bluuebunny/crossref_metadata_2025_split huggingface dataset:
Novel 5‐Methyl‐2‐[(un)substituted phenyl]‐4‐{4,5‐dihydro‐ 3‐[(un)substituted phenyl]‐5‐(1,2,3,4‐tetrahydroisoquinoline‐2‐yl)pyrazol‐1‐yl}‐oxazole Derivatives: Synthesis and Anticancer Activity
Authors: Liu Xinhua , Bai Linshan , Pan Chunxiu , Song Baoan , Zhu Hailiang 
Published: October 2009

AbstractEleven novel 5‐methyl‐2‐[(un)substituted phenyl]‐4‐{4,5‐dihydro‐3‐[(un)substituted phenyl]‐5‐(1,2,3,4‐tetrahydroisoquinoline‐2‐yl)pyrazol‐1‐yl}‐oxazole derivatives were synthesized and characterized by elemental analysis, ESI‐MS, 1H NMR and 13C NMR. All of the compounds have been screened for their antiproliferative activities against PC‐3 cell (human prostate cancer) and A431 cell (human epidermoid carcinoma cancer) lines in vitro. The results revealed that compounds 4g, 4j and 4k exhibited the strong inhibitory activities against the PC‐3 cell lines (with IC50 values of 2.8±0.11, 3.1±0.10 and 3.0±0.06 μg/mL, respectively).
Ga(OTf)3‐catalyzed Three‐component Mannich Reaction in Water Promoted by Ultrasound Irradiation
Authors: Zhang Guangliang , Huang Zhihao , Zou Jianping 
Published: October 2009

AbstractGa(OTf)3‐catalyzed three‐component Mannich reaction of aromatic aldehydes, aromatic amines and cycloketones in water promoted by ultrasound gave the corresponding β‐amino cycloketones in good to excellent yields and good anti selectivities.
Sorption of Pb(II) on Mg‐Fe Layered Double Hydroxide
Authors: Liang Xuefeng , Hou Wanguo , Xu Jie 
Published: October 2009

AbstractMg‐Fe layered double hydroxide (LDH) with a Mg/Fe molar ratio of 3:1 was synthesized by using a coprecipitation method and the sorption removal of Pb(II) by the LDH sample from Pb(NO3)2 solution was investigated. It was found that Mg‐Fe LDH showed a good sorption ability for Pb(II) from Pb(NO3)2 solution, indicating that the use of LDH as a promising inorganic sorbent for the removal of heavy metal ions is possible. The sorption kinetics and the sorption isotherm of Pb(II) on the LDH sample obeyed the pseudo‐second order kinetic model and Aranovich‐Donohue equation, respectively. The sorption mechanism of Pb(II) on the LDH may be attributed to the surface‐induced precipitation and the chemical binding adsorption, and the removal ability arising from the surface‐induced precipitation is much higher than that from the chemical binding adsorption.
Homo‐coupling of Aryl Iodide and Bromide Catalyzed by Immobilized Palladium with a Bidentate Nitrogen Ligand
Authors: Chen Xiaofang , Wang Lei 
Published: October 2009

AbstractThe immobilized palladium onto organic‐inorganic hybrid material, which contains bidentate nitrogen ligands, was a very effective catalyst for homo‐coupling of aryl iodide and bromide. The protocol involved the use of N,N‐dimethylacetamide as a solvent, and n‐tributylamine as a base. The reaction generated the corresponding homo‐coupling products in good to excellent yields at low catalyst loading (0.20 mol%). Furthermore, the silica‐supported palladium catalyst could be recovered and recycled by a simple filtration of the reaction solution and used for five consecutive trials without loss of its activity.
Synthesis of 1,4‐Benzothiazine Compounds Containing Isatin Hydrazone Moiety as Antimicrobial Agent
Authors: Sonawane Atul E. , Pawar Yogesh A. , Nagle Pramod S. , Mahulikar Pramod P. , More Dhananjay H. 
Published: October 2009

AbstractA series of novel 3‐methyl‐N"‐(2‐oxoindolin‐3‐ylidene)‐4H‐benzo[b][1,4]thiazine‐2‐carbohyrazides have been synthesized and studied on their in vitro antimicrobial activity potency to establish structure‐activity relationship. Several compounds demonstrated promising antifungal and antibacterial activity; however, other tested compounds exhibited moderate to poor antimicrobial activity with respect to the reference drug against the test strains.
Determination of Copper and Zinc Ions by Flame‐AAS After Preconcentraction Using Sodium Dodecyl Sulfate Coated Alumina Modified with 3‐((1H‐Indol‐3‐yl)‐3,4,5‐trimethyl)‐1H‐indole
Authors: Ghaedi Mehrorang , Tavallali Hossein , Keshavarz M. , Niknam K. 
Published: October 2009

AbstractA sensitive and simple method for the simultaneous preconcentration of trace amount Cu2+ and Zn2+ ions in some real samples has been established, which is based on the sorption of Cu2+ and Zn2+ on 3‐((1H‐indol‐3‐yl)‐3,4,5‐trimethyl)‐1H‐indole (ITMI) loaded on sodium dodecyl sulfate (SDS) coated alumina. The metal absorbed on the complexes was eluted using 3 mol/L nitric acid. The influences of the analytical parameters including pH and sample volume were investigated. The effects of matrix ions on the retentions of the analytes were also examined. The recoveries of analytes were generally higher than 95% with a low RSD. The method has been successfully applied to content evaluation of these metals in real samples.
Synthesis of Novel Bromo‐substituted Flavone‐like Troponoid Compounds from Oxidation Cyclization of 3‐Cinnamoyl‐5,7‐dibromotropolones Using I2/DMSO/H2SO4 System
Authors: Li Yang , Chang Mingqin , Sun Mingchun , Li Wei , Gao Wentao 
Published: October 2009

AbstractA convenient method to obtain a series of bromo‐substituted flavone‐like troponoid compounds 6,8‐dibromo‐2‐arylcyclohepta[b]pyran‐4,9‐diones 3a–3s by oxidation cyclization of the readily available intermediates 3‐cinnamoyl‐5,7‐dibromotropolones 2a–2s using I2/DMSO/H2SO4 system was realized. Compounds 2a–2s were obtained from the aldol reaction of 3‐acetyl‐5,7‐dibromotropolone 1 with various benzaldehydes. Compounds 2a–2s and 3a–3s are novel and their structures were supported by IR, 1H NMR, MS and elemental analyses.
Homology Modeling of Cyt2Ca1 of Bacillus thuringiensis and Its Molecular Docking with Inositol Monophosphate
Authors: Zhao Xinming , Xia Liqiu , Ding Xuezhi , Yu Ziquan , LÜ Yuan , Tao Wenna 
Published: October 2009

AbstractCyt2Ca1 is an insecticidal crystal protein produced by Bacillus thuringiensis ET29 during its stationary phase, and this δ‐endotoxin demonstrates remarkable insecticidal activity against not only insects of the order Coleoptera, but also against fleas, and in particular the larvae of the cat flea, Ctenocephalides felis. The first theoretical model of the three‐dimensional structure of Cyt2Ca1 was predicted and compared with Cyt2Aa, which is lethal to insect larvae. The three‐dimensional structure of the Cyt2Ca1 was obtained by homology modeling on the structures of the Cyt2Aa protein. The deduced model resembles previously reported Cyt2Aa toxin. A binding mode of inositol monophosphate as a polar head group of the putative membrane phospholipid ligand to Cyt2Ca1 was presented using molecular docking. The residues of Leu9, Glu21, Tyr23 and Gln110 of the Cyt2Ca1 toxin are responsible for the interactions with inositol monophosphate via eight hydrogen bonds. Those residues could be important for receptor recognition. This binding simulation will be helpful for the design of mutagenesis experiments aimed at the improvement of toxicity, and lead to a deep understanding of the mechanism of action of Cyt toxins.
Synthesis and Photosensitive Properties of Poly(aryl imino) Containing Azobenzene Group (PAI‐A)
Authors: Chen Xiaoquan , Chang Guanjun 
Published: October 2009

AbstractUsing 4,4′‐dibromobenzophenone and 4,4′‐diaminoazobenzene as monomers, poly(aryl imino) containing azobenzene unit (PAI‐A) was synthesized via palladium‐catalyzed amination, and structurally characterized by means of FT‐IR, 1H NMR spectra and elemental analysis, the results of which show an agreement with the proposed structure. The UV absorption spectra were tested under different conditions. Additionally, differential scanning calorimetry (DSC) and thermogravimetric (TG) measurements show that PAI‐A possesses high glass transition temperature (Tg>176°C) and good thermal stability with high decomposition temperatures in nitrogen atmosphere (TD>410°C).
Crystal Structure of β‐Cyclodextrin‐Felbinac Inclusion Complex
Authors: Wang Enju , Chen Guangying , Liu Hong 
Published: October 2009

AbstractThe crystal structure of the inclusion complex of β‐cyclodextrin (β‐CD) synthesized with felbinac (4‐biphenylacetic acid) was determined by single crystal X‐ray diffraction at 150 K. The complex contains two β‐CDs, two felbinac molecules, twenty‐two water molecules in the asymmetric unit, and could be formulated as (C42H70O35)2·(C14H12O2)2·22(H2O). In the crystal lattice, the two β‐CD moieties form a head‐to‐head dimer jointed through hydrogen bonds, and the felbinacs that interact by face‐to‐face Π‐Π stacking are included in the β‐CD dimer cavity with their carboxyl groups protruding out from cavity opening. In crystals the dimer units of β‐CD are stacked in an intermediate type (IM) that consists of closely packed β‐CD dimer layers.
Thermodynamics of Carbon Dioxide Adsorption on the Protonic Zeolite H‐ZSM‐5
Authors: Armandi Marco , Garrone Edoardo , Areán Carlos O. , Bonelli Barbara 
Published: October 2009

AbstractAdsorption of carbon dioxide on H‐ZSM‐5 zeolite (Si:Al=11.5:1) was studied by means of variable‐temperature FT‐IR spectroscopy, in the temperature range of 310–365 K. The adsorbed CO2 molecules interact with the zeolite Brønsted‐acid OH groups bringing about a characteristic red‐shift of the OH stretching band from 3610 cm−1 to 3480 cm−1. Simultaneously, the ν3 mode of adsorbed CO2 is observed at 2345 cm−1. From the variation of integrated intensity of the IR absorption bands at both 3610 and 2345 cm−1, upon changing temperature (and CO2 equilibrium pressure), the standard adsorption enthalpy of CO2 on H‐ZSM‐5 is ΔH0=−31.2(±1) kJ mol−1 and the corresponding entropy change is ΔS0=−140(±10) J mol−1 K−1. These results are discussed in the context of available data for carbon dioxide adsorption on other protonic, and also alkali‐metal exchanged, zeolites.
Rational Design of Ag/TiO2 Nanosystems by a Combined RF‐Sputtering/Sol‐Gel Approach
Authors: Armelao Lidia , Barreca Davide , Bottaro Gregorio , Gasparotto Alberto , Maccato Chiara , Tondello Eugenio , Lebedev Oleg I. , Turner Stuart , Van Tendeloo Gustaaf , Sada Cinzia , Štangar Urška Lavrenčič 
Published: October 2009

AbstractThe present work is devoted to the preparation of Ag/TiO2 nanosystems by an original synthetic strategy, based on the radio‐frequency (RF) sputtering of silver particles on titania‐based xerogels prepared by the sol–gel (SG) route. This approach takes advantage of the synergy between the microporous xerogel structure and the infiltration power characterizing RF‐sputtering, whose combination enables the obtainment of a tailored dispersion of Ag‐containing particles into the titania matrix. In addition, the system′s chemico‐physical features can be tuned further through proper ex situ thermal treatments in air at 400 and 600 °C. The synthesized composites are extensively characterized by the joint use of complementary techniques, that is, X‐ray photoelectron and X‐ray excited Auger electron spectroscopies (XPS, XE‐AES), secondary ion mass spectrometry (SIMS), glancing incidence X‐ray diffraction (GIXRD), field emission scanning electron microscopy (FE–SEM), transmission electron microscopy (TEM), electron diffraction (ED), high‐angle annular dark field scanning TEM (HAADF–STEM), energy‐filtered TEM (EF–TEM) and optical absorption spectroscopy. Finally, the photocatalytic performances of selected samples in the decomposition of the azo‐dye Plasmocorinth B are preliminarily investigated. The obtained results highlight the possibility of tailoring the system characteristics over a broad range, directly influencing their eventual functional properties.
Preparation and characterization of monodispersed PbSe nanocubes
Authors: Wang Xinjun , Li Ke , Dong Yutao , Jiang Kai 
Published: October 2009

AbstractMonodispersed PbSe nanocubes were synthesized through a simple hydrothermal method by using Pb2+‐EDTA complex and Na2SeSO3. Composition and morphology of the samples were characterized by means of XRD, TEM and SEM. The gradually releasing of Pb2+ from Pb2+‐EDTA complex, and the adopting of PVP can adjust the growth rate in <100> and <111> directions of PbSe. Both Pb2+‐EDTA complex and PVP played important roles in the crystal growth of the monodispersed PbSe nanocubes. In addition, UV‐vis and photoluminescence properties were characterized. Eg of the PbSe nanocubes is 1.5 eV approximately, which is much larger than that of bulk PbSe. Under PL excitation at 406 nm, a red emission peak at 696 nm is observed, showing that the synthesized PbSe is luminescent nanomaterials. (© 2010 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Robust marking of photoreceptor cells and pinealocytes with several reporters under control of the Crx gene
Authors: Samson Maria , Emerson Mark M. , Cepko Constance L. 
Published: October 2009

AbstractCrx is a member of the Otx family of homeobox genes with expression restricted to vertebrate retinal photoreceptor and bipolar cells as well as the pinealocytes of the pineal organ. To facilitate the visualization of Crx‐expressing cells, we generated transgenic mice expressing several reporters under the control of the Crx regulatory sequences present within a bacterial artificial chromosome (BAC). These mice expand the transgenic mouse collection, which uses photoreceptor regulatory elements for reporter gene expression by providing a broader repertoire of reporter genes. In addition, because Crx is expressed very soon after a cell fated to be a photoreceptor cell becomes postmitotic, they provide a means for early identification of immature photoreceptor cells. Developmental Dynamics 238:3218–3225, 2009. © 2009 Wiley‐Liss, Inc.
The evolution of gnathostome development: Insight from chondrichthyan embryology
Authors: Gillis J. Andrew , Shubin Neil H. 
Published: October 2009

AbstractChondrichthyans (cartilaginous fishes) represent one of the two lineages of gnathostomes, the other being the osteicthyans (bony fishes). Classical studies on chondrichthyan embryology have strongly impacted our views of vertebrate body plan evolution, while recent studies highlight oviparous chondrichthyans as emerging vertebrate model systems that are amenable to experimental embryological manipulation. Here, we review three particular areas of interest in the field of chondrichthyan developmental biology—gastrulation, neural development, and appendage patterning—and we discuss recentfindings within a broader chondrichthyan‐osteichthyan comparative framework. In some cases, comparative studies of chondrichthyan and osteichthyan development reveal conserved patterns of gene expression in common developmental contexts. Studies of chondrichthyan gastrulation reveal conserved patterns of developmental gene expression, despite highly divergent modes of mesendoderm internalization, while molecular characterization of chondrichthyan neurogenic placodes indicates a conservation of placode transcription factor expression across gnathostome phylogeny. In other cases, comparative studies of chondrichthyan and osteichthyan development yield evidence of shared patterning mechanisms functioning in different developmental contexts. This is exemplified by studies on the development of chondrichthyan appendages—paired fins, median fins, and gill rays. These have demonstrated that a retinoic acid‐responsive Shh‐expressing signaling center functions to pattern the endoskeleton of gnathostome paired fins and chondrichthyan gill rays, while expression patterns of Tbx18 and HoxD family members are shared by gnathostome paired fins and chondrichthyan median fins. These findings fuel novel hypotheses of developmental genetic homology, and demonstrate how comparative studies of gnathostome development can provide insight into the evolutionary processes that underlie morphological diversity. genesis 47:825–841, 2009. © 2009 Wiley‐Liss, Inc.
Textpresso site‐specific recombinases: A text‐mining server for the recombinase literature including Cre mice and conditional alleles
Authors: Urbanski William M. , Condie Brian G. 
Published: October 2009

AbstractTextpresso Site Specific Recombinases (http://ssrc.genetics.uga.edu/) is a text‐mining web server for searching a database of more than 9,000 full‐text publications. The papers and abstracts in this database represent a wide range of topics related to site‐specific recombinase (SSR) research tools. Included in the database are most of the papers that report the characterization or use of mouse strains that express Cre recombinase as well as papers that describe or analyze mouse lines that carry conditional (floxed) alleles or SSR‐activated transgenes/knockins. The database also includes reports describing SSR‐based cloning methods such as the Gateway or the Creator systems, papers reporting the development or use of SSR‐based tools in systems such as Drosophila, bacteria, parasites, stem cells, yeast, plants, zebrafish, and Xenopus as well as publications that describe the biochemistry, genetics, or molecular structure of the SSRs themselves. Textpresso Site Specific Recombinases is the only comprehensive text‐mining resource available for the literature describing the biology and technical applications of SSRs. genesis 47:842–846, 2009. © 2009 Wiley‐Liss, Inc.
Apoptosis of glomerular mesangial cells induced by sublytic C5b‐9 complexes in rats with Thy‐1 nephritis is dependent on Gadd45γ upregulation
Authors: Qiu Wen , Che Nan , Feng Xuefeng , Xia Mei , Wang Hui , Zhao Dan , Wang Yingwei 
Published: October 2009

AbstractThe complement C5b‐9 complexes can result in cell apoptosis, but the mechanism of sublytic C5b‐9‐mediated glomerular mesangial cell (GMC) apoptosis in Thy‐1 nephritis (Thy‐1N) remains largely unclear. The Gadd45 gene is involved in the cellular response to DNA damage and can promote cell apoptosis. In this study, both Gadd45γ expression patterns and pathologic changes of renal tissue were examined in rat Thy‐1N. Both Gadd45γ expression and GMC apoptosis were significantly decreased in Thy‐1N rats upon the depletion of complement with cobra venom factor. Our in vitro studies showed that Gadd45γ over‐expression increased sublytic C5b‐9‐induced GMC apoptosis, while Gadd45γ gene knockdown by siRNA greatly reduced GMC apoptosis. Moreover, Gadd45γ gene silencing in vivo markedly inhibited the pathologic changes in the renal tissue of Thy‐1N rats. These data suggest that Gadd45γ gene expression is involved in regulating GMC apoptosis mediated by sublytic C5b‐9 in Thy‐1N.
Synthesis and Physical Chemistry of s‐Tetrazines: Which Ones are Fluorescent and Why?
Authors: Gong Yong‐Hua , Miomandre Fabien , Méallet‐Renault Rachel , Badré Sophie , Galmiche Laurent , Tang Jie , Audebert Pierre , Clavier Gilles 
Published: October 2009

AbstractNew fluorescent tetrazines have been prepared and their electrochemistry and fluorescence efficiency evaluated. The occurrence of fluorescence as well as the wavelength were found to be strongly dependent on the substituents, which have to be electronegative heteroatoms. This has been rationalized through a computational study that showed that the crucial factor is the nature of the HOMO, which determines the existence or not of fluorescence. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2009)
Neural correlates of the spacing effect in explicit verbal semantic encoding support the deficient‐processing theory
Authors: Callan Daniel E. , Schweighofer Nicolas 
Published: October 2009

AbstractSpaced presentations of to‐be‐learned items during encoding leads to superior long‐term retention over massed presentations. Despite over a century of research, the psychological and neural basis of this spacing effect however is still under investigation. To test the hypotheses that the spacing effect results either from reduction in encoding‐related verbal maintenance rehearsal in massed relative to spaced presentations (deficient processing hypothesis) or from greater encoding‐related elaborative rehearsal of relational information in spaced relative to massed presentations (encoding variability hypothesis), we designed a vocabulary learning experiment in which subjects encoded paired‐associates, each composed of a known word paired with a novel word, in both spaced and massed conditions during functional magnetic resonance imaging. As expected, recall performance in delayed cued‐recall tests was significantly better for spaced over massed conditions. Analysis of brain activity during encoding revealed that the left frontal operculum, known to be involved in encoding via verbal maintenance rehearsal, was associated with greater performance‐related increased activity in the spaced relative to massed condition. Consistent with the deficient processing hypothesis, a significant decrease in activity with subsequent episodes of presentation was found in the frontal operculum for the massed but not the spaced condition. Our results suggest that the spacing effect is mediated by activity in the frontal operculum, presumably by encoding‐related increased verbal maintenance rehearsal, which facilitates binding of phonological and word level verbal information for transfer into long‐term memory. Hum Brain Mapp, 2010. © 2009 Wiley‐Liss, Inc.
The neural origin of the priming distance effect: Distance‐dependent recovery of parietal activation using symbolic magnitudes
Authors: Notebaert Karolien , Pesenti Mauro , Reynvoet Bert 
Published: October 2009

AbstractNumerical magnitudes are known to be processed in areas around the intraparietal sulci of the brain. We used an fMRI‐adaptation paradigm to investigate how they are actually coded at the neural level. In a number identification task, we manipulated the numerical distance between prime and target numbers (same, close, and far pairs) and their symbolic notation (Arabic and verbal numerals). We show that bilateral parietal activations present a distance‐dependent recovery of activation positively correlated with the distance between primes and targets: the larger the prime‐target distance, the higher the recovery of activation. Importantly, this effect is only present for trials where an Arabic numeral precedes a verbal numeral and not the reverse. Together, these findings reveal the neural origin of the behavioral priming distance effect and demonstrate that the relative importance of the semantic and nonsemantic pathways in a dual‐route model of number processing is modulated by symbolic notation. Hum Brain Mapp, 2010. © 2009 Wiley‐Liss, Inc.
Glycogen synthase kinases‐3β controls differentiation of malignant glioma cells
Authors: Li Yan , Lu Huimin , Huang Yijun , Xiao Ru , Cai Xiaofeng , He Songmin , Yan Guangmei 
Published: October 2009

AbstractMalignant gliomas persist as a major disease of morbidity and mortality in adult. Differentiation therapy has emerged as a promising candidate modality. However, the mechanism related is unknown. Here, we show that glycogen synthase kinase‐3β (GSK‐3β) is highly expressed and activated during the cholera toxin‐induced differentiation in sensitive C6 and U87‐MG malignant glioma cells, whereas the GSK‐3α activity remains stable. GSK‐3β inhibitors or small interfering RNA suppress the induced‐differentiation in sensitive C6 cells. Conversely, overexpression of a constitutively active form of human GSK‐3β (pcDNA3‐GSK‐3β‐S9A) mutant in resistant U251 glioma cells restores their differentiation capabilities. In addition, GSK‐3β triggers cyclin D1 nuclear export and subsequent degradation, which is necessary for differentiation in C6 and U251 glioma cells. Analysis of human glioma tissues further revealed overexpression of active GSK‐3β. These findings suggest that GSK‐3β is a differentiation fate determinant, and shed new lights on the mechanism by which GSK‐3β regulates cyclin D1 degradation and cellular differentiation in gliomas.