bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effectiveness, safety, and tolerability of delayed dexamethasone, rituximab, and cyclophosphamide as first-line treatment in patients with Waldenström macroglobulinemia: data from the Sicilian Myeloma Network
Authors: Del Fabro Vittorio , Markovic Uros , Frazzetto Sara , Sciortino Roberta , Bellofiore Claudia , Di Giorgio Mary Ann , Leotta Valerio , Bulla Anna , Pelle Angelo Curto , Elia Federica , Mannina Donato , Consoli Ugo , Mineo Giuseppe , Giallongo Cesarina , Romano Alessandra , Di Raimondo Francesco , Conticello Concetta 
Published: June 2024

BackgroundWaldenström macroglobulinemia (WM) is a rare and indolent B-cell lymphoproliferative disorder with greater incidence in elderly patients where a precise algorithm of initial therapy is still not clear. Immunochemotherapy regimen consisting of dexamethasone, rituximab, and oral cyclophosphamide (DRC) is considered a suitable first-line treatment because of its safety, efficacy, and manageability.Patients and methodsWe retrospectively describe the results of 36 consecutive treatment-naïve patients with WM who were treated from June 2013 until June 2021 with the DRC regimen every 4 weeks instead of 3 weeks, for six cycles. The median age was 69 years (range, 42–85 years), with one-third being older than 75 years. Most patients had features of advanced disease, with nearly 60% being high risk. Median IgM level prior to treatment initiation was 2.9 g/dL.ResultsOverall response rate was 80% after a median time of two cycles, with 67% of patients achieving at least partial response. After a median follow-up of 59 months, the median overall survival (OS) was not reached and the median time to next treatment (TTNT) was 48 months (95% CI 25–87 months). Approximately 70% of the evaluable study population had a 3-year survival without additional treatment, while 75% had a 3-year OS rate. The treatment was well-tolerated with only two patients (6%) recorded to have grade 3 pneumonia and no grade 3 hematological toxicity maybe due to the regular use of growth factors for red and white blood cells. Baseline albumin level and achievement of at least minimal or partial response had a significant impact on TTNT, while baseline hemoglobin and IgA level affected outcome in terms of OS (p &lt; 0.05).ConclusionThis is the first real-life experience describing the use of the DRC regimen in treatment-naive patients with WM with administration of therapy every 4 weeks instead of 3 weeks showing apparent comparable efficacy, along with good tolerability and safety, especially in terms of hematological toxicity, independently from comorbidity burden.
The mediating effect of job involvement in the relationship between tennis Instructors' perceived organizational justice and turnover intentions: a multi-group analysis across generations
Authors: Kim Sujin , Kim Jongho 
Published: June 2024

IntroductionThis study aimed to analyze the role of job involvement as a mediator in the relationship between tennis coaches' perceived organizational justice and their intention to leave, considering the unique professional context and demands of tennis coaching. Additionally, it sought to identify any generational differences in this model. The research categorizes perceived organizational justice into procedural and distributive justice, and job involvement into job attachment and job commitment.MethodsThe study incorporated data from 201 coaches working at commercial tennis facilities nationwide. Perceived organizational justice and job involvement were measured using validated scales. The mediation model was tested using structural equation modeling (SEM), and a multi-group analysis was conducted to identify generational differences.ResultsResults indicated that job involvement partially mediated the relationship between perceived organizational justice and turnover intentions, with distributive justice having a stronger total effect. The multi-group analysis revealed generational variances: distributive justice influenced turnover intentions more among the MZ generation, while procedural justice had a greater impact on the older generation.DiscussionThese findings offer valuable insights for commercial tennis facilities aiming to reduce turnover and manage generational conflicts. Understanding the differential impacts of procedural and distributive justice on various generations can help tailor strategies to enhance organizational operation and employee retention.ConclusionThe study highlights the importance of perceived organizational justice and job involvement in influencing tennis coaches' turnover intentions. The generational differences observed suggest that targeted interventions based on generational characteristics can be effective in reducing turnover and improving organizational stability. Future research should explore other potential mediators and extend the model to different sports and organizational contexts.
Food waste behaviors of the families of the Cilento Bio-District in comparison with the national data: elements for policy actions
Authors: Di Veroli Jacopo Niccolò , Peronti Benedetta , Scognamiglio Umberto , Baiamonte Irene , Paoletti Flavio , Stefanovic Lilliana , Bügel Susanne Gjedsted , Aboussaleh Youssef , Średnicka-Tober Dominika , Rossi Laura 
Published: June 2024

IntroductionConsumer food waste at the household level results from a complex set of behaviors depending on the local food environment, among other factors. This study mainly aimed at comparing food waste behaviors in the Cilento Bio-District with those recorded at the national level to explore if the organic district model had an impact on food waste attitude as a sustainability element.MethodsHousehold food waste behavior indicators performed better at the national level than in the Cilento Bio-District, with some relevant exceptions, such as the avoidance of having too much food at home and impulse buying.ResultsThe study results suggest that some food waste attitudes in the rural community of the Bio-District might be so embedded in everyday practices that they are no longer perceived as relevant descriptors, considering the lower food waste (FW) levels in Cilento compared to national data. The key findings of the study were interpreted for policy action development.DiscussionThe overall priority of actions would be the enhancement of consumers’ abilities to impact practices for food waste prevention. Community engagement aspects and the local products’ promotion should be particularly pursued in the Cilento Bio-District, while broader policy actions were proposed at the national level with the involvement of the different sectors of the food chain and the proposition of regulatory aspects (e.g., labels). Future research on Cilento Bio-District characteristics and the comparison with national data would need a more comprehensive examination of additional factors affecting the food system, such as dietary patterns or organic product consumption, to understand their potential influence on food waste and, in general, the sustainability of food choices.
Food safety in informal public markets in Kenya: perceptions of stakeholders in the food chain
Authors: Kuboka Maureen , Grace Delia , Artursson Karin , Lindahl Johanna , Carlsson Gunnar , Mutua Florence 
Published: June 2024

IntroductionInformal markets play a crucial role in providing fresh and nutritious foods for people in low and middle-income countries. However, the safety of food sold in these markets remains a major concern, contributing to a high burden of foodborne illnesses.MethodsThis study was designed to analyze stakeholder perceptions of food safety in selected informal public markets in Kenya. Eight focus group discussions and 15 key informant interviews were conducted. In addition, two workshops were held to validate the findings.Results and discussionWe found that consumers and vendors confounded food quality, especially freshness, with safety, and paid more attention to appearance and physical qualities than food safety. Information (such as branding and expiry dates) and heuristic cues (such as the flow of buyers and the presence of flies) were used to assess food safety. Meat was perceived as the food most likely to cause disease. Chemical hazards in fresh produce and aflatoxins in maize were mentioned as priority hazards by both vendors and consumers. Stakeholders more knowledgeable about food safety considered microbial hazards as a top priority. Although diarrheal diseases were reported to be prevalent in the communities, these were often thought to be the result of agri-chemical residues in fresh produce or the consumption of high-fat foods, and not commonly linked to bacteria in food. Gaps identified during the interviews included poor infrastructure, inadequate food safety knowledge, insufficient or prohibitive policies, insufficient political will, and poor food safety-related practices. There were few mentions of lack of motivation or incentives for behavior change, or insufficient consumer demand for food safety. To fill the gaps, several opportunities were discussed, including contextualizing policies and regulations, investing in infrastructure, capacity building, and training, and promoting involvement and collaboration among various stakeholders.ConclusionThis study has highlighted gaps and misperceptions that need to be addressed through proper knowledge and awareness to effectively combat foodborne disease challenges. Behavioral change approaches to improve food safety are recommended.
Associations of overweight/obesity with patient-reported outcome measures after oblique lumbar interbody fusion
Authors: Hsueh Lan-Li , Wu Yun-Che , Pan Chien-Chou , Shih Cheng-Min , Lee Cheng-Hung , Wang Jun-Sing , Chen Kun-Hui 
Published: June 2024

BackgroundOblique lateral interbody fusion (OLIF) combined with transpedicular screw fixation has been practiced for degenerative spinal diseases of elderly patients for years. However, overweight patients have been shown to have longer operative times and more complications from surgery. The effect on clinical outcome is still uncertified. The objective of this study was to determine is overweight a risk factor to clinical outcome of OLIF combined with transpedicular screw fixation technique.Material and methodsA retrospective study in patients submitted to OLIF combined with transpedicular screw fixation from January 2018 to August 2019 was conducted. VAS score, ODI score and EQ5D were measured before the operation and one year after the operation.ResultsA total of 111 patients were included with 48 patients in the non-obese group and 55 patients in the overweight/obese group. There was no significant difference between the two groups in gender, age, smoking history, hypertension, chronic kidney disease and diabetes mellitus. Overweight/obese group has higher BMI (28.4 vs. 22.7, p &lt; 0.001) than non-obese group. There was no difference between the two groups in pre-operative VAS score, ODI score and EQ5D score. However, the healthy weight group improved much more than the overweight score in VAS score, ODI score and EQ5D score.ConclusionThe overweight/obese patient group had clinical outcomes worse than the non-obese group in terms of pain relief and life functions.
Assessment of pharmacologically induced changes in canine kidney function by multiparametric magnetic resonance imaging and contrast enhanced ultrasound
Authors: Hillaert Amber , Sanmiguel Serpa Luis Carlos , Bogaert Stephanie , Broeckx Bart J. G. , Hesta Myriam , Vandermeulen Eva , Germonpré Jolien , Stock Emmelie , Pullens Pim , Vanderperren Katrien 
Published: June 2024

IntroductionDynamic contrast-enhanced (DCE) MRI and arterial spin labeling (ASL) MRI enable non-invasive measurement of renal blood flow (RBF), whereas blood oxygenation level-dependent (BOLD) MRI enables non-invasive measurement of the apparent relaxation rate (R2*), an indicator of oxygenation. This study was conducted to evaluate the potential role of these MRI modalities in assessing RBF and oxygenation in dogs. The correlation between contrast-enhanced ultrasound (CEUS) and the MRI modalities was examined and also the ability of the MRI modalities to detect pharmacologically induced changes.MethodsRBF, using CEUS, ASL- and DCE-MRI, as well as renal oxygenation, using BOLD-MRI of eight adult beagles were assessed at two time-points, 2–3 weeks apart. During each time point, the anesthetized dogs received either a control (0.9% sodium chloride) or a dopamine treatment. For each time point, measurements were carried out over 2 days. An MRI scan at 3 T was performed on day one, followed by CEUS on day two.ResultsUsing the model-free model with caudal placement of the arterial input function (AIF) region of interest (ROI) in the aorta, the DCE results showed a significant correlation with ASL measured RBF and detected significant changes in blood flow during dopamine infusion. Additionally, R2* negatively correlated with ASL measured RBF at the cortex and medulla, as well as with medullary wash-in rate (WiR) and peak intensity (PI). ASL measured RBF, in its turn, showed a positive correlation with cortical WiR, PI, area under the curve (AUC) and fall time (FT), and with medullary WiR and PI, but a negative correlation with medullary rise time (RT). During dopamine infusion, BOLD-MRI observed a significant decrease in R2* at the medulla and entire kidney, while ASL-MRI demonstrated a significant increase in RBF at the cortex, medulla and the entire kidney.ConclusionASL- and BOLD-MRI can measure pharmacologically induced changes in renal blood flow and renal oxygenation in dogs and might allow detection of changes that cannot be observed with CEUS. However, further research is needed to confirm the potential of ASL- and BOLD-MRI in dogs and to clarify which analysis method is most suitable for DCE-MRI in dogs.
Outcomes of Robotic Transabdominal Retromuscular Repair: 3-Year Follow-up
Authors: Garza Aquiles , Amaya-Romero Cesar , Arevalo Gabriel 
Published: June 2024

BackgroundOur study addresses the gap in ventral hernia repair literature, regarding the long-term effectiveness of robotic transabdominal retrorectus umbilical prosthetic repair (r-TARUP) for primary and incisional ventral hernias. This study aimed to report the 3-year recurrence rates and overall patient outcomes including quality of life.MethodA retrospective review of prospective collected data analyzed 101 elective r-TARUP patients from August 2018 to January 2022. Data collected included demographics, hernia sizes, mesh types, postoperative outcomes and the European Hernia Society Quality of Life questionnaire (EuraHS-QoL) before and after surgery.ResultsThe average age of the group of patients was 53, having a mean body mass index (BMI) of 32 kg/m, with 54% incisional and 46% primary hernias, with mean length and width of 4.4 cm and 6.1 cm, utilizing synthetic 58% and bioabsorbable 42% mesh types. The majority were classified as Centers of Disease Control and Prevention (CDC) class I wounds. Postoperative complications included seroma (2%), hematoma (3%), which required surgical intervention, with no significant correlation to mesh type. A strong positive correlation was found between Transversus Abdominis Release (TAR) and increased length of hospital stay (correlation coefficient: 0.731, p<0.001). Preoperative quality of life assessments demonstrated statistically significant improvements when compared to postoperative assessments at 3 years, with a mean (±SD) of 61.61 ± 5.29 vs. 13.84 ± 2.6 (p<0.001). Mean follow up of 34.4 months with no hernia recurrence at 1 year and 3 recurrence at the 2-3 years follow up (3.2%).ConclusionThe r-TARUP technique has proven to be safe and effective for repairing primary and incisional ventral hernias, with a low recurrence rate during this follow up period with a noticeable improvement in quality of life (QoL).
أخلاقيات إدارة المحتوى على فيسبوك وتويتر: دراسة تحليلية للسياسات والشروط.
Authors: عيساني رحيمة 
Published: June 2024

هدفت هذه الدّراسة إلى تّعرف ماهية الأخلاقيات المهنية التي تدار بها الحسابات في كل من فيسبوك وتويتر، ودراسة وتحليل سياسات وشروط إدارة الحساب على الشّبكتين، وعناصرها، والقواعد الأخلاقية التي بُنيت عليها، والتي تلزم مستخدميها بالتّقيد بها ابتداء، والموافقة عليها قبل فتح وتفعيل الحساب. ولأجل استجلاء ودراسة هذه الأخلاقيات والشّروط طرحت الدّراسة تساؤلين رئيسيين:
1.	ما الأخلاقيات التي تلتزم بها كل من فيسبوك وتويتر في شروطهما وسياساتهما لإدارة الحساب؟
2.	وهل هي واضحة بالنّسبة للمستخدم من خلال صياغاتها وبنودها؟
واعتمدت منهج/ أداة تحليل المحتوى (الكمي) للعناصر الأساسية في صفحات الشّروط والسّياسات، وفق عدد من مفردات ووحدات التّحليل المعتمدة في المنهج. وتوصلت الدّراسة إلى مجموعة نتائج أهمها: أنّ شروط وسياسات كل من فيسبوك وتوتير على الرغم من أنها تحدّثت عن سياسة الخصوصية وشروط الخدمة،
- لتوفر للمستخدم معلومات كافية عن كيفية إنشاء المحتوى وإدارته.
- كانت واضحة وصريحة في بعض العبارات والشّروط والالتزامات.
فإنها:
•	بطرق غير أخلاقية تحرمه من "حق المعرفة".
•	لا تحمي خصوصيات المستخدم ولا تحترمها.
•	تنتهك وبشكل صارخ حقوق الملكية الفكرية وتتعدى عليها.
•	تنتهك حق المستخدم في التّحكم في محتويات حسابه التي وضعها بنفسه، وتتعدى على هذا الحق بمشاركتها مع شركائها من الشّركات والمؤسسات التّجارية بعلمه ودون علمه.
•	تنتهك حقه في المغادرة والإنهاء والحذف للحساب والبيانات، وتصرّح أنّها تلغي التّنشيط فقط.
NOVEL INTEGRATIVE MULTI-OMICS STRATEGIES OF HUMAN’S BIOLOGICAL AGE COMPUTATION
Authors: Соловьёв И.А. 
Published: June 2024

В работе дан обзор существующих исследований, использующих мультиомиксные интегративные подходы при подсчете биологического возраста человека. Проведен анализ наиболее распространенных вариантов интеграции метиломного, транскриптомного, протеомного, микробиомного и метаболомного блоков данных. Выделены: 1) конкатенация (машинное обучение), при которой разрабатываются модели с использованием объединенной матрицы данных, формируемые путем слияния нескольких наборов омиксных данных; 2) подходы на основе объединенных моделей, в рамках которых создается несколько промежуточных подмоделей для различных омиксных данных, чтобы затем построить окончательную интегральную модель; 3) методы преобразования (искусственным интеллектом), которые сначала трансформируют каждый из наборов единичных омиксных данных в сводные графики или матрицы, а затем объединяют их все в один график перед построением интегральной комплексной модели. Мультиомиксные подходы едва ли найдут применение в антивозрастной персонализированной медицине, но, вероятно, углубят и расширят понимание биологических часов старения.
Multi-omics methods for analysing postgenomic data have become firmly established in the tools of molecular gerontology only in recent years, since previously there were no comprehensive integrative approaches adequate to the task of calculating biological age. This paper provides an overview of existing papers on multi-omics integrative approaches in calculating the biological age of a human. An analysis of the most common options for integrating methylomic, transcriptomic, proteomic, microbiomic and metabolomic datasets was carried out. We defined (1) concatenation (machine learning), in which models are developed using a concatenated data matrix, formed by combining multiple omics data sets; (2) fusion model approaches that create multiple intermediate submodels for different omics data to then build a final integrated model from the various intermediate submodels; and (3) transformation methods (via artificial intelligence) that first transform each of the single omics data sets into core plots or matrices, and then combine them all into one graph before building an integral complex model. It is unlikely that multi-omics approaches will find application in anti-aging personalized medicine, but they will undoubtedly deepen and expand the understanding of the fundamental processes standing behind the phenomenon of the biological aging clocks.
ECONOMIC INDEX — PREDICTOR OF PREMATURE AGING
Authors: Сагинбаев У.Р. , Ахмедов Т.А. , Рукавишников А.С. 
Published: June 2024

Широко известно, что в экономически развитых странах наблюдается увеличение доли лиц старшего возраста. Однако проблема влияния территориальных особенностей экономического развития на темпы старения населения недостаточно освещена. Цель работы — изучение влияния показателей экономического развития (ПЭР) на процессы преждевременного старения населения. В качестве материалов взяты статистические сборники Минздрава России и Росстата за 2011– 2019 гг. Наиболее высокая инцидентность была характерна для катаракты и глаукомы. Установлена прямая корреляционная связь ПЭР и возрастного индекса заболеваемости (ВИЗ) катарактой (r=0,31; p=0,00436). Для группы регионов с высоким уровнем экономического развития было характерно более высокое значение ВИЗ, что, как правило, соответствует более позднему развитию заболевания.
It is widely known that in economically developed countries there is an increase in the proportion of older people. However, the problem of the influence of territorial features of economic development on the rate of population aging is not sufficiently covered. The goal was to study the impact of economic development indicators (EDI) on the processes of premature aging of the population. The materials were statistical collections of the Ministry of Health of Russia and Russian Statistics Service for 2011–2019. The highest incidence was characteristic of cataracts and glaucoma. A direct correlation has been established between the EDI and the age-specific incidence index (ASII) of cataracts (r=0,31; p=0,00436). A group of regions with a high level of economic development was characterized by a higher value of ASII, which, as a rule, corresponds to the later development of the disease.
Pemakaian Skincare pada Perempuan Masa Iddah dalam Perspektif Kitab Tausyikh Karya Syekh Nawawi
Authors: Rahmawati Isma , Ulum Bahrul 
Published: June 2024

Eksistensi Skincare pada masa sekarang sangat marak dipakai oleh para perempuan, pemakaian Skincare seperti sudah menjadi kebutuhan primer seorang perempuan. Sebenarnya tidak ada larangan dalam memakai Skincare, asalkan barang yang dipakai telah bersertifikasi BPOM dan berverifikasi halal agar tetap aman ketika dipakai. Akan tetapi jika dikaitkan dengan iddah, apakah perempuan masih diperbolehkan memakai Skincare ketikah sedang masa iddah?, maka masih perlu mengkaji hukumnya dalam sudut pandang Madzhab Syafi’i khususya dalam Kitab Tausyikh karangan Muhammad Nawawi bin Umar Al-Jawi. Tujuan penelitian ini untuk mengetahui bagaimana hukum pemakaian Skincare pada seorang perempuan masa iddah, Karena masih minim sekali pemahaman perempuan mengenai ini. Dalam penelitian ini, metode yang digunkan yakni library research dengan mengumpulkan kata atau kalimat individu yang hal tersebut dinilai relevan dalam membahas mengenai iddah seorang perempuan khususnya dalam Madzhab Imam Syafi’i. Sumber data primer adalah kitab-kitab Syafi’iyah, sedangkan data sekunder berupa buku dan jurnal. Dari penelitian ini ditemukan hasil bahwa jumhur ulama’ Syafi’iyah tidak memperbolehkan pemakaian Skincare pada perempuan yang sedang iddah wafat dan memperbolehkan pada perempuan yang sedang iddah cerai karena hal ini berhubungan dengan ihdad, yang diwajibkan berihdad yakni perempuan yang sedang iddah wafat bukan iddah cerai. Karena hikmah dari berihdad tidak lain untuk bentuk bela sungkawa karena suaminya meninggal.
Kata kunci: skincare; perempuan; iddah; Tausyikh; hukum perceraian