bluuebunny/crossref_metadata_2025_split huggingface dataset:
Long‐Term Comparisons of Photoluminescence Affected by Organic Cations of Formamidinium and Methylammonium in Monophasic Lead Iodide Perovskite Quantum Dots
Authors: Heo Jaeseong , Kim Hyewon , Park Jiyeong , Sasongko Nurwarrohman Andre , Jeong Mincheol , Han Jaeeun , Seo Taeji , Ji Yujeong , Han Jiyoung , Park Myeongkee 
Published: June 2024

AbstractThis study compared the photoluminescence (PL) stabilities of formamidinium (FA) and methylammonium (MA) in lead iodide perovskite quantum dots (QDs). To exclude other factors, such as size and purity, that may affect stability, MAPbI3 and FAPbI3 QDs with nearly identical sizes (~10.0 nm) were synthesized by controlling the ligand concentration and synthesis temperature. Transmission electron microscopy images and X‐ray diffraction patterns confirmed homogeneous single‐phase perovskite structures. Additionally, the bandgaps and sizes of the synthesized QDs closely matched those of the infinite quantum well model, which guaranteed that the photostability was solely caused by the different organic molecules in the two QDs. We analyzed the PL peak centers and full‐width at half maximum of the QDs for 32 days. The enhanced stability of FAPbI3 was found to be caused by the nearly zero redshift (1.615 eV) of its PL peak, in contrast to the redshift (1.685→1.670 eV) of MAPbI3.
Protective efficacy of nafronyl in diabetic retinopathy through targeted inhibition of key enzymes
Authors: Eyush Eyush , Kumar Shivani , Sen Karishma , Sakarwal Anita , Ram Heera , Yadav Dharamveer , Kumar Antresh , Panwar Anil 
Published: June 2024

AbstractDiabetic retinopathy is governed by abnormal apoptosis, increased capillary pressure, and other linked pathology that needs an efficient treatment by multitargeted approaches. Thus, the current study aimed to explore the potential of inhibition of targeted enzymes (DPP4, ACE‐2, and aldose reductase) and free radical scavenging capabilities of selected compounds (nafronyl or naftidrofuryl) through in silico and in vivo investigations. Significant binding energies were observed in complexes of aldolase reductase, angiotensin type 1 receptor, and DPP4 against the nafronyl and sitagliptin more than −7.5 kcal/mol. Further validation of free energy was confirmed by calculations of molecular mechanics Poisson–Boltzmann surface area (MMPBSA), and configurational stabilities examined by PCA (principal component analysis). Additionally, drug‐likeness was examined by the Swiss ADME web tool, which showed significant findings. Consequently, in vivo experimentations showed significant inflammation and alterations in retinal layers of inner plexiform (inner limiting membrane, nerve fibers, and ganglionic cells), inner nuclear layer (bipolar cells and horizontal cells), and photoreceptors cells. Whereas the treatments (nafronyl and sitagliptin) caused significant improvements in the histoarchitecture of the retina. Additionally, the HOMA indices (IR‐insulin resistance, sensitivity, and β cells functioning) and levels of free radicals were significantly altered in the diabetic control group in comparison to intact control. Nafronyl administration showed significant ameliorations in HOMA indices as well as antioxidant levels. Based on the results, it can be concluded that nafronyl efficiently interacts with target enzymes, which may result in potent inhibition and ameliorations in retinal histology as well as glucose homeostasis and antioxidants.
Lithium‐Sulfur‐Batteries under Lean Electrolyte Conditions: Improving Rate Capability by the Choice of the Lithium Salt in Dimethoxyethane‐Hydrofluoroether‐Based Electrolyte
Authors: Kirchhoff Sebastian , Härtel Paul , Dörfler Susanne , Abendroth Thomas , Althues Holger , Kaskel Stefan 
Published: June 2024

AbstractLithium‐sulfur batteries (LSBs) are discussed as the most promising post‐lithium‐ion battery technology due to the high theoretical energy density and the cost‐efficient, environmental‐friendly active material sulfur. Unfortunately, LSBs still suffer from several limitations such as cycle life and rate capability. To overcome these issues, the development of adapted electrolytes is one promising path. Consequently, in this study, we focus on the influence of the lithium salt on the performance of LSBs. In a fixed solvent system without employing LiNO3, five different lithium salts are compared. The electrolyte properties as well as the influence of polysulfides are determined and discussed in relation with the battery performance. Interestingly, although the different salts lead to different electrolyte properties, only a minor influence of the salt is observed at low C‐rates. By performing a rate capability test, however, a strong influence of the lithium salt is detected at high C‐rates, with LiFSI outperforming the other salts. This correlates well with ionic conductivity and a suppressed influence of polysulfides in case of LiFSI. To verify the results, multi‐layered pouch cells were tested under lean electrolyte conditions. The study emphasizes the significance of the lithium salt and provides guidance for electrolyte design under lean electrolyte conditions.
Establishment and evaluation of a new fluorescent probe method based on loop‐mediated isothermal amplification for the detection of Mycobacterium tuberculosis complex
Authors: Batuer Mireguli , Yuan Yue , Yu Mengsi , Meng Cunren 
Published: June 2024

AbstractWe aimed to develop a novel diagnostic method called multiplex fluorescence of loop primer upon self‐dequenching loop‐mediated isothermal amplification (mFLOS‐LAMP) for the rapid detection of Mycobacterium tuberculosis complex (MTBC). A set of specific primers was designed to target the detection of IS1081 and IS6110 genes, which are insertion sequences within the MTBC. The 110 sputum specimens collected were assessed using the established mFLOS‐LAMP method, multiplex polymerase chain reaction, Xpert MTB/RIF, and smear microscopy. The optimal reaction temperature and duration for mFLOS‐LAMP were determined to be 65°C and 30 min, respectively, by optimizing the entire system. The detection sensitivity of mFLOS‐LAMP was 6.0 × 101 CFU/mL, by Bacillus Calmette‐Guerin, and the mFLOS‐LAMP sensitivity of M. tuberculosis H37Rv genomic DNA was 500 fg, and the specificity was 100%. The sensitivity of mFLOS‐LAMP was 94.2% and the specificity was 96.6%, when Xpert MTB/RIF was used as the reference method. There was no statistically significant difference in their detection rate (χ2 = 0, P = 1.000), and the consistency was good (kappa = 0.909, P < 0.001). The receiver operating characteristic analysis yielded the maximum area under the curve of 0.954. The mFLOS‐LAMP method demonstrated high sensitivity and specificity, allowing for swift and accurate detection of MTBC.
Functional role of geminivirus encoded proteins in the host: Past and present
Authors: Kamal Hira , Zafar Muhammad Mubashar , Razzaq Abdul , Parvaiz Aqsa , Ercisli Sezai , Qiao Fei , Jiang Xuefei 
Published: June 2024

AbstractDuring plant–pathogen interaction, plant exhibits a strong defense system utilizing diverse groups of proteins to suppress the infection and subsequent establishment of the pathogen. However, in response, pathogens trigger an anti‐silencing mechanism to overcome the host defense machinery. Among plant viruses, geminiviruses are the second largest virus family with a worldwide distribution and continue to be production constraints to food, feed, and fiber crops. These viruses are spread by a diverse group of insects, predominantly by whiteflies, and are characterized by a single‐stranded DNA (ssDNA) genome coding for four to eight proteins that facilitate viral infection. The most effective means to managing these viruses is through an integrated disease management strategy that includes virus‐resistant cultivars, vector management, and cultural practices. Dynamic changes in this virus family enable the species to manipulate their genome organization to respond to external changes in the environment. Therefore, the evolutionary nature of geminiviruses leads to new and novel approaches for developing virus‐resistant cultivars and it is essential to study molecular ecology and evolution of geminiviruses. This review summarizes the multifunctionality of each geminivirus‐encoded protein. These protein‐based interactions trigger the abrupt changes in the host methyl cycle and signaling pathways that turn over protein normal production and impair the plant antiviral defense system. Studying these geminivirus interactions localized at cytoplasm‐nucleus could reveal a more clear picture of host–pathogen relation. Data collected from this antagonistic relationship among geminivirus, vector, and its host, will provide extensive knowledge on their virulence mode and diversity with climate change.
Development of a biotechnology process for the production of a novel hyperglycosylated long‐acting recombinant bovine follicle‐stimulating hormone
Authors: Villarraza Javier , Antuña Sebastián , Tardivo María Belén , Rodríguez María Celeste , Díaz Pablo Uriel , Notaro Ulises Sebastián , Ortega Hugo Héctor , Prieto Claudio , Ceaglio Natalia 
Published: June 2024

AbstractFollicle‐stimulating hormone (FSH) is an important protein used for bovine ovarian hyperstimulation in multiple ovulation and embryo transfer technology (MOET). Several attempts to produce bovine FSH (bFSH) in recombinant systems have been reported, nonetheless, up to date, the most commonly used products are partially purified preparations derived from porcine or ovine (pFSH or oFSH) pituitaries. Here we describe the development of a biotechnology process to produce a novel, hyperglycosylated, long‐acting recombinant bFSH (LA‐rbFSH) by fusing copies of a highly O‐glycosylated peptide. LA‐rbFSH and a nonmodified version (rbFSH) were produced in suspension CHO cell cultures and purified by IMAC with high purity levels (>99%). LA‐rbFSH presented a higher glycosylation degree and sialic acid content than rbFSH. It also demonstrated a notable improvement in pharmacokinetic properties after administration to rats, including a higher concentration in plasma and a significant (seven‐fold) reduction in apparent clearance (CLapp). In addition, the in vivo specific bioactivity of LA‐rbFSH in rats was 2.4‐fold higher compared to rbFSH. These results postulate this new molecule as an attractive substitute for commercially available porcine pituitary‐derived products.
Comparative analysis of brain language templates with primary language areas detected from presurgical fMRI of brain tumor patients
Authors: Lee Jina , Kumar Vinodh A. , Teo Jian Ming , Eldaya Rami W. , Hou Ping , Noll Kyle R. , Ferguson Sherise D. , Prabhu Sujit S. , Liu Ho‐Ling 
Published: June 2024

AbstractIntroductionFunctional brain templates are often used in the analysis of clinical functional MRI (fMRI) studies. However, these templates are mostly built based on anatomy or fMRI of healthy subjects, which have not been fully vetted in clinical cohorts. Our aim was to evaluate language templates by comparing with primary language areas (PLAs) detected from presurgical fMRI of brain tumor patients.MethodsFour language templates (A–D) based on anatomy, task‐based fMRI, resting‐state fMRI, and meta‐analysis, respectively, were compared with PLAs detected by fMRI with word generation and sentence completion paradigms. For each template, the fraction of PLA activations enclosed by the template (positive inclusion fraction, [PIF]), the fraction of activations within the template but that did not belong to PLAs (false inclusion fraction, [FIF]), and their Dice similarity coefficient (DSC) with PLA activations were calculated.ResultsFor anterior PLAs, Template A had the greatest PIF (median, 0.95), whereas Template D had both the lowest FIF (median, 0.074), and the highest DSC (median, 0.30), which were all significant compared to other templates. For posterior PLAs, Templates B and D had similar PIF (median, 0.91 and 0.90, respectively) and DSC (both medians, 0.059), which were all significantly higher than that of Template C. Templates B and C had significantly lower FIF (median, 0.061 and 0.054, respectively) compared to Template D.ConclusionThis study demonstrated significant differences between language templates in their inclusiveness of and spatial agreement with the PLAs detected in the presurgical fMRI of the patient cohort. These findings may help guide the selection of language templates tailored to their applications in clinical fMRI studies.
Shaping supply chain ethical leadership via green intellectual capital: The mediating role of ambidextrous environmental strategy
Authors: Liu Shasha , Jiang Wenbo , Liu Yingyi , Feng Taiwen 
Published: June 2024

AbstractConsidering the serious environmental uncertainties and challenges facing the supply chain, the focal firm with supply chain ethical leadership (SCEL) can effectively coordinate the economic and environmental relationships and achieve sustainable supply chain. Although its importance, the knowledge of how to shape SCEL is limited. Based on signaling theory, we explore that the mechanism and boundary conditions of green intellectual capital (GIC) shape SCEL via ambidextrous environmental strategy and the moderating role of supply chain trust. Using 317 survey data from Chinese manufacturers, we conducted the hierarchical regression analysis to test the hypotheses. Our results reveal that both green human capital and green relational capital have direct and indirect impacts on SCEL, while green structural capital only contributes to SCEL via ambidextrous environmental strategy. Moreover, when the degree of supply chain trust increases, the effect of ambidextrous environmental strategy on SCEL becomes stronger. This research contributes to the supply chain leadership and environmental strategy literature and provides novel insights into better understanding the mechanisms of shaping SCEL. Managers would do better to shape SCEL by sending reliable signals of GIC and ambidextrous environmental strategy.
Treatment patterns and survival outcomes of patients admitted to the intensive care unit due to immune‐related adverse events of immune checkpoint inhibitors
Authors: Lin Lishi , Houwink Aletta P. I. , van Dieren Jolanda M. , Wolthuis Esther K. , van Thienen Johannes V. , van der Heijden Michiel S. , Haanen John B. A. G. , Beijnen Jos H. , Huitema Alwin D. R. 
Published: June 2024

AbstractIntroductionSevere immune‐related adverse events (irAEs) due to immune checkpoint inhibitors (ICIs) can lead to admission to the intensive care unit (ICU). In this retrospective study, we determined the incidence, treatment patterns and survival outcomes of this patient population at a comprehensive cancer center.MethodsAll patients admitted to the ICU due to irAEs from ICI treatment between January 2015 and July 2022 were included. Descriptive statistics were reported on patient characteristics and treatment patterns during hospital admission. Overall survival (OS) from the time of ICU discharge to death was estimated using the Kaplan–Meier method.ResultsOver the study period, 5561 patients received at least one ICI administration, of which 32 patients (0.6%) were admitted to the ICU due to irAEs. Twenty patients were treated with anti‐PD‐1 plus anti‐CTLA‐4 treatment, whereas 12 patients were treated with ICI monotherapy. The type of irAEs were de novo diabetes‐related ketoacidosis (n = 8), immune‐related gastrointestinal toxicity (n = 8), myocarditis or myositis (n = 10), nephritis (n = 3), pneumonitis (n = 2), and myelitis (n = 1). The median duration of ICU admission was 3 days (interquartile range: 2–6 days). Three patients died during ICU admission. The median OS of the patients who were discharged from the ICU was 18 months (95% confidence interval, 5.0—NA).ConclusionThe incidence of irAEs leading to ICU admission in patients treated with ICI was low in this study. ICU mortality due to irAEs was low and a subset of this patient population even had long‐term survival.
Pathological and clinical outcomes following neoadjuvant dual HER2 therapy for early‐stage breast cancer: An Australian institutional real‐world experience
Authors: Narayanan Sathya , Ngui Nicholas K. , Kinchington Ben , Choi Joseph Do Woong , Hughes Thomas Michael D. , Rutovitz Josie , Hasovits Csilla , Nahar Kazi J. , Edirimanne Senarath , Marx Gavin 
Published: June 2024

AbstractAimThere has been significant progress made in developing novel targeted therapies in the neoadjuvant setting for non‐metastatic HER2‐positive breast cancer, which may be used in combination with conventional chemotherapy to optimise pathological responses at surgery. However, these therapies, particularly the chemotherapeutic components, may portend significant and long‐lasting toxicity. Hence, de‐escalation of treatment intensity has been an area of interest and was evaluated in the phase II NeoSphere study. Herein, we report the real‐world pathological and survival outcomes from neoadjuvant taxane and dual HER2 blockade recorded at our centre.MethodsThis was a retrospective cohort study of patients receiving neoadjuvant pertuzumab, trastuzumab and taxane chemotherapy for non‐metastatic HER2‐positive breast cancer at a single centre in Sydney, Australia. We collected data pertaining to baseline demographic characteristics, pathological response rates, post‐surgical prescribing patterns and also undertook survival analyses for invasive disease‐free survival (iDFS) as well as exploratory analyses for correlations between pre‐specified clinicopathologic factors and pathological response at surgery.ResultsOur population was largely similar at baseline to the NeoSphere study. 71 patients were included in the final analysis. 61% achieved a pathological complete response (pCR). Three patients received conventional chemotherapy in the adjuvant setting. 92% of included patients were alive and disease‐free at 3 years of follow‐up. Only 3 events of recurrence or death were recorded at a median follow‐up of 32 months. No significant difference in iDFS was noted between patients achieving pCR and those with residual disease at surgery.ConclusionThis study demonstrates that de‐escalated adjuvant treatment for HER2‐positive early breast cancer achieved favourable pathological and long‐term outcomes comparable to large trials, some utilising more intensive chemotherapeutic components.
Discriminating atypical parotid carcinoma and pleomorphic adenoma utilizing extracellular volume fraction and arterial enhancement fraction derived from contrast‐enhanced CT imaging: A multicenter study
Authors: Xu Zhen‐Yu , Huang Lin‐Wen , Yang Yun‐Jun , Cai Zhi‐Ping , Chen Mei‐Lin , Lu Rui‐Liang , Ouyang Yong‐Xi , Hong Zhen‐Kai , Huang Wei‐Jun , Xu Zhi‐Feng 
Published: June 2024

AbstractObjectivesTo investigate the added value of extracellular volume fraction (ECV) and arterial enhancement fraction (AEF) derived from enhanced CT to conventional image and clinical features for differentiating between pleomorphic adenoma (PA) and atypical parotid adenocarcinoma (PCA) pre‐operation.MethodsFrom January 2010 to October 2023, a total of 187 cases of parotid tumors were recruited, and divided into training cohort (102 PAs and 51 PCAs) and testing cohort (24 PAs and 10 atypical PCAs). Clinical and CT image features of tumor were assessed. Both enhanced CT‐derived ECV and AEF were calculated. Univariate analysis identified variables with statistically significant differences between the two subgroups in the training cohort. Multivariate logistic regression analysis with the forward variable selection method was used to build four models (clinical model, clinical model+ECV, clinical model+AEF, and combined model). Diagnostic performances were evaluated using receiver operating characteristic (ROC) curve analyses. Delong's test compared model differences, and calibration curve and decision curve analysis (DCA) assessed calibration and clinical application.ResultsAge and boundary were chosen to build clinical model, and to construct its ROC curve. Amalgamating the clinical model, ECV, and AEF to establish a combined model demonstrated superior diagnostic effectiveness compared to the clinical model in both the training and test cohorts (AUC = 0.888, 0.867). There was a significant statistical difference between the combined model and the clinical model in the training cohort (p = 0.0145).ConclusionsECV and AEF are helpful in differentiating PA and atypical PCA, and integrating clinical and CT image features can further improve the diagnostic performance.
Sex‐based immune microenvironmental feature heterogeneity in response to PD‐1 blockade in combination with chemotherapy for patients with untreated advanced non‐small‐cell lung cancer
Authors: Yu Xiaofeng , You Zhaolei , Liu Ying , Fang Jian , Zhao Qi , Sun Zhihong , Song Yingjian , Liu Jie , Sun Chengming 
Published: June 2024

AbstractBackgroundTo investigate the sex‐based heterogeneity of immune microenvironmental feature and its impact on the response to first‐line PD‐1 blockade plus chemotherapy in patients with driver‐negative advanced or metastatic non‐small‐cell lung cancer (NSCLC).Patients and MethodsA total of 439 patients with advanced NSCLC treated with first‐line PD‐1 blockade plus chemotherapy or chemotherapy were identified. Differences in clinical outcomes between female and male patients were determined using Kaplan–Meier curves. Neoantigen burden and five immune microenvironmental markers expression including PD‐L1, CD4, CD8, FOXP3, and CD68 were compared between two groups.ResultsOf 175 eligible patients, 89 received PD‐1 blockade plus chemotherapy and 86 received first‐line chemotherapy. Forty five were women (25.7%) and 130 were men (74.3%). Female patients received first‐line PD‐1 blockade in combination with chemotherapy had dramatically better ORR (85.2% vs. 53.2%; p = 0.009), PFS (23.7 vs. 7.3 months; p = 0.013), and OS (46.2 vs. 20.0 months; p = 0.004) than males. Treatment outcomes were similar between females and males in chemotherapy group. Multivariate analyses showed that sex was the independent prognostic factor for patients received PD‐1 blockade combined with chemotherapy. Although female patients had significantly lower tumor mutational and neoantigen burden than males, pretreatment tumor tissues of female patients had markedly higher CD4, CD4/FOXP3, and CD4/FOXP3/PD‐L1 expression level than male patients.ConclusionsFemale patients with untreated advanced or metastatic NSCLC would derive a larger benefit from PD‐1 blockade in combination with chemotherapy than males. The biological significances of heterogeneity of tumor immune microenvironmental features between them need further investigation.
RSM and ANN Comparative Modelling with a Granulation Treatment in Mixed Waters
Authors: Sanchez‐Sanchez Celina , Morales‐Rivera Juan , Moeller‐Chávez Gabriela , Moreno‐Rodríguez Ernestina , Flores‐Gómez Jean 
Published: June 2024

AbstractA Box‐Behnken design was used for the analysis using a gray wolf optimizer (GWO)‐coupled artificial neural network (ANN) model and response surface methodology (RSM) to analyze the effect of three operating parameters (volumetric exchange ratio [VER], aeration rate [AR], and cycle time [CT]) manipulated during an aerobic granular sludge process (AGS) sequencing batch reactor on modeling the removal of chemical oxygen demand (COD) in mixed wastewater. The most efficient architecture for COD showed the highest efficiency for modeling the AGS. The RSM model and plot results indicate that the CT and AR were the most influential on COD removal efficiency. When compared with models with statistical indices, GWO‐ANN demonstrated higher performance compared to RSM.