bluuebunny/crossref_metadata_2025_split huggingface dataset:
Family dynamics in the context of elder family financial exploitation: Application of qualitative genogram analysis
Authors: Puhlman Daniel J. , Maurya Rakesh , Shigeto Aya , Murillo‐Borjas Gustavo A. , Vincenti Virginia B. 
Published: May 2024

AbstractObjectiveThis study examined family dynamics that are common in families experiencing elder family financial exploitation (EFFE) using an innovative analytical protocol, qualitative genogram analysis.BackgroundEFFE is a form of elder abuse that affects many older adults and their families. Individual factors associated with EFFE have been examined, but what is missing is a greater focus on the complex family dynamics that contribute to this violation of older family members.MethodUsing qualitative genogram analysis (QGA), a three‐step analytical protocol using family systems theory as a foundation, this study identified key relationship patterns commonly found in families where exploitation had occurred. Family genograms generated from 20 interviewees representing 20 families that reportedly experienced EFFE were used to identify common family dynamic themes.ResultsUsing QGA, we identified four relational dynamic themes across families: distance and closeness, triangulation, power and dominance, and partner influence.ConclusionThese themes illustrate that families experiencing EFFE have several similar relational dynamics, which may have contributed to creating contexts that made older family members more vulnerable to financial exploitation.ImplicationsThe findings of this study provide important indicators for practitioners (e.g., family therapists, family life educators, family attorneys) and policymakers in supporting older family members in making better financial decisions later in life.
Toward inclusive teaching: Utilizing student‐created case studies in a personal finance course
Authors: Xiao Jing Jian , Dewsbury Bryan , Azizi Mehri 
Published: May 2024

AbstractIn this qualitative study, we explore the potential of an innovative case study approach in a personal finance course among college students with the goal of making the course inclusive for students who are from economically disadvantaged families and traditionally have unsuccessful experiences in math. Students were required to create their own cases based on their unique, diverse backgrounds. Student reflections on their personal case study projects underwent thematic analyses. Our analysis documents the benefits and barriers perceived by students in this unique case study implementation, which has implications for promoting inclusive teaching in personal finance course design and delivery.
The distribution of global tidal marshes from Earth observation data
Authors: Worthington Thomas A. , Spalding Mark , Landis Emily , Maxwell Tania L. , Navarro Alejandro , Smart Lindsey S. , Murray Nicholas J. 
Published: May 2024

AbstractAimTidal marsh ecosystems are heavily impacted by human activities, highlighting a pressing need to address gaps in our knowledge of their distribution. To better understand the global distribution and changes in tidal marsh extent, and identify opportunities for their conservation and restoration, it is critical to develop a spatial knowledge base of their global occurrence. Here, we develop a globally consistent tidal marsh distribution map for the year 2020 at 10‐m resolution.LocationGlobal.Time period2020.Major taxa studiedTidal marshes.MethodsTo map the location of the world's tidal marshes at 10‐m resolution, we applied a random forest classification model to Earth observation data from the year 2020. We trained the classification model with a reference dataset developed to support distribution mapping of coastal ecosystems, and predicted the spatial distribution of tidal marshes between 60° N and 60° S. We validated the tidal marsh map using standard accuracy assessment methods, with our final map having an overall accuracy score of 0.85.ResultsWe estimate the global extent of tidal marshes in 2020 to be 52,880 km2 (95% CI: 32,030 to 59,780 km2) distributed across 120 countries and territories. Tidal marsh distribution is centred in temperate and Arctic regions, with nearly half of the global extent of tidal marshes occurring in the temperate Northern Atlantic (45%) region. At the national scale, over a third of the global extent (18,510 km2; CI: 11,200–20,900) occurs within the USA.Main conclusionsOur analysis provides the most detailed spatial data on global tidal marsh distribution to date and shows that tidal marshes occur in more countries and across a greater proportion of the world's coastline than previous mapping studies. Our map fills a major knowledge gap regarding the distribution of the world's coastal ecosystems and provides the baseline needed for measuring changes in tidal marsh extent and estimating their value in terms of ecosystem services.
Will social media celebrities drive me crazy? Exploring the effects of celebrity endorsement on impulsive buying behavior in social commerce
Authors: Shao Zhucheng , Ho Jessica Sze Yin , Tan Garry Wei‐Han , Ooi Keng‐Boon , Dennis Charles 
Published: May 2024

AbstractThis study evaluates the influence of social media celebrity endorsements on consumers' impulsive buying behavior in social commerce by extending the signaling theory and commitment‐trust theory. A self‐managed online questionnaire is designed to collect the data from 295 valid respondents and analyze it using a multi‐analytical hybrid structural equation modeling‐artificial neural network (ANN). The results reveal that relational switching alternatives and relationship benefits directly contribute to relationship commitment to social media celebrity, whereas shared value and parasocial interaction positively lead to social commerce trust; both relationship commitment and social commerce trust induce consumers' impulsive buying behavior in social commerce. From a theoretical perspective, this study enriches the components of signaling theory and commitment‐trust theory, expanding their applicability and transferability in social commerce. Moreover, this study consolidates the theoretical integration, indicating that signaling theory can be considered as an antecedent of commitment‐trust theory for triggering consumers' impulsive buying. Methodologically, adopting second‐order constructs benefits, this study captures the multidimensionality and complexity of social commerce trust and impulsive buying from the partial least squares‐ANN perspectives. In practice, this research provides valuable insights into how to better invite celebrity endorsements and build long‐term relationships with customers, as well as offers insights into countries where social commerce is lacking today. That being said, this study is constrained by its cross‐sectional research design, conducted in Malaysia. Future research endeavors should consider launching longitudinal, multicountry studies to broaden the applicability of the findings.
J‐AVENUE: A retrospective, real‐world study evaluating patient characteristics and outcomes in patients with advanced urothelial carcinoma treated with avelumab first‐line maintenance therapy in Japan
Authors: Kikuchi Eiji , Hayakawa Nozomi , Nakayama Masashi , Uno Masahiro , Nakatsu Hiroomi , Kitagawa Chiyoe , Miyake Hideaki , Yamada Takeshi , Fujita Kazutoshi , Shimoyama Hideaki , Nishihara Kiyoaki , Kobayashi Mizuki , Nakamura Motonobu , Fujimoto Kiyohide , Sano Takeshi , Nishiyama Naotaka , Ito Takayuki , Kajita Masahiro , Kobayashi Takashi , Kitamura Hiroshi 
Published: May 2024

ObjectivesThe JAVELIN Bladder 100 phase 3 trial showed that avelumab first‐line maintenance + best supportive care significantly prolonged overall survival and progression‐free survival versus best supportive care alone in patients with advanced urothelial carcinoma who were progression‐free following first‐line platinum‐based chemotherapy. We report findings from J‐AVENUE (NCT05431777), a real‐world study of avelumab first‐line maintenance therapy in Japan.MethodsMedical charts of patients with advanced urothelial carcinoma without disease progression following first‐line platinum‐based chemotherapy, who received avelumab maintenance between February and November 2021, were reviewed. Patients were followed until June 2022. The primary endpoint was patient characteristics; secondary endpoints included time to treatment failure and progression‐free survival.ResultsIn 79 patients analyzed, median age was 72 years (range, 44–86). Primary tumor site was upper tract in 45.6% and bladder in 54.4%. The most common first‐line chemotherapy regimen was cisplatin + gemcitabine (63.3%). Median number of chemotherapy cycles received was four. Best response to chemotherapy was complete response in 10.1%, partial response in 58.2%, and stable disease in 31.6%. Median treatment‐free interval before avelumab was 4.9 weeks. With avelumab first‐line maintenance therapy, the disease control rate was 58.2%, median time to treatment failure was 4.6 months (95% CI, 3.3–6.4), and median progression‐free survival was 6.1 months (95% CI, 3.6–9.7).ConclusionsFindings from J‐AVENUE show the effectiveness of avelumab first‐line maintenance in patients with advanced urothelial carcinoma in Japan in clinical practice, with similar progression‐free survival to JAVELIN Bladder 100 and previous real‐world studies, supporting its use as a standard of care.
Structured interactions between nurses and patients through intentional rounding: A scoping review
Authors: Al‐Anati Abdelrahman , Molloy Luke , Sim Jenny , Halcomb Elizabeth , Frost Steven A. 
Published: May 2024

AbstractAimTo synthesize existing literature describing the impact of intentional rounding on patient outcomes among hospitalized adults.BackgroundIntentional rounding has been described as purposeful therapeutic communication between nurses and patients during regular checks with patients using standardized protocols. Despite the widespread adoption of intentional rounding, the current understanding of the benefits of these structured interactions between nurses and patients is limited.IntroductionThe critical role of nurses in ensuring high‐quality and safe care in acute hospitals is often noted only when things go wrong. This was highlighted by investigations into the reasons for the failures in patient care at the Mid Staffordshire National Health Services.MethodsA scoping review was performed and reported using the Preferred Reporting Items for Systematic Reviews and Meta‐Analyses extension for scoping review guidelines.FindingsSixteen studies were included in the final review. Various rounding models were noted among different clinical settings; four studies reported a significant reduction in falls, and a further three reported a decrease in pressure injuries. Two studies reported a reduction in call bell usage. Significant improvements in patients’ satisfaction with intentional rounding were reported in three studies.DiscussionPromoting intentional rounding without solid evidence of its acceptability, feasibility, and suitability in different clinical settings could compromise nurses' ability to provide safe care.Conclusion and implications for nursingThere is weak evidence of the effectiveness of intentional rounding on patient outcomes because of the diversity of methods employed and methodological limitations in many studies. Our findings identify the need for robust studies to explore the acceptability and feasibility of a rounding protocol that can be implemented in different clinical settings.
Empowering learners with AI‐generated content for programming learning and computational thinking: The lens of extended effective use theory
Authors: Shanshan Shang , Sen Geng 
Published: May 2024

AbstractBackgroundArtificial intelligence–generated content (AIGC) has stepped into the spotlight with the emergence of ChatGPT, making effective use of AIGC for education a hot topic.ObjectivesThis study seeks to explore the effectiveness of integrating AIGC into programming learning through debugging. First, the study presents three levels of AIGC integration based on varying levels of abstraction. Then, drawing on extended effective use theory, the study proposes the underlying mechanism of how AIGC integration impacts programming learning performance and computational thinking.MethodsThree debugging interfaces integrated with AIGC by ChatGPT were developed for this study according to three levels of AIGC integration design. The study conducts a between‐subject experiment with one control group and three experimental groups. Analysis of covariance and a structural equation model are employed to examine the effects.Results and ConclusionsThe results show that the second and third levels of abstraction in AIGC integration yield better learning performance and computational thinking, but the first level shows no difference compared to traditional debugging. The underlying mechanism suggests that the second and third levels of abstraction promote transparent interaction, which enhances representational fidelity and consequently impacts learning performance and computational thinking, as evidenced in test of the mechanism. Moreover, the study finds that learning fidelity weakens the effect of transparent interaction on representational fidelity. Our research offers valuable theoretical and practical insights.
Clinical significance of PNO1 as a novel biomarker and therapeutic target of hepatocellular carcinoma
Authors: Roy Sanjit K. , Srivastava Shivam , McCance Caroline , Shrivastava Anju , Morvant Jason , Shankar Sharmila , Srivastava Rakesh K. 
Published: May 2024

AbstractThe RNA‐binding protein PNO1 plays an essential role in ribosome biogenesis. Recent studies have shown that it is involved in tumorigenesis; however, its role in hepatocellular carcinoma (HCC) is not well understood. The purpose of this study was to examine whether PNO1 can be used as a biomarker of HCC and also examine the therapeutic potential of PNO1 knockout for the treatment of HCC. PNO1 expression was upregulated in HCC and associated with poor prognosis. PNO1 expression was positively associated with tumour stage, lymph node metastasis and poor survival. PNO1 expression was significantly higher in HCC compared to that in fibrolamellar carcinoma or normal tissues. Furthermore, HCC tissues with mutant Tp53 expressed higher PNO1 than those with wild‐type Tp53. PNO1 knockout suppressed cell viability, colony formation and EMT of HCC cells. Since activation of Notch signalling pathway promotes HCC, we measured the effects of PNO1 knockout on the components of Notch pathway and its targets. PNO1 knockout suppressed Notch signalling by modulating the expression of Notch ligands and their receptors, and downstream targets. PNO1 knockout also inhibited genes involved in surface adhesion, cell cycle, inflammation and chemotaxis. PNO1 knockout also inhibited colony and spheroid formation, cell migration and invasion, and markers of stem cells, pluripotency and EMT in CSCs. Overall, our data suggest that PNO1 can be used as a diagnostic and prognostic biomarker of HCC, and knockout of PNO1 by CRISPR/Cas9 can be beneficial for the management of HCC by targeting CSCs.
The combination of breast cancer PDO and mini‐PDX platform for drug screening and individualized treatment
Authors: Cui Yuxin , Ran Ran , Da Yanyan , Zhang Huiwen , Jiang Meng , Qi Xin , Zhang Wei , Niu Ligang , Zhou Yuhui , Zhou Can , Tang Xiaojiang , Wang Ke , Yan Yu , Ren Yu , Dong Danfeng , Zhou Yan , Wang Hui , Gong Jin , Hu Fang , Zhao Shidi , Zhang Huimin , Zhang Chengsheng , Yang Jin 
Published: May 2024

AbstractThe majority of advanced breast cancers exhibit strong aggressiveness, heterogeneity, and drug resistance, and currently, the lack of effective treatment strategies is one of the main challenges that cancer research must face. Therefore, developing a feasible preclinical model to explore tailored treatments for refractory breast cancer is urgently needed. We established organoid biobanks from 17 patients with breast cancer and characterized them by immunohistochemistry (IHC) and next generation sequencing (NGS). In addition, we in the first combination of patient‐derived organoids (PDOs) with mini‐patient‐derived xenografts (Mini‐PDXs) for the rapid and precise screening of drug sensitivity. We confirmed that breast cancer organoids are a high‐fidelity three‐dimension (3D) model in vitro that recapitulates the original tumour's histological and genetic features. In addition, for a heavily pretreated patient with advanced drug‐resistant breast cancer, we combined PDO and Mini‐PDX models to identify potentially effective combinations of therapeutic agents for this patient who were alpelisib + fulvestrant. In the drug sensitivity experiment of organoids, we observed changes in the PI3K/AKT/mTOR signalling axis and oestrogen receptor (ER) protein expression levels, which further verified the reliability of the screening results. Our study demonstrates that the PDO combined with mini‐PDX model offers a rapid and precise drug screening platform that holds promise for personalized medicine, improving patient outcomes and addressing the urgent need for effective therapies in advanced breast cancer.
Examining variability in Naturalistic Developmental Behavioral Intervention strategy use in caregivers of children with autism spectrum disorders
Authors: Brown Hallie , Swain Deanna , Kim Hye Won , Rogers Sally , Estes Annette , Kasari Connie , Lord Catherine , Kim So Hyun 
Published: May 2024

BackgroundNaturalistic Developmental Behavioral Interventions (NDBIs) for young children with autism spectrum disorder commonly involve caregiver‐mediated approaches. However, to date, there is limited research on how caregivers' skills change, and, in turn, impact child outcomes.MethodsWe evaluated the NDBI strategy use of 191 caregivers prior to participation in NDBIs (or control groups) across multiple randomized controlled trials, using the Measure of NDBI Strategy Implementation, Caregiver Change (MONSI‐CC). Clustering analyses were used to examine caregiver variability in NDBI strategy use at intervention entry. Generalized Linear Mixed Models were used to examine changes in caregiver strategy use over the course of intervention and its impact on changes in children's social communication.ResultsUsing clustering analysis, we found that caregivers' baseline skills fit four profiles: limited, emerging, variable, and consistent/high, with few demographic factors distinguishing these groups. Caregivers starting with limited or emerging skills improved in their strategy use with intervention. Caregivers starting with more skills (consistent/high or variable) maintained higher skills over intervention. Children of caregivers in these groups who received target NDBIs improved in their social communication skills.ConclusionsResults suggested that caregiver skills improve through participation in NDBIs and may directly contribute to their children's outcomes, although more research on mediating factors is needed. Individualized approaches for caregivers and their children starting with differing skill profiles at intervention entry may be warranted.
Understanding provider use of a new clinical decision support tool aimed at reducing excess telemetry in an academic health system: A retrospective study
Authors: Hatley Maya , Korostoff‐Larsson Olivia , Malik Tahir , Blecker Saul , Eaton Kevin P. 
Published: May 2024

AbstractRationaleCardiac monitoring has often been identified as an area of overutilization and remains a limited resource in many hospitals. With the aim of reducing telemetry overuse, we added clinical decision support to our health system's telemetry order with guidance on appropriate indications for monitoring. The new order requires selection of an appropriate clinical indication.Aims and ObjectivesIn this study, we aimed to understand provider engagement with this tool by assessing concordance between selected indications within the order and the clinical presence of those conditions as documented within the patient chart.MethodsWe randomly selected 100 telemetry orders from July to October 2022 across four different hospitals at NYU Langone Health. Two independent, blinded reviewers used a structured protocol to identify documentation of actual indications for telemetry in each selected chart. We calculated the rate of concordance between indications selected in the order and indications that were determined to be clinically present on chart review.ResultsThere were 30,839 telemetry orders placed during the study timeframe. Overall concordance between the selection within the order and the actual indication was 48% (95% confidence interval [CI], 38.21%−57.79%). We observed especially low concordance rates for vague indications, such as ‘Other’, and for ‘Confirmed Stroke’, which was the only indication allowing for indefinite telemetry.ConclusionThe overall low concordance suggests a disconnect between the support tool and clinical practice. Providers are more likely to select an indication that reduces downstream work regardless of a patient's true clinical indication.
Challenges in downstream dam passage and the effect of dam removal on Atlantic salmon (Salmo salar) smolt migrations
Authors: Shry Samuel , Harbicht Andrew , Forsberg Hanna , Nilsson Anders , Hellström Gustav , Österling Martin , Calles Olle 
Published: May 2024

AbstractMigration is critical for life‐cycle completion in diadromous fish species. River connectivity is vital in facilitating these large‐scale movement events, but the extent of present‐day river fragmentation can interfere with these migrations. Fish passage solutions (FPSs) are commonly implemented with the aim of improving river connectivity. In our study, we investigated the performance of two types of FPSs, spill regimes and complete dam removal, on Atlantic salmon (Salmo salar) smolt migrations. We used acoustic telemetry to monitor migration behavior and passage success of 120 wild smolts released in three different groups/sites: one group with two dams to pass to reach the river mouth, a second group with one dam to pass, and a control group without any barriers to pass (upstream of a recently removed hydroelectric dam). Smolt passage probabilities were similar for the two studied dams (87% and 86%) but showed variation in path choice, delay times, and loss rates. Passage success was influenced by several factors, such as body size, diel period, and water temperature, but not flow. Cumulative passage success to the river mouth was 61%, with most individuals being lost within lentic river stretches, either in the forebays of hydroelectric power stations or in naturally wide river stretches. Within the recently rehabilitated river sections (post dam removal), passage speeds were significantly faster than all other sections of the river (post‐rehabilitation x¯ = 56.1 km/day) with significantly faster speeds compared to pre‐rehabilitation (pre‐x¯ = 28.0 km/day). Our findings provide valuable information on the benefits of dam removal and highlight the need for further rehabilitation measures in upriver reaches where barriers still affect downstream passage.