bluuebunny/crossref_metadata_2025_split huggingface dataset:
HUBUNGAN PENGETAHUAN DAN SIKAP DENGAN KEPATUHAN MINUM OBAT PENDERITA TUBERCULOSIS (TBC) DI WILAYAH KERJA PUSKESMAS KUPA-KUPA KECAMATAN TOBELO SELATAN
Authors: Egandini Maga Gabriella , Hohedu Ribka Yulianti 
Published: May 2024

Penelitian ini bertujuan untuk mengetahui hubungan pengetahuan dan sikap dengan kepatuhan minum obat penderita Tuberculosis (TBC) di Wilayah Kerja Puskesmas Kupa-Kupa Kecamatan Tobelo Selatan. Metode dalam penelitian ini menggunakan metode kuantitatif dengan pendekatan cross sectional. Teknik pengambilan sampel menggunakan Teknik Sampling dengan jumlah sampel sebanyak 55 responden dengan menggunakan uji spearman rho dengan kesalahan 5% (p<0,005) diperoleh p vlue 0,000 yang berarti p<0,005. Hasil penelitian menunjukan tidak ada hubungan pengetahuan dengan kepatuhan minum obat penderita Tuberculosis, tetapi ada hubungan sikap dengan kepatuhan minum obat penderita Tuberculosis (TBC) sehingga diharapkan bagi penderita Tuberculosis (TBC) agar lebih meningkatkan pengetahuan agar dapat mengoptimalkan dalam mengonsumsi obat. Bagi pelayanan kesehatan lebih banyak berperan aktif dalam memberikan edukasi yang baik kepada penderita Tuberculosis (TBC) bagi peneliti selanjutnya diharapkan dapat mengembangkan penelitian lebih luas lagi dalam meneliti hubungan pengetahuan dan sikap dengan kepatuhan minum obat penderita Tuberculosis, melakukan penelitian dengan variabel yang lebih banyak lagi.
Implementasi Pembiayaan Retail Banking pada Bank Muamalat Indonesia di Tengah Pandemi Coronavirus Disease 19
Authors: Istiqomawati Rina , Quraisy Mujahd , Hasibuan Badar Ali Jalil 
Published: May 2024

Perekonomian di Indonesia saat ini sedang mengalami perlambatan perputaran ekonomi yang disebabkan oleh suatu wabah virus covid 19 atau yang dikenal dengan Coronavirus Disease 19. Wabah ini memaksa individu, kelompok, institusi dan negara, untuk mengubah pola hidup dan perilakunya selama ini. Akibat virus ini terjadinya penurunan pembiayaan di berbagai bank, tanpa terkecuali Bank Muamalat Indonesia. Pembiayaan sampai saat merupakan pendapatan terbesar di suatu Bank Syariah, maka dari itu peneliti sangat tertarik untuk mengangkat judul ini sebagai penelitian. Jenis penelitian ini adalah penelitian lapangan (field research) dengan mengambil lokasi penelitian di Bank Muamalat Indonesia Kantor Cabang Utama Yogyakarta, dengan pendekatan kualitatif. Responden dalam penelitian berupa Branch Development Financing Manager dan Relationship Manager SME, sedangkan variabel dalam penelitian Implementasi Pembiayaan Retail Banking di Tengah Pandemi Coronavirus Disease 19 (Covid 19). Data berupa data primer, data primer diperoleh dari wawancara. Teknik analisis menggunakan metode interaktif dari Miles dan Huberman. Hasil penelitian ini menunjukkan bahwa, Bank Muamalat Indonesia Cabang Utama Yogyakarta memberikan berbagai kebijakan yaitu : terdapatnya pengalihan target yang diberikan kepada marketing, terdapatnya pembiayaan alternatif yaitu back to back, diberikannya kemudahan bagi nasabah yang ingin mengajukan pembiayaan dan pengakadan, serta diberikannya kemudahan bagi nasabah terdampak untuk dapat mengajukan keringanan angsuran dengan cara restrukturisasi sesuai surat edaran OJK (Otoritas Jasa Keuangan) Nomor 11/POJK.03/2020.
Hubungan Pemahaman tentang Hak Cipta dengan Pelanggaran Tindak Pengunduhan Film Gratis di Situs Internet
Authors: Apriliant Assa Oviana , Suhadi Suhadi , Kardiman Yuyus 
Published: May 2024

Penelitian ini bertujuan untuk mengetahui ada atau tidaknya hubungan pemahaman tentang hak cipta dengan pelanggaran tindak pengunduhan film gratis di situs internet. Menggunakan pendekatan kuantitatif dan metode korelasi product moment, yaitu penelitian yang dilakukan untuk mengetahui apakah terdapat hubungan variabel x dan variabel y. Pengambilan sampel menggunakan teknik purposive sampling yaitu penentuan sampel dengan pertimbangan tertentu, dengan jumlah sampel terdiri dari 80 responden. Teknik uji coba menggunakan rumus Cronbach’s Alpha, sedangkan teknik uji prasyarat analisis dan uji hipotesis menggunakan software SPSS versi 22. Hasil penelitian berdasarkan data dan analisis yang telah dilakukan menunjukkan nilai rhitung 0,541 yaitu berkorelasi sedang, dan terdapat hubungan positif antara pemahaman hak cipta dengan pelanggaran pengunduhan film. Berdasarkan uji koefisien determinasi jika dilihat dari pemahaman hak cipta (variabel x) memberikan kontribusi pengaruh yang cukup berarti yaitu sebanyak 29,2% dalam menentukan pelanggaran pengunduhan film (variabel y). Mahasiswa diharapkan mengetahui tindakan yang salah atau benar dalam mengapresiasi suatu karya.
Efektivitas Solusi pada Kasus Top Up Game Online dalam Meminimalisir Resiko
Authors: Warsito Eko 
Published: May 2024

Penelitian ini bertujuan untuk mengkaji kesuaian antara kasus top up game dengan sudut pandang Larry Laudan. Penelitian ini menggunakan metode penelitian kualitatif dengan pendekatan studi kasus. Hasil penelitian menemukan bahwa kasus tersebut sebagai pembuktian idealis terhadap pemikiran Larry Laudan pada ketidaksinambungan realitas dengan ilmu pengetahuan. Pemikiran Laudan memberikan pada pemecahan masalah dengan memaksimalkan apa yang belum dianggap sebagai kebenaran yang kompleks melalui sebuah ilmu pengetahuan, bentuk rasa ilmu pengetahuan tidak hanya tercermin melalui pengaplikasian teori, melainkan kepada penerapan kepada setiap tindakan sebagai sebuah solusi. Tindakan yang dilakukan oleh orang tua yang menyerang pada salah satu perspektif yang dianggap benar. Pemikiran Laudan bukan menentukan apa yang menjadi persoalan benar atau salah, melainkan bagaimana seharusnya sebuah ilmu pengetahuan atau sains menaruh pada pemecahan masalah dalam permasalahan. Pemikiran Larry Laudan memberikan benang merah terhadap keefektivitasan sebuah pencarian solusi dalam meminimalisir resiko, dengan mengikuti sains atau ilmu pengetahuan sebagai bentuk dari bukti-bukti yang empiris dan data yang faktual.
Preclinical Validation of FTY720 and FTY720-Mitoxy in Mouse Models of Parkinsons Disease and Multiple System Atrophy (MSA): Evidence for Treating Lewy Body Disease Synucleinopathies Including MSA
Authors: Vidal-Martinez Guadalupe , Lou Haiyan , G. Perez Ruth 
Published: May 2024

We assessed FTY720 and our patented-mitochondria-localizing-FTY720-derivative, FTY720-Mitoxy, in mouse models of Parkinson’s disease (PD) and MSA. FTY720 and FTY720-Mitoxy were given by gavage, injection, or osmotic pump. We used symptomatic transgenic alpha-Synuclein (aSyn) PD mice (A53T aSyn) and MSA mice (CNP-aSyn), as well as transgenic GM2 +/− PD mice. We also tested toxin PD and MSA models. We measured movement, constipation, gut motility, sweat ability, and bladder function. We counted blood lymphocytes 24 h after FTY720 or FTY720-Mitoxy. We measured Brain Derived Neurotrophic Factor (BDNF), Glial Cell Line Derived Neurotrophic Factor (GDNF), and Nerve Growth Factor (NGF) mRNA and protein. We assessed aSyn insolubility in gut, brain, and spinal cord by sequential protein extraction and immunoblot. We assessed fecal genomic DNA using 16S rRNA sequencing. In PD mice FTY720 normalized body and gut movement, urinary bladder function while increasing trophic factors and eliminating synucleinopathy. In MSA mice FTY720-Mitoxy normalized body and gut movement, sweat ability, mitochondrial function, improved microbiota while increasing trophic factors and eliminating synucleinopathy. FTY720 and FTY720-Mitoxy improve function and counteract synucleinopathy. As FTY720-Mitoxy is not immunosuppressive, it may be safer for treating PD and/or MSA.
Perancangan Ulang Tampilan Aplikasi Perpustakaan Digital ISOLOKKAB Berbasis Design Thinking
Authors: Irrisandi Nadya Putri , Erlianti Gustina 
Published: May 2024

Redesigning the appearance of the application is the process of redesigning the existing design with the aim of improving the user experience. This is due to the appearance of the application that is still behind compared to other applications. The purpose of this redesign is to produce an improved display that has been redesigned as a recommendation for the development of the iSolokKab digital library application. This redesign was carried out using interview techniques to iSolokKab application users and reviews from users from the Play Store. iSolokKab needs improvement both from the appearance design and features. The method used in this redesign process is the design thinking method. Design thinking is a method that focuses on user complaints and provides suitable solutions to problems experienced by users in the application. Therefore, this method is very suitable for the process of redesigning the appearance of this iSolokKab application, because it can understand user needs. Based on the results of tests that have been carried out on improving the appearance design of the iSolokKab application, it can be said that it is easy to understand by users, judging from the tests conducted on 5 respondents with an average time spent on each task of 9.6 seconds and no click errors. As a result, the process of redesigning this display design is fairly well understood by users because users can complete tasks easily. The redesign of the appearance of the iSolokKab application is expected to be a reference and improve the quality of the performance of the iSolokKab application itself.
La fragilidad en la unidad de cuidados cardiacos agudos: Estudio de prevalencia e impacto pronóstico
Authors: Siverio Lorenzo Emilio , García González Martín Jesús , Jiménez Sosa Alejandro , Pérez Martín Pedro , Martín Lechado Marta , Jorge Donate Alicia , Illada Rodríguez Verónica María , Regalado Arocha Myriam , Gorrín De La Rosa María Candelaria , García Escribano María Begoña 
Published: May 2024

Introducción. El objetivo de este estudio fue valorar la prevalencia e impacto pronóstico que ejerce la presencia de fragilidad en pacientes ancianos ingresados en la unidad de cuidados cardiacos agudos.
Material y método. Estudio de pacientes mayores de 65 años que ingresaron de forma consecutiva en la unidad de cuidados cardiacos agudos durante 3 meses. Se recogieron datos demográficos, analíticos, test y escalas de medidas geriátricas y cardiológicas, evolutivos y complicaciones durante el ingreso.
Resultados. Se incluyó a 105 pacientes, edad media: 77,8 años, 66 % varones. Los diagnósticos de ingreso más frecuentes fueron: síndrome coronario agudo (29,5 %), bloqueo auriculoventricular (24,8 %), insuficiencia cardiaca aguda (15,25 %) y postintervencionismo (14,3 %). La prevalencia de pacientes frágiles fue del 22,9 %. Se encontró asociación entre fragilidad y aspectos generales (mayor edad, sexo femenino, peor clase funcional, menor nivel de hemoglobina al ingreso y de filtrado glomerular al ingreso, menor nivel de triglicéridos, mayor estancia hospitalaria, y peor calidad de vida), valoración geriátrica (dependencia, deterioro cognitivo, depresión y polifarmacia), la nutrición (peor estado nutricional, menor índice de masa corporal, niveles bajos de albúmina, calcio y sideremia) y con complicaciones evolutivas (insuficiencia cardiaca, flebitis, fracaso renal agudo y mayor riesgo de mortalidad intrahospitalaria).
Conclusiones. La fragilidad es un síndrome altamente prevalente en pacientes de la unidad de cuidados cardiacos agudos. Su detección, como parte de la valoración de enfermería en este tipo de unidades, es esencial, puesto que se asocia a un impacto negativo en el proceso asistencial de los pacientes.

Palabras clave: fragilidad, envejecimiento, enfermería intensiva, cuidados cardiacos agudos, prevalencia, pronóstico.
Influencia de la Revolución Francesa en los Derechos Humanos y el Derecho Administrativo
Authors: Araúz Sánchez Heriberto 
Published: May 2024

La Revolución Francesa, fue el comienzo de muchos cambios en la sociedad y el comienzo de postulados encaminados a los Derechos Humanos plasmados en Tratados Internacionales hoy día, en especial, la Declaración de los derechos del hombre y el ciudadano como la Convención Americana de Derechos Humanos, con el propósito de una mejor convivencia social a nivel mundial, después del desastre de la primera y segunda guerra mundial.
La Revolución Francesa introdujo la división de poderes en la administración del Estado, consensuado en el período de La Ilustración e influenciado por filósofos como consecuencia de un movimiento social contra la monarquía establecida, comenzando una época de nuevas Constituciones influenciadas por la Constitución Francesa y la Constitución de los Estados Unidos de América, pioneras de establecer parámetros fundamentales sociales de derechos humanos y a la vez reguladoras del abuso de poder a través de leyes controladoras del aparato estatal, lo que hoy conocemos como el Derecho Administrativo.
Hubungan antara Komitmen Organisasi dengan Kinerja Guru SD Metta Maitreya Pekanbaru
Authors: Sutikno Yadi , Hosan Hosan , Irawati Irawati 
Published: May 2024

This research is motivated by the performance of the teachers at SD Metta Maitreya which are still not professional, there are still scores of students under the KKM, and a lack of organizational commitment to school teachers, and there are still teachers who lack teacher responsibility at work. Therefore, this study aims to determine the relationship between organizational commitment and organizational culture with the performance of teachers at SD Metta Maitreya Pekanbaru. The research method used is a survey method with correlational techniques. The study population was 24 teachers of SD Metta Maitreya Pekanbaru, so the sample was 24 people. The data collection instrument was in the form of a questionnaire or questionnaire. The validity and reliability of the questionnaire on performance, organizational commitment, and organizational culture have been tested. The data normality test was carried out by the Kolmogorov Smirnov test. The data analysis used was multiple correlation analysis using a level of α = 0.05. The results of data analysis show that there is a significant relationship between Organizational Commitment (X1) and Organizational Culture (X2) and Teacher Performance (Y) together with the regression equation Y = 81.388 + 0.295X1 + 0.466X2, the correlation coefficient is 0.570. The results of this study are expected to be useful for improving the performance, organizational commitment and organizational culture of SD Metta Maitreya Pekanbaru. The conclusion of this study shows that performance can be increased through increasing organizational commitment and organizational culture simultaneously.
Health impact of electric discharge weapons: a review of case studies
Authors: Brasholt Marie , Aon Maha , Michaelsen Lisa , Modvig Jens 
Published: May 2024

Introduction
Electrical discharge weapons (EDWs) are increasingly used by law enforcement around the globe as a less lethal option to firearms. Concerns have been raised about their use, inter alia from the UN Committee Against Torture (UNCAT).
The purpose of this manuscript is to provide an overview of case studies to assess the health consequences of EDW exposure.
Methods
Medline and Pubmed were searched for case studies on EDWs without restriction on language or date. Screening was first at abstract level and then at full article level. Articles were excluded if they were not case studies, concerned children under 15 years old or were off topic. A PRISMA flow diagram was created.
Results
A total of 71 studies were included, and they demonstrate a wide range of health consequences from minor injuries to lethal conditions. The injuries can be classified as direct and indirect, i.e., related to the use itself (e.g., penetration by darts) and related to falls and burns following neuromuscular incapacitation and ignition of flammable fluids. Cardiac incidents – some being fatal - were the health consequences found most reported, but the relation to the EDW is contested. In other cases, a very plausible association is established between EDW exposure and the health consequences. Description of pain and mental suffering related to EDW exposure was lacking in the reviewed case studies.
Discussion
EDWs may lead to physical and most likely mental suffering. When assessing patients and when documenting cases where persons may have been exposed to EDWs, including torture and ill-treatment cases, it is important to be aware of the different types of health consequences.
Enhancing early breast cancer diagnosis through automated microcalcification detection using an optimized ensemble deep learning framework
Authors: Teoh Jing Ru , Hasikin Khairunnisa , Lai Khin Wee , Wu Xiang , Li Chong 
Published: May 2024

Background
Breast cancer remains a pressing global health concern, necessitating accurate diagnostics for effective interventions. Deep learning models (AlexNet, ResNet-50, VGG16, GoogLeNet) show remarkable microcalcification identification (>90%). However, distinct architectures and methodologies pose challenges. We propose an ensemble model, merging unique perspectives, enhancing precision, and understanding critical factors for breast cancer intervention. Evaluation favors GoogleNet and ResNet-50, driving their selection for combined functionalities, ensuring improved precision, and dependability in microcalcification detection in clinical settings.

Methods
This study presents a comprehensive mammogram preprocessing framework using an optimized deep learning ensemble approach. The proposed framework begins with artifact removal using Otsu Segmentation and morphological operation. Subsequent steps include image resizing, adaptive median filtering, and deep convolutional neural network (D-CNN) development via transfer learning with ResNet-50 model. Hyperparameters are optimized, and ensemble optimization (AlexNet, GoogLeNet, VGG16, ResNet-50) are constructed to identify the localized area of microcalcification. Rigorous evaluation protocol validates the efficacy of individual models, culminating in the ensemble model demonstrating superior predictive accuracy.

Results
Based on our analysis, the proposed ensemble model exhibited exceptional performance in the classification of microcalcifications. This was evidenced by the model’s average confidence score, which indicated a high degree of dependability and certainty in differentiating these critical characteristics. The proposed model demonstrated a noteworthy average confidence level of 0.9305 in the classification of microcalcification, outperforming alternative models and providing substantial insights into the dependability of the model. The average confidence of the ensemble model in classifying normal cases was 0.8859, which strengthened the model’s consistent and dependable predictions. In addition, the ensemble models attained remarkably high performances in terms of accuracy, precision, recall, F1-score, and area under the curve (AUC).

Conclusion
The proposed model’s thorough dataset integration and focus on average confidence ratings within classes improve clinical diagnosis accuracy and effectiveness for breast cancer. This study introduces a novel methodology that takes advantage of an ensemble model and rigorous evaluation standards to substantially improve the accuracy and dependability of breast cancer diagnostics, specifically in the detection of microcalcifications.
Effect of Different Treatments on Chemical Components of Fermented Probiotic Millet Dried Mix
Authors: Jayashree H  , Devaraju R  , Raju Naik B  , Malashree L  , Shilpashree B  , Ramachandra B  
Published: May 2024

Aims: The purpose of this study was to develop fermented probiotic millet dried mix by incorporating a probiotic Lactobacillus acidophilus and to ascertain how different processes used in the product's development affected its chemical components.
Study Design: Fermented probiotic millet dried mix was developed by fermentation of germinated finger millet flour and Reconstituted Skim Milk (RSM) with L. acidophilus. The impact of various treatments on moisture, crude protein, crude fiber, total ash, alcoholic acidity and phytate content were investigated.
Place and Duration of Study: Department of Dairy Microbiology, Dairy Science College, Hebbal, Bengaluru, Karnataka, India between June 2023 and April 2024.
Methodology: Moisture, crude protein, crude fiber, total ash, alcoholic acidity and phytate content were examined after various treatments such as soaking, germination, autoclaving, fermentation and drying of millet dried mix.
Results: At 10% L. acidophilus inoculum level and a 1:1.5 millet to RSM ratio, a maximum viability of 9.52 log10 cfu/g was reported after 30 h of fermentation. After freeze drying of fermented probiotic millet mix with 2% Skim Milk Powder (SMP) as a cryoprotective agent, viability was retained to 9.50 log10 cfu/g. The optimized fermented probiotic millet dried mix had 4.76% moisture, 11.94% crude protein, 6.50% crude fiber, 4.74% total ash, 1.90% alcoholic acidity and 1.73 mol/kg of phytate.
Conclusion: The resultant fermented probiotic millet dried mix was rich in nutrients and the probiotic L. acidophilus helps to improve gut health. Thus, the product had combined therapeutic and nutritional benefits of probiotics with millet.
Safety evaluation of sinus surfactant solution on respiratory cilia function
Authors: Chiu Alexander G. , Chen Bei , Palmer James N. , O'Malley Bert W. , Cohen Noam A. 
Published: June 2011

AbstractBackground:A common complaint of chronic rhinosinusitis (CRS) is thickened inspissated nasal secretions and concomitant postnasal drip. Recently, the use of diluted, baby shampoo demonstrated modest improvement in these complaints. Removal of hair‐specific ingredients, such as thickeners and fragrances, and addition of a humectant and optimization of mucoactive ingredients generated a topical surfactant solution designed for sinonasal use. This study evaluates the safety of this solution on respiratory cilia function.Methods:Murine nasal explants as well as murine nasal air‐liquid interface cultures were tested. Using high‐speed video microscopy, baseline ciliary beat frequency (CBF) was established, followed by addition of the surfactant solution. CBF was recorded every 30 seconds for 15 minutes.Results:Sinonasal surfactant solution diluted in bicarbonate buffered saline resulted in a transient increase of CBF in murine explants and mature epithelial cultures with no evidence of toxicity on respiratory cilia over the 15 minutes.Conclusion:Respiratory mucosal explants and air‐liquid interface cultures demonstrate robust ciliary beating and represent 2 model systems for screening topical agents for ciliotoxicity. In both systems, application of a novel sinonasal surfactant solution diluted in bicarbonate buffered saline was not ciliotoxic to respiratory epithelium over a 15‐minute period. © 2011 ARS‐AAOA, LLC.