bluuebunny/crossref_metadata_2025_split huggingface dataset:
The role and impact of viruses on cancer development
Authors: Contreras Adolfo , Sánchez Sandra Amaya , Rodríguez‐Medina Carolina , Botero Javier Enrique 
Published: April 2024

AbstractThis review focuses on three major aspects of oncoviruses' role in cancer development. To begin, we discuss their geographic distribution, revealing that seven oncoviruses cause 20% of all human cancers worldwide. Second, we investigate the primary carcinogenic mechanisms, looking at how these oncogenic viruses can induce cellular transformation, angiogenesis, and local and systemic inflammation. Finally, we investigate the possibility of SARS‐CoV‐2 infection reactivating latent oncoviruses, which could increase the risk of further disease. The development of oncovirus vaccines holds great promise for reducing cancer burden. Many unanswered questions about the host and environmental cofactors that contribute to cancer development and prevention remain, which ongoing research is attempting to address.
Staying on the democratic script? A deep learning analysis of the speechmaking of U.S. presidents
Authors: Cavari Amnon , Mate Akos , Sebők Miklós 
Published: April 2024

AbstractDynamic agenda representation assumes a linkage between the policy emphases prescribed by various democratic inputs (electoral promises and public opinion polls) and policy agendas ranging from the media to executive orders. An extrapolation of this idea would propose that, in the U.S. context, policy emphasis in major programmatic messages such as State of the Union addresses would be followed by the president's day‐to‐day communication. We investigate this congruence with a new database of presidential speeches that, for the first time, offers a deep learning‐enhanced sentence‐level policy topic coding of various forms of the speeches U.S. presidents made from Truman to Trump (for a total count of 16,523 speeches divided into nearly 2 million individual sentences). Using this database, we demonstrate that presidents' occasional, day‐to‐day remarks strongly correlate with the annual policy messages—in this sense, presidents are staying on the democratic script.
The extrastriate symmetry response is robust to alcohol intoxication
Authors: Karakashevska Elena , Derpsch Yiovanna , Jones Andrew , Makin Alexis D. J. 
Published: April 2024

AbstractVisual symmetry activates a network of regions in the extrastriate cortex and generates an event‐related potential (ERP) called the sustained posterior negativity (SPN). Previous work has found that the SPN is robust to experimental manipulations of task, spatial attention, and memory load. In the current study, we investigated whether the SPN is also robust to alcohol‐induced changes in mental state. A pilot experiment (N = 13) found that alcohol unexpectedly increased SPN amplitude. We followed this unexpected result with two new experiments on separate groups, using an alcohol challenge paradigm. One group completed an Oddball discrimination task (N = 26). Another group completed a Regularity discrimination task (N = 26). In both groups, participants consumed a medium dose of alcohol (0.65 g/kg body weight) and a placebo drink, in separate sessions. Alcohol reduced SPN amplitude in the Oddball task (contrary to the pilot results) but had no effect on SPN amplitude in the Regularity task. In contrast, the N1 wave was consistently dampened by alcohol in all experiments. Exploratory analysis indicated that the inconsistent effect of alcohol on SPN amplitude may be partly explained by individual differences in alcohol use. Alcohol reduced the SPN in light drinkers and increased it in heavier drinkers. Despite remaining questions, the results highlight the automaticity of symmetry processing. Symmetry still produces a large SPN response, even when participants are intoxicated, and even when symmetry is not task relevant.
Should HLA and HPA‐matched platelet transfusions for patients with Glanzmann Thrombasthenia or Bernard‐Soulier syndrome be standardized care? A Dutch survey and recommendations
Authors: Huisman Elise J. , Holle Nory , Schipperus Martin , Cnossen Marjon H. , de Haas Masja , Porcelijn Leendert , Zwaginga Jaap‐Jan 
Published: April 2024

AbstractBackgroundGlanzmann thrombasthenia (GT) and Bernard‐Soulier syndrome (BSS) patients require frequent platelet transfusions and hence have an increased risk for alloimmunization against donor Human Leukocyte Antigens (HLA) when no HLA‐matching is performed. Knowing that Human Platelet Antigens (HPA) are located on the platelet glycoproteins that can be absent in these patients, preventive HPA‐matching may also be considered. Uniform recommendations on this topic lack in transfusion guidelines making standard practice unclear, therefore, we aimed to provide a framework for matched platelet transfusions.Study Design and MethodsWe conducted a targeted literature search and a national survey of Dutch (pediatric) hematologists from July to September 2021.ResultsWe found 20 articles describing platelet transfusion policies in 483 GT‐patients and 29 BSS‐patients, both adults and children. Twenty surveys were returned for full analysis. All responders treated patients with platelet disorders, including GT (n = 36 reported) and BSS (n = 29 reported). Of respondents, 75% estimated the risk of antibody formation as “likely” for HLA and 65% for HPA. Formation of HLA antibodies was reported in 5 GT and in 5 BSS‐patients, including one child. Fifteen respondents gave preventive HLA‐matched platelets in elective setting (75%). Three respondents additionally matched for HPA in GT‐patients (15%). Main argument for matched platelet transfusions was preventing alloimmunization to safeguard the effectivity of ‘random’ donor‐platelets in acute settings.ConclusionElective HLA‐matching for GT and BSS‐patients is already conducted by most Dutch (pediatric) hematologists. HPA‐matching is mainly applied when HPA‐antibodies are formed. Based on the current literature and the survey, recommendations are proposed.
Spectral changes in skin blood flow during pressure manipulations or sympathetic stimulation
Authors: Lima Natalia S. , Tzen Yi‐Ting , Clifford Philip S. 
Published: April 2024

AbstractSkin blood flow is commonly determined by laser Doppler flowmetry (LDF). It has been suggested that pathophysiological conditions can be assessed by analysis of specific frequency domains of the LDF signals. We tested whether physiological stimuli that activate myogenic and neurogenic mechanisms would affect relevant portions of the laser Doppler spectrum. LDF sensors were placed on the right forearm of 14 healthy volunteers for myogenic (six females) and 13 for neurogenic challenge (five females). Myogenic responses were tested by positioning the arm ∼50° above/below heart level. Neurogenic responses were tested by immersing the left hand into an ice slurry with and without topical application of local anaesthetic. Short‐time Fourier analyses were computed over the range of 0.06 to 0.15 Hz for myogenic and 0.02 to 0.06 Hz for neurogenic. No significant differences in spectral density were observed (P = 0.40) in the myogenic range with arm above (7 ± 54 × 10−4 dB) and below heart (7 ± 14 × 10−4 dB). Neurogenic spectral density showed no significant increase from baseline to cold pressor test (0.0017 ± 0.0013 and 0.0038 ± 0.0039 dB; P = 0.087, effect size 0.47). After application of anaesthetic, neurogenic spectral density was unchanged between the baseline and cold pressor test (0.0014 ± 0.0025 and 0.0006 ± 0.0005 dB; P = 0.173). These results suggest that changes in the myogenic and neurogenic spectral density of LDF signals did not fully reflect the skin vascular function activated by pressure manipulation and sympathetic stimulation. Therefore, LDF myogenic and neurogenic spectral density data should be interpreted with caution.
Network model of skeletal muscle cell signalling predicts differential responses to endurance and resistance exercise training
Authors: Fowler Annabelle , Knaus Katherine R. , Khuu Stephanie , Khalilimeybodi Ali , Schenk Simon , Ward Samuel R. , Fry Andrew C. , Rangamani Padmini , McCulloch Andrew D. 
Published: April 2024

AbstractExercise‐induced muscle adaptations vary based on exercise modality and intensity. We constructed a signalling network model from 87 published studies of human or rodent skeletal muscle cell responses to endurance or resistance exercise in vivo or simulated exercise in vitro. The network comprises 259 signalling interactions between 120 nodes, representing eight membrane receptors and eight canonical signalling pathways regulating 14 transcriptional regulators, 28 target genes and 12 exercise‐induced phenotypes. Using this network, we formulated a logic‐based ordinary differential equation model predicting time‐dependent molecular and phenotypic alterations following acute endurance and resistance exercises. Compared with nine independent studies, the model accurately predicted 18/21 (85%) acute responses to resistance exercise and 12/16 (75%) acute responses to endurance exercise. Detailed sensitivity analysis of differential phenotypic responses to resistance and endurance training showed that, in the model, exercise regulates cell growth and protein synthesis primarily by signalling via mechanistic target of rapamycin, which is activated by Akt and inhibited in endurance exercise by AMP‐activated protein kinase. Endurance exercise preferentially activates inflammation via reactive oxygen species and nuclear factor κB signalling. Furthermore, the expected preferential activation of mitochondrial biogenesis by endurance exercise was counterbalanced in the model by protein kinase C in response to resistance training. This model provides a new tool for investigating cross‐talk between skeletal muscle signalling pathways activated by endurance and resistance exercise, and the mechanisms of interactions such as the interference effects of endurance training on resistance exercise outcomes.
Spin Pumping from Lu3Fe5O12
Authors: Volkov D. A. , Gabrielyan D. A. , Matveev A. A. , Safin A. R. , Kalyabin D. V. , Khafizov A. A. , Markelova M. N. , Kaul’ A. R. , Nikitov S. A. 
Published: April 2024

Microwave spin pumping from ferromagnetic lutetium iron garnet (Lu3Fe5O12) has been theoretically and experimentally investigated. The magnetization vector precession excited by a microwave magnetic field is transformed into a dc voltage due to the inverse spin Hall effect in the lutetium iron garnet/heavy metal heterostructure (Lu3Fe5O12/Pt). In the experiments carried out, the external magnetic field has been varied from 0 to 6 kOe, thus making it possible to tune the resonant frequency in wide ranges. The experimental sensitivity of this heterostructure is 8.2 µV/W. A change in the dc voltage sign with a change in the magnetic field direction confirms the generation of spin current in the Lu3Fe5O12/Pt heterostructure. The results obtained make a significant contribution to insight into spin pumping physics and may be useful for the development of new highly sensitive tunable spintronic devices.
A Study of the Effect of Magnetic Scattering on the Analysis of the Nanostructure of Oxide Dispersion-Strengthened Steels by Small-Angle Neutron Scattering
Authors: Rogozhkin S. V. , Klauz A. V. , Gorshkova Yu. E. , Bokuchava G. D. , Khomich A. A. , Bogachev A. A. , Nikitin A. A. , Almásy L. , Kopitsa G. P. 
Published: April 2024

Abstract
A distinctive feature of oxide dispersion-strengthened alloys and steels, which provides a significant increase in heat resistance in comparison with traditional materials, is a significant number of homogeneously distributed nanoscale inclusions (oxides and clusters). For detailed characterization of such materials, a set of techniques is used, such as transmission electron microscopy, atom probe tomography, as well as small-angle scattering of X-rays and neutrons. The latter techniques make it possible to analyze the largest volume of material, while maintaining the ability to detect various nanoscale features. Since ferritic-martensitic oxide dispersion-strengthened steels are ferromagnetic materials, magnetic scattering has to be taken into account in the processing of small-angle neutron scattering data. The nanostructure of ferritic-martensitic oxide dispersion-strengthened steels with different alloying systems (different content of Cr, V, W, Al, and Zr) is investigated by small-angle neutron scattering. A comparison of the results of the study of the nanostructure of steels (oxide particles and clusters) in the ferromagnetic state with and without magnetic scattering is carried out. It is shown that oxide particles have a significantly higher magnetic contrast in comparison with nanoscale clusters. At the same time, the most accurate hardness values can be obtained by taking into consideration of both oxide inclusions and clusters.
Development of a scoring system to quantify errors from semantic characteristics in incident reports
Authors: Uematsu Haruhiro , Uemura Masakazu , Kurihara Masaru , Yamamoto Hiroo , Umemura Tomomi , Kitano Fumimasa , Hiramatsu Mariko , Nagao Yoshimasa 
Published: April 2024

ObjectivesIncident reporting systems are widely used to identify risks and enable organisational learning. Free-text descriptions contain important information about factors associated with incidents. This study aimed to develop error scores by extracting information about the presence of error factors in incidents using an original decision-making model that partly relies on natural language processing techniques.MethodsWe retrospectively analysed free-text data from reports of incidents between January 2012 and December 2022 from Nagoya University Hospital, Japan. The sample data were randomly allocated to equal-sized training and validation datasets. We conducted morphological analysis on free text to segment terms from sentences in the training dataset. We calculated error scores for terms, individual reports and reports from staff groups according to report volume size and compared these with conventional classifications by patient safety experts. We also calculated accuracy, recall, precision and F-score values from the proposed ‘report error score’.ResultsOverall, 114 013 reports were included. We calculated 36 131 ‘term error scores’ from the 57 006 reports in the training dataset. There was a significant difference in error scores between reports of incidents categorised by experts as arising from errors (p<0.001,d=0.73 (large)) and other incidents. The accuracy, recall, precision and F-score values were 0.8, 0.82, 0.85 and 0.84, respectively. Group error scores were positively associated with expert ratings (correlation coefficient, 0.66; 95% CI 0.54 to 0.75, p<0.001) for all departments.ConclusionOur error scoring system could provide insights to improve patient safety using aggregated incident report data.
Are there lost opportunities in chronic kidney disease? A region-wide cohort study
Authors: Sundström Johan , Norhammar Anna , Karayiannides Stelios , Bodegård Johan , Gustafsson Stefan , Cars Thomas , Eriksson Svensson Maria , Ärnlöv Johan 
Published: April 2024

ObjectivesIdentify the windows of opportunity for the diagnosis of chronic kidney disease (CKD) and the prevention of its adverse outcomes and quantify the potential population gains of such prevention.Design and settingObservational, population-wide study of residents in the Stockholm and Skåne regions of Sweden between 1 January 2015 and 31 December 2020.ParticipantsAll patients who did not yet have a diagnosis of CKD in healthcare but had CKD according to laboratory measurements of CKD biomarkers available in electronic health records.Outcome measuresWe assessed the proportions of the patient population that received a subsequent diagnosis of CKD in healthcare, that used guideline-directed pharmacological therapy (statins, renin-angiotensin aldosterone system inhibitors (RAASi) and/or sodium-glucose cotransporter-2 inhibitors (SGLT2i)) and that experienced adverse outcomes (all-cause mortality, cardiovascular mortality or major adverse cardiovascular events (MACE)). The potential to prevent adverse outcomes in CKD was assessed using simulations of guideline-directed pharmacological therapy in untreated subsets of the study population.ResultsWe identified 99 382 patients with undiagnosed CKD during the study period. Only 33% of those received a subsequent diagnosis of CKD in healthcare after 5 years. The proportion that used statins or RAASi was of similar size to the proportion that didn’t, regardless of how advanced their CKD was. The use of SGLT2i was negligible. In simulations of optimal treatment, 22% of the 21 870 deaths, 27% of the 14 310 cardiovascular deaths and 39% of the 22 224 MACE could have been avoided if every patient who did not use an indicated medication for their laboratory-confirmed CKD was treated with guideline-directed pharmacological therapy for CKD.ConclusionsWhile we noted underdiagnosis and undertreatment of CKD in this large contemporary population, we also identified a substantial realisable potential to improve CKD outcomes and reduce its burden by treating patients early with guideline-directed pharmacological therapy.
Assessing the choice of smoke-free policies for multiunit housing and its associated determinants in Bangladesh: a cross-sectional study
Authors: Kibria Md Golam , Islam Taslima , Badiuzzaman Muhammad , Mamun Abdullah Al , Sultana Papia , Hawlader Mohammad Delwer Hossain 
Published: April 2024

ObjectivesThis study aimed to assess the desire for smoke-free housing, determine the choice of smoke-free policies for multiunit housing (MUH), and identify the factors associated with policy choice among MUH residents in Bangladesh.DesignWe conducted a cross-sectional study from April to November 2019 using a semi-structured survey questionnaire.SettingThis study was conducted in seven divisional cities of Bangladesh: Dhaka, Chattogram, Rajshahi, Khulna, Sylhet, Barishal, and Rangpur.ParticipantsA total of 616 adult individuals living in MUH for at least 2 years participated in the study.Primary outcome measureMultinomial logistic regression was used to identify the determinants of the choice of smoke-free policies for MUH.ResultsOverall, 94.8% of the respondents wanted smoke-free housing. Among those who wanted smoke-free housing, 44.9% preferred a smoke-free building policy, 28.3% preferred a smoke-free common area policy, 20.2% favoured a smoke-free unit policy, and 6.7% did not know what policy they should choose. Three factors were found to be significantly associated with the choice of a smoke-free building policy: staying at home for more than 12 hours (adjusted OR (aOR): 2.6; 95% CI 1.035 to 6.493), being a non-smoker (aOR: 3.2; 95% CI 1.317 to 7.582), and having at least one family member who smoked (aOR: 3.0; 95% CI 1.058 to 8.422). Results also showed that residents having at least one child under 15 in the family (aOR: 0.3; 95% CI 0.152 to 0.778) were less likely to choose a smoke-free common area policy and that women (aOR: 3.7; 95% CI 1.024 to 13.188) were more likely to choose a smoke-free unit policy.ConclusionsMUH residents in urban Bangladesh highly demanded smoke-free housing. Most residents favoured a smoke-free building policy for MUH. Those who stayed at home for a longer time, were non-smokers, and had smoking family members were more likely to choose this policy.
Time to initiation of antenatal care and its predictors among pregnant women in Ethiopia: a multilevel mixed-effects acceleration failure time model
Authors: Oyato Befekadu Tesfaye , Abasimel Husen Zakir , Tufa Derara Girma , Gesisa Hana Israel , Tsegaye Tewodros Getachew , Awol Mukemil 
Published: April 2024

ObjectiveTo assess the time to initiation of antenatal care (ANC) and its predictors among pregnant women in Ethiopia.DesignRetrospective follow-up study using secondary data from the 2019 Ethiopian Mini-Demographic and Health Survey.Setting and participants2933 women aged 15–49 years who had ANC visits during their current or most recent pregnancy within the 5 years prior to the survey were included in this study. Women who attended prenatal appointments but whose gestational age was unknown at the first prenatal visit were excluded from the study.Outcome measuresParticipants were interviewed about the gestational age in months at which they made the first ANC visit. Multivariable mixed-effects survival regression was fitted to identify factors associated with the time to initiation of ANC.ResultsIn this study, the estimated mean survival time of pregnant women to initiate the first ANC visit in Ethiopia was found to be 6.8 months (95% CI: 6.68, 6.95). Women whose last birth was a caesarean section (adjusted acceleration factor (AAF)=0.75; 95% CI: 0.61, 0.93) and women with higher education (AAF)=0.69; 95% CI: 0.50, 0.95) had a shorter time to initiate ANC early in the first trimester of pregnancy. However, being grand multiparous (AAF=1.31; 95% CI: 1.05, 1.63), being previously in a union (AAF=1.47; 95% CI: 1.07, 2.00), having a home birth (AAF=1.35; 95% CI: 1.13, 1.61) and living in a rural area (AAF=1.25; 95% CI: 1.03, 1.52) were the impediments to early ANC initiation.ConclusionWomen in this study area sought their initial ANC far later than what the WHO recommended. Therefore, healthcare providers should collaborate with community health workers to provide home-based care in order to encourage prompt ANC among hard-to-reach populations, such as rural residents and those giving birth at home.
Prehospital identification of intracerebral haemorrhage: a scoping review of early clinical features and portable devices
Authors: Almubayyidh Mohammed , Alghamdi Ibrahim , Parry-Jones Adrian Robert , Jenkins David 
Published: April 2024

IntroductionPrehospital identification of intracerebral haemorrhage (ICH) in suspected stroke cases may enable the initiation of appropriate treatments and facilitate better-informed transport decisions. This scoping review aims to examine the literature to identify early clinical features and portable devices for the detection of ICH in the prehospital setting.MethodsThree databases were searched via Ovid (MEDLINE, EMBASE and CENTRAL) from inception to August 2022 using prespecified search strategies. One reviewer screened all titles, abstracts and full-text articles for eligibility, while a second reviewer independently screened 20% of the literature during each screening stage. Data extracted were tabulated to summarise the key findings.ResultsA total of 6803 articles were screened for eligibility, of which 22 studies were included for analysis. Among them, 15 studies reported on early clinical features, while 7 considered portable devices. Associations between age, sex and comorbidities with the presence of ICH varied across studies. However, most studies reported that patients with ICH exhibited more severe neurological deficits (n=6) and higher blood pressure levels (n=11) at onset compared with other stroke and non-stroke diagnoses. Four technologies were identified for ICH detection: microwave imaging technology, volumetric impedance phase shift spectroscopy, transcranial ultrasound and electroencephalography. Microwave and ultrasound imaging techniques showed promise in distinguishing ICH from other diagnoses.ConclusionThis scoping review has identified potential clinical features for the identification of ICH in suspected stroke patients. However, the considerable heterogeneity among the included studies precludes meta-analysis of available data. Moreover, we have explored portable devices to enhance ICH identification. While these devices have shown promise in detecting ICH, further technological development is required to distinguish between stroke subtypes (ICH vs ischaemic stroke) and non-stroke diagnoses.