bluuebunny/crossref_metadata_2025_split huggingface dataset:
Optimasi peningkatan asam gamma-aminobutirat (gaba) susu fermentasi kacang gude (Cajanus cajan (L) Mill.sp) menggunakan probiotik Lactiplantibacillus plantarum Dad-13 sebagai minuman kesehatan
Authors: Suryani Ni Luh , Nursini Ni Wayan , Wita Kusumawati I Gusti Ayu , Agung Yogeswara Ida Bagus 
Published: February 2025

Background: Pigeon pea (Cajanus cajan) is a type of legumes that is underutilized and not widely consumed. The utilization of pigeon pea as GABA-fermented drink have not yet been conducted. The Enhancement of GABA in pigeon pea is carried out by probiotic Lactiplantibacillus plantarum Dad-13. The enhancement of GABA in fermented pigeon pea drink will improve their functional effect and economic value.Objectives: the aim of this study was to enhanced GABA content in fermented pigeon pea drink with various concentration of monosodium glutamate (MSG) using probiotic Lactiplantibacillus plantarum Dad-13.Methods: Randomized complete design was carried out in this study using experimental analysis. GABA content was determined using UPLC, total LAB was determined using spread plate method. Titration method was performed to determine the acidity and pH meter to determine the pH. Antioxidant capacity was determined using DPPH methodResults: The study showed a significant increase in GABA production, with the highest concentration reaching 92.07 mg/L in the treatment with 0.75% MSG. Additionally, there was an increase in the total count of lactic acid bacteria, total acidity, and antioxidant capacity, indicating an improvement in the physicochemical quality of the product. Organoleptic evaluation revealed panelists' preference for products with the addition of 0.25% and 0.75% MSG for taste, and 0% for texture.Conclusion: Fermentation of pigeon pea milk with the addition of Lactiplantibacillus plantarum Dad 13 and MSG successfully increased GABA production significantly, while also improving several aspects of the physicochemical and sensory quality of the product. These findings have important implications for the development of fermented pigeon pea milk as a new functional product enriched with GABA.
Kajian karakteristik, status gizi dan konsumsi makanan sumber protein pada ibu hamil di Kabupaten Jayapura
Authors: Bela Sarni Rante Allo , Mollet Genoveva Chatleen Copenhagenia 
Published: February 2025

Background: High-risk pregnancy occurs when a pregnant woman experiences increased health risks during pregnancy. This condition is influenced by several factors, including the mother's age being too young or too old, short gestation, frequent childbirth, and nutritional problems such as Chronic Energy Deficiency (CED). In Papua Province, the prevalence of CED in pregnant women reached 25.78%, higher than the national average. In addition, the prevalence of CED in Jayapura Regency is much higher than the national and provincial averages of 36.94%.Objectives: To investigate the age, gestational age, parity, and nutritional status of high-risk pregnant women, and to examine their consumption patterns of protein-rich foods.Methods: The type of research used is descriptive observational research with a cross-sectional design. This research was conducted at the Dosay Health Center, Waibhu Health Center, Sentani Health Center, and Harapan Health Center in Jayapura Regency, from June to August 2023. The study population included all pregnant women in the working area of the Health Center in the first and second trimesters, totaling 183 pregnant women, with a sample size of 105 pregnant women selected through purposive sampling. Data collected included the age of the pregnant women, the interval between pregnancies, parity, and nutritional status using BMI and upper arm circumference (Lila), along with dietary intake of protein sources, gathered using a Food Frequency Questionnaire. Data analysis was carried out using univariate statistical tests using SPSS 16. Results: Among 105 sample, the majority had a risk age > 35 (52,4%). Pregnancy interval > 3 years (48,6%), parity < 4 (53,1%), good nutritional status (42,9%), upper arm circumference ≥ 23,5 cm (83,8%) and diet Insufficient protein sources (78,1%).Conclusion: The percentage of pregnant women with good nutritional status is quite low (42,9%) and most have a diet lacking in protein sources (78,1%). This condition emphasizes the need for improved nutrition and health education to ensure safe pregnancy and childbirth. Keywords :Nutrition for pregnant women, protein consumption, protein sources
Upaya Pencegahan Tindakan Perundungan di SMA Muhammadiyah 3 Kota Tangerang
Authors: Mukhtarom Asrori 
Published: February 2025

Bullying is a despicable act that often occurs in schools. Bullying has a negative impact on the victim and is one of the causes of failure in the learning process in the classroom. So that bullying does not occur in schools, there must be prevention efforts. The aim of this research is to determine efforts to prevent bullying at SMA Muhammadiyah 3 Tangerang. This research uses qualitative research, collecting data using observation, interview and documentation techniques. Data analysis is used by reducing data, presenting data, and drawing conclusions. The results of this research show that efforts to prevent bullying at SMA Muhammadiyah 3 Tangerang are through socialization regarding the dangers of bullying during FORTASI activities at school, holding seminars involving students and female students as participants with the theme of bullying, teachers providing material on the dangers of bullying, especially through Education subjects. Religion and Character, holding affirmation activities in the form of sharing problems and advice aimed at influencing students to do good to each other, and making rules regarding sanctions for perpetrators of bullying. Keywords: Prevention, Bullying, SMA Muhammadiyah 3
Pendidikan Karakter Dalam Era Digital: Pengintegrasian Nilai-Nilai Moral Dalam Kurikulum Berbasis Teknologi
Authors: Qowim Agus Nur , Afif Nur , Mukhtarom Asrori , Fauziah Erna 
Published: February 2025

Character education has become increasingly crucial in addressing moral challenges in the ever-evolving digital era. This article discusses the approach of integrating moral values into technology-based curricula as a relevant and effective means of shaping students' character. The integration of moral values entails aligning ethical values throughout the curriculum, not treating them as separate subjects. Both teachers and parents play a vital role as role models who exemplify moral behavior to students. They not only teach moral values but also embody them in their daily actions, creating a consistent environment to support students' character development. In addition to traditional classroom learning, this approach encourages practical experiences such as community service, social projects, and extracurricular activities, providing students with opportunities to apply moral values in real-life situations. Continuous evaluation and feedback allow students to monitor their character development. This approach also takes into account cultural contexts and local values, respecting the diversity of moral values worldwide. Integrating moral values into technology-based curricula establishes a strong moral foundation for students to confront moral challenges in the continuously evolving digital world. This article highlights this approach as a relevant and sustainable step in shaping students' character in the digital era. Keywords: Character Education, Digital Era, Moral Values, Integration, Technology-Based Curriculum
तीन घुम्ती उपन्यासको वात्स्यायनशास्त्रीय विश्लेषण {A metaphysical analysis of the three wandering novels }
Authors: शर्मा Sharma उर्मिला Urmila 
Published: February 2025

आख्यानकार विश्वेश्वरप्रसाद कोइराला प्रथम आधुनिक मनोवैज्ञानिक कथाकार र विसङ्गतिवादी–अस्तित्ववादी विचारका उपन्यासकार हुन् । फ्रायडवादी जीवनदृष्टि र अस्तित्ववादी मान्यताका आधारमा यिनका कथा–उपन्यासहरूको अध्ययन भएको छ । यिनका कथा–उपन्यासमा प्रथम पूर्वीय मनोवैज्ञानिक चिन्तक आचार्य वात्स्यायनको कामशास्त्रीय प्रभाव पनि पाइन्छ । कोइरालाका आख्यानमा वात्स्यायन र फ्रायडका विशेषताहरूलाई तुलनात्मक रुपमा खोज र विश्लेषण गर्ने सन्दर्भमा उपन्यासमा पाइने कामसूत्रीय प्रभावको समष्टिगत खोज र अध्ययन भए पनि कुनै पनि निश्चित उपन्यास कृतिमा केन्द्रित भई विशिष्टीकृत रूपमा त्यो काम हुन सकेको छैन । यस लेखमा उनको पहिलो उपन्यास ‘तीन घुम्ती’मा कामशास्त्रीय प्रभावको खोज र विश्लेषण गरिएको छ । वात्स्यायनको कामसूत्रले कामवृत्तिको सर्वोच्चता, नारीस्वतन्त्रता, नारी यौनमनोविज्ञान, युवाकेन्द्री मनोविज्ञान, सम्भोग सिद्धान्त, आचारहीनता र कामान्धताको विरोध, नारीअस्तित्व र मातृत्वको सम्मान तथा संस्कृतिसापेक्षवादको मान्यतालाई महत्त्व दिएको छ । कोइरालाको ‘तीन घुम्ती’ उपन्यासमा यिनै वात्स्यायनसूत्रीय मान्यताहरूको प्रभाव देखिएको छ । यस अध्ययनमा वात्स्यायनको कामशास्त्रीय सिद्धान्तका आधारमा ‘तीन घुम्ती’ उपन्यासको विश्लेषण गरी निष्कर्ष दिने प्रयत्न गरिएको छ ।
Comparison of Phenotypic Methods for Detection of Aspergillus species among Clinically Suspected Pulmonary Tuberculosis Cases
Authors: Rahat Tabassum , Afroz Sadia , Sani Umme Israt Jahan , Haider Sharmin Binte , Nazrul Abul Khair 
Published: February 2025

Background: Pulmonary Aspergillosis has shown a significant rise in recent years, so its early diagnosis and laboratory detection is essential. Phenotypic methods such as, microscopy and culture remain widespread and essential tools for diagnosis of Aspergillus infection.
Objective: The objective of the study was to compare phenotypic methods, such as microscopy and culture for detection of Aspergillus species from sputum samples of clinically suspected pulmonary tuberculosis cases.
Methodology: A cross-sectional study was conducted from January 2021 to December 2021 in the Department of Microbiology of Sir Salimullah Medical College, Dhaka. A total of 176 sputum samples were collected from clinically suspected pulmonary tuberculosis patients. Mycobacterium tuberculosis was detected by Gene Xpert from the sputum sample. Aspergillus was identified by KOH mount microscopy and culture on Sabouraud’s chloramphenicol agar media with gentamicin. Species identification of Aspergillus was done by colony characteristics and lactophenol cotton blue staining using direct microscopy.
Results: In this study, out of 176 sputum samples, Mycobacterium tuberculosis was detected by Gene Xpert in 28(15.91%) sputum samples. 24(13.64%) Aspergillus species were detected by culture and 20(11.36%) were detected by microscopy. Aspergillus fumigatus 12(50%) was the commonest isolated species, followed by Aspergillus niger 7(29.17%).
Conclusion: Morphological identification systems, such as traditional culture methods and direct microscopic examination, have been always played a dominant role in Aspergillus identification.
Bangladesh Journal of Medical Microbiology, July 2024;18(2):69-74
Dampak Pengunjung Objek Wisata Jatim Park 1 Terhadap Tingkat Pengangguran Masyarakat Kota Batu
Authors: Maharani Febiyanti Putri , Sefaverdiana Putri Vina , Rakhmadian Miftah 
Published: February 2025

Penelitian ini bertujuan untuk menganalisis dampak pengunjung Jatim Park 1 terhadap tingkat pengangguran masyarakat di Kota Batu. Kota Batu, yang dikenal sebagai destinasi wisata populer, mengalami peningkatan signifikan dalam jumlah pengunjung setiap tahunnya. Dengan menggunakan metode deskriptif kuantitatif, penelitian ini mengumpulkan data sekunder diperoleh dari laporan tahunan dan Badan Pusat Statistik (BPS) Kota Batu. Hasil penelitian menunjukkan total setiap tahun pengunjung objek wisata rata-rata 434,745 orang, dan perbulan terdapat 36,229. Jumlah rata-rata pengangguran di Kota Batu sebesar 5,17 % setiap tahun, sedangkan total pengangguran setiap bulannya terdapat 0.43 %. Pengaruh pengunjung objek wisata terhadap pengangguran sebesar 0,069%. Nilai Sig. (2-tailed) sebesar 0,615 > 0,05 maka tidak berkorelasi. Nilai correlations pearson 0,263 > r tabel yaitu 0,2635 < 0,811 maka nilai signifikansi tidak berhubungan. Penelitian ini menyimpulkan bahwa peningkatan jumlah pengunjung tidak berkontribusi positif terhadap penurunan tingkat pengangguran dan peningkatan kesejahteraan masyarakat Kota Batu.
Effects of trigger-day progesterone in c-IVF/ICSI cycles on blastocyst culture outcomes
Authors: Sun Yating , Wang Jia , Zhang Luyun , Chang Yanjun , Zhu Aizhen 
Published: February 2025

ObjectiveTo assess whether trigger-day progesterone (P) levels in conventional in vitro fertilization (c-IVF)/intracytoplasmic sperm injection (ICSI) cycles are associated with blastocyst culture outcomes.MethodsIn this retrospective analysis, 747 eligible patients (747 cycles) who adopted the gonadotropin-releasing hormone (GnRH) antagonist protocol and underwent c-IVF/ICSI between January 2021 to June 2024 were recruited. The P cutoff values were 1.0 and 1.5 ng/ml when trigger-day serum P was measured, and 4177 day3 (D3) embryos for blastocyst culture were grouped according to trigger-day P levels. Furthermore, the effects of trigger-day P on blastocyst culture outcomes were evaluated.ResultsIn total, 747 cycles, 4177 D3 embryos for blastocyst culture were analyzed. After adjustments, multivariate logistic regression analysis revealed that compared with those in the normal level group, available blastocyst rate (adjusted OR, 0.780; 95% CI, 0.645-0.942; P=0.010) and D5 available blastocyst rate (adjusted OR, 0.736; 95% CI, 0.604-0.898; P=0.003) in the high level group were significantly reduced. Subgroup analysis showed that when female age was less than 35 years old, compared with that (36.30%) in the normal level group, the D5 available blastocyst rate (36.92%, adjusted OR, 0.744; 95% CI, 0.602-0.920; P=0.006) in the high level group was significantly reduced. In ICSI cycles, compared with that (28.69%) in the normal level group, the D5 available blastocyst rate (19.13%, adjusted OR, 0.369; 95% CI, 0.194-0.703; P=0.002) in the high level group was significantly decreased.Conclusion(s)This study demonstrated that in the c-IVF/ICSI population, the trigger-day slightly elevated P (1.0-1.5ng/ml) was not related to blastocyst culture outcomes, while the trigger-day elevated P (&gt;1.5ng/ml) was an important factor affecting D5 available blastocyst rate, especially when the woman was younger than 35 years old or insemination type was ICSI.
Case report: Hypoparathyroidism-sensorineural hearing loss-renal dysplasia without febrile seizures: a novel mutation in the GATA3 gene
Authors: Chen Haibin , Zhang Yudi , Yang Xueyao , Li Yongzhen 
Published: February 2025

ObjectiveThis study aims to summarize the diagnostic and treatment experience of a case of Hypoparathyroidism-Sensorineural Hearing Loss-Renal Dysplasia (HDR) syndrome caused by a heterozygous mutation in the GATA3 gene.MethodsThe diagnostic and treatment process of the patient with HDR syndrome in our hospital was compared and analyzed.ResultsA 9-month-old male infant with a history of poor physical condition and increased susceptibility to infections. At the age of 2 months, ptosis was observed in the left eye. Laboratory tests revealed decreased serum calcium, elevated blood phosphorus levels, and reduced parathyroid hormone (PTH) levels, indicating the presence of “Hypoparathyroidism”. Genetic testing identified a heterozygous mutation in the GATA3 gene in the patient, specifically a nucleotide change from G to T at position 800 (c.800G&gt;T). This mutation resulted in the substitution of cysteine with phenylalanine at amino acid position 267 (p.C267F). The missense mutation was determined to be both pathogenic and novel.ConclusionEarly genetic testing should be prioritized, and regular monitoring of kidney development and hearing status is essential. The reported case, featuring the novel GATA3 gene mutation c.800G&gt;T (p.C267F), contributes to the enrichment of the genetic database.
Association between obstructive sleep apnea hypopnea syndrome and arteriosclerosis in patients with type 2 diabetes mellitus: mediating effect of blood pressure
Authors: Wang Xinshui , Huang Xiaolin , Xing Yuexian , Jiang Xiaohong , Hua Fei 
Published: February 2025

ObjectiveThis study aims to explore the relationship between Obstructive Sleep Apnea Hypopnea Syndrome (OSAHS) and arteriosclerosis in type 2 diabetes mellitus (T2DM) patients and to evaluate the mediating effect of blood pressure in this process.MethodsA total of 411 T2DM patients admitted to the Third Affiliated Hospital of Soochow University from January 2021 to December 2023 were selected and divided into the arteriosclerosis group (n = 299) and the non-arteriosclerosis group (n = 112) based on brachial-ankle pulse wave velocity (ba-PWV). General clinical data, metabolic indicators, and sleep-related parameters were collected. The relationship between the apnea-hypopnea index (AHI) and arteriosclerosis was analyzed using univariable and multivariable logistic regression models, while a generalized additive model (GAM) was applied for curve fitting. A segmented regression model was used to explain nonlinearity, and subgroup analysis was conducted to assess interactions. Finally, a mediation effect model evaluated AHI’s direct and indirect effects on arteriosclerosis.ResultsThe AHI of the arteriosclerosis group was significantly higher than that of the non-arteriosclerosis group (P &lt; 0.001). In the unadjusted, partially adjusted, and fully adjusted regression analyses, elevated AHI significantly increased the risk of arteriosclerosis (P &lt; 0.05). Curve fitting indicated a near-linear positive correlation (P = 0.033). The segmented regression model showed that when AHI &lt; 8.8 events/hour, the risk of arteriosclerosis significantly increased with higher AHI (P = 0.008), but the risk increase was not significant when AHI &gt; 8.8 events/hour (P = 0.124). There was no significant interaction between AHI and blood pressure-related index subgroup indicators (P &gt; 0.05). Mediation analysis revealed that systolic blood pressure (SBP), diastolic blood pressure (DBP), and mean arterial pressure (MAP) had significant mediating effects on the relationship between AHI and arteriosclerosis (P &lt; 0.05), but the direct effect of AHI on arteriosclerosis was not significant (P &gt; 0.05).ConclusionOSAHS severity elevates arteriosclerosis risk in T2DM patients. Blood pressure is a partial intermediary in this effect.
Advancing early detection of organ damage and cardiovascular risk prevention: the Suzhou cardiometabolic health study protocol - exploring the role of oral microbiome and metabolic profiling in risk stratification
Authors: Zhu Mengmeng , Li Yiwen , Wang Wenting , Liu Longkun , Liu Wenwu , Yu Jiayu , Xu Qian , Cui Jing , Liu Yanfei , Chen Keji , Liu Yue 
Published: February 2025

BackgroundCardiovascular Disease (CVD) is the leading cause of global mortality, with its incidence rate rising year by year due to the prevalence of metabolic diseases. Existing primary and secondary prevention strategies for cardiovascular disease have limitations in identifying some high-risk groups, and 1.5-level prevention aims to achieve more precise intervention by early identification of subclinical target organ damage. This study introduces oral (tongue coating) microbiota as metabolic markers for the first time, in combination with multiple metabolic factors, to explore their potential in assessing subclinical target organ damage and optimizing cardiovascular risk stratification, in order to provide a new path for the early identification and intervention of CVD.MethodsThis study is a prospective cohort study aimed at assessing the association between tongue coating microbiota characteristics and multiple metabolic factors with subclinical target organ damage, and identifying high-risk groups suitable for cardiovascular 1.5-level prevention. The study will be conducted in Suzhou City, Jiangsu Province, China, planning to include 5000-6000 eligible subjects, with inclusion criteria of age ≥18 years, excluding individuals with a history of CVD and other serious diseases. Baseline assessment includes demographic information, lifestyle (including dietary patterns), medical history, physical examination, and collection of tongue coating microbiota samples. Subjects will be followed up every 2 years, with the primary outcome being the first occurrence of coronary heart disease and stroke, and the secondary outcome being subclinical target organ damage.DiscussionThis study focuses on cardiovascular 1.5-level prevention strategy, combining metabolic factors with tongue coating microbiota characteristics, aiming to optimize the risk assessment system for subclinical target organ damage. This approach can not only fill the gap in traditional risk assessment but also provide new ideas for the early identification and intervention of CVD. In the future, the feasibility and effectiveness of this strategy will be verified through multicenter studies, and it is expected to be promoted to a wider medical system, significantly improving the health management level of high-risk groups for CVD.Trial registration numberhttp://itmctr.ccebtcm.org.cn, identifier ITMCTR2024000616.
Real-world effectiveness of sofosbuvir/velpatasvir, glecaprevir/pibrentasvir, and sofosbuvir/velpatasvir/voxilaprevir against genotype 3 hepatitis C virus infection: a systematic review and meta-analysis
Authors: Zhuang Liwei , Li Junnan , Zhang Yu , Ji Shibo , Xing Huichun 
Published: February 2025

IntroductionDirect antiviral agents (DAAs) have dramatically changed the landscape of liver diseases associated with chronic hepatitis C virus (HCV) infection. However, limited data are available on the antiviral effect of sofosbuvir (SOF) + velpatasvir (VEL) ± ribavirin (RBV), SOF + VEL + voxilaprevir (VOX), and glecaprevir (GLE) + pibrentasvir (PIB) in treating patients infected with HCV GT3 in a real-world setting.MethodsUsing the EMBASE, PubMed, and Cochrane Library databases, articles were screened from 1 January 2016 to 1 June 2024. The sustained virologic response (SVR) rates were analyzed using the Freeman–Tukey double arcsine transformation in a random-effects model in R4.1.0 software.ResultsWe recruited 3,177 patients with HCV GT3 in 19 studies from 9 countries. The pooled SVR12/24 rate of the three evaluated regimens was 94.00% (95% CI: 90.87-96.59%). Furthermore, the SVR rate was 83.81% (95% CI: 75.70-90.62%) in patients receiving SOF+VEL+VOX; 94.98% (95% CI: 92.02-97.33%) in patients receiving SOF+VEL ± RBV; and 96.96% (95% CI: 93.20-99.45%) in patients receiving GLE+PIB. The pooled SVR12/24 rate of the three regimens was 95.70% (95% CI: 91.74-98.58%) and 90.50% (95% CI: 83.50-95.90%) in non-cirrhotic and cirrhotic patients, respectively. The pooled SVR rate was 96.79% (95% CI: 93.37-99.13%) and 88.41% (95% CI: 82.67-93.22%) in treatment-naive and treatment-experienced patients, respectively.ConclusionSOF+VEL ± RBV, GLE+PIB, and SOF+VEL+VOX had good antiviral effectiveness for chronic HCV-GT3 infection in real-world settings. Factors such as cirrhosis and treatment experience, especially previous DAA treatment failure, may influence the SVR rate.