bluuebunny/crossref_metadata_2025_split huggingface dataset:
Exploring the Relationship between Food Insecurity, Chronic Health Conditions, and Serious Mental Illness in the United States: Implications for Social Work
Authors: Berrett-Abebe Julie , Reed Sarah C 
Published: May 2024

Abstract
Food insecurity (FI) is a modifiable social determinant of health that impacts approximately 10 percent of the U.S. population. FI has been linked to poorer health outcomes and higher healthcare costs. Given the prevalence of chronic health conditions in the United States, including serious mental illness (SMI), the current study aims to better understand the relationship between FI and chronic conditions, including SMI, in a nationally representative sample. Authors analyzed data from the 2016 Medical Expenditure Panel Survey household component and food security supplement. Findings indicate the prevalence of FI among those with diabetes, lung disease, stroke, and SMI is higher than among the general population, with the prevalence for those with SMI being particularly high (43 percent of the sample). Logistic regression models indicate strong, statistically significant relationships between FI and chronic conditions, including SMI, as well as FI and two or more chronic illnesses, even when controlling for sociodemographic and health factors. There are likely bidirectional relationships between FI and chronic conditions. Findings have implications for social workers, in relation to prevention and treatment of SMI and FI through direct care, advocacy, and integrated services in health, mental health, and social services.
Adverse Childhood Experiences and Their Relationships with Perceived Stress and Self-Care Behaviors in African American Social Work Students: Insights from a Latent Class Analysis
Authors: Lee Jaegoo , Allen Trenia L , Hernandez Pedro M , Tompkins Sherita , Richards Kristin V 
Published: May 2024

Abstract
Based on stress sensitization theory and stress proliferation theory, this study was designed to identify adverse childhood experience (ACE) classes and their relationships with perceived stress and self-care behaviors. Hypotheses were that (a) there would be diverse ACE classes among African American social work students; (b) the identified classes embedded in high/multiple ACEs would have greater levels of perceived stress than those in low ACEs; and (c) the identified classes embedded in high/multiple ACEs would have lower levels of self-care behaviors than those in low ACEs. Recruited from one of the South’s historically Black colleges and universities, 186 African American social work students completed an online survey. Latent class analysis found three classes fit the data best: low ACEs, high divorce/abuse/neglect, and high/multiple ACEs. Students in the high divorce/abuse/neglect class had the greatest levels of perceived stress and significantly greater perceived stress levels than the low ACEs class. The low ACEs class had greater self-care behaviors than students in the other two ACEs classes. The study revealed diverse ACE classes and the effect of more ACEs on greater perceived stress and lower self-care behaviors, supporting the importance of using a range of approaches to support African American social work students with different ACEs.
Thoracoscopic segmentectomy for trans-fissure ground-glass opacity
Authors: Zhang Min , Wu Anming , Zhang Cheng , Ge Mingjian , Sihoe Alan D L 
Published: May 2024

Abstract

OBJECTIVES
The trans-fissure ground-glass opacity (GGO) is a special category of lesions, with a diameter always exceeding 2 cm. It is located on a fused fissure, ‘seizing’ 2 neighbouring lobes simultaneously. The segmentectomy for the trans-fissure GGO is never reported.

METHODS
Between August 2016 and December 2022, patients operated with a trans-fissure GGO were included. The patients’ backgrounds and surgical data were summarized. All procedures were performed with the help of preoperative three-dimensional computed tomography bronchography and angiography.

RESULTS
A total of 84 patients were included. The selection criteria included a consolidation tumour ratio &lt;50% and a lesion size &gt;2 and ≤3 cm. Thirty-six patients were operated with lobectomy + wedge (the traditional method group) and 48 patients were operated with anatomical segmentectomy + function-preserving sublobectomy (the new method group). The median operative time was 87 min in the traditional group and 98 min in the new method group, and the median blood loss was 60 ml in the traditional group and 70 ml in the new method group. The median duration of hospital stays was 4 days in the traditional group and 2 days in the new method group. In the traditional method group, there was 1 case of postoperative air leakage and 5 cases of haemoptysis. In the new method group, 2 cases of postoperative air leakage were identified. The median size of the tumour in the resected segment was 2.6 cm in the traditional group and 2.5 cm in the new method group. The median margin was 2.5 cm in the traditional group and 3.3 cm in the new method group.

CONCLUSIONS
The trans-fissure GGO could be safely resected en bloc by segmentectomy with a well-designed surgical procedure and appropriate preoperative planning.
Identification of potential mediators of the relationship between body mass index and colorectal cancer: a Mendelian randomization analysis
Authors: Bouras Emmanouil , Gill Dipender , Zuber Verena , Murphy Neil , Dimou Niki , Aleksandrova Krasimira , Lewis Sarah J , Martin Richard M , Yarmolinsky James , Albanes Demetrius , Brenner Hermann , Castellví-Bel Sergi , Chan Andrew T , Cheng Iona , Gruber Stephen , Van Guelpen Bethany , Li Christopher I , Le Marchand Loic , Newcomb Polly A , Ogino Shuji , Pellatt Andrew , Schmit Stephanie L , Wolk Alicja , Wu Anna H , Peters Ulrike , Gunter Marc J , Tsilidis Konstantinos K 
Published: May 2024

Abstract

Background
Colorectal cancer (CRC) is the third-most-common cancer worldwide and its rates are increasing. Elevated body mass index (BMI) is an established risk factor for CRC, although the molecular mechanisms behind this association remain unclear. Using the Mendelian randomization (MR) framework, we aimed to investigate the mediating effects of putative biomarkers and other CRC risk factors in the association between BMI and CRC.

Methods
We selected as mediators biomarkers of established cancer-related mechanisms and other CRC risk factors for which a plausible association with obesity exists, such as inflammatory biomarkers, glucose homeostasis traits, lipids, adipokines, insulin-like growth factor 1 (IGF1), sex hormones, 25-hydroxy-vitamin D, smoking, physical activity (PA) and alcohol consumption. We used inverse-variance weighted MR in the main univariable analyses and performed sensitivity analyses (weighted-median, MR–Egger, Contamination Mixture). We used multivariable MR for the mediation analyses.

Results
Genetically predicted BMI was positively associated with CRC risk [odds ratio per SD (5 kg/m2) = 1.17, 95% CI: 1.08–1.24, P-value = 1.4 × 10−5] and robustly associated with nearly all potential mediators. Genetically predicted IGF1, fasting insulin, low-density lipoprotein cholesterol, smoking, PA and alcohol were associated with CRC risk. Evidence for attenuation was found for IGF1 [explained 7% (95% CI: 2–13%) of the association], smoking (31%, 4–57%) and PA (7%, 2–11%). There was little evidence for pleiotropy, although smoking was bidirectionally associated with BMI and instruments were weak for PA.

Conclusions
The effect of BMI on CRC risk is possibly partly mediated through plasma IGF1, whereas the attenuation of the BMI–CRC association by smoking and PA may reflect confounding and shared underlying mechanisms rather than mediation.
Construction of a grpE-based plasmid addiction system in Escherichia coli and its application in phloroglucinol biosynthesis
Authors: Wang Ji-ming , Cao Yu-jin , Men Xiao , Zhang Hai-bo 
Published: May 2024

Abstract

Aim
Biotechnical processes in Escherichia coli often operate with artificial plasmids. However, these bioprocesses frequently encounter plasmid loss. To ensure stable expression of heterologous genes in E. coli BL21(DE3), a novel plasmid addiction system (PAS) was developed.

Methods and results
This PAS employed an essential gene grpE encoding a cochaperone in the DnaK-DnaJ-GrpE chaperone system as the selection marker, which represented a chromosomal ΔgrpE mutant harboring episomal expression plasmids that carry supplementary grpE alleles to restore the deficiency. To demonstrate the feasibility of this system, it was implemented in phloroglucinol (PG) biosynthesis, manifesting improved host tolerance to PG and increased PG production. Specifically, PG titer significantly improved from 0.78 ± 0.02 to 1.34 ± 0.04 g l−1, representing a 71.8% increase in shake-flask fermentation. In fed-batch fermentation, the titer increased from 3.71 ± 0.11 to 4.54 ± 0.10 g l−1, showing a 22.4% increase. RNA sequencing and transcriptome analysis revealed that the improvements were attributed to grpE overexpression and upregulation of various protective chaperones and the biotin acetyl-CoA carboxylase ligase coding gene birA.

Conclusion
This novel PAS could be regarded as a typical example of nonanabolite- and nonmetabolite-related PAS. It effectively promoted plasmid maintenance in the host, improved tolerance to PG, and increased the titer of this compound.
Secular trends in the incidence and treatment patterns of primary hyperparathyroidism in Korea: a nationwide cohort study
Authors: Kim Kyoung Jin , Baek Seungjin , Yu Min Heui , Shin Sungjae , Cho Sungjoon , Rhee Yumie , Hong Namki 
Published: May 2024

Abstract
Data on epidemiology and secular trend in primary hyperparathyroidism (PHPT) in adults are relatively limited in Asian countries. This study aims to provide an overview of the secular trends in incidence, clinical characteristics, and treatment patterns of PHPT in South Korea. We used Korea’s National Health Insurance Claim database (2005-2020) to identify newly diagnosed PHPT cases. Individuals with age below 19, fewer than 2 E21.0 diagnoses, fewer than 2 PTH measurements, secondary hyperparathyroidism, undergoing dialysis or kidney transplantation within a year of diagnosis, parathyroidectomy (PTX) within a year prior to the diagnosis code, and diagnosis of multiple endocrine neoplasm or parathyroid carcinoma were excluded from the analysis. A total of 6837 patients with PHPT (PTX, n = 2989; non-surgery, n = 3848) were compared with 1:10 age- and sex-matched controls (n = 68 370). The mean age of patients with PHPT was 56.0 years, with 77.4% being women. The annual incidence of PHPT increased from 0.23/100 000 persons in 2005 to 1.75 in 2020, with higher rate in women than in men. Compared with 2005-2010 (n = 675), the number of newly diagnosed PHPT cases increased up to 3.1-fold (n = 2119) in 2011-2015 and 6.0-fold (n = 4043) in 2016-2020 periods. Among all patients with PHPT, 43.7% of patients underwent PTX, with decrement of proportion of bilateral surgery among PTX group across time (11.9% in 2005-2010 to 8.9% in 2016-2020, P for trend .033). Among all patients with PHPT, non-surgery group increased from 41.6% in 2005-2010 to 58.0% in 2016-2020 (P for trend &lt;.001). Patients with PHPT had higher odds of osteoporosis (odds ratio [OR] 7.03), renal stones (OR 10.55), chronic kidney diseases (OR 7.42), and cardiovascular, metabolic, and neurological conditions after adjustment for comorbidity index. In summary, the incidence of PHPT increased from 2005 to 2020 with predominance of non-surgical treatment, which calls for research focus on improving non-surgical management.
Do Not Risk Homicide: Abortion After 10 Weeks Gestation
Authors: Braddock Matthew 
Published: May 2024

Abstract
When an abortion is performed, someone dies. Are we killing a human person? Widespread disagreement exists. However, it is not necessary to establish personhood in order to establish the wrongness of abortion: a substantial chance of personhood is enough. We defend The Do Not Risk Homicide Argument: abortions are wrong after 10 weeks gestation because they substantially and unjustifiably risk homicide, the unjust killing of a human person. Why 10 weeks? Because the cumulative evidence establishes a substantial chance (a more than one in five chance) that preborn human beings are persons after 10 weeks (if not before then). We submit evidence from our bad track record, widespread disagreement about personhood (after 10 weeks gestation), problems with theories of personhood, the similarity between preborn human beings and premature newborns, miscalculations of gestational age, and the common intuitive responses of women to their pregnancies and miscarriages. Our argument is cogent because it bypasses the stalemate over preborn personhood and rests on common ground rather than contentious metaphysics. It also strongly suggests that society must do more to protect preborn human beings. We briefly discuss its practical implications for fetal pain relief, social policy, and abortion law.
Does Military Experience Really Matter? An Empirical Examination of Decision Framing and Deterrence Decision-Making
Authors: Berejikian Jeffrey D , Zwald Zachary 
Published: May 2024

Abstract
While it is widely understood that risk tolerance shapes conflict behavior, research in cognitive psychology has long demonstrated that reframing otherwise identical objective conditions can significantly alter people’s risk perception. Nonetheless, the potential impact of reframing during immediate deterrence has received little empirical scrutiny. In this study, we focus our attention on a comparison of the lay public and experienced military officials who, due to their expertise and training, are presumed to be less vulnerable to cognitive biases when making judgments about military affairs. To test this proposition, we deployed a unique set of deterrence decision experiments that, for the first time, directly compare the impact of reframing on a representative sample of the public and on a large (n = 479) sample of experienced active-duty US military officers (ranked Major through General) across three conflict domains (conventional, cyber, and nuclear). We find that, despite their greater expertise with military operations, officers are not less vulnerable to reframing than the lay public. Our results both conditionally challenge the common refrain that military officers serve as “adults in the room” during a crisis and establish that reframing within a crisis constitutes an underexplored mechanism that can both stabilize and destabilize deterrence dynamics.
Data triangulation strategies to design a representative household survey of hosts and Rohingya displaced in Cox’s Bazar, Bangladesh
Authors: Endara Joaquin , Genoni Maria Eugenia , Khan Afsana I , Kosmidou-Bradley Walker , Muñoz Juan , Palaniswamy Nethra , Vishwanath Tara 
Published: May 2024

Abstract
Obtaining representative information on hosts and displaced populations in a single survey is not straightforward. This article demonstrates the value of combining traditional and nontraditional sampling frames, geospatial information, and listing exercises to design a representative survey of hosts and Rohingya displaced populations in Cox’s Bazar, Bangladesh. The article applies innovative segmentation techniques using geospatial data to delimit enumeration areas in the absence of updated cartography. The article also highlights the importance of listing exercises to inform stratification decisions and update population counts.
Modelling the galaxy radio continuum from star formation and active galactic nuclei in the Shark semi-analytic model
Authors: Hansen Samuel P , Lagos Claudia D P , Bonato Matteo , Cook Robin H W , Davies Luke J M , Delvecchio Ivan , Tompkins Scott A 
Published: May 2024

ABSTRACT
We present a model of radio continuum emission associated with star formation (SF) and active galactic nuclei (AGNs) implemented in the Shark semi-analytic model of galaxy formation. SF emission includes free-free and synchrotron emission, which depend on the free-electron density and the rate of core-collapse supernovae with a minor contribution from supernova remnants, respectively. AGN emission is modelled based on the jet production rate, which depends on the black hole mass, accretion rate, and spin, and includes synchrotron self-absorption. Shark reproduces radio luminosity functions (RLFs) at $1.4\, \rm GHz$ and $150\, \rm MHz$ for 0 ≤ z ≤ 4, and scaling relations between radio luminosity, star formation rate, and infrared luminosity of galaxies in the local and distant universe in good agreement with observations. The model also reproduces observed number counts of radio sources from 150 MHz to 8.4 GHz to within a factor of 2 on average, though larger discrepancies are seen at the very bright fluxes at higher frequencies. We use this model to understand how the radio continuum emission from radio-quiet AGNs can affect the measured RLFs of galaxies. We find current methods to exclude AGNs from observational samples result in large fractions of radio-quiet AGNs contaminating the ‘star-forming galaxies’ selection and a brighter end to the resulting RLFs.We investigate how this affects the infrared-radio correlation (IRRC) and show that AGN contamination can lead to evolution of the IRRC with redshift. Without this contamination, our model predicts a redshift- and stellar mass-independent IRRC, except at the dwarf-galaxy regime.
Neurofascialvascular training for the treatment of Raynaud’s phenomenon: A case report
Authors: Bertacchini Paolo 
Published: May 2024

ABSTRACT
Primary Raynaud’s phenomenon (PRP) is characterised by episodic, reversible, and disabling vasospasms of the peripheral arteries. In the most severe cases, it can lead to ulceration of the fingers and toes. Neuro fascial VascularTraining (NFVT) is a novel therapeutic approach for treating PRP. NFVT aims to enhance peripheral circulation and stimulate the autonomic nervous system (ANS) by engaging multiple physiological mechanisms simultaneously. This integrated approach works to reduce vasospasms and alleviate associated symptoms through neurodynamic and myofascial interventions. A 54-year-old woman, who has experienced pain and hypoesthesia in her hands for 9 years, received a diagnosis of PRP without systemic sclerosis in 2014. The patient reported daily colour changes in her fingers, along with pain and a temporary decrease in tactile sensitivity. The patient engaged in ten 30-minute exercise sessions, and the clinical outcomes were assessed based on several parameters. These included the frequency and duration of vasospastic attacks, evaluated using the Raynaud Condition Score, as well as pain and tingling, measured through the daily Numeric Rating Scale. The Composite Autonomic Symptom Score (COMPASS 31) was utilised to assess dysautonomia, while the frequency of medication use and the Disabilities of the Arm, Shoulder, and Hand questionnaire were also considered. The results indicated a significant improvement in symptoms. NFVT improved symptoms and motor dysfunction in a patient with Raynaud’s syndrome, demonstrating how NFVT can increase peripheral blood flow, stimulate the ANS, and improve symptoms in PRP.
Massively parallel dissection of RNA in RNA–protein interactions in vivo
Authors: Lee Yu Hsuan , Hass Evan P , Campodonico Will , Lee Yong Kyu , Lasda Erika , Shah Jaynish S , Rinn John L , Hwang Taeyoung 
Published: May 2024

Abstract
Many of the biological functions performed by RNA are mediated by RNA-binding proteins (RBPs), and understanding the molecular basis of these interactions is fundamental to biology. Here, we present massively parallel RNA assay combined with immunoprecipitation (MPRNA-IP) for in vivo high-throughput dissection of RNA–protein interactions and describe statistical models for identifying RNA domains and parsing the structural contributions of RNA. By using custom pools of tens of thousands of RNA sequences containing systematically designed truncations and mutations, MPRNA-IP is able to identify RNA domains, sequences, and secondary structures necessary and sufficient for protein binding in a single experiment. We show that this approach is successful for multiple RNAs of interest, including the long noncoding RNA NORAD, bacteriophage MS2 RNA, and human telomerase RNA, and we use it to interrogate the hitherto unknown sequence or structural RNA-binding preferences of the DNA-looping factor CTCF. By integrating systematic mutation analysis with crosslinking immunoprecipitation, MPRNA-IP provides a novel high-throughput way to elucidate RNA-based mechanisms behind RNA–protein interactions in vivo.
AcrIIA28 is a metalloprotein that specifically inhibits targeted-DNA loading to SpyCas9 by binding to the REC3 domain
Authors: Kim Gi Eob , Park Hyun Ho 
Published: May 2024

Abstract
CRISPR–Cas systems serve as adaptive immune systems in bacteria and archaea, protecting against phages and other mobile genetic elements. However, phages and archaeal viruses have developed countermeasures, employing anti-CRISPR (Acr) proteins to counteract CRISPR–Cas systems. Despite the revolutionary impact of CRISPR–Cas systems on genome editing, concerns persist regarding potential off-target effects. Therefore, understanding the structural and molecular intricacies of diverse Acrs is crucial for elucidating the fundamental mechanisms governing CRISPR–Cas regulation. In this study, we present the structure of AcrIIA28 from Streptococcus phage Javan 128 and analyze its structural and functional features to comprehend the mechanisms involved in its inhibition of Cas9. Our current study reveals that AcrIIA28 is a metalloprotein that contains Zn2+ and abolishes the cleavage activity of Cas9 only from Streptococcus pyrogen (SpyCas9) by directly interacting with the REC3 domain of SpyCas9. Furthermore, we demonstrate that the AcrIIA28 interaction prevents the target DNA from being loaded onto Cas9. These findings indicate the molecular mechanisms underlying AcrIIA28-mediated Cas9 inhibition and provide valuable insights into the ongoing evolutionary battle between bacteria and phages.
Reduction of ZFX levels decreases histone H4 acetylation and increases Pol2 pausing at target promoters
Authors: Hsu Emily , Hutchison Katherine , Liu Yao , Nicolet Charles M , Schreiner Shannon , Zemke Nathan R , Farnham Peggy J 
Published: May 2024

Abstract
The ZFX transcriptional activator binds to CpG island promoters, with a major peak at ∼200–250 bp downstream from transcription start sites. Because ZFX binds within the transcribed region, we investigated whether it regulates transcriptional elongation. We used GRO-seq to show that loss or reduction of ZFX increased Pol2 pausing at ZFX-regulated promoters. To further investigate the mechanisms by which ZFX regulates transcription, we determined regions of the protein needed for transactivation and for recruitment to the chromatin. Interestingly, although ZFX has 13 grouped zinc fingers, deletion of the first 11 fingers produces a protein that can still bind to chromatin and activate transcription. We next used TurboID-MS to detect ZFX-interacting proteins, identifying ZNF593, as well as proteins that interact with the N-terminal transactivation domain (which included histone modifying proteins), and proteins that interact with ZFX when it is bound to the chromatin (which included TAFs and other histone modifying proteins). Our studies support a model in which ZFX enhances elongation at target promoters by recruiting H4 acetylation complexes and reducing pausing.