bluuebunny/crossref_metadata_2025_split huggingface dataset:
Diagnostic Accuracy of ACR/EULAR 2010 Criteria for Rheumatoid Arthritis in a 2-Year Cohort
Authors: VARACHE SOPHIE , CORNEC DIVI , MORVAN JOHANNE , DEVAUCHELLE-PENSEC VALÉRIE , BERTHELOT JEAN-MARIE , LE HENAFF-BOURHIS CATHERINE , HOANG SYLVIE , THOREL JEAN-BAPTISTE , MARTIN ANTOINE , CHALÈS GÉRARD , NOWAK EMMANUEL , JOUSSE-JOULIN SANDRINE , YOUINOU PIERRE , SARAUX ALAIN 
Published: May 2011

Objective.To evaluate the diagnostic accuracy of the 2010 American College of Rheumatology/European League Against Rheumatism (ACR/EULAR) and 1987 ACR criteria for rheumatoid arthritis (RA), and the respective role of the algorithm and scoring of the ACR/EULAR.Methods.In total, 270 patients with recent-onset arthritis of < 1 year duration were included prospectively between 1995 and 1997 and followed for 2 years. RA was defined as the combination, at completion of followup, of RA diagnosed by an office-based rheumatologist and treatment with a disease-modifying antirheumatic drug or glucocorticoid. We compared the sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) of the criteria sets in the overall population, in the subgroup meeting the tree condition for ACR/EULAR scoring, and in the overall population classified according the full tree.Results.At baseline, 111 of the 270 patients had better alternative diagnoses and 16 had erosions typical for RA; of the 143 remaining patients, 52 had more than 6 ACR/EULAR 2010 points (indicating definite RA) and 91 had fewer than 6 points. After 2 years, 11/16 patients with erosions and 40/52 with more than 6 points had RA. 100 of the 270 patients met the reference standard for RA. Sensitivity, specificity, PPV, and NPV of the ACR/EULAR (full tree) were 51/100 (51%), 153/170 (90%), 51/68 (75.4%), and 153/202 (75.7%), respectively. Diagnostic accuracies of the ACR/EULAR score and ACR 1987 criteria were not statistically different.Conclusion.Much of the improvement of the ACR/EULAR criteria was ascribable to the use of exclusion criteria in the algorithm.
Cost-Effectiveness of Combination Nonbiologic Disease-Modifying Antirheumatic Drug Strategies in Patients with Early Rheumatoid Arthritis
Authors: TOSH JONATHAN C. , WAILOO ALLAN J. , SCOTT DAVID L. , DEIGHTON CHRIS M. 
Published: May 2011

Objective.To compare the costs and benefits of alternative combination strategies of disease-modifying antirheumatic drugs (DMARD) and DMARD monotherapy in patients with early, active rheumatoid arthritis (RA).Methods.Data were drawn from randomized controlled trials that compared DMARD monotherapy or any DMARD combination strategy, with or without combined steroid therapy. Mixed treatment comparison methods were used to estimate the relative effectiveness of the different strategies. A mathematical model was developed to compare the longterm costs and benefits of the alternative strategies, combining data from a variety of sources. Costs were considered from a health sector viewpoint and benefits were expressed in terms of quality-adjusted life-years (QALY).Results.If decision makers use a threshold of £20,000 (US$29,000) per QALY, then the strategies most likely to be cost-effective are either DMARD combination therapy with downward titration (probability of being optimal = 0.50) or intensive, triple DMARD combination therapy (probability of being optimal = 0.43). The intensive DMARD strategy generated an additional cost of £27,392 per additional QALY gained compared to the downward titration strategy. Other combination strategies were unlikely to be considered cost-effective compared to DMARD monotherapy. Results were robust to a range of scenario sensitivity analyses.Conclusion.Combination DMARD therapy is likely to be cost-effective compared to DMARD monotherapy where treatment entails rapid downward dose titration or intensive, triple DMARD therapy.
Scanning of the Sacroiliac Joint and Entheses by Color Doppler Ultrasonography in Patients with Ankylosing Spondylitis
Authors: HU YIZHOU , ZHU JIAAN , XUE QING , WANG NIANSONG , HU BING 
Published: May 2011

Objective.To assess Doppler ultrasonography by comparing its detection of sacroiliitis with detection of enthesitis in patients with ankylosing spondylitis (AS).Methods.One hundred sixty-one patients with AS (according to modified New York criteria or Spondyloarthritis International Society classification criteria for axial spondyloarthritis) underwent ultrasonography (US) of the sacroiliac joint (SIJ) and major entheses of the lower limbs. Vascularization of the SIJ and morphologic changes and vascularization of entheses were observed. The resistive index of the SIJ was measured. Doppler ultrasonography examination was repeated in 20 patients by another ultrasonographer.Results.In the AS active group [Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) ≥ 4], 90.7% of SIJ showed vascularization; this was significantly more than in the inactive group (38.5%). The resistive index of the active group in the SIJ area was significantly lower than that of the inactive group. Doppler US scanning of the SIJ was more sensitive (92.0%) than that of the entheses (52.2%). Agreement of Doppler US scanning of the SIJ and BASDAI was good, while agreement of the entheses and BASDAI was poor.Conclusion.Lower resistive index value and vascularization in the SIJ had good agreement with AS activity. Doppler US is more sensitive in detecting sacroiliitis than in detecting enthesitis.
Continuation of Methotrexate Resulted in Better Clinical and Radiographic Outcomes Than Discontinuation upon Starting Etanercept in Patients with Rheumatoid Arthritis: 52-week Results from the JESMR Study
Authors: KAMEDA HIDETO , KANBE KATSUAKI , SATO ERI , UEKI YUKITAKA , SAITO KAZUYOSHI , NAGAOKA SHOUHEI , HIDAKA TOSHIHIKO , ATSUMI TATSUYA , TSUKANO MICHISHI , KASAMA TSUYOSHI , SHIOZAWA SHUNICHI , TANAKA YOSHIYA , YAMANAKA HISASHI , TAKEUCHI TSUTOMU 
Published: May 2011

Objective.The aim of the Efficacy and Safety of Etanercept on Active Rheumatoid Arthritis Despite Methotrexate Therapy in Japan (JESMR) study is to compare the efficacy of continuation versus discontinuation of methotrexate (MTX) when starting etanercept (ETN) in patients with active rheumatoid arthritis (RA).Methods.In total, 151 patients with active RA who had been taking MTX were randomized to either ETN 25 mg twice a week with 6–8 mg/week MTX (the E+M group), or ETN alone (the E group). The primary endpoint at Week 52 was the radiographic progression assessed by van der Heijde-modified Sharp score.Results.The mean progression in total score at Week 52 was not significantly different, statistically, between the E+M group and the E group (0.8 vs 3.6, respectively; p = 0.06). However, a significant difference was observed in radiographic progression between Weeks 24 and 52 (0.3 vs 2.5; p = 0.03), and the mean progression of the erosion score was negative in the E+M group, which was significantly better than the E group at Week 52 (–0.2 vs 1.8; p = 0.02). Clinically, the cumulative probability plot of the American College of Rheumatology (ACR)-N values at Week 52 clearly demonstrated a superior response in the E+M group than in the E group. ACR20, 50, and 70 response rates at Week 52 in the E+M group (86.3%, 76.7%, and 50.7%) were significantly greater than those in the E group (63.8%; p = 0.003, 43.5%; p < 0.0001 and 29.0%; p = 0.01, respectively).Conclusion.MTX should be continued when starting ETN in patients with active RA. (ClinicalTrials.gov: NCT00688103)
Using resistivity logs to estimate hydraulic conductivity of a Nubian sandstone aquifer in southern Egypt
Authors: Khalil Mohamed A. , Ramalho Elsa C. , Monteiro Santos Fernando A. 
Published: May 2011

ABSTRACTThe present study was carried out in the Khor‐El‐Ramlah area, in a Nubian sandstone aquifer. It is located in the western bank of Nasser Lake, southern Egypt, in a tectonically active area, which is dissected by many regional faults extending towards the lake. For this reason, the Nubian sandstone aquifer in this area is expected to be recharged by a large amount of seepage water from the lake. One important parameter used to quantify seepage is hydraulic conductivity. Since in this area there is no available information about hydraulic conductivity via pumping tests or laboratory examination of core samples, an attempt is made in this study to estimate hydraulic conductivity using available resistivity logs by applying the Kozeny‐Carman model. The clay contamination effect on porosity estimation has been removed via application of the Waxman‐Smits model. The hydraulic conductivity is estimated to be 9.5 ± 2.5 m/day for the Nubian sandstone aquifer in this area. The present result is in agreement with the estimated and measured hydraulic conductivity values for the same aquifer in nearby areas and could be used to estimate seepage in this zone. The application of geophysical well logging often provides a cost‐effective and efficient alternative to estimate aquifer parameters.
Experimental study of near‐field effects in multichannel array‐based surface wave velocity measurements
Authors: Li Jianhua , Rosenblad Brent 
Published: May 2011

ABSTRACTThis paper examines the influence of source offset distance on surface wave phase velocity values determined from frequency‐wavenumber processing of multi‐channel data. Experimental surface wave data were collected over a broad range of frequencies at eleven deep soil sites in the Mississippi embayment of the central United States. Using analyses of multiple array configurations at each site, near‐field phase velocity values (determined with the source close to the array) were compared to far‐field velocity values. The source offset distance was expressed as a normalized value calculated as the distance from the source to the centre of the array, divided by the wavelength. The results from these field measurements showed that the influence of near‐field effects became evident when the normalized source offset distance was 0.5 or less, a value that is less restrictive than values determined from a recent study of near‐field effects using numerical simulations and experimental data. A possible reason for this discrepancy is the high Poisson’s ratio values in this study due to shallow water tables at the field test sites, a condition that was not examined in the previous study. Last, the effectiveness of processing using cylindrical beamforming for mitigating near‐field effects is also examined in this study and shown to provide a small improvement in velocity estimates in the near‐field.
Preoperative Vascular Endothelial Growth Factor Levels as a Prognostic Marker for Stage II or III Colorectal Cancer Patients
Authors: Kemik Ozgur , Kemik Ahu Sarbay , Sümer Aziz , Purisa Sevim , Dulger A. Cumhur , Begenik Hüseyin , Hasirci Ismail , Tuzun Sefa 
Published: May 2011

Background The aim of the present study was to determine whether serum vascular endothelial growth factor (VEGF) can provide prognostic information independent of carcinoembryonic antigen levels in patients undergoing curative surgery. Methods Serum samples were collected from 158 patients with colorectal cancer and from 100 controls. Serum and tissue levels of VEGF were measured by enzyme-linked immunosorbent assay. Serum VEGF levels in colorectal cancer patients were compared with those in healthy controls, and we retrospectively assessed the association between serum VEGF levels and clinicopathologic findings and survival. Results VEGF expression was significantly higher in colorectal cancer tissue compared with nontumor tissue. Mean serum VEGF levels in patients were significantly higher than those in controls, and significantly higher in patients with large tumors, lymph node involvement, and distant metastases. Conclusion Elevated serum VEGF was significantly associated with poor survival, but was only an independent risk factor for poor survival in Stage II and/or III disease. Elevated serum VEGF is significantly associated with development of colorectal cancer, and lymph or distant invasive phenotypes and survival, especially in Stage II and III patients.
Tipografía y color, un análisis de la prensa gratuita vs. la prensa de pago en España
Authors: Del Olmo Barbero Jesús , Parratt Fernández Sonia 
Published: May 2011

Este artículo pretende delimitar el modelo de diario gratuito desde el punto de vista formal, en base a su diseño, con especial incidencia en el formato, la tipografía y el color. Para definir su modelo, lo hemos comparado con la prensa de pago. El método empleado es el análisis cuantitativo, de tipo comparado, basado en el estudio de caso. La muestra utilizada comprende ocho diarios editados en España, los cuatro gratuitos de mayor tirada (Qué!, 20 Minutos, Metro Directo y Adn) y los cuatro que lideran el mercado de pago (El Mundo, El País, Abc y La Vanguardia). En el marco de una investigación mucho más amplia que pretende definir el modelo de los gratuitos desde el punto de vista de los emisores, del producto y de la audiencia, en este trabajo se presentan los resultados correspondientes al diseño del producto: una evidente similitud de formatos que esconde diferencias muy sutiles en el tratamiento de la tipografía y el color.
Protein Glycosylation: Analysis, Characterization, and Engineering
Authors: Andersen Mikael R. , Hyun Nam Jong , Sharfstein Susan T. 
Published: May 2011

AbstractProtein glycosylation is critically important in vivo; current estimates are that more than half of the proteins in the SWISS‐PROT database are glycoproteins. Glycosylation plays a substantial role wide a range of physiological and pathological processes including development, immunology, cancer, and infectious disease. Protein glycosylation is also vitally important in the development of therapeutic bioproducts. Currently, more than 165 recombinant protein pharmaceuticals are approved for human use, with another 500 in preclinical and clinical trials. Of these, approximately 70% are glycosylated proteins. Glycosylation affects the structure, activity, immunogenicity, protease sensitivity, stability, and biological clearance of glycoproteins. Hence, an understanding of the mechanisms by which proteins are glycosylated, and strategies for analyzing and controlling glycoforms has become increasingly important in the development of biopharmaceuticals. Advances in chromatography and mass spectrometry have permitted more detailed identification of glycans, while cellular and protein engineering strategies have allowed manipulation of the glycoforms. In this chapter, we review the biology of protein glycosylation, methods for identifying and characterizing glycans and glycoproteins, and the effects of host cell line, culture conditions, and cellular engineering on the glycoforms of recombinant glycoproteins, providing a comprehensive overview of glycosylation of recombinant protein therapeutics.
“Official” and “practical” kin: Inferring social and community structure from dental phenotype at Neolithic Çatalhöyük, Turkey
Authors: Pilloud Marin A. , Larsen Clark Spencer 
Published: May 2011

AbstractThe Neolithic site of Çatalhöyük, Turkey (7400–5600 cal BC) is widely acknowledged for its role in the study of early farming communities. To better understand the social and community structure of this setting, an intracemetery biological distance analysis was conducted. Metric and nonmetric observations were recorded in both deciduous and permanent dentitions (n = 266) to explore phenotypic patterning of individuals interred within individual buildings. Specifically, this study tests the hypothesis that individuals within houses and house groupings represent family units and the social structure of Çatalhöyük was largely biological‐kin based. Multivariate and univariate statistical procedures were applied to phenotypic dental data. Results indicate that inclusion for interment within a house was only minimally related to biological affinity. Moreover, the site does not appear to be organized into larger, biologically related neighborhoods of houses. These findings suggest that Çatalhöyük may not have been a kin‐based society, largely because membership within a house cemetery was not solely defined on the basis of biological affinity, such as in a family group. Rather, it appears that social structure was centered on the house as the unifying social principle. The choice for interment location may have transcended biological lines thereby creating an alternate and more fluid definition of “kin.” These findings can be used to understand the transition to settled life and biological patterning in this Neolithic community. Am J Phys Anthropol 2011. © 2011 Wiley‐Liss, Inc.
Power system lightning transient simulation on OrCAD with corona effect consideration for educational purposes
Authors: Vahidi B. , Tabatabaei S. M. , Baharlou M. M. 
Published: May 2011

ABSTRACTThis article describes an efficient method of teaching lightning transient on power system, to undergraduate students of power system groups in electrical engineering departments, as a part of a high voltage course for senior undergraduate students. The article shows how to simulate the components of power system in order to teach students the basics of lightning transient phenomena, and to practice the simulation of power system components. In the first part of the article the simulation of component is described, and in the second part a system is simulated for lightning transient study. Evaluation of the simulation over several semesters with more than 48 students is very positive in terms of their developing confidence in and understanding of lightning transient phenomena. © 2011 Wiley Periodicals, Inc. Comput Appl Eng Educ 22:266–271, 2014; View this article online at wileyonlinelibrary.com/journal/cae; DOI 10.1002/cae.20552
Malignant biphasic peritoneal mesothelioma in a child: Fine‐needle aspiration cytology, Histopathology, and immunohistochemical features along with review of literature
Authors: Arora Sandeep Kumar , Srinivasan Radhika , Nijhawan Raje , Bansal Deepak , Menon Prema 
Published: May 2011

AbstractPeritoneal mesotheliomas in children are of rare occurrance. We herein report the clinical, radiological, and pathological findings of a rare case of malignant peritoneal mesothelioma occurring in nine‐year‐old female child. The child presented with abdominal distension and awareness of a painless mass in the abdomen which on radiology appeared as a large heterogeneous pelvic mass with peritoneal deposits at multiple sites. To the best of our knowledge, this is the first case of a peritoneal malignant mesothelioma on which fine needle aspiration (FNA) was performed as first line investigation of the primary tumor. The cytological features, major differential diagnoses, and the pitfalls therein are discussed. Histopathology revealed biphasic pattern of mesothelioma which is again a rare pattern. Immunochemistry was carried out on the cell block made from the FNA as well as the biopsy specimen essentially showed the same features. There was positivity for vimentin, EMA, and cytokeratin 5/6 while WT1, calretinin, and CEA were negative; however, D2‐40 showed diffuse membranous positivity in the epithelial areas and cytoplasmic positivity in the spindle areas confirming a mesothelioma. We emphasize the use of immunochemistry on cell block material for a confident diagnosis of mesothelioma in such cases. Diagn. Cytopathol. 2012. © 2011 Wiley Periodicals, Inc.
Partially redundant functions of Adamts1 and Adamts4 in the perinatal development of the renal medulla
Authors: Boerboom Derek , Lafond Jean‐François , Zheng Xiaofeng , Lapointe Evelyne , Mittaz Laureane , Boyer Alexandre , Pritchard Melanie A. , DeMayo Francesco J. , Mort John S. , Drolet Richard , Richards Joanne S. 
Published: May 2011

AbstractAdamts4 encodes a widely‐expressed proteinase thought to be involved in processes ranging from cartilage metabolism to ovarian follicle development. To study its physiological roles, Adamts4‐null mice were created by gene targeting. Unexpectedly, these were found to be phenotypically normal, suggesting that other gene(s) may compensate for its loss. Adamts4−/− mice were, therefore, crossed with a strain lacking Adamts1, whose pattern of expression and substrate specificity overlap that of Adamts4. Most (>95%) Adamts1−/−;Adamts4−/− mice died within 72 hr after birth with a marked thinning of the renal medulla. The renal defect was not observed in embryonic Adamts1−/−;Adamts4−/− kidneys, but became apparent around birth. The few (<5%) Adamts1−/−;Adamts4−/− animals to reach adulthood had the same renal phenotype seen in newborns. This study is thus the first to report Adamts4 expression and function in the mammalian kidney, and to demonstrate that Adamts1 and Adamts4 play redundant and essential roles in perinatal kidney development. Developmental Dynamics 240:1806–1814, 2011. © 2011 Wiley‐Liss, Inc.
Experimental tests on full‐scale RC unretrofitted frame and retrofitted with buckling‐restrained braces
Authors: Di Sarno L. , Manfredi G. 
Published: May 2011

SUMMARYThe results of experimental tests carried out on reinforced concrete (RC) full‐scale 2‐storey 2‐bays framed buildings are presented. The unretrofitted frame was designed for gravity loads only and without seismic details; such frame was assumed as a benchmark system in this study. A similar RC frame was retrofitted with buckling‐restrained braces (BRBs). The earthquake structural performance of both prototypes was investigated experimentally using displacement‐controlled pushover static and cyclic lateral loads. Modal response properties of the prototypes were also determined before and after the occurrence of structural damage. The results of the dynamic response analyses were utilized to assess the existing design rules for the estimation of the elastic and inelastic period of vibrations. Similarly, the values of equivalent damping were compared with code‐base relationships. It was found that the existing formulations need major revisions when they are used to predict the structural response of as‐built RC framed buildings. The equivalent damping ratio ξeq was augmented by more than 50% when the BRBs was employed as bracing system. For the retrofitted frame, the overstrength Ω and the ductility µ are 1.6 and 4.1, respectively; the estimated R‐factor is 6.5. The use of BRBs is thus a viable means to enhance efficiently the lateral stiffness and strength, the energy absorption and dissipation capacity of the existing RC substandard frame buildings. The foundation systems and the existing members of the superstructure are generally not overstressed as the seismic demand imposed on them can be controlled by the axial stiffness and the yielding force of the BRBs. Copyright © 2011 John Wiley & Sons, Ltd.