bluuebunny/crossref_metadata_2025_split huggingface dataset:
An investigation of the impact of atenolol on the risk of all-cause mortality in Asian individuals with hypertension and cardiovascular conditions
Authors: Alkattan Abdullah , Alsalameen Eman , Harmoush Alaa , Farawati Mhd Nour , Alsharif Hind , Mahmoud Nagla , Farawati Mhd Ali , Alfaleh Amjad , Kandeel Mahmoud , Radwan Nashwa 
Published: May 2024

Abstract
Background
Despite several justifications for utilizing beta-blockers, such as atenolol, as the initial treatment for hypertension in the presence of cardiovascular disease, some studies have demonstrated that calcium channel blockers were more effective than beta-blockers in decreasing mortality. This review intended to determine the efficacy of atenolol in reducing all-cause mortality in Asian individuals with hypertension, coronary artery disease, atrial fibrillation, and heart failure.

Main body of the abstract
Studies published before March 31, 2023, were searched using Trip, Google Scholar, Cochrane, and EMBASE databases. We only considered studies that compared atenolol with other medications in terms of all-cause mortality rates in Asian individuals diagnosed with hypertension and cardiovascular diseases. Therefore, we only considered three trials with a total of 79,603 participants. The results indicated a statistically significant higher all-cause death rate among non-atenolol users compared to atenolol users (p < 0.001). The all-cause death rate was considerably greater in individuals who consumed metoprolol tartrate compared to those who consumed atenolol (OR = 0.50, p < 0.0001). Although the included publications were deemed to have a low risk of bias, significant heterogeneity was observed (p = 0.001).

Short conclusion
Due to the limited studies included, this analysis concluded that atenolol, in comparison with non-users of atenolol or especially metoprolol tartrate, significantly reduces the overall death rate in East Asian and Southeast Asian patients with hypertension, coronary artery disease, atrial fibrillation, and heart failure. Yet, the current study cannot finalize this conclusion for other Asian ethnic groups, such as South Asians, Central Asians, and West Asians. Additional systematic reviews and meta-analyses with low heterogeneity and high-quality evidence are suggested to validate our findings and explore the efficacy of atenolol in various ethnic populations.
Quality and safety of new types of dairy products based on cow’s and mare’s milk with vegetable additives
Authors: Iztileuov Maxat , Ospanov Assan , Dikhanbayeva Fatima , Smailova Zhuldyz , Zhunussova Gulzat 
Published: May 2024

AbstractThe modern market of dairy products is quite developed, but the issue of compliance with the quality and safety of their production remains relevant. The purpose of this paper was to study the organoleptic, physicochemical and safety indicators of combined dairy products based on mare’s and cow’s milk using herbal supplements. In the course of the research, analytical and statistical methods of information processing were used; experimental studies of raw materials and the finished combined product, namely the determination of acidity, solids, fat and protein; energy and biological values of the product were calculated. Technological processes of combined dairy products based on cow’s and mare’s milk using a vegetable origin filler were studied. Of the three prototypes of the proposed dairy products, it was determined to recommend samples No. 2 and 3. High quality indicators are observed in them, in particular, a rich taste with a pronounced taste of additional components, a pleasant smell and appearance. Also, the finished product in samples No. 2 and 3 have high safety indicators. Pathogenic and harmful microorganisms and substances were not found, acceptable microorganisms are within the maximum permissible limits. According to the research results, new dairy products are recommended using vegetable raw materials with different fat, protein, energy value, caloric content and lactose content. In the process of writing this paper, indicators of nutritional, energy value and safety of new types of dairy products based on cow and mare’s milk with vegetable additives were determined. Taking into account the research results and the materials of previous scientific papers, authors consider it promising to develop and sell dairy products based on cow’s and mare’s milk using a filler of plant origin. The advantages of the resulting product include: consumer interest in such products, high quality indicators, product safety, the possibility of using products in functional and specialized nutrition.
Graphical Abstract
Applying the Consolidated Framework for Implementation Research to investigate factors of implementing alcohol screening and brief intervention among primary care physicians and nurses in Hong Kong, China: an exploratory sequential mixed-method study
Authors: Chan Paul Shing-fong , Fang Yuan , Xie Yao Jie , Wong Martin Chi-sang , Nilsen Per , Leung Sau-fong , Cheung Kin , Wang Zixin , Yeoh Eng-kiong 
Published: May 2024

Abstract
Background
Alcohol screening and brief intervention (SBI) is an evidence-based intervention recommended by the World Health Organization. This study applied the Consolidated Framework for Implementation Research (CFIR) to understand facilitators and barriers of SBI implementation in primary care settings in Hong Kong, China.

Methods
This was a sequential mixed-method study. In-depth interviews of 21 physicians and 20 nurses working in the primary care settings from the public and private sectors were first conducted to identify CFIR constructs that were relevant to SBI implementation in the Chinese context and potential factors not covered by the CFIR. A questionnaire was then developed based on the qualitative findings to investigate factors associated with SBI implementation among 282 physicians and 295 nurses.

Results
The in-depth interviews identified 22 CFIR constructs that were facilitators or barriers of SBI implementation in Hong Kong. In addition, the stigmatization of alcohol dependence was a barrier and the belief that it was important for people to control the amount of alcohol intake in any situation was mentioned as a facilitator to implement SBI. In the survey, 22% of the participants implemented SBI in the past year. Factors associated with the SBI implementation echoed most of the qualitative findings. Among physicians and nurses in both sectors, they were more likely to implement SBI when perceiving stronger evidence supporting SBI, better knowledge and self-efficacy to implement SBI, more available resources, and clearer planning for SBI implementation in the clinics but less likely to do so when perceiving SBI implementation to be complicated and of higher cost, and drinking approved by the Chinese culture. Participants were more likely to implement SBI when perceiving SBI fit better with the existing practice and better leadership engagement in the public sector, but not in the private sector. Perceiving a stronger need and greater importance to implement SBI were associated with higher likelihood of SBI implementation among physicians, but not among nurses. Perceiving better organizational culture supporting SBI was positively associated with SBI implementation among nurses, but not among physicians.

Conclusions
There was a significant gap between SBI evidence and its implementation. Some strategies to improve SBI implementation may be different between physicians and nurses and between those in the public and private sectors. The CFIR is a useful framework for understanding facilitators and barriers of SBI implementation in primary care settings.
Multiscale evaluation of tunnel construction safety risk: a case study of an offshore tunnel construction in Ningbo
Authors: Wu Ping , Lin Feng , Huang Jiamin , Xu Yidong 
Published: May 2024

AbstractBased on the WBS-RBS method, in this study, the risk factors corresponding to the construction risk events of an offshore tunnel foundation pit in Ningbo were identified, and the fuzzy comprehensive evaluation method was used to evaluate the construction safety risk of the project. The system-level risk value was obtained by using the risk event deformation resulting from changes in two factors, namely, “mechanical property of soil” and “stiffness of the envelope structure”, to calculate the new event-level risk value corresponding to the deformation using a finite element numerical model. The findings indicate that the tunnel project has a risk evaluation score of 62.78 and thus falls within the category of high-risk projects. A change in risk factors will alter the likelihood that risk events will occur, which affects the safety risk status of the entire project. When two factors are coupled, a project’s system-level risk can increase dramatically.
Development of the Prevention of Suicide Behaviour in Prisons: Enhancing Access to Therapy (PROSPECT) logic model and implementation strategies
Authors: Crook Rebecca , Lennox Charlotte , Awenat Yvonne , Edge Dawn , Knowles Sarah , Honeywell David , Gooding Patricia , Haddock Gillian , Brooks Helen , Pratt Daniel 
Published: May 2024

Aims and methodThis study aimed to develop and articulate a logic model and programme theories for implementing a new cognitive–behavioural suicide prevention intervention for men in prison who are perceived to be at risk of death by suicide. Semi-structured one-to-one interviews with key stakeholders and a combination of qualitative analysis techniques were used to develop programme theories.ResultsInterviews with 28 stakeholders resulted in five programme theories, focusing on: trust, willingness and engagement; readiness and ability; assessment and formulation; practitioner delivering the ‘change work’ stage of the intervention face-to-face in a prison environment; and practitioner training, integrating the intervention and onward care. Each theory provides details of what contextual factors need to be considered at each stage, and what activities can facilitate achieving the intended outcomes of the intervention, both intermediate and long term.Clinical implicationsThe PROSPECT implementation strategy developed from the five theories can be adapted to different situations and environments.
FASTOCH: Feasibility of Electronic Patient-Reported Outcomes in Older Patients With Cancer—A Multicenter Prospective Study
Authors: Cancel Mathilde , Sauger Carine , Biogeau Julie , Dardaine-Giraud Véronique , Lecomte Thierry , Solub David , Combe Pierre , Wilmet Rémy , Aubard Eugénie , Deloigne Amandine , Hébrard Philippe , Dorval Étienne 
Published: May 2024

PURPOSE Multiple studies have demonstrated that electronic patient-reported outcomes (ePROs) improve overall survival and quality of life in cancer care. However, there are no specific prospective data on remote ePRO monitoring in the older population, although they represent a significant proportion of patients with cancer. PATIENTS AND METHODS From February 2021 to April 2022, patients age 75 years and older under active anticancer treatment were consecutively recruited in six institutions. Remote ePRO feasibility was determined in intention-to-test (ITT) on the basis of the number of active users in the overall population. Primary failure applied to patients who had no Internet access or declined to test ePROs, while the other patients were assigned to the ITT population. Feasibility was also determined per-protocol on the basis of the number of active patients in the ITT population. RESULTS Of the 473 patients included, primary failure applied to 288 patients (233 of whom had no Internet access). Among the 185 patients in ITT, 122 used ePROs, leading to a 26% feasibility in ITT and a 66% feasibility per protocol. In a multivariate analysis, the intent to test population was from a higher socioprofessional category ( P = .009) and felt in better general condition in the Geriatric 8-score evaluation ( P = .002). Active patients significantly differed from the inactive on their self-assessment of a better general condition ( P < .001) only. CONCLUSION Our multicenter study showed a limited feasibility rate (26%) of remote ePROs monitoring for older patients with cancer, mainly because of technology barriers. Yet, among the patients who did have Internet access, most of them indeed used ePROs (66%). Given the expected benefit of ePROs, the technology barriers therefore need to be lifted to improve cancer care in older patients.
CAHQL: A Patient-Reported Outcome Instrument to Assess Health-Related Quality of Life in Congenital Adrenal Hyperplasia
Authors: Flokas Myrto Eleni , Yang Li , Middleton Kimberly R , Kollender Sarah , Parker Megan , Sukin Charles , Persky Rebecca Wood , Merke Deborah P 
Published: May 2024

Abstract

Context
Measuring health-related quality of life (HRQoL) is a crucial aspect of evaluating health care outcomes. Patients with congenital adrenal hyperplasia (CAH) often self-report deficiencies in HRQoL.

Objective
The aim of our study was to develop a disease-specific patient-reported outcome (PRO) instrument to evaluate the HRQoL of patients &gt; 16 years old with classic CAH.

Methods
Following the FDA guidelines for developing PRO instruments, we developed a conceptual framework for the instrument. A preliminary instrument was created after interviewing a representative sample of 12 patients (aged 16 to 68 years) with CAH and 3 parents and obtaining expert feedback from 4 endocrinologists. The instrument was edited after cognitive interviews with 6 patients. Internal consistency of the instrument was evaluated using Cronbach's alpha. Validity was assessed by comparing the scores of our instrument with scores from widely used validated instruments for HRQoL and PRO not specific to CAH.

Results
Sixty-nine patients 16 to 75 years old participated in validating our preliminary instrument. The final questionnaire consists of 44 questions within 7 domains: General Health, Adrenal Insufficiency, Glucocorticoid Excess, Physical Functioning, Mental Health and Cognition, Social Functioning, and Sexual Functioning, with acceptable internal consistency (Chronbach's alpha ≥ .6) and validity (r = −0.350 to 0.866).

Conclusion
CAHQL is the first validated PRO instrument to capture disease-specific HRQoL outcomes in CAH. In addition to its anticipated use in the clinical setting, the instrument could be used to assess the efficacy of novel treatments in development.
Distal Abdominal Oblique Avulsion Injuries in Two Collegiate Hockey Players: A Case Report
Authors: Narciso Ryan , Venis Lawrence , Cardoos Nathan 
Published: May 2024

AbstractWhile injuries to the abdominal oblique muscles near their origin at the lower ribs are commonly seen in sports that require explosive trunk rotational movements such as baseball and tennis, there are few reports in the literature of avulsion injuries to these muscles from their distal attachments at the iliac crest. We present the case of two collegiate male hockey players who suffered such injuries as a result of a direct impact mechanism while rotated at the waist. These injuries should be suspected when patients have significant pain in the lower abdominal region worsened by flexion and rotation of the trunk and can be accurately characterized by musculoskeletal ultrasound or MRI. With a conservative rehabilitation program focused on core, hip adductor, and hip flexor strengthening, our athletes were able to return to game participation within 6 wk of the initial injury.
Enhanced response over wavelength range of 7–12 µm for quantum wells in asymmetric micro-pillars
Authors: Wei-Wei Liu , Xin-Yang Jiang , Rui Xin , Li Yu , Hui Xia , Ning Li , Zhi-Feng Li , Wei Lu , Tian-Xin Li 
Published: May 2024

Efficient coupling in broad wavelength range is desirable for wide-spectrum infrared light detection, yet this is a challenge for intersubband transition in semiconductor quantum wells (QWs). High-Q cavities mostly intensify the absorption at peak wavelengths but with shrinking bandwidth. Here, we propose a novel approach to expand the operating spectral range of the Quantum Well Infrared Photodetectors (QWIPs). By processing the QWs into asymmetric micro-pillar array structure, the device demonstrates a substantial enhancement in spectral response across the wavelength from 7.1 µm to 12.3 µm with guided mode resonance (GMR) effects. The blackbody responsivity is then increased by 3 times compared to that of the 45° polished edge-coupled counterpart. Meanwhile, the dark current density remains unchanged after the deep etching process, which will benefit the electrical performance of the detector with reduced volume duty ratio. In contrast to the symmetric micro-pillar array that contains simple resonance mode, the detectivity of QWIP in asymmetric pillar structure is found to be improved by 2-4 times within the range of 9.5 µm to 15 µm.
Self-reported symptom burden among patients attending public health care facilities in India: Looking through ICPC-3 lens
Authors: Gupta Priti , Bharati Bhavna , Sundar Sahu Kirti , Mahapatra Pranab , Pati Sanghamitra 
Published: May 2024

Introduction
The objectives of this study were: 1) to describe the socio-demographics and classify the chief complaints and reasons to encounter facilities of patients presenting to public healthcare facilities; 2) to explore differences in these complaints and: International Classification of Primary Care-3 (ICPC-3) groups across socio-demographic and health system levels.

Methods
This is a cross-sectional study conducted in three districts of Odisha, India. Within each district, the district hospital (DH), one Sub-district hospital (SDH) (if available), two Community health centers (CHCs), and two Primary health care centers (PHCs) were selected. Thus, a total of three DHs, three SDHs, six CHCs, and six PHCs were covered. Two tertiary healthcare facilities were also included. Patients aged 18 years and older, attending the Outpatient Departments (OPD) of sampled health facilities were chosen as study participants through systematic random sampling.

Results
A total of 3044 patients were interviewed. In general, 65% of the sample reported symptoms as their chief complaint for reason of encounter, whereas 35% reported disease and diagnosis. The most common reasons to encounter health facilities were fever, hypertension, abdominal pain, chest pain, arthritis, skin disease, cough, diabetes, and injury. Among the symptoms, the highest number of patients reported the general category (29%), followed by the digestive system (16%). In the disease category, the circulatory system has the highest proportion, followed by the musculatory system. In symptom categories, general, digestive, and musculatory systems were the key systems for the reasons of encounter in outpatient departments irrespective of different groups of the population. In terms of different tiers of health systems, the top three reasons to visit OPD were dominated by the circulatory system, respiratory system, and musculatory system.

Conclusion
This is the first Indian study using the ICPC-3 classification for all three levels of health care. Irrespective of age, socio-economic variables, and tiers of healthcare, the top three groups to visit public health facilities according to the ICPC-3 classification were consistent i.e., general, digestive, and circulatory. Implementation of standard management and referral guidelines for common diseases under these groups will improve the quality and burden at public health facilities in India.
Nurturing care practices for children with developmental disabilities in sub-Saharan Africa: A scoping review protocol
Authors: Onyango Silas , Nampijja Margaret , Otwate Paul , Langat Nelson , Oloo Linda , Okelo Kenneth , Kitsao-Wekulo Patricia 
Published: May 2024

Background
The majority of children with neurodevelopmental disorders (NDDs) reside in low- and middle-income countries (LMICs). NDDs are a public health concern in countries in sub-Saharan Africa (SSA). Nurturing care has been recommended as a pathway for addressing the developmental needs and unlocking the full potential of children, including those with NDDs. However, little information exists on the strategies to support children with NDDs using the Nurturing Care Framework in many countries in SSA. This review aims to synthesize information on nurturing care practices for children with NDDs in SSA. The review will also determine gaps in the provision of nurturing care for children with NDDs. Further, the review will highlight the drivers of care as well as the experiences of the caregivers.

Methods
The review will be implemented in six steps: specification of the research question, identification of relevant studies, selection of studies to be included, extracting, mapping, and charting the data, collating, summarizing, and reporting the results, and stakeholder consultation. We propose a database search followed by a manual search for the literature synthesis. We will search the following electronic databases: PubMed, ScienceDirect, Scopus, Open Grey and African Journals Online (AJOL). All studies published after May 2018 to May 2023 that include relevant terms will be identified and included. The research team will develop a data extraction form for use in capturing relevant information from each of the included studies. A patterning chart that will summarize and analyze the key findings of each article will be created.

Discussion
We anticipate that the study will provide evidence on the existing nurturing care practices and unearth gaps in the provision of nurturing care for children with NDDs. Key determinants of care and the experiences of the parents/caregivers of children will also be identified. The study will provide key recommendations on interventions to improve the quality of care for children with NDDs. Through this study, awareness of the unmet nurturing care needs of these children will be increased. The evidence generated may assist policymakers and stakeholders in addressing the needs of children with NDDs.