bluuebunny/crossref_metadata_2025_split huggingface dataset:
WONOEP 2022: Neurotechnology for the diagnosis of epilepsy
Authors: Wagstyl Konrad , Kobow Katja , Casillas‐Espinosa Pablo M. , Cole Andrew J. , Jiménez‐Jiménez Diego , Nariai Hiroki , Baulac Stéphanie , O'Brien Terence , Henshall David C. , Akman Ozlem , Sankar Raman , Galanopoulou Aristea S. , Auvin Stéphane 
Published: June 2024

AbstractEpilepsy's myriad causes and clinical presentations ensure that accurate diagnoses and targeted treatments remain a challenge. Advanced neurotechnologies are needed to better characterize individual patients across multiple modalities and analytical techniques. At the XVIth Workshop on Neurobiology of Epilepsy: Early Onset Epilepsies: Neurobiology and Novel Therapeutic Strategies (WONOEP 2022), the session on “advanced tools” highlighted a range of approaches, from molecular phenotyping of genetic epilepsy models and resected tissue samples to imaging‐guided localization of epileptogenic tissue for surgical resection of focal malformations. These tools integrate cutting edge research, clinical data acquisition, and advanced computational methods to leverage the rich information contained within increasingly large datasets. A number of common challenges and opportunities emerged, including the need for multidisciplinary collaboration, multimodal integration, potential ethical challenges, and the multistage path to clinical translation. Despite these challenges, advanced epilepsy neurotechnologies offer the potential to improve our understanding of the underlying causes of epilepsy and our capacity to provide patient‐specific treatment.
Nutrient composition, fermentation characteristics and mass balance of press juice and press cake obtained from biorefining of grass‐clover and red clover silage
Authors: Resch Reinhard , Terler Georg , Winter Manuel , Mandl Michael , Baldinger Lisa , Sweeney Joseph , McDonnell Kevin , Steinwidder Andreas 
Published: June 2024

AbstractBiorefining is seen as a potential method to produce protein‐rich feed for monogastric farm animals from grassland, which does not compete with human nutrition. Therefore, a new biorefinery facility was constructed and tested in this experiment by using silages from grass clover mixture and red clover. After biorefining, press juice was stored for further use while press cake was re‐ensiled. Samples from silage, press juice, fresh press cake and re‐ensiled press cake were analysed for nutrient composition, fermentation parameters, amino acids (AA) and biogenic amines (BA) concentrations. Furthermore, digestibility of silage and re‐ensiled press cake was tested in wethers. We found that press juice contained about 205 g crude protein (CP), more than 180 g crude ash and more than 130 g volatile organic compounds (VOC, all values per kg dry matter [DM]). Furthermore, press juice had an unfavourable AA ratio for use as a monogastric feed (methionine and cysteine were reduced). Forage type hardly affected nutritive value of press juice. Re‐ensiling of press cake was successful as a sufficient decrease of pH and VOC concentration was observed. Press cake had 26–36 g/kg DM lower CP content and 0.77–1.12 MJ/kg DM lower metabolisable energy content than silage with greater differences in red clover than in grass clover mixture. Press juice can be used as feed in monogastric animals, but its use is limited due to its low CP content and unfavourable AA profile. Press cake could be an appropriate feed for ruminants, especially dry cows or heifers.
Characteristics of freeze‐dried white cheese powder and utilisation in bread formulation
Authors: Konuk Takma Dilara , Ökay Utku , Güneş Ümmü 
Published: June 2024

SummaryFreeze‐dried white cheese powder was produced using WPI (Whey protein isolate) and CMC (carboxymethyl cellulose) and applied in bread production. The optimal formulation ratio of WPI and CMC in freeze‐dried white cheese powder was determined as 5% and 1% (w/w) based on powder properties. Quality characteristics of bread were examined by replacement of white flour with white cheese powder at 10%, 15% and 20%. The addition of CMC provided a significant increase in centrifugal stability (97.18%) and kinetic stability (97.25%) of white cheese emulsions. In powders, CMC reduced water activity, potentially contributing to quality preservation during shelf‐life. The powder with CMC indicated a lighter colour and incorporating the powder into bread formulations resulted in lower L* values and higher a* values compared to the control bread. Texture properties of bread were significantly affected by amount of the powder. The study indicated that white cheeses approaching expiration date can be used in the food industry by converting them into a value‐added product, white cheese powder, using the freeze‐drying technique.
Comparative detection of goat's milk casein through various enzyme‐linked immunosorbent assay (ELISA) approaches using caprine alpha‐S1 casein peptides and bovine casein polyclonal antibodies
Authors: Samsudin Nurul Izza Nabilah Mohd , Sukor Rashidah , Mohsin Aliah Zannierah , Saari Nazamid 
Published: June 2024

SummaryCasein causes allergic reactions in cow's milk protein allergy (CMPA) individuals. Casein can cross‐react with cows and goats. Hence, a rapid and highly specific technique is required for its detection. The study aims to evaluate and optimise multiple Enzyme‐Linked Immunosorbent Assay (ELISA) approaches for the detection of casein isolated from goat's milk. The study utilised and optimised various ELISA approaches, including direct, indirect and sandwich with various antibodies. Several parameters of ELISA including pre‐treatments of casein, blocking reagent, concentrations of antibodies and background signal were evaluated. The results showed that sandwich ELISA revealed a good signal‐to‐noise ratio at 1 mg mL−1. Indirect ELISA showed a higher signal‐to‐noise ratio without any heat treatment in comparison to the direct ELISA despite utilising an equivalent concentration (i.e., 10 μg mL−1) of goat's milk casein. The findings provide a theoretical foundation for obtaining a high signal‐to‐noise ratio for antigenicity studies of goat's milk casein to minimise its immunological response.
Chemical design of barium titanate thin films for nanophotonic devices
Authors: Zhu Minmin , Zhang Xianrong , Wei Can , Yi Xiaoyuan , Yang Dan , Zhang Haizhong , Wang Linghua 
Published: June 2024

AbstractHigh‐performance electro‐optic (EO) materials greatly enhance modulators and switches in various photonic applications. We investigate the evolution of the tolerance factor (t) and EO coefficient (rc) in A‐site and B‐site doped BaTiO3 (BT) thin films. Our analysis reveals that cation transmutation has a remarkable impact on their dielectric constant, spontaneous polarization, optical band gap, and EO coefficient. Notably, Pb‐doped BT samples exhibit an even higher rc value of 336.5 pm/V, representing a nearly 60% increase compared to pure BT and approximately 11 times larger than that of LiNbO3. This substantial improvement in EO performance can be attributed to enhanced local structural heterogeneity resulting from cation dopants. Furthermore, infusing dopants in BT also result in good structural uniformity and reliable EO performances, regardless of temperature and frequency. Our study offers valuable insights into doping engineering for obtaining functional perovskite oxides, enabling the development of power‐efficient, ultra‐compact integrated nanophotonic devices.
Effects of B′‐site configurational entropy on structure and microwave dielectric characteristics in Ba(B′1/3Nb″2/3)O3 complex perovskite ceramics
Authors: Guo Rui Ze , Yu Chen Xing , Ding Yi Han , Wang Xi , Zhu Xiao Li , Chen Xiang Ming 
Published: June 2024

AbstractBa[(Ca0.2Mg0.2Zn0.2Co0.2Ni0.2)1/3Nb2/3]O3 and Ba[(Mg0.25Zn0.25Co0.25Ni0.25)1/3Nb2/3]O3 perovskite single‐phase ceramics were synthesized by a solid‐state reaction method, and they were annealed at different temperatures in order to investigate the effect of B′‐site configurational entropy on phase stability, ordered domain structure and microwave dielectric characteristics. By comparing the B′‐site high‐entropy composition with B′‐site medium‐entropy and low‐entropy compositions, the entropy‐dominated phase‐stabilization effect and sluggish diffusion effect were observed in Ba[(Ca0.2Mg0.2Zn0.2Co0.2Ni0.2)1/3Nb2/3]O3. These effects enhanced the temperature stability of the B‐site 1:2 ordered structure. Ba[(Ca0.2Mg0.2Zn0.2Co0.2Ni0.2)1/3Nb2/3]O3 even reached a higher Qf value after annealing above the order‐disorder transition temperature (To‐d). This research extends the entropy regulation to ordered complex perovskite and provides a promising way to modify the performances of complex perovskite dielectric ceramics.
Dual process models of clinical reasoning: The central role of knowledge in diagnostic expertise
Authors: Norman Geoff , Pelaccia Thierry , Wyer Peter , Sherbino Jonathan 
Published: June 2024

AbstractRationaleResearch on diagnostic reasoning has been conducted for fifty years or more. There is growing consensus that there are two distinct processes involved in human diagnostic reasoning: System 1, a rapid retrieval of possible diagnostic hypotheses, largely automatic and based to a large part on experiential knowledge, and System 2, a slower, analytical, conscious application of formal knowledge to arrive at a diagnostic conclusion. However, within this broad framework, controversy and disagreement abound. In particular, many authors have suggested that the root cause of diagnostic errors is cognitive biases originating in System 1 and propose that educating learners about the types of cognitive biases and their impact on diagnosis would have a major influence on error reduction.Aims and ObjectivesIn the present paper, we take issue with these claims.MethodWe reviewed the literature to examine the extent to which this theoretical model is supported by the evidence.ResultsWe show that evidence derived from fundamental research in human cognition and studies in clinical medicine challenges the basic assumptions of this theory—that errors arise in System 1 processing as a consequence of cognitive biases, and are corrected by slow, deliberative analytical processing. We claim that, to the contrary, errors derive from both System 1 and System 2 reasoning, that they arise from lack of access to the appropriate knowledge, not from errors of processing, and that the two processes are not essential to the process of diagnostic reasoning.ConclusionsThe two processing modes are better understood as a consequence of the nature of the knowledge retrieved, not as independent processes.
Updated classification of the phylum Parabasalia
Authors: Boscaro Vittorio , James Erick R. , Fiorito Rebecca , del Campo Javier , Scheffrahn Rudolf H. , Keeling Patrick J. 
Published: June 2024

AbstractThe phylum Parabasalia includes very diverse single‐cell organisms that nevertheless share a distinctive set of morphological traits. Most are harmless or beneficial gut symbionts of animals, but some have turned into parasites in other body compartments, the most notorious example being Trichomonas vaginalis in humans. Parabasalians have garnered attention for their nutritional symbioses with termites, their modified anaerobic mitochondria (hydrogenosomes), their character evolution, and the wholly unique features of some species. The molecular revolution confirmed the monophyly of Parabasalia, but considerably changed our view of their internal relationships, prompting a comprehensive reclassification 14 years ago. This classification has remained authoritative for many subgroups despite a greatly expanded pool of available data, but the large number of species and sequences that have since come out allow for taxonomic refinements in certain lineages, which we undertake here. We aimed to introduce as little disruption as possible but at the same time ensure that most taxa are truly monophyletic, and that the larger clades are subdivided into meaningful units. In doing so, we also highlighted correlations between the phylogeny of parabasalians and that of their hosts.
Anxiety among Japanese nursing researchers before and after dispatch for COVID‐19 pandemic support: Effects of anxiety‐enhancing and buffering factors
Authors: Imazu Yoko , Kondo Akiko , Ushikubo Mitsuko , Kanbara Sakiko , Kawahara Noriko , Kondo Mari 
Published: June 2024

AbstractAimWe investigated the levels of anxiety and the factors influencing it among Japanese nursing researchers before and after engaging in dispatch support activities during the COVID‐19 pandemic. This study also tested the relationships between pre‐ and post‐relief anxiety and their enhancing and buffering factors.MethodsA web‐based survey was conducted with 9832 members from the Japan Academy of Nursing Science, covering 15 items related to participant attributes such as age and disaster relief qualifications, factors affecting anxiety about support activities such as the content and duration of one activity, and the level of anxiety before and after activities. After performing multiple regression analyses on the effects of the attributes and the factors influencing anxiety before and after support activities, path analysis was conducted on the adopted independent variables to examine their influence on anxiety before and after support activities.ResultsOf the 886 participants, 82.3% were affiliated with educational institutions and 94.8% had no qualifications in disaster relief. Most of the support involved vaccination and activities at health centers. The relationship between pre‐ and post‐relief activities and factors influencing anxiety constituted a high goodness‐of‐fit, with health center assistance being both a direct and indirect reinforcer of post‐relief anxiety.ConclusionsParticipants expressed anxiety enhanced by activities at the health center both before and after support activities in the wake of the COVID‐19 pandemic. Intervention research should examine anxiety‐buffering and ‐enhancing factors, and a support system to respond to rapidly increasing medical needs is necessary.
“Perinatal loss, a devastating cyclone”: A situation‐specific nursing theory
Authors: Furtado‐Eraso Sara , Marín‐Fernández Blanca , Escalada‐Hernández Paula 
Published: June 2024

AbstractPurposeThe aim of this paper is to develop a preliminary theory that explores in depth into understanding the experiences of women who have suffered a spontaneous perinatal loss during any trimester of their pregnancy regarding their emotional response to this loss.DesignA grounded theory approach was used, and 25 in‐depth interviews were conducted with Spanish women who suffered a spontaneous perinatal loss.MethodsTheoretical sampling and constant comparative analysis were used to reach theoretical saturation. EQUATOR guidelines were followed, using the COREQ checklist.ResultsThe “Perinatal loss, a devastating cyclone,” a situation‐specific nursing theory, explains the process that a woman experiences when she loses her baby at any stage of pregnancy, drawing an analogy with tropical cyclones as natural disasters that destroy everything in their path. This situation‐specific theory includes three dimensions, explaining the phases identified in the perinatal loss process (phase prior to impact [before the perinatal loss], impact phase [diagnostic moment], emergency phase [hospital care], relief or honeymoon phase [return home], disillusionment or stock‐taking phase [after the first postloss days at home], reconstruction and recovery phase [grief construction process] and consequences [with an eye to the future]). Three intervention areas were described around the perinatal loss process: “rescue area” (partner, grandparents, and siblings of the deceased baby), “relief area” (healthcare professionals), and “base camp” (society).ConclusionThe situation‐specific nursing theory “Perinatal loss, a devastating cyclone” is the final product of a grounded theory study that provided an in‐depth analysis of women's experiences when they suffer a spontaneous perinatal loss at any point in their pregnancy.Clinical RelevanceThe situation‐specific theory “Perinatal loss, a devastating cyclone” with the seven identified phases and the three areas of intervention could be used as a framework for healthcare professionals in their clinical practice as a guide to support women in this disfranchised grief.
Defining distress tolerance in a structural model of Big Five personality domains
Authors: Lopez Maria Martin , Naragon‐Gainey Kristin , Conway Christopher C. 
Published: June 2024

AbstractObjectiveDistress tolerance (DT)—willingness to face internal discomforts—has a fuzzy boundary with neuroticism (low emotional stability), raising questions about its independent role in models of personality and mental health.MethodWe investigated DT's overlap with neuroticism and other Big Five factors in a structural model of personality and personality disorder features in samples of university students (N = 1025), emotional disorder patients (N = 225), and substance‐use patients (N = 210).ResultsIn exploratory factor analyses, we found that DT indicators clustered with neuroticism and were essentially unrelated to other Big Five domains. Big Five personality dimensions collectively explained approximately 40%–70% of variation in DT, across different samples and methods of quantifying shared variance.ConclusionsWe conclude that DT and neuroticism are near neighbors in empirical space and speculate that much of the observed correlation between DT and mental health outcomes in the literature may be carried by shared neuroticism variance. We suggest that clearer distinctions between the two constructs in empirical research could improve our understanding of DT's unique role in the development and treatment of psychopathology.
Short‐term impact of a combination intervention on family cohesion: Results from a pilot cluster‐randomized clinical trial in Northern Ghana
Authors: Sensoy Bahar Ozge , Byansi William , Ibrahim Abdallah , Boateng Alice , Nartey Portia Buernarkie , Nabunya Proscovia , Kumbelim Kingsley , Ssewamala Fred M. , McKay Mary M. 
Published: June 2024

AbstractChild labor remains a concern in sub‐Saharan Africa. Yet, evidence‐based preventive efforts are limited. We analyzed longitudinal data from Ghanaian adolescent girls in a pilot randomized clinical trial testing the preliminary impact of a combination intervention on family cohesion as a protective factor against child labor and school dropout. While there was no statistical difference between the control and intervention groups at 9 months, the results show that family cohesion scores improved significantly from baseline to 9 months for the ANZANSI intervention group. Qualitative results indicated improved family cohesion in the intervention group. Hence, future studies should further examine this promising social work intervention.
Using technology broadcasting to explore market applications: The moderating role of a firm's domain‐specific and general knowledge
Authors: Rijssegem Laurence , Andries Petra 
Published: June 2024

AbstractInnovative firms, like startups, are increasingly making use of technology broadcasting to explore market applications for their technology. While findings from previous studies suggest that these firms can get access to a large pool of suggestions for market applications through technology broadcasting, we lack empirical evidence on whether firms that use technology broadcasting will actually be able to process and explore these suggestions. The current study points to the distinct role of firms' domain‐specific and general knowledge base in this respect. It proposes that technology broadcasting is positively related to the number of market applications a firm explores. Moreover, it hypothesizes that this relationship is weakened by the firm's domain‐specific knowledge and strengthened by its general knowledge base. We use Poisson analyses on hand‐collected survey and secondary data on a sample of 205 Flemish startups. We find that technology broadcasting is positively associated with the number of market applications a firm explores. Furthermore, this positive relationship is stronger with increasing general knowledge, but weaker with increasing domain‐specific knowledge. These findings advance our understanding of the boundary conditions of technology broadcasting. Additionally, our study contributes to the open innovation literature which has called for more attention to the challenges an organization faces in managing its external knowledge search. Finally, our study provides important practical insights for innovative firms that are trying to find market applications for their technology.
Cottonseed meal protein hydrolysate influences growth performance, carcass characteristics, serum biochemical indices, and intestinal morphology in yellow‐feather broilers
Authors: Zhang Xiaoyang , Nan Shanshan , Zhang Li , Chen Cheng , Zhang Wenju , Nie Cunxi 
Published: June 2024

AbstractThis study investigated the effects of cottonseed meal protein hydrolysate (CPH) on the growth performance, carcass characteristics, serum biochemical indices, intestinal morphology, and enzyme activities of yellow‐feather broilers. We randomly divided 240 chicks into four groups, each with six replicates: a basal diet with 0% (CON), 1% (LCPH), 3% (MCPH), or 5% (HCPH) CPH. The trail spanned 63 days and included three phases: Days 1–21, 22–42, and 43–63. Increased average daily gain (ADG) and decreased ratio of feed to gain (F/G) with LCPH were observed in 21‐day‐old broilers (P < 0.05). MCPH led to higher ADG and average daily feed intake (ADFI) in 42‐day‐old broilers (P < 0.05). Additionally, CPH supplementation resulted in increased dressing percentage, percentage of half‐eviscerated yield, percentage of eviscerated yield, breast muscle rate, and leg muscle rate were observed (P < 0.05) with diet. The serum levels of total protein (TP), high‐density lipoprotein cholesterol (HDL‐C), calcium (Ca), and phosphorus (P) were enhanced, and blood urea nitrogen (BUN) and triglyceride (TG) levels decreased with diet and CPH (P < 0.05). CPH increased the length of the jejunum and ileum and the weight of the duodenum, jejunum, and ileum in 21‐day‐old broilers (P < 0.05). Alterations in the duodenal villus structure in broilers occurred on Days 21 and 42, and the CPH groups performed better; however, a similar change occurred in the jejunum on Days 42 and 63 (P < 0.05). MCPH and HCPH enhanced trypsin activity in the duodenum of 21‐day‐old and 63‐day‐old broilers (p < 0.05). Chymotrypsin activity increased (P > 0.05) in the duodenum of 63‐day‐old broilers fed MCPH. Lipase activity increased (P < 0.05) in the jejuna of 21‐day‐old broilers treated with HCPH. CPH increased trypsin activity in the ilea of 21‐day‐old broilers (P < 0.05). These results showed that CPH influenced the growth performance, carcass characteristics, serum biochemical indices, and intestinal morphology of yellow‐feather broilers, which are related to growth stage. The recommended CPH level in broilers is 1% before 21 days of age and 3% after 21 days of age.