bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hyperactive putamen in patients with paroxysmal kinesigenic choreoathetosis: A resting‐state functional magnetic resonance imaging study
Authors: Zhou Bo , Chen Qin , Zhang Qin , Chen Lei , Gong Qiyong , Shang Huifang , Tang Hehan , Zhou Dong 
Published: May 2010

AbstractParoxysmal kinesigenic choreoathetosis (PKC) is a rare neurologic disorder characterized by sudden attacks of brief involuntary dyskinetic movement, which are precipitated by voluntary movement. The pathophysiology of PKC remains unclear. The purpose of this study is to localize cerebral functional abnormalities in idiopathic PKC with resting‐state functional magnetic resonance imaging (fMRI). From May 2007 to August 2008, seven patients with idiopathic PKC were included. The mean age of onset was 11.7 ± 3.1 (range, 8–17) years and the mean disease duration was 6.9 ± 5.1 (range, 1–14) years. Seven subjects of an age‐ and sex‐matched control group were recruited. Interictal brain fMRI was performed in the PKC patients and in the normal controls. Voxel‐based analysis was used to characterize the alteration of amplitude of low frequency fluctuation (ALFF) in patients with PKC. Difference between the patient patterns and the control was analyzed with Student t‐test. The whole brain analysis indicated that the patient group had significantly increased ALFF in the bilateral putamen (P < 0.005) than normal control. fMRI could be useful to evaluate PKC with negative conventional imaging. It was suggested that abnormal cortico‐striato‐pallido‐thalamic loop might be associated with the pathophysiology of idiopathic PKC. © 2010 Movement Disorder Society
Communicating uncertainty in hydro‐meteorological forecasts: mission impossible?
Authors: Ramos Maria‐Helena , Mathevet Thibault , Thielen Jutta , Pappenberger Florian 
Published: May 2010

AbstractThere is a common agreement in the scientific community that communicating uncertain hydro‐meteorological forecasts to water managers, civil protection authorities and other stakeholders is far from being a resolved issue. This paper focuses on the communication of uncertain hydrological forecasts to decision‐makers such as operational hydrologists and water managers in charge of flood warning and scenario‐based reservoir operation. Results from case studies conducted together with flood forecasting experts in Europe and operational forecasters from the hydroelectric sector in France are presented. They illustrate some key issues on dealing with probabilistic hydro‐meteorological forecasts and communicating uncertainty in operational flood forecasting. Copyright © 2010 Royal Meteorological Society
Salvage of SIEA flaps using the retrograde internal mammary system
Authors: Agarwal Jayant P. , Ley Eleazar , Tieman Josh 
Published: May 2010

AbstractSuperficial inferior epigastric artery (SIEA) flaps are ideal for breast reconstruction when the anatomy permits it. Due to the peripheral and superficial location of the pedicle, these flaps can be complicated by vessel kinking against the remaining ribs after insetting. Here, we describe a novel method for SIEA flap salvage after kinking or avulsion of the traditional anastomosis to the internal mammary vessels. © 2010 Wiley‐Liss, Inc. Microsurgery 30:545–548, 2010.
‘tieredScreen’ – Layered Virtual Screening Tool for the Identification of Novel Estrogen Receptor Alpha Modulators
Authors: Yang Yidong , Carta Giorgio , Peters Martin B. , Price Trevor , O'Boyle Niamh , Knox Andrew J. S. , Fayne Darren , Williams D. Clive , Meegan Mary J. , Lloyd David G. 
Published: May 2010

AbstractA novel tiered Structure‐Based (SB) Virtual Screening (VS) workflow called tieredScreen was designed and implemented. The automated protocol utilises diverse computational tools in a synergistic manner to reduce false positives and increase the likelihood of converging on putative active molecules. The performance of the novel VS workflow was validated using the Directory of Useful Decoys (DUD) Estrogen Receptor α (ERα) antagonist dataset, and successfully deployed for the identification of novel antagonists of ERα from a screening collection of ca. 160 000 commercially available compounds. As well as yielding nanomolar (nM) active ligands identified previously through a docking only protocol, from a selection of eight virtual hits suggested by tieredScreen, four novel nM ERα binding chemotypes were identified and biologically validated – demonstrating the applicability of a tiered intervention for virtual screening.
Synthesis and NMR spectral assignments of indol‐3‐yl pyridines through one‐pot multi‐component reaction
Authors: Thirumurugan Prakasam , Nandakumar A. , Vidhya Lakshmi Neelakandan , Phani Kumar B. V. N. , Perumal Paramasivan T. 
Published: May 2010

AbstractAsimple protocol for the efficient preparation of 6‐(ferrocene‐1‐yl)‐2‐(indol‐3‐yl)pyridine and 2‐(1H‐indol‐3‐yl)‐6‐(2‐thienyl)pyridine derivatives has been achieved through multi‐component reaction, and these compounds were thoroughly characterised by 2D NMR spectral techniques. Copyright © 2010 John Wiley & Sons, Ltd.
QRS prolongation in myotonic muscular dystrophy and diffuse fibrosis on cardiac magnetic resonance
Authors: Nazarian Saman , Bluemke David A. , Wagner Kathryn R. , Zviman Menekhem M. , Turkbey Evrim , Caffo Brian S. , Shehata Monda , Edwards David , Butcher Barbara , Calkins Hugh , Berger Ronald D. , Halperin Henry R. , Tomaselli Gordon F. 
Published: May 2010

AbstractCurrent noninvasive surrogates of cardiac involvement in myotonic muscular dystrophy have low positive predictive value for sudden death. We hypothesized that the cardiac MR signal‐to‐noise ratio variance (SNRV) is a surrogate of the spatial heterogeneity of myocardial fibrosis and correlates with electrocardiography changes in myotonic muscular dystrophy. The SNRV for contrast enhanced cardiac MR images was calculated over the entire left ventricle in 43 patients with myotonic muscular dystrophy. All patients underwent standard electrocardiography, and a subset of 23 patients underwent signal averaged electrocardiography. After correcting for body mass index, age, and ejection fraction, SNRV was predictive of QRS duration on standard electrocardiography (1.35‐msec increased QRS duration/unit increase in SNRV, P < 0.001). SNRV was also predictive of the low‐amplitude late‐potential duration (1.49‐msec increased low‐amplitude late‐potential duration/unit increase in SNRV, P < 0.001). Ten‐fold cross‐validation yielded an area under the receiver operating characteristic curve of 0.87 for the predictive value of SNRV for QRS duration greater than 120 msec. The SNRV of the left ventricle is associated with QRS prolongation, likely due to late depolarization of tissue within islands of patchy fibrosis. The association of SNRV with future clinical events warrants further study. Magn Reson Med, 2010. © 2010 Wiley‐Liss, Inc.
Tracer kinetic analysis of dynamic contrast‐enhanced MRI and CT bladder cancer data: A preliminary comparison to assess the magnitude of water exchange effects
Authors: Bains Lauren J. , McGrath Deirdre M. , Naish Josephine H. , Cheung Susan , Watson Yvonne , Taylor M. Ben , Logue John P. , M. Parker Geoffrey J. , Waterton John C. , Buckley David L. 
Published: May 2010

AbstractThe purpose of this study was to determine the impact of water exchange on tracer kinetic parameter estimates derived from T1‐weighted dynamic contrast‐enhanced (DCE)‐MRI data using a direct quantitative comparison with DCE‐CT. Data were acquired from 12 patients with bladder cancer who underwent DCE‐CT followed by DCE‐MRI within a week. A two‐compartment tracer kinetic model was fitted to the CT data, and two versions of the same model with modifications to account for the fast exchange and no exchange limits of water exchange were fitted to the MR data. The two‐compartment tracer kinetic model provided estimates of the fractional plasma volume (vp), the extravascular extracellular space fraction (ve), plasma perfusion (Fp), and the microvascular permeability surface area product. Our findings suggest that DCE‐CT is an appropriate reference for DCE‐MRI in bladder cancers as the only significant difference found between CT and MR parameter estimates were the no exchange limit estimates of vp (P = 0.002). These results suggest that although water exchange between the intracellular and extravascular‐extracellular space has a negligible effect on DCE‐MRI, vascular–extravascular‐extracellular space water exchange may be more important. Magn Reson Med, 2010. © 2010 Wiley‐Liss, Inc.
A fast hierarchical dual boundary element method for three‐dimensional elastodynamic crack problems
Authors: Benedetti I. , Aliabadi M. H. 
Published: May 2010

AbstractIn this work a fast solver for large‐scale three‐dimensional elastodynamic crack problems is presented, implemented, and tested. The dual boundary element method in the Laplace transform domain is used for the accurate dynamic analysis of cracked bodies. The fast solution procedure is based on the use of hierarchical matrices for the representation of the collocation matrix for each computed value of the Laplace parameter. An ACA (adaptive cross approximation) algorithm is used for the population of the low rank blocks and its performance at varying Laplace parameters is investigated. A preconditioned GMRES is used for the solution of the resulting algebraic system of equations. The preconditioners are built exploiting the hierarchical arithmetic and taking full advantage of the hierarchical format. An original strategy, based on the computation of some local preconditioners only, is presented and tested to further speed up the overall analysis. The reported numerical results demonstrate the effectiveness of the technique for both uncracked and cracked solids and show significant reductions in terms of both memory storage and computational time. Copyright © 2010 John Wiley & Sons, Ltd.
Dual Grid Lattice Boltzmann method for multiphase flows
Authors: Rosales C. , Whyte D. S. 
Published: May 2010

AbstractWe present a new methodology for implementing multiphase flow solvers using the Lattice Boltzmann method. Two grids of different size are used to discretize the momentum and the order parameter so that derivatives of the latter (responsible for the forcing terms at the interfaces) are calculated with high accuracy while maintaining a moderate computational cost. We apply the technique to two recently proposed formulations of the multiphase Lattice Boltzmann method, and show that this technique produces significant improvements over a homogeneous mesh refinement in both cases. Copyright © 2010 John Wiley & Sons, Ltd.
Layerwise zig‐zag model with selective refinement across the thickness
Authors: Icardi U. , Ferrero L. 
Published: May 2010

AbstractIn this paper a multilayered model with a hierarchic representation of displacements is developed. The representation, which is based on Jacobi polynomials, can be different for any computational layer, from point to point across the thickness and for any functional d.o.f., aimed at adapting the model to the local variations of solutions. This refinement is obtained by keeping the number of d.o.f. unchanged. The displacements are described through a zig‐zag representation in any computational layer, in order to fulfil the stress contact conditions at the inner interfaces. A displacement‐based version of the model with the six displacement components at the upper and lower faces as functional d.o.f. and a mixed version with the six interlayer stress components are developed. The numerical results mainly concern simply supported thick sandwich beams under sinusoidal loading, but results are also presented for thin cantilevered sandwich beams and laminated plates. The model accurately predicts displacements and stress fields using a single computational layer, even when material properties abruptly change. The computational effort for the adaptive representation is advantageous by the viewpoint with respect to a fixed representation or with the use of post‐processing methods. Copyright © 2010 John Wiley & Sons, Ltd.
Using the clustered circular layout as an informative method for visualizing protein–protein interaction networks
Authors: Fung David C. Y. , Wilkins Marc R. , Hart David , Hong Seok‐Hee 
Published: May 2010

AbstractThe force‐directed layout is commonly used in computer‐generated visualizations of protein–protein interaction networks. While it is good for providing a visual outline of the protein complexes and their interactions, it has two limitations when used as a visual analysis method. The first is poor reproducibility. Repeated running of the algorithm does not necessarily generate the same layout, therefore, demanding cognitive readaptation on the investigator's part. The second limitation is that it does not explicitly display complementary biological information, e.g. Gene Ontology, other than the protein names or gene symbols. Here, we present an alternative layout called the clustered circular layout. Using the human DNA replication protein–protein interaction network as a case study, we compared the two network layouts for their merits and limitations in supporting visual analysis.
Solvent control on the electron transfer reaction between CoIII(en)2Br(L)2+–Fe(CN) (L = aryl amines) by regression relationships: the PXRD and electrochemical investigations
Authors: Anbalagan K. , Lydia I. S. 
Published: May 2010

AbstractSolvent shell coupled electron transfer (ET) reaction, principally between CoIII(en)2Br(L)2+ and Fe(CN) complexes (L = RC6H4NH2; R = m‐OCH3, p‐F, H, m‐CH3, p‐CH3, p‐OC2H5, and p‐OCH3) in H2O/EtOH binary mixed solvents has been investigated. The cobalt(III)‐aryl amine complexes have been structurally refined by powder X‐ray diffraction (PXRD) data as monoclinic unit cell with a distorted geometry. Cyclic voltammograms of the complexes exhibit CoIII/CoII and CoII/CoI reduction peaks with an indication of participation of electron accepting/donating abilities of RC6H4NH2 in the reduction. The ΔEp (50–580 mV) and Ic/ν½ (0.12–2.83) values differ for the complexes. ET between CoIII(en)2Br(L)2+ and Fe(CN) is due to ion pair, {CoIII(en)2Br(L)2+; Fe(CN)}, formation leading to product via (i) solvent caged ({CoIII…FeII}, restricted mobility due to RC6H4NH2) and (ii) solvent controlled (electron accepting/donating substituent in aryl ligand concertedly alters the equilibrium: reactants ↔ ion pair) mechanisms. Reduction was followed in 0–30% v/v (x2: xEtOH = 0, 0.0159–0.1162) aqueous ethanol solutions at 286, 293, and 300 K. Reaction follows second‐order condition and there is a gradation in rate when x2 = 0–0.1162 representing co‐solvent influence. This tendency is understood in the attainment of equilibrium and the formed compact ion pair. In order to estimate the solvent influence, the rate data were subjected to linear and multiple regression analyses using Ys = Y0 + a1X1 + a2X2 + a3X3…anXn correlation relationship. Copyright © 2010 John Wiley & Sons, Ltd.
Pulmonary hypertension secondary to partial pulmonary venous obstruction in a child with Cantu syndrome
Authors: Kobayashi Daisuke , Cook Amanda L. , Williams Derek A. 
Published: May 2010

AbstractWe report on an African‐American male with Cantu syndrome who required a pericardial window for a significant pericardial effusion in infancy and was subsequently found to have partial pulmonary venous obstruction (PVO) leading to pulmonary hypertension. Measurement of bilateral pulmonary capillary wedge pressures is important to uncover partial PVO. Pediatr Pulmonol. 2010; 45:727–729. © 2010 Wiley‐Liss, Inc.
Utilization of a second caregiver in the care of a child with a tracheostomy in the homecare setting
Authors: Tolomeo Concettina (Tina) , Bazzy‐Asaad Alia 
Published: May 2010

AbstractObjectiveTo safely discharge a child with a tracheostomy tube to home, we require two legal guardians/parents to complete a special training program. However, there are times when two parents/guardians are unavailable or unwilling to be trained. Therefore, the purpose of this study was to evaluate the role of the second caregiver of a child with a tracheostomy tube in the home setting.MethodsA retrospective, descriptive, qualitative, pilot study of a convenience sample of parents of 16 children who were discharged from the hospital with a tracheostomy tube between September 2004 and December 2008 was conducted. Data were obtained from the unit's discharge database and from the primary and/or secondary caregivers. Univariate analyses were used to determine the frequency of primary and secondary caregiver participation at home. Themes were generated from caregiver responses regarding utilization of a second caregiver in the home.ResultsA majority (93.8%, n = 15) reported primary caregivers participating very often in the care of the infant at home; less than half (31.3%, n = 5) reported comparable secondary caregiver participation. Fifty percent (n = 8) said they would not be able to care for the infant at home without another trained caregiver. Analysis of the caregiver responses revealed three major themes: confidence, safety, and respite/support.ConclusionFindings support the importance of training two caregivers in the care of a child being discharged with a tracheostomy tube. Training should include the medical/nursing care of the child as well as anticipatory guidance regarding what to expect and the need for respite services. Pediatr Pulmonol. 2010; 45:656–660. © 2010 Wiley‐Liss, Inc.
“Atypical steroid response” in a pulmonary inflammatory myofibroblastic tumor
Authors: Sacco Oliviero , Gambini Claudio , Gardella Chiara , Tomà Paolo , Rossi Umberto G. , Jasonni Vincenzo , Bush Andrew , Rossi Giovanni A. 
Published: May 2010

AbstractA 6‐year‐old girl was evaluated for the presence of a paratracheal mass with right upper lobe atelectasis due to an endobronchial mass. Bronchoscopic biopsy established a diagnosis of inflammatory myofibroblastic tumor (IMT) and prednisone initially led to a significant reduction of the endobronchial lesion. However, 8 weeks later, when still on prednisone, the mediastinal mass enlarged dramatically. At thoracotomy, a well‐circumscribed, multilobulated mass was partially resected and a diagnosis of IMT confirmed. Immunosuppression by corticosteroids may have favored the rapid progression of this apparently benign, indolent tumor. Pediatr Pulmonol. 2010; 45:721–726. © 2010 Wiley‐Liss, Inc.
Diffuse chondroid malformation of the lung: Cases series of a hitherto undescribed congenital lung disease
Authors: Reix Philippe , Wanin Stéphanie , Dijoud Fréderique , Brouard Jacques , Epaud Ralph , Pracros Jean‐Pierre , Boccon‐Gibod Liliane , Bellon Gabriel 
Published: May 2010

AbstractCongenital chondroid lesions of the lung are rare pathological findings. They are a constant feature of lung malformations such as giant cystic pulmonary chondroid hamartoma, chondroid cystic malformation, and in the “cartilaginous variant” of congenital adenomatoid malformation. All of these present as a large single thoracic mass.We present the cases of three males and two females with hitherto undescribed diffuse chondroid lung disease, all but one of whom had neonatal respiratory distress syndrome with interstitial syndrome on chest radiograph. The pathological findings were similar in all patients, showing large areas of disorganized lung parenchyma containing diffusely distributed mature cartilage islands. With a mean follow‐up of 6 years, all patients had a favorable outcome. This diffuse chondroid lung disease appears to be a new entity whose initial presentation mimicked interstitial lung disease without the usual clinical, radiological, and histological features. We speculate that it could be part of a clinical spectrum between malformative chondroid lung cyst and congenital pulmonary airway malformation. Pediatr Pulmonol. 2010; 45:667–673. © 2010 Wiley‐Liss, Inc.
Balloon dilatation in management of postoperative airway obstruction due to tracheal bronchus associated with right main bronchial stenosis: Emphasizing the role of three‐dimensional computed tomography on preoperative evaluation
Authors: Kuo Shu‐Min , Yang Ming‐Ling , Li Yi‐Ching , Tsao Teng‐Fu , Liu Shu‐Chuan , Chen Fong‐Lin 
Published: May 2010

AbstractThree‐dimensional computed tomography (3D‐CT) not only allows accurate preoperative delineation of the lesions but also provides precise pathomechanic diagnosis for planning the most effective treatment to avoid respiratory compromise. In a 10‐month‐old baby girl, who was ventilator‐dependent after successful correction of double outlet right ventricle (DORV), flexible fiberoptic bronchoscopy (FFB) revealed the new formation of postoperative airway obstruction over the right main bronchus (RMB) and obstructed right tracheal bronchus (RTB). 3D‐CT demonstrated tracheobronchial obstruction (TBO) was caused by the dilated ascending aorta (AAo) and right pulmonary artery (RPA). Sequential treatments including artery pexy of AAo and RPA and balloon dilatation (BD) of the stenotic RTB and RMB had successfully restored the airway patency. The patient was successfully weaned from ventilator 2 days after treatments and has shown no respiratory difficulty thus far. Thus, the impact of preoperative 3D‐CT on planning treatment cannot be emphasized. Pediatr Pulmonol. 2010; 45:730–733. © 2010 Wiley‐Liss, Inc.
Adiposity and low‐grade systemic inflammation modulate matrix metalloproteinase‐9 levels in Greek children with sleep apnea
Authors: Kaditis Athanasios G. , Alexopoulos Emmanouel I. , Karathanasi Anastasia , Ntamagka Georgia , Oikonomidi Smaragda , Kiropoulos Theodoros S. , Zintzaras Elias , Gourgoulianis Konstantinos 
Published: May 2010

AbstractBackgroundMatrix metalloproteinase‐9 (MMP‐9) plasma levels correlate with C‐reactive protein (CRP) concentrations and they are both increased in adults with obstructive sleep apnea (OSA). No studies have evaluated MMP‐9 levels in children with sleep apnea and CRP is not consistently elevated in pediatric OSA. The aim of this investigation was to evaluate the association of severity of OSA, adiposity, and CRP with MMP‐9 plasma levels in Greek children.MethodsConsecutive children with snoring who underwent polysomnography and were found to have OSA (obstructive apnea–hypopnea index—OAHI ≥ 1 episode/hr) were recruited. Subjects without OSA (OAHI < 1 episode/hr) were included for comparison. Morning plasma MMP‐9 and CRP were measured.ResultsTwenty‐nine children with moderate‐to‐severe OSA (age 5.4 ± 1.5 years; OAHI 13.9 ± 13.0 episodes/hr), 55 participants with mild OSA (6.4 ± 2.6 years; OAHI 2.4 ± 1.1 episodes/hr) and 22 subjects without OSA (6.8 ± 2.6 years; OAHI 0.6 ± 0.2 episodes/hr) were studied. Children with moderate‐to‐severe OSA were similar to those with mild OSA or without OSA regarding ln‐transformed MMP‐9 values (5.87 ± 0.60 vs. 5.84 ± 0.55 vs. 5.80 ± 0.46; P > 0.05) and CRP concentrations (0.22 ± 0.29 mg/dl vs. 0.21 ± 0.36 vs. 0.13 ± 0.16 mg/dl; P > 0.05). In multiple linear regression, body mass index (P = 0.027) and CRP levels (P = 0.008), but not OAHI or SpO2 nadir (P > 0.05), were significantly related to MMP‐9 values.ConclusionsAdiposity and systemic inflammation unrelated to OSA severity, modulate MMP‐9 levels in Greek children. Pediatr Pulmonol. 2010; 45:693–699. © 2010 Wiley‐Liss, Inc.