bluuebunny/crossref_metadata_2025_split huggingface dataset:
Gadofosveset trisodium in the investigation of focal liver lesions in noncirrhotic liver: Early experience
Authors: Milot Laurent , Haider Masoom , Foster Lynette , McGregor Cailtin , Law Calvin 
Published: April 2012

AbstractPurpose:To investigate enhancement of hepatic lesions with gadofosveset trisodium (Gdfos) (Ablavar) (blood pool agent) compared with the extracellular gadolinium contrast agent (EcGd) gadobutrol (Gadovist).Materials and Methods:The prospective study was approved by the Institutional Research Ethics Board with informed consent. Twelve patients underwent magnetic resonance imaging (MRI) with EcGd followed by MRI with Gdfos. For each agent qualitative analysis described the pattern of enhancement and quantitative analysis was performed using lesion‐to‐liver contrast‐to‐noise (CNR) ratio. Paired and unpaired Student's t‐test used.Results:Twelve hemangiomas, four metastases, one cyst, two focal nodular hyperplasia (FNH), and three adenomas were found. Cyst, FNH, adenomas, and hemangiomas demonstrated the classic pattern of enhancement with both agents. Hemangiomas demonstrated retention of contrast with both agents and their CNR was not statistically different (P > 0.05). Metastases demonstrated retention of contrast on delayed phase with EcGd. Retention of contrast was not seen in metastases with Gdfos. CNR of metastases with Gdfos was statistically lower than CNR of metastases with EcGd (P = 0.005). CNR of hemangiomata and metastases on delayed phase were significantly different (P = 0.0008) with Gdfos, but similar with EcGd (P = 0.4).Conclusion:Hemangiomas accumulate Gdfos on delayed phase and metastases do not, a key additional differentiating feature. Liver imaging with Gdfos may improve characterization of liver lesions. J. Magn. Reson. Imaging 2012;36:738–742. © 2012 Wiley Periodicals, Inc.
Estimating size and trend of the North Interlake woodland caribou population using fecal‐DNA and capture–recapture models
Authors: Hettinga Peter N. , Arnason Arni Neil , Manseau Micheline , Cross Dale , Whaley Kent , Wilson Paul J. 
Published: April 2012

AbstractA critical step in recovery efforts for endangered and threatened species is the monitoring of population demographic parameters. As part of these efforts, we evaluated the use of fecal‐DNA based capture–recapture methods to estimate population sizes and population rate of change for the North Interlake woodland caribou herd (Rangifer tarandus caribou), Manitoba, Canada. This herd is part of the boreal population of woodland caribou, listed as threatened under the federal Species at Risk Act (2003) and the provincial Manitoba Endangered Species Act (2006). Between 2004 and 2009 (9 surveys), we collected 1,080 fecal samples and identified 180 unique genotypes (102 females and 78 males). We used a robust design survey plan with 2 surveys in most years and analysed the data with Program MARK to estimate encounter rates (p), apparent survival rates (φ), rates of population change (λ), and population sizes (N). We estimated these demographic parameters for males and females and for 2 genetic clusters within the North Interlake. The population size estimates were larger for the Lower than the Upper North Interlake area and the proportion of males was lower in the Lower (33%) than the Upper North Interlake (49%). Population rate of change for the entire North Interlake area (2005–2009) using the robust design Pradel model was significantly <1.0 (λ = 0.90, 95% CI: 0.82–0.99) and varied between sex and area with the highest being for males in Lower North Interlake (λ = 0.98, 95% CI: 0.83–1.13) and the lowest being for females in Upper North Interlake (λ = 0.83, 95% CI: 0.69–0.97). The additivity of λ between sex and area is supported on the log scale and translates into males having a λ that is 0.09 greater than females and independent of sex, Lower North Interlake having a λ that is 0.06 greater than Upper North Interlake. Population estimates paralleled these declining trends, which correspond to trends observed in other fragmented populations of woodland caribou along the southern part of their range. The results of this study clearly demonstrate the applicability and success of non‐invasive genetic sampling in monitoring populations of woodland caribou. © 2012 The Wildlife Society.
Antihelical shaping of prominent ears using conchal cartilage‐grafting adhesion
Authors: Park Chul , Jeong Tae‐Won 
Published: April 2012

AbstractObjectives/Hypothesis:No specific otoplasty method has been considered as the absolute standard in patients with prominent ears showing thick and strong auricular cartilage.Study Design:Retrospective case series study.Methods:The authors reviewed the chart and preoperative and postoperative photos of patients (N = 66) who underwent otoplasty consecutively with a new antihelical shaping technique using conchal cartilage‐grafting adhesion between 2003 and 2010. Three mattress sutures between the posterior scapha and concha wall were performed to create an antihelical tubing. A piece of conchal cartilage with an intact perichondrium was inserted through the posterior tubing gap and fixed to the posterior scapha and conchal wall, which induced permanent cartilage adhesion.Results:Thirty‐nine patients were female and 27 were male. The average age was 23.7 years. Prominent ears were bilateral in 24 patients and unilateral in 42 patients. All patients were observed for a postoperative duration of between 4 months and 24 months. Operative wounds in all patients healed uneventfully. Asymmetric ear projections due to undercorrection were observed in two patients, and mild irregularities or prominences on the postauricular surfaces were observed in three patients. Twenty‐two patients (27 corrected ears) were interviewed by telephone to evaluate their long‐term satisfaction (an average of 5.2 years after surgery). All except one reported their corrected ears as good.Conclusions:The conchal cartilage‐grafting adhesion technique creates a naturally shaped smooth antihelix, allowing the prominent ear to predictably and permanently set back. We believe that the method is indicated in adult patients showing thick and strong auricular cartilage. Laryngoscope, 2012
Patient‐reported speech in noise difficulties and hyperacusis symptoms and correlation with test results
Authors: Spyridakou Chrysa , Luxon Linda M. , Bamiou Doris E. 
Published: April 2012

AbstractObjectives/Hypothesis:To compare self‐reported symptoms of difficulty hearing speech in noise and hyperacusis in adults with auditory processing disorders (APDs) and normal controls; and to compare self‐reported symptoms to objective test results (speech in babble test, transient evoked otoacoustic emission [TEOAE] suppression test using contralateral noise).Study Design:A prospective case–control pilot study.Methods:Twenty‐two participants were recruited in the study: 10 patients with reported hearing difficulty, normal audiometry, and a clinical diagnosis of APD; and 12 normal age‐matched controls with no reported hearing difficulty. All participants completed the validated Amsterdam Inventory for Auditory Disability questionnaire, a hyperacusis questionnaire, a speech in babble test, and a TEOAE suppression test using contralateral noise.Results:Patients had significantly worse scores than controls in all domains of the Amsterdam Inventory questionnaire (with the exception of sound detection) and the hyperacusis questionnaire (P < .005). Patients also had worse TEOAE suppression test results in both ears than controls; however, this result was not significant after Bonferroni correction. Strong correlations were observed between self‐reported symptoms of difficulty hearing speech in noise and speech in babble test results in the right ear (ρ = 0.624, P = .002), and between self‐reported symptoms of hyperacusis and TEOAE suppression test results in the right ear (ρ = −0.597 P = .003).Conclusions:There was no significant correlation between the two tests. A strong correlation was observed between right ear speech in babble and patient‐reported intelligibility of speech in noise, and right ear TEOAE suppression by contralateral noise and hyperacusis questionnaire. Laryngoscope, 2012
Stimuli‐Responsive Peptide‐Based ABA‐Triblock Copolymers: Unique Morphology Transitions With pH
Authors: Ray Jacob G. , Naik Sandeep S. , Hoff Emily A. , Johnson Ashley J , Ly Jack T. , Easterling Charles P. , Patton Derek L. , Savin Daniel A. 
Published: April 2012

AbstractWe report the synthesis and solution characterization of poly(L‐lysine)‐b‐poly(propylene oxide)‐b‐poly(L‐lysine) (KPK) triblock copolymers with high lysine weight fractions (>75 wt%). In contrast to PK diblock copolymers in this composition range, KPK triblock copolymers exhibit morphology transitions as a function of pH. Using a combination of light‐scattering and microscopy techniques, we demonstrate spherical micelle‐vesicle and spherical micelle‐disk micelle transitions for different K fractions. We interpret these morphology changes in terms of the energy penalty associated with folding the core P block to form a spherical micelle in relation to the interfacial curvature associated with different charged states of the K block.
Chemotherapy compliance in patients with osteosarcoma
Authors: Bajpai Jyoti , Puri Ajay , Shah Kajal , Susan Deepa , Jambhekar Nirmala , Rekhi Bharat , Desai Saral , Gulia Ashish , Gupta Sudeep 
Published: April 2012

AbstractPurposeHistological response (HR) to neoadjuvant‐chemotherapy (NACT) is considered as a robust prognostic marker in treated osteosarcomas. Chemotherapy compliance can affect both, dose intensity and density and may affect the final outcome in these cases. This vital aspect has been inadequately addressed and therefore merits further investigation.MethodA retrospective study of NACT‐treated osteosarcoma patients, during the year 2010 was conducted. Compliance was defined as receipt of planned cycles of chemotherapy in the planned doses, within the planned duration or up to 25% additional time. HR was assessed by grading for histological necrosis (HN). Good responders (GR) included those with tumors showing ≥90% HN.ResultsOf 124 patients, 115 were analyzed for post‐NACT HR. Of the 73 (64%) compliant patients, 47 were GR and of the 42 (36%) non‐compliant patients, 18 were GR. There was significant association between GR and compliance (P = 0.031). However, at a median follow‐up of 7.9 months, there was no significant difference in survival between the noncompliant versus compliant group. Non‐compliance was justifiable in 26 patients and not justifiable in 16 patients. Using univariate analysis, T‐size, pain, performance status, albumin, LDH, and education were identified as significant factors, while in multivariate analysis, only poor performance status was identified as an independent variable for non‐compliance.ConclusionsTwo‐thirds patients were found to be compliant with NACT. There was a significant association between GR and compliant patients. Significant correlation between compliance and survival may be established with a longer follow‐up particularly since “good necrosis” is generally predictive of good survival. Pediatr Blood Cancer 2013; 60: 41–44. © 2012 Wiley Periodicals, Inc.
A time‐dependent Lagrangian eyewall
Authors: Rutherford Blake , Dangelmayr Gerhard , Kirby Michael 
Published: April 2012

AbstractThe structure of a tropical cyclone eye and eyewall plays an important role in intensification. While the eyewall is usually defined in terms of instantaneous velocity and derived quantities such as vorticity, or thermodynamic variables such as equivalent potential temperature, or pressure, a Lagrangian eyewall definition is based on the transport of particles. In this paper, we analyse a Lagrangian eye–eyewall interface (LEEI), which is defined as a surface that acts as barrier to particle motion. The surface is identified with a maximal ridge of a hyperbolic Lagrangian field, and varies with the initial time at which particles are seeded. Our study extends a previous LEEI construction (Rutherford B, Dangelmayr G. 2010. Q. J. R. Meteorol. Soc. 136: 1931–1944) as follows. First, the ridge extraction algorithm used in our previous work is fully automated over time and z‐levels, and smoothed by representing the ridge curves on z‐slices in terms of Fourier descriptors. Secondly, the ridge curves for varying z‐levels are matched to vertical basis functions leading to a 3D spatially continuous and low‐dimensional representation of the LEEI, by truncating the combined azimuthal and vertical expansion. The surface is then analysed over varying initial time, and structural differences in time and height show that differences in Lagrangian structure and the degree of axisymmetry correspond to changes in intensity. Copyright © 2012 Royal Meteorological Society
Study of LPIN1, LPIN2 and LPIN3 in rhabdomyolysis and exercise‐induced myalgia
Authors: Michot Caroline , Hubert Laurence , Romero Norma B. , Gouda Amr , Mamoune Asmaa , Mathew Suja , Kirk Edwin , Viollet Louis , Rahman Shamima , Bekri Soumeya , Peters Heidi , McGill James , Glamuzina Emma , Farrar Michelle , der von Hagen Maya , Alexander Ian E. , Kirmse Brian , Barth Magalie , Laforet Pascal , Benlian Pascale , Munnich Arnold , JeanPierre Marc , Elpeleg Orly , Pines Ophry , Delahodde Agnès , de Keyzer Yves , de Lonlay Pascale 
Published: April 2012

AbstractBackgroundRecessive LPIN1 mutations were identified as a cause of severe rhabdomyolysis in pediatric patients. The human lipin family includes two other closely related members, lipin‐2 and 3, which share strong homology and similar activity. The study aimed to determine the involvement of the LPIN family genes in a cohort of pediatric and adult patients (n = 171) presenting with muscular symptoms, ranging from severe (CK >10 000 UI/L) or moderate (CK <10 000 UI/L) rhabdomyolysis (n = 141) to exercise‐induced myalgia (n = 30), and to report the clinical findings in patients harboring mutations.MethodsCoding regions of LPIN1, LPIN2 and LPIN3 genes were sequenced using genomic or complementary DNAs.ResultsEighteen patients harbored two LPIN1 mutations, including a frequent intragenic deletion. All presented with severe episodes of rhabdomyolysis, starting before age 6 years except two (8 and 42 years). Few patients also suffered from permanent muscle symptoms, including the eldest ones (≥40 years). Around 3/4 of muscle biopsies showed accumulation of lipid droplets. At least 40% of heterozygous relatives presented muscular myalgia. Nine heterozygous SNPs in LPIN family genes were identified in milder phenotypes (mild rhabdomyolysis or myalgia). These variants were non‐functional in yeast complementation assay based on respiratory activity, except the LPIN3‐P24L variant.ConclusionLPIN1‐related myolysis constitutes a major cause of early‐onset rhabdomyolysis and occasionally in adults. Heterozygous LPIN1 mutations may cause mild muscular symptoms. No major defects of LPIN2 or LPIN3 genes were associated with muscular manifestations.
Planning for Cross-Border Territories: The Role Played by Spatial Information
Authors: Peyrony Jean , Denert Olivier 
Published: April 2012

The authors argue that cross-border territories require not only an integrated approach to development, but also a form of cross-border governance that is democratic and pursues a multi-stage strategy in order to ensure accountability towards citizens and socio-economic actors and make certain that they are acknowledged and receive support at a regional and national level. At present, relevant statistical indices are lacking for most cross-border territories. Such indices are essential, however, for establishing a shared body of regional knowledge as a basis for developing joint policies and activities. Shared border areas presuppose that development takes place on both sides in order to overcome the negative effects of borders, to fully exploit the potential arising from the development of projects, and to address the needs of the inhabitants.
This article examines the part played by spatial information in the planning of cross-border areas. It examines the concept of “cross-border territory”, shows the diverse criteria applied in European regional planning as exemplified in the border region of France and Luxemburg, and considers which tools are available—from the standpoint of multi-level governance—for this purpose. Ultimately, it is a question of addressing the needs, challenges and potential offered by spatial information in a cross-border context.
Space D*
Authors: Silveira Luan , Maffei Renan Q. , Botelho Silvia S. C. , Drews Paulo L. , Bicho Alessandro de L. , Duarte Filho Nelson L. 
Published: April 2012

Abstract
This paper describes a new method of path-planning for multiple robots in unknown environments. The method, called Space D*, is based on two algorithms: the D*, which is an incremental graph search algorithm, and the Space Colonization algorithm, previously used to simulate crowd behaviors. The path-planning is achieved through the exchange of information between the robots. So decentralized, each robot performs its path-planning, which provides an obstacle-free path with the least number of robots around. The major contribution of the proposed method is that it generates paths in spacious environments facilitating the control of robots and thus presenting itself in a viable way for using in areas populated with multiple robots. The results obtained validate the approach and show the advantages in comparison with using only the D* method.
Identity, intimacy, status and sex dating goals as correlates of goal‐consistent behavior and satisfaction in Australian youth
Authors: Kelly Marguerite , Zimmer‐Gembeck Melanie J. , Boislard‐P Marie‐Aude 
Published: April 2012

ABSTRACTThe most common dating goals of adolescents are identity, intimacy, status and sex. In this study of Australian youth (16–30 years, N = 208), dating goals were expected to explain goal‐consistent behavior in each domain. Also, goals coupled with consistent behavior were expected to be associated with greater satisfaction in each domain. Age, gender, same‐sex versus other‐sex attraction, and cohabitation were also examined. The four dating goals had small intercorrelations, and for each domain but sex, youth who reported more of a dating goal also reported more goal‐consistent behavior. For identity, intimacy and sex, participants were more satisfied when they had more goal‐consistent behavior. Goal × Behavior interactions were associated with satisfaction in the domains of intimacy and sex, and identity was the most salient dating goal domain. Individual differences in goals, behavior and satisfaction were most pronounced for gender and cohabitation. Few differences were found between same‐sex and other‐sex attracted youth.
Rip Van Winkle's Odyssey
Authors: STALEY GREGORY A. 
Published: April 2012

The wise Ulysses was more indebted to his sleeping than his waking moments for his most subtle achievements, and seldom undertook any great exploit without first soundly sleeping upon it…James Joyce was the first reader of Washington Irving's famous tale of Rip Van Winkle to have noticed that Rip is ‘a lazy Odysseus’, as Andrew Burstein has more recently described him. Rip leaves home for twenty years, just as Odysseus did; however, unlike Odysseus, Rip spends this time not heroically fighting and adventuring but sleeping away his mature years. When he finally returns home, then, it is no surprise that the dog in front of his house ‘has forgotten' him, unlike Odysseus’ dog, who greets his master with a tail-wag of recognition. Irving creates in Rip Van Winkle an ironic and humorous embodiment of an Odysseus/Ulysses who, as quoted above, was ‘more indebted to his sleeping than his waking moments for his most subtle achievements’.
An executive's handbook for understanding and risk managing unit linked guarantees ‐ Abstract of the London discussion
Authors: Maher James 
Published: April 2012

This abstract relates to the following paper:MaherJ., CorriganJ., BentleyA., and DiffeyW.An executive's handbook for understanding and risk managing unit linked guarantees. British Actuarial Journal, doi:10.1017/S1357321712000013
Particle-size distributions and seasonal diversity of allergenic and pathogenic fungi in outdoor air
Authors: Yamamoto Naomichi , Bibby Kyle , Qian Jing , Hospodsky Denina , Rismani-Yazdi Hamid , Nazaroff William W , Peccia Jordan 
Published: April 2012

Abstract
Fungi are ubiquitous in outdoor air, and their concentration, aerodynamic diameters and taxonomic composition have potentially important implications for human health. Although exposure to fungal allergens is considered a strong risk factor for asthma prevalence and severity, limitations in tracking fungal diversity in air have thus far prevented a clear understanding of their human pathogenic properties. This study used a cascade impactor for sampling, and quantitative real-time PCR plus 454 pyrosequencing for analysis to investigate seasonal, size-resolved fungal communities in outdoor air in an urban setting in the northeastern United States. From the 20 libraries produced with an average of ∼800 internal transcribed spacer (ITS) sequences (total 15 326 reads), 12 864 and 11 280 sequences were determined to the genus and species levels, respectively, and 558 different genera and 1172 different species were identified, including allergens and infectious pathogens. These analyses revealed strong relationships between fungal aerodynamic diameters and features of taxonomic compositions. The relative abundance of airborne allergenic fungi ranged from 2.8% to 10.7% of total airborne fungal taxa, peaked in the fall, and increased with increasing aerodynamic diameter. Fungi that can cause invasive fungal infections peaked in the spring, comprised 0.1–1.6% of fungal taxa and typically increased in relative abundance with decreasing aerodynamic diameter. Atmospheric fungal ecology is a strong function of aerodynamic diameter, whereby through physical processes, the size influences the diversity of airborne fungi that deposit in human airways and the efficiencies with which specific groups of fungi partition from outdoor air to indoor environments.
Investigation of generation of defects due to metallization on CdZnTe detectors
Authors: Zheng Q , Dierre F , Franc J , Crocco J , Bensalah H , Corregidor V , Alves E , Ruiz E , Vela O , Perez J M , Dieguez E 
Published: April 2012

Abstract
The influence of deposition methods and type of metal contacts on the defects generated at the metal/semiconductor interface has been investigated. Photoluminesccence spectra at a low temperature demonstrated that the Au electroless deposition samples exhibit the lowest I
(D0,X)/I
A-center ratio and have the best gamma response. Rutherford backscattering spectrometry results show that the sputtering method creates the highest concentration of TeO2 layer compared with the evaporation and electroless deposition methods. The electroless Au has more inter-diffusion between the contact and the CZT material than either sputtering or evaporation methods. The electroless Pt and Ru depositions, however, exhibit lower inter-diffusion. The contacts deposited by electroless and evaporation present more quasi-ohmic behaviour and better gamma response than those fabricated by sputtering.