bluuebunny/crossref_metadata_2025_split huggingface dataset:
Morphological and molecular changes of oestrogen receptor‐positive breast cancer following bridging endocrine therapy: a United Kingdom multicentre study
Authors: Miligy Islam M , Awasthi Rachna , Mir Yasmeen , Khurana Anuj , Sharma Vijay , Chandaran Usha , Rakha Emad , Maurice Yasmine , Kearns Daniel , Oweis Rami , Asar Amal , Ironside Alastair , Shaaban Abeer M 
Published: June 2024

AimsStandard neoadjuvant endocrine therapy (NAET) is used for 6–9 months to downstage hormone‐receptor‐positive breast cancer. Bridging ET was introduced during the COVID‐19 pandemic to delay surgical intervention. There are no data in the literature on the effect of short course therapy on tumour response. We aimed to analyse the effect of bridging ET and validate the previously proposed neoadjuvant ET pathological reporting criteria.Methods and ResultsThis was a multicentre cohort of 256 patients who received bridging ET between March and October 2020. Assessment of paired pre‐ and post‐NAET hormone receptors and HER2 and posttherapy Ki67 expression was done. The median duration of NAET was 45 days. In all, 86% of cases achieved partial pathological response and 9% showed minimal residual disease. Histological response to ET was observed from as early as day 6 posttherapy. Central scarring was noted in 32.8% of cases and lymphocytic infiltrate was seen in 43.4% of cases. Significant changes associated with the duration of ET were observed in tumour grade (21%), with downgrading identified in 12% of tumours (P < 0.001), progesterone receptor (PR) expression with switch to PR‐negative status in 26% of cases (P < 0.001), and HER2 status with a switch from HER2‐low to HER2‐negative status in 32% of cases (P < 0.001). The median patient survival was 475 days, with an overall survival rate of 99.6%.ConclusionsChanges characteristic of tumour regression and significant changes in PR and HER2 occurred following a short course of NAET. The findings support biomarker testing on pretreatment core biopsies and retesting following therapy.
Disparities and barriers to the access of biologics in moderate‐to‐severe adult psoriasis
Authors: Wan Vincent , Habibi Alireza , Mija Lorena A. , Abdi Parsa , Selvakumar Rishika , Mukovozov Ilya 
Published: June 2024

AbstractPsoriasis is a chronic, relapsing inflammatory skin disorder that is associated with substantial physical and psychosocial comorbidity. Although biologic agents have offered transformative therapeutic advantages to those unresponsive to traditional treatments, data from recent literature indicate significant undertreatment of certain populations, highlighting potential barriers to access. This review aims to comprehensively elucidate barriers to biological therapy, addressing a recognized gap in the current literature. A search was conducted using MEDLINE, Embase, and Web of Science to investigate the obstacles and disparities that prevent access to biologic treatments in biologic‐naïve psoriatic patients. Emergent themes were then systematically categorized into five primary domains: patient‐level, prescriber‐level, medicine‐level, organizational‐, and external environment‐level factors. Our results demonstrate pronounced barriers and disparities encompassing increased age, race, socioeconomic status, rural location, cost and insurance, and insufficient knowledge that may hinder access to biologic treatments among psoriatic patients. Further research on how these barriers can be effectively addressed is needed to optimize treatment outcomes.
Loving and Letting: A Constructive Reading of Genesis 1
Authors: Olson J. W. 
Published: June 2024

AbstractThis essay evaluates possible meanings of God's creative ‘let’ in Genesis 1 in order to evaluate how God's generative love of creation forms a paradigm for human love. Beginning with the work of philosopher John Haugeland, who gives four possible meanings of letting‐be in his reading of Heidegger, this essay argues that creation is best understood in terms of Haugeland's model of letting‐be as enabling, in which what is created are conditions of possibility rather than determined outcomes. Understanding God's relationship to creation as making‐possible then sets the stage for characterizing right human relations as superabundantly generative rather than simply the absence of conflict.
The RNA interference response to alphanodavirus replication in Phlebotomus papatasi sand fly cells
Authors: Alexander Akira J. T. , Parry Rhys H. , Ratinier Maxime , Arnaud Frédérick , Kohl Alain 
Published: June 2024

AbstractIn this study, we identified and assembled a strain of American nodavirus (ANV) in the Phlebotomus papatasi‐derived PP9ad cell line. This strain most closely resembles Flock House virus and ANV identified in the Drosophila melanogaster S2/S2R cell line. Through small RNA sequencing and analysis, we demonstrate that ANV replication in PP9ad cells is primarily targeted by the exogenous small interfering RNA (exo‐siRNA) pathway, with minimal engagement from the PIWI‐interacting RNA (piRNA) pathway. In mosquitoes such as Aedes and Culex, the PIWI pathway is expanded and specialised, which actively limits virus replication. This is unlike in Drosophila spp., where the piRNA pathway does not restrict viral replication. In Lutzomyia sandflies (family Psychodidae), close relatives of Phlebotomus species and Drosophila, there appears to be an absence of virus‐derived piRNAs. To investigate whether this absence is due to a lack of PIWI pathway proteins, we analysed the piRNA and siRNA diversity and repertoire in PP9ad cells. Previous assemblies of P. papatasi genome (Ppap_1.0) have revealed a patchy repertoire of the siRNA and piRNA pathways. Our analysis of the updated P. papatasi genome (Ppap_2.1) has shown no PIWI protein expansion in sandflies. We found that both siRNA and piRNA pathways are transcriptionally active in PP9ad cells, with genomic mapping of small RNAs generating typical piRNA signatures. Our results suggest that the piRNA pathway may not respond to virus replication in these cells, but an antiviral response is mounted via the exo‐siRNA pathway.
Combinations of Energy‐based Devices plus isotretinoin for management of acne and acne scars: A systematic review
Authors: Xu Yidan , Wang Hao , Guo Linghong , Hamblin Michael R. , Wen Xiang 
Published: June 2024

AbstractBackground and ObjectiveA 6‐month interval between systemic isotretinoin (ISO) and the initiation of energy‐based interventions has been recommended, due to concerns about keloid formation and delayed wound healing. While this postponement goes against the current trend of early intervention for acne scarring. This systematic review evaluates the efficacy, safety, and patient satisfaction of combinations of ISO with energy‐based devices (EBD).Study Design/Methods and MaterialsPubMed, Embase, Web of Science, Cochrane Library, and Cochrane Central Register of Controlled Trials were comprehensively searched up to April 2023 according to PRISMA guidelines. Two independent reviewers screened the titles and abstracts to select articles. The quality of the literature was assessed for each study design.ResultsA total of 16 studies addressing the efficacy and safety of energy‐based modalities combined with ISO were identified, including six randomized controlled trials (RCTs), two case series, seven cohort studies, and one case report. ISO combinations with intense pulsed light (IPL), fractional ablative CO2 laser, pulsed dye laser (PDL), non‐ablative fractional laser (NAFL) and fractional microneedle radiofrequency (FMRF) have been tested for improving acne severity, acne scarring and erythema.ConclusionThe current evidence does not justify delaying the use of EBDs for patients who have recently undergone or are currently receiving ISO treatment. Evidence‐based treatments such as PDL, NAFL, and FMRF etc. are suggested relatively safe and effective in treating acne and acne scarring.
What is the Strategy of Strategy to Tackle Climate Change?
Authors: Wickert Christopher , Muzio Daniel 
Published: June 2024

AbstractTo effectively tackle climate change, the strategic management enterprise needs to fundamentally reinvent itself. In their Point, Bansal, Durand, Kreutzer, Kunisch and McGahan forcefully argue for such a turnaround and outline a ‘new strategy’ paradigm that integrates the constraints of planetary boundaries and Earth systems not as an afterthought, but as the basis of inquiry. This, however, doesn't come without fierce contestation, as shown by the Counterpoint by Foss and Klein and the further Counterpoint by Davis and DeWitt. In this introduction to the Point‐Counterpoint debate on strategic management and climate change, we argue that this contestation is largely due to what we call three epistemic fault lines that cut through how strategy scholars understand climate change, devise possible solutions, and assume the relationship between theories and reality. We specify these fault lines and connect them to important avenues for future research that expand the strategic management conversation about climate change.
Links between socioeconomic position and cognitive and behavioral regulation in adolescence: The role of pubertal development
Authors: Chaku Natasha , Waters Nicholas E. , Ahmed Sammy F. 
Published: June 2024

AbstractAdolescent cognitive and behavioral regulation is influenced by multidimensional and multidirectional processes within and across biological and contextual systems that shift throughout development. Key among these influences are distal processes such as early life socioeconomic position (SEP), and proximal processes such as pubertal development, but questions remain concerning how links between SEP, pubertal development, and cognitive and behavioral regulation accumulate and unfold over adolescence. In the current study, and in line with Dr. John Schulenberg's foundational work, direct associations between SEP, puberty, and adolescent cognitive and behavioral regulation were examined; then pubertal timing and tempo were considered as moderators and mediators of links between SEP and adolescent cognitive and behavioral regulation. Data were drawn from the NICHD Study of Early Child Care and Youth Development, a longitudinal study of 970 youth (52% male; 80% White, 13% Black, and 7% another race/ethnicity). Cognitive and behavioral regulation was measured using direct assessments of working memory, planning, risky decision‐making, and impulse control at age 15. SEP included maternal education and family income‐to‐needs and was averaged from birth to 54 months old; estimates of pubertal timing and tempo were derived using logistic growth curve models from age 9 to age 15. SEP was directly associated with cognitive and behavioral regulation. Pubertal development tended to moderate those links, but rarely mediated them. Specifically, socioeconomic disadvantage along with earlier timing or faster tempo tended to be associated with worse cognitive and behavioral regulation. Overall, findings suggest that pubertal timing and tempo may exacerbate existing environmental constraints.
Definition of refractory migraine and their evolution
Authors: Kikui Shoji , Danno Daisuke , Takeshima Takao 
Published: June 2024

AbstractIntroductionThe term ‘refractory migraine’ (RM) is commonly used in clinical settings; however, it is not recognized in the International Classification of Headache Disorders, third edition. A growing need for a shared definition of refractoriness has been highlighted by a multidisciplinary expert group. Although definitions for RM currently exist, the key parameters for the definition of refractoriness (e.g., unresponsiveness to treatment, high frequency, severe disability, or all of these features) remain contentious. Thus, a consensus on the definition of RM is crucial.MethodsCalcitonin gene‐related peptide (CGRP) is a neuropeptide that plays an important role in migraine pathophysiology and is a target for migraine preventive therapies. Monoclonal antibodies targeting the CGRP (i.e., galcanezumab, fremanezumab, and eptinezumab) and its receptor (erenumab) have shown consistent efficacy for migraine prophylaxis with excellent safety profiles. Their effect on refractory cases has also been reported, offering promise to the many patients who have not found relief with existing treatments. Therefore, we anticipate a paradigm shift in migraine treatment.ResultsFollowing the widespread use of monoclonal antibodies targeting the CGRP and its receptor, the European Headache Federation proposed a definition for two subsets of difficult‐to‐treat migraine—resistant and refractory migraine—that considers both the frequency and disability caused by single and frequent attacks.ConclusionWe expect that this definition will help resolve previous conflicts that have limited the use of earlier definitions.
H7 modulation of the L3 auditory neuron and phonotaxis in the cricket Acheta domesticus
Authors: Navia Benjamin , Widdicombe Lilly , Kim Lauren , Rim Jessica , Olivares Ana , Oster Zoe , Mbungu David 
Published: June 2024

AbstractSeveral studies have implicated the L3 auditory interneuron in the regulation of syllable period selective phonotaxis in female cricket Acheta domesticus. The L3's response to model calls of conspecific males comprises of an immediate and a prolonged response. The kinetics of activation of these electrical activities are consistent with sequential activation of ionotropic and metabotropic mechanisms. In this study, we used electrophysiological and pharmacological tools to investigate the cellular mechanisms underlying L3's response. Bath application of the synthetic protein kinase inhibitor 1‐(5‐isoquinolinesul‐fonyl)‐2‐methylpiperazine (H7), results in the suppression of L3's spiking response, and this effect can be reversed by saline wash. Additionally, when female A. domesticus that were previously nano‐injected with H7 were tested for phonotaxis on a non‐compensating treadmill, they demonstrated suppression of syllable period‐dependent phonotaxis. These findings implicate protein kinase in the regulation of L3's spiking rhythm and the associated phonotaxis in A. domesticus.
Danish citizens' perspectives on the preventive medication recommended after screen‐detected cardiovascular disease: A qualitative study
Authors: Højgaard Helen Gräs , Frederiksen Kirsten , Høgh Annete Langager , Rasmussen Bodil , Dahl Marie 
Published: June 2024

AbstractBackgroundThe rationale for screening for cardiovascular disease (CVD) is debated as a prevention strategy. However, research shows that when preventive medication is initiated after screening for CVD, mortality rates decrease, especially among men. When implementing screening programmes, facilitating citizens' informed decisions and empowering their autonomy in the decision‐making process are crucial. We therefore aimed to explore citizens' perspectives on and decisions regarding initiating cardiovascular preventive medication for screen‐detected CVD.MethodsWe employed an exploratory qualitative design using semi‐structured interviews to investigate participants' perspectives on and decisions regarding initiating cardiovascular preventive medication for screen‐detected CVD. Twelve interviews were conducted and analysed using thematic analysis following Braun and Clarke's six‐step approach.FindingsWe found one overall theme, Being on a continuum between wellness and illness, with two underlying sub‐themes. Sub‐theme (1) Navigating mixed feelings and pathways reflects participants' perspectives on CVD preventive medication, which were positioned on a continuum with shifting perspectives. The state between wellness and illness was experienced as liminal and characterised by uncertainty and concerns about CVD risk. (2) Navigating medication decisions: a negotiated process. Pivotal medical decisions hinged on trust in authorities or own judgement, influenced by attitudes towards the need for medication, perception of meaningfulness, asymptomatic condition, age, family responsibility and predisposition. Participants' medical decisions were supported and impacted by significant others.ConclusionWe uncovered a continuum of shifting perspectives ranging from feeling improved health to experiencing fear of CVD. For certain citizens, it is like navigating between these contrasting feelings. The perceived necessity and meaningfulness, in particular, shape medical decisions. Providing support for informed decisions is crucial and includes significant others. Shared decision‐making with healthcare professionals as facilitators is needed. Future research is warranted to investigate how to embrace the various perspectives on initiating CVD preventive medication in clinical practice.
The end of ambivalence. A narrative perspective on ambivalence in the suicidal process
Authors: Galasiński Dariusz , Ziółkowska Justyna 
Published: June 2024

AbstractIntroductionSuicidal ambivalence is a recognized phenomenon in suicidology, yet not much is known about it in the context of progression from suicidal ideation to action. The current study addresses this gap. We explore narrative dynamics of suicidal ambivalence in stories about transition from suicidal ideation to action.MethodsWe employ an experiential qualitative approach to gain in‐depth understanding of narrated experience of suicidal ambivalence. We conducted semi‐structured interviews with 22 patients hospitalized after a suicide attempt. For a detailed analysis, we selected 11 interviews in which the interviewees' accounts spontaneously referred to their ambivalence about attempting suicide. We used a text‐oriented version of Critical Discourse Studies (CDS) to analyze the semantics and syntax, as well as the functions of what was said within the local context, and the social actions thus accomplished.ResultsOur study shows primarily that ambivalence is not resolved. Rather, it is set aside and removed from the narrative and replaced by an action‐focused narrative with no references to mental activities.ConclusionWe propose that ambivalence recedes and gives way to action and that qualitative research provides a useful evidence base for conceptualizing and understanding the role of ambivalence in transition from suicidal ideation to action.
Introducing HESSS: Home Economics at Swiss Secondary Schools
Authors: Grob Anja , Binding Garret , Spirig Judith 
Published: June 2024

AbstractPolitical science research into the determinants and consequences of who was taught what, when, and how in public schools is rare. One challenge encountered by researchers is that structured and detailed (historical) comparative data about curricula is limited, also in Switzerland. We contribute to closing this gap by introducing HESSS, a novel dataset on the provision of home economics education (“Hauswirtschaftsunterricht”) in Switzerland in ten German‐speaking cantons for vocational‐ and university‐track secondary schools since 1980 and 1991, respectively. Our dataset can help scholars explore variation in home economics education over time and across cantons, and facilitate research on the Swiss educational system. In this research note, we outline the main features of the data and illustrate how they can be used in two applications: (i) tracking the switch from gender‐segregated to co‐educated home economics classes across cantons; and (ii) describing the impact of budget cuts on home economics in the canton of Zurich.
Metallogenic age of the world‐class giant huoshaoyun non‐sulphide Zn–Pb deposit in Karakoram Area, Xinjiang, Northwest China
Authors: Wang Da , Jia Wenbin , Li Yongsheng , Mathur Ryan , Yu Xiaofei , Lu Yvhan , Dai Meng , Yan Guangsheng 
Published: June 2024

AbstractMetallogenic geochronology plays a crucial role in the study of ore genesis and mineralization evolution. Unfortunately, accurately determining the metallogenic age of the non‐sulphide Zn–Pb deposits is difficult. Herein, we employed Rb–Sr dating of smithsonite and Sm–Nd dating of coexisting calcite to explore the mineralization ages of the Huoshaoyun Zn–Pb deposit. The Rb–Sr and Sm–Nd isotopic ratios yield isochron ages of 26.6 ± 1.7 and 27.5 ± 7.6 Ma, respectively. These obtained ages are identified as the metallogenic age of the Huoshaoyun deposit. Moreover, investigations into carbonate‐hosted Zn–Pb deposits in the East Tethys Metallogenic belt suggest they have formed in similar tectonic settings and yielded consistent Cenozoic ages. In sum, our research indicates that carbonate‐hosted Pb–Zn metallogenic ages in the East Tethys Metallogenic belt are principally concentrated in the late Palaeogene, and directly related to the collisional orogeny of the Tibetan Plateau during 40–26 Ma.
Coupling human mobility and social relationships to predict individual socioeconomic status: A graph neural network approach
Authors: Chen Xiao , Pei Tao , Song Ci , Shu Hua , Guo Sihui , Wang Xi , Liu Yaxi , Chen Jie 
Published: June 2024

AbstractUnderstanding individual's socioeconomic status (SES) can provide supporting information for designing political and economic policies. Acquiring large‐scale economic survey data is time‐consuming and laborious. The widespread mobile phone data, which can reflect human mobility and social network characteristics, has become a low‐cost data source for researchers to infer SES. However, previous studies often oversimplify human mobility features and social network features extracted from mobile phone data into general statistical features, resulting in discounting some important temporal and relational information. Therefore, we propose a comprehensive framework for individual SES prediction that effectively utilizes a combination of human mobility and social relationships. In this framework, Word2Vec module extracts human mobility features from mobile phone positioning data, and graph neural network (GNN) module GraphSAGE captures social network characteristics constructed from call detail records. We evaluated the effectiveness of our proposed approach by training the model with real‐world data in Beijing. According to the experimental results, our proposed hybrid approach outperformed the other methods evidently, demonstrating that human mobility and social links are complementary in the characterization of SES. Coupling human mobility and social links can further deepen our understanding of cities' economic geography.
Reexamining the Association Between Preseason Challenge and Threat States and Performance Across the Season
Authors: Jewiss Matthew , Hodgson Chris , Greenlees Iain 
Published: June 2024

Challenge and threat (C/T) states have been shown to predict sport performance under pressure. Nevertheless, only one study has examined whether preseason C/T states are associated with season-long performance, yielding promising findings. Despite promising findings, this work is not without limitations that warrant addressing. We aimed to address these limitations and contribute to the scarce literature which tests the effect of anticipatory C/T states on longer term performance. Thirty-eight amateur cricketers prepared and delivered two counterbalanced speeches: a control speech and a speech about an important cricket batting situation approximately 16 weeks prior to the start of their competitive season. Regression analysis showed that cardiovascular reactivity in anticipation of delivering a speech about an important cricket batting scenario the next season did not predict season-long batting performance. The findings have potential to challenge the role C/T states play in predicting longer term performance in the sport domain.