bluuebunny/crossref_metadata_2025_split huggingface dataset:
A novel CLCN1 mutation (G1652A) causing a mild phenotype of thomsen disease
Authors: Kumar Kishore R. , Ng Karl , Vandebona Himesha , Davis Mark R. , Sue Carolyn M. 
Published: January 2010

AbstractWe investigated a 62‐year‐old man who had mild clinical features of myotonia congenita. He was found to have a novel heterozygous G‐to‐A nucleotide substitution at position 1652 in exon 15 of the CLCN1 gene. Clinicogenetic studies performed on his family revealed that his asymptomatic son also shared the mutation. We conclude that a novel chloride channel mutation (G1652A) has caused a mild form of autosomal‐dominant myotonia congenita (Thomsen disease) in this family. Muscle Nerve, 2010
Sirolimus therapy for fibromatosis and multifocal renal cell carcinoma in a child with tuberous sclerosis complex
Authors: Pressey Joseph G. , Wright Jordan M. , Geller James I. , Joseph David B. , Pressey Christine S. , Kelly David R. 
Published: January 2010

AbstractA male with tuberous sclerosis complex (TSC) developed a chest wall fibromatosis and bilateral multifocal renal cell carcinoma (RCC). The fibromatosis tumor was initially resected during infancy but recurred 5 years later. At that time, bilateral RCC was also detected, leading to the resection of the more extensively affected right kidney. In an attempt to avoid bilateral nephrectomies, the patient was treated with the mTOR inhibitor sirolimus. Within 6 months of therapy, the fibromatosis and remaining RCC tumors responded substantially with minimal adverse effects. Pediatr Blood Cancer 2010;54:1035–1037 © 2010 Wiley‐Liss, Inc.
Initial testing of the aurora kinase a inhibitor MLN8237 by the Pediatric Preclinical Testing Program (PPTP)
Authors: Maris John M. , Morton Christopher L. , Gorlick Richard , Kolb E. Anders , Lock Richard , Carol Hernan , Keir Stephen T. , Reynolds C. Patrick , Kang Min H. , Wu Jianrong , Smith Malcolm A. , Houghton Peter J. 
Published: January 2010

AbstractBackgroundMLN8237 is a small molecule inhibitor of Aurora Kinase A (AURKA) that is currently in early phase clinical testing. AURKA plays a pivotal role in centrosome maturation and spindle formation during mitosis.ProceduresMLN8237 was tested against the Pediatric Preclinical Testing Program (PPTP) in vitro panel at concentrations ranging from 1.0 nM to 10 µM and was tested against the PPTP in vivo panels at a dose of 20 mg/kg administered orally twice daily × 5 days. Treatment duration was 6 weeks for solid tumor xenografts and 3 weeks for ALL xenografts.ResultsMLN8237 had a median IC50 of 61 nM against the PPTP in vitro panel. The ALL cell lines were more sensitive and the rhabdomyosarcoma cell lines less sensitive than the remaining PPTP cell lines. In vivo, MLN8237 induced significant differences in event‐free survival (EFS) distributions compared to controls in 32/40 (80%) solid tumor models and all (6/6) ALL models. Maintained complete responses (CRs) were observed in 3 of 7 neuroblastoma xenografts, and all 6 evaluable ALL xenografts achieved CR (n = 4) or maintained CR (n = 2) status. Maintained CRs were observed among single xenografts in other panels, including the Wilms tumor, rhabdoid tumor, rhabdomyosarcoma, Ewing sarcoma, osteosarcoma, and medulloblastoma.ConclusionsThe in vivo activity observed against the neuroblastoma panel far exceeds that observed for standard agents evaluated against the panel by the PPTP. High levels of in vivo activity were also observed against the ALL xenograft panel. These data support expedited clinical development of MLN8237 in childhood cancer. Pediatr Blood Cancer 2010;55:26–34. © 2010 Wiley‐Liss, Inc.
Physiotherapy management of low back pain in India — a survey of self‐reported practice
Authors: Fidvi Nafisa , May Stephen 
Published: January 2010

AbstractBackground. Physiotherapy is commonly used in the management of low back pain and from previous studies appears to be eclectic and not always in line with evidence‐based practice. Most previous studies have been conducted in Western countries, and no previous studies have sought to explore physiotherapy management of low back pain in India. Purpose. The aim of this study was to explore the self‐reported management strategies employed by physiotherapists in India as it is unknown if these are in line with contemporary guidelines. Methods. Study design was a self‐completed questionnaire, which was sent to the 350 physiotherapists registered with the Indian Physiotherapy Association in the state of Maharashtra in India. To maximize response rate there was repeat e‐mailing and telephone follow‐up. Results. Thirty‐eight therapists did not treat patients with back pain and 45 were not working in India and so were excluded. Out of a sample frame of 267 physiotherapists, 186 responded to the e‐mailed questionnaire (70%). All therapists reported that they gave some kind of advice to patients, used exercises and electrotherapy, and in addition about half used manual therapy. The majority of therapists used 8–12 sessions of treatment. Conclusions. This first mapping of Indian physiotherapy management of low back pain has shown several areas of ‘good practice’ in line with contemporary guidelines. It also highlighted potential areas of concern regarding evidence‐based practice; namely, very common use of passive electrotherapy modalities and potential excessive treatment. This report has implications for physiotherapy practice and education in India. Copyright © 2010 John Wiley & Sons, Ltd.
Improving operating discipline through the successful implementation of a mandated behavior‐based safety program
Authors: Vaughen Bruce K. , Lock Kelly J. , Floyd Timothy K. 
Published: January 2010

AbstractThis article describes the improvement of a manufacturing site's safety performance that can be attributed, in part, to the successful implementation of a mandated behavior‐based safety (BBS) program. As has been discussed in prior articles, improving operating discipline (improving the conduct of operations) will contribute to reducing process safety, health and environmental risks. The BBS program implementation, with its expectation that each employee complete and submit at least one safety observation a month, coincided with several other significant safety initiatives. These other initiatives required employee involvement from all levels of the organization, including implementing process safety management elements, implementing the site's “principles of operation,” and performing daily job safety analyses. This article will describe how the site's BBS observation program has evolved over the last decade, how several human‐related issues were overcome, and provides specific examples of some of the changes implemented as a result of the observations. In conclusion, this article shows how direct management involvement and support and increased personnel involvement has improved safety awareness, knowledge, and commitment to help reduce manufacturing risks.“You can observe a lot just by watching.”—Yogi Berra © 2010 American Institute of Chemical Engineers Process Saf Prog, 2010
Highly conductive and optically transparent GZO films grown under metal‐rich conditions by plasma assisted MBE
Authors: Liu H. Y. , Avrutin V. , Izyumskaya N. , Reshchikov M. A. , Özgür Ü. , Morkoç H. 
Published: January 2010

AbstractWe demonstrate a critical effect of a metal‐to‐oxygen ratio on the electrical, optical, and structural properties of ZnO films heavily doped with Ga (carrier concentration in the range of 1020–1021 cm–3) grown by plasma‐assisted molecular beam epitaxy. The as‐grown layers prepared under the metal‐rich conditions exhibited resistivities below 3 × 10–4 Ω cm and an optical transparency exceeding 90% in the visible spectral range as well as a large blue shift of the transmission/absorption edge attributed to the Burstein–Moss shift of the Fermi level deep into the conduction band, indicating high donor concentration. In contrast, the films grown under the oxygen‐rich conditions required thermal activation and showed inferior properties. Furthermore, electrical measurements point to the nonuniform depth distribution of free carriers. An oxygen‐pressure‐dependent surface disordering is suggested to be responsible for the drastic effect of the metal‐to‐oxygen ratio on the film properties. (© 2010 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
A note on boundary‐layer friction in baroclinic cyclones
Authors: Boutle I. A. , Beare R. J. , Belcher S. E. , Plant R. S. 
Published: January 2010

AbstractThe interaction between extratropical cyclones and the underlying boundary layer has been a topic of recent discussion in papers by Adamson et al. (2006) and Beare (2007). Their results emphasize different mechanisms through which the boundary‐layer dynamics may modify the growth of a baroclinic cyclone. By using different sea‐surface temperature distributions and comparing the low‐level winds, the differences are exposed and both of the proposed mechanisms appear to be acting within a single simulation. Copyright © 2007 Royal Meteorological Society
Quantitative evaluation of catalytic effect of metal chlorides on the decomposition reaction of NaAlH4
Authors: Hirate Hiroshi , Saito Yuki , Nakaya Ippei , Sawai Hiroshi , Yukawa Hiroshi , Morinaga Masahiko , Nakai Hiromi 
Published: January 2010

AbstractThe hydrogen desorption (or decomposition) reaction of NaAlH4 is expressed as $ {\rm NaAlH_4} \rightarrow {1/3} {\rm Na_3AlH_6} + {2/3} {\rm Al + H_2} $, and its desorption rate is accelerated by mixing metal chloride catalysts (e.g., TiCl3). This catalytic effect of metal chlorides, MCln, is theoretically estimated in a quantitative way using atomization energy concept. The atomization energies, ΔEM for metal ion and ΔECl for chloride ion in various metal chlorides are evaluated using the energy density analysis of the total energy. It is shown that the hydrogen desorption reaction rate increases with increasing n × ΔEM values of metal chlorides. This indicates that the metal ion in MCln interacts mainly with hydrogen or [AlH4]− complex anion in NaAlH4. To confirm this calculated result, experiments are performed using NaAlH4 mixed with Ti‐based catalysts. The hydrogen desorption rate is enhanced in the order, TiCl3 > TiO2 > Ti metal nanopowder, indicating that the Ti ions in TiCl3 or TiO2 work to promote the catalytic reaction more effectively than the neutral Ti atoms in Ti metal nanopowder. © 2010 Wiley Periodicals, Inc. Int J Quantum Chem, 2011
Nitrogen and Luminescent Nitrogen‐Vacancy Defects in Detonation Nanodiamond
Authors: Vlasov Igor I. , Shenderova Olga , Turner Stuart , Lebedev Oleg I. , Basov Artem A. , Sildos Ilmo , Rähn Mickel , Shiryaev Andrey A. , Van Tendeloo Gustaaf 
Published: January 2010

AbstractAn efficient method to investigate the microstructure and spatial distribution of nitrogen and nitrogen‐vacancy (N‐V) defects in detonation nanodiamond (DND) with primary particle sizes ranging from approximately 3 to 50 nm is presented. Detailed analysis reveals atomic nitrogen concentrations as high as 3 at% in 50% of diamond primary particles with sizes smaller than 6 nm. A non‐uniform distribution of nitrogen within larger primary DND particles is also presented, indicating a preference for location within the defective central part or at twin boundaries. A photoluminescence (PL) spectrum with well‐pronounced zero‐phonon lines related to the N‐V centers is demonstrated for the first time for electron‐irradiated and annealed DND particles at continuous laser excitation. Combined Raman and PL analysis of DND crystallites dispersed on a Si substrate leads to the conclusion that the observed N‐V luminescence originates from primary particles with sizes exceeding 30 nm. These findings demonstrate that by manipulation of the size/nitrogen content in DND there are prospects for mass production of nanodiamond photoemitters based on bright and stable luminescence from nitrogen‐related defects.
SERS‐Based Diagnosis and Biodetection
Authors: Alvarez‐Puebla Ramón A. , Liz‐Marzán Luis M. 
Published: January 2010

AbstractSurface‐enhanced Raman scattering (SERS) spectroscopy is one of the most powerful analytical techniques for identification of molecular species, with the potential to reach single‐molecule detection under ambient conditions. This Concept article presents a brief introduction and discussion of both recent advances and limitations of SERS in the context of diagnosis and biodetection, ranging from direct sensing to the use of encoded nanoparticles, in particular focusing on ultradetection of relevant bioanalytes, rapid diagnosis of diseases, marking of organelles within individual cells, and non‐invasive tagging of anomalous tissues in living animals.
Catalytic Nanomotors: Self‐Propelled Sphere Dimers
Authors: Valadares Leonardo F. , Tao Yu‐Guo , Zacharia Nicole S. , Kitaev Vladimir , Galembeck Fernando , Kapral Raymond , Ozin Geoffrey A. 
Published: January 2010

AbstractExperimental and theoretical studies of the self‐propelled motional dynamics of a new genre of catalytic sphere dimer, which comprises a non‐catalytic silica sphere connected to a catalytic platinum sphere, are reported for the first time. Using aqueous hydrogen peroxide as the fuel to effect catalytic propulsion of the sphere dimers, both quasi‐linear and quasi‐circular trajectories are observed in the solution phase and analyzed for different dimensions of the platinum component. In addition, well‐defined rotational motion of these sphere dimers is observed at the solution–substrate interface. The nature of the interaction between the sphere dimer and the substrate in the aqueous hydrogen peroxide phase is discussed. In computer simulations of the sphere dimer in solution and the solution–substrate interface, sphere‐dimer dynamics are simulated using molecular‐dynamics methods and solvent dynamics are modeled by mesoscopic multiparticle collision methods taking hydrodynamic interactions into account. The rotational and translational dynamics of the sphere dimer are found to be in good accord with the predictions of computer simulations.
Superhard Nanobuttons: Constraining Crystal Plasticity and Dealing with Extrinsic Effects at the Nanoscale
Authors: Rinaldi Antonio , Peralta Pedro , Friesen Cody , Nahar Dhiraj , Licoccia Silvia , Traversa Enrico , Sieradzki Karl 
Published: January 2010

AbstractThe compressive plastic strength of nanosized single‐crystal metallic pillars is known to depend on their diameter D. Herein, the role of pillar height h is analyzed instead, and the suppression of the generalized crystal plasticity below a critical value hCR is observed. Novel in situ compression tests on regular pillars as well as nanobuttons, that is, pillars with h < hCR, show that the latter are much harder, withstanding stresses >2 GPa. A statistical model that holds for both pillars and buttons is formulated. Owing to their superhard nature, the nanobuttons examined here underline with unprecedented resolution the extrinsic effects—often overlooked—that naturally arise during testing when the Saint‐Venant assumption ceases to be accurate. The bias related to such effects is identified in the test data and removed when possible. Finally, continuous hardening is observed to occur under increasing stress level, in analogy to reports on nanoparticles. From a metrological standpoint the results expose some difficulties in nanoscale testing related to current methodology and technology. The implications of the analysis of extrinsic effects go beyond nanobuttons and extend to nano‐/microelectromechanical system design and nanomechanics in general.
An Intermolecular Hydrogen Bridge between a Porphyrinoid μ‐Oxido Diiron(III) Host and a Guest Water Molecule
Authors: Bröring Martin , Ostapowicz Thomas , Funk Markus 
Published: January 2010

Abstractμ‐Oxido‐bis[(hexaethyldimethyl‐2,2′‐bidipyrrinato)iron(III)] (1) crystallizes as a mixed dichloromethane/water solvate as black plates in the triclinic system, space group P\bar{1}, with a = 14.536(3), b = 16.194(3), c = 25.883(5) Å, α = 98.89(3)°, β = 91.28(3)°, γ = 90.56(3)°, and Z = 2. In the crystal structure two distinct solvates 1·CH2Cl2 and 1·H2O are present in equal ratio. In both cases the solvent is found in direct vicinity of the Fe–O–Fe subunit and is located within a binding pocket formed by the two helically distorted tetrapyrroles. Whereas the dichloromethane molecule is oriented within this pocket as a dipole with the positive end pointing towards the oxygen atom of the Fe–O–Fe subunit, the water molecule forms a hydrogen bond with this site, supported by additional weak interactions with adjacent N‐donor atoms.
Infinite Coordination Polymers of One‐ and Two‐dimensional Cobalt Acetates
Authors: Zhang Gao , Lin Jian , Guo Dong‐Wei , Yao Shi‐Yan , Tian Yun‐Qi 
Published: January 2010

AbstractTwo coordination polymers of cobalt acetate, [Co5(O2CMe)10] (1) and [Co(O2CMe)2(H2O)]·H2O (2), were solvothermally synthesized and characterized by single‐crystal and powder X‐ray diffraction analyses, IR spectroscopy, and elemental analysis. Compound 1 crystallizes in orthorhombic space group Pbcn in two‐dimensional layers, which consist of 12‐membered cobalt rings. Compound 2 crystallizes in monoclinic space group C2/m and exhibits one‐dimensional chains, which are bridged by one water molecule and two acetate ligands in (2.11)‐ and (2.20)‐modes. Preliminary magnetic studies revealed that antiferromagnetic couplings exist in both compounds.
Tri(mesityloxy)silanethiol – The First Structurally Characterized Organoxysilanethiol (Contributions to the Chemistry of Silicon–Sulfur Compounds. 77 [1])
Authors: Marynowski Wojciech , Klucznik Tomasz , Baranowska Katarzyna , Dołęga Anna , Wojnowski Wiesław 
Published: January 2010

AbstractTri(mesityloxy)silanethiol (TMST) was isolated as the only product of the reaction between SiS2 and 2,4,6‐trimethylphenol. TMST crystallizes in the triclinic system. Good quality of the crystal allowed the unrestricted refinement of the mercapto group; the resulting S–H distance is 1.29(4) Å and the Si–S–H bond angle is 95.4(17)°. Molecules of TMST show no hydrogen bonds in the crystal – the FT‐IR spectrum of the solid sample exhibits a very sharp, well‐resolved band of isolated –SH group at 2562 cm–1.
Multitraces, hypertraces and partial order semantics
Authors: Shields M. W. 
Published: January 2010

Abstract
In this paper, we consider a generalisation of a result due to the author which describes the way in which Mazurkiewicz trace languages serve to represent systems of labelled partial orders, as used in non-interleaving semantics of parallelism. The generalisation extends the class of partial order systems to exclude only a form of non-determinism. Their representation is in terms ofa generalisation of traces, also due to Mazurkiewicz, called multi traces.
Biofeedback Therapy Plus Anal Electrostimulation for Fecal Incontinence: Prognostic Factors and Effects on Anorectal Physiology
Authors: Boselli Adamo Stefano , Pinna Ferdinando , Cecchini Stefano , Costi Renato , Marchesi Federico , Violi Vincenzo , Sarli Leopoldo , Roncoroni Luigi 
Published: January 2010

AbstractBackgroundThe current literature does not provide unequivocal data on prognostic factors in conservative management of fecal incontinence. Moreover, the physiopathologic effects of pelvic floor rehabilitation on anorectal function are not well understood. Our aim is to identify some prognostic parameters and assess their effects on anorectal physiology of biofeedback therapy plus anal electrostimulation for fecal incontinence.MethodsWe studied prospectively 45 consecutive adult patients with fecal incontinence treated at our institution with biofeedback plus electrostimulation. The outcome parameter was modification of the Wexner Incontinence Score (WIS) at the end of treatment. In addition, we studied the modifications of anorectal manometry and the rectal sensitivity threshold after treatment.ResultsAt univariate analysis, age, the pretreatment WIS, and the pretreatment resting and maximum squeeze pressures were correlated with the clinical outcome. Patients showed a significant reduction in the rectal sensitivity threshold but no significant change in manometric parameters after treatment.ConclusionsWe identify good sphincter function and mild to moderate symptomatology as favorable prognostic factors in biofeedback and anal electrostimulation therapy. Improvement in rectal sensitivity can be implicated in symptomatic improvement. The impossibility of correlating the clinical results with the effects on anorectal physiology suggests a nonspecific effect of conservative treatment.
Outcomes of Multimodality Breast Screening for Women at Increased Risk of Familial Breast Cancer
Authors: Bennett Ian C. , Muller Jennifer , Cockburn Linda , Joshua Helen , Thorley Gillian , Baker Christine , Wood Nili , Brazier Jane , Jones Mark , Dunn Nathan , Gattas Michael 
Published: January 2010

AbstractBackgroundWhile population‐based breast screening for women over the age of 50 years is a generally accepted and proven health strategy, the role of breast screening specifically among women at high risk of familial breast cancer has remained controversial. Indeed, there are very few services specifically offering a breast‐screening program for women at high risk of familial breast cancer.MethodsIn 1999 a Familial Breast Cancer Screening Clinic (FBCSC) was established at the North Brisbane BreastScreen Queensland Service to provide a regular multimodality screening program utilizing clinical breast examination, breast ultrasound, and mammography for women at higher risk of hereditary breast cancer and with entry into the program commencing from the age of 30 years.ResultsSince its inception, a total of 2440 women have participated in the FBCSC. A total 7051 breast‐screening examinations have been performed on these participants, with 53 breast cancers being diagnosed, including 8 in situ ductal carcinomas, 38 invasive ductal carcinomas, and 7 invasive lobular carcinomas. The mean size of the cancers was 16 mm (range = 1–45 mm), and of the 45 invasive cancers, 60% were less than or equal to 15 mm in size. The overall axillary node positive rate was 24.5% (13/53). The invasive cancer detection rate for first‐round screening was 8.3 cancers per 1000 women screened, with 5.2 cancers per 1000 women detected on subsequent round screening.ConclusionsThe results from this service demonstrate that multimodality screening for women at high risk of familial breast cancer and including women of younger age is effective and appropriate, with very acceptable cancer detection rates and pathological cancer characteristics being observed consistent with early‐stage detection. The colocated siting of this service within a BreastScreen Queensland facility has proven to be efficient and cost effective.