bluuebunny/crossref_metadata_2025_split huggingface dataset:
Assessment of p53 functional activity in tumor cells and histologically normal mucosa from patients with head and neck squamous cell carcinoma
Authors: Van der Vorst Sébastien , Dekairelle Anne–France , Weynand Birgit , Hamoir Marc , Gala Jean–Luc 
Published: November 2011

AbstractBackgroundThe purpose of this study was to investigate the value of p53 functional analysis of separated alleles in yeast (FASAY) as a witness of p53/p21 pathway alteration in head and neck squamous cell carcinoma (HNSCC).MethodsThe p53 transcriptional activity was prospectively analyzed in 82 newly diagnosed patients with HNSCC. FASAY and p53 immunostaining were carried out on paired tumoral and histologically normal tissues. The predictive value of FASAY for locoregional recurrence was assessed by Cox survival analysis.ResultsLoss of p53/p21 transcriptional activity was encountered in 88% tumoral and 18% histologically normal samples, associated with mutations (79%) and insertions/deletions (21%). The p53 overexpression underestimated p53 transcriptional abnormalities. FASAY‐positive histologically normal mucosa was significantly associated with locoregional recurrence.ConclusionFASAY positivity indicates field cancerization in a subgroup of patients with HNSCC, in which nonfunctional p53 was significantly associated with locoregional recurrence. This prompted us to pursue the study on the p53 functional status of normal mucosa in patients with HNSCC. © 2011 Wiley Periodicals, Inc. Head Neck, 2011
Ultrasound‐guided botulinum toxin injection: A simple in‐office technique to improve tracheoesophageal speech in postlaryngectomy patients
Authors: Chaukar Devendra A. , Sayed Suhail I. , Shetty Nitin S. , Kulkarni Aniruddha V. , Kulkarni Suyash S. , Deshmukh Anuja D. , D'Cruz Anil K. 
Published: November 2011

AbstractBackgroundPharyngoesophageal spasm is a known entity to cause hypertonic/failed tracheoesophageal speech and is successfully treated by botulinum toxin A injection. However, success of botulinum toxin treatment is based on the accurate localization of the pharyngoesophageal segment.MethodsA 65‐year‐old man who had a laryngectomy using voice prosthesis with hypertonic speech underwent ultrasonographic localization of the hypertonic pharyngoesophageal segment. The ultrasound findings were confirmed using videofluoroscopy. Under ultrasound guidance, botulinum toxin was injected into the hypertonic pharyngoesophageal segment and subsequently voice outcomes were evaluated by a speech language pathologist and the pharyngoesophageal segment was assessed by using an ultrasound scan.ResultsThe patient had improvement in his postinjection tracheoesophageal puncture speech. Ultrasound scan assessment of the pharyngoesophageal segment showed adequate dilation as compared to the pre–botulinum toxin injection treatment.ConclusionUltrasonographic localization of the hypertonic pharyngoesophageal segment and ultrasound‐guided botulinum toxin injection is a simple, quick, and relatively cheap method to be used in routine practice. © 2011 Wiley Periodicals, Inc. Head Neck, 2013
Predictors of outcome in patients with metastatic cutaneous head and neck squamous cell carcinoma involving cervical lymph nodes: Improved survival with the addition of adjuvant radiotherapy
Authors: Wang Jeffrey T. , Palme Carsten E. , Morgan Gary J. , Gebski Val , Wang Allen Y. , Veness Michael J. 
Published: November 2011

AbstractBackgroundThe purpose of this study was to compare the outcome of surgery against surgery plus radiotherapy in patients with metastatic cutaneous head and neck squamous cell carcinoma (HNSCC) to cervical nodes.MethodsWe conducted a 28‐year retrospective analysis of 122 patients whom were treated for metastatic cutaneous HNSCC involving the cervical nodes (levels I–V).ResultsAfter surgery alone, 11 patients (55%) developed recurrence compared with 23 patients (23%) after surgery plus radiotherapy. On multivariate analysis, the following variables were significantly associated with disease‐free survival (DFS): immunosuppression (p = .002), treatment modality (p < .001), extracapsular spread (p = .009), and pathological nodal stage (p = .04). Patients undergoing surgery plus radiotherapy had a significantly better 5‐year DFS (74% vs 34%; p = .001) and 5‐year overall survival (OS; 66% vs 27%; p = .003) compared with surgery alone.ConclusionIn patients with metastatic cutaneous HNSCC involving cervical nodes, survival was significantly improved with the addition of radiotherapy. © 2011 Wiley Periodicals, Inc. Head Neck, 2011
Quantitative histological-hemodynamic correlations in cirrhosis
Authors: Sethasine Supatsri , Jain Dhanpat , Groszmann Roberto J. , Garcia-Tsao Guadalupe 
Published: November 2011

Abstract

We have previously shown, in a semiquantitative analysis of liver biopsies showing cirrhosis, that thickness of fibrous septa separating cirrhotic nodules and small size of cirrhotic nodules correlated independently with portal pressure (as determined by the hepatic venous pressure gradient; HVPG) and were independent predictors of the presence of clinically significant portal hypertension (PH). This study aimed to confirm these results using quantitative analysis of these biopsies using digital image analysis. Biopsies of 42 patients with cirrhosis and HVPG measurements within 6 months of the biopsy were included in the study. The following parameters were scored quantitatively and without knowledge of HVPG results: total fibrosis area, septal thickness, nodule size, and number of nodules per millimeter of length of liver biopsy. Fibrosis area was the only parameter that independently correlated with HVPG (r = 0.606; P < 0.0001). Correlation was significant, even among patients with clinically significant PH (r = 0.636; P < 0.005). Fibrosis area and nodule size were both independently predictive of the presence of clinically significant PH (r = 0.57; P = 0.003). Conclusions: On quantitative analysis, fibrosis area was the parameter that correlated best with HVPG and the presence of clinically significant PH. Beyond pathophysiological implications, this also has methodological implications that are discussed in this article. (Hepatology 2012)
A framework for the human resources role in managing culture in mergers and acquisitions
Authors: Marks Mitchell Lee , Mirvis Philip H. 
Published: November 2011

AbstractScholars, business people, and change agents agree that culture matters in eventual merger and acquisition (M&A) success. Researchers have generated many insights and practitioners have developed many interventions regarding culture in M&A. Managing culture, however, is often a low priority when executives are consumed with the deal's financial and strategic aspects. The authors propose a framework for how Human Resources (HR) can work with business partners in managing acculturation in M&A. They first examine the relationship between cultural differences and M&A outcomes, how culture manifests itself in combinations, and the causes and stages of culture clash. They then highlight the value of a clear “cultural endstate” in M&A and apply classic change management theory to identify actions that unfreeze current cultural mind‐sets, move people toward the desired endstate, and refreeze the desired culture. Their framework specifies HR actions for four distinct cultural endstates—pluralism (in which the partner companies coexist), integration (in which the partners blend current cultures together), assimilation (in which one company absorbs the other), and transformation (in which the partner companies abandon key elements of their current cultures and adopt new values and norms). © 2011 Wiley Periodicals, Inc.
A spatially and temporally explicit risk assessment for salmon from a prey base exposed to agricultural insecticides
Authors: Poletika Nicholas N , Teply Mark , Dominguez Lawrence G , Cramer Steven P , Schocken Mark J , Habig Clifford , Kern Matthew , Ochoa-Acuña Hugo , Mitchell Gary C 
Published: November 2011

Abstract
This risk assessment applied a framework for determining probable co-occurrence of juvenile spring Chinook salmon (Oncorhynchus tshawytscha) with agricultural pesticides in the Willamette Basin, Oregon (Teply et al. this issue2012) to characterize risk to the threatened population. The assessment accounted for spatial and temporal distribution of 6 acetylcholinesterase-inhibiting insecticides in salmonid habitat within the basin and their relative contributions to mixture toxicity estimated from chemical monitoring data. The 6 insecticides were chlorpyrifos, diazinon, malathion, carbaryl, carbofuran, and methomyl. Seasonal distributions of the juvenile salmon prey base across the basin were determined and compared to co-occurrence with the insecticide mixture to determine the probability of prey reduction and reduced production of juvenile fish. Probability of effect on freshwater aquatic invertebrates was based on acute toxicity species sensitivity distributions (normalized to the most potent compound, chlorpyrifos) using a novel approach to apply the toxicological concept of concentration addition to species sensitivity distributions with differing slopes. The chlorpyrifos distribution was then used to determine relative sensitivity among various species tested within the important taxa making up the prey base. A prey base index was devised, incorporating diet composition and prey availability, to evaluate the indirect effects of the insecticide mixture on juvenile salmon production occurring as a result of a reduction in the prey base. Our analysis targeted fish use of backwater and off-channel habitat units, because they generally coincide with agricultural lands in lowlands and represent shallow habitat with limited water exchange. The percentage of agricultural land use within 300 m of critical habitat stream reaches was used to scale chemical measurement data from a site with high agricultural land use across the full extent of the basin to provide estimates of chemical exposure in each reach. Seasonal impacts were evaluated from mean monthly concentrations. Stressor impact on 5 key taxa was evaluated at each time step and for each reach, and the outcome was compared to a conservation threshold assigned to the prey base index. Only 13% of juveniles reared in backwater, off-channel habitat within 300 m of agricultural land. Percent reduction of carrying capacity as a consequence of reduced prey was estimated to be 5% over the entire brood year. This can be considered lost capacity that is probably compensated elsewhere via increased occupancy (emigration to other habitat units within the reach), which is not accounted for in the model. Integr Environ Assess Manag 2012; 8: 285–300. © 2011 SETAC
PI3K/Akt‐dependent functions of TFII‐I transcription factors in mouse embryonic stem cells
Authors: Chimge Nyam‐Osor , Makeyev Aleksandr V. , Waigel Sabine J. , Enkhmandakh Badam , Bayarsaihan Dashzeveg 
Published: November 2011

AbstractActivation of PI3K/Akt signaling is sufficient to maintain the pluripotency of mouse embryonic stem cells (mESC) and results in down‐regulation of Gtf2i and Gtf2ird1 encoding TFII‐I family transcription factors. To investigate how these genes might be involved in the process of embryonic stem cell differentiation, we performed expression microarray profiling of mESC upon inhibition of PI3K by LY294002. This analysis revealed significant alterations in expression of genes for specific subsets of chromatin‐modifying enzymes. Surprisingly, genome‐wide promoter ChIP‐chip mapping indicated that the majority of differently expressed genes could be direct targets of TFII‐I regulation. The data support the hypothesis that upregulation of TFII‐I factors leads to activation of a specific group of developmental genes during mESC differentiation. J. Cell. Biochem. 113: 1122–1131, 2012. © 2011 Wiley Periodicals, Inc.
Zinc chloride‐catalyzed one‐pot, three‐component synthesis of 5,8‐dihydro‐5,8‐dioxo‐4H‐chromene derivatives
Authors: Srinivas Vakiti , Rao Vedula Rajeswar 
Published: November 2011

AbstractAn efficient zinc chloride‐catalyzed one‐pot synthesis of 5,8‐dihydro‐5,8‐dioxo‐4H‐chromene derivatives have been achieved by the reaction of 2,5‐dihydroxy‐6‐undecyl‐1,4‐bezoquinone, cyanothioacetamide, and aromaticaldehyde, in EtOH at room temperature. The structures of the products were characterized by IR, 1H‐NMR, mass spectra, and elemental analyses. J. Heterocyclic Chem., (2011).
Ovarian structure and oogenesis of the oviparous goodeids Crenichthys baileyi (Gilbert, 1893) and Empetrichthys latos Miller, 1948 (teleostei, Cyprinodontiformes)
Authors: Carmen Uribe Mari , Grier Harry J. , Parenti Lynne R. 
Published: November 2011

AbstractThe cyprinodontiform family Goodeidae comprises two biogeographically disjunct subfamilies: the viviparous Goodeinae endemic to the Mexican Plateau, and the oviparous Empetrichthyinae, known only from relict taxa in Nevada and California. Ovarian characteristics of two oviparous species of goodeid, Crenichthys baileyi and Empetrichthys latos, studied using museum collections, are compared with those of viviparous species of goodeids. Both subfamilies have a single, cystovarian ovary. The ovary in the viviparous Goodeinae has an internal septum that divides the ovarian lumen into two compartments, and it may possess oogonia. There is no ovarian septum in the oviparous C. baileyi and E. latos. Oogenesis is similar in both subfamilies with regard to the proliferation of oogonia, initiation of meiosis, primary growth and development of an oocyte during secondary growth in which fluid yolk progressively fuses into a single globule. Notably, eggs of C. baileyi and E. latos are approximately double the size of those of the viviparous Goodeinae in which embryos develop inside the ovarian lumen and are nourished, in part, by nutrients transferred from the maternal tissues, a mode of embryo development called matrotrophy. Egg envelopes of the two subfamilies differ in that those of C. baileyi and E. latos have a relatively thick zona pellucida, attachment fibrils or filaments that develop between the follicle cells during oogenesis, and a micropyle observed only in E. latos. In contrast, viviparous goodeid eggs have a relatively thin zona pellucida, but lack adhesive fibrils, and a micropyle was not observed. These reproductive characters are compared with those of species of the eastern North American Fundulus, a representative oviparous cyprinodontiform. One newlyrecognized shared, derived character, a single, median ovoid ovary with no obvious external evidence of fusion, supports monophyly of the Goodeidae. Differences among the goodeid subfamilies and Fundulus are interpreted relative to the oviparous versus viviparous modes of reproduction. J. Morphol., 2012. © 2011 Wiley Periodicals, Inc.
Opposite trends in summer precipitation in South and North Korea
Authors: Kim Yeonjoo , Kang B. , Adams J. M. 
Published: November 2011

AbstractWe analysed daily precipitation data at the rain gauge stations in North Korea over a period of 25 years from 1983 to 2007, and in South Korea over a period of 35 years from 1973 and 2007. We found a striking trend of decreasing summer precipitation across North Korea. By contrast, in South Korea, the trend is opposite: there is a major increase in summer precipitation. Also, the number of dry days in summer showed an increasing trend in North Korea and a decreasing trend in South Korea. For the number of days with heavy precipitation (i.e. days with above 50 mm/day daily precipitation) during summer, a decreasing trend was detected in North Korea, but no trend in South Korea. However, in South Korea, there was a significant increase of days with heavy precipitation over the whole year. These opposite trends in summer precipitation between North and South Korea were further confirmed using four global/regional satellite and rain gauge datasets of CPC Merged Analysis of Precipitation (CMAP), the Global Precipitation Climatology Project (GPCP), Precipitation REConstruction over the Land (PREC/L), and the Asian Precipitation‐Highly Resolved Observation Data Integration Towards the Evaluation of Water Resources (APHRODITE). Copyright © 2011 Royal Meteorological Society
Moisture transport into the Ethiopian highlands
Authors: Viste Ellen , Sorteberg Asgeir 
Published: November 2011

AbstractThe Ethiopian summer rains occur as air masses of various origins converge above the Ethiopian plateau. In this study, the relative importance of different moisture transport branches has been estimated using the Lagrangian trajectory model FLEXPART, and ERA‐Interim reanalysis data, to backtrack air reaching the northern Ethiopian highlands in July–August 1998–2008. The Indian Ocean, the Congo Basin and the Red Sea were found to be important moisture source regions; for air from the Indian Ocean aided by a considerable moisture uptake along routes across the African continent. The following main transport branches were identified: (1) Flow from the Gulf of Guinea, (2) Flow from the Indian Ocean, and (3) Flow from the north; from the Mediterranean region across the Red Sea and the Arabian Peninsula. The largest contribution to the moisture transport into, and release of moisture within, the northern Ethiopian highlands, was associated with air traveling from the Indian Ocean and from the north. This was partly due to the relatively high mean specific humidity of this air, and partly because a large proportion of the air that reaches the highlands, follows these routes. As a total, the amount of moisture brought into the highlands from the north is 46% higher than from the south, whereas the contribution to moisture release within the highlands is about equal for air coming from the south and from the north. While previous studies have emphasized the importance of the Gulf of Guinea, we find that despite the high specific humidity of the low‐level flow of air from the Gulf of Guinea, the amount of moisture carried into and released within the northern Ethiopian highlands through this branch, is much smaller than from the other branches—about 1/8 of that from the Indian Ocean. This is due to the fact that normally only a small proportion of the air reaching Ethiopia comes from the Gulf of Guinea. Copyright © 2011 Royal Meteorological Society
Structure of planar integral self‐affine tilings
Authors: Deng Da‐Wen , Jiang Tao , Ngai Sze‐Man 
Published: November 2011

AbstractFor a self‐affine tile in \documentclass{article}\usepackage{amssymb}\begin{document}\pagestyle{empty}$\mathbf {R}^2$\end{document} generated by an expanding matrix \documentclass{article}\usepackage{amssymb}\begin{document}\pagestyle{empty}$A\in M_2(\mathbf {Z})$\end{document} and an integral consecutive collinear digit set \documentclass{article}\usepackage{amssymb}\begin{document}\pagestyle{empty}${\mathcal D}$\end{document}, Leung and Lau [Trans. Amer. Math. Soc. 359, 3337–3355 (2007).] provided a necessary and sufficient algebraic condition for it to be disklike. They also characterized the neighborhood structure of all disklike tiles in terms of the algebraic data A and \documentclass{article}\usepackage{amssymb}\begin{document}\pagestyle{empty}${\mathcal D}$\end{document}. In this paper, we completely characterize the neighborhood structure of those non‐disklike tiles. While disklike tiles can only have either six or eight edge or vertex neighbors, non‐disklike tiles have much richer neighborhood structure. In particular, other than a finite set, a Cantor set, or a set containing a nontrivial continuum, neighbors can intersect in a union of a Cantor set and a countable set.
Effects of Electrostatic Interactions on the Translocation of Polymers Through a Narrow Pore Under Different Solvent Conditions: A Dissipative Particle Dynamics Simulation Study
Authors: Li Xuejin , Li Xiaolong , Deng Mingge , Liang Haojun 
Published: November 2011

AbstractPolymer translocation through a narrow pore is investigated using a particle‐based dissipative particle dynamics (DPD) method. A rigid core is included in each particle to avoid particle interpenetration problems based on the original DPD method. Electrostatic interactions of charged particles are simply represented via screened Coulombic interactions. The average translocation timeτversus polymer lengthNsatisfies the scaling lawτ∼Nβ. The scaling exponentβdepends on solvent quality. The results demonstrate that solvent quality exerts a considerable influence on the dynamics of translocation of polymers. The findings may help facilitate understanding of the dynamic behaviors of various polymer and DNA molecules during translocation processes.magnified image
k‐t ISD: Dynamic cardiac MR imaging using compressed sensing with iterative support detection
Authors: Liang Dong , DiBella Edward V. R. , Chen Rong‐Rong , Ying Leslie 
Published: November 2011

AbstractCompressed sensing (CS) has been used in dynamic cardiac MRI to reduce the data acquisition time. The sparseness of the dynamic image series in the spatial‐ and temporal‐frequency (x‐f) domain has been exploited in existing works. In this article, we propose a new k‐t iterative support detection (k‐t ISD) method to improve the CS reconstruction for dynamic cardiac MRI by incorporating additional information on the support of the dynamic image in x‐f space based on the theory of CS with partially known support. The proposed method uses an iterative procedure for alternating between image reconstruction and support detection in x‐f space. At each iteration, a truncated ℓ1 minimization is applied to obtain the reconstructed image in x‐f space using the support information from the previous iteration. Subsequently, by thresholding the reconstruction, we update the support information to be used in the next iteration. Experimental results demonstrate that the proposed k‐t ISD method improves the reconstruction quality of dynamic cardiac MRI over the basic CS method in which support information is not exploited. Magn Reson Med, 2012. © 2011 Wiley Periodicals, Inc.
Misuse of buprenorphine maintenance treatment since introduction of its generic forms: OPPIDUM survey
Authors: Nordmann Sandra , Frauger Elisabeth , Pauly Vanessa , Orléans Veronica , Pradel Vincent , Mallaret Michel , Thirion Xavier , Micallef Joëlle 
Published: November 2011

ABSTRACTPurposeThe purpose of the study was to compare, using data from Observation of Illicit Psychotropic Substances or Non‐medical Used Medications (OPPIDUM) surveys, first, the profile of buprenorphine users and their modalities of buprenorphine use from 2006 to 2008 and, second, two subgroups: brand‐name and generic buprenorphine users in 2008.MethodsOPPIDUM is an annual, nationwide, multicentric, cross‐sectional survey, including buprenorphine users followed in specialised centres dedicated to drug dependence. The evolution of the profile during three consecutive years (2006, 2007 and 2008) was analysed using Cochran‐Armitage test for trend. A multivariate regression analysis was used to identify the factors associated with the use of generic compared with brand‐name buprenorphine in 2008.ResultsIn OPPIDUM, 1311 individuals used buprenorphine in 2006, 1688 in 2007 and 1696 in 2008. The proportion of users of generic buprenorphine increased from 4.2% in 2006 to 31.7% in 2008. From 2006 to 2008, a decrease in intravenous use and higher than recommended dosage, with an increase in occupation, have been observed. According to the multivariate analysis, factors associated with being generic buprenorphine user compared with brand‐name buprenorphine user in 2008 were younger age, more education, absence of use of alcohol with buprenorphine, absence of heroin and/or cocaine use and absence of nasal route for buprenorphine.ConclusionThree years after the launch of the buprenorphine generic, the health professionals' and buprenorphine users' perception of generic can still change. Additionally, the long‐term impact of generic medications with abuse potential has not yet been studied. Thus, continued monitoring of buprenorphine is needed. Copyright © 2011 John Wiley & Sons, Ltd.