bluuebunny/crossref_metadata_2025_split huggingface dataset:
Inverse correlation between clinical response to paroxetine and plasma drug concentration in patients with major depressive disorders
Authors: Yasui‐Furukori Norio , Nakagami Taku , Kaneda Ayako , Inoue Yoshimasa , Suzuki Akihito , Otani Koichi , Kaneko Sunao 
Published: November 2011

ObjectiveThere are few data concerning a clear relationship between the clinical effect of paroxetine and plasma drug concentrations, although therapeutic ranges have been established for some tricyclic antidepressants.MethodsIn this study, 120 patients with major depressive disorders were treated with 10–40 mg/day of paroxetine for 6 weeks, and a total of 89 patients completed the protocol. A clinical evaluation using the Montgomery‐Asberg Depression Rating Scale (MADRS) was performed at 0, 1, 2, 4 and 6 weeks.ResultsSignificant correlations were found between the plasma concentrations of paroxetine and the percentage improvement in the total MADRS scores (r = −0.282, p < 0.01) and the final MADRS scores at 6 weeks (r = 0.268, p < 0.05). The conventional receiver‐operating‐characteristic curve showed the fraction of true positive results and false negative results for various cut‐off levels of paroxetine concentration for response and remission. The thresholds for both response and remission that gave the maximal sensitivity and specificity for paroxetine concentrations were 64.2 ng/ml.ConclusionsThese results suggest that plasma paroxetine concentrations are negatively associated with improvement and that response occurs at the upper threshold of 64.2 ng/ml of paroxetine. These findings should be replicated with a larger patient sample. Copyright © 2011 John Wiley & Sons, Ltd.
Cellular proliferation, cellular viability, and biocompatibility of HA‐ZnO composites
Authors: Saha Naresh , Dubey Ashutosh K. , Basu Bikramjit 
Published: November 2011

AbstractOne of the important issues in the development of hydroxyapatite (HA)‐based biomaterials is the prosthetic infection, which limits wider use of monolithic HA despite superior cellular response. Recently, we reported that ZnO addition to HA can induce bactericidal property. It is therefore important to assess how ZnO addition influences the cytotoxicity property and cell adhesion/proliferation on HA‐ZnO composite surfaces in vitro. In the above perspective, the objective of this study is to investigate the cell type and material composition dependent cellular proliferation and viability of pressureless sintered HA‐ZnO composites. The combination of cell viability data as well as morphological observations of cultured human osteoblast‐like SaOS2 cells and mouse fibroblast L929 cells suggests that HA‐ZnO composites containing 10 Wt % or lower ZnO exhibit the ability to support cell adhesion and proliferation. Both SaOS2 and L929 cells exhibit extensive multidirectional network of actin cytoskeleton and cell flattening on the lower ZnO containing (≤10 Wt %) HA‐ZnO composites. The in vitro results illustrate how variation in ZnO content can influence significantly the cell vitality, as evaluated using MTT biochemical assay. Also, the critical statistical analysis reveals that ZnO addition needs to be carefully tailored to ensure good in vitro cytocompatibility. The underlying reasons for difference in biological properties are analyzed. It is suggested that surface wettability as well as dissolution of ZnO, both contribute to the observed differences in cellular viability and proliferation. © 2011 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2012.
A computational chemist approach to gas sensors: Modeling the response of SnO2 to CO, O2, and H2O Gases
Authors: Ducéré Jean‐Marie , Hemeryck Anne , Estève Alain , Rouhani Mehdi Djafari , Landa Georges , Ménini Philippe , Tropis Cyril , Maisonnat André , Fau Pierre , Chaudret Bruno 
Published: November 2011

AbstractA general bottom‐up modeling strategy for gas sensor response to CO, O2, H2O, and related mixtures exposure is demonstrated. In a first stage, we present first principles calculations that aimed at giving an unprecedented review of basic chemical mechanisms taking place at the sensor surface. Then, simulations of an operating gas sensor are performed via a mesoscopic model derived from calculated density functional theory data into a set of differential equations. Significant presence of catalytic oxidation reaction is highlighted. © 2011 Wiley Periodicals, Inc. J Comput Chem, 2012
Iatrogenic arteriovenous fistula in the Arm in an infant: Diagnostic and therapeutic considerations
Authors: Kotagal Meera , Reiss Aya , Vo Nghia , Feldman Kenneth , Drugas George , Avansino Jeffrey R. 
Published: November 2011

AbstractIatrogenic arteriovenous fistulas (AVF) are well described in adults; however, this complication is rarely described and reported in infants. We report the case of a 3‐month‐old infant with complicated gastroschisis requiring multiple venipunctures who presented with signs and symptoms suggestive of traumatic arteriovenous fistula. Ultrasound imaging confirmed the presence of a wide‐necked AVF between the brachial artery and vein. The fistula was surgically repaired. This case report describes the clinical imaging and treatment options for infants with iatrogenic AVF. © 2011 Wiley Periodicals, Inc. J Clin Ultrasound, 2012
Heterothermy in two mole‐rat species subjected to interacting thermoregulatory challenges
Authors: Boyles Justin G. , Verburgt Luke , McKechnie Andrew E. , Bennett Nigel C. 
Published: November 2011

ABSTRACTMaintaining a high and constant body temperature (Tb) is often viewed as a fundamental benefit of endothermy, but variation inTbis likely the norm rather than an exception among endotherms. Thus, attempts to elucidate which factors causeTbof endotherms to deviate away from theTbthat maximizes performance are becoming more common. One approach relies on an adaptive framework of thermoregulation, used for a long time to predict variation inTbof ectotherms, as a starting point to make predictions about the factors that should lead to thermoregulatory variation in endotherms. Here we test the predictions that when confronted with thermoregulatory challenges endotherms should (1) become more heterothermic, (2) lower theirTbsetpoint, and/or (3) increase behavioral thermoregulation (e.g., activity levels or social thermoregulation). We exposed two species of relatively homeothermic mole‐rats to two such challenges: (a) ambient temperatures (Ta) well below the thermoneutral zone and (b) increased heat loss caused by the removal of dorsal fur. In general, our results support the adaptive framework of endothermic thermoregulation with each species conforming to some of the predictions. For example, Mashona mole‐rats (Fukomys darlingi) increased heterothermy asTadecreased, highveld mole‐rats (Cryptomys hottentotus pretoriae) displayed lowerTb's after shaving, and both species increased behavioral thermoregulation asTadecreased. This suggests that there is some merit in extending the adaptive framework to endotherms. However, none of the three predictions we tested was supported under all experimental conditions, reiterating that attempts to determine universal factors causing variation inTbof endotherms may prove challenging.J. Exp. Zool. 317:73–82, 2012. © 2011 Wiley Periodicals, Inc.
Polycyclic N‐Heterocyclic Compounds, Part 69: Synthesis of 5‐amino‐1,2‐dihydro[1]benzofuro[3,2‐d]furo[2,3‐b]pyridines and their transformations to related compounds
Authors: Okuda Kensuke , Takano Jun‐ichi , Hirota Takashi , Sasaki Kenji 
Published: November 2011

AbstractReaction of 3‐(3‐cyanopropoxy)[1]benzofuran‐2‐carbonitriles with potassium tert‐butoxide gave 5‐amino‐1,2‐dihydro[1]benzofuro[3,2‐d]furo[2,3‐b]pyridines and 5‐amino‐2,3‐dihydro[1]benzofuro[3,2‐b]oxepin‐4‐carbonitriles as new ring systems. Reactions of the 5‐chloro derivative, obtained from 5‐amino‐1,2‐dihydro[1]benzofuro[3,2‐d]furo[2,3‐b]pyridine, produced a dihydrofuran ring‐opened compound and 5‐substituted compounds. J. Heterocyclic Chem.,(2011).
2‐amino‐X‐nitrobenzimidazoles as precursors of food‐borne carcinogens: A new approach to IQ synthesis
Authors: Bella Maroš , Milata Viktor , Larina Lyudmila I. 
Published: November 2011

AbstractCyclization of (non)‐methylated nitro‐o‐phenylenediamines with cyanogen bromide provided nitro‐substituted 2‐aminobenzimidazoles in good up to excellent yields. Catalytic hydrogenation of 2‐amino‐1‐methyl‐5‐nitrobenzimidazole yielded 2,5‐diamino‐1‐methylbenzimidazole, which on treatment with 1,1,3,3‐tetramethoxypropane in methanol and subsequently after removal of methanol in polyphosphoric acid afforded food‐borne carcinogen 2‐amino‐3‐methylimidazo[4,5‐f]quinoline (IQ) in 20% yield. J. Heterocyclic Chem.,(2011).
Modelling monthly diffuse solar radiation fraction and its validity over the Indian sub‐tropics
Authors: Singh Jyotsna , Bhattacharya Bimal K. , Kumar Manoj , Mallick Kaniska 
Published: November 2011

AbstractA three‐parameter sigmoidal ‘local’ model (climate‐specific) and a ‘regional’ model (common for all climates) have been developed for measuring the monthly average diffuse solar radiation fraction from atmospheric transmissivity by using large, 21‐year datasets (1973–1993) over four stations (Jodhpur, New Delhi, Nagpur and Kolkata). These stations represent the four ‘prime’ climates (arid, semi‐arid, sub‐humid and humid) over the Indian sub‐tropics. The models have been validated with the longer time‐series (10 years) of independent datasets (1994–2003) of 4 ‘prime’ climates as well as datasets from 16 stations using one‐year datasets (termed as secondary stations) of the Indian region. The monthly diffuse fraction estimates were also compared with seven globally existing models. The ‘regional’ model showed more accurate estimates than ‘local’ models over three (semi‐arid, sub‐humid and humid) of the four ‘prime’ climates. However, the different error statistics showed that the ‘regional’ model outperformed the globally existing models which failed to capture diffuse fraction variability over the Indian sub‐tropics. The extendibility of the ‘regional’ model over ‘secondary’ stations in India showed an overall good performance withR2: 0.78–0.96 andRMSE: 0.017–0.125, except for two stations. These models are unique for Indian sub‐tropics and can undoubtedly be used for predicting future diffuse solar radiation fraction from transmissivity datasets of climate simulations, and also for other meteorological, climatological, solar energy‐based applications. Copyright © 2011 Royal Meteorological Society
Thoracic recurrent laryngeal lymph node metastases predict cervical node metastases and benefit from three‐field dissection in selected patients with thoracic esophageal squamous cell carcinoma
Authors: Li Hecheng , Yang Su , Zhang Yawei , Xiang Jiaqing , Chen Haiquan 
Published: November 2011

AbstractBackground and ObjectivesRecurrent laryngeal nerve lymph nodes (RLN LNs) are considered sentinel nodes for cervical LN metastases of esophageal cancer. Surgery is the treatment of choice, but whether three‐field lymph node dissection (3FL), which includes cervical LN dissection, or 2FL, which does not, should be performed is controversial.MethodsWe retrospectively analyzed medical records of 200 patients with esophageal cancer who underwent 3FL from January 2000 to August 2010, focusing on LN status. We also compared survival rates between these patients and those who underwent 2FL.ResultsThe rate of cervical LN metastases did not differ significantly between RLN LN+ (for metastasis) and RLN LN− 3FL groups. However, in a subgroup of patients with middle/lower thoracic esophageal tumors, cervical LN metastases were significantly more common in patients with positive rather than negative RLN LNs. Survival did not differ after 3FL versus 2FL in general. However, 3FL was associated with longer survival than 2FL in patients with RLN LN positivity and either lower thoracic esophageal tumors or more than four abdominal/thoracic LN metastases.ConclusionsMetastasis to RLN LNs is a reliable indicator of cervical LN metastasis in middle/lower thoracic esophageal cancer, while 3FL offers survival benefit over 2FL in certain patient subgroups. J. Surg. Oncol. 2012; 105:548–552. © 2011 Wiley Periodicals, Inc.
Stereoselective separation and determination of triadimefon and triadimenol in wheat, straw, and soil by liquid chromatography–tandem mass spectrometry
Authors: Liang Hongwu , Qiu Jing , Li Li , Li Wei , Zhou Zhiqiang , Liu Fengmao , Qiu Lihong 
Published: November 2011

AbstractA sensitive and rapid analytical method was developed for simultaneous determination of triadimefon (TF) and triadimenol (TN) stereoisomers in wheat, straw, and soil by liquid chromatography coupled with triple quadrupole mass spectrometry (LC‐MS/MS). The direct enantioseparation of TF and TN was performed on a Lux cellulose‐1 column packed with cellulose‐tris‐(3,5‐dimethylphenylcarbamate). The effects of mobile‐phase composition on the separation were investigated and stereoisomeric elution orders were confirmed with a polarimeter detector. The pesticides were extracted from samples with acetonitrile and cleaned up by solid‐phase extraction or activated carbon. Based on the developed stereoselective LC‐MS/MS method, for TF and TN stereoisomers, good linearities were obtained over the concentration range of 0.003–4 mg/L; recoveries were 84.2–102.7% in wheat, 84.0–104.0% in straw, and 85.2–106.8% in soil at spiked concentrations of 0.007–2.0 mg/kg; intra‐day and inter‐day assay precisions were below 12.2%. Limits of detection (LODs) and limits of quantification (LOQs) in wheat, straw, and soil were 0.001–0.005 mg/kg and 0.007–0.02 mg/kg, respectively. Finally, the method was successfully applied to detect TF and TN stereoisomers in wheat, straw, and soil samples from residual trials in farm.
Global proteomics and metabolomics in cancer biomarker discovery
Authors: Issaq Haleem J. , Fox Stephen D. , Chan King C. , Veenstra Timothy D. 
Published: November 2011

AbstractChromatography and electrophoresis have been used for the last half‐century to separate small and large molecules. Advances in MS instrumentation and techniques for sample introduction into the mass analyzer (i.e. matrix‐assisted laser desorption/ionization and electrospray ionization), chromatography in all its formats and modes and two‐dimensional gel electrophoresis, including two‐dimensional difference gel electrophoresis, enabled the separation of complex biological mixtures, such as the proteome and the metabolome, in a biological sample. These advances have made it possible to identify compounds that can be used to discriminate between two samples taken from healthy and diseased individuals. The objective is to find proteins or metabolites that can be used as a clinical test for the early diagnosis, prognosis and monitoring of the disease and the outcome of therapy. In this manuscript, we present an overview of what has been achieved in the search for biomarkers, with emphasis on cancer, using separation science and MS.
Neuroradiologic findings and follow‐up with magnetic resonance imaging of the genetic forms of haemophagocytic lymphohistiocytosis with CNS involvement
Authors: Rego Ines , Severino Mariasavina , Micalizzi Concetta , Faraci Maura , Pende Daniela , Dufour Carlo , Aricò Maurizio , Rossi Andrea 
Published: November 2011

AbstractHaemophagocytic lymphohistiocytosis (HLH) is a rare hyperinflammatory syndrome caused by deficient down‐regulation of the immune response. Presence of central nervous system (CNS) involvement at diagnosis is a poor prognostic sign, and should be carefully investigated. Herein, we describe the neuroradiological findings, clinical data, and treatment outcome in 12 patients with genetic HLH and CNS complications. Neuroimaging was important in identifying CNS involvement, monitoring treatment responses, and detecting treatment complications. Pediatr Blood Cancer 2012; 58: 810–814. © 2011 Wiley Periodicals, Inc.
Cell cycle‐specific function of Ikaros in human leukemia
Authors: Li Zhanjun , Song Chunhua , Ouyang Hongsheng , Lai Liangxue , Payne Kimberly J. , Dovat Sinisa 
Published: November 2011

AbstractBackgroundThe loss of Ikaros is associated with the development of B and T cell leukemia. Data on Ikaros function, including its role as a tumor suppressor and a regulator of cell cycle progression, come almost exclusively from murine studies; little is known of the mechanisms that regulate human Ikaros function. Our studies are the first to examine the function and regulation of human Ikaros isoforms during the cell cycle in human ALL.ProceduresElectromobility shift assay (EMSA), confocal microscopy, and phosphopeptide mapping were used to study Ikaros function during different stages of the cell cycle.ResultsThe DNA‐binding activity of human Ikaros complexes undergoes dynamic changes as the cell cycle progresses. In S phase, Ikaros DNA‐binding affinity for regulatory regions of its target genes decreases, while its binding to pericentromeric heterochromatin is preserved and correlates with Ikaros pericentromeric localization. These S phase‐specific changes in Ikaros function are controlled by phosphorylation via the CK2 kinase pathway. During cell cycle progression, the subcellular pericentromeric localization of the largest human Ikaros isoforms is different from that in mouse cells, suggesting unique functions for human Ikaros.ConclusionsOur results demonstrate that the function of Ikaros is cell cycle‐specific and controlled by CK2‐mediated phosphorylation during S phase of the cell cycle in human T‐cell and B‐cell ALL. The differences we observe in murine and human Ikaros function highlight the importance of using human cells in studies of ALL. These data identify the CK2 pathway as a target for therapies in ALL. Pediatr Blood Cancer 2012; 59: 69–76. © 2011 Wiley Periodicals, Inc.
Surface engineering in Cu(In,Ga)Se2 solar cells
Authors: Schleussner Sebastian Michael , Pettersson Jonas , Törndahl Tobias , Edoff Marika 
Published: November 2011

ABSTRACTSurface modifications of three‐stage co‐evaporated Cu(In,Ga)Se2 (CIGS) thin films are investigated by finishing the evaporation with gallium‐free (CuInSe2, CIS) stages of various lengths. Secondary‐ion mass spectrometry shows substantial interdiffusion of indium and gallium, smearing out the Ga/(Ga + In) profile so that the addition of a CIS layer merely lowers the gallium content at the surface. For the thinnest top layer, equivalent to 20 nm of pure CIS, X‐ray photoelectron spectroscopy does not detect any compositional difference compared with the reference device. The modifications are evaluated electrically both by temperature‐dependent characterisation of actual solar‐cell devices and by modelling, using the latest version of scaps‐1d (Electronics and Information Systems, Ghent University, Belgium). The best solar‐cell device from this series is obtained for the 20 nm top layer, with an efficiency of 16.6% after antireflective coating. However, we observe a trend of decreasing open‐circuit voltage for increasingly thick top layers, and we do not find direct evidence that the lowering of the gallium concentration at the CIGS surface should generally be expected to improve the device performance. A simulated device with reduced bulk and interface defect levels achieves nearly 20% efficiency, but the trends concerning the CIS top layer remain the same. Copyright © 2011 John Wiley & Sons, Ltd.
InN grown by migration enhanced afterglow (MEAglow)
Authors: Butcher Kenneth Scott A. , Alexandrov Dimiter , Terziyska Penka , Georgiev Vasil , Georgieva Dimka , Binsted Peter W. 
Published: November 2011

AbstractInN thin films were grown by a new technique, migration enhanced afterglow (MEAglow), a chemical vapour deposition (CVD) form of migration enhanced epitaxy (MEE). Here we describe the apparatus used for this form of film deposition, which includes a scalable hollow cathode nitrogen plasma source. Initial film growth results for InN are also presented including atomic force microscopy (AFM) images that indicate step flow growth with samples having root mean square (RMS) surface roughness of as little as 0.103 nm in some circumstances for film growth on sapphire substrates. X‐ray diffraction (XRD) results are also provided for samples with a full width half maximum (FWHM) of the (0002) ω‐2θ peak of as little as 290 arcsec. Low pressure conditions that can result in damage to the InN during growth are described.
Influence of growth temperature on the twin formation of InN{10$ \bar 1 $3} on GaAs(110) by metalorganic vapor phase epitaxy
Authors: Murakami Hisashi , Cho Hyun‐Chol , Suematsu Mayu , Inaba Katsuhiko , Kumagai Yoshinao , Koukitu Akinori 
Published: November 2011

AbstractTwin formation of {10$ \bar 1 $3} semi‐polar InN layers on GaAs(110) surface has been investigated by metalorganic vapor phase epitaxy (MOVPE). It was found that the growth temperature of InN epitaxial layer strongly affected the twin formation due to the difference in the durability of In‐polar and N‐polar InN crystal at each growth temperature. From the results of polarity determination and pole figure measurements by high resolution X‐ray diffraction (HR‐XRD), InN layers grown at high temperatures showed a single domain (no twinning) and the direction of 〈0001〉 InN paralleled to the direction of 〈11$ \bar 1 $〉B GaAs, implying the epitaxial relationship to be (10$ \bar 1 $$ \bar 3 $)//GaAs(110). On the contrary, InN layers grown at relatively low temperatures contained the twin crystal and the [0001] InN of each domain paralleled to either 〈111〉A or 〈11$ \bar 1 $〉B of GaAs. (© 2012 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Reduction of reverse‐bias leakage current in GaN‐based Schottky‐type light‐emitting diodes by surface modification using the aluminum facepack technique
Authors: Honda Tohru , Sakai Naoyuki , Komiyama Shigetoshi , Hayashi Masato , Igaki Tatsuhiro 
Published: November 2011

AbstractWe investigated the reduction of the large reverse‐bias leakage current in GaN‐based Schottky diodes using the aluminum facepack technique, which involves the evaporation of aluminum onto the nitride surface, the subsequent oxidation of the Al film in air, and its removal by a wet‐etching technique. The reduction of the reverse‐bias leakage current was due to the mask effect of the facepack, which reduced the number of dislocation‐related leakage current paths. This reduction leads to the enhancement of quantum efficiency in Schottky‐type light‐emitting diodes (© 2012 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Effect of growth conditions on magnetic and structural properties in Gd‐doped GaN layers grown by plasma‐assisted molecular beam epitaxy
Authors: Hasegawa Shigehiko , Komori Sachio , Higashi Kotaro , Abe Daijiro , Zhou Yi‐Kai , Asahi Hajime 
Published: November 2011

AbstractEffects of growth conditions on structural and magnetic properties in Gd‐doped GaN layers grown by plasma‐assisted molecular beam epitaxy have been investigated. It is found that the growth of Gd‐doped GaN layers with atomically flat surface morphologies requires relatively high Ga fluxes compared with the growth of GaN. For these Gd‐doped GaN layers grown under Ga‐rich conditions, (0002) diffraction spots of GaGdN appear and shift toward low scattering angle side depending on the concentration of Gd, indicating the expansion of the c‐axis lattice constant due to the incorporation of Gd. In contrast, for the Gd‐doped GaN layers grown under N‐rich condition, just the (0002) diffraction spot of GaN is observed irrespective of the concentration of Gd. Although all the samples show hysteresis in the M‐H curves at room temperature, the samples grown under the Ga‐rich conditions have higher coercevities and larger saturation magnetizations than the samples grown under the N‐rich conditions. Based on the findings, we will discuss the origin of ferromagnetic behaviour observed in Gd‐doped GaN (© 2012 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)