bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pulmonary Capillary Blood Flow and Cardiac Output Measurement by Partial Carbon Dioxide Rebreathing in Patients with Acute Respiratory Distress Syndrome Receiving Lung Protective Ventilation
Authors: Allardet-Servent Jérôme , Forel Jean-Marie , Roch Antoine , Chiche Laurent , Guervilly Christophe , Bouzana Fouad , Vincent Agnès , Gainnier Marc , Loundou Anderson , Papazian Laurent 
Published: October 2009

Background
Partial carbon dioxide rebreathing noninvasively measures the pulmonary capillary blood flow and estimates the cardiac output with the use of a predicted shunt value. It has been reported that the accuracy of the method is decreased in patients with high pulmonary shunt. The aim of this study was to investigate the agreement between partial rebreathing and thermodilution for the determination of pulmonary capillary blood flow and cardiac output in the setting of acute respiratory distress syndrome.

Methods
Twenty consecutive patients with the acute respiratory distress syndrome were enrolled. Ventilator settings include low tidal volume (6 ml x kg(-1)) and positive end-expiratory pressure + 2 cm H2O higher than the lower inflection point if present or 10 cm H2O if not. Seven pairs of cardiac output and pulmonary capillary blood flows were recorded every 20 min over a 2-h period. The authors determined bias, SD, limit of agreement (95% confidence interval) and percentage error.

Results
Bias and agreement for cardiac output measurement were 0.8 +/- 1.2 l x min(-1) (-2.1 to 3.7 l x min(-1)), and percentage error was 36%. Bias and agreement for pulmonary capillary blood flow measurement were -0.1 +/- 0.8 l x min(-1) (-2.1 to 1.9 l x min(-1)), and percentage error was 35%. Dead space, arteriovenous oxygen content difference, mean pulmonary arterial pressure, and baseline cardiac output were independently associated with differences between methods.

Conclusions
In patients with the acute respiratory distress syndrome, partial rebreathing cannot yet replace thermodilution for measuring pulmonary capillary blood flow or cardiac output. However, accuracy of the method is close to the boundary of clinical relevance.
Mathematical Modeling of the Pain and Progress of the First Stage of Nulliparous Labor
Authors: Debiec Jozef , Conell-Price Jessamyn , Evansmith Jennifer , Shafer Steven L. , Flood Pamela 
Published: October 2009

Background
Patient characteristics may contribute to the progress and pain of labor. Quantitative evaluation of the effects of patient characteristics requires robust mathematical models of labor progress and labor pain.

Methods
The authors retrospectively studied 100 sequential deliveries from each of five self-reported ethnic groups (Asian, Black, Hispanic, Other, and White). Demographic variables, cervical dilation, and numerical rating scores for pain before analgesia and cervical dilation were abstracted from the automated medical record. Labor progress was modeled with a biexponential function describing the latent and active phases of labor. Labor pain was modeled as a sigmoid function of cervical dilation by using a previously validated mathematical model. The covariates, including self-described ethnicity, were analyzed with NONMEM.

Results
The biexponential function described the time course of labor progress better than several alternative functions, including the sigmoidal function introduced by Friedman. The sigmoidal function of labor pain described its dynamic nature well, with substantial intersubject variability. Asian women had slower active labor than other ethnicities (P < 0.01). Asian women also reported less pain during their labor compared to all other patients (P < 0.001). Slower labor progress was associated with less rapid progression of pain, but this did not obviate the effect of Asian ethnicity on pain. Neuraxial analgesia is strongly associated with slower labor (P < 0.0001). Greater maternal weight was associated with slower active labor (P < 0.0001).

Conclusions
Mathematical models can be used to detect subtle effects of patient covariates on the progress and pain of the first stage of labor. Asian women and heavier women had slower labor and slower onset of labor pain than others. These effects were modest compared with the substantial remaining unexplained subject-to-subject variability in labor progress and labor pain.
Differences in Quantitative Architecture of Sciatic Nerve May Explain Differences in Potential Vulnerability to Nerve Injury, Onset Time, and Minimum Effective Anesthetic Volume
Authors: Moayeri Nizar , Groen Gerbrand J. 
Published: October 2009

Background
In sciatic nerve (SN) blocks, differences are seen in risk of nerve damage, minimum effective anesthetic volume, and onset time. This might be related to differences in the ratio neural:nonneural tissue within the nerve. For the brachial plexus, a higher proximal ratio may explain the higher risk for neural injury in proximal nerve blocks. A similar trend in risk is reported for SN; however, equivalent quantitative data are lacking. The authors aimed to determine the ratio neural:nonneural tissue within SN in situ in the upper leg.

Methods
From five consecutive cadavers, the region between the sacrum and distal femur condyle was harvested and frozen. Using a cryomicrotome, consecutive transversal sections (interval, 78 mum) were obtained and photographed. Reconstructions of SN were made strictly perpendicular to its long axis in the midgluteal, subgluteal, midfemoral, and popliteal regions. The epineurial area and all neural fascicles were delineated and measured. The nonneural tissue compartment inside and outside SN was also delineated and measured.

Results
The amount of neural tissue inside the epineurium decreased significantly toward distal (midfemoral/popliteal region) (P < 0.001). The relative percentage of neural tissue decreased from midgluteal (67 +/- 7%), to subgluteal (57 +/- 9%), to midfemoral (46 +/- 10%), to popliteal (46 +/- 11%). Outside the SN, the adipose compartment increased significantly toward distal (P < 0.007).

Conclusion
In SN, the ratio neural:nonneural tissue changes significantly from 2:1 (midgluteal and subgluteal) to 1:1 (midfemoral and popliteal). This suggests a higher vulnerability for neurologic sequelae in proximal SN, and may explain differences observed in minimum effective anesthetic volume and onset time between proximal and distal SN blocks.
Mechanisms of Impaired Glucose Tolerance and Insulin Secretion during Isoflurane Anesthesia
Authors: Tanaka Katsuya , Kawano Takashi , Tomino Takehito , Kawano Hiroaki , Okada Tsuyoshi , Oshita Shuzo , Takahashi Akira , Nakaya Yutaka 
Published: October 2009

Background
Volatile anesthetics impair insulin secretion and glucose utilization; however, the precise mechanism of action that underlies these effects is unknown. The authors hypothesized that isoflurane inhibits glucose-induced inhibition of adenosine triphosphate-sensitive potassium channel activity in pancreatic beta cells, which could result in impaired insulin secretion and glucose tolerance.

Methods
Intravenous glucose tolerance tests were performed on 28 male Japanese White rabbits anesthetized with sodium pentobarbital. Glibenclamide (50 microg/kg + 33.5 microg x kg x h) or vehicle was administered 75 min before intravenous administration of 0.6 g/kg glucose. Half of the animals (n = 7) in the vehicle and glibenclamide groups received isoflurane at 1.0 minimum alveolar concentration 30 min before administration of glucose, and the other half received a vehicle control. Hemodynamics, blood glucose, and plasma insulin were measured. A cell-attached patch clamp configuration was used to record single channel currents in the pancreas from male Swiss-Webster mice.

Results
Isoflurane alone or a combination of isoflurane and glibenclamide inhibited the insulinogenic index to a greater extent than in the vehicle and glibenclamide groups. In the patch clamp experiments, channel activity was significantly decreased as the glucose concentration was increased from 0 to 10 mm. The subsequent application of 0.5 mm isoflurane reversed the effects of glucose on channel activity.

Conclusion
These results show that isoflurane impairs insulin secretion and glucose utilization. The mechanism of action responsible for these effects may involve a decrease in glucose-induced inhibition of adenosine triphosphate-sensitive potassium channel activity in pancreatic beta cells.
Perineural Dexmedetomidine Added to Ropivacaine Causes a Dose-dependent Increase in the Duration of Thermal Antinociception in Sciatic Nerve Block in Rat
Authors: Brummett Chad M. , Padda Amrita K. , Amodeo Francesco S. , Welch Kathleen B. , Lydic Ralph 
Published: October 2009

Background
The current study was designed to test the hypothesis that dexmedetomidine added to ropivacaine would increase the duration of antinociception to a thermal stimulus in a dose-dependent fashion in a rat model of sciatic nerve blockade.

Methods
Fifty adult Sprague-Dawley rats (10 rats/group) received unilateral sciatic nerve blocks with 0.2 ml ropivacaine (0.5%) or 0.2 ml ropivacaine (0.5%) plus dexmedetomidine (2.7 microm [0.5 microg/kg], 11.7 microm [2 microg/kg], 34.1 microm [6 microg/kg], or 120.6 microm [20 microg/kg]) in a randomized, blinded fashion. Time to paw withdrawal latency to a thermal stimulus for both paws and an assessment of motor function were measured every 30 min after the nerve block until a return to baseline.

Results
Dexmedetomidine added to ropivacaine increased the duration of dense sensory blockade and time for return to normal sensory function in a dose-dependent fashion (P < 0.005). There was a significant time (P < 0.005), dose (P < 0.005), and time-by-dose effect (P < 0.005) on paw withdrawal latencies of the operative paws. There were no significant differences in paw withdrawal latencies of the control paws, indicating little systemic effect of the dexmedetomidine. The duration of motor blockade was also increased with dexmedetomidine. High-dose dexmedetomidine (120.6 mum) was not neurotoxic.

Conclusion
This is the first study showing that dexmedetomidine added to ropivacaine increases the duration of sensory blockade in a dose-dependent fashion in rats. The findings are an essential first step encouraging future efficacy studies in humans.
Genetic structure of Eurasian cattle (Bos taurus) based on microsatellites: clarification for their breed classification1
Authors: Li M.‐H. , Kantanen J. 
Published: October 2009

SummaryWe pool three previously published data sets and present population genetic analyses of microsatellite variation in 48 Bos taurus cattle breeds from a wide range of geographical origins in Eurasia, mostly its northern territory. Bayesian model‐based clustering reveals six distinct clusters: besides a single‐population cluster of the Yakutian Cattle from Far Eastern Siberia and a cluster of breeds characteristic of an early origin, the other four major clusters largely correspond to previously defined morphological subgroups of Red Lowland, Lowland Black‐Pied, Longhorned Dairy and North European Polled cattle breeds. The results highlighted past expansion events of the productive breeds such as Danish Red, Angeln, Holstein‐Friesian and Ayrshire in northern and Eastern Europe. Based on genetic assignment of the breeds and the availability of breed information, we provide a preliminary classification of the five breeds that were to date undefined. Furthermore, in the analysis of molecular variance, despite some correspondence between geographical proximity and genetic similarity, the breed classification appears to be a better predictor of genetic structure in the cattle populations (the among‐group variance component: breed classification, 2.47%, P < 0.001; geographical division, 0.77%, P < 0.001).
Emplacement mechanics of sandstone intrusions: insights from the Panoche Giant Injection Complex, California
Authors: Vétel W. , Cartwright J. 
Published: October 2009

ABSTRACTThe Panoche Giant Injection Complex (PGIC; California) constitutes the most complete sandstone intrusion network yet described, and is an excellent analogue for subsurface hydrocarbon reservoirs modified by sand remobilisation. Sandstone dykes and sills were intruded during the Late Palaeocene into slope mudstones of the Great Valley forearc basin, and are exposed for more than 300 km2. The PGIC consists of dykes and sills and represents upwards infilling of natural hydraulic fractures sourced from highly overpressured Cretaceous sand bodies. Over 1300 orientation measurements show that dykes are almost randomly oriented with only a slight orientation bias trending NE–SW, N–S or NW–SE, suggesting either a horizontally isotropic state of stress during intrusion or modification of stress by newly‐formed fractures that override the remote stress. Dykes are segmented in a pattern consistent with radial propagation with fingering towards tips similar to that observed for other mixed mode fractures. Kinematic indicators reveal there was no systematic sense of opening for the intrusions. This is interpreted as the result of short‐range mechanical interactions. Cross‐cutting relationships between injections imply a diachronous timing and a fluid pressure in the source units that was in excess of the lithostatic load. Finally we document a suite of minor structures within the host section that allowed the strain of the forcefully intruded sand to be accommodated.
Identification of Aspergillus tubingensis strains responsible for OTA contamination in grapes and wine based on the acyl transferase domain of a polyketide synthase gene
Authors: López‐Mendoza María Carmen , Crespo‐Sempere Ana , Martínez‐Culebras Pedro Vicente 
Published: October 2009

SummaryRestriction digestion analysis of the acyl transferase (AT) domain sequences of a polyketide synthase (PKS) gene was tested as a rapid method to identify isolates of Aspergillus tubingensis from grapes. Restriction endonuclease digestion of PKS products using the endonucleases BccI, HaeIII, HpaII, MboI and TaqI distinguished five types of restriction fragment length polymorphism (RFLP). Ochratoxigenic isolates were only identified within RFLP‐types I and III. The RFLP assay is proposed as a rapid and easy method to identify A. tubingensis isolates from grapes. Amino acid sequences of AT domains from representative A. tubingensis isolates of the RFLP types obtained were aligned and analysed using phylogenetic methods. A comparison was also made with reference strains of Aspergillus section Nigri. Most of the A. tubingensis strains clustered into two distinct groups Gr1 and Gr2 with the exception of two isolates that remained unclustered. These results support the intraspeficific variability within A. tubingensis species reported using other techniques.
Development of a simple model based on chemical kinetics parameters for predicting respiration rate of carambola fruit
Authors: Duan Hua‐Wei , Wang Zhi‐Wei , Hu Chang‐Ying 
Published: October 2009

SummaryThe respiration model was parameterised with experimental data obtained at temperatures 10, 15, 20, 25 and 30 °C by the closed system. Reaction orders of O2 and CO2 determined for respiration rate are 0.912 and −0.24, respectively. Estimates of A and Ea for rate coefficient are 5.219 × 1010 h−1 and 61.397 kJ mol−1, respectively. The reliability of the model was verified against new data generated from 18 °C. An enzyme kinetics based model was likewise built and verified as a contrast. Verification results indicate that the chemical kinetics model performs very well and has superiority over the enzyme kinetics one. This study demonstrates that chemical kinetics can be used to underpin the development of simple respiration model and should facilitate the prediction of respiration rate for the carambola fruit in practice.
Four‐locus high‐resolution HLA typing in a sample of Mexican Americans
Authors: Klitz W. , Gragert L. , Maiers M. , Tu B. , Lazaro A. , Yang R. , Xu Q. , Masaberg C. , Ng J. , Hurley C. K. 
Published: October 2009

AbstractMexicans are the most common minority population of the United States. From a sample of 553 bone marrow donor registrants of self‐described Mexican ancestry, human leukocyte antigen (HLA) loci A, C, B and DRB1 were typed by highresolution sequence based typing (SBT) methods. A total of 47, 34, 76 and 46 distinct alleles at A, C, B and DRB1 respectively were identified, including 3 new alleles. The four‐locus haplotype frequency distribution was extremely skewed with only 53.9% of 1106 chromosomes present with more than one estimated copy. Haplotypes of Native American origin were identified. These data form an initial basis for determining the requirements for an adequate donor pool for stem cell transplantation in this population.
Soil conservation in Polylepis mountain forests of Central Argentina: Is livestock reducing our natural capital?
Authors: RENISON DANIEL , HENSEN ISABELL , SUAREZ RICARDO , CINGOLANI ANA M. , MARCORA PAULA , GIORGIS MELISA A. 
Published: October 2009

AbstractMountain forests and their soils provide ecological services such as maintenance of biodiversity, provision of clean water, carbon capture and forage for livestock rearing, which is one of the principal economic activities in mountain areas. However, surprisingly little is known about livestock impact in South American mountain forest soils. With the aim of understanding how livestock and topography influence patterns of forest cover, soil compaction, soil loss and soil chemical properties, we analysed these parameters in 100 Polylepis australis woodland plots situated in the humid subtropical mountains of Central Argentina. We used distance from the nearest ranch as an objective index of historical livestock impact and measured standard topographic variables. Our main results reveal that distance from ranch in all cases partly explains tree canopy cover, soil loss, soil compaction and soil chemical properties; suggesting a strong negative effect of livestock. Intermediate altitudes had more tree canopy cover, while landscape roughness – a measure of the variability in slope inclination and aspect – was negatively associated to soil impedance and acidity, and positively associated to soil organic matter content. Finally, flatter areas were more acid. We conclude that livestock has had a substantial influence on forest soil degradation in the Mountains of Central Argentina and possibly other similar South American mountains. Soil degradation should be incorporated into decision making when considering long‐term forest sustainability, or when taking into account retaining livestock for biodiversity conservation reasons. Where soil loss and degradation are ongoing, we recommend drastic reductions in livestock density.
Exploring the Moderating Roles of Perceived Person–Job Fit and Person–Organisation Fit on the Relationship between Training Investment and Knowledge Workers' Turnover Intentions
Authors: Chang Huo‐Tsan , Chi Nai‐Wen , Chuang Aichia 
Published: October 2009

Previous studies have documented inconsistent results in terms of the relationship between knowledge workers' perceived training investment and their turnover intentions. In order to clarify the inconsistencies, the present study extends previous research by exploring the moderating roles of perceived demand–ability (D–A) job fit and person–organisation (P–O) fit. Data were collected from 303 research and development (R&D) engineers from 30 high‐technology firms in Taiwan. Hierarchical regression analyses were conducted to test the hypotheses. The results show that perceived D–A fit, P–O fit, and perceived training investment interact jointly to predict knowledge workers' turnover intentions. Specifically, while the main effect of perceived training investment on turnover intentions was negative, under situations of extremely high perceived D–A fit and extremely low P–O fit, the relationship between knowledge workers' perceived training investment and their turnover intentions became positive, and under situations of low perceived D–A fit and high P–O fit, the relationship between knowledge workers' perceived training investment and their turnover intentions remained negative. Theoretical and practical implications are also discussed.Les études antérieures ont donné des résultats contradictoires quant aux relations entre la connaissance que les salariés perçoivent de l’investissement dans la formation et leurs intentions de changer. Dans le but de clarifier ces incohérences, la présente étude prend la suite de recherches antérieures en explorant les rôles modérateurs de la compatibilité perçue entre la compétence et les nécessités au travail (DA) et de la compatibilité entre la personne prise dans sa globalité et les caractéristiques de l’organisation qui l’emploie (PO). Les données ont été collectées auprès de 303 ingénieurs en recherche et développement (R&D) de 30 entreprises de haute technologie à Taiwan. Des analyses de régression hiérarchique ont conduit à tester les hypothèses. Les résultats montrent que la compatibilité D‐A, la compatibilité P‐O et l’investissement perçu dans la formation interagissent conjointement pour prédire les intentions de changement des employés. Plus spécifiquement, alors que le principal effet de l’investissement perçu dans la formation sur les intentions de changement est négatif, dans des conditions de compatibilité D‐A perçue comme étant basse et de compatibilité P‐O haute, la relation entre la connaissance que les salariés perçoivent de l’investissement dans la formation et leurs intentions de changement reste négative. Les implications théoriques et pratiques sont aussi discutées.
Interaction of size, book‐to‐market and momentum effects in Australia
Authors: O’Brien Michael A. , Brailsford Tim , Gaunt Clive 
Published: October 2009

AbstractThis study seeks to disentangle the effects of size, book‐to‐market and momentum on returns. Initial results show that each characteristic has a role in explaining returns, but that there is interaction between size and momentum, as well as between size and book‐to‐market. Three key findings emerge. First, the size premium is the strongest, particularly in the loser portfolios. Second, the value premium is generally limited to the smallest portfolios. Third, the momentum premium is evident for the large‐ and middle‐sized portfolios, but loser stocks significantly outperform winner stocks in the smallest size portfolio. When these interactions are controlled with multivariate regression, we find a significant negative average relation between size and returns, a significant positive average relation between book‐to‐market and returns, and a significant positive average relation between momentum and returns.