bluuebunny/crossref_metadata_2025_split huggingface dataset:
Asymmetries during Eyewall Replacement Cycles of Hurricane Ivan (2004)
Authors: Rojas Bruno S. , Didlake Anthony C. , Zhang Jun A. 
Published: May 2024

Abstract
The physical processes that govern eyewall replacement cycles (ERCs) in tropical cyclones (TCs) are not yet fully understood. In particular, asymmetric structures within the TC inner core have an uncertain role in ERC dynamics. This study analyzes the kinematic and precipitation asymmetric structures during successive ERCs in Hurricane Ivan (2004) using airborne Doppler radar observations. The azimuthal locations of these asymmetries are analyzed relative to the deep-layer (850–200 hPa) environmental wind shear vector. Two ERCs were analyzed at different stages of their evolution. During the concentric eyewall stage of the first ERC, the outer eyewall updrafts were strongest in the left-of-shear half, which also coincided with mesoscale descending inflow (MDI) just radially outward. Enhanced low-level convergence, updrafts, and MDI were collocated in a zone spiraling inward toward the strongest outer eyewall updrafts, suggesting that the vertical velocity asymmetry in the outer eyewall was possibly forced by a stratiform-induced cold pool similar to MDI impacts seen in past TC studies. During the final stage of the second ERC, the outer eyewall (now the singular primary eyewall) experienced an upwind shift in the precipitation and vertical velocity asymmetries. The updraft maximum shifted from the downshear-left quadrant to the downshear-right quadrant, and the precipitation maximum (downwind of the updraft maximum) shifted from left-of-shear to the downshear direction. This shift corroborates previous studies, which hypothesize that at the end of an ERC, the forcing mechanism that drives the eyewall vertical velocity asymmetry transitions from MDI/cold-pool processes to direct interaction with the environmental wind shear.
Patient perspectives on the unwanted effects of multidisciplinary pain management programmes: A qualitative study
Authors: Booth Gregory , Di Rosa Amanda , Corcoran Paula , Hallisey Charlotte , Lucas Andrew , Zarnegar Roxaneh 
Published: May 2024

Objective This study aimed to understand the impact of pain management programmes, focusing on the unwanted effects and their influence on patients’ long-term use of self-management strategies. Design Qualitative study. Setting Specialist musculoskeletal hospital in North London, England. Participants Patients with chronic musculoskeletal pain that have completed a pain management programme. Intervention Multidisciplinary pain management programmes. Main measures Data were collected regarding patients’ experiences and unwanted effects from the pain management programme using semi-structured interviews. Data were analysed using thematic analysis. Results Fourteen participant interviews were included in the analysis (median age 54 years, 12 females). Four themes were generated from the data: Benefits and burdens, Pain management programme and real life, Social support and Healthcare interventions. Unwanted effects included heightened anxiety related to negative interactions with peers, being in a new environment, worries about ability to cope with the programme, social anxiety from being in a group, the strain on families due to participants being away from home and a sense of abandonment at end of the programme. Burdens associated with implementing pain management strategies were identified, including the emotional burden of imposing their self-management on close family and competing demands with time and energy spent on self-management at the expense of work or home commitments. Conclusions Pain management programmes have an important role in helping patients to learn how to self-manage chronic pain. Their unwanted effects and the treatment burdens associated with long-term self-management may be an important consideration in improving the longevity of their beneficial effects.
Prognostic nomogram in middle-aged and elderly patients with chordoma: A SEER-based study
Authors: Ouyang Chenxi , Sun Yu , Li Yong , Jiang Ming , Nong Luming , Gao Gongming 
Published: May 2024

Background Chordoma is a bone tumor that tends to occur in middle-aged and elderly people. It grows relatively slowly but is aggressive. The prognosis of middle-aged and elderly patients with chordoma is quite different from that of young patients with chordoma. Objectives The purpose of the research was to construct a nomogram to predict the Individualized prognosis of middle-aged and elderly (age greater than or equal to 40 years) patients with chordoma. Methods In this study, we screened 658 patients diagnosed with chordoma from 1983 to 2015 in the Surveillance, Epidemiology, and End Results (SEER) database. We determined the independently prognostic factors that affect the survival of patients by univariate and multivariate Cox proportional hazards model. Based on the independent prognostic factors, we constructed a nomogram to predict the overall survival (OS) rates of middle-aged and elderly patients with chordoma at 3 and 5 years. The validation of this nomogram was completed by evaluating the calibration curve and the C-index. Results We screened a total of 658 patients and divided them into two cohort. Training cohort had 462 samples and validation cohort had 196 samples. The multivariate Cox proportional hazards model of the training group showed an association of age, tumor size, histology, primary site, surgery, and extent of disease with OS rates. Based on these results, we constructed the corresponding nomogram. The calibration curve and C-index showed the satisfactory ability of the nomogram in terms of predictive ability. Conclusion Nomogram can be an effective prognostic tool to assess the prognosis of middle-aged and elderly patients with chordoma and can help clinicians in medical decision-making and enable patients to receive more accurate and reasonable treatment.
Transitional Changes of Anxiety, Pain and Other Symptoms in Cancer Patients Admitted to a Palliative Care Unit, Evaluated Using the Support Team Assessment Schedule – Japanese Version
Authors: Ito Tetsuya , Tomizawa Emi , Yano Yuki , Akiyama Dai , Konishi Haruko , Takei Kiyozumi , Ikeda Masahiro , Takahashi Naoko , Shaku Fumio 
Published: May 2024

Objective: Association between physical symptoms and psychosocial difficulties of cancer patients has been reported widely. Nevertheless, the effects of pain and other symptom control on anxiety in such patients have not been investigated well. We investigated the association of improvement of pain and other symptoms with patient anxiety, and assessed factors associated with improvement of such symptoms. Methods: Data of patients with advanced cancer admitted to a palliative care unit during August 2018 – June 2022 were analyzed retrospectively. Severity of pain, other symptoms, and anxiety was assessed by the Support Team Assessment Schedule Japanese version (STAS-J) administered at admission and after 2 weeks. Patients’ physical data, their Palliative Prognostic Index (PPI) at admission, and their overall survival were collected and recorded. Results: Data of 701 patients were analyzed. Improvement of pain or other symptoms after 2 weeks was not associated with the PPI total score or actual survival ( P = .105 and .999). Patients with higher anxiety on admission experienced improvement of pain or other symptoms more frequently ( P = .005). Worsening of anxiety was observed less in patients who experienced improvement in pain or other symptoms after 2 weeks ( P = .027). Conclusion: Pain or other symptoms of patients with advanced cancer was improved irrespective of the general condition indicated with actual survival and prognosis-predictive factors. These findings suggest the importance of pain and other symptoms’ improvement and its important roles in the management of patient psychosocial problems such as anxiety.
Hsa_circ_0007482 Promotes Proliferation and Differentiation of Chondrocytes in Knee Osteoarthritis
Authors: Hou Dongjie , Lu Ling , Tao Ran 
Published: May 2024

Objective Knee osteoarthritis (KOA) is a complex degenerative joint disease and a major cause of joint dysfunction. This study aimed to explore the function of hsa_circ_0007482 on inflammation, proliferation, differentiation, and apoptosis in KOA. Design Real-time quantitative polymerase chain reaction (PCR) was performed to detect the expression of circ_0007482, inflammatory factors, and differentiation-related molecules in KOA chondrocytes and interleukin (IL)-1β–stimulated chondrocytes. The correlation between the circ_0007482 expression and inflammatory factors was analyzed by the Pearson method. KOA cell model was established using IL-1β for 24 hours. The proliferation activity of chondrocytes was evaluated by CCK-8 assay, and cell apoptosis rate was assessed by flow cytometry. The downstream miRNA of circ_0007482 was validated using dual-luciferase reporter assay. Results The circ_0007482 expression was elevated in both KOA cartilage tissues and IL-1β–treated chondrocytes and positively correlated with inflammatory factors expression. In comparison to the control group, IL-1β treatment diminished chondrocyte proliferation abilities and increased cell apoptosis and inflammatory factors IL-6, IL-8, and tumor necrosis factor (TNF)-α mRNA expression. Inhibition of circ_0007482 partially improved IL-1β–induced inflammatory reaction. Circ_0007482 could negatively regulate the expression of miR-558. Conclusions Interfering of circ_0007482 might partially promote cell proliferation and differentiation, while inhibit cell apoptosis to improve joint injury by regulating miR-558 in IL-1β–treated chondrocyte cell model.
Respiratory epithelial adenomatoid hamartoma: A rare differential diagnosis of sinonasal mass
Authors: Nefzaoui Safa , Zoghlami Imen , Gharsalli Jihene , Sabehi Emna , Romdhane Nadia , Helal Imen , Chiboub Dorra , Hariga Ines , Mbarek Chiraz 
Published: May 2024

Sino-nasal respiratory epithelial adenomatoid hamartomas (REAHs) are rare entity. They are benign tumors with excellent results after complete excision. We report a case of a 57-year-old male with a history of endoscopic surgery for right nasal polyps 20 years ago. The patient presented nasal obstruction that persisted for 10 years without anosmia nor epistaxis. Nasal endoscopy found a tissular mass filling the right nasal cavity extending to the nasopharynx. CT scan and MRI demonstrated soft tissue opacification of the right maxillary sinus and the homolateral anterior ethmoid cells with extension to the nasal cavity. The suspected diagnosis on imaging was an Inverted papilloma with a wide implantation base on the posterior part of the nasal septum. No endocranial or orbital extension was noted. The patient underwent endoscopic sinus surgery with complete extirpation of the tumor and a right ethmoidectomy. Histopathological assessment showed features consistent with REAH. No recurrence was noted at 1 year follow-up.
Gigantic laryngeal schwannoma: A case report with literature review
Authors: Nguyen Daniel , Htun Nyein Nyein , Johnson Cary 
Published: May 2024

Laryngeal schwannoma is a rare benign nerve sheath tumor that is slow growing. The diagnosis is made from a combination of clinical, radiological, and histopathological findings, and the main method of treatment is resection. We report a case of a 69-year-old presenting with a neck mass causing stridor, dysphagia, and orthopnea. CT of the neck showed an enhancing mass measuring 6.3 cm and extending superior to the larynx. Emergent tracheostomy and mass resection were performed, and histopathology and immunohistochemical findings were obtained from the specimen supporting schwannoma. In conclusion, while rare, schwannoma should always be considered as a differential diagnosis for a laryngeal mass. More studies are needed to assess the size and prognosis of the tumor.
Dataset size versus homogeneity: A machine learning study on pooling intervention data in e-mental health dropout predictions
Authors: Zantvoort Kirsten , Hentati Isacsson Nils , Funk Burkhardt , Kaldo Viktor 
Published: May 2024

Objective This study proposes a way of increasing dataset sizes for machine learning tasks in Internet-based Cognitive Behavioral Therapy through pooling interventions. To this end, it (1) examines similarities in user behavior and symptom data among online interventions for patients with depression, social anxiety, and panic disorder and (2) explores whether these similarities suffice to allow for pooling the data together, resulting in more training data when prediction intervention dropout. Methods A total of 6418 routine care patients from the Internet Psychiatry in Stockholm are analyzed using (1) clustering and (2) dropout prediction models. For the latter, prediction models trained on each individual intervention's data are compared to those trained on all three interventions pooled into one dataset. To investigate if results vary with dataset size, the prediction is repeated using small and medium dataset sizes. Results The clustering analysis identified three distinct groups that are almost equally spread across interventions and are instead characterized by different activity levels. In eight out of nine settings investigated, pooling the data improves prediction results compared to models trained on a single intervention dataset. It is further confirmed that models trained on small datasets are more likely to overestimate prediction results. Conclusion The study reveals similar patterns of patients with depression, social anxiety, and panic disorder regarding online activity and intervention dropout. As such, this work offers pooling different interventions’ data as a possible approach to counter the problem of small dataset sizes in psychological research.
Nuclear receptor Rev-erbα role in fine-tuning erythropoietin gene expression
Authors: Kumar Sumit , Arora Rashmi , Gupta Shalini , Ahuja Nancy , Bhagyaraj Ella , Nanduri Ravikanth , Kalra Rashi , Khare Asheesh Kumar , Kumawat Saumyata , Kaushal Vipashu , Sharma Mahathi , Gupta Pawan 
Published: May 2024

Abstract
The regulation of red blood cell (RBC) homeostasis by erythropoietin (EPO) is critical for O2 transport and maintaining the adequate number of RBCs in vertebrates. Therefore, dysregulation in EPO synthesis results in disease conditions such as polycythemia in the case of excessive EPO production and anemia, which occurs when EPO is inadequately produced. EPO plays a crucial role in treating anemic patients; however, its overproduction can increase blood viscosity, potentially leading to fatal heart failure. Consequently, the identification of druggable transcription factors and their associated ligands capable of regulating EPO offers a promising therapeutic approach to address EPO-related disorders. This study unveils a novel regulatory mechanism involving 2 pivotal nuclear receptors (NRs), Rev-ERBA (Rev-erbα, is a truncation of reverse c-erbAa) and RAR-related orphan receptor A (RORα), in the control of EPO gene expression. Rev-erbα acts as a cell-intrinsic negative regulator, playing a vital role in maintaining erythropoiesis at the correct level. It accomplishes this by directly binding to newly identified response elements within the human and mouse EPO gene promoter, thereby repressing EPO production. These findings are further supported by the discovery that a Rev-erbα agonist (SR9011) effectively suppresses hypoxia-induced EPO expression in mice. In contrast, RORα functions as a positive regulator of EPO gene expression, also binding to the same response elements in the promoter to induce EPO production. Finally, the results of this study revealed that the 2 NRs, Rev-erbα and RORα, influence EPO synthesis in a negative and positive manner, respectively, suggesting that the modulating activity of these 2 NRs could provide a method to target disorders linked with EPO dysregulation.
The role of Interleukin-22 in severe acute pancreatitis
Authors: Yang Hongli , Cao Ruofan , Zhou Feifei , Wang Ben , Xu Qianqian , Li Rui , Zhang ChunHua , Xu Hongwei 
Published: May 2024

AbstractSevere acute pancreatitis (SAP) begins with premature activation of enzymes, promoted by the immune system, triggering a potential systemic inflammatory response that leads to organ failure with increased mortality and a bleak prognosis. Interleukin-22 (IL-22) is a cytokine that may have a significant role in SAP. IL-22, a member of the IL-10 cytokine family, has garnered growing interest owing to its potential tissue-protective properties. Recently, emerging research has revealed its specific effects on pancreatic diseases, particularly SAP. This paper provides a review of the latest knowledge on the role of IL-22 and its viability as a therapeutic target in SAP.
Comparative whole-genome resequencing to uncover selection signatures linked to litter size in Hu Sheep and five other breeds
Authors: Zhong Tao , Hou Dunying , Zhao Qianjun , Zhan Siyuan , Wang Linjie , Li Li , Zhang Hongping , Zhao Wei , Yang Shizhong , Niu Lili 
Published: May 2024

AbstractHu sheep (HS), a breed of sheep carrying the FecB mutation gene, is known for its “year-round estrus and multiple births” and is an ideal model for studying the high fecundity mechanisms of livestock. Through analyzing and comparing the genomic selection features of Hu sheep and other sheep breeds, we identified a series of candidate genes that may play a role in Hu sheep’s high fecundity mechanisms. In this study, we conducted whole-genome resequencing on six breeds and screened key mutations significantly correlated with high reproductive traits in sheep. Notably, the CC2D1B gene was selected by the fixation index (FST) and the cross-population composite likelihood ratio (XP-CLR) methods in HS and other five breeds. It was worth noting that the CC2D1B gene in HS was different from that in other sheep breeds, and seven missense mutations have been identified. Furthermore, the linkage disequilibrium (LD) analysis revealed a strong linkage disequilibrium in this specific gene region. Subsequently, by performing different grouping based on FecB genotypes in Hu sheep, genome-wide selective signal analysis screened several genes related to reproduction, such as BMPR1B and PPM1K. Besides, FST analysis identified functional genes related to reproductive traits, including RHEB, HSPA2, PPP1CC, HVCN1, and CCDC63. Additionally, a missense mutation was found in the CCDC63 gene and the haplotype was different between the high reproduction (HR) group and low reproduction (LR) group in HS. In summary, we discovered genetic differentiation among six distinct breeding sheep breeds at the whole genome level. Additionally, we identified a set of genes which were associated with reproductive performance in Hu sheep and visualized how these genes differed in different breeds. These findings laid a theoretical foundation for understanding genetic mechanisms behind high prolific traits in sheep.
Morphological and biochemical variation of Ajuga chamaecistus Ging. ex Benth. in different habitats of Markazi province in the center of Iran
Authors: Mahmoodi Fatemeh , Bikdeloo Mahdi , Khadivi Ali , Akramian Morteza 
Published: May 2024

Abstract
Background
Medicinal plants, such as Ajuga chamaecistus Ging. ex Benth. are a natural and available source of treatment for a wide range of diseases. The objective of the present study was to assess the morphological and biochemical variation of 70 accessions of this species collected from seven geographical areas of Markazi province in the center of Iran.

Results
The measured traits exhibited considerable variability across the populations. Positive correlations were observed between antioxidant activity and total phenolic content, as well as total flavonoid content. Principal component analysis showed six components explaining 72.15% of the total variance, and the PC1 explained 20.68% of the total variance. The Ward dendrogram based on morphological variables identified two main clusters. Morphological analysis of A. chamaecistus showed a high variation between qualitative and quantitative traits that help the breeders for selecting the desired genotypes. The accessions collected from the Robat-Mil area showed the highest values for the recorded morphological characteristics. Also, the populations of Robat-Mil, Hassanabad, and Khaneh-Miran were characterized by high values of total phenolic content, total flavonoid content, and antioxidant activity, which can be used in various industries, including pharmaceuticals, cosmetics, and food.

Conclusions
Overall, the present results showed that the best place for the growth of A. chamaecistus with the production of significant contents of phenol and flavonoid is in Robat-Mil area.
Health mediation does not reduce the readmission rate of frequent users of emergency departments living in precarious conditions: what lessons can be learned from this randomised controlled trial?
Authors: Rotily Michel , Persico Nicolas , Lamouroux Aurore , Rojas-Vergara Ana Cristina , Loundou Anderson , Boucekine Mohamed , Apostolidis Themistoklis , Odena Sophie , Chischportich Celia , Auquier Pascal 
Published: May 2024

Abstract
Background
Severe overcrowding of emergency departments (EDs) affects the quality of healthcare. One factor of overcrowding is precariousness, but it has rarely been considered a key factor in designing interventions to improve ED care. Health mediation (HM) aims to facilitate access to rights, prevention, and care for the most vulnerable persons and to raise awareness among healthcare providers about obstacles in accessing healthcare. The primary aim was to determine whether HM intervention for frequent users of EDs (FUED) living in precarious conditions could reduce the readmission rate at 90 days.

Methods
Between February 2019 and May 2022, we enrolled and interviewed 726 FUED in four EDs of southeastern France in this randomised controlled trial. The HM intervention started in the ED and lasted 90 days. In addition to the primary endpoint (first readmission at 90 days), secondary endpoints (readmission at 30 and 180 days, number of hospitalisations at 30, 90, 180 days, admissions for the same reasons as the first admission) were also studied. The outcomes were measured in the ED information systems. Statistical methods included an intention-to-treat analysis and a per-protocol analysis. Comparisons were adjusted for gender, age, ED, and health mediator.

Results
46% of patients reported attending the ED because they felt their life was in danger, and 42% had been referred to the ED by the emergency medical dispatch centre or their GP; 40% of patients were considered to be in a serious condition by ED physicians. The proportion of patients who were readmitted at 90 days was high but did not differ between the control and the HM intervention groups (31.7% vs. 36.3%, p = 0.23). There was no significant difference in any of the secondary outcome measures between the control and HM intervention groups. Per-protocol analysis also showed no significant difference for the primary and secondary endpoints.

Conclusions
This randomised controlled trial did not show that our health mediation intervention was effective in reducing the use of emergency services by FUED living in precarious conditions. Some limitations are discussed: the duration of the intervention (90 days), the long-term effects (> 6 months), the involvement of the ED staff.

Trial registration
Registered on clinicaltrials.gov as NCT03660215 on 4th September 2018.