bluuebunny/crossref_metadata_2025_split huggingface dataset:
Development of a chest X-ray machine learning convolutional neural network model on a budget and using artificial intelligence explainability techniques to analyze patterns of machine learning inference
Authors: Lee Stephen B 
Published: May 2024

Abstract

Objective
Machine learning (ML) will have a large impact on medicine and accessibility is important. This study’s model was used to explore various concepts including how varying features of a model impacted behavior.

Materials and Methods
This study built an ML model that classified chest X-rays as normal or abnormal by using ResNet50 as a base with transfer learning. A contrast enhancement mechanism was implemented to improve performance. After training with a dataset of publicly available chest radiographs, performance metrics were determined with a test set. The ResNet50 base was substituted with deeper architectures (ResNet101/152) and visualization methods used to help determine patterns of inference.

Results
Performance metrics were an accuracy of 79%, recall 69%, precision 96%, and area under the curve of 0.9023. Accuracy improved to 82% and recall to 74% with contrast enhancement. When visualization methods were applied and the ratio of pixels used for inference measured, deeper architectures resulted in the model using larger portions of the image for inference as compared to ResNet50.

Discussion
The model performed on par with many existing models despite consumer-grade hardware and smaller datasets. Individual models vary thus a single model’s explainability may not be generalizable. Therefore, this study varied architecture and studied patterns of inference. With deeper ResNet architectures, the machine used larger portions of the image to make decisions.

Conclusion
An example using a custom model showed that AI (Artificial Intelligence) can be accessible on consumer-grade hardware, and it also demonstrated an example of studying themes of ML explainability by varying ResNet architectures.
Automatic detection of faults in industrial production of sandwich panels using Deep Learning techniques
Authors: Lopez Florez Sebastian , González-Briones Alfonso , Chamoso Pablo , Saberi Mohamad Mohd 
Published: May 2024

Abstract
The use of technologies like artificial intelligence can drive productivity growth, efficiency and innovation. The goal of this study is to develop an anomaly detection method for locating flaws on the surface of sandwich panels using YOLOv5. The proposed algorithm extracts information locally from an image through a prediction system that creates bounding boxes and determines whether the sandwich panel surface contains flaws. It attempts to reject or accept a product based on quality levels specified in the standard. To evaluate the proposed method, a comparison was made with a sandwich panel damage detection method based on a convolutional neural network and methods based on thresholding. The findings show that the proposed method, which is based on an object detector, is more accurate than the alternatives. The characteristics of the model, which can reject or accept a product according to the standard and limit allowable manufacturing flaws to obtain a quality product, also enable this system to improve industrial standards for producing sandwich panels while increasing speed.
Nonparametric measure-transportation-based methods for directional data
Authors: Hallin M , Liu H , Verdebout T 
Published: May 2024

Abstract
This article proposes various nonparametric tools based on measure transportation for directional data. We use optimal transports to define new notions of distribution and quantile functions on the hypersphere, with meaningful quantile contours and regions and closed-form formulas under the classical assumption of rotational symmetry. The empirical versions of our distribution functions enjoy the expected Glivenko–Cantelli property of traditional distribution functions. They provide fully distribution-free concepts of ranks and signs and define data-driven systems of (curvilinear) parallels and (hyper)meridians. Based on this, we also construct a universally consistent test of uniformity and a class of fully distribution-free and universally consistent tests for directional MANOVA which, in simulations, outperform all their existing competitors. A real-data example involving the analysis of sunspots concludes the article.
Redox signaling and oxidative stress in systemic acquired resistance
Authors: Liu Cheng , Liu Qingcai , Mou Zhonglin 
Published: May 2024

Abstract
Plants fully depend on their immune systems to defend against pathogens. Upon pathogen attack, plants not only activate immune responses at the infection site but also trigger a defense mechanism known as systemic acquired resistance (SAR) in distal systemic tissues to prevent subsequent infections by a broad-spectrum of pathogens. SAR is induced by mobile signals produced at the infection site. Accumulating evidence suggests that reactive oxygen species (ROS) play a central role in SAR signaling. ROS burst at the infection site is one of the earliest cellular responses following pathogen infection and can spread to systemic tissues through membrane-associated NADPH oxidase-dependent relay production of ROS. It is well known that ROS ignite redox signaling and, when in excess, cause oxidative stress, damaging cellular components. In this review, we summarize current knowledge on redox regulation of several SAR signaling components. We discuss the ROS amplification loop in systemic tissues involving multiple SAR mobile signals. Moreover, we highlight the essential role of oxidative stress in generating SAR signals including azelaic acid and extracellular NAD(P) [eNAD(P)]. Finally, we propose that eNAD(P) is a damage-associated molecular pattern serving as a converging point of SAR mobile signals in systemic tissues.
Constraints on the narrow-line region of the X-ray quasi-periodic eruption source GSN 069
Authors: Patra Kishore C , Lu Wenbin , Ma Yilun , Quataert Eliot , Miniutti Giovanni , Chiaberge Marco , Filippenko Alexei V , González Beatriz Agís 
Published: May 2024

ABSTRACT
The origins of quasi-periodic eruptions (QPEs) are poorly understood, although most theoretical explanations invoke an accretion disc around a supermassive black hole. The gas and stellar environments in the galactic nuclei of these sources are also poorly constrained. In this paper, we present an analysis of archival Hubble Space Telescope (HST) images to study the narrow-line [O iii] emission in the QPE source GSN 069. We find strong evidence for a compact nuclear [O iii] emission region of size ≲ 35 pc, overlaid on top of extended [O iii] emission up to 1 kpc away from the nucleus. The age of the accretion system is estimated to be between 10 and 100 yr. The [O iii] luminosity of the compact region was measured to be $(2.1 \pm 0.3) \times 10^{40}\, \rm erg\, s^{-1}$. Based on cloudy simulations, we constrain that the [O iii] emitting gas has a hydrogen number density in the range $2 \times 10^{3} \lt n_{\rm H} \lesssim 10^{8}\, \rm cm^{-3}$ and volume filling factor fV &lt; 4 × 10−3. We suggest that the dense gas in the nuclear region of GSN 069 originates from molecular clouds (with total mass $\gtrsim 3 \times 10^{3}\, {\rm M}_{\odot }$), which are freshly ionized by the soft X-ray photons from the accretion disc. We predict possible evolution of the compact narrow-line region on emission-line diagnostic diagrams, and hence future HST or integral-field unit observations can be used to further pin down the age of this puzzling system.
Wright’s Hierarchical F-Statistics
Authors: Uyenoyama Marcy K 
Published: May 2024

Abstract
This perspective article offers a meditation on FST and other quantities developed by Sewall Wright to describe the population structure, defined as any departure from reproduction through random union of gametes. Concepts related to the F-statistics draw from studies of the partitioning of variation, identity coefficients, and diversity measures. Relationships between the first two approaches have recently been clarified and unified. This essay addresses the third pillar of the discussion: Nei’s GST and related measures. A hierarchy of probabilities of identity-by-state provides a description of the relationships among levels of a structured population with respect to genetic diversity. Explicit expressions for the identity-by-state probabilities are determined for models of structured populations undergoing regular inbreeding and recurrent mutation. Levels of genetic diversity within and between subpopulations reflect mutation as well as migration. Accordingly, indices of the population structure are inherently locus-specific, contrary to the intentions of Wright. Some implications of this locus-specificity are explored.
Quantifying Cigarette and e-Cigarette Marketing Exposure Among Chinese Adolescents Using Ecological Momentary Assessment
Authors: Czaplicki Lauren , Barker Hannah E , Thrul Johannes , Cui Yuxian , Yang Tingzhong , Cohen Joanna E 
Published: May 2024

Abstract

Introduction
Addressing cigarette and e-cigarette use in China is key to reducing the global tobacco epidemic. Marketing exposure is one causal factor for adolescent smoking and e-cigarette use. Currently, China restricts cigarette and e-cigarette ads in public places and online; however, there may not be full policy compliance. We collected real-time data in the natural environment to estimate how much and where Chinese adolescents—a group susceptible to smoking and e-cigarette use—are exposed to cigarette and e-cigarette marketing to inform policy responses.

Aims and Methods
In June 2022, we conducted a 7-day ecological momentary assessment (EMA) study with 15–16-year-olds (n = 96) across eight Chinese cities. Participants completed up to 42 EMA surveys (six per day), sent at random intervals outside of school hours. In each survey, participants reported whether they saw (1) displays and (2) ads in the past hour (none, cigarette, e-cigarette, both) in the past hour. We also captured the source of cigarette/e-cigarette ad exposure.

Results
Most participants were exposed to cigarette and/or e-cigarette displays (89.6%) or ads (79.2%) more than 7 days. On average, participants reported past-hour exposure to displays 12.7 times and past-hour exposure to ads 10.8 times over the week. The most common sources of cigarette ads were public places (eg, kiosks, supermarkets); the most common sources of e-cigarette ad exposure were social media/internet or e-cigarette stores.

Conclusions
Findings highlight the need to enhance enforcement of restrictions on cigarette and e-cigarette ads in public places and online in China and extend restrictions to ban displays.

Implications
Marketing exposure is a causal factor in youth smoking and e-cigarette use. We used EMA to estimate cigarette and e-cigarette display and ad exposure among Chinese adolescents. On average, participants reported past-hour exposure to cigarette and/or e-cigarette displays 13 times and past-hour exposure to cigarette and/or e-cigarette ads 11 times more than 1 week. Most saw ads in public places and online. Results suggest strengthening implementation of China’s ban on cigarette and e-cigarette ads in public places and online and banning product displays. These are policy responses that can contribute to reducing adolescent cigarette and e-cigarette uptake in China.
Development of a mobile, high-throughput, and low-cost image-based plant growth phenotyping system
Authors: Yu Li’ang , Sussman Hayley , Khmelnitsky Olga , Rahmati Ishka Maryam , Srinivasan Aparna , Nelson Andrew D L , Julkowska Magdalena M 
Published: May 2024

Abstract
Nondestructive plant phenotyping forms a key technique for unraveling molecular processes underlying plant development and response to the environment. While the emergence of high-throughput phenotyping facilities can further our understanding of plant development and stress responses, their high costs greatly hinder scientific progress. To democratize high-throughput plant phenotyping, we developed sets of low-cost image- and weight-based devices to monitor plant shoot growth and evapotranspiration. We paired these devices to a suite of computational pipelines for integrated and straightforward data analysis. The developed tools were validated for their suitability for large genetic screens by evaluating a cowpea (Vigna unguiculata) diversity panel for responses to drought stress. The observed natural variation was used as an input for a genome-wide association study, from which we identified nine genetic loci that might contribute to cowpea drought resilience during early vegetative development. The homologs of the candidate genes were identified in Arabidopsis (Arabidopsis thaliana) and subsequently evaluated for their involvement in drought stress by using available T-DNA insertion mutant lines. These results demonstrate the varied applicability of this low-cost phenotyping system. In the future, we foresee these setups facilitating the identification of genetic components of growth, plant architecture, and stress tolerance across a wide variety of plant species.
Molinism's kryptonite: Counterfactuals and circumstantial luck
Authors: Rusavuk Andre Leo 
Published: May 2024

Abstract
According to Molinism, logically prior to his creative decree, God knows via middle knowledge the truth value of the counterfactuals or conditionals of creaturely freedom (CFs) and thus what any possible person would do in any given circumstance. Critics of Molinism have pointed out that the Molinist God gets lucky that the CFs allow him to actualize either a world of his liking or even a good-enough world at all. In this paper, I advance and strengthen the popular critique in two ways. First, I specify the kind of luck to which God is subject, which is circumstantial moral luck. Second, and more importantly, I argue that exposure to this luck is problematic because something external to God and beyond his control determines the degree of praiseworthiness he deserves in relevant possible worlds. My main contention is that divine subjection to circumstantial moral luck raises the theoretical costs of Molinism.
Prognostic Factors and Treatment Effect Modifiers for Physical Health, Opioid Prescription, and Health Care Utilization in Patients With Musculoskeletal Disorders in Primary Care: Exploratory Secondary Analysis of the STEMS Randomized Trial of Direct Access to Physical Therapist–Led Care
Authors: Zouch James , Bhimani Nazim , Bussières André , Ferreira Manuela L , Foster Nadine E , Ferreira Paulo 
Published: May 2024

Abstract

Objective
The aims of the study were to identify prognostic factors associated with health care outcomes in patients with musculoskeletal (MSK) conditions in primary care and to determine whether characteristics associated with choice of care modify treatment effects of a direct-access physical therapist–led pathway in addition to general practitioner (GP)–led care compared to GP-led care alone.

Methods
A secondary analysis of a 2-parallel-arm, cluster randomized controlled trial involving general practices in the United Kingdom was conducted. Practices were randomized to continue offering GP-led care or to also offer a direct-access physical therapist–led pathway. Data from adults with MSK conditions who completed the 6-month follow-up questionnaire were analyzed. Outcomes included physical health, opioid prescription, and self-reported health care utilization over 6 months. Treatment effect modifiers were selected a priori from associations in observational studies. Multivariable regression models identified potential prognostic factors, and interaction analysis tested for potential treatment effect modifiers.

Results
Analysis of 767 participants indicated that baseline pain self-efficacy, pain severity, and having low back pain statistically predicted outcomes at 6 months. Higher pain self-efficacy scores at baseline were associated with improved physical health scores, reduced opioid prescription, and less health care utilization. Higher bodily pain at baseline and having low back pain were associated with worse physical health scores and increased opioid prescription. Main interaction analyses did not reveal that patients’ age, level of education, duration of symptoms, or MSK presentation influenced response to treatment, but visual trends suggested those in the older age group proceeded to fewer opioid prescriptions and utilized less health care when offered direct access to physical therapy.

Conclusions
Patients with MSK conditions with lower levels of pain self-efficacy, higher pain severity, and presenting with low back pain have less favorable clinical and health care outcomes in primary care. Prespecified characteristics did not modify the treatment effect of the offer of a direct-access physical therapist–led pathway compared to GP-led care.

Impact
Patients with MSK conditions receiving primary care in the form of direct-access physical therapist–led or GP-led care who have lower levels of self-efficacy, higher pain severity, and low back pain are likely to have a less favorable prognosis. Age and duration of symptoms should be explored as potential patient characteristics that modify the treatment response to a direct-access physical therapist–led model of care.
Increased prevalence of malignancies in patients with IgG4-related disease: implications for clinical care
Authors: Keller-Sarmiento Luca , Viapiana Naomi , Lanzillotta Marco , Batani Veronica , Mahajne Jasmin , Dagna Lorenzo , Della-Torre Emanuel 
Published: May 2024

Abstract

Objectives
The association between cancer and IgG4-related disease (IgG4-RD) is evolving. The primary aim of this study was to investigate the prevalence of malignancies in IgG4-RD. The secondary aim was to describe the epidemiological and clinical characteristics of IgG4-RD patients with a history of cancer.

Methods
Two hundred and ten patients with IgG4-RD were included in this retrospective study. IgG4-RD phenotypes, clinical and serological variables were analysed. The prevalence of cancer in IgG4-RD was compared with that in the Italian population using the registry of the Global Cancer Observatory (GCO) of the World Health Organization. The Standardized Incidence Ratio (SIR) for cancer in IgG4-RD was obtained based on the 5-year Limited Duration Prevalence (2015–2020) of tumours in the Italian population.

Results
Thirty-seven/210 patients (18%) developed cancer before or after the diagnosis of IgG4-RD. Solid and haematologic tumours were more frequently observed in pancreato-biliary IgG4-RD. The SIR for malignancy in IgG4-RD patients was 2.54 higher than the general Italian population (P = 0.007). The SIR was 2.78 higher for males (P = 0.005) and 1.15 higher for females (P &gt; 0.05). Thirty-two malignancies were diagnosed before and 16 after IgG4-RD diagnosis. Interval ‘from IgG4-RD to cancer’ was shorter than that ‘from cancer to IgG4-RD’. Most tumours occurring after IgG4-RD developed within 36 months from diagnosis of IgG4-RD.

Conclusions
The prevalence of cancer in patients with IgG4-RD is increased compared with the Italian population and mechanistically suggests a possible paraneoplastic association. Close surveillance is warranted for the first 36 months after IgG4-RD diagnosis.
Combination of cytoplasmic and nuclear patterns on Hep-2 antinuclear antibody is useful as a screening test for anti-synthetase syndrome
Authors: Yoshida Katsuyuki , Takahashi Soshi , Kawai Ryota , Saito Toshiharu , Hatachi Saori , Shintani Ayumi , Sugawara Hitoshi , Kumagai Shunichi 
Published: May 2024

Abstract

Objective
This study aimed to establish a screening model for differentiating anti-synthetase syndrome (ASS) from other ANA-associated rheumatic diseases (AARDs) using a combination of cytoplasmic and non-cytoplasmic ANA (ncANA) patterns.

Methods
: This retrospective observational study included patients with AARDs such as SLE, SSc, SS, MCTD and PM/DM who underwent ANA screening between April 2012 and December 2021. Variables included age, sex, ANA patterns (Cytoplasmic and ncANA) and titres. Logistic regression analysis of Cytoplasmic and ncANA patterns was performed to differentiate ASS from other AARDs.

Result
: The 981 diagnosed cases of AARDs consisted of SS (n = 451), SSc (n = 264), SLE (n = 201), PM/DM (n = 104), MCTD (n = 52) and ASS, including PM/DM (n = 64). Of these, 155 patients had ≥2 overlapping diseases; however, there was no overlap between AARDs and ASS. ASS is more likely to occur when the cytoplasmic titre is positive and the ncANA &lt;320. Receiver operating characteristic analysis of the Cytoplasmic and ncANA range revealed an area under the receiver operating characteristic curve of 0.885 (95% CI: 0.844–0.927).

Conclusion
: It is important to detect cytoplasmic patterns as an ANA screening test for ASS diagnosis, even if the titre is low. Additionally, combining the cytoplasmic and ncANA patterns yields more accurate ASS screening results.
Educative Psychological Treatment at Edinburgh’s Royal Asylum: Unfolding The Morningside Mirror, 1845–1882
Authors: Holligan Christopher 
Published: May 2024

Summary
This article examines moral therapy in relation to writing by fee-paying ‘lunatic’ asylum patients from the upper and middle classes. Their work was published in a nineteenth-century monthly periodical, The Morningside Mirror. There is an intersection of the periodical with status and the interests of gentlemanly values. Despite their psychopathological diagnoses, which included melancholia, writers for the Mirror retained their human capacity to share poignant insights into love and social injustice. Edinburgh’s reputation as a cultural and scientific centre of learning provided opportunities for the asylum to market itself as an iconic sanctuary that could maintain the materially privileged lifestyles of patients. The Morningside Mirror offered creative activity, self-esteem maintenance and public recognition. It connected the Asylum to the society outside. The expression of logic as reflective of the repair of reason signalled, from the viewpoint of psychological medicine, the Mirror’s therapeutic impact and utility to project reputation.