bluuebunny/crossref_metadata_2025_split huggingface dataset:
Intraoperative Neuromonitoring for Early Localization and Identification of Recurrent Laryngeal Nerve During Thyroid Surgery
Authors: Chiang Feng‐Yu , Lu I‐Cheng , Chen Hui‐Chun , Chen Hsiu‐Ya , Tsai Cheng‐Jing , Lee Ka‐Wo , Hsiao Pi‐Jung , Wu Che‐Wei 
Published: December 2010

AbstractEarly and definite identification of the recurrent laryngeal nerve (RLN) is an important step to avoid inadvertent nerve injury during complicated thyroid operations. This study aimed to determine the feasibility of routine use of intraoperative neuromonitoring (IONM) to localize and identify the RLN at an early stage of thyroid surgery. This prospective study enrolled 220 consecutive patients (333 RLNs at risk) who underwent thyroid operations with application of IONM. The RLN was localized and identified routinely with a nerve stimulator after opening the space between the thyroid and carotid sheath. The success rates of early RLN localization and identification were evaluated. The current for localization and the amplitude of evoked laryngeal electromyographic signals were also recorded and analyzed. All RLNs, including 87 (26%) nerves that were regarded as difficult to identify, were successfully localized and identified. The stimulation level for RLN localization was 2mA in 315 nerves (95%) and 3mA in the other 18 nerves (5%). The signal obtained from RLN localization (amplitude = 932 ±436μV) showed a clear and reliable laryngeal electromyographic response that was similar to that from direct vagus (amplitude=811±389μV) or RLN stimulation (amplitude=1132±472μV). The palsy rate was 0.6% and no permanent palsy occurred. RLN injury is rare if the nerve is definitely identified early in the thyroid operation. The conclusion of this study is that IONM is a reliable tool for early RLN localization and identification, even in complicated thyroid operations.
Electromyographic Study of Differential Sensitivity to Succinylcholine of the Diaphragm, Laryngeal and Somatic Muscles: A Swine Model
Authors: Lu I‐Cheng , Wang Hsun‐Mo , Kuo Yi‐Wei , Shieh Chia‐Fang , Chiang Feng‐Yu , Wu Che‐Wei , Tsai Cheng‐Jing 
Published: December 2010

AbstractNeuromuscular blocking agents (NMBAs) might diminish the electromyography signal of the vocalis muscles during intraoperative neuromonitoring of the recurrent laryngeal nerve. The aim of this study was to compare differential sensitivity of different muscles to succinylcholine in a swine model, and to realize the influence of NMBAs on neuromonitoring. Six male Duroc‐Landrace piglets were anesthetized with thiamylal and underwent tracheal intubation without the use of an NMBA. The left recurrent laryngeal nerve, the spinal accessory nerve, the right phrenic nerve and the brachial plexus were stimulated. Evoked potentials (electromyography signal) of four muscle groups were elicited from needle electrodes before and after intravenous succinylcholine bolus (1.0 mg/kg). Recorded muscles included the vocalis muscles, trapezius muscle, diaphragm and triceps brachii muscles. The onset time and 80% recovery of control response were recorded and analyzed. The testing was repeated after 30 minutes. The onset time of neuromuscular blocking for the vocalis muscles, trapezius muscle, diaphragm and triceps brachii muscle was 36.3 ± 6.3 seconds, 38.8 ± 14.9 seconds, 52.5 ± 9.7 seconds and 45.0 ± 8.2 seconds during the first test; and 49.3 ± 10.8 seconds, 40.0 ± 12.2 seconds, 47.5 ± 11.9 seconds and 41.3 ± 10.1 seconds during the second test. The 80% recovery of the control response for each muscle was 18.3 ± 2.7 minutes, 16.5±6.9 minutes, 8.1±2.5 minutes and 14.8±2.9 minutes during the first test; and 21.5±3.8 minutes, 12.5 ± 4.3 minutes, 10.5 ± 3.1 minutes and 16.4 ± 4.2 minutes during the second test. The sensitivity of the muscles to succinylcholine, ranked in order, was: the vocalis muscles, the triceps brachii muscle, the trapezius muscle and the diaphragm. We demonstrated a useful and reliable animal model to investigate the effects of NMBAs on intraoperative neuromonitoring. Extrapolation of these data to humans should be done with caution.
Immigration Distress and Associated Factors Among Vietnamese Women in Transnational Marriages in Taiwan
Authors: Yang Yung‐Mei , Wang Hsiu‐Hung , Anderson Debra 
Published: December 2010

AbstractThe purpose of this study was to explore the types and predictors of immigration distress among Vietnamese women in transnational marriages in Taiwan. A cross‐sectional survey with face‐to‐face interviews was conducted for data collection. A convenient sample of 203 Vietnamese women in transnational marriages in southern Taiwan was recruited. The Demographic Inventory measured the participants' age, education, employment status, religion, length of residency and number of children, as well as their spouse's age, education, employment status and religion. The Demand of Immigration Specific Distress scale measured the level of distress and had six subscales: loss, novelty, occupational adjustment, language accommodation, discrimination and alienation. Among the 203 participants, 6.4% had a high level of immigration distress; 91.1% had moderate distress; and 2.5% had minor distress. Higher mean scores were found for the loss, novelty and language accommodation subscales of the Demand of Immigration Specific Distress scale. Participant's (r = 0.321, p < 0.01) and spouse's (r = 0.375, p < 0.01) unemployment, and more children (r = 0.129, p < 0.05) led to greater immigration distress. Length of residency in Taiwan (r = 0.576, p < 0.001) was an effective predictor of immigration distress. It indicated that the participants who had stayed fewer years in Taiwan had a higher level of immigrant distress. Health care professionals need to be aware that the female newcomers in transnational marriages are highly susceptible to immigration distress. The study suggests that healthcare professionals need to provide a comprehensive assessment of immigration distress to detect health problems early and administer culturally appropriate healthcare for immigrant women in transnational marriages.
Anorectal Malignant Melanomas: Experience of Uludag University
Authors: Aytac Berna , Adim Saduman Balaban , Yerci Omer , Yilmazlar Tuncay 
Published: December 2010

AbstractAnorectal melanomas represent a group of mucosal melanomas with unknown etiology and poor prognosis. The lesions can be misdiagnosed as hemorrhoids during clinical examination. We reviewed the morphological and clinical features of 14 anorectal melanomas, and discuss the treatment modalities of this entity. Fourteen patients who were diagnosed with anorectal malignant melanoma between 1997 and 2004 were evaluated with regard to age, sex, size, morphology, lymph node or distant metastasis, treatment modality and survival. Eight patients were female and six were male, and their mean age was 58 years. The size of melanoma ranged from 3 cm to 8 cm. Pathological evaluation revealed epithelioid and spindle cell type tumor in seven and two patients, respectively, whereas, in the remaining seven patients, the tumor was composed of both types. Pigmentation was apparent in all tumors. There was lymph node metastasis in 11 patients and distant metastasis in all patients. Eleven patients underwent abdominoperineal resection and three were treated by local excision. Mean survival was 8.7 months. Prognosis of anorectal melanoma remains poor. Awareness of the diverse clinicopathological features of these lesions, both on the part of the clinicians and pathologists, is crucial for their early detection and proper treatment.
Multiple Organ Infarctions Following Disseminated Intravascular Coagulation Precipitated by Sepsis in A Healthy Infant: A Case Report
Authors: Wang Chien‐Hua , Lee Min‐Sheng , Lin Lung‐Chang , Yang Rei‐Cheng 
Published: December 2010

AbstractMultiple organ infarctions are a very rare clinical event in children. We report a 3‐month‐old infant with sepsis and disseminated intravascular coagulation, who was diagnosed with cerebral ischemic stroke associated with middle cerebral artery stenosis and subsequent retinal infarction by magnetic resonance imaging, fundoscopy and magnetic resonance angiography. In addition, he suffered from renal infarction with hypertension and was treated until 1 year of age. We emphasize the importance of early recognition of organ infarctions, prophylaxis of risk factors and of optimized therapy of the underlying etiology.
Subcutaneous Emphysema, Pneumothorax, Pneumomediastinum, and Pneumoperitoneum During Colonoscopic Balloon Dilation: A Case Report
Authors: Chan Yi‐Chen , Tsai Yu‐Chuan , Fang Shih‐Yuan 
Published: December 2010

AbstractA 77‐year‐old woman underwent colonoscopic balloon dilatation for colonic stricture 1 year after laparoscopic anterior resection of sigmoid colon cancer. During the balloon dilatation, panfacial swelling and apnea were noted. Emergency endotracheal intubation was undertaken. Chest X‐ray revealed diffuse subcutaneous emphysema and bilateral pneumothorax. We discuss the possible mechanism and management of this uncommon complication during therapeutic colonoscopy.
Malignant Melanoma of the Choroid in the Eye With Oculodermal Melanocytosis of a Chinese Woman
Authors: Chen Ya‐Chi , Chang Cheng‐Hsien , Hsu Shiuh‐Liang , Hsu Min‐Wen , Lee Chia‐Ling 
Published: December 2010

AbstractIn this study, we report a rare case of choroidal melanoma in an eye with oculodermal melanocytosis (Nevus of Ota). A 56‐year‐old Taiwanese woman with oculodermal melanocytosis in the right eye was found to have an ipsilateral uveal melanoma. Histopathology of the enucleated eye confirmed the diagnosis of malignant choroidal melanoma of mixed cell type. A search of the literature revealed strong evidence that oculodermal melanocytosis can predispose to the development of uveal melanoma in Caucasians. Only seven such cases have been reported in the East Asian population. This is believed to be the first such reported case in a patient of Chinese descent.
Spontaneous Internal Jugular Vein Thrombosis: A Case Report
Authors: Serinken Mustafa , Karcioglu Ozgur , Korkmaz Ayhan 
Published: December 2010

AbstractInternal jugular vein thrombosis (IJVT) is an elusive vascular disease that is rarely seen, with potentially lethal complications such as sepsis and pulmonary embolism. Spontaneous IJVT is considered when no apparent predisposing cause of thrombosis is present. A previously healthy, 31‐year‐old woman presented to the university‐based emergency department because of painless swelling in the right anterior side of her neck. Physical examination revealed a painless, soft and immobile mass in the right anterior side of her neck beneath the sternocleidomastoid muscle, without hyperemia or local heat. On ultrasonographic examination, a hyperechogenic mass was visualized around the thoracic entrance of the right internal jugular vein, which was suggestive of a thrombus. The patient was administered intravenous antibiotic and low‐molecular‐weight heparin followed by oral coumadin as anticoagulant therapy. Her complaints were relieved within 5 days. She was completely well after 6 months. Venous thrombosis generally results from impaired blood flow locally or systemically that leads to activation of coagulation. Primary care physicians should sustain a high index of suspicion in patients who present with undiagnosed swelling in the neck, or other signs and symptoms attributed to IJVT.
Formation of benzene in the interstellar medium
Authors: Jones Brant M. , Zhang Fangtong , Kaiser Ralf I. , Jamal Adeel , Mebel Alexander M. , Cordiner Martin A. , Charnley Steven B. 
Published: December 2010

Polycyclic aromatic hydrocarbons and related species have been suggested to play a key role in the astrochemical evolution of the interstellar medium, but the formation mechanism of even their simplest building block—the aromatic benzene molecule—has remained elusive for decades. Here we demonstrate in crossed molecular beam experiments combined with electronic structure and statistical calculations that benzene (C
6
H
6
) can be synthesized via the barrierless, exoergic reaction of the ethynyl radical and 1,3-butadiene, C
2
H + H
2
CCHCHCH
2
→ C
6
H
6
+ H, under single collision conditions. This reaction portrays the simplest representative of a reaction class in which aromatic molecules with a benzene core can be formed from acyclic precursors via barrierless reactions of ethynyl radicals with substituted 1,3-butadiene molecules. Unique gas-grain astrochemical models imply that this low-temperature route controls the synthesis of the very first aromatic ring from acyclic precursors in cold molecular clouds, such as in the Taurus Molecular Cloud. Rapid, subsequent barrierless reactions of benzene with ethynyl radicals can lead to naphthalene-like structures thus effectively propagating the ethynyl-radical mediated formation of aromatic molecules in the interstellar medium.
Researching and implementing a new tiered pricing model
Authors: RAPPLE Charlie 
Published: December 2010

ABSTRACTTiered pricing can help to arrest the revenue decline associated with the transition from print to online subscriptions. This case study reviews the objectives, challenges, project phases, impact, and key lessons of a project to research and implement a new tiered pricing model for a society publisher. We analysed current sales and profiled institutional subscribers to define, model, and refine appropriate price tiers. This led to the introduction of fair and transparent pricing that encourages usage, is manageable for supply chain stakeholders and minimizes the need for custom licences. We then planned and implemented a segmented communications strategy to increase current customer awareness of and support for the new pricing, and identified prospective customers and segments for potential sales growth.
E‐journals, researchers — and the new librarians
Authors: NICHOLAS David , ROWLANDS Ian , WILLIAMS Peter 
Published: December 2010

ABSTRACTThis paper provides the results of a two‐year investigation into the use of e‐journals by the UK research community. Log analysis, questionnaires, interviews, and observation were used to collect the information. The results are presented in a FAQ format to make the key findings accessible. The main findings are that journals have become central to most disciplines, and that the e‐form has become the prime means of access. The results for history suggest that the old scholarly communication mantras (scientists primarily communicate through articles, historians through monographs) are rapidly breaking down. Indeed, all researchers seem addicted to journal content. Research without this resource now seems unthinkable; journals are a researcher's lifeblood. Gateway services, hugely popular in science, are re‐intermediating the broken chain between publisher and reader; they are the new librarians.
Avoiding a Digital Dark Age for data: why publishers should care about digital preservation
Authors: SMIT Eefke , VAN DER HOEVEN Jeffrey , GIARETTA David 
Published: December 2010

ABSTRACTThis paper provides an overview of the needs and threats for digital preservation and summarizes the findings from project PARSE.Insight. This project, co‐funded by the EU, contains one of the first large worldwide surveys about digital preservation including most players of the STM information chain: researchers, libraries, data managers, publishers, and research funders. One of the conclusions is that in the present data deluge, it is extremely important that all players in the information chain work together on proper digital preservation of all research output, to ensure its future usability, understandability, and authenticity. This poses a new role for publishers who can ensure better discoverability and citability via good linking and integration of data and publications.
The ethics of scholarly peer review: a review of the literature
Authors: SOUDER Lawrence 
Published: December 2010

ABSTRACTThis review summarizes the literature of a subset of the published research and commentary on peer review – the ethics of peer review. It attempts to track the various ethical issues that arise among the key participants in peer‐review systems: authors, editors, referees, and readers. These issues include: bias, courtesy, conflict of interest, redundant publication, honesty, transparency, and training. It concludes that debates over such issues as open vs. blind reviews continue unresolved but that new technologies offer some prospects for resolving old issues while they also may create new challenges.
Ct3d: tracking microglia motility in 3D using a novel cosegmentation approach
Authors: Xiao Hang , Li Ying , Du Jiulin , Mosig Axel 
Published: December 2010

Abstract
Motivation: Cell tracking is an important method to quantitatively analyze time-lapse microscopy data. While numerous methods and tools exist for tracking cells in 2D time-lapse images, only few and very application-specific tracking tools are available for 3D time-lapse images, which is of high relevance in immunoimaging, in particular for studying the motility of microglia in vivo.
Results: We introduce a novel algorithm for tracking cells in 3D time-lapse microscopy data, based on computing cosegmentations between component trees representing individual time frames using the so-called tree-assignments. For the first time, our method allows to track microglia in three dimensional confocal time-lapse microscopy images. We also evaluate our method on synthetically generated data, demonstrating that our algorithm is robust even in the presence of different types of inhomogeneous background noise.
Availability: Our algorithm is implemented in the ct3d package, which is available under http://www.picb.ac.cn/patterns/Software/ct3d; supplementary videos are available from http://www.picb.ac.cn/patterns/Supplements/ct3d.
Contact: axel@picb.ac.cn; forestdu@ion.ac.cn
Supplementary information: Supplementary data are available at Bioinformatics online.
A computationally efficient modular optimal discovery procedure
Authors: Woo Sangsoon , Leek Jeffrey T. , Storey John D. 
Published: December 2010

Abstract
Motivation: It is well known that patterns of differential gene expression across biological conditions are often shared by many genes, particularly those within functional groups. Taking advantage of these patterns can lead to increased statistical power and biological clarity when testing for differential expression in a microarray experiment. The optimal discovery procedure (ODP), which maximizes the expected number of true positives for each fixed number of expected false positives, is a framework aimed at this goal. Storey et al. introduced an estimator of the ODP for identifying differentially expressed genes. However, their ODP estimator grows quadratically in computational time with respect to the number of genes. Reducing this computational burden is a key step in making the ODP practical for usage in a variety of high-throughput problems.
Results: Here, we propose a new estimate of the ODP called the modular ODP (mODP). The existing ‘full ODP’ requires that the likelihood function for each gene be evaluated according to the parameter estimates for all genes. The mODP assigns genes to modules according to a Kullback–Leibler distance, and then evaluates the statistic only at the module-averaged parameter estimates. We show that the mODP is relatively insensitive to the choice of the number of modules, but dramatically reduces the computational complexity from quadratic to linear in the number of genes. We compare the full ODP algorithm and mODP on simulated data and gene expression data from a recent study of Morrocan Amazighs. The mODP and full ODP algorithm perform very similarly across a range of comparisons.
Availability: The mODP methodology has been implemented into EDGE, a comprehensive gene expression analysis software package in R, available at http://genomine.org/edge/.
Contact: jstorey@princeton.edu
Supplementary information: Supplementary data are available at Bioinformatics online.
A sub-pathway-based approach for identifying drug response principal network
Authors: Chen Xiujie , Xu Jiankai , Huang Bangqing , Li Jin , Wu Xin , Ma Ling , Jia Xiaodong , Bian Xiusen , Tan Fujian , Liu Lei , Chen Sheng , Li Xia 
Published: December 2010

AbstractMotivation: The high redundancy of and high degree of cross-talk between biological pathways hint that a sub-pathway may respond more effectively or sensitively than the whole pathway. However, few current pathway enrichment analysis methods account for the sub-pathways or structures of the tested pathways. We present a sub-pathway-based enrichment approach for identifying a drug response principal network, which takes into consideration the quantitative structures of the pathways.Result: We validated this new approach on a microarray experiment that captures the transcriptional profile of dexamethasone (DEX)-treated human prostate cancer PC3 cells. Compared with GeneTrail and DAVID, our approach is more sensitive to the DEX response pathways. Specifically, not only pathways but also the principal components of sub-pathways and networks related to prostate cancer and DEX response could be identified and verified by literature retrieval.Contact: chenxiujie@ems.hrbmu.edu.cn; lixia@hrbmu.edu.cnSupplementary information: Supplementary data are available at Bioinformatics online.
Voroprot: an interactive tool for the analysis and visualization of complex geometric features of protein structure
Authors: Olechnovič Kliment , Margelevičius Mindaugas , Venclovas Česlovas 
Published: December 2010

Abstract
Summary: We present Voroprot, an interactive cross-platform software tool that provides a unique set of capabilities for exploring geometric features of protein structure. Voroprot allows the construction and visualization of the Apollonius diagram (also known as the additively weighted Voronoi diagram), the Apollonius graph, protein alpha shapes, interatomic contact surfaces, solvent accessible surfaces, pockets and cavities inside protein structure.
Availability: Voroprot is available for Windows, Linux and Mac OS X operating systems and can be downloaded from http://www.ibt.lt/bioinformatics/voroprot/.
Contact: venclovas@ibt.lt
PUGSVM: a caBIGTM analytical tool for multiclass gene selection and predictive classification
Authors: Yu Guoqiang , Li Huai , Ha Sook , Shih Ie−Ming , Clarke Robert , Hoffman Eric P. , Madhavan Subha , Xuan Jianhua , Wang Yue 
Published: December 2010

Abstract
Summary: Phenotypic Up-regulated Gene Support Vector Machine (PUGSVM) is a cancer Biomedical Informatics Grid (caBIG™) analytical tool for multiclass gene selection and classification. PUGSVM addresses the problem of imbalanced class separability, small sample size and high gene space dimensionality, where multiclass gene markers are defined by the union of one-versus-everyone phenotypic upregulated genes, and used by a well-matched one-versus-rest support vector machine. PUGSVM provides a simple yet more accurate strategy to identify statistically reproducible mechanistic marker genes for characterization of heterogeneous diseases.
Availability: http://www.cbil.ece.vt.edu/caBIG-PUGSVM.htm.
Contact: yuewang@vt.edu
Supplementary information: Supplementary data are available at Bioinformatics online.