bluuebunny/crossref_metadata_2025_split huggingface dataset:
Engineering Agonistic Bispecifics to Investigate the Influence of Distance on Surface-Mediated Complement Activation
Authors: Hamers Sebastiaan M W R , Boyle Aimee L , Sharp Thomas H 
Published: May 2024

Abstract
The development of agonists capable of activating the human complement system by binding to the C1 complex presents a novel approach for targeted cell killing. Bispecific nanobodies and Abs can successfully use C1 for this purpose; however, efficacy varies significantly between epitopes, Ab type, and bispecific design. To address this variability, we investigated monomeric agonists of C1 in the form of bispecific nanobodies, which lack Fc domains that lead to oligomerization in Abs. These therefore offer an ideal opportunity to explore the geometric parameters crucial for C1 activation. In this study, we explored the impact of linker length as a metric for Ag and epitope location. DNA nanotechnology and protein engineering allowed us to design linkers with controlled lengths and flexibilities, revealing a critical range of end-to-end distances for optimal complement activation. We discovered that differences in complement activation were not caused by differential C1 activation or subsequent cleavage of C4, but instead impacted C4b deposition and downstream membrane lysis. Considering the importance of Ab class and subclass, this study provides insights into the structural requirements of C1 binding and activation, highlighting linker and hinge engineering as a potential strategy to enhance potency over specific cellular targets. Additionally, using DNA nanotechnology to modify geometric parameters demonstrated the potential for synthetic biology in complement activation. Overall, this research offers valuable insights into the design and optimization of agonists for targeted cell killing through complement activation.
Estimating the Contribution of Various Construction Materials on Construction Waste Generation Onsite in South Eastern Nigeria
Authors: Onyia M. E. , Aroh C. U. 
Published: May 2024

There are many challenges arising from the generation of construction waste onsite, chief of them are environmental pollution and material loss. A number of factors can lead to the generation of construction waste. Hence, the objective of this paper was to ascertain the construction material that leads greatest onsite generation of construction waste in Nigeria using structured questionnaire to gather data from primary source by surveying fourteen most common construction materials. Results obtained revealed that timber, ceramic tiles and mortar ranked 1st , 2nd and 3rd with standard deviation of 1.14, 1.156 and 1.265; while roofing sheets, PVC water pipes and paint contributed the least 12th, 13th and 14th with a standard deviation of 1.115, 1.222 and 1.095 respectively.
Transgressive Knowing
Authors: Koenig Oliver , Seneque Megan , Akomolafe Bayo , Fazey Ioan , McGarry Dylan , Kulundu-Bolus Injairu , McKenzie Fiona , Proyer Michelle 
Published: May 2024

This issue's In-Dialogue represents the intentional epitomization of many conversations the Editorial Team has been having since JASC’s inception around what we mean by 'transformative'. As convenors of the dialogue Oliver Koenig and Megan Seneque invited a small group of individuals who, in their ongoing work, have been deeply immersed in exploring research and praxis paradigms that respond ethically, critically, and creatively to the intersecting crises of our time. Together, the group set out to explore the integrity of 'research' and 'practice', their critical entanglement and co-dependence, and the nature of practices that enable worlds to be created in certain ways. Rather than attempting to arrive at a consensual understanding, the dialogue that unfolds can be seen as a mirror of the world-making practice(s) that are characteristic of transformative research
Writing from a Relational Systems Thinking Standpoint
Authors: Goodchild Melanie 
Published: May 2024

Dr. Melanie Goodchild (Anishinaabe, moose clan) shares story about the complexities of academic writings that engage with Indigenous ancestral wisdom traditions and thinking patterns. The commentary offers considerations for co-authoring papers and citing Indigenous authors from a place of deep engagement and relationship. This is a humble offering on how to write from a Relational Systems Thinking (Goodchild, 2021) standpoint.
Pengaruh Organisasi Politik Islam Indonesia Terhadap Kesedaran Nasionalisme Melayu (1930-1959)
Authors: Md Bahrudin Mohd Zul Fahmi 
Published: May 2024

Perbincangan mengenai pengaruh Indonesia terhadap kesedaran nasionalisme Melayu di Tanah Melayu yang khusus melibatkan kelompok Islamis atau kelompok agama tidak diketengahkan dengan mendalam seperti mana pengaruh dari kelompok kiri, komunis ataupun sosialis. Kajian ini meneliti pengaruh Indonesia terhadap perkembangan nasionalisme di Tanah Melayu dengan menumpukan kepada pengaruh Indonesia dalam bentuk organisasi politik Islam terhadap perkembangan nasionalisme di Tanah Melayu bermula tahun 1930an sehingga tahun 1950an. Kajian ini mendapati pertalian yang rapat antara kelompok agama di Indonesia dan Tanah Melayu serta peranan penting institusi pendidikan agama boleh menjadi faktor penyumbang kepada pengaruh Indonesia yang kuat dalam mengesani perkembangan nasionalisme di Tanah Melayu sekitar tahun 1930an sehingga tahun 1950an. Penulisan ini boleh menjadi sebahagian dari permulaan untuk memahami pergerakan nasionalisme di Tanah Melayu dengan lebih mendalam, khususnya dalam kalangan Islamis atau kelompok agama.

The discussion regarding Indonesia's influence on Malay nationalism awakening in Malaya, specifically involving Islamist or religious groups, has not been highlighted as well as the influence from leftist, communist, or socialist groups. This study examines Indonesia's influence on the development of nationalism in Malaya by focusing on the influence of Indonesia through its Islamic political organizations on the progress of nationalism in Malaya from the 1930s to the 1950s. The study finds that the close relationship between religious groups in Indonesia and Malaya, as well as the important role of religious educational institutions, can be the contributing factors to Indonesia's strong influence on the development of nationalism in Malaya during the 1930s to the 1950s. This writing can be a part of the starting point to understand the nationalist movement in Malaya more deeply, particularly among Islamists or religious groups.
Внутренняя миграция в Казахстане: правовые и социальные аспекты
Authors: Амерханова И.К. 
Published: May 2024

В данной статье рассмотрены внутренние миграционные процессы в Республике Казахстан, определены основные аспекты влияния миграции на процессы общественной жизни, обозначены принципы политики государства в области миграции. В статье рассмотрены проблемы внутренней миграции в Казахстане.
Мақалада Қазақстан Республикасындағы ішкі көші-қон процестері қарастырылып, көші-қонның қоғамдық өмір процестеріне әсер етуінің негізгі аспектілері анықталған, көші-қон саласындағы мемлекеттік саясаттың принциптері көрсетілген. Мақалада Қазақстандағы ішкі көші-қон проблемалары қарастырылған.
Профессиональная самоподготовка будущих специалистов
Authors: Зиядина С.Т. , Султанова Н.К. 
Published: May 2024

Мақалада студенттердің болашақ кәсіби қызметінің сыртқы белгілері, бейімділіктері қабілеттері, сонымен бірге болашақ кәсіби өзін-өзі анықтаудың рөлінің маңызы баяндалады. Ғалым психолог, педагогтардың зерттеулерінде негіз болатын оқушының түсінігіндегі идеялардың эмпатиялық көріністерінің өзін-өзі кәсіби анықтау теориясының өзекті мәселесі қарастырылды. ЖОО–ғы педагогикалық ұжымның кезеңдерін, басты бағыттарын айқындалды. Маман ретінде өзін-өзі анықтауды бекіту іс-әрекетінің бағыттары талданып, талқыланды. Бұнда қарастырылып отырған өзін - өзі анықтау және өзін-өзі жетілдіру процесіндегі проблема, өзінің кәсіби қызығушылығы, қабілеттері мен жас мамандар үшін қажеттілігі мен оның құрылымдары, факторлары.
В статье освещаются внешние признаки, склонности и способности будущей профессиональной деятельности студентов, а также значение роли будущего профессионального самоопределения. Рассмотрена актуальная проблема теории профессионального самоопределения эмпатических проявлений идей в понимании учащегося, которая лежит в основе исследований ученого психолога, педагога. Определены этапы, основные направления деятельности педагогического коллектива вуза. Проанализированы и обсуждены направления деятельности по закреплению самоопределения как специалиста. Проблема рассматриваемого здесь процесса самоопределения и самосовершенствования, его профессиональных интересов, способностей и потребностей для молодых специалистов, его структур, факторов.
The article highlights the external signs, inclinations and abilities of future professional activity of students, as well as the importance of the role of future professional self-determination. The article deals with the actual problem of the theory of professional self-determination of empathic manifestations of ideas in the understanding of the student, which is the basis of the research of the scientist psychologist, teacher. The stages and main directions of the activity of the pedagogical staff of the university are determined. The directions of activity on consolidation of self-determination as a specialist are analyzed and discussed. The problem of the process of self-determination and self-improvement considered here, its professional interests, abilities and needs for young professionals, its structures, factors.
Beyond Bullets and Bombs
Authors: Kuriansky Judy 
Published: May 2024

In the midst of ongoing Israeli-Palestinian conflict, civil war, and political discord, courageous civilians from both sides are working together toward mutual understanding and peace. In 40 captivating chapters, experts tell intriguing personal stories, interwoven with psychosocial models and principles, describing how people living in hostile cultures can establish harmony. We come to know established programs like Seeds of Peace and Search for Common Ground, as well as lesser-heralded, yet valiant efforts by children and adults of the region. This hope-filled work will be of interest to everyone who cares about peace, as well as to professionals and students in the social sciences, psychology, international relations, public policy, human rights, and cross-cultural studies.
In the midst of ongoing Israeli-Palestinian conflict, civil war, and political discord, courageous civilians from both sides are working together toward mutual understanding and peace. Israeli Jews and Arabs, and Palestinian Muslims and Christians, young and old, men and women, are cooperating in grassroots people-to-people projects, developing educational programs and creating activities to bridge their differences.Beyond Bullets and Bombsshowcases such impressive and important projects that deserve more support and world attention. In 40 captivating chapters, experts tell intriguing personal stories interwoven with psychosocial models and principles proving how people living in hostile cultures can establish peace.
This collection is the perfect companion to Kuriansky's earlier book,Terror in the Holy Land: Inside the Anguish of the Israeli-Palestinian Conflict, an unprecedented work that presents more than 30 chapters written by Israelis, Palestinians, and psychological experts on the underpinnings and effects of the conflict. In the volume at hand, we come to know established programs like Seeds of Peace and Search for Common Ground, as well as lesser-heralded, yet valiant efforts by children and adults of the region working together for peace. Both volumes will be of interest to everyone who cares about peace, as well as to professionals and students in the social sciences, psychology, international relations, public policy, human rights, and cross-cultural studies.
The Cultivation of Body and Mind in Nineteenth-Century American Delsartism
Authors: Ruyter Nancy 
Published: May 2024

This study chronicles the American adaptation of the theory and practice of the French acting, singing, and aesthetics teacher, Francois Delsarte. Delsartism was introduced in the United States by Steele Mackaye, Delsarte's only American student. American Delsartism, with its emphasis on physical culture and expression, differed significantly from Delsarte's works in France. The system evolved from professional training for actors and orators to a means of physical culture and expression that became popular among middle and upper class American women and girls. It allowed nineteenth-century women to pay attention to their bodies, to explore their own physicality, and to perform in a socially acceptable venues. In its later manifestations, Delsartism influenced the innovative dance of such artists as Isadora Duncan, Ruth St. Denis, and Ted Shawn. Biographical information on the most notable figures in the development of American Delsartism is presented along with a discussion of the spread of Delsartism throughout the United States and to Germany. The Delsartean approach to training and expression is traced from Delsarte and Mackaye through the theory, teaching, and performance of Genevieve Stebbins, the most notable American proponent of the system.
This work will appeal to scholars of dance history and of late nineteenth-century women's studies. Theater historians will appreciate the detailed account of the system as developed and taught by Steele Mackaye as training for actors. Although Delsartism has been acknowledged as relevant to the history of modern dance, scant information and research has previously been published which explores the movement in depth and discusses its importance to women's physical and cultural education in nineteenth-century America. Photographs illustrate the text and an extensive bibliography serves as a useful guide for further research.
Family Ties in Victorian England
Authors: Nelson Claudia 
Published: May 2024

The Victorians were passionate about family. While Queen Victoria's supporters argued that her intense commitment to her private life made her the more fit to mother her people, her critics charged that it distracted her from her public responsibilities. Here, Nelson focuses particularly on the conflicting and powerful images of family life that Victorians produced in their fiction and nonfiction—that is, on how the Victorians themselves conceived of family, which continues both to influence and to help explain visions of family today.
Drawing upon a wide variety of 19th-century fiction and nonfiction, Nelson examines the English Victorian family both as it was imagined and as it was experienced. For many Victorians, family was exalted to the status of secular religion, endowed with the power of fighting the contamination of unchecked commercialism or sexuality and holding out the promise of reforming humankind. Although in practice this ideal might have proven unattainable, the many detailed 19th-century descriptions of the outlook and behavior appropriate to fathers and mothers, sons and daughters, and other family members illustrate the extent of the pressure felt by members of this society to try to live up to the expectations of their culture. Defining family to include the extended family, the foster or adoptive family, and the stepfamily, Nelson considers different roles within the Victorian household in order to gauge the ambivalence and the social anxieties surrounding them—many of which continue to influence our notions of family today.
Food in the United States, 1820s-1890
Authors: Williams Susan 
Published: May 2024

The period from the 1820s to 1890 was one of invention, new trends, and growth in the American food culture. Inventions included the potato chip and Coca-Cola. Patents were taken out for the tin can, canning jars, and condensed milk. Vegetarianism was promulgated. Factories and mills such as Pillsbury came into being, as did Quaker Oats and other icons of American food. This volume describes the beginnings of many familiar mainstays of our daily life and consumer culture. It chronicles the shift from farming to agribusiness. Cookbooks proliferated and readers will trace the modernization of cooking, from the hearth to the stove, and the availability of refrigeration. Regional foodways are covered, as are how various classes ate at home or away. A final chapter covers the diet fads, which were similar to those being touted today.
The period from the 1820s to 1890 was one of invention, new trends, and growth in the American food culture. Inventions included the potato chip and Coca-Cola. Patents were taken out for the tin can, canning jars, and condensed milk. Vegetarianism was promulgated. Factories and mills such as Pillsbury came into being. This volume describes the beginnings of many familiar mainstays of our daily life and consumer culture. It chronicles the shift from farming to agribusiness. Cookbooks proliferated and readers will trace the modernization of cooking, from the hearth to the stove, and the availability of refrigeration. Regional foodways are covered, as are how various classes ate at home or away. A final chapter covers the diet fads, which were similar to those being touted today.
The volume is targeted toward high school students on up to the general public who want to complement U.S. history cultural studies or better understand the fascinating groundwork for the modern kitchen, cook, and food industry. Abundant insight into the daily life of women is given. Period illustrations and recipes and a chronology round out the text.
Кыргыз республикасында жогорку квалификациялуу кадырларды даярдоодо педиатрия кафедралардын орду
Authors: Кудаяров Д.К. 
Published: May 2024

В статье представлены данные о первых годах организации кафедры детских болезней при Киргизском государственном медицинском институте и дальнейшем расширении педиатрических кафедр, обосновываются положительная роль кафедр в подготовке врачей педиатров и научных работников, в снижении детской заболеваемости т смертности в Кыргызстане.
The article presents data on the first years of the organization of the Department of Children's Diseases at the Kyrgyz State Medical Institute and the further expansion of pediatric departments, substantiates the positive role of the departments in the training of pediatricians and scientists, in reducing child morbidity and mortality in Kyrgyzstan.
Макалада Кыргыз мамлекеттик медицина институтунда балдардын оорулары кафедрасын уюштуруунун алгачкы жылдарындагы жана педиатриялык кафедраларды андан ары кеңейтүү жөнүндө маалыматтар келтирилип, КР балдардын ооруларын жана өлүмүн азайтууда педиатрларды жана окумуштууларды даярдоодо кафедралардын позитивдүү ролу негизделет.
The Effect of Promotion Through Social Media TikTok on Interest in Staying at Pangeran Beach Hotel Padang
Authors: Afdhal Zikri Muhammad 
Published: May 2024

Technological progress and breakthroughs are evident across various facets of human existence, with the swift development of the internet captivating global attention and integrating seamlessly into the fabric of modern daily life. and as many as 160 million people use social media this is the basis for a promising market for social media industry players, such as the tik tok application. The Tik Tok application in the 2023 year is the 1 of 4 most used social media platform in Indonesia, because people in Indonesia must know this application and some become its users. TikTok users range from children, adolescents, to adults. The purpose of this study was to examine the effect of promotion through social media TikTok on interest in staying at Pangeran Beach Hotel Padang. The study used a quantitative with a causal associative approach. The data was obtained by distributing questionnaires online through TikTok users who follow akun TikTok Pangeran Beach Hotel Padang. So that as many as 240 people were obtained, with a Likert scale. The data analysis technique used the Partial Least Square Structural Equation Modeling. The results found promotion through social media influenced TikTok account user intereset in Staying at Pangeran Beach Hotel Padang. This study concluded that when promoting using TikTok social media with clear and easy to understand context and meaning, customers increase their desire to stay at that place.
Ensino de Língua Inglesa para Alunos com Deficiência Intelectual: Um estudo bibliográfico
Authors: Roberta Coracim Nathály , Freitas Ana Paula de 
Published: May 2024

Este estudo teve como objetivo geral investigar como tem ocorrido o ensino de língua inglesa para crianças com deficiência intelectual. Especificamente, a investigação visou: 1) identificar os desafios no ensino de língua inglesa a alunos com deficiência intelectual; 2) conhecer as dificuldades dos professores ao atuar no ensino dessas crianças dentro da sala de aula e durante sua própria formação, e 3) reconhecer como o tema do ensino de línguas para crianças com deficiência tem sido abordado nos cursos de licenciatura em Letras. A metodologia se fundamentou em uma pesquisa qualitativa de cunho bibliográfico. Os bancos de pesquisa consultados foram: banco de dados do Portal de Periódicos da Capes, Google Acadêmico e Scielo.Em consonância com a teoria histórico-cultural, as análises, de cunho explicativo, indicaram que são muitos os desafios para ensinar a língua inglesa para alunos com deficiência, tais como, a busca pelas estratégias e recursos para promover uma aprendizagem que seja significativa para esses alunos e a pouca experiência docente com esse público. O baixo número de pesquisas encontradas nos faz questionar se o tema é de interesse dos pesquisadores ou se crianças com deficiência intelectual não têm tido acesso à língua inglesa, o que geraria poucos estudos com essa abordagem. Os estudos analisados permitem reflexões sobre a busca de caminhos de aprendizagem para todos os alunos, o que implica em políticas públicas efetivas em prol de uma educação verdadeiramente inclusiva.
Exploratory study of nocebo effect in senior medical students
Authors: Pischos Charalampos , Politis Antonios , Sfikakis Petros , Papageorgiou Charalampos 
Published: May 2024

Background Νocebo Effect is known to induce adverse symptoms after negative expectations which can be manifested on a physical and psychological level. As 6th year medical students often face a wide range of clinical challenges and may be prone to negative expectations or beliefs affecting their pre-clinical and clinical success, we want to investigate how they are affected by the Nocebo Effect. Objective To investigate whether a nocebo effect can be induced when exposing final-year students to the clinical context of their training. Methods We used verbal suggestions as a nocebo mechanism and by using three tools, the Illness Attitude Scales, the Symptom Checklist-90, and the State-Trait Anxiety Inventory, we examined the difference in scores on measures of psychometric parameters in 33 participants who were on their 6th year medical and attended three clinics for the first time during their education. The administrations were given before and after attending each clinic, and negative verbal suggestions were given prior to the first administration. We also measured whether the overall number of clinics, had an effect on psychometric parameters. Results The results revealed a significant increase in second administration overall in the three clinics in specific psychometric parameters but no statistically significant difference was observed after attending consecutive clinics. Conclusion Students reported the occurrence of adverse symptoms in the investigated psychometric parameters, which should be noted in order to avoid potential educational clinical failure.