bluuebunny/crossref_metadata_2025_split huggingface dataset:
Qualitative assessment of patient experiences following sacrectomy
Authors: Davidge K.M. , Eskicioglu C. , Lipa J. , Ferguson P. , Swallow C.J. , Wright F.C. 
Published: April 2010

AbstractBackground and ObjectivesThe primary objective was to investigate patient experiences following sacral resection as a component of curative surgery for advanced rectal cancers, soft tissue and bone sarcomas.MethodsQualitative methods were used to examine the experiences, decision‐making, quality of life, and supportive care needs of patients undergoing sacrectomy. Patients were identified from two prospective databases between 1999 and 2007. A semi‐structured interview guide was generated and piloted. Patient interviews were transcribed verbatim and analyzed using standard qualitative research methodology. Grounded theory guided the generation of the interview guide and analysis.ResultsTwelve patients were interviewed (6 female, 32–82 years of age). The mean interview time was 34 min. Five themes were identified, including: (1) the life‐changing impact of surgery on both patients' and their family's lives, (2) patient satisfaction with immediate care in hospital, (3) significant chronic pain related to sacrectomy, (4) patients' need for additional information regarding long‐term recovery, and (5) patients' gratitude to be alive.ConclusionsSacrectomy is a life‐changing event for patients and their families. Patients undergoing sacrectomy need further information regarding the long‐term consequences of this procedure. This need should be addressed in both preoperative multi‐disciplinary consultations and at follow‐up visits. J. Surg. Oncol. 2010; 101:447–450. © 2010 Wiley‐Liss, Inc.
Cancer cell‐derived IL‐1α promotes HGF secretion by stromal cells and enhances metastatic potential in pancreatic cancer cells
Authors: Xu Donghui , Matsuo Yoichi , Ma Jiachi , Koide Shuji , Ochi Nobuo , Yasuda Akira , Funahashi Hitoshi , Okada Yuji , Takeyama Hiromitsu 
Published: April 2010

AbstractBackground and ObjectivesInterleukin (IL)‐1α and hepatocyte growth factor (HGF) play an important role in pancreatic cancer proliferation, angiogenesis, and invasiveness. The aim of this study was to investigate the cooperative role of HGF and IL‐1α in metastatic processes promoted by interactions between pancreatic cancer cells and stromal cells.MethodsExpression of IL‐1α and HGF mRNA and protein was determined by RT‐PCR and ELISA. The effect of HGF on metastatic potential was evaluated by proliferation, invasion, and angiogenesis assays using an in vitro system consisting of co‐cultured tumor cells and stromal cells.ResultsIL‐1α expression was closely correlated with metastatic potential, and cancer cell‐derived IL‐1α significantly promoted HGF expression by fibroblasts (P < 0.01). HGF not only enhanced the invasiveness and proliferation of pancreatic cancer cells, but also enhanced migration and proliferation of human umbilical vein endothelial cells (HUVECs). HGF significantly enhanced HUVEC tube formation (P < 0.01). Furthermore, the high liver‐metastatic pancreatic cancer cell line (BxPC‐3), which secretes IL‐1α, significantly enhanced HUVEC tube formation compared with the low liver‐metastatic cell line (Capan‐2), which does not produce IL‐1α (P < 0.01).ConclusionAutocrine IL‐1α and paracrine HGF co‐enhance the metastatic potential of pancreatic cancer cells via both IL‐1α and HGF signaling pathways. J. Surg. Oncol. 2010;102:469–477. © 2010 Wiley‐Liss, Inc.
Prognostic value of the sixth edition of the UICC's TNM classification and stage grouping for oral cancer
Authors: Kreppel Matthias , Eich Hans Theodor , Kübler Alexander , Zöller Joachim E. , Scheer Martin 
Published: April 2010

AbstractBackgroundCarcinoma of the oral cavity is classified according to the TNM staging system of the UICC. The staging system is under continuous revision. The aim of our study was to assess the prognostic value of the UICC sixth edition for oral cancer, which was established in 2003.MethodsThree‐hundred treatment‐naive patients with oral squamous cell carcinoma (OSCC) of stages I–IVb were reviewed retrospectively. Patients with stage‐I disease were treated solely surgically, and patients with stage II–IVb received a multimodal treatment. Overall survival was plotted by Kaplan–Meier analysis. Prognostic factors were identified through univariate and multivariate analysis.ResultsUnivariate analysis showed a significant impact of T stage (P = 0.009), N stage (P < 0.001), and UICC stage (P < 0.001) on overall survival. However, no statistical differences were observed between stages T4a and T4b (P = 0.176) and UICC stages IVa and IVb (P = 0.306).ConclusionsT stage, N stage, and UICC stage grouping are good predictors of overall survival in patients with OSCC. Neither the division of stage T4 into T4a and T4b in the sixth edition nor the split of stage IV into IVa and IVb showed significant differences in overall survival between the subgroups. J. Surg. Oncol. 2010;102:443–449. © 2010 Wiley‐Liss, Inc.
Local recurrence rate of fine‐needle aspiration biopsy in primary high‐grade sarcomas
Authors: Kaffenberger Benjamin H. , Wakely Paul E. , Mayerson Joel L. 
Published: April 2010

AbstractBackgroundFine‐needle aspiration biopsy (FNAB) is an emerging technique for diagnosis of bone and soft tissue lesions. While multiple studies have demonstrated efficacy, cost‐effectiveness, and convenience, none have attempted to determine if the modality leads to an increased rate of local recurrence. Our objective was to determine whether FNAB could be linked to an increased rate of local recurrence.MethodsWe reviewed a database containing records of 388 patients who underwent FNAB without surgical biopsy tract excision between September 2002 and December 2006 in the orthopedics department at our institution. After application of rigid criteria to minimize confounding variables, 20 patients were retrospectively examined for local recurrence and distant metastasis.ResultsIn this cohort, no local recurrences were seen over a mean follow‐up of 45 months. Fifteen percent of our patients developed one or more distant metastases over the same time interval. Our experience offers preliminary evidence for the safety of this method.ConclusionsWhile further studies are needed, our data combined with already reported studies on efficacy, cost‐effectiveness, and convenience are encouraging for expanding the use of FNAB in the diagnosis of bone and soft tissue tumors. J. Surg. Oncol. 2010; 101:618–621. © 2010 Wiley‐Liss, Inc.
Risk‐reducing surgery in FAP: Role for surgeons beyond the incision
Authors: Neuman H.B. , Robbins L. , Duarte J. , Charlson M.E. , Weiser M.R. , Guillem J.G. , Wong W.D. , Temple L.K. 
Published: April 2010

AbstractBackgroundAlthough primary therapy in familial adenomatous polyposis (FAP) is surgical, little is known about patients' surgical decision‐making experience. The objective was to explore the decision‐making process surrounding risk‐reducing surgery in FAP using qualitative methodology.MethodsIn‐depth, semi‐structured interviews with 14 FAP patients and 11 healthcare providers with experience caring for FAP patients were conducted. Using grounded theory, line‐by‐line content analysis identified categories from which themes describing patients' experiences emerged; analysis continued until data saturation.ResultsMedian age at surgery was 23 (7–37) years; at interview 41 (19–74) years. Two patients underwent surgery secondary to cancer, the remainder for risk‐reduction. Content experts included colorectal surgeons (3), geneticists (2), gastroenterologists (3), nurses (3).Three themes emerged: Information: Family was the primary information source, and patients' level of information varied. The importance of up‐front information was emphasized. Influences on decision‐making: Influential factors included family experiences, youth, emotional state, support, and decision‐making role. Although patients often sought opinions, most (12/14) wanted an active/shared role in decision‐making. Life after surgery: Patients described surgery as the “easy part,” emphasizing the need for long‐term relationships with care providers.ConclusionsDecisions surrounding risk‐reducing surgery in FAP are unique. A decision support tool may facilitate decision‐making, better preparing patients for life after surgery. J. Surg. Oncol. 2010; 101:570–576. © 2010 Wiley‐Liss, Inc.
Optimal assessment of residual disease after neo‐adjuvant therapy for locally advanced and inflammatory breast cancer—clinical examination, mammography, or magnetic resonance imaging?
Authors: Wright F.C. , Zubovits J. , Gardner S. , Fitzgerald B. , Clemons M. , Quan M.L. , Causer P. 
Published: April 2010

AbstractPurposeAccurate assessment of residual disease after neo‐adjuvant chemotherapy (NEC) for women with locally advanced and inflammatory breast cancer (LABC) is critical for planning surgery. The study's purpose was to prospectively determine the optimal method (clinical examination (CE), mammogram (MG), and magnetic resonance imaging (MRI)) for assessing residual disease after NEC for women with LABC.MethodsWomen with LABC who received NEC and surgery were enrolled. Patient demographics, tumor size as measured by CE, MG, and MRI both before and after NEC, and final pathologic size of tumor were collected. Response to NEC was calculated using RECIST criteria. Paired t‐tests and the Pearson correlation were used to compare tumor size on CE, MG, MRI, and final pathology.ResultsForty‐eight women with 50 LABC were recruited. Mean pre‐NEC tumor size was 8.2, 5.1, and 6.2 cm on CE, MG, and MRI. Mean post‐NEC tumor size was 2.4, 4.3, 3.9, and 3.6 cm on CE, MG, MRI, and final pathology. The Pearson correlation co‐efficient between post‐NEC measurements and pathology was 0.63 (CE), 0.15 (MG), and 0.49 (MRI).ConclusionWe found that there was limited correlation between the extent of residual disease after NEC for patients with LABC as assessed by CE, MG, and MRI as compared to final pathology. J. Surg. Oncol. 2010; 101:604–610. © 2010 Wiley‐Liss, Inc.
Posttraumatic stress reactions in siblings after mutual disaster: Relevance of family factors
Authors: Nygaard Egil , Jensen Tine K. , Dyb Grete 
Published: April 2010

AbstractIn this study, the importance of family factors in the development of posttraumatic stress reactions in children after trauma is studied by comparing siblings and nonsiblings who experienced the tsunami in Southeast Asia in 2004 as tourists. Thirty‐eight sibling pairs aged 6–17 years were interviewed using the UCLA Posttraumatic Stress Disorder Reaction Index. The sibling differences were similar to differences found in randomly selected children in the same sample, indicating that family influences may not be as important as anticipated. The results are an important contribution to our understanding of what contributes to and influences the development of posttrauma reactions in children. They also suggest the importance of conducting individual assessments even after mutually experienced trauma.
The efficacy of early propranolol administration at reducing PTSD symptoms in pediatric injury patients: A pilot study
Authors: Nugent Nicole R. , Christopher Norman C. , Crow John P. , Browne Lorin , Ostrowski Sarah , Delahanty Douglas L. 
Published: April 2010

AbstractInitial research supports the use of propranolol to prevent posttraumatic stress disorder (PTSD); research has not examined pharmacological prevention for children. Twenty‐nine injury patients (ages 10–18 years old) at risk for PTSD were randomized to a double‐blind 10‐day trial of propranolol or placebo initiated within 12 hours postadmission. Six‐week PTSD symptoms and heart rate were assessed. Although intent‐to‐treat analyses revealed no group differences, findings supported a significant interaction between gender and treatment in medication‐adherent participants, ΔR2 = .21. Whereas girls receiving propranolol reported more PTSD symptoms relative to girls receiving placebo, ΔR2 = .44, boys receiving propranolol showed a nonsignificant trend toward fewer PTSD symptoms than boys receiving placebo, ΔR2 = .32. Findings inform gender differences regarding pharmacological PTSD prevention in youth.
Effect of porosity of phosphate coating on corrosion resistance of galvanized and phosphated steels Part II: Evaluation of corrosion resistance
Authors: Teixeira C. H. S. B. , Alvarenga E. A. , Vasconcelos W. L. , Lins V. F. C. 
Published: April 2010

AbstractThe effect of porosity of phosphate coatings on the corrosion resistance of ungalvanized (UG), electrogalvanized, and hot dip galvanized steels is evaluated in this study. The corrosion resistance of phosphatized and painted steel is related to the integrity and continuity of phosphate and paint layers, and pores in the phosphate layer affect the corrosion resistance of material. The porosity of the phosphate coating was evaluated by using the cathodic polarization electrochemical test. To evaluate the corrosion resistance of the phosphatized and painted steels, they were submitted to accelerated corrosion tests. As was expected, the creepback from the scribe increased with the increase in porosity. This behavior was evident for UG steel, but less evident for galvanized steels due to cathodic protection and/or barrier effect of the zinc coating.
Corrosion resistance of Ni‐50Cr HVOF coatings on 310S alloy substrates in a metal dusting atmosphere
Authors: Saaedi J. , Arabi H. , Coyle T. W. , Mirdamadi S. , Ghorbani H. 
Published: April 2010

AbstractMetal dusting attack has been examined after three 168 h cycles on two Ni‐50Cr coatings with different microstructures deposited on 310S alloy substrates by the high velocity oxy‐fuel (HVOF) thermal‐spray process. Metal dusting in uncoated 310S alloy specimens was found to be still in the initiation stage after 504 h of exposure in the 50H2:50CO gas environment at 620 °C. Dense Ni‐50Cr coatings offered suitable resistance to metal dusting. Metal dusting was observed in the 310S substrates adjacent to pores at the interface between the substrate and a porous Ni‐50Cr coating. The porosity present in the as‐deposited coatings was shown to introduce a large variability into coating performance. Carbon formed by decomposition of the gaseous species accumulated in the surface pores and resulted in the dislodgement of surface splats due to stresses generated by the volume changes. When the corrosive gas atmosphere was able to penetrate through the interconnected pores and reach the coating–substrate interface, the 310S substrate was carburized, metal dusting attack occurred, and the resulting formation of coke in the pores led to local failure of the coating.
Integral diagnostic in the failure causes of external corrosion of a natural gas transport pipeline
Authors: Mora‐Mendoza J. L. , Saucedo‐Robles L. C. , Rodríguez‐Clemente H. , González‐Núñez M. A. , Zavala‐Olivares G. , Hernández‐Gayosso M. J. 
Published: April 2010

AbstractThe objective of this study consisted in investigating the possible causes which give rise to the presence of low wall pipe thicknesses on a 16″ natural gas transport pipeline, even though during the last 12‐year period cathodic protection (CP) potentials were kept in the protection range at which external corrosion should not occur. Results from in‐line inspection from a 16″ natural gas transport pipeline showed 46 indications with more than 80% wall thickness lost due to external corrosion in the second segment of the pipeline. Direct inspection at the indication locations, review of the CP system performance, pipeline maintenance programs and studies, allowed to make an integral diagnostic where it was found out that the main cause of external corrosion was an inappropriate coating application since the pipeline construction, this situation has originated the increase of CP shielding effects through time.
Polarization resistance measurements of bars embedded in concrete with different chloride concentrations: EIS and DC comparison
Authors: Martínez I. , Andrade C. 
Published: April 2010

AbstractThe experimental conditions for corrosion rate measurements of reinforcement by means of the polarization resistance technique, Rp, in order to obtain reliable values (in accordance with the gravimetric losses simultaneously measured) must consider some factors as are: the need to subtract ohmic drop generated by the high resistivity of the concrete, the need to wait a certain time after application of the current, the use of a certain sweep rate in order to obtain a quasi‐steady‐state value of the conjugated variable (potential/current), the need to avoid the overlapping with other processes, and the need to use a correct B value in Stern formula. These experimental requirements should be optimized for the individual kinetic of each system. From time to time several papers are published wondering whether Rp measurements in concrete are reliable. Present paper extends the study of the experimental conditions influence in the Rp determination in order to look more in detail to the accuracy of Rp technique. Several sweep rates in potentiodynamic tests, different waiting times with galvanostatic and potentiostatic pulses and different frequencies in electrochemical impedance spectroscopy, EIS, were tested in order to compare the most suitable parameters that provide correct values of the corrosion rate, Icorr.
Polymerization of Cyclosiloxanes by Means of Triflic Acid and Metal Triflates
Authors: Yashiro Takao , Kricheldorf Hans R. , Schwarz Gert 
Published: April 2010

AbstractHexamethylcyclotrisiloxane (D3), octamethylcyclotetrasiloxane (D4), and decamethylcyclopentasiloxane (D5) were equilibrated with potassium tert‐butoxide or triflic acid in bulk at 100 °C to elaborate the 1H NMR and 13C NMR spectra, SEC elution curve, and MALDI‐TOF (MT) mass spectrum of a fully equilibrated poly(dimethylsiloxane). Surprisingly, triflic acid did not effect complete equilibration (even after 360 h), seemingly because cleavage of Si–C bonds eliminates the acidic proton. Large amounts of D4 and D5 together with small amount of D6 were formed in the early stage of the polymerization in contrast to potassium alkoxide‐catalyzed polymerizations. The usefulness of numerous metal triflates as polymerization catalysts of D3 was explored, and only the most acidic ones were active. Bismuth and hafnium triflate catalyzed a polymerization mechanism similar to that of triflic acid but were more active despite their poor solubility. BiCl3 and HfCl4 were considerably less reactive and the polymerization kinetics were quite different from those of the metal triflate catalyzed polymerizations. The decisive role of acidic protons was revealed by addition of a proton scavenger. Bismuth triflate proved to be an interesting and useful catalyst because it combines the highest activity with poor solubility and low toxicity.magnified image
Emotional Information Management: Concept development and measurement in public service announcements
Authors: Taute Harry A. , Huhmann Bruce A. , Thakur Ramendra 
Published: April 2010

AbstractResearch on emotion as information in persuasive communication and ad response has created a need for a measure of individual abilities in the management of emotional information. Previous measures (e.g., emotional intelligence measures) lack adequate validity and reliability for use in persuasion and advertising contexts. Four studies iteratively refine a parsimonious Emotional Information Management scale that corresponds to theoretical dimensions of the construct and interrelationships between those dimensions—recognition of emotion, regulatory processes of optimistic utilization and management of emotions, as well as cognitive and emotional empathy. Reliability and construct validity are demonstrated, and scale norms are established. Although gender does not affect recognition of emotions or cognitive empathy, females exhibit greater emotional empathy ability, whereas males exhibit greater emotion regulation ability. Measuring emotional information management should contribute to greater understanding of responses to emotion‐laden or emotion‐eliciting persuasive communication (e.g., public service announcements). ©2010 Wiley Periodicals, Inc.
Hippocampal, caudate, and ventricular changes in Parkinson's disease with and without dementia
Authors: Apostolova Liana G. , Beyer Mona , Green Amity E. , Hwang Kristy S. , Morra Jonathan H. , Chou Yi‐Yu , Avedissian Christina , Aarsland Dag , Janvin Carmen C. , Larsen Jan P. , Cummings Jeffrey L. , Thompson Paul M. 
Published: April 2010

AbstractParkinson's disease (PD) has been associated with mild cognitive impairment (PDMCI) and with dementia (PDD). Using radial distance mapping, we studied the 3D structural and volumetric differences between the hippocampi, caudates, and lateral ventricles in 20 cognitively normal elderly (NC), 12 cognitively normal PD (PDND), 8 PDMCI, and 15 PDD subjects and examined the associations between these structures and Unified Parkinson's Disease Rating Scale (UPDRS) Part III:motor subscale and Mini‐Mental State Examination (MMSE) performance. There were no hippocampal differences between the groups. 3D caudate statistical maps demonstrated significant left medial and lateral and right medial atrophy in the PDD vs. NC, and right medial and lateral caudate atrophy in PDD vs. PDND. PDMCI showed trend‐level significant left lateral caudate atrophy vs. NC. Both left and right ventricles were significantly larger in PDD relative to the NC and PDND with posterior (body/occipital horn) predominance. The magnitude of regionally significant between‐group differences in radial distance ranged between 20–30% for caudate and 5–20% for ventricles. UPDRS Part III:motor subscale score correlated with ventricular enlargement. MMSE showed significant correlation with expansion of the posterior lateral ventricles and trend‐level significant correlation with caudate head atrophy. Cognitive decline in PD is associated with anterior caudate atrophy and ventricular enlargement. © 2010 Movement Disorder Society
The estimated benefits of vitamin D for Germany
Authors: Zittermann A. 
Published: April 2010

AbstractThis article gives an overview of the vitamin D status in Germany, provides evidence for an independent association of vitamin D deficiency with various chronic diseases, and discusses preventive measures for improving vitamin D status in Germany. The prevalence of vitamin D insufficiency is 40–45% in the general German population. An additional 15–30% are vitamin D deficient. Vitamin D can prevent falls and osteoporotic fractures in older people. There is also accumulating evidence that vitamin D may prevent excess mortality and may probably prevent some chronic diseases that occur in early life such as type 1 diabetes and multiple sclerosis. Adherence to present sun safety policy (avoidance of the sun between 11 am and 3 pm) and dietary recommendations (5–10 μg daily for adults) would, however, definitively lead to vitamin D deficiency. The estimated cost saving effect of improving vitamin D status in Germany might be up to 37.5 billion € annually. It should be the goal of nutrition and medical societies to erase vitamin D deficiency in Germany within the next 5–10 years. To achieve this goal, the daily production of at least 25 μg of vitamin D in the skin or an equivalent oral intake should be guaranteed.