bluuebunny/crossref_metadata_2025_split huggingface dataset:
Design of ANCHOR-RA: a multi-national cross-sectional study on screening for interstitial lung disease in patients with rheumatoid arthritis
Authors: Sparks Jeffrey A. , Dieudé Philippe , Hoffmann-Vold Anna-Maria , Burmester Gerd R , Walsh Simon LF , Kreuter Michael , Stock Christian , Sambevski Steven , Alves Margarida , Emery Paul 
Published: May 2024

Abstract
Background
Patients with rheumatoid arthritis (RA) are at risk of developing interstitial lung disease (ILD), which is associated with high mortality. Screening tools based on risk factors are needed to decide which patients with RA should be screened for ILD using high-resolution computed tomography (HRCT). The ANCHOR-RA study is a multi-national cross-sectional study that will develop a multivariable model for prediction of RA-ILD, which can be used to inform screening for RA-ILD in clinical practice.

Methods
Investigators will enrol consecutive patients with RA who have ≥ 2 of the following risk factors for RA-ILD: male; current or previous smoker; age ≥ 60 years at RA diagnosis; high-positive rheumatoid factor and/or anti-cyclic citrullinated peptide (titre > 3 x upper limit of normal); presence or history of certain extra-articular manifestations of RA (vasculitis, Felty’s syndrome, secondary Sjögren’s syndrome, cutaneous rheumatoid nodules, serositis, and/or scleritis/uveitis); high RA disease activity in the prior 12 months. Patients previously identified as having ILD, or who have had a CT scan in the prior 2 years, will not be eligible. Participants will undergo an HRCT scan at their local site, which will be assessed centrally by two expert radiologists. Data will be collected prospectively on demographic and RA-related characteristics, patient-reported outcomes, comorbidities and pulmonary function. The primary outcomes will be the development of a probability score for RA-ILD, based on a multivariable model incorporating potential risk factors commonly assessed in clinical practice, and an estimate of the prevalence of RA-ILD in the study population. It is planned that 1200 participants will be enrolled at approximately 30 sites in the USA, UK, Germany, France, Italy, Spain.

Discussion
Data from the ANCHOR-RA study will add to the body of evidence to support recommendations for screening for RA-ILD to improve detection of this important complication of RA and enable early intervention.

Trial registration
clinicaltrials.gov NCT05855109 (submission date: 3 May 2023).
Psychiatric impact of the novel coronavirus disease 2019 on previously mentally healthy survivors
Authors: Naguib Rehab Mohamed , Amin Ghada Refaat , Serafi Doha El , Naga Hend Adel Hamed , Sallam Sara Ashraf 
Published: May 2024

Abstract
Background
The prolonged psychiatric disorders rate following coronavirus disease 2019 (COVID-19) could surpass that of severe acute respiratory syndrome (SARS) as well as Middle East Respiratory Syndrome (MERS) as a result of variations in viral disease treatment as well as societal circumstances throughout the outbreaks. This work aimed to investigate the COVID-19 prolonged psychiatric effects on survivors without psychiatric diseases before infection.

Methods
This cross-sectional research was conducted on 1254 patients of which 700 patients (55.8%) were positive for psychiatric complications based on the general health (GHQ-28) questionnaire and 554 patients (44.1%) were negative, aged above 18 years old who had been infected with COVID19 (PCR swab confirmed) and recovered since less than 6 months without previous history of any psychiatric disease.

Results
Smoking, medical comorbidities, hospitalization, and cortisone in treatment were significantly higher in GHQ-28 positive than GHQ-28 negative (p < 0.05). Psychiatric disorders and Beck’s Depression Inventory (BDI) grades showed a significant association between smoking and hospitalization and Taylor Manifest Anxiety scales and smoking, hospitalization, and treatment with cortisone). Smoking, medical comorbidities, hospitalization, and cortisone in treatment were the most significant predictors of positive GHQ-28. However, multivariate analysis demonstrated that medical comorbidities, hospitalization, and cortisone in treatment were the best independent predictors of GHQ-28 positive (p = 7.055, p = 0.007, p = 0.043, p = 0.047, respectively).

Conclusions
COVID-19 cases without pre-existing psychological disorders exhibited a significant increase in psychiatric disorders occurrence 6 months following recovery. Anxiety disorders represented the predominant mental diagnoses documented.
A rare case of congenital right lobar segmental hepatic hypoplasia complicated by portal hypertension: a radiologic perspective
Authors: Bandyopadhyay Akash , Bansal Neha 
Published: May 2024

Abstract
Background
Segmental hypoplasia of liver is an infrequently encountered congenital anomaly which is clinically indolent and detected incidentally on cross sectional imaging or abdominal surgery which can have a myriad of surgical and medical implications. The unique radiological manifestations and associated complications makes it a diagnostically challenging entity.

Case presentation
We report a case of a middle-aged female presenting with complaints of non-specific abdominal pain for two years in which we reported the presence of segmental hypoplasia of right lobe complicated by development of portal hypertension incidentally detected on ultrasound examination which was followed up and confirmed on cross sectional imaging.

Conclusions
In this case report, we present a unique instance of congenital segmental hypoplasia of the liver, highlighting the intricacies of its radiological presentation, potential clinical implications, and the challenges associated with its diagnosis. By examining this rare anomaly, we aim to contribute to the growing body of knowledge surrounding hepatic developmental disorders, fostering a deeper understanding of the clinical spectrum, and facilitating improved patient care through enhanced diagnostic awareness.
Correlation between quantitative HBsAg and quantitative HBV DNA in chronic hepatitis B patients: a systematic review and meta-analysis
Authors: Maimunah Ummi , Wardhani Puspa , Wungu Citrawati Dyah Kencono , Rahmanda Anisa Firdausi , Kurniawan Andreas Agung , Palayukan Andrio 
Published: May 2024

Abstract
Background
HBV DNA assays have several limitations including being expensive and not widely available. Detection of HBsAg in serum has been the hallmark of HBV infection. However, previous studies regarding the association between HBsAg and HBV DNA revealed contradictory results. This study aims to reassess the correlation between HBsAg and HBV DNA in chronic hepatitis B patients.

Methods
Observational studies with näive chronic hepatitis B patients were included, while studies with other coinfections were excluded. The studies were identified by searching through Google Scholar, PubMed, ScienceDirect, and Springer Link for English and Bahasa articles from 2011 to 2021. The Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) was followed. Study quality was assessed using the Joanna Briggs Institute (JBI) critical appraisal.

Results
A total of 17 studies with 4134 participants met the criteria. The overall analysis revealed a moderate correlation between quantitative HBsAg and quantitative HBV DNA in the total sample of chronic hepatitis B patients (r = 0.57, 95% CI 0.40–0.75, P < 0.00001). In HBeAg + group, a moderate correlation was indicated while in HBeAg − revealed a weak association (r = 0.55, 95% CI 0.39–0.70, P < 0.00001 vs r = 0.29, 95% CI 0.20–0.38, P < 0.00001). The strongest correlation was discovered in HBeAg + chronic HBV infection phase (r = 0.59, 95% CI 0.35–0.82, P < 0.00001).

Conclusion
Serum HBsAg titer supports as a predictor of serum HBV DNA levels in clinical practice with moderate strength of correlation.

Trial registration
This review had been registered in PROSPERO (ID: CRD42023421246).
Multiple anaplastic lymphoma kinase-positive primary inflammatory myofibroblastic tumors with spontaneously expanding and shrinking nodules in both lungs: a case report
Authors: Nomura Shunsuke , Kaji Mitsuhito , Shiina Nobuyuki , Chiba Ryohei , Cho Yasushi , Shiiya Haruhiko , Kato Tatsuya 
Published: May 2024

Abstract
Background
Inflammatory myofibroblastic tumors (IMTs) are uncommon neoplasms most prevalent in individuals under 40 years old and predominantly in the lungs. Despite their rarity, multiple anaplastic lymphoma kinase (ALK)-positive IMTs, especially those of various sizes, have not been widely reported. This report describes a case of multiple ALK-positive IMTs in the lungs, aiming to further our understanding of their behavior and management.

Case presentation
Herein, we present the case of a 64-year-old woman who presented with an abnormal shadow on chest examination. Chest computed tomography revealed a main tumor in the right middle lobe and multiple irregularly shaped small nodules in both lungs. Thus, thoracoscopic wedge resection of the left lower lobe was performed for diagnosis. Pathological findings indicated smooth muscle proliferation without malignancy. IMT was diagnosed following thoracoscopic right middle lobectomy. Twenty months postoperatively, one residual nodule shrank, but another grew.

Conclusions
This is the first report of multiple ALK-positive IMTs in both lungs, highlighting the need for definitive diagnosis and treatment of IMTs based on surgical resection. Although caution is required in patients with lymph node metastases or distant metastases, careful follow-up is acceptable unless there is a tendency for nodules to increase in size on imaging.
Gut metagenomic analysis of gastric cancer patients reveals Akkermansia, Gammaproteobacteria, and Veillonella microbiota as potential non-invasive biomarkers
Authors: Nath Anju R. , Natarajan Jeyakumar 
Published: May 2024

AbstractThe goal of the study was to investigate the changes in the gut microbiota during the advancement of gastric cancer (GC) and identify pertinent taxa associated with the disease. We used a public fecal amplicon gastric cancer dataset from the Sequence Retrieval Archive (SRA), of patients with GC, gastritis, and healthy individuals. We did sequence pre-processing, including quality filtering of the sequences. Then, we performed a diversity analysis, evaluating α- and β-diversity. Next, taxonomic composition analysis was performed and the relative abundances of different taxa at the phylum and genus levels were compared between GC, gastritis, and healthy controls. The obtained results were subsequently subjected to statistical validation. To conclude, metagenomic function prediction was carried out, followed by correlation analysis between the microbiota and KEGG pathways. α analysis revealed a significant difference between male and female categories, while β analysis demonstrated significant distinctions between GC, gastritis, and healthy controls, as well as between sexes within the GC and gastritis groups. The statistically confirmed taxonomic composition analysis highlighted the presence of the microbes Bacteroides and Veillonella. Furthermore, through metagenomic prediction analysis and correlation analysis with pathways, three taxa, namely Akkermansia, Gammaproteobacteria, and Veillonella, were identified as potential biomarkers for GC. Additionally, this study reports, for the first time, the presence of two bacteria, Desulfobacteriota and Synergistota, in GC, necessitating further investigation. Overall, this research sheds light on the potential involvement of gut microbiota in GC pathophysiology; however, additional studies are warranted to explore its functional significance.
Pilot Validation of a 3-Dimensional Printed Pituitary Adenoma, Vascular Injury, and Cerebrospinal Fluid Leak Surgical Simulator
Authors: Candy Nicholas G. , Zhang Alexander S. , Bouras George , Jukes Alistair K. , Santoreneos Stephen , Vrodos Nick , Wormald Peter-John , Psaltis Alkis J. 
Published: May 2024

BACKGROUND AND OBJECTIVES:
Endoscopic skull base surgery is a subspecialty field which would benefit significantly from high-fidelity surgical simulators. Giving trainees the opportunity to flatten their learning curve by practicing a variety of procedures on surgical simulators will inevitably improve patient outcomes.

METHODS:
Four neurosurgeons, 8 otolarynologists, and 6 expert course faculty agreed to participate. All participants were asked to perform a transsphenoidal exposure and resection of a pituitary adenoma, repair a cerebrospinal fluid (CSF) leak, control a carotid injury, and repair a skull base defect. The content, face, and construct validity of the 3-dimensional printed model was examined.

RESULTS:
The heart rate of the participants significantly increased from baseline when starting the carotid injury simulation (mean 90 vs 121, P = .029) and significantly decreased once the injury was controlled (mean 121 vs 110, P = .033, respectively). The participants reported a significant improvement in anxiety in facing a major vascular injury, as well as an increase in their confidence in management of major vascular injury, resecting a pituitary adenoma and repair of a CSF leak using a 5-point Likert scale (mean 4.42 vs 3.58 P = .05, 2 vs 3.25 P < .001, 2.36 vs 4.27 P < .001 and 2.45 vs 4.0 P = .001, respectively). The mean Objective Structured Assessment of Technical Skills score for experienced stations was 4.4, significantly higher than the Objective Structured Assessment of Technical Skills score for inexperienced stations (mean 3.65, P = .016).

CONCLUSION:
We have demonstrated for the first time a validated 3-dimensional printed surgical simulator for endoscopic pituitary surgery that allows surgeons to practice a transsphenoidal approach, surgical resection of a pituitary adenoma, repair of a CSF leak in the diaphragma sellae, control of a carotid injury, and repair of skull base defect.
The glucocorticoid receptor acts locally to protect dystrophic muscle and heart during disease
Authors: Oliver Trinitee , Nguyen Nhu Y. , Tully Christopher B. , McCormack Nikki M. , Sun Christina M. , Fiorillo Alyson A. , Heier Christopher R. 
Published: May 2024

ABSTRACT
Absence of dystrophin results in muscular weakness, chronic inflammation and cardiomyopathy in Duchenne muscular dystrophy (DMD). Pharmacological corticosteroids are the DMD standard of care; however, they have harsh side effects and unclear molecular benefits. It is uncertain whether signaling by physiological corticosteroids and their receptors plays a modifying role in the natural etiology of DMD. Here, we knocked out the glucocorticoid receptor (GR, encoded by Nr3c1) specifically in myofibers and cardiomyocytes within wild-type and mdx52 mice to dissect its role in muscular dystrophy. Double-knockout mice showed significantly worse phenotypes than mdx52 littermate controls in measures of grip strength, hang time, inflammatory pathology and gene expression. In the heart, GR deletion acted additively with dystrophin loss to exacerbate cardiomyopathy, resulting in enlarged hearts, pathological gene expression and systolic dysfunction, consistent with imbalanced mineralocorticoid signaling. The results show that physiological GR functions provide a protective role during muscular dystrophy, directly contrasting its degenerative role in other disease states. These data provide new insights into corticosteroids in disease pathophysiology and establish a new model to investigate cell-autonomous roles of nuclear receptors and mechanisms of pharmacological corticosteroids.
STUDENTS' READINESS TO MAKE STRATEGIC DECISIONS: DEVELOPMENT OF PSYCHOLOGICAL AND PEDAGOGICAL DIAGNOSTIC METHODS
Authors: Moskaleva Lyudmila Y. , Shevchenko Yuri V. 
Published: May 2024

The purpose of the study is to theoretically substantiate the structure of students' readiness to make strategic decisions. It is also in formulating a list of statements to assess the level of students' readiness to make strategic decisions based on ideas about this construct.
Research objectives:
− to actualize the problem of youth strategic orientation in the value-semantic modernization of modern higher education;
– to form a cognitive image of assessing the level of students’ readiness to make strategic decisions;
– to generalize the idea of the importance of personality-oriented, individual factors in designing and diagnosing of students’ readiness to make strategic decisions.
Methodology. Systematic, professionographic, personality-oriented and value-based approaches are used in the article to build psychological and pedagogical methodology; the main research methods are analysis, synthesis, induction and deduction.
Results. The authors propose the basis for building a psychological and pedagogical diagnosis of students' readiness to make strategic decisions as a result of the conducted research.
The readiness to make strategic decisions gives opportunities for improving educational work with students, which enables to prioritize students' own future activities. It also helps to elaborate the ability to reflect and determine directions for personal and professional development , the skills to rationally allocate resources to achieve significant results. The positions substantiated in the study (the choice of priority life strategies, the ability to reflect on the difficulties arising in life, focus on sociability, on rationally determined individual intentions, values and results, etc.) are advisable to use in educational work with subjects of the cultural and educational space.
Information about sponsorship. The research was carried out within the framework of the scientific theme "Research of students' readiness to make strategic decisions in the changing cultural and educational space" (registration number:123112100032-8).
THE RELATIONSHIP BETWEEN PERCEIVED SOCIAL SUPPORT AND SYMPTOMS OF CPTSD IN VICTIMS OF DOMESTIC VIOLENCE
Authors: Redyuk Anna N. 
Published: May 2024

Objective. The article is devoted to the peculiarities of traumatization of persons affected by domestic violence. The subject is the nature of the relationship between perceived social support (PSS) and symptoms of complex post-traumatic stress disorder (CPTSD) for the development of methods of helping victims of domestic violence. Long-term traumatic impact on the injured person from a significant loved one, in the absence of adequate and sufficient social support, can manifest itself in re-experiencing, hypervigilance, emotional dysregulation, the formation of a negative self-image, and disturbances in close relationships.
Methodology. The study was carried out using the International Trauma Questionnaire (ITQ) and the Multidimensional Scale of Perceived Social Support (MSPSS). 99 people aged 18 to 61 years old with experience of domestic violence were interviewed. The methods used were descriptive analysis, checking the normality of variables using the Kolmagorov-Smirnov test, and C. Spearman’s correlation analysis.
Results. Individuals with more severe CPTSD symptoms were found to demonstrate lower levels of PSS. Therefore, to minimize the symptoms of CPTSD, it is advisable to develop skills related to social interaction and building close relationships.
Practical implications. The results are applicable in the process of providing crisis and rehabilitation psychological assistance to victims of domestic violence.
Models for Test Cost Minimization in Database Migration
Authors: Caskurlu Bugra , Subramani K. , Acikalin Utku Umur , Velasquez Alvaro , Wojciechowski Piotr 
Published: May 2024

Database migration is a ubiquitous need faced by enterprises that generate and use vast amounts of data. This is because of database software updates, or it is from changes to hardware, project standards, and other business factors. Migrating a large collection of databases is a way more challenging task than migrating a single database because of the presence of additional constraints. These constraints include capacities of shifts and sizes of databases. In this paper, we present a comprehensive framework that can be used to model database migration problems of different enterprises with customized constraints by appropriately instantiating the parameters of the framework. These parameters are the size of each database, the size of each shift, and the cost of testing each application. Each of these parameters can be either constant or arbitrary. Additionally, the cost of testing an application can be proportional to the number of databases that the application uses. We establish the computational complexities of a number of instantiations of this framework. We present fixed-parameter intractability results for various relevant parameters of the database migration problem. We also provide approximability and inapproximability results as well as lower bounds for the running time of any exact algorithm for the database migration problem. We show that the database migration problem is equivalent to a variation of the classical hypergraph partitioning problem. Our theoretical results also imply new theoretical results for the hypergraph partitioning problem that are interesting in their own right. Finally, we adapt heuristic algorithms devised for the hypergraph partitioning problem to the database migration problem, and we also give experimental results for the adapted heuristics. History: Accepted by Pascal Van Hentenryck, Area Editor for Computational Modeling: Methods & Analysis. Funding: B. Caskurlu and U. U. Acikalin are supported by The Scientific and Technological Research Council of Türkiye [Grant 122E599]. Supplemental Material: The software that supports the findings of this study is available within the paper and its Supplemental Information ( https://pubsonline.informs.org/doi/suppl/10.1287/ijoc.2023.0021 ) as well as from the IJOC GitHub software repository ( https://github.com/INFORMSJoC/2023.0021 ). The complete IJOC Software and Data Repository is available at https://informsjoc.github.io/ .
Predictive Three-Dimensional Printing of Spare Parts with Internet of Things
Authors: Song Jing-Sheng , Zhang Yue 
Published: May 2024

Industry 4.0 integrates digital and physical technologies to transform work management, where two core enablers are the internet of things (IoT) and three-dimensional printing (3DP). IoT monitors complex systems in real time, whereas 3DP enables agile manufacturing that can respond to real-time information. However, the details of how these two can be integrated are not yet clear. To gain insights, we consider a scenario where a three-dimensional (3D) printer supplies a critical part to multiple machines that are embedded with sensors and connected through IoT. Although the public perception indicates that this integration would enable on-demand printing, our research suggests that this is not necessarily the case. Instead, the true benefit is the ability to print predictively. In particular, it is typically more effective for the 3D printer to predictively print to stock based on a threshold that depends on the system’s status. We also identify a printing mode called predictive print on demand that allows for minimal inventory, and we find the speed of 3DP to be the primary factor that influences its optimality. Furthermore, we assess the value of IoT in cost reductions by separately analyzing the impact of advance information from embedded sensors and the real-time information fusion through IoT. We find that IoT provides significant value in general. However, the conventional wisdom that IoT’s value scales up for larger systems is suitable only when the expansion is paired with appropriate 3DP capacity. Our framework can help inform investment decisions regarding IoT/embedded sensors and support the development of scheduling tools for predictive 3DP. This paper was accepted by David Simchi-Levi, operations management. Supplemental Material: The online appendix and data files are available at https://doi.org/10.1287/mnsc.2023.00978 .