bluuebunny/crossref_metadata_2025_split huggingface dataset:
TCL1: a shared tumor-associated antigen for immunotherapy against B-cell lymphomas
Authors: Weng Jinsheng , Rawal Seema , Chu Fuliang , Park Hyun Jun , Sharma Rakesh , Delgado David A. , Fayad Luis , Fanale Michelle , Romaguera Jorge , Luong Amber , Kwak Larry W. , Neelapu Sattva S. 
Published: May 2012

Abstract
Immunotherapy with therapeutic idiotype vaccines offers promise for treatment of B-cell malignancies. However, identification of novel immunogenic lymphoma-associated antigens that are universally expressed is necessary to overcome the barriers of patient-specific idiotype vaccines. Here, we determined whether T-cell leukemia/lymphoma 1 (TCL1) oncoprotein encoded by the TCL1 gene could be a target for immunotherapy of B-cell malignancies. We show that TCL1 mRNA and protein are selectively expressed in normal B cells but markedly hyperexpressed in multiple human B-cell lymphomas, including follicular lymphoma, chronic lymphocytic leukemia, mantle cell lymphoma, diffuse large B-cell lymphoma, and splenic marginal zone B-cell lymphoma. We demonstrated that TCL1-specific CD8+ T cells can be generated from HLA-A*0201 (HLA-A2)+ normal donors and identified TCL171-78 (LLPIMWQL) as the minimal epitope recognized by these T cells. More importantly, TCL171-78 peptide-specific T cells were present in the peripheral blood and tumor-infiltrating lymphocytes of lymphoma patients, could be expanded in vitro, and lysed autologous tumor cells but not normal B cells in an HLA-A2–restricted manner. Our results suggest that TCL1 is naturally processed and presented on the surface of lymphoma cells for recognition by cytotoxic T cells and can serve as a novel target for development of immunotherapeutic strategies against common B-cell lymphomas.
A Prospective Study of Bisphosphonate Use and Risk of Colorectal Cancer
Authors: Khalili Hamed , Huang Edward S. , Ogino Shuji , Fuchs Charles S. , Chan Andrew T. 
Published: May 2012

Purpose Bisphosphonates are used for the treatment of bone metastases and have been associated with a lower risk of breast cancer. A recent case-control study showed an inverse association between bisphosphonate use and colorectal cancer. Data from prospective cohorts are lacking. Patients and Methods We prospectively examined the relationship between bisphosphonate use and risk of colorectal cancer among 86,277 women enrolled onto the Nurses Health Study (NHS). Since 1998, participants have returned biennial questionnaires in which they were specifically queried about the regular use of bisphosphonates. We used Cox proportional hazards models to calculate hazard ratios (HRs) and 95% CIs for risk of colorectal cancer. Results Through 2008, we documented 801 cases of colorectal cancer over 814,406 person-years of follow-up. The age-adjusted HR for women who regularly used bisphosphonates was 0.92 (95% CI, 0.73 to 1.14) and was further attenuated after adjustment for other risk factors (multivariate HR, 1.04; 95% CI, 0.82 to 1.33). The risk was not influenced by duration of use (Ptrend = 0.79). Compared with nonusers, the multivariate-adjusted HRs of colorectal cancer were 1.24 (95% CI, 0.94 to 1.64) for women with 1 to 2 years of use, 1.16 (95% CI, 0.79 to 1.69) for 3 to 4 years of use, and 0.97 (95% CI, 0.60 to 1.56) for ≥ 5 years of use. There was no association between bisphosphonate use and colorectal cancer within strata of other risk factors. Conclusion In a large prospective cohort, we did not observe an association between long-term use of bisphosphonates and risk of colorectal cancer.
Long-Term Results of CCG 5942: A Randomized Comparison of Chemotherapy With and Without Radiotherapy for Children With Hodgkin's Lymphoma—A Report From the Children's Oncology Group
Authors: Wolden Suzanne L. , Chen Lu , Kelly Kara M. , Herzog Philip , Gilchrist Gerald S. , Thomson John , Sposto Richard , Kadin Marshall E. , Hutchinson Raymond J. , Nachman James 
Published: May 2012

Purpose In 1995, the Children's Cancer Group (CCG) opened a trial for patients with Hodgkin's lymphoma evaluating whether low-dose involved-field radiation therapy (IFRT) improved event-free survival (EFS) for patients achieving a complete response after chemotherapy. We present the long-term study outcome using final data through March 2007. Patients and Methods Between January 1995 and December 1998, 826 eligible patients were enrolled onto CCG 5942. Four hundred ninety-eight patients achieving an initial complete response to chemotherapy were randomly assigned to receive IFRT or no further therapy. EFS and overall survival (OS) were assessed from the date of study entry or random assignment, as appropriate. Results Ten-year EFS and OS rates for the entire cohort were 83.5% and 92.5%, respectively. In an as-treated analysis for randomly assigned patients, the 10-year EFS and OS rates were 91.2% and 97.1%, respectively, for IFRT and 82.9% and 95.9%, respectively, for no further therapy. For EFS and OS comparisons, P = .004 and P = .50, respectively. Bulk disease, “B” symptoms, and nodular sclerosis histology were risk factors for inferior EFS. Conclusion With a median follow-up of 7.7 years, IFRT produced a statistically significant improvement in EFS but no improvement in OS. For individual patients, the relative risks of relapse versus late effects of IFRT must be considered. Patient and disease characteristics and early response assessment will aid in deciding which patients are most likely to benefit from IFRT.
Synthesis and Properties of Anthrylene-Substituted Phenyleneethynylene Dyes Having Amino/Cyano Group(s) and Their Application to Dye-Sensitized Solar Cells
Authors: Yang Xin , Kajiyama Shingo , Fang Jing-Kun , Xu Feng , Uemura Yu , Koumura Nagatoshi , Hara Kohjiro , Orita Akihiro , Otera Junzo 
Published: May 2012

Abstract
A series of anthrylene-substituted phenyleneethynylene dyes having amino/cyano group(s) were prepared by repeating Sonogashira coupling between aryl halides and terminal acetylenes. In UV–vis absorption spectra, the 9,10-anthrylene-substituted dyes showed a strong absorption band of which λmax was located from 502 to 521 nm and ε was more than 5.2 × 104 L mol−1 cm−1 indicating a highly expanded π-system in comparison with 1,5-anthrylene dye (λmax = 431 nm, ε = 2.6 × 104 L mol−1 cm−1). Lippert–Mataga plots demonstrated that the amino- and cyano-substituted dyes underwent larger charge separation in the excited states. These acetylenic dyes served as sensitizers of dye-sensitized solar cell to achieve 5.0% of photo-to-current energy conversion efficiency.
Synthesis of Peptide-Based Cyclophane Oligomers Having Multivalently Enhanced Guest-Binding Affinity
Authors: Hayashida Osamu , Nakashima Tomomi 
Published: May 2012

Abstract
Water-soluble cyclophane dimer, trimer, tetramer, and pentamer were prepared by aminolysis of succinimidyl ester derivative of tetraaza[6.1.6.1]paracyclophane with lysine and the corresponding lysine peptide as a scaffold, followed by removal of the protecting groups. The present cyclophane oligomers showed enhanced guest-binding affinities toward fluorescent guests such as 6-p-toluidinonaphthalene-2-sulfonate, in comparison with those of monocyclic cyclophane, reflecting multivalency effects in macrocycles. The effects of multivalent macrocycles on the guest-binding of the present cyclophane oligomers were also confirmed by surface plasmon resonance (SPR) measurements.
On the Complexity of Chooser–Picker Positional Games
Authors: Csernenszky András , Martin Ryan R. , Pluhár András 
Published: May 2012

Abstract.Two new versions of the so-called Maker–Breaker Positional Games are defined by József Beck. He defines two players, Picker and Chooser. In each round, Picker takes a pair of elements not already selected and Chooser keeps one and returns the other to Picker. In the Picker–Chooser version Picker plays as Maker and Chooser plays as Breaker, while the roles are swapped in the Chooser–Picker version. The outcome of these games is sometimes very similar to that of the traditional Maker–Breaker games. Here we show that both Picker–Chooser and Chooser–Picker games are NP-hard, which gives support to the paradigm that the games behave similarly while being quite different in definition. We also investigate the pairing strategies for Maker–Breaker games, and apply these results to the game called “Snaky”.
Short-term effects of GH treatment on coagulation, fibrinolysis, inflammation biomarkers, and insulin resistance status in prepubertal children with GH deficiency
Authors: Cañete Ramón , Valle Miguel , Martos Rosario , Sánchez-Carrión Adela , Cañete María Dolores , van Donkelaar Eva L 
Published: May 2012

ObjectiveThe aims of this study was to determine whether prepubertal GH deficiency (GHD) children showed any impairment in coagulation- and fibrinolysis-related parameters and in inflammatory and insulin resistance markers and to evaluate the effect of short-term GH therapy on these parameters.DesignThis was a 6-month, prospective, observational, case–control study (36 prepubertal children with GHD and 38 healthy prepubertal children with no differences in BMI). Comparison of study parameter values in GHD and control groups at baseline and after 6 months of GH treatment in the GHD group. The following were analyzed: glucose, insulin, fibrinogen, absolute plasminogen activator inhibitor type 1 (aPAI-1), von Willebrand factor (vWF), homeostasis model assessment for insulin resistance (HOMA-IR) index, C-reactive protein (CRP), and interleukin 6 (IL6) levels.ResultsChildren with GHD showed higher baseline levels of aPAI-1 and fibrinogen and lower levels of glucose, insulin, and HOMA-IR index than healthy controls. No intergroup differences were found for vWF. After 6 months of treatment, aPAI-1 levels were lower but no changes were observed in fibrinogen or vWF levels, which were similar to those of controls. Glucose levels increased, though not significantly, while insulin levels and HOMA-IR index rose to normal levels. A positive correlation was found between changes in insulin status/HOMA-IR index and levels of aPAI-1, fibrinogen, vWF, CRP, and IL6.ConclusionsAt early ages, GH therapy appears to exert beneficial effects on the amount of aPAI-1. At the same time, it increases the state of insulin resistance (HOMA-IR index) without modifying the levels of fibrinogen, vWF, CRP, and IL6.
Upregulation of Calprotectin and Downregulation of Retinol Binding Protein in the Serum of Workers with Trichloroethylene‐induced Hypersensitivity Dermatitis
Authors: Huang Zhenlie , Yue Fei , Yang Xingfen , Xia Lihua , Chen Cishan , Qiu Xinxiang , Huang Jianxun , Li Laiyu , Kamijima Michihiro , Nakajima Tamie , Huang Hanlin 
Published: May 2012

Upregulation of Calprotectin and Down‐regulation of Retinol Binding Protein in the Serum of Workers with Trichloroethylene‐induced Hyper‐sensitivity Dermatitis: Zhenlie HUANG, et al. Guangdong Prevention and Treatment Center for Occupational Diseases, China—ObjectivesThe aim of this study was to explore the involved pathophysiological processes and develop biomarkers of trichloroethylene‐induced hypersensitivity dermatitis (THD).MethodsWe examined the impact of THD on the serum proteome in 8 male patients by comparing the serum samples between acute and healed stages. Sample pooling and immunodepletion were applied for sample preparation. Two‐dimensional gel electrophoresis coupled with matrix‐assisted laser‐desorption ionization time‐of‐flight mass spectrometry (MALDI‐TOF‐TOF/MS) was utilized to identify and quantitate differentially expressed proteins. Changes in selected proteins were further confirmed by an ELISA assay.ResultsA total of 41 spots were quantitated with significant alteration (p<0.05; fold‐change≥± 3.0) in the serum between the acute and healed stages. Of these proteins, 26 proteins were identified by MALDI‐TOF‐TOF/MS. The identified proteins could be categorized into diverse functional classes, e.g., immunity and defense response, vitamin and lipid transport, fatty acid biosynthesis, actin binding, proteolysis and glycolysis. The ELISA assay confirmed the relative upregulation of calprotectin (S100A8/A9) and downregulation of retinol binding protein (RBP4) in the serum of the acute stage. The alteration of calprotectin and RBP4 was found to be specific to THD rather than trichloroethylene exposure.ConclusionsThe pathophysiological processes underlying THD may involve elevated inflammatory responses and oxidative stress, inhibition of vitamin transport, depression of fatty acid biosynthesis, loss of extracellular actin scavenger, increase in oxygen transport, dysfunction in lipid transport, proteolysis and glycolysis. The combination of higher calprotectin and lower RBP4 levels in the serum could be used as potential biomarkers of THD.
New Insights on the Impact of Mass to Volume and Volume to Volume as it Relates to Barium Sulphate Dissolver Performance
Authors: Jordan M. M. , Ajayi E. O. , Archibald M. 
Published: May 2012

Abstract
Dissolver technology has been developed and applied with varying degrees of success over the past few years to clean carbonate and the more challenging sulphate/sulphide scales from production tubing and process equipment. A common question that is often raised but which has no published experimental work to provide an answer is "under what liquid to solid ratio would a sulphate dissolver not be effective to clean production tubing?"
A set of experiments were conducted at a range of temperatures to review the impact of surface area/mass to fluid volume ratio for barium sulphate scale. The surface area/mass to fluid volume ratio were measured from 13 examples of scaled or partially scaled production tubing in an attempt to understand why in some laboratory tests dissolvers used to remove sulphate scale appear to show better performance than is observed in the field.
This paper shows that simple dissolver tests, when performed with high volume/volume ratio (1 part scale to 45 chemical) which equates to a mass to liquid volume ratio of 1:10 which is most commonly used in screening studies, can give misleadingly high performance information as they show enhanced dissolution rates and mass of scale dissolved. In fact, from the 13 scaled pipe sections examined in this work, a much higher ratio of solid mass to liquid volume (10:1 to 1:1) (equating to a volume/volume ratio of 1:4.5 to 2:1) is more typical and with these ratios dissolver performance is greatly reduced.
The results from these experiments are used to give a guide as to the measured liquid to solid ratio where sulphate dissolvers have the potential to work for barium and calcium sulphate scales and to where mechanical removal of the deposit would be the better treatment option.
Application of Silicate Scale Inhibitors for ASP Flooded Oilfields: A Novel Approach to Testing and Delivery
Authors: Sonne Jennifer , Kerr Scott , Miner Kirk 
Published: May 2012

Abstract
Silicate scaling is often induced by alkaline surfactant polymer (ASP) flooding in sandstone reservoirs. Scaling of the production tubing, rod or progressive cavity pumps, and other surface equipment causes frequent workovers, resulting in increased costs to the operator and non-productive time. The formation of silicate scale is complicated by its dependence on multiple factors including pH, silica concentration, and magnesium concentration, which vary as the flood progresses (Gill 1998). These factors affect silicate scaling tendency, and consequently, severity of the problem. Silicate scale inhibitors have been developed to mitigate problems in oilfields afflicted with silicate scaling due to ASP flooding (Qing et al. 2002). A new test method using an optical scanning device was developed to better characterize inhibition and dispersant qualities of the developed products on silicate scale in brine under static conditions. The advantage of this method is more comprehensive data generated by multiple-point measurements. Scaling reactions are more easily modified and differentiated. Water chemistries from several wells in an ASP-flooded field in Southern Alberta with known silicate scaling issues defined the tested synthetic brine. By allowing the mixed synthetic brine to react before adding inhibitor, the effect of delayed chemical injection may be studied. Performance of the tested inhibitor was significantly reduced by slight injection delay and may be attributable to the discrepancy between laboratory performance data and failures observed in the field. It is proposed that the performance of silicate scale inhibitors may be improved when applied by squeeze, where the inhibitor can inhibit silica polymerization within the formation and may provide substantial improvement over conventional continuous down-hole injection, where inhibitor reaches the water after the perforations.
Downhole Chemical Injection Lines - Why Do They Fail? Experiences, Challenges and Application of New Test Methods
Authors: Hustad Britt Marie , Svela Odd Geir , Olsen John Helge , Ramstad Kari , Tjomsland Tore 
Published: May 2012

Abstract
Statoil is operating several fields where downhole continuous injection of scale inhibitor is applied. The objective is to protect the upper tubing and safety valve from (Ba/Sr)SO4 or CaCO3 scale, in cases where scale squeezing may be difficult and costly to perform on a regular basis, e.g. tie-in of subsea fields.
Continuous injection of scale inhibitor downhole is a technically appropriate solution to protect the upper tubing and safety valve in wells that have scaling potential above the production packer; especially in wells that do not need to be squeezed on a regular basis due to scaling potential in the near wellbore area.
Designing, operating and maintaining the chemical injection lines demand extra focus on material selection, chemical qualification and monitoring. Pressure, temperature, flow-regimes and geometry of the system may introduce challenges to safe operation. Challenges have been identified in several kilometers' long injection lines from the production facility to the subsea template and in the injection valves down in the wells.
Field experiences showing the complexity of downhole continuous injection systems regarding precipitation and corrosion issues are discussed. Laboratory studies and application of new methods for chemical qualification are presented. The needs for multidisciplinary actions are addressed.
Flow Assurance in Complex Topside Processes with Subsea Tie-ins and Multiple Fluid Systems
Authors: Ramstad Kari , Rohde Hans Christian , Dalland Aslaug , Ponomareva Ekaterina , Johansen Pia 
Published: May 2012

Abstract
Economical field development strategy often implies tie-in of subsea satellite fields to nearby host installations. This leads to a whole new set of benefits and challenges considering design and material selection, production volumes and limitations, company strategies, holistic management and multi-disciplinary approaches. Operation of complex systems with multiple fluid streams demands a broader understanding of the chemical processes taking place when different fluids are mixed. Typical challenges include mineral scale and "soft scale" deposits. To ensure optimum production and provide flow assurance through chemical management, proper monitoring is essential. Guidelines and best practices are even more required if the tie-in to the host includes several operators and service companies.
Over the years, the Statoil operated Oseberg asset has through close cooperation with its chemical supplier M-I SWACO systematically improved the sampling and analysis procedures to strengthen the quality of data used in system monitoring. The supplier needs to have a strong focus on flow assurance related to chemical management and provide a range of onshore and offshore monitoring techniques and tools.
Challenges from the North Sea Oseberg Field Centre installation with subsea tie-ins have been discussed. Laboratory and field data from bottle tests, chemical analysis, preservation techniques and scaling potential simulations are presented. The results have been used to plan for side stream tests, develop guidelines for early identification of flow assurance challenges, sampling and monitoring of complex fluid systems and chemical management to avoid process upsets and production losses.
Development of a New Tagged Polymeric Scale Inhibitor with Accurate Low-level Residual Inhibitor Detection, for Squeeze Applications
Authors: Poynton Neil , Molliet Annabelle , Leontieff Andre , Cook Stuart , Toivonen Susanna , Griffin Rick 
Published: May 2012

Abstract
Effective monitoring of scale inhibitor residuals following a downhole squeeze can present challenges due a variety of reasons including contamination of the produced fluid with a topside scale inhibitor, and in the case of subsea wells, often the production is commingled as several wells flow through a single riser. The introduction of phosphorus-tagged scale inhibitors has partially solved the detection issue, but more tags are still needed for subsea developments in the North Sea and for use in commingled production. Detection limits and turnaround time of the sample analysis are also concerns. A new tagged scale inhibitor has been developed combining the proven performance of sulphonated co-polymers coupled with fluorescence technology, thus allowing the scale inhibitor to be detected using fluorescence spectroscopy.
This paper discusses the development of the technology for use in a North Sea field located 130 miles northeast of Aberdeen that has a downhole barium sulphate scaling risk. It is comprised of platform wells and subsea wells that tie back to the host platform via two shared risers. The operator was experiencing difficulties in detecting the subsea squeeze returns so this new tagged scale inhibitor was introduced in one of the wells to improve the monitoring of the squeeze returns. The scale inhibitor was detected successfully in the produced water samples by spectrofluorimetry and validated with gel permeation chromatography. The ultimate goal is to analyse residual squeeze inhibitors using a portable fluorimeter for onsite detection, enabling real-time monitoring of the squeeze returns.
The development of the chemistry and detection monitoring technique and the preliminary results from the field trial, and demonstrates the validity of the analysis method is discussed. This new chemistry, being detectable in mixed fluids, reduces the need for shutting in wells or well tests for sampling, thus minimising process instability due to re-routing wells and shut-in losses.
Risk Assessment of Calcium Naphtenates and Separation Mechanisms of Acidic Crude Oil
Authors: Passade-Boupat Nicolas , Gonzalez Marianna Rondon , Brocart Benjamin , Hurtevent Christian , Palermo Thierry 
Published: May 2012

Abstract
For over a decade, being able to accurately predict the risk of calcium naphthenate deposition has been one of the goals of production chemistry studies for development of new fields. In order to fulfill this challenge, many studies have been performed both within the company and through collaborations in JIPs. These studies have also shown specific behaviours of acidic crude oil / water separation depending on processing conditions. They have also permitted the improved detection and quantification of tetraprotic acids that are one of the main building blocks of these deposits. In this work, we will show how these findings have been incorporated into a workflow used to quantify naphthenate deposition risk. In particular, we will try to illustrate how the "other" naphthenic acids of the crude oil can behave as an efficient natural inhibitor of the deposits, and why, even if tetraprotic acids are detected in quite a large number of oils, only a limited number of fields have faced large scale issues related to calcium naphthenate deposits, due either to "good" process design or good fortune. "Simple" physicochemistry tests turn out to be very powerful tools in order to assess the macroscopic behavior of the naphthenic acids, and their influence on the risk analysis.