bluuebunny/crossref_metadata_2025_split huggingface dataset:
Simultaneous resolution of reactive radioactive decay, non-isothermal flow, and migration with application to the performance assessment for HLW repositories
Authors: Juncosa R. , Font I. , Delgado J. 
Published: May 2010

Abstract
Radioactive decay is an important subject to take into account when studying the thermo-hydro-dynamic behavior of the buffer clay material used in the containment of radioactive waste. The modern concepts for the multibarrier design of a repository of high level waste in deep geologic formations consider that once canisters have failed, the buffer clay material must ensure the retention and/or delay of radionuclides within the time framework given in the assessment studies. Within the clay buffer, different chemical species are retarded/fixed according to several physicochemical processes (ion exchange, surface complexation, precipitation, matrix diffusion, ...) but typical approaches do not consider the eventuality that radioactive species change their chemical nature (i.e. phase) thereby affecting their reactive behavior.
The radioactive decay of an element takes place independently of the phase (aqueous, solid or gaseous) to which it belongs. This means that, in terms of radionuclide fixation, some geochemical processes will be effective scavengers (for instance mineral precipitation of crystal growth) while others will not (for instance ion exchange and/or sorption).
In this contribution we present a reactive radioactive decay model of any number of chemical components including those that belong to decay series. The model, which is named FLOW-DECAY, also takes into account flow and isotopic migration and it has been applied considering a hypothetical model scenario provided by the project ENRESA 2000 and direct comparison with the results generated by the probabilistic code GoldSim. Results indicate that FLOW-DECAY may simulate the decay processes in a similar way that GoldSim, being the differences related to factors associated to code architecture.
The inflow of uranium 234U and 238U from the Vistula River catchment area to the Baltic Sea
Authors: Skwarzec Bogdan , Jahnz-Bielawska Annna , Borylo Alicja 
Published: May 2010

Abstract
In the study, the activities of uranium 234U and 238U in the Vistula River water samples which were collected from November 2002 to October 2003, were measured using alpha spectrometry. In winter, the highest concentration of uranium isotopes and total uranium was in the Vistula River water from Malbork (13.13±0.22 Bq m−3 for 234U, 12.45±0.21 Bq m−3 for 238U and 1.02±0.30 mg m−3 for total uranium), and the lowest was in water from Dęblin (1.73±0.07 Bq m−3 for 234U, 1.55±0.07 Bq m−3 for 238U and 0.13±0.09 mg m−3 for total uranium). In analyzed river samples uranium isotopes 234U and 238U are not in the radioactive equilibrium state. The values of 234U/238U activity ratio lie between 1.05–1.70. During spring, the highest concentration of uranium isotopes and total uranium was found in the Vistula River water from Malbork (12.36±0.19 Bq m−3 for 234U, 10.77±0.17 Bq m−3 for 238U and 0.88±0.25 mg m−3 for total uranium), and the lowest was in water taken from Sandomierz (5.77±0.14 Bq m−3 for 234U) and Kraków (4.08±0.11 Bq m`−3 for 238U and 0.33±0.18 mg m−3 for total uranium). The values of 234U/238U activity ratio lie between 1.15–1.64. In summer, the highest concentration of uranium isotopes and total uranium was found in the Vistula River water samples taken from Malbork (8.22±0.21 Bq m−3 for 234U, 7.60±0.21 Bq m−3 for 238U and 0.62±0.29 mg m−3 for total uranium), and the lowest was in water from Sandomierz (6.37±0.12 Bq m−3 for 234U) and Kraków (3.56±0.19 Bq m−3 for 238U and 0.29±0.33 mg m−3 for total uranium). The values of 234U/238U activity ratio lie between 1.08–1.95. In autumn the highest concentration of uranium isotopes and total uranium was in the Vistula River water from Malbork (17.80±0.25 Bq m−3 for 234U, 15.12±0.23 Bq m−3 for 238U and 1.23±0.34 mg m−3 for total uranium) and the lowest was in water from Toruń (8.15±0.49 Bq m−3 for 234U) and Kraków (6.34±0.47 Bq m−3 for 238U and 0.52±0.78 mg m−3 for total uranium). The values of 234U/238U activity ratio lie between 1.10–1.74. Annually, the southern Baltic Sea is enriched by about 507 GBq uranium isotopes 234U and 238U, with 490 GBq going to the Gdańsk Bay and 16.5 GBq to Vistula Lagoon. The highest surface 238U runoff was observed in spring (to 1200 kBq km−2 quarter−1 for catchment´s area), the lowest in summer for Bug with Narew catchment´s area to 20 kBq km−2 quarter−1). These studies are very important for the inflow estimation of natural and anthropogenic alpha radionuclides to the Baltic Sea.
Comparison of pharmacodynamic intrasubject variability of insulin lispro protamine suspension and insulin glargine in subjects with type 1 diabetes
Authors: Ocheltree S M , Hompesch M , Wondmagegnehu E T , Morrow L , Win K , Jacober S J 
Published: May 2010

ObjectiveThe objective of the study was to evaluate pharmacodynamic (PD) intrasubject variability of a single, s.c. dose of insulin lispro protamine suspension (ILPS) compared with insulin glargine in subjects with type 1 diabetes mellitus and additionally, to compare the intrasubject variability of pharmacokinetic parameters of both insulins.DesignThis was a single-center, investigator-blinded and subject-blinded, two-arm, parallel, randomized, four-period study. During the replicate visits, subjects received a single s.c. 0.6 U/kg dose of either ILPS or glargine, and underwent 24-h euglycemic glucose clamps.ResultsThe intrasubject variabilities of the primary PD parameters, total amount of glucose infused (Gtot) and maximum glucose infusion rate (GIR; Rmax), were statistically significantly lower for ILPS when compared with glargine (P<0.0001). Least-square (LS) mean estimates for Gtot and Rmax were 2512.7 mg/kg and 3.740 mg/min per kg respectively for ILPS, and 1291.9 mg/kg and 1.793 mg/min per kg respectively for glargine. The LS mean estimates for Gtot and Rmax were statistically greater (P=0.0010 and P<0.0001 respectively) for ILPS compared with glargine, suggesting that ILPS had greater 24-h glucose-lowering activity. Glargine demonstrated a flatter GIR–time curve, and ILPS demonstrated a significantly shorter time of maximum GIR (tRmax) and earlier time to half-maximal GIR before tRmax and time to half-maximal GIR after tRmax. ILPS administration resulted in significantly greater exposure compared with glargine (area under the baseline-corrected serum concentration versus time curve from time 0 to 24 h (AUC0–24): 77 150 vs 53 111 pmol min/l; maximum serum insulin concentration (Cmax): 119 vs 68 pmol/l; ILPS versus glargine respectively), but the intrasubject variabilities for AUC and Cmax were comparable.ConclusionAlthough glargine demonstrated a flatter GIR–time profile, the lower PD intrasubject variability of ILPS may provide a more predictable response.
Review on Quality of Life Issues in Patients with Primary Brain Tumors
Authors: Taphoorn Martin J.B. , Sizoo Eefje M. , Bottomley Andrew 
Published: May 2010

Abstract
Health-related quality of life (HRQOL) has become an important outcome measure in clinical trials in primary brain tumor (i.e., glioma) patients, because they have an incurable disease. HRQOL is assessed using self-reported, validated questionnaires, addressing physical, psychological, emotional, and social issues. In addition to generic HRQOL instruments, disease-specific questionnaires have been developed, including for brain tumor patients. For the analysis and interpretation of HRQOL measurements, low compliance and missing data are methodological challenges.
HRQOL in glioma patients may be negatively affected by the disease itself as well as by side effects of treatment. But treatment with surgery, radiotherapy, and chemotherapy may improve patient functioning and HRQOL, in addition to extending survival.
Although HRQOL has prognostic significance in brain tumor patients, it is not superior to well-known clinical parameters, such as age and performance status. In clinical practice, assessing HRQOL may be helpful in the communication between doctor and patient and may facilitate treatment decisions.
Using a Case Report of a Patient With Spinal Cord Injury to Illustrate the Application of the International Classification of Functioning, Disability and Health During Multidisciplinary Patient Management
Authors: Rauch Alexandra , Escorpizo Reuben , Riddle Daniel L. , Eriks-Hoogland Inge , Stucki Gerold , Cieza Alarcos 
Published: May 2010

Background and PurposePhysical therapists require a comprehensive assessment of a patient's functioning status to address multiple problems in patients with severe conditions. The International Classification of Functioning, Disability and Health (ICF) is the universally accepted conceptual model for the description of functioning. Documentation tools have been developed based on ICF Core Sets to be used in multidisciplinary rehabilitation management and specifically by physical therapists. The purposes of this case report are: (1) to apply ICF-based documentation tools to the care of a patient with spinal cord injury and (2) to illustrate the use of ICF-based documentation tools during multidisciplinary patient management.Case DescriptionThe patient was a 22-year-old man with tetraplegia (C2 level) who was 5 months postinjury. The report describes the integration of the ICF-based documentation tools into the patient's examination, evaluation, prognosis, diagnosis, and intervention while he participated in a multidisciplinary rehabilitation program for 2 months.OutcomesThe patient's comprehensive functioning status at the beginning of the program, the rehabilitation goals, the intervention plan, and his improvements in functioning following rehabilitation and the according goal achievement were illustrated with physical therapy–specific and multidisciplinary ICF-based documentation tools.DiscussionThis case report illustrates how the ICF-based documentation template for physical therapists summarizes all relevant information to aid the physical therapist's patient management and how ICF-based documentation tools for multidisciplinary care complement one another and thus can be used to enhance multidisciplinary patient management. In addition, the ICF assists in clarifying clinician roles as part of a multidisciplinary team. The case report demonstrates that the ICF can be a viable framework both for physical therapy and multidisciplinary management and for clinical documentation.
Ponatinib vs Imatinib in Frontline Philadelphia Chromosome–Positive Acute Lymphoblastic Leukemia
Authors: Jabbour Elias , Kantarjian Hagop M. , Aldoss Ibrahim , Montesinos Pau , Leonard Jessica T. , Gómez-Almaguer David , Baer Maria R. , Gambacorti-Passerini Carlo , McCloskey James , Minami Yosuke , Papayannidis Cristina , Rocha Vanderson , Rousselot Philippe , Vachhani Pankit , Wang Eunice S. , Wang Bingxia , Hennessy Meliessa , Vorog Alexander , Patel Niti , Yeh Tammie , Ribera Jose-Maria 
Published: May 2024

ImportanceIn newly diagnosed Philadelphia chromosome–positive (Ph+) acute lymphoblastic leukemia (ALL), disease progression due to acquired resistance to first- or second-generation BCR::ABL1 tyrosine kinase inhibitors is common. Ponatinib inhibits BCR::ABL1 and all single-mutation variants, including T315I.ObjectiveTo compare frontline ponatinib vs imatinib in adults with newly diagnosed Ph+ ALL.Design, Setting, and ParticipantsGlobal registrational, phase 3, open-label trial in adults aged 18 years or older with newly diagnosed Ph+ ALL. From January 2019 to May 2022, eligible patients at 77 sites were randomized 2:1 to ponatinib (30 mg/d) or imatinib (600 mg/d) with reduced-intensity chemotherapy, followed by single-agent ponatinib or imatinib after the cycle 20 phase of the trial. The last date of follow-up for this analysis was August 12, 2022.InterventionPatients received ponatinib, 30 mg/d, or imatinib, 600 mg/d, with reduced-intensity chemotherapy, followed by single-agent ponatinib or imatinib after cycle 20. The ponatinib dose was reduced to 15 mg on achievement of minimal residual disease–(MRD) negative complete remission.Main Outcomes and MeasuresThe primary end point of this interim analysis was MRD-negative complete remission (≤0.01% BCR::ABL1 [MR4] centrally assessed by reverse transcriptase–quantitative polymerase chain reaction), with complete remission maintained for at least 4 weeks at the end of cycle 3. The key secondary end point was event-free survival.ResultsOf 245 patients randomized (median age, 54 years; 133 [54.3%] female), 232 (ponatinib, n = 154; imatinib, n = 78) who had p190 or p210 dominant isoforms verified by the central laboratory were analyzed for the primary end point. The MRD-negative complete remission rate (primary end point) was significantly higher with ponatinib (34.4% [53/154]) vs imatinib (16.7% [13/78]) (risk difference, 0.18 [95% CI, 0.06-0.29]; P = .002). At the data cutoff, event-free survival had not met the prespecified number of events. Median event-free survival was not reached in the ponatinib group and was 29 months in the imatinib group. The most common adverse events were similar between treatment groups. Arterial occlusive events were infrequent and comparable between groups (ponatinib, 2.5%; imatinib, 1.2%).Conclusions and RelevancePonatinib demonstrated a superior rate of MRD-negative complete remission at the end of induction vs imatinib when combined with reduced-intensity chemotherapy in adults with newly diagnosed Ph+ ALL. The safety profile of ponatinib was comparable with imatinib.Trial RegistrationClinicalTrials.gov Identifier: NCT03589326
Causal Inference About the Effects of Interventions From Observational Studies in Medical Journals
Authors: Dahabreh Issa J. , Bibbins-Domingo Kirsten 
Published: May 2024

ImportanceMany medical journals, including JAMA, restrict the use of causal language to the reporting of randomized clinical trials. Although well-conducted randomized clinical trials remain the preferred approach for answering causal questions, methods for observational studies have advanced such that causal interpretations of the results of well-conducted observational studies may be possible when strong assumptions hold. Furthermore, observational studies may be the only practical source of information for answering some questions about the causal effects of medical or policy interventions, can support the study of interventions in populations and settings that reflect practice, and can help identify interventions for further experimental investigation. Identifying opportunities for the appropriate use of causal language when describing observational studies is important for communication in medical journals.ObservationsA structured approach to whether and how causal language may be used when describing observational studies would enhance the communication of research goals, support the assessment of assumptions and design and analytic choices, and allow for more clear and accurate interpretation of results. Building on the extensive literature on causal inference across diverse disciplines, we suggest a framework for observational studies that aim to provide evidence about the causal effects of interventions based on 6 core questions: what is the causal question; what quantity would, if known, answer the causal question; what is the study design; what causal assumptions are being made; how can the observed data be used to answer the causal question in principle and in practice; and is a causal interpretation of the analyses tenable?Conclusions and RelevanceAdoption of the proposed framework to identify when causal interpretation is appropriate in observational studies promises to facilitate better communication between authors, reviewers, editors, and readers. Practical implementation will require cooperation between editors, authors, and reviewers to operationalize the framework and evaluate its effect on the reporting of empirical research.
Place-Based Measures of Inequity and Vision Difficulty and Blindness
Authors: Hicks Patrice M. , Lin George , Newman-Casey Paula Anne , Niziol Leslie M. , Lu Ming-Chen , Woodward Maria A. , Elam Angela R. , Musch David C. , Mehdipanah Roshanak , Ehrlich Joshua R. , Rein David B. 
Published: May 2024

ImportanceKnown social risk factors associated with poor visual and systemic health in the US include segregation, income inequality, and persistent poverty.ObjectiveTo investigate the association of vision difficulty, including blindness, in neighborhoods with measures of inequity (Theil H index, Gini index, and persistent poverty).Design, Setting, and ParticipantsThis cross-sectional study used data from the 2012-2016 American Community Survey and 2010 US census tracts as well as Theil H index, Gini index, and persistent poverty measures from PolicyMap. Data analysis was completed in July 2023.Main Outcomes and MeasuresThe main outcome was the number of census tract residents reporting vision difficulty and blindness (VDB) and the association with the Theil H index, Gini index, or persistent poverty, assessed using logistic regression.ResultsIn total, 73 198 census tracts were analyzed. For every 0.1-unit increase in Theil H index and Gini index, there was an increased odds of VDB after controlling for census tract–level median age, the percentage of the population that identified as female sex, the percentage of the population that identified as a member of a racial or ethnic minority group, state, and population size (Theil H index: odds ratio [OR], 1.14 [95% CI, 1.14-1.14; P &amp;lt; .001]; Gini index: OR, 1.15 [95% CI, 1.15-1.15; P &amp;lt; .001]). Persistent poverty was associated with an increased odds of VDB after controlling for census tract–level median age, the percentage of the population that identified as female sex, the percentage of the population that identified as a member of a racial or ethnic minority group, state, and population size compared with nonpersistent poverty (OR, 1.36; 95% CI, 1.35-1.36; P &amp;lt; .001).Conclusions and RelevanceIn this cross-sectional study, residential measures of inequity through segregation, income inequality, or persistent poverty were associated with a greater number of residents living with VDB. It is essential to understand and address how neighborhood characteristics can impact rates of VDB.
Resorcinol‐Phthalaldehyde Resins for Photosynthesis of Hydrogen Peroxide: Modulation of Electronic Structure and Integration of Dual Channel Pathway
Authors: Chen Zhong , Chu Chengcheng , Yao Ducheng , Li Qiuju , Mao Shun 
Published: May 2024

AbstractModulating of electronic structure of photocatalyst and integration of dual channel pathway are promising strategy for efficient photosynthesis of hydrogen peroxide (H2O2) from pure water without sacrificial agent and oxygen exposure. In this work, nontoxic aromatic dialdehyde is used to replace the commonly used toxic formaldehyde to form resorcinol‐phthalaldehyde resins through a hydrothermal method. The introducing of aromatic ring as π spacer increases the separation distance of electrons and holes to avoid their recombination. H2O2 can be produced via integrated oxygen reduction reaction (ORR) and water oxidation reaction (WOR) due to the suitable energy band positions and spatially separated reaction sites. Resorcinol‐p‐phthalaldehyde (RP) resin exhibits a promising H2O2 yield of 3351 µmol g−1 h−1 with high apparent quantum yield (AQY) of 14.9% at 420 nm and solar‐to‐chemical conversion (SCC) efficiency of 1.54%. This work provides a simple strategy to modulate the charge separation efficiency and redox reaction pathway on photocatalyst at molecular level design.
Cross‐Scale Synergistic Manipulation of Dielectric Genes in Polymetallic Sulfides from Micropolarization to Macroconductance Toward Wide‐Band Microwave Absorption
Authors: Cheng Junye , Li Yao , Raza Hassan , Che Renchao , Jin Yongheng , Ye Shulong , Wang Shun , Zhang Deqing , Zheng Guangping 
Published: May 2024

AbstractRecently, the design and development of efficient microwave absorbents by facile engineering approaches have attracted much attention. Particularly, some unique structures caused by cross‐scale design are promising in enhancing the absorbing capability toward microwave irradiation. Herein, the cross‐scale design strategy is implemented to enhance the electromagnetic wave absorption performance of polymetallic sulfides (PMS). In PMS, the dipole polarization unit is optimized, and the distribution of electronic states is improved by doping Ti atoms; Meanwhile, the MS/M3S4 homogeneous hetero‐phases interfaces is constructed in PMS using a phase separation strategy; and the conductivity of PMS is modulated by the addition of acetylene black (ACET). The cross‐scale synergy of microwave absorption leads to a significant enhancement of the microwave absorption (MA) performance of PMS/ACET composites. The optimal reflection loss value of Ti‐LES with 10% ACET addition reaches −55.49 dB and the effective absorption bandwidth reaches 6.73 GHz. The 17.5% ACET‐conditioned Ti‐HES achieves a reflection loss of −37.2 dB at a low frequency of 4.8 GHz. This study not only provides a novel strategy for the development of new broadband MA materials but also validates a new idea for the multi‐scale synergistic optimization of MA materials.
Injectable Thermosensitive Gel CH‐BPNs‐NBP for Effective Periodontitis Treatment through ROS‐Scavenging and Jaw Vascular Unit Protection
Authors: Wang Yuli , Yuan Yuqing , Wang Ruyu , Wang Tianxiao , Guo Fanyi , Bian Yifeng , Wang Tianyao , Ma Qian , Yuan Hua , Du Yifei , Jin Jianliang , Jiang Huijun , Han Feng , Jiang Jiandong , Pan Yongchu , Wang Lulu , Wu Fan 
Published: May 2024

AbstractPeriodontitis, a prevalent inflammatory condition in the oral cavity, is closely associated with oxidative stress‐induced tissue damage mediated by excessive reactive oxygen species (ROS) production. The jaw vascular unit (JVU), encompassing both vascular and lymphatic vessels, plays a crucial role in maintaining tissue fluid homeostasis and contributes to the pathological process in inflammatory diseases of the jaw. This study presents a novel approach for treating periodontitis through the development of an injectable thermosensitive gel (CH‐BPNs‐NBP). The gel formulation incorporates black phosphorus nanosheets (BPNs), which are notable for their ROS‐scavenging properties, and dl‐3‐n‐butylphthalide (NBP), a vasodilator that promotes lymphatic vessel function within the JVU. These results demonstrate that the designed thermosensitive gel serve as a controlled release system, delivering BPNs and NBP to the site of inflammation. CH‐BPNs‐NBP not only protects macrophages and human lymphatic endothelial cells from ROS attack but also promotes M2 polarization and lymphatic function. In in vivo studies, this work observes a significant reduction in inflammation and tissue damage, accompanied by a notable promotion of alveolar bone regeneration. This research introduces a promising therapeutic strategy for periodontitis, leveraging the unique properties of BPNs and NBP within an injectable thermosensitive gel.