bluuebunny/crossref_metadata_2025_split huggingface dataset:
PENENTUAN HARGA DALAM JUAL BELI JAGUNG TEBASAN PERSPEKTIF HUKUM EKONOMI SYARIAH
Authors: Mustaghfiroh Siti , Widiastuti Mila 
Published: April 2024

Jual beli dengan cara tebasan sudah ada sejak zaman dahulu. Sistem jual beli ini biasanya digunakan untuk memudahkan para penebas. Penentuan harga jual beli tebasan sekarang banyak terjadi dikalangan masyarakat yang menjual dengan cara tebasan dan menjadi permasalahan para petani dalam penentuan harganya. Terkadang petani memilih memanen hasil panen nya sendiri dibandingkan dengan sistem tebasan, karena harga yang menjadi penentuan jual beli.Penelitian ini bertujuan untuk mengetahui penentuan harga jual beli tebasan menurut hukum ekonomi syariah di Desa Giriklopomulyo Kecamatan Sekampung. Jenis penelitian ini adalah penelitian lapangan (field research). Sedangkan sifat penelitiannya bersifat deskriptif. Sumber data yang digunakan adalah sumber data primer dan sekunder. Pengumpulan data dilakukan dengan menggunakan teknik wawancara, observasi, dan dokumentasi. Data hasil temuan digambarkan secara deskriptif dan dianalisis menggunakan cara berpikir induktif. Hasil penelitian ini menunjukkan bahwa sistem penentuan harga dalam jual beli jagung tebasan di Desa Giriklopomulyo Kecamatan Sekampung Kabupaten Lampung Timur sesuai dengan hukum ekonomi syariah karena dalam jual beli sistem tebasan yang ada di Desa Giriklopomulyo ini tidak mengandung unsur gharar yang ada hanyalah resiko kerugian kecil. Resiko merupakan hal yang lumprah dalam jual beli karena resiko datang di luar kehendak manusia. Dalam jual beli tersebut baik penebas maupun pemilik lahan juga mengaku saling ridha. Penebas merupakan orang yang ahli, sehingga perkiraan mereka selalu benar dan jarang sekalin salah. Jual beli jagung dengan sistem tebasan yang terjadi di Desa Giriklopomulyo sah menurut hukum Islam karena sesuai dengan rukun dan syarat pembeli. Kesesuain jual beli tebasan jagung jika dilihat sudut pandang hukum ekonomi telah sesuai. Jual beli tebasan jagung yang dilarang dalam hukum ekonomi syariah yaitu jual beli yang mengandung unsur gharar. Untuk pembayarannya porsekot diperbolehkan dengan tujuan agar terjadi perikatan, tapi dilarang apabila terjadi pembatalan jual beli porsekot hangus oleh penjual. Jual beli tebasan dengan uang tunai ketika panen ini merupakan jual beli yang paling sah diantara ketiga bentuk jual beli tebasan, karena keadilan dapat tercapai.
IMPROVING SCIENCE PROCESS SKILLS USING GUIDED INQUIRY-BASED STUDENT WORKSHEET
Authors: Mahyuna  , Putri Deviyani Rusdiyanti , Hasja Yusrizal , Nuhari Insan , Azzarkasyi Muhammad 
Published: April 2024

The use of conventional student worksheets, such as those from publishing companies, the internet, or the ready-made ones where the teacher is not involved in the planning, or preparation process, can cause students to be less active in learning and not meet the needs of students and their learning objectives. This can be overcome by using guided inquiry-based student worksheets, which can increase students' creativity. This student worksheet is very suitable for the needs of students. This paper aims to describe guided inquiry-based student worksheets to improve the science process skills through a review of relevant literature. The results of the literature review explain that guided inquiry-based student worksheets can improve students' science process skills because they are can practice hypothesizing, identifying tools and materials, analyzing data, and concluding investigation results. Based on the results of literary studies, it can be concluded that guided inquiry-based student worksheets can have a positive effect on science learning.
PENGARUH HARGA DAN KUALITAS PELAYANAN TERHADAP KEPUASAN PELANGGAN PADA GROSIR SEMBAKO TOKO ADA HARAPAN
Authors: Amri Riki Chairul , Lidiya W , Safriansyah Safriansyah 
Published: April 2024

Penelitian bertujuan untuk (1) mengetahui tingkat kepuasan yang diterima konsumen dari harga dan kualitas pelayanan yang dilakukan toko Ada Harapan, (2) mengetahui variabel mana yang paling dominan mempengaruhi kepuasan konsuman Toko Ada Harapan. Dalam penelitian ini yang menjadi variabel dependen adalah : kepuasan konsumen (Y). Variabel independen dalam penelitian ini adalah : Harga produk (X1), Kualitas pelayanan (X2). Teknik pengumpulan data yaitu dengan kuesioner dan observasi. 1. Berdasarkan analisis diskriptif dapat diketahui memberikan penilaian baik hal tersebut disesuaikan interval yang ada dimana kualitas pelayanan yaitu dengan skor rata-rata sebesar 3,81 (baik) dan harga yaitu dengan skor rata-rata 3,84 (baik). Serta penilaian responden pada variabel kepuasan konsumen dengan skor rata-rata sebesar 3,90 (baik). Hasil analisis regresi berganda dapat kita simpulkan bahwa kualitas pelayanan (X1) dapat mempengaruhi kepuasan konsumen dengan koefisien regresi sebesar 0,007 dan harga (X2) dapat mempengaruhi kepuasan konsumen dengan koefisien regresi sebesar 0,034. Hasil uji korelasi berganda (R) dapat diketahui bahwa setiap terjadi kenaikan pada variabel kualitas pelayanan dan harga produk maka akan meningkatkan kepuasan konsumen secara rata-rata sebesar 74,7%. Dan dari hasil uji koefisien determinasi berganda (R2) varibel kualitas pelayanan dan harga produk secara Bersama mempengaruhi kepuasan konsumen sebesar 55,8% sedangkan sisanya sebesar 54,2% dipengaruhi variabel lain dapat berupa citra merek, lingkungan, dan iklan.Sehingga dapat disimpulkan bahwa variabel kualitas pelayanan memiliki pengaruh yang paling dominan terhadap kepuasan konsumen.
ADVERSITY INTELLIGENCE DAN PENGETAHUAN KEWIRAUSAHAANTERHADAP INTENSI BERWIRAUSAHA (Studi Pada Mahamahasiswa Ekonomi dan Bisnis padaPerguruan Tinggi di Kota Lubuklinggau)
Authors: Syahrani Tiara , Pradesa Endar 
Published: April 2024

Penelitian ini bertujuan untuk menguji secara empiris pengaruh adversity intelligence dan pengetahuan kewirausahaan terhadap intensi berwirausaha. Populasi dalam penelitian ini adalah seluruh mahasiswa ekonomi dan bisnis pada perguruan tinggi di Kota Lubuklinggau. Sampel dalam penelitian ini berjumlah 98 responden.Data yang digunakan adalah data primer yang diperoleh dari hasil penyebaran kuesioner kepada mahasiswa ekonomi dan bisnis pada perguruan tinggi di Kota Lubuklinggau. Metode yang digunakan adalah analisis regresi linier sederhana dan berganda. Hasil penelitian yaitu adversity intelligence berpengaruh signifikan terhadap intensi berwirausaha pada mahasiswa ekonomi dan bisnis pada perguruan tinggi di Kota Lubuklinggau. Hal ini dibuktikan dengan nilai thitung = 4,247 > nilai ttabel = 1,660 dengan nilai signifikan 0,000 < 0,05. Pengetahuan kewirausahaan berpengaruh signifikan terhadap intensi berwirausaha pada mahamahasiswa ekonomi dan bisnis pada perguruan tinggi di Kota Lubuklinggau. Hal ini dibuktikan dengan nilai thitung = 4,917> nilai ttabel = 1,660 dengan nilai signifikan 0,000 < 0,05. Adversity intelligence dan pengetahuan kewirausahaan berpengaruh signifikan terhadap intensi berwirausaha pada mahamahasiswa ekonomi dan bisnis pada perguruan tinggi di Kota Lubuklinggau. Hal ini dibuktikan dengan nilai Fhitung = 14,516 > nilai Ftabel = 3,090 dengan nilai signifikan 0,000 < 0,05.
PENGARUH SOSIAL MEDIA MARKETING DAN KUALITAS PRODUK TERHADAP KEPUASAN PELANGGAN DI THE WRAPPERS, MEDAN
Authors: Jaya Chairman Lawvandy , Tampubolon Mangihut 
Published: April 2024

The Wrappers merupakan sebuah toko online berbasis culinary & healthy yang berlokasi di Jalan Pukat 1 No. A5 Medan, Sumatera Utara. Tujuan dari penelitian ini adalah untuk mengetahui adakah Pengaruh Sosial Media Marketing dan Kualitas Produk Terhadap Kepuasan Pelanggan The Wrappers, Medan. Populasi dalam penelitian ini adalah sebanyak 118 pelanggan dengan menghitung ukuran sampel yang dilakukan dengan menggunakan teknik slovin. Hasil penelitian adalah adanya pengaruh antara Sosial Media Marketing dan Kualitas Produk terhadap Kepuasan Pelanggan The Wrappers, Medan. Koefisien regresi variabel (b) sosial media marketing dan kualitas produk sebesar 0,881 dan 0.889 artinya jika sosial media marketing dan kualitas produk mengalami kenaikan 1% maka kepuasan pelanggan sebesar 0,881 dan 0.889. Dari hasil koefisien determinasi sebesar 71%. Angka ini menunjukkan bahwa kepuasan pelanggan dipengaruhi oleh sosial media marketing dan kualitas produk sebesar 71% dan 29% lainnya dipengaruhi oleh faktor lain. Diketahui bahwa nilai sig. Thitung adalah 3,630. Angka tersebut menunjukkan bahwa thitung > ttabel (3,630 > 1,991) artinya Ha diterima dan Ho ditolak. Sehingga dapat disimpulkan bahwa terdapat pengaruh antara antara sosial media marketing dan kualitas produk terhadap kepuasan pelanggan The Wrappers, Medan.
Chikungunya virus infection in human microglial C20 cells induces mitochondria-mediated apoptosis
Authors: Kumar Narendra , Santhoshkumar Rashmi , Venkataswamy Manjunatha M. 
Published: April 2024

IntroductionChikungunya virus (CHIKV) infection is associated with acute clinical manifestations and chronic joint inflammation. CHIKV has emerged as a significant causative agent of central nervous system (CNS) complications, including encephalitis and related sequelae. Microglial cells, crucial for immune responses and tissue repair in the CNS, play a vital role in the host response to viral infections, with their activation potentially leading to either protection or pathology. In this study, the infection biology of CHIKV in the C20 human microglial cell line was investigated.MethodsThe permissiveness of C20 cells to CHIKV infection was assessed, and viral replication kinetics were compared to Vero E6 cells. Cytopathic effects of CHIKV infection on C20 cells were examined, along with ultrastructural changes using transmission electron microscopy. Additionally, apoptosis induction, mitochondrial membrane potential, and alterations in cell surface marker expression were evaluated by flow cytometry.ResultsCHIKV infection demonstrated permissiveness in C20 cells, similar to Vero cells, resulting in robust viral replication and cytopathic effects. Ultrastructural analysis revealed viral replication, mature virion formation, and distinctive cytoplasmic and nuclear changes in infected C20 cells. CHIKV infection induced significant apoptosis in C20 cells, accompanied by mitochondrial membrane depolarization and altered expression of cell surface markers such as CD11c, CD14, and HLA-DR. Notably, decreased CD14 expression was observed in CHIKV-infected C20 cells.DiscussionThe study findings suggest that CHIKV infection induces apoptosis in C20 microglial cells via the mitochondrial pathway, with significant alterations in cell surface marker expression, particularly CD14 that is linked with apoptosis induction. These observations provide valuable insights into the role of human microglial cells in the host response to CHIKV infection and contribute to the knowledge on the neuropathogenesis of this virus.
Integrating machine learning algorithms and single-cell analysis to identify gut microbiota-related macrophage biomarkers in atherosclerotic plaques
Authors: Ke Yin , Yue Jian , He Jiaming , Liu Guojing 
Published: April 2024

ObjectiveThe relationship between macrophages and the gut microbiota in patients with atherosclerosis remains poorly defined, and effective biological markers are lacking. This study aims to elucidate the interplay between gut microbial communities and macrophages, and to identify biomarkers associated with the destabilization of atherosclerotic plaques. The goal is to enhance our understanding of the underlying molecular pathways and to pave new avenues for diagnostic approaches and therapeutic strategies in the disease.MethodsThis study employed Weighted Gene Co-expression Network Analysis (WGCNA) and differential expression analysis on atherosclerosis datasets to identify macrophage-associated genes and quantify the correlation between these genes and gut microbiota gene sets. The Random Forest algorithm was utilized to pinpoint PLEK, IRF8, BTK, CCR1, and CD68 as gut microbiota-related macrophage genes, and a nomogram was constructed. Based on the top five genes, a Non-negative Matrix Factorization (NMF) algorithm was applied to construct gut microbiota-related macrophage clusters and analyze their potential biological alterations. Subsequent single-cell analyses were conducted to observe the expression patterns of the top five genes and the interactions between immune cells. Finally, the expression profiles of key molecules were validated using clinical samples from atherosclerosis patients.ResultsUtilizing the Random Forest algorithm, we ultimately identified PLEK, IRF8, CD68, CCR1, and BTK as gut microbiota-associated macrophage genes that are upregulated in atherosclerotic plaques. A nomogram based on the expression of these five genes was constructed for use as an auxiliary tool in clinical diagnosis. Single-cell analysis confirmed the specific expression of gut microbiota-associated macrophage genes in macrophages. Clinical samples substantiated the high expression of PLEK in unstable atherosclerotic plaques.ConclusionGut microbiota-associated macrophage genes (PLEK, IRF8, CD68, CCR1, and BTK) may be implicated in the pathogenesis of atherosclerotic plaques and could serve as diagnostic markers to aid patients with atherosclerosis.
The shrinkage behavior of boreholes drilled through deepwater creeping salt formations in West Africa
Authors: Wang Mingchun , Deng Jingen , Li Zhong , Li Mengbo , Xing Zixiao , Zhang Zhe , Yan Chuanliang 
Published: April 2024

Introduction: Salt formations are complex and pose significant risks during oil and gas drilling. Creep behavior in salt formations under geostress can jeopardize drilling safety.Methods: This study analyzes the shrinkage behavior of boreholes drilled through salt formations in West Africa’s Block B, with emphasis on the differential creep rates in two horizontal principal stress directions and the evolution of wellbore shape over time. The impact of drilling fluid density on shrinkage rates is also investigated.Results: After drilling through salt formations, the creep rates differ between the two horizontal principal stress directions. Shrinkage is faster in the direction of minimum horizontal principal stress and slower in the direction of maximum horizontal principal stress. Over time, shrinkage rates converge, resulting in a transition from elliptical to circular wellbore shape. Higher drilling fluid density leads to reduced shrinkage rates.Discussion: These findings contribute to the theoretical guidance for drilling fluid density selection in salt formations.
NLRP6 negatively regulates host defense against polymicrobial sepsis
Authors: Ghimire Laxman , Paudel Sagar , Le John , Jin Liliang , Cai Shanshan , Bhattarai Dinesh , Jeyaseelan Samithamby 
Published: April 2024

IntroductionSepsis remains a major cause of death in Intensive Care Units. Sepsis is a life-threatening multi-organ dysfunction caused by a dysregulated systemic inflammatory response. Pattern recognition receptors, such as TLRs and NLRs contribute to innate immune responses. Upon activation, some NLRs form multimeric protein complexes in the cytoplasm termed “inflammasomes” which induce gasdermin d-mediated pyroptotic cell death and the release of mature forms of IL-1β and IL-18. The NLRP6 inflammasome is documented to be both a positive and a negative regulator of host defense in distinct infectious diseases. However, the role of NLRP6 in polymicrobial sepsis remains elusive.MethodsWe have used NLRP6 KO mice and human septic spleen samples to examine the role of NLRP6 in host defense in sepsis.ResultsNLRP6 KO mice display enhanced survival, reduced bacterial burden in the organs, and reduced cytokine/chemokine production. Co-housed WT and KO mice following sepsis show decreased bacterial burden in the KO mice as observed in singly housed groups. NLRP6 is upregulated in CD3, CD4, and CD8 cells of septic patients and septic mice. The KO mice showed a higher number of CD3, CD4, and CD8 positive T cell subsets and reduced T cell death in the spleen following sepsis. Furthermore, administration of recombinant IL-18, but not IL-1β, elicited excessive inflammation and reversed the survival advantages observed in NLRP6 KO mice.ConclusionThese results unveil NLRP6 as a negative regulator of host defense during sepsis and offer novel insights for the development of new treatment strategies for sepsis.
Metabolomic analysis of rumen-protected branched-chain amino acids in primiparous dairy cows
Authors: Zhao Zhikun , Dong Jianan , Wang Dezhi , Zhao Chen , Tian Xu , Meng Yuan , Zou Yue , Zhao Yang , Qin Guixin , Wang Tao , Sun Zhe , Zhang Xuefeng , Zhen Yuguo 
Published: April 2024

IntroductionPeripartal cows are susceptible to a negative energy balance due to inadequate nutrient intake and high energy requirements for lactation. Improving the energy metabolism of perinatal dairy cows is crucial in increasing production in dairy cows.MethodsIn this study, we investigated the impact of rumen-protected branched-chain amino acid (RPBCAA) on the production performance, energy and lipid metabolism, oxidative stress, and immune function of primiparous dairy cows using metabolomics through a single-factor experiment. Twenty healthy primiparous Holstein cows were selected based on body condition scores and expected calving date, and were randomly divided into RPBCAA (n = 10) and control (n = 10) groups. The control group received a basal diet from calving until 21 d in milk, and the RPBCAA group received the basal diet and 44.6 g/d RPLeu, 25.14 g/d RPIle, and 25.43 g/d RPVal.ResultsIn comparison to the control group, the supplementation of RPBCAA had no significant effect on milk yield and milk composition of the dairy cows. Supplementation with RPBCAA significantly increased the concentrations of insulin, insulin growth factor 1, glucagon, and growth hormones, which are indicators of energy metabolism in postpartum cows. The very low density lipoprotein, fatty acid synthase, acetyl coenzyme A carboxylase, and hormone-sensitive lipase contents of the RPBCAA group were significantly greater than that of the control group; these metrics are related to lipid metabolism. In addition, RPBCAA supplementation significantly increased serum glutathione peroxidase and immunoglobulin G concentrations and decreased malondialdehyde concentrations. Liquid chromatography–mass spectrometry (LC-MS) analysis revealed 414 serum and 430 milk metabolic features. Supplementation with RPBCAA primarily increased concentrations of amino acid and lipid metabolism pathways and upregulated the abundance of serotonin, glutamine, and phosphatidylcholines.DiscussionIn summary, adding RPBCAA to the daily ration can influence endocrine function and improve energy metabolism, regulate amino acid and lipid metabolism, mitigate oxidative stress and maintain immune function on primiparous cows in early lactation.
Advances in filarial hydrocelectomy reporting in Uganda and Nigeria
Authors: D’Souza Susan F. , Awio John P. , Albarka Jehoshaphat , Bougma Windtaré Roland , Bartlett Sarah , Nwosu Christian , Ngom Babacar , Wani Anthony , Gwom Anita , Okello Moses , Aba Abraham , Irema Sarah , Imhansoloeva Martins , Nurudeen Dauda , Wamboga Charles , Debam Mark T. , Zainab Haruna , Aleiro Attahiru , Salah Malam H. , Downs Philip 
Published: April 2024

IntroductionSurgery for hydrocele is part of the WHO recommended essential package of care for people affected by Lymphatic filariasis (LF). In Uganda and Nigeria, LF programme support for hydrocele surgery began in 2017. In 2021 the two programmes adopted a newly developed smartphone-based application to monitor hydrocele surgery and outcome. The application, referred to as the Hydrocele Tracker, gathers information on surgical registration, preoperative information, intraoperative information, postoperative information and follow-up evaluations. It was developed to improve supervision, understand surgical outcomes and reasons for complications, improve reporting and improve data quality for Ministries of Health with active LF programmes.MethodsHydrocele patient information was collected between October 2021 and May 2023 in Uganda (Lango sub-region, 9 districts) and March 2021 - September 2022 in Nigeria (Benue, Kaduna, Kebbi, Sokoto and Kogi States). Additionally patient feedback surveys were undertaken to elicit patient experience and satisfaction with the hydrocele surgery.ResultsPatient data from 2,911 records in the Hydrocele Tracker are presented.DiscussionThe discussion highlights the implications of the data for LF programming, the value of digitisation and approaches to address data quality.
Modeling the consequences of an L1 grammar for L2 production: simulations, variation, and predictions
Authors: Zhang Sijia , Tessier Anne-Michelle 
Published: April 2024

IntroductionThis paper presents a constraint-based grammar of Mandarin low vowel + nasal coda (loVN) sequences first as acquired by L1 learners, and then as transferred to L2 English.MethodsWe simulate phonological learning in Harmonic Grammar using a gradual, error-driven GLA learner, drawing on evidence from L1 Mandarin speakers' perceptual data to support our initial state assumptions. We then compare our simulation results with L2 English production (both anecdotal and ultrasound data), as well as evidence from Mandarin loanword phonology.ResultsOur results align with multiple patterns in the previous empirical literature, including an asymmetry among surface repairs for VN sequences, and we show how these emerge from our assumptions about both the L1 Mandarin grammar and the grammar's evaluation method (i.e., weighted constraints).DiscussionWe discuss the extent to which these results derive from our somewhat novel analysis of place contrasts in L1 Mandarin, and the variability in loVN outputs that we encode directly into the L1 grammar, which are then transferred to the L2 context. Ultimately we discuss how this type of modeling can make falsifiable predictions about phonological development, in both L1 and L2 contexts.
Body composition and metabolic consequences of antibiotics most frequently administered to newborns in intensive care units: an experimental study in healthy newborn rats
Authors: Segura-Cervantes Enrique , Mancilla-Ramírez Javier , Fernández-Urrutia Liliana , González-Gallardo Susana , Mendoza-Gertrudis Lourdes , Valencia-Santaella Jasibe , Galindo-Sevilla Norma 
Published: April 2024

IntroductionThe increasing overuse of antibiotics in recent years has led to antibiotics being the most prescribed drugs for pediatric patients, and 72% of patients in the neonatal intensive care unit are treated with antibiotics. One effect of antibiotic use is the alteration of the microbiota, which is associated with metabolic disorders, including obesity.MethodsThis experimental study in newborn rats compared the administration of ampicillin/meropenem (Access/Watch groups) at 100/10 μg/g every 12 h, cefotaxime 200 μg/g every 24 h (Watch group), and amikacin 15 μg/g every 24 h (Access group) versus saline solution as the control. Each antibiotic was adjusted to the required dosages based on weight, and the doses were administered intraperitoneally daily for 5 days to 10–14 newborn male rats per group. A comparison of the morphometric and biochemical parameters registered on day 28 was performed using ANOVA.ResultsAmikacin had the largest effect on morphometric measurements, and low-density lipoprotein cholesterol, while cefotaxime had the largest effect on glucose and triglycerides, whereas ampicillin/meropenem produced the weakest effect on the measured parameters.DiscussionThe administration of antibiotics in the neonatal stage can affect the body composition of rats as well as the lipid and carbohydrate serum levels. Future studies should evaluate the toxicity of antibiotics in immature neonatal organs and could help to improve therapeutic decisions and prevent the unjustified use of antibiotics in newborns, thereby reducing metabolic consequences.