bluuebunny/crossref_metadata_2025_split huggingface dataset:
ChemInform Abstract: A Green One‐Pot Multicomponent Synthesis of 4H‐Pyrans and Polysubstituted Aniline Derivatives of Biological, Pharmacological, and Optical Applications Using Silica Nanoparticles as Reusable Catalyst.
Authors: Banerjee Subhash , Horn Alissa , Khatri Hari , Sereda Grigoriy 
Published: July 2011

AbstractThe three‐component reaction of 1,3‐diketo compounds with aldehydes and malononitrile provides 4H‐pyrans in high yields.
ChemInform Abstract: Design and Synthesis of 3‐(3‐Chloro‐4‐substituted phenyl)‐4‐(pyridine‐4‐yl)‐1H‐pyrazole‐1‐carboxamide Derivatives and Their Antiproliferative Activity Against Melanoma Cell Line.
Authors: El‐Gamal Mohammed I. , Oh Chang‐Hyun 
Published: July 2011

Abstract3,4‐Diarylpyrazole derivatives possessing an amide moiety at C‐1 of the pyrazole ring are synthesized and screened for their antiproliferative activity against A375 human melanoma cell line.
ChemInform Abstract: The Preparation of Ketene Dithioacetals and Thiophenes from Chloropyridines Containing an Active Methylene Group.
Authors: Sturrock Keith R. , Bremner David H. , Wishart Grant 
Published: July 2011

AbstractThe base‐catalyzed abstraction of the methylene protons of chloropyridines (I) and the subsequent formation of a ketene dithioacetal dianion leads to, upon alkylation followed by treatment with sodium ethoxide, formation of thiophenes (V) and (VI), probably via a Thorpe‐type cyclization.
ChemInform Abstract: Reversible Dehydrogenation—Hydrogenation of Tetrahydroquinoline‐Quinoline Using a Supported Copper Nanoparticle Catalyst.
Authors: Mikami Yusuke , Ebata Kaori , Mitsudome Takato , Mizugaki Tomoo , Jitsukawa Koichiro , Kaneda Kiyotomi 
Published: July 2011

AbstractTitania‐supported copper nanoparticles act as a heterogeneous catalyst for the reversible dehydrogenation and hydrogenation of tetrahydroquinoline/quinoline under an atmospheric pressure of hydrogen.This reversible organic hydride system can be applied under mild conditions and repeated with retention of high efficiency.
ChemInform Abstract: Preparation of New Nitrogen‐Bridged Heterocycles. Part 71. A New Synthetic Approach to Some Functionalized Cycl[3.2.2]azine Derivatives.
Authors: Muranaka Hideyuki , Kakehi Akikazu , Suga Hiroyuki , Itoh Kennosuke 
Published: July 2011

AbstractFunctionalized cyclazine derivatives (VI) are obtained by dehydrogenation of dihydrothiazinoindolizine derivatives (III) and (IV) in low to moderate yields.
ChemInform Abstract: Design, Synthesis and in vitro Antimicrobial Evaluation of Novel Imidazo[1,2‐a]pyridine and Imidazol[2,1‐b][1,3]benzothiazole Motifs.
Authors: Al‐Tel Taleb H. , Al‐Qawasmeh Raed A. , Zaarour Rania 
Published: July 2011

AbstractCompared to control antibiotics amoxicillin, cefixime and fluconazole, newly synthesized compounds (III), (V), and (IX) exert strong inhibition of several bacterial and fungal strains.
ChemInform Abstract: Controlling Site Selectivity in Pd‐Catalyzed Oxidative Cross‐Coupling Reactions.
Authors: Lyons Thomas W. , Hull Kami L. , Sanford Melanie S. 
Published: July 2011

AbstractThis paper describes studies that address the factors controlling site selectivity in the Pd‐mediated oxidative coupling of 1,3‐disubstituted and 1,2,3‐trisubstituted arenes.
ChemInform Abstract: Novel Dihydropyrimidines and Its Pyrazole Derivatives: Synthesis and Pharmacological Screening.
Authors: Ramesh B. , Bhalgat Chetan M. 
Published: July 2011

AbstractDihydropyrimidines (I) and (II) and pyrazole derivatives (IV) are screened in vitro for their antioxidant, anti‐inflammatory, antibacterial, antifungal, and anthelmintic activity.
ChemInform Abstract: Synthesis and Biological Evaluation of Pyrido(2,3‐d)pyrimidine‐carboxylate Derivatives.
Authors: Shanmugasundaram P. , Harikrishnan N. , Aanandini M. Vijey , Kumar M. Sathish , Sateesh J. N. 
Published: July 2011

AbstractSix new pyridopyrimidinecarboxylate derivatives (XI) and (XIV) are synthesized, which all show significant antibacterial, antifungal and antitumor activities.
ChemInform Abstract: Eco‐Friendly Solventless Synthesis of 5‐Indolylpyrimido[4,5‐d]pyrimidinones and Their Antimicrobial Activity.
Authors: Gupta Ragini , Jain Anshu , Joshi Rahul , Jain Meenakshi 
Published: July 2011

AbstractThe title compounds (IV) are conveniently obtained in a multi‐component reaction under microwave irradiation in dry media or using the grindstone technology.
ChemInform Abstract: Structure—Activity Relationships of New N‐Acylanthranilic Acid Derivatives as Plasminogen Activator Inhibitor‐1 Inhibitors.
Authors: Yamaoka Nagahisa , Kodama Hidehiko , Izuhara Yuko , Miyata Toshio , Meguro Kanji 
Published: July 2011

AbstractNew N‐acylanthranilic acid derivatives such as (I) are designed, synthesized and evaluated for their in vitro plasminogen activator inhibitory activities.
ChemInform Abstract: Novel Benzimidazo[2,1‐c][1,4]thiazinone Derivatives with Potent Activity Against HSV‐1.
Authors: Galal Shadia A. , El‐Naem Shweekar I. , El‐Nezhawy Ahmed O. H. , Ali Mohamed A. , El‐Diwani Hoda I. 
Published: July 2011

AbstractAll compounds are tested for their activity against the herpes simplex virus 1.
ChemInform Abstract: Facile One‐Pot Synthesis of Novel 3‐Substituted‐1,6‐dihydro‐1,2,4‐triazin‐5‐(2H)‐ones from Fatty Acid Hydrazides and Their in vitro Antimicrobial Activity.
Authors: Farshori Nida Nayyar , Banday Mudasir Rashid , Ahmad Anis , Khan Asad Ullah , Rauf Abdul 
Published: July 2011

AbstractThe new triazine derivatives (III) show moderate to good antibacterial and antifungal activities.
ChemInform Abstract: Design and Synthesis of Potent and Selective Aldose Reductase Inhibitors Based on Pyridylthiadiazine Scaffold.
Authors: Zhu Changjin , et al. et al. 
Published: July 2011

AbstractSeveral newly synthesized pyrido[2,3‐e]‐[1,2,4]thiadiazine 1,1‐dioxide derivatives (VII) are found to be potent aldose reductase inhibitors with compound (VIId) exhibiting the highest activity.
ChemInform Abstract: A Microwave‐Assisted Diastereoselective Multicomponent Reaction to Access Dibenzo[c,e]azepinones. Synthesis and Biological Evaluation.
Authors: Mehta Vaibhav P. , Modha Sachin G. , Ruijter Eelco , Van Hecke Kristof , Van Meervelt Luc , Pannecouque Christophe , Balzarini Jan , Orru Romano V. A. , Van der Eycken Erik 
Published: July 2011

AbstractThe reaction allows efficient and diastereoselective formation of dibenzoazepinones of type (IV).
ChemInform Abstract: Chemistry of a Geminal Frustrated Lewis Pair Featuring Electron Withdrawing C6F5 Substituents at Both Phosphorus and Boron.
Authors: Stute Annika , Kehr Gerald , Froehlich Roland , Erker Gerhard 
Published: July 2011

AbstractThe phosphine borane (I) represents a new frustrated Lewis pair (FLP) with a decreased Lewis basicity on the phosphorus atom.
ChemInform Abstract: Synthesis of Selenohydantoins from Isoselenocyanates and α‐Amino Acids.
Authors: Maeda Hajime , Sakata Koichi , Takashima Masaru , Watanabe Tatsuya , Mizukami Nobuteru , Honda Mitsunori , Segi Masahito 
Published: July 2011

AbstractSelenohydantoins (III) and (V) are obtained by reaction of isoselenocyanates (I) with α‐amino acids (II) and (IV), resp.
ChemInform Abstract: Phloroglucinols from the Leaves of Eucalyptus globulus.
Authors: Kawabata Tetsuro , Hasegawa Tatsuya , Nojiri Yuka , Uchida Chiaki , Tsubata Tomoyuki , Kato Hikaru , Takano Fumihide , Ohta Tomihisa 
Published: July 2011

AbstractEuglobal‐IX (I), a new acylphloroglucinol sesquiterpene, inhibits the catalytic activity of CYP3A4.
ChemInform Abstract: α,α‐Dichloroisoxazolidinones for the Synthesis and Chemoselective Peptide Ligation of α‐Peptide α‐Ketoacids.
Authors: Narumi Tetsuo , Bode Jeffrey W. 
Published: July 2011

AbstractThe present study is directed towards the preparation of enantiomerically enriched α,α‐dichloroisoxazolidinones and their use for the iterative synthesis of α‐oligopeptides.
ChemInform Abstract: Synthesis of a Chiral C3‐Symmetric Bowl‐Shaped Cyclohexapeptide Composed of Anthranilic Acid and Leucine.
Authors: Akazome Motohiro , Enzu Masashi , Goto Yohei , Matsumoto Shoji 
Published: July 2011

AbstractThe cyclic hexapeptide (I) is synthesized from 2‐nitrobenzoic acid and leucine via coupling of three dipeptide intermediates.
ChemInform Abstract: Monosaccharide as a Central Scaffold Toward the Construction of Salicylate‐Based Bidentate PTP1B Inhibitors via Click Chemistry.
Authors: Tang Yan‐Hui , Hu Min , He Xiao‐Peng , Fahnbulleh Sando , Li Cui , Gao Li‐Xin , Sheng Li , Tang Yun , Li Jia , Chen Guo‐Rong 
Published: July 2011

AbstractA series of bidentate triazolyl glucosides bearing two salicylic precursors on 2,6‐, 3,4‐, 4,6‐, and 2,3‐ position of the central glucosyl scaffold is prepared via click chemistry as key step.
ChemInform Abstract: Tricalysionoside A, a Megastigmane Gentiobioside, Sulfatricalysines A—F, and Tricalysiosides X—Z, ent‐Kaurane Glucosides, from the Leaves of Tricalysia dubia
Authors: Shitamoto Junko , Sugimoto Sachiko , Matsunami Katsuyoshi , Otsuka Hideaki , Shinzato Takakazu , Takeda Yoshio 
Published: July 2011

Abstractisolation and structural elucidation of one new megastigmane gentiobioside, tricalysionoside A (I), three sulfates, sulfatricalysines A‐C and three new ent‐kaurane glucosides such as tricalysioside Z (II)
ChemInform Abstract: Convenient Synthesis of the Key Intermediate for Dihydrocorynantheol and Protoemetinol from the Monoacetate of 4‐Cyclopentene‐1,3‐diol.
Authors: Kobayashi Yuichi , Yagi Kaori , Kaneko Yuki 
Published: July 2011

AbstractStereoselective installation of two side chains affords the key lactone (VI) in a 60% overall yield from monoacetate (I).
ChemInform Abstract: Two Novel Benzastatin Derivatives, JBIR‐67 and JBIR‐73, Isolated from Streptomyces sp. RI18.
Authors: Motohashi Keiichiro , Nagai Aya , Takagi Motoki , Shin‐ya Kazuo 
Published: July 2011

AbstractThe new benzastatin derivatives, JBIR‐67 (I) and JBIR‐73 (II) show weak cytotoxicity against human cervical carcinoma HeLa cell lines.
ChemInform Abstract: Resveratrol Dimers with an Oxabicyclo Ring in Vatica albiramis.
Authors: Abe Naohito , Ito Tetsuro , Oyama Masayoshi , Sawa Ryuichi , Takahashi Yoshikazu , Iinuma Munekazu 
Published: July 2011

AbstractAlbiraminol C (Ia), D (IIb) and vatalbinosides G (Ib), H (Ic), I (IIa), and J (III) are isolated from the stem of the title plant.
ChemInform Abstract: An Efficient Synthesis of Antibiotic SF‐2312 (3‐Dihydroxyphosphoryl‐1,5‐dihydroxy‐2‐pyrrolidone).
Authors: Hanaya Tadashi , Itoh Chika 
Published: July 2011

AbstractThe synthesis of the title antibiotic (VII) is performed as a preliminary study for the asymmetric synthesis of (VII).
ChemInform Abstract: Synthesis and Antibacterial Activity of New 4′′‐O‐Carbamates of 11,12‐Cyclic Carbonate Erythromycin A 6,9‐Imino Ether.
Authors: Zhang Ling , Jiao Bo , Yang Xiangrui , Liu Lin , Ma Shutao 
Published: July 2011

AbstractAll target compounds (I) show potent activities against erythromycin‐susceptible S.pneumoniae comparable to erythromycin A, clarithromycin and azithromycin, Additionally, the new imino ethers exhibit improved activities against erythromycin‐resistant S.pneumoniae B1 and AB11 compared with erythromycin A and azithromycin.
ChemInform Abstract: Reinvestigation of the Structure of Monensin A Phenylurethane Sodium Salt Based on X‐Ray Crystallographic and Spectroscopic Studies, and Its Activity Against Hospital Strains of Methicillin‐Resistant S. epidermidis and S. aureus.
Authors: Huczynski Adam , Ratajczak‐Sitarz Malgorzata , Stefanska Joanna , Katrusiak Andrzej , Brzezinski Bogumil , Bartl Franz 
Published: July 2011

AbstractX‐ray data of crystals of monensin A phenylurethane sodium salt (I) shows that the compound forms a pseudocyclic structure, stabilized by three intramolecular hydrogen bonds and the sodium cation coordinated by five oxygen atoms in the hydrophilic sphere.
ChemInform Abstract: A Cyclic Acetal Tethered Intramolecular Diels—Alder Cycloaddition. Studies Directed Toward a Total Synthesis of (.+‐.)‐Fusidilactone C.
Authors: Ghosh Sunil K. , Wei Yonggang , Gerasyuto Aleksey I. , Feltenberger John B. , Wang Jiashi , Hsung Richard P. 
Published: July 2011

AbstractCycloaddition precursor (I) allows a facile and unique intramolecular Diels—Alder cycloaddition, proceeding highly endo‐selective to provide the endo‐I and endo‐II products (II) and (III).
ChemInform Abstract: Polymyrifline A, a New Polymethoxyflavone from Citrus aurantium var. myrtifolia.
Authors: Hirasawa Yusuke , Hirata Mari , Haruna Katsuya , Takeda Masahiro , Ogawa Kazunori , Morita Hiroshi 
Published: July 2011

AbstractPolymyrifline A (I) is isolated from the peels of the title plant together with known polymethoxy flavones.
ChemInform Abstract: Isolation and Structure Elucidation of Izuminosides A—C: A Rare Phenazine Glycosides from Streptomyces sp. IFM 11260.
Authors: Abdelfattah Mohamed S. , Toume Kazufumi , Ishibashi Masami 
Published: July 2011

AbstractThree new glycosylated phenazine derivatives, izuminosides A‐C (I), are isolated and evaluated for their activities in overcoming tumor necrosis factor‐related apoptosis‐inducing ligand (TRAIL) resistance in human gastric adenocarcinoma cells.
ChemInform Abstract: Crystal to Crystal Transformations and Polymorphism in Anionic Hydrogen Bonding Networks Stabilized by Crown Ether Metal Complexes
Authors: Braga Dario , D'Agostino Simone , Grepioni Fabrizia , Gandolfi Massimo , Rubini Katia 
Published: July 2011

AbstractReview: 79 refs.
ChemInform Abstract: Developing Pyrrole‐Derived Antimycobacterial Agents: A Rational Lead Optimization Approach
Authors: Biava Mariangela , Porretta Giulio Cesare , Poce Giovanna , Battilocchio Claudio , Alfonso Salvatore , de Logu Alessandro , Manetti Fabrizio , Botta Maurizio 
Published: July 2011

AbstractReview: 36 refs.
Safety Devices and Disposal Systems for Multipurpose Plants. Part 1 – Safety Concept and Layer of Protection
Authors: Schmidt Jürgen , Stoessel Francis 
Published: July 2011

AbstractFeinchemikalien und Produkte der pharmazeutischen Industrie werden vorwiegend in Mehrzweckanlagen produziert. Charakteristisch sind viele Rezepturen und zahlreiche, zum Teil sehr unterschiedliche Prozesse. Die verfahrenstechnische Herausforderung besteht oft darin, ein bestimmtes Verfahren an eine gegebene Anlage anzupassen. Mit einer systematischen Risikoanalyse werden mögliche Gefahren und die Auslegungsszenarien identifiziert. Das Schutzkonzept der Anlage soll dabei nicht geändert werden. Sicherheits‐ und Rückhalteeinrichtungen müssen sorgfältig aufeinander abgestimmt sein und dürfen weder zu klein noch unzulässig groß bemessen sein. Ein durchgängiges Konzept für die Absicherung von Mehrzweckanlagen wird dargestellt. Beginnend bei der Identifikation von Gefahrenpotenzialen erfolgt eine Bewertung mithilfe von Kritikalitätsklassen. Die Auslegung eines Sicherheitsventil‐Abblasesystems nach dem Stand der Technik wird vorgestellt.
Synthesis of Hexanoic Acid in Supercritical Carbon Dioxide
Authors: Dahmen Nicolaus , Kruse Andrea , Wiegand Gabriele , Dinjus Eckhard 
Published: July 2011

AbstractAm Beispiel der vergleichsweise einfachen autokatalytischen, partiellen Oxidation von Hexanal zu Hexansäure konnten die Vorteile des Einsatzes von CO2 als Lösungsmittel erfolgreich herausgearbeitet werden und in eine Prozessentwicklung münden. Auf der Basis der ermittelten Stoff‐ und Reaktionsdaten wurde ein Prozessdesign erstellt und mittels einer Prozesssimulation Massen‐ und Energiebilanzen für eine Anlagenauslegung berechnet. Schließlich wurden die Kosten für die Herstellung von Hexansäure nach dem vorgeschlagenen Verfahren abgeschätzt.
Biosorption of Cd(II) and Zn(II) by Nostoc commune: Isotherm and Kinetics Studies
Authors: Morsy Fatthy M. , Hassan Sedky H. A. , Koutb Mostafa 
Published: July 2011

AbstractIn this study, Nostoc commune (cyanobacterium) was used as an inexpensive and efficient biosorbent for Cd(II) and Zn(II) removal from aqueous solutions. The effect of various physicochemical factors on Cd(II) and Zn(II) biosorption such as pH 2.0–7.0, initial metal concentration 0.0–300 mg/L and contact time 0–120 min were studied. Optimum pH for removal of Cd(II) and Zn(II) was 6.0, while the contact time was 30 min at room temperature. The nature of biosorbent and metal ion interaction was evaluated by infrared (IR) technique. IR analysis of bacterial biomass revealed the presence of amino, carboxyl, hydroxyl, and carbonyl groups, which are responsible for biosorption of Cd(II) and Zn (II). The maximum biosorption capacities for Cd(II) and Zn(II) biosorption by N. commune calculated from Langmuir biosorption isotherm were 126.32 and 115.41 mg/g, respectively. The biosorption isotherm for two biosorbents fitted well with Freundlich isotherm than Langmuir model with correlation coefficient (r2 < 0.99). The biosorption kinetic data were fitted well with the pseudo‐second‐order kinetic model. Thus, this study indicated that the N. commune is an efficient biosorbent for the removal of Cd(II) and Zn(II) from aqueous solutions.
Intrinsic properties guide proximal abducens and oculomotor nerve outgrowth in avian embryos
Authors: Lance‐Jones Cynthia , Shah Veeral , Noden Drew M. , Sours Emily 
Published: July 2011

AbstractProper movement of the vertebrate eye requires the formation of precisely patterned axonal connections linking cranial somatic motoneurons, located at defined positions in the ventral midbrain and hindbrain, with extraocular muscles. The aim of this research was to assess the relative contributions of intrinsic, population‐specific properties and extrinsic, outgrowth site‐specific cues during the early stages of abducens and oculomotor nerve development in avian embryos. This was accomplished by surgically transposing midbrain and caudal hindbrain segments, which had been pre‐labeled by electroporation with an EGFP construct. Graft‐derived EGFP+ oculomotor axons entering a hindbrain microenvironment often mimicked an abducens initial pathway and coursed cranially. Similarly, some EGFP+ abducens axons entering a midbrain microenvironment mimicked an oculomotor initial pathway and coursed ventrally. Many but not all of these axons subsequently projected to extraocular muscles that they would not normally innervate. Strikingly, EGFP+ axons also took initial paths atypical for their new location. Upon exiting from a hindbrain position, most EGFP+ oculomotor axons actually coursed ventrally and joined host branchiomotor nerves, whose neurons share molecular features with oculomotor neurons. Similarly, upon exiting from a midbrain position, some EGFP+ abducens axons turned caudally, elongated parallel to the brainstem, and contacted the lateral rectus muscle, their originally correct target. These data reveal an interplay between intrinsic properties that are unique to oculomotor and abducens populations and shared ability to recognize and respond to extrinsic directional cues. The former play a prominent role in initial pathway choices, whereas the latter appear more instructive during subsequent directional choices. © 2011 Wiley Periodicals, Inc. Develop Neurobiol 72: 167–185, 2012
Role of the maguk protein family in synapse formation and function
Authors: Oliva Carlos , Escobedo Pía , Astorga César , Molina Claudia , Sierralta Jimena 
Published: July 2011

AbstractSynaptic function is crucially dependent on the spatial organization of the presynaptic and postsynaptic apparatuses and the juxtaposition of both membrane compartments. This precise arrangement is achieved by a protein network at the submembrane region of each cell that is built around scaffold proteins. The membrane‐associated guanylate kinase (MAGUK) family of proteins is a widely expressed and well‐conserved group of proteins that plays an essential role in the formation and regulation of this scaffolding. Here, we review general features of this protein family, focusing on the discs large and calcium/calmodulin‐dependent serine protein kinase subfamilies of MAGUKs in the formation, function, and plasticity of synapses. © 2011 Wiley Periodicals, Inc. Develop Neurobiol 72: 57–72, 2012
Storage of CO2 hydrate in shallow gas reservoirs: pre‐ and post‐injection periods
Authors: Zatsepina Olga Ye , Pooladi‐Darvish Mehran 
Published: July 2011

AbstractWith the growing concern about climate change, interest in reducing CO2 emissions has increased. Geological storage of CO2 is perceived to be one of the most promising methods that could provide significant reductions in CO2 emissions over the short and medium term. Since a major concern regarding geological storage is the possibility of leakage, trapping CO2 in a solid form is quite attractive. Unlike mineral trapping, the kinetics of CO2‐hydrate formation is quite fast, providing the opportunity for long‐term storage of CO2.Thermodynamic calculations suggest that CO2 hydrate is stable at temperatures that occur in a number of formations in Northern Alberta, in an area where there are significant CO2 emissions associated with the production of oil sands and bitumen. In this paper, we study storage of CO2 in hydrate form at conditions similar to those at depleted gas pools in Northern Alberta. Our numerical simulation results show that the CO2 storage capacity of such pools is many times greater than their original gas‐in‐place. This provides a local option for storage of a portion of the CO2 emissions from the oil sands operations in northeastern Alberta.In an earlier paper, we studied hydrate formation during a period of continued CO2 injection. In this paper, we extend the duration of the investigation to include the period after injection has stopped. In particular, we study the storage capacity of such depleted gas pools and the fate of the hydrate over long periods of time when the injection of CO2 has slowed down or ceased. We examine the effect of properties of the reservoir and cap/base rocks, as well as operating conditions. In particular, we investigate a shut‐in case as the most realistic condition in CO2 field sequestration. © 2011 Society of Chemical Industry and John Wiley & Sons, Ltd