bluuebunny/crossref_metadata_2025_split huggingface dataset:
Voltammetric Determination of 2′‐Deoxyadenosine and Adenine in Urine of Patients with Hepatocellular Carcinoma Using Fullerene‐C60‐modified Glassy Carbon Electrode
Authors: Goyal Rajendra N. , Chatterjee Sanghamitra , Bishnoi Sunita 
Published: April 2009

AbstractA fullerene‐C60‐modified glassy carbon electrode has been examined for the simultaneous determination of 2′‐deoxyadenosine (2′‐dAdo) and adenine in human blood and urine using Osteryoung square‐wave voltammetry (OSWV) at pH 7.2. Compared to bare glassy carbon electrode (GCE), the modified electrode displays a shift of the oxidation potential in the negative direction with significant increase in the peak current for both the analytes. At modified electrode well‐defined anodic peaks at potential of 1248 mV and 994 mV are observed for 2′‐dAdo and adenine respectively. Linear calibration curves were obtained within the concentration range 10 nM to 100 μM for both the compounds in 0.1 M phosphate buffer solution (PBS) with the limit of detection 0.8×10−8 M and 0.95×10−8 M for 2′‐dAdo and adenine respectively. The analytical utility of the present method is demonstrated by quantitative detection of 2′‐dAdo and adenine in human urine of normal subjects as well as in patients with hepatocellular carcinoma. Interfering effect of some coexisting metabolites has also been reported.
Chloroperoxidase Modified Electrode for Amperometric Determination of 2,4,6‐Trichlorophenol
Authors: Díaz‐Díaz Goretti , Blanco‐López M. Carmen , Lobo‐Castañón M. Jesús , Miranda‐Ordieres Arturo J. , Tuñón‐Blanco Paulino 
Published: April 2009

AbstractA carbon paste‐poly(o‐phenylendiamine)‐modified electrode to be used as amperometric biosensor for 2,4,6‐trichlorophenol (TCP) is described. The enzyme chloroperoxidase (EC 1.11.1.10) from Caldariomyces fumago is immobilized through dispersion in a graphite paraffin oil carbon paste covered by an electrogenerated poly(o‐phenylendiamine) (PPD) layer. The main enzymatic dehalogenation product, 2,6‐dichloro‐1,4‐benzoquinone (DCQ) is characterized by liquid chromatography‐mass spectrometry and cyclic voltammetry. This product is electrochemically active and can be detected amperometrically at +150 mV vs. Ag|AgCl|KCl (3 M). The biosensor exhibits a response time of 4 min, a detection limit of 10−7 M, and a dynamic linear range between 10−7 and 10−6 M. Selectivity as well as operating and storage stability were evaluated.
An Aptamer‐Based Bound/Free Separation System for Protein Detection
Authors: Fukasawa Mieko , Yoshida Wataru , Yamazaki Hiroki , Sode Koji , Ikebukuro Kazunori 
Published: April 2009

AbstractAptamer hybridizes with its complementary strand. However, the complementary strand has difficulties to hybridize with the aptamer bound to a target because the aptamer forms higher‐order structures. Exploiting this property, we developed simple bound/free separation systems for thrombin and IgE detection. The complementary strand was immobilized onto beads and the aptamer was labeled with pyrroquinoline quinone glucose dehydrogenase (PQQGDH). In the absence of a target, the aptamer is trapped by beads, whereas in the presence of a target, the aptamer bound to the target is not trapped. Thus the aptamer‐target complexes can be recovered easily and detected by PQQGDH activity. This system allow the detection of 270 pM thrombin and 1 nM IgE.
Electroanalytical Determination of Cadmium(II) and Lead(II) Using an Antimony Nanoparticle Modified Boron‐Doped Diamond Electrode
Authors: Toghill Kathryn E. , Xiao Lei , Wildgoose Gregory G. , Compton Richard G. 
Published: April 2009

AbstractWe report the simultaneous electroanalytical determination of Pb2+ and Cd2+ by linear sweep anodic stripping voltammetry (LSASV) using an antimony nanoparticle modified boron doped diamond (Sb‐BDD) electrode. Sb deposition was performed in situ with the analytes, from a solution of 1 mg L−1 SbCl3 in 0.1 M HCl (pH 1). Pb2+ inhibited the detection of Cd2+ during simultaneous additions at the bare BDD electrode, whereas in the presence of antimony, both peaks were readily discernable and quantifiable over the linear range 50–500 μg L−1.
An efficient technique to estimate the realisation bit error rate of multiband OFDM based UWB systems
Authors: Masazade Engin , Keskinoz Mehmet 
Published: April 2009

AbstractIn this paper, we present a simple method to estimate the realisation bit error rate (RBER) of a multiband orthogonal frequency division multiplexing (OFDM)‐based ultra‐wide band (UWB) system. Under time‐varying channels, error event based BER estimation of convolutionally encoded systems requires the knowledge of error events in the Viterbi decoding. In this work, we show that the upper‐bound of instantaneous outage capacity is a function of the percentage of subcarriers, whose signal‐to‐noise (SNR) ratio is less than a predefined outage threshold which we call as realisation outage ratio (ROR). Simulation results reveal that the RBER of the channel realisations and their corresponding ROR are highly correlated at an optimally selected outage threshold. Using this correlation, we form a simple mathematical model between ROR and RBER and obtain quite accurate and consistent RBER estimates with respect to the error event based RBER estimates and the empirical RBER simulation results. Copyright © 2009 John Wiley & Sons, Ltd.
Selective processing of social stimuli in the superficial amygdala
Authors: Goossens Liesbet , Kukolja Juraj , Onur Oezguer A. , Fink Gereon R. , Maier Wolfgang , Griez Eric , Schruers Koen , Hurlemann Rene 
Published: April 2009

AbstractThe human amygdala plays a pivotal role in the processing of socially significant information. Anatomical studies show that the human amygdala is not a single homogeneous structure but is composed of segregable subregions. These have recently been functionally delineated by using a combination of functional magnetic resonance imaging (fMRI) and cytoarchitectonically defined probabilistic maps. However, the response characteristics and individual contribution of these subregions to the processing of social‐emotional stimuli are little understood. Here, we used this novel technique to segregate intra‐amygdalar responses to facial expressions and nonsocial control stimuli. We localized facial expression‐evoked signal changes bilaterally in the superficial amygdala, which suggests that this subregion selectively extracts the social value of incoming sensory information. Hum Brain Mapp, 2009. © 2009 Wiley‐Liss, Inc.
Attachment avoidance modulates neural response to masked facial emotion
Authors: Suslow Thomas , Kugel Harald , Rauch Astrid Veronika , Dannlowski Udo , Bauer Jochen , Konrad Carsten , Arolt Volker , Heindel Walter , Ohrmann Patricia 
Published: April 2009

AbstractAccording to recent models of individual differences in attachment organization, a basic dimension of adult attachment is avoidance. Attachment‐related avoidance corresponds to tendencies to withdraw from close relationships and to an unwillingness to rely on others. In the formation of attachment orientation during infancy facial emotional interaction plays a central role. There exists an inborn very rapid decoding capacity for facial emotional expression. In this study, functional magnetic resonance imaging was used to examine differences in automatic brain reactivity to facial emotions as a function of attachment avoidance in a sample of 51 healthy adults. Pictures of sad and happy faces (which are approach‐related interpersonal signals) were presented masked by neutral faces. The Relationship Scales Questionnaire (RSQ) was used to assess the attachment avoidance. Masked sad faces activated the amygdala, the insula, occipito‐temporal areas, and the somatosensory cortices. Independently from trait anxiety, depressivity, and detection performance, attachment avoidance was found to be inversely related to responses of the primary somatosensory cortex (BA 3) to masked sad faces. A low spontaneous responsivity of the primary somatosensory cortex to negative faces could be a correlate of the habitual unwillingness to deal with partners' distress and needs for proximity. The somatosensory cortices are known to be critically involved in the processes of emotional mimicry and simulation which have the potential to increase social affiliation. Our data are consistent with the idea that people who withdraw from close relationships respond spontaneously to a lesser extent to negative interpersonal emotional signals than securely attached individuals. Hum Brain Mapp, 2009. © 2009 Wiley‐Liss, Inc.
Alcohol hangover: a critical review of explanatory factors
Authors: Prat Gemma , Adan Ana , Sánchez‐Turet Miquel 
Published: April 2009

AbstractObjectiveTo describe the hangover phenomenon and briefly review its main explanatory factors.DesignBibliographic research on main databases (Medline and Psychinfo).ResultsAlcohol hangover is characterized by adverse physical and mental effects that occur the next morning after the intake of toxic doses of alcohol. This phenomenon is a very frequent experience among alcohol‐consuming people and it has been associated to high socio‐economic costs, mainly due to absenteeism and poor performance in academic and work settings. Multiple theories exist to explain the appearance and severity of hangover, such as direct or indirect effects of alcohol, alcohol withdrawal, and toxic effects of alcoholic beverage congeners or of alcohol metabolites. In addition, a number of intervening factors have been identified, such as vulnerability to alcohol dependence or psychological factors.ConclusionsAlthough several studies analyze and describe hangover, it is still poorly understood. Further well‐designed studies with a unitary methodology and clear operational criteria to define hangover are necessary in order to clarify such a phenomenon. We suggest some future working ideas that should be pursued in order to address the current shortcomings. Copyright © 2009 John Wiley & Sons, Ltd.
Cell‐cycle‐dependent PC‐PLC regulation by APC/CCdc20‐mediated ubiquitin‐proteasome pathway
Authors: Fu Da , Ma Yushui , Wu Wei , Zhu Xuchao , Jia Chengyou , Zhao Qianlei , Zhang Chunyi , Wu Xing Zhong 
Published: April 2009

AbstractPhosphatidylcholine‐specific phospholipase C (PC‐PLC) is involved in the cell signal transduction, cell proliferation, and apoptosis. The mechanism of its action, however, has not been fully understood, particularly, the role of PC‐PLC in the cell cycle. In the present study, we found that cell division cycle 20 homolog (Cdc20) and PC‐PLC were co‐immunoprecipitated reciprocally by either antibody in rat hepatoma cells CBRH‐7919 as well as in rat liver tissue. Using confocal microscopy, we found that PC‐PLC and Cdc20 were co‐localized in the perinuclear endoplasmic reticulum region (the “juxtanuclear quality control” compartment, JUNQ). The expression level and activities of PC‐PLC changed in a cell‐cycle‐dependent manner and were inversely correlated with the expression of Cdc20. Intriguingly, Cdc20 overexpression altered the subcellular localization and distribution of PC‐PLC, and caused PC‐PLC degradation by the ubiquitin proteasome pathway (UPP). Taken together, our data indicate that PC‐PLC regulation in cell cycles is controlled by APC/CCdc20‐mediated UPP. J. Cell. Biochem. 107: 686–696, 2009. © 2009 Wiley‐Liss, Inc.
Down‐regulation of epidermal growth factor receptor induced by estrogens and phytoestrogens promotes the differentiation of U2OS human osteosarcoma cells
Authors: Salvatori Luisa , Caporuscio Francesca , Coroniti Giuseppe , Starace Giuseppe , Frati Luigi , Russo Matteo Antonio , Petrangeli Elisa 
Published: April 2009

AbstractIn previous studies on HeLa cells we demonstrated estrogen‐responsiveness of the epidermal growth factor receptor (EGFR) gene, as 17β‐estradiol (E2) and selective estrogen receptor modulators (SERMs) genistein (G), daidzein (D), and 4‐hydroxytamoxifen (4OH‐T) modulated its transcription in a ligand‐ and estrogen receptor (ER) isoform‐specific way. This study describes further investigations into the role of ERs in mediating the effects induced by E2 and SERMs on EGFR expression, and the relationship between the actions of ERs and EGFR in U2OS osteosarcoma cells stably expressing ERα or ERβ. Cell number and DNA content determination revealed that E2, G, and D inhibited proliferation and cell cycle progression and promoted apoptosis in both cell lines. In parallel, changes in cell morphology typical of osteoblast maturation were observed via optical microscopy. Consistently, quantitative PCR and Western blot analysis showed an up‐regulation of markers of osteoblast differentiation and bone repair, and a decrease in EGFR expression. The transfection of specific antisense (AS) oligonucleotides strengthened our hypothesis that EGFR reduction caused changes in the proliferation/differentiation pattern comparable to those induced by ER ligands. The link between the ER and EGFR pathways was confirmed by treatment with 4OH‐T, which decreased the EGFR level and produced differentiation effects via ERα, but induced both EGFR expression and proliferation effects via ERβ. In conclusion, we show that also in U2OS cells, E2 and SERMs are able to modulate the expression of the EGFR gene and can affect events strictly controlled by its signaling pathway, such as the maturation of osteoblasts. J. Cell. Physiol. 220: 35–44, 2009. © 2009 Wiley‐Liss, Inc.
Mass spectral fragmentation pattern of 2,2‐bipyridyls. Part V. 2,2′‐oxydipyridine
Authors: Keats N. G. , Summers L. A. 
Published: April 2009

AbstractThe mass spectrum of 2,2′‐oxydipyridine obtained by electron impact is reported. The principal fragmentations involve loss of C2IIO and CO in addition to rupture of the central bonds. Molecular rearrangements accompany the fragmentations.
The condensation of ethyl phenylpropiolale with 3‐pyridylacetonitrile
Authors: Al‐Jallo Hikmat N. , Al‐Azawi Fatin 
Published: April 2009

AbstractThe reaction of 3‐pyridylacetonitrile with ethyl phenylpropiolate gave not only the expected 3‐hydroxy‐5‐phenyl‐2‐(3‐pyridyl)pent‐2‐en‐4‐ynenitrile (IX) but also a di‐Michael addition product of one molecule of the pyridylacetonitrile and two molecules of the acetylenic ester, ethyl 4‐earbethoxy‐3,5‐diphenyl‐6‐(3‐pyridyl) anthranilate (IV). Moreover, 2‐elhoxy‐6‐phenyl‐3‐(3‐pyridyl)pyrid‐4‐one (XIV) was also isolated as the eyclization product obtained after the addition of a molecule of ethanol to compound IX. Ir and ninr spectra arc reported for all products.
Unusual products from the synthesis of 3‐(2‐phenylethyl)pyridines by the hydrosulfite reduction of nitrosamines
Authors: Walter Lewis A. , Chang Wei K. , Mcglotten James , Foester Robert 
Published: April 2009

AbstractThe Overberger hydrosulfite reduction of N‐nitroso[(3‐phenylmethylamino)methyl]pyridine gave 3‐(2‐phenylethyl)pyridine and, as determined by nmr, glc and mass spectral studies, about 15% of a mixture which consisted of the 2‐, 4‐, and 6‐(phenylmethyl)‐3‐methylpyridines, and the 3‐[2‐, 3‐, and 4‐(methylphenylmethyl)]pyridines. These by‐products resulted from the coupling of an arylmethyl fragment with the opposite aryl group. A concerted reaction is suggested for the ortho couplings and a radical rearrangement for the para couplings. Authentic samples of three of these by‐products were prepared for comparison. A similar reduction of (+)‐N‐nitroso‐3‐[(phenylethylamino)methyl]pyridine gave (+)3‐(2‐phenylpropyl)pyridine of undetermined optical purity and by‐products which were not examined but whose nmr spectrum indicated them to be of analogous origin.
Synthèse et propriétés des aroylhydrazones du benzoate d'éthyle. Synthèses d'hétéroscycles azotes
Authors: Milcent R. , Redeuilh Et C. 
Published: April 2009

AbstractL'action des aroylhydrazines sur le ehlorhydrate de benziminoéther conduit aux aroyl‐liydrazones du benzoate d'éthyle. Ces composés se cyclisent thermiquemenl ou dans l'alcool en présence de carbonate de sodium pour donner les aryl‐5 phényl‐2 oxadiazoles‐1,3,4 correspondants. L'action de 1′hydrazine conduit aux amino‐4 aryl‐5 phényl‐3 4Htriazoles‐1,2,4 et au diphényl‐3,6 tétrazine‐1,2,4,5. Enfin, L'iodure de méthylmagnésium réagit sur ces hydrazones en formant les aroylhydrazones de L'acétophénone. Les spectres IR, RMN, et UV des nouveaux composés sont étudiés.
Psilocin analogs. 1. Synthesis of 3‐[2‐(dialkylamino)ethyl] ‐and 3‐[2‐(cycloalkylamino)ethyl] indol‐4‐ols
Authors: Repke David B. , Ferguson Wilfred J. , Bates Dallas K. 
Published: April 2009

AbstractThe synthesis of four dialkyl and three eyeloalkyl analogs of psilocin (4, R ‐ CH3), a hallucinogenic principle found in certain fungi, is described. The synthetic route involves four transformations starting with 6,7‐dihydroindol‐4(5H)one: (1).
The photochemical synthesis of novel heterocyclic compounds from s‐triazolo[4,3‐b]pyridazine (II)
Authors: Maas Garren E. , Bradshaw Jerald S. 
Published: April 2009

Abstracts‐Triazolo[4,3‐b Jpyridazine (I) photochemically reacted with dihydropyran; 2,3‐dihydro‐p‐dioxin; 2,5‐dihydrofuran; 2,5‐dimethoxy‐2,5‐dihydrofuran; and 1,3‐dioxep‐5‐ene to give a new series of substituted pyrrolo[1,2‐b]‐.s‐triazoles (II‐IX). In most reactions, two or more products were formed. The following compounds have been prepared from I: 9‐methylene‐4a,5,6,7,8a,9‐hexahydropyrano[2,3 :4,5]pyrrolo[1,2‐b]‐s‐triazole (Ha), the corresponding 9‐cyanomethyl product (III), and 9‐methylene‐4a,7,8,8a‐tetrahydro‐6H,9H‐pyrano[3′,2′:4,5]pyrrolo[1,2‐b]‐s‐triazole (IIb) from dihydropyran; 9‐methylene‐4a,6,7,8a‐tetrahydro‐9H‐p‐dioxino[2′,3′:4,5]‐pyrrolo[1,2‐6]‐s‐triazole (IV) from 2,3‐dihydro‐p‐dioxin; 8‐methylene‐4a,5,7a,8‐tetrahydro‐7H‐furo[3′,4′:4,5]pyrrolo[1,2‐b]‐s‐triazole (V) and the corresponding 8‐cyanomethyl product (VI) from 2,5‐dihydrofuran; 8‐cyanomethyl‐5,7‐dimethoxy‐4a,5,7a,8‐tetrahydro‐7H‐furo[3′,4′:4,5]‐pyrrolo[1,2‐6]‐s‐lriazole (VII) from 2,5‐dimethoxy‐2,5‐dihydrofuran; and 10‐methylene‐4a,5,9a,10‐tetrahydro‐9H‐[1,3]dioxepino[5′,6′:4,5]pyrrolo[1,2‐b]‐s‐triazole (VIII) and the corresponding 10‐cyanomethyl product (IX) from 1,3‐dioxep‐5‐ene. The addition of several other compounds (1,2,3,6‐tetrahydropyridine, 1‐acetylimidazole, 3‐sulfolene, 2,3‐dihydro‐p‐dithiin, and vinylene carbonate) was attempted, but no reactions were observed.
Basc‐catalyzed hydrogen‐deuterium exchange in benzo derivatives of five‐membered aromatic heterocyeles. Part III. A comparative and systematic study of the i‐beuzothiopbene, benzofuran, henzotbiazole and benzoxazole systems
Authors: Allanasi Orazio 
Published: April 2009

AbstractThe rates of base‐catalyzed hydrogen‐deuterium exchange at C‐2 in 1‐benzothiophene, benzofuran, benzothiazole and benzoxazole were studied. For benzothiophene benzofuran the relative second‐order rale constants of hydrogen‐deuterium exchange were 4:1, while for benzothiazole and benzoxazole they were 1:20. These data can be explained by assuming that the sulphur heteroatom interacts electronically with the atom in position 3 of the five‐membered ring. While, very probably, the d‐orbital conjugation cannot depend much on the: atom in position 3, the polarization phenomena can vary more with the atom in position 3. For this reason it was thought that the electronic activity ol the sulphur heleroatom is due to polarization phenomena rather that d‐orbilal interaction.
Synthesis and reactions of 3‐carbethoxy and 3‐aroyl‐3,4‐dihydro‐1h‐2,3‐benzoxazin‐1‐ones
Authors: Trani Aldo , Bellasio Elvio 
Published: April 2009

AbstractA series of 3‐substituted 3,4‐dihydro‐1H‐2,3‐benzoxazin‐1‐ones (IV) (Scheme I) was prepared by reaction of 2‐bromomethylbenzoyl chlorides (II) with N‐hydroxyethylcarbamate (III) or with benzohydroxamic acids. Acid hydrolysis of 3‐carbethoxy (IVa) and 3‐benzoyl derivatives (IVb) afforded a mixture of 2‐(hydroxyaminomethyl)benzoic acid (V) and 2,3‐dihydro‐2‐hydroxy‐1H‐1‐isoindolinone (VII). Compound IVa reacted with ethanol, amines or hydrazine to yield the ethyl ester X, amides XIV (Scheme II) and the hydrazide XII of 2‐(N‐carbethoxy‐N‐hydroxy‐aminomethyl)benzoic acid. Diazotization of the hydrazide XII afforded the unstable azide XIII which did not undergo the Curtius reaction but gave the benzoxazinone IVa by loss of hydrazoic acid.
The reaction of 2‐picoline N‐Oxide with o‐substituled benzoates and lsatoic anhydrides
Authors: Connor David T. , Young Patricia A. , Von Strandtmann Maximillian 
Published: April 2009

AbstractThe reaction of 2‐picoline N‐Oxide anion with o‐substituted henzoates and isatoic anhydrides to give synthetically useful l‐(2‐methoxyphenyl)‐2‐(2‐pyridinyl)ethanone N‐oxides, I‐(2‐hydroxy‐phenyJ)‐2‐(2‐pyridinyl)ethanone N‐oxides and I ‐(2‐arninopheny])‐2‐(2‐pyridinyl)ethanone N‐oxides is described.
Heterocyclic synthesis with N‐oxides. Preparation of pyridine n‐oxide substituted chromones, chromanones, coumarins, quinolones, dihydroquinolones and cinnolones
Authors: Connor David T. , Young Patricia A. , Von Strandtmann Maximillian 
Published: April 2009

AbstractThe synthesis of pyridine N‐oxide substituted chromones, chromanones, coumarins, quinolines, dihydroquinolines and cinnolines from l‐(2‐hydroxyphenyl)‐2‐(2‐pyridinyl)ethanone N‐oxide, 1‐(2‐aminophenyl)‐2‐(2‐pyridinyl)ethanone N‐oxide and 1‐[2‐(methylamino)phenyl]‐2‐(2‐pyri‐dinyl)ethanone N‐oxide is described.
2‐Methylisoxazolin‐5‐ones III. Curboxylic. Acids and their Derivatives
Authors: De Sarlo Francesco , Cencioni Roberto , Renzi Ciovanni , Bausi Letizia 
Published: April 2009

AbstractCarbethoxy‐substituted 12‐methylisoxazolin‐5‐ones and several functional derivatives have been prepared. Spectral properties of the corresponding carboxylic acids are discussed. These acids ant stronger when the carboxy group is in position 3 than when in position 4 of the heterocycle.
Structure and acidity of some heterocyclic nitrosazones
Authors: Shawali Ahmad Sarni 
Published: April 2009

AbstractSeveral new heterocyclic nitrosazones were prepared and their acid dissociation constants determined in 50 volume percent ethanol‐water solution at 25.0 ± 0.1° and μ of 0.10. Infrared, electronic, and pmr spectra of these compounds and some deuterated nitrosazones were also examined and compared with their O‐methyl derivatives. It is concluded that all compounds have the azo oxime structure and that the stereochemistry around the azo group is trans. The data revealed also that the nitrosazones derived from pyridine aldehydes show the existence of equilibria between zwitterionic and neutral molecules. No evidence for the tautomeric nitroso‐hydrazone form could be obtained.
A new, one‐step transformation of furoic acid derivatives to 2‐Amino‐3‐hydroxypyridines
Authors: Greater Hans , Belluš Daniel 
Published: April 2009

Abstract2‐Arnino‐3‐hydroxypyridine and its 6‐methyl derivative can be prepared in yields up to 55% by heating 2‐furoic acid derivatives at 200‐250° with ammonia in the presence of an acidic catalyst. The reaction is preferably conducted in an amide or a nitrile as solvent.
Derivatives of 2,3‐Dihydrocyclopenta[d] pyrido[1,2‐a] pyrimidin‐10(1H)one
Authors: Yale Harry L. 
Published: April 2009

AbstractThe annulation of 2‐amino‐3‐hydroxy‐, 2‐amino‐3‐carboxy‐, and 2‐amino‐3‐methylpyridine with ethyl cyelopenlanone‐2‐earboxylate led to the 5‐hydroxy‐, 2, 5‐carboxy‐, 3, and 5‐methyl‐, 4, derivatives of the 2,3‐dihydrocycloperita[d]pyrido[1,2‐a]pyrimidin‐10(1H) one heterocycle. Alkylation of 2 with α‐bromotolue, ne gave the 5‐benzyloxy derivative.
Diazepines. III. Synthesis of 4H‐Pyrrolo[1,2‐a] thieno[3,2‐f] [1,4] diazepines
Authors: Fujimori Hitoxhi , Kayama Yasutaka , Hara Takeshi , Itoh Kazuhiko , Sunami Tamiko 
Published: April 2009

AbstractThe synthesis of 4H‐pyrrolo[1,2‐a]thieno[3,2‐f] [1,4]diazepines (8) is described. Phthal‐imidomethylfurans 1 were treated with bromine‐methanol to give the dihydrofurans 2, which were hydrolyzed and then liydrogenated over Raney nickel or with zinc‐acetic acid to afford the 1,4‐diketones 5. Condensation of 2‐amino‐3‐benzoylthiophenes 6 with 5 gave 3‐benzoyl‐2‐pyrrolylthiopenes 7. The removal of the phthaloyl group from 7 with hydrazine hydrate and ring closure to the diazepine ring yielded the new heterocycles 8.