bluuebunny/crossref_metadata_2025_split huggingface dataset:
Reactions of Cationic Gold(I) with Allenoates: Synthesis of Stable Organogold(I) Complexes and Mechanistic Investigations on Gold‐Catalyzed Cyclizations
Authors: Liu Le‐Ping , Hammond Gerald B. 
Published: May 2009

AbstractThe reaction of allenoates with cationic gold(I)—generated in situ from a phosphine gold chloride and a silver salt—formed unusual, room temperature stable vinyl gold(I) lactones under very mild conditions. The scope and limitations for the synthesis of this novel organogold complex was investigated. DFT calculations on the highest occupied molecular orbitals (HOMOs) of allenoates and the natural bond orbital (NBO) charge densities provided an explanation for the limitations. A plausible mechanism for its formation was proposed based on in situ 1H and 31P NMR spectroscopic analyses. Controlled experiments for the cleavage of the gold–carbon bond by electrophiles indicated that this vinyl gold(I) complex is the likely intermediate in the gold‐catalyzed reaction of carbon–carbon multiple bonds.
The cytoplasmic structure hypothesis for ribosome assembly, vertical inheritance, and phylogeny
Authors: Thaler David S. 
Published: May 2009

AbstractFundamental questions in evolution concern deep divisions in the living world and verticalversushorizontal information transfer. Two contrasting views are: (i) three superkingdoms Archaea, Eubacteria, and Eukarya based on vertical inheritance of genes encoding ribosomes;versus(ii) a prokaryotic/eukaryotic dichotomy with unconstrained horizontal gene transfer (HGT) among prokaryotes. Vertical inheritance implies continuity of cytoplasmic and structural information whereas HGT transfers only DNA. By hypothesis, HGT of the translation machinery is constrained by interaction between new ribosomal gene products and vertically inherited cytoplasmic structure made largely of preexisting ribosomes. Ribosomes differentially enhance the assembly of new ribosomes made from closely related genes and inhibit the assembly of products from more distal genes. This hypothesis suggests experiments for synthetic biology: the ability of synthetic genomes to “boot,”i.e., establish hereditary continuity, will be constrained by the phylogenetic closeness of the cell “body” into which genomes are placed.
Omega‐3 polyunsaturated fatty acids and human health outcomes
Authors: Calder Philip C. , Yaqoob Parveen 
Published: May 2009

AbstractCurrent intakes of very long chain ω‐3 fatty acids, eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA) are low in most individuals living in Western countries. A good natural source of these fatty acids is seafood, especially oily fish. Fish oil capsules contain these fatty acids too. Very long chain ω‐3 fatty acids are readily incorporated from capsules into transport, functional, and storage pools. This incorporation is dose‐dependent and follows a kinetic pattern that is characteristic for each pool. At sufficient levels of incorporation, EPA and DHA influence the physical nature of cell membranes and membrane protein‐mediated responses, eicosanoid generation, cell signaling and gene expression in many different cell types. Through these mechanisms, EPA and DHA influence cell and tissue physiology, and the way cells and tissues respond to external signals. In most cases, the effects seen are compatible with improvements in disease biomarker profiles or in health‐related outcomes. As a result, very long chain ω‐3 fatty acids play a role in achieving optimal health and in protection against disease. Long chain ω‐3 fatty acids protect against cardiovascular morbidity and mortality, and might be beneficial in rheumatoid arthritis, inflammatory bowel diseases, childhood learning, and behavior, and adult psychiatric and neurodegenerative illnesses. DHA has an important structural role in the eye and brain, and its supply early in life is known to be of vital importance. On the basis of the recognized health improvements brought about by long chain ω‐3 fatty acids, recommendations have been made to increase their intake. © 2009 International Union of Biochemistry and Molecular Biology, Inc.
The value of vitalism and Schrodinger's What is Life? in the contemporary classroom
Authors: Sitaraman Ramakrishnan 
Published: May 2009

AbstractClassic experiments and novel ideas in the history of science are often mentioned in passing in contemporary college‐level science curricula. This study indicates that the detailed and creative recapitulation of a few well‐chosen and famous, if well‐known, results and ideas has the potential to increase students' understanding and appreciation of the scientific method and provides them with an altogether novel perspective of science. Since the students are usually aware of the salient facts involved, they are free to concentrate on the method, rather than worry about assimilating new facts. Such an approach has the potential to promote original thinking and rekindle enthusiasm for science, even at the university level.
Pulsatilla decoction and its active ingredients inhibit secretion of NO, ET‐1, TNF‐α, and IL‐1α in LPS‐induced rat intestinal microvascular endothelial cells
Authors: Hu Yiyi , Chen Xi , Duan Huiqin , Hu Yuanliang , Mu Xiang 
Published: May 2009

AbstractTo investigate the pharmacological mechanism of the traditional Chinese medicine, Pulsatilla decoction (PD), the levels of nitric oxide (NO), endothelin‐1 (ET‐1), tumor necrosis factor‐α (TNF‐α), and interleukin‐1α (IL‐1α) secreted by cultured rat intestinal microvascular endothelial cells (RIMECs) were determined after treatment with PD and its seven active ingredients, namely anemoside B4, anemonin, berberine, jatrorrhizine, palmatine, aesculin, and esculetin. RIMECs were challenged with lipopolysaccharide (LPS) at 1 µg ml−1 for 3 h and then treated with PD at 1, 5, and 10 mg ml−1 and its seven ingredients at 1, 5, and 10 µg ml−1 for 21 h, respectively. The results revealed that PD, anemonin, berberine, and esculetin inhibited the production of NO; PD, anemonin, and esculetin inhibited the secretion of ET‐1; PD, anemoside B4, berberine, jatrorrhizine, and aesculin downregulated TNF‐α expression; PD, anemoside B4, berberine, and palmatine decreased the content of IL‐1α. It showed that PD and its active ingredients could significantly inhibit the secretion of NO, ET‐1, TNF‐α, and IL‐1α in LPS‐induced RIMECs and suggested they would reduce inflammatory response via these cytokines. Copyright © 2009 John Wiley & Sons, Ltd.
Improvement of Yarrowia lipolytica Lipase Enantioselectivity by Using Mutagenesis Targeted to the Substrate Binding Site
Authors: Bordes F. , Cambon E. , Dossat‐Létisse V. , André I. , Croux C. , Nicaud J. M. , Marty A. 
Published: June 2009

AbstractEnhanced enantioselectivity: The resolution of 2‐bromo‐arylacetic acid esters by Lip2p lipase from Yarrowia lipolytica was improved through mutagenesis of the substrate binding site. Position 232 was identified as crucial for the discrimination. Saturation of this position led to the identification of variant V232S, which has a tremendously increased activity and E value as compared to the parental enzyme.magnified imageLip2p lipase from Yarrowia lipolytica was shown to be an efficient catalyst for the resolution of 2‐bromo‐arylacetic acid esters, an important class of chemical intermediates in the pharmaceutical industry. Enantioselectivity of this lipase was improved by site‐directed mutagenesis targeted to the substrate binding site. To guide mutagenesis experiments, the three‐dimensional model of this lipase was built by homology modelling techniques by using the structures of lipases from Rhizomucor miehei and Thermomyces lanuginosa as templates. On the basis of this structural model, five amino acid residues (T88, V94, D97, V232, V285) that form the hydrophobic substrate binding site of the lipase were selected for site‐directed mutagenesis. Position 232 was identified as crucial for the discrimination between enantiomers. Variant V232A displayed an enantioselectivity enhanced by one order of magnitude, whereas variant V232L exhibited a selectivity inversion. To further explore the diversity, position 232 was systematically replaced by the 19 possible amino acids. Screening of this library led to the identification of the V232S variant, which has a tremendously increased E value compared to the parental enzyme for the resolution of 2‐bromo‐phenylacetic acid ethyl ester (58‐fold) and 2‐bromo‐o‐tolylacetic acid ethyl ester (16‐fold). In addition to the gain in enantioselectivity, a remarkable increase in velocity was observed (eightfold increase) for both substrates.
ChemInform Abstract: Room Temperature Ferromagnetism in Fe‐Doped BaSnO3.
Authors: Balamurugan K. , Kumar N. Harish , Chelvane J. Arout , Santhosh P. N. 
Published: May 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis of Fe3O4 Nanoparticles at 100 °C and Its Magnetic Characterization.
Authors: Ozkaya Tevhide , Toprak Muhammet S. , Baykal Abdulhadi , Kavas Hueseyin , Koeseoglu Yueksel , Aktas Bekir 
Published: May 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Asymmetric Michael Addition Mediated by Novel Cinchona Alkaloid‐Derived Bifunctional Catalysts Containing Sulfonamides.
Authors: Luo Jie , Xu Li‐Wen , Hay Robyn Aik Siew , Lu Yixin 
Published: May 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Facile, High Regio‐ and Chemoselective Conversion of Epoxides to β‐Chlorohydrins Using Chlorodiphenylphosphine under Solvent‐Free Conditions.
Authors: Aghapour Ghasem , Afzali Asieh , Salek Fahimeh 
Published: May 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: A Facile Method for the Preparation of MOM‐Protected Carbamates.
Authors: Barnes David M. , Barkalow Jufang , Plata Daniel J. 
Published: May 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Aluminum Bases for the Highly Chemoselective Preparation of Aryl and Heteroaryl Aluminum Compounds.
Authors: Wunderlich Stefan H. , Knochel Paul 
Published: May 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Iron‐Catalyzed Ligand‐Free Three‐Component Coupling Reactions of Aldehydes, Terminal Alkynes, and Amines.
Authors: Li Pinhua , Zhang Yicheng , Wang Lei 
Published: May 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: High ortho Preference in Ni‐Catalyzed Cross‐Coupling of Halophenols with Alkyl Grignard Reagents.
Authors: Wang Jia‐Rui , Manabe Kei 
Published: May 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Highly Enantioselective Vinyl Additions of Vinylaluminum to Ketones Catalyzed by a Titanium(IV) Catalyst of (S)‐BINOL.
Authors: Biradar Deepak Baburao , Gau Han‐Mou 
Published: May 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Efficient Asymmetric Transfer Hydrogenation of Ketones Catalyzed by an Iron Complex Containing a P—N—N—P Tetradentate Ligand Formed by Template Synthesis.
Authors: Mikhailine Alexandre , Lough Alan J. , Morris Robert H. 
Published: May 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Ni(0)‐Catalyzed Conjugate Addition of Me3SiCN to Ynones: α‐Bromo‐β‐cyano Tetrasubstituted Enones.
Authors: Arai Takayoshi , Suemitsu Yuuki , Ikematsu Yui 
Published: May 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Enantioselective Organocatalytic Michael Addition of Malonates to α,β‐Unsaturated Ketones.
Authors: Li Pengfei , Wen Shigang , Yu Feng , Liu Qiaoxia , Li Wenjun , Wang Yongcan , Liang Xinmiao , Ye Jinxing 
Published: May 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Desulfurization of Thioamides into Amides with H2O2/ZrCl4 Reagent System.
Authors: Bahrami Kiumars , Khodaei Mohammad Mehdi , Tirandaz Yeganeh 
Published: May 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis and Plant Growth Regulatory Activity of o‐Nitrobenzoylthiourea Derivatives.
Authors: Lin Qi , Yao Hong , Wei Tai‐Bao , Zhang You‐Ming 
Published: May 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: ZrOCl2 Catalyzed Baeyer Condensation: A Facile and Efficient Synthesis of Triarylmethanes under Solvent‐Free Conditions.
Authors: Reddy Ch. Sanjeeva , Nagaraj A. , Srinivas A. , Reddy G. Purnachandra 
Published: May 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Praseodymium‐Induced Pinacol Formation.
Authors: Drapo Jeanette R. , Priefer Ronny 
Published: May 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Ligand‐Free Silver(I)‐Catalyzed Intramolecular Friedel—Crafts Alkylation of Arenes with Allylic Alcohols.
Authors: Bandini Marco , Eichholzer Astrid , Kotrusz Peter , Tragni Michele , Troisi Stefano , Umani‐Ronchi Achille 
Published: May 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Ring Contraction of 1,2‐Dihydronaphthalenes Promoted by Thallium(III) in Acetonitrile: A Diastereoselective Approach to Indans.
Authors: Ferraz Helena M. C. , Carneiro Vania M. T. , Silva Luiz F. Jr. 
Published: May 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: 3‐Aryltetronic Acids: Efficient Preparation and Use as Precursors for Vulpinic Acids.
Authors: Mallinger Aurelia , Le Gall Thierry , Mioskowski Charles 
Published: May 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Benzofurans as Efficient Dienophiles in Normal Electron Demand [4 + 2] Cycloadditions.
Authors: Chopin Nathalie , Gerard Helene , Chataigner Isabelle , Piettre Serge R. 
Published: May 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: An Efficient Synthesis of Raloxifene (VIII) in Ionic Liquid: A Green Approach.
Authors: Shinde Pravin S. , Shinde Sandip S. , Renge Atul S. , Patil Gajanan H. , Rode Ambadas B. , Pawar Rajendra R. 
Published: May 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Enantioselective Zirconium‐Catalyzed Friedel—Crafts Alkylation of Pyrrole with Trifluoromethyl Ketones.
Authors: Blay Gonzalo , Fernandez Isabel , Monleon Alicia , Pedro Jose R. , Vila Carlos 
Published: May 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Base Catalyzed Intramolecular Cyclization of Dialkylcrotyl(3‐alkenylpropyn‐2‐yl)ammonium Salts and Aqueous Base Fission of 2,2‐Dialkyl‐4‐methyl‐ and 2,2‐Dialkyl‐4,6‐dimethyl‐2,6,7,7a‐tetrahydro‐1H‐isoindolium Bromides.
Authors: Chukhajian E. O. , Nalbandyan M. K. , Gevorkyan A. R. , Shakhatuni K. G. , Panosyan G. A. 
Published: May 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: A Conceptually New Approach to the Asymmetric Synthesis of 3‐Aryl and Alkyl Poly‐Substituted Isoindolinones.
Authors: Deniau Eric , Couture Axel , Grandclaudon Pierre 
Published: May 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis and Antimicrobial Activities os Some N‐{4‐[5‐Aryl‐1‐(isonicotinoyl)pyrazol‐3‐yl]‐phenyl}‐benzenesulfonamide and 3‐(4‐Benzenesulfonylaminophenyl)‐5‐aryl‐pyrazole‐1‐carboxylic Acid Amide.
Authors: Jamode V. S. , Chandak H. S. , Bhagat P. R. 
Published: May 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: A Short and Efficient Synthesis of the Selective H4 Receptor Agonist 4‐Methylhistamine.
Authors: Rivara Mirko , Zuliani Valentina , Plazzi Pier V. , Bordi Fabrizio 
Published: May 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Copper‐Facilitated Suzuki Reactions: Application to 2‐Heterocyclic Boronates.
Authors: Deng James Z. , Paone Daniel V. , Ginnetti Anthony T. , Kurihara Hideki , Dreher Spencer D. , Weissman Steven A. , Stauffer Shaun R. , Burgey Christopher S. 
Published: May 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis of 4‐Hydroxy‐3‐formylideneamno‐1H/methyl/phenylquinolin‐2‐ones.
Authors: Bhudevi B. , Ramana P. Venkata , Mudiraj Anwita , Reddy A. Ram 
Published: May 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: 4‐Hydroxy‐2‐quinolones. Part 145. p‐Toluenesulfonylhydrazide as a Tosylating Agent.
Authors: Ukrainets I. V. , Tkach A. A. , Kravtsova V. V. , Shishkina S. V. 
Published: May 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.