bluuebunny/crossref_metadata_2025_split huggingface dataset:
Intravenous Leiomyomatosis of the Uterus: A Light and Electron Microscopic Study
Authors: Konishi Ikuo , Fujii Shingo , Takakura Kenji , Ukita Masahiko , Mori Takahide 
Published: August 2010

AbstractA 45‐year‐old woman with intravenous leiomyomatosis of the uterus underwent total hysterectomy with bilateral salpingo‐oophorectomy and stripping of intravascular cord‐like nodules from within uterine and ovarian veins. Light and electron microscopic studies showed the tumor to possess both extra‐ and intra‐vascular growths, both of which had the same angiomatous features characterized by a palisaded arrangement of smooth muscle‐like cells around the lumina of many small blood vessels. Ultrastructurally, the main tumor cells were those having smooth muscle features. They surrounded endothelial cells and pericytes. The identification of both mature and immature smooth muscle cells in these tumors suggests that multi‐potential mes‐enchymal cells are the source of the tumor. The pattern of palisaded cells arranged around blood vessels, as well as the intra‐ and extra‐vascular growth, suggests an origin in the vascular wall.
Intestinal Parasitism: A Survey of Patients Attending an Antenatal Clinic in the New Territories of Hong Kong
Authors: Rogers Michael S. , Chang Allan M. Z. , French Gary L. 
Published: August 2010

AbstractA prospective survey of patients booking for antenatal care at the Prince of Wales Hosptial was performed, to ascertain the prevalence of intestinal parasitism in such patients, to assess the socio‐demographic factors which may contribute to infestation and to estimate the contribution of intestinal parasites to anemia of pregnancy in the New Territories of Hong Kong.Parasites were found in 19% of stools of all patients but the prevalence in the immigrant population from the Chinese mainland was 40% compared to only 7% in those women born in Hong Kong. The incidence of anemia was no different in patients with parasitic infestation than those without.
Development of Urine Production and Urination in the Human Fetus Assessed by Real‐Time Ultrasound
Authors: Shin Takeshi , Koyanagi Takashi , Hara Kenji , Kubota Shiroo , Nakano Hitoo 
Published: August 2010

AbstractTo evaluate the physiological profile of fetal urine production with advance in gesta‐tional age, we observed the volume of urine retained in the bladder, using real‐time ultrasound. Here, the parameters of maximum urine volume, periodicity of urination and the urine production rate were analyzed. Urine volume can be measured by 3 orthogonal diameters of the bladder, provided that the stereognostic image of the bladder is assumed to be an ellipsoidal configuration. Investigated were 1,261 normal fetuses between 12 and 42 weeks of gestation. Three critical ages were noted, with respect to development of urine production and urination: 12, 18–20, and approximately 37–38 weeks of gestation. The first and the second indicate the onset of urine production and the start of alternating changes in urinary retention and urination, respectively. From the third period toward the end of the pregnancy, the urine production rate begins to decline.
Size‐at‐Birth Standards for a Melanesian Population
Authors: Burrows R. F. 
Published: August 2010

AbstractBy sampling all singleton births occurring to clinic‐attending Nivanuatu over an 18‐month period, the percentile distributions of the newborn infant's weight, length and head and chest circumferences were determined. The mean values for males and females respectively were: birth weight 3,162 and 3,085 g, crown‐heel length 50.6 and 50.1 cm, head circumference 34.3 and 33.7 cm, and chest circumference 31.6 and 31.5 cm. The resulting standards may be used in the clinical evaluation of size for gestational age.
Struma Ovarii: A Case Report
Authors: Salvi Vinita S. , Rao Reshma R. , Shroff Rekha R. , Walvekar Vandana R. , Pandit Ramesh D. 
Published: August 2010

AbstractSmall amounts of thyroid tissue are found infrequently in ovarian teratomas. Rarely, the thyroid tissue dominates, and such tumors are called struma ovarri. We record a case of struma ovarri in a 26‐year‐old patient who presented with a lump in the abdomen and primary infertility. A left oophorectomy with omentectomy was performed.
The Role of Peripheral Blood Monocyte on Cell‐Mediated Immunity in Pregnant Women
Authors: Umesaki Naohiko , Kawabata Masami , Sugawa Tadashi 
Published: August 2010

AbstractIn this work, we studied the monocyte function as accessory cells to T‐cells during and after pregnancy. The function tended to decrease in the 1st trimester, but showed a significant increase in the 3rd trimester (p<0.01). After parturition, it returned to normal. Next, the effect of pregnant serum on the monocyte function was studied. Pregnant serum was found to enhance the monocyte function, and this was most apparent in the samples obtained in the 3rd trimester. These facts led us to study the roles of a number of hormones whose serum levels change dynamically during pregnancy. We found that the monocyte function was enhanced 41% when estrogen was added in concentrations equivalent to the in vivo level during the 3rd trimester, and inhibited 40% by cortisol.These observations suggest that monocytes play an important role in cell‐mediated immunity during pregnancy and that pregnant serum, especially hormones, influence the monocyte function.
Stimulatory Action of Progesterone on the Synthesis of Glycogen in Primary Cell Culture of Human Endometrium
Authors: Ishihara Satoko , Taketani Yuji , Mizuno Masahiko 
Published: August 2010

AbstractThe effects of progesterone and its antagonist, RU486, on the synthesis of glycogen were investigated using a primary cell culture of human endometrium. Progesterone stimulated the glycogen synthesis in a dose‐dependent manner. The minimal effective dose of progesterone is 10‐9 M with maximal effect occurring at 10‐7 M. Stimulation of glycogen synthesis was apparent as early as after 6 hours of incubation. Progesterone induced the activity of glycogen synthetase and reduced the activity of glycogen phosphorylase. The addition of RU486 with progesterone completely eliminated the action of progesterone in both the synthesis of glycogen and the activity of glycogen synthetase. These results clearly demonstrate the stimulatory action of progesterone in glycogen synthesis in cultured human endometrial cells. Moreover, the antiprogesterone, RU486, is shown to counteract the progesterone action in glycogen synthesis in vitro.
Pregnancy in a Woman with Wilson's Disease Treated with Zinc
Authors: Lao Terence T. H. , Chin Robert K. H. , Cockram Clive S. , Leung Nancy W. Y. 
Published: August 2010

AbstractA 29‐year‐old Chinese housewife with a 7‐year history of Wilson's disease complicated by severe ataxia, hepatic cirrhosis, splenectomy, allergy to penicillamine and 2 spontaneous abortions, was referred at 23 weeks gestation in her fourth pregnancy which was conceived within a month of a 3‐month course of treatment with zinc sulphate 450 mg daily. She delivered at 37 weeks of a 2,700 g female baby. As zinc has been used successfully as an alternative to chelating agents in non‐pregnant patients, it may become a useful drug for treating pregnancy patients with Wilson's disease in place of penicillamine.
Recurrent Tetra‐Amelia: Ultrasonographic Diagnosis in Early Pregnancy
Authors: Miyakawa Isao , Yasuda Hiroshi , Yanagita Kenichi , Yamaguchi Masatoshi , Mori Norimasa 
Published: August 2010

AbstractA woman who had previously given birth to a child with tetra‐amelia was sonographically diagnosed to have again conceived a fetus with the same anomaly. Although recurrent tetra‐amelia is extremely rare, ultrasonographic imaging proved to be very useful in detecting this limb reduction defect in early pregnancy.
Intrauterine Diagnosis of Epignathus Using Ultrasonic Tomography
Authors: Shouno Hideaki , Matsuo Norihito , Miyabara Shinichi , Yamasaki Miyoshi , Kuriyama Kazufumi , Sugimori Hajime 
Published: August 2010

AbstractA case of fetal epignathus was evaluated by 2 new approaches (morphological and functional) using ultrasonic tomography. In the morphological study, serial interval tomograms were converted using a microcomputer into 3‐dimensional images for easier and more accurate diagnosis. In respect to function of cardiovascular system, not only placental enlargement and overswelling of the internal jugular vein were observed, but elevated function in the fetal left ventricle and hypofunction in the right ventricle were revealed by M‐mode ultrasonography. The evidence from these examination and the autopsy seemed to support the double monster theory for the origin of epignathus.
Prenatal Diagnosis of Exstrophy of the Cloaca with Ectopia Cordis
Authors: Nishi Takenori , Yamoto Mareo , Nakano Ryosuke 
Published: August 2010

AbstractUltrasonic techniques allow for noninvasive detection of prenatal abnormalities. The management of a delivered baby and the subsequent course are strongly influenced by intrauterine detection. A case of exstrophy of the cloaca with ectopia cordis was prenatally diagnosed by ultrasonography. Ectopia cordis and exstrophy of the cloaca are both rare anomalies. Ectopia cordis can be detected when the heart is outside the thoracic cage and a small thorax is seen on the ultrasonography. Exstrophy of the cloaca can be suspected when omphalocele and meningomyelocele are present, the urinary bladder is absent, and internal and/or external genitalia are abnormal by ultrasonography. Careful and repeated ultrasound study will confirm the combined anomalies of ectopia cordis and exstrophy of the cloaca.
Efficacy of γ‐Globulin Infusion Followed by Platelet Transfusion in Patient with Aplastic Anemia during Pregnancy: A Case
Authors: Mano Takafumi , Takeshima Nobuhiro , Miyake Teruhiko 
Published: August 2010

AbstractA case of aplastic anemia with positive antiplatelet antibody during pregnancy is summarized.A single 400 mg/kg dose of γ‐globulin was given intravenously, on August 9, at 35 weeks' gestation, soon after spontaneous rupture of the membranes. During injection of γ‐globulin, labor began spontaneously and a viable 1,980 g infant was delivered by spontaneous vaginal delivery. After parturition, vaginal hematoma developed. Following the γ‐globulin injection, a 13‐unit platelet concentrate, 250 ml of platelet concentrate produced at the Shuto Hospital and 1,000 ml of fresh blood were injected. After these blood transfusions, bleeding from vagina subsided. Twelve hours later the platelet count was 33,000/mm3.It is suggested that γ‐globulin infusion followed by platelet transfusions may be a practical way to control hemorrhage during parturition in women with positive antiplatelet antibodies and aplastic anemia.
The Determination of CA‐50 Antigen in Women with Cervical Cancer
Authors: Dodd J. K. , Henry R.J.W. , Tyler J.P.P. , Houghton C.R.S. 
Published: August 2010

AbstractSerum from 97 women with histologically proven squamous cell cervical carcinoma were analysed for the presence of tumour marker CA‐50 using a commercially available assay (DELFIA). Although values ranged between 0.5–573.3 U/ml the majority of cases (75%) fell below 21.2 U/ml. There was no relationship between CA‐50 antigen values and clinical stage of the disease as defined by FIGO, or prognosis. Furthermore the high false negative rate of this marker (51.5%) in patients with proven disease, and the lack of response following treatment, would preclude its use as a diagnostic screen.
Evidence Suggesting the Trophoblastic Origin of Follicle‐Stimulating Hormone, Luteinizing Hormone and Prolactin in Hydatidiform Mole
Authors: Loganath A. , Peh K. L. , Gunasegaram R. , Ratnam S. S. 
Published: August 2010

AbstractOur previous finding that the intravesicular fluid of hydatidiform mole contains high concentrations of follicle stimulating hormone (FSH), luteinizing hormone (LH) and prolactin (PRL) suggested to us that the molar trophoblast may be able to synthesize polypeptide hormones just as it produces human chorionic gonadotrophin (hCG). Using radioimmunoassay, we examined the plasma concentrations of these hormones before and after evacuation of the molar tissues, because we believed that this procedure might identify the source of increased FSH, LH and PRL synthesis in hydatidiform moles. Our 4 subjects had markedly elevated pre‐evacuation plasma levels of FSH (9.0–12.5 IU/l), LH (135,000–340,000 IU/l), PRL (1,300–3,800 mIU/l) and β‐hCG (550,000–4,500,000 IU/l). Their liver and kidney function tests were normal. After molar evacuation, serial concentrations of FSH, LH and PRL progressively declined to near normal levels by 9–16 weeks. As expected, the changes in FSH, LH and PRL levels closely resembled the typical pattern of changes in β‐hCG levels and decreased to the lower limits of sensitivity of the assay (<2.5 IU/l at 9–12 weeks). The pattern and magnitude of the changes strongly suggest that the diseased trophoblast makes a significant contribution to circulating levels of the 4 hormones.
The Value of Cervical Punch Biopsy in the Assessment of Histopathological Prognostic Factors in Carcinoma of the Cervix
Authors: Ngan Hextan Y. S. , Hsu Chih , Wong Ling C. , Ma Ho K. 
Published: August 2010

AbstractFrom 1976 to 1980, 88 patients with stage Ib and early stage II squamous cell carcinoma of the cervix had the histological slides of their pretreatment cervical biopsies reviewed. Histological features of the biopsied tissue like cell type, cell differentiation, lymphatic or vascular permeation and stromal inflammatory cell reactions were assessed. In contrary to previous studies, the present study failed to show any significant correlations between these various histological features and the survival rate except in patients with moderate to severe plasma cell infiltration who had a better survival rate than those with absent to minimal plasma cell infiltration. Cervical punch biospy is of no value in the prediction of the prognosis of patients with squamous cell carcinoma of the cervix.
Fetal Growth and Glucose Metabolism in Diabetic Pregnant Rats
Authors: Murata Kazuhira , Ichio Takao , Yoshimura Kouichi , Toyoda Nagayasu , Sugiyama Youichi 
Published: August 2010

AbstractWe have studied the effects of diabetes on fetal growth, glucose metabolism, lung maturation, and bone development in rats. Fetuses in diabetic rats showed decreased body weights and increased placental weights. A morphological study of the fetal pancreas suggested that the area of the islets was increased. Plasma insulin levels and pancreatic levels of insulin and somatostatin were decreased, while plasma glucagon levels were unchanged. The levels of glycogen, glycogen synthase activity and somatomedin‐C were increased in the fetal liver. The serum transferrin levels were decreased and correlated with the reduced body weights. The levels of insulin and cortisol in the amniotic fluid and the weights of lungs were decreased. Levels of phosphatidylcholine (PC) in the lung and the abilities to synthesize PC and phosphatidylglycerol (PG) from glucose were decreased. The incidence of lumbar and cervical ribs was about 2–5 times higher than normal. Evidence of decreased ossification was also present. The fetuses of insulin‐treated diabetic rats, in which blood glucose concentrations before and during pregnancy were rigidly controlled, showed dramatic improvement in all these parameters to values near to those of the controls.
Pathological State of the Coagulatory and Fibrinolytic System in Preeclampsia and thePossibility of Its Treatment with AT III Concentrate
Authors: Terao Toshihiko , Kobayashi Takao , Imai Nobuaki , Oda Hiroyuki , Karasawa Tetsuro 
Published: August 2010

AbstractForty patients with preeclampsia were collected, and 27 of these cases were treated with AT III concentrate (1,000–2,000 units/day) for 7 days. According to an evaluation of objective clinical efficacy by the degree of improvement of GI scores in patients with preeclampsia, the number of effective cases was significantly greater among the treated groups than among the untreated groups (p<0.05). The rate of efficacy of the treated groups was 40%, compared with 0% in the untreated groups. In severe preeclampsia, a decrease in AT III activity was noted in 56.7%, a decrease in platelet count in 62.1%, and an increase in plasma FDP in 46.2%, A significant correlation was found between the GI score and the AT III activity. The anticoagulation therapy using AT III may normalize the chronic coagulation accelerated state in preeclampsia, and a good influence on the fetus may be expected.
Measurement of α‐Fetoprotein and Fetal Erythrocyte Levels for Detecting Fetomaternal Hemorrhage
Authors: Hida Shuji 
Published: August 2010

AbstractThis study was designed to measure changes in AFP levels and increases in fetal red cells in maternal blood before and after delivery to detect fetomaternal hemorrhaging in 41 full‐term singleton deliveries. Discrepancy was noted between the increase in fetal red cells and the elevation of AFP levels. Six cases (14.6%) showed both elevation of AFP levels and an increase in fetal red cells. Six showed elevation of HbF concentration with stable AFP levels, and another 6 showed an increase in maternal serum AFP levels with stable HbF concentration. The measurements of maternal serum AFP levels seem highly useful for detecting FMH in the presence of fetomaternal blood incompatibility.
Fourteen Years' Experience of Management and Use of the Perinatal Data‐Base System
Authors: Shinozuka Norio , Okai Takashi , Mukubo Masaaki , Baba Kazunori , Kuwabara Yoshinori , Mizuno Masahiko 
Published: August 2010

AbstractSince 1973, we have been recording the data of all obstetric cases in our department in our original data‐base system, which was created on the mainframe computer at the Tokyo University Hospital Computer Center. The purposes of this system are mainly for making summaries of patients, for retrieving information of cases to provide data for clinical investigations, and for collecting statistics. The data records consist of 225 items, including different kinds of perinatal information. Our data‐base system has been useful in improving perinatal medicine, in clinical investigations, and in our daily work. But after 14 years of experience with it, we recognize the system has problems, namely: 1) How to summarize perinatal data to be used as a substitute for a patient history chart, and 2) How to update the data‐base with a little change in format according to improvements of perinatal medicines.
Serological Screening for Syphilis during Pregnancy in a Multiethnic Asian Population
Authors: Goh Tai H. , Ngeow Y. F. 
Published: August 2010

AbstractOut of 14,841 women who were serologically examined for syphilis at the antenatal booking clinic, University Hospital, Kuala Lumpur in Malaysia, 1.78% were VDRL positive and 1.05% TPHA positive with significant differences between the Malays, Indians and Chinese. These rates are higher than published series and were attributed to childhood yaws infection among the Malays. As differentiation between yaws and syphilitic infection in the clinic is difficult, all TPHA‐reactive women were treated as for syphilis. Congenital syphilis was not diagnosed in those women who had been effectively treated before delivery.
Successful Treatment of Cervical Pregnancy by Cervical Evacuation after Use of Methotrexate
Authors: Kim Doo‐Sang , Hwang Youn‐Yeoung , Park Moon‐Il 
Published: August 2010

AbstractA case is described with cervical pregnancy successfully treated by two 8‐day courses of methotrexate and leucovorin rescue with cervical evacuation. The apparent beneficial outcome suggests that cervical evacuation after the use of methotrexate and leucovorin rescue will be considered for treatment of cervical pregnancy whenever uterine preservation is desirable.
The Problem of Hemoglobin Switching in Premature Infants and IUGR Infants
Authors: Moriyama Ikuko , Hino Koji , Ninomiya Yuko , Nabuchi Kaoru , Kato Yumiko , Tsuji Yoshimasa , Ichijo Motohiko 
Published: August 2010

AbstractUnderstanding the hemoglobin switching regulation mechanism in extremely premature infants is particularly important for understanding the extrauterine adaptation of the infants. In this study, we sought to identify factors influencing oxygen affinity in fetal blood and neonatal blood and obtained these results.(1) Aging is required for hemoglobin switching.(2) Switching in premature infants (27 to 32 weeks) is delayed at least 3 weeks in comparison with full‐term infants.(3) A delay in the switching of fetal hemoglobin to adult hemoglobin was confirmed in IUGR (intrauterine growth retardation) infants. However, there is a compensatory increase in 2, 3‐DPG for adaptation after birth.(4) A delay in 2, 3‐DPG increase was observed in RDS (respiratory distress syndrome) infants, and oxygen affinity remained high.
Effects of Pre‐Ovulatory X‐Irradiation on Fertilization, Initial Cleavage and Post‐Nidation Development in the Chinese Hamster
Authors: Imaizumi Katsuhide 
Published: August 2010

AbstractIn order to investigate the effects of pre‐ovulation X‐ray radiation on fertilization, initial cleavage and post‐nidation development, Chinese hamster dams were mated with normal males after exposure to 200 rads of radiation during the primary maturation period, and cytogenetic studies were performed at 2.5, 3.5 and 10 days after fertilization; comparison studies were also performed on an untreated control group.The results indicated that: (1) The ovarian ova with chromosomal anomalies induced by X‐ray radiation had the ability to be fertilized and transmit the abnormality to the 2‐celled stage, but most of them deceased by the 8‐celled stage. (2) The embryos attaining the 8‐celled stage with normal chromosomes were implanted and survived, but showed remarkable hypoplasia on day 10 of gestation.
Cervical Mucus Prolactin Levels in Normal Fertile and Infertile Women
Authors: Shaarawy Mohamed , Darwish Nabil A. , Nagui Abdel‐Rehim , Ezzat Rawia A. 
Published: August 2010

AbstractCervical mucus and serum samples were obtained from 42 anovular women and 20 normal ovular fertile women (controls) for the determination of prolactin concentration by a solid phase radioimmunoassay. The former group was subgrouped into 14 galactorrhoeic (9 with oligohypomenorrhea and 5 with amenorrhea) and 28 non‐galactorrhoeic (19 with oligohypomenorrhea and 9 with amenorrhea). The level of prolactin in cervical mucus of normally menstruating women was significantly higher than that of serum at P<0.0125 (11.68·0.77 ng/ml and 16.09·1.65 ng/ml, mean SE, respectively).Serum prolactin level in galactorrhoeic amenorrhea cases was 8.2 times that of controls, while cervical mucus prolactin amounted to 32 times its control value. The rise of cervical mucus prolactin in cases of galactorrhea oligohypomenorrhea was 21 times its control value which is markedly higher than that of serum (1.9 times). The average rise of serum prolactin in the whole group of galactorrhea with abnormal menstrual function was about 4 times the control value, while the average rise of cervical mucus prolactin was about 41 times the corresponding control value.In the cases of galactorrhea with menstrual dysfunction, serum prolactin level may be normal in 50% of cases, while cervical mucus prolactin is strikingly elevated in 100% of cases. The possibility of pituitary adenoma should be considered if the level of serum or cervical mucus prolactin exceeds 100 ng/ml and 600 ng/ml respectively. The possible physiological role of cervical mucus prolactin and its source are discussed.