bluuebunny/crossref_metadata_2025_split huggingface dataset:
Modeling nerve conduction criteria for diagnosis of diabetic polyneuropathy
Authors: Dyck Peter J. , Carter Rickey E. , Litchy William J. 
Published: February 2011

AbstractIntroduction:In this study we aimed to determine which criteria are valid for nerve conduction (NC) diagnosis of typical diabetic sensorimotor polyneuropathy (DSPN).Methods:Eight criteria were assessed from among diabetes databases, the Rochester Diabetic Neuropathy Study (RDNS, N = 456), and in healthy subjects (RDNS‐HS, N = 330).Results:In the RDNS, the most frequent abnormal attributes (≤2.5th/≥97.5th percentile) are: fibular motor nerve conduction velocity (MNCV; 26.3%); sural sensory nerve conduction velocity (SNAP; 25.4%); tibial MNCV (24.8%); ulnar MNCV (21.3%); fibular F latency (16.9%); and ulnar F latency (16.0%). Normal deviate (from percentiles) composite scores of NC included: representative of neurophysiological abnormalities; sensitive and specific for diagnosis and useful for epidemiological surveys; randomized trials; and medical practice. By contrast, abnormality of one or more attributes in any nerve or abnormally of two most sensitive attributes performed poorly.Conclusions:Composite sum scores of normal deviates (from percentiles corrected for applicable variables) of sensitive NC attributes and with modifications, RDNS and AAN criteria performed acceptably for diagnosis of DSPN. Muscle Nerve 44: 340–345, 2011
Quality of life in complete spinal cord injury patients with a Brindley bladder stimulator compared to a matched control group
Authors: Martens Frank M.J. , den Hollander Philip P. , Snoek Govert J. , Koldewijn Evert L. , van Kerrebroeck Philip E.V.A. , Heesakkers John P.F.A. 
Published: February 2011

AbstractAims: To determine the effects on Quality of Life (QoL) of a Brindley procedure, which combines a sacral dorsal root rhizotomy to treat neurogenic detrusor overactivity with sacral anterior root stimulation to enable micturition, defecation, and penile erections in complete spinal cord injury (SCI) patients compared to a matched Control Group.Methods: Cross‐sectional study. The Qualiveen questionnaire, SF‐36 questionnaire, and multiple choice questions about urinary continence and urinary tract infections were sent to 93 patients who had a Brindley stimulator implanted in the Netherlands and a matched Control Group of 70 complete SCI patients with neurogenic detrusor overactivity. Primary study outcomes were Specific Impact of Urinary Problems score and general QoL index of the Qualiveen.Results: Response rates were 78% and 40% for patients with a Brindley stimulator and controls, respectively. Stimulators were still used for micturition in 46 (63%). These patients had a significant better Specific Impact of Urinary Problems score, general QoL index (Qualiveen), and continence rate, and less urinary tract infections compared to the Control Group. Patients also benefited of the rhizotomy with regard to QoL and continence rate if the stimulator was not used anymore. The subscales of the SF‐36 had better scores for the patients who used their stimulator as compared to those who did not use the stimulator and compared to the Control Group.Conclusions: The Brindley stimulator for complete spinal cord injury patients improves Quality of Life, continence, and urinary tract infection rate compared to a matched Control Group. 30:551–555, 2011. © 2011 Wiley‐Liss, Inc.
Hand grip and pinch strength in patients with nocturnal enuresis: Is there a role of muscle strength in pathogenesis of enuresis?
Authors: Karabiber Hamza , Garipardic Mesut , Uzel Murat , Davutoglu Mehmet , Ozer Ali , Hasturk Ziyadeddin , Guler Ekrem 
Published: February 2011

AbstractAimsTo examine the association of muscle strength with nocturnal enuresis.Subjects and MethodsOne hundred sixty‐three patients with monosymptomatic nocturnal enuresis (8–14 years old) were recruited from outpatient clinics. Two hundred eight healthy students served as the control group (8–14 years old) from two primary schools. Physical examinations and the age, gender, height, weight, dominant hand, and body mass of these children index were recorded. A calibrated, Jamar dynamometer was used to assess grip strength at the first two settings. A pinch gauge was used to assess the key pinch of the right and left hands of these children. Two measurements of each grip and pinch were obtained at 15 sec intervals and mean values were analyzed.ResultsThe hand grip strength test and pinch was significantly lower in the enuretic group compared with the control group. These low results of the muscle strength in the enuretic group showed that whole body muscle weakness may contribute to the pathogenesis of enuresis as a possible etiological factor.ConclusionsIn this first study on the association of muscle strength with nocturnal enuresis, it was found that neuromuscular function is abnormal in enuretic patients. In this neuromuscular abnormality, the motor activity is affected. 30:525–528, 2011. © 2011 Wiley‐Liss, Inc.
A new reconstruction procedure in central schemes for hyperbolic conservation laws
Authors: Balaguer‐Beser A. 
Published: February 2011

AbstractThis paper presents a new point value reconstruction algorithm based on average values or flux values for central Runge–Kutta schemes in the resolution of hyperbolic conservation laws. This reconstruction employs a fourth‐order accurate approximation of point values of the solution at the two extrema and at the mid‐point of each cell. These point values are modified in order to enforce monotonicity and shape preserving properties. This correction has been applied essentially in the cells close to the maxima and minima of the solution and in these cases, it has been proven that the reconstruction is fourth‐order accurate. In the cells with a maximum or minimum of the solution, a correction has also been applied to such point values with the aim of ensuring that the resulting numerical solution has a non‐oscillatory behavior. Several standard one‐ and two‐dimensional test cases are used to verify high‐order accuracy, non‐oscillatory behavior and high‐resolution properties for smooth and discontinuous solutions, and also in their componentwise extension to the Euler gas dynamics equations. Copyright © 2011 John Wiley & Sons, Ltd.
Delamination analysis of composites by new orthotropic bimaterial extended finite element method
Authors: Ashari S. Esna , Mohammadi S. 
Published: February 2011

AbstractThe extended finite element method (XFEM) is further improved for fracture analysis of composite laminates containing interlaminar delaminations. New set of bimaterial orthotropic enrichment functions are developed and utilized in XFEM analysis of linear‐elastic fracture mechanics of layered composites. Interlaminar crack‐tip enrichment functions are derived from analytical asymptotic displacement fields around a traction‐free interfacial crack. Also, heaviside and weak discontinuity enrichment functions are utilized in modeling discontinuous fields across interface cracks and bimaterial weak discontinuities, respectively. In this procedure, elements containing a crack‐tip or strong/weak discontinuities are not required to conform to those geometries. In addition, the same mesh can be used to analyze different interlaminar cracks or delamination propagation. The domain interaction integral approach is also adopted in order to numerically evaluate the mixed‐mode stress intensity factors. A number of benchmark tests are simulated to assess the performance of the proposed approach and the results are compared with available reference results. Copyright © 2011 John Wiley & Sons, Ltd.
Between‐group Differences in the Patterning of Musculo‐skeletal Stress Markers: Avoiding Confounding Factors by Focusing on Qualitative Aspects of Physical Activity
Authors: Stefanović S. , Porčić M. 
Published: February 2011

ABSTRACTThis paper presents a method for studying between‐group differences in physical activity patterns through the analysis of musculo‐skeletal stress markers (MSM). The specific aim was to develop a method that could overcome the problems related to confounding variables such as body size by shifting the analytical focus from the comparison of differences in intensity to the comparison of differences in kinds of activity. Instead of testing whether there are differences in the measures of central tendency of MSM scores between two groups, we proposed looking for differences in MSM covariation patterns. Formally, this is achieved through the statistical comparison of group‐specific MSM intercorrelation matrices. The null hypothesis is that the matrices are equal, and the statistical significance of the test statistic is obtained with a permutation test. In this way, the problem of confounding variables such as body size is mostly avoided because the procedure is based on the comparison of group‐specific sets of correlation coefficients which are scale‐free. The method was employed in a case study to investigate the differences in activity patterns between men and women from the Early Bronze Age population buried at the necropolis in Mokrin, Serbia. The null hypothesis of no difference between the male and female MSM correlation matrices was rejected (p = 0.0135). After the statistical significance of the difference was established, further investigation of male and female activity patterns was undertaken by means of principal component analysis (PCA) with varimax rotation. PCA results suggest that covariation between MSMs is stronger in the male sample. Success in demonstrating differences in activity patterns between sexes implies that the proposed method can be used to test for differences in physical activity between groups of individuals defined by criteria other than sex. Copyright © 2011 John Wiley & Sons, Ltd.
Maternal serum hCG, PAPP‐A and AFP as predictors of hemoglobin Bart disease at mid‐pregnancy
Authors: Tongprasert Fuanglada , Wanapirak Chanane , Tongsong Theera 
Published: February 2011

AbstractObjectiveTo evaluate the ability of maternal serum‐free β‐human chorionic gonadotrophin (β‐hCG), pregnancy‐associated plasma protein‐A (PAPP‐A), and alpha fetoprotein (AFP) levels in the screening of fetuses with hemoglobin (Hb) Bart's disease among pregnancies at risk.Materials and MethodsPregnancies at risk for fetal Hb Bart's disease scheduled for cordocentesis at 18 to 22 weeks were recruited into the study. Maternal serum‐free β‐hCG, PAPP‐A, and AFP concentrations were measured before cordocentesis, and the final fetal diagnosis of Hb Bart disease was based on fetal Hb typing using high‐performance liquid chromatography.ResultsOf 57 recruited pregnancies, 11 had fetal Hb Bart's disease and 46 were unaffected. Maternal serum alpha‐fetoprotein (MSAFP) concentrations were significantly higher in women with fetal Hb Bart's disease than those with unaffected fetuses (median 99.53 vs 50.83, P < 0.001), whereas the concentrations of free β‐hCG and PAPP‐A were not significantly different between the two groups (P = 0.543 and 0.777, respectively).ConclusionSecond‐trimester MSAFP may be clinically a useful screening test for fetal Hb Bart's disease among pregnancies at risk. Copyright © 2011 John Wiley & Sons, Ltd.
Reference ranges of fetal aortic and pulmonary valve diameter derived by STIC from 14 to 40 weeks of gestation
Authors: Tongprasert Fuanglada , Srisupundit Kasemsri , Luewan Suchaya , Sirichotiyakul Supatra , Piyamongkol Wirawit , Wanapirak Chanane , Tongsong Theera 
Published: February 2011

AbstractObjectiveTo develop reference ranges of fetal aortic and pulmonary valve diameter derived from volume datasets of spatio‐temporal image correlation (STIC).MethodsA cross‐sectional study was undertaken on low‐risk pregnancies with well‐established data from 14 to 40 weeks. Volume datasets of STIC were acquired for subsequent off‐line analysis. Aortic and pulmonary valve diameters were measured in STIC multiplanar view using 4D‐View version 9. Normal Z scores and centile reference ranges were constructed from these measurements against gestational age (GA) and biparietal diameter (BPD) as independent variables, using regression models for both mean and SD.ResultsA total of 606 volume datasets were successfully measured. Normal reference ranges for predicting mean values and SD of aortic and pulmonary valve diameter were constructed based on best‐fit equations (linear function) as follows: mean aortic diameter (mm) was modeled as a function of GA (weeks) and BPD (mm) as − 2.4838 + 0.2702× GA, (SD = 0.1482 + 0.0156× GA) and − 1.5952 + 0.0989× BPD (SD = 0.1672 + 0.00572× BPD). Mean pulmonary diameter was modeled as − 2.5924 + 0.2935× GA (SD = 0.2317 + 0.01524× GA) and − 1.6830 + 0.1083× BPD (SD = 0.1971 + 0.0059× BPD).ConclusionWe have provided nomograms and Z scores of fetal aortic and pulmonary valve diameters. These reference ranges may be a useful tool in the assessment of fetal cardiac abnormalities. Copyright © 2011 John Wiley & Sons, Ltd.
Phosphoproteome analysis of the pathogenic bacterium Helicobacter pylori reveals over‐representation of tyrosine phosphorylation and multiply phosphorylated proteins
Authors: Ge Ruiguang , Sun Xuesong , Xiao Chuanle , Yin Xingfeng , Shan Weiran , Chen Zhuo , He Qing‐Yu 
Published: February 2011

AbstractIncreasing evidence shows that protein phosphorylation on serine (Ser), threonine (Thr) and tyrosine (Tyr) residues is a major regulatory post‐translational modification in the bacteria. To reveal the phosphorylation state in the Gram‐negative pathogenic bacterium Helicobacter pylori, we carried out a global and site‐specific phosphoproteomic analysis based on TiO2‐phosphopeptide enrichment and high‐accuracy LC‐MS/MS determination. Eighty‐two phosphopeptides from 67 proteins were identified with 126 phosphorylation sites, among which 79 class I sites were determined to have a distribution of 42.8:38.7:18.5% for the Ser/Thr/Tyr phosphorylation, respectively. The H. pylori phosphoproteome is characterized by comparably big size, high ratio of Tyr phosphorylation, high abundance of multiple phosphorylation sites in individual phosphopeptides and over‐representation of membrane proteins. An interaction network covering 28 phosphoproteins was constructed with a total of 163 proteins centering on the major H. pylori virulence factor VacA, indicating that protein phosphorylation in H. pylori may be delicately controlled to regulate many aspects of the metabolic pathways and bacterial virulence.
Label‐free quantitative proteomics and SAINT analysis enable interactome mapping for the human Ser/Thr protein phosphatase 5
Authors: Skarra Dana V. , Goudreault Marilyn , Choi Hyungwon , Mullin Michael , Nesvizhskii Alexey I. , Gingras Anne‐Claude , Honkanen Richard E. 
Published: February 2011

AbstractAffinity purification coupled to mass spectrometry (AP‐MS) represents a powerful and proven approach for the analysis of protein–protein interactions. However, the detection of true interactions for proteins that are commonly considered background contaminants is currently a limitation of AP‐MS. Here using spectral counts and the new statistical tool, Significance Analysis of INTeractome (SAINT), true interaction between the serine/threonine protein phosphatase 5 (PP5) and a chaperonin, heat shock protein 90 (Hsp90), is discerned. Furthermore, we report and validate a new interaction between PP5 and an Hsp90 adaptor protein, stress‐induced phosphoprotein 1 (STIP1; HOP). Mutation of PP5, replacing key basic amino acids (K97A and R101A) in the tetratricopeptide repeat (TPR) region known to be necessary for the interactions with Hsp90, abolished both the known interaction of PP5 with cell division cycle 37 homolog and the novel interaction of PP5 with stress‐induced phosphoprotein 1. Taken together, the results presented demonstrate the usefulness of label‐free quantitative proteomics and statistical tools to discriminate between noise and true interactions, even for proteins normally considered as background contaminants.
Crystal structures of CmeR‐bile acid complexes from Campylobacter jejuni
Authors: Lei Hsiang‐Ting , Shen Zhangqi , Surana Priyanka , Routh Mathew D. , Su Chih‐Chia , Zhang Qijing , Yu Edward W. 
Published: February 2011

AbstractThe TetR family of transcription regulators are diverse proteins capable of sensing and responding to various structurally dissimilar antimicrobial agents. Upon detecting these agents, the regulators allow transcription of an appropriate array of resistance markers to counteract the deleterious compounds. Campylobacter jejuni CmeR is a pleiotropic regulator of multiple proteins, including the membrane‐bound multidrug efflux transporter CmeABC. CmeR represses the expression of CmeABC and is induced by bile acids, which are substrates of the CmeABC tripartite pump. The multiligand‐binding pocket of CmeR has been shown to be very extensive and consists of several positively charged and multiple aromatic amino acids. Here we describe the crystal structures of CmeR in complexes with the bile acids, taurocholate and cholate. Taurocholate and cholate are structurally related, differing by only the anionic charged group. However, these two ligands bind distinctly in the binding tunnel. Taurocholate spans the novel bile acid binding site adjacent to and without overlapping with the previously determined glycerol‐binding site. The anionic aminoethanesulfonate group of taurocholate is neutralized by a charge‐dipole interaction. Unlike taurocholate, cholate binds in an anti‐parallel orientation but occupies the same bile acid‐binding site. Its anionic pentanoate moiety makes a water‐mediated hydrogen bond with a cationic residue to neutralize the formal negative charge. These structures underscore the promiscuity of the multifaceted binding pocket of CmeR. The capacity of CmeR to recognize bile acids was confirmed using isothermal titration calorimetry and fluorescence polarization. The results revealed that the regulator binds these acids with dissociation constants in the micromolar region.
MOVPE growth and characterization of polar, semipolar and nonpolar InN on sapphire substrate
Authors: Moret Matthieu , Ruffenach Sandra , Briot Olivier , Gil Bernard 
Published: February 2011

AbstractWe have investigated the heteroepitaxy of indium nitride (InN) directly grown on nitridated sapphire substrates having different orientations. Growths were performed on C, A, M and R‐plane oriented sapphire in order to analyse the substrate orientation effect on the structural, optical and electronic properties of as‐grown InN. Atomic force microscopy imaging on the InN epilayers revealed different surface morphologies with crystallites well organized along a crystalline orientation of the layer. We have studied the structural anisotropy observed in these layers analysing high‐resolution X‐ray diffraction rocking curve experiments as a function of the in‐plane beam orientation. A‐plane oriented InN grown on R‐plane sapphire substrate shows a polarized photoluminescence anisotropy, with an anisotropy percentage of about 33%.
A theoretical study of HH σ bond activation catalyzed by VO2+ in gas phase
Authors: Chen Xiao‐Xia 
Published: February 2011

AbstractThe mechanism of HH σ bond activation catalyzed by VO(1A1/3A′) has been investigated by using density functional theory at the B3LYP/6‐311G(2d, p) level and the single‐point energy calculations were done at the CCSD/6‐311G (2d, p)//B3LYP/6‐311G(2d, p) level of theory using the geometries along the minimum energy pathway. According to our calculation results, the different reaction mechanisms were found for the singlet and triplet potential energy surfaces (PESs). Specially, the crossing points (CPs) between the different PESs have been located by means of the intrinsic reaction coordinate approach used by Yoshizawa et al, and corresponding minimum energy CPs that we obtained by the mathematical algorithm proposed by Harvey et al. has also been employed. In addition, the orbital interaction for ion‐molecule complexes 1IM1 and 3IM1 have been examined by fragment molecular orbital analysis. Finally, the frontier molecular orbital interaction analysis about 3TS1 and 3TS2 were used to gain useful information about the HH σ bond activation by VO. © 2011 Wiley Periodicals, Inc. Int J Quantum Chem, 2012
Two‐ and three‐state conical intersections in the electron capture dissociation of disulfides: The importance of multireference calculations
Authors: Gámez José A. , Serrano‐andrés Luis , Yáñez Manuel 
Published: February 2011

AbstractThe SS bond cleavage produced upon electron attachment to disulfides was generally assumed to be an adiabatic process because the added electron occupies the σ*(SS) antibonding orbital. This is clearly the case in the parent HSSH compound, but not necessarily in XSSX′ derivatives, where the substituents X and X′ are different. Through the use of MS‐CASPT2 calculations, we have shown that the dissociation of the SS two‐center‐three‐electron bond in these asymmetric XSSX′ compounds requires the interaction of at least two states, in order to localize the extra electron in one of the fragments upon dissociation. This is actually the case for the CH3SSNH2 derivative, where the most favorable dissociation process locates the extra electron at the SCH3 moiety, the SCH3· + SNH dissociation limit being 66 kJ mol−1 higher in energy. The situation is still more complex when one of the substituents is an OH group, because, in this particular case, the most favorable process is the dissociation of the SO rather than the SS bond. Besides, the two dissociation limits CH3SS· + OH− and CH3SS− + OH· are accidentally degenerate, so the SO bond fission involves a three‐state conical intersection. This constitutes the first example of a three‐state crossing computed by accurate ab initio calculations involved in a nonphotochemical reaction. These findings highlight the necessity of using multireference approaches to appropriately describe the electron capture dissociation of disulfide bridges. © 2011 Wiley Periodicals, Inc. Int J Quantum Chem 111: 3316–3323, 2011
Boundary effect on the adsorption properties of H2 on charged MgCaHb complex
Authors: Lei Hong‐Wen , Zhang Hong 
Published: February 2011

AbstractIn this article, the equilibrium structure, binding energy, and electronic structure for charged Mg coated CaHb (a = 6, b = 6; a = 14, b = 10; a = 22, b = 14; a = 24, b = 14; a = 54, b = 18) are investigated by using all electrons density‐functional calculations. The boundary effect for the adsorption property of H2 on charged MgCaHb complex is investigated by using several structures based on benzene ring molecules. A method for calculating the pathways for the synthesis of MgCaHbn+ is presented here, and also the kinetic stability of these charged hydrogen‐covered MgCaHbn+ complexes is also discussed. We find that the Mg doped complex with appropriate charge can enhance adsorption of hydrogen molecular. © 2011 Wiley Periodicals, Inc. Int J Quantum Chem, 2012