bluuebunny/crossref_metadata_2025_split huggingface dataset:
Numerical simulation of hybrid nanofluid flow consisting of polymer–CNT matrix nanocomposites subject to Lorentz force and heat source/sink across coaxial cylinders
Authors: Ali Bilal , Jubair Sidra , Siddiqui Md Irfanul Haque 
Published: May 2024

The hybrid nanofluid (HNF) flow consists of polymer/CNT matrix nanocomposite material (MNC) across coaxial cylinders is numerically described in this study. The HNF flow is inspected under the consequences of thermal radiation, exponential heat source/sink and viscous dissipation. The HNF is prepared by adding polymer/CNT MNC in water. MNCs are highly productive elements with unique designs and properties. The MNCs are widely used in biomedicine and electrical applications due to their exceptional thermophysical properties. Based on their exceptionally high electrical conductivity, CNT/polymer nanoparticles (NPs) are also utilized as shielding for electrostatic discharge and electromagnetic interference (EMI). The HNF flow is modeled with the help of energy, continuity, and momentum equations. MATLAB package bvp4c is used to numerically handle the modeled equations. It has been perceived that the intensifying numbers of polymer/CNT MNC will lessen the fluid velocity and temperature profile in cases of both nanofluid and HNF.
Tangent hyperbolic nanofluid flow through a vertical cone: Unraveling thermal conductivity and Darcy–Forchheimer effects
Authors: Khan Ambreen Afsar , Zafar Saliha , Khan Aziz , Abdeljawad Thabet 
Published: May 2024

Purpose: This paper demonstrates the way tangent hyperbolic nanofluid flow through a vertical cone is influenced by varying viscosity and varying thermal conductivity. This study also seeks to illustrate the impact of convective boundary conditions on a fluid. The mathematical modeling also takes the Darcy–Forchheimer effect into account. Methodology: Using the appropriate similarity transformation, the fluid problem is reduced into a set of nonlinear ordinary differential equations. These systems of differential equations are evaluated numerically by applying the Optimal Homotopy Asymptotic Method. Findings: The nature of emergent parameters is examined in relation to the temperature distribution, nanoparticle concentration profile, and velocity profile. An increase in variable viscosity corresponds to a decrease in fluid velocity, while enhanced thermal conductivity results in elevated fluid temperature. The skin friction coefficient, Sherwood, and Nusselt numbers are numerically examined for active concerned parameters. These findings can be put into practice in a variety of fields such as polymer cooling systems and medication. Originality: Existing literature has yet to explore the combination of tangent hyperbolic nanofluids with varying viscosity and thermal conductivity under convective boundary conditions.
The Evolution of the Phase Space Structure Along Pitchfork and Period-Doubling Bifurcations in a 3D-Galactic Bar Potential
Authors: Moges H. T. , Katsanikas M. , Patsis P. A. , Hillebrand M. , Skokos Ch. 
Published: May 2024

We investigate how the phase space structure of a Three-Dimensional (3D) autonomous Hamiltonian system evolves across a series of successive Two-Dimensional (2D) and 3D pitchfork and period-doubling bifurcations, as the transition of the parent families of Periodic Orbits (POs) from stability to simple instability leads to the creation of new stable POs. Our research illustrates the consecutive alterations in the phase space structure near POs as the stability of the main family of POs changes. This process gives rise to new families of POs within the system, either maintaining the same or exhibiting higher multiplicity compared to their parent families. Tracking such a phase space transformation is challenging in a 3D system. By utilizing the color and rotation technique to visualize the Four-Dimensional (4D) Poincaré surfaces of section of the system, i.e. projecting them onto a 3D subspace and employing color to represent the fourth dimension, we can identify distinct structural patterns. Perturbations of parent and bifurcating stable POs result in the creation of tori characterized by a smooth color variation on their surface. Furthermore, perturbations of simple unstable parent POs beyond the bifurcation point, which lead to the birth of new stable families of POs, result in the formation of figure-8 structures of smooth color variations. These figure-8 formations surround well-shaped tori around the bifurcated stable POs, losing their well-defined forms for energies further away from the bifurcation point. We also observe that even slight perturbations of highly unstable POs create a cloud of mixed color points, which rapidly move away from the location of the PO. Our study introduces, for the first time, a systematic visualization of 4D surfaces of section within the vicinity of higher multiplicity POs. It elucidates how, in these cases, the coexistence of regular and chaotic orbits contributes to shaping the phase space landscape.
Development of Arduino-based high heat detector temperature control prototype for household appliances
Authors: Casinillo Rhoda Mae L. , So Allecia Leona A. , Mandaya Maezel V. , Dabalos Sonny Adrian J. , Enriquez Mark Ceasar S. , Cane Jas Felicisimo 
Published: May 2024

<span lang="EN-US">In the Philippines, fires are a widespread concern, with plenty of incidents attributed to electrical appliances. These incidents are a leading cause of non-open flame fires in the country, highlighting the urgent need for preventative measures. Existing devices could only trigger an alarm at 100 °C without shutting off the appliance automatically. To address these limitations, the researchers aimed to develop a high heat detector with 95% detection accuracy and less than 5% error in detecting high heat. This device used an Arduino Uno Board and relay to trigger an automated power-off mechanism in appliances experiencing high heat. Temperature changes were detected, and alarms were activated using an LM35 temperature sensor and buzzer. The accuracy of the LM35 sensor was assessed through hot bath tests, which included 12 trials at each temperature level between 80 °C and 150 °C with 10 °C intervals. The prototype’s performance revealed an average error rate of 1.13% and an average standard deviation of 0.9403. The computed F1 Score of 98% indicated that the prototype fulfilled the objectives. Functionality tests confirmed that the prototype successfully achieved its intended goal by shutting off the appliance when the threshold temperature was reached and enabling its operation otherwise.</span>
Distributed and autonomous multi-robot for task allocation and collaboration using a greedy algorithm and robot operating system platform
Authors: Tamali Abderrahmane , Amardjia Nourredine , Tamali Mohammed 
Published: May 2024

Research investigations in the realm of micro-robotics often center around strategies addressing the multi-robot task allocation (MRTA) problem. Our contribution delves into the collaborative dynamics of micro-robots deployed in targeted hostile environments. Employing advanced algorithms, these robots play a crucial role in enhancing and streamlining operations within sensitive areas. We adopt a tailored GREEDY approach, strategically adjusting weight parameters in a multi-objective function that serves as a cost metric. The objective function, designed for optimization purposes, aggregates the cost functions of all agents involved. Our evaluation meticulously examines the MRTA efficiency for each micro-robot, considering dependencies on factors such as radio connectivity, available energy, and the absolute and relative availability of agents. The central focus is on validating the positive trend associated with an increasing number of agents constituting the cluster. Our methodology introduces a trio of micro-robots, unveiling a flexible strategy aimed at detecting individuals at risk in demanding environments. Each micro-robot within the cluster is equipped with logic that ensures compatibility and cooperation, enabling them to effectively execute assigned missions. The implementation of MRTA-based collaboration algorithms serves as an adaptive strategy, optimizing agents' mobility based on specific criteria related to the characteristics of the target site.<p class="JAMRISAbstract"> </p>
Efficacy and safety of perioperative melatonin for postoperative delirium in patients undergoing surgery: a systematic review and meta-analysis
Authors: Shin Hye Won , Kwak Ji Su , Choi Yoon Ji , Kim Jae Woo , You Hae Sun , Shin Hyun Ju , Jang Yoo Kyung 
Published: May 2024

Objective To assess the efficacy and safety of perioperative melatonin and melatonin agonists in preventing postoperative delirium (POD). Methods We conducted a systematic search for randomized controlled trials (RCTs) published through December 2022. The primary outcome was efficacy based on the incidence of POD (POD-I). Secondary outcomes included efficacy and safety according to the length of hospital or intensive care unit stay, in-hospital mortality, and adverse events. Subgroup analyses of POD-I were based on the type and dose of drug (low- and high-dose melatonin, ramelteon), the postoperative period (early or late), and the type of surgery. Results In the analysis (16 RCTs, 1981 patients), POD-I was lower in the treatment group than in the control group (risk ratio [RR] = 0.57). POD-I was lower in the high-dose melatonin group than in the control group (RR = 0.41), whereas no benefit was observed in the low-dose melatonin and ramelteon groups. POD-I was lower in the melatonin group in the early postoperative period (RR = 0.35) and in patients undergoing cardiopulmonary surgery (RR = 0.54). Conclusion Perioperative melatonin or melatonin agonist treatment suppressed POD without severe adverse events, particularly at higher doses, during the early postoperative period, and after cardiopulmonary surgery.
Mapping dynamic molecular changes in hippocampal subregions after traumatic brain injury through spatial proteomics
Authors: Maity Sudipa , Huang Yuanyu , Kilgore Mitchell D. , Thurmon Abbigail N. , Vaasjo Lee O. , Galazo Maria J. , Xu Xiaojiang , Cao Jing , Wang Xiaoying , Ning Bo , Liu Ning , Fan Jia 
Published: May 2024

Abstract
Background
Traumatic brain injury (TBI) often results in diverse molecular responses, challenging traditional proteomic studies that measure average changes at tissue levels and fail to capture the complexity and heterogeneity of the affected tissues. Spatial proteomics offers a solution by providing insights into sub-region-specific alterations within tissues. This study focuses on the hippocampal sub-regions, analyzing proteomic expression profiles in mice at the acute (1 day) and subacute (7 days) phases of post-TBI to understand subregion-specific vulnerabilities and long-term consequences.

Methods
Three mice brains were collected from each group, including Sham, 1-day post-TBI and 7-day post-TBI. Hippocampal subregions were extracted using Laser Microdissection (LMD) and subsequently analyzed by label-free quantitative proteomics.

Results
The spatial analysis reveals region-specific protein abundance changes, highlighting the elevation of FN1, LGALS3BP, HP, and MUG-1 in the stratum moleculare (SM), suggesting potential immune cell enrichment post-TBI. Notably, established markers of chronic traumatic encephalopathy, IGHM and B2M, exhibit specific upregulation in the dentate gyrus bottom (DG2) independent of direct mechanical injury. Metabolic pathway analysis identifies disturbances in glucose and lipid metabolism, coupled with activated cholesterol synthesis pathways enriched in SM at 7-Day post-TBI and subsequently in deeper DG1 and DG2 suggesting a role in neurogenesis and the onset of recovery. Coordinated activation of neuroglia and microtubule dynamics in DG2 suggest recovery mechanisms in less affected regions. Cluster analysis revealed spatial variations post-TBI, indicative of dysregulated neuronal plasticity and neurogenesis and further predisposition to neurological disorders. TBI-induced protein upregulation (MUG-1, PZP, GFAP, TJP, STAT-1, and CD44) across hippocampal sub-regions indicates shared molecular responses and links to neurological disorders. Spatial variations were demonstrated by proteins dysregulated in both or either of the time-points exclusively in each subregion (ELAVL2, CLIC1 in PL, CD44 and MUG-1 in SM, and SHOC2, LGALS3 in DG).

Conclusions
Utilizing advanced spatial proteomics techniques, the study unveils the dynamic molecular responses in distinct hippocampal subregions post-TBI. It uncovers region-specific vulnerabilities and dysregulated neuronal processes, and potential recovery-related pathways that contribute to our understanding of TBI’s neurological consequences and provides valuable insights for biomarker discovery and therapeutic targets.
Safety of single-use flexible ureteroscopy for dusting of upper urinary tract calculi in children
Authors: Samir Ahmed , EL Gamal Osama , El Gamal Samir , Nagla Salah 
Published: May 2024

Abstract
Background
Flexible ureteroscopy offers numerous advantages, such as increased reach, superior stone-free rate, reduced risk of bleeding, minimal surgical trauma, and faster recovery time. There are few studies discussing the effectiveness of single-use flexible ureteroscopy in children, and none so far have addressed its safety. This study aims to evaluate the effectiveness and safety of a single-use flexible ureteroscope for treating upper urinary tract stones in children.

Methods
This study included children with single upper urinary tract stones measuring less than 2 cm who underwent single-use flexible ureteroscopy between October 2020 and January 2023. We assessed the following patient characteristics: age, gender, stone type, size, position, pre and postoperative stent placements, use of a ureteral access sheath, stone-free rate, operation duration, and the rate of complications. A patient was considered stone-free if there were no residual stone particles larger than 3 mm after surgery.

Results
Flexible ureteroscopy and holmium laser lithotripsy were undertaken for 44 participants, with an average age of 8.5 years (range: 2–16 years). The typical stone size was 14 mm (range: 6–20 mm). The average operation time was 74 min (range 35–110 min). Ureteral access sheaths were used in 81.8% (36 out of 44) of procedures. After a single FURS session, 86.36% (38 out of 44) of patients achieved stone-free status. Postoperative JJ stent application was noted in 86.4% (38 out of 44) of patients. Complications were categorized using the Calvien system, revealing that 25% (11 out of 44) of patients experienced mild hematuria, colic, and low-grade fever (Calvien I). No severe side effects like mucosal avulsion or ureteral perforation were reported.

Conclusion
In the short-term, single-use flexible ureteroscopy is a safe and effective method for managing single renal and proximal ureteric stones, measuring 2 cm or less, in children.
The practice and determinants of ambulance service utilization in pre-hospital settings, Jimma City, Ethiopia
Authors: Adem Mohammed Ahmed , Tezera Zewdu Baye , Agegnehu Chilot Desta 
Published: May 2024

Abstract
Background
In pre-hospital setting, ambulance provides emergency care and means of transport to arrive at appropriate health centers are as vital as in-hospital care, especially, in developing countries. Accordingly, Ethiopia has made several efforts to improve accessibility of ambulances services in prehospital care system that improves the quality of basic emergency care. Yet, being a recent phenomenon in Ethiopia, empirical studies are inadequate with regard to the practice and determinants of ambulance service utilization in pre-hospital settings. Hence, this study aimed to assess the ambulance service utilization and its determinants among patients admitted to the Emergency Departments (EDs) within the context of pre-hospital care system in public hospitals of Jimma City.

Method
A cross-sectional study design was used to capture quantitative data in the study area from June to July 2022. A systematic sampling technique was used to select 451 participants. Interviewer-administered questionnaire was used to collect data. Data analysis was done using SPSS version 26.0; descriptive and logistic regressions were done, where statistical significance was determined at p < 0.05.

Results
Ambulance service was rendered to bring about 39.5% (of total sample, 451) patients to hospitals. The distribution of service by severity of illnesses was 48.7% among high, and 39.4% among moderately acute cases. The major determinants of ambulance service utilization were: service time (with AOR, 0.35, 95%CI, 0.2-0.6 for those admitted to ED in the morning, and AOR, 2.36, 95%CI, 1.3-4.4 for those at night); referral source (with AOR, 0.2, 95%CI, 0.1-0.4 among the self-referrals); mental status (with AOR, 1.9, 95%CI, 1-3.5 where change in the level of consciousness is observed); first responder (AOR, 6.3 95%CI, 1.5-26 where first responders were the police, and AOR, 3.4, 95%C1, 1.7-6.6 in case of bystanders); distance to hospital (with AOR,0.37, 95%CI, 0.2-0.7 among the patients within ≤15km radius); and prior experience in ambulance use (with AOR, 4.1,95%CI, 2.4-7).

Conclusion
Although the utilization of ambulance in pre-hospital settings was, generally, good in Jimma City; lower levels of service use among patients in more acute health conditions is problematic. Community-based emergency care should be enhanced to improve the knowledge and use of ambulance services.
High expression of SRSF1 facilitates osteosarcoma progression and unveils its potential mechanisms
Authors: Li Shuqi , Huang Xinyi , Zheng Shuang , Zhang Wenhui , Liu Fang , Cao Qinghua 
Published: May 2024

Abstract
Background
SRSF1, a member of Serine/Arginine-Rich Splicing Factors (SRSFs), has been observed to significantly influence cancer progression. However, the precise role of SRSF1 in osteosarcoma (OS) remains unclear. This study aims to investigate the functions of SRSF1 and its underlying mechanism in OS.

Methods
SRSF1 expression level in OS was evaluated on the TCGA dataset, TAGET-OS database. qRT-PCR and Western blotting were employed to assess SRSF1 expression in human OS cell lines as well as the interfered ectopic expression states. The effect of SRSF1 on cell migration, invasion, proliferation, and apoptosis of OS cells were measured by transwell assay and flow cytometry. RNA sequence and bioinformatic analyses were conducted to elucidate the targeted genes, relevant biological pathways, and alternative splicing (AS) events regulated by SRSF1.

Results
SRSF1 expression was consistently upregulated in both OS samples and OS cell lines. Diminishing SRSF1 resulted in reduced proliferation, migration, and invasion and increased apoptosis in OS cells while overexpressing SRSF1 led to enhanced growth, migration, invasion, and decreased apoptosis. Mechanistically, Gene Ontology (GO) analysis, Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis, and Gene Set Enrichment Analysis (GSEA) revealed that the biological functions of SRSF1 were closely associated with the dysregulation of the protein targeting processes, location of the cytosolic ribosome, extracellular matrix (ECM), and proteinaceous extracellular matrix, along with the PI3K-AKT pathway, Wnt pathway, and HIPPO pathway. Transcriptome analysis identified AS events modulated by SRSF1, especially (Skipped Exon) SE events and (Mutually exclusive Exons) MXE events, revealing potential roles of targeted molecules in mRNA surveillance, RNA degradation, and RNA transport during OS development. qRT-PCR confirmed that SRSF1 knockdown resulted in the occurrence of alternative splicing of SRRM2, DMKN, and SCAT1 in OS.

Conclusions
Our results highlight the oncogenic role of high SRSF1 expression in promoting OS progression, and further explore the potential mechanisms of action. The significant involvement of SRSF1 in OS development suggests its potential utility as a therapeutic target in OS.
Simultaneous detection of dental caries and fissure sealant in intraoral photos by deep learning: a pilot study
Authors: Xiong Yanshan , Zhang Hongyuan , Zhou Shiyong , Lu Minhua , Huang Jiahui , Huang Qiangtai , Huang Bingsheng , Ding Jiangfeng 
Published: May 2024

Abstract
Background
Deep learning, as an artificial intelligence method has been proved to be powerful in analyzing images. The purpose of this study is to construct a deep learning-based model (ToothNet) for the simultaneous detection of dental caries and fissure sealants in intraoral photos.

Methods
A total of 1020 intraoral photos were collected from 762 volunteers. Teeth, caries and sealants were annotated by two endodontists using the LabelMe tool. ToothNet was developed by modifying the YOLOX framework for simultaneous detection of caries and fissure sealants. The area under curve (AUC) in the receiver operating characteristic curve (ROC) and free-response ROC (FROC) curves were used to evaluate model performance in the following aspects: (i) classification accuracy of detecting dental caries and fissure sealants from a photograph (image-level); and (ii) localization accuracy of the locations of predicted dental caries and fissure sealants (tooth-level). The performance of ToothNet and dentist with 1year of experience (1-year dentist) were compared at tooth-level and image-level using Wilcoxon test and DeLong test.

Results
At the image level, ToothNet achieved an AUC of 0.925 (95% CI, 0.880–0.958) for caries detection and 0.902 (95% CI, 0.853–0.940) for sealant detection. At the tooth level, with a confidence threshold of 0.5, the sensitivity, precision, and F1-score for caries detection were 0.807, 0.814, and 0.810, respectively. For fissure sealant detection, the values were 0.714, 0.750, and 0.731. Compared with ToothNet, the 1-year dentist had a lower F1 value (0.599, p < 0.0001) and AUC (0.749, p < 0.0001) in caries detection, and a lower F1 value (0.727, p = 0.023) and similar AUC (0.829, p = 0.154) in sealant detection.

Conclusions
The proposed deep learning model achieved multi-task simultaneous detection in intraoral photos and showed good performance in the detection of dental caries and fissure sealants. Compared with 1-year dentist, the model has advantages in caries detection and is equivalent in fissure sealants detection.