bluuebunny/crossref_metadata_2025_split huggingface dataset:
ESTRATÉGIAS COMUNICACIONAIS DE MARCAS PATROCINADORAS DAS SELEÇÕES DA COPA DO MUNDO 2018
Authors: Ghisleni Taís Steffenello , Cruz Júlia Oliveira Santos da 
Published: June 2024

O presente projeto analisa as estratégias de comunicação utilizadas pelas marcas que foram patrocinadoras das seleções participantes da Copa do Mundo de 2018 no Instagram, em junho e julho de 2018. Durante este período foi observada a frequência das postagens no Instagram das marcas Adidas e Nike, e foi feita a caracterização das postagens. As informações foram levantas através de uma pesquisa quali-quanti, utilizando a análise de conteúdo. Percebeu-se que cada marca utilizou uma estratégia diferente, além disso, houve um destaque para a Nike que contou com mais publicações.

PALAVRAS-CHAVE: Marketing esportivo; Estratégias de comunicação; Instagram; Patrocínio esportivo.

ABSTRACT
The present project analyzes the communication strategies used by the brands that sponsored the 2018 World Cup participants at Instagram in June and July 2018. During this period, the frequency of Instagram posts from the Adidas and Nike brands was observed, and the characterization of the posts was made. The information was raised through a quali-quanti survey, using content analysis. It was noticed that each brand used a different strategy, in addition, there was a highlight for Nike that featured more publications.

KEYWORDS: Sports marketing; Communication strategies; Instagram; Sports sponsorship.

RESUMEN
El presente proyecto analiza las estrategias de comunicación utilizadas por las marcas que fueron patrocinadoras de las selecciones participantes de la Copa del Mundo de 2018 en el Instagram en junio y julio de 2018. Durante este período se observó la frecuencia de las entradas en el Instagram de las marcas Adidas y Nike, y se hizo la caracterización de las entradas. Las informaciones fueron levantas a través de una encuesta cuali-quanti, utilizando el análisis de contenido. Se percibió que cada marca utilizó una estrategia diferente, además, hubo un destaque para Nike que contó con más publicaciones.

PALABRAS CLAVE: Marketing deportivo; Estrategias de comunicación; Instagram; Patrocinio deportivo.
MICROCRÉDITO E (DES) EMPODERAMENTO DAS MULHERES BENEFICIÁRIAS NO BANCO DO POVO EM PALMAS /TO
Authors: Parente Temis Gomes , Coelho Eliene Campelo 
Published: June 2024

O microcrédito tem sido adotado em diversos países como uma ferramenta capaz de gerar renda, reduzir desigualdades sociais e empoderar mulheres. Neste contexto, com foco na perspectiva de gênero, o presente artigo tem como objetivo analisar se o microcrédito contribuiu para o empoderamento de mulheres beneficiárias do Banco do Povo em Palmas/Tocantins. A metodologia adotada é a História Oral que desnuda redes do cotidiano das beneficiárias, que lhes dá voz e traz à tona processos desencadeados a partir do microcrédito. Os depoimentos evidenciam que, apesar de o microcrédito trazer melhorias nas condições de vida, o empoderamento destas clientes não foi alcançado no sentido de dar-lhes condições de emancipação, autonomia, participação social, autoestima e formação educacional.

PALAVRAS-CHAVE: Microcrédito; Perspectiva de gênero; Empoderamento; Desempoderamento; Banco do Povo.

ABSTRACT
Microcredit has been adopted in several countries as a tool capable of generating income, reducing social inequalities and empowering women. In this context, focusing on the gender perspective, this article aims to analyze whether microcredit contributed to the empowerment of women beneficiaries of the People's Bank in Palmas / Tocantins. The methodology adopted is the Oral History that bares networks of beneficiaries' daily life, which gives them voice and brings to the fore processes triggered by microcredit. The testimonies show that, although microcredit brings improvements in living conditions, the empowerment of these clients was not achieved in the sense of giving them conditions of emancipation, autonomy, social participation, self-esteem and educational training.

KEYWORDS: Microcredit; Gender perspective; Empowerment; Deforestation; Bank of the People.

RESUMEN
El microcrédito ha sido adoptado en diversos países como una herramienta capaz de generar ingresos, reducir desigualdades sociales y empoderar a mujeres. En este contexto, con foco en la perspectiva de género, el presente artículo tiene como objetivo analizar si el microcrédito contribuyó para el empoderamiento de mujeres beneficiarias del Banco del Pueblo en Palmas / Tocantins. La metodología adoptada es la Historia Oral que desnuda redes de lo cotidiano de las beneficiarias, que les da voz y trae a la luz procesos desencadenados a partir del microcrédito. Los testimonios evidencian que, a pesar de que el microcrédito trae mejoras en las condiciones de vida, el empoderamiento de estas clientes no fue alcanzado en el sentido de darles condiciones de emancipación, autonomía, participación social, autoestima y formación educativa.

PALABRAS CLAVE: Microcrédito; Perspectiva de género; empoderamiento; pérdida de poder; Banco del Pueblo.
EDUCAÇÃO A DISTÂNCIA DA UFT/UAB NA PERCEPÇÃO DOS DISCENTES
Authors: Faria Denilda Caetano de , Alves Elaine Jesus , Nunes Suzana Gilioli da Costa 
Published: June 2024

O artigo versa sobre os cursos de formação a distância ofertados pela Universidade Federal do Tocantins- UFT via Sistema Universidade Aberta do Brasil no Estado do Tocantins. Teve como objetivo revelar as percepções dos discentes dos cursos, em relação a modalidade a distância, mais especificamente, quanto às suas experiências pessoais das práticas educativas, no âmbito pedagógico e organizacional. Os dados foram coletados por meio de questionários. Os resultados do estudo evidenciaram a importância da oferta dos cursos EaD via UFT/UAB como oportunidade de aprimoramento profissional dos discentes; a autonomia do aprendente e flexibilidade do Ambiente Virtual de Aprendizagem; os recursos de interação, fórum e chat, promovendo trocas de saberes; o apoio da tutoria no processo de ensino aprendizagem; a ausência dos professores das disciplinas.

PALAVRAS-CHAVE: UAB; discente; EaD; UFT.

ABSTRACTThe article deals with the distance training courses offered by the Federal University of Tocantins - UFT in Open University System of Brazil in the State of Tocantins. It aimed to reveal the perceptions of the students of the courses, in relation to the distance modality, more specifically, their personal experiences of educational practices, in the pedagogical and organizational context. Data were collected through questionnaires. The results of the study evidenced the importance of offering the EaD courses via UFT/ UAB as an opportunity for professional improvement of students; the autonomy of the learner and the flexibility of the Virtual Learning Environment; the interaction resources, forum and chat, promoting exchanges of knowledge; mentoring support in the teaching-learning process; the absence of the teachers of the disciplines.

KEYWORDS: UAB; student; perceptions; EaD; UFT.

RESUMEN
El artículo trata sobre los cursos de capacitación a distancia que ofrece la Universidad Federal de Tocantins - UFT a través del Sistema Aberta do Brasil en el estado de Tocantins. Su objetivo era revelar las percepciones de los estudiantes de los cursos, en relación con la modalidad a distancia, más específicamente, sus experiencias personales de prácticas educativas, en el contexto pedagógico y organizativo. Los datos fueron recolectados a través de cuestionarios. Los resultados del estudio evidenciaron la importancia de ofrecer los cursos EaD a través de UFT / UAB como una oportunidad para el mejoramiento profesional de los estudiantes; la autonomía del alumno y la flexibilidad del entorno de aprendizaje virtual; Los recursos de interacción, foro y chat, promoviendo el intercambio de conocimientos. apoyo de mentoría en el proceso de enseñanza-aprendizaje; La ausencia de los maestros de las disciplinas.

PALABRAS CLAVE: UAB; estudiante EaD; UFT.
TÁCTICAS DE MARKETING Y COMUNICACIÓN POLÍTICA EN LA ERA POSMODERNA: El Bono de Empleo Joven 2013 de la Junta de Andalucía
Authors: Gallardo Vera Luis , Micaletto Belda Juan Pablo 
Published: June 2024

RESUMEN
En las sociedades actuales, las acciones de marketing y comunicación políticas se orientan a promover las clases sociales dominantes. En esta línea, la Junta de Andalucía implantó la primera versión del programa Bono de Empleo Joven en 2013. El objetivo general de la investigación fue determinar si el programa implicó una acción de marketing y comunicación política, con la hipótesis principal, confirmada, de que el programa supuso una acción de este tipo, pero estratégicamente inadecuada. Se analizaron 20 mensajes publicados en las ediciones digitales de los periódicos de mayor audiencia en Andalucía.

PALABRAS CLAVE: Comunicación institucional, sociedad posmoderna, hegemonía, comunicación política, persuasión.

RESUMO
Nas sociedades atuais, o marketing político e as ações de comunicação são orientadas para promover as classes sociais dominantes. Nesta linha, a Junta de Andalucía implementou a primeira versão do programa Bônus de Emprego Jovem em 2013. O objetivo geral da pesquisa foi determinar se o programa envolveu uma ação de marketing e comunicação política, com a principal hipótese, confirmada, de que o programa implicou uma ação deste tipo, mas estratégicamente inadequada. Forman analisados 20 mensagens publicadas nas edições digitais dos jornais com maior audiência em Andalucía.

PALAVRAS-CHAVE: Comunicação institucional, sociedade pós-moderna, hegemonia, comunicação política, persuasão.

ABSTRACT
In current societies, marketing and communicative policies actions are oriented toward promoting the dominant social classes. According to that idea, the Andalussian Goverment created the first version of the programme Young Employment Bonus (Bono de Empleo Joven) in 2013. The main objective was to determinate if this new programme supossed a marketing and communicative policy action or not. This main hypotesis was confirmed, however it was strategically unsuitable. There were analized 20 messages which were published in the digital editions of the main newspapers in Andalusia.

KEYWORDS: Institutional communication, postmodern society, supremacy, communicative policy, persuasión.
Study on Cloning and Expression of TNF-α Variants in E. coli:
Production, Purification, and Interaction with Anti-TNF-α Inhibitors
Authors: Akçadağ Gülşah , Cansaran-Duman Demet , Aras Emine Sümer , Ataoğlu Haluk 
Published: June 2024

Background:
TNF-α is a proinflammatory cytokine and plays a role in cell proliferation,
differentiation, survival, and death pathways. When administered at high doses, it may cause
damage to the tumor vasculature, thereby increasing the permeability of the blood vessels. Therefore,
monitoring the dose and the response of the TNF-α molecule is essential for patients' health

Objectives:
This study aimed to clone, express, and purify the active form of the TNF-α protein,
which can interact with various anti-TNF-α inhibitors with high efficiency.

Methods:
Recombinant DNA technology was used to clone three different versions of codon-optimized
human TNF-α sequences to E. coli. Colony PCR protocol was used for verification and produced
proteins were analyzed through SDS-PAGE and western blot. Size exclusion chromatography
was used to purify sTNF-α. ELISA techniques were used to analyze and compare binding efficiency
of sTNF-α against three different standards.

Results:
Under native condition (25°C), interaction between sTNF-α and anti-TNF-α antibody
was 3,970, compared to positive control. The interaction was 0,587, whereas it was 0,535 for TNF-
α and anti-TNF-α antibodies under denaturing conditions (37°C). F7 of sTNF-α (920 μg/mL)
had the same/higher binding efficiency to adalimumab, etanercept, and infliximab, compared to
commercial TNF-α.

Conclusion:
This study was the first to analyze binding efficiency of homemade sTNF-α protein
against three major TNF-α inhibitors (adalimumab, etanercept, and infliximab) in a single study.
The high binding efficiency of sTNF-α with adalimumab, etanercept, and infliximab, evidenced in
this study supports the feasibility of its use in therapeutic applications, contributing to more sustainable,
cost-effective, and independent healthcare system.
Synthesis and Anti-gastric Cancer Activity by Targeting FGFR1 Pathway of Novel Asymmetric Bis-chalcone Compounds
Authors: Nian Chunhui , Gan Xin , Liu Qunpeng , Wu Yuna , Kong Miaomiao , Zhang Peiqin , Jin Mingming , Dong Zhaojun , Li Wulan , Wang Ledan , He Wenfei , Li Xiaokun , Wu Jianzhang 
Published: June 2024

Background:
Bis-chalcone compounds with symmetrical structures, either isolated from natural
products or chemically synthesized, have multiple pharmacological activities. Asymmetric Bis-chalcone
compounds have not been reported before, which might be attributed to the synthetic challenges involved,
and it remains unknown whether these compounds possess any potential pharmacological activities.

Aims:
The aim of this study is to investigate the synthesis route of asymmetric bis-chalcone compounds
and identify potential candidates with efficient anti-tumor activity.

Methods:
The two-step structural optimization of the bis-chalcone compounds was carried out sequentially,
guided by the screening of the compounds for their growth inhibitory activity against gastric cancer
cells by MTT assay. The QSAR model of compounds was established through random forest (RF)
algorithm. The activities of the optimal compound J3 on growth inhibition, apoptosis, and apoptosis-inducing
protein expression in gastric cancer cells were investigated sequentially by colony formation assay,
flow cytometry, and western blotting. Further, the inhibitory effects of J3 on the FGFR1 signaling
pathway were explored by Western Blotting, shRNA, and MTT assays. Finally, the in vivo anti-tumor
activity and mechanism of J3 were studied through nude mice xenograft assay, western blotting.

Results:
27 asymmetric bis-chalcone compounds, including two types (N and J) were sequentially designed
and synthesized. Some N-class compounds have good inhibitory activity on the growth of gastric
cancer cells. The vast majority of J-class compounds optimized on the basis of N3 exhibit excellent inhibitory
activity on gastric cancer cell growth. We established a QSAR model (R2 = 0.851627) by applying
random forest algorithms. The optimal compound J3, which had better activity, concentration-dependently
inhibited the formation of gastric cancer cell colonies and led to cell apoptosis by inducing the expression
of the pro-apoptotic protein cleaved PARP in a dose-dependent manner. J3 may exert anti-gastric
cancer effects by inhibiting the activation of FGFR1/ERK pathway. Moreover, at a dose of 10
mg/kg/day, J3 inhibited tumor growth in nude mice by nearly 70% in vivo with no significant toxic effect
on body weight and organs.

Conclusion:
In summary, this study outlines a viable method for the synthesis of novel asymmetric bischalcone
compounds. Furthermore, the compound J3 demonstrates substantial promise as a potential
candidate for an anti-tumor drug.
Determination of Inhibitory Effect of PKM2 Enzyme and Antitumoral Activity of Novel Coumarin-naphthoquinone Hybrids
Authors: de Andrade Borges Amanda , Ouverney Gabriel , Arruda Afonso Thales Sousa , Ribeiro Amanda Vieira , Ribeiro Ruan Carlos Busquet , de Souza Acacio Silva , da Fonseca Anna Carolina Carvalho , de Queiroz Lucas Nicolau , de Almeida Elan Cardozo Paes , Pontes Bruno , Rabelo Vitor Won-Held , Ferreira Vitor , Abreu Paula Alvarez , de Carvalho da Silva Fernando , da Silva Magalhaes Forezi Luana , Robbs Bruno Kaufmann 
Published: June 2024

Background:
Oral squamous cell carcinoma (OSCC) represents the primary form of
oral cancer, posing a significant global health threat. The existing chemotherapy options are accompanied
by notable side effects impacting patient treatment adherence. Consequently, the exploration
and development of novel substances with enhanced anticancer effects and fewer
side effects have become pivotal in the realms of biological and chemical science.

Objective:
This work presents the pioneering examples of naphthoquinone-coumarin hybrids
as a new category of highly effective cytotoxic substances targeting oral squamous cell carcinoma
(OSCC).

Methods:
Given the significance of both naphthoquinones and coumarins as essential pharmacophores/
privileged structures in the quest for anticancer compounds, this study focused on the
synthesis and evaluation of novel naphthoquinones/coumarin hybrids against oral squamous
cell carcinoma.

Results:
By several in vitro, in silico, and in vivo approaches, we demonstrated that compound
6e was highly cytotoxic against OSCC cells and several other cancer cell types and was more
selective than current chemotherapeutic drugs (carboplatin) and the naphthoquinone lapachol.
Furthermore, compound 6e was non-hemolytic and tolerated in vivo at 50 mg/kg with an LD50
of 62.5 mg/kg. Furthermore, compound 6e did not induce apoptosis and cell cycle arrest but
led to intracellular vesicle formation with LC3 aggregation in autophagosomes, suggesting an
autophagic cell death. Additionally, 6e had a high-affinity potential for PKM2 protein, higher
than the known ligands, such as lapachol or shikonin, and was able to inhibit this enzyme activity
in vitro.

Conclusion:
We assert that compound 6e shows promise as a potential lead for a novel chemotherapeutic
drug targeting OSCC, with potential applicability to other cancer types.
An Integrative Network Pharmacology and Bioinformatics Approach for Deciphering the Multi-target Effect of Nyctanthes arbortristis L. against COVID-19
Authors: Sreeharsha Nagaraja , Basavarajappa Girish Meravanige , Aloufi Bandar , Shiroorkar Predeepkumar Narayanappa , Anwer Md. Khalid , Rehman Abdur 
Published: June 2024

Introduction:
The COVID-19 pandemic represents a significant challenge across scientific, medical,
and societal dimensions. The unpredictability of the disease progression, caused by the severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2), underscores the urgent need for identifying compounds that
target multiple aspects of the virus to ensure swift and effective treatment. Nyctanthes arbortristis L., a delicate,
perennial, deciduous shrub found across various Asian regions, has been recognized for its wide range of
pharmacological benefits, including hepatoprotective, antimalarial, antibacterial, anti-inflammatory, antioxidant,
and antiviral properties.

Methods:
Various in vitro studies revealed the therapeutic significance of Nyctanthes arbortristis against
COVID-19. However, the exact molecular mechanism remains unclarified. In the present study, a network
pharmacology approach was employed to uncover the active ingredients, their potential targets, and signaling
pathways in Nyctanthes arbortristis for the treatment of COVID-19. In the framework of this study, we explored
the active ingredient–target–pathway network and figured out that naringetol, ursolic acid, betasitosterol,
and daucosterol decisively contributed to the development of COVID-19 by affecting IL6, MAPK3,
and MDM2 genes.

Results:
The results of molecular docking analysis indicated that Nyctanthes arbortristis exerted effective
binding capacity in COVID-19. Further, we disclosed the targets, biological functions, and signaling pathways
of Nyctanthes arbortristis in COVID-19. The analysis indicated that Nyctanthes arbortristis could help treat
COVID-19 through the enhancement of immunologic functions, inhibition of inflammatory reactions and regulation
of the cellular microenvironment. In short, the current study used a series of network pharmacologybased
and computational analyses to understand and characterize the binding capacity, biological functions,
pharmacological targets and therapeutic mechanisms of Nyctanthes arbortristis in COVID-19.

Conclusion:
However, the findings were not validated in actual COVID-19 patients, so further investigation
is needed to confirm the potential use of Nyctanthes arbortristis for treating COVID-19.
The Effect of Ginseng Supplementation on Lipid Profile: GRADE-assessed
Systematic Review and Dose-response Meta-analysis of Randomized Controlled
Trials
Authors: Arabi Seyyed Mostafa , Shahraki-Jazinaki Mostafa , Nayyer Abadi Maryam , Bahrami Leila Sadat , Chambari Mahla , Bahari Hossein , Sahebkar Amirhossein 
Published: June 2024

Background:
This systematic review and meta-analysis aimed to evaluate the overall impact of Panax
ginseng on lipid profile by synthesizing existing evidence. Cardiovascular Disease (CVD) is the leading
cause of morbidity and mortality among the elderly population, and serum lipids play a crucial role in its development.
Maintaining optimal levels of triglycerides, high-density lipoprotein cholesterol, low-density lipoprotein
cholesterol, and total cholesterol is essential in reducing the risk of CVD. Ginsenosides, the active constituents
in ginseng, have shown positive effects on lipid metabolism. This review aimed to provide a comprehensive
understanding of the potential benefits of ginseng in managing dyslipidemia, which could have significant
implications for the prevention and treatment of CVD.

Methods:
A comprehensive analysis of 29 Randomized Controlled Trials (RCTs) was conducted to assess the
effects of ginseng supplementation on lipid profile, including Triglyceride (TG), Total Cholesterol (TC),
High-density Lipoprotein Cholesterol (HDL-C), and Low-density Lipoprotein Cholesterol (LDL-C) levels. A
systematic search was done in online databases, such as MEDLINE, Scopus, and Clarivate Analytics Web of
Science, using relevant keywords and MeSH terms to identify relevant studies until January 2024.

Results:
The Weighted Mean Differences (WMD) and 95% Confidence Intervals (CI) for TG, TC, LDL-C,
and HDL-C did not show significant changes with ginseng supplementation.

Conclusion:
Taking into account the results, using ginseng did not have a statistically significant influence on
lipid profile parameters in individuals with different health conditions. Further, well-designed RCTs focusing
on specific diseases are needed to clarify the potential beneficial effects of ginseng and its derivatives on lipid
profile.
Pharmacological Mechanism of Herbal Interventions for Bipolar Disorder
Authors: Singh Abhinav , Sarwat Maryam , Gupta Sangeetha 
Published: June 2024

:
Bipolar disorder is a neuropsychiatric disease characterized by an abundance of undesired ideas and
thoughts associated with recurrent episodes of mania or hypomania and depression. Alterations in the circuits,
including the prefrontal cortex, striatum, and limbic system, regulate mood and cause variation in several crucial
neurotransmitters, including serotonin, dopamine, GABA, and glutamate. Imbalances in dopamine levels
have been implicated in the manic phase, while variance in serotonin is linked to depressive episodes. The precise
pathophysiology of bipolar disorder is still unknown. Though different treatments are available, like lithium,
risperidone, valproic acid, etc., which are widely used, they come with certain limitations, including narrow
therapeutic index, hypothyroidism, weight gain, extrapyramidal symptoms, etc. The interest in herbal-
based treatments for bipolar disorder arises from the desire for alternative, potentially more natural, and
holistic approaches with fewer side effects. The current review focuses on the potential effects of herbal drugs
and their derivatives to alleviate the symptoms of bipolar disorder.