bluuebunny/crossref_metadata_2025_split huggingface dataset:
Barriers and enablers to people‐centred viral hepatitis care in Vietnam and the Philippines: Results of a patient journey mapping study
Authors: Holt Bethany , Mendoza Jhaki , Nguyen Hoang , Doan Duong , Nguyen Vy H. , Cabauatan Daniel Joy , Duy Lam Dam , Fernandez Martin , Gaspar Manu , Hamoy Geohari , Manlutac Joseph Michael D. , Mehtsun Sinit , Mercado Timothy Bill , Neo Boon‐Leong , Le Bao Ngoc , Nguyen Hoa , Nguyen Huyen Thu , Nguyen Yen , Pham Thuy , Pollack Todd , Rombaoa Mary Cris , Thai Pham , Thu Tran Khanh , Truong Pham Xuan , Vu Dung , Ong Janus , Duong David 
Published: April 2024

AbstractIn Vietnam and the Philippines, viral hepatitis is the leading cause of cirrhosis and liver cancer. This study aims to understand the barriers and enablers of people receiving care for hepatitis B and C to support both countries' efforts to eliminate viral hepatitis as a public health threat by 2030. Retrospective, semi‐structured interviews were conducted with a purposive, quota‐based sample of 63 people living with hepatitis B or C in one province of Vietnam and one region of the Philippines. A rapid deductive approach to thematic analysis produced key findings among the three phases of care: (1) pre‐awareness and testing, (2) linkage and treatment initiation and (3) ongoing treatment and recovery. The research found that participants followed five typical journeys, from a variety of entry points. Barriers during the pre‐awareness and testing phase included limited awareness about hepatitis and its management, stigma and psychological impacts. Enablers included being familiar with the health system and/or patients benefiting from social connections within the health systems. During the linkage and treatment initiation phase, barriers included difficult physical access, complex navigation and inadequate counselling. In this phase, family support emerged as a critical enabler. During the ongoing treatment and recovery phase, the cost of care and socially and culturally informed perceptions of the disease and medication use were both barriers and enablers. Exploring peoples' journeys with hepatitis B and C in Vietnam and the Philippines revealed many similarities despite the different cultural and health system contexts. Insights from this study may help generate a contextualized, people‐centred evidence base to inform the design and improvement of primary care services for hepatitis in both research sites.
Virtual trial assembly of large steel members with bolted connections based on multiscale point cloud fusion
Authors: Zhang Zeyu , Liang Dong , Huang Haibin , Sun Lu 
Published: April 2024

AbstractVirtual trial assembly (VTA) using 3D laser scanning as the digital carrier can overcome the shortcomings of time‐consuming and costly physical preassembly. However, its application in large steel structures with bolted connections remains limited. First, this study introduces a novel approach for acquiring multiscale point cloud data of large steel members using terrestrial laser scanners (TLSs) and hand‐held scanner (HHS). This approach considers both the global data and the local details of the steel members. Additionally, a precise registration method based on magnetic 3D targets is proposed for multiscale point clouds, which enables the registration accuracy of multisource point clouds to reach submillimeter precision. Subsequently, a novel algorithm for feature point screening is introduced, which utilizes a dichotomous point cloud grid approach to identify and extract a significant quantity of bolt holes effectively. This approach enables fully automated and fast extraction of the point cloud on the cylindrical inner surface of the holes. Finally, the bounding box and Procrustes analysis approach are employed to perform VTA using the point cloud of the cylindrical bolt holes as the assembled features. The accuracy and feasibility of the above method are verified by a down‐scale modeling experiment and project test, which provide technical support for the VTA of large steel truss structures.
Leucine‐rich alpha‐2‐glycoprotein 1 affects bone destruction via IL‐6 in mouse periodontitis model
Authors: Ouhara Kazuhisa , Takemura Tasuku , Taniguchi Yuri , Fujimori Ryousuke , Tamura Tetsuya , Akane Yuki , Matsuda Shinji , Hamamoto Yuta , Shintani Tomoaki , Kajiya Mikihito , Munenaga Syuichi , Iwata Tomoyuki , Fujita Tsuyoshi , Mizuno Noriyoshi 
Published: April 2024

AbstractObjectiveTo investigate the production of leucine‐rich α‐2‐glycoprotein‐1 (LRG1) in periodontitis patients and its effectiveness as a new diagnostic marker for periodontitis.Subjects and MethodsIn vitro experiments were conducted to analyze LRG1 mRNA expression in human gingival epithelial cells and fibroblasts via quantitative real‐time PCR. In vivo experiments were conducted to analyze LRG1 localization in periodontitis patients. The correlation between the serum LRG1 levels and alveolar bone resorption in the mouse periodontitis model was also investigated.ResultsA positive correlation existed between the periodontal inflamed surface area and serum LRG1 levels (Spearman's rank correlation coefficient: 0.60). LRG1 mRNA expression in human gingival epithelial cells and fibroblasts was upregulated by Porphyromonas gingivalis stimulation or tumor necrosis factor‐α stimulation. Interleukin‐6 in human gingival epithelial cells and fibroblasts induced the production of LRG1 and transforming growth factor‐β. LRG1 levels in the periodontal tissue and serum in the periodontitis model were higher than those in control mice. LRG1 local administration resulted in alveolar bone resorption, whereas the administration of interleukin‐6R antibody inhibited bone resorption.ConclusionsLRG1 levels in serum and periodontal tissue are upregulated in periodontitis and are implicated in periodontal tissue destruction through interleukin‐6 production.
Xanthan‐based chlorhexidine gel effects in non‐surgical periodontal therapy? A meta‐analysis
Authors: Mensi Magda , Palazzolo Antonino , Garzetti Gianluca , Lops Diego , Calza Stefano , Rota Matteo 
Published: April 2024

AbstractObjectiveTo carry out a systematic review and meta‐analysis of randomized controlled clinical trials (RCTs) and controlled clinical trials (CCTs) comparing scaling and root planing (SRP) or placebo with subgingival application of xanthan‐based CHX (chlorhexidine) gel as adjunct to SRP.Materials and MethodsThe literature search was carried out in PubMed/MEDLINE, EMBASE, and SCOPUS; primary outcomes were probing pocket depth (PPD) reduction and gain in clinical attachment level (CAL).ResultsOverall, 15 studies were included. Three studies were judged to be at moderate risk of bias while the remaining 12 were rated at high risk of bias. A significant improvement in PPD reduction (standardized mean difference, SMD, 0.87, 95% CI, 0.41–1.34) and CAL gain (SMD = 0.84, 95% CI, 0.36–1.33) emerged for the SRP + CXH gel compared to the SRP alone group, in the presence of significant high heterogeneity among the studies.ConclusionsOur systematic review and meta‐analysis showed that xanthan‐based chlorhexidine gel as adjunct to non‐surgical periodontal therapy gives benefit in terms of PPD reduction and CAL gain as compared to non‐surgical periodontal therapy only. Since there was high heterogeneity among studies and the quality of the evidence is low, further studies characterized by a better methodology, adequate sample size and longer follow‐up are warranted in the next future.RegistrationThe protocol of this scoping review was registered in the International Prospective Register of Systematic Reviews (https://www.crd.york.ac.uk/PROSPERO) with ID: CRD42023391589.
Dendritic cell subpopulations in carcinoma ex‐pleomorphic adenoma: A multicenter study
Authors: Machado Bárbara Azevedo , Gama‐Cuellar Ana Guadalupe , Scarini João Figueira , Díaz Katya Pulido , Mariano Fernanda Viviane , Albuquerque‐Junior Ricardo Luiz Cavalcanti , Gondak Rogério 
Published: April 2024

AbstractObjectiveCarcinoma ex‐pleomorphic adenoma (CEXPA) represents a malignant transformation from a recurrent or primary pleomorphic adenoma (PA), and the immune response may be essential in this process. Therefore, in this study, we aimed to identify and quantify subpopulations of dendritic cells (DCs) in CEXPA, residual PA in CEXPA (rPA), and PA.Materials and MethodsA multicenter study was performed collecting salivary gland tumor (SGT) samples from three Oral and Maxillofacial Pathology Centers. A tissue microarray containing 41 samples of CEXPA and 22 samples of PA was included in this study and submitted to immunohistochemical reactions against CD1a, CD83, CD207, and Ki67 antibodies.ResultsBoth PA and rPA showed a higher quantification of CD207+ and CD83+ cells when compared to CEXPA (p < 0.001 and p < 0.01, respectively). There was also a difference when comparing the cell proliferation index between PA/rPA and CEXPA using the Ki‐67 marker (p = 0.043). However, there was no difference in the DC population regarding clinical parameters such as sex, anatomical location, size, and metastases (p > 0.06).ConclusionsImmunohistochemical profile of DC subpopulations and cell proliferation biomarkers in SGTs can contribute as an important tool in the differentiation of benign and malignant tumors or detection of initial areas with malignant transformation.
Pediatric anesthesia in Australia and New Zealand and health inequity among First Nations and Māori children
Authors: Waugh Edith , Thomas Jane , Anderson Brian J. , Lee‐Archer Paul 
Published: April 2024

AbstractAustralia and New Zealand are two countries in the Southern Pacific region. They share many pediatric anesthesia similarities in terms of medical organizational systems, education, training, and research, however there are important differences between the two nations in relation to geography, the First Nations populations and the history of colonization. While the standards for pediatric anesthesia and the specialty training requirements are set by the Australian and New Zealand College of Anesthetists and the Society for Pediatric Anesthesia in New Zealand and Australia, colonization has created distinct challenges that each nation now faces in order to improve the anesthetic care of its pediatric population. Australia generally has a high standard of living and good access to health care; disparities exist for First Nations People and for those living in rural or remote areas. Two influences have shaped training within New Zealand over the past 40 years; establishment of a national children's hospital in 1990 and, more importantly, acknowledgement that the First Nations people of New Zealand (Māori) have suffered because of failure to recognize their rights consequent to establishing a partnership treaty between Māori and the British Crown in 1840. Health inequities among Māori in New Zealand and First Nations People in Australia have implications for the health system, culturally appropriate approaches to treatment, and the importance of having an appreciation of First Nations people's history and culture, language, family structure, and cultural safety. Trainees in both countries need to be adequately supported in these areas in order for the sub‐specialty of pediatric anesthesia to develop further and improve the anesthetic and surgical outcomes of our children.
Ancient bayberry increased stress resistance by enriching tissue‐specific microbiome and metabolites
Authors: Li Gang , Wang Zhenshuo , Ren Haiying , Qi Xingjiang , Han Hao , Ding Xiangyang , Sun Li , Hafeez Rahila , Wang Qi , Li Bin 
Published: April 2024

AbstractThe ancient bayberry demonstrates superior resistance to both biotic and abiotic stresses compared to cultivated bayberry, yet the underlying mechanisms remain largely unexplored. This study investigates whether long‐term bayberry cultivation enhances stress resistance through modulation of tissue‐specific microbes and metabolites. Employing microbiome amplicon sequencing alongside untargeted mass spectrometry analysis, we scrutinize the role of endosphere and rhizosphere microbial communities and metabolites in shaping the differential resistance observed between ancient and cultivated bayberry trees. Our findings highlight the presence of core microbiome and metabolites across various bayberry tissues, suggesting that the heightened resistance of ancient bayberry may stem from alterations in rhizosphere and endosphere microbial communities and secondary metabolites. Specifically, enrichment of Bacillus in roots and stems, Pseudomonas in leaves, and Mortierella in rhizosphere soil of ancient bayberry was noted. Furthermore, correlation analysis underscores the significance of enriched microbial species in enhancing ancient bayberry's resistance to stresses, with elevated levels of resistance‐associated metabolites such as beta‐myrcene, benzothiazole, L‐glutamic acid, and gamma‐aminobutyric acid identified through GC–MS metabolomics analysis. The beneficial role of these resistance‐associated metabolites was further elucidated through assessment of their promotive and allelopathic effects, as well as their phytostatic and antioxidant functions in lettuce plants. Ultimately, our study delves into the intrinsic reasons behind the greater resistance of ancient bayberry to biotic and abiotic stresses by evaluating the impact of long‐term planting on the microbial community and metabolites in the bayberry endosphere and rhizosphere, shedding light on the complex dynamics of host‐microbial interactions.
“Maybe if we weren't in the pandemic, I would have reconsidered”: Experiences of abortion care‐seeking during the COVID‐19 pandemic in Maryland
Authors: Dozier Jessica L. , Burke Anne E. , McMahon Hayley V. , Berger Blair O. , Quasebarth Madeline , Sufrin Carolyn , Bell Suzanne O. 
Published: April 2024

AbstractObjectiveTo understand the COVID‐19 pandemic's impact on abortion care‐seeking in Maryland, a state with Medicaid coverage for abortion, high service availability, and laws supporting abortion rights.MethodsWe conducted semi‐structured telephone interviews with 15 women who had an abortion between January 2021 and March 2022 at a hospital‐based clinic in a mid‐sized Maryland city. We purposively recruited participants with varied pandemic financial impacts. Interview questions prompted participants to reflect on how the pandemic affected their lives, pregnancy decisions, and experiences seeking abortion care. We analyzed our data for themes.ResultsAll participants had some insurance coverage for their abortion; over half paid using Medicaid. Many participants experienced pandemic financial hardship, with several reporting job, food, and housing insecurity as circumstances influencing their decision to have an abortion. Most women who self‐reported minimal financial hardship caused by the pandemic indicated they sought an abortion for reasons unrelated to COVID‐19. In contrast, women with economic hardship viewed their pregnancies as unsupportable due to COVID‐19 exacerbating financial instability, even when they desired to continue the pregnancy. All participants expressed that having an abortion was the best decision for their lives. Yet, when making decisions about their pregnancy, the most financially disadvantaged women weighed their desires against the pandemic's constraints on their reproductive self‐determination.ConclusionsThe pandemic changed abortion care‐seeking circumstances even in a setting with minimal access barriers. Financial hardship influenced some women to have an abortion for a pregnancy that—while unplanned—they may have preferred to continue.
Lymphangioleiomyomatosis as a potent lung cancer risk factor: Insights from a Japanese large cohort study
Authors: Torasawa Masahiro , Shukuya Takehito , Uemura Kohei , Hayashi Takuo , Ueno Toshihide , Kohsaka Shinji , Masui Yoshihiro , Shirai Yukina , Okura Makiko , Asao Tetsuhiko , Mitsuishi Yoichiro , Shimada Naoko , Takahashi Fumiyuki , Takamochi Kazuya , Suzuki Kenji , Takahashi Kazuhisa , Seyama Kuniaki 
Published: April 2024

AbstractBackground and ObjectiveLymphangioleiomyomatosis (LAM) is a rare neoplastic disease associated with the functional tumour suppressor genes TSC1 and TSC2 and causes structural destruction in the lungs, which could potentially increase the risk of lung cancer. However, this relationship remains unclear because of the rarity of the disease.MethodsWe investigated the relative risk of developing lung cancer among patients diagnosed with LAM between 2001 and 2022 at a single high‐volume centre in Japan, using data from the Japanese Cancer Registry as the reference population. Next‐generation sequencing (NGS) was performed in cases where tumour samples were available.ResultsAmong 642 patients diagnosed with LAM (sporadic LAM, n = 557; tuberous sclerosis complex‐LAM, n = 80; unclassified, n = 5), 13 (2.2%) were diagnosed with lung cancer during a median follow‐up period of 5.13 years. All patients were female, 61.5% were never smokers, and the median age at lung cancer diagnosis was 53 years. Eight patients developed lung cancer after LAM diagnosis. The estimated incidence of lung cancer was 301.4 cases per 100,000 person‐years, and the standardized incidence ratio was 13.6 (95% confidence interval, 6.2–21.0; p = 0.0008). Actionable genetic alterations were identified in 38.5% of the patients (EGFR: 3, ALK: 1 and ERBB2: 1). No findings suggested loss of TSC gene function in the two patients analysed by NGS.ConclusionOur study revealed that patients diagnosed with LAM had a significantly increased risk of lung cancer. Further research is warranted to clarify the carcinogenesis of lung cancer in patients with LAM.image
The link between organizational choice and global input sourcing under sequential production
Authors: Karabay Bilgehan 
Published: April 2024

AbstractThis article analyzes the ways heterogenous firms procure their inputs in the presence of relationship‐specific investments and incomplete contracts. We first consider a closed economy in which firms decide how to structure their organization. Production is sequential and inputs (upstream and downstream) are sourced in the same order as production. While our closed‐economy setup is analogous to Antràs and Chor (Econometrica, 2013), there are two distinct features: (1) The reward to each supplier is determined through bargaining over the full revenue of the firm (as opposed to marginal contribution of the supplier), and (2) The reward structure combined with our sequential bargaining protocol gives rise to linkages across suppliers. The analysis in Antràs and Chor (Econometrica, 2013) identifies a mechanism in which upstream organizational decisions have spillover effects on downstream suppliers' investment incentives. Thanks to our novel features, we identify another mechanism: the spillover effects of downstream organizational decisions on the investment incentive of upstream suppliers. Next, we consider an open economy in which firms not only make organizational decisions but also determine where to source their inputs. We show that these decisions are connected between sequential production stages such that the sourcing location of the upstream input may affect the organizational choice in the downstream stage. We then examine how within sectoral heterogeneity and variations in industry characteristics influence the relative prevalence of firms that choose to form different organizational structures.
The politics of tariff cooperation in the presence of trade costs
Authors: Susa Taiki , Tsubuku Masafumi 
Published: April 2024

AbstractThis study explores how income inequality among individuals in each country and trade costs depicting geographic distance between countries impact economic welfare and regime choice under representative democracy, comparing three trading regimes: most favored nation, customs union, and free trade agreement. We examine two cases: one in which trade costs are incurred symmetrically among all countries, and the other in which no trade costs are incurred among the potential member countries, but only between them and nonmembers. In each case, we identify the political feasibility of each regime as well as the impact on the average welfare levels.
Clinical and molecular significance of flow cytometric analysis for reactive oxygen species production and residual p67phox expression in p67phox‐deficient chronic granulomatous disease
Authors: Miyazawa Hanae , Muraoka Masahiro , Matsuda Yusuke , Toma Tomoko , Morio Tomohiro , Shigemura Tomonari , Haraguchi Kohei , Matsubayashi Tadashi , Kawai Toshinao , Shirai Yuya , Wada Taizo 
Published: April 2024

AbstractChronic granulomatous disease (CGD) is a primary immunodeficiency disease caused by molecular defects in nicotinamide adenine dinucleotide phosphate (NADPH) oxidase. p67phox‐CGD is an autosomal recessive CGD, which is caused by a defect in the cytosolic components of NADPH oxidase, p67phox, encoded by NCF2. We previously established a flow cytometric analysis for p67phox expression, which allows accurate assessment of residual protein expression in p67phox‐CGD. We evaluated the correlation between oxidase function and p67phox expression, and assessed the relevancy to genotypes and clinical phenotypes in 11 patients with p67phox‐CGD. Reactive oxygen species (ROS) production by granulocytes was evaluated using dihydrorhodamine‐1,2,3 (DHR) assays. p67phox expression was evaluated in the monocyte population. DHR activity and p67phox expression were significantly correlated (r = 0.718, p < 0.0162). Additionally, DHR activity and p67phox expression were significantly higher in patients carrying one missense variant in combination with one nonsense or frameshift variant in the NCF2 gene than in patients with only null variants. The available clinical parameters of our patients (i.e., age at disease onset, number of infectious episodes, and each infection complication) were not linked with DHR activity or p67phox expression levels. In summary, our flow cytometric analysis revealed a significant correlation between residual ROS production and p67phox expression. More deleterious NCF2 genotypes were associated with lower levels of DHR activity and p67phox expression. DHR assays and protein expression analysis by using flow cytometry may be relevant strategies for predicting the genotypes of p67phox‐CGD.
Walking an extra mile: Determinants of organizational citizenship behavior—An exploratory study in faith‐based organizations
Authors: Jose Jerin , Chully Arun Antony , Thomas Nobin 
Published: April 2024

AbstractObjectiveOur study is intended to explore the factors that promote organizational citizenship behaviors (OCB) in faith‐based organizations, which has the potential to extend the scholarly conversation around a previously unexplored context.MethodsOur study used a purposive, homogeneous sampling technique in selecting the participants. We interviewed 30 employees who have at least 5 years of experience in faith‐based organizations. We conducted detailed interviews and subsequent analysis involved a rigorous six‐step thematic analysis process to better understand the phenomena being studied.ResultsOur study revealed the significance of OCB in faith‐based organizations and further elucidated those factors that determine the display of OCBs. Our findings have the power to enhance the existing comprehension of OCBs in different environments, specifically those present in faith‐based organizations. Our study broadens our conceptual understanding of OCB in faith‐based organizations by adding one more dimension to the existing framework of P. MPodsakoff et al. (1990).ConclusionOur findings have important implications for organizational scholars in faith‐based organizations. Our new conceptual framework offers insights into the distinct characteristics of OCBs in faith‐based organizations and suggests directions for future scholars to engage with OCBs from different contexts.