bluuebunny/crossref_metadata_2025_split huggingface dataset:
Current Perspectives on Extensive Applications of Nanocochleates-based
Drug Delivery
Authors: Bhosale Rohit R. , Chavan Dhanashri D. , Janugade Bhagyesh U. 
Published: May 2024

Abstract:
Enhancing therapeutic efficacy stands as a pivotal concern across various medical conditions.
Traditional therapeutic approaches have encountered limitations in addressing numerous
issues. Over the recent years, the integration of nanotechnology has successfully overcome these
obstacles, ushering in a new era of advanced treatment modalities. One notable stride has been the
utilization of lipid-based nanocarriers, which have demonstrated substantial improvements in therapeutic
outcomes. Among these innovative drug delivery systems (lipid-based), nanocochleates
have emerged as the focal point for augmenting therapeutic potential and enabling targeted actions.
Originally employed for vaccines, genes, and fungal infections, nanocochleates have
evolved to address significant life-threatening diseases where conventional therapies fall short.
The distinctive capability of nanocochleates lies in their ability to deliver drugs with enhanced precision
in comparison with supplementary lipid-based systems, making them a promising novel carrier
for improved efficacy. This piece of writing delves into the fundamentals of nanocochleates,
exploring their safety and stability aspects, recent trends, and diverse applications. Notably, nanocochleates
have shown promise in managing conditions such as diabetes mellitus, malaria, leishmaniasis,
cancer, viral infections, and osteoporosis. By elucidating the unique attributes and potential
of nanocochleates, this review aims to contribute valuable insights into their role as a cutting-
edge drug delivery system across a spectrum of critical medical scenarios
CNS Delivery Systems Based on Nanotechnology with Particular
Attention to Parkinson's and Alzheimer's Disease –A Review
Authors: Ahmad Md Makhmur , S Alshammari Abdulla Obaid , Alshammari Maher Abbas , A Alshammari Hatim Obaid , M. Aldhabi Bander , Q. Alruwaytie Muqbil , D. Alhejaili Omar 
Published: May 2024

Abstract::
Nanotechnology has emerged as a promising frontier in the field of drug delivery,
offering unprecedented opportunities for precise and targeted interventions in neurodegenerative
disorders, such as Parkinson's and Alzheimer's diseases. This review explores
recent advancements in nanotechnology-based delivery systems designed to enhance drug
transport across the blood-brain barrier and facilitate targeted drug delivery to the central
nervous system. The unique challenges posed by the intricate central nervous system architecture,
particularly in the context of Parkinson's and Alzheimer's diseases, necessitate innovative
solutions to improve therapeutic outcomes. The review comprehensively discusses
various nanocarrier platforms, including liposomes, polymeric nanoparticles, dendrimers,
and exosomes, and their potential applications in drug delivery to the central
nervous system (CNS). Special emphasis is placed on addressing the multifaceted challenges
associated with neurodegenerative diseases, such as the need for sustained drug
release, protection of therapeutic agents from enzymatic degradation, and the efficient
crossing of the blood-brain barrier. Furthermore, the review highlights recent breakthroughs
in nanotechnology-driven diagnostic and therapeutic approaches, ranging from
early detection of disease biomarkers to the targeted delivery of neuroprotective agents.
The potential of personalized medicine and the integration of advanced imaging techniques
with nanotechnology for precise disease monitoring are also discussed. In conclusion, this
review provides a comprehensive overview of recent advancements in nanotechnologybased
delivery systems tailored for CNS targeting, with a specific focus on Parkinson's and
Alzheimer's diseases. The synthesis of current research findings underscores the transformative
potential of nanotechnology in reshaping the landscape of therapeutic strategies
for neurodegenerative disorders, offering hope for improved patient outcomes and the development
of novel treatment modalities.
Pre-clinical Efficacy and Immunogenicity of IgY Antibodies Directed
against Crotalus durissus cumanensis Venom
Authors: Montero Yuyibeth , Zerpa Noraida , Neves Yudith , Zerpa Oriana , Álvarez Aurora , Malavé Caridad 
Published: May 2024

Background:
Crotalus durissus cumanensis (C.d.c.) is the most widely distributed snake in Venezuela, causing the majority of snakebite envenoming

Objective:
The purpose of this study was to produce IgY antibodies against a C.d.c. venom pool from different Venezuelan regions and evaluate their neutralization capacity on various venom toxic activ-ities.

Methods:
Anti-C.d.c. venom antibodies are purified from chicken egg yolks by precipitation with polyethylene glycol and further analyzed by Multiple Antigen Blot Assay, indirect ELISA, Western blot, and Inhibition assays. In addition, we evaluate the phospholipase, edematogenic, and hemor-rhagic activities. In addition, a new envenoming simulation study using anti-C.d.c. venom IgY in mice is presented.

Results:
In this study, we show that anti-C.d.c. venom IgY is capable of neutralizing 4LD50 doses of the Cdc venom (i.e., 1.76 mg of IgY neutralized 14 μg of C.d.c. venom) and effectively neutralizing the phospholipase, edematogenic and hemorrhagic activities. Additionally, the anti C.d.c. venom IgY specifically recognizes polypeptide bands with apparent molecular masses of ~ 54.55, 30.39, 24.1, 14.02, and 9.44 kDa by western blot. The IgY specificity is demonstrated by a dose-dependent inhi-bition, in which antibodies pre-adsorbed with the C.d.c. venom does not recognize the proteins con-tained in the venom. Furthermore, in the simulation study of envenoming, the mice inoculated with IgY showed no response.

Conclusion:
Our results support the use of anti-venom IgY as an alternative to traditional equine therapy in animals and, eventually, in human patients bitten by C.d.c snakes.
New Insights on Mechanisms and Therapeutic Targets of Cerebral Edema
Authors: Shang Pei , Zheng Ruoyi , Wu Kou , Yuan Chao , Pan Suyue 
Published: May 2024

:
Cerebral Edema (CE) is the final common pathway of brain death. In severe neurological
disease, neuronal cell damage first contributes to tissue edema, and then Increased Intracranial Pressure (ICP) occurs, which results in diminishing cerebral perfusion pressure. In turn, anoxic brain injury brought on by decreased cerebral perfusion pressure eventually results in neuronal cell impairment,
creating a vicious cycle. Traditionally, CE is understood to be tightly linked to elevated ICP, which ultimately generates cerebral hernia and is therefore regarded as a risk factor for mortality. Intracranial
hypertension and brain edema are two serious neurological disorders that are commonly treated with
mannitol. However, mannitol usage should be monitored since inappropriate utilization of the substance could conversely have negative effects on CE patients. CE is thought to be related to bloodbrain barrier dysfunction. Nonetheless, a fluid clearance mechanism called the glial-lymphatic or
glymphatic system was updated. This pathway facilitates the transport of cerebrospinal fluid (CSF) into the brain along arterial perivascular spaces and later into the brain interstitium. After removing solutes from the neuropil into meningeal and cervical lymphatic drainage arteries, the route then directs
flows into the venous perivascular and perineuronal regions. Remarkably, the dual function of the
glymphatic system was observed to protect the brain from further exacerbated damage. From our point
of view, future studies ought to concentrate on the management of CE based on numerous targets of
the updated glymphatic system. Further clinical trials are encouraged to apply these agents to the clinic
as soon as possible.
Lower-Dosage Acute Peritoneal Dialysis versus Acute Intermittent Hemodialysis in Acute Kidney Injury
Authors: Parapiboon Watanyu , Tatiyanupanwong Sajja , Khositrangsikun Kamol , Phulkerd Thanawat , Kaewdoungtien Piyanut , Pichitporn Watthikorn , Lumlertgul Nuttha , Peerapornratana Sadudee , Chen Fangyue , Srisawat Nattachai 
Published: May 2024

Key Points

The efficacy of acute peritoneal dialysis is still controversial.There was no significant difference in 28-day mortality between acute peritoneal dialysis and intermittent hemodialysis.

Background
Lower delivered dose of acute peritoneal dialysis (PD) in AKI requires less resources but raises concerns regarding adequate solute and water clearance. The relative merits of lower-dose PD versus intermittent hemodialysis remain uncertain.

Methods
A multicenter randomized controlled trial compared the outcomes between acute lower-dosage PD (18–24 L per day) and intermittent hemodialysis (three times per week) from May 2018 to January 2021 in patients with AKI. The primary outcome was 28-day mortality rate. Secondary outcomes included 28-day dialysis-free survival and kidney recovery, metabolic profile, and procedure-related complications. Noninferiority of PD to hemodialysis would be demonstrated if the upper bound of the 95% confidence interval ( CI) on risk difference (PD-hemodialysis) in 28-day mortality rates between the two groups was <20%.

Results
We included 157 patients (80 allocated to PD and 77 to intermittent hemodialysis). Before KRT initiation, baseline clinical characteristics between groups were comparable. The overall mean age was 57±15 years. The most frequent cause of AKI was sepsis (68%). There was no difference in 28-day mortality between acute PD and intermittent hemodialysis (50% versus 49%, risk difference 0.6 [95% CI, −15.0 to 16.3]), and 28-day dialysis-free survival (42% versus 37%, risk difference 4.6 [95% CI, −11.1 to 20.3]). Mean weekly Kt/V urea was 2.11±1.14 and 2.55±1.11 in the PD and intermittent hemodialysis groups, respectively. The 7-day fluid balance of PD and intermittent hemodialysis patients was not significantly different. There was more frequent intradialytic hypotension in the intermittent hemodialysis group and more frequent hypokalemia in the PD group.

Conclusions
In this study of patients with AKI, there was no significant difference in 28-day mortality between acute PD and intermittent hemodialysis.
Impact of Scientific Agricultural Technologies on Livelihood Security of Tribal Farmers in Assam
Authors: Sharma Haridra , Mishra Prasanta 
Published: May 2024

The study was conducted during December, 2019 to December, 2021 at Assam Agricultural University, Jorhat, Assam, india with an objective to examine the impacts of scientific agricultural technologies on tribal livelihood security. Ex-post-fact research design was adopted to collect data from 400 tribal farmers from four tribal dominated districts viz., Chirang, Kokrajhar, Dhemaji and Karbi Anglong of Assam. Impacts weremeasured in terms of Livelihood Security Index (LSI) and Livelihood Endowment Status (LES) developed by Abadi (2010). When assessed on the basis of LSI, overall 31.00% shift was observed in case of beneficiary tribal farmers on before and after basis. LES was assessed comparing the beneficiary tribal farmers with non-beneficiary tribal farmers and the data revealed significant difference of 26.00% between the two groups. However, it was evident from the investigation that time gap in input supply, non-availability of suggested inputs locally after project period, high cost of inputs, lack of own capital to maintain the enterprises, difficulty in maintaining accounts etc. were the foremost problems faced by majority of the respondents.
PREDIKSI PRODUK DISKON UNTUK PENJUALAN KOKO SHOPE MENGGUNAKAN ALGORITMA APRIORI
Authors: Imran Muhammad Khamjah Bin , Seniwati Erni 
Published: May 2024

Koko shope merupakan sebuah toko yang menjual barang-barang yang berhubungan dengan k-pop. Seiring berjalan nya waktu, data transaksi pada koko shope semakin menumpuk dan hal ini akan sia-sia apabila dibiarkan begitu saja. Algoritma Apriori adalah suatu algoritma yang digunakan untuk penentuan frequent itemsets pada aturan asosiasi Boolean. Algoritma apriori termasuk jenis aturan asosiasi pada data mining. Analisis asosiasi atau association rule adalah tehnik pada data mining yang di gunakan untuk menemukan aturan suatu kombinasi item. Suatu aturan asosiasi dapat diketahui dengan dua parameter , yaitu support dan confidence. Support (nilai penunjang) adalah presentase kombinasi item tersebut dalam basis data, sedangkan confidence (nilai kepastian) adalah kuatnya hubungan antar item dalam aturan asosiasi Keluaran dari algoritma ini merupakan sebuah aturan asosiasi yang terdiri dari beberapa kombinasi itemset, yang bisa digunakan untuk membantu dalam memperbaiki pengambilan keputusan dimasa yang akan datang. Salah satu manfaat dari pengambilan keputusan ini adalah sebagai bahan rekomendasi pembuatan sebuah bundel diskon barang berdasarkan aturan asosiasi yang terbentuk agar promo yang dibuat dapat tepat sasaran dan sesuai kebutuhan pasar.
ANALISIS DAN PENGUJIAN SISTEM KEAMANAN PADA JARINGAN WIFI
Authors: Hidayat Ifan , Andriani Ria , Kurniadi Cessaricki Yudi , Ardianto Ari 
Published: May 2024

Pada perkembangan teknologi, kehidupan manisia saat ini sulit di pisah dengan teknologi informasi dan komunikasi. Contoh dari teknologi komunikasi dan informasi adalah jaringan wireless. Tidak bisa kita pungkiri hampir di semua tempat ada wireless, misal di kantor, sekolah, kedai, dan laininya. Terkadang banyak orang tidak menyadar bahwa kerentanan keamanan data pada jaringan sangat rawan. Pada proses bertukarnya data banyak celah di jaringan wireless itu.. Peneliti ingin membantu untuk beberapa cara untuk meminimalisir terjadinya kerentanan data keamanan hal itu, terutama pada sistem keamanan wireless. Pada jaringan wireless ada 3 tols sitem keamananya, yaitu WPA, WPA2 serta MAC Filtering. Pada keamanan jaringan wireless menggunakan WPA yaitu mengunakan password default. Keamanan ini sangat rentang, karena WPA menggunkan password default. Pada jaringan wireless menggunakan sitem keamanan WPA2 in dimana menggunakan password yang telah terenkripsi. Sedangkan MAC Filterng ini yatu. Membatasi mana user yang terdaftar dan dimana user yang tidak terdaftar pada jaringan wareless. Kami peneliti juga memberi tahu salah satu cara orang yang tidak bertanggung jawab bagaimana cara masuk kesebuah jaringan wareless, dengan cara menggunakan Airgeddon.
PERANCANGAN SISTEM INFORMASI WISATA DI YOGYAKARTA BERBASIS WEB
Authors: Mujito Mujito , Andriani Ria , Abdillah Ifan Wahyu , Arditya Vikha Hendra 
Published: May 2024

Informasi sangat mudah kita dapatkan sesuai dengan yang kita butuhkan dengan Teknologi Informasi. Dalam dunia Teknologi Informasi serta Informasi Internet merupakan tempat yang paling berperan. Informasi tentang objek-objek wisata dijogja belum cukup memadai,sehingga mengakibatkan wisatawan tidak mengetahui adanya beberapa objek wisata yang didalamnya sangat potensial.Oleh sebab itu perlu diatasi dengan adanya promosi dan penyediaan informasi berbasis website. Sistem informasi yang berbasis website ini mencakup di dalamnya unsur teks, gambar dan video. Media ini menjadi menarik karena unsur tersebut. Penerapan teknologi informasi wisata berbasis web mempermudah wisatawan jogja dalam memperoleh informasi yang lebih efektif dan sekaligus mempromosikan Daerah Istimewa Yogyakarta.
Simulation of the Hydrodealkylation of Toluene Using Conversion Reactor
Authors: Agustriyanto Rudy , Setyopratomo Puguh , Mochni Endang Srihari , Purwanto Edy 
Published: May 2024

Abstract—The hydrodealkylation of toluene is frequently used to produce the more valuable compound benzene. This process is widely employed in the petrochemical industry. Through hydrodealkylation, toluene undergoes a transformation, resulting in the production of valuable chemicals such as benzene and diphenyl. The objective of this study is to present the results obtained from simulating the process of toluene dealkylation using Aspen HYSYS. The feed to the reactor must contain toluene and hydrogen, while the recommended operating conditions are at 500 oC to 650 oC and 20 to 40 atm pressure to achieve 90% conversion. For this purpose, a conversion reactor has been selected as the preferred type. The simulation outcomes are particularly valuable during the initial stages of designing a production facility for benzene. The mass and energy balance calculations can be easily performed using Aspen HYSYS. Future research may focus on investigating different reactor types while considering the kinetics of the reaction.
Keywords: aspen HYSYS, hydrodealkylation, simulation, toluene

Abstrak—Hidrodealkilasi toluena sering digunakan untuk menghasilkan senyawa yang lebih bernilai yaitu benzene. Proses ini banyak digunakan dalam industri petrokimia. Melalui hidrodealkilasi, toluena mengalami transformasi, menghasilkan bahan kimia berharga seperti benzene dan diphenyl. Tujuan dari penelitian ini adalah untuk menyajikan hasil yang diperoleh dari mensimulasikan proses dealkilasi toluena menggunakan Aspen HYSYS. Umpan ke reaktor harus mengandung toluena dan hidrogen, sedangkan kondisi operasi yang direkomendasikan adalah pada suhu 500 oC hingga 650 oC dan tekanan 20 hingga 40 atm untuk mencapai konversi 90%. Untuk tujuan ini, reaktor konversi telah dipilih sebagai tipe yang disukai. Hasil simulasi sangat berharga selama tahap awal perancangan fasilitas produksi benzene. Perhitungan neraca massa dan energi dapat dengan mudah dilakukan menggunakan Aspen HYSYS. Penelitian masa depan dapat fokus pada penyelidikan berbagai jenis reaktor sambil mempertimbangkan kinetika reaksi.
Kata kunci: aspen HYSYS, hidrodealkilasi, simulasi, toluene
The evolution of technology and the transformation of the banking sector under the influence of digital trends
Authors: Miroshnichenko N. V. , Donskova Yu. I. 
Published: May 2024

Banks have been using technology for decades to improve their operations. However, the pace of digital transformation has accelerated in recent years.The impact of digital transformation on the banking sector is very significant. Traditional banks must adapt to the changing digital landscape or risk losing customers to more digitally savvy competitors. One of the most significant consequences of digital transformation for ordinary banks is the change in customer expectations. Now customers expect uninterrupted and efficient banking services through all channels, including digital ones. This forces ordinary banks to invest in digital technologies in order to remain competitive.Another impact of digital transformation on conventional banks is the change in the way banks interact with customers. In the past, banks used physical branches as the main means of interacting with customers. Something more is needed to remain competitive. Banks now have to interact with customers through several channels, including mobile apps, online portals and chatbots.All these and many other digital innovations are transforming the banking sector and necessitate the study of these phenomena.
Working with bloggers as an effective tool for promoting a telecommunication company
Authors: Molchanov S. S. 
Published: May 2024

The article analyzes the use of bloggers as an effective tool for promoting telecommunications companies on social networks and video hosting sites. The author examines in detail the key advantages of cooperation with influencers, such as increasing brand awareness, significantly expanding the reach of the target audience, increasing sales, increasing consumer engagement and loyalty, as well as improving the company’s image as modern and keeping up with digital trends.The article highlights the potential risks of working with bloggers, including the high cost of popular influencers, the possibility of encountering low–quality blogging sites with fake audiences, the threat of reputational losses, legislative restrictions in the field of advertising certain services and the lack of full control over the content created by the blogger.To minimize risks and increase the effectiveness of collaborations, the author gives detailed recommendations on the selection of suitable bloggers. Among the key criteria are: the correspondence of the blogger’s audience to the company’s target audience, a high level of subscriber engagement, the relevance of content to the brand’s theme, successful experience in advertising integrations, as well as adequate cost of services. Telecommunications companies are advised to use special social media monitoring services to analyze the quality of the audience of influencers.In conclusion, it is emphasized that a systematic approach to planning advertising campaigns with bloggers, constant monitoring of their implementation and a comprehensive assessment of results on a number of qualitative and quantitative indicators will allow telecommunications companies to maximize the benefits of cooperation with influencers and achieve high efficiency of investments in blogger marketing.
Clinical complexity of an Italian cardiovascular intensive care unit: the role of mortality and severity risk scores
Authors: Troisi Federica , Guida Pietro , Vitulano Nicola , Argentiero Adriana , Passantino Andrea , Iacoviello Massimo , Grimaldi Massimo 
Published: May 2024

Aims
The identification of patients at greater mortality risk of death at admission into an intensive cardiovascular care unit (ICCU) has relevant consequences for clinical decision-making. We described patient characteristics at admission into an ICCU by predicted mortality risk assessed with noncardiac intensive care unit (ICU) and evaluated their performance in predicting patient outcomes.

Methods
A total of 202 consecutive patients (130 men, 75 ± 12 years) were admitted into our tertiary-care ICCU in a 20-week period. We evaluated, on the first 24 h data, in-hospital mortality risk according to Acute Physiology and Chronic Health Evaluation II (APACHE II) and Simplified Acute Physiology Score 3 (SAPS 3); Sepsis related Organ Failure Assessment (SOFA) Score and the Mayo Cardiac intensive care unit Admission Risk Score (M-CARS) were also calculated.

Results
Predicted mortality was significantly lower than observed (5% during ICCU and 7% at discharge) for APACHE II and SAPS 3 (17% for both scores). Mortality risk was associated with older age, more frequent comorbidities, severe clinical presentation and complications. The APACHE II, SAPS 3, SOFA and M-CARS had good discriminative ability in distinguishing deaths and survivors with poor calibration of risk scores predicting mortality.

Conclusion
In a recent contemporary cohort of patients admitted into the ICCU for a variety of acute and critical cardiovascular conditions, scoring systems used in general ICU had good discrimination for patients’ clinical severity and mortality. Available scores preserve powerful discrimination but the overestimation of mortality suggests the importance of specific tailored scores to improve risk assessment of patients admitted into ICCUs.