bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mechanisms of Antihypertensive Effect of Chlorthalidone in Advanced Chronic Kidney Disease
Authors: Agarwal Rajiv , Sinha Arjun D. , Tu Wanzhu 
Published: June 2024

Key Points

Chlorthalidone reduces the amount of fluid and the BP, but fluid volume reduction is not the cause of lowering of BP.It is not volume loss but the response to volume loss such as the synthesis of substances that lower BP is important.

Background
Chlorthalidone (CTD) in a chronic kidney disease randomized trial demonstrated a robust reduction in systolic BP in stage 4 CKD. In this study, we explore the mechanisms underlying the antihypertensive effect of CTD.

Methods
In this prespecified analysis, we analyzed the contributions of baseline levels of 24-hour urinary sodium and aldosterone and the changes from baseline to 4 weeks in the multiple mediators reflecting volume status in a causal mediation analysis framework. Baseline levels of these mediators served as covariates. No power calculation for this analysis was performed.

Results
Of the 160 patients randomized, 140 (87.5%) were included in this analysis. Compared with placebo, CTD within 4 weeks reduced weight −1.5% (95% confidence interval [CI], −2.2 to −0.7) and volume −1.4% (95% CI, −2.2 to −0.6), stimulated plasma renin 40.5% (95% CI, 25.4% to 57.4%) and serum aldosterone 40.2% (95% CI, 11.7% to 76%), and reduced plasma N-terminal pro-B-type natriuretic peptide levels −19.4% (95% CI, −33.8% to −1.9%). Mediation analysis revealed the following results: for weight change, the total effect on systolic BP was −10.8 mm Hg (95% CI, −16 to −5.7), of which weight change (indirect effect) accounted for −0.9 mm Hg (95% CI, −4.2 to 2.5) and BP change independent of weight (direct effect) accounted for −10 mm Hg (−15.7 to −4.2). Thus, the percent mediation was 8.1% (95% CI, −22.4 to 38.5). Baseline excretion of 24-hour sodium or aldosterone or any of the changes in the above mediators examined accounted for <2 mm Hg BP drop and were not significant for any of the mediators.

Conclusions
CTD improved BP control among patients with advanced CKD independent of baseline urinary sodium, aldosterone, weight loss, or changes in the renin-angiotensin system or N-terminal pro-B-type natriuretic peptide.

Clinical Trial registry name and registration number:
CTD in chronic kidney disease ClinicalTrials.gov number: NCT02841280.
PENGARUH STRATEGI PEMASARAN PUSH DAN PULL DIGITAL MARKETING TERHADAP PURCHASE INTENTION ASURANSI JIWA DI PT. CHUBB LIFE INSURANCE MEDAN
Authors: Parinduri Islah Rizky , Nasution Muhammad Lathief Ilhamy , Atika Atika 
Published: June 2024

Mempromosikan adalah suatu gerakan bisnis atau pertukaran dengan menawarkan barang kepada pelanggan dengan tujuan agar kebutuhan dan pemenuhan pembeli terpenuhi. Push marketing melibatkan inisiatif pemasaran yang proaktif di mana pesan-pesan pemasaran ditekan kepada konsumen. Ini bisa mencakup iklan berbayar di media sosial, email,atau promosi di situs web. Pull marketing berfokus menarik konsumen secara sukarela dengan konten edukatif seperti artikel blog tentang manfaat asuransi jiwa.Tujuan dari eksplorasi ini yaitu agar mengetahui pengaruh startegi pemasaran push dan pull digital marketing terhadap purchase intention asuransi jiwa di PT.Chubb Life Insurance Medan. Teknik yang diperlukan pada eksplorasi ini yaitu metode pemeriksaan kuantitatif yang memakai desain eksplorasi analitik deskripftif dengan pendekatan cross secsional. Banyak sampel eksplorasi sekitar 60 individu. Temuan eksplorasi memperlihatkan ada pengaruh signifikan antara Strategi Pemasaran Push dan Pull Digital Marketing Terhadap Purchase Intention Asuransi Jiwa Di Pt. Chubb Life Insurance Medan. Hasil uji Fisher Exact didapatkan nilai p=0,000 (p<0.05).
Pengaruh Peredaran Bumi Terhadap Penentuan Awal Waktu Salat Perspektif Fikih Ibadah dan Astronomi
Authors: Dwi Utami  , Amir Rahma , Mustafa Adriana 
Published: June 2024

Abstrak
Waktu salat ditetapkan berdasarkan kedudukan matahari diukur dari suatu tempat di permukaan bumi. Menghitung waktu salat pada hakekatnya adalah menghitung posisi matahari sesuai dengan kriteria yang ditetapkan. Posisi matahari tidak selalu sama di setiap harinya, hal ini karena revolusi bumi yang menyebabkan gerak semu harian matahari sehingga memungkinkan wakktu salat kita tidak sama setiap hari.
Penelitian ini menggunakan penelitian pustaka (library research) dalam artian mencari artikel, skripsi, jurnal dan buku yang berhubungan dengan judul penulis. Adapun pendekatan yang penulis gunakan adalah pendekatam syar’i dan pendekatan astronomis. Menurut sumber datanya, data penelitian dibagi menjadi dua data, yakni data primer dan data sekunder.
Hasil penelitian ini menunjukkan bahwa Perspektif fikih ibadah terhadap peredaran bumi dalam penentuan waktu salat yaitu pada waktu Zuhur saat matahari tergelincir, waktu Asar saat bayang-bayang benda melebihi panjang bendanya atau 2 kali panjang bendanya, waktu Magrib saat tenggelamnya matahari, waktu Isya pada saat hilangnya mega merah, dan waktu subuh pada saat terbit fajar shadiq. Adapun perkembangan ilmu astronomi terhadap penentuan awal waktu salat yaitu pada awalnya manusia menentukan dengan melihat langsung perubahan bayangan matahari. Lalu seiring berkembangnya zaman muncul beberapa alat tradisional dan modern, perhitungan waktu salat menggunakan data astronomis yang akurat, aplikasi dan software tentang jadwal waktu salat sehingga memudahkan umat islam dalam menentukan dan melaksanakan salat.
Kata Kunci: Astronomi, Fikih Ibadah, Peredaran Bumi, Waktu salat
MaxEnt modelling for predicting habitat suitability and future range of Black-breasted Parrotbill (Paradoxornis flavirostris Gould, 1836) in Northeast India
Authors: Bora Chiranjib , Saikia Prasanta Kumar 
Published: June 2024

Abstract
Habitat suitability models are powerful tools in predicting species distributions and assessing the potential impacts of environmental changes. In this article, a habitat suitability model was developed for Paradoxornis flavirostris, a threatened (Vulnerable) bird species found in the northeastern part of India, using remote sensing data and machine learning techniques. The occurrence records for P. flavirostris were considered from primary as well as multiple secondary sources like GBIF & eBird, and bioclimatic variables such as temperature, precipitation, and humidity were collected from www.worldclim.org. Then, MaxEnt algorithm was used to model the habitat suitability of P. flavirostris based on the collected data. Additionally, the model was also run to project the future range of P. flavirostris under different climate change scenarios. The model also predicts potentially suitable habitats for P. flavirostris outside of its current range, suggesting areas where the species may expand or contract its distribution in the future. This research provides valuable insights into the habitat suitability and potential range dynamics of P. flavirostris, and can inform conservation planning and management efforts for this threatened bird species.
Efforts to Prevent Hypertension in The Kaili Tribe Community
Authors: Mustaqima  , Thaha Ridwan Mochtar , Syafar Muhammad 
Published: June 2024

Background: Hypertension causes many risks of premature death. The increase in hypertension sufferers in Palu City continues to fluctuate every year, the latest data for 2022 is that the number of hypertension sufferers is 7,848 cases and is in first place on the list of the highest non-communicable diseases. Based on medical record reports from the community health center, most of those suffering from hypertension complications from Kaili ethnic backgrounds are caused by lifestyle. Objective: This study aims to analyze efforts to prevent hypertension in the Kaili tribe community. Method: The type of research is qualitative research with an ethnographic approach. Data collection using independent interviews and observations. The research informants were 12 informants who were determined using the snowball sampling technique. Results: The research results show that the Kaili tribe community accepts health values in preventing hypertension through health activities such as Posbindu PTM and Sehat Friday, involving various parties. The general health protection norm is 5-30 minutes of light to heavy physical activity every day. The culture of consuming local fruit, such as bananas, is still strong with an average of 1-2 fruits per day, but the pattern of vegetable consumption is good even though there is an inappropriate habit of cooking vegetables with coconut milk. Routine health checks are carried out 1-3 times a month, including general examinations, blood pressure, blood sugar, urine and counseling. Conclusion: Suggestions for the Kaili tribe community to actively participate in health programs, so that they are aware, independent and able to avoid hypertension from an early age.
Entrepreneurial Resilience During COVID-19: The Survival of Small Businesses Using Dynamic Capabilities Theory and Effectuation Theory
Authors: Xueyun Zhong , Yongyu Lu , Hizam-Hanafiah Mohd , Yazid Zaleha , Muhamad Nur Saadah 
Published: June 2024

Objectives: This study explores how Bali's sport tourism stakeholders used dynamic capabilities to mitigate COVID-19's impacts. Given Bali's reliance on sport tourism, understanding recovery is crucial. The research aims to identify pandemic challenges, explore strategic recovery plans, and understand how entrepreneurs leverage dynamic capabilities for survival and growth.

Theoretical Framework: The study integrates dynamic capabilities and effectuation theories with entrepreneurial resilience. Dynamic capabilities involve adapting, learning, and transforming activities to meet changing environments. Effectuation theory focuses on leveraging available means and making decisions based on emerging opportunities. Together, these theories offer a comprehensive understanding of adaptation strategies among Bali's sport tourism entrepreneurs.

Method: Using a qualitative design, the research conducts semi-structured interviews with 10 small and medium-sized enterprises (SMEs) in Bali's sport tourism sector.

Results and Discussion: Findings highlight resilience's role in fostering adaptability, motivation, and a learning mindset. An activity-based model for dynamic capabilities focuses on integration, learning, and transformation with employee and customer involvement. Leveraging dynamic capabilities, assessing opportunities with available means, and using innovative technologies are crucial for strategic decisions in uncertain environments.

Research Implications: This study contributes to the entrepreneurship and strategic management literature. Integrating dynamic capacities, effectuation theories, and entrepreneurial resilience provides useful insights for academics, policymakers, and practitioners. The work offers practical solutions for resilience in dynamic contexts.

Originality/Value: This study enhances understanding of how Bali’s sport tourism entrepreneurs adapt to a transformed entrepreneurial ecosystem. It serves as a valuable resource for developing resilient strategies for future disruptions.
The Moderating Effect of Gender Diversity on the Relationship Between Corporate Governance and Company Performance: Findings from the Tunisian Stock Exchange
Authors: Mahfoudh Slim , Abdallah Takwa , Gaf Estabrak Ismael Hama Murad Al 
Published: June 2024

Purpose: This research aims to argue that the inconclusive evidence of the relationship between corporate governance and performance may be due to the moderating effect of gender diversity on the board.

Design/methodology/approach: The study is based on a sample of 16 companies listed on the Tunisian Stock Exchange (BVMT) over the period 2009-2021. A moderating regression analysis inspired this research.

Findings: Specifically, corporate governance appears to have a positive effect on firm performance only in countries with above-average board diversity. The effect of corporate governance on performance decreases as board diversity decreases. The results are robust to different measures of board gender diversity and firm performance, changes in estimation methods, changes in sample structure, and tokenism.

Originality/value: This article extends the existing literature by examining the moderating effect of gender diversity on boards of directors on the relationship between corporate governance and firm performance.
High School Students’ Academic Performance Concerning Social Responsibility and Self-Efficacy
Authors: Shala Diana Sejdiu , Kurhasku Andrita , Rexhepi Rita 
Published: June 2024

Objective: This study aims to examine whether a correlation exists among academic performance, social responsibility, and self-efficacy, as all three elements play a crucial role in an individual's development and maturation.

Theoretical Framework: The study was focused on the relationship between social responsibility, self-efficacy, and academic performance. Furthermore, it analyzed differences based on age and gender in the scale of these variables.

Method: The research was conducted with a champion of 100 students aged 15 to 19. To measure these variables two reliable assessments have been used. Data collection was carried out through questionnaires.

Results and Discussion: The findings of this study reveal a minimal correlation between social responsibility and self-efficacy, shedding light on the prevailing circumstances faced by the students. Additionally, the results indicate an absence of statistically significant gender disparities in these factors while highlighting age-related distinctions in self-efficacy levels.

Research Implications: The practical and theoretical implications of this research are discussed, providing insights into how the results can be applied or influence practices in the field of psychology and education. [insert field of study]. These implications could encompass education curricula and student awareness of important psychological and social issues.

Originality/Value: This article encourages further research, educational curriculum modifications, and professional framework building. Moreover, the study suggests raising awareness for social responsibility and the need to provide knowledge and practice about social issues.
Factors Influencing Female User’s Satisfaction in Mobile Banking: A Study in Manipur, India
Authors: Singh Palungbam Lerix , Singh Kshetrimayum Ranjan , Singh Professor Nongmaithem Tejmani 
Published: June 2024

Objective: This empirical study is aimed at investigating the impact of perceived credibility, perceived self-expressiveness, social norms and perceived compatibility on the mobile banking user’s satisfaction amongst the female population of Manipur, India.

Theoretical Framework: Using Technology Acceptance Model (TAM) as the basic framework, this study focuses on several constructs and their impact on user’s satisfaction of mobile banking users, namely, perceived credibility (PC), perceived self-expressiveness (PSE) and social norms (SN).

Method: The study employed structural equation modeling to test the proposed model, which was based on statistical data obtained from a survey of 202 respondents from 2 districts of Manipur, India. Consequently the EFA, CFA, discriminant and convergent validity of the items has also been tested.

Results and Discussion: The study revealed that perceived self-expressiveness, social norms, and perceived compatibility has a significant positive impact on the user’ satisfaction among female mobile banking users. However, perceived self-expressiveness seems to have a negative impact on the user’s satisfaction, implying as the perceived self-expressiveness increase the satisfaction of using mobile banking service decreases.

Implications: These findings provide valuable insights for the mobile banking service providers, highlighting the significance of credibility, social norm and compatibility in improving user satisfaction and also informing strategies for improving mobile banking experiences among female population.

Originality/Value: The research enlarges on the theory of TAM expanding its scope to various dimensions like perceived self-expressiveness, social -norms and its originality lies on the focus on females respondents only, from a northeastern state of India i.e. Manipur.
Cultural Sustainability: Reflections on The Social Formation of Panambi/RS in The Light of Lutheranism
Authors: Hardt Jeferson Grosse , Oliveira Tarcisio Dorn de , Muller Airton Adelar , Silveira Daniel Claudy da , Chagas Daniel Hedlund Soares das , Mantei Anderson 
Published: June 2024

Objective: The objective of this study is to understand German colonization in Panambi, a city located in the Northwest of the State of Rio Grande do Sul, by understanding it as a complex process that involves a variety of historical, economic, social, political and cultural factors of varied dimensions that intertwine to shape the unique character of the city in the light of Lutheranism.

Theoretical Framework: Protestantism played a significant role in the formation of the developmental spirit in the South of Brazil, particularly in the 19th and early 20th centuries. The Colonies in the South of Brazil and Lutheranism are deeply interconnected, mainly through German immigration, given that these immigrants brought with them cultural, religious and social practices that significantly shaped the region.

Method: The research follows methodological paths of an applied nature and a qualitative approach. Regarding procedures, a bibliographic review, documentary research and case study are used. Data interpretation is anchored in categorical content analysis.

Results and Discussion: The research results point to local development, the emergence of companies, with community ties strengthening the tripod: religion, school and work. A process of cultural identification in the municipality had strong German influences, from the religious Lutheranism, focused on the world of work. This journey contributed to the strengthening and dissemination of a social imaginary that reinforces the relationship between colonization and the Lutheran Church, and, associated with it, the school, which sustains and preserves German culture, generating “Germanness”. Thus, this peculiarity lived and experienced by the social agents who colonized Panambi, created a social system that, although in constant adaptation, maintains the relationship between Germanness, church, entrepreneurship to boost local development.

Originality/Value: This study contributes to the literature by addressing the sociocultural formation of the city of Panambi, given that this development shapes the unique characteristics of the city, influencing its growth, urban structure, social dynamics and cultural identity.
Maturity Stage of ESG (Environmental, Social and Governance) Practices in Hosting Operations Using the MATESG-H Tool
Authors: Oliveira Franco Marcelo de , Mecca Marlei Salete , Eckert Alex , Pioner Anelise 
Published: June 2024

Objective: This study aims to utilize the MATESH-H tool (Oliveira, 2024) to assess the implementation stage of ESG criteria in accommodation operations within Brazilian tourist destinations.

Method: The methodology adopted is qualitative and descriptive. We conducted a case study on accommodation in a tourist destination in the state of Rio Grande do Sul, Brazil.

Results and discussion: The strategic organization was strategic in the maturity stage 3 (Management), in addition to already having structured processes and significant involvement with ESG principles, going beyond legal obligations. However, the environmental axis was identified as the weak point, being at the lowest level of maturity. This highlights the need to focus efforts on improving environmental practices to achieve systemic evolution.

Research Implications: The research suggests that understanding current positioning relative to ESG criteria is crucial for guiding strategic planning and establishing realistic goals for improvement. The application of the MATESG-H tool can contribute to the integration of sustainable practices in accommodation operations and systemically improve hotel management.

Originality/Value: This study contributes by highlighting the importance of applying the MATESG-H tool in assessing the level of ESG maturity. In addition to providing relevant information for managers, the research enriches academic, political, and business debates about ESG, encouraging new research and providing performance indicators that are more aligned with the informational needs of organizations.
If there's Relation between Malaria and COVID -19
Authors: Erzaiq Zainab S. 
Published: June 2024

Malaria is a parasitic infection, caused by parasites of the genus Plasmodium and transmitted by Anopheles mosquitoes, that leads to an acute life-threatening disease and poses a notable global health threating . According to the World Health Organization (WHO) data of 2019, about 228 million cases of malaria and 405,000 deaths were reported worldwide.Due to the similarity of symptoms between malaria and COVID-19, especially fever, difficulty in breathing, fatigue and headache of acute onset, a malaria patient may be misdiagnosed as COVID-19 and vice versa. Moreover, complications like acute respiratory distress syndrome (ARDS), septic shock, and multi-organ failure can also happen in both malaria and COVID-19. The first step to identify a COVID-19 patient is the symptomatic screening, which consists of shortness of breath, fever, dry cough, sore throat, headache and myalgia in a high-risk patient like healthcare workers or patients with a history of contact with a confirmed COVID-19 case.Some scientists attribute the inverse relationship between COVID 19 and malaria to the wide use of hydroxychloroquine (HCQ), chloroquine (CQ) and other anti-malarial drugs in countries that are endemic for malaria. In conclusion, COVID-19 has a variable prevalence among countries which is lower than expected in malaria-endemic regions. In addition to the possible role of health infrastructure and mitigation tools adopted, Both hydroxychloroquine (HCQ) and chloroquine (CQ) may have preventive and curative effects against SARS-CoV-2 virus through different mechanisms, however, clinical trials are still investigating the use of these medications as a potential treatment and preventive measures. The lower than expected number of cases detected in Asia suggests that the young age structure may be protective of severe and thus detectable cases.
Aktivitas Biofungisida Ekstrak Daun Jarak Pagar (Jatropha curcas L.) terhadap Pertumbuhan Fusarium sp. secara In Vitro
Authors: Titalianingtyas Elva , Ratnasari Evie 
Published: June 2024

Fusarium sp. merupakan patogen yang menyebabkan penyakit layu pada hasil pertanian terutama tanaman hortikultura. Penanggulangan Fusarium sp. menggunakan fungisida sintetis berdampak negatif bagi ekosistem dan kesehatan makhluk hidup di sekitarnya, sehingga dibutuhkan biofungsida alternatif. Daun jarak pagar (Jatropha curcas L.) berpotensi sebagai biofungisida karena mengandung senyawa flavonoid, alkaloid, saponin, tanin, fenol, dan steroid. Penelitian ini bertujuan untuk mengetahui aktivitas biofungisida ekstrak daun jarak pagar serta konsentrasi yang optimal dalam menghasilkan penghambatan pertumbuhan Fusarium sp. Rancangan acak lengkap digunakan dalam penelitian ini dengan 7 perlakuan dan 4 pengulangan. Konsentrasi ekstrak yang digunakan sebesar 60%, 70%, 80%, 90%, 100%, serta kontrol positif menggunakan fungisida sintetis berbahan aktif propineb 70%, dan kontrol negatif (tanpa perlakuan). Pengukuran diameter koloni Fusarium sp. dan persentase daya hambat ekstrak dilakukan pada hari ke-7 inkubasi. Data dianalisis secara statistik untuk mengetahui perbedaan antar perlakuan. Hasil penelitian menunjukkan adanya aktivitas penghambatan ekstrak dalam menghambat pertumbuhan Fusarium sp. secara in vitro. Konsentrasi optimal ditunjukkan pada konsentrasi 90% dengan rata-rata pertumbuhan 5,08 ± 0,83 cm dan rata-rata persentase daya hambat 43,5 ± 9,11 %. Dari hasil tersebut dinyatakan bahwa ekstrak daun jarak pagar berpotensi sebagai biofungisida dalam menghambat pertumbuhan Fusarium sp. secara in vitro.