bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dietary and genetic determinants of non-alcoholic fatty liver disease in coronary heart disease patients
Authors: Heerkens Luc , Geleijnse Johanna M. , van Duijnhoven Fränzel J. B. 
Published: June 2024

Abstract
Purpose
A healthy diet reduces the risk of non-alcoholic fatty liver disease (NAFLD) in the general population, especially in individuals who are genetically predisposed to NAFLD. Little is known in patients who suffered from a myocardial infarction (MI). We examined the interaction between diet quality and genetic predisposition in relation to NAFLD in post-MI patients.

Methods
We included 3437 post-MI patients from the Alpha Omega Cohort. Diet quality was assessed with adherence to the Dutch Healthy Diet index 2015 (DHD15-index). A weighted genetic risk score (GRS) for NAFLD was computed using 39 genetic variants. NAFLD prevalence was predicted using the Fatty Liver Index. Prevalence ratios (PR) with 95% confidence intervals of DHD15-index and GRS in relation to NAFLD were obtained with multivariable Cox proportional hazards models. The interaction between DHD15-index and GRS in relation to NAFLD was assessed on an additive and multiplicative scale.

Results
Patients had a mean age of 69 (± 5.5) years, 77% was male and 20% had diabetes. The DHD15-index ranged from 28 to 120 with a mean of 73. Patients with higher diet quality were less likely to suffer from NAFLD, with a PR of 0.76 (0.62, 0.92) for the upper vs lower quintile of DHD15-index. No association between the GRS and NAFLD prevalence was found (PR of 0.92 [0.76, 1.11]). No statistically significant interaction between the DHD15-index and GRS was observed.

Conclusion
In Dutch post-MI patients, adherence to the Dutch dietary guidelines was associated with a lower prevalence of NAFLD, as assessed by the FLI. This association was present regardless of genetic predisposition in this older aged cohort.
Low magnesium in conjunction with high homocysteine increases DNA damage in healthy middle aged Australians
Authors: Dhillon Varinderpal S. , Deo Permal , Fenech Michael 
Published: June 2024

Abstract
Purpose
Magnesium is one of the most common elements in the human body and plays an important role as a cofactor of enzymes required for DNA replication and repair and many other biochemical mechanisms including sensing and regulating one-carbon metabolism deficiencies. Low intake of magnesium can increase the risk of many diseases, in particular, chronic degenerative disorders. However, its role in prevention of DNA damage has not been studied fully in humans so far. Therefore, we tested the hypothesis that magnesium deficiency either on its own or in conjunction with high homocysteine (Hcy) induces DNA damage in vivo in humans.

Methods
The present study was carried out in 172 healthy middle aged subjects from South Australia. Blood levels of magnesium, Hcy, folate and vitamin B12 were measured. Cytokinesis-Block Micronucleus cytome assay was performed to measure three DNA damage biomarkers: micronuclei (MN), nucleoplasmic bridges (NPBs) and nuclear buds (NBuds) in peripheral blood lymphocytes.

Results
Data showed that magnesium and Hcy are significantly inversely correlated with each other (r = − 0.299, p < 0.0001). Furthermore, magnesium is positively correlated both with folate (p = 0.002) and vitamin B12 (p = 0.007). Magnesium is also significantly inversely correlated with MN (p < 0.0001) and NPB (p < 0.0001). Individuals with low magnesium and high Hcy exhibited significantly higher frequency of MN and NPBs compared to those with high magnesium and low Hcy (p < 0.0001). Furthermore, there was an interactive effect between these two factors as well in inducing MN (p = 0.01) and NPB (p = 0.048).

Conclusions
The results obtained in the present study indicate for the first time that low in vivo levels of magnesium either on its own or in the presence of high Hcy increases DNA damage as evident by higher frequencies of MN and NPBs.
Malonate given at reperfusion prevents post-myocardial infarction heart failure by decreasing ischemia/reperfusion injury
Authors: Abe Jiro , Vujic Ana , Prag Hiran A. , Murphy Michael P. , Krieg Thomas 
Published: June 2024

AbstractThe mitochondrial metabolite succinate is a key driver of ischemia/reperfusion injury (IRI). Targeting succinate metabolism by inhibiting succinate dehydrogenase (SDH) upon reperfusion using malonate is an effective therapeutic strategy to achieve cardioprotection in the short term (< 24 h reperfusion) in mouse and pig in vivo myocardial infarction (MI) models. We aimed to assess whether inhibiting IRI with malonate given upon reperfusion could prevent post-MI heart failure (HF) assessed after 28 days. Male C57BL/6 J mice were subjected to 30 min left anterior coronary artery (LAD) occlusion, before reperfusion for 28 days. Malonate or without-malonate control was infused as a single dose upon reperfusion. Cardiac function was assessed by echocardiography and fibrosis by Masson’s trichrome staining. Reperfusion without malonate significantly reduced ejection fraction (~ 47%), fractional shortening (~ 23%) and elevated collagen deposition 28 days post-MI. Malonate, administered as a single infusion (16 mg/kg/min for 10 min) upon reperfusion, gave a significant cardioprotective effect, with ejection fraction (~ 60%) and fractional shortening (~ 30%) preserved and less collagen deposition. Using an acidified malonate formulation, to enhance its uptake into cardiomyocytes via the monocarboxylate transporter 1, both 1.6 and 16 mg/kg/min 10 min infusion led to robust long-term cardioprotection with preserved ejection fraction (> 60%) and fractional shortening (~ 30%), as well as significantly less collagen deposition than control hearts. Malonate administration upon reperfusion prevents post-MI HF. Acidification of malonate enables lower doses of malonate to also achieve long-term cardioprotection post-MI. Therefore, the administration of acidified malonate upon reperfusion is a promising therapeutic strategy to prevent IRI and post-MI HF.
Nonmetric sex estimation in a contemporary Indonesian population: a validation study using clinical pelvic MSCT scans
Authors: Lye Ridhwan , Obertová Zuzana , Bachtiar Nur Amelia , Franklin Daniel 
Published: June 2024

AbstractKlales et al. (2012) is a popular standard for the estimation of skeletal sex. Since its publication, a number of studies have demonstrated that population-specific applications of Klales improve classification accuracy. However, it has also been shown that age appears to affect the expression of dimorphism in the pelvis across the lifespan. As such, the present study examines the accuracy of Klales, and the modified global standard of Kenyhercz et al. (2017), in a contemporary Indonesian population, including quantifying the effect of age. Pelvic multi-slice CT scans of 378 individuals (213 female; 165 male) were analysed in OsiriX®. Both standards were tested and Indonesian-specific models thereafter derived.When applied to the Indonesian sample, both the Klales and Kenyhercz standards resulted in lower classification accuracy relative to the original studies. In considering the Indonesian-specific models, the ventral arc was the most accurate for the classification of sex, at 93.3% with a − 3.0% sex bias. The accuracy of the three-trait model was 94.4%, with a − 5.5% sex bias. Age was shown to significantly affect the distribution of pelvic trait scores. As such, age-dependent models were also derived, with the standard for individuals between 30 and 49 years the most accurate, at 93.1% and a sex bias of − 4.0%. Accuracy was lower in individuals aged ≥ 50 years, at 91.3% and a sex bias of 4.1%. These findings support the importance of establishing population-specific standards and to facilitate improved accuracy and capabilities for forensic practitioners in Indonesia.
Development and psychometric evaluation of the type 1 diabetes mellitus self-management scale for parents
Authors: Ceran Merve Aşkın , Bektaş Murat , Eklioğlu Beray Selver 
Published: June 2024

Abstract
Background/aim
Diabetes has become a global epidemic, necessitating effective self-management strategies. This is particularly crucial for parents of children with type 1 diabetes mellitus, as they must make numerous daily decisions and perform complex care activities. Therefore, the aim of this study was to develop a comprehensive diabetes self-management scale specifically for parents of children with type 1 diabetes. This scale aims to holistically address behaviors impacting diabetes self-management and to evaluate its psychometric properties.

Materials and methods
A methodological, correlational, and cross-sectional study was conducted with a sample of 190 parents of children with type 1 diabetes mellitus. The scale items were reviewed by five experts to ensure they adequately covered the parents' evaluation of their children's diabetes self-management. Following this, a Turkish language expert assessed the draft scale for language accuracy, comprehensibility, and grammar. The data were analyzed using descriptive statistics (numbers and percentages), Cronbach's α reliability coefficient, factor analysis, and correlation analysis.

Results
The Cronbach's alpha for the overall scale was 0.893, and the Cronbach's alpha for the subscales was between 0.757 and 0.845. The item-total score correlations ranged between 0.408 and 0.660 (p < .05). The exploratory factor analysis showed that the scale explained 61.427% of the total variance, and the factor loadings of items ranged from 0.574 to 0.859. The confirmatory factor analysis also showed that the factor loadings of the scale items ranged from 0.574 to 0.859.
Conclusion: The validity and reliability analyses revealed that the scale is a valid and reliable measurement tool for the Turkish culture.
Approximate and Randomized Algorithms for Computing a Second Hamiltonian Cycle
Authors: Deligkas Argyrios , Mertzios George B. , Spirakis Paul G. , Zamaraev Viktor 
Published: June 2024

AbstractIn this paper we consider the following problem: Given a Hamiltonian graph G, and a Hamiltonian cycle C of G, can we compute a second Hamiltonian cycle $$C^{\prime } \ne C$$

C
′

≠
C

of G, and if yes, how quickly? If the input graph G satisfies certain conditions (e.g. if every vertex of G is odd, or if the minimum degree is large enough), it is known that such a second Hamiltonian cycle always exists. Despite substantial efforts, no subexponential-time algorithm is known for this problem. In this paper we relax the problem of computing a second Hamiltonian cycle in two ways. First, we consider approximating the length of a second longest cycle on n-vertex graphs with minimum degree $$\delta $$
δ
and maximum degree $$\Delta $$
Δ
. We provide a linear-time algorithm for computing a cycle $$C^{\prime } \ne C$$

C
′

≠
C

of length at least $$n-4\alpha (\sqrt{n}+2\alpha )+8$$

n
-
4
α
(

n

+
2
α
)
+
8

, where $$\alpha = \frac{\Delta -2}{\delta -2}$$

α
=

Δ
-
2

δ
-
2

. This results provides a constructive proof of a recent result by Girão, Kittipassorn, and Narayanan in the regime of $$\frac{\Delta }{\delta } = o(\sqrt{n})$$

Δ
δ

=
o

(

n

)

. Our second relaxation of the problem is probabilistic. We propose a randomized algorithm which computes a second Hamiltonian cycle with high probability, given that the input graph G has a large enough minimum degree. More specifically, we prove that for every $$0<p\le 0.02$$

0
<
p
≤
0.02

, if the minimum degree of G is at least $$\frac{8}{p} \log \sqrt{8}n + 4$$

8
p

log

8

n
+
4

, then a second Hamiltonian cycle can be computed with probability at least $$1 - \frac{1}{n}\left( \frac{50}{p^4} + 1 \right) $$

1
-

1
n

50

p
4

+
1

in $$poly(n) \cdot 2^{4pn}$$

p
o
l
y

(
n
)

·

2

4
p
n

time. This result implies that, when the minimum degree $$\delta $$
δ
is sufficiently large, we can compute with high probability a second Hamiltonian cycle faster than any known deterministic algorithm. In particular, when $$\delta = \omega (\log n)$$

δ
=
ω
(
log
n
)

, our probabilistic algorithm works in $$2^{o(n)}$$

2

o
(
n
)

time.
Ambulatory blood pressure parameters and their association with albuminuria in adolescents with type 1 diabetes mellitus
Authors: Sołtysiak Jolanta , Skowrońska Bogda , Maćkowiak-Lewandowicz Katarzyna , Blumczyński Andrzej , Elżbieta Kaczmarek , Ostalska-Nowicka Danuta , Zachwieja Jacek 
Published: June 2024

Abstract
Background
This study aimed to evaluate the blood pressure (BP) status, including arterial stiffness parameters, hemodynamic indicators, circadian profile, and its association with albuminuria in adolescents with type 1 diabetes mellitus (DM1).

Methods
The analysis included 46 patients, with diabetes duration of 7.38 ± 3.48 years. Ambulatory blood pressure monitoring (ABPM) was conducted using an oscillometric device, the Mobil-O-Graph, which is a Pulse Wave Analysis Monitor.

Results
Hypertension (HT) was diagnosed in 31 adolescents (67% of patients), primarily due to isolated nocturnal BP (21 cases, 68% of HT cases). The HT group exhibited significantly increased diastolic load (DL). Pulse wave velocity (PWV, a measure of arterial stiffness) values showed a strong correlation with both peripheral systolic BP (r = 0.954) and central systolic BP (r = 0.838). Additionally, non-dipping status was found in 61% of the HT group. Urinary albumin excretion (UAE) was positively correlated with diastolic BP (particularly nocturnal) peripheral and central BP, DL, heart rate, augmentation index (AIx@75), and nocturnal total vascular resistance (TVR). Diastolic non-dippers exhibited a significant increase in UAE.

Conclusions
Hypertension is a common complication in adolescents with type 1 diabetes mellitus, primarily caused by elevated nocturnal diastolic BP. Albuminuria is mainly associated with diastolic BP, especially during the nocturnal period and in cases of diastolic non-dipping status. The association of UAE with AIx@75 and nocturnal TVR suggests the presence of early-stage vascular disease in diabetic adolescents.

Graphical abstract
Health-related quality of life in rural cancer survivors compared with their urban counterparts: a systematic review
Authors: Latham S. , Leach M. J. , White V. M. , Webber K. , Jefford M. , Lisy K. , Davis N. , Millar J. L. , Evans S. , Emery J. D. , IJzerman M. , Ristevski E. 
Published: June 2024

Abstract
Purpose
We conducted a systematic review to describe health-related quality of life (HRQOL) in rural cancer survivors (RCS), and compare HRQOL between RCS and urban cancer survivors (UCS).

Method
We searched Medline, Embase, CINAHL Plus, and PsycINFO for studies with HRQOL in adult cancer survivors living in rural, regional, remote, and urban areas, who had completed definitive primary cancer treatment, without evidence of residual disease. Where available, we used normative and clinically important values to ascribe meaning to HRQOL data.

Findings
Fifteen studies (16 papers) were included. Most were from the US (n = 8) and reported on breast cancer survivors (n = 9). Six HRQOL instruments, collecting data across 16 domains, were used. Three instruments were specific to the survivorship phase. Normative and clinical data were available for 12 studies. Compared with normative populations, RCS had clinically worse physical HRQOL (6/12 studies), better social/family (5/7), and functional (3/6) HRQOL, and there were no differences in emotional or/mental HRQOL (9/12). In six studies with rural–urban comparator groups and normative and clinically important data, RCS and UCS had clinically worse physical (3/6 and 2/6, respectively) and better social/family (3/4 and 2/4 studies, respectively) HRQOL than normative populations. Functional HRQOL was better in RCS (2/4 studies) than UCS and normative populations. In 3/6 studies, there were no clinical differences in emotional or/mental HRQOL between RCS, UCS, and normative populations.

Conclusion
Overall, HRQOL is not clearly better or worse in RCS than UCS. Future research should include different tumor types, rural residents, and survivorship-specific HRQOL instruments.
Clinical features of audible upper airway secretions (“death rattle”) in patients with cancer in the last days of life
Authors: Davies Andrew , Waghorn Melanie , Skene Simon 
Published: June 2024

Abstract
Purpose
Audible upper airway secretions (“death rattle”) is a common problem in cancer patients at the end-of-life. However, there is little information about its clinical features.

Methods
This is a secondary analysis of a cluster randomised trial of clinically-assisted hydration in cancer patients in the last days of life. Patients were assessed 4 hourly for end-of-life problems (including audible secretions), which were recorded as present or absent, excepting restlessness/agitation, which was scored using the modified Richmond Agitation and Sedation Scale. Patients were followed up until death.

Results
200 patients were recruited, and 186 patients died during the study period. Overall, 54.5% patients developed audible secretions at some point during the study, but only 34.5% patients had audible secretions at the time of death. The prevalence of audible secretions increased the closer to death, with a marked increase in the last 12–16 h of life (i.e. the prevalence of audible secretions was highest at the time of death). Of those with audible secretions at the time of death, 24 had had a previous episode that had resolved. Development of audible secretions was not associated with use of clinically-assisted hydration, but there was an association between audible secretions and restlessness/agitation, and audible secretions and pain. However, most patients with audible secretions were not restless/agitated, or in pain, when assessed.

Conclusion
Audible secretions (“death rattle”) are common in cancer patients at the end-of-life, but their natural history is extremely variable, with some patients experiencing multiple episodes during the terminal phase (although not necessarily experiencing an episode at the time of death).
Gene selection based on recursive spider wasp optimizer guided by marine predators algorithm
Authors: Osama Sarah , Ali Abdelmgeid A. , Shaban Hassan 
Published: June 2024

AbstractDetecting tumors using gene analysis in microarray data is a critical area of research in artificial intelligence and bioinformatics. However, due to the large number of genes compared to observations, feature selection is a central process in microarray analysis. While various gene selection methods have been developed to select the most relevant genes, these methods’ efficiency and reliability can be improved. This paper proposes a new two-phase gene selection method that combines the ReliefF filter method with a novel version of the spider wasp optimizer (SWO) called RSWO-MPA. In the first phase, the ReliefF filter method is utilized to reduce the number of genes to a reasonable number. In the second phase, RSWO-MPA applies a recursive spider wasp optimizer guided by the marine predators algorithm (MPA) to select the most informative genes from the previously selected ones. The MPA is used in the initialization step of recursive SWO to narrow down the search space to the most relevant and accurate genes. The proposed RSWO-MPA has been implemented and validated through extensive experimentation using eight microarray gene expression datasets. The enhanced RSWO-MPA is compared with seven widely used and recently developed meta-heuristic algorithms, including Kepler optimization algorithm (KOA), marine predators algorithm (MPA), social ski-driver optimization (SSD), whale optimization algorithm (WOA), Harris hawks optimization (HHO), artificial bee colony (ABC) algorithm, and original SWO. The experimental results demonstrate that the developed method yields the highest accuracy, selects fewer features, and exhibits more stability than other compared algorithms and cutting-edge methods for all the datasets used. Specifically, it achieved an accuracy of 100.00%, 94.51%, 98.13%, 95.63%, 100.00%, 100.00%, 92.97%, and 100.00% for Yeoh, West, Chiaretti, Burcyznski, leukemia, ovarian cancer, central nervous system, and SRBCT datasets, respectively.
Dynamic and thermodynamic characteristics of warm-sector rainstorms caused by the southwest china vortex in sichuan basin
Authors: Zhou Chunhua , Li Yueqing 
Published: June 2024

AbstractUsing automatic rainfall station and ERA5 reanalysis data, the Southwest China vortex (SWCV) processes that induce warm-sector rainstorms in the Sichuan Basin were analyzed, their environmental field and dynamic thermal characteristics were researched through physical diagnosis and dynamic synthesis, and the development mechanism was discussed. The results showed that for the warm-sector rainstorms caused by the SWCV (SWCV-WR), the general circulation backgrounds can could be divided into three types: upper trough-vortex (Type I), plateau shear line (Type II), and short-wave trough (Type III) types. Regarding the aspects of the maintenance of the SWCV, duration of the warm-sector rainstorms, and maximum hourly precipitation intensity, the influence of Type I is the most evident, followed by Types II and III for SWCV-WR. The vertical structure of the SWCV is shallow and inclined to the west with height, but the positive vorticity of Types I and II can reach up to 200 hPa for SWCV-WR. The pseudo-equivalent potential temperature in the vortex area is greater than 354 K, which is accompanied by an upward-energy tongue, and shallow secondary circulation occurs on the eastern side of the SWCV, promoting vortex development. Regarding the thermodynamic characteristics of SWCV, Type I is the strongest, followed by Type III, and Type II is the weakest. The water vapor supply in different types of SWCV-WR is not only closely related to the strength of water vapor transport in the Bay of Bengal, but also to the variations in water vapor transport caused by the influence of different water vapor sources, such as the South China Sea and western Pacific Ocean, during its transportation. For SWCV-WR, the vorticity advection presents an uneven east-west positive and negative distribution. Under the dynamic forcing, the positive vorticity on the east side of SWCV of Types I and II (III) is enhanced (weakened), while that on the west side is weakened (enhanced). Different atmospheric vorticity variations have different significant effects on the three types of SWCV-WR. Under the spatial non-uniform heating, the horizontal non-uniform heating effect on the different types of SWCV-WR has regional differences, while the vertical non-uniform heating effect has the largest effect on the spatial non-uniform heating and a positive heating effect on the three types of SWCV-WR. Therefore, the spatial non-adiabatic heating effect, particularly the vertical non-uniform heating effect, is an important mechanism for the development and evolution of SWCV and SWCV-WR.