bluuebunny/crossref_metadata_2025_split huggingface dataset:
A closer look in the mirror: reflections on the matter/dark matter coincidence
Authors: Bodas Arushi , Buen-Abad Manuel A. , Hook Anson , Sundrum Raman 
Published: June 2024

Abstract
We argue that the striking similarity between the cosmic abundances of baryons and dark matter, despite their very different astrophysical behavior, strongly motivates the scenario in which dark matter resides within a rich dark sector parallel in structure to that of the standard model. The near cosmic coincidence is then explained by an approximate ℤ2 exchange symmetry between the two sectors, where dark matter consists of stable dark neutrons, with matter and dark matter asymmetries arising via parallel WIMP baryogenesis mechanisms. Taking a top-down perspective, we point out that an adequate ℤ2 symmetry necessitates solving the electroweak hierarchy problem in each sector, without our committing to a specific implementation. A higher-dimensional realization in the far UV is presented, in which the hierarchical couplings of the two sectors and the requisite ℤ2-breaking structure arise naturally from extra-dimensional localization and gauge symmetries. We trace the cosmic history, paying attention to potential pitfalls not fully considered in previous literature. Residual ℤ2-breaking can very plausibly give rise to the asymmetric reheating of the two sectors, needed to keep the cosmological abundance of relativistic dark particles below tight bounds. We show that, despite the need to keep inter-sector couplings highly suppressed after asymmetric reheating, there can naturally be order-one couplings mediated by TeV scale particles which can allow experimental probes of the dark sector at high energy colliders. Massive mediators can also induce dark matter direct detection signals, but likely at or below the neutrino floor.
Black hole wavefunctions and microcanonical states
Authors: Chua Wan Zhen , Hartman Thomas 
Published: June 2024

Abstract
We consider the problem of defining a microcanonical thermofield double state at fixed energy and angular momentum from the gravitational path integral. A semiclassical approximation to this state is obtained by imposing a mixed boundary condition on an initial time surface. We analyze the corresponding boundary value problem and gravitational action. The overlap of this state with the canonical thermofield double state, which is interpreted as the Hartle-Hawking wavefunction of an eternal black hole in a mini-superspace approximation, is calculated semiclassically. The relevant saddlepoint is a higher-dimensional, rotating generalization of the wedge geometry that has been studied in two-dimensional gravity. Along the way we discuss a new corner term in the gravitational action that arises at a rotating horizon.
Spectral flow of fermions in the ℂP2 (anti-)instanton, and the sphaleron with vanishing topological charge
Authors: Amari Yuki , Sawado Nobuyuki , Yamamoto Shintaro 
Published: June 2024

Abstract
The spectral flow is ubiquitous in the physics of soliton-fermion interacting systems. We study the spectral flows related to a continuous deformation of background soliton solutions, which enable us to develop insight into the emergence of fermionic zero modes and the localization mechanism of fermion densities. We investigate a ℂP2 nonlinear sigma model in which there are the (anti-) instantons and also the sphalerons with vanishing topological charge. The standard Yukawa coupling of the fermion successfully generates infinite towers of the spectra and the spectral flow is observed when increasing the size of such solitons. At that moment, the localization of the fermions on the solitons emerges. The avoided crossings are also observed in several stages of the exchange of the flows, they are indicating a manifestation of the fermion exchange of the localizing nature.
Genomic and phenomic predictions help capture low-effect alleles promoting seed germination in oilseed rape in addition to QTL analyses
Authors: Laurençon Marianne , Legrix Julie , Wagner Marie-Hélène , Demilly Didier , Baron Cécile , Rolland Sophie , Ducournau Sylvie , Laperche Anne , Nesi Nathalie 
Published: June 2024

Abstract
Key message
Phenomic prediction implemented on a large diversity set can efficiently predict seed germination, capture low-effect favorable alleles that are not revealed by GWAS and identify promising genetic resources.

Abstract
Oilseed rape faces many challenges, especially at the beginning of its developmental cycle. Achieving rapid and uniform seed germination could help to ensure a successful establishment and therefore enabling the crop to compete with weeds and tolerate stresses during the earliest developmental stages. The polygenic nature of seed germination was highlighted in several studies, and more knowledge is needed about low- to moderate-effect underlying loci in order to enhance seed germination effectively by improving the genetic background and incorporating favorable alleles. A total of 17 QTL were detected for seed germination-related traits, for which the favorable alleles often corresponded to the most frequent alleles in the panel. Genomic and phenomic predictions methods provided moderate-to-high predictive abilities, demonstrating the ability to capture small additive and non-additive effects for seed germination. This study also showed that phenomic prediction estimated phenotypic values closer to phenotypic values than GEBV. Finally, as the predictive ability of phenomic prediction was less influenced by the genetic structure of the panel, it is worth using this prediction method to characterize genetic resources, particularly with a view to design prebreeding populations.
Low-temperature features of the psychrophilic chaperonin from Pseudoalteromonas haloplanktis
Authors: Hertle Eva , Ursinus Astrid , Martin Jörg 
Published: June 2024

AbstractChaperonins from psychrophilic bacteria have been shown to exist as single-ring complexes. This deviation from the standard double-ring structure has been thought to be a beneficial adaptation to the cold environment. Here we show that Cpn60 from the psychrophile Pseudoalteromonas haloplanktis (Ph) maintains its double-ring structure also in the cold. A strongly reduced ATPase activity keeps the chaperonin in an energy-saving dormant state, until binding of client protein activates it. Ph Cpn60 in complex with co-chaperonin Ph Cpn10 efficiently assists in protein folding up to 55 °C. Moreover, we show that recombinant expression of Ph Cpn60 can provide its host Escherichia coli with improved viability under low temperature growth conditions. These properties of the Ph chaperonin may make it a valuable tool in the folding and stabilization of psychrophilic proteins.
Moment-SoS methods for optimal transport problems
Authors: Mula Olga , Nouy Anthony 
Published: June 2024

AbstractMost common optimal transport (OT) solvers are currently based on an approximation of underlying measures by discrete measures. However, it is sometimes relevant to work only with moments of measures instead of the measure itself, and many common OT problems can be formulated as moment problems (the most relevant examples being $$L^p$$

L
p

-Wasserstein distances, barycenters, and Gromov–Wasserstein discrepancies on Euclidean spaces). We leverage this fact to develop a generalized moment formulation that covers these classes of OT problems. The transport plan is represented through its moments on a given basis, and the marginal constraints are expressed in terms of moment constraints. A practical computation then consists in considering a truncation of the involved moment sequences up to a certain order, and using the polynomial sums-of-squares hierarchy for measures supported on semi-algebraic sets. We prove that the strategy converges to the solution of the OT problem as the order increases. We also show how to approximate linear quantities of interest, and how to estimate the support of the optimal transport map from the computed moments using Christoffel–Darboux kernels. Numerical experiments illustrate the good behavior of the approach.
Intraoperative near infrared functional imaging of rectal cancer using artificial intelligence methods - now and near future state of the art
Authors: Boland Patrick A. , Hardy N. P. , Moynihan A. , McEntee P. D. , Loo C. , Fenlon H. , Cahill R. A. 
Published: June 2024

AbstractColorectal cancer remains a major cause of cancer death and morbidity worldwide. Surgery is a major treatment modality for primary and, increasingly, secondary curative therapy. However, with more patients being diagnosed with early stage and premalignant disease manifesting as large polyps, greater accuracy in diagnostic and therapeutic precision is needed right from the time of first endoscopic encounter. Rapid advancements in the field of artificial intelligence (AI), coupled with widespread availability of near infrared imaging (currently based around indocyanine green (ICG)) can enable colonoscopic tissue classification and prognostic stratification for significant polyps, in a similar manner to contemporary dynamic radiological perfusion imaging but with the advantage of being able to do so directly within interventional procedural time frames. It can provide an explainable method for immediate digital biopsies that could guide or even replace traditional forceps biopsies and provide guidance re margins (both areas where current practice is only approximately 80% accurate prior to definitive excision). Here, we discuss the concept and practice of AI enhanced ICG perfusion analysis for rectal cancer surgery while highlighting recent and essential near-future advancements. These include breakthrough developments in computer vision and time series analysis that allow for real-time quantification and classification of fluorescent perfusion signals of rectal cancer tissue intraoperatively that accurately distinguish between normal, benign, and malignant tissues in situ endoscopically, which are now undergoing international prospective validation (the Horizon Europe CLASSICA study). Next stage advancements may include detailed digital characterisation of small rectal malignancy based on intraoperative assessment of specific intratumoral fluorescent signal pattern. This could include T staging and intratumoral molecular process profiling (e.g. regarding angiogenesis, differentiation, inflammatory component, and tumour to stroma ratio) with the potential to accurately predict the microscopic local response to nonsurgical treatment enabling personalised therapy via decision support tools. Such advancements are also applicable to the next generation fluorophores and imaging agents currently emerging from clinical trials. In addition, by providing an understandable, applicable method for detailed tissue characterisation visually, such technology paves the way for acceptance of other AI methodology during surgery including, potentially, deep learning methods based on whole screen/video detailing.
Defining the optimal target-to-background ratio to identify positive lymph nodes in prostate cancer patients undergoing robot-assisted [99mTc]Tc-PSMA radioguided surgery: updated results and ad interim analyses of a prospective phase II study
Authors: Quarta Leonardo , Mazzone Elio , Cannoletta Donato , Stabile Armando , Scuderi Simone , Barletta Francesco , Cucchiara Vito , Nocera Luigi , Pellegrino Antony , Robesti Daniele , Leni Riccardo , Zaurito Paolo , Brembilla Giorgio , De Cobelli Francesco , Samanes Gajate Ana Maria , Picchio Maria , Chiti Arturo , Montorsi Francesco , Briganti Alberto , Gandaglia Giorgio 
Published: June 2024

Abstract
Introduction
Prostate-specific membrane antigen radioguided surgery (PSMA-RGS) might identify lymph node invasion (LNI) in prostate cancer (PCa) patients undergoing extended pelvic lymph node dissection (ePLND). The optimal target-to-background (TtB) ratio to define RGS positivity is still unknown.

Materials & methods
Ad interim analyses which focused on 30 patients with available pathological information were conducted. All patients underwent preoperative PSMA positron emission tomography (PET). 99m-Technetium-PSMA imaging and surgery ([99mTc]Tc-PSMA-I&S) was administered the day before surgery. In vivo measurements were conducted using an intraoperative gamma probe. Performance characteristics and implications associated with different TtB ratios were assessed.

Results
Overall, 9 (30%) patients had LNI, with 22 (13%) and 80 (11%) positive regions and lymph nodes, respectively. PSMA-RGS showed uptakes in 12 (40%) vs. 7 (23%) vs. 6 (20%) patients for a TtB ratio ≥ 2 vs. ≥ 3 vs. ≥ 4. At a per-region level, sensitivity, specificity and accuracy for a TtB ratio ≥ 2 vs. ≥ 3 vs. ≥ 4 were 72%, 88% and 87% vs. 54%, 98% and 92% vs. 36%, 99% and 91%. Performing ePLND only in patients with suspicious spots at PSMA PET (n = 7) would have spared 77% ePLNDs at the cost of missing 13% (n = 3) pN1 patients. A TtB ratio ≥ 2 at RGS identified 8 (24%) suspicious areas not detected by PSMA PET, of these 5 (63%) harbored LNI, with one pN1 patient (11%) that would have been missed by PSMA PET. Adoption of a TtB ratio ≥ 2 vs. ≥ 3 vs. ≥ 4, would have allowed to spare 18 (60%) vs. 23 (77%) vs. 24 (80%) ePLNDs missing 2 (11%) vs. 3 (13%) vs. 4 (17%) pN1 patients.

Conclusions
PSMA-RGS using a TtB ratio ≥ 2 to identify suspicious nodes, could allow to spare > 50% ePLNDs and would identify additional pN1 patients compared to PSMA PET and higher TtB ratios.
Navigated intraoperative ultrasound in pediatric brain tumors
Authors: Klein Gunnewiek Kevin , van Baarsen Kirsten M. , Graus Evie H. M. , Brink Wyger M. , Lequin Maarten H. , Hoving Eelco W. 
Published: June 2024

Abstract
Purpose
The aim of this study was to evaluate the diagnostic value and accuracy of navigated intraoperative ultrasound (iUS) in pediatric oncological neurosurgery as compared to intraoperative magnetic resonance imaging (iMRI).

Methods
A total of 24 pediatric patients undergoing tumor debulking surgery with iUS, iMRI, and neuronavigation were included in this study. Prospective acquisition of iUS images was done at two time points during the surgical procedure: (1) before resection for tumor visualization and (2) after resection for residual tumor assessment. Dice similarity coefficients (DSC), Hausdorff distances 95th percentiles (HD95) and volume differences, sensitivity, and specificity were calculated for iUS segmentations as compared to iMRI.

Results
A high correlation (R = 0.99) was found for volume estimation as measured on iUS and iMRI before resection. A good spatial accuracy was demonstrated with a median DSC of 0.72 (IQR 0.14) and a median HD95 percentile of 4.98 mm (IQR 2.22 mm). The assessment after resection demonstrated a sensitivity of 100% and a specificity of 84.6% for residual tumor detection with navigated iUS. A moderate accuracy was observed with a median DSC of 0.58 (IQR 0.27) and a median HD95 of 5.84 mm (IQR 4.04 mm) for residual tumor volumes.

Conclusion
We found that iUS measurements of tumor volume before resection correlate well with those obtained from preoperative MRI. The accuracy of residual tumor detection was reliable as compared to iMRI, indicating the suitability of iUS for directing the surgeon’s attention to areas suspect for residual tumor. Therefore, iUS is considered as a valuable addition to the neurosurgical armamentarium.

Trial registration number and date
PMCLAB2023.476, February 12th 2024.
Characterization of Cannabis users and products and the experience of negative mental emotions following Cannabis use
Authors: Treves Nir , Yakirevich-Amir Noa , Abu Ahmad Wiessam , Bonne Omer , Davidson Elyad , Keeling Keenan , Hall Branden , Dautrich Tyler , Matok Ilan 
Published: June 2024

AbstractThere is a potential link between cannabis and mental disorders﻿. Cannabis exposure involves in many cases negative mental emotions, which are unpleasant sensations or thoughts. Whereas mild cases of negative mental emotions inflict patient’s quality of life, more severe cases lead to therapy discontinuations, or even hospitalizations and death. This study characterizes cannabis users who experienced negative mental emotions after cannabis exposure. The Releaf App database was utilized to evaluate the association between personal and cannabis use characteristics on reporting a negative mental emotion during cannabis exposure. This global mobile lets individuals track real-time cannabis experience use with cannabinoid-based products, containing data points such as gender, age, reasons for use, product type, cannabis composition, and feelings and emotions experienced after cannabis use. Multivariable logistic regression models were constructed, adjusting for potential confounders such as gender and previous experience with cannabis use. The study population comprised 4,435 users, and 34,279 sessions were collected from various countries, mainly from North America, and included in the primary analysis. Reporting on negative mental emotions was associated with users in the age group of 18–30 years. Using cannabis for a mental purpose was associated with a small increase in reporting on negative mental emotions (OR = 1.10, 95%CI [1.03–1.19]). Oral products were associated with reporting on negative mental emotions. THC-dominant products were associated with reporting negative mental emotions compared to balanced products (OR = 1.21, 95%CI [1.06–1.38]). This study suggests that some characteristics of cannabis use, such as young age and oral consumption are associated with negative mental emotions. Further studies should examine the interface between cannabis consumption, characteristics of consumers, and negative emotional experience or even long-term mental disorders.
Prognosis and predictive factors of conversion surgery for initially unresectable advanced colorectal cancer
Authors: Ohira Gaku , Endo Satoshi , Imanishi Shunsuke , Tochigi Toru , Maruyama Tetsuro , Hayano Koichi , Maruyama Michihiro , Matsubara Hisahiro 
Published: June 2024

Abstract
Purpose
The aim of this study was to report the outcomes of conversion surgery for initially unresectable advanced colorectal cancer and to identify factors that enable successful conversion surgery.

Methods
We compared the outcomes of patients with colorectal cancer with distant metastases, including extrahepatic metastases, who underwent upfront surgery, neoadjuvant chemotherapy, conversion surgery, and chemotherapy only at our department from 2007 to 2020. In addition, factors influencing the achievement of conversion surgery in patients who were initially unresectable were examined in univariate and multivariate analyses.

Results
Of 342 colorectal cancer patients with distant metastases treated during the study period, 239 were judged to be initially unresectable, and 17 (conversion rate: 7.1%) underwent conversion surgery. The prognosis for the conversion surgery group was better than that of the chemotherapy only group but worse than that of the upfront surgery group. In the conversion surgery group, the recurrence-free survival after resection was significantly shorter than that upfront surgery group and neoadjuvant chemotherapy group, and no patients have been cured. Among patients who were initially unresectable, left-sided primary cancer and normal CA19-9 level were identified as independent factors contributing to the achievement of conversion surgery in a multivariate analysis.

Conclusions
Although relapse after conversion surgery is common, and no patients have been cured thus far, overall survival was better in comparison to patients who received chemotherapy only. Among unresectable cases, patients with left-sided primary cancer and normal CA19-9 levels are likely to be candidates for conversion surgery.
Cerebral fractional tissue oxygen extraction (cFTOE) during immediate fetal-to-neonatal transition: a systematic qualitative review of the literature
Authors: Schlatzer Christoph , Schwaberger Bernhard , Bruckner Marlies , Wolfsberger Christina Helene , Pichler Gerhard , Urlesberger Berndt , Baik-Schneditz Nariae 
Published: June 2024

AbstractCerebral monitoring during immediate fetal-to-neonatal transition is of increasing interest. The cerebral fractional tissue oxygen extraction (cFTOE) is a useful parameter to gain insight in the balance between tissue oxygen delivery and consumption during this complex process. The aim of this study was to review the literature on cFTOE during the first 15 min immediately after birth. A systematic qualitative literature research was last performed on 23 November 2023 of PubMed and EMBASE with the following search terms: neonate, infant, newborn, transition, after birth, delivery room, NIRS, near-infrared spectroscopy, spectroscopy, cFTOE, cerebral fractional tissue oxygenation extraction, cerebral oxygenation, and fractional oxygen extraction. Additional published reports were identified through a manual search of references in retrieved articles and in review articles. The methodological quality of the included studies was assessed by predefined quality criteria. Only human studies with data of cFTOE in the first 15 min after birth were included. Accordingly, exclusion criteria were defined as no measurement of cFTOE or no measurement within the first 15 min after birth. Across all studies, a total of 3566 infants (2423 term, 1143 preterm infants) were analysed. Twenty-five studies were identified describing cFTOE within the first 15 min after birth. Four studies established reference ranges for cFTOE and another four studies focused on the effect of pre-/perinatal circumstances on cFTOE in the first 15 min after birth. Six studies investigated the course of cFTOE after transition in infants without complications. Eleven studies analysed different potentially influencing parameters on cFTOE during transition. Conclusion: This systematic review provides a comprehensive insight on cFTOE during uncomplicated transition as well as the influence of perinatal circumstances, respiratory, haemodynamic, neurological, and laboratory parameters in preterm and term infants.

What is Known:

• The NIRS-measured cerebral fractional tissue oxygen extraction (cFTOE) is a useful parameter to estimate the balance between oxygen delivery and consumption. • During normal transition, the cFTOE decreases in the first minutes after birth and then remains at a stable plateau.

What is New:

• The cFTOE is a promising parameter that gives additional information on cerebral oxygenation and perfusion in preterm and term infants. • Several hemodynamic, metabolic, respiratory, and perinatal factors are identified, influencing the oxygen extraction of the newborn's brain after birth.