bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hydrogen‐Bond Dynamics of CH⋅⋅⋅O Interactions: The Chloroform⋅⋅⋅Acetone Case
Authors: Vaz Pedro D. , Nolasco Mariela M. , Gil Francisco P. S. C. , Ribeiro‐Claro Paulo J. A. , Tomkinson John 
Published: July 2010

AbstractSpectroscopic evidence for CH⋅⋅⋅O hydrogen bonding in chloroform⋅⋅⋅acetone [Cl3CH⋅⋅⋅OC(CH3)2] mixtures was obtained from vibrational inelastic neutron scattering (INS) spectra. Comparison between the INS spectra of pure samples and their binary mixtures reveals the presence of new bands at about 82, 130 and 170 cm−1. Assignment of the 82 cm−1 band to the νO⋅⋅⋅H anti‐translational mode is considered and discussed. In addition, the βCH mode of CHCl3 at 1242 cm−1 is split in the spectra of the mixtures, and the high‐wavenumber component is assigned to the hydrogen‐bonded complex. The plot of the integrated intensity of this component shows a maximum for x=0.5, in agreement with the 1:1 stoichiometry of the chloroform⋅⋅⋅acetone complex, with a calculated complexation constant of 0.15 dm3 mol−1. Results also show that the complex behaves as an independent entity, that is, despite being weak, such interactions play a key role in supramolecular chemistry.
Chemistry and Biology of the Caged Garcinia Xanthones
Authors: Chantarasriwong Oraphin , Batova Ayse , Chavasiri Warinthorn , Theodorakis Emmanuel A. 
Published: July 2010

AbstractNatural products have been a great source of many small molecule drugs for various diseases. In spite of recent advances in biochemical engineering and fermentation technologies that allow us to explore microorganisms and the marine environment as alternative sources of drugs, more than 70 % of the current small molecule therapeutics derive their structures from plants used in traditional medicine. Natural‐product‐based drug discovery relies heavily on advances made in the sciences of biology and chemistry. Whereas biology aims to investigate the mode of action of a natural product, chemistry aims to overcome challenges related to its supply, bioactivity, and target selectivity. This review summarizes the explorations of the caged Garcinia xanthones, a family of plant metabolites that possess a unique chemical structure, potent bioactivities, and a promising pharmacology for drug design and development.
Solid‐Phase Synthesis of Lipidated Ras Peptides Employing the Ellman Sulfonamide Linker
Authors: Triola Gemma , Gerauer Marc , Görmer Kristina , Brunsveld Lucas , Waldmann Herbert 
Published: July 2010

AbstractA detailed study on the solid‐phase synthesis of lipidated peptides of the Ras family employing the Ellman sulfonamide linker is reported. Using the C‐terminal N‐Ras sequence, critical issues such as lipidated amino acid resin loading, peptide elongation in the presence of labile groups and optimized conditions for release of the peptides were investigated. A versatile methodology for the synthesis of peptides with diverse lipid motifs and C‐terminal methyl esters has accordingly been established.
Crisis management in information system projects: lessons of a case study
Authors: Chartier Anne , Banville Claude , Landry Maurice 
Published: July 2010

AbstractThis case study is reflective of the action‐research perspective documents applied in an intervention to manage a crisis during an information technology development project. The aim was to better understand how tools used to solve unstructured problems might help resolve such crises. The development and implementation of an intervention utilizing multiple tools is described. As a result of the intervention, a shared meaning of the crisis emerged among the major stakeholders along with a consensus as to appropriate solutions and action steps. Work on the project resumed to the satisfaction of management. Recommendations for future research are offered. Copyright © 2010 ASAC. Published by John Wiley & Sons, Ltd.
Oxygen Reduction Reaction at Three‐Phase Interfaces
Authors: Subbaraman Ram , Strmcnik Dusan , Paulikas Arvydas P. , Stamenkovic Vojislav R. , Markovic Nenad M. 
Published: July 2010

AbstractThe kinetics of the oxygen reduction reaction (ORR) is studied at metal–supporting electrolyte–Nafion three‐phase interfaces. We first demonstrate that the sulfonate anions of Nafion are specifically adsorbed on a wide range of surfaces ranging from Pt(hkl) single‐crystal surfaces, Pt‐poly, Pt‐skin [produced on a Pt3Ni(111) surface by annealing in ultrahigh vacuum, UHV] to high‐surface‐area nanostructured thin‐film (NSTF) catalysts. The surface coverage by sulfonate and the strength of the Pt–sulfonate interaction are strongly dependent on the geometry and the nature of the Pt surface atoms. Also, they are found to behave analogous to (bi)sulfate anion‐specific adsorption on these surfaces, where for the Pt(hkl) surfaces, the trend is Pt(111)>Pt(110)>Pt(100) and for the Pt‐skin surface on Pt3Ni(111), the interaction strength is found to be Pt‐skin<Pt(111). We also found that irrespective of the surface orientation and/or the electronic properties of the surface atoms, the ORR is always inhibited by the presence of ionomers at the electrode surface, confirming that Nafion is not a non‐adsorbing electrolyte. Finally, the knowledge gained from studying well‐defined Pt(hkl) surfaces is applied to propose that deactivation of the ORR on Nafion‐covered high‐surface‐area catalysts is also controlled by specific adsorption of sulfonate anions.
Mining and stakeholder engagement discourse in a Papua New Guinea mine
Authors: Kepore Kevin P. , Imbun Benedict Y. 
Published: July 2010

AbstractIn recent history, corporate social responsibility (CSR) has become synonymous with large business organizations' philanthropic contributions to society. Obviously in the mining industry, because of the nature of its activities in affecting both environment and people, the demand for this voluntary activity from multinational mining companies (MNMCs) by society has become inevitable. This function of CSR had been achieved through the utilization of community engagement discourse with external communities. The main purpose, amongst others, of this paper is to assess the effectiveness of Papua New Guinea (PNG) Ok Tedi mine's community engagement discourse in responding to local community development demands in compensation for adverse environmental impact in its riverine area. It will highlight the critical significance of community engagement discourse as a prime mover in facilitating the achievement of corporate social responsible development projects or lack of it pertaining to a group of mine‐affected riverine local community in PNG. Copyright © 2010 John Wiley & Sons, Ltd and ERP Environment.
Genetic network programming with intron‐like nodes
Authors: Mabu Shingo , Chen Yan , Eto Shinji , Shimada Kaoru , Hirasawa Kotaro 
Published: July 2010

AbstractRecently, genetic network programming (GNP), an extension of the genetic algorithm (GA) and genetic programming (GP), has been proposed. GNP can make compact programs and can memorize the past history implicitly, because it expresses the solution by directed graphs and therefore can reuse the nodes. In this research, intron‐like nodes are introduced for improving the performance of GNP. The aim of introducing intron‐like nodes is to use every node as much as possible. It is found from simulations that intron‐like nodes are useful for improving the training speed and generalization ability. © 2010 Wiley Periodicals, Inc. Electron Comm Jpn, 93(8): 23–31, 2010; Published online in Wiley InterScience (www.interscience. wiley.com). DOI 10.1002/ecj.10259
A new sensorless vector control method using high‐order filters with speed‐varying bandwidth for permanent magnet synchronous motors
Authors: Shinnaka Shinji 
Published: July 2010

AbstractThis paper proposes a new rotor phase estimation method for sensorless drive of permanent‐magnet synchronous motors (PMSMs), which uses the motor‐driving stator voltage and current information for estimation. The proposed estimation method utilizes two high‐order low‐pass filters that can change their bandwidth according to the speed estimate. The high‐order filters are potentially able to attenuate sufficiently the harmonics contaminating the stator voltage and current and to produce an almost pure‐sinusoidal rotor flux estimate consisting of only the fundamental component. Such a sinusoidal rotor flux estimate allows highly accurate estimation of the rotor phase even at very low speed. In order to separate the fundamental component of the rotor flux estimate from its harmonics with no phase lag/lead in variable‐speed environments, the proposed low‐pass filters have the capability to change the bandwidth adaptively to the rotor speed. The sensorless drive system using the proposed phase estimation method has several strong capabilities: (1) it can start up PMSMs from standstill at the rated load; (2) it can drive PMSMs stably even at very low speed, such as 1/60 of the rated speed under the rated motoring/regenerating load; (3) it can drive PMSMs accompanied with an inertial load factor of over 50. The proposed estimation method is simple and easily installed into sensorless drive systems. This paper presents the new estimation method in detail and shows how it is installed into the drive systems by using a concrete example. The usefulness of the method and the performance of the drive system are examined and confirmed through extensive experiments. © 2010 Wiley Periodicals, Inc. Electron Comm Jpn, 93(8): 1–14, 2010; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/ecj.10286
Acquisition of regulatory function by human CD8+ T cells treated with anti‐CD3 antibody requires TNF
Authors: Ablamunits Vitaly , Bisikirska Brygida , Herold Kevan C. 
Published: July 2010

AbstractAnti‐CD3 mAb can modulate graft rejection and attenuate autoimmune diseases but their mechanism(s) of action remain unclear. CD8+ T cells with regulatory function are induced in vitro by Teplizumab, a humanized anti‐CD3 antibody and inhibit responses of autologous and allogeneic T cells. They inhibit CD4+ T‐cell proliferation by mechanisms involving TNF and CCL4, and by blocking target cell entry into G2/M phase of cell cycle but neither kill them, nor compete for IL‐2. CD8+ Treg can be isolated from peripheral blood following treatment of patients with Type 1 diabetes with Teplizumab, but not from untreated patients. The induction of CD8+ Treg by anti‐CD3 mAb requires TNF and signaling through the NF‐κB cascade. The CD8+ Treg express CD25, glucocorticoid‐induced TNF receptor family, CTLA‐4, Foxp3, and TNFR2, and the combined expression of TNFR2 and CD25 identifies a potent subpopulation of CD8+ Treg. These studies have identified a novel mechanism of immune regulation by anti‐CD3 mAb and markers that may be used to track inducible CD8+ Treg in settings such as chronic inflammation or immune therapy.
Polyfunctional T cells in human tuberculosis
Authors: Wilkinson Katalin A. , Wilkinson Robert J. 
Published: July 2010

AbstractStudies of chronic viral infections have highlighted the phenotypic and functional heterogeneity of antigen‐specific T cells and suggested that polyfunctional T cells that secrete multiple cytokines and are able to proliferate on encounter with antigen are more likely than single cytokine secretors to represent correlates of protective immunity. These findings have prompted the evaluation of such T–cell responses in chronic bacterial infections, such as tuberculosis (TB). A number of studies in humans suggested that polyfunctional T cells may indeed be involved in mediating protection in TB; however, studies that question these findings are also emerging, including a study published in this issue of the European Journal of Immunology. These differing findings highlight the difficulties of studying human immunity to TB and the need for polyfunctional T cells to be evaluated in longitudinal studies as opposed to case‐control analyses.
Characterizing follicular dendritic cells: A progress report
Authors: Aguzzi Adriano , Krautler Nike J. 
Published: July 2010

AbstractIn 1965, Mitchell and Abbot (Mitchell, J. and Abbot A, Nature 1965. 30: 500–502) discovered peculiar cells with filiform processes, which were capable of capturing and retaining antigens within secondary lymphoid organs. Yet half a century since the first description of follicular dendritic cells (FDC), their function and their histogenesis remain largely mysterious. FDC are thought to help with organization of the lymphoid follicles, to facilitate the germinal center reaction by presenting antigen to B cells, and to legislate the engulfment of apoptotic bodies, but it has proved difficult to stringently verify any of these functions. One reason for such slow progress is a dearth of markers specific to FDC and their precursors, which limits our ability to isolate, target, and follow FDC. Here we review the current state of FDC science with specific reference to a study in this issue of the European Journal of Immunology and its efforts in discovering new FDC markers.
Oxygenated metabolites of polyunsaturated fatty acids: Formation and function in blood and vascular cells
Authors: Lagarde Michel 
Published: July 2010

AbstractUnsaturated fatty acids esterified in glycerophospholipids are abundant components of cell membranes. They can be released by phospholipases, and subsequently converted into oxygenated derivatives by diverse cyclooxygenase, lipoxygenase and/or cytochrome P450 enzymes. The best known products, i.e. prostanoids, hydroxylated dienes, trienes, and tetraenes, as well as epoxides, are frequently released and act on blood and vascular cells. The present paper briefly reviews these different aspects, pointing out recent developments in the field of docosanoids produced from docosahexaenoic acid.Practical applications: Polyunsaturated fatty acids (PUFA) are highly oxidizable with multiple possibilities of autoxidation and enzyme‐dependent oxygenation. The present review aims at providing a short and comprehensive overview of the biosynthesis of the main oxygenated products derived from 18, 20, and 22 carbon PUFA with their relevant function in the vascular system. The so‐called octadecanoids, eicosanoids, and docosanoids, respectively, are selected among the numerous isomers because of their recognized biological activities.
Controlled field evaluation of water flow rate effects on sampling polar organic compounds using polar organic chemical integrative samplers
Authors: Li Hongxia , Vermeirssen Etiënne L.M. , Helm Paul A. , Metcalfe Chris D. 
Published: July 2010

Abstract
The uptake of polar organic contaminants into polar organic chemical integrative samplers (POCIS) varies with environmental factors, such as water flow rate. To evaluate the influence of water flow rate on the uptake of contaminants into POCIS, flow-controlled field experiments were conducted with POCIS deployed in channel systems through which treated sewage effluent flowed at rates between 2.6 and 37 cm/s. Both pharmaceutical POCIS and pesticide POCIS were exposed to effluent for 21 d and evaluated for uptake of pharmaceuticals and personal care products (PPCPs) and endocrine disrupting substances (EDS). The pesticide POCIS had higher uptake rates for PPCPs and EDS than the pharmaceutical POCIS, but there are some practical advantages to using pharmaceutical POCIS. The uptake of contaminants into POCIS increased with flow rate, but these effects were relatively small (i.e., less than twofold) for most of the test compounds. There was no relationship observed between the hydrophobicity (log octanol/water partition coefficient, log KOW) of model compounds and the effects of flow rate on the uptake kinetics by POCIS. These data indicate that water flow rate has a relatively minor influence on the accumulation of PPCPs and EDS into POCIS. Environ. Toxicol. Chem. 2010;29:2461–2469. © 2010 SETAC
Forecasting volatility: Roles of sampling frequency and forecasting horizon
Authors: Chan Wing Hong , Cheng Xin , Fung Joseph K.W. 
Published: July 2010

AbstractThis study empirically tests how and to what extent the choice of the sampling frequency, the realized volatility (RV) measure, the forecasting horizon and the time‐series model affect the quality of volatility forecasting. Using highly synchronous executable quotes retrieved from an electronic trading platform, the study avoids the influence of various market microstructure factors in measuring RV with high‐frequency intraday data and in inferring implied volatility (IV) from option prices. The study shows that excluding non‐trading‐time volatility produces significant downward bias of RV by as much as 36%. Quality of prediction is significantly affected by the forecasting horizon and RV model, but is largely immune from the choice of sampling frequency. Consistent with prior research, IV outperforms time‐series forecasts; however, the information content of historical volatility critically depends on the choice of RV measure. © 2010 Wiley Periodicals, Inc. Jrl Fut Mark
Current awareness in geriatric psychiatry
Authors:   John Wiley & Sons, Ltd.
Published: July 2010

AbstractIn order to keep subscribers up‐to‐date with the latest developments in their field, John Wiley & Sons are providing a current awareness service in each issue of the journal. The bibliography contains newly published material in the field of geriatric psychiatry. Each bibliography is divided into 9 sections: 1 Reviews; 2 General; 3 Assessment; 4 Epidemiology; 5 Therapy; 6 Care; 7 Dementia; 8 Depression; 9 Psychology. Within each section, articles are listed in alphabetical order with respect to author. If, in the preceding period, no publications are located relevant to any one of these headings, that section will be omitted
Erratum: Synthesis of functional phosphines with ortho‐substituted aryl groups: 2‐RC6H4PH2 and 2‐RC6H4P(SiMe3)2 (R = i‐Pr‐ or t‐Bu)
Authors: Dugal‐Tessier Julien , Kuhn Paul‐Steffan , Dake Gregory R. , Gates Derek P. 
Published: July 2010

AbstractThe synthesis and characterization of 2‐i‐PrC6H4PCl2 (3), 2‐t‐BuC6H4PCl2 (4), 2‐i‐PrC6H4PH2 (5), 2‐t‐BuC6H4PH2 (6), 2‐i‐PrC6H4P(SiMe3)2 (7), and 2‐t‐BuC6H4P(SiMe3)2 (8) are described. © 2010 Wiley Periodicals, Inc. Heteroatom Chem 21:355–360, 2010; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/hc.20619*This is a revised version of the article originally published in Volume 21, Number 4 (Heteroatom Chem 21:265‐270, 2010; DOI 10.1002/hc.20606). Due to an unfortunate publisher's error, the earlier version was posted online and approved for press before the journal's production team had received the authors' proof corrections. The publisher regrets the oversight.
Application of analytical solution for stream depletion due to groundwater pumping in Gapcheon watershed, South Korea
Authors: Kim Gyoo‐Bum 
Published: July 2010

AbstractA number of groundwater wells for agricultural activity, including rice farming and greenhouses, have been developed near streams over the past 20 years in South Korea. The result of a stream depletion calculation using an analytical solution of complimentary error function shows that groundwater pumping at 1949 wells drilled in the Gapcheon watershed can produce stream depletion. This amount is estimated at about 7% of annual baseflow and reaches as high as 18% of monthly baseflow during the maximum agricultural water consumption period in May. Agricultural wells have a larger effect on stream depletion than domestic wells because of their higher pumping rate. Stream depletion from agricultural wells located within 200 m from a stream represents 65% of the total depletion rate. Agricultural water policy for water use at nearby streams should be changed to reduce stream depletion and thereby maintain sustainable water development in South Korea. Copyright © 2010 John Wiley & Sons, Ltd.
Cilengitide inhibits progression of experimental breast cancer bone metastases as imaged noninvasively using VCT, MRI and DCE‐MRI in a longitudinal in vivo study
Authors: Bäuerle Tobias , Komljenovic Dorde , Merz Maximilian , Berger Martin R. , Goodman Simon L. , Semmler Wolfhard 
Published: July 2010

AbstractThe aim of this study was to investigate the effect of inhibiting αvβ3/αvβ5 integrins by cilengitide in experimentally induced breast cancer bone metastases using noninvasive imaging techniques. For this purpose, nude rats bearing established breast cancer bone metastases were treated with cilengitide, a small molecule inhibitor of αvβ3 and αvβ5 integrins (75 mg/kg, five days per week; n = 12 rats) and compared to vehicle‐treated control rats (n = 12). In a longitudinal study, conventional magnetic resonance imaging (MRI) and flat panel volumetric computed tomography were used to assess the volume of the soft tissue tumor and osteolysis, respectively, and dynamic contrast‐enhanced (DCE‐) MRI was performed to determine functional parameters of the tumor vasculature reflecting blood volume and blood vessel permeability. In rats treated with cilengitide, VCT and MRI showed that osteolytic lesions and the respective bone metastatic soft tissue tumors progressed more slowly than in vehicle‐treated controls. DCE‐MRI indicated a decrease in blood volume and an increase in vessel permeability and immunohistology revealed increased numbers of immature vessels in cilengitide‐treated rats compared to vehicle controls. In conclusion, treatment of experimental breast cancer bone metastases with cilengitide resulted in pronounced antiresorptive and antitumor effects, suggesting that αvβ3/αvβ5 inhibition may be a promising therapeutic approach for bone metastases.
Medical radiation exposure and risk of retinoblastoma resulting from new germline RB1 mutation
Authors: Bunin Greta R. , Felice Marc A. , Davidson William , Friedman Debra L. , Shields Carol L. , Maidment Andrew , O'Shea Michael , Nichols Kim E. , Leahey Ann , Dunkel Ira J. , Jubran Rima , Rodriguez‐Galindo Carlos , Schmidt Mary Lou , Weinstein Joanna L. , Goldman Stewart , Abramson David H. , Wilson Matthew W. , Gallie Brenda L. , Chan Helen S.L. , Shapiro Michael , Cnaan Avital , Ganguly Arupa , Meadows Anna T. 
Published: July 2010

AbstractAlthough ionizing radiation induces germline mutations in animals, human studies of radiation‐exposed populations have not detected an effect. We conducted a case‐control study of sporadic bilateral retinoblastoma, which results from a new germline RB1 mutation, to investigate gonadal radiation exposure of parents from medical sources before their child's conception. Parents of 206 cases from nine North American institutions and 269 controls participated; fathers of 184 cases and 223 friend and relative controls and mothers of 204 cases and 260 controls provided information in telephone interviews on their medical radiation exposure. Cases provided DNA for RB1 mutation testing. Of common procedures, lower gastrointestinal (GI) series conferred the highest estimated dose to testes and ovaries. Paternal history of lower GI series was associated with increased risk of retinoblastoma in the child [matched odds ratio (OR) = 3.6, 95% confidence interval (CI) = 1.2–11.2, two‐sided p = 0.02], as was estimated total testicular dose from all procedures combined (OR for highest dose=3.9, 95% CI = 1.2–14.4, p = 0.02). Maternal history of lower GI series was also associated with increased risk (OR = 7.6, 95% CI = 2.8–20.7, p < 0.001) as was the estimated total dose (OR for highest dose = 3.0, 95% CI = 1.4–7.0, p = 0.005). The RB1 mutation spectrum in cases of exposed parents did not differ from that of other cases. Some animal and human data support our findings of an association of gonadal radiation exposure in men and women with new germline RB1 mutation detectable in their children, although bias, confounding, and/or chance may also explain the results.