bluuebunny/crossref_metadata_2025_split huggingface dataset:
Differential Tumor Gene Expression Profiling of Patients With Prostate Adenocarcinoma on the Basis of BMI
Authors: Mathew Thomas Vinay , Chigarira Beverly , Gebrael Georges , Sayegh Nicolas , Tripathi Nishita , Nussenzveig Roberto , Jo Yeonjung , Dal Emre , Galarza Fortuna Gliceida , Li Haoran , Sahu Kamal Kant , Srivastava Ayana , Maughan Benjamin L. , Agarwal Neeraj , Swami Umang 
Published: May 2024

PURPOSE An increased BMI is linked to increased prostate adenocarcinoma incidence and mortality. Baseline tumor gene expression profiling (GEP) can provide a comprehensive picture of the biological processes related to treatment response and disease progression. We interrogate and validate the underlying differences in tumor GEP on the basis of BMI in patients with prostate adenocarcinoma. METHODS The inclusion criteria consisted of histologically confirmed prostate adenocarcinoma and the availability of RNA sequencing data obtained from treatment-naïve primary prostate tissue. RNA sequencing was performed by a Clinical Laboratory Improvement Amendments–certified laboratory (Tempus or Caris Life Sciences). The Tempus cohort was used for interrogation and the Caris cohort for validation. Patients were stratified on the basis of BMI at the time of prostate cancer diagnosis: BMI-high (BMIH; BMI ≥30) and BMI-low (BMIL; BMI <30). Differential gene expression analysis between the two cohorts was conducted using the DEseq2 pipeline. The resulting GEPs were further analyzed using Gene Set Enrichment software to identify pathways that exhibited enrichment in each cohort. RESULTS Overall, 102 patients were eligible, with 60 patients in the Tempus cohort (BMIL = 38, BMIH = 22) and 42 patients in the Caris cohort (BMIL = 24, BMIH = 18). Tumor tissues obtained from patients in the BMIL group exhibited higher expression of genes associated with inflammation pathways. BMIH displayed increased expression of genes involved in pathways such as heme metabolism and androgen response. CONCLUSION Our study shows the upregulation of distinct genomic pathways in BMIL compared with BMIH patients with prostate cancer. These hypothesis-generating data could explain different survival outcomes in both groups and guide personalized therapy for men with prostate cancer.
Germline Pathogenic Variants in Patients With Pancreatic and Periampullary Cancers
Authors: Ando Yohei , Dbouk Mohamad , Yoshida Takeichi , Abou Diwan Elizabeth , Saba Helena , Dbouk Ali , Yoshida Kanako , Roberts Nicholas J. , Klein Alison P. , Burkhart Richard , He Jin , Hruban Ralph H. , Goggins Michael 
Published: May 2024

PURPOSE Inherited cancer susceptibility is often not suspected in the absence of a significant cancer family history. Pathogenic germline variants in pancreatic cancer are well-studied, and routine genetic testing is recommended in the guidelines. However, data on rare periampullary cancers other than pancreatic cancer are insufficient. We compared the prevalence of germline susceptibility variants in patients with pancreatic cancer and nonpancreatic periampullary cancers. MATERIALS AND METHODS Six hundred and eight patients who had undergone pancreaticoduodenal resection at a tertiary referral hospital were studied, including 213 with pancreatic ductal adenocarcinoma, 172 with ampullary cancer, 154 with distal common bile duct cancer, and 69 with duodenal adenocarcinoma. Twenty cancer susceptibility and candidate susceptibility genes were sequenced, and variant interpretation was assessed by interrogating ClinVar and PubMed. RESULTS Pathogenic or likely pathogenic, moderate- to high-penetrant germline variants were identified in 46 patients (7.7%), including a similar percentage of patients with pancreatic (8.5%) and nonpancreatic periampullary cancer (7.1%). Low-penetrant variants were identified in an additional 11 patients (1.8%). Eighty-nine percent of the moderate- to high-penetrant variants involved the major cancer susceptibility genes BRCA2, ATM, BRCA1, CDKN2A, MSH2/ MLH1, and PALB2; the remaining 11% involved other cancer susceptibility genes such as BRIP1, BAP1, and MSH6. Almost all pathogenic variant carriers had a family history of cancer. CONCLUSION Patients with pancreatic and nonpancreatic periampullary cancer have a similar prevalence of pathogenic cancer susceptibility variants. Germline susceptibility testing should be considered for patients with any periampullary cancer.
Quantum steering in a star network
Authors: Jiang Guangming , Wu Xiaohua , Zhou Tao 
Published: May 2024

Abstract
In this work, we will consider the star network scenario where the central party is trusted while all the edge parties (with a number of n) are untrusted. Network steering is defined with an n local hidden state model which can be viewed as a special kind of n local hidden variable model. Two different types of sufficient criteria, nonlinear steering inequality and linear steering inequality will be constructed to verify the quantum steering in a star network. Based on the linear steering inequality, how to detect the network steering with a fixed measurement will be discussed.
Phenylbutyrate Treatment in a Boy With MCT8 Deficiency: Improvement of Thyroid Function Tests and Possible Hepatotoxicity
Authors: Schreiner Felix , Vollbach Heike , Sonntag Niklas , Schempp Vera , Gohlke Bettina , Friese Johannes , Woelfle Joachim , Braun Doreen , Schweizer Ulrich 
Published: May 2024

Abstract

Context
Monocarboxylate transporter 8 (MCT8) deficiency is a rare X-chromosomal inherited disease leading to severe cognitive impairment, muscular hypotonia, and symptoms of peripheral thyrotoxicosis. Experimental approaches aiming to functionally rescue mutant MCT8 activity by the chemical chaperone phenylbutyrate (PB) demonstrated promising effects in vitro for several MCT8 missense mutations.

Objective
The objective was to evaluate biochemical and clinical effects of PB in doses equivalent to those approved for the treatment of urea cycle disorders in a boy with MCT8 deficiency due to a novel MCT8 missense mutation c.703G&gt;T (p.V235L).

Results
During a treatment period of 13 months, PB led to a significant decrease of elevated thyrotropin and triiodothyronine (T3) serum concentrations, while free thyroxine (fT4) increased. The weight z-score of the toddler remained remarkably stable during the treatment period. Neurodevelopmental assessments (BSID-III) revealed a slight increase of gross motor skills from developmental age 4 to 6 months. However, increasing liver enzyme serum activities and accumulation of phenylacetate in urine led to treatment interruptions and dose alterations. In vitro analyses in MDCK1 cells confirmed the pathogenicity of MCT8 p.V235L. However, while PB increased expression of the mutant protein, it did not rescue T3 transport, suggesting a PB effect on thyroid function tests independent of restoring MCT8 activity.

Conclusion
In a clinical attempt of PB treatment in MCT8 deficiency we observed a significant improvement of thyroid hormone function tests, tendencies toward body weight stabilization and slight neurodevelopmental improvement. Hepatotoxicity of PB may be a limiting factor in MCT8 deficiency and requires further investigation.
Maternal Thyroid Function in Early Pregnancy and Offspring School Performance and Neurodevelopmental Disorders
Authors: Møllehave Line Tang , Grand Mia Klinten , Kriegbaum Margit , Andersen Christen Lykkegaard , Lind Bent Struer , van Vliet Nicolien Alien , van Heemst Diana , Strandberg-Larsen Katrine 
Published: May 2024

Abstract

Context
Thyroid hormones are critical for neural development, and during the first trimester of pregnancy, the fetus relies fully on maternal thyroid hormone production.

Objective
To investigate the associations between maternal thyroid hormone levels in the first trimester with the child's school performance, risk of attention deficit hyperactivity disorder (ADHD), and autism spectrum disorder (ASD).

Methods
Information from the Copenhagen Primary Care Laboratory Pregnancy Database on first trimester TSH and free thyroxine measurements in mothers of children born in 2000 through 2014 were linked with information on the child's standardized test scores in school, ADHD (patient record diagnoses and medication), and ASD (patient record diagnoses) until the end of 2018. Associations of TSH and free thyroxine with the outcomes were individually assessed by linear mixed models and Cox regression models. The analyses were stratified by preexisting maternal thyroid disorders.

Results
TSH measurements were available for 17 909 mother-child dyads. Among those with children born in 2000 through 2009, 6126 had a standardized school test score and were analyzed for the association between maternal thyroid hormone levels and child's school performance, and no support for an association was found. The association between thyroid hormone levels and child's risk of ADHD and ASD were analyzed for the 17 909 dyads and with no support for an association between thyroid hormone levels and these neurodevelopmental disorders. Stratification by preexisting maternal thyroid disorders did not affect the results.

Conclusion
We found no evidence for associations between first trimester maternal thyroid hormone levels and child's school performance, or risk of ADHD or ASD.
Troubling Decriminalization
Authors: Scott John , Scoular Jane 
Published: May 2024

Abstract
In the context of a fiercely polarized battle on the correct legal response to prostitution, sex workers and their advocates often advance decriminalization as a policy that can protect rights and provide improved health and safety for those involved in the sex industry. And yet this policy, after an initial implementation in New South Wales in 1995, has failed to gain much legislative support in jurisdictions outside Australia and New Zealand. This article moves beyond normative arguments regarding the benefits and limits of decriminalization. Drawing on governmentality approaches, it asks: What discursive conditions made decriminalization possible? In doing so it examines the construction of sex work as a health problem and the normalization of “sex work,” arguing that both can be grounded in a neoliberal problematic of governance.
A methodological approach for collecting simultaneous measures of muscle, aponeurosis, and tendon behaviour during dynamic contractions
Authors: Ross Stephanie A. , Waters-Banker Christine , Sawatsky Andrew , Leonard Timothy R. , Herzog Walter 
Published: May 2024

ABSTRACT
Skeletal muscles and the tendons that attach them to bone are structurally complex and deform non-uniformly during contraction. While these tissue deformations dictate force production during movement, our understanding of this behaviour is limited due to challenges in obtaining complete measures of the constituent structures. To address these challenges, we present an approach for simultaneously measuring muscle, fascicle, aponeurosis, and tendon behaviour using sonomicrometry. To evaluate this methodology, we conducted isometric and dynamic contractions in in situ rabbit medial gastrocnemius. We found comparable patterns of strain in the muscle belly, fascicle, aponeurosis, and tendon during the isometric trials to those published in the literature. For the dynamic contractions, we found that our measures using this method were consistent across all animals and aligned well with our theoretical understanding of muscle-tendon unit behaviour. Thus, this method provides a means to fully capture the complex behaviour of muscle-tendon units across contraction types.
A mathematical framework for measuring and tuning tempo in developmental gene regulatory networks
Authors: Manser Charlotte L. , Perez-Carrasco Ruben 
Published: May 2024

ABSTRACT
Embryo development is a dynamic process governed by the regulation of timing and sequences of gene expression, which control the proper growth of the organism. Although many genetic programmes coordinating these sequences are common across species, the timescales of gene expression can vary significantly among different organisms. Currently, substantial experimental efforts are focused on identifying molecular mechanisms that control these temporal aspects. In contrast, the capacity of established mathematical models to incorporate tempo control while maintaining the same dynamical landscape remains less understood. Here, we address this gap by developing a mathematical framework that links the functionality of developmental programmes to the corresponding gene expression orbits (or landscapes). This unlocks the ability to find tempo differences as perturbations in the dynamical system that preserve its orbits. We demonstrate that this framework allows for the prediction of molecular mechanisms governing tempo, through both numerical and analytical methods. Our exploration includes two case studies: a generic network featuring coupled production and degradation, with a particular application to neural progenitor differentiation; and the repressilator. In the latter, we illustrate how altering the dimerisation rates of transcription factors can decouple the tempo from the shape of the resulting orbits. We conclude by highlighting how the identification of orthogonal molecular mechanisms for tempo control can inform the design of circuits with specific orbits and tempos.
Clinical Frailty Scale - frailty assessment and rehabilitation potential
Authors: Wiśniewski Szymon , Hołownia Weronika , Krzesłowska Wiktoria Julia , Pytel Paulina , Szewczyk Kamila , Szewczyk Bartłomiej 
Published: May 2024

Background: Studies show a significant increase in frailty prevalence among older adults worldwide. Fortunately, several well-established and user-friendly screening tools can effectively identify frailty in older adults.
Objectives: This article examines the Clinical Frailty Scale's effectiveness in informing treatment decisions for older adults in ambulatory care settings, analyzing its potential to improve patient care.
Methods: On April 1, 2024, the PubMed database was searched for articles on the Clinical Frailty Scale in elderly patients. The 116 most pertinent and current articles, written in English and published within the past few years, were analyzed, and 38 were selected and categorized by content and topic.

Limitations: This study is limited because it is not a meta-analysis and thus does not examine the quality of the evidence presented in each article.
Conclusions: Frailty research has illuminated aging and its potential biological causes. The Clinical Frailty Scale effectively identifies vulnerable individuals. By using the CFS to assess frailty risk, healthcare providers can personalize treatment plans and improve overall care for older adults.
Adaptive, Doubly Optimal No-Regret Learning in Strongly Monotone and Exp-Concave Games with Gradient Feedback
Authors: Jordan Michael , Lin Tianyi , Zhou Zhengyuan 
Published: May 2024

Feasible Online Learning with Gradient Feedback Online gradient descent (OGD) is well-known to be doubly optimal under strong convexity or monotonicity assumptions: (1) in the single-agent setting, it achieves an optimal regret of [Formula: see text] for strongly convex cost functions, and (2) in the multiagent setting of strongly monotone games with each agent employing OGD we obtain last-iterate convergence of the joint action to a unique Nash equilibrium at an optimal rate of [Formula: see text]. Whereas these finite-time guarantees highlight its merits, OGD has the drawback that it requires knowing the strong convexity/monotonicity parameters. In “Adaptive, Doubly Optimal No-Regret Learning in Strongly Monotone and Exp-Concave Games with Gradient Feedback,” M. Jordan, T. Lin, and Z. Zhou design a fully adaptive OGD algorithm, AdaOGD, that does not require a priori knowledge of these parameters. In the single-agent setting, the algorithm achieves [Formula: see text] regret under strong convexity, which is optimal up to a log factor. Further, if each agent employs AdaOGD in strongly monotone games, the joint action converges in a last-iterate sense to a unique Nash equilibrium at a rate of [Formula: see text], again optimal up to log factors. The algorithms are illustrated in a learning version of the classic newsvendor problem, in which, because of lost sales, only (noisy) gradient feedback can be observed. The results immediately yield the first feasible and near-optimal algorithm for both the single-retailer and multiretailer settings.
Oxford Spine Buddies: an acceptability and feasibility project for peer-to-peer support in a spine sarcoma service
Authors: Cammas Jasmine , Tomy Sheto , Strickland Louise , Mawhinney Gerard 
Published: May 2024

Background: Primary bone and soft tissue sarcoma of the spine are rare and account for less than 0.2% of all neoplasm incidences. Following a patient and public involvement event, the need to explore patient support pathways was identified, which initiated this service evaluation project. Aim: To determine the acceptability and feasibility of a peer-to-peer support project among people using the spine sarcoma service. Methods: Users were paired and introduced via Microsoft Teams. Quantitative and qualitative data both pre- and post-introduction of a buddy were collected. Findings: Service users felt that, although they would have preferred having a buddy at the time of their diagnosis, being allocated a buddy made them feel reassured and better supported. Conclusion: The project was well received and preliminary data are encouraging. Therefore, due to early findings from the first participants, the service is continuing to roll out the buddy programme.
Restoration of normal central pain processing following manual therapy in nonspecific chronic neck pain
Authors: Mata Josu Zabala , Azkue Jon Jatsu , Bialosky Joel E. , Saez Marc , López Estíbaliz Dominguez , Arrieta Maialen Araolaza , Lascurain-Aguirrebeña Ion 
Published: May 2024

Objective
To determine if a 4-week manual therapy treatment restores normal functioning of central pain processing mechanisms in non-specific chronic neck pain (NSCNP), as well as the existence of a possible relationship between changes in pain processing mechanisms and clinical outcome.

Design
Cohort study.

Methods
Sixty-three patients with NSCNP, comprising 79% female, with a mean age of 45.8 years (standard deviation: 14.3), received four treatment sessions (once a week) of manual therapy including articular passive mobilizations, soft tissue mobilization and trigger point treatment. Pressure pain thresholds (PPTs), conditioned pain modulation (CPM) and temporal summation of pain (TSP) were evaluated at baseline and after treatment completion. Therapy outcome was measured using the Global Rating of Change Scale (GROC), the Neck disability Index (NDI), intensity of pain during the last 24 hours, Tampa Scale of Kinesiophobia (TSK) and Pain Catastrophizing Scale (PCS). Two sets of generalized linear mixed models with Gaussian response and the identity link were employed to evaluate the effect of the intervention on clinical, psychological and psychophysical measures and the association between psychophysical and clinical outcomes.

Results
Following treatment, an increased CPM response (Coefficient: 0.89; 95% credibility interval = 0.14 to 1.65; P = .99) and attenuated TSP (Coefficient: -0.63; 95% credibility interval = -0.82 to -0.43; P = 1.00) were found, along with amelioration of pain and improved clinical status. PPTs at trapezius muscle on the side of neck pain were increased after therapy (Coefficient: 0.22; 95% credibility interval = 0.03 to 0.42; P = .98), but not those on the contralateral trapezius and tibialis anterior muscles. Only minor associations were found between normalization of TSP/CPM and measures of clinical outcome.

Conclusion
Clinical improvement after manual therapy is accompanied by restoration of CPM and TSP responses to normal levels in NSCNP patients. The existence of only minor associations between changes in central pain processing and clinical outcome suggests multiple mechanisms of action of manual therapy in NSCNP.
The association between urinary incontinence and suicidal ideation: Findings from the National Health and Nutrition Examination Survey
Authors: Pan Ting , Zhang Zhiguo , He Tiantian , Zhang Chongyang , Liang Junjie , Wang Xinru , Di Xueshi , Hong Yuying , Bai Peng 
Published: May 2024

Background
Urinary incontinence (UI) might be linked to suicidal ideation, but we do not yet have all the relevant details. This study aimed to dig deeper into the connection between UI and suicidal ideation using data from the National Health and Nutrition Examination Survey (NHANES).

Methods
We examined 31,891 participants aged ≥ 20 years from NHANES 2005–2018 who provided complete information. We used standardized surveys to check for UI and signs of suicidal ideation. To better understand this relationship, we used statistical tools such as multivariable logistic regression, subgroup analysis, and sensitivity analyses.

Results
Among the 31,891 participants, 28.9% reported UI and 10.7% reported suicidal ideation. Those with UI exhibited a significantly greater incidence of suicidal ideation (15.5%) than did those without UI (8.8%, P < 0.001). After adjusting for various factors, including age, sex, marital status, socioeconomic status, educational level, lifestyle factors, and chronic comorbidities, UI remained significantly associated with suicidal ideation (OR:1.54, 95% CI = 1.39–1.7, P < 0.001). Among all types of UI, MUI participants were more likely to experience suicidal ideation. Compared with no UI, higher odds of suicidal ideation suffered from MUI (OR:2.11, 95%CI:1.83–2.44, P < 0.001), SUI (OR:1.4, 95%CI:1.19–1.65, P < 0.001), UUI(OR:1.37,95%CI:1.16–1.62, P < 0.001) after full adjustment. With the exception of individuals living with a partner, the remaining subgroups exhibited a positive correlation between urinary incontinence and suicidal ideation, considering that factors such as age, sex, and prevalent comorbidities such as hypertension, depression, and diabetes did not reveal any statistically significant interactions (all P > 0.05). Sensitivity analyses, incorporating imputed missing covariates, did not substantially alter the results (OR: 1.53, 95% CI: 1.4–1.68, P < 0.001).

Conclusion
Urinary incontinence may correlate with increased suicidal ideation risk, priority screening for suicidal ideation and timely intervention are essential for individuals with urinary incontinence, but prospective studies are needed to verify the results.