bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of intensive lifestyle changes on the progression of mild cognitive impairment or early dementia due to Alzheimer’s disease: a randomized, controlled clinical trial
Authors: Ornish Dean , Madison Catherine , Kivipelto Miia , Kemp Colleen , McCulloch Charles E. , Galasko Douglas , Artz Jon , Rentz Dorene , Lin Jue , Norman Kim , Ornish Anne , Tranter Sarah , DeLamarter Nancy , Wingers Noel , Richling Carra , Kaddurah-Daouk Rima , Knight Rob , McDonald Daniel , Patel Lucas , Verdin Eric , E. Tanzi Rudolph , Arnold Steven E. 
Published: June 2024

Abstract
Background
Evidence links lifestyle factors with Alzheimer’s disease (AD). We report the first randomized, controlled clinical trial to determine if intensive lifestyle changes may beneficially affect the progression of mild cognitive impairment (MCI) or early dementia due to AD.

Methods
A 1:1 multicenter randomized controlled phase 2 trial, ages 45-90 with MCI or early dementia due to AD and a Montreal Cognitive Assessment (MoCA) score of 18 or higher. The primary outcome measures were changes in cognition and function tests: Clinical Global Impression of Change (CGIC), Alzheimer’s Disease Assessment Scale (ADAS-Cog), Clinical Dementia Rating–Sum of Boxes (CDR-SB), and Clinical Dementia Rating Global (CDR-G) after 20 weeks of an intensive multidomain lifestyle intervention compared to a wait-list usual care control group. ADAS-Cog, CDR-SB, and CDR-Global scales were compared using a Mann-Whitney-Wilcoxon rank-sum test, and CGIC was compared using Fisher’s exact test. Secondary outcomes included plasma Aβ42/40 ratio, other biomarkers, and correlating lifestyle with the degree of change in these measures.

Results
Fifty-one AD patients enrolled, mean age 73.5. No significant differences in any measures at baseline. Only two patients withdrew. All patients had plasma Aβ42/40 ratios <0.0672 at baseline, strongly supporting AD diagnosis. After 20 weeks, significant between-group differences in the CGIC (p= 0.001), CDR-SB (p= 0.032), and CDR Global (p= 0.037) tests and borderline significance in the ADAS-Cog test (p= 0.053). CGIC, CDR Global, and ADAS-Cog showed improvement in cognition and function and CDR-SB showed significantly less progression, compared to the control group which worsened in all four measures. Aβ42/40 ratio increased in the intervention group and decreased in the control group (p = 0.003). There was a significant correlation between lifestyle and both cognitive function and the plasma Aβ42/40 ratio. The microbiome improved only in the intervention group (p <0.0001).

Conclusions
Comprehensive lifestyle changes may significantly improve cognition and function after 20 weeks in many patients with MCI or early dementia due to AD.

Trial registration
Approved by Western Institutional Review Board on 12/31/2017 (#20172897) and by Institutional Review Boards of all sites. This study was registered retrospectively with clinicaltrials.gov on October 8, 2020 (NCT04606420, ID: 20172897).
Genetic and phenotypic heterogeneity in early neurodevelopmental traits in the Norwegian Mother, Father and Child Cohort Study
Authors: Hegemann Laura , Corfield Elizabeth C. , Askelund Adrian Dahl , Allegrini Andrea G. , Askeland Ragna Bugge , Ronald Angelica , Ask Helga , St Pourcain Beate , Andreassen Ole A. , Hannigan Laurie J. , Havdahl Alexandra 
Published: June 2024

Abstract
Background
Autism and different neurodevelopmental conditions frequently co-occur, as do their symptoms at sub-diagnostic threshold levels. Overlapping traits and shared genetic liability are potential explanations.

Methods
In the population-based Norwegian Mother, Father, and Child Cohort study (MoBa), we leverage item-level data to explore the phenotypic factor structure and genetic architecture underlying neurodevelopmental traits at age 3 years (N = 41,708–58,630) using maternal reports on 76 items assessing children’s motor and language development, social functioning, communication, attention, activity regulation, and flexibility of behaviors and interests.

Results
We identified 11 latent factors at the phenotypic level. These factors showed associations with diagnoses of autism and other neurodevelopmental conditions. Most shared genetic liabilities with autism, ADHD, and/or schizophrenia. Item-level GWAS revealed trait-specific genetic correlations with autism (items rg range = − 0.27–0.78), ADHD (items rg range = − 0.40–1), and schizophrenia (items rg range = − 0.24–0.34). We find little evidence of common genetic liability across all neurodevelopmental traits but more so for several genetic factors across more specific areas of neurodevelopment, particularly social and communication traits. Some of these factors, such as one capturing prosocial behavior, overlap with factors found in the phenotypic analyses. Other areas, such as motor development, seemed to have more heterogenous etiology, with specific traits showing a less consistent pattern of genetic correlations with each other.

Conclusions
These exploratory findings emphasize the etiological complexity of neurodevelopmental traits at this early age. In particular, diverse associations with neurodevelopmental conditions and genetic heterogeneity could inform follow-up work to identify shared and differentiating factors in the early manifestations of neurodevelopmental traits and their relation to autism and other neurodevelopmental conditions. This in turn could have implications for clinical screening tools and programs.
Relationship between sex biases in gene expression and sex biases in autism and Alzheimer’s disease
Authors: Fass Stuart B. , Mulvey Bernard , Chase Rebecca , Yang Wei , Selmanovic Din , Chaturvedi Sneha M. , Tycksen Eric , Weiss Lauren A. , Dougherty Joseph D. 
Published: June 2024

Abstract
Background
Sex differences in the brain may play an important role in sex-differential prevalence of neuropsychiatric conditions.

Methods
In order to understand the transcriptional basis of sex differences, we analyzed multiple, large-scale, human postmortem brain RNA-Seq datasets using both within-region and pan-regional frameworks.

Results
We find evidence of sex-biased transcription in many autosomal genes, some of which provide evidence for pathways and cell population differences between chromosomally male and female individuals. These analyses also highlight regional differences in the extent of sex-differential gene expression. We observe an increase in specific neuronal transcripts in male brains and an increase in immune and glial function-related transcripts in female brains. Integration with single-nucleus data suggests this corresponds to sex differences in cellular states rather than cell abundance. Integration with case–control gene expression studies suggests a female molecular predisposition towards Alzheimer’s disease, a female-biased disease. Autism, a male-biased diagnosis, does not exhibit a male predisposition pattern in our analysis.

Conclusion
Overall, these analyses highlight mechanisms by which sex differences may interact with sex-biased conditions in the brain. Furthermore, we provide region-specific analyses of sex differences in brain gene expression to enable additional studies at the interface of gene expression and diagnostic differences.

Graphical Abstract
What secondary research evidence exists on the effects of forest management after disturbances: a systematic map protocol
Authors: Baumeister Moritz , Meyer Markus A. 
Published: June 2024

Abstract
Background
Forest disturbances are projected to increase in intensity and frequency in the upcoming decades. The projected change in disturbance regimes is expected to alter the provision of ecosystem services and affect biodiversity. Both are critical for forest ecosystems to provide livelihoods for human societies. Forest management after natural disturbances shapes successional pathways of forest ecosystems. Therefore, the management of post-disturbance sites deserves critical attention to avoid negative effects of management interventions on ecosystem services and biodiversity. The two most common management interventions after natural disturbances are salvage logging (comparator: no salvage logging) and tree planting (comparator: natural regeneration). This planned systematic map of reviews aims to aggregate the existing evidence syntheses on the implications of common forest management interventions after natural disturbances on successional trajectories with regard to selected ecosystem services and biodiversity. Evidence-based post-disturbance management is highly relevant for protected area management as well as for the management of commercial forests.

Methods
We will systematically search the databases Scopus, Web of Science Core Collection and the Forest Science Collection of the CABI Digital Library for reviews and meta-analyses (after 2003). We will apply eligibility criteria for review selection and assess the evidence synthesis validity of selected reviews using the most recent version of CEESAT (Collaboration for Environmental Evidence Synthesis Assessment Tool). The results will be displayed in topic subgroups in summary of scope and summary of findings tables.
Identification of porcine fast/slow myogenic exosomes and their regulatory effects on lipid accumulation in intramuscular adipocytes
Authors: Zhao Tiantian , Tian Tingting , Yu He , Cao Chaoyue , Zhang Ziyi , He Zhaozhao , Ma Zeqiang , Cai Rui , Li Fengna , Pang Weijun 
Published: June 2024

Abstract
Background
Pork quality is affected by the type of muscle fibers, which is closely related to meat color, tenderness and juiciness. Exosomes are tiny vesicles with a diameter of approximately 30–150 nm that are secreted by cells and taken up by recipient cells to mediate communication. Exosome-mediated muscle-fat tissue crosstalk is a newly discovered mechanism that may have an important effect on intramuscular fat deposition and with that on meat quality. Various of adipose tissue-derived exosomes have been discovered and identified, but the identification and function of muscle exosomes, especially porcine fast/slow myotube exosomes, remain unclear. Here, we first isolated and identified exosomes secreted from porcine extensor digitorum longus (EDL) and soleus (SOL), which represent fast and slow muscle, respectively, and further explored their effects on lipid accumulation in longissimus dorsi adipocytes.

Results
Porcine SOL-derived exosomes (SOL-EXO) and EDL-derived exosomes (EDL-EXO) were first identified and their average particle sizes were approximately 84 nm with double-membrane disc- shapes as observed via transmission electron microscopy and scanning electron microscopy. Moreover, the intramuscular fat content of the SOL was greater than that of the EDL at 180 days of age, because SOL intramuscular adipocytes had a stronger lipid-accumulating capacity than those of the EDL. Raman spectral analysis revealed that SOL-EXO protein content was much greater than that of EDL-EXO. Proteomic sequencing identified 72 proteins that were significantly differentially expressed between SOL-EXO and EDL-EXO, 31 of which were downregulated and 41 of which were upregulated in SOL-EXO.

Conclusions
Our findings suggest that muscle-fat tissue interactions occur partly via SOL-EXO promoting adipogenic activity of intramuscular adipocytes.
The impact of the colonial architecture on the urban sustainability of Laghouat city in Algeria: ksar of Laghouat as a case
Authors: Mahcar Fatiha Imane , Durak Selen , Benabbou Rachida , Arslan Tülin Vural 
Published: June 2024

Abstract
Among the risks that cities are exposed to, colonization emerges as a multifaceted concern representing historical and modern dimensions that can significantly impact a city’s urban sustainability. This study explores the diverse implications of colonization on the urban sustainability with a focus on the Ksar of Laghouat in Laghouat city, Algeria. It examines the urban adaptation cycle and the imprint left by the colonial era on the fabric of the city. Utilizing the method of adaptive cycle approach and transfer entropy analysis, our goal is to quantify interaction on the historical and urban development of potential, connectedness, and resilience of Laghouat city. This study enhances the understanding of the Architectural heritage of Algeria and highlights dynamics between traditional and colonial architectural dimensions of Ksar of Laghouat. By assimilating the impact of colonization on the urban development of the city, we aim to improve the resilience and sustainability of Laghouat, through empowering its local community, and providing decision-makers with valuable sustainable strategies and adaptation mechanisms for future urban visions of the city.
From concerns to benefits: a comprehensive study of ChatGPT usage in education
Authors: Jo Hyeon 
Published: June 2024

AbstractArtificial Intelligence (AI) chatbots are increasingly becoming integral components of the digital learning ecosystem. As AI technologies continue to evolve, it is crucial to understand the factors influencing their adoption and use among students in higher education. This study is undertaken against this backdrop to explore the behavioral determinants associated with the use of the AI Chatbot, ChatGPT, among university students. The investigation delves into the role of ChatGPT’s self-learning capabilities and their influence on students’ knowledge acquisition and application, subsequently affecting the individual impact. It further elucidates the correlation of chatbot personalization with novelty value and benefits, underscoring their importance in shaping students’ behavioral intentions. Notably, individual impact is revealed to have a positive association with perceived benefits and behavioral intention. The study also brings to light potential barriers to AI chatbot adoption, identifying privacy concerns, technophobia, and guilt feelings as significant detractors from behavioral intention. However, despite these impediments, innovativeness emerges as a positive influencer, enhancing behavioral intention and actual behavior. This comprehensive exploration of the multifaceted influences on student behavior in the context of AI chatbot utilization provides a robust foundation for future research. It also offers invaluable insights for AI chatbot developers and educators, aiding them in crafting more effective strategies for AI integration in educational settings.
Impact of tannery wastes on anaerobic co-digestion: enhancing biogas production and process efficiency
Authors: Andriamanohiarisoamanana Fetra J. , Farghali Mohamed , Mohamed Israa M. A. , Yoshida Gen , Shiota Kazuya , Ihara Ikko 
Published: June 2024

AbstractThe study investigates the potential of anaerobic co-digestion (AcoD) as a sustainable solution for managing putrescible organic waste generated by leather processing. Three experiments were conducted to assess the impact of various tannery wastes, pretreatment methods, and waste combinations on methane production. Experiment 1 demonstrated that co-digesting tannery wastewater primary sludge (TWPS) and fleshings significantly increased methane yield compared to digesting TWPS alone, though the addition of chromium- and vegetable-tanned leather wastes decreased yield. Experiment 2 explored TWPS pretreatment methods and found that ultrasonic pretreatment increased soluble chemical oxygen demand (SCOD) but did not significantly improve methane yield, suggesting that pretreatment may not be necessary. Experiment 3 revealed that increasing the proportion of fleshings to TWPS resulted in higher methane yield, ranging from 226.52 mL/gVS with 6% fleshings to 395.71 mL/gVS and 538.34 mL/gVS with 12% and 20% of fleshings, respectively. Additionally, this increase in fleshings also led to a reduction in digester volume. These findings highlight the importance of AcoD in addressing both environmental and economic challenges in the leather industry.
Graphical Abstract
Phylogenomic approaches reveal a robust time-scale phylogeny of the Terminal Fusarium Clade
Authors: Lizcano Salas Andrés Felipe , Duitama Jorge , Restrepo Silvia , Celis Ramírez Adriana Marcela 
Published: June 2024

AbstractThe Terminal Fusarium Clade (TFC) is a group in the Nectriaceae family with agricultural and clinical relevance. In recent years, various phylogenies have been presented in the literature, showing disagreement in the topologies, but only a few studies have conducted analyses on the divergence time scale of the group. Therefore, the evolutionary history of this group is still being determined. This study aimed to understand the evolutionary history of the TFC from a phylogenomic perspective. To achieve this objective, we performed a phylogenomic analysis using the available genomes in GenBank and ran eight different pipelines. We presented a new robust topology of the TFC that differs at some nodes from previous studies. These new relationships allowed us to formulate new hypotheses about the evolutionary history of the TFC. We also inferred new divergence time estimates, which differ from those of previous studies due to topology discordances and taxon sampling. The results suggested an important diversification process in the Neogene period, likely associated with the diversification and predominance of terrestrial ecosystems by angiosperms. In conclusion, we presented a robust time-scale phylogeny that allowed us to formulate new hypotheses regarding the evolutionary history of the TFC.
How to Listen Otherwise
Authors: Ivry Henry 
Published: June 2024

Abstract
Music occupies a central role in the Black radical tradition. It is often understood as a mode of radical rebellion, sonic insurgency, and fugitive possibility. In Black music and sound we can listen to the competing rhythms and tempos of a Black world outside the strictures of white supremacist narratives. What is often glossed over in these conversations, however, is how Black music plays an explicitly ecological role. This article thinks about how Black sound is instrumental in refiguring what Brent Hayes Edwards calls the “historical transcript,” while also gesturing toward how Black sound seeks out a worlding between human and nonhuman entities through an endless capacity for reconfiguration and reorganization. Arguing that Black music is both historical archive and futural conjecture, this article examines a series of records that materialize worlds outside the locked grooves of anti-Black violence and environmental destruction.
Study on the Temperature Distribution and Natural Frequency of a Circular Saw Blade during Three Types of Wood Sawing Processes
Authors: Zhang Yansong , Li Bo 
Published: June 2024

Abstract
The stability of a circular saw blade during the cutting process affects the knife life and the material utilization rate. In this article, continuous sawing experiments were carried out on medium-density fiberboard, Pterocarpus soyauxii board, and reconstituted bamboo lumber board. The temperature distribution of the saw blade surface was measured. The natural frequency of the saw blade under thermal stress was analyzed by the finite element method. The results show that the material density is positively correlated with the edge temperature of the saw blade. Greater temperature differences within the saw blade lead to worsening dynamic stability. When cutting the reconstituted bamboo lumber board, the saw blade will suddenly lose stability, and the surface temperature will rise rapidly, which greatly shortens the life of the saw blade.
Photonic crystal fiber temperature sensor based on self-phase modulation and solitons
Authors: Gao Yuanhongliu , Chen Xiaoyu , Pan Meiting , Cheng Tonglei , Yan Xin 
Published: June 2024

In this paper, we investigated the temperature sensing properties of self-phase modulation (SPM) combined with solitons in photonic crystal fibers by experimental verification. Pumped in the normal dispersion region close to the zero-dispersion point, SPM allows the resulting spectrum to extend into the normal dispersion region, generating solitons. By detecting the wavelength shift of the soliton at 900 nm, 2.366 W, the maximum sensitivity is 0.98 nm/°C. To the best of our knowledge, this is the first study of temperature sensing using SPM in combination with solitons, which broadens the boundaries of nonlinear-based sensors and holds considerable promise for high-performance temperature detection in a variety of demanding scenarios, such as railway safety and national security.
Early neonatal mortality and determinants in sub-Saharan Africa: Findings from recent demographic and health survey data
Authors: Tamir Tadesse Tarik , Mohammed Yirgalem , Kassie Alemneh Tadesse , Zegeye Alebachew Ferede 
Published: June 2024

Introduction
Neonatal mortality during the first week of life is a global issue that is responsible for a large portion of deaths among children under the age of five. There are, however, very few reports about the issue in sub-Saharan Africa. For the sake of developing appropriate policies and initiatives that could aid in addressing the issue, it is important to study the prevalence of mortality during the early neonatal period and associated factors. Thus, the aim of this study was to ascertain the prevalence of and pinpoint the contributing factors to early neonatal mortality in sub-Saharan Africa.

Method
Data from recent demographic and health surveys in sub-Saharan African countries was used for this study. The study included 262,763 live births in total. The determinants of early newborn mortality were identified using a multilevel mixed-effects logistic regression model. To determine the strength and significance of the association between outcome and explanatory variables, the adjusted odds ratio (AOR) at a 95% confidence interval (CI) was computed. Independent variables were deemed statistically significant when the p-value was less than the significance level (0.05).

Result
Early neonatal mortality in sub-Saharan Africa was 22.94 deaths per 1,000 live births. It was found to be significantly associated with maternal age over 35 years (AOR = 1.77, 95% CI: 1.34–2.33), low birth weight (AOR = 3.27, 95% CI: 2.16, 4.94), less than four ANC visits (AOR = 1.12, 95% CI: 1.01, 1.33), delivery with caesarean section (AOR = 1.81, 95% CI: 1.30–2.5), not having any complications during pregnancy (AOR = 0.76, 95% CI: 0.61, 94), and community poverty (AOR = 1.32, 95% CI: 1.05–1.65).

Conclusion
This study found that about twenty-three neonates out of one thousand live births died within the first week of life in sub-Saharan Africa. The age of mothers, birth weight, antenatal care service utilization, mode of delivery, multiple pregnancy, complications during pregnancy, and community poverty should be considered while designing policies and strategies targeting early neonatal mortality in sub-Saharan Africa.