bluuebunny/crossref_metadata_2025_split huggingface dataset:
THE IMPACT OF INNOVATION ON THE PERFORMANCE OF SMALL AND MEDIUM-SIZED ENTERPRISES IN RUSSIA: ЕMPIRICAL ANALYSIS
Authors: Sererzhin P. D. 
Published: June 2024

The article is devoted to the study of the impact of different types of innovation on the efficiency of Russian SMEs. The purpose of the study is to assess the importance of different types of innovation for Russian SMEs and to determine the impact of types of innovation on the efficiency and competitiveness of SMEs. The research methodology involves a consistent approach combining qualitative and quantitative analysis. As a collection of information, a survey was conducted among owners of small and medium-sized enterprises in Russia on the use of innovations in the course of business activities in the last three years (2020–2023) and their impact on the company՚s performance. In addition, the experiences of some participants were explored through in-depth interviews. In total,112 entrepreneurs took part in the survey. The results of the study showed that innovations are used by the vast majority of small and medium-sized enterprises in Russia. There is no stable relationship between the size of enterprises and the innovations they choose, although in some cases we can say that certain companies tend to a certain type of innovation depending on the number of employees. Organisational innovations are the least popular in enterprises innovation, and the greatest marketing; marketing innovations showed the highest percentage of negative experiences during implementation, despite the fact that they are the most popular category of innovations.The majority of respondents see an improvement in the financial situation of the company according to various criteria and are satisfied with the results of innovation; at the same time, the larger the company, the more goals it pursues trough innovations. The smaller the business, the more interested it is in solving specific problems to increase sales, profits and customer loyalty. The larger the company, the more it follows the 360 strategy: that is, it pays attention to the creation of new goods and services, as well as to the introduction of innovations in production processes.
Profile and outcome of treatment in non-small cell lung cancer with brain metastasis
Authors: Rehman Uzma , Khan Nazir Ahmed , Nasreen Shahida , Gadda Irfan Rasool 
Published: June 2024

Background: Brain metastasis is a common problem in patients with NSCLC. This study was done to study the risk factors associated with the development of brain metastasis and assess treatment response in NSCLC to improve patient survival.
Methods: This was a retro-prospective study in which 126 patients with non-small cell lung carcinoma with brain metastasis were taken for the study.
Results: The mean age in study group was 56.1±12.72 years. Adenocarcinoma was found in 57.1% and squamous cell carcinoma in 41.3% patients. 65.9% patients received chemotherapy for primary disease followed by targeted therapy in 34 (27.0%) patients. 53.9% patients received WBRT after diagnosis of brain metastasis and 23% WBRT and systemic chemotherapy while as14.3% received WBRT and targeted therapy and 2.4% received WBRT, systemic chemotherapy and targeted therapy, 1.6% patients received systemic chemotherapy, WBRT and local RT to the primary site and 0.8% each was treated with gamma knife therapy; surgery, WBRT and targeted therapy; SRS and WBRT. Median overall survival of patients with brain metastasis who received WBRT was 2.5 months and patients who received WBRT and systemic chemotherapy was 9.0 months while patients with brain metastasis who received WBRT and targeted therapy was 14.3 months.
Conclusions: The median overall survival as per treatment received after diagnosis of brain metastasis was higher in patients who received WBRT and targeted therapy as compared to patients who received WBRT and systemic chemotherapy and patients who received WBRT only.
Genital dermatoses in children in a tertiary care hospital in Northeast India
Authors: Mistry Farhin , Gupta Bhaskar , Das Debajit 
Published: June 2024

: Skin conditions in children are impacted by their socio-economic status, environmental conditions, cultural and food habbits: To evaluate the frequency and pattern of non venereal genital dermatoses in children visiting the dermatology outpatient department at Silchar Medical College and Hospital, Silchar, a prospective research was carried out from December 2022 to December 2023: 127 children aged 1 to 18 years who had non venereal genital dermatoses verified by relevant bedside and laboratory examinations were included in the current study after providing appropriate informed permission. They were divided into four age groups: young children (ages 1-3), preschoolers (ages 3-6), students (ages 6-10), and teenagers (ages 9-18). : Of the 127 children—82 boys and 45 girls—37.77% attended school. Of the 110 children with infective dermatoses,75 percent lived in hostels; these individuals were primarily from rural areas and belonged to low (55.2%), middle (43.23%), and high (1.55%) socioeconomic groups. Bullous impetigo was the most prevalent infectious dermatosis in preschoolers, whereas genital scabies, tinea cruris, and molluscum contagiosum were the most frequent in teenagers. Of the 17 kids with non-infectious dermatoses, 55.2% come from a low-income background. 2.36% of patients had phrynoderma and nutritional deficiencies, whereas 0.79% had genital vitiligo. The additional non-infectious dermatoses that were discovered were eczema, hemangiomas, lichen planus, and lichen sclerosus. : school-going age group children are more likely to suffer from infectious dermatoses such as pyoderma, scabies, fungal infections than nutritional deficiencies. This is likely due to a combination of factors including poor health, poverty, poor personal hygiene, and a lack of access to soap and antifungals. Better nutrition and health education are recommended by our study.
A survey assessing the role of a fixed-dose combination of 0.3% adapalene with 2.5% benzoyl peroxide in acne vulgaris
Authors: Sen Dyotona , Walia Parmjit , Agarwal Megha , Jadhwar Sameer 
Published: June 2024

Acne is a common skin condition affecting adolescents and young adults, characterized by the blockage of sebaceous glands along with bacterial colonization of the follicular duct and inflammation. Collagen and tissue damage secondary to acne inflammation brings about severe skin texture changes, including scarring. Timely treatment initiation is crucial to prevent acne progression to scarring. Topical retinoids, topical oral antimicrobials, or a combination of both are recommended as the first-line therapy for acne. The objective of the present survey was to assess the role of 0.3% adapalene/2.5% benzoyl peroxide (BPO) combination in those with mild-moderate acne. The objective of the present survey was to assess the role of 0.3% adapalene/2.5% BPO combination in those with mild-moderate acne.: A total of 438 healthcare professionals (dermatologists and cosmetologists) participated in the survey, through which their patients’ experiences with the product were recorded. : A significant proportion of the patient population (31%) experienced improvement just after 2 weeks of treatment with the combination. Most patients (84%) also found it easy to include the product in their skincare regime. Most healthcare professionals and patients (&#62;80%) rated the effectiveness and tolerability of the intervention as ‘good’ to ‘excellent’. : The survey confirms the 0.3% adapalene/2.5% BPO combination as an efficacious, easy-to-use topical treatment option for moderate to severe acne with the potential to impact acne scars, in line with findings from other studies examining the effect of this combination.
Unraveling the tapestry of adverse cutaneous drug reactions: A clinico-epidemiological study
Authors: N Abhinesh , Salam Arisha , GP Rekha , Challa Tejaswi 
Published: June 2024

It is widely acknowledged that adverse drug responses on the skin can cause serious complications. Up to 2% of all adverse cutaneous medication eruptions are severe and life-threatening, however the majority of these reactions are benign. In order to quickly diagnose these grave cutaneous eruptions and start the necessary treatment, physicians should be aware of certain warning signs. To understand the causative drug, meticulous history and complete clinical examination is the key Primary objective is to find the common group of drugs causing adverse cutaneous drug reactions. Secondary objectives are to study their morphology, gender and age distribution. The cross-sectional study involved 130 patients. Informations including relevant history, clinical examination details, and drugs taken were noted in the pretested proforma. Quantitative and qualitative data were collected and graphically analysed. Data was studied under various aspects which included causative drugs, clinical presentation, age and gender ratio. SPSS Version 21.0 was used for most analysis and Microsoft Excel 2010 for graphical representation. Maculopapular rash, acneiform eruptions, urticarial rash, exfoliative dermatitis and fixed drug eruptions were the commonest forms of clinical presentations seen in our study. The cutaneous drug reactions were classified as per the study of Agarwal et al.The limitations of treating adverse cutaneous drug reactions are the varied range of clinical symptoms, the complexity of the various drug-host interactions, and the relative scarcity of laboratory tests that are available for any conclusive and confirmatory drug-specific testing. That's why knowledge of clinical presentations and common drugs causing it is a must.
Understanding women’s representation and participation in local government planning
Authors: Kgobe Frans , Ramoroka Tlou 
Published: June 2024

The extent of women's representation and visibility in local government planning in South Africa has been significantly constrained. Over the years, the recurring phenomenon of insufficient participation and representation in local governance has become a prevalent issue within the country. The inclusion and participation of women in the decision-making process of local government should not be driven solely by the necessity to comply with legislative and policy frameworks and not by just a mere representation in terms of reflecting on the number of participants. Incorporating diverse individuals and groups is crucial in guaranteeing that progress within communities is accomplished acceptably. The act of prioritizing men's interests or political opportunism over women's interests in local government planning lacks justification. This study elucidates diverse factors that underlie the insufficient involvement and representation of women in local government planning. These variables encompass the prevalence of custom, culture, and tradition; socialisation, attitudes, and stereotypes; violence against women in politics; the media; finances and resources; structural deficiencies; patriarchy; and education. The research relied on existing scholarly works and documented accounts to investigate the causative elements and explicate their effect on the developmental condition. The article posits that addressing these factors requires a comprehensive approach that includes a multifaceted approach and a dosage of sustained efforts to ensure that there is gender balance and fair representation of women in local government planning. The study contributes to a better understanding of the participation and representation of women in the context of local government planning. It provides insights into strategies for creating more inclusive opportunities for women to express their views and exercise influence in local decision-making procedures.
Unveiling the heartbeat of employee engagement and social responsibility: the mediating role of affective commitment in Ghanaian Universities
Authors: Prempeh Emmanuel Barima Agyemang , Dzansi Dennis Yao 
Published: June 2024

In the current higher education environment in Ghana, universities have directed their attention towards fulfilling their social obligations, which are referred to as University Social Responsibility (USR), to both their internal and external stakeholders. This study, driven by the Stakeholders Theory, examines the premise that affective commitment serves as a positive and substantial mediator in the relationship between USR and employee engagement. Therefore, this study investigates the impact of both internal and external corporate social responsibility (CSR) initiatives on the emotional commitment and level of involvement of employees in Ghanaian institutions. This study utilised the research onion framework to guide its methodology. It employed a cross-sectional survey design, based on the positivism paradigm and supported by the hypothetico-deductive model. The purpose was to test hypotheses and measure the relationships between user satisfaction and staff engagement, with affective commitment acting as a mediator. The study was conducted within the context of Ghanaian universities. A two-stage stratified sampling method was utilised to choose 412 participants for the survey. The data collected via a 5-point Likert scale empirically validated questionnaire with Cronbach’s alpha coefficient (?) > 0.70 was adapted for the survey. The data collected were configured and subjected to Structural Equation Modelling for analysis at a significance level of p<.05 using the SMART pls software. This survey found that affective commitment is a statistically significant factor that directly explains and predicts the mediation effect of internal CSR on employee engagement (beta=0.217; t>1.96; p=0.000: p<0.05), and external CSR on employee engagement (beta=0.065; t>1.96; p=0.000: p<0.05) in Ghanaian universities enrolled in the survey. This study recommends that public and private universities in Ghana should foster a strong sense of commitment and loyalty among employees towards the organisation and its CSR efforts.
Development and validation of anthropometric equations for the prediction of skeletal muscle mass in hospitalized adults and older people using computer tomography.
Authors: SOARES BRUNA , Soares NatalY , Burgos Maria Goretti , de Arruda Ilma 
Published: June 2024

Abstract

Objective: To develop and validate a prediction model for estimating skeletal muscle mass (SMM) in hospitalized adults and older people based on easily obtained demographic and anthropometric data and using computer tomography (CT) as the gold standard.
Methods: A methodological study was conducted with male and female participants ³ 20 years of age hospitalized at a public tertiary hospital in Northeast Brazil. Patients with characteristics that could influence the body composition analysis by CT and/or anthropometric measures were excluded. Sociodemographic characteristics and clinical data were obtained from the electronic records of the patients. Nutritional status was assessed using the anthropometric method (weight, height, body mass index, weight loss, arm circumference and calf circumference) and a subjective assessment. Abdominal CT images were used to obtain the area of SMM determined in cm2, taking density values of -29 to 150 Hounsfield units. Statistical analysis was performed with the aid of IBM SPSS version 16.0.
Results: The sample comprised 564 individuals 20 to 89 years of age. Two prediction models were created – one for adults (SMM = 66.28 + (-36.20*sex) + (3.04*CC) + (0.19*weight), R2 = 73.9%) and one for older people (SMM = -56.34 + (-26.70*sex) + (1.71*CC) + (0.97*height), R2 = 67.3%). The predictive capacity of these equations was 74.1% for adults and 67.7% for older people compared to SMM determined by CT (p < 0.001).
Conclusions: The equations developed in the present study should be tested for clinical purposes and in the analysis of data from mixed hospitalized populations.
Causal effects of AP on ovarian cancer risk in European and East Asian populations: a Mendelian randomization study
Authors: Tong Yan , lai zhiqing , liu zhaoxia 
Published: June 2024

Abstract

Background
Ovarian cancer (OC) is a great public health issue, and the relationship between OC and air pollution (AP) continues to be uncertain. Consequently, we implemented a TSMR analysis to assess the correlation between AP and the risk of OC.
Methods
From the UKB, we selected five risk factors related to AP (PM2.5, PM2.5-10, PM10, NO2, and NOx). The SNPs of OC from individuals of European and East Asian descent via the OCAC. Our main analytical technique was the IVW method, utilizing for calculating OR and 95% Cl. We implemented the weighted median, MR-Egger, simple, and weighted models for quality control, using Cochran's Q test for heterogeneity and MR-Egger regression and the MR-PRESSO test for pleiotropy detection. A leave-one-out strategy and the scatter plots were conducted to do sensitivity analyses. BMI, alcohol, and smoking were considered as potential mediators/confounders in MVMRs.
Results
Through TSMR analysis, we discovered a causal link between genetically inferred NOx commencement and OC risk in the European population (OR: 2.64, 95%CI: 1.152–6.087, P = 0.021). Some SNPs associated with the initiation of NOx production are linked toendometrioid OC(EnOC)risk (OR: 7.39, 95%CI: 1.209–45.171, P = 0.03). No statistical association was found between AP and OC levels in European (PM2.5: p = 0.993; PM2.5-10: p = 0.833; PM10: p = 0.257; NO2: p = 0.215; NOx: p = 0.614) or East Asian populations (PM2.5: p = 0.468; PM2.5-10: p = 0.814; PM10:p = 0.652; NO2: p = 0.392; NOx: p = 0.910). Even after adjusting for smoking and drinking through MVMR, a direct positive link between nitrogen oxide and OC risk was observed, which did not persist when BMI was accounted for (OR [95%CI] = 1.29 [0.76–2.19], p = 0.351), suggesting BMI may mediate the effect of nitrogen oxide on OC risk.
Conclusion
The results demonstrate a cause-and-effect relationship between exposure to NOx and OC risk, specifically for EnOC, within the European population.
Bone Alterations around Dental Implants Placed with Flapless Guided Surgery Technique with or without immediate loading: A Retrospective 1-Year Follow-Up
Authors: Marão Heloisa Fonseca , Campos Annika Ingrid Maria Soderberg , Santos Pâmela Leticia dos , de Oliveira Guilherme José Pimentel Lopes , Gulinelli Jéssica Lemos 
Published: June 2024

Abstract

Purpose: The aim of this study was to assess, after 1-year follow-up, the marginal bone alterations around dental implants placed by using the flapless guided surgery technique with and without immediate loading.
Methods: For this, conventional loading was placed in 8 patients (G1), whereas immediate loading was placed in the other 8 patients (G2). Tomographic measurements of the buccal and palatal bone wall thickness and buccal, palatal, mesial, distal bone wall height were measured in the cone beam computed tomography after the surgery (T0) and 1 year after the prosthesis installation (T1).
Results: The results showed of the 16 patients treated, ten were female and six were men. There were statistically significant differences between T0 and T1 in both groups regarding buccal bone resorption (buccal-G1-P=0.0185;G2-P=0.0017), palatal bone resorption (palatal-G1-P=0.008) and loss of vertical bone height in the buccal (G1 P=0.0066;G2-P=0,0015), palatal (G1-P=0,0015;G2-P<0.001), mesial (G1-P=0.0029; G2-P=0.001), and distal (G1-P<0.002;G2-P<0.005) walls. Regarding the comparison between G1 and G2, there were no statistically significant differences for all parameters evaluated at time T0 and T1.
Conclusions: This study indicates that the flapless guided surgery technique with or without immediate loading did not influence in the marginal bone loss around dental implants after 1-year follow-up.
Gastrointestinal Calciphylaxis: A Rare and Devastating Complication in End-Stage Renal Disease
Authors: Aarabi Amirhossein , Kumar Karthik 
Published: June 2024

Abstract

Calciphylaxis, also known as calcific uremic arteriolopathy (CUA), is an exceptionally rare and severe condition that predominantly affects individuals with end-stage renal disease (ESRD). It manifests through vascular calcifications that precipitate tissue necrosis, with cutaneous manifestations being common. However, gastrointestinal (GI) involvement is an infrequent but gravely serious occurrence.
In this report, we present an atypical case of GI calciphylaxis in a 66-year-old woman undergoing peritoneal dialysis. The patient's initial symptoms of abdominal pain and turbid peritoneal fluid raised suspicions of bacterial peritonitis. Despite therapeutic interventions, the patient's condition deteriorated. Computed tomography (CT) imaging revealed a perforation in the caecal wall, necessitating emergent surgical intervention. Histopathology post-surgery confirmed the diagnosis of GI calciphylaxis.
The patient's postoperative trajectory was fraught with complications, ultimately leading to a fatal outcome. This case underscores the critical need for increased vigilance for calciphylaxis in the differential diagnosis when abdominal pain develops in patients with ESRD, regardless of the presence of characteristic dermatological symptoms. Prompt detection and an integrated care approach are essential for improved prognosis. Further research is needed to find more efficacious treatments for this devastating illness.
Characterization and Innovative Process of Oily Wastewater from Substations
Authors: HUANG Yan , Wen Shangyong , WAN Zhengdong , Xin Hongyan , Li Kaiman 
Published: June 2024

Abstract

The increasing demand for electrical power has led to a surge in the construction of substations worldwide. In the context of today's carbon emission reduction, more and more people are be-ginning to pay attention to the treatment of oily wastewater generated from substations. The specific traits such as the complicated components and rapid change in the raw wastewater quality make it rather hard to be degraded thoroughly and economically. In response to this challenge, we introduce a novel solution that combines pre-treatment, dissolved air flotation, and fine multi-stage filtration techniques to efficiently remove oil and suspended solids from oily wastewater discharge. This study comprehensively summarizes the characteristics of oil-containing wastewater in substations and invents a novel process for treating oil-containing wastewater from substations. It exhibits notable advantages in terms of energy efficiency and cost-effectiveness compared to conventional treatment methods. This research not only promotes the technical advances in the field of wastewater treatment but also provides a practical and sustainable solution for industries grappling with the conundrum of oily wastewater manage-ment. The findings presented here can be supposed to serve as a stepping stone towards the development of more efficient and environmentally friendly wastewater treatment strategies.