bluuebunny/crossref_metadata_2025_split huggingface dataset:
Developing a Financial Framework for Academic Service Partnerships: Models of the United States and Europe
Authors: De Geest Sabina , Sullivan Marx Eileen M. , Rich Victoria , Spichiger Elisabeth , Schwendimann Rene , Spirig Rebecca , Van Malderen Greet 
Published: July 2010

Abstract Purpose: Academic service partnerships (ASPs) are structured linkages between academe and service which have demonstrated higher levels of innovation. In the absence of descriptions in the literature on financial frameworks to support ASPs, the purpose of this paper is to present the supporting financial frameworks of a Swiss and a U.S. ASP. Methods: This paper used a case study approach. Results: Two frameworks are presented. The U.S. model presented consists of a variety of ASPs, all linked to the School of Nursing of the University of Pennsylvania. The structural integration and governance system is elucidated. Each ASP has its own source of revenue or grant support with the goal to be fiscally in the black. Joint appointments are used as an instrument to realize these ASPs. The Swiss ASP entails a detailed description of the financial framework of one ASP between the Institute of Nursing Science at the University of Basel and the Inselspital Bern University Hospital. Balance in the partnership, in terms of both benefit and cost between both partners, was a main principle that guided the development of the financial framework and the translation of the ASP in budgetary terms. The model builds on a number of assumptions and provides the partnership management within a simple framework for monitoring and evaluation of the progress of the partnership. Conclusions: In operationalizing an ASP, careful budgetary planning should be an integral part of the preparation and evaluation of the collaboration. The proposed Swiss and U.S. financial frameworks allow doing so. Clinical Relevance: Outcomes of care can be improved with strong nursing service and academic partnerships. Sustaining such partnerships requires attention to financial and contractual arrangements.
Neurocognitive dysfunction and psychosocial outcome in patients with bipolar I disorder at 15‐year follow‐up
Authors: Burdick K. E. , Goldberg J. F. , Harrow M. 
Published: July 2010

Burdick KE, Goldberg JF, Harrow M. Neurocognitive dysfunction and psychosocial outcome in patients with bipolar I disorder at 15‐year follow‐up.Objective:  Despite increasing interest in cognitive dysfunction in bipolar disorder, little is known about its impact on functional outcome relative to affective symptoms.Method:  A total of 33 bipolar I subjects were evaluated at index hospitalization and prospectively followed up 15 years later. Affective symptoms, cognition, global functioning, work, and social adjustment were assessed at follow‐up and analyzed by linear regression.Results:  Global functional impairment was significantly associated with poor performance on a cognitive measure of processing speed (WAIS Digit Symbol). Digit symbol performance also was the sole significant predictor of social functioning. Neither symptom severity nor course of illness features significantly contributed to global and social functioning. In contrast, verbal learning deficits, recent depression, and lifetime hospitalizations all were independently associated with work disability.Conclusion:  Processing speed is robustly associated with social and global functioning in bipolar disorder. Poor work functioning is significantly related to subsyndromal depression, course of illness, and verbal learning deficits. Cognitive and mood symptoms warrant consideration as independent determinants of functioning in patients with bipolar disorder many years after an index manic episode.
Extramammary Paget’s diseases in men from the Shanghai area: its association with PSA level increase*
Authors: SHI GUOHAI , YE DING‐WEI , YAO XUDONG , ZHANG SHILING , DAI BO , ZHANG HAILIANG , SHEN YIJUN , ZHU YAO , ZHU YIPING , XIAO WENJUN , MA CHUNGUANG 
Published: July 2010

Shi G, Ye D‐W, Yao X, Zhang S, Dai B, Zhang H, Shen Y, Zhu Y, Zhu Y, Xiao W, Ma C. Extramammary Paget’s diseases in men from the Shanghai area: its association with PSA level increase. APMIS 2010; 118: 777–81.The aim of this study was to determine the incidence of prostate cancer in patients with extramammary Paget’s disease (EMPD). All cases of EMPD diagnosed between 1992 and 2007 in Shanghai Cancer Hospital were collected and analyzed for the incidence of prostate cancer. The median follow‐up was 78 months. In total, 38 cases of invasive and 10 cases of in situ EMPD had been registered. A second malignancy was found in 28.9% (11/38) of patients with invasive EMPD and in 30% (3/10) of patients with in situ EMPD. Patients had an increased risk of developing a second cancer compared with the general population (standardized incidence ratio: 1.7; 95% confidence interval 1.2–2.4). Sixteen patients had serum prostate‐specific antigen (PSA) level above 4 ng/mL; five developed prostate cancer, three of them with PSA levels beyond 100 ng/mL. The incidence of prostate cancer is 10.4% in this patient group. Patients with EMPD were more likely to have prostate cancer than the general population. Although the prognosis of EMPD is fairly good, a thorough search for a second tumor is recommended.
Clinical performance of provisional screw‐retained metal‐free acrylic restorations in an immediate loading implant protocol: a 242 consecutive patients' report
Authors: Suarez‐Feito Jose‐María , Sicilia Alberto , Angulo Jorge , Banerji Subir , Cuesta Isabel , Millar Brian 
Published: July 2010

AbstractObjective: To evaluate the clinical performance of provisional screw‐retained metal‐free acrylic restorations in an immediate loading implant protocol.Material and methods: Two hundred and forty‐two consecutive patients were selected retrospectively, who received 1011 implants and 311 immediate provisional screw‐retained implant restorations (2–4 h after implant surgery). The patients were monitored for a period of 2–3 months, until they were referred for a final restoration. The primary variables recorded include the survival time and the appearance of fractures in the provisional restoration, and the independent variables included age, sex, dental arch, type of restoration, type of attachment and components used, as well as cantilevers and opposing dentition. A survival analysis (Kaplan–Meier) and a Cox regression analysis were performed.Results: Twenty‐three restorations in 20 patients (8.26%, 95% CI 4.8–11.7) showed at least one fracture (7.39%). More than half of the new fractures (52%, 12 cases) occurred in the first 4 weeks. The cumulative survival probability observed was greater in mandible (P=0.05) and non‐cantilever restorations (P=0.001), and in those opposed by full restorations or natural teeth (P=0.001). With an opposing implant‐supported prosthesis, the risk of fracture was multiplied by 4.7, and the use of cantilevers as well as the location of the restoration in the maxilla multiply the risk by 3.4–3.5.Conclusions: Immediate provisional screw‐retained metal‐free implant‐supported restorations can be considered a reliable restoration (92.6% remain intact) for the healing period of 3 months. To cite this article:
Suarez‐Feito JM, Sicilia A, Angulo J, Banerji S, Cuesta I, Millar B. Clinical performance of provisional screw‐retained metal‐free acrylic restorations in an immediate loading implant protocol: a 242 consecutive patients' report. Clin. Oral Impl. Res. 21, 2010; 1360–1369. doi: 10.1111/j.1600‐0501.2010.01956.x
Onlay bone grafting of the mandible after periosteal expansion with an osmotic tissue expander: an experimental study in rabbits
Authors: Abrahamsson Peter , Isaksson Sten , Gordh Monica , Andersson Gunilla 
Published: July 2010

AbstractObjectives: To evaluate the space‐maintaining capacity of a titanium mesh or a bioresorbable mesh after periosteal expansion and to assess bone formation under a titanium mesh or a bioresorbable mesh on the lateral border of the mandible by qualitative and quantitative histological analysis.Material and methods: In 13 rabbits, a self‐inflatable soft tissue expander was placed intraorally, bilaterally under the mandibular periosteum via an extra oral approach. After 2 weeks, the expanders were removed and a particulated onlay bone graft was placed and covered by a titanium mesh or a bioresorbable mesh. After 3 months, the animals were sacrificed and specimens were collected for histology.Results: The osmotic soft tissue expander created a subperiosteal pocket and a ridge of new bone had formed at the edges of the expanded periosteum in all sites. After the healing period of 3 months, soft tissue dehiscence was recorded in two of the sites with bioresorbable meshes. The mean bone fill was 65% under the titanium mesh and 85% under the bioresorbable mesh (P<0.05). There was no significant difference between the titanium mesh and the bioresorbable mesh regarding the height of the meshes, mesh area and mineralized bone area. Scanning electron microscopy shows that new bone is growing in direct contact with the resorbable mesh and the titanium mesh.Conclusion: This study confirms that an osmotic soft tissue expander creates a surplus of periosteum and soft tissue and that new bone can be generated under a titanium mesh or bioresorbable mesh. To cite this article:
Abrahamsson P, Isaksson S, Gordh M, Andersson G. Onlay bone grafting of the mandible after periosteal expansion with an osmotic tissue expander: an experimental study in rabbits. Clin. Oral Impl. Res21, 2010; 1404–1410. doi: 10.1111/j.1600‐0501.2010.01967.x
A simple method for enhancing cell adhesion to hydroxyapatite surface
Authors: Bertazzo Sergio , Zambuzzi Willian F. , Campos Daniela D. P. , Ferreira Carmen V. , Bertran Celso A. 
Published: July 2010

AbstractObjectives: Increase cell adhesion on hydroxyapatite (HA) surface, in a simple, fast and inexpensive way.Material and methods: Hydroxyapatite powder was immersed into deionized water for 15 days, dried and pressed into discs. On those discs, pre‐osteoblasts cells were cultured for 30 min and 24 h, and adhesion was analyzed by MTT reduction.Results: The results show that HA treatment in equilibrium with water drastically increases cell adhesion when compared with cultures on HA with no treatment. The results also show that one essential factor required for a complete modification of HA is the amount of time of immersion in water.Conclusions: The work presented here suggests a new, simple and effective method to improve the success of different implants. The method is simple, inexpensive and can be used in the daily routine of different contexts where implants are used, from bone substitution to dental procedures. To cite this article:
Bertazzo S, Zambuzzi WF, Campos DDP, Ferreira CV, Bertran CA. A simple method for enhancing cell adhesion to hydroxyapatite surface. Clin. Oral Impl. Res. 21, 2010; 1411–1413. doi: 10.1111/j.1600‐0501.2010.01968.x
Developmental monitoring using caregiver reports in a resource‐limited setting: the case of Kilifi, Kenya
Authors: Abubakar A , Holding P , Van de Vijver F , Bomu G , Van Baar A 
Published: July 2010

AbstractAim:  The main aim of the current study was to evaluate the reliability, validity and acceptability of developmental monitoring using caregiver reports among mothers in a rural African setting.Methods:  A structured interview for parents of children aged 24 months and less was developed through both participant consultation and a review of literature. The reliability and validity of the schedule was evaluated through a 10‐month monitoring programme of 95 children, aged 2–10 months. The acceptability of the process was evaluated by studying retention rates and by organizing focus group discussions with participating mothers.Results:  The structured interview ‘Developmental Milestones Checklist’ consisted of 66 items covering three broad domains of child functioning: motor, language and personal–social development. The interview yielded scores of developmental achievements that showed high internal consistency and excellent test–retest reliability. The results were sensitive to maturational changes and nutritional deficiencies. In addition, acceptable retention rates of approximately 80% were found. Participating mothers reported that they found the procedures both acceptable and beneficial.Conclusion:  Developmental monitoring using caregiver report is a viable method to identify and monitor at‐risk children in Sub‐Saharan Africa.
Grounded literacies: the power of listening to, telling and performing community stories
Authors: Hall Christine , Thomson Pat 
Published: July 2010

AbstractThis article offers an analysis of community arts to develop an argument about the power of vernacular literacies. We draw on Paul Willis' work about grounded aesthetics and everyday symbolic creativity in common culture, and Scollon and Scollon's notions of geosemiotics, to analyse a community play written and performed in a council estate in Nottingham, England. In particular, we argue that Scollon and Scollon's idea of the ‘semiotic aggregate’ offers a useful analytical tool for understanding and evaluating the significance of participation, recognition, representation and place in multimodal texts.
Children's advertisement writing
Authors: Burrell Andrew , Beard Roger 
Published: July 2010

AbstractThis paper explores primary school children's ability to engage with “the power of the text” by tackling persuasive writing in the form of an advertisement. It is eclectically framed within genre theory and rhetorical studies and makes use of linguistic tools and concepts. The paper argues that writing research has not built upon earlier publications in these areas. There is a need for studies of advertisement writing to consolidate and extend the recent interest in non‐fiction text types. The writing of two children, drawn from a much larger study, is used to provide evidence of some key features of advertisement writing. Use of a pro forma reveals how children imbue the power of their writing through a variety of techniques and suggests how these features may develop over time. It is argued that an understanding of advertisement writing warrants careful exploration, as persuasive writing is generally being given a more prominent place in curriculum provision in England. The paper concludes by noting the importance of ecological validity and pupil engagement when persuasive writing is tackled in schools. It also suggests the need for new kinds of customised analyses when further studies of this kind of writing are undertaken.
Association between metabolic syndrome and estimated glomerular filtration rate in older Koreans based on data from the third Korean National Health and Nutrition Examination Survey
Authors: Park Yong Soon , Kim Jun‐Su 
Published: July 2010

Aim:  To examine the association between metabolic syndrome (MetS) and renal function in older Koreans.Methods:  A total of 1270 people aged 60 years and older who participated in the third Korean National Health and Nutrition Examination Survey were included in this study.Results:  After adjusting for confounding factors, central obesity, high‐density lipoprotein cholesterol and fasting glucose were significantly associated with decreased renal function in men. In women, however, each component of MetS with the exception of fasting glucose was not associated with renal function. The odds ratios for MetS were 2.548 in men and 1.454 in women after adjustment for confounding variables; both were statistically significant. The odds ratio of decreased renal function increased as the number of components of MetS increased.Conclusion:  The results of this study suggest that MetS may be an independent risk factor for decreased renal function in older population as well.
Apical serine protease activity is necessary for assembly of a high‐resistance renal collecting duct epithelium
Authors: Steensgaard M. , Svenningsen P. , Tinning A. R. , Nielsen T. D. , Jørgensen F. , Kjærsgaard G. , Madsen K. , Jensen B. L. 
Published: July 2010

AbstractAim:  We hypothesized that the serine protease prostasin is necessary for differentiation of a high‐resistance renal collecting duct epithelium governed by glucocorticoid.Methods:  Postnatal rat kidney and adult human kidney was used to study the expression and localization of prostasin. The murine collecting duct cell line (M‐1) was cultured in Snapwell inserts to investigate the significance of prostasin for the development of transepithelial electrical resistance (TER).Results:  In the cortex and medulla of rat kidney, prostasin mRNA and protein increased significantly between birth and weaning (day 21) and was detected in collecting ducts. Immunoreactive prostasin was associated with collecting ducts and loops of Henle in human kidney. In rat, adrenalectomy at day 10 had no effect on prostasin mRNA level in kidney at day 20. Cultured M‐1 cells exhibited parallel increases in prostasin mRNA, protein and TER 5 days after seeding. Apical addition of the serine protease inhibitor aprotinin to M‐1 cell cultures inhibited development of TER and led to aberrant localization of E‐cadherin. This effect was mimicked by the protease inhibitor nafamostat. Apical addition of phospholipase C to cleave glycosylphosphatidylinositol (GPI) anchors released prostasin to the medium and attenuated development of TER with time of culture. Disruption of lipid rafts by methyl‐β‐cyclodextrin attenuated development of TER in M‐1 cells. Omission of dexamethasone impaired development of TER in M‐1 cells, while prostasin protein abundance and E‐cadherin distribution did not change.Conclusion:  Apical, GPI‐anchored, lipid raft‐associated serine protease activity, compatible with prostasin, is necessary for the development of a high‐resistance collecting duct epithelium.
CHEMICAL TESSELLATIONS — RESULTS OF BINARY AND TERTIARY REACTIONS BETWEEN METAL IONS AND FERRICYANIDE OR FERROCYANIDE LOADED GELS
Authors: DE LACY COSTELLO B. P. J. , JAHAN I. , HAMBIDGE P. , LOCKING K. , PATEL D. , ADAMATZKY A. 
Published: July 2010

In our recent letter [de Lacy Costello et al., 2009] we described the formation of spontaneous complex tessellations of the plane constructed in simple chemical reactions between drops of metal salts and ferricyanide or ferrocyanide loaded gels. In this paper, we provide more examples of binary tessellations and extend our analysis to tessellations constructed via tertiary mixtures of reactants. We also provide a classification system which describes the tessellation based on the reactivity of the metal salt with the substrate and also the cross-reactivity of the primary products. This results in balanced tessellations where both reactants have equal reactivity or unbalanced tessellations where one reactant has a lower reactivity with the gel. The products can also be partially or fully cross reactive which gives a highly complex tessellation. The tessellations are made up of colored cells (corresponding to different metal ferricyanides or ferrocyanides) separated by bisectors of low precipitate concentration. The tessellations constructed by these reactions constitute generalized Voronoi diagrams. In the case of certain binary or tertiary combinations of reactants where the diffusion/reaction rates differ, then multiplicatively weighted crystal growth Voronoi diagrams are constructed. Where one reactant has limited or no reactivity with the gel (or the products are cross reactive) then the fronts originating from the reactive metal ions cross the fronts originating from the partially reactive metal ions. The fronts can annihilate in the formation of a second Voronoi diagram relating to the relative positions of the reactive drops. Therefore, two or more generalised or weighted Voronoi diagrams can be calculated in parallel by these simple chemical systems. However when these reactions were used to calculate an additively weighted Voronoi diagram (the reaction was initiated at different time intervals) the diagram constructed did not correspond to the theoretical calculation. We use the failure of these reactions to construct an additively weighted Voronoi diagram to prove a mechanism of substrate competition for bisector formation. These tessellations are an important class of pattern forming reactions and are useful in modeling natural pattern forming phenomena in addition to being a great resource for scientific demonstrations.
Generation of a Transgenic Mouse for Colorectal Cancer Research with Intestinal Cre Expression Limited to the Large Intestine
Authors: Xue Yingben , Johnson Robert , DeSmet Marsha , Snyder Paul W. , Fleet James C. 
Published: July 2010

Abstract
Genetically modified mice have been used for colon cancer research, but findings from these models are confounded by expression of cancer in multiple organs. We sought to create a transgenic mouse with Cre recombinase (Cre) expression limited to the epithelial cells of the large intestine and used this model to study colon cancer driven by adenomatosis polyposis coli (APC) gene inactivation. A promoter/enhancer from the mouse carbonic anhydrase I gene was used to generate a Cre-expressing transgenic mouse (CAC). After characterizing transgene expression and distribution, CAC mice were crossed to APC580S mice to generate mice with APC inactivation at one (CAC;APC580S/+) or both alleles (CAC;APC580S/580S). Transgene expression was limited to the epithelial cells of the cecum and colon, extended from the crypt base to the luminal surface, and was expressed in approximately 15% of the crypts. No abnormal gross phenotype was seen in 3- or 6-week-old CAC;APC580S/+ mice, but CAC;APC580S/580S mice had significant mucosal hyperplasia in the colon at 3 weeks, which developed into tumors by 6 weeks. By 10 weeks, 20% of CAC;APC580S/+ mice developed adenomatous lesions in the distal colon (3.0 ± 0.4 mm; 1.1 per mouse). Dextran sulfate sodium treatment increased the incidence and number of tumors, and this occurred predominantly in distal colon. Our new model has improved features for colon cancer research, that is, transgene expression is limited to the epithelium of the large bowel with normal cells found next to genetically modified cells. Mol Cancer Res; 8(8); 1095–104. ©2010 AACR.
Cooperation between the Hippocampus and the Striatum during Episodic Encoding
Authors: Sadeh Talya , Shohamy Daphna , Levy Dana Rubi , Reggev Niv , Maril Anat 
Published: July 2010

AbstractThe hippocampus and the striatum are thought to play distinct roles in learning and memory, each supporting an independent memory system. A fundamental question is whether, and how, these systems interact to jointly contribute to learning and memory. In particular, it remains unknown whether the striatum contributes selectively to implicit, habitual learning, or whether the striatum may also contribute to long-term episodic memory. Here, we show with functional magnetic resonance imaging (fMRI) that the hippocampus and the striatum interact cooperatively to support episodic memory formation. Participants were scanned during a memory encoding paradigm and, subsequently, were tested for memory of encoded items. fMRI data revealed that successful memory was associated with greater activity in both the hippocampus and the striatum (putamen) during encoding. Furthermore, activity in the hippocampus and the striatum was correlated within subjects for items that were later remembered, but not for items that were forgotten. Finally, across subjects, the strength of the correlation between the hippocampus and the striatum predicted memory success. These findings provide novel evidence for contributions of both the striatum and the hippocampus to successful episodic encoding and for a cooperative interaction between them.