bluuebunny/crossref_metadata_2025_split huggingface dataset:
Enhancing multi‐site autism research through the development of a collaborative data platform
Authors: Anderson Jeffrey T. , Roth Jeffrey D. , Rosenau Kashia A. , Dwyer Patrick S. , Kuo Alice A. , Martinez‐Agosto Julian A. 
Published: May 2024

AbstractData repositories, particularly those storing data on vulnerable populations, increasingly need to carefully consider not only what data is being collected, but how it will be used. As such, the Autism Intervention Research Network on Physical Health (AIR‐P) has created the Infrastructure for Collaborative Research (ICR) to establish standards on data collection practices in Autism repositories. The ICR will strive to encourage inter‐site collaboration, amplify autistic voices, and widen accessibility to data. The ICR is staged as a three‐tiered framework consisting of (1) a request for proposals system, (2) a REDCap‐based data repository, and (3) public data dashboards to display aggregate de‐identified data. Coupled with a review process including autistic and non‐autistic researchers, this framework aims to propel the implementation of equitable autism research, enhance standardization within and between studies, and boost transparency and dissemination of findings. In addition, the inclusion of a contact registry that study participants can opt into creates the base for a robust participant pool. As such, researchers can leverage the platform to identify, reach, and distribute electronic materials to a greater proportion of potential participants who likely fall within their eligibility criteria. By incorporating practices that promote effective communication between researchers and participants, the ICR can facilitate research that is both considerate of and a benefit to autistic people.
A systematic review of procedures for establishing conditioned reinforcers
Authors: Argueta Tracy , Reichow Brian , Talhelm Paige , DeLeon Iser G. 
Published: May 2024

AbstractEstablishing conditioned reinforcers is often critical to treatment for individuals diagnosed with autism spectrum disorder or intellectual and developmental disabilities (IDDs). Although researchers have evaluated several procedures, methods and results vary across studies, making it difficult to draw conclusions about these procedures' general and relative effectiveness. The purpose of this systematic review was to assess the overall and relative effectiveness of stimulus‐stimulus (S‐S) pairing, response‐stimulus (R‐S) pairing, and operant discrimination training (ODT) for establishing conditioned reinforcers for children on the autism spectrum or who have an IDD. Thirty‐one studies, including 12 theses and dissertations, met inclusion criteria. Eight studies evaluated S‐S pairing, 20 evaluated R‐S pairing, and nine evaluated ODT. Combined, S‐S pairing, R‐S pairing, and ODT were effective at establishing conditioned reinforcers in only half of all attempts. However, analysis indicated that R‐S pairing is the most effective procedure, followed by S‐S pairing and ODT, in that order.
Status and future developments for downstream processing of biological products
Authors: Jungbauer Alois , Ferreira Gisela , Butler Michelle , D'Costa Susan , Brower Kevin , Rayat Andrea , Willson Richard 
Published: May 2024

AbstractGovernments and biopharmaceutical organizations aggressively leveraged expeditious communication capabilities, decision models, and global strategies to make a COVID‐19 vaccine happen within a period of 12 months. This was an unusual effort and cannot be transferred to normal times. However, this focus on a single vaccine has also led to other treatments and drug developments being sidelined. Society expects the pharmaceutical industry to provide an uninterrupted supply of medicines. However, it is often overlooked how complex the manufacture of these compounds is and what logistics are required, not to mention the time needed to develop new drugs. The overarching theme, therefore, is patient access and how we can help ensure access and extend it to low‐ and middle‐income countries. Despite unceasing efforts to make medications available to all patient populations, this must never be done at the expense of patient safety. A major fraction of the costs in biopharmaceutical manufacturing are for drug discovery, process development, and clinical studies. Infrastructure costs are very difficult to quantify because they often depend on whether a greenfield facility or an existing, depreciated facility is used or adapted for a new product. To accelerate process development concepts of platform process and prior knowledge are increasingly leveraged. While more traditional protein therapeutics continue to dominate the field, we are also experiencing the exciting emergence and evolution of other therapeutic formats (bispecifics, tetravalent mAbs, antibody‐drug conjugates, enzymes, peptides, etc.) that offer unique treatment options for patients. Protein modalities are still dominant, but new modalities are being developed that can be learned from including advanced therapeutics‐like cell and gene therapies. The industry must develop a model‐based strategy for process development and technologies such as continuous integrated biomanufacturing must be adopted. The overall conclusion is that the pandemic pace was unsustainable, focused on vaccine delivery at the expense of other modalities/disease targets, and had implications for professional and personal life (work‐life balance). Routinely reducing development time from 10 years to 1 year is nearly impossible to achieve. Environmental aspects of sustainable downstream processing are also described.
Assessment of Moroccan Cannabis Sativa Seed Oil: Chemical Analysis and Evaluation of Antioxidant, Toxicological, and Antinociceptive Effects
Authors: Raoui Karima , Kabdy Hamid , Ettitaou Amina , Aitbaba Abdelfatah , Baslam Abdelmounaim , Benrazzouk Karima , Ait Laaradia Mehdi , Laaradraoui Jawad , Oufquir Sara , Elyazouli Loubna , Aboufatima Rachida , Garzoli Stefania , Chait Abderrahman 
Published: May 2024

AbstractAssessment of Moroccan Cannabis sativa Seed Oil: Chemical Analysis and Evaluation of Antioxidant, Toxicological, and Antinociceptive Effects. by K. Raoui et al., Cadi Ayyad University, Marrakech, Morocco. Cannabis sativa L., locally known as “El kif”, belongs to the Cannabaceae family. This study aims to conduct a chemical analysis of Cannabis sativa seed oil (CSSO) and assess its acute toxicity, antioxidant properties, and analgesic effects. The chemical analysis was performed using gas chromatography and mass spectrometry (GC/MS) to identify fatty acids (FAs) contents. Antioxidant activity was evaluated in vitro using the (2,2‐diphenyl‐1‐picrylhydrazyl) DPPH radical scavenging method and the (ferric reducing antioxidant power) FRAP method. Concurrently, acute toxicity, along with antinociceptive activity, was studied through three distinct animal models: writhing test, formalin test, and hot plate test. The results revealed that linoleic acid, oleic acid, α‐linolenic acid, and palmitic acid were the main components of CSSO. The LD50 of CSSO was greater than 5 g/kg, indicating low toxicity. Additionally, CSSO exhibited a significant content of flavonoids and total polyphenols, along with notable antioxidant activity with important values. The results indicated a significant increase in thermal stimulus latency, a reduction in the number of writhes induced by acetic acid, and a decrease in licking time in both phases of the formalin test. In conclusion, this study suggests promising results for CSSO, emphasizing its potential as a therapeutic agent.
Benign adrenal cyst: A rare type of adrenal incidentaloma
Authors: Yamamoto Koichiro , Oguni Kohei , Otsuka Fumio 
Published: May 2024

Key Clinical MessageWe present a patient with hypertension who developed a rare type of incidentaloma, a benign adrenal cyst. Benign adrenal cysts are typically large; however, most are nonfunctioning and asymptomatic, and they can be managed conservatively.
COVID‐19 presenting as severe acute hepatitis in a pediatric patient with thalassemia minor: A case report
Authors: Jamalvi Syed Abdan , Rauf Sameer Abdul , Sherali Atika , Ali Syed Khizar , Shah Hussain Haider , Jamalvi Filza , Yogeeta Fnu , Dave Tirth 
Published: May 2024

Key Clinical MessageThis case emphasizes the significance of COVID‐19 in pediatric patients presenting with unusual hepatic manifestations, urging clinicians to broaden their diagnostic lens. The unexpected elevation of SARS‐CoV‐2 antibodies and the effective use of N‐acetyl cysteine highlight the importance of adaptability in treatment strategies.AbstractThis case report presents a unique manifestation of severe hepatic involvement in a 4‐year‐old girl with thalassemia minor and COVID‐19. Despite the absence of prominent respiratory symptoms, the patient exhibited jaundice, elevated liver enzymes, and coagulopathy. Initial suspicion of viral hepatitis was replaced by the discovery of significantly elevated SARS‐CoV‐2 antibodies. A multidisciplinary approach, including gastroenterology consultation and an extensive workup, was pivotal in ruling out alternative etiologies. Unconventional use of N‐acetyl cysteine contributed to clinical improvement, highlighting the need for adaptable treatment strategies. This case underscores the importance of heightened awareness in recognizing atypical presentations of COVID‐19 in pediatric patients, especially those with underlying health conditions. Further exploration into nuanced manifestations and treatment approaches is warranted for comprehensive clinical management.
Meckel's diverticulum: A rare and missed cause of adult gastrointestinal bleed
Authors: Ramakrishnan Rahul , Kuang Kevin , Rajput Vijay , Mohan Sachin 
Published: May 2024

Key Clinical MessageOur report details a rare case of gastrointestinal bleeding in an adult male from Meckel's diverticulum. Diagnostic tests were negative except for technetium‐99m pertechnetate scintigraphy with SPECT/CT, highlighting importance of diverse modalities.
Sphincter of oddi dysfunction induced by ketamine: A case report
Authors: Sharma Nava Raj , Basnet Arjun , Lamichhane Saral , Tiwari Kripa , Varghese Jeffy , Gautam Sudarshan , Pokhrel Madalasa 
Published: May 2024

Key Clinical MessageChronic ketamine use can lead to sphincter of oddi dysfunction (SOD), causing various hepatobiliary complications. Recognizing substance abuse history is vital for early detection. Timely intervention can prevent irreversible liver and pancreas damage.AbstractKetamine is commonly abused as a recreational drug worldwide due to its ability to induce euphoria‐like effects. Ketamine abuse is associated with many hepatobiliary side effects ranging from cholestasis to biliary sepsis and death. Here we present a case of a young 29‐year female with upper abdominal pain due to SOD resulting from chronic use of ketamine. SOD can result in obstruction or dysfunction of the bile and pancreatic ducts. Ketamine induces SOD by activation of the muscarinic receptors in the sphincter of oddi. Detail history of substance abuse is crucial for early identification of ketamine‐induced SOD. Early identification and treatment of this rare condition can prevent permanent injury to the liver and pancreas.
The Integral Role of Conjugate Acids in Brønsted Base‐Catalyzed Regiodivergent Synthesis
Authors: Chen Yi‐Ru , Marri Gangababu , Lin Wenwei 
Published: May 2024

AbstractCatalyst‐controlled diversity‐oriented synthesis (CatDOS) is an important research area for expanding molecular complexities and achieving high atomic economics. Many regiodivergent syntheses have been achieved through metal catalysis, covalent organocatalysis, and non‐covalent organocatalysis by controlling the molecular recognition function of the catalysts. However, the development of regiodivergent CatDOS through Brønsted base organocatalysis was relatively less developed than others so far. Numerous studies about Brønsted base organocatalysis have demonstrated the powerful molecular recognition abilities of their cationic conjugate acids mainly in controlling the stereoselectivity instead of the regioselectivity. This concept review aims to conceptualize a new perspective to consider the potential role of the cationic conjugate acid of Brønsted bases for regiodivergent CatDOS. Recent representative examples are selected to demonstrate the potential of cationic conjugate acids in site‐selectivity control in single bond and multiple bonds formation reactions. The summarized results show that even the conjugate acid of common tertiary amines, protic ammonium ions, could affect the regioselectivity in the early‐ or late‐stage step during multiple bonds formation after initial deprotonation. The results also suggested that the properties and ion‐pairing interactions of conjugate acid could be more important than the basicity of the base in controlling regioselectivity. Perspectives and hypotheses for explaining the mechanism of regioselectivity are also included in this review.
Surface Engineering of Noble Metal Nanocrystals for Selective Hydrogenation
Authors: Lai Xiaofei , Liang Xijie , Wang Shuai , Xu Yong 
Published: May 2024

AbstractThe selective hydrogenation has attracted increasing attention to chemists for the production of value‐added products in chemical industry. Over the past several decades, substantial effort has been devoted to the design of catalyst for the selective hydrogenation of light alkynes and α, β‐unsaturated aldehydes, two classic cases for selective hydrogenation in chemical industry. Despite the great progress, it remains great challenges to achieve the selective hydrogenation because the desired products are generally thermodynamically unfavored. Here, we summarize the recent advances on selective hydrogenation using noble metal nanocrystals, with an emphasis on the surface engineering of noble metal nanocrystals for the selective hydrogenation of light alkynes and α, β‐unsaturated aldehydes. We will highlight the strategies for surface engineering, the advanced techniques for characterizations, as well as mechanism studies. We hope this review will promote chemists to develop efficient and robust catalysts for selective hydrogenation.
A pragmatic randomized trial of mailed fecal immunochemical testing to increase colorectal cancer screening among low‐income and minoritized populations
Authors: Martínez María Elena , Roesch Scott , Largaespada Valesca , Castañeda Sheila F. , Nodora Jesse N. , Rabin Borsika A. , Covin Jennifer , Ortwine Kristine , Preciado‐Hidalgo Yesenia , Howard Nicole , Schultz James , Stamm Nannette , Ramirez Daniel , Halpern Michael T. , Gupta Samir 
Published: May 2024

AbstractBackgroundColorectal cancer (CRC) screening is underused, particularly among low‐income and minoritized populations, for whom the coronavirus disease 2019 (COVID‐19) pandemic has challenged progress in achieving equity.MethodsA hub‐and‐spoke model was used. The hub was a nonacademic organization and the spokes were three community health center (CHC) systems overseeing numerous clinic sites. Via a cluster‐randomized trial design, nine clinic sites were randomized to intervention and 16 clinic sites were randomized to usual care. Patient‐level interventions included invitation letters, mailed fecal immunochemical tests (FITs), and call/text‐based reminders. Year 1 intervention impact, which took place during the COVID‐19 pandemic, was assessed as the proportion completing screening among individuals not up to date at baseline, which compared intervention and nonintervention clinics accounting for intraclinic cluster variation; confidence intervals (CIs) around differences not including 0 were interpreted as statistically significant.ResultsAmong 26,736 patients who met eligibility criteria, approximately 58% were female, 55% were Hispanic individuals, and 44% were Spanish speaking. The proportion completing screening was 11.5 percentage points (ppts) (95% CI, 6.1–16.9 ppts) higher in intervention versus usual care clinics. Variation in differences between intervention and usual care clinics was observed by sex (12.6 ppts [95% CI, 7.2–18.0 ppts] for females; 8.8 ppts [95% CI, 4.7–13.9 ppts] for males) and by racial and ethnic group (13.8 ppts [95% CI, 7.0–20.6 ppts] for Hispanic individuals; 13.0 ppts [95% CI, 3.6–22.4 ppts] for Asian individuals; 11.3 ppts [95% CI, 5.8–16.8 ppts] for non‐Hispanic White individuals; 6.1 ppts [95% CI, 0.8–10.4 ppts] for Black individuals).ConclusionsA regional mailed FIT intervention was effective for increasing CRC screening rates across CHC systems serving diverse, low‐income populations.
Novel Solid‐State Fluorophores, a Series of Cyanostilbene‐Based Amorphous Molecular Materials
Authors: Fukushima Hiroya , Miyagishi Kou , Mori Kensuke , Sagara Yoshimitsu , Kokado Kenta , Tamaoki Nobuyuki , Nakamura Takayoshi , Nakano Hideyuki 
Published: May 2024

AbstractWe have designed and synthesized a novel series of cyanostilbene‐based amorphous molecular materials with different methylene chain lengths, BMAC‐n (n=3,4,5,6), and investigated their emitting properties in solution and various solid states. All BMAC‐n molecules showed solvatochromic fluorescence in solutions. Emission spectra of BMAC‐n molecules in the same solution were identical to one another irrespective of the methylene chain length while the spectra in crystalline states depended on their methylene chain length. As in solutions, emission spectra of their spin‐coated amorphous films were identical to each other irrespective of the methylene chain length. Emission spectra of rubbed amorphous films prepared by grinding their crystals were identical to those for spin‐coated amorphous films; however, comparative studies between spin‐coated and rubbed amorphous films indicated that fluorescence quantum yields and photochemical reactivity depend on the preparation method.
Predicting superior crosses in winter wheat using genomics: A retrospective study to assess accuracy
Authors: Ballén‐Taborda Carolina , Lyerly Jeanette , Smith Jared , Howell Kimberly , Brown‐Guedira Gina , DeWitt Noah , Ward Brian , Babar Md Ali , Harrison Stephen A. , Mason Richard E. , Mergoum Mohamed , Murphy J. Paul , Sutton Russell , Griffey Carl A. , Boyles Richard E. 
Published: May 2024

AbstractIn plant breeding, selecting cross‐combinations that are more likely to result in superior lines for cultivar development is critical. This step, however, is subjective with decisions being based on available genomic and phenotypic data for prospective parents. Genomic prediction (GP) provides new opportunities to accelerate genetic gain for a target trait by identifying superior crosses through simulation of progeny performance. In this context, this study deployed GP using the phenotype and genotype of potential parents to predict the progeny genetic variance (VG) and means of overall, inferior 10%, and superior 10% (μ, μip, and μsp, respectively). This retrospective experimental design investigated whether the crosses that produced superior soft red winter wheat breeding lines would have been made if progeny simulations had guided crossing decisions of breeding programs. Here, data from historical wheat breeding lines were used to train GP models and predict VG and means for yield, test weight, heading date, and plant height for all combinations of 217 parents. Predicted and observed data for 670 lines derived from biparental crosses were compared to assess the accuracy of progeny simulations, and low‐to‐moderate prediction accuracy was observed for the four traits (0.25–0.52). Of the pedigrees that produced lines that were selected and advanced into later stage nurseries, 76% were predicted to give rise to progeny with above‐average yield. The moderate correlation found between predicted progeny means and observed line per se performance justifies using cross‐combination prediction as a tool to reduce crossing number and focus on segregating populations that harbor future cultivars.
Prediction of dementia risk from multimodal repeated measures: The added value of brain MRI biomarkers
Authors: Bercu Ariane , Dufouil Carole , Debette Stéphanie , Joliot Marc , Tsuchida Ami , Helmer Catherine , Devaux Anthony , Bouteloup Vincent , Proust‐Lima Cécile , Jacqmin‐Gadda Hélène 
Published: May 2024

AbstractThe utility of brain magnetic resonance imaging (MRI) for predicting dementia is debated. We evaluated the added value of repeated brain MRI, including atrophy and cerebral small vessel disease markers, for dementia prediction. We conducted a landmark competing risk analysis in 1716 participants of the French population‐based Three‐City Study to predict the 5‐year risk of dementia using repeated measures of 41 predictors till year 4 of follow‐up. Brain MRI markers improved significantly the individual prediction of dementia after accounting for demographics, health measures, and repeated measures of cognition and functional dependency (area under the ROC curve [95% CI] improved from 0.80 [0.79 to 0.82] to 0.83 [0.81 to 0.84]). Nonetheless, accounting for the change over time through repeated MRIs had little impact on predictive abilities. These results highlight the importance of multimodal analysis to evaluate the added predictive abilities of repeated brain MRI for dementia and offer new insights into the predictive performances of various MRI markers.Highlights
We evaluated whether repeated brain volumes and cSVD markers improve dementia prediction.
The 5‐year prediction of dementia is slightly improved when considering brain MRI markers.
Measures of hippocampus volume are the main MRI predictors of dementia.
Adjusted on cognition, repeated MRI has poor added value over single MRI for dementia prediction.
We utilized a longitudinal analysis that considers error‐and‐missing‐prone predictors, and competing death.
Cerebrospinal fluid soluble insulin receptor levels in Alzheimer's disease
Authors: Thomas Peter , Leclerc Manon , Evitts Kira , Brown Caitlin , Miller Wyatt , Hanson Angela J. , Banks William A. , Gibbons Laura , Domoto‐Reilly Kimiko , Jayadev Suman , Li Ge , Peskind Elaine , Young Jessica E. ,   the Consortium for the early identification of Alzheimer's disease‐Quebec (CIMA‐Q), Calon Frederic , Rhea Elizabeth M. 
Published: May 2024

AbstractINTRODUCTIONBrain insulin resistance and deficiency is a consistent feature of Alzheimer's disease (AD). Insulin resistance can be mediated by the surface expression of the insulin receptor (IR). Cleavage of the IR generates the soluble IR (sIR).METHODSWe measured the levels of sIR present in cerebrospinal fluid (CSF) from individuals along the AD diagnostic spectrum from two cohorts: Seattle (n = 58) and the Consortium for the Early Identification of Alzheimer's Disease‐Quebec (CIMA‐Q; n = 61). We further investigated the brain cellular contribution for sIR using human cell lines.RESULTSCSF sIR levels were not statistically different in AD. CSF sIR and amyloid beta (Aβ)42 and Aβ40 levels significantly correlated as well as CSF sIR and cognition in the CIMA‐Q cohort. Human neurons expressing the amyloid precursor protein “Swedish” mutation generated significantly greater sIR and human astrocytes were also able to release sIR in response to both an inflammatory and insulin stimulus.DISCUSSIONThese data support further investigation into the generation and role of sIR in AD.Highlights
Cerebrospinal fluid (CSF) soluble insulin receptor (sIR) levels positively correlate with amyloid beta (Aβ)42 and Aβ40.
CSF sIR levels negatively correlate with cognitive performance (Montreal Cognitive Assessment score).
CSF sIR levels in humans remain similar across Alzheimer's disease diagnostic groups.
Neurons derived from humans with the “Swedish” mutation in which Aβ42 is increased generate increased levels of sIR.
Human astrocytes can also produce sIR and generation is stimulated by tumor necrosis factor α and insulin.