bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effective treatment for fatty liver of liraglutide via inhibiting endoplasmic reticulum stress, oxidative stress and apoptosis pathways
Authors: Li Juan , Xu Jiaxin , Zhu Fangfang , Wang Chun 
Published: May 2024

IntroductionFatty liver disease (FLD) is a frequent medical condition marked by hepatic adipose tissue accumulation. It may cause liver damage in certain cases. This study examined liraglutide’s inhibition of FLD and its molecular mechanism.Material and methodsGSE63067 was downloaded from the Gene Expression Omnibus (GEO) database. The analysis of differentially expressed genes (DEGs) was performed using the Limma package. Enrichment analysis was performed. The Sprague-Dawley (SD) rats were fed a high-fat diet to develop FLD, then administered liraglutide. Serum lipid levels were tested by ELISA, and pathological sections were used for oil red O staining. In in vitro experiments, the hepatic cells were stimulated with free fatty acids (FFAs), liraglutide, and tunicamycin. Immunofluorescence double staining and western blot testing were carried out.ResultsEnrichment analysis showed that DEGs were enriched in endoplasmic reticulum (ER) stress, oxidative stress, and apoptosis pathways. Liraglutide treatment reduced the expression of p-PERK and CHOP resulting from FFAs. Western blot assessment revealed that liraglutide treatment reduced the expression of GRP78, GRP94, p-PERK, p-IRE1, ATF6, and CHOP resulting from FFAs but not the expression of these proteins resulting from FFAs and tunicamycin. Flow cytometry revealed that liraglutide treatment reduced SD rat liver cell apoptosis resulting from FFAs. Liraglutide treatment decreased the expression of cleaved caspase-3, caspase-9, caspase-12, and Bax resulting from FFAs.ConclusionsLiraglutide exerts a therapeutic effect in the context of FLD through its ability to suppress endoplasmic reticulum stress (ERS) and inhibit apoptosis of hepatic cells.
The role of upper-ocean heat content in the regional variability of Arctic sea ice at sub-seasonal timescales
Authors: Bianco Elena , Iovino Doroteaciro , Masina Simona , Materia Stefano , Ruggieri Paolo 
Published: May 2024

Abstract. In recent decades, the Arctic Ocean has undergone changes associated with enhanced poleward inflow of Atlantic and Pacific waters and increased heat flux exchange with the atmosphere in seasonally ice-free regions. The associated changes in upper-ocean heat content can alter the exchange of energy at the ocean–ice interface. Yet, the role of ocean heat content in modulating Arctic sea ice variability at sub-seasonal timescales is still poorly documented. We analyze ocean heat transports and surface heat fluxes between 1980–2021 using two eddy-permitting global ocean reanalyses, C-GLORSv5 and ORAS5, to assess the surface energy budget of the Arctic Ocean and its regional seas. We then assess the role of upper-ocean heat content, computed in the surface mixed layer (Qml) and in the 0–300 m layer (Q300), as a sub-seasonal precursor of sea ice variability by means of lag correlations. Our results reveal that in the Pacific Arctic regions, sea ice variability in autumn is linked with Qml anomalies leading by 1 to 3 months, and this relationship has strengthened in the Laptev and East Siberian seas during 2001–2021 relative to 1980–2000, primarily due to reduced surface heat loss since the mid-2000s. Q300 anomalies act as a precursor for wintertime sea ice variability in the Barents and Kara seas, with considerable strengthening and expansion of this link from 1980–2000 and 2001–2021 in both reanalyses. Our results highlight the role played by upper-ocean heat content in modulating the interannual variability of Arctic sea ice at sub-seasonal timescales. Heat stored in the ocean has important implications for the predictability of sea ice, calling for improvements in forecast initialization and a focus upon regional predictions in the Arctic region.
Older Humans and Their Dogs
Authors: Bartram Angela 
Published: May 2024

Loneliness and a lack of socialization can have a deteriorating effect on life experience and health. Unfortunately, loneliness is an experience often felt by older people, and interspecies companionship can provide valuable and daily interaction that is positive for well-being. In the place of another human, a dog may inhabit a role as a provider of emotional support.
In Judith Butler’s sense of performative identity, there is a becoming of that which we do. Using an approach of working with (rather than on) people, this informs sensitive and sympathetic methodologies for an analysis of the significance and benefit of interspecies companionship for older people in the initial stages of my artistic research project, Dogs and the Elderly. Made with participants of the Alzheimer’s Society’s “Memory Cafés” in Nottingham and Lincolnshire (UK), the project demonstrates how interspecies companionship can be valuable for supporting the emotional health and wellbeing of older people. This illustrated photo and text article discusses how the project’s older humans and their dogs inhabit a togetherness within supportive interspecies relationships in various ways, and how this contributes to their lived experience. It explores the stories of a group of people, living with or supporting others with early-stage Alzheimer’s, who speak to companionship with their dogs to articulate the significance of the relationship from their perspective.
Demographic Differences among Internalizing Stigmatization, Marital Satisfaction, and Spousal Support Received by Depressive Patients
Authors: Azam Muhammad , Ahmed Muhammad Irfan , Mushtaque Iqra , Haq Inam Ul , Moazim Ali Muhammad 
Published: May 2024

Background: There are surprising benefits to being married. Married people have lower stress and are less likely to be depressed. However, depression is not an exemption for married people. In Pakistani society, people undergoing depression are stigmatized as mentally ill. The ideal marriage is supposed to have a good understanding and friendly relationship. Objective: So, the effect of spousal support received by diagnosed depression patients and the level of marital satisfaction attained by a socially stigmatized spouse is the subject of this study. Methods: This is a cross-sectional study. Purposive sampling was used to collect data from 240 individuals. After obtaining informed consent, responses were taken on internalized stigma of mental illness scale, couple satisfaction index, and spousal support scale, respectively. Descriptive and t-test analysis were used to analyze the data through SPSS. Results: The results revealed significant gender differences on the scale of internalizing stigma of mental illness. Depressed husbands showed lower marital satisfaction despite getting more support from their spouses.In contrast, depressed women seem to be satisfied as compared to men. Although demographic variables like love marriage, arrange marriage, the family system had a more significant impact on marital satisfaction and spousal support. Conclusion: This study finding provides information for the therapist can work in areas of depressed married individuals that Internalized stigma affects the quality of life, self-esteem, and sense of well-being that is indispensable to marital satisfaction.
Comparing the Outcomes of Titanium and Stainless Steel Flexible Nails in Repairing Pediatric Long Bone Fractures
Authors: Zamzam Mazen , Bopari Novelpreet , Arapovic Avianna , Kamel-ElSayed Suzan , Saleh Ehab S. 
Published: May 2024

Background Traditionally, pediatric femoral fracture treatment favored conservative methods, relying on casting and the inherent bone remodeling ability in immature bones. Surgical intervention was deferred until age 6, as nonoperative approaches often resulted in complications. Titanium elastic nailing (TENS) emerged as an effective treatment for diaphyseal femoral fractures in ages 6 to 16. However, the choice between TENS and stainless steel elastic nailing (SSENS) remains debated due to inconsistent findings. Objective This study aimed to evaluate the effectiveness of both nailing systems in pediatric long bone fractures. Methods A retrospective chart review at William Beaumont Hospital Royal Oak included 83 patients aged 6 to 16 treated with TENS or SSENS between January 2011 and January 2021. Data collected encompassed nail related issues, time to fracture union, full weight bearing, and nail removal. Results In the TENS group (n=29), the average age was 8.8±2.4 years, and the average BMI was 17.2±3.4. The SSENS group (n=54) had an average age of 9.3±2.7 and an average BMI of 19.7±8.4. Time to fracture union for TENS was 93.8±60.5 days, while SSENS was 82.2±40.0 days. Conclusion This study found no statistically significant differences in nail-related complications, time to fracture union, full weight bearing, or nail removal between TENS and SSENS in pediatric long bone fractures. The choice between these systems should be based on individual circumstances. Limitations include a small sample size and the study’s retrospective nature.
Emotional - Behavioral Difficulties and Prosocial Behaviour among Vietnamese Adolescents: the Role of Social Support
Authors: Thi Thuy Nguyen 
Published: May 2024

Background In recent decades, a high prevalence of mental health problems among adolescents has been reported worldwide. In Vietnam, mental health problems such as emotional and behavioural difficulties are relatively common in the adolescent age group. Objective This study aimed to estimate the prevalence of emotional-behavioural problems and prosocial behaviours in Vietnamese adolescents and identify the role of social support in these adolescents’ strengths and difficulties. Methods A population sample of 582 adolescents from sixth to ninth grade from four secondary schools in Vietnam voluntarily participated by completing the Strengths and Difficulties Questionnaire (α = .64) and the Social Support Scale (α = .90). Results The research results revealed that Vietnamese adolescents suffered from considerable levels of emotional-behavioural difficulties and prosocial behaviour problems. Through multible regression analysis, support from their families significantly predicted to decrease students’ emotional and behavioural symptoms (β< 0; p< .05) and increasing prosocial behaviours (β> 0; p < .05). In contrast, friend support only contribute to protecting adolescents from behavioural problems (β = -.18; p < .05) and encouraged prosocial behaviours (β = .22; p < .05) Discussion Family support had a central role in its positive contribution to reducing emotional-behavioural and prosocial behaviour problems. Friend support only decreased behavioural problems and encouraged prosocial behaviours. These results are interpreted that educators could limit adolescents’ emotional-behavioural difficulties and encourage prosocial behaviours through social support from their families and friends.
Analysis of Internal Control Systems for Merchandise Inventory in Minimizing Damage and Loss of Merchandise at the Indomaret Minimarket in Surabaya, Bengkulu City
Authors: Prasetya Andika Dwi Yudha , Susanti Neri , Noviantoro Rinto 
Published: May 2024

Accounting Information System. The formulation of the problem in this study is how the internal control system for merchandise inventory minimizes damage and loss of merchandise at the Indomaret Minimarket Surabaya Bengkulu City. The purpose of this study was to determine the internal control system for merchandise inventory at the Indomaret Minimarket Surabaya Bengkulu City.

This type of research is descriptive research. The research method used is descriptive qualitative method. Data collection was carried out by means of interviews and documentation. Sources of data used primary data and secondary data. The results of this study are that the internal control system for merchandise inventory at the Indomaret Minimarket Surabaya Bengkulu City has not been implemented properly because there is still no warehouse function. Effective measures to minimize damage and loss of merchandise and maintain inventory levels have not been implemented properly.
The Effects Of Transformational Leadership And Organizational Culture On Employee's Performance (Case Study at Nippon Paint Company Branch in Bengkulu City)
Authors: Agustina Mia Tri , Irwanto Tito , Prima Monique D Eska 
Published: May 2024

This study aims to determine the calculation and effect of leadership and organizational culture on employee’s performance at Nippon Paint company branch in Bengkulu City. The analytical method used in the research is the quantitative method. Based on research results, Transformational Leadership has a significant effect on Employee’s Performance because tcount (2.753) is greater than ttable (1.674) with a significant value of 0.008 < 0.05. This illustrates that the better the transformational leadership at Nippon Paint company branch in Bengkulu City, the more employee’s performance will increase. Organizational culture does not have a significant effect on employee’s performance because tcount (0.771) is smaller than ttable (1.674) with a significant value of 0.445 > 0.005. This illustrates that employees at Nippon Paint company branch in Bengkulu City. From the simultaneous test results we can see that there is a significant effect between transformational leadership and organizational culture on the employee’s performance at Nippon Paint company branch in Bengkulu City together because the value of Fcount > Ftable is 4.581 > 3.18 with a significance of 0.015 < 0, 05. From the results of the coefficient of determination test, the R square value is 0.155 or 15.5%. It can be concluded that there is a variable effect on employee’s performance of 15.5%. The remaining 84.5% is effected by variables outside this research.
Positive Deviance and Exploring the Role of Mental Health on Early Postoperative Recovery After Total Hip Arthroplasty: A Retrospective Analysis Using the PROMIS-10 Global Health
Authors: Kostyun Regina O. , Hackett Anna , Lucchio Peter , Witmer Daniel K. , Solomito Matthew J. 
Published: May 2024

Introduction:
Mental illnesses are well-known factors that contribute to poor outcomes among total hip arthroplasty (THA) patients. However, a dichotomized mental illness diagnosis may not reflect the complex biopsychosocial factors contributing to a patient's health. Investigating patients who achieve positive outcomes despite having risk factors, known as positive deviants, may help identify protective characteristics and decrease health disparities among this growing population of patients. Using preoperative Mental Health T-scores (MHT) from the PROMIS-10 Global Health questionnaire among patients with a mental illness diagnosis, the purpose of this study was to explore whether patients with above-average MHT, or positive deviants, experienced a different immediate postoperative recovery path compared with patients with below-average MHT.

Methods:
This was a retrospective chart review of patients undergoing elective primary THA. Patients with a formal diagnosis of a mental health condition were divided based on their MHT (above average [AA] >50, average [A] 40 to 50, below average [BA] <40). Postsurgical parameters included total opioid consumption, self-reported pain scores, and discharge disposition.

Results:
A total of 299 patients were analyzed. After controlling for length of stay and type of mental illness, patients in the AA-MHT and A-MHT groups used 33.8 and 29.8 morphine milligram equivalents less than patients in the BA-MHT group during the inpatient stay, respectively. Patients in the AA-MHT group reported a 1.0 lower pain with activity score at discharge compared with patients in the BA-MHT group.

Discussion:
The intersection between patients with a mental illness in need of a THA is becoming more commonplace. Data suggest that patients with a mental illness who report AA-MHT on the PROMIS-10 Global Health questionnaire may represent positive deviants or those with a more positive in-hospital recovery path compared with those patients with BA-MHT.

Level of evidence:
Diagnostic study–retrospective cohort study.
Study on the Properties of Waste Stone Powder-clay Slurry based on the Influence of Filter Press
Authors: Chen Xinming , Chen Jiaojiao , Jiao Huazhe , Li Dongbing , Yang Zhi , Wang Jie 
Published: May 2024

A grouting material pressure effect simulation device (FSD) was used to study the performance of grout considering grouting pressure, slurry rheology, clay ash, slurry concentration and particle size composition of waste stone powder (FSD influencing factors). After the effect of filter pressing, the alkaline environment of the slurry became stronger, the number of active particles increased, and the CaCO3 and clay crystals were fully agglomerate, and the degree of crystallization increased. The cation exchange capacity increased, and the formation of calcium-silicon-aluminum matrix phase and aluminosilicate aggregates increased. The surface water between the matrix particles supports the crystal layer, and the plastic viscosity and yield stress are reduced. The free calcium oxide decreased, and the consolidation shrinkage rate after slurry hardening was less than 1%. The water-cement ratio is reduced, and the total time for slurry to be poured into the fracture to consolidate and form a mold and intermittent is shortened. The use of waste stone powder and clay in the coal mine grouting industry can not only reduce project costs, but also reduce soil erosion and soil pollution.
Análise sensorial e aceitabilidade de consumidores de pirarucu (Arapaima Gigas) provenientes da reserva de desenvolvimento
Authors: Benitz Tabatha , Pires Felipe Jacob , Monteiro Sabrina Sauthier , Gomes Maria Cecilia Rosinski Lima , Barros Ana Paula Campos , Gonçalves Ana Cláudia Torres 
Published: May 2024

Introdução e Objetivo: A análise sensorial destaca-se na avaliação da qualidade e estabilidade de diversos produtos porque nenhum teste instrumental ou químico pode substituir os receptores sensoriais. O objetivo do trabalho foi realizar uma análise sensorial com o pirarucu da região de Mamirauá (Coari e Jurupari) para investigar a aceitabilidade do peixe pelo consumidor. Metodologia: Foi realizada a investigação dos micro-organismos no Laboratório de Microbiologia do Instituto de Desenvolvimento Sustentável Mamirauá para certificação da sanidade dos produtos expostos aos provadores e equipe da análise sensorial por meio de contagens de bactérias heterotróficas aeróbias mesófilas e pscicrotróficas de acordo com a Instrução Normativa nº 62 de 26 de agosto de 2003. Resultados: Na análise sensorial o painel de 55 consumidores mostrou aceitabilidade das amostras com valores para todos os atributos superiores a 70%. A amostra de Manejo de Coari ficou 6% acima da amostra de Manejo de Jurupari na escala “Decididamente compraria”. Conclusão: O estudo mostrou que por meio da análise sensorial foi possível detectar que o pirarucu de ambas as regiões apresentou atributos como cor, odor, textura e sabor bem aceitos destacando que os provadores gostaram das amostras apresentadas.
Política nacional de atenção integral à saúde das pessoas privadas de liberdade no sistema prisional (PNAISP): uma revisão sistemática da literatura
Authors: Pereira Cayon Felipe Peres Aidar , Santos Francilaine Ferreira dos , Sodre Laisa Ferreira , Galante Paulo Roberto Rezende , Tavares Bárbara Peréa , Oliveira Tathiane Souza de , Piffer Douglas Moro 
Published: May 2024

A saúde no sistema prisional brasileiro é um grave problema de saúde pública, evidenciado pela superlotação, falta de insumos básicos e violência, exigindo urgente atenção das autoridades. A despeito da PNAISP representar um avanço significativo na garantia do direito à saúde dos detentos, em consonância com os princípios de universalidade e equidade, no sistema prisional de Porto Velho, a superlotação, que reflete uma realidade nacional de escassez de vagas e dificuldades na efetiva ressocialização dos detentos, evidencia a necessidade de uma abordagem mais abrangente e sensível às questões de saúde e bem-estar dos presos. Objetivo: Propõe-se a examinar como a PNAISP influencia a saúde dos detentos no contexto brasileiro. Materiais e Métodos: Para atingir os propósitos do estudo, optou-se por uma abordagem metodológica que mesclou a revisão sistemática da literatura com uma análise minuciosa do conteúdo dos estudos selecionados, buscando identificar padrões emergentes, desafios enfrentados e os impactos na saúde dos detentos após a implementação da PNAISP. Resultados: Foram analisadas 5 publicações que atenderam aos critérios de inclusão e exclusão do método de análise de pesquisa bibliográfica sistematizada, cujos principais achados foram: Estratégias de Saúde Física e Notificação de Doenças; Controle e Prevenção de Doenças Infecciosas; Adaptação das Políticas de Saúde às Necessidades Específicas da Instituição; Atividades de Promoção da Saúde Mental e Ressignificação de Vidas; e Participação Comunitária e Controle Social. Considerações finais: As análises evidenciam a complexidade das estratégias de saúde no contexto prisional, destacando a importância de considerar não apenas o acesso aos serviços médicos, mas também aspectos mais amplos relacionados ao contexto social, cultural e emocional das pessoas envolvidas.
Reciclagem de pneus para utilização na fabricação de concreto estrutural
Authors: Britto Shirlei de Souza , Sirqueira Alex da Silva 
Published: May 2024

O descarte de pneus inservíveis no meio ambiente gera um enorme problema ambiental. O aproveitamento destes resíduos na formulação de concreto tem despertado crescente interesse nas últimas décadas, representando uma abordagem inovadora e sustentável para lidar com este problema mundial, auxiliando inclusive na logística reversa, contribuindo para soluções economicamente viáveis para atender a lei nº 12.305/10 referente à Política Nacional de Resíduos Sólidos (PNRS) e à Resolução CONAMA nº 416/09 do IBAMA que dispõe sobre as diretrizes relativas à gestão integrada e ao gerenciamento de resíduos sólidos. O objetivo deste estudo é realizar um levantamento bibliográfico a fim de se obter dados com a incorporação de resíduos de borracha na confecção de concreto, de modo a entender como essa modificação no compósito pode modificar suas propriedades mecânicas e verificar se é possível obter resultados satisfatórios com diferentes percentuais e adição ou substituição de materiais, garantindo um desempenho tal que essa alteração não afete os limites de norma. Os experimentos apresentados mostram dados como variação nas propriedades mais importantes do concreto: resistência à compressão e módulo de elasticidade. As correlações mostraram a importância de se escolher um bom traço para elaboração do concreto, determinar de forma correta e eficiente a relação água cimento e principalmente o percentual adequado de adição/ substituição do resíduo de borracha na massa de agregados miúdos.