bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prescription Data Mining and Network Pharmacology Study of 1152 Patients with Rectal Prolapse using Traditional Chinese Medicine
Authors: Zhang Meng , Tang Shao-liang , Yang Tong-ling , Cheng Yan , Gong Yue 
Published: May 2024

Background:
In recent years, the incidence of rectal prolapse has increased significantly
due to the sedentary lifestyle and irregular eating habits of modern life. However, there is
a lack of clinical studies on the treatment of rectal prolapse with traditional Chinese medicine
(TCM) with a large sample size. Therefore, this study investigated the characteristics of rectal
prolapse treatment formulas and then studied the network pharmacology of their core therapeutic
drugs, which can help to provide a reference for the treatment and postoperative care of rectal
prolapse patients.

Objective:
This study aimed to explore the prescription characteristics and the mechanism of
action of core drugs in the treatment of rectal prolapse in Chinese medicine through data mining
and bioinformatics techniques.

Methods:
We collected the diagnosis and treatment information of patients with rectal prolapse
from January 2014 to September 2021 in the electronic case database of Nanjing Hospital of
TCM, mined the patient information and prescription features using R, screened the active ingredients
of the core pairs of drugs and disease drug intersection targets using TCMSP and
GnenCard databases, and constructed a Protein-protein interaction (PPI) network using
STRING and Cytoscape, and Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes
(KEGG) enrichment analyses of the intersecting targets were performed using Metascape
and R.

Results:
We found that prolapse is easy to occur in people over 50 years old, preferably in autumn
and winter. Commonly used therapeutic Chinese medicines include Glycyrrhiza glabra,
Radix angelicae sinensis, Radix astragali, Atractylodes macrocephala, and Pericarpium citri
reticulatae, which are mostly deficiency tonic medicines, warm in nature, and belong to spleen
meridian. The core therapeutic medicinal pair was “Bupleuri radix-Cimicifugae rhizoma”.
There were 190 common targets of Bupleuri radix and Cimicifugae rhizoma, and 71 intersection
targets of the drug pair and prolapse. The main components of the core drugs for the treatment
of prolapse may be quercetin, kaempferol, Stigmasterol, etc, and the core targets may be
CASP3, AKT1, HIF1A, etc. The total number of GO entries for the intersection targets of “Bupleuri
radix-Cimicifugae rhizoma” and diseases was 3495, among which the molecular functions
accounted for the largest proportion, mainly Pathways in cancer, IL-18 signaling pathway,
etc. KEGG enriched pathway analysis yielded 168 results, and the major pathways were pathways
in cancer, lipid and atherosclerosis, IL-17 signaling pathway, etc.

Conclusion:
This study adopted real-world research methodology and used data mining and
bioinformatics technology to mine the medication law of rectal prolapse and its core drug action
mechanism from the clinical information of Chinese medicine.
Harnessing the Therapeutic Potential of Plants and Plant-Derived
Constituents in Diabetic Neuropathy: Recent Advances and Challenges
Authors: Barbhuiya Sm Abdul Aziz , Dutta Partha Pratim , Barua Chandana Choudhury , Saikia Kalyani , Kakati Ajay 
Published: May 2024

Abstract::
Diabetic Neuropathy (DN) stands as one of the most deleterious consequences of prolonged
hyperglycemia, affecting an estimated 50% of individuals with diabetes during their lifetime.
Despite the prominent role of oxidative stress and inflammatory pathogenesis in DN, its precise etiology
remains elusive. This study explores the recent strides in the field of plant interventions for
DN, shedding light on promising avenues while navigating through existing challenges.
A comprehensive search of the literature was carried out using keywords related to diabetes mellitus,
diabetic peripheral neuropathy, herbal medicine, plant extracts, phytoconstituents, and diabetic complications.
The search was conducted across different reputable scientific databases, including Medline,
Scopus, Google Scholar, PubMed, and others.
It has been observed that the antioxidant properties of plants and plant-derived constituents, especially
the phenolic constituents, coupled with their impact on inflammatory cytokines, opioid receptors,
nerve conduction velocity, and glial activation, exhibited potential in ameliorating impaired nerve
function through modulation of oxidative stress markers. Behavioral parameters, including mechanical
and thermal hyperalgesia, allodynia, and tactile allodynia, demonstrated notable improvement
following the oral administration of these plant interventions in in vivo animal models. Despite the
promising outcomes, challenges persist, encompassing a limited understanding of precise mechanisms,
variability in study designs, and a dearth of robust clinical evidence.
The study underscores the imperative for comprehensive research, standardization, and rigorous clinical
testing to fully unlock the therapeutic potential of herbal interventions in the management of DN.
Determining the Type and Frequency of Prescribed Antibiotics in Patients Admitted to the Infectious Department of Imam Khomeini Hospital in Jiroft, year 2021 (A Cross-Sectional Study)
Authors: Anaeigoudari Akbar , Raesi Rasoul , Heydarian Seyyedeh Mona Taghdisi , Mohammadnahal Leila , Daneshi Salman , Domari Asma Amiri , Jamali Ali , Kargar Shiva 
Published: May 2024

Background
Indiscriminate administration of antibiotics and excessive use of these drugs increase microbial resistance.

Aim
This study aims to investigate the type and frequency of prescribed antibiotics in patients admitted to Imam Khomeini Hospital in Jiroft in 2021.

Methods
In this cross-sectional study, the files of 5100 patients hospitalized in the infectious disease department of Imam Khomeini Hospital in Jiroft were examined. The criteria for inclusion in the study were patients admitted to the infectious disease department of Imam Khomeini Hospital for whom antibiotics were prescribed in the treatment order. The data was collected through a checklist that included demographic information, type of antibiotic used, prescribed dose, season of prescribing, and expertise of the prescriber. Data were analyzed with SPSS software.

Results
The results of the study revealed that the average number of antibiotic items consumed per person in the infectious department of Imam Khomeini Hospital in Jiroft City was 1.95 ± 0.4. Also, the most common antibiotic used in the present study was ceftriaxone, which accounted for more than 70% of the total prescribed antibiotics, and the highest average number of antibiotic items studied per prescription was related to vancomycin. In addition, the highest frequency of prescribed antibiotics was related to the autumn season and was prescribed by an internist.

Conclusion
In this study, ceftriaxone is the most widely used antibiotic in the infectious sector. Also, the highest frequency of prescribed antibiotics was related to the autumn season and prescribed by an internist.
In Silico Analysis of Non-Synonymous Snps in the Human WWOX Gene
Authors: Sidhic Nihala , Subbiah Usha 
Published: May 2024

Aim:
To analyse the nsSNPs associated with the human WWOX gene using
bioinformatics tools.

Background:
WW domain-containing oxidoreductase (WWOX) is a protein-coding gene
that controls several biological processes, including RNA splicing, transcription, and protein
degradation. The modification in the WWOX gene is associated with osteopenia,
metabolic syndrome, gestational diabetes, tumour progression, and disruption in lipid metabolism.

Objective:
The study focused on understanding the structural and functional distribution
of high-risk nsSNPs of the WWOX gene using several bioinformatics tools.

Methods:
Retrieval of nsSNPs of WWOX gene from NCBI and Uniprot database. Identification
of deleterious missense SNPs using the tools SIFT, Polyphen v2, PROVEAN,
FATHMM, PhD-SNP, and SNPs & GO. The gene-gene and protein-protein interactions
were investigated using GeneMANIA and STRING, respectively. The structural and
functional characterisation of the gene was predicted using I-Mutant, MUPro, SOPMA,
Alpha Fold, and NetPhos 3.1.

Results:
The study identified 7 out of 646 nsSNPs (rs193001955, rs200371768,
rs370792938, rs2303192, rs371364838, rs372362643, rs374343152) as deleterious. The
identified nsSNPs were destabilizing the WWOX protein. The secondary structure prediction
indicated that the majority of the nsSNPs were random coil and alpha-helix. Meanwhile,
phosphorylation was observed in several positions in threonine and serine residues,
and the least phosphorylation was observed for tyrosine in the WWOX gene. Phosphorylation
of high-risk variants of this gene may lead to alteration in the regulation of posttranslational
modification.

Conclusion:
Our study predicted 7 functional nsSNPs that had detrimental effects on the
structure and function of the WWOX gene. This will aid in the identification of candidate
deleterious nsSNPs markers as a potential therapeutic target for disease diagnosis.
Nucleobase and Peptide-based Designed Molecules for Biomedical Applications
Authors: Sen Shantanu , Kaul Grace , Verma Sandeep 
Published: May 2024

:
Exploring a diverse range of bioinspired molecules is crucial for addressing real-world healthcare challenges and finding effective solutions. While
numerous materials have been proposed and developed, their compatibility and stability within biological systems remain not fully understood and
they are still undergoing extensive examination for their potential successful therapeutic translation. In this context, we aimed to provide an
overview of bioinspired molecules that incorporate peptide as well as nucleobase-derived frameworks and explore their potential applications in
the field of advanced therapeutics. Unlike many synthetic materials, these scaffolds exhibit remarkable biocompatibility, making them a promising
avenue for addressing these concerns.

:
The increasing demand for alternative biocompatible materials stems from the necessity for therapeutic solutions to address diverse biological
challenges. Therefore, compiling existing technologies may offer a comprehensive resource for researchers in this field.

:
In this review, special attention has been given to bioinspired molecules showcasing a diverse array of therapeutic functions, encompassing
gasotransmitters delivery-mediated neuromodulation, sensing, and detection of important biological analytes, tissue engineering, anti-aggregating
molecules, antibacterial compounds, anti-cancer molecules, etc.

:
This review has comprehensively summarized the design, practicality, and utilization of intriguing nucleobase or peptide-based bioinspired
molecules for their potential advanced therapeutic applications. Significant constraints within current biocompatible materials continue to impede
their potential for clinical translation and functional utilization. Hence, this review may inspire the readers to explore further significant findings in
the field of novel bioinspired molecules’ synthesis and their potential therapeutic applicability.
Nature's Remedy: Exploring Herbal Treatments for Polycystic Ovarian
Syndrome
Authors: Attri Meenakshi , Raghav Asha , Chaudhary Hema 
Published: May 2024

:
Polycystic Ovarian Syndrome (PCOS) is a complex condition characterized by chronic
ovulation issues and hyperandrogenism, affecting approximately 6% to 20% of women of reproductive
age, depending on diagnostic criteria. Symptoms typically manifest during early adolescence,
presenting as irregular menstrual cycles, anovulation, and acne. While some mechanisms
underlying PCOS development have been identified, its precise etiology and pathophysiology
remain elusive.

:
This article delves into the pathogenesis and management of PCOS by exploring relevant literature
on PubMed. Various contributing factors to PCOS were meticulously examined, including
epigenetics, environmental toxins, stress, diet, inflammation, oxidative stress, hyperandrogenism,
insulin resistance, and obesity. This review examines the importance of herbal remedies in
addressing Polycystic Ovarian Syndrome (PCOS), focusing on the chemical makeup, mode of
action, and therapeutic uses of specific herbal medications targeting PCOS. However, despite
this investigation, there remains a significant gap in completed clinical trials on repurposed
drugs for PCOS, often with small sample sizes and inconclusive outcomes. Given the limited
research in this area, further studies and carefully planned clinical trials are warranted to understand
PCOS and its management better. Additionally, gaining deeper insights into PCOS could
facilitate the development of novel drugs targeting newly discovered pathways, thereby improving
treatment options for individuals affected by this syndrome
Identifying Learning Preferences and Strategies in Health Data Science Courses: Systematic Review
Authors: Rohani Narjes , Sowa Stephen , Manataki Areti 
Published: May 2024

Background
Learning and teaching interdisciplinary health data science (HDS) is highly challenging, and despite the growing interest in HDS education, little is known about the learning experiences and preferences of HDS students.

Objective
We conducted a systematic review to identify learning preferences and strategies in the HDS discipline.

Methods
We searched 10 bibliographic databases (PubMed, ACM Digital Library, Web of Science, Cochrane Library, Wiley Online Library, ScienceDirect, SpringerLink, EBSCOhost, ERIC, and IEEE Xplore) from the date of inception until June 2023. We followed the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines and included primary studies written in English that investigated the learning preferences or strategies of students in HDS-related disciplines, such as bioinformatics, at any academic level. Risk of bias was independently assessed by 2 screeners using the Mixed Methods Appraisal Tool, and we used narrative data synthesis to present the study results.

Results
After abstract screening and full-text reviewing of the 849 papers retrieved from the databases, 8 (0.9%) studies, published between 2009 and 2021, were selected for narrative synthesis. The majority of these papers (7/8, 88%) investigated learning preferences, while only 1 (12%) paper studied learning strategies in HDS courses. The systematic review revealed that most HDS learners prefer visual presentations as their primary learning input. In terms of learning process and organization, they mostly tend to follow logical, linear, and sequential steps. Moreover, they focus more on abstract information, rather than detailed and concrete information. Regarding collaboration, HDS students sometimes prefer teamwork, and sometimes they prefer to work alone.

Conclusions
The studies’ quality, assessed using the Mixed Methods Appraisal Tool, ranged between 73% and 100%, indicating excellent quality overall. However, the number of studies in this area is small, and the results of all studies are based on self-reported data. Therefore, more research needs to be conducted to provide insight into HDS education. We provide some suggestions, such as using learning analytics and educational data mining methods, for conducting future research to address gaps in the literature. We also discuss implications for HDS educators, and we make recommendations for HDS course design; for example, we recommend including visual materials, such as diagrams and videos, and offering step-by-step instructions for students.
Mindful Self-Compassion Smartphone Intervention for Worker Mental Health in Japan: Protocol for a Randomized Controlled Trial
Authors: Kurosawa Takumu , Adachi Koichiro , Takizawa Ryu 
Published: May 2024

Background
Mental health problems among workers cause enormous losses to companies in Japan. However, workers have been considered to have limited access to psychological support because of time constraints, which makes it difficult for them to engage in face-to-face psychological support interventions.

Objective
This study aimed to present an intervention protocol that describes a randomized controlled trial to examine whether brief guided mindfulness meditation (MM) or self-compassion meditation (SCM) provided by a smartphone app is effective for mental health and work-related outcomes among workers.

Methods
This is an open-label, 3-arm randomized controlled trial. The participants will be recruited through an open call on relevant websites with the following inclusion criteria: (1) employees who are working more than 20 hours per week, (2) between the ages of 18 and 54 years, (3) not on a leave of absence, (4) not business owners or students, and (5) not currently diagnosed with a mental disorder and have a Kessler Psychological Distress Scale-6 score below 13 points. We will include 200 participants and randomly assign them to an SCM course (n=67), an MM course (n=67), and a waitlist group (n=66). The intervention groups (SCM and MM) will be instructed to engage in daily guided self-help, self-compassion, and MMs lasting 6-12 minutes per day over 4 weeks. Primary outcomes will include psychological distress and job performance, and secondary outcomes will include somatic symptoms, cognitive flexibility, self-esteem, self-compassion, perceived stress, well-being, emotion regulation, work engagement, anger, psychological safety, and creativity. All procedures were approved by the ethics committee of the University of Tokyo (22-326). All participants will be informed of the study via the websites, and written informed consent will be collected via web-based forms.

Results
The recruitment of participants began in December 2022, and the intervention began in January 2023. As of September 2023, a total of 375 participants have been enrolled. The intervention and data collection were completed in late October 2023.

Conclusions
This study will contribute to the development of effective self-care intervention content that will improve mental health, work performance, and related outcomes and promote mindful and self-compassionate attitudes when faced with distress.

Trial Registration
University Hospital Medical Information Network Clinical Trials Registry UMIN000049466; https://tinyurl.com/23x8m8nf

International Registered Report Identifier (IRRID)
DERR1-10.2196/53541
Assessing the Content and Effect of Web-Based Decision Aids for Postmastectomy Breast Reconstruction: Systematic Review and Meta-Analysis of Randomized Controlled Trials
Authors: Yu Lin , Gong Jianmei , Sun Xiaoting , Zang Min , Liu Lei , Yu Shengmiao 
Published: May 2024

Background
Web-based decision aids have been shown to have a positive effect when used to improve the quality of decision-making for women facing postmastectomy breast reconstruction (PMBR). However, the existing findings regarding these interventions are still incongruent, and the overall effect is unclear.

Objective
We aimed to assess the content of web-based decision aids and its impact on decision-related outcomes (ie, decision conflict, decision regret, informed choice, and knowledge), psychological-related outcomes (ie, satisfaction and anxiety), and surgical decision-making in women facing PMBR.

Methods
This systematic review and meta-analysis followed the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines. A total of 6 databases, PubMed, Embase, Cochrane Library, CINAHL, PsycINFO, and Web of Science Core Collection, were searched starting at the time of establishment of the databases to May 2023, and an updated search was conducted on April 1, 2024. MeSH (Medical Subject Headings) terms and text words were used. The Cochrane Risk of Bias Tool for randomized controlled trials was used to assess the risk of bias. The certainty of evidence was assessed using the Grading of Recommendations, Assessment, Development, and Evaluation approach.

Results
In total, 7 studies included 579 women and were published between 2008 and 2023, and the sample size in each study ranged from 26 to 222. The results showed that web-based decision aids used audio and video to present the pros and cons of PMBR versus no PMBR, implants versus flaps, and immediate versus delayed PMBR and the appearance and feel of the PMBR results and the expected recovery time with photographs of actual patients. Web-based decision aids help improve PMBR knowledge, decisional conflict (mean difference [MD]=–5.43, 95% CI –8.87 to –1.99; P=.002), and satisfaction (standardized MD=0.48, 95% CI 0.00 to 0.95; P=.05) but have no effect on informed choice (MD=–2.80, 95% CI –8.54 to 2.94; P=.34), decision regret (MD=–1.55, 95% CI –6.00 to 2.90 P=.49), or anxiety (standardized MD=0.04, 95% CI –0.50 to 0.58; P=.88). The overall Grading of Recommendations, Assessment, Development, and Evaluation quality of the evidence was low.

Conclusions
The findings suggest that the web-based decision aids provide a modern, low-cost, and high dissemination rate effective method to promote the improved quality of decision-making in women undergoing PMBR.

Trial Registration
PROSPERO CRD42023450496; https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=450496
Diagnosis of Feline Panleukopenia Based on Clinical Signs and Polymerase Chain Reaction in Various Ages of Cats
Authors: Ramadhani Mungky Ema , Indarjulianto Soedarmanto , Yanuartono Yanuartono , Raharjo Slamet , Purnamaningsih Hary , Widyarini Sitarina , Milla Yunita Apriana 
Published: May 2024

Feline panleukopenia (FPL) is a viral infectious disease caused by the feline panleukopenia virus (FPV) that affects cats of all ages. Clinical symptoms that appear in each individual cat vary greatly, depending on age, immune status, and the presence or absence of secondary infection. The aim of this research was to diagnose the FPL based on clinical signs and polymerase chain reaction (PCR) in cat with various ages. This study used 15 cats that showed one of clinical symptoms including lethargy, anorexia, fever, diarrhea, and vomiting. All cats were examined physically and by PCR of blood, then analyzed descriptively. The results showed that 10/15 (66.7%) cats were <7 months, 4/15 (26.7%) were 7-12 months, and 1/15 (6.6%) was >1 year old. Identification by PCR showed that 100% of the samples positive, so that all of cats diagnosed FPL. Clinical signs that commonly appeared in this study included anorexia (80%), fever (80%), vomiting (73.3%), lethargy (66.7%), and diarrhea (40%). Young cats <7 months commonly showed anorexia, fever, vomiting, and lethargy, cats aged 7-12 months commonly showed anorexia, fever, vomiting, and diarrhea, cat aged >12 months experienced anorexia and vomiting. Concluded that the predominant clinical symptoms of FPL in young cats were anorexia, fever, vomiting and lethargy, whereas in adult cats anorexia, fever, vomiting, and diarrhea. Clinical symptoms can be used for initial screening of FPL, but the causative diagnosis needs to be determined by polymerase chain reaction.