bluuebunny/crossref_metadata_2025_split huggingface dataset:
Has the revolution in scholarly communication lived up to its promise?
Authors: Hahn Trudi Bellardo , Burright Mariann , Duggan Heidi Nickisch 
Published: June 2011

AbstractEditor's SummaryIn the late 1990s the need for an overhaul in the approach to scholarly publishing was recognized. A drastic change would revise the economic model on which publishing was based, give authors rights to their own works in open access repositories and enable consumers across the world to access scholarly materials, building a flow of valuable information for the common good. The revolution has yet to materialize, though small but welcome achievements have been made. The open access business model has gained a foothold with the Public Library of Science (PLoS), and scientists receiving grants through the National Institutes of Health must submit manuscripts to the PubMed Central digital archive. Several universities mandate that faculty members deposit their scholarly articles in institutional repositories, and the Compact for Open Access Publishing Equity promotes open publishing by supporting authors. Librarians are both part of the problem and part of the solution. Instead of worrying about paying rising subscription fees, they could use their position to influence authors to take advantage of open access channels despite publish‐or‐perish pressures. Recent legislative and presidential initiatives, geared to disseminating publicly funded research, may be effective in moving open access closer to transforming the traditional system of scholarly communication.
Data, information, knowledge: The emerging field of health informatics
Authors: Dalrymple Prudence W. 
Published: June 2011

AbstractEditor's SummaryThe area of health informatics applies information science methods to analyze and understand health care information, to progress from raw data to knowledge, for improved problem solving, decision‐making and care delivery. With the field still relatively young and subspecialties already branching off, the terminology and scope continue to evolve. The fundamental model is shifting from treatment of an illness to wellness and disease prevention and viewing an individual's daily life in the broad context of factors that influence health. As the field takes shape, professional education is typically originating in health education for the informatician or in information science and technology for the health informaticist, with complementary coursework to expand understanding of and competency in the interdisciplinary field. The rapid growth and high demand for health informatics is stimulating an expansion of educational opportunities with degrees at all levels both in the United States and at international institutions. Conferences, professional publications and online resources on the topic multiply, serving those interested in making health informatics a career.
Information science as knowledge translation
Authors: Garnett Alex 
Published: June 2011

AbstractEditor's SummaryIn the medical field, knowledge translation is the process of putting research findings into action for patient education, practitioners' use and further research. It is a method of codifying what has been learned through research to improve communication within the professional community. The same view of knowledge sharing may be applied to library and information science (LIS). But the LIS community has been slow to adopt and implement our own research, to gain practical value by translating theory to knowledge. Greater attention should be paid to communication within the professional community to ensure the effective spread and use of knowledge gleaned from information science research. Just as medical informatics serves knowledge transfer in the field of medicine, exploring community informatics could shed light on how other disciplines, including LIS, translate knowledge to action through communication processes within professional communities.
Creating reusable and interoperable learning objects for developing an e‐learning system that supports remediation learning strategy
Authors: Lim Yeng Chai , Chiew Thiam Kian 
Published: June 2011

ABSTRACTe‐Learning is getting more important in education to provide new or enhanced services. Learning objects created according to e‐learning standards such as Sharable Content Object Reference Model (SCORM) play a major role in order to produce quality contents for e‐learning. A virtual learning environment (VLE) is normally used to support e‐learning by providing online courses and other learning activities. Moodle is one of the most widely used VLEs. However, Moodle still does not support the SCORM 2004 Sequencing and Navigation. This article proposes a new technique to create an e‐tutorial module, one of the main services in e‐learning that supports a certain level of SCORM 2004 Sequencing and Navigation on Moodle version 1.9.2+. This helps to provide learning with more control on the learning sequences and hence supports remediation learning strategy. Besides, study shows that courses built with learning objects complying with the SCORM 2004 standards are interoperable. © 2011 Wiley Periodicals, Inc. Comput Appl Eng Educ 22:329–339, 2014; View this article online at wileyonlinelibrary.com/journal/cae; DOI 10.1002/cae.20558
Instructing an on‐line VR‐based written test system design and construction in multimedia practice course
Authors: Liang Janus S. 
Published: June 2011

ABSTRACTInstructing multimedia practice is a fundamental issue in a computer science high‐level course. However, for an effective instruction of this subject an experience with real case study can be considered as fundamental. To achieve this goal, in this research a project for the practical learning of multimedia application and development is presented. This consists of an on‐line VR‐based written test system for automotive driving license. This research breaks down an on‐line VR‐based written test system into several portions that are suited for teamwork. Building this system it is possible to understand the performance and limitations of different tools, for example, multimedia, database, programming, etc., and to create a collaborative learning environment. We conclude with a rough timeline for modeling an on‐line written test system for automotive driving license during the course of a semester. © 2011 Wiley Periodicals, Inc. Comput Appl Eng Educ 22:349–363, 2014; View this article online at wileyonlinelibrary.com/journal/cae; DOI 10.1002/cae.20560
Pyrazolate‐Based Cobalt(II)‐Containing Metal–Organic Frameworks in Heterogeneous Catalytic Oxidation Reactions: Elucidating the Role of Entatic States for Biomimetic Oxidation Processes
Authors: Tonigold Markus , Lu Ying , Mavrandonakis Andreas , Puls Angela , Staudt Reiner , Möllmer Jens , Sauer Joachim , Volkmer Dirk 
Published: June 2011

AbstractCrystal structures of two metal–organic frameworks (MFU‐1 and MFU‐2) are presented, both of which contain redox‐active CoII centres coordinated by linear 1,4‐bis[(3,5‐dimethyl)pyrazol‐4‐yl] ligands. In contrast to many MOFs reported previously, these compounds show excellent stability against hydrolytic decomposition. Catalytic turnover is achieved in oxidation reactions by employing tert‐butyl hydroperoxide and the solid catalysts are easily recovered from the reaction mixture. Whereas heterogeneous catalysis is unambiguously demonstrated for MFU‐1, MFU‐2 shows catalytic activity due to slow metal leaching, emphasising the need for a deeper understanding of structure–reactivity relationships in the future design of redox‐active metal–organic frameworks. Mechanistic details for oxidation reactions employing tert‐butyl hydroperoxide are studied by UV/Vis and IR spectroscopy and XRPD measurements. The catalytic process accompanying changes of redox states and structural changes were investigated by means of cobalt K‐edge X‐ray absorption spectroscopy. To probe the putative binding modes of molecular oxygen, the isosteric heats of adsorption of O2 were determined and compared with models from DFT calculations. The stabilities of the frameworks in an oxygen atmosphere as a reactive gas were examined by temperature‐programmed oxidation (TPO). Solution impregnation of MFU‐1 with a co‐catalyst (N‐hydroxyphthalimide) led to NHPI@MFU‐1, which oxidised a range of organic substrates under ambient conditions by employing molecular oxygen from air. The catalytic reaction involved a biomimetic reaction cascade based on free radicals. The concept of an entatic state of the cobalt centres is proposed and its relevance for sustained catalytic activity is briefly discussed.
Site‐Specific Recognition of Guanosine by Manganese(III) Corroles in DNA Non‐Duplex Regions through Active Oxygen Transfer
Authors: Zhai Qianqian , Xu Liang , Ge Yushu , Tian Tian , Wu Wendi , Yan Shengyong , Zhou Yangyang , Deng Minggang , Liu Yi , Zhou Xiang 
Published: June 2011

AbstractDNA damage plays an important role in cellular processes. Besides natural protein nucleases, different types of efficient agents for DNA damage have been developed over recent decades in the search for new anticancer and antiviral drugs. In addition to the double‐stranded configuration, DNA structures also include some non‐duplex regions, which are considered to be from spontaneous errors in DNA replication, thus playing an important role for cells. Herein, we focused on these non‐duplex regions of DNA and generated manganese(III) corroles, which exhibit a highly selective cleavage ability for guanosine units located at non‐duplex portions, such as loops and bulges. The cleavage mechanism was demonstrated to be a manganese‐induced oxidation process. The results given herein show a molecular approach that could specifically probe the guanosine units in DNA non‐duplex structures, thus representing a promising step in the construction of tools to target non‐duplex structures in chromosomes.
Synthesis and C2‐symmetric structure of a cyclotetrapeptide composed of anthranilic acid and leucine
Authors: Akazome Motohiro , Enzu Masashi , Takagi Koji , Matsumoto Shoji 
Published: June 2011

AbstractA chiral cyclotetrapeptide (1) was synthesized from 2‐nitrobenzoic acid and leucine. A single‐crystal X‐ray of the compound revealed a C2‐symmetric bowl‐shaped structure. The cyclic compound had a unique hydrogen‐bonding network composed of three‐centered hydrogen bonds and bifurcated hydrogen bonds between NH and CO of anthranilic residue. The NMR spectra and molecular modeling of 1 also suggested the chiral bowl structure. Chirality, 2011. © 2011 Wiley‐Liss, Inc.
Rethinking Authority and Legitimacy in Strategy: A Perspective from an Emerging Economy
Authors: Faria Alex , Wensley Robin 
Published: June 2011

AbstractThe field of strategic management (SM) has presumed that the relationship between the state and market is unproblematic and that the role of the state should be seen solely within the context of regulation. Hence, the authority of CEOs within multinational corporations depends on the construction of its legitimate and sole validity and also on the delegitimation of other types of strategists—namely, government strategists. This paper emphasizes the territorial‐international dimension of authority and legitimacy to argue that the SM literature delegitimates the authority of government strategists. The paper suggests that SM in Brazil can be reorientated to help restore the legitimate authority of government strategists and challenge the sole privileging of strategists within big corporations. Copyright © 2011 ASAC. Published by John Wiley & Sons, Ltd.
Miniemulsions using static mixers: Part 2. Co‐emulsification and composite materials using SMX static mixers
Authors: Farzi G. A. , Bourgeat‐Lami E. , McKenna T. F. L. 
Published: June 2011

AbstractA 50:50 mixture of methylmethacrylate (MMA) and butyl acrylate was emulsified, then polymerised using different static mixers. It was shown that the emulsification behaviour was very different from that observed for MMA alone under similar conditions. It was shown that the hydrophobicity of the monomers had a strong influence on the droplet size and stability. It was also shown that the amount of work done on the emulsion is important for obtaining polymerisable droplets, and that monomer systems that are difficult to miniemulsify with a low energy system can in fact be made to form stable emulsions simply by changing the emulsification conditions. Finally, it was shown that when the miniemulsification conditions are correctly chosen, it is possible to generate miniemulsion dispersions containing silica that can be successfully polymerised to produce silica/polyacrylic nanocomposites.
Power and flow characteristics of three rotor‐stator heads
Authors: Özcan‐Taşkın Gül , Kubicki Dominik , Padron Gustavo 
Published: June 2011

AbstractIn‐line rotor‐stators are used in a wide range of industrial applications—primarily for dispersion processes such as emulsification, deagglomeration. Three rotor‐stator heads have been used to investigate their performance in breaking up of nanoparticle clusters within a large project. This article reports the findings of a part of this study aimed at investigating the flow and power characteristics in single phase to highlight the differences of three different mixer heads. Power characteristics are determined using the calorimetry allowing the characteristic power numbers for these devices to be obtained. These are also compared with CFD calculations. Flow characteristics are studied through numerical simulations.
Removal of ammonium cations from aqueous solution using arene‐sulphonic acid functionalised SBA‐15 as adsorbent
Authors: Rat‐Valdambrini Micha , Belkacemi Khaled , Hamoudi Safia 
Published: June 2011

AbstractRemoval of ammonium cations from aqueous solution was investigated using an arene‐sulphonic acid functionalised mesostructured SBA‐15 material as adsorbent. Arene‐sulphonic acid‐SBA‐15 (AS‐SBA‐15) was prepared via a co‐condensation strategy using tetraethylorthosilicate (TEOS) and 2‐(4‐chlorosulphonylphenyl)ethyltrimethoxysilane (CSPTMS) as framework precursors under acidic conditions. The material exhibited high surface area (680 m2/g) and total pore volume (0.84 mL/g). The effects of adsorbent loading, initial ammonium concentration, temperature, pH and the presence of competitive ions on the adsorption performances were investigated. The ammonium removal increased with the increase of the adsorbent loading and the decrease of the initial concentration. The adsorption capacity decreased with increasing the temperature. Maximum adsorption capacity obtained at 5°C was ca. 19 mg NH/g adsorbent. The isotherms data were studied using different adsorption models and thermodynamic parameters were calculated. Competitive ions such K+ and Na+ slightly affected the ammonium adsorption. After six adsorption–desorption cycles, the adsorbent retained its adsorption capacity.
Vapour–liquid equilibrium of CO2 in aqueous solutions of N‐methyl‐2‐ethanolamine
Authors: Kumar G. , Kundu M. 
Published: June 2011

AbstractThe equilibrium solubility of CO2 into aqueous solution of sterically hindered N‐methyl‐2‐ethanolamine or methyl amino ethanol (MAE) was investigated in the temperature range of 303.1–323.1 K and total CO2 pressure in the range of 1–350 kPa. The N‐methyl‐2‐ethanolamine aqueous solutions studied were 0.968, 1.574, 2.240 and 3.125 mol kg−1 of solvent. © 2011 Canadian Society for Chemical Engineering
Heart Failure After Myocardial Infarction: Clinical Implications and Treatment
Authors: Minicucci Marcos F. , Azevedo Paula S. , Polegato Bertha F. , Paiva Sergio A.R. , Zornoff Leonardo A. M. 
Published: June 2011

AbstractHeart failure is a frequent complication of myocardial infarction. Several factors, such as recurrent myocardial ischemia, infarct size, ventricular remodeling, stunned myocardium, mechanical complications, and hibernating myocardium influence the appearance of left ventricular systolic dysfunction after myocardial infarction. Importantly, its presence increases the risk of death by at least 3‐ to 4‐fold. The knowledge of the mechanisms and clinical features are essential for the diagnosis and treatment of left ventricular dysfunction and heart failure after myocardial infarction. Therefore, this review will focus on the clinical implications and treatment of heart failure after myocardial infarction. © 2011 Wiley Periodicals, Inc.The authors have no funding, financial relationships, or conflicts of interest to disclose.
An Amphiphilic Conjugate Approach toward the Design and Synthesis of Betulinic Acid–Polyphenol Conjugates as Inhibitors of the HIV‐1 gp41 Fusion Core Formation
Authors: Liu Yan , Ke Zhuofeng , Wu Kwok Yiu , Liu Shuwen , Chen Wen‐Hua , Jiang Shibo , Jiang Zhi‐Hong 
Published: June 2011

AbstractExploration of potent inhibitors of the HIV‐1 gp41 fusion core formation is a promising strategy to discover small‐molecule HIV‐1 entry inhibitors for the treatment of HIV‐1 infection. In this paper, a series of novel betulinic acid–polyphenol conjugates was designed, guided by molecular modeling of the binding of betulinic acid (BA) and phenolic galloyl/caffeoyl groups in the groove on the gp41 N‐terminal heptad repeat (NHR) trimeric coiled coil. These conjugates were synthesized via conjugation of galloyl and caffeoyl groups with BA at the C‐28 position. Their inhibitory activities of HIV gp41 six‐helix bundle (6‐HB) formation between the NHR peptide N36 and the C‐terminal heptad repeat (CHR) peptide C34 were evaluated with size‐exclusion HPLC. Conjugates bearing a galloyl group were found to exhibit four to sixfold higher inhibitory activities than that of parent compound BA, suggesting that they may be exploitable as HIV‐1 fusion/entry inhibitors targeting gp41. The docking study on BA and its derivatives suggests that hydrophobic and hydrogen‐bonding pockets exist in the groove of the gp41 NHR trimeric coiled coil and that a potent inhibitor should have amphiphilic structures to cooperatively interact with both pockets. This possibility was explored by incorporating both lipophilic and hydrophilic groups into the conjugates in a well‐defined orientation to bind with both pockets in the gp41 NHR‐trimer.
Neurodevelopmental MRI brain templates for children from 2 weeks to 4 years of age
Authors: Sanchez Carmen E. , Richards John E. , Almli C. Robert 
Published: June 2011

AbstractSpatial normalization and segmentation of pediatric brain magnetic resonance images (MRI) data with adult templates may impose biases and limitations in pediatric neuroimaging work. To remedy this issue, we created a single database made up of a series of pediatric, age‐specific MRI average brain templates. These average, age‐specific templates were constructed from brain scans of individual children obtained from two sources: (1) the NIH MRI Study of Normal Brain Development and (2) MRIs from University of South Carolina's McCausland Brain Imaging Center. Participants included young children enrolled at ages ranging from 8 days through 4.3 years of age. A total of 13 age group cohorts spanning the developmental progression from birth through 4.3 years of age were used to construct age‐specific MRI brain templates (2 weeks, 3, 4.5, 6, 7.5, 9, 12, 15, 18 months, 2, 2.5, 3, 4 years). Widely used processing programs (FSL, SPM, and ANTS) extracted the brain and constructed average templates separately for 1.5T and 3T MRI volumes. The resulting age‐specific, average templates showed clear changes in head and brain size across ages and between males and females, as well as changes in regional brain structural characteristics (e.g., myelin development). This average brain template database is available via our website (http://jerlab.psych.sc.edu/neurodevelopmentalmridatabase) for use by other researchers. Use of these age‐specific, average pediatric brain templates by the research community will enhance our ability to gain a clearer understanding of the early postnatal development of the human brain in health and in disease. © 2011 Wiley Periodicals, Inc. Dev Psychobiol 54:77–91, 2012.
Presynaptic modulation of early olfactory processing in Drosophila
Authors: Wang Jing W. 
Published: June 2011

AbstractMost animals are endowed with an olfactory system that is essential for finding foods, avoiding predators, and locating mating partners. The olfactory system must encode the identity and intensity of behaviorally relevant stimuli in a dynamic environmental landscape. How is olfactory information represented? How is a large dynamic range of odor concentrations represented in the olfactory system? How is this representation modulated to meet the demands of different internal physiological states? Recent studies have found that sensory terminals are important targets for neuromodulation. The emerging evidence suggests that presynaptic inhibition scales with sensory input and thus provides a mechanism to increase dynamic range of odor representation. In addition, presynaptic facilitation could be a mechanism to alter behavioral responses in hungry animals. This review will focus on the GABAB (gamma‐aminobutyric acid) receptor‐mediated presynaptic inhibition, and neuropeptide‐mediated presynaptic modulation in Drosophila © 2011 Wiley Periodicals, Inc. Develop Neurobiol 72:87–99, 2012
Aberrant expression of genes necessary for neuronal development and notch signaling in an epilepticmind bombzebrafish
Authors: Hortopan Gabriela A. , Baraban Scott C. 
Published: June 2011

AbstractMutation within an ubiquitin E3 ligase gene can lead to a failure in Notch signaling, excessive neurons, and depletion of neural progenitor cells inmind bombmutants. Usingmibhi904zebrafish, we reported seizures and a down‐regulation of γ‐aminobutyric acid (GABA) signaling pathway genes. A transcriptome analysis also identified differential expression pattern of genes related to Notch signaling and neurodevelopment. Here, we selected nine of these genes (her4.2,hes5,bhlhb5,hoxa5a,hoxb5b,dmbx1a,dbx1a,nxph1, andplxnd1) and performed a more thorough analysis of expression using conventional polymerase chain reaction, real‐time polymerase chain reaction and in situ hybridization. Transgenic reporter fish (Gfap:GFP and Dlx5a‐6a:GFP) were used to assess early brain morphology in vivo. Down‐regulation of many of these genes was prominent throughout key structures of the developingmibhi904zebrafish brain including, but not limited to, the pallium, ventral thalamus, and optic tectum. Brain expression of Dlx5a‐6a and Gfap was also reduced. In conclusion, these expression studies indicate a general down‐regulation of Notch signaling genes necessary for proper brain development and suggest that these mutant fish could provide valuable insights into neurological conditions, such as Angelman syndrome, associated with ubiquitin E3 ligase mutation. Developmental Dynamics 240:1964–1976, 2011. © 2011 Wiley‐Liss, Inc.