bluuebunny/crossref_metadata_2025_split huggingface dataset:
The complex regulation of Slo1 potassium channels from a structural perspective
Authors: Raisch Tobias 
Published: May 2024

Abstract
Fast and regulated potassium efflux by Slo1 channels is crucial in many tissues in animals including neurons, the kidney and smooth muscle. During the last decade, structures have revealed many details about the gating mechanism and regulation of these large and complex molecular machines. This review summarizes these findings and the current knowledge about the intricate regulation of these important channels. Slo1 integrates sensing of the membrane potential via a voltage-sensor domain that undergoes subtle but significant structural rearrangements with a calcium-induced expansion of parts of the intracellular gating ring. Together, these two signals synergistically lead to changes in the conformation and chemical nature of the pore domain, allowing potassium ions to be translocated. In many native tissues, Slo1 channels are assembled with at least three classes of auxiliary subunits that change the gating kinetics or allow the channel to open also in absence of one of the two signals. Finally, Slo1 is inhibited, activated or deregulated by natural toxins and synthetic compounds, underlining the importance of the channel for the organism and as a potential target for drugs and other molecules.
On the relationship between complexity of primary occupation and L2 varietal behavior in adult migrants in Austria
Authors: Wirtz Mason A. 
Published: May 2024

Abstract
This article explores for the first time the relationship between occupational complexity (operationalized using the complexity measures indicated in the Dictionary of occupational titles) and adult migrants’ second language (L2) sociolinguistic repertoires in the Austro-Bavarian naturalistic context. We analyze the data of 36 adult migrant L2 German speakers who participated in a virtual reality experiment involving interactions with a dialect-speaking and standard German-speaking interlocutor, the goal being to capture participants’ interpersonal varietal behavior, that is, their addressee-relational, differential use of standard German, Austro-Bavarian dialect, and mixture varieties. Bayesian multinomial mixed-effects models reveal that participants with occupations requiring more handling and physical precision work are predicted to employ dialect varieties more often, but exclusively in interaction with the standard German-speaking interlocutor. A person-centered visual-quantitative analysis additionally facilitates insights concerning which migrants deviate most notably from group-level patterns, and how these deviations may relate to the complexity of their primary occupation. More generally, this study paves new ground with respect to how we can operationally define and capture the complexity of occupational status, and moreover sets out a new direction for research questions investigating how career-related differences impact on (L2) language variation and use.
Synthesis, characterization, thermal, theoretical studies, antimicrobial, antioxidant activity, superoxide dismutase-like activity and catalase mimetics of metal(II) complexes derived from sugar and Schiff base
Authors: Bufarwa Saleh , El-Seifat Reem , Binhamad Hana , Hesien Rehab 
Published: May 2024

Abstract
Scientists are searching for reactive oxygen species, which have been associated with various health issues like heart problems, neurological disorders, inflammation, and aging. Salen complexes have proven to be effective in multiple oxidative stress situations and have been used as catalase and superoxide mimetics. To explore this further, three mixed complexes were synthesized using a Schiff base (salen) and a sugar (d-glucose) with Co(II), Ni(II), and Cu(II) ions. These complexes were then diagnosed by different analytical and spectral techniques. Stoichiometry, stereochemistry, some physical properties, and the method of bonding complexes were measured. Comparisons of the IR and 1HNMR spectra of the ligands with the complexes demonstrated the involvement of the azomethine group of the ligand in the chelation process. The mass spectra and TGA agree with the proposed formula of the complexes, and the conductivity and UV–Vis data supported the octahedral geometry of the complexes, and information was obtained from partial parameter calculations by molecular modeling. The metal complexes exhibited strong antimicrobial and antioxidant properties when compared to standard drugs. The like-superoxide and catalyst mimetic complexes were screened using DPPH ABTS, revealing their effectiveness.
Magnetoacoustic waves in spin-1/2 dense quantum degenerate plasma: nonlinear dynamics and dissipative effects
Authors: Abd-Elzaher Mohamed , Nisar Kottakkaran S. , Abdel-Aty Abdel-Haleem , Karmakar Pralay K. , Atteya Ahmed 
Published: May 2024

Abstract
Within the confines of a two-fluid quantum magnetohydrodynamic model, the investigation of magnetoacoustic shock and solitary waves is conducted in an electron-ion magnetoplasma that considers electrons of spin 1/2. When the plasma system is nonlinearly investigated using the reductive perturbation approach, the Korteweg de Vries-Burgers (KdVB) equation is produced. Sagdeev’s potential is created, revealing the presence of solitary solutions. However, when dissipative terms are included, intriguing physical solutions can be obtained. The KdVB equation is further investigated using the phase plane theory of a planar dynamical system to demonstrate the existence of periodic and solitary wave solutions. Predicting several classes of traveling wave solutions is advantageous due to various phase orbits, which manifest as soliton-shock waves, and oscillatory shock waves. The presence of a magnetic field, the density of electrons and ions, and the kinematic viscosity significantly alter the properties of magnetoacoustic solitary and shock waves. Additionally, electric fields have been identified. The outcomes obtained here can be applied to studying the nature of magnetoacoustic waves that are observed in compact astrophysical environments, where the influence of quantum spin phenomena remains significant, and also in controlled laboratory plasma experiments.
The effect of pre-painting and W-temper forming on springback
Authors: Dessie Jemal Ebrahim , Lukacs Zsolt 
Published: May 2024

AbstractThe present investigation examined the impact of thermal cycling applied during the painting of sheet steels and the transfer period in the forming of W-temper heat treatment of high-strength aluminum alloy on springback. The U-draw bending test was conducted numerically and experimentally to examine the springback parameters. Pre-painted steel might be aged due to surface cycling during painting and it changes the mechanical characteristics. As a result, pre-painted steel becomes more susceptible to springback. It is also observed that springback is mostly reliant on the amount of transfer time between the W-temper forming of aluminum alloy. To sum up, the interplay among material characteristics, processing techniques, and forming conditions leads to the springback phenomena.
Aplicación del principio de progresividad y no regresividad de los derechos económicos, sociales y culturales frente a otros principios (matriz principios)
Authors: Calvo Chaves Néstor Javier 
Published: May 2024

La aplicación realizada por la jurisprudencia constitucional colombiana del principio de progresividad y no regresividad de los derechos económicos, sociales y culturales permite evidenciar cómo su significado y alcance se ha integrado con otros principios en cuanto a la imposición de obligaciones al Estado, la interpretación de los contenidos constitucionales y la efectividad de los derechos constitucionales. Este escrito recoge, a partir de la Matriz Principios, la aplicación del referido principio en las categorías: Principio del Estado Social de Derecho, criterio de sostenibilidad fiscal, principios de accesibilidad y calidad, principio de continuidad, principio de igualdad, principio de favorabilidad y principio de seguridad jurídica.
ALTAS HABILIDADES/SUPERDOTAÇÃO: O ATENDIMENTO EDUCACIONAL NA PERSPECTIVA DE PROFISSIONAIS TÉCNICOS EM EDUCAÇÃO ESPECIAL NA CIDADE DE CORUMBÁ/MS
Authors: Silva Jaciane Soares , Martins Bárbara Amaral 
Published: May 2024

A literatura especializada aponta que alunos com altas habilidades/superdotação (AH/SD) tendem a ser negligenciados em sala de aula, pois o senso comum leva a acreditar que não precisam de atenção diferenciada, porque podem se desenvolver sozinhos, o que muitas vezes faz com que aconteça o contrário, isto é, o não desenvolvimento de seus potenciais. Dessa forma, esses estudantes acabam perdendo seus talentos por falta de estímulo e um atendimento adequado. Assim, este artigo visa investigar o atendimento de alunos com AH/SD nas escolas da rede municipal de Corumbá no estado de Mato Grosso do Sul. Consequentemente, esta pesquisa tem como objetivos específicos: analisar se as escolas oferecem o Atendimento Educacional Especializado (AEE) para estudantes com AH/SD; verificar quem são os alunos com AH/SD indicados para o AEE; analisar as concepções de profissionais técnicas em Educação Especial sobre o atendimento aos alunos com AH/SD. Com base na realização de entrevistas semi-estruturadas junto a três profissionais, conclui-se que as escolas municipais de Corumbá não estão preparadas para atender os alunos com AH/SD, pois carecem de mais salas de AEE, profissionais qualificados e suficientes para atender a demanda da Educação Especial, especialmente no que se refere aos alunos com AH/SD. Por fim, a falta de informação e de formação dos profissionais que atuam no ensino comum dificulta a identificação e o atendimento desses discentes.
Podcast como ferramenta para acesso à informação sobre saúde, alimentação e nutrição na infância
Authors: Veiga Santos Thaiane , De Jesus Souza Maria Carla , Macedo Almeida Camilo Valéria , Da Mota Santana Jerusa 
Published: May 2024

O objetivo deste estudo é relatar a experiência do projeto Papo Seguro: diálogos sobre alimentação, nutrição e saúde na infância, no âmbito da Atenção Primária à Saúde. Trata-se de um estudo descritivo, na modalidade de relato de experiência, desenvolvido entre março e dezembro de 2022, envolvendo Agentes Comunitários de Saúde, pais e cuidadores de crianças até a fase escolar, de duas Unidades de Saúde da Família no Município de Santo Antônio de Jesus-BA. Foram construídos e divulgados doze episódios, com temas relacionados às quatro fases da vida da criança: amamentação; alimentação complementar; alimentação do pré-escolar e alimentação do escolar. Após a divulgação dos episódios, houveram retornos dos ouvintes, os mesmos demonstraram que os conteúdos foram compreendidos, reforçaram a importância das abordagens e sugeriram continuidade dos podcasts. Conclui-se que o uso do podcast na promoção da Educação Alimentar e Nutricional, sobretudo sobre a alimentação infantil, é eficaz na propagação de informações baseada na ciência, na Atenção Básica à Saúde. Além disso, permitiu aos discentes e pesquisadores uma nova forma de se fazer saúde e a disseminação de uma tecnologia digital para a promoção da saúde no SUS.

Palavras-chave: Webcast; Comunicação; Nutrição da criança; Educação alimentar e nutricional.
IRMÃS CATEQUISTAS FRANCISCANAS EM ITAPORÃ (1964-1983):
Authors: Janczeski Vanessa Zanquini , Bezerra Giovani Ferreira 
Published: May 2024

O objetivo do artigo é abordar a presença e atuação missionária das Irmãs Catequistas Franciscanas (1964-1983) na zona rural de Itaporã, antigo sul de Mato Grosso (até 1977)/Mato Grosso do Sul (depois de 1977), mais precisamente na escola rural mista inicialmente denominada como “Escola de São Francisco” (1955-1974), e, por fim, como “Escola Francisco de Assis” (1974-2003). Adota-se a perspectiva teórico-metodológica da História Cultural e da História Oral temática. Recorreu-se a diversas fontes, como: documentação escrita da e sobre a escola, depoimentos orais de ex-alunos e/ou ex-professores da escola, correspondências trocadas com as religiosas e livros de memorialistas. Os resultados indicam que as religiosas representavam confiança para as famílias dos estudantes, pois, naquela época, a maioria das pessoas que residia na região se declarava católica e, para elas, tendo pessoas da mesma religiosidade no comando dos estudos, era considerado privilégio, pois, comumente, os professores de escolas rurais eram leigos. A educação e a religião estiveram, assim, aliadas. As religiosas estabeleciam relações de respeito com a população por meio de suas ações catequéticas e pedagógicas na região. A sala de aula era vista como um processo civilizatório dotados de valores cristãos em busca de uma sociedade exemplar, segundo a moral cristã.
New Perspectives of Embryo Sexing Through Morphological Criteria and Sperm Fertilizing Parameters in Mammalian Species: A Review
Authors: Mohammed A.A. , AlGherair I. , Al-Suwaiegh S. , Alshaibani N. , Alsenayin F. , Alsaleem R. , Alsaif M. , Alsayed B. , Alsfran A. , Alarfaj K. , Alghafli Z. , Mohammed A. , Mohammed A. 
Published: May 2024

Predetermining embryo sexing before the time of conception could be controlled before fertilization of the oocyte or detected after fertilization. These methods are expensive, time-consuming and negatively affect the development of embryos. The methods used for embryo sexing are based on sperm separation before fertilizing the oocyte or molecular basis of nuclear or mitochondrial DNA. The selection of spermatozoon fertilizing controls the sex of the zygote in vivo or in vitro matured oocytes. In addition, the detection of embryo sexing is determined through aspiration of one cell from the eight-cell stage embryo and investigated through PCR. The oocyte fertilization by a spermatozoon bearing a Y-chromosome gives male offspring, although that fertilized by a spermatozoon bearing an X-chromosome gives female offspring. The embryonic cell aspiration negatively affected the further developmental competence of embryos. Therefore, establishing a new method for embryo sexing in mammals through measurable morphological criteria (zona pellucida, homogeneity of cytoplasm, previtelline space and stage of development) is a great boon in animals and humans. The success in embryo sexing through morphological criteria maximizes the advantages of assisted reproductive techniques. Therefore, the present review article addresses and discusses the preselection of embryo sexing at the time of conception and their limitation and effects in addition to sperm fertilizing parameters on mammals.
Detection and Classification of Wilting in Soybean Crop using Cutting-edge Deep Learning Techniques
Authors: Na Myung Hwan , Na In Seop 
Published: May 2024

Background: This paper employs deep learning in the classification of soybean wilting, a plant health indicator affected by external pressures, using a Convolutional Neural Network (CNN) with a pre-trained model. It highlights the promise of deep learning in agriculture by examining the relevance of wilting, evolution in the agricultural sector and applications in crop wellness monitoring. Methods: A CNN is used in the study to classify soybean withering, with special attention to the VGG16 pre-trained model. Deep learning’s ability to interpret complex data patterns is harnessed for intelligent and accurate wilting detection. A smart detection system tailored for soybean wilting is developed, incorporating recent advancements and addressing associated challenges. Result: The CNN model, notably VGG16, achieves 76% overall accuracy in distinguishing healthy and wilted soybean leaves, signifying a transformative shift in soybean crop health management. The approach offers a precise, efficient and sustainable solution supported by state-of-the-art CNN technology, advancing soybean cultivation practices.
Revolutionizing Education: Empowering Disaster Preparedness through Innovative Smart Teaching with e-Modules on FlipCreator Pro Platform
Authors: Syarif Erman , Malik Abdul , Saputro Alief , Hasriyanti Hasriyanti 
Published: May 2024

Technology plays an important role to facilitate digital learning including to enhance students’ disaster preparedness. Therefore, teachers must be creative particularly for their course design. This study aims to develop smart teaching using e-modules with the FlipCreator Pro platform. We used Research and Development (R&D) with ADDIE model to develop e-modules involving experts and teachers to determine the validation of product. In additon, we measured students’ response towards quality of e-modules. Results show that developed e-moduls was adequate to validities, therefore it can be used to collected further data. The module's user-friendly design and practicality make it accessible and beneficial for students, promising improved comprehension and learning outcomes. Future research suggestions include expanding content, adapting for various grades, integrating AI, and conducting wider trials for generalizability. Examining the impact on student learning and teacher involvement is recommended for further exploration.
Taxonomy of purposes, principles, forms, technologies in on-line education: comparative analysis of virtual universities: pedagogical aspects
Authors: Alisov E. А. , Podymova L. S. , Makarova L. N. 
Published: May 2024

Importance. The paper presents the findings of comparative pedagogical research done against the backdrop of new tendencies and developments on the global learning landscape. With the pandemic pushing universities online and ensuing digitalization of educational environment with a flurry of multi aspect virtual learning activities, there has emerged a growing need for reliable criteria to assess effectiveness and efficiency in higher education. The research is aimed to build the taxonomy of virtual universities purposes with the focus on the paramount principles, educational forms and technologies they employ.Research Methods. The research methods involved comparative, descriptive, inductive-deductive ones, typical of comparative pedagogy. We studied the purposes, principles, forms and technologies used by the following virtual universities: The UK’s Open University), Canadian Virtual University (CVU), The University of Phoenix (UoP), The Virtual University for Small States of The Commonwealth (VUSSC), The Virtual University of Pakistan.Results and Discussion. The research enabled us to aggregate, analyze and compartmentalize the data on purposes, principles, forms and technologies of different virtual universities, which offers a new viewpoint on i-learning in a new setting. The purposes of virtual universities are presented in the hierarchical order in compliance with the goal-setting levels: expediency, focus (purposes on this level are differentiated according to the type of activity: educational, pedagogical, maintaining and organizational) and goal commitment. We identified a set of basic principles regulating academic activity of virtual universities in the digitalization context of education, described the most popular forms and technologies employed and specified priority activities of virtual universities.Conclusion. The taxonomy of purposes and paramount principles of virtual universities educational activities make these activities unique. The number of factors and variables defining the educational activities of virtual universities is growing, still the ability to choose the learning route which fits a certain individual has always been and will remain important. Tailored learning style (built on individual preferences in the ways of information searching and processing) suggests an opportunity to adjust the situation and learning material to your needs and thus become more efficient in obtaining new information and skills.
Technology for organizing self-regulated learning at the stage of early professionalization of high school students in psychological and pedagogical classes
Authors: Garashkina N. V. , Druzhinina A. A. 
Published: May 2024

Importance. In the modern world, the role of the teacher has changed, and now students – future teachers are faced with the task of not only teaching, but also being prepared for constant self-development, professional growth and continuous learning. Modern regulatory documents of the teacher education system define competence that promotes self-education as necessary for mastery by a future teacher. Developing the ability for self-regulation in students in the pedagogical education system has great potential for successful professional development. Therefore, it is important to organize an effective process of self-regulated learning in a modern school at the stage of early professionalization in psychological and pedagogical classes. The purpose of the study is to develop and substantiate a technology for organizing self-regulated learning that promotes successful readiness for personal and professional development of high school students – students of psychological and pedagogical classes.Research Methods. Analysis of data from theoretical and empirical research in the field of self-regulated learning, also used: analysis, synthesis, generalization, comparison and interpretation, survey.Results and Discussion. Self-regulated learning is a process in which students actively participate in their own learning activities. High school students involved in self-regulated learning show higher educational results, quickly master course materials and more often achieve their personal goals. In the context of the cognitive-technological approach to learning, an innovative technology of self-regulated learning at the stage of early professionalization of high school students in specialized psychological and pedagogical classes is scientifically substantiated, including an activity algorithm: self-diagnosis – goal setting – self-motivation – planning – implementation of personal strategy – self-reflection; as well as diagnostic and autodidactic methods. A diagnostic technique has been developed to identify the level of students’ readiness for self-regulated learning.Conclusion. Considering that self-regulated learning is a complex process that requires many years of practice, training and experience, its effective use in the format of technology for organizing self-regulated learning, especially at the stage of early professionalization in psychological and pedagogical classes. The effect is enhanced when using a cognitive-technological approach, an algorithm of stages and a set of auto-didactics methods. The designed technology is a valuable innovative tool for increasing the efficiency of psychological and pedagogical classes, as well as for research and practice in the field of teacher education.