bluuebunny/crossref_metadata_2025_split huggingface dataset:
Quality of ChatGPT Responses to Frequently Asked Questions in Carpal Tunnel Release Surgery
Authors: Amen Troy B. , Torabian Kaveh A. , Subramanian Tejas , Yang Brian W. , Liimakka Adriana , Fufa Duretti 
Published: May 2024

Background:
Although demonstrating remarkable promise in other fields, the impact of artificial intelligence (including ChatGPT in hand surgery and medical practice) remains largely undetermined. In this study, we asked ChatGPT frequently asked patient-focused questions surgeons may receive in clinic from patients who have carpel tunnel syndrome (CTS) and evaluated the quality of its output.

Methods:
Using ChatGPT, we asked 10 frequently asked questions that hand surgeons may receive in the clinic before carpel tunnel release (CTR) surgery. Included questions were generated from the authors’ own experiences regarding conservative and operative treatment of CTS.

Results:
Responses from the following 10 questions were included: (1) What is CTS and what are its signs and symptoms? (2) What are the nonsurgical options for CTS? (3) Should I get surgery for CTS? (4) What is a CTR and how is it preformed? (5) What are the differences between open and endoscopic CTR? (6) What are the risks associated with CTR and how frequently do they occur? (7) Does CTR cure CTS? (8) How much improvement in my symptoms can I expect after CTR? (9) How long is the recovery after CTR? (10) Can CTS recur after surgery?

Conclusions:
Overall, the chatbot provided accurate and comprehensive information in response to most common and nuanced questions regarding CTS and CTR surgery, all in a way that would be easily understood by many patients. Importantly, the chatbot did not provide patient-specific advice and consistently advocated for consultation with a healthcare provider.
Mitochondrial antiviral signaling protein enhances MASLD progression through the ERK/TNFα/NFκβ pathway
Authors: Nóvoa Eva , da Silva Lima Natália , Gonzalez-Rellan Maria J. , Chantada-Vazquez Maria D.P. , Verheij Joanne , Rodriguez Amaia , Esquinas-Roman Eva M. , Fondevila Marcos F. , Koning Mirja , Fernandez Uxia , Cabaleiro Alba , Parracho Tamara , Iglesias-Moure Jose , Seoane Samuel , Porteiro Begoña , Escudero Adriana , Senra Ana , Perez-Fernandez Roman , López Miguel , Fidalgo Miguel , Guallar Diana , Martinez-Chantar Maria L. , Dieguez Carlos , Varela-Rey Marta , Prevot Vincent , Schwaninger Markus , Meijnikman Abraham , Bravo Susana B. , Frühbeck Gema , Nogueiras Ruben 
Published: May 2024

Background and Aims:
Mitochondrial antiviral signaling protein (MAVS) is a critical regulator that activates the host’s innate immunity against RNA viruses, and its signaling pathway has been linked to the secretion of proinflammatory cytokines. However, the actions of MAVS on inflammatory pathways during the development of metabolic dysfunction–associated steatotic liver disease (MASLD) have been little studied.

Approach and Results:
Liver proteomic analysis of mice with genetically manipulated hepatic p63, a transcription factor that induces liver steatosis, revealed MAVS as a target downstream of p63. MAVS was thus further evaluated in liver samples from patients and in animal models with MASLD. Genetic inhibition of MAVS was performed in hepatocyte cell lines, primary hepatocytes, spheroids, and mice. MAVS expression is induced in the liver of both animal models and people with MASLD as compared with those without liver disease. Using genetic knockdown of MAVS in adult mice ameliorates diet-induced MASLD. In vitro, silencing MAVS blunts oleic and palmitic acid–induced lipid content, while its overexpression increases the lipid load in hepatocytes. Inhibiting hepatic MAVS reduces circulating levels of the proinflammatory cytokine TNFα and the hepatic expression of both TNFα and NFκβ. Moreover, the inhibition of ERK abolished the activation of TNFα induced by MAVS. The posttranslational modification O-GlcNAcylation of MAVS is required to activate inflammation and to promote the high lipid content in hepatocytes.

Conclusions:
MAVS is involved in the development of steatosis, and its inhibition in previously damaged hepatocytes can ameliorate MASLD.
Pharmacokinetics of Generic Pediatric Dolutegravir Dispersible Tablet in Thai Young Children Living With HIV Weighing Below Twenty Kilograms
Authors: Rungsapphaiboon Athiporn , Wacharachaisurapol Noppadol , Anugulruengkitt Suvaporn , Sirikutt Pugpen , Phasomsap Chayapa , Tawan Monta , Saisaengjan Chutima , Na Nakorn Yossawadee , Paiboon Nantika , Songtaweesin Wipaporn Natalie , Tawon Yardpiroon , Cressey Tim R. , Puthanakit Thanyawee ,   on behalf of DTGkids Study Team
Published: May 2024

Introduction:
Dolutegravir (DTG) dispersible tablet (DTG-DT) is a pediatric-friendly formulation. We aimed to describe the pharmacokinetics and virologic responses of generic DTG-DT in children weighing <20 kg.

Methods:
Children living with HIV-1 and <7 years of age weighing 6 to <20 kg were eligible. A generic 10-mg scored DTG-DT was administered to children using 3 weight bands (WB): WB1 (6 to <10 kg), WB2 (10 to <14 kg) and WB3 (14 to <20 kg), at doses of 20 mg (higher than World Health Organization recommendation of 15 mg), 20 mg and 25 mg, respectively. Steady-state intensive pharmacokinetics (PK) was performed in fasting condition with blood sampling at predose and 1, 2, 3, 4, 6 and 24 hours postdose. DTG PK parameters were estimated using a noncompartmental analysis, and DTG trough concentrations (C24) and 24-hour area under the concentration-time curve were calculated. Comparisons were made with ODYSSEY and IMPAACT 2019. And 90% effective concentration of 0.32 mg/L was used as a reference individual DTG C24 concentration.

Results:
From August 2021 to March 2023, 29 Thai children with a median (interquartile range) age of 3.2 (1.5–4.8) years were enrolled; 8 in WB1, 9 in WB2 and 12 in WB3. All children were treatment experienced and 59% had HIV RNA <200 copies/mL. Overall geometric mean (coefficient of variation percentage) DTG C24 was 1.0 (46%) mg/L [WB1, 0.9 (53%); WB2, 0.9 (27%); WB3, 1.2 (51%)]. Geometric mean (coefficient of variation percentage) 24-hour area under the concentration-time curve was 83.2 (24%) mg h/L [WB1, 84.3 (31%); WB2, 76.9 (16%); WB3, 87.6 (25%)]. At weeks 24 and 48, 90% and 92% of participants had plasma HIV RNA <200 copies/mL.

Conclusions:
Generic DTG-DT provided adequate drug exposure in children weighing 6 to <20 kg. The exploratory dose of DTG 20 mg for children weighing 6 to <10 kg showed similar PK parameters to World Health Organization doses in the other WB.
Virtual Access to Quality Dermatology Care: Challenges and Promises
Authors: Ashouri Diana , Fonseca Allene S. 
Published: May 2024

ABSTRACT
Teledermatology is the treatment of skin disease via the electronic transfer of medical information to a provider in a distant location. There are two primary forms of teledermatology, namely, store-and-forward and live/real-time interactive, which are both discussed in this article. During the COVID-19 pandemic, teledermatology has emerged as a powerful tool for inpatient and outpatient care of dermatology patients. This article provides updates on the best approach to optimize the utilization of teledermatology and discusses its benefits, disadvantages, and financial and ethical challenges in the post-COVID-19 era.
Recurring Hidradenocarcinoma of the Lower Extremity
Authors: Dhinsa Harpinder , Bashir Amani , Rajan Anand , Miller Benjamin , Powers Jennifer Gloeckner 
Published: May 2024

ABSTRACT
Hidradenocarcinomas are rare adnexal tumor of the sweat glands. They are typically found on the head and neck with a high rate of recurrence and metastasis. Here, we present a case of a 67-year-old woman who presented with long-standing subcutaneous mass over her right knee. She underwent initial surgical excision with positive margins, and histopathology of the resection specimen was consistent with hidradenocarcinoma. The patient completed 60-Gray adjuvant radiation to the surgical bed postoperatively. Eight months later, the patient returned with a concern for recurrence of the hidradenocarcinoma at the same site. Biopsy confirmed the recurrence, and the malignancy was excised with 2-cm margins along with surgical reconstruction with a local muscle flap. She has not had recurrence at follow-up 1 year after the reconstructive flap. This case highlights the histopathologic nature of hidradenocarcinomas and that, despite local excision and large-dose radiation, malignancy can recur.
Development of a CT-Based comprehensive model combining clinical, radiomics with deep learning for differentiating pulmonary metastases from noncalcified pulmonary hamartomas: a retrospective cohort study
Authors: Liu Yunze , Ren Hong , Pei Yanbin , Shen Leilei , Guo Juntang , Zhou Jian , Li Chengrun , Liu Yang 
Published: May 2024

Background:
Clinical differentiation between pulmonary metastases and noncalcified pulmonary hamartomas (NCPH) often presents challenges, leading to potential misdiagnosis. However, the efficacy of a comprehensive model that integrates clinical features, radiomics, and deep learning (CRDL) for differential diagnosis of these two diseases remains uncertain.

Objective:
This study evaluated the diagnostic efficacy of a CRDL model in differentiating pulmonary metastases from NCPH.

Methods:
The authors retrospectively analyzed the clinical and imaging data of 256 patients from the First Medical Centre of the General Hospital of the People’s Liberation Army (PLA) and 85 patients from Shanghai Changhai Hospital, who were pathologically confirmed pulmonary hamartomas or pulmonary metastases after thoracic surgery. Employing Python 3.7 software suites, the authors extracted radiomic features and deep learning (DL) attributes from patient datasets. The cohort was divided into training set, internal validation set, and external validation set. The diagnostic performance of the constructed models was evaluated using receiver operating characteristic (ROC) curve analysis to determine their effectiveness in differentiating between pulmonary metastases and NCPH.

Results:
Clinical features such as white blood cell count (WBC), platelet count (PLT), history of cancer, carcinoembryonic antigen (CEA) level, tumor marker status, lesion margin characteristics (smooth or blurred), and maximum diameter were found to have diagnostic value in differentiating between the two diseases. In the domains of radiomics and DL. Of the 1130 radiomics features and 512 DL features, 24 and 7, respectively, were selected for model development. The area under the ROC curve (AUC) values for the four groups were 0.980, 0.979, 0.999, and 0.985 in the training set, 0.947, 0.816, 0.934, and 0.952 in the internal validation set, and 0.890, 0.904, 0.923, and 0.938 in the external validation set. This demonstrated that the CRDL model showed the greatest efficacy.

Conclusions:
The comprehensive model incorporating clinical features, radiomics, and DL shows promise for aiding in the differentiation between pulmonary metastases and hamartomas.
Regulatory patterns of Chinese patent medicine for lipid metabolism disorders in patients with type 2 diabetes mellitus complicated by ischemic stroke: A systematic review and network meta-analysis
Authors: Lu Zhenkai , Zhang Xuming , Xie Yanming 
Published: May 2024

Background:
To investigate the regulatory patterns of Chinese patent medicine (CPM) interventions on lipid metabolism disorders in patients with type 2 diabetes mellitus (T2DM) complicated by ischemic stroke.

Methods:
Two researchers independently searched 8 major databases and created a comprehensive database containing all randomized controlled trials (RCTs) that investigated the application of “blood-activating and stasis-removing” CPM in the treatment of stroke combined with T2DM until October 1, 2022. The collected data were compiled and organized in Excel. Quality assessment was performed using the Cochrane 5.3 bias risk assessment tool, and the network meta-analysis was conducted using R software.

Results:
A total of 12 articles were included in the final analysis, covering 4 types of CPM: Naoxintong Capsules (NXT), Tongmai Jiangtang Capsules, Tongxinluo Capsules (TXL), and Yindan Xinnaotong Soft Capsules. Among these, CPM formulations containing herbs with blood-activating and stasis-removing properties were the most commonly used. The results of the network meta-analysis are as follows: (1) the combination of 3 CPM formulations showed superior efficacy in improving total cholesterol levels compared to conventional Western medicine treatment (CT). In particular, Yindan Xinnaotong Soft Capsules + CT (surface under the cumulative ranking curve [SUCRA] = 97.24%) demonstrated the highest efficacy, followed by NXT + CT (SUCRA = 66.23%), and then TXL + CT (SUCRA = 55.16%). (2) TXL + CT treatment exhibited the most promising efficacy in improving triglyceride levels (P < .05), while the effects of the other 3 CPM formulations were not statistically significant. (3) In terms of improving low-density lipoprotein levels, NXT + CT (SUCRA = 82.27%) showed better efficacy than TXL + CT (SUCRA = 73.99%), while the effects of the other 2 CPM formulations were not statistically significant. (4) The combination of CPM formulations and CT resulted in a lower incidence of adverse reactions compared to CT (P < .05).

Conclusion:
The treatment of patients with T2DM complicated by ischemic stroke commonly involved the use of “blood-activating and stasis-removing” herbal medicines. These herbal medicines have shown effectiveness in regulating patients’ blood lipid levels. However, it is crucial to acknowledge that the analysis was influenced by variations in the number and quality of RCTs involving different CPM formulations. Therefore, additional validation through large-scale, high-quality RCT studies is required.
A urethral leiomyoma presenting with dysuria: A rare case report
Authors: Wu Shuo , Min Zhichao , Wu Lingyan , Zhang Mengsi , Wu Lejun 
Published: May 2024

Rationale:
Leiomyoma is a benign smooth muscle tumor which is rarely found in urethra. We hereby report a case of a 44-year-old female who presented with complaints of dysuria.

Patient concerns:
A 44-year-old female patient presented to the urology outpatient clinic with symptoms of dysuria. The patient described the presence of a protrusion from the urethra during urination.

Diagnosis:
Urethral leiomyoma.

Interventions:
Physical examination confirmed a solid urethral mass. CT scan and USG reports indicated that the mass originated from the mid-urethra with vascularity at the base. We performed a complete resection of the urethral mass. The patient was discharged after 3 days of observation.

Outcome:
During a follow-up after 1 month, the patient reported improved urinary flow and no occurrence of hematuria. The patient recovered well after discharge.

Lesson:
Urethral leiomyoma is a rare benign tumor that is often misdiagnosed in clinical practice. Diagnosis requires careful clinical examination. Surgical removal usually works well. It is important to remember that in some cases of acute urinary retention, it can be caused by a complete obstruction of a mass in the urethra. Urologists should be more cautious and experienced in handling such cases.
Exploration of the molecular linkage between endometriosis and Crohn disease by bioinformatics methods
Authors: Zhou Weijie , Su Peizhu , Wang Yilin , Li Zhaotao , Liu Liu 
Published: May 2024

Background:
Endometriosis (EMT) is a common disease in reproductive-age woman and Crohn disease (CD) is a chronic inflammatory disorder in gastrointestinal tract. Previous studies reported that patients with EMT had an increased risk of CD. However, the linkage between EMT and CD remains unclear. In this study, we aimed to investigate the potential molecular mechanism of EMT and CD.

Methods:
The microarray data of EMT and CD were downloaded from Gene Expression Omnibus. Common genes of EMT and CD were obtained to perform the Gene Ontology and Kyoto Encyclopedia of Gene Genomes enrichments. The protein-protein interaction network was constructed by Cytoscape software and the hub genes were identified by CytoHubba plug-in. Finally we predicted the transcription factors (TFs) of hub genes and constructed a TFs-hub genes regulation network.

Results:
A total of 50 common genes were identified. Kyoto Encyclopedia of Gene Genomes enrichment showed that the common genes mainly enriched in MAPK pathway, VEGF pathway, Wnt pathway, TGF-beta pathway, and Ras pathway. Fifteen hub genes were collected from the protein-protein interaction network, including FMOD, FRZB, CPE, SST, ISG15, EFEMP1, KDR, ADRA2A, FZD7, AQP1, IGFBP5, NAMPT, PLUA, FGF9, and FHL2. Among them, FGF9, FZD7, IGFBP5, KDR, and NAMPT were both validated in the other 2 datasets. Finally TFs-hub genes regulation network were constructed.

Conclusion:
Our findings firstly revealed the linkage between EMT and CD, including inflammation, angiogenesis, immune regulation, and cell behaviors, which may lead to the risk of CD in EMT. FGF9, FZD7, IGFBP5, KDR, and NAMPT may closely relate to the linkage.
Management of work stress among arts and science school administrators in Nigeria using rational emotive occupational health coaching: A randomized controlled trial evaluation
Authors: Chinweuba Ngozi Hope , Chigbu Baptista Chinyere , Aham Assumpta C. , Onyi Ifeoma E. , Ezeugo Nneka Chinyere , Anakpua Blessing C. , Enebechi Regina Ijeamasi , Kalu Ijeoma Awa , Eze Nneka Justina , Ugwuanyi Christian Sunday 
Published: May 2024

Background:
The working circumstances of the administrators are appalling due to the nature of education in Nigeria. These administrators put in a lot of overtime to fulfill the expectations of their positions, which stresses them out. But there is no information in the literature about how administrators of science schools deal with their demanding environments. Therefore, the aim of this study was to evaluate how administrators of secondary scientific schools in the Southeast could manage work-related stress by using rational and emotive occupational health coaching.

Methods:
A randomized controlled trial (RCT) experimental design was used for the investigation, with 106 people divided into 2 groups–one for the intervention and one for the control. A selection of these participants came from southeast Nigerian special scientific schools. The Occupational Stress Index (OSI) and the Perceived Stress Scale (PSS) served as the foundation for our data collection procedure. A posttest was given following the 12-week intervention, and then there was a 2-month follow-up assessment. Repeated analysis of variance (ANOVA) was utilized to ascertain the effects both within and across groups.

Results:
It was revealed that rational emotive occupational health coaching had significant effect on the management of work stress among southeast secondary arts and science school administrators, F (2, 208) = 1452.484, P = <.050, ŋ2 = .933, and F (1, 104) = 18076.988, P = <.050, ŋ2 = .994).

Conclusion:
The management of work stress among southeast secondary arts and science school administrators was significantly improved through rational emotive occupational health coaching.
A rare case report of bilateral vestibulopathy due to otosyphilis
Authors: Gu Huanhuan , Xu Yixin , Xu Jin , Zhuang Jianhua 
Published: May 2024

Rationale:
Bilateral vestibulopathy is an important cause of imbalance. There are multiple etiologies of bilateral vestibulopathy (BVP), but reports of BVP due to otosyphilis are rare.

Patient concerns:
A 39-year-old male was referred to our medical center due to vertigo, persistent dizziness and gait disturbance for 2 months.

Diagnoses:
Bilateral vestibulopathy due to otosyphilis was considered in this case, as confirmed through analyses of vestibular function, laboratory tests, and penicillin treatment.

Interventions:
The patient was was treated with a high dose of penicillin G (24 × 106 IU/d) for 14 days.

Outcomes:
The patient’s symptoms had improved greatly following treatment, with dizziness and gait disturbance having completely resolved at 3 months following hospital discharge.

Lessons:
Bilateral vestibulopathy should be considered when evaluating patients with acute or subacute persistent dizziness. Clinicians should also be aware of the potential for otosyphilis among patients who report BVP.
The knowledge structure and research trends between light and myopia: A bibliometric analysis from 1981 to 2024
Authors: Zhou Shuaibing , Niu Yueyue , Li Xuejiao , Yue Juan , Zhang Hongmin 
Published: May 2024

Background:
This bibliometric analysis explored the knowledge structure of and research trends in the relationship between light and myopia.

Methods:
Relevant literature published from 1981 to 2024 was collected from the Web of Science Core Collection database. Visual maps were generated using CiteSpace and VOSviewer. We analyzed the included studies in terms of the annual publication count, countries, institutional affiliations, prolific authors, source journals, top 10 most cited articles, keyword co-occurrence, and cocitations.

Results:
A total of 525 papers examining the relationship between light and myopia published between 1981 and 2024 were collected. The United States ranked first in terms of the number of publications and actively engaged in international cooperation with other countries. The New England College of Optometry, which is located in the United States, was the most active institution and ranked first in terms of the number of publications. Schaeffel Frank was the most prolific author. The most active journal in the field was Investigative Ophthalmology & Visual Science. The most frequently cited paper in the included studies was written by Saw, SM and was published in 2002. The most common keywords in basic research included “refractive error,” “longitudinal chromatic aberration,” and “compensation.” The most common keywords in clinical research mainly included “light exposure,” “school,” and “outdoor activity.” The current research hotspots in this field are “progression,” “refractive development,” and “light exposure.” The cocitation analysis generated 17 clusters.

Conclusion:
This study is the first to use bibliometric methods to analyze existing research on the relationship between light and myopia. In recent years, the intensity and wavelength of light have become research hotspots in the field. Further research on light of different intensities and wavelengths may provide new perspectives in the future for designing more effective treatments and interventions to reduce the incidence of myopia.