bluuebunny/crossref_metadata_2025_split huggingface dataset:
Anti–prostate‐Specific membrane antigen‐based radioimmunotherapy for prostate cancer
Authors: Tagawa Scott T. , Beltran Himisha , Vallabhajosula Shankar , Goldsmith Stanley J. , Osborne Joseph , Matulich Dan , Petrillo Kristen , Parmar Sarojben , Nanus David M. , Bander Neil H. 
Published: February 2010

AbstractDespite recent advances, advanced prostate cancer is suboptimally responsive to current chemotherapeutic agents. Radiolabeled monoclonal antibody therapy that targets prostate‐specific membrane antigen (PSMA) shows promise and is an area of active investigation. J591 is a deimmunized IgG monoclonal antibody developed to target the extracellular domain of PSMA. Preclinical and early phase clinical studies using radiolabeled J591 have demonstrated efficacy in targeting tumor cells and decreasing levels of prostate‐specific antigen. Radiolabeled J591 is well‐tolerated, nonimmunogenic, and can be administered in multiple doses. The dose‐limiting toxicity is reversible myelosuppression with little nonhematologic toxicity. Future studies will include approaches to optimize patient selection and incorporate novel strategies to improve the success of anti‐PSMA radioimmunotherapy. Cancer 2010;116(4 suppl):1075–83. © 2010 American Cancer Society.
Pretargeted radioimmunoscintigraphy in patients with primary colorectal cancer using a bispecific anticarcinoembryonic antigen CEA X anti‐di‐diethylenetriaminepentaacetic acid F(ab′)2 antibody
Authors: Aarts Frits , Boerman Otto C. , Sharkey Robert M. , Hendriks Thijs , Chang Chien‐Hsing , McBride William J. , Bleichrodt Robert P. , Oyen Wim J. G. , Goldenberg David M. 
Published: February 2010

AbstractBACKGROUND:Antibody‐based imaging agents are available commercially, but their success has been limited, mainly because of low contrast and the emergence of 2‐fluoro‐2‐deoxy‐D‐glucose‐positron emission tomography (FDG‐PET) scanning. In pretargeting, administration of the radionuclide is separated from the antibody, thereby enhancing image contrast and allowing detection at earlier time points after injection.METHODS:The authors conducted an open‐label, single‐arm trial that assessed a pretargeting procedure in which an anticarcinoembryonic antigen x (anti‐CEA x) anti‐diethylenetriaminepentaacetic acid (anti‐DTPA)‐indum (In) antibody was used in combination with a 111In‐labeled di‐DTPA peptide for the diagnostic imaging of CEA‐expressing colorectal cancer. Three patients received the 111In peptide alone to investigate tumor targeting, organ distribution, and clearance of the peptide. Thereafter, 11 patients received the bispecific antibody (bsAb) (5 mg) to pretarget the tumor. After 3 to 5 days, patients were injected with 185 megabecquerels of 111In‐labeled peptide to assess the optimal interval for best image quality.RESULTS:Fourteen patients with primary colorectal cancer were enrolled. One of 3 patients who received 111In peptide alone had low‐level tumor uptake. In 9 of 11 other patients, tumors were observed. In 1 patient, FDG‐PET–positive lymph nodes were observed clearly with pretargeted immunoscintigraphy. Peptide pharmacokinetics revealed enhanced circulating levels of 111In‐labeled peptide in patients in the 3‐day interval cohort compared with the other cohorts. Tumor‐to‐background ratios ranged from 3.5 to 6.4 in the 3‐day interval group, from 5.1 to 14.2 in the 4‐day interval group, and from 3.5 to 3.9 in the 5‐day interval group. The best images were acquired with a 4‐day interval at 24 hours after injection of the radiolabeled peptide. Grade 1 adverse events were observed in 2 patients.CONCLUSIONS:Imaging of colorectal cancer using a 2‐step, pretargeting system produced the best imaging results 24 hours after peptide administration using a 4‐day interval between injection of the bsAb and the peptide. Cancer 2010;116(4 suppl):1111–7. © 2010 American Cancer Society.
Pretargeted radioimmunotherapy in rapidly progressing, metastatic, medullary thyroid cancer
Authors: Kraeber‐Bodéré Françoise , Salaun Pierre‐Yves , Oudoux Aurore , Goldenberg David M. , Chatal Jean‐François , Barbet Jacques 
Published: February 2010

AbstractMedullary thyroid cancer (MTC) patients with localized residual disease and/or distant metastases may survive for several years or rapidly progress and die of their disease. Thus, highly reliable prognostic factors are needed for an early distinction between high‐risk patients who need to be treated and low‐risk patients who warrant a watch‐and‐wait approach. Calcitonin doubling time is an independent predictor of survival, with a high predictive value in a population of patients who have not normalized their calcitonin, even after repeated surgery. Several imaging methods should be proposed for patients with abnormal residual calcitonin levels persisting after complete surgery: ultrasonography and computed tomography (CT) for neck exploration, and CT for chest, abdomen, and pelvis. Magnetic resonance imaging (MRI) appears to have an advantage over CT for the detection of liver metastases from endocrine tumors. Moreover, MRI appears to be a sensitive imaging technique for detecting the spread of MTC to bone/bone marrow. 2‐Fluoro‐2‐deoxy‐D‐glucose positron emission tomography/CT could be used for staging patients with progressive MTC, with possible prognostication by standard uptake value quantification. For systemic treatment of patients with rapidly progressing metastatic MTC, chemotherapy is not considered a valid therapeutic option. It is too early to evaluate the potential effectiveness of multikinase inhibitors, although interesting results of phase 2 studies have shown a transient stabilization in 30% to 50% of patients. Pretargeted radioimmunotherapy has been the only innovative treatment modality convincingly showing some survival benefit when compared with a historical untreated control group. Cancer 2010;116(4 suppl):1118–25. © 2010 American Cancer Society.
Processing of pictorial food stimuli in patients with eating disorders—A systematic review
Authors: Giel Katrin Elisabeth , Teufel Martin , Friederich Hans‐Christoph , Hautzinger Martin , Enck Paul , Zipfel Stephan 
Published: February 2010

AbstractObjective:The processing of food cues in eating‐disordered patients has recently been increasingly investigated. Outlined is current evidence from pictorial food stimuli studies.Method:PubMed and PsychINFO were searched for quantitative pictorial food stimuli studies investigating healthy controls and expert‐diagnosed eating‐disordered patients.Results:Patients with eating disorders (ED) demonstrated cue reactivity to food stimuli. Results from functional imaging suggest sensory disengagement and higher emotional involvement while self‐reported data and facial EMG revealed that food pictures were perceived as less pleasurable. Different experimental paradigms have demonstrated an attentional bias for food cues in ED. Currently, psychophysiological data is widely inconclusive.Discussion:Evidence suggests cue reactivity to food pictures in eating‐disordered patients. However, the overall picture is inconclusive because methodological problems and the integration of findings from different experimental approaches pose a challenge to the research field. © 2010 by Wiley Periodicals, Inc.
Percent body fat is a risk factor for relapse in anorexia nervosa: A replication study
Authors: Bodell Lindsay P. , Mayer Laurel E.S. 
Published: February 2010

AbstractObjective:We aimed to replicate and extend our previous findings of an association between percent body fat in recently weight‐restored patients with Anorexia Nervosa (AN) and clinical outcome in the year following treatment.Method:Twenty‐two hospitalized, weight‐restored women with AN underwent whole body MRI to determine percent adipose tissue. Following hospital discharge, patients were contacted regularly, and at the end of the year, clinical outcome was determined using modified Morgan‐Russell (MR) criteria: full, good, fair or poor. Identical to our previous study, outcome was dichotomized into “full, good or fair” and “poor” groups.Results:Data from 21 subjects were available for analysis. Percent body fat was significantly lower in the poor outcome group (22% ±5%) compared to the “full, good or fair” outcome group (27 % ±4%)(p < 0.035). To further examine the relationship, we combined data from the current study with data from the 26 subjects on whom we had previously reported. Univariate analysis of variance (ANOVA) demonstrated a significant difference in percent adipose tissue across the four MR outcome groups (F = 3.416, df = 3, p<0.03).Discussion:Lower percent adipose tissue after short‐term weight normalization is associated with poor clinical outcome in the year following inpatient treatment. These findings may be important in the assessment of risk for relapse in patients with AN. © 2010 by Wiley Periodicals, Inc.
A General Solvothermal Route to the Synthesis of CoTe, Ag2Te/Ag, and CdTe Nanostructures with Varied Morphologies
Authors: Jiang Ling , Zhu Ying‐Jie 
Published: February 2010

AbstractA general and facile surfactant‐assisted solvothermal route was developed for the synthesis of CoTe, Ag2Te/Ag, and CdTe nanostructures using the corresponding metal salt,Na2TeO3, ascorbic acid, and polyvinyl pyrrolidone (PVP) or cetyltrimethylammonium bromide (CTAB) in mixed solvents of ethanolamine and water. It was also found that the morphology of the product varied dramatically when using different surfactants such as PVP and CTAB. A formation mechanism of telluride nanostructures was proposed. The products were characterized by X‐ray powder diffraction (XRD), transmission electron microscopy (TEM), thermogravimetry (TG), and differential scanning calorimetric (DSC) analysis.
Formation of Oxaphosphacarbenes by Reaction of [RuTpCl(PPh3)(thp)] with Terminal Alkynes and a Propargylic Alcohol (Eur. J. Inorg. Chem. 5/2010)
Authors: Bolaño Sandra , Bravo Jorge , Castro Jesús , Rodríguez‐Rocha Mar 
Published: February 2010

AbstractThe cover picture shows the structure of a five‐membered cyclic ruthenium oxaphosphacarbene complex [TpRuCl{κ2‐(C,P)=C(CH2R)OCH2P(CH2OH)2}] (R = p‐C6H4Me). Different neutral and cationic oxaphosphacarbene complexes were obtained by reaction of [TpRuCl(PPh3)(thp)] with terminal alkynes. The proposed mechanism implies vinylidene or allenylidene intermediates that undergo intramolecular nucleophilic addition to the α‐carbon atom by one of the hydroxymethyl groups of the thp ligand. Details are discussed in the article by S. Bolan˜o, J. Bravo et al. on p. 685 ff. We thank Dr. Carlos Silva for help in designing this picture.
Asymmetric Cyanosilylation of α‐Keto Esters Catalyzed by the [Ru(phgly)2(binap)]–C6H5OLi System
Authors: Kurono Nobuhito , Uemura Masato , Ohkuma Takeshi 
Published: February 2010

AbstractThe asymmetric reaction of α‐keto esters and (CH3)3SiCN, catalyzed by a combined system of [Ru{(S)‐phgly}2{(S)‐binap}] and C6H5OLi with a substrate‐to‐catalyst molar ratio (S/C) of 1000 at –60 °C, affords silylated cyanohydrins in up to 99 % ee. Cyanosilylation smoothly proceeds with an S/C of 10,000 at –50 °C. The use of Xyl‐Binap instead of Binap as a ligand provides better enantioselectivity in some cases. A series of aromatic, hetero‐aromatic, aliphatic, and α,β‐unsaturated keto esters are converted into the desired products.
Urbanization impacts upon catchment hydrology and gully development using mutli‐temporal digital elevation data analysis
Authors: Junior Osmar Carvalho , Guimaraes Renato , Freitas Leonardo , Gomes‐Loebmann Daniel , Gomes Roberto Arnaldo , Martins Eder , Montgomery David R. 
Published: February 2010

AbstractUrbanization can change catchment hydrology, accelerating gully erosion and causing serious damage to urban structures like roads, bridges and buildings. Increased impervious surfaces lead to large, rapid increases in surface runoff in urban catchments during storm events, as well as changes in the upslope contributing area due to rerouting of urban runoff that can exacerbate erosion. Accounting for changes in surface drainage patterns Gama City, Brazil, is used to predict areas prone to accelerate gullying and develop a method of assessing the potential for gully erosion produced by urbanization. The method is based on the analysis and comparison of detailed digital elevation models (DEMs) of the natural condition before urbanization and the topography after urbanization. The study site is located in an area where changes in drainage patterns associated with rapid urbanization in the last 30 years have resulted in severe gullying. Our analysis identifies areas potentially susceptible to gullying and highlights the erosional influence of increased flow concentration caused by urban occupation, a finding that has implications and applications for strategies to prevent gully development in cities or areas undergoing urban expansion. Copyright © 2010 John Wiley & Sons, Ltd.
A modified static hedging method for continuous barrier options
Authors: Chung San‐Lin , Shih Pai‐Ta , Tsai Wei‐Che 
Published: February 2010

AbstractThis study modifies the static replication approach of Derman, E., Ergener, D., and Kani, I. (1995, DEK) to hedge continuous barrier options under the Black, F. and Scholes, M. (1973) model. In the DEK method, the value of the static replication portfolio, consisting of standard options with varying maturities, matches the zero value of the barrier option at n evenly spaced time points when the stock price equals the barrier. In contrast, our modified DEK method constructs a portfolio of standard options and binary options with varying maturities to match not only the zero value but also zero theta on the barrier. Our numerical results indicate that the modified DEK approach improves performance of static hedges significantly for an up‐and‐out call option under the BS model even if the bid–ask spreads are considered. © 2010 Wiley Periodicals, Inc. Jrl Fut Mark
Event‐related potential and functional MRI measures of face‐selectivity are highly correlated: A simultaneous ERP‐fMRI investigation
Authors: Sadeh Boaz , Podlipsky Ilana , Zhdanov Andrey , Yovel Galit 
Published: February 2010

AbstractA face‐selective neural signal is reliably found in humans with functional MRI and event‐related potential (ERP) measures, which provide complementary information about the spatial and temporal properties of the neural response. However, because most neuroimaging studies so far have studied ERP and fMRI face‐selective markers separately, the relationship between them is still unknown. Here we simultaneously recorded fMRI and ERP responses to faces and chairs to examine the correlations across subjects between the magnitudes of fMRI and ERP face‐selectivity measures. Findings show that the face‐selective responses in the temporal lobe (i.e., fusiform gyrus—FFA) and superior temporal sulcus (fSTS), but not the face‐selective response in the occipital cortex (OFA), were highly correlated with the face‐selective N170 component. In contrast, the OFA was correlated with earlier ERPs at about 110 ms after stimulus‐onset. Importantly, these correlations reveal a temporal dissociation between the face‐selective area in the occipital lobe and face‐selective areas in the temporal lobe. Despite the very different time‐scale of the fMRI and EEG signals, our data show that a correlation analysis across subjects may be informative with respect to the latency in which different brain regions process information. Hum Brain Mapp, 2010. © 2010 Wiley‐Liss, Inc.
‘Play skills’ for shy children: development of a Social Skills Facilitated Play early intervention program for extremely inhibited preschoolers
Authors: Coplan Robert J. , Schneider Barry H. , Matheson Adrienne , Graham Allison 
Published: February 2010

AbstractThe aim of the present study was to develop and provide a preliminary evaluation of a social‐skills‐based early intervention program specifically designed to assist extremely inhibited preschoolers. Participants were a sample of n=22 extremely inhibited preschool‐aged children, who were randomly assigned to either the Social Skills Facilitated Play (SST) or Waitlist Control (WLC) condition. As compared to wait‐list controls, extremely inhibited children who participated in the SST‐facilitated play program sessions demonstrated a significantly greater post‐intervention decrease in observed socially wary behaviours and a significantly greater increase in social and socially competent behaviours at preschool. Results are discussed in terms of the importance of developing and refining early intervention programs for extremely inhibited young children. Copyright © 2010 John Wiley & Sons, Ltd.
Curcumin upregulates insulin‐like growth factor binding protein‐5 (IGFBP‐5) and C/EBPα during oral cancer suppression
Authors: Chang Kuo‐Wei , Hung Pei‐Shih , Lin I‐Ying , Hou Chung‐Ping , Chen Li‐Kai , Tsai Yin‐Meng , Lin Shu‐Chun 
Published: February 2010

AbstractCurcumin is a common food ingredient derived from the plant Curcuma longa and is a potent drug against tumorigenesis. Both insulin‐like growth factor binding protein‐5 (IGFBP‐5) and CCAAT/enhancer‐binding protein α (C/EBPα) are suppressors of head and neck carcinogenesis. We identified curcumin as an inducer of IGFBP‐5 expression in multiple types of oral keratinocytes; furthermore, curcumin induces IGFBP‐5 promoter activity in SAS oral cancer cells. Promoter deletion mapping identified a region (nt −71 to nt −59 relative to the transcription start site) as containing a C/EBPα‐binding element that is indispensable for curcumin‐mediated IGFBP‐5 upregulation. Chromatin immunoprecipitation assays revealed that in vivo binding of C/EBPα to this region was remarkably increased in the presence of curcumin. Curcumin increased nuclear C/EBPα expression and IGFBP‐5 expression through p38 activation and this was abrogated by SB203580 treatment. Furthermore, MKK6 expression activated p38 and C/EBPα, increasing IGFBP‐5 promoter activity and expression. Finally, curcumin‐induced IGFBP‐5 expression is associated with the suppression of xenograft tumorigenesis in mice due to oral cancer cells. We conclude that curcumin activates p38, which, in turn, activates the C/EBPα transactivator by interacting with binding elements in the IGFBP‐5 promoter. The consequential upregulation of C/EBPα and IGFBP‐5 by curcumin is crucial to the suppression of oral carcinogenesis.
Intraepithelial p63‐dependent expression of distinct components of cell adhesion complexes in normal esophageal mucosa and squamous cell carcinoma
Authors: Thépot Amélie , Hautefeuille Agnès , Cros Marie‐Pierre , Abedi‐Ardekani Behnoush , Pétré Aurélia , Damour Odile , Krutovskikh Vladimir , Hainaut Pierre 
Published: February 2010

AbstractTP63 gene is a member of TP53 tumor suppressor gene family that encodes several protein isoforms involved in the process of epithelial stratification and in epithelial‐mesenchyme interactions. TP63 is amplified in a significant proportion of squamous cell carcinoma of the esophagus (ESCC), resulting in the hyper‐expression of ΔNp63 as the major p63 isoform. To better understand the contribution of this high expression to tumorigenesis, we have analyzed the impact of intraepithelial p63 expression on the expression of cell adhesion complexes in normal esophagus and in ESCC cell lines. Cells expressing p63 showed an adhesion pattern characterized by lack of tight junctions and presence of adherens junctions. Cell differentiation was accompanied by a decrease in p63 and by a shift to adhesion patterns involving tight junctions. Silencing of p63 mRNA in ESCC cell lines resulted in a similar shift, characterized by increased expression of component of tight junctions, decreased cell‐to‐cell communication and downregulation of cell proliferation. These results indicate that ΔNp63 may contribute to esophageal squamous carcinogenesis by maintaining cell adhesion patterns compatible with cell proliferation.
The effect of a nanothickness coating on rough titanium substrate in the osteogenic properties of human bone cells
Authors: Moura Camilla C. G. , Souza Maria A. , Dechichi Paula , Zanetta‐Barbosa Darceny , Teixeira Cristina C. , Coelho Paulo G. 
Published: February 2010

AbstractThis study evaluated the effect of a bioactive ceramic coating, in the nanothickness range, onto a moderately rough surface on the osteogenic behavior of human bone cells. The cells were harvested from the mandibular mental region and were cultured over Ti‐6Al‐4V disks of different surfaces: as‐machined (M), alumina‐blasted/acid etched (AB/AE), and alumina‐blasted/acid‐etched + 300–500 nm thickness amorphous Ca‐ and P‐based coating obtained by ion beam‐assisted deposition (Nano). The culture was then evaluated regarding cell viability, adhesion, morphology, immunolocalization of osteopontin (OPN) and alkaline phosphatase (ALP). The results showed that the surface treatment did not interfere with cell viability. At 1 day, AB/AE and Nano showed higher adhesion than the M surface (p < 0.001). Higher adhesion was observed for the M than the Nano surface at 7 days (p < 0.005). The percentage of cells showing intracellular labeling for OPN at day 1 was significantly higher for the Nano compared to M surface (p < 0.03). The percentage of ALP intracellular labeling at 7 days was significantly higher for the AB/AE compared to the M surface (p < 0.0065); no differences were detected at 14 days. Our results suggest that the presence of a thin bioactive ceramic coating on a rough substrate did not favor the events related to in vitro osteogenesis. © 2010 Wiley Periodicals, Inc. J Biomed Mater Res, 2010
In vitro enzymatic biodegradation of adhesive resin in the hybrid layer
Authors: Zou Yuan , Jessop Julie L. P. , Armstrong Steven R. 
Published: February 2010

AbstractPenetration of adhesives into the demineralized dentin surface and their subsequent conversion are critically important to longevity of the adhesive resin (AR)‐dentin bond. The durability of the resin‐dentin bond is investigated by monitoring the change of adhesive concentration within the hybrid layer (HL) of aged specimens using Raman spectroscopy. Absolute molar concentrations of Bis‐GMA and HEMA were measured across the HL of resin‐dentin specimens 24 h after photopolymerization and after 24‐week storage in one of three media: artificial saliva (SAL), SAL containing cholesterol esterase to attack resin (EST), and SAL containing bacterial collagenase to attack collagen (COL). No significant difference among these groups for both Bis‐GMA and HEMA molar concentrations at 24‐h storage was found; however, concentrations decreased from the AR to the middle of the HL. Concentrations remained unchanged at any resin‐dentin position after aging in SAL. In the HL, concentrations significantly decreased with aging in COL and tended to decrease in EST. While showing potential enzymatic biodegradative effects of endogenous matrix metalloproteinases and salivary esterases, this methodology may also prove to be a valuable assessment of new chemistries and future approaches to improve resin‐dentin bond performance. © 2010 Wiley Periodicals, Inc. J Biomed Mater Res, 2010