bluuebunny/crossref_metadata_2025_split huggingface dataset:
Neurotrophic keratopathy associated with congenital agenesis of the corpus callosum
Authors: HERRERO LATORRE R , GARCIA‐MARTIN E , DE LA MATA G , SATUE M , BAMBO MP , ARA M , EGEA MC , FERNANDEZ‐PEREZ S , PUEYO V 
Published: August 2012

AbstractPurpose The corpus callosum (CC), with its central position in the cerebrum, has an essential role in relaying sensory, motor, and cognitive information from homologous brain regions across cerebral hemispheres. Corpus callosum agenesis (CCA) is a rare congenital malformation which is caused by an alteration in embryonic development.Methods We report the case of a 3 year old child who was diagnosed of complete corpus callosum agenesis with a normal karyotype. The neurological findings were spastic tetraparesis with dystonia, several delayed psychomotor and epilepsy. In ophthalmology examination he presented esotropia, bilateral optic nerve hypoplasia, delayed visual evoked potential flash type and altered corneal sensibility in both eyes which is manifested clinically by recurrent corneal ulcers and epithelial disruption associated with stromal edema.Results After Neurotrophic keratopathy suspected, treatment with autologous serum was decided and response to treatment was favorable in both eyes with closure of ulcers and good management of symptoms. CCA has also been described in association with other ocular abnormalities such as optic nerve hypoplasia, retinal detachments, cataracts, morning glory syndrome, iris and optic nerve colobomas, among many others.Conclusion In all patients diagnosed with agenesis of the corpus callosum, the possible alteration of corneal sensitibility is a fact that will be suspected to perform early diagnosis and appropriate treatment and follow‐up.
Altered functional connectivity of primary visual cortex in adult comitant strabismus using resting‐functional mri
Authors: YAN X , LIN X , ZHOU Y , LIU Y , JIANG T 
Published: August 2012

AbstractPurpose Strabismus is not only associated with an abnormal eye position, but also with abnormal eye movement and poor stereopsis, both of which may be associated with high brain function. The aim of this study was to examine the functional connectivity between primary visual cortex and other cortical areas during rest in normal subjects and patients with comitant strabismus using functional magnetic resonance imaging.Methods Functional magnetic resonance imaging (fMRI) was carried out on ten patients with comitant exotropia and eleven well‐matched healthy subjects while all were in a resting state. The primary visual cortex was selected as the region of interest and the resting‐state functional connectivities of this area were analyzed.Results Compared with normal controls, strabismic patients showed that left BA17 had decreased functional connectivity with the right parietal lobe, left middle frontal gyrus, left superior frontal gyrus and right cerebellum, while the functional connectivity of the right BA17 was decreased at the middle frontal gyri bilaterally and the left inferior frontal gyrus. Enhanced connectivity of right BA17 to the bilateral middle occipital gyrus was also identified.Conclusion These data suggest that functional dysconnectivity between primary visual cortex and other cortical areas may exist in patients with comitant strabismus, and the abnormal connectivity may be associated with abnormal eye movement and loss of stereopsis.
Enigmatic reticulated filaments in subsurface granite
Authors: Miller A. Z. , Hernández‐Mariné M. , Jurado V. , Dionísio A. , Barquinha P. , Fortunato E. , Afonso M. J. , Chaminé H. I. , Saiz‐Jimenez C. 
Published: August 2012

SummaryIn the last few years, geomicrobiologists have focused their researches on the nature and origin of enigmatic reticulated filaments reported in modern and fossil samples from limestone caves and basalt lava tubes. Researchers have posed questions on these filaments concerning their nature, origin, chemistry, morphology, mode of formation and growth. A tentative microbial origin has been elusive since these filaments are found as hollow tubular sheaths and could not be affiliated to any known microorganism. We describe the presence of similar structures in a 16th century granite tunnel in Porto, Northwest Portugal. The reticulated filaments we identify exhibit fine geometry surface ornamentation formed by cross‐linked Mn‐rich nanofibres, surrounded by a large amount of extracellular polymeric substances. Within these Mn‐rich filaments we report for the first time the occurrence of microbial cells.
Short‐term results of laparoscopic surgery after preoperative chemoradiation for clinically staged T3 and T4 rectal cancer
Authors: Hotchi Masanori , Shimada Mitsuo , Kurita Nobuhiro , Iwata Takashi , Sato Hirohiko , Morimoto Shinya , Yoshikawa Kozo , Higashijima Jun , Miyatani Tomohiko , Mikami Chie , Kashihara Hideya 
Published: August 2012

AbstractIntroductionThe feasibility of laparoscopic surgery for clinically staged T3 and T4 rectal cancer has not been clearly defined specifically in cases following preoperative chemoradiation therapy (CRT). Our aim was to investigate the feasibility of laparoscopic surgery after preoperative CRT for clinically staged T3 and T4 rectal cancer.MethodsBetween May 2003 and June 2009, 57 patients (T3: n = 50, T4: n = 7) who underwent preoperative CRT for rectal cancer were identified. Forty‐three patients with laparoscopic surgery (Lap group) were compared with 14 patients who underwent open surgery (Open group). Perioperative data including postoperative morbidity were assessed between the two groups.ResultsAll patients underwent complete laparoscopic operations, and none was converted to laparotomy. Operating time was longer in the Open group (331 vs 375 min, P < 0.01). Blood loss was lower in the Lap group (160 vs 316 mL, P < 0.01). Lymph node harvest and morbidity rate were similar in both groups. The distal tumor margin was negative in all patients. No patients had perioperative mortality associated with surgery after CRT.ConclusionLaparoscopic surgery after preoperative CRT is a feasible and a safe option for T3 and T4 rectal cancer compared to conventional open surgery.
HIV and dentistry in Australia: clinical and legal issues impacting on dental care
Authors: McLean AT , Wheeler EK , Cameron S , Baker D 
Published: August 2012

AbstractThe number of people in Australia living with HIV is growing. This reflects a consistent rate of new HIV infections combined with an increased life expectancy of people with HIV. Dentists are ideally positioned to identify, manage and treat HIV‐associated oral manifestations and have a responsibility to themselves and to their patients to be up‐to‐date with the evolving area of HIV and related issues. Those issues include medico‐legal implications associated with HIV diagnosis and treatment. This article provides a review of the current clinical and medico‐legal aspects of HIV in Australia. The oral manifestations of HIV can be divided into five categories: microbiological infections (fungal, bacterial and viral); oral neoplasms; neurological conditions; other oral conditions that may be associated with HIV infection; and oral conditions associated with HIV treatment. Current treatment options in the scope of general dental practice are outlined. Medico‐legal issues related to the management of patients with HIV are explored, including rights of the patient regarding disclosure of HIV status; an algorithm for the management of a patient with signs or symptoms indicating possible HIV infection, including referral pathways; and an algorithm for dealing with patient management and referral issues.
The importance of a thorough medical and pharmacological history before dental implant placement
Authors: Zadik Y , Abu‐Tair J , Yarom N , Zaharia B , Elad S 
Published: August 2012

AbstractThe risk of osteonecrosis in patients treated with bisphosphonates is well known and guidelines intended to prevent this complication have been established and accepted. Bisphosphonate related osteonecrosis of the jaws (BRONJ) is a unique condition in which even past administration of medication may be of current and future relevance. We present a case of BRONJ in the maxilla after dental implant placement. The patient suffered from osteoporosis and had been treated with oral alendronate sodium in the past. However, the medication was stopped two years before implant placement, and the treating dentist was unaware of the patient’s past bisphosphonate use. Prevention of BRONJ is based on identifying at‐risk patients, and then avoiding or modifying dentoalveolar surgical procedures in these individuals. Nevertheless, there seems to be some difficulties identifying patients at risk. We present some of the challenges that impede thorough assessment of a patient’s medical background (review of systems) in the dental office, and suggest possible solutions.
The impact of automation on pharmacy staff experience of workplace stressors
Authors: James K Lynette , Barlow Dave , Bithell Anne , Hiom Sarah , Lord Sue , Oakley Pat , Pollard Mike , Roberts Dave , Way Cheryl , Whittlesea Cate 
Published: August 2012

Abstract

Objective
Determine the effect of installing an original pack automated dispensing system (ADS) on staff experience of occupational stressors.

Methods
Pharmacy staff in a National Health Service hospital in Wales, UK, were administered an anonymous occupational stressor questionnaire pre- (n = 45) and post-automation (n = 32). Survey responses pre- and post-automation were compared using Mann–Whitney U test. Statistical significance was P ≤ 0.05. Four focus groups were conducted (two groups of accredited checking technicians (ACTs) (group 1: n = 4; group 2: n = 6), one group of pharmacists (n = 17), and one group of technicians (n = 4) post-automation to explore staff experiences of occupational stressors. Focus group transcripts were analysed according to framework analysis.

Key findings
Survey response rate pre-automation was 78% (n = 35) and 49% (n = 16) post-automation. Automation had a positive impact on staff experience of stress (P = 0.023), illogical workload allocation (P = 0.004) and work–life balance (P = 0.05). All focus-group participants reported that automation had created a spacious working environment. Pharmacists and ACTs reported that automation had enabled the expansion of their roles. Technicians felt like ‘production-line workers.’ Robot malfunction was a source of stress.

Conclusion
The findings suggest that automation had a positive impact on staff experience of stressors, improving working conditions and workload. Technicians reported that ADS devalued their skills. When installing ADS, pharmacy managers must consider the impact of automation on staff. Strategies to reduce stressors associated with automation include rotating staff activities and role expansions.
Use of systemic medication in patients with oral lichen planus – a possible association with hypothyroidism
Authors: Robledo‐Sierra J , Mattsson U , Jontell M 
Published: August 2012

BackgroundSeveral drugs have been regarded as a possible aetiological factor for oral lichen planus (OLP).ObjectiveTo investigate the medication profile of patients with OLP and its possible association with the pathogenesis of OLP.MethodsData from 956 patients with OLP and 1029 controls were collected using a standardized registration method. All regular medications were recorded and classified according to the Anatomical Therapeutic Chemical Classification System.ResultsPatients with OLP used thyroid preparations (P < 0.001) and non‐steroidal anti‐inflammatory drugs (NSAIDs) (P < 0.01) in higher proportions compared to controls. A multivariate logistic regression model demonstrated that levothyroxine was associated with OLP (multivariate OR 3.39, 95% CI: 2.09–5.46, P < 0.001), even after controlling for confounders, including age, sex, smoking, allergies and systemic diseases. No statistical significance could be found between NSAIDs and OLP using the same model.ConclusionIn this study, the use of levothyroxine was associated with OLP, which in turn suggests a possible connection with hypothyroidism.
3-MANIFOLD GROUPS, KÄHLER GROUPS AND COMPLEX SURFACES
Authors: BISWAS INDRANIL , MJ MAHAN , SESHADRI HARISH 
Published: August 2012

Let G be a Kähler group admitting a short exact sequence [Formula: see text] where N is finitely generated. (i) Then Q cannot be non-nilpotent solvable. (ii) Suppose in addition that Q satisfies one of the following: (a) Q admits a discrete faithful non-elementary action on ℍn for some n ≥ 2. (b) Q admits a discrete faithful non-elementary minimal action on a simplicial tree with more than two ends. (c) Q admits a (strong-stable) cut R such that the intersection of all conjugates of R is trivial. Then G is virtually a surface group. It follows that if Q is infinite, not virtually cyclic, and is the fundamental group of some closed 3-manifold, then Q contains as a finite index subgroup either a finite index subgroup of the three-dimensional Heisenberg group or the fundamental group of the Cartesian product of a closed oriented surface of positive genus and the circle. As a corollary, we obtain a new proof of a theorem of Dimca and Suciu in [Which 3-manifold groups are Kähler groups? J. Eur. Math. Soc.11 (2009) 521–528] by taking N to be the trivial group. If instead, G is the fundamental group of a compact complex surface, and N is finitely presented, then we show that Q must contain the fundamental group of a Seifert-fibered 3-manifold as a finite index subgroup, and G contains as a finite index subgroup the fundamental group of an elliptic fibration. We also give an example showing that the relation of quasi-isometry does not preserve Kähler groups. This gives a negative answer to a question of Gromov which asks whether Kähler groups can be characterized by their asymptotic geometry.
GLOBAL PROPERTIES FOR A CLASS OF LATENT HIV INFECTION DYNAMICS MODEL WITH CTL IMMUNE RESPONSE
Authors: DONG YUEPING , MA WANBIAO 
Published: August 2012

M. M. Hadjiandreou, R. Conejeros and V. S. Vassiliadis (Math. Biosci. Eng. 4 (2007) 489–504) proposed an ODE model of long-term HIV infection dynamics. This model considers all important population compartments including macrophages, latently-infected CD4+ T cells and cytotoxic T lymphocytes (CTLs), which in many respects is novel in the field of mathematical modeling of HIV infection. The purpose of the paper is to simplify their model into a five-dimensional HIV dynamics model, and give a detailed classification on the existence of the equilibria of the reduced model by introducing four reproductive numbers. Then the global asymptotic stability of each equilibrium is analyzed by constructing suitable Lyapunov functions. The results in the paper extend and improve the understanding of the dynamics of HIV latency.
Decoupling algorithms from schedules for easy optimization of image processing pipelines
Authors: Ragan-Kelley Jonathan , Adams Andrew , Paris Sylvain , Levoy Marc , Amarasinghe Saman , Durand Frédo 
Published: August 2012

Using existing programming tools, writing high-performance image processing code requires sacrificing readability, portability, and modularity. We argue that this is a consequence of conflating what computations define the
algorithm
, with decisions about
storage
and the
order
of computation. We refer to these latter two concerns as the
schedule
, including choices of tiling, fusion, recomputation vs. storage, vectorization, and parallelism.

We propose a representation for feed-forward imaging pipelines that separates the algorithm from its schedule, enabling high-performance without sacrificing code clarity. This decoupling simplifies the algorithm specification: images and intermediate buffers become functions over an infinite integer domain, with no explicit storage or boundary conditions. Imaging pipelines are compositions of functions. Programmers separately specify scheduling strategies for the various functions composing the algorithm, which allows them to efficiently explore different optimizations without changing the algorithmic code.
We demonstrate the power of this representation by expressing a range of recent image processing applications in an embedded domain specific language called Halide, and compiling them for ARM, x86, and GPUs. Our compiler targets SIMD units, multiple cores, and complex memory hierarchies. We demonstrate that it can handle algorithms such as a camera raw pipeline, the bilateral grid, fast local Laplacian filtering, and image segmentation. The algorithms expressed in our language are both shorter and faster than state-of-the-art implementations.
Bounded distortion mapping spaces for triangular meshes
Authors: Lipman Yaron 
Published: August 2012

The problem of mapping triangular meshes into the plane is fundamental in geometric modeling, where planar deformations and surface parameterizations are two prominent examples. Current methods for triangular mesh mappings cannot, in general, control the worst case distortion of all triangles nor guarantee injectivity.
This paper introduces a constructive definition of generic convex spaces of piecewise linear mappings with guarantees on the maximal conformal distortion, as-well as local and global injectivity of their maps. It is shown how common geometric processing objective functionals can be restricted to these new spaces, rather than to the entire space of piecewise linear mappings, to provide a bounded distortion version of popular algorithms.
Video streaming using a location-based bandwidth-lookup service for bitrate planning
Authors: Riiser Haakon , Endestad Tore , Vigmostad Paul , Griwodz Carsten , Halvorsen Pâl 
Published: August 2012

A lot of people around the world commute using public transportation and would like to spend this time viewing streamed video content such as news or sports updates. However, mobile wireless networks typically suffer from severe bandwidth fluctuations, and the networks are often completely unresponsive for several seconds, sometimes minutes. Today, there are several ways of adapting the video bitrate and thus the video quality to such fluctuations, for example, using scalable video codecs or segmented adaptive HTTP streaming that switches between nonscalable video streams encoded in different bitrates. Still, for a better long-term video playout experience that avoids disruptions and frequent quality changes while using existing video adaptation technology, it is desirable to perform bandwidth prediction and planned quality adaptation.
This article describes a video streaming system for receivers equipped with a GPS. A receiver's download rate is constantly monitored, and periodically reported back to a central database along with associated GPS positional data. Thus, based on the current location, a streaming device can use a GPS-based bandwidth-lookup service in order to better predict the near-future bandwidth availability and create a schedule for the video playout that takes likely future availability into account. To create a prototype and perform initial tests, we conducted several field trials while commuting using public transportation. We show how our database has been used to predict bandwidth fluctuations and network outages, and how this information helps maintain uninterrupted playback with less compromise on video quality than possible without prediction.
Ultra-high resolution HLA genotyping and allele discovery by highly multiplexed cDNA amplicon pyrosequencing
Authors: Lank Simon M , Golbach Brittney A , Creager Hannah M , Wiseman Roger W , Keskin Derin B , Reinherz Ellis L , Brusic Vladimir , O’Connor David H 
Published: August 2012

Abstract

Background
High-resolution HLA genotyping is a critical diagnostic and research assay. Current methods rarely achieve unambiguous high-resolution typing without making population-specific frequency inferences due to a lack of locus coverage and difficulty in exon-phase matching. Achieving high-resolution typing is also becoming more challenging with traditional methods as the database of known HLA alleles increases.

Results
We designed a cDNA amplicon-based pyrosequencing method to capture 94% of the HLA class I open-reading-frame with only two amplicons per sample, and an analogous method for class II HLA genes, with a primary focus on sequencing the DRB loci. We present a novel Galaxy server-based analysis workflow for determining genotype. During assay validation, we performed two GS Junior sequencing runs to determine the accuracy of the HLA class I amplicons and DRB amplicon at different levels of multiplexing. When 116 amplicons were multiplexed, we unambiguously resolved 99%of class I alleles to four- or six-digit resolution, as well as 100% unambiguous DRB calls. The second experiment, with 271 multiplexed amplicons, missed some alleles, but generated high-resolution, concordant typing for 93% of class I alleles, and 96% for DRB1 alleles. In a third, preliminary experiment we attempted to sequence novel amplicons for other class II loci with mixed success.

Conclusions
The presented assay is higher-throughput and higher-resolution than existing HLA genotyping methods, and suitable for allele discovery or large cohort sampling. The validated class I and DRB primers successfully generated unambiguously high-resolution genotypes, while further work is needed to validate additional class II genotyping amplicons.
Vitamin E and telmisartan attenuates doxorubicin induced cardiac injury in rat through down regulation of inflammatory response
Authors: Hadi Najah , Yousif Nasser Ghaly , Al-amran Fadhil G , Huntei Nadhem K , Mohammad Bassim I , Ali Sadiq J 
Published: August 2012

Abstract

Background
The importance of doxorubicin (Dox), as a potent antitumor antibiotic, is limited by the development of life-threatening cardiomyopathy. It has been shown that free radicals are involved in acute doxorubicin-induced toxicity. The aim of this study was to determine the protective effect of vitamin E and telmisartan in acute doxorubicin induced cardiotoxicity.

Methods
Thirty two male Sprague - Dawly rats were involved in this study and were randomly separated into 4 groups, eight rats in each group, one group received normal saline I.P as control and second group received doxorubicin 20 mg/kg I.P, the other two groups also received doxorubicin 20 mg/kg I.P as single dose after seven cumulative doses (for seven days) of vitamin E (100 mg/kg) and telmisartan (1 mg/kg) respectively. Immunofluorescent staining for monocytes infiltration and analyses of plasma by (ELISAs) for MCP-1and troponin I. Western immunoblotting assay for ICAM-1, while left ventricular function was analyzed by microcatheter, also estimated the level of oxidative stress parameters (MDA and Catalase) and cardiac enzymes activities (CK-MB and LDH) before starting drugs treatment and after treatment period by 48 hours.

Results
The immunofluorescent staining showed that administration of vitamin E and telmisartan are attenuated of mononuclear cell infiltration; (p < 0.05 vs. Dox group), also reduced the level of chemokines MCP-1 and ICAM-1 expression compared with Dox group only, and there is marked reduction of myocardial troponin-I levels with improved LV function in vitamin E and telmisartan treated group. Doxorubicin treatment increased MDA, LDH, CK-MB levels significantly (P < 0.01), and were counteracted by administration of vitamin E and telmisartan, but did not significantly affect serum catalase activity.

Conclusions
Antioxidant effect (Vitamin E and telmisartan) have been shown to decrease doxorubicininduced cardiotoxicity.