bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Prevalence of Hemoglobin S and Glucose‐6‐Phosphate Dehydrogenase Deficiency in Jordanian Newborn
Authors: Talafih Khalid , Hunaiti Abdelrahim A. , Gharaibeh Nayef , Gharaibeh Mohammad , Jaradat Saied 
Published: August 2010

AbstractObjective: The aim of this study was to determine the incidence of HbS and glucose‐6‐phosphate dehydrogenase (G6PD) deficiency in Jordanian newborn.Study Design: A total of 181 male and female babies born at Princess Basma Teaching Hospital, randomly selected, and cord blood samples were collected, and the erythrocyte G6PD activity was measured, and the hemoglobin electrophoresis for blood lysate was conducted and scanned for HbS scanning.Results: The frequencies of two major red cell genetic defects, sickle hemoglobin (HbS) and deficiency G6PD was determined, of the studied subjects 10 (11%) females and 11 (12%) males were found to be deficient in the G6PD gene. The frequency of HbS carriers among the females was 4% while it was 6% among males. The coincidence of both G6PD deficiency and sickle cell hemoglobin in the samples was 1%. No coincidence was found between G6PD deficiency and hyperbilirubinemia.Conclusion: A better understanding of the distributions of these genetic disorders has the potential to aid in the more efficient utilization of health care resources and improved planning.
Pulmonary Embolism Associated with Sjögren's Syndrome in Pregnancy
Authors: Kikuchi Akihiko , Okai Takashi , Taketani Yuji 
Published: August 2010

AbstractThe occurrence of pulmonary embolisms in patients having circulating lupus anticoagulant has been reported.1–3) Lupus anticoagulant has been noticed in association with autoimmune diseases1,4–6) and early‐onset severe preeclampsia.7–10) We report a case of Sjögren's syndrome with circulating lupus anticoagulant in a patient who developed a pulmonary embolism and severe preeclampsia at 29 weeks of gestation.
Assessment of Tubal Patency by Transvaginal Sonographic Hydrotubation with Color Doppler Flow
Authors: Taechakraichana Nimit , Wisawasukmongchol Wirach , Uerpairojkij Boonchai , Suwajanakorn Somchai , Limpaphayom Kobchitt , Phaosawasdi Sukhit 
Published: August 2010

AbstractObjective: To assess the value of transvaginal sonographic hydrotubation with color Doppler flow (TSH) as a test of tubal patency.Methods: Thirty‐nine women undergoing infertility investigation at Chulalongkorn Hospital participated in this prospective, blind comparative study. Before diagnostic laparoscopy (DL) with chromopertubation, TSH was performed using the SSD 680, 5 MHz vaginal ultrasound probe and 20–50 ml of saline was injected into the uterine cavity.Results: Nine cases could not be evaluated properly. Of the 30 cases, there were complete agreements between TSH and DL in 24 (80%), partial agreement in 5 (16.67%) and non‐agreement in 1 (3.33%). TSH had sensitivity 100%; specificity 84.62%, positive predictive value 50%, negative predictive value 100%, false positive rate 15.38%, but no false negative rate.Conclusion: TSH is a simple diagnostic procedure for screening of tubal patency. However, other confirmatory test is needed if tubal occlusion is suspected.
Regulation of Neutrophil Superoxide Generation by Alpha‐Tocopherol in Human Peripheral and Umbilical‐Cord Blood
Authors: Ando Masaki , Yoshioka Tamotsu , Akiyama Jitsuo , Kudo Takafumi 
Published: August 2010

AbstractObjectives: Alfa‐tocopherol (VE) inhibits protein phosphorylation and affects protein kinase C (PKC)‐dependent superoxide (O2‐) generation of phagocytic cells. Because umbilical‐cord blood contains low concentrations of VE, we studied the effects of VE on stimulation‐dependent O2 generation of neutrophils derived from the healthy human peripheral circulation (HPMNs) and the umbilical cord (UCBNs).Methods: O2‐ generation and VE content were assayed by reduction of ferricytochrome c and by HPLC with an electrochemical detector, respectively. Neutrophil‐specific annexin protein was identified by an immunological method.Results: Both types of neutrophils generate significant amounts of PKC‐dependent O2‐ generation, but weak PKC‐independent O2‐ generation, except for opsonized zymosan‐stimulated O2‐ generation in UCBNs. The VE content of UCBNs was similar to that of HPMNs although umbilical‐cord blood contains a low concentration of VE. A neutrophil‐specific annexin protein was also found in the UCBNsConclusion: UCBNs have a greater ability to incorporate VE than HPMNs do, but have similar general characteristics of stimulation‐dependent O2‐ generation to those of HPMNs.
Vitamin D Receptor in Endometrial Carcinoma and the Differentiation‐Inducing Effect of 1,25‐Dihydroxyvitamin D3 on Endometrial Carcinoma Cell Lines
Authors: Yabushita Hiromitsu , Hirata Masato , Noguchi Masayoshi , Nakanishi Masami 
Published: August 2010

AbstractIn view of the potential of 1,25‐dihydroxyvitamin D3 [1,25(OH)2D3] as a cell‐differentiation‐inducing agent in endometrial cancer, the localization of the vitamin D receptor (VDR) was examined immunohistochemically in 21 endometrial adenocarcinoma specimens, and the effect of 1,25(OH)2D3 on cell growth, as well as the phenotypic changes for cell maturation after treatment with 1,25(OH)2D3, was investigated in 2 endometrial carcinoma cell lines (AMEC‐1, RL95‐2). The VDR was detected in 14 of the 21 endometrial carcinoma specimens. The growth of RL95‐2 cells expressing VDR was inhibited to 44% when cultured with 50 nM 1,25(OH)2D3 for 6 days. In contrast, the growth of AMEC‐1 cells not expressing VDR was completely uninhibited even when cultured with 100 nM 1,25(OH)2D3 for 6 days. The RL95‐2 cells exposed to 50 nM 1,25(OH)2D3 for 6 days had an increasing expression for 52.5 kD or 45 kD cytokeratin polypeptide, and they became columnar with pronounced polarity and formed gland‐like structures when cultured in collagen gel. These results suggest that endometrial adenocarcinoma is a target for 1,25(OH)2D3, which appears to function as a cell‐differentiation‐inducing agent for the treatment of endometrial cancer.
Intravenous Immunoglobulin as Primary Therapy or Adjuvant Therapy to Intrauterine Fetal Blood Transfusion: A New Approach in the Management of Severe Rh‐Immunization
Authors: Deka Dipika , Buckshee Kamal , Kinra Geeta 
Published: August 2010

AbstractMaternal high dose intravenous immunoglobulin (IVIG) has shown promise in the management of severe Rh‐immunization. Intravenous immunoglobulin, blocks Fc mediated antibody transport across the placenta and blocks destruction of fetal red cells and reduces maternal antibody levels. We have tried this new therapy in 6 patients with severe Rh‐immunization, with high maternal antibody titres and previous hydrops and intrauterine deaths. Intravenous immunoglobulin was given from 13–18 weeks of gestation 3–4 weekly, till intrauterine transfusion (IUT) or delivery. Intensive fetal monitoring was done. No fetal hydrops or deaths occurred in any of the 6 cases. Only 2 cases needed intrauterine transfusion. IVIG delayed the onset of fetal anemia by 8–17 weeks thus deferring the need for IUT. All pregnancies continued till 32–36 weeks and all 6 babies did well in the neonatal period.
Choriocarcinoma in Infant and Mother: A Case Report
Authors: Andreitchouk Alexandre Evgenievich , Takahashi Osamu , Kodama Hideya , Morita Mamoru , Sankawa Takeru , Saito Ken , Enomoto Katsuhiko , Tanaka Toshinobu 
Published: August 2010

AbstractWe present a case of gestational choriocarcinoma that developed in a pregnant woman with metastases to her baby. In this case, severe anemia and hepatomegaly of the baby were noticed after delivery. Despite intensive treatments, the tumor progressed rapidly, and the baby died at the age of 38 days. Accurate diagnosis was made after autopsy. When the baby's mother visited our hospital again at 4 months postpartum, there were widespread multiple metastases to her lungs and liver. We want to emphasize that if a neonate or infant has anemia and/or hepatomegaly, it is necessary to be aware of the possibility of infantile choriocarcinoma with the presence of an occult tumor in the mother and to examine the mother's and infant's hCG levels immediately.
Small‐Cell Carcinoma of the Endometrium: An Immunohistochemical and Ultrastructural Analysis
Authors: Tsujioka Hiroshi , Eguchi F. , Emoto M. , Hachisuga T. , Kawarabayashi T. , Shirakawa K. 
Published: August 2010

AbstractSmall‐cell carcinoma of the endometrium is a rare neoplasm, and its aggressive behavior has been reported. We report a case of small‐cell carcinoma occurring primarily in the endometrium of a 62‐year‐old woman with postmenopausal vaginal bleeding and lower abdominal pain. The excised uterus showed a necrotic polypoid mass and histologically displayed an endometrial small‐cell carcinoma. Immuno‐histochemically, the tumor cells were positive for cytokeratin, the epithelial membrane antigen, neuron‐specific enolase, and chromogranin, but were negative for the leukocyte common antigen and Grimelius stain. Ultrastructural analysis revealed the presence of dense core granules in the cytoplasm of tumor cells. The patient died 2 months after surgery because of aggressive behavior of the tumor. We wish to distinguish small‐cell carcinoma of the endometrium from conventional epithelial tumors of the endometrium, because of the former's distinctive histopathologic, immunohistochemical, and ultrastructural characteristics.
Dietary Patterns amongst Ethnic Chinese Pregnant Women in Hong Kong
Authors: Wong Helen O. F. , Fung Hedy , Rogers Michael S. 
Published: August 2010

AbstractObjective: To provide baseline data on the food consumption pattern of ethnic Chinese women in Hong Kong during pregnancy, in order to identify any risk of nutritional imbalance in this population.Subjects and Outcome Measures: One hundred and sixty‐seven primagravid ethnic Chinese women attending the antenatal booking clinic at the Prince of Wales Hospital in the New Territories region were recruited. Among the study sample, subjects with less than 7 years of residence in Hong Kong were identified as recent immigrants (n = 25), while the remainder (n = 142) were classified as local. Half of the recent immigrants originated on the Chinese mainland and half from Indonesia. The eating patterns of the entire sample were compared with the intake recommended in the Taiwan Food Guide. Comparisons were made between local and immigrant regarding age, educational standard and consumption of food from each food group.Results: The median intake of meat and meat substitutes was significantly higher than recommendation. There was no significant difference between actual and recommended intake of fruit but the consumption of dairy products, bread and cereals, and vegetables were all significantly below minimum recommendation.Conclusion: The unfavorable dietary pattern reflected that many Chinese pregnant women are still not aware of dietary guidelines and the necessity of modifying their dietary practices in order to achieve the optimal maternal nutrition status. This lack of awareness is more prominently exhibited among the Asian Chinese immigrants.
Acute Myocarditis with Eosinophilia Presenting as Asymmetric Septal Hypertrophy during Pregnancy
Authors: Sagesaka Toshiaki , Liang Shan‐Guang , Morioka Hiromitsu , Watanabe Takaya , Kaibara Manabu , Dohba Nobutaka 
Published: August 2010

AbstractA pregnant female at 24 weeks' gestation developed acute myocarditis with eosinophilia presenting as asymmetric septal hypertrophy. Her clinical course improved with ordinary treatment within a few weeks.
Effect of Oocyte Retrieval from a Small Leading Follicle in Fixed‐Schedule in vitro Fertilization Program
Authors: Nagai Seiichiro , Yasumizu Takehiko , Kasai Tsuyoshi , Hirata Shuji , Mizuno Kaoruko , Kato Junzo 
Published: August 2010

AbstractObjective: To evaluate the propriety of oocyte retrieval (OR) from a small leading follicle during a fixed‐schedule in vitro fertilization (IVF) program.Methods: OR was fixed only to take place on Wednesdays. Gonadotropin‐releasing hormone agonist treatment was initiated on the first day of the cycle, human menopausal gonadotrophin was given for 7 days starting on the next Monday, and human chorionic gonadotrophin (hCG) was given on the Tuesday before the OR. Patients were divided into 2 groups according to the follicular size observed before the day of hCG administration: Group 1 (141 cycles), with follicles > 16 mm in mean diameter; and Group 2 (38 cycles) with follicles of 10 to 16 mm in mean diameter.Results: Fertilization rates and the incidence of mature oocytes were higher in Group 1 than in Group 2. However, the mean number of oocytes recovered and pregnancy rates were similar in the 2 groups.Conclusion: It is worthwhile to retrieve the oocyte from a small leading follicle in a fixed‐schedule IVF program.
Thromboembolism Treated with Low Molecular Weight Heparin in a Pregnancy Complicated by Major Placenta Praevia: A Case Report
Authors: Rowlands Shelley , Lahoud Robert , Hertzberg Mark , Nicholl Michael 
Published: August 2010

AbstractThe concurrent problems of bleeding placenta praevia and thromboembolism present a difficult management problem. We present a case of pulmonary embolism successfully treated with low molecular weight heparin in a woman with a major grade placenta praevia, who required emergency operative delivery.
Elevated Serum Levels of the c‐erbB‐2 Encoded Oncoprotein Fragment in Cases of Pure Preeclampsia and HELLP Syndrome
Authors: Meden Harald , Mielke Stephan , Wuttke Wolfgang , Kuhn Walther 
Published: August 2010

AbstractObjective: During normal human ontogenesis an overexpression of the c‐erbB‐2 encoded oncoprotein p185 (HER2/neu) occurs in the placenta and on fetal epithelial cells. It is accompanied by the increase of a 105 kD fragment (p105) in both maternal serum and cord blood. We examined whether p105 levels in maternal serum! are influenced by destructions of placental tissue, fetal growth disturbances and placental circulation disorders.Methods: We analysed p105 serum concentrations in patients with abortion (n = 25), ectopic pregnancy (n = 5), intrauterine growth retardation (n = 9), pregnancy induced hypertension (n = 24) and compared them with normal pregnancies of a corresponding gestational age.Results: Patients with abortions showed normal p105 values. Intrauterine growth retardation was associated with lower p105 levels (p < 0.05) whereas patients with pure preeclampsia (p < 0.001) and HELLP syndrome (p < 0.05) had significantly higher levels.Conclusion: The elevation of p105 in sera of preeclamptic women could be due to an increased fetomaternal transfer of p105.
Vaginal Delivery in the Grand Multipara following Previous Lower Segment Cesarian Section
Authors: Dyack Colin , Hughes Philip F. , Simbakalia Janet B. 
Published: August 2010

AbstractObjective: To examine the effect of attempting vaginal birth after cesarian section in the grand multipara with one previous cesarian section scar in the uterus.Method: Over 5‐year period (1990–1994) mothers with 6 or more previous deliveries and with a previous section scar in the uterus were identified. The outcome in these patients who attempted vaginal birth was reviewed.Results: Of the 85 patients with the combination of both grand multiparity and a previous cesarian section scar in the uterus, 45 attempted a trial of labor. Twenty‐seven patients (60%) achieved successful uncomplicated vaginal delivery. There was a relatively high incidence of serious complications.Conclusion: Vaginal birth after cesarian section can be achieved in some grand multiparas with a previous scar in the uterus. There is an increased risk of serious complications. The labor should be very closely supervised and early intervention arranged if there is not smooth rapid progress.
Effects of Transforming Growth Factor‐β on the Production of Parathyroid Hormone‐Related Peptide in a Human Ovarian Cancer Cell Line in vitro
Authors: Yasui Toshiyuki , Uemura Hirokazu , Irahara Minoru , Aono Toshihiro 
Published: August 2010

AbstractObjective: We examined the effects of transforming growth factor‐β1 (TGF‐β1) on intracellular parathyroid hormone‐related peptide (PTHrP) production in a human ovarian cancer cell line (HOC‐21).Methods: Various concentrations of TGF‐β1 were added to a culture medium, and the numbers of cells were counted. HOC‐21 cells were cultured with or without TGF‐4bT1, and intracellular PTHrP was measured by a radioimmunoassay kit that recognized the carboxy‐terminal protein while counting the number of cells. Furthermore, a 125I‐TGF‐β1 binding assay was carried out. Values were analyzed statistically using an analysis of variance followed by an unpaired t‐test.Results: Five ng/m/ of TGF‐β1 inhibited the cell growth on Day 1 after plating. The TGF‐β1 significantly (p < 0.05) stimulated intracellular PTHrP production in a time‐dependent manner, also by Day 1. A 125I‐TGF‐β1 binding study revealed that HOC‐21 cells expressed a high affinity for the TGF‐β1 receptor.Conclusion: The suppression of human ovarian cancer cell proliferation by TGF‐β1 might be involved in the production of PTHrP.
First‐Trimester Detection of Amniotic Sac in Relation to Miscarriage
Authors: Ikegawa Akira 
Published: August 2010

AbstractObjectives: The purposes of this study were to make clear the amniotic sac detection rate, and to determine whether the detection of an amniotic sac can effectively predict miscarriage in the first trimester.Study Design: This study included 169 normal pregnancy cases and 169 miscarriage cases. Both groups consisted of cases with a crown‐rump length (CRL) of less than 40 mm.Results: In normal pregnancies, the amniotic sac was detectable at a CRL of 7 mm, or longer, and its detection rate varied proportionately with the length of the crownrump. In the miscarriage cases, the detection of an amniotic sac was possible at a CRL of less than 7 mm, and it was independent of the length of the crown rump. At a CRL of less than 7 mm, the amniotic sac was detected in 6 miscarriage cases, and the amniotic sac size increased after embryonic death in 19 miscarriage cases. The amniotic sac detection rate was 38% (65 cases) in all miscarriage cases.Conclusion: Detection of an amniotic sac might be one of the useful signs indicating miscarriage when the CRL is less than 7 mm, at which point detection in normal cases is not yet possible.
Laparoscopic Colposuspension in Women with Previously Failed Anti‐Incontinence Surgery
Authors: Foote Andrew J. , Lam Alan 
Published: August 2010

AbstractObjectives: To assess the effectiveness of laparoscopic colposuspension after previously failed anti‐incontinence surgery.Methods: Retrospective review of 10 cases, all with urodynamically proven grade 2 genuine stress incontinence.Results: All patients were subjectively cured at 3 months or more follow‐up. The mean hospital stay was 2.9 days, the mean time until normal voiding was 1.7 days, and the mean blood loss was 39 ml.Conclusion: Laparoscopic colposuspension may be useful after failed anti‐incontinence surgery. However, larger numbers are needed with objective longer term follow‐up.
Is There a Need to Treat Hypokalaemia Associated with Intravenous Salbutamol Infusion?
Authors: Chua S. , Razvi K. , Wong M. T. , Tay R. , Arulkumaran S. 
Published: August 2010

AbstractObjectives: To investigate the evolution of metabolic effects associated with intravenous salbutamol infusion given together with 2 doses of intramuscular steroids in the treatment of preterm labourMethods: Preterm labour was inhibited with an intravenous infusion of salbutamol m 8 women between 26 and 32+6 weeks with normal singleton pregnancies. Serum glucose concentration, serum potassium, sodium and insulin concentrations, and total white cell count both during the infusion as well as post‐therapy, were plotted against time.Results: Intravenous salbutamol infusion administered at a rate required to inhibit uterine contractions in preterm labour causes a rise in serum glucose and plasma insulin concentrations. The serum glucose and plasma insulin levels peaked soon after cessation of therapy and took 2–3 hours to come to pre‐infusion levels. The decline in serum potassium concentration was gradual and plateaued after 2 hours. Once the salbutamol infusion was stopped the potassium levels were back to normal by 2 hours. There is an increase in total white cell count within an hour of the initation of therapy.Conclusion: There is no need to administer insulin for hyperglycaemia and/or potassium for hypokalaemia unless the patient is a known diabetic or when a patient needs immediate surgery.
Diffuse Cystic Change of a Term Placenta with a Normal Newborn
Authors: Uemura Naoko , Kobayashi Fuminori , Korita Daizo , Tanada Shozo , Niwa Hayato , Nanbu Kanako , Konishi Ikuo , Sagawa Norimasa , Mori Takahide 
Published: August 2010

AbstractWe recently encountered a case of term placenta with a diffuse cystic lesion of the villi.A 19‐year‐old primipara at 36 weeks of gestation underwent cesarean section due to breech presentation with premature rupture of the membranes; she delivered a mature male baby of 2,502 g with an Apgar score of 9/9. The placenta was 940 g in weight and 29 × 20 × 3 cm in size, and macroscopically had multiple cystic lesions (3–8 mm in diameter) that resembled hydatidiform moles. However, histopathological examination revealed that the severe hydropic change was localized in the stem villi but not remarkable in the terminal chorionic villi. Moreover, abnormal proliferation of the trophoblast was not observed. However, the hypertrophic change was observed in the vascular wall of stem villi, in which hyperplasia of smooth muscle‐like cells was present. The urinary hCG levels at 1 month and 2 months after delivery were less than 50 IU/Z. These findings indicate that the multiple cystic lesions of the placenta in this case are essentially different from those of a trophoblastic disease, and that the diffuse cystic lesion of the villi might have been secondary to changes in the local circulation.
Statistical Analysis of Perinatal Outcomes in Pregnancy Complicated with Diabetes Mellitus
Authors: Zhu Liping , Nakabayashi Masao , Takeda Yoshihiko 
Published: August 2010

AbstractObjective: To evaluate the outcomes of pregnancies complicated with diabetes mellitus (DM) in the maternal and perinatal center of Tokyo Women's Medical College (TWMC), and compare the results with reports of other countries.Methods: A retrospective study of 482 cases of DM pregnancies were included over a 13‐year period in a tertiary care hospital in Tokyo. Information were obtained from medical records of both mothers and babies.Results: The prevalence of pregnancies complicated with DM was 5.1%. Preeclampsia developed in 124 cases at a rate of 25.8%. Incidence of preterm delivery was 16.6%. Caesarean sections were performed in 36.7% patients. There were significant differences of caesarean section rates between diabetic complication group (retinopathy and nephropathy) and non‐complication group (69.5% vs 30.5%, p < 0.0001), and between preterm and term deliveries (60.0% vs 32.1%, p < 0.0001). Maternal backgrounds significantly involved with preterm delivery were DM nephropathy and severe preeclampsia. Babies with heavy for gestational age (HGA) were observed at a rate of 21% in all. There were 3 perinatal deaths (intrauterine fetal deaths, IUFD) with the perinatal mortality rate of 6.1/1,000 births. The incidence of caesarean section and perinatal mortality rate of non‐DM pregnancies in our center during the same study period were 16.3% and 7.7/1,000 births respectively.Conclusions: The perinatal outcome in our study was better compared to other worldwide reports. With accurate perinatal management, perinatal mortality rate of DM pregnancies in the current study was almost same as that of non‐DM pregnancies in our center. The main factors to promote adverse perinatal outcomes were presence of DM nephropathy and severe preeclampsia.