bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association between Job Stress and Insomnia in Korean Workers
Authors: Kim Hwan‐Cheol , Kim Byeong‐Kwon , Min Kyoung‐Bok , Min Jin‐Young , Hwang Sang‐Hee , Park Shin‐Goo 
Published: March 2011

Association between Job Stress and Insomnia in Korean Workers: Hwan‐Cheol Kim, et al. Department of Occupational and Environmental Medicine, Inha University Hospital, Korea—ObjectiveWe investigated the association between job stress and insomnia in a large nationwide samples of Korean workers.MethodsIn this cross‐sectional study, a total of 8,155 workers from a nationwide sample were recruited. We surveyed the subjects' sociodemographic and work‐related characteristics and seven subscales of occupational stress using the Korean Occupational Stress Scale Short Form. Each subscales of job stress was dichotomized into higher or lower group by respective median scores. Insomnia was deined as having at least one of the three sleep symptoms. we performed multivariate logistic regression analysis to identify association between job stress and insomnia.ResultsWe found that individuals with relatively high job stress experienced insomnia significantly more frequently, and the significance was maintained even after adjustment for confounding variables(high job demand: OR: 1.30, 95% CI: 1.14– 1.47; insuficient job control: OR: 1.13, 95% CI: 0.99– 1.29; inadequate social support: OR: 1.30, 95% CI: 1.14–1.47; job insecurity: OR: 1.25, 95% CI: 1.11–1.44; organizational injustice: OR: 1.27, 95% CI: 1.12–1.44; lack of reward: OR: 1.18, 95% CI: 1.04–1.34; discomfort in occupational climate: OR: 1.38, 95% CI: 1.22–1.57; total job stress: OR: 1.45, 95% CI: 1.28–1.64).ConclusionThis study suggested that job stress is possible risk factor for insomnia and that particularly discomfort in occupational climate and inadequate social support have more strong relation to insomnia in Korea.
Lack of Survival Gain for Elderly Women with Breast Cancer
Authors: Bastiaannet Esther , Portielje Johanneke E.A. , Velde Cornelis J.H. , Craen Anton J.M. , Velde Susanne , Kuppen Peter J.K. , Geest Lydia G.M. , Janssen-Heijnen Maryska L.G. , Dekkers Olaf M. , Westendorp Rudi G.J. , Liefers Gerrit-Jan 
Published: March 2011

Abstract

Background.
The number of elderly women with breast cancer is increasing and will become a major health concern. However, little is known about the optimal treatment for this age group. The aim of this study was to describe time trends for the overall Dutch breast cancer cohort with an emphasis on differences between young and elderly patients.

Methods.
All adult female patients diagnosed in 1995–2005 were selected from the Netherlands Cancer Registry. Relative excess risks for death (adjusted for stage, histology, treatment, and grade) were estimated using a multivariate generalized linear model with a Poisson distribution, based on collapsed relative survival data, using exact survival times.

Results.
Overall, 127,805 patients were included. Treatment of patients aged ≥75 years changed significantly over time: they received less surgery, more adjuvant hormonal treatment and chemotherapy, and more hormonal treatment without surgery. In contrast to younger patients, the relative survival did not improve significantly over time for elderly patients. With increasing age, the observed–expected death ratio decreased to almost 1.0.

Conclusion.
Survival for elderly patients with breast cancer did not improve significantly. Observed–expected death ratios in the elderly are close to 1, indicating that excess mortality is low. Elderly patients with breast cancer have a higher risk for overtreatment and undertreatment, with a delicate therapeutic balance between breast cancer survival gain and potential toxicities. To improve breast cancer survival in the elderly, a critical reappraisal is needed of costs and benefits of hormonal as well as other treatments, and better selection of patients who can benefit from available therapies is warranted.
Periacetabular Osteotomy in Patients Fifty Years of Age or Older
Authors: Teratani Takeshi , Naito Masatoshi , Kiyama Takahiko , Maeyama Akira 
Published: March 2011

BACKGROUND:
Periacetabular osteotomy has been established as an effective treatment for early or mild osteoarthritis caused by developmental dysplasia of the hip. However, the optimal method of surgical reconstruction for older patients remains controversial. The purpose of this retrospective study was to evaluate the clinical and radiographic results of a curved periacetabular osteotomy for the treatment of developmental dysplasia of the hip in patients fifty years of age or older.

METHODS:
We evaluated forty-six consecutive hips in forty-two patients fifty years of age or older (the older group) who had developmental dysplasia of the hip and had undergone a curved periacetabular osteotomy between 1995 and 2006 with a minimum two-year follow-up period. The mean age was 54.6 years. We compared the clinical and radiographic results of this cohort with those of fifty hips in forty-four patients who were less than fifty years old (the younger group) and were managed with the same osteotomy. The mean age was 32.3 years. The patients were matched according to sex and Tönnis grade. Radiographic measurements included the center-edge angle, acetabular roof obliquity, acetabular head index, anterior center-edge angle, and head lateralization index.

RESULTS:
The mean Harris hip score improved from 69.6 points preoperatively to 90.9 points postoperatively in the older group and from 71.1 points preoperatively to 91.8 points postoperatively in the younger group. There were no significant differences in any of the radiographic measurements between the two groups preoperatively or postoperatively. The Tönnis grades improved in two hips and progressed in three hips in the older group and improved in three hips and progressed in three hips in the younger group.

CONCLUSIONS:
Satisfactory results can be obtained clinically and radiographically after curved periacetabular osteotomy in patients fifty years of age or older with Tönnis grade-1 or 2 osteoarthritis of the hip secondary to developmental dysplasia.

LEVEL OF EVIDENCE:
Prognostic Level II. See Instructions to Authors for a complete description of levels of evidence.

ORIGINAL ABSTRACT CITATION:
“Periacetabular Osteotomy in Patients Fifty Years of Age or Older” (2010;92:31-41).
Effects of Age and Body Mass Index on the Results of Transtrochanteric Rotational Osteotomy for Femoral Head Osteonecrosis
Authors: Ha Yong-Chan , Kim Hee Joong , Kim Shin-Yoon , Kim Ki-Choul , Lee Young-Kyun , Koo Kyung-Hoi 
Published: March 2011

BACKGROUND:
Advanced-stage osteonecrosis and a large area of necrotic bone are known risk factors for failure of transtrochanteric rotational osteotomy of the hip in patients with osteonecrosis. The purpose of this study was to determine whether there are other risk factors for failure of this osteotomy.

METHODS:
One hundred and five patients (113 hips) underwent an anterior transtrochanteric rotational osteotomy for the treatment of femoral head osteonecrosis and were followed for a mean of 51.3 months postoperatively. Radiographic failure was defined as secondary collapse or osteoarthritic change. Multivariate analysis was performed to assess factors associated with secondary collapse and osteophyte formation. The Kaplan-Meier product-limit method was used to estimate survival.

RESULTS:
Secondary collapse occurred in twenty-seven hips (24%), and fourteen hips (12%) were converted to a total hip arthroplasty. At the time of the most recent follow-up, the hip scores according to the system of Merle d'Aubigné et al. ranged from 6 to 18 points (mean, 15.8 points). Multivariate analysis showed that the stage of the necrosis (III or greater) (hazard ratio = 3.28; 95% confidence interval = 1.49 to 7.24), age of the patient (forty years or older) (hazard ratio = 1.08; 95% confidence interval = 1.02 to 1.14), body mass index (≥24 kg/m2) (hazard ratio = 1.19; 95% confidence interval = 1.03 to 1.38), and extent of the necrosis (a combined necrotic angle of ≥230°) (hazard ratio = 1.08; 95% confidence interval = 1.04 to 1.11) were associated with secondary collapse. Seven of the eighty-six hips without collapse showed progression to osteoarthritis. The survival rate at 110 months was 63.4% (95% confidence interval = 51.1% to 75.7%) with total hip arthroplasty or radiographic failure as the end point and 56.0% (95% confidence interval = 44.6% to 67.4%) with total hip arthroplasty, radiographic failure, or loss to follow-up as the end point.

CONCLUSIONS:
Our study showed that age, body mass index, and the stage and extent of the osteonecrosis were determining factors for secondary collapse, unsatisfactory clinical results, and conversion to total hip arthroplasty. These factors should be considered when selecting patients for a transtrochanteric rotational osteotomy.

LEVEL OF EVIDENCE:
Prognostic Level II. See Instructions to Authors for a complete description of levels of evidence.

ORIGINAL ABSTRACT CITATION:
“Effects of Age and Body Mass Index on the Results of Transtrochanteric Rotational Osteotomy for Femoral Head Osteonecrosis” (2010;92:314-21).
Impact of Short Daily Hemodialysis on Restless Legs Symptoms and Sleep Disturbances
Authors: Jaber Bertrand L. , Schiller Brigitte , Burkart John M. , Daoui Rachid , Kraus Michael A. , Lee Yoojin , Miller Brent W. , Teitelbaum Isaac , Williams Amy W. , Finkelstein Fredric O. 
Published: March 2011

Summary

Background and objectives
Restless legs syndrome (RLS) and sleep disturbances are common among in-center hemodialysis patients and are associated with increased morbidity/mortality.

Design, setting, participants, & measurements
The FREEDOM study is an ongoing prospective cohort study investigating the benefits of home short daily hemodialysis (SDHD) (6 times/week). In this interim report, we examine the long-term effect of SDHD on the prevalence and severity of RLS, as measured by the International Restless Legs Syndrome (IRLS) Study Group rating scale, and sleep disturbances, as measured by the Medical Outcomes Study sleep survey.

Results
235 participants were included in this report (intention-to-treat cohort), of which 127 completed the 12-month follow-up (per-protocol cohort). Mean age was 52 years, 55% had an arteriovenous fistula, and 40% suffered from RLS. In the per-protocol analysis, among patients with RLS, the mean IRLS score improved significantly at month 12, after adjustment for use of RLS-related medications (18 versus 11). Among patients with moderate-to-severe RLS (IRLS score ≥15), there was an even greater improvement in the IRLS score (23 versus 13). The intention-to-treat analysis yielded similar results. Over 12 months, there was decline in the percentage of patients reporting RLS (35% versus 26%) and those reporting moderate-to-severe RLS (59% versus 43%). There was a similar and sustained 12-month improvement in several scales of the sleep survey, after adjustment for presence of RLS and use of anxiolytics and hypnotics.

Conclusions
Home SDHD is associated with long-term improvement in the prevalence and severity of RLS and sleep disturbances.
Sleep and Activity in Chronic Kidney Disease
Authors: Agarwal Rajiv , Light Robert P. 
Published: March 2011

Summary

Background and objectives
Commonly sleep is disrupted and physical activity is restricted among patients with CKD and those on long-term dialysis. However, few studies have assessed patients longitudinally.

Design, setting, participants, & measurements
We compared the prevalence of sleep disturbances measured both subjectively using a questionnaire and objectively using actimetry among patients with CKD (n = 145), those on hemodialysis (n = 116), and people without kidney disease (n = 19). Activity level during the day was measured using actimetry, and patients were then followed for up to 2 years.

Results
Compared with people without kidney disease, patients with CKD not on dialysis had disruption of sleep that was independent of several risk factors. However, disrupted sleep was correlated with neither estimated GFR in cross-sectional nor longitudinal assessment. Those on hemodialysis had sleep disruption that was of much greater severity than that found among those with CKD not on dialysis. Furthermore, missing or shortening the prescribed duration of dialysis was associated with greater severity of sleep disturbance in cross-sectional but not in longitudinal assessment. Day-time activity declined both in duration and intensity from controls to CKD to hemodialysis.

Conclusions
The loss of kidney function is related to both reduced duration and intensity of day time physical activity. Although patients with CKD have disrupted sleep, this is independent of estimated GFR. However, compared with those with CKD, dialysis patients have more severely disrupted sleep; this is related to missing dialysis. Thus, shortening patients' dialysis may reduce their sleep.
Bilateral lipoma arborescens of the knee: a case report
Authors: Perdikakis Evangelos , Karantanas Apostolos 
Published: March 2011

AbstractLipoma arborescens, a diffuse articular lipomatosis, is a rare disorder characterized by marked villiform synovial proliferation and diffuse replacement of the subsynovial tissue by mature adipocytes. Unilateral joint involvement is the usual presentation while bilateral joint involvement is more uncommon. We reported a case of bilateral lipoma arborescens in a male patient with associated marked patellofemoral osteoarthritis and described the MR imaging findings.
Correlation between phq-9 score and physical activity level, risk factors and non-communicable diseases in patients in family medicine clinic
Authors: Gavric Zivana , Culafic Anna , Markovic Brankica 
Published: March 2011

AbstractThe work of physicians in primary health care is essential in prevention and early detection of health risk factors. To determine the incidence of depression among patients in family medicine clinics, as well as the correlation between depression, risk factors and NCDs, and to determine correlation between depression (PHQ-9 score) and the level of physical activity. The pilot study was conducted from January to March 2010 on 100 patients using the Patient Health Questionnaire (PHQ-9) and the International Physical Activity Questionnaire (IPAQ). The family doctor randomly interviewed and measured patients’ weight, height, blood pressure, fasting blood glucose and cholesterol and noted the presence of earlier diagnosed non-communicable diseases. The data for 92 patients were processed according to PHQ-9 and IPAQ guidelines. Out of 92 patients, 59 (64,1%) had PHQ-9 score ≤ 4 which suggests the absence of depression. The PHQ-9 score median was within normal limits, therefore, treatment was not required and there was no difference in PHQ-9 score median between patients with respect to age and sex. The level of physical activity was moderate in 39,1%, heavy in 35,9% and walking as physical activity in 25,0% of patients. Correlation coefficient between PHQ-9 score and MET score (r=−0,241) was statistically significant (p<0,05), as well as between PHQ -9 score and anxiety (r=0,27; p<0,01). Most studies show a correlation between depression and physical activity. It is essential to promote physical activity in order to prevent anxiety, depression and non-communicable diseases.
Metal ions, Alzheimer's disease and chelation therapy
Authors: Budimir Ana 
Published: March 2011

Metal ions, Alzheimer's disease and chelation therapyIn the last few years, various studies have been providing evidence that metal ions are critically involved in the pathogenesis of major neurological diseases (Alzheimer, Parkinson). Metal ion chelators have been suggested as potential therapies for diseases involving metal ion imbalance. Neurodegeneration is an excellent target for exploiting the metal chelator approach to therapeutics. In contrast to the direct chelation approach in metal ion overload disorders, in neurodegeneration the goal seems to be a better and subtle modulation of metal ion homeostasis, aimed at restoring ionic balance. Thus, moderate chelators able to coordinate deleterious metals without disturbing metal homeostasis are needed. To date, several chelating agents have been investigated for their potential to treat neurodegeneration, and a series of 8-hydroxyquinoline analogues showed the greatest potential for the treatment of neurodegenerative diseases.
Endovascular stent therapy for extracranial and intracranial carotid artery dissection: single-center experience
Authors: Ohta Hajime , Natarajan Sabareesh K. , Hauck Erik F. , Khalessi Alexander A. , Siddiqui Adnan H. , Hopkins L. Nelson , Levy Elad I. 
Published: March 2011

Object
The objective of this study was to evaluate endovascular stent therapy for carotid artery dissections (CADs).

Methods
Retrospective review of data at Millard Fillmore Gates Hospital identified 43 patients with 44 CADs (intracranial and/or extracranial) treated with carotid artery (CA) stent placement between January 2000 and June 2009.

Results
Thirty-two CADs were spontaneous and 12 were traumatic; 35 were symptomatic. Lesion locations included the extracranial internal CA (ICA; 24 cases), extracranial ICA with common CA involvement (4 cases), and extracranial ICA–intracranial ICA (16 cases). Carotid artery occlusion was 100% in 15 cases (34.1%), 99% in 6 cases (13.6%), 70%–98% in 13 cases (29.5%), and < 70% in 10 cases (22.7%). Five patients suffered pseudoaneurysms. Stent deployment was successful in 43 (97.7%) of 44 cases. The mean pretreatment score on the National Institutes of Health Stroke Scale was 6.2 ± 6.2. Recanalization (Thrombolysis in Myocardial Infarction Grade 2 or 3) was accomplished for 42 lesions (95.5%). Four patients demonstrated residual parent vessel stenosis (10%–50% in severity). Procedure-related complications occurred in 7 patients and included middle cerebral artery embolism (1 patient), intracranial hemorrhage (2 patients), worsening of dissection (1 patient), stent malpositioning (1 patient), embolic protection filter overload (1 patient), and filter retrieval device fracture (1 patient). Only 2 of these complications caused permanent deficits: the embolism caused a minor but permanent neurological deficit, and 1 intracranial hemorrhage was fatal. At discharge, 36 patients (83.7%) had modified Rankin Scale scores of 0–2 (favorable outcome). During the follow-up interval (mean 19.2 months, range 4–92 months), no patient suffered a new stroke and 1 patient died secondary to preexisting chronic renal failure. In 20 patients with angiographic follow-up, permanent resolution of the dissection was noted in 90.5%; 2 lesions (9.5%) required retreatment.

Conclusions
Endovascular stent-assisted repair of extra- and intracranial CAD was safe and effective in this experience and can be recommended for selected patients. In particular, patients with symptomatic CADs that are not responsive to medical therapy should be considered for interventional treatment.
Patient satisfaction with surgery for cervical myelopathy due to ossification of the posterior longitudinal ligament
Authors: Fujimori Takahito , Iwasaki Motoki , Okuda Shinya , Nagamoto Yukitaka , Sakaura Hironobu , Oda Takenori , Yoshikawa Hideki 
Published: March 2011

Object
Surgical results in cervical myelopathy caused by ossification of the posterior longitudinal ligament (OPLL) evaluated with a patient-based method have not yet been reported. The purpose of this study was to examine patient satisfaction with surgery for cervical myelopathy due to OPLL and to clarify factors related to satisfaction.

Methods
Clinical data in 103 patients (74 male and 29 female) who underwent surgery for cervical OPLL were retrospectively reviewed. The average age at surgery was 57 years, and the average follow-up period was 9.3 years. Outcomes were assessed using an original satisfaction questionnaire, the conventional Japanese Orthopaedic Association (JOA) scoring system, the JOA Cervical Myelopathy Evaluation Questionnaire, the 36-Item Short Form Health Survey, and the hospital anxiety and depression scale. Spearman rank correlation coefficients for 5-scale patient satisfaction against outcome measures were calculated to test relationships between variables. All variables were compared between the satisfied (responses of very satisfied or satisfied) and dissatisfied (responses of dissatisfied or very dissatisfied) groups. Parameters exhibiting a significant Spearman rank correlation or difference between the groups were entered in a stepwise logistic regression analysis model, with satisfaction as the dependent variable.

Results
Sixty-nine patients were included in the analysis. There was not a significant difference in clinical data between these 69 study patients and the other 34 patients. Fifty-five patients (80%) were satisfied with the results of the surgery, and 58 patients (84%) reported that their condition was improved by the surgery. All patients who reported being very improved were either very satisfied or satisfied with the results of surgery. Quality of life (QOL), physical function (PF), and role physical (RP) were significantly correlated with patient satisfaction. The dissatisfied group had significantly more severe pain; lower maximum conventional JOA scores; lower maximum recovery rates; worse lower-extremity function (LEF); reduced QOL; and lower PF, RP, and vitality scores. Stepwise logistic regression analysis showed that PF, QOL, LEF, and maximum recovery rate based on JOA score were correlated with satisfaction.

Conclusions
Eighty percent of patients were satisfied with the surgical results after treatment of cervical myelopathy due to OPLL. Surgery for cervical OPLL was effective, as evaluated by both doctor- and patient-based methods. Patient satisfaction was related to QOL, PF (especially LEF), and improvement.
Lateral supracerebellar transtentorial approach for petroclival meningiomas: operative technique and outcome
Authors: Watanabe Takao , Katayama Yoichi , Fukushima Takao , Kawamata Tatsuro 
Published: March 2011

Object
The retrosigmoid intradural suprameatal approach with the patient in a semisitting position is an effective alternative to transpetrosal approaches for the treatment of petroclival meningiomas. The authors have made a simple modification to the retrosigmoid intradural suprameatal approach by using the lateral oblique position and preferentially dividing the tentorium with limited drilling of the suprameatal bone, which is termed the “lateral supracerebellar transtentorial approach.”

Methods
Twenty-six patients with petroclival meningiomas surgically treated via the lateral supracerebellar transtentorial approach were analyzed. All tumors had most of their bulk in the posterior fossa with some degree of extension into the middle fossa and/or Meckel cave. The patient is placed in the lateral oblique position, and a standard retrosigmoid craniotomy is performed. The tentorium medial to the trigeminal nerve is incised toward the free edge, which improves exposure to the petroclival region without extensive resection of the suprameatal petrous bone.

Results
Gross-total resection was achieved in 11 patients (42%). Ten patients (38%) underwent subtotal resection, and 5 patients (19%) underwent partial resection. There was no incidence of operative death, and the postoperative permanent morbidity rate was 15%. All patients except one did well postoperatively and were independent at the time of their last follow-up examinations.

Conclusions
The lateral supracerebellar transtentorial approach provides the simplest and safest access to the petroclival region. It offers an advantageous approach to petroclival meningiomas exclusively located in the posterior fossa with minimal extension into the Meckel cave and middle fossa.