bluuebunny/crossref_metadata_2025_split huggingface dataset:
International evidence on alternative models of the term structure of volatilities
Authors: Díaz Antonio , Meneu Vicente , Navarro Eliseo 
Published: April 2009

AbstractThe term structure of instantaneous volatilities (TSV) of forward rates for different monetary areas (euro, U.S. dollar and British pound) is examined using daily data from at‐the‐money cap markets. During the sample period (two and a half years), the TSV experienced severe changes both in level and shape. Two new functional forms of the instantaneous volatility of forward rates are proposed and tested within the LIBOR Market Model framework. Two other alternatives are calibrated and used as benchmarks to test the accuracy of the new models. The two new models provide more flexibility to adequately calibrate the observed cap prices, although this improved accuracy in replicating cap prices produces some instability in parameter estimates. © 2009 Wiley Periodicals, Inc. Jrl Fut Mark 29:653–683, 2009
Genetic variation in the schizophrenia‐risk gene neuregulin 1 correlates with brain activation and impaired speech production in a verbal fluency task in healthy individuals
Authors: Kircher Tilo , Krug Axel , Markov Valentin , Whitney Carin , Krach Sören , Zerres Klaus , Eggermann Thomas , Stöcker Tony , Shah Nadim Jon , Treutlein Jens , Nöthen Markus M. , Becker Tim , Rietschel Marcella 
Published: April 2009

AbstractImpaired performance in verbal fluency tasks is an often replicated finding in schizophrenia. In functional neuroimaging studies, this dysfunction has been linked to signal changes in prefrontal and temporal areas. Since schizophrenia has a high heritability, it is of interest whether susceptibility genes for the disorder, such asNRG1, modulate verbal fluency performance and its neural correlates. Four hundred twenty‐nine healthy individuals performed a semantic and a lexical verbal fluency task. A subsample of 85 subjects performed an overt semantic verbal fluency task while brain activation was measured with functional magnetic resonance imaging (MRI).NRG1(SNP8NRG221533; rs35753505) status was determined and correlated with verbal fluency performance and brain activation. For the behavioral measure, there was a linear effect ofNRG1status on semantic but not on lexical verbal fluency. Performance decreased with number of risk‐alleles. In the fMRI experiment, decreased activation in the left inferior frontal and the right middle temporal gyri as well as the anterior cingulate gyrus was correlated with the number of risk‐alleles in the semantic verbal fluency task.NRG1genotype does influence language production on a semantic level in conjunction with the underlying neural systems. These findings are in line with results of studies in schizophrenia and may explain some of the cognitive and brain activation variation found in the disorder. More generally,NRG1might be one of several genes that influence semantic language capacities. Hum Brain Mapp, 2009. © 2009 Wiley‐Liss, Inc.
Tumor markers and rectal cancer: Support for an inflammation‐related pathway
Authors: Slattery Martha L. , Wolff Roger K. , Herrick Jennifer , Caan Bette J. , Samowitz Wade 
Published: April 2009

AbstractInflammation may be a key element in the etiology of colorectal cancer. In our study, we examine associations between factors related to inflammation and specific rectal cancer mutations. A population‐based study of 750 rectal cancer cases with interview and tumor DNA were compared to 1,205 population‐based controls. Study participants were from Utah and the Northern California Kaiser Permanente Medical Care Program. Tumor DNA was analyzed for TP53 and KRAS2 mutations and CpG Island methylator phenotype. We assessed how these tumor markers were associated with use of anti‐inflammatory drugs, polymorphisms in the IL6 genes (rs1800795 and rs1800796) and dietary antioxidants. Ibuprofen‐type drugs, IL6 polymorphisms (rs1800796) and dietary alpha‐tocopherol and lycopene significantly altered likelihood of having a TP53 mutation. This was especially true for TP53 transversion mutations and dietary antioxidants (OR for beta‐carotene 0.51 95% CI 0.27, 0.97, p trend 0.03; alpha‐tocopherol 0.41 95% CI 0.20, 0.84, p trend 0.02) Beta‐carotene and ibuprofen significantly altered risk of KRAS2 tumors. The associations between lutein and tocopherol and TP53 and KRAS2 mutations were modified by IL6 genotype. These results suggest that inflammation‐related factors may have unique associations with various rectal tumor markers. Many factors involved in an inflammation‐related pathway were associated with TP53 mutations and some dietary factors appeared to be modified by IL6 genotype. © 2009 UICC
The impact of zoledronic acid therapy in survival of lung cancer patients with bone metastasis
Authors: Zarogoulidis Kostantinos , Boutsikou Eufimia , Zarogoulidis Pavlos , Eleftheriadou Ellada , Kontakiotis Theodore , Lithoxopoulou Hellie , Tzanakakis George , Kanakis Ioannis , Karamanos Nikos K. 
Published: April 2009

AbstractBone metastases occur in 20–40% of patients with lung cancer. Recent studies demonstrate a direct antiproliferative effect of 3rd generation bisphosphonates (BPs) on lung tumors, which may influence the survival. Therefore, we examined the clinical impact of zoledronic acid (ZOL; Zometa®), a 3rd generation BP, with a focus on the survival, time to progression and pain effect in lung cancer patients with bone metastases. Lung cancer patients (n = 144, Stage IV) with evidence of metastasis bone scan were included. Eighty‐seven of 144 experienced bone pain and received ZOL, 4 mg i.v. every 21 days (Group A), whereas the other 57 patients received no ZOL (Group B). All patients were treated with a combination chemotherapy consisted of docetaxel 100 mg/m2 and carboplatin AUC = 6. It was found that Group A had a statistically significant longer survival (p < 0.01) when compared to Group B. A statistically significant positive correlation was found between the number of cycles of therapy with ZOL and total patient survival (p < 0.01, Pearson correlation) and time to progression (p < 0.01). Pain effect of ZOL had no significant difference between the 2 groups of patients (p > 0.05). Urine N‐telopeptide of type I collagen (NTx) levels decreased in patients with NTx ≤ 29 nM BCE/mM creatinine at baseline after treatment with ZOL. The results of our study suggest that the addition of ZOL increases overall survival in lung cancer patients with bone metastases. The longer period of receiving ZOL, the better effect on survival and time to progression. © 2009 UICC
Lung cancer secreted microvesicles: Underappreciated modulators of microenvironment in expanding tumors
Authors: Wysoczynski Marcin , Ratajczak Mariusz Z. 
Published: April 2009

AbstractMicrovesicles (MVs) are shed from cell membranes of several cell types and have an important function in cell‐to‐cell communication. Exponentially growing lung cancer cells secrete large quantities of MVs and we were interested in their role in tumor progression. We observed that both human and murine lung cancer cell lines secrete more MVs in response to non‐apoptotic doses of hypoxia and irradiation. These tumor‐derived (t)MVs activate and chemoattract stroma fibroblasts and endothelial cells. Furthermore, they induce expression of several pro‐angiopoietic factors in stromal cells such as IL‐8, VEGF, LIF, OSM, IL‐11 and MMP‐9. We also noticed that conditioned media harvested from stroma cells stimulated by tMVs enhanced the metastatic potential of both human and murine lung cancer cells in vivo. Thus, we postulated that tMVs are underappreciated constituents of the tumor microenvironment and play a pivotal role in tumor progression, metastasis and angiogenesis. © 2009 UICC
Dietary fat intake and risk of skin cancer: A prospective study in Australian adults
Authors: Ibiebele Torukiri I. , van der Pols Jolieke C. , Hughes Maria Celia , Marks Geoffrey C. , Green Adèle C. 
Published: April 2009

AbstractAlthough intakes of dietary fat have been associated with both basal cell carcinoma (BCC) and squamous cell carcinoma (SCC) of the skin, the evidence is sparse and inconsistent. This study prospectively investigated the association between total dietary fat; saturated, polyunsaturated and monounsaturated fatty acids; and percent energy from fat in relation to BCC and SCC of the skin. At baseline in 1992, total fat intake and intake of fatty acids were assessed in an Australian community‐based longitudinal study, using a validated semi‐quantitative food frequency questionnaire in 1,057 adult residents (aged 25–75 years) in Nambour, Queensland. Information on demography, sun‐sensitivity history and sun exposure factors were obtained using self‐administered questionnaires. Associations with BCC and SCC in terms of persons newly affected and of tumor counts were assessed using Poisson and negative binomial regression models, respectively, based on incident, histologically‐confirmed tumors occurring between 1992 and 2002. No significant linear trends were observed in overall risk of BCC or SCC of the skin with increasing total fat intake. However, in participants with a history of skin cancer, total fat intake (multivariable adjusted RR = 2.42, 95% CI = 1.20–4.88; p for trend = 0.01) was associated with increased numbers of SCC tumors comparing the highest to lowest tertile. In conclusion, SCC tumor risk increased as total fat intake increased in people with a history of skin cancer. Dietary fats were not associated with BCC occurrence. © 2009 UICC
Rimonabant inhibits human colon cancer cell growth and reduces the formation of precancerous lesions in the mouse colon
Authors: Santoro Antonietta , Pisanti Simona , Grimaldi Claudia , Izzo Angelo A. , Borrelli Francesca , Proto Maria C. , Malfitano Anna M. , Gazzerro Patrizia , Laezza Chiara , Bifulco Maurizio 
Published: April 2009

AbstractThe selective CB1 receptor antagonist rimonabant (SR141716) was shown to perform a number of biological effects in several pathological conditions. Emerging findings demonstrate that rimonabant exerts antitumor action in thyroid tumors and breast cancer cells. In our study, human colorectal cancer cells (DLD‐1, CaCo‐2 and SW620) were treated with rimonabant and analyzed for markers of cell proliferation, cell viability and cell cycle progression. Rimonabant significantly reduced cell growth and induced cell death. In addition, rimonabant was able to alter cell cycle distribution in all the cell lines tested. Particularly, rimonabant produced a G2/M cell cycle arrest in DLD‐1 cells without inducing apoptosis or necrosis. The G2/M phase arrest was characterized by a parallel enhancement of the number of mitoses associated to elevated DNA double strand breaks and chromosome misjoining events, hallmarks of mitotic catastrophe. Protein expression analyses of Cyclin B1, PARP‐1, Aurora B and phosphorylated p38/MAPK and Chk1 demonstrated that rimonabant‐induced mitotic catastrophe is mediated by interfering with the spindle assembly checkpoint and the DNA damage checkpoint. Moreover, in the mouse model of azoxymethane‐induced colon carcinogenesis, rimonabant significantly decreased aberrant crypt foci (ACF) formation, which precedes colorectal cancer. Our findings suggest that rimonabant is able to inhibit colorectal cancer cell growth at different stages of colon cancer pathogenesis inducing mitotic catastrophein vitro. © 2009 UICC.
Energetics of [Fe(NCH)6]2+ via CASPT2 calculations: A spin‐crossover perspective
Authors: Kepenekian Mikaël , Robert Vincent , Le Guennic Boris , De Graaf Coen 
Published: April 2009

AbstractThe importance of basis sets and active spaces in the determination of the potential energy curves and relevant energy differences in the Oh‐symmetry model system [Fe(NCH)6]2+ is analyzed using the Complete Active Space Self‐Consistent Field (CASSCF) method and subsequent second‐order perturbative treatment (CASPT2). By comparison of a series of atomic basis sets contraction, it is concluded that a balanced description of the Fe 7s6p5d3f2g1h and N 4s3p1d partners is needed to reach convergence upon the potential energy surface descriptions. Since the spin‐crossover phenomenon involves the simultaneous change in the spin nature and expansion of the coordination sphere of the metal ion (i.e., lengthening of the Fe‐N distances), the standard 10 electrons/12 orbitals complete active space is confronted to a chemically intuitive 18 electrons/15 orbitals picture. The role of a second d‐shell is finally examined using the extended RAS strategy. Using a valence‐bond type analysis, it is shown that the so‐called d′ orbitals allow for a significant charge redistribution (∼0.5 electron) along the transition. Our calculations are compared to reference coupled‐cluster estimations. © 2009 Wiley Periodicals, Inc. J Comput Chem, 2009
Valorisation of agro‐industrial by‐products, effluents and waste: concept, opportunities and the case of olive mill wastewaters
Authors: Federici Federico , Fava Fabio , Kalogerakis Nicolas , Mantzavinos Dionissios 
Published: April 2009

AbstractValorisation is a relatively new concept in the field of industrial residues management promoting the principle of sustainable development. One of the valorisation objectives regarding food processing by‐products, waste and effluents is the recovery of fine chemicals and the production of precious metabolites via chemical and biotechnological processes. This paper identifies and discusses certain directions that seem to advance valorisation, as well as existing limitations that need to be overcome in the food processing sector. A valorisation strategy is exemplified for the wastewaters arising from the olive oil extraction process; the recovery of antioxidants by chemical methods and the fermentative production of enzymes of commercial interest have been reviewed. Copyright © 2009 Society of Chemical Industry
Use of native species and biodegradable chelating agents in the phytoremediation of abandoned mining areas
Authors: Cao Alessia , Carucci Alessandra , Lai Tiziana , Bacchetta Gianluigi , Casti Mauro 
Published: April 2009

AbstractBACKGROUND: The application of phytostabilization and assisted phytoextraction to the remediation of abandoned mining areas can be a valuable method to reclaim these areas without modifying soil and landscape characteristics. An in situ application of a continuous phytoextraction technique was carried out in the area of Campo Pisano (Sardinia, Italy), followed by a laboratory assisted phytoextraction test using the biodegradable chelating agents methylglycine diacetic acid (MGDA) and iminodissuccinic acid (IDSA). The plants used were Scrophularia canina subsp. bicolor, Cistus salviifolius and Teucrium flavum subsp. glaucum.RESULTS: The plant that accumulated more Pb was T. glaucum (353 mg kg−1) while C. salviifolius demonstrated better ability to accumulate Zn (1560 mg kg−1). S. bicolor showed a better tolerance to metals but accumulated 119 mg kg−1 of Pb. Accumulation of metals immediately after chelant application was up to 300 mg kg−1 of Pb and 3000 mg kg−1 of Zn which did not further increase during the assisted phytoextraction experiment.CONCLUSION: The plant that demonstrated to be most suitable for phytoremediation application was S. bicolor due to its higher biomass production and tolerance to metals. The low cation exchange capacity and the high concentration of Ca and Mg in soil determined a low chelant effectiveness. Copyright © 2009 Society of Chemical Industry
Does acquired resistance of rodent hosts affect metabolic rate of fleas?
Authors: Khokhlova Irina S. , Ghazaryan Lusine , Krasnov Boris R. , Degen A. Allan 
Published: April 2009

AbstractWe studied whether (a) previous infestation of a rodent host with fleas and (b) the reproductive effort of fleas affect the rate of CO2 emission in two flea species, host‐specific Parapulex chephrenis and host‐opportunistic Xenopsylla ramesis when feeding on their typical and atypical rodent hosts. We measured the rate of CO2 emission in preovipositing and ovipositing female fleas fed on either pristine or previously infested Acomys cahirinus (typical host of P. chephrenis) and Dipodillus dasyurus (typical host of X. ramesis). When P. chephrenis fed on a typical host, its mass‐specific rate of CO2 emission was not affected by previous infestation of a host, whereas when this flea fed on the atypical host, its rate of CO2 emission was higher when a host was previously infested. This was manifested, however, mainly during the oviposition period. The rate of CO2 emission by X. ramesis feeding on pristine hosts was significantly lower than in conspecifics feeding on previously infested hosts, independent of host species. Both flea species feeding on their typical hosts emitted CO2 at similar mass‐specific rates during preoviposition and oviposition, except for P. chephrenis feeding on D. dasyurus, which increased its rate during oviposition. There was no effect of the number of eggs produced per female on the rate of CO2 emission during oviposition. J. Exp. Zool. 311A:389–398, 2009. © 2009 Wiley‐Liss, Inc.
The determining number of a Cartesian product
Authors: Boutin Debra L. 
Published: April 2009

AbstractA set S of vertices is a determining set for a graph G if every automorphism of G is uniquely determined by its action on S. The determining number of G, denoted Det(G), is the size of a smallest determining set. This paper begins by proving that if G=G□⋅□G is the prime factor decomposition of a connected graph then Det(G)=max{Det(G)}. It then provides upper and lower bounds for the determining number of a Cartesian power of a prime connected graph. Further, this paper shows that Det(Qn)=⌈log2n⌉+1 which matches the lower bound, and that Det(K)=⌈log3(2n+1)⌉+1 which for all n is within one of the upper bound. The paper concludes by proving that if H is prime and connected, Det(Hn)=Θ(logn). © 2009 Wiley Periodicals, Inc. J Graph Theory
Planar graphs without 4‐cycles are acyclically 6‐choosable
Authors: Wang Weifan , Chen Min 
Published: April 2009

AbstractA proper vertex coloring of a graph G=(V, E) is acyclic if G contains no bicolored cycle. A graph G is acyclically L‐list colorable if for a given list assignment L={L(v)|v∈V}, there exists a proper acyclic coloring π of G such that π(v)∈L(v) for all v∈V. If G is acyclically L‐list colorable for any list assignment with |L(v)|≥k for all v∈V, then G is acyclically k‐choosable. In this paper we prove that every planar graph G without 4‐cycles is acyclically 6‐choosable. © 2009 Wiley Periodicals, Inc. J Graph Theory 61: 307–323, 2009
Characterizing path graphs by forbidden induced subgraphs
Authors: Lévêque Benjamin , Maffray Frédéric , Preissmann Myriam 
Published: April 2009

AbstractA path graph is the intersection graph of subpaths of a tree. In 1970, Renz asked for a characterization of path graphs by forbidden induced subgraphs. We answer this question by determining the complete list of graphs that are not path graphs and are minimal with this property. © 2009 Wiley Periodicals, Inc. J Graph Theory 62: 369–384, 2009
A facile synthesis of unsymmetrical heterocyclic azines by cyclodesulfurization: Reaction of methyl arylalkylidenehydrazinecarbodithioates with diamines
Authors: Lin Ai Jeng , Klayman Daniel L. 
Published: April 2009

AbstractA new and facile synthesis of unsymmetrical heterocyclic azines is described. Methyl arylalkylidenehydraz‐inecarbodithioates, prepared by the condensation of ketones or aldehydes with methyl hydrazinecarbodithioate, were heated under reflux with various diamines in ethanol. Secondary diamines, such as N,N′‐dimethyl‐ethylenediamine, N,N′‐dimethyl‐1,3‐diaminopropane or N,N′‐dimethyl‐o‐phenylenediamine, reacted smoothly with loss of hydrogen sulfide to give good yields of unsymmetrical azines. However, primary diamines, such as ethylenediamine or o‐phenylenediamine, and primary/secondary diamines, such as N‐methylethyl‐enediamine and N‐methyl‐1,3‐diaminopropane gave, instead, only the corresponding uncyclized thiosemi‐carbazones. A cyclodesulfurization mechanism for azine formation is discussed.
Monocyclic pteridine analogues. A pyrazine analogue of methotrexate
Authors: Lever O. William , Vestal B. Randall 
Published: April 2009

AbstractReaction of aminocyanoacetamide with bromomethylpyruvaldoxime provided 3‐amino‐6‐bromomethyl‐2‐carbamoylpyrazine 4‐oxide (7), which was converted to a pyrazine analogue (3) of methotrexate by subsequent condensation with diethyl N‐[4‐(methylamino)benzoyl]‐L‐glutamate, deoxygenation, and hydrolysis. The methotrexate analogue 3 was a poor inhibitor (I50 > 150 μM) of bacterial or mammalian dihydrofolate reductase.
New synthesis of 2,4‐dialkyl(or diaryl)pyrazolo[1,5‐a]‐1,3,5‐triazines
Authors: Strohmeyer Timothy W. , Sliskovic D. Robert , Lang S. A. , Lin Yang‐I 
Published: April 2009

AbstractReactions of monothiodiacylamines or N‐aroylthioimidates with 3‐aminopyrazoles gave pyrazolo[1,5‐a]‐1,3,5‐triazines in good yields.
Lead tetraacetate oxidation of phenylhydrazones of 3‐benzoylazoles. Synthesis of azoacetates and their conversion into indazoles
Authors: Vivona Nicolò , Frenna Vincenzo , Buscemi Silvestre , Condò Michele 
Published: April 2009

AbstractLead tetraacetate (LTA) oxidation of (E)‐ and (Z)‐phenylhydrazones of 3‐benzoyl‐5‐phenyl‐1,2,4‐oxadiazole, 3‐benzoyl‐5‐phenylisoxazole, and 3‐benzoyl‐4‐methyl‐1,2,5‐oxadiazole has been studied. Conversion of azoacetate products into 3‐(azol‐3‐yl)‐substituted indazoles has been achieved by reacting them with aluminium chloride in benzene at room temperature.
Synthèse d'analogues furanniques du benzo[a]pyrène
Authors: Demerseman Pierre , Einhorn Jacques , Royer René , Gourvest Jean‐FrançOis 
Published: April 2009

AbstractOn décrit les synthèses à partir du bromo‐1 pyrène, des deux analogues furanniques du benzo[a]pyrène, les pyréno[1,2‐b]furanne et pyréno[2,1‐b]furanne, ainsi que de leurs dérivés nitrés sur l'hétérocycle.
Synthèse du benzoyl‐3 chromanol‐4 et du benzoyl‐3 2H‐chromène
Authors: Bellassoued‐Fargeau Marie‐Claude , Maitte Pierre 
Published: April 2009

AbstractL'addition de la phénylvinylcétone sur l'aldéhyde salicylique en milieu basique conduit toujours à un mélange de benzoyl‐3 chromanol‐4 et de benzoyl‐3 2H‐chromène. Les structures de ces composés sont déterminées par spectroscopie ir et rmn.
Conformational analysis of 3‐ketopiperidines. Vicinal N1C(2)‐alkyl interactions
Authors: Katvalyan H. T. , Shashkov A. S. , Mistryukov E. A. 
Published: April 2009

AbstractChemical equilibration and 1H‐nmr spectroscopic studies on 1,2,5‐substituted 3‐ketopiperidines have been carried out. With the bulky t‐butyl group on nitrogen the C(2)‐methyl substituent is highly favored in the axial configuration. This phenomenon constitutes the basis of an efficient method of controlling diastereomer stabilities by varying the nitrogen substituent in the 3‐keto‐ and 4‐ketopiperidine series.
4‐Lithio‐1‐tritylimidazole as a synthetic intermediate. Synthesis of imidazole‐4‐carboxaldehyde
Authors: Kirk Kenneth L. 
Published: April 2009

AbstractReaction of 4‐iodo‐1‐tritylimidazole with n‐butyllithium at –79°, followed by rapid quenching of the reaction mixture with DMF, gives good yields of 1‐tritylimidazole‐4(5)‐carboxaldehyde, the isolation of which demonstrates the intermediacy of 4‐lithio‐1‐tritylimidazole. This species should be destabilized by repulsive interaction of the negative charge on C‐4 with the adjacent lone pair electrons on N‐3 (the ALP effect). The isolation of 1‐tritylimidazole‐4(5)‐carboxaldehyde in good yield and the versatility of the aldehyde functionality make 4‐lithio‐1‐tritylimidazole a useful synthetic intermediate.