bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of Resvega in a model of choroidal neovascularization in mice
Authors: RECALDE S , GARCIA‐GARCIA L , FERNANDEZ‐ROBREDO P , IVANESCU A , REDONDO‐EXPOSITO A , MORENO‐ORDUñA M , FERNANDEZ‐GARCIA V , GARCIA‐LAYANA A 
Published: August 2012

AbstractPurpose We aim to assess the effect of Resvega as a source of resveratrol and combined with an anti‐VEGF in a diode laser‐induced choroidal neovascularization (Li‐CNV) model in mice.Methods Sixty C57BL6/J mice underwent a diode Li‐CNV model, and were divided into 4 groups (n=15): Control group: vehicle by oral gavage. NA group: daily oral Resvega (NA). C‐VEGF group: vehicle and intravitreal anti‐VEGF. NA‐VEGF group: NA and intravitreal anti‐VEGF. Oral treatments (100 µL) were administered 10 days before laser until 28 days post‐laser. Intravitreal injections (7 µl) were performed 48 hours after laser. CNV evolution was assessed weekly through fluorescein angiography (FA) for 4 weeks. CD‐31 immunofluorescence was assessed in choroidal flat mounts after sacrifice. Gene and protein expression of VEGF was analyzed with RT‐PCR and western‐blot, respectively. Results were analyzed with SPSS 15.0.Results FA showed a significant decrease in fluorescein leakage from second week in NA and NA‐VEGF groups compared with their respective controls (p<0.05). The lowest CNV area measured by CD31 was observed in NA group compared with control group with statistically significant differences (p<0.05). RT‐PCR and western‐blot analysis showed a significant decrease in VEGF expression in NA and NA‐VEGF groups (p<0.05).Conclusion Our data show that oral Resvega administration reduces CNV area and expression of proangiogenic VEGF expression. These results suggest that Resvega could be considered as potential preventive therapy against CNV. Supported in part by Thea Laboratoires and Grant RETICS RD 07/0062, Ministerio de Ciencia e Innovación.
Ocular effects of combined therapy with pegylated interferon (PegINF) and ribavirin (RBV) in hepatitis C
Authors: ORSKI M , WYLEGALA E , MANKOWSKI W , TARNAWSKA D , WOJCIK L , SMEDOWSKI A , WOWRA B , BLONSKA ‐ FAJFROWSKA B , MUSIALIK J 
Published: August 2012

AbstractPurpose To evaluate ocular effects of combined therapy with pegylated interferon and ribavirin in hepatitis C.Methods 18 patients (36 eyes) received combined therapy based on the presence of HCV antibodies in the serum and positive RT – PCR test results for HCV RNA. Patients were examined at baseline, months 1, 3, 6 after initiation and 6 months after completion of antiviral treatment. Primary outcome was best corrected visual acuity (BCVA) and secondary outcomes were slit lamp examination, intraocular pressure, foveal thickness, and P1 Multifocal Electroretinography( mfERG) amplitude.Results 13 patients (26 eyes) completed the study. 2 of 13 (15%) patients had exacerbation of dry eye syndrome and 2 of 13 (15%) developed retinopathy. Therapy was discontinued in patients with retinopathy with remission of retinal changes after 3 months. No significant changes in other parameters were observed.Conclusion Patients treated with PegINF‐RBV have a potential risk of ocular complications and require a regular ophthalmic examination. We suggest ocular examination and follow up protocol for patients treated with interferon‐ribavarin therapy to limit potential side effects.
Diagnosis of tuberculosis uveitis
Authors: NGUYEN E , BAILLIF GOSTOLI S 
Published: August 2012

AbstractPurpose Tuberculosis uveitis are difficult to diagnose because of their polymorphism of clinical presentations. As a consequence, a diagnostic delay is often observed in this pathology. The goal of this study is to determine the clinical features and the investigations leading to the diagnosis of tuberculosis uveitis.Methods It is a retrospective study at the Saint Roch University Hospital in Nice. We followed eight patients (thirteen eyes) between September 1997 to March 2011, who presented with unilateral or bilateral tuberculosis uveitis.Results A slit‐lamp examination revealed an anterior uveitis in twelve eyes. Six eyes presented granulomatous keratoprecipitates, five had posterior synechia. Funduscopy showed twelve eyes with vitritis, seven eyes presented snowball vitreous opacities, and four eyes were affected by a papillitis. Optical coherence tomography showed a macular oedema in six eyes. Fluorescein angiography revealed five cases of retinal vasculitis. We observed three exsudative retinal detachments, and four choroidal or retinal granulomas. Five tuberculin skin test were performed, and four were positive. Three interferon‐gamma release assays were realized, and were all positive. Six analysis of aqueous humor were negative, one vitreous sample was negative. All the patients were treated with anti‐tuberculosis therapy as well as systemic steroids with a favorable clinical outcome without any recurrences observed.Conclusion Our case series shows that tuberculosis uveitis were mostly anterior granulomatous uveitis, associated with an intermediate uveitis. Some patients presented a posterior affection. Tuberculin skin test and interferon‐gamma release assays were efficient tests while analysis of intraocular fluid was less helpfull.
Danger of research in lasers: about two examples of retinal impacts in senior researchers
Authors: CAMPOLMI N , GRIVET D , THURET G , BERNARD A , GAIN P 
Published: August 2012

AbstractPurpose We report two cases of accidental retinal lesions made by diode and femtosecond lasers in senior researchers in optics.Methods The first case concerned a 29‐year old caucasian woman exposed to a 1053 nm wavelength femtosecond laser (0.5 mW) during mirror alignment. Immediately after exposure, she felt blurry central vision and scotoma in her left eye. Visual acuity was 20/60. Clinical examination showed yellowish dots in foveal region. No treatment was given. Two years later, visual acuity remained low. The second case was a 40‐year old causasian woman exposed to 670 nm wavelength diode laser (3 mW) in both eyes during repeated experiments. The patient had no symptoms. Visual acuity was 20/20 without central scotoma. The fundus revealed several extrafoveal macular white and yellow impacts of different ages. Ten years later, no neovascular complication was observedResults These two different cases illustrate the danger of any type of laser. Thermic or blast effect can caused permanent damage to the retinal pigment epithelium affecting the fixation point with permanent visual acuity decrease. Choroidal infarction has been described in the literature. Main risks are neovascularization and enlargement of the impacts involving the fovea. When patient does not consult immediately after accidental exposition, differential diagnosis of white retinal infiltrates, as multifocal choroiditis, should be ruled out.Conclusion Whatever their skill, researchers and workers exposed to any type of lasers should be reminded the importance of wearing suitable eye protections. Considering the possibility of asymptomatic lesions, a periodical screening remains justified.
Pathologic findings for patients with acute and symptomatic floater
Authors: CHOI MJ 
Published: August 2012

AbstractPurpose To evaluate and establish the rate of pathologic findings for patiens with acute and symptomatic floaterMethods Retrospectively records of 3377eyes(2649 patients) with acute, symptomatic floater who visited Kim’s Eye Hospital from January 1, 2011 to December 31, 2011 were evaluated. Patients with previous retinal detachments resulting from other ocular pathologic features, direct ocular trauma, or previous vitreoretinal, cataract surgery were excluded. Their standard examination included visual acuity, IOP, anterior segment examination, and dilated fundus examination using a slit‐lamp and indirect ophthalmoscopResults The incidence of floater symptom was common in female than male respectively(p<0.05). And the most common cause of floater was posterior vitreous detachment(10.4%). The incidence of retinal tear was 0.8%(28 eyes) and 27eyes of them were undergone barrier laser. The incidence of lattice degeneration was 1.8%(61 eyes) and 36 eyes of them were treated with barrier laser. 3 cases of all showed retinal detachment. 2 cases of them were managed with barrier laser, 1 case was treated with scleral buckling and cryotherapy. And the incidence of retinal hemorrhage and vitreous hemorrhage was 0.4%(15 eyes), 0.02%(8 eyes) each. Other pathologic findings include epiretinal membrane(0.5%, 19 eyes), uveitis(0.4%, 14 eyes), and endophthalmitis(1 eye)Conclusion The study revealed that the pathologic findings of floaters may be encountered: retinal detachment, retinal tears, lattice degeneration, vitreous hemorrhage, retinal hemorrhage, uveitis and endophthalmitis. Patients with an acute, symptomatic floater should be examined closely and if the results of an initial examination are negative for pathologic finding, the necessity of early follow‐up should be needed.
Value of fundus autofluorescence imaging in a rare case of clonazepam associated retinopathy
Authors: MATEO J , JIMENEZ B , ASCASO F , MATEO A , PEREZ D , CASAS P 
Published: August 2012

AbstractPurpose Many unwanted ocular effects have been described after the ingestion of psychotropic drugs. Clonazepam is an anticonvulsant and anxiolytic agent belonging to the family of benzodiazepines. Our aim is to report a case of toxic retinopathy associated with prolonged administration of clonazepam.Methods We present a case of a middle‐aged woman, with no significant ocular or familial ocular history, who complained of bilateral blurred vision and photophobia. She had a long‐lasting anxiety disorder and underwent clonazepam for the previous 8 years. We carried out a complete ophthalmological examination including visual acuity and color vision testing, funduscopy, fluorescein angiography, electrophysiologic retinal testing, optical coherence tomography and fundus autofluorescence (FAF). We found multiple retinal mild depigmentation dots in the posterior pole of both eyes that showed a clear hyperautofluorescence and slightly reduced electrophysiologic responses. Other possible diagnoses were ruled out as multiple evanescent white dot syndrome or macular dystrophy associated with hyperautofluorescence.Results A large variety of drugs may have toxic effects on the human retina. Thus, retinopathy has been shown to be related to high doses of typical antipsychotics, mainly chlorpromazine and thioridazine, but only two cases of retinal toxicity by benzodiazepines have been described. To our knowledge, this is the first reported case of FAF imaging findings in a retinopathy associated with clonazepam.Conclusion Neurologists and ophthalmologists should be aware of the possible retinal toxicity of clonazepam and FAF should be considered as a complementary imaging modality in the diagnosis of toxic or drug‐induced retinopathy.
Dramatic effect of bolus cyclophosphamide in a severe case of lupus retinopathy
Authors: KURUN S , BAUDOT A , MAALOUF T , ANGIOI K 
Published: August 2012

AbstractPurpose To report the dramatic effect of bolus cyclophosphamide in a severe case of lupus retinopathy.Methods A 31‐year‐old woman with active systemic lupus erythematosus (SLE) consulted for asymmetric rapidly progressive decreased visual acuity (8/10 P2 OD, 1/20 P14 OS). Fundus examination disclosed bilateral macular oedema, numerous peripapillary cotton wool spots and hemorrhages suggestive of the diagnosis of lupus retinopathy. Clinical and biological criteria allowed the diagnosis of severe multi systemic SLE with lupus glomerulonephritis. Treatment based on oral 1mg/kg daily steroids and 6 intravenous cyclophosphamide cures (100mg/m2). Rapid improvement in systemic and biological signs of SLE was observed with parallel disappearance of retinal signs. Full recovery of visual acuity was obtained within 6 months.Results Prevalence of SLE varies between 10 and 50 p 100,000. Presence of ophthalmological manifestations is estimated between 5 and 50% of the patients depending on the series, and the most frequent one is lupus retinopathy. First line treatment is usually based on oral corticosteroids. Immunosuppressive drugs may be used as part of a steroid‐sparing strategy or for resistant forms of the disease. In case of severe acute cases, as in our patient, intensive treatment combining steroids and cyclophophamide cures enables regression of retinal signs and improvement of visual acuity, along with clinical and self‐immune and inflammatory tests.Conclusion In severe forms of SLE a treatment combining cyclophosphamide cures and steroids is mandatory to obtain not only improvement of systemic manifestations but also complete visual recovery.
Unilateral Terson syndrome. Outcome after early vitrectomy
Authors: DE LA MATA G , SATUE M , BAMBO M , ARA M , EGEA MC , FERNANDEZ‐PEREZ S , HERRERO R , GARCIA‐MARTIN E 
Published: August 2012

AbstractPurpose To report the clinical features and the results after an early vitrectomy of a case of a Terson syndrome following an aneurysmal subarachnoid hemorrhageMethods 32 years old male with decreased visual acuity (VA) of the right eye (RE) of evolution difficult to determine. As recent precedent a month before stands out a subarachnoid and parenchymal hemorrhage secondary to ruptured aneurysm of the right medial cerebral artery, treated by external ventricular drainage and posterior surgical clipping with satisfactory outcome. The examination revealed visual acuity of light perception in RE and funduscopy shows widespread vitreous haze with impossibility of glimpse the retina, with fibrinous‐looking condensationsResults Suspecting Terson syndrome a pars plana vitrectomy is performed with aspiration of subhyaloid bleeding in the posterior pole. The patient achieved a VA of 0.9 and the funduscopy shows the demarcation zone of ancient bleeding in the posterior poleConclusion Terson's syndrome is the combination of intraocular bleeding and subarachnoid hemorrhage secondary to rupture of an aneurysm. The bleeding can be intraretinal, subretinal or vitreal. It is a commonly underdiagnosed pathology. It is associated with worse neurological prognosis with higher rates of morbidity and mortality. However, vitreous hemorrhage is usually resolved spontaneously within a few months, and generally has good long‐term visual prognosis. But early vitrectomy is indicated in bilateral cases, persistent bleeding or proliferative vitreoretinopathy
Subretinal injection of recombinant tissue of plasminogen activator and intravitreal injection in the management of subretinal hemorrhages secondary to age‐related macular degeneration. A report of eight cases
Authors: DJABAROUTI M , FRISER L , GOBERT F , DE BEKETCH C , YANI N , GICQUEL JJ 
Published: August 2012

AbstractPurpose Complicated forms of AMD are the final stage of a disease leading to deep and permanent visual loss.All current therapeutic advances are opening up real prospects but no consensus has been established despite the efficiency of the subretinal injection of fibrinolytic un macular hematoma.We aimed to assess subretinal injection of rt‐PA associated with anti‐VEGF in the hematoma as a complication of AMD and to establish predictors of efficacy in order to identify target patients.Methods Inclusion criteria were patients with subretinal hematoma as a complication of AMD active for less than 15 days and treated with the same surgical technique: vitrectomy, subretinal injection of rt‐PA, intravitreal gas and anti‐VEGF injections. Data from preoperative clinical exam at 3, 6 and 12 months postoperative were recorded.Results Eight patients with extensive hematoma were included. 62 % patients showed significant improvment at 6 months (p=0,04) contrary to the one year results.Displacement of hematoma was observed in all patients and no complication during the surgery is noted. The mean dose of rt‐PA is 50 µg/ml. All patients received locoregional anesthesia. Postoperative complications were cataract (25%), recurrent hemorrhage (25%), and ocular hypertension (12%). No cases of endophtalmitis or retinal detachment is observed.Conclusion The extensive recent hemorrhage with underlying healthy macula appears to respond to treatment contrary to the old hematoma with pigment epithelium rupture and the hematoma after anti‐VEGF injections responsible of large pigment epithelium detachment.
20 versus 23 Gauge sclerotomies for silicone oil extraction in vitreoretinal surgery
Authors: RADOI C , HAYATE F , DUCASSE A , ARNDT C 
Published: August 2012

AbstractPurpose The visco‐elastic features of silicone oil are a limiting factor transconjunctival vitreoretinal surgery. The flow resistence increases with the reduction of the inner diameter of the extrusion canula. Thise increases the duration of silicone oil extraction. The purpose of this study was to compare 2 surgical procedures for silicone oil extrusion: 20 versus 23 Gauge.Methods A retrospective pilot study compared two groups of patients scheduled for silicone oil extraction. In the first group silicone oil extraction was performed through a 20 Gauge scllerotomy after conjunctival dissection whereas a 25 Gauge tranconjunctival sclerotomy enabled saline infusion. In the second group both infusion and silicone oil extraction was performed through 23 Gayge transconjunctival sclerotomies. The duration of each procedure was the main outcome measure.Results The mean duration of the 23 Gauge procedure was 42 minutes compared with 22 minutes in the combined 20/25 Gauge procedure. Transitory intraoperative hypotonia was encountered in two patients, one in each group. During the post‐operative follow up, a vitreous hemorrhage occurred in one patient of the 23 Gauge procedure group.Conclusion Comparing two surgical procedures for silicone oil extraction, the conjunctival dissection time in the 20/25 Gauge group seems to be largely counterbalanced by the rapidity of the silicone oil extraction through a larger sclerotomy. The use of a combined 20/25 Gauge full transconjunctival procedure could probably reduce furthermore the duration of surgery .
Long term evolution of combined hamartoma of the retina and retinal pigment epithelium: a report of two cases
Authors: CASTRO NAVARRO J , GARCÍA FERNÁNDEZ M 
Published: August 2012

AbstractPurpose To show the long‐term evolution of two cases of Combined Hamartoma of Retina and Retinal Pigment Epithelium (CHRRPE), one managed by vitrectomy, and other managed conservatively.Methods A 46‐year‐old male and a 35‐year‐old female, diagnosed as having a CHRRPE, were observed during four years. One of them underwent pars plana vitrectomy due to an extense associated epiretinal membrane (ERM), and the other patient declined surgery. Full clinical examination, including Best Corrected Visual Acuity (BCVA), funduscopy examination and Optical Coherence Tomography (OCT) was performed.Results For the patient who underwent vitreoretinal surgery, the evolution was initially satisfactory, with anatomic improvement (assesed by funduscopy and OCT examination) and visual acuity stabilization. However, four years later he presented with a complaint of visual loss, and severe macular distorsion was confirmed by OCT. The patient who asked for a conservative management, showed no visual nor funduscopic changes during the follow‐up.Conclusion Vitreoretinal surgery for CHRRPE can improve retinal architecture and visual acuity, but in the long‐term functional recuperation is frequently not possible, with similar visual outcomes to those managed conservatively.
Intraretinal brilliant blue infiltration during membrane limiting intern peeling: a case report
Authors: SAVARY P , LEAL C , MACHKOUR‐BENTALEB Z , CHAISE F , FORTOUL V , DENIS P , KODJIKIAN L 
Published: August 2012

AbstractPurpose Surgical treatment of epiretinal membrane (ERM) have been facilitated by use of dyes such as brilliant blue G (BBG) whose harmlessness by intravitrael injection have been fully reported.Methods We describe the case of a seventy‐two year old female patient addressed for surgical treatment of left idiopathic ERM that caused metamorphopsia and a decrease of visual acuity. Pars plana vitrectomy and ERM peeling staining with BBG was performed.Results During the procedure, an unusual complication occurs: intraretinal BBG infiltration. The area was limited (under a disc diameter) located in macular area, in temporal and superior to the fovea; the infiltration reached all retinal layers according to our OCT images. A defect in retina nerve fiber layer seems to be the origin of that staining. No damage in the field or in fluorescein and indocyanine angiography were observed. A progressive resorption of the staining appeared with atrophy of the inners retinal layers as aftereffect. Visual acuity reached 9/10 Pa2 a month and a half after the surgery.Conclusion In spite of the benefits of vital dyes in vitreoretinal surgery which are widely used, this case remains us the damage that can occur.
Bilateral intermediate uveitis asociated with retinosis pigmentosa
Authors: HERRERO LATORRE R , FERNANDEZ‐PEREZ S , GARCIA‐MARTIN E , SATUE M , IDOIPE M , DE LA MATA G , TORRóN C 
Published: August 2012

AbstractPurpose Retinitis pigmentosa (RP) is a group of inherited dystrophies with great clinical genetic and evolutionary heterogeneity. We report a patient with retinitis pigmentosa who presented a bilateral intermediate uveitis with cystoid macular edema associated and no other systemic disease.Methods A 16 year old man with a history of Retinosis pigmentosa since birth presented blurred vision associated with a bilateral intermediate uveitis. The visual acuity was 0,4, Tyndall ++, and intense vitritis with snowballs in both eyes. All systemic examinations were normal (analytics, autoimmunity and serology tests).Results Patient was treated with orals corticosteroids maintained in decreasing doses. Response to treatment was favorable, but then macular edema appeared. Due to the inability to control uveitis symptoms with steroids, azathioprine was associated and response has been favorable with resolution of macular edema and decreasing inflammation.Conclusion RP includes a large group of degenerative and hereditary diseases that may be associated with a number of ocular complications. Intermediate uveitis is a rare complication described but can cause decreased vision and requiring monitoring and appropriate treatment for their control.