bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evidence for acute neurotoxicity after chemotherapy
Authors: Petzold Axel , Mondria Tjeerd , Kuhle Jens , Rocca Maria A. , Cornelissen Jan , te Boekhorst Peter , Lowenberg Bob , Giovannoni Gavin , Filippi Massimo , Kappos Ludwig , Hintzen Rogier 
Published: December 2010

AbstractObjectiveChronic neurotoxicity is a recognized long‐term complication following chemotherapy in a range of diseases. Neurotoxicity adversely affects patients' quality of life. The objective of this study is to examine whether there is evidence of acute neurotoxicity.MethodsThis prospective study included patients with secondary progressive multiple sclerosis (SPMS‐BMT, n = 14) and hematological malignancies (HM‐BMT, n = 17) receiving chemotherapy as preconditioning for bone marrow transplant. The control groups included SPMS patients matched for demographic and clinical data (SPMS‐PL, n = 14) and healthy controls (n = 14). Neurodegeneration was assessed at baseline and longitudinally (months 1, 2, 3, 6, 9, 12, 24, and 36), combining a clinical scale for disability (Expanded Disability Status Scale [EDSS]), a serum protein biomarker for neurodegeneration (neurofilaments, NfH‐SMI35), and brain atrophy measures (magnetic resonance imaging).ResultsDisability progression was significantly more acute and severe following chemotherapy compared to placebo. Immediately after starting chemotherapy, serum NfH‐SMI35 levels increased in 79% (p< 0.0001) of SPMS‐BMT patients and 41% (p< 0.01) of HM‐BMT patients compared to 0% of SPMS‐PL patients or healthy controls. In SPMS‐BMT serum NfH‐SMI35 levels were > 100‐fold higher 1 month after chemotherapy (29.73ng/ml) compared to baseline (0.28ng/ml,p< 0.0001). High serum NfH‐SMI35 levels persisting for at least 3 months were associated with sustained disability progression on the EDSS (p< 0.05). Brain atrophy rates increased acutely in SPMS‐BMT (−2.09) compared to SPMS‐PL (−1.18,p< 0.05).InterpretationNeurotoxicity is an unwanted acute side effect of aggressive chemotherapy. ANN NEUROL 2010
The authorship lottery: An impediment to research collaboration?
Authors: Kaufmann Petra , Annis Christine , Griggs Robert C. ,   and the Muscle Study Group Executive Committee
Published: December 2010

AbstractAuthorship of scientific publications holds great importance for basic and clinical researchers. Academic appointments and promotions, grant funding, and salary support depend to some extent on published recognition through authorship. Peer‐recognition and personal satisfaction are additional incentives for authorship. Some current “rules” and conventions for assigning authorship are based on largely unwritten but widely‐accepted arbitrary decisions. We hypothesize that the inherent uncertainties about assigning “credit where credit is due” serve as a disincentive for clinicians considering an academic career and may discourage or at least impede the collaborations essential to address most translational and clinical research issues. Surveys of the New England Journal of Medicine and the Annals of Neurology suggest that neurologists have been slow to adopt ways of sharing “credit” appropriately. We recommend that authorship of reports of the primary results of multicenter or multidisciplinary studies should be in the name of the group of investigators collaborating on the work. Given the availability of digital methods that could apportion credit quantitatively, academic leaders, including funding agencies and promotions committees, should consider challenging outmoded authorship conventions. Authorship is too important to be left to chance. Ann Neurol 2010;
ChemInform Abstract: New Intermetallics YbAu2In4 and Yb2Au3In5.
Authors: Sebastian C. Peter , Salvador James , Martin Joshua B. , Kanatzidis Mercouri G. 
Published: December 2010

AbstractSingle crystals of the new title compounds are prepared in high yields from the elements using excess In as a flux (1000 °C, 5—72 h).
ChemInform Abstract: Crystal Structure and Physical Properties of Quaternary Clathrates Ba8ZnxGe46‐x‐ySiy, Ba8(Zn,Cu)xGe46‐x and Ba8(Zn,Pd)xGe46‐x.
Authors: Nasir Navida , Grytsiv Andriy , Melnychenko‐Koblyuk Nataliya , Rogl Peter , Bednar Ingeborg , Bauer Ernst 
Published: December 2010

AbstractSemiconducting clathrate‐type I compounds are of considerable interest for thermoelectric materials.
ChemInform Abstract: High‐Yield Synthesis of Ultralong and Ultrathin Zn2GeO4 Nanoribbons Toward Improved Photocatalytic Reduction of CO2 into Renewable Hydrocarbon Fuel.
Authors: Liu Qi , Zhou Yong , Kou Jiahui , Chen Xiaoyu , Tian Zhongping , Gao Jun , Yan Shicheng , Zou Zhigang 
Published: December 2010

AbstractSingle‐crystalline nanobelts of the title compound with lengths of hundreds of micrometers, thickness as small as ≈7 nm, and aspect ratios of up to 10000 are solvothermally synthesized in high yields from a mixture of GeO2 and Zn(OAc)2 in an en/H2O (2:1) mixed solvent (autoclave, 180 °C, 24 h).
ChemInform Abstract: Exopericyclic Stereocontrol in Johnson—Claisen Rearrangements of Allylic Sulfides.
Authors: Craig Donald , Harvey John W. , O'Brien Alexander G. , White Andrew J. P. 
Published: December 2010

AbstractThe selectivity of the Johnson—Claisen rearrangement of allylic sulfides is highly dependent on the allylic substitution pattern.
ChemInform Abstract: Development of a New Lewis Base‐Tolerant Chiral LBA and Its Application to Catalytic Asymmetric Protonation Reaction.
Authors: Cheon Cheol Hong , Imahori Tatsushi , Yamamoto Hisashi 
Published: December 2010

AbstractThe new system efficiently catalyzes the asymmetric protonation of silyl enol ethers of 2‐substituted cyclic ketones.
ChemInform Abstract: Cyanation of Arenes via Iridium‐Catalyzed Borylation.
Authors: Liskey Carl W. , Liao Xuebin , Hartwig John F. 
Published: December 2010

AbstractThe first copper‐mediated oxidative cyanation of arylboronate esters [freshly prepared by borylation of the arenes (I)] or of arylboronic acids such as (IV) or (VI) is reported to proceed with great functional group tolerance.
ChemInform Abstract: The Influence of Phosphane Ligands on the Versatility of Ruthenium—Indenylidene Complexes in Metathesis.
Authors: Broggi Julie , Urbina‐Blanco Cesar A. , Clavier Herve , Leitgeb Anita , Slugovc Christian , Slawin Alexandra M. Z. , Nolan Steven P. 
Published: December 2010

AbstractFive novel Ru‐indenylidene complexes (Ia‐e) are prepared and investigated as pre‐catalysts in ring‐closing metathesis (RCM) of dienes and enynes, ring‐rearrangement metathesis (RRM), cross metathesis (CM) and ring‐opening metathesis polymerization (ROMP, not shown).
ChemInform Abstract: Palladium‐Catalyzed Sonogashira Coupling of Aryl Mesylates and Tosylates.
Authors: Choy Pui Ying , Chow Wing Kin , So Chau Ming , Lau Chak Po , Kwong Fuk Yee 
Published: December 2010

AbstractFirst time, the present new and general method for Sonogashira coupling reactions of (hetero)aryl tosylates is successfully applied to aryl mesylates.
ChemInform Abstract: 2‐Aminophenols Containing Electron‐Withdrawing Groups from N‐Aryl Hydroxylamines.
Authors: Porzelle Achim , Cooper Anthony W. J. , Woodrow Michael D. , Tomkinson Nicholas C. O. 
Published: December 2010

AbstractTreatment of various hydroxylamines with either sulfonyl chlorides or Tf2O under the conditions shown results in formation of rearranged 2‐aminophenol derivatives.
ChemInform Abstract: Copper‐Catalyzed Synthesis of α‐Amino Imides from Tertiary Amines: Ugi‐Type Three‐Component Assemblies Involving Direct Functionalization of sp3 C—Hs Adjacent to Nitrogen Atoms.
Authors: Ye Xin , Xie Chunsong , Pan Yuanyuan , Han Laihong , Xie Tian 
Published: December 2010

AbstractThe title compounds are suitable for a broad field of applications.
ChemInform Abstract: Simple and Highly Efficient Procedure for Conversion of Aldoximes to Nitriles Using N‐(p‐Toluenesulfonyl) Imidazole.
Authors: Rad Mohammad Navid Soltani , Khalafi‐Nezhad Ali , Behrouz Somayeh , Amini Zohreh , Behrouz Marzieh 
Published: December 2010

AbstractThe efficient, stable, neutral and cheap reagent allows high‐yield conversions of aldoximes to nitriles.
ChemInform Abstract: Magnesium Chloride‐Catalyzed Thiolysis of Epoxides: Synthesis of β‐Hydroxy Sulfides.
Authors: Rani Rashmi , Pattanayak Shankha , Agarwal Jyoti , Peddinti Rama Krishna 
Published: December 2010

AbstractA mild and efficient method for the preparation of the title compounds (III) and (V) using a nontoxic, stable and inexpensive catalyst is developed.
ChemInform Abstract: Asymmetric Palladium‐Catalyzed Carboamination Reactions for the Synthesis of Enantiomerically Enriched 2‐(Arylmethyl)‐ and 2‐(Alkenylmethyl)pyrrolidines.
Authors: Mai Duy N. , Wolfe John P. 
Published: December 2010

AbstractEnantioselectivities up to 93% e.e.
ChemInform Abstract: Efficient Synthesis of 5‐Substituted 2,3‐Diphenyl and 5‐Substituted 1‐Aryl‐2,3‐diphenyl Imidazoles Using Polyethylene Glycol.
Authors: Das Biswanath , Sudhakar Chithaluri , Srinivas Yallamalla 
Published: December 2010

AbstractThe procedure is carried out in a biologically tolerable, inexpensive and ecofriendly polymer without an additional catalyst and solvent.
ChemInform Abstract: Asymmetric Organocatalytic Michael Addition of Azlactones to cis‐1,2‐Bis(phenylsulfonyl)ethene. A Simple Entry to Quaternary α‐Amino Acids.
Authors: Bravo Natalia , Alba Andrea‐Nekane R. , Valero Guillem , Companyo Xavier , Moyano Albert , Rios Ramon 
Published: December 2010

AbstractA new, practical and enantioselective entry to direct precursors of quaternary α‐alkyl‐α‐amino acids is developed.
ChemInform Abstract: Synthesis of Heterocycles on the Basis of Products of Arylation of Unsaturated Compounds. Part 22. 3‐Aryl‐2‐chloropropanal in the Synthesis of N‐Aryl‐5‐(R‐benzyl)‐1,3‐thiazole‐2‐amines
Authors: Matiychuk V. S. , Obushak N. D. , Pidlypnyi N. I. , Ostapiuk Yu. V. , Voloshchuk R. M. 
Published: December 2010

Abstract15 examples
ChemInform Abstract: Cyclization vs. Elimination Reactions of 5‐Aryl‐5‐hydroxy 1,3‐Diones: One‐Pot Synthesis of 2‐Aryl‐2,3‐dihydro‐4H‐pyran‐4‐ones.
Authors: Khera Rasheed Ahmad , Ahmad Rasheed , Ullah Ihsan , Abid Obaid‐Ur‐Rahman , Fatunsin Olumide , Sher Muhammad , Villinger Alexander , Langer Peter 
Published: December 2010

AbstractAn efficient procedure is elaborated for the synthesis of dihydropyranones (III) from readily available diketones (I).
ChemInform Abstract: Microwave‐Enhanced Synthesis of 2,3,6‐Trisubstituted Pyridazines: Application to Four‐Step Synthesis of Gabazine (SR‐95531).
Authors: Gavande Navnath , Johnston Graham A. R. , Hanrahan Jane R. , Chebib Mary 
Published: December 2010

AbstractAn efficient and versatile protocol for the synthesis of diversified 2,3,6‐trisubstituted pyridazines under microwave irradiation is developed.
ChemInform Abstract: One‐Pot, Three‐Component Synthesis of 2,3‐Dihydroquinazolin‐4(1H)‐ones Using p‐Toluenesulfonic Acid—Paraformaldehyde Copolymer as an Efficient and Reusable Catalyst.
Authors: Saffar‐Teluri Ali , Bolouk Shiva 
Published: December 2010

AbstractThe title catalyst can be recycled and reused for several runs without any decrease in its efficiency.
ChemInform Abstract: Synthesis and Biological Activity of Some New 1,3‐Thiazolyl‐6‐bromoquinazolin‐4(3H)ones.
Authors: Patel N. B. , Patel J. N. 
Published: December 2010

AbstractA variety of the title quinazolinone derivatives (V) (15 examples) is synthesized and evaluated for their antimicrobial activity.
ChemInform Abstract: Enantioselective Synthesis of trans‐Aryl‐ and ‐Heteroaryl‐Substituted Cyclopropylboronates by Copper(I)‐Catalyzed Reactions of Allylic Phosphates with a Diboron Derivative.
Authors: Zhong Chongmin , Kunii Shun , Kosaka Yuki , Sawamura Masaya , Ito Hajime 
Published: December 2010

AbstractThe title reaction of the (Z)‐configurated allylic phosphates (I) to give the trans‐configurated cyclopropanes (III) shows excellent diastereoselectivity and good functional group compatibility.
ChemInform Abstract: Copper‐Catalyzed Domino Silylative Aldol Reaction Leading to Stereocontrolled Chiral Quaternary Carbons.
Authors: Welle Alexandre , Petrignet Julien , Tinant Bernard , Wouters Johan , Riant Olivier 
Published: December 2010

AbstractA copper‐catalyzed domino silylation—aldol reaction is presented between enoyloxazolidinones (I) and (VII), various aromatic aldehydes and silylboronate (III).
ChemInform Abstract: Tellurium‐Containing Heterocycles. Part 32. Regioselective Electrophilic Cyclization of o‐Ethynylbenzyl Phenyl Selenides to (Z)‐1‐Methylidene‐2‐phenyl‐1,3‐dihydro‐1H‐benzo[c]selenophenium Salts.
Authors: Sashida Haruki , Nakabayashi Shoko , Suzuki Hirokazu , Kaname Mamoru , Minoura Mao 
Published: December 2010

AbstractThe reaction of selenium substrates proceeds under mild conditions to give (Z)‐isomers as sole or main products.
ChemInform Abstract: Search for New Natural Leads. Part 10. Cytotoxic Cycloartane Triterpene and Rare Isomeric Bisclerodane Diterpenes from the Leaves of Polyalthia longifolia var. pendula.
Authors: Sashidhara Koneni V. , Singh Suriya P. , Kant Ruchir , Maulik Prakas R. , Sarkar Jayanta , Kanojiya Sanjeev , Kumar K. Ravi 
Published: December 2010

AbstractLongitriol (I), a rare bisclerodane imide, longimide A (II) and previously known longimide B are isolated from the leaves of Polyalthia longifolia var.
ChemInform Abstract: Functionalized N‐Propargylanabazine Derivatives.
Authors: Mavrov M. V. , Zlotin S. G. 
Published: December 2010

AbstractA variety of functionalized N‐propargylanabasine derivatives, useful precursors of new biologically active anabasine‐based compounds, is synthesized by three‐component condensation reactions of anabazine hydrochloride (I) with paraformaldehyde and terminal alkynes.
ChemInform Abstract: Synthesis and Characterization of Novel Color Chemosensors Based on Azo Dyes for Possible Application in Opioid Pharmacology.
Authors: Genady Afaf R. 
Published: December 2010

AbstractCoupling of morphine and 6‐acetylmorphine with aromatic diazonium salts gives novel azo dye derivatives (I) and (II) in good yields.
ChemInform Abstract: New Nonadride Analogues from a Freshwater Isolate of an Undescribed Fungus Belonging to the Order Pleosporales
Authors: Hosoe Tomoo , Gloer James B. Gloer James B. , Wicklow Donald T. , Raja Huzefa A. , Shearer Carol A. 
Published: December 2010

Abstractisolation, structure elucidation and antifungal activities of three new nonadride derivatives (I) and two new compounds, waquafranone A (II) and B (III)
ChemInform Abstract: Design, Synthesis and Insecticidal Evaluation of Novel Pyrazolecarboxamides Containing Cyano Substituted N‐Pyridylpyrazole.
Authors: Liu Zhili , Feng Qi , Xiong Lixia , Wang Mingzhong , Li Zhengming 
Published: December 2010

AbstractTitle compounds (I) are prepared by classical synthetic methods and screened for insecticidal activity against the oriental armyworm (Mythimna separata).
ChemInform Abstract: Adamantyl‐1 and Adamantyl‐2 Imidazoles and Benzimidazoles. Methods of Synthesis, Properties and Biological Activity
Authors: Zurabishvili D. S. , Lomidze M. O. , Trapaidze M. V. , Samsoniya Sh. A. 
Published: December 2010

AbstractReview: 134 refs.
Adsorptive Water Removal from Organic Solvents in the ppm‐Region
Authors: Pahl Christoph , Pasel Christoph , Luckas Michael , Bathen Dieter 
Published: December 2010

AbstractHighly pure organic solvents gain more and more importance in optical, electronical, pharmaceutical and chemical industry. In this context the removal of water in the lower ppm‐ and ppb‐range is a major challenge since water is always present, e. g., air humidity, and leads to catalyst poisoning and undesired side reactions. One technique to remove water is by adsorption on zeolites, silica gels or aluminas. Despite single technical solutions already existing, systematic measurements of influencing parameters are still missing. The research project adresses the adsorption of water from different organic solvents. In the following experiments with linear primary alcohols and acetic acid esters are discussed as these solvents are often used in industry in low water content qualities.
Colour scheme supporting technique based on hierarchical scene structure for exterior design of urban scenes in 3D
Authors: Chin Seongah 
Published: December 2010

AbstractIn this article, we propose a method for supporting colour schemes for the exterior colour design of an urban scene in 3D and report on a user study for validating the proposed scheme. The realized simulator allows users to develop harmonized colouring schemes for an urban colour design in 3D with the selection of a dominant colour and subcolours automatically. The technical aspects include designing a colour scheming table based on a colour guideline, extracting the façade colour from an image collected from a real scene, and conducting colour scheming on a 3D scene. The proposed method enhances efficiency with respect to reducing processing cost as providing automatic colour scheme in 3D. In addition, the 3D simulator makes the proposed method interactive, which in turn increases the flexibility for manipulation of 3D simulated scenes by changing viewpoints by rotating, zooming, and navigating the simulator. The experimental results and a user study are presented. © 2010 Wiley Periodicals, Inc. Col Res Appl, 2010.
Novel automated three‐dimensional genome scanning based on the nuclear architecture of telomeres
Authors: Klewes Ludger , Höbsch Clemens , Katzir Nir , Rourke David , Garini Yuval , Mai Sabine 
Published: December 2010

AbstractTelomeres, the end of chromosomes, are organized in a nonoverlapping fashion and form microterritories in nuclei of normal cells. Previous studies have shown that normal and tumor cell nuclei differ in their 3D telomeric organization. The differences include a change in the spatial organization of the telomeres, in telomere numbers and sizes and in the presence of telomeric aggregates. Previous attempts to identify the above parameters of 3D telomere organization were semi‐automated. Here we describe the automation of 3D scanning for telomere signatures in interphase nuclei based on three‐dimensional fluorescentin situhybridization (3D‐FISH) and, for the first time, define its sensitivity in tumor cell detection. The data were acquired with a high‐throughput scanning/acquisition system that allows to measure cells and acquire 3D images of nuclei at high resolution with 40× or 60× oil and at a speed of 10,000–15,000 cells h−1, depending on the cell density on the slides. The automated scanning, TeloScan, is suitable for large series of samples and sample sizes. We define the sensitivity of this automation for tumor cell detection. The data output includes 3D telomere positions, numbers of telomeric aggregates, telomere numbers, and telomere signal intensities. We were able to detect one aberrant cell in 1,000 normal cells. In conclusions, we are able to detect tumor cells based on 3D architectural profiles of the genome. This new tool could, in the future, assist in patient diagnosis, in the detection of minimal residual disease, in the analysis of treatment response and in treatment decisions. © 2010 International Society for Advancement of Cytometry.
Ring‐Opening Reaction of Vinylidenecyclopropanediesters Catalyzed by Re2(CO)10 or Yb(OTf)3
Authors: Wu Lei , Shi Min 
Published: December 2010

AbstractRing‐opening reaction of vinylidenecyclopropanediesters catalyzed by Re2(CO)10 or Yb(OTf)3 afforded 2H‐pyran‐2‐one derivatives or α,β‐unsaturated ketones in moderate to good yields through a highly regioselective carbon–carbon bond cleavage pathway. The substituents at the cyclopropane mainly determine the regioselectivity of the carbon–carbon bond cleavage, providing different products of tandem ring‐opening and rearrangement reactions.
Synthesis of 2‐Amino‐3‐cyano‐4H‐chromene‐4‐carboxamide Derivatives by an Isocyanide‐Based Domino Conjugate Addition/O‐Trapping Rearrangement Sequence
Authors: Gyuris Márió , Madácsi Ramóna , Puskás László G. , Tóth Gábor K. , Wölfling János , Kanizsai Iván 
Published: December 2010

AbstractAn efficient, one‐pot domino synthesis of new 2‐amino‐3‐cyano‐4H‐chromene‐4‐carboxamide derivatives has been developed by the acid‐induced conjugate addition of isocyanides to 2‐imino‐2H‐chromene‐3‐carboxamides, followed by an intramolecular O‐trapping rearrangement, with yields up to 92 %. This newly established protocol was also used in multicomponent (3CR) mode.
Poly(dimethylsiloxane) photonic microbioreactors based on segmented waveguides for local absorbance measurement
Authors: Demming Stefanie , Vila‐Planas Jordi , Aliasghar Zadeh Sobehir , Edlich Astrid , Franco‐Lara Ezequiel , Radespiel Rolf , Büttgenbach Stephanus , Llobera Andreu 
Published: December 2010

AbstractWe present the development of microbioreactors (MBRs) based on poly(dimethylsiloxane) (PDMS) segmented waveguides (SWG) for local absorbance measurements. Two different MBRs were studied, either using symmetric or asymmetric SWG (being defined as MBR‐S and MBR‐A, respectively). Their optical and fluidic performances were numerically analyzed, showing robustness from an optical point of view and distinct fluid flow profile. The optical characterization was done in two steps. Initially, the experimental limit of detection (LOD) and the sensitivity were determined for two different analytes (fluorescein and methylorange). With both systems, a similar limit of detection for both analytes was obtained, being in the micromolar level. Their sensitivities were 20.2±0.3 (×10−3) A.U./μM and 5.5±0.2 (×10−3) A.U./μM for fluorescein and methylorange, respectively. Once validated its applicability for local absorbance measurements, a continuous cultivation of Saccharomyces cerevisiae was done to test the viability of the proposed systems for photonic MBRs. Concretely, the cell growth was locally monitored inside the MBR during 33 h. Spectral analysis showed that the determination of the culture parameters were wavelength dependant, with a growth rate of 0.39±0.02 h−1 and a doubling time of 1.65±0.09 h at an optimal wavelength of 469.9±0.3 nm. Besides the easy and monolithic integration of the SWG into poly(dimethylsiloxane) microfluidic systems, the results presented here are very promising for the application in any disposable photonic lab‐on‐a‐chip systems used for online analysis or photonic MBRs.