bluuebunny/crossref_metadata_2025_split huggingface dataset:
Letrozole for Induction of Ovulation in PCOS Patients: Resistant to Clomiphene Citrate
Authors: Chowdhury TA , Mahmud Nusrat , Siddiqui Maruf 
Published: October 2010

ABSTRACT

Objective
To assess the efficacy of aromatase inhibitor letrozole for induction of ovulation in anovulatory polycystic ovary syndrome (PCOS) patients in whom clomiphene citrate (CC) treatment was unsuccessful.

Design
Prospective, nonrandomized, interventional, crossover trial, using anovulatory PCOS infertile patients previously treated with clomiphene citrate as their own historic controls.

Setting
Center for Assisted Reproduction (CARE), Department of Obstetrics and Gynecology, Bangladesh Institute of Research and Rehabilitation in Diabetes, Endocrine and Metabolic Disorders (BIRDEM), Dhaka, Bangladesh.

Patients
60 anovulatory PCOS infertile patients who received 150 mg of clomiphene citrate for at least 4 cycles on days 2 to 6 of the cycle with an unsatisfactory outcome (No mature follicle and/or endometrial thickness of equal or less than 0.7 cm) were the target population.

Intervention
5.0 to 7.5 mg of letrozole was given orally on days 2 to 6 of the cycle. Main outcome measures: Number and size of mature follicles, endometrial thickness and occurrence of ovulation.

Results
There was a statistically significant increase in the follicular size and endometrial thickness after the administration of letrozole. Ovulation occurred in 38 patients (63.33%) in the letrozole treated cycles. Most of developed follicles (68.42%-26 patients) were multiple and majority patients (63.16%) responded to the higher 7.5 mg dose.

Conclusion
Oral administration of letrozole is an effective agent for ovulation induction in clomiphene citrate resistant PCOS patients.
Randomized Double Blind Placebo-controlled Study to Evaluate the Role of M2-Tone as an Adjuvant Treatment in IUI Protocol by Assessing its Effects on Endometrial Morphology, Vasculature and Pregnancy Rate Using 3D Color Doppler in Female Infertility
Authors: Puri Randhir , Rao JP , Arora Shobhna 
Published: October 2010

ABSTRACT

Objective
To compare the efficacy of M2-Tone, a phytopharmaceutical, and placebo as an adjuvant in IUI protocol in improving endometrial receptivity as assessed by endometrial morphology, vascularity and pregnancy outcome in female infertility using the 3D color Doppler technique.

Design
Double blind placebo controlled comparative trial.

Setting
Outpatient clinic of MTTBC (Malhotra Test Tube Baby Center), Agra in India.

Patient(s)
Fifty-five patients with infertility were recruited. Twenty-eight patients were administered tablet M2-Tone and twenty-seven patients were given placebo. Both drugs were given orally in the dose of 2 tablets twice a day for three months prior to the IUI procedure.

Intervention(s)
M2-Tone, placebo, clomiphene citrate, hCG, 3D Color Doppler, IUI.

Main outcome measure(s)
Endometrial thickness, endometrial lining, endometrial vascularity, sex steroids and pregnancy rates.

Result(s)
Out of total 55 patients only 50 patients completed the study. In M2-Tone group endometrial thickness increased to mean 8.65 mm from 4.6 mm at baseline (Day 2 of menstrual cycle) whereas in placebo group it rose to mean 6.89 mm from 4.8 mm at baseline. The decrease in the mean score of uterine artery blood flow impedance (Pulsatility index PI) was 1.13 in M2-Tone group and 0.72 in placebo group. The uterine score in the M2-Tone group increased significantly from 3.15 to 13.31 and from 3.16 to 10.08 in placebo group. There was corresponding increase in pregnancy rate in the M2-Tone group (30.77%) as compared to the placebo group (16.66%). Though there was slight increase in the serum estradiol and progesterone levels in M2-Tone group compared to the placebo group the difference was not statistically significant.

Conclusion(s)
M2-Tone has shown better endometrial thickness, endometrial layering and better color flow to zone 3 of the endometrium compared to placebo. M2-Tone as an adjuvant treatment in IUI protocol showed significant improvement in pregnancy rate. This beneficial effect of M2-Tone can be attributed to improvement in the endometrial vascularity and morphology in the subjects by its modulating action on the hormonal status.
Role of Laparoscopic Ovarian Drilling as a First Line Management in Infertility with Polycystic Ovarian Disease
Authors: Shrivastava Deepti , Sindhu Bhute , Mukherjee Satarupa 
Published: October 2010

ABSTRACTPolycystic ovarian disease (PCOD) is the most common endocrine disorder in women of reproductive age. The pathogenesis is not completely clear still today. Problems in inducing ovulation in PCOD is well recognized. A retrospective study of last 3 years in patients attending the OPD in the Department of Obstetrics and Gynecology, JNMC, Sawangi, Wardha, who were diagnosed as cases of PCOD with complaints of infertility and irregular menstruatal cycle underwent laparoscopic ovarian drilling. It was concluded that the procedure had higher ovulation and successfull pregnancy rate. It is cost-effective, minimally invasive procedure with lesser hospital stay with less postoperative complications, being ideal for rural setup.
Cotton (Umbilical) Tape as Suture Material for Cervical Cerclage: A Case Series
Authors: Puri Randhir , Bellad MB , Shravage JC 
Published: October 2010

ABSTRACT

Introduction
The present case series was an attempt to find out cotton (umbilical) tape usefulness as suture material for cervical encerclage as it is presterilized, easily visible and economical.

Methods

Objective
To determine utility of cotton tape as suture material for cervical cerclage. Study design: A case series.

Place
KLES Hospital and District Hospital, Belgaum.

Period
1997 to 2001.

Inclusion criteria
Singleton pregnancy, gestational age by USG (14-26 weeks), H/o 2nd trimester abortions, H/o Pre-term labor, elective cerclage.

Exclusion criteria
Medical diseases, multiple pregnancy, emergency encerclage, fetal anomalies by USG, not willing to provide consent.

Outcome
Gestational age at delivery, fetal survival, morbidity [white discharge per vagina (PV), cervical dystocia, puerperal pyrexia].

Intervention
Cerclage with cotton tape.

Technique
Modified Mc Donald's: The suture is commenced from the posterior surface of the cervix and knot is put in the posterior surface.

Results
89.3% (25 women) had term deliveries, i.e. 37 to 40 weeks, 7.1% (2 women) had spontaneous delivery at 36 weeks and one women (3.6%) had pre-term delivery at 30 weeks with the fetal survival was 96.4%.

Conclusion
The present case series proves that the simple economical cotton (umbilical) tape is effective as a suture material for cervical encerclage. However a larger randomized trial can confirm these findings.
Role of Cervical Length as Predictor of Preterm Labor and a Comparison of Transabdominal versus Transvaginal Ultrasound in Determining the Accuracy of Cervical Length
Authors: Nanavati MS , Desai SV , Lakhani PD , Bansode AS 
Published: October 2010

ABSTRACT

Objectives
1. To evaluate the mean cervical length at 22 to 28 weeks of gestation by TAS and TVS and correlate its association with preterm labor.
2. To compare the difference in cervical length measured by the above two methods.

Methods
This was a prospective trial involving 100 pregnant women spanning a period of ten months.

Results
Eighteen women out of the 100 studied had preterm labor; of which 17 had a cervical length of less than 3 mm at 22 to 28 weeks. The percentage of women with preterm delivery with a short cervix was 83% by transabdominal scan (TAS) and 94% with transvaginal scan (TVS).

Conclusion
The mean cervical length was lesser amongst women who had a preterm delivery as compared to those with a term delivery. The mean cervical length by TAS was more than that by TVS thereby suggesting that TVS has a higher sensitivity for detection of preterm labor than TAS.
Comparative Evaluation of Saline Infusion Sonohysterography and Hysterolaparoscopy for Diagnosis of Uterine Cavity Abnormalities and Tubal Patency in Infertility: A One Year Cross- sectional Study
Authors: Dhumale Hema , Desai BR , Pujar Yeshita , Sherigar Bhavana , Patted Shobana 
Published: October 2010

ABSTRACT

Objective
To compare the diagnostic efficacy of saline infusion sonohysterography (SIS) with hysterolaparoscopy in evaluation of uterine cavity and tubal patency.

Methods
This prospective one year cross-sectional study was conducted at the assisted reproduction center (ARC), KLES Dr Prabhakar Kore Hospital and Medical Research Centre, Belgaum. A total of 60 patients underwent SIS for evaluation of uterine cavity and tubal patency. Subsequently all patients underwent hysterolaparoscopy with chromopertubation (CPT). Results of SIS and hysterolaparoscopy with chromopertubation were compared.

Results
For evaluation of uterine cavity, when compared with hysteroscopy, SIS had a sensitivity of 97.8%, specificity of 88.8%, positive predictive value (PPV) of 97.8% and negative predictive value (NPV) of 88.8%. For evaluation of tubal patency when SIS was compared to laparoscopy with CPT, SIS had a sensitivity of 83.3%, specificity of 82.9%, PPV of 42.9% and NPV of 97.5%.

Conclusion
Saline infusion sonohysterography is a noninvasive, simple, easy and cost-effective procedure. SIS is more sensitive and specific for evaluation of uterine cavity as compared to evaluation of tubal patency.
An Unusual Case of Postpartum Anasarca
Authors: Puri Randhir , Singh Jai Inder , Kiran KG 
Published: October 2010

ABSTRACT
A 21-year-old lady, primipara presented with breathlessness on exertion and generalized swelling of three weeks duration. Clinical examination revealed anasarca and features of cardiac failure. After evaluation, a diagnosis of peripartum cardiomyopathy was established based on echocardiographic findings of dilated cardiac chambers and poor left ventricular function. She responded well to treatment. The case is being reported for the diagnostic dilemma and rarity.
A Rare Case of Chorea Gravidarum
Authors: Gawande Madhuri , Ghike Sunita , Jain Sheela 
Published: October 2010

ABSTRACT
Chorea Gravidarum is the term given to chorea occurring during pregnancy. It is not an etiologically or pathologically distinct morbid entity but generic term for chorea of any etiology. We report a case of Chorea Gravidarum, who had past history of Rheumatic fever and Sydenham's Chorea in childhood. Factors associated with recurrence of chorea; those aggravating chorea during pregnancy and its management have been discussed.
Assess the Knowledge Regarding Pre-eclampsia and Its Self-care Measures among Antenatal Women Attending Antenatal Outpatient Department of KLES Dr Prabhakar Kore Hospital, Belgaum
Authors: José Namitha , Kharde Sangeeta 
Published: October 2010

ABSTRACT

The objectives of study were to
assess the knowledge regarding pre-eclampsia and self-care measures among pregnant woman. Find out an association between knowledge regarding pre-eclampsia and self-care measures and selected variables, develop an informational booklet on pre-eclampsia and self-care measures.

Methods
The design selected for the study is descriptive design. The study was conducted on 108 antenatal mothers below 20 weeks of gestational age and who are attending antenatal outpatient department of Dr KLES Prabhakar Kore's Hospital, Belgaum. Non- probability purposive sampling technique was used. The tool included background proforma, knowledge and self-care measures questionnaire on preeclampsia. The data was analyzed in terms of both descriptive and inferential analysis.

Results
Data analysis of level of knowledge revealed majority of mothers 80(74.07%) had average knowledge, 14(12.96%) had good and poor knowledge; and with regards to self-care measures (60.18%) had average knowledge, 41(37.96%) had good knowledge and 2(1.85%) had poor knowledge, association between the knowledge of mothers and selected variables revealed that the variables age, educational status, occupational status, income, religion, parity and area of residence shows an association with knowledge scores at 0.05 level of significance. Association between the self-care measures scores of mothers and selected variables revealed that the variables age, educational status, occupational status, income, religion and parity shows an association with knowledge scores at 0.05 level of significance. The variable type of family and area of residence in relation with knowledge scores of mothers are independent of each other.

Conclusion
The world has come a long way from the times when a woman surviving childbirth was considered to be blessed with a 'second life’ to the present. Application of appropriate prenatal care and management has largely eliminated maternal mortality frequently at the cost of preterm delivery. Based on the findings of the study, it is concluded that most of the subjects had average knowledge regarding preeclampsia and its self-care measures.
Uterine Artery Doppler in the Prediction of Preeclampsia and Adverse Pregnancy Outcome
Authors: Antsaklis Aris 
Published: October 2010

AbstractPreeclampsia and fetal growth restriction are major causes of perinatal mortality and morbidity. Several studies have shown that a generalized endothelial dysfunction is associated with these complications. Clinical trials have shown that pregnant women who demonstrate high resistance in uteroplacental blood flow are at higher risk for preeclampsia. Uterine artery Doppler studies both in the second and the first trimester can predict pregnancies at increased risk of the complications of impaired placentation. The sensitivity for predicting severe preeclampsia ranges between 80 and 90% for a false positive rate of 5 to 7%. Uterine artery Doppler screening at 20 to 24 weeks’ gestation is superior to first trimester screening, and appears to fulfill the requirements for a worthwhile screening test. Further research is needed to better assess the value of various combinations of uterine artery Doppler and maternal serum markers, for the prediction of adverse pregnancy outcome.
Ultrasound Assessment of Endometrial Receptivity in in vitro Fertilization Treatment
Authors: NG Ernest Hung Yu , HO Pak Chung 
Published: October 2010

Abstract
Ultrasonography of the endometrium is a noninvasive way to evaluate the chance of successful implantation during in vitro fertilization treatment. Ultrasound parameters of endometrial receptivity include endometrial thickness, endometrial pattern, endometrial volume, Doppler studies of uterine vessels and the endometrium. Endometrial thickness, pattern and volume are not predictive of pregnancy. A good blood supply towards the endometrium is usually considered to be an essential requirement for implantation. Doppler study of uterine arteries does not reflect the actual blood flow to the endometrium. Endometrial and subendometrial vascularity can be more objectively measured with three-dimensional power Doppler ultrasound. However, the role of endometrial and subendometrial vascularity in predicting pregnancy of in vitro fertilization treatment remains controversial.
Cerebral Palsy: State of Art
Authors: Honemeyer Ulrich , Talic Amira 
Published: October 2010

AbstractCerebral palsy (CP) is the most common motor disability in childhood. It affects 2 to 2.5 children in 1000 live-births, with 20 to 30 fold increased prevalence in preterm infants. Despite of progress in perinatal care, the prevalence of cerebral palsy did not change in the last 50 years. New knowledge about etiological factors, such as inflammation, elevated level of cytokines, vascular strokes and genetic factors shift the origin of cerebral palsy mostly into antenatal period, making intrapartal damage responsible for less than 10% of cases. CP is becoming increasingly the subject of interdisciplinary research. Fetal neurosonography with a growing number of studies promises better understanding of the normal functional maturation of the human brain which may lead to effective prevention and treatment of cerebral palsy. Advances in 4D ultrasound resulted in development of KANET as tool for detection of abnormal fetal behavior.
Four-dimensional Ultrasound Evaluation of Fetal Neurobehavioral Development
Authors: Tanaka Hirokazu , Sasaki Mutsuko 
Published: October 2010

AbstractThe introduction of four-dimensional (4D) ultrasound techniques would facilitate fetal behavioral assessment in three-dimensions in realtime during pregnancy. We describe the latest 4D sonographic studies on fetal behavior, especially fetal whole-body movements and facial expressions in all three trimesters of pregnancy and the continuation of behavior from the fetal to neonatal period. Moreover, we introduce a new scoring system (KANET, Kurjak Antenatal Neurological Test) for assessment of the fetal neurological status using 4D ultrasound. 4D ultrasound also facilitated the evaluation of inter-human contact in twin pregnancies in utero. This novel technique may assist in the evaluation of fetal behavior and inter-twin contact, and offer potential advantages relative to conventional two-dimensional ultrasound. 4D ultrasound should become an important modality in future research on fetal neurobehavioral development and the prenatal identification of severely brain-damaged infants. Further studies involving a larger sample size are needed to ascertain the role of 4D ultrasound in the evaluation of fetal neurobehavioral development.
Ultrasonic Characterization of Adnexal Masses
Authors: Honemeyer Ulrich , Plavsic Sanja Kupesic 
Published: October 2010

Abstract
Adnexal masses have an etiological spectrum ranging from gynecologic to non-gynecologic causes. Because they can be benign or malignant, their evaluation has to include a careful analysis of the patients history, a physical examination, and laboratory and imaging tests. Transvaginal ultrasonography remains the standard for evaluation of adnexal masses. Findings suggestive of malignancy in an adnexal mass include a solid component or intracystic proliferations, thick septations (greater than 2 to 3 mm), bilateral occurrence, blood flow within the solid component of the mass, and presence of ascites. Tumor-neoangiogenesis has typical features of flow pattern and vascular architecture, indicative of malignancy, which can be visualized by Doppler ultrasound. Power Doppler with its increased sensitivity for slow flow and small vessels is ideal for this purpose and, in combination with acquisition of a volume data set of the region of interest (RoI), gives new insights in tumor angiology and appears to be an additional diagnostic tool. An important predictor of malignancy is a resistance index (RI) below 0.42 in arterial tumor vessels. 3D rendering modes like magic cut, NICHE mode, power Doppler glass body rendering, can make valuable contributions to differential diagnose of adnexal masses. A variety of adnexal masses is illustrated in their specific sonographic appearance, with special regard to ovarian carcinoma.
Study of Plastic Deformation in Hexagonal Metals by Interrupted In‐Situ EBSD Measurement
Authors: Bao Lei , Lecomte Jean‐Sébastien , Schuman Christophe , Philippe Marie‐Jeanne , Zhao Xiang , Esling Claude 
Published: October 2010

AbstractThe present work was undertaken to provide information, lacking in the literature, on the lattice rotation, and the role of twinning during cold rolling of commercial purity titanium (T40). The proposed method consists of determining the individual rotation of the grains induced by low to intermediate deformation (up to 30% in thickness reduction) and following the rotation field using electron backscattered diffraction (EBSD) measurements in a high resolution FEG SEM at different steps of deformation (10 and 20%). We have especially studied the formation, the evolution, and the role of mechanical twins. According to the former research, during deformation at room temperature, three different types of twin systems were activated: ${\left\{ {10\overline {1} 2} \right\}}$ tensile twinning, ${\left\{ {11\overline {2} 2} \right\}}$ compression twinning, and – to a small extent – ${\left\{ {11\overline {2} 1} \right\}}$ tensile twinning depending on the grain orientation. Secondary twins (often ${\left\{ {10\overline {1} 2} \right\}}$ within ${\left\{ {11\overline {2} 2} \right\}}$ twins) were activated in the grains oriented favorably for this secondary twinning. This resulted in a heterogeneous microstructure in which grains were refined in some areas. It also induced reorientation of the c‐axes to stable orientations. No twins of higher order than the second order twins could be found. The rotation flow field was measured by following the rotation of 800 grains. It was possible to determine the individual grains rotations as well as the average flow field. For grains having twinned parts, the lattice rotation of the matrix is similar to that of the grains having a similar crystallographic orientation but without any twins. Twins form in grains having specific orientations with respect to the macroscopic stress field; they can grow in the grain with increasing strain and may consume almost the whole matrix.
A methyltitanocene complex of schisandrol A with high efficacy against multi‐drug resistant cervix and breast carcinoma cells
Authors: Gmeiner Alexander , Effenberger‐Neidnicht Katharina , Zoldáková Miroslava , Schobert Rainer 
Published: October 2010

AbstractThe objective of this work was to combine the ABC‐transporter inhibition characteristic of esters of the Schisandra sphenantera metabolite schisandrol A with the growth inhibitory and anti‐migratory effects typical of titanium complexes. To this end dimethyltitanocene, (h5‐C5H5)2Ti(CH3)2, was reacted with the vicinal diol schisandrol A to afford the schisandroxy(methyl)titanocene (1) as a stable water‐soluble solid. In MTT assays against seven tumor cell lines it proved distinctly more cytotoxic than schisandrol A or dimethyltitanocene or combinations of these. It reached single‐digit micromolar IC50(72 h) values against cells of leukemia HL‐60, melanoma 518A2 and also resistant cervix carcinoma KB‐V1/vbl and resistant breast carcinoma MCF‐7/topo. Non‐malignant fibroblasts were virtually insensitive to it [IC50 (72 h) > 50 µM]. In addition, the new complex inhibited the p‐gp drug transporters of KB‐V1/vbl cells and prevented a regrowth and closure of scratch wounds in cancer cell cultures (‘wound‐healing’ assay) when applied in concentrations < 1 µM, which is an indication of a potential anti‐migratory and anti‐invasive activity in solid tumors. Copyright © 2010 John Wiley & Sons, Ltd.
Agency satisfaction with electronic record management systems: A large‐scale survey
Authors: Hu Paul Jen‐Hwa , Hsu Fang‐Ming , Hu Han‐fen , Chen Hsunchun 
Published: October 2010

AbstractWe investigated agency satisfaction with an electronic record management system (ERMS) that supports the electronic creation, archival, processing, transmittal, and sharing of records (documents) among autonomous government agencies. A factor model, explaining agency satisfaction with ERMS functionalities, offers hypotheses, which we tested empirically with a large‐scale survey that involved more than 1,600 government agencies in Taiwan. The data showed a good fit to our model and supported all the hypotheses. Overall, agency satisfaction with ERMS functionalities appears jointly determined by regulatory compliance, job relevance, and satisfaction with support services. Among the determinants we studied, agency satisfaction with support services seems the strongest predictor of agency satisfaction with ERMS functionalities. Regulatory compliance also has important influences on agency satisfaction with ERMS, through its influence on job relevance and satisfaction with support services. Further analyses showed that satisfaction with support services partially mediated the impact of regulatory compliance on satisfaction with ERMS functionalities, and job relevance partially mediated the influence of regulatory compliance on satisfaction with ERMS functionalities. Our findings have important implications for research and practice, which we also discuss.