bluuebunny/crossref_metadata_2025_split huggingface dataset:
New synthesis of 1,2,3‐thiadiazole‐5‐thiol derivatives
Authors: Curran William V. , Sassiver Martin L. , Boothe James H. , Jacob Linda 
Published: April 2009

AbstractNew syntheses of 1,2,3‐thiadiazole‐5‐thiol derivatives utilizing the thionyl chloride ring‐closure of the aldehyde derivatives 5a, b, and c are reported.
Electronic structure of 4H‐pyrido[1,2‐a]pyrimidin‐4‐ones
Authors: Horváth Gábor , Hermecz István , Horváth Ágnes , Pongor‐Csákvári Marianna , Pusztay Levente , Kiss Árpád István , Czakó László , Abdirizak Osman Hassan 
Published: April 2009

AbstractThe characteristic features of ir and uv spectra of 43 4H‐pyrido[1,2‐a]pyrimidin‐4‐one derivatives with electron donor or acceptor groups in position 3, and positions 6, 7, 8, or 9, respectively, have been systematically studied. On the basis of the spectra some conclusions have been drawn for the molecular structure. The negative solvent effect of the lowest‐energy π → π* transition is investigated by the PPP method.
Facile synthesis of furans from 2‐ene‐1,4‐diones by diphosphorus tetraiodide
Authors: Demirdji S. H. , Haddadin M. J. , Issidorides C. H. 
Published: April 2009

AbstractDiphosphorus tetraiodide effects reductive ring‐closure of a variety of 2‐ene‐1,4‐diones into furans within a few minutes at room temperature.
Heterodiene synthesis. Synthesis of fused thiopyrano [2,3‐d]thiazole, Benzopyrano[3′,4′:4,5]thiopyrano[2,3‐d]thiazole and thiazolo[3,4‐c]triazine derivative
Authors: Allah Sanaa O. Abd , Hammouda Hamdy A. , Ali Fatma A. 
Published: April 2009

Abstract5‐Salicylidenethiazolidine‐2,4‐dithione (1) reacts with acrylonitrile,N‐phenylmaleimide and dimethyl acet‐ylenedicarboxylate to afford the fused thiopyrano[2,3‐d]thiazolidinethione derivatives2, 4and6, respectively. The salicylidene derivative1reacts with ethyl acrylate and malononitrile to afford the fused [1]benzopyrano[3′,4′:4,5]thiopyrano[2,3‐d]thiazoles3and9, respectively. 4‐Phenylhydrazono‐2‐thiazolidinethione (11) reacts with ethyl bromoacetate and/or phenacyl bromide to yield the fused thiazolo[3,4‐c]triazines13and14.
Synthetic approaches to unsaturated five‐membered heterocycles containing both ring and side‐chain phosphorus atoms
Authors: Amin Md. , Holah David G. , Hughes Alan N. , Rukachaisirikul Thitima 
Published: April 2009

AbstractThe syntheses of several structurally interesting 2‐diphenylphosphinyl‐substituted 2‐phospholenes and phospholanes are reported together with a discussion of the 31P and 13° C nmr spectral properties of these compounds. Several of these syntheses were found to be highly stereoselective and the potential of some of the products of these reactions as precursors to phosphole derivatives bearing phosphorus‐containing side‐chains has also been explored. A new, and possibly general, route to 4‐oxo‐2‐phospholene oxides or sulfides from the corresponding 4‐methylene compounds is also reported. This route involves an unusual free‐radical catalyzed oxidative cleavage of the 4‐methylene group by molecular oxygen and a probable mechanism for this reaction is proposed.
A convenient route for the synthesis of s,s‐and R,R‐warfarin alcohols
Authors: Jeyaraj G. L. , Porter W. R. 
Published: April 2009

AbstractS,S‐and R,R‐warfarin alcohols 3 are prepared in good yield and in 99% d.e. (diastereomeric excess) by the reaction of S‐ or R‐warfarin 1 with S or R‐Alpine‐Hidride 2.
2,4,4‐trisubstituted 5‐amino‐4h‐imidazoles. A new synthetic approach and reactivity
Authors: Avendaño C. , Ramos T. , Gómez‐Molinero E. 
Published: April 2009

AbstractThe scope and limitations of the reaction between imidates and α,α‐disubstituted α‐aminoacetonitriles to give 5‐amino‐4H‐imidazoles are studied. The reactivity of compounds 1a‐b has been explored.
1‐Methylphenanthro[3,4‐b]thiophene: Determination of the tertiary structure in solution and in the crystalline state by NMR spectroscopy and X‐ray diffraction
Authors: Musmar M. J. , Martin Gary E. , Gampe Robert T. , Lynch Vincent M. , Simonsen Stanley H. , Lee Milton L. , Tedjamulia Marvin L. , Castle Raymond N. 
Published: April 2009

Abstract1‐Methylphenanthro[3,4‐b]thiophene was prepared by the photocyclization of 1‐(4′‐methyl‐2′‐thienyl)‐2‐(2″‐naphthyl)ethene. The 1H and 13C‐nmr spectra were assigned using two‐dimensional 1H/13C heteronuclear chemical shift correlation and relayed coherence transfer (RELAY) experiments. From nuclear Overhauser difference spectra, the H11‐C1 methyl‐H intramolecular distance was determined to be 2.10 Å. The molecule crystallized from chloroform in the monoclinic system, space group P21/c. A total of 3536 unique reflections were measured and the structure was solved by direct methods and refined to a final R = 0.049. The molecule is helical with both chiral forms observed in the crystal. The H11‐C1 methyl‐H distance in the crystal was 2.12(3)Å in excellent agreement with the distance measured in solution by NOE techniques.
Imino‐bridged heterocycles. III . Synthesis of mono‐bridgehead substituted 11H‐benzo[5,6]cyclohepta[1,2‐c]pyridin‐6,11‐imines by regiospecific amine to olefin cyclizations
Authors: Brenner Daniel G. , Halczenko Wasyl , Shepard Kenneth L. 
Published: April 2009

AbstractEmploying regiospecific amine to endocyclic olefin and hydroxylamine to exocyclic olefin cyclizations, we have developed pathways to two isomeric, bridgehead methyl‐substituted benzo[5,6]cyclohepta[1,2‐c]pyridin‐6,11‐imines. Acid catalyzed cyclization of 5 to 6 was accomplished under exceedingly mild conditions (silica gel/chloroform), whereas, thermal cyclization of 20 to generate 21 was performed analogously to the dibenzo[a,d]cyclohepten‐5,10‐imine system.
Heterocyclic‐fused benzopyrans as cannabinoid analogues
Authors: Press Jeffery B. , Birnberg Gary H. 
Published: April 2009

AbstractA series of A‐ring heterocyclic analogues of tetrahydrocannabinol were investigated. Chromanones 1a and 1b were functionalized by formylation with base and ethyl formate to give 6a and 6b. These formylketones were reacted with hydrazine, and Phenylhydrazine to give pyrazoles 7a,b,e, and f, respectively. When 6a and 6b were reacted wtih methylhydrazine, mixtures of methyl isomers 7c and 8a and 7d and 8b formed in a ratio of 1:2.5. Isoxazoles 10a and 10b formed similarly when hydroxylamine was used as the condensing agent. Attempts to prepare the pyrimidine derivatives 11 were thwarted by the rearrangements of 6a and 6b to chromenones 12a and 12b.
4‐Hydroxy‐1(2H)‐isoquinolone‐3‐carboxamides synthesis and properties
Authors: Schapira Celia B. , Abasolo María I. , Perillo Isabel A. 
Published: April 2009

AbstractReaction of some α‐phthalimidoacetamides 1a‐i with sodium ethoxide was carried out under drastic conditions. Compounds 1b‐g afforded 4‐hydroxy‐1(2H)‐isoquinolone‐3‐carboxamides 2b‐g, while 1h‐i afforded the acid 3a‐b together with the expected isoquinolones 2h‐i. Compound 1a gave phthalimide as the major product. Compounds 2 are acidic and unstable in basic media. The most acidic compounds presented the longest half‐life. An explanation of these results was given.
Use of hypervalent iodine oxidation for the C(3)‐hydroxylation of chromone, flavone and α‐naphthoflavone
Authors: Moriarty Robert M. , Prakash Om , Musallam H. A. 
Published: April 2009

AbstractC(3)‐Hydroxylation of chromone (1a), flavone (1b) and α‐naphthoflavone (4) via acid‐catalysed hydrolysis of the corresponding β‐methoxy‐α‐hydroxydimethylacetals (2a, 2b, and 5) formed by iodobenzene diacetate‐potassium hydroxide methanol oxidation is described.
Chemische eigenschaften und synthese‐verfahren von 3‐vinylindolen
Authors: Akgün E. , Pindur U. 
Published: April 2009

AbstractSelectively functionalized 3‐vinylindoles are mostly stable compounds, which may serve as potent building blocks for anellation of the indole nucleus, in particular for synthesis of carbazole alkaloides and to obtain pharmacologically active compounds. This review describes from a great number of the permanent increasing literature of vinylheterocycles the chemical properties, the most important principles of the synthetic methods and the synthetic applications of 3‐vinylindoles. Among the synthetic methods to obtain 3‐vinylindoles the classical condensation, the Wittig‐Horner‐/Wadsworth‐Emmons‐Olefination and the recently developed Pd‐catalyzed vinylation should be considered as reliable standard methods. Depending on the special functionalization in the desired product some others methodologies are developed, so the thermolysis or the acid catalyzed ipso‐cleavage of hetarylindolylethanes for deriving 1‐hetaryl‐1‐indolylethenes.
Nitrogen bridgehead compounds. Part 50. Vilsmeier‐haack acylation of 6,7,8,9‐tetrahydro‐4H‐pyrido[1,2‐a]pyrimidin‐4‐ones, Part 5
Authors: Horváth Ágnes , Hermecz István , Podányi Benjamin , Mészáros Zoltán 
Published: April 2009

Abstract6‐Methyl‐6,7,8,9‐tetrahydro‐4H‐pyrido[1,2‐a]pyrimidin‐4‐ones 1‐5 were subjected to Vilsmeier‐Haack acylation with complexes of phosphoryl chloride and different amides. Acylation at position 9 of the pyridopyrim‐idines was successful with the iminium salt formed in situ from N‐formylpiperidine, N‐methylformanilide or N,N‐diethylbenzamide, but unsuccessful with the iminium salt formed from N,N‐diethylacetamide or N,N‐di‐ethylisobutyramide, respectively. The iminium salt formed from formanilide, N‐methylpyrrolidinone or formamide reacted only with those tetrahydropyridopyrimidinones which contain a strongly electronegative substituent (e.g. CN or CO2Et) in position 3. With the latter derivatives, the 9‐phenylaminomethylene group could be introduced using N,N‐diphenylformamide or in a “one‐pot” procedure with aniline and triethyl orthoformate. Ethanolysis of 9‐N‐methyl‐N‐phenylaminomethylene derivatives 15 and 19 afforded 9‐ethoxy‐methylene compounds 26 and 27 in the presence of hydrogen chloride. The structures of the 9‐substituted 6‐methyltetrahydropyridopyrimidin‐4‐ones 14‐25 were elucidated by means of uv, 1H and 13C nmr spectroscopy. 9‐Piperidinomethylene 14, 9‐(N‐methyl‐N‐phenylaminomethylene 15‐19 and 9‐(N‐methyl‐2‐pyrrolidinylidene) 21 derivatives exist as E geometric isomers. 9‐Phenylaminomethylene‐6‐methyl‐4‐oxo‐6,7,8,9‐tetra‐hydro‐4H‐pyrido[1,2‐a]pyrimidine‐3‐carbonitrile 20 displays a solvent‐dependent E‐Z isomerism. The bis‐compound 25 contains both E and Z geometric exo C  CH double bonds. 9‐Benzoyl derivatives 23 and 24 exist predominantly as the 1,6,7,8‐tetrahydropyridopyrimidin‐4‐one tautomer.
Synthesis of nitrogen heterocycles by condensation of the conjugate base of open‐chain reissert compound analogs with vinyltriphenylphosphonium bromide (schweizer's salt)
Authors: Cooney John V. , Beaver Bruce D. , Mcewen William E. 
Published: April 2009

AbstractReaction of the conjugate base of several open‐chain Reissert compound analogs with vinyltriphenylphosphonium bromide is shown to afford a convenient route to substituted pyrroles. The condensation is a two‐step process involving an initial reversible addition to form an unstabilized Wittig reagent followed by an intramolecular Wittig reaction upon the carbonyl group of the tertiary amide functionality with concomitant elimination of HCN. Several applications to the synthesis of 1,2,5‐trisubstituted pyrroles are presented, together with attempts to expand this methodology to the synthesis of other heterocyclic systems.
Conformation and bonding in unsymmetrically 3,6‐disubstituted dihydro‐1,2,4,5‐tetrazine
Authors: Pilgram Kurt H. , Gale Laird H. , Skiles Richard D. 
Published: April 2009

AbstractThe molecular structure of the title compound, I, has been determined by single‐crystal X‐ray diffraction. The crystals are triclinic, space group PI. The analysis revealed that the dihydro‐s‐tetrazine molecule is in a slightly twisted boat conformation with the nitrogen atoms carrying the two hydrogens, N(2) and N(4), pointing upward. All substituents on the dihydro‐s‐tetrazine ring exist in pseudo‐equatorial configurations. Adjacent hydrogen and bulky groups (CF3 and p‐Cl‐C6H4) have cis‐relationships. The p‐chlorophenyl group is twisted with respect to the dihydro‐s‐tetrazine ring. The unit cell for I contains six molecules. Each dihydro‐s‐tetrazine ring participates in four intermolecular hydrogen bonds (N···H bond distance 2.23 to 2.41 A), two hydrogen bonds to each adjacent tetrazine ring in the same unit cell.
13C‐NMR spectra and carbon‐proton coupling constants of variously annulated furocoumarins
Authors: Guiotto A. , Manzini P. , Chilin A. , Pastorini G. , Rodighiero P. 
Published: April 2009

AbstractThe 13C‐nmr spectra of variously annulated methylfurocoumarins are reported. The assignments of chemical shifts for all the C resonances has been achieved by using carbon‐proton coupling constants, relaxation efficiency considerations and shift effects caused by the introduction of methyl groups at various positions of the furocoumarin nucleus. Substituent effects on 13C chemical shifts and carbon‐proton coupling constants are discussed.
Synthesis of 2‐deamino‐ and 2‐deamino‐2‐nitroactinomycin D
Authors: Sehgal Raj K. , Sengupta Sisir K. , Dieter R. Karl 
Published: April 2009

AbstractA single step synthesis of 2‐deaminoactinomycin D (3a) and 2‐deamino‐2‐nitroactinomycin D (2a) arising from actinomycin D (1a, AMD) is reported. Structural confirmation was made by nmr, ir and chemical conversion to known materials.
Synthese von pyridylphenyl‐imidazo[2,1‐b]thiazolen
Authors: Klose Walter , Schwarz Katica 
Published: April 2009

AbstractThe synthesis of the isomeric 6(5)‐phenyl‐5(6)‐pyridyl‐2,3‐dihydroimidazo[2,1‐b]thiazoles are described. Only the synthesis of 5‐phenyl‐6‐(2‐pyridyl)‐2,3‐dihydroimidazo[2,1‐b]thiazole failed.
Crystal and molecular structure of 3,4,4,5‐tetramethyl‐1‐(p‐methoxybenzoyl)‐5‐(p‐methoxybenzoylazo)‐2‐pyrazoline
Authors: Stephanidou‐Stephanatou J. , Alexandrou N. E. , Salem G. , Terzis A. 
Published: April 2009

AbstractThe crystal and molecular structure of the title compound, derived by lead tetraacetate oxidation of the bis‐p‐methoxybenzoylhydrazone of 3,3‐dimethylpentane‐2,4‐dione, is studied by an X‐ray crystallographic analysis.
2‐Methylpyridinium salts as 1,4‐dinucleophiles. Quinolizinium salts from the westphal condensation
Authors: Alvarez‐Builla J. , Trigo G. Gonzalez , Ezquerra J. , Fombella M. E. 
Published: April 2009

AbstractCondensation of 2‐methylpyridinium salts with 1,2‐dicarbonyls in the presence of base, yielded 2,3‐disubstituted quinolizinium compounds. Results obtained with different pyridinium substrates are discussed.
The electron‐impact mass spectra of 1,2‐benzisoxazole N‐oxides
Authors: Tsiamis C. , Tsoungas P. G. 
Published: April 2009

AbstractThe mass spectra of a new class of heterocyclic N‐oxides are reported. It is proposed that the fragmentation processes proceed either by an initial deoxygenation, and or an impact‐induced isomerisation, prior to fragmentation. Substituents on the carbocyclic ring normally confer stability on the m olecular ions, whereas those on the heterocyclic ring open up additional fragmentation modes. A phenyl group at the 3‐position allows an intramolecular oxygen transfer prior to fragmentation.
Rearrangement of 3‐methoxy substituted [2, 1]benzisoxazole‐ and naphth[2,3‐c]isoxazolequinones in dimethyl sulfoxide solution
Authors: Torres Tomás , Eswaran S. V. , Schäfer Wolfram 
Published: April 2009

AbstractThe reactions of the 3‐methoxy‐isoxazole quinones 1 and 9 in a highly polar solution of dimethyl sulfoxide have been studied. Quinones of type 2, 4/11, 5/12, 6 and 7/13 have been isolated; nmr measurements give a detailed insight into the reaction mechanism.
Synthesis of 1,4‐dihydro‐4‐oxopyrrolo[3,4‐b]pyridine‐3‐carboxylic acid derivatives as potential antimicrobial agents
Authors: Bayomi Said M. , Price Kenneth E. , Sowell J. Walter 
Published: April 2009

AbstractA route for the synthesis of various derivatives of 1,4‐dihydro‐4‐oxopyrrolo[3,4‐b]pyridine‐3‐carboxylic acid from 2‐phenyl‐3‐amino‐4‐t‐butoxycarbonyl‐5‐methylpyrrole hydrochloride is reported.
One‐step synthesis of 3‐amino‐2,4‐imidazolinediones (3‐aminohydantoins) from α‐amino acids
Authors: Lalezari Iraj 
Published: April 2009

Abstractα‐Amino acids melted with ethyl or t‐butyl carbazate or, preferably, refluxed with t‐butyl carbazate in quinoline gave high yields of 3‐amino‐2,4‐imidazolidinediones (3‐aminohydantoins).
Imination of N‐methylazinium salts by liquid ammonia/potassium permanganate
Authors: Woźniak M. , Buurman D. J. , Van Der Plas H. C. 
Published: April 2009

AbstractTreatment of 1‐methylquinolinium‐, 1,4‐dimethylquinolinium‐ and 1‐methyl‐1,X‐naphthyridinium iodides (X = 5,8) with liquid ammonia/potassium permanganate leads to introduction of the imino group at C‐2 forming the 1,2‐dihydro‐2‐imino‐1‐methylquinolines and 1,2‐dihydro‐2‐imino‐1‐methyl‐1,X‐naphthyridines (X = 5,8) respectively. 1,2‐Dimethylquinolinium iodide, when subjected to treatment with liquid ammonia/potassium permanganate undergoes an oxo‐demethylation reaction, yielding 1‐methylquinol‐2‐one. The nmr‐measurements of solutions of the above‐mentioned salts in liquid ammonia clearly show the formation of a σ‐adduct, strongly suggesting that these σ‐adducts are intermediates in the imination reactions.
Molecular structure and 13C chemical shift assignments of 10‐(2′‐pyridyl)pyrido[3,2‐b][1,4]benzothiazine using 10‐phenylpyrido[3,2‐b][1,4]benzothiazine as the model compound
Authors: Jovanovic Misa V. , Biehl Edward R. , de Meester Patrice , Chu Shirley S. C. 
Published: April 2009

AbstractThe crystal structure of 10‐(2′‐pyridyl)pyrido[3,2‐b][1,4]benzothiazine, 6, shows that orientation of the 10‐pyridyl ring is in the plane bisecting the pyridobenzothiazine ring. This orientation is in contrast to that of 10‐(2′‐pyridyl)phenothiazine, 11, in which the heterocyclic ring is perpendicular to the plane bisecting the phenothiazine nucleus. X‐ray data also indicate that the resonance interaction between the lone pair of electrons of NSUB10 in 6 with either the pyridine protons of the tricylcic ring or the 10‐(2′‐pyridyl) ring is not significant. The folding angle of 166.1° in 6 is the largest observed for the pyridobenzothiazine ring. The nmr spectral assignments of the titled compound, 6, was accomplished using the structurally similar, 10‐phenylpyrido[3,2‐b][1,4]benzothiazine, 9, as the model compound. 10‐(2′‐Pyridyl)phenothiazine, 11, was shown to be an inadequate model for such assigments.
Ring transformation of 6H‐cyclopropa[e]pyrazolo[1,5‐a]pyrimidine. VI. Substituent effect of 6‐substituted 5a‐acetyl‐6a‐ethoxycarbonyl‐5a,6a‐ dihydro‐6H‐cyclopropa[e]pyrazolo[1,5‐a]pyrimidine‐3‐carbonitriles
Authors: Kurihara Takushi , Kawasaki Eiji , Morita Takamasa , Nasu Keiko 
Published: April 2009

AbstractSynthesis and reactivity of 6‐ethoxycarbonyl‐, 6‐phenyl‐ and 6‐methyl‐5a‐acetyl‐6a‐ethoxycarbonyl‐5a,6a‐di‐hydro‐6H‐cyclopropa[e]pyrazolo[1,5‐a]pyrimidine‐3‐carbonitriles 4, 5, and 7 are described.
The site‐selectivity of cycloadditions of nitrile oxides to β‐aminocinnamonitriles. A remarkable solvent dependence
Authors: Corsaro Antonino , Chiacchio Ugo , Perrini Giancarlo , Caramella Pierluigi , Purrello Giovanni 
Published: April 2009

AbstractCycloadditions of nitrile oxides to N‐mono and unsubstituted β‐aminocinnamonitriles are remarkably affected by the hydrogen acceptor ability of the solvent. Addition to C  N bond predominates in non and weak hydrogen bond acceptor solvents because of the assistance of favourable hydrogen bonding effects. In strong hydrogen bond acceptor solvents the assistance is fully relieved and the regular addition to C  C bond becomes prevalent.
Some cyclisation reactions of 2,2′‐disubstituted‐N‐arylpyrroles
Authors: Cheeseman G. W. H. , Eccleshall S. A. , Thornton T. 
Published: April 2009

AbstractTricyclic products were derived from N‐(2‐methoxycarbonylphenyl)pyrrole‐2‐carboxaldehyde (2) and N‐(2‐chloromethylphenyl)pyrrole‐2‐carboxaldehyde (8).
Convenient synthesis of 3‐arylazopyrazoles and 2‐arylazo‐1,3,4‐Δ2‐ thiadiazoline derivatives from 3‐nitroformazans
Authors: Abdelhamid Abdou O. , Abbas Ikhlass M. , Abdallah Magda A. , Fahmi Abdelgawad A. , Shawali Ahmad S. 
Published: April 2009

AbstractReactions of 3‐nitro‐1,5‐diarylformazans 1a‐c with carbanions of acetylacetone, dibenzoylmethane, aceto‐acetanilide, benzoylacetonitrile, ω‐benzenesulfonylacetophenone and malononitrile yielded the corresponding 3‐arylazopyrazole derivatives 4‐9 respectively. Reactions of 1 with nucleophiles result in displacement of the nitro group and the formation of the corresponding 3‐substituted formazans 10‐13. Treatment of 1 with potassium thiocyanate gave, however, 5‐imino‐2‐arylazo‐1,3,4‐Δ2‐thiadiazolines 14. Structural assignments have been made on the basis of spectral and elemental analyses, chemical behaviour and alternate synthesis wherever possible.
Studies on the synthesis of 2‐(2‐arylvinyl)thieno[2,3‐d]pyrimidines and 5‐(2‐arylvinyl)triazolothieno[3,2‐e]pyrimidines
Authors: Shishoo C. J. , Devani M. B. , Ullas G. V. , Ananthan S. , Bhadti V. S. 
Published: April 2009

AbstractSynthesis of 2‐(2‐arylvinyl)thienopyrimidines, by the acid catalyzed condensation of nitriles with thiophene o‐aminocarbonyl compounds, the condensation of aldehydes with thiophene o‐aminoamides, the base catalyzed condensation of aldehydes with 2‐methylthienopyrimidines and by the Wittig condensation of 2‐thieno‐pyrimidinylmethylphosphonium salts with aldehydes is described. Isomeric 5‐methyltriazolothienopyrimidines were found to react, under basic condition, with aldehydes yielding 5‐(2‐arylvinyl)triazolo[2,3‐c]thieno‐pyrimidines. While 5‐styryltriazolo[4,3‐c] isomers resisted acid catalysed isomerization, they were found to isomerize to triazolo[2,3‐c]pyrimidines under base catalysis.
Synthesis of (E)‐5‐oxo‐2‐(3‐α and 3β‐hydroxy‐1‐octenyl)‐1‐(4‐N‐pyrrolidine‐2‐butynyl)pyrrolidine
Authors: Zoretic P. A. , Khan R. H. , Caspar M. L. , Saltzman M. D. , Jardin J. 
Published: April 2009

AbstractThe synthesis of an oxotremorine analog, (E‐5‐oxo‐2‐(3α and 3β‐hydroxy‐1‐octenyl)‐1‐(4‐N‐pyrrolidino‐2‐butynyl)pyrrolidine, is reported.
Phosphorus pentoxide in organic synthesis. XIX. Mixtures of phosphorus pentoxide and ortho‐substituted arylamines as reagents in the synthesis of 9‐aryl‐9H‐purin‐6‐amines
Authors: El‐Bayouki Khairy A. M. , Nielsen Flemming E. , Pedersen Erik B. 
Published: April 2009

Abstract9‐Aryl‐9H‐purin‐6‐amines 2 were readily obtained by heating 5‐acetamido‐4‐amino‐2‐methylpyrimidin‐6(1H)‐one 1 in mixtures of phosphorus pentoxide, triethylamine hydrochloride and sterically hindered arylamines. Nonsterically hindered arylamines resulted in formation of 6‐arylaminopurines 3. The mechanism for rearrangement of 2 into 3 is discussed.
Synthesis of selenium analogs of glycerol from 1,2,3‐selenadiazoles
Authors: Ganjian I. , Lalezari I. 
Published: April 2009

AbstractA series of 1‐(2‐arylethynylselenomercapto)‐2,3‐epoxypropane and 1,3‐di(2‐arylethynylselenomercapto)‐2‐propanol were synthesized starting from 1,2,3‐selenadiazoles and epichlorohydrin.
Synthesis of indole derivatives from N‐alkenyl‐o‐chloroanilines with zero‐valent nickel complex
Authors: Rodriguez J. G. , Canoira L. 
Published: April 2009

AbstractReaction of N‐alkenyl‐o‐chloroanilines in toluene with tetrakis(triphenylphosphine)nickel (0) was carried out mainly to give indole and indoline derivatives in good yields. A detailed analysis of the reaction products has been done and it allows us to confirm the postulated mechanism of the cyclization reaction. Torsional hindrance around the NCCsp2 bond seems to prevent the cyclization reaction.
Reaction of 6‐phenyl‐2‐(p‐toluenesulfonyl)‐3(2H)pyridazinone with grignard reagents
Authors: Kashima Choji , Katoh Akira , Fukasawa Miyuki , Omote Yoshimori 
Published: April 2009

Abstract6‐Phenyl‐2‐(p‐toluenesulfonyl)‐3(2H)pyridazinone (I) reacted with Grignard reagents to give 5‐substituted 4,5‐dihydro‐3(2H)pyridazinones II and two types of dihydropyridazines, III and IV. The ratio of II, III, and IV was sensitively dependent on the reaction conditions. Further, by quenching the reaction mixture with alcohol, the ring‐opened product VII was mainly isolated.