bluuebunny/crossref_metadata_2025_split huggingface dataset:
ChemInform Abstract: Synthesis of Chiral Fluorinated Materials via Biotransformation
Authors: Kitazume Tomoya , Matsuda Tomoko , Nakamura Kaoru 
Published: April 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthetic Approaches to gem‐Difluoromethylene Compounds
Authors: Reddy V. Prakash , Perambuduru Meher , Alleti Ramesh 
Published: April 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: The Chemistry of Interhalogen Monofluorides
Authors: Shellhamer Dale F. , Heasley Victor L. 
Published: April 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Low‐Molecular‐Weight Inhibitors of NF‐ϰB Signalling Pathways
Authors: Dolinnaya N. G. , Kubareva E. A. , Kazanova E. V. , Zigangirova N. A. , Naroditsky B. S. , Gintsburg A. L. , Oretskaya T. S. 
Published: April 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Pharmacological and Therapeutic Secrets of Plant and Brain (Endo)Cannabinoids
Authors: Hanus Lumir Ondrej 
Published: April 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Chemical Synthesis Within Continuous Flow Microreactors
Authors: Watts Paul 
Published: April 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Ex Uno Plures (“Out of One, Many”): New Paradigms for Expanding the Range of Polyolefins Through Reversible Group Transfers.
Authors: Sita Lawrence R. 
Published: April 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Nuclear Magnetic Resonance Spectroscopy in Ionic Liquids
Authors: Giernoth Ralf 
Published: April 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
The geometry and motion of nematode sperm cells
Authors: Demekhin Evgeny , Haugen Nicole , Ibanez Brian , Lederman Jerome , Murphy Kaitlyn , Verzi Diana , Witczak Debra 
Published: April 2009

AbstractThe nematode sperm cell crawls by recycling major sperm protein (MSP) from dimers into subfilaments, filaments, and filament complexes, as a result of thermal writhing in the presence of hydrophobic patches. Polymerization near leading edges of the cell intercolates MSP dimers onto the tips of growing filament complexes, forcing them against the cell boundary, and extending the cytoskeleton in the direction of motion. Strong adhesive forces attach the cell to the substrate in the forward part of the lamellipod, while depolymerization in the rearward part of the cell breaks down the cytoskeleton, contracting the lamellipod and pulling the cell body forward. The movement of these cells, then, is caused by coordinated protrusive, adhesive and contractile forces, spatially separated across the lamellipod. This paper considers a phenomenological model that tracks discrete elements of the cytoskeleton in curvilinear coordinates. The pseudo‐two dimensional model primarily considers protrusion and rotation of the cell, along with the evolution of the cell boundary. General assumptions are that pH levels within the lamellipod regulate protrusion, contraction and adhesion, and that growth of the cytoskeleton, over time, is perpendicular to the evolving cell boundary. The model follows the growth and contraction of a discrete number of MSP fiber complexes, since they appear to be the principle contributors for force generation in cell boundary protrusion and contraction, and the backbone for the dynamic geometry and motion. Cell Motil. Cytoskeleton 2009. © 2009 Wiley‐Liss, Inc.
Searching for Disease Modifiers—PKC Activation and HDAC Inhibition—A Dual Drug Approach to Alzheimer's Disease that Decreases Aβ Production while Blocking Oxidative Stress
Authors: Kozikowski Alan P. , Chen Yihua , Subhasish Tapadar , Lewin Nancy E. , Blumberg Peter M. , Zhong Zhenyu , D'Annibale Melissa A. , Wang Weng‐Long , Shen Yong , Langley Brett 
Published: April 2009

AbstractA series of benzolactam compounds were synthesized, some of which caused a concentration‐dependent increase in sAPPα and decrease in Aβ production in the concentration range of 0.1–10 μM. Moreover, some compounds showed neuroprotective effects in the 10–20 μM range in the HCA cortical neuron model of oxidative stress and no toxicity in measurements of neuron viability by MTT assay, even at the highest concentrations tested (20 μM).magnified imageAlzheimer's disease (AD) is a well‐studied neurodegenerative process characterized by the presence of amyloid plaques and neurofibrillary tangles. In this study, a series of protein kinase C (PKC) activators were investigated, some of which also exhibit histone deacetylase (HDAC) inhibitory activity, under the hypothesis that such compounds might provide a new path forward in the discovery of drugs for the treatment of AD. The PKC‐activating properties of these drugs were expected to enhance the α‐secretase pathway in the processing of amyloid precursor protein (APP), while their HDAC inhibition was anticipated to confer neuroprotective activity. We found that benzolactams 9 and 11–14 caused a concentration‐dependent increase in sAPPα and decrease in β‐amyloid (Aβ) production in the concentration range of 0.1–10 μM, consistent with a shift of APP metabolism toward the α‐secretase‐processing pathway. Moreover, compounds 9–14 showed neuroprotective effects in the 10–20 μM range in the homocysteate (HCA) cortical neuron model of oxidative stress. In parallel, we found that the most neuroprotective compounds caused increased levels of histone acetylation (H4), thus indicating their likely ability to inhibit HDAC activity. As the majority of the compounds studied also show nanomolar binding affinities for PKC, we conclude that it is possible to design, de novo, agents that combine both PKC‐activating properties along with HDAC inhibitory properties. Such agents would be capable of modulating amyloid processing while showing neuroprotection. These findings may offer a new approach to therapies that exhibit disease‐modifying effects, as opposed to symptomatic relief, in the treatment of AD.
EphA2 overexpression is associated with lack of hormone receptor expression and poor outcome in endometrial cancer
Authors: Kamat Aparna A. , Coffey Donna , Merritt William M. , Nugent Elizabeth , Urbauer Diana , Lin Yvonne G. , Edwards Creighton , Broaddus Russell , Coleman Robert L. , Sood Anil K. 
Published: April 2009

AbstractBACKGROUND:EphA2 is a tyrosine kinase receptor in the ephrin family that is implicated in oncogenesis and angiogenesis. The objective of the current investigation was to study the role of EphA2 in endometrial cancer and its relation to steroid hormone receptor expression.METHODS:EphA2, estrogen receptor (ER), progesterone receptor (PR), and Ki‐67 expression levels were evaluated using immunohistochemistry in 139 endometrioid endometrial carcinoma (EEC) samples and in 10 benign endometrial samples. Samples were scored by 2 investigators who were blinded to clinical outcome. The results were correlated with clinicopathologic characteristics using univariate and multivariate analysis. A P value <.05 was considered statistically significant.RESULTS:High expression of EphA2 was detected in 48% of EEC samples versus 10% of benign samples. EphA2 overexpression was associated significantly with high disease stage (P = .04), high tumor grade (P = .003), increased depth of myometrial invasion (P = .05), low ER expression (P = .01), low PR expression (P = .006), and high Ki‐67 expression (P = .04). Low ER and PR expression levels were associated with high tumor grade, positive lymph nodes, high Ki‐67 expression, and high EphA2 expression. On univariate analysis of all patients, high EphA2 expression was associated significantly with shorter disease‐specific survival (DSS) (P < .001). On multivariate analysis, age (P < .001), high disease stage (P = .002), and high EphA2 expression (P = .04) were independent predictors of poor DSS.CONCLUSIONS:EphA2 overexpression was associated with aggressive phenotypic features in EEC and was associated inversely with ER and PR expression. Thus, EphA2 may be an important therapeutic target, especially in patients with hormone receptor‐negative endometrial carcinoma. Cancer 2009. © 2009 American Cancer Society.
Selectively Deposited Silver Coatings on Gold‐Capped Silicon Nanowires for Surface‐Enhanced Raman Spectroscopy
Authors: Becker M. , Stelzner Th. , Steinbrück A. , Berger A. , Liu J. , Lerose D. , Gösele U. , Christiansen S. 
Published: April 2009

AbstractGold caps on silicon nanowires are selectively coated with silver by autometallography (electroless deposition). Changing the conditions of silver deposition, a variety of different coating morphologies can be produced (see figure). The different silver coating morphologies are investigated in terms of their capabilities for surface enhanced Raman scattering (SERS) experiments.magnified imageGold caps on silicon nanowires are hemispherical and only a few tens of nanometers in diameter when grown from metal catalysts by the vapor‐liquid‐solid growth mechanism using chemical vapor deposition. These gold caps are capable of enhancing Raman signals based on the surface‐enhanced Raman scattering effect. The Raman signal can be enhanced even further (by at least one order of magnitude) when silver is selectively deposited onto these gold caps by autometallography (electroless deposition). By changing the silver deposition conditions, different coating morphologies can be realized on the gold caps that range from very thin, smooth layers to uneven and extremely rough coatings. The SERS signal enhancement and the spatial homogeneity of the achievable enhancement are compared for the different silver coatings using a model dye molecule.
Reversible Structural Modulation of Fe–Pt Bimetallic Surfaces and Its Effect on Reactivity
Authors: Ma Teng , Fu Qiang , Su Hai‐Yan , Liu Hong‐Yang , Cui Yi , Wang Zhen , Mu Ren‐Tao , Li Wei‐Xue , Bao Xin‐He 
Published: April 2009

AbstractTunable surface: The surface structure of the Fe–Pt bimetallic catalyst can be reversibly modulated between the iron‐oxide‐rich Pt surface and the Pt‐skin structure with subsurface Fe via alternating reduction and oxidation treatments (see figure). The regenerated active Pt‐skin structure is active in reactions involving CO and/or O.magnified image
DFT/CCSD(T) Investigation of the Interaction of Molecular Hydrogen with Carbon Nanostructures
Authors: Rubeš Miroslav , Bludský Ota 
Published: April 2009

AbstractThe interaction of molecular hydrogen with carbon nanostructures is investigated within the DFT/CC correction scheme. The DFT/CC results are compared with the benchmark calculations at the CCSD(T) level of theory for benzene and naphthalene, and at the MP2 level for the more extended systems. The DFT/CC method offers a reliable alternative to the highly correlated ab initio calculations at a cost comparable to the standard DFT method. The results for H2 adsorbed on graphene as well as single‐wall carbon nanotubes (SWCNT) are presented. The DFT/CC binding energy on graphene of 5.4 kJ mol−1 is in good agreement with experiment (5.00±0.05 kJ mol−1). For (10,10)‐SWCNT, the H2 molecule is mostly stabilized inside the tube with an estimated binding energy of 7.2 kJ mol−1.
Ruthenium‐catalyzed Selective Monoamination of Vicinal Diols
Authors: Bähn Sebastian , Tillack Annegret , Imm Sebastian , Mevius Kathleen , Michalik Dirk , Hollmann Dirk , Neubert Lorenz , Beller Matthias 
Published: April 2009

AbstractHighly selective monoamination of vicinal diols: The reaction of vicinal diols with primary and secondary amines is catalyzed by [Ru3(CO)12] and N‐phenyl‐2‐(dicyclohexyl‐phosphanyl)pyrrole to generate the corresponding amino alcohols with high selectivity and good yields.magnified imageThe monoamination of vicinal diols in the presence of in situ generated ruthenium catalysts has been investigated. Among the various phosphines tested in combination with [Ru3(CO)12], N‐phenyl‐2‐(dicyclohexyl‐phosphanyl)pyrrole showed the best performance. After optimization of the reaction conditions this system was applied to different secondary amines and anilines as well as a number of vicinal diols. With the exception of ethylene glycol, monoamination of the vicinal diols occurred selectively and the corresponding amino alcohols were obtained in good yields, producing water as the only side product.
Enantioseparation of cetirizine by chromatographic methods and discrimination by 1H‐NMR
Authors: Taha Elham A. , Salama Nahla N. , Wang Shudong 
Published: April 2009

AbstractCetirizine is an antihistaminic drug used to prevent and treat allergic conditions. It is currently marketed as a racemate. The H1‐antagonist activity of cetirizine is primarily due to (R)‐levocetirizine. This has led to the introduction of (R)‐levocetirizine into clinical practice, and the chiral switching is expected to be more selective and safer. The present work represents three methods for the analysis and chiral discrimination of cetirizine. The first method was based on the enantioseparation of cetirizine on silica gel TLC plates using different chiral selectors as mobile phase additives. The mobile phase enabling successful resolution was acetonitrile‐water 17: 3, (v/v) containing 1 mM of chiral selector, namely hydroxypropyl‐β‐cyclodextrin, chondroitin sulphate or vancomycin hydrochloride. The second method was a validated high performance liquid chromatography (HPLC), based on stereoselective separation of cetirizine and quantitative determination of its eutomer (R)‐levocetirizine on a monolithic C18 column using hydroxypropyl‐β‐cyclodextrin as a chiral mobile phase additive. The resolved peaks of (R)‐levocetirizine and (S)‐dextrocetirizine were confirmed by further mass spectrometry. The third method used a 1H‐NMR technique to characterize cetirizine and (R)‐levocetirizine. These methods are selective and accurate, and can be easily applied for chiral discrimination and determination of cetirizine in drug substance and drug product in quality control laboratory. Moreover, chiral purity testing of (R)‐levocetirizine can also be monitored by the chromatographic methods. Copyright © 2009 John Wiley & Sons, Ltd.
Short and Efficient Synthesis of Alkyne‐Modified Amino Glycoside Building Blocks
Authors: Klemm Claudine M. , Berthelmann Arne , Neubacher Saskia , Arenz Christoph 
Published: April 2009

AbstractIn the light of recent progress in RNA biology, the need for molecules that bind to RNA and thus may be suited to manipulating RNA‐mediated processes is steadily increasing. We present a very short and efficient synthetic route to alkyne‐modified neamine and 2‐deoxystreptamine derivatives on a half‐gram scale. These derivatives are suitable for constructing a library of potential divalent RNA binders by copper‐catalysed 1,3‐dipolar cycloaddition to diazides (“click chemistry”). The conjugate dimers thus formed inhibitedDicer‐mediated micro‐RNA maturation with IC50 values between 0.6 and 15 μM.(© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2009)
Bioactive Hydrogel Layers on Microdisk Electrode Arrays: Impedimetric Characterization and Equivalent Circuit Modeling
Authors: Rahman Abdur Rub Abdur , Justin Gusphyl , Guiseppi‐Elie Anthony 
Published: April 2009

AbstractMicrofabricated microdisk electrode arrays (MDEAs) of 50 μm (5184 disks), 100 μm (1296 disks) and 250 μm (207 disks) (d/r=4; A= 0.1 cm2) were coated with poly(hydroxyethylmethacrylate)‐based hydrogel membranes and studied by electrochemical impedance spectroscopy (EIS) in 1.0 mM ferrocene monocarboxylic acid (FcCO2H). Equivalent circuit modeling showed an approximate three‐fold increase in solution resistance, Rsol, and an order of magnitude increase in charge transfer resistance, Rct, resulting from a reduction in apparent diffusivity of FcCO2H. Additionally, both resistive parameters decreased while the capacitance (Q) increased with decreasing microdisk diameter; consistent with an increase in effective electroactive area. The hydrogel layer did not compromise enhanced mass transport achieved by the MDEA and thus may be used to advantage in biosensors.
Electrochemical Sensing of Aptamer‐Protein Interactions Using a Magnetic Particle Assay and Single‐Use Sensor Technology
Authors: Erdem Arzum , Karadeniz Hakan , Mayer Günter , Famulok Michael , Caliskan Ayfer 
Published: April 2009

AbstractA magnetic particle assay has been designed herein that can report the interactions of DNA aptamers with their cognate protein targets lysozyme (LYS) and human thrombin (THR). Electrochemical sensing of the biomolecular recognition between each aptamer and its target was explored by using a disposable graphite electrode, PGE, in combination with differential pulse voltammetry (DPV). The magnitudes of the oxidation signals of LYS and THR were measured at +780 mV and +680 mV, respectively, after interaction with the cognate aptamers attached to the surface of magnetic particles. The detection limits estimated for signal to noise ratios above 3.0 correspond to the concentrations of 10.77 μg/mL LYS (769 nM) and 2.00 μg/mL THR (54.5 nM). Our aptamer based approach that combines magnetic particles with a disposable graphite electrode performs well compared to other aptamer‐based sensor‐formats for quantitative protein detection with respect to sensitivity, selectivity, detection limit, and reproducibility.
Sensor Array: Impedimetric Label‐Free Sensing of DNA Hybridization in Real Time for Rapid, PCR‐Based Detection of Microorganisms
Authors: Ghindilis Andrei L. , Smith Maria W. , Schwarzkopf Kevin R. , Zhan Changqing , Evans David R. , Baptista António M. , Simon Holly M. 
Published: April 2009

AbstractA novel, impedance‐based electronic sensor format was used for label‐free, real‐time detection of microbial DNA on oligonucleotide probe arrays. Detection limits of 5–10 nM were achieved for single‐stranded, PCR‐amplified DNA targets. Hybridization selectivity yielded 9‐ to 12‐fold signal increases for specific targets, and the sensor arrays were re‐used multiple times without significant signal degradation. These and other features of the SHARP Laboratories of America (SLA) sensor array, such as its ability to acquire continuous measurements of DNA as it accumulates on the array surface, make it an attractive biosensor platform for field detection and monitoring of sentinel and/or pathogenic microorganisms.
Decreased expression of miR‐125b and miR‐100 in oral cancer cells contributes to malignancy
Authors: Henson Brian J. , Bhattacharjee Samsiddhi , O'Dee Dawn M. , Feingold Eleanor , Gollin Susanne M. 
Published: April 2009

AbstractAltered microRNA (miRNA) expression profiles have been observed in numerous malignancies, including oral squamous cell carcinoma (OSCC). However, their role in disease is not entirely clear. Several genetic aberrations are characteristic of OSCC, with amplification of chromosomal band 11q13 and loss of distal 11q being among the most prevalent. It is not known if the expression levels of miRNAs in these regions are altered or whether they play a role in disease. We hypothesize that the expression of miRNAs mapping to 11q are altered in OSCC because of loss or amplification of chromosomal material, and that this contributes to the development and progression of OSCC. We found that miR‐125b and miR‐100 are down‐regulated in OSCC tumor and cell lines, and that transfecting cells with exogenous miR‐125b and miR‐100 significantly reduced cell proliferation and modified the expression of target and nontarget genes, including some that are overexpressed in radioresistant OSCC cells. In conclusion, the down‐regulation of miR‐125b and miR‐100 in OSCC appears to play an important role in the development and/or progression of disease and may contribute to the loss of sensitivity to ionizing radiation. © 2009 Wiley‐Liss, Inc.
CDKN2A, NF2, and JUN are dysregulated among other genes by miRNAs in malignant mesothelioma—A miRNA microarray analysis
Authors: Guled Mohamed , Lahti Leo , Lindholm Pamela M. , Salmenkivi Kaisa , Bagwan Izhar , Nicholson Andrew G. , Knuutila Sakari 
Published: April 2009

AbstractMalignant mesothelioma (MM) is an aggressive cancer arising from mesothelial cells, mainly due to former asbestos exposure. Little is known about the microRNA (miRNA) expression of MM. miRNAs are small noncoding RNAs, which play an essential role in the regulation of gene expression. This study was carried out to analyze the miRNA expression profile of 17 MM samples using miRNA microarray. The analysis distinguished the overall miRNA expression profiles of tumor tissue and normal mesothelium. Differentially expressed miRNAs were found in tumor samples compared with normal sample. Twelve of them, let‐7b*, miR‐1228*, miR‐195*, miR‐30b*, miR‐32*, miR‐345, miR‐483‐3p, miR‐584, miR‐595, miR‐615‐3p, and miR‐885‐3p, were highly expressed whereas the remaining nine, let‐7e*, miR‐144*, miR‐203, miR‐340*, miR‐34a*, miR‐423, miR‐582, miR‐7‐1*, and miR‐9, were unexpressed or had severely reduced expression levels. Target genes for these miRNAs include the most frequently affected genes in MM such as CDKN2A, NF2, JUN, HGF, and PDGFA. Many of the miRNAs were located in chromosomal areas known to be deleted or gained in MM such as 8q24, 1p36, and 14q32. Furthermore, we could identify specific miRNAs for each histopathological subtype of MM. Regarding risk factors such as smoking status and asbestos exposure, significantly differentially expressed miRNAs were identified in smokers versus nonsmokers (miR‐379, miR‐301a, miR‐299‐3p, miR‐455‐3p, and miR‐127‐3p), but not in asbestos‐exposed patients versus nonexposed ones. This could be related to the method of assessment of asbestos exposure as asbestos remains to be the main contributor to the development of MM. © 2009 Wiley‐Liss,Inc.