bluuebunny/crossref_metadata_2025_split huggingface dataset:
Competitive and Selective Csp3Br versus Csp2Br Bond Activation in Palladium‐Catalysed Suzuki Cross‐Coupling: An Experimental and Theoretical Study of the Role of Phosphine Ligands
Authors: Mollar Cristian , Besora Maria , Maseras Feliu , Asensio Gregorio , Medio‐Simón Mercedes 
Published: October 2010

AbstractPhosphine ligands have been demonstrated to have an effect on reactivity and selectivity in the competitive intramolecular palladium‐catalysed Suzuki–Miyaura coupling of dibromo sulfoxide 1 a possessing two different hybridised electrophilic carbons. It was found that the bromine bond to the sp3‐hybridised carbon is selectively replaced in the presence of unhindered phosphines such as PPh3 or xantphos. The use of hindered phosphine ligands such as P(o‐tol)3 and P(1‐naphthyl)3 reversed the selectivity, conducting the cross‐coupling at the Csp2‐Br. Identical trends were observed in external competition experiments carried out with bromomethyl sulfoxide and different substituted bromoarenes. DFT and DFT/MM calculations showed that the selectivity observed is mainly due to the different facility of the ligands to dissociate. Bisphosphine catalysts favour coupling at the sp3 carbon, whereas monophosphine catalysts prefer the sp2 carbon.
Oxidative Spirocyclization of Phenolic Sulfonamides: Scope and Applications
Authors: Liang Huan , Ciufolini Marco A. 
Published: October 2010

AbstractA full account of the oxidative dearomatization of para‐ and ortho‐phenolic sulfonamides is provided together with an overview of the chemistry of the products and their elaboration to building blocks for spirocyclic alkaloids. A concise total synthesis of putative lepadiformine complements the discussion.
Titanosilicate Beads with Hierarchical Porosity: Synthesis and Application as Epoxidation Catalysts
Authors: Lin Kaifeng , Lebedev Oleg I. , Van Tendeloo Gustaaf , Jacobs Pierre A. , Pescarmona Paolo P. 
Published: October 2010

AbstractPorous titanosilicate beads with a diameter of 0.5–1.5 mm (TiSil‐HPB‐60) were synthesized from a preformed titanosilicate solution with a porous anion‐exchange resin as template. The bead format of this material enables its straightforward separation from the reaction mixture in its application as a liquid‐phase heterogeneous catalyst. The material displays hierarchical porosity (micro/mesopores) and incipient TS‐1 structure building units. The titanium species are predominantly located in tetrahedral framework positions. TiSil‐HPB‐60 is a highly active catalyst for the epoxidation of cyclohexene with t‐butyl hydroperoxide (TBHP) and aqueous H2O2. With both oxidants, TiSil‐HPB‐60 gave higher epoxide yields than Ti‐MCM‐41 and TS‐1. The improved catalytic performance of TiSil‐HPB‐60 is mainly ascribed to the large mesopores favoring the diffusion of reagents and products to and from the titanium active sites. The epoxide yield and selectivity could be further improved by silylation of the titanosilicate beads. Importantly, TiSil‐HPB‐60 is a stable catalyst immune to titanium leaching, and can be easily recovered and reused in successive catalytic cycles without significant loss of activity. Moreover, TiSil‐HPB‐60 is active and selective in the epoxidation of a wide range of bulky alkenes.
ChemInform Abstract: Ternary Silicides Sc3TSi3 (T: Ru, Rh, Ir, Pt) — Structure, Chemical Bonding, and Solid State NMR.
Authors: Harmening Thomas , Mohr Daniel , Eckert Hellmut , Al Alam Adel , Matar Samir F. , Poettgen Rainer 
Published: October 2010

AbstractThe new title compounds are prepared by arc‐melting of the elements and characterized by powder and single crystal XRD, 45Sc MAS NMR spectroscopy, and DFT electronic structure calculations for the Ru compound.
ChemInform Abstract: High‐Pressure High‐Temperature Synthesis, Magnetic Properties and X‐Ray Absorption Spectroscopy of Phases RE3Sn7 and hp‐RESn3‐x (RE: Tb, Ho, Er).
Authors: Meier Katrin , Vasylechko Leonid , Cardoso‐Gil Raul , Burkhardt Ulrich , Schnelle Walter , Schmidt Marcus , Grin Yuri , Schwarz Ulrich 
Published: October 2010

AbstractThe high‐temperature, high‐pressure syntheses of hp‐LnSn3‐x (Ln: Tb, Ho, Er) are reinvestigated.
ChemInform Abstract: Intermetallic and Metal‐Rich Phases in the System Li—Ba—In—N.
Authors: Smetana Volodymyr , Vajenine Grigori V. , Kienle Lorenz , Duppel Viola , Simon Arndt 
Published: October 2010

AbstractTwo new subnitrides in the title system and three Li—In—Ba intermetallic phases are characterized by single crystal XRD and TEM.
ChemInform Abstract: Synthesis of Li2PtH6 Using High Pressure: Completion of the Homologous Series A2PtH6 (A: Alkali Metal).
Authors: Puhakainen Kati , Stoyanov Emil , Evans Michael J. , Leinenweber Kurt , Haeussermann Ulrich 
Published: October 2010

AbstractThe title compound is synthesized from mixtures of LiH and Pt in the presence of BH3NH3 (multi‐anvil device, <8 GPa, 450—500 °C, 60 min) and characterized by powder XRD and IR spectroscopy.
ChemInform Abstract: Enantioselective Desymmetrization of meso‐N‐(Heteroarenesulfonyl)aziridines with TMSN3 Catalyzed by Chiral Lewis Acids.
Authors: Nakamura Shuichi , Hayashi Masashi , Kamada Yasutoshi , Sasaki Ryosuke , Hiramatsu Yuichi , Shibata Norio , Toru Takeshi 
Published: October 2010

AbstractOptimized reaction conditions are developed to give functionalized azides with moderate to high enantioselectivity.
ChemInform Abstract: Asymmetric Catalytic Strecker Reaction of N‐Phosphonyl Imines with Et2AlCN Using Amino Alcohols and BINOLs as Catalysts.
Authors: Kaur Parminder , Pindi Suresh , Wever Walter , Rajale Trideep , Li Guigen 
Published: October 2010

AbstractBoth free amino alcohols and BINOL derivatives are shown to be excellent catalysts for achieving good yields and enantioselectivities in the title reaction.
ChemInform Abstract: Pyrrole‐2‐carbohydrazides as Ligands for Cu‐Catalyzed Amination of Aryl Halides with Amines in Pure Water.
Authors: Xie Jianwei , Zhu Xinhai , Huang Manna , Meng Fei , Chen Weiwei , Wan Yiqian 
Published: October 2010

AbstractAryl bromides and iodides are aminated by primary and secondary amines either under microwave irradiation or conventional heating in the same short reaction time.
ChemInform Abstract: Synthesis, Characterization and Biological Evaluation of Some Heterocyclic Compounds Containing Ethoxyphthalimide Moiety via Key Intermediate 6‐Chloro 1,3‐Benzothiazole 2‐Amine.
Authors: Sain Devendra Kr , Thadhaney Bhawana , Joshi Ajit , Hussain Nasir , Talesara Ganpat L. 
Published: October 2010

AbstractAll compounds (V) and (VIII) exhibit good to moderate activity against a pannel of bacteria and fungi.
ChemInform Abstract: A New Microwave‐Assisted Organocatalytic Solvent‐Free Synthesis of Optically Enriched Michael Adducts.
Authors: Procopio Antonio , De Nino Antonio , Nardi Monica , Oliverio Manuela , Paonessa Rossella , Pasceri Raffaele 
Published: October 2010

AbstractGood enantioselectivities are achieved only in case of adducts (IIIa,b).
ChemInform Abstract: Enantioselective Synthesis of Bicyclo[3.2.1]octan‐8‐ones Using a Tandem Michael—Henry Reaction.
Authors: Ding Derong , Zhao Cong‐Gui , Guo Qunsheng , Arman Hadi 
Published: October 2010

AbstractThe reaction between cyclohexane‐1,2‐diones and nitroalkenes is catalyzed by the epiquinine‐derived thiourea catalyst and proceeds with high enantio‐ and diastereoselectivities.
ChemInform Abstract: Pauson—Khand Reaction of Allenic Hydrocarbons: Synthesis of 4‐Alkylidenecyclopentenones.
Authors: Antras Frederic , Laurent Stephane , Ahmar Mohammed , Chermette Henry , Cazes Bernard 
Published: October 2010

AbstractA comprehensive study of the reaction of in situ generated dicobalthexacarbonyl complexes of disubstituted alkynes, terminal alkynes, or acetylene with a variety of mono‐ and disubstituted allenes is presented yielding mainly the title cyclopentenones.
ChemInform Abstract: MgCl2‐Accelerated Addition of Functionalized Organozinc Reagents to Aldehydes, Ketones, and Carbon Dioxide.
Authors: Metzger Albrecht , Bernhardt Sebastian , Manolikakes Georg , Knochel Paul 
Published: October 2010

AbstractThe reactivity of functionalized arylzinc and benzylzinc reagents is significantly improved in the presence of MgCl2.
ChemInform Abstract: Highly (E)‐Selective BF3·Et2O‐Promoted Allylboration of Chiral Nonracemic α‐Substituted Allylboronates and Analysis of the Origin of Stereocontrol.
Authors: Chen Ming , Roush William R. 
Published: October 2010

Abstract(E)‐δ‐Methyl‐substituted homoallylic alcohols (III) are prepared in high yields and excellent enantioselectivities from α‐methyl‐allylboronate, derived from pinanediol.
ChemInform Abstract: Palladium‐Catalyzed Unsymmetrical Aryl Couplings in Sequence Leading to o‐Teraryls: Dramatic Olefin Effect on Selectivity.
Authors: Motti Elena , Della Ca' Nicola , Deledda Sara , Fava Emanuela , Panciroli Francesca , Catellani Marta 
Published: October 2010

AbstractThe palladium/norbornene‐catalyzed sequential one‐pot‐reaction of aryl iodides, aryl bromides and aryl boronic acids affords o‐teraryls in high yields.
ChemInform Abstract: Organocatalytic Enantioselective Friedel—Crafts Alkylation of Sesamol with Nitro Olefins.
Authors: Zhang Hui , Liao Yu‐Hua , Yuan Wei‐Chen , Zhang Xiao‐Mei 
Published: October 2010

AbstractThe bifunctional chiral thiourea—tertiary amine THU derived from cinchonine catalyzes the alkylation of sesamol and 2‐substituted derivatives with aromatic nitro olefins with up to 90% enantioselectivity.
ChemInform Abstract: Ligand‐Free Palladium Catalytic System Supported by CNT and Its Application to the Mizoroki—Heck Reactions.
Authors: Jo Youngshin , Kim Ja Young , Oh Il‐Kwon , Choi Hyun Chul , Lee Sunwoo 
Published: October 2010

AbstractAryl‐substituted alkenes (III) are synthesized by Mizoroki—Heck coupling using carbon nanotubes supported Pd(dba)2 as catalyst.
ChemInform Abstract: Rhenium‐Catalyzed Synthesis of Indenones by Novel Dehydrative Trimerization of Aryl Aldehydes via C—H Bond Activation.
Authors: Kuninobu Yoichiro , Matsuki Takashi , Takai Kazuhiko 
Published: October 2010

AbstractAryl aldehydes are easily converted to the indenone derivatives in high yields, tolerating many functional groups [cf.
ChemInform Abstract: High Stereoselectivity in the Diels—Alder Reaction of Substituted Anthracenes: Reactions of 1‐Succinimidoanthracene and 1‐Phthalimidoanthracene with Maleic Anhydride.
Authors: Singh M. Dhaneshwar , Ningombam Anjana 
Published: October 2010

AbstractThe title reaction is influenced by steric factors yielding predominantly the anti adducts (III).
ChemInform Abstract: Preparation and Properties in vitro and in vivo of Antitubercular Pyrroles.
Authors: Hearn Michael J. , Chen Michaeline F. , Terrot Marianne S. , Webster Eleanor R. , Cynamon Michael H. 
Published: October 2010

AbstractThe title compounds (III) are conveniently prepared by Paal—Knorr reaction of hydrazides (II) with hexane‐2,5‐dione without an acid catalyst.
ChemInform Abstract: A Facile, Protic Ionic Liquid Route to N‐Substituted 5‐Hydroxy‐4‐methyl‐3‐oxoisoindoline‐1‐carboxamides (II) and N‐Substituted 3‐Oxoisoindoline‐4‐carboxylic Acids (VII).
Authors: Gordon Christopher P. , Byrne Nolene , McCluskey Adam 
Published: October 2010

AbstractA highly efficient, atom‐economic, and mild protocol for the synthesis of highly substituted members of the title series and is described.
ChemInform Abstract: Synthesis of Reaction‐Ready 6,6′‐Biindole and 6,6′‐Biisatin via Palladium(II)‐Catalyzed Intramolecular C—H Functionalization.
Authors: Gamble Allan B. , Keller Paul A. 
Published: October 2010

AbstractThe synthesis of two novel symmetrical 6,6′‐biheterocycles (VI) and (IX) from a common bisaniline intermediate (III) is reported.
ChemInform Abstract: Palladium‐Catalyzed Direct Oxidative Heck—Cassar—Sonogashira Type Alkynylation of Indoles with Alkynes under Oxygen.
Authors: Yang Luo , Zhao Liang , Li Chao‐Jun 
Published: October 2010

AbstractUnlike previous methods, the title reaction does not need the pregeneration of indolyl or alkynyl halide.
ChemInform Abstract: Application of 1,3‐Azomethine Ylides Derived from α‐Dicarbonyl Compounds and L‐Proline to the Synthesis of Pyrrolizidines.
Authors: Felluga Fulvia , Forzato Cristina , Nitti Patrizia , Pitacco Giuliana , Valentin Ennio , Zangrando Ennio 
Published: October 2010

AbstractThe one‐pot three‐component reaction between diacetyl compounds (I), β‐nitrostyrene (II), and L‐proline (III) in isopropanol at room temperature affords the regioisomeric cycloadducts (IV) and (V).
ChemInform Abstract: Organocatalyzed Regio‐ and Stereoselective Diamination of Functionalized Alkenes.
Authors: Wu Hui , Ji Xiaoyun , Sun Hao , An Guanghui , Han Jianlin , Li Guigen , Pan Yi 
Published: October 2010

AbstractThe reaction can be equally catalyzed by triphenylphosphine, diphenyl sulfane, tri‐ and dibutylamine or 2‐aminoethanol.
ChemInform Abstract: Zeo‐Click Synthesis: CuI‐Zeolite‐Catalyzed One‐Pot Two‐Step Synthesis of Triazoles from Halides and Related Compounds.
Authors: Beneteau Valerie , Olmos Andrea , Boningari Thirupathi , Sommer Jean , Pale Patrick 
Published: October 2010

AbstractThe reaction works best with organic bromides: 1,3‐dipolar cycloaddition of the resulting alkyl‐ and aryl azides with terminal alkynes affords disubstituted 1,2,3‐triazoles regioselectively.
ChemInform Abstract: Stereoselective Synthesis of β‐Amino Ketones Possessing β‐[(2H‐Pyran‐2‐one)‐3‐yl]‐β‐chlorovinyl Moiety via Three‐Component Direct Mannich Reaction, Catalyzed with ZrOCl2·8H2O.
Authors: Shahrisa Aziz , Zirak Maryam 
Published: October 2010

AbstractThe new β‐chloroacrolein with a pyranone moiety (III) is subjected to a three‐component Mannich‐type reaction with anilines (IV), cyclic ketones (V), and acyclic ketones in the presence of a zirconium catalyst.
ChemInform Abstract: Facile Synthesis of 2,6‐Diaryl‐4‐secondary Aminonicotinonitriles and Highly Substituted Unsymmetrical 2,2′‐Bipyridines.
Authors: Bhosale Sidhanath V. , Patil Umesh D. , Kalyankar Mohan B. , Nalage Santosh V. , Patil Vijay S. , Desale Kamlesh R. 
Published: October 2010

AbstractThe ring transformation of 2H‐pyran‐2‐ones by N‐aryl amidines is strongly influenced by the amidine substituents and leads to title compounds of type (III).
ChemInform Abstract: The Baylis—Hillman Adducts as Valuable Source for One‐Pot Multi‐Step Synthesis: A Facile Synthesis of Substituted Piperidin‐2‐ones.
Authors: Basavaiah Deevi , Reddy Raju Jannapu , Lenin Dandamudi V. 
Published: October 2010

AbstractThe method involves a Johnson—Claisen rearrangement and reduction of an α,β‐unsaturated nitrile moiety.
ChemInform Abstract: Efficient Synthesis of Phenanthridines Using Hendrickson Reagent Initiated Cascade Reaction under Mild Conditions.
Authors: Xi Jie , Dong Qing‐Li , Liu Guan‐Sai , Wang Shaozhong , Chen Lin , Yao Zhu‐Jun 
Published: October 2010

AbstractTreatment of 2‐aminobiphenyl amides with Hendrickson reagent results in formation of a highly reactive imido‐carbonium intermediate.
ChemInform Abstract: Synthesis of Imidazo[1,2‐c]quinazolin‐5(6H)‐ones and Benzimidazo[1,2‐c]quinazolin‐6(5H)‐ones with the Aid of Low‐Valent Titanium Reagent.
Authors: Zhao Xuan , Shi Da‐Qing 
Published: October 2010

AbstractA short and facile synthesis of the title compounds (III) and (V) via a novel reductive cyclization of corresponding 2‐(o‐nitrophenyl)imidazoles promoted by a low‐valent titanium reagent is developed.
ChemInform Abstract: One‐Pot Approach to the Synthesis of Novel 12H‐Chromeno[2′,3′:4,5]imidazo[1,2‐a]pyridines in Aqueous Media.
Authors: Proenca M. Fernanda , Costa Marta 
Published: October 2010

AbstractUnprecedented cascade condensation/cyclization reaction of salicyl aldehydes and substituted 1‐(cyanomethyl) pyridinium chlorides affords the desired tetracyclic products.
ChemInform Abstract: Microwave‐Enhancend Rhodium‐Catalyzed [2 + 2 + 2] Cycloaddition Reactions to Afford Highly Functionalized Pyridines and Bipyridines.
Authors: Garcia Lidia , Pla‐Quintana Anna , Roglans Anna , Parella Teodor 
Published: October 2010

AbstractA series of cyanodiynes is subjected to a Rh(I)‐catalyzed [2+2+2] cycloaddition reaction to afford efficiently tricyclic‐fused pyridines and bipyridines.
ChemInform Abstract: Eco‐Friendly, Solvent‐Free Novel One‐Pot, Three‐Component Synthesis of Quinazolinones at Ambient Temperature Catalyzed by Silica Gel Supported Phosphomolybdic Acid.
Authors: Sabitha Gowravaram , Reddy N. Mallikarjuna , Prasad M. Nagendra , Raja G. S. K. , Yadav J. S. 
Published: October 2010

AbstractThe title catalyst can be recovered and reused.
ChemInform Abstract: Concise Access to N9‐Mono‐, N2‐Mono‐ and N2,N9‐Disubstituted Guanines via Efficient Mitsunobu Reactions.
Authors: Fletcher Steven , Shahani Vijay M. , Lough Alan J. , Gunning Patrick T. 
Published: October 2010

AbstractProtection/activation strategy is applied to the preparation of the target compounds with high regioselectivity.
ChemInform Abstract: Daphnane‐Type Diterpenoids from the Flower Buds of Daphne genkwa.
Authors: Li Ling‐Zhi , Gao Pin‐Yi , Peng Ying , Wang Li‐Hui , Yang Jing‐Yu , Wu Chun‐Fu , Zhang Yan , Song Shao‐Jiang 
Published: October 2010

AbstractThree novel compounds, genkwanines M (I), N (II) and optically active genkwanine O (III) are isolated.
ChemInform Abstract: Cytotoxic C35 Terpenoid Cryptotrione from the Bark of Cryptomeria japonica.
Authors: Chen Cheng‐Chi , Wu Jyh‐Horng , Yang Ning‐Sun , Chang Jang‐Yang , Kuo Ching‐Chuan , Wang Sheng‐Yang , Kuo Yueh‐Hsiung 
Published: October 2010

Abstract(I) Exhibits anticancer activity with an IC50 value 6.44.+‐.2.23 μM.
ChemInform Abstract: Abietane Diterpenoids and a Lignan from Pinus yunnanensis.
Authors: Feng Tao , Cai Xiang‐Hai , Tan Qin‐Gang , Luo Xiao‐Dong 
Published: October 2010

AbstractTwo new abietane diterpene acids, pinyunins A (I) and B (II), and the lignan (III) are isolated along with eight known diterpenoids.
Recovery of Phosphate Sludge as Concrete Supplementary Material
Authors: Doğan Özgür , Karpuzcu Mehmet 
Published: October 2010

AbstractThe automotive industry plays a major role in the worldwide economy and represents an opportunity to increase the performance of the Turkish economy. Phosphating units in the automotive manufacturing plants generate phosphate sludge as waste, which is classified as hazardous waste in the European Waste Catalogue. Phosphate sludge must be disposed of in licensed disposal plants according to the current environmental regulations. Solidification/stabilization (S/S) is a widely used treatment technology for the disposal of hazardous wastes. Portland cement is used for the solidification and stabilization processes to immobilize Ni and Zn in the phosphate sludge as well as to create construction material to be used as cobble stone for pavement. Examination of products obtained by S/S processes is performed for two points: to determine the quality and to assess the environmental impacts. The phosphate sludge samples are subjected to chemical characterization and a size distribution analysis leaching test. Concrete for cobble stone was produced by the S/S process with the addition of phosphate sludge to replace sand. Tests for the quality of the product were carried out to determine compressive strength, permeability, and elasticity. At the end of the leaching test, elution concentrations of Zn and Ni while using water with pH values of 4.0, 5.4, and 9.0 were determined to be under the limit of inert material properties. Use of phosphate sludge should be considered as a sand replacement in the proportion of 1% of phosphate sludge to cement in concrete production, such as for cobble stone for pavement, without any adverse environmental impacts.
Ordinal scale based description of colour rendering
Authors: Bodrogi Peter , Brückner Stefan , Khanh Tran Quoc 
Published: October 2010

AbstractPerceived colour differences of 17 test colour samples (uniform standalone patches) were evaluated visually between a test and a reference light source on three visual scales. Two graphical rating scales (a greyscale‐anchored colour difference scale and a similarity judgement scale) and a five‐step ordinal rating scale (excellent, good, acceptable, not acceptable or very bad colour rendering) were used. The experimental setup included tungsten halogen, gas discharge, fluorescent, and white LED light sources at two correlated colour temperatures, 2700 and 4500 K. There was an inverse relationship between similarity judgement and visual colour difference results. Each category of the five‐step ordinal rating scale had a characteristic mean visual colour difference value. Visual colour differences correlated best with the recently developed CIECAM02‐UCS colour difference metric. Latter metric was used to predict the observers' ratings of visual colour differences on the above five‐step ordinal rating scale. From the predicted ratings of 17 test‐colour samples under the test light source, a new ordinal rating scale based colour rendering index (RCRI) was defined and compared with previous colour rendering indices. RCRI correlated well with both the mean visual colour differences and the mean similarity judgements. Despite the significant interobserver differences of the visual assessment of colour differences, the RCRI method showed an overall performance of 73% in terms of good predictions of the rating categories. Validation experiments with complex still life (tabletop) stimuli are currently underway. © 2010 Wiley Periodicals, Inc. Col Res Appl, 2010
An adaptive receiver of joint data and channel estimation for meteor burst communications
Authors: Cai Jueping , Li Zan , Chen Xiaojun , Hao Benjian 
Published: October 2010

AbstractIn view of the characteristics of the meteor burst channel, the variable rate data transmission should be adopted to improve the system average throughput, which results in channel tracing and equalization problems at the receiver. Although the joint data and channel estimation of maximum likelihood sequence detection performing the principle of per‐survivor processing (PSP) is considered as an optimal detection scheme, its great computational complexity is a major problem and can hardly agree with the decreasing of the meteor channel. Based on the estimation of the system parameters, an adaptive state reduction of the PSP (ASRP) algorithm with only a few states in the trellis diagram is employed, while these states are chosen by the time‐varying threshold according to the exponential decay of meteor channels. It is shown that, ASRP can make a good tradeoff between the performance and the computational complexity, and provides reliable data transmission for adaptive modulation and coding of the meteor burst communication system. Computer simulation results and performance analysis are also included to support our developments. Copyright © 2010 John Wiley & Sons, Ltd.
Cryptanalysis of Hsiang‐Shih's authentication scheme for multi‐server architecture
Authors: Yeh Kuo‐Hui , Lo N. W. , Li Yingjiu 
Published: October 2010

AbstractFrom user point of view, password‐based remote user authentication technique is one of the most convenient and easy‐to‐use mechanisms to provide necessary security on system access. As the number of computer crimes in modern cyberspace has increased dramatically, the robustness of password‐based authentication schemes has been investigated by industries and organizations in recent years. In this paper, a well‐designed password‐based authentication protocol for multi‐server communication environment, introduced by Hsiang and Shih, is evaluated. Our security analysis indicates that their scheme is insecure against session key disclosure, server spoofing attack, and replay attack and behavior denial. Copyright © 2010 John Wiley & Sons, Ltd.