bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mitochondrial DNA mutations in disease and aging
Authors: Wallace Douglas C. 
Published: May 2010

AbstractThe human mitochondrial genome involves over 1,000 genes, dispersed across the maternally inherited mitochondrial DNA (mtDNA) and the biparentally inherited nuclear DNA (nDNA). The mtDNA encodes 13 core proteins that determine the efficiency of the mitochondrial energy‐generating system, oxidative phosphorylation (OXPHOS), plus the RNA genes for their translation within the mitochondrion. The mtDNA has a very high mutation rate, which results in three classes of clinically relevant mtDNA mutations: recently deleterious germline line mutations resulting in mitochondrial disease; ancient regional variants, a subset of which permitted humans to adapt to differences in their energetic environments; and somatic mutations that accumulate with age eroding mitochondrial energy production and providing the aging clock. Mutations in nDNA‐encoded OXPHOS structural genes can also cause mitochondrial disease, and alterations in nDNA mitochondrial biogenesis genes can destabilize the mtDNA and lead to clinical phenotypes. Finally, when combined, nonpathogenic nDNA and mtDNA protein variants can be functionally incompatible and cause disease. The essential functions of the conserved mtDNA proteins and their high mutation rate raise the question as to why the cumulative mtDNA genetic load does not result in species extinction. Studies of mice harboring deleterious mtDNA mutations have shown that the mammalian ovary selectively eliminates the most deleterious mtDNA mutations. However, milder mtDNA mutations are transmitted through the ovary and the female germline and introduced into the general population. This unique genetic system provides a flexible method for generating genetic variation in cellular and organismal energetics that permits species to adapt to alterations in their regional energetic environment. Environ. Mol. Mutagen. 2010. © 2010 Wiley‐Liss, Inc.
Multiple remote sensing techniques as a tool for reconstructing late Quaternary drainage in the Amazon lowland
Authors: Rossetti Dilce de Fátima 
Published: May 2010

AbstractMorphologies related to paleochannels are widespread through large areas of the Brazilian Amazonia. Despite the relevance for reconstructing the evolution of the largest fluvial system on Earth, detailed mapping of most of these features is still unavailable. The lack of works emphasizing Amazonian paleochannels represents an enormous bias toward the understanding of both migrating dynamics of Amazonian rivers through time and processes (e.g. tectonics, climate, sea‐level fluctuation) that might have promoted channel abandonment. A few previous studies have demonstrated the successful application of digital elevation model (DEM) collected during the Shuttle Radar Topography Mission (SRTM) for mapping morphologies related to paleochannels still preserved under forested lowland Amazonian areas. The present study applies different remote sensing techniques, including JERS‐1 90m, SAR/SIPAM‐6m, Landsat, and ASTER, to successfully unravel a myriad of paleochannels in Marajó Island (Amazon mouth), which were previously undetected using solely SRTM data. The results presented in this work are promising for mapping paleodrainage in other forested areas of the Amazonas basin. Considering the several problems involved on data acquisition aiming to approach the evolution of Amazonian rivers in space and time (e.g. large dimension, lack of natural geological exposures, difficult access, dense forest cover, and high cloud volume), a proper mapping of Amazonas paleodrainage using different remote sensing techniques is crucial to visualize potential paleochannel morphologies and patterns that are of high relevance for reconstructing the Amazonian fluvial dynamics through time. Copyright © 2010 John Wiley & Sons, Ltd.
Effect of reservoir construction on suspended sediment load in a large river system: thresholds and complex response
Authors: Xu Jiongxin , Yan Yunxia 
Published: May 2010

AbstractDam construction greatly alters the channel boundary of rivers, making the dammed river system a human‐controlled system. Based on hydrometric data in the upper Changjiang River basin, the change in behaviour of sediment transport of some dammed rivers was studied. As a result, some phenomena of threshold and complex response were found. When the coefficient (Cr,a) of actual runoff regulation by reservoirs, defined as the ratio of total capacity of reservoirs to annual runoff input, is smaller than 10%, suspended sediment load at Yichang station, the control station of the Changjiang River, shows a mild decreasing trend. When this coefficient becomes larger than 10%, suspended sediment load decreases sharply. The coefficient of 10% can be regarded as a threshold. The Cr,a of 10% is also a threshold, when the variation of suspended sediment concentration (SSC) with Cr,a at Yichang station is considered. The impacts of reservoir construction can be divided into several stages, including road construction, dam building and closure, water storage and sediment trapping. During these stages, some complex response was identified. At the station below the dam, SSC increases and reaches a maximum, and then declines sharply. This phenomenon was found on the main‐stem and several major tributaries of the upper Changjiang River. In the Minjiang River, where a series of dams were built successively, the response of SSC is more complicated. Copyright © 2010 John Wiley & Sons, Ltd.
Infiltration processes and flow rates in developed karst vadose zone using tracers in cave drips
Authors: Arbel Youval , Greenbaum Noam , Lange Jens , Inbar Moshe 
Published: May 2010

AbstractThe purpose of this research was to identify groundwater recharge mechanisms and measure flow velocities through the epikarst and the vadose zone in a typical site of Mediterranean carbonate karst in natural rain conditions. By avoiding artificial flushing more realistic travel times could be measured, and the effective resultant vadose flow velocity could be inferred. Additionally, detailed monitoring enabled better description and quantification of infiltration and percolation processes.Nine different cave drips were monitored and sampled for three hydrological years in fractured karst lithology on Mount Carmel, Israel. At three drips, discharge was measured continuously by tipping buckets. Rainfall and soil water content were recorded above the cave. An artificial tracer experiment was conducted using uranine placed in a joint and at the soil–rock interface at soil pockets, both 27 m above the cave.Four hydrological types of drips: post‐storm, seasonal, perennial, and overflow, were identified; each demonstrating different characteristics in terms of discharge and chemistry.The maximum effective flow velocities (uranine dye arrival times) were 41–76 cm/h; tracer mass flux was computed from the uranine breakthrough curves and drip hydrographs. The dominant flow velocities, derived from the peak of tracer mass flux, were 0·35–0·41 cm/h from post‐storm drips, and 22–24 cm/h from the other drips.‘Pulse‐through’ (intra‐event piston flow) was indicated by the time lags between the increase in drip rate and the time of drop in salinity and appearance of the tracer in most of the measured drips. Chloride concentrations were used to distinguish between ‘old/matrix water’ and ‘preferential‐flow water’ in the perennial drips, demonstrating a two‐component mixing model. In 2005–2006 ‘preferential‐flow water’ reached up to 20–25% from annual discharge of these drips. This study promoted a method to compute dominant effective flow rates in the vadose zone in natural rain conditions. Copyright © 2010 John Wiley & Sons, Ltd.
Toxic trace element assessment for soils/sediments deposited during Hurricanes Katrina and Rita from southern Louisiana, USA: A sequential extraction analysis
Authors: Shi Honglan , Witt Emitt C. , Shu Shi , Su Tingzhi , Wang Jianmin , Adams Craig 
Published: May 2010

Abstract
Analysis of soil/sediment samples collected in the southern Louisiana, USA, region three weeks after Hurricanes Katrina and Rita passed was performed using sequential extraction procedures to determine the origin, mode of occurrence, biological availabil ity, mobilization, and transport of trace elements in the environment. Five fractions: exchangeable, bound to carbonates, bound to iron (Fe)–manganese (Mn) oxides, bound to organic matter, and residual, were subsequently extracted. The toxic trace elements Pb, As, V, Cr, Cu, and Cd were analyzed in each fraction, together with Fe in 51 soil/sediment samples. Results indicated that Pb and As were at relatively high concentrations in many of the soil/sediment samples. Because the forms in which Pb and As are present tend to be highly mobile under naturally occurring environmental conditions, these two compounds pose an increased health concern.Vanadium and Cr were mostly associated with the crystal line nonmobile residual fraction. A large portion of the Cu was associated with organic matter and residual fraction. Cadmium concentrations were low in all soil/sediment samples analyzed and most of this element tended to be associated with the mobile fractions. An average of 21% of the Fe was found in the Fe–Mn oxide fraction, indicating that a substantial part of the Fe was in an oxidized form. The significance of the overall finding of the present study indicated that the high concentrations and high availabilities of the potentially toxic trace elements As and Pb may impact the environment and human health in southern Louisiana and, in particular, the New Orleans area. Environ. Toxicol. Chem. 2010;29:1419–1428. © 2010 SETAC
Performance of truncated hybrid ARQ schemes with noisy feedback for DS‐CDMA systems
Authors: Boujemâa H. 
Published: May 2010

AbstractIn this paper, we evaluate the theoretical expressions of the average coding rate, the probability of undetected errors and the probability of packet erasure (PE) of truncated Hybrid ARQ schemes with packet and code combining (CC) for direct sequence code division multiple access (DS‐CDMA) downlink systems using a Rake receiver. The different user packets are code multiplexed using a set of orthogonal variable spreading factor (OVSF) sequences. The analysis is carried in two extreme scenarios, with either a constant or a packet‐by‐packet independent multipath channel during the different transmissions. The obtained results are valid for any multipath intensity profile of the channel and take simultaneously into account additive white gaussian noise (AWGN), path gains estimation noise, intersymbol interference (ISI) and the multiuser interference (MUI). Copyright © 2010 John Wiley & Sons, Ltd.
Flammability of thermoplastic carbon nanofiber nanocomposites
Authors: Morgan Alexander B. , Liu Weidong 
Published: May 2010

AbstractFive commodity thermoplastics (polyethylene, polypropylene, thermoplastic polyurethane, poly(butylene terephthalate), and poly(amide 6)) were melt compounded with vapor grown carbon nanofibers via twin screw extrusion. These materials were then analyzed for flammability behavior by cone calorimeter to determine how the nanofibers would reduce flammability of the polymers. It was found by cone calorimeter that the nanofibers greatly reduced peak heat release rate and improved many other flammability parameters of the samples. However, smoke release was increased in all samples, which may be one drawback of using these materials. Interestingly, the amount of flammability reduction was not uniform across all samples, with nanofiber reducing flammability the most in the thermoplastic polyurethane sample. The mechanism of flammability reduction in the polymers tested in this paper is shown again to be a mass loss rate reduction induced by the formation of thick tangled networks of carbon nanofibers during polymer decomposition. This mechanism was confirmed by studying the mass loss rate curves and electron microscopy analysis of the final chars collected from the cone calorimeter experiments. Copyright © 2010 John Wiley & Sons, Ltd.
An evaluation of the impact of exemptions to the children's sleepwear flammability standards on burn injuries to children
Authors: Adair Patricia K. , Rodgers Gregory B. 
Published: May 2010

AbstractIn 1996, the U.S. Consumer Product Safety Commission (CPSC) amended the children's sleepwear flammability standards to exempt sleepwear sized for infants aged nine months or younger and tight‐fitting sleepwear for older children. The amendments were developed in response to an apparent preference for untreated cotton garments by many parents and difficulties in enforcing the pre‐amendment standards. However, they were adopted only after CPSC concluded that they would provide consumers a wider selection of children's sleepwear without diminishing the protection provided by the pre‐amendment standards. The amendments became effective in 1997, but remained controversial, with some interested parties believing that the exemptions would substantially reduce the level of safety for children. To address these concerns, and in cooperation with the American Burn Association and Shriners Hospitals for Children, the CPSC initiated a national study of child clothing‐related burn injuries treated in burn center hospitals. From 2003 through 2005, the CPSC collected information on 475 such injuries. This study evaluates the burn center data to help determine the safety effects of the amendments to the sleepwear standards. The results provide no evidence of increased risk of burn injury associated with the exemptions from the sleepwear standards. Copyright © 2010 John Wiley & Sons, Ltd.
Evidence for retrochiasmatic tissue loss in Leber's hereditary optic neuropathy
Authors: Barcella Valeria , Rocca Maria A. , Bianchi‐Marzoli Stefania , Milesi Jacopo , Melzi Lisa , Falini Andrea , Pierro Luisa , Filippi Massimo 
Published: May 2010

AbstractPatients with Leber's hereditary optic neuropathy (LHON) have loss of central vision with severe damage of small‐caliber fibers of the papillomacular bundle and optic nerve atrophy. The aim of this study was to define the presence and topographical distribution of brain grey matter (GM) and white matter (WM) injury in LHON patients using voxel‐based morphometry (VBM). The correlation of such changes with neuro‐ophthalmologic findings and measurements of peripapillary retinal nerve fiber layer (RNFL) thickness by optical coherence tomography (OCT) was also assessed. Dual‐echo and fast‐field echo scans were acquired from 12 LHON patients and 12 matched controls. VBM analysis was performed using SPM5 and an ANCOVA model. A complete neuro‐ophthalmologic examination, including standardized automated Humphrey perimetry as well as average and temporal peripapillary RNFL thickness measurements were obtained in all the patients. Compared with controls, average peripapillary RNFL thickness was significantly decreased in LHON patients. LHON patients also had significant reduced GM volume in the bilateral primary visual cortex, and reduced WM volume in the optic chiasm, optic tract, and several areas located in the optic radiations (OR), bilaterally. Visual cortex and OR atrophy were significantly correlated with average and temporal peripapillary RNFL thickness (P < 0.001; r values ranging from 0.76 to 0.89). Brain damage in patients with LHON is not limited to the anterior visual pathways, but extends posteriorly to the OR and the primary visual cortex. Such a damage to the posterior parts of the visual pathways may be due either to trans‐synaptic degeneration secondary to neuroaxonal damage in the retina and optic nerve or to local mitochondrial dysfunction. Hum Brain Mapp, 2010. © 2010 Wiley‐Liss, Inc.
A functional dissociation of conflict processing within anterior cingulate cortex
Authors: Kim Chobok , Kroger James K. , Kim Jeounghoon 
Published: May 2010

AbstractGoal‐directed behavior requires cognitive control to regulate the occurrence of conflict. The dorsal anterior cingulate cortex (dACC) has been suggested in detecting response conflict during various conflict tasks. Recent findings, however, have indicated not only that two distinct subregions of dACC are involved in conflict processing but also that the conflict occurs at both perceptual and response levels. In this study, we sought to examine whether perceptual and response conflicts are functionally dissociated in dACC. Thirteen healthy subjects performed a version of the Stroop task during functional magnetic resonance imaging (fMRI) scanning. We identified a functional dissociation of the caudal dACC (cdACC) and the rostral dACC (rdACC) in their responses to different sources of conflict. The cdACC was selectively engaged in perceptual conflict whereas the rdACC was more active in response conflict. Further, the dorsolateral prefrontal cortex (DLPFC) was coactivated not with cdACC but with rdACC. We suggest that cdACC plays an important role in regulative processing of perceptual conflict whereas rdACC is involved in detecting response conflict. Hum Brain Mapp, 2011. © 2010 Wiley‐Liss, Inc.
The map is not the territory: Motor system reorganization in upper limb amputees
Authors: Gagné Martin , Hétu Sébastien , Reilly Karen T. , Mercier Catherine 
Published: May 2010

AbstractIt is generally considered that hand amputation changes primary motor cortex (M1) stump muscle representations. Transcranial magnetic stimulation (TMS) studies show that the corticospinal excitability of a stump muscle and its homologous muscle on the intact side is not equivalent, and that the resting level of excitability is higher in the stump muscle. Since changes in M1 stump muscle map characteristics (e.g., size and location) are identified by comparing stump and intact muscle maps, such changes might reflect between‐side differences in corticospinal excitability rather than a true reorganization of the stump muscle's map. In eight above‐elbow amputees we used TMS to map the M1 representation of a stump muscle and its homologous muscle on the intact side during rest and contraction. Importantly, the same relative stimulation intensity was used to construct each map; stimulation was performed at 120% of the motor threshold of each muscle (intact/amputated limb) measured in each condition (rest/active contraction). Resting motor threshold was lower in the stump muscle, but active motor thresholds did not differ. Motor‐evoked potential amplitudes increased between the rest and muscle contraction conditions, but this increase was smaller for the stump muscle because its at‐rest corticospinal excitability was higher than that of the intact muscle. When the between‐side difference in excitability was considered no interhemispheric difference was found for map areas or for their medio‐lateral locations. The present results challenge the view that after an upper limb amputation the stump representation moves laterally and occupies a larger M1 territory. Hum Brain Mapp, 2011. © 2010 Wiley‐Liss, Inc.
The differentiation of iconic and metaphoric gestures: Common and unique integration processes
Authors: Straube Benjamin , Green Antonia , Bromberger Bianca , Kircher Tilo 
Published: May 2010

AbstractRecent research on the neural integration of speech and gesture has examined either gesture in the context of concrete [iconic (IC) gestures] or abstract sentence content [metaphoric (MP) gestures]. However, there has not yet been a direct comparison of the processing of both gesture types. This study tested the theory that left posterior temporal and inferior frontal brain regions are each uniquely involved in the integration of IC and MP gestures. During fMRI‐data acquisition, participants were shown videos of an actor performing IC and MP gestures and associated sentences. An isolated gesture (G) and isolated sentence condition (S) were included to separate unimodal from bimodal effects at the neural level. During IC conditions, we found increased activity in the left posterior middle temporal gyrus and its right hemispheric homologue. The same regions in addition to the left inferior frontal gyrus (IFG) were activated during MP conditions in contrast to the isolated conditions (G&S). These findings support the hypothesis that there are distinct integration processes for IC and MP gestures. In line with recent claims of the semantic unification theory, there seems to be a division between perceptual‐matching processes within the posterior temporal lobe and higher‐order relational processes within the IFG. Hum Brain Mapp, 2011. © 2010 Wiley‐Liss, Inc.
Abnormal white matter integrity in young children with autism
Authors: Weinstein Maya , Ben‐Sira Liat , Levy Yonata , Zachor Ditza A. , Itzhak Esti Ben , Artzi Moran , Tarrasch Ricardo , Eksteine Perla M. , Hendler Talma , Bashat Dafna Ben 
Published: May 2010

AbstractThis study investigated white matter integrity in young children with autism using diffusion tensor imaging (DTI). Twenty‐two children with autism, mean age 3:2 years, and 32 controls, mean age 3:4 years, participated in the study. Tract‐based spatial statistics (TBSS) revealed white matter abnormalities in several distinct clusters within the genu and body of the corpus callosum (CC), left superior longitudinal fasciculus (SLF) and right and left cingulum (Cg). TBSS–VOIs analysis was performed in the clusters where differences in fractional anisotropy (FA) were detected to investigate the relationship between changes in FA and diffusivity indices. In all VOIs, increase in FA was caused by a decrease in radial diffusivity (Dr), while no changes in axial diffusivity (Da) or mean diffusivity (MD) were observed. Tractography analysis was applied to further study the CC, SLF, and Cg. Witelson parcellation scheme was used for the CC. Significant increase in FA was seen in children with autism in the mid‐body of the CC as well as in the left Cg. It is suggested that such abnormal white matter integrity in young children with autism may adversely affect connectivity between different brain regions and may be linked to some of the behavioral impairments apparent in autism. Hum Brain Mapp, 2011. © 2010 Wiley‐Liss, Inc.
Diastereoselective synthesis of chloro‐ and fluoro‐aniline containing phosphonate esters in a three‐component condensation
Authors: Maghsoodlou Malek Taher , Hazeri Nourallah , Habibi‐Khorassani Sayyed Mostafa , Marandi Ghasem , Saghatforoush Lotfali , Saravani Danial , Torbati Niloufar Akbarzadeh , Rostami‐Charati Faramarz , Khandan‐Barani Khatereh , Skelton Brian W. , Makha Mohamed 
Published: May 2010

AbstractNew phosphonate ester derivatives were obtained by in situ stereo‐specific reaction between triphenyl phosphite and dialkyl acetylenedicarboxylates in the presence of a series of halogenated anilines. Spectroscopic data and X‐ray crystallography analysis are in agreement with the gauche arrangement for the two vicinal protons in the structures. © 2010 Wiley Periodicals, Inc. Heteroatom Chem 21:222–227, 2010; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/hc.20600