bluuebunny/crossref_metadata_2025_split huggingface dataset:
“A Story We're Telling”
Authors: Luckert Erika 
Published: May 2024

Abstract
This essay suggests that our understanding of writing workshop pedagogy has been limited by a divide between composition and creative writing, and by the ways we've narrated this pedagogy in our respective fields, leaving us with little knowledge of what actually happens in writing workshops. To open new possibilities within workshop pedagogy, the author argues, we need to tell our workshop stories differently: not as method or myth, but as a complex classroom scene.
Minorities Face Delays to Pancreatic Cancer Treatment Regardless of Diagnosis Setting
Authors: Fallon John , Standring Oliver , Vithlani Nandan , Demyan Lyudmyla , Shah Manav , Gazzara Emma , Hartman Sarah , Pasha Shamsher , King Daniel A. , Herman Joseph M. , Weiss Matthew J. , DePeralta Danielle , Deutsch Gary 
Published: May 2024

Abstract
Introduction
Our analysis was designed to characterize the demographics and disparities between the diagnosis of pancreas cancer during emergency presentation (EP) and the outpatient setting (OP) and to see the impact of our institutions pancreatic multidisciplinary clinic (PMDC) on these disparities.

Methods
Institutional review board-approved retrospective review of our institutional cancer registry and PMDC databases identified patients diagnosed/treated for pancreatic ductal adenocarcinoma between 2014 and 2022. Chi-square tests were used for categorical variables, and one-way ANOVA with a Bonferroni correction was used for continuous variables. Statistical significance was set at p < 0.05.

Results
A total of 286 patients met inclusion criteria. Eighty-nine patients (31.1%) were underrepresented minorities (URM). Fifty-seven (64.0%) URMs presented during an EP versus 100 (50.8%) non-URMs (p = 0.037). Forty-one (46.1%) URMs were reviewed at PMDC versus 71 (36.0%) non-URMs (p = 0.10). No differences in clinical and pathologic stage between the cohorts (p = 0.28) were present. URMs took 22 days longer on average to receive treatment (66.5 days vs. 44.8 days, p = 0.003) in the EP cohort and 18 days longer in OP cohort (58.0 days vs. 40.5 days, p < 0.001) compared with non-URMs. Pancreatic Multidisciplinary Clinic enrollment in EP cohort eliminated the difference in time to treatment between cohorts (48.3 days vs. 37.0 days; p = 0.151).

Results
Underrepresented minorities were more likely to be diagnosed via EP and showed delayed times to treatment compared with non-URM counterparts. Our PMDC alleviated some of these observed disparities. Future studies are required to elucidate the specific factors that resulted in these findings and to identify solutions.
Like Stars: How Firms Learn at Scientific Conferences
Authors: Baruffaldi Stefano , Poege Felix 
Published: May 2024

Scientific conferences are an underexplored channel by which firms can learn from science. We provide empirical evidence that firms learn from scientific conferences in which they participate but also that this is conditional on intense participation. Using data from conference papers in computer science since the 1990s, we show that corporate investments in participation are both frequent and highly skewed, with some firms contributing to a given conference scientifically, some as sponsors, and some doing both. We use direct flights as an instrumental variable for the probability that other scientists participate in the same conference as a firm, altering the knowledge set to which the firm is exposed. We find that a firm’s use of scientists’ knowledge increases when they participate in the same conferences. Greater participation efforts, where the firm seeks the spotlight by both sponsoring the conference and contributing to its scientific discourse, foretell research collaborations and a stronger learning effect. Such learning is disproportionately concentrated among the most prominent firms and scientists rather than benefitting those without alternative interaction channels. Therefore, on average, firms learn from scientists that they encounter at conferences, but the substantial heterogeneity of the effect reflects the influence of reputation mechanisms in social interactions. This paper was accepted by Ashish Arora, entrepreneurship and innovation. Funding: S. Baruffaldi acknowledges financial support from the Swiss Science National Foundation (Reference No.: P2ELP1-161847). Supplemental Material: The online appendix and data files are available at https://doi.org/10.1287/mnsc.2022.01373 .
Post Plating Aseptic Non Union of Diaphyseal Fractures of Long Bones - A Treatment Protocol by Dual Plating
Authors: Mittal Krishna Kumar , Agarwal Apoorva , Nishant Raj 
Published: May 2024

Purpose:
Non-union is an irreversible stage in cascade of fracture healing devoid of all potentials of regeneration. Etiology of nonunion is multifactorial, categorized into mechanical, biological and infective. Implant failure is a consequence, not cause of non-union. Failed post osteosynthesis non-unions following once/multiple surgical interventions is challenging due to previous fibrous and scar tissues, osteoporosis, compromised vascularity of bone and soft tissues, dormant infection and presence of failed implant. This study aims to propose a treatment protocol for refractory non-unions of diaphyseal fractures with co-morbidities optimization.

Method:
Fourteen patients having post plating non-union in humerus (n=8), femur (n=5), tibia (n=1), subjected to dual-plating, the first plate applied on tensile surface of bone which is larger than second orthogonal plate. Osteo-periosteal decortication and cancellous bone graft carried out in every patient with atrophic non-union. Reborne bone healing score for radiological union was used to assess results. ICC (Intraclass Correlation Coefficient) was calculated.

Result:
All patients followed till union. On average non-union of humerus took 4 months while femur, tibia took 6 months to heal. All patients regained functional stable limb with painless range of motion. The ICC increased to 0.94 (95% CI 0.90 to 0.96), showing almost perfect agreement.

Conclusion:
Favorable mechanical and biological environments in absence of infection provided by dual plating, decortication and bone grafting converts non-union into osseous union. Dual plating increases strength and stiffness of construct providing stability, decortication and cancellous bone-graft re-initiates cellular and bio-chemical responses for healing.
A Clinical Study of Surgical Management of Clavicle Fracture with Titanium Elastic Nail
Authors: Sodha Rajvir Sinh , Agarwal Varun Kumar , Thimmappa Somasekharappa 
Published: May 2024

Background and Objectives:
Clavicle fractures account for 3-5% of all fractures, of them 70-80% are middle shaft fractures. Conservative management was treatment of choice in past but due to increased fracture rates and dissatisfaction of patients due to nonoperative treatment; management of these fractures has shifted to operative one. Early complications are neurovascular bundle injury, skin laceration, bleeding. Late complications include malunion leading to shoulder shortening. Newer method for clavicle fracture is intramedullary nailing using Titanium elastic nails. TEN is flexible and assume s shape of clavicle and holds the fragments in-situ by 3 points fixation principle. It also prevents the rotation, angulation and shortening of fragments.

Materials and Methods:
A study of 30 cases was conducted at Department of Orthopedics, Rohilkhand Medical College Bareilly from November 2018 to November 2019. These patients operated with titanium elastic nail (TEN) with follow up for 6 months included.

Results:
Majority of patients in our study 13 patients (43.3%) were in the age group of 25-35 years. The average age was 38.7±11.4 yrs (range from 25 to 60). 23 patients were successfully treated with closed reduction and nail insertion while 7 patients had to undergo mini-open (minimal incision) for fracture reduction. Mean operative time was 23.5 minutes (15-38.5 minutes). Out of 30 patients 26(86.67%) had excellent outcome, 2(6.67%) had fair outcome, 1(3.34%) had good outcome and 1(3.34%) had poor outcome.

Conclusion:
The study shows that fixation of clavicular fractures with Titanium Elastic Nailing System (TENS) is easy to do procedure which gives faster pain relief, speedy functional recovery. Moreover, the Cosmetic problems due to post- operative scar and other postoperative complications are lower.
Management of Recurrent Anterior Shoulder Dislocation by Modified Boytchev Procedure- Our Experience
Authors: Kumar Sanjay , Khan Nadeem Ashraf , Tandan Bhoopendra Singh 
Published: May 2024

Background:
Recurrent anterior shoulder dislocation is not uncommon. Although the etiology for recurrent anterior shoulder dislocation is not very clear, there are 3 lesions usually responsible for its occurrence: Bankart lesion, Hill-Sachs lesion and laxity of subscapularis muscle. Several operations have been described for the treatment of recurrent anterior dislocation of shoulder but only a few of them have good result in terms of recurrence and loss of shoulder movement in follow-up period. Modified Boytchev procedure is an effective, technically simple procedure for the management of recurrent anterior dislocation of shoulder.

Methods:
Ten patients with recurrent anterior dislocation of the shoulder were treated from September 2017 to August 2019 by the modified Boytchev procedure. The age of the patients varied from 20 to 38 years (average 25.6 years). Outcome was evaluated using the Burkhead and Rockwood criteria, a score of 90 to 100 was considered excellent, 70 to 89 good, 40 to 69 fair and ?39 was considered poor.

Results:
The mean follow-up period was 15.4 (SD=3.2; range=6-29) months. Outcome was excellent in 7 patients, good in 2, and fair in 1. None had poor outcome. The shoulders were stable with increased ROM in all directions. Mean external rotation deficit at 0o and 90o of improved from 18o to 7o and 21o to 10o respectively (student's paired t-test).

Conclusions:
This is an effective, technically simple procedure with minimum restriction of movements around the shoulder joint and does not require expert skills.
The experiences of people living with obesity and chronic pain: A Qualitative Evidence Synthesis (QES) protocol
Authors: Hinwood Natasha S. , Casey Maire-Brid , Doody Catherine , Blake Catherine , Fullen Brona M. , O’Donoghue Gráinne , Dunlevy Colin G. , Birney Susie , Fildes Fionnuala , Smart Keith M. 
Published: May 2024

Introduction
There is a substantial and progressive association between chronic pain (CP) and living with overweight or obesity. The relationship between obesity and CP is intricate and complex, with obesity being associated with increased pain-related disability, pain intensity, reduction in physical functioning and poorer psychological well-being. A Qualitative Evidence Synthesis (QES) provides an opportunity to better understand and reveal key areas within the patient experience of these complex interactions to inform best practice and future intervention design.

Aims
The aim of this QES is to methodically and systematically review and synthesise the qualitative literature reporting on the personal experiences of people who are both living with obesity (PwO) and chronic pain.

Methods
The phenomenon of interest of this QES is the lived experiences of PwO and CP. The following research question was developed using a modified Population, Intervention, Comparison, Outcome and Study type (PICOS) framework: “What are the lived experiences of people living with obesity and chronic pain?”. One review author will conduct a systematic search based on keywords and Medical Subject Headings (MeSH) terms for finding relevant articles in five peer-review databases, from inception to the date of searching. Two review authors will independently apply inclusion and exclusion criteria and screen articles in a two-stage process. The methodological quality of included studies will be assessed using the Critical Appraisal Skills Programme (CASP) tool and data will be extracted using a customised template. We will undertake a thematic synthesis of qualitative data from included studies and report our findings narratively. Confidence in the findings will be assessed based on the Grading of Recommendations Assessment, Development and Evaluation Confidence in Evidence from Reviews of Qualitative Research (GRADE-CER-Qual) approach.

Findings and dissemination
This study will follow the Preferred Reporting Items for Systematic Review and Meta-Analysis Protocols (PRISMA) and Enhancing Transparency in Reporting the Synthesis of Qualitative Research (ENTREQ) guidelines. It is anticipated that the findings of the review will facilitate a deep and broad understanding of the complex interactions between CP and obesity and will help inform best practice and future intervention design. Findings will be disseminated through journals that undergo peer review, presentations at conferences, engagement with public and patient advocacy groups, and social media.

Ethics and dissemination
Ethical approval is not required to conduct this review.

Trail registration
PROSPERO registration number: CRD42023361391.
Vitamin D supplementation for prevention of acute respiratory infections in older adults: A systematic review and meta-analysis
Authors: Jia Hao , Sheng Feng , Yan Yulan , Liu Xiaozhi , Zeng Baoqi 
Published: May 2024

Background
Acute respiratory infections (ARIs) have a substantial impact on morbidity, healthcare utilization, and functional decline among older adults. Therefore, we systematically reviewed evidence from randomized controlled trials (RCTs) to evaluate the efficacy and safety of vitamin D supplementation in preventing ARIs in older adults.

Methods
PubMed, Embase, the Cochrane Library, and ClinicalTrials.gov were searched until 1 February 2024. RCTs evaluating the use of vitamin D supplements to protect older adults from ARIs were included. Two reviewers independently screened papers, extracted the data and assessed the risk of bias. Data were summarised as relative risks (RRs) or odds ratios (ORs) with corresponding 95% confidence intervals (CIs). Random effects meta-analyses were used to synthesise the results. GRADE was used to evaluate the quality of evidence. All the analysis were performed with Stata version 17.

Results
Twelve trials (41552 participants) were included in the meta-analysis. It showed that vitamin D supplementation probably does not reduce the incidence of ARIs (RR, 0.99; 95% CI, 0.97–1.02, I2 = 0%; moderate certainty). No significant effect of vitamin D supplementation on the risk of ARI was observed for any of the subgroups defined by baseline 25(OH)D concentration, control treatments, dose frequency, study duration, and participants’ condition. However, there was a possibility, although not statistically significant, that vitamin D may reduce the risk of ARI in patients with a baseline 25(OH)D concentration <50 nmol/L (OR, 0.90; 95% CI, 0.79–1.04, I2 = 14.7%). Additionally, vitamin D supplements might result in little to no difference in death due to any cause, any adverse event, hypercalcinemia, and kidney stones.

Conclusions
Vitamin D supplementation among older adults probably results in little to no difference in the incidence of ARIs. However, further evidence is needed, particularly for individuals with vitamin D deficiency and populations residing in low and middle income countries.

Trial registration
This study was registered on PROSPERO (CRD42023451265).
Genome-wide analysis of long noncoding RNAs as cis-acting regulators of transcription factor-encoding genes in IgA nephropathy
Authors: Zhai Yaling , Tian Huijuan , Zhang Wenhui , Sun Shuaigang , Zhao Zhanzheng 
Published: May 2024

Background
IgA nephropathy (IgAN) is the most common form of primary glomerulonephritis in the world, but the disease pathogenesis noncoding is yet to be elucidated. Previous studies have revealed regulatory functions for long noncoding RNA (lncRNA) in various diseases; however, the roles of lncRNA in IgAN and regulation of transcription factors (TFs) have been scarcely investigated.

Methods
Renal tissue samples (n = 5) from patients with IgAN and control samples (n = 4) were collected and RNA sequencing (RNA-seq) was performed. Four software programs were employed for lncRNA prediction. GO (Gene Ontology)/KEGG (Kyoto Encyclopedia of Genes and Genomes) were employed for analysis of the identified differentially expressed genes (DEGs). A regulatory network model of DE lncRNA-TF-DEG was developed, and the levels of expression of key lncRNAs, TFs, and corresponding target genes were assessed using qRT-PCR and immunofluorescence.

Results
The current study identified 674 upregulated and 1,011 downregulated DE mRNAs and 260 upregulated and 232 downregulated DE lncRNAs in IgAN samples compared with control samples. The upregulated DE mRNAs showed enrichment in cell adhesion and collagen glial fiber organization pathways. The DE lncRNAs-DE mRNAs showing co-expression are associated with transmembrane transport. A novel regulatory network model of lncRNA-TF-DEG has been developed. This study identified seven TFs that are cis-regulated by 6 DE lncRNAs, and show co-expression with 132 DEGs (correlation coefficient ≥ 0.8, P ≤ 0.01), generating 158 pairs that showed co-expression. The lncRNAs NQO1-DT and RP5-1057120.6 were found to be highly expressed in IgAN samples. The TFs vitamin D Receptor (VDR) and NFAT5, along with their target genes were also aberrantly expressed.

Conclusion
Key lncRNAs and TFs centrally associated with IgAN have been identified in this study. A regulatory network model of lncRNA-TF-mRNA was constructed. Further studies on the genes identified herewith could provide insight into the pathogenesis of IgAN.
Economic evaluation of trastuzumab in HER2-positive early breast cancer in Indonesia: A cost-effectiveness analysis
Authors: Khoirunnisa Sudewi Mukaromah , Suryanegara Fithria Dyah Ayu , Setiawan Didik , Postma Maarten Jacobus , de Jong Lisa Aniek 
Published: May 2024

Background
Trastuzumab has significantly enhanced the survival and prognosis of individuals diagnosed with human epidermal growth factor receptor 2 (HER2)-positive early breast cancer. Considering its relatively high costs, we aimed to examine the cost-effectiveness of trastuzumab plus chemotherapy compared with chemotherapy alone in HER2-positive early breast cancer from an Indonesian healthcare payer’s perspective.

Methods
A Markov model was developed to project the lifetime health benefits and costs associated with trastuzumab treatment for a cohort of women with HER2-positive early breast cancer. Efficacy data and baseline characteristics in the base-case analysis were primarily derived from the 11-year results of the HERA trial. Costs were based on verified reimbursement data from Indonesia’s Health and Social Security Agency (BPJS Kesehatan) of the year 2020. A scenario analysis was conducted with efficacy data based on the joint analysis from the NSABP B-31 and NCCTG N9831 trials, allowing for subgroup analysis by age at diagnosis. Univariate and probabilistic sensitivity analyses were conducted to assess the influence of parameter uncertainty.

Results
In the base-case analysis, the results indicated that the lifetime costs for trastuzumab plus chemotherapy and chemotherapy alone were US$33,744 and US$22,720, respectively, resulting in substantial incremental savings of US$11,024 per patient for the former. Trastuzumab plus chemotherapy also led to higher total quality-adjusted life years (QALYs) and life years gained (LYG), resulting in incremental cost-effectiveness ratios (ICERs) of US$6,842 per QALY and US$5,510 per LYG. In scenario analysis, the subgroup with an age at diagnosis <40 years old reflected the most cost-effective subgroup. Both the base-case and scenario analyses demonstrated cost-effectiveness with a willingness-to-pay threshold of three-times Gross Domestic Product (GDP). Sensitivity analyses confirmed the robustness of the findings and conclusions.

Conclusion
In Indonesia, trastuzumab plus chemotherapy can be considered cost-effective compared to chemotherapy alone at a willingness-to-pay threshold of three times GDP, and it is likely most cost-effective in women <40 years of age.
Ethyl acetate production by Fischer esterification: use of excess of acetic acid and complete separation sequence
Authors: Sanap Pooja P. , Katariya Amit M. , Mahajan Yogesh S. 
Published: May 2024

Abstract
In this work, production of ethyl acetate (EtAc) using Fischer esterification between acetic acid (AcOH) and ethyl alcohol (EtOH) is presented. Batch kinetics was developed with EtOH as the limiting reactant to avoid the problems associated with unreacted ethanol in the final product. Regression was performed to estimate the parameters of the Langmuir Hinshelwood type kinetic equation. Reaction mass obtained during kinetics was subjected to separation and purification. Molecular sieves (MS) were used to remove water. Distillation (simple and extractive distillation – with entrainer, dimethyl sulfoxide, DMSO) was used to obtain almost pure AcOH, EtOH, EtAc and DMSO. Future work in reactive separation environment is indicated. Use of EtOH as the limiting reactant, use of MS for water removal and complete separation sequence are important features of this work.
Thermodiffusion, diffusion and Soret coefficients of binary polymeric mixtures in toluene and cyclohexane
Authors: Sanjuan Antton , Sommermann Daniel , Köhler Werner , Shevtsova Valentina , Bou-Ali M. Mounir 
Published: May 2024

Abstract
We present the results of experimental study on measuring the thermodiffusion, molecular diffusion and Soret coefficients of polystyrene (4,880 g/mol) in the pure solvents toluene and cyclohexane at 298 K and atmospheric pressure. The experiments have been carried out for a wide range of concentrations, starting from the diluted state with 2 % polystyrene mass fraction (proposed in the DCMIX4 project) up to the semidilute regime of 20 % polystyrene mass fraction. In addition, we present a complete characterisation of the thermophysical properties of the analysed mixtures. Thermodiffusion, molecular diffusion and Soret coefficients of binary polymeric samples have been measured by combining the traditional thermogravitational column technique, the thermogravitational microcolumn and the optical beam deflection method. In toluene, the obtained experimental results are consistent with literature, showing that the magnitude of the mass transport thermoproperties decrease significantly with increasing polystyrene concentration, which is a first indication of an approaching glass transition in the concentrated regime. The results for thermodiffusion and molecular diffusion coefficients in cyclohexane as a function of concentration exhibit a similar trend. Nevertheless, the Soret coefficient seems to show an opposite tendency for the two solvents, increasing in magnitude for cyclohexane, at least up to the analysed polystyrene concentration.