bluuebunny/crossref_metadata_2025_split huggingface dataset:
ChemInform Abstract: Synthesis of 2‐Aminofurans and 2‐Unsubstituted Furans via Carbenoid‐Mediated [3 + 2] Cycloaddition.
Authors: Jiang Yaojia , Khong Vanessa Zhong Yue , Lourdusamy Emmanuvel , Park Cheol‐Min 
Published: July 2012

AbstractThe cycloaddition of diazo compounds (I) with enamines (II) followed by oxidation of intermediate 2‐amino‐2,3‐dihydrofurans leads to 2‐aminofurans (III), whilst the treatment of intermediates with TosOH gives rise to 2‐unsubstituted furans (IV).
ChemInform Abstract: Direct Carboxylation of Thiophenes and Benzothiophenes with the Aid of EtAlCl2.
Authors: Nemoto Koji , Onozawa Satoru , Konno Megumi , Morohashi Naoya , Hattori Tetsutaro 
Published: July 2012

AbstractThe Lewis acid mediated carboxylation of thiophenes and benzothiophenes bearing alkyl or aryl substituents at the 2‐ or 3‐positions affords the corresponding 2‐ or 3‐carboxylic acids in up to 90% yield.
ChemInform Abstract: An Efficient Synthesis of 3,3‐Difluoro‐pyrrolidine Hydrochloride Starting with 2‐Chloro‐2,2‐difluoroacetic Acid.
Authors: Wei Lulin , Makowski Teresa M. , Rutherford Jennifer L. 
Published: July 2012

AbstractA fluorination‐free synthesis of title compound (IV) is presented.
ChemInform Abstract: Asymmetric Synthesis of Allenyl Oxindoles and Spirooxindoles by a Catalytic Enantioselective Saucy—Marbet Claisen Rearrangement.
Authors: Cao Trung , Deitch Joshua , Linton Elizabeth C. , Kozlowski Marisa C. 
Published: July 2012

AbstractThe rearrangement of alkynyl substrates allows the synthesis of allenyl oxindoles having a quarternary stereocenters.
ChemInform Abstract: Catalytic System for Inhibition of Amination‐Type Reaction and Palladium‐Catalyzed Direct Arylation Using Non‐Protected Pyrazole Derivatives.
Authors: Derridj Fazia , Roger Julien , Djebbar Safia , Doucet Henri 
Published: July 2012

Abstract5‐Aminopyrazoles (I) and (IV) are arylated at the 4‐position by aryl bromides in the presence of KOAc.
ChemInform Abstract: Enantioselective Synthesis of β‐Pyrazole‐Substituted Alcohols Through an Asymmetric Ring‐Opening Reaction of meso‐Epoxides.
Authors: Hu Xiaolei , Gao Bo , Chu Yangyang , Li Wei , Liu Xiaohua , Lin Lili , Feng Xiaoming 
Published: July 2012

AbstractIn the presence of an optimized N,N′‐dioxide—Sc(OTf)3 catalyst, a variety of pyrazoles and meso‐epoxides are transformed to the title syn‐β‐pyrazolyl‐substituted alcohols with up to 99% enantioselectivity.
ChemInform Abstract: Application of [3 + 2]‐Cycloaddition in the Synthesis of Valdecoxib.
Authors: Reddy Anumula Raghupathi , Goverdhan Gilla , Sampath Aalla , Mukkanti Khagga , Reddy Padi Pratap , Bandichhor Rakeshwar 
Published: July 2012

AbstractAll products are purified by either simple filtration or recrystallization.
ChemInform Abstract: Synthesis of Bis‐Heterocyclic 1H‐Imidazole 3‐Oxides from 3‐Oxido‐1H‐imidazole‐4‐carbohydrazides.
Authors: Pieczonka Adam Marek , Mloston Grzegorz , Heimgartner Heinz 
Published: July 2012

AbstractThe cyclization of thiosemicarbazides (III) and semicarbazides (VIII) in a diluted NaOH solution leads to corresponding triazole derivatives (IV) and (IX), whilst the cyclization of compounds (III) in concentrated sulfuric acid affords thiadiazolamines (VI).
ChemInform Abstract: Facile One‐Pot Synthesis of Monosubstituted 1‐Aryl‐1H‐1,2,3‐triazoles from Arylboronic Acids and Prop‐2‐ynoic Acid (= Propiolic Acid) or Calcium Acetylide (= Calcium Carbide) as Acetylene Source.
Authors: Yang Qing , Jiang Yubo , Kuang Chunxiang 
Published: July 2012

AbstractA convenient one‐pot procedure is elaborated for the conversion of arylboronic acids (I) into 1‐aryl‐1H‐1,2,3‐triazoles.
ChemInform Abstract: A Facile Synthesis of Novel Spiro Indoline‐Based Heterocycles Through 1,3‐Dipolar Cycloaddition Reactions
Authors: Souzangarzadeh Saeid , Bazian Atiye , Anaraki‐Ardakani Hossein 
Published: July 2012

Abstractof isatin imines (I) and nitrilimines under classical or microwave irradiation conditions
ChemInform Abstract: Tandem Reaction of 3‐Hydroxyhexa‐4,5‐allenic Esters: A Novel Access to Diversely Substituted 2H‐Pyran‐2‐ones and Indenes.
Authors: Xu Haiyun , Zhang Xinying , He Yan , Guo Shenghai , Fan Xuesen 
Published: July 2012

AbstractA novel method is elaborated for the preparation of substituted pyran‐2‐ones (II) by H2SO4‐catalyzed domino reaction of esters (I).
ChemInform Abstract: Using Water, Light, Air and Spirulina to Access a Wide Variety of Polyoxygenated Compounds.
Authors: Noutsias Dimitris , Alexopoulou Ioanna , Montagnon Tamsyn , Vassilikogiannakis Georgios 
Published: July 2012

AbstractThe photooxygenation of furan substrates in the presence of Spirulina as a source of photosensitizers in water provides access to a diverse range of synthetically useful polyoxygenated motifs commonly found in various natural products.
ChemInform Abstract: H4SiW12O40: An Efficient Catalyst for the Synthesis of New Spiro‐[dibenzo[a,i]xanthene‐14,3′‐indoline]‐2′,8,13‐triones.
Authors: Yang Li Min , Yin Zhi Kui , Wu Li Qiang 
Published: July 2012

AbstractA simple one‐pot method is developed for the synthesis of the title compounds via three‐component reaction.
ChemInform Abstract: Nano N‐TiO2 Mediated Selective Photocatalytic Synthesis of Quinaldines from Nitrobenzenes.
Authors: Selvam Kaliyamoorthy , Swaminathan Meenakshisundaram 
Published: July 2012

AbstractN‐Doped titanium dioxide is successfully applied as catalyst in the photo‐induced reaction of nitrobenzenes (I) with ethanol to give quinaldine derivatives (III).
ChemInform Abstract: 2‐(N‐Allylaminomethyl)cinnamaldehydes as Substrates for Syntheses of Azapolycycles via Intramolecular Cycloaddition Reactions.
Authors: Mishra Amita , Rastogi Neeraj , Batra Sanjay 
Published: July 2012

AbstractThe title substrates (I) and (VI), which are derived from Morita‐Baylis‐Hillman adducts, are employed for the synthesis of aza‐polycycles for the first time.
ChemInform Abstract: Facile One‐Pot Synthesis of Pyrido[2,3‐d]pyrimidine Derivatives over ZrO2 Nanoparticles Catalyst.
Authors: Abdolmohammadi Shahrzad , Afsharpour Maryam 
Published: July 2012

AbstractTandem Knoevenagel—Michael addition of aromatic aldehydes, methylcyanoacetate, and aminouracil proceeds under neat conditions.
ChemInform Abstract: Synthesis of Thieno[2,3‐d]pyrimidines, Thieno[2,3‐d]triazinones and Thieno[2,3‐e]diazepinones of Anticipated Anticancer Activity.
Authors: Kandeel M. M. , Mounir Ashraf A. , Refaat Hanan M. , Kassab Asmaa E. 
Published: July 2012

AbstractA variety of hitherto unknown title heterocycles fused to cyclooctane is synthesized and evaluated for their anticancer activities.
ChemInform Abstract: Isocyanide‐Based Five‐Component Synthesis of 2‐Aryl‐2‐(2,3,4,5‐tetrahydro‐2,4‐dioxo‐1H‐1,5‐benzodiazepin‐3‐yl) acetamides (= α‐Aryl‐2,3,4,5‐tetrahydro‐2,4‐dioxo‐1H‐1,5‐benzodiazepine‐3‐acetam ides).
Authors: Akbarzadeh Roya , Amanpour Tayebeh , Soorki Ali Abolhasani , Bazgir Ayoob 
Published: July 2012

AbstractSome of the novel benzodiazepine derivatives show good antibacterial and/or antifungal activities.
ChemInform Abstract: Stereoselective Synthesis of 6‐Oxabicyclo[3.2.1]octene via (3,5)‐Oxonium‐ene Reaction.
Authors: Saha Pipas , Saikia Anil K. 
Published: July 2012

AbstractFor the first time an efficient synthesis of the title compounds from readily available naturally occurring terpenoid is reported.
ChemInform Abstract: Utilization of the Hydroxyalkylation Reaction to Prepare Bis(benzocrown Ethers).
Authors: Zielinski Matthew E. , Tracy Adam F. , Klumpp Douglas A. 
Published: July 2012

AbstractA simple protocol is presented for the acid‐mediated condensation of isatins (I), ninhydrin (IV) or 2‐pyridinecarboxaldehyde with benzocrown ethers.
ChemInform Abstract: Exploiting the Use of Ionic Liquids to Access Phosphorodiamidites.
Authors: Crossey Kerri , Hardacre Christopher , Migaud Marie E. , Norman Sarah E. 
Published: July 2012

AbstractHighly moisture‐sensitive phosphorodiamidites (III) and (V) are selectively formed by reaction of alkoxydichlorophosphine with secondary amines in ionic liquids as reaction medium.
ChemInform Abstract: Synthesis and Reactivity of Alkoxy(trimethylsiloxy)phosphines and Their Derivatives.
Authors: Prishchenko Andrey A. , Livantsov Mikhail V. , Novikova Olga P. , Livantsova Ludmila I. , Petrosyan Valery S. 
Published: July 2012

AbstractAlkoxy(trimethylsiloxy)phosphines like (IV) are obtained by reaction of alkyl hypophosphites, prepared in situ, with N‐trimethylsilylsuccinimide (III).
ChemInform Abstract: Zn(OAc)2·2H2O‐Catalyzed Synthesis of α‐Aminophosphonates under Neat Reaction.
Authors: Arigala Uma Ravi Sankar , Matcha Chaitanya , Yoon Kuk Ro 
Published: July 2012

AbstractA series of new α‐aminophosphonates (IV) (12 examples) is synthesized via a Zn‐catalyzed multicomponent reaction.
ChemInform Abstract: Synthesis of Pyrazolo[1,3,2]diazaphosphinin‐4‐ones.
Authors: Marchenko Anatoliy P. , Koidan Georgiy N. , Huryeva Anastasiya S. , Smaliy Radomyr V. , Yurchenko Aleksandr A. , Kostyk Aleksandr N. 
Published: July 2012

AbstractPhosphinimidic isocyanates (V), (VIII) and (X) derived from the corresponding 3‐ ,4‐ , and 5‐aminopyrazoles [cf.
ChemInform Abstract: Role of Temperature in [3 + 2]‐Cycloaddition of Isoselenocyanates with Oxiranes Using BF3·Et2O.
Authors: Sengoden Mani , Punniyamurthy Tharmalingam 
Published: July 2012

AbstractBF3·OEt2‐Catalyzed cycloaddition of various epoxides with isoselenocyanates provides access towards iminooxaselenolanes, e.g. (III) and (VIII), or oxazolidinones, e.g. (IV) and (IX), at ‐5 °C or +40 °C, respectively.
ChemInform Abstract: Tigliane Diterpene Esters with IFN γ‐Inducing Activity from the Leaves of Aleurites fordii.
Authors: Pei Yi‐Hua , Kim Jae Wha , Kang Ho‐Bum , Lee Hyeong‐Kyu , Kim Chan‐Soo , Song Hyuk‐Hwan , Chin Young‐Won , Oh Sei‐Ryang 
Published: July 2012

AbstractBioactivity‐guided fractionation of the leaves of aleurites fordii leads to the isolation of the new phorbol ester (I) together with four known phorbol esters.
ChemInform Abstract: Effective Asymmetric Synthesis of the Key Chiral Building Blocks of 20(S)‐ and 20(R)‐Camptothecins.
Authors: Yu Sanbao , Feng Xiangjun , Luo Yu , Lu Wei 
Published: July 2012

AbstractThe key chiral building blocks (IXa) and (IXb) as well as their (R)‐enantiomers are synthesized via an asymmetric bromolactonization to give (II), an epoxydation of β‐bromohydroxycarboxylate (V) and their ring‐opening reactions.
ChemInform Abstract: Novel Hybrid Molecules Based on 15‐Membered Azalide as Potential Antimalarial Agents.
Authors: Starcevic Kristina , Pesic Dijana , Toplak Ana , Landek Goran , Alihodzic Sulejman , Herreros Esperanza , Ferrer Santiago , Spaventi Radan , Peric Mihaela 
Published: July 2012

AbstractNovel hybrid molecules comprising 4‐aminoquinoline moiety covalently linked to 15‐membered azalide scaffold at position C‐3′ are synthesized and biologically evaluated.
A generalized Fleming and Harrington's class of tests for interval‐censored data
Authors: Oller Ramon , Gómez Guadalupe 
Published: July 2012

AbstractThe class$G^{\rho,\lambda }$of weighted log‐rank tests proposed by Fleming & Harrington [Fleming & Harrington (1991)Counting Processes and Survival Analysis, Wiley, New York] has been widely used in survival analysis and is nowadays, unquestionably, the established method to compare, nonparametrically,kdifferent survival functions based on right‐censored survival data. This paper extends the$G^{\rho,\lambda }$class to interval‐censored data. First we introduce a new general class of rank based tests, then we show the analogy to the above proposal of Fleming & Harrington. The asymptotic behaviour of the proposed tests is derived using an observed Fisher information approach and a permutation approach. Aiming to make this family of tests interpretable and useful for practitioners, we explain how to interpret different choices of weights and we apply it to data from a cohort of intravenous drug users at risk for HIV infection.The Canadian Journal of Statistics40: 501–516; 2012 © 2012 Statistical Society of Canada
Product Evaluation for the Control of Chemical Emissions to Indoor Air – 10 Years of Experience with the AgBB Scheme in Germany
Authors: Däumling Christine 
Published: July 2012

AbstractEmissions from construction products may have a significant impact on the quality of indoor air, particularly in energy‐efficient buildings, where the normal rate of air exchange with fresh ambient air may be limited. In this context, reduction strategies to mitigate the concentration of chemicals in the indoor environment have become even more important. German authorities wanted to foster the development of low‐emission products, and as a result it was necessary to quantify and qualify these emissions in a reliable and objective manner. The core principles for evaluation of the standardized measurements in emission tests were established by the “Committee for Health‐Related Evaluation of Building Products” (AgBB) and published in the so‐called “AgBB scheme”. Relevant for evaluation are: (i) Assessment of the emission levels of substances with known toxicological properties; (ii) limits for non‐assessable or unknown substances; (iii) limits for the total amount of chemical emissions. This review describes the stepwise implementation of the test procedure in Germany and the experience gained in evaluation of product emissions over the years. A comprehensive overview of the philosophy, history, current practices, and future directions of the German AgBB scheme for VOC emissions is also provided. Special emphasis is given to the evaluation of a list of about 170 single substances which have an agreed “lowest concentration of interest” (LCI) value for the indoor environment – values that are updated periodically according to present toxicological knowledge.
Ozone Weekend Effect Analysis in Three European Urban Areas
Authors: Pires José Carlos M. 
Published: July 2012

AbstractThis paper aims to apply statistical procedures to analyse the ozone weekend effect (OWE) in three European urban areas: Lisbon, Oporto and London. Seasonal variations of surface ozone (O3) and total oxidant species (Ox) concentrations are presented. The studied period was from January 2007 to December 2009. The O3 annual average profile in London was significantly different from the ones achieved for Lisbon and Oporto, due to the high emissions of nitrogen oxides and low temperatures (associated with low solar radiations). The influence of nitrogen oxides in atmospheric chemistry of London was analysed by linear correlations between O3 concentrations and NO2/NO ratio. High values during almost all period showed that O3 concentrations are mainly influenced by NONO2O3 chemical reaction. On the other hand, the linear correlations between O3 and NO2 concentrations only presented positive values in Lisbon and Oporto. This behaviour is associated with photo‐dissociation of NO2, producing O3 during the spring and summer periods. Additionally, cluster analysis was applied to group the days of week according the correspondent O3 behaviour. The weekend and some weekdays (immediately after or before) were grouped in the same cluster, showing that OWE occurs in all urban areas selected in this study. These findings suggest that the applied statistical procedures should be used to analyse the OWE and that the causes for the different O3 behaviours during the week may be influenced by meteorological variables.
Excision repair cross‐complementing gene‐1, ribonucleotide reductase subunit M1, ribonucleotide reductase subunit M2, and human equilibrative nucleoside transporter‐1 expression and prognostic value in biliary tract malignancy
Authors: Fisher Sarah B. , Fisher Kevin E. , Patel Sameer H. , Lim Matthew G. , Kooby David A. , El‐Rayes Bassel F. , Staley Charles A. , Adsay N. Volkan , Farris Alton B. , Maithel Shishir K. 
Published: July 2012

AbstractBACKGROUND:Tumor expression of excision cross‐complementing gene‐1 (ERCC1), human equilibrative nucleoside transporter 1 (hENT1), ribonucleotide reductase subunit M1 (RRM1), and ribonucleotide reductase subunit M2 (RRM2), is associated with the efficacy of platinum and gemcitabine chemotherapy. The authors of this report recently demonstrated that high ERCC1 and RRM2 expression levels are independent negative prognostic markers for survival in early stage pancreas cancer. The differential expression and prognostic value of these biomarkers in biliary tract malignancy (BTM) is unknown.METHODS:In total, 63 patients who had tissue available for analysis were selected from a prospective database of all patients (n = 104) who underwent resection of BTM (intrahepatic, hilar, or distal cholangiocarcinoma; gallbladder carcinoma) between January 2000 and December 2008. Immunohistochemistry for ERCC1, hENT1, RRM1, and RRM2 expression was performed. Staining was scored by a single pathologist who was blinded to patient outcomes.RESULTS:The median patient age was 67 years. The median overall survival (OS) was 16.2 months, and the median follow‐up was 32.7 months. Only 3 BTMs (4.8%) had high ERCC1 expression, and 92.1% and 81% of BTMs exhibited high hENT1 and RRM1 expression, respectively. RRM2 expression varied, and 32% of tumors demonstrated high RRM2 expression. ERCC1 and RRM1 were not associated with OS. High RRM2 expression was associated with a trend toward improved OS (30.8 months vs 16.2 months; P = .06), and high hENT1 expression was associated with improved OS (17.7 months vs 9.5 months; P = .04).CONCLUSIONS:Most BTMs exhibited low ERCC1 expression and high hENT1 and RRM1 expression, whereas RRM2 expression levels varied. High expression of hENT1 was associated with improved OS. These findings may have implications for the selection of chemotherapy agents (gemcitabine vs platinum) and the stratification of patients in chemotherapy trials that assess outcome. Cancer 2013. © 2012 American Cancer Society.
Strongly Reduced Si Surface Recombination by Charge Injection during Etching in Diluted HF/HNO3
Authors: Greil Stefanie M. , Schöpke Andreas , Rappich Jörg 
Published: July 2012

AbstractHerein, we investigate the behaviour of the surface recombination of light‐induced charge carriers during the etching of Si in alkaline (KOH) and acidic etching solutions of HF/HNO3/CH3COOH (HNA) or HF/HNO3/H3PO4 (HNP) at different concentration ratios of HF and HNO3 by means of photoluminescence (PL) measurements. The surface recombination velocity is strongly reduced during the first stages of etching in HF/HNO3‐containing solutions pointing to a interface well passivated by the etching process, where a positive surface charge is induced by hole injection from NO‐related surface species into the Si near‐surface region (back surface field effect). This injected charge leads to a change in band bending by about 150 mV that repulses the light‐induced charge carriers from the surface and therefore enhances the photoluminescence intensity, since non‐radiative surface recombination is reduced.
Color in Poly(3,4‐ethylenedioxythiophene) with Profound Implications for Electronic, Electrochemical, and Optical Functions
Authors: Sydam Rambabu , Deepa Melepurath 
Published: July 2012

AbstractPoly(3,4‐ethylenedioxythiophene) (PEDOT) films have been synthesized by a facile electropolymerization route by using poly(diallyldimethylammonium) chloride (PDDA) as the counter‐ion source. To enhance their efficacy, the fullerene derivative N‐methyl fulleropyrrolidine (N‐FP) was embedded in the PEDOT/PDDA films; the electron‐conducting ability of the N‐FP came to the fore, as the conductivity, optical contrast, and ion‐storage capacity were greater in the PEDOT/PDDA/N‐FP film than in the PEDOT/PDDA film. Both the PEDOT/PDDA and PEDOT/PDDA/N‐FP films showed an unprecedented dramatic digression from the expected optical response of conventional PEDOT, exhibiting distinct π–π* absorptions in the visible region in air, corresponding to a bandgap of 1.1–1.3 eV, which is outside the established range (1.6–1.7 eV). The neutral state of these films showed split components, which was simultaneously accompanied by a reversible color change from bright blue (in oxidized form) to deep brown (in reduced form). This is a most unusual color transition for PEDOT, as it opposes the well‐established colors that vacillate between dark blue (reduced) and sky blue (oxidized) tones. Atomic force microscopy and Kelvin probe force microscopy provided evidence for the higher nanoscale current‐carrying capacity and lower localized work function for PEDOT/PDDA/N‐FP than for PEDOT/PDDA; both the energetics and conductivity are conducive for fast redox switching. The serendipitous but easily reproducible synthesis method and results for PEDOT/PDDA and PEDOT/PDDA/N‐FP pave the way for the utilization of this material for electronic, electrochemical, and optical functions. This is different from what is currently known about the molecular‐level feature control of macroscopic properties.
Institutional Investment and Corporate Social Performance: Linkage towards Sustainable Development
Authors: Ahmed Sarwar Uddin , Islam Zahidul , Mahtab Hanif , Hasan Ikramul 
Published: July 2012

ABSTRACTThis study examines the relationship between institutional investment (II) and corporate social performance (CSP) of public listed companies (PLCs) in Bangladesh using cross‐sectional data. The sample includes 152 firms as listed in Dhaka Stock Exchange (DSE). Structured questionnaires, annual reports, CSR reports, websites, regulatory notifications, and newspaper articles were used for data collection.The results of the study indicate that CSP has a positive but insignificant relationship with institutional investment in Bangladesh. This would also improve the investment climate by encouraging the institutional investors to make their investment decisions based on long‐term sustainability. To the best of our knowledge, the paper investigates, for the first time, the linkage between institutional investment and CSP in the context of a developing country like Bangladesh. In the process, this paper attempts to develop the first known comprehensive CSP Index in the context of Bangladesh. Copyright © 2012 John Wiley & Sons, Ltd and ERP Environment
Continuous D‐Fructose Dehydration to 5‐ Hydroxymethylfurfural Under Mild Conditions
Authors: Aellig Christof , Hermans Ive 
Published: July 2012

AbstractThe dehydration of D‐fructose to 5‐hydroxymethylfurfural was studied under single‐phase conditions in the low boiling solvent 1,4‐dioxane at moderate temperatures in the presence of the solid acid‐catalyst Amberlyst‐15. The reaction was first examined and optimized under batch conditions, where it was found that the yield could be increased up to 75 % by adding small amounts of DMSO. Subsequently, the reaction was performed under continuous flow in a fixed bed reactor. Internal and external mass transfer limitations could be eliminated by changing the particle size and by adjusting the flow rate. Under continuous conditions, the HMF yield could be further increased to 92 %; the space–time yield was found to be 75 times higher compared to the batch case. A long‐term stability test (96 h), including solvent regeneration, demonstrated that the catalyst is stable over time. Additionally, it was shown that even small amounts of water have a negative effect on the HMF yield. Overall, the present system shows a good alternative to other systems presented in literature because high space–time yields and selectivities were obtained under relatively mild and continuous conditions.