bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Association of Chlamydia trachomatis / Gonococcal Infection and Tubal Factor Infertility
Authors: Swasdio K. , Rugpao S. , Tansathit T. , Uttavichai C. , Jongusuk P. , Vutayavanich T. , Oranratanachai A. , Pruthitada N. , Peerakom S. , Ittipunkul W. , Rowe P. J. , Ward M. E. 
Published: August 2010

AbstractObjective: To determine the association of past Chlamydia trachomatis and past Neisseria gonorrhoeae infection with tubal factor infertility.Methods: A cross‐sectional study was conducted. Cases consisted of 55 primary infertile women with laparoscopy confirmed tubal damage (group A) and their husbands, consecutively attending the Infertility Unit at Maharaj Nakorn Chiang Mai Hospital between 1990 and 1992; and 58 primary infertile women with laparoscopy confirmed normal tubes (group B) and their husbands, consecutively attending the same hospital over the same period. Controls consisted of 59 postpartum women (group C) and their husbands omitted to the same hospital over the same period as cases. Past chlamydial and gonococcal infections were assessed by measuring serum IgG antibodies by enzyme immunoassay (EIA). The EIA antigens consisted of purified elementary bodies of C. trachomatis serovar L1, or purified alpha pili of N. gonorrhoeae strain P9.Results: The prevalence of positive IgG antibody to gonococcal pili in sera from group A was 29.1%, significantly higher than the prevalence of 5.2% in group B or 3.4% in group C (p = 0.000). The husbands of women in group A had a significantly higher prevalence of IgG antibody to gonococcal pili (36.4%) than the husbands of women in group B (8.6%) or group C (18.6%) (p = 0.002). There was no significant difference in positive IgA antibody between case and control groups. After controlling for age, group A showed significantly higher prevalences of past gonorrhea (OR = 32.4, 95% CI 4.3, 242.2) and past chlamydial infection (OR = 3.2, 95% CI 1.2, 8.5) than group C. The husbands of women in group A also had higher prevalences of both types of infection than the husbands of women in group C; the odds ratios for past gonorrhea or chlamydial infections were 2.8 (95% CI 1.1, 6.9) and 2.9 (95% CI 1.2, 7.1), respectively. Neither infertile women with normal tubes (group B) nor their husbands showed any difference when compared with controls.Conclusion: These results suggest that in this region of northern Thailand there is an association between past gonorrhea and past chlamydial infection and tubal factor infertility.
Uterine Cervical Clear‐Cell Adenocarcinoma with a Choriocarcinomatous Component: A Case Report
Authors: Morimura Yutaka , Yazawa Mihoko , Hoshi Kazuhiko , Takano Yoshimasa , Hang Xiang Li , Honda Tsuyoshi , Sato Akira 
Published: August 2010

AbstractA 55‐year‐old woman presented with vaginal bleeding. A tumor was found in the cervix; it was composed of 2 distinctive elements: a clear‐cell adenocarcinoma and a choriocarcinoma. Histologic findings suggested that the choriocarcinomatous element was derived from a preexisting clear‐cell adenocarcinoma through a metaplastic process.
The Role of Transvaginal Ultrasonography and Colour Doppler Imaging in the Detection of Ectopic Pregnancy
Authors: Chew S. , Anandakumar C. , Vanaja K. , Wong Y. C. , Chia D. , Ratnam S. S. 
Published: August 2010

AbstractObjective: To assess the use of transvaginal ultrasound and colour Doppler imaging in the detection of ectopic pregnancy.Materials and Methods: Seventy‐one patients with suspected ectopic pregnancies had transvaginal sonography and colour Doppler imaging performed and 61 ectopic pregnancies were confirmed at surgery. Various ultrasound features on transvaginal B mode scanning were noted and the resistance index of peritrophoblastic flow in the adnexal masses computed.Results: The use of transvaginal B mode imaging alone in the diagnosis of ectopic pregnancy achieved a sensitivity of 98% and a positive predictive value of 86%. The mean gestational age at time of diagnosis was 6 weeks 5 days (range 4 weeks to 13 weeks 2 days). The use of transvaginal colour flow imaging did not increase detection rates of ectopic pregnancy. The mean RI values for patients with or without ectopic pregnancy were almost identical.Conclusion: Colour Doppler imaging failed to improve on the results of transvaginal B mode sonography in the detection of ectopic pregnancy.
Genital Chlamydia trachomatis Infection in Egyptian Women: Incidence among Different Clinical Risk Groups
Authors: El‐Shourbagy Mahmoud , Abd‐El‐Maeboud Karim , Diab Khaled M. , El‐Ghannam Alaa , Nabegh Lila , Ammar Samia 
Published: August 2010

AbstractObjective: To investigate genital Chlamydial infection incidence among high risk clinical conditions in Egyptian women.Methods: A case control study in Ain Shams University Hospital involving 501 patients with cervicitis (n = 58), abnormal cervical smear (n = 256), tubal infertility (n = 85), ectopic pregnancy (n = 22), preterm labour (n = 80) and 192 controls. Active cervical Chlamydial infection was diagnosed using direct immunofluorescent technique. Data were analyzed by Chi‐square (X2 and Z tests.Results: Significant increase of Chlamydial infection among different clinical conditions compared to controls. The percentage of positive chlamydial infection was 79.3% among cervicitis group, 33.3% among subjects with inflammatory smear, 75.2% among those with cervical condyloma, 82.6% among those with cervical intraepithelial neoplasia, 51.8% among tubal infertility subjects, 77.2% among ectopic patients and 56.3% among subjects with preterm labour.Conclusion: The incidence of Chlamydial infection in these high risk Egyptian patients is relatively high. Emperical treatment is recommended as the diagnosis is costly and usually not available.
Cytokines Concentrations in the Cervical Mucus of Pregnant Women
Authors: Sagawa Tadashi , Furuta Itsuko , Negishi Hiroaki , Kishida Tatsuro , Begum Sayeda , Fujimoto Seiichiro 
Published: August 2010

AbstractObjective: Interleukin‐1α, interleukin‐1β, interleukin‐6 and interleukin‐8 in specimens of cervical mucus were assayed to assess defense mechanisms against infection in the cervical canal during pregnancy.Methods: Two hundred and thirty‐nine pregnant women who attended the obstetrics outpatient clinic in our hospital were included as subjects. Cervical mucus was collected with a newly developed collection swab, and cytokines and granulocyte elastase in the samples of cervical mucus were quantified using enzyme immunoassay kits. The 1‐factor ANOVA, the Kruskal‐Wallis test, and scheffé's F were used for statistical analysis.Results: Interleukin‐1α, interleukin‐1β and interleukin‐8 levels rose significantly as the concentrations of granulocyte elastase increased. High concentrations of interleukin‐1α (75.36 ± 19.93 pg/ml) and inteukin‐1β (1005.29 ± 238.75 pg/ml) and interleukin‐8 (4822.4 ± 633.2 pg/ml) were found in the specimens from the group of high granulocyte elastase levels.Conclusions: These cytokines might be involved in defense mechanisms against ascending infection from the vagina.
Comparative Cytogenetic Studies of Benign, Borderline, and Malignant Epithelial Ovarian Tumors
Authors: Izutsu Toshihiko , Kudo Tomohiko , Shoji Tadahiro , Nishiya Iwao 
Published: August 2010

AbstractComparative cytogenetic studies were performed in 40 cases of untreated epithelial ovarian tumors. Of these 40 tumors, 13 were classified as benign, 3 as borderline, and 24 as malignant, according to the WHO classification for ovarian tumors. Of 13 benign ovarian tumors, 4 (30.8%) showed chromosomal abnormalities. Of 4 ovarian tumors, 3 (75%) had single chromosomal abnormalities, and the remaining tumor (25%) retained multiple chromosomal abnormalities.Of 3 borderline‐malignant ovarian tumors, 2 (66.7%) showed chromosomal abnormalities. Of 2 ovarian tumors, 1 (50%) indicated single chromosomal abnormalities, and the remaining tumor (50%) revealed multiple chromosomal abnormalities.Of 24 malignant ovarian tumors, 20 (83.3%) showed chromosomal abnormalities. Of these 20 ovarian tumors, 3 (15%) had single chromosomal abnormalities, and the other 17 (85%) exhibited multiple chromosomal abnormalities.These data indicate that the rate of chromosomal abnormalities, especially multiple abnormalities, increases following the progression of malignancy in epithelial ovarian tumors.
A Study on Fetal Urinary Tract Anomaly: Antenatal Ultrasonographic Diagnosis and Postnatal Follow‐Up*
Authors: Kim Eun‐Kyung , Song Tae‐Bok 
Published: August 2010

AbstractObjective: To evaluate the incidence, associated anomalies, and the type of congenital urinary tract anomaly and to know the cause of congenital hydronephrosis.Methods: In 4.5 years, 5,442 fetuses had ultrasonography and 48 cases of fetal urinary tract anomaly were detected. Ultrasonogram was done after delivery with further examination as necessary.Results: The incidence of all types of anomaly was 4.3% (236/5,442) and the incidence of urinary tract anomaly was 0.9% (48/5,442, 8.8/1,000 births) of all babies born and 20.3% (48/236) of entire anomaly. Types of urinary tract anomaly were as follows; hydronephrosis (37 cases), multicystic dysplastic kidney (5 cases), polycystic kidney disease (2 cases), renal agenesis (2 cases), ectopic kidney (1 case) and hypoplastic kidney (1 case). Associated anomalies were found in 8 cases (16.7%) among 48. Causes of hydronephrosis were ureteropelvic obstruction in 13 cases, ureterovesical obstruction in 4 cases, vesicoureteral reflux in 2 cases, proximal ureteral obstruction in 2 cases, and no specific causes in 16 cases.Conclusions: Antenatal ultrasonography is a very useful diagnostic tool in the detection of urinary tract anomaly and a careful search for other anomalies is indicated when urinary tract anomaly is found.
A Rapid Serological Detection Method for Squamous Cell Carcinoma
Authors: Yoshizawa Hiroyuki , Yamauchi Susumu , Kenjo Takiko , Kuroshima Yoshio , Makino Tsunehisa 
Published: August 2010

AbstractObjective: We conjugated the squamous cell carcinoma (CA)‐associated antibody (anti‐YM antibody) with gelatin particles. We found that these particles reacted specifically with the tumor‐associated antigen (YM antigen) in serum samples from patients with squamous cell CA of the uterine cervix and various organs (GPA reaction).Methods: 1) We performed immunohistochemical studies of the YM antigen in dysplasia and invasive squamous cell CA of the uterine cervix; 2) We measured the GPA reaction in various malignant and non‐malignant gynecologic diseases.Results: 1) Immunohistochemical localization of the YM antigen was over 75% in cases of dysplasia and invasive squamous cell CA of the uterine cervix, and was 21% in normal squamous epithelium of the uterine cervix. 2) The GPA reaction in gynecologic diseases was positive in 57.1% of the dysplasia cases; in CIS cases, 69.2%; in cervical CA, 83.0%; in corpus CA, 25.0%; in leiomyoma 16.7%; and in pregnant serum samples, 66.7%. 3) GPA reactions in non‐ob‐gyn cases were positive in 68.8% of the cases of squamous cell CA of the head and neck; 66.7% in cases of squamous cell CA of the lung; and 25.0% in adenoCA of the lungs whereas the sera of patients with benign tumors and of healthy persons were free of the YM antigen.Conclusion: We concluded that this newly developed GPA‐reaction measurement is a simple and reliable serologic test for detecting the initial stage of squamous cell CA of various organs and for monitoring its postoperative status.
Simultaneous Intra‐ and Extra‐Uterine Pregnancy with Ovarian Hyperstimulation Syndrome after Induction of Ovulation: A Case Report
Authors: Fujii Miho , Mori Satoko , Goto Taeko , Kiya Tamotu , Yamamoto Hiroshi , Ito Eiki , Kudo Ryuichi 
Published: August 2010

AbstractWe present a case of polycystic ovary syndrome (PCOS) that developed simultaneous intra‐ and extra‐uterine pregnancy with ovarian hyperstimulation syndrome (OHSS) after induction of ovulation with pure FSH‐HCG. At 9 weeks of pregnancy, the bilateral tubal pregnancy caused an imminent spontaneous abortion, and both Fallopian tubes were resected. After the laparotomy, the pregnancy progressed without problems until 31 weeks and 5 days of pregnancy, when signs of spontaneous abortion appeared, and healthy twin female babies were delivered by cesarian section. The incidence of heterotopic pregnancy is increasing in cases in which inducers of ovulation or ART, such as IVF‐ET and GIFT, have been employed. One must be well aware that the danger of heterotopic pregnancy following induction of ovulation is imminent, particularly in cases with risk factors of multiple and/or extrauterine pregnancy, such as PCOS, a history of tubal restoration, and sexually transmitted disease(s).
Immunotherapy with Husband's Leukocytes to Primary Habitual Aborters and Autoantibodies in Their Sera
Authors: Takesako Shunji , Fujino Toshinori , Shiokawa Hironobu , Iwamoto Ichiro , Ikeda Toshiro , Nagata Yukihiro 
Published: August 2010

AbstractObjective: This study was performed to determine whether primary habitual aborters have an autoimmunological tendency and whether immunotherapy with leukocytes induces autoantibodies in their sera.Methods: We measured the levels of antiphospholipid antibodies (APAs) and antinuclear antibodies (ANAs) in the sera of 65 primary habitual aborters. Among them, 8 primary habitual aborters received immunotherapy with their respective husband's leukocytes; these 8 patients were followed up for autoantibodies in their sera before immunotherapy, at the time of pregnancy permission, during the first trimester of pregnancy, at delivery, and postpartum.Results: Sixty‐nine percent of the 65 primary habitual aborters were positive for IgG or IgM antibodies to at least 1 of 6 phospholipids, and 29% of them were positive for ANAs. Although the pregnancy outcomes of the 8 primary habitural aborters after immunotherapy were good, their APAs and ANAs converted to positive after the immunotherapy.Conclusion: Immunotherapy with leukocytes should be performed after checking and confirming the absence of autoantibodies in the sera of a habitual aborter.
Pregnancy with Scrub Typhus and Vertical Transmission: A Case Report
Authors: Suntharasaj T. , Janjindamai W. , Krisanapan S. 
Published: August 2010

AbstractScrub typhus is a rickettsian disease which is seldom found in pregnancy. A 31‐year‐old, 34 weeks pregnant woman presented with fever, chill and cough for 6 weeks. Fetal jeopardy was found then a cesarean section was performed to deliver a 2,200 g male with hepatosplenomegaly. The mother's diagnosis was confirmed by positive Weil‐Felix (OXK titer 1: 320) and scrub typhus (titer 1: 1600) tests. Vertical transmission was also demonstrated by a positive scrub typhus IgM in her child.
Dense Acetowhite: A High Grade Lesion?
Authors: Sianturi M. H. Roy 
Published: August 2010

AbstractTo describe the ability of colposcopy in predicting the high grade squamous intraepithelial lesion (SIL) a retrospective, descriptive study was undertaken from January 1, 1993 until November 30, 1995. Agreement between colposcopy and histology results was described in unweighted Kappa. Agreement between colposcopy diagnosis and histology results taken from the dense acetowhitening areas was poor (Kappa 0.5). This agreement will be higher in areas of acetowhite that has an abrupt peeling margin in 72/74 cases. It seems that dense acetowhite areas showed high grade lesions in most of cases observed especially if they had also abrupt peeling margin.
Pregnancy Rates Using CC/hMG or hMG Alone
Authors: Ziadeh Saed M. , Zakaria Muhannad R. , Abu‐Hieja Adel 
Published: August 2010

AbstractObjective: The purpose of our study was to determine which of the two drug regimens is more successful in achieving conception in the infertile couple.Subjects: One hundred and sixty women with primary infertility were included in this study. Group A, consisted of 102 patients were treated with clomiphene citrate (CC) and human menopausal gonadotrophin (hMG). Group B, consisted of 58 patients were treated with hMG alone.Methods: This retrospective study was performed between April 1993 and March 1996, to compare the pregnancy rates in women using two drug regimens with ultrasound scan and serum E2 to monitor ovulation induction.Results: The pregnancy rate per patient in Group A was significantly higher than in Group B (46% vs 25.9%) as was the pregnancy rate per treatment cycle (31.3% vs 15.8%) pregnancy loss was lower in Group A than in Group B (17% vs 33.3%).The incidence of multiple pregnancy was 8.5% in Group A, and 13.3% in Group B. While the incidence of ovarian hyperstimulation syndrome was 3% in Group A, and 6.9% in Group B.Conclusions: We concluded that the use of CC + hMG in an assisted conception programme gives a better pregnancy rate 46% than in the hMG alone 25.9%. These data with the use of U/S scan and serum E2 clearly showed that the use of CC + hMG is a successful and safe method for the treatment of infertile patients.
Characterization of Macrophages Isolated from the Maternal Surface of Human Term Placenta by a New Method of Urokinase Treatment*
Authors: Shiokawa Hironobu , Fujino Toshinori , Yashiki Shinji , Nagata Yukihiro , Sonoda Shunrou 
Published: August 2010

AbstractObjectives: This study was performed to establish a new method for isolating macrophages from the maternal surface of human term placenta by urokinase treatment and to characterize their immunological functions.Methods: Macrophages were recovered from the maternal surface of 6 human term placentas by urokinase treatment, adherence to plastic, and density gradient centrifugation using Percoll. The cells retrieved were tested for their surface markers by immunofluorescent staining. Their antigen‐presenting capacity was examined by use of a mixed lymphocytes culture (MLC) test. In 2 cases, human leucocyte antigen (HLA) typing was performed.Results: An average of 4 × 106 macrophage‐like cells were obtained per whole placenta. More than 90% of them were positive for CD14, HLA‐DR, and DQ surface antigens. An MLC test revealed that they had antigen‐presenting capacity. Of the 6 cases, 2 showed positive MLC test results with maternal peripheral‐blood mononuclear cells. In 1 of the 2 cases, macrophages with paternal HLA phenotypes were identified.Conclusion: The urokinase treatment is a new useful method for isolating macrophages from the maternal surface of human term placenta. Using this method, we obtained macrophages of paternal HLA phenotypes (fetal origin) that might have migrated to the maternal surface of human term placenta.
Pregnancy in a Patient of Glanzmann's Thrombasthenia with Antiplatelet Antibodies
Authors: Kashyap Rajesh , Kriplani Alka , Saxena Renu , Takkar D. , Choudhry V. P. 
Published: August 2010

AbstractGlanzmann's thrombasthenia is an autosomal recessive, inherited platelet function disorder. There is an absence of glycoprotein (GP) IIb/IIIa on the platelet membrane which causes reduced platelet aggregation with a defective platelet haemostatic plug formation. The management of bleeding episodes in these patients with platelet transfusions may result in alloimmunization and make the successive transfusions less effective. Pregnancy and delivery is rare in these patients and is associated with a high risk of severe haemorrhage. We describe a primigravida with Glanzmann's thrombasthenia and alloimmunization who developed secondary postpartum haemorrhage and was successfully treated with oral prednisolone.
Granulocytic Sarcoma of Uterine Cervix as Presentation of Acute Myeloid Leukemia: A Case Report and Review of Literature
Authors: Ramble R. , Kochupillai V. , Sharma A. , Kumar L. , Thulkar S. , Sharma M.C. , Mittal S. 
Published: August 2010

AbstractLocalized extramedulary collection of leukemic cells is termed as granulocytic sarcoma. Incidences of 2–8% in acute myeloid leukemia have been reported in various autopsy studies. In female it usually involves ovary. Since most of such tumors are asymptomatic, they are detected only at autopsy. We report here a case who manifested as abnormal vaginal bleeding, large cervical mass, renal failure, and aspergillous fungaemia. The patient died before she could be treated. From the present report it would appear that granulocytic sarcoma at times may precede other manifestations of leukemia.
A Study of γ‐Aminobutyric Acid (GABA) in Amniotic Fluid
Authors: Kobayashi Keiko , Sekizawa Akihiko , Morimoto Taro , Suzuki Akira , Saito Hiroshi , Yanaihara Takumi 
Published: August 2010

AbstractObjective: The purpose of the study was to evaluate the role of gamma aminobutyric acid (GABA), an inhibitory neurotransmitter, in amniotic fluid (AF) during fetal distress, because it has been reported that several neurotransmitters, e.g. norepinephrine, are affected by GABA.Methods: AF was obtained during elective cesarean section (CS,n= 11) and cesarean section due to fetal distress without labor pain (FD,n= 7). Maternal and umbilical‐cord blood, as well as the first urine of the neonates, also were collected. GABA, norepinephrine (NE), and epinephrine (EP) concentrations were measured using HPLC.Results: The GABA concentration was higher in the AF than in either maternal or fetal circulation, or in the first urine of neonates. The GABA concentrations in the AF and in the first urine of neonates were significantly higher in the FD group than in the CS group (p < 0.05). Furthermore, significant positive correlations were observed between the NE and GABA concentrations and between the EP and GABA concentrations in the AF. GABA was produced in a time‐dependent manner in cultured amnion cells.Conclusion: The highest concentration of GABA was found in the AF. The GABA in the AF appeared to be derived from both the amniotic membrane and the fetal urine. The increase in the GABA concentration in cases of fetal distress might be partially derived from the fetus via fetal urine. The positive correlations between the concentrations of GABA and those of NE and EP in the AF, suggest that GABA, NE, and EP might play important roles during fetal distress.
Uterine Cervical Adenocarcinomas and Squamous Carcinomas in Bombay: 1965–1990*
Authors: Krishnamurthy Sarala , Yecole Balkrishna B. , Jussawalla Darab J. 
Published: August 2010

AbstractObjective: To learn if the increased incidence of uterine cervical adenocarcinomas in developed populations exists in developing ones.Methods: We studied age‐adjusted (world) incidence rates of pathologic types of cervical cancer from 1965 through 1990 in the population‐based Bombay Cancer Registry and in the National Cancer Registry's hospital‐based frequencies of 1985–1987. The t‐test was used to measure the statistical significance of change. International comparisons were made.Results: In Bombay, the incidence rates of adenocarcinoma per 106 women rose from 5.0 in 1965 to 12.9 in 1990 (p < 0.05). However, cervical cancers overall declined, from 244 per 106 in 1965 to 176 in 1990 (p < 0.001), squamous carcinomas declined from 167 to 129 per 106 (p < 0.05), other types of cervical cancers declined from 10.9 to 2.9 per 106 women (ns), and nonpathologically diagnosed cervical cancers declined from 61 to 31 per 106 (p < 0.05). Adenocarcinomas were 2.5% of all cervical cancers in Bombay's overall population in 1965, and were 7.0% in 1990; they were only 3.3% in 5 Indian hospital registries but were a higher percent in the Tata Hospital Bombay and internationally. The peak age of adenocarcinoma patients was 50–55 years in Bombay, unlike a younger peak age in the West, and 60–65 years for squamous carcinomas.Conclusion: These Occidental‐type trends might be due to increased awareness of cervical adenocarcinomas and/or changes associated with industrialization. Such trends might occur in other developing countries in the future. Greater awareness of cervical adenocarcinoma and its early diagnosis by endocervical brush cytology are needed in such populations.