bluuebunny/crossref_metadata_2025_split huggingface dataset:
Relation of mucous membrane alterations to oral intake during the first year after treatment for head and neck cancer
Authors: Pauloski Barbara Roa , Rademaker Alfred W. , Logemann Jerilyn A. , Lundy Donna , Bernstein Michelle , McBreen Carrie , Santa Daphne , Campanelli Angela , Kelchner Lisa , Klaben Bernice , Discekici‐Harris Muveddet 
Published: August 2010

AbstractBackground.Acute oral mucositis is associated with pain and impaired swallowing. Little information is available on the effects of chronic mucositis on swallowing.Methods.Sixty patients treated for cancer of the head and neck were examined during the first year after their cancer treatment. Oral mucosa was rated with the Oral Mucositis Assessment Scale. Stimulated whole‐mouth saliva, oral pain rating, percent of oral intake, and 2 subscales of the Performance Status Scale for Head and Neck (PSS‐HN) cancer were also collected.Results.Mucositis scores and pain ratings decreased over time while functional measures of eating improved over time. Reduction in chronic mucositis was correlated with improved oral intake and diet.Conclusion.Lack of association with pain was attributed to the absence of ulcerations. Continued impairment of oral intake during the first year posttreatment may be related to oral mucosal changes and other factors. © 2010 Wiley Periodicals, Inc. Head Neck, 2011
Dexamethasone prophylaxis before thyroidectomy to reduce postoperative nausea, pain, and vocal dysfunction: A randomized clinical controlled trial
Authors: Feroci Francesco , Rettori Marco , Borrelli Andrea , Lenzi Elisa , Ottaviano Alessandra , Scatizzi Marco 
Published: August 2010

AbstractBackground.The objective of this 2‐arm, double‐blind, randomized, controlled study was to assess the effects of a preoperative single dose steroid on postoperative nausea and vomiting (PONV), pain, and vocal function after thyroidectomy for benign disease.Methods.We randomized 102 patients into 2 groups from January to December 2009: (1) treatment with 8 mg/2 mL of dexamethasone and (2) treatment with 2 mL NaCl 0.9%, both administered intravenously before anesthesia.Results.The severity of nausea and the need for antiemetic drugs were reduced in patients receiving dexamethasone (p = .0001). Dexamethasone patients reported significantly less pain (p = .008); the need for analgesic drugs was lower in the dexamethasone group (p = .048). No differences were noted with regard to subjective voice analysis (p = .693).Conclusion.Dexamethasone (8 mg IV) is a safe and effective method to reduce PONV and pain after thyroid resection and should be used routinely. © 2010 Wiley Periodicals, Inc. Head Neck, 2011
Changes in nutritional status and dietary intake during and after head and neck cancer treatment
Authors: Jager‐Wittenaar Harriët , Dijkstra Pieter U. , Vissink Arjan , Langendijk Johannes A. , van der Laan Bernard F.A.M. , Pruim Jan , Roodenburg Jan L.N. 
Published: August 2010

AbstractBackground.The purpose of this study was to test whether nutritional status of patients with head and neck cancer changes during and after treatment.Methods.Nutritional status (including body weight, lean mass, and fat mass) and dietary intake were assessed in 29 patients with head and neck cancer. Patients were assessed 1 week before, and 1 and 4 months after treatment (radiotherapy, either alone or combined with chemotherapy or surgery).Results.During treatment, body weight (−3.6 ± 5.3 kg; p = .019) and lean mass (−2.43 ± 2.81 kg; p = .001) significantly declined. Patients with sufficient intake (≥35 kcal and ≥1.5 grams protein/kg body weight) lost less body weight and lean mass than patients with insufficient intake (mean difference, −4.0 ± 1.9 kg; p = 0.048 and −2.1 ± 1.0 kg; p = .054, respectively). After treatment, only patients with sufficient intake gained body weight (2.3 ± 2.3 kg) and lean mass (1.2 ± 1.3 kg).Conclusion.Patients with head and neck cancer fail to maintain or improve nutritional status during treatment, despite sufficient intake. © 2010 Wiley Periodicals, Inc. Head Neck, 2011
Prevalence and impact on clinicopathological characteristics of human papillomavirus‐16 DNA in cervical lymph node metastases of head and neck squamous cell carcinoma
Authors: Weiss Daniel , Koopmann Mario , Rudack Claudia 
Published: August 2010

AbstractBackground.Human papillomavirus (HPV) is a basic risk factor for head and neck squamous cell carcinoma (HNSCC). Little knowledge exists about the impact of HPV on clinical diagnostic and therapy of patients with HNSCC.Methods.We evaluated the evidence of HPV16 in 131 retrospectively collected HNSCC and associated cervical lymph node metastases by HPV16 real‐time polymerase chain reaction (PCR) and p16 immunohistochemistry and its impact on clinicopathological characteristics.Results.HPV16‐DNA and p16 overexpression were present in 27% of HNSCCs. All cervical lymph node metastases of HPV16‐positive HNSCC showed HPV16‐DNA. HPV16 was strongly associated with tumors arising from the oropharyngeal site (p < .000001), favorable outcome after standard therapy in univariate (p = .001) and multivariate (p = .0004) analysis, and cervical lymph node metastases before primary detection.Conclusion.HPV16‐diagnostic in cervical lymph node metastases can predict the site of tumor origin in case of carcinoma of unknown primary (CUP) and favorable outcome and should, therefore, be included in routine diagnostic workup. © 2010 Wiley Periodicals, Inc. Head Neck, 2011
Survival analysis of head and neck squamous cell carcinoma: Influence of smoking and drinking
Authors: Farshadpour Farzaneh , Kranenborg Hanneke , Calkoen Eveline Van Beeck , Hordijk Gerrit Jan , Koole Ron , Slootweg Piet J. , Terhaard Chris H. 
Published: August 2010

AbstractBackground.Head and neck squamous cell carcinomas (HNSCCs) are associated with tobacco and alcohol; however, the prognostic relevance of these substances is unclear.Methods.Univariate and multivariate survival analyses were performed for patients with (n = 1829) and without (n = 183) substance use.Results.HNSCC‐specific survival (death due to primary‐HNSCC or recurrent HNSCC) and HNSCC/second primary tumor–specific survival (death due to primary‐HNSCC or recurrent HNSCC or second primary tumor) were not significantly different for patients who smoked and drank alcohol (hazard ratio [HR], 1.26; 95% confidence interval [CI], 0.86–1.85) and those who did not (HR, 1.34; 95% CI, 0.96–1.88). Overall survival was significantly affected; HR for patients who smoked and drank alcohol was 1.50 (95% CI, 1.16–1.93).Conclusion.Although tobacco and alcohol use are the main risk factors for development of HNSCC, disease outcome was comparable in patients who did or did not use these substances. Tobacco and alcohol use affected overall survival, which emphasizes the importance of substance use cessation. © 2010 Wiley Periodicals, Inc. Head Neck, 2011
Differences in history of sexual behavior between patients with oropharyngeal squamous cell carcinoma and patients with squamous cell carcinoma at other head and neck sites
Authors: Dahlstrom Kristina R. , Li Guojun , Tortolero‐Luna Guillermo , Wei Qingyi , Sturgis Erich M. 
Published: August 2010

AbstractBackground.An emerging epidemic of human papillomavirus (HPV)‐associated oropharyngeal cancer has been proposed. The purpose of this study was for us to compare the sexual behaviors of patients with squamous cell carcinoma of the oropharynx (SCCOP) and patients with squamous cell carcinoma of non‐oropharyngeal (SCCNOP) head and neck sites to expand our understanding of sexual behavior as a risk factor for HPV‐associated head and neck cancer.Methods.The sexual history of 165 patients with SCCOP and 87 patients with SCCNOP was determined in a hospital‐based case‐to‐case comparison study.Results.Patients with SCCOP were significantly more likely than patients with SCCNOP to have had >9 lifetime sex partners (odds ratio [OR], 39.2; 95% confidence interval [CI], 8.2–187.3), to have engaged in oral‐genital sex (OR, 3.5; 95% CI, 1.1–11.1), and to have had >4 oral‐genital sex partners (OR, 8.6; 95% CI, 2.2–33.4).Conclusion.The findings of this study suggest that some risk factors are site‐specific and provide further evidence that certain sexual behaviors increase the risk of HPV‐associated SCCOP. © 2010 Wiley Periodicals, Inc. Head Neck, 2011
Sclerotherapy of lymphangiomas of the head and neck
Authors: Wiegand Susanne , Eivazi Behfar , Zimmermann Annette P. , Sesterhenn Andreas M. , Werner Jochen A. 
Published: August 2010

AbstractLymphangiomas are congenital malformations of the lymphatic system that consist of cysts of varying size. Although they are benign, they can undergo progressive growth with compression and infiltration of adjacent structures. Surgical excision has been the cornerstone of treatment, although total excision of the lymphangioma can be a major challenge and may be associated with severe complications. Therefore, a variety of nonsurgical methods have been proposed to reduce the surgical morbidity and to decrease the recurrence rate. Percutaneous sclerotherapy of lymphangioma involves the injection of sclerosing substances into the lymphangioma cysts. During the past years, different sclerosants and sclerosant techniques have been developed. This review summarizes the current knowledge on sclerotherapy of lymphangiomas of the head and neck. © 2010 Wiley Periodicals, Inc. Head Neck, 2011
Polyethylenimine‐mediated PUMA gene delivery to orthotopic oral cancer: Suppression of tumor growth through apoptosis induction in situ and prolonged survival
Authors: Yeh Cheng‐Chang , Hsieh Hsiao‐Ling , Lee Jihjong , Jan Yi‐Hua , Lai Tsung‐Ching , Hong Chi‐Yuan , Hsiao Michael , Kuo Mark Y. P. 
Published: August 2010

AbstractBackground.PUMA (a p53 up‐regulated modulator of apoptosis) is induced by p53 tumor suppressor and other apoptotic stimuli. It was found to be a principal mediator of cell death in response to diverse apoptotic signals, implicating PUMA as a likely tumor suppressor.Methods.In this study, we examined the efficacy of targeted PUMA gene therapy in human oral cancer (SAS) cells using polyethylenimine (PEI)‐mediated transfection for gene delivery.Results.Exogenous expression of PUMA in SAS cells resulted in apoptosis with cytochrome c release, activation of caspase‐3 and ‐9, and cleavage of PARP. Gene delivery of PEI/PUMA in SAS xenografts induced apoptosis and resulted in significant reductions (∼60%) of tumor growth in vivo. Furthermore, we have shown that PEI‐mediated PUMA gene therapy prolonged survival of animals with orthotopic SAS oral cancers.Conclusions.Taken together, these results indicated that PUMA gene therapy via PEI delivery could be a promising method for the treatment of oral squamous cell carcinoma. © 2010 Wiley Periodicals, Inc. Head Neck, 2011
Evaluation of drug transporters' significance for multidrug resistance in head and neck squamous cell carcinoma
Authors: Theile Dirk , Ketabi‐Kiyanvash Nahal , Herold‐Mende Christel , Dyckhoff Gerhardt , Efferth Thomas , Bertholet Vincent , Haefeli Walter Emil , Weiss Johanna 
Published: August 2010

AbstractBackground.Multidrug resistance (MDR) hampers chemotherapy in head and neck squamous cell carcinoma (HNSCC). There is little information about MDR mediating drug transporters in HNSCC.Methods.Nine HNSCC cell lines were characterized concerning drug transporter expression and susceptibility to cisplatin, paclitaxel, and 5‐fluorouracil (5‐FU) using a DNA microarray and proliferation assays. Three cells lines were precisely investigated for transporter expression using reverse transcriptase‐polymerase chain reaction (RT‐PCR) and drug resistance before and after simulated chemotherapies.Results.The cell lines differed in drug resistance and transporter expression. Cisplatin and paclitaxel resistances were inversely associated. Drugs rendered HNSCC cells resistant, cross‐resistant, or cross‐sensitive. Sensitivity changes were accompanied by transporter mRNA expression changes.Conclusion.Paclitaxel was identified as a potent inducer of numerous drug transporters and phenotypic MDR in HNSCC. Thus, cytostatic susceptibility of HNSCC cannot exclusively be deduced from the expression of single transporters but more likely of the entire transportome and non‐transporter modulators. © 2010 Wiley Periodicals, Inc. Head Neck, 2011
Evaluation of floodplain variability considering impacts of climate change
Authors: Karamouz Mohammad , Noori Navideh , Moridi Ali , Ahmadi Azadeh 
Published: August 2010

AbstractIn this study, an approach is presented for handling hydraulic uncertainties in the prediction of floodplain. Different factors affect river flood characteristics. Furthermore, the high changeability of flooding conditions leads to high variability of the inundation.River morphology is one of the most effective factors in river flood characteristics. This factor is influenced by sedimentation and erosion in the river cross sections, which affects the discharge variation. The depth and the width of the river cross section lead to an increase or decrease in the river flow path. This results in changes in the extent of the floodplain based on the generated rainfall. The inundated region boundaries are determined by utilizing the mean first‐order second‐moment analysis. The proposed method is applied to the Kajoo River in the south‐eastern part of Iran. Determination of floodplain uncertainty is a damage‐reduction policy in this region. Also, it is useful to prepare the necessary activities for overcoming the flood hazards.Climate change is the second effective factor on the floodplain uncertainties. Climate change affects the magnitude, extent and depth of inundation and it may intensify the flood problem. Therefore, the future rainfall pattern of the study area under climate change is simulated to evaluate its impacts on the river flow characteristic. Subsequently, a hydraulic routing model is used to determine floodplain. Finally, the copula function is used to estimate the joint probability of the changes in the inundation area due to changes in river morphology and the rainfall changes due to impacts of climate change.Results show that the uncertainties of the extent of floodplain are affected by climate change and river morphology, leading to noticeable changes in the magnitude and frequency of floods. Evaluating these impacts and estimating corresponding river discharges will help in the study of river dynamics, and will also contribute towards devising effective mitigation and management strategies. Copyright © 2010 John Wiley & Sons, Ltd.
Comparative study of neural network, fuzzy logic and linear transfer function techniques in daily rainfall‐runoff modelling under different input domains
Authors: Lohani Anil Kumar , Goel N. K. , Bhatia K. K. S. 
Published: August 2010

AbstractThis paper compares artificial neural network (ANN), fuzzy logic (FL) and linear transfer function (LTF)‐based approaches for daily rainfall‐runoff modelling. This study also investigates the potential of Takagi‐Sugeno (TS) fuzzy model and the impact of antecedent soil moisture conditions in the performance of the daily rainfall‐runoff models. Eleven different input vectors under four classes, i.e. (i) rainfall, (ii) rainfall and antecedent moisture content, (iii) rainfall and runoff and (iv) rainfall, runoff and antecedent moisture content are considered for examining the effects of input data vector on rainfall‐runoff modelling. Using the rainfall‐runoff data of the upper Narmada basin, Central India, a suitable modelling technique with appropriate model input structure is suggested on the basis of various model performance indices. The results show that the fuzzy modelling approach is uniformly outperforming the LTF and also always superior to the ANN‐based models. Copyright © 2010 John Wiley & Sons, Ltd.
Transfer function‐noise modelling of an aquifer system in NE Italy
Authors: Fabbri Paolo , Gaetan Carlo , Zangheri Pietro 
Published: August 2010

AbstractIn this article, we use a transfer function‐noise (TFN) modelling strategy with single output and multiple/single inputs to study the relationships among a large unconfined aquifer in the upper Venetian plain (Northeast Italy), its recharge components (rainfalls and losing river) and a multi‐layered confined system located in the middle Venetian plain. Model identification from the data raises a range of difficulties when seeking models with consistent physical behaviour, but no information related to the transfer function order and the lags with no zero weights is available. Therefore we use an automatic identification procedure for TFN models. The obtained results suggest that the rainfall component is more important than the river discharge in the unconfined aquifer, and the behaviours of the deep‐confined aquifers are synchronous with that observed in the Badoere area. Copyright © 2010 John Wiley & Sons, Ltd.
The parenting dimensions of British Pakistani and White mothers of primary school children
Authors: Ali Shama , Frederickson Norah 
Published: August 2010

AbstractThere is increasing emphasis internationally on the use of parenting programmes to support the development of appropriate social behaviour in children. However, in such programmes diversity is often ignored. Research into the parenting styles and practices (dimensions) of different ethnic groups is needed in order to investigate the applicability of universal programmes, to guide their design and implementation in the future. Thirty‐four British Pakistani and 34 British White mothers of primary aged children, comprising equal numbers of males and females, completed English or Urdu versions of the Parental Dimensions Inventory—Short Version (PDI‐S), (Power, Int. J. Behav. Dev. 67: 302–313) and a child behavioural screening instrument, the SDQ (Goodman, J. Child Psychol. Psychiatry 38: 581–586).More similarities than differences between the parenting dimensions of Pakistani and White mothers were found overall. However, compared with White mothers, Pakistani mothers reported more ‘following through on discipline’ as well as ‘reminding’ as a disciplinary action. Further, Pakistani mothers reported following through on discipline more with boys than White mothers did and the more they reported inconsistent parenting, the more their children reportedly had behaviour problems. It is concluded that while these findings provide some support for the cross‐cultural applicability of generic parenting programmes, programme efficacy studies are also needed. Copyright © 2010 John Wiley & Sons, Ltd.
Erratum: Probabilistic application of a fugacity model to predict triclosan fate during wastewater treatment
Authors: Bock Michael , Lyndall Jennifer , Barber Timothy , Fuchsman Phyllis , Perruchon Elyse , Capdevielle Marie 
Published: August 2010

Abstract
The fate and partitioning of the antimicrobial compound, triclosan, in wastewater treatment plants (WWTPs) is evaluated using a probabilistic fugacity model to predict the range of triclosan concentrations in effluent and secondary biosolids. The WWTP model predicts 84% to 92% triclosan removal, which is within the range of measured removal efficiencies (typically 70% to 98%). Triclosan is predominantly removed by sorption and subsequent settling of organic particulates during primary treatment and by aerobic biodegradation during secondary treatment. Median modeled removal efficiency due to sorption is 40% for all treatment phases and 31% in the primary treatment phase. Median modeled removal efficiency due to biodegradation is 48% for all treatment phases and 44% in the secondary treatment phase. Important factors contributing to variation in predicted triclosan concentrations in effluent and biosolids include influent concentrations, solids concentrations in settling tanks, and factors related to solids retention time. Measured triclosan concentrations in biosolids and non-United States (US) effluent are consistent with model predictions. However, median concentrations in US effluent are over-predicted with this model, suggesting that differences in some aspect of treatment practices not incorporated in the model (e.g., disinfection methods) may affect triclosan removal from effluent. Model applications include predicting changes in environmental loadings associated with new triclosan applications and supporting risk analyses for biosolids-amended land and effluent receiving waters. Integr Environ Assess Manag 2010;6:393–404. © 2010 SETAC
Oncolytic designer host defense peptide suppresses growth of human liposarcoma
Authors: Steinstraesser Lars , Schubert Cornelius , Hauk Jennifer , Becerikli Mustafa , Stricker Ingo , Koeller Manfred , Hatt Hanns , von Duering Monika , Shai Yechiel , Steinau Hans‐Ulrich , Jacobsen Frank 
Published: August 2010

AbstractSarcomas display a rare and heterogeneous group of tumors. Treatment options are limited. Host defense peptides (HDPs), effector molecules of the innate immune system, might provide a more effective treatment option. The aim of our study was to analyze the oncolytic activity and mode of action of a designer HDP. In vitro, the human liposarcoma cell line SW‐872 and primary human fibroblasts as a control were exposed to [D]‐K3H3L9, a 15‐mer D,L‐amino acid designer peptide. Cell growth (MTT assay), proliferation (BrdU assay) and genotoxicity (TUNEL assay) were analyzed. The mode of action was examined via fluorescence‐activated cell sorter (FACS) analysis and confocal laser scanning microscopy. In vivo, [D]‐K3H3L9 (n = 7) was administered intratumorally in a SW‐872 xenograft mouse model (Foxn1nu/nu). Phosphate buffered saline served as a control (n = 5). After 4 weeks, tumor sections were histologically analyzed with respect to proliferation, cytotoxicity, vessel density and signs of apoptosis and necrosis, respectively. In vitro, [D]‐K3H3L9 highly significantly (p < 0.01) inhibited cell metabolism and proliferation. TUNEL assay revealed corresponding genotoxicity. FACS analysis suggested induction of necrosis as a cause of cell death. The mean tumor volume of the control group exponentially increased sevenfold, whereas the mean tumor growth was negligible in the treatment group. Macroscopically, [D]‐K3H3L9 induced full tumor remission in 43% of treated animals and partial remission in 43%. Vessel density was significantly reduced by 52%. Morphological analyses supported the hypothesis of cancer cell killing by necrosis. In summary, [D]‐K3H3L9 exerts very promising oncolytic activity on liposarcoma cells. Our study demonstrates the potential of HDPs as a novel therapeutic option in future soft tissue sarcoma therapy.