bluuebunny/crossref_metadata_2025_split huggingface dataset:
Development and validation of a quantitative minilab system for quality evaluation of selected medicines: Albendazole, arthemether-lumefantrine combination (Co-artem®), and mebendazole finished pharmaceutical products
Authors: Hasen Gemmechu , Birhane Worku , Suleman Sultan , Ashenef Ayenew 
Published: April 2024

AbstractThe current technologies for substandard and counterfeit drug detection are either too expensive for low-resource settings or only provide qualitative or semi-quantitative results. GPHF minilab™ is one of them based on thin layer chromatography(TLC) principles with a semi-quantitative capability by visual observation of the spot area and intensity for medicine quality analysis. Thus, its use as a quality control tool for pharmaceutical products has limitations as spot area and intensity visual observation by the naked eye highly varies from analyst to analyst. As such, in this study, the semi-quantitative technique has been transferred to a quantitative approach by capturing the developed TLC plate image using an Android-based mobile phone inside a simple carton box. Then, the spot area was quantified using justTLC software. The quantitative results were compared with the-high performance liquid chromatography (HPLC) method as the golden standard. Accordingly, linearity was observed in the assayed range (80–120% label claim), and the correlation coefficients found were (R2 = 0.958, 0.997, 0.941, and 0.956 for Albendazole, Mebendazole, Artemether, and Lumefantrine, respectively.). The values are satisfactory. The %RSDs found were less than 2% for all drugs [intraday (n = 6) (RSD = 1.17, 1.61, 1.87, and 1.64), and interday (n = 18) (RSD = 1.16, 0.72, 1.12, and 1.18) for Artemether, Lumefantrine, Mebendazole, and Albendazole, respectively]. Moreover, comparisons of results obtained from the sophisticated CAMAG UV cabinet (R2 =0.991, 0.971, 0.946, and 0.967) and the developed simple carton box (R2 = 0.958, 0.997, 0.941, and 0.956) for Albendazole, Mebendazole, Artemether, and Lumefantrine, respectively. The values are comparable and reveal the accuracy of the method. Robustness testings' that were performed under different altered conditions revealed the robustness of the method (RSD less than 2% for all factors). Additionally the deviations from the golden HPLC results were on average −8.62% for albendazole, −3.79% for artemether, and −4.52% for lumefantrine samples. The developed method shows a satisfactory performance capability to utilize the GPHF minilab™ as a quantitative technique for medicine quality control purposes. It will be a very useful tool in a resource-limited setting. The target method profile, which encompasses a simple, low-cost, linear, precise, robust, accurate, and quantitative GPHF minilab™ system, was obtained for Albendazole, Mebendazole, and Arthemeter lumefantine combinations (Co-artem). The proposed method was successfully applied to analyze the content of the marketed medicines in the above mentioned tablets and offered acceptable deviations from the golden HPLC method. Automation of quantitative GPHF minilab™ was highly recommended to enhance the appropriateness and use of this system.
Validation of HPLC-DAD method for analysis of paracetamol and potassium sorbate in liquid oral formulations and its application to forced degradation study
Authors: Mikulić Mira , Sazdanić Darija , Kladar Nebojša , Radulović Jovana , Srđenović Čonić Branislava , Atanacković Krstonošić Milica 
Published: April 2024

AbstractDue to the frequent use of paracetamol formulations, it is useful to develop an analytical technique for the determination of intact paracetamol in presence of other drugs and excipients or the degradation products. In this study, a simple, isocratic, fast, specific, accurate and precise stability-indicating high performance liquid chromatography (HPLC) method has been developed and validated for simultaneous quantitative determination of paracetamol (PCM) and potassium sorbate (PS) in oral liquid formulations. The chromatographic separation was achieved on Zorbax SB C18 column (150 × 4.6 mm, 5 µm) with Zorbax SB C18 precolumn (12.5 × 4.6 mm, 5 µm) using distilled water pH 2 with ortho-phosphoric acid and acetonitrile (70:30, v/v) as a mobile phase, and UV detection at 235 nm. The temperature of the column was kept constant at 25 °C. The method was validated according to International Conference on harmonization (ICH) guidelines. The method demonstrated excellent linearity, with a correlation coefficient of 0.9996 and 0.9998 for PCM and PS, respectively, over the concentration ranges of 10–600 μg mL−1 (PCM) and 6–500 μg mL−1 (PS). The retention time was found to be 1.98 and 4.86 min for PCM and PS, respectively. Oral liquid formulation samples were subjected to various stress conditions (acidic and alkaline hydrolysis, as well as oxidative, heat and photolytic degradation) for the purpose of forced degradation study. The major degradation of paracetamol was achieved in acidic and basic stress conditions, while thermal and photolytic degradation generally had the least influence. On the other hand, potassium sorbate was highly susceptible to photolytic degradation. It was also shown that the formulation has strong influence on stability of tested compounds. Forced degradation studies demonstrated the stability-indicating power of the method and can be used to assess the stability of paracetamol and potassium sorbate in oral liquid formulations.
Regeneration design of mining brownfield based on nature-based solutions
Authors: Tu Kangwei , Niu Yilin , Reith Andras 
Published: April 2024

AbstractMining industry once was a strong contributor to the economic development of cities and created economic benefits for human beings, but ecological problems are increasing day by day. This study takes the quarry in Nagykovacsi, Hungary as an example, and through comprehensive evaluation of the site, utilizes nature-based solutions to carry out the design practice of seeking new development vitality and opportunities for the brownfield site after mining. Finally, it summarizes the ecological remediation concepts and strategies suitable for mining brownfield sites, and contributes to the reuse of urban land space and the creation of a favourable ecological environment.
Functional movement screen score to predict injury risk of sports students: a review of foot shape and body mass index
Authors: Anam Khoiril , Setiowati Anies , Indardi Nanang , Irawan Fajar Awang , Pavlović Ratko , Susanto Nugroho , Aditia Eva Ayu , Muhibbi Muhammad , Setyawan Hendra 
Published: April 2024

Background and Study Aim. Excessive physical activity poses a risk of injury, particularly when coupled with high exercise intensity. Factors such as Body Mass Index (BMI) and foot morphology may contribute to this risk. This study seeks to evaluate the relationship between BMI, foot shape, and the likelihood of injury among sports students.
Material and Methods. A total of 119 sports students, comprising 33 females and 86 males, participated in this study. Purposive sampling was employed to select participants. BMI was determined using height and weight measurements, while foot shape was assessed through footprint measurements. The Functional Movement Screening (FMS) instrument, encompassing 7 movements: Deep Squats, Hurdle Steps, Inline Lunges, Shoulder Mobility, Active Straight Leg Raises, Trunk Stability Push-ups, and Rotary Stability, was utilized to assess injury risk. Data analysis was conducted using Microsoft Excel and IBM SPSS v.25.0, employing descriptive statistics.
Results. Based on data analysis, the FMS value in females shows a mean of 18.7 and a standard deviation of 1.21. At the same time, the FMS value in males shows 18.5 and a standard deviation of 1.41. BMI values in females showed a mean of 21.6 and a standard deviation of 3.03. At the same time, BMI values in males showed a mean of 22.9 and a standard deviation of 4.62. The results were that all FMS scores were ≥14. While of BMI measurements, some samples obtained ˂18 kg/m² and ˃30kg/m². BMI measurements according to gender were mainly in the normal weight category. However, those who fall into the obesity category are primarily males. With the results of measuring the foot's shape, the percentage of flat feet is only 0.84% in females and 7.59 in males, while the rest of the sample has a normal foot shape.
Conclusions. Individuals with a BMI in the overweight to obese category are more susceptible to high-category injuries, likely due to limited motion range. However, the study did not find evidence linking flat foot shape to high-category injury risk. This inability to establish a correlation may be attributed to the predominantly normal foot shape observed in the sample, resulting in a prediction of low-category injury risk.
Parental ideologies in multilingual Family Language Policies in the Basque Autonomous Community (Spain)
Authors: Garcia-Ruiz Maite , Manterola Ibon , Ortega Ane 
Published: April 2024

The study of Family Language Policy (FLP) with a minority language has most often focused on the policies on the minority language within the framework of the hegemonic position of a majority language. This article, however, takes the view that a multilingual approach is needed to better understand parental decisions in their FLPs when a foreign language is also present in the education of their children. The data presented in this article is based on a PhD research project which studies the FLPs of Basque parents living in a mostly Spanish-speaking area of the Basque Autonomous Community (BAC) and whose children attend a Basque-medium school with early introduction of English as the L3. Results show that their ideological positioning in relation to Basque, the different values attached to each of their children’s languages, as well as their ideas about multilingualism determine to a great extent their FLPs. Whilst all parents support Basque and positively value learning English, some differences have been identified: Basque is prioritised above all by the most activist parents, who establish an iron-cast hierarchy among languages; English has been found to have a clear value and function, but its place in this hierarchy varies; and in all cases, Spanish is considered to be guaranteed and not requiring special ad hoc strategies. The study confirms the ideological positioning in relation to the minority language as a key factor in minority language FLPs, but also shows the impact of ideas about multilingual upbringing in their decisions, their expectations, and the degree of satisfaction or frustration with results.
Preliminary Study about Desalinated Water and Alkalinity
Authors: Benouali Djillali , Benhammadi Samia , Kherici Samira , Kadri Sofiene 
Published: April 2024

One of the promising techniques to meet the needs of growing population for drinking water is the desalination of seawater and brackish water. Desalination is carried out mainly by multi-stage flash (MSF) or reverse osmosis (RO). The water obtained by desalination (RO, MSF and others processes) can be used as drinking water, after the reconstruction of its salts content (blending). However, reverse osmosis can produce, under certain pressure, flow and feed water quality, water similar in their physic-chemical properties as conductivity, Total Dissolved Salts (TDS) to bottled natural water, widely marketed. In any case, it would be interesting to be able to distinguish reverse osmosis water from sprig water. In this context, the determination of the alkalinity (TA) and the pH and subsequently the verification of the correlation between these two parameters are proposed in this work. Also, a comparison of the physic-chemical quality of drinking water supplied by MSF and RO is made. The parameters, pH, conductivity, TA, TDS and hardness (TH) were discussed. These two types of water are practically identical by physic-chemical quality since the blending is done in the same way by injecting CO2/Calcium carbonate. However, reverse osmosis water contains more sodium chloride because of the low retention rate of membranes against this ion.
Kredyty zagrożone NPL oraz odpisy na straty kredytowe w sektorze bankowym
Authors: Czechowska Iwona Dorota , Lipiński Czesław , Stawska Joanna , Stępińska Joanna , Zatoń Wojciech , Borys Marcin 
Published: April 2024

Działalność kredytowa to obszar działalności bankowej, stanowiący główne źródło przychodów, powiązany z ryzykiem kredytowym, którego materializacja generuje straty dla wyniku finansowego i bazy kapitałowej pojedynczych instytucji kredytowych oraz stabilności systemu bankowego i finansowania gospodarki.
Celem opracowania jest przedstawienie, ocena i prognozowanie strat kredytowych w sektorze bankowym w Polsce, w kontekście identyfikacji prawidłowości i trendów należności kredytowych, oraz zależności przyczynowo-skutkowych między wynikiem z tytułu oczekiwanych strat kredytowych a sytuacją gospodarczą.
Strata kredytowa wg MSSF 9 stanowi różnicę między wszystkimi, wynikającymi z umowy kredytowej przepływami pieniężnymi należnymi jednostce i wszystkimi przepływami pieniężnymi, które jednostka spodziewa się otrzymać, dyskontowaną według pierwotnej efektywnej stopy procentowej. Straty kredytowe powstają w sytuacjach pogorszenia zdolności kredytowej oraz czynników po stronie instytucji kredytowej.
Jako metodę badawczą zastosowano model prognostyczny, poprzedzony prezentacją czynników determinujących wynik ECL, a także wyznaczaniem wyniku ECL. Zidentyfikowano istotne zmienne makroekonomiczne a także określono założenia dla uwarunkowań makroekonomicznych w modelach oczekiwanych strat kredytowych. Przeprowadzona analiza wskazuje, że sektor bankowy dość skutecznie kontroluje poziom powstających strat kredytowych, na co wskazuje malejący trend wskaźnika NPL i stosunkowo łagodne przejście okresu związanego z pandemią COVID-19. Przyczynia się do tego ostrożna polityka kredytowa i zarządzanie należnościami z utratą wartości. Należy jednak zauważyć, że gwałtowne pogorszenie sytuacji makroekonomicznej w krótkim czasie będzie stanowić duży problem dla sektora bankowego.
Avaliação de séries históricas de precipitação para captação de águas pluviais no município de Teófilo Otoni/MG
Authors: Magalhães Thalissa Oliveira Pires , Dalmo Francisco César 
Published: April 2024

This study aimed to evaluate the linear correlation between data from four rainfall stations for the design of a rainwater harvesting system for non-potable purposes in a municipal public school in Teófilo Otoni, MG. First, a cartographic study was carried out using a geographic information system environment in order to generate a map with the rainfall stations and the school where the collection system was designed. Next, an attempt was made to assess the availability of data present at the stations and compare them using linear regression. Finally, the design of the rainwater harvesting system for the school was carried out. The results of the linear correlation indicate that the four stations can be used in the sizing of the system. Finally, the implementation of the system can contribute to the reduction of water consumption and, consequently, financial expenses.
Elemen Fasad Bangunan Pembentuk Karakter Koridor Jalan Ahmad Yani Garut Berdasar Preferensi Masyarakat
Authors: Sudaryanto Anto , Winandari Maria Immaculata Ririk 
Published: April 2024

<p><em>The corridor of Jalan Ahmad Yani, as the main street of Garut Regency, is part of Garut Heritage sites. As a historical place, the area’s character becomes an important part. This study aims to find the building facade elements that formed the character of the Jalan Ahmad Yani corridor. Quantitative method with Conjoint is used to analyze and interpret data. Respondents consist of 20 architects that live in Garut. Massing shape, roof shape, walls, door and window openings, ornaments or billboards, texture, and color are the variables studied. The study found that the facade elements that are considered important in forming the character of the corridor, are geometric shapes, triangular roof shapes, mixed walls of solid and transparent, smooth textured, and calm colors, the shape of window openings pointing vertically and doors that balanced in the façade composition, and ornaments or billboards as part of the building façade composition.</em></p>
Anteromedial Cortical Support in Reduction of Trochanteric Hip Fractures
Authors: Mao Wei , Liu Chen-Dong , Chang Shi-Min , Yang Ao-Lei , Hong Choon Chiet 
Published: April 2024

Update
This article was updated on July 10, 2024 because of a previous error. Specifically, on pages 1009 through 1018, the running heads that had previously read “Preoperative Lab Values Predicting Periprosthetic Joint Infection in Morbidly Obese Patients” now read “Anteromedial Cortical Support in Reduction of Trochanteric Hip Fractures.”
An erratum has been published: J Bone Joint Surg Am. 2024 Aug 21;106(16):e36.

➤ The concept of anteromedial cortical support (AMCS) serves as valuable guidance for the intraoperative reduction of trochanteric hip fractures.➤ Positive medial cortical support (MCS) and positive or neutral anterior cortical support (ACS) are desirable. Some evidence has suggested that positive MCS is potentially superior to neutral MCS.➤ Experimental studies underscore the vital importance of the anteromedial wall and reveal why positive MCS potentially outperforms neutral MCS.➤ Incorporating the AMCS concept, the Chang reduction quality criteria (CRQC) are a reliable alternative approach to evaluate the reduction quality of trochanteric hip fractures.
Five-Year Mortality Rates Following Elective Shoulder Arthroplasty and Shoulder Arthroplasty for Fracture in Patients Over Age 65
Authors: Khan Adam Z. , Zhang Xiaoran , Macarayan Erlyn , Best Matthew J. , Fedorka Catherine J. , Haas Derek A. , Armstrong April D. , Jawa Andrew , O’Donnell Evan A. , Simon Jason E. , Wagner Eric R. , Malik Momin , Gottschalk Michael B. , Updegrove Gary F. , Warner Jon J.P. , Srikumaran Uma , Abboud Joseph A. ,   and the Avant-garde Health and Codman Shoulder Society Value-Based Care Group
Published: April 2024

Background:
To effectively counsel patients prior to shoulder arthroplasty, surgeons should understand the overall life trajectory and life expectancy of patients in the context of the patient’s shoulder pathology and medical comorbidities. Such an understanding can influence both operative and nonoperative decision-making and implant choices. This study evaluated 5-year mortality following shoulder arthroplasty in patients ≥65 years old and identified associated risk factors.

Methods:
We utilized Centers for Medicare & Medicaid Services Fee-for-Service inpatient and outpatient claims data to investigate the 5-year mortality rate following shoulder arthroplasty procedures performed from 2014 to 2016. The impact of patient demographics, including fracture diagnosis, year fixed effects, and state fixed effects; patient comorbidities; and hospital-level characteristics on 5-year mortality rates were assessed with use of a Cox proportional hazards regression model. A p value of <0.05 was considered significant.

Results:
A total of 108,667 shoulder arthroplasty cases (96,104 nonfracture and 12,563 fracture) were examined. The cohort was 62.7% female and 5.8% non-White and had a mean age at surgery of 74.3 years. The mean 5-year mortality rate was 16.6% across all shoulder arthroplasty cases, 14.9% for nonfracture cases, and 29.9% for fracture cases. The trend toward higher mortality in the fracture group compared with the nonfracture group was sustained throughout the 5-year postoperative period, with a fracture diagnosis being associated with a hazard ratio of 1.63 for mortality (p < 0.001). Medical comorbidities were associated with an increased risk of mortality, with liver disease bearing the highest hazard ratio (3.07; p < 0.001), followed by chronic kidney disease (2.59; p < 0.001), chronic obstructive pulmonary disease (1.92; p < 0.001), and congestive heart failure (1.90; p < 0.001).

Conclusions:
The mean 5-year mortality following shoulder arthroplasty was 16.6%. Patients with a fracture diagnosis had a significantly higher 5-year mortality risk (29.9%) than those with a nonfracture diagnosis (14.9%). Medical comorbidities had the greatest impact on mortality risk, with chronic liver and kidney disease being the most noteworthy. This novel longer-term data can help with patient education and risk stratification prior to undergoing shoulder replacement.

Level of Evidence:
Therapeutic Level III. See Instructions for Authors for a complete description of levels of evidence.
Expectedness of Human Comfort Index of Heat Wave Events over Bangladesh Using WRF-ARW and RayMan-Pro Model
Authors: Rahman Flora , Akhter Md. Abdullah Elias , Mallik Muhammad Abul Kalam , Matzarakis Andreas 
Published: April 2024

Abstract

Abstract:
High-resolution Weather Research and Forecasting (WRF-ARW V4.4.2) model is used for the simulation of heat wave events that occurred during 19–26 May 2017, 12–19 May 2020 and 19–26 May 2021. So, an attempt has been made for simulating the extreme temperature conditions over Bangladesh using the WRF model and then an effort has been done to construct the Human Comfort Index (HCI) by the RayMan-Pro model. National Centers for Environmental Prediction (NCAR) final reanalysis (FNL) data are used as initial and lateral boundary conditions (LBCs) which are updated at three hourly intervals. A single domain with a 10 km horizontal resolution along with a vertical level of up to 100 hPa is used. The WRF model runs for 168 hr. which is treated as 7 days with Kesler microphysics (MP) schemes, YSU PBL schemes and Kain-Fritsch (KF) cumulus schemes, Rapid Radiative Transfer Model for longwave radiation and Dudhia scheme for short wave radiation. In this study, HW events are simulated using WRF model and thermos-physiologically human comfort indexes (HCI) such as Physiologically Equivalent Temperature (PET), and Standard Effective Temperature (SET*) are analyzed by RayMan-Pro model at 34 stations in Bangladesh during pre-monsoon season. In this research, an attempt has also been made to study the HW scenario, its characteristics and predictability for anticipatory actions over Bangladesh. The maximum observed (simulated) Temperatures (T2) of Khulna, Satkhira, Mongla, Rajshahi and Jashore stations are close to each other so, the WRF model performance is very well for predicting T2. The maximum observed (simulated) PET and SET* are obtained more than 41 ̊C which is extremely hot conditions so, to compute HCI over Bangladesh, the RayMan-Pro model performs real scenario of adequately.
Comparison of Reproductive Outcomes after Laparoscopic Tubal Anastomosis Using Conventional (Non-Barbed) Sutures versus Barbed Sutures
Authors: Karadag Ceyda , Karadag Burak 
Published: April 2024

Abstract

Purpose
Our aim is to compare reproductive outcomes after laparoscopic tubal anastomosis using conventional (non-barbed) sutures and barbed sutures.
Methods
This retrospective cohort study was conducted at Antalya Training and Research Hospital between January 2016 and December 2021. A total of 39 patients who underwent laparoscopic tubal anastomosis were divided into two groups: the Vicryl group (16 women) using 5 − 0 polyglactin sutures, and the V-Loc group (23 women) using 5 − 0 unidirectional barbed sutures. Demographic data, operation time, success of reversal operation, pregnancy rates, and other factors were compared between the two groups.
Results
The operation time was significantly shorter in the V-Loc group (55.8 ± 7.33 minutes) compared to the Vicryl group (108.7 ± 17.27 minutes) (p = 0.001). The overall pregnancy rate was higher in the V-Loc group (87%) than in the Vicryl group (56.3%) (p = 0.037). The rate of intrauterine pregnancy was also significantly higher in the V-Loc group (p = 0.041). The time interval from surgery to pregnancy was not significantly different between the groups.
Conclusion
The use of barbed sutures in laparoscopic tubal anastomosis can result in shorter operation times and better reproductive outcomes compared to conventional sutures.