bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Transparent Sand for Geotechnical Laboratory Modeling
Authors: Ezzein Fawzy M. , Bathurst Richard J. 
Published: August 2011

AbstractThe paper describes a new transparent granular soil that can be used for laboratory geotechnical modeling purposes. The transparent soil consists of fused quartz particles in combination with a mixture of two mineral oils as pore fluid. The solid particles and the matching liquid have the same refractive index. The soil has important advantages with respect to transparency, stability, health safety, and utility over glass and silica gel materials. The transparent soil is also inexpensive compared to silica gel-fluid materials that have been used in the past. Conventional laboratory shear box, triaxial compression, and permeability tests were carried out to demonstrate that the mechanical properties and hydraulic permeability of the transparent soil are typical of granular soils with angular particles.
NSF 14: Shaping the Future of the Plastic Piping Industry
Authors: Ciechanowski Ata 
Published: August 2011

Abstract
In 1951, NSF, then the National Sanitation Foundation, was approached by the Thermoplastics division of the Society of the Plastics Industry to initiate a research study related to the suitability of plastic pipe for potable water supplies. The results were reported in 1955 under the title “A Study of Plastic Pipe for Potable Water Supplies.” Following the publication of the study, NSF was requested by the plastics industry to establish a continuing testing and certification program on plastics materials, pipe, and fittings for potable water applications not only for toxicological considerations but also for performance evaluation. The Public Health and Industry Advisory Committee recommended the use of ASTM test procedures. The certification program was first started in 1959 and led to the creation of National Sanitation Foundation Standard Number 14 for Thermoplastic Materials in 1965. In 1991, NSF 14 became ANSI/NSF 14, the national standard for Plastic Piping Systems Components and Related Materials.
Reconditioning of self-ligating brackets
Authors: Sfondrini Maria Francesca , Xheka Esmeralda , Scribante Andrea , Gandini Paola , Sfondrini Giuseppe 
Published: August 2011

Abstract

Objective:
To test the null hypothesis that there is no significant difference in the shear bond strength (SBS) and Adhesive Remnant Index (ARI) scores of new vs reconditioned self-ligating brackets.

Materials and Methods:
One hundred and twenty permanent extracted bovine teeth were embedded in resin blocks. Three different new and reconditioned self-ligating orthodontic brackets (Smart Clip [3M Unitek]; Quick [Forestadent]; and Damon3MX [Ormco]) were tested. Scanning electron microphotographs of the different new (groups 1, 3, and 5) and reconditioned (groups 2, 4, and 6) bracket bases were taken before starting the experiments. Brackets were then bonded to the teeth using an orthodontic adhesive and were then tested in shear mode using an Instron Universal Testing Machine. ARI scores were then recorded. Statistical analysis was performed to determine significant differences in SBS and ARI Scores.

Results:
Smart Clip and Damon3MX reconditioned brackets showed significantly lower SBS than did new ones. On the contrary, Quick reconditioned brackets showed significantly higher SBS than did new ones. No significant differences in ARI scores were found after the reconditioning process for the three different brackets tested.

Conclusion:
The in-office reconditioning procedure alters the SBS of self-ligating brackets, although SBS values still remain clinically acceptable.
Evaluation of plasma islet amyloid polypeptide and serum glucose and insulin concentrations in nondiabetic cats classified by body condition score and in cats with naturally occurring diabetes mellitus
Authors: Henson Michael S. , Hegstad-Davies Rebecca L. , Wang Qi , Hardy Robert M. , Armstrong P. Jane , Jordan Kathryn , Johnson Kenneth H. , O'Brien Timothy D. 
Published: August 2011

Abstract
Objective—To evaluate and compare circulating concentrations of islet amyloid polypeptide (IAPP), insulin, and glucose in nondiabetic cats classified by body condition score (BCS) and in cats with naturally occurring diabetes mellitus.
Animals—109 (82 nondiabetic, 21 nonketoacidotic diabetic, and 6 ketoacidotic diabetic) cats.
Procedures—Cats were examined and BCSs were assessed on a scale of 1 to 9. After food was withheld for 12 hours, blood was collected and plasma concentrations of IAPP and serum concentrations of insulin and glucose were measured. Differences in these values were evaluated among nondiabetic cats grouped according to BCS and in diabetic cats grouped as ketoacidotic or nonketoacidotic on the basis of clinicopathologic findings. Correlations were determined among variables.
Results—In nondiabetic cats, BCS was significantly and positively correlated with circulating IAPP and insulin concentrations. Mean plasma IAPP concentrations were significantly different between cats with BCSs of 5 and 7, and mean serum insulin concentrations were significantly different between cats with BCSs of 5 and 8. Serum glucose concentrations were not significantly different among nondiabetic cats. Mean IAPP concentrations were similar between nonketoacidotic diabetic cats and nondiabetic cats with BCSs of 8 or 9. Mean IAPP concentrations were significantly reduced in ketoacidotic diabetic cats, compared with those of nondiabetic cats with BCSs of 6 through 8 and of nonketoacidotic diabetic cats.
Conclusions and Clinical Relevance—Results indicated that increased BCS (a measure of obesity) is associated with increased circulating concentrations of IAPP and insulin in nondiabetic cats.
Evaluation of infectivity of a canine lineage H3N8 influenza A virus in ponies and in primary equine respiratory epithelial cells
Authors: Quintana Ayshea M. , Hussey Stephen B. , Burr Ema C. , Pecoraro Heidi L. , Annis Kristina M. , Rao Sangeeta , Landolt Gabriele A. 
Published: August 2011

Abstract
Objective—To evaluate whether an equine-derived canine H3N8 influenza A virus was capable of infecting and transmitting disease to ponies.
Animals—20 influenza virus-seronegative 12- to 24-month-old ponies.
Procedures—5 ponies were inoculated via aerosol exposure with 107 TCID50 of A/Canine/Wyoming/86033/07 virus (Ca/WY)/pony. A second group of 5 ponies (positive control group) was inoculated via aerosol exposure with a contemporary A/Eq/Colorado/10/07 virus (Eq/CO), and 4 sham-inoculated ponies served as a negative control group. To evaluate the potential for virus transmission, ponies (3/inoculation group) were introduced 2 days after aerosol exposure and housed with Ca/WY- and Eq/CO-inoculated ponies to serve as sentinel animals. Clinical signs, nasal virus shedding, and serologic responses to inoculation were monitored in all ponies for up to 21 days after viral inoculation. Growth and infection characteristics of viruses were examined by use of Madin-Darby canine kidney cells and primary equine and canine respiratory epithelial cells.
Results—Ponies inoculated with Ca/WY had mild changes in clinical appearance, compared with results for Eq/CO-inoculated ponies. Additionally, Ca/WY inoculation induced significantly lower numbers for copies of the matrix gene in nasal secretions and lower systemic antibody responses in ponies than did Eq/CO inoculation. The Ca/WY isolate was not transmitted to sentinel ponies.
Conclusions and Clinical Relevance—Inoculation of ponies with the canine H3N8 isolate resulted in mild clinical disease, minimal nasal virus shedding, and weak systemic antibody responses, compared with responses after inoculation with the equine H3N8 influenza isolate. These results suggested that Ca/WY has not maintained infectivity for ponies.
Effect of growth on monocarboxylate transporters and indicators of energy metabolism in the gluteus medius muscle of Thoroughbreds
Authors: Kitaoka Yu , Hoshino Daisuke , Mukai Kazutaka , Hiraga Atsushi , Takemasa Tohru , Hatta Hideo 
Published: August 2011

Abstract
Objective—To examine the changes in monocarboxylate transporter (MCT) 1 and MCT4 content and in indicators of energy metabolism in the gluteus medius muscle (GMM) of Thoroughbreds during growth.
Animals—6 Thoroughbreds (3 males and 3 females).
Procedures—Samples of GMM were obtained when horses were 2, 6, 12, and 24 months old. Muscle proteins were separated via SDS-PAGE; amounts of MCT1 and MCT4 and peroxisome proliferator-activated receptor-γ coactivator-1α content were determined by use of western blotting. Muscle activities of phosphofructokinase and citrate synthase were measured biochemically; lactate dehydrogenase isoenzymes were separated by agarose gel electrophoresis and quantified.
Results—Compared with findings when horses were 2 months old, MCT1 protein content in GMM samples obtained when the horses were 24 months old was significantly higher; however, MCT4 protein content remained unchanged throughout the study period. Peroxisome proliferator-activated receptor-γ coactivator-1α content was significantly increased at 24 months of age and citrate synthase activity was increased at 6 and 24 months of age, compared with findings at 2 months. Phosphofructokinase activity remained unaltered during growth. The percentage contributions of lactate dehydrogenase 1 and 2 isoenzymes to the total amount of all 5 isoenzymes at 12 and 24 months of age were significantly higher than those at 2 months of age.
Conclusions and Clinical Relevance—Changes in protein contents of MCTs and the lactate dehydrogenase isoenzyme profile in GMM samples suggested that lactate usage capacity increases with growth and is accompanied by an increase in the oxidative capacity in Thoroughbreds.
In vitro comparison of stiffness of plate fixation of radii from large- and small-breed dogs
Authors: Gauthier Christopher M. , Conrad Bryan P. , Lewis Daniel D. , Pozzi Antonio 
Published: August 2011

Abstract
Objective—To compare in vitro axial compression, abaxial compression, and torsional stiffnesses of intact and plated radii from small- and large-breed dogs.
Sample—Radii from 18 small-breed and 9 large-breed skeletally mature dogs.
Procedures—3 groups were tested: large-breed dog radii plated with 3.5-mm limited-contact dynamic compression plates (LCDCPs), small-breed dog radii plated with 2.0-mm dynamic compression plates (DCPs), and small-breed dog radii plated with 2.0/2.7-mm cut-to-length plates (CTLPs). The axial compression, abaxial compression, and torsional stiffnesses of each intact radius were determined under loading with a material testing machine. An osteotomy was performed, radii were plated, and testing was repeated. The stiffness values of the plated radii were expressed as absolute and normalized values; the latter was calculated as a percentage of the stiffness of the intact bone. Absolute and normalized stiffness values were compared among groups.
Results—The absolute stiffnesses of plated radii in axial and abaxial compression were 52% to 83% of the intact stiffnesses in all fixation groups. No difference was found in torsion. There was no difference in normalized stiffnesses between small-breed radii stabilized with CTLPs and large-breed radii stabilized with LCDCPs; however, small-breed radii stabilized with DCPs were less stiff than were any other group.
Conclusions and Clinical Relevance—Plated radii of small-breed dogs had normalized stiffnesses equal to or less than plated radii of large-breed dogs. The complications typically associated with plating of radial fractures in small-breed dogs cannot be ascribed to an overly stiff bone-plate construct.
Humoral immunity and injection-site reactions in cattle vaccinated with a multivalent clostridial vaccine administered via subcutaneous injection or via transdermal needle-free injection
Authors: Woolums Amelia R. , Ensley Douglas T. , Tanner Patrick A. , Fankhauser Rebecca , Shen Jing , Songer J. Glenn , Leard A. Timothy , Milward Francis W. , Pence Mel E. , Hurley David J. 
Published: August 2011

Abstract
Objective—To evaluate injection-site reactions and serum antibody titers in cattle vaccinated with a clostridial vaccine administered SC or via needle-free transdermal injection.
Animals—Sixteen 11-to 12-month-old Herefords.
Procedures—Cattle in 2 groups were vaccinated on days 0 and 28 with a commercially available multivalent clostridial vaccine administered SC or transdermally Injection sites and serum antibody titers were evaluated at several time points after vaccination. Serum antibody titers against Clostridium perfringens beta toxin, Clostridium novyi alpha toxin, and Clostridium septicum alpha toxin were determined with an ELISA; Clostridium sordellii lethal toxin titers were determined with a toxin neutralization assay.
Results—Firm injection site swellings developed in cattle vaccinated via either route; however, at several observation times, swellings were significantly smaller in cattle vaccinated transdermally. Serum titers against C perfringens beta toxin and C septicum alpha toxin did not differ significantly between groups after vaccination; serum titers against C novyi alpha toxin were not significantly different between groups, except on days 10 and 56, when they were significantly higher in cattle vaccinated SC. Titers against C sordellii lethal toxin were significantly higher in cattle vaccinated SC on several days after vaccination, but titers were not significantly different after day 49.
Conclusions and Clinical Relevance—Transdermal vaccination of cattle resulted in serum antibody titers that were similar to those induced via SC vaccination and caused injection-site reactions that were significantly smaller. Transdermal vaccination may be an effective technique for vaccinating cattle against clostridial diseases while minimizing local reactions that often develop after clostridial vaccination.
Gender differences in salary and practice ownership expectations of matriculating veterinary students
Authors: Bristol David G. 
Published: August 2011

Abstract
Objective—To examine gender differences in initial and long-term salary and practice ownership expectations among first-year veterinary students.
Design—Survey.
Sample—First-year veterinary students at the North Carolina State University College of Veterinary Medicine during 2000 through 2003 and 2005 through 2009.
Procedures—A 1-page survey was distributed to students during orientation exercises or on the first day of a first-year course on ethics and jurisprudence. Students were asked to indicate their expected salary at graduation and in 5-year increments after graduation and to indicate whether they expected to own a practice after graduation.
Results—Responses were obtained from 567 female and 120 male students. There was no significant difference in initial salary expectations between male and female students. However, men had higher expectations for salary increases over the course of their career, so that expected salary was significantly higher for men than for women 5 years after graduation and beyond. A significantly greater percentage of men (69/93 [74.2%]) than women (242/499 [48.5%]) indicated they expected to own a practice.
Conclusions and Clinical Relevance—Although male and female veterinary students had similar expectations with regard to initial salaries, the male students had higher long-term salary expectations and were more likely to indicate an expectation to become a practice owner. Differences in expectations may lead to differences in behavior when those expectations are or are not met.
Treatment and survival of patients with nonmalignant intracranial meningioma: results from the Surveillance, Epidemiology, and End Results Program of the National Cancer Institute
Authors: Cahill Kevin S. , Claus Elizabeth B. 
Published: August 2011

Object
The authors conducted a study to determine population-based estimates of survival following the diagnosis and treatment of nonmalignant intracranial meningioma in the US in the modern era.

Methods
Patients with nonmalignant intracranial meningioma were identified through the Surveillance, Epidemiology, and End Results (SEER) database for the years 2004–2007. Predictors of undergoing resection were identified and odds ratios calculated. Estimates of survival were calculated using Kaplan-Meier estimation method and Cox proportional hazards model.

Results
There were 12,284 patients with a diagnosis of nonmalignant intracranial meningioma included in the analysis. Only 55% had histological confirmation of the diagnosis of nonmalignant meningioma. Resection was used as an initial treatment in 43% of cases. Patients treated with surgery were more likely to be younger (OR 9.3, 95% CI 8.1–10.7, for resection in patients age 40–59 years compared with age > 80 years), male (OR 1.4, 95% CI 1.3–1.5, for males compared with females), white (OR 0.8, 95% CI 0.7–0.9, for black patients compared with white patients), and have larger tumors (OR 11.8, 95% CI 10.3–13.6, for tumors of the largest quartile compared with the smallest quartile). Patients treated with resection had a 3-year postdiagnosis survival estimate of 93.4% (95% CI 92.5%–94.3%) compared with 88.3% (95% CI 85.5%–90.6%) in patients not treated with resection (p < 0.01). Younger patient age, female sex, unilateral tumors, and resection were predictors of improved postdiagnosis survival after multivariate adjustment in patients with histologically confirmed meningiomas.

Conclusions
This analysis represents the first modern population-based analysis of treatment patterns and outcomes in US patients with nonmalignant intracranial meningioma. Over 85% of patients survive 3 years after diagnosis, and resection is associated with improved survival.
Endoscopy versus microsurgical cyst excision and shunting for treating intracranial arachnoid cysts
Authors: Gangemi Michelangelo , Seneca Vincenzo , Colella Giuseppe , Cioffi Valentina , Imperato Alessia , Maiuri Francesco 
Published: August 2011

Object
Endoscopic surgery is routinely used to treat intracranial arachnoid cysts. However, the indications and results with respect to the different cyst locations, compared with those of microsurgical fenestration and cyst shunting, deserve to be discussed.

Methods
The authors review 18 patients with intracranial arachnoid cysts treated by pure endoscopic technique in their neurosurgical department. There were 10 male and 8 female patients ranging in age from 2 months to 48 years (median age 19.4 years). The cyst location was suprasellar in 5 cases, quadrigeminal in 5, cortical hemispheric in 2, sylvian region in 3, and posterior fossa in 3. The authors also reviewed the literature, comprising 61 reports for an overall number of 645 patients with intracranial arachnoid cysts treated by different surgical techniques. These techniques included microsurgical excision or fenestration by craniotomy, cyst shunting, and endoscopic fenestration. The surgical results of the different techniques according to the different cyst locations underwent statistical analysis.

Results
The overall success rate (complete or partial clinical remission) in the authors' endoscopic series was 83.3% (15 of 18 cases), which is rather similar to that of 222 patients treated endoscopically and reported on in the literature (84.2%). In the overall endoscopic group, a higher success rate was found for cysts in the suprasellar (89.7%), quadrigeminal (88.5%), and posterior cranial fossa (83.3%) regions compared with sylvian (70%) and cortical and interhemispheric (75%) regions. The statistical comparison of the results of the endoscopic series with those of craniotomy and shunting revealed no significant differences for suprasellar, quadrigeminal, or posterior cranial fossa cysts, whereas the success rate of endoscopy is lower than that of other techniques for sylvian and cortical cysts.

Conclusions
Endoscopy is a safe and effective therapeutic modality for patients with intracranial arachnoid cysts. Cysts of the suprasellar and quadrigeminal regions and posterior fossa are the best indications for neuroendoscopy; on the other hand, cortical cysts are best treated by microsurgical fenestration or shunting. For sylvian cysts, the endoscopic procedure may be advocated in most cases.
OARSI/OMERACT Initiative to Define States of Severity and Indication for Joint Replacement in Hip and Knee Osteoarthritis. An OMERACT 10 Special Interest Group
Authors: GOSSEC LAURE , PATERNOTTE SIMON , BINGHAM CLIFTON O. , CLEGG DANIEL O. , COSTE PHILIPPE , CONAGHAN PHILIP G. , DAVIS AILEEN M. , GIACOVELLI GIAMPAOLO , GUNTHER KLAUS-PETER , HAWKER GILLIAN , HOCHBERG MARC C. , JORDAN JOANNE M. , KATZ JEFFREY N. , KLOPPENBURG MARGREET , LANZAROTTI ARTURO , LIM KEITH , LOHMANDER L. STEFAN , MAHOMED NIZAR N. , MAILLEFERT JEAN FRANCIS , MANNO REBECCA L. , MARCH LYN M. , MAZZUCA STEVEN A. , PAVELKA KAREL , PUNZI LEONARDO , ROOS EWA M. , ROVATI LUCIO C. , SHI HELEN , SINGH JASVINDER A. , SUAREZ-ALMAZOR MARIA E. , TAJANA-MESSI ELEONORA , DOUGADOS MAXIME 
Published: August 2011

Objective.To define pain and physical function cutpoints that would, coupled with structural severity, define a surrogate measure of “need for joint replacement surgery,” for use as an outcome measure for potential structure-modifying interventions for osteoarthritis (OA).Methods.New scores were developed for pain and physical function in knee and hip OA. A cross-sectional international study in 1909 patients was conducted to define data-driven cutpoints corresponding to the orthopedic surgeons’ indication for joint replacement. A post hoc analysis of 8 randomized clinical trials (1379 patients) evaluated the prevalence and validity of cutpoints, among patients with symptomatic hip/knee OA.Results.In the international cross-sectional study, there was substantial overlap in symptom levels between patients with and patients without indication for joint replacement; indeed, it was not possible to determine cutpoints for pain and function defining this indication. The post hoc analysis of trial data showed that the prevalence of cases that combined radiological progression, high level of pain, and high degree of function impairment was low (2%–12%). The most discriminatory cutpoint to define an indication for joint replacement was found to be [pain (0–100) + physical function (0–100) > 80].Conclusion.These results do not support a specific level of pain or function that defines an indication for joint replacement. However, a tentative cutpoint for pain and physical function levels is proposed for further evaluation. Potentially, this symptom level, coupled with radiographic progression, could be used to define “nonresponders” to disease-modifying drugs in OA clinical trials.
On Differential Gene expression Using RNA-Seq Data
Authors: Lee Juhee , Ji Yuan , Liang Shoudan , Cai Guoshuai , Müller Peter 
Published: August 2011

Motivation RNA-Seq is a novel technology that provides read counts of RNA fragments in each gene, including the mapped positions of each read within each gene. Besides many other applications it can be used to detect differentially expressed genes. Most published methods collapse the position-level read data into a single gene-specific expression measurement. Statistical inference proceeds by modeling these gene-level expression measurements. Results We present a Bayesian method of calling differential expression (BM-DE) that directly models the position-level read counts. We demonstrate the potential advantage of the BM-DE method compared to existing approaches that rely on gene-level aggregate data. An important additional feature of the proposed approach is that BM-DE can be used to analyze RNA-Seq data from experiments without biological replicates. This becomes possible since the approach works with multiple position-level read counts for each gene. We demonstrate the importance of modeling for position-level read counts with a yeast data set and a simulation study. Availability A public domain R package is available from http://odin.mdacc.tmc.edu/~ylji/BMDE/ .