bluuebunny/crossref_metadata_2025_split huggingface dataset:
Survival in Patients With Evidence of Pulmonary Thromboembolism on Ventilation‐Perfusion SPECT 12 Weeks After Double Lung Transplantation: A Retrospective Cohort Study
Authors: Mohammad Milan , Kristensen Anna W. , Hartmann Jacob P. , Wareham Neval E. , Buttar Sana N. , Greve Anders M. , Lund Thomas K. , Jensen Kristine , Schultz Hans H. L. , Perch Michael , Berg Ronan M. G. , Mortensen Jann 
Published: February 2025

ABSTRACTBackgroundPatients who have undergone double lung transplantation (DLTx) are at increased risk of pulmonary thromboembolism (PTE). Although the presence of clinically overt PTE can adversely affect short‐term mortality, the prognostic impact of asymptomatic (silent) PTE detected by routine imaging after DLTx is unclear. This study aimed to determine whether PTE identified by routine ventilation‐perfusion single‐photon emission computed tomography (V̇‐Q̇ SPECT) 12 weeks post‐DLTx is associated with subsequent all‐cause and graft‐related mortality.MethodsSingle‐center retrospective cohort study evaluating 130 DLTx recipients who underwent routine V̇‐Q̇ SPECT imaging 12 weeks posttransplant between 2012 and 2017. V̇‐Q̇ SPECT scans were assessed for perfusion and ventilation defects indicative of PTE. The association between PTE and mortality outcomes was analyzed using multivariable Cox regression, Kaplan‐Meier survival curves, and cumulative incidence functions.ResultsPTE was identified in 24.6% (n = 32) of the patients 12 weeks post‐DLTx. After 3 months of follow‐up, there was no detectable difference in lung function between patients with and without PTE. Moreover, the presence of PTE was not associated with increased hazard ratios for all‐cause mortality (HR = 0.72; 95% CI: 0.37–1.41; p = 0.34) or graft‐specific mortality (HR = 0.95; 95% CI: 0.42–2.16; p = 0.91).ConclusionsPTE is a frequent finding on routine V̇‐Q̇ SPECT 12 weeks post‐DLTx that does not inform risk of all‐cause or graft‐related mortality. These findings suggest that an incidentally detected PTE in asymptomatic patients may not necessitate changes in clinical management for asymptomatic DLTx patients.
Pharmacokinetics and ADME Characterization After Oral and Intravenous Administration of [14C]‐Ziftomenib in Healthy Male Participants
Authors: Mitra Amitava , Ahsan Julie Mackey , Tabachri Marilyn , El‐Shahat Taha , Leoni Mollie , Dale Stephen 
Published: February 2025

ABSTRACTZiftomenib, a potent, selective inhibitor that binds menin at the lysine methyltransferase 2 interaction site, has demonstrated promising clinical activity with manageable toxicity in heavily pretreated patients with acute myeloid leukemia (AML) and nucleophosmin 1 mutations. This phase 1, open‐label study characterized the absorption, metabolism, excretion, and bioavailability of ziftomenib in healthy men and comprised two parts. In part A, a single oral dose of ziftomenib 400 mg (containing 250 μCi [14C]‐ziftomenib) was given to evaluate routes and rates of elimination, total radioactivity, and other pharmacokinetic parameters. In part B, a single oral dose of ziftomenib 400 mg followed by an intravenous dose of ziftomenib < 100 μg (containing 1 μCi [14C]‐ziftomenib) was administered to evaluate absolute bioavailability (both n = 8 patients). A median tmax of 3.5 h and an elimination t1/2 of 61.5 h demonstrated rapid ziftomenib absorption and enabled once‐daily dosing. Total radioactivity recovery was 89.7% in feces and 0.5% in urine over 480 h. Absolute bioavailability of 12.9% was observed. Ziftomenib was primarily metabolized by oxidation, N‐demethylation, and N‐dealkylation, with 19 metabolites recovered in plasma. All metabolites were considered minor (< 10% of total drug‐related exposure). Ziftomenib was the most abundant plasma component (> 10% of total drug‐related exposure). In conclusion, ziftomenib underwent limited metabolism following absorption and was primarily excreted as unchanged parent drug in feces. Ziftomenib was well tolerated with no new safety concerns in healthy men. Considering the pharmacokinetic profile and manageable safety outcomes, these findings support further clinical investigation of ziftomenib as treatment for AML.
A Rare Case of Bullous Melanoma With Subepidermal Separation
Authors: Taş‐Aygar Gamze , Gönül Müzeyyen , Çevirgen‐Cemil Bengü , Gökçe Aysun , Kartal Selda Pelin 
Published: February 2025

ABSTRACTSeveral rare subtypes of melanoma, beyond the classic variants, have been described in the literature. The rarity of these variants can hinder recognition and lead to delays in clinical diagnosis. Bullous melanoma is one such rare subtype. Blister formation in bullous melanoma can occur either intraepidermally or subepidermally. While most reported cases exhibit intraepidermal separation, only three cases with subepidermal separation have been documented to date. Here, we present a rare case of bullous melanoma with subepidermal separation characterized by exceptional recurrent bullous episodes.
Ancillary Tools for the Diagnosis of CIC‐Rearranged Sarcoma: A Comprehensive Review
Authors: Cloutier Jeffrey M. , Al‐Rohil Rami N. , Patel Rajiv M. , Ko Jennifer S. , Linos Konstantinos 
Published: February 2025

ABSTRACTCIC‐rearranged sarcoma is a rare and aggressive undifferentiated round cell sarcoma that presents significant diagnostic challenges due to its histologic overlap with other round cell sarcomas. This review, conducted on behalf of the American Society of Dermatopathology Appropriate Use Criteria Committee (soft tissue subgroup), provides an overview of current immunohistochemical, cytogenetic, and molecular tests used to support the diagnosis of CIC‐rearranged sarcoma. This comprehensive analysis included 36 studies, encompassing 436 CIC‐rearranged sarcomas. The immunohistochemical markers, CD99 (typically non‐diffuse), nuclear WT1, ETV4, and DUX4, were found to be relatively highly sensitive for CIC‐rearranged sarcoma (CD99: 87%, WT1: 83%, ETV4: 85%, DUX4: 97%). However, the specificity of these markers is variable, with CD99 being highly non‐specific, while WT1 (81%–90%), ETV4 (95%), and DUX4 (100%) offering greater specificity. CIC break‐apart FISH can be a helpful and cost‐effective assay for detection of CIC‐rearrangements, but has a false‐negative rate that ranges from 26% to 43%. Next‐generation sequence RNA fusion analysis also carries a risk of false negatives, which may be partly mitigated through manual data review. Ultimately, an accurate diagnosis of CIC‐rearranged sarcoma requires careful morphologic assessment in combination with immunohistochemical studies and cytogenetics/molecular assays.
Integrating routine screening for pregnancy intention and contraceptive use into care of women who use alcohol or other drugs
Authors: Murnion Bridin , Chase Vicki , Carniato Grace , Masters Kate , McNamara Kelly 
Published: February 2025

AbstractIntroductionThere are high rates of unplanned pregnancy and low rates of contraceptive use in women with substance use disorders. Women who use drugs experience many barriers to health. In addiction treatment services in New South Wales, Australia, patients undergo routine health screening on treatment entry and annually thereafter. An integrated pregnancy and contraceptive screening tool was developed. The aim of this cross‐sectional study was to report the feasibility and preliminary outcomes of this tool.MethodsA pregnancy intention screening (PIS) tool was developed and integrated into the electronic medical record and the annual routine screening. This tool consisted of four yes/no questions about current pregnancy, future pregnancy plans and contraceptive use. Responses to these questions are reported. Descriptive statistics were used to report demographic and outcome data.ResultsOne hundred women were offered and completed the survey. There were low rates of effective or highly effective contraceptive use (24.5 percent of eligible participants). Seventy‐four percent of participants wanted further information on contraception.Discussion and ConclusionsAs with other studies, our studies demonstrate low rates of contraceptive use and high rates of interest in contraception use among women who use drugs. The PIS tool was completed by all women to whom it was offered, suggesting high levels of patient acceptability. Integration of a PIS tool was effective in identifying women with contraceptive needs and was acceptable to women.
The Distribution of Wild Bee Species Along a Latitudinal Gradient in Northern Europe Depends on Their Flower Preferences
Authors: Torvanger Marianne S. , Dupont Yoko L. , Olesen Jens M. , Rasmussen Claus , Madsen Henning B. , Star Bastiaan , Sydenham Markus A. K. 
Published: February 2025

ABSTRACTAimThe functional diversity of bees contribute to the maintenance of plant biodiversity because different species of wild bees prefer and pollinate different plants. Many bees, in particular species with narrow flower preferences or specialised habitat requirements, are threatened by landscape homogenisation and climate change. Nonetheless, we still lack an understanding of large‐scale impacts of anthropogenic stressors on the distribution of wild bee species with different flower preferences.LocationNorthern Europe: Norway, Denmark and Germany.MethodsWe combine a dataset comprising ~30,000 observations of presences or absences of bee occurrences from structured surveys at 269 sites in northern Europe to investigate if flower preferences modulate species distributions across multiple environmental gradients. Bees were assigned a continuous functional trait separating preference for short vs. tubular flowers.ResultsWe observe that bee flower preference for either tubular flowers (Fabaceae) or plants with shallow flowers (including Apiaceae and Brassicaceae) can be described by a continuous flower preference trait score. The likelihood of observing a bee along a latitudinal gradient—encompassing variation in temperature, atmospheric N deposition and elevation—is dependent on its flower preference trait score. Specifically, bees with preferences for tubular flowers have a higher likelihood of occurrence with higher latitudes, while bees with preference for non‐tubular flowers increase towards the south.Main ConclusionsOur results improve our understanding of how species‐specific variation in flower preferences drives community‐wide shifts in diversity and can therefore help devise region‐specific conservation strategies.
Distance From the Road, Habitat Type and Environmental Factors Predict Distribution of Invasive and Native Plant Species in the Above‐Ground Vegetation and Soil Seedbanks
Authors: Dai Wanting , Oduor Ayub M. O. , Guo Chaodan , Quan Zhanjun , Li Junsheng , Zhao Caiyun 
Published: February 2025

ABSTRACTAimRoad networks are common landscape disturbances that can facilitate the spread of invasive plants. This study explored the influence of distance from the road, habitat type and broader environmental factors in shaping the distribution patterns of both invasive and native species in the above‐ground vegetation and soil seed banks.LocationGuangxi, China.MethodsWe collected data on plant species composition from both soil seed banks and above‐ground vegetation at six distances from the road edge: 0 m, 2 m, 4 m, 9 m, 14 m and 24 m in three habitat types, including abandoned land, Eucalyptus plantations and natural secondary forests. We collected data on environmental variables at each sampling location. We examined the compositional similarity of plant communities by non‐metric multidimensional scaling (NMDS) and identified the influence factors by redundancy analysis (RDA).ResultsOur results indicated that invasive species richness decreased with distance from the road, especially in natural secondary forests. Conversely, native species did not show consistent distribution patterns relative to distance from roads across the various habitats. The composition of invasive plant communities was similar in both soil seed banks and above‐ground vegetation, while only 13.33% of native species identified in the soil were observed in the above‐ground vegetation. Road characteristics, human disturbance and soil properties correlated with the distribution of invasive and native species, with the strength of these correlations varying among habitat types. The richness and density of native plants were associated with the presence of invasive alien plants at various distances from the road across the three types of habitats.Main ConclusionsThe study highlights that proximity to the road, habitat type and environmental factors are critical in determining the distribution of plant species within nature reserves. Moreover, it underscores the importance of integrating both above‐ground and seed bank perspectives for effective management strategies to control invasive species and promote native plant communities.
Care in Times of Crisis: Phenomenological, Political and Theological Perspectives
Authors: Jørgensen Anders Skou 
Published: February 2025

ABSTRACTThe threat of increasingly adverse existential conditions has prompted activist groups like Extinction Rebellion to enact civil disobedience. In this article, this sort of behavior is interpreted as a message about not only what they care about, but about what they think their surroundings ought to care about. Care is investigated through the lens of hermeneutic phenomenology as a call to awareness of the value of something or someone. By drawing especially on Jean‐Luc Marion's phenomenology of love and on Joan Tronto's early work on political care, it is shown how to bridge phenomenological concerns with an ethics of caring for someone or something. It is argued that that we may, in some circumstances, demand that other people care about what we care about. Last, these reflections are connected to Sallie McFague's theological suggestion of a friendship model of the divine‐creation relationship.
Screening for disordered eating in adolescents with Type 1 diabetes: A comparison of Diabetes Eating Problem Survey Revised (DEPS‐R) and Youth Eating Disorder Examination Questionnaire (YEDE‐Q) with item‐level analysis
Authors: Abild Caroline B. , Clausen Loa , Wisting Line , Bruun Jens Meldgaard , Kristensen Kurt , Støving Rene Klinkby , Vestergaard Esben Thyssen 
Published: February 2025

AbstractAimsPeople with type 1 diabetes (T1D) face an increased risk of disordered eating (DE) and eating disorders (ED), associated with glucose levels outside target range and an increased risk of complications. The aim of this study was to investigate the type and severity of DE and assess the item accuracy of the Diabetes Eating Problem Survey Revised (DEPS‐R) compared to the Youth Eating Disorder Examination Questionnaire (YEDE‐Q) in the screening of DE among adolescents with T1D.MethodsCross‐sectional online survey including DEPS‐R, YEDE‐Q and medical records. Item to total analysis with correlations, and group comparisons were performed.ResultsA total of 131 adolescents between 11 and 19 (mean age 15.3 ± 2.2) years completed both DEPS‐R and YEDE‐Q, identifying 21.4% and 22.9% with DE, respectively. Significantly more females (>30%) than males (≈5%) were identified in both measures. More than 50% reported insulin restriction in DEPS‐R vs. 1.5% in YEDE‐Q. YEDE‐Q yielded 32% with weight controlling behaviours, however, half of these were unidentified by DEPS‐R. Item‐total analysis of DEPS‐R showed that item 10 had small correlations to both total score and clinical variables.ConclusionThis study confirms the clinical relevance of DEPS‐R, including associations between DE and female sex, older age, and glucose levels outside target range, however, it may not accurately capture distinct ED risk behaviours, such as excessive exercise or shape and weight related insulin restriction. The item‐total analysis shows that the relevance of item 10 should be further investigated.
Use of sodium‐glucose cotransporter‐2 inhibitors and risk of dementia: A population‐based cohort study
Authors: Zhuo Lin , Zhang Baixue , Yin Yueqi , Sun Yexiang , Shen Peng , Jiang Zhiqin , Zhan Siyan , Zhao Houyu 
Published: February 2025

AbstractBackground and AimsThe effects of sodium‐glucose co‐transporter 2 inhibitors (SGLT‐2i) on dementia risk have not been assessed in the Chinese population. We aimed to assess the association between the use of SGLT‐2i and dementia incidence in a mainland Chinese population.Materials and MethodsA target trial of SGLT‐2i vs. dipeptidyl peptidase 4 inhibitors (DPP‐4i) was emulated, with cohorts of type 2 diabetes mellitus patients who were new users of SGLT‐2i or DPP‐4i being assembled using the Yinzhou Regional Health Care Database. Inverse probability of treatment weighting (IPTW) was applied to control potential confounding, and a Cox model was used to estimate the hazard ratio (HR) of the association between the use of SGLT‐2i and incident dementia.ResultsThe final cohort included 47 335 new users of DPP‐4i or SGLT‐2i. In the primary analysis, the incidence of dementia was 500.2 and 347.5 per 100 000 person‐years in users of DPP‐4i and SGLT‐2i, respectively. SGLT‐2i use was associated with a reduced risk of incident dementia after adjusting for potential confounding using IPTW, with an HR of 0.74 (95% CI, 0.60–0.93). The results were generally consistent in various subgroup analyses and sensitivity analyses.ConclusionsThe use of SGLT‐2i is associated with a decreased risk of dementia incidence in the study population in mainland China.
Valve It Right? Can Transthoracic Imaging Prevent CIED‐Induced Tricuspid Regurgitation?
Authors: Bourg Corentin , Donal Erwan 
Published: February 2025

ABSTRACTThe subcostal en face view of the tricuspid valve has emerged as a promising echocardiographic technique for visualizing right ventricular (RV) lead positions in patients with cardiac implantable electronic devices (CIEDs). This approach offers the potential to prevent tricuspid regurgitation (TR) by allowing rhythmologists to adjust lead positions in real time, ensuring optimal device placement and minimizing valve interference. A study by Zach et al. (2024) demonstrated the feasibility of this technique in 64% of patients, offering a viable alternative when 3D echocardiography is unavailable or non‐diagnostic. The study found no significant correlation between lead position and TR severity, suggesting that other factors may contribute to TR development. While the subcostal en face view holds significant promise, limitations such as poor image quality in patients with obesity, abdominal pathologies, or multiple leads, as well as the need for experience to maximize success rates, must be addressed. Future prospective studies are needed to validate the clinical benefits of the subcostal en face view during CIED implantation, including its impact on procedural duration and TR prevention. This technique represents an important step toward enhancing patient safety and improving CIED implantation protocols.
Body composition markers are more strongly associated with type 2 diabetes than inflammatory markers—Results from the study of health in Pomerania
Authors: Bibi Saima , Naeem Muhammad , Schipf Sabine , Bahls Martin , Dörr Marcus , Friedrich Nele , Nauck Matthias , Bülow Robin , Völzke Henry , Markus Marcello Ricardo Paulista , Ittermann Till 
Published: February 2025

AbstractBackground and AimsEvidence links body composition and inflammatory markers with type 2 diabetes (T2D). However, the comparative analysis of body composition markers derived from different modalities and inflammatory markers in relation to T2D remains unexplored. This study aims to evaluate and compare the association of body composition and inflammatory markers with T2D.MethodsWe included 4043 participants (2081 female, 51.4%) aged 20–84 enrolled in the population‐based Study of Health in Pomerania. Multivariable logistic regression models adjusted for confounding were used to analyse associations of standardized body composition markers derived from classic anthropometry, bioelectrical impedance analysis, magnetic resonance imaging as well as inflammatory markers C‐reactive protein, white blood cell count, fibrinogen, ferritin and CRP‐to‐albumin ratio with prevalent T2D.ResultsBody composition markers were more strongly associated with T2D than inflammatory markers. Waist circumference exhibited the strongest association with T2D (female: odds ratio (OR) = 2.55; 95% confidence interval [CI]: 2.17–3.00; male: OR = 2.20; 95% CI: 1.86–2.60). Similarly, body weight (female: 2.07; 1.78‐2.41; male: OR = 1.99; 95% CI = 1.71–2.31), waist‐to‐height ratio (female: OR = 2.39; 95% CI = 2.05–2.77; male: 2.28; 1.92–2.70) and visceral adipose tissue (female: 3.02; 95% CI = 2.11–4.32; male: 1.50; 1.19–1.89) showed strong associations with T2D. Among inflammatory markers, white blood cell count in male and CRP‐to‐albumin ratio in female exhibit the strongest association with T2D.ConclusionsBody composition markers seem to be more tightly associated with prevalent T2D compared to inflammatory markers.
GEE‐PICX: generating cloud‐free Sentinel‐2 and Landsat image composites and spectral indices for custom areas and time frames – a Google Earth Engine web application
Authors: Pflumm Luisa , Kang Hyeonmin , Wilting Andreas , Niedballa Jürgen 
Published: February 2025

Earth observation satellites are collecting vast amounts of free and openly accessible data with immense potential to support environmental, economic, and social fields. As the availability of remotely sensed data increases, so do the methods for accessing and processing it. Many solutions exist for creating cloud‐free image composites from often cloudy satellite data, but these typically require coding skills or in‐depth training in remote‐sensing techniques. This technical barrier prevents many researchers and practitioners from utilising available satellite data. The few user‐friendly solutions that exist often have limitations in terms of data export size and quality assessment capabilities. We developed GEE‐PICX, a web application with an intuitive graphical user interface on the cloud computing platform Google Earth Engine. This tool addresses the aforementioned challenges by creating cloud‐free, analysis‐ready image composites for user‐defined areas and time periods. It utilises Sentinel‐2 and Landsat 5, 7, 8, and 9 images and offers global coverage. Users can aggregate image composites annually or seasonally, with data availability starting from 1984 (the launch of Landsat 5). The workflow automatically filters all available satellite data according to user input, removing clouds, cloud shadows, and snow. It provides spectral band information, calculates various thematic spectral indices (including vegetation, burn, built‐up area, bare soil, snow, moisture, and water indices), and includes a quality assessment band indicating the number of valid scenes per pixel. GEE‐PICX offers a customizable tool for creating custom data products from freely accessible satellite data, catering to researchers with limited remote sensing experience. It provides extensive temporal and global spatial coverage, with server‐side processing eliminating hardware constraints. The tool facilitates easy export of time series as ready‐to‐use rasters with numerous spectral indices, supporting environmental programmes and biodiversity research across various disciplines.Keywords: cloud masking, cloud‐free image mosaic, environmental monitoring, remote sensing, satellite imagery, time series