bluuebunny/crossref_metadata_2025_split huggingface dataset:
Preference of low vision devices in patients with central field loss and peripheral field loss
Authors: Gopalakrishnan Sarika , Paramasivan Gaurav , Sathyaprasath Mathangi , Raman Rajiv 
Published: May 2024

PURPOSE:
The objective of this study was to estimate the profile of patients visiting low vision care clinic at a tertiary eye care center in India and to analyze the preference of low vision devices (LVD).

METHODS:
A retrospective review was done for 450 patients with low vision who were referred to the LVC clinic from January 2019 to December 2019. The participants were categorized into two groups as central field loss (CFL) and peripheral field loss (PFL). Demographic profile details and low vision device preference were documented.

RESULTS:
Out of 450 patients, 242 (53.8%) were diagnosed to have CFL and 208 (46.2%) had PFL. The median age of the overall patients was 34.5 years. Overall, 323 (71.8%) were men and 127 (28.2%) were women. Cone dystrophy (21.1%) was the major cause of low vision among atrophic changes (54.1%) in CFL, and retinitis pigmentosa (81.2%) was the majority in retina related changes (81.7%) in PFL. Overall, 71.3% of the low vision patients preferred LVD. CFL group (76%) preferred LVD more than PFL group (65.9%). Almost 34% of the patients in both CFL and PFL group have preferred half eyes and Ashperics, followed by 32.5% in CFL and 28.1% in PFL preferred dome magnifiers. Statistically significant improvement in distance and near vision with the help of LVD was noted.

CONCLUSION:
The use of LVD can help patients with low vision in restoring useful vision, where medical and surgical treatment have no or a limited role.
Adalimumab treatment for chronic recurrent Vogt-Koyanagi-Harada disease with sunset glow fundus
Authors: Takeuchi Masaru , Nakai Shunsaku , Usui Yoshihiko , Namba Kenichi , Suzuki Kayo , Harada Yosuke , Kusuhara Sentaro , Kaburaki Toshikatsu , Tanaka Rie , Takeuchi Masaki , Mizuki Nobuhisa , Nakai Kei , Goto Hiroshi , Herbort Carl P. 
Published: May 2024

PURPOSE:
We investigated the efficacy and safety of adalimumab (ADA) treatment for chronic recurrent Vogt-Koyanagi-Harada (VKH) patients with sunset glow fundus (SGF).

METHODS:
Medical records of 50 chronic recurrent VKH patients with SGF who received ADA treatment for more than 6 months were retrospectively reviewed.

RESULTS:
The mean age of chronic recurrent VKH patients with SGF was 55.9 ± 14.4 years, and the male/female ratio was 26/24. Before ADA treatment, the mean daily dose of systemic corticosteroids was 16.5 ± 12.7 mg, and 22 patients (44%) were under immunosuppressors. LogMAR visual acuity (VA), flare counts, subfoveal choroidal thickness (SFCT), indocyanine green angiography scores, and corticosteroid and cyclosporine doses were significantly reduced by ADA treatment at 6 months compared to baseline. Among all parameters, flare count was significantly related to LogMAR VA. LogMAR VA was significantly related to flare counts but not to SFCT nor to ICGA scores. ADA treatment was continued in 94%.

CONCLUSION:
ADA was shown to be effective in achieving remission of chronic recurrent VKH disease with SGF refractory to conventional treatments, and was generally well tolerated with few serious adverse events.
Early lens aspiration with posterior chamber intraocular lens and capsular tension ring in microspherophakia to avoid lens-induced complications
Authors: Al-Rajhi Ali A. , Almazyad Enmar M. 
Published: May 2024

PURPOSE:
To report the surgical outcome of early lens aspiration, posterior chamber intraocular lens (PC IOL), and capsular tension ring (CTR) in a case series of microspherophakia (MSP) and secondary glaucoma.

METHODS:
Case series of 18 eyes of MSP cases presented with lenticular myopia and secondary glaucoma that underwent early lens aspiration, PC IOL and CTR by one ophthalmologist. Baseline, long-term postoperative outcomes and complications were documented.

RESULTS:
All cases underwent successful surgery with lens aspiration PC IOL implantation and CTR insertion without intraoperative complications. One of the 18 cases was a delayed referral which had broad anterior synechiae and following lens aspiration developed corneal decompensation. In one eye, CTR implantation was not possible hence, lens aspiration with scleral fixation (SF) of 3 piece IOL was performed (excluded from the analysis). Overall there was an improvement in visual acuity (from 0.3 ± 0.1 to 0.2 ± 0.2 LogMar, P = 0.006), intraocular pressure (IOP), and most notably, deepening of the anterior chamber. Some cases required subsequent glaucoma surgery to control IOP. After a long duration of follow-up, all cases had stable capsular lens complex and no capsular phimosis.

CONCLUSION:
Early Lens aspiration with CTR and PCIOL alone in MSP with lens subluxation has a significant impact on the patient's quality of vision, deepening the anterior chamber and preventing complications or poor outcomes. In addition, good capsular-lens complex stability and absence of capsular phimosis or phacodonesis on long-term follow-up were obtained.
Combined corneal wavefront-guided transepithelial photorefractive keratectomy and accelerated corneal collagen cross-linking following intracorneal ring segment implantation in management of moderate keratoconus
Authors: Bakhsh Ashraf M. , Elwan Shaaban A. M. , El-Atris Tamer M. , Al-Salowle Abdulrahman M. , Alsamnan Mazen S. 
Published: May 2024

PURPOSE:Keratoconus (KC) leads to gradual progressive loss of vision in young and adult patients. For the purpose of visual rehabilitation and for hindering KC progression in patients, we designed this study. The main aim of this study is to help the KC patients to improve and stabilize their vision.METHODS:This prospective consecutive uncontrolled study includes 36 eyes of 36 patients with moderate degree of KC. All patients underwent combined wavefront-guided transepithelial photorefractive keratectomy (TPRK) and accelerated corneal collagen cross-linking (ACXL) after intracorneal ring segment (ICRS) implantation. Different measures will be evaluated at baseline, after ICRS implantation, and at one, 3, 6, and 12 months after combined (TPRK and ACXL). These measurements are uncorrected distance visual acuity (UDVA), corrected distance visual acuity (CDVA), manifest refraction spherical equivalent (MRSE), corneal indices based on Scheimpflug tomography, and higher-order aberrations (HOAs) based on (Sirius, Schwind) tomography.RESULTS:There were significant improvements in logMAR (UDVA and CDVA) and reduction in sphere, manifest cylinder, MRSE, maximal keratometry, and mean keratometry after ICRS implantation in the first stage. After TPRK and ACXL as the second stage, there were significant improvements in visual acuity of both logMAR UDVA and CDVA. Reduction in refractive outcomes, including MRSE, sphere, and manifest cylinder. All corneal indices including steep, flat, mean, and maximal keratometries had been decreased. Furthermore, there were significant improvements in the final root mean square, HOAs, and coma aberrations from baseline.CONCLUSION:In moderate KC, triple therapy of ICRS implantation followed by combined TPRK and ACXL appears to be a safe and effective approach. This approach provides an improvement in visual acuity, refraction, corneal indices, and HOAs. These improvements were maintained for 1 year postoperatively. It also halts KC progression.
Prognostic nutritional index as a novel marker for diabetic retinopathy in individuals with type 2 diabetes mellitus
Authors: Kurtul Bengi E. , Koca Suleyman , Yilmaz Muge O. 
Published: May 2024

PURPOSE:
In recent years, the prognostic nutritional index (PNI), an easily obtainable nutritional inflammatory marker, has been introduced as an independent prognostic indicator for various types of cancers and cardiovascular diseases. However, its clinical importance in the area of ophthalmology is not well known yet. We aimed to elucidate the association between the PNI and the occurrence of diabetic retinopathy (DR) in patients with type 2 diabetes mellitus (T2DM).

METHODS:
In this cross-sectional study, the PNI was applied to 128 consecutive patients with T2DM. The relationship between the PNI and the occurrence of DR was examined. PNI was calculated as 10× (serum albumin) + 0.005 × (total lymphocyte count). The risk factors for DR were evaluated using multivariate logistic regression analysis. A receiver operating characteristic (ROC) curve analysis of PNI for predicting DR was performed.

RESULTS:
Patients with DR had significantly lower levels of PNI than those without DR (41.20 ± 4.81 and 44.49 ± 3.10, respectively,P< 0.001). Multivariate regression analysis indicated that PNI, together with the duration of diabetes and creatinine, was an independent factor for DR occurrence (odds ratio, 0.885; 95% confidence interval: 0.735–0.971;P= 0.017). ROC curve analysis revealed that the best cutoff value of PNI was 43 (area under the curve: 0.713; sensitivity: 74%; specificity: 64%).

CONCLUSION:
A lower PNI value is common among T2DM patients with DR and is strongly associated with the occurrence of DR. The PNI might be a useful biomarker for identifying DR to improve the risk stratification and management of T2DM patients.
Predictors of limited early response to anti-vascular endothelial growth factor therapy in neovascular age-related macular degeneration with machine learning feature importance
Authors: Perkins Scott W. , Wu Anna K. , Singh Rishi P. 
Published: May 2024

PURPOSE:
Patients with neovascular age-related macular degeneration (nAMD) have varying responses to anti-vascular endothelial growth factor injections. Limited early response (LER) after three monthly loading doses is associated with poor long-term vision outcomes. This study predicts LER in nAMD and uses feature importance analysis to explain how baseline variables influence predicted LER risk.

METHODS:
Baseline age, best visual acuity (BVA), central subfield thickness (CST), and baseline and 3 months intraretinal fluid (IRF) and subretinal fluid (SRF) for 286 eyes were collected in a retrospective clinical chart review. At month 3, LER was defined as the presence of fluid, while early response (ER) was the absence thereof. Decision tree classification and feature importance methods determined the influence of baseline age, BVA, CST, IRF, and SRF, on predicted LER risk.

RESULTS:
One hundred and sixty-seven eyes were LERs and 119 were ERs. The algorithm achieved area under the curve = 0.66 in predicting LER. Baseline SRF was most important for predicting LER while age, BVA, CST, and IRF were somewhat less important. Nonlinear trends were observed between baseline variables and predicted LER risk. Zones of increased predicted LER risk were identified, including age <74 years, and CST <290 or >350 μm, IRF >750 nL, and SRF >150 nL.

CONCLUSION:
These findings explain baseline variable importance for predicting LER and show SRF to be the most important. The nonlinear impact of baseline variables on predicted risk is shown, increasing understanding of LER and aiding clinicians in assessing personalized LER risk.
Genome assembly of the rare and endangered Grantham’s camellia, Camellia granthamiana
Authors:   Hong Kong Biodiversity Genomics Consortium, Hui Jerome H. L. , Chan Ting Fung , Chan Leo Lai , Cheung Siu Gin , Cheang Chi Chiu , Fang James Kar-Hei , Gaitan-Espitia Juan Diego , Lau Stanley Chun Kwan , Sung Yik Hei , Wong Chris Kong Chu , Yip Kevin Yuk-Lap , Wei Yingying , Law Sean Tsz Sum , So Wai Lok , Nong Wenyan , Lau David Tai Wai , Yip Ho Yin 
Published: May 2024

Grantham’s camellia (Camellia granthamiana Sealy) is a rare and endangered tea species discovered in Hong Kong in 1955 and endemic to southern China. Despite its high conservation value, the genomic resources of C. granthamiana are limited. Here, we present a chromosome-scale draft genome of the tetraploid C. granthamiana (2n = 4x = 60), combining PacBio long-read sequencing and Omni-C data. The assembled genome size is ∼2.4 Gb, with most sequences anchored to 15 pseudochromosomes resembling a monoploid genome. The genome has high contiguity, with a scaffold N50 of 139.7 Mb, and high completeness (97.8% BUSCO score). Our gene model prediction resulted in 68,032 protein-coding genes (BUSCO score of 90.9%). We annotated 1.65 Gb of repeat content (68.48% of the genome). Our Grantham’s camellia genome assembly is a valuable resource for investigating Grantham’s camellia’s biology, ecology, and phylogenomic relationships with other Camellia species, and provides a foundation for further conservation measures.
ENHANCING NEGOTIATION SKILLS WITHIN EDUCATIONAL SETTING
Authors: Karapetyan Anna 
Published: May 2024

The study of negotiation skills within education extends beyond verbal communication to encompass cultural competence. Language instruction not only facilitates language acquisition but also fosters development of negotiation skills. Thus, the focus of the present study is on integrating negotiation skills training within the framework of English language instruction, in higher education in particular. The investigation carried out with the application of qualitative and quantitative research methodology, investigates the role of negotiation in educational contexts, discusses the significance of integrating negotiation skills training into higher education, evaluates the effectiveness of various teaching methods in enhancing students’ negotiation abilities, examines the relationship between negotiation and language acquisition. As a result, it can be stated that the integration of negotiation training into the education classroom holds immense potential for students (both academically and personally) in today’s globalized world, thus representing not only an educational imperative but also a societal necessity enabling students to navigate confidently in today’s increasingly complex and interconnected world.
Հայաստանի Հանրապետության հարաբերությունները Համաձայնության պետությունների (Անտանտ) և Ամերիկայի Միացյալ Նահանգների հետ (1919 փետրվար-1920 հունվար)
Authors: Պետրոսյան Գեղամ 
Published: May 2024

Հոդվածում համակողմանիորեն ներկայացվում և ամբողջացվում են այն հիմնական պատճառները, թե ինչու Հայաստանի Հանրապետությունն իր գոյության առաջին փուլում (1918 թթ. հունիս-նոյեմբեր) չէր կարող ինքնուրույն և ազատ արտաքին քաղաքականություն վարել և դիվանագիտական հարաբերություններ հաստատել Համաձայնության դաշինքի՝ Անտանտի մեծ դաշնակիցների և դաշինքին հարող պետությունների հետ:
Առաջին աշխարհամարտում օսմանյան Թուրքիայի և նրա դաշնակիցների վերջնական պարտությամբ ստեղծված աշխարհաքաղաքական բարենպաստ նոր իրադրությունում Հայաստանի Հանրապետությունն այլևս ազատ էր տնօրինելու իր արտաքին քաղաքականությունը և կարող էր դիվանագիտական ավելի ակտիվ հարաբերություններ հաստատելու ջանքեր գործադրել Անտանտի՝ Ամերիկայի Միացյալ Նահանգների, Ֆրանսիայի, Անգլիայի և Հայաստանի Հանրապետության համար ավելի քան կենսական և անվտանգային նշանակություն ունեցող Ռուսաստանի խորհրդային և ոչ խորհրդային (հակաբոլշևիկյան) պետական կազմավորումների և այլ պետությունների հետ:
Քննության է առնվում քաղաքական նոր պայմաններում Հայաստանի Հանրապետության արտաքին քաղաքականության առաջնային խնդիրներից մեկը՝ հարաբերությունների հաստատումը Ամերիկայի Միացյալ Նահանգների հետ: Բացահայտվում և ցույց են տրվում նաև այդ հարաբերությունների հաստատման քաղաքական, դիվանագիտական, տեխնիկական բազմաթիվ ու բազմաբնույթ դժվարությունները և խոչընդոտները:
Indium-111 radiolabelling of a brain-penetrant Aβ antibody for SPECT imaging
Authors: Gustavsson Tobias , Herth Matthias M. , Sehlin Dag , Syvänen Stina 
Published: May 2024

Background: The development of bispecific antibodies that can traverse the blood–brain barrier has paved the way for brain-directed immunotherapy and when radiolabelled, immunoPET imaging. The objective of this study was to investigate how indium-111 (111In) radiolabelling with compatible chelators affects the brain delivery and peripheral biodistribution of the bispecific antibody RmAb158-scFv8D3, which binds to amyloid-beta (Aβ) and the transferrin receptor (TfR), in Aβ pathology-expressing tg-ArcSwe mice and aged-matched wild-type control mice.
Methods: Bispecific RmAb158-scFv8D3 (biAb) was radiolabelled with 111In using CHX-A”-DTPA, DOTA, or DOTA-tetrazine (DOTA-Tz). Affinity toward TfR and Aβ, as well as stability, was investigated in vitro. Mice were then intravenously administered with the three different radiolabelled biAb variants, and blood samples were collected for monitoring pharmacokinetics. Brain concentration was quantified after 2 and 72 h, and organ-specific retention was measured at 72 h by gamma counting. A subset of mice also underwent whole-body Single-photon emission computed tomography (SPECT) scanning at 72 h after injection. Following post-mortem isolation, the brains of tg-ArcSwe and WT mice were sectioned, and the spatial distribution of biAb was further investigated with autoradiography.
Results: All three [111In]biAb variants displayed similar blood pharmacokinetics and brain uptake at 2 h after administration. Radiolabelling did not compromise affinity, and all variants showed good stability, especially the DOTA-Tz variant. Whole-body SPECT scanning indicated high liver, spleen, and bone accumulation of all [111In]biAb variants. Subsequent ex vivo measurement of organ retention confirmed SPECT data, with retention in the spleen, liver, and bone – with very high bone marrow retention. Ex vivo gamma measurement of brain tissue, isolated at 72 h post-injection, and ex vivo autoradiography showed that WT mice, despite the absence of Aβ, exhibited comparable brain concentrations of [111In]biAb as those found in the tg-ArcSwe brain.
Conclusions: The successful 111In-labelling of biAb with retained binding to TfR and Aβ, and retained ability to enter the brain, demonstrated that 111In can be used to generate radioligands for brain imaging. A high degree of [111In]biAb in bone marrow and intracellular accumulation in brain tissue indicated some off-target interactions or potential interaction with intrabrain TfR resulting in a relatively high non-specific background signal.
Pengembangan Media Pembelajaran Digital Interaktif Pada Mata Pelajaran IPS di Sekolah Dasar
Authors: S Nur Intan Permata , Idawati Idawati , Nawir Muhammad 
Published: May 2024

Penelitian ini merupakan penelitian pengembangan dengan menggunakan model ASSURE yang bertujuan untuk menghasilkan produk berupa media pembelajaran digital interaktif pada mata pelajaran IPS kelas IV UPTD SDN 14 Samanggi Kabupaten Maros, ditinjau dari proses pengembangan, kelayakan, kepraktisan dan keefektifan. Model pengembangan ASSURE yang digunakan merupakan rancangan oleh Sharon E. Smaldino, Robert Heinich, Michael Molenda, dan James D. Russell, yang meliputi tahapan: Analyze Learner; State Objectives; Select or Design Media, and Materials; Utilize Media and Materials; Require Learner Parcipation; Evaluate. Instrumen yang digunakan adalah lembar validasi ahli media dan ahli materi, angket respon guru, lembar observasi keterlaksanaan media, tes hasil belajar, angket sikap peserta didik, lembar observasi sikap, serta dokumentasi. Hasil penelitian: (1) uji kelayakan berdasarkan ahli media memperoleh skor 91,5% dan ahli materi memperoleh skor 96,5%, termasuk dalam kategori sangat layak; (2) uji kepraktisan berdasarkan observasi keterlaksanaan media dan respon guru memperoleh skor 92,5% dan 10%, termasuk dalam kategori sangat praktis (3) uji keefektifan, berdasarkan tes hasil belajar peserta didik uji kelompok kecil sebanyak 76% memperoleh kategori hasil belajar sangat tinggi , 19% memperoleh kategori hasil belajar tinggi dan 5% kategori sedang. Kemudian, uji kelompok besar sebanyak 88% berada pada kategori hasil belajar sangat tinggi dan 12% berada pada kategori hasil belajar tinggi. Berdasarkan angket sikap, peserta didik memperoleh 93% sikap sangat baik serta 7% memiliki sikap baik dalam menggunakan media pembelajaran digital interaktif. Selanjutnya berdasarkan observasi sikap peserta didik memperoleh skor 94% dan 100% dengan kategori sangat baik. secara keseluruhan termasuk kedalam kategori sangat efektif. Maka, adanya produk ini memudahkan peserta didik dalam pendalaman materi pembelajaran sehingga berpengaruh terhadap hasil belajar siswa. Dengan adanya penelitian ini diharapkan dapat memberikan kontribusi positif dalam dunia pendidikan dan dapat menjadi referensi bagi peneliti selanjutnya
Aspek Manajemen Dan Kepatuhan Prinsip Syariah Dalam Penilaian Kesehatan BMT Usaha Gabungan Terpadu (UGT) Sidogiri Pasuruan
Authors: Rahajeng Yekti 
Published: May 2024

Penelitian ini bertujuan untuk menganalisis tingkat kesehatan BMT UGT Sidogiri dilihat dari aspek manajemen dan kepatuhan prinsip syariah. Metode penelitian yang digunakan dalam penelitian ini dilakukan secara statistik deskriptif. Hasil penelitian ini mengatakan bahwa pelaksanaan manajemen dan kepatuhan prinsip syariah di BMT UGT Sidogiri pada tahun 2023 tergolong baik dan patuh. Khusus pada manajemen permodalan masih terdapat kelemahan tapi masih dalam kondisi aman. Kelemahan tersebut terletak pada tingkat pertumbuhan modal sendiri lebih kecil dari tingkat pertumbuhan aset dan tingkat pertumbuhan modal sendiri yang berasal dari anggota kurang dari 10 % dibandingkan tahun sebelumnya. Walaupun begitu secara garis besar BMT UGT Sidogiri pada tahun 2023 sudah menjalankan Good Coorporate Governance dan termasuk lembaga keuangan yang patuh pada prinsip syariah.
Kata kunci : Baitul Maal wat Tamwil, penilaian kesehatan, manajemen, kepatuhan prinsip syariah.
From God to Orphan: The Deep Humanity and Deep Ecology of Limba Palm Wine Practice
Authors: Paracka Jr. Daniel J. , Vaught Seneca D. 
Published: May 2024

Abstract
This article’s research situates the local values, livelihoods, and stories of Limba palm wine practice within a discourse of ecospirituality and environmental sustainability using interdisciplinary methods to integrate perspectives from diverse fields including religious studies, peace studies, and Africana studies. Our longitudinal analysis incorporates field research conducted among the Limba of Sierra Leone between 1961 to the present by multiple researchers, providing an in-depth examination of palm wine traditions contextualized across a range of West African communities. The authors assert that Limba palm wine tapping has helped sustain important values and ways of life throughout a turbulent history encompassing periodic episodes of ethnic conflict, structural and traumatic violence, and environmental instability. Thus, Limba palm wine culture demonstrates how Indigenous knowledge, honored traditions, and sacred rituals empower spiritual and ecological worldviews that speak directly to processes of reparative reconciliation and resiliency.
Nghiên cứu đánh giá khả năng sử dụng xỉ nhôm chế tạo gạch cho các công trình văn hóa
Authors: Long Hoang , Trần Văn Bình , Nguyễn Thị Thanh Chúc , Đỗ Văn Hùng , Cao Đức Tâm 
Published: May 2024

Hiện nay, nhôm được sản xuất theo hai phương pháp cơ bản: sản xuất trực tiếp từ bauxit và tái chế từ các phế liệu nhôm. Quá trình tái chế nhôm tạo ra xỉ nhôm gây ô nhiễm môi trường. Tuy nhiên chất thải này có hàm lượng oxit nhôm cao có thể trở thành loại nguyên vật liệu tiềm năng để sản xuất các loại vật liệu nung. Bài báo này trình bày kết quả nghiên cứu sử dụng xỉ nhôm để chế tạo gạch định hướng phục vụ các công trình văn hóa. Trong nghiên cứu sử dụng xỉ nhôm với hàm lượng 40÷60%, và tạo hình mẫu gạch theo phương pháp bán khô. Kết quả cho thấy, các sản phẩm gạch có bề mặt khá đẹp, cường độ chịu nén cao khoảng 400kG/cm2, và độ hút nước 10÷12% đạt yêu cầu kỹ thuật theo TCVN 1451:1998. Kết quả nghiên cứu có thể góp phần vào việc giải quyết vấn đề môi trường tại các làng nghề tái chế nhôm ở Việt Nam.