bluuebunny/crossref_metadata_2025_split huggingface dataset:
Modulation of Hepatocyte Growth Factor Secretion in Human Female Reproductive Tract Stromal Fibroblasts by Poly (I:C) and Estradiol
Authors: Coleman Kimberly D. , Ghosh Mimi , Crist Sarah G. , Wright Jacqueline A. , Rossoll Richard M. , Wira Charles R. , Fahey John V. 
Published: August 2011

Citation Coleman KD, Ghosh M, Crist SG, Wright JA, Rossoll RM, Wira CR, Fahey JV. Modulation of Hepatocyte Growth Factor secretion in human female reproductive tract stromal fibroblasts by poly (I:C) and estradiol. Am J Reprod Immunol 2012; 67: 44–53ProblemHepatocyte Growth Factor (HGF) secretion facilitates epithelial cell growth and development in the female reproductive tract (FRT) and may contribute to pathological conditions such as cancer and endometriosis. We hypothesized that estradiol and poly (I:C), a synthetic RNA mimic, may have a regulatory effect on HGF secretion by stromal fibroblasts from FRT tissues.Method of studyFollowing hysterectomies, normal tissue from the uterus, endocervix, and ectocervix were dispersed into stromal cell fractions by enzymatic digestion and differential filtering. Stromal fibroblasts were cultured and treated with estradiol and/or poly (I:C), and conditioned media were analyzed for HGF via enzyme‐linked immunosorbent assay.ResultsTreating uterine fibroblasts with estradiol or poly (I:C) significantly increased HGF secretion. When uterine fibroblasts were co‐treated with estradiol and poly (I:C), the effect on HGF secretion was additive. In contrast, stromal fibroblasts from endo‐ and ecto‐cervix were unresponsive to estradiol, but were stimulated to secrete HGF by poly (I:C).ConclusionHGF secretion is uniquely regulated in the uterus, but not in ecto‐ and endo‐cervix, by estradiol. Moreover, potential viral pathogens further induce HGF. These findings have potential applications in understanding both hormonal regulation of normal tissue as well as the role of HGF in tumorogenesis, endometriosis, and human immunodeficiency virus infection.
Clozapine-induced palilalia?
Authors: Azevedo Jacinto C. , Lopes Rui , Curral Rosário , Esteves Manuel F. , Coelho Rui , Roma-Torres Antonio 
Published: August 2011

Introduction: Palilalia is an acquired speech disorder characterised by involuntary and spontaneous repetition of words or phrases two or more times in a row. It can occur in a variety of disorders including postencephalic parkinsonism, pseudobulbar palsy, schizophrenia, Gilles de la Tourette syndrome and others.Clinical Case: We describe a case of a 28-year-old man with refractory schizophrenia that developed palilalia with 300 mg of clozapine. In the patient evaluation we found unspecific alterations in the electroencephalogram, with normal blood tests and cerebral magnetic resonance imaging. Palilalia disappeared with lowering doses of clozapine.Discussion: The appearance of palilalia induced by clozapine is a rare pharmacologic side-effect which physicians should be familiarised with when evaluating this symptom presentation.
Is cognitive behavioural therapy an effective complement to antidepressants in adolescents? A meta-analysis
Authors: Calati Raffaella , Pedrini Laura , Alighieri Sara , Alvarez Mariela Ivana , Desideri Lorenzo , Durante Daniele , Favero Federica , Iero Luisa , Magnani Giulia , Pericoli Valentina , Polmonari Alexia , Raggini Roberta , Raimondi Elena , Riboni Valentina , Scaduto Maria Cristina , Serretti Alessandro , De Girolamo Giovanni 
Published: August 2011

Calati R, Pedrini L, Alighieri S, Alvarez MI, Desideri L, Durante D, Favero F, Iero L, Magnani G, Pericoli V, Polmonari A, Raggini R, Raimondi E, Riboni V, Scaduto MC, Serretti A, De Girolamo G. Is cognitive behavioural therapy an effective complement to antidepressants in adolescents? A meta-analysis.Objective: Evidence on effectiveness of combined treatments versus antidepressants alone in adolescents consists on a few studies in both major depressive and anxiety disorders. A meta-analysis of randomised 12-week follow-up studies in which antidepressant treatment was compared to combined treatment consisting of the same antidepressant with cognitive behavioural therapy has been performed.Methods: Data were entered into the Cochrane Collaboration Review Manager software and were analysed within a random effect framework. A quality assessment has been performed through Jadad Scale.Results: Higher global functioning at the Children's Global Assessment Scale was found in the combined treatment group (p < 0.0001) as well as higher improvement at the Clinical Global Impressions Improvement Scale (p = 0.04). No benefit of combined treatment was found on depressive symptomatology at the Children's Depression Rating Scale – Revised.Conclusion: Combined treatment seems to be more effective than antidepressant alone on global functioning and general improvement in adolescents with major depressive and anxiety disorders.
Complete denture wearing and fractures among edentulous patients treated in university clinics
Authors: Takamiya Aline S. , Monteiro Douglas R. , Marra Juliê , Compagnoni Marco A. , Barbosa Debora B. 
Published: August 2011

doi: 10.1111/j.1741‐2358.2011.00551.x

Complete denture wearing and fractures among edentulous patients treated in university clinicsObjective:  The prevalence of wearing and fracture of complete dentures was evaluated among edentulous patients treated in two dental schools in Brazil.Background:  Acceptance and wearing of complete dentures are related to adaptive behaviour of edentulous patients. However, one reason that could interfere with the wearing dentures is their potential to fracture, which is still a common complication in denture rehabilitation practice.Material and methods:  Two hundred and twenty‐four edentulous patients rehabilitated with complete dentures from 2000 to 2005 in Araçatuba and Araraquara Dental School, University of State of São Paulo, were assessed in 2006 and 2007 to answer a questionnaire about wearing and fracture of their dentures. Statistical analysis were performed using Epi Info software and chi‐squared test to compare maxillary and mandibular data (α = 0.05).Results:  Almost 26% of the patients did not wear their dentures, and among the remainder, the majority wore the maxillary denture. About 30% of the dentures were fractured, with higher prevalence in the maxillary arch (p = 0.003).Conclusions:  Discontinuation of wearing dentures was quite high, especially considering the treatment which was carried out in university clinics. Prevalence of fractures was also high, greater for the maxillary denture, and was one of the main reasons for non‐wearing of complete dentures.
Targeted therapies in the treatment of gastric cancer
Authors: NGEOW Joanne , TAN Iain Beehuat , CHOO Su Pin 
Published: August 2011

AbstractGastric cancer (GC) constitutes a major cause of cancer deaths worldwide. Recent improvements in both surgical techniques and adjuvant and neoadjuvant radiotherapy and chemotherapy approaches have increased the survival of patients with loco‐regional disease. However most patients with GC have advanced disease either at diagnosis or at follow up. Despite recent advances in the treatment of advanced disease, these patients still have poor outcomes. An emerging understanding of the molecular pathways that characterize cell growth, cell cycle, apoptosis, angiogenesis and invasion has provided novel targets in cancer therapy. In this review we describe the current status of targeted therapies in the treatment of GC. These therapeutic strategies include epidermal growth factor receptor inhibitors, antiangiogenic agents, cell cycle inhibitors, apoptosis, promoters and matrix metalloproteinases inhibitors.
Predictive factors for detecting malignancy in central and lateral cervical lymph nodes in papillary carcinoma of the thyroid
Authors: ARIBAŞ Bilgin Kadri , ARDA Kemal , ÇİLEDAĞ Nazan , AKTAŞ Elif , ÇETİNDAĞ Mehmet Faik 
Published: August 2011

AbstractAim:  To determine the factors for predicting malignant diagnosis and limitations in ultrasonography guided fine‐needle aspiration cytology of central and lateral cervical lymph nodes in patients with primary differentiated thyroid papillary carcinoma.Methods:  Biopsies of cervical lymph nodes were performed in 120 patients, 31 of whom had subsequent surgical diagnoses. Factors examined were patient's age and gender of the patients, location (central and lateral compartments), hypoechogenicity with loss of hilum, microcalcification, cystic feature, minimum and maximum diameters and index value (minimum/maximum diameter).Results:  The mean minimum diameter and index value of the lymph nodes were 9.9 ± 4.9 mm and 0.60 ± 0.19, respectively. Microcalcifications and cystic parts were specific findings with rates of 93.9% and 95.1%, respectively. Microcalcification, cystic feature, minimum diameter and index value were poor predictors of malignancy. The predictors were central location (P = 0.031) and hypoechogenicity with loss of hilum in lateral neck (P = 0.019). Central nodes led to a major problem for biopsy success due to postoperative changes and anatomic position. Nondiagnostic (30%) nodes were therefore mostly central.Conclusion:  The involvement of the central neck should be a major indication of lymph node biopsy and pathological diagnosis regardless of the imaging findings. In the lateral compartment, hypoechogenicity with loss of hilum, microcalcifications, cystic parts and an index value ≥ 0.51 are indications of a lymph node biopsy to rule out malignancy.
Coincidence of GIST and pancreatic endocrine neoplasm in neurofibromatosis
Authors: DOMINGUEZ‐COMESAÑA Elias , TOME‐ESPIÑEIRO Catherine , ULLA‐ROCHA Jose L , LORENZO‐LORENZO Isabel , LEDE‐FERNANDEZ Angel , PORTELA‐SERRA Jose L 
Published: August 2011

AbstractCarcinoids of the ampulla of Vater are infrequent tumors of which a quarter of cases have been detected in patients with type I neurofibromatosis. This hereditary disease is also associated with gastrointestinal stromal tumors (GIST). However, the coincidence of these three entities together have only been formerly detected in five cases. A 53 year‐old female patient, diagnosed with type I neurofibromatosis, with a malignant carcinoid of ampulla of Vater and multiple gastrointestinal stromal tumors in the duodenum and jejunum, was treated with total pancreatectomy and the excision of her intestinal tumors. Five‐years on, a follow‐up showed the patient to be well, and free from tumor recurrence. The coexistence of an ampullary carcinoid tumor, GIST and neurofibramatosis is very rare. Radical curative surgical resection is a good treatment option, but the optimal management of this is not yet well established.
Second‐line therapy for castrate‐resistant prostate cancer: A literature review
Authors: KAO S C‐H , HOVEY E , MARX G 
Published: August 2011

AbstractDespite a survival benefit in the first‐line treatment of castrate‐resistant prostate cancer (CRPC) with docetaxel, the prognosis remains limited. There are increasing options available for patients with CRPC in the second‐line setting, but there is currently little consensus regarding the optimal treatment. There have been numerous phase II and retrospective studies examining second‐line options in CRPC, including retreatment with docetaxel, mitoxantrone, cyclophosphamide and carboplatin, which can be associated with meaningful responses in a significant minority of patients. In 2010 three randomized trials were published or presented which demonstrated a survival benefit in the second‐line setting. These included cabazitaxel compared with mitoxantrone, sipuleucel‐T (immunotherapy) and abiraterone acetate versus placebo. Ongoing research in the second‐line setting of CRPC to optimize treatment options, with the objectives of survival prolongation, improvement in quality of life and pain management, is still needed.
Exploring consent to randomized placebo‐controlled clinical trials in oncology
Authors: TOLERTON Sarah K , SHAW Joanne , O'REILLY Amanda , DUNN Stewart , BOYLE Frances M 
Published: August 2011

AbstractAims:  Randomized placebo‐controlled trials are critical for advancing knowledge in oncology, yet little is known about optimal communication for informed consent. This study aimed to identify patient preferences for and satisfaction with three consultation styles (information‐focused, emotion‐focused and collaborative) in simulated discussions of four clinical trial concepts (randomization, placebo, tissue analysis and oncologists’ recommendation).Methods:  In total 75 Australian cancer patients and carers, or both, viewed videotaped simulated consultations with a doctor and patient discussing a randomized, placebo‐controlled trial. Their satisfaction and preferences for both consultation style and information were assessed. The patients’ characteristics and decision‐making preferences were also evaluated as potential predictors for consultation style preference.Results:  Participants preferred a collaborative consultation style when discussing randomization (74.6%), placebo (71.4%) and oncologist's recommendation (77%). However an emotion‐focused consultation style was preferred when discussing tissue analysis (81%). The participants represented a highly information‐seeking group, although most favoured collaborative or passive roles in treatment decision‐making. Limited variables were identified that predict consultation style preference.Conclusion:  While supporting the value of a collaborative approach to clinical trial communications, the study finding that tissue analysis requires a more emotion‐focused approach highlights a new focus for trial communication and confirms the need for doctors to remain flexible in their consultation style.
THE EFFECTS OF WHEAT FLOUR SUBSTITUTION WITH GRAPE SEED FLOUR ON THE RHEOLOGICAL PARAMETERS OF THE DOUGH ASSESSED BY MIXOLAB
Authors: MIRONEASA SILVIA , CODINĂ GEORGIANA GABRIELA , MIRONEASA COSTEL 
Published: August 2011

ABSTRACTThe purpose of this investigation was to study the effect of grape seed flour (GSF) addition at the levels of 3, 5 and 7 g/100 g on the rheological behavior of the dough obtained from four types of wheat flour differentiated from a quality point of view. The rheological properties of the dough, substituted with GSF from the Aligoté variety, were recorded in the Mixolab device. The substitution has the effect of decreasing the Falling Number index simultaneously with the increase of the substitution level. The effects on the rheological properties are: the decrease of the dough's opposed torque, the increase of the dough's stability, the increase of the gelatinization temperature and the increase of the dough's opposed torque at the starch gelling, obviously improving the rheological properties of the dough, obtained from these flour mixtures. The results demonstrate the potential GSF in development composite flours.PRACTICAL APPLICATIONSThis article brings into discussion the changes occurring as a result of the substitution of wheat flour with grape seed flour (GSF) in the rheological characteristics of wheat flour dough. The effects of the substitution level of basic wheat flour with GSF on the rheological properties of dough show that GSF can be an excellent source of food ingredient, which technological functionality is worth observing. This study can contribute to the development of new bread‐making products, improving their quality and providing health benefits.
PHYSICS AND TACTILE PERCEPTION OF FLUID‐COVERED SURFACES
Authors: GUEST STEVE , MEHRABYAN ANAHIT , ESSICK GREG , PHILLIPS NICOLA , HOPKINSON ANDREW , MCGLONE FRANCIS 
Published: August 2011

ABSTRACTLittle is known about the linkage between the physical properties of fluids and how they are perceived. Therefore, 15 fluids with diverse rheologies were characterized physically by three participants via a novel “force plate” (FP) device. Perceptual ratings were made by 20 participants, of 27 “sensory” attributes (e.g., oily) and 14 “emotional” attributes (e.g., arousing). Factor analyses decomposed 14 physical measures obtained from the FP into factors approximating friction, normal vibration, and tangential vibration; the sensory attributes into watery, textured, slick, silken and viscous factors; and the emotional attributes into factors labeled pleasant, sensual and harsh. Pleasant and harsh were related to textured and silken. Fluids perceived as more watery elicited greater normal and tangential vibration and less friction, whereas high viscous scores were associated with lower vibration factor scores and increasing friction. These results emphasize the complex perceptual nature of fluid‐coated surfaces as compared with dry, solid surfaces.PRACTICAL APPLICATIONSIn developing consumer products that are fluid‐based (e.g., various foods or cosmetic preparations), it is desirable to reach an end goal in terms of how the fluid feels. This is achieved primarily by altering the physical composition of the fluid. The reported research established relationships between the percepts and physical composition of a diverse set of fluids. These relationships allow early insights concerning how one might formulate a product to produce a given, desirable, percept.
Hearts and Minds Project: A breastfeeding curriculum intervention to improve the education outcomes for nutrition and dietetics graduates
Authors: RADCLIFFE Barbara , PAYNE Jan 
Published: August 2011

AbstractAim:  Dietitian nutritionists play an important role in supporting and promoting breastfeeding. Improving undergraduate training to create a competent and motivated workforce to deliver these outcomes has been recommended. This study evaluated a breastfeeding curriculum intervention designed to improve knowledge, attitudes and beliefs, and increase graduates' motivation to support breastfeeding into the future.Methods:  Final‐year students studying nutrition and dietetics were surveyed at baseline in 2005 and post‐intervention in 2010. Questions related to student profile, breastfeeding knowledge, attitudes and beliefs, perceived professional role in breastfeeding support, intentions to support breastfeeding in the future and perceptions of the breastfeeding curriculum. Curriculum interventions were based on relevant evidence including recommendations from the baseline survey report, a gap analysis of existing curriculum, previous literature identifying key barriers to the support of breastfeeding by health professionals and learning and behaviour change theories and approaches.Results:  General improvements in knowledge and attitudes and beliefs were found over the intervention period, although knowledge gaps remained on the risks associated with not breastfeeding for mothers and infants and when to recommend the cessation of breastfeeding. A significant increase was found in the percentage of respondents agreeing that their studies had engendered a strong interest in work involving breastfeeding. Significant improvements were also seen in student perceptions of the degree to which breastfeeding was addressed in the dietetic course.Conclusion:  Curriculum interventions can effectively influence new graduates' future intention to support and promote breastfeeding if they address knowledge gaps, attitudes, beliefs and perceived social concerns about breastfeeding promotion.
Effects of hyperoxic ventilation on 6‐h survival at the critical haemoglobin concentration aggravated by experimentally induced tachycardia in anaesthetized pigs
Authors: Kertscho H. , Lauscher P. , Raab L. , Zacharowski K. , Meier J. 
Published: August 2011

Abstract
Aim:  Administration of 100% oxygen [hyperoxic ventilation (HV)] has been proven to ameliorate oxygen transport, tissue oxygenation and survival in different models of extreme normovolemic and hypovolemic anaemia. However, up to date, it is unknown whether HV is also able to improve outcome of extreme anaemia if myocardial oxygen consumption is contemporaneously increased by tachycardia. Therefore, we investigated the influence of HV on the 6‐h survival rate during extreme anaemia and aggravated by experimentally induced tachycardia in a prospective, randomized study in a pig model of critical anaemia.
Methods:  After government approval, 14 anesthetized pigs mechanically ventilated on room air were haemodiluted by replacing a certain amount of whole blood with hydroxethyl starch 6% (200.000/0.5) until their individual critical haemoglobin concentration (Hbcrit) was achieved. At Hbcrit, tachycardia (180 bpm) was induced in all animals by atrial pacing. Thereafter, animals were observed for the next 6 h either at room air (FiO2 0.21; group NOX) or during HV (FiO2 1.0; group HOX) without further intervention. As primary outcome parameter of this study, the 6‐h survival rate was selected.
Results:  Hyperoxic ventilation increased the 6‐h survival rate from 14 to 100%. In contrast to the NOX group, macrohaemodynamics and oxygen transport improved in the HOX group during the observation period without apparent adverse effects of HV.
Conclusions:  Hyperoxic ventilation can be considered a safe and effective measure for the optimization of oxygen supply during extreme anaemia and despite concomitant tachycardia within 6 h. Whether HV can also be recommended beyond this period warrants further studies.
A model for using the VIPS framework for person‐centred care for persons with dementia in nursing homes: a qualitative evaluative study
Authors: Røsvik Janne , Kirkevold Marit , Engedal Knut , Brooker Dawn , Kirkevold Øyvind 
Published: August 2011

røsvik j., kirkevold m., engedal k., brooker d. & kirkevold ø. (2011) A model for using the VIPS framework for person‐centred care for persons with dementia in nursing homes: a qualitative evaluative study. International Journal of Older People Nursing6, 227–236doi: 10.1111/j.1748‐3743.2011.00290.xBackground.  The ‘VIPS’ framework sums up the elements in Kitwood’s philosophy of person‐centred care (PCC) for persons with dementia as values, individualised approach, the perspective of the person living with dementia and social environment. There are six indicators for each element.Aim.  To conduct an initial evaluation of a model aimed at facilitating the application of the VIPS framework.Design.  Qualitative evaluative study.Methods.  A model was trialled in a 9‐week pilot study in two nursing homes and evaluated in four focus groups using qualitative content analysis.Results.  Five themes emerged: (1) Legitimacy of the model was secured when central roles were held by nurses representing the majority of the staff; (2) The model facilitated the staff’s use of their knowledge of PCC; (3) Support to the persons holding the internal facilitating roles in the model was needed; (4) The authority of the leading registered nurse in the ward was crucial to support the legitimacy of the model and (5) Form of organisation seemed to be of importance in how the model was experienced.Conclusion.  The model worked best in wards organised with a leading registered nurse who could support an auxiliary nurse holding the facilitating function.