bluuebunny/crossref_metadata_2025_split huggingface dataset:
Observing and modeling BMCC degradation by commercial cellulase cocktails with fluorescently labeled Trichoderma reseii Cel7A through confocal microscopy
Authors: Luterbacher Jeremy S. , Walker Larry P. , Moran‐Mirabal Jose M. 
Published: July 2012

AbstractUnderstanding the depolymerization mechanisms of cellulosic substrates by cellulase cocktails is a critical step towards optimizing the production of monosaccharides from biomass. The Spezyme CP cellulase cocktail combined with the Novo 188 β‐glucosidase blend was used to depolymerize bacterial microcrystalline cellulose (BMCC), which was immobilized on a glass surface. The enzyme mixture was supplemented with a small fraction of fluorescently labeled Trichoderma reseii Cel7A, which served as a reporter to track cellulase binding onto the physical structure of the cellulosic substrate. Both micro‐scale imaging and bulk experiments were conducted. All reported experiments were conducted at 50°C, the optimal temperature for maximum hydrolytic activity of the enzyme cocktail. BMCC structure was observed throughout degradation by labeling it with a fluorescent dye. This method allowed us to measure the binding of cellulases in situ and follow the temporal morphological changes of cellulose during its depolymerization by a commercial cellulase mixture. Three kinetic models were developed and fitted to fluorescence intensity data obtained through confocal microscopy: irreversible and reversible binding models, and an instantaneous binding model. The models were successfully used to predict the soluble sugar concentrations that were liberated from BMCC in bulk experiments. Comparing binding and kinetic parameters from models with different assumptions to previously reported constants in the literature led us to conclude that exposing new binding sites is an important rate‐limiting step in the hydrolysis of crystalline cellulose. Biotechnol. Bioeng. 2013; 110: 108–117. © 2012 Wiley Periodicals, Inc.
Systematic review and meta-analysis of wound dressings in the prevention of surgical-site infections in surgical wounds healing by primary intention
Authors: Walter C J , Dumville J C , Sharp C A , Page T 
Published: July 2012

AbstractBackgroundPostoperative surgical-site infections are a major source of morbidity and cost. This study aimed to identify and present all randomized controlled trial evidence evaluating the effects of dressings on surgical-site infection rates in surgical wounds healing by primary intention; the secondary outcomes included comparisons of pain, scar and acceptability between dressings.MethodsRandomized controlled trials comparing alternative wound dressings, or wound dressings with leaving wounds exposed for postoperative management of surgical wounds were included in the review regardless of their language. Databases searched included the Cochrane Wounds Group Specialised Register and Central Register of Controlled Trials, Ovid MEDLINE, Ovid Embase and EBSCO CINAHL from inception to May 2011. Two authors performed study selection, risk of bias assessment and data extraction, including an assessment of surgical contamination according to the surgical procedure. Where levels of clinical and statistical heterogeneity permitted, data were pooled for meta-analysis.ResultsSixteen controlled trials with 2594 participants examining a range of wound contamination levels were included. They were all unclear or at high risk of bias. There was no evidence that any dressing significantly reduced surgical-site infection rates compared with any other dressing or leaving the wound exposed. Furthermore, no significant differences in pain, scarring or acceptability were seen between the dressings.ConclusionNo difference in surgical-site infection rates was demonstrated between surgical wounds covered with different dressings and those left uncovered. No difference was seen in pain, scar or acceptability between dressings.
Targeting Tumour Proliferation with a Small‐Molecule Inhibitor of AICAR Transformylase Homodimerization
Authors: Spurr Ian B. , Birts Charles N. , Cuda Francesco , Benkovic Stephen J. , Blaydes Jeremy P. , Tavassoli Ali 
Published: July 2012

AbstractAminoimidazole carboxamide ribonucleotide transformylase/ inosine monophosphate cyclohydrolase (ATIC) is a bifunctional homodimeric enzyme that catalyzes the last two steps of de novo purine biosynthesis. Homodimerization of ATIC, a protein–protein interaction with an interface of over 5000 Å2, is required for its aminoimidazole carboxamide ribonucleotide (AICAR) transformylase activity, with the active sites forming at the interface of the interacting proteins. Here, we report the development of a small‐molecule inhibitor of AICAR transformylase that functions by preventing the homodimerization of ATIC. The compound is derived from a previously reported cyclic hexapeptide inhibitor of AICAR transformylase (with a Ki of 17 μM), identified by high‐throughput screening. The active motif of the cyclic peptide is identified as an arginine‐tyrosine dipeptide, a capped analogue of which inhibits AICAR transformylase with a Ki value of 84 μM. A library of nonnatural analogues of this dipeptide was designed, synthesized, and assayed. The most potent compound inhibits AICAR transformylase with a Ki value of 685 nM, a 25‐fold improvement in activity from the parent cyclic peptide. The potential for this AICAR transformylase inhibitor in cancer therapy was assessed by studying its effect on the proliferation of a model breast cancer cell line. Using a nonradioactive proliferation assay and live cell imaging, a dose‐dependent reduction in cell numbers and cell division rates was observed in cells treated with our ATIC dimerization inhibitor.
Systematic Multi‐Scale Model Development Strategy for the Fragrance Spraying Process and Transport
Authors: Heitzig M. , Rong Y. , Gregson C. , Sin G. , Gani R. 
Published: July 2012

AbstractThe fast and efficient development and application of reliable models with appropriate degree of detail to predict the behavior of fragrance aerosols are challenging problems of high interest to the related industries. A generic modeling template for the systematic derivation of specific fragrance aerosol models is proposed. The main benefits of the fragrance spraying template are the speed‐up of the model development/derivation process, the increase in model quality, and the provision of structured domain knowledge where needed. The fragrance spraying template is integrated in a generic computer‐aided modeling framework, which is structured based on workflows for different general modeling tasks. The benefits of the fragrance spraying template are highlighted by a case study related to the derivation of a fragrance aerosol model that is able to reflect measured dynamic droplet size distribution profiles for limonene.
Hydrogen‐Bonding‐Mediated Vesicular Assembly of Functionalized Naphthalene–Diimide‐Based Bolaamphiphile and Guest‐Induced Gelation in Water
Authors: Molla Mijanur Rahaman , Ghosh Suhrit 
Published: July 2012

AbstractThis paper describes the spontaneous vesicular assembly of a naphthalene–diimide (NDI)‐based non‐ionic bolaamphiphile in aqueous medium by using the synergistic effects of π‐stacking and hydrogen bonding. Site isolation of the hydrogen‐bonding functionality (hydrazide), a strategy that has been adopted so elegantly in nature, has been executed in this system to protect these moieties from the bulk water so that the distinct role of hydrogen bonding in the self‐assembly of hydrazide‐functionalized NDI building blocks could be realized, even in aqueous solution. Furthermore, the electron‐deficient NDI‐based bolaamphiphile could engage in donor–acceptor (D–A) charge‐transfer (CT) interactions with a water‐insoluble electron‐rich pyrene donor by virtue of intercalation of the latter chromophore in between two NDI building blocks. Remarkably, even when pyrene was located between two NDI blocks, intermolecular hydrogen‐bonding networks between the NDI‐linked hydrazide groups could be retained. However, time‐dependent AFM studies revealed that the radius of curvature of the alternately stacked D–A assembly increased significantly, thereby leading to intervesicular fusion, which eventually resulted in rupturing of the membrane to form 1D fibers. Such 2D‐to‐1D morphological transition produced CT‐mediated hydrogels at relatively higher concentrations. Instead of pyrene, when a water‐soluble carboxylate‐functionalized pyrene derivative was used as the intercalator, non‐covalent tunable in‐situ surface‐functionalization could be achieved, as evidenced by the zeta‐potential measurements.
Photoswitchable, DNA‐Binding Helical Peptides Assembled with Two Independently Designed Sequences for Photoregulation and DNA Recognition
Authors: Fujimoto Kazuhisa , Kajino Masaoki , Sakaguchi Ikumi , Inouye Masahiko 
Published: July 2012

AbstractDiarylethene‐bridged peptides were developed to photoregulate biomolecular interactions. The peptides are made up of diarylethene‐bridged and DNA‐binding regions at their N‐ and C termini, respectively. The two regions could be independently designed and combined as desired. The α‐helicities of the peptides were photoregulated in on/off or off/on manners, and the manner depended on the positions of two ornithine (Orn) residues for cross‐linking reaction at the diarylethene‐bridged region. In the case of the on/off manner, when the diarylethene structure adopted the open form on the peptides, the peptides folded into stable α‐helices. Upon UV irradiation, the diarylethene moiety isomerized to its closed form to destabilize the helical structures. Quartz crystal microbalance (QCM) analysis showed that the open isomer strongly associated with a target DNA, as compared with the closed one. When the closed‐form peptide existing in the DNA complex was irradiated with a fluorescent lamp in the middle of the QCM monitoring, the frequency change (ΔF) was enhanced by the diarylethene photoisomerization.
ChemInform Abstract: Polychloride Monoanions from [Cl3]‐ to [Cl9]‐: A Raman Spectroscopic and Quantum Chemical Investigation.
Authors: Brueckner Robin , Haller Heike , Ellwanger Mathias , Riedel Sebastian 
Published: July 2012

AbstractPolychloride monoanions [Cln]‐ (n = 3, 5, 7, 9) stabilized by quaternary ammonium salts are obtained through the addition or condensation of an excess of dry chlorine to [NMe4]Cl, [NEt4]Cl, [NPr4]Cl, or [NBu4]Cl and characterized by Raman spectroscopy and state‐of‐the‐art quantum chemical calculations up to the CCSD(T) level.
ChemInform Abstract: Boron Site Preference in Ternary Ta and Nb Boron Silicides.
Authors: Khan Atta U. , Nunes Carlos A. , Coelho Gilberto C. , Suzuki Paulo A. , Grytsiv Andriy , Bourree Francoise , Giester Gerald , Rogl Peter F. 
Published: July 2012

AbstractThe crystal structures of the ternary compounds in the metal‐rich part of the systems Nb—B—Si and Ta—B—Si are characterized by single crystal XRD or neutron powder diffraction to elucidate boron site preference.
ChemInform Abstract: Niobium(V) Oxynitride: Synthesis, Characterization, and Feasibility as Anode Material for Rechargeable Lithium‐Ion Batteries.
Authors: Wang Xiao‐Jun , Krumeich Frank , Woerle Michael , Nesper Reinhard , Jantsky Laurent , Fjellvaag Helmer 
Published: July 2012

AbstractNbO1.3N0.7 particles with about 5 mm diameter are synthesized by decomposition of NbOCl3(NH3)4.
ChemInform Abstract: Li2Sr4B12O23: A New Alkali and Alkaline‐Earth Metal Mixed Borate with [B10O18]6‐ Network and Isolated [B2O5]4‐ Unit.
Authors: Zhang Min , Pan Shilie , Han Jian , Yang Zhihua , Su Xin , Zhao Wenwu 
Published: July 2012

AbstractThe title compound is synthesized by solid state reaction of a stoichiometric mixture of Li2CO3, SrCO3, and H3BO3 (710 °C, 60 h).
ChemInform Abstract: Synthesis, Structure, and Properties of Li2In2MQ6 (M: Si, Ge; Q: S, Se): A New Series of IR Nonlinear Optical Materials.
Authors: Yin Wenlong , Feng Kai , Hao Wenyu , Yao Jiyong , Wu Yicheng 
Published: July 2012

AbstractThe isostructural compounds (III) crystallize in the noncentrosymmetric monoclinic space group Cc with Z = 4 (Cd4GeS6‐type structure; single crystal XRD).
ChemInform Abstract: A5Sn2As6 (A: Sr, Eu). Synthesis, Crystal and Electronic Structure, and Thermoelectric Properties.
Authors: Wang Jian , Xia Sheng‐Qing , Tao Xu‐Tang 
Published: July 2012

AbstractThe new ternary title Zintl phases of title are synthesized from the elements using Sn as a self‐flux (alumina crucible, 900 °C, 24 h).
ChemInform Abstract: Re‐Evaluating the Nucleophilicity of Zinc Enolates in Alkylation Reactions.
Authors: Jarugumilli Gopala K. , Zhu Chunyin , Cook Silas P. 
Published: July 2012

AbstractThe allylic and benzylic alkylation of zinc enolates, generated by asymmetric copper‐catalyzed conjugate addition of dialkylzinc (II) towards cyclic enones (I), with various electrophiles is described.
ChemInform Abstract: New Heterocyclic Compounds from 1,2,4‐Triazole and 1,3,4‐Thiadiazole Class Bearing Diphenylsulfone Moieties. Synthesis, Characterization and Antimicrobial Activity Evaluation.
Authors: Barbuceanu Stefania‐Felicia , Saramet Gabriel , Almajan Gabriela Laura , Draghici Constantin , Barbuceanu Florica , Bancescu Gabriela 
Published: July 2012

AbstractAll products are screened for their antimicrobial potency.
ChemInform Abstract: An Efficient and Chemoselective Deprotection of tert‐Butyldimethylsilyl (TBDMS) Ethers Using Tailor‐Made Ionic Liquid.
Authors: Jadhav Vinod H. , Lee Sang Bong , Jeong Hwan‐Jeong , Lim Seok Tae , Sohn Myung‐Hee , Kim Dong Wook 
Published: July 2012

AbstractVarious substrates bearing 2 protecting ‐OH functions are subjected to conditions A).
ChemInform Abstract: Enantioselective Synthesis of (R)‐ and (S)‐1‐2H‐1‐Octanol and Their Corresponding Amines
Authors: Balkenende Diederik W. R. , Cantekin Seda , Duxbury Christopher J. , van Genderen Marcel H. P. , Meijer E. W. , Palmans Anja R. A. 
Published: July 2012

Abstractinvolving the direct enzymatic reduction of octanal using alcohol dehydrogenases as biocatalyst and NADHP as cofactor in deuterated iPrOH as key step
ChemInform Abstract: Catalytic Effect and Recyclability of Imidazolium‐Tagged Bis(oxazoline) Based Catalysts in Asymmetric Henry Reactions.
Authors: Zhou Zhi‐Ming , Li Zhi‐Huai , Hao Xiao‐Yan , Zhang Jun , Dong Xiao , Liu Ying‐Qiang , Sun Wen‐Wen , Cao Dan , Wang Jin‐Liang 
Published: July 2012

AbstractThe new bisoxazoline promotes the reaction of a number of aldehydes with nitromethane and nitroethane.
ChemInform Abstract: One‐Pot, Direct Synthesis of Acyl Azides from Carboxylic Acids Using Ph2PCl/I2/NaN3 Reagent System.
Authors: Nowrouzi Najmeh , Jonaghani Mohammad Zareh 
Published: July 2012

AbstractThe reaction proceeds with aromatic as well as aliphatic carboxylic acids using low‐toxic reagents and providing easy work‐up.
ChemInform Abstract: Ireland—Claisen Rearrangement of Secondary Allyl Acetate Revisited: Inevitable C‐Silylation Circumvented by One‐Pot Application of Excessive LDA/TMSCl and TBAF.
Authors: Liu Di , Yu Xiaoming 
Published: July 2012

AbstractOptimized conditions A) allow the preparation of mixtures which contain the desired unsaturated rearranged acids and silylated analogues of type (III), where the latter are generally formed with higher yields.
ChemInform Abstract: N‐Heterocyclic Carbene Catalyzed Cyanomethylation of Aldehydes with TMSAN.
Authors: Fan Ye‐Cheng , Du Guang‐Fen , Sun Wan‐Fu , Kang Wei , He Lin 
Published: July 2012

AbstractA broad spectrum of aromatic aldehydes, 2 aliphatic aldehydes and ketone (VI) are subjected to the title reaction to produce the synthetically important building blocks with moderate to good yields.
ChemInform Abstract: Palladium Nanoparticle Catalysis: Borylation of Aryl and Benzyl Halides and One‐Pot Biaryl Synthesis via Sequential Borylation—Suzuki—Miyaura Coupling.
Authors: Bej Ansuman , Srimani Dipankar , Sarkar Amitabha 
Published: July 2012

AbstractBenzyl and aryl halides (I) and (IV) react readily with bis(pinacolato)diboron (II) in the presence of in situ generated palladium nanoparticles as catalyst and potassium acetate as a base.
ChemInform Abstract: CuSO4·5H2O: A Novel, Green, Reusable, and Environmentally Friendly Catalyst for the One‐Pot, Four‐Component Synthesis of β‐Acetamido Carbonyl Compounds.
Authors: Behbahani Farahnaz K. , Doragi Neda , Heravi Majid M. 
Published: July 2012

AbstractAdvantages of the title procedure are easy and safe handling, no toxicity, reusability of the catalyst and easy work‐up.
ChemInform Abstract: Enantioselective Synthesis of Chiral Propargylic Alcohols Catalyzed by Bifunctional Zinc‐Based Complexes.
Authors: Lu Xinhua , Xie Guanlei , Li Tingyi , Qu Xiaoming , Mao Jincheng 
Published: July 2012

AbstractThe AAS ligand is also tested in an asymmetric Henry reaction and a Michael addition, respectively.
ChemInform Abstract: Expedient Synthesis of Highly Substituted Pyrroles via Tandem Rearrangement of α‐Diazo Oxime Ethers.
Authors: Jiang Yaojia , Chan Wei Chuen , Park Cheol‐Min 
Published: July 2012

AbstractUnder rhodium‐catalysis and at the appropriate reaction temperature, the title oxime ethers of type (I) bearing a vinylcarbonyl moiety are transformed to highly substituted pyrroles.
ChemInform Abstract: Synthesis of Trisubstituted Isoxazoles by Palladium(II)‐Catalyzed Cascade Cyclization—Alkenylation of 2‐Alkyn‐1‐one O‐Methyl Oximes.
Authors: She Zhigang , Niu Dongyue , Chen Lei , Gunawan Maria A. , Shanja Xhesika , Hersh William H. , Chen Yu 
Published: July 2012

AbstractThe method represents a new, convenient, and widely applicable approach to the target compounds.
ChemInform Abstract: Stereodefined N,O‐Acetals: Pd‐Catalyzed Synthesis from Homopropargylic Amines and Utility in the Flexible Synthesis of 2,6‐Substituted Piperidines.
Authors: Kim Haejin , Rhee Young Ho 
Published: July 2012

AbstractA chiral ligand‐directed approach is used to obtain the N,O‐acetals as precursors for the target chiral tetrahydropyridines.
ChemInform Abstract: A Microwave‐Assisted Nucleophilic Substitution Reaction on a Quinoline System: The Synthesis of Amino Analogues of Nitroxoline.
Authors: Stefane Bogdan , Pozgan Franc , Sosic Izidor , Gobec Stanislav 
Published: July 2012

AbstractIt is demonstrated that a cyanomethoxy moiety serves as an efficient leaving group in nucleophilic aromatic substitution of the 5‐nitroquinoline system with primary and secondary amines.
ChemInform Abstract: Organocatalytic Asymmetric 1,4‐Addition of Aldehydes to Acridiniums Catalyzed by a Diarylprolinol Silyl Ether.
Authors: Liang Tao , Xiao Jian , Xiong Zhiyi , Li Xingwei 
Published: July 2012

AbstractThe title reaction allows an efficient and highly enantioselective access to 9‐substituted acridines such as (III).
ChemInform Abstract: Solvent‐Free and Efficient Synthesis of Imidazo[1,2‐a]pyridine Derivatives via a One‐Pot Three‐Component Reaction.
Authors: Wen Li‐Rong , Li Zhao‐Rui , Li Ming , Cao Han 
Published: July 2012

AbstractA variety of trans‐imidazopyridine derivatives (IV) (25 examples) is readily prepared by a three‐component reaction of five‐membered ketene aminals (I) with aldehydes (II) and dithioates (III) under solvent‐free conditions.
ChemInform Abstract: Synthesis of 5‐Fluorovinyl Derivatives of Pyrimidines via Suzuki—Miyaura Coupling and Their 1,3‐Dipolar Cycloaddition Reactions with Nitrones.
Authors: Wojtowicz‐Rajchel Hanna , Koroniak Henryk 
Published: July 2012

AbstractThis simple synthesis of a new class of isoxazolidine derivatives is based on the reaction of fluorovinyl pyrimidines (III), which are obtained by Suzuki—Miyaura coupling, with nitrones (IV).
ChemInform Abstract: Switchable Selectivity in Multicomponent Heterocyclizations of Acetoacetamides, Aldehydes, and 3‐Amino‐1,2,4‐triazoles/5‐aminopyrazoles.
Authors: Muravyova Elena A. , Desenko Sergey M. , Rudenko Roman V. , Shishkina Svetlana V. , Shishkin Oleg V. , Sen'ko Yulia V. , Vashchenko Elena V. , Chebanov Valentin A. 
Published: July 2012

AbstractThe direction of the process depends on the temperature regime and on the structure of the starting materials.
ChemInform Abstract: Substitution at C‐4 in 3,5‐Disubstituted 4H‐1,2,6‐Thiadiazin‐4‐ones.
Authors: Ioannidou Heraklidia A. , Koutentis Panayiotis A. 
Published: July 2012

AbstractThe absorption properties of the compounds (I), (V), (VIII), (X), (XI), and (XIII) are investigated in CH2Cl2.
ChemInform Abstract: Sesquiterpenoids from Atractylodes macrocephala Act as Farnesoid X Receptor and Progesterone Receptor Modulators.
Authors: Tsai Chia‐Jui , Liang Jui‐Wei , Lin Hsiang‐Ru 
Published: July 2012

AbstractAtractylenolide II (Ia) and III (Ib) act both as farnesoid X receptor (FXR) antagonists and (Ib) also behaves as progesterone receptor (PR) agonist.
ChemInform Abstract: HSAB‐Driven Regioselectivity Difference in the Lewis Acid Catalyzed Reactions of 2‐C‐Substituted Glycals with Sulfur and Oxygen Nucleophiles: Direct versus Allylic Substitution.
Authors: Nagaraj Paramathevar , Ramesh Namakkal G. 
Published: July 2012

AbstractThe reaction of 2‐C‐substituted glycals with thiophenols leads to preferential formation of a new class of compounds viz.
ChemInform Abstract: A Novel Antifouling Alkaloid from Halotolerant Fungus Penicillium sp. OUCMDZ‐776.
Authors: He Fei , Liu Zhong , Yang Jing , Fu Peng , Peng Jiang , Zhu Wei‐Ming , Qi Shu‐Hua 
Published: July 2012

AbstractPenispirolloid A (I) exhibits significant effects toward Bugula neritina larvae.
ChemInform Abstract: Acetylenic Acid Analogues from the Edible Mushroom Chanterelle (Cantharellus cibarius) and Their Effects on the Gene Expression of Peroxisome Proliferator‐Activated Receptor‐γ Target Genes.
Authors: Hong Seong Su , Lee Ji Hae , Jeong Wonsik , Kim Nahyun , Jin Hui Zi , Hwang Bang Yeon , Lee Hak‐Ju , Lee Sung‐Joon , Jang Dae Sik , Lee Dongho 
Published: July 2012

AbstractThe new acetylenic acid (I) specifically activates peroxisome proliferator‐activated receptor (PPAR)‐γ with an EC50 value of 1.88 μM.
ChemInform Abstract: Crystal Phase‐Controlled Synthesis of Cu2FeSnS4 Nanocrystals with a Band Gap of Around 1.5 eV.
Authors: Zhang Xiaoyan , Bao Ningzhong , Ramasamy Karthik , Wang Yu‐Hsiang A. , Wang Yifeng , Lin Baoping , Gupta Arunava 
Published: July 2012

AbstractCu2FeSnS4 nanocrystals with the wurtzite structure are synthesized by quick injection of a mixture of 1‐dodecanethiol and tert‐dodecanethiol into a mixture of Cu(acac)2, Fe(acac)3, SnCl4, and oleylamine (210 °C, 30 min).
Cis‐Diastereoselectivity in Pictet–Spengler Reactions of L‐Tryptophan and Electronic Circular Dichroism Studies
Authors: Rashid Naghmana , Alam Samina , Hasan Mashooda , Khan Naeema , Khan Khalid M. , Duddeck Helmut , Pescitelli Gennaro , Kenéz Ágnes , Antus, Sándor , Kurtán Tibor 
Published: July 2012

ABSTRACTThe diastereoselective synthesis of optically active 1,3‐disubstituted tetrahydro‐β‐carbolines using polar protic Pictet–Spengler cyclization of (S)‐tryptophan methyl ester with five aldehydes RCHO (R═CH3, C2H5, C3H7, C4H9, and C6H5) was studied. As an alternate route, the cyclization of (S)‐tryptophan with the same aldehydes and subsequent methylation of the resulting tetrahydro‐β‐carboline carboxylic acids were also performed for comparison. 13C NMR and electronic circular dichroism (ECD) studies and time‐dependent density functional theory ECD calculations data established the relative 1,3 cis/trans and the absolute configuration (1S,3S/ 1R,3S) of the synthesized compounds. The solid‐state and solution ECD study of the prepared compounds, supported by ECD calculation and X‐ray data, afforded a reliable ECD method for the configurational assignment of 1,3‐disubstituted tetrahydro‐β‐carbolines and revealed the stereochemical factors that determine the characteristic ECD data. Chirality 24:789–795, 2012. © 2012 Wiley Periodicals, Inc.