bluuebunny/crossref_metadata_2025_split huggingface dataset:
Spectral Characterization and Antimicrobial Activity of Some Schiff Bases Derived from 4‐Methyl‐2‐aminophenol
Authors: Gürbüz Demet , Cinarli Adem , Tavman Aydin , Birteks?z A. Seher 
Published: April 2012

AbstractA series of N‐(5‐methyl‐2‐hydroxyphenyl)‐(2/3/4/5‐substituted)‐benzaldimines (I–XIII) were synthesized using appropriate synthetic route. Their structures were characterized by FT‐IR, UV‐Visible, ESI‐MS, 1H‐ and 13C‐NMR spectroscopic techniques and analytical methods. The crystal structure of N‐(5‐methyl‐2‐hydroxyphenyl)‐3,4‐dimethoxybenzaldimine (XIII) was determined by X‐ray diffraction at room temperature. Relationship between the melting points and the structures of the compounds were examined. Antibacterial activities of the compounds were evaluated against Staphylococcus aureus, Staphylococcus epidermidis, Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa and Proteus mirabilis. Antifungal activities were reported for Candida albicans. Some of the Schiff bases showed considerable antimicrobial activity against S. aureus and C. albicans.
Liquid Crystalline Behaviours of the Complexes Based on 1,3,4‐Oxadiazole Derivative and Benzoic Acid
Authors: Zhao Chengxiao , Wang Haitao , Ran Xia , Bai Binglian , Zhang Yan , Li Min 
Published: April 2012

AbstractA non‐liquid crystal compound (4‐POXD‐6) containing the 1,3,4‐oxadiazole group and pyridyl (py) group was synthesized. And a series of supramolecular mesogenic complexes were obtained by mixing 4‐POXD‐6 and 4‐alkoxybenzoic acids (Cn, n=6, 8, 12). The liquid crystalline properties of 4‐POXD‐6/Cn (n=6, 8, 12) were investigated by means of differential scanning calorimetry, polarized optical microscopy, and wide‐angle X‐ray diffraction. It was found that 4‐POXD‐6/Cn (6, 8) display monotropic nematic and smectic A phases, while 4‐POXD‐6/C12 exhibits a SmX phase in the heating process and a SmA phase in the cooling run. Variable‐temperature FTIR spectroscopic studies revealed hydrogen bonds existed in both crystalline and liquid crystalline phases.
Dehydrogenation of Propane to Propylene in the Presence of CO2 over Steaming‐treated HZSM‐5 Supported ZnO
Authors: Zhang Fan , Miao Changxi , Yue Yinghong , Hua Weiming , Gao Zi 
Published: April 2012

AbstractDehydrogenation of propane to propylene over zinc oxide catalysts supported on steaming‐treated HZSM‐5 in the presence of CO2 has been investigated. The highest catalytic performance can be achieved on the 5%ZnO/HZSM‐5(650) catalyst with the HZSM‐5 support steaming at 650°C, which allows the maximum propylene yields of 29.7% and 20.3% at the initial and steady states, respectively, in the catalytic dehydrogenation of propane at 600°C. The superior catalytic performance of this catalyst can be attributed to high dispersion of ZnO and appropriate Br?nsted acidity of the HZSM‐5(650) support. The catalytic stability is enhanced by the addition of CO2 to the feed gas due to the suppression of coke formation.
An Improved Method for Synthesizing LiV3O8 Nanorods
Authors: Sun Junli , Zhao Min 
Published: April 2012

AbstractThis paper reports on the synthesis, characterization and electrochemical performance of LiV3O8 nanorods which were prepared through a very facile hydrothermal route. The diameters of the LiV3O8 nanorods are about 150 nm. The morphology of LiV3O8 can be controlled by adjusting the reaction conditions such as the reaction time and temperature. Electrochemical measurements reveal that the as‐prepared LiV3O8 nanorods display high initial discharge capacities (292.5 mA·hg−1) and excellent cyclability. This result indicates that the nanorods are a promising cathode candidate material for lithium batteries.
Microwave Irradiation for Accelerating Synthesis of Diarylimidizo[1,5‐a]pyrimidine Based on Isoflavones
Authors: Zhang Zunting , Zhang Pengfei , Kang Taoying , Zhu Mulin 
Published: April 2012

AbstractMicrowave irradiation was used to accelerate the cyclocondensation of isoflavones and 5‐amino‐1H‐imidazole‐4‐carboxamide in the presence of sodium hydroxide to produce 3,4‐diphenyl‐imidazo[1,5‐a]pyrimidines in good to moderate yields.
A Sustainable Synthesis of 2‐Benzoxazyl and 2‐Benzothiazyl Ketones from Alkynyl Bromides and 2‐Amino(thio)phenols Promoted by a Recyclable Catalytic System
Authors: Cui Liangyan , He Yan , Fan Xuesen 
Published: April 2012

AbstractAn environmentally and economically sustainable synthesis of 2‐benzoxazyl ketones and 2‐benzothiazyl ketones through FeCl3·6H2O catalyzed tandem reactions of alkynyl bromides with 2‐amino(thio)phenols in [bmim]BF4 has been developed. Remarkable advantages of this new synthetic strategy include high efficiency, readily available starting materials, and recyclable catalyst and reaction medium.
An Efficient Palladium and Bis(2‐pyridylmethyl)amine‐based System for Suzuki‐Miyaura Cross‐Coupling under Aqueous and Aerobic Condition
Authors: Yu Jianjun , Wang Limin , Liu Mingtao , Qiu Jun , Shen Qiang , Fang Lei , Tang Jun 
Published: April 2012

AbstractA novel PdCl2/bis(2‐pyridylmethyl)amine‐based ligand (1) catalytic system, which is water‐soluble and air‐stable, has been successfully synthesized and applied for Suzuki‐Miyaura cross‐coupling reaction. In the presence of catalytic amount of PdCl2/1 system, arylboronic acids can couple with a wide range of aryl halides, including aryl bromides and aryl chlorides. The reactions proceed under mild conditions to give excellent yields, and a wide range of functionalities is tolerated.
Synthesis, Crystal Structures and Electrochemical Properties of Complexes [M(ImH)4(tfbdc)(H2O)] (M=Co, Ni)
Authors: Wu Yujuan , Yu Lili , Cheng Meiling , Han Wei , Wang Lidong , Guo Xue , Liu Qi 
Published: April 2012

AbstractThe title complexes [M(ImH)4(tfbdc)(H2O)] (1: M=Co; 2: M=Ni) (ImH=imidazole, tfbdc=2,3,5,6‐tetrafluoroterephthalate) were synthesized by the reaction of M(OAc)2·4H2O, H2tfbdc and ImH in water solution. The complexes were characterized by elemental analysis, IR spectra, thermogravimetric analysis, cyclic voltammetry and X‐ray single crystal structure analysis. Structural analysis reveals that 1 and 2 possess isostructure: monoclinic, P21/c, Z=4. M(II) ion in complexes 1 and 2 has a distorted octahedral geometry coordinated by one oxygen atom from water, one oxygen atom from tfbdc2− and four nitrogen atoms from ImHs. They are discrete zero‐dimensional molecular complexes. And the adjacent monomeric components are connected by hydrogen bonds to form a supramolecule. Electrochemical properties of the complexes 1 and 2 show that electron transfer of M(II) between M(III) in electrolysis is a quasi‐reversible process.
Microwave‐assisted Ionothermal Synthesis and Characterization of Zeolitic Imidazolate Framework‐8
Authors: Yang Lisha , Lu Huimin 
Published: April 2012

AbstractThe zeolitic imidazolate framework‐8 (ZIF‐8) was successfully synthesized using ionic liquids as structure‐directing agent under microwave irradiation. Ionic liquids are green solvents with low vapour pressure and good thermal stability. They are appropriate templates for microporous materials and ideal microwave absorbers. The microwave‐assisted ionothermal synthesis applied in this paper was expected to be a promising method for the preparation of microporous materials. Results showed that the as‐synthesized samples (300–500 nm in diameter) could be synthesized in a short time (60 min) and possessed regular morphology, stable structure and high thermal stability (up to 720°C in argon atmosphere). Nitrogen adsorption‐desorption test illustrated that samples produced by microwave heating had a higher surface area. Carbon dioxide adsorption test indicated that the samples synthesized by microwave heating had better carbon dioxide adsorption ability than those by conventional heating.
A Novel Protocol for the Regioselective Bromination of Primary Alcohols in Unprotected Carbohydrates or Glycosides
Authors: Xue Weihua , Zhang Lifen 
Published: April 2012

AbstractThe regioselective and efficient bromination of primary hydroxyl groups in unprotected carbohydrates or glycosides is successfully achieved by using (chloro‐phenylthio‐methylene)dimethylammoniumchloride (CPMA) in the presence of tetrabutylammonium bromide (TBAB) in dry DMF.
Competitiveness as a Strategic Outcome of Corporate Social Responsibility
Authors: Marín Longinos , Rubio Alicia , de Maya Salvador Ruiz 
Published: April 2012

ABSTRACTThere is a gap in the literature concerning the effects of corporate social responsibility (CSR) on corporate strategy. This study analyses the influence of CSR on competitiveness as a strategic dimension of companies. It addresses the conditions under which CSR has a positive influence on competitiveness through testing the moderator effect of corporate strategy, size, and industry. Based on an empirical study of 144 companies, the results show a positive effect of CSR on competitiveness, which is stronger for large companies and for companies that follow a proactive (vs reactive) strategy, while no differences appear between service and manufacturing industries. Copyright © 2012 John Wiley & Sons, Ltd and ERP Environment.
The impact of effective continuous positive airway pressure on homeostasis model assessment insulin resistance in non‐diabetic patients with moderate to severe obstructive sleep apnea
Authors: Yang Dan , Liu Zhihong , Yang Haixing 
Published: April 2012

SummaryPrevious studies on the effects of continuous positive airway pressure (CPAP) on homeostasis model assessment insulin resistance (HOMA‐IR) in obstructive sleep apnea patients have yielded conflicting results. Therefore, we conducted this meta‐analysis to evaluate the impact of effective CPAP on HOMA‐IR in non‐diabetic patients with moderate to severe obstructive sleep apnea. We searched PubMed, HighWire Press, Ovid Medline (R), Cochrane library and EMBASE before December 2011 on original English language studies. The data on HOMA‐IR and body mass index (BMI) were extracted from these studies. As compared with baseline values, 8 to 24 weeks of effective CPAP (>4 h/night) treatment significantly reduced HOMA‐IR by an average of 0.75(95% CI, from −0.96 to −0.53; p < 0.001). However, in subjects with irregular CPAP (<4 h/night), this effect was not observed (−0.22; 95%CI, from −2.24 to 1.80; p = 0.83). There were no intervention‐related changes in BMI in both regular and irregular CPAP. Our analysis showed that 8 to 24 weeks of effective CPAP could significantly improve HOMA‐IR in non‐diabetic patients with moderate to severe obstructive sleep apnea, while no significant changes in BMI were detected. Further large scale, randomized and controlled trials are needed to evaluate the longer treatment and its possible effects on weight control and cardiovascular disease. Copyright © 2012 John Wiley & Sons, Ltd.
Obesity is associated with activated and insulin resistant immune cells
Authors: Viardot A. , Heilbronn L. K. , Samocha‐Bonet D. , Mackay F. , Campbell L. V. , Samaras K. 
Published: April 2012

AbstractBackgroundObesity and type 2 diabetes mellitus are characterized by insulin resistance and ‘low‐grade inflammation’; however, the pathophysiological link is poorly understood. To determine the relative contribution of obesity and insulin resistance to systemic ‘inflammation’, this study comprehensively characterized circulating immune cells in different grades of obesity.MethodsImmune cell phenotypes and activation status were analysed by flow cytometry cross‐sectionally in morbidly obese (n = 16, body mass index (BMI) 42.2 ± 5.4 kg/m2), overweight (n = 13, BMI 27.4 ± 1.6 kg/m2) and normal weight (n = 12, BMI 22.5 ± 1.9 kg/m2) subjects.ResultsObese, but not overweight subjects, had increased activation marker expression on neutrophils, monocytes, T‐lymphocytes and polarization of T helper cells towards a pro‐inflammatory type 1‐phenotype (Th1). Th1 numbers correlated positively with the degree of insulin resistance (homeostasis model assessment, p < 0.05). Lymphocytes from obese subjects showed reduced insulin‐stimulated AKT‐phosphorylation in vitro. Supra‐physiological insulin concentrations did not affect T‐cell differentiation, which under normal circumstances would promote an anti‐inflammatory T helper type 2‐phenotype.ConclusionsThese results show that morbid obesity is characterized by circulating immune cells that are activated and insulin resistant, with the T‐cell balance polarized towards a pro‐inflammatory Th1 phenotype. The loss of insulin‐induced suppression of inflammatory phenotypes in circulating immune cells could contribute to the systemic and adipose tissue inflammation found in morbid obesity. Copyright © 2012 John Wiley & Sons, Ltd.
Birth weight in newborn infants with different diabetes‐associated HLA genotypes in three neighbouring countries: Finland, Estonia and Russian Karelia
Authors: Peet Aleksandr , Kool Pille , Ilonen Jorma , Knip Mikael , Tillmann Vallo ,   for the DIABIMMUNE Study Group
Published: April 2012

AbstractBackgroundHuman leukocyte antigen (HLA) genotypes associated with increased risk for type 1 diabetes mellitus (T1D) have been reported to be associated with increased birth weight. We set out to investigate the association between HLA haplotypes conferring risk for T1D and birth weight and search for possible differences in the strength of these associations among populations with contrasting incidence of T1D.MethodsAs a part of the EU‐funded DIABIMMUNE study, genotyping for the HLA haplotypes associated with T1D was performed in 8369 newborn infants from Estonia, Finland and Russian Karelia. Infants born before 35 gestational weeks, from mothers with diabetes, and multiple pregnancies were excluded. Relative birth weight, expressed in standard deviation scores, was estimated for each gestational week, sex and country. The standard deviation scores were calculated internally using the actual population studied. According to their HLA haplotypes, participants were divided into risk groups, and the distribution of birth weight between quartiles was analysed.ResultsWe did not find any direct association between various HLA risk‐associated genotypes (HLA DR3‐DQ2/DR4‐DQ8, DR3‐DQ2/X or DR4‐DQ8/X) and birth weight. We observed a significant relationship between increased relative birth weight and the protective HLA‐DR2‐DQ6 and DR13‐DQ6 haplotypes. This association was significant only when these haplotypes were found together with the DR4‐DQ8 haplotype.ConclusionsThe previously reported association between HLA‐risk haplotypes for T1D and an increased birth weight was not confirmed. This suggests that the mechanisms behind the association between high birth weight and risk for T1D may be not directly HLA related. Copyright © 2012 John Wiley & Sons, Ltd.
Enrichment of edible oil with sea buckthorn by‐products using ultrasound‐assisted extraction
Authors: Chemat Farid , Périno‐Issartier Sandrine , Loucif Lynda , Elmaataoui Mohamed , Mason Timothy J. 
Published: April 2012

AbstractSea buckthorn (SBT) pomace, a by‐product of juice production, has been studied as a potential carotenoids source because such compounds are of great interest in the food industry. Ultrasound‐assisted extraction (UAE) has been used to improve the direct enrichment of edible oils (sunflower, rape seed, olive, and soya) with SBT carotenoids. These oils do not naturally contain carotenoids. After a preliminary study, a RSM has been used to maximize total carotenoid content of extracts and the influence of process variables on the UAE has been investigated. The results provided by the statistical analysis revealed that the optimized conditions were: sonication power of 0.67 W/g oil and a temperature of 35°C. The optimization parameters of this “green” process provide a greatly improved enrichment of the edible oil in terms of quantity and process time from 33.83 mg/L extract in 90 min obtained by conventional extraction to 51.64 mg/L extract in only 20 min by UAE. Ultrasound‐assisted carotenoids extraction from SBT by‐products appears to be a simple, rapid, and sustainable alternative to conventional procedures.Practical applications: Improving the value of low quality edibles is important for the food, cosmetic, or nutraceutical industry. It is done by adding ingredients such as carotenoids which are extracted by hexane or other solvents. In this study we show an innovative application of a direct extraction by maceration of by‐products in edible oil without solvent and eliminating evaporation and extraction unit operations. Using ultrasound, full extractions can now be completed in minutes with high reproducibility, reducing the consumption of solvent, simplifying manipulation and work‐up, giving higher purity of the final product, eliminating post‐treatment of waste water, and consuming only a fraction of the fossil energy normally needed for a conventional extraction method such as Soxhlet extraction, maceration, or steam distillation.
Tabernaelegantinals: Unprecedented Cytotoxic Bisindole Alkaloids from Muntafara sessilifolia
Authors: Girardot Marion , Gadea Alice , Deregnaucourt Christiane , Deville Alexandre , Dubost Lionel , Nay Bastien , Maciuk Alexandre , Rasoanaivo Philippe , Mambu Lengo 
Published: April 2012

AbstractBioassay‐guided fractionation of the stem bark of Muntafara sessilifolia has led to the isolation of six new vobasinyl‐iboga bisindole alkaloids, tabernaelegantinals A, B and E, and (3′R)‐hydroxytabernaelegantines A, C and D, together with six known monomeric indole and two bisindole alkaloids. The structures of these alkaloids were established by NMR and MS analysis. The bisindole alkaloids demonstrated cytotoxicity against the human lung MRC‐5 and rat skeletal muscle L‐6 cell lines whereas only one monomeric indole alkaloid was found to be cytotoxic. Tabernaemontanine acetate was found to be selectively antiplasmodial against the chloroquine‐resistant strain FcB1 of Plasmodium falciparum (5.3 μM IC50) over mammalian cell lines (selectivity index > 45). The tabernaelegantinals share an unprecedented α‐amino aldehyde moiety, the biosynthetic origin of which is discussed.
Direct Aldol Reaction of Pyruvic Derivatives: Catalytic Attempt To Synthesize Ulosonic Acids
Authors: El‐Sepelgy Osama , Schwarzer Darius , Oskwarek Piotr , Mlynarski Jacek 
Published: April 2012

AbstractThe catalytic asymmetric aldol reaction of pyruvic aldehyde dimethyl acetal and 2‐acetylthiazole with sugar aldehydes is demonstrated to be the key step in the synthesis of 3‐deoxy‐2‐ulosonic acids. Efficient and stereoselective pyruvate aldol reactions are catalyzed by metal‐based chiral Trost and Shibasaki catalysts. The presented synthetic methodology mimics aldolase‐catalyzed reactions by direct activation of C3 pyruvate equivalents with the use of metal‐based chiral catalysts en route to the synthesis of 2‐keto‐3‐deoxy‐D‐glucosonic acid and 3‐deoxy‐D‐manno‐2‐octulosonic acid derivatives.
Modification of γ‐secretase by nitrosative stress links neuronal ageing to sporadic Alzheimer's disease
Authors: Guix Francesc X. , Wahle Tina , Vennekens Kristel , Snellinx An , Chávez‐Gutiérrez Lucía , Ill‐Raga Gerard , Ramos‐Fernandez Eva , Guardia‐Laguarta Cristina , Lleó Alberto , Arimon Muriel , Berezovska Oksana , Muñoz Francisco J. , Dotti Carlos G. , De Strooper Bart 
Published: April 2012

AbstractInherited familial Alzheimer's disease (AD) is characterized by small increases in the ratio of Aβ42 versus Aβ40 peptide which is thought to drive the amyloid plaque formation in the brain of these patients. Little is known however whether ageing, the major risk factor for sporadic AD, affects amyloid beta‐peptide (Aβ) generation as well. Here we demonstrate that the secretion of Aβ is enhanced in an in vitro model of neuronal ageing, correlating with an increase in γ‐secretase complex formation. Moreover we found that peroxynitrite (ONOO−), produced by the reaction of superoxide anion with nitric oxide, promoted the nitrotyrosination of presenilin 1 (PS1), the catalytic subunit of γ‐secretase. This was associated with an increased association of the two PS1 fragments, PS1‐CTF and PS1‐NTF, which constitute the active catalytic centre. Furthermore, we found that peroxynitrite shifted the production of Aβ towards Aβ42 and increased the Aβ42/Aβ40 ratio. Our work identifies nitrosative stress as a potential mechanistic link between ageing and AD.
Cognitive Set‐Shifting in Anorexia Nervosa
Authors: Shott Megan E. , Filoteo J. Vincent , Bhatnagar Kelly A.C. , Peak Nicole J. , Hagman Jennifer O. , Rockwell Roxanne , Kaye Walter H. , Frank Guido K.W. 
Published: April 2012

AbstractObjectiveAdult anorexia nervosa (AN) is associated with inefficient cognitive flexibility and set‐shifting. Whether such inefficiencies also characterize adolescent AN is an important area of research.MethodAdolescents with AN and matched controls were administered a computerized task that required initial learning of an explicit rule using corrective feedback and learning of a new rule after a set number of trials. Adult patients with AN and controls were also examined.ResultsAdolescents with AN did not differ from matched controls with respect to set‐shifting cost (decrease in performance after rule change), whereas adults with AN had significantly greater set‐shifting cost compared with controls.DiscussionThis study suggests that set‐shifting inefficiencies may not be a vulnerability factor for AN development in adolescents with AN, but might become an important aspect of the disorder at later age, and could point towards developmental neurobiologic brain changes that could affect AN at different ages. Copyright © 2012 John Wiley & Sons, Ltd and Eating Disorders Association.
Comparison of Obese and Nonobese Individuals with Binge Eating Disorder: Delicate Boundary Between Binge Eating Disorder and Non‐Purging Bulimia Nervosa
Authors: Carrard Isabelle , der Linden Martial Van , Golay Alain 
Published: April 2012

ABSTRACTObjectiveTo compare obese and nonobese individuals with binge eating disorder (BED) on demographic data, illness history, eating disorders and psychological health.MethodsThis study used baseline data from a randomized controlled study on the efficacy of an online cognitive behavioural self‐help treatment. Seventy‐four women aged between 18 and 60 years were recruited in the community. They had to meet full or subthreshold diagnostic criteria for BED according to Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition.ResultsForty per cent of the sample had a body mass index higher than 30 kg/m2. Mean age and severity of eating disorders were similar between obese and nonobese individuals. A statistically significant difference emerged regarding dietary restraint, with nonobese BED individuals exhibiting higher scores than obese BED individuals.ConclusionsDietary restraint might be one of the factors explaining body mass index differences among BED individuals. This raises the question of the boundary between non‐purging bulimia nervosa and BED in nonobese people. Copyright © 2012 John Wiley & Sons, Ltd and Eating Disorders Association.