bluuebunny/crossref_metadata_2025_split huggingface dataset:
Reversed changes of lipoxin A4 and leukotrienes in children with asthma in different severity degree
Authors: Wu Sheng‐Hua , Yin Pei‐Ling , Zhang Yong‐Mei , Tao Hui‐Xian 
Published: March 2010

AbstractObjectivesTo investigate the expressions of 15‐lipoxygenase (15‐LO) and 5‐lipoxygenase (5‐LO) in leukocytes and the changes of blood lipoxin A4(LXA4), leukotriene (LT)B4 and LTC4 in children with asthma, and to explore the relationship between the blood eicosanoids and one of serum high‐sensitivity C‐reactive protein (hsCRP), interleukin (IL)‐5, IL‐8 and IL‐13 and IgE in children with asthma.Study DesignOne hundred six asthmatic children were divided into three groups, that is, mild persistent asthmatic group, moderate persistent asthmatic group and severe persistent asthmatic group. Forty healthy children were served as controls.MethodologyThe expressions of 15‐LO and 5‐LO mRNA in leukocytes were assessed by reverse transcription‐polymerase chain reaction, and the blood LXA4, LTB4, LTC4, IL‐5, IL‐8, and IL‐13 were determined with enzyme‐linked immunosorbent assay. Serum hsCRP was determined with latex‐enhanced immuno‐turbidimetry kits.ResultsThe leukocytic 15‐LO expression and blood LXA4 were gradually decreased, and the leukocytic 5‐LO expression, blood LTB4, LTC4, IL‐5, IL‐8, IL‐13, and hsCRP were gradually increased in children with asthma from mild degree to moderate and severe degree. There were positive correlations between blood LXA4 and one of the peak expiratory flow (PEF) and forced expiratory volume in 1 sec (FEV1) percent‐predicted values, and negative correlations between blood LTC4 and one of the PEF and FEV1 percent‐predicted values in children with asthma. There were negative correlations between blood LXA4 and one of the IL‐5, IL‐8, IL‐13, and hsCRP levels, and positive correlations between one of blood LTB4, LTC4 and one of the IL‐5, IL‐8, IL‐13 and hsCRP levels in children with asthma.ConclusionsThe reversed changes between 15‐LO, its product LXA4 and 5‐LO, its products LTB4 and LTC4 in children with asthma from mild, moderate to severe degree were found, suggesting that insufficient generation of LXA4 and overproduction of LTs may be the reason for the asthmatic children whose illness become more serious. Pediatr Pulmonol. 2010; 45:333–340. © 2010 Wiley‐Liss, Inc.
The role of soil characteristics in the succession of two herbaceous lianas in a modified river floodplain
Authors: Asaeda T. , Rashid Md. H. , Kotagiri S. , Uchida T. 
Published: March 2010

AbstractThe Tamagawa floodplain of Japan experienced a series of changes in the structure of its plant community after 1960. Today, two dominant lianas – Pueraria lobata and Sicyos angulatus – have colonized the area and are competing for space. This study explores their competitive abilities in relation to soil factors and flooding disturbance downstream of the Tama River. Several colonies of these species were selected in three spots of the Tamagawa floodplain having different soil characteristics and flooding frequencies. Our results revealed that S. angulatus can only grow on fine sediment, whereas P. lobata can grow on soil with a wide range of particle sizes. Soil moisture and nitrogen requirements are higher for S. angulatus. S. angulatus grows only on fine sediment for two reasons: first, fine sediment stores a higher concentration of nitrogen and moisture; second, S. angulatus has a very shallow root system. P. lobata has an extensive root system with nodules, with which it can thrive on coarse and relatively dry soil with lower nitrogen. However, P. lobata requires higher soil phosphorus than S. angulatus does. The earlier patchy colonization of S. angulatus on the Tamagawa floodplain was provoked by flooding, when the perennial Miscanthus sacchariflorus and other species trapped fine sediments. Gradually, sediments became finer and nutrient‐rich due to vegetative decomposition, and S. angulatus invaded the area. The soil at that time was not deep enough for the root system of P. lobata. Subsequently, P. lobata outcompeted S. angulatus on the various types of soil that developed. Severe washing of fine substrates by floodwaters makes the area unsuitable for S. angulatus, whereas P. lobata continues to thrive. Copyright © 2010 John Wiley & Sons, Ltd.
Study of the morphology of NiO nanostructures grown on highly ordered pyrolytic graphite, by the Tougaard method and atomic force microscopy: a comparative study
Authors: Preda I. , Soriano L. , Alvarez L. , Méndez J. , Yubero F. , Gutiérrez A. , Sanz J. M. 
Published: March 2010

AbstractWe studied the morphology of the deposits of NiO grown on highly ordered pyrolytic graphite (HOPG), by means of inelastic peak shape analysis and atomic force microscopy. The results obtained by both techniques show an excellent agreement. The results indicate that NiO grows on HOPG by following the Stransky–Krastanov type of growth. Copyright © 2010 John Wiley & Sons, Ltd.
Superconducting properties of YBaCuO ceramic doped with Ca and Zn
Authors: Mahtali M. , Boudjema E. H. , Labbani R. , Chamekh S. , Bouabellou A. , Taoufik A. , Simon C. 
Published: March 2010

AbstractThe addition of elements as impurities to superconducting compounds generally varies their physical properties and more information on the possible mechanisms of superconductivity is obtained through impurity studies. It is known that the rare‐earth replacement of Y and Ba in YBaCuO superconductor (Y‐123) has a small effect on the superconducting transition temperature (with few elements proving to be an interesting exception). In contrast, the transition metal substitutions for Cu sites have a clear effect on Y‐123 properties. Impurities mainly substitute the Cu sites in the CuO chain (as Co) or in the CuO2 plane (as Zn). In this study, we investigate the effect of Ca and Zn substitutions on the structural, electrical and magnetic properties of a series of Y1−xCaxBa2(Cu0.98Zn0.02)3O7−δ ceramics. The Ca‐doped Y‐123(Zn) are prepared by conventional solid‐state reaction method and characterized by X‐ray diffraction (XRD),scanning electron microscopy (SEM), differential thermal analysis–thermogravimetric analysis (DTA–TGA), and electrical and magnetic measurements (magnetization; susceptibility). Copyright © 2010 John Wiley & Sons, Ltd.
X‐ray spectromicroscopy study of ubiquitin adsorption to plasma polymerized microstructures
Authors: Ceccone G. , Leung B. O. , Perez‐Roldan M. J. , Valsesia A. , Colpo P. , Rossi F. , Hitchcock A. P. , Scholl A. 
Published: March 2010

AbstractSynchrotron‐based X‐ray photoemission electron microscopy (X‐PEEM), atomic force microscopy (AFM), time of flight secondary ion mass spectrometry (ToF‐SIMS) and X‐ray photoelectron spectroscopy (XPS) have been used to visualize and characterize plasma polymerized acrylic acid (ppAA) and poly ethylene oxide (PEO)‐like microstructures. Micropatterned microstructures have been fabricated with electron‐beam lithography to obtain contrasted ppAA/PEO‐like structures. A surface area of 500 µm × 500 µm was patterned with arrays of 5 µm diameter circles and 500 µm × 5 µm lines. Samples have been analyzed before and after immersion of ubiquitin protein solutions. AFM and X‐PEEM results indicated that the protein adsorbed preferentially on the ppAA regions for both circular and line patterns. For both circular and line patterns, the protein preferentially adsorbed to the ppAA regions. Copyright © 2010 John Wiley & Sons, Ltd.
Seven and the sausage machine: Searching for conclusions in Miller's 1956 magical paper
Authors: Georgiou Ion 
Published: March 2010

AbstractThis paper offers an analytical review of Miller's classic paper of 1956 on ‘the magical number 7’. It takes account of that paper's contradictions as well as of its implicit conclusions. Miller's text is by no means clear in its logic or in its terms, and a review might be deemed helpful to those who are trying to understand it. The discussion begins with a brief historical overview. Miller's paper is then reviewed according to the order of the points made by Miller, thus facilitating a lucid comparative reading with that paper. Guidance on interpreting Miller's text is given throughout, leading to a number of technical conclusions. Finally, two general conclusions are offered, one which refers to the decision‐making literature, and one which refers more synoptically to science itself. Copyright © 2010 John Wiley & Sons, Ltd.
Non‐destructive, ‘in situ’, characterization of pigments in Minoan pottery at the stratigrafical museum of Phaistos (Crete)
Authors: Pappalardo L. , Pappalardo G. , Rizzo F. , Romano F. P. , La Rosa V. 
Published: March 2010

AbstractThis paper presents preliminary results of measurements of chemical composition of pigments on the Middle Minoan pottery coming from Festos and Hagia Triada excavations. The measurements were carried out ‘in situ’ with the use of the PIXE‐alpha spectrometer, with Po‐210 radioisotope as a source of sample excitation, built at Laboratorio Nazionale del Sud. The method of measurements is described in detail and the limits are discussed. The preliminary results confirm the use of the reduced iron technique to obtain the black slips and of the talc to produce the white ones. Similarly, the presence of Manganese in some orange pigments can be associated with the use of red ochre mixed to talc, the latter being used as whitening material. Copyright © 2010 John Wiley & Sons, Ltd.
Characterization of Indian Ayurvedic herbal medicines for their metal concentrations using WD‐XRF spectrometry
Authors: Swamy G. Y. S. K. , Ravikumar K. 
Published: March 2010

AbstractThis article describes the details of metal concentrations evaluated using wavelength dispersive X‐ray fluorescence (WD‐XRF) spectrometry. A total of 22 elements, Na, Mg, Al, Si, P, S, K, Ti, Ca, Cr, Mn, Fe, Ni, Cu, Zn, As, Cd, Hg, Pb, Ba, Au, and Sn from 16 Ayurvedic medicines were characterized. The method was validated by analyzing the six certified reference materials of soil standards [NIST SRM‐2710, CRM 027‐050 (US‐EPA certified), PS‐1, TILL‐1 and TILL‐4 (Canadian certified reference material, CCRMP) and JSO‐1 (Japanese certified reference material)]. The elemental concentrations in all the standards are found to be within ± 10% of the reported values. Crystalline phases in the individual drug samples were explained by powder X‐ray diffraction (XRD) technique. Qualitative phase identification was done using the ICDD database. Copyright © 2010 John Wiley & Sons, Ltd.
Die Zentrale-Orte-Systeme der Bundesländer
Authors: Stiens Gerhard , Pick Doris 
Published: March 2010

Eine schriftliche Umfrage der BfLR im Dezember 1997 bei den Ländern zu den jeweiligen Zentrale-Orte-Systemen (ZOS) erbrachte u.a. folgende Ergebnisse: Es bestehen sehr große Unterschiede zwischen den Bundesländern, was die Differenzierung derStufigkeit der Zentrale-Orte-Hierarchie und die Mindestbevölkerungszahlen für zentralörtliche Verflechtungsbereiche der verschiedenen Stufen anbelangt. Und bei der durchschnittlichen Erreichbarkeit der Oberzentren und Mittelzentren gibt es allein schon zwischen den alten Bundesländern erhebliche Unterschiede. Manche Länder schienen eher dieTragfähigkeit (d.h. die Träger) der Einrichtungen in den zentralen Orten im Auge gehabt zu haben, und bei anderen Länder scheint eher die Erreichbarkeit der Einrichtungen im Vordergrund gestanden haben.
Insgesamt sind die deutschenBundesländer für die Beibehaltung des Zentrale-Orte-Konzeptsin der Form eines integrierten Bestandteils des Systems landes-und regionalplanerischer Ziele und Instrumente. Doch werden Innovationen und eine Flexibilisierung der Anwendung für nötig erachtet. Eine Reihe von Ländern sieht im Zentrale-Orte-Konzept zudem einen unverzichtbaren Baustein für eine amPrinzip der Nachhaltigkeit ausgerichtete Siedlungsstrukturplanung.
Planungsprinzipien für eine nachhaltige Siedlungsentwicklung in Verdichtungsräumen
Authors: Hilligardt Jan 
Published: March 2010

Derzeit werden die Möglichkeiten der Konkretisierung des Leitbildes der nachhaltigen Entwicklung (Sustainable Development) auf breiter Basis diskutiert sowie erste Ansätze zur Umsetzung initiiert. Als eine besondere Herausforderung wird dabei auch das Aufgabenfeld nachhaltige Siedlungsentwicklung in Verdichtungsräumen gesehen. Bislang konnte jedoch in Wissenschaft und Praxis weder ein Konsens über die Definition noch über die Konkretisierung einer nachhaltigen Entwicklung bzw. einer nachhaltigen Siedlungsentwicklung für Verdichtungsräume erzielt werden.
Der vorliegende Beitrag gibt einen Ansatz zur Konkretisierung einer nachhaltigen Siedlungsentwicklung für Verdichtungsräume wieder. Diese Konkretisierung wird im Wege der Entwicklung von Planungsprinzipien unternommen, die bei der weiteren Siedlungsplanung in Verdichtungsräumen zu beachten sind, um zu einer nachhaltigen Siedlungsentwicklung zu kommen.
The Role of Socioeconomic Status in Interactions with Police Among a National Sample of Women Experiencing Intimate Partner Violence
Authors: Cattaneo Lauren Bennett 
Published: March 2010

AbstractUsing a national dataset of 820 women who had called the police for an incident of intimate partner violence, this study explored the relationship between several components of socioeconomic status (education, income, and employment), race, and the nature of interactions with police. Over and above the effects of control variables (the presence of an advocate on the scene, the severity of violence in the relationship, and prior calls to police), victims with higher education reported less positive interactions, less control during the interactions, and lower effectiveness of police. Race did not moderate these relationships, and the other components of socioeconomic status were not significantly related to any of the outcomes. Exploratory tests of mediation found that the relationship between education and the quality of interactions with police was explained by the fact that more educated victims felt they had less control in these incidents and were less likely to see the offender arrested. Results also provide evidence for the positive impact of advocates on interactions with police. Implications for research and policy are discussed.
Nuclear Power: Renaissance or Relapse? Global Climate Change and Long‐Term Three Mile Island Activists’ Narratives
Authors: Culley Marci R. , Angelique Holly 
Published: March 2010

AbstractCommunity narratives are increasingly important as people move towards an ecologically sustainable society. Global climate change is a multi‐faceted problem with multiple stakeholders. The voices of affected communities must be heard as we make decisions of global significance. We document the narratives of long‐term anti‐nuclear activists near the Three Mile Island (TMI) nuclear power plant who speak out in the dawn of a nuclear renaissance/relapse. While nuclear power is marketed as a “green” solution to global warming, their narratives reveal three areas for consideration; (1) significant problems with nuclear technology, (2) lessons “not” learned from the TMI disaster, and (3) hopes for a sustainable future. Nuclear waste, untrustworthy officials and economic issues were among the problems cited. Deceptive shaping of public opinion, nuclear illiteracy, and an aging anti‐nuclear movement were reasons cited for the lessons not learned. However, many remain optimistic and envision increased participation to create an ecologically‐balanced world.
Anxious Patients with Benign Scrotal Symptoms Achieve Excellent Reassurance from Imaging in a One-Stop Clinic
Authors: Barrass B.J.R. , Scurrell S. , Banerjee G. , Parry J.R.W. 
Published: March 2010

Objective: Testicular cancer is rare but anxiety about this possible diagnosis is common among men with scrotal symptoms. We prospectively evaluated patient reassurance and satisfaction provided by a dedicated one-stop testicular assessment clinic. Patients and Methods: 100 patients reporting scrotal symptoms attended the clinic and received a standardised clinical assessment, examination and scrotal ultrasound scan. At the end of the consultation patients completed a validated satisfaction, anxiety and reassurance questionnaire. Results: Overall patients were moderately anxious about their diagnosis (mean anxiety score 5/10) and 31% were highly anxious (anxiety score >7/10). Reassurance from the clinic was high with 90% expressing reassurance scores of 9/10 or greater and 96% expressing a satisfaction score of 9/10 or greater. Increased general anxiety predicted anxiety about the testicular diagnosis; however, when stratified by anxiety, the clinic was able to reassure men regardless of their baseline anxiety. Reassurance by the clinic appeared superior to primary care. Conclusion: These findings confirm anxiety is fairly common among men with testicular symptoms and a dedicated specialist one-stop testicular clinic provides a very high level of reassurance and satisfaction for these men.
Somatic mutation in the ACK1 ubiquitin association domain enhances oncogenic signaling through EGFR regulation in renal cancer derived cells
Authors: Chua Boon Tin , Lim Shu Jing , Tham Su Chin , Poh Wei Jie , Ullrich Axel 
Published: March 2010

Activated Cdc42‐associated Kinase, ACK1, is a non‐receptor tyrosine kinase with numerous interacting partners, including Cdc42 and EGFR. Gene amplification and overexpression of ACK1 were found in many cancer types such as those of the lung and prostate. Previously, we identified both somatic‐ and germ line missense mutations in the ACK1 coding sequence, by surveying 261 cancer cell lines and 15 control tissues. Here, we verified and characterized the non‐synonymous mutation, ACK‐S985 N, located in the ubiquitin association domain of the protein.Both overexpression and silencing experiments in MCF7 and A498 cells, respectively, demonstrated a role of the ACK1 S985 N mutation in enhancing cell proliferation, migration and anchorage‐independent growth as well as the epithelial–mesenchymal transition. Further, we showed that the ACK1 S985 N mutant is unable to bind ubiquitin, unlike the wild type kinase. This contributed to ACK1 protein stability and stabilized EGFR after EGF stimulation, thereby prolonging mitogenic signaling in cancer cells. In addition, the ACK1 S985 N‐EGFR interaction is enhanced, but not the ubiquitination of the receptor. Intriguingly, silencing of ACK1 in A498 cells sensitized the renal carcinoma cells to gefitinib, against which they are otherwise resistant.The work demonstrates that other than gene amplification, a single somatic mutation in ACK1 can result in extended protein stability enabling the oncoprotein to exert its oncogenic function in tumor progression. It also provides a rationale to target ACK1 in combination with other chemotherapeutic drugs, such as EGFR inhibitors, to potentiate therapeutic action against resistant tumors.
Fibre product approach to index pairings for the generic Hopf fibration of SUq(2)
Authors: Wagner Elmar 
Published: March 2010

AbstractA fibre product construction is used to give a description of quantum line bundles over the generic Podlés spheres obtained by gluing two quantum discs along their boundaries. Representatives of the corresponding K0-classes are given in terms of 1-dimensional projections belonging to the C*-algebra, and in terms of analogues of the classical Bott projections. The K0-classes of quantum line bundles derived from the generic Hopf fibration of quantum SU(2) are determined and the index pairing is computed. It is argued that taking the projections obtained from the fibre product construction yields a significant simplification of earlier index computations.
The Sparham Corpse Panels: Unique Revelations of Death from Late Fifteenth-Century England
Authors: Luxford Julian 
Published: March 2010

AbstractTwo late fifteenth-century rood-screen panels in Sparham church, near Norwich, display images of corpses that are apparently unique in surviving medieval art. One is painted with two standing corpses dressed in finery, the other with a corpse arising from a tomb within a church, with a font to one side. Both panels are notable for their surviving inscriptions, and others now lost. Together, these works constitute one of the most significant English contributions to the genre of death imagery, yet their uniqueness and artistic importance has not been recognized to date. Using a range of medieval and antiquarian sources, this article aims to provide a comprehensive account of the Sparham panels’ physical and historical context, iconography and meaning. The strong possibility that they functioned as a ‘surrogate sepulchral monument’ is discussed at the end of the paper.
IMPROVING THE DEVELOPMENT OF COFFEA ARABICA AFTER CHANGING THE PATTERN OF LEAF GAS EXCHANGE BY WATERING CYCLES
Authors: NOVAES PAULA , SOUZA JOÃO PAULO , ASSIS PRADO CARLOS HENRIQUE BRITTO 
Published: March 2010

SUMMARYHardening of Coffea arabica saplings by watering cycles (WCs) might be a suitable practice to achieve higher tolerance to low leaf water potential (Ψleaf) before transplanting to the field. As a consequence, hardening could promote growth and biomass gain during the initial development of C. arabica in the field. Thus, the less interrupted initial growth in a changing environment should confer higher flowering intensity in hardened than in control plants. The aim of this work was to verify if leaf gas exchange and Ψleaf behaviour of C. arabica saplings grafted on C. canephora showed consistent alterations during hardening by WCs and if this was effective to improve vegetative and reproductive growth under field conditions. For these reasons, saplings of the Mundo Novo cultivar of C. arabica grafted on C. canephora were submitted to seven WCs over 35 days. Each WC was completed when net photosynthesis was close to zero. The pattern of leaf gas exchange, mainly stomatal conductance (gs), was modified permanently after three WCs and the new pattern of leaf gas exchange could result in a more positive water balance and less interrupted development of C. arabica saplings in the field, particularly due to permanent low values of gs. After field transplantation, hardened plants showed greater height and stem diameter, more leaves and branches, and superior biomass production in leaves, stem and roots than control plants in dry and wet periods. The number of flowers was also significantly higher in hardened than in control plants. On the other hand, similar values were found between control and hardened plants in the leaf area ratio and the shoot/root ratio. Therefore, previous hardening by WCs was effective in improving leaf gas exchange, vegetative and reproductive development under field conditions and maintained the original biomass partitioning among the main plant compartments in dry and wet periods.
Determinants of the prevalence ofHeligmosomum costellatum(Heligmosomidae: Trichostrongyloidea) in a common vole population in southern Moravia, Czech Republic
Authors: Janova E. , Skoric M. , Heroldova M. , Tenora F. , Fictum P. , Pavlik I. 
Published: March 2010

AbstractA study of nematode (Heligmosomum costellatum) prevalence in the common vole (Microtus arvalis) population was performed in 2002 and 2003 in an agricultural region of southern Moravia, Czech Republic. The influence of the trapping date, body weight, age, gender and reproduction of the common vole on the prevalence of the larvae ofH. costellatumencapsulated in the stomach wall was examined. Of 503 common voles examined, 27.6% wereH. costellatumpositive. The prevalence ofH. costellatumin the common vole population was influenced mainly by the weight, trapping date, year and reproductive state, as well as by the interactions between year and gender and between year and reproductive state. The influence of age was weak. The most infected common vole groups were the older, heavier and already reproducing females captured from April to August and all voles captured in 2002. In general, parasite prevalence seems to be dependent on the population parameters of the host species. However, theH. costellatumprevalence study in a single common vole population was not sufficient to fully describe and explain the nematode–host interactions.