bluuebunny/crossref_metadata_2025_split huggingface dataset:
Development of a nomogram to predict in-hospital mortality of lower extremity deep vein thrombosis patients in intensive care unit
Authors: Duan Hongwei , Qi Jing , Sun Chuanzheng 
Published: June 2024

Abstract

Object: This study aimed to analyze factors influencing the survival of patients with lower extremity deep vein thrombosis (LEDVT) complicated during intensive care unit (ICU) admission and develop a nomogram for predictive use.
Materials and Methods: Retrospective analysis of 482 LEDVT cases in ICU at Third Xiangya Hospital (Feb 2017-Nov 2022). Data on demographics, comorbidities, treatments, vital signs, and lab indicators (within 24 hours of admission) were collected. Patients were randomly divided into training and test sets (3:1 ratio). Univariate and multivariate analyses were performed using SPSS and RStudio. Logistic regression and nomogram models were constructed and validated.
Results: Intubation/Tracheotomy, vasopressor usage, age, lymphocytes and lactate were identified as independent risk factors. rivaroxaban usage and enoxaparin usage were identified as protective factors. The nomogram had area under the curve(AUC) of 0.855 (training set) and 0.775 (testing set). Decision curve and clinical impact analyses demonstrated the nomogram's clinical utility within specific probability ranges.
Conclusion: The developed nomogram accurately predicts in-hospital mortality of LEDVT patients in the ICU, providing valuable insights for clinical decision-making and patient management.
Parenting Before and During the COVID-19 Pandemic: Longitudinal Findings for Child Mental Health Outcomes
Authors: Benstead Michelle L. , King Gabriella L. , Westrupp Elizabeth M. 
Published: June 2024

Abstract

Adult mental health issues increased during the COVID-19 pandemic, especially for parents. Few studies have investigated associations between parents’ pre-pandemic mental health issues and parents’ emotion-related parenting practices during the pandemic, as well as subsequent child mental health outcomes. The present study aimed to: 1) investigate associations between pre-existing parent mental health issues (2019) with long-term child mental health issues (2021), via changes in emotion-related parenting practices during the COVID-19 pandemic (2020); and 2) test whether COVID-19 pandemic-related environmental stressors during 2020 and 2021 (e.g., loss of employment) exacerbated associations between emotion-related parenting practices and child mental health problems. Data were drawn from (name of study). Parents of children aged 4–9 years (N = 1,046) completed online self-report surveys. A path analysis model with a moderated mediation was tested in Mplus. Parent mental health issues at Time 1 was associated with lower levels of emotion coaching practices at Time 2, and emotion dismissing practices at Time 2 was associated with higher levels of children’s parent-reported behavioral problems at Time 3. There was no evidence to support mediation effects, or a moderating influence of COVID-19 environmental stressors. Findings highlight the importance of providing parents mental health support, in order to facilitate emotion coaching parenting practices. Further, the provision of evidence-based and flexibly-delivered parenting support in future pandemics/crisis events may better support parents’ mental health and parenting, and reduce the impact on child mental health problems.
Knowledge and practices of hand hygiene among healthcare workers in three urban hospitals in Bobo-Dioulasso city, 2022 (Burkina Faso)
Authors: Hema Arsène , Some Arsène , Traoré Marthe Louise , Sanou Soufiane , Kafando Victorien , Poda Armel , Meda Clément , Savadogo Léon 
Published: June 2024

Abstract

Background
The hands of healthcare workers are the major source of healthcare-associated infection transmission. Hand hygiene (HH) remains the most effective measure for preventing such infections. This study aimed to assess knowledge, technical mastery and compliance with HH among healthcare workers in three hospitals in Bobo Dioulasso city.
Methods
A multicenter cross-sectional study was conducted from May 5th to July 3rd, 2022, in 2 district hospitals (DO et Dafra) and the Sourô Sanou Teaching Hospital. Data collection involved the use of a questionnaire on knowledge (WHO, 2009), a WHO direct observation tool for HH compliance (WHO, 2009c) and an observation grid completed by trained investigators to assess HH technique and compliance. Data analysis was performed using Stata 13. We used multilevel linear and logistic regression to analyze the associations between HH knowledge scores, HH compliance, and participants’ characteristics.
Results
In total, 175 participants were included, and a total of 1701 observations were made. The participants included 24.6% physicians, 60.0% nurses, 12.0% midwives and 3.4% hospital hygiene technicians. The median age of the study participants was 39 years (IQR 27–46), and the median work experience was 10 years (IQR 5–15). The median HH knowledge score was 8 out of 15 points (IQR 7–9). Only 40.7% of participants adhered to the correct HH technique, and the compliance rate for HH following WHO indications was 40.3%. The predictors of good knowledge scores on HH were young age, female gender, workplace, seniority in the profession and participation in HH training. The predictors of HH compliance were age between 40 and 49 years (OR = 2.1; CI = 1.2–3.8), surgery ward of Do (OR = 3.3; CI = 2.0–5.5), and participation in HH training (OR = 1.4; CI = 1.1–1.9).
Conclusions
Healthcare workers’ knowledge, technical mastery and HH compliance were low. It is therefore necessary to strengthen compliance with HH through implementation training programs and increased awareness initiatives.
The PLET (Portable Laparoscopic Trainer) Study: A Randomized Controlled Trial of Home- versus Hospital-based Surgical Training
Authors: Kuemmerli Christoph , Linke Katja , Daume Diana , Germann Nicolas , Peterli Ralph , Müller-Stich Beat , Klasen Jennifer M. 
Published: June 2024

Abstract

Purpose
The purpose of this study was to assess the effect of training with a personal, portable laparoscopic endo-trainer (PLET) on residents’ laparoscopic skills.
Methods
The study took place at a tertiary-care academic university hospital in Switzerland. All participants were randomized to either a home- or hospital-based PLET training group, and surgical skill performance was assessed using five laparoscopic exercises. 24 surgical residents, 13 females and 11 males, were enrolled at any training stage. Nine residents completed the assessments. Endpoints consisted of subjective and objective assessment ratings as well as exercise time and qualitative data up to 12 weeks. The primary outcome was the difference in exercise time and secondary outcomes included performance scores as well as qualitative data.
Results
The hospital-based training group performed exercises number 1, 3 and 4 faster at 12 weeks than at baseline (p = .003, < .001 and .024). Surgical skill performance was not statistically significantly different in any of the endpoints between the hospital- and home-based training groups at 12 weeks. Both the subjective and objective assessment ratings significantly improved in the hospital-based training group between baseline and 12 weeks (p = .006 and .003, respectively). There was no statistically significant improvement in exercise time as well as subjective and objective assessment ratings over time in the home-based training group. The qualitative data suggested that participants who were randomized to the hospital-based training group wished to have the PLET at home and vice versa. Several participants across groups lacked motivation because of their workload or time constraints, though most believed the COVID-19 pandemic had no influence on their motivation or the time they had for training.
Conclusion
The PLET enhances laparoscopic surgical skills over time in a hospital-based training setting. In order to understand and optimize motivational factors, further research is needed.
Trial registration:
This trial was retrospectively registered on clinicaltrials.gov (NCT06301230).
Effects of fructose-exposed human mesangial cells on classical and alternative enzyme activities of Renin-Angiotensin System modulating peptides generation
Authors: Yokota Rodrigo , Stoll Danielle , Oliveira Lilian Caroline Gonçalves , Jara Zaira Palomino , Gomes Andréia Cristina Febba , Casarini Dulce Elena 
Published: June 2024

Abstract

Historically, proteolytic enzymes have been responsible for breaking peptide bonds between amino acids, catalyzing various reactions in metabolic pathways, and are important for maintaining and regulating these pathways. Recent studies have shown that the levels of various enzymes in the Renin-Angiotensin System (RAS), includingangiotensin-converting enzymes 1 and 2 (ACE and ACE2), neutral endopeptidase (NEP), chymase, renin, and cathepsin D, are altered in animal models subjected to fructose or glucose overloaded diets. Fructose metabolism leads to urate formation, which can cause tubular damage, inflammation, and hemodynamic changes. This study evaluated the modulation of peptide generation by classical and alternative RAS enzymes under the influence of fructose in immortalized human mesangial cells (MCs). Cells stimulated with 5mM and 30mM fructose showed decreased intracellular ACE activity and increased extracellular ACE activity, indicating the formation of Ang II. Increased intracellular Ang I result in increased renin and Cathepsin D activities, mediated by the stimulation of gene transcription enzymes. The activity of ACE2/NEP, responsible for the formation of Ang (1–7), counterbalances the actions of Ang II and protects against pathophysiological alterations caused by fructose. Intracellular chymase showed a higher expression than ACE, suggesting its involvement in the generation of increased intracellular Ang II, which may have an intracrine action. Fructose modulated the Ang II and Ang (1–7) axes in both intra-and extracellular compartments, demonstrating a balance between classical and alternative pathways and protecting MCs against matrix expansion and inflammation that contribute to glomerular sclerosis.
Investigating RFTN1 as a Potential Immune System Inhibitor in the Tumor Microenvironment of Breast Cancer to Enhance Tumor Immune Escape
Authors: Xin Hongbin , Zhang Mingzhu , Miu Linrui , Zhou Lin , Li Zhenghang , Tang Lingfeng 
Published: June 2024

Abstract

Background
Immune checkpoint inhibitors have been extensively utilized in treating breast cancer patients, leading to improved prognoses. For patients with negative checkpoint responses, there is a pressing need to identify alternative therapies to improve outcomes.
Materials and Methods
We used WGCNA in muti-place metastasis samples to find the lymph node metastasis related gene RFTN1. Consensus cluster show the different subtype with significant pathway changes and immune cells differences. We used CellChat estimated the different interactions of cells in single cell data. We used hdWGCNA and irGSEA to identify the changes between different RFTN1expression groups.
Results
We identified a gene, RFTN1, that is closely associated with lymph node metastasis, a critical early step in breast cancer spread. Immune infiltration analysis suggested that RFTN1 might be involved in regulating the immune system. Single-cell RNA sequencing revealed that samples with higher RFTN1 expression had increased proportions of CD8+ and CD4+ T cells, albeit the overall proportions were lower. These samples also showed different interactions between T cells and other cells, indicating a greater reception of chemotactic factors (CFs) in samples with higher RFTN1 expression. It appears that RFTN1 may facilitate T cell receptor binding to CFs, thereby enhancing T cell activation in the tumor microenvironment (TME).
Conclusion
This study proposes a novel approach to modulating T cells in the TME and offers an alternative to traditional immune checkpoint inhibitor therapies for treating BC. RFTN1 is related to the CFs receptor transportation in CD4+ T cells and CD8+ T cells, which may activate the anti-tumor immunity system in TME.
Access to trimodal therapy in muscle-invasive bladder cancer is lower in unmarried females
Authors: Vitucci Kira , Siech Carolin , Baudo Andrea , Jannello Letizia Maria Ippolita , Angelis Mario , Bello Francesco , Goyal Jordan A. , Tian Zhe , Saad Fred , Shariat Shahrokh F. , Longo Nicola , Carmignani Luca , Cobelli Ottavio , Briganti Alberto , Kluth Luis A. , Chun Felix K. H. , Karakiewicz Pierre I. 
Published: June 2024

Abstract

Objective:
Trimodal therapy (TMT) is guideline-recommended for localized muscle-invasive urothelial carcinoma of the urinary bladder (UCUB). Married status represents an important determinant of treatment use in many primaries. The importance of married status is unknown in the context of TMT for localized muscle-invasive UCUB and was addressed in the current study.
Methods:
We relied on the Surveillance, Epidemiology, and End Results database (2004–2020) to identify patients with localized muscle-invasive UCUB. Univariable logistic regression models were fitted. Additionally, temporal trends were plotted.
Results:
Overall, 28,035 patients with localized muscle-invasive UCUB were identified. Of those, 7,112 (25%) were female and 20,923 (75%) were male. Of females, 2,389 (34%) were married. Of males, 13,671 (65%) were married. The rates of TMT were 14% in both married females and males and 13% in both unmarried females and males. Married females differed from unmarried females regarding age and race/ethnicity. Prior to multivariable adjustment for age and race/ethnicity, no significant association existed between married status and TMT use in females (p = 0.2). However, after multivariable adjustment, a 1.2-fold (p = 0.02) higher rate of TMT was recorded in married females vs. their unmarried counterparts. Finally, no association between married status and TMT use was recorded in males either prior to or after multivariable adjustment.
Conclusion:
Unmarried female patients may be at risk of lower TMT access compared to their married counterparts. Consequently, TMT should be given particularly thorough consideration in unmarried female patients to avoid suboptimal TMT access.
Effects of gait training using trunk IMU-Vibrotactile feedback on gait kinematic of Through Knee amputee: primarily results
Authors: Hussain Rufaida , Zabach Bareaa , Hmra Doaa 
Published: June 2024

Abstract

The use of wearable sensors integrated with vibrotactile feedback enhances patient's awareness and control of their movements during gait training. Monitoring trunk angle during gait training can lead to improve gait patterns and reduce risk of falls. This paper presents a case study of a female participant with through knee amputation that underwent on gait training using a developed system. The system consists of a single IMU (inertial measurement unit) attached to her trunk and integrated with vibrotactile feedback. Before and after training session, Gait analysis was done, then gait symmetry index, time-distance parameters, and kinematics of lower limb and trunk were measured. The results show improvements after training in time-distance parameters and symmetry index. In addition to reducing gait deviations (lateral trunk bending and vaulting). Further research and larger studies are warranted to validate these findings and explore the full potential of this innovative technology in enhancing different levels of amputee rehabilitation.
Impact of a Multidisciplinary Service Line and Program for Transcatheter Device Closure of the Neonatal Ductus Arteriosus
Authors: Ligon R. Allen , Bhombal-Kazi Shazia , Adamson Marissa , Hash Sarah , Kim Dennis W. , LeFevre Ashley S. , Long Justin , McLaughlin Sarah , Mills Marcos , Roddy Katie , Tucker Lucas , Samai Cyrus , Piazza Anthony , Hamrick Shannon E. 
Published: June 2024

Abstract

Objective–
Outline a quality initiative establishing an institutional service line for neonatal transcatheter device closure of the patent ductus arteriosus (TDC-PDA).
Study Design –
A retrospective descriptive observational study surrounding programmatic approach to TDC-PDA in premature neonates with process measure spanning education, implementation, referral, and post-procedural care. Metrics tracked pre- and post-program creation with statistical analyses performed.
Results –
Neonatal TDC-PDA referrals increased exponentially since program inception (n=13 in year prior; n=42 year 1; n=74 year 2), especially in patients weighing less than 1.3 kg (12.5%; 55%; 50%), and was associated with an increased procedural success rate (81%; 95%; 99%). Procedural checklist creation decreased procedural “out of isolette” time (median 93 minutes; 59; 52), and procedural-related complication or clinical sequelae (19%; 12%; 4%).
Conclusion –
A multidisciplinary service line and program dedicated to neonatal TDC-PDA can result in a significant increase in referrals as well as procedural efficacy and safety for this medically fragile population.
In vitro acaricidal properties of extracts from Carica papaya seeds and Chrysanthemum roseum leaves against Rhipicephalus microplus
Authors: Dhabale Ankush Ravishekhar , Macha Vijay , Jadhav Nitin Dadarao , Choudhary Sachin Kumar , Sharma Anil Kumar , Gudewar Jagdish Ganpat , Narawade Mahima Ramesh , Jadhav Suresh Gulabrao , Chepte Sharad Dyandev , Chigure Gajanan Madhavrao 
Published: June 2024

Abstract

The present study aimed to assess the adulticidal and larvicidal efficacy of chloroform, methanol, and hexane extracts obtained from the Chrysanthemum roseum (leaves) and the Carica papaya (seeds) against Rhipicephalus microplus ticks. The percentage of extractability for all the extracts varied between 1.5% and 25%. The hexane extract of C. roseum showed a mortality rate ranging from 6.66 ± 6.66% to 100.00 ± 0.00% at doses ranging from 0.62–5%. An impact on the oviposition capacity of the treated ticks, resulting in a significant reduction of 90.15 ± 6.460% in oviposition at a concentration of 2.25% was also observed. The methanol extract of C. roseum exhibited a higher concentration of anti-tick action and did not demonstrate a significant influence on the reproductive potential of the treated ticks. A mortality rate of 33.33 ± 17.63 to 93.33 ± 6.67% for treated ticks during 24 hrs. of treatment, was observed at concentration range of 5 to 12.5% of hexane extract of Carica papaya, Furthermore, the extract also resulted in the suppression of egg-laying (98.72 ± 1.27%) at 12.5%. Against larvae, the extract exhibited equivalent efficacy and LC50 and LC90 values of 0.003% and 0.012% for LIT, and 0.08% and 0.28% for LPT, respectively.
Study on Stability Evaluation of Goaf Based on AHP and EWM—Taking the Northern New District of Liaoyuan City as an Example
Authors: Wen zhou , zhang yichen , Zhang jiquan 
Published: June 2024

Abstract

This study evaluated the stability of the goaf in the northern new district of Xi'an District, Liaoyuan City, Jilin Province. Fourteen indicators were selected from three aspects: specifications of the goaf, ecological and geological environment, and mining conditions to make the evaluation of the stability of the goaf more comprehensive. Based on improved game theory, two weighting methods of AHP-EWM (Analytic Hierarchy Process and Entropy Weight Method), were used to calculate the weights, and finally, Mapgis and Arcgis was used to intuitively understand the ground stability of the study area. According to the threshold value, the stability of the study area was divided into three types: stable, basically stable, and unstable, and the results show that the stability of the study area is generally at the lower middle level. The stability grading of the goaf in the northern new area provides a scientific basis for establishing reasonable urban planning in the future and protects people's lives and properties more effectively.
Genetic algorithm-based parameter identification of Johnson- Cook constitutive model for 304 stainless steel
Authors: Jiang Xinyang , Ding Jinfu , Wang Chengwu , Shiju E , Hong Ling , Yao Weifeng , Wang Huadong , Zhou Chongqiu , Yu Wei 
Published: June 2024

Abstract

Addressing the significant discrepancy between actual experimental cutting force and its predicted values derived from traditional constitutive model parameter identification methods, a reverse identification research of the Johnson-Cook (J-C) constitutive model for 304 stainless steel was conducted via genetic algorithm. Considering actual cutting zone and the influence of feed motion on the rake (flank) angle, an unequal division shear zone model was established to implement the theoretical calculation for shear zone stress. Through cutting experiments, the spindle speed was negatively correlated with the cutting force at first, and then became positively correlated; The empirical formula (EXP model) for turning force was corrected, revealing that the EXP model was unable to provide optimal predicted values for cutting force. The influence of the J-C constitutive parameter C on the cutting morphology was firstly investigated through simulation analysis, and determined an appropriate value for C, then obtained the precise values for the other four constitutive parameters by genetic algorithm. Moreover, the simulated values of cutting force in JC1 model (obtained from the Split Hopkinson Pressure Bar test) and JCM model (the improved model using genetic algorithm) were obtained by three-dimensional (3-D) simulation via FEM software. The results indicated that, the maximum error between actual experimental cutting force and its simulated values (by JCM model) was 14.8%, with an average error of 6.38%. These results outperformed the JC1 and EXP models, suggesting that the JCM model identified via genetic algorithm was more reliable.
Socioeconomic Status and Sleep Duration Among a Representative Sample of US Adults
Authors: Wetzel Sarah , Bilal Usama 
Published: June 2024

Abstract

Background
Sleep is a crucial determinant of physical and mental health outcomes, and insufficient sleep is highly prevalent among United States adults. Although some risk factors of poor sleep have been extensively studied, including substance use, age, health behaviors, and others, the associations between socioeconomic status (SES) and sleep remain inconclusive. There is limited evidence on SES and sleep duration among the US adult population. This study analyzed the relationships between three SES indicators (poverty, education, and food security), and sleep duration.
Methods
We used responses from the 2017-March 2020 National Health and Nutrition Examination Survey (NHANES). Respondents younger than 25 years old were excluded. Sleep duration was classified using self-reported sleep time and stratified by work vs non-workdays. SES was operationalized using three indicators: poverty-income ratio, educational attainment, and food security status. We imputed missing exposure using multiple imputation. Weighted Poisson regression models with robust standard errors were used to calculate the crude and adjusted prevalence ratios for insufficient sleep duration on workdays and non-workdays separately by each of the three SES indicators.
Results
We included a total of 8,427 individuals. In the adjusted model, participants with lower income, educational status, and food security had significantly higher prevalence of insufficient sleep duration on both workdays and non-workdays. For example, low-income individuals had 1.24 (95% CI 1.13 to 1.36) and 2.08 (95% CI 1.85 to 2.34) higher prevalence of insufficient sleep as compared to high income individuals on workday and non-workdays. In general, we found more extreme prevalence ratios for the non-workday than for the workday outcome.
Conclusion
Socioeconomic status is significantly associated with sleep duration in the US adult population. Lower SES correlates with increased prevalence of insufficient sleep duration, which has implications for the overall wellbeing of US adults with lower SES. Targeted interventions and further research are needed to reduce this disparity.