bluuebunny/crossref_metadata_2025_split huggingface dataset:
A comparison of self‐reported and record‐linked blood donation history in an Australian cohort
Authors: Bertalli Nadine A. , Allen Katrina J. , McLaren Christine E. , Turkovic Lidija , Osborne Nicholas J. , Constantine Clare C. , Delatycki Martin B. , English Dallas R. , Giles Graham G. , Hopper John L. , Anderson Gregory J. , Olynyk John K. , Powell Lawrie W. , Gurrin Lyle C. ,   for the HealthIron Study Investigators
Published: April 2011

BACKGROUND: Questionnaire‐based studies investigating blood donation history rely on the accurate recall of information from participants for results to be valid. This study aimed to retrieve electronic records from a national blood donation service and link them to self‐reported history of donation to assess agreement between the two sources.STUDY DESIGN AND METHODS: Between 2004 and 2006, a sample of participants of northern European descent was selected from the Melbourne Collaborative Cohort Study (n = 31,192) to participate in the “HealthIron” study (n = 1438). A total of 1052 participants completed questionnaires that included questions about blood donation history. In 2009, consenting participants' records were linked to the Australian Red Cross Blood Service (ARCBS) to provide information on blood donations made between 1980 and follow‐up (2004‐2006). Those who commenced blood donation before 1980 were excluded.RESULTS: A total of 718 participants were available for analysis. Of these, 394 (55%) provided signed consent, including 182 (82%) of the 227 participants who self‐reported ever donating blood. The two data sources were concordant for 331 (87%) of participants, with a κ statistic of 0.74 (SE, 0.05) indicating a high level of agreement. Participants tended to overstate by a factor of 2.0 (95% confidence interval, 1.7‐2.2) the number of donations they had made when compared with ARCBS records.CONCLUSION: Participants in studies assessing self‐reported blood donation history are likely to correctly indicate whether or not they have ever donated blood. Quantitative estimates are potentially inaccurate and could benefit from validating a sample of records to quantify the bias.
Similar cation channels mediate protection from cerebellar exitotoxicity by exercise and inheritance
Authors: Ben‐Ari Shani , Ofek Keren , Barbash Shahar , Meiri Hanoch , Kovalev Eugenia , Greenberg David Samuel , Soreq Hermona , Shoham Shai 
Published: April 2011

AbstractExercise and inherited factors both affect recovery from stroke and head injury, but the underlying mechanisms and interconnections between them are yet unknown. Here, we report that similar cation channels mediate the protective effect of exercise and specific genetic background in a kainate injection model of cerebellar stroke. Microinjection to the cerebellum of the glutamatergic agonist, kainate, creates glutamatergic excito‐toxicity characteristic of focal stroke, head injury or alcoholism. Inherited protection and prior exercise were both accompanied by higher cerebellar expression levels of the Kir6.1 ATP‐dependent potassium channel in adjacent Bergmann glia, and voltage‐gated KVbeta2 and cyclic nucleotide‐gated cation HCN1 channels in basket cells. Sedentary FVB/N and exercised C57BL/6 mice both expressed higher levels of these cation channels compared to sedentary C57BL/6 mice, and were both found to be less sensitive to glutamate toxicity. Moreover, blocking ATP‐dependent potassium channels with Glibenclamide enhanced kainate‐induced cell death in cerebellar slices from the resilient sedentary FVB/N mice. Furthermore, exercise increased the number of acetylcholinesterase‐positive fibres in the molecular layer, reduced cerebellar cytokine levels and suppressed serum acetylcholinesterase activity, suggesting anti‐inflammatory protection by enhanced cholinergic signalling. Our findings demonstrate for the first time that routine exercise and specific genetic backgrounds confer protection from cerebellar glutamatergic damages by similar molecular mechanisms, including elevated expression of cation channels. In addition, our findings highlight the involvement of the cholinergic anti‐inflammatory pathway in insult‐inducible cerebellar processes. These mechanisms are likely to play similar roles in other brain regions and injuries as well, opening new venues for targeted research efforts.
Histological evaluation of healing after transalveolar maxillary sinus augmentation with bioglass and autogenous bone
Authors: Stavropoulos Andreas , Sima Catalin , Sima Andrea , Nyengaard Jens , Karring Thorkild , Sculean Anton 
Published: April 2011

Abstract
Objectives: The aim was to evaluate histologically the outcome of a bioglass and autogenous bone (at 1 : 1 ratio) composite implantation for transalveolar sinus augmentation.
Methods: In 31 patients, during implant installation ca. 4 months after sinus augmentation, biopsies were harvested through the transalveolar osteotomy by means of a trephine bur and non‐decalcified sections through the long axis of the cylinder were produced. After a strict selection process, taking into account the presurgical residual bone height and biopsy length, 8 and 15 biopsies representing the new tissues formed inside the sinus and the transalveolar osteotomy, respectively, qualified for analysis. The tissue fractions occupied by newly formed bone (mineralized tissue+bone marrow), soft connective tissue, residual biomaterial+empty spaces, and debris inside the sinus cavity or the transalveolar osteotomy were estimated.
Results: Bone and connective tissue fraction in the newly formed tissues inside the sinus cavity averaged 23.4 ± 13.2% and 54.1 ± 23.5%, respectively. Residual biomaterial, empty spaces, and debris averaged 1.9 ± 3.5%, 10.5 ± 6.3%, and 8.4 ± 14.5%, respectively. In the transalveolar osteotomy, bone and connective tissue fraction averaged 41.6 ± 14.3% and 46.1 ± 13%, respectively, while the amount of residual biomaterial, empty spaces, and debris was 2.8 ± 5%, 4.7 ± 1.9%, and 3.2 ± 2.6%, respectively. Statistically significant differences between the sinus cavity and the transalveolar osteotomy were found only for bone and empty spaces' values (P=0.02 and 0.04, respectively).
Conclusion: Sinus augmentation with a bioglass and autogenous bone composite is compatible with bone formation that, in a short distance from the floor of the sinus, shows similar density as that reported previously for other commonly used bone substitutes. New bone fraction inside the transalveolar osteotomy was almost twice as much as in the sinus cavity, while the amount of residual biomaterial was much less than that inside the sinus.
To cite this article: Stavropoulos A, Sima C, Sima A, Nyengaard J, Karring T, Sculean A. Histological evaluation of healing after transalveolar maxillary sinus augmentation with bioglass and autogenous bone. Clin. Oral Impl. Res. 23, 2012; 125–131. doi: 10.1111/j.1600‐0501.2011.02161.x
Removable four implant‐supported mandibular overdentures rigidly retained with telescopic crowns or milled bars: a 3‐year prospective study
Authors: Krennmair Gerald , Sütö Daniel , Seemann Rudolf , Piehslinger Eva 
Published: April 2011

Abstract
Purpose: The present study evaluated implant survival/success rate, peri‐implant parameters and prosthodontic maintenance efforts for four implant‐supported mandibular overdentures (IOD) rigidly retained on either milled bar or double crowns (telescopic) attachments.
Material and methods: In a randomized prospective trial, 51 patients with edentulism received four mandibular interforaminal implants and complete maxillary dentures. For IOD, rigid denture stabilization was chosen randomly selecting 26 patients for milled bars (group I) and 25 patients for double (telescopic) crowns (group II). During a 3‐year follow‐up period, implant survival/success, peri‐implant parameters (marginal bone resorption, pocket depth, plaque‐, bleeding‐, gingival index [BI and GI], calculus) and prosthodontic maintenance efforts were evaluated and compared between both retention modalities used.
Results: Forty‐five patients (23 group I, 22 group II) were available for a 3‐year follow‐up (dropout rate: 11.8%) presenting a high implant survival/success rate (100%). Peri‐implant marginal bone resorption, pocket depth as well as BI and GI did not differ for both rigid retention modalities. However, annually higher values for plaque‐ (NS) and calculus index (P<0.035) were noticed for the bar (group I) than for the telescopic crown (group II) attachments. Prevalence of prosthodontic maintenance did not differ between both retention modalities (group I: 0.41/maintenance efforts/year/patients vs. group II; 0.45 maintenance/efforts/year/patients). However, prosthodontic adaption for handling mechanism showed benefits for the bar retention.
Conclusion: Rigid anchoring of IOD retained either by bar or telescopic attachments showed high implant success rates and minor prosthodontic maintenance efforts regardless of retention modalities used. Stable denture retention presented healthy peri‐implant structure for implants in bar and telescopic anchoring systems. Drawbacks such as higher plaque/calculus for bar retention and less favorable handling properties (output) for telescopic crown attachment leave the decision on the selection at the discretion of the clinician.
To cite this article: Krennmair G, Sütö D, Seemann R, Piehslinger E. Removable four implant‐supported mandibular overdentures rigidly retained with telescopic crowns or milled bars: a 3‐year prospective study. Clin. Oral Impl. Res. 23, 2012 481–488. doi: 10.1111/j.1600‐0501.2011.02169.x
Immediately restored one‐piece single‐tooth implants with reduced diameter: one‐year results of a multi‐center study
Authors: Zembić A. , Johannesen L. H. , Schou S. , Malo P. , Reichert T. , Farella M. , Hämmerle C. H. F. 
Published: April 2011

Abstract
Objectives: The aim of the present multi‐center study was to evaluate the treatment outcome of immediately restored one‐piece single‐tooth implants with a diameter of 3 mm after 1 year.
Material and methods: A total of 57 one‐piece implants (NobelDirect® 3.0) were inserted in 47 patients (26 females, 21 males) with a mean age of 31 years (range: 17–76 years) at five different centers. The implants replaced maxillary lateral incisors and mandibular incisors. The implants were placed either in conjunction with tooth extraction or in healed sites, and all implants were immediately restored with a provisional resin crown. If needed, the abutment part of the implant was prepared before crown cementation. The permanent crown was placed after 1.9–14.5 months. Radiographs were taken at implant insertion as well as after 6 and 12 months to evaluate the peri‐implant marginal bone level and bone loss. Moreover, plaque, bleeding on probing and complications were assessed.
Results: A total of 44 patients (23 females, 21 males) with 54 implants were available for the 1‐year follow‐up. One implant was lost, thus the 1‐year implant survival was 98%. A statistically significant mean marginal bone loss was observed between baseline and 6 months (1.1 mm, range: −0.7 to 4.4 mm; n=49) and between baseline and 12 months (1.6 mm, range: −0.8 to 4.6 mm; n=50). A total of 18% of the implants were characterized by a bone loss of more than 3 mm. No bleeding on probing was observed around 83% of the implants. Plaque was registered at 15% of the implants. The most common complications were related to the provisional crown, i.e. fracture (n=3) and loss of retention (n=3).
Conclusions: A high 1‐year implant survival was observed in the present study. However, the excessive peri‐implant marginal bone loss around several implants indicates that this implant should be used with caution until further studies have been conducted.
To cite this article: Zembić A, Johannesen LH, Schou S, Malo P, Reichert T, Farella M, Hämmerle CHF. Immediately restored one‐piece single‐tooth implants with reduced diameter: one‐year results of a multi‐center study. Clin. Oral Impl. Res. 23, 2012; 49–54. doi: 10.1111/j.1600‐0501.2011.02174.x
A case‐control study assessing oral‐health‐related quality of life after immediately loaded single implants in healed alveolar ridges or extraction sockets
Authors: Raes Filiep , Cooper Lyndon F. , Tarrida Luís Giner , Vandromme Heleen , De Bruyn Hugo 
Published: April 2011

AbstractIntroduction: Tooth loss reduces oral‐health‐related quality of life (OHRQoL) as assessed with the 14‐item Oral Health Impact Profile questionnaire (OHIP‐14).Objectives: This prospective multicenter case‐control study sought to (i) establish OHRQoL in patients requiring a single implant in the anterior maxilla and to (ii) compare these changes following implant placement and immediate provisionalization in extraction sockets with healed alveolar ridges up to 1 year.Material and methods: Ninety‐six patients were enrolled in the study with 102 single implants (OsseoSpeed™ AstraTech) provisionalized immediately after placement in sockets or after placement in healed ridges. A final crown was cemented after 12 weeks. OHIP‐14 was registered before surgery (baseline), after 1 (provisional crown), 6 and 12 months (final crown). Repeated measures ANOVA was performed for the seven conceptual OHIP Domains, the treatment group (extraction site socket vs. healed alveolar ridge) and time as within subjects variables.Results: Two implants failed, 1/48 (2.1%) in the extraction group (n=46 patients) and 1/54 (1.8%) in the healed ridge group (n=50 patients). From 82 patients (87.5%), OHIP‐14 was available at all time points. The overall OHIP‐14 based on the mean of the seven domains increases between baseline and 6 months and remained stable afterward for the total study group and both treatment groups. Comparison between extraction and healed groups revealed no significant difference at baseline but the healed group showed a significantly higher improvement for functional limitation, physical disability, physical pain and psychological discomfort (P<0.05). Between baseline and 1 year in the healed bone group, all seven domains improved significantly compared with only three domains in the extraction group. However, the overall OHIP‐14 score between groups was not substantially different. Hence, both treatment modalities lead to similar OHRQoL improvement.Conclusion: Patients in need of a single‐tooth replacement have limited OHRQoL problems as reflected by the OHIP‐14 score but improvements in several domains related to oral health were evaluated when implants were placed and provisionalized in healed bone and extraction sites.
Evaluation of an anorganic bovine‐derived mineral with P‐15 hydrogel bone graft: preliminary study in a rabbit cranial bone model
Authors: Matos Sérgio , Guerra Fernando , Krauser Jack T. , Figueiredo Helena , Marcelino João Pedro , Sanz Mariano 
Published: April 2011

AbstractObjectives: The present investigation aimed to assess the bone‐regenerative potential of two formulations of anorganic bovine‐derived mineral bound to a P‐15 (ABM/P‐15) bone graft – the particulate and the hydrogel forms – in a delayed healing rabbit cranial defect model.Material and methods: Ten adult male New Zealand White rabbits were used to create two 8 mm transcortical cranial defects per rabbit and each one received randomly the test material (ABM/P‐15 carboxymethyl cellulose (CMC)‐hydrogel graft), the standard control material (ABM/P‐15 particulate graft) or remained empty as a negative control. The defects were allowed to heal for 2 and 4 weeks. Qualitative and quantitative histological outcomes were assessed on undecalcified sections.Results: In the defects grafted with the test material, at both time points, there was a marked random migration of the bone substitute particles. As a consequence, the space maintenance provision was lost and new bone formation was reduced compared with the control particulate graft material. The histomorphometric analysis showed that the control material attained better results, with an average of 13.8 ± 1.9% and 18.2 ± 4.4% of new bone at 2 and 4 weeks, compared with 8.5 ± 2.4% and 13 ± 2.9% for the test material. These differences were significant at 2 weeks (P≤0.05), but not at 4 weeks (P>0.05). Additionally, there was a significant difference in the total area of mineralized tissue (new bone plus particles), favoring the standard control over the test material: 43.2 ± 14.4% vs. 14.2 ± 5.3% at 2 weeks and 56.9 ± 4.2% vs. 24.2 ± 9.6% at 4 weeks, respectively.Conclusions: The test ABM/P‐15 CMC‐hydrogel graft material behaved in this animal model by migration of the graft particles, what determined an unpredictable osseoconduction and, consequently, a decreased quality and quantity of bone regeneration as compared with the osseopromotive behavior exhibited by the standard particulate form of the ABM/P‐15 control graft. It is therefore suggested to restrain the application of the hydrogel graft form in non‐contained anatomical bone defects.
Microchimerism in labial salivary glands of hematopoietic stem cell transplanted patients
Authors: Souza LN , Faria DR , Dutra WO , Gomes CC , Gomez RS 
Published: April 2011

Oral Diseases (2011) 17, 484–488Objective:  Microchimerism has been extensively investigated in autoimmune diseases, which display similarities with graft‐vs‐host disease. This study was conducted to investigate the presence of microchimerism in minor salivary glands of hematopoietic stem cell transplanted patients, one of the targets of graft‐vs‐host disease.Methods:  Labial salivary glands biopsy specimens from 11 stem cell transplanted patients were analysed. The samples were grouped in control (five specimens from a female‐to‐female transplantation) and study group (five glands from male‐to‐female transplantation). One male transplanted patient was used as a positive control. Fluorescence in situ hybridization with Y‐chromosome probe and immunofluorescence with anticytokeratin AE1/AE3 and CD45 were used to identify Y‐chromosome positive glandular epithelial cells from allogeneic hematopoietic stem cell transplanted patients.Results:  In the study group, all samples were positive to Y‐chromosome and cytokeratin AE1/AE3, in agreement with the pattern exhibited by male labial salivary gland. None of the samples from control group were positive to Y‐chromosome despite being positive to cytokeratin AE1/AE3. Positivity to CD45 was not relevant.Conclusion:  Microchimerism in the labial salivary glands of sex‐mismatched stem cell transplanted patients is a real phenomenon. Further studies are necessary to elucidate the impact of this phenomenon on the clinical status of stem cell transplanted patients.
Normative data for tests of neuromuscular performance and DXA‐derived lean body mass and fat mass in pre‐pubertal children
Authors: Lundgren Susanna Stenevi , Nilsson Jan Åke , Ringsberg Karin AM , Karlsson Magnus K 
Published: April 2011

AbstractAim:  To present gender‐specific normative data on estimates of neuromuscular performance, such as muscle strength, vertical jump and standing unilateral balance, in pre‐pubertal children.Methods:  Lean body mass (kg) and fat mass (%) were estimated by dual‐energy X‐ray absorptiometry in 246 boys and 190 girls aged 6–12 years in Tanner stages 1 and 2. Isokinetic concentric peak torque at 60 and 180°/sec of the right knee extensors, and flexors were evaluated by a computerized dynamometer. Vertical jump height (VJH) was evaluated with an electronic mat and postural control with a one‐leg stand test and a blindfolded one‐leg stand test.Results:  Anthropometry, muscle strength and VJH in both genders showed improved performance with advancing ages (all p < 0.01 for trend) but there were no constant gender differences across the age groups (all ns.). In boys and girls, the ratio muscle strength/muscle mass showed significantly higher ratios with higher ages (both p < 0.01, respectively), but with no constant gender discrepancy. The postural control tests also showed significantly better performance with higher ages in both boys and girls (both p < 0.01).Conclusion:  This report, which provides normative gender‐specific data on muscle strength, muscle and fat mass and VJH, shows that in Swedish children aged 6–12 years, there seems to be a linear increase with age and no structural gender differences.
Parent‐reported food allergy requiring an avoidance diet in children starting elementary school
Authors: Kallio P , Salmivesi S , Kainulainen H , Paassilta M , Korppi M 
Published: April 2011

AbstractAim:  To evaluate the prevalence of parent‐reported food allergies requiring avoidance diet at early school age.Methods:  The school health nurses interviewed, by using a structured questionnaire on the required diet at school, the parents of all the 1542 children starting elementary school in a Finnish town with 210 000 inhabitants.Results:  An allergy to basic foods was found in 41 (2.7%) children: 1.5% to milk, 1.1% to eggs and 1.0% to grains. An allergy to nuts was present in 3.1% and to fruits and vegetables in 5.8%, both with known cross‐sensitization to pollens. In all, 9.2% of the children reported some allergy. Milk, egg and grain allergies were associated with soy, nut and spice allergies.Conclusion:  Over 2% of the 1542 Finnish first‐graders reported allergies to basic foods (milk, eggs or grains) requiring special avoidance diets at school. The figure suggests that avoidance diets started in the first years of life still unnecessarily continued.
Prediction of obesity from infancy to adolescence
Authors: Angbratt Marianne , Ekberg Joakim , Walter Lars , Timpka Toomas 
Published: April 2011

AbstractAim:  To examine the development of childhood obesity and to determine the earliest age when estimating body mass using only weight and height data is associated with a corresponding estimate at the age of 15.Methods:  Subjects included are all children born in 1991 in Östergötland County, Sweden. Weight and height data collected during regular check‐ups at well‐child centres and school health care assessments up to 15 years of age were assembled from health records. Correlations between childhood estimates of body mass and the body mass index (BMI) at 15 years of age were computed pairwise. Correlations with r > 0.5 were defined as reliably strong.Results:  Complete data were available for 3579 children (62%). Fewer girls (2.6%; C.I. 1.9–3.3) than boys (4.6%; C.I. 3.7–5.5) were obese at 15 years of age. Correlations with BMI at 15 years of age were strong (significantly higher than 0.5) from 5 years of age. Only 23% of girls and 8% of boys found to be obese at 5 years of age were of normal weight at the age of 15.Conclusion:  From 5 years of age, point estimates of body mass using only weight and height data are strongly associated with BMI at the age of 15. More data sources are needed to predict weight trajectories in younger children.