bluuebunny/crossref_metadata_2025_split huggingface dataset:
Toward new insights on the white blood cell differential by flow cytometry: A proof of concept study on the sepsis model
Authors: Roussel Mikael , Gros Antoine , Gacouin Arnaud , Le Meur Nolwenn , Le Tulzo Yves , Fest Thierry 
Published: April 2012

AbstractBackground:We sought to evaluate, on a model of sepsis, the clinical relevance of new parameters obtained on a white blood cell (WBC) differential by flow cytometry, implemented in the routine workflow of our hematology laboratory.Methods:A WBC with differential by flow cytometry was done on 459 patients at admission in intensive care unit. They were retrospectively categorized in having (i) infection or not or (ii) a high gravity score (severe sepsis or septic shock) or not. We analyzed by hierarchical clustering, in a multidimensional manner, 50 parameters provided by the flow cytometric platform in place of the standard seven parameters for a standard differential.Results:Our approach allows to discriminate on the basis of a WBC differential (i) infected patients at admission based on a 16 parameter signature, with a concordance rate of 72.7% and a specificity of 79.9% and (ii) patients with high gravity score (septic shock or severe sepsis) at admission with a signature of eight parameters, with a concordance rate of 74.7% and a specificity of 75.9%.Conclusions:This study shows the clinical relevance of an extended WBC differential to obtain by a flow cytometer integrated into a routine hematology laboratory workflow. Development of such approach implicates the redefinition of the WBC differential by integrating new parameters. © 2012 International Clinical Cytometry Society
Performance of transmitted reference pulse cluster ultra‐wideband systems with forward error correction
Authors: Liang Zhonghua , Dong Xiaodai , Aaron Gulliver T. , Liao Xuewen 
Published: April 2012

SUMMARYRecently, an improved transmitted reference (TR) signaling scheme, referred to as transmitted reference pulse cluster (TRPC), was proposed for low‐rate ultra‐wideband (UWB) communications. Compared with conventional TR, TRPC has a more compact and uniform spacing for the reference and data pulses and therefore addresses the implementation problems posed by the long delay line requirement, as well as provides better bit error rate (BER) performance. In this paper, a TRPC‐UWB system, which includes practical forward error correction (FEC) coding such as that specified in the IEEE 802.15.4a standard, as well as more powerful convolutional codes, is developed. A performance analysis, which highlights the importance of selecting appropriate FEC codes, is presented. Results show that with a suitable FEC code, the TRPC‐UWB system is a promising candidate for low‐rate wireless personal area networks. Copyright © 2012 John Wiley & Sons, Ltd.
Anti‐Inflammatory and Antiproliferative Activities of Organic Fractions from the Mediterranean Brown Seaweed, Cystoseira Compressa
Authors: Mhadhebi Lamia , Dellai Afef , Clary‐Laroche Audrey , Said Rafik Ben , Robert Jacques , Bouraoui Abderrahman 
Published: April 2012

Abstract

Strategy, Management and Health Policy

Enabling Technology, Genomics, Proteomics
Preclinical Research
Preclinical Development Toxicology, Formulation Drug Delivery, Pharmacokinetics
Clinical Development Phases I‐III Regulatory, Quality, Manufacturing
Postmarketing Phase IV

The inability to cure many diseases, such as cancer and arthritis, has stimulated the need for the development of new drugs from natural sources. Of all natural sources, the marine environment is clearly the last great frontier for pharmaceutical and medical research. As part of our search for new anti‐inflammatory or anticancer potential drugs, organic fractions (chloroform, ethyl acetate and methanol) from the Mediterranean brown seaweed, Cystoseira compressa were evaluated for in vivo anti‐inflammatory activity, using the carrageenan‐induced rat paw edema model and in vitro antiproliferative effect in three human cancer cell lines (A549, lung cell carcinoma; HCT15, colon cell carcinoma; and MCF7, breast adenocarcinoma), using an MTT assay. The chloroform and ethyl acetate fractions exhibited dose‐dependent anti‐inflammatory activity, comparable with the reference drug acetylsalicylic–lysine (300 mg/kg; i.p.). The percent inhibition of edema, 3 h after carrageenan injection ranged from 63 to 76% and 65 to 78%, respectively. The organic fractions (F‐CHCl3, F‐EtOAC, and F‐MeOH) also exhibited antiproliferative activity against the three human cancer cell lines with IC50 values ranging from 78–82 μg/ml; 27–50 μg/ml and 110–130 μg/ml; respectively. Thus, the chloroform and ethyl acetate fractions of C. compressa evidenced an interesting anti‐inflammatory activity associated with significant antiproliferative activity, efficacies that correlated with their total phenol content. The purification and the determination of chemical structures of compounds of these active fractions are under investigation.
Scanning thin‐sheet laser imaging microscopy elucidates details on mouse ear development
Authors: Kopecky Benjamin , Johnson Shane , Schmitz Heather , Santi Peter , Fritzsch Bernd 
Published: April 2012

AbstractThree‐dimensional development of a mouse inner ear from embryonic day 11.5 (top left) to postnatal day 15 (bottom right) using Thin‐Sheet Laser Imaging Microscopy followed by segmentation provides an added dimension to inner ear analysis. From Kopecky et al., Developmental Dynamics 241:465–480, 2012.
Understanding wetland plant dynamics in response to water table changes through ecohydrological modelling
Authors: Palanisamy Bakkiyalakshmi , Chui Ting Fong May 
Published: April 2012

ABSTRACTVulnerability of wetland vegetation to water table changes is a widely studied topic in the field of ecology. Extreme flood or drought conditions imposed on wetlands cause disappearance of plants or shift in the vegetation regime. The recovery of such plant compositions is of particular importance when the wetland is subjected to frequent water table fluctuations resulting from land use changes and requires knowledge of mechanisms underlying evolution of plant growth to changing hydrologic conditions. We used a spatially varying, coupled groundwater–vegetation growth model to investigate the survival mechanism of wetland herbaceous plants. The plants were subjected to long‐term water table drainage because of land use changes that caused the disappearance of one of the species composition. In an effort to revive the disappeared species, hypothetical soil saturation was introduced onto the study domain through elevated water table level. Even though the system had returned to hydrologically favourable environment, the disappeared species was unable to recover, which in turn led to the evaluation of factors that determine the re‐emergence of the species through sensitivity analysis. The results of the sensitivity analysis showed that the disappeared species recovered during scenarios of reduced duration of drawdown, increased assimilation rates and increased competitiveness. The analysis also showed that the competitiveness of the plants, which was modelled by the classic Lotka–Volterra algorithm, supersedes any of the unfavourable plant growth characteristics. The results of this study demonstrated the ability of the groundwater–vegetation response model to facilitate an understanding of plant development and a hierarchy of important factors that promote their growth in altered hydrologic conditions. Copyright © 2012 John Wiley & Sons, Ltd.
Spherical tokamak generation and merging on UTST using ex‐vessel poloidal field coils only
Authors: Imazawa Ryota , Kamio Shuji , Hihara Ryuma , Abe Keita , Sakamura Morio , Cao Qinghong , Yamada Takuma , Inomoto Michiaki , Takase Yuichi , Ono Yasushi 
Published: April 2012

AbstractWe successfully generated two spherical tokamaks (ST) at two null points by using ex‐vessel poloidal field (PF) coils only and succeeded in merging them. This scheme is called a double null merging (DNM) scheme. First, two pairs of ex‐vessel PF coils generate two null points where the poloidal field is zero at the upper and lower regions inside the vacuum vessel. Then a poloidal flux swing generates two STs at two null points, because the distance to the wall along the magnetic field is long at the null points. Finally, the coil currents push two STs toward the mid‐plane and merge them into a single ST. Since a magnetic reconnection during merging transforms magnetic energy into thermal energy, this merged ST plasma is expected to have a high beta. It must be noted that the DNM scheme generates an ST without a center solenoid coil. The DNM scheme was demonstrated on the TS‐3/4 (Japan) and MAST (UKAEA). However, these devices have all PF coils inside the vacuum vessels, and the initial plasmas were generated around the PF coils, not the null points. Since internal coils are not feasible in a fusion reactor due to high neutron flux, it is important to demonstrate the DNM scheme by using ex‐vessel PF coils. © 2012 Wiley Periodicals, Inc. Electr Eng Jpn, 179(4): 18–24, 2012; Published online in Wiley Online Library (wileyonlinelibrary.com). DOI 10.1002/eej.21254
Lanthanide Loaded Zeolites, Clays, and Mesoporous Silica Materials as MRI Probes New Bisaqua Picolinate‐Based Gadolinium Complexes as MRI Contrast Agents with Substantial High‐Field Relaxivities Supramolecular Adducts of Negatively Charged Lanthanide(III) DOTP Chelates and Cyclodextrins Functionalized with Ammonium Groups: Mass Spectrometry and Nuclear Magnetic Resonance Studies (Eur. J. Inorg. Chem. 12/2012)
Authors: Peters Joop A. , Mazzanti Marinella , Geraldes Carlos F. G. C. , Pierre Valérie C. 
Published: April 2012

AbstractThe front cover picture shows gives an impression on the breadth of coverage of this Cluster Issue on Metal‐Based Magnetic Resonance Imaging Probes. Superimposed on an angiographic MRI image are the zeolite cages for Gd3+ and the mode of action of this probe from the review by J. A. Peters and K. Djanashvili (top) and a depiction of the principle of magnetoluminescent contrast agents for dual MRI and luminescence imaging (V. C. Pierre et al., bottom right). Representative of papers on different approaches to optimize the efficacy of contrast agents are the PARACEST properties of the large Tm‐DOTP–cyclodextrin complex of C. F. G. C. Geraldes et al. (bottom left) and the high relaxivity associated with two bis(aqua) complexes of M. Mazzanti et al. (center left). We thank the authors for making their graphics available for use on the cover and Dr. Giorgio Gatti for the time‐consuming creation of this attractive picture. magnified image
Seismic capacity of irregular unreinforced masonry walls with openings
Authors: Parisi Fulvio , Augenti Nicola 
Published: April 2012

SUMMARYMasonry buildings are often characterized by geometric irregularities. In many cases, such buildings meet global regularity requirements provided by seismic codes, but they are composed by irregular walls with openings. The latter are masonry walls characterized by (i) openings of different sizes, (ii) openings misaligned in the horizontal and/or vertical direction, or (iii) a variable number of openings per story. An irregular layout of openings can induce not only a nonuniform distribution of gravity loads among masonry piers but also unfavorable damage localizations resulting in a premature collapse of the wall and hence a higher seismic vulnerability.This paper is aimed at providing a simplified methodology to assess the effects of irregularities on the in‐plane seismic capacity of unreinforced masonry (URM) walls with openings. To this end, a macroelement method was developed and validated through experimental results available in the literature.The proposed methodology was based on the quantification of wall irregularities by means of geometric indices and their effects on seismic capacity of URM walls with openings through both sensitivity and regression analyses. Sensitivity analysis was based on a high number of static pushover analyses and allowed to assess variations in key seismic capacity parameters. Regression analysis let to describe each capacity parameter under varying irregularity index, providing empirical models for seismic assessment of irregular URM walls with openings. The in‐plane seismic capacity was found to be significantly affected by wall irregularities, especially in the case of openings with different heights. Copyright © 2012 John Wiley & Sons, Ltd.
Seismic assessment of concrete gravity dams using capacity estimation and damage indexes
Authors: Alembagheri Mohammad , Ghaemian Mohsen 
Published: April 2012

SUMMARYA new concept to determine state of the damage in concrete gravity dams is introduced. The Pine Flat concrete gravity dam has been selected for the purpose of the analysis and its structural capacity, assuming no sliding plane and rigid foundation, has been estimated using the two well‐known methods: nonlinear static pushover (SPO) and incremental dynamic analysis (IDA). With the use of these two methods, performance and various limit states of the dam have been determined, and three damage indexes have been proposed on the basis of the comparison of seismic demands and the dam's capacity. It is concluded that the SPO and IDA can be effectively used to develop indexes for seismic performance evaluation and damage assessment of concrete gravity dams. Copyright © 2012 John Wiley & Sons, Ltd.
Subclinical Bulimia Predicts Conduct Disorder in Middle Adolescent Girls
Authors: Viinamäki Anni , Marttunen Mauri , Fröjd Sari , Ruuska Jaana , Kaltiala‐Heino Riittakerttu 
Published: April 2012

AbstractThis study investigates the comorbidity and longitudinal associations between self‐reported conduct disorder and subclinical bulimia in a community‐based sample of Finnish adolescents in a 2‐year prospective follow‐up study. There are 2070 adolescents who participated in the survey as ninth graders (mean age 15.5) and followed‐up 2 years later. The Youth Self‐Report Externalizing scale was used to measure conduct disorder and DSM‐IV‐based questionnaire to measure bulimia. Co‐occurrence of female conduct disorder and subclinical bulimia was found at ages 15 and 17. Subclinical bulimia among girls at age 15 was a risk factor for conduct disorder at age 17, but conduct disorder at age 15 was not predictive of subclinical bulimia at age 17. The pathway from bulimia to conduct disorder may be suggestive of an association with future borderline personality disorder among girls. Copyright © 2012 John Wiley & Sons, Ltd and Eating Disorders Association.
A Two‐Platform Design for Next Generation Genome‐Wide Association Studies
Authors: Sampson Joshua N. , Jacobs Kevin , Wang Zhaoming , Yeager Meredith , Chanock Stephen , Chatterjee Nilanjan 
Published: April 2012

AbstractGenome‐wide association studies (GWAS) have been successful in their search for common genetic variants associated with complex traits and diseases. With new advances in array technologies together with available genetic reference sets, the next generation of GWAS will extend the search for associations with uncommon SNPs (1% ⩽ MAF ⩽ 10%). Two possible approaches are genotyping all participants, a prohibitively expensive option for large GWAS, or using a combination of genotyping and imputation. Here, we consider a two platform method that genotypes all participants on a standard genotyping array, designed to identify common variants, and then supplements that data by genotyping only a small proportion of the participants on a platform that has higher coverage for uncommon SNPs. This subset of the study population is then included as part of the imputation reference set. To demonstrate the use of this two‐platform design, we evaluate its potential efficiency using a newly available dataset containing 756 individuals genotyped on both the Illumina Human OmniExpress and Omni2.5 Quad. Although genotyping all individuals on the denser array would be ideal, we find that genotyping only 100 individuals on this array, in combination with imputation, leads to only a modest loss of power for detecting associations. However, the loss of power due to imputation can be more substantial if the relative risks for rare variants are significantly larger than those previously observed for common variants. Genet. Epidemiol. 36:400–408, 2012. © 2012 Wiley Periodicals, Inc.
Linear and curvilinear correlations of brain gray matter volume and density with age using voxel‐based morphometry with the Akaike information criterion in 291 healthy children
Authors: Taki Yasuyuki , Hashizume Hiroshi , Thyreau Benjamin , Sassa Yuko , Takeuchi Hikaru , Wu Kai , Kotozaki Yuka , Nouchi Rui , Asano Michiko , Asano Kohei , Fukuda Hiroshi , Kawashima Ryuta 
Published: April 2012

AbstractWe examined linear and curvilinear correlations of gray matter volume and density in cortical and subcortical gray matter with age using magnetic resonance images (MRI) in a large number of healthy children. We applied voxel‐based morphometry (VBM) and region‐of‐interest (ROI) analyses with the Akaike information criterion (AIC), which was used to determine the best‐fit model by selecting which predictor terms should be included. We collected data on brain structural MRI in 291 healthy children aged 5–18 years. Structural MRI data were segmented and normalized using a custom template by applying the diffeomorphic anatomical registration using exponentiated lie algebra (DARTEL) procedure. Next, we analyzed the correlations of gray matter volume and density with age in VBM with AIC by estimating linear, quadratic, and cubic polynomial functions. Several regions such as the prefrontal cortex, the precentral gyrus, and cerebellum showed significant linear or curvilinear correlations between gray matter volume and age on an increasing trajectory, and between gray matter density and age on a decreasing trajectory in VBM and ROI analyses with AIC. Because the trajectory of gray matter volume and density with age suggests the progress of brain maturation, our results may contribute to clarifying brain maturation in healthy children from the viewpoint of brain structure. Hum Brain Mapp, 2013. © 2012 Wiley Periodicals, Inc.
Rapid aerobic oxidation of alcohols to carbonyl compounds with dioxygen using metallodeuteroporphyrin dimethyl esters as catalysts in the presence of isobutylaldehyde
Authors: Sun Chengguo , Hu Bingcheng , Liu Zuliang 
Published: April 2012

AbstractA facile biomimetic method for rapid oxidation of alcohols to carbonyl compounds using dioxygen as the primary oxidant catalyzed by metallodeuteroporphyrin dimethyl ester [M(DPDME)] in acetonitrile as the reaction solvent and isobutylaldehyde as cocatalyst has been investigated. Among the M(DPDME) catalysts, where M = Fe(III), Co(II), Mn(III), Ni(II), Cu(II), and Zn(II), cobalt porphyrin was found to be the most active and effective catalyst. The catalytic system was widely used in the oxidation of various alcohols and especially exhibited excellent activity for oxidation of aromatic alcohols under mild conditions. Moreover, M(DPDME) was prepared from an improved facile method by chemical modification of natural hemin and an alternative mechanism for the aerobic oxidation of alcohols has been proposed and discussed. © 2012 Wiley Periodicals, Inc. Heteroatom Chem 23:295–303, 2012; View this article online at wileyonlinelibrary.com. DOI 10.1002/hc.21017
Direct Controlled Polymerization of Ionic Monomers by Surface‐Initiated ATRP Using a Fluoroalcohol and Ionic Liquids
Authors: Kobayashi Motoyasu , Terada Masami , Terayama Yuki , Kikuchi Moriya , Takahara Atsushi 
Published: April 2012

AbstractSurface‐initiated atom transfer radical polymerization (ATRP) of (2‐methacryloyloxyethyl)trimethylammonium chloride (MTAC), 3‐(N‐2‐methacryloyloxyethyl‐N,N‐dimethyl) ammonatopropanesulfonate) (MAPS), and 2‐methacryloyloxyethyl phosphorylcholine (MPC) was carried out in 2,2,2‐trifluoroethanol (TFE) containing a small amount of 1‐hexyl‐3‐methylimidazolium chloride at 60 °C to produce well‐defined ionic polymer brushes and the corresponding free polymers with predictable number‐average molecular weight (Mn, 1×104−3×105 g mol−1) and narrow molecular weight dispersity (Mw/Mn<1.2). A first‐order kinetic plot for ATRP of MTAC and MAPS revealed a linear relationship between the monomer conversion index (ln([M]0/[M])) and polymerization time. Reduction in polymerization rates was observed with an increase in ionic liquid concentration. The Mn of both poly(MTAC) and poly(MAPS) increased in proportion to the conversion. The sequential polymerization of MAPS initiated with the chain ends of poly(MAPS) produced the postpolymer with quantitative efficiency. The thickness of the polymer brush was controllable from 5 to 100 nm based on the Mn of the polymer. These results suggest the successful control of the polymerization of sulfobetaine‐type methacrylates owing to the TFE and ionic liquids. In particular, the high affinity of TFE for the sulfobetaine monomers and polymers yielded a homogeneous polymerization media to improve surface‐initiated polymerization generating the polymer brushes on the substrate surface as well as the free polymers formed in the solution. The effect on ATRP of the chemical structure of ionic liquids and ligands for copper catalyst was also investigated.
CONTROL OF SWELLING OF SOIL UNDER CANAL LINING BY WETTING AND DRYING CYCLES
Authors: Ahmadi Hojjat , Rahimi Hassan , Rostami Maryam Ebrahimi 
Published: April 2012

ABSTRACTIn the present research, the effects of cyclic wetting and drying on the swelling potential of clayey soils were investigated. For this purpose, three different clayey samples were collected from three irrigation project sites in Iran. The swelling tests were conducted in oedometer cells, where percent swell was measured in five wetting and drying cycles. To investigate the effects of initial moisture content of the soil on swell potential, the samples were tested at moisture contents at, below and above the shrinkage limit. The results of the experiments showed that for all samples, no matter at what the initial moisture content tested, swelling potential was considerably reduced as a result of the wetting and drying cycles. For some samples, maximum reduction in swelling was observed in the second cycle, while for others it occurred in the third or fourth cycle. Copyright © 2012 John Wiley & Sons, Ltd.