bluuebunny/crossref_metadata_2025_split huggingface dataset:
Anti-inflammatory and/or immunomodulatory activities of Uncaria tomentosa (cat’s claw) extracts: A systematic review and meta-analysis of in vivo studies
Authors: Arado Gustavo Marin , Amatto Pedro de Padua G. , Marins Mozart , Rizzi Elen Sanchez , França Suzelei de Castro , Coppede Juliana da Silva , Carmona Fábio , Pereira Ana Maria Soares 
Published: May 2024

BackgroundUncaria tomentosa (Willd. ex Schult.) DC. (Rubiaceae) is traditionally used by Amazonian indigenous groups to treat inflammatory diseases. To date, there are no systematic reviews and meta-analyses on the use of U. tomentosa for inflammation control in animals supporting the traditional knowledge about this species. This study was conducted to evaluate the effect of U. tomentosa extracts in modulating inflammatory mediators and to determine which types of inflammatory diseases can be treated by this species.MethodsWe conducted a systematic review and meta-analysis of preclinical studies published before 26 July 2023, identified in PubMed, Embase, and Scopus. Four independent reviewers extracted the data and assessed the risks of bias. The effects of U. tomentosa on inflammatory diseases and the inflammatory mediators involved were extracted from the studies. Standardized mean differences (SMD) and 95% confidence intervals (95%CI) of the outcomes were estimated. The meta-analyses were conducted using RevMan 5.4 (Cochrane Collaboration). This protocol was registered in PROSPERO (CRD42023450869).ResultsTwenty-four of 523 studies were included. U. tomentosa extracts decreased the cytokines interleukin (IL)-6 (SMD: −0.72, 95%CI: −1.15, −0.29, p = 0.001) and transcription factor nuclear factor kappa-B (NF-κB) (SMD: −1.19, 95%CI: −1.89, −0.48, p = 0.001). However, the extracts did not significantly alter IL-1 (SMD: −0.16, 95%CI: −0.87, +0.56, p = 0.67), IL-10 (SMD: −0.05, 95%CI:–0.35, 0.45, p = 0.80), or tumor necrosis factor-alpha (TNF-α) levels (SMD: 0.18, 95%CI: −0.25, 0.62, p = 0.41).ConclusionMany extracts of stem bark, roots, and leaves of U. tomentosa, mostly aqueous and hydroethanolic, exhibited anti-inflammatory and/or immunomodulatory activities and low toxicity. The extracts decreased NF-κB and IL-6. These findings suggest that this species has the potential to treat inflammatory diseases in which these markers are increased, according to the ethnopharmacological use. These activities are not related to a specific class of compounds.Systematic Review Registration:https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=450869, Identifier CRD42023450869.
Utility of Faster R-CNN in methodological comparison and evaluation of reticulocytes
Authors: Sun Shengli , Wang Geng , Zhang Binyao , Wang Fei , Wu Wei 
Published: May 2024

ObjectiveThe purpose of this study was to evaluate the methodological comparison of reticulocytes by using the intelligent learning system Faster R-CNN, a set of reticulocyte image detection systems developed using deep neural networks.MethodsWe selected 59 EDTA-K2 anticoagulated whole blood samples and calculated the RET% using seven different Sysmex XN full-automatic hematology analyzers with Faster R-CNN in the laboratory. We compared and evaluated the methods and statistically analyzed the correlation between the various test results.ResultsThe results indicated a high degree of consistency between the seven Sysmex XN full-automatic hematology analyzers and Faster R-CNN in detecting RET%. The correlation coefficients were 0.987, 0.984, 0.986, 0.987, 0.987, 0.988, and 0.986, respectively.ConclusionWe found that the Sysmex XN full-automatic hematology analyzers in our laboratory using the Faster R-CNN system met the requirements of the methodological comparison of reticulocyte detection and this intelligent learning system can be a useful clinical tool.
Latitudinal patterns and their climate drivers of the δ13C, δ15N, δ34S isotope signatures of Spartina alterniflora across plant life-death status: a global analysis
Authors: Zhang Dongjie , Wang Hui , Liu Xuepeng , Ao Kang , He Wenjun , Wang Tongxin , Zhang Mingye , Tong Shouzheng 
Published: May 2024

Isotopic signatures offer new methods, approaches, and perspectives for exploring the ecological adaptability and functions of plants. We examined pattern differences in the isotopic signatures (δ13C, δ15N, δ34S) of Spartina alterniflora across varying plant life-death status along geographic clines. We extracted 539 sets of isotopic data from 57 publications covering 267 sites across a latitude range of over 23.8° along coastal wetlands. Responses of isotopic signatures to climate drivers (MAT and MAP) and the internal relationships between isotopic signatures were also detected. Results showed that the δ13C, δ15N, and δ34S of S. alterniflora were -13.52 ± 0.83‰, 6.16 ± 0.14‰, and 4.01 ± 6.96‰, with a range of -17.44‰ to -11.00‰, -2.40‰ to 15.30‰, and -9.60‰ to 15.80‰, respectively. The latitudinal patterns of δ13C, δ15N, and δ34S in S. alterniflora were shaped as a convex curve, a concave curve, and an increasing straight line, respectively. A decreasing straight line for δ13C within the ranges of MAT was identified under plant life status. Plant life-death status shaped two nearly parallel decreasing straight lines for δ34S in response to MAT, resulting in a concave curve of δ34S for live S. alterniflora in response to MAP. The δ15N of S. alterniflora significantly decreased with increasing δ13C of S. alterniflora, except for plant death status. The δ13C, δ15N, and δ34S of S. alterniflora are consistent with plant height, stem diameter, leaf traits, etc, showing general latitudinal patterns closely related to MAT. Plant life-death status altered the δ15N (live: 6.55 ± 2.23‰; dead: -2.76 ± 2.72‰), latitudinal patterns of S. alterniflora and their responses to MAT, demonstrating strong ecological plasticity and adaptability across the geographic clines. The findings help in understanding the responses of latitudinal patterns of the δ13C, δ15N, and δ34S isotope signatures of S. alterniflora in response plant life-death status, and provide evidence of robust ecological plasticity and adaptability across geographic clines.
Regulating root structure of potted lettuce to magnify absorption from APP and UAN fertilizers
Authors: Li Changqing , Li Yahao , Yang Jungang , Lian Bingrui , Wang Jiqing , Zou Guoyuan 
Published: May 2024

IntroductionImprovement of root architecture is crucial to increasing nutrient acquisition.MethodsTwo pot experiments were conducted to investigate the effects of different concentrations of urea ammonium nitrate solution (UAN) and ammonium polyphosphate (APP) on lettuce root architecture and the relationship between roots and nitrogen (N) and phosphorus (P) absorption.ResultsThe results showed that lettuce yield, quality, and root architecture were superior in the APP4 treatment compared to other P fertilizer treatments. The N480 treatment (480 mg N kg-1 UAN) significantly outperformed other N treatments in terms of root length, root surface area, and root volume. There were significant quantitative relationships between root architecture indices and crop uptake of N and P. The relationships between P uptake and root length and root surface area followed power functions. Crop N uptake was significantly linearly related to the length of fine roots with a diameter of &lt;0.5 mm.Conclusion and discussionThe length of fine roots played a more prominent role in promoting N absorption, while overall root size was more important for P absorption. APP has a threshold of 9.3 mg P kg-1 for stimulating the root system. Above this threshold, a rapid increase in root absorption of P. UAN can promote extensive growth of fine roots with a diameter less than 0.5 mm. Applying appropriate rates of APP and limiting UAN application to less than 400 mg N kg-1 can improve root architecture to enhance N and P absorption by lettuce. These results highlight a new possibility to improve nutrients use efficiency while maintaining high yields.
Deep transcranial magnetic stimulation for schizophrenia: a systematic review
Authors: Mo Yu , Shi Zhan-Ming , Yang Xin-Hu , Lan Xian-Jun , Deng Can-Jin , Huang Xing-Bing , Tan Xiao-Lin , Pridmore Saxby , Ungvari Gabor S. , Xiang Yu-Tao , Zheng Wei 
Published: May 2024

BackgroundThe efficacy and safety of deep transcranial magnetic stimulation (dTMS) as an intervention for schizophrenia remain unclear. This systematic review examined the efficacy and safety of dTMS for schizophrenia.MethodsA systematic search of Chinese (WanFang and Chinese Journal Net) and English databases (PubMed, EMBASE, PsycINFO, and Cochrane Library) were conducted.ResultsThree randomized clinical trials (RCTs) comprising 80 patients were included in the analyses. Active dTMS was comparable to the sham treatment in improving total psychopathology, positive symptoms, negative symptoms, and auditory hallucinations measured by the Positive and Negative Syndrome Scale (PANSS), the Scale for the Assessment of Positive Symptoms (SAPS), the Scale for the Assessment of Negative Symptoms (SANS), and the Auditory Hallucinations Rating Scale (AHRS), respectively. Only one RCT reported the effects on neurocognitive function measured by the Cambridge Neuropsychological Test Automated Battery (CANTAB), suggesting that dTMS may only improve one Stockings of Cambridge measure (i.e., subsequent times for five move problems). All three studies reported overall discontinuation rates, which ranged from 16.7% to 44.4%. Adverse events were reported in only one RCT, the most common being tingling/twitching (30.0%, 3/10), head/facial discomfort (30.0%, 3/10), and back pain (20.0%, 2/10).ConclusionThis systematic review suggests that dTMS does not reduce psychotic symptoms in schizophrenia, but it shows potential for improving executive functions. Future RCTs with larger sample sizes focusing on the effects of dTMS on psychotic symptoms and neurocognitive function in schizophrenia are warranted to further explore these findings.
Unveiling the occurrence of COVID-19 in a diverse Bangladeshi population during the pandemic
Authors: Hossain Mahmud , Mannan Rezowana , Islam Sohidul , Banu Laila A. , Jamee Ahsan Rahman , Hassan Zahid , Elias Sabrina Moriom , Das Sanjan K. , Azad Khan A. K. 
Published: May 2024

IntroductionCOVID-19 pandemic hit Bangladesh with relatively low intensity, unlike its neighbors India and European countries and USA.MethodsThe present report included data of 8,480 individuals tested for COVID-19 RT-PCR of the workers and officials from readymade garments (RMG) industry in Chandra area in Gazipur. The present data looked into the clinic-demographic factors associated with the susceptibility of the condition.ResultThe data elucidated the susceptibility of the individuals to SARS-CoV-2 based on age, gender, pre-existing health conditions, and the presence of symptoms. It was observed that individuals aged over 60 had the highest rate of COVID-19 positivity, and men exhibited a higher infection rate compared to women. Regardless of age, fever and cough were the most frequently reported symptoms. Two-thirds of the individuals included in this report appeared to be asymptomatic carriers. The prevalence of comorbidities among individuals who tested positive for COVID-19 was notably higher, and this exhibited a gender-specific pattern.DiscussionAlthough our study provides important epidemiological insights into the initial year of the pandemic among Bangladeshi populations, it can also add value for future drug and vaccine development. However, it is essential to acknowledge the limitations like - restriction of public movement, unavailability of vehicle yielding a selection bias, due to the lockdown conditions imposed owing to the pandemic and the diverse characteristics of the participants. The report emphasizes the significance of figuring out how age, gender, and underlying health conditions impact susceptibility to and transmission of COVID-19, thereby providing valuable insights for public health strategies and future research initiatives.
Identification of specific recommendations for prehospital stroke care associated with shorter door-to-CT times – An analysis of Get with the Guidelines-Stroke registry and prehospital data
Authors: Dylla Layne , Higgins Hannah M. , Wham Courtney D. , Leppert Michelle , Ravare Brandy C. , Jeppson Kerri A. , Bina Heather T. , Monte Andrew A. , Poisson Sharon N. 
Published: May 2024

ObjectiveFull compliance with American Heart Association (AHA) recommendations for prehospital care of stroke patients remains low. This study aims to identify components of prehospital care associated with shorter door-to-computed tomography (CT) times.MethodsData from a comprehensive stroke center's Get with the Guidelines-Stroke registry were supplemented by prehospital medical records for ischemic stroke patients between January 1, 2018, and December 31, 2020. Descriptive statistics and multivariable linear regression modeling was used to evaluate door-to-CT times for encounters compliant with AHA recommendations.ResultsThere were 621 ischemic stroke patients who presented via a prehospital provider, 452 of whom presented from the scene. Without adjusting for potential confounders, shorter door-to-CT times were observed with emergency medical services' documentation of a last-known well time, measurement of a blood glucose level, prenotification of a suspected stroke, or full compliance with AHA recommendations. Documentation of classic stroke signs, but not of a prehospital stroke scale, was also observed to have shorter door-to-CT times compared to encounters in which this did not occur.ConclusionDuring prehospital care of stroke, documentation of classic symptoms, obtaining a last-known well time or time of symptom onset, obtaining a blood glucose level, prenotifying the receiving hospital of suspected stroke, and complying fully with guidelines are associated with shorter door-to-CT times. Further studies are needed to understand if a shift in prehospital provider education, focusing on these key components of care, could lead to earlier diagnosis and treatment of acute stroke.
Impact of Long-Term Supplementation with Probiotics on Gut Microbiota and Growth Performance in Post-Weaned Piglets
Authors: Park Soo-Yeon , Kim Yo-Han , Kim Sung-Jae , Han Jeong-Hee 
Published: May 2024

This study aimed to investigate effects of long-term probiotic supplementation on gut microbiota and growth performance in health weaned piglets. The non-probiotic group (N-PrB) was fed only a basal diet, while the probiotic group (PrB) was fed a basal diet + probiotic combination (E. faecium 1.6 × 108 CFU/g, B. subtilis 2.0 × 108 CFU/g, S. cerevisiae 3.0 × 108 CFU/g). The probiotics combination was provided to the PrB, mixing with the basal diet in 5 kg/ton. As a result, the PrB exhibited significantly improved weight gain compared to the N-PrB (p = 0.00991). In the gut microbiome analysis, the PrB exhibited a significant increasing tendency of α-diversity compared to those of the N-PrB (p < 0.01). In the bacterial relative abundance changes in bacteria comprising the gut microbiota, Ruminococcaceae (p = 0.00281) and Prevotella (p = 0.00687) tended to significantly increase in the PrB, but decreased in the N-PrB. The Eubaterium coprostanoligenes group exhibited an increasing tendency in both groups, but tended to increase more significantly in the PrB compared to the N-PrB (p = 0.00681). Muribaculaceae tended to significantly increase in the N-PrB, but decreased in the PrB (p = 0.002779). In this study, significant differences on the gut microbiome were found according to the probiotics supplementation in the weaned piglets and these gut microbiome changes appeared to improve the growth performance.
Clinical and Functional Effects of Rehabilitation of Patients after COVID-19 Infection
Authors: Dzięcioł-Anikiej Zofia , Kuryliszyn-Moskal Anna , Pociene Monika , Dzięcioł Janusz , Dakowicz Agnieszka , Kostro Amanda 
Published: May 2024

Abstract: Background/Objectives: The most common post-acute consequences of SARS-CoV-2 include lung dysfunction, the impairment of cognitive functions and mental health, as well as the impairment of the musculoskeletal system in the form of fatigue and muscle weakness. Post-COVID-19 patients often experience impaired balance and reduced physical capacity. It is important to implement a rehabilitation program that eliminates the side effects of COVID-19 and allows for significant improvement in the patient’s functionality. The aim of our study was to assess patient functionality after a 6-week rehabilitation program on balance, foot pressure distribution, and physical capacity in post-COVID-19 patients. Methods: The clinical study group consisted of 53 people 3 months after COVID-19 infection, confirmed by a positive PCR test. Exclusion from the study included people with comorbidities that impaired balance and gait. The patients underwent a posturographic assessment—Romberg test, a baropodometric assessment—static and dynamic, and a performance assessment—a 6 min walk test determining shortness of breath on the mMRC scale, blood pressure, heart rate, and saturation. Patients participated in rehabilitation until the sixth week, after which they were assessed again. Comparisons were made using IBM SPSS Statistics 27.0 software using the Wilcoxon pairwise order test, at a significance level of p < 0.05. Results: The result of the postural control assessment showed an improvement in the ability to maintain the centre of gravity in terms of the foot support area—statistical decreases were observed in the ellipse area, from 745.28 mm2 to 453.52 mm2 (p = 0.009), as well as maximum (from 3133.5 gr/cm2 to 2994.2 gr/cm2; p = 0.065) and average load on the left foot (from 1010.1 gr/cm2 to 969.38 gr/cm2; p = 0.028). In the 6 min walk test before and after exercise, the heart rate decreased after the therapy (shortness of breath on the mMRC scale also decreased from 79.12 to 74.95). This means that patients achieved better physical fitness and efficiency. Conclusions: Rehabilitation significantly improved balance, as measured by a decrease in ellipse area during the Romberg test.
Comparison of Tetraselmis suecica Cell Disruption Techniques: Kinetic Study and Extraction of Hydrosoluble Compounds
Authors: Rida Hussein , Peydecastaing Jérôme , Takache Hosni , Ismail Ali , Pontalier Pierre-Yves 
Published: May 2024

The optimization of cell disruption is a critical step in microalgal biorefineries. We used the same batch of Tetraselmis suecica culture to compare two mechanical cell disruption techniques, focusing on the extraction yield of water-soluble molecules. The conditions for high-pressure homogenization (HPH) studied were two passes at a moderate pressure of 300 bars. For ultrasound (US) treatment, we used an amplitude of 20% (equivalent to 100 W) for 25 min. These conditions were chosen on the basis of a preliminary screen of extraction conditions. HPH extracted proteins and pigments more efficiently than US, whereas US was superior for uronic acid extraction. Interestingly, the two methods had similar extraction yields for carbohydrates under the studied conditions. We also analyzed the kinetics of molecule release by considering the centrifugation time lag for HPH and applying a first-order kinetic model for US. HPH outperformed US in terms of the immediate extraction and release of molecules.
Comprehensive approaches to child development in islamic law
Authors: Kaas Al-Hawary , Birdsall Dubis Bhutta , Aziz Hossain 
Published: May 2024

This research examines comprehensive approaches to child development within the framework of Islamic law, synthesizing findings from a range of studies published in the last two decades. The review explores the multifaceted nature of child development across financial, educational, moral, emotional, and spiritual dimensions within Islamic contexts. Key findings highlight the significance of parental responsibilities in providing for children's basic needs, ensuring equitable inheritance, and investing in both religious and secular education. Moreover, the review underscores the critical role of moral and religious upbringing in shaping children's character and behavior, fostering values such as integrity, compassion, and social responsibility. Emotional and psychological support emerge as essential components of child development, promoting resilience, self-esteem, and emotional well-being. Additionally, the review examines the importance of preparing children for adulthood by instilling practical skills, ethical values, and a strong sense of responsibility. The synthesis of findings underscores the holistic approach advocated by Islam, which prioritizes the well-rounded development of children within a framework of justice, equity, and compassion. The review provides valuable insights for parents, educators, policymakers, and researchers in promoting the holistic well-being of children within Islamic contexts.

Research Highlights:

Intersection of Religious and Secular Education: The research elucidates the intersectionality of religious and secular education within Islamic contexts, emphasizing the importance of integrating both domains to foster well-rounded individuals capable of navigating the modern world while upholding Islamic values.
Ethical Financial Planning: The research underscores the significance of adhering to Sharia principles in financial planning for children, highlighting the ethical imperative of ensuring halal income and investments to promote financial stability and spiritual well-being.
Parental Intentions (Niyyah): The role of parental intentions (niyyah) emerges as a key factor in fulfilling obligations towards children, emphasizing the importance of sincerity and devotion in nurturing children within an Islamic framework.
Justice and Equity: Islamic principles of justice and equity profoundly influence parental responsibilities, emphasizing the fair and equitable treatment of children in all aspects of upbringing, including financial provision, education, and discipline.
EDUKASI DAN SIMULASI PENANGANAN KORBAN GAWAT DARURAT HENTI JANTUNG PREHOSPITAL PADA MASYARAKAT AWAM
Authors: Sayuti Solihin , Fahmi Ismail , Suryaman Ade 
Published: May 2024

Latar Belakang: Out-of-Hospital Cardiac Arrest (OHCA) merupakan penyebab kematian terbesar pada pasien serangan jantung. Kejadian serangan jantung di luar rumah sakit memiliki harapan untuk hiduo sangat rendah, serta di tunjang layanan gawat darurat terpadu yang kurang baik, sehingga menjadikan kesempatan hidup penderita sangat kecil, sehingga perlu untuk membentuk orang yang mampu melakukan bantuan hidup dasar (Bystander CPR) di komunitas. Pengabdian Masyarakat ini bertujuan untuk memberikan edukasi dalam memberikan bantuan hidup dasar. Metode: Pelatihan pemberian bantuan hidup dasar pada 40 partisipandengan mengunakan metode ceramah, tanya jawab, demonstrasi serta simulasi, pelaksanaan pengabdian dilakukan sebanayk 2 kali ( edukasi dan simulasi). Penilaian kemampuan peserta menggunakan kuisioner yang terdiri 10 pertanyaan pilihan ganda. Hasil: hasil pengabdian masyarakat didapatkan data 90% partisipan adalah perempuan, terjadi perbedaan rerata pengetahuan partisipan sebelum dan setelah edukasi simulasi Pa value 0,0001 (CI 95%)Kesimpulan: Dengan dilakukannya pelatihan Bantuan Hidup Dasar dapat meningkatkan pengetahuan dan kemampuan partisipan dalam menolong kegawatan jantung..