bluuebunny/crossref_metadata_2025_split huggingface dataset:
Patterns of neurogenic lower urinary tract dysfunction management and associated factors among Chinese community-dwelling individuals with spinal cord injury
Authors: Zhang Mengyang , Chen Ye , Liu Jiawei , Luo Can , Chen Zhong , Xu Tao 
Published: June 2024

AbstractTo identify different patterns of neurogenic lower urinary tract dysfunction management among Chinese community-dwelling individuals with spinal cord injury and explore the factors associated with latent classes. This was a cross-sectional study conducted in communities throughout China Mainland. Participants were recruited through the China Association of Persons with Physical Disability and a total of 2582 participants was included in the analysis. The data were collected by a questionnaire consisting of socio-demographic factors, disease-related factors, and a list of 8 bladder management methods. Latent class analysis was used to identify different latent classes of neurogenic lower urinary tract dysfunction management. Then the multinomial logistic regression was applied to analyze the relationship between neurogenic lower urinary tract dysfunction management patterns and socio-demographic and disease-related factors. Neurogenic lower urinary tract dysfunction management pattern among community-dwelling individuals with spinal cord injury was divided into four latent classes: “urinal collecting apparatus dominated pattern” (40.3%), “bladder compression dominated pattern” (30.7%), “intermittent catheterization dominated pattern” (19.3%) and “urethral indwelling catheterization dominated pattern” (9.6%). Multinomial logistic regression analysis found that the employment status, residential region, nursing need, payment method for catheterization products, hand function, time since spinal cord injury, urinary incontinence and concerns about social interaction affected by urination problems were significantly associated with latent classes. Only 19.3% of people used the intermittent catheterization as their main neurogenic lower urinary tract dysfunction management method. More attention needs to be paid to the promotion of the standardization process of intermittent catheterization in community-dwelling individuals with spinal cord injury. The associated factors of the four classes can be used for tailored and targeted interventions to increase the use of intermittent catheterization.
Identification of influential parameters and conditions in heavy metals adsorption onto Cal-LDH-PC using optimization approaches of RSM and Taguchi
Authors: Mohrazi Ava , Ghasemi-Fasaei Reza , Mojiri Amin , Safarzadeh Sedigheh 
Published: June 2024

AbstractAdsorption process plays an important role in the remediation of heavy metals (HMs) from wastewater. A laboratory trial was conducted to investigate effective parameters for improving the bio-adsorption removal of HMs. SEM, EDX, BET, and FTIR techniques were applied to characterize the calcined layer double hydroxide (Cal-LDH), pectin (PC), and Cal-LDH-PC composite prepared from Licorice pomace. The adsorption of zinc (Zn) cadmium, nickel (Ni) and lead (Pb) onto the most efficient sorbent was investigated using RSM methodology with operational factors such as concentration, reaction time, sorbent dose, and pH. The results related to FTIR showed that Cal-LDH-PC had the highest number of functional groups. Based on the SEM results Cal-LDH had a low surface area (9.36 m2 g-1) and a small pore size (9.22 nm). After the modification process (Cal-LDH-PC), the values of surface area and pore size increased by 13-fold (120 m2 g-1) and 1.5-fold (18 nm), respectively. Cal-LDH had high adsorption performance, more cavities, stability, various functional groups, and excessive carbon and oxygen content, which make it efficient and powerful in removing HMs from wastewater. The optimal condition for achieving the removal efficiency (RE%) values of metals was determined to be 80.79 mg L−1, 100 min, 0.167 g L−1, and 9 for concentration, reaction time, sorbent dose, and pH, respectively. Maximum adsorption capacity and RE (%) were 300 mg g−1 and 99% for Zn. According to the results concentration had a major impact on RE% (except for Ni), while for Ni, adsorbent dose had the most significant impact. The present study introduced Cal-LDH-PC prepared from Licorice pomace as a capable, useful and economical sorbent for HMs removal from polluted environments. Taguchi's statistical method is distinguished as an economic method with easier interpretation, while the RSM approach is more accurate, and it can also check the interaction of parameters.
Integrated satellite observations unravel the relationship between urbanization and anthropogenic non-methane volatile organic compound emissions globally
Authors: Pu Dongchuan , Zhu Lei , Shen Huizhong , Smedt Isabelle De , Ye Jianhuai , Li Juan , Shu Lei , Wang Dakang , Li Xicheng , Zuo Xiaoxing , Yang Xin , Fu Tzung-May 
Published: June 2024

AbstractAs urban areas expand globally, human activities are leading to a sustained increase in non-methane volatile organic compound (NMVOC) emissions, escalating both environmental and health-related concerns. Given their diverse origins, estimating anthropogenic NMVOC emissions levels from global urban areas remains challenging. Here, we integrate TROPOspheric Monitoring Instrument (TROPOMI) formaldehyde (HCHO) column data, Visible Infrared Imaging Radiometer Suite (VIIRS) nighttime light (NTL) radiance data, and the Emission Database for Global Atmospheric Research (EDGAR) to develop a method for estimating global anthropogenic NMVOC emissions. Furthermore, we construct a linear model to analyze the relationship between urbanization and anthropogenic NMVOC emissions. Our research reveals that meticulously filtered TROPOMI HCHO columns have a high Pearson correlation coefficient (r = 0.91) with anthropogenic NMVOC emissions, indicating its reliability as an indicator reflecting the levels of anthropogenic NMVOC emissions. We establish linear models at various scales, including global, continental, and national, linking HCHO columns (as indicators of anthropogenic NMVOC emissions) and NTL radiance (as an indicator of urbanization). The global-scale linear model exhibits an r of 0.81, with a slope of 0.42 × 1015 molec. cm−2 nanoWatts−1 cm2 sr and an intercept of 9.26 × 1015 molec. cm−2. This linear model reflects a positive correlation between urbanization and anthropogenic NMVOC emissions, also serving as a tool for estimating the levels of anthropogenic NMVOC emissions in urban areas. This study offers valuable insights for real-time monitoring of extensive anthropogenic NMVOC emissions.
Computationally derived transition points across phases of clinical care
Authors: Gilson Aidan , Chartash David , Taylor R. Andrew , Hart Laura C. 
Published: June 2024

AbstractThe objective of this study is to use statistical techniques for the identification of transition points along the life course, aiming to identify fundamental changes in patient multimorbidity burden across phases of clinical care. This retrospective cohort analysis utilized 5.2 million patient encounters from 2013 to 2022, collected from a large academic institution and its affiliated hospitals. Structured information was systematically gathered for each encounter and three methodologies - clustering analysis, False Nearest Neighbor, and transitivity analysis - were employed to pinpoint transitions in patients’ clinical phase. Clustering analysis identified transition points at age 2, 17, 41, and 66, FNN at 4.27, 5.83, 5.85, 14.12, 20.62, 24.30, 25.10, 29.08, 33.12, 35.7, 38.69, 55.66, 70.03, and transitivity analysis at 7.27, 23.58, 29.04, 35.00, 61.29, 67.03, 77.11. Clustering analysis identified transition points that align with the current clinical gestalt of pediatric, adult, and geriatric phases of care. Notably, over half of the transition points identified by FNN and transitivity analysis were between ages 20 and 40, a population that is traditionally considered to be clinically homogeneous. Few transition points were identified between ages 3 and 17. Despite large social and developmental transition at those ages, the burden of multimorbidities may be consistent across the age range. Transition points derived through unsupervised machine learning approaches identify changes in the clinical phase that align with true differences in underlying multimorbidity burden. These transitions may be different from conventional pediatric and geriatric phases, which are often influenced by policy rather than clinical changes.
Telomeric RNA (TERRA) increases in response to spaceflight and high-altitude climbing
Authors: Al-Turki Taghreed M. , Maranon David G. , Nelson Christopher B. , Lewis Aidan M. , Luxton Jared J. , Taylor Lynn E. , Altina Noelia , Wu Fei , Du Huixun , Kim JangKeun , Damle Namita , Overbey Eliah , Meydan Cem , Grigorev Kirill , Winer Daniel A. , Furman David , Mason Christopher E. , Bailey Susan M. 
Published: June 2024

AbstractTelomeres are repetitive nucleoprotein complexes at chromosomal termini essential for maintaining genome stability. Telomeric RNA, or TERRA, is a previously presumed long noncoding RNA of heterogeneous lengths that contributes to end-capping structure and function, and facilitates telomeric recombination in tumors that maintain telomere length via the telomerase-independent Alternative Lengthening of Telomeres (ALT) pathway. Here, we investigated TERRA in the radiation-induced DNA damage response (DDR) across astronauts, high-altitude climbers, healthy donors, and cellular models. Similar to astronauts in the space radiation environment and climbers of Mt. Everest, in vitro radiation exposure prompted increased transcription of TERRA, while simulated microgravity did not. Data suggest a specific TERRA DDR to telomeric double-strand breaks (DSBs), and provide direct demonstration of hybridized TERRA at telomere-specific DSB sites, indicative of protective TERRA:telomeric DNA hybrid formation. Targeted telomeric DSBs also resulted in accumulation of TERRA foci in G2-phase, supportive of TERRA’s role in facilitating recombination-mediated telomere elongation. Results have important implications for scenarios involving persistent telomeric DNA damage, such as those associated with chronic oxidative stress (e.g., aging, systemic inflammation, environmental and occupational radiation exposures), which can trigger transient ALT in normal human cells, as well as for targeting TERRA as a therapeutic strategy against ALT-positive tumors.
Regional brain aging: premature aging of the domain general system predicts aphasia severity
Authors: Busby Natalie , Newman-Norlund Sarah , Sayers Sara , Rorden Chris , Newman-Norlund Roger , Wilmskoetter Janina , Roth Rebecca , Wilson Sarah , Schwen-Blackett Deena , Kristinsson Sigfus , Teghipco Alex , Fridriksson Julius , Bonilha Leonardo 
Published: June 2024

AbstractPremature brain aging is associated with poorer cognitive reserve and lower resilience to injury. When there are focal brain lesions, brain regions may age at different rates within the same individual. Therefore, we hypothesize that reduced gray matter volume within specific brain systems commonly associated with language recovery may be important for long-term aphasia severity. Here we show that individuals with stroke aphasia have a premature brain aging in intact regions of the lesioned hemisphere. In left domain-general regions, premature brain aging, gray matter volume, lesion volume and age were all significant predictors of aphasia severity. Increased brain age following a stroke is driven by the lesioned hemisphere. The relationship between brain age in left domain-general regions and aphasia severity suggests that degradation is possible to specific brain regions and isolated aging matters for behavior.
Multi-omics analysis reveals the dynamic interplay between Vero host chromatin structure and function during vaccinia virus infection
Authors: Venu Vrinda , Roth Cullen , Adikari Samantha H. , Small Eric M. , Starkenburg Shawn R. , Sanbonmatsu Karissa Y. , Steadman Christina R. 
Published: June 2024

AbstractThe genome folds into complex configurations and structures thought to profoundly impact its function. The intricacies of this dynamic structure-function relationship are not well understood particularly in the context of viral infection. To unravel this interplay, here we provide a comprehensive investigation of simultaneous host chromatin structural (via Hi-C and ATAC-seq) and functional changes (via RNA-seq) in response to vaccinia virus infection. Over time, infection significantly impacts global and local chromatin structure by increasing long-range intra-chromosomal interactions and B compartmentalization and by decreasing chromatin accessibility and inter-chromosomal interactions. Local accessibility changes are independent of broad-scale chromatin compartment exchange (~12% of the genome), underscoring potential independent mechanisms for global and local chromatin reorganization. While infection structurally condenses the host genome, there is nearly equal bidirectional differential gene expression. Despite global weakening of intra-TAD interactions, functional changes including downregulated immunity genes are associated with alterations in local accessibility and loop domain restructuring. Therefore, chromatin accessibility and local structure profiling provide impactful predictions for host responses and may improve development of efficacious anti-viral counter measures including the optimization of vaccine design.
Mechanistic analysis of enhancer sequences in the estrogen receptor transcriptional program
Authors: Tabe-Bordbar Shayan , Song You Jin , Lunt Bryan J. , Alavi Zahra , Prasanth Kannanganattu V. , Sinha Saurabh 
Published: June 2024

AbstractEstrogen Receptor α (ERα) is a major lineage determining transcription factor (TF) in mammary gland development. Dysregulation of ERα-mediated transcriptional program results in cancer. Transcriptomic and epigenomic profiling of breast cancer cell lines has revealed large numbers of enhancers involved in this regulatory program, but how these enhancers encode function in their sequence remains poorly understood. A subset of ERα-bound enhancers are transcribed into short bidirectional RNA (enhancer RNA or eRNA), and this property is believed to be a reliable marker of active enhancers. We therefore analyze thousands of ERα-bound enhancers and build quantitative, mechanism-aware models to discriminate eRNAs from non-transcribing enhancers based on their sequence. Our thermodynamics-based models provide insights into the roles of specific TFs in ERα-mediated transcriptional program, many of which are supported by the literature. We use in silico perturbations to predict TF-enhancer regulatory relationships and integrate these findings with experimentally determined enhancer-promoter interactions to construct a gene regulatory network. We also demonstrate that the model can prioritize breast cancer-related sequence variants while providing mechanistic explanations for their function. Finally, we experimentally validate the model-proposed mechanisms underlying three such variants.
Reconfigurable synthetic dimension frequency lattices in an integrated lithium niobate ring cavity
Authors: Dinh Hiep X. , Balčytis Armandas , Ozawa Tomoki , Ota Yasutomo , Ren Guanghui , Baba Toshihiko , Iwamoto Satoshi , Mitchell Arnan , Nguyen Thach G. 
Published: June 2024

AbstractHarnessing non-spatial properties of photons as if they represent an additional independent coordinate underpins the emerging synthetic dimension approach. It enables probing of higher-dimensional physical models within low-dimensional devices, such as on a planar chip where this method is relatively nascent. We demonstrate an integrated thin-film lithium niobate ring resonator that, under dynamic modulation, simulates a tight-binding model with its discrete frequency modes representing lattice sites. Inter-mode coupling, and the simulated lattice geometry, can be reconfigured by controlling the modulating signals. Up to a quasi-3D lattice connectivity with controllable gauge potentials has been achieved by simultaneous synchronized nearest-, second- and third-nearest-neighbor coupling, and verified by acquiring synthetic band structures. Development of synthetic frequency dimension devices in the thin-film lithium niobate photonic integration platform is a key step in increasing the complexity of topological models achievable on a chip, combining efficient electro-optic mode coupling with non-linear effects for long-range mode interactions.
Skillful seasonal prediction of wind energy resources in the contiguous United States
Authors: Yang Xiaosong , Delworth Thomas L. , Jia Liwei , Johnson Nathaniel C. , Lu Feiyu , McHugh Colleen 
Published: June 2024

AbstractA key challenge with the wind energy utilization is that winds, and thus wind power, are highly variable on seasonal to interannual timescales because of atmospheric variability. There is a growing need of skillful seasonal wind energy prediction for energy system planning and operation. Here we demonstrate model’s capability in producing skillful seasonal wind energy prediction over the U.S. Great Plains during peak energy seasons (winter and spring), using seasonal prediction products from a climate model. The dominant source of that skillful prediction mainly comes from year-to-year variations of El Niño-Southern Oscillation in the tropical Pacific, which alters large-scale wind and storm track patterns over the United States. In the Southern Great Plains, the model can predict strong year-to-year wind energy changes with high skill multiple months in advance. Thus, this seasonal wind energy prediction capability offers potential benefits for optimizing wind energy utilization during peak energy production seasons.
Mental health is positively associated with biodiversity in Canadian cities
Authors: Buxton Rachel T. , Hudgins Emma J. , Lavigne Eric , Villeneuve Paul J. , Prince Stephanie A. , Pearson Amber L. , Halsall Tanya , Robichaud Courtney , Bennett Joseph R. 
Published: June 2024

AbstractCities concentrate problems that affect human well-being and biodiversity. Exploring the link between mental health and biodiversity can inform more holistic public health and urban planning. Here we examined associations between bird and tree species diversity estimates from eBird community science datasets and national forest inventories with self-rated mental health metrics from the Canadian Community Health Survey. We linked data across 36 Canadian Metropolitan Areas from 2007-2022 at a postal code level. After controlling for covariates, we found that bird and tree species diversity were significantly positively related to good self-reported mental health. Living in a postal code with bird diversity one standard deviation higher than the mean increased reporting of good mental health by 6.64%. Postal codes with tree species richness one standard deviation more than the mean increased reporting of good mental health by 5.36%. Our results suggest that supporting healthy urban ecosystems may also benefit human well-being.
Considering clonal hematopoiesis of indeterminate potential in space radiation risk analysis for hematologic cancers and cardiovascular disease
Authors: Werneth Charles M. , Patel Zarana S. , Thompson Moriah S. , Blattnig Steve R. , Huff Janice L. 
Published: June 2024

Abstract
Background
Expanding human presence in space through long-duration exploration missions and commercial space operations warrants improvements in approaches for quantifying crew space radiation health risks. Currently, risk assessment models for radiogenic cancer and cardiovascular disease consider age, sex, and tobacco use, but do not incorporate other modifiable (e.g., body weight, physical activity, diet, environment) and non-modifiable individual risk factors (e.g., genetics, medical history, race/ethnicity, family history) that may greatly influence crew health both in-mission and long-term. For example, clonal hematopoiesis of indeterminate potential (CHIP) is a relatively common age-related condition that is an emerging risk factor for a variety of diseases including cardiovascular disease and cancer. CHIP carrier status may therefore exacerbate health risks associated with space radiation exposure.

Methods
In the present study, published CHIP hazard ratios were used to modify background hazard rates for coronary heart disease, stroke, and hematologic cancers in the National Aeronautics and Space Administration space radiation risk assessment model. The risk of radiation exposure-induced death for these endpoints was projected for a future Mars exploration mission scenario.

Results
Here we show appreciable increases in the lifetime risk of exposure-induced death for hematologic malignancies, coronary heart disease, and stroke, which are observed as a function of age after radiation exposure for male and female crew members that are directly attributable to the elevated health risks for CHIP carriers.

Conclusions
We discuss the importance of evaluating individual risk factors such as CHIP as part of a comprehensive space radiation risk assessment strategy aimed at effective risk communication and disease surveillance for astronauts embarking on future exploration missions.
The Feasibility of an Online Language Program Delivered Through Music and the Impact of Dosage on Vocabulary Outcomes in Young Children With Down Syndrome
Authors: Frizelle Pauline , McMullan Eva , Looney Eibhlín , Dahly Darren , O'Toole Ciara , Hart Nicola 
Published: June 2024

Background:
Few studies have explored the feasibility of online language interventions for young children with Down syndrome. Additionally, none have manipulated dose frequency or reported on the use of music as a medium through which language and sign can be learned.

Purpose:
The purpose of this study was to (a) examine the feasibility and acceptability of an online language through music intervention for young children (1–3;6 years) with Down syndrome and (b) compare effectiveness at two intervention dose frequencies.

Method:

The study was carried out in two phases using a mixed-methods design.
Phase 1:
Qualitative data were gathered from parents to examine feasibility when implementing a video-based language intervention.
Phase 2:
Seventy-six families participated in an online language intervention at home. Effectiveness was examined comparing two groups, randomly assigned to a high and low dose frequency. The Down Syndrome Education (DSE) checklists (combined) were the primary outcome measure. Process data were gathered to determine intervention acceptability in practice and to identify factors that would improve successful future implementation. Acceptability data were analyzed with reference to the theoretical framework of acceptability (Version 2).

Results:
Forty-three parents completed the Phase 1 scoping questionnaire, five of whom took part in focus groups. Once weekly morning sessions were indicated as the preferred scheduling choice. Phase 2 quantitative data were analyzed using beta regression adjusted for baseline scores and indicated no additional benefit to receiving the higher dose. However, exploratory interaction models suggested that the efficacy of the high-dose intervention was higher (than low-dose intervention) in participants with higher baseline DSE performance. Parents perceived the intervention to be effective and positive for the family.

Conclusion:
The results add to our knowledge of real-world effective online interventions and suggest that a critical minimum language level is required for children with Down syndrome to benefit optimally from a higher intervention dose frequency.

Supplemental Material:

https://doi.org/10.23641/asha.25979704