bluuebunny/crossref_metadata_2025_split huggingface dataset:
تأثير تمرينات مهارية لاهوائية بالأسلوبين المفرد والمركب في عدد من القدرات البدنية للاعبات كرة القدم الخماسي
Authors: Assit.Prof. Dr. Omar Majeed Agha  
Published: May 2024

من خلال خبرة الباحث الميدانية وملاحظتهم لتدريبات ومباريات نادي الفتاة الرياضي وجد ان هناك قصورا في مستوى الاعداد المهاري لمدربي كرة القدم، إذ لاحظ اهتمام المدربين العاملين بتنمية المهارات الاساسية بشكل منفرد فقط. لذا ارتأى الباحث تجريب أسلوبين تدريبيين في تطوير المهارات الاساسية بكرة القدم لنادي الفتاة من خلال اعتماد أسلوب تدريب المهارات بشكل مفرد، ، في حين اعتمد الاسلوب الثاني على تدريب أكثر من مهارة في تمرين مهاري واحد، لاجل إجراء مقارنة علمية تبين تأثير كل أسلوب مهاري على كافة الجوانب البدنية استخدم الباحث المنهج التجريبي لملائمته وطبيعة مشكلة البحث .تم تحديد مجتمع البحث بالطريقة العمدية من اللاعبات نادي الفتاة اربيل بكرة القدم الخماسي التي شاركت في بطولة اقليم كردستان للموسم 2022-2023 بالغ عددهم 14 لاعبا , ان تموج حركة الحمل التدريبي في البرنامجين التدريبيين كان معتمداً على زيادة الحجم التدريبي الكلي لكل دورة صغرى . وقد استنتج الباحث مايلي :

حقق التمرينات المهارية للاهوائية بالأسلوب المفرد تطوراً جيداً في كافة المتغيرات البدنية قيد البحث
حققت التمرينات المهارية للاهوائية بالأسلوب المركب تطوراً جيداً في كافة المتغيرات البدنية قيد البحث.
La imposibilidad de acceder al derecho a la jubilación por deudas de los patronos. Una mirada desde el procedimiento administrativo del IESS y la sentencia No. 1024-19-JP/21
Authors: Vallejo-Quiroga Fanny 
Published: May 2024

Dentro del presente artículo resaltaremos la vulneración de derechos que sufren los trabajadores cuando su empleador incumple con el pago de aportaciones al IESS pese a que se ha descontado dicho aporte al trabajador.
Este incumplimiento por parte del empleador imposibilita al trabajador a que pueda acceder al derecho de jubilación, si bien es cierto el IESS faculta la creación de planillas excepcionales para que sea el trabajador o el empleador quien cancele lo adeudado y así pueda el trabajador acceder a la jubilación, surge una gran interrogante ¿es suficiente este acto de simple administración para respaldar los derechos del trabajador?, la respuesta que conlleva esta pregunta demuestra efectivamente que el sistema de coactiva que rige al IESS no cumple con los estándares básicos de recaudación, pues es un proceso que al no ser ágil provoca una vulneración de derechos de doble afectación pues el IESS en lugar de enfocarse en el cobro de la mora patronal al patrono se enfoca en cobrar montos adeudados que en la mayoría de los casos paga el trabajador al verse sumergido en su desesperación para poder acceder a su derecho de jubilación.
Demostraremos que no existe cumplimiento a lo ordenado en la sentencia No. 1024-19-JP/21, pues en caso de mora patronal se impide la jubilación al trabajador.
Estrategias competitivas para exportación de uva ecuatoriana como fruta no tradicional hacía Corea del Sur.
Authors: Flores-Aguilar Paula , Capa-Tejedor Marcela 
Published: May 2024

Ecuador posee una gran biodiversidad y capacidad agrícola para la producción de la uva de mesa, por otra parte, está Corea del Sur con un gran interés constante en frutas no tradicionales. El Ministerio de Producción Comercio Exterior, Inversiones y Pesca aspira que las exportaciones agroalimentarias del Ecuador incluyendo la uva de mesa, tomen presencia en el mercado de Corea del Sur, sin embargo, si un país pretende introducir su producto en un mercado desconocido y no cuenta con un plan de acción sólida, se enfrenta a diversos desafíos. El objetivo de la investigación es determinar estrategias competitivas para la exportación de uva ecuatoriana mediante estudios descriptivos y comparativos que permitan ingresar la uva de mesa como un producto no tradicional al mercado de Corea del Sur. metodología empleada fue descriptiva, de diseño experimental, se realizó un estudio de documento en donde se utilizaron datos cuantitativos y cualitativos de páginas webs que muestran estadísticas del comercio para el desarrollo internacional del país como Trade Map. En los resultados encontrados se afirma que anteriormente Corea del Sur no ha estado interesado en las frutas no tradicionales por el hecho de que no existían acuerdos o tratados con Ecuador y solo disponía del programa de intercambio de conocimientos KSP. Por ende, es que el Acuerdo Estratégico de Cooperación Económica (SECA) que se ha implementado actualmente entre los dos países, opta como una herramienta de estrategia competitiva beneficiosa para que el Ecuador pueda tomar posicionamiento en el mercado asiático.
Liderazgo remoto y su impacto en el clima organizacional en una institución financiera en la ciudad de Machala, provincia de El Oro
Authors: Frías-Maura Lorena , Muñoz-Palacio Fernando 
Published: May 2024

El estudio realizado sobre el impacto del liderazgo remoto en el clima organizacional en una Institución Financiera en la ciudad de Machala, se basó en un enfoque descriptivo, observacional, no experimental, transversal y correlacional. La población comprendió a 22 empleados. Se utilizó un cuestionario distribuido en tres partes, la primera para datos generales, la segunda, con 30 ítems para la variable liderazgo remoto y la 3era parte con 40 ítems para el clima organizacional. Los resultados mostraron que que la mayoría de los empleados eran mujeres en el área operativa (91%). En cuanto al liderazgo remoto, los empleados mostraron una alta satisfacción, especialmente en las dimensiones de liderazgo (77.27%), compromiso (59.09%), competencias (59.09%), y habilidades e-sociales y de comunicación (77.27%). Sin embargo, aspectos como la motivación, las condiciones de trabajo, la solución de conflictos y el trabajo en equipo presentaron áreas de mejora en el clima organizacional, con un (4,55%). Se encontró una relación positiva y significativa entre el liderazgo remoto y el clima organizacional, con un Rho de Spearman de 0,869 (IC 95% y p <0,001), lo que sugiere que un liderazgo remoto efectivo puede contribuir a un clima organizacional más favorable en la institución financiera estudiada
An integrative multi-omic analysis defines gut microbiota, mycobiota, and metabolic fingerprints in ulcerative colitis patients
Authors: Scanu Matteo , Toto Francesca , Petito Valentina , Masi Letizia , Fidaleo Marco , Puca Pierluigi , Baldelli Valerio , Reddel Sofia , Vernocchi Pamela , Pani Giovambattista , Putignani Lorenza , Scaldaferri Franco , Del Chierico Federica 
Published: May 2024

BackgroundUlcerative colitis (UC) is a multifactorial chronic inflammatory bowel disease (IBD) that affects the large intestine with superficial mucosal inflammation. A dysbiotic gut microbial profile has been associated with UC. Our study aimed to characterize the UC gut bacterial, fungal, and metabolic fingerprints by omic approaches.MethodsThe 16S rRNA- and ITS2-based metataxonomics and gas chromatography–mass spectrometry/solid phase microextraction (GC–MS/SPME) metabolomic analysis were performed on stool samples of 53 UC patients and 37 healthy subjects (CTRL). Univariate and multivariate approaches were applied to separated and integrated omic data, to define microbiota, mycobiota, and metabolic signatures in UC. The interaction between gut bacteria and fungi was investigated by network analysis.ResultsIn the UC cohort, we reported the increase of Streptococcus, Bifidobacterium, Enterobacteriaceae, TM7-3, Granulicatella, Peptostreptococcus, Lactobacillus, Veillonella, Enterococcus, Peptoniphilus, Gemellaceae, and phenylethyl alcohol; and we also reported the decrease of Akkermansia; Ruminococcaceae; Ruminococcus; Gemmiger; Methanobrevibacter; Oscillospira; Coprococus; Christensenellaceae; Clavispora; Vishniacozyma; Quambalaria; hexadecane; cyclopentadecane; 5-hepten-2-ol, 6 methyl; 3-carene; caryophyllene; p-Cresol; 2-butenal; indole, 3-methyl-; 6-methyl-3,5-heptadiene-2-one; 5-octadecene; and 5-hepten-2-one, 6 methyl. The integration of the multi-omic data confirmed the presence of a distinctive bacterial, fungal, and metabolic fingerprint in UC gut microbiota. Moreover, the network analysis highlighted bacterial and fungal synergistic and/or divergent interkingdom interactions.ConclusionIn this study, we identified intestinal bacterial, fungal, and metabolic UC-associated biomarkers. Furthermore, evidence on the relationships between bacterial and fungal ecosystems provides a comprehensive perspective on intestinal dysbiosis and ecological interactions between microorganisms in the framework of UC.
Clinical application value of metagenome next-generation sequencing in pulmonary diffuse exudative lesions: a retrospective study
Authors: Wu Yisong , Wu Jian , Xu Nengluan , Lin Ming , Yue Wenxiang , Chen Yusheng , Zhang Qiongyao , Li Hongru 
Published: May 2024

ObjectiveThis study aims to investigate the clinical application value of Metagenome Next-Generation Sequencing (mNGS) for pulmonary diffuse exudative lesions.MethodsFrom January 1, 2014, to November 31, 2021, 136 cases with chest radiologic presentations of pulmonary diffuse exudative lesions admitted to Fujian Provincial Hospital were included in the study; of those, 77 patients underwent mNGS pathogen detection. Based on the pathogen detection outcomes and clinical diagnoses, patients were categorized into an infection group (IG) and a non-infection group (NIG). A comparison was made between the diagnostic efficacy of the mNGS technique and traditional culture methods. Meanwhile, 59 patients clinically identified as having infectious pulmonary diffuse exudative lesions but who did not receive mNGS testing were designated as the non-NGS infection group (non-IG). A retrospective cohort study was conducted on patients in both the IG and non-IG, with a 30-day all-cause mortality endpoint used for follow-up.OutcomesWhen compared to conventional culture methods, mNGS demonstrated an approximate 35% increase in sensitivity (80.0% vs 45.5%, P&lt;0.001), without significant disparity in specificity (77.3% vs 95.5%, P=0.185). Under antibiotic exposure, the positivity rate detected by mNGS was notably higher than that by traditional culture methods, indicating that mNGS is less affected by exposure to antibiotics (P&lt;0.05). Within 30 days, the all-cause mortality rate for patients in the IG versus the non-IG was 14.55% and 37.29%, respectively (P&lt;0.05). Following a COX regression analysis to adjust for confounding factors, the analysis revealed that a CURB-65 score ≥3 points (HR=3.348, P=0.001) and existing cardiovascular disease (HR=2.473, P=0.026) were independent risk factors for these patients. Conversely, mNGS testing (HR=0.368, P=0.017) proved to be an independent protective factor.ConclusionmNGS technology makes it easier to pinpoint the cause of pulmonary diffuse infectious exudative lesions without much interference from antibiotics, helping doctors spot and diagnose these issues early on, thereby playing a key role in helping them decide the best treatment approach for patients. Such conclusions may have a bias, as the performance of traditional methods might be underestimated due to the absence of complete results from other conventional diagnostic techniques like serological testing and PCR.
Martensitic Transition, Magnetic, Microstructural and Exchange Bias Properties of Melt Spun Ribbons of Mn-Ni-Sn Shape Memory Heusler Alloy
Authors: Sharma Jyoti , Suresh K. G. , Raja M. Manivel , Walke Pravin 
Published: May 2024

In the present report, we have studied the structural, microstructural, magnetic, exchange bias (EB) properties and magnetoresistance (MR) in Mn rich (Mn at. ∼50%) Mn50Ni50−xSnx (x = 10) shape memory Heusler alloy ribbons, prepared using the melt spinning method. These ribbons were found to exhibit a first order structural (i.e., martensitic) transition at around 205 K from the high temperature austenite to the low temperature martensite phase. The martensitic transition occurs at comparatively lower temperatures in these ribbons than in the same bulk alloy. Curie temperature of the austenite phase (TCA) is found to be larger i.e., around room temperature than that of bulk alloy. A significant EB field (HEB) of around 960 Oe has been observed at 2 K for these ribbons, which is found to be comparable to that reported for other Heusler systems. The presence of the EB effect in these ribbons is attributed to the coexistence of FM/AFM exchange interactions in the martensite phase. They are also found to show a maximum negative MR of around 12% near the martensitic transition, for 50 kOe field change. Investigation of DC magnetization, AC susceptibility measurements and the observation of training effect (i.e., characteristic feature of EB) strongly corroborates with the coexistence of FM/AFM exchange interactions in the martensite phase of these ribbons, which results in the large EB. The effects of temperature and magnetic field on the EB properties and MR have also been studied here.
A retrospective study of 68Ga-FAPI PET/CT in differentiating the nature of pulmonary lesions
Authors: Xie Yang , Tang Wenxin , Ma Jiao , Chen Yue 
Published: May 2024

PurposeThis study aimed to investigate the characteristics of various pulmonary lesions as revealed by 68Ga-FAPI PET/CT and to determine the utility of 68Ga-FAPI PET/CT in distinguishing the nature of these pulmonary lesions.MethodsA retrospective analysis was conducted on 99 patients with pulmonary lesions, who were categorized into three distinct groups: primary lung tumors (G1), metastatic lung tumors (G2), and benign lesions (G3). Each participant underwent a 68Ga-FAPI PET/CT scan. Among these groups, variables such as the Tumor/Background Ratio (TBR), Maximum Standardized Uptake Value (SUVmax), and the true positive rate of the lesions were compared. Furthermore, the FAPI uptake in nodular-like pulmonary lesions (d&lt;3cm) and those with irregular borders was evaluated across the groups. A correlation analysis sought to understand the relationship between FAPI uptake in primary and pulmonary metastatic lesions.ResultsThe study’s participants were composed of 52 males and 47 females, with an average age of 56.8 ± 13.2 years. A higher uptake and detection rate for pulmonary lesions were exhibited by Group G1 compared to the other groups (SUVmax [G1 vs. G2 vs. G3: 9.1 ± 4.1 vs. 6.1 ± 4.1 vs. 5.3 ± 5.8], P&lt;0.05; TBR [G1 vs. G2 vs. G3: 6.2 ± 2.4 vs. 4.1 ± 2.2 vs. 3.2 ± 2.7], P&lt;0.01; true positive rate 95.1% vs. 88% vs. 75.6%]. In nodular-like lung lesions smaller than 3 cm, G1 showed a significantly higher FAPI uptake compared to G2 and G3 (SUVmax [G1 vs. G2 vs. G3: 8.8 ± 4.3 vs. 5.2 ± 3.2 vs. 4.9 ± 6.1], P&lt;0.01; TBR [G1 vs. G2 vs. G3: 5.7 ± 2.7 vs. 3.7 ± 2.1 vs. 3.3 ± 4.4], P&lt;0.05). Both G1 and G2 demonstrated significantly elevated FAPI agent activity in irregular-bordered pulmonary lesions when compared to G3 (SUVmax [G1 vs. G2 vs. G3: 10.9 ± 3.3 vs. 8.5 ± 2.7 vs. 4.6 ± 2.7], P&lt;0.01; TBR [G1 vs. G2 vs. G3: 7.2 ± 2.1 vs. 6.4 ± 1.3 vs. 3.2 ± 2.4], P&lt;0.01). A positive correlation was identified between the level of 68Ga-FAPI uptake in primary lesions and the uptake in pulmonary metastatic lesions within G2 (r=0.856, P&lt;0.05).Conclusion68Ga-FAPI PET/CT imaging proves to be of significant value in the evaluation of pulmonary lesions, offering distinctive insights into their nature.
Predicting the geographical distribution and niche characteristics of Cotoneaster multiflorus based on future climate change
Authors: Huang Qiuliang , Liu Haoyang , Li Changshun , Zhu Xiaoru , Yuan Zongsheng , Lai Jialiang , Cao Minghui , Huang Zhenbei , Yang Yushan , Zhuo Shenglan , Lü Zengwei , Zhang Guofang 
Published: May 2024

IntroductionArid and semi-arid regions are climate-sensitive areas, which account for about 40% of the world’s land surface area. Future environment change will impact the environment of these area, resulting in a sharp expansion of arid and semi-arid regions. Cotoneaster multiflorus is a multi-functional tree species with extreme cold, drought and barren resistance, as well as ornamental and medicinal functions. It was found to be one of the most important tree species for ecological restoration in arid and semi-arid areas. However, bioclimatic factors play an important role in the growth, development and distribution of plants. Therefore, exploring the response pattern and ecological adaptability of C. multiflorus to future climate change is important for the long-term ecological restoration of C. multiflorus in arid and semi-arid areas.MethodsIn this study, we predicted the potential distribution of C. multiflorus in China under different climate scenarios based on the MaxEnt 2.0 model, and discussed its adaptability and the major factors affecting its geographical distribution.ResultsThe major factors that explained the geographical distribution of C. multiflorus were Annual precipitation (Bio12), Min air temperature of the coldest month (Bio6), and Mean air temperature of the coldest quarter (Bio11). However, C. multiflorus could thrive in environments where Annual precipitation (Bio12) &gt;150 mm, Min air temperature of the coldest month (Bio6) &gt; -42.5°C, and Mean air temperature of the coldest quarter (Bio11) &gt; -20°C, showcasing its characteristics of cold and drought tolerance. Under different future climate scenarios, the total suitable area for C. multiflorus ranged from 411.199×104 km² to 470.191×104 km², which was 0.8~6.14 percentage points higher than the current total suitable area. Additionally, it would further shift towards higher latitude.DiscussionThe MaxEnt 2.0 model predicted the potential distribution pattern of C. multiflorus in the context of future climate change, and identified its ecological adaptability and the main climatic factors affecting its distribution. This study provides an important theoretical basis for natural vegetation restoration in arid and semi-arid areas.
Mycobactin analogue interacting with siderophore efflux-pump protein: insights from molecular dynamics simulations and whole-cell assays
Authors: Shyam Mousumi , Thakur Abhishek , Velez Caroline , Daniel Chris , Acevedo Orlando , Bhakta Sanjib , Jayaprakash Venkatesan 
Published: May 2024

IntroductionIn response to continued public health emergency of antimicrobial resistance (AMR), a significant key strategy is the discovery of novel mycobacterial efflux-pump inhibitors (EPIs) as potential adjuvants in combination drug therapy. Interest in identifying new chemotypes which could potentially synergize with the existing antibiotics and can be deployed as part of a combination therapy. This strategy could delay the emergence of resistance to existing antibiotics and increase their efficacy against resistant strains of mycobacterial species. In recent decades, notable approaches have been accounted for EPI development and have resulted in the discovery of several EPIs including SQ109 and AU1235. In context, to accelerate newer EPIs with novel mode of action here we have discussed mycobactin analogues and highlighted in silico binding orientation with siderophore efflux-pump proteins MmpL4/5.Methods3-(2-hydroxyphenyl)-5-(aryl)-pyrazoline series was investigated for whole-cell efflux-pump inhibitory activity against Mycobacterium smegmatis and Mycobacterium abscessus. Machine learning and molecular dynamics were performed to construct a MmpL4/5 complex embedded in a lipid bilayer to identify the putative binding site and to predict ligand-protein binding energetics. Furthermore, the identified HIT compound was investigated in synergistic assay with bedaquiline.ResultsCompound Il, 2-(5-(4-fluorophenyl)-4,5-dihydro-1H-pyrazol-3-yl)phenol, was identified as the most potent efflux pump inhibitor against M. smegmatis in whole-cell efflux-pump investigation. Followed HIT Il employed against M. abscessus for efflux-pump inhibition investigations and notable whole-cell efflux-pump inhibitory profile has been observed. The theoretical investigations predicted compound Il to be selective towards MmpL4, with significant hydrogen bonding and π-π stacking interactions effectively blocking a critical Asp-Tyr dyad interaction network necessary for proton translocation. Compound Il with bedaquiline highlighted an additive profile against the M. abscessus pathogen.ConclusionsMD simulations and whole-cell assays are indicating potential development of compound Il as an adjunct to the existing therapeutic regimen against mycobacterial infections.
Potential Environmental Reservoirs of Candida auris: A Systematic Review
Authors: Silva Isabel , Miranda Isabel M. , Costa-de-Oliveira Sofia 
Published: May 2024

Candida auris, a multidrug-resistant yeast, poses significant challenges in healthcare settings worldwide. Understanding its environmental reservoirs is crucial for effective control strategies. This systematic review aimed to review the literature regarding the natural and environmental reservoirs of C. auris. Following the PRISMA guidelines, published studies until October 2023 were searched in three databases: PubMed, Web of Science, and Scopus. Information regarding the origin, sampling procedure, methods for laboratory identification, and antifungal susceptibility was collected and analyzed. Thirty-three studies published between 2016 and 2023 in 15 countries were included and analyzed. C. auris was detected in various environments, including wastewater treatment plants, hospital patient care surfaces, and natural environments such as salt marshes, sand, seawater, estuaries, apples, and dogs. Detection methods varied, with molecular techniques often used alongside culture. Susceptibility profiles revealed resistance patterns. Phylogenetic studies highlight the potential of environmental strains to influence clinical infections. Despite methodological heterogeneity, this review provides valuable information for future research and highlights the need for standardized sampling and detection protocols to mitigate C. auris transmission.