bluuebunny/crossref_metadata_2025_split huggingface dataset:
Research on the Application of Multidimensional Collaborative Landscape Design Course Teaching in Revolutionary Historical and Cultural Landscape Design--Taking Zhuhai as an Example
Authors: Yang Bixiang 
Published: May 2024

Abstract
This study explores a multidimensional collaborative landscape design course, detailing its unique collaborative teaching framework within the context of Zhuhai’s transformative historical and cultural landscape. It employs a comprehensive set of metrics, including teaching objectives and methodologies, to assess the course’s effectiveness. The relevance of variations among elements was evaluated through statistical analyses, including T-tests, F-tests, and correlation studies. Further, the study examined participant satisfaction, visual appeal, and aesthetic impact of the “red cultural” landscape design. Results indicated that the average teaching evaluation scores surpassed 4 points, and satisfaction levels with the red cultural landscape design approached 80%, reflecting a beneficial influence on educational outcomes. This research contributes novel insights to the development of landscape evaluation systems in cultural tourism settings and offers theoretical advancements for implementing multidimensional collaborative teaching strategies in landscape design.
Machine-learning-based analysis of biomedical time-series data: the monitoring and prediction of disease progression
Authors: Zhang Xinren 
Published: May 2024

Abstract
This study examines the spatial and temporal patterns of influenza and malaria incidence using an ARMA-BP combination model. The approach employs the dynamic series method to identify epidemic patterns of these diseases while assessing serial autocorrelation coefficients, performing randomness tests, and establishing a forecasting model. Additionally, it evaluates the impact of seasonal and meteorological factors on the epidemiology of influenza and malaria to ascertain the model’s efficacy in predicting incidence rates and trends. The findings indicate that the peak period for influenza incidence typically occurs during the transition from winter to spring, specifically between weeks 2 and 14. The correlation coefficients between temperature variables and malaria incidence generally ranged from 0.7 to 0.9. The ARMA-BP model demonstrated robust short-term predictive capabilities for influenza, showing a high degree of concordance in predictions for 2021 and 2022, though it performed less satisfactorily for 2023. For malaria, the predicted and actual incidence trends were largely consistent, with prediction errors consistently below 0.01. Consequently, this underscores the need for enhanced data collection on factors influencing disease dynamics. This research provides valuable decision-making support, scientific insights, and theoretical guidance for enhancing disease monitoring and prediction strategies.
Application of statistical models based on survival analysis in the assessment of cancer prognosis
Authors: Zhang Xinren 
Published: May 2024

Abstract
For cancer patients, accurate estimation of patients’ survival time facilitates medical personnel to formulate treatment measures while avoiding the negative impact of poor treatment programs. In this paper, in order to overcome the limitations of the single-factor survival analysis model, the Cox proportional risk analysis method is proposed and combined with Lasson regression analysis at the same time to establish a cancer prognosis risk assessment model. After extracting and preliminary screening cancer gene features and then analyzing the correlation between the features, the most important indicators used for cancer prognosis assessment were summarized. In the correlation analysis of cancer indicators, the number of factors showing a positive correlation with lncRAN in cancer cells was 136, and the number of negative correlations was 92. The correlation coefficients ranged from −2.65 to 0.52. After the ROC curve evaluated the predictive risk model, the areas of 1-, 3-, and 5-year OS curves of cancer patients were 0.7854, 0.8462, and 0.7855, respectively. The number of deaths increased gradually along with the increase in the risk scores, and the model predicted the results more accurately.
Study on the environmental status of Shichigou Village, Rim yu, Qinling Mountains
Authors: Lin Hongyi 
Published: May 2024

Abstract
The article illustrates and analyzes the environmental features of Rim Valley and Shifangou Village in the northern Qinling Mountains. Firstly, the ecological characteristics of Rim Valley in terms of elevation, slope, slope direction, river network, and land use classification were summarized through Arcgis mapping so as to overview the environment of Shifangou village as a sub-body of the Rim Valley; secondly, the environmental data of Shifangou village were obtained through field research, and the village landscape evaluation was conducted according to the local conditions, and the methods used were hierarchical analysis and villagers’ rating method, which were based on four dimensions of village environment: ecological elements, production elements, life elements, and feelings elements. The technique used is hierarchical analysis and villagers’ rating method, which mainly evaluates the rural environment in four dimensions, namely, rural ecological elements, rural production elements, rural life elements, and rural feeling elements, and expands on the basis of the “Three Lives” research method, focusing on people’s feelings towards the countryside, so as to arrive at the basic situation of the environment in Shifangou Village.
Research on Gear Synthesis of Automatic Transmission
Authors: Xue Huiling , Li Lijian 
Published: May 2024

Abstract
The lever method facilitates a straightforward analysis of the motion dynamics of an automatic transmission under various gear settings, offering a simple and intuitive approach to examining planetary gear transmissions. Specifically, the equivalent lever diagram for a parallel-double planetary gear transmission comprises four component points. From a control perspective, a transmission system with two planetary rows can accommodate up to two reduction gears, one direct gear, one overdrive gear, and one reverse gear. In contrast, the equivalent lever diagram for a parallel three-planetary gear transmission includes five component points, with such systems typically supporting up to three reduction gears, one direct gear, two overdrive gears, and two reverse gears. This methodological approach underscores the lever diagram’s utility in delineating the functional capabilities of complex transmission systems.
A Diversified Teaching Model of Business English in Multimodal Perspective
Authors: Gong Shengjie 
Published: May 2024

Abstract
Traditional business English pedagogy has predominantly relied on an unimodal teaching approach, which often fails to satisfy the demands of contemporary talent development. Addressing this inadequacy, this study advocates for the establishment of a diversified teaching model from a multimodal perspective. Furthermore, it introduces a comprehensive evaluation framework designed to assess the efficacy of various business English teaching methodologies. This evaluation model employs the K-means clustering algorithm for data segmentation, utilizes both positive and negative indicators for constructing metrics, and integrates the fuzzy comprehensive evaluation method with gray system theory for robust analysis. The research was conducted at AB University, where experimental and control groups were established to critically assess the effectiveness of the diversified teaching approaches. Results indicate that the experimental group’s average business English score was 53.1, which is significantly higher by 10.94 points than that of the control group (P<0.01). Moreover, notable differences were observed in students’ classroom behaviors, including course engagement, responsiveness to teachers, and learning attitudes, all showing highly significant improvements in the experimental group (P<0.01). Similarly, in terms of teaching quality, the experimental group significantly outperformed the control group across the dimensions of content design, lecture delivery, and overall teaching impact (P<0.01). This study not only underscores the effectiveness of the proposed diversified business English teaching model but also provides a theoretical and empirical foundation for its evaluation.
Design and Timeliness Analysis of English Teaching Models in Colleges and Universities Combining Perceptual and Behavioral Correlation Algorithms
Authors: Chen Lingyan 
Published: May 2024

Abstract
With the continuous development of education, the way English education presents itself has become more and more complex and diversified. This study focuses on the problem of low quality and efficiency in English teaching, and it centers on the characteristics of perception and behavior in English teaching. To collect data on perception and behavior in English teaching, we first utilize the association rule method in data mining technology. Then, we introduce the technology acceptance model and design the English teaching model of “Knowing and Doing” by combining the collected data. The timeliness of the English teaching model in practice is investigated using the fuzzy comprehensive evaluation method on this basis. The English teaching model designed in this paper improved by 10.688 points compared to the previous one, and the improvement was 1.307 points in the third month. In the correlation rule analysis, it can be seen that the probability of English grade A (90 or above) is 70.4% when perceived ease of use, usefulness, and learning behavior occur simultaneously. This study proves the feasibility of the English teaching model in this paper and provides a useful reference for the development of the English teaching model in the future.
Computer simulation of a solar multi-effect distillation multi-stage flash effluent purification system
Authors: Cui Xiajing , Shou Haofang 
Published: May 2024

Abstract
This study integrates multi-effect distillation (MED), multi-stage flash (MSF) evaporation, and solar interface evaporation technologies to enhance water purification processes. We evaluate the material and performance of interface evaporators, with a particular focus on managing the energy balance in solar water evaporation. The research further develops thermal regulation in photothermal materials to maximize light absorption, minimize heat loss, and speed up steam conversion. We employ a novel approach using corn starch and ionic liquid-modified silica hydrogels, noted for their hydrophilicity and broad-spectrum light absorption. The goal is to assess these hydrogels for photothermal conversion efficiency and salt resistance, examining their evaporation performance across various media—pure water, highly saline water, and oily wastewater—and their effectiveness in purifying industrial sewage. Monomer [VEIm]Br and cross-linking agent polymerization occurred to prepare the obtained SiO
2 – PILs.Ag / PPy / SiO
2
– PILs surface of polypyrrole and Ag particles presenting a three-dimensional porous structure is able to enhance the light absorption performance, between 200-2500 nm range of light absorption rate as high as 90%. Experiments proved the introduction of ionic liquid grafted silica on the introduction of the mechanism to improve the thermal insulation and salt resistance for the actual wastewater purification to provide a strategy.
Does the trimline extension and attachment size affect maxillary arch expansion in clear aligner therapy ? A finite element study
Authors: Karsli Nurver , Yildirim Fazilet , Dingiloğlu Arda , Özsoy Ömür Polat 
Published: May 2024

Abstract

Objective
Using finite element analysis (FEA), the aim of the present study was to evaluate the effects of different aligner trimline extensions and attachment sizes on maxillary first and second molars under expansive forces delivered by clear aligner therapy

Methods
The study utilised 3 mm and 4 mm horizontal rectangular attachments on the maxillary first and second molars. Two main models were created: a High and Flat Trimline Aligner (HTLA), and a Low and Flat Trimline Aligner (LTLA). Six distinct model variations were created for the analysis: (1) LTLA and no attachment (NA), (2) LTLA and 3 mm horizontal rectangular attachment (3HA), (3) LTLA and 4 mm horizontal rectangular attachment (4HA), (4) HTLA and NA, (5) HTLA and 3HA, (6) HTLA and 4HA.

Results
In all models, the crowns of the maxillary molars exhibited buccal displacement, whereas the root displayed palatal displacement. The LTLA-NA model had the greatest displacement of all models, whereas the HTLA-4HA model had the lowest displacement. The greatest PDL stress value was identified in the coronal third region of the palatal root of the molars.

Conclusion
Buccal tipping of the molars was observed during aligner expansion in all models. By increasing the attachment size and heightening the aligner trimline extension, the occurrence of buccal tipping was significantly reduced.
Access equity: key questions and challenges - A report from the 1st workshop of the European Haemophilia Consortium (EHC) Think Tank Workstream on Access Equity
Authors: Skouw-Rasmussen Naja , Savini Laura 
Published: May 2024

Abstract

Introduction
The European Haemophilia Consortium (EHC) Think Tank Workstream on Access Equity aims to identify and address the key challenges to ensuring access equity to healthcare services for people with rare diseases. In this context, access refers to the ability to benefit from any given aspect of treatment and care; equity refers to being ‘fair and impartial’ in providing access.

Identifying key challenges
At the first virtual workshop of the Access Equity Workstream, participants representing a wide range of stakeholders, including healthcare providers, patient groups, research, and industry, shared their perspectives to identify the key challenges to achieving access equity. It was agreed to prioritise three challenges: 1. Patient journey and pathways; 2. Behavioural change, mindsets and incentives; 3. Budget and resources. The Iceberg Model was used to identify the factors (events, patterns, structures, and mental models) which should be prioritised for future discussions about potential interventions.

Summary
From an access equity viewpoint, the key events in the patient journey and pathways that need to be addressed are access to diagnosis, screening and treatment, taking account of the considerable national, regional and local variation in the availability of specialist expertise, genetic testing and counselling. There will be debate about sharing limited budgets to treat small numbers of people with rare disorders with gene therapy, compared to treating much larger numbers of patients with common diseases with cheaper drugs. In terms of behavioural change, mindset and incentives, there is a misalignment of personal, collective, organisational and national needs. Among providers, the ‘savings mindset’ is counterproductive for access equity, and short-termism may result in a restricted allocation of funding for innovative and preventive therapies. Industry mindset is largely transactional instead of outcomes-based and the patient community tends to focus on specific diseases instead of the wider implications for the provision of healthcare services and for society. Budgets and resources are key to access equity; reduced/delayed access to expensive new drugs for rare diseases such as haemophilia is a major issue. Cost-effectiveness prioritisation tools used for health technology assessments (HTAs) do not take into account data from small populations, leading to cost-effectiveness ratios that exceed accepted thresholds, and treatments restricted to subgroups of patients within an approved indication. Benchmarking international pricing, service centralisation and cross-border cooperation for delivery of gene therapy need to be addressed if access equity is to be achieved.
Future Care Pathways – A report from the 1st workshop of the EHC Think Tank Workstream on Future Care Pathways
Authors: Skouw-Rasmussen Naja , Savini Laura 
Published: May 2024

Abstract

Introduction
A care pathway is defined as “a complex intervention for the mutual decision-making and organisation of care processes for a well-defined group of patients during a well-defined period.” The European Haemophilia Consortium (EHC) established a Think Tank Workstream on Future Care Pathways to identify and address key challenges in shaping future pathways that meet the needs of people with rare diseases while remaining practicable and affordable to healthcare providers in countries with different budgets and resources. This workstream is particularly timely as the introduction of innovative therapies is adding to the complexity of care pathways in some rare conditions.

Identifying key challenges
During the first virtual workshop of the Future Care Pathways Workstream on 14 February 2023, stakeholders, including healthcare providers, patient groups, researchers, and industry representatives, agreed to focus on four workable themes/challenges: 1. Prioritisation (cost and evidence); 2. Agreeing on a baseline; 3. Digital health; 4. Fragmentation of healthcare.

Summary

Prioritisation relates to economic and financial challenges in justifying the optimisation of a care pathway for a rare disease within the context of other healthcare priorities. Currently, there is too much emphasis on costs to healthcare systems, and not enough on real-life patient experience and indirect costs to patients and their families. Innovation in pathways is generally considered unaffordable, and cost-effectiveness models are difficult to apply to rare diseases. Agreeing on a baseline for a minimum standard of care in a pathway should take into account variability in patient needs, agency and healthcare system resources. A baseline needs to be agreed upon for each stage of a pathway: first clinical presentation, diagnosis, treatment, and monitoring and follow-up. Lack of awareness, gender and resource inequalities and gaps in evidence are among the issues that need to be addressed. Digital health holds promise but also brings challenges for future care pathways and must be considered from the viewpoint of all major stakeholders: patients, healthcare providers, tech companies and payers. Digital health systems are often developed in silos and do not allow for effective integration and sharing of data. Collaboration from the beginning is essential to the successful integration of digital tool as in healthcare. Fragmentation of healthcare can arise because people with rare diseases may access care pathways through multiple entry points in primary and secondary care, and they may not experience holistic care that takes account of all their needs. Poor communication at multiple levels (e.g. between clinical stakeholders and between clinicians and patients) is a common problem leading to inadequate treatment and care. Fragmentation may also arise when care pathways do not allow for a patient’s evolving needs when he/she is already on a pathway.
Living, Caring, Learning - Thinking outside the box to solve care challenges in a rare blood disorder
Authors: Hibner Sandra 
Published: May 2024

Abstract
A specialist nurse for over 20 years, Sandra reflects on her experience of finding ways to deliver effective care for a young girl with a very rare clotting disorder. Symptoms of the girl’s disorder were evident from birth and through an emergency use request Sandra and the care team enabled her family to access a treatment that at the time was in clinical trial. Poor venous access meant there was a need to adapt how treatment was administered and she worked with the girl’s parents to ensure that she was treated effectively. Alongside educating the parents, Sandra highlights the importance of her role in educating co-workers and other hospital staff likely to come into contact with the girl, to ensure that she always had access to timely and appropriate care. She also reflects on other instances where thinking creatively enabled patients in her care access to treatments that may not otherwise have been accessible. Now retired, Sandra continues to be involved in advocacy for people with bleeding disorders.
Living, Caring, Learning - Building family relationships in haemophilia care
Authors: Shoemark Robyn 
Published: May 2024

Abstract
With over 35 years’ experience of paediatric nursing, almost half of which she has spent in haemophilia care, Robyn reflects on the importance of taking a family-focused approach and engaging with parents and caregivers. She describes her experience of providing care for a family with two boys with severe haemophilia A and inhibitors, and how listening to and working closely with the parents enabled good outcomes. Robyn points to the central role of nursepatient relationship in haemophilia care but highlights the importance of ensuring that this close therapeutic relationship remains professional.
Exploring patient and clinician perspectives on the benefits and risks of emerging therapies for the treatment of haemophilia: a qualitative study
Authors: Spoors John , Payne Katherine , Wright Stuart , Horsley Will , Bell Sadie , Cairns John 
Published: May 2024

Abstract

Background
Enhanced horizon scanning for emerging treatments has identified that both haemophilia A and haemophilia B pathways will be enriched with a range of new medicines with varying benefit-risk profiles. Patient and clinician views on the balance of the benefits and risks associated with emerging therapies will affect their use for the treatment of haemophilia, while also introducing the need for effective communication strategies to enable informed patient-clinician decision-making.

Aim
This study aimed to explore patient and clinician views on the perceived benefits and risks of emerging therapies for the treatment of haemophilia. The study also aimed to gain insight into clinician-patient communication on benefit and risk and how this shapes decision-making on new therapeutic options.

Methods
Qualitative methods, using online focus groups and one-to-one interviews, were guided by a defined set of questions. Data were collected in 2022 and 2023 from a sample of adult patients identified through the national patient group (The Haemophilia Society) and clinicians identified through the NHS England Clinical Reference Group (CRG) and HAEM-NET. Data were analysed thematically.

Findings
Seven patients and ten clinicians (seven consultant haematologists; three advanced nurse practitioners) participated. Five summary themes were identified, three of which related to clinician-patient communication: (i) active vs. passive patients; (ii) health literacy; (iii) external factors. One theme related to gene therapy perspectives on benefit-risk, and one theme concerned the legacy of the infected blood scandal.

Conclusion
There remains scepticism about gene therapy across all research participant groups, which suggests that uptake is likely to be relatively slow, with divergence anticipated between haemophilia A and B. Treatment decision-making and benefit-risk discussions are complex and multifaceted issues which in haemophilia are heavily influenced by the infected blood scandal. Clinicians frame treatment decision-making which necessitates the requirement for benefit-risk training and high-quality tailored patient gene therapy information materials.