bluuebunny/crossref_metadata_2025_split huggingface dataset:
Correlation between age, the clinical status of patients, operator characteristics, and surgical landmarks with the incidence of tracheotomy complications
Authors: Anindito Evan , Yusuf Muhtarum , Ahadiah Titiek H 
Published: May 2024

Link of Video Abstract: https://www.youtube.com/watch?v=YTXRefXDzlU

Background: Tracheotomy is a surgical procedure often performed in the field of ear, nose, throat-head, and neck surgery. This study aims to analyze the risk factors for tracheotomy complications based on age, clinical status, operator characteristics and surgical landmarks.
Methods: This study was analytically observational with a case-control design using secondary data. The study was conducted at Dr. Soetomo Hospital Surabaya. Patients who had a tracheotomy for the period January 1, 2015 to December 31, 2019 and met the research criteria were included as samples.
Results: This study obtained 174 patients with 136 men and 38 women. Analysis of the correlation between age and the incidence of tracheotomy complications obtained p=0.008 (p<0.05). The correlation between clinical status of patients with complications of tracheotomy was found to be significant (p=0.001). The correlation between operator characteristics and tracheotomy complications was significant (p=0.000) and the correlation between surgical landmarks and tracheotomy complications was significant (p= 0.000).
Conclusion: The correlation between age, the patient's clinical status, operator characteristics and surgical landmarks with the incidence of tracheotomy complications from 174 patients who underwent tracheotomy surgery at Dr. Soetomo Hospital Surabaya showed that these factors mutually influence the postoperative complications of tracheotomy.
Medication adherence and visiting compliance: interventions self-management education based on health belief model
Authors: Joni Iskandar  , Setiyowati Eppy , Chilyatis Zahroh  
Published: May 2024

Introduction: The large number of TB cases was caused by the boredom of treatment for too long, the lack of knowledge of patients about pulmonary TB, the distance between the patient's home and public health services. The purpose was to analyze effect interventions of self-management education based on the health belief model on adherence medications and visiting compliance in pulmonary tuberculosis patients at Community health center Pamekasan Regency.
Method: This research is conducted using a quantitative approach, type of intervention research. Participants in this study were the >20 year old age group. This study has certain characteristics on the selection of subjects; therefore use purposive sampling techniques. Intervention Researchers gave treatment self-management education based on a health belief model. The collected data is then analyzed using a statistical test independent T-test with the level of significance α = 0,05.
Result: The average difference in drug administration adherence in the intervention group was 17.89 with a standard deviation of 9,650. The control group showed a difference in drug adherence value of 5.23 and a standard deviation of 3,456. The average difference in visiting compliance in the intervention group was 15.37 with a standard deviation of 6,130. In the control group it showed a visiting compliance difference value of 5.76 and a standard deviation of 4,162.
Conclusion: There was an influence of self-management education based on health belief model on increasing adherence to taking medications and increasing visiting compliance in tuberculosis patients at community health centers in Pamekasan Regency, East Java, Indonesia
Effect of COVID-19 pandemic large-scale social restriction to low back pain epidemiology, a single center study in Jakarta, Indonesia
Authors: Winaga Handriadi , Irfan Ario Stevanus , Gunawan Vincent , Andikusuma Samuel , Kennedy Dave 
Published: May 2024

Link of Video Abstract: https://youtu.be/oyaEnUqaE9k

Background: With the increase in COVID-19 cases, Indonesia’s government enforced the Large-Scale Social Restriction (LSSR) that started on April 1st, 2020. Despite LSSR’s ability to decrease COVID-19 transmissions, LSSR also leads to an increase in depression disorder, change in dietary habits and lower physical activity, which are factors that affect low back pain (LBP) incidence. The objective of this study is to evaluate the incidence of LBP during LSSR in the COVID-19 pandemic, especially in Atma Jaya Hospital, Jakarta.
Methods: This study is a descriptive-analytic research. The data was taken from the medical records of patients whose ages are>18 years old and who complained of LBP symptoms. We divide our data into Pre- (July–December 2019) and during LSSR (July–December 2020). Statistical analysis is significant if α<0.05. Missing data will be excluded.
Results: Total orthopedics patients in Atma Jaya Hospital, Jakarta, in pre-and during LSSR were 1405 and 837, respectively. Only around 269 and 178 patients, respectively, had LBP complaints. There is a decrease of 5.2% in traumatic LBP complaints during LSSR compared with pre-LSSR (p=0.13). We found significant differences in number of subjects with HNP (20.1% vs 12.4%, p=0.034) and scoliosis (2.6% vs 8.4%, p=0.005). Pharmacological and physiotherapy were the mainstays of treatment for LBP complaints, with no significant difference in the number of patients who received them.
Conclusion: The LSSR does not significantly affect the number of LBP patients in an orthopedic clinic at Atma Jaya Hospital. LSSR might lower the prevalence of HNP with LBP and might increase the prevalence of scoliosis with LBP.
The roles of purple sweet potato anthocyanins in optimizing dietary intervention of metabolic dysfunction-associated fatty liver disease
Authors: Awan Syuma Adhy , Wibawa I Dewa Nyoman , Jawi I Made , Pinatih Gde Ngurah Indraguna , Mahendra Agung Nova 
Published: May 2024

Link of Video Abstract: https://youtu.be/rRJRhubdmcM

Metabolic-associated fatty liver disease (MAFLD) is a multifactorial metabolic disorder with complex pathogenesis and a broad spectrum of disease. It is characterized by the accumulation of triglycerides (TG) in hepatocytes, which are associated with hepatic steatosis. Purple sweet potato (Ipomoea batatas L.) (PSP) tuber, is rich in anthocyanin contents. This review aims to discuss recent findings on the effects of purple sweet potato tubers and its potential therapeutic action on MAFLD. In various in vivo studies and limited clinical trials on patients, purple sweet potatoes have been shown to be beneficial not only in lipid metabolism but also in reducing liver fat deposition and insulin resistance. In addition to antioxidant, anti-inflammatory, and anti-hyperlipidemic effects, anthocyanins can be considered as important adjuvant therapeutic agents in the attenuation of inflammation, free radicals, insulin resistance, and hepatocyte injury.
The Impact of COVID-19 after one year on the orthopedic spine service at the Orthopedic Center Hospital in Indonesia
Authors: Utomo Pamudji , Santoso Hafizh Nur , Dykall Naf’an Dzikri  
Published: May 2024

link of Video Abstract: https://youtu.be/-6sruWeh-_Q

Introduction: Coronavirus-2 (SARS-COV2) is the agent that causes Coronavirus Disease (COVID-19), an acute respiratory tract illness. Early in December 2019, COVID-19 was created in Wuhan, China. On March 11th, 2020, COVID-19 was classified as a pandemic by WHO. As a result, the Indonesian government enacted extensive social restrictions on March 31, 2021. This rule prohibits unnecessary public actions. This study aimed to ascertain how COVID-19 affected This study sought to ascertain how COVID-19 affected orthopedic treatments provided in the spine area at the Orthopaedic Center Hospital in Indonesia.
Methods: This research is cross-sectional and comparative. The population in Indonesia during the COVID-19 epidemic was compared to the same population one year earlier in the research. This report covers every patient who visited Prof. Dr. R. Soeharso Orthopaedic Hospital with a spine-related diagnosis from the emergency room, an outpatient clinic, or an inpatient setting. Patients with other orthopedic subspecialty diagnoses and those registered at orthopedic service support facilities like radiography, laboratories, or physiotherapy were excluded. SPSS version 26 was used to analyze the data.
Results: The overall number of spine patients decreased significantly (30%) from 2440 (pre-covid) to 1695 (during covid). Additionally, there was a significant decline in outpatient visits and surgical procedures (p≤0.05). Patients with trauma reported a crucial decrease during outpatient visits and during surgery (p≤0.05).
Conclusions: During the COVID-19 pandemic, the overall number of spine patients from outpatient visits and patient surgery decreased significantly. Additionally, orthopedic care provided during outpatient visits and surgeries decreased.
Posterior annulus elevation using pledget stitch: An adjuvant technique to improve the mitral valve coaptation in pediatric mitral valve repair
Authors: Rahmat Budi , Siswanto Bambang Budi , Fakhri Dicky , Sakidjan Indriwanto , Sulisetyowati Tri Wahyu Murni , Timan Ina Susianti , Kekalih Aria , Kurniawati Yovi , Wardana Putu Wisnu Arya , Fardhani Dwi Gunawan 
Published: May 2024

Link of Video Abstract: https://www.youtube.com/watch?v=8PNO8KPQFTY

Purpose: Achieving an optimal result in mitral valve repair can be challenging in children due to the delicate nature of the mitral valve tissue, a wide range of pathologies, and a high incidence of co-existing cardiac anomalies. This study aimed to evaluate a novel adjuvant technique, posterior annulus elevation using pledget stitch, to improve mitral valve coaptation in pediatric mitral valve repair.

Patients and methods: A retrospective cohort study was conducted at the National Cardiovascular Center Harapan Kita. Patients with severe mitral regurgitation who underwent mitral valve repair with posterior annulus elevation using pledget stitch between January 2021 and October 2021 were included. Transesophageal echocardiography (TEE) at day-0 and transthoracic echocardiography (TTE) at day-5 and 3 months after surgery was performed to assess coaptation length and residual regurgitation.

Results: Twelve patients were included in this study with a mean age of 13.13 ± 2.98 years. The mean coaptation length was 6.94 ± 1.44 mm immediately after surgery. At day 5, 11 patients exhibited no or only trivial regurgitation (91.67%), with a mean coaptation length of 7.18 ± 1.72 mm. During a three-month follow-up period, 10 patients had no or only trivial regurgitation (83.33%) with the rest only developing mild regurgitation (16.67%), with a mean coaptation length of 7.60 ± 1.41 mm. No mortality or adverse events related to the procedure were observed during the follow-up.

Conclusion: Posterior annulus elevation using pledget stitch as a novel adjuvant technique during mitral valve repair showed promising results in improving leaflet coaptation in pediatric patients. This technique may provide an additional option for mitral valve repair when the conventional technique yields unsatisfactory results.
Borderline type leprosy with variation of clinical manifestations and histopathology: two case reports
Authors: Karmila I Gusti Ayu Agung Dwi , Rusyati Luh Made Mas , Saputra Herman , Sari Luh Gede Melia Puspita 
Published: May 2024

Link of Video Abstract: https://youtu.be/HgIJyHrxoOc

Background: Leprosy is a chronic disease caused by Mycobacterium leprae. This disease can be diagnosed if one of the four criteria is met. Histopathological examination can vary depending on the spectrum of the disease. The following describes two cases of borderline-type leprosy that aimed to increase understanding of the diagnosis and management of leprosy, especially the borderline type.
Cases: Both cases had complaints of numb spots on the body. The first case had more lesions than the second one with borderline-borderline histopathological examination results, while the second one had borderline lepromatous histopathological examination results. Both patients received the same therapy (multidrug therapy for multibacillary leprosy). During observation, there were no drug side effects that the patient could not tolerate. The prognosis in both cases is dubia, depending on the patient's adherence to treatment.
Conclusion: The diversity of clinical and histopathological features can occur, including cases of leprosy. Early diagnosis and prompt treatment should be started as possible to prevent disabilities.
The role of the immune response in the development of pneumonia arising from oral periodontitis: a literature review
Authors: Hutomo Suryani , Denise Utami Putri  
Published: May 2024

Link of Video Abstract: https://youtu.be/Cgi15seZAw4

A growing evidence links periodontitis, a chronic inflammatory disease of the oral cavity, to the development of systemic inflammation. One of the most commonly reported is pneumonia, arising from aspiration of the periodontal pathogens into the lung tissue. In high-risk individuals, the morbidity and mortality rate is high, raising the concern for prevention measures. Secondary systemic effects are proposed to arise from both direct periodontal pathogens spread and through leakage of bacterial byproducts and local inflammatory cytokines to the bloodstream. The association of periodontitis and systemic diseases is bi-directional, as systemic diseases may, in turn, increase the incidence and severity of periodontal diseases. Here, the conflicting roles of the immune system in both limiting pathogen growth and its potential catastrophic inflammatory activation is further discussed. In addition, possible approaches to prevent periodontitis from spreading into the respiratory organs are also proposed. Given the large number of the population affected by periodontitis, a comprehensive understanding of the pathomechanisms of the development of systemic diseases, notably pneumonia, as well as the discovery of prevention and therapeutic approaches, is urgently needed.
Characteristic of upper respiratory tract microbiota in severe covid-19 adult patients in Indonesia
Authors: Angky Budianti  , Dewi Beti Ernawati , Sudiro Tjahjani Mirawati , Nainggolan Leonard , Prihartono Joedo , Jauharoh Siti Nur Aisyah , Suwarto Suhendro , Sjahrurachman Agus 
Published: May 2024

Introduction: Nowadays, new cases of COVID-19 have been found with severe cases and deaths. The upper respiratory microbiota has been associated with susceptibility to viral infection and disease severities. However, the association of respiratory tract microbiota with the modulation of COVID-19 outcomes still raises a question. Therefore, we examined the association between the diversity of upper respiratory microbiota and clinical manifestations of COVID-19.
Methods: This research is an observational cross-sectional study. We characterized the microbiota in the upper airway using the 16S ribosomal RNA sequencing method in 74 COVID-19 patients aged 18-64 years. We also examined the association between COVID-19 severities with alpha and beta diversity of upper respiratory microbiota. The alpha and beta diversity was analyzed by QIIME and shown by R software, AMOVA and MRPP testing was done with R software. The t test and diagrams were performed using R software. Bivariate analysis was carried out by t-test and Chi-square test.
Results: The top five phyla in the upper respiratory tract of Indonesian COVID-19 patients with age 18-64 years old were Firmicutes (32,3%), Bacteroidota (27,1%), Fusobacteriota (15,2%), Proteobacteria (15,1%) and Actinobacteria (7,1%). Shannon and ACE index analysis showed no decline of microbiota diversity in the upper airway with increased disease severity. However, there were significant beta diversity differences in the upper airway microbiota between mild and severe COVID-19. The Firmicutes phylum and Oribacterium genus abundance were significantly higher in severe COVID-19 than in mild. The quantity of the Fusobacteriota phylum, Neisseria, and Fusobacterium genera was significantly higher in mild COVID-19 than in severe.
Conclusion: Our research supports the relationship between the severity of COVID-19 and the diversity of the microbiota in the upper airway in adults. Further studies are needed to examine how microbiota prevents COVID-19 severities.
Relationship between transforming growth factor beta 1 (TGF-ß1) level and skin tag
Authors: Dewi Sisilia Kesuma , Putra Imam Budi , Jusuf Nelva Karmila 
Published: May 2024

Background: Skin tag, also known as acrochordons, are benign neoplasms that look like a protrusion skin growth. Multifactorial causes of skin tags such as aging, obesity, metabolic and hormonal disorders. One of the mechanisms for the occurrence of skin tags by repeated scratching or friction trauma and continuously triggers an inflammatory response. During inflammation, TGF-ß1 has been activating to prevent the adhesion of neutrophils and T cells to endothelial cells, then limiting the recruitment of inflammatory cells. In addition, TGF-β1 expression is the main promoter in fibroblast proliferation and collagen synthesis as a response to cell repair function. This study aims to determine the relationship between TGF-ß1 level and skin tags.
Methods: This observational study has a cross-sectional design of 39 skin tag patients and 40 non-skin tags. Each patient underwent history taking, dermatological examination, then took the blood sampling to analyze the TGF-ß1 level using the ELISA test. These data were statistically analyzed with the Mann-Whitney analytic test.
Results: The average TGF-β1 level on skin tags group was 549.05±173.52 ng/ml. Most subjects with skin tags had 1–5 lesions, were 24 people (61.5%). The most common type of skin tag was pedunculated in 9 people (23.1%), followed by the drop form in 6 people (15.3%) and the spherical in 6 people (15.3%). The majority shows that 16 people (41%) have more than one type of skin tag in one region. The results of this study reveal that there is a relationship between TGF-β1 low level and skin tags.
Conclusion: There is a significant relationship between TGF-β1 and skin tags.
Proceeding Article Annual Scientific Meeting of PAMKI in Conjunction with The 3rd Global health and Innovation Conference 2023
Authors: PAMKI  
Published: May 2024

Dear Colleagues,
It was a true honor that we accept colleagues at the Annual Scientific Meeting of PAMKI in Conjunction with The 3rd Global health and Innovation Conference 2023 that was held on West Lombok, Indonesia on July 7-8th 2023.
The theme of this conference was "Combating Antimicrobial Resistance: Strengthening Collaboration and Nurturing Innovation". The event is expected to update and improve the knowledge in microbiology, particularly about antimicrobial resistance. This conference also contributed for the venue of reunion and brainstorming sessions with peers in arms.
The proceeding article contains articles that were accepted for publication to Bali Medical Journal (BMJ).
Finally, we would like to thank the committee, reviewer, and another scientific team who dedicating to finalized this proceeding article. We hope to be able to meet with all of you soon on the next event.
A five-year study of Kikuchi Fujimoto Disease in Dr. Cipto Mangunkusumo National Central General Hospital
Authors: Naswa Syakira Maulana  , Agnes Stephanie Harahap  , Alif Gilang Perkasa  , Jonathan Ariel  , Salinah  , Maria Francisca Ham  
Published: May 2024

Link of Video Abstract: https://youtu.be/4GFvBGh4sdI

Background: Kikuchi Fujimoto Disease (KFD) is a disease characterized by regional lymphadenopathy and fever. KFD is often misdiagnosed as tuberculosis because of the symptom’s similarities. Several studies have shown KFD prevalence in Asia, however, not much is known about KFD characteristics in Indonesia. This study aimed to determine KFD clinicopathological characteristics in an Indonesian National Central General Hospital and to determine the association between clinical characteristics and KFD histopathological features.
Methods: Samples were taken from the medical records of patients with KFD in the span of 2016–2020. The data collected includes age, gender, lymphadenopathy location, clinical diagnosis, clinical symptoms, lymph node size, number of lymph nodes involved, histopathology, and immunohistochemical examination. Data were analyzed using Chi-square and Fisher exact test.
Result: It was found that KFD mainly occurred in young women, mean age 25 years old, located in cervical lymphadenopathy, ≤ 2 cm size, and solitary. The main histopathological appearance is phagocytic subtype and necrotic phase, with < 50% coagulative necrosis area. It also appeared KFD with < 50% coagulative necrosis area was found significantly in ≤ 2 cm lymph nodes (p = 0.008).
Conclusion: Clinical characteristics and complete histopathological features are important to be assessed in KFD to achieve accurate diagnosis.
Obesitas pada kehamilan sebagai faktor risiko terjadinya serum IL– 6 dan TNF- α maternal yang tinggi
Authors: Putra I Wayan Artana , Widiyanti Endang Sri , Wanaditya Glenn Kristie , Sumada I Made Agus Cakhantara 
Published: May 2024

Background: Obesity in pregnancy is currently a health problem that is associated with increased maternal and neonatal morbidity. This is thought to be caused by high levels of pro-inflammatory cytokines interleukin (IL-6) and tumour necrosis factor alpha (TNF-α) which are triggered by obesity itself and pregnancy. The aim of this study was to determine whether obesity in pregnancy is a risk factor for high serum IL-6 and TNF alpha.
Methods: This research is a cross-sectional analytical study on 58 pregnant women with obesity (as a risk factor) and without obesity who came to the Polyclinic and Obstetrics Emergency Room at Prof. Dr. I.G.N.G. Ngoerah General Hospital were selected sequentially (consecutive sampling) and met the inclusion and exclusion criteria. Serum IL-6 and TNF alpha were taken from the mother's blood and then measured using the Enzyme-linked immunoassay (ELISA) method.
Results: High levels of IL-6 were found to be significant in 20 obese pregnant women (68.9%) and 11 non-obese pregnant women (37.9%) (Prevalence Ratio (PR) 1.81; p 0.019). High levels of TNF alpha were also found to be significant in 23 obese pregnant women (79.3%) and 13 non-obese pregnant women (44.8%) (Prevalence Ratio (PR) 1.77; p 0.007).
Conclusion: Obesity in pregnancy is a risk factor for high serum IL-6 and TNF alpha.

Latar belakang: Obesitas pada kehamilan saat ini menjadi masalah kesehatan yang dihubungkan dengan peningkatan morbiditas pada maternal dan neonatal. Hal ini diduga diakibatkan oleh tingginya sitokin proinflamasi interleukin 6 (IL-6) dan tumor necrosis factor alpha (TNF-α) yang dipicu oleh obesitas itu sendiri dan keadaan kehamilan. Tujuan penelitian ini adalah untuk mengetahui apakah obesitas pada kehamilan merupakan faktor risiko terjadinya serum IL-6 dan TNF alfa yang tinggi.
Metode: Penelitian ini merupakan penelitian analitik potong lintang pada 58 wanita hamil dengan obesitas (sebagai faktor risiko) dan tanpa obesitas yang datang ke Poliklinik dan IGD Kebidanan RSUP Prof. Dr. I.G.N.G. Ngoerah Denpasar yang dipilih secara berurutan (consecutive sampling) dan memenuhi kriteria inklusi dan eksklusi. Serum IL-6 dan TNF alfa diambil dari darah ibu dan kemudian diukur menggunakan metode enzyme-linked immunoassay (ELISA).
Hasil: Kadar IL-6 yang tinggi didapatkan signifikan pada 20 wanita hamil dengan obesitas (68,9%) dan 11 wanita hamil tidak obesitas (37,9%) (Prevalence Ratio (PR) 1,81; p 0,019). Kadar TNF alfa yang tinggi juga ditemukan signifikan pada 23 wanita hamil dengan obesitas (79,3%) dan 13 wanita hamil tidak obesitas (44,8%) (Prevalence Ratio (PR) 1,77; p 0,007).
Simpulan: Obesitas pada kehamilan merupakan faktor risiko terjadinya serum IL-6 dan TNF alfa yang tinggi.