bluuebunny/crossref_metadata_2025_split huggingface dataset:
Analysis of Prevalence, Socioeconomic and Disease Trends of Non-Melanoma Skin Cancer in New Zealand from 2008 to 2022
Authors: Paul Sharad , Chen Yipan , Mohaghegh Mahsa 
Published: June 2024

Abstract
Background
Skin cancer shows geographic and ethnic variation. New Zealand—with a predominantly fair-skinned populations, high UV indices and outdoor lifestyles—has high rates of skin cancer. However, population prevalence data is lacking. This study aimed to determine the demographics and socioeconomic disease trends of non-melanoma skin cancer prevalence in New Zealand from a large targeted-screening study.

Methods
A targeted screening programme was conducted among 32,839 individuals, Fitzpatrick Skin Types I to IV in Auckland, New Zealand during the 2008–2022 period. This data was analyzed retrospectively. Linear regression models were used to assess statistical trends of skin cancer prevalence over time, along with associated factors that included demographics, disease trends and overall prevalence.

Results
A total of 32,839 individuals were screened and 11,625 skin cancers were detected. 16,784 individuals were females who had 4,378 skin cancers. 16,055 individuals were males who had 5,777 skin cancers. 54 males and 65 females had multiple skin cancers. The article presents detailed descriptions of tumour types and subtypes detected, age groups, demographic and socioeconomic information. regarding the non-melanoma skin cancers detected.

Conclusion
Overall men have more non-melanoma skin cancer (NMSC) than females; however females develop more BCC on the lips. BCC is three times more common in the 31-50 age group, whereas SCC are significantly more prevalent after age 80. Prevalence of BCC has not changed over the 15-year timeframe of the study but SCC has increased. Older ages and higher incomes are associated with higher rates of NMSC in New Zealand.
Embolization of a splenic artery aneurysm: a case report
Authors: Verde Caterina , Tarotto Luca , Stilo Salvatore , D’Angelo Roberto , Fiore Francesco 
Published: June 2024

AbstractSplenic artery aneurysm (SAA) is the most common aneurysm of the visceral arteries. SAA can be silent and asymptomatic; rupture is a rare but serious complication that can manifest as acute diffuse abdominal pain and hypovolemic shock with a high risk of mortality. Surgery is the traditional treatment, but has the disadvantage of severe surgical injuries, a high risk of complications and a high mortality rate. We present the case of a 58-year-old woman with a saccular aneurysm of the middle segment of the splenic artery; she was treated by coiling embolization using the sandwich technique. Contrast-enhanced computed tomography (CECT) controls at one month, four months and one year showed progressive reduction and complete devascularization of the aneurysmal sac. Embolization of the splenic artery aneurysm is an effective and safe treatment.
Dissipation Rates of Mesospheric Stratified Turbulence From Multistatic Meteor‐Radar Observations
Authors: Vierinen J. , Poblet F. L. , Chau J. L. , Avsarkisov V. , Pécseli H. L. , Tsutsumi M. , Nozawa S. , Johnsen M. G. , Latteck R. , Gulbrandsen N. 
Published: June 2024

AbstractStratified turbulence (ST) has been proposed as a model for the dynamics of the mesosphere‐lower thermosphere (MLT) region. This theory postulates that for horizontal mesoscales (∼1–400 km), the kinetic energy of horizontal winds dissipates from large to small scales with an approximately mean constant rate. In this investigation, dissipation rates are quantified using meteor‐radar observations conducted in Northern Norway. The observed seasonal variability of dissipation rates exhibits maxima during the summer and winter, and minima near the equinoxes, between 80 and 95 km altitude. The results are compared with model predictions and earlier medium frequency radar, rocket, lidar, and satellite observations of MLT turbulence. The findings suggest that multi‐static meteor radar measurements of ST can provide a novel way to continuously monitor turbulent dissipation rates in the MLT region.
Dust Accumulation and Lifting at the Landing Site of the Mars 2020 Mission, Jezero Crater, as Observed From MEDA
Authors: Vicente‐Retortillo A. , Lemmon M. T. , Martinez G. M. , Toledo D. , Apéstigue V. , Arruego I. , Bertrand T. , Lorenz R. , Sebastián E. , Hueso R. , Newman C. , Smith M. D. , Rodriguez‐Manfredi J. A. 
Published: June 2024

AbstractWe quantify the effect of dust accumulation at Jezero crater by means of a Dust Correction Factor (DCF) for the solar radiation measured by the photodiodes of the Radiation and Dust Sensor of the Mars 2020 mission. After one Mars Year, dust on the photodiode surface attenuated 25%–30% of the incoming solar radiation. The DCF did not decrease monotonically; we use a model to reproduce its evolution and to derive dust deposition and lifting rates, showing that dust removal is 9 times larger at Jezero crater than at InSight's location in western Elysium Planitia. The model fit obtained using observed opacities is further improved when fed with dust sedimentation rates simulated by a GCM that considers a particle size distrtibution. Projections show seasonal net dust removal, being encouraging for the long‐term survival of solar‐powered missions to Jezero or similarly active dust lifting regions.
Simulation of Compound Flooding Using River‐Ocean Two‐Way Coupled E3SM Ensemble on Variable‐Resolution Meshes
Authors: Feng Dongyu , Tan Zeli , Engwirda Darren , Wolfe Jonathan D. , Xu Donghui , Liao Chang , Bisht Gautam , Benedict James J. , Zhou Tian , Li Hong‐Yi , Leung L. Ruby 
Published: June 2024

AbstractCoastal zone compound flooding (CF) can be caused by the interactive fluvial and oceanic processes, particularly when coastal backwater propagates upstream and interacts with high river discharge. The modeling of CF is limited in existing Earth System Models (ESMs) due to coarse mesh resolutions and one‐way coupled river‐ocean components. In this study, we present a novel multi‐scale coupling framework within the Energy Exascale Earth System Model (E3SM), integrating global atmosphere and land with interactively coupled river and ocean models using different meshes with refined resolutions near the coastline. To evaluate this framework, we conducted ensemble simulations of a CF event (Hurricane Irene in 2011) in a Mid‐Atlantic estuary. The results demonstrate that the novel E3SM configuration can reasonably reproduce river discharge and sea surface height variations. The two‐way river‐ocean coupling improves the representation of coastal backwater effects at the terrestrial‐aquatic interface that are caused by the combined actions of tide and storm surge during the CF event, thus providing a valuable modeling tool for better understanding the river‐estuary‐ocean dynamics in extreme events under climate change. Notably, our results show that the most significant CF impacts occur when the highest storm surge generated by a tropical cyclone meets with a moderate river discharge. This study highlights the state‐of‐the‐art advancements developed within E3SM for simulating multi‐scale coastal processes.
Observational Constraints and Attribution of Global Plant Transpiration Changes Over the Past Four Decades
Authors: Cui Jiangpeng , Ding Jinzhi , Lian Xu , Wei Zhongwang , Li Shijie , Peng Jian , Poyatos Rafael , Wang Tao , Piao Shilong 
Published: June 2024

AbstractAccurate estimation and attribution of large‐scale changes in plant transpiration are critical to understand the impacts of vegetation dynamics on the terrestrial hydrological cycle. However, these aspects remain poorly understood due to the limited reliability of global transpiration products. Here we compile data from 101 site‐based transpiration measurements across the globe and use them to constrain three biophysically based data‐driven transpiration products. The constrained transpiration reveals a prominent increasing trend of 0.61–0.79 mm yr−2 during 1980–2021, which is overestimated by 8%–32% in unconstrained transpiration. We further find that the global transpiration increase is mainly driven by leaf area index increase (40%), followed by climate change (19%), though offset partly by CO2‐induced stomatal closure (−38%) and land use and cover change (−3%). Our refined estimates indicate a less substantial increase of global transpiration than previously thought, improving the understanding of transpiration change impact on global hydrological cycle.
Timescales of Autogenic Noise in River Bedform Evolution and Stratigraphy
Authors: Ganti Vamsi , Kelley Madeline M. , Das Debsmita , Mahon Robert C. 
Published: June 2024

AbstractBedform evolution and preserved cross strata are known to respond to floods. However, it is unclear if autogenic dynamics mask the flood signal in bedform evolution and cross strata. To address this, we characterize the temporal structure of autogenic noise in steady‐state bedform evolution in a physical experiment. Results reveal the existence of bedform groups—quasi‐stable collections of bedforms—that migrate at a similar speed as bedforms. We find that bedform and bedform‐group turnover timescales are the key autogenic timescales of bed evolution that set the transition time‐periods between different noise regimes in bedform evolution. Results suggest that bedform‐group turnover timescale sets the lower limit for detecting flood signals in bedform evolution, and floods with duration shorter than bedform turnover timescale can be severely degraded in bedform evolution and cross strata. Our work provides a new framework for interrogating fluvial cross strata for reconstruction of past floods.
ETV6::RUNX1 Acute Lymphoblastic Leukemia: how much therapy is needed for cure?
Authors: Østergaard Anna , Fiocco Marta , de Groot-Kruseman Hester , Moorman Anthony V. , Vora Ajay , Zimmermann Martin , Schrappe Martin , Biondi Andrea , Escherich Gabriele , Stary Jan , Imai Chihaya , Imamura Toshihiko , Heyman Mats , Schmiegelow Kjeld , Pieters Rob 
Published: June 2024

AbstractRecent trials show 5-year survival rates >95% for ETV6::RUNX1 Acute Lymphoblastic Leukemia (ALL). Since treatment has many side effects, an overview of cumulative drug doses and intensities between eight international trials is presented to characterize therapy needed for cure. A meta-analysis was performed as a comprehensive summary of survival outcomes at 5 and 10 years. For drug dose comparison in non-high risk trial arms, risk group distribution was applied to split the trials into two groups: trial group A with ~70% (range: 63.5–75%) of patients in low risk (LR) (CCLSG ALL2004, CoALL 07-03, NOPHO ALL2008, UKALL2003) and trial group B with ~45% (range: 38.7–52.7%) in LR (AIEOP-BFM ALL 2000, ALL-IC BFM ALL 2002, DCOG ALL10, JACLS ALL-02). Meta-analysis did not show evidence of heterogeneity between studies in trial group A LR and medium risk (MR) despite differences in treatment intensity. Statistical heterogeneity was present in trial group B LR and MR. Trials using higher cumulative dose and intensity of asparaginase and pulses of glucocorticoids and vincristine showed better 5-year event-free survival but similar overall survival. Based on similar outcomes between trials despite differences in therapy intensity, future trials should investigate, to what extent de-escalation is feasible for ETV6::RUNX1 ALL.
Theta burst stimulation for depression: a systematic review and network and pairwise meta-analysis
Authors: Kishi Taro , Ikuta Toshikazu , Sakuma Kenji , Hatano Masakazu , Matsuda Yuki , Wilkening Jonas , Goya-Maldonado Roberto , Tik Martin , Williams Nolan R. , Kito Shinsuke , Iwata Nakao 
Published: June 2024

AbstractIn clinical practice, theta burst stimulation (TBS) presents as a more efficient and potentially more effective therapeutic modality than conventional repetitive transcranial magnetic stimulation (rTMS), as it allows for the delivery of more stimuli in less time and at similar intensities. To date, accelerated treatment plans according to various continuous (cTBS) and intermittent TBS (iTBS) protocols for depression have been proposed. To investigate which of the TBS protocols provided a favorable risk-benefit balance for individuals with depression, this systematic review and random-effects model network meta-analysis was conducted. The study outcomes included response rate (primary), depression symptom improvement, remission rate, all-cause discontinuation rate, incidence of switch to mania, and incidence of headache/discomfort at treatment site. In this meta-analysis, a total of 23 randomized controlled trials (n = 960, mean age = 41.88 years, with 60.78% females) were included. Approximately 69.57% of the trials included individuals with an exclusive diagnosis of major depressive disorder. The following six TBS protocols (target) were evaluated: cTBS (right-dorsolateral prefrontal cortex [R-DLPFC]), cTBS (R-DLPFC) + iTBS (left-DLPFC [L-DLPFC]), iTBS (L-DLPFC), iTBS (L-DLPFC) + iTBS (R-DLPFC), iTBS (left-dorsomedial prefrontal cortex) + iTBS (right-dorsomedial prefrontal cortex), and iTBS (occipital lobe). Compared to sham, cTBS (R-DLPFC) + iTBS (L-DLPFC), iTBS (L-DLPFC), and iTBS (occipital lobe) had a higher response rate (k = 23); cTBS (R-DLPFC) + iTBS (L-DLPFC) and iTBS (L-DLPFC) dominated in the depression symptom improvement (k = 23); and iTBS (L-DLPFC) had a higher remission rate (k = 15). No significant differences were found for all-cause discontinuation rate (k = 17), incidence of switch to mania (k = 7), and incidence of headache/discomfort at treatment site (k = 10) between any TBS protocols and sham. Thus, cTBS (R-DLPFC) + iTBS (L-DLPFC) and iTBS (L-DLPFC) demonstrate favorable risk-benefit balance for the treatment of depression.
From real world data to real world evidence to improve outcomes in neuro-ophthalmology
Authors: Colman Blake D. , Zhu Zhuoting , Qi Ziyi , van der Walt Anneke 
Published: June 2024

AbstractReal-world data (RWD) can be defined as all data generated during routine clinical care. This includes electronic health records, disease-specific registries, imaging databanks, and data linkage to administrative databases. In the field of neuro-ophthalmology, the intersection of RWD and clinical practice offers unprecedented opportunities to understand and treat rare diseases. However, translating RWD into real-world evidence (RWE) poses several challenges, including data quality, legal and ethical considerations, and sustainability of data sources. This review explores existing RWD sources in neuro-ophthalmology, such as patient registries and electronic health records, and discusses the challenges of data collection and standardisation. We focus on research questions that need to be answered in neuro-ophthalmology and provide an update on RWE generated from various RWD sources. We review and propose solutions to some of the key barriers that can limit translation of a collection of data into impactful clinical evidence. Careful data selection, management, analysis, and interpretation are critical to generate meaningful conclusions.
The hippocampus dissociates present from past and future goals
Authors: Montagrin Alison , Croote Denise E. , Preti Maria Giulia , Lerman Liron , Baxter Mark G. , Schiller Daniela 
Published: June 2024

AbstractOur brain adeptly navigates goals across time frames, distinguishing between urgent needs and those of the past or future. The hippocampus is a region known for supporting mental time travel and organizing information along its longitudinal axis, transitioning from detailed posterior representations to generalized anterior ones. This study investigates the role of the hippocampus in distinguishing goals over time: whether the hippocampus encodes time regardless of detail or abstraction, and whether the hippocampus preferentially activates its anterior region for temporally distant goals (past and future) and its posterior region for immediate goals. We use a space-themed experiment with 7T functional MRI on 31 participants to examine how the hippocampus encodes the temporal distance of goals. During a simulated Mars mission, we find that the hippocampus tracks goals solely by temporal proximity. We show that past and future goals activate the left anterior hippocampus, while current goals engage the left posterior hippocampus. This suggests that the hippocampus maps goals using timestamps, extending its long axis system to include temporal goal organization.
Calcite carbonate sinks low-density plastic debris in open oceans
Authors: Sun Xiang-Fei , Zhang Yanxu , Xie Meng-Yi , Mai Lei , Zeng Eddy Y. 
Published: June 2024

AbstractThe vertical settling of plastic debris in oceans is poorly understood. A large share of low-density microplastics (LDMPs) are largely absent from sea surfaces. The present study employs a model that considers the potential of an overlooked microbially induced calcium carbonate precipitation (MICP) process and new motion equations for irregular LDMPs. Here we show that the motion of LDMPs in the present model, exhibiting a damped oscillation pattern, is quite different from that in biofouling models. Furthermore, LDMPs in the size range of 10–200 µm are most likely to gain sufficient density at the biofouling/MICP stage to independently sink to the ocean floor with relatively small drag coefficients, potentially explaining the selective enrichment of LDMPs in the oceanic sediment. The size and shape exhibit strong non-linear effects on the settling patterns of LDMPs. Overall, the present study highlights the importance of calcite-mediated sinking of LDMPs in open oceans.
Central transcriptional regulator controls photosynthetic growth and carbon storage in response to high light
Authors: Steichen Seth , Deshpande Arnav , Mosey Megan , Loob Jessica , Douchi Damien , Knoshaug Eric P. , Brown Stuart , Nielsen Robert , Weissman Joseph , Carrillo L. Ruby , Laurens Lieve M. L. 
Published: June 2024

AbstractCarbon capture and biochemical storage are some of the primary drivers of photosynthetic yield and productivity. To elucidate the mechanisms governing carbon allocation, we designed a photosynthetic light response test system for genetic and metabolic carbon assimilation tracking, using microalgae as simplified plant models. The systems biology mapping of high light-responsive photophysiology and carbon utilization dynamics between two variants of the same Picochlorum celeri species, TG1 and TG2 elucidated metabolic bottlenecks and transport rates of intermediates using instationary 13C-fluxomics. Simultaneous global gene expression dynamics showed 73% of the annotated genes responding within one hour, elucidating a singular, diel-responsive transcription factor, closely related to the CCA1/LHY clock genes in plants, with significantly altered expression in TG2. Transgenic P. celeri TG1 cells expressing the TG2 CCA1/LHY gene, showed 15% increase in growth rates and 25% increase in storage carbohydrate content, supporting a coordinating regulatory function for a single transcription factor.
Development and organization of the retinal orientation selectivity map
Authors: Vita Dominic J. , Orsi Fernanda S. , Stanko Nathan G. , Clark Natalie A. , Tiriac Alexandre 
Published: June 2024

AbstractOrientation or axial selectivity, the property of neurons in the visual system to respond preferentially to certain angles of visual stimuli, plays a pivotal role in our understanding of visual perception and information processing. This computation is performed as early as the retina, and although much work has established the cellular mechanisms of retinal orientation selectivity, how this computation is organized across the retina is unknown. Using a large dataset collected across the mouse retina, we demonstrate functional organization rules of retinal orientation selectivity. First, we identify three major functional classes of retinal cells that are orientation selective and match previous descriptions. Second, we show that one orientation is predominantly represented in the retina and that this predominant orientation changes as a function of retinal location. Third, we demonstrate that neural activity plays little role on the organization of retinal orientation selectivity. Lastly, we use in silico modeling followed by validation experiments to demonstrate that the overrepresented orientation aligns along concentric axes. These results demonstrate that, similar to direction selectivity, orientation selectivity is organized in a functional map as early as the retina.
Microporous Zr-metal-organic frameworks based-nanocomposites for thermoelectric applications
Authors: Ebrahim Asmaa , Ghali Mohsen , El-Moneim A. A. 
Published: June 2024

AbstractIn the area of energy storage and conversion, Metal-Organic Frameworks (MOFs) are receiving more and more attention. They combine organic nature with long-range order and low thermal conductivity, giving them qualities to be potentially attractive for thermoelectric applications. To make the framework electrically conductive so far, thermoelectricity in this class of materials requires infiltration by outside conductive guest molecules. In this study, an in-situ polymerization of conductive polyaniline inside the porous structure of MOF-801 was conducted to synthesize PANi@MOF-801 nanocomposites for thermoelectrical applications. The growth of polyaniline chains of different loadings inside the host MOF matrix generally enhanced bulk electrical conductivity by about 6 orders of magnitude, leading to Seebeck coefficient value of -141 µVK−1 and improved thermal stability. The unusual increase in electrical conductivity was attributed to the formation of highly oriented conductive PANi chains inside the MOF pores, besides host–guest physical interaction, while the Seebeck coefficient enhancement was because of the energy filtering effect of the developed structure. Modulating the composition of PANi@MOF-801 composites by varying the aniline: MOF-801 ratio in the synthesis bath from 2:1 and 1:1 to 1:2 leads to a change in the semiconductor properties from p-type semiconductor to n-type. Among the examined composites with n-type semiconducting properties exhibited the highest ZT value, 0.015, and lowest thermal conductivity, 0.24 Wm−1 K−1. The synthesized composites have better performance than those recently reported for a similar category of thermoelectric materials related to MOF-based composites.
Active juvenile systemic lupus erythematosus is associated with distinct NK cell transcriptional and phenotypic alterations
Authors: Radziszewska Anna , Peckham Hannah , de Gruijter Nina M. , Restuadi Restuadi , Wu Wing Han , Jury Elizabeth C. , Rosser Elizabeth C. , Ciurtin Coziana 
Published: June 2024

AbstractWhile adaptive immune responses have been studied extensively in SLE (systemic lupus erythematosus), there is limited and contradictory evidence regarding the contribution of natural killer (NK) cells to disease pathogenesis. There is even less evidence about the role of NK cells in the more severe phenotype with juvenile-onset (J)SLE. In this study, analysis of the phenotype and function of NK cells in a large cohort of JSLE patients demonstrated that total NK cells, as well as perforin and granzyme A expressing NK cell populations, were significantly diminished in JSLE patients compared to age- and sex-matched healthy controls. The reduction in NK cell frequency was associated with increased disease activity, and transcriptomic analysis of NK populations from active and low disease activity JSLE patients versus healthy controls confirmed that disease activity was the main driver of differential NK cell gene expression. Pathway analysis of differentially expressed genes revealed an upregulation of interferon-α responses and a downregulation of exocytosis in active disease compared to healthy controls. Further gene set enrichment analysis also demonstrated an overrepresentation of the apoptosis pathway in active disease. This points to increased propensity for apoptosis as a potential factor contributing to NK cell deficiency in JSLE.