bluuebunny/crossref_metadata_2025_split huggingface dataset:
Saudi Arabian Nurses’ Motivations and Barriers to Employment in Inpatient Mental Health Facilities: A Qualitative Investigation
Authors: Alyousef Seham Mansour 
Published: June 2024

Background: The shortage of inpatient psychiatric mental health care nurses in Saudi Arabia represents an important health care challenge. Aim: The aim of this study was to illuminate perspectives of psychiatric mental health nurses employed in psychiatric inpatient settings about their employment experiences. Method: This study adopted an exploratory qualitative approach using thematic content analysis. Ten professional nurses with psychiatric inpatient caring experience participated in two focus groups composed of Master of Nursing students. Results: Four main themes emerged: inadequate professional skills and knowledge for psychiatric mental health care practice, negative public attitudes toward psychiatric/mental health nurses, concerns for personal safety, and alternatives and advantages. The findings of this study suggest that nurses’ lack of interest in working in psychiatric units is not merely personal but also social and organizational. Conclusions: The study findings may encourage managers and authorities to develop measures to attract more mental health nurses to work in psychiatric units. Such strategies may include modification of nurses’ skills, training, and professional knowledge, collegial supervision, mentoring, and working conditions and environment.
Raising Turkish–English bilingual children in Turkey: A qualitative study of parental attitudes, beliefs, and utilized strategies
Authors: Kiliç Ali 
Published: June 2024

Aims and Objectives: This study aimed to explore Turkish parents’ attitudes, beliefs, and strategies while raising their children as Turkish-English bilinguals. Design/Method/Approach: The qualitative research design was adopted. To collect data, semi-structured interviews were carried out via the Zoom platform with the participation of eight volunteers across Turkey. Data Analysis: The data obtained from the interviews were analyzed following the content analysis. The author analyzed on his own. Codes were obtained from the data in the transcripts, categories associated with these codes were formed, and themes were created. Findings/Conclusion: The results show that parents are in favor of raising their children as bilinguals and they are the ultimate decision-makers. In addition to relying on their knowledge mainly, they make use of books and cartoons to support the process. They utilize intentional bilingualism and mostly prefer the one-person-one language (OPOL) strategy. Originality: The study focused on the attitudes, beliefs, and behaviors of parents while raising their children as bilingual. It is one of the very fewest studies carried out in the local context, in Turkey. Significance/implications: The study will provide parents with an overview of the beliefs and used strategies in raising a bilingual child. The study will also be useful for parents who want to raise their kids as bilinguals, particularly in a monolingual country.
A mixed methods evaluation of the music and psychology and social connections (MAPS) pilot – A dyadic intervention for couples affected by young-onset dementia
Authors: Loi FRANZCP PhD MBBS Samantha M , Cadwallader Claire J , Stretton-Smith Phoebe A , Flynn Libby , Wand Anne PF , Bryant Christina , Baker Felicity A 
Published: June 2024

Introduction People living with young-onset dementia and their care-partners are at risk of a range of adverse mental health outcomes and social isolation. There are few interventions aimed at supporting couples affected by young-onset dementia, which poses unique psychosocial challenges for younger people. Methodology This pre-post interventional mixed methods pilot study aimed to assess the feasibility and acceptability of an online group program for people with young-onset dementia and their care-partners living at home in Australia. The Music And Psychology and Social connections (MAPS) program aimed to address: (1) the challenges and changes associated with young-onset dementia; and (2) coping and wellbeing. The program involved six weekly two-hour sessions co-facilitated by a psychologist and music therapist, and a private Facebook group. The primary outcomes of feasibility and acceptability were assessed through a post-program focus group, separate individual feedback sessions with each couple, and a program evaluation questionnaire. Thematic analysis was conducted on the focus group transcripts and field notes from couple feedback sessions. We also examined the preliminary utility of MAPS in improving mental health and social connectedness, using quantitative pre-post-measures. Results Five couples completed the MAPS program. The most common dementia type was Alzheimer’s Disease. Participant attendance was 87% across all sessions. Qualitative findings supported acceptability of the program with four emergent themes: being connected to others with shared experiences; reframing thoughts and feelings about dementia; music as a therapeutic tool; and benefits of MAPS. Conclusion The high retention rate, qualitative findings and positive program evaluation suggest MAPS may be a promising, feasible and acceptable program for couples affected by young-onset dementia.
Effects of A2 Pulley Venting on Bowstringing and Tendon Slack: A Biomechanical Investigation
Authors: Shipley Tyler , Vanhoof-Villalba Stephanie Leah , Lee Seokgi , Saxena Tara , Adcock William , Bilderback Karl , Barton R. Shane , Solitro Giovanni F. 
Published: June 2024

Background: A2 pulley release is often needed for exposure of the lacerated tendon, retrieval of retracted tendons, placement of core sutures, or to permit full motion and gliding of the repaired and edematous tendon. However, there is no agreement in the literature on the specific quantity of pulley venting that can be performed and recommendations are limited to an undefined “judicious release” of the pulleys when necessary. Methods: Following a previously developed testing protocols, finger kinematics, tendon excursion, and bowstringing were evaluated on cadaveric hands for venting in increments of 20% of the pulley length. Results: In our study, we found a statistically significant influence of venting on bowstringing, although no difference was found between fingers, and a significant difference in tendon slack, which was variable depending on the finger. Bowstringing started increasing at 20% of A2 venting and peaked at full release. Tendon slack did not start until 40% of A2 venting on the index finger, but started at 20% on the middle, ring, and small fingers. Conclusions: Venting of the A2 pulley leads to an incremental increase in tendon bowstringing and tendon slack. However, differences in metacarpophalangeal flexion angle were not observed until full A2 pulley release, and only observed in the index finger, and no differences were observed in proximal interphalangeal flexion angles. Therefore, the benefit of releasing the A2 pulley when clinically necessary will likely outweigh the risks of loss of motion or strength.
Regulation of Osteosarcoma Cell Proliferation, Migration, and Invasion by miR-143 and miR-199a Through COX-2 Targeting
Authors: Bixin Huang , Yuling Zheng , Ying Mai , Jinming Chen , Zhang Zhongqi 
Published: June 2024

Objective To investigate the biological role of miR-143 and miR-199a in mediating the progression of osteosarcoma (OS) by targeting cyclooxygenase (COX-2). Introduction COX-2 plays a crucial role in the development and progression of OS. However, the specific regulatory mechanisms of COX-2 in OS are still not well understood. Methods The expression levels of COX-2, miR-143 and miR-199a in OS tissues were detected using immunohistochemistry, qPCR, or western blot assays. The targeting relationship between miRNAs and COX-2 was determined. The effect of miRNA and COX-2 on OS cells was evaluated in vitro and in vivo. Results COX-2 expression was upregulated while miR-143 and miR-199a were downregulated in OS tissues. miR-143 and miR-199a suppressed the proliferation, migration, and invasion of OS cells. The dual-luciferase reporter gene assay showed that COX-2 was a direct target of miR-143 and miR-199a. Genetic knockdown of COX-2 significantly suppressed cell proliferation, induced apoptosis, and inhibited migration and invasion of OS cells. The expression levels of COX-2 and PGE2 were decreased after the overexpression of miR-143 and miR-199a. Additionally, COX-2 silencing inhibited the tumorigenesis of OS and the synthesis of PGE2 in vivo. Conclusions miR-143 and miR-199a/COX-2 axis modulates the proliferation, invasion, and migration in osteosarcoma.
Evaluation of circulating CD4+CD25+CD127−/low regulatory T cells in newly diagnosed hepatitis C-infected patients
Authors: Asadipour Morvarid , Khansalar Soolmaz , Rezaei Kahmini Fatemeh , Eshkevar Vakili Mahsa , Ataollahi Mohammad Reza , Ali-Hassanzadeh Mohammad , Shams Keivan , Faghih Zahra , Kalantar Kurosh 
Published: June 2024

Objectives Hepatitis C virus (HCV) is one of the most global health problems with 2.5% prevalence worldwide. It seems that regulatory T (Treg) cells, which are able to modulate the host immune responses, play a substantial role in the immunopathogenesis of HCV infection. In this study, we evaluated the distribution of Treg cells in HCV-infected patients and its correlation with viral load and clinical manifestations. Methods Peripheral blood mononuclear cells (PBMCs) were collected from 14 newly diagnosed HCV-infected patients and 23 age- and sex-matched healthy subjects, and the frequency of CD4+CD25+CD127−/low Treg cells was determined by flow cytometry. Results Our results showed that the mean level of CD4+CD25+CD127−/low Treg cells in HCV-infected patients was significantly higher than that in healthy control subjects (8.2 ± 1.48% vs 5.4 ± 0.36%, p < .05). However, there was no statistical correlation between Treg cells frequency and viral load or clinical manifestations. Conclusion A higher proportion of Treg cells in HCV-infected patients might indicate their critical role in viral persistence and candidate them as a new target of immunotherapy to improve antiviral immunity.
Anatomical distribution and treatment of paediatric hand fractures: a multi-centre study of 749 patients in the Netherlands
Authors: de Haas Louise , van Oorschot Hanneke , van Hoorn Bastiaan , de Bruin Ivar , Schep Niels , van Heijl Mark ,   Snapshot Hand Fractures Collaborative Study Group
Published: June 2024

This study describes the anatomical distribution of paediatric metacarpal and phalangeal fractures and evaluates treatment methods for each fracture type. A multicentre study was conducted over a 3-month period in the Netherlands. A total of 749 consecutive patients, aged 0–17 years, with single metacarpal or phalangeal fractures were included. Physeal fractures of the proximal phalanx were most common ( n = 135, 17%), followed by proximal interphalangeal joint palmar plate avulsion fractures ( n = 81, 10%) and proximal phalanx shaft fractures ( n = 80, 10%). Treatment methods varied: 63 (47%) patients with proximal phalanx physeal fractures were allowed mobilisation of their fingers, while 70 (51%) were immobilised; 53 (65%) patients with proximal interphalangeal joint palmar plate avulsion fractures were allowed mobilisation, while 28 (35%) were immobilised; and 33 (41%) patients with proximal phalanx shaft fractures were allowed mobilisation, while 42 (52%) were immobilised. The study identified substantial treatment variability in common fractures, providing information and insights for future research directions. Level of evidence: II
Severe (>100 Degrees) Thoracic Adolescent Idiopathic Scoliosis – A Comparison of Surgical Approaches
Authors: Stone Lauren E. , Newton Peter O. , Catanzano Anthony A. , Oba Hiroki , Lenke Lawrence G. , Boachie-Adjei Oheneba , Kelly Michael P. , Gupta Munish C. ,   Harms Study Group,   Fox Study Group
Published: June 2024

Study Design Retrospective. Objective Severe curves >100° in adolescent idiopathic scoliosis (AIS) are rare and require careful operative planning. The aim of this study was to assess baseline, perioperative, and 2-year differences between anterior release with posterior instrumentation (AP), posterior instrumentation with posterior column osteotomies (P), and posterior instrumentation with 3-column vertebral osteotomies (VCR). Methods Two scoliosis datasets were queried for primary cases of severe thoracic AIS (≥100°) with 2-year follow-up. Pre- and 2-year postoperative radiographic measures (2D and estimated 3D kyphosis), clinical measurements, and SRS-22 outcomes were compared between three approaches. Results Sixty-one patients were included: 16 AP (26%), 38 P (62%), 7 VCR (11%). Average age was 14.4 ± 2.0 years; 75.4% were female. Preoperative thoracic curve magnitude (AP: 112°, P: 115°, VCR: 126°, P = 0.09) and T5-T12 kyphosis (AP: 38°, P: 59°, VCR: 70°, P = 0.057) were similar between groups. Estimated 3D kyphosis was less in AP vs P (−12° vs 4°, P = 0.016). Main thoracic curves corrected to 36° in AP vs 49° and 48° for P and VCR, respectively ( P = 0.02). Change in estimated 3D kyphosis was greater in AP vs P and VCR (34° vs 13°, P = 0.009; 34° vs 7°, P = 0.046). One incomplete spinal cord injury had residual deficits (P; 1/61, 1.6%). All SRS-22 domains improved postoperatively. Conclusion All approaches obtained satisfactory coronal and sagittal correction, but AP had smaller residual coronal deformity and greater kyphosis restoration than the other approaches. This information may help inform the decision of whether to include an anterior release for large thoracic AIS curves.
Emerging genetic technologies informing personalized medicine in Shwachman-Diamond syndrome and other inherited BMF disorders
Authors: Cull Alyssa H. , Kent David G. , Warren Alan J. 
Published: June 2024

Abstract
Ribosomopathy Shwachman-Diamond syndrome (SDS) is a rare autosomal recessive inherited bone marrow failure syndrome (IBMFS) caused by mutations in the Shwachman-Bodian-Diamond syndrome gene, which is associated with an increased risk of myeloid malignancy. Tracking how hematopoietic stem cell (HSC) clonal dynamics change over time, assessing whether somatic genetic rescue mechanisms affect these dynamics, and mapping out when leukemic driver mutations are acquired is important to understand which individuals with SDS may go on to develop leukemia. In this review, we discuss how new technologies that allow researchers to map mutations at the level of single HSC clones are generating important insights into genetic rescue mechanisms and their relative risk for driving evolution to leukemia, and how these data can inform the future development of personalized medicine approaches in SDS and other IBMFSs.
How I treat infant acute lymphoblastic leukemia
Authors: Bartram Jack , Ancliff Philip , Vora Ajay 
Published: June 2024

Abstract
Infant acute lymphoblastic leukemia (ALL) is an aggressive malignancy that has historically been associated with a very poor prognosis. Despite large cooperative international trials and incremental increases in intensity of therapy, there has been no significant improvement in outcome over the last 3 decades. Using representative cases, we highlight the key differences between KMT2A-rearranged and KMT2A–germ line infant ALL, and how advances in molecular diagnostics are unpicking KMT2A–germ line genetics and guiding treatment reduction. We focus on KM2TA-rearranged infant B-cell ALL for which the last few years have seen the emergence of novel therapies that both are more effective and less toxic than conventional chemotherapy. Of these, there is promising early data on the efficacy and tolerability of the bispecific T-cell engager monoclonal antibody, blinatumomab, as well as the use of autologous and allogeneic chimeric antigen receptor T-cell therapy. We discuss how we can improve risk stratification and incorporate these new agents to replace the most toxic elements of currently deployed intensive chemotherapy schedules with their associated unacceptable toxicity.
Genome-wide identification and mining elite allele variation of the Monoacylglycerol lipase (MAGL) gene family in upland cotton (Gossypium hirsutum L.)
Authors: Zhou Zhibin , Chen Yao , Yan Mengyuan , Zhao Shuqi , Li Feifei , Yu Shuxun , Feng Zhen , Li Libei 
Published: June 2024

Abstract
Background
Monoacylglycerol lipase (MAGL) genes belong to the alpha/beta hydrolase superfamily, catalyze the terminal step of triglyceride (TAG) hydrolysis, converting monoacylglycerol (MAG) into free fatty acids and glycerol.

Results
In this study, 30 MAGL genes in upland cotton have been identified, which have been classified into eight subgroups. The duplication of GhMAGL genes in upland cotton was predominantly influenced by segmental duplication events, as revealed through synteny analysis. Furthermore, all GhMAGL genes were found to contain light-responsive elements. Through comprehensive association and haplotype analyses using resequencing data from 355 cotton accessions, GhMAGL3 and GhMAGL6 were detected as key genes related to lipid hydrolysis processes, suggesting a negative regulatory effect.

Conclusions
In summary, MAGL has never been studied in upland cotton previously. This study provides the genetic mechanism foundation for the discover of new genes involved in lipid metabolism to improve cottonseed oil content, which will provide a strategic avenue for marker-assisted breeding aimed at incorporating desirable traits into cultivated cotton varieties.
Adoption of the cardiopulmonary exercise test in the exercise ability and cardiopulmonary function rehabilitation of coronary artery disease (CAD) patients
Authors: Wang Lingling , Mei Fan , Min Mengyi , He Xiuyan , Luo Lili , Ma Youxia 
Published: June 2024

Abstract
Background
This study aimed to explore the application of cardiopulmonary exercise testing in coronary artery disease (CAD) patients, evaluate its impact on exercise ability and cardiopulmonary function in patients with coronary heart disease (CHD), and promote the application of cardiopulmonary exercise testing in CAD management.

Methods
Fifty CHD patients after percutaneous coronary intervention (PCI) were recruited and randomly enrolled into the control (Ctrl) group and intervention (Int) group. Routine health education and health education combined with RT training were carried out for the two groups. Blood lipid levels and lung function were compared between the two groups after intervention. Cardiac function was evaluated by Doppler ultrasonography, and cardiopulmonary fitness and exercise ability were evaluated by a cardiopulmonary exercise test (CPET). The self-rating anxiety scale (SAS) and self-rating depression scale (SDS) were employed to evaluate negative emotions. The 36-item short-form (SF-36) was adopted to evaluate quality of life.

Result
: Compared with those in the Ctrl group, the levels of serum total cholesterol (TC), triglycerides (TGs), high-density lipoprotein (HDL), and low-density lipoprotein (LDL) decreased in the Int group, while the levels of high-density lipoprotein increased (P < 0.05). The quantitative load results showed that compared with the Ctrl group, the heart rate (HR) and self-perceived fatigue degree of the Int group decreased, and the ST segment increased (P < 0.05). Compared with the Ctrl group, the left ventricular ejection fraction (LVEF), forced expiratory volume at 1 s (FEV1), ratio of forced expiratory volume to forced vital volume (FEV1/FVC%), and maximum chase volume (MVV) increased in the Int group, while the left ventricular end diastolic diameter and left ventricular end contractile diameter decreased (P < 0.05). The results of the CPET showed that compared with the Ctrl group, minute ventilation/carbon dioxide production slope, VE/VCO2 − Peak, anaerobic threshold (AT), peak oxygen pulse (VO2/HR peak), oxygen uptake efficiency platform (OUEP), increasing power exercise time (IPEt), HR recovery 1 min after exercise, peak load power (Watt peak), and value metabolic equivalent (Watt peak) increased in the Int group (P < 0.05). Compared with the Ctrl group, the SAS and SDS scores in the Int group decreased (P < 0.05). The results of the quality of life evaluation showed that compared with the Ctrl group, the score of the SF-36 dimensions increased in the Int group (P < 0.05).

Conclusion
RT training can reduce postoperative blood lipid and quantitative load levels in CAD patients and improve adverse mood. Furthermore, it can improve patients’ cardiopulmonary function, cardiopulmonary fitness, exercise ability, and quality of life.
The evolution of TAVI performance overtime: an overview of systematic reviews
Authors: Angioletti Carmen , Moretti Giaele , Manetti Stefania , Pastormerlo Luigi , Vainieri Milena , Passino Claudio 
Published: June 2024

Abstract
Background
Transcatheter aortic valve implantation (TAVI) is a well-established treatment for high and intermediate-risk patients with severe aortic stenosis (AS). Recent studies have demonstrated non-inferiority of TAVI compared to surgery in low-risk patients. In the past decade, numerous literature reviews (SLRs) have assessed the use of TAVI in different risk groups. This is the first attempt to provide an overview of SRs (OoSRs) focusing on secondary studies reporting clinical outcomes/process indicators. This research aims to summarize the findings of extant literature on the performance of TAVI over time.

Methods
A literature search took place from inception to April 2024. We searched MEDLINE and the Cochrane Library for SLRs. SLRs reporting at least one review of clinical indicators were included. Subsequently, a two-step inclusion process was conducted: [1] screening based on title and abstracts and [2] screening based on full-text papers. Relevant data were extracted and the quality of the reviews was assessed.

Results
We included 33 SLRs with different risks assessed via the Society of Thoracic Surgeons (STS) score. Mortality rates were comparable between TAVI and Surgical Aortic Valve Replacement (SAVR) groups. TAVI is associated with lower rates of major bleeding, acute kidney injury (AKI) incidence, and new-onset atrial fibrillation. Vascular complications, pacemaker implantation, and residual aortic regurgitation were more frequent in TAVI patients.

Conclusion
This study summarizes TAVI performance findings over a decade, revealing a shift to include both high and low-risk patients since 2020. Overall, TAVI continues to evolve, emphasizing improved outcomes, broader indications, and addressing challenges.