bluuebunny/crossref_metadata_2025_split huggingface dataset:
ECPELLA as a bridge-to-decision in refractory cardiogenic shock: a single-centre experience
Authors: Balder Jan-Willem , Szymanski Mariusz K. , van Laake Linda W. , van der Harst Pim , Meuwese Christiaan L. , Ramjankhan Faiz Z. , van der Meer Manon G. , Hermens Jeannine A. J. M. , Voskuil Michiel , de Waal Eric E. C. , Donker Dirk W. , Oerlemans Marish I. F. J. , Kraaijeveld Adriaan O. 
Published: May 2024

Abstract
Background
In refractory cardiogenic shock, temporary mechanical support (tMCS) may be crucial for maintaining tissue perfusion and oxygen delivery. tMCS can serve as a bridge-to-decision to assess eligibility for left ventricular assist device (LVAD) implantation or heart transplantation, or as a bridge-to-recovery. ECPELLA is a novel tMCS configuration combining venoarterial extracorporeal membrane oxygenation with Impella. The present study presents the clinical parameters, outcomes, and complications of patients supported with ECPELLA.

Methods
All patients supported with ECPELLA at University Medical Centre Utrecht between December 2020 and August 2023 were included. The primary outcome was 30-day mortality, and secondary outcomes were LVAD implantation/heart transplantation and safety outcomes.

Results
Twenty patients with an average age of 51 years, and of whom 70% were males, were included. Causes of cardiogenic shock were acute heart failure (due to acute coronary syndrome, myocarditis, or after cardiac surgery) or chronic heart failure, respectively 70 and 30% of cases. The median duration of ECPELLA support was 164 h (interquartile range 98–210). In 50% of cases, a permanent LVAD was implanted. Cardiac recovery within 30 days was seen in 30% of cases and 30-day mortality rate was 20%. ECPELLA support was associated with major bleeding (40%), haemolysis (25%), vascular complications (30%), kidney failure requiring replacement therapy (50%), and Impella failure requiring extraction (15%).

Conclusion
ECPELLA can be successfully used as a bridge to LVAD implantation or as a bridge-to-recovery in patients with refractory cardiogenic shock. Despite a significant number of complications, 30-day mortality was lower than observed in previous cohorts.
Design of Novel Saposin-like Bacteriocins Using a Hybrid Approach
Authors: Oftedal Thomas F. , Diep Dzung B. , Kjos Morten 
Published: May 2024

AbstractA multitude of approaches will be required to respond to the threat posed by the emergence and spread of antibiotic resistant pathogens. Bacteriocins have gained increasing attention as a possible alternative to antibiotics, as such peptide antimicrobials have mechanisms of action different from antibiotics and are therefore equally potent against antibiotic resistant bacteria as their susceptible counterparts. A group of bacteriocins known as saposin-like bacteriocins is believed to act directly on the bacterial membrane. Based on seven saposin-like leaderless bacteriocins, we have constructed a library of hybrid peptides containing all combinations of the N- and C-terminal halves of the native bacteriocins. All hybrid peptides were synthesized using in vitro protein expression and assayed for antimicrobial activity towards several pathogens. Of the 42 hybrid peptides, antimicrobial activity was confirmed for 11 novel hybrid peptides. Furthermore, several of the hybrid peptides exhibited altered antimicrobial spectra and apparent increase in potency compared to the peptides from which they were derived. The most promising hybrid, termed ISP26, was then obtained synthetically and shown to inhibit most of the Gram-positive species tested, including opportunistic pathogens and food spoilage bacteria. Additionally, ISP26 was shown to inhibit Acinetobacter, a species of Gram-negative bacteria frequently isolated from nosocomial infections. The activity of the hybrid library provides valuable insights into the design and screening of new active bacteriocins.
The regulation of hypoxia-related lncRNAs in hepatocellular carcinoma
Authors: Wang Xuejing , Wang Xiaojun 
Published: May 2024

AbstractHepatocellular carcinoma (HCC) is still a public health disease with its high prevalence and morbidity. Short of early diagnosis biomarkers and effective therapy, the treatment of HCC patients hasn’t achieved ideal effect. Hypoxia is a hallmark of HCC, which is mainly induced by imbalance of tumor cell proliferation and insufficient supply of oxygen. Recently, amounting evidence suggested lncRNAs, especially hypoxia-related lncRNAs play a pivotal role in regulating HCC. Hypoxia-related lncRNAs are involved in altering glucose metabolism, maintaining of cancer stem cell-like properties (CSCs), cell apotosis, proliferation and immune escape, which all contribute to the poor prognosis of HCC patients. The novel identified hypoxia-related lncRNAs could be the potential target or biomarkers of HCC, which are beneficial to the clinical treatment. Herein, we summarized currently reported hypoxia-related lncRNAs and their related mechanisms, providing potential application and future perspective of hypoxia-related lncRNAs as a potential therapeutic target.
A snapshot on current approaches to lymphadenectomy in liver resection for intrahepatic cholangiocarcinoma: results from an international survey
Authors: Sposito Carlo , Maspero Marianna , Cucchetti Alessandro , Mazzaferro Vincenzo 
Published: May 2024

AbstractThe use of lymphadenectomy (LND) during resection of intrahepatic cholangiocarcinoma (ICC) is still debated, leading to differing practices in different centers and countries. The aim of this study was to assess such differences. A survey on LND for ICC was distributed to the members of the International Hepato-PancreatoBiliary Association (IHPBA) and the Italian Chapter of IHPBA (AICEP). Two-hundred thirty-four surgeons completed the survey (88% males; median age 46 years). Preoperative nodal staging was deemed mandatory/very important by 65%. Adequate LND was defined as hepatoduodenal ligament LND by 33%, LND at specific nodal stations by 28% and retrieval of > 5 nodes by 28%. The decision to perform LND was influenced by comorbidities (48%), chronic liver disease (38%) and satellitosis (32%). Most participants modify perioperative management in case of clinically positive nodes, 50% stating they would give neoadjuvant therapy. The role of LND in clinically node negative disease was adequate staging for 88%, survival benefit for 50.5% and clinical trials eligibility for 18.5%. Our survey confirms heterogeneity in the evaluation of role and extent of LND for ICC, how this relates to subjective perception of importance of LND, and need of a systematic approach in this area.
A comprehensive study on the effect of small rates of walnut shell and talc fillers on the thermal,mechanical, and morphological properties of epoxy hybrid composites
Authors: Karagöz İdris , Mutlu Derya , Çavuşoğlu Aysu , Çelebi Mithat , Ceylan Özgür 
Published: May 2024

AbstractEpoxy-based composites, valued for their cost-effectiveness and remarkable mechanical properties, attract considerable attention from researchers in academia and industry. This study explores the impact of low concentrations (1% to 3%) of walnut shell (WS) and talc additives on the density, water absorption, and mechanical (tensile, three-point bending, impact, hardness) as well as thermal (TGA, DSC) properties of epoxy composites. While prior research has extensively covered epoxy composites with high concentrations of walnut shell and talc, their utilization in lower concentrations remains underexplored. Findings highlight the substantial influence of incorporating low percentages of walnut shell and talc on the Tg temperatures of epoxy composites, with talc reducing Tg temperature and WS elevating it. TGA tests reveal that both WS and talc contribute to increased Tmax temperature and residue content compared to pure epoxy. Mechanical properties exhibit variations based on filler type and amount, with walnut shell enhancing the elastic modulus and talc decreasing it compared to pure epoxy. Impact resistance sees significant reductions related to particle size. Talc boosts density, while WS has a more pronounced effect on hardness. Water absorption tests demonstrate higher water absorption in WS-containing epoxy composites. Glossiness and surface roughness undergo changes, with talc increasing roughness and decreasing glossiness. In conclusion, even minor filler percentages noticeably impact epoxy composite properties compared to pure epoxy, providing avenues for customized modifications, particularly with challenging or costly fillers, offering viable alternatives for researchers in diverse fields.
Topology optimization of AISI 4140 steel with surface texture filled by multi-solid lubricants for enhancing tribological properties
Authors: Huang Qipeng , Wu Chaohua , Shi Xiaoliang , Zhang Kaipeng 
Published: May 2024

AbstractWind power gears will be excessively worn due to lubrication failure during operation. Herein, the tribological properties of rubbing pairs are improved by filling solid lubricants into surface texture. In texture design, three types of topological textures (Circle (C), Hexagon (H) and Circle/Hexagon (CH)) were obtained by cell topology optimization, and then three cases with 20%, 30%, and 40% density were designed for each texture. Next, SnAgCu and TiC were deposited in texture of AISI 4140 steel (AS) to obtain 9 kinds of self-lubricating surfaces. Among them, AS with 30% CH density (AS-CH30) exhibits excellent mechanical and tribological properties. Compared with AS-C and AS-H, the maximum equivalent stress of AS-CH was decreased by 10.86% and 5.37%, respectively. Friction coefficient and wear rate of AS-CH30 were 79.68% and 78% lower than those of AS. The excellent tribological performances of AS-CH30 can be attributed to the synergistic effect of topological surface and solid lubricants. Topological surface can not only reduce fluctuation of equivalent stress, but also promote the stored lubricants to be easily transferred at the contact interface to form a 200 nm lubricating film containing solid lubricants (mainly), oxides and wear debris.
A Latent Profile Analysis of COVID-19 and Influenza Vaccine Hesitancy among Economically Marginalized Hispanic Mothers of Children under Five Years of Age in the US
Authors: Park Yea Won , Bragard Elise , Madhivanan Purnima , Fisher Celia B. 
Published: May 2024

AbstractRates of COVID-19 and influenza vaccine coverage among Hispanic young children continue to be low in comparison to other racial and ethnic groups in the United States. This study utilized a person-centered approach to understand COVID-19 and influenza vaccination hesitancy for young children under the age of five among 309 economically marginalized Hispanic mothers. Drawing on the cultural health belief model, in 2022, following FDA approval of the COVID-19 vaccine for young children, a latent profile analysis was conducted from which three profiles emerged. The Low Acculturation group (Profile 1), was notable for lower acculturation, moderate cultural medical mistrust, lower access to vaccines, and higher financial security. Compared to Profile 1, the two remaining profiles had higher acculturation and lower levels of financial security, but differed in that the High Acculturation group (Profile 2) had higher vaccine accessibility and the Moderate Acculturation group (Profile 3) had higher cultural medical mistrust. Relative to other profiles, Low Acculturation mothers were more likely to plan to vaccinate their child against current and seasonal COVID-19 and seasonal influenza, report that their child’s health provider recommended the COVID-19 shot and reported lower COVID-19 and influenza vaccine mistrust. However, they also reported lower vaccine accessibility and moderate levels of cultural medical mistrust. The study highlights the importance of developing person-centered public health strategies that draw on Hispanic cultural values and consider diversity within lower income Hispanic populations to increase future pediatric COVID-19 and flu vaccination coverage among young Hispanic children.
The German guideline on medical clinical diagnostics for indoor mold exposure: key messages
Authors: Hurraß Julia , Wiesmüller Gerhard A. 
Published: May 2024

AbstractThe AWMF S2k guideline “Medical clinical diagnostics for indoor mold exposure” was introduced in 2016. The guideline is based on a standardized procedure of the AWMF including a systematic literature search involving several medical disciplines. The expert group has updated this guideline in accordance with AWMF specifications. For this purpose, a new Medline search was carried out for the current version of the guideline up to June 2022 with additional search terms. The search results were evaluated and further narrowed down by means of abstract screening and, where applicable, evidence-based evaluation of the full texts. Medical guidelines on related topics were also taken into account. The updated guideline is available since October 2023. This is intended to close the existing knowledge gap for rational and efficient medical diagnostics for indoor mold contamination and provides 26 core statements and recommendations, which are presented in detail.
A Bibliometric Review of Reinforced Soil Wall Research Topics
Authors: Malekmohammadi Khashayar , Damians Ivan P. 
Published: May 2024

AbstractReinforced soil or mechanically stabilized earth (MSE) wall structures offer straightforward construction techniques as an alternative to conventional retaining earth walls. The benefits of MSE wall structures are their low cost, rapid construction, minimal ground occupation, and high tolerance for differential settlements. In the past, a vast amount of research has been conducted on this specific topic, but there is no state-of-the-art overview on the general reinforced soil walls subject. In this paper, a bibliometric review of MSE walls literature is carried out to provide multiple data points regarding the state-of-the-art in MSE wall publications. To present/demonstrate the main traditional applications, current utility, and last developments of MSE walls, a thematic/keyword cluster categorization is performed to catalog and organize the numerous applications analyzed and published in the last 4 decades. Furthermore, a discussion of MSE wall characteristics is conducted to assist researchers in expanding their understanding of potential future research areas.
In situ build surface topography determination in electron beam powder bed fusion
Authors: Renner Jakob , Markl Matthias , Körner Carolin 
Published: May 2024

AbstractElectron optical imaging is the most promising process monitoring method in electron beam powder bed fusion. State of the art in modern machines is the installation of a single detector in the top center of the build chamber. Exemplary applications are the reconstruction of digital twins of manufactured parts to compare their dimensional accuracy or analysing the top surface of each layer to identify surface features like pores or material transport. Multi-detector systems are currently under research and have shown great potential in reconstructing the surface topography in situ. A recently developed ray tracing model, describing the image formation process, allows to formulate design guide lines for multi-detector systems and provides a method for the computation of the normal vector field of the build surface. This work utilizes the recent progress and presents a newly developed four-detector system and an updated computation chain, which enable build surface topography reconstruction in situ in every layer of a build process. The computation chain contains a normal integration algorithm, which employs Tikhonov regularization to cope with measurement irregularities. The integration method is validated with ex situ measured as-built surfaces. Additionally, first applications are demonstrated and connections to process parameter changes illustrated.
Behavioral Sleep Interventions for Children with Rare Genetic Neurodevelopmental Conditions: A Retrospective Analysis of Overall Outcomes for 26 Cases
Authors: Woodford Emma C. , France Karyn G. , Blampied Neville M. , Hanning Ursula , Swan Catherine E. , McLay Laurie K. 
Published: May 2024

Abstract
Objectives
Sleep difficulties are highly prevalent among children with rare genetic neurodevelopmental conditions (RGNC) such as Angelman and Smith-Magenis syndromes. Behavioral interventions are commonly used in the treatment of sleep difficulties in children; however, research is limited in children with RGNC. This study evaluated the overall effectiveness and acceptability of function-based behavioral sleep interventions for children with RGNC.

Methods
Data was collated from a series of experimental single-case research studies with 26 children (18 months to 19 years of age) with a range of RGNC, who received a behavioral sleep intervention. Intervention strategies included circadian (e.g., sleep/wake rescheduling), antecedent (e.g., sleep hygiene), and/or consequence (e.g., positive reinforcement of sleep-conducive behavior and modified extinction) modifications implemented by parents. Clinicians provided support for parents mostly via telehealth methods. Overall outcomes were examined using modified Brinley plots and effect size estimates. The effect of age, gender, and a range of psychological variables on intervention response was also examined.

Results
Improvements in sleep problem severity were observed for 24/26 participants, and gains were maintained at long-term follow-up for 13/16. Interestingly, 50% of the children achieved clinically significant change with less restrictive strategies (e.g., circadian, antecedent and positive reinforcement strategies), suggesting extinction procedures may be used as the last option in a sequence of interventions. Parents generally perceived interventions to be acceptable. There was minimal evidence of any differential response to intervention as a function of age, gender, or psychological variables.

Conclusions
Results suggest function-based behavioral interventions offer an effective and socially valid method for treating sleep disturbance in children with RGNC.
La révolution de l’IRM prostatique
Authors: Bacchetta Frédéric , Roth Beat , Martel Paul 
Published: May 2024

RésuméDépister le cancer de la prostate, connu pour sa cinétique généralement lente et son apparition tardive a longtemps questionné sur son utilité de santé publique. Si la mesure du PSA associée à des biopsies aléatoires a permis de réduire graduellement la mortalité, au prix d’un surdiagnostic et d’un surtraitement excessif, la qualité du diagnostic a beaucoup progressé avec l’utilisation de l’IRM. La détection inutile de formes indolentes est efficacement limitée en parallèle d’un net gain en précision diagnostique, permettant de réserver les traitements aux situations de nécessité. Cet article résume l’évolution d’une discipline longtemps critiquée, ayant trouvé avec l’IRM une réponse technique à la problématique du dépistage.
Effect of SiC addition on laser-based CoNi binary alloy coatings on Ti-6Al-4V alloy
Authors: Adesina Olanrewaju Seun , Popoola Abimbola Patricia , Farotade Gabriel Ayokunle , Obadele Babatunde Abiodun , Sanyaolu Olufemi Oluseun , Jeje Samson Olaitan , Rominiyi Azeez Lawan 
Published: May 2024

AbstractThis research explores the impact of variations in laser scanning speed and the incorporation levels of SiC-Ni-Co powders on Ti-6Al-4V alloy using laser surface cladding technique. Key parameters, including a consistent laser power of 700 W, a 4 mm beam spot size, a powder feed rate of 1.0 g/min, and a gas flow rate of 3 L/min, along with fixed powder compositions, were maintained. The laser scanning speeds were adjusted to 0.4 m/min, 0.8 m/min, and 1.2 m/min. Microstructural analyses were carried out using scanning electron microscopy (SEM) while Vickers microhardness was employed to assess coating hardness, and corrosion properties were evaluated using a linear potentiodynamic polarization technique. Following the corrosion attack, the protective oxides formed were identified through SEM and X-ray diffractometer (XRD). The results revealed a strong metallurgical relationship between the clad layer and the substrate, demonstrating the effectiveness of the laser-clad technique. Particularly, the highest laser scan speed exhibited the most significant improvements in hardness and corrosion resistance. The coatings displayed an average hardness value of 1269.20 HV0.1, a notable fourfold increase compared to the substrate's value of 334 HV0.1. Concerning corrosion, a clear correlation emerged between scan speed and polarization resistance, confirming that higher scan speeds could lead to enhanced polarization resistance.
Optimization of different drying methods and its impact on antioxidant potential of Ocimum basilicum L.
Authors: Bhatt Sunita , Tewari Geeta , Bisht Mamta , Aabha  , Pande Chitra , Kanyal Bhawana , Rani Akansha 
Published: May 2024

AbstractIn the present study, the effect of different drying methods (sun drying, shade drying, oven drying at 35 °C, 45 °C, 55 °C and hot air blower drying) was assessed to optimize the essential oil (EO) quality of Ocimumbasilicum L. The fresh and dried samples were hydrodistilled using a Clevenger apparatus to extract the EO. The EO composition was determined by GC and GC–MS techniques. The antioxidant activity was measured using 2, 2- diphenyl-1-picrylhydrazyl (DPPH) radical scavenging activity; FRAP activity and Fe2+- ferrozine test system for iron chelating activity methods. The content of iron, copper, zinc and manganese were analyzed by Atomic Absorption Spectrophotometer (AAS). Sun dried O.basilicum showed the highest EO yield (0.8%, v/w). Linalool (10.67–32.91%) and methyl chavicol (16.24–58.00%) were present as the major components in all the EOs being the highest for blower dried and shade dried samples respectively. EO obtained from the shade dried material was showing the highest antioxidant potential followed by blower dried plant sample. Dried material exhibited higher micronutrient content as compared to the fresh one. The shade drying method can be a good option for obtaining the best quality essential oil from O.basilicum in terms of the major component and antioxidant potential.
Use of aquaculture wastewater in the cultivation of cactus pear as an alternative for semi-arid regions
Authors: Pedrosa Talita Dantas , Batista Rafael Oliveira , Dombroski Solange Aparecida Goularte , de Medeiros José Francismar , de Oliveira Palloma Vitória Carlos , de Melo Rafael Rodolfo , Portela Jeane Cruz 
Published: May 2024

AbstractThe objective was to characterize the dilutions of aquaculture wastewater in supply water and the morphometric and productive characteristics of the cactus pear. The experiment was installed at the Water Reuse Experimental Unit in Mossoró-RN, a Semi-Arid region of Brazil. The design was in randomized blocks with five treatments and five replications, being (D1—100% supply water; D2—75% supply water and 25% aquaculture wastewater; D3—50% supply water and 50% aquaculture wastewater; D4—25% supply water and 75% aquaculture wastewater; and D5—100% aquaculture wastewater). The physical–chemical characterization of the dilutions and the evaluation of the palm production and development parameters were carried out. The occupied area (Aop), the fresh volume of aerial phytomass (Vf), and the fresh weight of the aerial phytomass produced by the forage cactus (Pf) were estimated. The proportion of 75% aquaculture wastewater and 25% supply water provided the lowest average value for plant height in the analysis carried out over time and 365 days after planting. Variations in dilutions of aquaculture wastewater in supply water did not provide any difference in the plant's moisture content. Replacing supply water with aquaculture wastewater by up to 25% allowed productivity-like control.