bluuebunny/crossref_metadata_2025_split huggingface dataset:
Implication of perturbed axoglial apparatus in early pediatric multiple sclerosis
Authors: Dhaunchak Ajit Singh , Becker Christopher , Schulman Howard , De Faria Omar , Rajasekharan Sathyanath , Banwell Brenda , Colman David R. , Bar‐Or Amit ,   on behalf of the Canadian Pediatric Demyelinating Disease Group
Published: December 2011

AbstractCerebrospinal fluid samples collected from children during initial presentation of central nervous system inflammation, who may or may not subsequently be diagnosed as having multiple sclerosis (MS), were subjected to large‐scale proteomics screening. Unexpectedly, major compact myelin membrane proteins typically implicated in MS were not detected. However, multiple molecules that localize to the node of Ranvier and the surrounding axoglial apparatus membrane were implicated, indicating perturbed axon–glial interactions in those children destined for diagnosis of MS. Ann Neurol 2012;
Enhancing the affinity of SEB‐binding peptides by repeating their sequence
Authors: Dudak Fahriye Ceyda , Kılıç Nesrin , Demir Kadir , Yaşar Fatih , Boyacı İsmail Hakkı 
Published: December 2011

AbstractThe utilization of peptide ligands in biosensors and bioassays is dependent on achieving high affinity of these peptides toward their targets. In a previous report, we identified 12‐mer peptides that could selectively bind to Staphylococcal enterotoxin B (SEB) using a phage‐display library. In this study, we explore for new modification approaches to enhance the affinity of two different SEB‐binding peptides. In order to identify the binding regions of selected peptides, the charged residues and the ones, critical for the structure of peptide, were replaced with alanine. However, a specific binding region could not be suggested as all mutant peptides have lost their affinities toward SEB completely. The modifications for the affinity enhancement were done by repeating the 12‐mer peptide sequences. A 10‐fold increase was observed in the binding affinity of one of the two‐repeated peptides, while this modification did not affect the affinity of the other tested peptide. The peptide, with enhanced affinity, was further modified as three repeats; however the affinity of the peptide decreased. The structural basis of the affinity difference between modified peptides was examined by molecular dynamics simulation. The results showed that the conformational differences hold the key for affinity of peptides modified by repeating the sequence. This high affinity peptide with increased affinity is a promising molecular recognition agent to be used in the detection of SEB to be utilized in biosensing systems. © 2011 Wiley Periodicals, Inc. Biopolymers (Pept Sci) 98: 145–154, 2012.
Cross‐case Methodology: Bringing Rigour to Community and Systems Change Research and Evaluation
Authors: Lee Kien S. , Chavis David M. 
Published: December 2011

ABSTRACTCross‐case study methodology is a more appropriate and still rigorous methodology for community and systems change research and evaluation. It supports learning about effective implementation, community capacity building, and resident engagement—all core elements of community and systems change efforts. It also communicates more effectively to non‐researchers and evaluators if, how, and why community and systems change occurred through the use of a narrative that combines qualitative and quantitative data to tell a story. The application of the cross‐case study methodology, adapted from Yin's cross‐case synthesis approach, requires five essential steps: developing a theory of change, establishing a measurement framework that reflects methodological and data source triangulation, developing a cross‐case study protocol and building a database, analysing and interpreting the findings, and communicating the results. This methodology was applied to the evaluation of the Safe Start Demonstration Project, a national community and systems change effort funded by the US Department of Justice, Office of Juvenile Justice and Delinquency Prevention. This methodology has all the attributes of scientific rigour. In this paper, we argue for a reconsideration of case study research by funders, policymakers, researchers, and evaluators and advance the cross‐case methodology as the emerging standard for community and systems change research and evaluation. Copyright © 2011 John Wiley & Sons, Ltd.
Responsive Vesicles from the Self‐Assembly of Crystalline‐Coil Polyferrocenylsilane‐block‐Poly(ethylene Oxide) Star‐Block Copolymers
Authors: Schacher Felix H. , Elbert Johannes , Patra Sanjib K. , Mohd Yusoff Siti F. , Winnik Mitchell A. , Manners Ian 
Published: December 2011

AbstractWe demonstrate the synthesis and characterization of star‐shaped crystalline‐coil block copolymers with four arms consisting of an inner block of poly(ethylene oxide) and an outer semicrystalline compartment of poly(ferrocenyldimethylsilane), [PEO50‐b‐PFDMS35]4. The materials were synthesized by transition‐metal‐catalyzed ring‐opening polymerization of dimethylsila[1]ferrocenophane in the presence of silane‐functionalized four‐arm PEO stars as macroinitiators and they exhibited a moderate polydispersity (PDI≅1.4). Self‐assembly in mixtures of THF and different alcohols as selective solvents for the PEO block resulted in the formation of semicrystalline vesicles (ethanol, 1‐butanol) or large, rather ill‐defined, spherical structures (methanol). Further, both the rate of addition of the selective co‐solvent and the overall solvent/non‐solvent ratio drastically affected the size and stability of the self‐assembled particles. We could also show that a photoacid generator, as a model for an active substance, can be encapsulated and the UV‐induced generation of HCl resulted in a straightforward degradation of the organometallic vesicles.
Staining of Fluid‐Catalytic‐Cracking Catalysts: Localising Brønsted Acidity within a Single Catalyst Particle
Authors: Buurmans Inge L. C. , Ruiz‐Martínez Javier , van Leeuwen Sanne L. , van der Beek David , Bergwerff Jaap A. , Knowles William V. , Vogt Eelco T. C. , Weckhuysen Bert M. 
Published: December 2011

AbstractA time‐resolved in situ micro‐spectroscopic approach has been used to investigate the Brønsted acidic properties of fluid‐catalytic‐cracking (FCC) catalysts at the single particle level by applying the acid‐catalysed styrene oligomerisation probe reaction. The reactivity of individual FCC components (zeolite, clay, alumina and silica) was monitored by UV/Vis micro‐spectroscopy and showed that only clay and zeolites (Y and ZSM‐5) contain Brønsted acid sites that are strong enough to catalyse the conversion of 4‐fluorostyrene into carbocationic species. By applying the same approach to complete FCC catalyst particles, it has been found that the fingerprint of the zeolitic UV/Vis spectra is clearly recognisable. This almost exclusive zeolitic activity is confirmed by the fact that hardly any reactivity is observed for FCC particles that contain no zeolite. Confocal fluorescence microscopy images of FCC catalyst particles reveal inhomogeneously distributed micron‐sized zeolite domains with a highly fluorescent signal upon reaction. By examining laboratory deactivated FCC catalyst particles in a statistical approach, a clear trend of decreasing fluorescence intensity, and thus Brønsted acidity, of the zeolite domains is observed with increasing severity of the deactivation method. By comparing the average fluorescence intensities obtained with two styrenes that differ in reactivity, it has been found that the Brønsted acid site strength within FCC catalyst particles containing ZSM‐5 is more uniform than within those containing zeolite Y, as confirmed with temperature‐programmed desorption of ammonia.
ChemInform Abstract: Germanium Selenophosphates: The Incommensurately Modulated 1∞ [Ge4‐xPxSe124‐] and the Molecular [Ge2P2Se14]6‐.
Authors: Morris Collin D. , Malliakas Christos D. , Kanatzidis Mercouri G. 
Published: December 2011

AbstractThe one‐dimensional metastable compound (III) crystallizes in the monoclinic space group P21/c with Z = 1 (single crystal XRD).
ChemInform Abstract: Facile Synthesis of Zero‐, One‐, and Two‐Dimensional Vanadyl Pyrophosphates.
Authors: Solis‐Ibarra Diego , Silvia Jared S. , Jancik Vojtech , Cummins Christopher C. 
Published: December 2011

AbstractThe structures of (III) and (VI) are determined by single crystal XRD.
ChemInform Abstract: Chiral Sulfoxide‐Olefin Ligands: Completely Switchable Stereoselectivity in Rhodium‐Catalyzed Asymmetric Conjugate Additions.
Authors: Chen Guihua , Gui Jiangyang , Li Liangchun , Liao Jian 
Published: December 2011

AbstractThe new catalyst system is also applicable to aliphatic boronic acid (IIf).
ChemInform Abstract: Indium‐Catalyzed Construction of Polycyclic Aromatic Hydrocarbon Skeletons via Dehydration.
Authors: Kuninobu Yoichiro , Tatsuzaki Tomohiro , Matsuki Takashi , Takai Kazuhiko 
Published: December 2011

AbstractA number of polycyclic aromatic hydrocarbons is available.
ChemInform Abstract: Gold‐Catalyzed Cyclization of Nonterminal Propargylic Amides to Substituted Alkylideneoxazolines and ‐oxazines.
Authors: Hashmi A. Stephen K. , Schuster Andreas M. , Schmuck Martin , Rominger Frank 
Published: December 2011

AbstractCyclization of nonterminal propargylic amides is achieved using a AuCl(IPr)—AgOTos catalytic system.
ChemInform Abstract: Development of PhSCF2CF2SiMe3 as a Tandem Anion and Radical Tetrafluoroethylene Equivalent: Preparation of Tetrafluoroethyl‐Substituted Alcohols and Tetrafluorotetrahydropyrans.
Authors: Chernykh Yana , Hlat‐Glembova Katarina , Klepetarova Blanka , Beier Petr 
Published: December 2011

AbstractTitle tetrafluoroethylene reagent contains an anionic and a radical CF2 side.
ChemInform Abstract: Efficient Palladium‐Catalyzed Suzuki—Miyaura Cross‐Coupling of Iodoethynes with Arylboronic Acids under Aerobic Conditions.
Authors: Tang Jian‐Sheng , Xie Ye‐Xiang , Wang Zhi‐Qiang , Li Jin‐Heng 
Published: December 2011

AbstractThe optimized conditions allow the coupling of various iodoethynes with arylboronic acids under mild aerobic conditions without the need for ligands.
ChemInform Abstract: Ir(I)‐Catalyzed Enantioselective Secondary sp3 C—H Bond Activation of 2‐(Alkylamino)pyridines with Alkenes.
Authors: Pan Shiguang , Endo Kohei , Shibata Takanori 
Published: December 2011

AbstractThe method renders possible a highly enantioselective activation of C—H bonds which are not located at an allylic or benzylic position.
ChemInform Abstract: N‐Heterocyclic Carbene‐Catalyzed Hydrosilylation of Styryl and Propargylic Alcohols with Dihydrosilanes.
Authors: Zhao Qiwu , Curran Dennis P. , Malacria Max , Fensterbank Louis , Goddard Jean‐Philippe , Lacote Emmanuel 
Published: December 2011

AbstractThe carbene derived from triazolium salt TRC catalyzes the title reactions to give the corresponding saturated alcohols or (E)‐alkenols, correspondingly, after quenching of the resulting siloxanes with Bu4NF.
ChemInform Abstract: Pd‐Catalyzed Cyanation of Benzyl Chlorides with Nontoxic K4[Fe(CN)6].
Authors: Ren Yunlai , Yan Mengjie , Zhao Shuang , Sun Yanpei , Wang Jianji , Yin Weiping , Liu Zhifei 
Published: December 2011

AbstractThe reaction allows the conversion of benzyl chlorides to benzyl cyanides.
ChemInform Abstract: Regioselective Approach to Multisubstituted Benzenes.
Authors: Seo Hana , Ohmori Ken , Suzuki Keisuke 
Published: December 2011

AbstractA facile chemo‐ and regioselective synthesis of various multisubstituted benzenes from the compound (I) is presented via nucleophilic aromatic substitution and ortho‐metalation reactions.
ChemInform Abstract: One‐Pot Synthesis of Diazine‐Bridged Bisindoles and Concise Synthesis of the Marine Alkaloid Hyrtinadine A.
Authors: Tasch Boris O. A. , Merkul Eugen , Mueller Thomas J. J. 
Published: December 2011

AbstractA one‐pot Masuda borylation—Suzuki arylation sequence is successfully applied to the synthesis of hetarylene‐bridged bisindole derivatives (III) and (VI).
ChemInform Abstract: The Asymmetric Friedel—Crafts Reaction of Indoles with Fluoroalkylated Nitroalkenes Catalyzed by Chiral Phosphoric Acid.
Authors: Lin Jin‐Hong , Xiao Ji‐Chang 
Published: December 2011

AbstractTitle reaction proceeds with excellent regioselectivity at the C(sp2) atom adjacent to the fluoroalkyl group.
ChemInform Abstract: Synthesis of Some New Chalcones, Pyrazolines and Acetyl Pyrazolines Derived from Piperonal and Halogenohydroxy Acetophenones as Antimicrobial Agents.
Authors: Karamunge Khushal G. , Sayyed Mudassar A. , Vibhute Archana Y. , Vibhute Yeshwant B. 
Published: December 2011

AbstractSome of the title compounds, especially derivatives having two halogen‐substituents, show better antimicrobial activity than the standard penicillin.
ChemInform Abstract: Intermolecular Twofold Carbopalladation/Cyclization Sequence to Access Chromans and Isochromans from Carbohydrates.
Authors: Leibeling Markus , Milde Bastian , Kratzert Daniel , Stalke Dietmar , Werz Daniel B. 
Published: December 2011

AbstractO‐Protected bromoglycals bearing a propargyl group either at the 1‐ or 3‐position react with terminal or internal alkynes under optimized conditions to give chromans and isochromans, correspondingly.
ChemInform Abstract: Structure of the Product of the Interaction of Methyl Anthranilate with N‐(4,6‐Dimethylpyrimidin‐2‐yl)cyanamide.
Authors: Shestakov A. S. , Bushmarinov I. S. , Sidorenko O. E. , Potapov A. Yu. , Shikhaliev Kh. S. , Antipin M. Yu. 
Published: December 2011

AbstractThe reaction of methyl anthranilate (I) with title compound (II) leads exclusively to quinazolinone (III) rather than its isomer (IV).
ChemInform Abstract: Novel Approach to the Synthesis of 6,7‐Dihydroquinazolino[3,2‐a][1,5]benzodiazepin‐13(15)‐ones.
Authors: Janciene R. 
Published: December 2011

AbstractCatalytic hydrogenation of 1‐(o‐nitrobenzoyl)tetrahydrobenzodiazepinones (III) results in a reductive cyclization furnishing previously unknown quinazolinobenzodiazepinones (IV).
ChemInform Abstract: Synthesis and Anticancer Activity of 13‐Membered Cyclic Enediynes.
Authors: Sharma Mukul , Joshi Mukesh C. , Kumar Vineet , Malhotra Sanjay V. , Rawat Diwan S. 
Published: December 2011

AbstractFifteen novel cyclic enediynes are prepared by using a simple and straightforward approach.
ChemInform Abstract: A New Solvent‐Free Reaction for the Preparation of Alkoxysilane from Cyclic Ethers, Alcohols, or Carbonyl Compounds.
Authors: Pehlivan Leyla , Metay Estelle , Boyron Olivier , Demonchaux Patrice , Mignani Gerard , Lemaire Marc 
Published: December 2011

AbstractThe Pd‐catalyzed ring opening—silylation of epoxides (I) and cyclic ethers, e.g. (VIII), with tetramethyldisiloxane (II) provides a novel access towards silyl‐protected alcohols.
ChemInform Abstract: Synthesis and Reactions of Some New Selenolo[2,3‐c]pyridazines.
Authors: Abdel‐Hafez S. H. , Abdel‐Monem M. I. , Mohamed M. G. , Abdelrazek F. M. , Metwally S. A. M. 
Published: December 2011

AbstractA new series of selenopyridazine and pyrimidoselenopyridazine derivatives are synthesized as possible biodegradable agrochemicals starting from selenolo[2,3‐c]pyridazines (I), (XI) or (XXII).
ChemInform Abstract: Cyclopropyl Methyl Bromide‐Mediated gem‐Diallylation: Total Synthesis of (.+‐.)‐α‐Cuparenone.
Authors: Shivakumar I. , Salunke Ganesh B. , Kumar Suneel 
Published: December 2011

Abstract(.+‐.)‐α‐cuparenone (IX) is prepared in 15% overall yield.
ChemInform Abstract: Premnalatifolin A, a Novel Dimeric Diterpene from Premna latifolia Roxb.
Authors: Suresh G. , Babu K. Suresh , Rao M. Suri Appa , Rao V. Rama Subba , Yadav P. Ashok , Nayak V. Lakshma , Ramakrishna Sistla 
Published: December 2011

AbstractThe title compound (I) exhibits significant anticancer activity against HT‐29 and MCF‐7 cell lines.
ChemInform Abstract: Synthesis and Evaluation of Quinazolin‐4‐ones as Hypoxia‐Inducible Factor‐1α Inhibitors.
Authors: Huang Wenwei , Huang Ruili , Attene‐Ramos Matias S. , Sakamuru Srilatha , Englund Erika E. , Inglese James , Austin Christopher P. , Xia Menghang 
Published: December 2011

AbstractThree areas of an initial quinazolinone‐based screening hit are modified for structure—activity relationship studies: the left part of the quinazolinone core, the piperazine region, and phenyl ring substitution.
ChemInform Abstract: Inhibition of Restriction Enzymes EcoRI, BamHI and HindIII by Phenethylphenylphthalimides Derived from Thalidomide.
Authors: Motoshima Kazunori , Ishikawa Minoru , Hashimoto Yuichi , Sugita Kazuyuki 
Published: December 2011

AbstractThe compounds (I) show potent EcoRI‐inhibitory activity (IC50 = 4.2 and 5.3 μm, respectively) and modest BamHI‐ and HindIII‐inhibitory activities.
ChemInform Abstract: 2‐Acyl‐tetrahydroisoquinoline‐3‐carboxylic Acids: Lead Compounds with Triple Actions, Peroxisome Proliferator‐Activated Receptor α/γ Agonist and Protein‐Tyrosine Phosphatase 1B Inhibitory Activities.
Authors: Otake Kazuya , Azukizawa Satoru , Takahashi Kenji , Fukui Masaki , Shibabayashi Michiko , Kamemoto Hikaru , Kasai Masayuki , Shirahase Hiroaki 
Published: December 2011

AbstractThe compound (I) is a bioavailable peroxisome proliferator‐activated receptor α/γ dual agonist with a ten‐fold weaker protein‐tyrosine phosphatase 1B (PTP‐1B) inhibitory activity than that of the PTP‐1B inhibitor ertiprotafib.
Energy from Plants and Microorganisms: Progress in Plant–Microbial Fuel Cells
Authors: Deng Huan , Chen Zheng , Zhao Feng 
Published: December 2011

AbstractPlant–microbial fuel cells (PMFCs) are newly emerging devices, in which electricity can be generated by microorganisms that use root exudates as fuel. This review presents the development of PMFCs, with a summary of their power generation, configurations, plant types, anode and cathode materials, biofilm communities, potential applications, and future directions.
A dynamic radio resource management scheme for the IEEE 802.16 band‐adaptive modulation and coding mode with proportional rate constraints
Authors: Sokar Mina A.A. , Elsayed Khaled M.F. 
Published: December 2011

ABSTRACTIn this paper, we consider the problem of downlink resource allocation in the IEEE 802.16 standard based on the orthogonal frequency‐division multiple access physical layer. The objective is to allocate the downlink frequency‐time slots and transmission power to different users such that the total throughput is maximized. The allocation is subject to constraints on the total transmission power and satisfying the quality of service requirements of different users expressed in terms of proportional rates. A three‐step heuristic scheme that incorporates a linear programming technique is proposed. The problem is modelled as an unbalanced transportation problem that is solved to obtain the users' slot assignment. The Vogel approximation method is used to efficiently solve the transportation problem with a slight degradation relative to the optimal solution. The Vogel approximation method gain is shown by replacing it in the three‐step heuristic by simple round‐robin or greedy slot assignment. In terms of total throughput and fairness, it is shown that the proposed scheme is a good compromise between the greedy‐oriented schemes, which aspire to maximize the total system throughput but sacrificing fairness, and a proportional rate constraints scheme introduced in the literature that achieved short‐term fairness but penalizes the total throughput. The study also shows that the proposed scheme consumes a fraction of the time needed by the proportional rate constraints scheme. Copyright © 2011 John Wiley & Sons, Ltd.
Rapamycin impairs UV induction of mutant‐p53 overexpressing cell clusters without affecting tumor onset
Authors: Voskamp P. , Bodmann C.A. , Rebel H.G. , Koehl G.E. , Tensen C.P. , Bouwes Bavinck J.N. , El Ghalbzouri A. , Van Kranen H.J. , Willemze R. , Geissler E.K. , De Gruijl F.R. 
Published: December 2011

AbstractBecause of its antitumor effect, the immunosuppressant rapamycin holds great promise for organ transplant recipients in that it may lower their cancer risk. In a mouse model, we showed previously that rapamycin inhibits the outgrowth of primary skin carcinomas induced by UV radiation. However, the tumors that did grow out showed an altered p53 mutation spectrum. Here, we investigated whether this shift in p53 mutations already occurred in the smallest tumors, which were not affected in onset. We found that rapamycin did not alter the mutational spectrum in small tumors and in preceding microscopic clusters of cells expressing mutant‐p53. However, rapamycin did reduce the number of these cell clusters. As this reduction did not affect tumor onset, we subsequently investigated whether rapamycin merely suppressed expression of mutated p53. This was not the case, as we could demonstrate that switching from a diet with rapamycin to one without, or vice versa, did not affect the number of existing mutant‐p53 expressing cell clusters. Hence, rapamycin actually reduced the formation of mutant‐p53 cell clusters. In wild‐type and p53‐mutant mice, we could not measure a significant enhancement of UV‐induced apoptosis, but we did observe clear enhancement in human skin equivalents. This was associated with a clear suppression of HIF1α accumulation. Thus, we conclude that rapamycin reduces the formation of mutant‐p53‐expressing cell clusters without affecting tumor onset, suggesting that tumors grow out of a minor subset of cell clusters, the formation of which is not affected by rapamycin.
The monocarboxylate transporter family—Role and regulation
Authors: Halestrap Andrew P. , Wilson Marieangela C. 
Published: December 2011

AbstractMonocarboxylate transporter (MCT) isoforms 1–4 catalyze the proton‐linked transport of monocarboxylates such as L‐lactate across the plasma membrane, whereas MCT8 and MCT10 are thyroid hormone and aromatic amino acid transporters, respectively. The importance of MCTs is becoming increasingly evident as their extensive physiological and pathological roles are revealed. MCTs 1–4 play essential metabolic roles in most tissues with their distinct properties, expression profile, and subcellular localization matching the particular metabolic needs of a tissue. Important metabolic roles include energy metabolism in the brain, skeletal muscle, heart, tumor cells, and T‐lymphocyte activation, gluconeogenesis in the liver and kidney, spermatogenesis, bowel metabolism of short‐chain fatty acids, and drug transport. MCT8 is essential for thyroid hormone transport across the blood–brain barrier. Genetic perturbation of MCT function may be involved in disease states such as pancreatic β‐cell malfunction (inappropriate MCT1 expression), chronic fatigue syndromes (impairment of muscle MCT function), and psychomotor retardation (MCT8 mutation). MCT expression can be regulated at both the transcriptional and post‐transcriptional levels. Of particular importance is the upregulation of muscle MCT1 expression in response to training and MCT4 expression in response to hypoxia. The latter is mediated by hypoxia inducible factor 1α and often observed in tumor cells that rely almost entirely on glycolysis for their energy provision. The recent discovery of potent and specific MCT1 inhibitors that prevent proliferation of T‐lymphocytes confirms that MCTs may be promising pharmacological targets including for cancer chemotherapy. © 2011 IUBMB IUBMB Life, 2011.