bluuebunny/crossref_metadata_2025_split huggingface dataset:
The impact of dermatological toxicities of anti‐cancer therapy on the dermatological quality of life of cancer patients
Authors: Ra H.S. , Shin S.J. , Kim J.H. , Lim H. , Cho B.C. , Roh M.R. 
Published: February 2012

AbstractBackground  One of the most common side effects of anti‐cancer therapies is treatment‐induced skin changes, referred to as dermatological toxicities. These dermatological toxicities are noteworthy since they have a negative association with quality of life (QoL).Objectives  To evaluate the impact of dermatological toxicities on QoL of cancer patients and to identify the relationship between disease‐related characteristics and QoL and changes in skin protective behaviours following anti‐cancer therapy.Methods  Cancer patients (n = 80: stage II–IV) in a longitudinal prospective study completed a battery of questionnaires at the time of enrolment and after 3 months of anti‐cancer therapy. QoL, skin toxicities, smoking and drinking behaviour, sun‐protective and skin care behaviour assessments were performed before and at 3 months after anti‐cancer therapy. QoL was measured with the Dermatology Life Quality Index (DLQI).Results  A total of 73 patients completed the study. Among them, 48 patients (65.8%) experienced at least grade 1 skin toxicity at 3 months after anti‐cancer therapy. Hair loss, hyperpigmentation and dry skin were the most common dermatological toxicities. The mean baseline DLQI score changed from 1.38 to 3.49 at 3 months after anti‐cancer therapy. Domain 1 (symptoms and feelings, 1.38 points) was the most greatly impacted among patients by anti‐cancer treatment. Patients who experienced at least grade 1 skin toxicity (P = 0.001, 95% CI: 1.939–4.899), employed (P = 0.042, 95% CI: 0.030–1.476), more highly educated (P = 0.030, 95% CI: 0.161–3.132), and diagnosed with gastric cancer (P = 0.001, 95% CI: 2.141–8.250) or renal cell cancer (P = 0.002, 95% CI: 2.731–11.364) showed significantly higher DLQI scores. Patients showed significant change in skin protective behaviour such as use of body moisturizer (P = 0.021) and change in drinking behaviour (P = 0.006) at 3 months following anti‐cancer therapy.Conclusion  Dermatological toxicities due to anti‐cancer therapy affect the QoL of cancer patients. Therefore, health care professionals should pay attention to the psychological effects of skin problems and educate cancer patients to adapt proactive skin protective behaviours to minimize dermatological toxicities of anti‐cancer therapy and maximize QoL.
Short‐ and long‐term outcome of patients with symptoms of spinal cord compression by neuroblastoma
Authors: SIMON THORSTEN , NIEMANN CATHERINA ANNIKA , HERO BARBARA , HENZE GÜNTHER , SUTTORP MEINOLF , SCHILLING FREIMUT H , BERTHOLD FRANK 
Published: February 2012

Aim  Prospective trials on neuroblastoma‐induced myelopathy are lacking. Therefore, we retrospectively analysed patients in four national neuroblastoma trials.Method  Neuroblastoma patients diagnosed between August 1989 and December 2008 were included. Clinical and molecular data were available in the national trials database. Additional details on neurological findings, treatment, and outcome were collected using a questionnaire.Results  Among 2603 patients, 122 (61 males and 61 females) had symptoms of spinal cord compression (SCC), and 99 of these were included in the final long‐term analysis. The survival of patients with symptoms of SCC was better than that of patients without symptoms. Patients first presented with lower extremity motor impairment (95%), impaired cutaneous sensibility (58%), neuropathic pain (56%), bladder dysfunction (44%), and/or constipation (34%). Symptoms improved after first‐line neurosurgery in 36 out of 52 patients and after first line chemotherapy in 30 out of 47 patients (p=0.77). After a median observation time of 8 years 1 month (range 1mo–19y 6mo), 71 out of 99 patients still had residual impairments: motor impairment (43%), scoliosis (31%), impaired bladder function (26%), constipation (19%), impaired cutaneous sensibility (17%), growth delay (14%), and neuropathic pain (5%). The initial treatment had no clear impact on the frequency of late effects.Interpretation  This retrospective analysis showed no clear advantage of either first‐line neurosurgery or chemotherapy and that most patients still exhibit residual symptoms and require specialized care.
Trace element systematics in granulite facies rutile: implications for Zr geothermometry and provenance studies
Authors: KOOIJMAN E. , SMIT M. A. , MEZGER K. , BERNDT J. 
Published: February 2012

AbstractMetamorphic rutile from granulite facies metapelitic rocks of the Archean Pikwitonei Granulite Domain (PGD; Manitoba, Canada) provides constraints on the systematics of trace elements in rutile during high‐temperature conditions and subsequent slow cooling. Compositional profiles and maps of the Zr concentrations in rutile grains (120–600 μm) from three metapelitic gneisses were acquired by electron probe micro‐analysis, using a spatial resolution of down to 2 μm. Simultaneously, profiles were analysed for Nb, Cr and V, which have significantly different diffusion characteristics in rutile. The profiles of all elements show relatively homogeneous concentrations within most grains, but significant inter‐grain differences even within a single thin section. Some rutile grains display a slight concentration decrease from a neighbouring garnet towards the matrix for all measured elements. The lack of diffusion profiles for all analysed elements shows that these are highly immobile in rutile and that distributions of these elements are primary and preserve prograde information. The Nb and Cr concentrations overlap with ranges that are ascribed to different provenances indicating that source discrimination based on these elements is not possible in all cases. High retentiveness for Zr implies that the Zr‐in‐rutile geothermometer is highly robust to diffusive re‐equilibration, even during very slow cooling (<2 °C Ma−1) from granulite facies conditions. Most grains have high Zr contents (3000–4600 ppm). Differences between high Zr contents suggest that during growth under vapour‐absent conditions there may not be saturation of Zr in rutile, even if zircon is present. Therefore, several rutile grains need to be analysed in a sample to obtain a useful minimum peak temperature. The highest Zr concentrations correspond to ∼900 °C. This is significantly higher than previous peak temperature estimates of 820 °C based on two‐feldspar thermometry. On a regional scale this implies that part of the PGD was affected by ultra‐high temperature (UHT) metamorphism. It also implies that rutile is able to preserve primary compositions even to UHT conditions. This study shows that, if combined with textural information, Zr‐in‐rutile has the potential to be a very useful tool for estimating rutile crystallization temperatures and peak metamorphic conditions. For granulite facies rocks, Zr‐in‐rutile yields more reliable peak metamorphic temperatures than most other exchange geothermometers, which tend to partially re‐equilibrate by diffusion during cooling.
Simultaneous Hypertrophic Cardiomyopathy and Muscular Ventricular Septal Defect in an Adult Patient
Authors: Reddy Sahadev T. , Filho Antonio Tito Paladino , Williams Ronald B. , Biederman Robert W.W. 
Published: February 2012

Background: The incidence of muscular ventricular septal defect (VSD) in children is rare, but its prevalence among hypertrophic cardiomyopathy (HCM) patients is surprisingly high. Methods: We present a 24‐year‐old female with HCM associated with muscular VSD without significant symptoms or hemodynamic implications. Conclusion: Cardiac magnetic resonance imaging plays an important role in anatomic and functional noninvasive evaluation of these patients.(Echocardiography 2012;29:E110‐E111)
Carotid–Jugular Fistula Diagnosed by Transesophageal Echocardiography
Authors: Somerville Chris , Lucas Lindsay A. , Biederman Robert W. W. 
Published: February 2012

Arteriovenous fistulas (AVFs) in the neck are rare, and are most frequently caused by internal jugular catheter placement or penetrating trauma. Diagnosis can be missed when pathognomonic physical exam findings are absent, and heart failure can develop late when AVFs go unrepaired. We present what we believe to be the first reported case of common carotid–internal jugular fistula diagnosed during transesophageal echocardiography. Causes, physical exam findings, complications, diagnostic imaging, and treatment are discussed.(Echocardiography 2012;29:E115‐E118)
Complex Ventricular Septal Rupture with Dissection of the Right Ventricular Wall in Ischemic Context
Authors: Pires de Morais Gustavo , Paulo Nelson , Vieira Miguel Silva , Sampaio Francisco , Bettencourt Nuno , Cabral Sofia , Ribeiro José , Fonseca Conceição , Torres Severo , Vouga Luís , Gama Vasco 
Published: February 2012

A 72‐year‐old man was admitted to the local hospital with non‐ST elevation myocardial infarction. In the first 24 hours, a new onset apical murmur was heard. Transthoracic and transesophageal echocardiography showed interventricular septal (IVS) rupture and dissection of the right ventricle (RV) wall forming an echolucent pseudocavity that partially occupied the RV and communicated with the true RV cavity. Multislice computed tomography characterized in detail the IVS and RV wall dissection, and further showed the right coronary artery in the outer border of the RV and pseudocavity, excluding pericardial fluid. Despite surgical correction, progression to cardiogenic shock and death occurred 33 days after admission.(Echocardiography 2012;29:E112‐E114)
Laboratory investigation of triple marking the parasitoid Gonatocerus ashmeadi with a fluorescent dye and two animal proteins
Authors: Irvin N. A. , Hagler J. R. , Hoddle M. S. 
Published: February 2012

AbstractGonatocerus ashmeadi Girault (Hymenoptera: Mymaridae), a parasitoid of Homalodisca vitripennis (Germar) (Hemiptera: Cicadellidae) (glassy‐winged sharpshooter), was used as a model insect to investigate triple marking a minute hymenopteran for potential use for monitoring dispersal patterns of natural enemies in the field. The triple mark contained egg albumin in chicken eggs, casein in bovine milk, and SARDI yellow fluorescent dye. Three application treatments of the triple mark were investigated: (1) a wet topical treatment, (2) a dry residue treatment, and (3) untreated control. The presence of albumin and casein protein marks were detected by an anti‐albumin and anti‐casein enzyme‐linked immunosorbent assays (ELISA) using both ‘soaked’ and ‘crushed’ specimens. Of the topically treated parasitoids, yellow dye, casein, and albumin were detected on 88, 69, and 21% of the crushed samples, respectively. The yellow dye and casein (tested with crush ELISA) were the most efficient marking methods, detecting up to 29% more marked G. ashmeadi. Yellow dye resulted in zero false positives in the untreated control. The percentage of false positives for casein (tested with crush ELISA) was 1.3; however, this was reduced to 0% when a double‐marking system using any two of the three marks (yellow dye, casein, and albumin) were used to mark parasitoids. This double‐mark system resulted in 65% of parasitoids being successfully marked in the topical treatment over the duration of the study. For casein, crush ELISA was 26% more sensitive and 24% more accurate than soak ELISA for detecting this mark. Yellow dye, albumin, and casein (tested with crush ELISA) were retained on marked parasitoids for the entire duration of the 11‐day study. Parasitoids self‐marked with yellow dye, albumin (tested with soak ELISA), casein (tested with crush ELISA), and the double‐mark (tested with crush ELISA) by walking over dried residue of the triple mark. This resulted in up to 17% more marked parasitoids in the residue treatment compared with the untreated control. A topical application of the triple mark had no effect on survival of G. ashmeadi compared with the control. The residue treatment resulted in significantly lower mortality than the untreated control, indicating that G. ashmeadi may have fed on the protein in the residue of the triple‐mark, which enhanced longevity.
Virtual implant planning in the edentulous maxilla: criteria for decision making of prosthesis design
Authors: Avrampou Marianna , Mericske‐Stern Regina , Blatz Markus B. , Katsoulis Joannis 
Published: February 2012

AbstractObjectivesTo evaluate prosthetic parameters in the edentulous anterior maxilla for decision making between fixed and removable implant prosthesis using virtual planning software.Material and methodsCT‐ or DVT‐scans of 43 patients (mean age 62 ± 8 years) with an edentulous maxilla were analyzed with the NobelGuide™ software. Implants (≥3.5 mm diameter, ≥10 mm length) were virtually placed in the optimal three‐dimensional prosthetic position of all maxillary front teeth. Anatomical and prosthetic landmarks, including the cervical crown point (C‐Point), the acrylic flange border (F‐Point), and the implant‐platform buccal‐end (I‐Point) were defined in each middle section to determine four measuring parameters: (1) acrylic flange height (FLHeight), (2) mucosal coverage (MucCov), (3) crown‐Implant distance (CID) and (4) buccal prosthesis profile (ProsthProfile). Based on these parameters, all patients were assigned to one of three classes: (A) MucCov ≤ 0 mm and ProsthProfile≥450 allowing for fixed prosthesis, (B) MucCov = 0–5 mm and/or ProsthProfile = 300–450 probably allowing for fixed prosthesis, and (C) MucCov ≥ 5 mm and/or ProsthProfile ≤ 300 where removable prosthesis is favorable. Statistical analyses included descriptive methods and non‐parametric tests.ResultsMean values were for FLHeight 10.0 mm, MucCov 5.6 mm, CID 7.4 mm, and ProsthProfile 39.10. Seventy percent of patients fulfilled class C criteria (removable), 21% class B (probably fixed), and 2% class A (fixed), while in 7% (three patients) bone volume was insufficient for implant planning.ConclusionsThe proposed classification and virtual planning procedure simplify the decision‐making process regarding type of prosthesis and increase predictability of esthetic treatment outcomes. It was demonstrated that in the majority of cases, the space between the prosthetic crown and implant platform had to be filled with prosthetic materials.
Histological results after maxillary sinus augmentation with Straumann® BoneCeramic, Bio‐Oss®, Puros®, and autologous bone. A randomized controlled clinical trial
Authors: Schmitt Christian Martin , Doering Hendrik , Schmidt Thomas , Lutz Rainer , Neukam Friedrich Wilhelm , Schlegel Karl Andreas 
Published: February 2012

AbstractObjectiveThis investigation focused on a comparison of clinical and histological characteristics after sinus floor augmentation with biphasic calcium phosphate (BCP, Straumann BoneCeramic®), anorganic bovine bone (ABB, Geistlich Bio‐Oss®), mineralized cancellous bone allograft (MCBA, Zimmer Puros®), or autologous bone (AB).Materials and methodsThirty consecutive patients with a posterior edentulous maxillary situation and a vertical bone height less than or equal to 4 mm were included in this study. A two‐stage procedure was carried out. After augmentation of the maxillary sinus with ABB, BCP, MCBA, or AB followed by a healing period of 5 months, biopsies were taken with simultaneous implant placement. The samples were analyzed using microradiography and histology.ResultsNinety‐four implants were placed in the augmented positions and 53 bone biopsies were taken and evaluated. The bone volume fraction of newly formed bone was measured as 30.28 ± 2.16% for BCP, 24.9 ± 5.67% for ABB, 41.74 ± 2.1% for AB, and 35.41 ± 2.78% for MCBA with significant increases in bone volume of AB vs. BCP and ABB, and MCBA vs. ABB samples. Significantly different residual bone substitute material was measured as 15.8 ± 2.1% in the BCP group and 21.36 ± 4.83% in the ABB group.ConclusionAs it provides the highest rate of de novo bone formation, AB can be considered to remain the gold standard in sinus floor augmentation. All tested control materials showed comparable results and are suitable for maxillary sinus augmentation.
Joining in the Dance: Catholic Social Teaching and Ecology
Authors: Deane-Drummond Celia 
Published: February 2012

AbstractThis paper charts the emergence of environmental themes in Roman Catholic Social Teaching (CST). I argue that not only has this strand not been adequately acknowledged, but also that the theological basis for these ideas are rooted in core Roman Catholic teachings on creation, Christology and anthropology. In other words, concern for environmental issues is not an optional extra for Christian practice, but expresses in a fundamental way deep incarnation and human image-bearing as responsible stewardship. I argue that a particular concern with issues of social justice shapes the way environmental problems are addressed, so terms such as human ecology, ecological conversion, solidarity, the common good and world peace all take up ecological threads that are then woven into the account. While Pope John Paul II arguably laid the foundation for the theological bases for these ideas, Pope Benedict XVI applies these ideas more explicitly to current concerns. Yet while the former gave witness to the power of contemplation of the natural world, the latter is more concerned with distortions in philosophical reasoning in the Western world, including dangers he perceived in naturalism and pantheism. Both pontiffs show a lack of specific understanding of ecological systems and tend to idealise both nature in terms of harmonious relationships and humans in terms of mastery.
Oral rehabilitation of severely worn dentition using an overlay for immediate re‐establishment of occlusal vertical dimension
Authors: Freitas Amilcar Chagas , Silva Antônio Materson , Lima Verde Marcus Aurélio Rabelo , Jorge de Aguiar Juliana Ribeiro Pala 
Published: February 2012

doi: 10.1111/j.1741‐2358.2010.00372.xOral rehabilitation of severely worn dentition using an overlay for immediate re‐establishment of occlusal vertical dimensionThe aim of this study was to describe the treatment used in an elderly patient presenting with bruxism and dental erosion, with good gingival health and bone support, but with decreased occlusal vertical dimension (OVD). The oral rehabilitation of elderly patients presenting with bruxism in association with tooth erosion has been a great challenge for dentists. The loss of OVD, the presence of occlusal instability and the absence of an effective anterior guide due excessive dental wear, can damage stomatognathic system (SS) biology, the function and the aesthetics. In the first treatment stage, an overlay removable partial denture (ORPD) was fabricated for the immediate re‐establishment of function and aesthetics. After a 2‐month follow up, with the patient presenting no symptoms, a second rehabilitation stage was accomplished, with fixed and removable prostheses. Oral rehabilitation with an ORPD was able to re‐establish the SS biology, but a correct diagnosis and treatment plan are essential for success. The ORPD is a non‐invasive and reversible restoring modality for general dentists that allow the re‐establishment of the patient’s immediate aesthetics and function at low cost.
Last three days of life in the hospital: a comparison of symptoms, signs and treatments in the young old and the oldest old patients using the Resident Assessment Instrument for Palliative Care
Authors: Steindal Simen A. , Ranhoff Anette H. , Bredal Inger S. , Sørbye Liv W. , Lerdal Anners 
Published: February 2012

Background.  Knowledge concerning the provision of end of life care to the oldest old hospitalised patients is deficient.Aims and objectives.  To analyse whether there were differences in registered nurses’ documentation of the young old vs. the oldest old patients according to symptoms, clinical signs and treatment in the last 3 days of life.Design.  Data were collected retrospectively in a cross‐sectional comparative study at a hospital between autumn 2007 and spring 2009.Methods.  The study included 190 patients: 101 (65–84 years) and 89 (85+). Data were extracted from the patients’ electronic records using the Resident Assessment Instrument for Palliative Care (RAI‐PC).Results.  Falls (OR = 4.01, 95% CI 1.47–10.90) and peripheral oedema (OR = 2.74, 95% CI 1.06–7.11) were significantly more frequent documented in the oldest old patients compared with the young old patients. Delirium was recorded in 15.3% of all patients.Conclusion.  With the exception of more falls and peripheral oedema in the oldest old patients, this study showed no differences in symptoms and treatment between the young old and the oldest old patients. Delirium was poorly documented compared to other studies.Implications for practice.  The oldest old patients have a higher risk of falls in the final phase of life, and fall prevention should be considered.
Cumulative incidence of pandemic influenza A (H1N1) 2009 by a community‐based serological cohort study in Selenghe Province, Mongolia
Authors: Burmaa Alexanderyn , Tsatsral Sosorbaramyn , Odagiri Takashi , Suzuki Akira , Oshitani Hitoshi , Nymadawa Pagbajabyn 
Published: February 2012

Please cite this paper as: Burmaa et al. (2012) Cumulative incidence of pandemic influenza A (H1N1) 2009 by a community‐based serological cohort study in Selenghe Province, Mongolia. Influenza and Other Respiratory Viruses 6(601), e97–e104.Background  Large community outbreaks of pandemic A (H1N1) 2009 occurred between October and December 2009 in Mongolia. A serological study was conducted among the general population by testing paired sera collected before and after the first wave of pandemic in Selenghe province, Mongolia. None of the study participants had been vaccinated for pandemic A (H1N1) 2009 before the second samples were collected.Objective  The objective of this study was to estimate cumulative incidence of pandemic A (H1N1) 2009 in different age‐groups of Selenghe province residents.Methods  After informed consent was obtained from apparently healthy volunteers, the paired sera and background information were collected. Antibody titers were measured using hemagglutinin inhibition (HI) and microneutralization (MN) assays for A/California/07/2009pdm. A fourfold rise in antibody titers was regarded as the evidence of infection.Results  The overall cumulative incidences in the study group for all ages were 28·8% (76/264) by HI, 35·2% (93/264) by MN, and 25·0% (66/264) by both HI and MN. Cumulative incidences of infection varied among age‐groups, with children aged 2–4 and 5–9 years having high cumulative incidence of infection. Overall cumulative incidences of infection in the whole population were estimated to be 23·0% (4946/21 460) by HI, 30·2% (6473/21 460) by MN, and 18·8% (4036/21 460) by both HI and MN.Conclusions  This study indicates that about one‐fourth of the total population in Selenghe province was infected with pandemic A (H1N1) 2009 virus during the first wave of the pandemic.