bluuebunny/crossref_metadata_2025_split huggingface dataset:
Modeling children’s moral development in postwar Taiwan through naturalistic observations preserved in historical texts
Authors: Sui Zhining , Wang Qinyan , Xu Jing 
Published: April 2024

AbstractA core issue in the interdisciplinary study of human morality is its ontogeny in diverse cultures, but systematic, naturalistic data in specific cultural contexts are rare to find. This study conducts a novel analysis of 213 children’s socio-moral behavior in a historical, non-Western, rural setting, based on a unique dataset of naturalistic observations from the first field research on Han Chinese children. Using multilevel multinomial modeling, we examined a range of proactive behaviors in 0-to-12-year-old children’s peer cooperation and conflict in an entire community in postwar Taiwan. We modeled the effects of age, sex, kinship, and behavioral roles, and revealed complex interactions between these four variables in shaping children’s moral development. We discovered linkages between coercive and non-coercive behaviors as children strategically negotiated leadership dynamics. We identified connections between prosocial and aggressive behaviors, illuminating the nuances of morality in real life. Our analysis also revealed gendered patterns and age-related trends that deviated from cultural norms and contradicted popular assumptions about Chinese family values. These findings highlight the importance of naturalistic observations in cultural contexts for understanding how we become moral persons. This re-analysis of historically significant fieldnotes also enriches the interdisciplinary study of child development across societies.
Spontaneous Akt2 deficiency in a colony of NOD mice exhibiting early diabetes
Authors: Hervé Julie , Haurogné Karine , Allard Marie , Sourice Sophie , Lindenbaum Pierre , Bach Jean-Marie , Lieubeau Blandine 
Published: April 2024

AbstractDiabetes constitutes a major public health problem, with dramatic consequences for patients. Both genetic and environmental factors were shown to contribute to the different forms of the disease. The monogenic forms, found both in humans and in animal models, specially help to decipher the role of key genes in the physiopathology of the disease. Here, we describe the phenotype of early diabetes in a colony of NOD mice, with spontaneous invalidation of Akt2, that we called HYP. The HYP mice were characterised by a strong and chronic hyperglycaemia, beginning around the age of one month, especially in male mice. The phenotype was not the consequence of the acceleration of the autoimmune response, inherent to the NOD background. Interestingly, in HYP mice, we observed hyperinsulinemia before hyperglycaemia occurred. We did not find any difference in the pancreas’ architecture of the NOD and HYP mice (islets’ size and staining for insulin and glucagon) but we detected a lower insulin content in the pancreas of HYP mice compared to NOD mice. These results give new insights about the role played by Akt2 in glucose homeostasis and argue for the ß cell failure being the primary event in the course of diabetes.
A single-photon lidar observes atmospheric clouds at decimeter scales: resolving droplet activation within cloud base
Authors: Yang Fan , Kostinski Alex B. , Zhu Zeen , Lamer Katia , Luke Edward , Kollias Pavlos , Sua Yong Meng , Hou Pei , Shaw Raymond A. , Vogelmann Andrew M. 
Published: April 2024

AbstractClouds, crucial for understanding climate, begin with droplet formation from aerosols, but observations of this fleeting activation step are lacking in the atmosphere. Here we use a time-gated time-correlated single-photon counting lidar to observe cloud base structures at decimeter scales. Results show that the air–cloud interface is not a perfect boundary but rather a transition zone where the transformation of aerosol particles into cloud droplets occurs. The observed distributions of first-arriving photons within the transition zone reflect vertical development of a cloud, including droplet activation and condensational growth. Further, the highly resolved vertical profile of backscattered photons above the cloud base enables remote estimation of droplet concentration, an elusive but critical property to understanding aerosol–cloud interactions. Our results show the feasibility of remotely monitoring cloud properties at submeter scales, thus providing much-needed insights into the impacts of atmospheric pollution on clouds and aerosol-cloud interactions that influence climate.
Rummagene: massive mining of gene sets from supporting materials of biomedical research publications
Authors: Clarke Daniel J. B. , Marino Giacomo B. , Deng Eden Z. , Xie Zhuorui , Evangelista John Erol , Ma’ayan Avi 
Published: April 2024

AbstractMany biomedical research publications contain gene sets in their supporting tables, and these sets are currently not available for search and reuse. By crawling PubMed Central, the Rummagene server provides access to hundreds of thousands of such mammalian gene sets. So far, we scanned 5,448,589 articles to find 121,237 articles that contain 642,389 gene sets. These sets are served for enrichment analysis, free text, and table title search. Investigating statistical patterns within the Rummagene database, we demonstrate that Rummagene can be used for transcription factor and kinase enrichment analyses, and for gene function predictions. By combining gene set similarity with abstract similarity, Rummagene can find surprising relationships between biological processes, concepts, and named entities. Overall, Rummagene brings to surface the ability to search a massive collection of published biomedical datasets that are currently buried and inaccessible. The Rummagene web application is available at https://rummagene.com.
A practical synthesis of nitrone-derived C5a-functionalized isofagomines as protein stabilizers to treat Gaucher disease
Authors: Li Huang-Yi , Chen Wei-An , Lin Hung-Yi , Tsai Chi-Wei , Chiu Yu-Ting , Yun Wen-Yi , Lee Ni-Chung , Chien Yin-Hsiu , Hwu Wuh-Liang , Cheng Wei-Chieh 
Published: April 2024

AbstractIsofagomine (IFG) and its analogues possess promising glycosidase inhibitory activities. However, a flexible synthetic strategy toward both C5a-functionalized IFGs remains to be explored. Here we show a practical synthesis of C5a-S and R aminomethyl IFG-based derivatives via the diastereoselective addition of cyanide to cyclic nitrone 1. Nitrone 1 was conveniently prepared on a gram scale and in high yield from inexpensive (−)-diethyl d-tartrate via a straightforward method, with a stereoselective Michael addition of a nitroolefin and a Nef reaction as key steps. A 268-membered library (134 × 2) of the C5a-functionalized derivatives was submitted to enzyme- or cell-based bio-evaluations, which resulted in the identification of a promising β-glucocerebrosidase (GCase) stabilizer demonstrating a 2.7-fold enhancement at 25 nM in p.Asn370Ser GCase activity and a 13-fold increase at 1 μM in recombinant human GCase activity in Gaucher cell lines.
Last Interglacial subsurface warming on the Antarctic shelf triggered by reduced deep-ocean convection
Authors: Yeung Nicholas King-Hei , Menviel Laurie , Meissner Katrin J. , Choudhury Dipayan , Ziehn Tilo , Chamberlain Matthew A. 
Published: April 2024

AbstractThe Antarctic ice-sheet could have contributed 3 to 5 m sea-level equivalent to the Last Interglacial sea-level highstand. Such an Antarctic ice-mass loss compared to pre-industrial requires a subsurface warming on the Antarctic shelf of ~ 3 °C according to ice-sheet modelling studies. Here we show that a substantial subsurface warming is simulated south of 60 °S in an equilibrium experiment of the Last Interglacial. It averages +1.2 °C at ~ 500 m depth from 70 °W to 160 °E, and it reaches +2.4 °C near the Lazarev Sea. Weaker deep-ocean convection due to reduced sea-ice formation is the primary driver of this warming. The associated changes in meridional density gradients and surface winds lead to a weakened Antarctic Circumpolar Current and strengthened Antarctic Slope Current, which further impact subsurface temperatures. A subsurface warming on the Antarctic shelf that could trigger ice-mass loss from the Antarctic ice-sheet can thus be obtained during warm periods from reduced sea-ice formation.
MECSBO: Multi‐strategy enhanced circulatory system based optimisation algorithm for global optimisation and reliability‐based design optimisation problems
Authors: Yang Shiyuan , Guo Chenhao , Meng Debiao , Guo Yipeng , Guo Yongqiang , Pan Lidong , Zhu Shun‐Peng 
Published: April 2024

AbstractThe Circulatory System Based Optimisation (CSBO) stands as a nascent metaheuristic optimisation algorithm known for its proficiency in tackling global optimisation problems. The authors introduce the Multi‐strategy Enhanced CSBO (MECSBO), an algorithm designed for global optimisation and Reliability‐based Design Optimisation (RBDO). MECSBO integrates adaptive inertia weight, golden sine operator and chaos strategy to augment the convergence capacity and efficiency of the original CSBO. Furthermore, MECSBO‐based RBDO algorithm is presented to address RBDO problem. The comparative analysis utilising standard real‐world benchmark functions has been carried out to validate the effectiveness of the proposed MECSBO. Several RBDO problems, including three typical numerical examples and three engineering cases, are used to show abilities of the proposed MECSBO‐based RBDO algorithm. The results demonstrated that MECSBO is outperformed comparing to the state‐of‐the‐art algorithms in terms of accuracy, efficiency, and robustness in RBDO problems.
Energy efficient RF chains selection based on integrated Hungarian and genetic approaches for uplink cell‐free millimetre‐wave massive MIMO systems
Authors: Al Ayidh Abdulrahman , Alammar Mohammed M. 
Published: April 2024

AbstractThe purpose of this work is to explore the decrease of total used power in cell‐free millimetre‐wave (mm‐Wave) massive multiple‐input multiple‐output (MIMO) systems, which can be regarded an essential technology for future wireless generations to improve system performance. One of the most important strategies for reducing total power consumption is to activate and deactivate radio frequency (RF) chains at each access point (AP) in the coverage region. Nonetheless, the optimization issue for this methodology is NP‐hard, and an exhaustive search method may be used to determine the ideal number of RF chains at each AP in the cell‐free network. Unfortunately, the exhaustive searching approach is prohibitively complicated, indicating that it is unworkable when there are a significant number of APs in the service region. Furthermore, present RF chain selection approaches prioritize decreasing consumed power and complexity at the price of system performance in terms of total possible rate. This research solves this issue by introducing a unique RF chain selection approach that combines Hungarian and genetic algorithms. The fact that the genetic algorithm (GA) can readily determine the ideal number of active RF chains, yet this technique generally entails significant complexity in large‐scale cell‐free networks, prompted this notion. As a result, the Hungarian method is used early in the GA to overcome the complexity problem while still retaining system performance. In addition, the suggested system employs a semi‐centralized hybrid beamforming architecture in which all analogue combiners for all APs are operated at a central processing unit using channel state information. In addition, each AP has a fully linked phase shifters network and restricted RF chains connecting to its antennas. Finally, simulation findings reveal that, when compared to state‐of‐the‐art techniques, the suggested approach achieves the maximum attainable rate and overall energy efficiency with a tolerable computational complexity.
HGSNet: A hypergraph network for subtle lesions segmentation in medical imaging
Authors: Wang Junze , Zhang Wenjun , Li Dandan , Li Chao , Jing Weipeng 
Published: April 2024

AbstractLesion segmentation is a fundamental task in medical image processing, often facing the challenge of subtle lesions. It is important to detect these lesions, even though they can be difficult to identify. Convolutional neural networks, an effective method in medical image processing, often ignore the relationship between lesions, leading to topological errors during training. To tackle topological errors, move is made from pixel‐level to hypergraph representations. Hypergraphs can model lesions as vertices connected by hyperedges, capturing the topology between lesions. This paper introduces a novel dynamic hypergraph learning strategy called DHLS. DHLS allows for the dynamic construction of hypergraphs contingent upon input vertex variations. A hypergraph global‐aware segmentation network, termed HGSNet, is further proposed. HGSNet can capture the key high‐order structure information, which is able to enhance global topology expression. Additionally, a composite loss function is introduced. The function emphasizes the global aspect and the boundary of segmentation regions. The experimental setup compared HGSNet with other advanced models on medical image datasets from various organs. The results demonstrate that HGSNet outperforms other models and achieves state‐of‐the‐art performance on three public datasets.
Clinico-radiologic Spectrum and Outcome of Pediatric Acquired Demyelinating Disorders of Central Nervous System: A Retrospective Indian Tertiary Care Hospital Cohort
Authors: Prithviraj Ramakrishna , Banerjee Bidisha , Acharya Ullas V. , Hafis Muhammed , Sashidharan Sruthi 
Published: April 2024

Abstract
Background Pediatric acquired demyelinating syndrome (ADS) constitutes a group of treatable disorders with acute neurologic dysfunction. Neuroimaging has played a significant role in diagnosis of ADS. We describe clinico-radiologic spectrum, outcomes, and comparison of the groups: acute disseminated encephalomyelitis (ADEM), neuromyelitis optica spectrum disorder (NMOSD), clinically isolated syndrome (CIS), multiple sclerosis (MS), and myelin oligodendrocyte glycoprotein antibody-associated disorders (MOGAD).
Methods Retrospective review of 70 children with ADS at a tertiary care hospital over 15 years (2008–2023) was performed. Diagnosis was assigned as per International Pediatric Multiple Sclerosis Study Group criteria 2016. Fisher's exact and chi-square tests were applied.
Results Thirty-nine boys and 31 girls aged 8.2 ± 4.0 years with CIS (n = 27), ADEM (n = 16), NMOSD (n = 13), MS (n = 1), and MOGAD (n = 13) were included. Clinical syndromes with positive significant association included polyfocal symptoms, encephalopathy in ADEM, optic neuritis (ON) in MOGAD, brainstem, area postrema syndrome in NMOSD. MOGAD presented with atypical presentations like prolonged fever (PF; 76.9%) and aseptic meningitis (23%). Seropositivity for myelin oligodendrocyte glycoprotein immunoglobulin-G was 62% and for NMO-IgG 2.6%. Neuroimaging of MOGAD showed lesions predominantly in basal ganglia/thalami (69.2%), optic nerve (46.2%), and cerebellum (46.2%). Imaging patterns between ADEM and MOGAD were comparable except for more ON (p = 0.004), spinal cord (p = 0.01), and cerebellar lesions (p = 0.03) in MOGAD. Area postrema lesion was unique to NMOSD. All patients received immunotherapy, of whom 91.4% (n = 64) had good recovery, 8.6% (n = 6) had functional limitation on modified Rankin scale at discharge, and 12 (17.1%) relapsed.
Conclusion The largest group was CIS. Seropositivity of MOG was high with atypical presentations like PF and aseptic meningitis. Specific neuroimaging patterns correlated with ADS categories. Short-term outcome with immunotherapy was favorable in spite of relapses.
Migrated Peripherally Inserted Central Catheter in the Right Ventricle and Bilateral Pulmonary Arteries: A Case Report
Authors: Anand Reena , Dagar Vineeta , Aggarwal Rajeev , Batra Sandeep 
Published: April 2024

Abstract
Introduction Central venous catheterization is a common tool widely used in medical treatment for long-term intravenous administration of medication (e.g. chemotherapy or antibiotics) or parenteral nutrition. Here, we present a case of a missing peripherally inserted central catheter (PICC) which was detected on computed tomography (CT) scan thorax.
Case Report A 50-year-old female admitted for follow-up for adenocarcinoma rectum was found to have a missing PICC line and advised CT thorax for evaluation. The imaging findings revealed coiled PICC line in the right atrium extending to inferior vena cava and into right ventricle and further extending and coiled PICC is seen in the main, right, and left pulmonary arteries. Through emergency interventional procedure, the PICC line was successfully retrieved percutaneously via the right femoral vein.
Conclusion PICC fracture is less common and always seen without significant discomfort if not found timely, and it may lead to serious complications, such as pulmonary embolism, and even death. Early detection and removal may help to prevent signiﬁcant mortality.
Demystifying the Mystery of Genes: A Case Report on Constitutional Mismatch Repair Deficiency
Authors: Siju Jose , Sahu Arpita , Bhattacharya Kajari , Prasad Maya , Sarin Rajiv , Gupta Tejpal 
Published: April 2024

AbstractConstitutional mismatch repair deficiency (CMMRD) is a rare childhood cancer predisposition syndrome that results from biallelic germline mutations in one of the four MMR genes, MLH1, MSH2, MSH6, or PMS2. This syndrome is characterized by a broad spectrum of early-onset malignancies, including hematologic malignancies, colorectal malignancies, brain tumors, and other malignancies. It is common to have more than one malignancy in an individual diagnosed with CMMRD. In addition to malignancies, primary immunodeficiency in the form of low or absent immunoglobulin levels can also be seen in CMMRD. Congenital abnormalities such as agenesis of the corpus callosum (ACC), cavernous hemangioma, and other non-neoplastic diseases can also be linked to it. In this case report, we discussed the case of a girl born out of consanguineous marriage initially identified as having T-cell acute lymphoblastic lymphoma and later found to have selective immunoglobulin A (IgA) deficiency. Her younger sibling with a pontine cavernous hemangioma was also diagnosed with lymphoma. The girl exhibited brain lesions on magnetic resonance imaging (MRI), which were initially diagnosed as posterior reversible encephalopathy syndrome (PRES) related changes; however, one of the lesions persisted and remained stable over a period of 2 years and more in favor of diffuse glioma. The younger sibling also showed a solitary lesion in the brain. Based on the clinical and radiological findings, a diagnosis of CMMRD was suspected. Next-generation sequence (NGS) analysis of her blood sample was done. The results showed a homozygous mutation in the MSH6 gene was diagnostic of CMMRD.
Bilobed Prepontine White Epidermoid Cyst Camouflaged as Tubercular Abscess: A Case Report
Authors: Gala Foram , Madhariya Vaishali 
Published: April 2024

AbstractEpidermoid cysts are ectodermally derived benign extra-axial lesions that have typical imaging characteristics following cerebrospinal fluid (CSF) signal intensity, but occasionally show unusual hyperintensity on T1-weighted images (T1WI), known as white epidermoid, thus posing a diagnostic challenge. We report an unusual case of bilobed prepontine white epidermoid masquerading as tuberculous abscess in a known case of tubercular meningitis.
Ultrasound Differentiation of Twins with Discordant Congenital Diaphragmatic Hernia in the Delivery Room
Authors: Cullen Sean Michael , Kasdorf Ericalyn , Cohen Sara , Kovanlikaya Arzu , Roser Brittany , Oxford-Horrey Corrina , Perez Cynthia , Chang Catherine 
Published: April 2024

AbstractMost infants with prenatally diagnosed congenital diaphragmatic hernia (CDH) are intubated rapidly after birth to optimize oxygenation and ventilation while avoiding abdominal distention and high mean airway pressures. A twin pregnancy complicated by one twin with a CDH diagnosis is a rare event and is associated with preterm delivery and low birth weight compared to singletons with CDH. In rare cases of discordant CDH in twin pregnancies with an absence of external distinguishing features (similar weights, fetal presentation, and sex), it may be difficult to quickly determine which twin has CDH in the delivery room (DR), raising ambiguity about the best management of both infants. This case describes the successful use of ultrasound (US) in the DR to rapidly diagnose the presence or absence of CDH in discordant twins. By developing a resuscitation algorithm and using in situ simulations prior to delivery, the twin with CDH was rapidly identified, intubated, and transported to the neonatal intensive care unit (NICU) for further management. The twin without CDH received routine care and was transferred to the well-baby nursery. Interprofessional planning and simulation may be used to design a safe resuscitation plan incorporating US diagnosis of diaphragmatic anomalies into the Neonatal Resuscitation Program (NRP) algorithm.
Nonfistulizing Perianal Crohn's Disease
Authors: Simon Emily , Steinhagen Emily 
Published: April 2024

AbstractPerianal Crohn's disease (CD) includes a wide range of nonfistulizing sequela, including fissures and ulcers, skin tags, anal stricture, and anal cancer. Symptoms related to perianal manifestations of CD are often disabling and have a significant impact on patients' quality of life. They include pain, drainage, bleeding, difficulty with hygiene and may cause secondary difficulties with sexual and defecatory dysfunction. The care of patients with perianal CD requires a thoughtful approach, including detailed history taking, physical examination, and often multidisciplinary care teams to maximize quality of life and ameliorate symptoms.
Deconstructing ESG scores: investing at the category score level
Authors: Ehlers Torsten , Elsenhuber Ulrike , Jegarasasingam Anandakumar , Jondeau Eric 
Published: April 2024

AbstractEnvironmental, social, and governance (ESG) scores are a key tool for asset managers in designing and implementing ESG investment strategies. They, however, amalgamate a broad range of fundamentally different factors, creating ambiguity for investors as to the underlying drivers of higher or lower ESG scores. We explore the feasibility and performance of more targeted investment strategies based on specific ESG categories by deconstructing ESG scores into their granular components. We implement “best-in-class” strategies by excluding firms with the lowest category scores and reinvesting the proceeds in firms with the highest scores, maintaining the same regional and sectoral composition. These approaches reduce the portfolio’s tracking error and slightly improve its risk-adjusted performance, while still yielding large gains in targeted ESG scores.