bluuebunny/crossref_metadata_2025_split huggingface dataset:
The self‐regulation of curiosity and interest during the information search process of adolescent students
Authors: Bowler Leanne 
Published: April 2010

AbstractIn a world of increasing information and communications possibilities, the difficulty for users of information systems and services may not lie in finding information but in filtering and integrating it into a cohesive whole. To do this, information seekers must know when and how to effectively use cognitive strategies to regulate their own thinking, motivation, and actions. Sometimes this is difficult when the topic is interesting and one is driven to explore it in great depth. This article reports on a qualitative study that, in the course of exploring the thinking and emotions of 10 adolescents during the information search process, uncovered patterns of behavior that are related to curiosity and interest. The larger purpose of the study was to investigate the metacognitive knowledge of adolescents, ages 16–18, as they searched for, selected, and used information to complete a school‐based information task. The study found that the curiosity experienced by adolescents during the search process was accompanied by feelings of both pleasure and pain and that both feelings needed to be managed in order to navigate a pathway through the search process. The self‐regulation of curiosity and interest was a clear and distinct metacognitive strategy fueled by metacognitive knowledge related to understanding one's own curiosity and the emotions attached to it.
Retracted:Conflict management in buyer‐seller relationships
Authors: Bobot Lionel 
Published: April 2010

AbstractThe following article from Conflict Resolution Quarterly, “Conflict Management in Buyer‐Seller Relationships,” by Lionel Bobot, published online on April 5, 2010 in Wiley Online Library (wileyonlinelibrary.com), and in Volume 27, No. 3, pp. 291‐319, has been retracted by agreement between the author, the journal Editor‐in‐Chief (Susan S. Raines), and Wiley Periodicals, Inc. The retraction has been agreed upon due to its similarities to the works listed below, which received insufficient attribution in the article.Bradford, K. D., and Weitz, B. A. “Salesperson's Management of Conflict in Buyer‐Seller Relationships,” Journal of Personal Selling & Sales Management, 2009, 29(1), 25‐42.Massey, G. R., and Dawes, P. L. “The Antecedents and Consequence of Functional and Dysfunctional Conflict Between Marketing Managers and Sales Managers.” Industrial Marketing Management, 2007, 36(8), 1118‐1129.
A crack in the foundation? Revisiting ECR's voluntary tenet
Authors: Wondolleck Julia M. 
Published: April 2010

AbstractVoluntary participation is a long‐standing tenet of environmental conflict resolution, prescribed at a time when the eventual reach and character of ECR could only be imagined. Today, ECR processes are ubiquitous, varied, and not always voluntary. Voluntary engagement involves choice and perception of fairness instilling commitment, good faith, respectful exchange, and legitimacy. These essential process qualities can be compromised if participation is mandated, yet mandates are sometimes necessary. This disconnect between theory and practice has been extensively examined for court‐connected ADR involving civil disputes, but not for ECR involving public disputes. Mediator experience with mandated ECR processes warrants attention.
California/Lomatiums, Part IX. Isolation of a new isomer of α‐sinensal and its derivatives from Lomatium mohavense ssp. longilobum
Authors: Beauchamp Philip S. , Dev V. , Kittisanthanon Khanittha , Ly Bill 
Published: April 2010

AbstractThe hydrodistilled oils from the fruits, stems and leaves of Lomatium mohavense ssp. longilobum were investigated. iso‐α‐Sinensal, iso‐α‐sinensol and iso‐α‐sinensyl actetate were isolated and their structures derived from their 2D NMR data.
The detection of circulating human papillomavirus‐specific T cells is associated with improved survival of patients with deeply infiltrating tumors
Authors: Heusinkveld Moniek , Welters Marij J.P. , van Poelgeest Mariette I.E. , van der Hulst Jeanette M. , Melief Cornelis J.M. , Fleuren Gert Jan J. , Kenter Gemma G. , van der Burg Sjoerd H. 
Published: April 2010

AbstractA detailed analyses of HPV‐specific immunity was performed in a large group of patients with HPV‐induced cervical cancer (CxCa) in relation to HLA‐types and prognostic factors. Patients were HLA‐typed and HPV16/18‐specific T‐cell immunity was assessed by proliferation assay and cytometric bead array using freshly isolated PBMC and by phenotypic analysis of HPV‐specific T cells. The results were analyzed in relation to known disease‐related HLA‐types (DR7, DR13, DR15/DQ06), invasion‐depth and size of tumor, lymph node (LN) status and disease free survival. In total 119 HLA‐typed patients with CxCa were analyzed. Patients expressing the HLA‐DR13 haplotype were underrepresented as compared to the Dutch population (p = 0.014), whereas HLA‐DR7 was overrepresented in patients with HPV16+ CxCa (p = 0.006). In 29 of 94 patients (31%) from whom blood could be tested, a proliferative response to HPV16/18 was detected, which was associated with increased numbers of HPV‐specific CD4+CD25+ (activated) T cells (p = 0.03) and HPV‐specific CD4+CD25+FoxP3‐positive T cells (p = 0.04). The presence of both FoxP3‐positive and negative HPV‐specific CD4+CD25+ T cells was significantly correlated (p = 0.01). Interestingly, the detection of HPV‐specific proliferation was associated with invasion depth (p = 0.020) but not with HLA type, tumor size nor LN status. Moreover, the detection of HPV‐specific immunity was associated with an improved disease free survival (p = 0.04) in patients with deeply infiltrating tumors. In conclusion, HPV‐specific proliferative T‐cell response, comprising higher percentages of HPV‐specific CD25+ and CD25+FoxP3‐positive CD4+T cells, are more frequently detected in patients with deep infiltrating CxCa tumors and associated with an improved survival.
Dysregulation of PRMT1 and PRMT6, Type I arginine methyltransferases, is involved in various types of human cancers
Authors: Yoshimatsu Masanori , Toyokawa Gouji , Hayami Shinya , Unoki Motoko , Tsunoda Tatsuhiko , Field Helen I. , Kelly John D. , Neal David E. , Maehara Yoshihiko , Ponder Bruce A.J. , Nakamura Yusuke , Hamamoto Ryuji 
Published: April 2010

AbstractProtein arginine methylation is a novel post‐translational modification regulating a diversity of cellular processes, including histone functions, but the roles of protein arginine methyltransferases (PRMTs) in human cancer are not well investigated. To address this issue, we first examined expression levels of genes belonging to the PRMT family and found significantly higher expression of PRMT1 and PRMT6, both of which are Type I PRMTs, in cancer cells of various tissues than in non‐neoplastic cells. Abrogation of the expression of these genes with specific siRNAs significantly suppressed growth of bladder and lung cancer cells. Expression profile analysis using the cells transfected with the siRNAs indicated that PRMT1 and PRMT6 interplay in multiple pathways, supporting regulatory roles in the cell cycle, RNA processing and also DNA replication that are fundamentally important for cancer cell proliferation. Furthermore, we demonstrated that serum asymmetric dimethylarginine (ADMA) levels of a number of cancer cases are significantly higher than those of nontumor control cases. In summary, our results suggest that dysregulation of PRMT1 and PRMT6 can be involved in human carcinogenesis and that these Type I arginine methyltransferases are good therapeutic targets for various types of cancer.
Downregulation of survivin and aurora A by histone deacetylase and RAS inhibitors: A new drug combination for cancer therapy
Authors: Biran Anat , Brownstein Michael , Haklai Ronit , Kloog Yoel 
Published: April 2010

AbstractHistone deacetylase (HDAC) inhibitors, such as valproic acid (VPA), constitute a novel class of anticancer agents that cause an increase in acetylated histones and thus restore the expression of dormant tumor‐suppressor and other genes related to cell differentiation, cell‐cycle arrest or apoptosis of tumor cells. The Ras inhibitor farnesylthiosalicylic acid (FTS, salirasib) attenuates cancer cell proliferation in vitro and in vivo and, under certain circumstances, induces cell death. FTS by itself does not induce differentiation or complete growth arrest. The abovementioned activity of VPA as a differentiation agent suggested that it might be worth investigating its possible therapeutic potential in synergistic combination with FTS. Here, we examined whether the combined application of VPA and FTS could synergistically inhibit the proliferation of cancer cells that express oncogenic K‐Ras (A549 nonsmall‐cell lung carcinoma cells), DLD1 (colon carcinoma cells) or chronically active wild‐type K‐Ras and constitutively active B‐Raf (ARO, thyroid carcinoma cells). The results showed that combined treatment with VPA and FTS synergistically reduces proliferation in all of these cancer cell lines by downregulating Ras and blocking the expression of Survivin and Aurora A. These alterations, which were most pronounced following the combined treatment, led to a mitotic crisis, as reflected by mislocalization of the chromosomal passenger complex. Our findings thus demonstrate that combination therapy with VPA and FTS might offer a promising therapeutic approach to the treatment of epithelial tumors.
Results of the three rounds of the Finnish Prostate Cancer Screening Trial—The incidence of advanced cancer is decreased by screening
Authors: Kilpeläinen Tuomas P. , Auvinen Anssi , Määttänen Liisa , Kujala Paula , Ruutu Mirja , Stenman Ulf‐Håkan , Tammela Teuvo L.J. 
Published: April 2010

AbstractScreening for prostate cancer (PC) remains a controversial issue despite some new evidence on the mortality benefits of PC screening. We conducted a prospective, randomized screening trial in Finland to investigate whether screening decreases PC incidence. Here, we report the incidence results from three screening rounds during a 12‐year period. Of the 80,144 men enrolled, 31,866 men were randomized to the screening arm (SA) and invited for screening with prostate‐specific antigen test (cut‐off 4.0 ng/ml) every 4 years, while the remaining men formed the control arm (CA) that received no interventions. The mean follow‐up time for PC incidence in both arms was over 9 years. The incidence rate of PC (including screen‐detected and interval cancers as well as cases among nonparticipants) was 9.1 per 1,000 person‐years in the SA and 6.2 in the CA, yielding an incidence rate ratio (IRR) 1.5 (95% confidence interval 1.4–1.5). The incidence of advanced PC was 1.1 in the SA and 1.5 in the CA, IRR = 0.7 (0.6–0.8) and the difference emerges after 5–6 years of follow‐up. The incidence of localized PC was 7.5 in the SA and 4.6 in the CA, IRR = 1.6 (1.5–1.7). The results from our large population‐based trial indicate that screening for PC decreases the incidence of advanced PC. When compared with the CA, the PC detected in the SA there were substantially more often localized, low‐grade PCs due to overdiagnosis.
Serum sHLA‐G levels: A useful indicator in distinguishing colorectal cancer from benign colorectal diseases
Authors: Zhu Cheng‐Bao , Wang Chuan‐Xin , Zhang Xin , Zhang Jian , Li Wei 
Published: April 2010

AbstractSoluble human leukocyte antigen‐G (sHLA‐G) has been reported in malignancies and is implicated in mediating immune surveillance of tumor. The aim of our study is to detect serum sHLA‐G levels in colorectal cancer and to determine whether sHLA‐G may be helpful in distinguishing colorectal cancer from benign colorectal diseases. Serum sHLA‐G levels were determined using enzyme‐linked immunosorbent assay. Receiver operating characteristic (ROC) curve was used to evaluate the feasibility of sHLA‐G in differentiating colorectal cancer from benign colorectal diseases. Median sHLA‐G concentrations were significantly higher in colorectal cancer compared to normal colorectum, hyperplastic polyp, inflammatory bowel disease and adenoma (all at p < 0.001, respectively). ROC curve for sHLA‐G revealed an area under the curve of 84.2%, and when 88.6 U/mL was used as cutoff, a sensitivity of 72.2% and a specificity of 87.8% were achieved. Comparison of sHLA‐G and carcinoembryogenic antigen ROC curves indicated that sHLA‐G was superior to CEA in differentiating colorectal cancer from benign colorectal diseases (p < 0.001). ROC curves analysis of the combined sHLA‐G and CEA showed a higher detection capacity (area under the ROC curve, 87.4%) than that of markers considered singly. These findings reveal that serum levels of sHLA‐G are significantly increased in colorectal cancer which may serve as a potent mediator of immune escape in colorectal cancer, and sHLA‐G may be a useful indicator in differentiating colorectal cancer from benign colorectal diseases.
Circulating miRNAs are correlated with tumor progression in prostate cancer
Authors: Brase Jan C. , Johannes Marc , Schlomm Thorsten , Fälth Maria , Haese Alexander , Steuber Thomas , Beissbarth Tim , Kuner Ruprecht , Sültmann Holger 
Published: April 2010

AbstractCirculating miRNAs have recently been indicated as practicable and promising biomarkers for noninvasive diagnosis in various tumor entities. However, cell‐free miRNAs have not been found to correlate with clinicopathological variables in epithelial carcinomas. To learn more about the potential clinical relevance of circulating miRNAs in prostate cancer, we screened 667 miRNAs in serum samples from patients with metastatic (n= 7) and localized prostate cancer (n= 14). Various miRNAs were highly abundant in the sera of patients with metastatic disease, and five upregulated miRNAs (miRNA‐375, miRNA‐9*, miRNA‐141, miRNA‐200bandmiRNA‐516a‐3p) were selected for further validation. In the first validation study (n= 45), selected miRNAs were analyzed in a prospectively collected serum set taken from different prostate cancer risk groups. Most of the selected miRNAs were significantly correlated with adverse risk factors when different clinicopathological variables were analyzed. CirculatingmiRNA‐375andmiRNA‐141turned out to be the most pronounced markers for high‐risk tumors. Their levels also correlated with high Gleason score or lymph‐node positive status in a second independent validation study (n= 71). In addition, the expression levels ofmiRNA‐375andmiRNA‐141were monitored in 72 prostate tissue samples (36 tumorvs. 36 benign). Both miRNAs were highly expressed in all samples and significantly upregulated in the tumors compared to normal tissues. Overall, our observations suggest thatmiRNA‐375andmiRNA‐141expression is enhanced in prostate cancer specimens and their release into the blood is further associated with advanced cancer disease.
β‐Catenin—A supporting role in the skeleton
Authors: Case Natasha , Rubin Janet 
Published: April 2010

AbstractIn the last 5 years a role for β‐catenin in the skeleton has been cemented. Beginning with mutations in the Lrp5 receptor that control β‐catenin canonical downstream signals, and progressing to transgenic models with bone‐specific alteration of β‐catenin, research has shown that β‐catenin is required for normal bone development. A cell critical to bone in which β‐catenin activity determines function is the marrow‐derived mesenchymal stem cell (MSC), where sustained β‐catenin prevents its distribution into adipogenic lineage. β‐Catenin actions are less well understood in mature osteoblasts: while β‐catenin contributes to control of osteoclastic bone resorption via alteration of the osteoprotegerin/RANKL ratio, a specific regulatory role during osteoblast bone synthesis has not yet been determined. The proven ability of mechanical factors to prevent β‐catenin degradation and induce nuclear translocation through Lrp‐independent mechanisms suggests processes by which exercise might modulate bone mass via control of lineage allocation, in particular, by preventing precursor distribution into the adipocyte pool. Effects resulting from mechanical activation of β‐catenin in mature osteoblasts and osteocytes likely modulate bone resorption, but whether β‐catenin is involved in osteoblast synthetic function remains to be proven for both mechanical and soluble mediators. As β‐catenin appears to support the downstream effects of multiple osteogenic factors, studies clarifying when and where β‐catenin effects occur will be relevant for translational approaches aimed at preventing bone loss and terminal adipogenic conversion. J. Cell. Biochem. 110: 545–553, 2010. © 2010 Wiley‐Liss, Inc.
Analysis of hairless corepressor mutants to characterize molecular cooperation with the vitamin D receptor in promoting the mammalian hair cycle
Authors: Hsieh Jui‐Cheng , Slater Stephanie A. , Whitfield G. Kerr , Dawson Jamie L. , Hsieh Grace , Sheedy Craig , Haussler Carol A. , Haussler Mark R. 
Published: April 2010

AbstractThe mammalian hair cycle requires both the vitamin D receptor (VDR) and the hairless (Hr) corepressor, each of which is expressed in the hair follicle. Hr interacts directly with VDR to repress VDR‐targeted transcription. Herein, we further map the VDR‐interaction domain to regions in the C‐terminal half of Hr that contain two LXXLL‐like pairs of motifs known to mediate contact of Hr with the RAR‐related orphan receptor alpha and with the thyroid hormone receptor, respectively. Site‐directed mutagenesis indicates that all four hydrophobic motifs are required for VDR transrepression by Hr. Point mutation of rat Hr at conserved residues corresponding to natural mutants causing alopecia in mice (G985W and a C‐terminal deletion ΔAK) and in humans (P95S, C422Y, E611G, R640Q, C642G, N988S, D1030N, A1040T, V1074M, and V1154D), as well as alteration of residues in the C‐terminal Jumonji C domain implicated in histone demethylation activity (C1025G/E1027G and H1143G) revealed that all Hr mutants retained VDR association, and that transrepressor activity was selectively abrogated in C642G, G985W, N988S, D1030N, V1074M, H1143G, and V1154D. Four of these latter Hr mutants (C642G, N988S, D1030N, and V1154D) were found to associate normally with histone deacetylase‐3. Finally, we identified three regions of human VDR necessary for association with Hr, namely residues 109–111, 134–201, and 202–303. It is concluded that Hr and VDR interact via multiple protein–protein interfaces, with Hr recruiting histone deacetylases and possibly itself catalyzing histone demethylation to effect chromatin remodeling and repress the transcription of VDR target genes that control the hair cycle. J. Cell. Biochem. 110: 671–686, 2010. © 2010 Wiley‐Liss, Inc.
Role of ERK1/2 in platelet lysate‐driven endothelial cell repair
Authors: Ranzato Elia , Boccafoschi Francesca , Mazzucco Laura , Patrone Mauro , Burlando Bruno 
Published: April 2010

AbstractMechanisms of endothelial repair induced by a platelet lysate (PL) were studied on human (HuVEC, HMVEC‐c) and non‐human (PAOEC, bEnd5) endothelial cells. A first set of analyses on these cells showed that 20% (v/v) PL promotes scratch wound healing, with a maximum effect on HuVEC. Further analyses made on HuVEC showed that the ERK inhibitor PD98059 maximally inhibited the PL‐induced endothelial repair, followed in order of importance by the calcium chelator BAPTA‐AM, the PI3K inhibitor wortmannin and the p38 inhibitor SB203580. The PL exerted a chemotactic effect on HuVEC, which was abolished by all the above inhibitors, and induced a PD98059‐sensitive increase of cell proliferation rate. Confocal calcium imaging of fluo‐3‐loaded HuVEC showed that PL was able to induce cytosolic free Ca2+ oscillations, visible also in Ca2+‐free medium, suggesting an involvement of Ins3P‐dependent Ca2+ release. Western blot analysis on scratch wounded HuVEC showed that PL induced no activation of p38, a transient activation of AKT, and a sustained activation of ERK1/2. The complex of data indicates that, although different signalling pathways are involved in PL‐promoted endothelial repair, the process is chiefly under the control of ERK1/2. J. Cell. Biochem. 110: 783–793, 2010. © 2010 Wiley‐Liss, Inc.
Over‐expression of EDAG in the myeloid cell line 32D: Induction of GATA‐1 expression and erythroid/megakaryocytic phenotype
Authors: Ding Ya‐li , Xu Cheng‐Wang , Wang Zhi‐Dong , Zhan Yi‐Qun , Li Wei , Xu Wang‐Xiang , Yu Miao , Ge Chang‐Hui , Li Chang‐Yan , Yang Xiao‐Ming 
Published: April 2010

AbstractErythroid differentiation‐associated gene (EDAG), a hematopoietic tissue‐specific transcription regulator, plays a key role in maintaining the homeostasis of hematopoietic lineage commitment. However, the mechanism and genes regulated by EDAG remain unknown. In this study, we showed that overexpression of EDAG in a myeloid cell line 32D led to an erythroid phenotype with increased number of benzidine‐positive cells and up‐regulation of erythroid specific surface marker TER119. The megakaryocytic specific marker CD61 was also induced significantly. Using a genome‐wide microarray analysis and a twofold change cutoff, we identified 332 genes with reduced expression and 288 genes with increased expression. Among up‐regulation genes, transcription factor GATA‐1 and its target genes including EKLF, NF‐E2, Gfi‐1b, hemogen, SCL, hemoglobin alpha, beta and megakaryocytic gene GPIX were increased. Silencing of EDAG by RNA interference in K562 cells resulted in down‐regulation of these genes. Taken together, EDAG functions as a positive regulator of erythroid/megakaryocytic differentiation in 32D cells associated with the induction of GATA‐1 and its target genes. J. Cell. Biochem. 110: 866–874, 2010. © 2010 Wiley‐Liss, Inc.
Multidimensional assessment of OCD: integration and revision of the vancouver obsessional‐compulsive inventory and the symmetry ordering and arranging questionnaire
Authors: Gönner Sascha , Ecker Willi , Leonhart Rainer , Limbacher Klaus 
Published: April 2010

AbstractThis article reports on the integration and revision of two self‐report measures of obsessive‐compulsive symptoms based on data from an obsessive‐compulsive disorder (OCD) sample (n=228): the Vancouver Obsessional‐Compulsive Inventory (VOCI) and the Symmetry Ordering and Arranging Questionnaire (SOAQ). The revised measure provides scores on five symptom subscales (Contamination, Checking, Hoarding, Symmetry and Ordering, Obsessions). It shows improvement upon current versions in several ways: it has a good model fit, eliminates redundancy, reduces overlap across subscales, is much shorter, and covers those OCD dimensions most frequently identified in factor‐analytic studies. Strengths of the revision compared with other measures are high distinctiveness of subscales, discriminant validity with depression and anxiety, and a more fine‐grained and comprehensive assessment of obsessional contents. © 2010 Wiley Periodicals, Inc. J Clin Psychol: 66:1–19, 2010.