bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical Evaluation of Maharasnadi Kvatha, Trayodashanga Guggulu, and Brihatsaindhavadya Taila in the management of knee osteoarthritis (Janugata Sandhivata): An open-label single-arm clinical study
Authors: Sharma Bhuvnesh Kumar , Kumawat Vinod Bihari , Indu PP , Jain Avinash Kumar , Singh Krishna Kumar , Mata Sunita , Sharma Ramavtar , Tripathi Arunabh , Sharma Bhagwan Sahai , Khanduri Shruti , Bharathi K , Srikanth Narayanam , Dhiman Vaidya KS 
Published: June 2024

Abstract

INTRODUCTION:
Osteoarthritis (OA) is the foremost prevalent progressive musculoskeletal disorder characterized by the gradual and persistent degradation of cartilage tissue within joints due to bone friction. The risk factors associated with the development of OA include the female gender, advanced age (geriatric population), elevated body weight or obesity, and a history of a prior knee injury. Ayurveda therapy has great potential in the management of OA and its progression.

AIM:
This clinical study aims to assess the effect of selected Ayurveda formulations in the management of knee OA.

MATERIALS AND METHODS:
This was a prospective, single-center, open-label study carried out on 60 participants with primary OA of the knee. Inclusion criteria encompassed individuals aged between 35 and 65 years, meeting the diagnostic criteria outlined by the American College of Rheumatology, and with radiographic abnormalities characteristic of OA. Therapeutic interventions in the study comprised Maharasnadi Kvatha (MK) (50 mL twice a day in an empty stomach), Trayodashanga Guggulu (TG) (1500 mg twice daily), and Brihatsaindhavadya Taila (BST) (for local fomentation twice daily) for the duration of 84 days. The primary outcome of the study was change in the Indian Western Ontario and McMaster Universities arthritis index (WOMAC) score.

RESULTS:
Out of 60 participants, 58 subjects completed the study, while one subject dropped out and one was withdrawn. The analysis yielded statistically significant results (P < 0.001) in the Indian WOMAC (modified—clinical research data (CRD) Pune version) score and clinical symptoms and improvement in the quality of life (P < 0.001). X-ray assessments revealed the disappearance of osteophytes in knee joints in 8.62% of cases. A change in the mean pain score as assessed by the visual analog scale was also noticed with P < 0.001.

CONCLUSION:
The Ayurvedic interventions demonstrated significant effects in mitigating symptoms of knee OA, with no reported adverse events. This study substantiates the effectiveness of Ayurvedic management in alleviating symptoms of knee OA such as bony tenderness of joints, difficulty of physical function of knee joints, crepitus, and improvement in quality-of-life parameters.

CTRI REGISTRATION:
CTRI/2018/03/012292, dated 30-03-2020.
Commercial concession, license and franchise in the distribution model of network marketing
Authors: Филатов В.В. , Рамазанов И.А. , Полянская О.А. , Винокуров А.Ю. 
Published: June 2024

В статье проведен анализ применимости коммерческой концессии, лицензии и франшизы в дистрибьюторской модели сетевого маркетинга в современных социально-экономических условиях. Рассмотрены организационно-экономические и нормативно-правовые аспекты регулирования. Показано, что коммерческая концессия предусматривает использование комплекса особенных прав, профессиональной репутации и делового опыта правообладателя в определенном сторонами объеме и территории использования применительно к определенной области предпринимательской деятельности.
The article analyzes the applicability of commercial concession, license and franchise in the distribution model of network marketing in modern socio-economic conditions. The organizational, economic and regulatory aspects of regulation are considered. It is shown that a commercial concession provides for the use of a set of special rights, professional reputation and business experience of the rightholder in a certain volume and territory of use determined by the parties in relation to a certain area of entrepreneurial activity.
Savings of the population and the factors influencing them
Authors: Агеева Е.В. , Муфтохтдинова А.А. 
Published: June 2024

В статье анализируются сбережения населения. Отмечается, что сбережения являются ключевым фактором экономического развития любого государства, способствуют устойчивости экономики и экономическому росту. Домохозяйствам сбережения способны обеспечить финансовую стабильность и благополучие, становясь источником платежеспособности в период нужды или неопределенности.
The article analyzes the savings of the population. It is noted that savings are a key factor in the economic development of any state, contribute to the sustainability of the economy and economic growth. Savings can provide households with financial stability and well-being, becoming a source of solvency in times of need or uncertainty.
El derecho sucesorio de la mujer en el islam y sus divergencias con el derecho consuetudinario (al-ʿurf) y secular.
Authors: Ezzarhouni Amhaouch Fadoua 
Published: June 2024

Este trabajo presenta, por un lado, las nociones básicas del derecho de sucesiones en el islam y explica los conceptos más importantes relacionados con la herencia, el causante y la naturaleza de los legatarios, así como las categorías que ostentan los diferentes herederos, de las que depende la cuota con que concurren en la herencia, hecho que impacta de forma positiva en el género femenino al ostentar casi siempre la categoría de farḍ, garantizándole una cuota firme en contraposición de la cuota variable que recibe el género masculino. Por otro lado, ilustra algunas divergencias que resultan del contacto de este derecho sucesorio de inspiración religiosa con otros de naturaleza consuetudinaria o secular que afectan de manera desigual a las mujeres, por lo que este trabajo expone los problemas a los que se enfrentan las mujeres de credo musulmán para poder optar a la cuota que les es asignada por la šarīʿa, ya sea por los obstáculos que imponen las costumbres locales que intentan apartar a las mujeres y situar a los hombres frente a las propiedades familiares por diferentes razones y métodos para eludir la ley, o por su colisión con las leyes seculares en las cuales no hay cabida para ejercer su libertad religiosa.
O RETRATO DO SILENCIAMENTO DOS DIREITOS FUNDAMENTAIS DAS CRIANÇAS NO CONTEXTO EDUCACIONAL VISTO EM REPORTAGENS DO G1 DE MINAS GERAIS
Authors: Senra Magda Sousa , Ribeiro Josimar Gonçalves 
Published: June 2024

Este artigo tem por objetivo demonstrar como as crianças, enquanto atores sociais e sujeitos de direitos, são silenciadas e excluídas da participação ativa, assegurada pela Constituição Federal de 1988, por instituições direcionadas ao direito da criança. A metodologia consiste em uma abordagem quali-quantitativa, de objetivo descritivo e procedimento documental. No corpus, dezenove matérias de cunho educacional, que são oriundas de 93 reportagens sobre crianças extraídas do G1 de Minas Gerais entre janeiro e dezembro de 2021, analisadas conforme os preceitos de Bardin (2022). A conclusão evidencia a prática social de um processo de silenciamento e exclusão infligido sobre crianças e adolescentes nas questões em que eles são o alvo das ações da família dentro do campo educacional.
EFL Teachers’ Professional Identity: Insights and Experiences in FYP in a Saudi Context
Authors: Alhoussawi Hussain , Anwar Muhammad Mansoor 
Published: June 2024

There has been significant increase in research on exploring and understanding EFL teachers’ professional identities in various contexts. The EFL teachers play an important role in developing Saudi EFL learners’ English language skills to facilitate in their academic endeavors. The current study aimed to explore EFL teachers’ professional identity construction and negotiation process. Also, it intended to investigate how contextual factors influence this process. To this end, five experienced EFL teachers were chosen through purposive sampling from English Language Institute (ELI) teaching at a public-university in Saudi Arabia. The data were collected through in depth standardized open-ended interviews. The data were analyzed thematically (Braun & Clarke, 2006) by reading and reading the interview transcripts, and developing codes, categories and themes. The findings revealed that the participants found a few factors quite motivating for them to sustain their professional identity. However, there were many contextual factors that caused conflict in their construction and negotiations process of their identities and resulted in significantly contributed to their weaker professional identities. The findings can have pedagogical implications for EFL teachers, and they can prepare themselves better to deal with contextual dilemmas to perform better in the current settings. For policy makers, it can be implied that they can provide conducive environment to teachers for developing their strong professional identities.
Reliability of the HUMAC360 to Measure Movement Velocity during Three Equal Segments of the Barbell Back Squat
Authors: Edward Z. Pelka  , Jennifer Rivera  , Ryan W. Gant  , Anthony G. Pinzone  , Emily C. Tagesen  , Modesto A. Lebron  , Adam R. Jajtner  
Published: June 2024

Introduction: Linear position transducers (LPT) are commonly used to assess movement velocity during full concentric movements, but fail to account for fluctuations in velocity throughout the movement. This investigation aimed to determine inter-set and inter-day reliability of the HUMAC360 LPT during three equal segments of the barbell back squat.
Methods: Seventeen participants with resistance exercise experience completed an informed consent and a one-repetition maximum (1RM) on their initial visit, with two additional visits consisting of two sets of three repetitions at 30-, 50-, 60- and 70% of 1RM with ≥ 48H between visits. The LPT was attached to the medial aspect of the barbell sleeve to assess velocity. Repetitions were segmented into thirds based on distance as the top, middle and bottom portion of the movement. Intraclass Correlation Coefficients (ICC), standard error of the measurement and paired samples t-tests were used to assess mean velocity (MV), peak velocity (PV) and duration reliability.
Results: When using the average of the three repetitions, good-to-excellent (ICC2,1=0.708-0.993) inter-set and inter-day MV and PV ICCs were noted across all intensities and segments. The top and middle portion exhibited stronger reliability measures compared to the bottom. Movement velocity was not significantly different (p>0.05) at any exercise intensity, with the exception of MV at 60% during the top portion of the movement (p=0.045).
Conclusions: The HUMAC360 provides reliable measures of mean velocity and peak velocity during each segment of the barbel back squat.
Using Precipitation Forecasts to Irrigate Cotton
Authors: Christ Emily , Webster Peter , Collins Guy , Toma Violeta , Byrd Seth 
Published: June 2024

In this experiment, precipitation forecasts were used to schedule irrigation for cotton (Gossypium hirsutum L.). Four irrigation treatments and two cotton varieties were evaluated at Stripling Irrigation Research Park located near Camilla, GA in 2014. Two treatments were irrigated based on forecasts from the European Centre for Medium-Range Weather Forecasts (ECMWF) Ensemble Prediction System (EPS) and The Weather Channel®’s mobile app. Irrigation amounts for these two treatments were determined by the Cotton Irrigation Schedule Suggested for High Yields (check-book recommendations). The third treatment was irrigated by the check-book method and the fourth was rainfed. Irrigation applied for each treatment was 34.8 cm, 26.7cm, and 31.9 cm for the ECMWF EPS, weather.com, and check-book, respectively. Rainfed cotton received 16.56 cm in precipitation. All irrigation methods resulted in significantly higher yields than the rainfed cotton. Results suggest using precipitation forecasts to schedule irrigation could provide a convenient alternative to the check-book method.
CLINICAL CASE OF SEVERE BRONCHIAL ASTHMA IN CHILDHOOD: DIFFICULTIES IN DIAGNOSIS AND TREATMENT
Authors: Черненков Юрий Валентинович , Эйберман Александр Семенович , Воротникова Наталия Анатольевна 
Published: June 2024

Накопились новые данные, свидетельствующие о наличии патогенетически обоснованной взаимосвязи между бронхиальной астмой (БА), пневмонией и гастроэзофагеальной рефлюксной болезнью (ГЭРБ) у детей. Частые срыгивания и рвота сопровождаются развитием воспалительных процессов в пищеводе. Отсутствие разрешения патологического процесса в легких становится поводом для поиска причин затяжного течения болезни. У детей с сочетанным течением воспалительных изменений в легких и ГЭРБ антирефлюксные программы должны проводиться в течение ближайших двух недель после их развития для предотвращения обострения. При высокой частоте встречаемости ГЭРБ и наличия бронхиальной обструкции в алгоритм обследования сочетанной патологии необходимо включать эзофагогастродуоденоскопию, внутрипищеводную рН-метрию с последующей медикаментозной коррекцией. При сочетанном течении заболеваний органов дыхания и пищеварения лечение должно включать препараты, действие которых направлено как на купирование бронхообструктивного синдрома (БОС), так и на уменьшение клинических симптомов ГЭРБ. Приведенный клинический случай демонстрирует процесс постановки диагноза и эффективность комплексной терапии.
New data have accumulated indicating the presence of a pathogenetically substantiated relationship between bronchial asthma (BA), pneumonia and gastroesophageal refluxdisease (GERD) in children. Frequent regurgitation and vomiting are accompanied by the development of inflammatory processes in the esophagus. The lack of resolution of the pathologicalprocess in the lungs becomes the reason for the search for the causes of the protracted course of the disease. In children with a combined course of inflammatory changes in the lungs andGERD, antireflux programs should be carried out within the next two weeks after their development to prevent exacerbation. With a high frequency of occurrence of GERD and the presence ofbronchial obstruction, it is necessary to include esophagogastroduodenoscopy, intraesophageal pH-metry followed by medical correction in the algorithm for examining combined pathology.With the combined course of diseases of the respiratory and digestive organs, treatment should include drugs whose action is aimed at both relieving bronchial obstructive syndrome (BOS) andreducing the clinical symptoms of GERD. The above clinical case demonstrates the process of diagnosis and the effectiveness of complex therapy.
Contact Sensitivity of Turkish Children and Adolescents to European Baseline Series Allergens between 2013 and 2023
Authors: Kalay Yildizhan Incilay , Boyvat Ayse 
Published: June 2024

Introduction: Raising the numbers of patch testing in suspected children increases the rate of diagnosis of allergic contact dermatitis and the identification of clinically relevant allergens. Objective: The aim of this study to identify the most frequently observed allergens among Turkish children and adolescents patch tested in 2013-2023. Methods: The patch test results of 160 patients (age ≤18) were analyzed retrospectively. The frequency of contact allergens and distribution of positive results in terms of gender, age group (children and adolescents), and the presence of atopic dermatitis (AD) were identified. Results: Forty-nine patients (30.6%), 34 girls and 15 boys, exhibited positive patch test reactions to a minimum of one allergen, and contact sensitivity was statistically significant higher in girls (P=0.034). The 5 most frequent allergens were nickel sulfate (10.6%), methylchloroisothiazolinone (MCI)/methylisothiazolinone (MI) (8.1%), cobalt chloride (5.6%), p-phenylenediamine (PPD) (5%), and MI (3.5%). No significant association was observed between patch test positivity and age groups (p>.05). Nickel sulfate sensitivity was significantly higher in girls than boys (P=.043). A positive reaction was detected in 31.3% of patients with AD and in 33.7% of those without (P>.05) and a significant relationship was observed between contact sensitivity to fragrance allergens and AD (P=.046). Conclusion: Metals and preservatives represent the most frequent allergens in Turkish children and adolescents. Metal sensitivity is expected to decrease as legislation is enforced. Regulatory measures are now required to reduce MI and MCI/MI contact allergy in Turkey.
Status of Dermoscopy in Chile: First National Study for Dermatologists
Authors: Morales Etcheberry Juan Pablo , González-Coloma Francisco , Alonso-Traviesa Faustino , Vega-Almendra Nadia 
Published: June 2024

Introduction: Scientific evidence supports dermoscopy as an essential tool in dermatological diagnosis. Objectives: The objective is to know the factors that influence its use in Chilean dermatologists. Materials and Methods: Analytical cross-sectional study. An adapted version of the survey was submitted from the pan-European study by Forsea et.al. to members of the Chilean Society of Dermatology, between September and December 2020. Analysis using descriptive statistics and multivariate analysis with ordinal logistic regression looking for factors associated with greater use of. Results: 198 responses, mean age 46.3 years and 14.6 years on average practicing as dermatologists. 61.6% trained in dermoscopy during their residency. 98% use a dermatoscope. More than 80% consider dermoscopy useful for the diagnosis of melanomas, follow-up of melanocytic lesions, and diagnosis of pigmented and non-pigmented tumors. Between 50% and 70% consider it useful for monitoring non-melanocytic lesions, nail and hair pathologies. Greater confidence when evaluating pigmented and non-pigmented tumors and capillary pathology. Adjusting for age, sex, confidence, and education, participation in teaching was associated with greater use of dermoscopy in non-pigmented and pigmented tumors, and capillary pathology. Conclusions: Percentage of participation in the survey and training in dermoscopy higher than in the reference study, recognizing the usefulness of dermoscopy for the diagnosis and follow-up of tumor pathologies. Participating in teaching is a strong independent factor that is associated with a greater use of dermoscopy in Chile. Dermoscopy is positioned as a tool widely used by Chilean dermatologists in their daily practice.
Evaluation of the Quality of Life and the Demographic and Clinical Characteristics of Patients With Pemphigus With Oral Mucosal İnvolvement: A Multicenter Observational Study
Authors: Kara Polat Asude , Mülayim Mehmet Kamil , Falay Gür Tuğba , Acar Ayda , Bozca Burçin Cansu , Ceylan Can , Kılınç Fadime , Yasak Güner Rukiye , Albayrak Hülya , Durdu Murat , Koku Aksu Ayşe Esra , Nalbant Fatma , Şavk Ekin , Bayramgürler Dilek , Daye Munise , Singer Ralfi , Alataş Emine Tuğba , Erdemir Vefa Aslı , Gürel Mehmet Salih , Uzun Soner , Yaylı Savaş 
Published: June 2024

Introduction: Pemphigus vulgaris (PV) is an autoimmune disease that mostly affects the oral mucosa. Objectives: This study aimed to determine the demographic, clinical and treatment characteristics as well as the quality of life of patients with PV and oral mucosal involvement. Methods: We conducted a prospective observational study among 106 patients with PV and oral mucosal involvement. Demographic data, clinical and treatment characteristics, and quality of life questionnaires were recorded. Results: Of the 106 patients, 51.89% were males. Mucocutaneous subtype was found in 78.38% of the patients. The initial localization of 41.51% of the patients was only the oral mucosa. Involvement of the bilateral buccal mucosa was observed most frequently in the patients and burning was the most common symptom (85.85%). Oral mucosal examination revealed erosions in 85.85% of the patients. The most frequently used treatment agent in the patients was a systemic steroid, and rituximab used in 16.98% patients. A positive and significant correlation was found between pemphigus severity and OHIP14-TR, DLQI, and DYQS scores (p < 0.05). The quality of life was more significantly adversely affected in those with superficial ulcers, loose bullae, lesion diameter of 1 cm and above, and the number of lesions above 10 in the oral mucosa. Complet response was observed in all patients using rituximab. Conclusions: The most common area of involvement was bilateral buccal mucosa, and the quality of life was affected in correlation with the severity of the disease.
Đánh giá sinh lý bệnh động mạch vành: quá khứ, hiện tại và tương lai
Authors: Phạm Lê Minh , Hoàng Kim Quân , Phan Tuấn Đạt , Mai Trung Anh , Phạm Mạnh Hùng 
Published: June 2024

Tình trạng thiếu máu cục bộ cơ tim là yếu tố tiên lượng quan trọng ở bệnh nhân tim mạch. Phân suất dự trữ lưu lượng mạch vành (FFR) và những chỉ số không giãn mạch là những phương pháp xâm lấn để phát hiện và xác định tình trạng thiếu máu cơ tim do bệnh động mạch vành. Một số nghiên cứu ngẫu nhiên và các nghiên cứu sổ bộ với số lượng bệnh nhân lớn đã chứng minh lợi ích của việc đo các chỉ số sinh lý ở những bệnh nhân mắc bệnh động mạch vành. Ngoài ra, sự phát triển gần đây của các kỹ thuật hình ảnh và tính toán đã cho phép việc đánh giá sinh lý mạch vành dựa trên hình ảnh, và tích hợp những thông tin hình ảnh cùng với sinh lý từ các dữ liệu đánh giá xâm lấn cũng như là không xâm lấn. Trong bài báo này, chúng tôi xem xét việc đánh giá sinh lý mạch vành trong quá khứ, hiện tại cũng như triển vọng trong tương lai.
Development of cell-penetrating peptides targeting nuclear and extra-nuclear signaling pathways in cancer cells
Authors:   , Kaewjanthong Panthita 
Published: June 2024

Growth factors and hormones often mediate their biological effects through series of protein-protein interaction between cytoplasmic signaling molecules or transcription factors. Interfering of these protein-protein interactions has been shown to reduce or inhibit biological and growth responses to various growth factors and hormones. We previously demonstrated that progesterone receptor (PR) contains a polyproline domain (PPD) which directly interact to Src homology 3 (SH3) domain-containing molecules and expression of PR-PPD inhibits EGFR-mediated NSCLC cell proliferation. In this study, we investigated that the introduction of PR-PPD by cell-penetrating peptide could inhibit EGF-induced NSCLC cell proliferation. PR-PPD was attached to a cancer-specific CPP, Buforin2 (BR2), to help deliver the PR-PPD into NSCLC cells. Addition of BR2-2xPPD peptide containing two PR-PPD repeats was more effective in inhibiting NSCLC proliferation and significantly reduced EGF-induced phosphorylation of Erk1/2. BR2-2xPPD treatment could induce cell cycle arrest by inhibiting the expression of cyclin D1 and CDK2 gene in EGFR-wild type A549 cells. The combination treatment of EGFR-TKIs with BR2-2xPPD peptide was more effectively suppressed growth of NSCLC PC9 cells harboring EGFR mutation as compared to EGFR-TKIs treatment alone. Additionally, BR2-2xPPD peptide could mediate growth inhibition in acquired gefitinib- and erlotinib- resistance lung adenocarcinoma cells. In addition to PR-PPD, previous studies had demonstrated that peptide containing LXXLL motifs inhibited interactions between steroid hormone receptor and its coactivator. In this study, BR2-LXXLL peptide was designed from GRIP-1 protein which had high potential to inhibit ER transcription. The nuclear localization of SV40 was also added into peptide in order to facilitate access to nucleus. Our results demonstrated that BR2-LXXLL peptide could effectively inhibit the transcriptional activity of PR in T47DC42 breast cancer cell expressing PR-B isoform while the scramble peptide abolished this inhibition. BR2-LXXLL and BR2-2xPPD treatments dose-dependently decreased Estrogen-induced cell proliferation in ER-positive MCF-7 breast cancer cell lines. Moreover, BR2-LXXLL and BR2-2xPPD peptides also significantly reduced triple-negative breast cancer cell growth which lack of targeted therapy. Altogether, our data suggested that the cancer cell specific peptide of PR-PPD and LXXLL motifs could be used to further develop as novel anticancer treatment in the near future.