bluuebunny/crossref_metadata_2025_split huggingface dataset:
Gemcitabine‐associated livedoid thrombotic microangiopathy with associated sclerema neonatorum‐like microscopic changes
Authors: Mir‐Bonafé José M. , Román‐Curto Concepción , Santos‐Briz Ángel , Cañueto Javier , Fernández‐López Emilia , Unamuno Pablo 
Published: May 2012

Gemcitabine is a deoxycytidine analog antimetabolite that is now accepted as first‐line treatment for advanced and metastatic pancreatic carcinoma. Gemcitabine‐related thrombotic microangiopathy associated with systemic hemolytic‐uremic syndrome or thrombotic thrombocytopenia purpura has rarely been described. Herein, we report a patient who developed a livedoid thrombotic microangiopathy with no signs of associated hemolytic‐uremic syndrome. Cutaneous thrombotic microangiopathy occurred after the administration of his 17th cycle and a cumulative dose of 53.65 g/m2 of gemcitabine. Some authors have suggested that this toxicity may be dose‐related, and a 10th cycle or a cumulative dose of 9–56 g/m2 have been proposed as the prothrombotic threshold. Interestingly, dermatopathologic findings were limited to the subcutis and they consisted of small‐vessel occlusion by intravascular fibrin and leukocytes, vessel wall thickening and endothelial cell swelling. Surprisingly, we observed some structures arranged radially with needle‐shaped clefts resembling those of sclerema neonatorum. Awareness of this potential cutaneous toxicity by dermatologists and dermatopathologists is extremely important.Mir‐Bonafé JM, Román‐Curto C, Santos‐Briz A, Cañueto J, Fernández‐López E, Unamuno P. Gemcitabine‐associated livedoid thrombotic microangiopathy with associated sclerema neonatorum‐like microscopic changes.
Manual microdissection technique in a case of subcutaneous panniculitis‐like T‐cell lymphoma: a case report and review
Authors: Hoffman Daniel , Chaffins Marsha , Cankovic Milena , Maeda Koichi , Meehan Shane 
Published: May 2012

Demonstration of T‐cell receptor gene monoclonality often plays an important role in the diagnosis of T‐cell lymphoma. When a test to detect monoclonality is performed on whole tissue sections, the presence of a reactive lymphocyte population may reduce sensitivity. This may be especially true for early or borderline cases of lymphoma. Microdissection techniques may be utilized to more readily identify a clonal population of lymphocytes. Subcutaneous panniculitis‐like T‐cell lymphoma represents a cutaneous lymphoid neoplasm whose clinical course may vary from an indolent, waxing and waning course to an aggressive course resulting in death. We report the first case of a microdissection technique used to facilitate diagnosing a case of subcutaneous panniculitis‐like T‐cell lympoma.Hoffman D, Chaffins M, Cankovic M, Maeda K, Meehan S. Manual microdissection technique in a case of subcutaneous panniculitis‐like T‐cell lymphoma: a case report and review.
Performance of an artificial neural network for vertical root fracture detection: an ex vivo study
Authors: Kositbowornchai Suwadee , Plermkamon Supattra , Tangkosol Tawan 
Published: May 2012

AbstractAimTo develop an artificial neural network for vertical root fracture detection.Materials and methodsA probabilistic neural network design was used to clarify whether a tooth root was sound or had a vertical root fracture. Two hundred images (50 sound and 150 vertical root fractures) derived from digital radiography – used to train and test the artificial neural network – were divided into three groups according to the number of training and test data sets: 80/120,105/95 and 130/70, respectively. Either training or tested data were evaluated using grey‐scale data per line passing through the root. These data were normalized to reduce the grey‐scale variance and fed as input data of the neural network. The variance of function in recognition data was calculated between 0 and 1 to select the best performance of neural network. The performance of the neural network was evaluated using a diagnostic test.ResultsAfter testing data under several variances of function, we found the highest sensitivity (98%), specificity (90.5%) and accuracy (95.7%) occurred in Group three, for which the variance of function in recognition data was between 0.025 and 0.005.ConclusionsThe neural network designed in this study has sufficient sensitivity, specificity and accuracy to be a model for vertical root fracture detection.
Traumatic dental injuries at a German University Clinic 2004–2008
Authors: Bücher Katharina , Neumann Claudia , Hickel Reinhard , Kühnisch Jan 
Published: May 2012

AbstractAimThis study was designed to analyse the distribution and treatment management of patients who presented at a German university dental emergency department for trauma in a 5‐year period.Materials/MethodsClinical and radiographical baseline data and recall of patients presenting from 2004 to 2008 for dental trauma were evaluated with regard to age, gender, type of injury and treatment strategies. In addition, trauma management as performed was compared with the guidelines of the International Association of Dental Traumatology (IADT).ResultsA total of 361 teeth in 219 patients from 1 to 68 years were treated with 1.7 injured teeth per incident and patient. Over 75% of the patients were < 14 years. In 23% of all incidents, primary teeth were affected with a male‐to‐female ratio of 2.1:1. Luxation injuries were predominant in the deciduous dentition. The domestic environment was the most common trauma location (44%), followed by nursery schools (36%) and outdoors during recreational activities (20%) mainly caused by falls (72%). In 76% of all dental injuries, permanent teeth were involved; 65% of patients were men; and 35%, women (1.8:1). With permanent teeth, enamel‐dentine fracture without pulp involvement was most common. Falls (38%), accidental contacts (21%) and sports accidents (18%) caused the most injuries. The majority of teeth were treated in concordance with the guidelines (89%).ConclusionsThe distribution of traumatic injuries is similar to other national and international data with regard to gender, age and in relation to injury type, location and causes. International and national healthcare associations and teachers in under‐ and postgraduate education should put effort on increasing the awareness of the guidelines.
Efficacy and tolerability of blonanserin in 48 patients with intractable schizophrenia
Authors: Takaki Manabu , Okahisa Yuko , Kodama Masafumi , Mizuki Yutaka , Sakamoto Shinji , Ujike Hiroshi , Uchitomi Yosuke 
Published: May 2012

Takaki M, Okahisa Y, Kodama M, Mizuki Y, Sakamoto S, Ujike H, Uchitomi Y. Efficacy and tolerability of blonanserin in 48 patients with intractable schizophrenia.Background: Blonanserin is effective for the treatment of schizophrenia in Korea and Japan.Methods: We administered blonanserin to 48 Japanese patients with schizophrenia for whom other atypical antipsychotics were not sufficiently effective or tolerated.Results: Previous antipsychotics were replaced with blonanserin because of its effectiveness (54.2%; 26/48) or tolerability (45.8%; 22/48). Blonanserin was more effective in 65.4% (17/26) of the and better tolerated in 95.5% (21/22) of the patients. Of 48 patients, 33 continued blonanserin for 1 year. The mean Clinical Global Impression of Severity scores improved from 4.60 to 2.48. The mean Global Assessment of Functioning score improved from 29.8 to 51.7. Nineteen patients (39.6%; 19/48) had a social role. The reasons for discontinuation of blonanserin were ineffectiveness against psychosis (27.1%; 13/48) or intolerability (4.2%; 2/48). The ratio of discontinuation for intolerability versus ineffectiveness was 0.15, which was the lowest among atypical psychotics.Conclusions: Blonanserin may be effective and safe for the treatment of intractable schizophrenia.
Asymptomatic nodules of the upper lip: report of a canalicular adenoma with immunoprofile presentation
Authors: Oliveira‐Santos Christiano , Freitas‐Faria Patrícia , Damante José Humberto , Consolaro Alberto 
Published: May 2012

doi: 10.1111/j.1741‐2358.2010.00388.xAsymptomatic nodules of the upper lip: report of a canalicular adenoma with immunoprofile presentationCanalicular adenoma is an uncommon benign tumour that generally arises in the minor salivary glands of individuals over 60 years old. This study illustrates a case of canalicular adenoma in a 70‐year‐old female, presenting as two distinct asymptomatic nodules in the upper lip. Immunohistochemistry analysis was performed. Clinical features, management, histology and immunoprofile from this case and from the literature are discussed.
Prevention of trauma to edentulous ridge from opposing natural teeth
Authors: Singh Kunwarjeet , Aeran Himanshu , Gupta Nidhi 
Published: May 2012

doi: 10.1111/j.1741‐2358.2010.00397.xPrevention of trauma to edentulous ridge from opposing natural teethObjective:  To suggest a technique to prevent trauma of the edentulous ridge from opposing natural or restored teeth.Background:  The prevalence of the condition where one edentulous arch opposes a natural or restored dentition is quite common. In most of cases, the maxillary arch is completely edentulous and either all teeth or only anterior teeth are present in the mandibular arch. These remaining teeth may continuously cause trauma to the opposing edentulous ridge during the night when a removable prosthesis is kept out of the mouth.Materials and methods:  A thermoplastic acrylic resin mouthguard was fabricated on a cast of the remaining teeth dentition.Conclusion:  This article presents a simple and inexpensive procedure to prevent self‐induced trauma of the edentulous ridge from opposing natural teeth by using a thermoplastic acrylic resin mouthguard.
Oral desmoplastic melanoma mimicking inflammatory hyperplasia
Authors: Jou Adriana , Miranda Fábio V. , Oliveira Márcia G. , Martins Manoela D. , Rados Pantelis V. , Filho Manoel S. 
Published: May 2012

doi: 10.1111/j.1741‐2358.2011.00482.xOral desmoplastic melanoma mimicking inflammatory hyperplasiaIntroduction:  Desmoplastic melanoma (DM) arising in the oral cavity is a rare neoplasm that may be confused with a variety of non‐melanocytic benign or malignant lesions.Objectives:  To present a case of DM in the oral mucosa mimicking fibrous inflammatory hyperplasia, discusses the difficulties involved in the diagnosis and offers a literature review on the clinicopathologic and immunohistochemincal aspects of this neoplasm.Case report:  A 62‐year‐old white male, smoker, was referred with a chief complaint of pain and swelling in the palate. The oral examination revealed multiple brown‐to‐black patches and a non‐pigmented sessile nodule located on the mucosa of the hard palate. The clinical diagnosis of the pigmented lesions was either oral melanosis or melanoma. The nodular lesion was clinically diagnosed as fibrous inflammatory hyperplasia. Incisional biopsy was performed on the pigmented lesion and the microscopic sections revealed a melanotic macule. The nodular lesions histologically revealed an amelanotic desmoplastic melanoma.Conclusions:  Reactive lesions close to a pigmented area should be investigated with great care.
Antifungal and physical characteristics of modified denture base acrylic incorporated with silver nanoparticles
Authors: Nam Ki‐Young , Lee Cheong‐Hee , Lee Chul‐Jae 
Published: May 2012

doi: 10.1111/j.1741‐2358.2011.00489.xAntifungal and physical characteristics of modified denture base acrylic incorporated with silver nanoparticlesObjective:  This study evaluated the antifungal and physical characteristics of denture base acrylic combined with silver nanoparticles.Materials and methods:  Polymerized denture acrylic disc specimens containing 0 (control), 1.0, 5.0, 10.0, 20.0 and 30.0 wt% of silver nanoparticles were placed on separate culture plate dish and 100 ìL samples of yeast suspension of Candida albicans strain were inoculated on each specimens and incubated at 37°C, for 24 h. The antifungal effects were evaluated as a number of viable cells in retrieved fungal suspension. To characterize physical aspects, specimens were tested for elution of silver cation (Ag+) at 24 h and 30th day, thermal analysis (TG/DTA), scanning electron microscope and energy dispersed X‐ray analysis (SEM/EDX) and color stability.Results:  Significant reduced CFU was exhibited at 20.0 and 30.0 wt% of silver nanoparticles incorporated (p < 0.01) and Ag+ elution from specimens (maximum 0.356 ± 0.11 mg/L) contributed little to the antifungal activity considering MIC of Ag+ in this study (3.0 mg/L). The successful synthesis of modified denture acrylic containing silver nanoparticles was accessed by TG/DTA and EDX analysis.Conclusion:  The modified denture base acrylic combined with silver nanoparticles displayed antifungal properties and acted like latent antifungal material itself with low‐releasing Ag+, however, the improvement of poor color stability was still required.
Leishmaniasis with oral mucosa involvement
Authors: Pellicioli Ana C. A. , Martins Marco A. T. , Filho Manoel Sant’ana , Rados Pantelis V. , Martins Manoela D. 
Published: May 2012

doi: 10.1111/j.1741‐2358.2011.00512.xLeishmaniasis with oral mucosa involvementIntroduction:  The term leishmaniasis comprises a group of diseases caused by different protozoan species of the genus Leishmania. There are three main clinical forms of leishmaniasis: visceral, cutaneous and mucocutaneous. Exclusive involvement of the mucosa is very rare.Objectives:  To present a case of mucocutaneous leishmaniasis in an elderly patient, discuss the clinical presentation, diagnostic process and treatment emphasizing the distinctions from other granulomatous lesions.Case report:  A 71‐year‐old male presenting with a symptomatic lesion on the hard and soft palate, which had developed over a period of 6 months was evaluated. The oral exam revealed a lesion with multiple ulcerated nodules on the hard and soft palate extending to the oropharynx. The diagnostic hypothesis was chronic infectious disease (paracoccidioidomycose, tuberculosis and leishmaniasis) or squamous cell carcinoma. Histopathological, histochemical and immunohistochemical analysis were performed. A chest x‐ray revealed a normal pulmonary pattern. The Montenegro skin test was positive. The definitive diagnosis was leishmaniasis with exclusive oral manifestation and the patient was treated with liposomal amphotericin.Conclusions:  Localized oral mucosa leishmaniasis is an uncommon event in an immunocompetent patient. Dentists play an important role in the diagnosis of oral leishmaniasis, which has systemic repercussions.
CAD/CAM treatment for the elderly – a case report
Authors: Van Zeghbroeck Lieve 
Published: May 2012

doi: 10.1111/j.1741‐2358.2011.00521.xCAD/CAM treatment for the elderly – a case reportBackground:  When elderly develop signs and symptoms of Alzheimer’s disease they lose their independence and neglect dental hygiene. Dentists are increasingly confronted by seniors who are in need but who have limited access to dental care. Caretakers and family are also often confronted with behaviour problems besides the dental problems.Objective:  To report the importance of shorter and lower impact treatment for seniors when caretakers and family are confronted with a behavioural problem in addition to the dental problem.Materials and methods:  In this case report, the oral management of a patient with Alzheimer’s disease was described using chairside computer‐aided design/computer‐aided manufacturing (CAD/CAM) technology while constructing a bonded bridge.Discussion:  The case report emphasises the importance of interaction with the patient and added a treatment method for patients with limited cognitive skills who become easily agitated or aggressive.Conclusion:  The fabrication of a full ceramic bonded bridge utilising the Cerec 3D chairside CAD/CAM technology in an Alzheimer patient has been shown to be a feasible, precise, aesthetic and durable solution. It added a technique for intervening with patients with limited tolerance for dental procedures, which improves the quality of life of both patient and family.
Social interactions, body image and oral health among institutionalised frail elders: an unexplored relationship
Authors: Donnelly Leeann R. , MacEntee Michael I. 
Published: May 2012

doi: 10.1111/j.1741‐2358.2011.00523.xSocial interactions, body image and oral health among institutionalised frail elders: an unexplored relationshipObjectives:  This paper draws on theories of ageing, body image and disfigurement, to explore the potential for relationships between oral health, body image and social interactions between institutionalised elders.Background:  Social relationships are important at all stages of life. A positive body image increases confidence in social interactions, which contributes substantially to health, well‐being and quality of life. Body image can be negatively impacted by oral conditions, particularly those that are appearance related and do not meet cultural ideals.Results:  Typically, the oral health of frail elders in long‐term care facilities is poor, but to what extent poor oral health and dysfunction influence body image, and social behaviours is unclear.Conclusions:  We conclude that there is the potential for poor oral health conditions to contribute negatively to the social well‐being in this population, but suggest that it requires further investigation.
Implant‐supported palatal lift prosthesis in a patient with velopharyngeal incompetence: a case report
Authors: Montagner Aline , da Fontoura Frasca Luis Carlos , Rivaldo Elken Gomes 
Published: May 2012

doi: 10.1111/j.1741‐2358.2011.00561.xImplant‐supported palatal lift prosthesis in a patient with velopharyngeal incompetence: a case reportObjective:  To describe the use of dental implants in the treatment of velopharyngeal incompetence.Background:  Velopharyngeal incompetence is characterized by the inability to contract the tissues of the soft palate. The most common causes are neuromuscular problems resulting from concussion and degenerative conditions of the central nervous system.Materials and methods:  The treatment using palatal lift prosthesis is well established in the literature; however, reports on the use of osseointegrated implants are scarce. Rehabilitation using only this type of fibromucosal support is difficult in edentulous patients, since the prosthesis has a palatal lift extension.Results:  The implants provided retention and stability to the prosthesis, improving swallowing and speech and contributing to improve the patient’s quality of life.Conclusion:  This article reports the rehabilitation of a patient with a totally edentulous maxilla with velopharyngeal incompetence using an implant‐retained palatal lift prosthesis.
Surgical and prosthetic treatment in an elderly patient affected by unilateral idiopathic gingival fibromatosis: a case report
Authors: Millet Catherine , Rodier Philippe , Farges Jean‐Christophe , Labert Nicolas , Duprez Jean‐Pierre 
Published: May 2012

doi: 10.1111/j.1741‐2358.2011.00564.xSurgical and prosthetic treatment in an elderly patient affected by unilateral idiopathic gingival fibromatosis: a case reportObjectives:  The aim was to present the diagnosis and treatment of a case of unilateral idiopathic gingival fibromatosis (IGF) in a geriatric patient.Background:  IGF is a rare condition characterised by an enlargement of the attached and marginal gingivae with no obvious association to any causative factor. Gingival overgrowth causes inaesthetic changes and clinical symptoms such as speech disturbances, tooth movement, and occlusal problems.Materials and methods:  A 65‐year‐old female presented localised enlargement of mandibular gingiva, malpositioning of anterior mandibular teeth, and difficulty in speech and mastication. IGF also causes numerous aesthetic and psychological problems. Treatment consisted of multiple extractions, surgical therapy, and early prosthetic rehabilitation to restore function and appearance and to prevent recurrence.Results:  Excellent aesthetic result and psychological benefit were achieved, and no fibromatosis recurrence was detected after 1 year following surgery.Conclusion:  Gingival resection of the tissue excess and early oral rehabilitation with removable dentures have so far greatly improved patient’s quality of life.
Management of a dentigerous cyst in a medically compromised geriatric patient: a case report
Authors: Loomba Anju , Loomba Kapil , Bains Rhythm , Bains Vivek K. 
Published: May 2012

doi: 10.1111/j.1741‐2358.2011.00576.xManagement of a dentigerous cyst in a medically compromised geriatric patient: a case reportBackground:  Because of the increasing number of older persons seeking dental care, the growing trend towards a longer dental appointment and increased administration of drugs in dentistry, the possibility of occurrence of medical emergencies in dental offices has shown an upward trend.Objective:  This case report discusses enucleation of a central dentigerous cyst in a 72‐year old male on long‐term low dose aspirin therapy.Material and methods:  Surgical removal of impacted tooth with total enucleation of cystic lesion was performed in the dental chair under 2% lidocaine with 1:200,000 adrenaline, 3 days after aspirin cessation. After complete debridement of the surgical site, the wound was sutured and a gauge saturated with 10% tranexamic acid was placed on surgical site for 30 minutes.Result:  No post‐operative complications or bleeding was seen on subsequent appointment and healing was normal.Conclusion:  A geriatric and medically compromised patient demands special care and attention; and the decision to cease aspirin before surgery or not is of critical importance.
Pulp sensibility test in elderly patients
Authors: Farac Roberta Vieira , Morgental Renata Dornelles , de Pontes Lima Regina Karla , Tiberio Denise , dos Santos Maria Teresa Botti Rodrigues 
Published: May 2012

doi: 10.1111/j.1741‐2358.2012.00623.x

Pulp sensibility test in elderly patientsBackground:  The ageing process transforms the histological composition of the dental pulp and may affect the response to pulp sensibility tests.Objectives:  The aim of this study was to assess the influence of age on pulp response time and on pain intensity.Material and methods:  Fifty elderly patients and 50 young patients were selected. Different classes of teeth were evaluated. The pulp sensibility test was performed with a refrigerant spray. The pulp response time was measured in seconds and the pain intensity was assessed by visual analogue scale.Results:  The Spearman coefficient was calculated and detect a positive correlation between age and pulp response time for maxillary incisors, premolars, mandibular incisors, and mean (p < 0.05). On the contrary, there was a negative correlation between age and pain intensity for maxillary incisors, mandibular incisors, and mean (p < 0.05). Also, the results of elderly and young groups were compared by Mann–Whitney test. Significant difference was noted regarding the pulp response time for maxillary incisors, premolars, mandibular incisors, and mean (p < 0.05). Significant difference was detected regarding the pain intensity for mandibular incisors only (p < 0.05).Conclusions:  Pulp response time increases when people get older while pain intensity decreases. There were variations among the classes of teeth.