bluuebunny/crossref_metadata_2025_split huggingface dataset:
Consequences of family disruption on children’s educational outcomes in Norway
Authors: Steele Fiona , Sigle-Rushton Wendy , Kravdal Øystein 
Published: August 2009

AbstractUsing high-quality data from Norwegian population registers, we examine the relationship between family disruption and children’s educational outcomes. We distinguish between disruptions caused by parental divorce and paternal death and, using a simultaneous equation model, pay particular attention to selection bias in the effect of divorce. We also allow for the possibility that disruption may have different effects at different stages of a child’s educational career. Our results suggest that selection on time-invariant maternal characteristics is important and works to overstate the effects of divorce on a child’s chances of continuing in education. Nevertheless, the experience of marital breakdown during childhood is associated with lower levels of education, and the effect weakens with the child’s age at disruption. The effects of divorce are most pronounced for the transitions during or just beyond the high school level. In models that do not allow for selection, children who experienced a father’s death appear less disadvantaged than children whose parents divorced. After we control for selection, however, differences in the educational qualifications of children from divorced and bereaved families narrow substantially and, at mean ages of divorce, are almost non-existent.
Do immigrants work in riskier jobs?
Authors: Orrenius Pia M. , Zavodny Madeline 
Published: August 2009

Abstract
Recent media and government reports suggest that immigrants are more likely to hold jobs with poor working conditions than U.S.-born workers, perhaps because immigrants work in jobs that “ natives don’t want.” Despite this widespread view, earlier studies have not found immigrants to be in riskier jobs than natives. This study combines individual-level data from the 2003-2005 American Community Survey with Bureau of Labor Statistics data on work-related injuries and fatalities to take a fresh look at whether foreign-born workers are employed in more dangerous jobs. The results indicate that immigrants are in fact more likely to work in risky jobs than U.S.-born workers, partly due to differences in average characteristics, such as immigrants’ lower English-language ability and educational attainment.
Investigating the mechanism of marital mortality reduction: The transition to widowhood and quality of health care
Authors: Jin Lei , Chrisatakis Nicholas A. 
Published: August 2009

Abstract
While it is well known that the widowed suffer increased mortality risks, the mechanism of this survival disadvantage is still under investigation. In this article, we examine the quality of health care as a possible link between widowhood and mortality using a unique data set of 475,313 elderly couples who were followed up for up to nine years. We address whether the transition to widowhood affects the quality of care that individuals receive and explore the extent to which these changes mediate the elevated mortality hazard for the widowed. We analyze six established measures of quality of health care in a fixed-effect framework to account for unobserved heterogeneity. Caregiving and acute bereavement during the transition to widowhood appear to distract individuals from taking care of their own health care needs in the short run. However, being widowed does not have long-term detrimental effects on individuals’ ability to sustain contact with the formal medical system. Moreover, the short-run disruption does not mediate the widowhood effect on mortality. Nevertheless, long after spousal death, men suffer from a decline in the quality of informal care, coordination between formal and informal care, and the ability to advocate and communicate in formal medical settings. These findings illustrate women’s centrality in the household production of health and identify important points of intervention in optimizing men’s adjustment to widowhood.
Change in disability-free life expectancy for Americans 70 years old and older
Authors: Crimmins Eileen M. , Hayward Mark D. , Hagedorn Aaron , Saito Yasuhiko , Brouard Nicolas 
Published: August 2009

Abstract
In this article, we examine changes in life expectancy free of disability using longitudinal data collected from 1984 through 2000 from two cohorts who composed the Longitudinal Studies of Aging I and II. Life expectancies with and without ADL and/or IADL disability are calculated using a Markov-based multistate life table approach. At age 70, disability-free life expectancy increased over a 10-year period by 0.6 of a year in the later cohort, which was the same as the increase in total life expectancy, both increases marginally statistically significant. The average length of expected life with IADL and ADL disability did not change. Changes in disability-free life expectancy resulted from decreases in disability incidence and increases in the incidence of recovery from disability across the two survey cohorts. Age-specific mortality among the ADL disabled declined significantly in the later cohort after age 80. Mortality for the IADL disabled and the nondisabled did not change significantly. Those with ADL disability at age 70 experienced substantial increases in both total life expectancy and disability-free life expectancy. These results indicate the importance of efforts both to prevent and delay disability and to promote recovery from disability for increasing life expectancy without disability. Results also indicate that while reductions in incidence and increases in recovery work to decrease population prevalence of disability, declining mortality among the disabled has been a force toward increasing disability prevalence.
On compact holomorphically pseudosymmetric Kählerian manifolds
Authors: Olszak Zbigniew 
Published: August 2009

Abstract
For compact Kählerian manifolds, the holomorphic pseudosymmetry reduces to the local symmetry if additionally the scalar curvature is constant and the structure function is non-negative. Similarly, the holomorphic Ricci-pseudosymmetry reduces to the Ricci-symmetry under these additional assumptions. We construct examples of non-compact essentially holomorphically pseudosymmetric Kählerian manifolds. These examples show that the compactness assumption cannot be omitted in the above stated theorem. Recently, the first examples of compact, simply connected essentially holomorphically pseudosymmetric Kählerian manifolds are discovered in [4]. In these examples, the structure functions change their signs on the manifold.
Statistical approximation to Bögel-type continuous and periodic functions
Authors: Dirik Fadime , Duman Oktay , Demirci Kamil 
Published: August 2009

Abstract
In this paper, considering A-statistical convergence instead of Pringsheim’s sense for double sequences, we prove a Korovkin-type approximation theorem for sequences of positive linear operators defined on the space of all real valued Bögel-type continuous and periodic functions on the whole real two-dimensional space. A strong application is also presented. Furthermore, we obtain some rates of A-statistical convergence in our approximation.
A lower bound for the error term in Weyl’s law for certain Heisenberg manifolds, II
Authors: Nowak Werner 
Published: August 2009

Abstract
This article is concerned with estimations from below for the remainder term in Weyl’s law for the spectral counting function of certain rational (2ℓ + 1)-dimensional Heisenberg manifolds. Concentrating on the case of odd ℓ, it continues the work done in part I [21] which dealt with even ℓ.
Content Validity of Written Examinations in Undergraduate Anatomy
Authors: Sultana Rubina , Shamim Khondker Manzare , Nahar Lutfun , Hasan Ferdous 
Published: August 2009

Objective: In ‘Curriculum' 2002 short answer questions are newly introduced. The content of 1st professional written examination was given but the weightage of different subdivision of Anatomy is not mentioned. So, present study was done to see the content validity of different subdivisions of Anatomy in written examinations. Study design: Descriptive type of study Place and period of study: The study was carried out from January 2003 to July 2004 in the Department of Anatomy, Bangabandhu Skeikh Mujib Medical University, Dhaka. Methods: It was based on a quantitative method; the question paper analysis based study. Results: It is evident from the questions paper analysis that different subdivisions of Anatomy are usually not given proper weight in the Anatomy written examinations. There are some subdivisions of Anatomy which are usually covered less than required. These include Genetics, Histology, General Anatomy, General Developmental Anatomy, Clinical Anatomy, etc. Conclusion: for further improvement of assessment system of Anatomy, content validity is needed to be established. Key words: Content validity, Anatomy, undergraduate, written examinations doi: 10.3329/bja.v7i1.3011 Bangladesh Journal of Anatomy January 2009, Vol. 7 No. 1 pp. 14-18
In Vivo Sensitized and In Vitro Activated B Cells Mediate Tumor Regression in Cancer Adoptive Immunotherapy
Authors: Li Qiao , Teitz-Tennenbaum Seagal , Donald Elizabeth J. , Li Mu , Chang Alfred E. 
Published: August 2009

AbstractAdoptive cellular immunotherapy utilizing tumor-reactive T cells has proven to be a promising strategy for cancer treatment. However, we hypothesize that successful treatment strategies will have to appropriately stimulate not only cellular immunity, but also humoral immunity. We previously reported that B cells in tumor-draining lymph nodes (TDLNs) may function as APCs. In this study, we identified TDLN B cells as effector cells in an adoptive immunotherapy model. In vivo primed and in vitro activated TDLN B cells alone mediated effective (p &lt; 0.05) tumor regression after adoptive transfer into two histologically distinct murine pulmonary metastatic tumor models. Prior lymphodepletion of the host with either chemotherapy or whole-body irradiation augmented the therapeutic efficacy of the adoptively transferred TDLN B cells in the treatment of s.c. tumors as well as metastatic pulmonary tumors. Furthermore, B cell plus T cell transfers resulted in substantially more efficient antitumor responses than B cells or T cells alone (p &lt; 0.05). Activated TDLN B cells conferred strong humoral responses to tumor. This was evident by the production of IgM, IgG, and IgG2b, which bound specifically to tumor cells and led to specific tumor cell lysis in the presence of complement. Collectively, these data indicate that in vivo primed and in vitro activated B cells can be employed as effector cells for cancer therapy. The synergistic antitumor efficacy of cotransferred activated B effector cells and T effector cells represents a novel approach for cancer adoptive immunotherapy.
Novel Reporter Mouse Reveals Constitutive and Inflammatory Expression of IFN-β In Vivo
Authors: Lienenklaus Stefan , Cornitescu Marius , Ziętara Natalia , Łyszkiewicz Marcin , Gekara Nelson , Jabłońska Jadwiga , Edenhofer Frank , Rajewsky Klaus , Bruder Dunja , Hafner Martin , Staeheli Peter , Weiss Siegfried 
Published: August 2009

AbstractType I IFN is a major player in innate and adaptive immune responses. Besides, it is involved in organogenesis and tumor development. Generally, IFN responses are amplified by an autocrine loop with IFN-β as the priming cytokine. However, due to the lack of sensitive detection systems, where and how type I IFN is produced in vivo is still poorly understood. In this study, we describe a luciferase reporter mouse, which allows tracking of IFN-β gene induction in vivo. Using this reporter mouse, we reveal strong tissue-specific induction of IFN-β following infection with influenza or La Crosse virus. Importantly, this reporter mouse also allowed us to visualize that IFN-β is expressed constitutively in several tissues. As suggested before, low amounts of constitutively produced IFN might maintain immune cells in an activated state ready for a timely response to pathogens. Interestingly, thymic epithelial cells were the major source of IFN-β under noninflammatory conditions. This relatively high constitutive expression was controlled by the NF Aire and might influence induction of tolerance or T cell development.
Basophils Can Directly Present or Cross-Present Antigen to CD8 Lymphocytes and Alter CD8 T Cell Differentiation into IL-10-Producing Phenotypes
Authors: Kim Sohee , Shen Tao , Min Booki 
Published: August 2009

Abstract
There is increasing evidence suggesting that basophils play a critical role in developing Th2-type immunity both in vitro and in vivo. We previously reported that basophils cocultured with naive CD4 T cells stimulated with Ag promote the differentiation of the T cells into IL-4-producing Th2 cells. In the present study, we examined the roles of basophils during CD8 T cell activation. Although stimulating OVA-specific OT-I CD8 T cells with OVA peptide-pulsed splenic dendritic cells primarily induced the production of IFN-γ, adding basophils into the coculture induced IL-10 production. Surprisingly, basophils were capable of directly presenting peptide Ag or of cross-presenting protein Ag to CD8 T cells. CD28-mediated costimulation dramatically enhanced T cell IL-10 production, yet neither ICOS nor CD86 was involved in IL-10 production. Basophil-mediated IL-10 induction was greatly diminished without IL-4 or IL-6, indicating that these cytokines are necessary for programming CD8 T cell IL-10 production. Adding IL-4 or IL-6 into CD8/APC coculture was not sufficient to induce IL-10 production; however, the presence of both cytokines significantly induced IL-10 production without basophils. Finally, CD8 T cells producing IL-10 induced by basophils did not display regulatory cell functions. Collectively, these results suggest a novel function of basophils that act as professional APCs to present Ag to CD8 T cells, thus inducing IL-10 production.
Roles of the TRAF2/3 Binding Site in Differential B Cell Signaling by CD40 and Its Viral Oncogenic Mimic, LMP1
Authors: Graham John P. , Moore Carissa R. , Bishop Gail A. 
Published: August 2009

Abstract
The EBV protein, latent membrane protein 1 (LMP1), is a functional mimic of the cellular receptor CD40, but signals to B lymphocytes in an amplified and sustained manner compared with CD40. LMP1 contributes to the development of B cell lymphoma in immunosuppressed patients, and may exacerbate flares of certain autoimmune diseases. The cytoplasmic domain of LMP1 binds the signaling adaptor TRAF2 with lower avidity than the cytoplasmic domain of CD40, and TRAF2 is needed for CD40-mediated degradation of TRAFs 2 and 3. LMP1 doesn’t induce TRAF degradation, and employs TRAF3 as a positive mediator of cell signaling, whereas CD40 signals are inhibited by TRAF3. We thus tested the hypothesis that relative affinity for TRAF2, and/or distinct sequence differences in the TRAF2/3 binding sites of CD40 vs LMP1, controls the disparate ways in which CD40 and LMP1 use TRAFs 2 and 3, and their distinct signaling characteristics. CD40 and LMP1 mutants in which the TRAF binding site sequences were swapped were examined, testing TRAF binding and degradation, and induction of B cell activation. Results revealed that TRAF binding affinity and TRAF binding site sequence dictate a distinct subset of CD40 vs LMP1 signaling properties. Examination of TRAF binding, degradation, cytokine production, IgM secretion, and the activation of c-Jun kinase and NF-κB revealed that some events are dictated by TRAF binding site sequences, others are partially regulated, and still others are independent of the TRAF binding site sequence.
Complement Protease MASP-1 Activates Human Endothelial Cells: PAR4 Activation Is a Link between Complement and Endothelial Function
Authors: Megyeri Márton , Makó Veronika , Beinrohr László , Doleschall Zoltán , Prohászka Zoltán , Cervenak László , Závodszky Péter , Gál Péter 
Published: August 2009

Abstract
Activation of the complement system can induce and enhance inflammatory reaction. Mannose-binding lectin-associated serine protease-1 (MASP-1) is an abundant protease of the complement lectin pathway; however, its physiological function is unclear. In this study, we demonstrate for the first time that MASP-1 is able to activate Ca2+ signaling, NF-κB, and p38 MAPK pathways in cultured HUVECs. Activation was initiated by MASP-1 only; the related protease, MASP-2, had no such effect. The phenomenon was dependent on the proteolytic activity of MASP-1, suggesting modulation of endothelial cell function through a protease-activated receptor (PAR). Using synthetic peptide substrates representing the protease-sensitive regions of PARs, we were able to demonstrate that PAR4 is a target of MASP-1. The presence of functionally active PAR4 in HUVECs was demonstrated using PAR4 agonist peptide and mRNA quantification. Finally, we showed that the amount of membrane-bound intact PAR4 decreases after MASP-1 treatment. All of these results provide a novel link between the regulation of endothelial cell function and complement system activation, and they suggest that MASP-1-induced PAR4 activation could contribute to the development of the inflammatory reaction.
Smallpox Inhibitor of Complement Enzymes (SPICE): Dissecting Functional Sites and Abrogating Activity
Authors: Liszewski M. Kathryn , Leung Marilyn K. , Hauhart Richard , Fang Celia J. , Bertram Paula , Atkinson John P. 
Published: August 2009

Abstract
Although smallpox was eradicated as a global illness more than 30 years ago, variola virus and other related pathogenic poxviruses, such as monkeypox, remain potential bioterrorist weapons or could re-emerge as natural infections. Poxviruses express virulence factors that down-modulate the host’s immune system. We previously compared functional profiles of the poxviral complement inhibitors of smallpox, vaccinia, and monkeypox known as SPICE, VCP (or VICE), and MOPICE, respectively. SPICE was the most potent regulator of human complement and attached to cells via glycosaminoglycans. The major goals of the present study were to further characterize the complement regulatory and heparin binding sites of SPICE and to evaluate a mAb that abrogates its function. Using substitution mutagenesis, we established that (1) elimination of the three heparin binding sites severely decreases but does not eliminate glycosaminoglycan binding, (2) there is a hierarchy of activity for heparin binding among the three sites, and (3) complement regulatory sites overlap with each of the three heparin binding motifs. By creating chimeras with interchanges of SPICE and VCP residues, a combination of two SPICE amino acids (H77 plus K120) enhances VCP activity ∼200-fold. Also, SPICE residue L131 is critical for both complement regulatory function and accounts for the electrophoretic differences between SPICE and VCP. An evolutionary history for these structure-function adaptations of SPICE is proposed. Finally, we identified and characterized a mAb that inhibits the complement regulatory activity of SPICE, MOPICE, and VCP and thus could be used as a therapeutic agent.
Economic Evaluation of Enhanced vs Standard Varenicline Treatment for Tobacco Cessation
Authors: Mundt Marlon P. , Stein James H. , Fiore Michael C. , Baker Timothy B. 
Published: April 2024

ImportanceSmoking is the leading preventable cause of death and illness in the US. Identifying cost-effective smoking cessation treatment may increase the likelihood that health systems deliver such treatment to their patients who smoke.ObjectiveTo evaluate the cost-effectiveness of standard vs enhanced varenicline use (extended varenicline treatment or varenicline in combination with nicotine replacement therapy) among individuals trying to quit smoking.Design, Setting, and ParticipantsThis economic evaluation assesses the Quitting Using Intensive Treatments Study (QUITS), which randomized 1251 study participants who smoked into 4 conditions: (1) 12-week varenicline monotherapy (n = 315); (2) 24-week varenicline monotherapy (n = 311); (3) 12-week varenicline combination treatment with nicotine replacement therapy patch (n = 314); or (4) 24-week varenicline combination treatment with nicotine replacement therapy patch (n = 311). Study enrollment occurred in Madison and Milwaukee, Wisconsin, between November 11, 2017, and July 2, 2020. Statistical analysis took place from May to October 2023.Main Outcomes and MeasuresThe primary outcome was 7-day point prevalence abstinence (biochemically confirmed with exhaled carbon monoxide level ≤5 ppm) at 52 weeks. The incremental cost-effectiveness ratio (ICER), or cost per additional person who quit smoking, was calculated using decision tree analysis based on abstinence and cost for each arm of the trial.ResultsOf the 1251 participants, mean (SD) age was 49.1 (11.9) years, 675 (54.0%) were women, and 881 (70.4%) completed the 52-week follow-up. Tobacco cessation at 52 weeks was 25.1% (79 of 315) for 12-week monotherapy, 24.4% (76 of 311) for 24-week monotherapy, 23.6% (74 of 314) for 12-week combination therapy, and 25.1% (78 of 311) for 24-week combination therapy, respectively. The total mean (SD) cost was $1175 ($365) for 12-week monotherapy, $1374 ($412) for 12-week combination therapy, $2022 ($813) for 24-week monotherapy, and $2118 ($1058) for 24-week combination therapy. The ICER for 12-week varenicline monotherapy was $4681 per individual who quit smoking and $4579 per quality-adjusted life-year (QALY) added. The ICER for 24-week varenicline combination therapy relative to 12-week monotherapy was $92 000 000 per additional individual who quit smoking and $90 000 000 (95% CI, $15 703 to dominated or more costly and less efficacious) per additional QALY.Conclusions and RelevanceThis economic evaluation of standard vs enhanced varenicline treatment for smoking cessation suggests that 12-week varenicline monotherapy was the most cost-effective treatment option at the commonly cited threshold of $100 000/QALY. This study provides patients, health care professionals, and other stakeholders with increased understanding of the health and economic impact of more intensive varenicline treatment options.
Terahertz Magnetic Moiré Grating for Enhanced Chirality Manipulation and Nonreciprocal Spin Isolation
Authors: Zhao Dan , Fan Fei , Xue Qiang , Wang Hao , Ji Yunyun , Yang Qinghui , Wen Qiye , Chang Shengjiang 
Published: April 2024

AbstractMagneto‐optical activity is a significant way to achieve asymmetric transmission for spin photons. However, it is severely limited by the weak light‐matter interaction in the terahertz (THz) region. In this work, a magnetic Moiré grating (MMG) is constructed by sandwiching an Yttrium iron garnet (YIG) single crystal in a pair of twisted 2D subwavelength gratings. The twisted angle between two gratings introduces a strong geometric Moiré chirality related to the Moiré pattern. When an external magnetic field is applied to the YIG layer, three different symmetries of spacial mirror image, time reversal, and spin conjugation are broken simultaneously under the chiral coupling between magneto‐optical activity and Moiré chirality, leading to both the enhanced magneto‐optical chiral transmission and the nonreciprocal spin isolation. Under the magnetic field varying from −0.26 to +0.26 T in the experiment, the MMG achieves an active modulation of circular dichroism from 39 to −37.5 dB and optical activity from −35° to 30°. Moreover, the maximum spin isolation over 32.6 dB is also obtained near 0.5 THz. This mechanism provide a new way to realize independent manipulation and active modulation of THz spin photons more flexibly.