bluuebunny/crossref_metadata_2025_split huggingface dataset:
Multi-layered Microfluidic Drug Screening Platform Enabling Simultaneous Generation of Linear and Logarithmic Concentration Gradients
Authors: Yoon Jung Yun Susan , Park Joonha , Nam Hyeono , Kim Seunggyu , Jeon Jessie S. 
Published: May 2024

AbstractSince many microfluidic devices have limited drug dose order of gradients and incorporate 2D cell culture, we here present a multi-layered platform with linear and logarithmic gradients with 3D-cell culturing chambers. By employing Hagen–Poiseuille flow resistance equation and the parallel electric schematics, we determined the appropriate channel dimensions to achieve the desired target concentrations (100%, 50%, 20%, 10%, 5%, 2%, 1%, 0%). To validate the gradient formation against theoretical values, we introduced a solution containing fluorescein into the microfluidic chip. Moreover, cell culturing chambers were spaced out laterally for every 9 mm, aligning with the dimensions with the standard plate reader, providing enhanced usability. Vertical layout of the chip minimized the lateral dimension required for housing various components while maintaining a favorable height for imaging. By preventing the need to use external tubing to connect concentration gradient generator and cell culturing chamber modules, our platform holds promise in facilitating the integration of microfluidics into drug evaluation processes. To demonstrate use of this flexible platform, we tested two chemotherapy drugs against human bladder cancer cells (T24) embedded in 3D fibrin gel and evaluated their cell viability and proliferation rate. IC50 values were extracted for cells exposed to varying doses of cisplatin, gemcitabine, and gemcitabine with a fixed cisplatin dose, confirming the enhanced apoptosis of the bladder cancer cells and the advantages of combination chemotherapy. This simple multi-layered device may accelerate screening of anti-cancer drugs for a specific cell type by extracting optimal dosage for two drugs.
Reducing construction noise: sound masking effect on soundscape dominated by construction noise
Authors: Wu Z. F. , Zhao X. Q. 
Published: May 2024

AbstractPeople move to cities to enjoy the conveniences of modern life, but the resulting population growth comes with issues such as increased noise. While public awareness of noise pollution is increasing, noise emanating from construction sites remains a source of complaint. Despite the actions taken by different parties to control construction noise, newly constructed structures continue to exacerbate the harmful consequences of noise. The acoustic environment in some areas of cities, such as London, can no longer provide the tranquility expected by residents, and the risk of daily disruptions for those living near construction sites is high. Given the various limitations and complications of current construction noise control methods, the campaign to limit construction noise must embrace other strategies. Sound masking can potentially abate noise without resorting to time-consuming procedures. In this paper, five raw construction noise datasets were collected around an existing noise-sensitive premise. Five masker sound datasets were recorded to form seven mixed sounds to create a comparative experiment on masking construction noise. A case study and additional research are presented to demonstrate the mechanism of sound masking and to investigate the factors involved in effectively masking construction noise using the sound masking concept. Based on the case study and theoretical research findings, suggestions for masker selection of specific noise datasets and conclusions regarding ideal sound simultaneous masking of construction noise are provided.
Bearing Capacity Characteristic Analysis of Anti-floating Bolts in Unsaturated Soil Based on Mindlin Solution
Authors: Fu Xu , LI Qian , Liu Huanqin , Wang Lintai , Liu Xiaoli 
Published: May 2024

AbstractBased on Mindlin solution and the theory of unsaturated soil mechanics, the theoretical solutions of shear stress and axial force distribution in the elastic stage of full-length binding-type anti-floating bolts were derived, and the bearing capacity characteristics of such bolts and the influencing factors were analyzed. In this paper, the design parameters of anti-floating anchor in a negative two-floor basement of a commercial square are substituted into the formula derived in this paper. The results show that, in unsaturated soil, the shear stress and axial force of the full-length bonded anti-floating anchor are distributed along the total length of the anchor, but neutral points appear in both of them, which is mainly due to the reduction of the axial force and shear stress of the anti-floating anchor caused by the matric suction. The formula derived in this paper is used to analyze the factors affecting the bearing capacity of anti-floating anchor bolt in unsaturated soil. The results show that: the greater the elastic modulus of soil mass, the greater the peak value of shear stress curve, the closer the peak value is to the head of anchor bolt, and the greater the axial force decline rate. With the increase of anchor solid diameter D, the peak value of shear stress decreases, the peak value moves backward, the neutral point moves forward, the negative shear stress value increases, the decline rate of axial force distribution curve decreases, but the negative axial force increases. With the increase of the additional shear stress τ0, the peak value of the shear stress curve decreases, the peak value moves to the hole of the anchor rod, the neutral point moves to the hole, the negative shear stress increases, the decline rate of the axial force distribution curve increases, and the negative axial force increases.
Update on Perioperative Antithrombotic Management
Authors: Boschitz Daniel , Fastowiec Dominika M. , Bolliger Daniel 
Published: May 2024

Abstract
Purpose of the Review
In this review, we discuss the recent studies and recommendations on the perioperative management of oral anticoagulant and antiplatelet drugs.

Recent Findings
In elective surgery, clear and simple recommendations exist for oral anticoagulants and antiplatelet drugs. The shorter stopping intervals with direct-acting oral anticoagulants have simplified the perioperative management compared with vitamin K antagonists. The specific use of laboratory testing is suggested for bleeding patients treated with antithrombotic drugs or for emergent surgery. The postoperative prevention of thromboembolism has gained more attention, and individualized strategies including extended treatment or use of aspirin has been suggested in specific patients. The use of risk scores might be helpful for decision making.

Summary
The perioperative management of anticoagulants and antiplatelet drugs is still challenging, especially in urgent or emergent surgery. The use of individualized strategies to prevent perioperative bleeding and thromboembolic events rather than a “one-size-fits-all” approach is suggested.
Water flow in two Cactaceae species: standardization of the method and test under different drought conditions
Authors: Maceda Agustín , Trejo Carlos , Terrazas Teresa 
Published: May 2024

AbstractInvestigating water flow in the vascular system of plants is important to identify the water path and conduction capacity of different plant species, mainly in succulent species living in dry regions. This study aimed to standardize a method to track water flow in the xylem of Mammillaria bocasana and Echinocereus reichenbachii var. fitchii (Cactaceae) and test it under different drought conditions. The plants were kept under greenhouse conditions to perform the split root method, water flow tracing, and different drought treatments. The plants of each species were separated into three treatments: constant irrigation, drought with water and dye, and drought with dye. Plants were cut 24 h after staining, total and lumen diameters were taken, and the relative theoretical hydraulic conductivity was calculated. The absorption method was adequate for the tracing of water flow, and it worked in all the treatments of the drought experiment. Conducting elements, including wide-band tracheids, were stained violet and were located near the vascular cambium. In Mammillaria bocasana, half of the vascular cylinder was stained, while in Echinocereus reichenbachii var. fitchii, the entire cylinder was stained due to the cortical bundles. M. bocasana had a higher lumen diameter and relative theoretical hydraulic conductivity than E. reichenbachii var. fitchii. With the absorption staining method, the flow of water was traced, and differences in conduction under water stress conditions between the two species of cacti were detected. These results suggest that cacti species living under water stress solve the water movement in different ways.
Effect of crack density on crack initiation and damage for high confining pressure using wave velocities
Authors: Zhang Min , Zhang Guangqing , Sun Wei , Chen Lei , Zheng Xuelin , Xu Changzhuo 
Published: May 2024

AbstractThe study of progressive failure of reservoir rocks is very important for the stability analysis of ultra-deep boreholes. The progressive failure can be characterized by the crack initiation stress (CI), crack damage stress (CD) and peak stress (Peak), which is controlled by the evolution of cracks in rock and is significantly affected by confining pressure. To explore the effect of high confining pressure and initial crack on the progressive failure, the initial crack density of 121 sedimentary rock samples was characterized by acoustic waves, and the progressive failure under different confining pressures was analyzed. Experiments show that the ratios of CI to Peak (CI/Peak) and CD to Peak (CD/Peak) increase significantly with confining pressure, which is agreement with the existing conclusion from low confining pressure (0–52 MPa), but those decrease for high confining pressure (68–85 MPa) above critical point of sandstone. The CI/Peak and CD/Peak decrease with increase of initial crack density, which is sensitive to confining pressure but independent of rock type and grain size. The CD of sandstone is pertinent to the friction coefficient of cracks. These results laid a foundation for analyzing the evolution mechanism of wellbore damage and predicting the timing of wellbore instability in ultra-deep wells.
Influence of ultraviolet A1 exposures on mood states: a randomized controlled study
Authors: Haapasalo Annina , Pasternack Rafael , Kautiainen Hannu , Ylianttila Lasse , Snellman Erna , Partonen Timo 
Published: May 2024

AbstractWe investigated the effects of daily ultraviolet A1 (UV-A1, 340–400 nm) exposures on mood states (#R19055, approval on 21 October 2020). Based on our earlier findings of the influence of diurnal preference on mood, we investigated further whether diurnal preference plays a role in the influence of UV-A1 on mood states. Forty-one healthy participants aged 19–55 years were randomized to receive either UV-A1 (n = 21) or control (n = 20) exposures (violet light, 390–440 nm). The irradiations were administered on three consecutive mornings on the skin of the buttocks and middle back. Diurnal preference was assessed with the modified 6-item Morningness-Eveningness Questionnaire (mMEQ). Changes in mood were assessed with Total Mood Disturbance (TMD) score of the 40-item Profile of Mood States (POMS) before the first irradiation, immediately after each irradiation and one week after the last irradiation. Mood improved among those subjected to UV-A1 exposures compared with the controls (p = 0.031). Individuals with more pronounced morningness had mood improvement (p = 0.011), whereas those with more pronounced eveningness did not (p = 0.41). At follow-up of one week after the last irradiation the mood improvement had disappeared.
Assessing the carrying capacity of solar dryers applied for agricultural products: a systematic review
Authors: Kidane Halefom , Farkas Istvan , Buzás Janos 
Published: May 2024

AbstractMost of the review research papers previously published were mostly focused on solar dryer design, development, performance evaluation, modification, technologies of solar dryers, etc. There were no works of literature reviews that specifically concerned how much solar dryers can carry. So, the review gives some clues about the carrying capacity of solar dryers. Measuring or knowing solar capacity has critical importance in the drying industry. It helps to produce quality dried products, design efficient solar dryers, and provide valuable insights for researchers, engineers and policymakers involved in solar drying technologies. The current review systematically examines the relevant scientific literature published between 2000 and 2023. The exclusion and inclusion criteria were used to identify the documents. A total of 1230 studies were selected for analysis, encompassing a wide range of geographical regions, crop types, and solar drying technologies. Based on the review conducted; solar dryers (direct, indirect, mixed, and hybrid) can vary between 1 and 250 kg in capacity applied for agricultural products drying purposes. According to the reviewed articles, the minimum loading capacities designed and recorded in the first, second, third, and fourth quinquennial periods were 1 kg, 1 kg, 4.75 kg.m−2, and 5.4 kg.m−2, respectively. In the same order as the minimum, the maximum loading capacities observed in the stated quinquennial periods were 250 kg/per day, 250 kg, 70 kg, and 45 kg, respectively.
Stratifying Mortality Risk in Intensive Care: A Comprehensive Analysis Using Cluster Analysis and Classification and Regression Tree Algorithms
Authors: Romanelli Antonio , Palmese Salvatore , De Vita Serena , Calicchio Alessandro , Gammaldi Renato 
Published: May 2024

Abstract
Background
Machine learning (ML) can be promising for stratifying patients into homogeneous groups and assessing mortality based on score combination. Using ML, we compared mortality prediction performance for clustered and non-clustered models and tried to develop a simple decision algorithm to predict the patient’s cluster membership with classification and regression trees (CART).

Methods
Retrospective study involving patients requiring ICU admission (1st January 2011–16th September 2022). Clusters were identified by combining Charlson Comorbidity Index (CCI) plus Simplified Acute Physiology Score II (SAPS II) or Sequential Organ Failure Assessment (SOFA). Intercluster and survival analyses were performed. We analyzed the relationship with mortality with multivariate logistic regressions and receiver operating characteristic curves (ROC) for models with and without clusters. Nested models were compared with Likelihood Ratio Tests (LRT). Akaike Information Criterion (AIC) and Bayesian Information Criterion (BIC) were compared for non-nested models. With the best model, we used CART to build a decision tree for patient’s membership.

Results
Our sample consisted of 2605 patients (mortality 59.7%). For both score combinations, we identified two clusters (A and B for CCI + SAPS II, α and β for CCI + SOFA). Belonging to cluster B/β was associated with shorter survival times (Peto-Peto p-values < 0.0001) and increased mortality (Odds-ratio 4.65 and 5.44, respectively). According to LRT and ROC analysis, clustered models performed better, and CCI + SOFA showed the lowest AIC and BIC values (AIC = 3021.21, BIC = 3132.65). Using CART (β cluster positive case) the accuracy of the decision tree was 94.8%.

Conclusion
Clustered models significantly improved mortality prediction. The CCI + SOFA clustered model showed the best balance between complexity and data fit and should be preferred. Developing a user-friendly decision-making algorithm for cluster membership with CART showed high accuracy. Further validation studies are needed to confirm these findings.
A Joban Theology of Consolation
Authors: Yadav Sameer 
Published: May 2024

AbstractContrary to much of the commentary tradition, the book of Job is not primarily a discourse on how to properly speak (or withhold speech) about God in the midst of innocent suffering, nor is it aimed primarily at offering up the character of Job as an exemplar of how to suffer correctly (or incorrectly). Neither is it a treatise about human submission to (or rebellion from) God’s mysterious sovereign prerogative in permitting evil. It is instead a theological exploration of the dilemmas and demands of consolation that confront us given the inexplicable enormities of human suffering. Its unifying aim is to confront us with multiple voices that pull us into an open-ended—and decidedly pessimistic—reflection on what innocent suffering reveals to us about our creaturely limits and the fragility of our hope in God, features of the human condition that require our capacities for compassion to exceed our capacities for theological sense-making.
Judeopessimism: Antisemitism, History, and Critical Race Theory
Authors: Magid Shaul 
Published: May 2024

AbstractThis essay coins a term “Judeopessimism,” engaging questions of some of the contemporary writing on antisemitism and its claim to be historical in nature through the lens of critical race theory, specifically Afropessimism and its offshoots, which make claims of anti-Blackness as political ontology. Is some of this writing on antisemitism really making theological or political ontological claims of “eternal antisemitism” refracted in a less volatile historical narrative? How can critical race theory and its understanding of anti-Blackness help refine, clarify, and push the discussion on antisemitism to be more forthright about its underlying claims? I explore some examples of ontological antisemitism in the writings of Meir Kahane and Naftali Zvi Berlin who each in different ways offer ahistorical and even ontological views on antisemitism that are mostly shunned by contemporary writing on the subject and suggest that Afropessimism offers a helpful way to see beyond the historical veil of how antisemitism is understood today.
Fighting against assisted dying in Spain: catholic-inspired civic mobilization during the COVID-19 pandemic
Authors: García Martín Joseba , Perugorría Ignacia 
Published: May 2024

AbstractThe article analyzes the network structure and dynamics of the Spanish field of catholic-inspired secular organizations (CISO-N), and their mobilization against the Euthanasia Bill amidst the COVID-19 pandemic. In addition to a relational perspective, it adopts a historical-comparative approach to political opportunities that affect the praxis of these organizations. Drawing on 7-year fieldwork, including in-depth interviews with CISO-N activists and participant observation of their demonstrations, it traces CISO-N's discourse of ‘moral panic’ and ties to religious and political organizations, particularly the far-right party VOX. We advance a novel perspective, bridging literature on assisted dying and social movement studies, particularly focusing on far-right Christian populist mobilizations. The article offers one of the first sociological analyses of euthanasia as the new moral, political, and cultural neoconservative anti-rights front, which has been mainly studied from bioethics, socio-medical studies, and medical jurisprudence perspectives.
The Population-Based Hungarian Twin Registry: An Update
Authors: Tarnoki David Laszlo , Piroska Marton , Forgo Bianka , Szabo Helga , Zoldi Luca , Melicher Dora , Metneki Julia , Littvay Levente , Tarnoki Adam Domonkos 
Published: May 2024

AbstractBetween 2006 and 2021, the Hungarian Twin Registry (HTR) operated a volunteer twin registry of all age groups (50% monozygotic [MZ], 50% dizygotic [DZ], 70% female, average age 34 ± 22 years), including 1044 twin pairs, 24 triplets and one quadruplet set. In 2021, the HTR transformed from a volunteer registry into a population-based one, and it was established in the Medical Imaging Centre of Semmelweis University in Budapest. Semmelweis University’s innovation fund supported the development of information technology, a phone bank and voicemail infrastructure, administrative materials, and a new website was established where twins and their relatives (parent, foster parent or caregiver) can register. The HTR’s biobank was also established: 157,751 individuals with a likely twin-sibling living in Hungary (77,042 twins, 1194 triplets, 20 quadruplets, and one quintuplet) were contacted between February and March of 2021 via sealed letters. Until November 20, 2022, 12,001 twin individuals and their parents or guardians (6724 adult twins, 3009 parents/guardians and 5277 minor twins) registered, mostly online. Based on simple self-reports, 37.6% of the registered adults were MZ twins and 56.8% were DZ; 1.12% were triplets and 4.5% were unidentified. Of the registered children, 22.3% were MZ, 72.7% were DZ, 1.93% were triplets, and 3.05% were unidentified. Of the registered twins, 59.9% were female (including both the adult and minor twins). The registration questionnaire consists of eight parts, including socio-demographic and anthropometric data, smoking habits and medical questions (diseases, operations, therapies). Hungary’s twin registry has become the sole and largest population-based twin registry in Central Eastern Europe. This new resource will facilitate performing world-class modern genetic research.
Frictional Stability of Laumontite Under Hydrothermal Conditions and Implications for Injection‐Induced Seismicity in the Gonghe Geothermal Reservoir, Northwest China
Authors: Zhang Chongyuan , Hu Zijuan , Elsworth Derek , Zhang Lei , Zhang Hao , Zhang Linyou , He Manchao , Yao Leihua 
Published: May 2024

AbstractLaumontite is a common and potentially frictionally unstable hydrothermal alteration product present in deep faults of the Gonghe EGS reservoir. We characterize the friction‐stability characteristics of synthetic laumontite gouge under in situ reservoir conditions. The pure laumontite gouge is frictionally strong (μ = 0.73–0.98) and the quartz/laumontite mixture (1:1) is generally less strong (μ = 0.73–0.78) under experimental conditions (Pc = 95 MPa, T = 90–250°C, Pf = 0–90 MPa). The shear velocity was stepped between 6.1, 0.61, then 0.061 μm/s for our experiments. For both gouges, the friction coefficient is independent of temperature and increases with elevated pore pressures. The pure gouge and mixture are strongly velocity‐weakening over a broad range in temperatures (∼90–220°C) and excess pore pressures (0–90 MPa) relevant to the Gonghe stimulation. Microearthquakes (MEQs) observed during stimulation are confined to within the broad depth range of inferred frictional instability—although fluid overpressures are also limited to this region. The observation that laumontite mixtures are frictionally unstable over a broad range of pressures and especially temperatures representative of EGS reservoirs and insensitive to the presence of the coexisting mineral phase (quartz) suggests its presence is a strong indicator of potential seismic hazard.