bluuebunny/crossref_metadata_2025_split huggingface dataset:
Seien wir wählerisch – gehen wir wählen!
Authors: Windbichler Christine 
Published: July 2011

AbstractCountdown zur Onlinewahl der Fachkollegien der DFG: Mit dem „Parlament der Wissenschaft”︁ können sich die Wissenschaftlerinnen und Wissenschaftler in Deutschland selbst die beste Stimme geben – für mehr Qualität und Querdenken in der Forschung und ihrer Förderung
Experimental Investigations into Phosphoric Acid Adsorption on Platinum Catalysts in a High Temperature PEM Fuel Cell
Authors: Kamat A. , Herrmann M. , Ternes D. , Klein O. , Krewer U. , Scholl S. 
Published: July 2011

AbstractDynamic testing of a phosphoric acid‐based high temperature PEM fuel cell shows a peculiar phenomenon. A certain current loss is observed after temperature cycling at constant voltage. This loss is incidentally recovered by applying a cell voltage spike to open circuit voltage. Experimental investigations into temperature, cell voltage, and ageing effects show that this phenomenon might occur due to the orientation of the adsorbed phosphate species on the platinum catalyst surface. Along with some supporting literature and experimental results, a hypothesis is presented in order to explain this occurrence. Phosphoric acid adsorption hysteresis on platinum catalyst due to temperature cycling could cause the temporary cell current loss. Electrode potential‐dependent molecule symmetry of adsorbed phosphate ions could bring about the cell current recovery.
Genomic aberrations in pediatric gliomas and embryonal tumors
Authors: Dahlback Hanne‐Sofie S. , Brandal Petter , Gorunova Ludmila , Widing Eva , Meling Torstein R. , Krossnes Bård K. , Heim Sverre 
Published: June 2011

AbstractThe pathogenesis of pediatric central nervous system tumors is poorly understood. To increase knowledge about the genetic mechanisms underlying these tumors, we performed genome‐wide screening of 17 pediatric gliomas and embryonal tumors combining G‐band karyotyping and array comparative genomic hybridization (aCGH). G‐banding revealed abnormal karyotypes in 56% of tumor samples (9 of 16; one failed in culture), whereas aCGH found copy number aberrations in all 13 tumors examined. Pilocytic astrocytomas (n = 3) showed normal karyotypes or nonrecurrent translocations by karyotyping but the well‐established recurrent gain of 7q34 and 19p13.3 by aCGH. Our series included one anaplastic oligoastrocytoma, a tumor type not previously characterized genomically in children, and one anaplastic neuroepithelial tumor (probably an oligoastrocytoma); both showed loss of chromosome 14 by G‐banding and structural aberrations of 6q and loss of 14q, 17p, and 22q by aCGH. Three of five supratentorial primitive neuroectodermal tumors showed aberrant karyotypes: two were near‐diploid with mainly structural changes and one was near‐triploid with several trisomies. aCGH confirmed these findings and revealed additional recurrent gains of 1q21‐44 and losses of 3p21, 3q26, and 8p23. We describe cytogenetically for the first time a cribriform neuroepithelial tumor, a recently identified variant of atypical teratoid/rhabdoid tumor with a favorable prognosis, which showed loss of 1p33, 4q13.2, 10p12.31, 10q11.22, and 22q by aCGH. This study indicates the existence of distinct cytogenetic patterns in pediatric gliomas and embryonal tumors; however, further studies of these rare tumors using a multimodal approach are required before their true genomic aberration pattern can be finally established. © 2011 Wiley‐Liss, Inc.
Dorsally‐derived oligodendrocytes in the spinal cord contribute to axonal myelination during development and remyelination following focal demyelination
Authors: Zhu Qiang , Whittemore Scott R. , Devries William H. , Zhao Xiaofeng , Kuypers Nicholas J. , Qiu Mengsheng 
Published: June 2011

AbstractIn the developing spinal cord, the majority of oligodendrocytes are derived from the ventral ventricular zone. Several recent studies suggested that a small number of oligodendrocyte precursor cells (OPCs) can also be generated in the dorsal spinal cord. However, it is not clear whether these dorsal oligodendrocyte precursor cells participate in myelination and remyelination. To investigate the fate and potential function of these dorsally‐derived oligodendrocytes (dOLs) in the adult spinal cord, Cre‐lox genetic fate mapping in transgenic mice was employed. We used the Pax3Cre knock‐in mouse to drive Cre expression in the entire dorsal epithelium and the Rosa26‐lacZ or Z/EG reporter line to trace their spatial distribution and population dynamics in the spinal cord. The dorsal OPCs generated from the Pax3‐expressing domains migrate into all regions of spinal cord and subsequently undergo terminal differentiation and axonal myelination. In response to a focal demyelination injury, a large number of newly differentiated oligodendrocytes originated from dOLs, suggesting that dOLs may provide an important source of OPCs for axonal remyelination in multiple sclerosis or spinal cord injury. © 2011 Wiley‐Liss, Inc.
Oncocytic carcinoma of the nasolacrimal duct treated by transnasal endoscopic resection
Authors: Villaret Andrea Bolzoni , Lombardi Davide , Schreiber Alberto , Farina Davide , Nicolai Piero 
Published: June 2011

AbstractBackgroundMalignancies of the nasolacrimal apparatus are rare lesions that usually originate from the lacrimal sac. To the best of our knowledge, this is the first case of a primary oncocytic carcinoma of the nasolacrimal duct reported in the literature.MethodsA 43‐year‐old woman presented with a 3‐month history of right epiphora. At nasal endoscopy, an exophytic lesion occupying the right inferior meatus was visible. Imaging studies showed an expansile lesion involving the nasolacrimal duct and the inferior meatus, but not invading the orbit or adjacent soft tissues. A biopsy was suggestive for an oncocytic lesion.ResultsA radical resection was obtained through an endoscopic extended medial maxillectomy with a definitive diagnosis of oncocytic carcinoma. Forty‐two months after surgery there was no evidence of disease.ConclusionsIn selected malignant lesions of the nasolacrimal duct not involving the adjacent soft tissues or lacrimal sac, an exclusive endoscopic approach can be considered. © 2011 Wiley Periodicals, Inc. Head Neck, 2013
Modelling catchment‐scale water storage dynamics: reconciling dynamic storage with tracer‐inferred passive storage
Authors: Birkel Christian , Soulsby Chris , Tetzlaff Doerthe 
Published: June 2011

AbstractWe investigate the storage–discharge relationships of two nested (3·6 and 30·4 km2) upland catchments using rainfall–runoff models: (1) a nonlinear discharge sensitivity function and (2) a tracer‐constrained process‐based conceptual model. Both approaches explicitly acknowledge that water storage is neither time nor space invariant and this provided insight into the respective scaling relationships. Both modelling approaches consistently demonstrated small seasonal storage fluctuations consistent with the wet, cool Scottish climate: the smaller catchment exhibited a greater average dynamic storage (ca 55 mm) compared to the larger scale (ca 40 mm). However, there are differences in simulated storage quantities and ranges inferred from both models, which can largely be explained by model uncertainties and model assumptions. In contrast to the dynamic (active) storage indicated by the rainfall‐runoff models, input‐output relationships of δ18O in both catchments were used to estimate the passive storage available for mixing and tracer damping in streams. This showed that catchment storage is an order of magnitude greater (ranging from 500 to 900 mm) than the dynamic storage estimated by both models, though again, storage estimates were greater for the smaller catchment. The passive storage inferred for mixing indicates that discussion of dynamic storage revealed by water balance considerations masks a much larger catchment storage which may in turn determine sensitivity to environmental change. Copyright © 2011 John Wiley & Sons, Ltd.
High‐frequency storm event isotope sampling reveals time‐variant transit time distributions and influence of diurnal cycles
Authors: Birkel Christian , Soulsby Chris , Tetzlaff Doerthe , Dunn Sarah , Spezia Luigi 
Published: June 2011

AbstractHigh‐frequency sampling of stable water isotopes in precipitation and stream water during winter and summer storm events was carried out in a 2·3 km2 lowland agricultural catchment. During peak flows of monitored events, the responses of δ2H and δ18O were comparable and inferred the dominance (ca 70%) of ‘old’ pre‐event water. Transit Time Distribution (TTD) inferred by a gamma function were fitted (Nash–Sutcliffe = 0·8) and were also similar for δ2H and δ18O. However, the shape (α) and scaling (β) parameters were markedly different for summer and winter events. Consequently, when antecedent wetness was high, mean transit times were in the order of days; when drier, they increased to months. Moreover, while the responses of δ2H and δ18O exhibited similar gradual recovery to pre‐event conditions during winter hydrograph recessions, they differed dramatically on summer recessions. Time series analysis showed that δ2H isotope content was correlated with the diurnal cycle of air temperature, suggesting an evaporative fractionation pattern which could be reproduced by a temperature‐based first‐order autoregressive model. The heavier δ18O isotope showed no evidence for such diurnal variability. The study highlights the utility of high‐frequency stable isotope sampling to explore the time‐variant nature of TTDs. Furthermore, it shows that the time of sampling in a diurnal cycle may have crucial significance for interpreting stream isotope signatures, particularly δ2H. Copyright © 2011 John Wiley & Sons, Ltd.
Protective effects of salecan against carbon tetrachloride‐induced acute liver injury in mice
Authors: Chen Peng , Wang Zhongqiu , Zeng Liyan , Wang Shiming , Dong Wei , Jia Aiqun , Cai Chun , Zhang Jianfa 
Published: July 2011

ABSTRACTCarbon tetrachloride (CCl4) is a well‐established model for screening hepato‐protective drugs. The aim of the present study was to evaluate the potential protective effects of a novel soluble β‐glucan salecan on acute liver injury induced by CCl4 in mice and to further explore the underlying mechanisms. Mice were given salecan (40 mg kg−1) or phosphate‐buffered saline for 3 days prior to treatment with a single intraperitoneal dose of CCl4 (1 ml kg−1 body weight). Animals were sacrificed at 0, 12, 24, 48, 72 and 96 h post‐injection of CCl4. Serum liver enzyme levels, histology, lipid peroxidation, glutathione (GSH) content, expression of antioxidant enzymes and hepatocyte proliferation were subsequently evaluated. The serum levels of hepatic enzyme markers were markedly reduced in the salecan pretreatment group compared with the control group. Histopathological examination of the livers revealed that hepatocellular degeneration and necrosis were significantly attenuated at an early stage during CCl4 intoxication and liver recovery was markedly accelerated at a later stage in salecan pre‐administered mice. Furthermore, salecan administration remarkably alleviated lipid peroxidation and restored GSH depletion. Meanwhile, the expression of antioxidant genes was significantly elevated in the salecan‐treated group. Interestingly, the administration of salecan remarkably enhanced hepatocyte proliferation in the recovery phase after CCl4 injection. Taken together, these results demonstrated that salecan exhibits a protective action on acute hepatic injury induced by CCl4 through attenuating oxidative stress and accelerating hepatocyte regeneration. Copyright © 2011 John Wiley & Sons, Ltd.
Founder's award to antonios G. Mikos, Ph.D., 2011 society for biomaterials annual meeting and exposition, Orlando, Florida, April 13–16, 2011
Authors: Kretlow James D. , Mikos Antonios G. 
Published: June 2011

AbstractFor biomaterials scientists focusing on tissue engineering applications, the gold standard material is healthy, autologous tissue. Ideal material properties and construct design parameters are thus both obvious and often times unachievable; additional considerations such as construct delivery and the underlying pathology necessitating new tissue yield additional design challenges with solutions that are not evident in nature. For the past nearly two decades, our laboratory and collaborators have aimed to develop both new biomaterials and a better understanding of the complex interplay between material and host tissue to facilitate bone and cartilage regeneration. Various approaches have ranged from mimicking native tissue material properties and architecture to developing systems for bioactive molecule delivery as soluble factors or bound directly to the biomaterial substrate. Such technologies have allowed others and us to design synthetic biomaterials incorporating increasing levels of complexity found in native tissues with promising advances made toward translational success. Recent work focuses on translation of these technologies in specific clinical situations through the use of adjunctive biomaterials designed to address existing pathologies or guide host‐material integration. © 2011 Wiley Periodicals, Inc. J Biomed Mater Res Part A:, 2011.
Isocyanate‐functional adhesives for biomedical applications. Biocompatibility and feasibility study for vascular closure applications
Authors: Hadba Ahmad R. , Belcheva Nadya , Jones Fatima , Abuzaina Ferass , Calabrese Allison , Kapiamba Mbiya , Skalla Walter , Taylor Jack L. , Rodeheaver George , Kennedy John 
Published: June 2011

AbstractBiodegradable isocyanate‐functional adhesives based on poly(ethylene glycol)–adipic acid esters were synthesized, characterized, and evaluated in vitro and in vivo. Two types of formulations, P2TT and P2MT, were developed by functionalization with 2,4‐tolylene diisocyanate (TDI) or 4,4′‐methylene‐bis(phenyl isocyanate) (MDI), respectively, and branching with 1,1,1‐trimethylolpropane (TMP). The biocompatibility of the synthesized adhesive formulations was evaluated as per ISO 10993. Cytotoxicity, systemic toxicity, pyrogenicity, genotoxicity (reverse mutation of Salmonella typhimurium and Escherichia coli), hemolysis, intracutaneous reactivity, and delayed‐type hypersensitivity were evaluated. All formulations met the requirements of the conducted standard tests. The biological behavior and ability of the adhesive formulations to close an arteriotomy and withstand arterial pressure following partial approximation with a single suture were evaluated in a rat abdominal aorta model. Animals were evaluated at 1, 2, 3, and 4 weeks after surgery. Macroscopic and histopathologic evaluation of explanted arteries suggested that the P2TT formulation had better in vivo performance than the P2MT formulation. Additionally, the P2TT formulation resulted in less tissue reaction than P2MT formulation. To our knowledge, this is the first study demonstrating the potential of this new class of isocyanate‐functional degradable adhesives for vascular applications. © 2011 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2011.
Hypophosphatasia: Nonlethal disease despite skeletal presentation in utero (17 new cases and literature review)
Authors: Wenkert Deborah , McAlister William H , Coburn Stephen P , Zerega Janice A , Ryan Lawrence M , Ericson Karen L , Hersh Joseph H , Mumm Steven , Whyte Michael P 
Published: June 2011

Abstract
Hypophosphatasia (HPP) is caused by deactivating mutation(s) within the gene that encodes the tissue-nonspecific isoenzyme of alkaline phosphatase (TNSALP). Patients manifest rickets or osteomalacia and dental disease ranging from absence of skeletal mineralization in utero to only loss of adult dentition. Until recently, HPP skeletal disease in utero was thought to always predict a lethal outcome. However, several reports beginning in 1999 emphasized a benign prenatal form of HPP (BP-HPP) where skeletal disease detected in utero had a mild postnatal course. Here we describe prenatal and postnatal findings of 17 additional BP-HPP patients among our 178 pediatric HPP patients. Their findings are compared with those of their siblings with HPP, carrier parents, and others with identical TNSALP mutations. New information concerning 7 previously published BP-HPP patients accompanies a review of the HPP literature. Among our 17 BP-HPP patients, prenatal ultrasound showed normal chest or abdominal circumferences where recorded. Sometimes, poor skeletal mineralization, fetal crowding, and third-trimester improvement were observed. Postnatally, extremity bowing further improved (13 patients). BP-HPP severity postnatally spanned the “infantile” to “odonto” HPP phenotypes, resembling our patients who harbored identical TNSALP mutation(s). Eight had autosomal dominant (AD) and 9 had autosomal recessive (AR) BP-HPP. Fourteen of our 15 mothers were HPP carriers or affected. Of the 41 cumulative BP-HPP patients (24 literature cases meriting a BP-HPP diagnosis since 1996 plus our 17 patients), 63% had AR BP-HPP. Maternally transmitted HPP involved 11 of the 13 total AD BP-HPP probands (p = 0.01), supporting a maternal in utero effect on the baby. Fetal crowding, normal fetal mineralization and chest size, and TNSALP heterozygosity seem to identify BP-HPP. However, bowed fetal long bones with AR HPP, specific TNSALP mutations, or poor skeletal mineralization before the third trimester do not reliably diagnose HPP lethality. © 2011 American Society for Bone and Mineral Research
DockoMatic: Automated peptide analog creation for high throughput virtual screening
Authors: Jacob Reed B. , Bullock Casey W. , Andersen Tim , McDougal Owen M. 
Published: June 2011

AbstractThe purpose of this manuscript is threefold: (1) to describe an update to DockoMatic that allows the user to generate cyclic peptide analog structure files based on protein database (pdb) files, (2) to test the accuracy of the peptide analog structure generation utility, and (3) to evaluate the high throughput capacity of DockoMatic. The DockoMatic graphical user interface interfaces with the software program Treepack to create user defined peptide analogs. To validate this approach, DockoMatic produced cyclic peptide analogs were tested for three‐dimensional structure consistency and binding affinity against four experimentally determined peptide structure files available in the Research Collaboratory for Structural Bioinformatics database. The peptides used to evaluate this new functionality were alpha‐conotoxins ImI, PnIA, and their published analogs. Peptide analogs were generated by DockoMatic and tested for their ability to bind to X‐ray crystal structure models of the acetylcholine binding protein originating from Aplysia californica. The results, consisting of more than 300 simulations, demonstrate that DockoMatic predicts the binding energy of peptide structures to within 3.5 kcal mol−1, and the orientation of bound ligand compares to within 1.8 Å root mean square deviation for ligand structures as compared to experimental data. Evaluation of high throughput virtual screening capacity demonstrated that Dockomatic can collect, evaluate, and summarize the output of 10,000 AutoDock jobs in less than 2 hours of computational time, while 100,000 jobs requires approximately 15 hours and 1,000,000 jobs is estimated to take up to a week. © 2011 Wiley Periodicals, Inc. J Comput Chem, 2011
Speaking freely: my experiences in individual psychotherapies, group therapies, and growth groups
Authors: Curtis Rebecca Coleman 
Published: June 2011

AbstractThis article traces the author's experiences in sensitivity, Tavistock, and psychotherapy groups, an experience in individual psychotherapy, and two experiences in psychoanalysis. Group work was very helpful in learning how the author came across to others in general and in improving the author's ways of being helpful to others. Although the experience was valuable, difficulties emerged in the first psychoanalysis, largely because of the psychoanalyst's belief that psychoanalysis was the best form of treatment for everyone. Desiring a variety of approaches, the author undertook a second analysis with more of an integrative and intuitive therapist, which worked better for her. Lasting lessons are shared from this series of personal therapy experiences. © 2011 Wiley Periodicals, Inc. J Clin Psychol 67:1–12, 2011.
Behavior of 3(2‐pyridinylmethylene)‐5‐aryl‐2(3H)‐furanones and 3(3‐pyridinylmethylene)‐5‐aryl‐2(3H)‐furanones as alkylating agents: A comparative study
Authors: Abou Elmagd Wael S. I. 
Published: June 2011

Abstract3(2‐pyridinylmethylene)‐5‐aryl‐2(3H)‐furanones and 3(3‐pyridinylmethylene)‐5‐aryl‐2(3H)‐furanones were prepared as a mixture of (E) and (Z) stereoisomers by condensing pyridine‐2‐carboxaldehyde and pyridine‐3‐carboxaldehyde with 3‐aroylpropionic acids. The reaction of the furanones 6 and 7 with anhydrous aluminium chloride in benzene led to the formation of 4,4‐diaryl‐1‐(2‐pyridinyl)but‐1,3‐diene (8) and 4,4‐diaryl‐1‐(3‐pyridinyl)but‐1,3‐diene (9) as mixtures of geometrical (E,E‐ and E,Z‐) stereoisomers via an intermolecular alkylation mode. When the reaction was carried out in tetrachloroethane as a solvent, the reaction of 6 gave 5‐arylquinoline‐7‐carboxylic acid via intramolecular alkylation mode. This may be considered as a novel method for the synthesis of quinoline derivatives. J. Heterocyclic Chem., (2011).
On the evolution of arterial vascular patterns of tetrapods
Authors: Farmer C.G. 
Published: June 2011

AbstractThe factors that explain the diverse arrangement of the major arteries of tetrapods are not known. Here, I aim to illuminate some of the underpinnings of these patterns. I review the variation in the sauropsid left, right, and dorsal aortae regarding the origin of the gastrointestinal blood vessels and the relative diameters of left and right aortae where they join together to form the dorsal aorta. I focus on these features because the quality of blood that flows through these aortae can vary depending on the state of cardiac shunting and the size of the vessel can provide insight into the quantity of blood borne by the vessels. I then place the information in a phyletic, historical, and ecological context. The plesiomorphic pattern is for the gastrointestinal vessels to arise as segmental arteries from the dorsal aorta, which is formed from the confluence of left and right aortae with similar diameters. The pattern is well conserved with only two major variations. First, in several clades of reptiles (testudines, crocodilians, lizards of the generaVaranusandHydrosaurus) a substantial portion of the gastrointestinal arteries arises from the left aorta, leaving the diameter of the left aorta smaller than the right at their confluence. I hypothesize that this vascular arrangement facilitates growth by allowing more alkaline blood to flow to the somatic (body wall) and appendicular circulations, which may promote bone deposition and inhibit resorption, whereas hypercapnic, acidic blood flows to the digestive viscera, which may provide CO2as a substrate for the synthesis of gastric acid, bicarbonate, fatty acids, glutamine, purine rings, as well as glucose from lactate. Second, in some snakes and lizards with snake‐like body forms, such as Amphisbaenidae, the diameters of left and right aortae are asymmetrical at their confluence with the left aorta exceeding the right, but in members of the amphibian order Gymnophiona the right generally exceeds the left. This condition is associated with asymmetrical development of the lungs. J. Morphol. 2011. © 2011 Wiley‐Liss, Inc.