bluuebunny/crossref_metadata_2025_split huggingface dataset:
Visualization of Time‐Series Data in Parameter Space for Understanding Facial Dynamics
Authors: Tam G. K. L. , Fang H. , Aubrey A. J. , Grant P. W. , Rosin P. L. , Marshall D. , Chen M. 
Published: June 2011

AbstractOver the past decade, computer scientists and psychologists have made great efforts to collect and analyze facial dynamics data that exhibit different expressions and emotions. Such data is commonly captured as videos and are transformed into feature‐based time‐series prior to any analysis. However, the analytical tasks, such as expression classification, have been hindered by the lack of understanding of the complex data space and the associated algorithm space. Conventional graph‐based time‐series visualization is also found inadequate to support such tasks. In this work, we adopt a visual analytics approach by visualizing the correlation between the algorithm space and our goal – classifying facial dynamics. We transform multiple feature‐based time‐series for each expression in measurement space to a multi‐dimensional representation in parameter space. This enables us to utilize parallel coordinates visualization to gain an understanding of the algorithm space, providing a fast and cost‐effective means to support the design of analytical algorithms.
Prostate Cancer Visualization from MR Imagery and MR Spectroscopy
Authors: Marino Joseph , Kaufman Arie 
Published: June 2011

AbstractProstate cancer is one of the most prevalent cancers among males, and the use of magnetic resonance imaging (MRI) has been suggested for its detection. A framework is presented for scoring and visualizing various MR data in an efficient and intuitive manner. A classification method is introduced where a cumulative score volume is created which takes into account each of three acquisition types. This score volume is integrated into a volume rendering framework which allows the user to view the prostate gland, the multi‐modal score values, and the surrounding anatomy. A visibility persistence mode is introduced to automatically avoid full occlusion of a selected score and indicate overlaps. The use of GPU‐accelerated multi‐modal single‐pass ray casting provides an interactive experience. User driven importance rendering allows the user to gain insight into the data and can assist in localization of the disease and treatment planning. We evaluate our results against pathology and radiologists'determinations.
Antitumor Actions of Ruthenium(III)-Based Nitric Oxide Scavengers and Nitric Oxide Synthase Inhibitors
Authors: Flitney Frederick W. , Pritchard Rebecca J. , Kennovin Gordon D. , Bisland Stuart K. , Hirst David G. , Fricker Simon P. 
Published: June 2011

AbstractThe role of endogenous nitric oxide (NO) in the growth and vascularization of a rat carcinosarcoma (P22) has been investigated. Tumor-bearing animals were treated with (i) nitric oxide synthase (NOS) inhibitors, administered via the drinking water, including NG-nitro-l-arginine methyl ester (L-NAME), a nonisoform-selective inhibitor, and 2 others that target the inducible (NOS II) enzyme preferentially, namely 1-amino-2-hydroxyguanidine or N-[3-(aminomethyl)benzyl]acetamidine hydrochloride; or (ii) daily injections (intraperitoneally) of 2 Ru(III) polyaminocarboxylates, AMD6221 and AMD6245, both of which are effective NO scavengers. L-NAME, AMD6221, and AMD6245 reduced tumor growth by approximately 60% to 75% of control rates. Tumor sections stained with abs to CD-31/platelet endothelial cell adhesion molecule-1 or NOS III showed that this was associated with a marked reduction (60%–77%) of tumor microvascular densitiy (MVD). Tumors resumed growing promptly when treatment was discontinued, accompanied by partial or complete restoration of MVDs. In contrast, NOS-II selective inhibitors had no effect on tumor growth or vascularization, indicating that both responses require complete blockade of NO production. The results corroborate the view that endogenous NO facilitates tumor development. We suggest that NO deprivation causes tumor feeder vessels to constrict, reducing tumor blood flow. The delivery of oxygen and essential nutrients to the developing tumor is impaired as a consequence, hampering further growth. Normalizing NO levels by withholding treatment causes tumor feeder vessels to dilate, increasing tumor perfusion and reestablishing conditions that allow tumors to begin growing again. Mol Cancer Ther; 10(9); 1571–80. ©2011 AACR.
Symptomatic and incidental thromboembolism are both associated with mortality in pancreatic cancer
Authors: Menapace Laurel A. , Peterson Derick R. , Berry Andrea , Sousou Tarek , Khorana Alok A. 
Published: June 2011

SummaryPancreatic cancer is known to be associated with VTE, but contemporary rates of incidental and symptomatic VTE events and their association with mortality are incompletely understood. We conducted a retrospective cohort study of consecutive pancreatic adenocarcinoma patients at the University of Rochester from 2006–2009. Data were analysed using a Cox model with time-dependent covariates. A total of 1,151 radiologic exams of 135 patients were included. Forty-seven patients (34.8%) experienced VTE including 12 pulmonary emboli (PE), 28 deep-vein thromboses (DVTs) and 47 visceral vein events. Incidental events comprised 33.3% of PEs, 21.4% of DVTs and 100% of visceral VTE. Median (95% CI) conditional survival beyond three months was 233 (162–322) more days for those without VTE, which was significantly greater than 12 (3–60) days for those with DVT as first event (p<0.0001) and 87 (14–322) days with visceral first events (p=0.022). In multivariate analysis, DVT (HR 25, 95% CI 10–63, p <0.0001), PE (HR 8.9, 95% CI 2.5–31.7, p = 0.007) and incidental visceral events (HR 2.6, 95% CI 1.6–4.2, p =0.0001) were all associated with mortality, though anticoagulants reduced these risks by 70% (26–88%, p = 0.009). In conclusion, VTE occurs in over one-third of contemporary pancreatic cancer patients and, whether symptomatic or incidental, is strongly associated with worsened mortality. The role of anticoagulation in treating incidental or visceral VTE warrants further study.Note: The abstract of this manuscript was presented at the Annual Meeting of the American Society of Hematology, Orlando, FL, USA on December 5, 2010.
A comparison of the original and simplified Pulmonary Embolism Severity Index
Authors: Venetz Carmen , Jiménez David , Méan Marie , Aujesky Drahomir 
Published: June 2011

SummaryThe Pulmonary Embolism Severity Index (PESI) is a validated clinical prognostic model for patients with pulmonary embolism (PE). Recently, a simplified version of the PESI was developed. We sought to compare the prognostic performance of the original and simplified PESI. Using data from 15,531 patients with PE, we compared the proportions of patients classified as low versus higher risk between the original and simplified PESI and estimated 30-day mortality within each risk group. To assess the models’ accuracy to predict mortality, we calculated sensitivity, specificity, and predictive values and likelihood ratios for low-versus higher-risk patients. We also compared the models’ discriminative power by calculating the area under the receiver-operating characteristic curve. The overall 30-day mortality was 9.3%. The original PESI classified a significantly greater proportion of patients as low-risk than the simplified PESI (40.9% vs. 36.8%; p<0.001). Low-risk patients based on the original and simplified PESI had a mortality of 2.3% and 2.7%, respectively. The original and simplified PESI had similar sensitivities (90% vs. 89%), negative predictive values (98% vs. 97%), and negative likelihood ratios (0.23 vs. 0.28) for predicting mortality. The original PESI had a significantly greater discriminatory power than the simplified PESI (area under the ROC curve 0.78 [95% CI: 0.77–0.79] vs. 0.72 [95% CI: 0.71–0.74]; p<0.001). In conclusion, even though the simplified PESI accurately identified patients at low-risk of adverse outcomes, the original PESI classified a higher proportion of patients as low-risk and had a greater discriminatory power than the simplified PESI.Institution where the work was carried out: Division of General Internal Medicine, Bern University Hospital, Bern, Switzerland.
Closing the Global Water Vapor Budget with AIRS Water Vapor, MERRA Reanalysis, TRMM and GPCP Precipitation, and GSSTF Surface Evaporation
Authors: Wong Sun , Fetzer Eric J. , Kahn Brian H. , Tian Baijun , Lambrigtsen Bjorn H. , Ye Hengchun 
Published: June 2011

Abstract
The authors investigate if atmospheric water vapor from remote sensing retrievals obtained from the Atmospheric Infrared Sounder/Advanced Microwave Sounding Unit (AIRS) and the water vapor budget from the NASA Goddard Space Flight Center (GSFC) Modern Era Retrospective-analysis for Research and Applications (MERRA) are physically consistent with independently synthesized precipitation data from the Tropical Rainfall Measuring Mission (TRMM) or the Global Precipitation Climatology Project (GPCP) and evaporation data from the Goddard Satellite-based Surface Turbulent Fluxes (GSSTF). The atmospheric total water vapor sink (Σ) is estimated from AIRS water vapor retrievals with MERRA winds (AIRS–MERRA Σ) as well as directly from the MERRA water vapor budget (MERRA–MERRA Σ). The global geographical distributions as well as the regional wavelet amplitude spectra of Σ are then compared with those of TRMM or GPCP precipitation minus GSSTF surface evaporation (TRMM–GSSTF and GPCP–GSSTF P − E, respectively). The AIRS–MERRA and MERRA–MERRA Σs reproduce the main large-scale patterns of global P − E, including the locations and variations of the ITCZ, summertime monsoons, and midlatitude storm tracks in both hemispheres. The spectra of regional temporal variations in Σ are generally consistent with those of observed P − E, including the annual and semiannual cycles, and intraseasonal variations. Both AIRS–MERRA and MERRA–MERRA Σs have smaller amplitudes for the intraseasonal variations over the tropical oceans. The MERRA P − E has spectra similar to that of MERRA–MERRA Σ in most of the regions except in tropical Africa. The averaged TRMM–GSSTF and GPCP–GSSTF P − E over the ocean are more negative compared to the AIRS–MERRA, MERRA–MERRA Σs, and MERRA P − E.
In-vitro and in-vivo phenotype of type Asia 1 foot-and-mouth disease viruses utilizing two non-RGD receptor recognition sites
Authors: Li Pinghua , Lu Zengjun , Bao Huifang , Li Dong , King Donald P , Sun Pu , Bai Xingwen , Cao Weijun , Gubbins Simon , Chen Yingli , Xie Baoxia , Guo Jianhong , Yin Hong , Liu Zaixin 
Published: June 2011

Abstract

Background
Foot-and-mouth disease virus (FMDV) uses a highly conserved Arg-Gly-Asp (RGD) triplet for attachment to host cells and this motif is believed to be essential for virus viability. Previous sequence analyses of the 1D-encoding region of an FMDV field isolate (Asia1/JS/CHA/05) and its two derivatives indicated that two viruses, which contained an Arg-Asp-Asp (RDD) or an Arg-Ser-Asp (RSD) triplet instead of the RGD integrin recognition motif, were generated serendipitously upon short-term evolution of field isolate in different biological environments. To examine the influence of single amino acid substitutions in the receptor binding site of the RDD-containing FMD viral genome on virus viability and the ability of non-RGD FMDVs to cause disease in susceptible animals, we constructed an RDD-containing FMDV full-length cDNA clone and derived mutant molecules with RGD or RSD receptor recognition motifs. Following transfection of BSR cells with the full-length genome plasmids, the genetically engineered viruses were examined for their infectious potential in cell culture and susceptible animals.

Results
Amino acid sequence analysis of the 1D-coding region of different derivatives derived from the Asia1/JS/CHA/05 field isolate revealed that the RDD mutants became dominant or achieved population equilibrium with coexistence of the RGD and RSD subpopulations at an early phase of type Asia1 FMDV quasispecies evolution. Furthermore, the RDD and RSD sequences remained genetically stable for at least 20 passages. Using reverse genetics, the RDD-, RSD-, and RGD-containing FMD viruses were rescued from full-length cDNA clones, and single amino acid substitution in RDD-containing FMD viral genome did not affect virus viability. The genetically engineered viruses replicated stably in BHK-21 cells and had similar growth properties to the parental virus. The RDD parental virus and two non-RGD recombinant viruses were virulent to pigs and bovines that developed typical clinical disease and viremia.

Conclusions
FMDV quasispecies evolving in a different biological environment gained the capability of selecting different receptor recognition site. The RDD-containing FMD viral genome can accommodate substitutions in the receptor binding site without additional changes in the capsid. The viruses expressing non-RGD receptor binding sites can replicate stably in vitro and produce typical FMD clinical disease in susceptible animals.
Underuse of long-term routine hospital follow-up care in patients with a history of breast cancer?
Authors: Lu Wenli , Jansen Liesbeth , Schaapveld Michael , Baas Peter C , Wiggers Theo , De Bock Geertruida H 
Published: June 2011

Abstract

Background
After primary treatment for breast cancer, patients are recommended to use hospital follow-up care routinely. Long-term data on the utilization of this follow-up care are relatively rare.

Methods
Information regarding the utilization of routine hospital follow-up care was retrieved from hospital documents of 662 patients treated for breast cancer. Utilization of hospital follow-up care was defined as the use of follow-up care according to the guidelines in that period of time. Determinants of hospital follow up care were evaluated with multivariate analysis by generalized estimating equations (GEE).

Results
The median follow-up time was 9.0 (0.3-18.1) years. At fifth and tenth year after diagnosis, 16.1% and 33.5% of the patients had less follow-up visits than recommended in the national guideline, and 33.1% and 40.4% had less frequent mammography than recommended. Less frequent mammography was found in older patients (age > 70; OR: 2.10; 95%CI: 1.62-2.74), patients with comorbidity (OR: 1.26; 95%CI: 1.05-1.52) and patients using hormonal therapy (OR: 1.51; 95%CI: 1.01-2.25).

Conclusions
Most patients with a history of breast cancer use hospital follow-up care according to the guidelines. In older patients, patients with comorbidity and patients receiving hormonal therapy yearly mammography is performed much less than recommended.
More resistant tendons obtained from the association of Heteropterys aphrodisiaca and endurance training
Authors: Monteiro Juliana C , Gomes Marcos LM , Tomiosso Tatiana C , Nakagaki Wilson R , Sbervelheri Mariana M , Ferrucci Danilo L , Pimentel Edson R , Dolder Heidi 
Published: June 2011

Abstract

Background
Popular Brazilian medicine uses Heteropterys aphrodisiaca infusion as a tonic or stimulant, for the treatment of nervous debility and breakdown and for muscle and bone weakness. This study investigated the effects of Heteropterys aphrodisiaca infusion on the tendon properties and extracellular matrix of rats under endurance training.

Methods
Wistar rats were grouped as follows: CS- control sedentary, HS- H. aphrodisiaca sedentary, CT-control trained, HT- H. aphrodisiaca trained. The training protocol consisted in running on a motorized treadmill, five times a week, with weekly increase in treadmill speed and duration. Control groups received water while the HS and HT groups received H. aphrodisiaca infusion, daily, by gavage for the 8 weeks of training. Achilles tendons were frozen for biochemical and biomechanical analysis or preserved in Karnovsky's fixative, then processed for histomorphological analysis with light microscopy.

Results
Biomechanical analysis showed significant increase in maximum load, maximum stress, modulus of elasticity and stiffness of the HT animals' tendons. The metalloproteinase-2 activity was reduced in the HT group. The compression region of HT animals' tendons had a stronger and more intense metachromasy, which suggests an increase in glycosaminoglycan concentration in this region of the tendon. The most intense birefringence was observed in both compression and tension regions of HT animals' tendons, which may indicate a higher organizational level of collagen bundles. The hydroxyproline content increased in the HT group.

Conclusions
The association of endurance training with H. aphrodisiaca resulted in more organized collagen bundles and more resistant tendons to support higher loads from intense muscle contraction. Despite the clear anabolic effects of Heteropterys aphrodisiaca and the endurance exercise association, no side effects were observed, such as those found for synthetic anabolic androgenic steroids.
Operator preconditioning with efficient applications for nonlinear elliptic problems
Authors: Karátson Janos 
Published: June 2011

Abstract
This paper is devoted to the numerical solution of nonlinear elliptic partial differential equations. Such problems describe various phenomena in science. An approach that exploits Hilbert space theory in the numerical study of elliptic PDEs is the idea of preconditioning operators. In this survey paper we briefly summarize the main lines of this theory with various applications.
The Prevalence and Intensity of Louse (Phthiraptera, Mallophaga) and Tick (Acarina: Ixodidae) Infestation of Birds in South African Grasslands
Authors: Kopij G. , Price R. 
Published: June 2011

The Prevalence and Intensity of Louse (Phthiraptera, Mallophaga) and Tick (Acarina: Ixodidae) Infestation of Birds in South African Grasslands
A total of 270 birds represented by 12 species were examined for the presence of lice and ticks. Birds were collected in South African grasslands. Extensity of louse and tick infestation ranged from 10% to 80% and from 3% to 33% respectively. Average number of lice per host species ranged from 1 to 15, while average number of ticks per host species ranged from 1 to 5. Only single specimens (0.4%) were heavily parasited by lice and ticks respectively. Lice infested birds more often during the dry season, while ticks infested birds mainly during the rain season.
Mantis Religiosa (Dyctioptera, Mantidae) Infected by Wolbachia
Authors: Bilousov O. , Chaplinska M. , Zhuk O. , Gorobchyshyn V. , Kozeretska I. 
Published: June 2011

Mantis Religiosa(Dyctioptera, Mantidae) Infected byWolbachiaFor the first time, endosymbiotic bacteria of the genusWolbachiawere found to infect soothsayers,Mantis religiosa(Linnaeus, 1758). Mantises were collected at two locations in vicinity of Mykolaiv and Kaniv, Ukraine. Tested individuals were not infected by Cardinium and Spiroplasma.
A New Species of the Genus Rhaphium (Dolichopodidae, Diptera) from Siberia
Authors: Negrobov O. , Barkalov A. , Selivanova O. 
Published: June 2011

A New Species of the Genus Rhaphium (Dolichopodidae, Diptera) from Siberia
Rhaphium sibiricus Negrobov, Barkalov et Selivanova, sp. n. is described from the Altai Mountains. The new species is similar to Rhaphium gruniniani Negrobov, 1979, differing by black legs, simple, not thickened tip of fore basitarsus, length ratio of apical portion of vein CuA1 to crossvein dm-cu and by the shape of gonopodes.
The Milnor–Stasheff Filtration on Spaces and Generalized Cyclic Maps
Authors: Iwase Norio , Mimura Mamoru , Oda Nobuyuki , Yoon Yeon Soo 
Published: June 2011

AbstractThe concept of Ck-spaces is introduced, situated at an intermediate stage between H-spaces and T-spaces. The Ck-space corresponds to the k-th Milnor–Stasheff filtration on spaces. It is proved that a space X is a Ck-space if and only if the Gottlieb set G(Z, X) = [Z, X] for any space Z with cat Z ≤ k, which generalizes the fact that X is a T-space if and only if G(ΣB, X) = [ΣB, X] for any space B. Some results on the Ck-space are generalized to the -space for a map ƒ : A → X. Projective spaces, lens spaces and spaces with a few cells are studied as examples of Ck-spaces, and non-Ck-spaces.
On Constructing Ergodic Hyperfinite Equivalence Relations of Non-Product Type
Authors: Munteanu Radu-Bogdan 
Published: June 2011

AbstractProduct type equivalence relations are hyperfinitemeasured equivalence relations, which, up to orbit equivalence, are generated by product type odometer actions. We give a concrete example of a hyperfinite equivalence relation of non-product type, which is the tail equivalence on a Bratteli diagram. In order to show that the equivalence relation constructed is not of product type we will use a criterion called property A. This property, introduced by Krieger for non-singular transformations, is defined directly for hyperfinite equivalence relations in this paper.
New Examples of Non-Archimedean Banach Spaces and Applications
Authors: Perez-Garcia C. , Schikhof W. H. 
Published: June 2011

AbstractThe study carried out in this paper about some new examples of Banach spaces, consisting of certain valued fields extensions, is a typical non-archimedean feature. We determine whether these extensions are of countable type, have t-orthogonal bases, or are reflexive. As an application we construct, for a class of base fields, a norm ║ · ║ on c0, equivalent to the canonical supremum norm, without non-zero vectors that are ║ · ║-orthogonal and such that there is a multiplication on c0 making (c0, ║ · ║) into a valued field.
Creating a Human Brain Proteome Atlas – 13th HUPO BPP Workshop March 30–31, 2010, Ochang, Korea
Authors: Gröttrup Bernd , Stephan Christian , Marcus Katrin , Grinberg Lea T. , Wiltfang Jens , Lee Sang K. , Kim Young H. , Meyer Helmut E. , Park Young M. 
Published: June 2011

AbstractThe HUPO Brain Proteome Project (HUPO BPP) held its 13th workshop in Ochang from March 30th to 31st, 2010 prior to the Korean HUPO 10th Annual International Proteomics Conference. The principal aim of this project is to obtain a better understanding of neurodiseases and aging with the ultimate objective of discovering prognostic and diagnostic biomarkers, in addition to the development of novel diagnostic techniques and new medications. The attendees came together to discuss progress in the clinical neuroproteomics of human and to define the needs and guidelines required for more advanced proteomics approaches.
Prospective Randomized Trial of Laparoscopic Nissen Fundoplication With Anterior Versus Posterior Hiatal Repair: Late Outcomes
Authors: Chew Carolyn R. , Jamieson Glyn G. , Devitt Peter G. , Watson David I. 
Published: June 2011

AbstractBackgroundThe technique used for hiatal closure in laparoscopic Nissen fundoplication might have an impact on the risk of postfundoplication dysphagia and hiatal herniation. In 1997, we commenced a randomized trial to evaluate the impact of anterior versus posterior hiatal repair techniques on these outcomes. In the present study, we evaluated the 10‐year outcomes from this trial.MethodsA total of 102 patients were randomized to undergo laparoscopic Nissen fundoplication with either anterior (47 patients) or posterior (55 patients) repair of the diaphragmatic hiatus. Outcomes were assessed using standardized clinical assessment scores that evaluated reflux symptoms, dysphagia, and satisfaction with the outcome following surgery.ResultsClinical outcomes 10 years after surgery were available for 93% of patients, and outcome scores were obtained for 43 patients in each group. Patients undergoing anterior hiatal repair were less likely to report dysphagia for lumpy solid foods (14.0% vs. 39.5%, p = 0.01), although there were no significant differences in dysphagia outcomes for six other dysphagia assessment scores. There were no differences between the two groups for reflux symptoms, medication use, and overall satisfaction with the outcome of surgery.ConclusionsAt the 10‐year follow‐up, the outcomes for the two groups were similar. Anterior hiatal repair is an acceptable technique for hiatal closure during laparoscopic Nissen fundoplication.