bluuebunny/crossref_metadata_2025_split huggingface dataset:
Electrochemical Performance of LiV3O8−xClxCathode Materials Synthesized by a Low‐Temperature Solid State Method
Authors: LIU Li , JIAO Lifang , SUN Junli , LIU Sichen , YUAN Huatang , WANG Yongmei 
Published: June 2009

AbstractA series of cathode materials for lithium ion batteries with the formula LiV3O8−xClx (x=0.00, 0.05, 0.10 and 0.15) were synthesized by a low‐temperature solid‐state method. The effects of Cl− substitution on the structure, morphology and electrochemical properties of the cathode materials were investigated through X‐ray diffraction (XRD), scanning electron microscopy (SEM), charge‐discharge test, cyclic voltammetry (CV) and electrochemical impedance spectroscopy (EIS) experiments. The results show that an enhanced cycle performance is on the Cl− doped cathode materials. LiV3O7.90Cl0.10 shows the best electrochemical performances with the discharge capacity remaining 198.6 mAh/g after 100 cycles, which results from a greater reversibility during cycling and decrease of particle‐to‐particle impedance.
Effects of Surface Modification on the Dispersion Property of VGC
Authors: FU Yaqin , HAN Chunshao , NI Qingqing 
Published: June 2009

AbstractIn view of the easy agglomeration issue of vapor grown carbon fiber (VGCF) and the poor interfacial adhesion between VGCF and matrix resin, two‐step surface modification with hydrogen peroxide and concentrated nitric acid was performed on VGCF. The surface structure and dispersion of VGCF before and after modification were tested and analyzed by XRD, TGA, FTIR, UV‐visible spectrum and SEM. Moreover, VGCF/SMPU composites were prepared via a solution mixing method taking shape memory polyurethane (SMPU) as matrix, and the mechanical properties of the composites were also tested. The graphite crystal structure of VGCF showed very little change after modification, the concentration of oxygen‐containing functional groups on the surface of VGCF was visibly increased, and the dispersion and dispersion stability of VGCF in organic solvent were also clearly improved. In the cross section of the VGCF/SMPU composites, the dispersion of VGCF in matrix and the VGCF‐matrix interfacial adhesion observed through SEM were both enhanced to a certain extent after surface modification. The two‐step surface modified VGCF had more obvious mechanical reinforcement effects on the composites than that of the pristine VGCF.
Enhanced Binding of a Non‐hydrogen Bond Ligand to DNA by Introducing an Apurine/Apyrimidine Site
Authors: SHAO Yong , NIU Zhenjiang , CHEN Jianrong , ZHANG Liangke 
Published: June 2009

AbstractIntercalators are well known for their DNA binding specificity by inserting between base pairs, whereas the binding event occurring to apurine/apyrimidine site (AP site)‐containing DNA for this type of noncovalent interaction is still not highlighted although AP site is frequently in vivo produced in living cells. Here proflavine (PF) as an example is used to investigate the binding specificity of the AP site in DNA for a non‐hydrogen bond ligand. Experimental results indicate that the AP site should be the preferential binding site for PF. The intrinsic binding constant of PF for the AP site is one order of magnitude greater than that occurring for PF intercalation. Additionally, the thermostability of the AP site‐containing DNA is significantly increased after PF binding. The PF bound to the AP site should adopt a specific binding orientation distinguishable from that by which PF intercalated into base pairs. The results obtained here should be very useful for judging biochemical and biophysical effectiveness of small molecules based on their different binding behavior to DNA.
One‐pot Three‐component Synthesis of 3,4‐Dihydroquinazolin‐4‐one Derivatives under Aqueous Medium or Solvent‐free Conditions
Authors: BANDGAR Babasaheb P. , MORE Parmeshwar. E. , KAMBLE Vinod T. 
Published: June 2009

Abstract3,4‐Dihydroquinazolin‐4‐one derivatives were synthesized in moderate to high yields by one‐pot condensation of anthranilic acid, amines, and formic acid or orthoester without catalyst under aqueous medium or solvent‐free conditions.
An Efficient Microwave‐assisted Synthesis of Pyrido[2,3‐d]pyrimidine Derivatives
Authors: TU Shujiang , WU Shanshan , HAN Zhengguo , HAO Wenjuan 
Published: June 2009

AbstractA series of new pyrido[2,3‐d]pyrimidine derivatives were synthesized by multi‐component reactions of equimolar amount of aromatic aldehydes with barbituric acids (barbituric acid or 1,3‐dimethylbarbituric acid) and 5‐amino‐2‐methylbenzo[d]thiazol in mixed solvent of glacial acetic acid and ethylene glycol without catalyst under microwave irradiation. This one‐pot method has the advantage of good yields (90% –93%), simple workup procedure and short reaction time (5 min).
Study of the Reactions of Fluorine‐Containing Amides with Aldehydes and the Structures of the Bisamides
Authors: ZHAO Jingwei , XIN Yong , YANG Jun , ZHU Shizheng , XU Liangzhong 
Published: June 2009

AbstractThe reactions of trifluoro or bromodifluoro acetamides with aromatic aldehydes in the presence of thionyl chloride and trifluoromethylsulfonic acid were investigated. Compared with the procedure reported previously, the yields were improved greatly and the reaction conditions were much milder. Both intra‐ and intermolecular weak interactions were discussed in detail based on the X‐ray diffraction analysis of 3aa and 3ab.
Synthesis, Characterization and Biological Activities of a New Fluorescent Indicator for the Intracellular Calcium Ions
Authors: HE Huaizhen , LEI Lei , LI Jianli , SHI Zhen 
Published: June 2009

AbstractA novel calcium‐selective fluorescent indicator Fluo‐3M AM was synthesized by introduction of a methyl group into the Ca2+‐chelating moiety and adequately characterized by spectral methods (1H NMR, GC‐MS, IR and MALDI‐TOF MS). Meanwhile, its fluorescence spectra and some biological activities have been also studied. The results indicate that the new fluorescent indicator has relatively high affinity to calcium and a strong fluorescence signal, which should be useful for biomedical researchers to investigate the effects of calcium ions in biosystems.
Interpenetrating 2D Manganese(II) Coordination Polymer Supported by 4,4′‐Bis(dimethoxyphosphorylmethyl)‐biphenyl Ligands
Authors: ZHANG Xiangdong , GE Chunhua , YIN Jing , ZHAO Yang , HE Cui 
Published: June 2009

AbstractA novel coordination polymer [Mn(bdpbp)2(NO3)2]n (1), where bdpbp=4,4′‐bis(dimethoxyphosphoryl‐ methyl)biphenyl, was prepared under mild condition. The structure has been determined by single‐crystal X‐ray diffraction analyses and further characterized by elemental analyses, IR spectra, luminescent property and thermogravimetric analyses. Structure of 1 exhibits infinite grid frameworks and forms two fold interpenetrating nets. Weak C–H···O hydrogen bonds ensure the formation and stability of a three dimensional supramolecular network.
Metabolic Syndrome Increases Mortality in Heart Failure
Authors: Tamariz Leonardo , Hassan Benjamin , Palacio Ana , Arcement Lee , Horswell Ron , Hebert Kathy 
Published: June 2009

AbstractBackgroundMetabolic syndrome (MetS) is a risk factor for diabetes, cardiovascular disease, and heart failure, but little is known about the impact of MetS in patients who already have heart failure (HF).HypothesisMetS increases mortality in HF.MethodsWe performed an analysis in 865 indigent HF patients enrolled in a HF disease management program at the Chabert Medical Center in Louisiana. All subjects were classified as having MetS if they met three or more of the National Cholesterol Education Program criteria. Mortality was defined using the Social Security Death Index. We calculated the relative hazard (RH) of death for those patients with and without MetS.ResultsThe prevalence of MetS was 40% (95% confidence interval [CI]: 37–43). These subjects had similar ages (54.3±13.4 vs 55.7±12.8 years), more likely to be female (43% vs 33%), had similar baseline ejection fraction (31.4±9.7 vs 30.0±11.0), and New York Heart Association (NYHA) classification (2.20±0.9 vs 2.15±0.9). After 2.6±2.2 years of follow‐up 24% of the MetS group died compared to 16% in the non‐MetS group (p < 0.01). The RH of death for the MetS group was 1.5 (95% CI: 1.1–2.1) when compared to the non‐MetS group after adjustment demographics, use of angiotensin‐converting enzyme (ACE) inhibitor and β‐blocker, hematocrit, creatinine, educational level, and baseline ejection fraction.ConclusionsThe prevalence of MetS is high in indigent HF patients, and it increases the risk of death. Physicians treating patients with HF need to address the current MetS epidemic in HF. Copyright © 2009 Wiley Periodicals, Inc.
Transcatheter Aortic Valve Replacement: A Potential Option for the Nonsurgical Patient
Authors: Patel Jigar H. , Mathew Sunil T. , Hennebry Thomas A. 
Published: June 2009

AbstractWith improved life expectancy, the incidence of aortic stenosis is rising. However, up to one‐third of patients who require lifesaving surgical aortic valve replacement are denied surgery due to a high operative mortality rate. Such patients can only be treated with medical therapy or percutaneous aortic valvuloplasty, neither of which has been shown to improve mortality. With advances in interventional cardiology, transcatheter methods have been developed for aortic valve replacement. Clinical trials are investigating these devices in patients with severe aortic stenosis that have been denied surgery. Preliminary results from these trials suggest that transcatheter aortic valve replacement (TAVR) is not only feasible, but an effective way to improve symptoms. In this review, we describe the current technology and display available outcome data. Though technical challenges and operator learning curve limit optimal use of the current technology, continued experience and advancements in technology may one day make TAVR a viable alternative to traditional surgical aortic valve replacement. Copyright © 2009 Wiley Periodicals, Inc.
Two‐Year Outcomes of the Sirolimus‐Eluting Stent According to Unprotected Left Main Lesion
Authors: Kim Ung , Park Jong‐Seon , Seol Sang‐Hoon , Yang Tae‐Hyun , Kim Sung‐Man , Kim Dae‐Kyung , Kim Doo‐Il , Kim Dong‐Soo , Lee Won‐Jae , Lee Sang‐Hee , Hong Geu‐Ru , Shin Dong‐Gu , Kim Young‐Jo , Shim Bong‐Sup , Cho Yoon‐Kyung , Kim Hyung‐Seop , Nam Chang‐Wook , Hur Seung‐Ho , Kim Kwon‐Bae , Kim Yoon‐Nyun 
Published: June 2009

AbstractBackgroundThe data of long‐term outcomes of sirolimus‐eluting stent (SES) according to lesion location of unprotected left main coronary artery (LMCA) is scarce.HypothesisThe purpose of this study was to evaluate the long‐term outcomes after implantation of the SES in LMCA.MethodsA total of 84 patients (51 males) who had undergone SES implantation for the treatment of native LMCA stenosis were enrolled. The patients were divided into 2 groups based on angiographic lesion location: those with significant stenosis in the ostium and/or body (group 1; n = 39) and those involving bifurcation (group 2; n = 45).ResultsAll of the group 1 patients were treated with simple lesion coverage while different stenting techniques were used in group 2 (cross‐over: 44.8%, T: 6.7%, kissing: 37.8%, and crush techniques: 11.1%). The 8‐month quantitative angiographic findings and in‐hospital and 2 year rates of major adverse cardiac events (MACE) were compared between the 2 groups. Although angiographic success and in‐hospital MACE rates were similar in both groups with 1 cardiac death due to acute stent thrombosis in group 2, at 2‐year follow‐up, the MACE rate was significantly higher in group 2 than in group 1 at 2 years (22.2% vs 2.6%, respectively, P = 0.008). Coronary angiography revealed a significantly higher binary restenosis rate in group 2 compared with group 1 (20% vs 0%, respectively, P = 0.003).ConclusionsInterventional treatment using SES in left main lesions showed favorable short‐term and long‐term outcomes in selected patients with lesion location being an important determinant of clinical and angiographic outcomes. Copyright © 2009 Wiley Periodicals, Inc.
Cataract Surgery — A Personal Account or “One Satisfied Patient”
Authors: Richard Conti C. 
Published: June 2009

AbstractMost cataracts are related to aging. By age 80, more than half of all Americans either have a cataract or have experienced cataract surgery.Although this editorial does not have any direct relationship to cardiovascular medicine, it may have some applicability with your patients, many of whom may be older rather than younger, and have cardiovascular disease in addition to visual problems perhaps due to cataracts. Copyright © 2009 Wiley Periodicals, Inc.
Adsorption of Selenium Using Bagasse Fly Ash
Authors: Wasewar Kailas L. , Prasad Basheshwar , Gulipalli Sekhararao 
Published: June 2009

AbstractThe present work involves the study of Se(IV) adsorption onto bagasse fly ash. The adsorbents were coated with a ferric chloride solution for the effective removal of selenium. The physico‐chemical characterization of the adsorbent was carried out using standard methods, e. g., proximate analysis, scanning electron microscopy, Fourier transform infrared spectroscopy, thermo‐gravimetric analysis and differential thermal analysis. Batch experiments were carried out to determine the effect of various parameters such as adsorbent dose, initial pH, contact time, and temperature on the adsorption process. Results obtained from these studies were analyzed using various kinetic models and isotherms. Se(IV) adsorption onto adsorbent was high at low pH values, and decreased with an increase in initial pH. A temperature study showed that the uptake of Se(IV) was greatest at 293 K, within the temperature range studied. The parameters of pseudo first order, pseudo second order, and Weber‐Morris intra‐particle kinetic models were determined. Equilibrium isotherms were analyzed using Langmuir, Freundlich, and Temkin isotherms. Error analyses were also carried out using hybrid fractional error function and Marquardt's percent standard deviation.
Occurrence, Dynamics and Reactions of Organic Pollutants in the Indoor Environment
Authors: Salthammer Tunga , Bahadir Müfit 
Published: June 2009

AbstractThe indoor environment is a multidisciplinary scientific field involving chemistry, physics, biology, health sciences, architecture, building sciences and civil engineering. The need for reliable assessment of human exposure to indoor pollutants is attracting increasing attention. This, however, requires a detailed understanding of the relevant compounds, their sources, physical and chemical properties, dynamics, reactions, their distribution among the gas phase, airborne particles and settled dust as well as the availability of modern measurement techniques. Building products, furnishings and other indoor materials often emit volatile and semi‐volatile organic compounds. With respect to a healthy indoor environment, only low emitting products, which do not influence indoor air quality in a negative way, should be used in a building. Therefore, materials and products for indoor use need to be evaluated for their chemical emissions. This is routinely done in test cambers and cells. Many studies have shown that the types of sources in occupational and residential indoor environments, the spectrum of emitting compounds and the duration of emission cover a wide range. The demand for standardized test methods under laboratory conditions has resulted in several guidelines for determination of emission rates. Furthermore, it has now been recognized that both primary and secondary emissions may affect indoor air quality. The problem may become more dominant when components of different materials can react with each other or when catalytic materials are applied. Such products derived from indoor related reactions may have a negative impact on indoor air quality due to their low odor threshold, health related properties or the formation of ultrafine particles. Several factors can influence the emission characteristics and numerous investigations have shown that indoor chemistry is of particular importance for the indoor related characterization of building product emissions. This paper provides an overview of the current state of the art research on the mentioned topics.
Development of French Indoor Air Quality Guidelines
Authors: Mandin Corinne , Bonvallot Nathalie , Kirchner Séverine , Keirsbulck Marion , Alary René , Cabanes Pierre‐André , Dor Frédéric , Le Moullec Yvon , Mullot Jean‐Ulrich , Peel Anne‐Elisabeth , Rousselle Christophe 
Published: June 2009

AbstractIndoor air quality guidelines (IAQGs) provide safe levels of indoor pollutant concentrations below which adverse health effects are not expected to occur in the general population, including susceptible subgroups. The French Agency for Environmental and Occupational Health Safety and the French Scientific and Technical Centre for Building have been leading a national working group to develop IAQGs based on health criteria. Firstly, a list of substances of concern was established for which IAQGs should be provided, and priority substances were identified. For each substance, toxicological and epidemiological data was reported and discussed. A critical effect and, if possible, a mode of action explaining the toxicity was described. Existing health based IAQGs already established and recommended by international groups or by some countries are collected, together with available toxicity reference values from the US Environmental Protection Agency, the Agency for Toxic Substances and Disease Registry, the California Office of Environmental Health Hazard Assessment, Health Canada and the Dutch Agency for Environmental Health. After an in‐depth analysis of these values, IAQGs are proposed. The production of an IAQG for a threshold pollutant (formaldehyde) and for a non‐threshold carcinogenic compound (benzene) are presented as examples.
Exposure Risk Assessment of the Emissions of Wood Preservative Chemicals in Indoor Environments
Authors: Yu Chuck , Crump Derrick , Brown Veronica 
Published: June 2009

AbstractA collaborative study was undertaken to evaluate the sustainability of a new generation of biocides for the treatment of timbers in buildings and to validate the recyclability of the treated timbers. The evaluation included an assessment of the impact of emissions of the wood treatment chemicals during the service life of timbers and recycled wood based products. This involved emission testing of active substances (propiconazole, tebuconazole, permethrin and dichlofluanid) and volatile organic compounds (VOCs) from timber pretreated or coated using formulated products. The German AgBB method for evaluating VOC emissions from construction products was used to discuss the relative risk of the treated timbers. The emission rates of the active substances from the treated timbers were compared to the ADI (Acceptable Daily Intake) values given in the draft reports from the EU Biocides Directive, 98/8/EC, to determine the exposure risk to building occupants. As a part of this study, the emissions of the active substances from the stud frame of a newly built test cabin were monitored over a two year period.
Pharmacophore‐Based Discovery of Small‐Molecule Inhibitors of Protein–Protein Interactions between HIV‐1 Integrase and Cellular Cofactor LEDGF/p75
Authors: De Luca Laura , Barreca Maria Letizia , Ferro Stefania , Christ Frauke , Iraci Nunzio , Gitto Rosaria , Monforte Anna Maria , Debyser Zeger , Chimirri Alba 
Published: June 2009

AbstractThe cellular protein lens epithelium‐derived growth factor, or transcriptional coactivator p75 (LEDGF/p75), plays a crucial role in HIV integration. The protein–protein interactions (PPIs) between HIV‐1 integrase (IN) and its cellular cofactor LEDGF/p75 may therefore serve as targets for the development of new anti‐HIV drugs. In this work, a structure‐based pharmacophore model for potential small‐molecule inhibitors of HIV‐1 IN–LEDGF/p75 interaction was developed using the LigandScout software. The 3D model obtained was used for virtual screening of our in‐house chemical database, CHIME, leading to the identification of compound CHIBA‐3002 as an interesting hit for further optimization. The rational design, synthesis and biological evaluation of four derivatives were then carried out. Our studies resulted in the discovery of a new and more potent small molecule (7, CHIBA‐3003) that is able to interfere with the HIV‐1 IN–LEDGF/p75 interaction at micromolar concentration, representing one of the first compounds to show activity against these specific PPIs. Docking simulations were subsequently performed in order to investigate the possible binding mode of our new lead compound to HIV‐1 IN. This study is a valid starting point for the identification of anti‐HIV agents with a different mechanism of action from currently available antiviral drugs.
Inside Cover: Silicon Analogues of the RXR‐Selective Retinoid Agonist SR11237 (BMS649): Chemistry and Biology (ChemMedChem 7/2009)
Authors: Lippert W. Peter , Burschka Christian , Götz Kathrin , Kaupp Martin , Ivanova Diana , Gaudon Claudine , Sato Yoshiteru , Antony Pierre , Rochel Natacha , Moras Dino , Gronemeyer Hinrich , Tacke Reinhold 
Published: June 2009

AbstractThe inside cover picture shows a carbon‐based (left) and the analogous silicon‐based (right) derivative of the highly potent pan‐RXR‐selective retinoid agonist SR11237. Switching from carbon to silicon increased the biological activity by a factor of ten. To further understand this effect, both agonists were co‐crystallized with the ligand‐binding domain of hRXRα (superposition of the two crystal structures shown). For more details, see the Full Paper by R. Tacke et al. on p. 1143 ff.magnified image
Conditional relative survival of cancer patients and conditional probability of death
Authors: Bouvier Anne‐Marie , Remontet Laurent , Hédelin Guy , Launoy Guy , Jooste Valérie , Grosclaude Pascale , Belot Aurélien , Lacour Brigitte , Estève Jacques , Bossard Nadine , Faivre Jean 
Published: June 2009

AbstractBACKGROUND:Little information is available on the conditional probabilities of death among patients who survive for >5 years after a diagnosis with cancer. The objective of this study was to estimate the conditional probabilities of death for breast cancer, prostate cancer, colorectal cancer, and lung cancer in France.METHODS:The study included data from the French Network of Cancer Registries from 205,562 patients aged <75 years who were diagnosed with cancer between 1989 and 1997. The conditional probabilities of death were calculated by using a relative survival regression model in which age was included as a covariate.RESULTS:After the first year and until 10 years after diagnosis, the annual probability of death decreased dramatically for colorectal cancer: It was the same in all age groups after 3 years, and it was approximately 1% at 10 years. For prostate cancer, the decrease was not as great, and the conditional probability of death remained higher among younger patients at >4% at 10 years. During the 3 years after diagnosis, the probability of death was greater for older patients with breast cancer; then, it decreased less for younger patients compared with older patients, leading to a greater conditional probability of death among younger patients at 4 years and up to 10 years. The annual probability of death in patients with lung cancer decreased for both sexes but remained substantially higher for men than for women, reaching approximately 8% and 5%, respectively, at 10 years.CONCLUSIONS:Further studies would facilitate a better understanding of the observed differences in relative survival within European countries. Cancer 2009. © 2009 American Cancer Society.