bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prognostic models of drug-induced neutralizing antibody formation in patients with rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis treated with TNF-α blockersockers
Authors: Kraev Krasimir , Hristov Bozhidar , Uchikov Petar , Kraeva Mariya , Geneva-Popova Mariela , Popova Stanislava , Basheva-Kraeva Yordanka , Stoyanova Nina S. , Mitkova-Hristova Vesela 
Published: April 2024

Aim: This study aimed to construct prognostic mathematical models utilizing multifactorial regression analysis to assess the risk of developing drug-induced neutralizing antibodies in patients with rheumatoid arthritis, psoriatic arthritis, and ankylosing spondylitis treated with tumor necrosis factor alpha blockers.
Materials and methods: ﻿Over a four-year period, we enrolled 213 patients in this study and divided them into three groups: the rheumatoid arthritis group (n=121), the ankylosing spondylitis group (n=50), and the psoriatic arthritis group (n=42). The study included also a group of healthy controls consisting of 31 healthy subjects who matched the patient groups in age, sex, body mass index, and conditions typical for rheumatology patients. Prognostic mathematical models based on statistically significant factors determined through univariate correlation and regression analyses incorporated patient medical history and serological and immunological data.
Results: The study encompassed all 213 patients and 31 healthy controls. Data analysis was conducted at 12 and 24 months after commencing treatment. During this follow-up, the patients exhibited the highest percentage of antidrug antibodies. At 6 months, 6.57% of patients had confirmed neutralizing antibodies, which increased to 12.69% at 12 months and 17.72% at 24 months. Multivariate logistic regression analysis revealed that factors such as age over 55 years, excess weight, smoking, and absence of methotrexate treatment at a dose less than 7.5 mg per week had the highest predictive value.
Conclusions: Investigating clinical and biological markers with predictive value for individual patients’ therapeutic responses is a complex task. This complexity arises from the interplay of at least three distinct parameters: the patient’s disease state, drug bioavailability, and pathophysiological changes within the patient’s body, all of which are influenced by various factors.
Entre soin et théâtre, l’art en partage : la création « Paroles et parole »
Authors: Métrailler Al-Sayeg Jocelyne 
Published: April 2024

« Paroles et parole » est une petite forme théâtrale itinérante, réalisée à la suite de la rencontre d’Olivia Seigne, comédienne et metteure en scène et Jocelyne Métrailler al-Sayegh, infirmière spécialisée en soins palliatifs. Cette création souhaite offrir un espace de rencontres entre patient·e·s et professionnel·le·s pour permettre une meilleure connaissance et compréhension mutuelle et peut-être même permettre, de part et d’autre, des prises de conscience. Cette pièce interroge la place du langage dans le soin et met en évidence l’importance de l’écoute, de l’attitude corporelle et du choix des mots dans la construction de la relation thérapeutique.
Le potentiel du design thinking pour les politiques publiques : Développer les capacités créatives pour co-construire la ville inclusive avec les personnes âgées
Authors: Castro-Gonçalves Luciana , Josion-Portail Margaret , Zadra-Veil Cathy 
Published: April 2024

L’adaptation des villes au vieillissement constitue un défi majeur pour les politiques publiques bottom-up . Dans ce cadre, cette recherche s’intéresse aux adaptations des méthodes de design thinking (DT) pour permettre la participation des citoyens âgés aux dispositifs de co-construction des innovations urbaines. L’analyse de trois ateliers de créativité montre comment les facteurs liés à la préparation des ateliers (appui sur des acteurs tiers, adoption d’une configuration intergénérationnelle, sensibilisation des participants âgés quant au rôle qu’ils peuvent jouer dans la génération de solutions) et à l’atteinte des finalités du processus créatif participent au développement des capacités créatives des personnes âgées. Les résultats sont discutés sous l’angle des apports à la littérature sur le DT et sur la participation des publics vulnérables au processus créatif. Codes JEL : R580, H750, O360, O350
Une Amérique en « guerre incivile »
Authors: Mélandri Pierre 
Published: April 2024

Dans les années 1950, les différences entre républicains et démocrates semblaient se résumer à celles entre « bonnet blanc et blanc bonnet ». Aujourd’hui, elles les entraînent dans une « guerre incivile » sur presque tous les sujets. Le « grand chambardement » des sixties et les retombées de la mondialisation néolibérale se sont conjugués avec l’évolution du système électoral et du paysage médiatique pour creuser un fossé entre les deux grands partis politiques. Un fossé que l’élection de Donald Trump en 2016 n’a fait qu’approfondir et que, jusqu’à présent, Joe Biden n’a pas réussi à vraiment réduire .
Les États-Unis, fer de lance de l’économie mondiale
Authors: Bensaidani Anis , Baudchon Hélène 
Published: April 2024

Globalement, l’économie américaine se porte bien : la croissance perdure malgré le choc inflationniste et le resserrement monétaire massif engagé pour le juguler. Le taux de chômage se situe à un niveau historiquement bas. Grace à l’hégémonie du dollar et à leur leadership dans les nouvelles technologies, les États-Unis restent le fer de lance de l’économie mondiale. Certains points faibles persistent toutefois, au premier rang desquels figurent les déséquilibres extérieurs et budgétaires et les inégalités socio-spatiales. La recherche d’un renouveau industriel s’accompagne d’un retour au protectionnisme, tandis que l’essor du secteur pétrolier contrecarre les mesures en faveur de la décarbonation .
La grande stratégie américaine vers l’Asie et l’Indo-Pacifique : un bilan contrasté
Authors: Burdy Jean-Paul 
Published: April 2024

En 2011, le président Obama annonce un « pivot stratégique vers l’Asie » afin de maintenir le leadership de la puissance américaine dans une région au poids économique croissant, et face à une Chine qui devient un rival systémique. Du « pivot asiatique », les États-Unis passent ensuite au « rééquilibrage stratégique » en Indo-Pacifique. Au terme des présidences Obama, Trump et Biden, et à la veille d’une présidentielle américaine décisive, le 5 novembre 2024, le bilan de cette grande stratégie apparaît pour le moins contrasté .
Diversité des pierres dans la construction grecque antique : une approche géologique et statistique appliquée à des sites archéologiques du Golfe de Corinthe, Grèce
Authors: Vals Marilou de , Moretti Isabelle 
Published: April 2024

Cette étude est une comparaison de l’usage de la pierre dans 34 sites archéologiques de la région du Golfe de Corinthe (Grèce), en activité entre le vie et le ier siècle avant J.-C. Dans chaque site, le nombre de faciès et les proportions de chacun ont été obtenus. On observe une faible diversité de pierre (4-5) avec une prépondérance des faciès locaux et régionaux, très largement majoritaires en volume. Cependant, le site de Delphes apparait comme une exception : 13 faciès allochtones représentent presque 50 % du volume total. Ces premiers résultats montrent l’intérêt d’une approche quantitative, à pondérer avec les données historiques et la géologie locale.
Advanced Shut-Down / Start-Up Analysis for Gas Hydrate Prevention in Subsea Production Systems
Authors: Dalla L. F. R. , Zerpa L. E. , Koh C. A. 
Published: April 2024

Abstract
This study introduces an advanced method for enhancing the post-processing of transient multiphase flow simulations, explicitly addressing the determination of Cool-Down Time (CDT), the time that the production system takes to reach the hydrate region, which is crucial for managing gas hydrate flow assurance issues in offshore production systems. The post-processing functions that have been developed analyze the subcooling independently for gas, oil, and water phases, estimating the subcooling evolution over time for each phase. The effect of different shut-in types on the CDT and subcooling evolution is also discussed. Finally, the method was applied to two typical subsea satellite production tiebacks, providing several insights into gas hydrate potential risks in the system during transient operations. A reliable and detailed analysis of the subcooling evolution and cool-down time enables the design of hydrate-safe operations of subsea production systems.
Application Models of New Technologies for Autonomous Inspection and Operation of Subsea Systems
Authors: Sewald B. F. , Britto A. J. R. , Bastos M. X. , Silva. R. P. , Fagundes H. C. 
Published: April 2024

The subsea inspection plays a primary role in the integrity management of subsea assets. A wide variety of equipment, such as wet Christmas Trees (XMT), Pipes, Umbilical's, Mooring Lines and Manifolds are periodically inspected. The inspection frequency depends on the type of equipment and the boundary conditions applied to them, being usually based on the risk associated within the operation of the subsea assets.
The subsea system integrity management plan consists of activities such as visual inspections, functional test of safety valves, measurement of electrochemical potential, measurement of Pipe thickness and pressure tightness test of safety valves. These operations have been traditionally carried out by RSV vessels (ROV Support Vessel), which require around 40 people on board and up to 10m3/day of diesel. In a context of great demand for reducing POB (People on Board), and so the human exposure to risk, and also the urgency for GHG (Green House Gases) emission reduction, the market has been pushed to develop new inspection technologies.
The field operator, strategically aligned with this vision, has been supporting, through R&D projects, the development of the AUV for their challenging scenarios.
Bayesian-Based Approach in Soil Characterization for Top-Hole Design
Authors: Varady C. , Tenório J. , Silva E. , Junior E. Lima , Santos J. , Dias R. , Cutrim F. 
Published: April 2024

Abstract
This paper addresses Bayesian-based data-driven site characterization methods for estimating soil parameters used in top-hole casing design. Different models are applied to datasets of piezocone tests (CPTu) conducted in Brazilian fields and their performance is compared to some characterization techniques currently employed by the oil and gas industry. Regression models are crucial for soil characterization for top-hole casing design. Data-driven methods consist of a powerful tool for this purpose, allowing handling uncertainties originating from soil variability. This paper addresses machine learning models devoted to sparse data, namely Geotechnical lasso (Glasso) and Gaussian Process Regression (GPR) from a Bayesian perspective considering prior knowledge of site information. This approach provides statistical information on soil parameters like undrained shear strength, supporting structural analysis of wellhead systems, and conductor/surface casing strings. Datasets were collected from in-situ CPTu tests conducted in the Campos basins, in eastern Brazil. The first case study addressed primary CPTu data, including cone tip resistance, friction sleeve, and total pore pressure, to characterize undrained shear resistance as a random variable. In this context, the parameter was modeled using Phoon´s modified Bartlett test to calculate sample sizes that ensure stationarity. This approach presented relevant results in assessing the probability of failure for conductor and surface casing design based on the operator´s internal design criteria. As these applications, more robust techniques were used to improve data characterization. Glasso and GPR models are used to model parameter tendencies and evaluation of the random data. These methods differ in prior probability density functions adopted - Laplace and Gaussian, respectively - and they are compared with regression techniques widely used in design practice. All the models were trained to estimate undrained shear resistance. Preliminary results confirm that the technique improves the characterization of soil strata and undrained shear strength, with a beneficial effect on the analysis of offshore top-hole structural design cases. Some metrics such as Mean Absolute Error (MAE) and Root Mean Squared Error (RMSE) indicate that GPR outperforms other methods. This is an innovative methodology applied in real-case scenarios with data ceded from the partner operator. The formulation evaluates uncertainties associated with the spatial heterogeneity of the material, continuously improving robustness with each new project data. This enables a better understanding of soil behavior in specific oilfields and can assist the decision-making process in well design, improving operational safety. Furthermore, the results of the statistical modeling support reliability-based analysis to deliver probability-based indicators for well integrity design.
Automating Prediction of the Formation Tops and Lithology Changes in Real-Time While Drilling Using Artificial Neural Networks
Authors: Mahmoud Ahmed Abdulhamid , Elkatatny Salaheldin , Abdulraheem Abdulazeez 
Published: April 2024

AbstractDetermining formation tops in hydrocarbon wells is a critical aspect of drilling operations, impacting decisions related to casing setting depths and drilling fluid design. Traditionally, estimates are made based on geological data during the exploration phase, but these lack precision. Real-time updates to formation tops occur as new wells are drilled, incorporating data from various measurements like Rate of Penetration (ROP), gamma ray, formation cuttings, and mud logging. However, these measurements come with limitations such as high costs, manpower requirements, and time or depth lags.This study introduces an innovative alternative using Artificial Neural Networks (ANNs) to accurately predict formation tops. The ANNs model incorporates drilling mechanical parameters and ROP to address limitations in existing techniques, aiming to predict genuine ROP changes irrespective of other drilling parameter fluctuations. Real-field data from two Middle Eastern vertical oil wells was utilized to validate this approach. The study explored different smoothing techniques and identified the moving average technique with a span of 5 as effective in smoothing data while preserving structure.The ANNs model was trained with 70% of Well-A’s data and tested on the remaining 30%, with validation using Well-B data. The sensitivity analysis revealed that an ANNs model with 25 neurons and one hidden layer, using the trainlm training function, achieved optimal results. For testing data from Well-A and the validation date of Well-B, correlation coefficients (R) were 0.94 and 0.98, respectively. This innovative approach offers a cost-effective solution, overcoming challenges associated with traditional methods. It provides accurate, real-time predictions for formation tops during well drilling, ensuring better decision-making in casing programs and drilling fluid design, ultimately contributing to more efficient and cost-effective well operations.
Wet Christmas Tree – New Approach to Model Next Generation Control and Monitoring Systems
Authors: Pozzani D. , Kotsugai A. , Rabello A. , Silva A. H. , Coelho E. , Borda F. G. , de Souza M. A. , Carvalho L. O. , Beppler R. V. 
Published: April 2024

Abstract
This initial proposition presents a conceptual design regarding the upcoming aspects of a standardized wet Christmas tree (WCT) with electrification aspects. The study comprises not only fail safe close electrical actuators and its control system but also integration aspects, leading to an analysis of the complete system. The objective is to conceptualize a standardized electrical WCT system with quality and suitability equivalent to those of the standard electrical/hydraulic multiplexed control (EHMUX) WCT system applied in Brazilian Pre-Salt fields.
The use of a standardized Pre-Salt WCT, is the key to have time and cost reduction on a new WCT system, based on a 10 years’ experience in operating on Pre-Salt Basin conditions. The EHMUX system has proved the efficiency and is a robust system able to operate in 2500m depth and 10000psi, with high carbonic gas concentration. Therefore, the main idea is to use this platform to a conversion to a high reliability electrical WCT system with Fail Safe Close, using a new electrical actuator qualification program. One of the most important features of a new electrification system must having is a capacity to transduce production or injection conditions into readable variables where this set of information will be useful either to monitor, control and estimate other information such as life cycle considerations (e.g., maintenance), components or subsystems deterioration, and equipment’s life extension.
A System of Connected Digital Twins with Artificial Intelligent Solutions - The Key to Resolving the Energy Trilemma
Authors: Hansen O. H. , Jaiswal V. , Eriksson K. 
Published: April 2024

Abstract
For many years, the energy industry has faced the energy trilemma, implying a need to prioritize between: secure, clean, and affordable energy. Balancing the energy trilemma has always been a challenge, but the geopolitical situation since the war in Ukraine has forced the world to prioritize energy security. As a result, clean and affordable energy have taken the backseat. Solving the trilemma could make the world’s energy systems more volatile, unpredictable, and complex. The need today is to accelerate the digital transformation of the energy systems and establish a system of connected digital twins with trustworthy Artificial Intelligence (AI) solutions to go towards net zero in an affordable way.
Anchor Project: Best Practices and Lessons from Detailed Design Through Fabrication of the Anchor FPU
Authors: Falcon R. , Braun C. , Klaus K. , Shinde S. , Wu G. , Rodriguez I. 
Published: April 2024

Abstract
The Anchor semi-submersible floating production unit (FPU) is a Chevron operated Gulf of Mexico (GOM) deepwater facility with a nameplate capacity of 75,000 bopd and 28 mmscfd and future expansion capability. This paper provides an overview of the FPU from detailed design through fabrication including design philosophy, equipment selection, pre-investment, and construction methodology as well as insights into Anchor’s contracting and execution strategy. Principles such as minimum functional objective (MFO), conditions precedent (CP), and on-ground max are discussed, as are some of the key decisions that enabled successful delivery of the Anchor FPU such as early contractor engagement and implementation of a rigorous weight management program. Final investment decision (FID) for the Anchor project was reached in 4Q2019 and soon after in early 2020, the world began to experience impacts from the COVID-19 global pandemic. Actions taken by the Anchor project team to address the many challenges of executing a major capital project (MCP) during a global pandemic and market downturn will also be shared.
Anchor followed a general contracting strategy similar to past projects executed by Chevron in the GOM. While this approach requires a larger Owner’s team to manage multiple contracts and interfaces, it also provides greater visibility and earlier recognition of potential execution challenges thereby enabling the project team to react faster with direct input to mitigate or address issues as soon as they are identified. A large number of contracts were executed to deliver the FPU including separate topsides engineering, hull engineering, topsides fabrication and integration, hull fabrication, and systems completion contracts. The Anchor hull was fabricated in South Korea and transported via a heavy transport vessel to the Anchor topsides fabrication site in the US Gulf Coast where the topsides was integrated to the hull. Construction was completed in May 2023 and the Anchor FPU was wet towed from the fabrication yard to its final location in the GOM for installation and execution of the offshore hookup & commissioning (HUC) campaign.
For clarity, the following terms are used throughout this paper. High Pressure High Temperature (HPHT) refers to equipment rated to pressures greater than 15,000 psi and/or temperatures equal to or greater than 350°F. Anchor is a high pressure project under the HPHT category. 20K refers to the Anchor project’s technology development and qualification program.
Probabilistic Lateral Buckle Formation for Three Deepwater HPHT Pipeline Mitigations
Authors: Valer C. I. , Bai Q. , Cardoso P. , Jebali A. , Almeida R. , Mendes A. 
Published: April 2024

AbstractA comparison assessment of lateral buckle (LB) formation among three typical buckle mitigation devices (sleeper, distributed buoyancy modules (DBM), and residual curvature method (RCM)) commonly considered in the design of high pressure and high temperature (HPHT) flowlines is carried out by adopting a probabilistic approach based on Virtual Anchor Spacing Finite-Element (VAS FE) modeling to assess buckle initiation reliability. The pros and cons of each device are detailed, the critical stochastic parameters and deterministic parameters for the buckle formation associated with each device are identified, and a probabilistic assessment via a case study is carried out using the three mitigation devices for a subsea deep-water HPHT production flowline.The probabilistic assessment of pipeline lateral buckling includes the following: (1) Calculation of the critical buckling force (CBF) and its probability density function for both engineered and rogue buckles based on deterministic and stochastic parameters via Monte-Carlo simulation and design of experiments (DOE); (2) Determination of the tolerable VAS by FE analyses for both engineered and rogue buckles to satisfy the design criteria; (3) Positioning of the engineered buckles along the flowline through a reliability analysis using BUCKFAST.The analysis results indicate that the stochastic parameters that control the buckling formation are different for each of the three mitigation methods. Comparison of the three methods showed that the RCM option had the most significant impact on reducing the CBF due to the influence of the pipe/soil lateral breakout friction factor while the DBM option had the least significant impact, with the highest CBF among the studied mitigation devices. Results also show that some of the stochastic parameters do not have significant effects on the CBF for each considered mitigation device and therefore could be treated as deterministic parameters in future analyses. The competition between the CBF of rogue buckles along the curve section and the trigger CBF distribution is the key parameter when comparing the different mitigation methods. Sleeper and DBM options may not satisfy the LB design criteria in some cases when using the deterministic approach, especially for a rough seabed profile along the route, but may lead to a solution when using a probabilistic assessment. RCM has the advantages of a lower CBF and the lowest cost among the three mitigation methods, which means the RCM is a cost-effective lateral buckle mitigation solution for subsea HPHT pipelines.