bluuebunny/crossref_metadata_2025_split huggingface dataset:
Deep brain stimulation of the subthalamic nucleus improves sense of well‐being in parkinson's disease
Authors: McDonald Louise M. , Page Donna , Wilkinson Leonora , Jahanshahi Marjan 
Published: January 2012

AbstractDeep brain stimulation of the subthalamic nucleus is an effective treatment for the motor symptoms of Parkinson's disease. Although a range of psychiatric and behavioral problems have been documented following deep brain stimulation, the short‐term effects of subthalamic nucleus stimulation on patients' mood have only been investigated in a few studies. Our aim was to compare self‐reported mood in Parkinson's patients with deep brain stimulation of the subthalamic nucleus ON versus OFF. Twenty‐three Parkinson's patients with bilateral deep brain stimulation of the subthalamic nucleus and 11 unoperated Parkinson's patients completed a mood visual analogue scale twice. Operated patients were tested with deep brain stimulation of the subthalamic nucleus both ON and OFF. All were assessed on medication. The operated Parkinson's group reported feeling significantly better coordinated, stronger, and more contented with deep brain stimulation ON compared to OFF. Fourteen of the 16 mood scales changed in a positive direction when deep brain stimulation of the subthalamic nucleus was ON. When changes in motor scores were taken into account, the operated patients still reported feeling better‐coordinated, but also less gregarious with stimulation ON. Unoperated Parkinson's patients showed no differences on any of these measures between their 2 ratings. Short‐term changes in deep brain stimulation of the subthalamic nucleus have a small and mostly positive effect on mood, which may be partly related to improvements in motor symptoms. The implications for day‐to‐day management of patients with deep brain stimulation of the subthalamic nucleus are discussed. © 2012 Movement Disorder Society
Concordance with Guideline Recommendations: previous and more recent Nonsteroidal anti‐inflammatory Drug prescriptions in Quebec, Canada
Authors: Rahme Elham , Roussy Jean‐Pascal , Lafrance Jean‐Philippe , Nedjar Hacene , Morin Suzanne 
Published: January 2012

ABSTRACTBackgroundClinical practice guidelines for appropriate nonsteroidal anti‐inflammatory drug (NSAID) utilisation focus on preventing NSAID‐related gastrointestinal (GI), cardiovascular (CV), congestive heart failure (CHF) and renal adverse events. We compared concordance of NSAID prescriptions with clinical practice guideline recommendations in Quebec, pre and post rofecoxib withdrawal from market.MethodsData were obtained from the Quebec Health Insurance Agency (RAMQ). All prescriptions for celecoxib and traditional NSAIDs (tNSAIDs) dispensed to patients ≥50 years of age were evaluated for concordance with clinical practice guidelines. Prescriptions were stratified by time period (pre and post rofecoxib withdrawal) and, GI, CV, CHF and renal risk factors at the dispensing date. Gastro‐protective agent (GPA) co‐prescriptions were also evaluated.ResultsWe assessed 1,966,793 celecoxib and 1,743,481 tNSAIDs prescriptions. Of celecoxib prescriptions, 87.2% and 86.5% were appropriate in the post‐ and pre‐periods, respectively, compared to 72.6% and 70.1% of tNSAIDs prescriptions, respectively. In logistic regression, ‘appropriateness’ of celecoxib prescriptions increased with age, rheumatoid arthritis and osteoarthritis (OA), and was higher in the post‐ versus pre‐period (odds ratio 1.22, 95% confidence interval 1.18–1.26); it was lower in women and in patients with higher income. ‘Appropriateness’ of tNSAID prescriptions decreased in the post‐period (0.92, 0.89–0.95), was lower in older persons and those with OA, and higher in women and in higher income patients. Of tNSAID prescriptions that should have received a GPA co‐prescription, only 45.6% did.ConclusionConcordance with guideline recommendations increased for celecoxib and decreased for tNSAIDs after rofecoxib withdrawal; GPA co‐prescription with tNSAIDs remained suboptimal. Copyright © 2012 John Wiley & Sons, Ltd.
The interactome of LIM domain proteins: The contributions of LIM domain proteins to heart failure and heart development
Authors: Li Amy , Ponten Fredrik , dos Remedios Cristobal G. 
Published: January 2012

AbstractLIM domain proteins all contain at least one double zinc‐finger motif. They belong to a large family and here we review those expressed mainly in mammalian hearts, but particularly in cardiomyocytes. These proteins contain between one and five LIM domains and usually these proteins contain other domains that have specific functions such as actin‐binding, kinases and nuclear translocation motifs. While several recent reviews have summarised the importance of individual LIM domain proteins, this is the first review of its kind to cover all LIMs associated with the heart. Here we examine 33 LIM proteins (including three that bind to, but do not themselves contain, LIM domains) that are implicated in either the development of the heart, heart disorders and failure, or both. Our analysis is consistent with the view that cardiac LIM domain proteins form multiple extensive networks of multi‐protein complexes within the myocardium. This multiplicity of binding partners probably protects the heart as it is challenged to maintain cardiac output, until the imbalance reaches a turning point that results in failure. We believe that the complexity of LIM interactions is properly described by the term LIM interactome.
Open‐label, follow‐on study of azithromycin in pediatric patients with CF uninfected with Pseudomonas aeruginosa
Authors: Saiman Lisa , Mayer‐Hamblett Nicole , Anstead Michael , Lands Larry C. , Kloster Margaret , Goss Christopher H. , Rose Lynn M. , Burns Jane L. , Marshall Bruce C. , Ratjen Felix ,   the AZ0004 Macrolide Study Team
Published: January 2012

AbstractBackgroundWe previously performed a randomized placebo‐controlled trial to examine the effects of azithromycin in children and adolescents 6–18 years of age with cystic fibrosis uninfected with Pseudomononas aeruginosa and demonstrated that while azithromycin did not acutely improve pulmonary function, azithromycin‐reduced pulmonary exacerbations, decreased the initiation of new oral antibiotics, and improved weight gain. We now report the results of the open‐label, follow‐on study to assess durability of response to azithromycin and continued safety and tolerability.MethodsEligible participants were enrolled in a 24‐week open‐label study of azithromycin to compare efficacy and safety endpoints during the placebo‐controlled trial versus open‐label study in two groups: participants initially on azithromycin continued azithromycin (azithromycin–azithromycin) and participants initially on placebo who then received azithromycin (placebo–azithromycin). As in the placebo‐controlled trial, the azithromycin dose in the open‐label study was 250 mg Monday–Wednesday–Friday for participants weighing 18–35.9 kg and 500 mg Monday–Wednesday–Friday for participants weighing 36 kg or greater.ResultsOf 174 eligible participants, 146 (83.9%) enrolled in the open‐label study. No significant improvements in lung function were observed within either group. There were no differences in outcomes in the placebo–azithromycin group during the placebo‐controlled versus open‐label phase. The azithromycin–azithromycin group had comparable odds of experiencing an exacerbation during the two phases (OR 1.6, CI95 0.8, 3.0) and stable weight gain, but new oral antibiotics were initiated more frequently during the open‐label study (OR 1.9, CI95 1.0, 3.5). In both groups, adverse event rates were comparable during the placebo‐controlled and open‐label study and treatment‐emergent pathogens were rare.ConclusionsDuring the open‐label study, we observed continued durability of treatment response to azithromycin, as measured by pulmonary exacerbations and continued weight gain, although use of oral antibiotics increased. There were no new safety concerns. Currently available data suggest that azithromycin reduces exacerbations and improves weight gain for 6–12 months among children and adolescents with CF uninfected with P. aeruginosa. Pediatr Pulmonol. 2012; 47:641–648. © 2012 Wiley Periodicals, Inc.
Comparison of quantitative sweat chloride methods after positive newborn screen for cystic fibrosis
Authors: Laguna Theresa A. , Lin Nan , Wang Qi , Holme Bonnie , McNamara John , Regelmann Warren E. 
Published: January 2012

AbstractObjectivesRapid and reliable confirmatory sweat testing following a positive newborn screen (NBS) for cystic fibrosis (CF) is preferred to allow for early diagnosis and to decrease parental anxiety. The Cystic Fibrosis Foundation (CFF) recently recommended a quantity not sufficient (QNS) rate of ≤10% in infants <3 months of age referred for quantitative sweat chloride analysis. Two CFF‐approved methods are available by which to quantitatively measure chloride concentration in sweat. Our objective was to compare the performance of the Macroduct® sweat collection system (MSCS) with the Gibson and Cooke technique (GCT) in the acquisition of samples for the determination of sweat chloride concentration in infants with a positive Minnesota State NBS for CF.MethodsA retrospective database review of infants referred to the core Minnesota CF Center or its affiliate site for confirmatory sweat testing was performed to compare the QNS rates for the two techniques. Associations between birthweight, age at test, race, and QNS rates were examined.ResultsFive hundred sixty‐eight infants were referred for 616 sweat tests from March 2006 to January 2010. The mean age was 32.8 days at the initial sweat test. The GCT had a significantly higher QNS rate compared to the MSCS (15.4% vs. 2.1%, P < 0.0001). There was no association between age and the probability of QNS. The probability of QNS decreased as birthweight increased (P = 0.02). After adjusting for age, the odds of QNS using the GCT remained 8.34 (95% CI: 3.72–18.71) times that of the MSCS. Non‐White infants had a significantly higher likelihood of QNS compared to non‐Hispanic White infants (P = 0.0025).ConclusionsGiven the performance of the MSCS, the Minnesota CF Center has implemented the MSCS as its method of choice for diagnostic sweat testing in infants following a positive state NBS. Pediatr Pulmonol. 2012. 47:736–742. © 2012 Wiley Periodicals, Inc.
Automatic selection of reference taxa for protein–protein interaction prediction with phylogenetic profiling
Authors: Simonsen Martin , Maetschke Stefan R. , Ragan Mark A. 
Published: January 2012

Abstract
Motivation: Phylogenetic profiling methods can achieve good accuracy in predicting protein–protein interactions, especially in prokaryotes. Recent studies have shown that the choice of reference taxa (RT) is critical for accurate prediction, but with more than 2500 fully sequenced taxa publicly available, identifying the most-informative RT is becoming increasingly difficult. Previous studies on the selection of RT have provided guidelines for manual taxon selection, and for eliminating closely related taxa. However, no general strategy for automatic selection of RT is currently available.
Results: We present three novel methods for automating the selection of RT, using machine learning based on known protein–protein interaction networks. One of these methods in particular, Tree-Based Search, yields greatly improved prediction accuracies. We further show that different methods for constituting phylogenetic profiles often require very different RT sets to support high prediction accuracy.
Availability: The datasets and software used in the experiments can be found at http://users-birc.au.dk/zxr/phyloprof/
Contact: zxr@birc.au.dk; somme89@gmail.com
Supplementary information: Supplementary data are available at Bioinformatics online.
NetSeed: a network-based reverse-ecology tool for calculating the metabolic interface of an organism with its environment
Authors: Carr Rogan , Borenstein Elhanan 
Published: January 2012

Abstract
Summary: NetSeed is a web tool and Perl module for analyzing the topology of metabolic networks and calculating the set of exogenously acquired compounds. NetSeed is based on the seed detection algorithm, developed and validated in previous studies.
Availability: The NetSeed web-based tool, open-source Perl module, examples and documentation are freely available online at: http://depts.washington.edu/elbogs/NetSeed.
Contact: elbo@uw.edu
Australian mental health consumers’ priorities for research: Qualitative findings from the SCOPE for Research project
Authors: Banfield Michelle A. , Barney Lisa J. , Griffiths Kathleen M. , Christensen Helen M. 
Published: January 2012

AbstractBackground  There is growing acceptance of the importance of the consumer viewpoint in mental health research. Previous studies have identified differences in research priorities between researchers and mental health consumers in Australia defined broadly. However, little is known about the research priorities of consumers with specific mental health conditions.Objective  The aim of this study was to explore Australian mental health consumers’ priorities for depression and bipolar disorder research.Design  Focus groups with consumers and individual telephone interviews with consumer advocates. Participants were asked to discuss the topics they believed were priorities for depression or bipolar disorder research. Transcripts were thematically analysed using NVivo 7.Setting and Participants  Ten people with depression and 19 with bipolar disorder participated in face‐to‐face focus groups held in three Australian capital cities. Five participants with each disorder participated in online focus groups. Five Australian consumer advocates with experience of depression and six with experience of bipolar disorder were individually interviewed by telephone.Results  Participants raised a broad variety of topics for research. The most salient themes included the need for research on medication, and lifestyle and psychosocial influences on depression and bipolar disorder.Conclusions  Participants’ priorities reflect an interest in a holistic approach to mental health research that examines the influences of everyday life and psychosocial influences both on the development and on the management of these disorders. Their focus was on research that explores individualized care and the active role that consumers can play in their own care and recovery.
Parental Risk Attitudes and Children's Academic Test Scores: Evidence from the US Panel Study of Income Dynamics
Authors: Brown Sarah , Ortiz‐Nuñez Aurora , Taylor Karl 
Published: January 2012

AbstractUsing a sequence of questions from the 1996 US Panel Study of Income Dynamics (PSID), we explore the implications of interpersonal differences in parent's attitudes towards risk for the academic test scores of their children focusing on information drawn from the 1997 Child Development Supplement of the PSID. In addition, we explore whether parental risk preference influences whether the child subsequently attends college. Our findings suggest that a parent's degree of risk aversion is inversely related to the academic test scores of their children as well as being inversely related to the probability of attending college post high school.
Engaging Diversity in Teaching Religion and Theology: An Intercultural, De‐colonial Epistemic Perspective
Authors: Andraos Michel Elias 
Published: January 2012

AbstractThis essay explores new ways of engaging diversity in the production of knowledge in the classroom using coloniality as an analytical lens. After briefly engaging some of the recent literature on coloniality, focusing on the epistemic dimension, the author uses the example of teaching a course on religion, culture, and theology, where he employs this analysis, to develop a new pedagogical approach as a step towards an intercultural, de‐colonial theological education.
How word frequency modulates masked repetition priming: An ERP investigation
Authors: Grainger Jonathan , Lopez Danielle , Eddy Marianna , Dufau Stéphane , Holcomb Phillip J. 
Published: January 2012

AbstractThe present study used event‐related potentials (ERPs) to provide precise temporal information about the modulation of masked repetition priming effects × word frequency during the course of target word recognition. Contrary to the pattern seen with behavioral response times in prior research, we predicted that high‐frequency words should generate larger and earlier peaking repetition priming effects than low‐frequency words in the N400 time window. This prediction was supported by the results of two experiments. Furthermore, repetition priming effects in the N250 time window were found for low‐frequency words in both experiments, whereas for high‐frequency words these effects were seen only at the shorter (50 ms stimulus onset asynchrony [SOA]) used in Experiment 2, and not in Experiment 1 (70 ms SOA). We explain this pattern as resulting from reset mechanisms operating on the form representations activated by prime stimuli when primes and targets are processed as separate perceptual events.
Integrating multidirectional connectivity requirements in systematic conservation planning for freshwater systems
Authors: Hermoso Virgilio , Kennard Mark J. , Linke Simon 
Published: January 2012

AbstractAim Recent efforts to apply the principles of systematic conservation planning to freshwater ecosystems have focused on the special connected nature of these systems as a way to ensure adequacy (long‐term maintenance of biodiversity). Connectivity is important in maintaining biodiversity and key ecological processes in freshwater environments and is of special relevance for conservation planning in these systems. However, freshwater conservation planning has focused on longitudinal connectivity requirements within riverine ecosystems, while other habitats, such as floodplain wetlands or lakes and connections among them, have been overlooked. Here, we address this gap by incorporating a new component of connectivity in addition to the traditional longitudinal measure.Location Northern Australia.Methods We integrate lateral connections between freshwater areas (e.g. lakes and wetlands) that are not directly connected by the river network and the longitudinal upstream–downstream connections. We demonstrate how this can be used to incorporate ecological requirements of some water‐dependent taxa that can move across drainage divides, such as waterbirds.Results When applied together, the different connectivity rules allow the identification of priority areas that contain whole lakes or wetlands, their closest neighbours whenever possible, and the upstream/downstream reaches of rivers that flow into or from them. This would facilitate longitudinal and lateral movements of biota while minimizing the influence of disturbances potentially received from upstream or downstream reaches.Main conclusions This new approach to defining and applying different connectivity rules can help improve the adequacy of freshwater‐protected areas by enhancing movements of biodiversity within priority areas. The integration of multiple connectivity needs can also serve as a bridge to integrate freshwater and terrestrial conservation planning.
Mutant HrasG12V and KrasG12D have overlapping, but non‐identical effects on hepatocyte growth and transformation frequency in transgenic mice
Authors: Figueiredo Marxa L. , Stein Timothy J. , Jochem Adam , Sandgren Eric P. 
Published: January 2012

AbstractBackgroundMouse hepatocarcinogenesis is associated with mutations in Hras, but infrequently in Kras. The effect on carcinogenesis of developmental age at the time of ras mutation remains unknown.AimWe sought to compare quantitatively the effects of expressing mutant H‐ or Kras genes in fetal vs. adult mouse liver.MethodsWe established an inducible system of gene expression in mouse liver to define disease pathogenesis associated with activation of oncogene expression.ResultsDiffuse expression of either oncogene in fetal or adult hepatocytes caused hepatomegaly. For mutant HrasG12V, this phenotype was almost fully reversible and accompanied by apoptosis, indicating that maintenance of hepatomegaly requires continuous HrasG12V expression. We also examined the effect of ras expression on growth of transplanted hepatocytes in an in vivo system that allows us to quantify hepatocyte growth effects in both permissive and restrictive hepatic growth environments. Mutant KrasG12D had no effect on hepatocyte growth in this system. In contrast, HrasG12V induced increased hepatocyte focus growth in quiescent liver, the hallmark of a cell autonomous growth stimulus. HrasG12V also increased the fraction of donor hepatocyte foci that displayed extreme growth, a characteristic of preneoplastic lesions.ConclusionsThe primary effect of diffuse, whole‐liver expression of either mutant ras gene in fetal or adult mouse liver is diffuse and progressive hepatic growth. HrasG12V mutation influences hepatocarcinogenesis by conferring cell autonomous growth potential upon foci of expressing cells and by increasing the risk of neoplastic progression. KrasG12D does not share these latter carcinogenic effects in mouse liver.
Natural History of Helicobacter pylori Infection in Childhood: Eight‐Year Follow‐Up Cohort Study in an Urban Community in Northeast of Brazil
Authors: Queiroz Dulciene M. , Carneiro Jessica G. , Braga‐Neto Manuel B. , Fialho Andrea B. C. , Fialho Andre M. , Goncalves Maria H. B. , Rocha Gifone A. , Rocha Andreia M. C. , Braga Lucia L. B. 
Published: January 2012

AbstractBackground:  Helicobacter pylori infection is acquired predominantly in childhood. There is also evidence that children loss the infection. Therefore, factors that account for children remain infected need to be investigated because once established the infection persists throughout the life unless treated.Methods:  This study aimed to evaluate the H. pylori infection in children of a low‐income community at baseline and 8 years later to determine the predictor factors linked to the maintenance, acquisition, and loss of the infection using regression models of generalized estimating equations. H. pylori status was determined by 13C‐urea breath test.Results:  Data from 37.7% (133/353) of the children were available. No difference between the characteristics of the included and nonincluded children was observed. The prevalence of infection increased from 53.4 to 64.7%. Thirty‐nine children (29.3%) remained noninfected, 47.4% remained infected, 17.3% became infected, and 6.0% lost the infection. Factors associated with to remain infected compared with to remain noninfected included the age, increased number of children in the household, and the use of well water instead of municipal water. The acquisition of the infection was associated with the male gender.Conclusion:  Factors linked to remain and to gain H. pylori infection in a poor region were increased number of children in the household and the male gender. Also, the acquisition rates were higher than the loss rates, which lead to an increase in the infection prevalence with age.