bluuebunny/crossref_metadata_2025_split huggingface dataset:
Three-dimensional cardiac magnetic resonance allows the identification of slow-conducting anatomical isthmuses in tetralogy of Fallot
Authors: Kimura Yoshitaka , Wallet Justin , Bouyer Benjamin , Jongbloed Monique R M , Bertels Robin , Hazekamp Mark G , Thambo Jean-Benoit , Iriart Xavier , Cochet Hubert , Sacher Frederic , Lamb Hildo J , Blom Nico A , Zeppenfeld Katja 
Published: May 2024

Abstract

Background and Aims
Patients with repaired tetralogy of Fallot remain at risk of life-threatening ventricular tachycardia related to slow-conducting anatomical isthmuses (SCAIs). Preventive ablation of SCAI identified by invasive electroanatomical mapping is increasingly performed. This study aimed to non-invasively identify SCAI using 3D late gadolinium enhancement cardiac magnetic resonance (3D-LGE-CMR).

Methods
Consecutive tetralogy of Fallot patients who underwent right ventricular electroanatomical mapping (RV-EAM) and 3D-LGE-CMR were included. High signal intensity threshold for abnormal myocardium was determined based on direct comparison of bipolar voltages and signal intensity by co-registration of RV-EAM with 3D-LGE-CMR. The diagnostic performance of 3D-LGE-CMR to non-invasively identify SCAI was determined, validated in a second cohort, and compared with the discriminative ability of proposed risk scores.

Results
The derivation cohort consisted of 48 (34 ± 16 years) and the validation cohort of 53 patients (36 ± 18 years). In the derivation cohort, 78 of 107 anatomical isthmuses (AIs) identified by EAM were normal-conducting AI, 22 were SCAI, and 7 blocked AI. High signal intensity threshold was 42% of the maximal signal intensity. The sensitivity and specificity of 3D-LGE-CMR for identifying SCAI or blocked AI were 100% and 90%, respectively. In the validation cohort, 85 of 124 AIs were normal-conducting AI, 36 were SCAI, and 3 blocked AI. The sensitivity and specificity of 3D-LGE-CMR were 95% and 91%, respectively. All risk scores showed an at best modest performance to identify SCAI (area under the curve ≤ .68).

Conclusions
3D late gadolinium enhancement cardiac magnetic resonance can identify SCAI with excellent accuracy and may refine non-invasive risk stratification and patient selection for invasive EAM in tetralogy of Fallot.
Differences in colorectal cancer awareness between screening eligible vs. ineligible Palestinians: a national cross-sectional study
Authors: Elshami Mohamedraed , Albandak Maram , Alser Mohammed , Al-Slaibi Ibrahim , Ayyad Mohammed , Dwikat Mohammad F , Naji Shoruq A , Mohamad Balqees M , Isleem Wejdan S , Shurrab Adela , Yaghi Bashar , Ayyash Qabaja Yahya , Hamdan Fatma K , Sweity Raneen R , Jneed Remah T , Assaf Khayria A , Hmaid Mohammed M , Awwad Iyas I , Alhabil Belal K , Alarda Marah N , Alsattari Amani S , Aboyousef Moumen S , Aljbour Omar A , AlSharif Rinad , Giacaman Christy T , Alnaga Ali Y , Abu Nemer Ranin M , Almadhoun Nada M , Skaik Sondos M , Albarqi Shurouq I , Abu-El-Noor Nasser , Bottcher Bettina 
Published: May 2024

Abstract

Background
This study aimed to compare colorectal cancer (CRC) awareness between screening-eligible and ineligible individuals in Palestine.

Methods
Convenience sampling was utilized to recruit Palestinian adults from diverse settings, including hospitals, primary healthcare centers and public spaces across 11 governorates. The evaluation of CRC awareness in terms of signs/symptoms, risk factors and causation myths was conducted using Arabic-translated, modified versions of the validated instruments, the Bowel Cancer Awareness Measure and the Cancer Awareness Measure-Mythical Causes Scale.

Results
The final analysis included 2698 participants, with 2158 (80.9%) eligible for CRC screening and 540 (19.1%) ineligible for it. The most recognized CRC sign/symptom was ‘lump in the abdomen’ in both screening-eligible (n = 386, 71.5%) and ineligible (n = 1582, 73.3%) groups. ‘Lack of physical activity’ was the most recognized risk factor in both groups (eligible: n = 451, 83.5%; ineligible: n = 1766, 81.8%). The most reported causation myth in both groups was ‘having a physical trauma’ (eligible: n = 340, 63.0%; ineligible: n = 1353, 62.7%). In the screening-eligible group, only 210 participants (38.9%) demonstrated high awareness of CRC signs/symptoms, 213 participants (39.4%) showed high awareness of CRC risk factors and only 46 participants (8.5%) displayed high awareness of CRC causation myths. There were no significant associations between being eligible for screening colonoscopy and the awareness levels of CRC signs/symptoms, risk factors and causation myths.

Conclusion
Overall, awareness levels of CRC signs/symptoms, risk factors and causation myths were notably low among screening-eligible participants. There were no differences in awareness levels between individuals eligible for colonoscopy and those who were not.
Ethnic Density as a Key Factor to Narrow Health Disparities: A Case of American Indians and Alaska Natives
Authors: Kim Yong-Mi , Noyori-Corbett Chie 
Published: May 2024

Abstract
Out of all the racial groups in the United States, people who identify as American Indian and Alaska Native (AI/AN) have disproportionately worse health as a result of living in poverty. The preponderance of research connects poor health with a socioeconomic perspective, which might create prejudice against AI/AN. As already known, AI/AN’s high rates of obesity, diabetes, and stroke in comparison with that of other ethnic groups are mainly derived from their impoverished economic conditions that have forced them to consume the food distributed by the U.S. government. When minority health is discussed generally, the ethnic density perspective explains a minority population’s positive health despite low socioeconomic status. This perspective helps researchers and practitioners understand the connections of psychological and social factors with physical health and demonstrates positive health effects on minority groups. Despite the high correlation between ethnic density and health having been validated, little to no research has explored AI/AN’s health from this perspective. Using 13,064 electronic health records, this research tests the relationship between AI/AN density and health outcomes. This article introduces an innovative analytical strategy (i.e., a data mining technique), which is ideal for discovering frequently appearing health outcomes in a group. The finding reveals positive relationships between health outcomes and AI/AN density.
From Metrics to Experiences: Investigating How Sport Data Shapes the Social Context, Self-Determination and Motivation of Athletes
Authors: Postma Dees , Reidsma Dennis , van Delden Robby , Karahanoğlu Armağan 
Published: May 2024

Abstract
In this paper, we use self-determination theory and its related mini-theories to investigate the influence of sport data on sports experience and motivation in sports. First, we reflect on the use of technology in sports and show how sport data thwarts and promotes motivation in sports. Second, we argue that human–computer interaction (HCI) has been too narrowly focused on the ‘performance’ aspect of sport data. We argue for a more liberal take on sport data, showing that it also relates to motivation in sports through basic human needs. By bridging SportsHCI studies with the insights we gain from self-determination theory, we uncover the interwoven relations between the objective measures that sports technology provides and their motivational aspects for athletes. Our paper ends with five emerging points for attention for SportsHCI that we think can pave the way towards a more holistic approach to considering sport data for motivation in sports.
Time is running out. No excuses to delay implementation of antimicrobial stewardship programmes: impact, sustainability, resilience and efficiency through an interrupted time series analysis (2017–2022)
Authors: Del Fabro Giovanni , Venturini Sergio , Avolio Manuela , Basaglia Giancarlo , Callegari Astrid , Bramuzzo Igor , Basso Barbara , Zanusso Chiara , Rizzo Anna , Tonutti Giuseppe , Chittaro Michele , Fiappo Eva , Tonizzo Maurizio , Crapis Massimo 
Published: May 2024

Abstract

Introduction
The WHO declared antimicrobial resistance (AMR) a significant concern in 2014, sparking initiatives to ensure responsible antibiotic use. In human medicine, Antimicrobial Stewardship Programmes (ASPs) in hospitals play a pivotal role in combating AMR. Although evidence supports the effectiveness of ASPs in optimizing antimicrobial use, often the lack of resources becomes an excuse to limit their dissemination and use. This paper provides a comprehensive report on a 6-year analysis of an ASP implemented in a healthcare region in north-east Italy.

Methods
A retrospective data collection was conducted to assess the programme's impact on antibiotic consumption expressed as DDDs/100 patient-days, its sustainability over time, resilience during the COVID-19 pandemic and the efficiency of the ASP (relationship between workload and human resources).

Results
A substantial overall reduction in antibiotic consumption (−14%), particularly in fluoroquinolones (−64%) and carbapenems (−68%), was demonstrated, showcasing the programme's impact. Sustainability was confirmed through enduring trends in antibiotic consumption and ecological analysis over time. The ASP demonstrates resilience by maintaining positive trends even amid the challenging COVID-19 pandemic. Efficiency was underscored by an increase in on-site consultations despite consistent human resources until 2021.

Conclusions
This study offers insights into the prolonged success of a resource-efficient ASP, emphasizing the crucial role of long-term commitment in fostering responsible antibiotic use in the context of global health challenges such as AMR.
Effectiveness of a tissue conditioner containing antifungals in a rat model of denture stomatitis
Authors: Moraes Gustavo Simão , Albach Thaís , Sugio Carolina Yoshi Campos , Cachoeira Victoria Schlumberger , Kiratcz Falyne , Tozetto Nathaly Mayer , Pedroso Thaynara Aparecida Alves , Campagnoli Eduardo Bauml , Claudino Marcela , dos Santos Fabio André , Neppelenbroek Karin Hermana , Urban Vanessa Migliorini 
Published: May 2024

Abstract

Aim
This study investigated the effectiveness of a drug-modified tissue conditioner in an animal model of denture stomatitis.

Methods and Results
Wistar rats wore a Candida albicans-contaminated palatal device for 4 days. Next, nystatin (Nys) or chlorhexidine (Chx) were added to a tissue conditioner in their raw or β-cyclodextrin-complexed (βCD) forms at their minimum inhibitory concentrations. As controls, one group was not subjected to any procedure (NC), one group used sterile devices, one group had denture stomatitis but was not treated (DS), and another had the devices relined with the tissue conditioner without the addition of any drug (Soft). After 4 days of treatment, treatment effectiveness was assessed visually, histologically, and through CFU count, and myeloperoxidase (MPO) and N-acetylglucosaminidase (NAG) assays. Rats from the Soft, Nys, Nys:βCD, and Chx groups presented a significant decrease in the microbial load compared with the untreated group. Treatment groups showed lower MPO and NAG activity compared to the non-treated group.

Conclusions
The addition of antifungals to a soft tissue conditioner can be a promising approach for denture stomatitis treatment.
Identification of cellular retinoic acid binding protein 2 (CRABP2) as downstream target of nuclear factor I/X (NFIX): implications for skeletal dysplasia syndromes
Authors: Kooblall Kreepa G , Stevenson Mark , Heilig Raphael , Stewart Michelle , Wright Benjamin , Lockstone Helen , Buck David , Fischer Roman , Wells Sara , Lines Kate E , Teboul Lydia , Hennekam Raoul C , Thakker Rajesh V 
Published: May 2024

Abstract
Nuclear factor I/X (NFIX) mutations are associated with 2 skeletal dysplasias, Marshall-Smith (MSS) and Malan (MAL) syndromes. NFIX encodes a transcription factor that regulates expression of genes, including Bobby sox (BBX) and glial fibrillary acidic protein (GFAP) in neural progenitor cells and astrocytes, respectively. To elucidate the role of NFIX mutations in MSS, we studied their effects in fibroblast cell lines obtained from 5 MSS unrelated patients and 3 unaffected individuals. The 5 MSS NFIX frameshift mutations in exons 6-8 comprised 3 deletions (c.819-732_1079-948del, c.819-471_1079-687del, c.819-592_1079-808del), an insertion (c.1037_1038insT), and a duplication (c.1090dupG). Quantitative reverse transcription polymerase chain reaction (qRT-PCR) and western blot analyses using MSS and unrelated control fibroblasts and in vitro expression studies in monkey kidney fibroblast (COS-7) cells showed that frameshift mutations in NFIX exons 6-8 generated mutant transcripts that were not cleared by nonsense-mediated-decay mechanisms and encoded truncated NFIX proteins. Moreover, BBX or GFAP expression was unaffected in the majority of MSS fibroblasts. To identify novel NFIX downstream target genes, RNA sequencing and proteomics analyses were performed on mouse embryonic fibroblast (MEF) cells derived from control Nfix+/+, Nfix+/Del2, Nfix+/Del24, NfixDel24/Del24, Nfix+/Del140, and NfixDel140/Del140 mice, compared with NfixDel2/Del2 mice which had developmental, skeletal, and neural abnormalities. This identified 191 transcripts and 815 proteins misregulated in NfixDel2/Del2 MEFs with ≥2-fold-change (P &lt;0 .05). Validation studies using qRT-PCR and western blot analyses confirmed that 2 genes, cellular retinoic acid binding protein 2 (Crabp2) and vascular cell adhesion molecule 1 (Vcam1), were misregulated at the RNA and protein levels in NfixDel2/Del2 MEFs, and that CRABP2 and VCAM1 expressions were altered in 60%–100% of MSS fibroblast cells. Furthermore, in vitro luciferase reporter assays confirmed that NFIX directly regulates CRABP2 promoter activity. Thus, these altered genes and pathways may represent possible targets for drugs as potential treatments and therapies for MSS.
Practical guidance for managing patients with moderate-to-severe ulcerative colitis using small molecule therapies
Authors: Jairath Vipul , Afif Waqqas , Bressler Brian , Pope Janet E , Selchen Daniel , Targownik Laura E , Panaccione Remo 
Published: May 2024

Abstract
Ulcerative colitis (UC) is a severe and debilitating illness that affects the quality of life and physical health of many Canadians. Given the dynamic and progressive nature of the disease, advanced therapies are required to support its long-term management. The emergence of small molecule therapies offers novel treatment options that target mechanisms central to the immunopathology of UC. Sphingosine-1-phosphate (S1P) receptor modulators and Janus-activated kinase inhibitors are 2 classes of therapies that target unique pathways to attenuate inflammation and modulate the immune response characteristic of UC. This review aims to provide practical guidance on how these therapeutic options can best be used to optimize treatment management and highlight the emerging role of small molecule therapies as a treatment strategy for UC.
The Science of Creating Brand Associations: A Continuous Trinity Model Linking Brand Associations to Learning Processes
Authors: du Plessis Christilene , D’Hooge Serena , Sweldens Steven 
Published: May 2024

Abstract
The continuous trinity model (CTM) of brand associations integrates 50 years of consumer learning research with recent conceptualizations of consciousness. Three types of brand associations are proposed at the representational level (expectations, meaning, and affect), corresponding to three types of learning at the process level (predictive learning, referential learning, and direct affect transfer). A core proposition derived from research on automaticity holds that the operating conditions of the learning processes vary on a continuum from mostly System 2 for predictive learning to mostly System 1 for direct affect transfer, with referential learning as a mix of the two. The CTM aims to bring clarity and structure to a complex literature by highlighting the web of interrelations between operating principles (“what” brand associations are learned), operating processes (“how” brand associations are learned), and operating conditions (“when” brand associations are learned). For consumer and learning researchers, the CTM outlines an agenda for future research and guidelines to improve conceptual and methodological clarity. For brand managers, the CTM provides tactical recommendations (a “toolkit”) for structuring advertising campaigns to create desired brand associations and strategic recommendations for managing brand partnerships. For policymakers, the CTM offers guidance on types of advertisements requiring closer scrutiny.
People, Peace, Prosperity, and the Planet: A Journey toward Sustainable Development in Consumer Research
Authors: Mende Martin , Borah Abhishek , Scott Maura L , Bolton Lisa E , Lee Leonard 
Published: May 2024

Abstract
With its 2030 Agenda for Sustainable Development, the United Nations (UN) developed 17 Sustainable Development Goals (SDGs) as a “blueprint for peace and prosperity for people and the planet.” This initiative raises the question: how has the Journal of Consumer Research (JCR) shed light on the SDGs? This research analyzes 50 years of consumer research through the lens of the SDG and makes four contributions. First, the authors provide a content analysis of articles in JCR and how it relates to the SDGs over time; they also analyze the Journal of Consumer Psychology (JCP) and Journal of Public Policy & Marketing (JPP&M) with regard to the SDGs. Second, this research reveals where JCR has made progress and achieved impact (via Altmetric) but also identifies gaps in the literature. Thus, the analyses shed light on what research in JCR, JCP, and JPP&M understands (and does not understand) about consumer behavior and points the way to future SDG-oriented research. Finally, based on insights from interviews with thought leaders, sociology of science, UN data dashboards, and an exploratory survey in three countries (the U.S., France, and Singapore), the authors provide recommendations on how the field can (better) incorporate the SDGs in research, teaching, and service.
Benchmarking Scholarship in Consumer Research: The p-Index of Thought Leadership
Authors: Pham Michel Tuan , Wu Alisa Yinghao , Wang Danqi 
Published: May 2024

Abstract
The assessment of consumer scholarship must move beyond a mere counting of the number of “A”s on a researcher’s CV to include at least some measure of impact. To facilitate a broader assessment of scholarship in consumer research, we provide detailed statistics on the productivity and citation impact of the field’s 340 main gatekeepers: the editors, associate editors, and editorial board members of the Journal of Consumer Research and the Journal of Consumer Psychology. In addition, we introduce a new metric, called the p-index, which can be interpreted as an indicator of a researcher’s propensity for thought leadership. Using this metric, we show that productivity and thought leadership do not necessarily go hand in hand in consumer research and that a combination of the two is a good predictor of the level of esteem that consumer scholars enjoy among their peers and of the receipt of major career awards. Our analyses provide greater transparency into how productivity, citation impact, and propensity for thought leadership are currently distributed among prominent consumer scholars. Furthermore, the detailed descriptive statistics reported can serve as useful benchmarks against which other consumer researchers’ records may be meaningfully compared.
Impact of copper and zinc oral chronic exposure on Carniolan honey bee survival and feeding preference
Authors: Glavan Gordana , Benko Grega , Božič Janko 
Published: May 2024

Abstract
Honey bees are important plant pollinators and honey producers. Contamination of the environment with metals can lead to a decline in honey bee populations. Copper (Cu) and zinc (Zn) salts are commonly used as fungicides and foliar fertilizers. In this study, we investigated the effects of 10-day chronic oral exposure to different concentrations of Cu (CuSO4) and Zn (ZnCl2) on survival and feeding rates of Carniolan honey bees in laboratory conditions. We found that mortality in honey bee workers increased in a concentration-dependent manner and that Cu (lethal concentration [LC50] = 66 mg/l) was more toxic than Zn (LC50 = 144 mg/l). There was no difference in the feeding rate of Cu-treated bees for the different concentrations tested, but the feeding rate decreased with the increase in Zn concentration. To determine feeding preference or avoidance for Cu and Zn, we conducted 2-choice 24-h feeding experiments. We demonstrated that honey bees preferred Zn-containing solutions compared to the control diet. A two-choice experiment with Cu showed a tendency for honey bees to be deterred by Cu at high concentrations; however, it was not statistically significant. In summary, our results suggest that honey bee workers may suffer adverse effects when exposed to ecologically relevant concentrations of Cu and Zn.
Modeling of host PDZ-dependent interactions with SARS-CoV-2 envelope protein and changes in PDZ protein expression in macrophages and dendritic cells
Authors: Rosas-García Jorge , Padilla-Zúñiga Alberta Jaqueline , Ávila-Flores Antonia , Gutiérrez-González Luis Horacio , Mérida Isabel , Santos-Mendoza Teresa 
Published: May 2024

Abstract
PDZ (PSD-95 [postsynaptic density protein 95]/Dlg [Discs large]/ZO-1 [zonula occludens-1]) domain–containing proteins constitute a large family of scaffolds involved in a wide range of cellular tasks and are mainly studied in polarity functions. Diverse host PDZ proteins can be targeted by viral pathogens that express proteins containing PDZ-binding motifs (PDZbms). Previously, we have identified host PDZ-based interactions with the SARS-CoV-2 E protein (2E) in human monocytes. Here, we deepen the study of these interactions by docking and molecular dynamics analyses to identify the most favorable PDZ-PDZbm interaction of 7 host PDZ proteins with the PDZbm of 2E. In addition, we analyzed changes in the expression of 3 of the PDZ proteins identified as 2E interactors in monocytes (syntenin, ZO-2, and interleukin-16), in human monocyte-derived macrophages and in dendritic cells upon stimulation. Our results suggest that these PDZ proteins may have important functions in professional antigen-presenting cells, and their targeting by the PDZbm of 2E, a central virulence determinant of SARS-CoV-2, supports the hypothesis that such PDZ-dependent interaction in immune cells may constitute a viral evasion mechanism. An inhibitor design based on the PDZbm of 2E in the development of drugs against a variety of diseases is discussed.