bluuebunny/crossref_metadata_2025_split huggingface dataset:
Creating sustainable relationships using the strengths, opportunities, aspirations and results framework, trust, and environmentalism: a research‐based case study
Authors: Sprangel Joseph , Stavros Jacqueline , Cole Matthew 
Published: February 2011

New forms of organization development are moving from a classical diagnostic perspective to a dialogic perspective. This move includes a focus on exploring positive states of organizing, shared aspirations, and the design of preferred futures as key outcomes of a strategic change process. Training and development that applies the elements of the strengths, opportunities, aspirations and results (SOAR) framework allows for stakeholders to engage in a dialogue that represents the whole system, and builds trust and environmental management systems that can positively impact supplier performance. In this study, we examined the interrelationship between the SOAR framework, trust, environmental management systems, and supplier performance in respect of 71 program managers and customers from the Hass TCM Group, the largest chemical management services provider in North America.Hypothesis testing was carried out using correlation analysis, multiple linear regression, correlation analysis and Sobel's test for mediation. Our results support a combined framework in which the SOAR framework can be used to build trust and pro‐environmental behaviors to train suppliers to develop collaborative relationships with customers.
Risk of Circuit Infection in Septic Patients on Extracorporeal Membrane Oxygenation: A Preliminary Study
Authors: Müller Thomas , Lubnow Matthias , Philipp Alois , Schneider‐Brachert Wulf , Camboni Daniele , Schmid Christof , Lehle Karla 
Published: February 2011

AbstractExtracorporeal membrane oxygenation (ECMO) is the ultimate treatment option to improve gas exchange and decrease the aggressiveness of mechanical ventilation in septic patients with uncontrolled severe lung failure. However, potential microbiological colonization of the artificial surfaces of membrane oxygenator (MO) remains a critical issue in patients with bacteremia. The current study investigates the risk of MO infection in 10 consecutive septic patients on long‐term treatment with ECMO. The flushing fluids of all investigated MOs were sterile. After incubation with nutrient solution for 14 days in one MO Enterococci spp. were isolated. In the patient concerned, a diffuse, unaccountable bleeding diathesis had developed, which stopped after exchange of the MO. Analysis of clinical parameters showed that D dimers had increased and fibrinogen levels had decreased before exchange of this MO, but standard markers of infection had remained unremarkable. In conclusion, circuit infection may be a potential cause for unexplained clinical deterioration of patients on ECMO, which therefore should be considered as an indication for exchange of the device.
Use of Skin Stretchers to Elongate a Peninsular Thoracodorsal Axial Pattern Flap for Antebrachial Wound Closure in a Dog
Authors: Holt David E. , Runge Jeffrey 
Published: February 2011

Objective: To describe preoperative use of skin stretchers to elongate a peninsular thoracodorsal axial pattern flap to close a large antebrachial wound on a dog.Study Design: Case report.Animals: A 21 kg, 7‐year‐old, male intact mixed breed dog.Methods: Two skin stretchers were applied to the site of the thoracodorsal axial pattern flap 4 days before surgery. The elastic cables connecting the adhesive pads were tightened daily to increase the skin available for a peninsular thoracodorsal axial pattern flap, which was created and rotated 180° to cover an antebrachial defect to a level 2 cm proximal to the carpus.Results: The entire flap survived; there was a small amount of incisional separation at the distal margin of the flap that healed without further treatment.Conclusion: Preoperative skin stretching provided additional skin for the axial pattern flap used.
Symptomatic parvovirus B19 infection caused by blood component transfusion
Authors: Satake Masahiro , Hoshi Yuji , Taira Rikizo , Momose Shun‐ya , Hino Satoru , Tadokoro Kenji 
Published: February 2011

BACKGROUND: Although a risk of transfusion‐transmitted human parvovirus B19V (TT‐B19V) infection has been a concern, there have been very few reports of clinically relevant TT‐B19V caused by the transfusion of a B19V‐containing blood component. It has therefore been a matter of debate whether a universal B19V screening with an appropriate sensitivity is required.STUDY DESIGN AND METHODS: Through the Japanese Red Cross hemovigilance system, clinical reports on possible TT‐B19V were collected from 1999 to 2008, during which B19V donor screening (sensitivity, 1010 IU/mL) was conducted and repository blood samples from donors were available.RESULTS: Eight patients with TT‐B19V caused by component transfusion have been identified. Four patients developed sustained anemia and pure red blood cell (RBC) aplasia and one patient developed pancytopenia. The underlying diseases in these five patients were either hematologic malignancy or hemolytic diseases. The viral loads of the responsible components for these cases ranged from 103 to 108 IU/mL. Two patients who underwent surgical treatment without any hematologic disorder exhibited only moderate symptoms. The B19V DNA sequence identity between a patient and the linked blood donor was confirmed in five of the eight patients. All of the components responsible for the eight cases were positive for anti‐B19V immunoglobulin (Ig)M.CONCLUSION: Vulnerability to serious B19V‐related hematologic disorders depended on the patient's underlying disease state of an enhanced erythropoiesis, not on the viral load of the component transfused. To prevent clinically relevant TT‐B19V, a strategy is suggested in which patients at risk of acquiring RBC aplasia or pancytopenia are targeted.
How do implant surface characteristics influence peri‐implant disease?
Authors: Renvert Stefan , Polyzois Ioannis , Claffey Noel 
Published: February 2011

Renvert S, Polyzois I, Claffey N. How do implant surface characteristics influence peri‐implant disease? J Clin Periodontol 2011; 38 (Suppl. 11): 214–222. doi: 10.1111/j.1600‐051X.2010.01661.x.AbstractObjectives: To review the literature on how implant surface characteristics influence peri‐implant disease.Material and Methods: A search of PubMed and The Cochrane Library of the Cochrane Collaboration (CENTRAL) as well as a hand search of articles were conducted. Publications and articles accepted for publication up to March 2010 were included.Results: Thirteen studies were selected for the review. Human studies: To date, few studies have investigated if such differences occur. Limited data suggest that smooth surfaces may be less affected by peri‐implantitis than rough surface implants. Animal studies: In ligature‐induced peri‐implantitis studies, no difference between surfaces has been reported. In a spontaneous progression model of peri‐implantitis, there was a suggestion that the progression was more pronounced at implants with a porous anodized surface.Conclusion: The current review revealed that only a few studies provided data on how implant surfaces influence peri‐implant disease. Based on the limited data available, there is no evidence that implant surface characteristics can have a significant effect on the initiation of peri‐implantitis.
Antimicrobial peptides and periodontal disease
Authors: Gorr Sven‐Ulrik , Abdolhosseini Mahsa 
Published: February 2011

Gorr S‐U, Abdolhosseini M. Antimicrobial peptides and periodontal disease. J Clin Periodontol 2011; 38 (Suppl. 11): 126–141. doi: 10.1111/j.1600‐051X.2010.01664.x.AbstractAims: The goal of this review is to identify the antimicrobial proteins in the oral fluids, saliva and gingival crevicular fluid and identify functional families and candidates for antibacterial treatment.Results: Periodontal biofilms initiate a cascade of inflammatory and immune processes that lead to the destruction of gingival tissues and ultimately alveolar bone loss and tooth loss. Treatment of periodontal disease with conventional antibiotics does not appear to be effective in the absence of mechanical debridement. An alternative treatment may be found in antimicrobial peptides and proteins, which can be bactericidal and anti‐inflammatory and block the inflammatory effects of bacterial toxins. The peptides have co‐evolved with oral bacteria, which have not developed significant peptide resistance. Over 45 antibacterial proteins are found in human saliva and gingival crevicular fluid. The proteins and peptides belong to several different functional families and offer broad protection from invading microbes. Several antimicrobial peptides and proteins (AMPs) serve as templates for the development of therapeutic peptides and peptide mimetics, although to date none have demonstrated efficacy in human trials.Conclusions: Existing and newly identified AMPs may be developed for therapeutic use in periodontal disease or can serve as templates for peptide and peptide mimetics with improved therapeutic indices.
The characteristics of biofilms in peri‐implant disease
Authors: Mombelli Andrea , Décaillet Fabien 
Published: February 2011

Mombelli A, Décaillet F. The characteristics of biofilms in peri‐implant disease. J Clin Periodontol 2011; 38 (Suppl. 11): 203–213. doi: 10.1111/j.1600‐051X.2010.01666.x.AbstractAim: To describe the microbiota associated with peri‐implant disease, with a specific emphasis on the differential diagnosis of the condition.Material and Methods: The potentially relevant literature was preliminarily assessed via scoping searches to find the most appropriate search terms and the most efficient Boolean search algorithm. We identified 29 reports on subjects with osseointegrated implants, with a pathological condition compatible with the definition of “peri‐implant disease”, and reporting microbiological data from samples taken in affected sites.Results and Conclusions: In most studies bacterial samples were obtained by methods that destroy the three‐dimensional structure of the biofilm. The samples therefore describe mixtures of bacteria from unspecified districts of biofilm associated with peri‐implant diseases. Analyses of such samples with various methods indicate that peri‐implant disease maybe viewed as a mixed anaerobic infection. In most cases the composition of the flora is similar to the subgingival flora of chronic periodontitis that is dominated by Gram‐negative bacteria. Peri‐implant infections may occasionally be linked to a different microbiota, including high numbers of peptostreptococci or staphylococci. Beneficial effects of mechanical and chemical interventions to disrupt the peri‐implant biofilm demonstrate that microorganisms are involved in the disease process, even if they may not always be the origin of the condition.
How has neutrophil research improved our understanding of periodontal pathogenesis?
Authors: Nussbaum Gabriel , Shapira Lior 
Published: February 2011

Nussbaum G, Shapira L: How has neutrophil research improved our understanding of periodontal pathogenesis? J Clin Periodontol 2011; 38 (Suppl. 11): 49–59. doi: 10.1111/j.1600‐051X.2010.01678.x.AbstractBackground: Neutrophils are the predominant cells responsible for host defence against bacterial infection. Loss of neutrophil defence, due either to deficient number or function, strongly predisposes to bacterial infections such as periodontitis. Yet, the neutrophil oxidative and proteolytic arsenal has also been implicated in perpetrating periodontal tissue damage in periodontitis.Aim: In this review, we focus on recent developments that shed light on these two aspects of neutrophil function in periodontitis.Methods: Primary search: using PubMed search for “neutophil”, “periodontal”, and “periodontitis”. Secondary search: using references from the articles found in the first stage.Results: Early histological studies showed that infiltrating neutrophils form a wall of cells abutting the junctional epithelium in periodontal inflammatory lesions. The chronic standoff between these neutrophils and the bacterial community suggests that bacterial evasion of neutrophil clearance is a major characteristic of periodontitis. Indeed, not all functional neutrophil deficiencies increase the risk of periodontitis, an observation that points the way towards identification of particular anti‐bacterial pathways essential for protection against periodontal pathogens. The net result in the majority of periodontitis patients who exhibit normal neutrophil number and function, is that neutrophils accumulate in the periodontal tissue where they are available to participate in tissue destruction. Diminished neutrophil clearance further contributes to the persistence of activated neutrophils in the periodontal tissue.Conclusions: Data on the role of neutrophils in the pathogenesis of periodontitis are mixed. Neutrophils are a critical arm of the defence against periodontitis, but bacterial evasion of the neutrophil microbicidal machinery coupled with delayed neutrophil apoptosis may transform the neutrophil from defender to perpetrator. At this stage of knowledge, attempts to induce host modulation through neutrophil suppression or activation are premature.
Has the use of molecular methods for the characterization of the human oral microbiome changed our understanding of the role of bacteria in the pathogenesis of periodontal disease?
Authors: Wade William Geoffrey 
Published: February 2011

Wade WG. Has the use of molecular methods for the characterization of the human oral microbiome changed our understanding of the role of bacteria in the pathogenesis of periodontal disease?J Clin Periodontol 2011; 38 (Suppl. 11): 7–16. doi: 10.1111/j.1600‐051X.2010.01679.xAbstractBackground: Only around half of oral bacteria can be grown in the laboratory using conventional culture methods. Molecular methods based on 16S rRNA gene sequence are now available and are being used to characterize the periodontal microbiota in its entirety.Aim: This review describes the cultural characterization of the oral and periodontal microbiotas and explores the influence of the additional data now available from culture‐independent molecular analyses on current thinking on the role of bacteria in periodontitis.Results: Culture‐independent molecular analysis of the periodontal microbiota has shown it to be far more diverse than previously thought. A number of species including some that have yet to be cultured are as strongly associated with disease as those organisms traditionally regarded as periodontal pathogens. Sequencing of bacterial genomes has revealed a high degree of intra‐specific genetic diversity.Conclusions: The use of molecular methods for the characterization of the periodontal microbiome has greatly expanded the range of bacterial species known to colonize this habitat. Understanding the interactions between the human host and its commensal bacterial community at the functional level is a priority.
What can we learn about biofilm/host interactions from the study of inflammatory bowel disease
Authors: Indriolo Amedeo , Greco Salvatore , Ravelli Paolo , Fagiuoli Stefano 
Published: February 2011

Indriolo A, Greco S, Ravelli P, Fagiuoli S. What can we learn about biofilm/host interactions from the study of inflammatory bowel disease. J Clin Periodontol 2011; 38 (Suppl. 11): 36–43. doi: 10.1111/j.1600‐051X.2010.01680.x. AbstractObjectives: The aim of this review was to evaluate possible common pathogenic pathways and risk factors in inflammatory bowel disease (IBD) and periodontitis.Materials and Methods: A MEDLINE–PubMed research was conducted.Results: The pathogenesis of both diseases is multi‐factorial leading to a substantial defect of the mucosal barrier, deregulation of the immune response and chronic inflammation of the mucosa. Environmental factors, particularly bacteria, are key factors in the pathogenesis of both diseases. Genetic predisposition is a key factor in the IBD pathogenesis, while a clear role of genetics in the pathogenesis of periodontitis is still unclear. The immune response in IBD is mediated by T lymphocytes as a consequence of a genetic trait associated with T‐cell deregulation. On the other hand, in periodontitis plasma cells and lymphocytes are the predominant cells in the chronic inflammatory lesion, with the presence of B cells being proportionally larger than T cells.Conclusion: IBD and periodontitis share several factors in their aetiology and pathogenesis, although they also have distinct characteristics.
Host‐response: understanding the cellular and molecular mechanisms of host‐microbial interactions – Consensus of the Seventh European Workshop on Periodontology
Authors: Kinane Denis F. , Preshaw Philip M. , Loos Bruno G. ,   on Behalf of Working Group 2 of the Seventh European Workshop on Periodontology (in alphabetical order)
Published: February 2011

AbstractBackground: Major challenges in periodontology include understanding the pathophysiology, the interplay between various components of the host response, parallels with other diseases and identifying biomarkers of the disease.Objectives: Four reviews were compiled with the aim of better understanding: (1) the role of polymorphic nuclear leucocytes (PMNs), i.e. neutrophils; (2) the function of cytokine networks in the host response; (3) whether parallels exist with rheumatoid arthritis (RA); and (4) whether useful biomarkers currently exist to help in the management of periodontal disease.Material and Methods: Based on the focused questions, electronic and manual searches were conducted for human, animal and cellular studies on the above topics.Results: Papers fulfilling the inclusion criteria were selected and reviews were written and reviewed and corrected before the academy meeting to produce consensus statements.Conclusion: The following consensus statements were produced. PMNs are important in the pathophysiology of periodontal disease but there is limited evidence on their much quoted destructive potential. Cytokine networks are enormously complex and we are really at the beginning of understanding their role in the disease process. RA has both similarities and marked differences to periodontal disease although the existing utilization of anti‐cytokine therapies and other molecules in its treatment may have importance in periodontal disease therapy. Biomarkers for periodontal disease have yet to be completely defined but the ratio of receptor activator of NF‐κB ligand to osteoprotegerin appears to be a biomarker test with utility for detecting bone destruction.
Impact of WWOX alterations on p73, ΔNp73, p53, cell proliferation and DNA ploidy in salivary gland neoplasms
Authors: Gomes CC , Diniz MG , Oliveira CS , Tavassoli M , Odell EW , Gomez RS , De Marco L 
Published: February 2011

Oral Diseases
17, 564–571Objective:  WWOX gene is altered in a variety of neoplasms. Wwox is pro‐apoptotic through interaction with p73 and may be involved in chromosomal stability by interaction with p73 and p53. The aims of this study were to characterize WWOX transcription, methylation status and immunoexpression in salivary neoplasms and to determine whether these were associated with p73, p53, cell proliferation and DNA ploidy.Materials and Methods:  Seven malignant and 21 benign fresh salivary neoplasms were included. WWOX expression was determined by RT‐PCR and sequencing of transcripts, quantitative PCR and immunohistochemistry. Methylation‐specific PCR was used to assess the methylation of its first exon. For p73, ΔNp73, p53 and ki67 immunohistochemistry and ploidy analysis, 29 malignant samples from archives were included.Results:  No consistent pattern of WWOX exon 1 methylation was found, but aberrant and novel transcripts were observed in 17/28 neoplasms; 55% of tumours showed reduced WWOX RNA. WWOX RNA levels were associated with p53 immunopositivity. Immunohistochemical Wwox expression did not correlate with methylation status, p53 or p73 expression or proliferation. p73, proliferation and DNA ploidy were associated with malignant phenotype.Conclusion:  Aberrant WWOX transcription and decreased expression are frequent in salivary neoplasms and WWOX transcription is associated with p53 staining.
Sexual Functioning in Male Survivors of Lymphoma: A Systematic Review (CME)
Authors: Arden-Close Emily , Eiser Christine , Pacey Allan 
Published: February 2011

Abstract

Introduction
The lymphomas (Hodgkin's lymphoma [HL] and non-Hodgkin's lymphoma [NHL]) are among the most common cancers affecting men under 45 years. Survival rates are now excellent, but treatment is associated with a number of side effects including sexual dysfunction with potential implications for compromised quality of life (QoL).

Aims
To address the (i) prevalence of sexual dysfunction among lymphoma survivors relative to the general population, survivors of other cancers, and in survivors of HL and NHL; and (ii) relationships between sexual functioning and disease and treatment, demographic, and psychological variables.

Methods
Inclusion criteria were quantitative studies that focused on adult male survivors of lymphoma and included a comparison group and presented results separately for HL and NHL. Standardized systematic searches were used. Information about design, sample size, age, time since diagnosis, type of treatment, comparison group, measures, and findings were extracted from eligible studies.

Results
Ten articles met the inclusion criteria, of which, nine included patients with HL only, and one included patients with HL or NHL. Sexual function was compromised relative to the general population, better than testicular cancer survivors, and worse than leukemia survivors. Depression was consistently associated with sexual dysfunction. There was evidence that chemotherapy, relapse, reduced testosterone levels, older age at survey, and worse physical QoL were associated with worse sexual function.

Conclusions
Conclusions are limited by methodological issues including lack of utilization of standardized measures of sexual function and longitudinal research. Even so, there is evidence of sexual dysfunction among lymphoma survivors. Clinicians need to be sensitive to these issues. Future longitudinal work is necessary to determine the likelihood of recovery.
Idiosyncratic Heart Rate Response in Men During Sexual Arousal
Authors: Rowland David L. , Crawford Sara B. 
Published: February 2011

ABSTRACT

Introduction
Heart rate, sensitive to sympathetic activation, is known to change during sexual arousal and therefore may be a useful tool for investigating psychosomatic differences between sexually functional and dysfunctional men. However, heart rate during arousal also tends to be highly variable across individual men, making its predictability based on group patterns relatively poor.

Aim
We wanted to determine whether individual men show idiosyncratic heart rate patterns during sexual arousal, that is, whether they exhibit consistent patterns across similar (though not identical) stimulus situations.

Main Outcome Measure
Agreement between heart rates under the two conditions, visual sexual stimulation (VSS) and VSS+vibrotactile (VIB), was assessed using the concordance correlation coefficient (CCC).

Methods
Thirty-eight men, 25 of whom were diagnosed with premature ejaculation (PE), were monitored for penile response and heart rate under two similar (though not identical) conditions: a 9-minute erotic video (VSS), then a 9-minute erotic video combined with vibrotactile penile stimulation (VSS+VIB).

Results
CCC for men with PE was 0.65; for the sexually functional comparison group, CCC was 0.82. For both groups combined, CCC was 0.71. For all groupings, the CCC was relatively high, indicating agreement in heart rate from one session to the next within individual men.

Conclusions
Despite high intersubject variation in heart rate patterns, individual men show signature heart rates across similar sexual stimulus sessions. Such stereotypy helps explain previous inconsistent findings and may also serve as a marker for the effectiveness of treatments designed to improve ejaculatory control in men with PE.