bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Regional Climatology of Monsoonal Precipitation in the Southwestern United States Using TRMM
Authors: Wall Christina L. , Zipser Edward J. , Liu Chuntao 
Published: August 2011

Abstract
Using 13 yr of data from the Tropical Rainfall Measuring Mission (TRMM) satellite, a regional climatology of monsoonal precipitation is created for portions of the southwest United States. The climatology created using precipitation features defined from the TRMM precipitation radar (PR) shows that the population of features includes a large number of small, weak features that do not produce much rain and are very shallow. A lesser percentage of large, stronger features contributes most of the region’s rainfall. Dividing the features into categories based on the median values of volumetric rainfall and maximum height of the 30-dBZ echo is a useful way to visualize the population of features, and the categories selected reflect the life cycle of monsoonal convection. An examination of the top rain-producing features at different elevations reveals that extreme features tend to occur at lower elevations later in the day. A comparison with the region studied in the North American Monsoon Experiment (NAME) shows that similar diurnal patterns occur in the Sierra Madre Occidental region of Mexico. The population of precipitation features in both regions is similar, with the NAME region producing slightly larger precipitation systems on average than the southwest United States. Both regions on occasion demonstrate the pattern of convection initiating at high elevations and moving downslope while growing upscale through the afternoon and evening; however, there are also days on which convection remains over the high terrain.
Large Seasonal Modulation of Tides due to Ice Cover Friction in a Midlatitude Estuary*
Authors: Georgas Nickitas 
Published: August 2011

Abstract
Seasonal episodes of significant tidal damping (reductions of tidal amplitudes as much as 50%) and tidal modulation were observed in the Hudson River estuary in the course of three consecutive winters from multiple tide gages. Through comparisons with United States Coast Guard ice reports, it was hypothesized that these events correspond with an increase in ice concentration and the development of a seasonal ice field within the upper 170 km of the tidal Hudson north of Peekskill, New York. Using stationary (tidal harmonic) and nonstationary (wavelet) analyses as well as numerical modeling, it is shown that under-ice friction is the primary cause of the observed modulations in tidal circulation (water levels and currents) throughout the 240-km-long estuary. Upstream of the ice field edge at Peekskill, depth-averaged tidal currents are greatly reduced under the ice cover through first-order damping, and vertical current profiles under the ice become parabolic. Tidal ranges increase near the edge of the ice field, and, south of that, on Manhattan’s western shores, currents increase because of tidal wave reflection. These amplified currents create stronger vertical mixing leading to a less stratified estuary and decreasing salt front intrusion. At the other end, near Troy, tidal flows become smaller relative to the river’s streamflow, leading to increased ebb predominance and ebb-directed flows down to the port of Albany. Also, the increased friction leads to a higher sea level setup there. During such episodes, astronomical tide–based and operational forecast model predictions that neglected ice are severely compromised.
Clinical and Ultrasonographic Results of Ultrasonographically Guided Percutaneous Radiofrequency Lesioning in the Treatment of Recalcitrant Lateral Epicondylitis
Authors: Lin Cheng-Li , Lee Jung-Shun , Su Wei-Ren , Kuo Li-Chieh , Tai Ta-Wei , Jou I-Ming 
Published: August 2011

Background: In patients with lateral epicondylitis recalcitrant to nonsurgical treatments, surgical intervention is considered. Despite the numerous therapies reported, the current trend of treatment places particular emphasis on minimally invasive techniques. Purpose: The authors present a newly developed minimally invasive procedure, ultrasonographically guided percutaneous radiofrequency thermal lesioning (RTL), and its clinical efficacy in treating recalcitrant lateral epicondylitis. Study Design: Case series: Level of evidence, 4. Methods: Thirty-four patients (35 elbows), with a mean age of 52.1 years (range, 35-65 years), suffered from symptomatic lateral epicondylitis for more than 6 months and had exhausted nonoperative therapies. They were treated with ultrasonographically guided RTL. Patients were followed up at least 6 months by physical examination and 12 months by interview. The intensity of pain was recorded with a visual analog scale (VAS) score. The functional outcome was evaluated using grip strength, the upper limb Disability of Arm, Shoulder and Hand (QuickDASH) outcome measure, and the Modified Mayo Clinic Performance Index (MMCPI) for the elbow. The ultrasonographic findings regarding the extensor tendon origin were recorded, as were the complications. Results: At the time of the 6-month follow-up, the average VAS score in resting (from 4.9 to 0.9), palpation (from 7.6 to 2.5), and grip (from 8.2 to 2.9) had improved significantly compared with the preoperative condition ( P < .01). The grip strength (from 20.6 to 27.0 kg) and QuickDASH score (from 54.3 to 21.0) had also improved significantly ( P < .01). The MMCPI score improved from “poor” to “excellent.” The ultrasonographic finding revealed that the thickness of the common extensor tendon origin did not change significantly. At the final follow-up (mean, 14.3 months; range, 12-21 months), the patients reported a 78% reduction in pain compared with the preoperative status. No major complications were noted in any patient. Conclusion: Ultrasonographically guided RTL for recalcitrant lateral epicondylitis was found to be a minimally invasive treatment with satisfactory results in this pilot investigation. This innovative method can be considered as an alternative treatment of recalcitrant lateral epicondylitis before further surgical intervention.
IFN-γ promotes graft-versus-leukemia effects without directly interacting with leukemia cells in mice after allogeneic hematopoietic cell transplantation
Authors: Yang Yanping , Wang Hui , Yu Hui , Yeap Beow Yong , Liang Tingting , Wang Guanjun , Cheng Tao , Yang Yong-Guang 
Published: August 2011

AbstractThe ability of IFN-γ to enhance graft-versus-leukemia (GVL) activity without direct interaction with leukemia cells was examined by comparing GVL effects against IFN-γ receptor-deficient (GRKO) leukemia between wild-type (WT) and IFN-γ–deficient (GKO) allogeneic hematopoietic cell transplantation (allo-HCT). We established a primary IFN-γ–unresponsive T-cell leukemia model using virally-transduced GRKO B6 mouse bone marrow cells overexpressing Notch1. We first assessed GVL effects in lethally-irradiated B6 mice receiving CD4-depleted allo-HCT from WT or GKO BALB/c donors. Administration of CD4+ cell-depleted allo-HCT from WT, but not GKO, BALB/c donors mediated significant GVL effects against GRKO leukemia. Similar results were obtained in pre-established allogeneic chimeras receiving delayed donor lymphocyte infusion (DLI). Although both WT and GKO DLI achieved significant anti-tumor responses, the former was markedly stronger than the latter. These data indicate that IFN-γ is capable of promoting GVL effects via mechanisms independent of its interaction with leukemia cells.
Pediatric-inspired intensified therapy of adult T-ALL reveals the favorable outcome of NOTCH1/FBXW7 mutations, but not of low ERG/BAALC expression: a GRAALL study
Authors: Ben Abdelali Raouf , Asnafi Vahid , Leguay Thibaut , Boissel Nicolas , Buzyn Agnès , Chevallier Patrice , Thomas Xavier , Lepretre Stephane , Huguet Françoise , Vey Norbert , Escoffre-Barbe Martine , Tavernier Emmanuelle , Reman Oumedaly , Fegueux Nathalie , Turlure Pascal , Rousselot Philippe , Cahn Jean-Yves , Lheritier Veronique , Chalandon Yves , Béné Marie-Christine , Macintyre Elizabeth , Dombret Hervé , Ifrah Norbert ,   for the Group for Research on Adult Acute Lymphoblastic Leukemia
Published: August 2011

Abstract
Despite recent progress in the understanding of acute lymphoblastic leukemia (T-ALL) oncogenesis, few markers are sufficiently frequent in large subgroups to allow their use in therapeutic stratification. Low ERG and BAALC expression (E/Blow) and NOTCH1/FBXW7 (N/F) mutations have been proposed as powerful prognostic markers in large cohorts of adult T-ALL. We therefore compared the predictive prognostic value of N/F mutations versus E/Blow in 232 adult T-ALLs enrolled in the LALA-94 and Group for Research on Adult Acute Lymphoblastic Leukemia (GRAALL) protocols. The outcome of T-ALLs treated in the pediatric-inspired GRAALL trials was significantly superior to the LALA-94 trial. Overall, 43% and 69% of adult T-ALL patients were classified as E/Blow and N/F mutated, respectively. Strikingly, the good prognosis of N/F mutated patients was stronger in more intensively treated, pediatric-inspired GRAALL patients. The E/B expression level did not influence the prognosis in any subgroup. N/F mutation status and the GRAALL trial were the only 2 independent factors that correlated with longer overall survival by multivariate analysis. This study demonstrates that the N/F mutational status and treatment protocol are major outcome determinants for adults with T-ALL, the benefit of pediatric inspired protocols being essentially restricted to the N/F mutated subgroup.
Engineered blood vessel networks connect to host vasculature via wrapping-and-tapping anastomosis
Authors: Cheng Gang , Liao Shan , Kit Wong Hon , Lacorre Delphine A. , di Tomaso Emmanuelle , Au Patrick , Fukumura Dai , Jain Rakesh K. , Munn Lance L. 
Published: August 2011

Abstract
Rapid blood perfusion is critical for postimplantation survival of thick, prevascularized bioartificial tissues. Yet the mechanism by which implanted vascular networks inosculate, or anastomose, with the host vasculature has been unknown, making it difficult to develop optimized strategies for facilitating perfusion. Here we show that implanted vascular networks anastomose with host vessels through a previously unidentified process of “wrapping and tapping” between the engrafted endothelial cells (ECs) and the host vasculature. At the host-implant interface, implanted ECs first wrap around nearby host vessels and then cause basement membrane and pericyte reorganization and localized displacement of the underlying host endothelium. In this way, the implanted ECs replace segments of host vessels to divert blood flow to the developing implanted vascular network. The process is facilitated by high levels of matrix metalloproteinase-14 and matrix metalloproteinase-9 expressed by the wrapping ECs. These findings open the door to new strategies for improving perfusion of tissue grafts and may have implications for other physiologic and pathologic processes involving postnatal vasculogenesis.
Aspirin or enoxaparin thromboprophylaxis for patients with newly diagnosed multiple myeloma treated with lenalidomide
Authors: Larocca Alessandra , Cavallo Federica , Bringhen Sara , Di Raimondo Francesco , Falanga Anna , Evangelista Andrea , Cavalli Maide , Stanevsky Anfisa , Corradini Paolo , Pezzatti Sara , Patriarca Francesca , Cavo Michele , Peccatori Jacopo , Catalano Lucio , Carella Angelo Michele , Cafro Anna Maria , Siniscalchi Agostina , Crippa Claudia , Petrucci Maria Teresa , Yehuda Dina Ben , Beggiato Eloise , Di Toritto Tommaso Caravita , Boccadoro Mario , Nagler Arnon , Palumbo Antonio 
Published: August 2011

Abstract
Lenalidomide plus dexamethasone is effective in the treatment of multiple myeloma (MM) but is associated with an increased risk of venous thromboembolism (VTE). This prospective, open-label, randomized substudy of a phase 3 trial compared the efficacy and safety of thromboprophylaxis with low-dose aspirin (ASA) or low-molecular-weight heparin (LMWH) in patients with newly diagnosed MM, treated with lenalidomide and low-dose dexamethasone induction and melphalan-prednisone-lenalidomide consolidation. Overall, 342 patients who did not have clinical indications or contraindications to antiplatelet or anticoagulant therapy were randomly assigned to receive ASA 100 mg/d (n = 176) or LMWH enoxaparin 40 mg/d (n = 166). The incidence of VTE was 2.27% in the ASA group and 1.20% in the LMWH group. Compared with LMWH, the absolute difference in the proportion of VTE was 1.07% (95% confidence interval, −1.69-3.83; P = .452) in the ASA group. Pulmonary embolism was observed in 1.70% of patients in the ASA group and none in the LMWH group. No arterial thrombosis, acute cardiovascular events, or sudden deaths were reported. No major hemorrhagic complications were reported. In previously untreated patients with MM receiving lenalidomide with a low thromboembolic risk, ASA could be an effective and less-expensive alternative to LMWH thromboprophylaxis. This study was registered at www.clinicaltrials.gov as #NCT00551928.
The CXCR4 antagonist plerixafor is a potential therapy for myelokathexis, WHIM syndrome
Authors: Dale David C. , Bolyard Audrey Anna , Kelley Merideth L. , Westrup Ernest C. , Makaryan Vahagn , Aprikyan Andrew , Wood Brent , Hsu Frank J. 
Published: August 2011

Abstract
Mutations in CXCR4 cause severe leukopenia in myelokathexis or WHIM syndrome. Plerixafor inhibits binding of CXCR4 to its ligand CXCL12. We investigated the effects of plerixafor (0.04 to 0.24 mg/kg) administered at 2-4 day intervals in 6 patients. Outcome measures were the patients' complete blood cell counts, CD34+ cell counts and lymphocyte subtypes compared with 5 normal subjects similarly treated with plerixafor. All patients showed prompt leukocytosis with maximum blood neutrophils and lymphocytes at 6-12 hours. Blood neutrophils peaked at 6-12 hours, increasing from a mean baseline of 0.4 ± 0.1 × 109/L, to mean peak of 4.5 ± 0.78 × 109/L. Lymphocytes also increased; the greatest increase was in B cells (CD19+ cells), a > 40-fold increase over baseline at the 0.08 mg/kg dose. None of the patients experienced any significant adverse effects. Plerixafor is a promising therapy for this condition.
Predicting receptor-ligand pairs through kernel learning
Authors: Iacucci Ernesto , Ojeda Fabian , De Moor Bart , Moreau Yves 
Published: August 2011

Abstract

Background
Regulation of cellular events is, often, initiated via extracellular signaling. Extracellular signaling occurs when a circulating ligand interacts with one or more membrane-bound receptors. Identification of receptor-ligand pairs is thus an important and specific form of PPI prediction.

Results
Given a set of disparate data sources (expression data, domain content, and phylogenetic profile) we seek to predict new receptor-ligand pairs. We create a combined kernel classifier and assess its performance with respect to the Database of Ligand-Receptor Partners (DLRP) 'golden standard' as well as the method proposed by Gertz et al. Among our findings, we discover that our predictions for the tgfβ family accurately reconstruct over 76% of the supported edges (0.76 recall and 0.67 precision) of the receptor-ligand bipartite graph defined by the DLRP "golden standard". In addition, for the tgfβ family, the combined kernel classifier is able to relatively improve upon the Gertz et al. work by a factor of approximately 1.5 when considering that our method has an F-measure of 0.71 while that of Gertz et al. has a value of 0.48.

Conclusions
The prediction of receptor-ligand pairings is a difficult and complex task. We have demonstrated that using kernel learning on multiple data sources provides a stronger alternative to the existing method in solving this task.
Family structure and phylogenetic analysis of odorant receptor genes in the large yellow croaker (Larimichthys crocea)
Authors: Zhou Yingsong , Yan Xiaojun , Xu Shanliang , Zhu Peng , He Xianxing , Liu Jianxin 
Published: August 2011

Abstract

Background
Chemosensory receptors, which are all G-protein-coupled receptors (GPCRs), come in four types: odorant receptors (ORs), vomeronasal receptors, trace-amine associated receptors and formyl peptide receptor-like proteins. The ORs are the most important receptors for detecting a wide range of environmental chemicals in daily life. Most fish OR genes have been identified from genome databases following the completion of the genome sequencing projects of many fishes. However, it remains unclear whether these OR genes from the genome databases are actually expressed in the fish olfactory epithelium. Thus, it is necessary to clone the OR mRNAs directly from the olfactory epithelium and to examine their expression status.

Results
Eighty-nine full-length and 22 partial OR cDNA sequences were isolated from the olfactory epithelium of the large yellow croaker, Larimichthys crocea. Bayesian phylogenetic analysis classified the vertebrate OR genes into two types, with several clades within each type, and showed that the L. crocea OR genes of each type are more closely related to those of fugu, pufferfish and stickleback than they are to those of medaka, zebrafish and frog. The reconciled tree showed 178 duplications and 129 losses. The evolutionary relationships among OR genes in these fishes accords with their evolutionary history. The fish OR genes have experienced functional divergence, and the different clades of OR genes have evolved different functions. The result of real-time PCR shows that different clades of ORs have distinct expression levels.

Conclusion
We have shown about 100 OR genes to be expressed in the olfactory epithelial tissues of L. crocea. The OR genes of modern fishes duplicated from their common ancestor, and were expanded over evolutionary time. The OR genes of L. crocea are closely related to those of fugu, pufferfish and stickleback, which is consistent with its evolutionary position. The different expression levels of OR genes of large yellow croaker may suggest varying roles of ORs in olfactory function.
Genomic insights into the versatility of the plant growth-promoting bacterium Azospirillum amazonense
Authors: Sant'Anna Fernando H , Almeida Luiz GP , Cecagno Ricardo , Reolon Luciano A , Siqueira Franciele M , Machado Maicon RS , Vasconcelos Ana TR , Schrank Irene S 
Published: August 2011

AbstractBackgroundThe speciesAzospirillum amazonensebelongs to a well-known genus of plant growth-promoting bacteria. This bacterium is found in association with several crops of economic importance; however, there is a lack of information on its physiology. In this work, we present a comprehensive analysis of the genomic features of this species.ResultsGenes ofA. amazonenserelated to nitrogen/carbon metabolism, energy production, phytohormone production, transport, quorum sensing, antibiotic resistance, chemotaxis/motility and bacteriophytochrome biosynthesis were identified. Noteworthy genes were the nitrogen fixation genes and the nitrilase gene, which could be directly implicated in plant growth promotion, and the carbon fixation genes, which had previously been poorly investigated in this genus. One important finding was that someA. amazonensegenes, like the nitrogenase genes and RubisCO genes, were closer phylogenetically to Rhizobiales members than to species of its own order.ConclusionThe speciesA. amazonensepresents a versatile repertoire of genes crucial for its plant-associated lifestyle.
Identification of α-Chimaerin as a Candidate Gene for Critical Period Neuronal Plasticity in Cat and Mouse Visual Cortex
Authors: Yang Cui Bo , Zheng Yu Ting , Kiser Paul J , Mower George D 
Published: August 2011

Abstract

Background
In cat visual cortex, critical period neuronal plasticity is minimal until approximately 3 postnatal weeks, peaks at 5 weeks, gradually declines to low levels at 20 weeks, and disappears by 1 year of age. Dark rearing slows the entire time course of this critical period, such that at 5 weeks of age, normal cats are more plastic than dark reared cats, whereas at 20 weeks, dark reared cats are more plastic. Thus, a stringent criterion for identifying genes that are important for plasticity in visual cortex is that they show differences in expression between normal and dark reared that are of opposite direction in young versus older animals.

Results
The present study reports the identification by differential display PCR of a novel gene, α-chimaerin, as a candidate visual cortex critical period plasticity gene that showed bidirectional regulation of expression due to age and dark rearing. Northern blotting confirmed the bidirectional expression and 5'RACE sequencing identified the gene. There are two alternatively-spliced α-chimaerin isoforms: α1 and α2. Western blotting extended the evidence for bidirectional regulation of visual cortex α-chimaerin isoform expression to protein in cats and mice. α1- and α2-Chimaerin were elevated in dark reared compared to normal visual cortex at the peak of the normal critical period and in normal compared to dark reared visual cortex at the nadir of the normal critical period. Analysis of variance showed a significant interaction in both cats and mice for both α-chimaerin isoforms, indicating that the effect of dark rearing depended on age. This differential expression was not found in frontal cortex.

Conclusions
Chimaerins are RhoGTPase-activating proteins that are EphA4 effectors and have been implicated in a number of processes including growth cone collapse, axon guidance, dendritic spine development and the formation of corticospinal motor circuits. The present results identify α-chimaerin as a candidate molecule for a role in the postnatal critical period of visual cortical plasticity.