bluuebunny/crossref_metadata_2025_split huggingface dataset:
Diagnosis of Borrelia‐associated uveitis in two horses
Authors: Priest Heather L. , Irby Nita L. , Schlafer Donald H. , Divers Thomas J. , Wagner Bettina , Glaser Amy L. , Chang Yung‐Fu , Smith Mary C. 
Published: February 2012

AbstractBorrelia burgdorferi, the etiologic agent of Lyme disease is a tick born spirochetal infection. Clinical signs of Lyme borreliosis are uncommon in horses, but when present they are often vague and nonspecific. In horses, Lyme borreliosis has been implicated in musculoskeletal, neurological, reproductive, and ocular disorders, including uveitis, but definitive diagnosis can be challenging as the causative agent is rarely isolated and serologic tests can be unreliable and do not confirm active disease. Here, we report two cases of equine uveitis associated with B. burgdorferi based on the identification of spirochetes within ocular fluids and confirmed with PCR testing. The two cases illustrate some of the challenges encountered in the recognition and diagnosis of equine Lyme borreliosis. Although only one of many possible causes of equine uveitis, Lyme disease should be considered a differential diagnosis, especially in endemic areas. Given the possibility for false negative results of serum tests during uveitis associated with B. burgdorferi and the failure of such tests to confirm active infection, a combination of cytologic assessment, antibody, and/or PCR testing of ocular fluids may be worthwhile if the clinical suspicion for Lyme uveitis is high.
STRUCTURAL CHANGE IN A SMALL OPEN ECONOMY: AN APPLICATION TO SOUTH KOREA
Authors: MaO RUI , YAO YANG 
Published: February 2012

AbstractThis paper develops a dynamic general equilibrium model and studies structural change in a small open economy with two tradable sectors, agriculture and manufacturing, and a non‐tradable sector, services. In addition to obtaining results for a falling employment share of agriculture and a rising share of services, we demonstrate analytically the hump‐shaped share of manufacturing by identifying two countervailing effects: the productivity effect and the Balassa–Samuelson effect. The first effect, arising from differential rates of productivity growth among sectors, increases the share of manufacturing; the second effect, together with low rates of substitution between products, enhances the service sector and eventually draws labour from the manufacturing sector. At the aggregate level, however, the economy maintains a constant rate of growth. We calibrate the model with data from South Korea and find that the calibration fits the country's historical path of structural change.
Neurofibromatosis 1 phenotype associated to malignant peripheral nerve sheath tumours: a case‐control study
Authors: Zehou O. , Bularca S. , Bastuji‐Garin S. , Ortonne N. , Valeyrie‐Allanore L. , Wolkenstein P. , Duong T.A. 
Published: February 2012

AbstractBackground  Malignant peripheral nerve sheath tumours (MPNSTs) are the main cause of death in neurofibromatosis 1 adult patients.Objectives  To determine the clinical type of neurofibromas associated to MPNSTs.Methods  Case‐control study. Cases were neurofibromatosis 1 adults with MPNSTs and controls were patients without MPNSTs individually matched by age and sex (1 : 3). Both were recruited from our database. The following variables were studied: clinical presence of cutaneous, subcutaneous or plexiform neurofibromas and of internal neurofibromas. Internal neurofibromas were confirmed by clinical imaging. Multivariate odds ratios (aORs) were estimated with their 95% confidence interval (CI).Results  From January 1995 to December 2007, 52 patients (cases) were identified with a MPNSTs, 155 controls could be recruited. In the multivariate analysis, MPNSTs were significantly associated with the presence of internal NFs (aOR: 7.5; 95% CI: 3.2–17.4), a trend for an association was observed for the presence of subcutaneous neurofibromas (aOR: 2.11; 95% CI: 0.89–5).Conclusions  This study confirms the association between the MPNSTs and the internal neurofibromas. The later are indeed associated with a high risk of malignant transformation.
Influence of socio‐demographical, behavioural and attitudinal factors on the amount of avoidable food waste generated in Finnish households
Authors: Koivupuro Heta‐Kaisa , Hartikainen Hanna , Silvennoinen Kirsi , Katajajuuri Juha‐Matti , Heikintalo Noora , Reinikainen Anu , Jalkanen Lotta 
Published: February 2012

AbstractThis paper presents the results of a questionnaire and food waste diary study on the influence of socio‐demographical, behavioural and attitudinal factors on the amount of avoidable household food waste in 380 Finnish households. The research data were collected through a 2‐week food waste diary study accompanied by a background questionnaire. The influences of socio‐demographical, behavioural and attitudinal factors on the production of food waste were studied through application of descriptive statistics. It was established that only few factors clearly correlate with the amount of avoidable food waste. The factors that influenced the amount of food wasted were the size of the household, the gender of the person mainly responsible of grocery shopping, the frequency of buying discounted food products, the respondent's own view of the potential to reduce food waste and the respondent's own view of the influence of purchasing particular food packet sizes. The main factors with which no clear correlation was detected included age of the oldest person in household; area, form and type of residence; educational level and type of work of adults in the family; and shopping, food preparation and eating habits.
Accessing and affording sustainability: the experience of fashion consumption within young families
Authors: Ritch Elaine L. , Schröder Monika J. 
Published: February 2012

AbstractDespite the ever increasing levels of fashion consumption, neither retailers nor consumers have as yet implemented sustainability principles to a significant degree. This is despite the fact that sustainability principles are increasingly understood and will be applied by consumers, as long as affordable alternatives in mainstream fashions are available. In a highly competitive fashion retail sector, there exists an opportunity for UK high street fashion retailers to differentiate their brand image through aligning products with consumers' moral frameworks. Using phenomenological interviews, this research explores the fashion consumption experiences of professional women with young children and living in or near Edinburgh, with particular focus on their expression of their own sustainability concerns in their day‐to‐day practices. The findings reveal that in the absence of suitable products, information and labelling, consumers apply heuristics to their choices, especially price. They refer to the more familiar ethical food market which serves as a metaphor for fashion‐related practices. They talk about trustworthy retailers and about how they deal with and rationalize their own practices where they reveal an obvious attitude‐behaviour gap. The women's role of providing for the family adds further complexity in a sector which provides affordable alternative options.
Do environmental attitudes and food technology neophobia affect perceptions of the benefits of nanotechnology?
Authors: Matin Anahita Hosseini , Goddard Ellen , Vandermoere Frédéric , Blanchemanche Sandrine , Bieberstein Andrea , Marette Stephan , Roosen Jutta 
Published: February 2012

AbstractIn recent years, a significant amount of research has focussed on the analysis of consumers' aversion to new technologies in food production and processing. At the same time, research has shown that environmental attitudes may be related to purchasing behaviour of consumers. This paper presents the result of an investigation into Canadian attitudes towards nanotechnology, in general, and in applications in the food industry. The relationship between the food technology neophobia scale, environmental attitudes and nanotechnology is examined. The results suggest that food technology neophobia is significant in explaining attitudes towards nanotechnology, in general, and for food packaging and foods. Environmental attitudes are important in explaining respondents' attitudes towards nanotechnology in general but not in explaining attitudes towards nanotechnology in food packaging or food applications. Survey respondents' views of the role of science and technology in society (makes society worse or better off) are a more important determinant of attitudes towards nanotechnology than whether they had heard of nanotechnology prior to the survey.
Peripheral Extracorporeal Membrane Oxygenation System as Salvage Treatment of Patients With Refractory Cardiogenic Shock: Preliminary Outcome Evaluation
Authors: Loforte Antonio , Montalto Andrea , Ranocchi Federico , Della Monica Paola Lilla , Casali Giovanni , Lappa Angela , Menichetti Antonio , Contento Carlo , Musumeci Francesco 
Published: February 2012

AbstractThe novel Permanent Life Support (PLS; Maquet, Jostra Medizintechnik AG, Hirrlingen, Germany) as peripheral veno‐arterial extracorporeal membrane oxygenation (ECMO) support system has been investigated as treatment for patients with refractory cardiogenic shock (CS). Between January 2007 and July 2011, 73 consecutive adult patients were supported on peripheral PLS ECMO system at our institution (55 men; age 60.3 ± 11.6 years, range: 23–84 years). Indications for support were failure to wean from cardiopulmonary bypass in the setting of postcardiotomy (n = 50) and primary donor graft failure (n = 8), post‐acute myocardial infarction CS (n = 12), and CS on chronic heart failure (n = 3). Mean support time was 10.9 ± 7.6 days (range: 2–34 days). Overall, 26 (35.6%) patients died on ECMO. Among survivors on ECMO, 44 (60.2%) patients were successfully weaned from support, and three (4.1%) were switched to a mid–long‐term ventricular assist device. Thirty‐three (45.2%) were successfully discharged. The following variables were significantly different if survivors and nonsurvivors on ECMO were compared: age (P = 0.04), female gender (P < 0.01), cardiopulmonary resuscitation before ECMO (P < 0.01), lactate level before ECMO (P = 0.01), number of platelets, fresh frozen plasma units, and packed red blood cells (PRBCs) transfused during ECMO support (P = 0.03, P = 0.02, and P < 0.01), blood lactate level (P = 0.01), and creatine kinase isoenzyme MB (CK‐MB) relative index 72 h after ECMO initiation (P < 0.001), and multiple organ failure on ECMO (P < 0.01). Stepwise logistic regression identified blood lactate level and CK‐MB relative index at 72 h after ECMO initiation, and number of PRBCs transfused on ECMO as significant predictors of mortality on ECMO (P = 0.011, odds ratio [OR] = 2.48; 95% confidence interval [CI] = 1.11–3.12; P = 0.012, OR = 2.81, 95% CI = 1.026–2.531; and P = 0.012, OR = 1.94, 95% CI = 1.02–5.21; respectively). Patients with an initial poor hemodynamic status could benefit by rapid peripheral installation of PLS ECMO. The blood lactate level, CK‐MB relative index, and PRBCs transfused should be strictly monitored during ECMO support.
Prevalence and Burden of Headaches as Assessed by the Health Family Program
Authors: Silva Junior Ariovaldo A. , Bigal Marcelo , Vasconcelos Luiz P. B. , Rodrigues Joismar , Gomez Rodrigo S. , Krymchantowski Abouch V. , Moreira Filho Pedro , Teixeira Antonio L. 
Published: February 2012

Background.— Unified health systems often have Family Health Programs (FHPs) as a core component of their preventive and early curative strategies. In Brazil, the FHP is established to proactively identify diseases such as diabetes and hypertension.Objective.— To use the FHP in order to assess the prevalence of primary headaches, as per the Second Edition of the International Classification of Headache Disorders in a Brazilian city covered by the program, and to document the burden of migraine and tension‐type headache (TTH) in this population.Methods.— FHP agents were trained on how to apply questionnaires that screened for the occurrence of headaches in the past year. Screening method had been previously validated. Respondents that screened positively were interviewed by a headache specialist, and all their headache types were classified. Additionally, disability (Migraine Disability Assessment Scale and Headache Impact Test) and health‐related quality of life were assessed.Results.— The 1‐year prevalence of migraine was 18.2% [95% confidence interval = 13.7; 23.5]. TTH occurred in 22.9% [18.0%; 28.6%]. Other primary headaches occurred in 10.8% of the participants. Idiopathic stabbing headache was significantly more common in individuals with migraine relative to those without migraine (44.7% vs 10.3%, P < .001). Contrasting with TTH, migraineurs had a mean of 3.1 headache types vs 1.9 in TTH (P < .001). Secondary headaches occurred in 21.7% of the participants over a 1‐year period [16.9%; 27.3%]. Most cases were headaches attributed to infection (mostly respiratory). The impact of migraine was bimodal. Most sufferers had little impact, but a sizable minority was severely impaired.Conclusions.— The FHP can be effectively used to bring individuals with headache to the attention of providers. Future investigations should assess whether this increased attention translates into improved outcomes.[Correction added after online publication 21‐Feb‐2012: The original publication contained an incorrect abstract. The above content replaces the abstract found in the originally published article.](Headache 2012;52:483‐490)
Twelve‐Month Tolerability and Efficacy Study of NP101, the Sumatriptan Iontophoretic Transdermal System
Authors: Smith Timothy R. , Goldstein Jerome , Singer Richard , Pugach Neil , Silberstein Stephen , Pierce Mark W. 
Published: February 2012

Objective.— To assess the long‐term tolerability and efficacy of NP101, a novel transdermal sumatriptan patch being developed for the acute treatment of migraine.Background.— Nausea (with or without vomiting) and gastroparesis have been characterized as being among the most problematic challenges affecting migraine care today. Migraine‐associated nausea can cause patients to delay or avoid taking oral medication with a resultant loss or reduction of therapeutic efficacy. Migraine‐associated gastroparesis can impair absorption and reduce bioavailability of oral migraine medications and thereby reduce and delay therapeutic efficacy. The non‐oral triptan formulations that have been used to overcome these challenges are associated with other shortcomings that can limit their use. Designed to overcome these shortcomings and treatment limitations imposed by gastrointestinal signs and symptoms, the NP101 patch avoids the need for oral administration, does not depend upon gastrointestinal absorption, and provides more consistent, predictable plasma concentrations than oral and intranasal formulations of sumatriptan and a lower maximum plasma concentration than sumatriptan injection.Methods.— Patients diagnosed with migraine who had participated in a randomized, double‐blind, Phase III study of the NP101 patch were given the option to use NP101 to treat migraine episodes with moderate or severe headache pain for up to 12 months in this open‐label trial.Results.— One hundred eighty‐three patients applied 2089 study patches. The most common adverse events involved the patch application site (45% of patients). The only non‐application‐site adverse events reported in >2% of patients were nausea (n = 6, 3.3%), upper respiratory tract infection (n = 6, 3.3%), and nasopharyngitis (n = 4, 2.2%). The incidence of triptan‐associated adverse events was 1.6%. Across all visits for investigator assessments, the majority of patients (ranging from 74.7% at Month 1 to 92.2% at Month 9) were scored as having no erythema at patch application sites. For patient assessments, the percentage of patch placement sites scored as having no or minimal redness was 38.2% at the time of patch removal and 65.4% 24 hours after patch activation. Two hours after patch activation across all patch treatments over the 12‐month study, 23.8% of initial acute migraine episodes were scored as being free from headache pain, 58.2% as having headache pain relief,78.9% as nausea free, 60.1% as phonophobia free, 53.4% as photophobia free, and 20.7% as migraine free. No evidence of waning tolerability or efficacy was observed over the 12‐month study period.Conclusion.— NP101, a transdermal sumatriptan formulation in development for the acute treatment of migraine, demonstrated tolerability and efficacy with successive uses over 12 months in this clinical trial.
Impaired object identification in idiopathic childhood occipital epilepsy
Authors: Brancati Claudia , Barba Carmen , Metitieri Tiziana , Melani Federico , Pellacani Simona , Viggiano Maria Pia , Guerrini Renzo 
Published: February 2012

SummaryPurpose:: To investigate whether children with epilepsy primarily affecting the occipital cortex exhibit impairment of visual object identification and to what extent such a hypothesized dysfunction is related to an interfering functional, rather than structural, process.Method:: We studied nine children with idiopathic childhood occipital epilepsy (ICOE) and compared them to eight children with lesional posterior cortex epilepsy (PCEs) and to 60 age‐matched controls. We applied an “ascendent” paradigm of object identification, using a coarse‐to‐fine order procedure, which gradually integrated spatial frequency information from the most blurred image to the complete figure. In children with ICOE, we explored how epilepsy‐related variables might be related to object identification task.Key Findings:: Children with ICOE and those with PCEs needed more physical information than controls to identify visual stimuli. There was a decreasing accuracy from controls to children with ICOE and from children with ICOE to those with PCEs. Children with ICOE demonstrated slight selective impairment in visuospatial processing and those among them having experienced a higher number of seizures or in whom interictal electroencephalography (EEG) discharges had been present for a longer time, required a higher level of physical information to recognize objects.Significance:: The observation that children with ICOE performed worse than controls in object identification, although better than children with PCEs, might indicate that functional disruption caused by epileptiform EEG abnormalities and seizures, can interfere per se with perceptual processes, even in the absence of a lesion. This effect appears to be detected only by perceptual and cognitive screening.
Kennedy Classification and Treatment Options: A Study of Partially Edentulous Patients Being Treated in a Specialized Prosthetic Clinic
Authors: Charyeva Olga O. , Altynbekov Kubeysin D. , Nysanova Bakhyt Z. 
Published: February 2012

AbstractPurpose: This study was done under the auspices of the Swedish International Development Cooperation Agency, whose aim is to improve living conditions in developing countries, including dental aid. Each year the number of medical staff from the European Union willing to help in developing countries increases, and it is thus important to highlight issues of development. From the Middle Asian region, the Republic of Kazakhstan was chosen. At present, few studies have evaluated the prevalence of various types of partial edentulism in this region, and no research has investigated the prosthetic treatment choice in the various types of partial edentulism. The purpose of this study was to determine (i) the prevalence of various types of partial edentulism in patients seeking dental care and (ii) the type of prosthetic restoration most commonly chosen to treat these patients.Materials and Methods: One hundred twelve patient records, together with panoramic radiographs, were studied. Various types of partial edentulism were grouped into four Kennedy classes. Patient records were used to examine which treatment option was chosen for each patient.Results: The most prevalent type of partial edentulism in this patient sample was Kennedy type III, in both the maxilla (50.0%) and the mandible (41.1%). Partial edentulism was most frequently managed by fixed partial dentures (FPDs) in both jaws. Kennedy IV was the least prevalent (7.1% in the maxilla, 5.6% in the mandible) and in most cases treated with removable partial dentures (RPDs) in both jaws.Conclusion: Our results are consistent with previous research on the prevalence of Kennedy classes in Kazakhstan. RPDs were the most common type of prosthetic management for partial edentulism.
Condylar Guidance: Correlation between Protrusive Interocclusal Record and Panoramic Radiographic Image: A Pilot Study
Authors: Tannamala Pavan Kumar , Pulagam Mahesh , Pottem Srinivas R. , Swapna B 
Published: February 2012

AbstractPurpose: The purpose of this study was to compare the sagittal condylar angles set in the Hanau articulator by use of a method of obtaining an intraoral protrusive record to those angles found using a panoramic radiographic image.Materials and Methods: Ten patients, free of signs and symptoms of temporomandibular disorder and with intact dentition were selected. The dental stone casts of the subjects were mounted on a Hanau articulator with a springbow and poly(vinyl siloxane) interocclusal records. For all patients, the protrusive records were obtained when the mandible moved forward by approximately 6 mm. All procedures for recording, mounting, and setting were done in the same session. The condylar guidance angles obtained were tabulated. A panoramic radiographic image of each patient was made with the Frankfurt horizontal plane parallel to the floor of the mouth. Tracings of the radiographic images were made. The horizontal reference line was marked by joining the orbitale and porion. The most superior and most inferior points of the curvatures were identified. These two lines were connected by a straight line representing the mean curvature line. Angles made by the intersection of the mean curvature line and the horizontal reference line were measured. The results were subjected to statistical analysis with a significance level of p < 0.05.Results: The radiographic values were on average 4° greater than the values obtained by protrusive interocclusal record method. The mean condylar guidance angle between the right and left side by both the methods was not statistically significant. The comparison of mean condylar guidance angles between the right side of the protrusive record method and the right side of the panoramic radiographic method and the left side of the protrusive record method and the left side of the panoramic radiographic method ( p= 0.071 and p= 0.057, respectively) were not statistically significant.Conclusion: Within the limitations of this study, it was concluded that the protrusive condylar guidance angles obtained by panoramic radiograph may be used in programming semi‐adjustable articulators.
Biological Adaptation to Misfits of Immediately Loaded Fixed Prostheses Following Computer‐Guided Surgery
Authors: Puterman Israel , Kan Joseph Y. K. , Rungcharassaeng Kitichai , Oyama Kotaro , Morimoto Taichiro , Lozada Jaime 
Published: February 2012

AbstractIn this clinical report, following computer‐guided (3D Procera Software Planning Program, Nobel Biocare, Yorba Linda, CA) placement and immediate provisionalization of 12 dental implants (NobelSpeedy™ Replace, Nobel Biocare), misfits of the prefabricated screw‐retained interim prostheses were noted at several implant‐abutment junctions. Nevertheless, adaptation of the misfits was observed 10 days later, after the loosened screws were tightened. While a high mean marginal bone loss of 2.1 mm (range: 1.4 to 3.5 mm) was noted, all implants remained osseointegrated at 3‐year follow‐up.