bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical outcomes of milled, 3D‐printed, and conventional complete dentures in edentulous patients: A systematic review and meta‐analysis
Authors: Zandinejad Amirali , Floriani Franciele , Lin Wei‐Shao , Naimi‐Akbar Aron 
Published: April 2024

AbstractPurposeThis systematic review aims to compare clinical outcomes of digital dentures with conventional dentures.Materials and MethodsThis study followed the Preferred Reporting Items for Systematic Reviews and Meta‐Analyses (PRISMA) guidelines and was registered in Prospero. The formulated population, intervention, comparison, outcome (PICO) question was “What is the clinical outcome of digital versus conventional complete dentures (CDs) in edentulous patients?”. The search strategy used three main electronic databases and an additional manual search was completed in August 2023 by following an established search strategy. Initial inclusion was based on titles and abstracts, followed by a detailed review of selected studies, and clinical studies that evaluated the clinical outcome of digital (milled or 3D‐printed) versus conventional CDs were included. A qualitative analysis for clinical studies was used to assess the risk of bias. The certainty of the evidence was assessed according to the grading of recommendations, assessment, development, and evaluations (GRADE) system. In addition, a single‐arm meta‐analysis was performed to evaluate the retention between digital versus conventional CDs.ResultsThe initial search yielded a total of 947 articles, out of which 19 were selected for a comprehensive review, and six met the eligibility criteria to be included in this systematic review. The computer‐aided design and computer‐aided manufacturing (CAD‐CAM) CDs showed increased retention, no relevant differences in oral health‐related quality of life (OHRQoL), and shorter working time compared to conventional dentures. Two studies were eligible for meta‐analysis; retention was significantly better among CAD‐CAM fabricated dentures (standardized mean difference [SMD] 0.501) than conventional dentures. The heterogeneity between studies was high (95% CI: 0.049–0.952).ConclusionsClinically, both the milled and the 3D‐printed CD fared better than conventional dentures in terms of retention, reduction in the number of appointments, improved patient comfort, and improved predictable maintenance of the denture. Patients' perceptions and satisfaction were independent of the digital and conventional fabricated dentures.
Drivers of plant parasitic nematode community structures associated with tobacco‐growing areas in southern Brazil
Authors: de Ramos Eduarda Kalena Kirsch , Pazdiora Paulo Cesar , Dallagnol Leandro Jose , Pereira Matheus Martins , de Souza Mayara Rodrigues , de Araujo Filho Jeronimo Vieira 
Published: April 2024

AbstractTobacco (Nicotiana tabacum L.) is one of the most important crops in southern Brazil, but little is known about the distribution and diversity of plant parasitic nematodes (PPNs). We surveyed the occurrence and diversity of PPNs in 36 tobacco‐growing areas in southern Brazil as well as evaluated their relationship with 19 bioclimatic variables. For these purposes, extracted nematodes (from soil and roots) were identified based on morphological and biochemical traits and estimates of incidence and abundance were obtained, which were used to compute diversity indices. Furthermore, the relationship between taxa and diversity and the influence of bioclimatic variables were studied using principal component analysis (PCA) and generalized linear models (GLMs), respectively. We observed diversity across the sampled sites, with values varying from 0.03 to 1.22 and from 0.05 to 0.76 according to the Shannon‐Wiener and Pielou's evenness indices, respectively. Seven genera of PPNs (Meloidogyne, Helicotylenchus, Tylenchus, Xiphinema, Pratylenchus, Paratylenchus and Mesocriconema) were identified, highlighting taxa with high incidence and abundance, such as Meloidogyne (100%; 1800 to 41,850 specimens/250 cm3), Helicotylenchus (100%; 50 to 9850 specimens/250 cm3), and Pratylenchus (86.1%; 50 to 1950 specimens/250 cm3). The PCA disclosed the major roles of Meloidogyne, Tylenchus, and Helicotylenchus in the structure of the PPN communities and their interplays. Among root‐knot nematodes, Meloidogyne javanica, M. arenaria and M. incognita were the predominant species. Using GLMs, we found that average annual temperature and annual precipitation strongly influenced the abundance of PPNs as well as the diversity indices (p < .01), with negative and/or positive interactions. Collectively, our findings fill gaps in knowledge about the current impact of PPNs and provide insights into future scenarios, including for other host crops.
Performance, digestibility and meat quality from lambs fed diets with plantago lanceolata, Italian ryegrass or sainfoin herbages
Authors: Kara Kanber , Yilmaz Sena , Gerçekaslan Kamil Emre , Özkaya Serkan 
Published: April 2024

AbstractPlantago species, which is known to adapt to different climatic conditions, drought, temperature and different soil types. The aim of this study was to compare the effects of P. lanceolata herbage on fattening performance, rumen variables, digestibility, meat quality, meat nutrients and meat textural variables in lambs with the values of Italian ryegrass and sainfoin herbages. The lambs were fed total mix ration (TMR) with concentrated feed (about 30%) plus forage (about 70%) (P. lanceolata, PLA, Italian ryegrass (Lolium multiflorum); IRY or sainfoin (Onobrychis viciifolia) herbages, SAI). Twenty‐four male lambs (Akkaraman breed) were assigned to three treatments with 8 lambs in each group. Fattening performance parameters, digestibility and carcass variables were determined. Meat quality and shelf life variables (oxidation, fatty acid profile and textural variables) was detected in the loin (Musculus longissimus), shoulder (M. deltoideus) and leg (M. semitendinosus) muscle samples, which were rested for 24 h +4°C and stored at −20°C for one week, one month, three months and six months. The dry matter (DM) intake, body weight gain, feed efficiency and carcass yield values of lambs, the DM and organic matter (OM) digestions (DMD and OMD) of TMRs, and the pH value, ammonia‐nitrogen and short chain fatty acid (SCFA) concentrations of rumen fluid in lambs consuming PLA were similar to those of IRY and SAI (p > 0.05). PLA increased water holding capacity (WHC) and decreased cooking loss of meat compared to feeding with those of IRY and SAI (p < 0.05). The peroxide value (PV) and malondialdehyde (MDA) concentration increased with the stocking time in the meats (p < 0.05). Therefore, PV and MDA concentrations of shoulder, leg and loin meats up to 6th months for PLA were lower than those of IRY and SAI (p < 0.05). The linoleic acid concentration of loin and shoulder meats in PLA were higher than those of IRY and SAI (p < 0.05). The average oleic acid and ∑ω6 fatty acids concentration of meat in PLA was lower than those in IRY and SAI (p < 0.05). Atherogenic index and thrombogenic index values and palmitic acid levels of meat in PLA were similar to those in IRY, but lower than those in SAI (p < 0.05). Springiness, cohesiveness, resilience, hardness and chewiness values of the textural analysis parameters in meat of PLA were lower than those of IRY and SAI. As a result, effect of P. lanceolata on the fattening performance and rumen fermentation of lambs were similar with those of Italian ryegrass (Gramineae family) and sainfoin (Leguminosae family) forages and, it had a positive effect on meat quality (water holding capacity, cooking loss) and meat shelf life criteria (MDA, PV, fatty acid profile and textural variables). For functional lamb meat production, P. lanceolata can be included in the diet of lamb fattening.
A study on the distribution, origin, and taxonomy of Populus pseudoglauca and Populus wuana
Authors: Mi Jia‐Xuan , Huang Jin‐Liang , Shi Yu‐Jie , Tian Fei‐Fei , Li Jing , Meng Fan‐Yu , He Fang , Zhong Yu , Yang Han‐Bo , Zhang Fan , Chen Liang‐Hua , Wan Xue‐Qin 
Published: April 2024

AbstractTaxonomy of Populus is a challenging task, especially in regions with complex topography, such as the Qinghai–Tibet Plateau because of the effect of hybridization, incomplete lineage sorting, phenotypic plasticity, and convergence. In the Flora of China, Populus pseudoglanca and Populus wuana are classified into sect. Leucoides and sect. Tacamahaca, respectively, but their taxonomy remains unclear. By conducting a systematic investigation for all taxa of Populus on the plateau, we found 31 taxa from the two sections. Through identification based on morphology and habitats, we confirmed that the “P. pseudoglanca” recorded in the Flora of Sichuan is not true P. pseudoglanca, while P. pseudoglanca and P. wuana recorded in the Flora of China may refer to the same species. By performing whole‐genome re‐sequencing of 150 individuals from the 31 taxa, we derived 2.28 million single nucleotide polymorphisms (SNPs). Further genetic and phylogenetic analyses demonstrated that the genetic structure of P. wuana is extremely consistent with P. pseudoglanca, and they all originate through the natural hybridization between Populus ciliata in sect. Leucoides and Populus curviserrata in sect. Tacamahaca. Our results suggested that P. wuana should be merged with P. pseudoglanca taxonomically. This study not only clarifies the taxonomic confusions related to P. pseudoglanca and P. wuana but also provides a new framework based on the integration of morphology, distribution, habitat, and genome to solve complex taxonomic problems.
House of CarDs: Functional insights into the transcriptional regulator CdnL
Authors: Smith Erika L. , Goley Erin D. 
Published: April 2024

AbstractRegulation of bacterial transcription is a complex and multi‐faceted phenomenon that is critical for growth and adaptation. Proteins in the CarD_CdnL_TRCF family are widespread, often essential, regulators of transcription of genes required for growth and metabolic homeostasis. Research in the last decade has described the mechanistic and structural bases of CarD‐CdnL‐mediated regulation of transcription initiation. More recently, studies in a range of bacteria have begun to elucidate the physiological roles of CarD‐CdnL proteins as well as mechanisms by which these proteins, themselves, are regulated. A theme has emerged wherein regulation of CarD‐CdnL proteins is central to bacterial adaptation to stress and/or changing environmental conditions.
A patient presenting downbeat positioning nystagmus with 19/11 CAG repeats in the CACNA1A gene: A case report
Authors: Yaguchi Hiroaki , Abe Megumi , Fujiwara Keishi , Kudo Akihiko , Naganuma Ryoji , Uwatoko Hisashi , Shirai Shinichi , Takahashi‐Iwata Ikuko , Matsushima Masaaki , Yabe Ichiro 
Published: April 2024

AbstractSpinocerebellar ataxia type 6 (SCA6) is a polyglutamine disorder caused by the expansion of CAG repeats in the gene encoding voltage‐gated calcium channel subunit alpha1 A (CACNA1A). The clinical features of SCA6 include slowly progressive cerebellar ataxia and downbeat positioning nystagmus. The clinical significance of 19 CAG repeats is unclear. We report a case with 19/11 CAG repeats in CACNA1A determined by direct sequencing. The case presented with DPN, which is one of the most important symptoms of SCA6, but did not present with ataxia.
SCPL acyltransferases catalyze the metabolism of chlorogenic acid during purple coneflower seed germination
Authors: Huang Yuqing , Wang Hsihua , Zhang Yuting , Zhang Pingyu , Xiang Yuting , Zhang Yang , Fu Rao 
Published: April 2024

Summary

The metabolism of massively accumulated chlorogenic acid is crucial for the successful germination of purple coneflower (Echinacea purpurea (L.) Menoch). A serine carboxypeptidase‐like (SCPL) acyltransferase (chicoric acid synthase, CAS) utilizes chlorogenic acid to produce chicoric acid during germination. However, it seems that the generation of chicoric acid lags behind the decrease in chlorogenic acid, suggesting an earlier route of chlorogenic acid metabolism.

We discovered another chlorogenic acid metabolic product, 3,5‐dicaffeoylquinic acid, which is produced before chicoric acid, filling the lag phase. Then, we identified two additional typical clade IA SCPL acyltransferases, named chlorogenic acid condensing enzymes (CCEs), that catalyze the biosynthesis of 3,5‐dicaffeoylquinic acid from chlorogenic acid with different kinetic characteristics.

Chlorogenic acid inhibits radicle elongation in a dose‐dependent manner, explaining the potential biological role of SCPL acyltransferases‐mediated continuous chlorogenic acid metabolism during germination. Both CCE1 and CCE2 are highly conserved among Echinacea species, supporting the observed metabolism of chlorogenic acid to 3,5‐dicaffeoylquinic acid in two Echinacea species without chicoric acid accumulation.

The discovery of SCPL acyltransferase involved in the biosynthesis of 3,5‐dicaffeoylquinic acid suggests convergent evolution. Our research clarifies the metabolism strategy of chlorogenic acid in Echinacea species and provides more insight into plant metabolism.
Assessing the potential economic effects of mesopelagic fisheries as a novel source of fishmeal
Authors: Gowda Thanh Quang Rohan , Kourantidou Melina , Jin Di 
Published: April 2024

AbstractThe continuous growth of the aquaculture industry implies increased demand for efficient sources of aquafeed, such as fishmeal. Pelagic fish are a desirable source of fishmeal due to their high nutritional content. Nevertheless, several pelagic stocks that have been exploited extensively for fishmeal production face ecological limits due to commercial exploitation, and the aquaculture industry is now seeking novel, efficient, and sustainable sources of aquafeed. The mesopelagic zone, an ecosystem with many scientific uncertainties, is being considered as a potential source for fishmeal, largely owing to the abundance of mesopelagic fish and their robust nutritional profile. However, both the ecological and economic viability of commercial exploitation of mesopelagic fish are not yet well understood. To understand the conditions that would make such an endeavor economically viable in the context of global fishmeal production systems, we use a bioeconomic model that assesses the economic consequences of including mesopelagic fish as a fishmeal source. Through simulations, we assess the economic implications of this hypothetical mesopelagic fishery on major pelagic fishmeal production systems. The mesopelagic fishery can be economically profitable for harvesters, and its addition to global fishmeal production reduces fishmeal market price, thus making it more accessible to aquaculture farmers and less profitable for pelagic fishers. While this may reduce fishing pressure on pelagic forage‐fish stocks, the implications of commercial exploitation of mesopelagic on key ecosystem services remain a concern.
Determinants of Kuwait long‐run and short‐run economic growth
Authors: Alawadhi Ahmad , Salih Siddig , Aljaber Abdullah , Al‐Qudsi Sulayman 
Published: April 2024

AbstractThis paper examined the relationship between growth and its demand side determinants in Kuwait from 1970 to 2020. A set of autoregressive distributed lag models were applied to estimate the long‐ and short‐run relationships between economic growth and its determinants. The results suggest that exports, gross fixed capital formation (investment), imports and household spending exhibit a long‐run relationship with economic growth. While exports, gross fixed capital formation, share of government spending in GDP and household spending exhibit short‐run relationship with growth. Moreover, the results suggest that long‐ and short‐run economic growth in Kuwait is mainly driven by exports and to a lesser extent household spending. As Kuwaiti exports are dominated by oil exports and oil production is limited to the organisation of petroleum exporting countries quota this limits the policy makers from the most effective tool to stimulate growth. In this context Kuwait needs to enact policies to diversify exports, build a local industrial base, utilise imports to feed into non‐oil export sectors, direct investment spending to develop non‐oil industries and encourage FDI to facilitate innovation and technology transfers and spill overs to progress from a volatile oil‐based economy to a more diversified and sustainable growth path.
The Influence of Radiographic Parameter on the S2 Alar‐Iliac Screw Virtual Trajectory in Degenerative Lumbar Scoliosis Patients: A Computed Tomography Study
Authors: Jiang Jun , Song Chenyu , Wang Han , Qiu Yong , Wang Bin , Zhu Zezhang , Yu Yang 
Published: April 2024

ObjectiveS2 alar‐iliac (S2AI) screw had been widely used in the pelvic fusion for degenerative lumbar scoliosis (DLS) patients. However, whether S2AI screw trajectory was influenced by sagittal profile in DLS patients had not been comprehensively investigated. The objective of this study was to evaluate the associations between the optimal S2 alar‐iliac (S2AI) screw trajectory and sagittal spinopelvic parameters in DLS patients.MethodsComputed tomography (CT) scans of pelvis were performed in 47 DLS patients for three‐dimensional reconstruction of S2AI screw trajectory from September 2019 to November 2021. Five S2AI screw trajectory parameters were measured in CT reconstruction images, including: 1) angle in the transverse plane (Tsv angle); 2) angle in the sagittal plane (Sag angle); 3) maximal screw length; 4) screw width; and 5) skin distance. The lumbar Cobb angle, lumbar apical vertebral translation (AVT); global kyphosis (GK); thoracic kyphosis (TK); lumbar lordosis (LL); sagittal vertical axis (SVA); sacral slope (SS); pelvic tilt (PT); and pelvic incidence (PI) were measured in standing X‐ray films of the whole spine and pelvis.ResultsBoth Tsv angle and Sag angle had significant positive associations with SS (p < 0.05) but negative associations with both PT (p < 0.05) and LL (p < 0.05) in all cases. Patients with SS less than 15° had both smaller Tsv angle and Sag angle than those with SS equal to or more than 15° (p < 0.05). The decreased LL would lead to the backward rotation of the pelvis, resulting in a more cephalic and less divergent trajectory of S2AI screw in DLS patients.ConclusionsFor DLS patients with lumbar kyphosis, spine surgeons should avoid both excessive Tsv and Sag angles for S2AI screw insertion, especially when using free‐hand technique.
Recommendations for asthma monitoring in children: A PeARL document endorsed by APAPARI, EAACI, INTERASMA, REG, and WAO
Authors: Papadopoulos Nikolaos G. , Custovic Adnan , Deschildre Antoine , Gern James E. , Nieto Garcia Antonio , Miligkos Michael , Phipatanakul Wanda , Wong Gary , Xepapadaki Paraskevi , Agache Ioana , Arasi Stefania , Awad El‐Sayed Zeinab , Bacharier Leonard B. , Bonini Matteo , Braido Fulvio , Caimmi Davide , Castro‐Rodriguez Jose A. , Chen Zhimin , Clausen Michael , Craig Timothy , Diamant Zuzana , Ducharme Francine M. , Ebisawa Motohiro , Eigenmann Philippe , Feleszko Wojciech , Fierro Vincezo , Fiocchi Alessandro , Garcia‐Marcos Luis , Goh Anne , Gómez René Maximiliano , Gotua Maia , Hamelmann Eckard , Hedlin Gunilla , Hossny Elham M. , Ispayeva Zhanat , Jackson Daniel J. , Jartti Tuomas , Jeseňák Miloš , Kalayci Omer , Kaplan Alan , Konradsen Jon R. , Kuna Piotr , Lau Susanne , Le Souef Peter , Lemanske Robert F. , Levin Michael , Makela Mika J. , Mathioudakis Alexander G. , Mazulov Oleksandr , Morais‐Almeida Mário , Murray Clare , Nagaraju Karthik , Novak Zoltan , Pawankar Ruby , Pijnenburg Marielle W. , Pite Helena , Pitrez Paulo M. , Pohunek Petr , Price David , Priftanji Alfred , Ramiconi Valeria , Rivero Yeverino Daniela , Roberts Graham , Sheikh Aziz , Shen Kun‐Ling , Szepfalusi Zsolt , Tsiligianni Ioanna , Turkalj Mirjana , Turner Steve , Umanets Tetiana , Valiulis Arunas , Vijveberg Susanne , Wang Jiu‐Yao , Winders Tonya , Yon Dong Keon , Yusuf Osman M. , Zar Heather J. ,   WAO Pediatric Asthma Committee
Published: April 2024

AbstractMonitoring is a major component of asthma management in children. Regular monitoring allows for diagnosis confirmation, treatment optimization, and natural history review. Numerous factors that may affect disease activity and patient well‐being need to be monitored: response and adherence to treatment, disease control, disease progression, comorbidities, quality of life, medication side‐effects, allergen and irritant exposures, diet and more. However, the prioritization of such factors and the selection of relevant assessment tools is an unmet need. Furthermore, rapidly developing technologies promise new opportunities for closer, or even “real‐time,” monitoring between visits. Following an approach that included needs assessment, evidence appraisal, and Delphi consensus, the PeARL Think Tank, in collaboration with major international professional and patient organizations, has developed a set of 24 recommendations on pediatric asthma monitoring, to support healthcare professionals in decision‐making and care pathway design.
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The transition from diet to blood: Exploring homeostasis in the insect haemolymph nutrient pool
Authors: Holdbrook Robert , Andongma Awawing A. , Randall Joanna L. , Reavey Catherine E. , Tummala Yamini , Wright Geraldine A. , Simpson Stephen J. , Smith Judith A. , Wilson Kenneth , Cotter Sheena C. 
Published: April 2024

AbstractNutrition is vital to health, but while the link between diet and body nutritional composition is well explored in humans and other vertebrates, this information is not well understood in insects, despite the vital roles they play in ecosystems, and their increasing use as experimental models. Here we used Nutritional Geometry to explore the rapid physiological response to ingested nutrients in the haemolymph nutritional profile of Spodoptera littoralis caterpillars. We ask whether blood nutrients are maintained homeostatically in the face of variable nutritional intake, or if regulation is more flexible for some nutrients than others (allostasis), which allows animals to adapt to stress by responding in a way that prioritises efficiency of responses in the face of trade‐offs. Caterpillars were placed on 1 of 20 diets, systematically varying in their nutrient ratios (protein: carbohydrate) and density (calorie content), and their consumption was measured. After 48 h, caterpillars were bled, and the macronutrient (protein, carbohydrates and lipids) and nutrient metabolite (amino acids and simple sugars) content of the haemolymph was measured. Proteins comprised 93% of the haemolymph macronutrient pool on average and their concentration increased with protein eaten. The amino acid (AA) pool was dominated by five AAs, and the total pool increased with total nutrient intake. However, the ratio of essential to non‐essential AAs increased as the proportion of protein consumed increased. Carbohydrates were tightly controlled, increasing only on the most extreme carbohydrate intakes. Simple sugars were dominated by glucose and trehalose, and overall, the simple sugar pool showed high levels of homeostasis. Rather than strict homeostasis of blood nutritional properties, an allostatic model seemed to be a better fit for blood nutrient regulation in this generalist herbivore. This flexibility in response to the nutritional composition of the diet may, in part, explain how this species has evolved to extreme dietary generalism and may play a role in its worldwide pest status. Given the range of fitness‐related processes affected by the haemolymph, future studies should examine the physiological impacts of blood nutrient variation on reproduction, growth and response to infection and the trade‐offs between them.