bluuebunny/crossref_metadata_2025_split huggingface dataset:
Robot-Assisted Resection of Exposed Colon With TaTME After Heavy Ion Radiotherapy for Locally Recurrent Rectal Cancer: A Case Report
Authors: Naito Atsushi , Takahashi Hidekazu , Iwamoto Kazuya , Matsuda Chu , Nishikawa Kazuhiro , Mizushima Tsunekazu 
Published: June 2024

Introduction
Heavy ion radiotherapy has shown promising results in treating pelvic recurrence of rectal cancer. We report a case in which a patient underwent robot-assisted low anterior resection with transanal mesorectal excision (TaTME) following heavy ion radiotherapy, owing to challenges associated with spacer placement.

Case presentation
A 54-year-old man was diagnosed with upper rectal cancer. He underwent robot-assisted low anterior resection. Eight courses of CapeOX were administered as postoperative adjuvant chemotherapy. Immediately after completion of adjuvant chemotherapy (8 months postoperatively), computed tomography (CT) scan revealed a 30-mm large nodule on the dorsal surface of the oral anastomotic intestine, which was detected by positron emission tomography–CT. Given that the tumor had an indistinct border with the sacrum and its superior margin extended to the second sacrum, it was concluded that a combined sacral resection was not advisable, and heavy ion radiotherapy was indicated. Robot-assisted low anterior resection combined with TaTME was performed approximately 2 months after heavy particle radiotherapy [73.6 Gy (relative biological effectiveness)/16 sessions]. CT scan conducted 3 months after irradiation revealed substantial shrinkage of the recurrent tumor.

Conclusion
Robot-assisted resection of exposed colon with TaTME after heavy ion radiotherapy is regarded as an effective strategy for treating locally recurrent rectal cancer.
Pharmacologic management of adolescent catatonia: A dual-case series
Authors: Leiby Lauren , Shiplett Lauryn , Lin Wendy , Dick Matthew , Thornton Hannah 
Published: June 2024

Introduction
Catatonia is a syndrome characterized by psychomotor and behavioral disturbances and is associated with a substantially increased mortality risk in adolescent patients. There is a dearth of published literature describing treatment strategies for pediatric patients with catatonia. This dual-case series will describe the treatment course of 2 adolescent patients with catatonia at our pediatric inpatient psychiatric facility.

Case Series
This case series presents 2 adolescent patients (a 17-year-old male and a 16-year-old female) who initially presented with worsening agitation and paranoia, later developing catatonia. Both patients required long durations of hospitalization and were treated with high-dose lorazepam before requiring the addition of electroconvulsive therapy (ECT).

Discussion
Treatment of pediatric patients with catatonia creates a significant burden on patients, families, and the healthcare system. Treatment with high-dose benzodiazepines is high risk, while ECT is both difficult to access and comes with its own risks. Both patients discussed are transitional age, meaning they will soon be young adults who will continue to require high-level psychiatric care. Psychiatric pharmacists have a large role to play in ensuring safe medication management for these complex patients.

Conclusions
This case series of 2 adolescent patients with catatonia demonstrates marginal reduction in symptoms with high-dose lorazepam in conjunction with ECT, with minimal side effects. This case series adds to the limited available literature regarding treatment of catatonia in pediatric patients and highlights the need for further study into effective treatment alternatives.
The potential influence of estrogen-containing oral contraception on clozapine metabolism in a patient with known pharmacogenomic status
Authors: Kuhn Alyssa K. , Determan Meina L. , Wright Jessica A. , Matey Eric , Leung Jonathan G. 
Published: June 2024

Abstract
Clozapine is primarily metabolized via cytochrome P450(CYP)1A2 and to a lesser extent CYP3A4, CYP2C19, and CYP2D6. Metabolic inhibitors of clozapine, such as fluvoxamine and ciprofloxacin, are important to recognize to avoid adverse drug events. Estrogen-containing oral contraceptives (eOCPs) are weaker CYP1A2 and CYP2C19 inhibitors but are associated with a 2-fold increase of clozapine concentrations. The potential for phenoconversion due to a CYP genetic polymorphism can add additional complexities when considering drug interactions. A case report is presented of a suspected interaction between newly initiated clozapine and a prescribed eOCP for which the patient’s pharmacogenomic status was known. A 17-year-old, nonsmoking, White female with a history of schizophrenia was initiated on clozapine 12.5 mg at bedtime with a plan to increase by 25 mg every 4 days in the outpatient setting. The patient was a known rapid CYP1A2 metabolizer without identified sources of CYP1A2 induction and a CYP2C19 rapid metabolizer. Based on pharmacogenomic testing, there was no suspicion for significant gene-drug interactions. Yet, as the patient was prescribed an eOCP, a clozapine concentration was obtained after reaching 150 mg at bedtime. This steady-state clozapine concentration was found to be 560 ng/mL, correlating with worsening sedation and constipation. Given ongoing side effects, clozapine was lowered to 100 mg at bedtime; however, ongoing intolerance ultimately led to clozapine discontinuation. This case highlights the potential interaction between clozapine and eOCP in a CYP1A2 and CYP2C19 rapid metabolizer, leading to clozapine intolerance and discontinuation. The concomitant use of clozapine and eOCPs should be undertaken judiciously.
Overpredicting and Underprofiting in Pricing Decisions
Authors: Shen Luxi , Hsee Christopher K. , Wu Qingsheng , Tsai Claire I. 
Published: August 2011

ABSTRACTThis research examines sellers' price‐setting behavior and discovers a naturally occurring mismatch between sellers and buyers: Sellers who make a price decision often consider alternative prices and engage in the joint evaluation mode, whereas buyers who make a purchase decision see only the finally set price and are in the single evaluation mode. This mismatch in evaluation modes leads sellers to overpredict buyers' price sensitivity and underprice their products. However, these effects apply only to products unfamiliar to buyers and without salient reference prices and can be alleviated if sellers are encouraged to mimic single evaluation when making pricing decisions. These propositions are empirically tested and verified. Copyright © 2011 John Wiley & Sons, Ltd.
Government responses to the impact of the global crisis on finance for young and small enterprises
Authors: Potter Jonathan , Thompson John 
Published: August 2011

AbstractGovernments responded appropriately to a tightening of access to entrepreneurial finance during the global financial and economic crisis by introducing new and expanded programs focused on loans and loan guarantees, export facilitation and credit mediation, but attention now needs to shift to meeting structural small and medium‐sized enterprise (SME) and entrepreneurship finance challenges in the recovery.
Financial constraints, human and social capital, and risk‐taking attitude in the foundation of new firms
Authors: Fourati Hedia , Affes Habib 
Published: August 2011

AbstractFinancial capital plays an important role in firm creation for the more rich entrepreneurs and risk‐taking attitude predicts new ventures for the entrepreneurs in the median of wealth distribution, but appropriate human capital and age of the entrepreneurs are critical in the case of new business creation.
An exploratory examination of the social capital and FDI linkage and the moderating role of regulatory quality: A cross‐country study
Authors: Zhao Hongxin , Kim Seung H. 
Published: August 2011

AbstractDespite the urge for broader macro‐level examinations of the distinct social constructions within which economic activities take place, numerous national‐level studies of the determinants of foreign‐invested firms have paid little attention to the roles played by social capital and its contingent value in affecting foreign direct investment (FDI) inflows. Drawing on the logic of social capital and institutional theory, this article seeks to offer a complementary, rather than a substitutional, explanation of FDI by examining empirically the national‐level impacts of social capital (trust and associative activity) on FDI and the moderating role of regulatory quality in this relationship. Based on the data of 165 country series from the World Value Survey and the World Bank, our analytical results supported the hypotheses that the rich endowments of social capital positively contributed to the attraction of FDI and such effects are also contingent on the regulatory quality that further strengthened such relationships. These findings also suggest strong implications for managers implementing an FDI and market entry strategy. © 2011 Wiley Periodicals, Inc.
Interaction effects of globalization and institutional forces on international HRM practice: Illuminating the convergence‐divergence debate
Authors: Paik Yongsun , Chow Irene Hau‐Siu , Vance Charles M. 
Published: August 2011

AbstractIn the face of globalization, scholars continue to debate about whether a convergence in human resources practices will prevail, or a trend of divergence perspective will persist. Building on institution theory, this article helps to explicate this debate by examining how globalization may interact with different dimensions of local institutional forces to lead to convergence, divergence, or crossvergence in international HRM practices for enhanced performance. We also present useful propositions for guiding future empirical research and theory development on the interaction between globalization and different forms of local institutional forces, which in turn influence the formation of successful international HRM practices. © 2011 Wiley Periodicals, Inc.
Socio‐economic burden of patients with a diagnosis related to chronic pain – Register data of 840,000Swedish patients
Authors: Gustavsson A. , Bjorkman J. , Ljungcrantz C. , Rhodin A. , Rivano‐Fischer M. , Sjolund K.‐F. , Mannheimer C. 
Published: August 2011

AbstractBackgroundChronic pain constitutes a substantial socio‐economic challenge but little is known about its actual cost.AimTo estimate the direct and indirect costs of patients with a diagnosis related to chronic pain (DRCP), to determine variation in these costs across different diagnosis groups, and to identify what resources constitute the most important components of costs.MethodsPatient level data from three administrative registries in Västra Götalandsregionen in Sweden including inpatient and outpatient care, prescriptions, long‐term sick‐leaves, and early retirement were extracted. Patients with aDRCPbetween January 2004 and November 2009 were selected.ResultsIn total, 840,000 patients with aDRCPwere identified. The mean total costs per patient and year were estimated at 6400EURbut were higher for patients with cancer (10,400EUR). Patients on analgesic drugs had more than twice as high costs as patients without analgesic drugs, on average. Indirect costs (sick‐leaves and early retirement) constituted the largest cost component (59%) followed by outpatient (21%) and inpatient care (14%), whereas analgesic drug prescriptions constituted less than 1 percent of the total.ConclusionsThe socio‐economic burden of patients with a diagnosis related to chronic pain amounts to 32 billionEURper year, when findings from Västra Götalandsregionen are extrapolated to the whole ofSweden. This compares to a fifth of the total Swedish tax burden in 2007 or about a tenth of SwedishGDP. This study does not provide evidence on what costs are caused by chronic pain per se. However, the higher costs of patients on analgesic drugs might indicate that the consequences of pain are of major importance.
Intrathecal administration of NTS1 agonists reverses nociceptive behaviors in a rat model of neuropathic pain
Authors: Guillemette A. , Dansereau M.A. , Beaudet N. , Richelson E. , Sarret P. 
Published: August 2011

AbstractChronic neuropathic pain arising from peripheral nerve damage is a severe clinical issue where there is a major unmet medical need. We previously demonstrated that both neurotensin (NT) receptor subtypes 1 (NTS1) and 2 (NTS2) are involved in mediating the naloxone‐insensitive antinociceptive effects of neurotensin in different analgesic tests including hotplate, tail‐flick, and tonic pain. However, the role of these receptors in neuropathic pain management has been poorly investigated. In the present study, we therefore examined whether intrathecal delivery of NTS1 agonists was effective in reducing neuropathic pain symptoms in rats. Neuropathy was induced by sciatic nerve constriction (CCI model), and the development of mechanical allodynia and thermal hyperalgesia on the ipsi‐ and contralateral hind paws was examined 3, 7, 14, 21, and 28 days post‐surgery. CCI‐operated rats exhibited significant increases in thermal and mechanical hypersensitivities over a 28‐day testing period. Spinal injection of NT to CCI rats alleviated the behavioral responses to radiant heat and mechanical stimuli, with a maximal reversal of 91% of allodynia at 6 μg/kg. Intrathecal administration of the NTS1‐selective agonist, PD149163 (30–90 μg/kg) also produced potent anti‐allodynic and anti‐hyperalgesic effects in nerve‐injured rats. Likewise, heat hyperalgesia and tactile allodynia produced by CCI of the sciatic nerve were fully reversed by the NTS1 agonist, NT69L (5–25 μg/kg). Altogether, these results support the idea that the NTS1 receptor subtype is involved in pain modulation, and the potential use of NTS1 agonists for the treatment of painful neuropathies.
The effect of validating and invalidating communication on satisfaction, pain and affect in nurses suffering from low back pain during a semi‐structured interview
Authors: Vangronsveld K.L. , Linton S.J. 
Published: August 2011

AbstractWhen physicians interview patients with ambiguous or nonspecific symptoms, they often try to reassure them with the purpose of explaining that no dangerous illness or disease is causing the symptoms. Unfortunately the evidence suggests that patients with benign (back) pain instead feel misunderstood, frustrated and unsatisfied with the consultation. Validation is a communication method that focuses on understanding and empathy as a platform for problem solving and it may be applicable for interviews in medical settings. The aim of this study was to examine the effects of validation on patient satisfaction, pain and affect.To this end 28 nurses with (re)current back pain were recruited and randomly assigned to be interviewed in a validating or invalidating condition. Patient satisfaction, affect, pain, disability, pain catastrophizing, and fear of movement were assessed immediately after the interview.The results show that the participants in the validated group were more satisfied with the interview than participants in the invalidating condition. Moreover, they showed a significant decrease on all measures of negative affect as well as for pain. For example, there was a significant between group difference in frustration where frustration decreased in the validation group, while it increased in the invalidation condition.A validating communication style seems to be beneficial for enhancing patient satisfaction, as well as diminishing negative affect and pain intensity ratings. Our results suggest that validation might be a viable technique to use in clinical examinations of patients suffering pain.
Effects of perceived and exerted pain control on neural activity during pain relief in experimental heat hyperalgesia: A fMRI study
Authors: Mohr C. , Leyendecker S. , Petersen D. , Helmchen C. 
Published: August 2011

AbstractPerceived control over pain can attenuate pain perception by mechanisms of endogenous pain control and emotional reappraisal irrespective of whether this control is exerted or only perceived. Self‐initiated termination of pain elicits different expectations of subsequent pain relief as compared to perceived pain control. It is unknown whether and how this perceived vs. exerted control on pain differs and affects subsequent pain relief. Using fMRI, we studied two factors of pain control on pain relief: the (i) sense of control (perceived control but no execution) and (ii) the execution of control (exerted control). To account for the impact of factual execution of pain control on pain relief we applied bearable short and hardly bearable long contact‐heat stimuli which were applied either controllable or not. Using controllability as factor, there was dissociable neural activity during pain relief: following the perceived control condition neural activity was found in the orbitofrontal and mediofrontal cortex and, following the exerted control condition, in the anterolateral and dorsolateral prefrontal cortex and posterior parietal cortex.We conclude that (i) pain controllability has an impact on pain relief and (ii) the prefrontal cortex shows dissociable neural activity during pain relief following exerted vs. perceived pain control. This might reflect the higher grade of uncertainty during pain relief following perceived pain control mediated by the orbitofrontal and medial prefrontal cortex and processes of working memory and updating expectations during pain relief following exerted control mediated by the lateral prefrontal cortex.
Numerical simulation of shear-induced instabilities in internal solitary waves
Authors: Carr Magda , King Stuart E. , Dritschel David G. 
Published: August 2011

AbstractA numerical method that employs a combination of contour advection and pseudo-spectral techniques is used to simulate shear-induced instabilities in an internal solitary wave (ISW). A three-layer configuration for the background stratification, in which a linearly stratified intermediate layer is sandwiched between two homogeneous ones, is considered throughout. The flow is assumed to satisfy the inviscid, incompressible, Oberbeck–Boussinesq equations in two dimensions. Simulations are initialized by fully nonlinear, steady-state, ISWs. The results of the simulations show that the instability takes place in the pycnocline and manifests itself as Kelvin–Helmholtz billows. The billows form near the trough of the wave, subsequently grow and disturb the tail. Both the critical Richardson number (${\mathit{Ri}}_{c} $) and the critical amplitude required for instability are found to be functions of the ratio of the undisturbed layer thicknesses. It is shown, therefore, that the constant, critical bound for instability in ISWs given in Barad & Fringer (J. Fluid Mech., vol. 644, 2010, pp. 61–95), namely${\mathit{Ri}}_{c} = 0. 1\pm 0. 01$, is not a sufficient condition for instability. It is also shown that the critical value of${L}_{x} / \lambda $required for instability, where${L}_{x} $is the length of the region in a wave in which$\mathit{Ri}\lt 1/ 4$and$\lambda $is the half-width of the wave, is sensitive to the ratio of the layer thicknesses. Similarly, a linear stability analysis reveals that${\bar {\sigma } }_{i} {T}_{w} $(where${\bar {\sigma } }_{i} $is the growth rate of the instability averaged over${T}_{w} $, the period in which parcels of fluid are subjected to$\mathit{Ri}\lt 1/ 4$) is very sensitive to the transition between the undisturbed pycnocline and the homogeneous layers, and the amplitude of the wave. Therefore, the alternative tests for instability presented in Fructuset al. (J. Fluid Mech., vol. 620, 2009, pp. 1–29) and Barad & Fringer (J. Fluid Mech., vol. 644, 2010, pp. 61–95), respectively, namely${L}_{x} / \lambda \geq 0. 86$and${\bar {\sigma } }_{i} {T}_{w} \gt 5$, are shown to be valid only for a limited parameter range.
Lower temperature thresholds for oviposition and egg hatching of the Red Palm Weevil, Rhynchophorus ferrugineus (Coleoptera: Curculionidae), in a Mediterranean climate
Authors: Dembilio Ó. , Tapia G.V. , Téllez M.M. , Jacas J.A. 
Published: August 2011

AbstractThe red palm weevil, Rhynchophorus ferrugineus Olivier (Coleoptera: Curculionidae), is an economically important pest of palms worldwide. To better understand the phenology of R. ferrugineus populations in the Mediterranean basin, the objective of the present work has been to estimate the effect of temperatures within the range 10–25°C on the reproductive parameters of R. ferrugineus and to determine its lower temperature thresholds for oviposition and egg hatching. Our results confirm that oviposition in R. ferrugineus is strongly affected by temperature. Lower thresholds for oviposition and egg hatching (15.45° and 13.95°C, respectively) are below the mean monthly temperatures registered in winter in most of the northern shore of the Mediterranean basin. Under these circumstances, new palm infestations would be difficult during most of the winter. These results should be taken into account when planning some palm management practices, such as pruning or pesticide treatments, in areas under a Mediterranean climate.
Vascular rings and slings: interesting vascular anomalies
Authors: Phelan E , Ryan S , Rowley H 
Published: August 2011

AbstractIntroduction:A vascular ring refers to encirclement of the trachea and oesophagus by an abnormal combination of derivatives of the aortic arch system. These malformations can cause variable degrees of compression of the oesophagus, trachea or both. Symptoms can range from no effect to severe stridor, dyspnoea and/or dysphagia.Method and results:This study presents a case series of six patients treated over a six-year period (2003–2009), illustrating the features of four different types of vascular ring; these types are discussed in detail. The clinical presentation, radiology, and microlaryngoscopy and bronchoscopy findings are also discussed.Conclusion:The management of children with vascular rings requires a high index of clinical suspicion to ensure prompt diagnosis. As many of these children present with airway symptoms, the paediatric otolaryngologist plays a key role in identifying and assessing their anatomical anomalies.
Mastoiditis secondary to metastatic lung carcinoma: case report and literature review
Authors: Clamp P J , Jardine A H 
Published: August 2011

AbstractObjective:We present a case report and systematic review of acute mastoiditis caused by metastatic lung cancer.Case report:A 62-year-old woman developed acute mastoiditis as a complication of otitis media. Cortical mastoidectomy revealed deposits of metastatic non-small cell lung carcinoma around the sigmoid sinus. The patient had previously received treatment for lung cancer, but was thought to be in remission.Discussion:A literature review confirmed that this is the first reported case of mastoiditis caused by metastatic lung cancer. Only four similar case reports were identified: two caused by breast carcinoma, one by renal cell carcinoma and one by cholangiocarcinoma. Post-mortem histopathological studies suggest that temporal bone metastasis occurs in 22 per cent of oncology cases.Conclusion:This is the first reported case of mastoiditis caused by metastatic lung cancer. Metastasis to the temporal bone is not uncommon, but rarely causes mastoiditis.