bluuebunny/crossref_metadata_2025_split huggingface dataset:
Genetic and environmental correlates of topiramate‐induced cognitive impairment
Authors: Cirulli Elizabeth T. , Urban Thomas J. , Marino Susan E. , Linney Kristen N. , Birnbaum Angela K. , Depondt Chantal , Attix Deborah K. , Radtke Rodney A. , Goldstein David B. 
Published: November 2011

SummaryTopiramate is an antiepileptic drug that has marked treatment‐limiting side effects on specific aspects of cognitive performance in both patients and healthy volunteers. Because these severe side effects occur only in certain individuals, identifying genetic or environmental variables that influence cognitive response would be of great utility in determining whether to administer this drug to a patient. We gave an acute 100 mg oral dose of topiramate to 158 healthy volunteers and measured how the drug changed their performance on a diverse battery of cognitive tests. We found a wide range of responses to topiramate, and we demonstrated that not all tests in the battery were equally affected. There was no correlation between the effect of topiramate and either education level or baseline cognitive performance. Of interest, there was an up to 55‐fold variation in the topiramate plasma levels of the participants. Our genome‐wide association study (GWAS) of cognitive response did not reveal any genome‐wide significant associations; the study was powered to find variants explaining at least 25% of the variation in cognitive response. Combining the results of this GWAS with a retrospective study of cognitive complaints in 290 epilepsy patients who received topiramate as part of their treatment also did not result in a significant association. Our results support the need for additional genetic studies of topiramate that use larger sample sizes.
Pilot Randomized Trial of Donepezil Hydrochloride for Delirium After Hip Fracture
Authors: Marcantonio Edward R. , Palihnich Kerry , Appleton Paul , Davis Roger B. 
Published: November 2011

ObjectivesTo determine whether donepezil hydrochloride can reduce the prevalence and severity of delirium in older adults undergoing hip fracture repair.DesignPilot double‐masked randomized placebo‐controlled trial.SettingLarge academic medical center.ParticipantsSixteen individuals aged 70 and older with hip fracture.InterventionDonepezil 5 mg or placebo was randomly allocated and initiated within 24 hours of surgery, preoperatively or postoperatively. Daily treatment was continued for 30 days or until side effects or the clinical situation required termination.MeasurementsAll outcomes were ascertained masked to treatment status. Information on drug tolerability and safety was obtained from the participant, nurse, and medical record. Delirium presence and severity were measured during daily hospital interviews and at 2, 4, and 6 weeks after surgery after a standardized assessment using the Confusion Assessment Method (CAM) and the Memorial Delirium Assessment Scale (MDAS).ResultsParticipants in the donepezil and placebo arms had similar baseline characteristics. Participants in the donepezil arm experienced significantly more side effects. In longitudinal models, there were no significant differences between the donepezil and placebo arms with regard to delirium presence over time (odds ratio = 0.9, 95% confidence interval (CI) = 0.4–2.3) or delirium severity over time (effect size = −0.2 on 30‐point MDAS scale, 95%CI = −1.5–1.2).ConclusionParticipants randomized to donepezil had no significant improvement in delirium presence or severity but experienced more side effects. Overall, sufficient evidence was not found from this pilot study to warrant a definitive Phase III trial.
Histomorphometric analysis of sinus augmentation using bovine bone mineral with two different resorbable membranes
Authors: Choi So‐Young , Jang Yoon‐Je , Choi Je‐Yong , Jeong Jae‐Hwan , Kwon Tae‐Geon 
Published: November 2011

AbstractObjectiveThe purpose of this study was to compare the effects of two different resorbable collagen membranes on new bone formation after sinus grafts with anorganic bovine bone mineral (BBM).Materials and methodsFor 64 patients presenting with an initial residual bone height ≤4 mm at the posterior maxilla, the sinus floors were grafted with BBM (Bio‐Oss®). The lateral windows were covered by one of the two bio‐resorbable membranes, Bio‐Arm® or Bio‐Gide®. The histomorphometric data were obtained 7–15 months after sinus augmentation at the time of the implant installation.ResultsThe core biopsy specimens of Bio‐Arm (n = 37 sites) and Bio‐Gide group (n = 22 sites) were compared. The results showed that the BBM particles were in direct contact with the newly formed bone in all cases. In histomorphometric analysis, the Bio‐Gide group showed significantly higher new bone formation (33.3 ± 12%) compared with the Bio‐Arm group (26.3 ± 8.1%) (P < 0.05). All the implants survived successfully after a mean follow‐up of 35.3 months (range 22–63 months) in the Bio‐Arm group and 55.5 months (range 35–66 months) in the Bio‐Gide group. The amount of new bone in the specimens did not significantly correlate with the residual bone height at the time of surgery or the length of the healing period.ConclusionsThe type of resorbable membrane did not readily affect the long‐term survival of the implants at the grafted sinus. On the other hand, Bio‐Gide group showed more new bone formation than the Bio‐Arm group, which implied that the function of the membrane can influence the remodeling of the grafted sinus. As the amount of residual bone substitute particle had not decreased significantly over time, the results suggest that the BBM was rarely resorbable for at least 15 months after the surgery.
Dynamic analysis for mental sweating of a group of eccrine sweat glands on a human fingertip by optical coherence tomography
Authors: Ohmi Masato , Tanigawa Motomu , Wada Yuki , Haruna Masamitsu 
Published: November 2011

BackgroundAn important function of skin physiology is mental sweating, where sweating is accelerated via the sympathetic nerve by mental or physical stress externally applied to a volunteer.AimActivity of the sympathetic nerve (ASN) is evaluated by quantitative measurement of mental sweating.Material and MethodsOptical coherence tomography (OCT) is highly potential for in vivo observation of human sweating dynamics which affects ASN. We demonstrate dynamic OCT analysis of mental sweating of a group of eccrine sweat glands. The sweating dynamics is tracked simultaneously for 19 sweat glands by time‐sequential piled‐up en‐face OCT images with the frame spacing of 3.3 s. The en‐face OCT images of the spiral lumen of the eccrine sweat gland are constructed by data acquisition of the 128 B‐mode OCT images.ResultsIt is thus found that the response to mental stress is different for each sweat gland even though the sweat glands are adjacent to each other. Such strong non‐uniformity is observed in mental sweating where the amount of excess sweat is different for each sweat gland although the sweat glands are adjacent to each other.DiscussionThe non‐uniformity should be necessary to adjust as precisely the total amount of excess sweat as possible through the sympathetic nerve in response to strength of the stress.
Fracture susceptibility of endodontically treated teeth
Authors: Zamin Caroline , Silva‐Sousa Yara Terezinha Correa , Souza‐Gabriel Aline Evangelista , Messias Danielle Furtado , Sousa‐Neto Manoel Damião 
Published: November 2011

Abstract –  Aim:  To assess the influence of cervical preparation on fracture susceptibility of roots.Material and methods:  During root canal instrumentation, the cervical portions were prepared with different taper instruments: I: no cervical preparation; II: #30/.08; III: #30/.10; IV: #70/.12. The specimens were sealed with the following filling materials (n = 8), A: unfilled; B: Endofill/gutta‐percha; C: AH Plus/gutta‐percha; D: Epiphany SE/Resilon. For the fracture resistance test, a universal testing machine was used at 1 mm per minute.Results:  anova demonstrated difference (P < 0.05) between taper instruments with a higher value for group I (205.3 ± 77.5 N) followed by II (185.2 ± 70.8 N), III (164.8 ± 48.9 N), and IV (156.7 ± 41.4 N). There was no difference (P > 0.05) between filling materials A (189.1 ± 66.3 N), B (186.3 ± 61.0 N), C (159.7 ± 69.9 N), and D (176.9 ± 55.2 N).Conclusions:  Greater cervical wear using a #70/.12 file increased the root fracture susceptibility, and the tested filling materials were not able to restore resistance.
Identification and characterization of novel spliced variants of PRMT2 in breast carcinoma
Authors: Zhong Jing , Cao Ren‐Xian , Zu Xu‐Yu , Hong Tao , Yang Jing , Liu Ling , Xiao Xin‐Hua , Ding Wen‐Jun , Zhao Qiang , Liu Jiang‐Hua , Wen Ge‐Bo 
Published: November 2011

Protein N‐arginine methyltransferases (PRMTs) participate in a number of cellular processes, including cell growth, nuclear/cytoplasmic protein shuttling, differentiation, RNA splicing and post‐transcriptional regulation. PRMT2 (also known as HRMT1L1) is clearly involved in lung function, the inflammatory response, apoptosis promotion, Wnt signaling and leptin signaling regulation through different mechanisms. In this study, we report the molecular and cell biological characterization of three novel PRMT2 splice variants isolated from breast cancer cells and referred to as PRMT2α, PRMT2β and PRMT2γ. Compared with the wild‐type PRMT2, these variants lack different motifs and therefore generate distinct C‐terminal domains. Confocal microscopy scanning revealed a distinct intracellular localization of PRMT2 variants, suggesting that the alternatively spliced C‐terminus of PRMT2 can directly influence its subcellular localization. Our findings reveal that these variants are capable of binding to estrogen receptor alpha (ERα) both in vitro and in vivo, and the N‐terminal regions of these variants contribute to ERα–PRMT2 interactions. Furthermore, these variants were proved to be able to enhance ERα‐mediated transactivation activity. Luciferase reporter assays showed that PRMT2s could modulate promoter activities of the ERα‐targeted genes of Snail and E‐cadherin. In addition, PRMT2 silencing could enhance 17β‐estradiol‐induced proliferation by regulating E2F1 expression and E2F1‐responsive genes in ERα‐positive breast cancer cells. Real‐time PCR and immunohistochemistry showed that overall PRMT2 expression was upregulated in breast cancer tissues and significantly associated with ERα positivity status both in breast cancer cell lines and breast cancer tissues. We speculate that PRMT2 and its splice variants may directly modulate ERα signaling and play a role in the progression of breast cancer.Structured digital abstract
PRMT2 and AR colocalize by fluorescence microscopy (View interaction)
PRMT2 physically interacts with AR by anti tag coimmunoprecipitation (View interaction)
PRMT2 physically interacts with ER‐alpha by anti tag coimmunoprecipitation (View interaction)
PRMT2 binds to ER‐alpha by pull down (View interaction)
PRMT2 physically interacts with ER‐alpha by pull down (View interaction)
ER‐alpha and PRMT2 colocalize by fluorescence microscopy (View interaction)
DEVELOPMENT AND QUALITY EVALUATION OF HIGH‐PROTEIN AND HIGH‐DIETARY‐FIBER PASTA USING LUPIN FLOUR
Authors: JAYASENA VIJAY , NASAR‐ABBAS SYED M. 
Published: November 2011

ABSTRACTPasta samples were prepared by substituting semolina with lupin flour at 0–50% levels. Analysis of the physical properties revealed that cooking loss was not affected by lupin flour incorporation. In dried pasta, the color coordinates L*, a* and b* demonstrated a corresponding increase with lupin flour concentration. However, in cooked pasta, L* and b* values did not show any significant change up to 20% lupin flour incorporation.Lupin flour incorporation resulted in substantial increase in protein and dietary fiber contents. Firmness of freshly extruded pasta decreased at ≥20% lupin flour incorporation. However, firmness of cooked pasta was not affected by lupin flour concentration. Stickiness of cooked pasta decreased at ≥30% lupin flour incorporation.There were no significant changes in color, appearance, taste, texture and overall acceptability up to 20% lupin flour incorporation. It can be concluded that nutritional value of pasta can be improved by lupin flour incorporation without any significant effect on quality.PRACTICAL APPLICATIONSLupin grain has a unique nutritional composition with high protein and high dietary fiber contents. Lupin flour incorporation would improve the nutritional value of pasta, which is otherwise low in protein and dietary fiber contents. The current study provides the technical information on the effect of lupin flour incorporation on a range of physical properties of pasta at various stages such as freshly extruded pasta, dried pasta and cooked pasta. The information will be useful in handling, packaging and processing of lupin‐incorporated high‐protein and high‐dietary‐fiber pasta at commercial levels, and developing new machinery or adjusting currently used pasta machinery for this novel healthy pasta production.
MICROSCOPY AND TEXTURE OF RAW AND COOKED CASSAVA (MANIHOT ESCULENTA CRANTZ) ROOTS
Authors: MAIEVES HELAYNE APARECIDA , OLIVEIRA DAIANA CARDOSO DE , BERNARDO CLAUDIA , MÜLLER CARMEN MARIA DE OLIVEIRA , AMANTE EDNA REGINA 
Published: November 2011

ABSTRACTInformation regarding the behavior of starchy roots can be an important factor to define the best cultivars in agricultural aspects besides their application either as uncooked or cooked raw material in food industries. The main goal of this work was to show the relationship between the microscopic characteristics and the hardness of raw and of cooked cassava roots in order to suggest their use in different industrial sectors that produce cassava derivatives. Scanning electron microscopy (SEM) was used to define the causes of the differences in cooking time and in hardness of the roots studied. SEM, in conjunction with texture evaluation, can discriminate the roots that are ideal for specific industrial applications. Also, information on their agricultural yield and physical and physicochemical properties can help determine the best cultivars for other industrial applications.PRACTICAL APPLICATIONSThe agricultural performance of plants for industrial uses should be preceded by rheological characteristics in order to predict the behavior a certain raw material will have when cooked, gridded or submitted to either chemical or enzymatic processes. This work suggests some relationship regarding the tendency for hardness and for softness of 10 different cassava cultivars in relation to their microscopic characteristics and starch and fiber contents. According to these variables, it is possible to establish the best starchy raw material for specific uses.
CONSUMERS' TEXTURE PERCEPTION OF MILK DESSERTS. II – COMPARISON WITH TRAINED ASSESSORS' DATA
Authors: BRUZZONE FERNANDA , ARES GASTÓN , GIMÉNEZ ANA 
Published: November 2011

ABSTRACTConsidering the importance of texture in consumers' acceptance of many dairy products, particularly milk desserts, it is important to rely on methodologies to understand consumers' texture perception. The aim of the present work was to study the relationship between consumers' texture perception of milk desserts and trained assessors' data.Six commercial milk desserts were evaluated by a panel of 100 consumers, divided into two groups of 50, which evaluated the texture of the desserts using intensity scales for five texture attributes or a check‐all‐that‐apply question. Concurrently, seven texture attributes of the desserts were evaluated by a trained panel.Results showed that both consumer profiling methodologies were able to identify differences in the texture characteristics of the desserts, providing very similar sensory maps. High correlation between textural attributes evaluated by consumers and trained assessors was found, indicating that consumers were able to evaluate the attributes in a similar way as trained assessors did.PRACTICAL APPLICATIONSIntensity scales and check‐all‐that‐apply (CATA) question seemed to be good alternatives to the use of trained assessors' panels when evaluating consumers' texture perception. Although both methodologies provided similar information, CATA questions would be preferred over intensity scales for being easier because consumers only have to check the terms from the question that are considered appropriate for each sample, getting rid of the need of asking consumers to score the intensity of sensory attributes using scales.The application of consumer profiling methodologies has the advantage of being based on consumers' perception of the products. However, it is important to highlight that these methodologies should be considered complementary to trained assessors data and that they might be particularly recommended for those food companies that do not enough time nor resources to train a panel for a specific application.
Four‐year successive rearing of Glyptotendipes tokunagai Sasa (Diptera: Chironomidae) under laboratory condition
Authors: Baek Min Jeong , Yoon Tae Joong , Hwang Jeong Mi , Kang Hyo Jeong , Lee Song Ji , Cho Kijong , Bae Yeon Jae 
Published: November 2011

The dipteran Chironomidae have been commonly used as water quality indicators and toxicity test organisms. Two chironomids, Chironomus riparius Meigan and C. tentans Fabricius, are standard test organisms for toxicity (OECD), but their distribution is limited in Korea. The purpose of this study was to establish a Korean native chironomid species as a toxicity test organism. Glyptotendipes tokunagai Sasa, distributed widely in Korean streams, was selected and reared successively under laboratory conditions for over 30 generations over 4 years.Four G. tokunagai egg masses were collected from the Jungrang stream in Seoul, Korea in April 2007 and introduced to the laboratory for rearing. Room temperature (23.5 ± 3.2°C), larval and adult rearing cages, mating cages, and larval food were appropriately modified from conventional chironomid rearing methods. The number of eggs in an egg mass, hatching rate, and adult body sizes (head width, thorax width, wing width and length, and body length) were monitored every generation.As a result, the number of eggs in an egg mass decreased rapidly in early generations, and then tended to stabilize after the fourth generation (p < 0.05). The mean hatching rate was higher than 75% in all generations. The gender ratio (no. of females/total no. of adults) was 0.24–0.52. The adult body size became significantly reduced in the initial three generations and tended to be stabilized in the following generations (p < 0.05), although it depended on food supply and larval density. This is the first case of chironomid domestication in Korea that has been successfully reared longer than 4 years under laboratory conditions. This reared population of G. tokunagai can be used for various environmental studies such as bioassays, ecological risk assessments, and environmental monitoring.
Urban conflict by social wasps in Seoul
Authors: Choi Moon‐Bo , Kim Jeong‐Kyu , Lee Jong‐Wook 
Published: November 2011

This study conducted an investigation on the damage by social wasps within the metropolis of Seoul and Busan of Korea. Damage by social wasps in Seoul has increased 5.5 times with total 12,406 cases in the past ten years. Damages were arisen from July to September the most at the outskirts of a city near mountains and continuously increased within the internal area of city. Social wasps turned out to inhabit open spaces such as eaves, window frame and garden among 49 nesting places and Polistes rothneyi koreanus were most frequently found of all species.As the final outcome, increase of green space within the urban area, stability of nesting place, city temperature, stability against natural enemy, influence of media are believed to be the reasons of increase of social wasps within the city.
New Record of the Coastal Species, Heterota onorum Maruyama in Korea (Coleoptera: Staphylinidae: Aleocharinae)
Authors: Yoo In‐Seong , Kim Yoon‐Ho , Ahn Kee‐Jeong 
Published: November 2011

While collecting the Korean seashore Staphylinidae, we found unusual rove beetles under decaying seaweeds along beaches of the southern coasts. As a result of the detailed study of them, we identified them as Heterota onorum Maruyama, new to Korean fauna.Heterota Mulsant and Rey contains 11 species worldwide and one species (H. sunjaei) in Korea, all members of which are confined to coastal habitat and usually found under decaying seaweeds on rocky shore or sandy beach. The genus can be recognized by the combination of following characters: broad occiput; prominent eyes; narrow and long ligula; labial palpi with two articles; transverse pronotum; tarsal formula 4‐4‐5.In this study, we present a habitus photographs, diagnosis, illustrations of diagnostic characters, and distributional map of the species.
Taxonomic Review of Korean Hedychrum Latreille, with a description of new species
Authors: Ha Hyeong‐Hwa , Kim Jeong‐Kyu 
Published: November 2011

The genus Hedychrum Latreille is the second largest one of the tribe Elampini (Chrysidinae: Chrysididae), with 146 extant species mainly distributed in Eastern Hemisphere. Almost entire species of the genus were known to be the cleptoparasites ofsphecid subfamily Philanthinae (Kimsey and Bohart, 1990).The members of Hedychrum are small to medium‐sized chrysidid wasps ranging from 3.5 mm to 8.5 mm in body length, and separated from other generic members by the following combination of characteristics. Scapal basin somewhat deeply excavated and compactly cross‐ridged, presence of a sharp tooth on base of oral fossa, presence of anteromedial pit on pronotum, rounded mesopleuron with indistinct omaulus and short scrobal sulcus, lacking of medial enclosure on propodeum, presence (sometimes obsolete) of pit or depression in mid and hind tibial inner faces, enlarged hind femur, tarsal claw with sub‐parallel tooth (appearing apically bifid), forewing medial vein very slightly curved (almost straight), stigma slender and apically acute, tergum III usually with lateral tooth and sub‐apically swollen, female sternum III with sub‐basal sulcus extending toward mid‐line and often with apicomedial tubercle.So far, taxonomic information on KoreanHedychrum has been fragmentary and secondary in previous regional‐based studies (Uchida, 1927; Tsuneki, 1953; Terayama et al., 2005) that providedjust outline of the occurrence of four species.We reviewed the genus Hedychrumin Korea, and confirmed six species including four previously known ones. Among them, Hedychrumkoreanum Ha and Kim is here supposed to be new to science, and H. chalybaeumis new to Korea. The new species is very similar to H. okai, but easily separated by the presence of carinae on ventrolateral face of fore‐femur and difference in coloration. Key, description, additional diagnosis, and digital images are provided.