bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Potential Mechanism of Eriodictyol in Treating Alzheimer's Disease: A Study on
Computer-assisted Investigational Strategies
Authors: Du Dan , Qin Chunmeng , Sun Mei , Lv Feng , Li Wenjun , Liu Songqing 
Published: June 2024

Background:
At present, drug development for treating Alzheimer’s disease (AD) is still highly
challenging. Eriodictyol (ERD) has shown great potential in treating AD, but its molecular mechanism is unknown.

Objective:
We aimed to explore the potential targets and mechanisms of ERD in the treatment of AD through
network pharmacology, molecular docking, and molecular dynamics simulations.

Methods:
ERD-related targets were predicted based on the CTD, SEA, PharmMapper, Swiss TargetPrediction,
and ETCM databases, and AD-related targets were predicted through the TTD, OMIM, DrugBank,
GeneCards, Disgenet, and PharmGKB databases. Protein-protein interaction, Gene Ontology (GO), and Kyoto
Encyclopedia of Genes and Genomics analyses (KEGG) were used to analyse the potential targets and key
pathways of the anti-AD effect of ERD. Subsequently, potential DEGs affected by AD were analysed using
the AlzData database, and their relationships with ERD were evaluated through molecular docking and molecular
dynamics simulations.

Results:
A total of 198 ERD-related targets, 3716 AD-related targets, and 122 intersecting targets were identified.
GO annotation analysis revealed 1497 biological processes, 78 cellular components, and 132 molecular
functions of 15 core targets. KEGG enrichment analysis identified 168 signalling pathways. We ultimately
identified 9 DEGs associated with AD through analysis of the AlzData data. Molecular docking results
showed good affinity between the selected targets and ERD, with PTGS2, HSP90AA1, and BCL2. The interactions
were confirmed by molecular dynamics simulations.

Conclusion:
ERD exerts anti-AD effects through multiple targets, pathways, and levels, providing a theoretical
foundation and valuable reference for the development of ERD as a natural anti-AD drug.
At the Speed of Light: Recent Advances on Photocatalyzed Generation and
Applications of Iminyl Radicals Promoted by Visible-light
Authors: Valle-Sánchez Mario , López-Saladino Osvaldo F. , González-Rivas Nelly , Estévez-Martínez Yoxkin , Frontana-Uribe Bernardo A. , Cuevas-Yañez Erick 
Published: June 2024

:
Nitrogen-positioned radicals are chemical entities that have a lengthier history
than carbon ones and their high reactivity makes them invaluable. But, despite its power,
much of its chemistry is still uncharted. Currently, developed methodologies to access
nitrogen-positioned radicals, such as transition metal catalysis or visible-light photoredox
methods through a single-electron transfer process, avoiding the use of harmful or toxic
reagents, excess raw materials, solvents as well as pre-functionalization steps or extensive
synthetic routes are in continuous progress. This revision aims to depict the recent
advances in the field of iminyl-radicals’ syntheses, a special class of radicals placed on
nitrogen, catalyzed by transition metals or photoredox techniques for the construction of
C-N bonds and their synthetic applications. This work serves as a comprehensive guide for
the scope of synthetic applications that this kind of radicals could have.
In Silico ADME And Molecular Docking Studies of New Thiazolyl-bipyrazole,
Pyrazolopyridine and Pyrano[2,3-d]pyrazolopyridine Derivatives as Antibacterial Agents
Authors: Metwally Heba M. , Abdel-Latif Ehab , El-Rayyes Ali 
Published: June 2024

:
In this study, a series of novel pyrazole-based compounds were synthesized starting
from the precursor ethyl 3-(4-amino-1-phenyl-3-((4-sulfamoylphenyl)carbamoyl)-1Hpyrazol-
5-yl)-3-oxopropanoate (2). Various synthetic routes were used to obtain pyrazolylpyrazolone
3, tricyclic dipyrazolopyridine 4a-c, thiazolyl-bipyrazoles 5 & 6, pyrazolo[4,3-
b]pyridines 7 & 9, and tricyclic pyranopyrazolopyridine 10a–c. These compounds were
screened for their antibacterial activity against four bacterial strains. The promising candidates
4a, 4b, 4c, 7, 9, and 10c exhibited minimum inhibitory concentrations ranging from
0.98 to 31.25 μg/mL. The in silico ADME properties for the active compounds exhibited
similar physiochemical properties, with compound 9 demonstrating the best likeness and no
inhibition effect on the popular drug metabolism enzyme CYP. Molecular docking simulations
highlighted compounds 9 and 10c as potent antibacterial agents via DNA-gyrase inhibition
1,4-Diazabicyclo[2.2.2]octane (DABCO) in Organic Synthesis and Catalysis: A
Quinquennial Report (2019-to Date)
Authors: Varala Ravi , Seema Vittal , Alam Mohammed Mujahid , Amanullah Mohammed , Prasad Beda Durga 
Published: June 2024

:
DABCO is one of the more effective basic organocatalysts/reagents that can be
used for a range of organic transformations, including C-H functionalization, formation of
hetero-hetero bonds, rearrangements, the synthesis of heterocyclic compounds, cyclizations
and annulations, other miscellaneous reactions. This quinquennial review aims to critically
and perceptively address noteworthy contributions of non chiral catalyst DABCO for regular
organic transformations from 2019 onward. The key areas of attention were the advantages
and limits of the approach, in addition to the mechanistic pathway, which is required
for a specific organic transformation to be performed effectively.
Air Pollution in the United States and Misstatements in Financial Reporting
Authors: Chen Jade Huayu , Michas Paul N. , Russomanno Dan , Zhuang Wenzi 
Published: June 2024

SUMMARY
We argue air pollution can jointly impede the quality of work performed by a client’s financial reporting personnel and its auditor. We exploit PM2.5 data from the Environmental Protection Agency and find a positive association between air pollution and misstatements in annual financial reports. Moreover, we find this association using a subsample where auditors must travel a significant distance to their client’s headquarters and accordingly, are more likely to be exposed to a change in air pollution. Finally, our main finding is more salient when both a client’s reporting personnel and its auditor are likely to be present on site, as well as in more complex engagements where the physical and cognitive demands placed on a client’s reporting personnel and its auditor are likely higher. We interpret this evidence as air pollution impeding the quality of work performed by a client’s reporting personnel, its auditor, or both.
Data Availability: All data used in the study are publicly available.
JEL Classifications: I10; M41; M42; Q53.
The Effects of IT Management Certification Type and Corporate Social Responsibility Performance on Investors’ Responses to Cybersecurity Breaches
Authors: Tang Fengchun , Yang Ling 
Published: June 2024

ABSTRACT
We investigate the joint effects of IT management certification type (for example, International Organization for Standardization (ISO) 27001 certification, the certification of a company’s Information Security Management System against the ISO 27001 standard, the leading international standard focused on information security) and CSR performance on investors’ responses to cybersecurity breaches. We find that the ISO 27001 certificate issued by an independent certification body serves as a proactive remedial strategy for reputation management and attenuates investors’ negative reactions following data breaches. However, the connection between the certification body that issues the certificate and the financial audit firm of the audited company may impair the effectiveness of the certificate serving as a remedial strategy for cybersecurity breaches. Similarly, superior CSR performance provides insurance-like protection and spillovers to reduce investors’ negative responses to cybersecurity breaches. We also provide some evidence suggesting that IT management certification type and CSR performance are likely substitutive mechanisms.
Möjligheter att genom kroppsligt lärande beröra studenter i digitala rum
Authors: Järnerot Anna 
Published: June 2024

The article presents and discusses the experiences of the author and some colleagues when they tested the use of digital roleplay in several teaching groups. This was done in the context of a fourth-year pedagogy course in Norwegian teacher education for primary and lower secondary school. The course’s syllabus concerns school as an organisation, and as such, collaboration within the school and with external people. The project was a form of action research or self-study of a limited part of the teaching that semester. The research focus was: “What possibilities are there in using digital roleplay to create embodied, transformative and/or enactive learning?” The author shares how the digital roleplay was organised, what the student teachers and the teacher educators thought about the activity and the learning outcome. The theoretical lenses used come from transformative, enactive and embodied learning. The article also examines how drama/roleplay can be used as a mediating tool to promote learning through an interplay of the body, mind, and surroundings, hopefully affecting the whole person and possibly changing the individual.
The results indicate that digital roleplay is a viable tool and that the students experienced embodied responses, which in turn influenced their cognition, in this case their understanding of the drama-topic (homework) and drama-focus (how people can use various techniques to dominate situations and gain power in ordinary life). Even so, the author concludes that it takes more than one roleplay session to change a person’s identity.
Formulation of Natural Food Coloring Based on Cempasúchil (TAGETES ERECTA) in Traditional Mexican Day of The Dead Bread
Authors: Paredes Yesbek Rocío Morales , Carrillo Teresa Gladys Cerón , Rojas Mariana Eliosa , Gutiérrez Karla Paola Rodríguez 
Published: June 2024

Objective: To develop a natural colorant from the marigold flower through 7 extraction methods, to substitute the use of artificial colorants in the elaboration of traditional Mexican Day of the Dead bread.

Theoretical framework: Flowers have been used as food, decoration, medicine and pigment due to their attributes; in Mexico there is the marigold flower known for its use in the Day of the Dead celebration. Several studies have shown negative consequences of the consumption of artificial foods on human health, an example is the artificial colorants that can be substituted by the natural ones contained in flowers.

Methods: In this descriptive, cross-sectional and mixed article, 7 methods of extraction of dye from cempasúchil flowers for use in pan de muerto were developed by students and researchers of the Benemérita Universidad Autónoma de Puebla.

Results and discussion: The tones obtained in the bread were green (undesirable for consumption), derived from the extraction method used, being also important factors the use of inputs of animal or vegetable origin and the preparation techniques.

Practical implications: linked to the stabilization and fixation of the color in the bread due to the fact that the cempasúchil enzymes reacted when in contact with the pH of the dough, friction, oxygen and temperature, resulting in the green color.

Originality: The present study contributes to promote the creation of natural colorant alternatives based on edible flowers through natural methods to obtain them.
The National Curriculum and Its Adaptation to Primary Curriculum Development For Inclusive Students with Visual Impairments: Perspectives of Teachers
Authors: Nguyen Thang The , Tran Thu-Giang , Mai Thi Phuong , Nguyen Thi Hang , Nguyen Thi Bac , Nguyen Thi Anh Duong 
Published: June 2024

Objective: The objective of this study is to investigate the perspectives of teachers who have been teaching students with special needs, with the aim of how to develop a suitable curriculum for students with visual impairments. Theoretical Framework: In this topic, the main concepts and theories that underpin the research presented regarding the curriculum of visual impairments stand out, providing a solid basis for understanding the context of the investigation. Method: Using a teacher's questionnaire focused on adapting the national curriculum to a curriculum for inclusive students with visual impairments in terms of curriculum development, contents of the curriculum, and influencing factors. Results and Discussion: The findings show that it is possible that the adaptation will be successful if all necessary conditions are well prepared and carefully considered by managing the influencing factors with full consideration. Special education is a sector that has been interested by many stakeholders who have profoundly taken care of these students with special needs, making them and other students with manifold benefits, but it is invariably difficult to develop a suitable curriculum to meet the varied demands of these learners Research Implications: The practical and theoretical implications of this research are discussed, providing insights into how the results can be applied or influence practices in the field of developing a curriculum for students with visual impairments. There is a need for further studies on the perspectives of these special students and their parents. Originality/Value: This study contributes to the literature by providing perspectives on teachers teaching students with visual impairments and adapting the national curriculum to a suitable curriculum that meets the demands of the students with visual impairments.
Exploring Innovation Sustainability in the Development Historical City Batik Motifs and People's Purchasing Power
Authors: Indarti  
Published: June 2024

Objective: This study aims to explore the relationship between the development of Surabaya's distinctive historical batik motifs and people's purchasing power as a basis for sustainable innovation transformation. Theoretical Framework: The research explores the relationship between the development of Historical City Batik Motifs, People's Purchasing Power, and Sustainability Innovation, utilizing concepts such as stakeholder analysis, business model canvas, and life cycle assessment to assess the impact of these variables on sustainable innovation. Method: The research sample was conducted on batik craftsmen, batik designers, and the general public as many as 90 respondents. This study used mixed methods. Qualitative research is used to determine the phenomena that occur in the community in the form of the development of historical city batik motifs. While quantitative studies to test innovations can continue based on which variables. Results and Discussion: The results showed that the development of batik motifs in this study illustrates themes such as the theme of Red Bridge, Jalesveva Jayamahe, Heroes Monument and Pointed Bamboo, Monkasel, Remo Dance, Distance and Butterfly, and Jalan Tunjungan. The historical city batik motifs development variable has a very small or insignificant effect on sustainability innovation, while people's purchasing power has a large effect on the Sustainability Innovation variable. Research Implications: This research makes a positive contribution in promoting the richness of local culture and creating added value for the batik industry in Surabaya. The implications of this research can be an inspiration for local batik craftsmen to develop new motifs that depict the identity of a particular city, as well as show indicators that need to be improved to create sustainable innovation. Originality/Value: This study contributes to producing new designs inspired by the history and uniqueness of the city and provides an impact on what indicators must be improved to maintain Sustainability Innovation.
Exploratory Educational Initiatives Enhancing Primary School Teachers' Ability to Guide and Assist Students in Learning Activities
Authors: Le Duyen Thi , Le Son Quang , Bui Dieu Thi Thanh 
Published: June 2024

Purpose: This study investigates measures to develop primary school teachers' capacity to advise and support students in educational activities.

Methods: The research involved expert opinion surveys, pedagogical experiments, and practical case evaluations with 38 teachers from Da Nang City, Vietnam. Expert opinions, solicited from education managers and educational psychology lecturers, supported the necessity and feasibility of proposed measures.

Results: Pedagogical experiments demonstrated significant post-training improvements in teachers' identification of students' difficulties and advisory skills. Practical case evaluations showcased the model's effectiveness in addressing students' challenges. Quantitative analysis revealed unanimous agreement on the appropriateness and feasibility of proposed measures, while qualitative analysis highlighted teachers' enhanced abilities in creating supportive learning environments.

Implications of research: The study underscores the importance of proactive strategies in enhancing teacher-student engagement and support mechanisms, with implications for educational practice and policy. By triangulating data from multiple sources, the research provides comprehensive insights into the impact and implications of teacher support interventions.

Originality: These findings offer valuable guidance for educators, policymakers, and researchers seeking to promote positive educational outcomes in primary school settings.
Mapping Organizational Culture Trends in Hospital Management: A Bibliometric Analysis and Future Research Directions
Authors: Mukhlis Ahmad , Listiowati Ekorini 
Published: June 2024

Introduction: A hospital is a very complex organization that provides health services through health maintenance approaches (promotive, preventive, curative, and rehabilitative), which are implemented thoroughly by applicable laws and regulations.

Purpose: This study aims to determine the development of research with the theme of Organizational Culture in Hospital Management in the range of 2013 to 2023 through the help of the Vosviewers application in visualizing data.

Design/methodology/approach: The method used in this study is qualitative research with a literature study approach. As for the data found, 266 documents were obtained and analyzed. These datasets are converted to CSV format, BibTeX, and RIS format and imported into bibliophilia for bibliometrics and analysis.

Findings: The results showed that 2015 was the year with the highest number of publications on the topic of Organizational Culture in Hospital Management. The United States is the country that influences scientific publications the most. Bradley, E.H., along with other authors, is the most prolific author with four documents in the field of Organizational Culture and Hospital Management. The focus of this research is on how organizational culture plays a role in creating a safe, supportive, and efficient work environment that impacts patients. There is also great potential for further research in areas such as health care policy, nursing, quality management, personal management, and organizational innovation, which still has the potential to be explored more deeply in the context of Organisational Culture in Hospital Management.

Originality/Value: Ongoing research trends reflect the increasing efficiency in strengthening practices of implementing organizational culture in hospital management practices, which is expected to contribute to advances in the management of responsive and managed health systems.
La fabrication du « peuple » dans le discours de campagne présidentielle sur Twitter d’Éric Zemmour
Authors: Gattiglia Nora 
Published: June 2024

Malgré la centralité de la notion de « peuple » dans les discours populistes, souvent son référent reste vague et indéterminé. Dans cet article, les tweets de campagne présidentielle d’Éric Zemmour contenant le mot « peuple » seront étudiés dans le cadre de l’analyse du discours de tradition française. Un sujet populaire aux traits précis émerge de l’analyse des stratégies de catégorisation et des stratégies rhétoriques et argumentatives, notamment le recours fait à l’implicite et des paralogismes.
Le « populisme » au Québec : approches lexicographiques et discursives
Authors: MOLINARI Chiara 
Published: June 2024

Dans cette contribution nous nous proposons d’explorer les différentes stratégies discursives mises en œuvre par les journalistes afin de définir le populisme au Québec. Phénomène connu depuis longtemps, le populisme a fait l’objet de nombreuses recherches et débats. Mais qu’en est-il au Québec ? Après avoir présenté rapidement les contextes socio-historique, socio-politique et socio-culturel québécois, nous allons suivre d’abord la façon dont le concept évolue sur le plan lexicographique et ensuite sur le plan discursif. De façon plus spécifique, à partir d’un corpus tiré du quotidien québécois Le Devoir, nous nous proposons de faire ressortir les modalités discursives à travers lesquelles les journalistes co-construisent une/des représentations du populisme au Québec.
Psychoactive substances: consumption among workers from the mobile urgency care system
Authors: Fernandes Márcia Astrês , Mesquita Mayrla Karen Rodrigues , Moura Danielle Machado Oliveira de , Paula Janaina dos Santos Francisco de , Silva Angela dos Santos , Carvalho Rosa Jordana , Pillon Sandra Cristina 
Published: June 2024

Objective: To evaluate the consumption of psychoactive substances by health workers from the Mobile Urgency Care Service. Methods: A cross-sectional study conducted at a Public Health service located in a city in Piauí. Data collection took place from January to March 2019 by applying the following instruments in personal interviews: one with occupational, sociodemographic and economic characteristics; and the Alcohol, Smoking and Substance Involvement Screening Test (ASSIST). The data were organized and processed in the Statistical Package for the Social Sciences (SPSS) software (version 19.0). Results: Of the 68 health professionals, 42 were male, with a mean age of 49.8 years old. Among them, 44 were married and 48 were Catholics. The most prevalent professional category was Nursing Technician, accounting for 46.2%. Among these workers, alcohol was the most used psychoactive substance (54 professionals), followed by tobacco consumption (25) and hypnotics (8). It is noted that tobacco was the substance most commonly used on a daily basis. Conclusion: Consumption of psychoactive substances among health professionals was evident and can be related to the pressure resulting from these positions. Attention is drawn to the importance of expanding this debate and addressing health workers' mental health.
Software programs developed to operationalize the nursing process in health services: scoping review
Authors: Nascimento Rafaela Cavalcanti de Albuquerque , Aquino Bárbara Coeli Oliveira Silva , Oliveira Dayvison Nascimento de , Feijão Alexsandra Rodrigues 
Published: June 2024

Objective: To map the software programs developed to operationalize the nursing process in patient care in health services. Methods: This is a scoping review developed within the recommendations of the Joanna Briggs Institute and PRISMA Extension for Scoping Reviews. A search was carried out in seven databases, a library, eight databases and an academic search engine with no time limit. Results: 19,645 studies were found, of them were included 35. 51% addressed Nursing Theory and 20% of the studies covered the entire nursing process. In addition, 82% used the Nursing Process in a fragmented way. The highlighted target audience for which the software programs were developed: adults (26; 74.2%), and the hospital service (33; 94%). Conclusion: It was understood through this study that Brazilian nursing seeks systems that can provide subsidies regarding the application of knowledge in nursing care and process.