bluuebunny/crossref_metadata_2025_split huggingface dataset:
A New Family of SO42–‐Templated 3d‐4f High‐Nuclearity Clusters: Syntheses, Structures, and Magnetic Properties†
Authors: Fan Caihong , Bai Kaipeng , Luo Qiancheng , Han Tian , Huang Chang , Zheng Yanzhen , Chen Weipeng 
Published: June 2024

Comprehensive SummaryThe precise syntheses of transition–rare‐earth metal clusters with desired structures remain a great challenge. Herein, by utilizing SO42– anion released by in‐situ decomposition of sodium dodecyl sulfate (SDS) as a template, a series of novel high‐nuclearity 3d‐4f clusters, formulated as [Ni24Pr22(μ3‐OH)31(pida)24(SO4)4(NO3)9(CH3COO)3]·Br4·(NO3)11·16H2O·25CH3OH (1, H2pida = N‐phenyliminodiacetic acid), [Ni24Nd22(μ3‐OH)31(pida)24(SO4)4(NO3)9(CH3COO)3]·Br4·(NO3)11·14H2O·24CH3OH (2) and [Ni24Gd22(μ3‐OH)36(bida)24(SO4)7(NO3)3(CH3COO)3]·(SO4)·Br4·(NO3)4·31H2O·32CH3OH (3, H2bida = N‐benzyliminodiacetic acid), have been successfully isolated. X‐ray crystal structure analyses reveal that all the cationic {Ni24RE22} cores in 1—3 possess a ball‐like structure with C3v symmetry, and can be viewed as consisting of an inner {RE22} core and an outer {Ni24} shell. From 1 and 2 to 3, due to the lanthanide contraction effect, the coordination numbers for rare‐earth metal centers in {RE22} are different, resulting in different number of SO42– and NO3– anions to support and stabilize the skeleton structures. Meanwhile, the magnetic properties of complexes 1—3 were also studied. The result revealed that complexes 1—3 show antiferromagnetic/ferrimagnetic interactions, and 3 exhibits magneto‐caloric effect at ultralow temperatures with a maximum –ΔSm (magnetic entropy change) value of 33.03 J·kg−1·K−1 at 3.0 K and 7 T.
Impact of clinical breast examination‐based screening program on care pathway, stage at diagnosis, nature of treatment, and overall survival among breast cancer patients in Morocco
Authors: Selmouni Farida , Bendahhou Karima , Sauvaget Catherine , Abahssain Halima , Lucas Eric , Muwonge Richard , Mimouni Hind , Ismaili Rachid , Bidar Soukaina , Benkaddour Fatima Zahra , Abousselham Loubna , Chami Khazraji Youssef , Belakhel Latifa , Basu Partha 
Published: June 2024

AbstractBackgroundThis study aimed to indirectly examine whether the implementation of clinical breast examination‐based screening program in Morocco has been successful in downstaging and improving survival rates. Breast cancer patients detected through the screening pathway were compared with those detected through self‐referral over the same period in terms of cancer stage at diagnosis, tumor characteristics, care delays, and survival.MethodsA prospective observational study was conducted between April 2019 and August 2020 at two major public oncology centers.ResultsA total of 896 women with confirmed breast cancer were recruited (483 were program‐referred and 413 were self‐referred). The authors did not report any significant difference between the two groups in terms of stage at diagnosis, molecular profile, or histopathological grade. Early‐stage cancer (stage I‐II) was detected in 55.7% of self‐referred participants compared to 55.5% of program‐referred participants. Median intervals between symptom recognition, pathological diagnosis, and treatment initiation were not significantly different between the two groups. Similarly, survival after treatment showed no significant difference between patients screened by the program and self‐referred patients. The 3‐year survival rate after treatment was 94.5% for patients referred through the program and 88.6% for patients not referred through the program (p = .16).ConclusionsThis study highlights the importance of equitable and timely access to high‐quality diagnosis and treatment facilities, leading to substantial downstaging and enhanced survival rates. Continued efforts to improve quality and expand coverage to include asymptomatic women will consolidate the health infrastructure gains achieved by the Moroccan breast cancer screening program.
Glucosyltriazole amphiphile treatment attenuates breast cancer by modulating the AMPK signaling
Authors: Chouhan Neeraj Kumar , Eedara Abhisheik , Talati Mamta N. , Ambadipudi Sudha S. S. S. S. , Andugulapati Sai Balaji , Pabbaraja Srihari 
Published: June 2024

AbstractBreast cancer is the second most frequent cancer among women. Out of various subtypes, triple‐negative breast cancers (TNBCs) account for 15% of breast cancers and exhibit more aggressive characteristics as well as a worse prognosis due to their proclivity for metastatic progression and limited therapeutic strategies. It has been demonstrated that AMP‐activated protein kinase (AMPK) has context‐specific protumorigenic implications in breast cancer cells. A set of glucosyltriazole amphiphiles, consisting of acetylated (9a‐h) and unmodified sugar hydroxyl groups (10a‐h), were synthesized and subjected to in vitro biological evaluation. Among them, 9h exhibited significant anticancer activity against MDA‐MB‐231, MCF‐7, and 4T1 cell lines with IC50 values of 12.5, 15, and 12.55 μM, respectively. Further, compound 9h was evaluated for apoptosis and cell cycle analysis in in vitro models (using breast cancer cells) and antitumour activity in an in vivo model (orthotopic mouse model using 4T1 cells). Annexin‐V assay results revealed that treatment with 9h caused 34% and 28% cell death at a concentration of 15 or 7.5 μM, respectively, while cell cycle analysis demonstrated that 9h arrested the cells at the G2/M or G1 phase in MCF‐7, MDA‐MB‐231 and 4T1 cells, respectively. Further, in vivo, investigation showed that compound 9h exhibited equipotent as doxorubicin at 7.5 mg/kg, and superior efficacy than doxorubicin at 15 mg/kg. The mechanistic approach revealed that 9h showed potent anticancer activity in an in vivo orthotopic model (4T1 cells) partly by suppressing the AMPK activation. Therefore, modulating the AMPK activation could be a probable approach for targeting breast cancer and mitigating cancer progression.
Forebrain commissure formation in zebrafish embryo requires the binding of KLC1 to CRMP2
Authors: Li Simo , Guo Youjia , Takahashi Miyuki , Suzuki Hisato , Kosaki Kenjiro , Ohshima Toshio 
Published: June 2024

AbstractFormation of the corpus callosum (CC), anterior commissure (AC), and postoptic commissure (POC), connecting the left and right cerebral hemispheres, is crucial for cerebral functioning. Collapsin response mediator protein 2 (CRMP2) has been suggested to be associated with the mechanisms governing this formation, based on knockout studies in mice and knockdown/knockout studies in zebrafish. Previously, we reported two cases of non‐synonymous CRMP2 variants with S14R and R565C substitutions. Among the, the R565C substitution (p.R565C) was caused by the novel CRMP2 mutation c.1693C > T, and the patient presented with intellectual disability accompanied by CC hypoplasia. In this study, we demonstrate that crmp2 mRNA could rescue AC and POC formation in crmp2‐knockdown zebrafish, whereas the mRNA with the R566C mutation could not. Zebrafish CRMP2 R566C corresponds to human CRMP2 R565C. Further experiments with transfected cultured cells indicated that CRMP2 with the R566C mutation could not bind to kinesin light chain 1 (KLC1). Knockdown of klc1a in zebrafish resulted in defective AC and POC formation, revealing a genetic interaction with crmp2. These findings suggest that the CRMP2 R566C mutant fails to bind to KLC1, preventing axonal elongation and leading to defective AC and POC formation in zebrafish and CC formation defects in humans. Our study highlights the importance of the interaction between CRMP2 and KLC1 in the formation of the forebrain commissures, revealing a novel mechanism associated with CRMP2 mutations underlying human neurodevelopmental abnormalities.
Strain‐Driven [3+2] Cycloaddition of Triazine 1‐Oxides with Arynes/Cyclooctyne: Access to Benzisoxazoles/Cyclooctene‐Fused Isoxazoles
Authors: Biswas Soumen , Sanchez‐Palestino Luis Mario , Arman Hadi , Doyle Michael P. 
Published: June 2024

AbstractThe 4‐carboxylates of 1,2,3‐triazine 1‐oxides undergo [3+2] cycloaddition with in situ generated benzynes and naphthyne and also with cyclooctyne that, following extrusion of dinitrogen, form isoxazole‐3‐propenoate derivatives in high yields and diastereocontrol. This practical method occurs at room temperature and provides a wide range of isoxazole‐based heterocycles with diverse functionality. 1,2‐Naphthyne, an unsymmetrical alkyne, forms only one regioisomeric product, exemplifying inherent regioselectivity. Although high, stereoselectivity is not 100 % in most cases, indicating that the loss of dinitrogen is stepwise. Derivative reactions of benzisoxazoles suggest their versatility.
Regulating ion transport in lithium metal batteries via metal‐organic frameworks electrolyte modulator
Authors: Yan Jiaxing , Li Jiaqi , Fang Wenqiang , Gao Yuanhang , Qin Zuosu , Sun Mingwei , Yuan Peng , Chen Gen 
Published: June 2024

AbstractLow Li+ transference number in liquid electrolytes can lead to uneven lithium deposition and dendrite growth, reducing coulombic efficiency and cycle life of lithium metal batteries. In this study, metal‐organic frameworks (MOFs) are used as electrolyte modulator to regulate Li+ transport. The ‐NH2 group introduced into MOFs can form hydrogen bonds with anions in the electrolyte, immobilizing these anions and thereby facilitating the migration of cations. As a result, a uniform and dense deposition morphology of lithium was achieved. The Li+ transference number is increased from 0.26 to 0.57. The assembled Li||Li symmetrical cell can stably cycle for over for 900 h with an average overpotential below 20 mV. In addition, the rate performance of the battery can be enhanced.
Annual degradation rates and soiling losses of photovoltaic systems composed of recent crystalline silicon technologies in temperate climate
Authors: Ishii Tetsuyuki 
Published: June 2024

AbstractThe purpose of this study is to investigate the annual degradation rates of photovoltaic (PV) systems composed of PV modules based on recent crystalline silicon (c‐Si) PV technologies. We investigated the annual degradation rates of four PV systems composed of different c‐Si PV technologies, comprising p‐type multi‐crystalline silicon with a passivated emitter rear cell, n‐type silicon heterojunction, p‐type single‐crystalline silicon (sc‐Si) with an aluminum back surface field, and n‐type (sc‐Si) solar cell technologies. These systems were located in Gunma Prefecture in Japan and were measured over 6 years. Furthermore, the effects of soiling on the annual degradation rates of these PV systems were examined by partially surface cleaning the PV arrays two times. The results obtained indicate that the apparent annual degradation rates of the PV strings before surface cleaning were 0.8, 1.6, 1.4, and 1.2%/year, respectively, because of optical losses due to dust particles. However, the inherent annual degradation rates of the PV strings after surface cleaning were 0.1, 0.6, 0.0, and 0.3%/year, respectively. These low degradation rates indicate that the PV systems composed of the recent c‐Si PV technologies all offered reasonably stable performance that was reduced by 3.6%, 5.5%, 7.3%, and 4.8%, respectively because of the effects of surface soiling, although the surfaces of the PV arrays had been washed by plentiful rainfall under their humid subtropical climatic operating conditions.
Molecular dynamics simulation of argon isochoric transition to supercritical state
Authors: Ran Yunmin , Bertola Volfango 
Published: June 2024

AbstractThe effect of the initial atoms distribution on the molecular dynamics (MD) simulation of a model atomic fluid (argon) is investigated for the case of the isochoric phase transition to the supercritical state. In particular, the case of uniformly distributed atoms in the simulation domain is compared with the case of separated liquid and vapor atoms. The sensitivity of simulations to asymmetric nanoscale perturbations in the boundary is also studied. Despite its high computational cost, the MD approach has the potential to successfully address long‐standing problems in computational fluid dynamics (CFD), especially those associated with mathematical singularities, such as contact angles, vortices, phase transitions and so forth. Unlike conventional CFD simulations, where the initial condition is the pressure or velocity distribution in the simulation domain, MD simulations also require the initial position of each molecule. Thus, it is important to understand whether a judicious choice of the initial distribution of molecules can reduce the overall computation time of the simulation. The evolution of the model fluid system during the phase transition was simulated using a Lennard‐Jones interatomic potential, corrected with the Lorentz–Berthelot mixing rule for the interactions with the solid walls. The system was allowed to relax until equilibrium, and then a Heaviside temperature step was applied to the wall to bring the system to supercritical conditions. Results show the initial choice of the atoms distribution can significantly affect the computational time, while the effect of asymmetric perturbations on the boundary is negligible.
Efficient plaintext checkable identity‐based signcryption in cyber‐physical systems towards IIoT
Authors: Hadabi Abdalla , Qu Zheng , Elhabob Rashad , Kumar Sachin , Kumari Saru , Xiong Hu 
Published: June 2024

AbstractMany different sectors are beginning to deploy cyber‐physical systems (CPS) and industrial Internet of Things (IIoT) devices, including wearables, sensors, and critical infrastructure. In order to ensure that the device's data remains confidential, it must be encrypted prior to transmission. However, obtaining authenticity and integrity in IIoT data is also crucial, and signcryption has been proposed as a solution to this challenge. An additional obstacle is how to search for signcrypted cloud data using plaintext keywords. In this paper, we suggest a plaintext‐checkable identity‐based signcryption for CPS towards IIoT (IBSC‐PCE), which enables plaintext searching of signcrypted cloud‐based data. We provide both confidentiality and integrity and also demonstrate the security of our approach under the q‐Diffie‐Hellman inversion problem (q‐DHIP). This problem has been shown to be secure in the random oracle model (ROM), which further reinforces the robustness of our approach. Compared to current state‐of‐the‐art methods, our proposed approach outperforms them.
Neural markers of reduced arousal and consciousness in mild cognitive impairment
Authors: Estarellas Mar , Huntley Jonathan , Bor Daniel 
Published: June 2024

AbstractObjectivesPeople with Alzheimer's Disease (AD) experience changes in their level and content of consciousness, but there is little research on biomarkers of consciousness in pre‐clinical AD and Mild Cognitive Impairment (MCI). This study investigated whether levels of consciousness are decreased in people with MCI.MethodsA multi‐site site magnetoencephalography (MEG) dataset, BIOFIND, comprising 83 people with MCI and 83 age matched controls, was analysed. Arousal (and drowsiness) was assessed by computing the theta‐alpha ratio (TAR). The Lempel‐Ziv algorithm (LZ) was used to quantify the information content of brain activity, with higher LZ values indicating greater complexity and potentially a higher level of consciousness.ResultsLZ was lower in the MCI group versus controls, indicating a reduced level of consciousness in MCI. TAR was higher in the MCI group versus controls, indicating a reduced level of arousal (i.e. increased drowsiness) in MCI. LZ was also found to be correlated with mini‐mental state examination (MMSE) scores, suggesting an association between cognitive impairment and level of consciousness in people with MCI.ConclusionsA decline in consciousness and arousal can be seen in MCI. As cognitive impairment worsens, measured by MMSE scores, levels of consciousness and arousal decrease. These findings highlight how monitoring consciousness using biomarkers could help understand and manage impairments found at the preclinical stages of AD. Further research is needed to explore markers of consciousness between people who progress from MCI to dementia and those who do not, and in people with moderate and severe AD, to promote person‐centred care.
Pharmacy‐led optimization of transitions of care in patients with heart failure
Authors: Fallon Julianne M. , McElhaney Emily , Anderson Keith , Lewis Daniel A. , Williams J. Bradley 
Published: June 2024

AbstractIntroductionEffective transitional care for patients with heart failure is essential to ensure optimal utilization of guideline‐directed medical therapy. Clinical pharmacists and specially trained pharmacy technicians have unique skillsets that enable them to improve care transitions.ObjectivesTo evaluate the implementation of a comprehensive pharmacy transitions of care program in an acute heart failure population.MethodsA retrospective, single center, single‐arm study evaluating pharmacy‐delivered transitions of care services (admission and discharge medication reconciliation, medication cost assessment, medication counseling, bedside delivery of discharge medications, and post‐discharge phone calls) for patients discharged from the heart failure service. The primary outcome was the completion rate of transitions of care services. Secondary outcomes included the medication intervention rate and types of interventions made, medication classes assessed for cost, discharge medication prescription captured, and 30‐day all‐cause readmissions.ResultsFive hundred and ninety‐five patients were eligible for the transitions of care program. Admission and discharge medication reconciliations were completed in 68.1% and 92.1% of patients, respectively. Medication cost assessments were completed for 39.8% of patients. Heart failure medication counseling prior to discharge was completed for 83.9% of patients. Discharge prescription capture rate was 56.5% and bedside prescription delivery was provided for 27.8% of patients. The discharge medication reconciliation intervention rate was 37.4%, with the most common intervention being dose adjustment. Post‐discharge outreach was conducted for 229 patients, with education provided for 69.4% and an intervention rate of 43.7%. The 30‐day all‐cause readmission rate was lower for patients on the heart failure service compared with the institution (10.1% vs 16.5%).ConclusionHigh rates of completion and utilization were identified after the implementation of a comprehensive pharmacy transitions of care program. Utilization of clinical pharmacists and pharmacy technicians during transitions of care improved medication access, patient education, and reduced medication‐related problems.
Identifying the risk of depression in a large sample of adolescents: An artificial neural network based on random forest
Authors: Zhou Yue , Zhang Xuelian , Gong Jian , Wang Tingwei , Gong Linlin , Li Kaida , Wang Yanni 
Published: June 2024

AbstractBackgroundThis study aims to develop an artificial neural network (ANN) prediction model incorporating random forest (RF) screening ability for predicting the risk of depression in adolescents and identifies key risk factors to provide a new approach for primary care screening of depression among adolescents.MethodsThe data were from a large cross‐sectional study conducted in China from July to September 2021, enrolling 8635 adolescents aged 10–17 with their parents. We used the Patient health questionnaire (PHQ‐9) to rate adolescent depression symptoms, using scales and single‐item questions to collect demographic information and other variables. Initial model variables screening used the RF importance assessment, followed by building prediction model using the screened variables through the ANN.ResultsThe rate of depression symptoms in adolescents was 24.6%, and the depression risk prediction model was built based on 70% of the training set and 30% of the test set. Ten variables were included in the final prediction model with a model accuracy of 85.03%, AUC of 0.892, specificity of 89.79%, and sensitivity of 70.81%. The top 10 significant factors of depression risk were adolescent rumination, adolescent self‐esteem, adolescent mobile phone addiction, peer victimization, care in parenting styles, overprotection in parenting styles, academic pressure, conflict in parent–child relationship, parental rumination, and relationship between parents.ConclusionsThe ANN model based on the RF effectively identifies depression risk in adolescents and provides a methodological reference for large‐scale primary screening. Cross‐sectional studies and single‐item scales limit further improvements in model accuracy.
Sodium‐Glucose Cotransporter‐2 Inhibitor Suppresses Endoplasmic Reticulum Stress and Oxidative Stress in Diabetic Nephropathy Through Nrf2 Signaling: A Clinical and Experimental Study
Authors: Prasad Murali Krishna , Victor Paul S. , Ganesh Goutham V. , Juttada Udayama , Kumpatla Satyavani , Viswanathan Vijay , Ramkumar Kunka Mohanram 
Published: June 2024

AbstractDiabetic nephropathy (DN), a severe complication of type 2 diabetes mellitus (T2DM), is marked by heightened endoplasmic reticulum stress (ERS) and oxidative stress (OS) due to protein misfolding and free radical generation. We investigated the sodium‐glucose co‐transporter‐2 inhibitor (SGLT2i), canagliflozin (Cana), in alleviating ERS and OS in DN patients and THP‐1 cells under hyperglycemic condition. A total of 120 subjects were divided into four groups, with 30 subjects in each group: healthy controls, T2DM individuals, DN patients receiving standard treatment, and those treated with Cana. The control group had no history of diabetes, cardiovascular or renal diseases, or other comorbidities. Cana was administered at doses of either 100 or 300 mg per day based on the estimated glomerular filtration rate (eGFR) value of DN individuals, with a mean follow‐up of 6 months. Additionally, THP‐1 monocytes were exposed to HGM (33.3 mM glucose with a cytokine cocktail of TNF‐α and IFN‐γ at 50 ng/mL each) to evaluate the relative levels of ERS, OS markers, and nuclear factor erythroid 2‐related factor 2 (Nrf2), the transcription factor regulating cellular redox, which is downregulated in diabetes. Our results revealed that ERS markers GRP78 and PERK, as well as OS markers TXNIP and p22phox, were elevated in both DN patients and HGM‐treated THP‐1 monocytes and were reduced by Cana intervention. Furthermore, Cana regulated the phosphorylation of Nrf2, Akt, and EIF2α in HGM‐treated monocytes. In conclusion, our findings highlight the role of Cana in activating Nrf2, thereby attenuating ERS and OS to mitigate DN progression.