bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Potent Vaccination Strategy That Circumvents Lymphodepletion for Effective Antitumor Adoptive T-cell Therapy
Authors: Cho Hyun-Il , Reyes-Vargas Eduardo , Delgado Julio C. , Celis Esteban 
Published: February 2012

AbstractAdoptive cell therapy using tumor-reactive T lymphocytes is a promising approach for treating advanced cancer. Successful tumor eradication depends primarily on the expansion and survival of the adoptively transferred T cells. Lymphodepletion using total body irradiation (TBI) and administering high-dose interleukin (IL)-2 have been used with adoptive cell therapy to promote T-cell expansion and survival to achieve maximal therapeutic effects. However, TBI and high-dose IL-2 increase the risk for major complications that impact overall survival. Here we describe an alternative approach to TBI and high-dose IL-2 for optimizing adoptive cell therapy, resulting in dramatic therapeutic effects against established melanomas in mice. Administration of a potent, noninfectious peptide vaccine after adoptive cell therapy dramatically increased antigen-specific T-cell numbers leading to enhancement in the survival of melanoma-bearing mice. Furthermore, combinations of peptide vaccination with PD1 blockade or IL-2/anti-IL-2 antibody complexes led to complete disease eradication and long-term survival in mice with large tumors receiving adoptive cell therapy. Our results indicate that PD1 blockade and IL-2/anti-IL-2 complexes enhance both the quantitative and qualitative aspects of the T-cell responses induced by peptide vaccination after adoptive cell therapy. These findings could be useful for the optimization of adoptive cell therapy in cancer patients without the need of toxic adjunct procedures. Cancer Res; 72(8); 1986–95. ©2012 AACR.
Molecular Pathways: Digoxin Use and Estrogen-Sensitive Cancers—Risks and Possible Therapeutic Implications
Authors: Biggar Robert J. 
Published: February 2012

AbstractDigoxin, a phyto-estrogen, binds with estrogen receptors (ER) and can cause gynecomastia. Among women currently using digoxin, breast and uterus cancer incidences are significantly increased (approximate risk ratios, 1.3–1.5). Both cancers are often estrogen sensitive. In contrast, ovary and cervix cancers are relatively estrogen insensitive, and incidence is unaffected by digoxin exposure. When digoxin use stops, incidence rapidly reverts to that in nonusers. These patterns parallel those of estrogen, suggesting that digoxin works via ER-stimulated proliferation of ductal and/or acinar cells, accelerating the growth of nascent cancers. Also consistent with an estrogenic effect, men using digoxin have a small but significant reduction in prostate cancer (risk ratio, 0.76). Other estrogen-like drugs, particularly spironolactone, should be investigated for similar effects. The effect of digoxin use in women being treated for breast cancer or in survivors is unknown. Women with estrogen-sensitive cancers on adjuvant therapy may take tamoxifen, which blocks ERs. However, postmenopausal patients may use aromatase inhibitors, which block estrogen production while leaving ERs susceptible to digoxin. If adverse effects are found, tamoxifen may be preferred over aromatase inhibitors in patients receiving estrogen-mimicking drugs. Alternatively, other cardiotropic drugs might be considered in women with or at high risk of developing estrogen-sensitive cancers. Clin Cancer Res; 18(8); 2133–7. ©2012 AACR.
Feasibility of Dual Wireless Esophageal pH Monitoring
Authors: Francis David O. , Sumner Eric , Goutte Marion , Slaughter James C. , Garrett C. Gaelyn , Hagaman David , Vaezi Michael F. 
Published: February 2012

ObjectiveWireless pH monitoring is currently employed in the distal esophagus. There are no controlled studies on the feasibility/safety of proximal esophageal wireless pH capsule placement. We tested the hypothesis that there will be no difference in patient perception of a more proximally placed pH capsule.Study DesignRandomized single‐blinded sham‐controlled trial.SettingTertiary care center.Subjects and MethodsAll patients had a wireless pH capsule positioned 6 cm proximal to the gastroesophageal junction. They were randomized into intervention or sham groups after distal capsule placement. The delivery introducer was positioned 10 cm proximal to the distal esophageal capsule, and a second capsule was either deployed (intervention) or not (sham) based on group allocation. Patients were blinded to group assignment. Modified Edmonton Score was used to assess for chest pain, dysphagia, and odynophagia. The primary endpoints were (1) required endoscopic removal because of discomfort and (2) change in chest pain scores, controlling for baseline pain.ResultsPatients were randomized to either the intervention, proximal esophageal capsule (n = 11), or sham (n = 11). Patients with proximal pH probes had higher odds of having their chest pain (odds ratio [OR], 8.44; 95% confidence interval [CI], 1.35‐52.6; P =. 02), odynophagia (OR, 49.5; 95% CI, 4.70‐520; P =. 001), and dysphagia (OR, 14.3; 95% CI, 2.12‐96.6; P =. 006) exacerbated. Two (2/11; 18%) proximally deployed probes required endoscopic removal because of patient intolerance or discomfort.ConclusionA proximal esophageal wireless pH monitor placement is feasible but results in increased chest pain, odynophagia, and dysphagia that can be severe enough to require endoscopic removal. These limitations preclude its potential clinical benefit.
Management of Dysphonic Patients by Otolaryngologists
Authors: Cohen Seth M. , Pitman Michael J. , Noordzij J. Pieter , Courey Mark 
Published: February 2012

ObjectiveTo investigate common treatment approaches of general otolaryngologists for adult dysphonic patients without obvious laryngeal anatomic abnormalities.Study DesignCross‐sectional survey.SettingGeneral otolaryngology community.Subjects and MethodsOne thousand randomly chosen American Academy of Otolaryngology—Head and Neck Surgery general otolaryngologists were mailed a survey.ResultsThe response rate was 27.8%. Mean years in practice was 19.5. The most common treatments were proton pump inhibitor (PPI), referral to speech pathology, and stroboscopy. Muscle tension dysphonia, vocal fold nodules, and dysphonia of uncertain etiology were the most common reasons for voice therapy referral. Various forms of supraglottic compression and tender extralaryngeal muscles were identified as findings of muscle tension dysphonia. Response to once‐daily PPI, laryngeal signs, and throat symptoms were the most common determinants for laryngopharyngeal reflux. When patients failed initial treatment, 58.2% refer for voice therapy, 46.9% obtain stroboscopy, and 33.3% extend or increase duration of PPI treatment.ConclusionsVaried treatment approaches to adult dysphonic patients were identified. How practice patterns vary from best practice guidelines, affect patient outcome, and influence health care costs needs examination.
Ramipril and Telmisartan Exhibit Differential Effects in Cardiac Pressure Overload-Induced Hypertrophy Without an Additional Benefit of the Combination of Both Drugs
Authors: Müller Patrick , Kazakov Andrey , Semenov Alexander , Jagoda Philippe , Friedrich Erik B. , Böhm Michael , Laufs Ulrich 
Published: February 2012

Objectives: We aimed to characterize different cellular effects of angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin 1 (AT1) receptor blockers (ARBs) as mono- or combination therapy in cardiac pressure overload. Methods and Results: C57B1/6 mice received either the ACEI ramipril (2.5 mg/kg body weight), the ARB telmisartan (20 mg/kg body weight), or the combination. In all groups, pressure overload was induced by transverse aortic constriction (TAC). Cardiac hypertrophy (heart weight/tibia length) induced by TAC was reduced in all 3 treatment groups, with the most pronounced effect in the telmisartan group. The cardiomyocyte short-axis diameter and cardiac fibrosis were increased by TAC and similarly reduced by ACEI, ARB, and the combination therapy. The TAC-induced increase in the number of proliferating Ki67pos cardiomyocytes and noncardiomyocytes was reduced more potently by ACEI than by ARB. Four days of drug treatment induced a significant increase in Scalpos/VEGFR1pos endothelial progenitor cells (EPCs) in all animals in the treated SHAM groups. After 1 day of aortic constriction, only ramipril increased EPC numbers; after 5 weeks, telmisartan monotherapy did not change the EPC levels compared to vehicle or the combination therapy but raised it compared to ramipril. Neither TAC nor one of the therapies changed the number of cardiac capillaries per cardiomyocytes. Conclusions: ACE inhibition and AT1 receptor blockade have beneficial effects in remodeling processes during cardiac pressure overload. There are small differences between the 2 therapeutical approaches, but the combination therapy has no additional benefit.
NOD/scid IL-2Rgnull mice: a preclinical model system to evaluate human dendritic cell-based vaccine strategies in vivo
Authors: Spranger Stefani , Frankenberger Bernhard , Schendel Dolores J 
Published: February 2012

Abstract

Background
To date very few systems have been described for preclinical investigations of human cellular therapeutics in vivo. However, the ability to carry out comparisons of new cellular vaccines in vivo would be of substantial interest for design of clinical studies. Here we describe a humanized mouse model to assess the efficacy of various human dendritic cell (DC) preparations. Two reconstitution regimes of NOD/scid IL2Rgnull (NSG) mice with adult human peripheral blood mononuclear cells (PBMC) were evaluated for engraftment using 4-week and 9-week schedules. This led to selection of a simple and rapid protocol for engraftment and vaccine evaluation that encompassed 4 weeks.

Methods
NSG recipients of human PBMC were engrafted over 14 days and then vaccinated twice with autologous DC via intravenous injection. Three DC vaccine formulations were compared that varied generation time in vitro (3 days versus 7 days) and signals for maturation (with or without Toll-like receptor (TLR)3 and TLR7/8 agonists) using MART-1 as a surrogate antigen, by electroporating mature DC with in vitro transcribed RNA encoding full length protein. After two weekly vaccinations, the splenocyte populations containing human lymphocytes were recovered 7 days later and assessed for MART-1-specific immune responses using MHC-multimer-binding assays and functional assessment of specific killing of melanoma tumor cell lines.

Results
Human monocyte-derived DC generated in vitro in 3 days induced better MART-1-specific immune responses in the autologous donor T cells present in the humanized NSG mice. Moreover, consistent with our in vitro observations, vaccination using mature DC activated with TLR3 and TLR7/8 agonists resulted in enhanced immune responses in vivo. These findings led to a ranking of the DC vaccine effects in vivo that reflected the hierarchy previously found for these mature DC variations in vitro.

Conclusions
This humanized mouse model system enables comparisons among different DC vaccine types to be rapidly assessed in vivo. In addition, ex vivo analyses of human CD3+ T cells recovered from the spleens of these mice are also possible, including studies on lymphocyte subsets, Th1/Th2 polarization, presence of regulatory T cells and the impact of DC vaccination on their functions.
Cauchy problem for a class of parabolic systems of Shilov type with variable coefficients
Authors: Litovchenko Vladyslav , Dovzhytska Iryna 
Published: February 2012

Abstract
In the case of initial data belonging to a wide class of functions including distributions of Gelfand-Shilov type we establish the correct solvability of the Cauchy problem for a new class of Shilov parabolic systems of equations with partial derivatives with bounded smooth variable lower coefficients and nonnegative genus. We also investigate the conditions of local improvement of the convergence of a solution of this problem to its limiting value when the time variable tends to zero.
Nonextensive statistical effects in the quark-gluon plasma formation at relativistic heavy-ion collisions energies
Authors: Gervino Gianpiero , Lavagno Andrea , Pigato Daniele 
Published: February 2012

AbstractWe investigate the relativistic equation of state of hadronic matter and quark-gluon plasma at finite temperature and baryon density in the framework of the non-extensive statistical mechanics, characterized by power-law quantum distributions. We impose the Gibbs conditions on the global conservation of baryon number, electric charge and strangeness number. For the hadronic phase, we study an extended relativistic mean-field theoretical model with the inclusion of strange particles (hyperons and mesons). For the quark sector, we employ an extended MIT-Bag model. In this context we focus on the relevance of non-extensive effects in the presence of strange matter.
A generic 3D kinetic model of gene expression
Authors: Zhdanov Vladimir 
Published: February 2012

Abstract
Recent experiments show that mRNAs and proteins can be localized both in prokaryotic and eukaryotic cells. To describe such situations, I present a 3D mean-field kinetic model aimed primarily at gene expression in prokaryotic cells, including the formation of mRNA, its translation into protein, and slow diffusion of these species. Under steady-state conditions, the mRNA and protein spatial distribution is described by simple exponential functions. The protein concentration near the gene transcribed into mRNA is shown to depend on the protein and mRNA diffusion coefficients and degradation rate constants.
A New Species of Mites of the Genus Anystipalpus (Mesostigmata, Ascidae) from the Eastern Ukraine
Authors: Trach V. 
Published: February 2012

A New Species of Mites of the Genus Anystipalpus (Mesostigmata, Ascidae) from the Eastern Ukraine
Anystipalpus stepposus Trach, sp. n. from Lugansk Region associated with carabid beetles is described. The new species is similar to A. livshitsi (Eidelberg, 1989), differing by the arrangement of short and thickened setae on the podonotal shield, presence of large presternal shields, shape and sclerotization of the sternal shield, shape of some setae on legs and venter of idiosoma, details of structure of the chelicerae.
Cloninger's Psychobiological Model of Personality and Strelau's Regulative Theory of Temperament - analysis of their associations in a Polish sample
Authors: Hornowska Elżbieta 
Published: February 2012

Cloninger's Psychobiological Model of Personality and Strelau's Regulative Theory of Temperament - analysis of their associations in a Polish sample
The present study explores the relationship between Cloninger scales and Strelau's Regulative Theory of Temperament (RTT) traits. Cloninger's psychobiological model identifies four dimensions of temperament (Novelty seeking, Harm Avoidance, Reward Dependence and Persistence) and three dimensions of character (Self-Directedness, Cooperativeness and Self-Transcendence). RTT proposes the traits of Briskness, Perseveration, Sensory Sensitivity, Emotional Reactivity, Endurance and Activity as the basic dimensions underlying individual differences. The relationships between the dimensions of Cloninger's Temperament and Character and Strelau's Regulative Theory of Temperament are investigated in a sample of 282 participants. Data analysis demonstrated some significant correlations between the two models. The strongest associations were found between the dimension of Harm Avoidance from Cloninger's concept and Strelau's RTT traits (positive correlations from r = .73 for Emotional Reactivity to r = .48 for Perseveration, and negative correlations from r = -.57 for Endurance to r = -.51 for Briskness). However, there is not enough evidence to suggest that the two models offer an alternative way of explaining individual differences. According to RTT, temperamental traits are expressed in formal characteristics of behavior (energetic and temporal) and every kind of behavior (irrespective of its content) can be described in the same formal categories. In the Psychobiological Model of Personality the traits are characterized rather by the content or goals of behavior. In this model, in addition to underlining the biological variation of heritable traits, the social, cultural and phenotypical levels of behavior are reflected.
La fabrique cinématographique de l'altérité. Les personnages de « Chinoises » dans le cinéma occidental
Authors: Staszak Jean-François 
Published: February 2012

L’article analyse le rôle du cinéma occidental dans la construction de l’altérité raciale et sexuelle, en suivant la carrière d’Anna May Wong, actrice hollywoodienne d’origine chinoise, active surtout dans les années 1920-1940. Il montre comment beaucoup de ses films portent sur le tabou des rapports interraciaux tout en érotisant son corps exotique. Ses personnages sont réduits à des stéréotypes, qui stigmatisent la communauté chinoise, en particulier aux États-Unis. Anna May Wong a été la victime d’un système raciste et sexiste qu’elle a malgré elle participé à reproduire. L’actrice est aujourd’hui célébrée par la communauté Chinese-American , mais a aussi acquis le statut d’icône gay du fait du caractère camp de ses personnages de Dragon Lady . Son parcours et ses films montrent que les systèmes de domination de genre et de race s’alimentent l’un autre, au point de les rendre indémêlables. Ces représentations de la femme orientale ont alimenté des phantasmes occidentaux, qui sont probablement impliqués dans le développement du tourisme sexuel en Asie du Sud-Est.
La néologie lexicale : de l'impasse à l'ouverture
Authors: Mortureux Marie-Françoise 
Published: February 2012

En 1974, dans Langages 36, L. Guilbert et son équipe signalaient les obstacles théoriques empêchant la syntaxe générative transformationnelle de N. Chomsky d’intégrer la néologie lexicale à la description linguistique. Divers travaux en morphologie lexicale et sémantique lexicale ont, depuis, éclairé la production et la lexicalisation des néologismes, inscrivant la néologie lexicale dans un modèle évolutionniste du lexique.
Du projet politique au projet syndical
Authors: Tonneau Jean-Philippe 
Published: February 2012

Résumé La « gauche judiciaire » initiée dans les années 1970 est bien souvent perçue a priori , car non analysée, comme l’œuvre de jeunes militants de l’extrême gauche qui, tout en débutant le deuil de leurs idéaux de jeunesse, pénètrent le monde professionnel. La création du Syndicat des avocats de France (SAF) en 1973 par des avocats communistes membres des cellules du Palais de Paris et de région parisienne oblige à rompre avec cette vision uniforme. Cet article s’intéresse aux deux premières générations du SAF : les fondateurs communistes et les avocats issus de l’extrême gauche adhérant dans la seconde moitié des années 1970. Après avoir mis en évidence les tensions entre ces générations d’avocats-militants aux affiliations et/ou orientations partisanes diverses, l’article montre comment la coexistence quotidienne dans la profession et dans le syndicat en phase d’établissement contribue à atténuer les tensions intergénérationnelles. Il met ce faisant en relief le poids des sociabilités et des contraintes professionnelles quotidiennes comme de la politique institutionnelle dans la dynamique des relations intergénérationnelles au sein d’un syndicat.
Quand une génération en cache une autre
Authors: Raison du Cleuziou Yann 
Published: February 2012

Résumé La crise que traverse le clergé catholique dans les années 1960-1970 a été interprétée comme la conséquence de la différenciation générationnelle des modes de socialisation à l’institution sacerdotale. Cet article revient sur cette interprétation et propose de penser le conflit de génération non seulement comme le produit d’une lutte d’habitus générationnels mais également comme une arène spécifique de lutte construite par des acteurs qui se réclament explicitement d’intérêts générationnels. En effet, une génération n’est pas que le produit d’un mode de socialisation spécifique, elle est également un groupe social construit à travers les discours et les pratiques d’acteurs qui se saisissent de cette catégorie d’identification à des fins mobilisatrices. À partir de l’exemple de la Province dominicaine de France, cet article montre comment se différencient les habitus des religieux au fil des années 1950-1960, puis comment l’Ordre va être mis en crise au nom des « jeunes » par une génération de dominicains qui accèdent aux positions dominantes et voient dans la contestation de mai 1968 une occasion d’imposer les réformes qu’ils souhaitent.
Les sens de l'humour
Authors: Zambiras Ariane 
Published: February 2012

Résumé L’approche ethnographique permet de saisir les discussions politiques informelles dont l’importance, pour l’étude de la politisation, a été soulignée. L’enquête présentée ici montre que l’humour est une modalité privilégiée de politisation des discussions informelles, en particulier dans un contexte public, car il permet d’atténuer les « logiques de conflictualisation » propres au processus de politisation. Introduire le politique sous forme de plaisanterie permet de proposer pour validation aux autres membres du groupe un contenu implicite, sans pour autant prendre le risque de clivage en cas de désaccord. L’échec de l’événement humoristique est une épreuve pour les participants à la discussion, mais celle-ci est moins profonde qu’un désaccord pleinement formulé lors d’une discussion de fond faisant apparaître des clivages insurmontables. Porter attention aux événements humoristiques permet de contribuer au renouvellement des modes d’approche de la politisation, et de comprendre comment celle-ci opère en dépit des risques de clivage qu’elle fait encourir à la communauté.
Limites du modèle délibératif : composer avec différents formats de participation
Authors: Richard-Ferroudji Audrey 
Published: February 2012

Résumé En France la politique de l’eau exige une participation des usagers à sa gestion et une concertation entre les différentes personnes concernées. Les critiques adressées aux dispositifs mis en œuvre pour remplir ces exigences montrent les limites d’une conception uniquement fondée sur le modèle délibératif et invitent à porter un regard attentif aux situations participatives. En nous appuyant sur la théorie des régimes d’engagement, nous proposons une grille de lecture de la manière dont les participants sont engagés et s’engagent dans les dispositifs selon différentes figures de participation : porteur d’enjeux, sujet politique et moral, personne enracinée ou être curieux. Cette approche est mobilisée pour décrire trois formats typiques de participation à la gestion de l’eau, en nous appuyant sur le cas du bassin de l’Orb. Cet article développe une critique interne des dispositifs pour penser leur ajustement. Il invite à penser l’articulation de différents formats de participation pour composer un dispositif approprié et qui reconnaisse les différences entre participants selon plusieurs dimensions.