bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluation of a self-reported G8 screening tool on Epic MyChart for older patients with cancer.
Authors: Wen Kuang-Yi , Swartz Kristine , Zhan Tingting , MacKenzie Amy R. , Chapman Andrew E. 
Published: May 2024

e13766 Background: The Geriatric 8 (G8) is a screening tool validated for cancer patients to identify those in need of a comprehensive geriatric assessment (CGA). It evaluates eight domains encompassing mobility, polypharmacy, age, and self-rated health. The existing original-G8 requires administration by a healthcare professional, limiting its accessibility and practicality. An electronic, patient-reported version could broaden its reach, enhancing care coordination. This study focuses on the implementation and evaluation of a self-reported G8 tool on Epic MyChart and its alignment with the original-G8. Methods: The MyChart-G8 underwent adaptation from the original-G8, retaining all domains while optimizing questions for patient self-completion and adhering to health communication design principles. We introduced MyChart-G8 across our Jefferson health system for all patients aged ≥ 65 with a new cancer diagnosis. For a subset of patients, an oncology nurse or medical assistant also administered the original G8 during the new patient visit rooming process. Agreement between MyChart-G8 and original-G8 for individual items was measured using Kappa statistics. Diagnostic accuracy of MyChart-G8 compared to the original-G8 was also assessed. Results: Our cohort comprised 203 older cancer patients who completed both MyChart-G8 and the original-G8. The frequency of abnormal scores (≤14) for the original-G8 and MyChart-G8 was 40.0% and 67.7%, respectively. Discrepancies between the two tools were partly attributed to less than moderate agreement for three individual items: neuropsychological problems (Kappa 0.15), BMI (Kappa 0.27), and self-rated health (Kappa 0.31). A MyChart-G8 cutoff of 14.5 demonstrated the best balance of sensitivity (0.86 ± 0.13) and specificity (0.57 ± 0.06) when compared to the original G8. Conclusions: The incorporation of self-reported G8 assessments into Epic MyChart is feasible and implementable. Persistent challenges arise in accurately assessing self-reported problems among older adult cancer patients in the electronic format, potentially resulting in MyChart over-flagging abnormalities. The introduction of the Practical Geriatric Assessment (PGA) presents an opportunity to streamline the CGA. By subsequently conducting a PGA for individuals identified as vulnerable through the MyChart G8, we can confirm frailty domains, inform treatment decisions, and address impairments through targeted interventions. This integrated, stepped-up assessment approach holds significant potential to optimize resource utilization, enhance patient engagement, and tailor individualized treatments, ultimately with the goal of maximizing treatment outcomes. The Sidney Kimmel Cancer Center is in the process of developing a decentralized model of PGA using MyChart G8 as a step-up approach across the Jefferson Health enterprise.
Paramedical staffs' perception of their role during the continuum of care from detection to treatment in nursing homes: Results of the ONCOPAD-Pre survey.
Authors: Falandry Claire , Tavernon Charlène , Bret Judith , Simeone Arnaud 
Published: May 2024

e13768 Background: Prevalence of cancer in nursing homes (NH) increases. ONCOPAD is a 4-step program dedicated to identifying and acting on educational needs, cultural and ethical barriers associated with cancer treatment in NH. The program included a scoping review (step 1), semi-directive interviews with care providers (step 2) designed to identify the major topics to be included in a tailored intervention and evaluated before and after it. Here we report the results of the survey before the intervention. Methods: Questions were mainly presented as 7-point Likert scales and classified into 6 sections: interviewee’s description, detection phase, treatment phase, relations and communication at work, ethical questioning, continuing education. Statistical analyses included descriptive statistics, exploratory factorial analyses, testing of model sphericity and sampling adequation. Results: From 06/2022 to 03/2023, 65 participants (median age 41 years; females: 84.6%) completed the questionnaire; 40.0% were nurses, 35.4% nurse assistants; 87.7% were full-time employees, and 73.8% were post holder. Interviewees considered their role as important at the detection stage (mean 4.82), to inform the physician (5.58) and their colleagues (5.45), their role during the decisional process (4.40) and to inform the patient on his diagnosis (4.05) were perceived as less important; organizational problems (lack of staff, time, facilities) could impede this stage. Factors perceived important for treatment decision were related to the patient (physical performance, cognition, age), his opinion (4.49), the opinion of his family (4.38), of his physician (5.17) and less to the paramedical team (4.02). The decision to pursue was mainly focused on care: pain relief (5.48), detection of clinical and psychological signs (5.18); the organizational barriers were perceived as major as well. Relations and communication at work, both internal and external to the institutions, were perceived as poor quality; 8 (12.3%) of the interviewees even skipped this section. The ethical questioning was permanent and homogeneous. Considering education, the interviewees felt insufficiently trained and the preferred model for training was short sequences integrated into daily work schedules; coordinating physicians appear as good mediators for such training courses. Conclusions: In this survey, paramedical staffs perceived their role as important during both detection and treatment of cancers, focusing more on care than cure; however, organizational constraints and poor quality of internal and external relations, and communication appear as major barriers in the completion of their role. Educational intervention should be tailored, favoring short sequences integrated into daily work schedules, coordinating physicians appear as good mediators for improvement in the future.
Inflammatory biomarkers and frailty transitions in older adults with cancer: Findings from a national cohort study.
Authors: Zhou Weijiao , Pu Junlan , Cho Youmin 
Published: May 2024

e13772 Background: Approximately 67% of cancer survivors were aged 65 or older in the U.S.; they face a heightened risk of frailty, as both cancer and anti-cancer treatment impose additional stressors on the older adults’ physiological reserves. Inflammatory biomarkers such as serum C-reactive protein (CRP) and Interleukin-6 (IL-6) levels were associated with frailty. However, the role of inflammatory biomarkers on the transitions of frailty states remains unclear. This study aimed to describe transitions between frailty states and death and quantify the predictive effect of inflammatory biomarkers on transitions. Methods: We used data from the National Health and Aging Trends Study (NHATS) from 2017 to 2022. A total of 1,219 older cancer survivors (>67 years) were included. Frailty was assessed annually using the Fried Frailty Phenotype (exhaustion, low physical activity, shrinking, low walking speed, and weakness) to categorize participants as “non-frail,” “pre-frail,” and “frail.” Inflammatory biomarkers were obtained via dried blood spots at baseline (2017). Plasma-equivalent values of CRP and IL-6 were used. Covariates included sex, age category, race, education level, marital status, obesity, and number of comorbidities. We defined four states that included three frailty states (non-frail, pre-frail, and frail) and an absorbing state of death. The multi-state Markov models were performed to capture possible transitions between frailty states and examine the effect of CRP and IL-6 on the five main transitions between states (non-frail to pre-frail, pre-frail to non-frail, pre-frail to frail, frail to pre-frail, frail to death). Results: At baseline, 25.27% were non-frail, 52.34% were pre-frail, and 22.40% were frail. During the follow-up time of 5 years, 1,396 transitions were observed, with 950 (68.05%) progressions (or to death) and 446 (31.95%) reversals. For participants who were non-frail, they were highly likely to develop pre-frailty (transition intensity=0.63). For participants with pre-frailty, progression to frailty was a little more likely than recovery to non-frailty (0.25 vs 0.21). Once entering the frail state, the likelihood of death outweighed that of recovery (0.30 vs 0.28). A higher level of CRP or IL-6 was associated with frailty progression (non-frail to pre-frail and frail to death), while a lower level of CRP or IL-6 was associated with recovery of frailty (pre-frail to non-frail and frail to pre-frail). Conclusions: This study is the first to investigate the longitudinal relationship between inflammatory biomarkers and frailty transitions in older cancer survivors using a nationally representative survey dataset. Our findings outlined potential transitions between frailty states and death, highlighting the role of elevated serum CRP and IL-6 levels on the increased risk of frailty progression and reduced risk of frailty recovery over 5 years.
Neoadjuvant dalpiciclib, exemestane, and goserelin in premenopausal women with HR-positive, HER2-negative breast cancer: A prospective, multicenter, randomized two-group, non-controlled phase 2 clinical trial.
Authors: Yang Zhengjun , Wang Xin , Chen Aoxiang , Meng Ran , Zhao Ying , Liu Hong , Ge Jie , Huang Ruixue , Bai Jianping , Cao Xucheng 
Published: May 2024

TPS625 Background: The combination of CDK4/6 inhibitors (CDK4/6i) with endocrine therapy has significantly improved progression-free survival and overall survival in patients with HR-positive, HER2-negative advanced breast cancer (BC), revolutionizing the treatment landscape. However, previous CDK4/6i neoadjuvant studies have predominantly focused on postmenopausal populations, leaving a gap in preoperative treatment for early HR-positive, HER2-negative premenopausal BC patients. Therefore, the present trial is conducted to investigate the efficacy of dalpiciclib, exemestane and goserelin as neoadjuvant therapy in premenopausal women with HR-positive, HER2-negative BC. Methods: This is a multicenter, randomized two-group, non-controlled phase 2 clinical trial. Key eligibility criteria include: Patients aged 18 years or older with no prior treatment, an ECOG performance status of 0-1, at least 1 measurable lesion, and clinical stage II-III HR-positive, HER2-negative premenopausal invasive BC. Initially, all enrolled patients will receive two cycles of treatment with docetaxel, doxorubicin, and cyclophosphamide (TAC). Subsequently, patients with complete response (CR) or partial response (PR) will receive an additional four cycles of TAC, whereas patients with progressive disease (PD) will undergo surgery or treatment options decided upon by the investigators. Those with stable disease (SD) will be randomly assigned 1:1 to either an experimental group receiving 16 weeks of dalpiciclib, exemestane, and goserelin (dalpiciclib: 125 mg daily for 21 days followed by 7 days off, exemestane: 25 mg daily for 28 days, goserelin: 3.6 mg every 28 days) or a standard chemotherapy group receiving four more cycles of TAC. Treatment response is assessed according to RECIST 1.1 criteria. Surgery will be performed after completion of the planned neoadjuvant treatment, followed by radiation therapy and systemic treatment according to local guidelines or the investigators' choices. The study's primary endpoint is the objective response rate (ORR) of the experimental group. Secondary endpoints include the ORR, residual cancer burden, preoperative endocrine prognostic index, event-free survival, and safety of both. Using Simon's two-stage optimal design and assuming a 40% response rate as desirable in the experimental group, at least 13 responses among a total of 43 patients were required to meet the primary endpoint. The trial will be terminated if fewer than 3 patients respond in the first stage. Considering an 80% SD rate post two neoadjuvant TAC cycles and a 10% attrition, the sample size was ultimately set at 119. The trial is actively recruiting. Clinical trial information: NCT06009627 .
Level of knowledge of prevention of blood-borne infectious diseases among Master’s degree students of nursing
Authors: Sierpińska Lidia , Skowronek Katarzyna , Jedynak Anna 
Published: May 2024

Introduction. Blood-borne infections are a serious problem among medical staff, especially nursing staff, because nurses have the most frequent contact with patients. As future employees of health care, students of nursing are exposed to a number of hazardous factors. Work with patients of unknown serological status (during practical classes and apprenticeships) is associated with the risk of infection with various pathogens.
Objective. The aim of the study was recognition of the level of knowledge concerning prevention of blood-borne infectious diseases among Master’s degree students of nursing.
Material and Methods. The study was conducted in the second half of 2022 among 104 Master’s degree students of nursing, who were educated at the Radom School in Radom, by the method of a diagnostic survey, using an author-constructed questionnaire.
Results. The majority of the examined students (96.2%) knew what diseases are transmitted through blood. More than a half of respondents (63.5%) evaluated their level of knowledge about blood-borne diseases as mediocre, and 19.2% - as low. A part of respondents (67.3%) had knowledge that trace amounts of blood are enough to cause infection with blood-borne diseases. All students in the study knew the main methods of prevention of infections transmitted via blood, and the deficit of knowledge concerned proper use of personal protection equipment (5.8%) and the observance of the procedure to be followed in the event of occupational exposure (3.8%). A large group of respondents (82.7%-100.0%) knew various risk factors of infection with blood-borne diseases. The majority of respondents (88.5%) knew that there is an effective vaccine against hepatitis B, but 43.3% of the students in the study did not know the main symptoms of infection with HBV. Students most often knew (90.4%) how to diagnose infection with HCV – anti-HCV test for the presence of antibodies against hepatitis C virus in blood; however, 26.9% of respondents were not aware that there is no vaccine against hepatitis C. The majority of the examined students (84.7%) knew early symptoms of infection with HIV, while the remainder had a deficit of knowledge in this area. A large group of respondents (82.0%-94.0%) knew various risk factors of infection with HIV.
Conclusions. Students of nursing should be motivated to expand their knowledge concerning prevention of blood-borne diseases, observance of the principles of personal protection, prevention of occupational exposure, and proper post-exposure prophylaxis.
"a antropologia da infância chegou para ficar": entrevista com david lancy
Authors: Lancy David , Medaets Chantal , Tebet Gabriela , Pires Flávia 
Published: May 2024

O texto discute a consolidação do campo da antropologia da infância a partir de um diálogo com David Lancy, professor emérito de antropologia na Universidade do Estado de Utah, Estados Unidos, e uma das figuras-chave da institucionalização do campo naquele país. A partir de uma entrevista com Lancy na ocasião do lançamento da terceira edição de seu livro The Anthropology of Childhood, apresentamos as principais contribuições deste autor a um público lusófono e discutimos temas chave para os estudos da infância, como os usos da noção de agência, bebês, a variabilidade cultural das categorias de idade, além da contribuição da antropologia para as pesquisas sobre infância, parentalidade e educação. Para Lancy, a antropologia da infância dá visibilidade a compreensões alternativas, em relação à psicologia do desenvolvimento infantil, sobre a infância e sobre processos de aprendizagem, trazendo novas questões e novas perspectivas. Com base num amplo levantamento de pesquisas etnográficas, o autor afirma a significativa quantidade de registros feitos por antropólogos sobre as vidas de crianças em diferentes culturas, enfatizando as distinções entre, de um lado, as infâncias de povos originários e tradicionais e, de um outro lado, infâncias ocidentais e urbanas, que ele sugere agrupar, seguindo uma denominação cada vez mais frequente nos Estados Unidos, como sociedades “WEIRD” [extraño], um acrônimo para “Western, Educated, Industrialized, Rich and Democratic Societies”. Nesta entrevista, Lancy ressalta que os trabalhos antropológicos sobre infância em povos originários ou povos tradicionais, quando bem conduzidos, possuem o potencial de produzir um efeito de grande respeito e legitimidade às formas de pensar sobre a infância e educação desses povos.
Optical micro/nanofiber enabled wearable accelerometer
Authors: Yu Wen , Zhang Lei 
Published: May 2024

Highly sensitive and miniaturized accelerometers are of importance in many areas. Herein, an optical micro/nanofiber (MNF) enabled accelerometer is proposed. The structural parameters of the MNF accelerometer are optimized based on theoretical simulation. The accelerometer shows excellent linear relationship between displacement and force in a force range of 0–40 nN and achieves a minimum detectable acceleration of 0.15m/s2. For vibration sensing, the natural frequency of the sensor can be as high as 753 Hz; the vibrations of the tuning fork and human arm are recorded with high fidelity.
Low-modal-crosstalk doped-fiber amplifiers in few-mode-fiber-based systems
Authors: Huang Shuailuo , Shen Lei , Qiao Gang , Ding Yuanpeng , Gao Yuyang , Cui Jian , Zhu Baolong , Liu Siyuan , Zuo Mingqing , Zhu Jinglong , Zhang Lei , Luo Jie , He Yongqi , Chen Zhangyuan , Li Juhao 
Published: May 2024

Independent light propagation through one or multiple modes is commonly considered as a basic demand for mode manipulation in few-mode fiber (FMF)- or multimode fiber (MMF)-based optical systems such as transmission links, optical fiber lasers, or distributed optical fiber sensors. However, the insertion of doped-fiber amplifiers always kills the entire effort by inducing significant modal crosstalk. In this paper, we propose the design of doped-fiber amplifiers in FMF-based systems adopting identical multiple-ring-core (MRC) index profiles for both passive and doped fibers to achieve low modal crosstalk. We develop the direct-glass-transition (DGT) modified chemical vapor deposition (MCVD) processing for precise fabrication of few-mode erbium-doped fibers (FM-EDFs) with MRC profiles of both refractive index and erbium-ion doping distribution. Then, a few-mode erbium-doped-fiber amplifier (FM-EDFA) with a maximum gain of 26.08 dB and differential modal gain (DMG) of 2.3 dB is realized based on fabricated FM-EDF matched with a transmission FMF supporting four linearly polarized (LP) modes. With the insertion of the FM-EDFA, 60 + 60 km simultaneous LP01/LP11/LP21/LP02 transmission without inter-modal multiple-input multiple-output digital signal processing (MIMO-DSP) is successfully demonstrated. The proposed design of low-modal-crosstalk doped-fiber amplifiers provides, to our knowledge, new insights into mode manipulation methods in various applications.
The one-minute sit-to-stand-test performance is associated with health-related quality of life in patients with pulmonary hypertension
Authors: Kronberger Christina , Willixhofer Robin , Mousavi Roya Anahita , Grzeda Mariusz Tadeusz , Litschauer Brigitte , Krall Christoph , Badr Eslam Roza 
Published: May 2024

Introduction
Patients with pulmonary hypertension (PH) have an impaired functional capacity and poor health-related quality of life (HRQoL). The one-minute sit-to-stand test (1-min STST) can be used for the assessment of functional capacity.

Aims
Our aim was to evaluate the 1-min STST performance and its association with patient-reported HRQoL in patients with PH.

Methods
We prospectively assessed functional capacity in 98 PH patients (mean age 66 ± 15 years, 55% female) using the 1-min STST. Patients had to stand up and sit down from a chair as many times as possible within one minute. Patients’ HRQoL was evaluated with the Cambridge Pulmonary Hypertension Outcome Review (CAMPHOR) questionnaire, which consists of the three subcategories symptoms, activities and quality of life (QoL).

Results
We observed a significant correlation of the 1-min STST performance with all HRQoL subcategories assessed with the CAMPHOR questionnaire: A lower number of 1-min STST repetitions correlated with more symptoms (rs = -.398, p < .001), worse functioning (rs = -.551, p < .001) and a decreased QoL (rs = -.407, p < .001). Furthermore, in the multivariable linear regression analysis, adjusted for age, sex, body mass index (BMI) and mean pulmonary artery pressure (mPAP), lower 1-min STST performance was an independent predictor for worse symptoms (est. β = -0.112, p = .003), activities (est. β = -0.198, p < .001) and QoL (est. β = -0.130, p < .001) assessed with the CAMPHOR questionnaire.

Conclusion
Our results indicate that regardless of age, sex, BMI and mPAP the 1-min STST performance is associated with all CAMPHOR HRQoL subcategories in patients with PH. Therefore, the 1-min STST performance might be a new option to assess functional capacity correlated to HRQoL in patients with PH.
Who follows through? Different factors predict initial commitment vs. Following through in a national survey of organ donor registration
Authors: Yang Michelle Z. , Sheeran Paschal 
Published: May 2024

Objective
Little research has investigated factors that determine whether people falter in the face of an obstacle or successfully follow through on an initial commitment to act. We integrated multiple theories (the Reasoned Action Approach [RAA], Prototype Willingness Model, and anticipated regret theory) to test which factors predict initial commitment to register as an organ donor and to discover whether different factors predict initial commitment vs. following through with registration.

Methods
Participants from a nationally representative UK sample (N = 1,008) reported their beliefs about organ donation and indicated their decision to register. An obstacle that participants could not foresee was that they had to complete registration in a second survey 3 days after making their initial commitment.

Results
Findings showed that 14.8% of participants followed through, 19.7% demonstrated initial commitment, and 65.5% declined to register. Linear discriminant function analysis derived two functions that distinguished these registration patterns. The first function discriminated participants who declined to register from the other groups. The declined group had lower scores on RAA variables compared to their counterparts. The second function distinguished participants who made an initial commitment to register from those who followed through. Follow-through was associated with less anticipated negative affect, more favorable descriptive norms, and stronger identification with organ donors.

Conclusions
The present findings indicate that even modest friction leads to a large reduction in follow-through. Moreover, different factors influence initial commitment vs. following through. Whereas RAA variables predicted initial commitment, following through was a function of anticipated negative affect and social processes.