bluuebunny/crossref_metadata_2025_split huggingface dataset:
BLOOD PRESSURE CONTROL AND CIRCADIAN RHYTHM AMONG PATIENTS WITH PROGRESSIVE GLAUCOMA – PRELIMINARY RESULTS
Authors: Wizner Barbara , Jedrychowska-jamborska Justyna , Sajak-hydzik Katarzyna , Pawlicka Ilona , Grodzicki Tomasz 
Published: May 2024

Objective:
Blood pressure (BP) control, postural changes and daily variability in patients with progressive glaucoma.

Design and method:
The study included 55 patients with different duration of open-angle glaucoma who had disease progression during the visit qualifying for this observational study. During two separate visits with 7 to 14 days interval, an ophthalmological and the clinical examination (standardized questionnaire, three BP measurements, orthostatic test, 24hour ABPM) were performed. The criterion for hypertension (HT) control in treated patients aged 80 years and over was office BP <150/90 mmHg. Postural hypotension was defined as a drop in systolic BP (SBP) of at least 20 mmHg and/or a drop in diastolic BP (DBP) of at least 10 mmHg within 1, 3, or 5 minutes after standing. The validated devices were used to obtain BP measurements.

Results:
The mean age of patients was 69 years, most subjects were over 60 years of age; 40% were men, 75% were treated for hypertension (HT).
∗Data from ABPM are currently available for 39 patients.
Patients with glaucoma progression noted in the short course of the disease (<5 years) were more likely to have uncontrolled HT in the office setting; in ABPM also had higher daytime SBP and greater daily SBP variability, although no statistical significance was observed. In turn, the oldest patients with long-term (>10 years) progressive glaucoma had too low nighttime SBP and DBP values.

Conclusions:
Conclusions. The results indicate an unfavorable prognostic impact of insufficient HT control and daily BP variability in people with a few years of glaucoma history. In the oldest patients, too low BP levels throughout the 24-hour period may contribute to its progression. Since most our patients had ABPM performed for the first time, emphasis should be placed on more frequent monitoring of circadian BP profile in glaucoma patients, especially among the oldest.
INFLUENCE OF ARTERIAL HYPERTENSION ON THE OCCURRENCE AND COURSE OF ATRIAL FIBRILLATION IN PATIENTS AFTER CORONAVIRUS DISEASE (COVID-19)
Authors: Stasyshena Oksana , Sychov Oleg , Marchenko Olena , Mikhalieva Tatiana , Torbas Olena , Getman Taisia , Romanova Olena , Sribna Olga 
Published: May 2024

Objective:
To determine the influence of arterial hypertension on the occurrence and course of atrial fibrillation (AF) in patients after suffering from the coronavirus disease (COVID-19).

Design and method:
The study included 187 patients aged 62.5±0.9 years (47% men, 53% women). The first three groups formed 116 patients who had AF and underwent COVID-19. The first group (G1) consisted of 36 patients who developed AF for the first time after COVID-19. The second group (G2) was represented by 25 patients in whom the transformation of the paroxysmal form of AF into persistent, or persistent AF into its permanent form occurred. The third group (G3) consisted of 55 patients in whom the form of AF did not change. Two control groups (CG) were also formed: control group 1 (CG1) - 49 patients with AF who did not have a history of COVID-19, and control group 2 (CG2) - 22 patients with extrasystole who experienced COVID-19, but who did not develop AF.

Results:
Arterial hypertension was a common comorbidity in patients with AF who underwent COVID-19. In patients who developed AF after COVID-19 (G1), arterial hypertension occurred 1.4 times more often (83,3% vs 59,1%, p<0.001) than in patients who suffered from COVID-19, but this type of arrhythmia did not develop (comparison CG 2). The presence of hypertension worsened the course of AF in patients who had this arrhythmia before COVID-19. Thus, in patients of G2, in whom AF transformation took place, in comparison with patients in whom the form of AF did not change G3 (88,4% vs 80,0%, p<0,05), hypertension occurred more often.

Conclusions:
Arterial hypertension is one of the most common diseases in patients with atrial fibrillation after the coronavirus infection, which contributed to the emergence of new paroxysms of AF and worsened the course of already existing arrhythmia.
IMPROVED ACCURACY OF LONG COVID-19 PREDICTION IN HOSPITALIZED HYPERTENSIVE PATIENTS COMPARED TO THE GENERAL COHORT
Authors: Honchar Oleksii , Ashcheulova Tetiana 
Published: May 2024

Objective:
The accuracy of prediction of Long COVID-19 development is currently suboptimal. Phenotyping a general post-COVID-19 population based on simple clinical and anamnestic criteria may be used to address this problem.
The purpose of this study was to identify the early predictors of Long COVID-19 syndrome at 3 months after discharge in hospitalized patients with a history of hypertension (HT).

Design and method:
221 hospitalized patients with COVID-19 (mean age 53.4+-13.6 years, 53% female, 40% with a history of hypertension) underwent comprehensive transthoracic echocardiography and a 6-minute walk test (6MWT) 1-2 days prior to discharge and after 1 month. A combination of logistic regression analysis and unsupervised machine learning was used to derive predictive models of self-assessed Long COVID-19 at 3 months after discharge (166 patients who have completed all visits comprised the final cohort).

Results:
Self-assessed Long COVID-19 at 3 months was detected in 50 (77%) of hypertensive and 74 (73%) of normotensive participants, p = 0,597. In the general cohort, a modest performance of 83% was observed in the validation subset for the derived pre-discharge predictors-based ML classification model, which only constituted to re-classification of 1/3 of otherwise false-positive cases compared to the assumption of 100% prevalence of Long COVID, with a total net reclassification improvement (NRI) of 8%. Phenotyping the general cohort based on the presence of hypertensive anamnesis significantly improved the predictive accuracy for the HT-positive subgroup: 100% accuracy was observed in the validation subset with an NRI of 23% vs baseline assumption, Chi-square test P < 0,001 vs the general cohort model confusion matrix. The derived models used sex, MRC dyspnea class, Charlson comorbidity index, and either (1) pre-discharge systolic BP and mitral E to left ventricular global longitudinal strain ratio, or (2) peak D-dimer, pre-discharge 6-minute walk distance, and peak capillary oxygen desaturation during the 6MWT.

Conclusions:
History of hypertension can be used as a phenotyping criterion to improve the accuracy of Long COVID-19 prediction among hospitalized patients: the derived ML-based classification models yielded a 100% predictive accuracy in the pre-specified validation subset of hypertensive patients hospitalized for acute COVID-19.
INFLUENCE OF CORONAVIRUS INFECTION ON VASCULAR REMODELING PARAMETERS IN PATIENTS WITH ARTERIAL HYPERTENSION
Authors: Atoyeva Munisa , Abdullayeva Go’Zal , Yusupova Khafiza , Masharipov Shuhrat , Khamidullayeva Gulnoz 
Published: May 2024

Objective:
to evaluate the effect of COVID19 on arterial stiffness parameters and microalbuminuria (MAU) baseline and in dynamics against the background of antihypertensive therapy (AHT) in patients with arterial hypertension (AH).

Design and method:
74 male and female patients with I-III degree of AH (ESH/ESC, 2018) were included in the study. Age was 53.54±1.92, duration of AH was 8.61.2 groups were identified: 1stgroup with AH who had suffered COVID19, no more than a month (N=42) and 2ndgroup with AH not suffered COVID19 (N=32).Vascular stiffness was determined by applanation tonometry using SphygmoCor apparatus (AtCor Medical, Australia); central systolic BP (CSBP), central diastolic BP (CDBP), central pulse pressure (CPP), aortic augmentation (AA), augmentation index (AIx), pulse wave velocity (PWV) were studied. The level of MAU was determined by enzymatic analysis on the biochemical analyser Daytona TM by Rendox (UK), which allows estimating MAU within the range of 30-300 mg/l and higher. The study was conducted before and after 6 months of AHT.p<0.05. The results are presented as μ±SD

Results:
The level ofMAU in 2ndgroup being 25,5±20,3 mg/l, in 1stgroup being 32,8±27,9 mg/l, but the difference was not significant (p>0,05). There was a significant decrease of MAU level in group I of patients: from 32,8±27,9 mg/l to 20,1±19,2,4 mg/l in dynamics (p<0,02). In 1st group, cSBP decreased from 154.86±24.11 to 134.38±13.9 mmHg (p<0.001) and in 2nd from 163.84±19.87 to 139.47±19.41 mmHg (p<0.001); cPP in 1stgroup decreased from 74.79±22.02 to 53.67±13.32 mmHg (p<0.001) and in 2ndgroup- from 78.84±14.48 to 54.71±12.46 mmHg (p<0.001). (p<0.001) and in 2ndgroup from 78.84±14.48 to 54.71±12.46 mmHg (p<0.001); PWV in 1stgroup decreased from 10.6±2.3 to 9.32±2.21 m/s (p<0.05) and in 2nd from 11.21±3.02 to 9.89±2.12 m/s (p<0.001). AA was significantly reduced only in 2nd: 19.24±7.67 mmHg before and 14.31±7.57 mmHg after(p<0.02) compared to 1stgroup: 15.67±6.97 before and 14.5±6.08 mmHg after treatment (p>0.05).

Conclusions:
The analysis of central haemodynamics and arterial stiffness parameters revealed positive dynamics of 6-month AHT in both studied groups of patients with advantage in the 2ndgroup. AA index significantly decreased only in the 2ndgroup. The level of MAU initially exceeded normal values in the 1stgroup
CARDIAC REMODELING IN PATIENTS WITH DIABETES MELLITUS AND CHRONIC KIDNEY DISEASE
Authors: Vasilkova Volha , Mokhort Tatsiana , Borovets Yana 
Published: May 2024

Objective:
To study the features of cardiac remodeling in patients with diabetes mellitus (DM) depending on the stage of chronic kidney disease (CKD).

Design and method:
We examined 499 patients with type 1 and type 2 diabetes mellitus older than 25 years. The laboratory examination of the patients included the measurement of serum creatinine, eGFR according to the CKD-EPI equation. An echocardiographic investigation was performed to study structural and geometric heart parameters. Left ventricular hypertrophy (LVH) was diagnosed when the left ventricular myocardial mass index (LVMI) exceeded 115 g/m2 in men and 95 g/m2 in women.

Results:
LVH was detected in 57.7% of patients with DM, while in the comparison group – in 35.4%. The frequency of LVH increased with a decrease in eGFR and was diagnosed in 100% of cases with CKD 5. In patients with DM, the left ventricular concentric remodeling significantly predominated (29.2%). Multiple linear regression analysis demonstrated the influence of age (ß=0.30, p=0.01) and serum creatinine (ß=0.15, p<0.0001) on the LVMI, independent of other factors, which confirms their independent pathogenetic significance.

Conclusions:
Patients with DM and CKD have structural and functional changes in the LV myocardium. Regardless of the nitrogen-excretion function of the kidneys, the predominant pattern of LV remodeling is concentric. The study of the features of structural and functional restructuring of the left heart in patients with diabetes should be taken into account in determining the cardiovascular prognosis.
ASSEMENT OF MYOCARDIAL MICROVASCULAR DYSFUNCTION IN PATIENTS WITH DIABETES MELLITUS: AN ADENOSINE STRESS PERFUSION CARDIAC MAGNETIC RESONANCE STUDY
Authors: Li Xinni , Shen Chenxing , Lu Zhigang , Liu Yuting , Kang Sang , Xiao Huoyuan , Ma Wenkun , Pan Jingwei 
Published: May 2024

Objective:
Coronary microvascular dysfunction (CMD) is an independent predictor of cardiovascular events in patients with diabetes, while glucose fluctuations worsen vascular lesions. This study aims to examine myocardial microvascular perfusion in patients with type 2 diabetes mellitus (T2DM) and to determine whether uncontrolled blood glucose levels lead to further deterioration of myocardial microvascular function.

Design and method:
Cardiac magnetic resonance (CMR) examinations were performed on 114 T2DM patients with complaints of atypical chest tightness and 55 matched controls. Obstructive coronary artery disease (CAD) was ruled out in all subjects, who were further divided into four subgroups: Q1 (T2DM-negative [–], glycated hemoglobin A1c [HbA1c] < 5.7%); Q2 (T2DM–, 5.7% <= HbA1c <= 6.4%); Q3 (T2DM-positive [+], HbA1c <7%; and Q4 (T2DM+, HbA1c >= 7%). The correlation between HbA1c levels and myocardial perfusion parameters was also evaluated.

Results:
Compared with controls, the myocardial perfusion reserve index (MPRI) in patients with T2DM was reduced (P < 0.001) due to decreased stress perfusion index (PI) (P < 0.001). MPRI was decreased in patients with uncontrolled T2DM (Q4) than in patients with controlled T2DM (Q3), with borderline significance (P = 0.065). Compared with controls (Q1), stress T1 reactivity (δT1) was significantly reduced in patients with controlled and uncontrolled T2DM (P = 0.004 and < 0.001, respectively), but elevated in patients with prediabetes (Q2) (P = 0.018). Extracellular volume (ECV) was significantly greater in patients with prediabetes and increased gradually in patients with controlled and uncontrolled T2DM compared with controls (P = 0.011, 0.001, and 0.007, respectively). Furthermore, HbA1c was negatively associated with MPRI and stress δT1, but positively correlated with ECV (β = -1.993, P < 0.001; β = 0.127, P < 0.001; and β = -0.180, P < 0.001, respectively).

Conclusions:
MPRI was negatively correlated with HbA1c, and its decrease in patients with T2DM was due to a lower increase in stress PI compared with controls. Stress δT1 decreased in patients with T2DM but increased in patients with prediabetes, indicating damage to microvascular perfusion in the prediabetic stage. Elevated ECV persists throughout diabetes.
MICROVASULAR ALTERATIONS IN PREDIABETES / PRELIMINARY REPORT
Authors: Liskiewicz-jankowska Martyna , Wolf Jacek , Dabrowska Edyta , Hellmann Marcin , Narkiewicz Krzysztof 
Published: May 2024

Objective:
Type 2 diabetes (T2DM) through various mechanisms increases CV risk, therefore early diagnosis is pivotal for patients prognosis. Microcirculation function and its’ structural changes may coincide or even precede overt cardiovascular disease in T2DM. Thus, microcirculation assessment holds potential to serve as early diagnostic window and/or basis for precision medicine strategies. Using novel microcirculation assessment techniques, in our study we focused on both structural and functional markers of abnormal microvascular bed performance in patients with glucose metabolism impairment.

Design and method:
Both, patients with (1) established diabetes, (2) prediabetes, and subjects (3) free of carbohydrates metabolism impairment were enrolled (n=180; 40% women). Microvascular phenotyping using RTX1 Adaptive Optics Retinal Camera (vessels remodeling denoted by wall-to-lumen ratio; WLR) and flow-mediated skin fluorescence (FMSF; hypoxia sensitivity; logHS) were performed.

Results:
Mean age of the studied population was 60.7 ±10.8 yo, BMI=29.9±4.8; Comparisons of WLR and logHS are presented in the figure. Patients with prediabetes had similar structural microcirculation phenotype as controls (left panel). However, prediabetic subjects were characterized by functional skin circulation abnormalities comparable to the ones evident in established T2DM (right panel). The observed differences were, however, lessened when age, and BMI status were included in the multivariate analyses.

Conclusions:
In patients with prediabetes, functional microcirculation alterations are present in the absence of structural changes of microvascular bed. The magnitude of these abnormalities are comparable to the ones seen in established diabetes. Our study however suggests that most of the differences in microcirculation misperformance in prediabetes are attributable to advancing age and higher body weight.
THE UTILITY OF BODY INDICES FOR DIABETES PREDICTION IN PATIENTS WITH FASTING HYPERGLYCEMIA: A 10-YEAR FOLLOW-UP STUDY
Authors: Kolesova Ekaterina , Rotar Oxana , Moguchaia Ekaterina , Boiarinova Maria , Erina Anastasia , Tolkunova Kristina , Kibkalo Sofia , Vasilieva Elena , Usoltsev Dmitry , Artomov Nikita , Maslyanskiy Alexey , Konradi Aleksandra 
Published: May 2024

Objective:
We aimed to compare the new body indices against traditional body mass index in their ability to predict diabetes development in patients with fasting hyperglycemia.

Design and method:
Baseline examination of population-based cohort was performed 2012-2013 in the framework of epidemiological study ESSE-RF which included questionnaires, anthropometry (weight, height, waist and hip circumference), laboratory tests (fasting glucose, glycated hemoglobin, lipids) and target organ damage assessment. In 2022-2023 patients with fasting hyperglycemia at baseline visit were re-examined to register onset of diabetes mellitus (DM), glucose and glycated hemoglobin levels. Several anthropometric indices were calculated: body mass index (BMI), waist-to-height ratio (WHtR), body shape index (ABSI), body roundness index (BRI), visceral adiposity index (VAI), Chinese visceral adiposity index (CVAI), and lipid accumulation product (LAP).

Results:
In total 72 participants were re-examined - 35 men and 37 women (mean age 43,6 years and 50,5 years, respectively). New onset of DM was confirmed in 15 patients (20,8%), in 6 men and 9 women. According to multiple regression analysis the most significant predictors of DM development were BRI (p=0,04, beta=-2,2) and WHTR (p=0,04, beta=2,94), but not BMI (p=0,42, beta=-0,22), model (R2 = 0.32; p=0,0014). After adjustment for traditional risk factors (sex, triglycerides, age, insulin, high density lipoproteins, waist circumference, glucose), the most significant diabetes predictors were the WHTR (p=0,01, beta=4,23) and VAI indices (p=0,04, beta=0,732), model (R2 = 0.547; p=1x10-4). We used individual body indices as predictors for the DM and estimated the area under the ROC curve (AUC). The AUC ROC for BRI, WHTR, CVAI and ABSI was greater than for traditional BMI, while for VAI and LAP indices performed worse than BMI (Table 1).

Conclusions:
New body composition indices involving advanced mathematical framework and including extended set of parameters - BRI, WHTR, CVAI and ABSI, are more reliable diabetes predictors than BMI in patients with fasting hyperglycemia after 10 years of follow-up.
This work was supported by the Ministry of Science and Higher Education of the Russian Federation
(Agreement # 075-15-2022-301) to A.Konradi.
IMPACT OF DIFFERENT TYPES OF HYPERTENSIVE DISORDERS OF PREGNANCY AND THEIR DURATION ON INCIDENT POST-PARTUM RISK OF DIABETES MELLITUS; RESULTS FROM A FRENCH NATIONWIDE STUDY
Authors: Olié Valerie , Lailler Grégory , Fosse-edorh Sandrine , Lebreton Élodie , Regnauld Nolwenn , Deneux-tharaux Catherine , Tsatsaris Vassilis , Plu-bureau Genevieve , Kretz Sandrine , Blacher Jacques 
Published: May 2024

Objective:
The reasons for the association between hypertensive disorders of pregnancy (HDP) and diabetes mellitus (DM) are poorly understood. Several studies have suggested an association between HDP and long-term onset of incident type 2 DM, irrespective of gestational diabetes status during pregnancy. The present study aimed to evaluate the impact of various types of HDP on the risk of incident DM.

Design and method:
We used data from the ongoing French nationwide prospective cohort study CONCEPTION which investigates the impact of HDP on women's health. For the present analysis, we included all primiparous women in CONCEPTION who had no personal history of DM prior to giving birth and who delivered between 2010 and 2018 (n=2,815,057 women). Follow-up spanned from childbirth to 31 December, 2021. HDP and incident DM onset during follow-up were identified using algorithms combining ICD-10 coded diagnoses during hospitalization and/or medication dispensing. We used Cox models

Results:
Pre-eclampsia and GH occurred in 2.6% and 4.6% of the study sample, respectively. During follow-up, 16 670 women had incident DM. The cumulative incidences of DM were 17.5% and 2.1% in women who had pre-eclampsia during pregnancy with and without concomitant gestational diabetes, respectively. The risk of DM was higher after HDP (all types) irrespective of gestational diabetes status during pregnancy. In women without gestational diabetes, compared with those who had no HDP, the risk of incident DM was higher in women who had GH (adjusted hazard ratio, aHR= 1.97 [1.81-2.16]), pre-eclampsia (aHR=2.42 [2.21-2.65]), and preexisting chronic hypertension prior to pregnancy (aHR=3.35 [3.03-3.70]). Early onset and severe pre-eclampsia were associated with a higher risk of DM. Finally, pre-eclampsia duration was significantly and positively associated with a higher risk of DM.

Conclusions:
Women who experienced an HDP had twice the risk of developing DM, even in the absence of gestational diabetes. Taking into account the phenotype and duration of pre-eclampsia could improve HDP risk stratification of pregnant women with a history of these disorders. Early concurrent blood glucose assessment and blood pressure monitoring should be more widely recommended after HDP diagnosis.
EVALUATION AND COMPARISON OF DIAGNOSTIC EFFICACY OF INDICATORS TO SCREENING FOR PRIMARY ALDOSTERONISM BEFORE ENDOCRINE PATHWAY
Authors: Wang Meng -HUI , Luo Qin , Li Nan -FANG 
Published: May 2024

Objective:
To evaluate and compare the effectiveness to screen for primary aldosteronism (PA) before the endocrine performing among hypokalemia, the serum sodium to urinary sodium to (serum potassium) to urinary potassium (SUSPPUP) index, combination of urine pH, sex, and serum potassium (PFK score) and PA-nomogram prediction model.2

Design and method:
From January 2010 to January 2014, 937 patients with hypertension were admitted in the People's Hospital of Xinjiang Uygur Autonomous Region. Fasting elbow venous blood was collected on admission day, serum, potassium, sodium and calcium ion levels were determined, calcium and phosphorus products were calculated, plasma sitting aldosterone/renin activity (ARR) were measured, and calculated. 24 h urine was collected and the ion level was measured. The pH value of urine was detected by pH test paper in the morning. Serum potassium (<3.5 mmol/L), SUSPPUP (>5.3/ (mmol/L)), PFK score (>2 points), nomogram prediction model (>21%) as positive screening criteria, ARR (>20ng/dL/ ng/mL/h) as positive endocrine screening index, were respectively used to predict and screen PA. The patients with positive ARR were confirmed PA using saline infusion test. The ROC curve was drawn to evaluate the efficacy of serum potassium, SUSPPUP, PFK score, and PA-nomogram prediction model to screen PA. Kappa test was used to evaluate its consistency with ARR screening results.

Results:
The area under ROC curve of serum potassium <3.5 mmol/L, SUSPPUP >5.3 (mmol/L)-1, PFK score >2 points, nomogram prediction probability>21% to screen PA in patients with hypertensive respectively were 0.61(95%CI:0.56∼0.66, P<0.001), 0.52(0.47∼0.57, P=0.479), 0.57(0.52∼0.62, P=0.005), 0.62(0.57∼0.67, P<0.001), and the sensitivity was 36%, 7%, 24% and 53%, the specificity was 86%, 96%, 90% and 70%, respectively. There was good consistency between nomogram prediction model or PFK score and ARR (Kappa=0.122, P <0.001, Kappa=0.092,P <0.001), and the Kappa value of nomogram prediction model with ARR was higher than the PFK score with ARR (X2=163.577, P < 0.001).

Conclusions:
The nomogram prediction model, which includes gender, serum potassium, calcium-phosphorus product and urine pH value, is more sensitive to screen PA in patients with hypertension, and the nomogram prediction probability>21% is more consistent with ARR.