bluuebunny/crossref_metadata_2025_split huggingface dataset:
Modular Construction of Vinylene‐Linked Covalent Organic Frameworks with Tunable Emission for Tumor Visualization
Authors: Wang Jun , Wang Jiande , Qiao Shujie , Guo Zhiyong 
Published: April 2024

AbstractCovalent organic frameworks (COFs) with ordered π structures are very promising in porous light‐emitting materials. However, most of these COFs are either poor in luminescence or lack of water‐stability. Herein, a series of isostructural D−A vinylene‐linked COFs were constructed based a new D2h symmetric linker 1,4‐bis(4,6‐dimethyl‐1,3,5‐triazin‐2‐yl)benzene (TMTA) with high crystallinity, comparative high surface area and excellent chemical/thermal stability. Impressively, their adsorption and luminescence wavelength vary with respect to the density of π‐systems in the electron‐donating group, which constitute the foundation for molecular engineering the luminescent properties of vinylene‐linked COFs. The DFT calculations further established the relationship between the luminescence properties and the donor electronic structure. Moreover, one of representative COF named FZU‐203 showed inspiring applications in bioimaging, which may further provide strategic guidance for the use of vinylene‐linked COFs as fluorescent nanoprobes in non‐invasive medical diagnosis and visualization therapy of tumors.
HPLC‐Based Automated Synthesis and Purification of Carbohydrates
Authors: Kashiwagi Gustavo A. , Petrosilli Laura , Escopy Samira , Lay Luigi , Stine Keith J. , De Meo Cristina , Demchenko Alexei V. 
Published: April 2024

AbstractReported herein is a new HPLC‐based automated synthesizer (HPLC−A) capable of a temperature‐controlled synthesis and purification of carbohydrates. The developed platform allows to perform various protecting group manipulations as well as the synthesis of O‐ and N‐glycosides. A fully automated synthesis and purification was showcased in application to different carbohydrate derivatives including glycosides, oligosaccharides, glycopeptides, glycolipids, and nucleosides.
Polymeric Nanozyme with SOD Activity Capable of Inhibiting Self‐ and Metal‐Induced α‐Synuclein Aggregation
Authors: Martínez‐Camarena Álvaro , Bellia Francesco , Paz Clares M. , Vecchio Graziella , Nicolas Julien , García‐España Enrique 
Published: April 2024

AbstractDespite decades of research, Parkinson's disease is still an idiopathic pathology for which no cure has yet been found. This is partly explained by the multifactorial character of most neurodegenerative syndromes, whose generation involves multiple pathogenic factors. In Parkinson's disease, two of the most important ones are the aggregation of α‐synuclein and oxidative stress. In this work, we address both issues by synthesizing a multifunctional nanozyme based on grafting a pyridinophane ligand that can strongly coordinate CuII, onto biodegradable PEGylated polyester nanoparticles. The resulting nanozyme exhibits remarkable superoxide dismutase activity together with the ability to inhibit the self‐induced aggregation of α‐synuclein into amyloid‐type fibrils. Furthermore, the combination of the chelator and the polymer produces a cooperative effect whereby the resulting nanozyme can also halve CuII‐induced α‐synuclein aggregation.
Efficient Chemical Prelithiation with Modificatory Li+ Solvation Structure Enabling Spatially Homogeneous SEI toward High Performance SiOx Anode†
Authors: Wang Ruoyang , Wu Yuqing , Niu Yifan , Yang Qing , Li Haoyu , Song Yang , Zhong Benhe , Yang Liwen , Chen Ting , Wu Zhenguo , Guo Xiaodong 
Published: April 2024

Comprehensive SummaryChemical prelithiation is widely proven to be an effective strategy to address the low initial coulombic efficiency (ICE) of promising SiOx anode. Though the reagent composition has been widely explored, the Li+ solvation structure, which practically plays the cornerstone role in the prelithiation ability, rate, uniformility, has rarely been explored. A novel environmentally‐friendly reagent with weak solvent cyclopentyl methyl ether (CPME) is proposed that enables both improved ICE and spatial homogeneous solid electrolyte interphase (SEI). And the prelithiation behavior and mechanism were explored focused on the Li+ solvation structure. Both theoretical investigation and spectroscopic results suggest that weak solvent feature of CPME reduces the solvent coordination number and decreases the Li+ desolvation energy. The optimized Li+ solvation structure enables high‐efficiency prelithiation that ensures the horizontal homogenization and mechanical properties of SEI. Moreover, the accompanied CPME molecules preferentially occupy positions in initial SEI, reducing the likelihood of LiPF6 decomposition and promoting longitudinal homogenization of SEI. Consequently, the efficient and homogenous prelithiation enables impressive ICE of 109.52% and improved cycling performance with 80.77% retained after 300 cycles via just 5 min soaking. Furthermore, the full cells with LiNi0.83Co0.12Mn0.05O2 (NCM831205) cathode display an enhancement in the energy density of 179.74% and up to 648.35 Wh·kg–1.
Anticonvulsant activity of Tetrahydrolinalool: behavioral, electrophysiological, and molecular docking approaches
Authors: Fonsêca Diogo V. , da Silva Pablo R. , Pires Hugo F. O. , Rocha Juliana S. , de Oliveira Leandra Eugênia G. , Reis Flavia M. S. , Cavalho Erika B. M. , Pazos Natalia D. N. , de Sousa Natália F. , Guedes Erika C. , Ribeiro Leandro R. , de Cassia S. Sá Rita , Salvadori Mirian G. S. S. , Sousa Damião P. , Scotti Marcus T. , Felipe Cicero F. B. , de Almeida Reinaldo N. , Scotti Luciana 
Published: April 2024

AbstractTetrahydrolinalool (THL) is an acyclic monoterpene alcohol, produced during linalol metabolism and also a constituent of essential oils. As described in the literature, many monoterpenes present anticonvulsant properties, and thus we became interested in evaluating the anticonvulsant activity of Tetrahydrolinalool using in mice model as well as in silico approaches. Our results demonstrated that THL increased latency to seizure onset and also reduced the mortality, in picrotoxin induced seizure tests. The results may be related to GABAergic regulation, which was also suggested in seizure testing induced by 3‐mercapto‐propionic acid. In the strychnine‐induced seizure testing, none of the groups pretreated with THL modulated the parameters indicative of anticonvulsant effect. The electrophysiological results revealed that THL treatment reduces seizures induced by pentylenetetrazole. The in silico molecular docking studies showed that the interaction between THL and a GABAA receptor model formed a stable complex, in comparison to the crystaligraphic structure of diazepam, a structurally related ligand. In conclusion, all the evidences showed that THL presents effective anticonvulsant activity related to the GABAergic pathway, being a candidate for treatment of epileptic syndromes
Pd‐Catalyzed Coupling of Bromo‐N‐ (β‐glucopyranosyl)quinolin‐2‐ones with Amides: Synthesis of N‐glucosyl‐6BrCaQ Conjugates with Potent Anticancer Activity
Authors: Redjdal Wafa , Benmahdjoub Sara , Luong Thi Thanh Hyen , Benmerad Belkacem , Le Bideau Franck , Vergnaud Juliette , Messaoudi Samir 
Published: April 2024

AbstractA series of N‐glycosyl‐ 6BrCaQ conjugates was synthesized through a Pd‐catalyzed cross‐coupling reaction between brominated N‐glycosyl quinolin‐2‐one derivatives and various nitrogen nucleophiles. Antiproliferative assays revealed that this new series of analogues represents a promising class of antitumor compounds as illustrated by the high biological activity observed for several derivatives towards different cancer cell lines compared to the non‐glycosylated congeners.
Engineering Cyanine‐ and Hemicyanine‐Based Probes for Optical Imaging of Kidney Diseases
Authors: Yi Shujuan , Liang Baoshuai , Huang Jiaguo 
Published: April 2024

AbstractMolecular optical probes play pivotal roles in in vivo imaging of biomarkers associated to kidney diseases. Relying on structural tunability and high fluorescence quantum yields, versatile optical probes have been constructed on cyanine or hemicyanine‐based scaffold in recent years. This review summaries the recent progress on the development of optical probes for imaging of kidney diseases, particularly through near‐infrared fluorescence, chemiluminescence and photoacoustic imaging modalities. The chemical design and sensing mechanisms are discussed along with applications in the detection of renal cell carcinoma and acute kidney injury. This progress provides insights and directions for the development of next generation kidney‐targeted probes and for pushing their further applications in preclinical and clinical research.
Superhydrophilic Densely‐Packed Gecko‐Like Structures by Soft‐Template Electropolymerization
Authors: Dione Pape Diene , Diouf Alioune , Dramé Abdoulaye , Orange François , Guittard Frédéric , Darmanin Thierry 
Published: April 2024

AbstractBio‐inspired by natural species and previous research works, nanotubes are prepared by soft‐template electropolymerization in micellar solution. Various thiophene‐based and carbazole‐based monomers are designed from a triphenylamine core. With one of the carbazole‐based monomers, which is fully conjugated and with a star‐like structure, gecko‐like surface structures are obtained even if the structure is not perfectly planar. Extremely long and densely packed‐microtubes are reached especially at constant potential. However, the surfaces are not both highly hydrophobic and with strong water adhesion, but are superhydrophilic. These wetting properties can be explained by a high surface energy (γSV)=41.9 mN m−1 compared to gecko foot even if the natural gecko feet are also chemically inhomogeneous, or by differences in the arrangement of the surface structures.
CSR from different perspectives: The global ESG indexes updated
Authors: Jiang Ping‐Chuan , Feng Gen‐Fu , Wang Hai‐Jie , Chang Chun‐Ping 
Published: April 2024

AbstractThe prevailing environmental, social and governance (ESG) framework is currently based on micro‐ESG indicators. Research on national ESG is often limited to theory building and policy analysis. Based on previous scholars, this paper constructs a national ESG index framework consisting of 39 indices and updates the national ESG indices for 121 countries worldwide from 1990 to 2021 using the entropy weight method, aiming to provide a set of instrumental indices that capture the status and evolution of national ESG performance. The research findings are as follows: First, the Gini coefficient shows that the gap between national ESG performance has gradually widened over time. Second, the kernel density distribution suggests that global ESG performance is on the rise. High‐income countries are placing greater emphasis on ESG growth. Third, the results of the Markov transformation matrix suggest that there is a “club convergence” in ESG performance across countries.
Polyoxomolybdate‐Based Metal–Organic Framework‐Derived Cu‐Embedded Molybdenum Dioxide Hybrid Nanoparticles as Highly Efficient Electrocatalysts for Al−S Batteries
Authors: Zhou Qiuping , Jiang Xinyuan , Zhang Xuecheng , Wang Dawei , Yang Guang , Zhou He , Wu Yuchao , Guo Fang , Chen Ming , Diao Guowang , Ni Lubin 
Published: April 2024

AbstractHigh‐performance rechargeable aluminum‐sulfur batteries (RASB) have great potential for various applications owing to their high theoretical capacity, abundant sulfur resources, and good safety. Nevertheless, the practical application of RASB still faces several challenges, including the polysulfide shuttle phenomenon and low sulfur utilization efficiency. Here, we first developed a synergistic copper heterogeneous metal oxide MoO2 derived from polymolybdate‐based metal‐organic framework as an efficient catalyst for mitigating polysulfide diffusion. This composite enhances sulfur utilization and electrical conductivity of the cathode. DFT calculations and experimental results reveal the catalyst Cu/MoO2@C not only effectively anchors aluminum polysulfides (AlPSs) to mitigate the shuttle effect, but also significantly promotes the catalytic conversion of AlPSs on the sulfur cathode side during charging and discharging. The unique nanostructure contains abundant electrocatalytic active sites of oxide nanoparticles and Cu clusters, resulting in excellent electrochemical performance. Consequently, the established RASB exhibits an initial capacity of 875 mAh g−1 at 500 mA g−1 and maintains a capacity of 967 mAh g−1 even at a high temperature of 50 °C.
Comprehensive multi‐omics analysis of resectable locally advanced gastric cancer: Assessing response to neoadjuvant camrelizumab and chemotherapy in a single‐center, open‐label, single‐arm phase II trial
Authors: Zhao Yuzhou , Li Danyang , Zhuang Jing , Li Zhimeng , Xia Qingxin , Li Zhi , Yu Juan , Wang Jinbang , Zhang Yong , Li Ke , Xu Shuning , Li Sen , Ma Pengfei , Cao Yanghui , Liu Chenyu , Xu Chunmiao , Liu Zhentian , Wei Jinwang , Zhang Chengjuan , Qiao Lei , Gao Xuan , Hou Zhiguo , Liu Chenxuan , Zheng Rongrong , Wang Du , Liu Ying 
Published: April 2024

AbstractBackgroundThe current standard of care for locally advanced gastric cancer (GC) involves neoadjuvant chemotherapy followed by radical surgery. Recently, neoadjuvant treatment for this condition has involved the exploration of immunotherapy plus chemotherapy as a potential approach. However, the efficacy remains uncertain.MethodsA single‐arm, phase 2 study was conducted to evaluate the efficacy and tolerability of neoadjuvant camrelizumab combined with mFOLFOX6 and identify potential biomarkers of response through multi‐omics analysis in patients with resectable locally advanced GC. The primary endpoint was the pathological complete response (pCR) rate. Secondary endpoints included the R0 rate, near pCR rate, progression‐free survival (PFS), disease‐free survival (DFS), and overall survival (OS). Multi‐omics analysis was assessed by whole‐exome sequencing, transcriptome sequencing, and multiplex immunofluorescence (mIF) using biopsies pre‐ and post‐neoadjuvant therapy.ResultsThis study involved 60 patients, of which 55 underwent gastrectomy. Among these, five (9.1%) attained a pathological complete response (pCR), and 11 (20.0%) reached near pCR. No unexpected treatment‐emergent adverse events or perioperative mortality were observed, and the regimen presented a manageable safety profile. Molecular changes identified through multi‐omics analysis correlated with treatment response, highlighting associations between HER2‐positive and CTNNB1 mutations with treatment sensitivity and a favourable prognosis. This finding was further supported by immune cell infiltration analysis and mIF. Expression data uncovered a risk model with four genes (RALYL, SCGN, CCKBR, NTS) linked to poor response. Additionally, post‐treatment infiltration of CD8+ T lymphocytes positively correlates with pathological response.ConclusionThe findings suggest the combination of PD‐1‐inhibitor and mFOLFOX6 showed efficacy and acceptable toxicity for locally advanced GC. Extended follow‐up is required to determine the duration of the response. This study lays essential groundwork for developing precise neoadjuvant regimens.
Heat transfer during droplet impact on a cold superhydrophobic surface via interfacial thermal mapping
Authors: Kumar Vijay , Fu Qianxi , Szeto Harrison , Zhu Yangying 
Published: April 2024

AbstractUndesired heat transfer during droplet impact on cold surfaces can lead to ice formation and damage to renewable infrastructure, among others. To address this, superhydrophobic surfaces aim to minimize the droplet surface interaction thereby, holding promise to greatly limit heat transfer. However, the droplet impact on such surfaces spans only a few milliseconds making it difficult to quantify the heat exchange at the droplet–solid interface. Here, we employ high‐speed infrared thermography and a three‐dimensional transient heat conduction COMSOL model to map the dynamic heat flux distribution during droplet impact on a cold superhydrophobic surface. The comprehensive droplet impact experiments for varying surface temperature, droplet size, and impacting height reveal that the heat transfer effectiveness () scales with the dimensionless maximum spreading radius as , deviating from previous semi‐infinite scaling. Interestingly, despite shorter contact times, droplets impacting from higher heights demonstrate increased heat transfer effectiveness due to expanded contact area. The results suggest that reducing droplet spreading time, as opposed to contact time alone, can be a more effective strategy for minimizing heat transfer. The results presented here highlight the importance of both contact area and contact time on the heat exchange between a droplet and a cold superhydrophobic surface.
Tests of evolutionary and genetic rescue using flour beetles, Tribolium castaneum, experimentally evolved to thermal conditions
Authors: Lewis Rebecca , Pointer Michael D. , Friend Lucy , Gage Matthew J. G. , Spurgin Lewis G. 
Published: April 2024

AbstractSmall, isolated populations are often characterised by low levels of genetic diversity. This can result in inbreeding depression and reduced capacity to adapt to changes in the environment, and therefore higher risk of extinction. However, sometimes these populations can be rescued if allowed to increase in size or if migrants enter, bringing in new allelic variation and thus increasing genetic diversity. This study uses experimental manipulation of population size and migration to quantify their effects on fitness in a challenging environment to better understand genetic rescue. Using small, replicated populations of Tribolium castaneum experimentally evolved to different temperature regimes we tested genetic and demographic rescue, by performing large‐scale manipulations of population size and migration and examining fitness consequences over multiple generations. We measured fitness in high temperature (38°C) thermal lines maintained at their usual ‘small’ population size of N = 100 individuals, and with ‘large’ scaled up duplicates containing N≈10,000 individuals. We compared these large lines with and without migration (m = 0.1) for 10 generations. Additionally, we assessed the effects of outcrossing at an individual level, by comparing fitness of hybrid (thermal line × stock) offspring with within‐line crosses. We found that, at the population level, a rapid increase in the number of individuals in the population resulted in reduced fitness (represented by reproductive output and survival through heatwave conditions), regardless of migration. However, at an individual level, the hybrid offspring of migrants with native individuals generally demonstrated increased longevity in high temperature conditions compared with individuals from thermal selection lines. Overall, these populations showed no evidence that demographic manipulations led to genetic or evolutionary rescue. Following the effects of migration in individuals over several generations may be the next step in unravelling these conflicting results. We discuss these findings in the context of conservation intervention.
Long‐distance dispersal in the short‐distance dispersing house sparrow (Passer domesticus)
Authors: Ranke Peter S. , Pepke Michael L. , Søraker Jørgen S. , David Gabriel , Araya‐Ajoy Yimen G. , Wright Jonathan , Nafstad Ådne M. , Rønning Bernt , Pärn Henrik , Ringsby Thor Harald , Jensen Henrik , Sæther Bernt‐Erik 
Published: April 2024

AbstractThe house sparrow (Passer domesticus) is a small passerine known to be highly sedentary. Throughout a 30‐year capture–mark–recapture study, we have obtained occasional reports of recoveries far outside our main metapopulation study system, documenting unusually long dispersal distances. Our records constitute the highest occurrence of long‐distance dispersal events recorded for this species in Scandinavia. Such long‐distance dispersals radically change the predicted distribution of dispersal distances and connectedness for our study metapopulation. Moreover, it reveals a much greater potential for colonization than formerly recorded for the house sparrow, which is an invasive species across four continents. These rare and occasional long‐distance dispersal events are challenging to document but may have important implications for the genetic composition of small and isolated populations and for our understanding of dispersal ecology and evolution.
Topological Structural Chemistry of Fused Bicycloalkanes Allowing Homeomorphic Conversions
Authors: Setaka Wataru 
Published: April 2024

AbstractFused bicycloalkanes have several structures with different orientations of the substituents, such as out,out‐, in,in, and in,out‐structures. Some bicycloalkanes can undergo homeomorphic conversions between certain structures, for instance an out,out‐structure can convert to an in,in‐structure. This homeomorphism can be achieved by one chain passing through the macroring. In this report, topological structural chemistry of fused bicycloalkanes and their analogues allowing homeomorphic conversions were reviewed. Although the concept of homeomorphism in fused bicycloalkanes was proposed 50 years ago, comprehensive research on their structural chemistry is still ongoing. These understandings are highly relevant to the fundamentals of many fields of chemistry, including structural chemistry, theoretical chemistry, natural products chemistry, and materials science.
Animation‐guided family empowerment program on perioperative care after neurosurgery: A randomized controlled trial for preventing respiratory complications
Authors: Lv Yunfen , Zhao Ziwei , Wu Xinyi , Wang Yao , Qiu Shanshan 
Published: April 2024

AbstractBackgroundThis study aimed to evaluate the effectiveness of using animation as education material for family empowerment program on perioperative care for caregivers whose children were to undergo neurosurgery.MethodsA total of 204 caregivers were randomly assigned to either the face‐to‐face oral nursing educated group (Oral Group) or the animation‐assisted nursing educated group (Animated Group). The nursing education primarily focused on instructing caregivers about the manual vibration method. The primary outcome of interest in this study was participants' knowledge level, collected by a 10‐item questionnaire. Secondary outcomes included child patients' clinical data, including hospitalization days, treatments, and signs of pneumonia.ResultsParticipants in the Animated Group exhibited significantly higher accuracy in perioperative care knowledge assessment, and patients in this group had a lower chance of requiring atomization therapy compared to the Oral Group.ConclusionsThe animation‐assisted nursing education program effectively enhances pediatric caregivers' knowledge, reduces respiratory complications after surgery, and offers valuable insights for future studies on the use of such programs to instruct caregivers.