bluuebunny/crossref_metadata_2025_split huggingface dataset:
Systematic review and meta-analysis of outcomes following pathological complete response to neoadjuvant chemoradiotherapy for rectal cancer
Authors: Martin S T , Heneghan H M , Winter D C 
Published: February 2012

Abstract

Background
Following neoadjuvant chemoradiotherapy (CRT) and interval proctectomy, 15–20 per cent of patients are found to have a pathological complete response (pCR) to combined multimodal therapy, but controversy persists about whether this yields a survival benefit. This systematic review evaluated current evidence regarding long-term oncological outcomes in patients found to have a pCR to neoadjuvant CRT.

Methods
Three major databases (PubMed, MEDLINE and the Cochrane Library) were searched. The systematic review included all original articles reporting long-term outcomes in patients with rectal cancer who had a pCR to neoadjuvant CRT, published in English, from January 1950 to March 2011.

Results
A total of 724 studies were identified for screening. After applying inclusion and exclusion criteria, 16 studies involving 3363 patients (1263 with pCR and 2100 without) were included (mean age 60 years, 65·0 per cent men). Some 73·4 per cent had a sphincter-saving procedure. Mean follow-up was 55·5 (range 40–87) months. For patients with a pCR, the weighted mean local recurrence rate was 0·7 (range 0–2·6) per cent. Distant failure was observed in 8·7 per cent. Five-year overall and disease-free survival rates were 90·2 and 87·0 per cent respectively. Compared with non-responders, a pCR was associated with fewer local recurrences (odds ratio (OR) 0·25; P = 0·002) and less frequent distant failure (OR 0·23; P &lt; 0·001), with a greater likelihood of being alive (OR 3·28; P = 0·001) and disease-free (OR 4·33, P &lt; 0·001) at 5 years.

Conclusion
A pCR following neoadjuvant CRT is associated with excellent long-term survival, with low rates of local recurrence and distant failure.
Kinetic Study of Epoxy Resin Decomposition in Near‐Critical Water
Authors: Liu Y. Y. , Wei H. , Wu S. , Guo Z. 
Published: February 2012

AbstractA diglycidyl ether type epoxy resin from bisphenol A, E‐51, was cured by methylhexahydrophthalic anhydride (MeHHPA) and then decomposed in near‐critical water without any additives. The effects of the experimental parameters such as the reaction temperature, reaction time, pressure, and feedstock ratio on the percentage of decomposition were investigated to obtain optimized reaction conditions. The results revealed that the percentage of decomposition can be enhanced by increasing either temperature or reaction time. At 260 °C, it initially increased with higher pressure and then decreased dramatically when the pressure further was reduced to the saturated water vapor pressure. The kinetics study of the epoxy decomposition was also carried out by monitoring the glass transition temperature of the solid product using differential scanning calorimetry. The decomposition equation was established and the activation energy was calculated to be 123.5 kJ mol–1.
Beckmann Rearrangement of Cyclohexanone Oxime to ϵ‐Caprolactam in a Microreactor
Authors: Zuidhof N. T. , de Croon M. H. J. M. , Schouten J. C. , Tinge J. T. 
Published: February 2012

AbstractThe selectivity and conversion of the sulfuric acid‐catalyzed Beckmann rearrangement of cyclohexanone oxime, dissolved in cyclooctane, to ϵ‐caprolactam are determined in a microreactor for conditions with a high concentration of ϵ‐caprolactam. The microreactor consists of a low‐temperature mixing zone followed by a high‐temperature reaction zone. The mixing is conducted in a split‐and‐recombine micromixer and a microchannel at 65 °C, followed immediately by a second microchannel at 100–127 °C to obtain complete conversion. Under these conditions a selectivity of 99 % is achieved. The residence time of the reactants in the microreactor setup is about 10 s. In literature, a selectivity of about 95 % for the same reaction in a similar setup is reported, but at a uniform temperature of 120–130 °C for mixing and reaction. So, suppressing the reaction during mixing is a major tool to enhance the selectivity to ϵ‐caprolactam.
Multivalent Gold Glycoclusters: High Affinity Molecular Recognition by Bacterial Lectin PA‐IL
Authors: Reynolds Michael , Marradi Marco , Imberty Anne , Penadés Soledad , Pérez Serge 
Published: February 2012

AbstractMultivalent protein‐carbohydrate interactions are involved in the initial stages of many fundamental biological and pathological processes through lectin–carbohydrate binding. The design of high affinity ligands is therefore necessary to study, inhibit and control the processes governed through carbohydrate recognition by their lectin receptors. Carbohydrate‐functionalised gold nanoclusters (glyconanoparticles, GNPs) show promising potential as multivalent tools for studies in fundamental glycobiology research as well as biomedical applications. Here we present the synthesis and characterisation of galactose functionalised GNPs and their effectiveness as binding partners for PA‐IL lectin from Pseudomonas aeruginosa. Interactions were evaluated by hemagglutination inhibition (HIA), surface plasmon resonance (SPR) and isothermal titration calorimetry (ITC) assays. Results show that the gold nanoparticle platform displays a significant cluster glycoside effect for presenting carbohydrate ligands with almost a 3000‐fold increase in binding compared with a monovalent reference probe in free solution. The most effective GNP exhibited a dissociation constant (Kd) of 50 nM per monosaccharide, the most effective ligand of PA‐IL measured to date; another demonstration of the potential of glyco‐nanotechnology towards multivalent tools and potent anti‐adhesives for the prevention of pathogen invasion. The influence of ligand presentation density on their recognition by protein receptors is also demonstrated.
The Structures, Morphologies, and Photophysical Properties of Multiluminescent Layered Lanthanide–Phosphono–Carboxylate Nanoparticles
Authors: Gentili Pier Luigi , Presciutti Federica , Evangelisti Fabio , Costantino Ferdinando 
Published: February 2012

AbstractA new family of layered metal(III)–phosphono–carboxylate nanostructures (M=Y, Eu, Tb, Er, and Yb) was hydrothermally synthesized and their structures and morphologies were characterized by X‐ray powder diffraction and TEM. 4‐[Bis(phosphonomethyl)amino]caproic acid and 4‐ [bis(phosphonomethyl)amino]undecan‐ oic acid, with general formula (H2O3PCH2)2NR (R=C5H10COOH (P2CAPR) and C10H22COOH (P2UND), respectively) were used as building blocks for the preparation of novel layered hybrid materials in which the inorganic layers were composed of MO7 or MO8 polyhedra and PO3C tetrahedra. The interlayer region was occupied by carboxyalkyl chains. These layered compounds were easily dispersed as stable solutions in alkylamine/water upon ultrasonication. These dispersions were constituted of rectangular elongated nanoparticles (NPs), which showed a distribution of sizes ranging from 20–500 nm. These new materials had interesting photophysical properties because they were multiluminescent compounds. These properties gave rise to several emission bands, which were spread over the broad spectroscopic region, from the near‐UV up to the near‐IR regions. Each emission band had a specific lifetime, which ranged from the sub‐ps to the ms scale.
Highly Homogeneous Stereocontrolled Construction of Quaternary Hydroxyesters by Addition of Dimethylzinc to α‐Ketoesters Promoted by Chiral Perhydrobenzoxazines and B(OEt)3
Authors: Infante Rebeca , Nieto Javier , Andrés Celia 
Published: February 2012

AbstractA highly efficient enantioselective addition of Me2Zn to α‐ketoesters, assisted by a chiral perhydro‐1,3‐benzoxazine ligand, is described. This novel catalytic system offers homogeneous elevated enantioselectivities in the preparation of α‐hydroxyesters that bear a quaternary stereocenter, with a minor dependence on electronic and steric effects when aromatic, heteroaromatic, or aliphatic α‐ketoesters are employed. The catalyst can be recovered and reused without loss of activity.
Synthesis and Reactivity of 5,10,15‐Triaryl Doubly N‐Confused Bilanes
Authors: Toganoh Motoki , Gokulnath Sabapathi , Kawabe Yasunori , Furuta Hiroyuki 
Published: February 2012

AbstractA series of 5,10,15‐tris(pentafluorophenyl) doubly N‐confused bilanes were synthesized in a stepwise manner with the aid of sterically demanding N‐protecting groups, in which the difference in reactivity between regular pyrrole and N‐confused pyrrole plays a crucial role in the synthetic strategy. Some doubly N‐confused bilanes were converted into porphyrinoids or a unique 2:2 copper(II) complex with a helical structure. In addition, the conformations and electronic states of the doubly N‐confused bilanes were investigated theoretically, giving fruitful information about the effect of confusion on the bilane skeleton.
Do Carbenes Have a “Hidden” Carbon(0) Character? Revisiting the Electronic Structure of 2,2′‐Bipyridyl Carbene
Authors: Guha Ankur Kanti , Phukan Ashwini K. 
Published: February 2012

AbstractDensity functional calculations predict that 2,2′‐bipyridyl carbenes have some degree of “hidden” carbon(0) character. This is supported by very high second proton affinity values and bond dissociation energies (BDEs) for the dissociation of one AuCl and one Ni(CO)2 molecule from [(AuCl)2(2,2′‐bipyridyl carbene)] and [{Ni(CO)2}2(2,2′‐bipyridyl carbene)]. An Arduengo type carbene also showed significant BDE values for gem‐dimetallation, thus indicating the possible existence of carbon(0) character. All of the dimetallated derivatives showed metallophilic interactions.
A Smart Gelator as a Chemosensor: Application to Integrated Logic Gates in Solution, Gel, and Film
Authors: Xue Pengchong , Lu Ran , Jia Junhui , Takafuji Makoto , Ihara Hirotaka 
Published: February 2012

AbstractA gelator that consisted of one benzimidazole moiety and four amide units was used as a chemosensor. We found that its absorption and emission spectra in solution were sensitive to two complementary chemical stimuli: protons and anions. Thus, YES and INH logic gates were obtained when absorbance was defined as an output. A combination gate of XNOR and AND with an emission output was also obtained. Moreover, wet gels in two solvents were used to construct two more‐complicated three‐input‐three‐output gates, owing to the existence of the gel phase as an additional output. Finally, in xerogel films that were formed from two kinds of wet gels, reversible changes in their emission spectra were observed when they were sequentially exposed to volatile acid and NH3. Another combination two‐output logic gate was obtained for xerogel films. Finally, three states of the gelator were used to construct not only basic logic gate, but also some combination gates because of their response to multiple chemical stimuli and their multiple output signals, in which one chemical input could erase the effect of another chemical input.
One‐Step Solvothermal Synthesis of Single‐Crystalline TiOF2 Nanotubes with High Lithium‐Ion Battery Performance
Authors: Zeng Yi , Zhang Wenyu , Xu Chen , Xiao Ni , Huang Yizhong , Y. W. Yu Denis , Hng Huey Hoon , Yan Qingyu 
Published: February 2012

AbstractSingle‐crystalline TiOF2 nanotubes were prepared by a one‐step solvothermal method. The nanotubes are rectangular in shape with a length of 2–3 μm, width of 200–300 nm, and wall thickness of 40–60 nm. The formation of TiOF2 nanotubes is directly driven by the interaction between TiF4 and oleic acid in octadecane to form the 1D nanorods, and this is followed by a mass diffusion process to form the hollow structures. The synthesis approach can be extended to grow TiOF2 nanoparticles and nanorods. Compared with TiO2, which is the more commonly considered anode material in lithium‐ion batteries, TiOF2 has the advantages of a lower Li‐intercalation voltage (e.g., to help increase the total voltage of the battery cell) and higher specific capacities. The TiOF2 nanotubes showed good Li‐storage properties with high specific capacities, stable cyclabilities, and good rate capabilities.
ChemInform Abstract: Synthesis, Structural Characterization and Optical Properties of a New Cesium Aluminum Borate, Cs2Al2B2O7.
Authors: Feng Kai , Yin Wenlong , Yao Jiyong , Wu Yicheng 
Published: February 2012

AbstractThe new title compound is prepared by solid state reaction of Cs2CO3, Al2O3, and H3BO3 (1000 °C).
ChemInform Abstract: Li NMR Spectroscopy on Crystalline Li12Si7: Experimental Evidence for the Aromaticity of the Planar Cyclopentadienyl‐Analogous Si56‐ Rings.
Authors: Kuhn Alexander , Sreeraj Puravankara , Poettgen Rainer , Wiemhoefer Hans‐Dieter , Wilkening Martin , Heitjans Paul 
Published: February 2012

AbstractThe Li MAS NMR spectrum of the Zintl phase Li12Si7 shows a distinct signal at ‐17.2 ppm, which can be unambigously assigned to the Li ions sandwiched between cyclopentadienyl‐analogous Si56‐ rings.
ChemInform Abstract: Synthesis and Photocatalytic Activity of Rhodium‐Doped Calcium Niobate Nanosheets for Hydrogen Production from a Water/Methanol System Without Cocatalyst Loading.
Authors: Okamoto Yohei , Ida Shintaro , Hyodo Junji , Hagiwara Hidehisa , Ishihara Tatsumi 
Published: February 2012

AbstractRhodium‐doped calcium niobate nanosheets are obtained by exfoliation of layered KCa2Nb3‐xRhxO10‐δ (x = 0—0.15).
ChemInform Abstract: Lanthanide Complexes of Macrocyclic Polyoxovanadates by VO4 Units: Synthesis, Characterization, and Structure Elucidation by X‐Ray Crystallography and EXAFS Spectroscopy.
Authors: Nishio Masaki , Inami Shinnosuke , Katayama Misaki , Ozutsumi Kazuhiko , Hayashi Yoshihito 
Published: February 2012

AbstractThe title compounds are characterized by single crystal XRD, IR, and EXAFS.
ChemInform Abstract: An Enantioselective, Intermolecular α‐Arylation of Ester Enolates to Form Tertiary Stereocenters.
Authors: Huang Zhiyan , Liu Zheng , Zhou Jianrong 
Published: February 2012

AbstractPalladium catalysts supported by a new chiral H8‐BINOL‐derived monophosphine PHO are applied to the title reaction of enolates (I) with aryl triflates to give the arylated esters with up to 96% enantioselectivity.
ChemInform Abstract: Asymmetric Copper(II)‐Catalyzed Nitroaldol (Henry) Reactions Utilizing a Chiral C1‐Symmetric Dinitrogen Ligand.
Authors: Zhou Yirong , Gong Yuefa 
Published: February 2012

AbstractBoth aromatic and aliphatic aldehydes are converted to nitroalcohol products with up to 96% enantioselectivity in the presence of a copper(II)/exo‐bornylamine derived catalyst.
ChemInform Abstract: Palladium‐Catalyzed Carbohalogenation: Bromide to Iodide Exchange and Domino Processes.
Authors: Newman Stephen G. , Howell Jennifer K. , Nicolaus Norman , Lautens Mark 
Published: February 2012

AbstractAryl bromides of type (I) or (III) undergo a bromide exchange‐induced carboiodination in the presence of KF to give a variety of iodomethyl‐substituted oxygen‐ and nitrogen heterocycles.
ChemInform Abstract: Lead(IV) Acetate Mediated Cleavage of β‐Hydroxy Ethers: Enantioselective Synthesis of α‐Acetoxy Carbonyl Compounds.
Authors: Alvarez‐Manzaneda Enrique , Chahboun Rachid , Alvarez Esteban , Alvarez‐Manzaneda Ramon , Munoz Pedro E. , Jimenez Fermin , Bouanou Hanane 
Published: February 2012

AbstractThe synthesis of a variety of α‐acetoxy carbonyl compounds is efficiently achieved by lead tetraacetate mediated oxidative ring opening of various 2,3‐epoxy primary alcohols.
ChemInform Abstract: Synthesis of (‐)‐Oseltamivir by Using a Microreactor in the Curtius Rearrangement.
Authors: Ishikawa Hayato , Bondzic Bojan P. , Hayashi Yujiro 
Published: February 2012

AbstractThe method avoids the isolation of the potentially hazardous azide intermediate and can be scaled up as an industrial process.
ChemInform Abstract: SiO2‐Supported RuCl3/3‐(Dichloroiodo)benzoic Acid: Green Catalytic System for the Oxidation of Alcohols and Sulfides in Water.
Authors: Zeng Xiao‐Mei , Chen Jiang‐Min , Yoshimura Akira , Middleton Kyle , Zhdankin Viktor V. 
Published: February 2012

AbstractA new green catalytic oxidative system based on SiO2‐supported RuCl3 and 3‐(dichloroiodo)benzoic acid as oxidant is used for the oxidation of alcohols and sulfides under mild conditions in water.
ChemInform Abstract: Active Cobalt Catalyst for the Cleavage of Benzyl Ether.
Authors: Wang Bo , Yin Zhaojun , Li Yangbing , Yang Ting‐Xiang , Meng Xiang‐Bao , Li Zhong‐Jun 
Published: February 2012

AbstractAn improved method for the cleavage of primary and secondary benzyl ethers is reported.
ChemInform Abstract: Iodide‐Catalyzed Reductions: Development of a Synthesis of Phenylacetic Acids.
Authors: Milne Jacqueline E. , Storz Thomas , Colyer John T. , Thiel Oliver R. , Dilmeghani Seran Mina , Larsen Robert D. , Murry Jerry A. 
Published: February 2012

AbstractTreatment of mandelic and phenylglyoxylic acids with NaI/H3PO4/MesOH allows a new and efficient access to phenylacetic acids.
ChemInform Abstract: Ru‐Catalyzed Asymmetric Hydrogenation of γ‐Heteroatom Substituted β‐Keto Esters.
Authors: Fan Weizheng , Li Wanfang , Ma Xin , Tao Xiaoming , Li Xiaoming , Yao Ying , Xie Xiaomin , Zhang Zhaoguo 
Published: February 2012

AbstractThe phosphine efficiently promotes the reduction of a wide range of γ‐heteroatom substituted β‐keto esters.
ChemInform Abstract: Palladium‐Catalyzed Oxidative Carbocyclization/Arylation of Enallenes.
Authors: Jiang Tuo , Persson Andreas K. Aa. , Baeckvall Jan‐E. 
Published: February 2012

AbstractThe reaction is applied to electron‐donating and electron‐withdrawing arylboronic acids tolerating halogens, silyl‐, formyl‐, vinyl‐ and hydroxy‐groups [cf.
ChemInform Abstract: Polystyrene‐Supported Diarylprolinol Ethers as Highly Efficient Organocatalysts for Michael‐Type Reactions.
Authors: Alza Esther , Sayalero Sonia , Kasaplar Pinar , Almasi Diana , Pericas Miquel A. 
Published: February 2012

AbstractThe novel catalyst (I) is effective in additions of aldehydes to nitroolefins and of nitromethane or malonates to α,β‐saturated aldehydes.
ChemInform Abstract: Highly Enantioselective Rhodium‐Catalyzed Asymmetric 1,4‐Addition Reactions of Arylboronic Acids to Acyclic α,β‐Unsaturated Compounds: The Formal Synthesis of (‐)‐Indatraline.
Authors: Wei Wei‐Ting , Yeh Jiann‐Yih , Kuo Ting‐Shen , Wu Hsyueh‐Liang 
Published: February 2012

AbstractChiral 2,5‐disubstituted bicyclo[2.2.1]heptadiene ligands are prepared and applied to the conjugate addition reaction of arylboronic acids to acyclic α,β‐unsaturated compounds.
ChemInform Abstract: Synthesis of α‐CF3‐Substituted Carbonyl Compounds with Relative and Absolute Stereocontrol Using Electrophilic CF3‐Transfer Reagents.
Authors: Matousek Vaclav , Togni Antonio , Bizet Vincent , Cahard Dominique 
Published: February 2012

AbstractThe reaction of lithium imide enolates, generated from ketones, bearing a chiral auxiliary, with hypervalent iodine‐CF3 reagent (II) results in formation of α‐trifluoromethylated products with high diastereoselectivity.
ChemInform Abstract: Efficient and Substrate‐Specific Hydration of Nitriles to Amides in Water by Using a CeO2 Catalyst.
Authors: Tamura Masazumi , Wakasugi Hiroko , Shimizu Ken‐ichi , Satsuma Atsushi 
Published: February 2012

AbstractThe method requires a heteroatom adjacent to the α‐carbon of the CN group.
ChemInform Abstract: Photochemically Induced Radical Transformation of C(sp3)—H Bonds to C(sp3)—CN Bonds.
Authors: Kamijo Shin , Hoshikawa Tamaki , Inoue Masayuki 
Published: February 2012

AbstractActivation of the C—H bonds by photoexcited benzophenone and their cyanation proceeds with complete stereo‐ and chemoselectivity at the most electron‐rich C—H bond.
ChemInform Abstract: Broensted Acid Catalyzed α‐Alkylation of Aldehydes with Diaryl Methyl Alcohols.
Authors: Xing Chong , Sun Hui , Zhang Junmin , Li Guohui , Chi Yonggui Robin 
Published: February 2012

AbstractThe α‐alkylation of aldehydes with diarylmethanols is achieved in the presence of Broensted acids such as TfOH, TosOH or dinitrobenzenesulfonic acid.
ChemInform Abstract: Well‐Defined [Rh(NHC)(OH)] Complexes Enabling the Conjugate Addition of Arylboronic Acids to α,β‐Unsaturated Ketones.
Authors: Truscott Byron J. , Fortman George C. , Slawin Alexandra M. Z. , Nolan Steven P. 
Published: February 2012

AbstractThree stable, monomeric rhodium(I) hydroxide complexes incorporating N‐heterocyclic carbene ligands are synthesized.
ChemInform Abstract: Multicomponent Catalytic Asymmetric Aziridination of Aldehydes.
Authors: Gupta Anil K. , Mukherjee Munmun , Wulff William D. 
Published: February 2012

AbstractVarious aziridine‐2‐carboxylic esters are prepared with high yields and enantioselectivities from imines, generated in situ from aldehydes and the amine (I), with ethyl diazoacetate (EDA).
ChemInform Abstract: Water‐Promoted, Silver—Phosphine Complex‐Catalyzed Stereoselective Cyclization of 2‐(1‐Hydroxy‐3‐arylprop‐2‐ynyl)phenols Leading to a Highly Efficient Approach to Aurones.
Authors: Lin Mingdeng , Yu Min , Han Chengyan , Li Chao‐Jun , Yao Xiaoquan 
Published: February 2012

AbstractThe intramolecular cyclization of (I) is efficiently catalyzed by a silver complex.
ChemInform Abstract: Enantioselective and Regioselective Indium(III)‐Catalyzed Addition of Pyrroles to Isatins.
Authors: Gutierrez Elisa G. , Wong Casey J. , Sahin Aziza H. , Franz Annaliese K. 
Published: February 2012

AbstractThe reaction requires an excess of pyrrole to provide the addition products with high yields and enantioselectivities.
ChemInform Abstract: Ecofriendly and Sustainable Efficient Synthesis of Bis(indolyl)methanes Based on Recyclable Broensted (CSA) or Lewis (ZrOCl2·8H2O) Acid Catalysts.
Authors: Mishra Sarita , Ghosh Rina 
Published: February 2012

AbstractGreen conditions of the reaction, moisture stability and recyclability of the catalyst as well as low toxicity make the present procedure very attractive for its further ramification towards large scale production.
ChemInform Abstract: Rh(III)‐Catalyzed Oxidative Olefination of N‐(1‐Naphthyl)sulfonamides Using Activated and Unactivated Alkenes.
Authors: Li Xuting , Gong Xue , Zhao Miao , Song Guoyong , Deng Jian , Li Xingwei 
Published: February 2012

AbstractActivated olefins react to afford five‐membered azacycles [cf.
ChemInform Abstract: Silica Gel‐Mediated Microwave‐Assisted Efficient Synthesis of Highly Substituted Imidazoles and Exploration of Naked Eye/Colorimetric Sensor for Anions.
Authors: Bhattacharyya Pranabes , Medda Arunima , Samanta Anuva , Guchhait Nikhil , Das Asish R. 
Published: February 2012

AbstractAn improved and very rapid one‐pot synthesis of tri‐ and tetrasubstituted imidazoles via multicomponent cyclocondensation reactions is developed.
ChemInform Abstract: Synthesis and Biological Activities Evaluation of New 4‐(2,4‐Difluorophenyl)‐N‐aryl‐5‐(1H‐1,2,4‐triazol‐1‐yl)thiazol‐2‐amine.
Authors: Liu Jian‐Bing , Dai Hong , Fang Jian‐Xin 
Published: February 2012

AbstractFiveteen thiazole derivatives of type (IV) and (VII) are prepared and tested for their antifungal and plant‐growth regulatory activities.
ChemInform Abstract: Selective Formation of Six‐Membered Oxa‐ and Carbocycles by the In(III)‐Activated Ring Closure of Acetylenic Substrates.
Authors: Qiu Wen‐Wei , Surendra Karavadhi , Yin Liang , Corey E. J. 
Published: February 2012

AbstractThe reaction is catalyzed by InI3 and proceeds with complete selectivity to afford the bi‐, tri‐ and tetracyclic products with good yields.
ChemInform Abstract: Catalyzed Selective Direct α‐ and γ‐Alkylation of Aldehydes with Cyclic Benzyl Ethers by Using T+BF‐4 in the Presence of an Inexpensive Organic Acid or Anhydride.
Authors: Richter Heinrich , Rohlmann Renate , Garcia Mancheno Olga 
Published: February 2012

AbstractThe reaction of the cyclic benzyl ethers with various carbonyl compounds as aldehydes, ketones and α,β‐unsaturated aldehydes applies oxoammonium salt TBF as the formal hydrogen acceptor and Cu(OTf)2 as a catalyst.