bluuebunny/crossref_metadata_2025_split huggingface dataset:
Conjugated Hyperbranched Poly(aryleneethynylene)s: Synthesis, Photophysical Properties, Superquenching by Explosive, Photopatternability, and Tunable High Refractive Indices
Authors: Yuan Wang Zhang , Hu Rongrong , Lam Jacky W. Y. , Xie Ni , Jim Cathy K. W. , Tang Ben Zhong 
Published: February 2012

AbstractTriphenylamine (TPA)‐based conjugated hyperbranched poly(aryleneethynylene)s (PAEs), hb‐P1/2, hb‐P1/3, and hb‐P1/4, were synthesized with high molecular weights and good solubilities through Sonogashira coupling reactions. These PAEs exhibited outstanding thermal stabilities and different emission behaviors. Tetraphenylethene (TPE)‐containing hb‐P1/2 fluoresced faintly in THF, although its light emission was enhanced by aggregate formation in aqueous media or in thin films, thereby exhibiting an aggregation‐induced emission‐enhancement (AIEE) effect. Whereas 1,1,2,3,4,5‐hexaphenylsilole (HPS)‐bearing hb‐P1/3 showed no significant change in emission intensity with increasing water content in aqueous media, hb‐P1/4, which consisted of TPA–fluorenone donor–acceptor groups, presented almost identical absorptions, but both positive and negative solvatochromic emissions in various solvents. A superquenching effect was observed in the picric‐acid‐detection process by using nanosuspensions of hb‐P1/2. All of the polymers possessed good film formability. UV irradiation of the thin films induced simultaneous photobleaching and cross‐linking, thus making them applicable in the fabrication of 2D and 3D patterns. Furthermore, the polymer films also showed high refractive indices, which were tunable upon exposure to UV light.
Oligoether‐Strapped Calix[4]pyrrole: An Ion‐Pair Receptor Displaying Cation‐Dependent Chloride Anion Transport
Authors: Park In‐Won , Yoo Jaeduk , Kim Bohyang , Adhikari Suman , Kim Sung Kuk , Yeon Yerim , Haynes Cally J. E. , Sutton Jennifer L. , Tong Christine C. , Lynch Vincent M. , Sessler Jonathan L. , Gale Philip A. , Lee Chang‐Hee 
Published: February 2012

AbstractA ditopic ion‐pair receptor (1), which has tunable cation‐ and anion‐binding sites, has been synthesized and characterized. Spectroscopic analyses provide support for the conclusion that receptor 1 binds fluoride and chloride anions strongly and forms stable 1:1 complexes ([1⋅F]− and [1⋅Cl]−) with appropriately chosen salts of these anions in acetonitrile. When the anion complexes of 1 were treated with alkali metal ions (Li+, Na+, K+, Cs+, as their perchlorate salts), ion‐dependent interactions were observed that were found to depend on both the choice of added cation and the initially complexed anion. In the case of [1⋅F]−, no appreciable interaction with the K+ ion was seen. On the other hand, when this complex was treated with Li+ or Na+ ions, decomplexation of the bound fluoride anion was observed. In contrast to what was seen with Li+, Na+, K+, treating [1⋅F]− with Cs+ ions gave rise to a stable, host‐separated ion‐pair complex, [F⋅1⋅Cs], which contains the Cs+ ion bound in the cup‐like portion of the calix[4]pyrrole. Different complexation behavior was seen in the case of the chloride complex, [1⋅Cl]−. Here, no appreciable interaction was observed with Na+ or K+. In contrast, treating with Li+ produces a tight ion‐pair complex, [1⋅Li⋅Cl], in which the cation is bound to the crown moiety. In analogy to what was seen for [1⋅F]−, treatment of [1⋅Cl]− with Cs+ ions gives rise to a host‐separated ion‐pair complex, [Cl⋅1⋅Cs], in which the cation is bound to the cup of the calix[4]pyrrole. As inferred from liposomal model membrane transport studies, system 1 can act as an effective carrier for several chloride anion salts of Group 1 cations, operating through both symport (chloride+cation co‐transport) and antiport (nitrate‐for‐chloride exchange) mechanisms. This transport behavior stands in contrast to what is seen for simple octamethylcalix[4]pyrrole, which acts as an effective carrier for cesium chloride but does not operates through a nitrate‐for‐chloride anion exchange mechanism.
Cooperative Catalytic Reactions Using Distinct Transition‐Metal Catalysts: Ruthenium‐ and Copper‐Catalyzed Enantioselective Propargylic Alkylation
Authors: Ikeda Masahiro , Miyake Yoshihiro , Nishibayashi Yoshiaki 
Published: February 2012

AbstractThe enantioselective propargylic alkylation of propargylic alcohols with β‐ketoesters in the presence of a thiolate‐bridged diruthenium complex and a copper complex as co‐catalyst affords the corresponding propargylic alkylated products in excellent yields as a mixture of two diastereoisomers with high enantioselectivity (up to 95 % enantiomeric excess (ee)). The findings reported herein not only open up a new type of enantioselective propargylic substitution reaction, but also a new aspect of cooperative catalytic reactions using distinct transition metals to realize a useful transformation that cannot be achieved by a single catalyst.
An overview of solid–liquid separation of residues from coal liquefaction processes
Authors: Khare S. , Dell'Amico M. 
Published: February 2012

AbstractDirect coal liquefaction process typically produces mixed oils (60%) and gases (15%). The remainder is a high‐boiling viscous residue that contains oils, asphaltenes, unreacted coal, mineral matter and potentially valuable liquefaction catalyst. Effective separation of the components of the residue stream is important to the economic and environmental performance of the process. Solid–liquid separation technologies, such as filtration, hydrocyclones, centrifugation, critical solvent deashing and distillation have been reviewed in relation to their use in coal liquefaction processes. Individual operations used have not been completely satisfactory, and a better overall result is obtained when they are used in combination. © 2012 Canadian Society for Chemical Engineering
Arylpiperazine Dopamineric Ligands Protect Neuroblastoma Cells from Nitric Oxide (NO)‐Induced Mitochondrial Damage and Apoptosis
Authors: Tovilovic Gordana , Zogovic Nevena , Harhaji‐Trajkovic Ljubica , Misirkic‐Marjanovic Maja , Janjetovic Kristina , Vucicevic Ljubica , Kostic‐Rajacic Sladjana , Schrattenholz Andre , Isakovic Aleksandra , Soskic Vukic , Trajkovic Vladimir 
Published: February 2012

AbstractThe protective ability of novel arylpiperazine‐based dopaminergic ligands against nitric oxide (NO)‐mediated neurotoxicity is investigated. The most potent neuroprotective arylpiperazine identified during the study was N‐{4‐[2‐(4‐phenyl‐piperazin‐1‐yl)ethyl]‐phenyl}picolinamide, which protected SH‐SY5Y human neuron‐like cells from the proapoptotic effect of NO donor sodium nitroprusside (SNP) by decreasing oxidative stress, mitochondrial membrane depolarization, caspase activation and subsequent phosphatydilserine externalization/DNA fragmentation. The protective effect was associated with the inhibition of proapoptotic (JNK, ERK, AMPK) and activation of antiapoptotic (Akt) signaling pathways, in the absence of interference with intracellular NO accumulation. The neuroprotective action of arylpiperazines was shown to be independent of dopamine receptor binding, as it was not affected by the high‐affinity D1/D2 receptor blocker butaclamol. These results reported support the further study of arylpiperazines as potential neuroprotective agents.
A survey and comparison of multichannel protocols for performance anomaly mitigation in IEEE 802.11wireless networks
Authors: Kim Sok‐Hyong , Kim Dong‐Wook , Suh Young‐Joo 
Published: February 2012

SUMMARYProviding multichannel functionality can improve the performance of wireless networks. Although off‐the‐shelf IEEE 802.11 physical layer and medium access control specifications support multiple channels and multiple data rates, one of the major challenges is how to efficiently utilize available channels and data rates to improve network performance. In multirate networks, low‐rate links severely degrade the capacity of high‐rate links, which is known as performance anomaly. To overcome the performance anomaly problem, different data rate links can get equal air‐time by exploiting time diversity and frequency diversity, or they can be separated over nonoverlapping channels. In this paper, we study existing multichannel protocols proposed to mitigate the performance anomaly problem by classifying them into single‐radio protocols, multiradio single‐hop protocols, and multiradio multihop protocols. To investigate the effectiveness of multichannel solutions for performance anomaly, we compare these protocols with well‐known multichannel protocols that do not consider performance anomaly. In addition, this paper gives insightful research issues to design multichannel protocols that mitigate performance anomaly in IEEE 802.11 wireless networks. Copyright © 2012 John Wiley & Sons, Ltd.
Mediastinal seminoma: A case report with special emphasis on SALL4 as a new immunocytochemical marker
Authors: Iwamoto Nozomi , Ishida Mitsuaki , Yoshida Keiko , Kagotani Akiko , Iwai Muneo , Okabe Hidetoshi 
Published: February 2012

Cytological diagnosis is a valuable method for detection of mediastinal tumors, and recent reports have shown the usefulness of fine‐needle aspiration cytology for diagnosis of mediastinal tumors, including germ cell tumors. We report a case of mediastinal seminoma diagnosed intraoperatively by cytological examination of cystic fluid containing tumor cells.An anterior mediastinal tumor with cystic component was incidentally found in a 28‐year‐old Japanese male. Cytological examination of the cystic fluid at the time of tumor resection showed single and loose aggregates of large round to polygonal cells with large round nuclei, vesicular chromatin and nucleoli, and mild to moderate amounts of PAS‐positive cytoplasm admixed with mature lymphocytes. A diagnosis of seminoma was made intraoperatively. On subsequent immunostaining, the tumor cells showed nuclear positivity for SALL4, a recently recognized germ cell marker that, in the appropriate setting, can be helpful to distinguish germ cell tumors from other mediastinal neoplasms, such as malignant lymphoma, thymoma, and thymic carcinoma. Diagn. Cytopathol. 2013;41:821–824. © 2012 Wiley Periodicals, Inc.
Pharmacological and Toxicological Profile of Extract from Heliopsislongipes and Affinin
Authors: Déciga‐Campos Myrna , Arriaga‐Alba Myriam , Ventura‐Martínez Rosa , Aguilar‐Guadarrama Berenice , Rios María Yolanda 
Published: February 2012

Abstract

Strategy, Management and Health Policy

Enabling Technology, Genomics, Proteomics
Preclinical Research
Preclinical Development Toxicology, Formulation Drug Delivery, Pharmacokinetics
Clinical Development Phases I‐III Regulatory, Quality, Manufacturing
Postmarketing Phase IV

Heliopsis longipes is a popular medicinal plant in Mexico. One of the main constituents that can be extracted from H. longipes is affinin (N‐isobutylamide). However, available information regarding this compound is scarce, and there is only a single report related to the effect of affinin on the central nervous system. Affinin extracted from H. longipes was evaluated for its psychopharmacological activity in several models and for its safety. H. longipes extract and affinin demonstrated antinociceptive effect, modified anxiety behavior and prolonged the time of sodium pentobarbital‐induced hypnosis. Affinin elicited these activities at high doses. Both the extract and affinin decreased the time of clonic and tonic PTZ‐induced seizures. In the Ames test, neither the extract nor affinin induced mutations in the Salmonella typhimurium strains TA98 and TA100 or TA102 with or without the S9 microsomal fraction. Lethal dose 50 values in mice suggest that the H. longipes extract may contain sedative principles with potential anxiolytic activity; however, it may also increase convulsive activity.
Adenosine A2A receptors modulate glutamate uptake in cultured astrocytes and gliosomes
Authors: Matos Marco , Augusto Elisabete , Santos‐Rodrigues Alexandre Dos , Schwarzschild Michael A. , Chen Jiang‐Fan , Cunha Rodrigo A. , Agostinho Paula 
Published: February 2012

AbstractGlutamate is the primary excitatory neurotransmitter in the central nervous system, where its toxic build‐up leads to synaptic dysfunction and excitotoxic cell death that underlies many neurodegenerative diseases. Therefore, efforts have been made to understand the regulation of glutamate transporters, which are responsible for the clearance of extracellular glutamate. We now report that adenosine A2A receptors (A2
AR) control the uptake of D‐aspartate in primary cultured astrocytes as well as in an ex vivo preparation enriched in glial plasmalemmal vesicles (gliosomes) from adult rats, whereas A1R and A3R were devoid of effects. Thus, the acute exposure to the A2
AR agonist, CGS 21680, inhibited glutamate uptake, an effect prevented by the A2
AR antagonist, SCH 58261, and abbrogated in cultured astrocytes from A2
AR knockout mice. Furthermore, the prolonged activation of A2
AR lead to a cAMP/protein kinase A‐dependent reduction of GLT‐I and GLAST mRNA and protein levels, which leads to a sustained decrease of glutamate uptake. This dual mechanism of inhibition of glutamate transporters by astrocytic A2
AR provides a novel candidate mechanism to understand the ability of A2
AR to control synaptic plasticity and neurodegeneration, two conditions tightly associated with the control of extracellular glutamate levels by glutamate transporters. © Wiley Periodicals, Inc.
ATP‐P2X7 receptor signaling controls basal and TNFα‐stimulated glial cell proliferation
Authors: Zou Jian , Vetreno Ryan P. , Crews Fulton T. 
Published: February 2012

AbstractActivation and proliferation of glial cells and their progenitors is a key process of neuroinflammation associated with many neurodegenerative disorders. Under neuropathological conditions where glial cell activation and proliferation is evident, controlling the population of glia might be of therapeutic importance. The proliferative action of the cytokine tumor necrosis factor alpha (TNFα) on microglia has been reported, but the molecular mechanism of TNFα regulation of glial cell proliferation is largely unknown. Using a model of organotypic hippocampal–entorhinal cortex (HEC) slice culture, we investigated the role of ATP‐P2X7 receptor signaling in glial proliferation by TNFα. Populations of proliferating cells in HEC culture were labeled with 5‐bromo‐2′‐deoxyuridine (BrdU). Treatment with TNFα induced strong expression of P2X7 receptor mRNA and immunoreactivity in BrdU+ cells while markedly increasing proliferation of BrdU+ cells. In addition, TNFα increased aquaporin 4 (AQP4) expression, an ion channel involved in glial proliferation. The proliferative action of TNFα was attenuated by blocking the P2X7 receptors with the specific antagonists oxATP, BBG, and KN62, or by lowering extracellular ATP with ATP hydrolysis apyrase. Basal proliferation of BrdU+ cells was also sensitive to blockade of ATP‐P2X7 signaling. Furthermore, TNFα activation of P2X7 receptors appear to regulate AQP4 expression through protein kinase C cascade and down regulation of AQP4 expression can reduce TNFα‐stimulated BrdU+ cell proliferation. Taken together, these novel findings demonstrate the importance of ATP‐P2X7 signaling in controlling proliferation of glial progenitors under the pathological conditions associated with increased TNFα. © 2012 Wiley Periodicals, Inc.
Overexpression of hTERT extends replicative capacity of human nucleus pulposus cells, and protects against serum starvation‐induced apoptosis and cell cycle arrest
Authors: Liang Weiguo , Ye Dongping , Dai Libing , Shen Yan , Xu Jiake 
Published: February 2012

AbstractThe nucleus pulposus (NP) cells are chondrocyte‐like cells that are required for the resistance of compressive loads through the synthesis of collagen fibrils and proteoglycan aggrecans, and the generation of a hydrostatic swelling pressure, and thus play an important role in the intervertebral disc. Here, we report the production and characterization of an immortalized human NP cell line from normal NP cells using stable transfection of recombinant human telomerase reverse transcriptase (hTERT) gene. The hTERT‐transfected NP cells exhibited morphological characteristics typical of native cells. When compared with the first generation of normal NP cells, the hTERT‐transfected NP cells grew faster and had an increased level of IGF‐1 and TGF‐β gene expression. They were successfully passaged over 20 generations without significant change in the levels of type II collagen and proteoglycan aggrecan expression. In addition, they showed resistance to serum starvation‐induced apoptosis, G1 cell cycle arrest, and gene expression of p53, CCNE1, Fas, and Caspase 3. Moreover, histology revealed that no tumorigenicity of NP cells over expressing hTERT was observed after they were implanted in nude mice. Taken together, an immortalized human NP cell line was established, which has an extended lifespan, retains phenotypic features similar to primary parent NP cells, and should provide a suitable model for studying the biology of NP cells. J. Cell. Biochem. 113: 2112–2121, 2012. © 2012 Wiley Periodicals, Inc.
Clinical significance of circulating interleukin‐23 as a prognostic factor in breast cancer patients
Authors: Gangemi Sebastiano , Minciullo Paola , Adamo Barbara , Franchina Tindara , Ricciardi Giuseppina R.R. , Ferraro Maria , Briguglio Roberta , Toscano Giuseppe , Saitta Salvatore , Adamo Vincenzo 
Published: February 2012

AbstractLittle is known about specific IL‐23 alterations associated with breast cancer and the data available are still controversial. Therefore, the evaluation of changes in serum IL‐23 levels may add further information on the role of this cytokine in breast cancer patients. The aim of this study was to evaluate prospectively the prognostic importance of circulating IL‐23 in patients with untreated breast cancer, respect to healthy controls, and the association with clinico‐pathological variables. The study involved 50 women diagnosed with stages I–IV breast cancer and 38 healthy controls. Of the 50 breast cancer patients, 37 women were recruited prior to their initial adjuvant chemotherapy and 13 prior to receive first line chemotherapy for metastatic disease. Adjuvant chemotherapy patients were at least in their 4th week post‐surgery. IL‐23 serum concentrations were measured by a quantitative enzyme immunoassay technique. We found a statistically significant higher systemic cytokine value in women with cancer in comparison with the control group (14.52 ± 11.39 pg/ml vs. 6.35 ± 4.63 pg/ml, P < 0.0001). Patients with shorter overall survival presented higher IL‐23 values, suggesting a negative prognostic correlation. There was no significant differences in IL‐23 levels among patients according to the biomolecular characteristics, the different subtypes and the presence of metastatic disease. This work investigated, for the first time, the role of IL‐23 in breast cancer patients showing a significant increase respect the control group. However, further validations are needed in larger studies to better investigate the implications of IL‐23 increase in these patients. J. Cell. Biochem. 113: 2122–2125, 2012. © 2012 Wiley Periodicals, Inc.
Decursin inhibits vasculogenesis in early tumor progression by suppression of endothelial progenitor cell differentiation and function
Authors: Jung Seok Yun , Choi Jin Hwa , Kwon Sang‐Mo , Masuda Haruchika , Asahara Takayuki , Lee You‐Mie 
Published: February 2012

AbstractEndothelial progenitor cells (EPCs) contribute to the tumor vasculature during tumor progression. Decursin isolated from the herb Angelica gigas is known to possess potent anti‐inflammatory activities. Recently, we reported that decursin is a novel candidate for an angiogenesis inhibitor [Jung et al., 2009]. In this study, we investigated whether decursin regulates EPC differentiation and function to inhibit tumor vasculogenesis. We isolated AC133+ cells from human cord blood and decursin significantly decreased the number of EPC colony forming units of human cord blood‐derived AC133+ cells that produce functional EPC progenies. Decursin dose‐dependently decreased the cell number of EPC committing cells as demonstrated by EPC expansion studies. Decursin inhibited EPC differentiation from progenitor cells into spindle‐shaped EPC colonies. Additionally, decursin inhibited proliferation and migration of early EPCs isolated from mouse bone marrow. Furthermore, decursin suppressed expression of angiopoietin‐2, angiopoietin receptor Tie‐2, Flk‐1 (vascular endothelial growth factor receptor‐2), and endothelial nitric oxide synthase in mouse BM derived EPCs in a dose‐dependent manner. Decursin suppressed tube formation ability of EPCs in collaboration with HUVEC. Decursin (4 mg/kg) inhibited tumor‐induced mobilization of circulating EPCs (CD34 + /VEGFR‐2+ cells) from bone marrow and early incorporation of Dil‐Ac‐LDL‐labeled or green fluorescent protein (GFP)+ EPCs into neovessels of xenograft Lewis lung carcinoma tumors in wild‐type‐ or bone‐marrow‐transplanted mice. Accordingly, decursin attenuated EPC‐derived endothelial cells in neovessels of Lewis lung carcinoma tumor masses grown in mice. Together, decursin likely affects EPC differentiation and function, thereby inhibiting tumor vasculogenesis in early tumorigenesis. J. Cell. Biochem. 113: 1478–1487, 2012. © 2012 Wiley Periodicals, Inc.
Phosphorylation target site specificity for AGC kinases DMPK E and lats2
Authors: Gerrits Lieke , Venselaar Hanka , Wieringa Bé , Wansink Derick G. , Hendriks Wiljan J.A.J. 
Published: February 2012

AbstractSerine/threonine kinases of the AGC group are important regulators of cell growth and motility. To examine the candidate substrate profile for two members of this group, DMPK E and Lats2, we performed in vitro kinase assays on peptide arrays. Substrate peptides for both kinases exhibited a predominance of basic residues surrounding the phosphorylation target site. 3D homology modeling of the kinase domains of DMPK E and Lats2 indicated that presence of two negative pockets in the peptide binding groove provides an explanation for the substrate preference. These findings will aid future research toward signaling functions of Lats2 and DMPK E within cells. J. Cell. Biochem. 113: 2126–2135, 2012. © 2012 Wiley Periodicals, Inc.
Fourier transform general formula for systematic potentials
Authors: Ishida Kazuhiro 
Published: February 2012

AbstractFor calculating molecular integrals of systematic potentials, a three‐dimensional (3D) Fourier transform general formula can be derived, by the use of the Abel summation method. The present general formula contains all 3D Fourier transform formulas which are well known as Bethe–Salpeter formulas (Bethe and Salpeter, Handbuch der Physik, Bd. XXXV, 1957) as special cases. It is shown that, in several of the Bethe–Salpeter formulas, the integral does not converge in the meaning of the Riemann integral but converges in the meaning of a hyper function as the Schwartz distribution. For showing an effectiveness of the present general formula, the convergence condition of molecular integrals is derived generally for all of the present potentials. It is found that molecular integrals can be converged in the meaning of the Riemann integral for the present potentials, except for those for extra super singular potentials. It is also found that the convergence condition of molecular integrals over the Slater‐type orbitals is exactly the same as that of the corresponding integrals over the Gaussian‐type orbitals for the present systematic potentials. For showing more effectiveness, the molecular integral over the gauge‐including atomic orbitals is derived for the magnetic dipole‐same‐dipole interaction. © 2012 Wiley Periodicals, Inc.