bluuebunny/crossref_metadata_2025_split huggingface dataset:
Antipsychotic-Induced QT Prolongation and Torsade de Pointes in Patients with Mental Disorders: A Review
Authors: Nasyrova R. F. , Kidyaeva A. V. , Petrova M. M. , Shnayder N. A. 
Published: May 2024

INTRODUCTION. The high risk of life-threatening ventricular arrhythmias, particularly Torsade de Pointes (TdP), makes QT prolongation one of the most significant adverse drug reactions (ADRs) due to cardiotoxicity associated with antipsychotics (APs).AIM. This study aimed to systematise information about AP effects on the QT interval duration and TdP risk in patients with mental disorders and to provide recommendations on preventive measures for practising psychiatrists and clinical pharmacologists.DISCUSSION. The authors searched information in PubMed, eLIBRARY.RU, and Google Scholar. The analysis included full-text articles on the results of placebo-controlled studies, crossover studies, case–control studies, systematic reviews, meta-analyses, and Cochrane reviews published from 1 September 2013 to 30 September 2023. The main mechanism of AP cardiotoxicity is the inhibition of voltage-gated ion channels (primarily potassium channels) in the cardiomyocyte membrane. Most first-generation APs are associated with dose-dependent QTc prolongation; thioridazine, chlorpromazine, and levomepromazine pose the highest risk of QTc prolongation and TdP. The results of this review do not support the hypothesis of a lower risk of QTc prolongation with next-generation APs than with first-generation APs. The correlation between serum AP levels and QTc prolongation severity is less characteristic of secondand third-generation APs. However, all second-generation APs lengthen the QTc interval and increase the risk of TdP, with clozapine and olanzapine posing the highest risk. Depending on the risk of QTc prolongation, APs can be divided into 3 groups: low-risk products (aripiprazole, lurasidone, cariprazine, paliperidone, and zuclopentixol), moderate-risk products (quetiapine, perphenazine, fluphenazine, olanzapine, clothiapine, and haloperidol), and high-risk products (chlorpromazine, promazine, clozapine, levomepromazine, and ziprasidone). The relationship between AP-induced QTс prolongation and TdP is ambiguous. If an AP exerts a homogeneous effect on cardiomyocytes, the risk of TdP remains low despite significant QTс prolongation.CONCLUSIONS. The summarised data on AP effects on QT interval duration and TdP risk in patients with mental disorders as well as the proposed recommendations for reducing TdP risk may be in demand by psychiatrists and clinical pharmacologists selecting AP and may help minimise the likelihood of potentially fatal AP-induced arrhythmogenic cardiac ADRs.
Sosialisasi Mengenai Cara Pembuatan Pembukuan Dalam Akuntansi Dasar di Panti Asuhan Al Farhan Yayasan Darussalam
Authors: Damayanti Riska , Sopiyana Muhammad , Maharani Maharani 
Published: May 2024

Tujuan dari pengabdian ini adalah untuk mempersiapkan SDM yang berkualitas kepada masyarakat terutama para bendaharawan atau yang bertanggung jawab terhadap keuangan Panti Asuhan Al Farhan Yayasan Darussalam agar bisa paham mengenai pembuatan pembukuan akuntansi dasar dengan baik. Pelaksanaan PKM dilakukan dengan memberikan Sosialisasi, arahan dan pengetahuan dalam penyusunan laporan keuangan yang baik dan benar sehingga para peserta dan bagian yang memegang pembukuan dapat meningkatkan kemampuan dan kemahiran mereka dalam pembuat dan menyusun laporan keuangan secara baik dan benar sesuai dengan standar akuntansi keuangan. Dari hasil kegiatan Pengabdian Kepada Masyarakat maka dapat disimpulkan sebagai berikut: Adanya peningkatan pengetahuan untuk para peserta khususnya bendaharawan dan pihak yang bertanggung jawab laporan keuangan mengenai cara pembuatan, penyajian dan pelaporan laporan keuangan.
Seberapa Besar Pengaruh Metode Pembelajaran Talking Stick Pada Hasil Belajar Siswa SD/MI?
Authors: Rizky Muhammad , Jadidah Ines Tasya , Eprilia Winda , Shawmi Ayu Nur , Saputra Agra Dwi 
Published: May 2024

The acquisition of learning outcomes of Indonesian students in PISA in 2019 occupies the bottom 6 out of 77 countries, the latest PISA results in 2023 also show aligned results where they occupy the bottom 15 of 88 countries where the subject matter begins to emerge from the elementary / MI level. This study aims to examine how much influence the talking stick method has on students' learning outcomes, especially at the elementary / MI level. The research method used is a quantitative meta-analysis type with a comparison of group contrast design. The population in the study was 191 articles from the Google Scholar, DOAJ, and Research Gate databases. The sampling technique is an inclusion criterion. The number of samples used is 10 articles that fit the criteria. The effect of all studies was 1,633 for studies with a sample of < 30 of 1,576 and a sample of > 30 of 1,727 and a P-value hypothesis test result of 0.001. Based on this, the author concludes that the talking stick learning method has a significant effect and has a huge effect on influencing the learning outcomes of elementary / MI students, especially used when the number of students is> 30. So that this method can be a solution to overcoming the problem of obtaining student learning outcomes in Indonesia.
The Urban Morphology of Edirne
Authors: Erdoğan Nevnihal 
Published: May 2024

Serving as a cultural center and a border and a university town, Edirne is an important city of Turkey. Edirne also has historical significance as one of the three historical capitals of the Ottoman Empire (the other two are Bursa and Istanbul, respectively). The history of Edirne dates back to the 35th century BCE. This historically prosperous city hosts many monuments from the Ottoman period; however, there are only a few urban and architectural remains from other periods.The creation of the form of the city of Edirne is an example of synoecism, by which a group of small elements in an open pattern of organization, i.e., not subject to a rigid preconceived order, coalesce over time to form a larger entity.The form of Edirne is the result of three distinct types of urban development that are characteristic of three eras in the city's history: Roman/Byzantine, Ottoman, and Modern. The Roman/Byzantine form was incorporated into the Ottoman city that, in turn, was converted into a more homogeneous form in the modern era. Both the Roman/Byzantine and Ottoman patterns persist in the modern city. In this article, the city of Edirne is considered as a whole and the morphology of Edirne is shown to be an organic urban development model.
Determining value in the treatment of activated PI3Kδ syndrome in Spain: a multicriteria decision analysis from the perspective of key stakeholders
Authors: Gil Alicia , Reyes Abad María , Alerany Carmen , Alsina Laia , López Granados Eduardo , Neth Olaf , Poveda José Luis , Rivière Jacques G. , Rodríguez-Gallego Carlos , Tutein Nolthenius Joanne B. , Figueiredo Raquel , Subías Labazuy Silvia 
Published: May 2024

Introduction: Activated phosphoinositide 3-kinase (PI3K)δ syndrome (APDS) is an ultra-rare inborn error of immunity (IEI) combining immunodeficiency and immune dysregulation. This study determined what represents value in APDS in Spain from a multidisciplinary perspective applying multicriteria decision analysis (MCDA) methodology.
Methods: A multidisciplinary committee of nine experts scored the evidence matrix. A specific framework for orphan drug evaluation in Spain and the weights assigned by a panel of 98 evaluators and decision-makers was used. Re-evaluation of scores was performed.
Results: APDS is considered a very severe disease with important unmet needs, including misdiagnosis and diagnostic delay. Current management is limited to treatment of symptoms with off-label use of therapies supported by limited evidence. Therapeutic benefit is partial, resulting in limited disease control. Haematopoietic stem cell transplantation (HSCT), the only potential curative alternative, is restricted to a reduced patient population and without evidence of long-term efficacy or safety. All options present a limited safety profile. Data on patients’ quality of life are lacking. APDS is associated with high pharmacological, medical and indirect costs.
Conclusions: APDS is considered a severe disease, with limited understanding by key stakeholders of how treatment success is assessed in clinical practice, the serious impact that has on patients and the associated high economic burden. This study brings to light how MCDA methodology could represent a useful tool to complement current clinical and decision-making methods used by APDS experts and evaluators.
The more, the better? A multivariate longitudinal study on L2 motivation and anxiety in EFL oral presentations
Authors: Wu Hao 
Published: May 2024

IntroductionFor decades, oral presentations have become a common method of assessment in language learning classrooms. Nonetheless, anxiety is a persistent negative feeling pervasive in EFL learners. Although applied linguistic research suggests that there is a relationship between motivation and anxiety, the nature and direction of this relationship remain inconsistent.MethodsTo tackle this concern, this mixed-methods longitudinal study aimed to investigate the growth trajectories of Chinese EFL learners’ L2 motivation and anxiety in oral presentations. The participants were 171 second-year undergraduate medical students who attended an English for Academic Purposes (EAP) course. They delivered four oral presentations and reported their L2 motivation and anxiety levels in questionnaire surveys.Results(1) As the number of EFL learners giving oral presentations increased, the L2 motivation levels increased, and the anxiety levels decreased. (2) Those who were initially more anxious about giving oral presentations had higher decrease rates during the four oral presentations. (3) There was co-development but inverse relationships between ideal L2 self and anxiety and between ought-to L2 self and anxiety, although a complete parallel process model was not established.DiscussionThese findings suggest that students’ perceptions of L2 motivation interact with anxiety levels over time but in a sophisticated fashion. Finally, pedagogical implications for EFL oral presentation instruction are provided.
Differences in IDO1+ dendritic cells and soluble CTLA-4 are associated with differential clinical responses to methotrexate treatment in rheumatoid arthritis
Authors: Malik Anikó E. , Slauenwhite Drew , McAlpine Sarah M. , Hanly John G. , Marshall Jean S. , Issekutz Thomas B. 
Published: May 2024

ObjectiveAntigen-presenting dendritic cells (DCs) and monocytes play an essential role in rheumatoid arthritis (RA) pathogenesis, however, their tolerogenic potential remains unclear. Herein, the tolerogenic profiles of DCs are characterized in treatment-naïve RA patients to determine their role to inflammatory arthritis management.MethodsThirty-six treatment-naïve RA patients were enrolled, of which 62% were non-responders to methotrexate (MTX) monotherapy based on disease activity score (DAS) after 6-months of therapy. DC and monocyte subset frequencies, activation (CD40, CD86, CD209 expression), and tolerogenic profile (intracellular indoleamine-2,3-dioxygenase [IDO1] and cytotoxic T lymphocyte antigen 4 [CTLA-4] expression) were examined in the baseline peripheral blood by multicolor flow-cytometry. Soluble CTLA-4 (sCTLA-4) levels in plasma were measured.ResultsDC subsets were decreased in RA compared to healthy controls (HC), and the frequency of conventional DCs (cDC) inversely correlated with inflammatory markers and improvement in disease activity. CD141+ cDC1s were the major IDO1-expressing cells. IDO1+cDC1s were reduced in RA patients compared to HC. The baseline frequency of IDO1+cDC1s inversely correlated with improvement in disease activity. CTLA-4 expression in CD1c+ cDC2s and monocytes was lower in RA patients compared to HC. Moreover, MTX-responders had a significantly lower frequency of IDO1+cDC1 cells and higher level of sCTLA-4 in the plasma compared to MTX non-responders. There was a strong predictive association of low IDO1+cDC1 cells, low sCTLA-4 and non-response to MTX.ConclusionsOur findings reveal altered DC and monocytes immunophenotypes that are associated with RA pathology and treatment response. The frequencies of tolerogenic IDO1+cDC1s and the low level of sCTLA-4 are strongly associated with MTX non-responsiveness and therapeutic outcome. These results suggest that investigation of the association IDO1+cDC1 and sCTLA-4 with response to treatment may be more generalizable to other autoimmune diseases.
Immune cell infiltration and prognostic index in cervical cancer: insights from metabolism-related differential genes
Authors: Ma Boyi , Ren Chenlu , Yin Yadong , Zhao Shuhua , Li Jia , Yang Hong 
Published: May 2024

BackgroundCervical cancer remains a significant gynecologic malignancy in both China and the United States, posing a substantial threat to women’s lives and health due to its high morbidity and mortality rates. Altered energy metabolism and dysregulated mitochondrial function play crucial roles in the development, growth, metastasis, and recurrence of malignant tumors. In this study, we aimed to predict prognosis and assess efficacy of anti-tumor therapy in cervical cancer patients based on differential genes associated with mitochondrial metabolism.MethodsTranscriptomic data and clinical profiles of cervical cancer patients were retrieved from the TCGA and GEO databases. Differential gene-related cellular pathways were identified through GO, KEGG, and GSEA analyses. Prognostic indices were constructed using LASSO regression analysis. Immune cell infiltration was assessed using CIBERSORT and ssGSEA, and the correlation between immune checkpoint inhibitor genes and differential genes was examined. Tumor mutation load (TMB) and its association with prognostic indices were analyzed using nucleotide variant data from the TCGA database. Patient response to immunotherapy and sensitivity to antitumor drugs were determined using the TIDE algorithm and the oncoPredic algorithm, respectively.ResultsA prognostic index based on metabolism-related differential genes was developed to predict the clinical outcome of cervical cancer patients, enabling their classification into two distinct subtypes. The prognostic index emerged as an independent risk factor for unfavorable prognosis. The high-index group exhibited a significantly worse overall prognosis, along with elevated tumor mutation burden (TMB), increased immune cell infiltration, and lower TIDE scores, indicating a potential benefit from immunotherapy. Conversely, the low-index group demonstrated increased sensitivity to metabolism-related antitumor agents, specifically multikinase inhibitors.ConclusionThe aim of this study was to develop a prognostic index based on differential genes associated with mitochondrial metabolism, which could be used to predict cervical cancer patients’ prognoses. When combined with TIDE and TMB analyses, this prognostic index offers insights into the immune cell infiltration landscape, as well as the potential efficacy of immunotherapy and targeted therapy. Our analysis suggests that the Iron-Sulfur Cluster Assembly Enzyme (ISCU) gene holds promise as a biomarker for cervical cancer immunotherapy.
Metal in biological samples from electronic cigarette users and those exposed to their second-hand aerosol: a narrative review
Authors: Batista Diane Rezende , Coelho Liana Sousa , Tanni Suzana Erico , de Godoy Irma 
Published: May 2024

IntroductionElectronic nicotine delivery systems (ENDS) are gradually becoming more popular, particularly, among today’s youth. Despite being marketed as safe by the tobacco industry, the notable absence of regulation in their composition is evident. Both the generated fluids and aerosol exhibit a wide variety of substances that are not yet fully identified. In addition to additives, the aerosol contains metals, the presence of which can be attributed to the excessive heating of metallic filaments used in vaporizing the liquid.ObjectiveThis review aimed to identify and describe studies that have assessed metal levels in biological samples obtained from electronic cigarette users and those exposed to their second-hand aerosol. This involved detailing the types and concentrations of metals identified and the biological samples in which the metals were detected.MethodsTwo independent researchers conducted searches in the MEDLINE and EMBASE databases to identify studies that measured the metal levels in human non-invasive biological samples from electronic cigarette users and second-hand exposure. Data were presented as a narrative review.ResultsIn total, 18 articles were included in this review. Overall active and passive exposure to ENDS was related to higher levels of many metals, including lead and cadmium, in biological samples. ENDS users, in general, have lower metal concentrations in biological samples compared to the users of combustible cigarettes.ConclusionThe exposure to primary and second-hand e-cigarette aerosol is related to higher metal concentrations in the biological samples. The adverse effects of this exposure on long-term users are yet to be determined.
Feature elimination and stacking framework for accurate heart disease detection in IoT healthcare systems using clinical data
Authors: Jian Wang , Li Jian Ping , Haq Amin Ul , Khan Shakir , Alotaibi Reemiah Muneer , Alajlan Saad Abdullah , Heyat Md Belal Bin 
Published: May 2024

IntroductionHeart disease remains a complex and critical health issue, necessitating accurate and timely detection methods.MethodsIn this research, we present an advanced machine learning system designed for efficient and precise diagnosis of cardiac disease. Our approach integrates the power of Random Forest and Ada Boost classifiers, along with incorporating data pre-processing techniques such as standard scaling and Recursive Feature Elimination (RFE) for feature selection. By leveraging the ensemble learning technique of stacking, we enhance the model's predictive performance by combining the strengths of multiple classifiers.ResultsThe evaluation metrics results demonstrate the superior accuracy and obtained the higher performance in terms of accuracy, 99.25%. The effectiveness of our proposed system compared to baseline models.DiscussionFurthermore, the utilization of this system within IoT-enabled healthcare systems shows promising potential for improving heart disease diagnosis and ultimately enhancing patient outcomes.
A decade of insight: bibliometric analysis of gut microbiota’s role in osteoporosis (2014–2024)
Authors: Luo Zhi Qiang , Huang Ya Jing , Chen Ze Hua , Lu Chen Yin , Zhou Biao , Gong Xiang Hao , Shen Zhen , Wang Tao 
Published: May 2024

PurposeOsteoporosis represents a profound challenge to public health, underscoring the critical need to dissect its complex etiology and identify viable targets for intervention. Within this context, the gut microbiota has emerged as a focal point of research due to its profound influence on bone metabolism. Despite this growing interest, the literature has yet to see a bibliometric study addressing the gut microbiota’s contribution to both the development and management of osteoporosis. This study aims to fill this gap through an exhaustive bibliometric analysis. Our objective is to uncover current research hotspots, delineate key themes, and identify future research trends. In doing so, we hope to provide direction for future studies and the development of innovative treatment methods.MethodsRelevant publications in this field were retrieved from the Web of Science Core Collection database. We used VOSviewer, CiteSpace, an online analysis platform and the R package “Bibliometrix” for bibliometric analysis.ResultsA total of 529 publications (including 351 articles and 178 reviews) from 61 countries, 881 institutions, were included in this study. China leads in publication volume and boast the highest cumulative citation. Shanghai Jiao Tong University and Southern Medical University are the leading research institutions in this field. Nutrients contributed the largest number of articles, and J Bone Miner Res is the most co-cited journal. Of the 3,166 scholars who participated in the study, Ohlsson C had the largest number of articles. Li YJ is the most co-cited author. “Probiotics” and “inflammation” are the keywords in the research.ConclusionThis is the first bibliometric analysis of gut microbiota in osteoporosis. We explored current research status in recent years and identified frontiers and hot spots in this research field. We investigate the impact of gut microbiome dysregulation and its associated inflammation on OP progression, a topic that has garnered international research interest in recent years. Additionally, our study delves into the potential of fecal microbiota transplantation or specific dietary interventions as promising avenues for future research, which can provide reference for the researchers who focus on this research filed.
Assessment of the relationship between gut microbiota and bone mineral density: a two-sample Mendelian randomization study
Authors: Xue Yuan , Wang Xuan , Liu Honglin , Kang Junfeng , Liang Xiaohong , Yao Aina , Dou Zhifang 
Published: May 2024

BackgroundEmerging evidence from observational studies and clinical trials suggests a connection between the gut microbiota and variations in bone mineral density (BMD). Nonetheless, the specific association between gut microbiota and BMD alterations at different skeletal sites has not been comprehensively explored. To address this, we employed Genome-Wide Association Study (GWAS) summary statistics from a publicly accessible database, conducting a two-sample Mendelian Randomization analysis to elucidate the potential causal relationship between gut microbiota composition and BMD.MethodsThis study utilized two distinct thresholds for screening instrumental variables (IVs), followed by an extensive series of quality control procedures to identify IVs that were significantly related to exposure. Gut microbiota were classified into two sets based on hierarchical levels: phylum, class, order, family, and genus. Bone mineral density (BMD) data were systematically collected from four skeletal sites: femoral neck, lumbar spine, forearm, and heel. For Mendelian Randomization (MR) analysis, robust methods including Inverse-Variance Weighting (IVW) and the Wald Ratio Test were employed. Additional analytical tests such as the Outlier Test, Heterogeneity Test, ‘Leave-One-Out’ Test, and Pleiotropy Test were conducted to assess the impact of horizontal pleiotropy, heterogeneities, and the genetic variation stability of gut microbiota on BMD causal associations. The MR Steiger Directionality Test was applied to exclude studies with potential directional biases.ResultsIn this two-sample Mendelian randomization analysis, we utilized five sets of exposure GWAS (Genome-Wide Association Studies) summary statistics and four sets of outcome GWAS summary statistics. The initial analysis, applying a threshold of p &lt; 5 × 10−6, identified 48 significant causal relationships between genetic liability in the gut microbiome and bone mineral density (BMD). A subsequent analysis with a more stringent threshold of p &lt; 5 × 10−8 uncovered 14 additional causal relationships. Upon applying the Bonferroni correction, 9 results from the first analysis and 10 from the second remained statistically significant.ConclusionOur MR analysis revealed a causal relationship between gut microbiota and bone mineral density at all sites, which could lead to discoveries in future mechanistic and clinical studies of microbiota-associated osteoporosis.