bluuebunny/crossref_metadata_2025_split huggingface dataset:
Basin architecture and growth folding of the NW Zagros early foreland basin during the Late Cretaceous and early Tertiary
Authors: Saura Eduard , Vergés Jaume , Homke Stéphane , Blanc Eric , Serra-Kiel Josep , Bernaola Gilen , Casciello Emilio , Fernández Naiara , Romaire Indiana , Casini Giulio , Embry Jean Christophe , Sharp Ian R. , Hunt David W. 
Published: January 2011

Abstract:

We present and use the chronostratigraphy of 13 field logs and detailed mapping to constrain the evolution of the early Zagros foreland basin, in NW Iran. Large foraminifera, calcareous nannofossil, palynological and
87
Sr/
86
Sr analysis supplied ages indicating a Campanian–early Eocene age of the basin infill, which is characterizd by a diachronous, southwestward migrating, shallowing upwards, mixed clastic–carbonate succession. Growth synclines and local palaeoslope variations indicate syndepositional folding from Maastrichtian to Eocene time and suggest forelandward migration of the deformation front. We also illustrate the basin architecture with a synthetic stratigraphic transect. From internal to external areas, time lines cross the formation boundaries from continental Kashkan red beds to Taleh Zang mixed clastic–carbonate platforms, Amiran slope deposits and basinal Gurpi–Pabdeh shales and marls. The foreland basin depocentres show a progressive migration from the Campanian to Eocene (
c
. 83–52.7 Ma), with rates of
c
. 2.4 mm a
−1
during the early–middle Palaeocene (
c
. 65.5–58.7 Ma) increasing to
c
. 6 mm a
−1
during the late Palaeocene–earliest Eocene (
c
. 58.7–52.8 Ma). Coeval subsidence remained at
c
. 0.27 mm a
−1
during the first 12.7 Ma and decreased to
c
. 0.16 mm a
−1
during the last 4.2 Ma of basin filling. Finally, we integrate our results with published large-scale maps and discuss their implications in the context of the Zagros orogeny.

Supplementary material:

Tables with dating results are available at
http://www.geolsoc.org.uk/SUP18439
.
Terrane transfer during the Caledonian orogeny: Baltican affinities of the Liverpool Land Eclogite Terrane in East Greenland
Authors: Augland Lars Eivind , Andresen Arild , Corfu Fernando 
Published: January 2011

Abstract:
The Liverpool Land basement horst, East Greenland, comprises two allochthonous Caledonian terranes with very different tectonomagmatic and metamorphic histories, separated by the composite Gubbedalen Shear Zone. The Liverpool Land Eclogite Terrane in the footwall consists of orthogneiss formed at 1645–1640 Ma, affected by eclogite-facies metamorphism at 400 Ma and subsequently migmatized and intruded by granites at 388–385 Ma. The Liverpool Land Eclogite Terrane contrasts with the upper plate, which consists of arc-related Late Ordovician to Early Silurian magmatic rocks and was not affected by the Devonian metamorphism seen in the lower plate. Conversely, Ordovician–Silurian rocks are absent from the lower plate. Mesoproterozoic protolith ages, Early Devonian high-pressure metamorphism, and the occurrence of garnet peridotite distinguish the Liverpool Land Eclogite Terrane from all other terranes in East Greenland, including the large North East Greenland Eclogite Province, whereas these features are characteristic for the Western Gneiss Region in Norway. These observations indicate that the Liverpool Land Eclogite Terrane is exotic with respect to Laurentia and a Baltican origin seems likely. The amalgamation of the Baltican crustal slice with Laurentia probably occurred by imbrication of subducted Baltican crust in a bulk transpressional setting.
Sector collapse of mud volcanoes, Azerbaijan
Authors: Roberts Katie S. , Stewart Simon A. , Davies Richard J. , Evans Robert J. 
Published: January 2011

Abstract:

Field data collected from mud volcanoes in Azerbaijan are used to describe a process in mud volcano development that involves portions of the constructional edifices collapsing outwards in ‘thin-skinned' slides. These events create kilometre-scale scarps that are tens of metres in height, arcuate in plan view, elongate and facing downdip. Similar morphological features occur on igneous volcanoes and have been described as ‘sector collapse' structures. The largest sector collapses in igneous volcanoes involve some 10
12
tons of mobilized material; equivalent structures in mud volcanoes are several orders of magnitude smaller. We employ a shape parameter that can be utilized in field and satellite-based mapping, to distinguish between slope failure and eruptive deposits. Three mud volcanoes with kilometre-scale sector collapses are described and controlling mechanisms are reviewed. The updip domains of these collapses are characterized by fluid escape, showing that there is also linkage to deeper mud volcano structure. The observations are reconciled in a model consisting of a deflating mud chamber that triggers thin-skinned sector collapse. The updip domain of the sector collapse is localized above a deep-seated zone of volume loss and the downdip domain of the collapse runs down the edifice flank onto the surrounding plain.
Confounding Effects of Hormone Replacement Therapy in Protein Biomarker Studies
Authors: Pitteri Sharon J. , Hanash Samir M. 
Published: January 2011

Abstract
Background: We have recently investigated effects of hormone replacement therapy (HRT) on the serum proteome, and found a high proportion of proteins with altered levels associated with oral estrogen and/or estrogen plus progesterone treatment. Given this finding, we have investigated the extent to which exposure to HRT may have a confounding effect in the assessment of circulating proteins as cancer biomarkers.
Methods: We utilize mass spectrometry data collected from the HRT serum proteome studies to estimate the overall effect of postmenopausal hormone therapy on candidate ovarian cancer biomarkers that have been previously reported.
Results: Levels of approximately half of the proteins reported as potential ovarian cancer biomarkers were found to be affected by HRT. The impact of HRT on levels of insulin-like growth factor and inhibin protein families was found to be substantial.
Conclusions: We conclude that the potential confounding effect of HRT and other types of exposures should be taken into consideration in cancer biomarker study design.
Impact: HRT significantly affects the serum proteome and should be taken into account as part of biomarker study design and data analysis. Cancer Epidemiol Biomarkers Prev; 20(1); 134–9. ©2011 AACR.
Validation of Genome-Wide Prostate Cancer Associations in Men of African Descent
Authors: Chang Bao-Li , Spangler Elaine , Gallagher Stephen , Haiman Christopher A. , Henderson Brian , Isaacs William , Benford Marnita L. , Kidd LaCreis R. , Cooney Kathleen , Strom Sara , Ingles Sue Ann , Stern Mariana C. , Corral Roman , Joshi Amit D. , Xu Jianfeng , Giri Veda N. , Rybicki Benjamin , Neslund-Dudas Christine , Kibel Adam S. , Thompson Ian M. , Leach Robin J. , Ostrander Elaine A. , Stanford Janet L. , Witte John , Casey Graham , Eeles Rosalind , Hsing Ann W. , Chanock Stephen , Hu Jennifer J. , John Esther M. , Park Jong , Stefflova Klara , Zeigler-Johnson Charnita , Rebbeck Timothy R. 
Published: January 2011

Abstract
Background: Genome-wide association studies (GWAS) have identified numerous prostate cancer susceptibility alleles, but these loci have been identified primarily in men of European descent. There is limited information about the role of these loci in men of African descent.
Methods: We identified 7,788 prostate cancer cases and controls with genotype data for 47 GWAS-identified loci.
Results: We identified significant associations for SNP rs10486567 at JAZF1, rs10993994 at MSMB, rs12418451 and rs7931342 at 11q13, and rs5945572 and rs5945619 at NUDT10/11. These associations were in the same direction and of similar magnitude as those reported in men of European descent. Significance was attained at all reported prostate cancer susceptibility regions at chromosome 8q24, including associations reaching genome-wide significance in region 2.
Conclusion: We have validated in men of African descent the associations at some, but not all, prostate cancer susceptibility loci originally identified in European descent populations. This may be due to the heterogeneity in genetic etiology or in the pattern of genetic variation across populations.
Impact: The genetic etiology of prostate cancer in men of African descent differs from that of men of European descent. Cancer Epidemiol Biomarkers Prev; 20(1); 23–32. ©2011 AACR.
Feasibility of Identifying Pancreatic Cancer Based on Serum Metabolomics
Authors: Bathe Oliver F. , Shaykhutdinov Rustem , Kopciuk Karen , Weljie Aalim M. , McKay Andrew , Sutherland Francis R. , Dixon Elijah , Dunse Nicole , Sotiropoulos Dina , Vogel Hans J. 
Published: January 2011

AbstractBackground: We postulated that the abundance of various metabolites in blood would facilitate the diagnosis of pancreatic and biliary lesions, which could potentially prevent unnecessary surgery.Methods: Serum samples from patients with benign hepatobiliary disease (n = 43) and from patients with pancreatic cancer (n = 56) were examined by 1H NMR spectroscopy to quantify 58 unique metabolites. Data were analyzed by “targeted profiling” followed by supervised pattern recognition and orthogonal partial least-squares discriminant analysis (O-PLS-DA) of the most significant metabolites, which enables comparison of the whole sample spectrum between groups.Results: The metabolomic profile of patients with pancreatic cancer was significantly different from that of patients with benign disease (AUROC, area under the ROC curve, = 0.8372). Overt diabetes mellitus (DM) was identified as a possible confounding factor in the pancreatic cancer group. Thus, diabetics were excluded from further analysis. In this more homogeneous pancreatic cancer group, compared with benign cases, serum concentrations of glutamate and glucose were most elevated on multivariate analysis. In benign cases, creatine and glutamine were most abundant. To examine the usefulness of this test, a comparison was made to age- and gender-matched controls with benign lesions that mimic cancer, controlling also for presence of jaundice and diabetes (n = 14 per group). The metabolic profile in patients with pancreatic cancer remained distinguishable from patients with benign pancreatic lesions (AUROC = 0.8308).Conclusions: The serum metabolomic profile may be useful for distinguishing benign from malignant pancreatic lesions.Impact: Further studies will be required to study the effects of jaundice and diabetes. A more comprehensive metabolomic profile will be evaluated using mass spectrometry. Cancer Epidemiol Biomarkers Prev; 20(1); 140–7. ©2010 AACR.
Epigenetic Deregulation Across Chromosome 2q14.2 Differentiates Normal from Prostate Cancer and Provides a Regional Panel of Novel DNA Methylation Cancer Biomarkers
Authors: Devaney James , Stirzaker Clare , Qu Wenjia , Song Jenny Z. , Statham Aaron L. , Patterson Kate I. , Horvath Lisa G. , Tabor Bruce , Coolen Marcel W. , Hulf Toby , Kench James G. , Henshall Susan M. , Pe Benito Ruth , Haynes Anne-Maree , Mayor Regina , Peinado Miguel A. , Sutherland Robert L. , Clark Susan J. 
Published: January 2011

Abstract
Background: Previously, we showed that gene suppression commonly occurs across chromosome 2q14.2 in colorectal cancer, through a process of long-range epigenetic silencing (LRES), involving a combination of DNA methylation and repressive histone modifications. We now investigate whether LRES also occurs in prostate cancer across this 4-Mb region and whether differential DNA methylation of 2q14.2 genes could provide a regional panel of prostate cancer biomarkers.
Methods: We used highly sensitive DNA methylation headloop PCR assays that can detect 10 to 25 pg of methylated DNA with a specificity of at least 1:1,000, and chromatin immunoprecipitation assays to investigate regional epigenetic remodeling across 2q14.2 in prostate cancer, in a cohort of 195 primary prostate tumors and 90 matched normal controls.
Results: Prostate cancer cells exhibit concordant deacetylation and methylation of histone H3 Lysine 9 (H3K9Ac and H3K9me2, respectively), and localized DNA hypermethylation of EN1, SCTR, and INHBB and corresponding loss of H3K27me3. EN1 and SCTR were frequently methylated (65% and 53%, respectively), whereas INHBB was less frequently methylated.
Conclusions: Consistent with LRES in colorectal cancer, we found regional epigenetic remodeling across 2q14.2 in prostate cancer. Concordant methylation of EN1 and SCTR was able to differentiate cancer from normal (P &lt; 0.0001) and improved the diagnostic specificity of GSTP1 methylation for prostate cancer detection by 26%.
Impact: For the first time we show that DNA methylation of EN1 and SCTR promoters provide potential novel biomarkers for prostate cancer detection and in combination with GSTP1 methylation can add increased specificity and sensitivity to improve diagnostic potential. Cancer Epidemiol Biomarkers Prev; 20(1); 148–59. ©2011 AACR.
Allelic Imbalance in BRCA1 and BRCA2 Gene Expression and Familial Ovarian Cancer
Authors: Shen Jie , Medico Leo , Zhao Hua 
Published: January 2011

Abstract
Background: Family history is the strongest risk factor for ovarian cancer. Recent evidence suggests that unidentified BRCA1/2 variations or other genetic events may contribute to familial ovarian cancers. Allelic imbalance (AI) of BRCA1/2 expression, a result of a significant decrease in the ratios between the expression from one allele of BRCA1/2 and the other allele, has been observed in breast cancer. The AI of BRCA1/2 expression could decrease the level of transcripts and thus contribute to an increased susceptibility of developing familial ovarian cancer.
Methods: To test this hypothesis, we applied a quantitative, allelic-specific, real-time PCR method to survey the levels of AI in BRCA1/2 in lymphoblastoid cell lines (LCL) from 126 familial ovarian cancer patients who are noncarriers of any known BRCA1/2 and MLH/MSH mutations and 118 cancer-free relative controls.
Results: The AI ratios of BRCA1, but not BRCA2, in the LCLs from familial ovarian cancer patients were found to be significantly increased as compared with family controls (BRCA1: 0.463 ± 0.054 vs. 0.405 ± 0.111, P = 0.0007; BRCA2: 0.325 ± 0.124 vs. 0.302 ± 0.118, P = 0.328). Using the cutoff point of 0.458 identified from the receiver operating characteristic (ROC) analysis, higher levels of AI were associated with a 4.22-fold increased risk of familial ovarian cancer (95% CI: 1.60–11.16). In further analysis, we observed that levels of AI were negatively significantly correlated with the age of familial ovarian cancer diagnosis (ρ = −0.469, P &lt; 0.001).
Conclusion: Taken together, our data suggest that AI affecting BRCA1 may contribute to familial ovarian cancer. Cancer Epidemiol Biomarkers Prev; 20(1); 50–6. ©2011 AACR.
Infection with Hepatitis B and C Viruses and Risk of Lymphoid Malignancies in the European Prospective Investigation into Cancer and Nutrition (EPIC)
Authors: Franceschi Silvia , Lise Mauro , Trépo Christian , Berthillon Pascale , Chuang Shu-Chun , Nieters Alexandra , Travis Ruth C. , Vermeulen Roel , Overvad Kim , Tjønneland Anne , Olsen Anja , Bergmann Manuela M. , Boeing Heiner , Kaaks Rudolf , Becker Nikolaus , Trichopoulou Antonia , Lagiou Pagona , Bamia Christina , Palli Domenico , Sieri Sabina , Panico Salvatore , Tumino Rosario , Sacerdote Carlotta , Bueno-de-Mesquita Bas , Peeters Petra H.M. , Rodríguez Laudina , Barroso Leila Luján , Dorronsoro Miren , Sánchez María-José , Navarro Carmen , Barricarte Aurelio , Regnér Sara , Borgquist Signe , Melin Beatrice , Hallmans Göran , Khaw Kay-Tee , Wareham Nick , Rinaldi Sabina , Hainaut Pierre , Riboli Elio , Vineis Paolo 
Published: January 2011

Abstract
Background: Case–control studies suggested a moderate, but consistent, association of hepatitis C virus (HCV) infection with lymphoid tissue malignancies, especially non–Hodgkin lymphoma (NHL). More limited data suggested that hepatitis B virus (HBV) infection might also be associated with NHL. However, prospective studies on the topic are few.
Methods: A nested case–control study was conducted in eight countries participating in the EPIC prospective study. Seven hundred thirty-nine incident cases of NHL, 238 multiple myeloma (MM), and 46 Hodgkin lymphoma (HL) were matched with 2,028 controls. Seropositivity to anti-HCV, anti-HBc, and HBsAg was evaluated and conditional logistic regression was used to estimate odds ratios (OR) and corresponding 95% confidence intervals (CI) for NHL, MM, or HL, and their combination.
Results: Anti-HCV seropositivity among controls in different countries ranged from 0% to 5.3%; HBsAg from 0% to 2.7%; and anti-HBc from 1.9% to 45.9%. Similar nonsignificant associations were found with seropositivity to HBsAg for NHL (OR = 1.78; 95% CI: 0.78–4.04), MM (OR = 4.00; 95% CI: 1.00–16.0), and HL (OR = 2.00; 95% CI: 0.13–32.0). The association between HBsAg and the combination of NHL, MM, and HL (OR = 2.21; 95% CI: 1.12–4.33) was similar for cancer diagnosed less than 3 and 3 or more years after blood collection. No significant association was found between anti-HCV and NHL, MM, or HL risk, but the corresponding CIs were very broad.
Conclusions: Chronic HBV infection may increase the risk of lymphoid malignancies among healthy European volunteers.
Impact: Treatment directed at control of HBV infection should be evaluated in HBsAg-seropositive patients with lymphoid tissue malignancies. Cancer Epidemiol Biomarkers Prev; 20(1); 208–14. ©2011 AACR.
Efficacy of Exercise Interventions in Modulating Cancer-Related Fatigue among Adult Cancer Survivors: A Meta-Analysis
Authors: Brown Justin C. , Huedo-Medina Tania B. , Pescatello Linda S. , Pescatello Shannon M. , Ferrer Rebecca A. , Johnson Blair T. 
Published: January 2011

Abstract
Background: The purpose of this meta-analysis was to explore the efficacy of exercise as a nonpharmacologic intervention to reduce cancer-related fatigue (CRF) among adult cancer survivors. We also investigated how different components of the exercise prescription (Ex Rx), methodologic considerations, and subject characteristics modulate CRF.
Methods: A systematic search for randomized controlled trials was conducted using words related to cancer, exercise, and fatigue.
Results: In total, 44 studies with 48 interventions qualified, including 3,254 participants of varying cancer types, stages of diagnosis, treatments, and exercise interventions. Cancer survivors in exercise interventions reduced their CRF levels to a greater extent than usual care controls, d+ = 0.31 (95% CI = 0.22–0.40), an effect that appeared to generalize across several types of cancer. CRF levels improved in direct proportion to the intensity of resistance exercise (β = 0.60, P = 0.01), a pattern that was stronger in higher quality studies (β = 0.23, P &lt; 0.05). CRF levels also reduced to a greater extent when interventions were theoretically driven (β = 0.48, P &lt; 0.001) or cancer survivors were older (β = 0.24, P = 0.04).
Conclusions: Exercise reduced CRF especially in programs that involved moderate-intensity, resistance exercise among older cancer survivors and that were guided by theory.
Impact: Our results indicate exercise interventions for adult cancer survivors should be multi-dimensional and individualized according to health outcome and cancer type. Cancer Epidemiol Biomarkers Prev; 20(1); 123–33. ©2011 AACR.
A Role of Sphingosine Kinase 1 in Head and Neck Carcinogenesis
Authors: Shirai Keisuke , Kaneshiro Tatsuya , Wada Masayuki , Furuya Hideki , Bielawski Jacek , Hannun Yusuf A. , Obeid Lina M. , Ogretmen Besim , Kawamori Toshihiko 
Published: January 2011

Abstract
It is important to identify novel and effective targets for cancer prevention and therapy against head and neck squamous cell carcinoma (HNSCC), one of the most lethal cancers. Accumulating evidence suggests that the bioactive sphingolipids, such as sphingosine-1-phosphate (S1P) and its generating enzyme, sphingosine kinase 1 (SphK1) play pivotal roles in several important biological functions including promoting tumor growth and carcinogenesis. However, roles of SphK1/S1P in HNSCC development and/or progression have not been defined previously. Therefore, in this study, we first analyzed the expression of SphK1 in human HNSCC tumor samples and normal head & neck tissues (n = 78 and 17, respectively) using immunohistochemistry. The data showed that SphK1 is overexpressed in all of the HNSCC tumors tested (stages I–IV). We next investigated whether SphK1 is necessary for HNSCC development. To define the role of SphK1/S1P in HNSCC development, we utilized 4-nitroquinoline-1-oxide (4-NQO)-induced HNSCC model in wild-type mice compared with SphK1−/− knockout (KO) mice. Remarkably, we found that the genetic loss of SphK1, which reduced S1P generation, significantly prevented 4-NQO–induced HNSCC carcinogenesis, with decreased tumor incidence, multiplicity, and volume when compared with controls. Moreover, our data indicated that prevention of 4-NQO–induced HNSCC development in SphK1−/− KO mice might be associated with decreased cell proliferation, increased levels of cleaved (active) caspase 3, and downregulation of phospho (active) AKT expression. Thus, these novel data suggest that SphK1/S1P signaling may play important roles in HNSCC carcinogenesis, and that targeting SphK1/S1P might provide a novel strategy for chemoprevention and treatment against HNSCC. Cancer Prev Res; 4(3); 454–62. ©2011 AACR.
Valve Configuration Determines Long-Term Results After Repair of the Bicuspid Aortic Valve
Authors: Aicher Diana , Kunihara Takashi , Abou Issa Omar , Brittner Brigitte , Gräber Stefan , Schäfers Hans-Joachim 
Published: January 2011

Background—
Reconstruction of the regurgitant bicuspid aortic valve has been performed for >10 years, but there is limited information on long-term results. We analyzed our results to determine the predictors of suboptimal outcome.

Methods and Results—
Between November 1995 and December 2008, 316 patients (age, 49±14 years; male, 268) underwent reconstruction of a regurgitant bicuspid aortic valve. Intraoperative assessment included extent of fusion, root dimensions, circumferential orientation of the 2 normal commissures (>160°, ≤160°), and effective height after repair. Cusp pathology was treated by central plication (n=277), triangular resection (n=138), or pericardial patch (n=94). Root dilatation was treated by subcommissural plication (n=100), root remodeling (n=122), or valve reimplantation (n=2). All patients were followed up echocardiographically (cumulative follow-up, 1253 years; mean, 4±3.1 years). Clinical and morphological parameters were analyzed for correlation with 10-year freedom from reoperation with the Cox proportional hazards model. Hospital mortality was 0.63%; survival was 92% at 10 years. Freedom from reoperation at 5 and 10 years was 88% and 81%; freedom from valve replacement, 95% and 84%. By univariable analysis, statistically significant predictors of reoperation were age (hazard ratio [HR]=0.97), aortoventricular diameter (HR=1.24), effective height (HR=0.76), commissural orientation (HR=0.95), use of a pericardial patch (HR=7.63), no root replacement (HR=3.80), subcommissural plication (HR=2.07), and preoperative aortic regurgitation grade 3 or greater. By multivariable analysis, statistically significant predictors for reoperation were age (HR=0.96), aortoventricular diameter (HR=1.30), effective height (HR=0.74), commissural orientation (HR=0.96), and use of a pericardial patch (HR=5.16).

Conclusions—
Reconstruction of bicuspid aortic valve can be performed reproducibly with good early results. Recurrence and progression of regurgitation, however, may occur, depending primarily on anatomic features of the valve.