bluuebunny/crossref_metadata_2025_split huggingface dataset:
Synthesis of 1,3‐oxazepine derivatives via tandem reaction of 5‐benzylidine Meldrum's acids with TosMIC in presence of potassium carbonate
Authors: Aslanoglu Furgan 
Published: June 2024

AbstractA new and efficient method for synthesizing 1,3‐oxazepines has been developed. The synthetic strategy of this method is based initially on the Knoevenagel reaction to form 5‐benzylidine Meldrum's acid, followed by a 7‐endo‐cyclization reaction with TosMIC (p‐toluenesulfonylmethyl isocyanide) in the presence of base. In the optimization studies carried out on this tandem reaction, the highest yield was obtained when K2CO3 was used as the base.
Single‐tube, single‐strip lateral flow assays utilizing loop‐mediated isothermal amplification for simultaneous hepatitis B and C viral detection
Authors: Guo Jing‐Wen , Ho Hsin‐Ying , Dai Chia‐Yen , Chen Yen‐Hsu , Yu Ming‐Lung , Yu Ling‐Shan 
Published: June 2024

AbstractGlobally, hepatitis B virus (HBV) affects over 250 million people, whereas hepatitis C virus (HCV) affects approximately 70 million people, posing major public health challenges. Despite the availability of vaccines and treatments, a lack of comprehensive diagnostic coverage has left many cases undiagnosed and untreated. To address the need for sensitive, specific, and accessible diagnostics, this study introduced a multiplex loop‐mediated isothermal amplification assay with lateral flow detection for simultaneous HBV and HCV testing. This assay achieved exceptional sensitivity and was capable of detecting HBV and HCV concurrently in a single tube and on a single strip within 25 min, achieving the required clinical sensitivity (10 and 103 genomic copies/reaction for HBV and HCV, respectively). The method was validated in clinical samples of various viral genotypes, achieving an equivalent limit of detection. Additionally, a custom portable heating device was developed for field use. The assay developed here, capable of direct viral detection on the strip, shows promise in supplanting current methods that solely identify antibodies and necessitate additional qPCR for viral activity assessment. This economical and rapid assay aligns with point‐of‐care testing needs, offering significant advancements in enhancing viral hepatitis diagnostics in settings with limited resources.
Caregiver‐reported symptom burden and preferences for therapeutic goals in pediatric primary sclerosing cholangitis
Authors: Shifman Holly Payton , Hatchett Joanne , Pai Ruth‐Anne , Safer Ricky , Gomel Rachel , Vyas Mary , Li Michael , Lai Jennifer C. , Wadhwani Sharad I. 
Published: June 2024

AbstractThis study analyzed qualitative and quantitative survey responses from 51 pediatric primary sclerosing cholangitis (PSC) patients and caregivers using the PSC Partners Patient Registry–Our Voices survey. The most common symptoms reported by children/caregivers include: fatigue (71%), abdominal pain (69%), anxiety (59%), appetite loss (51%), insomnia (49%), and pruritus (45%). When experiencing symptoms at their worst, over half of patients/caregivers reported limitations in physically demanding activities (67%), work/school duties (63%), social life activities (55%), and activities for fun or exercise (53%). Over half of patients/caregivers expressed willingness to participate in clinical trials, however none reported ever participating in trials for new or investigational PSC drugs. This study revealed a substantial patient/caregiver‐reported symptom burden for children with PSC that impacts quality of life and limits access to clinical trials. Future efforts should focus on developing patient‐centered clinical endpoints for PSC trials, increasing trial availability for pediatric PSC patients, and reducing logistical barriers to trial involvement.
Rise and decline of Holocene tufas across Europe: exploring east/west and north/south similarities and differences in their development
Authors: Dabkowski Julie , Beaumont Léa 
Published: June 2024

ABSTRACTAn extended inventory of 82 well‐dated European calcareous tufas is used to discuss the timing and amplitude of their onset, maximum and decline; in particular differences from east to west and between the Mediterranean area and the rest of Europe. Eastern deposits start to develop and reach their maximum slightly earlier than western tufas. Strong east–west differences in the timing and intensity of the climatic improvement during the first half of the Holocene explain the earlier development of eastern tufas compared with the west. The strongest differences are observed between Mediterranean deposits and other European tufas both in their development and decline, whether all or only fluvial deposits are considered, reflecting the important decoupling between Mediterranean and mid‐latitude climate records. During the Late Holocene, the earlier and more pronounced tufa decline observed in European mid‐latitudes is likely to result from more intense and rapid deforestation compared with the Mediterranean region.
Derivation and Initial Validation of the Utility Function for the Hearing Utility Measure (HUM)
Authors: Dixon Peter R. , Shapiro Justin , McRackan Theodore R. , Feeny David , Cushing Sharon L. , Chen Joseph M. , Tomlinson George 
Published: June 2024

ObjectiveThe Hearing Utility Measure (HUM) is a replacement hearing attribute for the Health Utilities Index, Mark 3 (HUI‐3) designed to improve the responsiveness of utility estimates to changes in hearing‐related quality of life. The final development step is to derive the instrument's utility scoring function.MethodsResidents of Ontario, Canada, aged ≥18 years participated in standard gamble and visual analogue scale exercises. Valuations for levels (response options) within each domain, and for each domain relative to the other domains were elicited and used to generate a hearing utility function. The function outputs hearing utility ranging from 0 = ‘unable to hear at all’ to 1 = ‘perfect hearing’ for each of the 25,920 hearing states classifiable by the HUM. Performance was assessed relative to the criterion standard: directly elicited standard gamble utility. Distributions of HUM‐derived hearing utility were compared with legacy HUI‐3 derived estimates.ResultsA total of 126 respondents participated (mean age 39.2, range 18–85 years, 53% female [67/126]). The utility function performed well in the estimation of directly elicited utilities (mean difference 0.03, RMSE 0.06). Using the legacy HUI‐3, estimated hearing utility was 1.0 for 118/126 respondents (93.6%) compared with just 66/126 (52.4%) using the HUM.ConclusionThe new hearing attribute is capable of measuring variations in hearing utility not captured by the legacy HUI‐3, especially near the ceiling of hearing function. These findings justify its application and further work to study its measurement properties in hearing loss populations.Level of Evidence3 Laryngoscope, 134:4754–4762, 2024
Dopa Responsiveness in Parkinson's Disease
Authors: Gandhi Sacha E. , Nodehi Anahita , Lawton Michael A. , Grosset Katherine A. , Marshall Vicky , Ben‐Shlomo Yoav , Grosset Donald G. 
Published: June 2024

AbstractBackgroundDopaminergic responsiveness is a defining feature of Parkinson's disease (PD). However, there is limited information on how this evolves over time.ObjectivesTo examine serial dopaminergic responses, if there are distinct patterns, and which factors predict these.MethodsWe analyzed data from the Parkinson's Progression Markers Initiative on repeated dopaminergic challenge tests (≥24.5% defined as a definite response). Growth‐mixture modeling evaluated for different response patterns and multinomial logistic regression tested for predictors of these clusters.Results1525 dopaminergic challenge tests were performed in 336 patients. At enrolment, mean age was 61.2 years (SD 9.6), 66.4% were male and disease duration was 0.5 years (SD 0.5). 1 to 2 years after diagnosis, 48.0% of tests showed a definite response, but this proportion increased with longer disease duration (51.1–74.3%). We identified 3 response groups: “Striking” (n = 29, 8.7%); “Excellent” (n = 110; 32.7%) and “Modest” (n = 197, 58.6%). Significant differences were as follows: striking responders commenced treatment earlier (P = 0.02), were less likely to be on dopamine agonist monotherapy (P = 0.01), and had better cognition (P < 0.01) and activities of daily living (P = 0.01). Excellent responders had higher challenge doses (P = 0.03) and were more likely to be on combination therapy (P < 0.01).ConclusionThree distinct patterns of the dopaminergic response were observed. As the proportion of PD cases with definite dopa responsiveness increased over time, the initial treatment response may be an unreliable diagnostic aid.
Biallelic ZBTB11 Variants: A Neurodevelopmental Condition with Progressive Complex Movement Disorders
Authors: Ortigoza‐Escobar Juan Darío , Zamani Mina , Dorison Nathalie , Sadeghian Saeid , Azizimalamiri Reza , Alvi Javeria Raza , Sultan Tipu , Galehdari Hamid , Shariati Gholamreza , Saberi Alihossein , Leeuwen Lisette , Zifarelli Giovanni , Bauer Peter , d'Hardemare Vincent , Doummar Diane , Roze Emmanuel , Travaglini Lorena , Nicita Francesco , Ojea Ponce Núria , Zahraei Seyed Mohammadsaleh , Alabdi Lama , Tamim Abdullah , Hashem Mais O. , Ababneh Faroug , Morrow Michelle M , Curry Cynthia , Tam Allison , Ruedy Jessica , Bhambhani Vikas , Veith Regan , Strømme Petter , Efthymiou Stephanie , Alkuraya Fowzan S , Moreno‐De‐Luca Andres , Burglen Lydie , Houlden Henry , Maroofian Reza 
Published: June 2024

AbstractBackgroundBiallelic ZBTB11 variants have previously been associated with an ultrarare subtype of autosomal recessive intellectual developmental disorder (MRT69).ObjectiveThe aim was to provide insights into the clinical and genetic characteristics of ZBTB11‐related disorders (ZBTB11‐RD), with a particular emphasis on progressive complex movement abnormalities.MethodsThirteen new and 16 previously reported affected individuals, ranging in age from 2 to 50 years, with biallelic ZBTB11 variants underwent clinical and genetic characterization.ResultsAll patients exhibited a range of neurodevelopmental phenotypes with varying severity, encompassing ocular and neurological features. Eleven new patients presented with complex abnormal movements, including ataxia, dystonia, myoclonus, stereotypies, and tremor, and 7 new patients exhibited cataracts. Deep brain stimulation was successful in treating 1 patient with generalized progressive dystonia. Our analysis revealed 13 novel variants.ConclusionsThis study provides additional insights into the clinical features and spectrum of ZBTB11‐RD, highlighting the progressive nature of movement abnormalities in the background of neurodevelopmental phenotype.
Assessing physiological arousal and emotional valence during behavioral intervention for pediatric feeding difficulties: A pilot study
Authors: Phipps Laura E. , Arce Walker S. , Walker Seth G. , Gehringer James E. 
Published: June 2024

AbstractThis study's purpose is to introduce a new measurement system that objectively assesses the social validity of behavioral feeding intervention from the child's perspective via the concurrent measurement of two dimensions of emotion. To date, the primary measures of social validity for behavioral feeding intervention are caregiver treatment acceptability and satisfaction surveys. This is the first study to objectively measure two dimensions of emotion, physiological arousal and emotional valence, while children received behavioral intervention for feeding difficulties. Data collectors used a new open‐source data collection software, cometrics, developed to synchronize and record physiological and observational data. Physiological data was collected using a wearable biosensor and observers recorded an index of child happiness, unhappiness, or neither using definitions by Phipps et al. (2022) for six children with a pediatric feeding disorder. Two out of six children needed programmed habituation to the device before data collection. All children assented to wearing the device during data collection. Recorded indices mapped to separable physiological states using electrodermal activity and its constituent components, skin conductance responses and skin conductance level, in addition to skin temperature. Findings demonstrated the feasibility of measuring two dimensions of child emotions during behavioral feeding intervention and revealed that children's physiological responses were distinctly different during intervals scored as happy, unhappy, or neither. This new data collection system has implications for future research on the child's emotional experience of behavioral feeding treatment and increases the possibilities for improving clinical practice.
Development of the trainer skill evaluation scale for metacognitive training
Authors: Hosono Masahito , Ishigaki Takuma , Ikeda Naoya , Ishikawa Ryotaro , Nishiguchi Yuki , Mizukami Katsuyoshi 
Published: June 2024

AbstractAimThe purpose of this study is manifold: to develop a trainer skill rating scale for metacognitive training (MCT), to determine the difficulty level of the behavioral checklist, and to examine the reliability and validity of the MCT Trainer Skills Rating Scale.MethodIn Study 1, an MCT trainer skill behavior checklist was developed with expert staff members, and a questionnaire was administered to MCT trainers. Item categorization was identical to that used in previous studies. In Study 2, a video was used to conduct the survey. All subjects were given a 1‐hour training session, instructed on evaluating the MCT Trainer Skills Rating Scale, and asked to rate their trainer skills on a mock video designed for beginners and a mock video designed for advanced trainers.ResultIn Study 1, responses from 49 respondents were obtained. The survey results showed that 72 items were classified similarly to previous studies. In Study 2, two pairs were randomly selected, and weighted kappa coefficients were calculated for the sub‐items of the MCT Trainer Skills Rating Scale. High agreement was obtained with K = 0.71 and K = 0.73, indicating high reliability.ConclusionHigh reliability was obtained for all eight items of the MCT Trainer Skills Rating Scale created in this study. In addition, the video evaluation scores for the advanced trainer were significantly higher than those for the beginner trainer, suggesting that discriminant validity was confirmed among the criterion‐related validity. These results confirm that the scale has both high reliability and validity.
A Polycaprolactone‐Hydroxyapatite (PCL/HAp) Scaffold, Prepared from Blue Crab Shell (Portunus Pelagicus) Waste, for Bone Substitution Applications
Authors: Oktavia Ningrum Eva , Safari Azhar Imam , Ciptonugroho Wirawan , Sabar Sumiyyah , Suprapto Suprapto , Dwitama Karisma Achmad , Josef Kridanto Kamadjaja Michael , Anggi Margaretha Tamita , Ulayya Khoirummata'Addunya Nakhwah , Widiyanto Sinung 
Published: June 2024

AbstractThe fabrication of a biodegradable polycaprolactone (PCL)/hydroxyapatite (HAp) scaffold prepared from local waste blue crab shells (Portunus pelagicus) by melt spinning method was investigated. The effect of different KH2PO4 concentrations on the physico‐chemical properties of HAp is evaluated. Furthermore, the influence of PCL/HAp ratios on mechanical strength and particle size distribution is reported. The formation of HAp is confirmed by Infrared (IR) spectroscopy and X‐ray diffraction (XRD). The biocompatibility of the PCL/HAp composites was evaluated using MTT assay and mechanical tests. The results reveal that the increase in KH2PO4 concentration contributed to the higher yield of HAp. However, the crystal and particle sizes are relatively invariable. SEM micrograph shows that the HAp introduction into PCL improves the material‘s porosity. Moreover, adding 10 % HAp into the PCL matrix significantly improved the mechanical strength of the filament compared to commercial PCL. MTT assay exhibits above 90 % cell viability, implying that the prepared PCL/HAp composite is non‐toxic and biocompatible with artificial bone replacement. After all, this study demonstrates that PCL/HAp filament derived from local blue crab waste is highly promising as a bone scaffolding material.
Lithium‐ion Battery Safety Enhancement via Internal Multi‐Parameter Simulation of Thermal and Pressure Conditions
Authors: Wang Longning , Tao Yuanzhi , Yang Zehang , Jia Shuhai , Lin Zihan , Zhang Huajian , Xu Chong , Liu Mingyang , Li Zhenming , Wei Bin 
Published: June 2024

AbstractSafety incidents with lithium‐ion batteries have impeded the battery industry‘s progress. As internal battery reactions often precede visible symptoms, and traditional electrical parameters are insufficient for comprehensive state assessment and hazard prediction, this study utilized multi‐physics simulations to analyze non‐electrical parameters, focusing on temperature and pressure dynamics. Partial validation of the simulation results was achieved through temperature monitoring experiments under varying charge/discharge rates. The findings indicated that internal temperature uniformly increased, with higher rates leading to more pronounced rises, and identified that lithium dendrite formation and mechanical stress could initiate thermal runaway. To mitigate these risks, specific operational guidelines were suggested. The study also established a positive correlation between pressure changes and temperature, influencing the battery‘s volume. Temperature monitoring further validated the simulations′ precision. This research deepens the understanding of non‐electrical parameter functions during battery operation and provides scientific evidence for the prediction and prevention of lithium‐ion battery safety risks.
Synthesis, Electrochemical Studies and Theoretical Calculations of Sulfo‐Schiff Bases
Authors: Bozkurt Sema , Şahin Mustafa , Şahin Özlem , Taha Gülderen A. , Öztekin Yasemin 
Published: June 2024

AbstractIn this study, two different water‐soluble Schiff base ligands as sodium(Z)‐3((2,5‐dihydroxybenzylidene)amino)benzene sulfonate (SLI) ve sodium (Z)3‐((3,4‐dihydroxybenzylidene)amino)benzene sulfonate (SLII) were synthesized as a result of the condensation reaction of 3‐aminobenzenesulfonicacid containing sulfo group with 2,5‐dihydroxybenzaldehyde and 3,4‐dihydroxybenzaldehyde, respectively. The chemical structures of the synthesized Schiff base ligands were characterized by melting point determination, elemental analysis, FT‐IR and 1H‐NMR techniques. Electrochemical behaviors of synthesized SLI and SLII ligands were examined by cyclic voltammetry technique against Ag/AgCl/KCl(sat) at the glassy carbon electrode in Britton Robinson buffer solution, pH 5.0. Electrode surfaces modified with SLI and SLII ligands were characterized by cyclic voltammetry technique in the presence of ferrocene and potassium hexacyanoferrate (III) redox probes, water contact angle measurement, scanning electron microscope and atomic force microscope and compared with the data of the bare glassy carbon electrode surface. Theoretical calculations of SLI and SLII ligand were performed with Density Functional Theory (DFT) and compared with experimental results.
Cu(II)‐Catalyzed Green Synthesis of 1,4,5‐Trisubstituted‐1,2,3‐Triazoles from Chalcone Derivatives – Studies on Their Cytotoxicity Profile
Authors: Mondal Joydip , Sivaramakrishna Akella 
Published: June 2024

AbstractTriazoles are an important class of heterocyclic compounds due to their interesting structural features and versatile biological significance. In this regard, the present work highlights the synthesis of Cu(II)‐catalyzed 1,2,3‐trisubstituted triazoles through the cycloaddition of different chalcones with azides under neat methodology. A series of 16 triazole derivatives (3 a to 3 o) was prepared using 10 mol % Cu(II) complexes of 1,10‐phenanthroline and terpyridine‐based ligands as catalysts with moderate to excellent yields. All these derivatives were structurally analyzed by UV‐visible, infrared, 1H, 13C NMR and mass spectral data. The product, (4‐((4‐benzoyl‐5‐(4‐fluorophenyl)‐1H‐1,2,3‐triazol‐1‐yl) methyl)benzonitrile) (3 j) was structurally analyzed by single crystal XRD analysis. Also, the molecular structure of one of the catalysts, [Cu(Phen)2]2+(NO3−)2) was obtained by single crystal XRD analysis. Additional investigations of all these derivatives exhibited potential cytotoxic characteristics against MCF‐7 cancer cell lines. Among them, compounds 3 j, 3 i, 3 c, 3 d and 3 g facilitated the notable IC50 values. Moreover, the studies on the photophysical properties of synthesized derivatives showed the absorption bands in the range of 267–290 nm, depending on the nature of the substituent and the compounds 3 e and 3 f demonstrated the highest and lowest quantum yields as 0.05339 % and 0.01914 %, respectively.
Probing the Adsorption Sites of 5‐amino‐2‐mercaptobenzimidazole Conformations on Colloidal Gold Nanoparticles Investigated by SERS and DFT
Authors: Hussain Shafqat , Karim Shafqat , Pang Yoonsoo 
Published: June 2024

AbstractGold nanoparticles (AuNP) have shown great potential in biomedical applications due to their unique and tunable properties. Understanding the ligand conformation on AuNP has profound interest in nanoparticle research leading to a precise drug delivery system. Colloidal AuNPs were synthesized using trisodium citrate as reducing agent. Normal Raman spectrum (NRS) in solid and aqueous phase identifies that 5‐amino‐2‐mercaptobenzimidazole (5A2MBI) mainly exist as thione form. Surface enhanced Raman scattering (SERS) investigation of 5A2MBI depending on pH was performed to explore the adsorption mechanism of thiolate and thione conformations on AuNPs. Density functional theory (DFT) calculations were used to find the band assignments and molecular electrostatic potential (MEP) mapping to identify the electron rich site where metal can interact preferentially. Using SERS spectral analysis and DFT results, surface adsorption scheme was proposed. At basic pH, 5A2MBI adsorbs on AuNP as thiolate form bidentately via Sulfur and nitrogen atom of imidazole ring with tilted geometry. However, in acidic condition the thione form adsorbs on nanosurface with perpendicular orientation.
Investigation Of The Schottky Diode Performance of a new Diaminomaleonitrile‐Based Organic Material with D‐Π‐A Architecture
Authors: Erdoğan Musa , Rıza Deniz Ali , Çaldıran Zakir , Acar Murat 
Published: June 2024

AbstractIn this paper, firstly, a new organic material 9 containing triphenylamine (TPA) unit as an electron donor and diaminomaleonitrile (DAMN) unit as an electron acceptor and thiophene scaffold as a π‐linker bridge was designed for diode applications according to D‐π‐A architecture. The organic material 9 was synthesized in four reaction steps with excellent yield (94 %), and fully characterized by 1H NMR, 13C NMR, FTIR, and HRMS spectra. The diode performance properties of the obtained organic material were examined in detail. Current‐voltage (I–V) and capacitance‐voltage (C–V) measurements of this diode were carried out. As a result of the analysis of these measurements, the effect of the organic material used as the interface material on the electrical properties of the diode was analyzed.