bluuebunny/crossref_metadata_2025_split huggingface dataset:
Demographic differences in estimated blood donor eligibility prevalence in the United States
Authors: James Adelbert B. , Hillyer Christopher D. , Shaz Beth H. 
Published: November 2011

BACKGROUND: The prevalence of blood donor eligibility factors has a major impact on the availability of blood donors and thus the blood supply in the United States. The prevalence of these factors may differ between demographic groups and thus help explain the differences in blood donation rates.STUDY DESIGN AND METHODS: The study population (18‐69 years old who were African American [AA], white, or Hispanic) was 185,073,489. Forty eligibility factors determined by US Food and Drug Administration's Code of Federal Regulations and AABB Standards for Blood Banks and Transfusion Services were used to calculate whole blood donation eligibility rates. Eligibility data were obtained from the 2007 to 2008 National Health and Nutrition Examination Survey, National Ambulatory Medical Care Survey, US Census Bureau, and Centers for Disease Control and Prevention. Eligibility rates were determined by race/ethnicity, sex, and age groups (18‐39 and 40‐69 years).RESULTS: In 2007 to 2008, 122 million Americans (65.9% of the study population and 41.0% of the total US population) were estimated to be eligible to donate blood in the United States. Significant differences in eligibility rates by demographic characterizers were determined (p < 0.001): AAs (36.5%), whites (46.4%), and Hispanics (40.7%); males (45.4%) and females (42.7%); individuals 18 to 39 years old (35.8%); and individuals 40 to 69 years old (32.9%).CONCLUSIONS: AAs were significantly less eligible to donate blood than whites and Hispanics. Disparities in donor eligibility exist by race/ethnicity, sex, and age groups.
Epigenetic control of CCR5 transcript levels in immune cells and modulation by small molecules inhibitors
Authors: Wierda Rutger J. , Kuipers Hedwich F. , van Eggermond Marja C. J. A. , Benard Anne , van Leeuwen Jan C. , Carluccio Silvia , Geutskens Sacha B. , Jukema J. Wouter , Marquez Victor E. , Quax Paul H. A. , van den Elsen Peter J. 
Published: November 2011

AbstractPreviously, we have shown that CCR5 transcription is regulated by CREB‐1. However, the ubiquitous pattern of CREB‐1 expression suggests the involvement of an additional level of transcriptional control in the cell type–specific expression of CCR5. In this study, we show that epigenetic changes (i.e. DNA methylation and histone modifications) within the context of the CCR5 P1 promoter region correlate with transcript levels of CCR5 in healthy and in malignant CD4+ T lymphocytes as well as in CD14+ monocytes. In normal naïve T cells and CD14+ monocytes the CCR5 P1 promoter resembles a bivalent chromatin state, with both repressive and permissive histone methylation and acetylation marks. The CCR5‐expressing CD14+ monocytes however show much higher levels of acetylated histone H3 (AcH3) compared to the non–CCR5‐expressing naïve T cells. Combined with a highly methylated promoter in CD14+ monocytes, this indicates a dominant role for AcH3 in CCR5 transcription. We also show that pharmacological interference in the epigenetic repressive mechanisms that account for the lack of CCR5 transcription in T leukaemic cell lines results in an increase in CREB‐1 association with CCR5 P1 chromatin. Furthermore, RNA polymerase II was also recruited into CCR5 P1 chromatin resulting in CCR5 re‐expression. Together, these data indicate that epigenetic modifications of DNA, and of histones, contribute to the control of CCR5 transcription in immune effector cells.
CD68 and CD163 as prognostic factors for Korean patients with Hodgkin lymphoma
Authors: Yoon Dok Hyun , Koh Young Wha , Kang Hyo Jeong , Kim Shin , Park Chan‐Sik , Lee Sang‐wook , Suh Cheolwon , Huh Jooryung 
Published: November 2011

AbstractBackground:  Limited progress had been made in prognostic stratification of patients with Hodgkin lymphoma (HL) until recent studies suggested that the number of CD68‐expressing macrophages is prognostic in classical HL. However, its significance in Asian patients with HL has not been explored yet perhaps because of its low incidence in Asia.Methods:  In this work, we performed immunohistochemical analysis of CD163, as well as CD68, in 144 Korean patients with HL treated between November 1990 and December 2009 in a single center. The relative percentages of CD68+ and CD163+ cells with respect to the overall cellularity (CD68 index and CD163 index, respectively) were correlated with clinical outcomes.Results:  Both high CD68 and CD163 indices (>20%) were associated with a rise in treatment‐related deaths and poorer event‐free survival (P = 0.009 and P = 0.0023, respectively), disease‐specific survival (P = 0.011 and P = 0.001), and overall survival (P = 0.023 and P = 0.001). In particular, a high CD163 index was related to lower complete response (CR) rate (P = 0.022) and shorter duration of CR (P = 0.030).Conclusions:  High index of either CD68 or CD163 (>20%) is significantly correlated with poor prognosis in Korean patients with HL. CD163, a specific marker of macrophages, seems to be another prognostic factor for classical HL.
Geography: Space, Place and Intellectual History in the Eighteenth Century1
Authors: WITHERS CHARLES W. J. , MAYHEW ROBERT J. 
Published: November 2011

AbstractThe paper reviews work on geography as a subject and, more fully, studies that emphasise the value of ‘thinking geographically’– about the significance of place, space and scale – in understanding the nature of eighteenth‐century life and intellectual culture.
Immunohistological analysis of extracted anterior cruciate ligament graft impinged against posterior cruciate ligament
Authors: Kato So , Fukai Atsushi , Takeda Hideki , Taketomi Shuji , Nakayama Shuichi , Hirota Jinso , Nakajima Kohei , Nakamura Kozo , Nakagawa Takumi 
Published: November 2011

Abstract
A young female athlete suffered from the residual instability of the knee after anterior cruciate ligament (ACL) reconstruction with hamstring autograft. The 3-dimensional (3-D) CT scan showed the "high noon" positioning of the primary femoral bone tunnel. The revision surgery with anatomic double-bundle technique was performed two years after the primary surgery and the femoral tunnels were created with the assistance of the 3-D fluoroscopy-based navigation. An arthroscopic examination confirmed the ACL graft impingement against posterior cruciate ligament (PCL) when the knee was deeply flexed. The histological analysis of the resected primary ACL graft showed local inflammatory infiltration, enhanced synovial coverage and vascularization at the impinged site. The enhanced expression of vascular endothelial growth factor (VEGF) at the impinged area when compared with non-impinged area was observed on immunohistochemical analysis. Abnormal mechanical stress by the impingement against PCL might have induced chronic inflammation and VEGF overexpression.
Azolylborates for Electrochemical Double Layer Capacitor Electrolytes
Authors: Francke Robert , Cericola D. , Kötz R. , Waldvogel Siegfried R. 
Published: November 2011

Abstract
Asymmetric tetraalkylammonium salts of azolylborates were synthesized and studied with respect to their suitability as supporting electrolytes in electrochemical double layer capacitors. In contrast to current conducting salts used in this device, azolylborates exhibit an excellent stability towards thermal load and moisture. In addition to good conductivity and stability towards cathodic reduction we found certain limitations when more positive potentials were applied.
Epidemiology of Anxiety Disorders in the Australian General Population: Findings of the 2007 Australian National Survey of Mental Health and Wellbeing
Authors: McEvoy Peter M. , Grove Rachel , Slade Tim 
Published: November 2011

Objective: The aims of this study were to report 12-month and lifetime prevalence for anxiety disorders in the Australian general population, identify sociodemographic and clinical correlates of anxiety disorders, and report the rates of comorbidity among anxiety, affective, and substance use disorders across the lifespan. Method: The 2007 National Survey of Mental Health and Wellbeing was a nationally representative, face-to-face household survey of 8841 (60% response rate) community residents aged between 16 and 85 years. Diagnoses for anxiety, affective and substance use disorders were made according to the DSM-IV using the World Mental Health Survey Initiative version of the Composite International Diagnostic Interview. Results: 12-month and lifetime prevalence of anxiety disorders were 11.8% and 20.0%, respectively. Anxiety disorders had a similar median age of onset (19 years) compared to substance use disorders (20 years), but earlier than affective disorders (34 years). Social phobia was the earliest onset anxiety disorder (median 13 years), with generalized anxiety disorder the latest (median 33 years). Significant correlates of the presence of anxiety disorders included being female, single, not in the labour force, in the middle age groups, not having post-graduate qualifications, having a comorbid physical condition, and having a family history of mental disorders. Being in the oldest age ranges and being born in another non-English speaking country were associated with lower odds of having an anxiety disorder. Body mass index was not associated with the presence of an anxiety disorder. Anxiety disorders were highly comorbid, particularly with major depression, dysthymia, and alcohol dependence. Comorbidity with substance use disorders reduced with age. Comorbidity with affective disorders was high across the lifespan. Conclusions: Anxiety disorders are common, can have an early onset, and are highly comorbid. Prevention, early detection, and treatment of anxiety disorders should be a priority.
The association between health information exchange and measures of patient satisfaction
Authors: Miller T.R. , Vest J.R. 
Published: November 2011

SummaryObjective: Health information exchange (HIE) is the interorganizational sharing of patient information and is one of many health information technology initiatives expected to transform the U.S. healthcare system. Two outcomes expected to be improved by HIE are patient-provider communication and patient satisfaction . This analysis examined the relationship between the level of HIE engagement and these two factors in a sample of U.S. hospitals.Methods: Independent variables came from existing secondary sources and the dependent measures were from the Hospital Consumer Assessment of Healthcare Providers and Systems. The analysis included 3,278 hospitals. Using ordinary least squares regression, implemented HIE was positively associated with the percentage of patients reporting nurses communicated well and higher satisfaction. Due to the potential for selection bias, results were further explored using a propensity score analysis.Results: Hospitals that had adopted HIE, but not yet implemented saw no benefits. Hospitals’ level of HIE was not associated with the percentage of patients reporting doctors communicated well. According to propensity score corrected estimates, implemented HIE was associated with the percentage of patients who reported nurses always communicated well and who would definitely recommend the hospital.Conclusion: Few studies have examined the impact of HIE at the organizational level. This examination provides some evidence that hospitals engaging in HIE are associated with higher patient satisfaction.
Effectiveness of a clinical practice intervention in early rheumatoid arthritis
Authors: Descalzo Miguel Ángel , Carbonell Jordi , González‐Álvaro Isidoro , Sanmartí Raimon , Balsa Alejandro , Hernandez‐Barrera Valentín , Román‐Ivorra José Andrés , Ivorra‐Cortés José , Lisbona Pilar , Alperi Mercedes , Jiménez‐Garcia Rodrigo , Carmona Loreto ,   SERAP and PROAR Study Groups
Published: November 2011

AbstractObjectiveTo compare the outcome of early rheumatoid arthritis (RA) patients in a country where early clinics were established versus the outcome of patients in nonprotocolized clinics.MethodsWe compared 2 multicenter cohorts: an RA cohort derived from an early arthritis registry set in 36 reference hospitals in which a specific intervention was established (Evaluation of a Model for Arthritis Care in Spain [SERAP]), and a historical control cohort of patients with early RA attending 34 rheumatology departments (Prognosis in Rheumatoid Arthritis [PROAR] cohort). Effectiveness was tested by comparing the change in the Disease Activity Score in 28 joints (DAS28), the change in the Health Assessment Questionnaire (HAQ), and the change in the Sharp/van der Heijde radiologic score using marginal structural models.ResultsA total of 161 early RA patients were recruited in the PROAR cohort and 447 in the SERAP cohort. Being a SERAP patient was inversely correlated with activity, resulting in a decrease of −0.24 (95% confidence interval [95% CI] −0.39, −0.08) units in the population average of the DAS28 after adjustment was made. Moreover, intervention may be seen as a protective factor of radiologic damage, with a decrease of −0.05 (95% CI −0.09, −0.01) units in the logarithm of the total Sharp/van der Heijde score. On the other hand, a decrease in functional impairment was detected, but intervention was not statistically associated with HAQ changes.ConclusionPreventing major radiographic progression in a 2‐year term inside structured and organized special programs for the management of disease, such as early arthritis clinics, are effective compared to nonprotocolized referrals, treatment, and followup.
Determinants of discordance in patients' and physicians' rating of rheumatoid arthritis disease activity
Authors: Khan Nasim A. , Spencer Horace J. , Abda Esam , Aggarwal Amita , Alten Rieke , Ancuta Codrina , Andersone Daina , Bergman Martin , Craig‐Muller Jurgen , Detert Jacqueline , Georgescu Lia , Gossec Laure , Hamoud Hisham , Jacobs Johannes W. G. , Laurindo Ieda Maria Magalhaes , Majdan Maria , Naranjo Antonio , Pandya Sapan , Pohl Christof , Schett Georg , Selim Zahraa I. , Toloza Sergio , Yamanaka Hisahi , Sokka Tuulikki 
Published: November 2011

AbstractObjectiveTo assess the determinants of patients' (PTGL) and physicians' (MDGL) global assessment of rheumatoid arthritis (RA) activity and factors associated with discordance among them.MethodsA total of 7,028 patients in the Quantitative Standard Monitoring of Patients with RA study had PTGL and MDGL assessed at the same clinic visit on a 0–10‐cm visual analog scale (VAS). Three patient groups were defined: concordant rating group (PTGL and MDGL within ±2 cm), higher patient rating group (PTGL exceeding MDGL by >2 cm), and lower patient rating group (PTGL less than MDGL by >2 cm). Multivariable regression analysis was used to identify determinants of PTGL and MDGL and their discordance.ResultsThe mean ± SD VAS scores for PTGL and MDGL were 4.01 ± 2.70 and 2.91 ± 2.37, respectively. Pain was overwhelmingly the single most important determinant of PTGL, followed by fatigue. In contrast, MDGL was most influenced by swollen joint count (SJC), followed by erythrocyte sedimentation rate (ESR) and tender joint count (TJC). A total of 4,454 (63.4%), 2,106 (30%), and 468 (6.6%) patients were in the concordant, higher, and lower patient rating groups, respectively. Odds of higher patient rating increased with higher pain, fatigue, psychological distress, age, and morning stiffness, and decreased with higher SJC, TJC, and ESR. Lower patient rating odds increased with higher SJC, TJC, and ESR, and decreased with lower fatigue levels.ConclusionNearly 36% of patients had discordance in RA activity assessment from their physicians. Sensitivity to the “disease experience” of patients, particularly pain and fatigue, is warranted for effective care of RA.
Characterization of the curing process of vinyl plastisols with epoxidized linseed oil as a natural‐based plasticizer
Authors: Fenollar O. , Garcia‐Sanoguera D. , Sánchez‐Nácher L. , López J. , Balart R. 
Published: November 2011

AbstractIn this work, we have evaluated the curing process of a natural‐based plasticizer, epoxidized linseed oil, as a possible alternative to phthalate substitution for polyvinyl chloride. Several curing times ranging from 6 to 14 min at different isothermal curing temperatures in the 140–220°C range have been selected. The effects of the curing process (in terms of time and temperature) have been determined by mechanical tests, color measurements, and microstructure characterization. The obtained results show that optimum overall properties are obtained for curing times of 10–12 min at 200°C or 8 min at 220°C, which are typical values of industrial processing of vinyl plastisols. © 2011 Wiley Periodicals, Inc. J Appl Polym Sci, 2012
Synthesis and properties of trifluoromethyl groups containing epoxy resins cured with amine for low Dk materials
Authors: Wang J. Y. , Yang S.Y. , Huang Y.L. , Tien H.W. , Chin W.K. , Ma C.C.M. , Shu W.J. 
Published: November 2011

AbstractThe study synthesized a trifluoromethyl (CF3) groups with a modified epoxy resin, diglycidyl ether of bisphenol F (DGEBF), using environmental friendly methods. The epoxy resin was cured with 4,4′‐diaminodiphenyl‐methane (DDM). For comparison, this study also investigated curing of commercially available diglycidyl ether of bisphenol A (DGEBA) with the same curing agent by varying the ratios of DGEBF. The structure and physical properties of the epoxy resins were characterized to investigate the effect of injecting fluorinated groups into epoxy resin structures. Regarding the thermal behaviors of the specimens, the glass transition temperatures (Tg) of 50–160°C and the thermal decomposition temperatures of 200–350 °C at 5% weight loss (Td5%) in nitrogen decreased as amount of DGEBF increased. The different ratios of cured epoxy resins showed reduced dielectric constants (Dk) (2.03–3.80 at 1 MHz) that were lower than those of pure DGEBA epoxy resins. Reduced dielectric constant is related to high electrronegativity and large free volume of fluorine atoms. In the presence of hydrophobic CF3 groups, the epoxy resins exhibited low moisture absorption and higher contact angles. © 2011 Wiley Periodicals, Inc. J Appl Polym Sci, 2012
Cdc20 control of cell fate during prolonged mitotic arrest
Authors: Nilsson Jakob 
Published: November 2011

AbstractThe fate of cells arrested in mitosis by antimitotic compounds is complex but is influenced by competition between pathways promoting cell death and pathways promoting mitotic exit. As components of both of these pathways are regulated by Cdc20‐dependent degradation, I hypothesize that variations in Cdc20 protein levels, rather than mutations in checkpoint genes, could affect cell fate during prolonged mitotic arrest. This hypothesis is supported by experiments where manipulation of Cdc20 levels affects the response to antimitotic compounds. The observed differences in Cdc20 levels between cell lines likely reflects differences in the rate of synthesis or degradation of the protein; therefore, understanding these pathways at a molecular level could pave the way for modulating the activity of Cdc20, in turn presenting novel therapeutic possibilities.
Ferrocene‐Conjugated Oxidovanadium(IV) Complexes as Potent Near‐IR Light Photocytotoxic Agents
Authors: Balaji Babu , Banik Bhabatosh , Sasmal Pijus K. , Maity Basudev , Majumdar Ritankar , Dighe Rajan R. , Chakravarty Akhil R. 
Published: November 2011

AbstractFerrocene‐conjugated oxidovanadium(IV) complexes [VO(Fc‐tpy)(B)](ClO4)2 (1–4) and [VO(Ph‐tpy)(dppz)](ClO4)2 (5) as a control [Fc = (η5‐C5H4)FeII(η5‐C5H5), Fc‐tpy = 4′‐ferrocenyl‐2,2′:6′,2″‐terpyridine, Ph‐tpy = 4′‐phenyl‐2,2′:6′,2″‐terpyridine, B = heterocyclic base: 2,2′‐bipyridine (bpy in 1), 1,10‐phenanthroline (phen in 2), dipyridoquinoxaline (dpq in 3), dipyridophenazine (dppz in 4)] were prepared and their DNA binding, DNA photocleavage activity and photocytotoxicity studied. The crystal structure of [VO(Fc‐tpy)(bpy)](PF6)2·3Me2CO shows a vanadyl group in six‐coordinate VIVON5 coordination geometry, in which Fc‐tpy and bpy display tridentate meridional and bidentate N‐donor axial–equatorial binding modes, respectively. The one‐electron paramagnetic complexes exhibit a charge‐transfer band near 590 nm in DMF. The VIV/VIII redox couple in 1–4 appears near –0.7 V, whereas the Fc moiety shows a response near 0.6 V vs. SCE in DMF/0.1 M TBAP. The complexes are good binders to calf thymus DNA with Kb values of 104–106 M–1. DNA melting and viscometric data suggest groove and/or partial intercalative DNA binding of the complexes. Complexes 3–5 display DNA photocleavage activity in near‐IR light of 785 nm. Complex 4 shows significant photocytotoxicity in visible light (400–700 nm) in HeLa cells with low dark toxicity.
Bankruptcy‐based radio resource management for multimedia mobile networks
Authors: Lucas‐Estañ M. C. , Gozalvez J. , Sanchez‐Soriano J. 
Published: November 2011

ABSTRACTThe transmission of bandwidth‐demanding multimedia applications in capacity‐constrained mobile radio networks requires optimizing the usage and assignment of radio resources following the varying quality of service requirement characteristics of multimedia traffic environments. Considering the capacity of the bankruptcy theory to deal with situations where the demand for resources is higher than its availability, this work proposes the application of bankruptcy theories to design efficient radio resource management policies that provide the highest possible quality of service levels while guaranteeing user fairness. Copyright © 2011 John Wiley & Sons, Ltd.
Significant association of SRC protein expression with the progression, recurrence, and prognosis of oral squamous cell carcinoma in Taiwan
Authors: Cheng Shih–Jung , Kok Sang–Heng , Lee Jang–Jaer , Yen–Ping Kuo Mark , Cheng Shih–Lung , Huang Ying–Luo , Chen Hsin–Ming , Chang Hao–Hueng , Chiang Chun–Pin 
Published: November 2011

AbstractBackgroundSrc protein overexpression correlates with progression and prognosis of a variety of human cancers.MethodsThis study used immunohistochemistry to examine the expression of Src protein in 93 specimens of oral squamous cell carcinoma (OSCC).ResultsWe found a significant association of high expression of Src protein (labeling indices >50%) with larger tumor size (p = .017), positive lymph node metastasis (p = .030), more advanced clinical stages (p = .007), and recurrence (p < .001) of OSCC. High expression of Src protein was identified as an independent unfavorable prognosis factor by multivariate Cox regression analysis. The Kaplan–Meier curve showed that patients with OSCC with high expression of Src protein had a significantly poorer cumulative survival than those with low expression of Src protein (log‐rank test, p = .00267).ConclusionThe expression of Src protein is significantly associated with the progression, recurrence, and prognosis of OSCCs in Taiwan. © 2011 Wiley Periodicals, Inc. Head Neck, 2012