bluuebunny/crossref_metadata_2025_split huggingface dataset:
Fully automated reconstruction of ungated ghost magnetic resonance angiograms
Authors: Tsaftaris Sotirios A. , Offerman Erik , Edelman Robert R. , Koktzoglou Ioannis 
Published: February 2010

AbstractPurpose:To completely automate the reconstruction process during noncardiac‐gated unenhanced ghost magnetic resonance angiography (MRA).Materials and Methods:Ungated unenhanced ghost MRA of the calf was performed in 16 volunteers. K‐means and fuzzy c‐means (FCM) clustering algorithms using prominent image features were applied to automatically create angiograms of the calf in volunteers undergoing ungated ghost MRA. Ghost angiograms reconstructed automatically were compared to those created manually on the basis of diagnostic image quality and apparent arterial‐to‐background contrast‐to‐noise ratio (CNR). Images were also ranked by an expert user in their order of preference using an ordinal scale.Results:Compared with the ghost angiograms created manually, ghost angiograms reconstructed automatically with the use of clustering analysis provided similar arterial‐to‐background CNR values. No differences in diagnostic quality or preference were identified between images reconstructed manually and automatically.Conclusion:We present fully automated image reconstruction algorithms for use with ungated and unenhanced ghost MRA. These automated algorithms, based on the use of k‐means or FCM clustering, can be used to eliminate manual postprocessing that is time‐consuming and subject to variability. J. Magn. Reson. Imaging 2010;31:655–662. © 2010 Wiley‐Liss, Inc.
Delayed gadolinium‐enhanced MRI of cartilage in the ankle at 3 T: Feasibility and preliminary results after matrix‐associated autologous chondrocyte implantation
Authors: Domayer Stephan E. , Trattnig Siegfried , Stelzeneder David , Hirschfeld Clemens , Quirbach Sebastian , Dorotka Ronald , Nehrer Stefan , Pinker Katja , Chan Jenny , Mamisch Tallal Charles , Dominkus Martin , Welsch Götz H. 
Published: February 2010

AbstractPurpose:To demonstrate the feasibility of delayed gadolinium‐enhanced magnetic resonance imaging (MRI) of cartilage (dGEMRIC) in the ankle at 3 T and to obtain preliminary data on matrix associated autologous chondrocyte (MACI) repair tissue.Materials and Methods:A 3D dual flip angle sequence was used with an eight‐channel multipurpose coil at 3 T to obtain T1 maps both pre‐ and postintravenous contrast agent (Magnevist, 0.2 mM/kg). Postcontrast T1 over time was evaluated in three volunteers; a modified dGEMRIC protocol was then used to assess 10 cases after MACI in the ankle.Results:Forty‐five minutes were found sufficient for maximum T1 decrease. MACI cases had a precontrast mean T1 of 1050 ± 148.4 msec in reference cartilage (RC) and 1080 ± 165.6 msec in repair tissue (RT). Postcontrast T1 decreased to 590 ± 134.0 msec in RC and 554 ± 133.0 msec in RT. There was no significant difference between the delta relaxation rates in RT (9.44 × 10−4 s−1) and RC (8.04 × 10−4 s−1, P = 0.487). The mean relative delta relaxation rate was 1.34 ± 0.83.Conclusion:It is feasible to assess the thin cartilage layers of the ankle with dGEMRIC at 3 T; MACI can yield RT with properties similar to articular cartilage. J. Magn. Reson. Imaging 2010;31:732–739. © 2010 Wiley‐Liss, Inc.
Time‐resolved lower extremity MRA with temporal interpolation and stochastic spiral trajectories: Preliminary clinical experience
Authors: Lim Ruth P. , Jacob Jason S. , Hecht Elizabeth M. , Kim Danny C. , Huffman Steven D. , Kim Sooah , Babb James S. , Laub Gerhard , Adelman Mark A. , Lee Vivian S. 
Published: February 2010

AbstractPurpose:To assess added value of a new time‐resolved technique with temporal interpolation and stochastic spiral trajectory through k‐space and parallel imaging (TR‐MRA) to conventional bolus chase MRA (BC‐MRA) for infragenual peripheral artery evaluation.Materials and Methods:An institutional review board‐approved retrospective review of peripheral arterial disease patients was performed. Infragenual TR‐MRA and BC‐MRA were performed in 26 patients over four months. Two readers individually assessed image quality, diagnostic confidence, and stenosis severity and length in 13 defined below knee segments, first with BC‐MRA alone, and then with a combined BC‐MRA and TR‐MRA reading (BC+TR‐MRA). Perceived contribution of TR‐MRA was rated by each reader. The reference standard was a consensus reading of both sequences. Catheter angiographic (CA) correlation was available in 6 patients.Results:A total of 646 infragenual segments in 51 extremities were evaluated. Image quality and diagnostic confidence were superior for BC+TR‐MRA compared with BC‐MRA alone (P < 0.001). Adding TR‐MRA improved sensitivity (85.7% versus 80.7%; P < 0.05) and diagnostic accuracy (88.1% versus 85.4%; P < 0.05) for hemodynamically significant stenosis. Venous contamination (0% versus 13.1% segments) and motion (0.9% versus 8.0%) were decreased for BC+TR‐MRA versus BC‐MRA alone, P < 0.01. For BC+TR‐MRA, TR‐MRA was rated more useful than BC‐MRA in 30/51 legs (58.8%). TR‐MRA identified retrograde flow in 5 segments. Where available, there was high concordance between CA and BC+TR‐MRA (91.6%) for stenosis.Conclusion:Adding TR‐MRA with temporal interpolation and stochastic spiral trajectories to bolus chase MRA improves image quality, diagnostic confidence and accuracy. It provides hemodynamic information and minimizes venous contamination and patient motion. J. Magn. Reson. Imaging 2010;31:663–672. © 2010 Wiley‐Liss, Inc.
Intraoperative magnetic resonance imaging in the surgical treatment of cerebral metastases
Authors: Senft Christian , Ulrich Christian T. , Seifert Volker , Gasser Thomas 
Published: February 2010

AbstractBackground and ObjectivesTo report on the value of intraoperative magnetic resonance imaging (iMRI) in the neurosurgical treatment of cerebral metastases (CM).MethodsWe performed a total of 204 surgical procedures with the use of a mobile ultra‐low‐field iMRI‐unit. Of these, there were 12 craniotomies and 2 minimal‐invasive procedures for CM, and 63 craniotomies for glioblastoma (GBM).ResultsOn intraoperative imaging, all tumors could be localized and targeted with the help of the integrated neuronavigation system. Intraoperative imaging resulted in continued tumor resection due to unexpected residual tumor tissue in 13 patients harboring GBM (20.6%), but no patient with a CM (0%). In two patients with cystic CM, iMRI helped to achieve complete collapse of cysts by means of stereotactic aspiration, relieving mass effect and allowing for adjuvant radiotherapy. All patients subsequently received adjuvant treatment according to clinical protocols.ConclusionSurgical resection represents one of several treatment modalities in metastatic brain disease. iMRI is useful for neuronavigation and resection control and as an adjunct in minimal‐invasive procedures in patients with CM; however, its exact value is yet to be determined by prospective randomized trials. J. Surg. Oncol. 2010; 101:436–441. © 2010 Wiley‐Liss, Inc.
Intra‐operative contrast‐enhanced ultrasound improves image enhancement in the evaluation of liver tumors
Authors: Martin Robert C.G. , Reuter Nathan P. , Woodall Charles 
Published: February 2010

AbstractBackgroundIntra‐operative hepatic tumor ultrasound assessment can be difficult in patients with abnormal hepatic parenchyma because of the inability to enhance echogenic differences.MethodsProspective pilot study of intra‐operative ultrasound contrast enhancement in the evaluation of liver tumors to establish safety, dosing, and increased image enhancement with ultrasound contrast evaluation. A single bolus of perfluten lipid microspheres was then injected and ultrasound images were then re‐recorded and saved.ResultsTwenty consecutive patients underwent contrast‐enhanced ultrasound evaluation during the operative procedure. All patients received at least one bolus dose of microspheres (median 2 dose, range 1–3), without change in heart rate, blood pressure, end tidal CO2, oxygen saturation, and sedation monitoring at the time of dosing and until 4 hr post‐bolus doses. Two blinded independent readers found the contrasted images to have a statistically greater degree of enhancement (median improvement of 4, P = 0.01) and greater degree of size/border characteristics in the contrasted images (median improvement of 5, P = 0.01) for all histologies. In five patients, the extent of hepatic resection was altered from partial to complete lobectomy in order to obtain acceptable oncologic margin.ConclusionsContrast‐enhanced ultrasound is safe and effective in pre‐resection and pre‐ablation treatment planning. J. Surg. Oncol. 2010; 101:370–375. © 2010 Wiley‐Liss, Inc.
Selecting treatment for hepatocellular carcinoma based on the results of hepatic resection and local ablation therapy
Authors: Nanashima Atsushi , Tobinaga Syuuichi , Masuda Junichi , Miyaaki Hisamitsu , Taura Naota , Takeshita Hiroaki , Hidaka Shigekazu , Sawai Terumitsu , Nakao Kazuhiko , Nagayasu Takeshi 
Published: February 2010

AbstractBackgroundFirst‐line treatment for ≤3 hepatocellular carcinomas (HCCs) ≤3 cm in size remains controversial. The superiority of survival benefit needs to be clarified between these modalities for such lesions.MethodsWe examined post‐treatment survival of 144 consecutive HCC patients who underwent hepatectomy and of 56 consecutive HCC patients who underwent thermal ablation therapy limited to the HCC (≤3 cm, ≤3 lesions).ResultsPretreatment liver function was significantly worse and prevalence of Child‐Pugh classification B/C was significantly higher in the ablation group compared to the hepatectomy group. Prevalence of tumor recurrence after treatment did not differ significantly between groups, irrespective of solitary or multiple HCC. In solitary HCC, overall survival rates in both groups did not differ significantly. Even in Child‐Pugh B patients, survival was not significantly different between hepatectomy and ablation. In HCC with 2–3 lesions ≤3 cm, overall survival was significantly longer with hepatectomy than with ablation and mean survival periods in the hepatectomy and ablation groups were 4.5 and 1.2 years, respectively.ConclusionIn cases of multiple small HCCs, hepatic resection is recommended over local ablation therapy as the first‐line treatment in cases where liver function has been preserved. J. Surg. Oncol. 2010; 101:481–485. © 2010 Wiley‐Liss, Inc.
DNA Polyplexes Formed Using PEGylated Biodegradable Hyperbranched Polymers
Authors: Tao Lei , Chou William C. , Tan Beng H. , Davis Thomas P. 
Published: February 2010

AbstractA novel PEGylated biodegradable hyperbranched PEG‐b‐PDMAEMA has been synthesized. The low toxicity, small molecular weight PDMAEMA chains were crosslinked using a biodegradable disulfide‐based dimethacrylate (DSDMA) agent to yield higher molecular weight hyperbranched polymers. PEG chains were linked onto the polymer surface, masking the positive charge (as shown by Zeta potential measurements) and reducing the toxicity of the polymer. The hyperbranched structures were also cleaved under reducing conditions and analyzed, confirming the expected component structures. The hyperbranched polymer was mixed with DNA and efficient binding was shown to occur through electrostatic interactions. The hyperbranched structures could be reduced easily, generating lower toxicity oligomer chains.magnified image
Orientation Control of Photo‐Immobilized Antibodies on the Surface of Azobenzene‐Containing Polymers by the Introduction of Functional Groups
Authors: Mouri Makoto , Ikawa Taiji , Narita Mamiko , Hoshino Fumihiko , Watanabe Osamu 
Published: February 2010

AbstractIn our photo‐induced immobilization technique for an antibody (IgG) using azopolymers, the introduction of COOH and NMe2 into the azopolymers, which can introduce surface charges, strongly affected the immobilization properties such as the efficiency of immobilization and the activity of the immobilized IgG (i.e., the orientation of the immobilized IgG). The introduction of COOH promoted a more active orientation of the immobilized IgG. The orientation was determined during the adsorption process onto the azopolymer surface in solution before photo‐immobilization, and was maintained during the photo‐immobilization. The surface charge of the azopolymer appears to be an important factor for IgG orientation, which involves electrostatic interactions between its Fab and the azopolymer surface.magnified image
Asymptotic behavior of eigenvalues of Schrödinger type operators with degenerate kinetic energy
Authors: Hainzl Christian , Seiringer Robert 
Published: February 2010

AbstractWe study the eigenvalues of Schrödinger type operators T + λV and their asymptotic behavior in the small coupling limit λ → 0, in the case where the symbol of the kinetic energy, T (p), strongly degenerates on a non‐trivial manifold of codimension one (© 2010 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Radial solutions for Neumann problems involving mean curvature operators in Euclidean and Minkowski spaces
Authors: Bereanu Cristian , Jebelean Petru , Mawhin Jean 
Published: February 2010

AbstractIn this paper we study the existence of radial solutions for Neumann problems in a ball and in an annular domain, associated to mean curvature operators in Euclidean and Minkowski spaces. Our approach relies on the Leray‐Schauder degree together with some fixed point reformulations of our nonlinear Neumann boundary value problems (© 2010 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Boundary interpolation and rigidity for generalized Nevanlinna functions
Authors: Alpay Daniel , Dijksma Aad , Langer Heinz , Reich Simeon , Shoikhet David 
Published: February 2010

AbstractWe solve a boundary interpolation problem at a real point for generalized Nevanlinna functions, and use the result to prove uniqueness theorems for generalized Nevanlinna functions (© 2010 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
A Predictive Coarse‐Grained Model for Semiflexible Polymers in Specific Solvents
Authors: Shie Sheng C. , Lee Cheng K. , Hua Chi C. , Chen Show A. 
Published: February 2010

AbstractA predictive CG model based on a conventional freely rotating chain was developed to describe semiflexible polymers on a relatively large length/time scale. Parameterization of the model requires only two material properties such as, the Kuhn length and coil density. The diameter of spherical “beads” employed in the model is used as an effective parameter that needs to be determined from preliminary data. Once determined for a particular solvent system, this parameter can then be used to model general solvent systems on a parameter‐free basis. Comparison with SANS data on dilute conjugated polymer solutions reveals that the CG polymer model can well describe material properties ranging from local rodlike segments to bulk interchain aggregates.magnified image
The neural cell adhesion molecule is involved in the metastatic capacity in a murine model of lung cancer
Authors: Campodónico Paola B. , de Kier Joffé Elisa D. Bal , Urtreger Alejandro J. , Lauria Lilia S. , Lastiri José M. , Puricelli Lydia I. , Todaro Laura B. 
Published: February 2010

AbstractNeural cell adhesion molecule (NCAM) is involved in cell growth, migration, and differentiation. Its expression and/or polysialylation appear to be deregulated in many different cancer types. We employed the lung tumor cell line LP07, syngeneic in BALB/c mice to investigate the role of NCAM in malignant progression. LP07 cells express the three main NCAM isoforms, all of them polysialylated. This cells line, pretreated with an anti‐NCAM antibody and inoculated intravenously (i.v.) into syngeneic mice, developed less and smaller lung metastases. In vitro studies showed that NCAM bound antibody inhibited cell growth, mainly due to an increase in apoptosis, associated with a decrease of cyclin D1 and enhanced expression of active caspase 3 and caspase 9. Anti‐NCAM‐treated LP07 cells showed impairment in their ability to migrate and adhere to several extracellular matrix components. Secreted uPA activity was also reduced. NCAM‐140 knocked‐down by siRNA in LP07 cells pretreated or not with anti‐NCAM showed an impaired metastasizing ability upon i.v. inoculation into mice. These results suggest that anti‐NCAM treatment could be mimicking homophilic trans‐interactions and NCAM‐140 knocked‐down impairs heterophilic interactions, both leading to inhibition of metastatic dissemination. The involvement of NCAM in lung tumor progression was confirmed in human NSCLC tumors. Sixty percent of the cases expressed NCAM at tumor cell level. A multivariate analysis indicated that NCAM expression was associated with a shorter overall survival in this homogeneous series of Stages I and II NSCLC patients. NCAM may be able to modulate mechanisms involved in lung carcinoma progression and represents an attractive target to control metastatic progression. Mol. Carcinog. © 2010 Wiley‐Liss, Inc.
Goal Programming: realistic targets for the near future
Authors: Caballero Rafael , Gómez Trinidad , Ruiz Francisco 
Published: February 2010

AbstractGoal Programming (GP) can be regarded as one of the most widely used multicriteria decision‐making techniques. In this paper, two surveys are carried out. First, the evolution of GP since its birth to the present time, in terms of number of publications, references, journals, etc., has been studied. Second, a more in‐depth survey has been carried out, which covers the publications from year 2000 to the present time. All the references are listed, and some conclusions and future research lines have been extracted about the late trends of GP. Copyright © 2010 John Wiley & Sons, Ltd.
Protein degradation, aggregation, and misfolding
Authors: Cuervo Ana Maria , Wong Esther S.P. , Martinez‐Vicente Marta 
Published: February 2010

AbstractThe cellular surveillance systems guarantee proper removal of altered components from inside cells. Alterations of these systems in neurons have been proposed to be involved in the pathogenesis of different neurodegenerative disorders. In this review, we comment on the advances in our current understanding of how changes in the intracellular proteolytic systems, the main components of the cellular quality control system, contribute to neurodegeneration, with special emphasis on Parkinson's disease. © 2010 Movement Disorder Society
Clinical implications of gene discovery in Parkinson's disease and parkinsonism
Authors: Wider Christian , Foroud Tatiana , Wszolek Zbigniew K. 
Published: February 2010

AbstractOver the past decade, major progress has been achieved in the identification of genes associated with Parkinson's disease (PD) and parkinsonism. Five genes have now been shown conclusively to play a role in PD susceptibility. Mutations in three of these genes, PRKN, PINK1, and DJ1, are important in early onset, recessively inherited PD, while mutations in LRRK2 and SNCA result in autosomal‐dominant PD. LRRK2 has emerged as the most prevalent genetic cause of PD and has been implicated in both familial and sporadic forms of disease. In addition, autosomal‐dominant dementia and Parkinsonism has been shown to be caused by mutations in the MAPT and PGRN genes. Molecular tests are now commercially available for several of these genes; however, in some of them, positive results need to be interpreted with caution until penetrance is better understood. In addition, clinical treatment of PD remains largely unaltered by the results of genetic testing. © 2010 Movement Disorder Society
Evaluation of the Braak staging scheme for Parkinson's disease: Introduction to a panel presentation
Authors: Burke Robert E. 
Published: February 2010

AbstractBraak and colleagues have proposed a staging scheme for Parkinson's disease (PD) based on patterns of abnormal immunostaining for α‐synuclein. They have proposed a temporal sequence in which the appearance of Lewy bodies and neurites in brainstem structures represent the earliest manifestations of the disease, and that this involvement of non‐dopaminergic structures long antedates involvement of the substantia nigra and the appearance of the cardinal motor signs that are now required for diagnosis. This proposed scheme has had a wide and profound impact on many aspects of current thinking about PD, and it has already received wide acceptance. Given the importance and growing acceptance of the Braak staging scheme, the Scientific Program Committee for this Educational Symposium to honor the 50th Anniversary of the Parkinson's Disease Foundation agreed that it would be highly worthwhile to devote an entire session of the Scientific Program to consideration of the Braak staging scheme. There was a consensus among members of the Committee that, given the importance of the Braak scheme, it would be of value to create a venue that would stimulate and encourage a thorough and incisive critical analysis. © 2010 Movement Disorder Society
Sleep disturbances in Parkinson's disease
Authors: Menza Matthew , Dobkin Roseanne DeFronzo , Marin Humberto , Bienfait Karina 
Published: February 2010

AbstractSleep disturbances are very common in patients with PD and are associated with a variety of negative outcomes. The evaluation of sleep disturbances in these patients is complex, as sleep may be affected by a host of primary sleep disorders, other primary medical or psychiatric conditions, reactions to medications, aging or the neuropathophysiology of PD itself. In this article, we review the evaluation of the common disturbances of sleep seen in PD. This includes the primary sleep disorders, the interaction of depression and insomnia, the impact that medications for PD have on sleep, as well as the role of factors such as nocturia, pain, dystonia, akinesia, difficulty turning in bed, and vivid dreaming. The treatment of sleep disturbances in PD is largely unstudied but recommendations based on clinical experience in PD and research studies in other geriatric populations can be made. Important principles include, diagnosis, treating the specific sleep disorder or co‐occurring disorder, and control of the motor aspects of PD. © 2010 Movement Disorder Society
Assessment of regional variation in polypharmacy
Authors: Hovstadius Bo , Åstrand Bengt , Petersson Göran 
Published: February 2010

AbstractPurposeTo assess polypharmacy in a population with emphasis on regions.MethodsWe studied the individual‐based data of all dispensed prescription drugs (DP) during a 3‐month study period in Sweden 2006. As an indicator of polypharmacy, five or more (DP ≥ 5) different drugs (substances) dispensed were applied. For analysis, we used comparisons of prevalence, correlation of prevalence of polypharmacy with different socioeconomic variables, and a novel weighted polypharmacy index.ResultsThe national prevalence of polypharmacy, DP ≥ 5, was 10.5% (inter‐regional variation 9.1–12.1%). The regional variation in the prevalence of polypharmacy was largest for the age groups ≥90 (45.6–59.1%), 80–89 (46.1–53.4%) and 70–79 years (33.1–38.0%). The national prevalence of excessive polypharmacy, DP ≥ 10, was 2.2% (inter‐regional variation 1.9–2.6%). The regional variation in prevalence of excessive polypharmacy was largest for the age groups ≥90 (9.8–22.3%), 80–89 (11.4–17.1%) and 70–79 years (7.0–9.4%). We found a fairly strong positive correlation between polypharmacy and the age group ≥70 years (r = 0.84 for men and 0.71 for women). The novel weighted polypharmacy index indicated regional differences in the internal distribution of the prevalence of dispensed drugs for individuals with polypharmacy.ConclusionOur findings indicate that the observed regional differences in the prevalence of polypharmacy partly can be explained by the regional age distribution in Sweden. The use of the novel weighted polypharmacy index indicated regional differences in drug therapy for individuals with polypharmacy. Copyright © 2010 John Wiley & Sons, Ltd.