bluuebunny/crossref_metadata_2025_split huggingface dataset:
Low‐cost ultra‐wideband discrete SPDT switch for K–Ku band in automotive applications and fifth‐generation systems
Authors: Bakhshi Mehran , Faramarzi Vahid , Akbari Mahmood 
Published: April 2024

AbstractThe article details the development and production of an ultra‐wideband discrete single‐pole‐double‐throw (SPDT) Switch, measuring , and functioning within the 23.4–31 GHz frequency range, encompassing 24 and 28 GHz. This switch is specifically engineered to bolster high‐frequency systems in automotive and fifth‐generation applications. Our findings demonstrate that the discrete SPDT switch performs on par with integrated circuits while delivering consistent performance throughout its frequency spectrum. Furthermore, it offers a cost‐effective fabrication process. The switch exhibits an insertion loss ranging from 1.6 to 2.2 dB, with return loss and isolation surpassing 15 and 25 dB, respectively, across the majority of the frequency bandwidths.
Patient trust, quality communication, and medication adherence in rheumatoid arthritis patients highly affected by social determinants of health
Authors: Salt Elizabeth , Wiggins Amanda T. , Francis Diane , Lohr Kristine , Rayens Mary Kay 
Published: April 2024

AbstractIntroductionBecause medication adherence is essential to the management of rheumatoid arthritis (RA), identifying (1) subgroups at high risk for low medication adherence and (2) modifiable factors potentially contributing to low adherence can impact patient outcomes. This study aims to describe the relationships between anxiety, trust in the provider, quality patient‐provider communication, fatigue, RA knowledge, adverse medication effects, disease activity, RA medications, disease duration, patient satisfaction, and medication intolerance and cluster factors to differentiate RA‐patient subgroups.MethodsThis observational study used correlation analysis, linear regression, and cluster analysis with determination decisions based on Schwarz's Bayesian Criterion.ResultsMedication adherence was higher in non‐Hispanic, White participants, inversely correlated with disease activity and pain intensity, and positively correlated with trust in the provider. Patient satisfaction was higher among those with a shorter time since diagnosis, and was negatively associated with disease activity, pain intensity and interference, fatigue, and anxiety. It was positively associated with RA knowledge, trust in provider and quality of patient‐provider communication. Medication intolerance differed by disease duration and was positively correlated with disease activity, pain interference, and fatigue. Of the two clusters, Cluster 1 participants had greater medication adherence and patient satisfaction, and lower medication intolerance. They were of higher income, employed, and non‐Hispanic, White persons with a shorter disease duration and lower perceived pain intensity/interference, fatigue, and anxiety. They were more knowledgeable about RA with higher trust in their provider and perceived quality of patient‐provider communication.Discussion/conclusionA low medication adherence RA‐patient subgroup‐highly affected by social determinants of health and with unique relational and clinical characteristics was identified.
First Bite Syndrome in Transoral Surgery for Oropharyngeal Cancer
Authors: Wistermayer Paul R. , Brown Adam E. , Cave Taylor B. , Klusovsky Laura E. , Chang Brent A. , Hayden Richard E. , Hinni Michael L. , McGary Alyssa , Nagel Thomas H. 
Published: April 2024

AbstractObjectiveFirst bite syndrome (FBS) is a rare complication of transoral surgery (TOS) for oropharyngeal cancer (oropharyngeal squamous cell carcinoma [OPSCC]). Risk factors for developing this complication are not well described. In this study, we attempt to identify risks for developing FBS in TOS.Study DesignRetrospective chart review.SettingTertiary care medical center.MethodsThis study was exempted by the Mayo Clinic institutional review board. We performed a review from January 2017 to November 2022 of all patients who underwent TOS for OPSCC by a single provider. Exclusion criteria included less than 6 months follow up, prior treatment of head and neck cancer, or incomplete records. Demographic data, comorbidities, tumor characteristics, surgical details, adjuvant treatment details, functional outcomes, and oncologic outcomes were assessed. Fisher's Exact test and Kruskal‐Wallis rank sum test were used to identify significant variables, and multivariable logistic regression was used to address confounding.ResultsOne hundred and one patients were identified. Eighty‐nine met the inclusion criteria. The mean follow‐up was 34 months (median 33). Seven patients (7.9%) developed FBS. Palatine tumor primary (P = .041), resection of styloglossus/stylopharyngeus (P = .039), and parapharyngeal fat manipulation (P = .015) were associated with the presence of FBS. After adjusting for tumor location, manipulation of parapharyngeal fat maintained significance (P = .025). T and N staging, tumor volume, adjuvant radiation, and ligation of lingual/facial arteries were not associated with the development of FBS. Eighty‐six percent (6/7) of patients had a resolution of FBS at an average of 11.3 months.ConclusionManipulation of the parapharyngeal space is independently associated with developing FBS in TOS in our cohort. Further confirmatory studies are warranted.
Loss of Independence in Older Adults With Operable Oral Cavity Cancer: A Retrospective Cohort Study
Authors: Le Blanc Gabriella , Richardson Keith , Mlynarek Alex , Hier Michael P. , Sadeghi Nader , Kergoat Marie‐Jeanne , Mascarella Marco 
Published: April 2024

AbstractObjectiveTo ascertain the effect of curative‐intent surgery on loss of independence (LOI) in patients with oral cavity squamous cell carcinoma (OCSCC).Study DesignRetrospective observational study of patients diagnosed from 2014 to 2021.SettingSingle tertiary care academic center. Patients having undergone curative‐intent surgical treatment for OCSCC from 2014 to 2021 in the cancer registry.MethodsLOI as the primary outcome was measured based on a combination of decrease in activities of daily living (ADLs) and/or decline in mobility during treatment. Descriptive statistics were used to compare baseline demographics and multivariable logistic regression was used to assess the association between LOI and perioperative variables of interest.ResultsOf the 180 patients included in this study, 139 (79%) were fully independent in ADLs/instrumental ADLs prior to surgery. The average age of the cohort was 74 with 49% males. Thirty‐seven (21%) experienced a decline in mobility or increased care needs following surgery, and 18 (10%) experienced an independent decline in functional status. Increasing age, osseous flap reconstruction, high Charlson Comorbidity Index, and major postoperative adverse events were associated with LOI. Fifty‐five percent of patients with LOI had recovered to baseline within 7 months from surgery. LOI was associated with poor treatment tolerance (odds ratio: 4.77, 95% confidence interval: 1.87‐12.2) while adjusting for multiple confounders.ConclusionLOI is common in older adults undergoing curative‐intent surgery for OCSCC and associated with poor treatment tolerance.
Relationship of Nocturnal Insomnia Symptoms and Outcomes After Hypoglossal Nerve Stimulation
Authors: Dhanda Patil Reena , Suurna Maria V. , Steffen Armin , Soose Ryan , Coxe James , Chan Teresa , Ishman Stacey L. 
Published: April 2024

AbstractObjectiveIn patients undergoing hypoglossal nerve stimulation (HGNS), we examined the Insomnia Severity Index (ISI) to understand how baseline sleep onset insomnia (SOI), sleep maintenance insomnia (SMI), and early morning awakening (EMA) affected postsurgical outcomes.Study DesignObservational.SettingMulticenter registry.MethodsWe included patients from the Adherence and Outcomes of Upper Airway Stimulation for Obstructive Sleep Apnea International Registry (ADHERE) with a baseline ISI from 2020 to 2023. Regression analysis examined the association of ISI question scores for SOI, SMI, and EMA and outcomes: Apnea‐Hypopnea Index (AHI) reduction, device usage, changes in the Epworth Sleepiness Scale (ESS) and overall ISI score, final visit (FV) completion, and satisfaction.ResultsNo relationship was noted between insomnia subtypes and AHI reduction or FV completion. In the subgroup of patients with baseline moderate/severe insomnia, patients with major impairment for SOI used their device 64 min/day longer than those with minimal impairment. Among all patients, those with baseline major impairment for SOI had a 2.3 points greater improvement in ISI from baseline to FV compared to patients with minimal impairment, while patients with baseline major impairment for SMI had a 2.0 and 3.5 points greater improvement in the ESS and ISI than those with minimal impairment. Patients with EMA and moderate/severe baseline insomnia had decreased odds of being satisfied after surgery.ConclusionIn ADHERE, nocturnal symptoms of insomnia did not limit HGNS efficacy or therapy use. Conversely, those with worse insomnia subtype impairments at baseline had improved outcomes related to adherence, sleepiness, and insomnia at the FV.
Cardiac adaptation and malformation in twin–twin transfusion syndrome and selective fetal growth restriction: A systematic review
Authors: Noll Anne T. R. , Gijtenbeek Manon , Verweij E. J. T (Joanne) , Lewi Liesbeth , Herling Lotta , Haak Monique C. 
Published: April 2024

AbstractObjectivesThis systematic review explores cardiac adaptation in monochorionic (MC) twins with twin–twin transfusion syndrome (TTTS) or selective fetal growth restriction (sFGR) and assesses the risk of congenital heart defects (CHDs).MethodsAdhering to PRISMA guidelines, 63 studies were reviewed (49 on cardiac adaptation, 13 on CHD, one on both). A narrative synthesis of cardiac adaptation patterns was performed. Additionally, a meta‐analysis compared the livebirth prevalence of CHD in TTTS and sFGR against uncomplicated MC twins.ResultsIn TTTS recipients, cardiac function may be impaired for diastolic, systolic, as well as global functions, while in donors, cardiac function is generally preserved. In sFGR, large twins may show hypertrophic cardiomyopathy, and small twins may show impaired systolic function. Co‐occurrence of TTTS and sFGR magnifies cardiac impact but is often underreported. Meta‐analysis for CHD prevalence revealed a relative risk ratio of 3.5 (95% CI: 2.5–4.9) for TTTS and 2.2 (95%CI: 1.3–3.5) for sFGR compared with uncomplicated MC twins.ConclusionsThis study highlights the well‐documented cardiac adaptation in TTTS, contrasting with limited understanding in sFGR. Elevated CHD risks were observed in both conditions. Enhanced cardiovascular surveillance is warranted in complicated MC twin pregnancies. Future research should explore cardiac adaptation in sFGR and its long‐term consequences.
Perinatal outcomes of fetoscopic selective laser photocoagulation for spontaneous twin‐anemia polycythemia sequence
Authors: Munoz Jessian L. , Buskmiller Cara , Sanz Cortes Magdalena , Donepudi Roopali V. , Belfort Michael A. , Nassr Ahmed A. 
Published: April 2024

AbstractObjectivesAntenatal management of monochorionic pregnancies complicated by twin anemia polycythemia sequence (TAPS) remains sub‐optimally defined. Our objective was to evaluate the safety and efficacy of fetoscopic selective laser photocoagulation with respect to fetal and neonatal survival.MethodsA case series is reported with patients referred to the Texas Children's Fetal Center for evaluation and management of suspected spontaneous TAPS without concomitant twin‐to‐twin syndrome from 2014 to 2023. All evaluations were performed by our team and patients with stage II‐IV TAPS were offered expectant management, intrauterine transfusion, or laser therapy. Cases of post‐laser TAPS were excluded from this study. Pregnancy and neonatal outcomes were obtained from electronic medical records.ResultsDuring a 10‐year time period, 18 patients presented to our center for the management of TAPS. Thirteen patients had stage II–IV TAPS (13/18, 72%) and elected to proceed with laser photocoagulation. All procedures were completed, and “solomonization” was performed for 12/13. Normalization of middle cerebral artery Dopplers in both fetuses was noted after all cases. There was one intrauterine fetal death of the 26 viable fetuses after laser treatment, which was complicated by selective growth restriction. Most patients (12/13) were delivered by Cesarean section at a mean gestational age of 29 ± 3 weeks. Subsequently, there was one ex‐donor neonatal death in an infant who had prenatal hydrops. Overall, 30‐day postnatal survival was 24/26 fetuses (92.3%).ConclusionsIn the setting of spontaneous TAPS, laser therapy is feasible and appears to be an effective approach with overall favorable perinatal outcomes.
Designer‐Supraleiter nehmen Form an
Authors: Wagner Glenn , Soldini Martina O. , Küster Felix , Sessi Paolo , Parkin Stuart , Neupert Titus 
Published: April 2024

ZusammenfassungEs ist uns gelungen, neue Designer‐Supraleiter Atom für Atom aufzubauen. Dazu nutzten wir ein Rastertunnelmikroskop, um Chromatome auf einer Niob‐Oberfläche gezielt in einem zweidimensionalen Gitter anzuordnen. Durch die magnetischen Chromatome entstehen dabei Quantenzustände, die in der supraleitenden Bandlücke des Niobs liegen. Es zeigte sich, dass diese sogenannten Yu‐Shiba‐Rusinov‐Zustände einen eigenen supraleitenden Zustand bilden können. Dessen Eigenschaften hängen von der geometrischen Anordnung der Chromatome ab. Theoretische Berechnungen und Messungen mit dem Rastertunnelmikroskop deuten darauf hin, dass es sich um einen zweidimensionalen topologischen Supraleiter handelt. Solche topologischen Supraleiter würden sich für wesentlich robustere Quantencomputer eignen.
Model fusion for predicting unconventional proteins secreted by exosomes using deep learning
Authors: Zhang Yonglin , Yu Lezheng , Yang Ming , Han Bin , Luo Jiesi , Jing Runyu 
Published: April 2024

AbstractUnconventional secretory proteins (USPs) are vital for cell‐to‐cell communication and are necessary for proper physiological processes. Unlike classical proteins that follow the conventional secretory pathway via the Golgi apparatus, these proteins are released using unconventional pathways. The primary modes of secretion for USPs are exosomes and ectosomes, which originate from the endoplasmic reticulum. Accurate and rapid identification of exosome‐mediated secretory proteins is crucial for gaining valuable insights into the regulation of non‐classical protein secretion and intercellular communication, as well as for the advancement of novel therapeutic approaches. Although computational methods based on amino acid sequence prediction exist for predicting unconventional proteins secreted by exosomes (UPSEs), they suffer from significant limitations in terms of algorithmic accuracy. In this study, we propose a novel approach to predict UPSEs by combining multiple deep learning models that incorporate both protein sequences and evolutionary information. Our approach utilizes a convolutional neural network (CNN) to extract protein sequence information, while various densely connected neural networks (DNNs) are employed to capture evolutionary conservation patterns.By combining six distinct deep learning models, we have created a superior framework that surpasses previous approaches, achieving an ACC score of 77.46% and an MCC score of 0.5406 on an independent test dataset.
Review of predicting protein stability changes upon variations
Authors: Qiu Yiling , Huang Tao , Cai Yu‐Dong 
Published: April 2024

AbstractForecasting alterations in protein stability caused by variations holds immense importance. Improving the thermal stability of proteins is important for biomedical and industrial applications. This review discusses the latest methods for predicting the effects of mutations on protein stability, databases containing protein mutations and thermodynamic parameters, and experimental techniques for efficiently assessing protein stability in high‐throughput settings. Various publicly available databases for protein stability prediction are introduced. Furthermore, state‐of‐the‐art computational approaches for anticipating protein stability changes due to variants are reviewed. Each method's types of features, base algorithm, and prediction results are also detailed. Additionally, some experimental approaches for verifying the prediction results of computational methods are introduced. Finally, the review summarizes the progress and challenges of protein stability prediction and discusses potential models for future research directions.
Inorganic photochromic materials: Recent advances, mechanism, and emerging applications
Authors: Du Jiaren , Yang Zetian , Lin Hengwei , Poelman Dirk 
Published: April 2024

AbstractInorganic photochromic materials, as emerging photoresponsive materials, have attracted unparalleled interest because of their potential applications in various photoactive devices such as smart windows, optical memories, and photochromic decorations. Over the past decades, great research efforts have been focused on further development of high‐performance photochromic materials, revealing the underlying physical mechanism as well as exploring new advanced applications. However, significant challenges still exist in achieving large photochromic contrast, realizing color‐tunable response, and confirming the detailed photochromic processes. In this review, the latest progress of inorganic photochromic materials is summarized from the aspects of the advance of new materials, the mechanism of photochromism, the techniques for evaluating and revealing photochromism, and the methods for regulating photochromic behavior. The emerging applications of photochromic materials for optical information storage, photocatalysis, optical anti‐counterfeiting, radiation dosimetry and so on are also discussed. The perspectives and challenges of photochromic materials in terms of practical applications are presented. This review aims to provide fundamentals about the mechanism, properties and applications of inorganic photochromic materials and promote the application of photochromic materials in various optical devices.
Evaluation of soil water content and bulk electrical conductivity across the U.S. Climate Reference Network using two electromagnetic sensors
Authors: Wilson Timothy B. , Kochendorfer John , Diamond Howard J. , Meyers Tilden P. , Hall Mark , Lee Temple R. , Saylor Rick D. , Krishnan Praveena , Leeper Ronald D. , Palecki Michael A. 
Published: April 2024

AbstractSoil bulk electrical conductivity (BEC) was evaluated alongside soil volumetric water content (VWC) and soil temperature measurements using the HydraProbe (model HydraProbe, Stevens Water Monitoring Systems, Inc.) (hereafter called HP) with accuracy range of BEC ≤ 0.3 S m−1, and the time domain reflectometry (TDR)‐315L Probe (model TDR‐315L, Acclima, Inc.) (hereafter called AP) suitable for BEC up to 0.6 S m−1, at 23 stations of the U.S. Climate Reference Network. Previous evaluations revealed inconsistent performance of both sensors in some clay soils using manufacturer‐recommended calibrations in converting dielectric permittivity measurements to VWC. Here, we found that hourly values of BEC reached 0.6 S m−1 in high clay content soils and exceeded 2 S m−1 in high saline soils, and these high values of BEC were associated with poor performance and failures of both HP and AP sensors. Large values of BEC occurred in predominantly saturated soils where VWC values reached about 0.5 m3 m−3 for saline soils and about 0.7 m3 m−3 for clay soils, while low magnitudes of BEC were associated with low soil water content and seldomly saturated soils. Low hourly BEC values of less than 0.1 S m−1 were observed in wide variety of soil types, where sensor performance was typically excellent. The most influential factor on BEC was high soil water content conditions. Although dielectric permittivity measurements in estimating the soil water content were sensitive to BEC as some high clay content and high salinity soils increased BEC, the impact of large BEC on dielectric permittivity measurements was smaller in the well‐drained top soil layers than in deep soil layers that remained near saturation. Soil temperature had only a small impact on BEC. With high clay content and high salinity, the specific area of clay minerals was also associated with the magnitude of BEC.
Small kinetic mixing in string theory
Authors: Hebecker Arthur , Jaeckel Joerg , Kuespert Ruben 
Published: April 2024

Abstract
Kinetic mixing between gauge fields of different U(1) factors is a well-studied phenomenon in 4d EFT. In string compactifications with U(1)s from sequestered D-brane sectors, kinetic mixing becomes a key target for the UV prediction of a phenomenologically important EFT operator. Surprisingly, in many cases kinetic mixing is absent due to a non-trivial cancellation. In particular, D3-D3 kinetic mixing in type-IIB vanishes while D3-anti-D3 mixing does not. This follows both from exact CFT calculations on tori as well as from a leading-order 10d supergravity analysis, where the key cancellation is between the C2 and B2 contribution. We take the latter approach, which is the only one available in realistic Calabi-Yau settings, to a higher level of precision by including sub-leading terms of the brane action and allowing for non-vanishing C0. The exact cancellation persists, which we argue to be the result of $${\text{SL}}\left(2,{\mathbb{R}}\right)$$ self-duality. We note that a B2C2 term on the D3-brane, which is often missing in the recent literature, is essential to obtain the correct zero result. Finally, allowing for $${\text{SL}}\left(2,{\mathbb{R}}\right)$$-breaking fluxes, kinetic mixing between D3-branes arises at a volume-suppressed level. We provide basic explicit formulae, both for kinetic as well as magnetic mixing, leaving the study of phenomenologically relevant, more complex situations for the future. We also note that describing our result in 4d supergravity appears to require higher-derivative terms — an issue which deserves further study.
The role of absorption terms in Dirichlet problems for the prescribed mean curvature equation
Authors: Oliva Francescantonio , Petitta Francesco , Segura de León Sergio 
Published: April 2024

AbstractIn this paper we study existence and uniqueness of solutions to Dirichlet problems as $$\begin{aligned} {\left\{ \begin{array}{ll} g(u) \displaystyle -{\text {div}}\left( \frac{D u}{\sqrt{1+|D u|^2}}\right) = f &{} \text {in}\;\Omega ,\\ u=0 &{} \text {on}\;\partial \Omega , \end{array}\right. } \end{aligned}$$

g

(
u
)

-
div

Du

1
+

|
D
u
|

2

=
f

in

Ω
,

u
=
0

on

∂
Ω
,

where $$\Omega $$
Ω
is an open bounded subset of $${{\,\mathrm{\mathbb {R}}\,}}^N$$

R

N

($$N\ge 2$$

N
≥
2

) with Lipschitz boundary, $$g:\mathbb {R}\rightarrow \mathbb {R}$$

g
:
R
→
R

is a continuous function and f belongs to some Lebesgue space. In particular, under suitable saturation and sign assumptions, we explore the regularizing effect given by the absorption term g(u) in order to get solutions for data f merely belonging to $$L^1(\Omega )$$

L
1

(
Ω
)

and with no smallness assumptions on the norm. We also prove a sharp boundedness result for data in $$L^{N}(\Omega )$$

L
N

(
Ω
)

as well as uniqueness if g is increasing.