bluuebunny/crossref_metadata_2025_split huggingface dataset:
The impact of changes in LH levels in flexible antagonist protocols on the clinical outcomes of fresh IVF/ICSI cycles in populations of POSEIDON groups 1 and 2: a retrospective cohort study
Authors: Zhou Yuan , Lin Yanying , Chen Lili , Huang Lisheng , Yang Yizhen , Zheng Beihong 
Published: May 2024

Abstract

Objective: To investigate the impact of changes in luteinizing hormone (LH) levels during ovulation induction using flexible gonadotropin-releasing hormone antagonist (GnRH-A) regimens in POSEIDON groups 1 and 2 on the clinical outcomes of fresh in-vitro fertilization (IVF)/ intracytoplasmic sperm injection (ICSI) cycles.
Method: A retrospective analysis was conducted on the clinical data of females in POSEIDON groups 1 and 2 who underwent the IVF/ICSI used flexible GnRH-A regimen at the Reproductive Medicine Center of Fujian Maternal and Child Health Hospital from January 2017 to December 2022. According to the values of change in LH [(LH level on the trigger day − baseline LH)/baseline LH], the study subjects were divided into 7 groups. The general information, laboratory indicators, and clinical outcomes of each group were compared.
Results: Significant difference was observed in terms of the number of retrieved eggs, mature eggs, fertilization number (2PN number), cleavage, and excellent embryos among all groups (all P values < 0.05). The number of eggs retrieved in group A was significantly lower than that in groups E, F, and G (P = 0.042, 0.011, and 0.000, respectively). The number of eggs retrieved in group B was significantly lower than that in group G (P = 0.013). The number of mature eggs in group A was significantly lower than that in groups E, F, and G (P = 0.017, 0.023, and 0.000, respectively). Group B exhibited significantly lower number of mature eggs than group G (P = 0.005). The 2PN number in group A was significantly lower than that in groups E, F, and G (P = 0.033, 0.016, and 0.000, respectively). The cleavage count of group A was significantly lower than that of groups E and G (P = 0.035 and 0.000, respectively).
Conclusion: The use of a flexible GnRH-A regimen to induce ovulation in the POSEIDON groups 1 and 2 can lead to better clinical outcomes. This involves adjusting the dosage of gonadotropin(Gn) and antagonists during the controlled ovarian stimulation(COS) process, to control the LH level on trigger day and allow it to decrease within the range of 0%–100% from baseline (with optimal range being ≥ −100% to −50%).
Assocations of Common Mental Disorder Severity With Treatment Contact and Treatment Intensity, and Its Changes Over Twelve Years
Authors: Nuyen Jasper , Dorsselaer Saskia van , Tuithof Marloes , Luik Annemarie , Kroon Hans , Have Margreet ten 
Published: May 2024

Abstract

Purpose. To guide formal healthcare resource allocation for common mental disorders (CMDs), this study updates and expands earlier findings on the associations of CMD severity with treatment contact and treatment intensity. Methods. Baseline data (2019–2022) of NEMESIS-3, a prospective study of a representative cohort of Dutch adults (18–75 years), were used. Severity of 12-month CMDs was assessed with the CIDI 3.0. Using multivariate analyses, its associations with 12-month treatment contact and treatment intensity for emotional/substance-use problems were examined, both for general medical care (GMC) only and mental health care (MHC). Changes over time were identified by making comparisons with baseline data (2007–2009) of NEMESIS-2. Results. Persons with severe CMDs were more likely to have made contact with GMC only or MHC compared to persons without CMDs. Between 2007–2009 and 2019–2022 the contact rate with GMC only increased stronger for moderate cases, while the increasing contact rate with MHC did not differ across CMD severity levels. Both among users of GMC only and MHC, severe cases had a higher likelihood of receiving treatment of the highest intensity level compared to persons without CMDs. Between 2007–2009 and 2019–2022 the rate of highest treatment intensity increased stronger for severe cases using GMC only, while a trend towards a stronger decrease in this rate was found for severe cases using MHC. Conclusion. Evidence was found that treatment of CMDs in GMC has been strengthened in the past twelve years. No indications were found that allocation of MHC resources to severe cases has improved. Word count abstract: 250
Study of risk factors for acute coronary syndrome in young people
Authors: Hamdan Diaa Yahya , Alarbid Talal Haitham , Ali Diaa Haj , Nabulsi Ahmad 
Published: May 2024

Abstract

Background
Acute coronary syndrome is a condition in which there is a lack of blood supply and oxygen to the heart muscle, due to blockage or narrowing of the coronary arteries, which leads to a mismatch between the supply and demand of oxygen.
Acute coronary syndrome (ACS) refers to a group of conditions that include ST-elevation myocardial infarction (STEMI), non-ST elevation myocardial infarction (NSTEMI), and unstable angina. It is a type of coronary heart disease (CHD), which is responsible for one-third of total deaths in people older than 35.
Research Materials and Methods
A retrospective cohort study (COHORT) was conducted On a random group of patients from January 2018 to January 2023. The research approval (CV 8093) was given by the Ethics Committee of the Faculty of Medicine, Damascus University, Syria.
Results
The sample included 250 patients, of which 20 were excluded, leaving us with 230 cases on which research and statistics were conducted. 19.1% were females and 80.9% were males. Participants are classified into three groups, with the age group (36 – 40) years representing the majority 71.7%.
Patients with coronary disease were divided into 3 categories according to the disease type. Research and statistics showed that 60.9% of them presented with unstable angina.
The results showed that the largest percentage of patients suffering from unstable angina were from the age group 36-40 years, at a rate of 63.6%, and the relationship was statistically significant (p-value=0.01).
Conclusion
It is necessary to hold medical seminars on coronary heart diseaseand explain the difference between its types.
Gene Regulatory Network topology mediates the role of diffusible components in cellular patterns: the root epidermis of Arabidopsis thaliana as a study system
Authors: Álvarez-Buylla Elena R , Castillo-Jiménez Aaron , Arroyo Adriana Garay , Sánchez María de la Paz , García.Ponce Berenice , Martinez-Garcia Juan Carlos 
Published: May 2024

Abstract

The differentiation of two cell types in the root epidermis of Arabidopsis thaliana-atrichoblasts, which give rise to hair cells, and atrichoblasts, which do not develop into hair cells-is orchestrated by a complex regulatory network of transcription factors and hormones. These elements synchronize spatially and temporally to create a characteristic interspersed pattern of hair and non-hair cells. Previous models have established a minimal regulatory network that captures the wild-type (WT) phenotype and some mutants, yet these models often fail to account for most mutant phenotypes, thereby limiting their predictive scope. In this study, we introduce an enhanced model, a diffusion-coupled regulatory genetic network, or meta-GRN, which extends our research group's previously published work. This model aims to describe the organizational patterns of the root epidermis more accurately. It successfully recovers, fully or partially, the phenotypes of loss-of-function mutants related to the identity regulators of epidermal cell types included within the model. Moreover, this expanded model quantitatively describes the distribution of trichoblasts and atrichoblasts relative to cortex cells, facilitating comparisons of cell type proportions at various positions against those reported in analyzed mutants. Crucially, the model highlights the role of diffusion processes in the lateral inhibition mechanism that governs network dynamics, underscoring their pivotal role in pattern formation in both the WT phenotype and various mutants.
Research on evaluation index of road base grouting quality based on GPR image recognition method
Authors: Chen Deqiang , Lu Changheng , Chang Zhenchao , Jiang Hongliang , Li Zhiyuan 
Published: May 2024

Abstract

This paper presents a case study on a road base grouting project, utilizing 3-D Ground Penetrating Radar (GPR) technology to obtain plane amplitude gray maps before and after grouting at different depths of the road base. Statistical analysis was conducted by extracting gray values from these maps using image recognition technology. The study yielded the following conclusions: Firstly, a comparison of 80 sets of gray maps revealed a higher level of uniformity in the maps after grouting, indicating the effective reinforcement of the road base through the grouting process. Secondly, the normal distribution curves plotted using the extracted gray values showed that the curve after grouting had a smoother shape and a lower peak value compared to the curve before grouting. Finally, while there was no significant correlation between the expected value and grouting quality, the standard deviation exhibited a significant correlation. Therefore, it is recommended to assess grouting quality qualitatively through the examination of the normal distribution curve and quantitatively by considering the standard deviation. These findings provide valuable insights for evaluating grouting quality in similar projects, contributing to the improvement of road construction and maintenance practices.
Degradability and remineralization of peat-derived terrestrial dissolved organic carbon in the Sunda Shelf Sea
Authors: Chen Yuan , Müller Moritz , Cobb Alexander R. , Sukri Rahayu Sukmaria , Zinke Jens , Nagarajan R. , Sharveen R. , Ali Abdulmajid Muhammad , Martin Patrick 
Published: May 2024

Abstract

The remineralization of terrestrial dissolved organic carbon (tDOC) plays an important role in coastal carbon and nutrient cycling, and can affect primary productivity and seawater pH. However, the fate of tDOC in the ocean remains poorly understood. Southeast Asia’s Sunda Shelf Sea receives around 10% of global tDOC input from peatland-draining rivers. Here, we performed photodegradation and long-term (2 months to 1.5 years) biodegradation experiments with samples from peatland-draining rivers and from peat tDOC-rich coastal water. We used the resulting photochemical and microbial decay rates to parameterize a 1-dimensional model simulation. This indicates that 24% and 23% of the initial tDOC entering the Sunda Shelf can be remineralized from pure photo- and pure biodegradation, respectively, after 2 years (which represents an upper limit of seawater residence time on the Sunda Shelf). We also show for the first time that the biodegradation rate of Southeast Asian peat tDOC is enhanced by prior photodegradation. Accounting for this additional photo-influenced biodegradation in our model simulation causes an additional 16% of the initial tDOC remineralized. Our results suggest a notably higher contribution of photodegradation compared to other ocean margins, due to the combination of low pure biodegradation rate, high solar irradiance, relatively long water residence time on the Sunda Shelf, and the photo-enhancement of the biodegradation rate.
Stages of Change-Based Nursing Interventions for Compliance, Anemia, Cardiac Function and Inflammatory Factors in CKD Patients Undergoing Hemodialysis
Authors: Wan Deheng , Sun Jiakang , Guo Fei , Wang Yan 
Published: May 2024

Abstract

Objective
To investigate the effect of stages of change-based nursing interventions on compliance, anemia, cardiac function and inflammatory factors in CKD patients undergoing hemodialysis.
Methods
One hundred CKD patients admitted to our hospital from January 2023 to December 2023 were recruited and divided into two groups by random number table method: the control group (n = 50) and the observation group (n = 50). Patients in the control group underwent conventional nursing interventions, while those in the observation group underwent stages of change-based nursing interventions. The treatment compliance, anemia, cardiac function and inflammatory factor levels were compared between the two groups.
Results
The treatment compliance in the observation group was higher than that in the control group (P < 0.05), and the levels of Hb, Alb and Hct after intervention were higher than those in the control group (P < 0.05). After the interventions, the CI, SV and LVEF of the observation group were higher than those of the control group (P < 0.05), and the levels of C-reactive protein (CRP), procalcitonin (PCT) and interleukin-6 (IL-6) were lower than those of the control group (P < 0.05).
Conclusion
Stages of change-based nursing interventions are associated with various benefits in the treatment of CKD patients undergoing hemodialysis, such as enhancing their treatment compliance, improving anemia symptoms, enhancing cardiac function, and decreasing inflammatory factor levels.
Substance Use Recovery Needs among College Students Seeking Recovery Services: A Thematic Qualitative Analysis
Authors: Nichols Lindsey M. , Brown Tiffany B. , Allmendinger Angela , Hennessy Emily A. , Tanner-Smith Emily E. 
Published: May 2024

Abstract

Background
College students who are in recovery from substance use disorders face challenges related to abstaining from substance use, finding supportive social networks, and achieving their academic goals. These students may therefore need various recovery supports at their institutions to meet their needs and goals.
Methods
This study analyzed previously collected data to explore themes related to students’ experiences of recovery, including their recovery needs and challenges while also attending college. We conducted qualitative thematic analysis of data from 92 college students (48% female; M age = 21.5 years, SD = 5.6) who participated in a larger parent study of students attending Collegiate Recovery Programs in the United States. We used a phenomenological approach to guide the current study, to characterize the meaning and experience within the shared phenomenon of recovery processes among college students.
Results
Two categories emerged, and within each category, nine total themes were coded: a) intrapersonal factors: recovery-related challenges, self-care and coping, mental and behavioral health, life challenges, internal motivations, and personal attributes; and b) interpersonal/social factors: 12-step, external supports and community, college environment, and relationships.
Conclusions
Findings offer insight into barriers and facilitators to recovery among colleges students and are discussed in terms of their implications for primary stakeholders at institutions of higher education to support college students in substance use recovery.
Making Patterned Single Defects in MoS2 Thermally with the MoS2/Au Moiré Interface
Authors: LIU Lei , Bao Yang , Xu Hai , Yan Jiaxu , Jing Peng , Xu Ji-Lian , Zhan Da , Shen Dezhen 
Published: May 2024

Abstract

Normally, it is hard to regulate thermal defects precisely in their host lattice, due to stochastic nature of thermal activation. Here, we demonstrate a thermal annealing way to create patterned single sulfur vacancy (VS) defects in monolayer MoS2 with about 2 nanometer separations at sub-nanometer accuracy. Theoretically we revealed that the S-Au interface coupling reduces the energy barriers in forming VS defects and that explains the overwhelming formation of interface VS defects. We also discovered a phonon regulation by the moiré interface that effectively condenses the Γ-point out-of-plane acoustic phonons of monolayer MoS2 to its TOP moiré sites, which has been proposed to trigger the moiré-patterned thermal VS formation. The high-throughput nanoscale patterned defects presented here may pave the way towards building scalable defect-based quantum systems.
Influence Smartphones addiction on mental health and sleep quality among medical students in Sudan amids armed conflict :A cross sectional study.
Authors: Jaber Mohammed Hammad 
Published: May 2024

Abstract

Background:
Smartphone use has rapidly increased worldwide. It was estimated that worldwide use of smartphones surpassed 1 billion in 2012, which means that 1 out of 7 people use smartphones. Mobile phones have become an unavoidable part of the youth's lives and are attractive and very handy technological appliances, competent to disseminate a lot of information at their fingertips. They also include features like internet access, multimedia, and GPS navigation, in addition to their use for communication. We aimed to assess the influence of smartphone addiction on mental health and sleep quality among medical students in Sudan.
Methods:
This cross-sectional survey focused on Sudanese medical students, living inside or outside the country, who tend to be addicted to smartphones during the conflict period. The questionnaire covered various domains, including sociodemographic data, the Suboptimal Health Status questionnaire, the sleep condition indicator, the smartphone addiction scale, and depression, anxiety, and stress scales during the conflict. Data analysis was performed using the Statistical Package for Social Sciences software version 26.
Results:
A total of 1704 questionnaires were collected. Of all participants, 1176 (69.0%) were female and 528 (31.0%) were male. The mean age of the participants was 491. Age was classified: as less than 18 (40, 2.3%), 19–21 years (368, 21.6%), and more than 21 years (1296, 76.1%). More than half of the respondents (1048, 61.5%) had a low suboptimal health status questionnaire prevalence, while 656 (38.5%) had a high prevalence. 336 (31.5%) of the participants had a low rate of sleep condition indicator prevalence, while 1168 (68.5%) had a high rate according to the prevalence rate.
Conclusion:
In conclusion, our study sheds light on the significant prevalence of smartphone addiction among medical students in Sudan, with 67.6% of participants exhibiting high levels of addiction. This addiction has profound health implications, particularly in terms of negatively impacting sleep patterns. The findings underscore the need for tailored interventions and awareness programs targeting smartphone addiction, considering demographic factors such as age, gender, and marital status. Additionally, our study emphasizes the importance of further research to explore contextual factors contributing to smartphone addiction among medical students and to develop effective strategies for intervention and prevention.
Feline Leishmaniasis: Evidence-based Treatments and Challenges to be Solved
Authors: de Jesus Sousa Caroline , Ferreira Batista Joilson , Figueredo Brito Amanda Karoliny , Castelo Branco Barros Nathália , Santiago Carvalho de Oliveira Simone , Branquinha Marta Helena , Pires e Cruz Maria do Socorro , Lopes de Mendonça Ivete , Souza dos Santos André Luis 
Published: May 2024

Abstract:
Leishmaniasis is a neglected tropical disease caused by protozoa parasites
from the Leishmania genus. Vertebrate hosts acquire the infection through the bite of a
female sandfly, initiating a complex parasite development cycle. Contrary to previous beliefs
regarding cats’ resistance, these animals have recently been identified as potential
reservoirs for leishmaniasis. Clinical symptoms in cats can manifest in diverse forms, including
cutaneous, mucocutaneous, and visceral manifestations. The diagnosis of feline
leishmaniasis is complicated by nonspecific symptoms and the relatively lower specificity
of serological tests. The recommended treatment for feline leishmaniasis involves the
administration of medications; however, success varies in each cat. This review aims to
present cases of feline leishmaniasis, highlighting clinical symptoms, diagnostic methods,
therapy schedules, and outcomes. Among the 24 cases documented in the available
literature, 12 achieved successful treatment without relapses, resulting in a reduced parasite
load and improved symptoms. Three cases responded well but presented persistent
sequelae. Two feline leishmaniasis cases initially had treatment success but later experienced
recurrences. Finally, no response was observed in seven cases, leading to the euthanasia
of cats due to ineffectiveness or irregularities along the therapy. Conventional
treatments, despite potential hepatotoxicity and nephrotoxicity, exhibit a high efficacy in
reducing parasitic load, thereby improving clinical symptoms and increasing the life expectancy
of affected cats. Nevertheless, consistent adherence is crucial, as interruptions
may render the therapy ineffective and contribute to parasite resistance. Therefore, addressing
the challenges associated with feline leishmaniasis treatment necessitates the development
of new strategies to ensure a more effective and sustained approach.
Improving the Photoelectrochemical Response of Pure TiO2 Nanotube
Array by Changing Anodization Voltage in Preparation Process
Authors: Chen Shaogao , Xu Ruanchi , Xia Zhao , Zheng Xingwen , Si Yujun 
Published: May 2024

Introduction:
Enhancing the photoelectrochemical response of TiO2 nanotube arrays
(TNA) is crucial to improve the efficiency of solar energy utilization. In this work, TNA was
prepared electrochemically by anodization at single voltages of 20 V, 30 V and 40 V as well as a
special two-step voltage of 30 V-20 V, 30 V-40 V, respectively. X-ray diffraction (XRD) and
scanning electron microscopy (SEM) were used to characterize the morphology and crystalline
structure of the sample.

Methods:
The photoelectrochemical response was measured by electrochemical potentiostatic
technique. The results show TNA evenly aligns with increasing the anodization voltage.

Results:
However, there is TiO2 that does not form TNA and is dispersed as fragments on TNA
surface at a higher voltage, which adversely affects TNA’s photoelectrochemical properties.

Conclusion:
During the process of anodization, the oxidation current changes due to the switch
in voltage. A two-step voltage method enhances pure TNA's photoelectrochemical response to
visible light.
Ethosome: An Innovative Perspective of Drug Delivery
Authors: Santosh Lohakare Nilam , Gulabrao Bhamare Dr. Vaibhav , Dadaji Chavan Nikhil , Dnyaneshwar Shelar Shruti , Dattatray Mahajan Harshal , Devidas Amrutkar Dr. Rakesh 
Published: May 2024

Abstract::
Ethosome offers a unique solution to the challenges faced by conventional drug delivery
systems. In comparison to traditional liposomes and other nanocarriers, ethosomes exhibit a unique
ability to improve drug absorption, overcoming a major limitation in the Transdermal Drug Delivery
System. Their soft and flexible nano-vesicular structure facilitates faster permeation, resulting in
significantly higher transdermal flux. This scientific investigation effectively traverses the changing
landscape of ethosomes as an innovative drug delivery system. By conducting a thorough comparative
analysis, we uncover the distinct characteristics that set them apart from other nanocarriers, offering
insights into their distinct advantages. The study also includes a detailed analysis of the variables
that have a complex impact on performance, elucidating transport mechanisms and addressing
advanced facets pivotal for refined drug delivery strategies. This comprehensive overview highlights
ethosomes as a future of medicine, offering a promising future for the safe and effective treatment of
diverse diseases, impacting numerous lives.