bluuebunny/crossref_metadata_2025_split huggingface dataset:
Applying machine learning to international drug monitoring: classifying cannabis resin collected in Europe using cannabinoid concentrations
Authors: Freeman Tom P. , Beeching Edward , Craft Sam , Di Forti Marta , Frison Giampietro , Lindholst Christian , Oomen Pieter E. , Potter David , Rigter Sander , Rømer Thomsen Kristine , Zamengo Luca , Cunningham Andrew , Groshkova Teodora , Sedefov Roumen 
Published: May 2024

AbstractIn Europe, concentrations of ∆9-tetrahydrocannabinol (THC) in cannabis resin (also known as hash) have risen markedly in the past decade, potentially increasing risks of mental health disorders. Current approaches to international drug monitoring cannot distinguish between different types of cannabis resin which may have contrasting health effects due to THC and cannabidiol (CBD) content. Here, we compared concentrations of THC and CBD in different types of cannabis resin collected in Europe (either Moroccan-type, or Dutch-type). We then tested the ability of machine learning algorithms to classify the type of cannabis resin (either Moroccan-type, or Dutch-type) using routinely collected monitoring data on THC and CBD. Finally, we applied the optimal algorithm to new samples collected in countries where the type of cannabis resin was unknown, the UK and Denmark. Results showed that overall, Dutch-type samples had higher THC (Hedges’ g = 2.39) and lower CBD (Hedges’ g = 0.81) than Moroccan-type samples. A Support Vector Machine algorithm achieved classification accuracy exceeding 95%, with little variation in this estimate, good interpretability, and plausibility. It made contrasting predictions about the type of cannabis resin collected in the UK (94% Moroccan-type; 6% Dutch-type) and Denmark (36% Moroccan-type; 64% Dutch-type). In conclusion, we provide proof-of-concept evidence for the potential of machine learning to inform international drug monitoring. Our findings should not be interpreted as objective confirmatory evidence but suggest that Dutch-type cannabis resin has higher THC concentrations than Moroccan-type cannabis resin, which may contribute to variation in drug markets and health outcomes for people who use cannabis in Europe.
Detrimental effects of scene manipulations on temperature-based time since death estimation
Authors: Sauer Patrick , Lux Constantin , Gruber Hannes , Verhoff Marcel A. , Ramsthaler Frank , Kern Natascha , Kettner Mattias 
Published: May 2024

AbstractIn forensic casework, time since death (TSD) estimations may play a crucial role to establish chains of events as well as for alibi assessment in homicide cases. Classical TSD estimation relies on reasonably stable ambient temperatures and a correct documentation of ambient and rectal temperatures. This constancy is in some cases disturbed by post-discovery alterations of the crime scene, e.g. opening a window. In order to develop a better understanding of this alteration-based detrimental impact on TSD estimation as well as to identify feasible recommendations for casework, the present pilot study examined ambient temperature effects of different window opening scenarios regarding various time intervals (5 to 360 min) in a furnished 10 m2 apartment during winter. In this context, in addition to the ambient temperature and thus the cooling rate of the room, re-approximation to initial room temperature, potential influences on a nomogram-based time since death estimation using a fictitious case, and the impact of the measurement height above the ground were investigated. Our data indicate a significant reduction of the mean temperature decrease rate after 15 min regardless of the remaining opening time and a correlation with the size of the respective opening surfaces. Re-approximation to initial room temperatures was observed with up to three times longer than the initial opening time. There was no evidence of a substantial advantage of temperature measurements above the level of the corpse (> 0.1 m). The limitations of the study and its applicability for forensic casework are critically reviewed.
Neurological symptoms in adults with Gaucher disease: a systematic review
Authors: Imbalzano Gabriele , Ledda Claudia , Romagnolo Alberto , Covolo Anna , Lopiano Leonardo , Artusi Carlo Alberto 
Published: May 2024

Abstract
Introduction
Gaucher disease (GD) is classically divided into three types, based on the presence or absence of neurological signs and symptoms. However, presentation can be highly variable in adulthood, and this aspect has not been adequately addressed in the literature so far. We performed a systematic literature review to analyze the entire spectrum of neurological manifestations in adult patients previously classified as GD type I, II, or III, evaluating the role of variants in different neurological manifestations.

Methods
We searched databases for studies reporting clinical data of adult GD patients (age ≥ 18). Data extraction included GD types, GBA1 variants, age at disease onset and diagnosis, duration of GD, and age at onset and type of neurological symptoms reported.

Results
Among 4190 GD patients from 85 studies, 555 exhibited neurological symptoms in adulthood. The median age at evaluation was 46.8 years (IQR 26.5), age at neurological symptoms onset was 44 years (IQR 35.1), and age at GD clinical onset was 23 years (IQR 23.4). Parkinsonism, including Parkinson’s disease and Lewy Body dementia, was the most reported neurological manifestation. Other symptoms and signs encompassed oculomotor abnormalities, peripheral neuropathy, seizures, myoclonus, and cerebellar, cognitive and psychiatric symptoms. The genotype N370S/N370S mostly presented with Parkinsonism and the L444P variant with severe and earlier neurological symptoms.

Conclusion
The findings of this systematic review highlight: (1) the relevance of a comprehensive neurological assessment in GD patients, and (2) the importance of considering possible undiagnosed GD in adult patients with mild systemic symptoms presenting unexplained neurological symptoms.
The impact of Vitreo-Macular interface abnormalities on the response to Anti-VEGF therapy for centre involving diabetic macular oedema
Authors: Maguire Matthew , Laidlaw Dah , Davies Nigel , Hammond Christopher 
Published: May 2024

Abstract
Background
The influence of Vitreomacular Interface Abnormalities (VMIA) such as Epiretinal Membrane (ERM) and/or vitreomacular traction (VMT) on the response of patients with Centre Involving Diabetic Macular Edema (CIDME) to standard of care Anti-VEGF medications is under-researched.
The aims of this study were:

To determine the incidence of VMIA at baseline and 12 months amongst treatment naive patients commencing anti-VEGF treatment

To compare the response to Anti-VEGF medications at 3 monthly intervals for 12 months in a large cohort of patients with and without VMIA on their baseline OCT scan.

Response was determined in terms of: number of injections, central macular thickness and visual acuity.

Methods
A retrospective case notes review of treatment naïve patients with newly diagnosed CIDME. Included patients had been commenced on intravitreal Anti-VEGF injections (ranibizumab or aflibercept) at a single centre.
Inclusion criteria were: treatment naïve DME patients with a CMT of 400μ or more receiving anti-VEGF treatment with at least 12 months follow up and in whom macular OCT scans and visual acuity (VA) measurements were available within two weeks of baseline, 3, 6, 9 and 12 months.
Exclusion criteria included: previous intravitreal therapy, previous vitrectomy, cataract surgery during the follow-up period, concurrent eye conditions affecting vision or CMT.

Results
119 eyes met the inclusion criteria and underwent analysis. Groups were comparable in their baseline demographics. Baseline CMT measurements were comparable at baseline (417μ and 430μ in the No-VMIA and VMIA groups respectively) and improved to approximately 300μ in both groups. From 6 months CMT continued to improve in the no-VMIA while progressively deteriorating in the VMIA group. Change in CMT was statistically different at 12 months between the 2 groups (108μ and 79μ, p= 0.04). There was a mean of 7 injections after 12 months.

Conclusion
Our study has shown a 46% incidence of VMIA amongst patients newly diagnosed with centre involving DME undergoing treatment with anti-VEGF injections. We have also demonstrated a significant difference in CMT and VA response to anti-VEGF treatment in patients with and without VMIA. Initial response was similar between the 2 groups up until 6 months. From 6 to 12 months significant differences in treatment response emerged.
Differences in clinical response between patients with and without VMIA may help guide further prospective controlled studies and optimise treatment strategies.
Association of problems, coping styles, and preferred online activity with depression, anxiety, and other psychological disorders in Turkish adolescents diagnosed with chronic kidney disease
Authors: Kandemir Ibrahim , Gudek Kemal , Sahin Aylin Yetim , Aksakal Melike Tugrul , Kucuk Elif , Yildirim Zeynep Nagehan Yuruk , Yilmaz Alev , Nayir Ahmet , Bas Firdevs 
Published: May 2024

Abstract
Background
To assess depression, anxiety, and other psychological disorders in adolescents with chronic kidney disease (CKD) and determine the significant factors and the effect of digital media use on its scores among these patient groups.

Methods
The study was conducted as a cross-sectional study and included 84 adolescents with CKD and 68 healthy controls. The participants completed the Revised Child Anxiety and Depression Scale (RCADS). We recorded their age, gender, the most problematic issue in their lives, coping methods with problems, and online applications they prefer in their leisure time.

Results
Elevated rates (scores > 70) of separation anxiety, panic disorder, obsession, depression, total anxiety, and total depression scales were statistically higher in the CKD group. Separation anxiety, panic disorder, obsession, total anxiety, and total depression scales were higher in girls, and panic disorder, obsession, depression, total anxiety, and total depression scores were higher in younger ages in multivariate analysis. In the CKD group, family issues/problems increased panic disorder, obsession, depression, total anxiety, and total depression scales. Crying in tears/yelling response in children while facing a problem was associated with increased separation anxiety and social phobia rates. Also, preferring video applications was associated with separation anxiety and messaging applications with depression, total anxiety, and total depression.

Conclusions
Adolescents with CKD are at risk for depression, anxiety, obsession, and panic disorders. Also, crying in tears/yelling response may be at greater risk for anxiety among CKD adolescents. Early psychiatric evaluation and routine psychiatric follow-ups initiated early may improve the mental health of this vulnerable population.

Graphical Abstract
Epithermal Ag–Au mineralization at Galim-Legalgorou, Cameroon Volcanic Line: insights from alteration mineralogy and mineral chemistry of electrum and sphalerite
Authors: Ngang Terence Cho , Suh Cheo Emmanuel , Wagner Thomas , Bafon Tasin Godlove , Fusswinkel Tobias , Vishiti Akumbom 
Published: May 2024

AbstractThe Galim-Legalgorou area, located along the north-western branch of the Cameroon Volcanic Line (CVL), is known for artisanal gold mining and primary gold exploration, but the style and origin of the mineralization has not been fully described in the scientific literature. The close spatial association of the mineralization with Tertiary volcanic rocks raises the question of whether or not this is an epithermal system in a region where all previously studied gold occurrences have been classified as orogenic. In this contribution, we use ore mineral and alteration assemblage and mineral microchemistry to constrain the origin and evolution of the mineralization. Gold is alloyed mainly with Ag (max. 53.1 wt%) and show fineness values that vary 379 and 721 with an average of 455. A cumulative percentile plot of Ag concentrations in the cores of all electrum particles, and the observed step-change from Au-rich cores to more Ag-rich mantles in zoned electrum particles, suggest that the mineralization was deposited by two distinct hydrothermal fluid influxes. The observed ore mineral association-electrum, Se/Tl-acanthite, pyrite, Fe-rich sphalerite, ± galena; the measured FeS contents of sphalerite (average 23.1 mol%), and the presence of colloform banded chalcedony and hydrothermal breccia are all consistent with features of low sulfidation epithermal deposits. This study, therefore, demonstrates for the first time, the presence of significant low sulfidation epithermal Ag–Au mineralization on the CVL, an intracontinental rift region only previously known for orogenic gold mineralization.
Graphical Abstract
Anterior internal versus external fixation of unstable pelvis fractures was not associated with discharge destination, critical care, length of stay, or hospital charges
Authors: Hasegawa Ian G. , Sakka Brandan , Duong Andrew M. , Ding Li , Wong Monica D. , Gary Joshua L. , Patterson Joseph T. 
Published: May 2024

Abstract
Purpose
Determine if anterior internal versus supra-acetabular external fixation of unstable pelvic fractures is associated with care needs or discharge.

Methods
A retrospective cohort study was performed at two tertiary trauma referral centers. Adults with unstable pelvis fractures (AO/OTA 61B/61C) who received operative fixation of the anterior and posterior pelvic ring by two orthopedic trauma surgeons from October 2020 to November 2022 were included. The primary outcome was discharge destination. Secondary outcomes included intensive care unit (ICU) or ventilator days, length of stay, and hospital charges.

Results
Eighty-three eligible patients were 38.6% female, with a mean age of 47.2 ± 20.3 years and BMI 28.1 ± 6.4 kg/m2. Fifty-nine patients (71.1%) received anterior pelvis internal fixation and 24 (28.9%) received external fixation. External fixation was associated with weight-bearing restrictions (91.7% versus 49.2%, p = 0.01). No differences in demographic, functional status, insurance type, fracture classification, or injury severity measures were observed by treatment. Internal versus external anterior pelvic fixation was not associated with discharge to home (49.2% versus 29.2%, p = 0.10), median ICU days (3.0 [interquartile range (IQR) 7.8 versus 5.5 [IQR 4.3], p = 0.14, ventilator days (0 [IQR 6.0] versus 0 [IQR 2.8], p = 0.51), length of stay (13.0 [IQR 13.0] versus 17.5 (IQR 20.5), p = 0.38), or total hospital charges (US dollars 180,311 [IQR 219,061.75] versus 243,622 [IQR 187,111], p = 0.14).

Conclusions
Anterior internal versus supra-acetabular external fixation of unstable pelvis fractures was not significantly associated with discharge destination, critical care, hospital length of stay, or hospital charges. This sample may be underpowered to detect differences between groups.

Level of Evidence
Therapeutic Level IV.
Complications and survival rates of subtrochanteric fractures are similar between short and long intramedullary nail fixation and independent of weight-bearing
Authors: Cohen Daniel , Tolwin Yaakov , Toybenshlak Michael , Zinger Gershon , Peyser Amos , Levy Yadin 
Published: May 2024

Abstract
Purpose
Intertrochanteric fractures are treated surgically, allowing rapid weight-bearing to improve ambulation and lower complications and mortality. Subtrochanteric fractures are mechanically less stable and are traditionally treated with a non-weight approach and longer intramedullary nails. This study compared immediate weight-bearing versus limited weight-bearing and different intramedullary nail lengths regarding patient outcomes.

Methods
We analyzed all consecutive cases of low-energy subtrochanteric fractures treated surgically at our institution between January 2016 and November 2020. One hundred and nine patients were found. We compared nail length and immediate versus delayed weight-bearing concerning the length of stay, time to painless ambulation, time to radiographic fracture union, and revision rates. Fracture severity was also examined using the Seinsheimer classification.

Results
Length of stay and time to painless ambulation were shorter in the immediate weight-bearing group. Time to radiographic union and rate of complications were lower; however, they were not statistically significant. Conversely, no significant difference in revision rates was found. Regarding nail length, the length of stay was shorter, and the time to painless ambulation was faster in the short-length group. The rate of complications and time to union were similar. No difference in revision rate was found. Seinsheimer classification of the fracture did not influence the decision to allow weight-bearing or nail selection (p = 0.65).

Conclusions
This study demonstrates that immediate weight-bearing as tolerated and short intramedullary nails allow a quicker time for painless ambulation and hospitalization, with possibly fewer perioperative complications and faster radiographic union, without increasing complications.
Evaluation of Slow-Releasing Energy Material (SREMA) Injection for In-Situ Rock Breaking Under Uniaxial and Triaxial Loading: An Experimental Study
Authors: Manatunga U. I. , Ranjith P. G. , De Silva V. R. S. , Xu T. , Zhang D. 
Published: May 2024

AbstractPermeability enhancement of impervious rock formations is crucial for the exploitation of ore deposits, which are uneconomic using conventional mining methods. These deposits have the potential to be mined with in-situ recovery (ISR) mining methods, provided the deposit’s permeability is enhanced artificially. Slow-releasing energy material (SREMA) has been identified as a promising preconditioning technique to enhance rock permeability for ISR. However, the fracturing potential of SREMA in the presence of in-situ stresses remains under-explored in laboratory experimental research studies and needs to be assessed in detail prior to field trials. A unique confining cell was developed in this study to represent realistic confining stresses underground, and the impacts of different stress conditions on the fracturing potential of SREMA were investigated. In addition, the effects of SREMA expansion in pre-existing joints were also assessed using laboratory fracturing experiments conducted by injecting SREMA into sandstone specimens with artificially created horizontal persistent joints, which is the first attempt to the best of the author’s knowledge. Under uniaxial stress conditions (10 MPa), multiple radial cracks emerged from the borehole at the centre of the specimen, while vertical splitting of the specimen was observed due to the outward expansion of SREMA inside the joint. In comparison, under triaxial confinement (5 MPa and 10 MPa), a decrease in the damage caused to the rock mass due to the expansive pressure generated by SREMA was observed, and this was overcome by introducing multiple injection holes and stress relief holes into the rock mass.
Australian Senecio macrocarpus and S. squarrosus were suggested as apomictic but are fully sexual: evidence from flow cytometric seed screening analyses
Authors: Mráz Patrik , Ahrens Collin W. , James Elizabeth A. 
Published: May 2024

AbstractAsexual seed reproduction, apomixis, is a relatively rare reproductive strategy in angiosperms. Its rarity is probably due to evolutionary constraints that require full and synchronous expression of all the steps that modify the ancestral sexual pathway. Therefore, the documentation of any new occurrence of apomixis, especially in taxonomic groups with no previous report, should be based on thorough and solid evidence. Here, we correct the report of suggested apomictic reproduction in two endemic hexaploid species of Senecio from Australia. Based on either excess or deficiency of expected heterozygosity across loci, over-representation of several multilocus genotypes, and segregation analysis assessed using microsatellite markers, it was suggested that apomixis together with selfing could explain the observed patterns of genetic variation in perennial S. macrocarpus and annual S. squarrosus. We used flow cytometric seed screening analyses to verify the mode of reproduction of several widespread multilocus genotypes that are considered to be apomictic. These analyses revealed that all seed progeny arose by the sexual pathway, as they exhibited a constant 3:2 endosperm to embryo ploidy ratio, typical of double fertilization of a reduced embryo sac by two reduced sperm cells. Therefore, both species reproduce sexually. We suggest that the unusual genetic patterns in both allopolyploids are caused by originally low variation in the parental species, which probably also reproduce by selfing, disomic inheritance and probably also the presence of null alleles. We call for a more careful and critical interpretation of the patterns obtained, taking into account all aspects related to apomictic reproduction.
Dissecting hair breakage in alopecia areata: the central role of dysregulated cysteine homeostasis
Authors: Xu Wen , Xie Bo , Wei Dongfan , Song Xiuzu 
Published: May 2024

AbstractIn the initial stages of Alopecia Areata (AA), the predominance of hair breakage or exclamation mark hairs serves as vital indicators of disease activity. These signs are non-invasive and are commonly employed in dermatoscopic examinations. Despite their clinical salience, the underlying etiology precipitating this hair breakage remains largely uncharted territory. Our exhaustive review of the existing literature points to a pivotal role for cysteine—a key amino acid central to hair growth—in these mechanisms. This review will probe and deliberate upon the implications of aberrant cysteine metabolism in the pathogenesis of AA. It will examine the potential intersections of cysteine metabolism with autophagy, ferroptosis, immunity, and psychiatric manifestations associated with AA. Such exploration could illuminate new facets of the disease's pathophysiology, potentially paving the way for innovative therapeutic strategies.