bluuebunny/crossref_metadata_2025_split huggingface dataset:
Tensor modeling of MRSA bacteremia cytokine and transcriptional patterns reveals coordinated, outcome-associated immunological programs
Authors: Chin Jackson L , Tan Zhixin Cyrillus , Chan Liana C , Ruffin Felicia , Parmar Rajesh , Ahn Richard , Taylor Scott D , Bayer Arnold S , Hoffmann Alexander , Fowler Vance G , Reed Elaine F , Yeaman Michael R , Meyer Aaron S ,   with the MRSA Systems Immunobiology Group, Rajesh Parmar , Ahn Richard , Bayer Arnold S , Chan Liana , Chang Yu-Ling , Filler Scott G , Fowler Vance G , Gjertson David , Hoffmann Alexander , Medie Felix , Mitchell Simon , Reed Elaine F , Rossetti Maura , Ruffin Felicia , Qin Yan , Sharma Batu , Sheu Katherine , Thaden Joshua , Waring Alan J , Xiong Yan Q , Zheng Ying , Yeaman Michael R 
Published: May 2024

Abstract
Methicillin-resistant Staphylococcus aureus (MRSA) bacteremia is a common and life-threatening infection that imposes up to 30% mortality even when appropriate therapy is used. Despite in vitro efficacy determined by minimum inhibitory concentration breakpoints, antibiotics often fail to resolve these infections in vivo, resulting in persistent MRSA bacteremia. Recently, several genetic, epigenetic, and proteomic correlates of persistent outcomes have been identified. However, the extent to which single variables or their composite patterns operate as independent predictors of outcome or reflect shared underlying mechanisms of persistence is unknown. To explore this question, we employed a tensor-based integration of host transcriptional and cytokine datasets across a well-characterized cohort of patients with persistent or resolving MRSA bacteremia outcomes. This method yielded high correlative accuracy with outcomes and immunologic signatures united by transcriptomic and cytokine datasets. Results reveal that patients with persistent MRSA bacteremia (PB) exhibit signals of granulocyte dysfunction, suppressed antigen presentation, and deviated lymphocyte polarization. In contrast, patients with resolving bacteremia (RB) heterogeneously exhibit correlates of robust antigen-presenting cell trafficking and enhanced neutrophil maturation corresponding to appropriate T lymphocyte polarization and B lymphocyte response. These results suggest that transcriptional and cytokine correlates of PB vs. RB outcomes are complex and may not be disclosed by conventional modeling. In this respect, a tensor-based integration approach may help to reveal consensus molecular and cellular mechanisms and their biological interpretation.
Exercise referral schemes in the UK: mapping provision and aims
Authors: Jane Ben , Downey John 
Published: May 2024

Abstract

Background
Exercise Referral Schemes (ERS) are designed so health professionals can refer certain patients to a supervised programme of physical activity. However, evaluations have questioned the effectiveness of these schemes/programmes. The aim of this study was to systematically review the provision of ERS in England and analyse related promotional material.

Methods
Content analysis methods were used to analyse scheme websites and promotional material. A coding scheme was used to analyse the data, which included information on the programme’s aims, inclusion criteria, type of activities, accessibility and cost.

Results
The study identified 625 sites offering ERS across 168 geographic areas. Findings highlighted a lack of clarity in what constitutes a scheme. Over a third of schemes did not explicitly state their aims, but of those that did, the focus was mainly on notions of physical and mental health benefits.

Conclusions
This study is the first to review the scope and offer of ERS in the UK by examining promotional material and highlights issues around the stated aims of ERS. More clarity on aims is needed in the material that promotes the schemes and most likely within the schemes themselves. Such improvements could make a difference when considering engagement with delivery stakeholders and potential participants.
The impact of earthquakes on women: assessing women's mental health in aftermath of the Kahramanmaraş-centred earthquake in Türkiye
Authors: Kaplan Veysel , Alkasaby Muhammad , Düken Mehmet Emin , Kaçkin Özlem , Riad Abanoub 
Published: May 2024

Abstract

Background
Earthquakes disproportionately affect women and exacerbate gender and social inequalities. This study aims to investigate the psychological impact of the earthquake in Türkiye on women and the associated factors.

Methods
This is a survey-based study. We collected data from 498 women residing in cities most affected by the earthquake.

Results
Participants’ mean age was 27.72 ± 5.4. Over 78% of the participants lost at least one family member, and 43.7% lost at least one child due to the earthquake. The mean average of Brief Symptom Inventory (BSI) scores was 100.8 (SD = 8.37), and the Global Severity Index was 1.9 (SD = 0.16). Regression analysis showed that higher education levels predicted poor outcomes across most BSI dimensions. Losing a family member and shelter and injury status were also predictors for several mental health outcomes of the BSI subscales.

Conclusions
Earthquakes significantly impact women’s well-being and may have a broader impact on the whole family. There is an urgent need to provide psycho-social interventions in the response and recovery phases of the crisis to meet the affected women’s needs. This includes providing basic needs with attention to women-specific needs, restoring social networks, addressing gender-based violence and providing gender-sensitive specialized interventions for those who need further support.
Relationship between children’s eating behavior (1–6 years) and body mass index: a cross-sectional study in French maternal–infant protection centers within the Parisian region
Authors: Serhal Laudy , Fardet Anthony , Obeid Dalia 
Published: May 2024

Abstract

Background
Early detection of obesity-promoting dietary behavior patterns improves the identification of at-risk families and the implementation of interventions. This is accomplished through the use of the Child Eating Behavior Questionnaire (CEBQ). No study has been conducted using the CEBQ in children followed in Essonne’s Maternal–Infant Protection (PMI) centers. We investigated, in a cross-sectional design, the differences in children’s eating behavior with PMI follow-up according to their weight status.

Methods
A questionnaire addressed to parents was collected in PMI centers. Multiple hierarchical regression analysis was used to investigate the predictability of the child’s CEBQ on body mass index (BMI).

Results
From January to April 2022, 850 children were selected, from which 500 (aged 1–6 years) were included, and of whom 10.6% were obese. There was a significant positive association between ‘Food Responsiveness’, ‘Enjoyment of Food’ and BMI. In contrast, there was a significant negative association between ‘Satiety Responsiveness’, ‘Slowness in Eating’ and BMI. Besides, ‘Food approach’ and ‘food avoidance’ behaviors were positively and negatively related to BMI z-scores, respectively.

Conclusion
Due to significant differences in children’s eating behavior according to their weight, it is needed to raise awareness among parents about their impact on them.
A longitudinal study combining the Double Diamond framework and Behavior Change Wheel to co-create a sedentary behavior intervention in police control rooms
Authors: Oliver Helen , Thomas Owen , Neil Rich , Copeland Robert J , Moll Tjerk , Chadd Kathryn , Jukes Matthew J , Quartermaine Alisa 
Published: May 2024

Abstract

Background
Police work can be sedentary and stressful, negatively impacting health and wellbeing. In a novel co-creation approach, we used the Behavior Change Wheel (BCW) and Double Diamond (DD) design framework to guide the collaborative design and development of a sedentary behavior intervention in the control rooms of two British police forces.

Methods
Multiple stakeholders participated in four phases of research. In Phase 1, a literature review, focus groups (n = 20) and interviews (n = 10) were conducted to ‘discover’ the relationship between physical activity and wellbeing in the police. In Phase 2, a steering group consolidated Phase 1 findings to ‘define’ a specific behavior for intervention. Phases 3 and 4 ‘developed’ the intervention across six workshops with control room workers and six steering group workshops.

Results
The co-creation process identified contextual sedentary behavior as the target behavior, driven by behavioral regulation, social influence and social norms. The sedentary behavior intervention targeted these drivers and aimed to engage control room workers in short bursts of physical activity throughout their shifts. Key intervention features targeted involvement of staff in decision-making and embedding physical activity into work practices.

Conclusions
The BCW and DD can be combined to co-create evidence-based and participant-informed interventions and translate science into action.
High-radiation-exposure tasks in Korean pressurized heavy-water reactors
Authors: Song Changju , Kong Tae Young , Kim Seongjun , Son Jinho , Kim Jiung , Park Jaeok , Kim Hee Geun , Kim Yongkwon 
Published: May 2024

Abstract
This study analysed the occupational dose in Korean pressurized heavy-water reactors (PHWRs) and identified tasks involving high radiation exposure. The average individual dose was sufficiently low to be below the annual effective dose limit for radiation workers and is even lower than the dose limit for the general public. However, some workers received relatively higher doses than others. Furthermore, most PHWR workers are exposed to radiation during planned maintenance periods. In this study, the radiation dose was normalized (radiation dose per unit time) to determine the high-radiation-exposure tasks in Korean PHWRs. Consequently, end-fitting lapping, delayed neutron tube work and fuel channel fixed-end change tasks were identified as high-radiation-exposure tasks in Korean PHWRs. If appropriate radiation protection measures are prioritized for the identified high-dose exposure tasks, optimization of radiological protection will be effectively achieved by reducing the dose that is relatively higher than the average.
Outcomes of Aggression and Victimization in Social Welfare Services
Authors: Hadar Keren , Enosh Guy , Tzafrir Shay S 
Published: May 2024

Abstract
This study examined two significant phenomena that occur in the workplace, aggression and victimization, and their outcomes. The study’s participants were 470 social workers employed by social welfare services in Israel. The examined outcomes were stress symptoms, emotional exhumation, and decline in quality of service climate. The associations between aggression, victimization, and their outcomes were examined via linear regression during Stata 14. The study found that the similar outcomes of aggression and victimization are stress symptoms and emotional exhaustion, while service climate (decline in quality) was associated only with victimization. While most studies have examined mainly victimization outcomes, the current study examined both aggression and victimization outcomes. This article sheds light on the similarities and the difference of outcomes between aggression and victimization and explicates the phenomena of workplace aggression from two important and complementary aspects of aggression and victimization. It is important to refer to either aggression or victimization while considering workplace aggression. Authors recommend for further studies to continue to investigate both aggression and victimization while researching workplace aggression outcomes.
Lessons learned from using wild-caught and captive-reared lesser scaup (Aythya affinis) in captive experiments
Authors: Beach Cheyenne R , Jacques Christopher N , Lancaster Joseph D , Osborne Douglas C , Yetter Aaron P , Cole Rebecca A , Hagy Heath M , Fournier Auriel M V 
Published: May 2024

Abstract
Waterfowl are housed in captivity for research studies that are infeasible in the wild. Accommodating the unique requirements of semi-aquatic species in captivity while meeting experimental design criteria for research questions can be challenging and may have unknown effects on animal health. Thus, testing and standardizing best husbandry and care practices for waterfowl is necessary to facilitate proper husbandry and humane care while ensuring reliable and repeatable research results. To inform husbandry practices for captive-reared and wild-caught lesser scaup (Aythya affinis; hereafter, scaup), we assessed body mass and fat composition across two different aspects of husbandry, source population (captive-reared or wild caught), and housing densities (birds/m2). Our results suggest that housing scaup at low densities (≤0.6 m2/bird, P = 0.049) relative to other species can minimize negative health effects. Captive-reared scaup were heavier (P = 0.027) with greater body fat (P &lt; 0.001) and exhibited fewer signs of stress during handling than wild-caught scaup. In our experience, scaup which are captive-reared from eggs collected in the wild were better for long-term captivity studies as they maintained body mass between and recovered lost body mass following trials. Researchers would benefit from carefully evaluating the tradeoffs of using short- and long-term captive methods on their research question before designing projects, husbandry practices, and housing facilities for waterfowl.
Association of T-cell receptor repertoires and arterial stiffness in patients with essential hypertension
Authors: Ma Xiaoxiang , Zhuo Yue , Zhang Zhixin , Yang Yanhua , He Pengming , Zeng Yi , Huang Yan , Wen Xueping 
Published: May 2024

Background:
Abnormal immune responses, particularly T-cell activity, are linked to vascular complications in hypertension, but mechanisms remain unknown. Our study aims to explore the association between arterial stiffness, assessed by brachial–ankle pulse wave velocity (baPWV), and T-cell receptor (TCR) repertoires in essential hypertension patients, focusing on understanding the role of T cells in the development of arterial stiffness in this population.

Methods:
The study included 301 essential hypertension patients and 48 age-matched normotensive controls. Essential hypertension patients were stratified into high (baPWV ≥1400 cm/s, n = 213) and low (baPWV <1400 cm/s, n = 88) baPWV groups. High-throughput sequencing analyzed peripheral TCRβ repertoires.

Results:
Significant TCRβ repertoire differences were observed between essential hypertension and normotensive groups, as well as between high and low baPWV essential hypertension subgroups. Specifically, patients in the high baPWV group exhibited notable variations in the utilization of specific TCR beta joining (TRBJ) and variable (TRBV) genes compared to the low baPWV group. These alterations were accompanied by reduced TCRβ diversity (represented by diversity 50 s), increased percentages of the largest TCRβ clones, and a higher number of TCRβ clones exceeding 0.1%. The presence of specific TCRβ clones was detected in both groups. Furthermore, reduced diversity 50s and elevated percentages of the largest TCRβ clones were independently correlated with baPWV, emerging as potential risk factors for increased baPWV in essential hypertension patients.

Conclusion:
TCR repertoires were independently associated with arterial stiffness in patients with essential hypertension, implicating a potential role for dysregulated T-cell responses in the pathogenesis of arterial stiffness in this patient population.

Trial registration: ChiCTR2100054414.
Is this an adenocarcinoma? A case report of extragenital endometriosis with hydroureteronephrosis
Authors: Adhikari Prawesh , Rana Aakanksha , Karki Gaurav , Shah Kunda Bikram 
Published: May 2024

Introduction and importance:
Endometriosis is a prevalent condition within the female reproductive age group, but its presentation and diagnosis still pose a challenge as it mimics other diseases and affects multiple organ systems.

Case presentation:
A 24-year-old nulliparous female presented with complaints of menorrhagia, lower abdominal pain, post-coital bleeding, and significant weight loss for 7 months.

Clinical discussion:
The case highlights the challenge of diagnosing endometriosis due to its ability to mimic other conditions, such as carcinoma cervix and rectum. The presence of elevated Cancer Antigen-125 (CA-125), typically associated with malignancy, underscores the need for a comprehensive evaluation to differentiate between endometriosis and other pathologies. Furthermore, the involvement of multiple organ systems emphasizes the systemic nature of endometriosis and the importance of considering it in the differential diagnosis of pelvic masses and symptoms in young women.

Conclusion:
Endometriosis, although a common disease among females of reproductive age its variation in presentation causes significant misdiagnosis and undertreatment. Multi-modal diagnosis and early treatment are necessary for proper outcomes.
Acute coronary syndrome in young (≤45 years) patients: a multi-centre observational study
Authors: Shrateh Oadi N. , Al-Tawil Mohammed , Awad Areej , Zeer Zahraa M.M. , Owais Tarek A. , Sinokrot Amro , Zuaiter Bashar , Thraiee Yazan , Ahmed Amani , abo Jheasha Amal , Alrojoub Saba , Hour Shayma , Mtour Ali , Arda Yasmin , Zuaiter Kareem , Jamee Amal , Mtour Sameer , Nassr Mohammed , Neirat Shaker 
Published: May 2024

Introduction:
Acute coronary syndrome (ACS) in young individuals (≤45 years) is increasingly recognized as a significant health concern, yet research in this demographic remains limited, particularly within the Palestinian context. This study aims to bridge this gap by comprehensively investigating the clinical characteristics, age-specific profiles, gender disparities, treatment modalities, and angiographic patterns of ACS in young patients compared to their older counterparts.

Materials and methods:
A multi-centre observational study was conducted, enroling 468 participants aged 18–55 diagnosed with ACS and admitted to three prominent Palestinian hospitals. Data were collected from medical records, and statistical analysis was performed to assess demographic characteristics, clinical presentations, risk factors, treatment strategies, and outcomes.

Results:
The majority of participants were male (87%), with a higher proportion in the older age group (>45 years). Clinical presentations varied, with non-ST segment elevation myocardial infarction (NSTEMI) being the most common diagnosis (48%). Risk factors such as smoking, hypertension, and diabetes were prevalent, with notable gender and age-specific differences. Percutaneous coronary intervention (PCI) was the predominant treatment strategy (83%), with consistent medication use across age groups.

Conclusion:
ACS in young patients poses a significant public health challenge in Palestine, necessitating tailored preventive strategies and comprehensive management approaches. Understanding the unique demographic and clinical characteristics of young ACS patients is crucial for informing targeted interventions and policies aimed at reducing the burden of cardiovascular disease in this population. These findings contribute valuable insights to the existing literature and underscore the importance of further research in this area to improve outcomes and mitigate the impact of ACS in young individuals globally.
Denosumab and metatarsal fracture healing: potential benefits with delayed remodeling: a case report
Authors: Aldhilan Mansour M. , Almahamed Mousaed H. , Abdel-Wanis Mohamed E. 
Published: May 2024

Background:
Denosumab is known to enhance callus formation while delaying remodeling. However, its effects on fracture healing are scarcely reported in the literature. This case report, to the best of our knowledge, is the first to report the potential effect of denosumab on a metatarsal fracture in an older adult patient, 4 months after administration, resulting in a favorable clinical course with early weight-bearing 17 days after the fracture.

Presentation of case:
A 73-year-old female sustained a right-foot second metatarsal fracture due to the fall of a heavy object. She has a history of diabetes mellitus, hypertension, and osteoporosis. Prior to sustaining the fracture, she received seven doses of denosumab spaced 6 months apart, with the last dose administered 4 months earlier. Furthermore, the patient was treated with a backsplint for 6 weeks. After 17 days, follow-up radiographs showed a large callus formation, with no pain and the ability to bear weight. Subsequent radiographs revealed a large callus with delayed remodeling.

Discussion:
This case report suggests that denosumab remains effective for promoting rapid callus formation even 4 months after administration for osteoporosis, despite delayed remodeling. This delay did not seem to have negative effects on the clinical outcomes, as the patient achieved weight-bearing within 17 days after sustaining the fracture.

Conclusion:
Denosumab may positively influence fracture healing in older adults with metatarsal fractures, potentially leading to delayed remodeling. However, further studies are needed to confirm these observations.
Superior mesenteric artery syndrome misdiagnosed and preceded by Helicobacter pylori-induced gastritis: a rare diagnosis with misleading features
Authors: Ismail Sawsan , Hasan Mohammad , Aljasem Muhamad , Darkaznli Mohamad Ismaeel , Habib Alice , Deeb Hala , Alkhalil Batool , Sheikh Mohamad Lalsh , Khalil Aleen , Kattash Shatha , Arja Joudi , Haydar Khalil 
Published: May 2024

Introduction and importance:
Superior mesenteric artery (SMA) syndrome is a rare morbid vascular disorder that is defined as the decrease in the aortomesenteric angle and the compression of the third part of the duodenum. This disorder mainly affects young adult females, and severe weight loss represents a leading predisposing factor.

Case presentation:
The authors report the case of a 19-year-old male who was admitted to our hospital with a 3-month history of epigastric pain, nausea, and weight loss. Two months earlier, the patient was diagnosed with Helicobacter pylori-induced gastritis. Nevertheless, with complaints of severe headache and epigastric pain, the patient was admitted to our hospital for further investigations. Computed tomography (CT) scan with intravenous contrast injection was performed, and interestingly, the aortomesenteric angle was 19° accompanied by a compression of the third part of the duodenum, and a mild gastric dilatation. Accordingly, the diagnosis was confirmed as superior mesenteric artery syndrome.

Clinical discussion:
In the authors’ case, the non-specific clinical symptoms correlated with histopathological examinations led to the initial diagnosis of Helicobacter pylori-induced gastritis. Surprisingly, the lack of improvements led to performing CT scan, which confirmed the diagnosis of SMA syndrome. Subsequently, HP gastritis played a significant role in misleading and delaying the diagnosis.

Conclusion:
The authors report the first case report from Syria of s superior mesenteric artery syndrome that was misdiagnosed and preceded by HP-induced gastritis, highlighting the crucial role of detailed clinical and radiological examinations in the diagnosis of challenging cases with morbid complications.
WITHDRAWN: Multimolecular feature-based machine learning: system biology enhanced RF-QSAR modeling for the efficient prediction of the inhibitory potential of diverse SARS CoV-2 3CL Protease inhibitors
Authors: Manaithiya Ajay , Bhowmik Ratul , Ray Rajarshi , Kumar Sunil , Sharma Sameer , Mathew Bijo , Gong Wenping , Parkkila Seppo , Aspatwar Ashok 
Published: May 2024

Withdrawal StatementThe authors have withdrawn their manuscript owing to the inability to complete the revisions or follow up on the manuscript at this time, due to personal circumstances. Therefore, the authors do not wish this work to be cited as reference for the project. If you have any questions, please contact the corresponding author.