bluuebunny/crossref_metadata_2025_split huggingface dataset:
SLC/CCR7 Stimulates the Proliferation of BMDCs by the pNF‐κB p65 Pathway
Authors: Zhou Shuang , Li Rilun , Qin Jie , Zhong Cuiping , Liang Chunmin 
Published: November 2009

AbstractThe chemokine receptor CCR7 is highly expressed in dendritic cells (DCs), T cells, and other immune effector cells. One of the high‐affinity ligand that can bind to CCR7 is the secondary lymphoid tissue chemokine (SLC). The SLC/CCR7 axis plays an important role in the immune system by inducing the chemotaxis and migration of immune effector cells. In this study, we examined the effect of SLC at different concentrations (0, 50, 100, 200, 300, and 400 ng/mL) on the proliferation of bone‐marrow‐derived dendritic cells (BMDCs). ELC (CCL19), another high‐affinity ligand for CCR7, was used as the control at the same time. We found that SLC directly stimulated the proliferation of BMDCs and enhanced the antigen‐presenting function and CCR7 expression. Western blot analysis showed that pNF‐κBp65 was involved in this mechanism. We also found that the NF‐κB inhibitor PDTC could specifically block the proliferation and CCR7 expression of BMDCs induced by SLC or ELC (200 ng/mL). The results suggested that there were cross‐talk signals between the chemotaxis and proliferation of BMDCs involving the SLC/CCR7 axis. Anat Rec, 2010. © 2009 Wiley‐Liss, Inc.
Occlusal Development and Masseter Activity in Alpacas (Lama pacos)
Authors: Williams Susan H. , Sidote Joanna , Stover Kristin K. 
Published: November 2009

AbstractTooth eruption and the development of occlusion are significant ontogenetic changes in the masticatory apparatus of mammals. Here, we test the hypothesis that changes in masseter activity are correlated with increased occlusal contacts at major stages of dental development in the alpaca, Lama pacos. We compare electromyographic data from the superficial and deep masseter in infant and juvenile alpacas prior to and following m1 occlusion and from adults with full permanent dentitions. The pre‐m1 and post‐m1 occlusion groups exhibit similar masseter activity durations, chewing cycle durations, and with the exception of the balancing‐side deep masseter, similar timing differences between the jaw muscles. On average, the balancing‐side deep masseter fires significantly later in the post‐m1 occlusion group. The m2–m3 group exhibits significantly longer chewing cycle length and an even later firing balancing‐side deep masseter. Increased occlusion is also associated with an increase in the relative amount of working‐side superficial and deep masseter muscle activity when compared with the balancing side muscles. Although the development of occlusal relations in infant and juvenile alpacas are associated with minor changes in masseter activation patterns, additional molar occlusal contacts increase chewing cycle duration resulting in concomitant changes in masseter recruitment patterns. Currently, we cannot rule out that musculoskeletal development influences masseter activity as demonstrated in other mammals. However, the data presented here indicate that alpacas have a relatively delayed onset of the adult motor pattern that may be correlated with changes in occlusal relations due to tooth eruption. Anat Rec, 2010. © 2009 Wiley‐Liss, Inc.
Developmental Pattern of the Right Atrioventricular Septal Valve Leaflet and Tendinous Cords
Authors: Guzmán Laura Villavicencio , Mayoral Pedro Valencia , Valencia Julio Páez , Pine Stanislaw Sadowinski , Gómez Concepción Sánchez 
Published: November 2009

AbstractNo consensus exists regarding the precise contribution of myocardium and the atrioventricular (AV) cushion mesenchyme to the development of leaflets, tendinous cords (TCs) and papillary muscles. Furthermore, the origin and fate of the myocardium embedded in the immature mesenchyme of the AV cushions at the beginning of AV valvulogenesis is controversial. Some authors have suggested that these cells result from a mesenchyme‐to‐myocardium transformation. In contrast, other researchers have concluded that they are derived from the myocardial ventricular wall and the interventricular septum (IVS). On the other hand, it has been assumed that the AV mural and septal leaflets have the same pattern of development. However the supporting structures of the two types of leaflets are anatomically different, which could reflect some differences in the pattern of development. We have therefore investigated the morphogenetic processes involved in sculpting and maturation of the right septal leaflet (RSL) and TCs in embryonic and post‐hatching chicken hearts. The origin and fate of the myocardium embedded in the immature cushion mesenchyme at the beginning of RSL morphogenesis was also studied. For this purpose, scanning electron microscopic analysis, histological studies and immunohistochemical detection of Nkx2.5 and MEF2C were performed. Our findings indicate that the RSL and TCs present a distinct morphogenetic pattern from that of the mural leaflets. Our results also provide evidence that myocardial recruitment from the IVS, but not mesenchyme‐to‐myocardium transformation, participates in the development of the muscular region of the TCs adjacent to the IVS. Anat Rec, 2010. © 2009 Wiley‐Liss, Inc.
The Effect of Maternal Malnutrition During Lactation on the Endometrial ERα Expression, Collagen Type, and Blood Vessels in the Rats Offspring at Puberty
Authors: Bittencourt Brasil Flávia , Silva Faria Tatiane , Barcellos Sampaio Francisco José , Fonte Ramos Cristiane da 
Published: November 2009

AbstractThe aim of this manuscript was to evaluate the effects of maternal protein‐energy‐restriction and energy restriction during lactation on endometrial collagen and blood vessels, uterus Erα expression, and estradiol serum levels in the rats offspring at puberty. At parturition, dams were grouped as: control group (C), with free access to standard rat chow containing 23% protein and 17,038.7 KJ/Kg; protein‐energy restricted group (PER), with free access to formulated chow containing 8% protein but made isoenergetic to the C diet (17,038.7 KJ/Kg); and energy‐restricted group (ER), which received standard rat chow containing 23% protein based on the mean ingestion of the PER group corresponding to 60% of that consumed by the control group. After weaning, all female pups had free access to standard laboratory chow until puberty, when they were killed at the diestrum stage. The uterine ERα expression was determined by Western‐Blot and estradiol serum levels by radioimmunoassay. Endometrial collagen and blood vessels were quantified by stereology. The volumetric density of blood vessels (C = 70.7 ± 2.2; PER = 29.2 ± 2.4; ER = 32.3 ± 3.6; P < 0.001) and endometrial collagen (C = 31.1 ± 1; PER = 26.9 ± 1.0; ER = 26.5 ± 0.7; P < 0.05) were significantly reduced in both malnourished groups. The ER group presented higher estradiol serum levels (C = 69.2 ± 6.4; PER = 73.4 ± 5.5; ER = 101.0 ± 5.4; P < 0.01) in relation to C and PER groups. ERα expression was greater in both malnourished groups (C = 0.11 ± 0.02; PER = 0.41 ± 0.12; ER = 0.35 ± 0.03; P < 0.05). In conclusion, maternal malnutrition during lactation caused changes in endometrial angiogenesis, collagen deposition, and Erα expression in female offspring that will appear in puberty and could affect the reproductive biology of the female offspring. Anat Rec, 2010. © 2009 Wiley‐Liss, Inc.
Antifertility Characteristics of the N‐terminal Region of Mouse Equatorial Segment Protein
Authors: Lv Zheng‐Mei , Wang Min , Xu Chen 
Published: November 2009

AbstractTo investigate antifertility characteristics of the equatorial segment protein (ESP) and its potential immunocontraceptive effect, three partially overlapping cDNA fragments P1/P2/P3, together covering the entire mouse ESP, were cloned, expressed, and purified. The roles of P1/P2/P3 in fertility were investigated through in vitro fertilization and mouse mating test. Antibodies against P1/P2 significantly reduced the rates of fertilization in vitro in the zona‐intact experiments. Coincubation of zona‐free mouse oocytes with capacitated mouse spermatozoa in the presence of antibodies against P1/P2 also inhibited sperm‐oolemma binding and fusion, while anti‐P3 antibody virtually had no effect on in vitro fertilization at the same concentration. Immunization of female BALB/c mice with N‐terminal of mouse ESP (recombinant P1 and P2) resulted in a significant decrease in the fertility rate as well as the litter size. Double immunofluorescence staining showed that mouse ESP protein was localized to the equatorial segment of acrosome of mouse sperm, and was exposed and surface‐accessible after acrosome reaction. Mouse ESP was also demonstrated to have complementary binding sites on the mouse egg plasma membrane by indirect immunofluorescence assay. These findings suggest that the N‐terminal of mouse ESP could play an important role in fertility and might be a vaccine candidate for contraception. Anat Rec, 2010. © 2009 Wiley‐Liss, Inc.
Synthesis and Antimycobacterial Activity of a Novel Series of Isonicotinylhydrazide Derivatives
Authors: Jaju Sandip , Palkar Mahesh , Maddi Veeresh , Ronad Pradeepkumar , Mamledesai Shivalingarao , Satyanarayana Darbhamulla , Ghatole Mangala 
Published: November 2009

AbstractA novel series of 14 new isonicotinyl hydrazide derivatives 2a–g, 3a–g containing a 4‐thiazolidinone / 2‐azetidinone nucleus were synthesized by reacting N′‐substituted arylidene / heteroarylidene isonicotinyl hydrazide 1a–g with thioglycollic acid in the presence of dry benzene and with chloroacetyl chloride in the presence of triethylamine, respectively. Structures of all newly synthesized compounds were characterized on the basis of elemental analyses and spectral data (IR and 1H‐NMR). All the title compounds were tested for their in‐vitro antimycobacterial activity against Mycobacterium tuberculosis H37Rv using Alamar‐Blue susceptibility test, and the activity is expressed as the minimum inhibitory concentration (MIC) in μg/mL. Among the series, compounds 2b, 2g, 3b, and 3g displayed an encouraging antimycobacterial activity profile as compared to that of the reference drugs isoniazid / rifampicin.
Design, Synthesis, and Antifungal Activity of Novel Conformationally Restricted Triazole Derivatives
Authors: Wang Wenya , Sheng Chunquan , Che Xiaoying , Ji Haitao , Miao Zhenyuan , Yao Jianzhong , Zhang Wannian 
Published: November 2009

AbstractA series of new triazole derivatives were designed and synthesized on the basis of the active site of lanosterol 14α‐demethylase from Candida albicans (CACYP51). 2‐(2,4‐Difluorophenyl)‐3‐(methyl‐(3‐phenoxyalkyl)amino)‐1‐(1H‐1,2,4‐triazol‐1‐yl)propan‐2‐ols show excellent in‐vitro activity against most of the tested pathogenic fungi. The MIC80 value of compound 8a against Candida albicans is 0.01 μM, which provides a good starting template for further structural optimization. The binding modes of the designed compounds were investigated by flexible molecular docking. The compounds interacted with CACYP51 through hydrophobic, van‐der‐Waals, and hydrogen‐bonding interactions.
N‐Malonyl‐1,2‐dihydroisoquinoline as a Novel Carrier for Specific Delivery of Drugs to the Brain
Authors: Abdel‐Aziz Mohamed , Abuo‐Rahma Gamal El‐Din A. A. , Hassan Heba A. , Farag Hassan H. 
Published: November 2009

AbstractN‐Malonyl‐1,2‐dihydroisoquinoline derivatives were synthesized and investigated as a novel carrier system for site‐specific and sustained delivery of drugs to the brain. Such carriers are expected to be stable against air oxidation due to the presence of the carbonyl group close to nitrogen of the dihydroisoquinoline. Reduction of the prepared isoquinolinium quaternary derivatives with sodium dithionite afforded a novel group of N‐malonyl‐1,2‐dihydroisoquinoline chemical delivery systems (CDS). The synthesized N‐malonyl‐1,2‐dihydroisoquinoline chemical delivery systems were subjected to various chemical and biological investigations to evaluate their ability to cross the blood‐brain barrier (BBB), and to be oxidized biologically into their corresponding quaternary derivatives. The in‐vitro oxidation studies showed that the designed N‐malonyl‐1,2‐dihydroisoquinoline chemical delivery system could be oxidized into its corresponding quaternary derivatives at an adequate rate. The in‐vivo distribution studies showed that these N‐malonyl‐1,2‐dihydroisoquinoline chemical delivery systems were able to cross the blood‐brain barrier at detectable concentrations.
Analyzing user interaction with the ViewFinder video retrieval system
Authors: Albertson Dan 
Published: November 2009

AbstractThis study investigates interactive video retrieval. The basis for this study is that user‐ and search task‐centric research in video information retrieval can assist efforts for developing effective user interfaces and help complement the existing corpus of video retrieval research by providing evidence for the benefits of evaluating systems using such an approach. Accordingly, the results were collected and analyzed from the perspective of certain users and search tasks (i.e., information needs). The methodology of this study employed specially designed interactive search experiments to examine a number of different factors in a video retrieval context, including those that correspond to search tasks of a particular domain, interface features and functions, system effectiveness, and user interactions. The results indicated that the use and effectiveness of certain interface features and functions were dependent on the type of search task, while others were more consistent across the full experiment. Also included is a review of prior research pertaining to visual search tasks, systems development, and user interaction. ViewFinder, the prototype system used to carry out the interactive search experiments of this study, is fully described.
Biofuels, trade and sustainability: a review of perspectives for developing countries
Authors: Oosterveer Peter , Mol Arthur P.J. 
Published: November 2009

AbstractRecent growth in demand for biofuels is resulting in rapid increases in their production and trade. Although this may offer interesting export opportunities for tropical countries who can produce biomass more efficiently, whether this effectively leads to growing exports depends to a large extent on the conditionalities that prevail on the major biofuel markets. Market protection by developed countries, concerns about the environmental impact of producing biofuels, and demands for securing food production are all conditions preventing the world biofuels market from being a level playing field. These conditions for international trade are not yet fixed, however, and various stakeholders struggle with the desired arrangement. This review provides an overview of the state‐of‐the‐art biofuels trade, with special emphasis on issues of access, trade barriers and sustainability relevant for developing countries. Copyright © 2009 Society of Chemical Industry and John Wiley & Sons, Ltd
Study of stationary phase metabolism via isotopomer analysis of amino acids from an isolated protein
Authors: Shaikh Afshan S. , Tang Yinjie J. , Mukhopadhyay Aindrila , Martín Héctor García , Gin Jennifer , Benke Peter I. , Keasling Jay D. 
Published: November 2009

AbstractMicrobial production of many commercially important secondary metabolites occurs during stationary phase, and methods to measure metabolic flux during this growth phase would be valuable. Metabolic flux analysis is often based on isotopomer information from proteinogenic amino acids. As such, flux analysis primarily reflects the metabolism pertinent to the growth phase during which most proteins are synthesized. To investigate central metabolism and amino acids synthesis activity during stationary phase, addition of fully 13C‐labeled glucose followed by induction of green fluorescent protein (GFP) expression during stationary phase was used. Our results indicate that Escherichia coli was able to produce new proteins (i.e., GFP) in the stationary phase, and the amino acids in GFP were mostly from degraded proteins synthesized during the exponential growth phase. Among amino acid biosynthetic pathways, only those for serine, alanine, glutamate/glutamine, and aspartate/asparagine had significant activity during the stationary phase. © 2009 American Institute of Chemical Engineers Biotechnol. Prog., 2010
ChemInform Abstract: Crystallography of Chevrel Phases, MMo6T8 (M: Cd, Na, Mn, and Zn, T: S, Se) and Their Cation Mobility.
Authors: Levi E. , Gershinsky G. , Aurbach D. , Isnard O. 
Published: November 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Lithium Carnallite, LiCl·MgCl2·7H2O.
Authors: Schmidt Horst , Euler Bernhard , Voigt Wolfgang , Heide Gerhard 
Published: November 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Phase in the Al—Yb—Zn System Between 25 and 50 at% Ytterbium.
Authors: Mazzone Donata , Manfrinetti Pietro , Fornasini Maria L. 
Published: November 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Structure—Composition Sensitivity in “Metallic” Zintl Phases: A Study of Eu(Ga1‐xTtx)2 (Tt: Si, Ge, 0 ≤ x ≤ 1).
Authors: You Tae‐Soo , Zhao Jing‐Tai , Poettgen Rainer , Schnelle Walter , Burkhardt Ulrich , Grin Yuri , Miller Gordon J. 
Published: November 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Tuning the Sign of Photoinduced Changes in Magnetization: Spin Transitions in the Ternary Metal Prussian Blue Analogue NaαNi1‐xCox [Fe(CN)6]β·nH2O.
Authors: Pajerowski Daniel M. , Gardner Justin E. , Talham Daniel R. , Meisel Mark W. 
Published: November 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: The Magnetic Structure of Clinopyroxene‐Type LiFeGe2O6 and Revised Data on Multiferroic LiFeSi2O6.
Authors: Redhammer Guenther J. , Roth Georg , Treutmann Werner , Hoelzel Markus , Paulus Werner , Andre Gilles , Pietzonka Clemens , Amthauer Georg 
Published: November 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: EuTZn (T: Pd, Pt, Au) with TiNiSi‐Type Structure—Magnetic Properties and 151Eu Moessbauer Spectroscopy.
Authors: Mishra Trinath , Hermes Wilfried , Harmening Thomas , Eul Matthias , Poettgen Rainer 
Published: November 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Clewlike ZnV2O4 Hollow Spheres: Nonaqueous Sol—Gel Synthesis, Formation Mechanism, and Lithium Storage Properties.
Authors: Xiao Lifen , Zhao Yanqiang , Yin Jia , Zhang Lizhi 
Published: November 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Ionothermal Synthesis of the Mixed‐Anion Material, Ba3Cl4CO3.
Authors: Leyva‐Bailen Patricia , Vaqueiro Paz , Powell Anthony V. 
Published: November 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Investigation of the New P′3‐Na0.60VO2 Phase: Structural and Physical Properties.
Authors: Szajwaj Olivier , Gaudin Etienne , Weill Francois , Darriet Jacques , Delmas Claude 
Published: November 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis, Crystal Structure, Spectroscopic and Thermal Properties of [Et4N] [Ta6Br12(H2O)6] Br4·4H2O (Et: Ethyl) — A New Compound with the Paramagnetic [Ta6Br12]3+ Cluster Core.
Authors: Peric Berislav , Jozic Drazan , Planinic Pavica , Brnicevic Nevenka , Giester Gerald 
Published: November 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Bis(tetraphenylphosphonium) (hexasulfido‐2ϰ2S1,S6) di‐μ‐sulfido‐disulfido‐1ϰ2S‐tungsten(VI)zinc(II) Acetone Solvate.
Authors: Beheshti Azizolla , Clegg William , Dale Sophie H. , Hyvadi Reza 
Published: November 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Poly(polyoxotungstate)s with 20 Nickel Centers: From Nanoclusters to One‐Dimensional Chains.
Authors: Zheng Shou‐Tian , Zhang Jie , Clemente‐Juan Juan Modesto , Yuan Da‐Qiang , Yang Guo‐Yu 
Published: November 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Asymmetric Hydrogenation and Allylic Substitution Reaction with Novel Chiral Pinene‐Derived N,P‐Ligands.
Authors: Meng Xiangyan , Li Xinsheng , Xu Dongcheng 
Published: November 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.