bluuebunny/crossref_metadata_2025_split huggingface dataset:
Drosophila Translational Elongation Factor-1γ Is Modified in Response to DOA Kinase Activity and Is Essential for Cellular Viability
Authors: Fan Yujie , Schlierf Michael , Gaspar Ana Cuervo , Dreux Catherine , Kpebe Arlette , Chaney Linda , Mathieu Aurelie , Hitte Christophe , Grémy Olivier , Sarot Emeline , Horn Mark , Zhao Yunlong , Kinzy Terri Goss , Rabinow Leonard 
Published: October 2009

Abstract
Drosophila translational elongation factor-1γ (EF1γ) interacts in the yeast two-hybrid system with DOA, the LAMMER protein kinase of Drosophila. Analysis of mutant EF1γ alleles reveals that the locus encodes a structurally conserved protein essential for both organismal and cellular survival. Although no genetic interactions were detected in combinations with mutations in EF1α, an EF1γ allele enhanced mutant phenotypes of Doa alleles. A predicted LAMMER kinase phosphorylation site conserved near the C terminus of all EF1γ orthologs is a phosphorylation site in vitro for both Drosophila DOA and tobacco PK12 LAMMER kinases. EF1γ protein derived from Doa mutant flies migrates with altered mobility on SDS gels, consistent with it being an in vivo substrate of DOA kinase. However, the aberrant mobility appears to be due to a secondary protein modification, since the mobility of EF1γ protein obtained from wild-type Drosophila is unaltered following treatment with several nonspecific phosphatases. Expression of a construct expressing a serine-to-alanine substitution in the LAMMER kinase phosphorylation site into the fly germline rescued null EF1γ alleles but at reduced efficiency compared to a wild-type construct. Our data suggest that EF1γ functions in vital cellular processes in addition to translational elongation and is a LAMMER kinase substrate in vivo.
Recovery of Cognitive Performance and Fatigue after One Night of Sleep Deprivation
Authors: Ikegami Kazunori , Ogyu Seizo , Arakomo Yuko , Suzuki Kiyomi , Mafune Kosuke , Hiro Hisanori , Nagata Shoji 
Published: October 2009

Recovery of Cognitive Performance and Fatigue after One Night of Sleep Deprivation: Kazunori Ikegami, et al. Department of Mental Health, Institute of Industrial Ecological Sciences, University of Occupational and Environmental Health, JapanObjectivesThe aim of this study was to investigate how subjective sleepiness, mood states, simple and high‐order cognitive performance change after one night of sleep deprivation (SD) and recover to after 7 h normal recovery sleep opportunity during three recovery days.MethodsTen healthy subjects participated in this study. We measured their subjective sleepiness, mood states and their performances of 2 simple tasks and 4 high‐order cognitive tasks twice a day for 5 days, on the baseline day, post‐vigil day and 3 recovery days after SD. This study was conducted considering each participant's motivation for task, learning effect and diurnal variation of performance.ResultsThe performances of simple tasks such as addition or short‐term memory were not reduced after SD and were the poorest on the baseline day, and improved gradually; however the high‐order cognitive performances were at their lowest on the post‐vigil day and needed 2 recovery sleep opportunities to return to the baseline level. Fatigue and confusion in mood states and subjective sleepiness were also at their lowest after SD. Subjective sleepiness nearly recovered to the baseline level on the 1st recovery day, but fatigue and confusion reached the baseline levels on the 2nd recovery day.ConclusionThese results suggest that cognitive deterioration and the recovery process may differ between simple task performance and high‐order cognitive task performance, which needed 2 ordinary sleep opportunities to recover to the baseline level, and the change of subjective mood states were also different for each mood.
Inhaled Fluorescent Magnetic Nanoparticles Induced Extramedullary Hematopoiesis in the Spleen of Mice
Authors: Kwon Jung‐Taek , Kim Dae‐Seong , Minai‐Tehrani Arash , Hwang Soon‐Kyung , Chang Seung‐Hee , Lee Eun‐Sun , Xu Cheng‐Xiong , Lim Hwang Tae , Kim Ji‐Eun , Yoon Byung‐Il , An Gil‐Hwan , Lee Kee‐Ho , Lee Jin‐Kyu , Cho Myung‐Haing 
Published: October 2009

Inhaled Fluorescent Magnetic Nanoparticles Induced Extramedullary Hematopoiesis in the Spleen of Mice: Jung‐Taek Kwon, et al. Laboratory of Toxicology, College of Veterinary Medicine, Seoul National University, KoreaObjectivesNanomaterials are used in a wide variety of industrial materials such as semiconductors, magnetic resonance imaging, gene delivery carriers for gene therapy and many others; thus, human seems to be frequently exposed to them. Such diverse applications of nanoparticles elicit the need to identify the positive aspects of nanomaterials while avoiding the potential toxic effects. In this study, inhalation toxicity of manufactured nanomaterials using fluorescent magnetic nanoparticles (FMNPs) was assessed to address the issue of potential nanoparticle toxicity.MethodsBiological samples from a previous mouse FMNP exposure experiment were analyzed for potential FMNP toxicity. Mice inhaled FMNPs for 4 wk through a nose‐only exposure chamber developed by our group for 4 wk and the potential toxicity of FMNPs was analyzed.ResultsThe nanoparticle distribution by scanning mobility particle sizer (SMPS) analysis showed that the mean values of number concentration (mass concentrations) in the nose‐only exposure chamber were maintained at 4.89×105/cm3(approximately 159.4 µg/m3) for the low concentration and 9.34×105/cm3(approximately 319.5 µg/m3) for the high concentration, respectively. Inhalation of FMNPs caused a decrease of body weight and significant changes of white blood cells (WBCs) levels in whole blood. The FMNPs induced extramedullary hematopoiesis in the spleen without having a pulmonary effect.ConclusionsOur results support the proposition that extensive toxicity evaluation is needed for practical applications of anthropogenic nanomaterials and suggest that careful regulation of nanoparticle applications may be necessary to maintain a high quality of life as well as for facilitating the development of nanotechnology.
Occupational Stress and Burnout of Lawyers
Authors: Tsai Feng‐Jen , Huang Wei‐Lun , Chan Chang‐Chuan 
Published: October 2009

Occupational Stress and Burnout of Lawyers: Feng‐Jen Tsai, et al. Institute of Occupational Medicine and Industrial Hygiene, College of Public Health, National Taiwan University, TaiwanObjectiveThe aim of this study was to explore the associations between burnout and occupational stress measured by demand‐control support (DCS) and effort‐reward imbalance (ERI) models among lawyers.MethodsThis cross‐sectional study included 180 lawyers from 26 law firms in the Taipei Bar. The Chinese version of Karasek's job content questionnaire (C‐JCQ) and the Chinese version of Siegrist's ERI questionnaire (C‐ERI) were used to measure occupational stress, and the Chinese version of the Copenhagen Burnout Inventory (C‐CBI) questionnaire was used to measure personal, work‐related and client‐related burnout. Logistic regression analysis was used to determine the associations between burnout and lawyers' occupational stress and job specialty adjusting for age, gender, marital status, work experience, working hours per day, firm size and the significant occupational stress of each model for the other.ResultsLawyers reported relatively higher scores in job control, psychological demands and effort, and high prevalence of self‐perceived work stress. Litigious lawyers had higher decision authority and workplace social support, higher work‐related burnout and higher client‐related burnout than non‐litigious lawyers. Personal burnout and work‐related burnout were associated with high psychological demands, effort, and effort‐reward ratio.ConclusionsHigh occupational stress was associated with high levels of personal and work‐related burnout among lawyers.
Short Nighttime Sleep-Duration and Hyperactivity Trajectories in Early Childhood
Authors: Touchette Evelyne , Côté Sylvana M. , Petit Dominique , Liu Xuecheng , Boivin Michel , Falissard Bruno , Tremblay Richard E. , Montplaisir Jacques Y. 
Published: October 2009

OBJECTIVES: Our objectives were to investigate the developmental trajectories of nighttime sleep duration and hyperactivity over the preschool years and to identify the risk factors associated with short nighttime sleep duration and high hyperactivity scores.
DESIGN, SETTING, AND PARTICIPANTS: Nighttime sleep duration and hyperactivity were measured yearly by questionnaires administered to mothers of 2057 children from age 1.5 to 5 years. Developmental trajectories of nighttime sleep duration and hyperactivity throughout early childhood were analyzed to determine interassociations. A multinomial logistic regression was performed to determine which factors among selected child, maternal, and family characteristics and parental practices surrounding sleep periods in early childhood were associated with short nighttime sleep duration and high hyperactivity scores.
RESULTS: The trajectories of nighttime sleep duration and hyperactivity were significantly associated. The odds ratio (OR) of reporting short nighttime sleep duration was 5.1 for highly hyperactive children (confidence interval [CI]: 3.2–7.9), whereas the OR of reporting high hyperactivity scores was 4.2 for persistently short sleepers (CI: 2.7–6.6). The risk factors for reporting short nighttime sleep duration and high hyperactivity scores were (1) being a boy, (2) having insufficient household income, (3) having a mother with a low education, and (4) being comforted outside the bed after a nocturnal awakening at 1.5 years of age.
CONCLUSIONS: The risk of short nighttime sleep duration in highly hyperactive children is greater than the risk of high hyperactivity scores in short sleepers. Preventive interventions that target boys living in adverse familial conditions could be used to address these concomitant behavioral problems.
Acute Heart Failure Syndromes in the Pediatric Emergency Department
Authors: Macicek Scott M. , Macias Charles G. , Jefferies John L. , Kim Jeffrey J. , Price Jack F. 
Published: October 2009

OBJECTIVE: The objectives of this study were to (1) describe the clinical presentation of acute heart failure syndromes (AHFS) in the pediatric emergency department (ED) and (2) determine the physician treatment regimens and outcomes in the same population.
METHODS: This was a cross-sectional study of patients who presented with AHFS to the ED at our institution from January 2003 to October 2006. We defined AHFS as “the gradual or rapid deterioration in heart failure signs and symptoms resulting in a need for urgent therapy.” Patients were included when they had documented signs or symptoms of HF attributable to ventricular dysfunction. Patients were excluded when they were older than 21 years or had HF symptoms that were attributable to left-to-right intracardiac shunting or left-sided obstructive lesions. All eligible ED patient visits were adjudicated by a pediatric HF specialist.
RESULTS: Fifty-seven patient visits to the ED met inclusion criteria. There was a significant difference in time from arrival to treatment with a diuretic when the therapy was started in the ED rather than in the inpatient units. Median time to initiation of a vasoactive agent was significantly less for patients whose infusions were started in the ED compared with the ICU. Two patients died in the ED, and overall mortality or need for mechanical circulatory support for hospitalized patients was 18% (n = 10).
CONCLUSIONS: These data yield important insight into the clinical features and initial treatment of children who present with AHFS in the ED and may allow for improved recognition and treatment of this clinical syndrome.
Exploring the Relationship Among Weight, Race, and Sexual Behaviors Among Girls
Authors: Akers Aletha Yvette , Lynch Cheryl P. , Gold Melanie A. , Chang Judy Chia-Chi , Doswell Willa , Wiesenfeld Harold C. , Feng Wentao , Bost James 
Published: October 2009

OBJECTIVE: The relationship between weight and sexual behavior among adolescents is poorly understood. We examined this relationship in a nationally representative sample of high school girls.
METHODS: We performed a cross-sectional analysis of self-reported data from 7193 high school girls who completed the 2005 Youth Risk Behavior Surveillance survey. We used multivariate logistic regression to examine associations among 3 weight indices (BMI calculated from self-reported weight and height, perceived weight, and weight misperception) and 6 sexual behaviors (ever had vaginal sex; sex before age 13; ≥4 sexual partners; and alcohol, condom, and oral contraceptive use at last sex) adjusting for age, race/ethnicity, and a history of intimate partner violence.
RESULTS: There were no differences in the likelihood of ever having sex on the basis of BMI or weight perception accuracy; however, girls who perceived themselves as overweight were less likely to have ever had sex. Among sexually active girls, those who had low BMI and perceived themselves as overweight or had overweight misperceptions were less likely to report condom use at last sex. Sexually active girls who perceived themselves as overweight were also more likely to have had sex before age 13. Associations between the 3 weight indices and sexual risk behaviors varied across racial/ethnic groups.
CONCLUSIONS: Sexual risk behaviors may be more common among girls who are underweight or perceive themselves (accurately or not) to be overweight and vary by racial/ethnic group. This suggests that girls at weight extremes and those from different racial backgrounds may have unique sexual health education and prevention needs.
Economic Evaluation of Inhaled Nitric Oxide in Preterm Infants Undergoing Mechanical Ventilation
Authors: Zupancic John A. F. , Hibbs Anna Maria , Palermo Lisa , Truog William E. , Cnaan Avital , Black Dennis M. , Ballard Philip L. , Wadlinger Sandra R. , Ballard Roberta A. ,   and the NO CLD Trial Group
Published: October 2009

OBJECTIVE: In the previously reported Nitric Oxide for Chronic Lung Disease (NO CLD) trial, ventilated preterm infants who received a course of inhaled nitric oxide (iNO) between 7 and 21 days of life had a significant improvement in survival without bronchopulmonary dysplasia (BPD), as well as a shorter duration of admission and ventilation. However, the price for the drug may be a barrier to widespread use. We sought to estimate the incremental cost-effectiveness of iNO therapy to prevent BPD in infants of &lt;1250 g birth weight.
METHODS: We used patient-level data from the NO CLD randomized trial. The study took a third-party payer perspective and measured costs and effects through hospital discharge. We applied previously reported hospital per-diem costs stratified according to intensity of ventilatory support, nitric oxide costs from standard market prices, and professional (physician) fees from the Medicare fee schedule. We compared log transformed costs by using multivariable modeling and performed incremental cost-effectiveness analysis with estimation of uncertainty through nonparametric bootstrapping.
RESULTS: The mean cost per infant was $193125 in the placebo group and $194702 in the iNO group (adjusted P = .17). The point estimate for the incremental cost per additional survivor without BPD was $21297. For infants in whom iNO was initiated between 7 and 14 days of life, the mean cost per infant was $187407 in the placebo group and $181525 in the iNO group (adjusted P = .46). In this group of early treated infants, there was a 71% probability that iNO actually decreased costs while improving outcomes.
CONCLUSIONS: Despite its higher price relative to many other neonatal therapies, iNO in this trial was not associated with higher costs of care, an effect that is likely due to its impact on length of stay and ventilation. Indeed, for infants who receive nitric oxide between 7 and 14 days of life, the therapy seemed to lower costs while improving outcomes.
Prospective, Observational Study of Outcomes in Neonates With Severe Thrombocytopenia
Authors: Stanworth Simon J. , Clarke Paul , Watts Tim , Ballard Sally , Choo Louise , Morris Tim , Murphy Mike F. , Roberts Irene ,   for the Platelets and Neonatal Transfusion Study Group
Published: October 2009

OBJECTIVE: A cross-sectional, observational study of outcomes for neonates with severe neonatal thrombocytopenia (SNT; platelet count of &lt;60 × 109 platelets per L) was performed to examine hemorrhage and use of platelet transfusions.
METHODS: Neonates who were admitted to 7 NICUs and developed SNT were enrolled for daily data collection.
RESULTS: Among 3652 neonatal admissions, 194 neonates (5%) developed SNT. The median gestational age of 169 enrolled neonates was 27 weeks (interquartile range [IQR]: 24–32 weeks), and the median birth weight was 822 g (IQR: 670–1300 g). Platelet count nadirs were &lt;20 × 109, 20 to 39 × 109, and 40 to 59 × 109 platelets per L for 58 (34%), 64 (39%), and 47 (28%) of all enrolled infants, respectively. During the study, 31 infants (18%) had no recorded hemorrhage, 123 (73%) developed minor hemorrhage, and 15 (9%) developed major hemorrhage. Thirteen (87%) of 15 episodes of major hemorrhage occurred in neonates with gestational ages of &lt;28 weeks. Platelet transfusions (n = 415) were administered to 116 infants (69%); for 338 (81%) transfusions, the main recorded reason was low platelet count. Transfusions increased the platelet count from a median of 27 × 109 platelets per L (IQR: 19–36 × 109 platelets per L) to 79 × 109 platelets per L (IQR: 47.5–127 × 109 platelets per L).
CONCLUSIONS: Although one third of neonates enrolled in this study developed thrombocytopenia of &lt;20 × 109 platelets per L, 91% did not develop major hemorrhage. Most platelet transfusions were given to neonates with thrombocytopenia with no bleeding or minor bleeding only.
Impact of Music, Music Lyrics, and Music Videos on Children and Youth
Authors:   Council on Communications and Media
Published: October 2009

This Policy Statement was retired July 2017.
Music plays an important role in the socialization of children and adolescents. Popular music is present almost everywhere, and it is easily available through the radio, various recordings, the Internet, and new technologies, allowing adolescents to hear it in diverse settings and situations, alone or shared with friends. Parents often are unaware of the lyrics to which their children are listening because of the increasing use of downloaded music and headphones. Research on popular music has explored its effects on schoolwork, social interactions, mood and affect, and particularly behavior. The effect that popular music has on children's and adolescents' behavior and emotions is of paramount concern. Lyrics have become more explicit in their references to drugs, sex, and violence over the years, particularly in certain genres. A teenager's preference for certain types of music could be correlated or associated with certain behaviors. As with popular music, the perception and the effect of music-video messages are important, because research has reported that exposure to violence, sexual messages, sexual stereotypes, and use of substances of abuse in music videos might produce significant changes in behaviors and attitudes of young viewers. Pediatricians and parents should be aware of this information. Furthermore, with the evidence portrayed in these studies, it is essential for pediatricians and parents to take a stand regarding music lyrics.
Les Mesures De Cisaillement Dans Les Laboratoires Français
Authors: Mayer A. 
Published: October 2009

Synopsis Dans cet exposé, l'auteur rappelle rapidement les méthodes de mesure du cisaillement appliquees dans les laboratoires français. I1 passe ensuite à la description des essais faits à I'occasion de la conférence de Londres pour préciser les facteurs qui influent sur le cisaillement. I1 souligne la différence entre essais rapides et essais lents, rappelle la relation entre la pression de consolidation et la cohésion des matériaux reconstitués, et indique que la tension superkielle du liquide interstitiel n'influe pratiquement pas sur la cohésion. I1 donne enfin connaissance d'un dispositif experimental qui a permis, à I'appareil triaxial, d'inverser l'ordre de grandeur des pressions verticale et transversale. Ce dispositif a permis de faire des essais de cisaille- ment pur et de prolonger la courbe intrins&que jusqu'à I'axe des Z et au-delà de celle-ci. Jusqu'ici les essais n'ont porté que sur l'argile plastique de la région parisienne. D'autres essais suivront, notamment sur des limons, dont les résultats seront publiés ultérieurement. The methods used in French Laboratories for the measurement of shear strength are briefly outlined. Tests carried out on the occasion of the London conference in order to specify the factors which affect shear strength are described. The difference between rapid and slow tests, and the relationship between the consolidation pressure and the cohesion of reconstituted materials are dis- cussed. The Author indicates that the surface pressure of the interstitial liquid has no practical intluence on the cohesion. An experimental device by means of which it is possible, in the triaxial apparatus, to invert the range of the vertical and transverse pressures is described. This device has enabled tests of the true shear strength to be carried out, and has made it possible to extend the intrinsic curve up to the Z-axis and beyond. Up to now tests have been carried out only on plastic clay from the Paris region. Other tests will follow, notably on silts, the results of which will be published later.
Foundations at Poole Power Station
Authors: Megaw T. M. 
Published: October 2009

Synopsis Poole power station is sited on tidal mudlands, where stiff clays an; overlain by soft silty clay 10 to 40 feet thick, quite inadequate to carry any heavy loads. Foundations were either excavated within a steel sheet piled cofferdam, down to stiff clay, or were carried on bearing piles. Access for construction plant was obtained by forming a 5-foot thick chalk crust over a large part of the site. Measurements were made of pressures from the soft clay, by recording the shortening of steel struts in cofferdams within which the coal wharf was constructed. These are compared with loads calculated from the measured shear strength and cohesion of the soft clay. The Author concludes that the equilibrium shear strength of the clay is a more accurate basis for calculation than is the immediate shear strength. La centrale electrique de Poole est situé sur un terrain formé par des dépôts de vase amenés par la marée, où les argiles fermes sont recouvertes d'argile alluvionnaire molle variant en épaisseur de 3 à 12 mètres, ne convenant absolument pas pour supporter de fortes charges. Les fondations furent effectuées soit en faisant des excavations à l'intérieur de coffrages en palplanches descendant jusqu'à l'argile ferme, soit sur pilotis. L'accèsaux travaux de construction fut rendu possible par la formation d'une croûte de calcaire de 1,50 m. d'épaisseur sur la plus grande partie du site. Les pressions de l'argile molle furent mesurées en enregistrant le raccourcissement des entretoises d'acier dans les coffrages à l'intérieur desquels fut construit la soute à charbon. Ces pressions sont comparées avec les charges calculées d'après la force de cisaillement mesurée et la cohésion de l'argile molle. L'auteur conclut que la force de cisaillement de l'argile en état d'équilibre constitue une base de calcul plus précise que ne l'est la force de cisaillement immédiate.