bluuebunny/crossref_metadata_2025_split huggingface dataset:
ПРАВОВОЕ РЕГУЛИРОВАНИЕ ВЗАИМОДЕЙСТВИЯ ГОСУДАРСТВА И ИНСТИТУТОВ ГРАЖДАНСКОГО ОБЩЕСТВА: УКРЕПЛЕНИЕ ТРАДИЦИОННЫХ ЦЕННОСТЕЙ
Authors: ЦВЕТКОВА Наталия Борисовна 
Published: June 2024

В статье проанализированы новые для теории и практики изменения в области правового регулирования взаимодействия государства и институтов гражданского общества, которые связаны с развитием цифровых технологий и применением искусственного интеллекта в области государственного управления. Исследуется феномен цифровизации в контексте развития правового регулирования. Описаны основные аспекты правового регулирования сферы цифровых технологий и применения искусственного интеллекта (ИИ) в сфере государственного управления и сфере развития гражданского общества в России и других странах. Рассмотрены существующие вызовы и риски применения цифровых технологий в сфере государственного управления.
ОСОБЕННОСТИ ПРЕДОСТАВЛЕНИЯ ИНФОРМАЦИИ С ИСПОЛЬЗОВАНИЕМ РЕКОМЕНДАТЕЛЬНЫХ СИСТЕМ КАК СУБТЕХНОЛОГИИ ИСКУССТВЕННОГО ИНТЕЛЛЕКТА
Authors: САВЧЕНКО Елена Алексеевна , СЕМЁНОВ Сергей Васильевич 
Published: June 2024

С 1 октября 2023 г. вступили в силу поправки в Закон об информации, устанавливающие особенности предоставления информации с применением рекомендательных технологий, которые, как правило, используют для продвижения товаров и услуг, вовлечения интернет-пользователей и удержания их внимания.
Рекомендательные технологии используют для проведения анализа запроса пользователя системой искусственного интеллекта, для подбора и предложения пользователю близких по форме и содержанию товаров и услуг. Использование рекомендательных технологий для анализа с помощью систем искусственного интеллекта предпочтений пользователей сети Интернет пока находится на начальном этапе правового регулирования. Однако вопрос, как обозначить границы применения рекомендательных алгоритмов, пока не решен.
Artificial saliva plus beta-glucan for treatment of xerostomia in older adults: The clinical study of effectiveness and salivary total antioxidant capacity levels
Authors: Tachasuttirut Kathawut , Tanviruch Pakawan , Pongsiriwet Surawut , Ittichaicharoen Jitjiroj , Korwanich Kanyarat 
Published: June 2024

To evaluate the effectiveness of 2 artificial saliva formulations, sodium carboxymethylcellulose artificial saliva spray and sodium carboxymethylcellulose artificial saliva spray plus β-glucan.: This study was a double-blind randomized controlled trial and involved older adults with xerostomia. The xerostomia inventory score, clinical oral dryness score, oral moisture degree, unstimulated salivary flow rate, and salivary total antioxidant capacity were measured prior to and after treatment. The results were evaluated 4 weeks after taking both products. : The study included 51 subjects in the control (n = 25) and BG (n = 26) groups. xerostomia inventory score and clinical oral dryness score were significantly lower in both groups after 4 weeks of treatment (p&#60;0.00). Additionally, both groups had significantly greater oral moisture degree and unstimulated salivary flow rate than before treatment (p&#60;0.05). Only the increase in oral moisture degree in the BG group was significantly greater than that in the control group (p=0.048). Both groups tended to have decreased salivary total antioxidant capacity, but only the control group had a significant difference at 4 weeks (p=0.004). There was no significant difference in satisfaction score between the two groups. No serious side effects were found in the study. : The clinical signs and symptoms of xerostomia were improved by both control and artificial BG saliva. BG improved oral moisture more than the control. Furthermore, BG was more likely to prevent a decrease in salivary total antioxidant capacity than was the control.
Corncob Hydrolysis Using Graphene Oxide Activated Coconut Shell Biochar Catalyst
Authors: Igboke Ogechukwu Jude , Orimolade Temitope , Jani Charmy , Odejobi Oludare Johnson , Krishnan Sitaraman 
Published: June 2024

Abstract

Purpose: Graphene oxide (GO) synthesized by Hummers method is an effective catalyst for biomass hydrolysis and sugar production. However, due to its small size and hydrophilicity, its post-reaction separation by filtration of the aqueous reaction mixture is challenging. Therefore, GO was supported on larger biochar particles, and the catalytic activity of the composite particles was evaluated.
Methods: Mesoporous biochar was prepared using phosphoric acid-activated coconut shell at a relatively low carbonization temperature of 450 °C. The catalytic activity of the biochar-supported GO catalyst on corncob hydrolysis was investigated using the I-optimal response surface methodology. Neat GO and sulfonated high-temperature biochar (SBC700) were used as references.
Results: Optimized reaction conditions for high sugar yields were identified. Under these conditions, the biochar-supported catalyst showed a sugar yield comparable to neat GO and SBC700 despite its lower sulfonic acid density. The biochar-supported catalyst could be recycled and reused with about 35 % decrease in the sugar yield after the first use. A similar reduction in the activity of SBC700 suggested no significant loss of GO from the biochar-supported catalyst under the hydrolysis conditions.
Conclusion: The sugar yield per unit mass of corncob was found to be linearly dependent on the catalyst concentration and the reaction time. The acid density, a measure of the concentration of acidic groups on the catalyst surface, is an important factor determining the catalytic activity. The study suggests that increasing the acid density by augmenting the GO loading of the biochar particles could lead to higher sugar yields.
Access Control System Based on Blockchain and Puncturable Attribute Based Encryption for Data Privacy on Content Centric Networks
Authors: Affum Eric 
Published: June 2024

Abstract

In a novel content centric network paradigm where content can be cached in-network and at the edge of the network, attribute based encryption (ABE) is considered to be a vital cryptography scheme to address data privacy and fine-grained access control issues. Nevertheless, the ABE scheme suffers from ineffectiveness, attributes revocations, and relies on a centralized conventional public key infrastructure with a key escrow problem and a single point of failure that could lead to a system collapse. Hence, we propose an effective access control mechanism for the Internet of Things content centric network by combining the puncturable ABE scheme with blockchain public key management. The effectiveness of our scheme is accomplished by utilizing a reduced order binary decision diagram for the definition of the access structure employed for our proposed scheme. The problem associated with key updates is solved by using the puncturable property of our ABE scheme. We also adopted a blockchain key management approach with the advantages of decentralized and tamper-proof design features to register, query, update keys, and verify and revoke a user's access capability. We simulated our scheme, and the experimental results indicate that our scheme is practical.
Evaluating the efficacy of Radically Open Dialectical Behavior Therapy (RO-DBT) in patients with anorexia nervosa: study protocol for a randomized controlled clinical trial
Authors: Avila-Parcet Aina , Martín-Blanco Ana , Gawron Leonor , Cano Marta , Peña-Arteaga Víctor De La , Carceller-Sindreu Mar , Soler Joaquim , Portella Maria J , Faustino Gloria , Cardoner Narcís , Farrés Cristina Carmona 
Published: June 2024

Abstract

Background: Anorexia nervosa (AN) is a severe and disabling disorder, with relapse rates as high as 50% after the first episode, posing a significant challenge for clinicians. Most therapies excessively focus on nourishment, resulting in temporary weight restoration but with no improvements in general well-being and quality of life. Radically Open Dialectical Behavior Therapy (RO-DBT) is a transdiagnostic treatment designed to address overcontrol, a key aspect in the functioning of patients with AN. To date, no clinical trial (CT) has proven its efficacy in these patients or evaluated its neurobiological mechanism of action.
Methods: A randomized CT in AN patients will be conducted, with one group receiving treatment as usual (TAU) and the other TAU plus RO-DBT, with the main outcome being quality of life. Secondary variables will include eating disorders (EDs) symptoms, overcontrol characteristics, autistic traits, and neuroimaging changes.
Discussion: The results will address a gap in knowledge regarding AN treatment, with the expectation that patients receiving TAU with RO-DBT will exhibit improved quality of life and experience fewer relapses at the one-year follow-up. This is the first study examining neuroimaging changes in RO-DBT to better understand its underlying mechanisms.
Trial registration: The study has been registered in ClinicalTrials.gov in September 22, 2023.
It can be found in https://classic.clinicaltrials.gov/ct2/show/NCT06050421.
Trial Registration Number: NCT06050421
Cocoa bean (Theobroma cacao L.) oil and acetone extract fractions ameliorative role on impaired lipid profile measured in Streptozotocin (STZ) induced hyperglycemic rats
Authors: Akataobi Uche. 
Published: June 2024

Abstract

This study investigated the ameliorative role of cocoa bean (Theobroma cacao L.) oil and acetone extract fractions of on lipid profile of STZ induced hyperglycemic rats. Thirty five (35) albino rats weighing 160 g -180 g were divided into seven groups. Six (6) groups were injected 60 mg/kg body weight STZ, five of the 6 injected groups was treated with oral 500 ml/kg oil-PE, oil-UnPE oil and 500 mg/kg standard drug (SC), peeled (PE), unpeeled (Un-PE) acetone extracts, fractions of cocoa bean, while the last 2 groups were similarly given water for 28 days. All the groups were sacrificed under 0.4ml ketamine injected intra-peritoneal, blood was collected via cardiac puncture to obtain serum. Result obtained showed that STZ induced hyperglycemia significant (p < 0.05) increased fasting blood glucose, cholesterol, triglyceride, low and very low density lipoprotein cholesterol concentrations while high density lipoproitein cholesterol concentration were reduced. Treatment with cocoa oil and acetone extract fractions significantly (P < 0.05) reduced fasting blood glucose, TG, CHO, LDL, VLDL-C concentrations and increased HDL-C concentration which occurred more in oil treated groups. The study concludes that oil and acetone extracts fraction of cocoa beans posses effective lipid lowering potentials which may be helpful in the treatment of dyslipidemia associated with hyperglycemia.
Body-to-brain Insulin and Notch signaling regulates memory through neuronal CREB activity
Authors: Murphy Coleen 
Published: June 2024

Abstract

While we think of memory regulation as autonomous to neurons, factors outside the brain can also affect neuronal function. In C. elegans, the insulin/IGF-1-like signaling (IIS) pathway regulates longevity1, metabolism2,3, and memory4,5: long-lived daf-2 insulin/IGF-1 receptor mutants more than double memory duration after a single training session. It was assumed that this regulation was strictly neuronal, but we discovered that degradation of DAF-2 in the hypodermis also greatly extends memory via expression of the diffusible Notch ligand, OSM-11, which in turn activates Notch signaling in neurons. Single-nucleus RNA-sequencing of neurons revealed activation of CREB memory genes and CREB itself. Finally, we found that activation of the hypodermal IIS/Notch/CREB pathway as well as OSM-11 overexpression in aged animals rescues both learning and memory. Thus, insulin signaling in the liver-like hypodermis6 non-autonomously regulates neuronal function, providing a systemic connection between metabolism and memory through IIS/Notch/CREB signaling from the body to the brain.
Effectiveness of Mindfulness-Based Stress Reduction on Mental Health, Salivary Cortisol and α-amylase level in students: A Randomized and Parallel-Group Clinical Trial
Authors: shahyad shima , Mohammadzadeghan Reza , Saadat Seyed Hassan , Hatef Boshra , Jahromi Gila Pirzad , Hassanvandi Saba 
Published: June 2024

Abstract

Background
The current trial aimed to assess the effectiveness of Mindfulness-Based Stress Reduction training on the level of mental health, salivary cortisol and α-amylase levels of students.
Methods
This research was an experimental trial with a pre-test-post-test design and a control group. The statistical population of the research included all students studying in the universities of Khoy, Iran in 2021. The sample consisted of 30 people who were selected by randomized sampling and were assigned to two experimental and control groups. Stress, anxiety and depression scale (DASS-21), General Health Questionnaire (GHQ-28) and saliva samples were passively taken by ELISA laboratory method with special kits. Data analysis was done using an independent t-test and analysis of covariance using IBM-SPSS version 26 software.
Results
The results showed that MBSR training on general health, alpha-amylase level and alpha-amylase/cortisol ratio of experimental group participants was more effective than the control group (P < 0.05). However, it was not effective on students' cortisol levels (P > 0.05).
Conclusions
According to the findings, it can be argued that MBSR training has been able to promote the psychological (DASS and general health) and hormonal (alpha amylase level and alpha-amylase/cortisol ratio) mental health indicators of the experimental group participants compared to the control group.
DEER Study of Spatial Arrangement of Spin-labeled Diclofenac in Lipid Bilayers of Different Composition
Authors: Kashnik Anna S. , Atnyukova Anastasiya N. , Baranov Denis S. , Dzuba Sergei A. 
Published: June 2024

Abstract

Diclofenac is a non-steroidal anti-inflammatory drug (NSAID). Here we employ double electron-electron resonance (DEER, also known as PELDOR) to study the interaction of spin-labeled diclofenac (diclofenac-SL) with the model membrane of three types: palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (POPC), equimolar mixture of 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC) and 1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC), and this mixture with 20 mol% of cholesterol added. The results suggest that lipid-mediated lateral clustering of diclofenac-SL molecules occurs in all cases, but in very different ways. For the POPC bilayer, alternative clustering takes place in two opposite leaflets, with random distribution of the molecules within the clusters. For DOPC/DPPC and DOPC/DPPC/cholesterol bilayers, diclofenac-SL molecules are separated by a distance of at least 1.4 nm. DOPC/DPPC/cholesterol bilayers are known to form nanoscale liquid disordered and liquid ordered lateral structures, the latter called lipid rafts. For this case, diclofenac-SL molecules were found to be captured by lipid rafts, forming a quasi-regular two-dimensional substructure in them with a "superlattice" parameter of ~ 3.0 nm.
An Incremental Lightweight Method for Vulnerability Data Collection for Security Patches
Authors: Bhandari Guru , Gavric Nikola 
Published: June 2024

Abstract

Automated Program Repair enhances developers’ efficiency by reducing the time dedicated to debugging and fixing source code vulnerabilities. However, the existing datasets utilized to train patch generation models suffer from various limitations, notably the limited bug context, limited size, and reliance on synthetic and unrealistic source code samples. Additionally, existing dataset extraction tools lack an incremental approach, rendering the inclusion of new data a resource-intensive endeavor in terms of both time and computational resources. In this paper, we introduce FixMe , a novel framework designed for generating patches across diverse programming languages. This open-source tool facilitates an incremental approach to gathering vulnerability records from the Common Vulnerabilities and Exposures (CVE) database. Incorporating an incremental methodology accelerates the data acquisition process, encompassing newly identified vulnerabilities and their corresponding patch pairs. Our dataset curation method involves the extraction of security issues, acquiring vulnerability-fixing commits, and extracting source code from relevant projects. The resultant dataset comprises 18,063 CVEs from 2,133 commits, encompassing 19,109 patch sets with 44,059 vulnerability-fix pairs (patch hunks). This dataset spans 884 open-source projects hosted in git-based systems. Additionally , the study explores fostering the potential of APR techniques in reducing debugging costs and improving software quality by generating patches for fixing vulnerabilities automatically.
Decoding the respiratory microbiome alterations in OVA sensitized asthmatic mice caused by CpG-ODN by 16srRNA gene sequencing method
Authors: Ji Jingjing , Wang Qingqing , Xiao Shuaijun , Yan Xuebo , Fang Lei , Ding Peishan , Wang Jiong 
Published: June 2024

Abstract

Aims: The 16srRNA gene sequencing method was employed to examine the alterations in the nasopharyngeal and pulmonary microbiome of asthmatic mice following CpG-ODN treatment, thereby offering a novel approach to the diagnosis and treatment of asthma.
Methods: Ovalbumin (OVA) sensitized mice were used to establish allergic asthma model by weekly intraperitoneal injection of OVA for three consecutive weeks, and CpG-ODN was inhaled before inducing acute asthma on the 21st and 22nd day. Subsequently, 16srRNA gene sequencing technology was performed to analyse the alterations in the nasopharyngeal and pulmonary microbiome of OVA-sensitized asthma-induced mice following CpG-ODN treatment.
Results: CpG-ODN can significantly ameliorate pathological alterations such as inflammatory cell infiltration in the respiratory tract and clinical manifestations of OVA-induced allergic asthma. The treatment of CpG-ODN exhibits distinct effects on lung tissue and nasopharyngeal tissue, potentially enhancing the abundance and variety of microbiome in the latter. At the phylum level, OVA-induced asthma resulted in an increase in the proportion of Proteobacteria in lung and nasopharyngeal tissues, accompanied by a decline in the proportion of Actinobacteria. Subsequent intervention using CpG-ODN successfully restored the proportions of Proteobacteria and Actinobacteria to near-control levels. At the order level, the proportion of Bacteroidales, Clostridiales, and Actinomycetales in lung tissue diminished following OVA sensitization. Subsequent to CpG-ODN treatment, the proportion of the above three bacterial orders escalated and approximated the proportion of the control group. The proportion of Lactobacillales in nasopharyngeal tissues diminished following OVA sensitization, and it tended to approach the level of the control group after the treatment of CpG-ODN. The microbial diversity of the lung tissue in OVA-induced asthmatic mice exhibits a decline, while the microbial diversity of the nasopharyngeal tissue demonstrates an increase.
Conclusions: The treatment of CpG-ODN has been shown to reverse the alterations in microbiome associated with OVA-induced asthma, thereby promoting a stabilization of the respiratory tract microbiome in OVA-sensitized asthma model mice.
Assessing the Efficacy and Quality of Life Improvements of Botulinum Toxin Type A With Topical Minoxidil versus Topical Minoxidil in Male Androgenetic Alopecia: A Randomized Controlled Trial
Authors: Yu Linli , Moorthy Sathishkumar , Li Xutong , Peng Lin , Zhang Zikai , Shen Liangliang , Han Yu , Huang Xin 
Published: June 2024

Abstract

Androgenetic alopecia (AGA) is a common type of hair loss in men and efficacy and safety of current medical treatment remain limited. Therefore, the present study aimed to investigate the efficacy and safety of botulinum toxin type A (BTA) combined with Minoxidil in patients with AGA. 60 male patients were included in this study and control group received topical 5% Minoxidil and the treatment group received BTA combined with topical 5% Minoxidil. BTA injections (60–70 U) were administered at 30–35 scalp sites. Head photographs were taken at baseline, 2nd, 4th, and 6th months. Clinical descriptions recorded scalp conditions, and patient satisfaction along with Dermatology Life Quality Index scores were documented. The treatment group (TG) showed significant hair growth differences compared to the control group (CG) at the 4th month (P < 0.001) and 6th month (P = 0.0046) post-treatment. TG had improved Investigator Global Assessment (IGA) scores in the 4th month (P = 0.0001) and 6th month (P = 0.0259) compared to CG. Patient satisfaction in TG for hair growth and scalp improvement was higher than CG (all P < 0.05). TG exhibited substantial quality of life improvement at the 4-month (P = 0.0009) and 6-month (P = 0.0099). No adverse reactions were observed post-botulinum toxin injection. BTA combined with Minoxidil effectively promotes hair growth, enhances the quality of life, and alleviates scalp symptoms in male AGA patients at 4th and 6th months, with no adverse effects compared to Minoxidil alone. Trial registration number: Ethics Committee of Shanghai Tongji Hospital (ID: K-2018-026).
Impact of Water, Sanitation, and Hygiene Components on Under-5 Children's Mortality in Ethiopia: A Comparative Analysis of Count Regression Models
Authors: Chafamo Melkamu , Muniswamy B. , Punyavathi B. 
Published: June 2024

Abstract

Objectives To investigates the effect of WASH components on under 5 children mortality and Compare the performance of count advanced count regression models.
Design In this study, data on Water, Sanitation, and Hygiene Components on Under-5 Children's Mortality in Ethiopia participating in the Ethiopian Demographic and Health survey conducted at 2019. The cross-sectional study design was used to study the Demographic and Health data from 11 different regions of Ethiopia. R programming has been used to analyse descriptive and inferential statistics. The baseline Poisson regression model exhibited overdispersion, leading to the exploration of various count regression models. The Negative Binomial regression model emerged as the best fit for the data, displaying low Akaike Information Criterion (AI) values.
Setting Women of reproductive Age 15-49 with Under-Five children were interviewed.
Participants A total of 5753 women of reproductive Age 15-49 with Under-Five children were interviewed.
Primary Outcome Measure The number of under-5 children death, that is count variable.
Results The study reveals Significant factors influencing under 5 children's mortality were identified, including rural residence, inadequate toilet facilities, reliance on unsafe water sources, household access to radios, and household composition.
Conclusion Children living in rural areas faced a significantly higher risk of mortality compared to urban counterparts. Furthermore, households lacking proper sanitation facilities or using unsafe water sources exhibited elevated mortality rates among under-5-year-olds. Conversely, households with radios showed a lower risk of under-5-year-old child deaths. The number of children in a household under the age of five and female-headed households were associated with lower mortality rates.