bluuebunny/crossref_metadata_2025_split huggingface dataset:
ChemInform Abstract: Identification of Dihydropyridines that Reduce Cellular Tau Levels.
Authors: Evans Christopher G. , Jinwal Umesh K. , Makley Leah N. , Dickey Chad A. , Gestwicki Jason E. 
Published: April 2011

AbstractHantzsch synthesis and SAR of a series of dihydropyridines (39 examples) with an effect on the accumulation of tau are presented.
ChemInform Abstract: Regiocontrolled Gold(I)‐Catalyzed Cyclization Reactions of N‐(3‐Iodoprop‐2‐ynyl)‐N‐tosylanilines.
Authors: Moran‐Poladura Pablo , Suarez‐Pantiga Samuel , Piedrafita Maria , Rubio Eduardo , Gonzalez Jose M. 
Published: April 2011

AbstractDepending on the gold catalyst and the nature of the aryl substituents, selective formation of 3‐ or 4‐iodinated 1,2‐dihydroquinolines takes place.
ChemInform Abstract: Efficient One‐Pot Synthesis of Substituted 4,7‐Phenanthroline, Pyrano[3,2‐f]quinoline and Pyrano[3,2‐g]quinoline Derivatives by Aza‐Diels—Alder Reaction.
Authors: Majumdar K. C. , Ponra Sudipta , Ghosh Debankan , Taher Abu 
Published: April 2011

AbstractA novel and mild procedure allows the synthesis of title compounds via in situ formation of an imine intermediate which undergoes aza‐Diels—Alder reaction with phenylacetylene.
ChemInform Abstract: Cu(II) Catalyzed Oxidation‐[3 + 2] Cycloaddition‐Aromatization Cascade: Efficient Synthesis of Pyrrolo[2,1‐a]isoquinolines.
Authors: Yu Chenguang , Zhang Yianan , Zhang Shilei , Li Hao , Wang Wei 
Published: April 2011

AbstractAn efficient methodology for the one‐pot synthesis of biologically important pyrrolo[2.1‐a]isoquinolines, relying on a novel oxidation‐dipolar cycloaddition—aromatization cascade, is developed.
ChemInform Abstract: Spirocyclization of an N‐Acyliminium Ion with Substituted Pyridine: Stereoselective Synthesis of Tetracyclic Spirolactams Possessing the Pyridone Nucleus.
Authors: Abe Hideki , Takaya Kei‐ichi , Watanabe Kazuhiro , Aoyagi Sakae , Kibayashi Chihiro , Katoh Tadashi 
Published: April 2011

AbstractAn efficient method for the stereoselective synthesis of tetracyclic spirolactams is presented.
ChemInform Abstract: Simple and Efficient One Pot Synthetic Protocol to Construct Morpholin‐2‐ones.
Authors: Yellol Gorakh S. , Mohapatra Debendra K. , Gurjar Mukund K. , Sun Chung‐Ming 
Published: April 2011

AbstractA wide range of 3‐substituted N‐benzyl‐morpholine‐2‐ones are synthesized based on the condensation of amino acids with 1,2‐Dibromoethane.
ChemInform Abstract: Synthesis and Anticancer Evaluation of New Derivatives of 3‐Phenyl‐1,5‐dimethyl‐1H‐[1,2,4]triazolo[4′,3′:1,2′]pyrimido[4,5‐e] [1,3,4]oxadiazine.
Authors: Bakavoli Mehdi , Rahimizadeh Mohammad , Shiri Ali , Akbarzadeh Marzieh , Mousavi Seyed‐Hadi , Atapour‐Mashhad Hoda , Tayarani‐Najaran Zahra 
Published: April 2011

AbstractThe compound (IXd) is tested on the cancer cell lines MCF‐7 and HepG2 and decreases viability of the cells in a concentration‐dependent manner.
ChemInform Abstract: New Sulfur Bridged Neutral Annulenes. Structure, Physical Properties and Applications in Organic Field‐Effect Transistors.
Authors: Singh Kamaljit , Sharma Amit , Zhang Jing , Xu Wei , Zhu Daoben 
Published: April 2011

AbstractTitle compounds (V), synthesized starting from bis(thienyl)methanes (I) are found to display p‐type semiconductor behavior.
ChemInform Abstract: An Unusual Reaction of 2‐Ethoxyethenylphosphonic Dichloride with Resorcinol and Its Derivatives: Synthesis of Bicyclic Phosphonates with Endocyclic P—C Bond.
Authors: Sadykova Yulia M. , Knyazeva Irina R. , Burilov Alexander R. , Pudovik Michael A. , Dobrynin Alexey B. , Litvinov Igor A. , Sinyashin Oleg G. 
Published: April 2011

AbstractProduct structures are proved by X‐ray analysis.
ChemInform Abstract: Solid—Liquid Two‐Phase Alkylation of Tetraethyl Methylenebisphosphonate Under Microwave Irradiation.
Authors: Greiner Istvan , Gruen Alajos , Ludanyi Krisztina , Keglevich Gyoergy 
Published: April 2011

AbstractOptimum conditions for the two‐phase alkylation of tetraethyl methylenebisphosphonate (I) depend on the nature of the alkyl halide.
ChemInform Abstract: Isomerization of Diethyl 1‐Alkynylphosphonates to 1,3‐Dienylphosphonates Followed by Diels—Alder Reaction with Dead, Maleic Anhydride and Maleimide.
Authors: Azab Abdullatif , Quntar Abed Al Aziz , Antebi Tamar , Srebnik Morris 
Published: April 2011

AbstractThe two‐step synthesis starting from the compounds (I) to the compounds (IV), (VI), or (VII) can also be accomplished in an one‐pot reaction with comparable yields.
ChemInform Abstract: Efficient Ring Opening of Protected and Unprotected Aziridines Promoted by Stable Zinc Selenolate in Ionic Liquid.
Authors: Salman Syed M. , Schwab Ricardo S. , Alberto Eduardo E. , Vargas Josimar , Dornelles Luciano , Rodrigues Oscar E. D. , Braga Antonio L. 
Published: April 2011

AbstractAn efficient method is presented for the synthesis of chiral β‐seleno amines via ring‐opening reaction of aziridines (I) using zinc selenoate (II) as nucleophile.
ChemInform Abstract: Antiproliferative and Apoptotic Sesquiterpene Lactones from Carpesium faberi.
Authors: Li Xu‐Wen , Weng Liang , Gao Xue , Zhao Yun , Pang Fei , Liu Jian‐Hui , Zhang Hong‐Feng , Hu Jin‐Feng 
Published: April 2011

AbstractFour new (I)—(IV) and 13 known sesquiterpene lactones along with two known diterpenes are isolated from the whole plant mentioned in title.
ChemInform Abstract: A Synthetic Approach to Anhydroketopyranoses Having a 6,8‐Dioxabicyclo[3.2.1]octane Structure from Ketopyranoses.
Authors: Yamanoi Takashi , Matsumura Kazuhide , Matsuda Sho , Oda Yoshiki 
Published: April 2011

AbstractThe compounds (III) and (VIII) are quantitatively converted to the corresponding compounds (IV) and (IX) by using NaOMe in MeOH.
ChemInform Abstract: Total Synthesis of Rutaecarpine and Analogues by Tandem Azido Reductive Cyclization Assisted by Microwave Irradiation.
Authors: Kamal Ahmed , Reddy M. Kashi , Reddy T. Srinivasa , Santos Leonardo Silva , Shankaraiah Nagula 
Published: April 2011

AbstractA convenient three‐step synthesis is presented for rutaecarpine (Va) and analogues such as euxylophoricine A (Vb) and C (Vc) involving a microwave‐assisted nickel boride reduction in the final cyclization step.
ChemInform Abstract: Studies on the Biosynthesis of the Stephacidins and Notoamides. Total Synthesis of Notoamide S.
Authors: McAfoos Timothy J. , Li Shengying , Tsukamoto Sachiko , Sherman David H. , Williams Robert M. 
Published: April 2011

AbstractThe synthesis of notoamide S (V) is accomplished in seven steps from indole (I) in 19% overall yield.
ChemInform Abstract: Enantioselective Total Synthesis and Confirmation of the Absolute and Relative Stereochemistry of Streptorubin B.
Authors: Hu Dennis X. , Clift Michael D. , Lazarski Kiel E. , Thomson Regan J. 
Published: April 2011

AbstractThe synthetic studies confirm the (7′S) stereochemistry of the anti atropdiastereomer as the absotute configuration of the natural product.
ChemInform Abstract: Synthesis of 8,1′‐etheno and 8,2′‐ethano Bridged Guanosine Derivatives Using Radical Cyclization.
Authors: Strohmeier Julian , Nadler Andre , Heinrich Daniel , Fitzner Ansgar , Diederichsen Ulf 
Published: April 2011

AbstractConformationally constrained nucleosides are generated by radical cyclization reactions.
ChemInform Abstract: Stereoselective Synthesis of Caribbean Ciguatoxin M‐Ring Using [2 + 2] Photocyclization.
Authors: Yamashita Shuji , Iijima Naoya , Shida Takahiro , Hirama Masahiro 
Published: April 2011

AbstractA secure and stereocontrolled route to the seven‐membered M‐ring moiety of Caribbean ciguatoxin C‐CTX‐1 is developed featuring i) the photoinduced [2 + 2]cyclization to construct the cyclobutene structure (III), ii) the enzymatic desymmetrization of bis‐acetate (III), and iii) the stereoselective reduction of diketone (VII).
ChemInform Abstract: Highly Selective c‐Jun N‐Terminal Kinase (JNK) 2 and 3 Inhibitors with in vitro CNS‐Like Pharmacokinetic Properties Prevent Neurodegeneration.
Authors: Probst Gary D. , et al. et al. 
Published: April 2011

AbstractThe discovery of selective JNK2 and JNK3 inhibitors, such as (Ia), that routinely exhibit <10‐fold selectivity over JNK1 and <1000‐fold selectivity over related MAPKs, p38α and ERK2 is reported.
Antioxidant Enzymes Response in Vetiver Grass: A Greenhouse Study for Chelant‐Assisted Phytoremediation of Lead‐Contaminated Residential Soils
Authors: Andra Syam S. , Datta Rupali , Reddy Ramana , Saminathan Sumathi K. M. , Sarkar Dibyendu 
Published: April 2011

AbstractIn a previous study we have demonstrated the suitability of using vetiver grass (Vetiveria zizanioides L.) for the phytostabilization of lead‐based paint contaminated residential soils. Vetiver did not show any growth retardation or toxicity symptoms despite high soil Pb levels. Antioxidant enzymes like superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx) reportedly allow plants to combat metal stress. Thus, we hypothesized that in vetiver, these antioxidant enzymes can play an important role in combating Pb induced stress, and that chelant‐bound Pb is less toxic to vetiver compared to free Pb in soil. The response of antioxidant enzymes was studied in vetiver grass grown in Pb paint‐contaminated residential soils collected from San Antonio, Texas and Baltimore, Maryland. Chelating agents such as ethylenediaminetetraacetic acid (EDTA) and ethylenediaminedisuccinic acid (EDDS) were used to mobilize Pb from bound fractions to the labile pool, facilitating Pb uptake by vetiver. Although the Pb concentration in vetiver from these treatments was significantly higher than those grown in the absence of a chelant, the antioxidant enzymes activities were lower compared to the latter. Antioxidant enzymes activity of vetiver plants grown in the presence of chelants is lower compared to those in without chelant treatment, while they tended to increase with dose in treatments with varying chelant concentrations. Data obtained support the proposed hypothesis.
Response Surface Analysis and Statistical Modeling of Sulfide Generation from Municipal Wastewater
Authors: Zinatizadeh Ali Akbar , Bonakdari H. , Pirsaheb M. , Gharacheh E. 
Published: April 2011

AbstractIn this study, the interactive effects of four independent variables (initial chemical oxygen demand (COD) concentration, rotational velocity, temperature, and retention time) on the sulfide generation process in municipal wastewater were investigated. The process was modeled and analyzed with the variables in a series batch experiments. Experiments were conducted based on a central composite face‐centered design and analyzed using response surface methodology. The region of exploration for the process was taken as the area enclosed by COD (250 and 650 mg/L), rotational velocity (40 and 200 rpm), temperature (16 and 28°C), and retention time (2 and 40 h) boundaries. Eleven dependent parameters were either directly measured or calculated as response. The most influential variable on H2S (g) production was found to be retention time. The results showed that simultaneous increase in temperature and rotational velocity caused an increasing trend in the amount of H2S (g) emitted. Total sulfide was decreased by increasing rotational velocity due to more H2S (g) secretion resulting from increased mixing rate. The present study provides valuable information about interrelations of quality and process parameters at different values of the studied variables.
Prediagnostic smoking history, alcohol consumption, and colorectal cancer survival
Authors: Phipps Amanda I. , Baron John , Newcomb Polly A. 
Published: April 2011

AbstractBACKGROUND:Smoking and alcohol consumption are associated with an increased risk of developing colorectal cancer. However, it is unclear whether these exposures are associated with survival after colorectal cancer diagnosis.METHODS:Men and women diagnosed with incident colorectal cancer between 1998 and 2007 in 13 counties in western Washington State were identified by using the Surveillance, Epidemiology, and End Results cancer registry. Information on smoking history and alcohol consumption was collected by telephone interview. Follow‐up for mortality was completed through linkage to the National Death Index. Cox proportional hazards regression was used to estimate hazard ratios (HR) and 95% confidence intervals (CI) for associations among smoking, alcohol consumption, and mortality after colorectal cancer diagnosis. Stratified analyses were conducted by sex, age at diagnosis (<50 years, ≥50 years), tumor site (proximal, distal, rectal), stage (I‐II, III‐IV), and microsatellite instability status (stable/low, high).RESULTS:Disease‐specific and all‐cause mortality were significantly higher for smokers (HR, 1.30; 95% CI, 1.09‐1.74) compared with never‐smokers (HR, 1.51; 95% CI, 1.24‐1.83). However, this association was most prominent in those with tumors exhibiting high microsatellite instability (HR, 3.83; 95% CI, 1.32‐11.11) and did not extend to those with rectal cancer (HR, 1.08; 95% CI, 0.72‐1.61) or those diagnosed before age 50 years (HR, 0.99; 95% CI, 0.67‐1.48). Alcohol consumption was not associated with disease‐specific or all‐cause mortality, regardless of patient or tumor characteristics.CONCLUSIONS:In addition to an association with disease risk, smoking is associated with increased mortality after colorectal cancer diagnosis. This association is especially pronounced for colorectal cancer with high microsatellite instability. Cancer 2011;. © 2011 American Cancer Society.
Genetic amplification of the vascular endothelial growth factor (VEGF) pathway genes, including VEGFA, in human osteosarcoma
Authors: Yang Jilong , Yang Da , Sun Yan , Sun Baocun , Wang Guowen , Trent Jonathan C. , Araujo Dejka M. , Chen Kexin , Zhang Wei 
Published: April 2011

AbstractBACKGROUND:Osteosarcoma is the most common primary tumor of bone. It is a highly vascular and extremely destructive malignancy that mainly affects children and young adults. The authors conducted microarray‐based comparative genomic hybridization (aCGH) and pathway analyses to gain a systemic view of pathway alterations in the genetically altered genes.METHODS:Recurrent amplified and deleted genes that were detected by aCGH were subjected to an analysis based on the Kyoto Encyclopedia of Genes and Genomes to identify the altered pathways. Among the enriched pathways, vascular endothelial growth factor (VEGF) pathway genes collectively were amplified, and alterations of this pathway were validated by fluorescence in situ hybridization (FISH) and immunohistochemistry analyses in 58 formalin‐fixed, paraffin‐embedded osteosarcoma archival tissues that had clinical follow‐up information.RESULTS:The pathway enrichment analyses of the aCGH data revealed that VEGF pathway genes, including the VEGFA gene itself, were amplified significantly in osteosarcoma. Genetic amplification of the VEGFA gene, both focally and in larger fragment, was validated by FISH analysis. It is noteworthy that amplification of the VEGFA gene and elevated expression of the VEGFA protein were associated significantly with microvascular density and adverse tumor‐free survival in patients with osteosarcoma.CONCLUSIONS:The authors report for the first time that VEGF pathway genes, including the VEGFA gene, are amplified in osteosarcoma. Amplification of the VEGFA gene is not only an important mechanism for elevated VEGFA protein expression but also is a poor prognostic factor for tumor‐free survival. Combined classification of VEGFA gene amplification and positive VEGFA protein expression may provide a more accurate stratification method of selecting anti‐VEGF therapy for patients with osteosarcoma. Cancer 2011;. © 2011 American Cancer Society.
Clinical results and risk factors of proton and carbon ion therapy for hepatocellular carcinoma
Authors: Komatsu Shohei , Fukumoto Takumi , Demizu Yusuke , Miyawaki Daisuke , Terashima Kazuki , Sasaki Ryohei , Hori Yuichi , Hishikawa Yoshio , Ku Yonson , Murakami Masao 
Published: April 2011

AbstractBACKGROUND:The objective of this study was to evaluate the clinical outcome of proton and carbon ion therapy for hepatocellular carcinoma (HCC).METHODS:In total, 343 consecutive patients with 386 tumors, including 242 patients (with 278 tumors) who received proton therapy and 101 patients (with 108 tumors) who received carbon ion therapy, were treated on 8 different protocols of proton therapy (52.8‐84.0 gray equivalents [GyE] in 4‐38 fractions) and on 4 different protocols of carbon ion therapy (52.8‐76.0 GyE in 4‐20 fractions).RESULTS:The 5‐year local control and overall survival rates for all patients were 90.8% and 38.2%, respectively. Regarding proton and carbon ion therapy, the 5‐year local control rates were 90.2% and 93%, respectively, and the 5‐year overall survival rates were 38% and 36.3%, respectively. These rates did not differ significantly between the 2 therapies. Univariate analysis identified tumor size as an independent risk factor for local recurrence in proton therapy, carbon ion therapy, and in all patients. Multivariate analysis identified tumor size as the only independent risk factor for local recurrence in proton therapy and in all patients. Child‐Pugh classification was the only independent risk factor for overall survival in proton therapy, in carbon ion therapy, and in all patients according to both univariate and multivariate analyses. No patients died of treatment‐related toxicities.CONCLUSIONS:Proton and carbon ion therapies for HCC were comparable in terms of local control and overall survival rates. These therapies may represent innovative alternatives to conventional local therapies for HCC. Cancer 2011;. © 2011 American Cancer Society.
Sisters Peer Counseling in Reproductive Issues After Treatment (SPIRIT)
Authors: Schover Leslie R. , Rhodes Michelle M. , Baum George , Adams Jennifer Harned , Jenkins Rosell , Lewis Pamela , Jackson Karen Eubanks 
Published: April 2011

AbstractBACKGROUND:African American breast cancer survivors may be at high risk for reproductive health problems, including menopause symptoms, sexual dysfunction, and distress about cancer‐related infertility. The authors partnered with Sisters Network Inc. to create the Sisters Peer Counseling in Reproductive Issues After Treatment (SPIRIT) program, a culturally sensitive intervention program that combined a written workbook and peer counseling.METHODS:Three hundred women were randomized to receive either the workbook plus 3 in‐person sessions with a trained peer counselor or the workbook plus ≤30 minutes of telephone counseling to be initiated by the participant. Questionnaires at baseline, post‐treatment, and at 6‐month and 12‐month follow‐up assessed emotional distress, sexual function, relationship satisfaction, spirituality, menopause symptoms, and knowledge. Satisfaction with the program and the use of medical care also were assessed.RESULTS:Both groups of women improved significantly in knowledge, decreased in distress, and had decreased hot flashes. Sexually active women had improved sexual function at 6‐month follow‐up but not at 1 year. However, peer counseling had little incremental benefit over the telephone counseling.CONCLUSIONS:The SPIRIT program was rated very useful by 66% of women. Outcomes justify continued use of the workbook and further research to optimize the impact of peer counseling. Cancer 2011;. © 2011 American Cancer Society.
Decentralization of CD4 testing in resource‐limited settings: 7 years of experience in six African countries
Authors: Marinucci F. , Medina‐Moreno S. , Paterniti A. D. , Wattleworth M. , Redfield R. R. 
Published: April 2011

AbstractImproving access to CD4 testing in resource‐limited settings can be achieved through both centralized and decentralized testing networks. Decentralized testing models are more suitable for countries where the HIV epidemic affects a large portion of rural populations. Timely access to accurate CD4 results is crucial at the primary level of the health system. For the past 7 years, the Institute of Human Virology of the University of Maryland School of Medicine has implemented a flexible and sustainable three‐phase model: (1) site assessment and improvement, (2) appropriate technology selection with capacity building through practical training and laboratory mentoring, and (3) quality management system strengthening and monitoring, to support accessibility to reliable CD4 counting at the point of service. CD4 testing capacity was established in 122 of 229 (53%) laboratories supported in Nigeria, Uganda, Kenya, Zambia, Tanzania, and Rwanda. Among those in rural settings, 46% (69/151) had CD4 testing available at site level, with a functioning flow cytometer installed at 28% (8/29) and 50% (61/122) of level 1 and level 2 sites, respectively. To strengthen local capacity, a total of 1,152 laboratory technicians were trained through 188 training sessions provided both on‐site and at central locations. The overall quality of CD4 total testing procedure was assessed at 76% (92/121) of the laboratories, with 25% (23/92), 34% (31/92), and 33% (30/92) of them reporting excellent, good, and satisfactory performance. Balancing country‐specific factors with the location of the clinic, number of patients, and the expected workload, was crucial in adapting this flexible model for decentralizing CD4 testing. The close collaboration with local governments and private vendors was key to successfully expanding access to CD4 testing within the framework of HIV care and treatment programs and for the sustainability of medical laboratories in resource‐limited settings. © 2011 International Society for Advancement of Cytometry
Design and synthesis of novel NO‐donor‐ferulic acid hybrids as potential antiatherosclerotic drug candidatesa
Authors: Li Nian‐Guang , Wang Rong , Shi Zhi‐Hao , Tang Yu‐Ping , Li Bao‐Quan , Wang Zhen‐Jiang , Song Shu‐Lin , Qian Li‐Hua , Wei Li , Yang Jian‐Ping , Yao Li‐Juan , Xi Jun‐Zuan , Xu Jia , Feng Feng , Qian Da‐Wei , Duan Jin‐Ao 
Published: April 2011

AbstractNovel NO‐donor‐ferulic acid hybrids were designed and synthesized through a symbiotic approach using ferulic acid and three different NO‐donating groups, such as nitric ester, 4‐hydroxyl‐3‐phenylfuroxan, and 4‐hydroxymethyl‐3‐phenylsulfonylfuroxan. Antioxidant, nitric oxide release, and vasodilator properties studies showed that the target phenylsulfonylfuroxan 14, especially 14c, while keeping the antioxidant activity, showed more NO release activity and vasodilating activity than isosorbide dinitrate (ISDN). Thus, 14c may be considered a novel potent anti‐atherosclerosis drug candidate. Drug Dev Res 72: 405–415, 2011. © 2011 Wiley‐Liss, Inc.
Tips for success: Getting more done in less time
Authors: Kiefer Julie C. 
Published: April 2011

AbstractWhether a student or full professor, it seems there is never enough time in the day to get everything done. Yet as a scientist rises through the ranks, somehow she is expected to do even more. Excellent time management skills enable one to work more effectively, and to accomplish more in less time. Therefore, the ability to manage time well is paramount to success. Here, three busy full professors, David Kimelman, Ph.D., Thomas Rando, Ph.D., and Monica Vetter, Ph.D. share tips on how they organize and prioritize their time, and cope with unexpected demands. Developmental Dynamics 240:1635–1637, 2011. © 2011 Wiley‐Liss, Inc.