bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Future Agenda for Research on In‐Service Theological Training in Thailand and Beyond
Authors: Winchester Ross , Hovey Kevin , Luetz Johannes M. 
Published: May 2024

AbstractContextualization has featured prominently in missiological research for decades, often alongside concepts such as syncretism and hybridity. Being typically conceived as attempts to transpose and communicate the gospel in words and ways that make sense to people in their local cultural settings, contextualization has been theorized extensively in missiological scholarship. Notwithstanding this longstanding scholarly interest, a dearth of research recognizes in‐service training as a valid expression of contextualization praxis. This article addresses this knowledge gap. Set in the contemporary church context in Thailand, the article explores questions, issues, and trends of current theological training practice, considering future opportunities for indigenous leadership formation. The analysis converges around the central proposition that in‐service training is an under‐recognized strategy for leadership development in Thailand and beyond. Conceptualizing opportunities for future research, the review charts pertinent perspectives and prospects for in‐service training. This article embodies a timely research agenda aimed at sidestepping undue reliance on Western‐dominated hermeneutics while at the same time advocating for indigenous theological training approaches in countries of the majority world.
Enhancing maturity in 3D kidney micro‐tissues through clonogenic cell combinations and endothelial integration
Authors: Abdollahzadeh Fatemeh , Khoshdel‐Rad Niloofar , Bahrehbar Khadijeh , Erfanian Saiedeh , Ezzatizadeh Vahid , Totonchi Mehdi , Moghadasali Reza 
Published: May 2024

AbstractAs an advance laboratory model, three‐dimensional (3D) organoid culture has recently been recruited to study development, physiology and abnormality of kidney tissue. Micro‐tissues derived from primary renal cells are composed of 3D epithelial structures representing the main characteristics of original tissue. In this research, we presented a simple method to isolate mouse renal clonogenic mesenchymal (MLCs) and epithelial‐like cells (ELCs). Then we have done a full characterization of MLCs using flow cytometry for surface markers which showed that more than 93% of cells expressed these markers (Cd44, Cd73 and Cd105). Epithelial and stem/progenitor cell markers characterization also performed for ELC cells and upregulating of these markers observed while mesenchymal markers expression levels were not significantly increased in ELCs. Each of these cells were cultured either alone (ME) or in combination with human umbilical vein endothelial cells (HUVECs) (MEH; with an approximate ratio of 10:5:2) to generate more mature kidney structures. Analysis of 3D MEH renal micro‐tissues (MEHRMs) indicated a significant increase in renal‐specific gene expression including Aqp1 (proximal tubule), Cdh1 (distal tubule), Umod (loop of Henle), Wt1, Podxl and Nphs1 (podocyte markers), compared to those groups without endothelial cells, suggesting greater maturity of the former tissue. Furthermore, ex ovo transplantation showed greater maturation in the constructed 3D kidney.
Can displaced Anguilla marmorata return to their original habitat? Daily tracking study of their homing behavior
Authors: Maeda Tatsuhiko , Hagihara Seishi , Wakiya Ryoshiro , Kimura Shingo 
Published: May 2024

AbstractAnguilla marmorata collected in the Odana River lower reaches were passive integrated transponder‐tagged displaced and released into the upper river reaches (54 up‐transported eels), and eels collected in the upper reaches were tagged and released downstream (52 down‐transported eels). Their movements were detected once per day for 10 days using a portable radio‐frequency identification (RFID) system. The homing rate of the down‐transported eels was 38.9%, compared to 3.7% for the up‐transported eels, suggesting that eels inhabiting upstream areas have relatively high fidelity to their habitats and downstream eels have less fidelity.
The effect of dementia on patterns of healthcare use in older adults with diabetes
Authors: Nothelle Stephanie K. , Kleijwegt Hannah , Bollens‐Lund Evan , Covinsky Kenneth , Ankuda Claire K. 
Published: May 2024

AbstractBackgroundFor persons with diabetes, incidence of dementia has been associated with increased hospitalization; however, little is known about healthcare use preceding and following incident dementia. We describe healthcare utilization in the 3 years pre‐ and post‐incident dementia among older adults with diabetes.MethodsWe used the National Health and Aging Trends Study (NHATS) linked to Medicare fee‐for‐service claims from 2011 to 2018. We included community‐dwelling adults ≥65 years who had diabetes without dementia. We matched older adults with dementia (identified with validated NHATS algorithm) at the year of incident dementia to controls using coarsened exact matching. We examined annual outpatient visits, emergency department (ED) visits, hospitalization, and post‐acute skilled nursing facility (SNF) use 3 years preceding and 3 years following dementia onset.ResultsWe included 195 older adults with diabetes with incident dementia and 1107 controls. Groups had a similar age (81.6 vs 81.7 years) and were 56.4% female. Persons with dementia were more likely to be of minority racial and ethnic groups (26.7% vs 21.3% Black, non‐Hispanic, 15.3% vs 6.7% other race or Hispanic). We observed a larger decrease in outpatient visits among persons with dementia, primarily due to decreasing specialty visits (mean outpatient visits: 3 years pre‐dementia/matching 6.8 (SD 2.6) dementia vs 6.4 (SD 2.6) controls, p < 0.01 to 3 years post‐dementia/matching 4.6 (SD 2.3) dementia vs 5.5 (SD 2.7) controls, p < 0.01). Hospitalization, ED visits, and post‐acute SNF use were higher for persons with dementia and rose in both groups (e.g., ED visits 3 years pre‐dementia/matching 3.9 (SD 5.4) dementia vs 2.2 (SD 4.8) controls, p < 0.001; 3 years post‐dementia/matching 4.5 (SD 4.7) dementia vs 3.5 (SD 6.1) controls, p = 0.04).ConclusionsOlder adults with diabetes with incident dementia have higher rates of acute and post‐acute care use, but decreasing outpatient use over time, primarily due to a decrease in specialty visits.
The effects of carbon emissions trading on profitability and value: Evidence from Korean listed firms
Authors: Park Hyejin , Khue Pham Minh , Lee Jiyoon 
Published: May 2024

AbstractWe examine the effects of environmental regulations on the profitability and value of Korean listed firms, exploiting the first phase of the Korean Emissions Trading System (ETS) as an exogenous shock. While previous studies have mainly focused on environmental regulations in developed countries, often yielding inconclusive results, emerging markets like South Korea remain less explored. Using data on Korean listed firms from 2011 to 2017, we explore the effects of the 2015 Korean ETS on environmental and financial performance in treated firms. We find that treated firms did not reduce their carbon emissions, but their environmental ratings improved. Moreover, the ETS slightly increased profitability but significantly decreased firm value. Treated firms also exhibited a higher systematic risk, indicating that investors account for future carbon risks. In summary, the Korean ETS has not effectively incentivized firms to reduce emissions and has diminished their long‐term value.
Water rights trading and corporate productivity: Evidence from a quasi‐natural experiment of China's pilot policy
Authors: Liu Duan , Yu Nizhou , Wan Hong , Ou Jinghua , Yao Shujie , Wang Qiuhong 
Published: May 2024

AbstractThe economic consequences of water efficiency that results from water policies remains controversial. Studies on how water rights trading (WRT), which allocates water resources in and across industries, influences corporate efficiency can reveal the behavioral response of market participants to increase water efficiency. Considering the WRT pilot implemented in 2014 as a quasi‐natural experiment, we adopt the difference‐in‐difference‐in‐differences method to evaluate its impact on corporate total factor productivity (TFP). Our findings show that WRT significantly stimulates the TFP of firms with high water costs. This effect is achieved by promoting water‐related green innovation and optimizing resource allocation instead of alleviating corporate risks. Furthermore, the impact of WRT is more pronounced in areas with lower levels of water endowment and market development. The research findings have strikingly important policy implications regarding water management in China through WRT.
Do effervescent vitamin tablets affect the surface roughness, microhardness, and color of human enamel and contemporary composite resins?
Authors: Sozen Yanik Irem , Kesim Betül , Ersu Bahadır , Koc Vural Uzay 
Published: May 2024

AbstractPurposeTo compare the impact of four effervescent vitamin tablets on the surface roughness, microhardness, and color of human enamel and contemporary composite resins.Material and MethodsSixty enamel and a total of 240 anterior (Gradia Direct Anterior), posterior (Gradia Direct Posterior), and universal composite resin (Filtek Ultimate) specimens (n = 60 per group) were fabricated. Each group was subdivided into five subgroups (n = 12, per subgroup). The specimens were subsequently immersed in YOUPLUS, Redoxon, Sunlife Immuvit, and Sambucol effervescent vitamin solutions for 2 min per day over 30 days. Distilled water was used as control. Subsequently, surface roughness (Ra) was detected using a profilometer, and microhardness (VHN) was measured using a microhardness tester. A spectrophotometer device was used to record the L,a,b color coordinates of the specimens after 24 h, 7 days, and 30 days, and the color changes (ΔE00) of the groups were calculated. The data were analyzed by ANOVA, two‐way ANOVA, Kruskal‐Wallis, Levene's, and Fisher's least significant difference (LSD) tests (p < 0.05). SEM analysis was conducted on one randomly selected specimen per group (×1000).ResultsIn terms of surface roughness, material X vitamin interactions were found significant (p < 0.05). The increase in Ra from 24 h to 30 days was found significant (p < 0.05) except for Gradia Direct Anterior X Redoxon, Sunlife Immuvit and Sambucol, Filtek Ultimate X Sunlife Immuvit and Sambucol, and all control groups. Ra changes were also concluded by SEM. Regarding VHNs, material X vitamin interactions were significant (p < 0.005), except for all Filtek Ultimate subgroups. The changes in VHNs of the groups from 24 h to 30 days were significant for all enamel and Gradia Direct Anterior X YOUPLUS, Gradia Posterior X YOUPLUS, Sunlife Immuvit, and Sambucol groups (p < 0.05). In terms of ΔE00, significant differences were observed between the 7 days and 30 days in the enamel (p = 0.047), Gradia Direct Anterior (p = 0.019), and Gradia Direct Posterior groups (p = 0.038).ConclusionsDaily consumption of effervescent vitamin tablets can increase surface roughness, decrease microhardness, and influence the color of human enamel and contemporary anterior, posterior, and universal composite resins after a 30‐day period.
Exploring current and emerging therapies for porphyrias
Authors: Jericó Daniel , Córdoba Karol M. , Urigo Francesco , Enríquez de Salamanca Rafael , Anderson Karl E. , Deybach Jean‐Charles , Ávila Matías A. , Fontanellas Antonio 
Published: May 2024

AbstractPorphyrias are rare, mostly inherited disorders resulting from altered activity of specific enzymes in the haem synthesis pathway that lead to accumulation of pathway intermediates. Photocutaneous symptoms occur when excess amounts of photoreactive porphyrins circulate in the blood to the skin, whereas increases in potentially neurotoxic porphyrin precursors are associated with neurovisceral symptoms. Current therapies are suboptimal and their mechanisms are not well established. As described here, emerging therapies address underlying disease mechanisms by introducing a gene, RNA or other specific molecule with the potential to cure or slow progression of the disease. Recent progress in nanotechnology and nanoscience, particularly regarding particle design and formulation, is expanding disease targets. More secure and efficient drug delivery systems have extended our toolbox for transferring specific molecules, especially into hepatocytes, and led to proof‐of‐concept studies in animal models. Repurposing existing drugs as molecular chaperones or haem synthesis inhibitors is also promising. This review summarizes key examples of these emerging therapeutic approaches and their application for hepatic and erythropoietic porphyrias.
The clinical management of porphyria cutanea tarda: An update
Authors: Sarkany R. P. E. , Phillips J. D. 
Published: May 2024

AbstractPorphyria cutanea tarda (PCT) is the commonest of the porphyrias (Semin Liver Dis 1998;18:67). It often occurs secondary to an underlying internal disorder, has significant impacts on liver health and longevity, and is a treatable disease. Thus, for the clinician, recognising the disease to make the correct diagnosis, identifying causative underlying diseases, and treating the porphyria and its complications, are crucial. Although reviews on the management of PCT have been written, there have recently been significant advances in the understanding of the factors predisposing to the disease, and of its wider health impacts. This review aims to help the clinician to diagnose and manage patients with PCT, with an emphasis on the impact of recent advances on clinical management.
Impact of Matrix Gel Variations on Primary Culture of Microvascular Endothelial Cell Function
Authors: Burboa Pía C. , Corrêa‐Velloso Juliana C. , Arriagada Cecilia , Thomas Andrew P. , Durán Walter N. , Lillo Mauricio A. 
Published: May 2024

AbstractObjectiveThe endothelium regulates crucial aspects of vascular function, including hemostasis, vasomotor tone, proliferation, immune cell adhesion, and microvascular permeability. Endothelial cells (ECs), especially in arterioles, are pivotal for flow distribution and peripheral resistance regulation. Investigating vascular endothelium physiology, particularly in microvascular ECs, demands precise isolation and culturing techniques.MethodsFreshly isolated ECs are vital for examining protein expression, ion channel behavior, and calcium dynamics. Establishing primary endothelial cell cultures is crucial for unraveling vascular functions and understanding intact microvessel endothelium roles. Despite the significance, detailed protocols and comparisons with intact vessels are scarce in microvascular research. We developed a reproducible method to isolate microvascular ECs, assessing substrate influence by cultivating cells on fibronectin and gelatin matrix gels. This comparative approach enhances our understanding of microvascular endothelial cell biology.ResultsMicrovascular mesenteric ECs expressed key markers (VE‐cadherin and eNOS) in both matrix gels, confirming cell culture purity. Under uncoated conditions, ECs were undetected, whereas proteins linked to smooth muscle cells and fibroblasts were evident.Examining endothelial cell (EC) physiological dynamics on distinct matrix substrates revealed comparable cell length, shape, and Ca2+ elevations in both male and female ECs on gelatin and fibronectin matrix gels. Gelatin‐cultured ECs exhibited analogous membrane potential responses to acetylcholine (ACh) or adenosine triphosphate (ATP), contrasting with their fibronectin‐cultured counterparts. In the absence of stimulation, fibronectin‐cultured ECs displayed a more depolarized resting membrane potential than gelatin‐cultured ECs.ConclusionsGelatin‐cultured ECs demonstrated electrical behaviors akin to intact endothelium from mouse mesenteric arteries, thus advancing our understanding of endothelial cell behavior within diverse microenvironments.
Representing the nation in Citizenship in an Independent Scotland: Compromised inclusion?
Authors: Bond Ross 
Published: May 2024

AbstractThis paper analyses how Citizenship in an Independent Scotland (CIS)—published by the Scottish Government as part of a ‘prospectus for an independent Scotland’—discursively represents the Scottish nation in the context of establishing who should be eligible to be a member of that nation. I relate CIS to the historical and contemporary determination of British citizenship and to evidence concerning popular conceptions of citizenship and national belonging in Scotland. I argue that while CIS reflects nation‐building through an attempt to rhetorically differentiate Scotland from Britain, it also reflects the influence that the evolution of British citizenship has on proposed post‐independence Scottish citizenship. I also evaluate CIS's stress on ‘inclusion’, consistent with its representation of Scotland as an ‘inclusive’ nation. I conclude that the proposals may be described as compromised inclusion and that the reasons for this are likely to be common to similar aspirational secessionist proposals in sub‐state nations.
Feasibility, Reliability, and Effectiveness of Oral cancer screening in South Asia and Southeast Asian countries: A systematic review and Meta‐analysis
Authors: Gurushanth Keerthi , Sunny Sumsum P. , Kuriakose Moni Abraham , Birur Praveen N. 
Published: May 2024

AbstractObjectivesThe incidence of oral cancer is significantly high in South Asia and Southeast Asia. Organized screening is an effective approach to early detection. The aim of this systematic review and meta‐analysis was to evaluate the reliability, diagnostic accuracy, and effectiveness of visual oral screening by community health workers (CHWs) in identifying oral cancer/oral potentially malignant disorders (OPMDs) in this region.Materials and MethodsWe conducted a bibliographic search in PubMed, Scopus, the gray literature of Google Scholar, ProQuest dissertations, and additional manual searches. Twelve articles were included for qualitative synthesis and six for meta‐analysis. Pooled sensitivity, specificity, diagnostic odds ratio (DOR), and forest plot analysis were performed.ResultsMeta‐analysis showed CHWs identified 8% (n = 6365) as suspicious and 92% (n = 74,140) as normal. The diagnostic accuracy of visual oral screening by CHWs showed a sensitivity of 75% (CI: 74–76) and specificity of 97% (CI: 97–97) in the detection of OPMDs/oral cancer. Forest plots were obtained using a random effects model (DOR: 24.52 (CI: 22.65–26.55)) and SAUC: 0.96 (SE = 0.05).ConclusionsOral visual examination by trained CHWs can be utilized for community screenings to detect oral cancer early. This approach can be used in primary healthcare to triage patients for further referral and management.
Risk quantification as an epidemiological analysis strategy: Analysis and application to bud rot in oil palm
Authors: Ramírez‐Gil Joaquín Guillermo , Rivera‐Lozano Carlos Mauricio , Tapiero Aníbal L. 
Published: May 2024

AbstractBud rot (BR), caused by Phytophthora palmivora, limits growth and development of oil palms in the American continent, particularly in Colombia. Due to the absence of systematic epidemiological analyses and determination of risk factors associated with BR, this study aimed to employ deterministic mathematical models and frequentist and Bayesian statistical methods to quantify the genetic response and edaphoclimatic variables as risk indicators of BR. From 2011 to 2014, the severity of BR in oil palm crops was recorded monthly in two locations: Tumaco (hot spot) and Villavicencio (cold spot), determining the edaphoclimatic variables at each site. Using the area under the disease progress stairs curve, temporal models were applied to determine the rate of disease development (R0) to quantify risk at locality and genotype levels. Subsequently, the observed intensity and severity levels of BR were adjusted to models such as survival curves, Cox proportional hazard risk and transition probabilities, or Markov states, with the aim of quantifying and characterizing risk factors associated with genotype and edaphoclimatic variables at each location. The risk in Tumaco was three times higher than in Villavicencio, and the R0 values were differential by genotype, with Tenera more susceptible than Hybrids. Moreover, the risk of BR increased when periods of 2–3 months occurred with successive instances of precipitation and relative humidity greater than 150 mm/month and 90%, respectively, and when manganese and zinc levels were below optimal. This approach allowed us to characterize epidemiological factors that cause plant diseases, allowing quantification of the risk of BR.
Early prognostic markers to predict unsuccessful pregnancy in dairy cattle
Authors: Yokus Beran , Takci Abdurrahman , Ercan Nazli , Em Bernan , Uysal Ersin 
Published: May 2024

AbstractThis study aimed to investigate maternal serum levels of some angiogenic factors and certain proteins in dairy cattle for (1) early prediction of unsuccessful fertilization and (2) early detection of possible pregnancy failures (early EM) after positive insemination Serum samples were collected from the same cattle at three distinct time points: 30 days before artificial insemination (B‐AI), on the day of artificial insemination (AI), and 30 days after artificial insemination (A‐AI). As a result of the pregnancy examination, the cows were divided into two main groups according to whether they were pregnant. The results showed that leucyl/cystinyl aminopeptidase (LNPEP) concentration was significantly decreased B‐AI and Secreted frizzled‐related proteins (SFRP‐3), Vascular Endothelial Growth Factor (VEGF) and LNPEP levels were significantly decreased on day of AI, while PRL level was increased, and these data have prognostic significance as early indicator of the risk of potentially failed pregnancy. Additionally, a significant decrease in LNPEP, SFRP3, and VEGF levels, along with an increase in PRL levels was also observed in A‐AI. These results suggest that these biomarkers can be used as a screening test to monitor the course of pregnancy. There were no significant differences in serum levels of Insulin‐Like Growth Factor 2 (IGF‐2), Tissue inhibitors of metalloproteinases (TIMP‐1), angiopoietin (ANG), Endoglin (ENG), Fibroblast growth factor (FGF), Inhibine‐A (INH‐A) and Transforming growth factors‐β1 (TGF‐β1) between the evaluated periods neither unsuccessful nor the successful pregnancy groups. This is the first study reporting that the maternal serum levels of LNPEP, SFRP3, VEGF, and PRL have important roles in pregnancy success and may indicate whether insemination outcome will be successful B‐AI and predict the risk of unsuccessful pregnancy after AI in dairy cattle. The increase in such studies will allow the development of more specific, practical, and applicable markers.
Inversion of the two‐data circular Radon transform centered on a curve on C(R2)${\cal C}(\mathbf {R}^2)$
Authors: Aramyan Rafik 
Published: May 2024

AbstractMore often, in the mathematical literature, the injectivity of the spherical Radon transform (SRT) for compactly supported functions is considered. In this article, an additional condition, for the reconstruction of an unknown function (the support can be noncompact) using the circular Radon transform (CRT) over circles centered on a smooth simple curve is found. It is proved that this problem is equivalent to the injectivity of a so‐called two‐data CRT over circles centered on a smooth curve (can be a segment). Also, we present an inversion formula of the transform that uses the local data of the circular integrals to reconstruct the unknown function. Such inversions are the mathematical base of modern modalities of imaging, such as thermo‐ and photoacoustic tomography and radar imaging, and have theoretical significance.