bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pitfalls and possibilities of using Root SedLine for continuous assessment of EEG waveform-based metrics in intensive care research
Authors: Bögli Stefan Yu , Cherchi Marina Sandra , Olakorede Ihsane , Lavinio Andrea , Beqiri Erta , Moyer Ethan , Moberg Dick , Smielewski Peter 
Published: May 2024

Abstract

Objective. The Root SedLine device is used for continuous electroencephalography (cEEG)-based sedation monitoring in intensive care patients. The cEEG traces can be collected for further processing and calculation of relevant metrics not already provided. Depending on the device settings during acquisition, the acquired traces may be distorted by max/min value cropping or high digitization errors. We aimed to systematically assess the impact of these distortions on metrics used for clinical research in the field of neuromonitoring. Approach. A 16 h cEEG acquired using the Root SedLine device at the optimal screen settings was analyzed. Cropping and digitization error effects were simulated by consecutive reduction of the maximum cEEG amplitude by 2 µV or by reducing the vertical resolution. Metrics were calculated within ICM+ using minute-by-minute data, including the total power, alpha delta ratio (ADR), and 95% spectral edge frequency. Data were analyzed by creating violin- or box-plots. Main Results. Cropping led to a continuous reduction in total and band power, leading to corresponding changes in variability thereof. The relative power and ADR were less affected. Changes in resolution led to relevant changes. While the total power and power of low frequencies were rather stable, the power of higher frequencies increased with reducing resolution. Significance. Care must be taken when acquiring and analyzing cEEG waveforms from Root SedLine for clinical research. To retrieve good quality metrics, the screen settings must be kept within the central vertical scale, while pre-processing techniques must be applied to exclude unacceptable periods.
Photoinduced Floquet higher-order Weyl semimetal in C6 symmetric Dirac semimetals
Authors: Xu 许 Xin-Xin 欣欣 , Wang 王 Zi-Ming 梓名 , Xu 许 Dong-Hui 东辉 , Chen 陈 Chui-Zhen 垂针 
Published: May 2024

Abstract
Topological Dirac semimetals are a parent state from which other exotic topological phases of matter, such as Weyl semimetals and topological insulators, can emerge. In this study, we investigate a Dirac semimetal possessing sixfold rotational symmetry and hosting higher-order topological hinge Fermi arc states, which is irradiated by circularly polarized light. Our findings reveal that circularly polarized light splits each Dirac node into a pair of Weyl nodes due to the breaking of time-reversal symmetry, resulting in the realization of the Weyl semimetal phase. This Weyl semimetal phase exhibits rich boundary states, including two-dimensional surface Fermi arc states and hinge Fermi arc states confined to six hinges. Furthermore, by adjusting the incident direction of the circularly polarized light, we can control the degree of tilt of the resulting Weyl cones, enabling the realization of different types of Weyl semimetals.
Review on automated 2D material design
Authors: Al-Maeeni Abdalaziz , Lazarev Mikhail , Kazeev Nikita , Novoselov Kostya S , Ustyuzhanin Andrey 
Published: May 2024

Abstract
Deep learning (DL) methodologies have led to significant advancements in various domains, facilitating intricate data analysis and enhancing predictive accuracy and data generation quality through complex algorithms. In materials science, the extensive computational demands associated with high-throughput screening techniques such as density functional theory, coupled with limitations in laboratory production, present substantial challenges for material research. DL techniques are poised to alleviate these challenges by reducing the computational costs of simulating material properties and by generating novel materials with desired attributes. This comprehensive review document explores the current state of DL applications in materials design, with a particular emphasis on two-dimensional materials. The article encompasses an in-depth exploration of data-driven approaches in both forward and inverse design within the realm of materials science.
Defect-induced modifications in electronic and thermoelectric properties of pentagonal PdX2 (X = Se, S) monolayers
Authors: Sharma Mridu , Nag Shagun , Kumar Ranjan , Singh Ranber 
Published: May 2024

Abstract
The point defects induced in crystalline solids during the growth process unintentionally or doped intentionally after the growth process significantly modify their properties. The intentionally controlled doping of point defects in crystalline solids has been widely used to tune their properties. In this paper, we investigate the effect of vacancy and substitutional point defects on the electronic and thermoelectric properties of pentagonal PdX2 (X = Se, S) monolayers using the density functional theory (DFT) and semi-classical Boltzmann transport theory. We find that the point defects in pentagonal PdX2 (X = Se, S) monolayers modify their electronic structures. The contributions of d orbitals of Pd atoms and p orbitals of Se/S atoms are significantly affected due to the presence of point defects in the lattice. The defect states are appeared within the band gap region which effectively reduces the band gap of the monolayer. These defect states could be helpful in tuning the electrical and optical properties of the monolayer. The defect states appear within the band gaps of defective monolayer structures which effectively modifies the electronic properties of these monolayer structures. The transport calculations show that the presence of the point defects in the lattice reduces the thermoelectric performance of these PdX2 monolayers. Both the Seebeck coefficient and electrical conductivity show deteriorated behaviour under the influence of point defects in the lattice. Thus, the influence of these defects must be carefully taken into account while fabricating these materials for practical applications.
Material selection for milling fixture of friction stir welding using simulia
Authors: Pandav Appasaheb N , Patil Ratan A , Pandipati Suman 
Published: May 2024

Abstract
Friction stir welding is an innovative welding technique that joins two different materials without the need for consumables. The process involves a profiled probe and shoulder tool that is rotated and plunged between the two workpieces at the interface during the friction stir process. The weld zone undergoes dynamic recrystallization, resulting in a strong bond between the materials. This method offers superior bonding compared to traditional arc welding. In the context of conventional or non-traditional milling machines, friction stir welding is performed. It is necessary to use a milling fixture to attach the plates that need to be butt and lap welded, fixture can be used in underwater FSW. To ensure the workpiece is securely held in place, a fixture or holder is necessary. In this article, friction-stir welding, and a fixture with a clamping setup are constructed. The fixture is carefully designed to consider the movement of the instrument and workpiece, and it is manufactured using CatiaV6 3D experience software. The fixture is then subjected to three different types of testing using Simulia software. The materials tested include cast iron, die steel, and tool steel. After simulation analysis, the best material for friction-stir welding operations is selected.
Gram-scale approach for β-costic acid via allylic oxidation of β-selinene
Authors: Matsushima Yoshitaka , Iwata Kosuke 
Published: May 2024

ABSTRACT
β-Costic acid is a sesquiterpene phytoalexin with acaricidal activity against Varroa destructor and antitrypanosomal activity. A concise and efficient method was developed for the synthesis of β-costic acid via the allylic oxidation of β-selinene, a component of celery seed oil.
Malus toringoides(Rehd.) Hughes decoction alleviates isoproterenol-induced cardiac fibrosis by inhibiting cardiomyocyte inflammation and pyroptosis via the HK1/NLRP3 signaling pathway
Authors: Du Huiru , Zhang Yuling , Guo Haochuan , Cheng Xizhen , Tian Haolin , Wang Yanan , Wang Hongfang , Song Yongxing , Duan Xuhong , Ma Donglai 
Published: May 2024

ABSTRACTMalus toringoides (Rehd.) Hughes, called “Eseye (Ese),” is a traditional medicinal plant from the Tibet province of China that has proven effective in treating cardiac conditions due to its anti-inflammatory, antioxidative, and antiapoptotic properties. In this study, we explored the underlying protective mechanisms of Ese decoction in isoproterenol (ISO)-induced cardiac fibrosis (CF) and established the fact that treatment with an Ese decoction attenuated tissue injury, decreased the release of IL-1β, IL-18, TNF-α, and caspase-3, and elevated the Bax/Bcl-2 ratio in CF mice. We also found that with Ese treatment damage to the mitochondrial ultrastructure of myocardium was alleviated, and the level of reactive oxygen species was markedly diminished. Ese inhibited the expression of proteins associated with pyroptosis by the HK1/NLRP3 signaling pathway and also improved CF. Due to the anti-inflammatory, antioxidative, and antiapoptotic characteristics of Ese decoction, we found that Ese protected against ISO-induced CF, by inhibiting inflammation and pyroptosis as mediated by the HK1/NLRP3 signaling pathway.
Immune profiling reveals umbilical cord blood mononuclear cells from South India display an IL-8 dominant, CXCL-10 deficient polyfunctional monocyte response to pathogen-associated molecular patterns that is distinct from adult blood cells
Authors: Adiga Vasista , Bindhu Hima , Ahmed Asma , Chetan Kumar Nirutha , Tripathi Himanshu , D’Souza George , Dias Mary , Shivalingaiah Sudarshan , Rao Srishti , K N Shanti , Hawrylowicz Catherine , Dwarkanath Pratibha , Vyakarnam Annapurna 
Published: May 2024

Abstract
Neonate responses to pathogen-associated molecular patterns (PAMPS) differ from adults; such understanding is poor in Indian neonates, despite recognized significant infectious risk. Immune profiling analysis was undertaken of 10 secreted mediators contextualized with cellular source induced by six PAMPs in umbilical cord (CB; n = 21) and adult-blood (PBMC; n = 14) from a tertiary care hospital in South India. Differential cytokine expression analysis (minimum log2-fold difference; adj P-value &lt; 0.05) identified bacterial PAMPs induced higher concentrations of IL-1β, IL-10, TNF-α in adults versus IL-8, GM-CSF, IFN-γ, and IL-2 in CB. CB responded to poly I:C and SARS-CoV-2 lysate with a dominant IL-8 response, whereas in PBMC, CXCL-10 dominated poly I:C, but not SARS-CoV-2, responses, highlighting potential IL-8 importance, in the absence of Type I Interferons, in antiviral CB immunity. Candida albicans was the only PAMP to uniformly induce higher secretion of effectors in CB. The predominant source of IL-8/IL-6/TNF-α/IL-1β in both CB and PBMC was polyfunctional monocytes and IFN-γ/IL-2/IL-17 from innate lymphocytes. Correlation matrix analyses revealed IL-8 to be the most differentially regulated, correlating positively in CB versus negatively in PBMC with IL-6, GM-CSF, IFN-γ, IL-2, consistent with more negatively regulated cytokine modules in adults, potentially linked to higher anti-inflammatory IL-10. Cord and adult blood from India respond robustly to PAMPs with unique effector combinations. These data provide a strong foundation to monitor, explore, mechanisms that regulate such immunity during the life course, an area of significant global health importance given infection-related infant mortality incidence.
Pulmonary vascular stenosis scoring in fibrosing mediastinitis
Authors: Wang Yangyang , Bu Chao , Zhang Mengdi , Wang Juan , Jiang Kaiyu , Ding Mingwang , Su Hongling , Long Xiaozhou , Jia Mengfei , Li Yu , Cao Yunshan 
Published: May 2024

Abstract

Aims
This study aims to develop a scoring system for evaluating the degree of pulmonary vascular stenosis in fibrosing mediastinitis (FM).

Methods and results
A retrospective single-centre study was conducted on 56 patients with FM in China between April 2014 and August 2021. The involvement of pulmonary vessels in patients with FM was assessed using dual-phase computed tomography pulmonary angiography, and we found that 85.7% of the patients had both pulmonary artery (PA) and vein (PV) involvement. PA involvement was mainly located proximal to both the upper PA and the bilateral basal trunk levels in the lower lungs. The involvement of the superior PV was more common than that of the inferior PV, and the right inferior PV was the least involved. Most of these lesions exhibited moderate or severe stenosis. Additionally, a scoring system for evaluating the degree of pulmonary vascular stenosis was developed. A correlation analysis revealed a negative correlation between the final pulmonary vascular score and the pulmonary arterial pressure, pulmonary vascular resistance, and maximum tricuspid regurgitation velocity. The calculated score of 17.1 was the best cut-off value for the diagnosis of mild and severe pulmonary hypertension (PH).

Conclusion
We successfully developed a scoring system for pulmonary vascular stenosis that can be used to evaluate the severity of pulmonary vessel involvement and PH. This scoring system may be relevant in the future development of target-based strategies for percutaneous interventions.
Food Is Medicine for Human Immunodeficiency Virus: Improved Health and Hospitalizations in the Changing Health Through Food Support (CHEFS-HIV) Pragmatic Randomized Trial
Authors: Palar Kartika , Sheira Lila A , Frongillo Edward A , O’Donnell Asher A , Nápoles Tessa M , Ryle Mark , Pitchford Simon , Madsen Kim , Phillips Beth , Riley Elise D , Weiser Sheri D 
Published: May 2024

Abstract

Background
Policy support for “food is medicine”—medically tailored meals or groceries to improve health—is rapidly growing. No randomized trials have heretofore investigated the benefits of medically tailored food programs for people with human immunodeficiency virus (PWH).

Methods
The CHEFS-HIV pragmatic randomized trial included PWH who were clients of Project Open Hand (POH), a San Francisco–based nonprofit food organization. The intervention arm (n = 93) received comprehensive medically tailored meals, groceries, and nutritional education. Control participants (n = 98) received less intensive (POH “standard of care”) food services. Health, nutrition, and behavioral outcomes were assessed at baseline and 6 months later. Primary outcomes measured were viral nonsuppression and health-related quality of life. Mixed models estimated treatment effects as differences-in-differences between arms.

Results
The intervention arm had lower odds of hospitalization (odds ratio [OR], 0.11), food insecurity (OR, 0.23), depressive symptoms (OR, 0.32), antiretroviral therapy adherence &lt;90% (OR, 0.18), and unprotected sex (OR, 0.18), as well as less fatty food consumption (β = −.170 servings/day) over 6 months, compared to the control arm. There was no difference between study arms in viral nonsuppression and health-related quality of life over 6 months.

Conclusions
A “food is medicine” intervention reduced hospitalizations and improved mental and physical health among PWH, despite no impact on viral suppression.

Clinical Trials Registration
NCT03191253.
Escherichia coli isolated from pyometra and cystitis in the same animal exhibit a wide phenotypic similarity
Authors: Moni Camila Azevedo , Dias Maria Eduarda , Lopes Cassiane Elisabete , Siqueira Franciele Maboni 
Published: May 2024

Abstract

Aims
Pyometra and cystitis caused by Escherichia coli are common diseases identified in canine or feline females. The origin of pyometra infection remains uncertain, and effective prevention strategies for this disease are still unknown. This study aimed to provide a phenotypic characterization, including antimicrobial resistance and virulence profiles, of endometrial pathogenic (EnPEC) and uropathogenic (UPEC) E. coli strains isolated simultaneously from the same animal.

Methods and results
Sixteen E. coli strains, from eight different animals, were analyzed in this study. The antimicrobial susceptibility profile of EnPEC and UPEC strains was determined using the disc diffusion method, which showed a similar susceptibility profile among strains (EnPEC and UPEC) from the same animal. The virulence profile of the strains was assessed through biofilm formation, as well as serum resistance abilities. EnPEC and UPEC strains from the same animal exhibited slight variations in their virulence and antimicrobial resistance capabilities. Overall, most of the strain pairs showed a high similarity in their ability to establish biofilms and survive in serum complement activity.

Conclusions
Overall, strains of E. coli isolated from both pyometra and cystitis in the same animal, despite presenting distinct clinical diseases, exhibit a wide phenotypic similarity, suggesting a common origin for the strains.
Venom-microbiomics of eight species of Neotropical spiders from the Theraphosidae family
Authors: Viquez Carlos , Rojas-Gätjens Diego , Mesén-Porras Esteve , Avendaño Roberto , Sasa Mahmood , Lomonte Bruno , Chavarría Max 
Published: May 2024

Abstract

Aim
Tarantulas are one of the largest predatory arthropods in tropical regions. Tarantulas though not lethal to humans, their venomous bite kills small animals and insect upon which they prey. To understand the abiotic and biotic components involved in Neotropical tarantula bites, we conducted a venom-microbiomics study in eight species from Costa Rica.

Methods and results
We determined that the toxin profiles of tarantula venom are highly diverse using shotgun proteomics; the most frequently encountered toxins were ω-Ap2 toxin, neprilysin-1, and several teraphotoxins. Through culture-independent and culture-dependent methods, we determined the microbiota present in the venom and excreta to evaluate the presence of pathogens that could contribute to primary infections in animals, including humans. The presence of opportunistic pathogens with hemolytic activity was observed, with a prominence of Stenotrophomonas in the venoms. Other bacteria found in venoms and excreta with hemolytic activity included members of the genera Serratia, Bacillus, Acinetobacter, Microbacterium, and Morganella.

Conclusions
Our data shed light on the venom- and gut-microbiome associated with Neotropical tarantulas. This information may be useful for treating bites from these arthropods in both humans and farm animals, while also providing insight into the toxins and biodiversity of this little-explored microenvironment.
A statistical approach to Hollywood remake and sequel metadata
Authors: Hołobut Agata , Rybicki Jan , Stelmach Miłosz 
Published: May 2024

Abstract
Hollywood film remakes, as old as the cinema itself, have attracted much professional, critical, and academic attention. They have been viewed by art critics as products of cultural derivativity and imperialism and commended by financial experts as low-risk business investments, closely linked to other forms of brand extension, such as sequels and bestseller adaptations. In this article, we adopt a film-historical quantitative approach to Hollywood film remakes by analysing metadata obtained from the Internet Movie Database (IMDb) and verified against reliable print and web sources. We analyse 986 Hollywood remakes produced between 1915 and 2020 in terms of raw and relative frequencies of annual releases, genre (in)stability, and patterns of transnational reproduction. We contrast our findings with those outlined by Henderson (2014a) in his statistical survey of Hollywood sequels, series films, prequels, and spin-offs, presented in his monograph The Hollywood Sequel: History and Form, 1911–2010. Having completed his list with recent sequential productions released between 2011 and 2020, we investigate the potential parallels between Hollywood remaking and sequelization practices. Our findings demonstrate historical discrepancies in various ‘content recycling’ trends, which help better characterize the cultural and commercial significance of remakes and serial forms in the American film industry.
Widespread Misperceptions Among U.S. Adults About Tobacco Company Engagement in Black and African American Communities
Authors: Sterling Kymberle L , Ganz Ollie , Wackowski Olivia A , Glasser Allison M , Villanti Andrea C 
Published: May 2024

AbstractIntroductionMenthol cigarettes and flavored cigars (MC/FC) bring profits to U.S. tobacco companies at the cost of Black/African American (B/AA) lives. This exploratory cross-sectional study describes perceptions of tobacco company engagement and activities in B/AA communities related to MC/FC.Aims and MethodsAmong 2307 U.S. adults aged 18–45 surveyed in 2022, six items addressed beliefs about tobacco company funding of B/AA community organizations, payment of B/AA lobbyists to oppose public health policies, support of health equity efforts in B/AA communities, and targeted marketing of MC/FC in B/AA communities. Adjusted proportions were calculated for each belief overall and by race and cigarette smoking status.ResultsAmong all adults, 37% believed that tobacco companies deny the harms of MC/FCs, 20% believed they pay Black lobbyists to oppose health policies, and 12% believed they fund Black community organizations. Compared with non-B/AA adults, a higher proportion of B/AA adults believed that tobacco companies target Black communities with MC/FC marketing (62% vs. 46%). More adult smokers (ie, menthol or non-MC) than nonsmokers thought that tobacco companies support health equity efforts and did not target Black communities with MC/FC marketing nor deny the harms of MC/FCs to B/AA communities.ConclusionsFew B/AAs and adult smokers believed that tobacco companies used B/AA organizations and lobbyists to oppose MC/FC policies in the B/AA community as well as reject MC/FC’s harmfulness. Culturally tailored and community-engaged communication efforts are needed to correct disinformation about MC/FC tobacco companies’ engagement and activities in B/AA communities among B/AA and menthol cigarette smokers.ImplicationsTobacco companies have a history of predatory marketing that promotes flavored tobacco products to Black/African American (B/AA) individuals and more recently has spread disinformation to dissuade policy support for menthol cigarette/flavored cigar (MC/FC) bans. It is unclear what are the perceptions of tobacco company engagement and activities in B/AA communities related to MC/FC. Our study shows that B/AA adults and current cigarette smokers hold misperceptions about tobacco companies’ role in spreading disinformation about MC/FC. This study identified beliefs about the industry’s role in funding B/AA organizations and lobbyists who oppose policy, as well as the industry’s denial of menthol cigarette and flavored cigar harms as potential messaging targets for communication efforts designed to correct disinformation about MC/FC policies among B/AA and those who currently smoke MC.
Hepatitis C Virus Clearance and Diffusing Capacity for Carbon Monoxide in Women With and Without Human Immunodeficiency Virus
Authors: Curnow Andrew C , Huang Laurence , Fischl Margaret A , Floris-Moore Michelle , Morris Alison , Nouraie Mehdi , Reddy Divya B , Seaberg Eric C , Sheth Anandi N , Tien Phyllis C , Wang Richard J 
Published: May 2024

Abstract
Hepatitis C virus (HCV) infection is associated with extrahepatic effects, including reduced diffusing capacity of the lungs. It is unknown whether clearance of HCV infection is associated with improved diffusing capacity. In this sample of women with and without human immunodeficiency virus, there was no association between HCV clearance and diffusing capacity.