bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluating intra‐fractional tumor motion in lung stereotactic radiotherapy with deep inspiration breath‐hold
Authors: Fu Weihua , Zhang Yongqian , Mehta Kiran , Chen Alex , Musunuru Hima Bindu , Pucci Pietro , Kubis Jason , Huq M. Saiful 
Published: May 2024

AbstractPurposeTo evaluate the intra‐fractional tumor motion in lung stereotactic body radiotherapy (SBRT) with deep inspiration breath‐hold (DIBH), and to investigate the adequacy of the current planning target volume (PTV) margins.MethodsTwenty‐eight lung SBRT patients with DIBH were selected in this study. Among the lesions, twenty‐three were at right or left lower lobe, two at right middle lobe, and three at right or left upper lobe. Post‐treatment gated cone‐beam computed tomography (CBCT) was acquired to quantify the intra‐fractional tumor shift at each treatment. These obtained shifts were then used to calculate the required PTV margin, which was compared with the current applied margin of 5 mm margin in anterior‐posterior (AP) and right‐left (RL) directions and 8 mm in superior‐inferior (SI) direction. The beam delivery time was prolonged with DIBH. The actual beam delivery time with DIBH (Tbeam_DIBH) was compared with the beam delivery time without DIBH (Tbeam_wo_DIBH) for the corresponding SBRT plan.ResultsA total of 113 treatments were analyzed. At six treatments (5.3%), the shifts exceeded the tolerance defined by the current PTV margin. The average shifts were 0.0 ± 1.9 mm, 0.1±1.5 mm, and ‐0.5 ± 3.7 mm in AP, RL, and SI directions, respectively. The required PTV margins were determined to be 4.5, 3.9, and 7.4 mm in AP, RL, and SI directions, respectively. The average Tbeam_wo_DIBH and Tbeam_DIBH were 2.4 ± 0.4 min and 3.6 ± 1.5 min, respectively. The average treatment slot for lung SBRT with DIBH was 25.3 ± 7.9 min.ConclusionIntra‐fractional tumor motion is the predominant source of treatment uncertainties in CBCT‐guided lung SBRT with DIBH. The required PTV margin should be determined based on data specific to each institute, considering different techniques and populations. Our data indicate that our current applied PTV margin is adequate, and it is possible to reduce further in the RL direction. The time increase of Tbeam_DIBH, relative to the treatment slot, is not clinically significant.
Combating false information in military situations: Striking the right balance between continued influence effect and overcorrection
Authors: Laurent Victor , Kosinski Thierry , Rusinek Stéphane 
Published: May 2024

AbstractFalse information (FI) is a critical issue for the military, and correction is a common strategy to counteract its influence. However, literature questions the potential of correction to fully restore optimal reasoning. Some studies suggest an overcorrection effect, aligning attitudes excessively with the correction, while others highlight the continued influence effect (CIE), where attitudes persist in alignment with FI. This research aimed to examine the effect of an FI correction within military scenarios. A total of 61 participants read four military scenarios designed to simulate decision‐making, followed by an assessment of their inferential reasoning. Two of the scenarios presented FI which was later retracted, and the two remaining scenarios did not. The results did not reveal any evidence of the CIE, but an overcorrection effect emerged in decision‐making. The study underscores an underestimated threat in countering misinformation. The theoretical and practical implications are discussed.
Green, Biodegradable, and Flexible Resistive Heaters‐Based Upon a Novel Laser‐Induced Graphene Manufacturing Process
Authors: Morais Rogério Miranda , Vieira Douglas Henrique , Ozório Maiza da Silva , Nogueira Gabriel Leonardo , Rollo Andrew , Kettle Jeff , Alves Neri 
Published: May 2024

AbstractLaser induced graphene (LIG), prepared directly with an in situ synthesis method onto Kraft Paper substrates, is proposed for the manufacture of biodegradable electronic devices. The investigation explores the influence of laser power and scanning speed on the properties of LIG conductive tracks and a sheet resistance of up to 0.25 kΩ sq−1. Raman spectroscopy and microscopy is used to analyse the interfacial properties, in particular the transition of cellulose fibers to carbonized graphene flakes through photothermal pyrolysis, leading to the formation of coral‐like structures. To demonstrate the applicability of the approach, flexible resistive heaters have been manufactured and tests show rapid heating with a homogeneous distribution and a maximum temperature of 145.5 °C. Additionally, an electro‐thermal conversion efficiency (hr+c) of 17.05 mW (°C cm2)−1 is achieved. Finally, a comparative Life Cycle Assessment with FR‐4 based electronics has been undertaken and the environmental impacts are calculated. The impact assessment shows a two magnitude lower impact on the environment for most categories, which suggests the approach is beneficial for the environment at a global production level. The results show that the photothermal pyrolysis of Kraft paper using a laser diode allows for low‐impact devices flexible and green electronics products.
USP25 Elevates SHLD2‐Mediated DNA Double‐Strand Break Repair and Regulates Chemoresponse in Cancer
Authors: Li Yunhui , Li Lei , Wang Xinshu , Zhao Fei , Yang Yuntong , Zhou Yujuan , Zhang Jiyuan , Wang Li , Jiang Zeshan , Zhang Yuanyuan , Chen Yuping , Wu Chenming , Li Ke , Zhang Tingting , Wang Ping , Mao Zhiyong , Zhu Weiguo , Xu Xingzhi , Liang Shikang , Lou Zhenkun , Yuan Jian 
Published: May 2024

AbstractDNA damage plays a significant role in the tumorigenesis and progression of the disease. Abnormal DNA repair affects the therapy and prognosis of cancer. In this study, it is demonstrated that the deubiquitinase USP25 promotes non‐homologous end joining (NHEJ), which in turn contributes to chemoresistance in cancer. It is shown that USP25 deubiquitinates SHLD2 at the K64 site, which enhances its binding with REV7 and promotes NHEJ. Furthermore, USP25 deficiency impairs NHEJ‐mediated DNA repair and reduces class switch recombination (CSR) in USP25‐deficient mice. USP25 is overexpressed in a subset of colon cancers. Depletion of USP25 sensitizes colon cancer cells to IR, 5‐Fu, and cisplatin. TRIM25 is also identified, an E3 ligase, as the enzyme responsible for degrading USP25. Downregulation of TRIM25 leads to an increase in USP25 levels, which in turn induces chemoresistance in colon cancer cells. Finally, a peptide that disrupts the USP25‐SHLD2 interaction is successfully identified, impairing NHEJ and increasing sensitivity to chemotherapy in PDX model. Overall, these findings reveal USP25 as a critical effector of SHLD2 in regulating the NHEJ repair pathway and suggest its potential as a therapeutic target for cancer therapy.
Toxicities associated with tyrosine kinase inhibitor maintenance following allogeneic hematopoietic cell transplantation in Philadelphia chromosome‐positive acute lymphoblastic leukemia
Authors: Othman Tamer , Koller Paul , Tsai Ni‐Chun , Yang Dongyun , Pourhassan Hoda , Agrawal Vaibhav , Ngo Dat , Chen Jason , Farol Leonardo , Spielberger Ricardo , Sahebi Firoozeh , Al Malki Monzr M. , Cai Ji‐Lian , Sandhu Karamjeet S. , Mansour Joshua , Salhotra Amandeep , Ali Haris , Aribi Ahmed , Arslan Shukaib , Marcucci Guido , Forman Stephen J. , Stein Anthony S. , Nakamura Ryotaro , Pullarkat Vinod , Aldoss Ibrahim , Mei Matthew 
Published: May 2024

AbstractAllogeneic hematopoietic cell transplantation (HCT) offers a potential cure in Philadelphia chromosome‐positive (Ph+) acute lymphoblastic leukemia (ALL); nonetheless, relapses are common and the major cause of mortality. One strategy to prevent relapse is tyrosine kinase inhibitor (TKI) maintenance post‐HCT, but published clinical experience is primarily with the first‐generation TKI imatinib while data with newer generation TKIs are limited. We conducted a retrospective analysis of 185 Ph+ ALL patients who underwent HCT followed by TKI maintenance from 2003 to 2021 at City of Hope. Initially, 50 (27.0%) received imatinib, 118 (63.8%) received a second‐generation TKI (2G‐TKI), and 17 (9.2%) received ponatinib. A total of 77 patients (41.6%) required a dose reduction of their initial TKI due to toxicity. Sixty‐six patients (35.7%) did not complete maintenance due to toxicity; 69 patients (37.3%) discontinued 1 TKI, and 11 (5.9%) discontinued 2 TKIs due to toxicity. Initial imatinib versus 2G‐TKI versus ponatinib maintenance was discontinued in 19 (38.0%) versus 68 (57.6%) versus 3 (17.6%) patients due to toxicity (p = .003), respectively. Patients on ponatinib as their initial TKI had a longer duration of TKI maintenance versus 2G‐TKI: 576.0 days (range, 72–921) versus 254.5 days (range, 3–2740; p = .02). The most common reasons for initial TKI discontinuation include gastrointestinal (GI) intolerance (15.1%), cytopenia (8.6%), and fluid retention (3.8%). The 5‐year overall survival and progression‐free survival for the total population were 78% and 71%, respectively. Our findings demonstrate the challenges of delivering post‐HCT TKI maintenance in a large real‐world cohort as toxicities leading to TKI interruptions, discontinuation, and dose reduction were common.
Advancements in dementia research, diagnostics, and care in Latin America: Highlights from the 2023 Alzheimer's Association International conference satellite symposium in Mexico City
Authors: Sosa Ana Luisa , Brucki Sonia MD , Crivelli Lucia , Lopera Francisco Javier , Acosta Daisy M , Acosta‐Uribe Juliana , Aguilar Diego , Aguilar‐Navarro Sara G , Allegri Ricardo F , Bertolucci Paulo HF , Calandri Ismael L , Carrillo Maria C , Mendez Patricio Alexis Chrem , Cornejo‐Olivas Mario , Custodio Nilton , Damian Andrés , de Souza Leonardo Cruz , Duran‐Aniotz Claudia , García Adolfo M , García‐Peña Carmen , Gonzales Mitzi M , Grinberg Lea T , Ibanez Agustin M , Illanes‐Manrique Maryenela Zaida , Jack Clifford R , Leon‐Salas Jorge Mario , Llibre‐Guerra Jorge J , Luna‐Muñoz José , Matallana Diana , Miller Bruce L , Naci Lorina , Parra Mario A , Pericak‐Vance Margaret , Piña‐Escudero Stefanie D , França Resende Elisa de Paula , Ringman John M , Sevlever Gustavo , Slachevsky Andrea , Suemoto Claudia Kimie , Valcour Victor , Villegas‐Lanau Andres , Yassuda Mônica S , Mahinrad Simin , Sexton Claire 
Published: May 2024

AbstractINTRODUCTIONWhile Latin America (LatAm) is facing an increasing burden of dementia due to the rapid aging of the population, it remains underrepresented in dementia research, diagnostics, and care.METHODSIn 2023, the Alzheimer's Association hosted its eighth satellite symposium in Mexico, highlighting emerging dementia research, priorities, and challenges within LatAm.RESULTSSignificant initiatives in the region, including intracountry support, showcased their efforts in fostering national and international collaborations; genetic studies unveiled the unique genetic admixture in LatAm; researchers conducting emerging clinical trials discussed ongoing culturally specific interventions; and the urgent need to harmonize practices and studies, improve diagnosis and care, and use affordable biomarkers in the region was highlighted.DISCUSSIONThe myriad of topics discussed at the 2023 AAIC satellite symposium highlighted the growing research efforts in LatAm, providing valuable insights into dementia biology, genetics, epidemiology, treatment, and care.
Considerations for the use of the Informant Questionnaire on Cognitive Decline in the Elderly (IQCODE) in cross‐country comparisons of cognitive aging and dementia
Authors: Nichols Emma , Gross Alden L. , Zhang Yuan S. , Meijer Erik , Hayat Shabina , Steptoe Andrew , Langa Kenneth M. , Lee Jinkook 
Published: May 2024

AbstractINTRODUCTIONInformant reports are a critical component of dementia diagnoses, but the comparability of informant reports across countries is not well understood.METHODSWe compared the performance of the Informant Questionnaire on Cognitive Decline in the Elderly (IQCODE) using population‐representative surveys in the United States (N = 3183), England (N = 1050), and India (N = 4047).RESULTSAnalyses of regression splines and comparisons of model fit showed strong associations between IQCODE and objective cognition at low cognitive functioning in the United States and England; in India, the association was weaker but consistent over the range of cognition. Associations between IQCODE score and informant generation (analysis of variance [ANOVA] p = 0.001), caregiver status (p < 0.001), and years known by the informant (p = 0.015) were different across countries after adjusting for objective cognition.DISCUSSIONIn India, the IQCODE was less sensitive to impairments at the lowest levels of cognitive functioning. Country‐specific adjustments to IQCODE scoring based on informant characteristics may improve cross‐national comparisons.Highlights
Associations between IQCODE and cognitive testing were similar in the United States and England but differed in India.
In India, the IQCODE may be less sensitive to impairments among those with low cognition and no education.
Informant characteristics may differentially impact informant reports of decline across countries.
Adjustments or culturally sensitive adaptations may improve cross‐national comparability.
Ultra‐Large Two‐Dimensional Metal Nanowire Networks by Microfluidic Laminar Flow Synthesis for Formic Acid Electrooxidation
Authors: Zhang Dongtang , Bu Jiahui , Dou Xiangnan , Yan Yong , Liu Qiqi , Wang Xiayan , Sun Zaicheng , Guo Guangsheng , Zheng Kun , Deng Jiguang 
Published: May 2024

AbstractDespite the great research interest in two‐dimensional metal nanowire networks (2D MNWNs) due to their large specific surface area and abundance of unsaturated coordination atoms, their controllable synthesis still remains a significant challenge. Herein, a microfluidics laminar flow‐based approach is developed, enabling the facile preparation of large‐scale 2D structures with diverse alloy compositions, such as PtBi, AuBi, PdBi, PtPdBi, and PtAuCu alloys. Remarkably, these 2D MNWNs can reach sizes up to submillimeter scale (~220 μm), which is significantly larger than the evolution from the 1D or 3D counterparts that typically measure only tens of nanometers. The PdBi 2D MNWNs affords the highest specific activity for formic acid (2669.1 mA mg−1) among current unsupported catalysts, which is 103.5 times higher than Pt‐black, respectively. Furthermore, in situ Fourier transform infrared (FTIR) experiments provide comprehensive evidence that PdBi 2D MNWNs catalysts can effectively prevent CO* poisoning, resulting in exceptional activity and stability for the oxidation of formic acid.
Growing sabers: Mandibular shape and biomechanical performance trajectories during the ontogeny of Smilodon fatalis
Authors: Chatar Narimane , Boman Romain , Fischer Valentin , Segura Valentina , Julémont Clara , Tseng Z. Jack 
Published: May 2024

AbstractThe evolution of organisms can be studied through the lens of developmental systems, as the timing of development of morphological features is an important aspect to consider when studying a phenotype. Such data can be challenging to obtain in fossil amniotes owing to the scarcity of their fossil record. However, the numerous remains of Rancho La Brea allow a detailed study of the postnatal changes in an extinct sabertoothed felid: Smilodon fatalis. Despite numerous previous studies on the ontogeny of Smilodon, an important question remained open: how did the cubs of Smilodon acquire and process food? By applying 3D geometric morphometrics and finite element analyses to 49 mandibles at various developmental stages (22 of S. fatalis, 23 of Panthera leo, and 4 of early diverging felids), we assess the changes in mandibular shape and performance during growth. Both lions and sabertooths exhibit a shift in mandibular shape, aligning with eruption of the lower carnassial. This marks the end of weaning in lions and suggests a prolonged weaning period in S. fatalis owing to its delayed eruption sequence. We also highlight distinct ontogenetic trajectories, with S. fatalis undergoing more postnatal mandibular shape changes. Finally, although S. fatalis appears more efficient than P. leo at performing an anchor bite, this efficiency is acquired through ontogeny and at a quite late age. The delayed shape change compared with P. leo and the low biting efficiency during the growth in Smilodon could indicate an extended duration of the parental care compared with P. leo.
Life outside the LINC complex – Do SUN proteins have LINC‐independent functions?
Authors: Belaadi Nejma , Guilluy Christophe 
Published: May 2024

AbstractSad1 and UNC84 (SUN) and Klarsicht, ANC‐1, and Syne homology (KASH) proteins interact at the nuclear periphery to form the linker of nucleoskeleton and cytoskeleton (LINC) complex, spanning the nuclear envelope (NE) and connecting the cytoskeleton with the nuclear interior. It is now well‐documented that several cellular functions depend on LINC complex formation, including cell differentiation and migration. Intriguingly, recent studies suggest that SUN proteins participate in cellular processes where their association with KASH proteins may not be required. Building on this recent research, we elaborate on the hypothesis that SUN proteins may perform LINC‐independent functions and discuss the modalities that may allow SUN proteins to function at the INM when they are not forming LINC complex.
Fabrication of Nanocatalytic Medicine from Self‐Assembling Peptides Containing an ATCUN‐Like Copper‐Binding Motif for Anticancer Therapy
Authors: Zhang Wenhui , Tian Xin , Li Xinming 
Published: May 2024

AbstractDevelopment of nanomaterials with multiple enzymatic activities via a facile approach receives growing interests in recent years. Although peptide self‐assembling provides an effective approach for the construction of biomimetic materials in recent years, fabrication of artificial enzymes from self‐assembling peptides with multiple catalytic activities for anticancer therapy is still a challenge. Here, we report a simple method to prepare nanocatalysts with multienzyme‐like activities from self‐assembling peptides containing ATCUN copper‐binding motifs. With the aid of the coordination interactions between the ATCUN motif and Cu(II) ions, these peptides could perform supramolecular self‐assembly to form nanomaterials with biomimetic peroxidase, ascorbate oxidase and glutathione peroxidase activities. Moreover, these trienzyme‐like effects can elevate oxidative stress levels and suppress the antioxidative capability of cancer cells, which synergistically induce the apoptosis of cancer cells. Because of the high biocompatibility, catalytic activities and drug encapsulation properties, this self‐assembled peptide provides a biomimetic platform for the development of new nanocatalytic medicines for multimodal synergistic cancer therapies.
Construction of Multiply Guaranteed DNA Sensors for Biological Sensing and Bioimaging Applications
Authors: Wang Hong , Zou Hanyan , Wang Fuan 
Published: May 2024

AbstractNucleic acids exhibit exceptional functionalities for both molecular recognition and catalysis, along with the capability of predictable assembly through strand displacement reactions. The inherent programmability and addressability of DNA probes enable their precise, on‐demand assembly and accurate execution of hybridization, significantly enhancing target detection capabilities. Decades of research in DNA nanotechnology have led to advances in the structural design of functional DNA probes, resulting in increasingly sensitive and robust DNA sensors. Moreover, increasing attention has been devoted to enhancing the accuracy and sensitivity of DNA‐based biosensors by integrating multiple sensing procedures. In this review, we summarize various strategies aimed at enhancing the accuracy of DNA sensors. These strategies involve multiple guarantee procedures, utilizing dual signal output mechanisms, and implementing sequential regulation methods. Our goal is to provide new insights into the development of more accurate DNA sensors, ultimately facilitating their widespread application in clinical diagnostics and assessment.
Aggregation of N‐Heteropolycyclic Aromatic Molecules: The Acridine Dimer and Trimer
Authors: Germer Stefan , Bauer Marco , Hübner Olaf , Dreuw Andreas , Himmel Hans‐Jörg 
Published: May 2024

AbstractPolycyclic aromatic hydrocarbons and their nitrogen‐substituted analogues are of great interest for various applications in organic electronics. The performance of such devices is determined not only by the properties of the single molecules, but also by the structure of their aggregates, which often form via self‐aggregation. Gaining insight into such aggregation processes is a challenging task, but crucial for a fine‐tuning of the materials properties. In this work, an efficient approach for the generation and characterisation of aggregates is described, based on matrix‐isolation experiments and quantum‐chemical calculations. This approach is exemplified for aggregation of acridine. The acridine dimer and trimer are thoroughly analysed on the basis of experimental and calculated UV and IR absorption spectra, which agree well with each other. Thereby a novel structure of the acridine dimer is found, which disagrees with a previously reported one. The calculations also show the changes from excitonic coupling towards orbital interactions between two molecules with decreasing distance to each other. In addition, a structure of the trimer is determined. Finally, an outlook is given on how even higher aggregates can be made accessible through experiment.
Cover Feature: Homogeneous Catalyzed Direct Conversion of Furfural to Gamma‐Valerolactone (ChemSusChem 11/2024)
Authors: Koranchalil Sakhitha , Lobo Justo Pinheiro Danielle , Padilla Rosa , Nielsen Martin 
Published: May 2024

AbstractInvited for this issue's cover is the group of Martin Nielsen at the Technical University of Denmark. The image shows the chemical components of lignocellulose and the transformation of hemicellulose to GVL via furfural. The Research Article itself is available at 10.1002/cssc.202301608.
An area‐effective and low‐power single‐slope ADC for DCG imaging CMOS image sensor
Authors: Yang Rui , Wang Xiuyu , Liu Changju , Ma Biao , Nie Kaiming , Xu Jiangtao 
Published: May 2024

SummaryThis paper introduces an area‐effective and low‐power readout circuit structure tailored for high dynamic range (HDR) CMOS image sensors (CISs) utilizing dual conversion gain (DCG) imaging technology. A switched capacitor amplifier, which is applied at the comparator input port of the column‐parallel single‐slope analog‐to‐digital converter (SS ADC), is proposed to compensate for the charge injection and clock feed‐through introduced when the pixel switches between high conversion gain (HCG) and low conversion gain (LCG) modes. The proposed SS ADC is supplemented by the integration of a configurable counter, and the counter is specifically crafted for performing the A/D conversion of the readout voltage within a DCG pixel. Compared to the conventional DCG readout circuit, the proposed readout circuit use only one ADC for A/D conversion of HCG signals and LCG signals, which greatly reduces the area and power consumption of the readout circuit. Simulation results under 110 nm CMOS technology illustrate that the proposed 10‐bit SS ADC has a DNL of +0.78/−0.91 LSB and an INL of +1.91/−1.69 LSB, with a SNR of 57.2 dB and a SNDR of 55.95 dB, corresponding to an ENOB of 9 bits. The power consumption of the proposed SS ADC is 56.4 μW per column with a conversion time of 12 μs, and the simulation results show that the power consumption is 23.35% lower than the conventional structure and the area is saved by 24.69%.