bluuebunny/crossref_metadata_2025_split huggingface dataset:
Efficacy and safety of robotic radical hysterectomy in cervical cancer compared with laparoscopic radical hysterectomy: a meta-analysis
Authors: Dai Zhen , Qin Fuqiang , Yang Yuxing , Liang Weiming , Wang Xiao 
Published: May 2024

IntroductionRobotic radical hysterectomy (RRH) is a newly developed minimally invasive surgery that has been suggested as a substitute for laparoscopic radical hysterectomy (LRH). This meta-analysis aims to assess the clinical efficacy and safety of robot-assisted radical hysterectomy (RRH) for cervical cancer.Materials and methodsA systematic search was conducted in four databases (Medline, Embase, Web of Science, and CENTRAL) for studies comparing the utilization of RRH and LRH in the treatment of cervical cancer. The search included articles published from the inception of the databases up until July 18, 2023. Meta-analyses were conducted to assess several surgical outcomes, including operation time, estimated blood loss, length of hospital stay, pelvic lymph nodes, positive surgical margin, total complications, one-year recurrence rate, one-year mortality, and one-year disease-free survival rate.ResultsSix studies were included for meta-analysis. In total, 234 patients were in the RRH group and 174 patients were in the LRH group. RRH had significantly longer operative time (MD=14.23,95% CI:5.27~23.20, P=0.002),shorter hospital stay (MD= -1.10,95% CI:-1.43~0.76, P &lt;0.00001),more dissected pelvic lymph nodes(MD=0.89,95%CI:0.18~1.60, P =0.01) and less blood loss(WMD = -27.78,95%CI:-58.69 ~ -3.14, P=0.08, I2 = 80%) compared with LRH. No significant difference was observed between two groups regarding positive surgical margin (OR = 0.59, 95% CI 0.18~2.76, P=0.61), over complications (OR = 0.77, 95% CI, 0.46-1.28, P=0.31), one-year recurrence rate (OR = 0.19, 95% CI 0.03-1.15, P=0.13), one-year mortality rate (OR = 0.19, 95% CI 0.03-1.15, P=0.07) and disease-free survival at one year (OR = 1.92, 95% CI 0.32-11.50, P=0.48).ConclusionRRH is an increasingly popular surgical method known for its high level of security and efficiency. It has many benefits in comparison to LRH, such as decreased blood loss, a higher quantity of dissected pelvic lymph nodes, and a shorter duration of hospitalization. Further multicenter, randomized controlled trials with extended follow-up durations are necessary to conclusively determine the safety and efficacy of RRH, as no significant differences were observed in terms of positive surgical margin, postoperative complications, 1-year recurrence, 1-year mortality, and 1-year disease-free survival.Systematic Review RegistrationPROSPERO, identifier CRD42023446653
Molecular profiling of metastatic breast cancer and target-based therapeutic matching in an Asian tertiary phase I oncology unit
Authors: Walsh Robert John , Ong Rebecca , Cheo Seng Wee , Low Peter Q.J. , Jayagopal Aishwarya , Lee Matilda , Ngoi Natalie , Ow Samuel G. , Wong Andrea L.A. , Lim Siew Eng , Lim Yi Wan , Heong Valerie , Sundar Raghav , Soo Ross A. , Chee Cheng Ean , Yong Wei Peng , Goh Boon Cher , Lee Soo Chin , Tan David S.P. , Lim Joline S.J. 
Published: May 2024

IntroductionMolecular profiling of metastatic breast cancer (MBC) through the widespread use of next-generation sequencing (NGS) has highlighted actionable mutations and driven trials of targeted therapy matched to tumour molecular profiles, with improved outcomes reported using such an approach. Here, we review NGS results and treatment outcomes for a cohort of Asian MBC patients in the phase I unit of a tertiary centre.MethodsPatients with MBC referred to a phase I unit underwent NGS via Ion AmpliSeq Cancer Hotspot v2 (ACH v2, 2014–2017) prior to institutional change to FoundationOne CDx (FM1; 2017–2022). Patients were counselled on findings and enrolled on matched therapeutic trials, where available. Outcomes for all subsequent treatment events were recorded to data cut-off on January 31, 2022.ResultsA total of 215 patients were enrolled with successful NGS in 158 patients. The PI3K/AKT/PTEN pathway was the most altered with one or more of the pathway member genes PIK3/AKT/PTEN affected in 62% (98/158) patients and 43% of tumours harbouring a PIK3CA alteration. Tumour mutational burden (TMB) was reported in 96/109 FM1 sequenced patients, with a mean TMB of 5.04 mt/Mb and 13% (12/96) with TMB ≥ 10 mt/Mb. Treatment outcomes were evaluable in 105/158 patients, with a pooled total of 216 treatment events recorded. Matched treatment was administered in 47/216 (22%) events and associated with prolonged median progression-free survival (PFS) of 21.0 weeks [95% confidence interval (CI) 11.7, 26.0 weeks] versus 12.1 weeks (95% CI 10.0, 15.4 weeks) in unmatched, with hazard ratio (HR) for progression or death of 0.63 (95% CI 0.41, 0.97; p = 0.034). In the subgroup of PIK3/AKT/PTEN-altered MBC, the HR for progression or death was 0.57 (95% CI 0.35, 0.92; p = 0.02), favouring matched treatment. Per-patient overall survival (OS) analysis (n = 105) showed improved survival for patients receiving matched treatment versus unmatched, with median OS (mOS) of 30.1 versus 11.8 months, HR = 0.45 (95% CI 0.24, 0.84; p = 0.013). Objective response rate (ORR) in the overall population was similar in matched and unmatched treatment events (23.7% versus 17.2%, odds ratio of response 1.14 95% CI 0.50, 2.62; p = 0.75).ConclusionsBroad-panel NGS in MBC is feasible, allowing therapeutic matching, which was associated with improvements in PFS and OS.
Associations of single and multiple vitamin exposure with childhood eczema: data from the national health and nutrition examination survey
Authors: Wang Fang , Wang Xiaolie , Wang Jiayan , Liu Biqing 
Published: May 2024

AimThe association between vitamins and eczema has garnered attention, yet few studies have evaluated the effects of co-exposure to multiple vitamins on this condition. This study aims to assess the association of vitamin mixtures with eczema in children.MethodsThis cross-sectional study analyzed data from 2,244 children aged 6–17 years from the National Health and Nutrition Examination Surveys. Eczema served as the primary outcome. Six serum vitamins, namely, vitamins A, B6, B12, C, D, and E, were the main variables. Weighted multivariate logistic regression was adopted to analyze the association between each serum vitamin and eczema. Odds ratios (OR) with a 95% confidence interval (CI) were calculated. Bayesian kernel machine regression (BKMR) analysis and the quantile g-computation (qgcomp) model were used to evaluate the association of co-exposure to multiple vitamins with eczema.ResultsIn total, 10.83% of children (n = 243) developed eczema. After adjusting for confounding factors, we observed that compared with the reference group (vitamin B12 with second quartile), the OR for eczema was 0.604 (95% CI: 0.373–0.978, P = 0.041) for the first quartile of vitamin B12. Both BKMR analysis and the qgcomp model consistently showed that co-exposure to the six vitamins was positively correlated with the risk of eczema, with vitamin B6 contributing most to the overall effect. In BKMR analyses, we observed an interaction between vitamins B6 and B12 concerning eczema risk.ConclusionCo-exposure to vitamins A, C, B6, B12, D, and E was found to be associated with an increased risk of eczema in children, with vitamin B6 as the greatest positive contributor driving the overall effect.
Feature engineering of environmental covariates improves plant genomic-enabled prediction
Authors: Montesinos-López Osval A. , Crespo-Herrera Leonardo , Pierre Carolina Saint , Cano-Paez Bernabe , Huerta-Prado Gloria Isabel , Mosqueda-González Brandon Alejandro , Ramos-Pulido Sofia , Gerard Guillermo , Alnowibet Khalid , Fritsche-Neto Roberto , Montesinos-López Abelardo , Crossa José 
Published: May 2024

IntroductionBecause Genomic selection (GS) is a predictive methodology, it needs to guarantee high-prediction accuracies for practical implementations. However, since many factors affect the prediction performance of this methodology, its practical implementation still needs to be improved in many breeding programs. For this reason, many strategies have been explored to improve the prediction performance of this methodology.MethodsWhen environmental covariates are incorporated as inputs in the genomic prediction models, this information only sometimes helps increase prediction performance. For this reason, this investigation explores the use of feature engineering on the environmental covariates to enhance the prediction performance of genomic prediction models.Results and discussionWe found that across data sets, feature engineering helps reduce prediction error regarding only the inclusion of the environmental covariates without feature engineering by 761.625% across predictors. These results are very promising regarding the potential of feature engineering to enhance prediction accuracy. However, since a significant gain in prediction accuracy was observed in only some data sets, further research is required to guarantee a robust feature engineering strategy to incorporate the environmental covariates.
Mental health literacy, mental health experiences and help-seeking behaviours of Chinese elite athletes: a qualitative study
Authors: Bu Danran , Zhang Chun-Qing , Liu Jing-Dong , Han Zhe , Wang Xiang , Huang Zhijian 
Published: May 2024

IntroductionElite athletes' help-seeking on mental health might be influenced by their mental health literacy (MHL) and mental health experiences. The current study aimed to explore the MHL, experiences and help-seeking behaviours among elite athletes using a qualitative approach.MethodsFace-to-face semi-structured interviews were conducted among 20 Chinese elite athletes, 12 coaches, and 5 team officials. Interview data was analyzed using content analysis.ResultsSeven main themes emerged from the analysis. The current study revealed that Chinese elite athletes suffered from various mental health issues and athletes' MHL levels, help-seeking attitudes and intentions, Chinese sports environments, and Chinese cultural background could impact their help-seeking behaviours.ConclusionSupport for Chinese elite athletes' mental health and help-seeking requires improvement.
A potential pathway for identifying hypertension among urban residents aged 60+ years in China: the role of health insurance
Authors: Dou Yu , Guo Hongmei , Liu Sijun , Xu Huiqing , Li Fengli , Tao Wanying , Jia Shifen , Tian Siyu , Deng Tianrui , Xiong Yaqing , Xu Fei 
Published: May 2024

BackgroundIdentification is the first step for treatment of hypertension. However, the awareness rate of hypertension was not high globally. This study aimed to examine the potential role of health insurance for early-identifying hypertension among urban older residents in China.MethodsIn this cross-sectional study, urban residents aged 60+ years were chosen from Nanjing municipality of China in 2018. The outcome measure was hypertension status (“no hypertension,” “diagnosed hypertension” or “un-diagnosed hypertension”). Independent variable was health insurance (“Urban Employee Basic Medical Insurance scheme, UEBMI” or “Urban Resident Basic Medical Insurance scheme, URBMI”). Logistic regression models were introduced to estimate odds ratio (OR) and 95% confidence interval (CI) to examine the association between health insurance and hypertension.ResultsTotally, 19,742 participants completed the study. Among overall, URBMI and UEBMI participants, 47.2% (95%CI = 46.5, 47.9%), 38.4% (95%CI = 37.3, 39.6%) and 52.1% (95%CI = 51.2, 53.0%), separately, were diagnosed with hypertension, while the prevalence of un-diagnosed hypertension was 12.7% (95%CI = 12.2, 13.2%), 18.5% (95%CI = 17.6, 19.4%) and 9.6% (95%CI = 9.1, 10.1%), respectively. For overall participants, those with UEBMI were more likely to have hypertension identified (OR = 1.20; 95%CI = 1.11, 1.29) and at lower odds to experience un-diagnosed hypertension (OR = 0.68; 95%CI = 0.61, 0.76) compared to their counterparts with URBMI after control for potential confounders. Moreover, such associations of health insurance with diagnosed and un-diagnosed hypertension were also observed among participants stratified by age and gender.ConclusionFavorable health insurance may be a pathway for identifying hypertension among urban older residents in China. This study has important public health implications that hypertension may be identified early through favorable health insurance policies for older residents in China.
An ethnography of construction and characteristics of curriculum for inheritance of intangible cultural heritage martial arts in universities
Authors: Cheng Yuanlong , Guo Nana 
Published: May 2024

BackgroundInheriting excellent traditional Chinese culture is a prerequisite for ensuring the continuity of the cultural genes of the Chinese nation. However, with the historical mission of shaping the national character of the descendants of the Chinese nation, intangible cultural heritage martial arts face the problem of an unclear curriculum content construction mechanism in university inheritance and make it difficult for these martial arts to shoulder the responsibility of cultural inheritance in the era.MethodEducational ethnography as a research method is conducive to the in-depth exploration of the mechanism of curriculum content construction in the inheritance of intangible cultural heritage martial arts in universities.ResultsResearch suggests that the construction of curriculum content for the inheritance of intangible cultural heritage martial arts in universities relies on the form of cooperation between universities and inheritors, and form three models of curriculum content construction: off campus, on campus, and on-campus cooperation. The construction of curriculum content for off-campus inheritors belongs to the “attachment style” model, which is based on the actual needs of the inheritors and the selection of boxing types. The construction of curriculum content for inheritors on campus belongs to the “reshaping” model, which is the inheritor's “simplification and reorganization” based on traditional routines and subjective and objective conditions of inheritance. The construction of course content in school local cooperation belongs to the “integrated” model, which is the reintegration of course content by universities based on their own development characteristics and the characteristics of various martial arts.ConclusionIn the inheritance of intangible cultural heritage martial arts in universities, emphasis is placed on local knowledge, core skills, cultural traditions, and other characteristics, highlighting the excellence of its cultural inheritance. In the future, the focus of the inheritance of these martial arts in universities should be to cultivate innovative talents who are familiar with both traditional and modern martial arts.
Comparative Genomics Unveils Functional Diversity, Pangenome Openness, and Underlying Biological Drivers among Bacillus subtilis Group
Authors: Wang Taiquan , Shi Yiling , Zheng Mengzhuo , Zheng Jinshui 
Published: May 2024

The Bacillus subtilis group (Bs group), with Bacillus subtilis as its core species, holds significant research and economic value in various fields, including science, industrial production, food, and pharmaceuticals. However, most studies have been confined to comparative genomics analyses and exploration within individual genomes at the level of species, with few conducted within groups across different species. This study focused on Bacillus subtilis, the model of Gram-positive bacteria, and 14 other species with significant research value, employing comparative pangenomics as well as population enrichment analysis to ascertain the functional enrichment and diversity. Through the quantification of pangenome openness, this work revealed the underlying biological drivers and significant correlation between pangenome openness and various factors, including the distribution of toxin–antitoxin- and integrase-related genes, as well as the number of endonucleases, recombinases, repair system-related genes, prophages, integrases, and transfer mobile elements. Furthermore, the functional enrichment results indicated the potential for secondary metabolite, probiotic, and antibiotic exploration in Bacillus licheniformis, Bacillus paralicheniformis, and Bacillus spizizenii, respectively. In general, this work systematically exposed the quantification of pangenome openness, biological drivers, the pivotal role of genomic instability factors, and mobile elements, providing targeted exploration guidance for the Bs group.
The Role of Sustainable Design in Interior Spaces for Kindergartens
Authors: Hameed Salih Halla , Saadi Lafta Raja 
Published: May 2024

سعت الحكومات والمؤسسات الدولية على حث مواطنيها تبني مبدأ الاستدامة في تصميم العمارة والفضاءات الداخلية، اذ يعد التصميم الداخلي واستخدام مفاهيم جديدة مغايرة من اهم القضايا التي تشغل بال المصممين والمطورين في مجال التصميم الداخلي, وخصوصا ًمع بروز تحديات جديدة من خلال التطور العملي والتقني الهائل الذي القى بظلاله على المحتوى والفضاء التصميمي ، اذ تستخلص الباحثة مشكلة البحث بالتساؤل الذي يتمركز حول دراسة مدى استيعاب المصممين الداخليين لفكرة المغايرة وإظهار دورها المستدام في تصميم الفضاءات الداخلية لرياض الأطفال الذي يحقق الوظيفية لتحقيق الاستدامة ، كما ان أهمية البحث في توفير بيئة سليمة للأطفال في رياض الأطفال والتي تعد من اهم العوامل التي لا بد ان يهتم بها المصمم الداخلي على وفق المغايرة المستدامة ، وقد تضمن الفصل الثاني على الاطار النظري على مبحثين احتوى الأول على مفهوم المغايرة وآلية اشتغالها في التصميم الداخلي ، اما المبحث الثاني فتناول مفهوم الإستدامة ودورها في تصميم الفضاءات الداخلية ، وتضمن الفصل الثالث منهجية البحث واجراءاته ، اذ استند البحث على المنهج الوصفي في تحليل نموذج البحث ، اما الفصل الرابع تضمن نتائج البحث واهمها :ان نظم الإضاءة الطبيعية والصناعية المستخدمة في الفضاءات (التعليمية والخدمية ) في فضاء الرياض محققة للجوانب الوظيفية والجمالية ، اما الاستنتاجات فهي التصميم للبيئة المستدامة , وهو اتجاه تصميمي عالمي يركز على أهمية العلاقة بين الانسان والبيئة الداخلية والمغايرة التصميمية المستدامة .
Possible improving the reliability of water supply in the Republic of Crimea through the potential of high-water periods
Authors: Николенко И.В. , Каримов Э.А. , Мельникова Н.С. 
Published: May 2024

На основе анализа наполнения водохранилищ естественного стока Крымского полуострова в многоводный период выполнена оценка возможных способов решения проблем дефицита водных ресурсов в Крыму. В связи с аварией на гидроузле Каховского водохранилища подача воды из Днепра самотеком в настоящее время невозможна, поэтому для вододефицитных периодов региона необходим поиск дополнительных методов обеспечения водной безопасности и устойчивости систем водоснабжения. Анализ наполнения водохранилищ естественного стока Крымского полуострова за многолетний период показал, что их приток существенно различается для засушливых и многоводных лет. Установлена целесообразность более полного использования водотоков во время весенних и летних паводков многоводных периодов путем увеличения суммарного полезного объема водохранилищ естественного стока Крыма. Выполнена оценка применимости и адекватности разработанной модели по определению величины максимальных суточных объемов наполнения водохранилищ естественного стока Крымского полуострова при отсутствии технологического сброса из них. Проведен анализ полученных результатов, а также даны рекомендации по их реализации.
Based on an analysis of the storage of natural flow water reservoirs of the Crimean Peninsula during high-water periods, an estimation of possible ways to solve the problems of water resource shortages in Crimea was carried out. Due to the failure at the Kakhovka Reservoir hydroengineering facility, supplying water from the Dnieper by gravity is at the moment impossible; therefore, for the periods of water scarcity in the region developing additional methods of providing for water security and sustainability of water supply systems is required. The analysis of the storage of natural flow water reservoirs of the Crimean Peninsula over a long-term period showed that their inflow differed significantly between dry and high-water years. The feasibility of more efficient use of the watercourses during spring and summer floods of high-water periods was established by increasing the total available storage of the natural flow reservoirs of the Crimea. The applicability and adequacy of the developed model for determining the maximum daily volume of filling the natural flow reservoirs of the Crimean Peninsula in the absence of process drains from them were estimated. An analysis of the results obtained was carried out, and recommendations for their implementation were given.
Identification of microorganisms, dominants in treatment systems removing ethylene glycol from wastewater
Authors: Зубов М.Г. , Кадревич А.А. , Полякова А.В. , Вильсон Е.В. 
Published: May 2024

Представлены результаты исследований по автоселекции биоценоза, окисляющего этиленгликоль. Показано, что формирование деструктирующего этиленгликоль биоценоза без использования специальных штаммов происходит на 12-е сутки, выход на стационарный режим составляет от 40 до 64 суток в зависимости от требуемой концентрации этиленгликоля в очищенной воде. В результате проведенных микробиологических исследований были определены основные деструктирующие этиленгликоль культуры биоценоза: Staphylococcus capitis, Staphylococcus saprophyticus, Pseudomonas putida и Pseudomonas aureofaciens. При этом доминирующими являются культуры рода Pseudomonas.
The results of studies on autoselection of biocenosis that oxidizes ethylene glycol are presented. It has been shown that the formation of an ethylene glycol-destructive biocenosis eliminating the use of special strains occurs on the 12th day, reaching process stabilization from 40 to 64 days, depending on the required concentration of ethylene glycol in the effluent. As a result of the microbiological studies, the main ethylene glycol-destructive cultures of the biocenosis were identified: Staphylococcus capitis, Staphylococcus saprophyticus, Pseudomonas putida and Pseudomonas aureofaciens. Herewith, the dominant cultures are the genus Pseudomonas.