bluuebunny/crossref_metadata_2025_split huggingface dataset:
Predictive models of radiographic progression and pain progression in patients with knee osteoarthritis: data from the FNIH OA biomarkers consortium project
Authors: Li Xiaoyu , Li Chunpu , Zhang Peng 
Published: May 2024

Abstract
Objectives
The progression of knee osteoarthritis (OA) can be defined as either radiographic progression or pain progression. This study aimed to construct models to predict radiographic progression and pain progression in patients with knee OA.

Methods
We retrieved data from the FNIH OA Biomarkers Consortium project, a nested case-control study. A total of 600 subjects with mild to moderate OA (Kellgren-Lawrence grade of 1, 2, or 3) in one target knee were enrolled. The patients were classified as radiographic progressors (n = 297), non-radiographic progressors (n = 303), pain progressors (n = 297), or non-pain progressors (n = 303) according to the change in the minimum joint space width of the medial compartment and the WOMAC pain score during the follow-up period of 24–48 months. Initially, 376 variables concerning demographics, clinical questionnaires, imaging measurements, and biochemical markers were included. We developed predictive models based on multivariate logistic regression analysis and visualized the models with nomograms. We also tested whether adding changes in predictors from baseline to 24 months would improve the predictive efficacy of the models.

Results
The predictive models of radiographic progression and pain progression consisted of 8 and 10 variables, respectively, with area under curve (AUC) values of 0.77 and 0.76, respectively. Incorporating the change in the WOMAC pain score from baseline to 24 months into the pain progression predictive model significantly improved the predictive effectiveness (AUC = 0.86).

Conclusions
We identified risk factors for imaging progression and pain progression in patients with knee OA over a 2- to 4-year period, and provided effective predictive models, which could help identify patients at high risk of progression.
Portulaca oleracea L seed extracts counteract diabetic nephropathy through SDF-1/IL10/PPARγ–mediated tuning of keap1/Nrf2 and NF-κB transcription in Sprague Dawley rats
Authors: Aziz Wessam M. , Ahmed Samia A. , Shaker Sylvia E. , Fayed Dalia B. , Metwally Nadia S. , Shawky Heba 
Published: May 2024

Abstract
Background & objective
: While oxidative stress is the key player driving diabetic nephropathy (DN), firm glycemic control remains the pillar prophylactic measure. Purslane was extensively described as a potent hypoglycemic and hypolipidemic agent owing to its rich content of antioxidants. Therefore, this report aimed to assess the renoprotective potentials of methanol (MO) and methylene chloride (MC) fixed oil extracts of purslane seeds in a diabetic nephropathy (DN) model.

Methods
Purslane seeds were extracted using absolute methanol and methylene chloride, and type-1 diabetes was induced with a single 55 mg/kg dose of Streptozotocin (STZ) dissolved in 100 mmol/L citrate buffer (pH 4.5), and then diabetic animals were received MO, MC, for 42 consecutive days to compare their antidiabetic effect relative to the reference drug “Losartan”. Renal functions and DN biomarkers were weekly assessed, and the relative expression of different oxido-inflammatory mediators was quantified in diabetic kidneys by RT-PCR. Data were statistically analyzed using GraphPad Prism 9.0.2.

Results
The oral administration of MO and MC extracts (250 mg/kg/day) significantly ameliorated the body weight loss (P < 0.0001 / each), fasting blood glucose levels (FBG) (P < 0.0001 / each), urine volume (P < 0.0001 / each), as well as serum creatinine (P < 0.0001 / each), uric acid (P = 0.0022, 0.0052), and blood urea nitrogen (BUN) (P = 0.0265, 0.0338); respectively, compared with the untreated diabetic rats. In addition, both extracts restored the effectuality of antioxidative machinery in diabetic kidneys as indicated by a significant reduction of ROS accumulation and lipid peroxidation; higher GSH content, and promoted activity of glutathione reductase and superoxide dismutase antioxidant enzymes (P < 0.0001 / each). Histologically, both extracts alleviated the DN-structural alterations including the glomerular congestion and tubular degeneration, with MC-treated kidneys showing near to normal architecture. The transcription profiles of all treated kidneys revealed a significantly downregulated expression of TNF-α, IL-6, Keap1 and NF-κB genes, concomitant with a significant upregulation of SDF-1, IL-10, Nrf2, HO-1, and PPARγ gene expression (P < 0.0001 / all).

Conclusion
These findings highlight the remarkable DN-prophylactic potentials of purslane extracts mediated by neutralizing the hyperglycemia-induced ROS accumulation, and circumventing the downstream inflammatory cascades, surpassing the reference angiotensin receptor blocker; i.e. Losartan.
Relationship between preoperative high triglyceride-glucose index and myocardial injury following non-cardiac surgery in advanced-age patients: a retrospective cohort study
Authors: Yao Siyi , Zhang Kai , Yang Yu , Li Zhao , Liu Chang , Meng Bingbing , Sha Xiaoling , Zhang Xiaoying , Lou Jingsheng , Fu Qiang , Liu Yanhong , Cao Jiangbei , Mi Weidong , Li Hao 
Published: May 2024

Abstract
Background
Myocardial injury after non-cardiac surgery (MINS) is a common and insidious postoperative complication. This study aimed to evaluate the relationship between the triglyceride-glucose index (TyG) and MINS in advanced-age patients.

Methods
We performed a single-center retrospective study including patients ≥ 65 years of age who underwent non-cardiac surgery. The relationship between TyG and MINS was investigated using univariate and multivariate logistic regression analyses. Multivariate logistic regression analysis involved three models: Model I adjusted for preoperative factors, Model II adjusted for surgery-related factors, and Model III adjusted for both preoperative and surgery-related factors. Propensity score matching (PSM) was used to reduce the confounding effects of covariates. Subgroup analyses were then performed to evaluate the relationship between TyG and MINS in various subsamples.

Results
A total of 7789 patients were studied, among whom 481 (6.2%) developed MINS. A cut-off value of TyG of 8.57 was determined using a receiver operating characteristic (ROC) curve to be associated with the best predictive performance. Participants with TyG ≥ 8.57 were at a higher risk of developing MINS than those with TyG < 8.57 [n = 273 (7.6%) vs. n = 208 (4.9%), respectively; p < 0.001]. The univariate analysis showed that TyG ≥ 8.57 was significantly associated with MINS in elderly patients [odds ratio (OR): 1.58; 95% confidence interval (95%CI): 1.32–1.91; p < 0.001)]. In multivariate logistic regression, adjustments were made for risk factors including age, sex, body mass index (BMI), hypertension, coronary heart disease, and duration of surgery, etc. The adjusted ORs for TyG ≥ 8.57 were 1.46 (95%CI: 1.17–1.82), p = 0.001; 1.46 (95%CI: 1.19–1.77), p < 0.001; and 1.43 (95%CI: 1.13–1.81), p = 0.003, in the three multivariate models, respectively. The relationship remained after PSM (adjusted OR: 1.35, 95% CI: 1.03–1.78, p = 0.029). Furthermore, the relationship between TyG and MINS remained in a number of subgroups in the sensitivity analyses, but not in participants with peripheral vascular stenosis.

Conclusions
A preoperative high TyG (≥ 8.57) is associated with a higher risk of MINS in advanced-age patients undergoing non-cardiac surgery.
Explanatory argumentation in natural language for correct and incorrect medical diagnoses
Authors: Molinet Benjamin , Marro Santiago , Cabrio Elena , Villata Serena 
Published: May 2024

Abstract
Background
A huge amount of research is carried out nowadays in Artificial Intelligence to propose automated ways to analyse medical data with the aim to support doctors in delivering medical diagnoses. However, a main issue of these approaches is the lack of transparency and interpretability of the achieved results, making it hard to employ such methods for educational purposes. It is therefore necessary to develop new frameworks to enhance explainability in these solutions.

Results
In this paper, we present a novel full pipeline to generate automatically natural language explanations for medical diagnoses. The proposed solution starts from a clinical case description associated with a list of correct and incorrect diagnoses and, through the extraction of the relevant symptoms and findings, enriches the information contained in the description with verified medical knowledge from an ontology. Finally, the system returns a pattern-based explanation in natural language which elucidates why the correct (incorrect) diagnosis is the correct (incorrect) one. The main contribution of the paper is twofold: first, we propose two novel linguistic resources for the medical domain (i.e, a dataset of 314 clinical cases annotated with the medical entities from UMLS, and a database of biological boundaries for common findings), and second, a full Information Extraction pipeline to extract symptoms and findings from the clinical cases and match them with the terms in a medical ontology and to the biological boundaries. An extensive evaluation of the proposed approach shows the our method outperforms comparable approaches.

Conclusions
Our goal is to offer AI-assisted educational support framework to form clinical residents to formulate sound and exhaustive explanations for their diagnoses to patients.
Impact of remote ischemic postconditioning on acute ischemic stroke in China: a systematic review and meta-analysis of randomized controlled trials
Authors: Yan Ming-Yuan , Liu Jin-Min , Wu Jing , Chang Qing 
Published: May 2024

Abstract
Objective
Acute ischemic stroke (AIS) is a significant health burden in China, affecting a sizable portion of the population. Conventional pharmacological treatments frequently fall short of desirable outcomes. Therefore, exploring alternative therapies is crucial. Remote ischemic postconditioning (RIPostC) is a noninvasive and cost-effective adjunctive therapy. This study aimed to investigate the efficacy and safety of RIPostC as an adjunctive therapy for AIS to inform clinical practice.

Methods
A comprehensive search was conducted across the PubMed, Embase, Web of Science, China National Knowledge Infrastructure (CNKI), WanFang, Weipu (VIP), and China Biology Medicine disc (CBM) databases up to October 2023. All included studies underwent bias risk assessment using the Cochrane risk-of-bias assessment tool. The primary outcome measure was the National Institute of Health Stroke Scale (NIHSS), with secondary outcomes including the Barthel index (BI), D-dimer, C-reactive protein (CRP), fibrinogen (FIB), brain-derived neurotrophic factor (BDNF), modified Rankin scale (mRS), interleukin-6 (IL-6), and tumor necrosis factor-α (TNF-α) levels. The data were analyzed using fixed-effects and random-effects models in Review Manager, with mean differences (MDs) and 95% confidence intervals (CIs) calculated for each outcome. The grading of recommendations, assessment, development, and evaluations (GRADE) approach was used to evaluate the level of evidence for each outcome measure.

Results
This meta-analysis included 38 studies, encompassing 4334 patients. Compared with the control group, the RIPostC group had significantly lower NIHSS scores, serum CRP, D-dimer, IL-6, TNF-α, and FIB levels, and increased BDNF levels. Moreover, it improved the patient’s BI and mRS scores. According to the GRADE approach, the quality of evidence for mRS was deemed “moderate,” while the NIHSS, BI, and CRP were rated as “low” quality. IL-6, TNF-α, FIB, D-dimer, and BDNF received “very low” quality ratings.

Conclusion
The findings suggest that RIPostC activates endogenous protective mechanisms, providing benefits to patients with AIS.
The association among thriving in life, quality of life, and suicidal ideation in Chinese urban older adults: the moderating effects of attitude toward own aging
Authors: Zhang Shu-e , Liu Jiang-heng , Wang Yan-ping , Wu Qun-hong , Zhang Zhong , Sun Tao , Cao De-pin 
Published: May 2024

Abstract
Background
As the global trend of population aging intensifies, the health and well-being of the older population has gradually become a focus of attention for the global community. This study assessed the status of thriving in life among Chinese urban older adults and identified its relationship with attitude toward own aging and quality of life (QoL). It also tested whether attitude toward own aging moderates the association between thriving in life and Qol or between thriving in life and suicidal ideation.

Methods
Primary data were collected through a cross-sectional survey among urban older adults from three provinces in China. They were invited to complete an anonymous survey using face-to-face interviews from December 2019 to January 2020. Data from 764 older adults were analyzed.

Results
Approximately 44.39% of participants reported positive responses toward the four domains of thriving in life. Thriving in life and attitude toward own aging had a significant association with QoL. Thriving in life was a protective factor for suicidal ideation for older adults. Moreover, attitude toward own aging moderated the association between thriving in life and QoL and that between thriving in life and suicidal ideation.

Conclusions
Chinese urban older adults were reportedly thriving in life, which contributed to increased QoL and reduced suicidal ideation. Notably, the study revealed that more positive attitudes towards own aging were associated with higher levels of thriving in life, better QoL, and reduced suicidal ideation. Targeted interventions for older adults should be devised to promote thriving in life and prevent negative attitudes of older people towards their own aging, further raising QoL and reducing suicidal ideation.
3D transesophageal echocardiographic visualization of the pulmonary artery catheter through the tricuspid valve and their position relative to the tricuspid valve leaflets
Authors: Takada Shoko , Fujimoto Tomoko , Tomita-Kobayashi Akiko , Hayashi Yukio 
Published: May 2024

Abstract
Background
The tricuspid valve is an atrioventricular valve consisting of three lobes. We used the 3D transesophageal echocardiography to visualize position of the pulmonary artery catheter at the tricuspid valve annulus and examined where the catheter passed through at the level of the tricuspid annulus.

Methods
In this prospective and observational study, we monitored the pressure wave on patients undergoing cardiac surgery with the catheter placement by monitoring the pressure waveform for 8 months. We measured the time required for the catheter to pass through the tricuspid and pulmonary valves, respectively. We acquired the 3D image of the tricuspid valve by transesophageal echocardiography and determined the position of the pulmonary artery catheter at the level of the tricuspid annulus. The data were analyzed by Kruskal-Wallis test followed by Mann-Whitney test with Holm multiple comparisons. P < 0.05 was considered significant.

Results
Of the 116 cases, the pulmonary artery catheter passed through the tricuspid valve between antero-posterior leaflets in 78 cases (67.2 %), between septal-posterior leaflets in 25 cases (21.6 %), and between antero-septal leaflets in 2 cases (1.7 %) and the center in 11 cases (9.5 %), respectively. The time required for the catheter to pass through the pulmonary valves was significantly different among the catheter positions at the level of the tricuspid annulus.

Conclusion
The pulmonary artery catheter location at the level of the tricuspid annulus can be identified using 3D transesophageal echocardiography. The location of the catheter significantly affects the pulmonary artery catheter placement time.
Extracting Electronic Health Record Neuroblastoma Treatment Data With High Fidelity Using the REDCap Clinical Data Interoperability Services Module
Authors: Furner Brian , Cheng Alex , Desai Ami V. , Benedetti Daniel J. , Friedman Debra L. , Wyatt Kirk D. , Watkins Michael , Volchenboum Samuel L. , Cohn Susan L. 
Published: May 2024

PURPOSE Although the International Neuroblastoma Risk Group Data Commons (INRGdc) has enabled seminal large cohort studies, the research is limited by the lack of real-world, electronic health record (EHR) treatment data. To address this limitation, we evaluated the feasibility of extracting treatment data directly from EHRs using the REDCap Clinical Data Interoperability Services (CDIS) module for future submission to the INRGdc. METHODS Patients enrolled on the Children's Oncology Group neuroblastoma biology study ANBL00B1 (ClinicalTrials.gov identifier: NCT00904241 ) who received care at the University of Chicago (UChicago) or the Vanderbilt University Medical Center (VUMC) after the go-live dates for the Fast Healthcare Interoperability Resources (FHIR)–compliant EHRs were identified. Antineoplastic drug orders were extracted using the CDIS module. To validate the CDIS output, antineoplastic agents extracted through FHIR were compared with those queried through EHR relational databases (UChicago's Clinical Research Data Warehouse and VUMC's Epic Clarity database) and manual chart review. RESULTS The analytic cohort consisted of 41 patients at UChicago and 32 VUMC patients. Antineoplastic drug orders were identified in the extracted EHR records of 39 (95.1%) UChicago patients and 26 (81.3%) VUMC patients. Manual chart review confirmed that patients with missing (n = 8) or discontinued (n = 1) orders in the CDIS output did not receive antineoplastic agents during the timeframe of the study. More than 99% of the antineoplastic drug orders in the EHR relational databases were identified in the corresponding CDIS output. CONCLUSION Our results demonstrate the feasibility of extracting EHR treatment data with high fidelity using HL7-FHIR via REDCap CDIS for future submission to the INRGdc.
Three Historicist Comments
Authors: Monot Pierre-Héli 
Published: May 2024

Abstract
This article discusses the politics of time in the culture wars of the 1980s by way of three comments on the discursive and political uses of the conceptual pairs historicism/otium, reform/revolution, and emergency/patience. This article argues that (1) the culture wars articulated a politically valuable dialectic of critique and the objects of critique, 2) historians tend to foreshorten their account of the culture wars and make light of their nonreformist origins, and (3) a reappraisal of the culture wars would provide precious signposts for strategic approaches to current political threats.
The Euphoria of Theory
Authors: Jones-Katz Gregory 
Published: May 2024

Abstract
In the last three decades of the twentieth century, theory became a “cognitive good” throughout the American academic humanities. The rise and uses of this new high-tech good fit the “new spirit of capitalism,” to quote Luc Boltanski and Eve Chiapello's 2018 book by the same name, a post-1960s “ideology that justifies engagement in capitalism.” A neoliberal ethos and disposition animated theory and possessed theorists, as well as spaces that circulated theory, such as the University of Minnesota's Theory and History of Literature book series, theory journals, and the University of California, Irvine's School of Criticism and Theory. Meanwhile, capitalism incorporated the nature, scope, and social effectiveness of critique by way of theory in American higher education; theorists worked in a university where neoliberal forces saturated and directed professional and intellectual protocols. The academic humanist Left's promotion of theory, for instance, facilitated the formation of the “university” as a theater for culture war conflicts, shifting attention inside and outside the academy away from underlying changes in capitalism.
Institutional Autonomy and Anticipatory Obedience
Authors: Hegeman Susan 
Published: May 2024

Abstract
This article compares episodes in two historical moments in the United States, the 1960s and the present, to interrogate how public universities have responded to culture war issues and pressure from powerful political actors. It recounts how in Florida the COVID-19 pandemic exacerbated a culture war over education and speech related to race and how the University of Florida capitulated to an ambitious governor ultimately bent on synchronizing Florida's university system to his political goals. To highlight the singularity of this episode, the article compares these events with another instance when a governor pressured university leadership over a culture war issue, during the heated era of 1960s protests over racism and imperialism. In 1969 Charles E. Young, chancellor of UCLA, publicly opposed the California regents and Governor Ronald Reagan when they sought to fire a young philosophy professor, Angela Y. Davis, over her communist party membership. Both recent events in Florida and the campaign to dismiss Davis turned on questions of academic freedom. This article explores the conditions that allowed Young to more successfully defend his university's autonomy and concludes that the privatized conception of the neoliberal university's social value makes contemporary universities particularly susceptible to political interference and antidemocratic co-optation.
Archipelagic Stories, Anguilliform Resistances
Authors: Obeegadoo Nikhita 
Published: May 2024

Abstract
This article addresses the persistent anthropocentric bias of archipelagic studies. It asks: What would it mean to invite more-than-human and transspecies perspectives into our theorizations of archipelagoes? This interrogation is addressed by following the meanderings of the eel—famously recognized as “the most mysterious creature in the natural world”—through two Francophone texts arising from the Indian Ocean: the first is Mauritian author Ananda Devi's novella La vie de Joséphin le fou (2003), and the second is Comoran author Ali Zamir's novel Anguille sous roche (2016). Through detailed literary analysis, this article demonstrates that in both prose narratives, the perspectives of marine creatures are crucial to the complete telling of intergenerational violence: in particular, the seemingly “infinite” memory and determination of eels becomes an antidote to the fragmentation caused by human trauma. Additionally, this article argues that in both texts, the anguilliform is not simply a theme but also a method, which allows for novel archipelagic forms of storytelling and memory that are as slippery and sinuous as the animals who inspire it. The eel's anguilliform movement thus becomes a source of stylistic and narrative renewal, which allows both texts to embody commentary on the ethical slipperiness of their narratives, as well as on readers’ positionality and complicity.