bluuebunny/crossref_metadata_2025_split huggingface dataset:
Immunoinformatic evaluation for the development of a potent multi-epitope vaccine against bacterial vaginosis caused by Gardnerella vaginalis
Authors: Motamedi Hamid , Shoja Saeed , Abbasi Maryam 
Published: February 2025

Background
Bacterial vaginosis (BV) is the most common vaginal dysbiosis in fertile women, which is associated with side effects including the risk of premature birth. Gardnerella vaginalis (G. vaginalis) is a facultative anaerobic bacillus known as the main pathogen responsible for BV. In this study, using bioinformatics and immunoinformatics methods, a multi-epitope vaccine with optimal population coverage against BV caused by G. vaginalis was designed.

Methods
Amino acid sequences of two important virulence factors (Vaginolysin and Sialidase) of G. vaginalis were retrieved from NCBI and UniProt databases. At first, three online servers ABCpred, BCPREDS and LBtope were used to predict linear B-cell epitopes (BCEs) and IEDB server was used for T cells. Then the antigenicity, toxicity, allergenicity were evaluated using bioinformatics tools. After modeling the three-dimensional (3D) structure of the vaccine by Robetta Server, molecular docking and molecular dynamics were performed. Finally, immune simulation and in silico cloning were considered effective for the design of vaccine production strategy.

Results
In total, six epitopes of BCEs, eight epitopes from CD4+ and seven epitopes from CD8+ were selected. The designed multi-epitope vaccine was non-allergenic and non-toxic and showed high levels of antigenicity and immunogenicity. After the 3D structure was predicted, it was refined and validated, which resulted in an optimized model with a Z-score of -7.4. Molecular docking and molecular dynamics simulation of the designed vaccine revealed stable and strong binding interactions. Finally, the results of vaccine immunity simulation showed a significant increase in immunoglobulins, higher levels of IFN-γ and IL-2.

Conclusion
According to the findings, the candidate multi-epitope vaccine has stable structural features. It also has the potential to stimulate long-term immunity in the host, but wet-lab validation is needed to justify it.
Розвиток категоріально-понятійного апарату антикризового управління в контексті синергетичної парадигми
Authors: Шалений Володимир 
Published: February 2025

У статті досліджено трансформацію категоріально-понятійного апарату антикризового управління під впливом синергетичної парадигми. Важливо підкреслити, що зміни у категоріально-понятійному апараті антикризового управління відображають не лише еволюцію наукових підходів, а й глибокі трансформаційні процеси, що відбуваються у функціонуванні підприємств, галузей та економічних систем загалом. Відтак, дослідження розвитку КПА має враховувати як концептуальні зміни у теорії антикризового управління, так і практичні виклики, зумовлені нестабільністю економічного середовища. Обґрунтовано необхідність переосмислення традиційних визначень та концептів з урахуванням нелінійності економічних процесів та емерджентних властивостей складних систем. Розкрито взаємозв'язок між основними поняттями та категоріями, що формують теоретико-методологічну основу антикризового управління в умовах нелінійної динаміки економічних процесів. Обґрунтовано напрями подальшого розвитку категоріально-понятійного апарату для забезпечення більш глибокого розуміння механізмів самоорганізації та емерджентних властивостей складних систем в контексті антикризового управління.
Postural Risks and musculoskeletal discomfort of three preferred positions during laptop use amongst students
Authors: Hough PA , Nel Mariette 
Published: February 2025

The need to access information technology in modern day occupations has encouraged the use of laptops on a daily basis. It is assumed that using a laptop in a static position over a prolonged period of time may cause postural risk as well as musculoskeletal discomfort. A previous study identified 3 most preferred positions assumed during laptop use. This study investigates the postural risk involved during laptop use by students while assuming these 3 preferred positions. It also investigates the musculoskeletal discomfort experienced by students during laptop use as well as the methods students use to alleviate this discomfort. A quantitative, cross-sectional study design was used amongst a sample of 72 third year academic students from the University of the Free State. Data was collected by means of a self-administered questionnaire and the Rapid Upper Limb Assessment tool (RULA). For all 3 positions, 69.1% of participants scored in the postural risk category 3-4, indicating a low postural risk. Most (62.5%, n=45) participants experienced musculoskeletal discomfort with regard to pain or numbness, stiffness and spasms with 95% CI for prevalence [ 51.0% ; 72.8%]. Stiffness in the neck was experienced by 47.2% (n=34) participants and spasms in the neck experienced by 44.4% (n=32). Tendencies and statistical significant differences are indicated between genders for adaptations made during laptop use. A recommendation for further studies could be to investigate the postural risk involved while the students assume their most preferred posture within the 3 positions.
KEYWORDS: laptop, university students, Rapid Upper Limb Assessment (RULA), postural risk, musculoskeletal discomforts
Hysterectomy with trans-cervical resection of a prolapsed submucosal fibroid: a challenging surgical approach
Authors: Dhandapani Kalyani Sai , Sezhian Varshini 
Published: February 2025

Uterine fibroids or leiomyomas, are the common benign tumors of female reproductive tract that affects women of almost all age groups, leading to various gynecological problems such as heavy menstrual bleeding, dysmenorrhea, subfertility, and anemia. The increasing prevalence of these fibroids, due to prolonged estrogen exposure, influenced by lifestyle factors such as obesity, alcoholism, nulliparity and medical conditions like hypertension, have made necessitate their timely management to reduce significant morbidity. Surgical interventions, particularly hysterectomy, are considered definitive for women of perimenopausal and postmenopausal age group with symptomatic fibroids, though challenging due to the altered uterine anatomy. Here we present a case of a 46-year-old woman, P2L2, who reported with a history of heavy menstrual bleeding, dysmenorrhea, and intermenstrual bleeding, along with anemia (Hb 8.4 g/dL). Ultrasonography revealed a bulky uterus with multiple intramural fibroids and a prolapsed submucosal fibroid protruding through the cervical OS which bled on touch. She underwent a successful abdominal hysterectomy, with a unique surgical approach to manage the prolapsed submucosal fibroid. A vertical incision on the anterior cervix facilitated the clamping and removal of the pedunculated fibroid through the vagina, followed by its removal with minimal blood loss. This case highlights the importance of accurate preoperative imaging and surgical planning and use of surgical strategies such like this to improve operative outcomes and reduce morbidity, especially in anemic patients.
Tatwiru Al-Qomusy Al-'Arobiy - Al-Indunisy Lil Ustazi Ad-Duktur Mahmud Yunus 'ala Asasil Madholi Ilmu Shorfi (Morphology) Al-Lawniy Litthullabi Qismu Ta'lim Al-Lughah 'Al-Arobiyyah Fiil Jami'ah Islamiyyah Bangkalish
Authors: Susanti Triana , Ulfa Marhamah 
Published: February 2025

???? ??? ????? ??? ????? ??????? ?????? ?????????? ???????. ???????. ????? ???? ??? ???? ?????? ??? ????? (Morphology) ??????. ??????? ?? ??? ????? ?? ?????? ???? ?? ????? ??? ??????? ???????. ??? ????? ?????? ???? ????? ???????? ?????? ????? 4D ???? ????? ?? ????? ????? : ??????? ???????? ???????? ??????. ?????? ??? ???????? ???????? ???????? ??????????? ??? ???? ????? ???????? ???????? ??????? ????????. ?????? ??? ?????:(1) ?? ????? ??????? ?????? - ?????????? ???????. ???????. ????? ???? ??? ???? ?????? ??? ????? (Morphology) ?????? ????? ?? ????? ?????????? ??? ????? ?????? ?????? ?? ?????? ??? ????? ??????? ?????? ???????.(2) ?? ?????? ?? ??? ????? ??????? ?????? - ?????????? ???????. ???????. ????? ???? ??? ???? ?????? ??? ????? (Morphology) ?????? ?? ??? ??????? ????? ?? ???? ???? ????? ??????? ?????? ?? ????? ?????? ???????? ??? ???? ????? ?????? ?? ???????? "?????" ? ??? ???? ?? ??? ??????? ????? ?????????? ?? ????? ??????.
The Value of Religious Moderation in Compulsory Wills to Non-Muslims Through the Application of Maqasid Shari'ah
Authors: Agustiar  
Published: February 2025

This research examined decision number 263/P.Dt.G/2007/Pta.Sby to identify the values of religious moderation implemented by the judge. This research aims to find out and analyze the values of religious moderation in the granting of mandatory wills to non-Muslims through the application of maqasid al-syari'ah in decision number 263/P.Dt.G/2007/Pta.Sby. The source of information regarding this matter is decision number 263/p.dt.g/2007/pta.sby. The decision was analyzed using content analysis. The steps taken are collecting data, organizing it, presenting it in writing, and drawing conclusions. The research findings show that the value of religious moderation implemented by religious court judges in the decision above, have a positive impact includes: maintaining peace and stability in the family environment, promoting peace and prosperity in society, ensuring the protection of property, providing protection for religious interests, protecting the existence of family harmony, and ensuring social justice in the community, and reflecting the flexibility of Islamic teachings.
Tarqiyyatu Istii'aabi al-Mufradaat al-'Arabiyyat 'Ibr Barnaamaj al-Haatif al-Dzakiyy
Authors: Rokhani Rokhani , Zuhrudin Achmad , Shiddiq Jamaluddin 
Published: February 2025

This development research aims to produce learning media mobile learning based on Android for students as well as to know the quality of mobile learning media products that have been produced so feasible use in vocabulary learning. This study is a research development or Research and Development (R & D) adapted from ADDIE development model. The stages are 5 stages: 1) Analysis, 2) Design, 3) Development, 4) Implementation, and 5) Evaluation. As for the general procedures in designing this application program, it is divided into three: collecting data, recording data using Adobe Flash CS6, and entering coding, or we call it an Action Script. Validation is done by material experts and media experts and students. The results showed that the learning media mobile learning based on Android that has been developed based on the assessment of media experts 84 % with the category of Excellent and the material expert assessment of 86.9 % with Excellent category. And also students assessment of 94.9 % with Excellent category

الملخص
يهدف بحث التطوير هذا إلى إنتاج تعليم متنقل للوسائط التعليمية يعتمد على Android للطلاب بالإضافة إلى معرفة جودة منتجات وسائط التعلم المحمولة التي تم إنتاجها بحيث يمكن استخدامها في تعلم المفردات. هذه الدراسة عبارة عن تطوير بحث أو بحث وتطوير مقتبس من نموذج تطوير ADDIE. المراحل 5: 1) التحليل ، 2) التصميم ، 3) التطوير ، 4) التنفيذ ، 5) التقييم. أما بالنسبة للإجراءات العامة في تصميم هذا البرنامج التطبيقي ، فهي تنقسم إلى ثلاثة: جمع البيانات ، وتسجيل البيانات باستخدام Adobe Flash CS6 ، وإدخال الترميز ، أو نسميها Action Script. يتم التحقق من صحة المواد من قبل خبراء المواد وخبراء الإعلام والطلاب. وأظهرت النتائج أن التعلم عبر وسائل الإعلام المتنقلة القائم على نظام أندرويد تم تطويره بناءً على تقييم خبراء الإعلام 84٪ بفئة ممتاز وتقييم خبير المادة 86.9٪ بفئة ممتاز. وكذلك تقييم الطلاب 94.9٪ بفئة ممتازة
Memahami Konsep Tasybîh dalam Al-Quran: Perspektif Ahli Tafsir dan Implikasinya Bagi Pengembangan Materi Ajar Ilmu Bayan
Authors: Abdurahman Rizki , Sabarudin Ikbal , Hardianti Mida 
Published: February 2025

The concept of tasybîh in bayan science needs to be studied more deeply regarding theory and application in understanding Quranic verses. This study aims to describe the concept of tasybîh in the Quran according to the views of exegetes as material for the development of bayan science teaching materials. This research uses a descriptive qualitative approach with a literature study method. The primary data sources in this study are books that discuss Quranic balaghah, namely al-Itqan fi Ulum al-Quran, Shafwat al-Tafasir, Tafsir al-Munir, and al-I'jaz al-Balaghi. The secondary sources consist of articles, books, and books related to the research topic. The data analysis technique is carried out with a content analysis model through the stages of (1) analysing and compiling data on tasybîh verses in the Quran according to the views of exegetes and (2) describing their implications for the development of bayan teaching materials. The results of this study indicate that there are several tasybîh verses in the Quran according to the views of exegetes in the four books above with various kinds of tasybîh in the perspective of bayan science, such as tasybîh mursal mujmal, tasybîh mursal mufashshal, tasybîh baligh, tasybîh tamtsili, tasybîh maqlub, and tasybîh dhimni. The results of this research data have significant contributions and implications for efforts to develop teaching materials based on Quranic studies.
Abstrak
Konsep tasybîh dalam ilmu bayan perlu dikaji lebih mendalam dari segi teori dan aplikasinya dalam memahami ayat-ayat Al-Quran. Penelitian ini bertujuan untuk mendeskripsikan konsep tasybîh dalam Al-Quran menurut pandangan ahli tafsir sebagai bahan pengembangan materi ajar ilmu bayan. Penelitian ini menggunakan pendekatan deskriptif kualitatif dengan metode studi pustaka. Sumber data primer dalam penelitian ini adalah kitab-kitab yang membahas balaghah Al-Quran, yaitu: al-Itqan fi Ulum al-Quran, Shafwat al-Tafasir, Tafsir al-Munir, dan al-I’jaz al-Balaghi. Sumber sekundernya terdiri dari artikel, buku, dan kitab yang terkait dengan topik penelitian. Teknik analisis data dilakukan dengan model analisis isi melalui tahapan (1) menganalisis dan menghimpun data ayat-ayat tasybîh dalam Al-Quran menurut pandangan ahli tafsir dan (2) mendeskripsikan implikasinya terhadap pengembangan materi ajar ilmu bayan. Hasil penelitian ini menunjukkan bahwa ada beberapa ayat-ayat tasybîh dalam Al-Quran menurut pandangan ahli tafsir dalam empat kitab di atas dengan berbagai macam tasybîh dalam perspektif ilmu bayan, seperti tasybîh mursal mujmal, tasybîh mursal mufashshal, tasybîh baligh, tasybîh tamtsili, tasybîh maqlub, dan tasybîh dhimni. Hasil data penelitian ini memiliki kontribusi yang siginifikan dan berimplikasi terhadap upaya pengembangan materi ajar ilmu bayan berbasis kajian Al-Quran
The Construction of Resistance in Ibrahim Touqan's “Mawtini” Song Lyrics: New Historicism Analysis
Authors: Lestari Septi , Yurisa Penny Respati 
Published: February 2025

The hegemonic attempts made by the British and European Jews triggered resistance from the Palestinian people. The resistance is manifested in physical and non-physical struggles, including literary works. This research aims to reveal the construction of resistance in Ibrahim Touqan's Mawtini by using the theory of New Historicism by Stephen Greenblatt. Literary readings are juxtaposed with non-literary texts in order to find the historical background of colonialism in Palestine in the British Mandate era and the diaspora of Jews from Europe. This research is a descriptive qualitative type. The data of this research is in the form of mawtini song lyrics which are then read together with two non-literary books to understand the historical substance behind the song lyrics. Based on the results of the research, it was found that the construction of resistance in this song is structured through the perspective of the people seeing their homeland, the hope for a resolution to the conflict, the importance of the role of youth to fight, the purpose of the resistance and the methods taken in resistance to hegemony efforts over the land of Palestine.
Abstrak
Upaya hegemoni yang dilakukan oleh Inggris dan Yahudi Eropa memicu perlawanan dari rakyat Palestina. Perlawanan tersebut diwujudkan dalam perjuangan fisik dan non-fisik, termasuk di dalamnya adalah karya sastra. Penelitian ini bertujuan untuk mengungkapkan konstruksi perlawanan di dalam lirk lagu Mawtini karya Ibrahim Touqan dengan menggunakan teori New Historicism oleh Stephen Greenblatt. Pembacaan sastra disandingkan dengan teks non sastra agar menemukan latar belakang sejarah kolonialisme di Palestina di era Mandat Inggris serta diaspora kaum Yahudi dari Eropa. Penelitian ini berjenis kualitatif deskriptif. Data penelitian ini berupa lirik lagu mawtini yang kemudian dibaca bersamaan dengan dua buku non-sastra untuk memahami substansi sejarah di balik lirik lagu tersebut. Data dikumpulkan menggunakan teknik baca-catat. Sedangkan teknik analis data melalui tahap reduksi data, penyajian, dan penarikan kesimpulan. Berdasarkan hasil penelitian, ditemukan konstruksi perlawanan di dalam lagu ini disusun melalui perspektif rakyat melihat tanah airnya, harapan adanya resolusi atas konflik, pentingnya peran pemuda untuk melakukan perlawan, tujuan dari perlawanan tersebut serta cara-cara yang ditempuh dalam melakukan perlawanan terhadap upaya hegemoni di atas negeri Palestina.
Tashmim Kitab Al-Jaib “Dhiya’ul Muta’allimin” Li Muhadatsah Al-Thullab Fi Al-Ma’had Al-Islamiyah Al-Hasaniyah Ponorogo
Authors: Tricahyo Agus , Mukaromah Muhimmatul , Wahidah Zulvata Kholifatul 
Published: February 2025

This study aims to determine the design of the Muhadatsah book and the effectiveness of its use at Al-Hasanah Islamic Boarding School. This study uses the Research and Development (R&D) method and data collection using observation, interviews, questionnaires, and tests. The test subjects consisted of material experts, learning design experts, linguists, and 3rd-grade students of Al-Hasanah Islamic boarding school as the target of testing the Arabic conversation product dhiyaul muta'alimin. The results of this study show: 1) The product designed is an Arabic conversation pocket book, "Dhiyaul Muta'alimin", designed to be simple, attractive, and small in size so that it is easy to carry. The material contained in the pocketbook "Dhiyaul Muta'alimin" is the daily conversation material of the santri in the dormitory and is equipped with 'amiya Arabic expressions (the daily language of the Arabs), which will add insight to the santri. 2) Using the pocketbook "Dhiyaul Muta'alimin" in the third grade of Al-Hasanah boarding school is effective. This is shown by the evidence that the results of statistical tests before and after using the "Dhiyaul Muta'alimin" muhadatsah pocketbook increased. Namely the results of the Wilcoxon statistical test in the experimental group given the "Dhiyaul Muta'alimin" pocketbook is the sig value (0.00) < alpha (0.05) so it can be concluded that there is an effect of the "Dhiyaul Muta'alimin" muhadatsah pocket book on student learning outcomes.
Abstrak
Penelitian ini bertujuan untuk mengetahui perancangan buku Muhadatsah dan efektivitas penggunaannya di Pondok Pesantren Al-Hasanah. Penelitian ini menggunakan metode penelitian Research and Development (R&D) dan pengumpulan data menggunakan observasi, wawancara, angket, dan tes. Subjek uji coba terdiri dari ahli materi, ahli desain pembelajaran, ahli bahasa, dan siswa kelas 3 pondok pesantren Al-Hasanah sebagai sasaran uji coba produk percakapan bahasa Arab dhiyaul muta'alimin. Hasil penelitian ini menunjukkan: 1) Produk yang dirancang adalah Buku saku percakapan bahasa Arab “Dhiyaul Muta’alimin” yang didesain simple, menarik, dan berukuran kecil sehingga mudah untuk dibawa. Materi yang terdapat dalam buku saku “Dhiyaul Muta’alimin” adalah materi percakapan keseharian santri di asrama, dan dilengkapi dengan ungkapan kata bahasa Arab ‘amiyah (bahasa keseharian orang Arab) yang akan menambah wawasan bagi santri. 2) Penggunaan buku saku “Dhiyaul Muta’alimin” di kelas tiga pondok pesantren Al-Hasanah berjalan efektif. Hal ini ditunjukkan dengan bukti bahwa hasil uji statistik antara sebelum dan sesudah menggunakan buku saku muhadatsah “Dhiyaul Muta’alimin” meningkat, yaitu hasil uji statistik wilcoxon pada kelompok eksperimen yang diberikan buku saku “Dhiyaul Muta’alimin” adalah nilai sig (0.00)< alpha (0.05) sehingga bisa disimpulkan bahwa ada pengaruh dari buku saku muhadatsah “Dhiyaul Muta’alimin” pada hasil belajar siswa.
The Victimology of 10 Victims in The Novel "ثمّ لم يبق أحد" by Agatha Christie Based on the Perspective of Benjamin Mendelsohn
Authors: Widyasari Rintina , Zawawi Moh 
Published: February 2025

The murder victims in the novel ثمّ لم يبق أحد have their own dark secrets. They were invited to a house located on Warrior Island without the slightest suspicion. The invited victims have been targeted to be killed for what they did in the past. The purpose of this study is to describe the form of guilt of the victim according to the category of guilt in the novel ثمّ لم يبق أحد by Agatha Christie based on Mendelsohn's perspective. This type of research is descriptive qualitative. The primary data source used is Agatha Christie's novel ثمّ لم يبق أحد, while the secondary data source is articles, books and other literature sources on victimology studies. The data collection technique used is a reading and recording technique. The data analysis techniques used are data reduction, data presentation and conclusions. The findings in the novel "ثمّ لم يبق أحد " based on Mendelsohn's victimological perspective are known to have 3 categories of forms of victim guilt, namely: 1) the category of victims with a minimum level of guilt is found in 3 figures, namely Anthony Marston, Ethel Rogers and General MacArthur; 2) the category of guilt of the victim is the same as the perpetrator found in 4 figures namely Thomas Rogers, Emily Brent, Edward Armstrong, and Judge Wargrave; and 3) the category of victims with a greater degree of guilt than the perpetrator is found in 3 figures, namely William Blore, Philip Lombard and Vera Claythrone
Abstrak
Korban pembunuhan dalam novel ثمّ لم يبق أحد memiliki rahasia kelamnya masing-masing. Mereka diundang ke sebuah rumah yang berada di Pulau Prajurit tanpa curiga sedikitpun. Para korban yang diundang tersebut sudah ditargetkan untuk dibunuh atas apa yang mereka lakukan di masa lalu. Tujuan dari penelitian ini adalah mendeskripsikan bentuk kesalahan korban dalam novel ثمّ لم يبق أحد karya Agatha Christie berdasarkan perspektif Mendelsohn. Jenis penelitian ini adalah deskriptif kualitatif. Sumber data primer yang digunakan adalah novel ثمّ لم يبق أحد karya Agatha Christie, sedangkan sumber data sekunder adalah artikel, buku dan sumber literature lainnya tentang kajian viktimologi. Teknik pengumpulan data yang digunakan adalah teknik baca dan catat. Adapun teknik analisis data yang digunakan adalah reduksi data, penyajian data dan penarikan kesimpulan. Hasil temuan menunjukkan terdapat 3 kategori bentuk kesalahan korban yaitu: 1) kategori korban dengan kadar kesalahan minimal ditemukan dalam 3 tokoh yaitu Anthony Marston, Ethel Rogers dan Jenderal MacArthur; 2) kategori kesalahan korban sama dengan pelaku ditemukan dalam 4 tokoh yaitu Thomas Rogers, Emily Brent, Edward Amstrong, dan Hakim Wargrave; dan 3) kategori korban dengan kadar kesalahan lebih besar dari pelaku ditemukan dalam 3 tokoh yaitu William Blore, Philip Lombard dan Vera Claythrone