bluuebunny/crossref_metadata_2025_split huggingface dataset:
On‐line parameter estimation for a class of time‐varying continuous systems with bounded disturbances
Authors: Chen Jie , Zhang Guozhu , Li Zhiping 
Published: June 2010

AbstractIn this paper, we proposed an on‐line parameter estimation algorithm for a class of time‐varying continuous systems with bounded disturbance. In this method, a novel polynomial approximator with a bounded regressor vector is constructed and utilized to approximate the time‐varying parameters. The direct least‐squares algorithm is employed to acquire the on‐line estimates, so that several useful properties of the direct estimation, such as fast convergence and robustness to the bounded disturbance, are reflected in our method. We have proved that the estimation error of this method is bounded. Furthermore, the bound on the Euclidean norm of the estimation error is derived. The simulation results demonstrate that this method can provide accurate estimates of time‐varying parameters even under the influence of bounded disturbance. Copyright © 2010 John Wiley & Sons, Ltd.
The Bipolar Association Case–Control Study (BACCS) and meta‐analysis: No association with the 5,10‐Methylenetetrahydrofolate reductase gene and bipolar disorder
Authors: Cohen‐Woods Sarah , Craig Ian , Gaysina Darya , Gray Joanna , Gunasinghe Cerisse , Craddock Nick , Elkin Amanda , Jones Lisa , Kennedy James , King Nicole , Korszun Ania , Knight Jo , Owen Michael , Parikh Sagar , Strauss John , Sterne Abram , Tozzi Federica , Perry Julia , Muglia Pierandrea , Vincent John , McGuffin Peter , Farmer Anne 
Published: June 2010

AbstractBipolar disorder (BD) is a complex genetic disease for which the underlying pathophysiology has yet to be fully explained. 5,10‐Methylenetetrahydrofolate reductase (MTHFR) is a crucial enzyme in folate‐mediated one‐carbon metabolism and folate deficiency can be associated with psychiatric symptoms. A single base variant in MTHFR gene (C677T) results in the production of a mildly dysfunctional thermolabile enzyme and has recently been implicated in BD. We conducted an association study of this polymorphism in 897 patients with bipolar I or bipolar II disorder, and 1,687 healthy control subjects. We found no evidence for genotypic or allelic association in this sample. We also performed a meta‐analysis of our own, and all published data, and report no evidence for association. Our findings suggest that the MTHFR C677T polymorphism is not involved in the genetic etiology of clinically significant BD. © 2010 Wiley‐Liss, Inc.
Identification of a novel genetic locus on chromosome 8p21.1–q11.23 for idiopathic basal ganglia calcification
Authors: Dai Xiaohua , Gao Yong , Xu Zhenping , Cui Xiaoniu , Liu Juan , Li Yulei , Xu Haibo , Liu Mugen , Wang Qing K. , Liu Jing Yu 
Published: June 2010

AbstractIdiopathic basal ganglia calcification (IBGC) is a neurodegenerative disorder that is characterized by basal ganglia and extrabasal ganglia calcification, and usually inherited in an autosomal dominant pattern. To date, two genetic loci for IBGC were identified on chromosomes 14q and 2q, but further genetic heterogeneity clearly exists. In this study, a large Chinese family with autosomal dominant IBGC was characterized. Linkage analysis excluded the 14q13 and 2q37 loci. The large family was then characterized by genome‐wide linkage analysis to identify a novel genetic locus for IBGC. Significant linkage was identified with markers on chromosome 8p21.1–q11.23 with a maximum LOD score of 4.10. Fine mapping defined the new genetic locus within a 25 Mb region between markers D8S1809 and D8S1833. Future studies of the candidate genes at the 8p21.1–q11.23 locus may lead to identification of a disease‐causing gene with IBGC. © 2010 Wiley‐Liss, Inc.
Positive symptoms of psychosis correlate with expression of ubiquitin proteasome genes in peripheral blood
Authors: Bousman Chad A. , Chana Gursharan , Glatt Stephen J. , Chandler Sharon D. , May Todd , Lohr James , Kremen William S. , Tsuang Ming T. , Everall Ian P. 
Published: June 2010

AbstractSeveral brain‐ and blood‐based gene expression studies in patients with psychotic disorders (e.g., schizophrenia) have identified genes in the ubiquitin proteasome system (UPS) pathway as putative biomarkers. However, to date an examination of the UPS pathway in the broader context of symptom severity in psychosis has not been conducted. The purpose of this study was to investigate the correlation between clinical scores on the Scales for the Assessment of Positive and Negative Symptoms (SAPS–SANS) and expression of 43 highly annotated genes within the UPS pathway in blood from patients with psychosis. A sample of 19 psychotic patients diagnosed with schizophrenia (n = 13) or bipolar disorder (n = 6) were recruited. Pearson's partial correlations, adjusting for gender, ethnicity, age, education, medication, smoking, and past 6‐month substance use, were performed between each of the selected UPS genes and both scales. Significant Bonferroni‐adjusted positive associations were observed between SAPS scores and two ubiquitin conjugation genes (i.e., UBE2K, SIAH2), while a negative association was observed with one deubiquitination gene (i.e., USP2). No gene expression levels were significantly associated with scores on the SANS after correction for multiple testing. Our findings suggest that dysregulation of the UPS, specifically ubiquitin conjugation and deubiquitination, may point to a possible underlying biological mechanism for severity of positive but not negative symptoms. © 2010 Wiley‐Liss, Inc.
Association of a KCNA5 gene polymorphism with systemic sclerosis–associated pulmonary arterial hypertension in the European Caucasian population
Authors: Wipff J. , Dieudé P. , Guedj M. , Ruiz B. , Riemekasten G. , Cracowski J. L. , Matucci‐Cerinic M. , Melchers I. , Humbert M. , Hachulla E. , Airo P. , Diot E. , Hunzelmann N. , Caramaschi P. , Sibilia J. , Valentini G. , Tiev K. , Girerd B. , Mouthon L. , Riccieri V. , Carpentier P. H. , Distler J. , Amoura Z. , Tarner I. , Degano B. , Avouac J. , Meyer O. , Kahan A. , Boileau C. , Allanore Y. 
Published: June 2010

AbstractObjectivePulmonary arterial hypertension (PAH) has emerged as a leading cause of death in systemic sclerosis (SSc). The genetic basis of PAH has been unraveled in recent years, with a major role played by transforming growth factor β receptors; however, some other candidate genes have also been advocated, including potassium voltage‐gated channel, shaker‐related subfamily, member 5 (KCNA5). We undertook this study to determine whether KCNA5 polymorphisms confer susceptibility to SSc and its vascular phenotype, including PAH.MethodsFour KCNA5 single‐nucleotide polymorphisms (SNPs), rs10744676, rs1860420, rs3741930, and rs2284136, were genotyped in a discovery set of 638 SSc patients and 469 controls. In addition, rs10744676 was genotyped in an independent replication sample (938 SSc patients and 564 controls) and in a cohort of 168 patients with different PAH subtypes.ResultsThe KCNA5 rs10744676 variant was found to be associated with SSc in the discovery sample, with an odds ratio (OR) of 0.62 (95% confidence interval [95% CI] 0.48–0.79, adjusted P = 0.0003) in comparison with controls (C allele frequency 11.4% versus 17.2%). When subphenotypes were investigated, an association was found solely for PAH associated with SSc (OR 0.31 [95% CI 0.13–0.71], adjusted P = 0.04). The other KCNA5 SNPs tested were not associated with any SSc subset. The above association with PAH associated with SSc was replicated in the second set. In the combined population, rs10744676 was strongly associated with PAH associated with SSc in comparison with controls (OR 0.36 [95% CI 0.21–0.63], P = 0.0002). In the independent cohort of patients with PAH, after investigating PAH subtypes, only rs10744676 showed an association with PAH associated with SSc.ConclusionOur results provide the first evidence for an association between the KCNA5 rs10744676 variant and PAH associated with SSc.
The Fms‐like tyrosine kinase 3 ligand, a mediator of B cell survival, is also a marker of lymphoma in primary Sjögren's syndrome
Authors: Tobón Gabriel J. , Renaudineau Yves , Hillion Sophie , Cornec Divi , Devauchelle‐Pensec Valérie , Youinou Pierre , Pers Jacques‐Olivier 
Published: June 2010

AbstractObjectiveTo determine if the Fms‐like tyrosine kinase 3 ligand (Flt‐3L), a cytokine implicated in B cell ontogenesis and proliferation in hematologic malignancies, might be responsible for the increased numbers of circulating Bm2 and Bm2′ B cell subsets in patients with primary Sjögren's syndrome (SS).MethodsSerum levels of Flt‐3L were measured in 64 patients with primary SS and in 20 healthy controls matched for age and sex. Flt‐3L and its receptor Flt‐3 were quantified in circulating B cells and in salivary gland (SG) biopsy tissues by immunofluorescence analysis. The effect of Flt‐3L on circulating B lymphocytes was then determined by coculture with cells of a human SG (HSG) epithelial cell line.ResultsSerum levels of Flt‐3L were increased in patients with primary SS as compared with controls (mean ± SD 135.8 ± 5.5 versus 64.4 ± 4.5 pg/ml; P < 0.001). Serum levels of Flt‐3L in primary SS patients correlated with the numbers of Bm2 and Bm2′ cells (r = 0.46, P < 0.0006), and Flt‐3 was selectively expressed in Bm2 and Bm2′ cells. B cell culture experiments showed that Flt‐3L potentiated the proliferative effect of anti‐IgM stimulation. In SGs, we found that infiltrating B cells expressed Flt‐3 and epithelial cells produced Flt‐3L. Finally, Flt‐3L levels were associated with high disease activity scores and increased risk of developing lymphoma.ConclusionSerum levels of Flt‐3L are elevated in patients with primary SS and correlate with abnormal B cell distribution. Flt‐3 is mainly expressed by Bm2 and Bm2′ cells. Serum levels of Flt‐3L might explain the clinical evolution of primary SS to B cell lymphoma that is observed in some patients, thus opening the possibility of new avenues for therapy.
Effect of absorption site on the pharmacokinetics of sublingual asenapine in healthy male subjects
Authors: Gerrits Mireille , de Greef Rik , Peeters Pierre 
Published: June 2010

AbstractAsenapine is a psychopharmacologic agent approved in the United States for the acute treatment of schizophrenia in adults and the acute treatment of manic or mixed episodes associated with bipolar I disorder with or without psychotic features in adults. It is pending approval for the treatment of schizophrenia and manic episodes associated with bipolar I disorder in Europe. Asenapine is administered as a sublingual formulation. To determine whether the pharmacokinetics of asenapine are impacted by placing the tablet buccally (‘cheeking’) or allowing the tablet to dissolve on the top of the tongue, pharmacokinetics were compared following buccal and supralingual administration versus sublingual administration. In this open‐label, randomized, 3‐way crossover trial, healthy men (n=36) received single 5 mg doses of asenapine via sublingual, supralingual and buccal routes, at least 1 week apart. With buccal administration, the area under the concentration‐over‐time curve (AUC0–∞) and peak concentration (Cmax) were, respectively, 24%, and 19% higher than with sublingual administration; these routes were not bioequivalent. With supralingual administration, AUC0–∞ and Cmax were 6% and 13% lower than with sublingual administration; bioequivalence was established based on AUC0–∞ only; bioequivalence based on Cmax could not be assessed due to 40% within‐subject variability. The most common adverse events were oral paresthesia (sublingual, 75.8%; supralingual, 55.9%; buccal, 45.7%) and somnolence (81.8%; 76.5%; 68.6%). Compared with the recommended sublingual route of asenapine administration, exposure was 24% higher with buccal administration and comparable to supralingual administration. However, differences in exposure associated with variable placement in the oral cavity did not compromise safety in healthy subjects. Copyright © 2010 John Wiley & Sons, Ltd.
Effect of varying feedstock–pretreatment chemistry combinations on the formation and accumulation of potentially inhibitory degradation products in biomass hydrolysates
Authors: Du Bowen , Sharma Lekh N. , Becker Christopher , Chen Shou‐Feng , Mowery Richard A. , van Walsum G. Peter , Chambliss C. Kevin 
Published: June 2010

AbstractA variety of potentially inhibitory degradation products are produced during pretreatment of lignocellulosic biomass. Qualitative and quantitative interrogation of pretreatment hydrolysates is paramount to identifying potential correlations between pretreatment chemistries and microbial inhibition in downstream bioconversion processes. In the present study, corn stover, poplar, and pine feedstocks were pretreated under eight different chemical conditions, which are representative of leading pretreatment processes. Pretreatment processes included: 0.7% H2SO4, 0.07% H2SO4, liquid hot water, neutral buffer solution, aqueous ammonia, lime, lime with oxygen pressurization, and wet oxidation. Forty lignocellulosic degradation products resulting from pretreatment were analyzed using high performance liquid chromatography in combination with UV spectroscopy or tandem mass spectrometry detection (HPLC‐PDA‐MS/MS) and ion chromatography (IC). Of these compounds, several have been reported to be inhibitory, including furfural, hydroxymethyl furfural, ferulic acid, 3,4‐dihydroxybenzaldehyde, syringic acid among others. Formation and accumulation of monitored compounds in hydrolysates is demonstrated to be a function of both the feedstock and pretreatment conditions utilized. Biotechnol. Bioeng. 2010;107: 430–440. © 2010 Wiley Periodicals, Inc.
The effect of carbon source on microbial community structure and Cr(VI) reduction rate
Authors: Tekerlekopoulou Athanasia G. , Tsiamis George , Dermou Eftychia , Siozios Stefanos , Bourtzis Kostas , Vayenas Dimitris V. 
Published: June 2010

AbstractIn the present work, the effect of the carbon source on microbial community structure in batch cultures derived from industrial sludge and hexavalent chromium reduction was studied. Experiments in aerobic batch reactors were carried out by amending industrial sludge with two different carbon sources: sodium acetate and sucrose. In each of the experiments performed, four different initial Cr(VI) concentrations of: 6, 13, 30 and 115 mg/L were tested. The change of carbon source in the batch reactor from sodium acetate to sucrose led to a 1.3–2.1 fold increase in chromium reduction rate and to a 5‐ to 9.5‐fold increase in biomass. Analysis of the microbial structure in the batch reactor showed that the dominant communities were bacterial species (Acinetobacter lwoffii,Defluvibacter lusatiensis,Pseudoxanthomonas japonensis,Mesorhizium chacoense, andFlavobacterium suncheonense) when sodium acetate was used as carbon source and fungal strains (Trichoderma virideandPichia jadinii), when sodium acetate was replaced by sucrose. These results indicate that the carbon source is a key parameter for microbial dynamics and enhanced chromium reduction and should be taken into account for efficient bioreactor design. Biotechnol. Bioeng. 2010;107: 478–487. © 2010 Wiley Periodicals, Inc.
Application of solid–liquid TPPBs to the production of L‐phenylacetylcarbinol from benzaldehyde using Candida utilis
Authors: Khan Tanya R. , Daugulis Andrew J. 
Published: June 2010

AbstractThe biotransformation of benzaldehyde and glucose to L‐phenylacetylcarbinol (PAC) using Candida utilis was demonstrated in a solid–liquid two‐phase partitioning bioreactor (TPPB) with the aim of reducing substrate, product, and by‐product toxicity via sequestration. Previous work in the field had used octanol as the sequestering phase of liquid–liquid TPPBs but was limited by the toxic effects of octanol on C. utilis. To improve solvent selection in any future studies, the critical log P of C. utilis was determined in the current study to be 4.8 and can be used to predict biocompatible solvents. Bioavailability tests showed alkanes and alkenes to be non‐bioavailable. As polymers are biocompatible and non‐bioavailable, a wide range of commercially available polymers was screened and it was demonstrated that polymer softness plays a key role in absorptive capability. The polymer Hytrel G3548L was selected as the second phase to sequester benzaldehyde, PAC, and benzyl alcohol, with partition coefficients of 35, 7.5, and 10, respectively. With a 9% by volume partitioning phase, 13.6 g/L biomass of C. utilis achieved an overall PAC concentration of 11 g/L, a 1.9‐fold improvement over the single‐phase case. Benzyl alcohol concentration was 4.5 g/L, a 1.6‐fold reduction. The volumetric productivity was 0.85 g/L h, a 1.2‐fold improvement over the single‐phase system. These results demonstrate a promising starting point for solid–liquid TPPBs for PAC production. Biotechnol. Bioeng. 2010;107:633–641. © 2010 Wiley Periodicals, Inc.
Reproducible fashion of the HSP70B' promoter‐induced cytotoxic response on a live cell‐based biosensor by cell cycle synchronization
Authors: Migita Satoshi , Wada Ken‐Ichi , Taniguchi Akiyoshi 
Published: June 2010

AbstractLive cell‐based sensors potentially provide functional information about the cytotoxic effect of reagents on various signaling cascades. Cells transfected with a reporter vector derived from a cytotoxic response promoter can be used as intelligent cytotoxicity sensors (i.e., sensor cells). We have combined sensor cells and a microfluidic cell culture system that can achieve several laminar flows, resulting in a reliable high‐throughput cytotoxicity detection system. These sensor cells can also be applied to single cell arrays. However, it is difficult to detect a cellular response in a single cell array, due to the heterogeneous response of sensor cells. The objective of this study was cell homogenization with cell cycle synchronization to enhance the response of cell‐based biosensors. Our previously established stable sensor cells were brought into cell cycle synchronization under serum‐starved conditions and we then investigated the cadmium chloride‐induced cytotoxic response at the single cell level. The GFP positive rate of synchronized cells was approximately twice as high as that of the control cells, suggesting that cell homogenization is an important step when using cell‐based biosensors with microdevices, such as a single cell array. Biotechnol. Bioeng. 2010;107: 561–565. © 2010 Wiley Periodicals, Inc.
ChemInform Abstract: Crystallographic Study of Novel Oxyfluoride Phases Derived from SrTiO3.
Authors: Kermoun H. , Benziada‐Taibi L. 
Published: June 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: The Superstructure KCuCe2Se6 Due to Ordering of Copper Cations.
Authors: Klawitter Y. , Naether C. , Jess I. , Bensch W. , Kanatzidis M. G. 
Published: June 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Further Contraction of ZrW2O8.
Authors: Duan N. , Kameswari U. , Sleight A. W. 
Published: June 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: fac‐Triaquatrichloroindium(III).
Authors: Aris Damian R. , Errington William , Willey Gerald R. 
Published: June 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: The Structure of Synthetic Tinsleyite K[Al2(PO4)2(OH)(H2O)] ×H2O.
Authors: Dick Stefan 
Published: June 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: NMR Spectra of AgF‐4 Ion.
Authors: Eujen Reint , Zemva Boris 
Published: June 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Developing the Chemistry of Novel Scandium β‐Diketonates for the MOCVD of Scandium‐Containing Oxides.
Authors: Fleeting Kirsty A. , Davies Hywel O. , Jones Anthony C. , O'Brien Paul , Leedham Timothy J. , Crosbie Michael J. , Wright Peter J. , Williams Dennis J. 
Published: June 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Predictions of log P for Aromatic Compounds.
Authors: Braendstroem Arne 
Published: June 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: A Catalytic System Consisting of Vanadium, Chlorosilane, and Aluminum Metal in the Stereoselective Pinacol Coupling Reaction of Benzaldehyde Derivatives.
Authors: Hirao Toshikazu , Hatano Bunpei , Imamoto Yuka , Ogawa Akiya 
Published: June 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Ferrocenyl Ligands with Two Phosphanyl Substituents in the α,ε Positions for the Transition Metal Catalyzed Asymmetric Hydrogenation of Functionalized Double Bonds.
Authors: Ireland Tania , Grossheimann Gabriele , Wieser‐Jeunesse Catherine , Knochel Paul 
Published: June 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Manganese Tetraazaporphines as Effective Catalysts for the Nuclear Oxidation of Aromatics by Peracetic Acid.
Authors: Barkanova Svetlana V. , Makarova Elena A. , Kaliya Oleg L. , Luk'yanets Eugene A. 
Published: June 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.