bluuebunny/crossref_metadata_2025_split huggingface dataset:
ChemInform Abstract: Synthesis of New 3,3′‐(1,4‐Phenylene)bis(1,5‐diones) Derivatives.
Authors: Shao Qiang , Liu Hui , Wang Ting‐Ting , Zeng He‐Ping 
Published: March 2012

AbstractTitle compounds of type (IV) (5 examples) are prepared under optimized conditions.
ChemInform Abstract: Metal‐Free Synthesis of Polysubstituted Pyrroles by (Diacetoxyiodo)Benzene‐Mediated Cascade Reaction of 3‐Alkynyl Amines.
Authors: Mo Dong‐Liang , Ding Chang‐Hua , Dai Li‐Xin , Hou Xue‐Long 
Published: March 2012

AbstractA variety of bis‐ and tri‐‐substituted pyrroles is prepared.
ChemInform Abstract: A Hg(ClO4)2·3H2O‐Catalyzed Sakurai—Hosomi Allylation of Isatins and Isatin Ketoimines Using Allyltrimethylsilane.
Authors: Cao Zhong‐Yan , Zhang Yan , Ji Cong‐Bin , Zhou Jian 
Published: March 2012

AbstractA wide range of substituted isatins is allylated under aerobic conditions using Hg(ClO4)2·3H2O.
ChemInform Abstract: Nucleophilic Substitution Reaction of Morita—Baylis—Hillman Adducts of Isatin with X, S, N, and O‐Nucleophiles: A Facile and Efficient Synthesis of Highly Functionalized Tetrasubstituted Alkene Appended Oxindoles.
Authors: Solaiselvi Rajarethinam , Mandal Asit Baran , Shanmugam Ponnusamy 
Published: March 2012

AbstractThe substitution reactions are investigated in order to produce novel derivatives of the biologically important heterocyclic system.
ChemInform Abstract: Coupling of Two Diazotized 3‐Aminothieno[3,4‐c]coumarins with Aromatic Amines.
Authors: Fondjo Emmanuel Sopbue , et al. et al. 
Published: March 2012

AbstractThe coupling reaction of diazotized 3‐aminothieno[3,4‐c]coumarins with aromatic amines provides access to arylazothiophene dyes in form of their ammonium sulfate salts.
ChemInform Abstract: Zr(HSO4)4‐Catalyzed One‐Pot Three‐Component Synthesis of 7‐Alkyl‐6H,7H‐naphtho[1′,2′:5,6]pyrano[3.2‐c]chromen‐6‐ones.
Authors: Wang Xiao , Lu Guangzhou , Yan Fulin , Ma Weiwei , Wu Liqiang 
Published: March 2012

AbstractThe advantages of the method are high yields, a simple procedure, short reaction times and the easy work‐up.
ChemInform Abstract: A Facile and Efficient Addition Reaction of Nitrogen‐Containing Heterocyclic Compounds with DMAD under Neat Conditions.
Authors: Valizadeh Hassan , Shomali Ashkan , Gholipour Hamid 
Published: March 2012

AbstractOptimum conditions are examined for the reaction of several nitrogen‐containing heterocycles with dimethyl acetylenedicarboxylate.
ChemInform Abstract: Synthesis, Structure and Properties of Benzo[1,2‐f:5,4‐f′]diquinoline Derivatives: A Remarkably Strong Intramolecular C—H···O Hydrogen Bond.
Authors: Zhang Chun , Peng Xiaoxia , Chen Chuanfeng 
Published: March 2012

AbstractA series of new benzodiquinoline derivatives is synthesized which show remarkably strong intramolecular three‐centered C—H···O hydrogen bond.
ChemInform Abstract: Nicotinic Acids: Liver‐Targeted SCD Inhibitors with Preclinical Antidiabetic Efficacy.
Authors: Powell David A. , et al. et al. 
Published: March 2012

AbstractCompound (VIII) is identified as a liver‐targeting, nicotinic acid‐derived SCD inhibitor that is efficacious in improving glucose clearance in a mouse model.
ChemInform Abstract: Synthesis, Molecular Modelling and Biological Evaluation of 4‐Amino‐2(1H)‐quinazolinone and 2,4(1H,3H)‐Quinazolidone Derivatives as Antitumor Agents.
Authors: Richter Stephanie , Gioffreda Barbara 
Published: March 2012

AbstractVarious 6‐benzoyl‐, 6‐arylthio‐, 6‐arylsulfonyl‐4‐amino‐2(1H)‐quinazolinones, and ‐2,4(1H,3H)‐quinazolinediones are synthesized and screened for their in vitro cytotoxicity against the NCI‐60 cancer cell lines.
ChemInform Abstract: Palladium‐Catalyzed Desulfitative C—H Arylation of Heteroarenes with Sodium Sulfinates.
Authors: Liu Bo , Guo Qiang , Cheng Yangyang , Lan Jingbo , You Jingsong 
Published: March 2012

AbstractInexpensive and air‐stable sodium sulfinates are used as coupling partners to construct aryl—heteroaryl bonds without need for any extra ligands.
ChemInform Abstract: A Facile Synthesis of Novel 1,4‐Benzoxazepin‐2‐one Derivatives.
Authors: Khaleghi Fatemeh , Din Laily Bin , Jantan Ibrahim , Yaacob Wan Ahmad , Khalilzadeh Mohammad A. 
Published: March 2012

AbstractA simple one‐pot three‐component reaction allows the synthesis of title compounds (IV) and (VI).
ChemInform Abstract: Synthesis and α‐Glucosidase Inhibitory, DPPH Scavenging Activity of Substituted 2‐Oxo‐2H‐chromen‐7‐yl‐dihydrogen Phosphate Derivatives.
Authors: Kumar J. Ashok , Tiwari Ashok K. , Ali A. Zehra , Rao R. Ranga , Raju B. China 
Published: March 2012

AbstractA series of coumarin derivatives (VI) is synthesized via Pechmann condensation and subsequent phosphorylation.
ChemInform Abstract: Photochromic and Thermochromic Spiranes. Part 34. Synthesis of Photochromic 5‐(4,5‐Diphenyl‐1,3‐oxazol‐2‐yl)‐Substituted Spirobenzochromeneindolines.
Authors: Voloshin N. A. , Chernyshev A. V. , Metelitsa A. V. , Minkin V. I. 
Published: March 2012

AbstractTitle compounds (I) are synthesized by an improved procedure.
ChemInform Abstract: Chemical Constituents from Sambucus adnata and Their Protein—Tyrosine Phosphatase 1B Inhibitory Activities.
Authors: Sasaki Tatsunori , Li Wei , Morimura Haruna , Li Songpei , Li Qin , Asada Yoshihisa , Koike Kazuo 
Published: March 2012

AbstractThe novel acylated triterpene sambucilate (I) is isolated from the whole plants along with 12 known compounds.
ChemInform Abstract: Sesquiterpenes from the Secondary Metabolites of Streptomyces sp. (YIM 56130)
Authors: Yang Zhi , Yang Yabin , Yang Xueqiong , Zhang Yong , Zhao Lixing , Xu Lihua , Ding Zhongtao 
Published: March 2012

Abstractisolation and structure elucidation of three new sesquiterpenes (I) and (II)
ChemInform Abstract: New Solanocapsine‐Type Tomato Glycoside from Ripe Fruit of Solanum lycopersicum
Authors: Ohno Mizuho , Ono Masateru , Nohara Toshihiro 
Published: March 2012

Abstractisolation and structure of a rare solanocapsine‐type glycoside, esculeoside B‐5 (I)
ChemInform Abstract: Syntheses of L‐Dopa Glycosides Using Glucosidases.
Authors: Vadivelan Ganesan , Divakar Soundar 
Published: March 2012

AbstractAmyloglucosidase catalyzes the reaction of L‐Dopa with various carbohydrate molecules (11 examples) with excellent regioselectivity in some cases, whereas immobilized β‐glucosidase catalyzes only some reactions, however, without any selectivity.
ChemInform Abstract: Synthesis and Biological Evaluation of Antifungal Activities of Novel 1,2‐trans Glycosphingolipids.
Authors: Ding Ning , Zhang Wei , Lv Guokai , Li Yingxia 
Published: March 2012

AbstractA series of 1,2‐trans glycosphingolipids is synthesized and screened for in vitro antifungal activity against Candida albicans, Candida parapsilosis, and Candida tropicalis.
ChemInform Abstract: A Partial Synthesis of 5,8‐O‐Dimethylshikonin (V) and 6‐Isomer of 5,8‐O‐Dimethylshikonin (IV).
Authors: Zheng Xiaogang , Wang Rubing , Zhu Mengyuan , Jing Zheng , Li Shaoshun 
Published: March 2012

AbstractCompared to previous methods, the conditions of the procedure are milder, more environmentally benign and the overall yield is higher.
ChemInform Abstract: Neolignans from Schisandra wilsoniana and Their Antihuman Immunodeficiency Virus‐1 Activities
Authors: Yang Guang‐Yu , Wang Rui‐Rui , Mu Huai‐Xue , Li Yin‐Ke , Xiao Wei‐Lie , Yang Liu‐Meng , Pu Jian‐Xin , Zheng Yong‐Tang , Sun Han‐Dong 
Published: March 2012

Abstractisolation, structure and anti‐HIV activities of marphenols G—J
ChemInform Abstract: Recent Advances on the Synthesis of Piperidines Through Ruthenium‐Catalyzed Ring‐Closing Metathesis (RCM) Reactions
Authors: Merino Pedro , Tejero Tomas , Greco Graziella , Marca Eduardo , Delso Ignacio , Gomez‐SanJuan Asier , Matute Rosa 
Published: March 2012

AbstractReview: 130 refs.
ChemInform Abstract: Liquid—Liquid Equilibria of Ternary Systems Composed of Ionic Liquid and Aromatic and Aliphatic Hydrocarbons, and Their Modeling by COSMO‐RS
Authors: Ferreira Ana R. , Freire Mara G. , Ribeiro Jorge C. , Lopes Fernando M. , Crespo Joao G. , Coutinho Joao A. P. 
Published: March 2012

AbstractReview: 95 refs.
ChemInform Abstract: Design of Functionalized Room‐Temperature Ionic Liquid Based Materials for CO2 Separations and Selective Blocking of Hazardous Chemical Vapors
Authors: Miller A. L. , Carlisle T. K. , LaFrate A. L. , Voss B. A. , Bara J. E. , Hudiono Y. C. , Wiesenauer B. R. , Gin D. L. , Noble R. D. 
Published: March 2012

AbstractReview: 41 refs.
A new digital control method for a voltage source inverter to compensate for imbalance of output voltage
Authors: Wang Jian‐Min , Tseng Po‐Jung , Yen Shang‐Chin , Liu Pang‐Jung , Chiu Huang‐Jen 
Published: March 2012

ABSTRACTThis paper provides a new signal compensation method for digital inverters, which is aimed at improving the voltage source inverter. Because of the non‐ideal characteristics of components of the inverter (e.g., metal oxide semiconductor field‐effect transistor module), the output voltage is unequal at positive and negative half cycles. This will result in inductive load saturation, and the switches will be damaged. The method proposed in this paper utilizes a combination of pulse signal and reference signal for adjusting the height and the width of pulse signal, with small direct current offset compensated by the average voltage of the signal. This method can also be adopted in a built‐in, low‐resolution pulse width modulation digital controller, which has advantages such as automatic compensation of output voltage and low cost. Copyright © 2012 John Wiley & Sons, Ltd.
Preparation of Imidazolidin‐4‐ones and Their Evaluation as Hydrolytically Cleavable Precursors for the Slow Release of Bioactive Volatile Carbonyl Derivatives
Authors: Trachsel Alain , Buchs Barbara , Godin Guillaume , Crochet Aurélien , Fromm Katharina M. , Herrmann Andreas 
Published: March 2012

AbstractImidazolidin‐4‐ones are suitable in practical applications as hydrolytically cleavable precursors for the controlled release of fragrant aldehydes and ketones. The corresponding profragrances were prepared by treating aliphatic carbonyl compounds with commercially available amino acid amines in the presence of a base to yield mixtures of diastereomers. The two diastereomers isolated from the reaction of glycinamide hydrochloride with (–)‐menthone were separated by column chromatography. The absolute stereochemistry of the isomers was determined by NMR spectroscopy and confirmed by X‐ray single crystal structure analysis. Under acidic conditions and in protic solvents, the two diastereomers slowly isomerized without releasing the ketone. The hydrolysis of the precursors was investigated by solvent extraction from buffered aqueous solutions and a cationic surfactant emulsion, as well as by dynamic headspace analysis after deposition onto a cotton surface. Generally, ketones were shown to be more readily released than aldehydes. Increasing the size of the substituents at C‐5 decreased the rate of hydrolysis in solution and on the cotton surface. Glycinamide‐based imidazolidin‐4‐ones were more efficient than the corresponding oxazolidin‐4‐ones or oxazolidines. Neither the release rates in solution, nor the hydrophobicity of the precursor structure (which influences deposition), nor the combination of these two parameters allowed easily predicting the performance of the delivery systems in application.
Review of wetting and drying algorithms for numerical tidal flow models
Authors: Medeiros Stephen C. , Hagen Scott C. 
Published: March 2012

SUMMARYA review of wetting and drying (WD) algorithms used by contemporary numerical models based on the shallow water equations is presented. The numerical models reviewed employ WD algorithms that fall into four general frameworks: (1) Specifying a thin film of fluid over the entire domain; (2) checking if an element or node is wet, dry or potentially one of the two, and subsequently adding or removing elements from the computational domain; (3) linearly extrapolating the fluid depth onto a dry element and its nodes from nearby wet elements and computing the velocities; and (4) allowing the water surface to extend below the topographic ground surface. This review presents the benefits and drawbacks in terms of accuracy, robustness, computational efficiency, and conservation properties. The WD algorithms also tend to be highly tailored to the numerical model they serve and therefore difficult to generalize. Furthermore, the lack of temporally and spatially defined validation data has hampered comparisons of the models in terms of their ability to simulate WD over real domains. A short discussion of this topic is included in the conclusion. Copyright © 2012 John Wiley & Sons, Ltd.
DOES ACCESS TO IMPROVED SANITATION REDUCE CHILDHOOD DIARRHEA IN RURAL INDIA?
Authors: Kumar Santosh , Vollmer Sebastian 
Published: March 2012

ABSTRACTAlmost nine million children under 5 years of age die every year. Diarrhea is considered to be the second leading cause of under‐five mortality in developing countries. About one out of five deaths is caused by diarrhea. In this paper, we use the newly available data set District Level Household Survey 3 to quantify the impact of access to improved sanitation on diarrheal morbidity for children less than 5 years of age in India. Using propensity score matching, we find that access to improved sanitation reduces the risk of contracting diarrhea by 2.2 percentage points. There is considerable heterogeneity in the impacts of improved sanitation. We find statistically insignificant treatment effects for children in low or middle socioeconomic status households and for girls; however, boys and children in high socioeconomic status households experienced economically significant treatment effects. The magnitude of the treatment effect differs largely by hygiene behavior. Copyright © 2012 John Wiley & Sons, Ltd.
Molecular characterization of Wilms' tumor from a resource‐constrained region of sub‐Saharan Africa
Authors: Murphy Andrew J. , Axt Jason R. , de Caestecker Christian , Pierce Janene , Correa Hernan , Seeley Erin H. , Caprioli Richard M. , Newton Mark W. , de Caestecker Mark P. , Lovvorn Harold N. 
Published: March 2012

AbstractSub‐Saharan African children have an increased incidence of Wilms' tumor (WT) and experience alarmingly poor outcomes. Although these outcomes are largely due to inadequate therapy, we hypothesized that WT from this region exhibits features of biological aggressiveness that may warrant broader implementation of high‐risk therapeutic protocols. We evaluated 15 Kenyan WT (KWT) for features of aggressive disease (blastemal predominance and Ki67/cellular proliferation) and treatment resistance (anaplasia and p53 immunopositivity). To explore the additional biological features of KWT, we determined the mutational status of the CTNNB1/β‐catenin and WT1 genes and performed immunostaining for markers of Wnt pathway activation (β‐catenin) and nephronic progenitor cell self‐renewal (WT1, CITED1 and SIX2). We characterized the proteome of KWT using imaging mass spectrometry (IMS). The results were compared to histology‐ and age‐matched North American WT (NAWT) controls. For patients with KWT, blastemal predominance was noted in 53.3% and anaplasia in 13%. We detected increased loss to follow‐up (p = 0.028), disease relapse (p = 0.044), mortality (p = 0.001) and nuclear unrest (p = 0.001) in patients with KWT compared to controls. KWT and NAWT showed similar Ki67/cellular proliferation. We detected an increased proportion of epithelial nuclear β‐catenin in KWT (p = 0.013). All 15 KWT specimens were found to harbor wild‐type CTNNB1/β‐catenin, and one contained a WT1 nonsense mutation. WT1 was detected by immunostaining in 100% of KWT, CITED1 in 80% and SIX2 in 80%. IMS revealed a molecular signature unique to KWT that was distinct from NAWT. The African WT specimens appear to express markers of adverse clinical behavior and treatment resistance and may require alternative therapies or implementation of high‐risk treatment protocols.
Selective Excitation of Molecule‐Surface Vibrations in H2 and D2 Dissociatively Adsorbed on Ru(0001)
Authors: Füchsel Gernot , Tremblay Jean Christophe , Klamroth Tillmann , Saalfrank Peter 
Published: March 2012

AbstractIn this contribution we report about the selective vibrational excitation of H2 and D2 on Ru(0001) as an example for nonadiabatic coupling of an open quantum system to a dissipative environment. We investigate the possibility of achieving state‐selective vibrational excitations of H2 and D2 adsorbed on a Ru(0001) surface using picosecond infrared laser pulses. The systems’ behavior is explored using pulses that are rationally designed and others that are optimized using a time‐local variant of Optimal Control Theory. The effects of dissipation on the laser‐driven dynamics are studied using the reduced‐density matrix formalism. The non‐adiabatic couplings between adsorbate and surface are computed perturbatively, for which our recently introduced state‐resolved anharmonic rate model is used. It is shown that mode‐ and state‐selective excitation can be achieved in the absence of dissipation when using optimized laser pulses. The inclusion of dissipation in the model reduces the state selectivity and the population transfer yield to highly excited states. In this case, mode activation is most effectively realized by a rational pulse of carefully chosen duration rather than by a locally optimized pulse.
Modulation of gene expression using electrospun scaffolds with templated architecture
Authors: Karchin A. , Wang Y‐N. , Sanders J. E. 
Published: March 2012

AbstractThe fabrication of biomimetic scaffolds is a critical component to fulfill the promise of functional tissue‐engineered materials. We describe herein a simple technique, based on printed circuit board manufacturing, to produce novel templates for electrospinning scaffolds for tissue‐engineering applications. This technique facilitates fabrication of electrospun scaffolds with templated architecture, which we defined as a scaffold's bulk mechanical properties being driven by its fiber architecture. Electrospun scaffolds with templated architectures were characterized with regard to fiber alignment and mechanical properties. Fast Fourier transform analysis revealed a high degree of fiber alignment along the conducting traces of the templates. Mechanical testing showed that scaffolds demonstrated tunable mechanical properties as a function of templated architecture. Fibroblast‐seeded scaffolds were subjected to a peak strain of 3 or 10% at 0.5 Hz for 1 h. Exposing seeded scaffolds to the low strain magnitude (3%) significantly increased collagen I gene expression compared to the high strain magnitude (10%) in a scaffold architecture‐dependent manner. These experiments indicate that scaffolds with templated architectures can be produced, and modulation of gene expression is possible with templated architectures. This technology holds promise for the long‐term goal of creating tissue‐engineered replacements with the biomechanical and biochemical make‐up of native tissues. © 2012 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 2012.
Cellular attachment and osteoblast differentiation of mesenchymal stem cells on natural cuttlefish bone
Authors: Kim Beom‐Su , Kim Jin Seong , Sung Hark‐Mo , You Hyung‐Keun , Lee Jun 
Published: March 2012

AbstractThe purpose of this study was to describe an approach that aims to provide fundamental information for the application of natural cuttlefish bone. Before applying cuttlefish bone as a bone defect filling material, we evaluated proliferation, adhesion, and cell viability of human mesenchymal stem cells (hMSCs) cultured on cuttlefish bone. Cuttlefish bone was separated into two parts (dorsal shield and lamellar region) and each part was used. Cell proliferation and viability were assessed using the MTS assay and live/dead fluorescence staining method. The morphology was observed using scanning electron microscopy (SEM). hMSCs were stimulated with osteogenic medium and osteoblast differentiation was evaluated. The fluorescence images showed that the seeded cells grew well and that cell distribution was in accordance with the surface morphology of the cuttlefish bone. Compared with the dorsal shield, cells penetrated deeper into the three‐dimensional inner space of the lamellar part. Furthermore, under osteogenic differentiation conditions, alkaline phosphatase activity increased and the mRNA expression of ALP, runt‐related transcription factor 2, and collagen type I α1 was increased in hMSCs cultured on both the dorsal shield and lamellar block. These results indicate the potential of cuttlefish bone as an ideal scaffold for bone regenerative materials. © 2012 Wiley Periodicals, Inc. J Biomed Mater Res Part A, 2012.
Novel protein pp3501 mediates the inhibitory effect of sodium butyrate on SH‐SY5Y cell proliferation
Authors: Wang Yajun , Ma Chao , Zhang Haitao , Wu Jun 
Published: March 2012

AbstractSodium butyrate, a new potential therapeutic drug, improves the efficacy of chemo‐ and immunotherapy of cancer under unknown mechanisms. A novel gene pp3501 is significantly induced in SH‐SY5Y neuroblastoma cells upon sodium butyrate treatment. Therefore, this study has cloned pp3501 cDNA by RT‐PCR and generated its recombinant fusion protein and anti‐serum subsequently. The pp3501 protein localized mainly in the nucleus, as detected by immunocytochemistry and the expression of pp3501‐EGFP fusion protein. pp3501 inhibited the proliferation of SH‐SY5Y cells, arrested the cell cycle at G1 phase, and sensitized the SH‐SY5Y cells to sodium butyrate treatment. These results provide a new mechanism of sodium butyrate inhibiting cancer cell proliferation as well as a new avenue for the future research on the functions of pp3501. J. Cell. Biochem. 113: 2696–2703, 2012. © 2012 Wiley Periodicals, Inc.
The application of genomic and molecular data in the treatment of chronic cancer pain
Authors: Turabi Ali , Plunkett Anthony R. 
Published: March 2012

AbstractMany cancer patients will develop complex pain syndromes requiring aggressive, innovative, and comprehensive multimodal pain management strategies. Recently, data from both animal studies and clinical trials have allowed clinical research to focus on creating applicable clinical treatment strategies. This article is a review of genomic and molecular data, which has contributed to creating novel modalities for use in clinical pain management of patients with cancer‐induced pain. J. Surg. Oncol. 2012; 105:494–501. © 2012 Wiley Periodicals, Inc.
Translational advances in pain and anesthesia for cancer patients
Authors: Maani Christopher V. , Shah Mohammad A. , Hansen Jacob J. , Fowler Marcie , Maani Elizabeth V. , McGhee Laura L. 
Published: March 2012

AbstractEffective cancer pain management requires multidisciplinary approaches for multimodal analgesia. Although opioids have been the cornerstone, developments such as regional anesthesia and interventional pain techniques, complementary and alternative medicine, and new pharmaceuticals also have shown promise to relieve cancer pain. This overview of relevant clinical efforts and the modern day state of the science will afford a better understanding of pain mechanisms and multimodal approaches beneficial in optimizing analgesia for cancer patients. J. Surg. Oncol. 2012; 105:488–493. © 2012 Wiley Periodicals, Inc.
Translational advances regarding hereditary breast cancer syndromes
Authors: Gage M. , Wattendorf D. , Henry L.R. 
Published: March 2012

AbstractApproximately 5–10% of breast cancers may be inheritable, up to 90% of which are due to mutations in BRCA1 and BRCA2. A substantial minority are caused by non‐BRCA mutations, such as TP53, PTEN, STK11, CHEK2, ATM, BRIP1, and PALB2 mutations. This review highlights translational research advances with regard to the development of probabilistic models for hereditary breast cancer syndromes, the identification of specific genetic mutations responsible for these syndromes, as well as their testing and interpretations. J. Surg. Oncol. 2012; 105:444–451. © 2012 Wiley Periodicals, Inc.