bluuebunny/crossref_metadata_2025_split huggingface dataset:
Investigating impression management use in asynchronous video interviews across 10 countries
Authors: Arseneault René , Roulin Nicolas 
Published: April 2024

AbstractThis cross‐cultural study investigates how interviewees from 10 culturally‐distinct countries differ in their use of impression management (IM) tactics in asynchronous video interviews (AVIs), and the relationship(s) between those tactics and interview performance. A total of 582 participants from ten countries (India, Canada, South Africa, Poland, Spain, Iran, Germany, Chile, Philippines, China) completed an 8‐question AVI for a mock position as a manager in a bank. We drew upon GLOBE's cultural framework to predict and explain observed differences in self‐reported IM use and performance. We used multi‐level modeling to test our hypotheses. Interviewees from our ten countries differed slightly in their IM use for various tactics, but IM use was seldom related to GLOBE cultural dimensions. Partially consistent with previous in‐person interview research, honest IM tactics (e.g., self promotion) were positively, but deceptive tactics (e.g., extensive image creation) negatively, associated with interview performance. This research is the first to investigate cross‐cultural IM differences in AVIs, thus addressing a critical gap in the selection literature at a time when many organizations conduct interviews virtually to save costs, streamline the hiring process, or simply conduct most of their activities remotely.
Resequencing of Brazilian locally adapted cattle breeds revealed variants in candidate genes and transcription factors for meat fatty acid profile
Authors: Vieira João Inácio Gomes , Braga Larissa Graciano , Chud Tatiane C. S. , Ferreira Pablo Henrique , Guimarães Simone Eliza Facioni , Martins Marta Fonseca , do Carmo Panetto João Cláudio , Machado Marco Antonio , Silva Danielly Beraldo dos Santos , Bonafé Cristina Moreira , Magalhães Ana Fabrícia Braga , da Silva Marcos Vinícius G. B. , Verardo Lucas Lima 
Published: April 2024

AbstractThe beef cattle industry has experienced a shift driven by a market demand for healthier meat, cost efficiency and environmental sustainability in recent years. Consequently, there has been a growing focus on the fatty acids content and functions of meat in cattle breeding programmes. Besides, a deeper understanding of the biological mechanisms influencing the expression of different phenotypes related to fatty acid profiles is crucial. In this study, we aimed to identify Single‐Nucleotide Variants (SNV) and Insertion/Deletion (InDels) DNA variants in candidate genes related to fatty acid profiles described in genomic, transcriptomic and proteomic studies conducted in beef cattle breeds. Utilizing whole‐genome re‐sequencing data from Brazilian locally adapted bovine breeds, namely Caracu and Pantaneiro, we identified SNVs and InDels associated with 23,947 genes. From these, we identified 318 candidate genes related to fatty acid profiles that contain variants. Subsequently, we select only genes with SNVs and InDels in their promoter, 5′ UTR and coding region. Through the gene–biological process network, approximately 19 genes were highlighted. Furthermore, considering the studied trait and a literature review, we selected the main transcription factors (TF). Functional analysis via gene–TF network allowed us to identify the 30 most likely candidate genes for meat fatty acid profile in cattle. LIPE, MFSD2A and SREBF1 genes were highlighted in networks due to their biological importance. Further dissection of these genes revealed 15 new variants found in promoter regions of Caracu and Pantaneiro sequences. The gene networks facilitated a better functional understanding of genes and TF, enabling the identification of variants potentially related to the expression of candidate genes for meat fatty acid profiles in cattle.
Sirt7/HIC1 complex participates in hyperglycaemia‐mediated EndMT via modulation of SDC1 expression in diabetic kidney disease and metabolic memory
Authors: Lu Lihong , Zhu Minmin , Wu Qichao , Sun Zhirong , Chen Xiangyuan , Miao Changhong 
Published: April 2024

AbstractDiabetic kidney disease (DKD), a primary microvascular complication arising from diabetes, may result in end‐stage renal disease. Epigenetic regulation of endothelial mesenchymal transition (EndMT) has been recently reported to exert function in metabolic memory and DKD. Here, we investigated the mechanism which Sirt7 modulated EndMT in human glomerular endothelial cells (HGECs) in the occurrence of metabolic memory in DKD. Lower levels of SDC1 and Sirt7 were noted in the glomeruli of both DKD patients and diabetes‐induced renal injury rats, as well as in human glomerular endothelial cells (HGECs) with high blood sugar. Endothelial‐to‐mesenchymal transition (EndMT) was sustained despite the normalization of glycaemic control. We also found that Sirt7 overexpression associated with glucose normalization promoted the SDC1 expression and reversed EndMT in HGECs. Furthermore, the sh‐Sirt7‐mediated EndMT could be reversed by SDC1 overexpression. The ChIP assay revealed enrichment of Sirt7 and H3K18ac in the SDC1 promoter region. Furthermore, hypermethylated in cancer 1 (HIC1) was found to be associated with Sirt7. Overexpression of HIC1 with normoglycaemia reversed high glucose‐mediated EndMT in HGECs. The knockdown of HIC1‐mediated EndMT was reversed by SDC1 upregulation. In addition, the enrichment of HIC1 and Sirt7 was observed in the same promoter region of SDC1. The overexpressed Sirt7 reversed EndMT and improved renal function in insulin‐treated diabetic models. This study demonstrated that the hyperglycaemia‐mediated interaction between Sirt7 and HIC1 exerts a role in the metabolic memory in DKD by inactivating SDC1 transcription and mediating EndMT despite glucose normalization in HGECs.
Malvidin attenuates trauma‐induced heterotopic ossification of tendon in rats by targeting Rheb for degradation via the ubiquitin‐proteasome pathway
Authors: Jiang Huaji , Ding Yan , Lin Xuemei , Tian Qinyu , Liu Yakui , He Hebei , Wu Yongfu , Tian Xinggui , Zwingenberger Stefan 
Published: April 2024

AbstractThe pathogenesis of trauma‐induced heterotopic ossification (HO) in the tendon remains unclear, posing a challenging hurdle in treatment. Recognizing inflammation as the root cause of HO, anti‐inflammatory agents hold promise for its management. Malvidin (MA), possessing anti‐inflammatory properties, emerges as a potential agent to impede HO progression. This study aimed to investigate the effect of MA in treating trauma‐induced HO and unravel its underlying mechanisms. Herein, the effectiveness of MA in preventing HO formation was assessed through local injection in a rat model. The potential mechanism underlying MA's treatment was investigated in the tendon‐resident progenitor cells of tendon‐derived stem cells (TDSCs), exploring its pathway in HO formation. The findings demonstrated that MA effectively hindered the osteogenic differentiation of TDSCs by inhibiting the mTORC1 signalling pathway, consequently impeding the progression of trauma‐induced HO of Achilles tendon in rats. Specifically, MA facilitated the degradation of Rheb through the K48‐linked ubiquitination‐proteasome pathway by modulating USP4 and intercepted the interaction between Rheb and the mTORC1 complex, thus inhibiting the mTORC1 signalling pathway. Hence, MA presents itself as a promising candidate for treating trauma‐induced HO in the Achilles tendon, acting by targeting Rheb for degradation through the ubiquitin‐proteasome pathway.
Efficacy and safety of a new heterologous fibrin biopolymer on socket bone healing after tooth extraction: An experimental pre‐clinical study
Authors: Bighetti Ana Carolina Cestari , Cestari Tania Mary , Paini Suelen , Pomini Karina T. , Buchaim Daniela Vieira , Ortiz Rafael Carneiro , Júnior Rui Seabra Ferreira , Barraviera Benedito , Bullen Izabel R. F. R. , Garlet Gustavo Pompermaier , Buchaim Rogério Leone , de Assis Gerson F. 
Published: April 2024

AbstractAimTo assess the efficacy of heterologous fibrin biopolymer (HFB) in promoting alveolar bone healing after tooth extraction in rats.Materials and MethodsThe upper right incisors of 48 Wistar rats were extracted. Toothless sockets were filled with HFB (HFBG, n = 24) or blood clot (BCG, n = 24). The tooth extraction sites were subjected to micro‐computed tomography (micro‐CT), histological, histomorphometric and immunohistochemical (for Runt‐related transcription factor 2/Runx2 and tartrate‐resistant acid phosphatase/TRAP) analyses on days 0, 7, 14 and 42 after extraction.ResultsSocket volume remained similar between days 0 and 14 (69 ± 5.4 mm3), except in the BCG on day 14, when it was 10% lower (p = .043). Although the number of Runx2+ osteoblasts was high and similar in both groups (34 × 102 cells/mm2), the HFBG showed lower inflammatory process and osteoclast activity than BCG at 7 days. On day 14, the number of Runx2+ osteoblasts remained high and similar to the previous period in both groups. However, osteoclast activity increased. This increase was 55% lower in the HFBG than BCG. In the BCG, the presence of an inflammatory process and larger and numerous osteoclasts on day 14 led to resorption of the alveolar bone ridge and newly formed bone. On day 42, numbers of Runx2+ osteoblast and TRAP+ osteoclasts decreased dramatically in both groups. Although the BCG exhibited a more mature cortical bone formation, it exhibited a higher socket reduction (28.3 ± 6.67%) and smaller bone volume (37 ± 5.8 mm3) compared with HFBG (socket reduction of 14.8 ± 7.14% and total bone volume of 46 ± 5.4 mm3).ConclusionsHFB effectively suppresses osteoclast activity and reduces alveolar bone resorption compared with blood clot, thus preventing three‐dimensional bone loss, particularly during the early healing period. HFB emerges as a promising biopharmaceutical material for enhancing healing processes after tooth extraction.
Performance of MAST, FAST, and MEFIB in predicting metabolic dysfunction‐associated steatohepatitis
Authors: Qi Shi , Wei Xiaodie , Zhao Jinhan , Wei Xinhuan , Guo Haiqing , Hu Jingxian , WuYun Qiqige , Pan Calvin Q. , Zhang Nengwei , Zhang Jing 
Published: April 2024

AbstractBackground and AimTo identify individuals with metabolic dysfunction‐associated steatohepatitis (MASH) or “at‐risk” MASH among patients with metabolic dysfunction‐associated steatotic liver disease (MASLD), three noninvasive models are available with satisfactory efficiency, which include magnetic resonance imaging [MRI]‐ AST (MAST), FibroScan‐AST (FAST score), and magnetic resonance elastography [MRE] plus FIB‐4 (MEFIB). We aimed to evaluate the most accurate approach for diagnosing MASH or “at‐risk” MASH.MethodsWe included 108 biopsy‐proven MASLD patients who underwent simultaneous assessment of MRE, MRI proton density fat fraction (MRI‐PDFF), and FibroScan scans. Compared with the histological diagnosis, we analyzed the AUC of each model and assessed the accuracy.ResultsOur study cohort consisted of 64.8% of MASH and 25.9% of “at‐risk” MASH. When analyzing the performance of each model for the diagnostic accuracy of MASH, we found that the AUC [95% CI] of MAST was comparable to FAST (0.803 [0.719–0.886] vs 0.799 [0.707–0.891], P = 0.930) and better than MEFIB (0.671 [0.571–0.772], P = 0.005). Similar findings were observed in the “at‐risk” MASH patients. The AUCs [95% CI] for MAST, FAST, and MEFIB were 0.810 [0.719–0.900], 0.782 [0.689–0.874], and 0.729 [0.619–0.838], respectively. The models of MAST and FAST had comparable AUCs (P = 0.347), which were statistically significantly higher than that of MEFIB (P = 0.041). Additionally, the cutoffs for diagnosis of MASH were lower than “at‐risk” MASH.ConclusionMAST and FAST performed better than MEFIB in diagnosing “at‐risk” MASH and MASH using lower cutoff values. Our findings provided evidence for selecting the most accurate noninvasive model to identify patients with MASH or at‐risk MASH.
Criteria for evaluating the effectiveness of psychiatric home care–mobile team: A systematic review of the literature
Authors: Adrien Vladimir , Diot Thomas 
Published: April 2024

AbstractAimTo explore criteria evaluating the effectiveness of psychiatric home care–mobile team practices, that have been developed widely in the last decades.DesignSystematic review of the literature.MethodsWe included 24 studies published between January 2010 and October 2023.Data SourcesCINAHL, APA PsycInfo, Embase, Scopus and PubMed.ResultsThe evaluation criteria differed according to the studies: impact on hospital stay, symptomatic clinical impact, repercussions on functioning, quality of life, analysis of profitability, safety, therapeutic alliance and finally, cooperation network.ConclusionThe variability of the criteria used to judge the effectiveness of psychiatric home care–mobile team practices shows their richness and diversity, and the absence of standardisation.Implications for the Profession and Patient CareThe variability of the criteria used to judge the effectiveness of psychiatric home care–mobile team practices supports a qualitative and multidisciplinary approach, with enhanced teamwork.ImpactPsychiatric home care–mobile team practice have widely developed in the last years and their effectiveness need to be evaluated. Our main finding is that there is a rich variety of practices and that evaluation criteria are very diverse, thus not standardised. We suggest using a mixed‐method approach to capture the subjective experience of patients and caregivers. These findings also highlight the significance of institutional cooperative work and call for a redefinition of team construction.Reporting MethodThe authors adhered to PRISMA guidelines.Patient or Public ContributionNo patient or public contribution.
Effect of bolus property on swallowing dynamics in patients with dysphagia
Authors: Hino Haruka , Suzuki Taku , Maekawa Kazuya , Ita Reiko , Sasa Anna , Kulvanich Sirima , Takei Eri , Magara Jin , Tsujimura Takanori , Inoue Makoto 
Published: April 2024

AbstractBackgroundModification of foods or liquids is commonly administered as part of dysphagia treatment. However, no consensus exists on the parameters for defining texture‐modified food for patients with dysphagia.ObjectivesThe aim of this study was to evaluate the effect of food/liquid material on swallowing physiology in patients with dysphagia and to discuss the optimal food choice for direct swallowing therapy.Materials and MethodsA total of 140 patients underwent a videofluoroscopic swallowing study using three test foods/liquids: 3 mL of mildly thick liquid (Thick liquid), jelly made of agar and polysaccharide (Jelly) and jelly made of pectin (Reset gel). Outcome measures of videofluoroscopic images, bolus transit time and hyoid movements were compared.ResultsThe frequency of chewing movements was highest for Jelly, followed by Reset gel and Thick liquid. While the probability of oral residue was the highest for Reset gel, pharyngeal residue after swallowing was high for Thick liquid as compared to Jelly and Reset gel. Oral transit time and pharyngeal transit time for Thick liquid were significantly smaller than that for Jelly and Reset gel. Pharyngeal delay time was significantly smaller for Thick liquid than that for Jelly and Reset gel. There was no difference in hyoid elevation time and hyoid movement time among the conditions.ConclusionMildly thick liquid material may be optimal for patients with primarily oral motor function impairment and jelly, such as Reset gel, may be more suitable for patients with primarily pharyngeal motor function impairment or oral and pharyngeal coordinative motor function decline.
Pain‐free bite force in a healthy population: Within‐session test–retest reliability in different sitting positions
Authors: Mitchell Andrew , Heales Luke , Treleaven Julia , Too Brendan , Tyrrell Ryan , Dinsdale Alana 
Published: April 2024

AbstractBackgroundPain‐free bite force (PFBF) is a promising measure to evaluate bite function in temporomandibular disorders (TMDs), yet the reliability of the measure is unknown.ObjectivesEstablish the (1) within‐session test–retest reliability of PFBF in a healthy population for a single and mean of three trials in supported and unsupported sitting; (2) standard error of measurement (SEM) and minimal detectable change (MDC).MethodsThirty healthy participants (n = 15 female, mean [SD] age = 34.4 [11.0] years) completed two sessions (30–60 min apart) comprising three PFBF trials on each side, in both supported and unsupported sitting, to provide data for 60 (30 participants × two sides) test–retest assessments. Test–retest reliability for the first trial and mean of three trials in each position were determined using intraclass correlation coefficients (ICCs), before calculating the corresponding SEM and MDC for males (M) and females (F) respectively.ResultsWithin‐session reliability was considered excellent for a single trial in supported sitting (ICC = 0.85; SEM M/F = 99/84 N; MDC M/F = 275/232 N) and unsupported sitting (ICC = 0.91; SEM M/F = 72/59 N, MDC M/F = 200/163 N), and for a mean of three trials in supported sitting (ICC = 0.89; SEM M/F = 66/79 N, MDC M/F = 182/220 N) and unsupported sitting (ICC = 0.92; SEM M/F = 64/59 N, MDC M/F = 177/164 N).ConclusionSingle and a mean of three trials in supported and unsupported sitting appear reliable methods to measure PFBF in a healthy population. Testing PFBF using a mean of three trials in unsupported sitting appears superior over other methods though due to higher test–retest reliability, and lower SEM and MDC. Future studies should examine the reliability of PFBF in TMD populations.
Characteristics of K‐12 Teachers Considering Leaving Due to COVID‐19 and for Other Reasons
Authors: Dunfee Madeline N. , Bush Heather , Leger Kate A. , Hilbert Timothy J. , Brancato Candace , Haynes Erin N. 
Published: April 2024

ABSTRACTBACKGROUNDThe COVID‐19 pandemic has had drastic effects on K‐12 teachers. Researchers partnered with a teacher advisory board to identify factors associated with K‐12 teachers' consideration of leaving teaching during Fall 2020.METHODSA web‐based survey focused on teachers' working experiences was emailed to school union membership listservs in Indiana, Kentucky, and Ohio. A logistic regression model was developed to identify working conditions associated with teachers considering leaving the profession.RESULTSAmong 5873 K‐12 teachers, 27% (n = 1319) were considering leaving the profession either because of COVID‐19 (10%), for other reasons (6%) or were undecided (11%). Teachers who were midcareer, having taught 6‐10 years, who perceived less supervisor support, whose job duties had changed significantly, who were dissatisfied with the COVID‐19 related decision‐making, who reported poor or fair mental health, and who were mostly or extremely afraid that a household member would get COVID‐19 had higher odds of considering leaving teaching or being undecided about future career plans.IMPLICATIONS FOR SCHOOL HEALTH POLICY, PRACTICE AND EQUITYUnderstanding factors influencing teachers' career decisions will help school leaders improve teacher retention amid challenging circumstances.CONCLUSIONIn this study in 3 midwestern US states, limited supervisor support, significant job duty change, dissatisfaction with COVID‐19‐related decision‐making, poor or fair mental health, and fear that a household member would get COVID‐19 were associated with teachers' consideration of leaving the profession or being undecided about future career plans.
Periodontal granulation tissue – To remove or not to remove, that is the question
Authors: Sam Ye Han , Nibali Luigi , Ghuman Mandeep 
Published: April 2024

AbstractFormation of granulation tissue is a fundamental phase in periodontal wound healing with subsequent maturation leading to regeneration or repair. However, persistently inflamed granulation tissue presents in osseous defects as a result of periodontitis and is routinely disrupted and discarded with non‐surgical and surgical therapy to facilitate wound healing or improve chances of regeneration. Histological assessment suggests that granulation tissue from periodontitis‐affected sites is effectively a chronic inflammatory tissue resulting from impaired wound healing due to persistence of bacterial dysbiotic bioflim. Nevertheless, the immunomodulatory potential and stem cell characteristics in granulation tissue have also raised speculation about the tissue's regenerative potential. This has led to the conception and recent implementation of surgical techniques which preserve granulation tissue with the intention of enhancing innate regenerative potential and improve clinical outcomes. As knowledge of fundamental cellular and molecular functions regulating periodontitis‐affected granulation tissue is still scarce, this review aimed to provide a summary of current understanding of granulation tissue in the context of periodontal wound healing. This may provide new insights into clinical practice related to the management of granulation tissue and stimulate further investigation.
Insomnia and risk of mortality in older adults
Authors: Lawson Yolanda , Wilding Gregory E. , El‐Solh Ali A. 
Published: April 2024

SummaryExisting evidence linking insomnia to all‐cause mortality in older individuals remains inconclusive. We conducted a retrospective study of a large cohort of veterans aged 65–80 years old identified from the Corporate Data Warehouse, a large data repository derived from the Veterans Health Administration integrated medical records. Veterans' enrollees with and without International Classification of Diseases, Ninth and Tenth Revision, codes corresponding to insomnia diagnosis between 1 January 2010 and 30 March 2019 were assessed for eligibility. The primary outcome was all‐cause mortality. A total of 36,269 veterans, 9584 with insomnia and 26,685 without insomnia, were included in the analysis. Baseline mean (SD) age was 72.6 (4.2) years. During a mean follow‐up of 6.0 (2.9) years of the propensity score matched sample, the mortality rate was 34.8 [95% confidence interval: 33.2–36.6] deaths per 1000 person‐years among patients with insomnia compared with 27.8 [95% confidence interval: 26.6–29.1] among patients without insomnia. In a Cox proportional hazards model, insomnia was significantly associated with higher mortality (hazard ratio: 1.39; [95% confidence interval: 1.27–1.52]). Patients with insomnia also had a higher risk of non‐fatal cardiovascular events (hazard ratio: 1.21; [95% confidence interval: 1.06–1.37]). Secondary stratified analyses by sex, race, ethnicity and hypertension showed no evidence of effect modification. A higher risk of mortality (hazard ratio: 1.51; [95% confidence interval: 1.33–1.71]) was observed when depression was present compared with absent (hazard ratio: 1.26; [95% confidence interval: 1.12–1.44]; p = 0.02). In this cohort study, insomnia was associated with increased risk‐adjusted mortality and non‐fatal cardiovascular events in older individuals.