bluuebunny/crossref_metadata_2025_split huggingface dataset:
Differential Feeding of Fall Armyworm Lepidoptera(Lepidoptera: Noctuidae) Host Strains on Meridic and Natural Diets
Authors: Meagher Robert L , Nagoshi Rodney N 
Published: May 2012

Abstract
Fall armyworm, Spodoptera frugiperda (J.E. Smith) (Lepidoptera: Noctuidae), is composed of two sympatric, morphologically identical host strains (corn and rice) that differ in their distribution on different host plants. This suggests possible strain specificity in the use of host plants. However, although feeding studies published since 1987 have reported such developmental differences, the results were often contradictory, making generalizations about strain-specific physiological traits problematic. Here, we tested whether more consistent results could be obtained using several genetically characterized colonies when assayed in the same laboratory. We also assessed whether a commonly used meridic diet was more favorable to one strain and the potential this might have on altering the behavior of artificially raised colonies. Corn and rice strain colonies were characterized by cytochrome oxidase I (COI) strain markers and were subjected to feeding studies using corn (Zea mays L.), stargrass (Cynodon nlemfuensis Vanderyst variety nlemfuensis ‘Florona’), and a meridic pinto bean diet. In 2005 bioassays, all colonies developed best on corn, whereas the meridic and stargrass diets were associated with more pronounced strain differences. However, bioassays conducted in 2010 using different colonies showed fewer differences between host strains. The limitations of feeding bioassays and the COI marker to identify host strains and the potential for unintended selection of corn strain traits when using a meridic diet are discussed.
Spermatophore Size in Relation to Body Size and Pairing Duration in Northern Corn Rootworm (Coleoptera: Chrysomelidae)
Authors: French B Wade , Hammack Leslie 
Published: May 2012

Abstract
Female insects may choose to mate with males providing the largest nuptial gift via the spermatophore, which may correlate with fitness related characters such as body size. Here, we examined spermatophore size of northern corn rootworm, Diabrotica barberi Smith & Lawrence (Coleoptera: Chrysomelidae), in relation to body size of males and females and in relation to pairing duration. Virgin males and females of known ages were weighed before and after pairing. Pairs were noted as copulating or not copulating. Copulating males lost significantly more weight than did noncopulating males, whereas copulating females gained significantly more weight than did noncopulating females. For copulating pairs, male and female weight before pairing correlated positively. Spermatophore weight correlated positively with male weight before pairing and was estimated to be 0.37 or 0.38 mg, depending on whether weight change data from males or females were used for estimation. Spermatophore mass accounted for ≈4.4% of male body weight. An effect of pairing duration on spermatophore weight was demonstrable only when weight change data from females were used. Implications of the results for management of rootworm resistance to genetically modified maize are discussed.
Association of HER-2 Copy Number and HER-2/CEP-17 Ratio with Neoadjuvant Taxane-Containing Chemotherapy Sensitivity in Locally Advanced Breast Cancer
Authors: Yu Ke-Da , Liu Guang-Yu , Zhou Xiao-Yan , Zhou Ying , Wu Jiong , Chen Can-Ming , Shen Zhen-Zhou , Shao Zhi-Ming 
Published: May 2012

Abstract

Learning Objectives
After completing this course, the reader will be able to:Compare the clinical value of copy number–based fluorescence in situ hybridization (FISH) versus HER-2/CEP-17 ratio-based FISH in identifying patients who may benefit from taxane-containing neoadjuvant chemotherapy.Consider the implications of HER-2 copy number and aneusomy 17 when making treatment decisions in patients with locally advanced breast cancer.
CME This article is available for continuing medical education credit at CME.TheOncologist.com

Purpose.
Aneusomy 17 causes inconsistency in fluorescence in situ hybridization (FISH)-based human epidermal growth factor receptor (HER)-2 status assessment using different algorithms (copy number or the HER-2/centromere enumerator probe 17 [CEP-17] ratio). We investigated the effects of FISH-based HER-2 status assessment and aneusomy 17 on responsiveness to neoadjuvant chemotherapy (NAC).

Patients and Methods.
This prospective study recruited 152 patients with locally advanced breast cancer who underwent four-cycle weekly paclitaxel plus carboplatin without trastuzumab.

Results.
The pathologic complete remission (pCR) rate in the breast and axilla was 24.3% (95% confidence interval [CI], 17.7%–32.0%). Although HER-2 status, assessed by either HER-2/CEP-17 ratio–based FISH or copy number–based FISH, was a predictor of NAC sensitivity, ratio–assessed HER-2 status had a poorer performance in determining patients' responsiveness to NAC (p = .029). Patients who were not HER-2 amplified when assessed using the HER-2/CEP-17 ratio but were HER-2 amplified when assessed using copy number (∼5%) were eventually proven to be responsive to NAC, with a pCR rate of 57% (95% CI, 18.4%–90.1%). In contrast, patients who were HER-2 amplified when assessed by the ratio but not HER-2 amplified when assessed using copy number (∼3%) were completely irresponsive. Higher HER-2 copy numbers represented increasing chances of a pCR (adjusted odds ratio, 3.09; 95% CI, 1.35–7.08), with an apparent gene–dose effect (p for trend &lt; .001).

Conclusion.
It is likely that HER-2 copy number but not the HER-2/CEP-17 ratio determines NAC sensitivity. Additional studies to validate our findings are warranted.
European Perspective on Multiple Myeloma Treatment Strategies: Update Following Recent Congresses
Authors: Ludwig Heinz , Avet-Loiseau Hervé , Bladé Joan , Boccadoro Mario , Cavenagh Jamie , Cavo Michele , Davies Faith , Rubia Javier , Delimpasi Sosana , Dimopoulos Meletios , Drach Johannes , Einsele Hermann , Facon Thierry , Goldschmidt Hartmut , Hess Urs , Mellqvist Ulf-Henrik , Moreau Philippe , San-Miguel Jesús , Sondergeld Pia , Sonneveld Pieter , Udvardy Miklos , Palumbo Antonio 
Published: May 2012

Abstract
The management of multiple myeloma has undergone profound changes over the recent past as a result of advances in our understanding of the disease biology as well as improvements in treatment and supportive care strategies. Notably, recent years have seen a surge in studies incorporating the novel agents thalidomide, bortezomib, and lenalidomide into treatment for different disease stages and across different patient groups. This article presents an update to a previous review of European treatment practices and is based on discussions during an expert meeting that was convened to review novel agent data published or presented at medical meetings until the end of 2011 and to assess their impact on treatment strategies.
Seasonal waves of influenza and cause-specific mortality in Germany
Authors: Huy Christina , Kuhn Dorothee , Schneider Sven , Zöllner Iris 
Published: May 2012

Abstract
Seasonal influenza epidemics regularly lead to an increase in population-based mortality in Germany and other industrialized nations. This study aimed to investigate seasonal variations in waves of influenza and cause-specific mortality rates. We analyzed influenza case data, monthly mortality rates and environmental temperature in the state of Baden-Wuerttemberg, Germany, between 2001 and 2006 using visual methods and bivariate statistics. Peaks in overall mortality rates were associated with waves of influenza and preceded by a drop in the environmental temperature. During an influenza epidemic, many cause-specific mortality rates increased, that is to say, there were coinciding peaks for diseases of the respiratory and the circulatory system. There are several reasons which might explain the observed temporal associations between reported cases of influenza and cause-specific mortality: 1) the general physical impairment of persons with chronic diseases; 2) the combined effect of low environmental temperatures and seasonal waves of influenza; 3) the system of coding underlying disease in death certificates. Our findings point to an underestimated role of influenza in mortality in Germany.
Unsteady transonic aerodynamics during wing flutter
Authors: Saitoh Kenichi , Tamayama Masato , Yoshimoto Norio , Ueda Tetsuhiko 
Published: May 2012

Abstract
Unsteady pressure distributions of a two-dimensional super-critical wing while it was fluttering were measured in the transonic flow regime. The results were compared with those by the Navier-Stokes code which includes wind-tunnel wall effects. Although there were discrepancies between the experimental results and the analytical model for the pressure phase delay distribution, no disagreements were observed for the pitching first harmonics provided that there was no large flow separation. In the tests, the flutter was forced to be suppressed soon after its onset before it reached a limit cycle oscillation (LCO) where the amplitude of the pitching angle was supposed to be over 2 degrees.
Immunotherapy of cancer in 2012
Authors: Kirkwood John M. , Butterfield Lisa H. , Tarhini Ahmad A. , Zarour Hassane , Kalinski Pawel , Ferrone Soldano 
Published: May 2012

AbstractThe immunotherapy of cancer has made significant strides in the past few years due to improved understanding of the underlying principles of tumor biology and immunology. These principles have been critical in the development of immunotherapy in the laboratory and in the implementation of immunotherapy in the clinic. This improved understanding of immunotherapy, enhanced by increased insights into the mechanism of tumor immune response and its evasion by tumors, now permits manipulation of this interaction and elucidates the therapeutic role of immunity in cancer. Also important, this improved understanding of immunotherapy and the mechanisms underlying immunity in cancer has fueled an expanding array of new therapeutic agents for a variety of cancers. Pegylated interferon‐α2b as an adjuvant therapy and ipilimumab as therapy for advanced disease, both of which were approved by the United States Food and Drug Administration for melanoma in March 2011, are 2 prime examples of how an increased understanding of the principles of tumor biology and immunology have been translated successfully from the laboratory to the clinical setting. Principles that guide the development and application of immunotherapy include antibodies, cytokines, vaccines, and cellular therapies. The identification and further elucidation of the role of immunotherapy in different tumor types, and the development of strategies for combining immunotherapy with cytotoxic and molecularly targeted agents for future multimodal therapy for cancer will enable even greater progress and ultimately lead to improved outcomes for patients receiving cancer immunotherapy. CA Cancer J Clin 2012. © 2012 American Cancer Society.
Child Psychiatric Disorders Presenting to a Tertiary Multidisciplinary Child Development Service in Bangladesh
Authors: Islam Farzana , Parveen Monowara , Parvin Rezina , Begum Dilara , Muslima Humaira , Khatun Mahmuda , Mahbub Mustafa , Khan Naila Zaman 
Published: May 2012

Background: Shishu Bikash Kendra (SBK or Child Development Center) of the Dhaka Shishu (Childrens) Hospital (DSH) has been using a multidisciplinary approach for assessment and management of children with various neurodevelopmental disorders since its establishment in 1991. In the past decade, a major proportion have presented with a range of emotional and behavioural problems. This paper aims to describe the types of child psychiatric disorders and the multidisciplinary team approach used in this centre for diagnosis and management of these children.Patients and Methods: Clinical records of 300 children who were assessed by the Child Mental Health Clinic of SBK during April 2004 to December 2006 were analyzed. These children were among the 1648 children who were referred for behavioural problems after having a General Developmental assessment (GDA). Children received services by a team comprising of child health physicians, child neurologists, child psychologists, developmental therapists and psychosocial counselors and a social worker. Psychiatric conditions were diagnosed using the multi-axial diagnostic guidelines of the Diagnostic and Statistical Manual (DSM-IV) and the International Classification of Diseases (ICD-10). The role of various clinics of the SBK to address specific aspects of a childs mental health condition is described.Results: Of the 300 children seen 55% were of primary school age (ie, between 5-10 years), boys comprising 71%. The majority (94%) could be categorized into a psychiatric condition. Sixty three percent had a developmental problem. In addition, with 44% children having some intellectual deficit. Sixty one percent had an associated neurological or general medical condition. It was important to note also that 54% had some form of psychosocial adversity which needed immediate help. Commonest psychiatric diagnosis was Hyperkinetic Disorders (33%) followed by Autism Spectrum Disorders (ASD) and other Pervasive Developmental Disorders (PDD) (27%).Conclusion: Psychiatric morbidity is a common presentation among children who come to the child development and neurodisability service. If Child Mental Health professionals work with a multidisciplinary team within a child development service such as SBK, it may best utilize the multiaxial diagnosis system.DOI: http://dx.doi.org/10.3329/bjch.v35i3.10385 Bangladesh J Child Health 2011; Vol 35 (3): 84-89
La création sans créateur : le cas de Maison Martin Margiela
Authors: Pungetti Giovanni , Caputo Stefano 
Published: May 2012

Résumé Martin Margiela a surpris en décidant de se retirer sans nommer de nouveau directeur créatif. Comment est-ce possible quand d’ordinaire une maison de mode est portée par un créateur emblématique ? Deux ans après ce choix osé, l’histoire de la maison peut redébuter...
Entrepreneurs et capitalistes chinois : qui sont-ils ?
Authors: Chevrier Yves 
Published: May 2012

Résumé Le nouveau capitalisme chinois est-il capitaliste ? On l’a dit confucianiste, on découvre qu’il est étatiste. À distance des clichés identitaires et des catégories a priori, une analyse sociologique et historique décrypte ces paradoxes.
Des décisions absurdes aux processus de la haute fiabilité
Authors: Morel Christian , Oury Jean-Marc 
Published: May 2012

Résumé Après Les décisions absurdes, Christian Morel s’est tourné vers les univers à risques. Il remet en cause les “ bons principes” du management et énonce des métarègles contribuant à des décisions hautement fiables. Peut-on les transposer à la gestion d’entreprise ?
Le besoin de santé organisationnelle dans les établissements de soins : l'impact du care collectif
Authors: Beaucourt Christel , Louart Pierre 
Published: May 2012

Résumé La santé d’un collectif soignant, ses relations et son organisation ont des conséquences directes sur la qualité du travail dans les établissements de soins. Des soignants qui se sentent déconsidérés ou épuisés sont susceptibles de « décharger » leurs tensions, en les projetant ou en les déplaçant sur ceux auxquels ils sont censés venir en aide. A l’inverse, un partage collectif de sens, des soutiens relationnels et des marges de manœuvre organisationnelles aident le collectif soignant à prendre en charge ses missions en les adaptant au mieux aux besoins rencontrés. Cette interprétation dynamique et coopérative de l’action collective peut être analysée en termes de care collectif, selon des dimensions cognitives, relationnelles et managériales. C’est ce qu’expose l’article, en illustrant une première approche théorique par des récits de pratiques réalisés par les acteurs eux-mêmes. La théorisation et les exemples mettent en avant certaines conditions managériales pour qu’émerge et se développe un dispositif de care collectif.
Le management de proximité des services relationnels : entre management par les résultats et place laissée au bricolage et à l'expression du désir
Authors: Chemin-Bouzir Carine 
Published: May 2012

Résumé Dans le cas de l’aide à domicile, différents types de « services relationnels » sont identifiés. On observe que le management de proximité a un rôle de management par les résultats en fixant des objectifs dans le cas de services à visée éducative, et qu’il pose des limites et régule les conflits quand on souhaite que l’intervenante soit « le rayon de soleil » de la personne aidée.
Conditions et limites d'une démarche de prospective métier dans un secteur de PME touché par la crise économique
Authors: Remy Céline , Pichault François 
Published: May 2012

Résumé Cet article vise à rendre compte de la difficulté de mener un exercice prospectif dans un secteur composé de petites entreprises et touché par une crise économique. Il se structure en trois parties : la première consiste en la mise en perspective des controverses du champ de la méthode prospective. La deuxième partie se dédie à une étude de cas pour laquelle nous avons recouru à la méthode prospective dans un secteur d’activité regroupant fabrications métalliques et industrie technologique. La troisième partie discute des différents aspects méthodologiques issus de l’intervention et tire des enseignements.
Comment les consommateurs choisissent-ils leurs romans ? Proposition d'une typologie des processus décisionnels et étude des variables d'influence
Authors: Baillet Caroline , Berge Orélien 
Published: May 2012

Résumé L’étude de l’achat d’un roman nous permet d’analyser un nombre conséquent de variables propres à la triade consommateur-produit-situation et de tester leur influence sur les modes de sélection d’un bien. Nous proposons par ailleurs une typologie des processus décisionnels renvoyant à différents phénomènes de consommation : procrastination, fidélité, inertie, butinage, recherches préachats, mécanismes mentaux de prise de décision, influence du packaging.
Boosting territorial multi-stakeholder cooperation, coordination and collaboration: strategic and managerial issues
Authors: Michaux Valéry , Defélix Christian , Raulet-Croset Nathalie 
Published: May 2012

Résumé Cet article introduit un cahier spécial de la revue Management &Avenir sur un sujet nouveau. Notre objet de recherche n’est pas ici le territoire en tant que construction historique identitaire et socio-économique générant des externalités positives, un point de vue bien circonscrit par les champs de l’économie et de la géographie. Il n’est pas non plus celui de l’émergence quasi-spontanée de formes de coordination, sans l’impulsion d’un acteur moteur. Nous nous intéressons ici aux démarches, impulsées par les acteurs locaux eux-mêmes ou par les pouvoirs publics pour développer une meilleure coopération, coordination et collaboration locale. Or, si la recherche s’est longtemps intéressée aux difficultés de mise en place de tels multipartenariats, elle s’est finalement moins intéressée au volet managérial de ces démarches territoriales. Quelles sont les problématiques managériales et stratégiques sous-jacentes à l’impulsion de coopération, de coordination et/ou de collaboration sur un territoire donné ?
Les stratégies collectives sont-elles toujours applicables dans un « milieu » ? Une réflexion à partir du contre exemple de la coutellerie thiernoise
Authors: Asselineau Alexandre , Cromarias Anne 
Published: May 2012

Résumé L’existence d’un contexte de type « milieu innovateur », la taille réduite des entreprises et un déclin industriel local incitent souvent les institutionnels à initier des stratégies collectives entre entreprises d’un même secteur. Cette option est-elle systématiquement envisageable ? L’exemple des couteliers de Thiers montre que, si nous sommes en présence simultanée d’intérêts économiques proches et d’une proximité géographique, les dimensions cognitive, organisationnelle et d’apprentissage du milieu se heurtent au caractère entrepreneurial de celui-ci, créant une forte résistance à la mise en place d’une stratégie collective.
La personnalité de l'enseigne : un outil de marketing relationnel
Authors: Lombart Cindy , Louis Didier 
Published: May 2012

Résumé Cette recherche propose un modèle intégrateur des conséquences relationnelles de la personnalité de l’enseigne. Sept traits de personnalité (sur neuf au total) de l’enseigne étudiée, la Fnac, influencent directement, positivement ou négativement, au moins l’une des conséquences relationnelles considérées : la confiance, l’attachement, l’engagement affectif et l’engagement de continuation. Ils ont de plus une influence indirecte sur l’engagement affectif et l’engagement de continuation via la confiance et l’attachement. Cette recherche souligne ainsi l’intérêt managérial du concept de personnalité de l’enseigne. Ce concept peut aider les distributeurs à gérer leur marque-enseigne et à créer, maintenir et renforcer la relation avec leurs clients.
La spécificité du commerce BtoB : quelques repères historiques
Authors: Michel Sophie , Pardo Catherine 
Published: May 2012

Résumé Les intermédiaires du commerce de gros ayant été largement vus comme un choix aux mains des producteurs et fabricants, rares sont les travaux se plaçant du point de vue de cet intermédiaire particulier qu’est le grossiste. Cette absence de focalisation sur l’objet « grossiste » a bien souvent amené à un traitement indifférencié du commerce de gros et du commerce de détail sous l’en-tête générique de la « distribution », avec une importance croissante accordée à la distribution de détail. En a-t-il toujours été de même ? Cet article se propose, en puisant à une littérature plus historienne que gestionnaire, de donner quelques repères historiques (de l’Antiquité à la période actuelle) quant aux distinctions opérées entre commerce de gros et commerce de détail, et à la position de ce commerce de gros dans l’économie, voire, plus généralement, dans la société. Il apparaît alors que, si aujourd’hui le commerce inter-entreprises souffre d’un manque de considération et souvent d’une image négative, il n’en n’a pas toujours été de même.
Les pratiques culturelles des Français à l'ère du numérique, enquête 2008
Authors: Souchon Michel 
Published: May 2012

Resumé Olivier Donnat, Les pratiques culturelles des Français à l’ère du numérique, enquête 2008 , La Découverte/Ministère de la Culture et de la Communication, 2010, 288 p., 20 €