bluuebunny/crossref_metadata_2025_split huggingface dataset:
Synthesis and anticonvulsant activity of 1‐aryl‐3‐methylene‐2‐pyrrolidinone adducts
Authors: Kornet Milton J. 
Published: April 2009

AbstractReaction of 1‐aryl‐3‐methylene‐2‐pyrrolidinones with several active hydrogen compounds resulted in a Michael addition to give the title compounds. The compounds were screened in the maximal electroshock seizure and subcutaneous pentylenetetrazol seizure threshold tests for anticonvulsant activity and in the rotorod test for neurotoxicity in mice. Several compounds displayed anticonvulsant activity, but only at the high dose levels of 300 or 600 mg/kg.
Synthesis and spectroscopic properties of some new N,N'‐disubstituted thiorueas of potential biological interest
Authors: Sarkis George Y. , Faisal Essam D. 
Published: April 2009

AbstractThirty‐six new N,N'‐disubstituted thioureas have been synthesized by the reaction of phenyl‐, p‐fluorophenyl‐ and benzoylisothiocyanates with various substituted anilines, aminopyridines and 4‐aminoquinolines. The uv, ir and nmr spectral data are presented and discussed.
Studies on 5‐arylidene‐3‐phenyl‐2‐methylmercaptohydantoins
Authors: Kadry Azza M. , Mansour Salwa A. 
Published: April 2009

AbstractThe action of ammonium acetate on 5‐arylidene‐3‐phenyl‐2‐methylmercaptohydantoins 1g,h in acetic acid led to the formation of the 5‐arylidene‐3‐phenylhydantoin derivatives 4a,b. In absence of a solvent, ring opening and rearrangement took place with the formation of the 5‐arylidene‐N2‐phenylglycocyamidine derivatives 7a‐c. Compounds 7a‐c reacted with methyl iodide to afford the corresponding 3‐methyl derivatives 9a‐c. The structures of the synthesised products were established and the mechanism proposed for the rearrangement reaction was discussed.
3‐Alkylthio and 3‐aminopyrazolo[3,4‐D]pyridazines. Ring contraction of pyridazino[4,5‐e][1,3,4]thiadiazines via extrusion of sulfur
Authors: Kaji Kenji , Nagashima Hiromu , Ohhata Yasushi , Tabashi Keizo , Oda Hirohisa 
Published: April 2009

AbstractReaction of 4‐chloro‐2‐methyl‐5‐(1‐methylhydrazino)‐3(2H)‐pyridazinone (1) with carbon disulfide followed by alkylation yielded 2‐alkylthio‐4H‐pyridazino[4,5‐e][1,3,4]thiadiazine derivatives 2. Oxidative cyclization of 5‐(4‐substituted 1‐methylthiosemicarbazido)‐3(2H)‐pyridazinone derivatives 4 with N‐bromosuccinimide also gave 2‐substituted amino‐4H‐pyridazino[4,5‐e][1,3,4]thiadiazine derivatives 5. Heating of 2 and 5 resulted in ring contraction to afford the corresponding pyrazolo[3,4‐d]pyridazine derivatives 6, 7 via sulfur extrusion. A possible mechanism for the desulfurization reaction is discussed, comparing with a structural difference between a type of pyridazino[4,5‐e][1,3,4]thiadiazine (2,5) and another one (9,11,13,15).
P‐N compounds.25. Phosphaminimides.1. Synthesis and bioevaluation of a derivative of tetrahydro‐2H‐1,3,4,2‐oxadiazaphosphorinium inner salt
Authors: Cates Lindley A. , Li Ven‐Shun , Basrur Jyoti P. , Saddawi Bashir H. , Alkadhi Karim A. 
Published: April 2009

Abstract2‐Phenoxy‐4,4‐dimethyltetrahydro‐2H‐1,3,4,2‐oxadiazaphosphorinium 2‐oxide inner salt, the first known cyclic phosphaminimide, was synthesized by dehydroiodination of its hydrazinium salt. The corresponding 2‐phenyl derivative was unstable and not isolated. The 2‐phenoxy and 2‐phenylphosphorinium iodides and their precursors produced weak inhibition of sympathetic ganglionic transmission. The phosphaminimide caused a slight potentiation and was also found to be less toxic than its corresponding hydrazinium iodide precusor.
An alternative synthesis of 3‐amino‐1,2,3,4‐tetrahydrocarbazoles
Authors: Bird C. W. , Wee A. G. H. 
Published: April 2009

Abstract3‐Amino‐1,2,3,4‐tetrahydrocarbazoles are easily prepared from the readily available 3‐hydroxy‐1,2,3,4‐tetrahydrocarbazoles by conversion of the latter to the p‐toluene‐ or methanesulfonate ester, followed by nu‐cleophilic displacement with azide ion. The resulting 3‐azido‐1,2,3,4‐tetrahydrocarbazoles are then catalytically hydrogenated to their 3‐amino counterparts.
Studies on pyrrolidinones. Synthesis of methyl N‐(4‐nitrobenzyl)pyroglutamate
Authors: Rigo Benoǐt , Couturier Daniel 
Published: April 2009

AbstractMethyl N‐trimethylsilylpyroglutamate is reacted with 4‐nitrobenzyl chloride to yield methyl N‐(4‐nitrobenzyl)pyroglutamate.
Synthesis and mass spectral studies of 1‐[5‐chloro‐1‐substituted‐2(1H)‐pyrazin‐2‐on‐3‐yl]‐5‐aryl‐3‐methylpyrazoles
Authors: Bhattacharya B. K. , Eirich F. R. 
Published: April 2009

AbstractSixteen new 1‐[5‐chloro‐1‐substituted‐2(1H)‐pyrazin‐2‐on‐3‐yl]‐5‐aryl‐3‐methylpyrazoles V have been synthesized by condensation of 5‐chloro‐1‐substituted‐3‐hydrazino‐2(1H)‐pyrazin‐2‐ones III and 1‐aryl‐1,3‐butanediones IV in dry 1,4‐dioxane. The general mass spectral fragmentation mode of these compounds has been studied.
Fused‐s‐triazino heterocycles. XII. 13H‐4,6,7,8,13a, 13c‐hexaazabenzo‐[de]naphthacene, a new ring system
Authors: Shaw John T. , Babin James E. , Sensenig Lori A. , Acciai Guy F. , Fair Mark C. , Coffindaffer Timothy W. , Westler W. Milo 
Published: April 2009

AbstractThe synthesis of the titled compound is described using 5‐(2‐carboxyanilino)‐2‐methyl‐1,3‐4,6,9b‐pentaaza‐phenalene as starting material.
(Perhalogenmethylthio)heterocyclen. XVIII . Synthese und eigenschaften von halogenierten (perhalogenmethylthio)pyrrolen
Authors: Ceacareanu Dimitru M. , Gerstenberger Michael R. C. , Haas Alois 
Published: April 2009

Abstract(Trifluormethylthio)pyrrole 1‐5 und (Chlordifluormethylthio)pyrrol 6 lassen sich mit den Chlorierungsmitteln Sulfurylchlorid, Sulfurylchlorid/Siliciumdioxid oder Sulfurylchlorid/Dischwefeldichlorid/Aluminiumtrichlorid in die entsprechenden chlorierten Verbindungen 1a‐d, 2a, b, 3a, b, 4a, 5a und 6a‐c überführen. Die Bromierung mit Brom bzw. Iodierung mit Iod/Kaliumiodid von 2, 3, 4 und 6 liefert die Derivative 2c, d, 3c, d, 4b und 6d bzw. 2e, 3e, f, 4c und 6e. Gemischthalogenierte Pyrrole 3g und h werden aus 3a und Brom bzw. 3a und Iod/Kaliumiodid erhalten. 7, 8 und 9 fallen in geringen Ausbeuten als Nebenprodukte eineger Chlorierungen an.1H‐, 19F‐NMR‐ und IR‐Spektren werden angegeben.
Studies on pyrrolidinones. Synthesis of 5‐(5‐oxo‐2‐pyrrolidinyl)‐1,3,5‐oxadiazole‐2‐thione derivatives
Authors: Rigo Benoî;t , Couturier Daniel 
Published: April 2009

AbstractStarting from readily available pyroglutamic esters 1, some new 1,3,4‐oxadiazole‐2‐thione derivatives, bonded to a pyrrolidinone ring were synthesised and characterised by their spectral data.
Oxidative cyclization of some 1,3‐dioximes with lead tetraacetate
Authors: Stephanidou‐Stephanatou J. 
Published: April 2009

AbstractOxidation of 1,3‐dioximes 1 with lead tetraacetate gives di‐N‐oxides of pyrazolines 4 or pyrazoles 5 or N‐oxides of oxadiazines 7 as the main reaction products. The reaction mechanism is discussed.
Synthesis of 1,3,4‐thiadiazolo[3,2‐α]pyrimidin‐5‐one and isomeric 7‐one derivatives
Authors: Russo Filippo , Santagati Andrea , Santagati Maria 
Published: April 2009

AbstractContinuing preceeding studies, designed to obtain derivatives of 1,3,4‐thiadiazolo[3,2‐α]pyrimidin‐5‐one and of the isomeric 7‐one of pharmacological interest, some of the above mentioned compounds were prepared. Their structural identification was obtained by mass spectra.
A new route to N2‐ and N3‐substituted‐2,3‐diaminopyridines. Synthesis of 1‐ and 3‐alkoxycarbonyl‐v‐triazolo[4,5‐b]pyridines
Authors: Zecchini Giampiero Pagani , Torrini Ines , Paradisi Mario Paglialunga 
Published: April 2009

AbstractSelective protection of the 3‐amino group of 2,3‐diaminopyridine with benzyl chloroformate allows a new synthesis of 3‐methylamino‐ and 3‐amino‐2‐alkylaminopyridines. The preparation of 1‐ and 3‐alkoxycarbonyl‐v‐triazolo[4,5‐b]pyridines is also reported.
Synthesis and mass spectrum of 3‐(3′‐pyridinyloxymethyl)pyridine and polarography of its dialkyl diquaternary salts
Authors: Attalla Moetaz I. , Burnett Geoffrey R. , Summers Lindsay A. 
Published: April 2009

Abstract3‐(3′‐Pyridinyloxymethyl)pyridine is prepared by reaction of 3‐hydroxymethylpyridine with 3‐bromopyridine and converted to the 1,1′‐dimethyl and 1,1′‐diethyl diquaternary salts with alkyl iodides. The salts are reduced polarographically at a potential (Eo) of about ‐ 1.02 to ‐ 1.10 V in the pH range of 5.5‐8.5.
Preparation of 1,2,5‐thiadiazole‐3‐carboxaldehydes
Authors: Matakas Shuntaro , Kurisu Masayoshi , Takahashi Kazufumi , Tashiro Masashi 
Published: April 2009

Abstract1,2,5‐Thiadiazole‐3‐carboxaldehydes 1a‐c were prepared by the acid‐catalyzed decomposition of 3‐azido‐methyl‐1,2,5‐thiadiazoles 2a‐c in 68‐83% yields, respectively. Pyrolysis of 2a and 2b afforded the imidazoles 4a and 4b in low yields. NBS‐bromination of 1a and 1b gave the corresponding carboxylic acids 10a and 10b via acid bromides 9. Azides 2a and 2b gave the s‐triazines 8a and 8b on treatment with NBS.
The preparation and oxidative dimerisation of 2‐acetyl‐7‐hydroxy‐1,2,3,4‐tetrahydroisoquinoline. A new approach to tetrahydroisoquinoline synthesis
Authors: Ajao J. F. , Bird C. W. 
Published: April 2009

AbstractThe title compound has been prepared from 1,2,3,4‐tetrahydroisoquinoline via successive nitration, acet‐ylation, reduction and diazotisation. Earlier conflicting reports on the nitration of tetrahydroisoquinoline have been clarified. A better synthetic route, based upon reduction of the corresponding isocarbostyril, has been devised and should be applicable to the obtention of a wide range of tetrahydroisoquinolines. The structure of the neutral product of oxidative dimerisation of 2‐acetyl‐7‐hydroxy‐1,2,3,4‐tetrahydroisoquinoline has been established.
Synthesis of 5H‐tetrazolo[5,1‐c][1,4]benzodiazepines
Authors: Klaubert Dieter H. , Bell Stanley C. , Pattison Thomas W. 
Published: April 2009

AbstractA three step synthesis of 5H‐tetrazolo[5,1‐c][1,4]benzodiazepin‐11‐ones 8a‐d via the reaction of a substituted benzyl azide and ethyl cyanoformate is described. The derived lactams are converted to the corresponding 11‐thiones 9a‐d and, through the S‐methylated derivatives, to the 11‐amino analogs 11a‐f. All of the described compounds are representatives of a novel ring system.
Synthesis of 2‐substituted 4‐oxo‐5‐nitropyrimidines from methyl 3‐ethoxy‐2‐nitroacrylate and other reactions
Authors: de la Cuesta E. , Avendaño C. 
Published: April 2009

AbstractMethyl 3‐ethoxy‐2‐nitroacrylate (MENA) (1) has been the subject of study for the development of new syntheses leading to nitro‐substituted heterocycles.
Pyrimidines. LII Synthesis of pyrido[2,3‐d]pyrimidine‐2,4‐diones and pyrido[2,3‐d:6,5‐d']dipyrimidine‐2,4,6,8‐tetrones
Authors: Hirota Kosaku , Kitade Yukio , Senda Shigeo 
Published: April 2009

AbstractReactivities of 5‐dimethylaminomethylene‐6‐imino‐1,3‐dimethyluracil hydrochloride (1) toward a variety of active methylene compounds 2 and 5 were investigated. Treatment of 1 with active methylene compounds such as malononitrile and ethyl cyanoacetate in the presence of triethylamine gave pyrido[2,3‐d]pyrimidine‐2,4‐dione derivatives 3. Reaction of 1 with barbituric acids resulted in the formation of pyrido[2,3‐d:6,5‐d′]di‐pyrimidine‐2,4,6,8‐tetrone derivatives 6.
Synthesis of the new ring system, Pyrazolo[3,4‐d][1,3]diazepine. A novel route for the synthesis of azolo[1,3]diazepines
Authors: Acevedo Oscar L. , Krawczyk Steven H. , Townsend Leroy B. 
Published: April 2009

AbstractA reduction of the nitrile group of 5‐amino‐4‐cyano‐1‐methylpyrazole (3) has provided the very versatile compound 5‐amino‐1‐methylpyrazole‐4‐carboxaldehyde (4). The amino group of 4 was protected using di‐methylformamide dimethylacetal and the aldehyde group was then reacted with trimethylsilyl cyanide to afford the moisture sensitive compound 5‐[[(dimethylamino)methylene]amino]‐4‐[cyano(trimethylsiloxy)‐methyl]‐1‐methylpyrazole (10). The cyano group of the cyanohydrin 10 was reduced using a cobalt boride catalyst to afford an intermediate aminomethyl group which was involved in an in situ annulation. This reaction provided 1‐methyl‐1,4,5,6‐tetrahydropyrazolo[3,4‐d][1,3]diazepin‐4‐ol, a derivative of the new ring system, pyrazolo[3,4‐d][1,3]diazepine.
Fries rearrangement of methoxyphenyl 3‐methylbut‐2‐enoates
Authors: Camps F. , Coll J. , Colomina O. , Messeguer A. 
Published: April 2009

AbstractFries rearrangement of 2‐, 3‐ and 4‐methoxyphenyl 3‐methylbut‐2‐enoates 3‐5 in methanesulfonic acid, polyphosphoric acid, aluminum chloride and under photochemical conditions have been studied. The outcome of the reactions was determined by the substitution pattern in the starting products and the reaction conditions used. Under Lewis acid catalysis, acylation accounted for the major components of the reaction mixtures, leading to the formation of indanones and 2,3‐dihydro‐4H‐1‐benzopyran‐4‐ones respectively in the case of o‐ and m‐esters 3 and 5, whereas alkylation to afford dihydrocoumarins was the favored path for p‐ester 5. On the other hand, o‐acylation was in all cases the major reaction course in the photochemical rearrangement.
Pyrido[1,2‐a]benzimidazoles et analogues: Synthese et etude structurale
Authors: Bergerat Isabelle , Galons Hervé , Rabaron Alain , Combet‐Farnoux Claude , Miocque Marcel 
Published: April 2009

AbstractLes (propynyl‐2)‐1 aminométhyl‐2 benzimidazoles, préparés à partir d'orthodiamines aromatiques, peuvent être transformés avec de bons rendements en pyrido[1,2‐a]benzimidazoles. Le premier temps de la réaction est une hétérocyclisation: les intermédiaires ont été isolés et leur réarrangement étudié. La méthode est applicable à certains azabenzimidazoles.
Studies on alkylpyrazine dianions. Preparation of 5,6,11,12‐tetrahydrocycloocta[1,2‐b:5,6‐b']dipyrazine
Authors: Houminer Yoram , Williams David L. 
Published: April 2009

AbstractThe reaction of 1,2‐bis(3‐methyl‐2‐pyrazyl)ethane (1) with two equivalents of LDA followed by 1,2‐dibromo‐ethylene gave a mixture of two intramolecular ring closure products, 2 and 3, in low yields. A dimer 4 resulting from an intermolecular coupling reaction was also isolated.
Saturated heterocycles. 70 . Application of the seth‐paul‐van duyse equation. 10 . The C  O stretching frequencies and transmission of substituent effects in 5,6‐polymethylene‐2,3,5,6‐tetrahydro‐1,3‐oxazin‐4‐one derivatives
Authors: Perjéssy Alexander , Fülöp Ferenc , Bernáth Gábor 
Published: April 2009

AbstractThe C  O stretching frequencies of twenty‐six cis‐5,6‐polymethylene‐2,3,5,6‐tetrahydro‐1,3‐oxazinone derivatives were measured in tetrachloromethane and in chloroform and correlated with the substituent constants X+(R) in the sense of the modified and extended Seth‐Paul Van Duyse equation. The influence of the fused hydrocarbon ring on the C  O stretching frequency and on the transmission of substituent effects through the six‐membered heterocyclic ring is discussed and compared with that in the previously investigated 5,6‐polymethylenepyrimidin‐4(3H)‐ones and cis‐5,6‐dihydropyrimidin‐4(3H)‐ones.
Reaction of 6‐arylidenehydrazino‐1,3‐dimethyluracils with thionyl chloride leading to purine, thiazolo[4,5‐d]pyrimidine, pyrimido[4,5‐e][1,3,4]thiadiazine, pyrazolo[3,4‐d]pyrimidine, and [1,2,3]thiadiazolo[4,5‐d]pyrimidine derivativese
Authors: Ichiba Misuzu , Senga Keitaro 
Published: April 2009

AbstractThe reaction of 6‐arylidenehydrazino‐1,3‐dimethyluracils with thionyl chloride in benzene afforded purine, thiazolo[4,5‐d]pyrimidine, pyrimido[4,5‐e][1,3,4]thiadiazine, pyrazolo[3,4‐d]pyrimidine, and [1,2,3]thiadiazolo[4,5‐d]pyrimidine derivatives, while the treatment of 6‐(benzylidene‐1′‐methylhydrazino)‐1,3‐dimethyluracil with thionyl chloride in benzene gave 4‐methylpyrimido[4,5‐e][1,3,4]thiadiazine and 1‐methylpyrazolo‐[3,4‐d]pyrimidine derivatives. Plausible mechanisms for the formation of these fused pyrimidines are also described.
Synthesis of a novel series of 3‐substituted [1]benzothieno[3,2‐d]pyrimidine derivatives
Authors: El‐Telbany Farag , Hutchins Robert O. 
Published: April 2009

AbstractA series of 3‐substituted [1]benzothieno[3,2‐d]pyrimidine derivatives has been synthesized as possible antileukemic agents by condensation of methyl 3‐(ethoxymethylene)amino‐2‐benzothiophene carboxylate (II) with a variety of amines to afford the corresponding 3‐aryl and 3‐alkyl [I]benzothieno[3,2‐d]pyrimidin‐4(3H)‐ones, Ill and IV, respectively. In addition, Mannich reactions of [I]benzothieno[3,2‐d]pyrimidin‐4(3H)‐one (VIII) with formaldehyde and secondary amines gave the expected derivatives, IX. 3‐Amino[I]benzothieno[3,2‐d]‐pyrimidin‐4(3H)‐one (VI) reacted with substituted aromatic aldehydes in the presence of boron trifluoride to yield the corresponding imines VII.
Reactions of β‐sulfenyl α,β‐unsaturated ketones with guanidine, Amidines, and diamines
Authors: Nishio Takehiko , Tokunaga Tatsuhiro , Omote Yoshimori 
Published: April 2009

Abstractβ‐Sulfenyl α, β‐unsaturated ketones 1a‐c reacted with guanidine or amidines to give pyrimidine derivatives 3 in 14‐76% yields. Treatment of ketones 1 with diamines such as ethylenediamine and o‐phenylenediamine afforded the seven‐membered heterocycles, 2,3‐dihydro‐1,4‐diazepine 5 and 2,3‐benzo‐1,4‐diazepines 8a‐c.
Efficient synthesis of 5‐substituted‐4,5‐dihydro‐1,2,4‐triazin‐6‐ones and 5‐substituted‐1,2,4‐triazin‐6‐ones
Authors: Taylor Edward C. , Macor John E. 
Published: April 2009

AbstractTreatment of methyl α‐(dimethylarninomethyleneamino)carboxylates 1 (from α‐amino acids and dimethylformamide dimethylacetal) with hydrazine gives 5‐substituted‐4,5‐dihydro‐1,2,4‐triazin‐6‐ones 2, which are smoothly dehydrogenated to 5‐substituted‐1,2,4‐triazin‐6‐ones 3 with potassium permanganate in acetone/acetic acid.
Synthesis of novel imidazole‐4,5‐dicarboxylic acid derivatives
Authors: Yasuda Naohiko 
Published: April 2009

AbstractA convenient general method for the synthesis of unsymmetrical imidazole‐4,5‐dicarboxylic acid derivatives is described. The key intermediates are 5,10‐dioxo‐5H,10H‐diimidazo[1,5‐a:1′,5′‐d[pyrazine‐1,6‐dicarboxylic acid, ‐1,6‐dicarboxylic ester and ‐1,6‐dicarboxamide.
Chemical properties of 2‐isopropylimino‐3‐isopropyl‐5‐methoxy‐Δ4‐oxazoline: Formation of charge‐transfer complexes from an oxazoline
Authors: Drapier J. , Badot J. , Jonius L. , Warin R. , Hubert A. J. , Teyssie Ph. 
Published: April 2009

Abstract2‐Isopropylimino‐3‐isopropyl‐5‐methoxy‐Δ4‐oxazoline 1 copolymerizes readily by a radicalar mechanism with maleic anhydride, an air and heat sensitive isolable charge‐transfer monomer 2 being formed as intermediate. Similarly, a (more stable) adduct 4 has been prepared from 1 and TCNE. In opposition, acrylic acid adds onto the Δ4‐oxazoline endocyclic double bond giving the acrylate 5. The hydrolysis and hydrogenation of 1 are also reported.
Synthesis of 5,6‐dihydropyrrolo[l,2‐α][3,1,6]thiadiazocines
Authors: Cheeseman G. W. H. , Hawi A. A. , Varvounis G. 
Published: April 2009

AbstractThe title compounds 15‐18 and 26 are prepared by intramolecular cyclisation of the pyrrolylthiols derived from sodium borohydride reduction of N‐aryl‐thiocyanatopyrroles 11‐14 and 25.
Further reactions of 3‐hydroxy‐1(3H)‐isobenzofuranone with amines
Authors: Sloan Kenneth B. , Koch Suzanne A. M. 
Published: April 2009

AbstractThe reaction of 3‐hydroxy‐1(3H)‐isobenzofuranone (III) with 2‐phenylethylamines has been shown to give either monoalkylated VI or dialkylated VII products (prodrugs) depending on the number of equivalents of III used. The monoalkylated products disproprotionated to the dialkylated products unless they were stabilized as salts. In addition, the reaction of III with cytosine and adenine resulted in the formation of N4 and N6‐alkylated products, respectively. The alkylated 2‐phenylethylamines, and cytosine and adenine are representative of a new type of prodrug approach to modifying the physical chemical properties of these two important classes of drugs.
Chemistry of pyrimidine. Proton magnetic resonance study of covalent hydration across the 3,4‐carbon‐nitrogen bond of 5‐substituted pyrimidines
Authors: Kress Thomas J. 
Published: April 2009

AbstractPyrimidines containing 5‐substituents which are weakly or strongly electron withdrawing undergo covalent hydration across the 3,4‐carbon‐nitrogen bond in aqueous acid. The degree of hydration was measured by proton magnetic resonance spectroscopy and was found to be dependent on the strength of the acid media and the electron withdrawing power of the 5‐substituent.
Mass spectral fragmentations of 6‐phenyl‐5,6,7,8‐tetrahydro‐4H‐1,3,6‐dioxazocin‐2‐ones
Authors: Nishiyama Tomihiro , Maeda Masayuki , Yamada Fukiko 
Published: April 2009

AbstractThe mass spectra of a series of 6‐phenyl‐5,6,7,8‐tetrahydro‐4H‐1,3,6‐dioxazocin‐2‐ones have been examined.
Une nouvelle synthese de β‐enaminoindanones
Authors: Brunerie Pascal , Célérier Jean‐Pierre , Lhommet GÉRard 
Published: April 2009

AbstractLes (3‐énaminoindanones sont préparées en une seule étape à partir de l'‐chlorométhylbenzoate d'éthyle et de différents β‐énaminoesters cycliques ou acycliques, par action de l'hydrure de sodium en suspension dans le toluène.
Synthesis of pyrazolo[3,2‐c]‐1,2,4‐triazines from N‐(5‐pyrazolyl)‐α‐ketohydrazidoyl halides
Authors: Abdelhamid Abdou O. , Hassaneen Hamdi M. , Shawali Ahmad S. 
Published: April 2009

Abstract3‐Phenylpyrazole‐5‐diazonium chloride (5) couples with benzenesulfonylacetone (9a), benzenesulfonylacetophenone (9b), ethyl benzenesulfonylacetate 9c, and ethyl benzoylacetate (12b) in ethanol in the presence of sodium acetate at room temperature to afford the pyrazolo[3,2‐c]‐1,2,4‐triazine derivatives 11a and 11b and the acyclic hydrazones 10c and 13 respectively. The products 11a,b and 10c can also be obtained from the reaction of the corresponding hydrazidoyl halides 8a‐c with sodium benzenesulfinate in high yield. The hydrazones 10c and 13 can be cyclised thermally or under the influence of acid into pyrazolo[3,2‐c]‐1,2,4‐triazine derivatives 11c and 14 respectively.
Novel reactions of carbon suboxide. VI. Synthesis of 2‐Oxo‐1‐benzopyran‐ and 2‐oxoquinoline‐3‐carboxylic acid hydrazides
Authors: Bonsignore Leonardo , Loy Giuseppe , Secci Mario , Cabiddu Salvatore 
Published: April 2009

AbstractA simple, one step synthesis of 2‐oxo‐1‐benzopyran‐ and 2‐oxoquinoline‐3‐carboxylic acid hydrazides from carbon suboxide and hydrazones is described.
The chemistry of 2h‐3,1‐benzoxazine‐2,4(1H)‐dione (isatoic anhydride). 17 Synthesis of 2‐alkyl‐4‐quinolone alkaloids via a one‐step reaction of N‐methylisatoic anhydride with methyl ketone enolates
Authors: Coppola Gary M. 
Published: April 2009

AbstractLithium enolates derived from aliphatic methyl ketones react with N‐methylisatoic anhydride (5) at −78° to give 2‐alkyl‐4‐quinolone alkaloids 7 in a single step. The method was used to synthesize both double bond isomers of 1‐methyl‐2‐(8‐tridecenyl‐4(1H)‐quinolinone (8) thereby showing that the alkaloid evocarpine possesses the Z‐olefin stereochemistry 8a. Reduction of 8a provided the alkaloid dihydroevocarpine (16). Compound 16 was also directly prepared from the reaction of 5 with the lithium enolate of 2‐pentadecanone.
The preparation of phenacylpyrazoles, acylpyrazoles, imidazolylisoxazoles and imidazolylpyrazoles from c(α)‐dianions of oximes, phenylhydrazones and acylhydrazones
Authors: Huff Ann M. , Hall Howard L. , Smith Melanie J. , O'Grady Sheila A. , Waters Frank C. , Fengl Richard W. , Welsh Jeffery A. , Beam Charles F. 
Published: April 2009

AbstractC(α),O‐Dilithiooximes, C(α), N‐dilithiophenylhydrazones, or C(α), N‐dilithioacylhydrazones were prepared in an excess of lithium diisopropylamide (LDA) and condensed with a variety of esters followed by acid‐cyclization to give substituted isoxazoles and pyrazoles.
The 1‐alkoxy‐4‐nitro‐1,2,3‐benzotriazole system
Authors: Maxwell G. , Seybold P. G. , Servé M. P. 
Published: April 2009

AbstractThe 1‐alkoxy‐4‐nitro‐1,2,3‐benzotriazole system was prepared using a phase transfer catalysis procedure. The physical and spectral properties of the system are reported. Molecular orbital calculations on the 1‐methoxy derivative are used to explain the spectroscopic and electronic properties of the system.