bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association of Timing of Hindfoot Arthrodesis and Early Reoperation Rates for Total Ankle Arthroplasty
Authors: Ramamurti Pradip , Schwartz Joshua M. , Novicoff Wendy M. , Park Joseph S. , Cooper Minton T. 
Published: May 2024

Background: Prior literature has demonstrated that ipsilateral hindfoot arthrodesis may increase the risk for reoperation after total ankle arthroplasty (TAA) and that simultaneous hindfoot arthrodesis with TAA could result in short-term clinical and radiologic improvements. The purpose of this study is to compare the reoperation rates after TAA with prior hindfoot arthrodesis vs simultaneous arthrodesis and TAA. Methods: Patients who underwent primary TAA were identified in the PearlDiver database. Patients were sorted into 2 study cohorts: hindfoot arthrodesis prior to TAA and simultaneous arthrodesis and TAA. Propensity matched control cohorts were identified for each study group. Multivariate analysis was conducted to account for any confounding variables and covariates when identifying differences in complications between cohorts. Results: 297 patients underwent TAA with prior hindfoot arthrodesis and 174 underwent TAA and hindfoot arthrodesis concurrently. The incidence of reoperation (13.8% vs 5.2%, P  < .001) and infection (12.6% vs 5.9%, P  = .011) for the simultaneous cohort was higher when compared to the matched control cohort. In contrast, there was no statistically significant difference when comparing the prior arthrodesis cohort to the matched control cohort in reoperation rates (5.1% vs 4.7%, P  = .787) or infection rates (4.4% vs 4.8%, P  = .734). Those undergoing simultaneous procedures had increased incidences of reoperation, wound complications, infection, and emergency department visits ( P  < .0167) when compared to the TAA with prior arthrodesis cohort. Conclusion: Patients undergoing TAA and hindfoot arthrodesis concurrently were found to have higher rates of reoperation and infection when compared to the matched control cohort . In contrast, there was no difference in these rates in patients undergoing TAA with prior hindfoot arthrodesis compared with their matched control cohort. Patients undergoing simultaneous procedures had increased rates of reoperations, wound complications, infection, and emergency department visits compared to the TAA with prior arthrodesis cohort.
Development of a Prandtl-Ishlinskii hysteresis model for a large capacity magnetorheological fluid damper
Authors: Vatandoost Hossein , Abdalaziz Moustafa , Sedaghati Ramin , Rakheja Subhash 
Published: May 2024

Magnetorheological (MR) fluid (MRF) dampers, serving as fail-safe semi-active devices, exhibit nonlinear hysteresis characteristics, emphasizing the necessity for accurate modeling to formulate effective control strategies in smart systems. This paper introduces a novel stop operator-based Prandtl-Ishlinskii (PI) model, featuring a reduced parameter set (seven), designed to estimate the nonlinear hysteresis properties of a large-scale bypass MRF damper with variable stiffness capabilities under varying applied current. With only seven parameters, the model realizes current, displacement, and rate dependencies. The force-displacement and force-velocity responses of the designed MRF damper were experimentally characterized under broad ranges of applied current (0–2 A), excitation frequency (0.5–4 Hz), and displacement amplitude (1–2.5 mm). A training dataset was subsequently used to develop a novel field-dependent modified PI model, incorporating multiple hysteresis operators with and without a friction element. The proposed model accurately predicted the MRF damper behavior within the training dataset, and its validity was assessed against data from diverse experimental conditions. The PI model with friction element generally outperformed the model without friction when frequency exceeds 0.5 Hz, demonstrating its ability to characterize nonlinear hysteresis force-displacement and force-velocity properties of the MRF damper under the ranges of applied current and excitations considered with reasonable accuracy. Experimental data were also estimated by the Bouc–Wen model, and compared with those obtained via the formulated PI model, affirming the overall superiority of the proposed PI models considering the computational cost, and total number of parameters. Leveraging the simplicity, minimal parameter requirements, and analytic invertibility of PI models, the proposed PI model is considered a superior choice for modeling and subsequently controlling smart structures employing MRF dampers.
Home Health Nurses’ Perceptions of Caring for Persons With Severe and Persistent Mental Illnesses
Authors: Riley Kiernan , Hupcey Judith E. 
Published: May 2024

BACKGROUND: Severe and persistent mental illnesses (SPMIs) affect a significant portion of the adult population in the United States. Despite their increased medical disease burden, individuals with SPMIs often lack access to appropriate medical care. Home health services offer cost-effective options for caring for this population in the comfort of their homes. However, little is known about the perceptions of home health nurses providing care to persons with SPMIs, and how they are adjusting care to persons with SPMIs AIMS: This study aimed to explore home health nurses’ perspectives on caring for persons with SPMIs. METHODS: Using a grounded theory approach, individual semi-structured interviews were conducted with home health and home hospice nurses. The research questions focused on the nurses’ experiences, barriers and facilitators to care, and the impact of the home environment on caring for persons with SPMIs. Data analysis followed coding procedures outlined in grounded theory, resulting in the development of an axial coding model. RESULTS/CONCLUSIONS: The findings provide valuable insights into the challenges and opportunities faced by home health nurses when providing care for individuals with SPMIs. The outcomes of this study are intended to contribute to the understanding of current care practices and can guide the allocation of resources to improve care for this vulnerable population, such as incorporating training specific to persons with severe psychiatric illnesses.
Does income matter for the policy effect of public long-term care insurance on informal care use in China? A quasi-experimental study
Authors: Ning Jing , Chen He , Li Man 
Published: May 2024

Objective Since 2016, the Chinese government has been piloting a public long-term care insurance (LTCI) scheme. This study examined whether the LTCI scheme reduced the use of informal care and how this has varied across income groups. Method We used data from the 2011, 2014, and 2018 waves of Chinese Longitudinal Healthy Longevity Survey, focusing on community-dwelling older adults aged 65 years and older. We used staggered difference-in-differences analyses with propensity score matching to examine the effects of the policy. Results The LTCI scheme reduced the probability and intensity of informal care use by 5.7% ( p < .05) and 17.4% ( p < .05), respectively. The policy impact was limited to older people in the middle-income group, reducing the probability and intensity of informal care use by 15.6% ( p < .001) and 43.1% ( p < .05), respectively. We did not find a statistically significant policy effect for older adults with high or low incomes. Conclusions The LTCI scheme had different effects on reducing the informal care burden for family caregivers by income level. We suggest that the scheme should entitle people with low incomes to a preferential co-payment rate, thereby enhancing their access to formal care.
Early single-center experience with middle meningeal artery embolization using Zoom™ 45 Catheter
Authors: Morsi Rami Z , Thind Sonam , Baskaran Archit , Rana Rohini , Carrión-Penagos Julián , Desai Harsh , Kothari Sachin A , Chahine Ahmad , Zakaria Jehad , Polster Sean P , Siegler James E , Mendelson Scott J , Mansour Ali , Hurley Michael C , Prabhakaran Shyam , Kass-Hout Tareq 
Published: May 2024

Background Middle meningeal artery (MMA) embolization for subdural hematomas (SDH) and dural arteriovenous fistulas (dAVFs) has gained momentum in the neuroendovascular space. However, there is variability in the technique for safe and effective embolization. The aim of this report is to describe the technical feasibility and clinical performance of using Zoom™ 45 catheter for MMA access to facilitate embolization. Methods We analyzed all cases of MMA embolization in which the Zoom™ 45 catheter was used and performed in our institution from February 2021 to March 2023 for SDH and dAVFs. Results A total of 32 patients were included. Mean age was 64.0 ± 18.0 years, 75.0% (4/32) were male, and 56.7% (17/30), were black. The technical success was achieved in 93.8% (30/32) of cases, with selective embolization utilizing microcatheter directly into frontal and parietal branches for most patients (96.9%, 31/32). Identification of dangerous collaterals, such as lacrimal and petrous branches, prior to embolization, was achieved in most patients (96.9%, 31/32). Bilateral MMA embolization was done in 50.0% (16/32) of patients. The transradial approach and transfemoral approach were used in 53.1% (17/32) and 46.9% (15/32) of patients, respectively. The most common embolization material was n-butyl cyanoacrylate (84.4%, 27/32). There were no access site complications or complications related to the MMA embolization procedures and used devices. Conclusions The use of Zoom™ 45 Catheter seems to be technically feasible, safe, and effective for facilitating MMA access for embolization in the context of SDH and dAVFs.
Ocular surface complications in children undergoing general anaesthesia: A prospective observational study
Authors: El Hadi Dalia , Hoyeck Stephanie , Rachid Elza , El Moussawi Zeinab , Torbey Julien , Aouad Marie , Al-Haddad Christiane 
Published: May 2024

Objective: Ophthalmic complications frequently occur after procedures requiring general anaesthesia, but their incidence is widely variable and not well reported in the paediatric population. The aim was to identify the incidence and possible risk factors of postoperative ocular surface complications in a tertiary care centre. Methods and Analysis: This is a prospective study for paediatric patients undergoing general anaesthesia. An ophthalmologist performed the ocular examination after surgery. Parameters assessed were tear breakup time, punctate epithelial erosions and corneal abrasions. Multivariate logistic regression model was used to assess risk factors. Results: A total of 108 paediatric patients were recruited, 36.1% showed abnormal corneal finding: 32 (29.6%) had decreased tear breakup time, three (2.7%) had punctate epithelial erosions, three (2.7%) had both punctate epithelial erosions and decreased tear breakup time and one (0.9%) was found to have a unilateral corneal abrasion postoperatively. A higher rate of corneal complications was noted with younger age, prolonged surgery and surgery in the head and neck region. Conclusion: The rate of postoperative corneal abnormalities in children undergoing general anaesthesia was 36.1%, associated with younger age, prolonged surgery and surgery in the head and neck region.
An ecosystem of accepting life with chronic pain: A meta-ethnography
Authors: Macgregor Cassandra , Blane David N , Tulle Emmanuelle , Campbell Claire L , Barber Ruth J , Hill O-Connor Clementine , Seenan Christopher 
Published: May 2024

Background Chronic pain is a highly prevalent long-term condition, experienced unequally, impacting both the individual living with pain, and wider society. ‘Acceptance’ of chronic pain is relevant to improved consultations in pain care, and navigating an approach towards evidence-based, long-term management and associated improvements in health. However, the concept proves difficult to measure, and primary qualitative studies of lived experiences show complexity related to our socio-cultural-political worlds, healthcare experiences, and difficulties with language and meaning. We framed acceptance of chronic pain as socially constructed and aimed to conceptualise the lived experiences of acceptance of chronic pain in adults. Methods We conducted a systematic search and screening process, followed by qualitative, interpretive, literature synthesis using Meta-ethnography. We included qualitative studies using chronic pain as the primary condition, where the study included an aim to research the acceptance concept. We conducted each stage of the synthesis with co-researchers of differing disciplinary backgrounds, and with lived experiences of chronic pain. Findings We included 10 qualitative studies from Canada, Sweden, The Netherlands, Ireland, UK, Australia and New Zealand. Our ‘lines of argument’ include a fluid and continuous journey with fluctuating states of acceptance; language and meaning of acceptance and chronic pain, a challenge to identity in a capitalist, ableist society and the limits to individualism; a caring, supportive and coherent system. The conceptual framework of the meta-ethnography is represented by a rosebush with interconnected branches, holding both roses and thorns, such is the nature of accepting life with chronic pain. Conclusion Our findings broaden conceptualisation of ‘acceptance of chronic pain’ beyond an individual factor, to a fluid and continuous journey, interconnected with our socio-cultural-political worlds; an ecosystem.
Efficacy of Benson's Relaxation Technique on Stress and Pain Among Patients Undergoing Maintenance Hemodialysis: A Systematic Review
Authors: Abu Maloh Haya Ibrahim Ali , Soh Kim Lam , Chong Seng Choi , Ismail Siti Irma Fadhilah , Soh Kim Geok , Abu Maloh Dima Ibrahim , AbuRuz Mohannad Eid 
Published: May 2024

Introduction Stress and pain are high among patients undergoing hemodialysis. Benson's Relaxation technique affected a wide range of physical and psychological signs and symptoms among patients undergoing hemodialysis. Objective To evaluate the effectiveness of Benson's Relaxation Technique in reducing stress and pain among patients undergoing maintenance hemodialysis. Materials and Methods A systematic review of randomized controlled trials was conducted. A systematic literature search was carried out from 2000 to 2023. Searched databases included EBSCO-Host “Academic Search, Cochrane, CINAHL, Health Business, MEDLINE, Psychology and Behavioral Sciences, SPORTDiscus”, PubMed, Ovid, and Google Scholar. The Preferred Reporting Items for Systematic Review and Meta-Analysis guidelines were conducted. RCTs were critically appraised using the Cochrane's Risk of Bias Tool. Four RCTs met the inclusion criteria and included in this review since they were applicable to practice. Results Four randomized controlled trials were identified supporting the use of Benson's relaxation technique as a nursing treatment in managing stress and pain among patients undergoing maintenance hemodialysis, as it achieved a significant decrease in stress and pain scores. The overall quality of the randomized controlled trials was judged to be low to relatively moderate. Conclusions Most of the randomized controlled trials lacked details on intervention adherence. It is recommended to conduct additional longitudinal randomized controlled trials in different countries with bigger sample sizes, to provide more evidence for generalizing outcomes.
Epidemiology of transient ischemic attack in the Normandy Stroke population-based study
Authors: Schneckenburger Romain , Boulanger Marion , Nehme Ahmad , Watrin Marguerite , Le Du Gwendoline , Guettier Sophie , Guittet Lydia , Touzé Emmanuel 
Published: May 2024

Introduction: Transient ischemic attack (TIA) is a frequent neurological emergency which management and definition have changed radically over the last 15 years. However, recent epidemiological studies of TIA are scarce. We report here on the impact of the shift from a time-based to a tissue-based definition of TIA on its incidence and risk of recurrence in a new population-based cohort with a high rate of patients investigated by MRI. Materials and methods: We prospectively included all TIAs that occurred between May 2017 and May 2021 from the Normandy Stroke Study, a population-based registry using multiple overlapping sources for exhaustive case identification in Caen la Mer area. TIAs were classified as either time-based (symptoms <24 h) or tissue-based (<24 h and no lesion on brain imaging). Attack and incidence rates were calculated, as was the 90-day ischemic stroke rate. Results: Five hundred and sixty-seven TIAs (549 single patients) were included, with 80.6% having a brain MRI. Four hundred and ten (72.3%) met the definition of tissue-based TIA. The age standardized attack (to the 2013 European population) rate was 39.5 (95% CI 35.7–43.5) and the age-standardized incidence rate (first ever cerebrovascular event) was 29.7 (95% CI 27.3–34.2). The overall recurrent stroke rate at 90 days was 2.7%, with no difference between patients with or without ischemic lesions on MRI. Conclusion: We found that the use of the tissue-based definition of TIA resulted in a 27.5% reduction in incidence as compared to the time-based definition, but had no impact on the 90-day stroke rate. The burden of TIA remains high, and is likely to increase as the population ages.
Neoantigen landscape supports feasibility of personalized cancer vaccine for follicular lymphoma
Authors: Ramirez Cody A. , Becker-Hapak Michelle , Singhal Kartik , Russler-Germain David A. , Frenkel Felix , Barnell Erica K. , McClain Ethan D. , Desai Sweta , Schappe Timothy , Onyeador Onyinyechi C. , Kudryashova Olga , Belousov Vladislav , Bagaev Alexander , Ocheredko Elena , Kiwala Susanna , Hundal Jasreet , Skidmore Zachary L. , Watkins Marcus P. , Mooney Thomas B. , Walker Jason R. , Krysiak Kilannin , Gomez Felicia , Fronick Catrina C. , Fulton Robert S. , Schreiber Robert D. , Mehta-Shah Neha , Cashen Amanda F. , Kahl Brad S. , Ataullakhanov Ravshan , Bartlett Nancy L. , Griffith Malachi , Griffith Obi L. , Fehniger Todd A. 
Published: May 2024

Abstract
Personalized cancer vaccines designed to target neoantigens represent a promising new treatment paradigm in oncology. In contrast to classical idiotype vaccines, we hypothesized that “polyvalent” vaccines could be engineered for the personalized treatment of follicular lymphoma (FL) using neoantigen discovery by combined whole-exome sequencing (WES) and RNA sequencing (RNA-seq). Fifty-eight tumor samples from 57 patients with FL underwent WES and RNA-seq. Somatic and B-cell clonotype neoantigens were predicted and filtered to identify high-quality neoantigens. B-cell clonality was determined by the alignment of B-cell receptor (BCR) CDR3 regions from RNA-seq data, grouping at the protein level, and comparison with the BCR repertoire from healthy individuals using RNA-seq data. An average of 52 somatic mutations per patient (range, 2-172) were identified, and ≥2 (median, 15) high-quality neoantigens were predicted for 56 of 58 FL samples. The predicted neoantigen peptides were composed of missense mutations (77%), indels (9%), gene fusions (3%), and BCR sequences (11%). Building off of these preclinical analyses, we initiated a pilot clinical trial using personalized neoantigen vaccination combined with PD-1 blockade in patients with relapsed or refractory FL (#NCT03121677). Synthetic long peptide vaccines targeting predicted high-quality neoantigens were successfully synthesized for and administered to all 4 patients enrolled. Initial results demonstrate feasibility, safety, and potential immunologic and clinical responses. Our study suggests that a genomics-driven personalized cancer vaccine strategy is feasible for patients with FL, and this may overcome prior challenges in the field. This trial was registered at www.ClinicalTrials.gov as #NCT03121677.
Direct mineral content prediction from drill core images via transfer learning
Authors: Boiger Romana , Churakov Sergey V. , Ballester Llagaria Ignacio , Kosakowski Georg , Wüst Raphael , Prasianakis Nikolaos I. 
Published: May 2024

AbstractDeep subsurface exploration is important for mining, oil and gas industries, as well as in the assessment of geological units for the disposal of chemical or nuclear waste, or the viability of geothermal energy systems. Typically, detailed examinations of subsurface formations or units are performed on cuttings or core materials extracted during drilling campaigns, as well as on geophysical borehole data, which provide detailed information about the petrophysical properties of the rocks. Depending on the volume of rock samples and the analytical program, the laboratory analysis and diagnostics can be very time-consuming. This study investigates the potential of utilizing machine learning, specifically convolutional neural networks (CNN), to assess the lithology and mineral content solely from analysis of drill core images, aiming to support and expedite the subsurface geological exploration. The paper outlines a comprehensive methodology, encompassing data preprocessing, machine learning methods, and transfer learning techniques. The outcome reveals a remarkable 96.7% accuracy in the classification of drill core segments into distinct formation classes. Furthermore, a CNN model was trained for the evaluation of mineral content using a learning data set from multidimensional log analysis data (silicate, total clay, carbonate). When benchmarked against laboratory XRD measurements on samples from the cores, both the advanced multidimensional log analysis model and the neural network approach developed here provide equally good performance. This work demonstrates that deep learning and particularly transfer learning can support extracting petrophysical properties, including mineral content and formation classification, from drill core images, thus offering a road map for enhancing model performance and data set quality in image-based analysis of drill cores.
Characterization of sexual maturity-associated N6-methyladenosine in boar testes
Authors: Zhang Pengfei , Zhang Fei , Sui Heming , Yang Xingyu , Ji Yiming , Zheng Shenghao , Li Wei , Cheng Kun , Wang Chonglong , Jiao Jun , Zhang Xiaodong , Cao Zubing , Zhang Yunhai 
Published: May 2024

Abstract
Background
The health and size of the testes are crucial for boar fertility. Testicular development is tightly regulated by epigenetics. N6-methyladenosine (m6A) modification is a prevalent internal modification on mRNA and plays an important role in development. The mRNA m6A methylation in boar testicular development still needs to be investigated.

Results
Using the MeRIP-seq technique, we identify and profile m6A modification in boar testes between piglets and adults. The results showed 7783 distinct m6A peaks in piglets and 6590 distinct m6A peaks in adults, with 2,471 peaks shared between the two groups. Enrichment of GO and KEGG analysis reveal dynamic m6A methylation in various biological processes and signalling pathways. Meanwhile, we conjointly analyzed differentially methylated and expressed genes in boar testes before and after sexual maturity, and reproductive related genes (TLE4, TSSK3, TSSK6, C11ORF94, PATZ1, PHLPP1 and PAQR7) were identified. Functional enrichment analysis showed that differential genes are associated with important biological functions, including regulation of growth and development, regulation of metabolic processes and protein catabolic processes.

Conclusion
The results demonstrate that m6A methylation, differential expression and the related signalling pathways are crucial for boar testicular development. These results suggest a role for m6A modification in boar testicular development and provided a resource for future studies on m6A function in boar testicular development.