bluuebunny/crossref_metadata_2025_split huggingface dataset:
Enhanced expressions of apelin on proliferative hepatic arterial capillaries in human cirrhotic liver
Authors: Yokomori Hiroaki , Oda Masaya , Yoshimura Kazunori , Hibi Toshifumi 
Published: April 2012

Aim:  Apelin (APLN), the endogenous ligand of angiotensin‐like receptor 1 (APJ), is a peptide necessary for embryonic and tumor angiogenesis. Little is known about the localization and changes of APLN expression including the sinusoids in human cirrhotic liver, which might contribute to portal hypertension. This study was designed to elucidate the localization and change of APLN expression in human liver during the progression of cirrhosis.Methods:  Twelve normal liver specimens, eight specimens of Child–Pugh grade A cirrhosis, and 10 specimens of Child–Pugh grade C cirrhosis were studied. APLN protein and gene expression was examined by immunohistochemistry, western blotting, immunoelectronic microscopy, and laser captured microdissection (LCM) followed by polymerase chain reaction (PCR) in sinusoid.Results:  In control liver tissue, APLN was localized mainly on arterial endothelial cells and hepatic arterioles in the portal tract. In cirrhotic liver tissue, aberrant APLN expression was observed in periportal capillary endothelial cells corresponding to capillarized sinusoids, and in proliferated arterial capillaries in the fibrotic septa. Significant overexpression of APLN at protein level in cirrhotic liver was demonstrated by western blotting (P < 0.01 Child–Pugh A and C versus control, P < 0.01 Child–Pugh A versus C). APLN mRNA expression in the sinusoid was confirmed by LCM‐PCR.Conclusion:  In humans, APLN protein and gene were overexpressed in cirrhotic liver compared with normal liver, and the magnitude increased as cirrhosis progressed. Especially in end‐stage cirrhosis, APLN was strongly expressed in proliferated arterial capillaries directly connected with the sinusoids, suggesting a role of APLN in the proliferation of arterial capillaries in cirrhosis.
Eliciting cues to deception by tactical disclosure of evidence: The first test of the Evidence Framing Matrix
Authors: Granhag Pär Anders , Strömwall Leif A. , Willén Rebecca M. , Hartwig Maria 
Published: April 2012

Purpose. Research on real‐life suspect interviews shows that disclosure of evidence is a very common tactic and that it occurs in all phases of the interview. It is therefore remarkable that there is hardly any research on the effectiveness of different disclosure tactics. The aim of this study was to examine the effects of three different disclosure tactics: presenting the evidence early and two versions of the Strategic Use of Evidence (SUE) technique.Methods. For the SUE‐Basic technique (SUE‐B), the evidence was disclosed late in the interview. For the SUE‐Incremental technique (SUE‐I), we used a stepwise disclosure tactic derived from the so‐called Evidence Framing Matrix. The tactic consists of revealing evidence of increasing strength and precision. A mock‐theft scenario was employed with 195 participants who were randomly allocated to one of six conditions: guilty or innocent suspects were interviewed with one of the three techniques. Two measures of inconsistency were used as dependent variables: statement‐evidence inconsistency and the newly developed within‐statement inconsistency.Results. By interviewing with SUE‐I, strong cues to deception were elicited, especially for the statement‐evidence inconsistency variable. For the SUE‐B, significant but smaller differences between guilty and innocent suspects were obtained.Conclusions. We found that both when and how the evidence was disclosed moderated the effectiveness of disclosure. With respect to when, it was more effective to disclose the evidence late (vs. early), and with respect to how, it was more effective to disclose the evidence in a stepwise (vs. direct) manner. The tactical aspects of evidence disclosure are discussed.
Alternative Archaeology: Many Pasts in Our Present
Authors: Andersson Pia 
Published: April 2012

Abstract
This article introduces the field of alternative archaeology. After a short presentation of how the field has been received by professional archaeologists, different ways of defining it are discussed, and potential demarcations are examined. A survey of the most frequently discussed topics follows, together with a discussion of the methodologies employed and the theoretical presuppositions accepted by writers in the alternative archaeology genre, and how these differ from the methods and theories of conventional academic archaeology. A brief section on the relevance of alternative archaeology to the study of religion concludes the article.
Bernhard von Clairvaux, Robert von Melun und die Anfänge des mittelalterlichen Voluntarismus
Authors: Perkams Matthias 
Published: April 2012

Abstract
Two distinguishing marks of voluntaristic conceptions of human action can be found already in the 12th century, not only in the work of Bonaventura’s successors: 1. the will is free to act against reasons’s dictates; 2. moral responsibility depends on this conception of the will’s freedom. A number of theologians from the 1130s to the 1170s accepted those claims, which have been originally formulated by Bernard of Clairvaux. Robert of Melun elaborated them in a systematical way and coined the terminological distinctions which were controversely discussed in the following centuries. The paper edits and interprets some of his texts about voluntary action. Furthermore, it shows that Bernard’s and Robert’s ideas have been transported by their intellectualist critics in the 13th century.
Professional Lobbying in Eighteenth-century Brussels: The Role of Agents in Petitioning the Central Government Institutions in the Habsburg Netherlands
Authors: Vermeesch Griet 
Published: April 2012

Abstract
Historians have underscored the crucial importance of petitions both in early modern political practice and for relations between rulers and ruled. However, little is known about how formal requests were actually presented to rulers or the role of professional lobbyists. This article describes these individuals, using materials from a well-documented case, namely the court agents who were active in recommending petitions to the central government councils in eighteenth-century Brussels. Via these officially appointed lobbyists, citizens could obtain access to central figures in the decision-making process and express their personal grievances, desires and needs. This article argues that the efforts which court agents had to exert in order to present and recommend such petitions hint at the time- and money-consuming nature of petitioning. Court agents were supposed to offer their services free of charge to poor people, but opportunities for petitioning were in all probability less open to households of modest means. On the other hand, the court agents surely broadened the opportunities for petitioning in general, as—in exchange for a fee—anyone could draw on their expertise and contacts in government circles so as to be heard. Although patronage remained highly important throughout the eighteenth century, government accessibility increased in a more egalitarian manner, due to the work of these agents.
Copper Plates for the Qianlong Emperor: from Paris to Peking via Canton
Authors: Newby Laura 
Published: April 2012

Abstract
In the early 1760s, Jesuit missionaries serving as court artists in Peking were instructed by the Qianlong emperor (r. 1736-96) to produce a set of sixteen sketches in celebration of his recent victories over the Mongols and the Turkic Muslims in the region of present-day Xinjiang. The designs that were to be engraved on copper plates and printed in Europe were dispatched from Canton to Paris where the work was executed. Yet it was not until 1777, over a decade after the Qianlong emperor had initiated the project that his order was fully realized and the sixteen original designs, the sixteen copper plates, and 200 prints drawn from each plate, had all arrived in Beijing. This paper explores the politics behind the execution of this unique set of prints.
Who Needs Effective Doha Negotiations, and Why?
Authors: Andersson Erik 
Published: April 2012

Abstract
The growth and resilience of world trade indicate that the original aim of the General Agreement on Tariffs and Trade (GATT) has been largely fulfilled. This success makes the economic interest of parties in the Doha Development Round (DDR) less clear. This article analyzes how countries express their interests in the Doha round, based on their reactions to the breakdown in Geneva in July 2008. A qualitative analysis of these reactions reveals that the interests of the actors differ considerably. Only a minority of the member countries express an interest in negotiations congruent with the Ricardian logic of the original mandate of GATT and the WTO. The interests of other parties seem to be furthered by stalling negotiations. An increasingly important dimension of the DDR is the negotiation and institutionalization of norms, but this dimension hitherto has not been overtly handled. Unless they are productively dealt with, this difference in actors’ interests, and the opaque negotiation of norms, will decrease the effectiveness of the Doha negotiations.
A Universal Procedural Framework for War Crimes Tribunals
Authors: Okebukola Elijah Oluwatoyin 
Published: April 2012

Abstract
Notwithstanding the uniformity of war crimes substantive law, applicable procedural rules vary from jurisdiction to jurisdiction. In the case of ad hoc tribunals, the applicable rules may not be known until the tribunal is established. Consequently, there is uncertainty and incoherence in war crimes procedural law. Furthermore, the quality of applicable rules is dependent on the varying experience, knowledge and intentions of the framers of the procedural rules of each tribunal. This article makes the case for a universal procedural framework that can serve as an instrument for evaluating and creating war crimes procedural rules. Amongst other things, such a framework will bring about certainty and coherence in war crimes procedural law. In devising the model framework, the article adopts the Benthamite approach to the relationship between substantive law and procedural law and also relies on some aspects of the process evaluation theories of Robert Summers and Michael Bayles.
The Topography of Historical Contingency
Authors: Inkpen Rob , Turner Derek 
Published: April 2012

Abstract
Starting with Ben-Menahem’s definition of historical contingency as sensitivity to variations in initial conditions, we suggest that historical events and processes can be thought of as forming a complex landscape of contingency and necessity. We suggest three different ways of extending and elaborating Ben-Menahem’s concepts: (1) By supplementing them with a notion of historical disturbance; (2) by pointing out that contingency and necessity are subject to scaling effects; (3) by showing how degrees of contingency/necessity can change over time. We also argue that further development of Sterelny’s notion of conditional inevitability leads to our conclusion that the topography of historical contingency is something that can change over time.
Three Rival Views of Tradition (Arendt, Oakeshott and MacIntyre)
Authors: Alexander James 
Published: April 2012

Abstract
If we define tradition too hastily we leave to one side the question of what the relevance of tradition is for us. Here the concept of tradition is opened up by considering the different views of it taken by Hannah Arendt, Michael Oakeshott and Alasdair MacIntyre. We see that each has put tradition into a fully developed picture of what our predicament is in modernity; and that each has differed in their assessment of what our relation to tradition is or should be. Arendt sees tradition as something which no longer conditions action, Oakeshott sees tradition as something which conditions all action, and MacIntyre sees tradition as something which should condition right action. In each case, the view of tradition is clearly one element in an attempt to see how the most important constituent elements of human existence – variously called the human condition, human conduct, or human virtue – should be understood in a modernity which is ours because it has put the traditional concept of tradition into question.
Collingwood’s Opposition to Biography
Authors: Kindi Vasso 
Published: April 2012

Abstract
Biography is usually distinguished from history and, in comparison, looked down upon. R. G. Collingwood’s view of biography seems to fit this statement considering that he says it has only gossip-value and that “history it can never be”. His main concern is that biography exploits and arouses emotions which he excludes from the domain of history. In the paper I will try to show that one can salvage a more positive view of biography from within Collingwood’s work and claim that his explicit attacks against biography target specifically the sensationalist kind. First, I will show that Collingwood, in his later writings, allowed that, not only thought, but also relevant emotions can be the subject matter of history, which means that even if one takes biography to deal with emotions, it can still qualify as history. Second, I will argue, based mainly on Collingwood’s Principles of Art, that biography can be compared to portrait painting, in which case, it can be redeemed as a work of art and not just craft and, thus, have more than entertainment value. It can also be part of history, and more specifically part of the history of art which Collingwood endorses, if one takes the life of an individual, recounted by a biographer, to be an artistic creation, as Collingwood seems to suggest.
Vertical Structure of Tropical Cyclone Rainbands as Seen by the TRMM Precipitation Radar
Authors: Hence Deanna A. , Houze Robert A. 
Published: April 2012

AbstractTen years of data from the Tropical Rainfall Measurement Mission satellite’s Precipitation Radar (TRMM PR) show the vertical structure of tropical cyclone rainbands. Radar-echo statistics show that rainbands have a two-layered structure, with distinct modes separated by the melting layer. The ice layer is a combination of particles imported from the eyewall and ice left aloft as convective cells collapse. This layering is most pronounced in the inner region of the storm, and the layering is enhanced by storm strength. The inner-region rainbands are vertically confined by outflow from the eyewall but nevertheless are a combination of strong embedded convective cells and robust stratiform precipitation, both of which become more pronounced in stronger cyclones.Changes in rainband coverage, vertical structure, and the amount of active convection indicate a change in the nature of rainbands between the regions inward and outward of a radius of approximately 200 km. Beyond this radius, rainbands consist of more sparsely distributed precipitation that is more convective in nature than that of the inner-region rainbands, and the outer-region rainband structures are relatively insensitive to changes in storm intensity. The rainbands in both inner and outer regions are organized with respect to the environmental wind shear vector. The right-of-shear quadrants contain newer convection while in the left-of-shear quadrants the radar echoes are predominantly stratiform. This asymmetric distribution of rainband structures strengthens with environmental wind shear. Cool sea surfaces discourage rainband convection uniformly.
Atmospheric Forcing of Antarctic Sea Ice on Intraseasonal Time Scales
Authors: Renwick James A. , Kohout Alison , Dean Sam 
Published: April 2012

Abstract
Intraseasonal relationships between Antarctic sea ice and atmospheric circulation have been investigated using a 29-yr record of pentad-mean Antarctic sea ice concentration and Southern Hemisphere 500-hPa height fields. Analyses were carried out for four sea ice seasons: minimum extent, growth, maximum extent, and decay. Interannual variability was removed from both datasets to focus on intraseasonal variations. Patterns of sea ice variability and linkages to the atmospheric circulation varied markedly with season. The strongest and most coherent relationships were evident during the maximum ice extent period and to a lesser degree during the growth period. At those times of year, the strongest relationships were associated with atmospheric circulation anomalies leading sea ice anomalies by 4 or 5 days, suggesting that variations in the atmospheric circulation force changes in the sea ice field. Ice decreases are generally found in regions of poleward flow and ice increases are found in regions of equatorward flow. Mechanisms appear to be related both to thermal advection and to mechanical forcing, with the relative importance of each varying in space and in time. During the period of maximum ice extent, the leading pattern from a maximum covariance analysis between 500-hPa height and sea ice concentration accounted for 38% of the squared covariance between fields, and the associated time series were correlated at 0.74. The leading patterns of variability exhibit clear zonal wavenumber 3 signatures and appear to be largely a result of internal variability in the extratropical circulation.
Improving the Prediction of the East Asian Summer Monsoon: New Approaches
Authors: Fan Ke , Liu Ying , Chen HuoPo 
Published: April 2012

Abstract
East Asian summer monsoon (EASM) prediction is difficult because of the summer monsoon’s weak and unstable linkage with El Niño–Southern Oscillation (ENSO) interdecadal variability and its complicated association with high-latitude processes. Two statistical prediction schemes were developed to include the interannual increment approach to improve the seasonal prediction of the EASM’s strength. The schemes were applied to three models [i.e., the Centre National de Recherches Météorologiques (CNRM), the Met Office (UKMO), and the European Centre for Medium-Range Weather Forecasts (ECMWF)] and the Multimodel Ensemble (MME) from the Development of a European Multimodel Ensemble System for Seasonal-to-Interannual Prediction (DEMETER) results for 1961–2001. The inability of the three dynamical models to reproduce the weakened East Asian monsoon at the end of the 1970s leads to low prediction ability for the interannual variability of the EASM. Therefore, the interannual increment prediction approach was applied to overcome this issue. Scheme I contained the EASM in the form of year-to-year increments as a predictor that is derived from the direct outputs of the models. Scheme II contained two predictors: both the EASM and also the western North Pacific circulation in the form of year-to-year increments. Both the cross-validation test and the independent hindcast experiments showed that the two prediction schemes have a much better prediction ability for the EASM than does the original scheme. This study provides an efficient approach for predicting the EASM.
Transcriptomic and proteomic analyses of Desulfovibrio vulgaris biofilms: Carbon and energy flow contribute to the distinct biofilm growth state
Authors: Clark Melinda E , He Zhili , Redding Alyssa M , Joachimiak Marcin P , Keasling Jay D , Zhou Jizhong Z , Arkin Adam P , Mukhopadhyay Aindrila , Fields Matthew W 
Published: April 2012

Abstract

Background

Desulfovibrio vulgaris Hildenborough is a sulfate-reducing bacterium (SRB) that is intensively studied in the context of metal corrosion and heavy-metal bioremediation, and SRB populations are commonly observed in pipe and subsurface environments as surface-associated populations. In order to elucidate physiological changes associated with biofilm growth at both the transcript and protein level, transcriptomic and proteomic analyses were done on mature biofilm cells and compared to both batch and reactor planktonic populations. The biofilms were cultivated with lactate and sulfate in a continuously fed biofilm reactor, and compared to both batch and reactor planktonic populations.

Results
The functional genomic analysis demonstrated that biofilm cells were different compared to planktonic cells, and the majority of altered abundances for genes and proteins were annotated as hypothetical (unknown function), energy conservation, amino acid metabolism, and signal transduction. Genes and proteins that showed similar trends in detected levels were particularly involved in energy conservation such as increases in an annotated ech hydrogenase, formate dehydrogenase, pyruvate:ferredoxin oxidoreductase, and rnf oxidoreductase, and the biofilm cells had elevated formate dehydrogenase activity. Several other hydrogenases and formate dehydrogenases also showed an increased protein level, while decreased transcript and protein levels were observed for putative coo hydrogenase as well as a lactate permease and hyp hydrogenases for biofilm cells. Genes annotated for amino acid synthesis and nitrogen utilization were also predominant changers within the biofilm state. Ribosomal transcripts and proteins were notably decreased within the biofilm cells compared to exponential-phase cells but were not as low as levels observed in planktonic, stationary-phase cells. Several putative, extracellular proteins (DVU1012, 1545) were also detected in the extracellular fraction from biofilm cells.

Conclusions
Even though both the planktonic and biofilm cells were oxidizing lactate and reducing sulfate, the biofilm cells were physiologically distinct compared to planktonic growth states due to altered abundances of genes/proteins involved in carbon/energy flow and extracellular structures. In addition, average expression values for multiple rRNA transcripts and respiratory activity measurements indicated that biofilm cells were metabolically more similar to exponential-phase cells although biofilm cells are structured differently. The characterization of physiological advantages and constraints of the biofilm growth state for sulfate-reducing bacteria will provide insight into bioremediation applications as well as microbially-induced metal corrosion.