bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cerebrospinal fluid proteomic profile of frailty: Results from the PROLIPHYC cohort
Authors: Guillotin Sophie , Fulzele Amit , Vallet Alexandra , de Peredo Anne Gonzalez , Mouton‐Barbosa Emmanuelle , Cestac Philippe , Andrieu Sandrine , Burlet‐Schiltz Odile , Delcourt Nicolas , Schmidt Eric 
Published: May 2024

AbstractFrailty is a clinical state reflecting a decrease in physiological reserve capacities, known to affect numerous biological pathways and is associated with health issues, including neurodegenerative diseases. However, how global protein expression is affected in the central nervous system in frail subject remains underexplored. In this post hoc cross‐sectional biomarker analysis, we included 90 adults (52–85 years) suspected of normal pressure hydrocephalus (NPH) and presenting with markers of neurodegenerative diseases. We investigated the human proteomic profile of cerebrospinal fluid associated with frailty defined by an established cumulated frailty index (FI, average = 0.32), not enriched for neurology clinical features. Using a label‐free quantitative proteomic approach, we identified and quantified 999 proteins of which 13 were positively associated with frailty. Pathway analysis with the top positively frailty‐associated proteins revealed enrichment for proteins related to inflammation and immune response. Among the 60 proteins negatively associated with frailty, functional pathways enriched included neurogenesis, synaptogenesis and neuronal guidance. We constructed a frailty prediction model using ridge regression with 932 standardized proteins. Our results showed that the “proteomic model” could become an equivalent predictor of FI in order to study chronological age. This study represents the first comprehensive exploration of the proteomic profile of frailty within cerebrospinal fluid. It sheds light on the physiopathology of frailty, particularly highlighting processes of neuroinflammation and inhibition of neurogenesis. Our findings unveil a range of biological mechanisms that are dysregulated in frailty, in NPH subjects at risk of neurodegenerative impairment, offering new perspectives on frailty phenotyping and prediction.
Pre‐eruptive intracoronal resorption: A report of two cases treated with Biodentine in mandibular premolars
Authors: Casa‐Herzmann Maximiliano , Álvarez Horacio , Soto‐Valencia Nicole , Silva Emmanuel J. N. L. 
Published: May 2024

AbstractPre‐eruptive intracoronal resorption is a rare dental anomaly marked by a radiolucent area within an unerupted tooth. This report discusses the clinical management of pre‐eruptive intracoronal resorption in two mandibular premolars through vital pulp therapy using Biodentine as a sealant. Emphasising the significance of timely intervention for preserving pulp vitality and the tooth's integrity, the present case report underscores the necessity of vigilant clinical and radiographic monitoring for early detection and appropriate treatment. By presenting effective strategies for managing pre‐eruptive intracoronal resorption, the report contributes to the understanding of this condition and highlights the importance of proactive measures in preserving affected teeth and ensuring favourable long‐term outcomes.
Dupilumab for atopic dermatitis in metastatic cancer
Authors: McClatchy Jessica , Ross Gayle 
Published: May 2024

AbstractWe present a case of a 47‐year‐old male with severe atopic dermatitis and metastatic renal cell carcinoma managed successfully with dupilumab. This case further supports the safety of dupilumab in patients with active malignancy, an area currently with limited data.
Gendering Toxic Contamination: Toxic Risks, Bodies, and Pregnancies in Gold Mining and Coca Farming Communities in the Bajo Cauca Region
Authors: Chiavaroli Chiara 
Published: May 2024

AbstractThis paper investigates women's everyday reproductive struggles in contexts of toxic contamination and the tensions emerging between toxic exposure and care in women's experiences of motherhood. While scientific framings of reproductive disruptions understand social identities as pre‐existing the experience of toxic risks, in this paper I argue that, in toxic territories, the categories of “contaminating” and “contaminated” actors interact with other categories of identity, such as gender and race, shaping social relations. Drawing on 13 months of ethnographic fieldwork conducted in the Bajo Cauca region among gold mining and coca farming communities, I investigate the everyday processes of gendered subject formation that unfold in toxic territories and the emergence of “faulty” gendered identities for rural mothers. Building on scholarship in feminist geography and Latin American feminist science and technology studies, I argue that ineffective forms of integration of gender in the institutional debate on toxic contamination reproduce, rather than challenge, the invisibility of rural women before the state.
Moving from voluntary to mandatory sustainability reporting—Transparency in sustainable development goals (SDG) reporting: An analysis of Germany's largest MNCs
Authors: Donner Eva Katharina , Meißner Annekatrin , Bort Suleika 
Published: May 2024

AbstractA growing number of multinational companies (MNCs) report on their progress toward contributing to the Sustainable Development Goals (SDGs) in their annual reports, yet the amount and quality of the information they disclose varies significantly. The aim of this study is twofold: First, we investigate how transparent MNCs report on their SDG engagement and second, we study how the reported SDG engagement changed over time due to major shifts in sustainability reporting requirements. Using a dataset of the largest German MNCs, we analyze their disclosure of SDG contribution reporting practices. Our results show that, overall, between 2016 and 2021 all German MNCs increased their SDG reporting activity and that the MNCs adopted four different practices to report their SDG engagement. We also found that the largest MNCs were more transparent and systematic in their SDG reporting than smaller MNCs, whose reporting was more heterogeneous. Our study contributes to legitimacy research and the role of transparency in corporate reporting as well as the debates on the efficacy of sustainability reporting legislation in the context of SDG engagement. Our findings imply that regulations on environmental and social regulation increase the transparency of sustainability reporting.
Hard to reach, or struggling to be heard? Real‐life experience of coproduction with people with learning disabilities
Authors: Dobel‐Ober David , Moloney Paul , Millichap Sarah 
Published: May 2024

AbstractBackgroundCoproduction is a fast‐developing approach to patient involvement. It entails health and social care services users working as equals in partnership with providers and other public institutions to produce novel research and information, usually aimed at the improvement of service planning and delivery.MethodsThis paper presents two real‐life examples of attempted coproduction with a group of men with learning disabilities in England. The first case study concerns the piloting and assessment of a ‘user‐friendly’ version of a local authority's ‘vision statement’. The second explores an attempt to secure funding to develop and evaluate a community intervention with and for people with learning disabilities.FindingsTogether, these portraits capture two important and intertwined problems that afflict the field of coproduction: namely, the drive to create fast results and the challenges of time and resource allocation that service users and professionals face whenever they attempt to coproduce work in a meaningful way.ConclusionsThe paper concludes with some suggestions for how policy and practice might seek to address these issues in the future.
HIF‐1α and adaptor protein LIM and senescent cell antigen‐like domains protein 1 axis promotes tubulointerstitial fibrosis by interacting with vimentin in angiotensin II‐induced hypertension
Authors: Ni Wei‐Jie , Li Zuo‐Lin , Wen Xian‐Li , Ji Jia‐Ling , Liu Hong , Yin Qing , Jiang Liang‐Yun‐Zi , Zhang Yi‐Lin , Wen Yi , Tang Tao‐Tao , Jiang Wei , Lv Lin‐Li , Gan Wei‐Hua , Liu Bi‐Cheng , Wang Bin 
Published: May 2024

Background and PurposeActivation of the renin‐angiotensin system, as a hallmark of hypertension and chronic kidney diseases (CKD) is the key pathophysiological factor contributing to the progression of tubulointerstitial fibrosis. LIM and senescent cell antigen‐like domains protein 1 (LIMS1) plays an essential role in controlling of cell behaviour through the formation of complexes with other proteins. Here, the function and regulation of LIMS1 in angiotensin II (Ang II)‐induced hypertension and tubulointerstitial fibrosis was investigated.Experimental ApproachC57BL/6 mice were treated with Ang II to induce tubulointerstitial fibrosis. Hypoxia‐inducible factor‐1α (HIF‐1α) renal tubular‐specific knockout mice or LIMS1 knockdown AAV was used to investigate their effects on Ang II‐induced renal interstitial fibrosis. In vitro, HIF‐1α or LIMS1 was knocked down or overexpressed in HK2 cells after exposure to Ang II.Key ResultsIncreased expression of tubular LIMS1 was observed in human kidney with hypertensive nephropathy and in murine kidney from Ang II‐induced hypertension model. Tubular‐specific knockdown of LIMS1 ameliorated Ang II‐induced tubulointerstitial fibrosis in mice. Furthermore, we demonstrated that LIMS1 was transcriptionally regulated by HIF‐1α in tubular cells and that tubular HIF‐1α knockout ameliorates LIMS1‐mediated tubulointerstitial fibrosis. In addition, LIMS1 promotes Ang II‐induced tubulointerstitial fibrosis by interacting with vimentin.Conclusion and ImplicationsWe conclude that HIF‐1α transcriptionally regulated LIMS1 plays a central role in Ang II‐induced tubulointerstitial fibrosis through interacting with vimentin. Our finding represents a new insight into the mechanism of Ang II‐induced tubulointerstitial fibrosis and provides a novel therapeutic target for progression of CKD.
Even though active recommendation for HPV vaccination has restarted, Japan's rates have not recovered
Authors: Yagi Asami , Ueda Yutaka , Oka Emiko , Nakagawa Satoshi , Kimura Tadashi , Shimoya Koichiro 
Published: May 2024

AbstractJapan has a particularly critical situation surrounding its collapsed HPV vaccination program for preventing HPV‐caused cervical cancers, a problem exacerbated by the lack of a national immunization database. We have determined the year‐to‐year HPV vaccination uptake by Japanese females and analyzed by birth fiscal year (FY) the monthly number of people receiving initial HPV vaccination. Our analysis covers the period from the start of public subsidies in 2010 to September 2023, using data provided by local governments. We calculated the cumulative number of monthly immunizations for those unimmunized as of April (the beginning of each vaccination year). The monthly number of initial HPV vaccinations was highest in August for every FY from FY 2010 to FY 2023; a second vaccination peak tended to occur in March when the vaccination year ended. The highest number of August vaccinations occurred in FY 2011, followed (in order) by 2012, 2021, 2022, 2023, and 2013. In Japan's ongoing catch‐up vaccination program for young women, the monthly number of vaccinations increased in August 2022 but then slowed the following year. After FY 2021, the cumulative vaccination coverage of subjects unvaccinated at the beginning of the vaccination year but subsequently covered by routine immunizations was slightly improved. FY 2021 was when the governmental recommendations for HPV vaccination were resumed. More recent vaccination rates are considerably lower than those in FY 2011–2012 when vaccinations were first fully endorsed. Paralyzing HPV vaccination hesitancy, which began in FY 2013, will linger in Japan in FY 2024.
Neurofibroma with glomus‐like bodies: A novel association—Thoughts about origin
Authors: Patel Riya T. , Rizzo Marissa T. , Guerra Karla C. , Grider Douglas J. 
Published: May 2024

AbstractA neurofibroma with focal glomus‐like body differentiation is an unusual phenomenon recently encountered in an excision specimen from the right lateral distal forearm of a 26‐year‐old man. Glomus cells are modified smooth muscle cells normally present in glomus‐like bodies but can also be found in glomus tumors (GT) or lesions considered in the spectrum of GT, including myopericytoma, myofibroma, and angiolipoma. Neurofibromas are peripheral nerve sheath tumors derived from the neural crest cells. While both GT and its variants and neurofibroma are thought to be derived from different cell types, there is growing evidence that glomus cells have a neural crest origin. This is based on multiple theories, with some overlapping pathways, including neural crest cell differentiation, Schwann cell reprogramming, VEGF expression, and NF1 gene biallelic inactivation. This report adds to the growing evidence of possible neural crest origin for glomus cells and would help explain finding glomus‐like bodies scattered through a neurofibroma.
Participação em casa e fatores pessoais e ambientais em crianças e adolescentes com síndrome de Down
Authors: Brugnaro Beatriz Helena , Fernandes Gesica , De Campos Ana Carolina , Pavão Silvia Letícia , Pfeifer Luzia Iara , De Camargo Olaf Kraus , Hlyva Oksana , Rocha Nelci Adriana Cicuto Ferreira 
Published: May 2024

ResumoObjetivoDescrever a participação em casa atual (frequência, envolvimento) e o desejo do cuidador por mudança na participação em casa de crianças e adolescentes com síndrome de Down, bem como fatores ambientais da casa, e explorar as associações de fatores pessoais e ambientais com a participação atual e o desejo do cuidador por mudança.MétodoOitenta e dois cuidadores (média de idade = 45 anos e 10 meses) de crianças e adolescentes com síndrome de Down (média de idade = 10 anos e 7 meses) foram entrevistados sobre a participação em casa da criança e fatores ambientais utilizando a Medida de Participação e do Ambiente ‐ Crianças e Jovens. Além disso, foram coletados fatores pessoais e ambientais das crianças. Os resultados são relatados por meio de análise descritiva e correlações (coeficientes de correlação de Spearman ou teste U de Mann–Whitney) para descrever a relação entre a participação atual e o desejo do cuidador por mudança, com fatores pessoais e ambientais, para as variáveis ordinais e nominais, respectivamente (p < 0,05).ResultadosA participação das crianças foi maior em cuidados pessoais e menor em atividades relacionadas à escola. A maioria dos cuidadores desejava mudança nas lições de casa e nas tarefas domésticas. Maior frequência de participação foi associada ao sexo masculino, distanciamento social menos rigoroso do cuidador devido à pandemia de covid‐19 e crianças recebendo terapia. O maior envolvimento na participação foi associado a uma idade mais jovem nas crianças e a um maior apoio do ambiente. A idade mais avançada das crianças foi associada ao maior desejo por mudança do cuidador.InterpretaçãoFatores pessoais e ambientais são correlacionados com a participação de formas específicas. Devem ser realizadas estratégias criativas para promover a participação e que considerem os desejos do cuidador.
Adenosine kinase inhibits β‐cell proliferation by upregulating DNA methyltransferase 3A expression
Authors: Chen Ting , Yu Jiayu , Guo Xin , Wang Siqi , Wang Zhihua , Chen Yang , Hu Xiang , Li Huiqing , Chen Lulu , Zheng Juan 
Published: May 2024

AbstractAimTo investigate the effects of adenosine kinase (ADK), a key enzyme in determining intracellular adenosine levels, on β cells, and their underlying mechanism.MethodsGenetic animal models and transgenic immortalized cells were applied to study the effect of ADK on islet beta‐cell proliferation and function. The beta‐cell mass and response to glucose were measured in vivo using mice with beta‐cell‐specific ADK overexpression, and in vitro using ADK‐overexpressed immortalized beta‐cell.ResultsThe expression of ADK in human islets at high abundance, especially in β cells, was decreased during the process of β‐cell proliferation. Additionally, a transgenic mouse model (ADKtg/tg /Mip‐Cre) was generated wherein the mouse Insulin1 gene promoter specifically overexpressed ADK in pancreatic β cells. The ADKtg/tg /Mip‐Cre model exhibited impaired glucose tolerance, decreased fasting plasma insulin, loss of β‐cell mass, and inhibited β‐cell proliferation. Proteomic analysis revealed that ADK overexpression inhibited the expression of several proteins that promote cell proliferation and insulin secretion. Upregulating ADK in the β‐cell line inhibited the expression of β‐cell related regulatory molecules, including FoxO1, Appl1, Pxn, Pdx‐1, Creb and Slc16a3. Subsequent in vitro experiments indicated that the inhibition of β‐cell proliferation and the decreased expression of Pdx‐1, Creb and Slc16a3 were rescued by DNA methyltransferase 3A (DNMT3A) knockdown in β cells.ConclusionIn this study, we found that the overexpression of ADK decreased the expression of several genes that regulate β cells, resulting in the inhibition of β‐cell proliferation and dysfunction by upregulating the expression of DNMT3A.
Detecting and managing the patient with chronic kidney disease in primary care: A review of the latest guidelines
Authors: Mayne Kaitlin J. , Hanlon Peter , Lees Jennifer S. 
Published: May 2024

AbstractChronic kidney disease (CKD) is a major global health problem, affecting about 9.5% of the population and 850 million people worldwide. In primary care, most CKD is caused by diabetes and/or hypertension, but a substantial proportion of cases may have alternative causes. During the early stages, CKD is asymptomatic, and many people are unaware that they are living with the disease. Despite the lack of symptoms, CKD is associated with elevated risks of cardiovascular disease, progressive kidney disease, kidney failure and premature mortality. Risk reduction strategies are effective and cost‐effective but require early diagnosis through testing of the estimated glomerular filtration rate and albuminuria in high‐risk populations. Once diagnosed, the treatment of CKD centres around lifestyle interventions, blood pressure and glycaemic control, and preventative treatments for cardiovascular disease and kidney disease progression. Most patients with CKD should be managed with statins, renin‐angiotensin‐aldosterone system inhibitors and sodium‐glucose cotransporter‐2 inhibitors. Additional treatment options to reduce cardiorenal risk are available in patients with diabetes, including glucagon‐like peptide‐1 receptor agonists and non‐steroidal mineralocorticoid receptor antagonists. The Kidney Failure Risk Equation is a new tool that can support the identification of patients at high risk of progressive kidney disease and kidney failure and can be used to guide referrals to nephrology. This review summarizes the latest guidance relevant to managing adults with, or at risk of, CKD and provides practical advice for managing patients with CKD in primary care.
Gastric emptying in newly diagnosed, treatment‐naïve Han Chinese with type 2 diabetes and the impact of 4‐week insulin pump therapy
Authors: Sun Yixuan , Luo Yong , Xiang Chunjie , Xie Cong , Huang Weikun , Sun Zilin , Jones Karen L. , Horowitz Michael , Rayner Christopher K. , Ma Jianhua , Wu Tongzhi 
Published: May 2024

AbstractAimTo evaluate gastric emptying (GE) and the glycaemic response to a 75‐g oral glucose load in newly diagnosed, treatment‐naïve Han Chinese with type 2 diabetes (T2D) before insulin pump therapy, after 4 weeks of insulin pump therapy, and 12–15 months after insulin pump therapy.Materials and MethodsTwenty participants with T2D (baseline glycated haemoglobin [± SD] 10.7% [± 1.2%] 93 [± 10] mmol/mol) ingested a 75‐g glucose drink containing 150 mg 13C‐acetate, to determine the gastric half‐emptying time, and underwent assessment of plasma glucose and serum insulin, C‐peptide and glucagon‐like peptide‐1 (GLP‐1) over 180 min before and after 4 weeks of insulin pump therapy (discontinued for 48 h before re‐assessment). Data were compared to those in 19 healthy participants matched for sex and age. After 12–15 months, GE was re‐measured in 14 of the T2D participants.ResultsAt baseline, participants with T2D exhibited substantially augmented fasting and post‐glucose glycaemia, diminished insulin secretion, and more rapid GE (p < 0.05 each), but comparable GLP‐1, compared to healthy participants. Following insulin pump therapy, insulin secretion increased, GLP‐1 secretion was attenuated, fasting and post‐glucose glycaemia were lower, and GE was slowed (p < 0.05 each). The slowing of GE in T2D participants was sustained over 12–15 months of follow‐up.ConclusionsIn newly diagnosed Han Chinese with T2D, GE is often accelerated despite poor glycaemic control and is slowed by short‐term insulin pump therapy. The effect on GE is maintained for at least 12 months.
Gastric emptying is slower in women than men with type 2 diabetes and impacts on postprandial glycaemia
Authors: Xiang Chunjie , Sun Yixuan , Luo Yong , Xie Cong , Huang Weikun , Jones Karen L. , Horowitz Michael , Sun Zilin , Rayner Christopher K. , Ma Jianhua , Wu Tongzhi 
Published: May 2024

AbstractAimTo evaluate sex differences in gastric emptying and the glycaemic response to a glucose drink and a high carbohydrate meal in type 2 diabetes (T2D).MethodsIn cohort 1, 70 newly diagnosed, treatment‐naïve Chinese patients with T2D (44 men) recruited from a diabetes outpatient clinic ingested a 75‐g glucose drink containing 150 mg 13C‐acetate. In cohort 2, 101 Australian patients with T2D (67 male) recruited from the community, managed by diet and/or metformin monotherapy, ingested a semi‐solid mashed potato meal, labelled with 100 μl 13C‐octanoic acid. Breath samples were collected over 3 and 4 h, respectively, for assessment of gastric emptying, and venous blood was sampled for evaluation of glycaemia (with and without adjustment for each participant's estimated total blood volume).ResultsGastric emptying was slower in female than male subjects in both cohorts (both p < .01). Multiple linear regression analyses revealed that gastric emptying was independently associated with sex (both p < .05). Without adjustment for blood volume, the glycaemic responses to oral glucose and the mixed meal were greater in female subjects (both p < .001). However, after adjustment for blood volume, the glycaemic responses were greater in men (both p < .05).ConclusionsGastric emptying is slower in women than men with T2D, associated with a reduced blood volume‐adjusted glycaemic response to oral glucose and a mixed meal in women. These observations highlight the sex difference in postprandial glucose handling, which is relevant to the personalized management of postprandial glycaemia in T2D.