bluuebunny/crossref_metadata_2025_split huggingface dataset:
Nanovesicles as Potential Carriers for Delivery of Antiviral Drugs: A Comprehensive
Review
Authors: Bindhani Sabitri , Nayak Amit Kumar 
Published: June 2024

Abstract::
Different nanocarriers-based strategies are now extensively being used as an important
strategy for improving drug efficacy and responsiveness, reducing toxicity issues related to drugs
and harmful side effects, and overcoming the numerous significant difficulties related to absorption
and bioavailability. Amongst different nanocarriers, nanovesicles are excellent and versatile
systems for effectively delivering biomolecules, drugs, and targeted ligand distribution and location.
Nanovesicles are nanosized self-assembling spherical capsules with an aqueous core and
one/more lipid(s) layers. Several synthetic nanovesicles have been developed and investigated for
their prospective uses in delivering drugs, proteins, peptides, nutrients, etc. Important procedures
for nanovesicle manufacturing are thin-film hydration, unshaken method, ethanol injection, ether
injection, proliposomes, freeze-drying, hot method, cold method, reverse-phase evaporation, and
ultrasonication. Liposomes, liposomes, ethosomes, exosomes, and transferosomes (elastic vesicles)
are the nonvesicular candidates extensively investigated to deliver antiviral drugs. This review
article comprehensively reviews different nanovesicles, their compositions, manufacturing,
and applications as potential carriers for effectively delivering different antiviral drugs to treat viral
diseases.
Sexual Dysfunction in Iranian Women with Endometriosis: A Cross-sectional Study
Authors: Moghadam Zahra Behboodi , Namazi Masoumeh , Kamali Maede 
Published: June 2024

Objectives:
Endometriosis is a chronic disease that affects about 5-15% of women of
reproductive age. Considering the extensive impact of this disease on women's sexual function, the
present study was conducted to determine the prevalence of sexual dysfunction in Iranian women
with endometriosis and the factors associated with it.

Methods:
This cross-sectional study was performed on 300 women (150 women with endometriosis and 150 healthy women) at Imam Khomeini Hospital in Tehran city, Iran, from April to December 2022. Data collection was done using a paper form. Data collection tools included a
demographic information questionnaire, the Female Sexual Function Index (FSFI) questionnaire,
and the Depression, Anxiety, and Stress Scale (DASS-21) questionnaire. The data were analyzed
using SPSS software version 24, employing descriptive and analytical statistics.

Results:
The prevalence of sexual dysfunction was 65.34% in women with endometriosis and 46%
in healthy individuals. There was a significant relationship between age, menstrual status, stress,
anxiety, and depression with sexual dysfunction in women with endometriosis (p < 0.05). Additionally, individuals with endometriosis were more susceptible to stress, anxiety, and depression
compared to healthy individuals (p < 0.05).

Conclusion:
Considering the high prevalence of sexual dysfunction in Iranian women with
endometriosis, addressing sexual issues in individuals with endometriosis should be a consideration
for healthcare providers, and systematic programs should be implemented to improve their sexual
health.
The Effectiveness of Educational Intervention for Awareness of Premenstrual Syndrome on Marital Satisfaction and Marital Adjustment
Authors: Firozi Fatteme , Khalajinia Zohre , Rahimi Hanieh , Hasheminejad Soosan Sadat 
Published: June 2024

Background:
Premenstrual Syndrome (PMS) is one of the most common psychosomatic
disorders in women of reproductive age, affecting their daily activities. This syndrome also has a
negative impact on marital satisfaction and marital adjustment. Therefore, a study was conducted in
2022 with the aim of investigating the effect of an educational intervention in women with premenstrual
syndrome and their spouses on marital satisfaction and marital adjustment in comprehensive
health centers in Qom City.

Method:
This interventional study was conducted on two groups in 2022, including 41 participants
in the intervention group and 39 participants in the control group who were referred to healthcare
centers of Qom University of Medical Sciences. Sampling was conductedthrough multi-stage sampling.
Data collection tools included a Premenstrual Symptoms Screening Tool, the Index
of Marital Satisfaction (IMS), and the Spanier Dyadic Adjustment Scale. The individuals in the intervention
group received educational sessions on PMS over four sessions, each lasting two hours.
The collected data were analyzed using SPSS version 16, utilizing t-tests and Chi-squared tests. A
significant level of 0.05 was considered.

Results:
A statistically significant difference was observed in the mean score of the Marital Satisfaction
Questionnaire between the intervention and control groups after the intervention (p = 0.01).
Additionally, there were significant differences in the mean scores of the Spanier Dyadic
Adjustment Scale's total score (p = 0.019), correlation dimension (p = 0.001), and affection expression
dimension (p = 0.044) between the two groups after the intervention.

Conclusion:
Educating couples about Premenstrual sSyndrome (PMS) can lead to increased marital
satisfaction and marital adjustment. It is recommended that structured educational programs on
PMS and support for affected women's spouses be implemented in healthcare centers.
Perceived Stress and Related Factors in Iranian High-Risk Pregnant Mothers: A Cross-Sectional Study
Authors: Aliabadi Sahar , Jafari Mobina , Kazemi Farideh , Masoumi Seyedeh Zahra , Refaei Mansoureh 
Published: June 2024

Background:
Pregnancy with high-risk factors can lead to adverse emotional experiences
for the expectant mother.

Objective:
This study aimed to explore perceived stress and contributing factors among expectant
mothers with high-risk pregnancies.

Methods:
In 2022, a descriptive-analytical study was conducted on 150 high-risk pregnant mothers
in comprehensive health centers in Hamadan, Iran. Convenience sampling was used to select participants.
The study involved pregnant women between 24-36 weeks of gestation. The participants
completed the demographic questionnaire and Cohen's perceived stress scale in a self-reported and
written form. The cut point of 21.8 indicated a high stress level. Univariate and multivariate regression
were used to determine the relationship between demographic-obstetric variables and perceived
stress levels. Statistical analysis was carried out using Stata-13 software. A significance level
of 0.05 was utilized in the analysis.

Results:
The mean stress score was 33.32 (9.51). Maternal perceived stress was higher with longer
gestational age, history of COVID-19 infection, or renting a house, increasing the stress score by
0.85, 7.68, and 6.54, respectively.

Conclusion:
The study findings indicated that mothers with high-risk pregnancies experience high
levels of perceived stress, which intensifies as their gestational age progresses or if they contract
COVID-19 or have unstable housing. The results of this study can help policymakers, planners, and
healthcare providers, such as midwives and nurses, in creating and implementing programs to decrease
stress and its adverse effects in women with high-risk pregnancies.
An Insight into Disseminated Acute Encephalomyelitis Pathogenesis and Treatment -A Review
Authors: Nooreen Zulfa , Summayya Fariha , Wal Pranay , Wal Ankita , Rai Awani Kumar , Tandon Sudeep 
Published: June 2024

Background:
Acute disseminated encephalomyelitis (ADEM) is a neural and immunerelated
disorder that occurs when the cerebrospinal system is damaged by extensive swelling. Although
manifestation is possible regardless of age, adolescents have a greater probability. The purpose
of the present manuscript is to provide recent advancements and enhance knowledge of the disease

Method:
The literature search on etiology, pathophysiology, diagnosis and treatment was carried
out using the online databases of SciFinder, Medline, Pubmed, GoogleScholar, Scopus, etc.

Result:
Although the cause of ADEM remains unclear, it is believed to be caused by inflammation in those with a genetic sensitivity to environmental stimulation. When people have altered
levels of awareness or multifocal neurological abnormalities, ADEM is a possibility as a diagnosis. The diagnosis of ADEM is dependent on a combination of clinical and radiologic symptoms,
whereas the exclusion of illnesses mimics ADEM; there is no one test that can establish the diagnosis. The inflammation in a child's brain and spinal cord is treated with medication. Prednisone is occasionally given to youngsters for a brief amount of time.

Conclusion:
Most children with ADEM improve with high doses of methylprednisolone. Cyclophosphamide is needed by individuals with hypothermia. Most investigations show that 50%-
75% of individuals completely recover between the first and sixth month of their condition.
A Comprehensive Review of n-butylidenephthalide: The Potential Therapeutic Effect and Possibility for Targeted Therapy
Authors: Swati  , Sarma Kangkan , Bhardwaj Ruchi , Chauhan Laxita , Sharma Ritika , Mal Payel 
Published: June 2024

:
n-Butylidene phthalide (N-BP) is a natural derivative obtained from the chloroform extract
of Angelica Sinensis. In conventional medicine, it treats different ailments. Various pharmacological
properties are associated with it, including anticancer, anti-inflammatory, and neuroprotective
properties. Based on its reported pharmacokinetic profile, n-BP has low oral bioavailability and is
rapidly absorbed and eliminated from the body. The compound has diverse pharmacological effects
with lower stability, bioavailability, rapid absorption, and elimination. Furthermore, a targeted drug
delivery system using a nanocarrier can improve pharmacokinetic-molecular profiling, specificity,
efficacy, personal approach, and drug resistance. This review summarizes and emphasizes the pharmacokinetics,
and pharmacology of n-butylidene phthalide, and the molecular targeting approach to
treat cancer, inflammation, Parkinsonism, excitotoxicity, and Alzheimer’s.
Advancements in Chemical Proteomics for Target Identification of Natural Products in Live Cells
Authors: Banday Abid H. , Ashraf Insha , Bashir Mudasir , Yousuf Aariya , Qayoom Basit , Ahmad Bhat Mysar , Nabi Saima , Maqbool Saima , Lone Muzaffar A. 
Published: June 2024

:
Natural products have evolved to interact with specific protein targets within cells, making
them valuable for various biological functions. Chemical proteomics, specifically the use of covalently
linked probes in live cells, allows for the identification of protein-binding partners or targets of
small molecules. Recent advancements in target identification of natural products have utilized affinity-
based probes and photo-affinity labeling techniques, enabling the capture of potential cellular
targets even when the interaction is reversible. This knowledge can aid in understanding molecular
pathways and developing new therapeutics for diseases lacking treatment options. Several methods,
including DARTS, SPROX, CETSA, TPP, and bioinformatics-based analysis, are employed for target
identification of label-free natural products. Chemical probe design and synthesis are tailored to
screen targets of molecules with diverse structures. The comprehensive proteomic analysis reported
herein aims to investigate target sites contributing to biologically significant effects, considering both
desirable phenotypes and potential toxicity or side effects.
Role of Polyphenols to Attenuate Depressive Disorders and Cognitive Impairments Associated with Diabetes Mellitus – A Comprehensive Review
Authors: Ray Chowdhury Sejuti , Ghosh Sourav , Rahaman Monosiz , Dutta Srabona 
Published: June 2024

:
Diabetes Mellitus and its associated brain disorders become more prevalent across the
globe. Several comorbidity factors are associated with diabetic mellitus as well as the nervous system.
Static molecular variations in the Central Nervous System (CNS) due to Hyperglycemia may be
a major cause of psychiatric disorders. Carbohydrates and proteins imbalance as metabolic parameters
impact the downregulation of neurotransmitters in the brain region. Glucose metabolism has a
key role in brain physiology as well as in neuro-energetics, transmission, and defensive mechanisms
of the brain. Several studies revealed that CNS-acting medications overstated the glucose homeostasis
associated with brain functioning as well as pharmacological effects. Polyphenols are an assembly
of plant-derived composites with anti-inflammatory properties working on the inflammatory
markers as well as antioxidant possessions that decrease the oxidative stress that is accompanied by a
low pervasiveness of metabolic conditions categorized by insulin resistance. Those Natural products
influenced the molecular signaling pathway, which is directly related to depression, cognitive impairment
and neurotransmission. Currently, there are not any exact pharmacotherapies accessible for
CNS form-induced diabetes. However, around some prebiotics, probiotics with natural remedies
show promise in treating these central nervous system difficulties. Consequently, proof-based research
concluded the translational study with a clinical setting understanding the connotation among
brain glucose homeostasis and central nervous system complications is warranted, and the progress
of pharmacologically dynamic therapy for active treatment of comorbidities diseases related to diabetes
mellitus.
Metabolites with Anti-acetylcholinesterase Activities from Marine Mesophotic Zone Halichondria Sponge-associated Fungus Chaetomium sp. NBUF152
Authors: Wu Jiabin , Zou Jiabin , Wang Hongkun , Tian Jiaxin , Wei Tingting , Ran Guangjun , Wang Ping , Yan Pengcheng , Wang Tingting 
Published: June 2024

Background:
Mesophotic coral ecosystems (MCEs) are light-dependent ecosystems
found from 30 to 150 m in depth that are highly diverse and relatively understudied worldwide.

Methods:
One new indole alkaloid, chaetoid A (1), one known analog, indigodole B (2), and one
known β-carboline type alkaloid 1-acetyl-β-carboline (3), along with three known cyclic depsipeptides,
turnagainolide A (4), turnagainolide B (5), arthroamide (6)—were isolated from cultures of
fungus Chaetomium sp. NBUF152 is associated with a 66 m deep mesophotic zone Halichondria
sponge. Their structures were determined by analysis of spectroscopic data (NMR, HRESIMS, UV,
IR, optical rotation, and ECD). The in vitro bioassay results showed that compounds 1-6 exhibited
moderate inhibition against acetylcholinesterase (AchE).

Results:
The results showed that these compounds displayed moderate anti-AchE activities with IC50
values of 25.97 μmol/L, 25.80 μmol/L, 21.07 μmol/L, 23.49 μmol/L and 21.28 μmol/L, 25.3 μmol/L.

Conclusion:
This work could lead to additional investigation into the potential of marine organisms
in MCEs as a source for discovering natural products with interesting structures and bioactivities.
Effect of Multi-trace Elements Supplementation on Biochemical Markers and Postoperative Outcome in Patients Undergoing Elective Cardiac Surgery
Authors: Amirizadeh Mehran , Eslami Gohar , Shafaei-Bajestani Negar , Soleimani Aria , Habtemariam Solomon , Hashemi Javad , Sahebnasagh Adeleh 
Published: June 2024

Background:
Coronary Artery Bypass Graft (CABG) surgery is employed to increase
the lifespan of patients with Coronary Artery Disease (CAD). The low serum levels of essential elements
have a negative effect on patients undergoing CABG.

Objective:
This clinical trial aimed to investigate the effect of trace elements supplements on postoperative
outcomes after coronary artery bypass graft.

Methods:
Two hundred patients underwent on-pump CABG to randomly receive either
Addamel©, which contains essential trace elements, or isotonic saline for 3 days. We measured
postoperative plasma Zn, Se, Cu, Mn, Se, and Fe concentrations, and the levels of highly sensitive
C-reactive Protein (hs-CRP) on days 0, 1, and 2. Duration of hospital and Intensive Care Unit
(ICU) stay, 30-day mortality, and the incidence of Arterial Fibrillation (AF) have been evaluated
as secondary outcomes.

Results:
In the supplemented group, the plasma levels of Cu and Mn increased by day 3, and plasma
hs-CRP increased by day 1 in both groups, but it decreased in patients who received trace elements
supplementation on day 2. The Addamel group had a lower mortality rate, though the difference
did not reach a significant level. There was a significant negative correlation observed between
plasma Zn level and 30-day mortality, along with another significant negative link between
plasma CRP level before operation and Sepsis-related Organ Failure Assessment (SOFA) score.
Other measured parameters were similar between the intervention and placebo groups.

Conclusion:
The patients undergoing CABG appeared to benefit from trace element supplementation.
A brief period of Addamel administration following CABG could prevent a decrease in the
serum concentration of trace elements and reduce the circulating plasma CRP
Symptomatic Treatment of Extrapyramidal Hyperkinetic Movement Disorders
Authors: Boer Gregory de , Alfonsius de Bie Robertus Maria , Sylvain Swinnen Bart Erik Kris 
Published: June 2024

:
Extrapyramidal hyperkinetic movement disorders comprise a broad range of phenotypic
phenomena, including chorea, dystonia, and tics. Treatment is generally challenging and individualized, given the overlapping phenomenology, limited evidence regarding efficacy, and concerns regarding the tolerability and safety of most treatments. Over the past decade, the treatment has become even
more intricate due to advancements in the field of deep brain stimulation as well as optimized dopamine-depleting agents. Here, we review the current evidence for treatment modalities of extrapyramidal hyperkinetic movement disorders and provide a comprehensive and practical overview to aid the
choice of therapy. Mechanism of action and practical intricacies of each treatment modality are discussed, focusing on dosing and adverse effect management. Finally, future therapeutic developments
are also discussed.
Real-World Outcomes of a Digital Behavioral Coaching Intervention to Improve Employee Health Status: Retrospective Observational Study
Authors: Abdul Aziz Amani Fadzlina , Ong Tiffanie 
Published: June 2024

Background
Chronic noncommunicable diseases (NCDs) account for major disability and premature mortality worldwide, with low- and middle-income countries being disproportionately burdened. Given the negative impact of NCDs on employee performance and work productivity, there is a rising need for stakeholders to identify effective workplace solutions that can improve employee health outcomes. As the workplace becomes more dispersed post pandemic, digital behavioral coaching offers a scalable, personalized, and cost-effective method of managing chronic disease risk factors among employees.

Objective
This study aimed to retrospectively evaluate the impact of a digital behavioral coaching program on year-to-year changes in employee health status in a cohort of Indonesian employees.

Methods
This retrospective real-world exploratory analysis of secondary health data followed 774 employees of an Indonesian company who completed company-sponsored health screenings between 2021 and 2022 and were given access to Naluri (Naluri Hidup Sdn Bhd), a holistic digital therapeutics platform offering digital behavioral health coaching and self-help tools. Participants were retrospectively classified as those who received active coaching (n=177), passive coaching (n=108), and no coaching (n=489). Linear mixed-effects models were used to evaluate the year-to-year changes in health outcomes across the 3 employee groups, with post hoc analyses evaluating within-group differences between the 2 time points and between-group differences at follow-up.

Results
Significant time×group interaction effects were detected for body weight, BMI, hemoglobin A1c, low-density lipoprotein, total cholesterol, and systolic and diastolic blood pressure. Post hoc pairwise comparisons revealed significant improvements in hemoglobin A1c (mean difference [Mdiff]=–0.14, P=.008), high-density lipoprotein (Mdiff=+2.14, P<.001), and total cholesterol (Mdiff=–11.45, P<.001) for employees in the Active Coaching group between 2021 and 2022, with the other 2 groups reporting deteriorations in multiple health outcomes throughout the 2 time points. At follow-up, those who received active coaching between 2021 and 2022 reported significantly lower body weight (P<.001), BMI (P=.001), low-density lipoprotein (P=.045), and total cholesterol (P<.001) than the No Coaching group.

Conclusions
This study demonstrates real-world outcomes and implications supporting the use of workplace digital behavioral coaching in improving employee health status. Given the rising burden of NCDs in the Southeast Asian region, our findings underscore the role that workplace digital health interventions can play in preventing and managing chronic disease risk factors.
Argumentation in the genre “Opinion”: the main characteristics
Authors: Никонова Е.А. 
Published: June 2024

В статье рассматривается характер аргументации в жанре «мнение». Анализ показал, что такие черты жанра, как нацеленность на трансляцию авторского мнения и высокая степень субъективности, во многом определяют специфику аргументации. В результате было установлено, что в текстах мнения превалирует слабая аргументация, как в процентном соотношении, так и по количеству видов аргументов. Кроме того, было определено, что аргументы, как правило, носят пограничный характер и могут в ряде случаев выступать как в качестве сильных, так и слабых аргументов.
The article dwells on special characteristics of argumentation in the genre “opinion”. The opinion is aimed at translation of the author’s opinion and is highly subjective. These traits significantly affect the argumentation. The results of the analysis demonstrate that weak argumentation prevails. Moreover it has been discovered that most arguments can be used both as weak and strong ones, which depends on the author’s objectives. Keywords: mass media genres, opinion, op-ed, argumentation
Translation error as a representation of interpreter’s language personality: lexical and semantic aspect
Authors: Уланова Е.Э. 
Published: June 2024

В статье автор рассуждает о природе переводческой ошибки в устном переводе. Актуальность тематики обусловлена новаторским подходом к анализу переводческой ошибки, который реализуется за счет анализа переводческих ошибок на лексико-семантическом уровне как отражение языковой личности устного переводчика, наблюдаемое непосредственно в ситуации перевода. Автор определяет единицу анализа устного синхронного перевода и рассуждает о причинах возникновения переводческих ошибок, наблюдаемых непосредственно при анализе видеофрагментов синхронного перевода интервью.
In the article, the author discusses the nature of translation error in interpreting. The relevance of the topic is due to the non-standard approach to the analysis of the translation error. The author's innovative solution is to analyze the translation errors at the lexical-semantic level from the point of view of the interpreter's linguistic personality. The author defines the unit of analysis in simultaneous interpretation and discusses the causes of translation errors when analyzing videos of simultaneous interpretation.