bluuebunny/crossref_metadata_2025_split huggingface dataset:
LC‐MS/MS determination and pharmacokinetic study of albiflorin and paeoniflorin in rat plasma after oral administration of Radix Paeoniae Alba extract and Tang‐Min‐Ling‐Wan
Authors: Tong Ling , Wan Meixu , Zhou Dandan , Gao Jun , Zhu Yonghong , Bi Kaishun 
Published: June 2010

AbstractA rapid, sensitive and selective liquid chromatography/tandem mass spectrometry method (LC‐MS/MS) was developed and validated for simultaneous determination of albiflorin and paeoniflorin in rat plasma using geniposide as an internal standard. Plasma samples were extracted by solid‐phase extraction. Chromatographic separation was carried out on a Zorbax SB‐C18 analytical column (150 × 2.1 mm × 5 µm) with 0.1% formic acid–acetonitrile (70:30, v/v) as the mobile phase. Detection was performed by multiple reaction monitoring mode using electrospray ionization in the positive ion mode. The total run time was 3.0 min between injections. The calibration curves were linear over a range of 1–1000 ng/mL for albiflorin and 2–2000 ng/mL for paeoniflorin. The overall precision and accuracy for all concentrations of quality controls and standards were better than 15%. Mean recovery was determined to be 87.7% for albiflorin and 88.8% for paeoniflorin. The validated method was successfully applied to the pharmacokinetic study of albiflorin and paeoniflorin in rat plasma after oral administration of Radix Paeoniae Alba extract and Tang‐Min‐Ling‐Wan. The pharmacokinetic parameters showed that albiflorin and paeoniflorin from Tang‐Min‐Ling‐Wan were absorbed more rapidly with higher concentrations in plasma than that from Radix Paeoniae Alba extract. The results provided a meaningful basis for evaluating the clinical applications of traditional Chinese medicine. Copyright © 2010 John Wiley & Sons, Ltd.
Anatomical study and clinical significance of the rami communicantes between cervicothoracic ganglion and brachial plexus
Authors: Song Zhan‐Feng , Sun Mao‐Min , Wu Zhan‐Yong , Xia Chun‐Lin 
Published: June 2010

AbstractThe aim of this study was to provide a detailed characterization of the rami communicantes between the stellate (or cervicothoraic) ganglion (CTG) and brachial plexus (BP). Rami communicantes of 33 fixed adult cadavers were macroscopically observed, and connection between CTG and spinal nerves and branching was investigated. In all cases, except one, the hibateral medial rami communicantes was found to be positioned symmetrically between the CTG and C7, C8 spinal nerves. Gray rami communicantes arising from the CTG joined C8, C7, C6 nerve roots on 66, 63, and 6 sides, respectively, and branched from the rami communicantes to C7, C6, C5 nerve roots lying on 51, 41, and 2 sides, respectively. Forty‐five sides of the branches from rami communicantes derived from CTG to C8 were observed to ascend through the transverse foramina of the C7 nerve. The branches from rami communicantes derived from CTG to C7 to the C6 nerve were observed ascending through the foramen transversarium of the six cervical vertebrae along with the vertebral artery and joining the C6 spinal nerve in 41 sides. Knowledge about the general distribution and individual variations of the rami communicantes between CTG and BP will be useful toward studies involving the inference of sympathetic nerve stimulation of the upper limbs and could be important for surgeons who perform surgical procedures in the cervical region or medical blockade of nerve fibers. Clin. Anat. 23:811–814, 2010. © 2010 Wiley‐Liss, Inc.
A Novel Fluorescent Probe for Retaining Galactosyltransferases
Authors: Pesnot Thomas , Palcic Monica M. , Wagner Gerd K. 
Published: June 2010

AbstractGlycosyltransferases (GTs) are a large class of carbohydrate‐active enzymes that are involved, in both pro‐ and eukaryotic organisms, in numerous important biological processes, from cellular adhesion to carcinogenesis. GTs have enormous potential as molecular targets for chemical biology and drug discovery. For the full realisation of this potential, operationally simple and generally applicable GT bioassays, especially for inhibitor screening, are indispensable tools. In order to facilitate the development of GT high‐throughput screening assays for the identification of GT inhibitors, we have developed novel, fluorescent derivatives of UDP‐galactose (UDP‐Gal) that are recognised as donor analogues by several different retaining galactosyltransferases (GalTs). We demonstrate for one of these derivatives that fluorescence emission is quenched upon specific binding to individual GalTs, and that this effect can be used as the read‐out in ligand‐displacement experiments. The novel fluorophore acts as an excellent sensor for several different enzymes and is suitable for the development of a new type of GalT bioassay, whose modular nature and operational simplicity will significantly facilitate inhibitor screening. Importantly, the structural differences between the natural donor UDP‐Gal and the new fluorescent derivatives are minimal, and the general assay principle described herein may therefore also be applicable to other GalTs and/or proteins that use nucleotides or nucleotide conjugates as their cofactor.
Influence of the Linkage between Leaving Group and Nucleoside on Substrate Efficiency for Incorporation in DNA Catalyzed by Reverse Transcriptase
Authors: Giraut Anne , Herdewijn Piet 
Published: June 2010

AbstractAn amino acid deoxyadenosine phosphoramidate and the corresponding phosphodiester congener have been synthesized and tested for primer extension by HIV‐1 reverse transcriptase. Replacement of the phosphoramidate linkage of L‐histidine–dAMP by a phosphodiester linkage was found to have a beneficial influence on the affinity of this substrate towards HIV‐1 reverse transcriptase and on the velocity of the nucleotide incorporation reaction. Modifications of the nature of the PX bond can be useful to fine‐tune the substrate properties of nucleoside triphosphate analogues. Our results also demonstrate that polymerization pausing observed during the incorporation of leaving group modified dNTPs is not caused by the nature of the linkage.
The psychiatric expert witness in the criminal justice system
Authors: Mullen Paul E. 
Published: June 2010

AbstractThis essay examines the nature of being an expert witness as a psychiatrist or a psychologist. The critiques of the psychiatrist as expert in the criminal justice systems produced by Michel Foucault, and Robert Musil provide a starting point for this study.Today's mental health experts working in the criminal justice field have an increasing burden of responsibility as a result of their wider role, and potentially greater power to harm. This requires an awareness of the dangers of misusing that power in part from misunderstanding its source. The expert's legitimacy stems from the knowledge they mediate. In psychiatry, we have an important, but limited, body of relevant quantitative scientific data coupled to a mass of qualitative observations with which we fill the gaps and construct our professional narratives. Confusing the science with the poetry makes us foolish and even more open to manipulation by authorities pursuing legal, governmental and populist agenda. The choices that face us lie between being a ‘forensicist’, tied to the legal discourse, or a being a physician, committed to mediating medical science and clinical experience. The middle ground is a slippery slope in the direction of the power of the criminal justice system. Copyright © 2010 John Wiley & Sons, Ltd.
Symmetrical and Nonsymmetrical Chromophores with Tröger’s Base Skeleton: Chiroptical, Linear, and Quadratic Nonlinear Optical Properties—A Joint Theoretical and Experimental Study
Authors: Sergeyev Sergey , Didier Delphine , Boitsov Vitaly , Teshome Ayele , Asselberghs Inge , Clays Koen , Vande Velde Christophe M. L. , Plaquet Aurélie , Champagne Benoît 
Published: June 2010

AbstractWe report on the novel chiral push–pull chromophores derived from 6H,12H‐5,11‐methanodibenzo[b,f][1,5]diazocine (Tröger’s base skeleton). The synthesis of symmetrical chromophores featuring two identical acceptors, as well as the synthesis of unsymmetrical chromophores featuring only one acceptor is given. Symmetrical chromophores were prepared in the enantiomerically pure form and their chiroptical properties were investigated. Second‐order nonlinear optical (NLO) properties of new chromophores were investigated with the aid of hyper‐Rayleigh scattering (HRS). The detailed theoretical analysis of the second‐order NLO properties of the chromophores was also undertaken. The joint theoretical and experimental studies of chromophores derived from Tröger’s base skeleton, in comparison with benchmark chromophores featuring a dimethylamino group as the donor, provided insight into the relationship between the structure of the new chromophores and their NLO properties.
Iridium‐Catalyzed CH Activation versus Directed ortho Metalation: Complementary Borylation of Aromatics and Heteroaromatics
Authors: Hurst Timothy E. , Macklin Todd K. , Becker Maike , Hartmann Eduard , Kügel Wolfgang , Parisienne‐La Salle Jean‐Christophe , Batsanov Andrei S. , Marder Todd B. , Snieckus Victor 
Published: June 2010

AbstractSystematic studies are presented demonstrating the complementarity of directed ortho metalation (DoM) and Ir‐catalyzed strategies for the provision of borylated aromatics and their subsequent Suzuki–Miyaura coupling reactions. A new concept, the use of the TMS group, readily introduced by DoM, as a latent regiodirective moiety to overcome the otherwise problematic production of isomeric borylated product mixtures is presented. Additional electrophile‐induced ipso‐deborylation and DoM reactions of the Bpin products are described.
Formation of the Distinct Redox‐Interrelated Forms of Nitric Oxide from Reaction of Dinitrosyl Iron Complexes (DNICs) and Substitution Ligands
Authors: Lu Tsai‐Te , Chen Chih‐Hao , Liaw Wen‐Feng 
Published: June 2010

AbstractRelease of the distinct NO redox‐interrelated forms (NO+, .NO, and HNO/NO−), derived from reaction of the dinitrosyl iron complex (DNIC) [(NO)2Fe(C12H8N)2]− (1) (C12H8N=carbazolate) and the substitution ligands (S2CNMe2)2, [SC6H4‐o‐NHC(O)(C5H4N)]2 ((PyPepS)2), and P(C6H3‐3‐SiMe3‐2‐SH)3 ([P(SH)3]), respectively, was demonstrated. In contrast to the reaction of (PyPepS)2 and DNIC 1 in a 1:1 stoichiometry that induces the release of an NO radical and the formation of complex [PPN][Fe(PyPepS)2] (4), the incoming substitution ligand (S2CNMe2)2 triggered the transformation of DNIC 1 into complex [(NO)Fe(S2CNMe2)2] (2) along with N‐nitrosocarbazole (3). The subsequent nitrosation of N‐acetylpenicillamine (NAP) by N‐nitrosocarbazole (3) to produce S‐nitroso‐N‐acetylpenicillamine (SNAP) may signify the possible formation pathway of S‐nitrosothiols from DNICs by means of transnitrosation of N‐nitrosamines. Protonation of DNIC 1 by [P(SH)3] triggers the release of HNO and the generation of complex [PPN][Fe(NO)P(C6H3‐3‐SiMe3‐2‐S)3] (5). In a similar fashion, the nucleophilic attack of the chelating ligand P(C6H3‐3‐SiMe3‐2‐SNa)3 ([P(SNa)3]) on DNIC 1 resulted in the direct release of [NO]− captured by [(15NO)Fe(SPh)3]−, thus leading to [(15NO)(14NO)Fe(SPh)2]−. These results illustrate one aspect of how the incoming substitution ligands ((S2CNMe2)2 vs. (PyPepS)2 vs. [P(SH)3]/[P(SNa)3]) in cooperation with the carbazolate‐coordinated ligands of DNIC 1 function to control the release of NO+, .NO, or [NO]− from DNIC 1 upon reaction of complex 1 and the substitution ligands. Also, these results signify that DNICs may act as an intermediary of NO in the redox signaling processes by providing the distinct redox‐interrelated forms of NO to interact with different NO‐responsive targets in biological systems.
ChemInform Abstract: Synthesis and Structure of Ag7M6F31 (M: Zr, Hf, Ce).
Authors: Koller D. , Mueller B. G. 
Published: June 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis and Crystal Structures of Ln2Al3Si2 and Ln2AlSi2 (Ln: Y, Tb—Lu).
Authors: Kranenberg C. , Mewis A. 
Published: June 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Sol—Gel Preparation of Lead Zirconate Titanate Powders and Ceramics: Effect of Alkoxide Stabilizers and Lead Precursors.
Authors: Wu Aiying , Vilarinho Paula M. , Miranda Salvado Isabel M. , Baptista Joao L. 
Published: June 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Chemical Vapor Transport of Intermetallic Systems. Part 10. Chemical Transport of Copper/Gallium and Silver/Gallium Phases.
Authors: Plaggenborg T. , Binnewies M. 
Published: June 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Chemical Transport of Solid Solutions: Transport Phenomena in the Co3O4/CoGa2O4 System.
Authors: Patzke Greta R. , Koepke Juergen , Binnewies Michael 
Published: June 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Gas‐Phase and Solution Basicities of Some Alkyl 2,6‐Dialkylphenyl Ketones: A Comparative Analysis.
Authors: Dell'Erba Carlo , Gruttadauria Michelangelo , Mugnoli Angelo , Noto Renato , Novi Marino , Occhiucci Giorgio , Petrillo Giovanni , Spinelli Domenico 
Published: June 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Catalytic Asymmetric and Chemoselective Aerobic Oxidation: Kinetic Resolution of sec‐Alcohols.
Authors: Masutani Kouta , Uchida Tatsuya , Irie Ryo , Katsuki Tsutomu 
Published: June 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Salen as a Chiral Activator: anti versus syn Switchable Diastereoselection in the Enantioselective Addition of Crotyl Bromide to Aromatic Aldehydes.
Authors: Bandini Marco , Cozzi Pier Giorgio , Umani‐Ronchi Achille 
Published: June 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Free Radical Chemistry. Part 10. Addition of Acyclic and Cyclic Alkanes to Hexafluoropropene.
Authors: Chambers Richard D. , Fuss Robert W. , Spink Robert C. H. , Greenhall Martin P. , Kenwright Alan M. , Batsanov Andrei S. , Howard Judith A. K. 
Published: June 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Free Radical Chemistry. Part 11. Additions of Cyclic and Acyclic Alcohols and Diols to Hexafluoropropene.
Authors: Chambers Richard D. , Diter Patrick , Dunn Stephen N. , Farren Christopher , Sandford Graham , Batsanov Andrei S. , Howard Judith A. K. 
Published: June 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Studies with Functionally Substituted Heteroaromatics: A New Route for Synthesis of Pyridazino[2,3‐a]quinazoline and Pyridazino‐6‐imine Derivatives.
Authors: Al‐Zaydi Khadijah M. , Hafez Ebtisam A. , Elnagdi Mohamed H. 
Published: June 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Cross Condensation Reactions of Ethyl Cyanoacetate with Some Ketomethylene Compounds: Diastereoselective Synthesis of Z‐2‐(Cyanoethoxycarbonyl)methylene‐1,2‐dihydropyridine and Z‐2‐(Cyanoethoxycarbonyl)methylene‐2H‐pyran Derivatives.
Authors: Talapatra Sunil K. , Mandal Kabita , Biswas Kallolmay , Mandal Sudipta , Talapatra Bani 
Published: June 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Microwave Heating in Organic Synthesis: Decarboxylation of Malonic Acid Derivatives in Water.
Authors: Zara Cynthia Lynn , Jin Thomas , Giguere Raymond J. 
Published: June 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis of Halo Compounds from Propargylamines.
Authors: Turgunov E. , Sadikov M. K. , Nurnakhmedova T. , Sirlibaev T. S. 
Published: June 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Organotin Hydride Catalyzed Radical Desulfurization of Thionoesters and Thionolactones.
Authors: Jang Doo Ok , Song Seong Ho 
Published: June 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis of Highly Substituted Diphenylacetamides and Diphenylsulfonamides by the Goldberg Coupling Reaction.
Authors: Raposo M. Manuela M. , Pereira Alexandra M. B. , Oliveira‐Campos Ana M. F. , Shannon Patrick V. R. 
Published: June 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: A New Novel and Practical One‐Pot Methodology for Conversion of Alcohols to Amines.
Authors: Vidya Sagar Reddy G. , Venkat Rao G. , Subramanyam R. V. K. , Iyengar D. S. 
Published: June 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Improved Nickel‐Catalyzed Cross‐Coupling Reaction Conditions Between ortho‐Substituted Aryl Iodides/Nonaflates and Alkylzinc Iodides in Solution and in the Solid‐Phase.
Authors: Jensen Anne Eeg , Dohle Wolfgang , Knochel Paul 
Published: June 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: A Mild and Efficient Method for the Deoxygenation of α,β‐Epoxyketones to Enones.
Authors: Rana Kalyan Kumar , Roy Subhas Chandra 
Published: June 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: A Convenient and Scalable Procedure for Removing the Fmoc Group in Solution.
Authors: Sheppeck II James E. , Kar Heidi , Hong Hui 
Published: June 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: A Synthetic Equivalent of 3,5‐Dimethoxyphenyl Lithium. A Facile Route to 5‐Substituted Resorcinols.
Authors: Kraus George A. , Zeng Yuan 
Published: June 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Transformations of exo‐6‐Bromo‐syn‐7‐bromo(chloro)methylsulfonyl‐endo‐6‐phenylbicyclo [3.1.1]heptane under Conditions of Ramberg—Baecklund Reactions.
Authors: Vasin V. A. , Romanova E. V. , Kostryukov S. G. , Razin V. V. 
Published: June 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.