bluuebunny/crossref_metadata_2025_split huggingface dataset:
“The primacy of labor over profits”: Thomas Mahony, the Beet Field Workers of Colorado, and Visions for a Consumerist Democracy, 1902–1957
Authors: Cain Ellen 
Published: May 2024

Abstract
During the first half of the twentieth century, ethnic Mexican beet workers in Colorado endured a daunting array of challenges that included dismal housing, meager wages, and a family labor system that forced children as well as adults to labor relentless hours in the sugar-beet fields. In response to these conditions, Catholic reformer Thomas Mahony promoted a vision of the American economy in which marginalized populations like the beet laborers would take their rightful place as healthy consumers and effective family providers. His vision was shaped by the Catholic social justice movement of the Progressive Era, as well as by a career in agricultural consumerism. From 1910 to 1913, for example, he served as director of exhibits for the Chicago Land Show, a position that immersed him in a world that marketed farm lands as idealized consumer commodities while rendering invisible the struggles of propertyless farm workers. When Mahony began his reform career a decade later, he strove to do exactly the opposite: make beet field workers as visible as possible in his blueprint for a vigorous consumerist democracy. At the same time, however, Mahony’s intense fears of radicalism overshadowed his reform impulses, reflecting profound tensions within the Catholic reform ethos that shaped him: a yearning for spiritual and social regeneration in constant battle with a dread of social upheaval. Mahony’s story therefore helps to illuminate the considerable potential of twentieth-century religious reform, even as his obsessive fears highlight the perils of antiradicalism in the U.S. West.
Mechanical stretch preconditioned adipose‐derived stem cells elicit polarization of anti‐inflammatory M2‐like macrophages and improve chronic wound healing
Authors: He Jiahao , Shan Shengzhou , Jiang Taoran , Zhou Sizheng , Qin Jiaqi , Li Qingfeng , Yu Zheyuan , Cao Dejun , Fang Bin 
Published: May 2024

AbstractTransplantation of adipose‐derived stem cells (ASCs) is a promising option in the field of chronic wounds treatment. However, the effectiveness of ASCs therapies has been hampered by highly inflammatory environment in chronic wound areas. These problems could be partially circumvented using efficient approaches that boost the survival and anti‐inflammatory capacity of transplanted ASCs. Here, by application of mechanical stretch (MS), we show that ASCs exhibits increased survival and immunoregulatory properties in vitro. MS triggers the secretion of macrophage colony stimulating factor (M‐CSF) from ASCs, a chemokine that is linked to anti‐inflammatory M2‐like macrophages polarization. When the MS‐ASCs were transplanted to chronic wounds, the wound area yields significantly faster closure rate and lower inflammatory mediators, largely due to macrophages polarization driven by transplanted MS‐ASCs. Thus, our work shows that mechanical stretch can be harnessed to enhance ASCs transplantation efficiency in chronic wounds treatment.
Multifactoral immune modulation potentiates durable remission in multiple models of aggressive malignancy
Authors: Halpert Matthew M. , Burns Briana A. , Rosario Spencer R. , Withers Henry G. , Trivedi Akshar J. , Hofferek Colby J. , Gephart Benjamin D. , Wang Haotong , Vazquez‐Perez Jonathan , Amanya Sharon B. , Hyslop Sean T. , Yang Jianhua , Kemnade Jan O. , Sandulache Vlad C. , Konduri Vanaja , Decker William K. 
Published: May 2024

AbstractTumors typically lack canonical danger signals required to activate adaptive immunity and also frequently employ substantial immunomodulatory mechanisms that downregulate adaptive responses and contribute to escape from immune surveillance. Given the variety of mechanisms involved in shielding tumors from immune recognition, it is not surprising that single‐agent immunomodulatory approaches have been largely unsuccessful in generating durable antitumor responses. Here we report a unique combination of immunomodulatory and cytostatic agents that recondition the tumor microenvironment and eliminate complex and/or poor‐prognosis tumor types including the non‐immunogenic 4T‐1 model of TNBC, the aggressive MOC‐2 model of HNSCC, and the high‐risk MYCN‐amplified model of neuroblastoma. A course of therapy optimized for TNBC cured a majority of tumors in both ectopic and orthotopic settings and eliminated metastatic spread in all animals tested at the highest doses. Immune responses were transferable between therapeutic donor and naïve recipient through adoptive transfer, and a sizeable abscopal effect on distant, untreated lesions could be demonstrated experimentally. Similar results were observed in HNSCC and neuroblastoma models, with characteristic remodeling of the tumor microenvironment documented in all model systems. scRNA‐seq analysis implicated upregulation of innate immune responses and antigen presentation in tumor cells and the myeloid cell compartment as critical early events. This analysis also highlighted the potential importance of the autonomic nervous system in the governance of inflammatory processes. The data indicate that the targeting of multiple pathways and mechanisms of action can result in substantial synergistic antitumor effects and suggest follow‐up in the neoadjuvant setting may be warranted.
Creating an Assignment to Incorporate Antiracist Pedagogy Into an Undergraduate Introductory Nursing Course
Authors: Mangino Heather 
Published: May 2024

Abstract
Antiracist pedagogy was incorporated into an undergraduate introductory nursing course using National League for Nursing diversity and inclusion initiatives and academic nurse educator competencies as a framework. This article describes the reflective process and steps taken to select Taylor’s memoir, Reminiscences of My Life in Camp, as a required text for an introductory nursing course. By incorporating antiracism into an introductory nursing course, educators can assist novice nursing students from diverse groups to envision themselves as nurses, role model allyship for White students, and create a more inclusive teaching environment.
Transcriptional Profiling Underscores the Role of Preprocurement Allograft Metabolism and Innate Immune Status on Outcomes in Human Liver Transplantation
Authors: Kim Joohyun , Zimmermann Michael T. , Mathison Angela J. , Lomberk Gwen , Urrutia Raul , Hong Johnny C. 
Published: May 2024

Objective:
The adverse effects of ischemia-reperfusion injury (IRI) remain a principal barrier to a successful outcome after lifesaving orthotopic liver transplantation (OLT). Gene expression during different phases of IRI is dynamic and modified by individual exposures, making it attractive for identifying potential therapeutic targets for improving the number of suitable organs for transplantation and patient outcomes. However, data remain limited on the functional landscape of gene expression during liver graft IRI, spanning procurement to reperfusion and recovery. Therefore, we sought to characterize transcriptomic profiles of IRI during multiple phases in human OLT.

Methods:
We conducted clinical data analyses, histologic evaluation, and RNA sequencing of 17 consecutive human primary OLT. We performed liver allograft biopsies at 4 time points: baseline (B, before donor cross-clamp), at the end of cold ischemia (CI), during early reperfusion (ER, after revascularization), and during late reperfusion (LR). Data were generated and then recipients grouped by post-OLT outcomes categories: immediate allograft function (IAF; n = 11) versus early allograft dysfunction (EAD; n = 6) groups.

Results:
We observed that CI (vs B) modified a transcriptomic landscape enriched for a metabolic and immune process. Expression levels of hallmark inflammatory response genes were higher transitioning from CI to ER and decreased from ER to LR. IAF group predominantly showed higher bile and fatty acid metabolism activity during LR compared with EAD group, while EAD group maintained more immunomodulatory activities. Throughout all time points, EAD specimens exhibited decreased metabolic activity in both bile and fatty acid pathways.

Conclusions:
We report transcriptomic profiles of human liver allograft IRI from prepreservation in the donor to posttransplantation in the recipient. Immunomodulatory and metabolic landscapes across ER and LR phases were different between IAF and EAD allografts. Our study also highlights marker genes for these biological processes that we plan to explore as novel therapeutic targets or surrogate markers for severe allograft injury in clinical OLT.
The switch triggering the invasion process: Lipid metabolism in the metastasis of hepatocellular carcinoma
Authors: Zhang Jiaqian , Zhang Zhicheng , Wu Zhangfan , Wang Yufei , Zhang Zerui , Xia Limin 
Published: May 2024

Abstract
In humans, the liver is a central metabolic organ with a complex and unique histological microenvironment. Hepatocellular carcinoma (HCC), which is a highly aggressive disease with a poor prognosis, accounts for most cases of primary liver cancer. As an emerging hallmark of cancers, metabolic reprogramming acts as a runaway mechanism that disrupts homeostasis of the affected organs, including the liver. Specifically, rewiring of the liver metabolic microenvironment, including lipid metabolism, is driven by HCC cells, propelling the phenotypes of HCC cells, including dissemination, invasion, and even metastasis in return. The resulting formation of this vicious loop facilitates various malignant behaviors of HCC further. However, few articles have comprehensively summarized lipid reprogramming in HCC metastasis. Here, we have reviewed the general situation of the liver microenvironment and the physiological lipid metabolism in the liver, and highlighted the effects of different aspects of lipid metabolism on HCC metastasis to explore the underlying mechanisms. In addition, we have recapitulated promising therapeutic strategies targeting lipid metabolism and the effects of lipid metabolic reprogramming on the efficacy of HCC systematical therapy, aiming to offer new perspectives for targeted therapy.
DIAGNOSTIC YIELD OF AN INHERITED RETINAL DISEASE GENE PANEL IN RETINOPATHY OF UNKNOWN ORIGIN
Authors: Abramowicz Stéphane , Meunier Audrey , Postelmans Laurence , Caspers Laure , Corazza Francis , De Bruyne Marieke , Van de Sompele Stijn , De Baere Elfride , Leroy Bart P. , Willermain François , Draganova Dafina 
Published: May 2024

Purpose:
Evaluating the presence of class 3, 4, and 5 genetic variants in inherited retinal disease (IRD) genes in patients with retinopathy of unknown origin (RUO).

Methods:
Multicentric retrospective study of RUO cases diagnosed between January 2012 and February 2022. General and ophthalmologic history, complete ophthalmologic examination, antiretinal antibodies, and IRD gene panel results were analyzed in every patient. Four RUO categories were defined: nonparaneoplastic autoimmune retinopathy, unilateral pigmentary retinopathy, asymmetrical pigmentary retinopathy, and acute zonal occult outer retinopathy.

Results:
The authors included 12 patients (9 females) across these four RUO categories. Mean age at inclusion was 45.6 years (20–68 years). Seven patients demonstrated class 3 variants in IRD genes. Of these, two also demonstrated class 5 variants in other IRD genes. The remaining five patients had negative panel results. IRD gene panel analysis allowed diagnosis refinement in 1 (8.3%) nonparaneoplastic autoimmune retinopathy patient in the RUO cohort. When considering the nonparaneoplastic autoimmune retinopathy subpopulation only, a higher diagnostic yield of 20% (1/5 patients) was achieved.

Conclusion:
Every suspected nonparaneoplastic autoimmune retinopathy patient should benefit from gene panel testing to not overlook undiagnosed IRDs. By contrast, unilateral pigmentary retinopathy, asymmetrical pigmentary retinopathy, and acute zonal occult outer retinopathy subpopulations did not benefit from genetic testing in this study.
Blink Lagophthalmos in Graves Orbitopathy
Authors: Guimarães Juliana A. , Garcia Denny M. , Cruz Antonio Augusto Velasco e 
Published: May 2024

Purpose:
To investigate the relationship between the kinematics of spontaneous blinks and the anterior area of the levator palpebrae superioris muscle in patients with Graves orbitopathy (GO).

Methods:
This is a case-control study. The authors measured the margin reflex distance of the upper eyelid (margin reflex distance 1), the kinematics of spontaneous blinks, and the anterior area of levator palpebrae superioris muscle in CT coronal scans of patients with Graves upper eyelid retraction (GO) and a control group. The eye with the greatest margin reflex distance 1 was selected for analysis in each group.

Results:
A total of 68 participants were included, with 36 in the GO group and 32 in the control group. In the GO group, the mean margin reflex distance 1 measured 6.5 mm, while in the control group, it was 3.9 mm. Almost all parameters related to the closing phase of spontaneous blinking activity, including amplitude, velocity, blinking rate, and interblink time, did not differ between the two groups. However, the effectiveness of the blink’s amplitude (ratio of blink amplitude to margin reflex distance 1) and the main sequence (relationship between amplitude and velocity) were significantly reduced in the GO group compared with the control group. The area of the levator palpebrae superioris muscle was significantly larger in GO than in controls, with 71.4% of patients’ muscles outside of the maximum range of the controls.

Conclusions:
In patients with GO, there is a reduction in blinking effectiveness, also known as blink lagophthalmos, which is a factor in the common occurrence of ocular surface symptoms. The increase in velocity with amplitude is also reduced in GO.
Clinical outcomes of the light-adjustable lens in eyes with a history of prior corneal refractive surgery
Authors: Jones Marlee , Terveen Daniel C. , Berdahl John P. , Thompson Vance , Kramer Brent A. , Ferguson Tanner J. 
Published: May 2024

Purpose:
To evaluate the visual and refractive outcomes in eyes with a history of laser corneal refractive surgery implanted with the second-generation light-adjustable lens (LAL).

Setting:
Private practice, Sioux Falls, South Dakota.

Design:
Retrospective, consecutive case series.

Methods:
Eyes with a history of prior corneal refractive surgery that underwent cataract surgery with implantation of the LAL and were targeted for plano were included. Data on the type and number of prior refractive surgeries were collected, in addition to the timing and number of postoperative adjustments. The primary outcome measures were uncorrected distance visual acuity (UDVA), corrected distance visual acuity, and the percentage (%) of eyes within ±0.25 diopter (D), ±0.50 D, and ±1.00 D of their refractive target.

Results:
76 eyes from 70 patients were included. A total of 45 eyes with a history of 1 prior refractive surgery and 31 eyes with a history of ≥2 refractive surgeries were included. 74% (n = 56) of all eyes achieved UDVA of 20/20 or better, 88% (n = 67) achieved 20/25 UDVA or better, and 93% (n = 71) were correctable to 20/20 or better postoperatively. For refractive outcomes, 66% of eyes (n = 50) were within ±0.25 D and 86% (n = 65) were within ±0.50 D of refractive target.

Conclusions:
Patients with a history of laser corneal refractive surgery achieved favorable visual and refractive outcomes with the LAL. This intraocular lens (IOL), which affords postoperative adjustability, is a promising option for patients with a history of corneal refractive surgery who maintain high expectations for functional uncorrected acuity after cataract surgery.
The Development of an Opioid Misuse Training Program for Physical Therapists: A Learning Community Approach
Authors: Magel John , Siantz Elizabeth , Blosser Priscilla , Fritz Julie M. , Gordon Adam J. 
Published: May 2024

Introduction.
Musculoskeletal pain and opioid misuse frequently co-occur.

Review of the Literature.
The US Preventive Services Task Force calls for all health care providers to be trained to screen for misuse and/or opioid use disorder. The purpose of this study was to develop and implement an opioid misuse training program that could be used by physical therapists.

Subjects.
Thirteen practicing physical therapists were invited to participate in a curriculum development project.

Methods.
Using the Curriculum Framework, a collaborative learning approach was used to develop an opioid misuse training program and training manual for physical therapists. Four training sessions were provided virtually every 2 weeks. Topics included an introduction to the opioid crisis, screening, assessing, and communicating with patients and with the health care team about opioid misuse. Each didactic session was followed by a participant feedback session where participants provided recommendations on improving the training content and their impressions on the barriers and facilitators to incorporating the training into practice. A companion training manual was created and sent to participants for comment. Participants were asked over email to describe whether and how they incorporated training materials into clinical practice during the training curriculum.

Results.
All participants attended sessions 1–3. Twelve (92.3%) attended the fourth session. Based on the participants' feedback, training sessions were edited, and a companion training manual was finalized and distributed to each participant. After the fourth session, 9 participants (69.2%) reported using what they learned in the training. During the participant feedback sessions, participants regarded the training as important. Some participants expressed barriers to discussing opioids with patients and concerns about whether the training was within physical therapists' scope of practice.

Discussion and Conclusion.
An iteratively developed training program for physical therapists to address opioid misuse was acceptable, feasible, and provided immediate practice change by most participants.
Impact of prior coronary artery bypass grafting and coronary lesion complexity on outcomes of transcatheter aortic valve replacement for severe aortic stenosis
Authors: Yamashita Yoshiyuki , Sicouri Serge , Baudo Massimo , Dokollari Aleksander , Rodriguez Roberto , Gnall Eric M. , Coady Paul M. , Jarrett Harish , Abramson Sandra V. , Hawthorne Katie M. , Goldman Scott M. , Gray William A. , Ramlawi Basel 
Published: May 2024

Objective
To investigate the impact of prior coronary artery bypass grafting (CABG) and coronary lesion complexity on transcatheter aortic valve replacement (TAVR) outcomes for aortic stenosis.

Methods
Clinical outcomes of TAVR were retrospectively compared between patients with and without prior CABG, and between patients with prior CABG and without coronary artery disease (CAD). The impact of the CABG SYNTAX score was also evaluated in patients with prior CABG.

Results
The study included 1042 patients with a median age and follow-up of 82 years and 25 (range: 0–72) months, respectively. Of these, 175 patients had a history of CABG, while 401 were free of CAD. Patients with prior CABG were more likely to be male and had higher rates of diabetes, peripheral artery disease and atrial fibrillation compared with patients without prior CABG. After 2 : 1 propensity score matching, all-cause mortality (P = 0.17) and the composite of all-cause mortality, stroke and coronary intervention (P = 0.16) were similar between patients with (n = 166) and without (n = 304) prior CABG. A 1 : 1 propensity score-matched analysis, however, showed lower rates of all-cause mortality (P = 0.04) and the composite outcome (P = 0.04) in patients with prior CABG (n = 134) compared with patients without CAD (n = 134). The median CABG SYNTAX score was 16 (interquartile range: 9.0–23), which was not associated with better/worse clinical outcomes in patients with prior CABG.

Conclusion
Prior CABG may positively affect mid-term TAVR outcomes for aortic stenosis compared with no CAD when adjusted for other comorbidities. The CABG SYNTAX score did not influence the prognosis after TAVR.
Teaching Evidence-Based Practice Competencies to Meet Professional Practice Needs
Authors: Bourgault Annette M. , Penoyer Daleen , Conner Norma E. 
Published: May 2024

Background:
Evidence-based practice (EBP) is a major concept threaded throughout nursing education, yet competencies are not clearly identified in The Essentials.

Purpose:
Nurse leaders‘EBP competency expectations for professional practice were explored to inform competency-based education for students and practicing nurses. A secondary aim explored potential effects of misinformation on EBP.

Methods:
Descriptive qualitative inquiry was performed with a focus group of 6 clinical nurse leaders.

Results:
EBP expectations were identified, discriminating between novice entry level and advanced-level nurses. Participants emphasized asking questions, linking evidence to practice, and acknowledging that evidence changes over time. All advanced-level nurses were expected to apply, lead, and teach EBP. Post pandemic, nurses need to reclaim evidence-based practices, critically appraise evidence, and educate patients and families to address misinformation.

Conclusions:
Information learned will inform competency-based EBP education for students and nurses in academic and clinical settings.
Has Propranolol Eradicated the Need for Surgery in the Management of Infantile Hemangioma?
Authors: Coulie Julien , Dekeuleneer Valérie , Gerdom Alexander , Roggen Mieke , Bataille Anne-Christine , Moniotte Stéphane , Coyette Maude , De Roo An-Katrien , Boon Laurence M. 
Published: May 2024

Background:
The authors assessed the impact of propranolol as the first-line treatment of infantile hemangioma (IH) on the need for surgery in the management of IH.

Methods:
In this retrospective study, 420 patients with IH referred to a multidisciplinary center between January of 2005 and August of 2014 were included. Clinical data, including sex; age at first consultation and at treatment initiation; location, size, number, aspect, and complications of IH; and type of treatment were collected. Statistical analyses were conducted considering each patient and each tumor independently.

Results:
A total of 625 IHs (420 patients) were reviewed; 113 patients had more than 1 IH (26.91%). Median age at first consultation was 7 months. Overall, 243 patients were treated (57.86%) using surgery (n = 128 patients, 141 IHs), propranolol (n = 79 patients, 89 IHs), corticosteroids (n = 51 patients, 56 IHs), or laser (n = 34 patients, 36 IHs). Propranolol was effective in all but 2 infants with IH. Seven of 79 patients (8.86%) initially treated with propranolol still required surgery, in contrast to 18 of 51 patients (35.29%) initially treated with corticosteroids and 103 of 290 patients (35.51%) with no medical treatment. Since the availability of propranolol, patients were less likely to undergo surgery (48 versus 80 patients; P < 0.001). This demonstrated that the use of propranolol reduced the need for surgery (P < 0.001; OR, 0.177; 95% CI, 0.079 to 0.396).

Conclusions:
Propranolol dramatically reduced the need for surgery, regarding indications and number of patients. Surgical correction remains important for sequelae management, nonresponders, or strawberry-like IH.

CLINICAL QUESTION/LEVEL OF EVIDENCE:
Risk, III.