bluuebunny/crossref_metadata_2025_split huggingface dataset:
Chromosomal aberrations +1q21 and del(17p13) predict survival in patients with recurrent multiple myeloma treated with lenalidomide and dexamethasone
Authors: Klein Ulrike , Jauch Anna , Hielscher Thomas , Hillengass Jens , Raab Marc S. , Seckinger Anja , Hose Dirk , Ho Anthony D. , Goldschmidt Hartmut , Neben Kai 
Published: December 2010

AbstractBACKGROUND:In the era of novel agents such as lenalidomide and bortezomib, risk stratification by chromosomal abnormalities may enable a more rational selection of therapeutic approaches in patients with multiple myeloma (MM).METHODS:The authors analyzed the prognostic value of deletion del(13q14), del(17p13), +1q21, translocation t(4;14), t(11;14), and t(14;16) by fluorescence in situ hybridization (FISH) in a series of 92 patients with recurrent MM who were treated with lenalidomide and dexamethasone (len/dex) at the study center.RESULTS:Patients carrying del(13q14) or t(14;16) were found to have a shorter median time to disease progression (TTP) of 5.1 months (vs 14.4 months; P = .009) and 2.0 months (vs 10.5 months; P <.001), respectively. However, no effect on TTP was observed in patients harboring del(13q14) as an exclusive chromosomal aberration without the concomitant presence of t(4;14) or del(17p13). The median overall survival (OS) for patients with del(17p13) or +1q21 was 6.7 months (P = .002) and 8.3 months (P < .001), respectively, whereas the median OS for patients carrying none of these abnormalities was not reached. Multivariate analysis revealed that the effects of del(17p13) and +1q21 on OS were independent of patient age as well as the type and number of regimens administered before len/dex.CONCLUSIONS:The results of the current study suggest that the prognostic significance of t(4;14) may be ameliorated or eliminated in patients treated with len/dex, whereas the presence of del(17p13) or +1q21 is still associated with a dismal OS. The presence of t(11;14) and del(13q14) as exclusive chromosomal aberrations indicates no impact on outcome. Because of its rarity in MM, a confirmation of the prognostic role of the t(14;16) aberration is still pending. Cancer 2011. © 2010 American Cancer Society.
The interleukin‐7 receptor α chain contributes to altered homeostasis of regulatory T cells in multiple sclerosis
Authors: Haas Jürgen , Korporal Mirjam , Schwarz Alexander , Balint Bettina , Wildemann Brigitte 
Published: December 2010

AbstractTreg homeostasis is disturbed in multiple sclerosis (MS). Frequencies of recent thymic emigrant (RTE)‐Treg are reduced and the disparity between RTE‐Treg and long‐lived memory Treg coincides with the MS‐associated Treg defect, as shown previously. Recent studies demonstrate that IL‐7 and thymic stromal lymphopoietin (TSLP) are critical for Treg maturation. Therefore, altered signaling through their receptors (IL‐7R, TSLP receptor (TSLPR)), sharing the IL‐7Rα‐chain (IL‐7Rα), might contribute to impaired Treg development. Using blood samples from 56 patients with MS and 33 healthy controls, we assessed IL‐7Rα‐expression on conventional T cells; frequencies, phenotypes and suppressive activities of Treg, plasma levels of IL‐7 and soluble IL‐7Rα; and screened for MS‐associated IL‐7RA gene polymorphism rs6897932. Moreover, we determined Treg expressing two different TCR Vα‐chains designating thymus‐originated cells. As TSLP/TSLPR signaling in thymic myeloid dendritic cells (MDCs) promotes Treg differentiation, we measured TSLPR expression on peripheral MDCs to indirectly test whether altered TSLPR expression might add to compromised Treg neogenesis. We found reduced IL‐7Rα expression on conventional T cells and upregulated IL‐7 plasma levels together with reduction of RTE‐Treg frequencies and Treg function in MS, without clear genetic influence. Decreased IL‐7Rα expression in MS correlated with declined dual‐receptor‐Treg and reduced MDC TSLPR expression, indicating contracted thymic Treg output. We suggest that altered IL‐7R/TSLPR signaling contributes to impaired Treg neogenesis in MS, which is compensated by expanded memory‐Treg and finally results in dysfunctional Treg.
Reactions of Selected Aromatic Thioketones with Dodecarbonyltriiron
Authors: Daraosheh Ahmad Q. , Görls Helmar , El‐khateeb Mohammad , Mloston Grzegorz , Weigand Wolfgang 
Published: December 2010

AbstractDodecacarbonyltriiron reacts with 3,3,5,5‐tetraphenyl‐1,2,4‐trithiolanes (1e) to give the ortho‐metalated complex Fe2(CO)6[κ,μ‐S,η2‐(C13H10S)] (9a), complexes of the type (Ph2C)S2Fe2(CO)6 and the well known trinuclear complex Fe3S2 (CO)9 as by‐products. Complex 9a can also be obtained from the reaction of Fe3(CO)12 with thiobenzophenone (2a). In a similar way, 4,4′‐bis(dimethylamino)thiobenzophenone (2b) reacts with Fe3(CO)12 to give Fe2(CO)6[κ,μ‐S,η2‐(C17H20N2S)] (9b). The cyclic aromatic thioketones such as dibenzosuberenethione (2c) and xanthione (2d) react with Fe3(CO)12 to give the cyclometalated products Fe2(CO)6[κ,μ‐S,η2‐(C15H12S)] (9c) and Fe2(CO)6[κ,μ‐S,η2‐(C13H8OS)] (9d), respectively, and a small amount of Fe3S2(CO)9. Complexes 9a–d have been characterized by IR and NMR spectroscopies, elemental analyses, and X‐ray single crystal structure analyses.
Water‐Soluble and Biocompatible Cyclometalated Iridium(III) Complexes: Synthesis, Luminescence and Sensing Application
Authors: Li Mei‐Jin , Jiao Pengchong , He Weiwen , Yi Changqing , Li Cheuk‐Wing , Chen Xi , Chen Guo‐Nan , Yang Mengsu 
Published: December 2010

AbstractTwo new iridium(III) complexes with good water‐solubility and biocompatibility have been synthesized and characterized. These two iridium(III) complexes showed strong luminescence with high quantum efficiency. Preliminary experiments demonstrated the feasibility of sensing lectin by formation of iridium(III) complexes. These new iridium(III) complexes might open up new applications in biosensor and chemosensor.
Using NMR and ESI‐MS to Probe the Mechanism of Silane Dehydrocoupling Catalyzed by Wilkinson's Catalyst
Authors: Jackson Sarah M. , Chisholm Danielle M. , McIndoe J. Scott , Rosenberg Lisa 
Published: December 2010

AbstractThe reaction of Wilkinson's catalyst Rh(PPh3)3Cl (1) with 1–2 equiv. of di‐n‐hexylsilane gives rise to a complex mixture of products, which has been analyzed by 31P{1H} NMR and shown to include the hydrido complex Rh(PPh3)3H (3). Continuous sampling of the 1:1 reaction mixture by ESI‐MS provided time‐dependent speciation that tracks the formation of 3 at the expense of the initial silane oxidative addition product [Rh(PPh3)2(Cl)(H){Si(nHex)2H}] (2), the subsequent 1st order disappearance of 3, and the formation of other, minor side‐products. Our results provide insight into established activity of 1 for catalytic dehydrocoupling of di‐n‐hexylsilane, and implicate complex 3 as the active species in this catalysis.
Racemic and Optically Pure Heptahelicene‐2‐carboxylic Acid: Its Synthesis and Self‐Assembly into Nanowire‐Like Aggregates
Authors: Rybáček Jiří , Huerta‐Angeles Gloria , Kollárovič Adrian , Stará Irena G. , Starý Ivo , Rahe Philipp , Nimmrich Markus , Kühnle Angelika 
Published: December 2010

AbstractHeptahelicene‐2‐carboxylic acid was effectively synthesised from suitably functionalised naphthalene building blocks. Methoxy‐substituted 1,1′‐ethyne‐1,2‐diylbis(2‐but‐3‐yn‐1‐ylnaphthalene) was cyclised in the presence of CpCo(CO)2/PPh3 to 2‐methoxy‐7,8,11,12‐tetrahydroheptahelicene, which was converted into heptahelicen‐2‐yl trifluoromethanesulfonate. This reactive intermediate underwent Pd(OAc)2/dppp‐catalysed methoxycarbonylation reaction to provide, after hydrolysis, heptahelicene‐2‐carboxylic acid. The racemate was resolved into enantiomers by semipreparative HPLC on a chiral column. The helicity of (+)‐(P)‐heptahelicene‐2‐carboxylic acid was assigned by correlating its CD spectrum to that of the known (+)‐(P)‐heptahelicene. Racemic heptahelicene‐2‐carboxylic acid was deposited on calcite (10‐14) to undergo self‐assembly into nanowire‐like aggregates as demonstrated by noncontact atomic force microscopy (NC‐AFM).
Synthesis and Application of Diphenyl Sulfide Linked Bis(imidazoline) Ligands: Dramatic Electronic Effect of Ligands on Catalytic Behavior
Authors: Du Xian , Liu Han , Du Da‐Ming 
Published: December 2010

AbstractDiphenyl sulfide linked bis(imidazoline) ligands with electron‐withdrawing N‐Ts substitution and electron‐donating N‐alkyl or N‐H substitutions were synthesized through different routes. The electronic effects of the ligands were tuned rationally, and dramatic variation in their catalytic behavior was observed. N‐Alkyl and N‐H ligands demonstrated much higher catalytic activity and improved enantioselectivity than N‐Ts ligands in Pd‐catalyzed asymmetric allylic alkylation reactions.
New challenges for tafoni research. A new approach to understand processes and weathering rates
Authors: Brandmeier M. , Kuhlemann J. , Krumrei I. , Kappler A. , Kubik P.W. 
Published: December 2010

AbstractCavernous tafoni‐type weathering is a common and conspicuous global feature, creating artistic sculptures, which may be relevant for geochemical budgets. Weathering processes and rates are still a matter of discussion. Field evidence in the type locality Corsica revealed no trend of size variability from the coast to subalpine elevations and the aspect of tafoni seems to be governed primarily by the directions of local fault systems and cleavage, and only subordinately by wind directions or the aspect of insulation. REM analysis of fresh tafone chips confirmed mechanical weathering by the crystallization of salts, as conchoidal fracturing of quartz is observed. The salts are only subordinately provided by sea spray, as calcium and sodium sulfates rather than halite dominate even close to the coast. Characteristic element ratios compare well with aerosols from mixed African and European air masses. Sulfates are largely derived from Sahara dust, indicated by their sulfur isotopic composition. Salt crystals form by capillary rise within the rock and subsequent crystallization in micro‐cracks and at grain boundaries inside rain‐protected overhangs. Siderophile bacteria identified by raster electron microscopy (REM) analysis of tafone debris contribute to accelerated weathering of biotite and tiny sulfide ore minerals. By applying 10Be‐exposure dating, weathering rates of large mature tafone structures were found to be about an order of magnitude higher than those on the exposed top of the affected granite blocks. Copyright © 2010 John Wiley & Sons, Ltd.
STATCOM modeling impacts on performance evaluation of distance protection of transmission lines
Authors: Khederzadeh Mojtaba , Ghorbani Amir 
Published: December 2010

AbstractIn this paper, the impact of STATCOM on the apparent impedance seen by conventional distance relay protecting a transmission line is investigated. Analytical results are presented, and verified by detailed simulations. It is shown that the implications of applying STATCOM on distance relay are highly dependent on the sophisticated modeling of STATCOM especially its control system considering practical constraints. Accurate modeling of the distance relay, particularly the analog input signals are also important in extracting reliable results. Practical constraints of the STATCOM are modeled in full details. It is demonstrated that when the STATCOM's limits are modeled in detail, i.e., the STATCOM is not considered an ideal reactive‐power source the STATCOM's impact on the performance of distance protection is less severe than in the case where limits are ignored and thus ideal controllers are applied. This is a remarkable point for the utilities as not to overestimate the severity of the impact of STATCOM on conventional distance protection of transmission lines. Six different phase‐to‐phase and phase‐to‐ground measuring units of the distance relay are simulated to resemble the behavior of the relay. Different power system operating conditions, STATCOM control system settings and fault scenarios are investigated. The STATCOM effects on distance relay tripping characteristics are also analyzed. Copyright © 2010 John Wiley & Sons, Ltd.
Intensity‐dependent constitutional MLH1 promoter methylation leads to early onset of colorectal cancer by affecting both alleles
Authors: Auclair Jessie , Vaissière Thomas , Desseigne Françoise , Lasset Christine , Bonadona Valérie , Giraud Sophie , Saurin Jean‐Christophe , Joly Marie‐Odile , Leroux Dominique , Faivre Laurence , Audoynaud Carole , Montmain Gilles , Ruano Eric , Herceg Zdenko , Puisieux Alain , Wang Qing 
Published: December 2010

AbstractConstitutional epimutation is one of the causes for MLH1 gene inactivation associated with hereditary non‐polyposis colon cancer (HNPCC) syndrome. Here we investigate MLH1 promoter hypermethylation in 110 sporadic early‐onset colorectal cancer patients. Variable levels of hypermethylation were detected in 55 patients (50%). Importantly a reduced MLH1 gene expression was found in patients with high‐level methylation, with the association of microsatellite instability (MSI) in their tumor cells. Such high‐level methylation accounts for 7.4% of all patients included in this study. Furthermore, we found that in one case constitutional methylation affected both alleles, indicating a post‐zygotic methylation dysregulation. Our findings suggest that constitutional epimutation is a mechanism underlying early‐onset colorectal cancer, although it is involved in only a small proportion of patients, who require appropriate surveillance. Our findings provide further insight into the role of aberrant constitutional methylation in colon carcinogenesis and raise the question of whether prevalent low‐level methylation constitutes a potential risk factor for cancer development. © 2010 Wiley‐Liss, Inc.
Synergistic action of hypoosmolarity and glutamine in inducing acute swelling of retinal glial (Müller) cells
Authors: Karl Anett , Wurm Antje , Pannicke Thomas , Krügel Katja , Obara‐Michlewska Marta , Wiedemann Peter , Reichenbach Andreas , Albrecht Jan , Bringmann Andreas 
Published: December 2010

AbstractHigh blood ammonia, elevated glutamine, and hyponatremia are pathogenic factors contributing to astrocytic swelling and brain edema in liver failure. We investigated the effects of hypoosmolarity, ammonia, and glutamine on the induction of glial cell swelling in freshly isolated slices of the rat retina. Glutamine, but not ammonia or hypoosmolarity per se, evoked a rapid (within one minute) swelling of retinal glial (Müller) cell bodies under hypoosmotic conditions. Under isoosmotic conditions, glutamine evoked a delayed swelling after 10 min of exposure. The effect of glutamine was concentration‐dependent, with half‐maximal and maximal effects at ∼ 0.1 and 0.5 mM. Glutamine in hypoosmotic solution induced a dissipation of the mitochondrial membrane potential. The effects on the mitochondrial membrane potential and the glial soma size were reduced by (i) agents which inhibit the transfer of glutamine into mitochondria and its hydrolysis there, (ii) inhibition of the mitochondrial permeability transition, (iii) inhibitors of oxidative‐nitrosative stress, and (iv) inhibitors of phospholipase A2 and cyclooxygenase. Glutamine‐induced glial swelling was also prevented by ATP and adenosine, acting at adenosine A1 receptors. The data suggest that hypoosmolarity accelerates the swelling‐inducing effect of glutamine on retinal glial cells, and that swelling induction by glutamine is mediated by inducing oxidative‐nitrosative stress, inflammatory lipid mediators, and mitochondrial dysfunction. © 2010 Wiley‐Liss, Inc.
Public and private health‐care financing with alternate public rationing rules
Authors: Cuff Katherine , Hurley Jeremiah , Mestelman Stuart , Muller Andrew , Nuscheler Robert 
Published: December 2010

SUMMARYWe develop a model to analyze parallel public and private health‐care financing under two alternative public sector rationing rules: needs‐based rationing and random rationing. Individuals vary in income and severity of illness. There is a limited supply of health‐care resources used to treat individuals, causing some individuals to go untreated. Insurers (both public and private) must bid to obtain the necessary health‐care resources to treat their beneficiaries. Given individuals' willingnesses‐to‐pay for private insurance are increasing in income, the introduction of private insurance diverts treatment from relatively poor to relatively rich individuals. Further, the impact of introducing parallel private insurance depends on the rationing mechanism in the public sector. We show that the private health insurance market is smaller when the public sector rations according to need than when allocation is random. Copyright © 2010 John Wiley & Sons, Ltd.
Oncogenic osteomalacia from nasal cavity giant cell tumor
Authors: Battoo Azhar Jan , Salih Surij , Unnikrishnan Ambika Gopalakrishnan , Jojo Annie , Bahadur Sudhir , Iyer Subramania , Kuriakose Moni Abraham 
Published: December 2010

AbstractBackgroundOncogenic osteomalacia is a rare paraneoplastic syndrome characterized by osteomalacia, which occurs as a result of excess renal phosphate excretion caused by fibroblast growth factor–23 secreted by mesenchymal tumors. This entity is rare in head and neck cancers. We report a rare case of oncogenic osteomalacia in a patient with an anterior skull base giant cell tumor.Methods and ResultsA 34‐year‐old woman presented with a 5‐year history of progressive weakness in both lower limbs and the trunk. Hypophosphatemia and hypocalcemia had been noted by a local physician, but her symptoms persisted despite receiving calcium and vitamin D supplements. A recent onset of epistaxis and nasal blockage led to referral to the head and neck services. Nasal endoscopy revealed a left nasal cavity mass. Further evaluation with imaging studies revealed a mass in the nasal cavity with intracranial extension. Biopsy of the lesion suggested a neurogenic tumor. A putative diagnosis of anterior skull base neurogenic tumor with paraneoplastic hypophosphatemia was made. After the biochemical parameters were corrected, the patient underwent craniofacial resection. The final histopathologic study suggested the lesion as a “giant cell tumor.” During the postoperative period the patient's biochemical and clinical symptoms improved dramatically, allowing her to regain normal mobility.ConclusionsClinicians and pathologists must be aware of the clinical symptoms, laboratory abnormalities, and pathologic features of oncogenic osteomalacia, which may be caused by tumors in the head and neck and thus make an exhaustive effort to diagnose the same. © 2010 Wiley Periodicals, Inc. Head Neck, 2012
In vivo performance of a phospholipid‐coated bioerodable elastomeric graft for small‐diameter vascular applications
Authors: Soletti Lorenzo , Nieponice Alejandro , Hong Yi , Ye Sang‐Ho , Stankus John J. , Wagner William R. , Vorp David A. 
Published: December 2010

AbstractThere remains a great need for vascular substitutes for small‐diameter applications. The use of an elastomeric biodegradable material, enabling acute antithrombogenicity and long‐term in vivo remodeling, could be beneficial for this purpose. Conduits (1.3 mm internal diameter) were obtained by electrospinning biodegradable poly(ester urethane)urea (PEUU), and by luminally immobilizing a non‐thrombogenic, 2‐methacryloyloxyethyl phosphorylcholine (MPC) copolymer. Platelet adhesion was characterized in vitro after contact with ovine blood. The conduits were implanted as aortic interposition grafts in the rat for 4, 8, 12, and 24 weeks. Surface treatment resulted in a 10‐fold decrease in platelet adhesion compared to untreated material. Patency at 8 weeks was 92% for the coated grafts compared to 40% for the non‐coated grafts. Histology at 8 and 12 weeks demonstrated formation of cellularized neotissue consisting of aligned collagen and elastin. The lumen of the grafts was confluent with cells qualitatively aligned in the direction of blood flow. Immunohistochemistry suggested the presence of smooth muscle cells in the medial layer of the neotissue and endothelial cells lining the lumen. Mechanically, the grafts were less compliant than rat aortas prior to implantation (4.5 ± 2.0 × 10−4 mmHg−1 vs. 14.2 ± 1.1 × 10−4 mmHg−1, respectively), then after 4 weeks in vivo they approximated native values, but subsequently became stiffer again at later time points. The novel coated grafts exhibited promising antithrombogenic and mechanical properties for small‐diameter arterial revascularization. Further evaluation in vivo will be required to demonstrate complete remodeling of the graft into a native‐like artery. © 2010 Wiley Periodicals, Inc. J Biomed Mater Res Part A:, 2011.
Honokiol inhibits LPS‐induced maturation and inflammatory response of human monocyte‐derived dendritic cells
Authors: Li Chia‐Yang , Chao Louis Kuoping , Wang Shu‐Chi , Chang Hon‐Zu , Tsai Min‐Lung , Fang Shih‐Hua , Liao Pei‐Chun , Ho Chen‐Lung , Chen Shui‐Tein , Cheng Wei‐Chung , Chiang Chi‐Shiun , Kuo Yueh‐Hsiung , Hua Kuo‐Feng , Hsu Ian C. 
Published: December 2010

AbstractHonokiol (HNK) is a phenolic compound isolated from the bark of houpu (Magnolia officinalis), a plant widely used in traditional Chinese and Japanese medicine. While substantial evidence indicates that HNK possesses anti‐inflammatory activity, its effect on dendritic cells (DCs) during the inflammatory reaction remains unclear. The present study investigates how HNK affects lipopolysaccharide (LPS)‐stimulated human monocyte‐derived DCs. Our experimental results show that HNK inhibits the inflammatory response of LPS‐induced DCs by (1) suppressing the expression of CD11c, CD40, CD80, CD83, CD86, and MHC‐II on LPS‐activated DCs, (2) reducing the production of TNF‐α, IL‐1β, IL‐6, and IL‐12p70 but increasing the production of IL‐10 and TGF‐β1 by LPS‐activated DCs, (3) inhibiting the LPS‐induced DC‐elicited allogeneic T‐cell proliferation, and (4) shifting the LPS‐induced DC‐driven Th1 response toward a Th2 response. Further, our results show that HNK inhibits the phosphorylation levels of ERK1/2, p38, JNK1/2, IKKα, and IκBα in LPS‐activated DCs. Collectively, the findings show that the anti‐inflammatory actions of HNK on LPS‐induced DCs are associated with the NF‐κB and mitogen‐activated protein kinase (MAPK) signaling pathways. J. Cell. Physiol. 226: 2338–2349, 2011. © 2010 Wiley‐Liss, Inc.