bluuebunny/crossref_metadata_2025_split huggingface dataset:
LC–MS analysis of polar and highly polar organic pollutants in Barcelona urban groundwater using orthogonal LC separation modes
Authors: Labad Francesc , Pérez Sandra 
Published: April 2024

AbstractGroundwater samples may contain thousands of organic pollutants from infiltration of surface water, sewer leakages, and to a minor extent from public water supply network losses. Polar (0 < log D <  − 2.0) and very polar substances (log D <  − 2.0) have been largely beyond the scope of applied analytical methodologies in environmental monitoring because of challenges related to their extraction from the sample and subsequent chromatographic separation. In this study, we developed an analytical workflow for 96 pollutants covering a broad polarity range, including pharmaceuticals, industrial chemicals, and artificial sweeteners, potentially seeping through the soil in urban areas. The Besos aquifer located at the Northern-eastern edge of the city of Barcelona was chosen as a study area due to the deterioration of the quality of the aquifers over the past years and the proven presence of numerous pollutants. The methodology consisted of vacuum-assisted evaporation (VAE) followed by chromatographic separation of the sample on two columns with orthogonal retention mechanisms, namely, an HSS T3 column (modified C18) and a BEH amide column (HILIC). The analytes were detected by high-resolution mass spectrometry on a Q Exactive Orbitrap system in data-independent acquisition mode. Taking into consideration the retention as well as the peak shape, a Quality Score (QS) was assigned for each analyte to evaluate the quality of each chromatographic peak of each compound. While 67 compounds, including 19 polar and 48 moderately polar, were satisfactorily retained on an HSS T3, 29 compounds, including 14 highly polar, 14 polar, and one moderately polar, were analyzed in the BEH amide column. The optimized methodology was applied for the analysis of 89 out of 96 validated contaminants with satisfactory recoveries in samples collected from seven wells, providing low LODs (0.02 to 0.45 ng L−1) and LOQs (0.06 to 1.34 ng L−1). A number of highly polar and polar compounds not previously reported to occur in GW, including artificial sweeteners, pharmaceuticals, and industrial chemicals, were detected at concentrations as high as few $$\mu$$
μ
g L−1.
Mitochondrial dysfunction in long COVID: mechanisms, consequences, and potential therapeutic approaches
Authors: Molnar Tihamer , Lehoczki Andrea , Fekete Monika , Varnai Reka , Zavori Laszlo , Erdo-Bonyar Szabina , Simon Diana , Berki Tímea , Csecsei Peter , Ezer Erzsebet 
Published: April 2024

AbstractThe COVID-19 pandemic, caused by the SARS-CoV-2 virus, has introduced the medical community to the phenomenon of long COVID, a condition characterized by persistent symptoms following the resolution of the acute phase of infection. Among the myriad of symptoms reported by long COVID sufferers, chronic fatigue, cognitive disturbances, and exercise intolerance are predominant, suggesting systemic alterations beyond the initial viral pathology. Emerging evidence has pointed to mitochondrial dysfunction as a potential underpinning mechanism contributing to the persistence and diversity of long COVID symptoms. This review aims to synthesize current findings related to mitochondrial dysfunction in long COVID, exploring its implications for cellular energy deficits, oxidative stress, immune dysregulation, metabolic disturbances, and endothelial dysfunction. Through a comprehensive analysis of the literature, we highlight the significance of mitochondrial health in the pathophysiology of long COVID, drawing parallels with similar clinical syndromes linked to post-infectious states in other diseases where mitochondrial impairment has been implicated. We discuss potential therapeutic strategies targeting mitochondrial function, including pharmacological interventions, lifestyle modifications, exercise, and dietary approaches, and emphasize the need for further research and collaborative efforts to advance our understanding and management of long COVID. This review underscores the critical role of mitochondrial dysfunction in long COVID and calls for a multidisciplinary approach to address the gaps in our knowledge and treatment options for those affected by this condition.
Social hotspots in the automotive industry’s aluminum value chains—combining primary and generic data
Authors: Luthin Anna , Knacksterdt Jan , Traverso Marzia 
Published: April 2024

Abstract
Purpose
The automotive industry and its suppliers have been facing increasing challenges in the sustainable sourcing of raw materials on environmental and social levels. To identify social risks in the value chain of aluminum in the automotive sector, this study aimed to examine how a generic hotspot analysis based on S-LCA can be conducted and support the reporting according to new legislative requirements such as the German Act on Corporate Due Diligence Obligations in Supply Chains.

Methods
This study investigated the social risks in the supply chains of two selected aluminum components of an aluminum company using a generic social hotspot analysis based on the UNEP Guidelines for Social Life Cycle Assessment of Products and Organizations 2020. The study employed the generic PSILCA© database and different additional indicators for the assessment. The UNEP Guidelines 2020 used in combination with the associated methodological sheets were beneficial in structuring the procedure within the social hotspot analysis. They gave the inexperienced user a guide, which led to the results presented in this work.

Results and discussion
A high number of social hotspots in upstream processes outside Europe across the different investigated indicators for both supply chains assessed were detected. Most social risks were identified in Guinea, as well as in a European and an Asian Country in the stakeholder categories “Workers” and “Local community.” Especially, the alloy element production in the Asian Country and the bauxite mining in Guinea showed an above-average number of social hotspots. The implementation of the work was associated with an enormous effort in information collection about the supply chains to be investigated and depended on the direct suppliers’ willingness to contribute. The need for a safe and supporting environment for suppliers to enhance transparency was identified.

Conclusions
Combining generic and company data to conduct a social hotspot assessment (e.g., using PSILCA©) to meet legislative requirements proved to be a suitable approach for complex supply chains such as the automotive one. Despite this, limitations of the PSILCA© database and potential for improvement were acknowledged regarding industry-wide social assessments of supply chains. Additionally, the study serves as an application example of the UNEP Guidelines 2020 and the activity variables for science in practice. Further development and standardization of social indicators and activity variables for impact measurement were identified as a research priority.
The Longitudinal Association Between Peer Victimization and Problematic Social Media Use Among Chinese College Students: Testing a Moderated Mediation Model
Authors: Dou Kai , Wang Meng-Li , Li Yan-Yu , Yuan Xue-Qing , Wang Lin-Xin 
Published: April 2024

AbstractPeer victimization serves as a risk factor contributing to emotional and behavioral problems among college students. However, limited research has investigated the longitudinal association between peer victimization and problematic social media use (PSMU), as well as its underlying mechanism. Drawing upon the compensatory internet use theory, self-determination theory, and the stress-buffering model, we assumed that fear of missing out (FoMO) could potentially serve as a mediating factor in the relationship between peer victimization and PSMU, while school belongingness may act as a moderator for these direct and indirect associations. A total of 553 Chinese college students (Mage = 21.87, SD = 1.07) were recruited to participate in a three-wave longitudinal study (6 months apart) and completed questionnaires assessing peer victimization (T1), school belongingness (T1), FoMO (T2), and PSMU (T3). With a moderated mediation model, the results indicated the following: (1) Controlling for demographic variables, T1 peer victimization was positively and significantly associated with T3 PSMU; (2) T1 peer victimization also influenced T3 PSMU indirectly by increasing both two dimensions of T2 FoMO; (3) T1 school belongingness significantly moderated the mediating effect of T2 fear of missing social opportunities. Specifically, the indirect effect of peer victimization on PSMU via fear of missing social opportunities was found to be more pronounced when the level of school belongingness was lower. These findings are of great value in extending the studies regarding the multi-systematical risk factors causing PSMU and providing the scientific reference for the prevention and intervention of PSMU among Chinese college students.
Imaging evaluation and volumetric measurement of the space surrounding the diploic veins
Authors: Nakamichi Rei , Taoka Toshiaki , Ito Rintaro , Yoshida Tadao , Sone Michihiko , Naganawa Shinji 
Published: April 2024

Abstract
Purpose
The diploic veins have been suggested to be involved in the excretion of cerebrospinal fluid and intracranial waste products; however, to date, there have been no reports evaluating the space surrounding the diploic veins. Therefore, we aimed to visualize the distribution of gadolinium-based contrast agent (GBCA) in the space surrounding the diploic veins and to evaluate the spatial characteristics.

Materials and methods
Ninety-eight participants (aged 14–84 years) were scanned 4 h after intravenous GBCA injection at Nagoya University Hospital between April 2021 and December 2022. The volume of the space surrounding the diploic veins where the GBCA was distributed was measured using contrast-enhanced T1-weighted images with the application of three-axis motion-sensitized driven equilibrium. The parasagittal dura (PSD) volume adjacent to the superior sagittal sinus was also measured using the same images. Both volumes were corrected for intracranial volume. The correlation between age and the corrected volume was examined using Spearman’s rank correlation coefficient; the relationship between the corrected volume and sex was assessed using the Mann–Whitney U test.

Results
A significant weak negative correlation was observed between the volume of the space surrounding the diploic veins and age (r = −0.330, p < 0.001). Furthermore, there was a significant weak positive correlation between the PSD volume and age (r = 0.385, p < 0.001). Both volumes were significantly greater in men than in women. There was no correlation between the volume of the space surrounding the diploic veins and the volume of the PSD.

Conclusion
The volume of the space surrounding the diploic veins was measurable and, in contrast to the volume of the PSD, was greater in younger participants. This space may be related to intracranial excretory mechanisms and immune responses during youth, requiring further research.
Liszt’s Étude S.136 no.1: audio data analysis of two different piano recordings
Authors: Farnè Matteo 
Published: April 2024

AbstractIn this paper, we review the main signal processing tools of Music Information Retrieval (MIR) from audio data, and we apply them to two recordings (by Leslie Howard and Thomas Rajna) of Franz Liszt’s Étude S.136 no.1, with the aim of uncovering the macro-formal structure and comparing the interpretative styles of the two performers. In particular, after a thorough spectrogram analysis, we perform a segmentation based on the degree of novelty, in the sense of spectral dissimilarity, calculated frame-by-frame via the cosine distance. We then compare the metrical, temporal and timbrical features of the two executions by MIR tools. Via this method, we are able to identify in a data-driven way the different moments of the piece according to their melodic and harmonic content, and to find out that Rajna’s execution is faster and less various, in terms of intensity and timbre, than Howard’s one. This enquiry represents a case study able to show the potentialities of MIR from audio data in supporting traditional music score analyses and in providing objective information for statistically founded musical execution analyses.
Non-squamous Cancers of the Larynx
Authors: Cobanoglu H. Bengu , Koprucu Erdal Rahman 
Published: April 2024

Abstract
Purpose of Review
Although non-squamous tumors of the larynx are really rare, they may not always be viewed from the same perspective in the multidisciplinary treatment approach once the diagnosis is made. In this review, non-squamous tumors of the larynx and current approaches in treatment will be discussed.

Recent Findings
When the studies and meta-analyses presented in the last 5 years are evaluated, it is seen that these tumors usually show non-specific symptoms. Due to their submucosal location, the stage of the disease at the time of diagnosis is often advanced. In the literature, treatment may vary in these particular cases.

Summary
The majority of non-squamous tumors of the larynx includes minor salivary gland tumors, neuroendocrine carcinomas, sarcomas, cartilage tumors, and malignant melanomas. Once treating a patient with these diagnoses, it should be kept in mind that the histopathological subtype is almost as important as the stage of the tumor.
Behavioral and Metabolic Effects of ABCG4 KO in the APPswe,Ind (J9) Mouse Model of Alzheimer’s Disease
Authors: Fong Vincent , Kanuri Babunageswararao , Traubert Owen , Lui Min , Patel Shailendra B. 
Published: April 2024

AbstractThe pathogenesis of Alzheimer’s disease (AD) is complex and involves an imbalance between production and clearance of amyloid-ß peptides (Aß), resulting in accumulation of Aß in senile plaques. Hypercholesterolemia is a major risk factor for developing AD, with cholesterol shown to accumulate in senile plaques and increase production of Aß. ABCG4 is a member of the ATP-binding cassette transporters predominantly expressed in the CNS and has been suggested to play a role in cholesterol and Aß efflux from the brain. In this study, we bred Abcg4 knockout (KO) with the APPSwe,Ind (J9) mouse model of AD to test the hypothesis that loss of Abcg4 would exacerbate the AD phenotype. Unexpectedly, no differences were observed in novel object recognition (NOR) and novel object placement (NOP) behavioral tests, or on histologic examinations of brain tissues for senile plaque numbers. Furthermore, clearance of radiolabeled Aß from the brains did not differ between Abcg4 KO and control mice. Metabolic testing by indirect calorimetry, glucose tolerance test (GTT), and insulin tolerance test (ITT) were also mostly similar between groups with only a few mild metabolic differences noted. Overall, these data suggest that the loss of ABCG4 did not exacerbate the AD phenotype.
Propagation properties of a non-linear mapping based on squaring in odd characteristic
Authors: Daemen Joan , Kuijsters Daniël , Mella Silvia , Verbakel Denise 
Published: April 2024

AbstractMany modern cryptographic primitives for hashing and (authenticated) encryption make use of constructions that are instantiated with an iterated cryptographic permutation that operates on a fixed-width state consisting of an array of bits. Often, such permutations are the repeated application of a relatively simple round function consisting of a linear layer and a non-linear layer. These constructions do not require that the underlying function is a permutation and they can plausibly be based on a non-invertible transformation. Recently, Grassi proposed the use of non-invertible mappings operating on arrays of digits that are elements of a finite field of odd characteristic for so-called MPC-/FHE-/ZK-friendly symmetric cryptographic primitives. In this work, we consider a mapping that we call $$\gamma $$
γ
that has a simple expression and is based on squaring. We discuss, for the first time, the differential and linear propagation properties of $$\gamma $$
γ
and observe that these follow the same rules up to a relabeling of the digits. This is an intriguing property that, as far as we know, only exists for $$\gamma $$
γ
and the binary mapping $$\chi _{3}$$

χ
3

that is used in the cryptographic permutation Xoodoo. Moreover, we study the implications of its non-invertibility on differentials with zero output difference and on biases at the output of the $$\gamma $$
γ
mapping and show that they are as small as they can possibly be.
Mental health promotion and suicide prevention in emerging adulthood: importance of psychoeducational interventions in University students
Authors: Pérez-Marín Marián , Lacomba-Trejo Laura , Giménez-Benavent Saray , Rodríguez-Fernández Aiara Auristela , Garcia-Iturrospe Eduardo Jesús Aguilar , Albiñana-Cruz Nuria , Andreu Yolanda , Badenes-Ribera Laura , Beleña-Mateo Ángela , Benavides-Gil Gemma , Carrillo-Díaz María , Castro-Calvo Jesús , Checa-Esquiva Irene , Cotolí-Crespo Amparo , Dasí Francisco , de la Barrera Usue , Esteras-Peña Jesús , Fuentes-Durá Inmaculada , García-Soriano Gemma , Gil-Juliá Beatriz , Iranzo-Tatay Carmen , Lucas-Molina Beatriz , Martínez-Besteiro Elvira , Montoya-Castilla Inmaculada , Muñoz-Navarro Roger , Nardi-Rodríguez Ainara , Ordóñez-López Ana , Palomares-Montero Davinia , Pamies-Aubalat Lidia , Pons-Cañaveras Diana , Roncero María , Roselló-Millet Patricia María , Schoeps Konstanze , Serrano-Pastor Lucas , Tamarit Alicia , Tomás-Miguel José Manuel , Valero-Moreno Selene , Velert-Jiménez Saray , Viguer-Seguí María Paz , Zacarés-González Juan José 
Published: April 2024

AbstractEmerging adulthood is a stage that involves significant changes in emotional, social, academic, and work domains, which can often lead to high levels of stress and mental health challenges. The purpose of this study is to explore the potential benefits of an online intervention program that is based on mental health psychoeducation and suicide risk prevention for emerging adults who are studying at university. A psychoeducational intervention was conducted with 567 participants, of whom 82.2% were female, aged between 18 and 29 years (M = 20.31; SD = 2.089). The study examines the intervention’s direct impact on adaptive knowledge of suicide risk and mental health, as well as its indirect effect on mental health indicators. The results showed that after the intervention, participants exhibited reduced stigma associated with mental health and suicide, improved knowledge, and more adaptive attitudes towards suicide. Significant changes were observed in various psychological variables, including self-esteem, resilience, emotional regulation, anxiety, depression, stress, and suicide risk, in the expected direction. These findings suggest that integrating psychoeducational interventions and suicide prevention programs into university curricula could promote mental well-being and address suicide risk among emerging adult students.
The relationship between adverse childhood experiences and social anxiety disorder symptoms: the mediating role of rumination
Authors: Kurtoğlu M. Batuhan , Yücel Duygu , Coşkun Esra , Katar Kübra Sezer 
Published: April 2024

AbstractThis study aimed to examine the mediating role of rumination in the relationship between adverse childhood experiences and social anxiety disorder symptoms. In this study, which was conducted with correlational design, one of the quantitative research methods, 878 participants were reached. 78.2% of the participants are women and 21.8% are men. In the study, self-report scales consisting of a personal information form, adverse childhood experiences scale, rumination scale, and Liebowitz social anxiety scale were administered to the participants. The analysis of the data regarding the research findings was carried out using the SPSS 25 package program. First of all, the relationship between adverse childhood experiences and social anxiety and rumination was examined; Then, parallel multi-agent analysis and serial intermediary analyses were performed using the Process V4.2 extension (Model 4). According to the findings, it was found that there was a significant positive relationship between adverse childhood experiences, social anxiety disorder symptoms, and rumination variables. It has also been observed that rumination has a mediating role in the relationship between adverse childhood experiences and social anxiety disorder symptoms. Examining the role of rumination in the relationship between childhood adverse events and social anxiety symptoms may help develop new interventions targeting SAD and expand the literature on the cognitive, behavioral, and affective vulnerabilities that early adverse events bring with them.
A method for estimating the outer exposure of dairy cows to deoxynivalenol (DON) and zearalenone (ZEN) as a precondition for risk assessment based on inner exposure with toxin residue levels in blood and urine as indicators
Authors: Dänicke Sven , Saltzmann Janine , Waurich Benno , Wöckel Adriana , Wippermann Wolf , Hermenau Guntram , Wittich Julia , Bannert Erik , Rachidi Fanny , Hufe Peter , May Detlef , Swalve Hermann , Starke Alexander , Schären-Bannert Melanie 
Published: April 2024

AbstractDON and ZEN residues in the blood and urine of dairy cows can be used to predict the outer exposure to DON and ZEN expressed per kilogram diet for a risk evaluation based on comparisons to critical dietary concentrations. This method was used to evaluate the exposure of dairy cows from 12 farms located in Brandenburg, Germany, fed rations with unknown DON and ZEN concentrations (N = 244). The corresponding diet concentrations predicted by different methods from analyzed blood and urine samples varied significantly amongst farms from 0 to 1.6 mg/kg for DON and 0 to 3.0 mg/kg for ZEN at a reference dry matter content of 88% but independently of lactational state (post-partum vs. early lactation). This significant variation was noticed below the critical dietary DON concentration of 5 mg/kg, while the ZEN concentration in one farm exceeded the critical ZEN level of 0.5 mg/kg markedly. Predicted DON concentrations of rations increased with the proportion of maize silage, while the high ZEN concentration found in one farm was most likely related to a higher proportion of sugar beet pulp supposedly highly contaminated by ZEN. Exceeding the critical dietary ZEN concentration and significant variations in DON contents below the critical level was not related to performance, reproductive performance, and health-related traits of cows. For a more consistent evaluation of possible associations between the inner exposure of cows to DON and ZEN, more frequent longitudinal observations of both mycotoxin residue levels and performance and health traits are required.