bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dyshidrotic eczema: clinical and epidemiological features and therapy tactics
Authors: Shachnev A. S. , Zhukova O. V. , Kasikhina E. I. 
Published: May 2024

Introduction. Dyshidrotic eczema is a clinical type of chronic eczema, the clinical picture of which is characterized by itchy vesicular or bullous rashes localized on the skin of the palms and/or soles, a tendency to long-term chronic and recurrent course, the development of complications and resistance to therapy. Despite its prevalence and impact on quality of life, treatment of dyshidrotic eczema may be ineffective due to its polyetiology, chronic and recurrent course, and the lack of well-organized randomized controlled studies on the pathogenetic therapy of dyshidrotic eczema.Aim. Conduct an analysis of available sources devoted to the study of dyshidrotic eczema. Provide a description of clinical cases of dyshidrotic eczema and experience with external therapy.Results. The proportion of dyshidrotic eczema among other types of eczema varies from 6 to 31.8%. More than 80% of patients note a negative impact of dyshidrotic eczema on the quality of life. Conducted studies demonstrate a variety of factors predisposing to the onset, among which genetic predisposition, atopy and contact allergy are the main ones. Possible triggers include medications, insolation, humidity, and mycotic sensitization. Dyshidrotic eczema is a long-term and recurrent process with a risk of developing infectious complications. Staphylococcus aureus, Corynebacterium, Streptococcus and Micrococcus are detected in dyshidrotic eczema foci, which must be taken into account in combination therapy. The article presents clinical examples of successful treatment of dyshidrotic eczema localized on the skin of the hands with an external preparation containing a combination of 0.05% betamethasone dipropionate, 0.1% gentamicin sulfate and 1% clotrimazole.Conclusions. Dyshidrotic eczema is a common condition and affects quality of life. Proper diagnosis is essential for effective and efficient treatment. External therapy with the inclusion of a cream (ointment) containing a combination of 0.05% betamethasone dipropionate, 0.1% gentamicin sulfate and 1% clotrimazole gives better results and increases satisfaction with the treatment of patients with dyshidrotic eczema.
Complicated pregnancy and perinatal outcomes in women with type 1 and type 2 diabetes mellitus
Authors: Dudareva Yu. A. , Seroshtanova D. N. 
Published: May 2024

Introduction. Pregestational diabetes mellitus during pregnancy negatively affects the course and outcome of pregnancy, primarily due to the increase in obstetric complications, perinatal morbidity and mortality.Aim. Assessment of obstetric and perinatal complications and the possibility of predicting adverse perinatal outcomes in women with type 1 and type 2 diabetes mellitus.Materials and methods. The study included 132 women. The main group consisted of 79 pregnant women, 41 of them with type 1 diabetes mellitus (group 1A) and 38 with type 2 diabetes mellitus (group 1B) and 53 patients – the control group, whose pregnancy was not accompanied by a violation of the mother’s carbohydrate metabolism.Results. Analysis of the course of pregnancy showed that the complicated course of pregnancy is associated mainly with the presence of placental dysfunction in women with diabetes mellitus, which was detected in 94.9% of cases, in contrast to the control group – 33.3%; p = 0,0001. Polyhydramnios (13.9 ± 1.1%; p = 0.005), diabetic fetopathy (13.9 ± 1.1%; p = 0.005), intrauterine fetal hypoxia requiring maternal assistance was detected in women with diabetes mellitus at 30.4% of cases (p = 0.002). Among the detected cases of cerebral ischemia in newborns born to mothers with type 1 diabetes, 43.5 ± 4.2% of women were prematurely delivered according to indications of fetal distress, and 26.1 ± 3.7% were due to decompensated diabetes in the mother. In women with type 2 diabetes mellitus, delivery according to indications from the fetus among children born with CI – 33.3 ± 3.8 percentage (p = 0.598), cases due to decompensation of the underlying disease and early delivery were not detected (p = 0.001).Conclusions. Thus, complicated pregnancy and adverse perinatal outcomes, despite recent advances in obstetrics and endocrinology, are typical for pregnant women with type 1 and type 2 diabetes mellitus. The management and observation of such patients should be carried out by a multidisciplinary team of specialists specialized in this problem, from the preconception stage to the time of delivery.
Aminobenzoic acid and prospects of its use in ophthalmology practice
Authors: Korneeva A. V. , Loskutov I. A. 
Published: May 2024

Aminobenzoic acid is a biologically active substance widespread in nature, which has a wide range of therapeutic applications as an antiviral, antibacterial, antioxidant, antimutagenic, anticoagulant, fibrinolytic, immunomodulatory, radioprotective agent. As an interferon inducer it has been used for many years in mono- and complex therapy of viral eye lesions: conjunctivitis, keratoconjunctivitis, keratouveitis, including those caused by the herpes virus (Herpes simplex, Herpes zoster), adenoviruses; keratopathies of infectious, post-traumatic and postoperative origin. Taking into account the available information, a new drug has been registered and introduced into clinical practice, the main active ingredient of which is 0.007% aminobenzoic acid – Exinta. However, a number of studies have also shown the effectiveness of аminobenzoic acid in the treatment of neurodegenerative eye diseases by reducing the intensity of oxidative damage by lipid peroxidation products, as well as increasing the activity of transport adenosine triphosphatases in eye tissues. Based on the results obtained, it is recommended to use a 0.007% aminobenzoic acid solution not only for the treatment of viral eye diseases as an interferon inducer, but also in the treatment of uveitis, burns and eye injuries, retinal dystrophies, retinopathy, after ophthalmological operations, inflammatory and dystrophic diseases of the cornea, for keratopathies of various origins, for accommodation disorders, etc. In the given clinical example, 0.007% aminobenzoic acid showed its effectiveness in the lingering course of chronic conjunctivitis in the background of the low effectiveness of other drugs, where with the help of monotherapy it was possible to achieve clinical recovery.
Urate-lowering therapy for gout: Difficulties in goal achieving the and ways to overcome
Authors: Krasivina I. G. , Dolgova L. N. , Dolgov N. V. 
Published: May 2024

Introduction. The effectiveness of gout treatment is assured by achieving a serum uric acid target level, which is currently accepted by most national clinical guidelines and consensus as < 360 µmol/L. Achievement of therapy goals is ensured by modification of patients’ lifestyle and adequate prescription of urate-reducing therapy and often involves a number of difficultiesAim. To analyze the frequency of prescription and success of urate-reducing therapy in patients with gout over a five-year observation period in real clinical practice.Materials and methods. Retrospective evaluation of the management of 104 patients (72 men and 32 women) with gout diagnosed for the first time in 2018, followed up to and including 2023. We analyzed the adequacy of urate-reducing therapy prescription, frequency of arthritis exacerbations, and presence of comorbidities in subgroups achieving or not achieving uric acid target level < 360 µmol/L.Results. 26 people achieved uric acid target level, with a comparable ratio of men and female in subgroups of achieving or not achieving. The fact of achieving uric acid target level was recorded during the first year of observation and was maintained subsequently. Prescription of urate-reducing therapy was registered in 42% of the group, but in only 41% of them it was adequate. Even with adequate prescription of allopurinol, 1/3 of the patients did not achieve uric acid target level. The prescription of an alternative uricostatic agent, febuxostat, was noted in only 9% of patients.Conclusions. Achieving total control in gout in real clinical practice noted in 25%, and urate-reducing therapy was prescribed in 42% of patients. Urate-lowering therapy was prescribed adequate in less than 1/2 of patients. Alternative uricostatic to allopurinol febuxostat was prescribed in less than 1/10 of patients. Opportunity achievement of the urate-reducing therapy goal was determined within the first year from diagnosis gout. If the uric acid target level is not reached within a given period of time, it is necessary analyze the reasons for failure and prescribe or intensify urate-reducing therapy.
Geo-electrostratigraphic assessment of aquifer potential, protectivity, and pliable level of vulnerability within a coastal milieu
Authors: Udosen Ndifreke I. , Ekanem Aniekan M. , George Nyakno J. , Thomas Jewel E. 
Published: May 2024

ABSTRACT

Geo-electro stratigraphic assessments of aquifer potentiality, protectivity, and pliable level of vulnerability within a coastal milieu were undertaken with geo-electrical technology. The vertical electrical soundings were undertaken at 20 locations and the 2D electrical resistivity tomography surveys were undertaken at five locations within the study area. Results obtained from these geo-electrical surveys coupled with hydro-geophysical investigations within the area indicated the presence of four geo-electric layers: motley topsoil, sandy clay, fine sand, and coarse sand. The geo-stratigraphic data assessed groundwater potentiality, protectivity, and vulnerability to contamination with measures of transverse resistance, hydraulic conductivity, transmissivity, hydraulic diffusivity, aquifer storativity, and longitudinal conductance. Geo-hydraulic characterization indicated mean aquifer resistivity of 554.6 Ωm, mean aquifer conductivity of 0.0004 S/m, mean longitudinal conductance of 0.67 Ω−1, mean transverse resistance of 5601.7 Ωm2, mean hydraulic conductivity of 3.5 m/day, mean transmissivity of 283 m2/day, mean storativity of 0.0002, and mean hydraulic diffusivity of 1 × 105 m2/day. The results indicated that the region's groundwater potential ranged from medium to high. Longitudinal conductance values indicated that the aquifer protective capacity ranged from moderate to poor. Geo-electrical technology was therefore found to be an effective methodology for delineating aquifer potentiality, protectivity, and vulnerability within the vulnerable coastal aquifer system.
Treinamento em Ressuscitação Cardiopulmonar Extra-Hospitalar. Comparação Entre Alunos da Área de Humanas e Saúde.
Authors: Cardoso dos Santos Marcos Antônio , Marques dos Santos Sara Cristine , Saldanha dos Santos Pedro Augusto , Dos Santos Silva Marco Aurélio , Tavares Lima Trajano Eduardo , Picone Borges de Aragão Ivana 
Published: May 2024

A parada cardiorrespiratória (PCR) é um evento súbito, com elevada mortalidade, podendo ser revertida em caso de socorro imediato, com técnicas corretas de reanimação cardiopulmonar (RCP). Objetivo foi avaliar o conhecimento e capacitar os alunos das áreas de humanas e saúde sobre técnicas de RCP. Projeto de pesquisa “Avaliação do conhecimento em técnicas de RCP”, Comitê de Ética em Pesquisa 5.902.883, entre 2022 e 2023, com aplicação de questionário antes e após capacitação em RCP, segundo a American Heart Association (AHA). Análise estatística utilizando o teste Qui-quadrado de Pearson ou o teste Exato de Fisher, margem de erro para significância de 5%. Ambos os cursos avaliados demonstraram pouco conhecimento acerca do suporte básico de vida na fase pré-capacitação. Após o treinamento, houve aumento significativo do conhecimento ambos os cursos. A capacitação é uma forma de aumentar o conhecimento e engajamentos do público para atuar frente a emergências extra hospitalares.
Navegação em oncologia: atuação do enfermeiro navegador na assistência ao paciente com câncer
Authors: Araújo Jessica dos Santos , Abreu Wanessa Oliveira de , Santos Daiana Alves dos , Santos Adyverson Gomes dos , Paixão Wallace Henrique Pinho da , Silva Jorge Luiz Lima da 
Published: May 2024

Introdução: as doenças crônicas não transmissíveis (DCNT) são mundialmente as mais incidentes com destaque do câncer, que demanda tratamento contínuo e integral, configurando a navegação em oncologia. Metodologia: refere-se a uma revisão integrativa de literatura, ou seja, uma interpelação que objetiva a junção de reflexões com base na produção de uma perspectiva sobre um determinado tema em estudo. Resultados: a navegação do paciente é organizada em nove princípios teóricos que auxiliam o enfermeiro em suas atribuições voltadas à oncologia, estabelecendo um perfil de coordenação, liderança, comunicação, educação em saúde, orientação e informação. Ademais, o usuário de saúde acometido pelo câncer é parte integrante desse processo de recuperação e promoção da saúde, à medida que estabelece uma conexão com o profissional. Discussão: em relação às lacunas no cuidado oncológico e seus efeitos no plano de tratamento, os enfermeiros navegadores têm como função o gerenciamento do cuidado para pacientes recentemente diagnosticados com câncer. Considerações finais: infere-se, portanto, que a navegação em oncologia com a pessoa com câncer é caracterizada pelo vínculo profissional/paciente e no abastecimento de informações sobre a doença a fim de propiciar o enfrentamento por parte do paciente.
Palavras-chave: Enfermagem; Navegação de Pacientes; Oncologia.
COVID-19 - Revisão das manifestações cardiovasculares
Authors: Francisco Gabriel Katiuscia de Oliveira , Paz Chao Bárbara Mendez , Ivanski Fernanda , Fermino Bárbara Luisa , Nascimento Marcieli Borba do , Carraro Emerson 
Published: May 2024

Introdução: A Doença do Coronavírus de 2019 (COVID-19) progrediu rapidamente para uma emergência de saúde mundial. No entanto inicialmente suas complicações eram associadas ao sistema respiratório, muito ainda é desconhecido acerca das suas manifestações extrapulmonares. Deste modo, o estudo buscou compreender a interação entre a COVID-19 e manifestações cardíacas. Materiais e Métodos: Estudo descritivo do tipo revisão, realizada de acordo com a estratégia PICOS para elucidar o objetivo do trabalho, entre os meses de janeiro a maio de 2023. Resultados e Discussão: Foram incluídos 7 estudos, de 2020 a 2022, considerados pertinentes de acordo com os critérios de elegibilidade segundo o objetivo do presente trabalho. As complicações cardíacas associadas à COVID-19 incluem lesão miocárdica, insuficiência cardíaca, arritmias, miocardite, infarto agudo do miocárdio, associados à importantes alterações em exames laboratoriais bem como à comorbidades. Considerações finais: Ficou evidente a relevância da problemática no contexto da COVID-19, bem como se ressalta a necessidade de mais estudos, a fim de que os mecanismos que levam as alterações cardíacas possam ser mais bem elucidados e dessa forma contribuírem para a prática clínica e melhoria da qualidade de vida dos pacientes acometidos.
Palavras-Chave: COVID-19; Diagnóstico; Manifestações Cardíacas; Complicações Cardíacas.
Multimorbidity and its Associated Factors in Korean Shift Workers: Population-Based Cross-Sectional Study
Authors: Hong Hye Chong , Kim Young Man 
Published: May 2024

Background
Multimorbidity is a crucial factor that influences premature death rates, poor health, depression, quality of life, and use of health care. Approximately one-fifth of the global workforce is involved in shift work, which is associated with increased risk for several chronic diseases and multimorbidity. About 12% to 14% of wage workers in Korea are shift workers. However, the prevalence of multimorbidity and its associated factors in Korean shift workers are rarely reported.

Objective
This study aimed to assess multimorbidity prevalence, examine the factors associated with multimorbidity, and identify multimorbidity patterns among shift workers in Korea.

Methods
This study is a population-based cross-sectional study using Korea National Health and Nutrition Examination Survey data from 2016 to 2020. The study included 1704 (weighted n=2,697,228) Korean shift workers aged 19 years and older. Multimorbidity was defined as participants having 2 or more chronic diseases. Demographic and job-related variables, including regular work status, average working hours per week, and shift work type, as well as health behaviors, including BMI, smoking status, alcohol use, physical activity, and sleep duration, were included in the analysis. A survey-corrected logistic regression analysis was performed to identify factors influencing multimorbidity among the workers, and multimorbidity patterns were identified with a network analysis.

Results
The overall prevalence of multimorbidity was 13.7% (302/1704). Logistic regression indicated that age, income, regular work, and obesity were significant factors influencing multimorbidity. Network analysis results revealed that chronic diseases clustered into three groups: (1) cardiometabolic multimorbidity (hypertension, dyslipidemia, diabetes, coronary heart disease, and stroke), (2) musculoskeletal multimorbidity (arthritis and osteoporosis), and (3) unclassified diseases (depression, chronic liver disease, thyroid disease, asthma, cancer, and chronic kidney disease).

Conclusions
The findings revealed that several socioeconomic and behavioral factors were associated with multimorbidity among shift workers, indicating the need for policy development related to work schedule modification. Further organization-level screening and intervention programs are needed to prevent and manage multimorbidity among shift workers. We also recommend longitudinal studies to confirm the effects of job-related factors and health behaviors on multimorbidity among shift workers in the future.
Web-Based Group Conversational Intervention on Cognitive Function and Comprehensive Functional Status Among Japanese Older Adults: Protocol for a 6-Month Randomized Controlled Trial
Authors: Miura Kumi Watanabe , Kudo Takashi , Otake-Matsuura Mihoko 
Published: May 2024

Background
Social communication is a key factor in maintaining cognitive function and contributes to well-being in later life.

Objective
This study will examine the effects of “Photo-Integrated Conversation Moderated by Application version 2” (PICMOA-2), which is a web-based conversational intervention, on cognitive performance, frailty, and social and psychological indicators among community-dwelling older adults.

Methods
This study is a randomized controlled trial with an open-label, 2-parallel group trial and 1:1 allocation design. Community dwellers aged 65 years and older were enrolled in the trial and divided into the intervention and control groups. The intervention group receives the PICMOA-2 program, a web-based group conversation, once every 2 weeks for 6 months. The primary outcome is verbal fluency, including phonemic and semantic fluency. The secondary outcomes are other neuropsychiatric batteries, including the Mini-Mental State Examination, Logical Memory (immediate and delay), verbal paired associates, and comprehensive functional status evaluated by questionnaires, including frailty, social status, and well-being. The effect of the intervention will be examined using a mixed linear model. As a secondary aim, we will test whether the intervention effects vary with the covariates at baseline to examine the effective target attributes.

Results
Recruitment was completed in July 2023. A total of 66 participants were randomly allocated to intervention or control groups. As of January 1, 2024, the intervention is ongoing. Participants are expected to complete the intervention at the end of February 2024, and the postintervention evaluation will be conducted in March 2024.

Conclusions
This protocol outlines the randomized controlled trial study design evaluating the effect of a 6-month intervention with PICMOA-2. This study will provide evidence on the effectiveness of social interventions on cognitive function and identify effective target images for remote social intervention.

Trial Registration
UMIN Clinical Trials UMIN000050877; https://tinyurl.com/5eahsy66

International Registered Report Identifier (IRRID)
DERR1-10.2196/56608
KRIMINALITAS, HEGEMONI, DAN POLITIK: PREMANISME DI YOGYAKARTA PADA MASA ORDE BARU
Authors: Ibrahim Julianto 
Published: May 2024

Indonesian democracy, despite being praised as an example of democracy in Muslim majority country, has been marked with the important role of non-state actors in influencing the social, economic, and political conditions of a society that are outside the government structure. One of the actors who play an important role in influencing the condition of society is the presence ofthugs and their acts of thuggery. This pattern of politics can be traced back to the ear of New Order. This research attempts to reveal and describe the actions carried out by thugs and their impact on the lives of the people of Yogyakarta during the New Order era. The method usedis the oral history method by interviewing the actors of non-state politics in Yogyakarta, primarily prominent young paramilitary or thug groups including Joxzin, Qizruh, Pemuda Pancasila and their relations with major political parties at that time, Golkar, PDIP and PPP. Thisresearch reveals that during the New Order era, thugs in Yogyakarta collaborated and cooperated with political forces. Political power utilizes thugs as a force that can suppress political opponents with violence and as a means of gaining votes in elections. Meanwhile, thugsjoin political forces with the intention of seeking political protection for their criminal acts and as a means of pursuing a career for a better future. Golkar in Yogyakarta used the mass organization Pemuda Pancasila (PP) as an element that could be used to suppress and intimidatepolitical opponents. Meanwhile, PPP and PDI used their party’s laskars (paramilitary wing) in securing and dealing with the violence they faced. The main strength of the laskars in PPP and PDI actually came from the wild youth organizations, namely Joxzin and Qizruh. For the twogroups, known for their violent repertoires, this presents an alternative to express themselves and a place to find identity. When the New Order rule ended in 1988, Qizruh leaders joined PP which meant supporting Golkar, and several other leaders chose to support PDI. Meanwhile,Joxzin’s elders had many careers as the main force of the laskars in PPP.