khishgee , Irfan Baig , Iqubal Choudhary Muhammad , Ogihara Yukio 
Published: May 2010

AbstractFor Abstract see ChemInform Abstract in Full Text.
Two New Steroidal Saponins from “Gualou‐xiebai‐baijiu‐tang” Consisting of Fructus trichosanthis and Bulbus allii macrostemi.
Authors: He Xiangjiu , Qiu Feng , Shoyama Yukihiro , Tanaka Hiroyoki , Yao Xinsheng 
Published: May 2010

AbstractFor Abstract see ChemInform Abstract in Full Text.
Convenient, Large‐Scale Asymmetric Synthesis of β‐Aryl‐Substituted α,α‐Difluoro‐β‐amino Acids.
Authors: Soloshonok Vadim A. , Ohkura Hironari , Sorochinsky Alexander , Voloshin Natalia , Markovsky Andrey , Belik Michael , Yamazaki Takashi 
Published: May 2010

AbstractFor Abstract see ChemInform Abstract in Full Text.
Synthesis and Antibacterial Activity of 1β‐Methylcarbapenems Having a 2,2‐Disubstituted‐1,3‐diazabicyclo[3.3.0]octan‐4‐one Moiety and Related Compounds. Part 3.
Authors: Oh Chang‐Hyun , Dong Hyun‐Gu , Cho Han‐Won , Park Sung Jin , Hong Joon Hee , Baek Daejin , Cho Jung‐Hyuck 
Published: May 2010

AbstractFor Abstract see ChemInform Abstract in Full Text.
Polymerizable Complex Synthesis of Pure Sr2NbxTa2‐xO7 Solid Solutions with High Photocatalytic Activities for Water Decomposition into H2 and O2.
Authors: Yoshino Mayu , Kakihana Masato , Cho Woo Seok , Kato Hideki , Kudo Akihiko 
Published: May 2010

AbstractFor Abstract see ChemInform Abstract in Full Text.
Facile Cleavage of Triethylsilyl (TES) Ethers Using o‐Iodoxybenzoic Acid (IBX) Without Affecting tert‐Butyldimethylsilyl (TBS) Ethers.
Authors: Wu Yikang , Huang Jia‐Hui , Shen Xin , Hu Qi , Tang Chao‐Jun , Li Liang 
Published: May 2010

AbstractFor Abstract see ChemInform Abstract in Full Text.
5,5‐Dimethyl‐1,4,2‐dioxazoles as Versatile Aprotic Hydroxamic Acid Protecting Groups.
Authors: Couturier Michel , Tucker John L. , Proulx Caroline , Boucher Ghislain , Dube Pascal , Andresen Brian M. , Ghosh Arun 
Published: May 2010

AbstractFor Abstract see ChemInform Abstract in Full Text.
Annulation of 3‐[(R)‐p‐Toluenesulfinyl]‐2‐oxopropylidenetriphenylphosphorane with 1,4‐Enediones; Highly Enantioselective Synthesis of Cyclopentenones.
Authors: Shinohara Yoshiaki , Kurata Takaaki , Kitano Hiroyoshi , Matsumoto Kazutsugu , Takahashi Ichiro , Hosoi Shinzo , Ota Tomihisa , Hatanaka Minoru 
Published: May 2010

AbstractFor Abstract see ChemInform Abstract in Full Text.
Cyclopropyl Building Blocks for Organic Synthesis. Part 82. Easy Access to (n + 3)‐Dimethylamino‐1‐ethenylbicyclo[n.1.0]alkanes and Their Facile Conversion to Ring‐Anellated Cyclopentadienes.
Authors: Voigt Tobias , Winsel Harald , de Meijere Armin 
Published: May 2010

AbstractFor Abstract see ChemInform Abstract in Full Text.
Translocation of the 5‐Alkoxy Substituent of 2,5‐Dialkoxyarylalkylamines to the 6‐Position: Effects on 5‐HT2A/2C Receptor Affinity.
Authors: Chambers James J. , Kurrasch‐Orbaugh Deborah M. , Nichols David E. 
Published: May 2010

AbstractFor Abstract see ChemInform Abstract in Full Text.
Nucleophilic Additions of the Cyanide Anion to 4,4‐Dichloro‐1,1‐diphenyl‐2‐azabuta‐1,3‐diene.
Authors: Jacquot‐Rousseau Sandrine , Schmitt Gerard , Laude Bernard , Kubicki Marek M. , Blacque Olivier 
Published: May 2010

AbstractFor Abstract see ChemInform Abstract in Full Text.
Syntheses of Optically Active Tetrahydro‐1H‐pyrrolo[1,2‐α]imidazol‐2‐ones and Hexahydroimidazo[1,2‐α]pyridin‐2(3H)‐ones.
Authors: Katritzky Alan R. , He Hai‐Ying , Wang Jing 
Published: May 2010

AbstractFor Abstract see ChemInform Abstract in Full Text.
Regioselective and Diastereoselective Phosphine‐Catalyzed [3 + 2] Cycloadditions to 5‐Methylenehydantoins; Reversal of Regioselectivity Using Chiral N‐2‐Butynoyl‐(4S)‐benzyloxazolidinone.
Authors: Pham Tien Q. , Pyne Stephen G. , Skeleton Brian W. , White Allan H. 
Published: May 2010

AbstractFor Abstract see ChemInform Abstract in Full Text.
1,3‐Dipolar Cycloaddition of β‐Alkoxyvinyl Trifluoromethyl Ketones with Aryl (or Benzyl) Azides. Synthesis of 4‐Trifluoroacetylated 1H‐1,2,3‐Triazoles.
Authors: Peng Wei‐min , Zhu Shi‐Zheng 
Published: May 2010

AbstractFor Abstract see ChemInform Abstract in Full Text.
Efficient Synthesis of Polyfunctionalized Pyridines by Conjugate Addition of 2‐Thienylcarbonyl (Thioacetanilides) to αβ‐Unsaturated Nitriles.
Authors: Bogdanowicz‐Szwed Krystyna , Krasodomska Malgorzata 
Published: May 2010

AbstractFor Abstract see ChemInform Abstract in Full Text.
InCl3‐Catalyzed Domino Reaction of Aromatic Amines with Cyclic Enol Ethers in Water: A Highly Efficient Synthesis of New 1,2,3,4‐Tetrahydroquinoline Derivatives.
Authors: Zhang Jianheng , Li Chao‐Jun 
Published: May 2010

AbstractFor Abstract see ChemInform Abstract in Full Text.
Regioselective Heteroanellation in Quinazolin‐4‐one Derivatives. Synthesis of 2,5‐Dioxo‐1,2,4,5‐tetrahydropyrrolo[1,2‐a]quinazoline‐3‐carbonitriles.
Authors: Volovenko Yulian M. , Resnyanskaya Elizaveta V. 
Published: May 2010

AbstractFor Abstract see ChemInform Abstract in Full Text.
First Diels—Alder Cycloaddition of N′‐Oxazolyl‐N,N‐dimethylalkylamidines with Electron‐Poor Dienophiles: Characterization of a Diastereoselective Pathway.
Authors: Guillon Jean , Leger Jean‐Michel , Massip Stephane , The Corinne , Vidaillac Celine , Monti Jean‐Pierre , Jarry Christian 
Published: May 2010

AbstractFor Abstract see ChemInform Abstract in Full Text.
New 1,2,3‐Triazolo[1,5]quinoxalines: Synthesis and Binding to Benzodiazepine and Adenosine Receptors. Part 2.
Authors: Biagi Giuliana , Giorgi Irene , Livi Oreste , Scartoni Valerio , Betti Laura , Giannaccini Gino , Trincavelli Maria Letizia 
Published: May 2010

AbstractFor Abstract see ChemInform Abstract in Full Text.
An Efficient Synthesis of 1‐Aryl‐4,6‐diamino‐1,2‐dihydro‐1,3,5‐triazines.
Authors: Saesaengseerung Neungruthai , Vilaivan Tirayut , Thebtaranonth Yodhathai 
Published: May 2010

AbstractFor Abstract see ChemInform Abstract in Full Text.
Synthesis of C‐8 Alkylamino Substituted Pyrrolo[2,1‐c][1,4]benzodiazepines as Potential Anticancer Agents.
Authors: Kamal Ahmed , Laxman N. , Ramesh G. , Srinivas O. , Ramulu P. 
Published: May 2010

AbstractFor Abstract see ChemInform Abstract in Full Text.
Synthesis of Chiral trans‐Fused Pyrano[3,2‐c][2]benzoxocines from D‐Mannose by Regioselective 8‐endo‐Aryl Radical Cyclization.
Authors: Nandi Aniruddha , Chattopadhyay Partha 
Published: May 2010

AbstractFor Abstract see ChemInform Abstract in Full Text.
Synthesis and First Applications of a New Family of Chiral Monophosphine Ligand: 2,5‐Diphenylphospholanes.
Authors: Guillen Frederic , Rivard Michael , Toffano Martial , Legros Jean‐Yves , Daran Jean‐Claude , Fiaud Jean‐Claude 
Published: May 2010

AbstractFor Abstract see ChemInform Abstract in Full Text.
Electron Transfer Driven Transformations of Transition Metal π‐Complexes: Samarium(II) Iodide Mediated Coupling of Fluoroarene‐Cr(CO)3 Complexes with Ketones.
Authors: Schmalz Hans‐Guenther , Kiehl Oliver , Gotov Battsengel 
Published: May 2010

AbstractFor Abstract see ChemInform Abstract in Full Text.
Synthesis and Antiinfluenza Virus Activity of 4‐Guanidino‐7‐substituted Neu5Ac2en Derivatives.
Authors: Honda Takeshi , Masuda Takeshi , Yoshida Shuku , Arai Masami , Kobayashi Yoshiyuki , Yamashita Makoto 
Published: May 2010

AbstractFor Abstract see ChemInform Abstract in Full Text.
Ustalic Acid as a Toxin and Related Compounds from the Mushroom Tricholoma ustale.
Authors: Sano Yosuke , Sayama Kazutoshi , Arimoto Yasushi , Inakuma Takahiro , Kobayashi Kimiko , Koshino Hiroyuki , Kawagishi Hirokazu 
Published: May 2010

AbstractFor Abstract see ChemInform Abstract in Full Text.
Synthesis and Antimycobacterial Activity of 3‐Aryl‐, 3‐Cyclohexyl‐ and 3‐Heteroaryl‐substituted‐2‐(1H(2H)‐benzotriazol‐1 (2)‐yl)prop‐2‐enenitriles, Prop‐2‐enamides and Propenoic Acids. Part 2.
Authors: Sanna Paolo , Carta Antonio , Gherardini Laura , Nikookar Mohammad Esmail Rahbar 
Published: May 2010

AbstractFor Abstract see ChemInform Abstract in Full Text.
Stereoselective Synthesis of the Naturally Occurring Lactones (‐)‐Osmundalactone and (‐)‐Muricatacine Using Ring‐Closing Metathesis.
Authors: Carda Miguel , Rodriguez Santiago , Gonzalez Florenci , Castillo Encarnacion , Villanueva Alicia , Marco J. Alberto 
Published: May 2010

AbstractFor Abstract see ChemInform Abstract in Full Text.
Molecular Toxicological Mechanism of the Lethal Interactions of the New Antiviral Drug, Sorivudine, with 5‐Fluorouracil Prodrugs and Genetic Deficiency of Dihydropyrimidine Dehydrogenase
Authors: Watabe Tadashi , Ogura Kenichiro , Nishiyama Takahito 
Published: May 2010

AbstractFor Abstract see ChemInform Abstract in Full Text.
High‐throughput screening of chemical exchange saturation transfer MR contrast agents
Authors: Liu Guanshu , Gilad Assaf A. , Bulte Jeff W. M. , van Zijl Peter C. M. , McMahon Michael T. 
Published: May 2010

AbstractA new high‐throughput MRI method for screening chemical exchange saturation transfer (CEST) agents is demonstrated, allowing simultaneous testing of multiple samples with minimal attention to sample configuration and shimming of the main magnetic field (B0). This approach, which is applicable to diamagnetic, paramagnetic and liposome CEST agents, employs a set of inexpensive glass or plastic capillary tubes containing CEST agents put together in a cheap plastic tube holder, without the need for liquid between the tubes to reduce magnetic susceptibility effects. In this setup, a reference image of direct water saturation spectra is acquired in order to map the absolute water frequency for each volume element (voxel) in the sample image, followed by an image of saturation transfer spectra to determine the CEST properties. Even though the field over the total sample is very inhomogeneous due to air–tube interfaces, the shape of the direct saturation spectra is not affected, allowing removal of susceptibility shift effects from the CEST data by using the absolute water frequencies from the reference map. As a result, quantitative information such as the mean CEST intensity for each sample can be extracted for multiple CEST agents at once. As an initial application, we demonstrate rapid screening of a library of 16 polypeptides for their CEST properties, but in principle the number of tubes is limited only by the available signal‐noise‐ratio, field of view and gradient strength for imaging. Copyright © 2010 John Wiley & Sons, Ltd.
Systemic therapy of inflammatory breast cancer from high‐dose chemotherapy to targeted therapies
Authors: Viens Patrice , Tarpin Carole , Roche Henri , Bertucci François 
Published: May 2010

AbstractBACKGROUND:Aggressiveness of inflammatory breast cancer (IBC) is related to its metastatic potential. The introduction of primary chemotherapy in the multimodality treatment has dramatically changed the prognosis. However, survival remains poor. Since 1995, innovative systemic therapies have been assessed in France in multicentric clinical trials, initially centered on high‐dose chemotherapy (HDC) with hematopoietic stem cell transplantation (HSCT), and, more recently, on targeted therapies.METHODS:The authors present the rationale and first results of these French studies specifically dedicated to nonmetastastic IBC.RESULTS:More than 380 patients have been included in 5 trials. The first 3 trials enrolled 329 women and concerned HDC (PEGASE 02, 05, 07). PEGASE 02 and PEGASE 05 showed a high pathological complete response rate (30%) after primary sequential HDC, and suggested that more than 4 cycles does not seem to provide any benefit. PEGASE 07 tested adjuvant maintenance chemotherapy after neoadjuvant HDC. Analysis is ongoing. The 2 other trials currently underway combine targeted therapies with conventional‐dose chemotherapy in ERBB2‐negative (Beverly 1 trial; bevacizumab) and ERBB2‐positive (Beverly 2; bevacizumab and trastuzumab) IBC.CONCLUSIONS:HDC with HSCT remains experimental with high pCR rates and which likely benefits to subgroups of patients that remain to be identified. Targeted therapies, such as anti‐ERBB2 and antiangiogenic drugs, are being tested, and should improve survival as demonstrated in non‐IBC. With emerging targeted drugs, there is hope that a cure becomes an achievable goal for more patients. Because of the rarity and the heterogeneity of disease, well‐designed large‐scale collaborative studies are mandatory. Cancer 2010;116(11 suppl):2829–36. © 2010 American Cancer Society.
Targeted therapy in inflammatory breast cancer
Authors: Yamauchi Hideko , Ueno Naoto T. 
Published: May 2010

AbstractDespite the introduction of multimodality treatment approaches, the prognosis of inflammatory breast cancer (IBC) is poor. Recent developments in molecular targeted therapy may be effective against IBC. The authors report the results of a literature review. Trastuzumab and lapatinib, which target human epidermal growth factor receptor 2 (HER‐2), have demonstrated benefit in clinical trials for HER‐2–positive breast cancers. WNT1‐inducible signaling pathway protein 3, Ras homolog gene family member C guanosine triphosphatase, epidermal growth factor receptor (EGFR), and p27kip1 also have been studied as potential targets in IBC. Molecular targets in vasculolymphatic processes (angiogenesis, lymphangiogenesis, and vasculogenesis) have demonstrated greater potential in IBC than in non‐IBC. Although loss of E‐cadherin is a hallmark of epithelial‐to‐mesenchymal transition and may correlate with the promotion of metastasis, paradoxically, E‐cadherin is overexpressed in IBC through an unknown mechanism. On the basis of dissecting the molecular mechanism of the aggressiveness of IBC, the authors currently are investigating whether EGFR may aid in developing innovative targeted therapies. Cancer 2010;116(11 suppl):2758–9. © 2010 American Cancer Society.
Inflammatory breast cancer in Tunisia
Authors: Boussen Hamouda , Bouzaiene Hatem , Ben Hassouna Jamel , Dhiab Tarek , Khomsi Fathi , Benna Farouk , Gamoudi Amor , Mourali Nejib , Hechiche Monia , Rahal Khaled , Levine Paul H. 
Published: May 2010

AbstractInflammatory breast cancer (IBC) is characterized by a peculiar geographic distribution in incidence, being described as more common in Tunisia and the region of North Africa. The authors performed a systematic review of published literature on rapidly progressing breast cancer and IBC in Tunisia and analyzed the evolution in epidemiology, clinical presentation, treatment, and therapeutic results. They collected, analyzed, and compared all the indexed Tunisian articles about rapidly progressing breast cancer and IBC since the 1970s opening of the Institut Salah Azaiz Institute in Tunis. In the 1970s, rapidly progressing breast cancer diagnosis was based on the Poussée Évolutive classification (1‐3). Since the 1990s, IBC diagnosis has been based on the American Joint Committee on Cancer Poussée Évolutive 3/T4d staging. The authors compared the historical data to the most recent publications in terms of epidemiology, clinical features, treatment, and therapeutic results. The most important historical report of rapidly progressing breast cancer concerned 340 patients, representing 58.5% of a cohort of 581 breast cancer patients collected from 1969 to 1974, including 320 (55.2%) with inflammatory signs, 37(6.5%) with Poussée Évolutive 2, and 283 (48.7%) with Poussée Évolutive 3. Subsequent papers have documented a steady decrease in incidence to the current 5% to 7% T4d/IBC. Since the 1970s, Poussée Évolutive in premenopausal woman has increased from 52.5% to 75%; rural predominance has persisted. The 5‐year overall survival reached 28% by the year 2000. The authors' analysis demonstrated a trend of decreasing incidence of IBC diagnoses from 50% to presently <10%, probably related to a combination of factors, including the use of more stringent criteria (Poussée Évolutive 3/T4d) for IBC diagnosis and an improvement in the socioeconomic level of Tunisia. Cancer 2010;116(11 suppl):2730–5. © 2010 American Cancer Society.
Is there a role for mammary stem cells in inflammatory breast carcinoma?
Authors: Van Laere Steven , Limame Ridha , Van Marck Eric A. , Vermeulen Peter B. , Dirix Luc Y. 
Published: May 2010

AbstractStem cells are pluripotent cells, with a large replicative potential, which perform normal physiological functions such as tissue renewal and damage repair. However, because of their long lifespan and high replicative potential, stem cells are ideal targets to accumulate multiple mutations. Therefore, they can be regarded as being responsible for the initiation of tumor formation. In the past, numerous studies have shown that the presence of an elaborate stem cell compartment within a tumor is associated with aggressive tumor cell behavior, frequent formation of metastases, resistance to therapy, and poor patient survival. From this perspective, tumors from patients with inflammatory breast cancer (IBC), an aggressive breast cancer subtype with a dismal clinical course, are most likely to be associated with stem cell biology. To date, this hypothesis is corroborated by evidence resulting from in vitro and in vivo experiments. Both gene and microRNA expression profiles highlighted several stem cell‐specific signal transduction pathways that are hyperactivated in IBC. Also, these stem cell‐specific signal transduction pathways seem to converge in the activation of nuclear factor‐kappa B, a molecular hallmark of IBC, and induction of epithelial‐to‐mesenchymal transition. Recently, the latter mechanism was identified as a prerequisite for the induction of stem cell characteristics in breast cancer cells. Cancer 2010;116(11 suppl):2794–805. © 2010 American Cancer Society.
Lp theory for the multidimensional aggregation equation
Authors: Bertozzi Andrea L. , Laurent Thomas , Rosado Jesús 
Published: May 2010

AbstractWe consider well‐posedness of the aggregation equation ∂tu + div(uv) = 0, v = −▿K * u with initial data in
\input amssym ${\cal P}_2 {\rm (\Bbb R}^d {\rm )} \cap L^p ({\Bbb R}^d )$
in dimensions 2 and higher. We consider radially symmetric kernels where the singularity at the origin is of order |x|α, α > 2 − d, and prove local well‐posedness in \input amssym ${\cal P}_2 { (\Bbb R}^d {\rm )} \cap L^p ({\Bbb R}^d )$
for sufficiently large p < ps. In the special case of K(x) = |x|, the exponent ps = d/(d = 1) is sharp for local well‐posedness in that solutions can instantaneously concentrate mass for initial data in \input amssym ${\cal P}_2 { (\Bbb R}^d {\rm )} \cap L^p ({\Bbb R}^d )$
with p < ps. We also give an Osgood condition on the potential K(x) that guarantees global existence and uniqueness in \input amssym ${\cal P}_2 { (\Bbb R}^d {\rm )} \cap L^p ({\Bbb R}^d )$. © 2010 Wiley Periodicals, Inc.
Specific isoforms of drosophila shroom define spatial requirements for the induction of apical constriction
Authors: Bolinger Cory , Zasadil Lauren , Rizaldy Ryan , Hildebrand Jeffrey D. 
Published: May 2010

AbstractVertebrate Shroom proteins define cytoskeletal organization and cellular architecture by binding directly to F‐actin and Rho‐kinase and spatially regulating the activity of nonmuscle myosin II (myosin II). Here, we report characterization and gain‐of‐function analysis of Drosophila Shroom. The dShrm locus expresses at least two protein isoforms, dShrmA and dShrmB, which localize to adherens junctions and the apical membrane, respectively. dShrmA and dShrmB exhibit differing abilities to induce apical constriction that are based on their subcellular distribution and the subsequent assembly of spatially and organizationally distinct actomyosin networks that are dependent on the ability to engage Rho‐kinase and the activity of myosin II. These data show that the differential subcellular distribution of naturally occurring isoforms of Shroom proteins can define both the position and organization of actomyosin networks in vivo. We further hypothesize that differentially positioned contractile arrays have distinct effects on cellular morphologies and behaviors. Developmental Dynamics 239:2078–2093, 2010. © 2010 Wiley‐Liss, Inc.
Brain tissue volume changes following weight gain in adults with anorexia nervosa
Authors: Roberto Christina A. , Mayer Laurel E. S. , Brickman Adam M. , Barnes Anna , Muraskin Jordan , Yeung Lok‐Kin , Steffener Jason , Sy Melissa , Hirsch Joy , Stern Yaakov , Walsh B. Timothy 
Published: May 2010

AbstractObjective:To measure brain volume deficits among underweight patients with anorexia nervosa (AN) compared to control participants and evaluate the reversibility of these deficits with short‐term weight restoration.Method:Brain volume changes in gray matter (GM), white matter (WM), and cerebrospinal fluid (CSF) were examined in 32 adult women with AN and compared to 21, age and body mass index‐range matched control women.Results:Patients with AN had a significant increase in GM (p = .006, η2 = 0.14) and WM volume (p = .001, η2 = 0.19) following weight restoration. Patients on average had lower levels of GM at low weight (647.63 ± 62.07 ml) compared to controls (679.93 ± 53.31 ml), which increased with weight restoration (662.64 ± 69.71 ml), but did not fully normalize.Discussion:This study suggests that underweight adult patients with AN have reduced GM and WM volumes that increase with short‐term weight restoration. © 2010 by Wiley Periodicals, Inc. (Int J Eat Disord 2011; 44:406–411)