bluuebunny/crossref_metadata_2025_split huggingface dataset:
Very Long-Term (15 to 20 Years) Clinical and Angiographic Outcome After Coronary Bare Metal Stent Implantation
Authors: Yamaji Kyohei , Kimura Takeshi , Morimoto Takeshi , Nakagawa Yoshihisa , Inoue Katsumi , Soga Yoshimitsu , Arita Takeshi , Shirai Shinichi , Ando Kenji , Kondo Katsuhiro , Sakai Koyu , Goya Masahiko , Iwabuchi Masashi , Yokoi Hiroyoshi , Nosaka Hideyuki , Nobuyoshi Masakiyo 
Published: September 2010

Background—
We previously reported that the long-term luminal response after coronary bare metal stenting is triphasic, with an early restenosis phase spanning the 6 months after the index procedure, an intermediate-term regression phase from 6 months to 3 years, and a late renarrowing phase beyond 4 years. However, the clinical significance of late luminal renarrowing remains unknown.

Methods and Results—

Angiographic and clinical follow-up of the same cohort of 405 patients with successful Palmaz-Schatz stent placement was extended beyond 15 years. Clinical follow-up was completed in 98% of patients at 5 years and in 81% at 15 years. The incidence of death and cardiac death at 15 years was 45.4% and 20.6%, respectively. Paired long-term (4 to 10 years) and very long-term (>10 years) angiographic studies without intercurrent target lesion revascularization were performed in 55 lesions, and minimal luminal diameter further decreased from 1.88±0.50 mm to 1.60±0.73 mm (
P
=0.002). Late target lesion revascularization after initial stabilization of the stented segments occurred rarely within 4 years. Beyond 4 years, however, the incidence of late target lesion revascularization increased steadily from 3.3% at 4 years to 24.7% at 15 years. The incidence of definite very late stent thrombosis was low (1.5% at 15 years).

Conclusions—
Luminal renarrowing of the stented segment beyond 4 years was a progressive process extending beyond 10 years. The angiographic observation of late in-stent restenosis was clinically relevant because a corresponding progressive increase in the incidence of late target lesion revascularization was observed beyond 4 years and up to 15 to 20 years after bare metal stent implantation.
Prophylactic Implantable Defibrillator in Patients With Arrhythmogenic Right Ventricular Cardiomyopathy/Dysplasia and No Prior Ventricular Fibrillation or Sustained Ventricular Tachycardia
Authors: Corrado Domenico , Calkins Hugh , Link Mark S. , Leoni Loira , Favale Stefano , Bevilacqua Michela , Basso Cristina , Ward Deirdre , Boriani Giuseppe , Ricci Renato , Piccini Jonathan P. , Dalal Darshan , Santini Massimo , Buja Gianfranco , Iliceto Sabino , Estes N.A. Mark , Wichter Thomas , McKenna William J. , Thiene Gaetano , Marcus Frank I. 
Published: September 2010

Background—
The role of implantable cardioverter-defibrillator (ICD) in patients with arrhythmogenic right ventricular cardiomyopathy/dysplasia and no prior ventricular fibrillation (VF) or sustained ventricular tachycardia is an unsolved issue.

Methods and Results—

We studied 106 consecutive patients (62 men and 44 women; age, 35.6±18 years) with arrhythmogenic right ventricular cardiomyopathy/dysplasia who received an ICD based on 1 or more arrhythmic risk factors such as syncope, nonsustained ventricular tachycardia, familial sudden death, and inducibility at programmed ventricular stimulation. During follow-up of 58±35 months, 25 patients (24%) had appropriate ICD interventions and 17 (16%) had shocks for life-threatening VF or ventricular flutter. At 48 months, the actual survival rate was 100% compared with the VF/ventricular flutter–free survival rate of 77% (log-rank
P
=0.01). Syncope significantly predicted any appropriate ICD interventions (hazard ratio, 2.94; 95% confidence interval, 1.83 to 4.67;
P
=0.013) and shocks for VF/ventricular flutter (hazard ratio, 3.16; 95% confidence interval, 1.39 to 5.63;
P
=0.005). The positive predictive value of programmed ventricular stimulation was 35% for any appropriate ICD intervention and 20% for shocks for VF/ventricular flutter, with a negative predictive value of 70% and 74%. None of the 27 asymptomatic patients with isolated familial sudden death had appropriate ICD therapy. Twenty patients (19%) had inappropriate ICD interventions, and 18 (17%) had device-related complications.

Conclusions—
One fourth of patients with arrhythmogenic right ventricular cardiomyopathy/dysplasia and no prior sustained ventricular tachycardia or VF had appropriate ICD interventions. Syncope was an important predictor of life-saving ICD intervention and is an indication for ICD. Prophylactic ICD may not be indicated in asymptomatic patients because of their low arrhythmic risk regardless of familial sudden death and programmed ventricular stimulation findings. Programmed ventricular stimulation had a low predictive accuracy for ICD therapy.
Warming of Global Abyssal and Deep Southern Ocean Waters between the 1990s and 2000s: Contributions to Global Heat and Sea Level Rise Budgets*
Authors: Purkey Sarah G. , Johnson Gregory C. 
Published: September 2010

Abstract
Abyssal global and deep Southern Ocean temperature trends are quantified between the 1990s and 2000s to assess the role of recent warming of these regions in global heat and sea level budgets. The authors 1) compute warming rates with uncertainties along 28 full-depth, high-quality hydrographic sections that have been occupied two or more times between 1980 and 2010; 2) divide the global ocean into 32 basins, defined by the topography and climatological ocean bottom temperatures; and then 3) estimate temperature trends in the 24 sampled basins. The three southernmost basins show a strong statistically significant abyssal warming trend, with that warming signal weakening to the north in the central Pacific, western Atlantic, and eastern Indian Oceans. Eastern Atlantic and western Indian Ocean basins show statistically insignificant abyssal cooling trends. Excepting the Arctic Ocean and Nordic seas, the rate of abyssal (below 4000 m) global ocean heat content change in the 1990s and 2000s is equivalent to a heat flux of 0.027 (±0.009) W m−2 applied over the entire surface of the earth. Deep (1000–4000 m) warming south of the Subantarctic Front of the Antarctic Circumpolar Current adds 0.068 (±0.062) W m−2. The abyssal warming produces a 0.053 (±0.017) mm yr−1 increase in global average sea level and the deep warming south of the Subantarctic Front adds another 0.093 (±0.081) mm yr−1. Thus, warming in these regions, ventilated primarily by Antarctic Bottom Water, accounts for a statistically significant fraction of the present global energy and sea level budgets.
Assessment of the Effects of Tidal Mixing in the Kuril Straits on the Formation of the North Pacific Intermediate Water
Authors: Tanaka Yuki , Hibiya Toshiyuki , Niwa Yoshihiro 
Published: September 2010

Abstract
To assess accurately the effect of tidal mixing in the Kuril Straits on the formation of the North Pacific Intermediate Water (NPIW), the spatial distribution of diapycnal diffusivity recently obtained by the present authors is incorporated into an eddy-permitting OGCM. It is shown that the NPIW is successfully reproduced, although the diapycnal diffusivity averaged over the entire Kuril Straits is an order of magnitude less than has previously been assumed as a tuning parameter to reproduce the NPIW in low-resolution OGCMs. This strongly suggests that the effect of tidal mixing in the Kuril Straits on the formation of the NPIW is relatively minor and that the physical processes omitted by the low-resolution OGCMs, such as isopycnal mixing along the Kuroshio Extension region, are much more important. This suggestion gives warning of the danger that some misleading conclusions might be derived from OGCMs that employ diapycnal diffusivity just as a tuning parameter to reproduce the observed features.
The World Wide Lightning Location Network and Convective Activity in Tropical Cyclones
Authors: Abarca Sergio F. , Corbosiero Kristen L. , Vollaro David 
Published: September 2010

Abstract
Lightning flash density in tropical cyclones (TCs) is investigated to identify whether lightning flashes provide information on TC intensity and/or intensity change, to provide further insight into TC asymmetric convective structure induced by vertical shear and storm motion, and to assess how well the World Wide Lightning Location Network (WWLLN) is suited for the observation of TCs. The 24 Atlantic basin TCs that came within 400 km of the United States from 2004 to 2007 are studied. The National Lightning Detection Network is used to analyze flash density as a function of peak current and to evaluate the WWLLN. Flash density is shown to be smaller for hurricanes than for tropical depressions and storms, with this reduction being gradually more pronounced as flash peak current increases. The results suggest that flash density in the inner core is a parameter with potential for distinguishing intensifying versus nonintensifying TCs, particularly in the weaker storm stages where flash densities are largest.
Vertical wind shear produces a strong downshear left (right) asymmetry in the inner core (outer rainbands), whereas motion asymmetries are less clear. The unprecedented azimuthal resolution used in this study suggests that as shear strengthens, the azimuthal region of convection in the inner core is sharpened from a width of ∼130° to a width of ∼60°. The radial distribution of flash density is shown to exhibit a relatively narrow region of little activity (between 60 and 120 km from the eye), with increased activity in both regions closer to, and more distant from, the center (i.e., the eyewall and outer rainbands, respectively). Finally, it is shown that the WWLLN captures the convective activity in Atlantic basin TCs remarkably well, despite its low detection efficiency.
Predictability of North Atlantic Tropical Cyclone Activity on Intraseasonal Time Scales
Authors: Belanger James I. , Curry Judith A. , Webster Peter J. 
Published: September 2010

Abstract
Recent work suggests that there may exist skill in forecasting tropical cyclones (TC) using dynamically based ensemble products, such as those obtained from the ECMWF Monthly Forecast System (ECMFS). The ECMFS features an ensemble of 51 coupled ocean–atmosphere simulations integrated to 32 days once per week. Predicted levels of TC activity in the North Atlantic Ocean with these monthly ensemble forecasts is compared with the observed variability during the months of June–October during 2008 and 2009. Results indicate that the forecast system can capture large-scale regions that have a higher or lower risk of TC activity and that it has skill above climatology for the Gulf of Mexico and the “Main Development Region” on intraseasonal time scales. Regional forecast skill is traced to the model’s ability to capture the large-scale evolution of deep-layer vertical shear, the frequency of easterly waves, and the variance in 850-hPa relative vorticity. The predictability of TC activity, along with the forecast utility of the ECMFS, is shown to be sensitive to the phase and intensity of the Madden–Julian oscillation at the time of model initialization.
Heme oxygenase-1 plays a pro-life role in experimental brain stem death via nitric oxide synthase I/protein kinase G signaling at rostral ventrolateral medulla
Authors: Dai Kuang-Yu , Chan Samuel HH , Chang Alice YW 
Published: September 2010

AbstractBackgroundDespite its clinical importance, a dearth of information exists on the cellular and molecular mechanisms that underpin brain stem death. A suitable neural substrate for mechanistic delineation on brain stem death resides in the rostral ventrolateral medulla (RVLM) because it is the origin of a life-and-death signal that sequentially increases (pro-life) and decreases (pro-death) to reflect the advancing central cardiovascular regulatory dysfunction during the progression towards brain stem death in critically ill patients. The present study evaluated the hypothesis that heme oxygnase-1 (HO-1) may play a pro-life role as an interposing signal between hypoxia-inducible factor-1 (HIF-1) and nitric oxide synthase I (NOS I)/protein kinase G (PKG) cascade in RVLM, which sustains central cardiovascular regulatory functions during brain stem death.MethodsWe performed cardiovascular, pharmacological, biochemical and confocal microscopy experiments in conjunction with an experimental model of brain stem death that employed microinjection of the organophosphate insecticide mevinphos (Mev; 10 nmol) bilaterally into RVLM of adult male Sprague-Dawley rats.ResultsWestern blot analysis coupled with laser scanning confocal microscopy revealed that augmented HO-1 expression that was confined to the cytoplasm of RVLM neurons occurred preferentially during the pro-life phase of experimental brain stem death and was antagonized by immunoneutralization of HIF-1α or HIF-1β in RVLM. On the other hand, the cytoplasmic presence of HO-2 in RVLM neurons manifested insignificant changes during both phases. Furthermore, immunoneutralization of HO-1 or knockdown ofho-1gene in RVLM blunted the augmented life-and-death signals exhibited during the pro-life phase. Those pretreatments also blocked the upregulated pro-life NOS I/PKG signaling without affecting the pro-death NOS II/peroxynitrite cascade in RVLM.ConclusionsWe conclude that transcriptional upregulation of HO-1 on activation by HIF-1 in RVLM plays a preferential pro-life role by sustaining central cardiovascular regulatory functions during brain stem death via upregulation of NOS I/PKG signaling pathway. Our results further showed that the pro-dead NOS II/peroxynitrite cascade in RVLM is not included in this repertoire of cellular events.
Distinct α subunit variations of the hypothalamic GABAA receptor triplets (αβγ) are linked to hibernating state in hamsters
Authors: Alò Raffaella , Avolio Ennio , Di Vito Anna , Carelli Antonio , Facciolo Rosa Maria , Canonaco Marcello 
Published: September 2010

AbstractBackgroundThe structural arrangement of the γ-aminobutyric acid type A receptor (GABAAR) is known to be crucial for the maintenance of cerebral-dependent homeostatic mechanisms during the promotion of highly adaptive neurophysiological events of the permissive hibernating rodent, i.e the Syrian golden hamster. In this study,in vitroquantitative autoradiography andin situhybridization were assessed in major hypothalamic nuclei. Reverse Transcription Reaction-Polymerase chain reaction (RT-PCR) tests were performed for specific GABAAR receptor subunit gene primers synthases of non-hibernating (NHIB) and hibernating (HIB) hamsters. Attempts were made to identify the type of αβγ subunit combinations operating during the switching ON/OFF of neuronal activities in some hypothalamic nuclei of hibernators.ResultsBoth autoradiography and molecular analysis supplied distinct expression patterns of all α subunits considered as shown by a strong (p < 0.01) prevalence of α1ratio (over total α subunits considered in the present study) in the medial preoptic area (MPOA) and arcuate nucleus (Arc) of NHIBs with respect to HIBs. At the same time α2subunit levels proved to be typical of periventricular nucleus (Pe) and Arc of HIB, while strong α4expression levels were detected during awakening state in the key circadian hypothalamic station, i.e. the suprachiasmatic nucleus (Sch; 60%). Regarding the other two subunits (β and γ), elevated β3and γ3mRNAs levels mostly characterized MPOA of HIBs, while prevalently elevated expression concentrations of the same subunits were also typical of Sch, even though this time during the awakening state. In the case of Arc, notably elevated levels were obtained for β3and γ2during hibernating conditions.ConclusionWe conclude that different αβγ subunits are operating as major elements either at the onset of torpor or during induction of the arousal state in the Syrian golden hamster. The identification of a brain regional distribution pattern of distinct GABAAR subunit combinations may prove to be very useful for highlighting GABAergic mechanisms functioning at least during the different physiological states of hibernators and this may have interesting therapeutic bearings on neurological sleeping disorders.
Self-reported sexually transmitted infections and their correlates among men who have sex with men in Norway: an Internet-based cross-sectional survey
Authors: Jakopanec Irena , Schimmer Barbara , Grjibovski Andrej M , Klouman Elise , Aavitsland Preben 
Published: September 2010

Abstract

Background
The incidences of reportable sexually transmitted infections (STI) among men who have sex with men (MSM) have increased since the late 1990 s in Norway. The objectives of our study were to assess factors, associated with recent selected STI among MSM, living in Norway in order to guide prevention measures.

Methods
We conducted a cross-sectional Internet-based survey during 1-19 October 2007 among members of a MSM-oriented Norwegian website using an anonymous questionnaire on demographics, sexual behaviour, drug and alcohol use, and STI. The studied outcomes were gonorrhoea, syphilis, HIV or Chlamydia infection in the previous 12 months. Associations between self-reported selected STI and their correlates were analysed by multivariable Poisson regression. P value for trend (p-trend), adjusted prevalence ratios (PR) with 95% confidence intervals [] were calculated.

Results
Among 2430 eligible 16-74 years old respondents, 184 (8%) reported having had one of the following: syphilis (n = 17), gonorrhoea (n = 35), HIV (n = 42) or Chlamydia (n = 126) diagnosed in the past 12 months. Reporting Chlamydia was associated with non-western background (PR 2.8 [1.4-5.7]), number of lifetime male partners (p-trend < 0.001), unsafe sex under the influence of alcohol (PR 1.8 [1.1-2.9]) and with younger age (p-trend = 0.002). Reporting gonorrhoea was associated with unrevealed background (PR 5.9 [1.3-26.3]), having more than 50 lifetime male partners (PR 4.5 [1.3-15.6]) and more than 5 partners in the past 6 months (PR 3.1 [1.1-8.8]), while mid-range income was protective (PR 0.1 [0.0-0.6]). Reporting HIV was associated with residing in Oslo or Akershus county (PR 2.3 [1.2-4.6]), non-western background (PR 5.4 [1.9-15.3]), unrevealed income (PR 10.4 [1.5-71.4]), number of lifetime male partners (p-trend < 0.001) and being under the influence of selected drugs during sex in the past 12 months (PR 5.2 [2.7-11.4]). In addition, the frequency of feeling drunk was reversibly associated with HIV.

Conclusions
Our study demonstrates different associations of demographic and behavioural factors with different STI outcomes in the study population. Number of lifetime male partners was the most important potential predictor for Chlamydia and HIV. The STI prevention efforts among MSM should focus on Oslo and Akershus, promote safe sex practices and tackle sex-related drug and alcohol use.
Internal mammary lymph node recurrence: rare but characteristic metastasis site in breast cancer
Authors: Chen Lei , Gu Yajia , Leaw Shiangjiin , Wang Zhonghua , Wang Peihua , Hu Xichun , Chen Jiayi , Lu Jingsong , Shao Zhimin 
Published: September 2010

Abstract

Background
To assess the frequency of IMLN recurrence, its associated risk factors with disease-free interval (DFI) and its predicting factors on overall survival time.

Methods
133 cases of breast cancer IMLN recurrence were identified via the computerized CT reporting system between February 2003 and June 2008, during which chest CT for patients with breast cancer (n = 8867) were performed consecutively at Cancer Hospital, Fudan University, Shanghai, China. Patients' charts were retrieved and patients' characteristics, disease characteristics, and treatments after recurrence were collected for analysis. The frequency was 1.5% (133/8867).

Results
IMLN recurrence was presented as the first metastatic site in 121 (91%) patients while 88 (66.2%) had other concurrent metastases. Typical chest CT images included swelling of the IMLN at the ipsilateral side with local lump and sternal erosion located mostly between the second and third intercostal space. The median disease-free interval (DFI) of IMLN recurrence was 38 months. The independent factors that could delay the IMLN recurrence were small tumor size (HR 0.5 95%CI: 0.4 - 0.8; p = 0.002), and positive ER/PR disease (HR 0.6, 95% CI: 0.4 - 0.9; p = 0.006). The median survival time after IMLN recurrence was 42 months, with a 5-year survival rate of 30%. Univariate analysis showed four variables significantly influenced the survival time: DFI of IMLN recurrence (p = 0.001), no concurrent distant metastasis (p = 0.024), endocrine therapy for patients with positive ER/PR (p = 0.000), radiotherapy (p = 0.040). The independent factors that reduced the death risk were no concurrent distant metastases (HR: 0.7, 95% CI: 0.4 - 0.9; p = 0.031), endocrine therapy for patients with positive ER/PR status (HR: 0.2, 95% CI: 0.1 - 0.5; p = 0.001) and palliative radiotherapy (HR: 0.3, 95% CI: 0.1- 0.9; p = 0.026).

Conclusions
The risk of IMLN recurrence is low and there are certain characteristics features on CT images. ER/PR status is both a risk factor for DFI of IMLN recurrence and a prognostic factor for overall survival after IMLN recurrence. Patients with only IMLN recurrence and/or local lesion have a good prognosis.
Acetylcholinesterase Inhibitors (AChEI's) for the treatment of visual hallucinations in schizophrenia: A review of the literature
Authors: Patel Sachin S , Attard Azizah , Jacobsen Pamela , Shergill Sukhi 
Published: September 2010

Abstract

Background
Visual hallucinations occur in various neurological diseases, but are most prominent in Lewy body dementia, Parkinson's disease and schizophrenia. The lifetime prevalence of visual hallucinations in patients with schizophrenia is much more common than conventionally thought and ranges from 24% to 72%. Cortical acetylcholine (ACh) depletion has been associated with visual hallucinations; the level of depletion being related directly to the severity of the symptoms. Current understanding of neurobiological visual processing and research in diseases with reduced cholinergic function, suggests that AChEI's may prove beneficial in treating visual hallucinations. This offers the potential for targeted drug therapy of clinically symptomatic visual hallucinations in patients with schizophrenia using acetylcholinesterase inhibition.

Methods
A systematic review was carried out investigating the evidence for the effects of AChEI's in treating visual hallucinations in Schizophrenia.

Results
No evidence was found relating to the specific role of AChEI's in treating visual hallucinations in this patient group.

Discussion
Given the use of AChEI's in targeted, symptom specific treatment in other neuropsychiatric disorders, it is surprising to find no related literature in schizophrenia patients. The use of AChEI's in schizophrenia has investigated effects on cognition primarily with non cognitive effects measured more broadly.

Conclusions
We would suggest that more focused research into the effects of AChEI's on positive symptoms of schizophrenia, specifically visual hallucinations, is needed.