bluuebunny/crossref_metadata_2025_split huggingface dataset:
Festphasen‐Alkoholoxidation mittels Direkter Mechanokatalyse
Authors: Wohlgemuth Maximilian , Schmidt Sarah , Mayer Maike , Pickhardt Wilm , Graetz Sven , Borchardt Lars 
Published: May 2024

AbstractDiese Publikation stellt einen neuartigen Ansatz für die selektive Oxidation von Alkoholen zu den entsprechenden Aldehyden durch direkte Mechanokatalyse vor, wobei ein mit Gold beschichtetes Mahlgefäß als Katalysator und Luftsauerstoff als Oxidationsmittel verwendet werden. Durch die Anpassung der Mahlfrequenz, der Mahlmedien und der Mahlzeit werden hohe Katalysatoraktivität und Selektivitäten erreicht. Zudem werden für bestimmte Substrate Ausbeuten von bis zu 99 % erzielt, sowie eine Turnover Number (TON) von 8200 und eine Turnover Frequency (TOF) von 0,77 s−1, was bestehende Alternativen übertrifft. Mittels Röntgenphotoelektronenspektroskopie (XPS) konnte bestätigt werden, dass die katalytische Reaktion tatsächlich auf der Oberfläche des Mahlwerkzeugs stattfindet.
Nickel‐Catalyzed Highly Selective Radical C−C Coupling from Carboxylic Acids with Photoredox Catalysis
Authors: Ling Bo , Yao Shunruo , Ouyang Shengmao , Bai Haonan , Zhai Xinyi , Zhu Chengjian , Li Weipeng , Xie Jin 
Published: May 2024

AbstractControlling the cross‐coupling reaction between two different radicals is a long‐standing challenge due to the process occurring statistically, which would lead to three products, including two homocoupling products and one cross‐coupling product. Generally, the cross‐coupling selectivity is achieved by the persistent radical effect (PRE) that requires the presence of a persistent radical and a transient radical, thus resulting in limited radical precursors. In this paper, a highly selective cross‐coupling of alkyl radicals with acyl radicals to construct C(sp2)−C(sp3) bonds, or with alkyl radicals to construct C(sp3)−C(sp3) bonds have been achieved with the readily available carboxylic acids and their derivatives (NHPI ester) as coupling partners. The success originates from the use of tridentate ligand (2,2′ : 6′,2′′‐terpyridine) to enable radical cross‐coupling process to Ni‐mediated organometallic mechanism. This protocol offers a facile and flexible access to structurally diverse ketones (up to 90 % yield), and also a new solution for the challenging double decarboxylative C(sp3)−C(sp3) coupling. The broad utility and functional group tolerance are further illustrated by the late‐stage functionalization of natural‐occurring carboxylic acids and drugs.
Highly active and selective ZIF‐derived cobalt catalyst for methanol conversion to dimethyl carbonate
Authors: Wang Liping , Meng Fanhui , Ding Pengfei , Nawaz Muhammad Asif , Li Zhong 
Published: May 2024

The oxidative carbonylation of methanol to synthesize dimethyl carbonate (DMC) has been extensively studied over Cu‐based catalysts, but the activity and selectivity are not high. The Co catalysts exhibit high DMC selectivity, but the difficulty in recycling homogeneous Co catalyst and the low conversion of heterogeneous Co catalyst limit the application of Co catalysts. Here, the core–shell ZIFs materials were synthesized and carbonized to obtain solid core–shell cobalt catalysts, and then the catalytic performance for methanol conversion to DMC was investigated. The CoNC@NC catalyst, carbonized from Z67@Z8 with Z67 as the core and Z8 as the shell, shows that the carbonized NC shell effectively suppressed the aggregation of Co NPs and the Co NPs were only 15.4 nm, which was much smaller than those of NC@CoNC (34.5 nm) and CoNC (48.1 nm) catalysts. Compared with the CoNC catalyst, CoNC@NC significantly improved the pulse chemisorption of CH3OH and CO, leading to a significant increase in methanol conversion from 6.9% to 17.1%. Furthermore, the deactivation rate of the CoNC@NC catalyst (22.8%) was much lower than that of CoNC (59.4%) after five reaction cycles. The results of this work provide a new strategy for the design and preparation of solid cobalt catalysts for the oxidative carbonylation of methanol to DMC.
Limited spatiotemporal larval mixing of the Norway lobster from no‐take marine protected areas in the northwestern Mediterranean Sea
Authors: Clavel‐Henry Morane , Bahamon Nixon , Aguzzi Jacopo , Navarro Joan , López Miguel , Company Joan B. 
Published: May 2024

Abstract
The larvae of many marine species are pelagic drifters in the vast oceans, yet they are the first and, for sessile species, the only way to connect with other populations. Connectivity is of particular interest in designing and assessing marine protected areas (MPAs), as it is considered a factor of renewal and stability.
In this study, we focused on larval mixing between MPAs, investigating mixing rates during and at the end of their pelagic life, and how this is affected by the timing of larval release. We used a particle transport model coupled to the climatological hydrodynamics of the northwestern Mediterranean Sea to simulate the trajectories of Nephrops norvegicus larvae. Larvae were released from four no‐take MPAs, where fishery activity is banned, and started mixing between 7 and 12 days old.
At settlement time, larval mixing mainly occurred between two pairs of MPAs labelled AxB (49.4% ± 5.8%) and CxD (23.7% ± 10.7%), respectively, located on the northern and southern sides of a thermal front. Percentages of larval mixing between these pairs changed, and other MPA combinations were formed with delayed larval release times. Mixing of larvae released from the same MPA tended to decrease with increasing delays between release times.
This variability in mixing was related to the latitudinal distribution of MPAs along the continental slope and the spatiotemporal dynamics of the regional hydrodynamics, with a strong impact from a thermal front.
Larval mixing modelling is a useful measure for understanding connectivity in marine environments and can suggest new conservation decisions. It identifies MPAs that are spatially distributed to facilitate the convergence of larvae from various protected areas. It also underlines that recognizing the significance of hydrodynamic variability when designing MPAs is crucial for promoting efficient connectivity among these areas.
Insights Into Scalable Technologies and Process Chains for Sulfide‐Based Solid‐State Battery Production
Authors: Singer Célestine , Wach Lovis , Jaimez Farnham Elena , Daub Rüdiger 
Published: May 2024

AbstractThe successful utilization of innovative sulfide‐based solid‐state batteries in energy storage hinges on developing scalable technologies and machinery for upscaling their production. While multiple Gigafactories for lithium‐ion batteries are already operational worldwide, the upscaling of solid‐state batteries exhibiting their full potential remains to be seen in the near future. In this study, the conventional production of lithium‐ion batteries is reconsidered, and the feasibility of seamlessly integrating sulfide‐based solid‐state batteries into the existing process chains is discussed. Scalable technologies and key challenges along the process chain of sulfide‐based solid‐state batteries are accordingly addressed. Experimental investigations yield crucial insights into enabling large‐scale production of sulfide‐based battery components while highlighting remaining challenges from a production perspective. An overview of the roll‐to‐roll machinery housed in microenvironments under an inert atmosphere in the “Sulfidic Cell Production Advancement Center” at the Institute for Machine Tools and Industrial Management at the Technical University of Munich is given.
Basic leucine zipper transcription activators – tools to improve production and quality of human erythropoietin in Nicotiana benthamiana
Authors: Wagner Nazgul , Musiychuk Konstantin , Shoji Yoko , Tottey Stephen , Streatfield Stephen J. , Fischer Rainer , Yusibov Vidadi 
Published: May 2024

AbstractHuman erythropoietin (hEPO) is one of the most in‐demand biopharmaceuticals, however, its production is challenging. When produced in a plant expression system, hEPO results in extensive plant tissue damage and low expression. It is demonstrated that the modulation of the plant protein synthesis machinery enhances hEPO production. Co‐expression of basic leucine zipper transcription factors with hEPO prevents plant tissue damage, boosts expression, and increases hEPO solubility. bZIP28 co‐expression up‐regulates genes associated with the unfolded protein response, indicating that the plant tissue damage caused by hEPO expression is due to the native protein folding machinery being overwhelmed and that this can be overcome by co‐expressing bZIP28.
The fluorescence mKate2 labeling as a visualizing system for monitoring small extracellular vesicles
Authors: Mao Kedan , Lv Youheng , Huo FangFang , Hu Enchang , Zhang Rui , Fu Yuxuan 
Published: May 2024

AbstractSmall extracellular vesicles (sEVs) are nanosized vesicles enclosed in a lipid membrane released by nearly all cell types. sEVs have been considered as reliable biomarkers for diagnostics and effective carriers. Despite the clear importance of sEV functionality, sEV research faces challenges imposed by the small size and precise imaging of sEVs. Recent advances in live and high‐resolution microscopy, combined with efficient labeling strategies, enable us to investigate the composition and behavior of EVs within living organisms. Here, a modified sEVs was generated with a near infrared fluorescence protein mKate2 using a VSVG viral pseudotyping‐based approach for monitoring sEVs. An observed was made that the mKate2‐tagged protein can be incorporated into the membranes of sEVs without altering their physical properties. In vivo imaging demonstrates that sEVs labeled with mKate2 exhibit excellent brightness and high photostability, allowing the acquisition of long‐term investigation comparable to those achieved with mCherry labeling. Importantly, the mKate2‐tagged sEVs show a low toxicity and exhibit a favorable safety profile. Furthermore, the co‐expression of mKate2 and rabies virus glycoprotein (RVG) peptide on sEVs enables brain‐targeted visualization, suggesting the mKate2 tag does not alter the biodistribution of sEVs. Together, the study presents the mKate2 tag as an efficient tracker for sEVs to monitor tissue‐targeting and biodistribution in vivo.
Treatment confidence and patient participation in multidisciplinary tumor conferences: A structural equation modeling approach
Authors: Degenhardt Marie , Ernstmann Nicole , Schellenberger Barbara , Ansmann Lena , Heuser Christian 
Published: May 2024

AbstractObjectiveMultidisciplinary tumor conference (MTC) is a key instrument in multidisciplinary cancer care. In recent years, if and how patient participation in MTC can contribute to a more patient‐centered care have been scientifically discussed. This study aimed to identify determinants of treatment confidence in the context of patient participation in MTC. Therefore, the association among health literacy‐sensitive communication, trust in health‐care providers (HCP), and treatment confidence is examined.MethodsThis study used data from the multicenter, observational study “PINTU” on patient participation in MTC. Data were collected from November 2018 to February 2020. Validated scales for treatment confidence, health literacy‐sensitive communication, and trust in providers were included in the structural equation modeling (SEM) analysis.ResultsA total of 95 patients participated in MTC. The sample compromised n = 80 completed datasets. The SEM fit measures indicated good fit of the proposed model. The analysis showed a positive association between health literacy‐sensitive communication and treatment confidence when adding the mediating effect of trust in providers.ConclusionPatient‐centered communication during MTC in combination with a trustful relationship between participating patients and health‐care providers is positively associated with treatment confidence. The results indicated the relevance of a trustful doctor–patient communication and relationship. Trainings for physicians targeting patient‐centered communication could be a promising approach to strengthen patient participation.
Aldehyde dehydrogenase 1 family: A potential molecule target for diseases
Authors: Duan Xiangning , Hu Haoliang , Wang Lingzhi , Chen Linxi 
Published: May 2024

AbstractAldehyde dehydrogenase 1 (ALDH1), a crucial aldehyde metabolizing enzyme, has six family members. The ALDH1 family is expressed in various tissues, with a significant presence in the liver. It plays a momentous role in several pathophysiological processes, including aldehyde detoxification, oxidative stress, and lipid peroxidation. Acetaldehyde detoxification is the fundamental function of the ALDH1 family in participating in vital pathological mechanisms. The ALDH1 family can catalyze retinal to retinoic acid (RA) that is a hormone‐signaling molecule and plays a vital role in the development and adult tissues. Furthermore, there is a need for further and broader research on the role of the ALDH1 family as a signaling molecule. The ALDH1 family is widely recognized as a cancer stem cell (CSC) marker and plays a significant role in the proliferation, invasion, metastasis, prognosis, and drug resistance of cancer. The ALDH1 family also participates in other human diseases, such as neurodegenerative diseases, osteoarthritis, diabetes, and atherosclerosis. It can inhibit disease progression by inhibiting/promoting the expression/activity of the ALDH1 family. In this review, we comprehensively analyze the tissue distribution, and functions of the ALDH1 family. Additionally, we review the involvement of the ALDH1 family in diseases, focusing on the underlying pathological mechanisms and briefly talk about the current status and development of ALDH1 family inhibitors. The ALDH1 family presents new possibilities for treating diseases, with both its upstream and downstream pathways serving as promising targets for therapeutic intervention. This offers fresh perspectives for drug development in the field of disease research.
Free intraperitoneal air in infected pancreatic necrosis with intraperitoneal rupture: A rare presentation of a complex diseases
Authors: Kejela Segni , Ager Genet , Gebremariam Meklit Solomon 
Published: May 2024

Key Clinical MessageAmong the multitude of causes for acute abdomen patients presenting with free intraperitoneal air, one almost never finds infected pancreatic necrosis as one of the culprits. In patients with risk factors for acute pancreatitis presenting with generalized peritonitis with free intraperitoneal air, consideration should be given to this often deadly entity.AbstractAcute pancreatitis is a morbid acute abdominal pathology that has been increasing in incidence in recent years. Most patients have a mild disease and treated medically, while a few proportion require interventional procedures. We present the case of a 39‐year‐old male patient who presented with progressive abdominal pain, vomiting, and yellowish discoloration of the eyes. The abdominal condition progressed to the point where clinical signs became consistent with generalized peritonitis and an x‐ray finding of free intraperitoneal air. The patient underwent exploratory laparotomy with intraoperative findings of intraperitoneal rupture of infected pancreatic necrosis with intraperitoneal purulent collection. He was managed with necrosectomy and discharged improved after intensive care and general ward stay.
Enantioselective Synthesis of Dihydrobenzofurans, Dihydrobenzosulfones, and Dihydroindoles by Merging One‐pot Intramolecular Heck‐Matsuda Reactions from Anilines with Redox‐Relay Process
Authors: Scarpa de Souza Edson Leonardo , Gorbatov Sergei Aleksandrovich , Pierozzi Breno Mendes , Batista Junior João Marcos , Duarte Correia Carlos Roque 
Published: May 2024

AbstractA one‐pot tandem process was developed aiming at the concise and expeditious enantioselective synthesis of dihydrobenzofuran, dihydrobenzosulfone, and dihydroindole scaffolds under mild, and open‐flask conditions. This process combines the in situ generation of aryldiazonium salt directly from the anilines in methanol telescoped to an intramolecular Heck‐Matsuda reaction linked to a redox relay process to provide the final products as the dimethyl acetals. These Heck products were smoothly converted into the corresponding primary alcohols or esters. The robustness and the efficiency of the protocol are demonstrated by the synthesis of 24 enantioenriched dihydrobenzofurans, dihydrobenzosulfones, and dihydroindoles in overall yields up to 78 % in enantiomeric ratios up to 99 : 1 by a sequential 5‐step protocol.
Photo‐ and Stress‐Induced Bending of (E)‐1,2‐Bis(pyridinium‐4‐yl)ethene Dinitrate Crystals
Authors: Kusumoto Sotaro , Wakabayashi Kaede , Rakumitsu Kenta , Harrowfield Jack , Kim Yang , Koide Yoshihiro 
Published: May 2024

AbstractWe report on the elastic and photodynamic properties of (E)‐1,2‐bis(pyridinium‐4‐yl)ethene dinitrate [H2Ebpe](NO3)2, whose needle‐like crystals can be reversibly deformed by applying external mechanical stress. The macro‐scale mechanical properties of [H2Ebpe](NO3)2 crystals were quantified by a three‐point bending test, which gave a stress‐strain curve with an elastic modulus of 1.18 GPa, and its values are lower than those of other flexible elastic organic crystals. It can also be reversibly bent through the [2+2] cycloaddition reaction of the olefin moiety, depending on the direction of UV irradiation.
Multicolor Anti‐counterfeiting Strategy and Synchronous High Capacity Storage Based on Acidochromic Organic Fluorescent Materials
Authors: Fang Ying , Luan Jun‐Yu , Liu Li‐Hao , Huang Ying‐Qing , Luo Yi‐Ning , Wang Kun‐Peng , Chen Shaojin , Hu Hai‐Yu , Hu Zhi‐Qiang 
Published: May 2024

Comprehensive SummaryMany industries are plagued by economic losses and product failures caused by counterfeit goods. Therefore, advanced anti‐counterfeiting techniques are continuously needed. In this study, we constructed a series of acid‐base sensitive cyclic chalcone dyes A—F by modifying different electron‐donating groups. Differences in acid sensitivity of different structures are well rationalised by NMR and theoretical calculations. Aniline is difficult to protonate than fatty amines, so there is a difference in fluorescence. Hiding and anti‐counterfeiting of information is achieved by this phenomenon. Powder X and Y are the anti‐counterfeit fluorescent powder containing montmorillonite and cyclic chalcone, which have orange fluorescence and the very similar appearance. However, under the influence of acid the Powder X containing triphenylamine modified cyclic chalcone shows red shifted fluorescence and Powder Y containing morpholino and diethylamino groups modified cyclic chalcone shows blue shifted fluorescence. Therefore, the anti‐counterfeiting strategy based on cyclic chalcone is not only limited to UV‐irradiated fluorescence development, but also has more colorization and pattern variations with the aid of acid developer. Data encryption and decryption of numbers, English alphabets and Chinese characters have been realized using A—F, which have great potential for practical applications.
Chiral Isothiourea‐Catalyzed Acylative Dynamic Kinetic Resolution of 3‐Hydroxyphthalides for Enantioselective Synthesis of Phthalidyl Esters
Authors: Hao Zeyang , Lin Wei , Yuan Zi‐Qi , Zhang Wei , Li Xin 
Published: May 2024

Comprehensive SummaryPhthalides serve as core structures pervasive in a wide array of natural products and drug molecules, which display a diverse array of biological activities. We report herein a highly efficient dynamic kinetic resolution of 3‐hydroxyphthalides by chiral isothioureas (ITUs) catalyzed asymmetric acylation, facilitating the effective synthesis of a variety of chiral phthalidyl esters with good yields and enantioselectivities. Notably, this reaction features mild reaction conditions, expansive substrate scope as well as good functional group compatibility. In addition, the practicality of this method is underscored by the large‐scale synthesis, reduced catalyst loading experiment and the synthesis of the chiral phthalidyl ester prodrug.
Safety of ultra‐low contrast coronary angiography in patients with acute kidney injury
Authors: Rozenbaum Zach , Chang Mailing Flores , Wiley Jose , Gholam Ali , Irimpen Anand , Alsaad Ali A. 
Published: May 2024

AbstractBackgroundUltra‐low contrast administration during coronary angiography has been previously shown to be feasible and safe among patients with stable chronic kidney disease. In the present study, we investigate the safety of ultra‐low contrast coronary angiography in patients with pre‐existing acute kidney injury (AKI).MethodsThe study was a retrospective single‐center evaluation of hospitalized patients who had AKI and required coronary angiography. Ultra‐low contrast use was defined as ≤18 mL of contrast media.ResultsThe cohort consisted of a case series of eight inpatients with AKI who required coronary angiography. The mean age was 57 (±16) years and half were females. All patients had chronic kidney disease with a mean baseline estimated glomerular filtration rate of 34 (±17) mL/min/1.73 m2. The mean creatinine before angiography was 3 (±1) mg/dL and volume of contrast administered was 14 (±4) mL. One patient had a 0.1 mg/dL increase in creatinine during admission, and no patients had further AKI up to 1‐week postprocedure.ConclusionsThe current data suggest that ultra‐low contrast coronary angiography can be safely performed in patients with pre‐existing AKI The study should be viewed as hypothesis‐generating due to its small sample size. A larger cohort is required to validate the results.
Chitosan as Support Material for Metal‐Organic Framework based Catalysts
Authors: Jabbour Christia R. , Schnabl Kordula B. , Yan Haoxiang , O'Beirn Naoise N. , Dorresteijn Joren M. , Meirer Florian , Mandemaker Laurens D. B. , Weckhuysen Bert M. 
Published: May 2024

AbstractTurning waste into valuable products is one of the main challenges of the chemical industry. In this work, chitosan (CS), an abundant, low‐cost, and non‐toxic biopolymer derived from chitin, was reshaped into beads of ~3 mm. Their suitability as a support material for active phase catalyst materials was tested for a zirconium‐based Metal‐Organic Framework (MOF) with incorporated Pt, namely UiO‐67‐Pt. Its incorporation was investigated via two procedures: a one‐pot synthesis (OPS) and a post‐synthetic functionalization (PSF) synthesis method. Scanning electron microscopy (SEM) images show good UiO‐67‐Pt dispersion throughout the CS beads for the one‐pot synthesized material (UiO‐67‐Pt‐OPS@CS). However, this uniform dispersion was not observed for the post‐synthetically functionalized material (UiO‐67‐Pt‐PSF@CS). The success of the implementation of UiO‐67‐Pt was evaluated with ultraviolet‐visible and infrared spectroscopy for both composite materials. Thermogravimetric analysis (TGA) reveals higher thermal stabilities for UiO‐67‐Pt‐OPS@CS composite beads in comparison to pure CS beads, but not for UiO‐67‐Pt‐PSF@CS. The study provides valuable insights into the potential of chitosan as a green, bead‐shaped support material for MOFs, offering flexibility in their incorporation through different synthesis routes. It further contributes to the broader goal of the sustainable and eco‐friendly design of a new generation of catalysts made from waste materials, which will be the topic of future studies.