bluuebunny/crossref_metadata_2025_split huggingface dataset:
Repeat Single-Session Stereotactic Radiosurgery for Cerebral Arteriovenous Malformations: A Systematic Review, Meta-Analysis, and International Stereotactic Radiosurgery Society Practice Guidelines
Authors: Shaaban Ahmed , Tos Salem M. , Mantziaris Georgios , Kotecha Rupesh , Fariselli Laura , Gorgulho Alessandra , Levivier Marc , Ma Lijun , Paddick Ian , Pollock Bruce E. , Regis Jean , Suh John H. , Yomo Shoji , Sahgal Arjun , Sheehan Jason P. 
Published: June 2024

BACKGROUND AND OBJECTIVES:
Repeat stereotactic radiosurgery (SRS) for residual arteriovenous malformations (AVMs) can be considered as a salvage approach after failure of initial SRS. There are no published guidelines regarding patient selection, timing, or SRS parameters to guide clinical practice. This systematic review aimed to review outcomes and complications from the published literature to inform practice recommendations provided on behalf of the International Stereotactic Radiosurgery Society.

METHODS:
We performed a systematic review and meta-analysis following Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. A comprehensive search of MEDLINE, Scopus, Web of Science, and Embase was conducted. Fourteen studies with 925 patients met the inclusion criteria. Patients were treated between 1985 and 2022. All studies were retrospective, except for one prospective cohort.

RESULTS:
The median patient age at repeat SRS ranged from 32 to 60 years. Four studies (630 patients) reported detailed information on Spetzler–Martin grade at the time of repeat SRS; 12.54% of patients had Spetzler–Martin grade I AVMs (79/630 patients), 46.51% had grade II (293/630), 34.92% had grade III (220/630), 5.08% had grade IV (32/630), and 0.95% had grade V (6/630). The median prescription doses varied between 15 and 25 Gy (mean, 13.06-22.8 Gy). The pooled overall obliteration rate at the last follow-up after repeat SRS was 59% (95% CI 51%-67%) with a median follow-up between 21 and 50 months. The pooled hemorrhage incidence at the last follow-up was 5% (95% CI 4%-7%), and the pooled overall radiation-induced change incidence was 12% (95% CI 7%-20%).

CONCLUSION:
For an incompletely obliterated AVM, repeat radiosurgery after 3 to 5 years of follow-up from the first SRS provides a reasonable benefit to the risk profile. After repeat SRS, obliteration is achieved in the majority of patients. The risk of hemorrhage or radiation-induced change appears low, and International Stereotactic Radiosurgery Society recommendations are presented.
Association of Glymphatic and White Matter Impairment With the Postoperative Outcome of Pediatric Hydrocephalus
Authors: Zhao Cailei , OuYang YiPing , Zhang Gongwei , Zang Dongdong , Xia Jun , Liang Guohua , Ye Miaoting , Wang Jingsheng , Gan Yungen , Zhou Yangyang , Yang Jian , Li Xianjun 
Published: June 2024

BACKGROUND AND OBJECTIVES:
Assessment of postoperative outcomes on pediatric hydrocephalus is critical for adjusting treatment strategies. The aim of this work was to investigate the ability of MRI metrics to predict postoperative outcomes.

METHODS:
A total of 55 children with hydrocephalus who underwent MRI and ventriculoperitoneal shunt surgery were prospectively enrolled. MRI was also performed at 6 months postoperatively in 33 of the 55 children. A total of 92 controls matched for age and sex were enrolled and divided into preoperative and postoperative control groups. We calculated the diffusion tensor imaging along the perivascular space (DTI-ALPS) index, Evans index, and diffusion tensor imaging metrics. The ability of various metrics to predict postoperative outcomes was assessed using receiver operating characteristic curve analysis.

RESULTS:
The DTI-ALPS index was significantly lower in patients with hydrocephalus than in controls. The abnormal DTI-ALPS index trended toward the normal range after surgery. Patients with lower preoperative DTI-ALPS index, lower fractional anisotropy (FA), and higher radial diffusivity in association fibers had less favorable short-term outcomes. Patients with worse long-term outcomes had lower postoperative DTI-ALPS index, higher postoperative Evans index, and lower FA and higher radial diffusivity in association fibers. Predictive performance was better when the DTI-ALPS index and FA in association fibers were used in combination than when either of these metrics was used alone.

CONCLUSION:
The DTI-ALPS index and FA in association fibers provided complementary information for prognostic assessment after the ventriculoperitoneal shunt surgery on pediatric hydrocephalus. A combination of DTI-ALPS index and FA would improve our ability to predict postoperative outcomes in these patients.
Revision of metal-on-metal hip replacements with dual-mobility bearings and acetabular component retention
Authors: Fishley William , Nandra Rajpal , Carluke Ian , Partington Paul F. , Reed Mike R. , Kramer Derek J. , Wilson Matthew J. , Hubble Matthew J. W. , Howell Jonathan R. , Whitehouse Sarah L. , Petheram Timothy G. , Kassam Al-Amin M. 
Published: June 2024

AimsIn metal-on-metal (MoM) hip arthroplasties and resurfacings, mechanically induced corrosion can lead to elevated serum metal ions, a local inflammatory response, and formation of pseudotumours, ultimately requiring revision. The size and diametral clearance of anatomical (ADM) and modular (MDM) dual-mobility polyethylene bearings match those of Birmingham hip MoM components. If the acetabular component is satisfactorily positioned, well integrated into the bone, and has no surface damage, this presents the opportunity for revision with exchange of the metal head for ADM/MDM polyethylene bearings without removal of the acetabular component.MethodsBetween 2012 and 2020, across two centres, 94 patients underwent revision of Birmingham MoM hip arthroplasties or resurfacings. Mean age was 65.5 years (33 to 87). In 53 patients (56.4%), the acetabular component was retained and dual-mobility bearings were used (DM); in 41 (43.6%) the acetabulum was revised (AR). Patients underwent follow-up of minimum two-years (mean 4.6 (2.1 to 8.5) years).ResultsIn the DM group, two (3.8%) patients underwent further surgery: one (1.9%) for dislocation and one (1.9%) for infection. In the AR group, four (9.8%) underwent further procedures: two (4.9%) for loosening of the acetabular component and two (4.9%) following dislocations. There were no other dislocations in either group. In the DM group, operating time (68.4 vs 101.5 mins, p < 0.001), postoperative drop in haemoglobin (16.6 vs 27.8 g/L, p < 0.001), and length of stay (1.8 vs 2.4 days, p < 0.001) were significantly lower. There was a significant reduction in serum metal ions postoperatively in both groups (p < 0.001), although there was no difference between groups for this reduction (p = 0.674 (cobalt); p = 0.186 (chromium)).ConclusionIn selected patients with Birmingham MoM hips, where the acetabular component is well-fixed and in a satisfactory position with no surface damage, the metal head can be exchanged for polyethylene ADM/MDM bearings with retention of the acetabular prosthesis. This presents significant benefits, with a shorter procedure and a lower risk of complications.Cite this article: Bone Jt Open 2024;5(6):514–523.
Trilobatin ameliorates dextran sulfate sodium-induced ulcerative colitis in mice via the NF-κB pathway and alterations in gut microbiota
Authors: Wang Nanbo , Li Zhaohui , Cao Lingling , Cui Zhihua 
Published: June 2024

Objective
This study aimed to evaluate the effects of trilobatin (TLB) on dextran sulfate sodium (DSS)-induced ulcerative colitis (UC) in mice and further explore the underlying mechanisms from the perspectives of signaling pathway and gut microbiota.

Methods
A mouse model of UC was established using DSS. Trilobatin was administered via oral gavage. Disease severity was assessed based on body weight, disease activity index (DAI), colon length, histological detection, inflammation markers, and colonic mucosal barrier damage. Alternations in the NF-κB and PI3K/Akt pathways were detected by marker proteins. High-throughput 16S rRNA sequencing was performed to investigate the gut microbiota of mice.

Results
In the DSS-induced UC mice, TLB (30 μg/g) treatment significantly increased the body weight, reduced the DAI score, alleviated colon length shortening, improved histopathological changes in colon tissue, inhibited the secretion and expression of inflammation factors (TNF-α, IL-1β, and IL-6), and increased the expression of tight-junction proteins (ZO-1 and occludin). Furthermore, TLB (30 μg/g) treatment significantly suppressed the activation of NF-κB pathway and altered the composition and diversity of the gut microbiota, as observed in the variations of the relative abundances of Proteobacteria, Actinobacteriota, and Bacteroidota, in UC mice.

Conclusion
TLB effectively alleviates DSS-induced UC in mice. Regulation of the NF-κB pathway and gut microbiota contributes to TLB-mediated therapeutic effects. Our study not only identified a novel drug candidate for the treatment of UC, but also enhanced our understanding of the biological functions of TLB.
Monoclonal whole IgG impairs both fibrin and thrombin formation: hemostasis and surface plasmon resonance studies
Authors: Gonda Lénárd , Torner Bernadett , Ghansah Harriet , Beke Debreceni Ildikó , Váróczy László , Pénzes-Daku Krisztina , Kappelmayer János 
Published: June 2024

Abstract

Objectives
Monoclonal gammopathies frequently associate with hemostatic alterations. Thrombotic events occur with high incidence particularly upon treatment, while in rarer cases hemorrhagic diathesis can be observed. The pathology of these tendencies could be caused by thrombocytopenia or hyperviscosity burden of circulating monoclonal antibodies. Studies also suggest interference of monoclonal antibodies with primary hemostasis. We isolated monoclonal whole IgG paraproteins from two myeloma patients to observe their effect on thrombin formation and fibrin polymerization.

Methods
Monoclonal whole IgG was prepared from sera of two newly diagnosed untreated multiple myeloma patients and control normal plasma samples. Fibrin formation was measured using thrombin time and dilute prothrombin time tests and thrombin formation was detected with a fluorimetric thrombin generation assay. In addition, molecular interactions were investigated by surface plasmon resonance (SPR).

Results
Thrombin time was prolonged upon addition of monoclonal IgG even at 30 g/L by 12 %, increasing up to 36 % at 60 g/L concentration. Dilute prothrombin time was prolonged by 20 % even at 30 g/L. Thrombin generation assay indicated an impairment in thrombin formation at the presence of monoclonal IgG compared to polyclonal at equivalent concentration. By an SPR assay we determined that both clonality IgG preparations interacted with fibrinogen, however interaction with human thrombin was only detected with monoclonal immunoglobulins (KD=1.03 × 10-7 M).

Conclusions
Here we provide evidence that isolated monoclonal whole IgG from myeloma patients can impair both fibrin and thrombin formation and we demonstrate by SPR assay that it interacts with components of the final phase of the coagulation system.
An interpretable cluster-based logistic regression model, with application to the characterization of response to therapy in severe eosinophilic asthma
Authors: Bilancia Massimo , Nigri Andrea , Cafarelli Barbara , Di Bona Danilo 
Published: June 2024

Abstract
Asthma is a disease characterized by chronic airway hyperresponsiveness and inflammation, with signs of variable airflow limitation and impaired lung function leading to respiratory symptoms such as shortness of breath, chest tightness and cough. Eosinophilic asthma is a distinct phenotype that affects more than half of patients diagnosed with severe asthma. It can be effectively treated with monoclonal antibodies targeting specific immunological signaling pathways that fuel the inflammation underlying the disease, particularly Interleukin-5 (IL-5), a cytokine that plays a crucial role in asthma. In this study, we propose a data analysis pipeline aimed at identifying subphenotypes of severe eosinophilic asthma in relation to response to therapy at follow-up, which could have great potential for use in routine clinical practice. Once an optimal partition of patients into subphenotypes has been determined, the labels indicating the group to which each patient has been assigned are used in a novel way. For each input variable in a specialized logistic regression model, a clusterwise effect on response to therapy is determined by an appropriate interaction term between the input variable under consideration and the cluster label. We show that the clusterwise odds ratios can be meaningfully interpreted conditional on the cluster label. In this way, we can define an effect measure for the response variable for each input variable in each of the groups identified by the clustering algorithm, which is not possible in standard logistic regression because the effect of the reference class is aliased with the overall intercept. The interpretability of the model is enforced by promoting sparsity, a goal achieved by learning interactions in a hierarchical manner using a special group-Lasso technique. In addition, valid expressions are provided for computing odds ratios in the unusual parameterization used by the sparsity-promoting algorithm. We show how to apply the proposed data analysis pipeline to the problem of sub-phenotyping asthma patients also in terms of quality of response to therapy with monoclonal antibodies.
Leader-following consensus tracking control for fractional-order multi-motor systems via disturbance-observer
Authors: Cao Hui , Liu Chuang , Lopes António M. , Gu Panpan , Zhang Youwen 
Published: June 2024

Abstract
The leader-following consensus tracking control of fractional-order (FO) multi-motor systems (FOMMSs) in the presence of exogenous disturbances is investigated. It is widely recognized that FO models are better than integer-order (IO) ones for representing systems with memory effects. Therefore, studying the consensus tracking control of FOMMSs is essential. In this paper, a consensus tracking protocol is developed using a disturbance-observer and state feedback to deal with unknown exogenous disturbances. The closed-loop system stability is analyzed via Lyapunov and graph theory. Novel sufficient conditions for the stabilization of each motor are derived in the form of linear matrix inequalities. Simulation results illustrate the validity and efficacy of the proposed consensus protocol, namely its strong synchronization ability and robustness.
(Dy)fuzje
Authors: Kmiecik Michalina , Wójtowicz Aleksander , Śniecikowska Beata , Staroń Justyna , Niewiadomski Andrzej , Śliwa Anna , Bocheński Tomasz , Stangret Paweł , Rejniak-Majewska Agnieszka , Pachocki Dariusz , Załuski Tomasz , Muzyczuk Daniel 
Published: June 2024

Publikacja jest efektem projektu realizowanego w Muzeum Sztuki w Łodzi w kooperacji z Zakładem Literatury XX i XXI wieku UŁ. Badania, prowadzone w duchu case studies, koncentrowały się na zjawiskach świadczących o przywiązaniu artystów do rozmaitych wariantów awangardowo pojętej zasady integracji sztuk. Akcentowały one także zbieżność dążeń twórców w Polsce po 1945 roku w różnych kontekstach społeczno-politycznych, instytucjonalnych czy nawet towarzyskich.
Książka dotyczy sojuszy i analogii w obrębie sztuk wizualnych i literatury – zarówno ponad ich zwyczajowo respektowanymi formułami, jak i w umownie przestrzeganych i honorowanych granicach. Autorzy zgromadzonych tekstów starają się uchwycić wzajemne artystyczne stymulowanie w rozprzestrzenianiu konkretnych idei, a zarazem interesuje ich zmiana usytuowań i optyk w postrzeganiu pozornie dobrze znanych zagadnień; innymi słowy – wszystko to, co kryje się w semantycznym potencjale tytułowych „(dy)fuzji”.
„Tom ma wyraźny rys nowatorski – i to zarówno w płaszczyźnie rewelatorskiej (tam, gdzie mowa jest o zjawiskach słabo zbadanych), jak i w obszarze repetycji (tam, gdzie poruszane są zagadnienia nie najgorzej opracowane). […] Wyłania się też w nim pewien dział by tak rzec, poznawczy. Po jednej jego stronie sytuują się przyczynki do twórczości bardzo znanych i znanych artystów (Białoszewski, Brzozowski, Buczkowski, Czycz, Haupt, Kantor, Peiper, Strzemiński, Themerson), z drugiej natomiast strony otrzymujemy kompetentne teksty, poświęcone artystom i zjawiskom znanym mniej lub niemal wcale (Bruszewski, Dłużniewski, Kryszkowski, Partum czy też sztuka artzinów). Siłą rzeczy, te pierwsze przyczynki wymagają podjęcia swoistego agonu z badaczami-poprzednikami, te drugie zaś stanowią nowość intelektualną niejako same przez się. Takie zestawienie wydaje się bardzo ożywcze dla wymowy całej publikacji”.
Z recenzji dr. hab. Piotra Łuszczykiewicza, prof. UAM
Quantitative vs. Qualitative Outcomes: A Longitudinal Study of Risk and Ambiguity in Monetary and Medical Decision-Making
Authors: Xu Chelsea Y. , Dan Ohad , Jia Ruonan , Wertheimer Emily , Chawla Megha , Fuhrmann-Alpert Galit , Fried Terri , Levy Ifat 
Published: June 2024

Abstract

How do decision-makers choose between alternatives offering outcomes that are not easily quantifiable? Previous literature on decisions under uncertainty focused on alternatives with quantifiable outcomes, for example monetary lotteries. In such scenarios, decision-makers make decisions based on success chance, outcome magnitude, and individual preferences for uncertainty. It is not clear, however, how individuals construct subjective values when outcomes are not directly quantifiable. To explore how decision-makers choose when facing non-quantifiable outcomes, we focus here on medical decisions with qualitative outcomes. Specifically, we ask whether decision-makers exhibit the same attitudes towards two types of uncertainty - risk and ambiguity - across domains with quantitative and qualitative outcomes. To answer this question, we designed an online decision-making task where participants made binary choices between alternatives offering either guaranteed lower outcomes or potentially higher outcomes that are associated with some risk and ambiguity. The outcomes of choices were either different magnitudes of monetary gains or levels of improvement in a medical condition. We recruited 429 online participants and repeated the survey in two waves, which allowed us to compare the between-domain attitude consistency with within-domain consistency, over time. We found that risk and ambiguity attitudes were moderately correlated across domains. Over time, risk attitudes had slightly higher correlations compared to across domains, while in ambiguity over-time correlations were slightly weaker. These findings are consistent with the conceptualization of risk attitude as more trait-like, and ambiguity attitudes as more state-like. We discuss the implications and applicability of our novel modeling approach to broader contexts with non-quantifiable outcomes.
Enhancing the Tracking Performance of Wind Turbine Blade Pitch Angle Control via Model-Free Adaptive Control Algorithm Utilizing Input-Output Differential
Authors: Zhou Ziang , Wang Shuangxin , Jiang Jiading , Li Hongrui , Zhao Juchao , Yu Dingli , li yaguang 
Published: June 2024

Abstract

In the context of wind energy systems, maintaining optimal power output in wind turbines when wind speeds exceed rated values necessitates precise regulation of blade pitch through the pitch control system. However, challenges in accurately modeling nonlinear control systems and enhancing control responsiveness arise due to factors such as actuator constraints, unmodeled dynamics, and random wind speed fluctuations. This paper proposes an improved model-free control, termed Input-Output Model-Free Adaptive Control (IO-MFAC). It enhances the system's adaptability to stochastic wind and improves tracking capabilities by adaptively adjusting the input difference based on the output difference through the new cost function. Moreover, to demonstrate the stability of IO-MFAC, its monotonic convergence is theoretically confirmed. Simulations conducted on the FAST simulator and hardware-in-the-loop experiments demonstrate that IO-MFAC outperforms basic MFAC under constant wind and turbulent conditions, exhibiting superior dynamic tracking performance, control effectiveness, and practical utility.
Cancer Cachexia-related Monocytic MDSCs Impair T-cell Negative Selection and Predict Immune-related Adverse Events
Authors: Li Xing , Wei Li , Huang Run-Kai , Ren Jian-Hua , Huang Ze-Xuan , Zhang Yuan , Pang Xiu-Qing , Lv Xiao-tong , Wu Xiangyuan , Xing Yan-Fang 
Published: June 2024

Abstract

Background
Cancer cachexia is prevalent in multiple cancers and is associated with chemotherapy toxicity. However, data on the relationship between immune-related adverse events (irAEs) and cachexia are limited.
Methods
A murine model of orthotopic hepatocellular carcinoma (HCC) with cachexia was constructed to determine the effect of T-cell infiltration in multiple tumor-free organs on irAEs occurrence. Single-cell sequencing of thymic stromal cells was conducted. Patients with advanced cancers receiving anti-PD-1/L1 antibody treatment were followed up to investigate the relationship between cachexia and irAEs.
Results
Inflammatory cells infiltrated multiple tumor-free organs in cachexic HCC but not in non-cachexic mice. Immunofluorescence revealed that these infiltrating cells included CD4+ and CD8+ T-cells. Morphological assessment and hematoxylin-eosin staining confirmed thymus atrophy in cachexic HCC mice. Single-cell sequencing of thymic stromal cells showed fewer medullary thymic epithelial cells (mTECs) II and III in the thymus of cachexic mice than in those of non-cachexic mice. Aire downregulation was accompanied by decreased expression of tissue-restricted antigens in mTECs. T cells from cachexic HCC mice induced inflammation and T cell infiltration in multiple organs of tumor-free mice in an organ-specific manner. After administration of anti-mouse PD-1 antibody, the incidence of inflammation in multiple organs was much higher in cachexic HCC mice as well as tumor free mice transferred with T cells from cachexic HCC mice. Thymic monocytic myeloid-derived suppressor cells (M-MDSCs) enriched in cachexic HCC mice, evidenced by flow cytometer and immunofluorescence analyses. M-MDSCs infiltrated the thymus in cachexic mice with cancer. Cachexia-related M-MDSCs induced mTEC from tumor-free mice apoptosis through nitric oxide production in vitro. M-MDSCs transfer induced infiltration of inflammatory cells in multiple organs and thymus involution of tumor free mice without decreasing their weights. Sixty-four patients with advanced cancer receiving anti-PD-1/L1 antibody treatment were included in this study. Patients with irAEs displayed higher levels of circulating M-MDSCs than those without irAEs. Moreover, patients with cachexia (BMI < 20 kg/m2 or weight loss ≥ 5% over the past 6 months) had higher M-MDSC levels. Patients with high M-MDSC levels and low BMI or weight loss ≥ 5% experienced more irAEs (HR 2.333, 95% CI 1.231–4.423).
Conclusions
M-MDSCs induced mTEC apoptosis through nitric oxide production in cachexic mice with cancer, impairing T-cell negative selection and leading to autoimmune T-cell infiltration in tumor-free organs. Cancer cachexia-related M-MDSCs are potential predictive biomarkers of irAEs in patients with advanced cancer.