bluuebunny/crossref_metadata_2025_split huggingface dataset:
Auto Labeling Untuk Analisis Sentimen Opini Mahasiswa Baru Terhadap Pembelajaran Mata Kuliah Dengan Algoritma K-Nearest Neighbor
Authors: Husdi  , Andi Kamaruddin  
Published: May 2024

Pendidikan adalah usaha sadar dan terencana untuk menciptakan suasana dan proses pembelajaran agar peserta didik secara aktif mengembangkan potensi dirinya untuk memperoleh kekuatan, jiwa keagamaan yang kuat, pengendalian diri, kepribadian, kecerdasan, berakhlak mulia. moralitas dan keterampilan yang dibutuhkannya, masyarakat, bangsa dan negara. Permasalahan utama yang diangkat dalam penelitian ini adalah belum di ketahuinya penilaian mahasiswa baru terhadap pembelajaran di Fakultas Ilmu Komputer untuk melakukan evalusi maupun perbaikan layanan Akademik Kepada Mahasiswa khususnya mahasiswa baru. Solusi yang ditawarkan untuk permasalahan tersebut adalah menganalisa sentimen mahasiswa baru terhadap layanan akademik di Program Studi Teknik Informatika dengan menggunakan Teknik Text Mining. Selanjutnya dugunakan teknik pelabelan otomatis dengan TextBlob sehingga dapat menganalisis sentimen hal tersebut dapat dibuktikan dengan pengujian akurasi dari hasil klasifikasi menggunakan algoritma K-NN dengan akurasi tertinggi sebesar 85%. a. Berdasarkan hasil ekeperimen yang dilakukan didapatkan hasil analisis sentimen oleh mahasiswa baru terhadap pembelajaran matakuliah. Pada grafik tersebut diperlihatkan 76% bernilai positif, 18.4% bernilai netral dan hanya 8.1% bernilai negatif
Dispositivo electrónico para apoyar el aprendizaje inicial de lectura Braille
Authors: Condarco Calderon Yamil 
Published: May 2024

En este artículo se presenta el diseño de un dispositivo electrónico para el apoyo del aprendizaje de lectura de caracteres braille. El sistema de lectoescritura braille permite a las personas con discapacidad visual interactuar con su entorno sin la necesidad de un externo. La finalidad del dispositivo es apoyar a los instructores en el proceso de lectura de los caracteres braille mediante el uso de una aplicación móvil Android que permita aprender los caracteres braille de manera secuencial y también practicar lo aprendido, una base de datos para realizar el seguimiento y un dispositivo simulador de caracteres braille. El dispositivo simulador braille fue diseñado mediante impresión 3D y se comunica con el dispositivo móvil inalámbricamente, se utilizó una base de datos con acceso mediante web y conexión fuera de la red de área local LAN (en inglés: 'Local Area Network', conocido como LAN) mediante el uso de una red privada virtual VPN (en inglés: 'Virtual Private Network', conocido como VPN) para lograr registrar y dar seguimiento del uso del dispositivo. Se logró diseñar un dispositivo que permita apoyar en el proceso de aprendizaje de lectura braille, se realizaron prueba y en coordinación con la regional La Paz del Instituto Boliviano de la Ceguera se obtuvieron recomendaciones que permitirán mejorar el desempeño del dispositivo braille a futuro.
A role of Spirituality and wellbeing at workplace and its connection to happiness and performance of employee working in higher education Institutes
Authors: Dr. Chitralekha Kumar Suvarna Moghe, Dr. Shankar Chaudhary, 
Published: May 2024

Workplace spirituality develops connections and a sense of purpose among employees, which boosts morale and job satisfaction and enhances output, innovation, and teamwork—all of which contribute to improved organizational performance. The objective of the research is to study the effects of practicing workplace spirituality and wellbeing, maintain the happiness that helps to increase better productivity of employee. Research addresses two questions: 1. Does workplace spirituality and wellbeing plays a vital role in happiness of employees in Higher education Institutions. 2. Whether practicing spirituality and wellbeing at workplace affects significantly on performance of employee working in Higher education Institutions. Based on previous study it is found that the, workplace spirituality and wellbeing of academician play a vital role in happiness and practicing spirituality and wellbeing at workplace affects significantly on performance of employees working in Higher Education Institutions.
“Convinsed me a fresh in my hart”: Feeling Moravian in the Eighteenth-Century British World
Authors: Adkins Tucker 
Published: May 2024

ABSTRACT
This article explores the popular spirituality of laymen and laywomen in England’s early Moravian movement. Specifically, the article proposes that British Moravians participated in a deeply “body-centered religion.” Many scholars have portrayed English Moravian piety in far different terms, especially when discussing the “stillness controversy” that fractured the Methodist-Moravian revivalist coalition in 1740. Unlike “noisy” Wesleyans and Whitefieldians, the thinking goes, English Moravians nurtured an interior form of awakened Protestantism that was “quiet,” “still,” “meditative,” “self-abasing,” and “reflective.” By contrast, this article joins the efforts of other emerging scholarship to retrieve the corporeality of Anglo-Moravianism. The author argues that adopting stillness and avoiding the Methodists’ “noise and shew of outward holiness” did not disembody Moravian piety—it necessarily fashioned believers’ bodies into critical sites of Moravian religious formation and subjective spiritual knowledge. The men and women following Nikolaus Ludwig von Zinzendorf’s call to “do nothing but quietly attend the Voice of the Lord” did not suddenly transcend the material world. With stilled flesh and quieted tongues, the physical bodies of Anglo-Brethren recognized, received, and related “a feeling of Grace in my hart.”
PREVALENCE OF GESTATIONAL DIABETES AND RELATED COMPLICATIONS IN DISTRICT SIALKOT
Authors: ZAHRA T , ASHRAF S , AMJAD A , ZAINAB S , IQBAL S , KHARL HAA , AMJAD K 
Published: May 2024

Gestational diabetes mellitus (GDM) is a prevalent medical complication during pregnancy, associated with adverse maternal and neonatal outcomes. Understanding the impact of GDM on pregnancy complications is essential for effective management and care. Objective: This study aimed to compare the incidence of various complications between pregnant women with and without GDM. Method: A total of 200 pregnant women were recruited from Govt. Sardar Begum Teaching Hospital Sialkot and Civil Hospital Sialkot. These patients were given 75 g oral glucose irrespective of the meals, and their plasma glucose was estimated at two h. Patients with plasma glucose values of 140 mg/dl were labelled GDM; the rest were the control or non-GDM groups. All GDM patients were followed up and treated with diet and insulin therapy till delivery to know maternal and fetal outcomes. Results: Among the enrolled pregnant women, 70 (35%) were diagnosed with GDM. Significant differences were observed between the Non-GDM and GDM groups in terms of Cesarean section delivery (23.8% vs 55.7%, P=0.001), hypertension (13.8% vs 74.3%, P=0.031), and preterm birth (17.7% vs 24.3%, P=0.001). However, no significant difference was found in the incidence of fetal abnormalities between the two groups (9.2% vs. 8.6%, P=0.012). Additionally, the risk of intrauterine fetal demise was comparable between the Non-GDM and GDM groups (10.0% vs. 11.4%, P=0.031). Conclusion: Pregnant women with GDM are at increased risk of Cesarean section delivery, hypertension, and preterm birth compared to those without GDM. However, the incidence of fetal abnormalities and intrauterine fetal demise does not significantly differ between the two groups. Early detection and management of GDM are crucial to minimise adverse pregnancy outcomes.
The Influence of Gut Microbiome Derived Neurotransmitters on Neonatal Immune Response
Authors: Alwazzan Ahmed 
Published: May 2024

The complex interaction between neurotransmitter, gut flora and immune system has expanded dramatically. Infant gut microbiome is a key driver of immune system development [1].Any disruption in gut microbiota during early life have been associated with childhood disorders such as food allergies, neurodevelopmental disorders and asthma[2].The bacteria in guts are not just inert inhabitants of our digestive systems. Their metabolic activities involve the active creation of neurotransmitters such as GABA, dopamine, and serotonin. Gut is known as second brain because it produces 90% of neurotransmitters including dopamine and serotonin [3]. In adults, neurotransmitters are produced by enterochromaffin cells but in infants there is need to unveil the regulation of neurotransmitters. Some of the studies have shown the relationship between gut flora and immune system.
Neonates are more susceptible to diseases because their gut is not mature enough to produce neurotransmitters. Some specific gut microbiome in infants produce serotonin which activates the T-regulatory cells (Tregs). Tregs act as a defence mechanism against autoimmune disorders and food allergic reactions. The number of serotonin producing neonatal gut flora can be influenced by diets, availability of antibiotics and reduce exposure of microbes in their environment. Any change in level of serotonin might affect the development of Tregs. The reason that makes infant more prone to allergic reactions and autoimmune disorders in developed countries.
Scientists are trying to dig out about how gut bacteria in human newborn samples, produce serotonin. This research could lead to the development of effective immune system training techniques, which would lower the lifetime risk of inflammatory illnesses like allergies and inflammatory bowel disease. This work highlights the importance of gut microbes in developing immunity in infancy and provides opportunities for further studies targeted at reducing immune-related illnesses. Interventions that support healthier immune responses from infancy through maturity may be made possible by better understanding and utilizing the power of gut flora.
Perinatal Outcomes of High Risk Pregnancies: Experience of a Tertiary Care Hospital
Authors: Ghaffar Saima , Channa Shahla , Dars Saira , Khan Shafia , Liaquat Farah , Shah Hanozia 
Published: May 2024

High Risk Pregnancy (HRP) denotes a condition where the mother, the fetus, or both are predisposed to complications during the gestation period, at birth, or postnatally, which is affected by several factors. Objective: To analyze the perinatal outcomes of high-risk pregnancies, focusing on the experience of a tertiary care hospital. Methods: A longitudinal study over two years, from October 1, 2020, to December 31, 2022, was conducted on 213 high-risk pregnant women, via purposive sampling, who attended the antenatal clinic Liaquat University Hospital, Hyderabad and Jamshoro. After obtaining informed written consent, interviews were conducted with the participants to collect data about their sociodemographic, obstetric, and gynecological histories. Perinatal outcomes were evaluated on the 8th day post-delivery, during which details concerning maternal and fetal complications in terms of morbidity and mortality, were documented. Results: Rh-negative pregnancy was found to be the most high-risk factor with 24.4% (52) of the cases, followed by teenage pregnancy at 12.2% (26), and short stature at 10.9% (23). Additionally, severe anemia was found in 21 women (9.8%), Pregnancy Induced Hypertension (PIH) in 18 women (8.6%), and obesity was also seen in 18 women (8.6%). Other noted risk factors included grand multigravida in 13 women (6.1%), thyroid disorder 4.9% (10), twin pregnancy 3.7% (8) and congenital fetal anomaly, polyhydramnios, oligohydramnios each with 2.4% (5). Conclusions: This study significantly contributes to the body of knowledge on high-risk pregnancies and their outcomes.
Study on Trajectory Motion of Intra Row Weeder
Authors: K. Raju Yadav  , A. Suredrakumar  , P. Dhananchezhiyan  , Kavitha  , S. D. Sivakumar  , M. R. Duraisamy  
Published: May 2024

Weeding is a critical and labor-intensive process. A mechanical hydraulic actuated weeder was developed by adopting a rotary mechanism that consisted of a rotating blade with the diameter and width of the weeding blade. Instead of lab and field evaluation, the weeding tool's path was traced using the SolidWorks software to reduce cost and time and improve performance and accuracy. A 3D model of the intra-row weeder complex with relative handling modules was analyzed for motion using the SolidWorks Motion system. The blade center moved parallel to the crop row, with the swept area passing between the plant's forming a acycloidal path in rows. Controlled laboratory experiments were conducted to analyze the effects of the weeding blade geometry, forward speed (1, 1.2 and 1.4 km/h), and weeding tool speed (30, 40, 50 and 60 rpm). The results showed that plant damage was much less at a speed of 1.2 km/h and a weeding tool speed of 50 rpm was found to be optimum for effective weeding operation with plant-to-plant spacing of 45 cm in the experimental test rig.
Dermatophytes Isolation from Patients and In-vitro Application of Selected Natural Extracts and Oils for Anti-Dermatophytic Activity
Authors: Akbar Ali , Khan Ghulam Ishaq , Zareen Gul  , Nosheen Akhter  , Haleema Sadia  
Published: May 2024

Dermatophytosis, commonly known as ringworm, is caused by a group of fungi termed dermatophytes. It can invade the keratinized tissue of the skin, nails, and hair. Dermatophytosis is classified based on the site of infection, such as tinea pedis, tinea capitis, and tinea unguium. This study was performed at Bolan Medical College Hospital, Quetta, to isolate and identify the infectious agents of dermatophytes related infections in patients following all the codal formalities and ethical procedures. A total of 19 patients' samples were analyzed in the study, where ten samples were positive for infectious agents. The organisms were grown on specified media, such as dermatophytes test medium agar and potato dextrose agar, supplemented with antibiotics. The isolates were preliminary identified with the help of their growth on specific media and finally confirmed with the help of compound microscopic examination. Some common natural compounds, such as apple peel extract (APE), grapes peduncle extract (GPE), propolis oil (PO), and bitter apricot kernel oil (BAKO), were used against the dermatophytes isolates and were found positive for activity against a few isolates. The APE showed inhibitory activity of 31% against Trichophyton tonsurans and 80% against Epidermophyton flocosum, while the GPE showed 27% and 74%, PO showed 42% and 69%, and BAKO showed 78% and 70% activity against Trichophyton tonsurans and Epidermophyton flocosum, respectively. The bioactive compounds in these extracts were analyzed through Fourier Transformed Infrared Spectroscopy.
Unlocking Chickpea Potential: Zinc and Iron Foliar Treatments for Enhanced Growth and Yield
Authors: Usman Muhammad , Khalid Muhammad Uzair , Soomro Mujahid Ali , Panhwar Sajjad Ali , Panhwar Abdul Rauf , Riaz Usman , Iqbal Hafiz Muhammad Waleed , Haq Ibrar ul 
Published: May 2024

Chickpea is one of the most important crops of Pakistan. In the current study, the effect of five doses of zinc and iron was investigated on the growth and yield of chickpeas. The treatments include basal dose of 33% ZnSO4@25kg/ha, basal dose of 33% ZnSO4 @50kg/ha, foliar application of Zn @1% solution, foliar application of Zn @ 2% solution for zinc while the iron treatments were basal dose of FeSO4 @25kg/ha, basal dose of FeSO4 @50kg/ha, foliar application of Fe @1% solution, foliar application of Fe @ 2% solution. The experiments were conducted during two growing seasons 2022 and 2023. The results indicated that foliar application of 2% zinc resulted in higher plant height (50.77-50.96 cm), more numbers of branches (16.16-16.18), pods per plant (16.71-16.92), numbers of grains per pod (1.81-1.85) and yield (1466.1-1475.5 kg per ha) compared to control and other treatments. Similarly, foliar application of 1% iron caused a significant increase in plant height (49.86-50.20), number of branches (15.97-16.20), pods per plant (16.81-16.91) and yield (933.56-1011.56 kg per ha). Therefore, the application of 2% Zn and 1% Fe is recommended to get a higher yield of chickpea.
Association of UGT1A1 Genetic Variants with Increases in Bilirubin Levels
Authors: Editorial Staff  
Published: May 2024

For patients that are intolerant or resistant to the disease-modifying-antirheumatic-drugs (DMARDS) or suffer from mild to moderate rheumatoid arthritis (RA), a human monoclonal antibody targeting interleukin (IL)-6Rα called Sarilumab is approved for use. Patients who are given Sarilumab are reported to have mild abnormalities in the AST/ALT levels. Lin and colleagues performed a genome-wide investigation into the elevated levels of bilirubin in patients suffering from RA and are being administered Sarilumab. DNA samples of 1075 patients were subjected to exome sequencing and genotyping. Their findings reveal that maximum elevations in bilirubin levels are associated with variants of the UGT1A1 gene (rs4148325; p = 2.88 × 10−41) but ALT/AST elevations harbored no such association. Other independent loci failed to have any associations in Sarilumab prescribed patients having bilirubin elevations. The authors argue that variants of the UGT11 gene are associated with bilirubin increase in RA patients taking Sarilumab. Pharmacogenomics J. 2022 May;22(3):160-165.
Prediction of Toxicities Induced by Sorafenib and Regorafenib
Authors: Editorial Staff  
Published: May 2024

Currently, no biomarkers are available for detecting toxicities induced by the vascular endothelial growth factor (VEGF) tyrosine kinase inhibitors (TKI). Quintanilha and colleagues employed a discovery-validation approach to identify the markers of toxicities induced by these agents. A total of 140 cancer patients treated with Sorafenib (TARGET) were genotyped for 56 single nucleotide polymorphisms (SNPs). A separate cohort of 201 sorafenib-treated patients was tested for associations between grade ≥2 toxicities and the most significant SNPs. Specific SNPs displayed an association with composite toxicities, dermatological toxicities, diarrhea, and grade ≥2 hypertension. The association with grade ≥2 toxicities with the validated SNP was further investigated in 82 (Italian cohort) and 107 (LCCC 1029) patients administered regorafenib. Logistic regressions were employed to elucidate SNP-toxicity associations, followed by a meta-analysis of the conducted research for inverse variance. The results demonstrated that the presence of SNPs in KDR increased the risk of grade ≥2 composite toxicities in TARGET patients. In the Italian cohort, toxicities were associated with the variant rs4864950. Thus, their studies identified a predictor of VEGF TKI-induced toxicities. The Pharmacogenomics Journal (2022) DOI: 10.1038/s41397-022-00279-3.
Anti-TNF-α Treatment Response in Ankylosing Spondylitis Depends on Gut Microbiota
Authors: Editorial Staff  
Published: May 2024

Multiple auto-immune diseases are caused by dysbiosis of the gastrointestinal (GI) tract. One such condition is ankylosing spondylitis which is treated using tumor necrosis factor-alpha (TNF-α) inhibitors. It is well known that normal flora of the GI tract interacts with endogenous TNF-α. Quinghong and associates aimed to investigate the gut microbiome in patients with ankylosing spondylitis that have been administered TNF-α blockers and subsequently identify essential bacteria involved. From 24 ankylosing spondylitis patients and 11 healthy volunteers, fecal samples were analyzed for microbiota profiling using bioinformatic tools and 16S ribosomal DNA amplicons before and after treatment with TNF-α inhibitors. The gut flora profiles of the patients and the healthy controls differed significantly, with a drastically lower amount of short-chain fatty acid (SCFA) producing bacteria observed in the former. Post-anti-TNF α treatment, the patients of ankylosing spondylitis exhibited a positive response where rescue of gut microbiota was seen compared to healthy volunteers. SCFA-producing bacteria- Megamonsa and Lachnoclostridium were significantly lower. Moreover, a negative correlation with disease severity was also observed. Haemophilus and Bacilli, however, may promote disease onset and severity. The investigators, therefore, concluded that gut microbiome, especially SCFA-producing bacteria, can be restored using TNF-α inhibitors in patients suffering from ankylosing spondylitis Pharmacogenet Genomics (2022) DOI: 10.1097/FPC.0000000000000468.
Genetic Variation in OPRK1 Gene and Opioid Use Disorder
Authors: Staff Editorial 
Published: May 2024

The OPRK gene encodes the kappa opioid receptor, which is involved in modulating the effects of opioids in the brain. Polymorphisms in the OPRK1 gene have been investigated for their potential association with opioid use disorder (OUD) and related phenotypes. OUD refers to a problematic pattern of opioid use characterized by a loss of control over use, craving, and negative consequences. To evaluate the association between OPRK1 rs963549 and rs997917 and opioid use disorder (OUD) and related phenotypes, Özkan-Kotiloğlu et al conducted a study.
A sample of 208 individuals with (n = 100) and without (n = 108) OUD were enrolled. OPRK1 rs963549 and rs997917 were analyzed by PCR-RFLP. Craving, opioid withdrawal, and the intensity of depressive and anxiety symptoms were measured by the appropriate scales. OPRK1 rs963549 variation showed a trend of association with decreased opioid withdrawal. No significant associations were found between OPRK1 rs963549 and rs997917 polymorphisms and craving, depression or anxiety symptoms. Neither single OPRK1 SNPs nor OPRK1 haplotypes were associated with OUD. Their results could be useful for treatment failures of individuals who experience greater opioid withdrawal due to their OPRK1 rs963549 genotypes. Pharmacogenomics. 2023 May 11. doi: 10.2217/pgs-2023-0037. Online ahead of print.
Investigation of the Association of GATM Gene Polymorphisms with Statin-Induced Myopathy
Authors: Hussain Arif , Zakria Muhammad , Tariq Shafiq Ahmed , Abdul Rauf Muhammad , Ahmad Jamil , Fawad Rasool Muhammad , Ali Iftikhar 
Published: May 2024

Statins are one of the mainstay medicines for treating hyperlipidemia. The effect of statins can extend beyond their direct role in cholesterol transport to anti-inflammatory and plaque stabilization in coronary artery disease (CAD). Statins are known to reduce low-density lipoproteins (LDL) by up to 55%, which can inadvertently reduce the risk of cardiac events in patients. Strong clinical profile notwithstanding, statins are notorious for their muscle-related adverse effects. Some variations in genes such as glycine amidinotransferase (GATM) have been implicated in this side effect; however, the reports are not all congruent. In the current study, a prospective cohort design was used to establish both drug efficacy and the incidence of muscle-rated adverse reactions in patients receiving atorvastatin and rosuvastatin. The muscle adverse effects were recorded using the “Statin Associated Muscle Symptoms-Clinical Index” (SAMS-CI) tool. Drug plasma levels were recorded using LC-MS, and GATM rs9806699 was genotype using direct Sanger sequencing. A binary logistic model was used to determine the association between genotypes and the incidence of muscle symptoms, whereas stepwise linear regression was used to determine the association between plasma concentration, genetics, and muscle symptoms. Among 130 enrolled patients, 97(74.62%) received rosuvastatin 10 mg (once daily), and 33 (25.38%) received atorvastatin 20 mg (once daily). A total of 26 patients reported adverse drug reactions according to the SAMS-CI. The genotype frequency of GATM rs9806699-GG was 45.74%, whereas the heterozygous genotype (AG) was 34(36.17%), and the AA genotype was 18.09%. There was no significant difference found between the plasma concentrations of both rosuvastatin and atorvastatin among GATM rs9806699 genotypes. Despite the high incidence of muscular adverse effects, there was no significant association between GATM genotypes and SAMS.