bluuebunny/crossref_metadata_2025_split huggingface dataset:
Role of N-acetyl-N-nitroso-tryptophan as nitric oxide donor in the modulation of HIF-1-dependent signaling
Authors: Berchner-Pfannschmidt Utta , Tug Suzan , Hu Jun , Reyes Buena Delos , Fandrey Joachim , Kirsch Michael 
Published: March 2010

Abstract

N-Acetyl-N-nitroso-tryptophan (NANT) is well known for its capacity to generate nitric oxide (NO)-releasing compounds. It is unknown, however, whether NANT can be successfully applied as a precursor of NO in a complex biological environment such as a cell culture system. NO donors can be useful to induce the transcription factor hypoxia-inducible factor 1 (HIF-1) that coordinates the protection of cells and tissues from the lack of oxygen, termed hypoxia. HIF-1 degradation is controlled by prolyl hydroxylase 2 (PHD2) which needs to be inhibited for HIF-1 accumulation. Here, the effects of NANT in inhibiting recombinant PHD2 and up-regulating of HIF-1 and HIF-1-mediated carboanhydrase-9 (CA9) mRNA expression were compared in living cells with the NO donors N-nitrosomelatonin (NOMela) and S-nitrosoglutathione (GSNO) under normoxic and hypoxic conditions. In contrast to GSNO, NANT was similar to NOMela being highly effective in inhibiting recombinant PHD2. NANT-mediated activation of HIF-1 in oxygenated cells was comparable to hypoxic activation of HIF-1 in all cases. In contrast, under hypoxia NANT was able to boost hypoxic cellular HIF-1 levels by further reducing the activity of cellular PHD2. The strong increase of HIF-dependent CA9 mRNA expression demonstrated that NANT-induced HIF-1 was transcriptionally active. Finally, the efficacy of NANT to increase both HIF-1 and CA9 mRNA did not depend on the absolute conformation of the tryptophan moiety. In conclusion, NANT appears to be an excellent NO donor for cells in culture and l-NANT should be useful for in vivo animal studies.
Laboratory Study of Soft Soil Improvement using Lime Mortar-(Well Graded) Soil Columns
Authors: Malekpoor Mohammad Reza , Toufigh Mohammad Mohsen 
Published: March 2010

AbstractStone columns and sand compaction piles represent the most known column-type technique for improving soft soils. In this study, more than 675 laboratory tests were carried out on composite specimens with lime mortar-well graded soil (lime-WS) column. These tests were conducted on specimens prepared as lime-WS using a mixture of lime and well graded soil poured into a local clay soil material with various proportions of lime and different curing times. The test programs were designed to investigate influences of variations in the moisture content on composite specimens. All tests were performed on specimens based on the classical California bearing ratio (CBR) testing procedure according to ASTM D1883–94. Test results were used to train an artificial neural network (ANN). ANN makes it possible to predict the behavior of these columns and their load bearing capacity as a function of changes in clay and lime content with different curing times. Tests results show that lime-WS columns, which contain 20 % lime and 22 % clay, increase the strength of soft fine grained soils to a noticeable amount.
Culturally-Sensitive Information-Sharing in Pediatric Palliative Care
Authors: Davies Betty , Contro Nancy , Larson Judith , Widger Kimberley 
Published: March 2010

OBJECTIVES:
This study aimed to learn about experiences of Mexican American and Chinese American families who require pediatric palliative care. This article describes parents' perceptions of information-sharing by health care providers during their child's hospitalizations and at their child's death.

METHODS:
The study used a retrospective design of grounded theory analysis. Participants included 36 parents (26 Mexican American and 10 Chinese American) from 28 families who experienced between 6 months and 5 years before study participation the death of a child who was aged ≤20 years. Participants were recruited through 2 university hospitals in northern California.

RESULTS:
Parents' identified 3 types of information shared by health care providers: (1) information about the child's daily life in hospital; (2) information about the parents' daily life in hospital; and (3) information about treatment and end-of-life issues. Parents' narratives focused primarily on information shared by physicians; nurses, social workers, chaplains, interpreters, and other parents were also important sources of information. Four patterns of information-sharing emerged: (1) no information; (2) basic information; (3) basic information plus implications; and (4) basic information plus implications plus attention to parents' questions, concerns, and emotions. Positive and negative impacts of these patterns on parents are described.

CONCLUSIONS:
Language and cultural differences create barriers to information-sharing by health care providers to parents who are in need of pediatric palliative care. Less than optimal patterns of information-sharing contribute to frustration, anger, and sadness for parents long after their child's death.
Widespread Vitamin D Deficiency in Urban Massachusetts Newborns and Their Mothers
Authors: Merewood Anne , Mehta Supriya D. , Grossman Xena , Chen Tai C. , Mathieu Jeffrey S. , Holick Michael F. , Bauchner Howard 
Published: March 2010

OBJECTIVE:
To determine vitamin D status and associated factors in a cohort of newly delivered infants and their mothers in Boston, Massachusetts.

PATIENTS AND METHODS:
Enrollment in this cross-sectional study took place from 2005 to 2007 in an urban Boston teaching hospital with 2500 births per year. A questionnaire and medical-record data were used to identify variables that are potentially associated with vitamin D deficiency (25-hydroxyvitamin D [25(OH)D] &lt; 20 ng/mL). Infant and maternal blood was obtained by venipuncture within 72 hours of birth. The main outcome measure was infant and maternal 25(OH)D status, assessed by competitive protein binding.

RESULTS:
We enrolled 459 healthy mother/infant pairs. After subsequent exclusions, analyses were performed on 376 newborns and 433 women. The median infant 25(OH)D level was 17.2 ng/mL (95% confidence interval [CI]: 16.0–18.8; range: &lt;5.0 to 60.8 ng/mL). The median maternal 25(OH)D level was 24.8 ng/mL (95% CI: 23.2–25.8; range: &lt;5.0 to 79.2 ng/mL). Overall, 58.0% of the infants and 35.8% of the mothers were vitamin D deficient (25[OH]D &lt; 20 ng/mL); 38.0% of the infants and 23.1% of the mothers were severely deficient (25[OH]D &lt; 15 ng/mL). Risk factors for infant vitamin D deficiency included maternal deficiency (adjusted odds ratio [aOR]: 5.28 [95% CI: 2.90–9.62]), winter birth (aOR: 3.86 [95% CI: 1.74–8.55]), black race (aOR: 3.36 [95% CI: 1.37–8.25]), and a maternal BMI of ≥35 (aOR: 2.78 [95% CI: 1.18–6.55]). Maternal prenatal-vitamin use throughout the second and third trimesters was protective against infant deficiency (aOR: 0.30 [95% CI: 0.16–0.56]). Similarly, prenatal-vitamin use of ≥5 times per week in the third trimester was protective for mothers (aOR: 0.37 [95% CI: 0.20–0.69]). Despite this, &gt;30% of the women who took prenatal vitamins were still vitamin D deficient at the time of birth.

CONCLUSIONS:
A high proportion of infants and their mothers in New England were vitamin D deficient. Prenatal vitamins may not contain enough vitamin D to ensure replete status at the time of birth.
Degradation Mechanism of GaN-based LEDs With Different Growth Parameters
Authors: Ka Kuen Leung , Fong W.K. Patrick , Chan Paddy Kwok Leung , Surya Charles 
Published: March 2010

AbstractWe investigated the degradation mechanism of GaN LEDs due to the application of a high d.c. stressing current. To identify the underlying process for device failure we examined the effects of the InGaN quantum well growth parameters on the hot-electron hardness of the devices. Systematic characterizations on the degradations in the microstructural, thermoreflectance, and low frequency noise properties of the devices were performed.
Structural and Magnetic Properties of Zn1-xCoxO Nanoparticles Prepared by a Simple Sol-Gel Method at Low Temperature
Authors: Jáuregui-Rosas Segundo R. , Perales-Perez Oscar , Urcia-Romero S. , Asmat-Uceda M. , Quezada-Castillo E. 
Published: March 2010

AbstractPure and Zn1-xCoxO nanoparticles have been synthesized by a simple sol-gel method at low temperature where neither a chelating agent nor subsequent annealing was required. The effect of Cobalt atomic fraction, ‘x’ ≤ 0.0625, on the structural and magnetic properties of the doped ZnO powders was evaluated. X-ray diffraction and Fourier-transform infrared spectroscopy analyses evidenced the exclusive formation of the ZnO-wurtzite structure; no isolated Co-phases were detected. The linear dependence of cell parameters a and c with ‘x’, suggested the actual replacement of Zn by Co ions in the oxide lattice. Micro Raman spectroscopy measurements showed a band centered at 534cm-1, which can be assigned to a local vibrational mode related to Co species, in addition to the normal modes associated with wurtzite. The intensity and broadening of this band at 534 cm-1 were enhanced by increasing ‘x’. In turn, the other bands corresponding to A1 (E2, E1) and E2High modes were red shifted at higher Co contents. Room-temperature magnetization measurements revealed the paramagnetic behavior of the Co-doped ZnO nanoparticles.
Interactions between Single-Walled Carbon Nanotubes (SWNT) and Ciliates: SWNT Interfere with Ciliate Ecological Functions and Ciliates Transport/Transform SWNT
Authors: Chan Tiffany S. Y. , Nasser Fatima , St-Denis Christine H. , Bols Niels C. , Tang Shirley 
Published: March 2010

AbstractWe investigated the interactions of water soluble single-walled carbon nanotubes (SWNT) with unicellular organisms, in particular a ciliated protozoan (Tetrahymena thermophila) and a bacteria (Escherichia coli), which are common constituents of natural fresh water. The ciliates could effectively incorporate SWNT into natural organic matter (NOM), and therefore into normal ecological processes. Further, SWNT induced the ciliates to egest viable bacteria in membrane-enclosed vesicles. The egested bacteria aggregates had escaped digestion by the protozoan and were able to proliferate and resist antibiotic/disinfectant treatments, which may have important implications to public health. This work highlights the importance of studies on nanoparticle ecotoxicology.
Exciton Nonlinearities and Optical Gain in Colloidal CdSe/CdS Dot/rod Nanocrystals
Authors: Saba Michele , Marceddu Marco , Quochi Francesco , Minniberger Stefan , Roither Jürgen , Gocalinska Agnieszka , Kovalenko Maksym V , Talapin Dmitri V , Heiss Wolfgang , Mura Andrea , Bongiovanni Giovanni 
Published: March 2010

AbstractWe characterized the optical nonlinearities of CdSe nanocrystals surrounded by rod-like CdS shells with ultrafast measurements of time-resolved photoluminescence. We measured the exciton-exciton interaction to be, depending on structure details, attractive or repulsive, by as much as 29 meV, due to the unique band alignment in the CdSe/CdS. This feature makes CdSe/CdS dot/rods promising gain media for solution-processable lasers, as it appears combined with 80% photoluminescence quantum yield, narrow size and shape distributions and the antenna effect of the CdS rod shell enhancing optical absorption by more than a factor 50 with respect to bare dots.
SERS Study of Alizarin Red Dye on Colloidal Silver Nanoparticles
Authors: Swarnkar Raj Kumar , Singh Subhash Chandra , Gopal Ram 
Published: March 2010

AbstractThe present paper deals with surface enhanced Raman scattering (SERS) study of an organic dye Alizarin Red on colloidal silver nanoparticles. The colloidal solution of nanoparticles is synthesized by pulsed laser ablation of silver rod in pure deionized water using focused out put of 1064nm wavelength of Nd:YAG laser having 35mJ/ pulse energy. Sodium chloride is used as aggregating agents. It is observed that SERS enhancement factor varies strongly depending on concentration of used aggregating agent (especially on the concentration of Cl- ions). These changes in SERS efficiency of colloid are reflected through changes on the absorption spectra. The possible mechanism of SERS is also discussed.
Sex‐Age Selectivity and Correlates of Capture for Winter‐Trapped White‐Tailed Deer
Authors: HILLER TIM L. , BURROUGHS JORDAN PUSATERI , CAMPA HENRY , COSGROVE MELINDA K. , RUDOLPH BRENT A. , TYRE ANDREW J. 
Published: March 2010

ANDREW J. TYRE7ABSTRACT  Despite the common use of Clover traps to capture white‐tailed deer (Odocoileus virginianus), little published information exists quantifying trap success, trap selectivity (sex‐age selection), or weather correlates of trap success. We quantified these relationships using white‐tailed deer data from 3 study sites in the Lower Peninsula of Michigan, USA, during winters 2001–2007. We captured 610 deer in 8,569 trap‐nights; pooled capture success was 0.07 deer/trap‐night, although site‐year success varied from 0.021 to 0.086. We compared sex‐age classes (fawn [pooled by sex], ad M, ad F) captured with sex‐age classes estimated to be available on each study site during each capture season. We used generalized linear mixed modeling to construct 19 a priori models to describe probability of capture success as a function of weather covariates (daily min. temp [° C], daily snowfall [cm], daily snow depth [cm]), Julian day, site, and year. General selection patterns included fawns captured more than expected and adult males captured less than expected; adult females were generally neutrally selected. The quasi‐Akaike's Information Criterion best model within our set was described by the global model without Julian day and contained all 3 weather covariates and site‐year effects. Our model provided some evidence that as daily snow depth increased, probability of capture increased; the positive effect of daily snowfall on capture probability was dependent on decreasing daily minimum temperature. Our results may be used to increase efficacy of deer capture programs by researchers and managers through informed decision‐making about when to allocate effort (e.g., if extreme winter weather conditions are predicted) and when to consider alternative methods (e.g., if capture of ad M is an objective).
In Situ Study of In-office Bleaching Procedures Using Light Sources on Human Enamel Microhardness
Authors: Araujo F. O. , Baratieri L. N. , Araújo É 
Published: March 2010

Clinical RelevanceRegardless of the light sources used, the microhardness of human dental enamel did not present significant changes 14 days after in-office bleaching.
Effect of Dual Cure Composite as Dentin Substitute on the Marginal Integrity of Class II Open-Sandwich Restorations
Authors: Koubi S. , Raskin A. , Dejou J. , About I. , Tassery H. , Camps J. , Proust J-P. 
Published: March 2010

Clinical Relevance
Dual-curing composites may present a good alternative to RMGIC in open-sandwich restorations and act as a dentin substitute. However, this study showed that RMGIC remains the best intermediate material when open-sandwich restorations are indicated.
Intimacy: From Transformation to Transmutation
Authors: Bianchi Gabriel 
Published: March 2010

Intimacy: From Transformation to Transmutation
The paper reflects the historical and current dynamism of the concept of intimacy. Besides differences between scientific disciplines in understanding what the substance of intimacy is, the recent discourse on change in intimacy has been dominated by the transformation theme introduced by Anthony Giddens (1992). Led by reflections of Richard Sennett (1986) the author draws attention to the opposite aspect of change in intimacy—the change in content, or the "transmutation" of intimacy. Transmutation of intimacy—the substitution of the satisfaction of intimate needs with identity creation—not only contests the very essence of intimacy, but also constitutes a significant challenge for the project of intimate citizenship (Plummer 2003).
Sexual Orientation as Symbolic Capital and as the "Object" of Symbolic Violence
Authors: Kövérová Štefánia 
Published: March 2010

Sexual Orientation as Symbolic Capital and as the "Object" of Symbolic Violence
Sexual orientation is currently understood to be an innate disposition. Heterosexually oriented people are perceived to be in the majority and homosexually oriented people as the minority. Using Pierre Bourdieu's concepts of symbolic power, symbolic violence and symbolic capital, this paper aims to show how symbolic power and symbolic violence contribute to determining which sexual orientation is associated with the majority and minority populations, and establish what role is played by the symbolic capital derived from sexual orientation.
On-Line Discussion and Public Deliberation
Authors: Ondrušek Dušan 
Published: March 2010

On-Line Discussion and Public Deliberation
This paper surveys how the principles of the development of collective intelligence in on-line discussion and the consequences of the open source movement can influence the shape and recommended format of public deliberation processes. It raises the question of the conditions and factors which explain the difference in the quality of discussion results when technological issues are discussed and when values are discussed. It also raises the question of the importance of formats and types of facilitation which allow for deliberation to be structured towards achieving better productivity and the more effective participation of discussion participants.
A Shandon PapSpin liquid-based gynecological test: A split-sample and direct-to-vial test with histology follow-up study
Authors: Rimiene J , Petronytė J , Gudleviciene Z , Giedrė Smailytė , Ingrida Krasauskaite , Laurinavicius A 
Published: March 2010

Background:Studies for liquid-based Papanicolaou (Pap) tests reveal that liquid-based cytology (LBC) is a safe and effective alternative to the conventional Pap smear. Although there is research on ThinPrep and SurePath systems, information is lacking to evaluate the efficiency and effectiveness of systems based on cytocentrifugation. This study is designed to determine the sensitivity and specificity of the Shandon PapSpin (ThermoShandon, Pittsburgh, Pennsylvania, USA) liquid-based gynecological system. We used split-sample and direct-to-vial study design.Materials and Methods:2,945 women referred to prophylactic check-up were enrolled in this study. Split sample design was used in 1,500 women and residual cervical cytology specimen from all these cases was placed in fluid for PapSpin preparation after performing conventional smear. The direct-to-vial study was carried out in another cohort of 1,445 women in whom the entire cervical material was investigated using only the PapSpin technique. Follow up histological diagnoses for 141 women were obtained from both study arms following 189 abnormal cytology cases. 80 LBC cases from the split sample group and 61 LBC cases in the direct-to-vial group were correlated with the histology results. The sensitivity and secificity of the conventional smear and PapSpin tests in both study arms were compared.Results:In the split sample group, conventional smears showed a higher proportion of ASC-US (atypical cells undetermined significance): 31 (2.1%)vs10 (0.7%) in PapSpin (P= 0.001). A higher proportion of unsatisfactory samples was found in the conventional smear group: 25 (1.7%)vs6 (0.4%) cases (P= 0.001). In the split sample group, the sensitivity of the conventional and PapSpin tests was 68.7%vs78.1%, and the specificity 93.8%vs91.8%, respectively. In the direct to vial group PapSpin sensitivity was 75.9% and specificity 96.5%. The differences in sensitivity and specificity were not significant. The positive predictive values for the conventional and PapSpin methods were not different in the split sample group: 88.0%vs86.2% and 95.7% in the direct-to-vial group. Also, no differences were found for negative predictive value (82.1, 86.8% and 80.0% respectively).Conclusions:PapSpin showed good qualitative results in both study arms, even after the material splitting in the first study arm, and is a good alternative to the conventional Pap smear. Additionally, the PapSpin method offers several advantages such as the opportunity to prepare duplicate slides, option for HPV DNA testing and cell block preparations from residual material. Microscopic evaluation of thinner cell preparations is less time consuming than the conventional Pap smears.
Feeding Tube Enterostomies in Upper Aerodigestive Tract Cancers
Authors: Saumitra Saha , Anandabrata Bose , Pankaj Chowdhary 
Published: March 2010

AbstractEstablishment and maintenance of safe access is crucial for long-term enteral nutrition in patients with head-neck and esophagogastric cancers. Tube enterostomies such as gastrostomy and jejunostomy are being increasingly used with wider use of chemoradiation and adjuvant therapy following surgery. This article reviews the currently available enteral access techniques by the open and percutaneous route and their indications, safety, effectiveness and role in modern oncological practice.
Nonsyndromic Type of Multiple Basal Cell Carcinoma
Authors: Anil D'Cruz , Pankaj Chaturvedi , Devendra Chaukar , Amit Ghatge , Prathamesh Pai , Gouri Pantvaidya 
Published: March 2010

AbstractWe report a case of nonsyndromic type of multiple basal cell carcinoma associated purely with actinic keratoses. A 69-year-old Indian male had suffered from multiple, variable-sized papules and nodules on the face, neck and chest for 13 years previous to treatment. He had no history of arsenic intake, irradiation, herb medication, or exposure to chemical warfare gases. Family histories for basal cell carcinoma and xeroderma pigmentosum were negative. Classical features of Gorlin's syndrome were conspicuous by their absence. Histopathologically, the tumors revealed typical findings of basal cell carcinoma arising from actinic keratoses. The case in point is a very rare and unique case in itself as being nonsyndromic, nonhereditary and occurring in the absence of various other environmental conditions as already mentioned in literature.
Solitary Fibrous Tumor Presenting as a Parapharyngeal Mass
Authors: Pankaj Chaturvedi , Prathamesh Pai , Goregaonkar Ruta , Viswanathan Seethalakshmi , Kane SV 
Published: March 2010

AbstractSolitary fibrous tumors (SFT) rarely occur in the neck region and can be easily mistaken for more common tumors if the index of suspicion is not high. They are characterized by remarkable histologic variability. However, immunopositivity for CD34 and Bcl2 with immunonegativity for other markers aid in establishing the diagnosis. Distinction from the other common benign entities is essential, as SFT are tumors of low grade aggressiveness and unpredictable biologic behavior. Complete resection is the key feature determining outcome.