bluuebunny/crossref_metadata_2025_split huggingface dataset:
Crop Rotation and Soil Amendment Alters Sorghum Grain Quality
Authors: Mady Kaye Nanga , Mason Stephen C. , Jackson David S. , Galusha Tom D. 
Published: July 2010

ABSTRACTSoybean [Glycine max (L.) Merr.] rotation enhances grain sorghum [Sorghum bicolor (L.) Moench] yield, but influence on grain quality has not been measured. The objective was to determine the effect of cropping sequence (CS) and soil amendment (SA) on grain yield and quality. Sorghum grain yield and quality, soil NO3–N and water were measured in a rotation study in 2003 and 2004 on a Sharpsburg silty clay loam (fine, smectitic, mesic Typic Argiudoll). Cropping sequences were continuous sorghum, and sorghum rotated with non‐nodulating and nodulating soybean. Soil amendments consisted of no amendment, manure (17–26 Mg dry matter ha−1 yr−1), and N (84 kg ha−1 yr−1). CS × SA interaction effects were found for most parameters. Rotation with non‐nodulating soybean without SA increased yield by 2.6 to 2.8 Mg ha−1 over continuous sorghum without SA. Rotation without SA with nodulating soybean further increased yield by 1.7 to 1.8 Mg ha−1 over rotation with non‐nodulating soybean. Grain N increased by 0.5 to 1.0, 2.5 to 5.0, and 3.3 to 4.9 g kg−1 for N application to continuous sorghum and sorghum rotated with non‐nodulating and nodulating soybean, respectively. Tangential abrasive dehulling device (TADD) removal indicated that continuous sorghum without SA produced the softest grain with 43 to 44% TADD removal, and sorghum rotated with nodulating soybean with manure produced the hardest grain with 22 to 27% TADD removal. As food end‐use opportunities for sorghum grain evolve, use of crop rotation and SA application will be important to produce grain with desirable quality attributes.
Map Location of the Rpp1 Locus That Confers Resistance to Soybean Rust in Soybean
Authors: Hyten D. L. , Hartman G. L. , Nelson R. L. , Frederick R. D. , Concibido V. C. , Narvel J. M. , Cregan P. B. 
Published: July 2010

ABSTRACTSoybean rust (SBR), caused by Phakopsora pachyrhizi, was first discovered in North America in 2004 and has the potential to become a major soybean [Glycine max (L.) Merr.] disease in the USA. Currently, four SBR resistance genes have been identified but not mapped on the soybean genetic linkage map. One of these resistance genes is the Rpp1 gene, which is present in the soybean accession PI 200492 The availability of molecular markers associated with Rpp1 will permit marker‐assisted selection and expedite the incorporation of this gene into U.S. cultivars. We compared simple sequence repeat (SSR) markers between ‘Williams 82’ and the BC5 Williams 82 isoline L85‐2378, which contains the Rpp1 resistance allele from the soybean accession PI 200492, for candidate regions that might contain Rpp1 One candidate region was found with the SSR marker BARC_Sct_187 on linkage group G. A population of BC6F2:3 lines segregating for the Rpp1 resistance locus was genotyped in this region on linkage group G followed by inoculation with the P. pachyrhizi isolate India 73‐1 in the USDA‐ARS Biosafety Level 3 Plant Pathogen Containment Facility at Ft. Detrick, MD. The Rpp1 gene was mapped between SSR markers BARC_Sct_187 and BARC_Sat_064 on linkage group G.
Estimating the Proportion of Nitrogen Remobilization and of Postsilking Nitrogen Uptake Allocated to Maize Kernels by Nitrogen‐15 Labeling
Authors: Gallais A. , Coque M. , Le Gouis J. , Prioul J. L. , Hirel B. , Quilléré I. 
Published: July 2010

ABSTRACTEstimating the proportion of N remobilization and postsilking N uptake allocated to kernels may help to improve N‐use efficiency in maize (Zea mays L.). In this study, we show theoretically and experimentally, that 15N labeling at the beginning of stem elongation can be used in the field to estimate the proportion of N remobilized from the vegetative parts to the kernels of maize by measuring 15N distribution only at maturity. In the same way, 15N labeling at silking allows a determination of the proportion of postsilking N uptake allocated to the kernels by measuring 15N distribution only at maturity. Two 1‐yr experiments with three and four genotypes and one 2‐yr experiment with testcross progenies from 66 recombinant inbred lines were developed. Nitrogen‐15 labeling during vegetative growth provided an estimate of the proportion of N remobilized with a greater accuracy compared with the “balance” method, which computes the difference between the amount of N present in the stover at silking and the amount of N present in the stover at maturity. The validity of our 15N method is mainly based on the assumption that less than 15 to 20% of 15N is taken up after silking. The determination of the proportion of postsilking N uptake allocated to kernels requires assumptions that are more difficult to fulfill. Nitrogen‐15 labeling in the field at the beginning of rapid stem growth appears to be a useful tool for studying the genetic variability of N remobilization using a large number of genotypes.
Association Between Urinary Type IV Collagen Level and Deterioration of Renal Function in Type 2 Diabetic Patients Without Overt Proteinuria
Authors: Araki Shin-ichi , Haneda Masakazu , Koya Daisuke , Isshiki Keiji , Kume Shinji , Sugimoto Toshiro , Kawai Hiromichi , Nishio Yoshihiko , Kashiwagi Atsunori , Uzu Takashi , Maegawa Hiroshi 
Published: July 2010

OBJECTIVE
Cross-sectional studies have reported increased levels of urinary type IV collagen in diabetic patients with progression of diabetic nephropathy. The aim of this study was to determine the role of urinary type IV collagen in predicting development and progression of early diabetic nephropathy and deterioration of renal function in a longitudinal study.

RESEARCH DESIGN AND METHODS
Japanese patients with type 2 diabetes (n = 254, 185 with normoalbuminuria and 69 with microalbuminuria) were enrolled in an observational follow-up study. The associations of urinary type IV collagen with progression of nephropathy and annual decline in estimated glomerular filtration rate (eGFR) were evaluated.

RESULTS
At baseline, urinary type IV collagen levels were higher in patients with microalbuminuria than in those with normoalbuminuria and correlated with urinary β2-microglobulin (β = 0.57, P &lt; 0.001), diastolic blood pressure (β = 0.15, P &lt; 0.01), eGFR (β = 0.15, P &lt; 0.01), and urinary albumin excretion rate (β = 0.13, P = 0.01) as determined by multivariate regression analysis. In the follow-up study (median duration 8 years), urinary type IV collagen level at baseline was not associated with progression to a higher stage of diabetic nephropathy. However, the level of urinary type IV collagen inversely correlated with the annual decline in eGFR (γ = −0.34, P &lt; 0.001). Multivariate regression analysis identified urinary type IV collagen, eGFR at baseline, and hypertension as factors associated with the annual decline in eGFR.

CONCLUSIONS
Our results indicate that high urinary excretion of type IV collagen is associated with deterioration of renal function in type 2 diabetic patients without overt proteinuria.
Factors associated with hunter success for ducks on state‐owned lands in Illinois, USA
Authors: Stafford Joshua D. , Pearse Aaron T. , Hine Christopher S. , Yetter Aaron P. , Horath Michelle M. 
Published: July 2010

AbstractFactors that influence hunter success for waterfowl are subject to varying levels of control by managers. The relative influence of these factors is poorly understood, but such information may be valuable to guide management actions intended to promote successful hunting and communicate management decisions to constituents. We used bag‐check data to investigate factors influencing hunter success for mallards Anas platyrhynchos and other dabbling ducks (tribe Anatini) during the period 1981‐2000 and 2002 at Illinois public waterfowl areas. Competing models of hunter success for mallards and other dabbling ducks included a negative association with average low temperature during the duck season (uncontrollable by managers) and positive associations with estimates of local and continental duck abundance, factors which we considered partially controllable by managers. Although a certain proportion of variation in hunter success for ducks cannot be directly influenced by managers, we suggest that programs and management efforts, which promote larger continental duck populations (e.g. Conservation Reserve Program) and local duck abundance (e.g. provide quality wetland foraging habitats), may positively influence hunter success.
Requirement for Inducible Nitric Oxide Synthase in Chronic Allergen Exposure-Induced Pulmonary Fibrosis but Not Inflammation
Authors: Naura Amarjit S. , Zerfaoui Mourad , Kim Hogyoung , Abd Elmageed Zakaria Y. , Rodriguez Paulo C. , Hans Chetan P. , Ju Jihang , Errami Youssef , Park Jiwon , Ochoa Augusto C. , Boulares A. Hamid 
Published: July 2010

Abstract
The role of inducible NO synthase (iNOS) in allergic airway inflammation remains elusive. We tested the hypothesis that iNOS plays different roles during acute versus chronic airway inflammation. Acute and chronic mouse models of OVA-induced airway inflammation were used to conduct the study. We showed that iNOS deletion was associated with a reduction in eosinophilia, mucus hypersecretion, and IL-5 and IL-13 production upon the acute protocol. Such protection was completely abolished upon the chronic protocol. Interestingly, pulmonary fibrosis observed in wild-type mice under the chronic protocol was completely absent in iNOS−/− mice despite persistent IL-5 and IL-13 production, suggesting that these cytokines were insufficient for pulmonary fibrosis. Such protection was associated with reduced collagen synthesis and indirect but severe TGF-β modulation as confirmed using primary lung smooth muscle cells. Although activation of matrix metalloproteinase-2/-9 exhibited little change, the large tissue inhibitor of metalloproteinase-2 (TIMP-2) increase detected in wild-type mice was absent in the iNOS−/− counterparts. The regulatory effect of iNOS on TIMP-2 may be mediated by peroxynitrite, as the latter reversed TIMP-2 expression in iNOS−/− lung smooth muscle cells and fibroblasts, suggesting that the iNOS–TIMP-2 link may explain the protective effect of iNOS-knockout against pulmonary fibrosis. Analysis of lung sections from chronically OVA-exposed iNOS−/− mice revealed evidence of residual but significant protein nitration, prevalent oxidative DNA damage, and poly(ADP-ribose) polymerase-1 activation. Such tissue damage, inflammatory cell recruitment, and mucus hypersecretion may be associated with substantial arginase expression and activity. The results in this study exemplify the complexity of the role of iNOS in asthma and the preservation of its potential as a therapeutic a target.
Long-Term Human CD34+ Stem Cell-Engrafted Nonobese Diabetic/SCID/IL-2Rγnull Mice Show Impaired CD8+ T Cell Maintenance and a Functional Arrest of Immature NK Cells
Authors: André Maya C. , Erbacher Annika , Gille Christian , Schmauke Vanessa , Goecke Barbara , Hohberger Alexander , Mang Philippa , Wilhelm Ayline , Mueller Ingo , Herr Wolfgang , Lang Peter , Handgretinger Rupert , Hartwig Udo F. 
Published: July 2010

Abstract
Allogeneic hematopoietic stem cell transplantation represents the most effective form of immunotherapy for chemorefractory diseases. However, animal models have been missing that allow evaluation of donor-patient–specific graft-versus-leukemia effects. Thus, we sought to establish a patient-tailored humanized mouse model that would result in long-term engraftment of various lymphocytic lineages and would serve as a donor-specific surrogate. Following transfer of donor-derived peripheral blood stem cells into NOD/SCID/IL-2Rγnull (NSG) mice with supplementation of human IL-7, we could demonstrate robust engraftment and multilineage differentiation comparable to earlier studies using cord blood stem cells. Phenotypical and functional analyses of lymphoid lineages revealed that &gt;20 wk posthematopoietic stem cell transplantation, the majority of T lymphocytes consisted of memory-type CD4+ T cells capable of inducing specific immune functions, whereas CD8+ T cells were only present in low numbers. Analysis of NSG-derived NK cells revealed the expression of constitutively activated CD56brightCD16− killer Ig-like receptornegative NK cells that exhibited functional impairments. Thus, the data presented in this study demonstrate that humanized NSG mice can be successfully used to develop a xenotransplantation model that might allow patient-tailored treatment strategies in the future, but also highlight the need to improve this model, for example, by coadministration of differentiation-promoting cytokines and induction of human MHC molecules to complement existing deficiencies in NK and CD8+ T cell development.
Essential Role of Endogenous Heat Shock Protein 90 of Dendritic Cells in Antigen Cross-Presentation
Authors: Ichiyanagi Tomoko , Imai Takashi , Kajiwara Chiaki , Mizukami Shusaku , Nakai Akira , Nakayama Toshinori , Udono Heiichiro 
Published: July 2010

Abstract
Extracellular HSP90 associated with Ag peptides have been demonstrated to efficiently cross-prime T cells, following internalization by dendritic cells (DCs). In addition, the nature of cell-associated Ags required for cross-priming is implicated as peptides and proteins chaperoned by heat shock protein (HSP). However, the role of endogenous HSP in DCs during cross-presentation remains elusive. In this paper, we show that endogenous HSP90 is essential for cross-presentation of both soluble and cell-associated Ags in DCs. Cross-presentation of soluble OVA and OVA-loaded transporter associated with Ag processing-1–deficient cells by bone marrow-derived DCs and DC-like cell line DC2.4 was profoundly blocked by HSP90 inhibitors, whereas presentation of endogenously expressed OVA was only partially suppressed. Assays using small interfering RNA and heat shock factor-1–deficient DCs (with defective expression of HSP90α) revealed the pivotal role of HSP90α in cross-presentation. The results suggest that in addition to HSP90 in Ag donor cells, endogenous HSP90 in DCs plays an essential role during Ag cross-presentation and, moreover, points to a link between heat shock factor-1–dependent induction of HSP90α within DC and cytotoxic T cell immunity.
GILT Accelerates Autoimmunity to the Melanoma Antigen Tyrosinase-Related Protein 1
Authors: Rausch Matthew P. , Irvine Kari R. , Antony Paul A. , Restifo Nicholas P. , Cresswell Peter , Hastings K. Taraszka 
Published: July 2010

AbstractMelanocyte differentiation Ags, including tyrosinase-related protein (TRP) 1, are relevant to both autoimmune skin depigmentation (vitiligo) and tumor immunity, because they are expressed by both benign melanocytes and many malignant melanomas. Melanoma patients generate CD4+ T cells that specifically recognize these proteins. TRP1 contains internal disulfide bonds and is presented by MHC class II molecules. γ-IFN–inducible lysosomal thiol reductase (GILT) facilitates the generation of class II-binding peptides by the endocytic reduction of protein disulfide bonds. We show in this study that GILT is required for efficient MHC class II-restricted processing of a TRP1 epitope in vitro and accelerates the onset of vitiligo in TRP1-specific TCR transgenic mice. The presence of GILT confers a small increase in the percentage of autoreactive T cells with an effector memory phenotype that may contribute to earlier disease onset. The onset of vitiligo is associated with a greater increase in the percentage of autoreactive T cells with an effector memory phenotype. Given that many self and tumor Ags have disulfide bonds and are presented on MHC class II, GILT is likely to be important in the pathogenesis of other CD4+ T cell-mediated autoimmune diseases and for the development of effective cancer immunotherapy.
Multi-channel eBook production as a function of diverse target device capabilities
Authors: Freese Eric 
Published: July 2010

Publishers have a history of managing data for the long-term. In the past this meant warehouses of proof sheets. As the publishing process became electronic, assets were archived on tape or disk in the event of a need to re-release (perhaps due to a popular subsequent movie or other event). However, the challenge shifted from storage of materials to file compatibility and management of software versions. Then along came XML, which offered a vendor-agnostic format in which to, at a minimum, archive data if not becoming the format in which the data was authored. Now that publishers find themselves in the midst of an eBook boom they find themselves, yet again, dealing with managing different formats and, to complicate matters, dealing with different implementations of the same standard. This paper will discuss the current state of the trade, textbook, and journal publishing industry as it pertains to creating eBooks for current and backlist resources. It will also discuss the challenges faced by publishers as the technology continues to move forward toward “enhanced eBooks” at a pace faster than the standards can be updated.
A sample project will be presented which presents the challenges of producing eBooks in the current environment as well as demonstrates how current standards might support the next generation of eBooks.
IgM multiple myeloma: Disease definition, prognosis, and differentiation from Waldenstrom's macroglobulinemia
Authors: Schuster Steven R. , Rajkumar Sundararajan Vincent , Dispenzieri Angela , Morice William , Aspitia Alvaro Moreno , Ansell Stephen , Kyle Robert , Mikhael Joseph 
Published: July 2010

AbstractIgM multiple myeloma (MM) and Waldenstrom's macroglobulinemia (WM) are two distinct hematologic entities with the common finding of an IgM monoclonal gammopathy. Distinguishing these two diagnoses is critical as the approach to therapy is different. A priori, we defined IgM MM as a symptomatic clonal plasma cell proliferative disorder characterized by an IgM monoclonal protein (regardless of size), 10% or more plasma cells on bone marrow biopsy, plus the presence of lytic bone lesions and/or translocation t(11;14). Twenty‐one patients met this definition of IgM MM. All 21 patients had lytic bone lesions. Of the 16 evaluated with FISH, 6 (38%) demonstrated t(11;14). Median overall survival was 30 months, which is similar to non‐IgM myeloma patients treated during this period and shorter than what would be expected for WM. In this, the largest series of patients with IgM MM, we describe the clinical features and prognosis of patient with IgM MM using a strict definition for the disease. The subset of patients without lytic lesions or t(11;14) but with immunophenotypic features suggestive of MM need further study. Am. J. Hematol., 2010. © 2010 Wiley‐Liss, Inc.
Superiority of nanosized over microsized hyperbranched polymer second phase in modifying brittle epoxy resin
Authors: Yang Jiao‐Ping , Feng Qing‐Ping , Chen Zhen‐Kun , Fu Shao‐Yun 
Published: July 2010

AbstractA hydroxyl‐functionalized hyperbranched polymer (HBP, H30) is used to modify 4,4′‐diaminodiphenylsulfone‐cured bisphenol‐A type epoxy resin and a separate phase structure of modified epoxy resins is observed. The effects of the H30 second phase size on the mechanical properties of modified epoxy systems are investigated systematically. The dependence of the toughening mechanisms on the HBP particle size is reported for the first time. It is shown that the nanosized H30 second phase is superior over microsized counterparts in modifying brittle epoxy resin. The tensile strength is slightly enhanced by the introduction of nanosized H30 second phase, whereas the strength is significantly reduced by the addition of microsized H30 phase. The failure strain and impact strength are obviously enhanced by the introduction of nanosized H30 second phase at low contents, whereas these properties are reduced by the addition of microsized H30 second phase at high contents. Finally, differential scanning calorimetric and thermogravimetric analyses are conducted to examine the effects of the HBP content on the glass transition temperature and the thermal stability, respectively. The glass transition temperature is slightly reduced while the thermal stability is not obviously influenced by the introduction of H30 second phase. © 2010 Wiley Periodicals, Inc. J Appl Polym Sci, 2011
Epoxy curing reaction studied by using two‐dimensional correlation infrared and near‐infrared spectroscopy
Authors: Yamasaki Hideki , Morita Shigeaki 
Published: July 2010

AbstractThe isothermal curing process of bisphenol A epoxy resin with polyamine reagent (1,6‐diaminohexane) was monitored in situ by using temperature‐controlled Fourier‐transform infrared (FTIR) and Fourier‐transform near infrared (FTNIR) spectroscopy to elucidate the relative changes in functional groups during the curing reaction. It was shown that generalized two‐dimensional correlation spectroscopy can provide new information about the mechanisms and kinetics of the curing process, and the band assignments for complex NIR spectrum associated with this system. The sequential order of relative changes in functional groups during the curing process was examined by generalized 2D correlation spectroscopy and NIR‐IR hetero‐correlation spectroscopy, and the details of the complex epoxy curing reaction involving both primary and secondary amino group were revealed. © 2010 Wiley Periodicals, Inc. J Appl Polym Sci, 2011
CCL17/thymus and activation–related chemokine in Churg‐Strauss syndrome
Authors: Dallos Tomáš , Heiland Gisela Ruiz , Strehl Johanna , Karonitsch Thomas , Gross Wolfgang L. , Moosig Frank , Holl‐Ulrich Constanze , Distler Jörg H. W. , Manger Bernhard , Schett Georg , Zwerina Jochen 
Published: July 2010

AbstractObjectiveChurg‐Strauss syndrome (CSS) is a Th2‐mediated systemic vasculitis characterized by eosinophilic infiltration, blood eosinophilia, and high IgE levels. CCL17/thymus and activation–regulated chemokine (TARC) is a chemokine responsible for the recruitment of Th2 cells. This study was undertaken to explore a possible role of CCL17/TARC in CSS.MethodsCCL17/TARC levels in serum from patients with active or inactive CSS, hypereosinophilic syndrome, systemic small‐vessel vasculitis other than CSS, other types of eosinophilia, and healthy controls were determined by enzyme‐linked immunosorbent assay. Biopsy samples of affected tissue from CSS patients were examined by immunohistochemical staining for Th2 infiltration and CCL17/TARC expression.ResultsSerum CCL17/TARC levels were significantly elevated in CSS patients with active disease (mean ± SEM 1,122.0 ± 422.7 pg/ml) compared with controls (220.6 ± 27.9 pg/ml) and patients with inactive disease (388.9 ± 72.6 pg/ml) (P < 0.001 and P < 0.05, respectively). These levels correlated with the clinical disease course of CSS and with absolute eosinophil counts as well as IgE levels. Infiltrating Th2 cells in active CSS lesions were evidenced by CD294 staining. CCL17/TARC in the affected tissue of CSS patients was readily identified by immunohistochemical analysis. Elevated CCL17/TARC levels were also noted in patients with hypereosinophilic syndrome (794.5 ± 294.8 pg/ml) and other disorders associated with eosinophilia (1,096.0 ± 345.3 pg/ml) (both P < 0.005 versus controls).ConclusionCCL17/TARC may contribute to CSS pathogenesis by recruitment of Th2 cells into affected tissue. Serum CCL17/TARC levels reflect disease activity, and further studies to validate its use as an activity marker in CSS are warranted.
ChemInform Abstract: Cesium Hydroperoxostannate: First Complete Structural Characterization of a Homoleptic Hydroperoxocomplex.
Authors: Churakov Andrei V. , Sladkevich Sergey , Lev Ovadia , Tripol'skaya Tatiana A. , Prikhodchenko Petr V. 
Published: July 2010

AbstractThe title compound is obtained in 88% yield from a solution of Cs2Sn(OH)6 in 70 wt% H2O2.