bluuebunny/crossref_metadata_2025_split huggingface dataset:
Nutritional Beliefs and Practices of Arabic-Speaking Middle Eastern Mothers Living in the United States
Authors: Al-Bkerat Maisaa , Martins Diane C. , Schwartz-Barcott Donna 
Published: May 2024

Introduction: Culture and acculturation influence nutritional beliefs. Little is known about the Arabic population in the United States. In this study, Arabic-speaking Middle Eastern mothers’ perceptions of motherhood and childhood nutritional beliefs and practices are explored. Method: Semi-structured interviews with 12 mothers from Arabic-speaking Middle Eastern countries. Results: Food and family are central to everyday life. Mothers worked hard to maintain traditional nutritional practices with their school-age children. Discussion: Findings can enhance school nurses’ ability to collaborate with mothers in nutritional education and address any issues in the classroom.
Involvement of circRNA Regulators MBNL1 and QKI in the Progression of Esophageal Squamous Cell Carcinoma
Authors: Wang Hai-Feng , Zhou Xiao-Feng , Zhang Qun-Mei , Wu Jie-Qing , Hou Jing-Han , Xu Xue-Lian , Li Xiu-Min , Liu Yu-Long 
Published: May 2024

Objectives To investigate the role of circRNA regulators MBNL1 and QKI in the progression of esophageal squamous cell carcinoma. Background MBNL1 and QKI are pivotal regulators of pre-mRNA alternative splicing, crucial for controlling circRNA production – an emerging biomarker and functional regulator of tumor progression. Despite their recognized roles, their involvement in ESCC progression remains unexplored. Methods The expression levels of MBNL1 and QKI were examined in 28 tissue pairs from ESCC and adjacent normal tissues using data from the GEO database. Additionally, a total of 151 ESCC tissue samples, from stage T1 to T4, consisting of 13, 43, 87, and 8 cases per stage, respectively, were utilized for immunohistochemical (IHC) analysis. RNA sequencing was utilized to examine the expression profiles of circRNAs, lncRNAs, and mRNAs across 3 normal tissues, 3 ESCC tissues, and 3 pairs of KYSE150 cells in both wildtype (WT) and those with MBNL1 or QKI knockouts. Transwell, colony formation, and subcutaneous tumorigenesis assays assessed the impact of MBNL1 or QKI knockout on ESCC cell migration, invasion, and proliferation. Results ESCC onset significantly altered MBNL1 and QKI expression levels, influencing diverse RNA species. Elevated MBNL1 or QKI expression correlated with patient age or tumor invasion depth, respectively. MBNL1 or QKI knockout markedly enhanced cancer cell migration, invasion, proliferation, and tumor growth. Moreover, the absence of either MBNL1 or QKI modulated the expression profiles of multiple circRNAs, causing extensive downstream alterations in the expression of numerous lncRNAs and mRNAs. While the functions of circRNA and lncRNA among the top 20 differentially expressed genes remain unclear, mRNAs like SLCO4C1, TMPRSS15, and MAGEB2 have reported associations with tumor progression. Conclusions This study underscores the tumor-suppressive roles of MBNL1 and QKI in ESCC, proposing them as potential biomarkers and therapeutic targets for ESCC diagnosis and treatment.
How and Why People Synchronize: An Integrated Perspective
Authors: daSilva Elizabeth B. , Wood Adrienne 
Published: May 2024

Academic Abstract Interpersonal synchrony, the alignment of behavior and/or physiology during interactions, is a pervasive phenomenon observed in diverse social contexts. Here we synthesize across contexts and behaviors to classify the different forms and functions of synchrony. We provide a concise framework for classifying the manifold forms of synchrony along six dimensions: periodicity, discreteness, spatial similarity, directionality, leader–follower dynamics, and observability. We also distill the various proposed functions of interpersonal synchrony into four interconnected functions: reducing complexity and improving understanding, accomplishing joint tasks, strengthening social connection, and influencing partners’ behavior. These functions derive from first principles, emerge from each other, and are accomplished by some forms of synchrony more than others. Effective synchrony flexibly adapts to social goals and more synchrony is not always better. Our synthesis offers a shared framework and language for the field, allowing for better cross-context and cross-behavior comparisons, generating new hypotheses, and highlighting future research directions.
Long peripheral catheters for intravenous infusions of iloprost or alprostadil therapy in rheumatologic outpatients
Authors: Donadoni Mattia , Calloni Maria , Romano Maria Eva , Mutti Alessandra , Bartoli Arianna , La Cava Leyla , Celano Rosita , Urso Francesco , Popescu Janu Valentina , Foschi Antonella , Casella Francesco , Taino Alba , Cogliati Chiara , Zappa Paolo , Masseroli Matteo Maria , Gidaro Antonio 
Published: May 2024

Background: Long peripheral catheters (LPCs) role in Difficult IntraVenous Access (DIVA) patients admitted to the emergency department has already been studied, resulting in a rapid, safe, and cost-effective procedure. Although their use in outpatient settings is established, there is a lack of studies assessing their benefits. In particular, rheumatologic outpatients affected by scleroderma, especially those affected by digital ulcers, are often treated with intravenous infusions of prostaglandin I2 (PGI2) analog (IV-PGI2A). Objective and methods: From 1 October 2021 to 31 March 2024, we conducted a prospective study enrolling DIVA outpatients affected by systemic sclerosis or undifferentiated connective tissue disease who needed IV-PGI2A therapy at L. Sacco Hospital in Milan (Italy). Each treatment cycle consisted of four consecutive days of infusion of iloprost or alprostadil. The primary aim was to assess the efficacy and potential complications associated with LPCs for IV-PGI2A. Results: Twenty-six patients were enrolled 23 were females (88.5%), and the median age was 72 years (IQR 56–78.7). In total, 97 LPCs were inserted, with a mean number of insertions per patient/year of 2.3. An increase in LPCs insertion during the 30 months of the enrollment period was observed. Eighteen patients required more than one LPC placement, and in 61% of them, the second venipuncture was executed at a different site. No procedural complications were registered (accidental puncture of the brachial artery, accidental median nerve puncture, bleeding) nor late complications (Catheter-Related Thrombosis, Catheter-Related Bloodstream Infections, Accidental Removal). Conclusions: Our experience shows that LPCs could be valuable and safe for rheumatologic outpatients. The increased number of insertions and new and total patients enrolled each year defines the satisfaction of patients and health care professionals.
Association Between Ki-67 Proliferative Index and Oncotype-Dx Recurrence Score in Hormone Receptor-Positive, HER2-Negative Early Breast Cancers. A Systematic Review of the Literature
Authors: Mooghal Mehwish , Khan Muhammad Ali Akbar , Samar Mirza Rameez , Shaikh Hafsa , Valimohammad Azmina Tajdin , Idrees Romana , Abdul Rashid Yasmin , Sattar Abida K 
Published: May 2024

Background: Oncotype-Dx (ODx) is a 21-gene assay used as a prognostic and predictive tool for hormone receptor (HR)-positive and human epidermal growth factor receptor 2 (HER2)-negative, node-negative, or 1 to 3 lymph node-positive early breast cancers (EBCs). The cost of the test, which is not available in low-middle income countries (LMICs), is not within the means of most individuals. The Ki-67 index is a marker of tumor proliferation that is cost-effective and easily performed and has been substituted in many cases to obtain prognostic information. Objective: We aimed to identify the correlation between the ODx recurrence score (RS) and the Ki-67 index in HR-positive EBCs and to determine whether Ki-67, like the ODx, can help facilitate clinical decision-making. Design: Systematic review correlating Ki-67 index and ODx in HR-positive and HER2-negative EBCs as per Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Data sources and methods: We searched different databases between January 2010 and May 2023 and included retrospective/prospective cohorts, clinical trials, case-control, and cross-sectional studies involving HR-positive and HER2-negative EBCs correlating the Ki-67 index and ODx RS categories. Results: Of the 18 studies included, 16 indicated a positive or weakly positive correlation between ODx and the Ki-67 index. The combined P value of the included studies is <0.05 ( P = .000), which shows a statistical significance between the 2. Our review also discusses the potential of machine learning and artificial intelligence (AI) in Ki-67 assessment, offering a cost-effective and reproducible alternative. Conclusion: Even although there are limitations, studies indicate a favorable association between ODx and the Ki-67 index in specific situations. This implies that Ki-67 can offer important predictive details, especially regarding the likelihood of relapse in HR-positive EBC. This is particularly significant in LMICs where financial constraints often hinder the availability of costly diagnostic tests.
Venous Stasis Ulceration due to Massive Splenomegaly Causing Iliac Vein Compression From Secondary Myelofibrosis
Authors: Dong Henry W. , Hernandez Lucille , Ghahremani Jacob S. , Chapek Michael A. , Safran Brent A. , Lau David L. , Brewer Michael B. 
Published: May 2024

Venous stasis ulcers are nonhealing lesions due to venous hypertension secondary to valvular dysfunction or deep venous outflow obstruction. We describe a case of a 71-year-old male with a history of polycythemia vera, secondary myelofibrosis, and massive splenomegaly up to 38 cm who presented with chronic, perimalleolar venous stasis ulcers and pain on the left lower extremity. CT showed significant compression of the left common iliac vein due to mass effect from the spleen. He was managed medically while being evaluated for partial splenic artery embolization but expired due to other chronic conditions before any intervention could be performed. Partial splenic artery embolization may be considered as a treatment option for patients with symptomatic iliac vein compression due to massive splenomegaly secondary to myelofibrosis, as long as extramedullary hematopoiesis is not compromised.
Timing of Surgery and Outcomes in Chronic Rhinosinusitis: A Narrative Review and Meta-Analysis
Authors: Bell Christopher M. , Yip Jonathan 
Published: May 2024

Background Surgery is often indicated in the treatment of medically recalcitrant chronic rhinosinusitis (CRS). There is conflicting evidence on the impact of timeliness of sinus surgery on the degree of perceived symptom improvement in CRS. Objective The goal of this study was to systematically evaluate the available literature on the relationship between patient wait times for endoscopic sinus surgery (ESS) and postoperative changes in patient-reported outcome measures. Methods Ovid, MEDLINE, CINAHL, and Cochrane Library of Systematic Reviews between January 2000 and September 1, 2023, were searched. A total of 931 studies were independently screened by 2 reviewers. Two studies were included in the meta-analysis, while 4 others were included in a narrative review. Results Two studies consisting of 1606 patients were included in the meta-analysis. A mean difference in 22-Item Sino-Nasal Outcome Test (SNOT-22) of −0.3 (95% CI = −3.9 to 3.3, I2 = 89%, P < .01 was observed between “long” and “short” groups, while a mean difference in SNOT-22 of −0.1 (95% CI = −2.5 to 2.3, I2 = 80%, P = .03) was observed between “long” and “mid” groups. Patients who receive surgery earlier on their disease process (ie, earlier from the time of diagnosis to eventual surgery) appear to require less access to healthcare resources including prescription medications, thus suggesting better disease control. Conclusion There is conflicting evidence to conclude whether timing of ESS affects disease-specific measures in patients with CRS. Patients who receive surgery earlier appear to have lower demands on healthcare utilization including visits and prescription use. Our study suggests there is a need for increased access to surgical specialists who manage patients with CRS, and better understanding by primary care specialists in how to manage CRS when specialist access is not available.
Longitudinal Associations Between Competition Contingent Self-Worth and Materialistic Values Among Chinese College Students: A Latent Growth Model
Authors: Yi Cong , Wei Jun , Liu Yanyan , Zheng Minglu 
Published: May 2024

This longitudinal study examined how the initial levels and change rates of competition contingent self-worth (CSW) predicted changes in materialistic values among college students during their first two college years. Participants were 948 students (607 females; M age = 18.61, SD age = .71 years, at Wave 1) from eight Chinese universities. Students’ competition CSW was measured annually across three waves, and their materialistic values were assessed at the last two waves. Latent growth analyses showed that Chinese college students generally experienced a mean-level decline in competition CSW from their freshmen to junior year. Students with higher initial levels or slower declining rates (or faster increasing rates) of competition CSW obtained greater increases in materialistic values over time. The results highlighted the potential role of competition CSW in contributing to the development of materialistic values among Chinese college students, which may pose threat to their well-being and comprehensive development in college.
Radiographic Alignment Parameters for Lumbosacral Reconstruction in Patients With Altered S1 Morphology
Authors: Patel Arpan A. , Srivatsa Shaarada , Greenberg Jacob K. , Pelle Dominic W. , Savage Jason W. , Steinmetz Michael P. , Spiessberger Alexander 
Published: May 2024

Study Design Retrospective quantitative analysis study. Objectives Pelvic incidence has been established as central radiographic marker which determines patient-specific correction goals during surgery for adult spinal deformity. In cases with sacral doming or sacral osteotomy where the PI cannot be calculated, reliable radiographic parameters need to be established to determine surgical goals. We aim to determine multiple radiographic parameters and formulas that can be utilized when the S1 superior endplate is obscured. Methods Retrospective analysis was performed on 68 healthy volunteers without prior spine surgery with full-length radiographs. Pelvic incidence, sacral slope, and pelvic tilt were calculated for each patient. Additional measurements such as L4, L5, and S2 incidence, tilt, and slope were collected. A new radiographic parameter defined as the L4-Sciatic notch angle was measured. Regression analysis was performed on each value to determine its relationship with S1 based incidence, tilt, and slope. Results Mean values for L5 incidence, L4 incidence, and L4 sciatic notch angle were 21.8° ± 8.9, 4.4° ± 8.1, and 44.4° ± 12, respectively. The linear regression analysis produced the following formulas which can be utilized to determine deformity correction goals when pelvic incidence can be calculated pre-operatively: L5i = .65*S1i–11.4, L4i = .44*S1i-18.6, and L4SNA = −.34*S1i + 66.5. In settings where pelvic incidence cannot be calculated, the following formulas can be utilized: L5i = .66*S2i-32.3 and L4SNA = −.02*S2i2 + 1.1*S2i + 63.5. P-values for all regression analyses were <.001. Conclusion This study provides target radiographic alignment values that can be utilized for patients with either pre-operative altered S1 endplates or in cases with intraoperative alteration of S1 (sacral osteotomy).
The influence of pain presence on pelvic floor and sexual dysfunctions, and pain intensity-related variables in women using the menstrual cup: A cross-sectional survey
Authors: Fuentes-Aparicio Laura , Cuenca-Martínez Ferran , Cortés-Amador Sara , Eroles-Tena Elena , Millán-González Coral , Sempere-Rubio Núria 
Published: May 2024

Objective: The aim was to assess the influence of pain during menstrual cup use on pelvic floor and sexual dysfunctions. In addition, we wanted to assess its impact on variables related to pain intensity during menstrual cup use such as insertion, removal, during menstruation, during sexual intercourse or the presence of pelvic pain. Methods: This study was a cross-sectional survey. The study included 566 women who fulfilled the inclusion criteria. Women were categorised into two primary groups: women with no pain and women with pain. Results: Regarding pelvic floor dysfunction, the independent samples t-test showed significant between-group differences ( t(564) = −3.50, mean differences (MD) = −8.86 (−13.8 to −3.89), p < 0.001). With respect to sexual dysfunction, no significant between-group differences were found with the exception of the pain subscale ( t(564) = 2.59, MD = 0.27 (0.48–0.06), p = 0.01. Regarding pain-related variables, we found statistically significant between-groups differences on all analysed variables. Conclusions: In conclusion, the results showed that women who use the menstrual cup and have pain showed worse scores on the pelvic floor dysfunction questionnaire, where it also seems that greater pain intensity was associated with worse questionnaire scores. However, we found no significant differences in sexual dysfunction except for the pain subscale between women who did and did not report pain in menstrual cup use. Finally, women who reported pain from menstrual cup use showed significantly greater pain intensity when inserting and removing the menstrual cup, during menstruation, during sexual intercourse and showed higher levels of pelvic pain although these differences are clinically slight.
Understanding dentatorubral-pallidoluysian atrophy (DRPLA) symptoms and impacts on daily life: a qualitative interview study with patients and caregivers
Authors: Contesse Marielle G. , Woods Rebecca J. , Leffler Mindy , Prades Silvia , Greenfield Julie , Compton Andrea , Carroll Jeffrey B. 
Published: May 2024

Background: Dentatorubral–pallidoluysian atrophy (DRPLA) is a rare, neurodegenerative disorder with no disease-modifying treatments. There is a dearth of information in the literature about the patient and caregiver experience living with DRPLA. Objectives: This study aimed to (1) understand symptoms experienced by adult- and juvenile-onset DRPLA populations and their impact on daily life and (2) explore patient and caregiver treatment goals and clinical trial participation preferences. Design: The study was a qualitative interview study. Methods: Interviews were conducted remotely with adult patients with DRPLA and caregivers. Participants described patient symptoms and the impact of those symptoms on daily life, and they discussed treatment goals and potential clinical trial participation. There were 18 patients described in the interviews with two patients and seven caregivers. Some participants were caregivers to multiple patients with DRPLA. Results: Interview transcripts were coded for themes, and reported symptoms were summarized with descriptive statistics. Adult-onset patients ( N = 7) experienced difficulty with ataxia (100%), cognition (100%), fine motor skills (100%), gross motor skills (100%), speech (100%), personality changes (100%), and seizures (57%). Juvenile-onset patients ( N = 11) experienced difficulty with ataxia (100%), sleep (100%), speech (100%), jerking/twitching (83%), behavior (82%), cognition (82%), fine motor skills (82%), gross motor skills (82%), sensory sensitivity (75%), and seizures (64%). When considering aspects of DRPLA to target for future treatment, patients prioritized ataxia/mobility (100%), juvenile-onset caregivers prioritized ataxia/mobility (60%) and independence (60%), and adult-onset caregivers prioritized personality (60%). Almost all patients (93%) would participate in a clinical trial if given the opportunity, but travel to a clinical site could pose a participation barrier for half. Conclusion: This study found that there are symptom domains that are relevant across the DRPLA population, but there is heterogeneity within each domain based on the age of symptom onset and disease stage, which has implications for clinical trial design.
Arthroscopic Medial Meniscal Root Repair Using a Novel Re-Tensionable All-Suture Anchor
Authors: Szukics Patrick , Robaina Jose , Ravich Jonas W. , Vargas Luis A. , Yagnik Gautam 
Published: May 2024

Background: Medial meniscal root repairs are devastating injuries that can cause long-term knee problems if not properly addressed. Some common issues when addressing these injuries surgically include the “bungee-cord” effect seen with implants that sit too far from the tibial plateau surface and loss of tension on the sutures after cycling of the knee after the repair. This video will discuss the presentation of a patient with a medial meniscal root repair treated with a novel technique to counteract these aforementioned issues. Indications: Based on the patient’s medial meniscal root tear and minimal arthritis seen on radiograph, he was indicated for a meniscal root repair to prevent meniscal extrusion and reinforce normal meniscal hoop stresses to limit progression of his arthritis. Technique Description: This technique uses a novel re-tensionable all-suture anchor through a transtibial tunnel with 2 repair sutures through the meniscal root that sits just below the tibial plateau, allowing the surgeon the ability to re-tension the implant after cycling the knee. Results: Arthroscopic repair of the medial meniscal root allowed the patient to return to his previous level of activity. Discussion/Conclusion: In this case, arthroscopic medial meniscal root repair can yield good results in patients to get them back to their previous level of activity while minimizing the chance of rapid arthritic progression that is typically seen with nonoperative management of these injuries. Patient Consent Disclosure Statement: The author(s) attests that consent has been obtained from any patient(s) appearing in this publication. If the individual may be identifiable, the author(s) has included a statement of release or other written form of approval from the patient(s) with this submission for publication.