bluuebunny/crossref_metadata_2025_split huggingface dataset:
Whole‐Body Hyperthermia
Authors: Page R. L. , Thrall D. E. , Dewhirst M. W. , Meyer R. E. 
Published: March 2010

Whole‐body hyperthermia is the controlled elevation of systemic temperature for therapeutic purposes. Historically, this treatment has been used for symptomatic control of many diseases. Recently, the potential therapeutic benefit of whole‐body hyperthermia in the management of neoplastic disease has been investigated vigorously. The rationale for improved tumor control is based on heat‐induced enhancement of the antineoplastic effects of radiation and chemotherapy. Although the complex biologic interaction of heat and radiation has been studied for many years, chemotherapy combined with hyperthermia has been studied less thoroughly. Despite a lack of adequate long‐term laboratory and clinical investigation, use of whole‐body hyperthermia with chemotherapy and radiotherapy is a logical and potentially powerful therapeutic strategy for neoplasia.Relevant issues regarding the application of whole‐body hyperthermia with more traditional modes of therapy are being studied in preliminary clinical trials involving dogs and humans. Identification of optimal timing and sequencing of adjunctive therapy, proper cytotoxic drug application, methods to further minimize toxicity, and heat‐sensitive tumor types will lead to expanded clinical use of whole‐body hyperthermia.The historical development, clinical rationale, and application of whole‐body hyperthermia for the control of disseminated or refractory neoplasia in humans and dogs is reviewed.
Comparison of Virulence Factors and Antibiotic Resistance Profiles of Escherichia coli Strains From Humans and Dogs With Urinary Tract Infections
Authors: Nolan L. K. , Wooley R. E. , Brown J. , Blue J. L. , Camp M. 
Published: March 2010

The purpose of this study was to compare virulence factors and antibiotic resistance profiles of Escherichia coli strains isolated from dogs and humans with urinary tract infections. Factors studied included resistance to antibiotics and the transferability of R‐plasmids to a recipient E. coli; production of colicins, hemolysins, beta‐lactamase, and urease; hemagglutination of erythrocytes; and fermentation of dulcitol.The canine E. coli isolates had a wider range of antibiotic resistance and a higher R‐plasmid trans‐missibility rate. A higher percentage of the canine isolates produced colicins (40% vs. 24%), hemolysins (44% vs. 16%), beta‐lactamase (52% vs. 4%), and fermented dulcitol (84% vs. 80%) as compared with the human isolates. The human isolates had a greater ability to hemagglutinate erythrocytes as compared with the canine isolates (24% vs. 8%). None of the isolates produced urease.
Factors Affecting Prognosis and Conversion in Equine Atrial Fibrillation
Authors: Reef Virginia B. , Levitan Chelsie W. , Spencer Pamela A. 
Published: March 2010

Sixty‐seven horses presented with atrial fibrillation (AF) from January I, 1980 to August 1, 1986. All horses were evaluated for the type and severity of the underlying cardiac disease and the probable duration of the arrhythmia. Fifty‐two (78%) of the horses were treated with quinidine sulfate and/or digoxin. The response to treatment was assessed in each horse. Horses were followed for periods extending from 8 months to 7 years.Standardbreds, young horses, and males predominated in the study group. There were more male horses (stallions and geldings) than mares. Most horses with AF had no evidence of other cardiac disease (56.7%). All performance horses without other cardiac disease were treated, and return to performance was significantly associated with conversion to sinus rhythm. Horses that did not convert with quinidine sulfate therapy, whose arrhythmia recurred, and that had side effects from quinidine sulfate therapy, had a longer history of poor performance. Tachycardia (heart rate > 60 beats/min) was significantly associated with the existence of congestive heart failure. The horses with congestive heart failure had a poor prognosis for life (7.7% survived) and a poor conversion to normal sinus rhythm (23.1 %).Mitral regurgitation (19 horses) was the most common underlying cardiac disease. Tricuspid regurgitation (15 horses), aortic regurgitation (3 horses), myocardial dysfunction (3 horses), and atrial septal defect (1 horse) also were diagnosed. Congestive heart failure was common in this group of horses with underlying cardiac disease.
Therapy of Immune Mediated Thrombocytopenia
Authors: Jans Heather E. , Armstrong P. Jane , Price G. Sylvester 
Published: March 2010

Fifteen dogs with immune mediated thrombocytopenia (IMT) were studied retrospectively. All dogs had a thrombocyte count below 50,000/μl when response to therapy was studied. Platelet counts greater than 50,000/μl were present in all dogsl within 2–9 days of initiating medical therapy. Eight dogs experienced a single episode of thrombocytopenia and seven dogs relapsed over the following 5 to 24 months. Clinical parameters from dogs that experienced a single episode of IMT were compared with data from dogs that relapsed to determine whether any information would identify dogs that were prone to relapse. Signalment, severity of thrombocytopenia, and time to achieve a platelet count above 50,000/μl were found not to differ (P> 0.05) between these two groups.Five of the seven dogs with relapsing IMT were splenectomized after 2 to 4 episodes (mean, 2.8 ± 0.8) of thrombocytopenia over 2 to 14 months. The postoperative progress of these five dogs was followed for 6 to 17 months. Platelet counts were sustained above 200,000/μ1 in 4/5 after splenectomy and it was possible to discontinue medical therapy in these dogs. In comparison, the 2 relapsing IMT cases that were not splenectomized continued to require intermittent immunosuppressive therapy.We conclude that signalment and routine pretreatment laboratory test results are not useful in distinguishing dogs with relapsing IMT from those that will experience one episode of IMT. Seemingly, splenectomy is useful in the management of dogs with relapsing IMT. (Journal of Veterinary Internal Medicine 1990; 4:4–7)
Morphologic Changes in the Lungs of Cats Experimentally Infected WithDirofilaria immitis
Authors: Rawlings Clarence A. , Farrell Robert L. , Mahood Richard M. 
Published: March 2010

The morphologic response of the pulmonary arteries and lungs in cats was studied after a five month heartworm infection produced by transplantation of four adult heartworms/cat. One group of seven heartworm infected cats was not treated, another group of seven cats was treated with 97.5 mg of aspirin given twice a week, and the third group of six cats was given aspirin at a sufficient dosage to blockin vitroplatelet aggregation throughout the study. A fourth group of eight noninfected cats served as controls. Five months after heartworm infection, the cats were euthanized and the lungs perfusion fixed for light microscopy and scanning electron microscopy of the pulmonary arterial surfaces.All cats in the three heartworm‐infected groups had live heartworms and the typical pulmonary arterial changes of heartworm disease at necropsy. The arterial surfaces, as viewed with scanning electron microscopy, had villus proliferations that were more numerous and exuberant than similar infections in dogs. Mean percentage of arterial surface involvement with villus proliferation of the nontreated heartworm infected cats was 67.3%; the aspirin treated cats, 73.8%; and the adjusted aspirin treated cats, 75.9%. The villi were myointimal proliferations in the small and medium‐sized arteries. The more elastic arteries had a predominance of fibromuscular proliferation. All heartworm infected cats had arterial muscular hypertrophy of the small arteries, in contrast to only three of eight of the nonheartworm infected cats. The caudal lobar arteries were frequently obstructed with either villus proliferation, thrombi, and/or dead heartworms. The muscular arteries had branches with marked dilation, a condition associated with pulmonary hypertension in man. However, only three cats, one in each group, had pulmonary hypertension. The adjusted aspirin group had less arteriosclerosis and thrombosis than the other two heartworm‐infected groups. There were no statistical differences between the heartworm groups with respect to arterial muscular hypertrophy, myointimal proliferation with and without eosinophilia, vein‐like dilations of the muscular arterial branches, and percentage of arterial surface with villus proliferation.Aspirin, when given at platelet inhibiting doses, reduced only a portion of the pulmonary response to heartworms in these cats. It was presumed that the inflammatory response to heartworms in the cat is so severe that trophic factors other than those released by platelets can also produce arterial disease. Based upon this study, aspirin is not recommended for heartworm disease in the cat.
Radiographic and Scintigraphic Evidence of Focal Pulmonary Neoplasia in Three Cats With Hyperthyroidism: Diagnostic and Therapeutic Considerations
Authors: Cook Suzanne M. , Daniel Gregory B. , Walker Michael A. , Maddux Jeanne M. , Jenkins Christine C. , Klebanow Edward R. , Bouley Donna M. , Dean David F. , Petersen Mark G. 
Published: March 2010

Three cats were diagnosed as hyperthyroid based on clinical signs, historical findings, laboratory abnormalities, and basal serum thyroxine (T4) concentrations, and/or nuclear thyroid scans. Additionally, a presumptive diagnosis of thyroid carcinoma with pulmonary metastasis was made in each cat based on radiographic or scintigraphic evaluation. All three cats had solitary pulmonary nodules 1.5 to 2 cm in diameter on survey thoracic radiographs; one cat also had chylous pleural effusion and pulmonary lobar consolidation. Focal pulmonary accumulation of sodium pertechnetate (99mTcO4‐) and/or radioiodine (131I) corresponding to radiographic lesions were seen in all cats. Two cats were treated with single ablative doses (1111 to 1480 MBq) of131I; the remaining cat was euthanatized.One of the treated cats died 8 days later; the other cat was euthanatized 22 weeks following treatment. Histopathologic examination of tissue obtained at necropsy confirmed metastatic thyroid carcinoma in one cat and bronchogenic adenocarcinoma in two cats. Our findings indicate that increased radionuclide uptake in focal pulmonary lesions and cytologic evaluation of tissue obtained by fine‐needle aspiration are not specific for thyroid tissue. (Journal of Veterinary Internal Medicine 1993; 7:303–308. Copyright © 1993 by the American College of Veterinary Internal Medicine.)
The First 25 Years of the American College of Veterinary Internal Medicine
Authors: Willoughby Russell A. 
Published: March 2010

SummaryIn a brief period of 25 years the ACVIM has developed from an idea into one of the leading specialties in veterinary medicine. The varied training, experience, and backgrounds of the specialists who designed the College were the necessary basis from which high but attainable standards were established. The continued involvement and interactions of the diplomates with organized veterinary medicine, species and client groups, allied specialty groups, and research organizations have enabled the College to remain at the cutting edge of the clinical sciences. The contacts that undergraduate veterinary students have with diplomates in veterinary teaching hospitals, along with attendance at the ACVIM Forum and the Journal, encourage many to undertake careers in one of the specialties of the College.The collegial atmosphere within the ACVIM that began in its formative years is a hallmark of the College. That atmosphere continues to be fostered by acquaintances that interns and residents establish during their training programs, during examinations, and while presenting and attending papers at the Forum. Many collaborative educational and research projects have emerged from these networks. In many cases, diplomates have decided to accept positions or pay visits because of these friendships.The ACVIM is a caring organization that treasures the creation of new knowledge and its ability to share that knowledge with its main public—the veterinary profession and others responsible for the care of animals.May it always be so.
Hepatic Lipidosis in Anorectic, Lactating Holstein Cattle: A Retrospective Study of Serum Biochemical Abnormalities
Authors: Cebra Christopher K. , Garry Franklyn B. , Getzy David M. , Fettman Martin J. 
Published: March 2010

The association between hepatic lipidosis (HL) and disease in 59 anorectic, ketotic, lactating Holstein heifers and cows was investigated. Severe HL, as determined by histologic evaluation of liver tissue, was present in 46 animals; only half of these animals required intensive treatment for ketosis, and only half had serum biochemical evidence of liver disease, as determined by the presence of a test value of 2‐fold or greater than the upper limit of the reference range for at least 2 of the 4 serum tests: gamma‐glutamyl transferase, aspartate aminotransferase, and sorbitol dehydrogenase activities and bile acid concentrations. Most cattle with biochemical evidence of liver disease and severe HL had been lactating for 14 or more days. Cows that required intensive treatment inconsistently had serum biochemical evidence of liver disease.Although cattle with severe HL had significantly higher serum bilirubin concentrations and aspartate aminotransferase and sorbitol dehydrogenase activities than cattle with less severe lipidosis, the specificity of abnormally high serum sorbitol dehydrogenase activity or bilirubin concentration for severe lipidosis was only 8%. Abnormally high serum aspartate aminotransferase activity was 83% sensitive and 62% specific for severe lipidosis. Serum glucose and total carbon dioxide concentrations were significantly lower in cattle with severe lipidosis than in those with mild or moderate lipidosis, and low serum glucose or total carbon dioxide concentrations were rare in cattle without severe lipidosis. From these data, we conclude that the use of a single biochemical or histopathologic criterion to define severity of disease or degree of liver compromise in anorectic, ketotic cows results in the misidentification of many animals.
Comparison between Swan conductors and characteristic cycles
Authors: Abe Tomoyuki 
Published: March 2010

AbstractIn this paper, we define Swan conductors for unit-root overconvergent F-isocrystals using the theory of arithmetic 𝒟-modules due to Berthelot. Our Swan conductors are compared with the Swan conductors for ℓ-adic sheaves constructed by Kato and Saito using a geometric method. As an application, we prove the integrality of Swan conductors in the sense of Kato and Saito under the ‘resolution of singularities’ assumption.
On the potential automorphy of certain odd-dimensional Galois representations
Authors: Barnet-Lamb Thomas 
Published: March 2010

AbstractIn a previous paper, the potential automorphy of certain Galois representations to GLn for n even was established, following the work of Harris, Shepherd–Barron and Taylor and using the lifting theorems of Clozel, Harris and Taylor. In this paper, we extend those results to n=3 and n=5, and conditionally to all other odd n. The key additional tools necessary are results which give the automorphy or potential automorphy of symmetric powers of elliptic curves, most notably those of Gelbert, Jacquet, Kim, Shahidi and Harris.
Optimization of
Steel Monopod-Offshore-Towers Under Probabilistic
Constraints
Authors: Karadeniz Halil , Togan Vedat , Vrouwenvelder Ton 
Published: March 2010

Abstract
In this work, economical design implementation of a circular steel monopod-offshore-tower, which is subjected to the extreme wave loading, is presented. The mass of the tower is considered as the objective function. The thickness and radius of the cross section of the tower are adopted as design variables of the optimization. Moreover, stress or buckling is specified as probabilistic constraints. The numerical strategy employed for performing the optimization uses the International Mathematics and Statistics Library (IMSL) routine that is based on the sequential quadratic programming. The first-order reliability method (FORM) is used for the reliability calculation from a specified limit state function based on the stress or buckling. A demonstration of an example monopod tower is presented.
First Case of Human “
Candidatus
Neoehrlichia mikurensis” Infection in a Febrile Patient with Chronic Lymphocytic Leukemia
Authors: Welinder-Olsson Christina , Kjellin Eva , Vaht Krista , Jacobsson Stefan , Wennerås Christine 
Published: March 2010

ABSTRACT

An immunocompromised patient presented with febrile episodes, an erysipelas-like rash, and thromboembolic complications. Amplification of 16S rRNA gene sequences from blood and sequence analysis revealed “
Candidatus
Neoehrlichia mikurensis.” We report the first case of human disease caused by “
Ca
. Neoehrlichia mikurensis.”
Effectiveness of once-weekly gym-based exercise programmes for older adults post discharge from day rehabilitation: a randomised controlled trial
Authors: Foley A , Hillier S , Barnard R 
Published: March 2010

ObjectiveTo determine whether high-intensity, progressive gym-based exercise performed once a week is as effective as twice weekly for maintaining both subjective and objective outcomes in older adults post discharge from a metropolitan day rehabilitation centre (DRC).DesignRandomised controlled trial.SettingCommunity-based exercise centre for older adults, located in Metropolitan Adelaide, South Australia.Participants21 men and 85 women who completed the DRC programme were assessed and randomly allocated to a study group.InterventionThe two experimental interventions were gym-based exercise programmes (including resistance, aerobic, flexibility and balance training) varying only in frequency of delivery: either once or twice a week, directly compared with usual care (control).Main outcome measuresLower limb strength (one-repetition maximum), balance (Berg Balance Scale), physical function (gait speed, 30-s chair stand test, timed up and go test (primary outcome) and 6-min walk test), self-reported pain (Glasgow Pain Questionnaire), activities of daily living (Barthel Index and Older Americans Resources and Services Multidimensional Functional Assessment Questionnaire), perceived benefits of and barriers to exercise (Exercise Benefits Barriers Scale), quality of life (Assessment of Quality of Life Questionnaire) and exercise frequency preference.ResultsMost of the outcomes (69%, 11/16) were maintained over the intervention period with no significant group effects detected between the two intervention groups or compared to the control group. Physical activity levels recorded in the control group showed a significant proportion of participants were actively exercising once weekly. A per-protocol analysis was undertaken to take this potential contamination effect into account. This showed that the control group participants, who did not exercise, did not maintain outcomes to the extent of the intervention groups, with significant group-by-time effects detected between the two intervention groups and the control group. Most of all participants (66%, 62/94) nominated once a week as their preferred exercise frequency.ConclusionsThe overall finding of no significant differences between the two intervention groups for all outcomes measured gives support to the effectiveness of once-a-week exercise in maintaining outcomes at 3 months post rehabilitation. Further research is warranted given the once-a-week exercise intervention should cost less, had higher compliance and was nominated as the preferred exercise frequency by most of the participants.
The challenge of low physical activity during the school day: at recess, lunch and in physical education
Authors: Nettlefold L , McKay H A , Warburton D E R , McGuire K A , Bredin S S D , Naylor P J 
Published: March 2010

PurposeTo describe physical activity (PA) intensity across a school day and assess the percentage of girls and boys achieving recommended guidelines.MethodsThe authors measured PA via accelerometry in 380 children (8–11 years) and examined data representing (1) the whole school day, (2) regular class time, (3) recess, (4) lunch and (5) scheduled physical education (PE). Activity was categorised as sedentary (SED), light physical activity (LPA) or moderate to vigorous physical activity (MVPA) using age-specific thresholds. They examined sex differences across PA intensities during each time period and compliance with recommended guidelines.ResultsGirls accumulated less MVPA and more SED than boys throughout the school day (MVPA −10.6 min; SED +13.9 min) recess (MVPA −1.6 min; SED +1.7 min) and lunch (MVPA −3.1 min; SED +2.9 min). Girls accumulated less MVPA (−6.2 min), less LPA (−2.5 min) and more SED (+9.4 min) than boys during regular class time. Fewer girls than boys achieved PA guidelines during school (90.9% vs 96.2%), recess (15.7% vs 34.1%) and lunch (16.7% vs 37.4%). During PE, only 1.8% of girls and 2.9% of boys achieved the PA guidelines. Girls and boys accumulated similar amounts of MVPA, LPA and SED.ConclusionThe MVPA deficit in girls was due to their sedentary behaviour as opposed to LPA. Physical activity strategies that target girls are essential to overcome this deficit. Only a very small percentage of children met physical activity guidelines during PE. There is a great need for additional training and emphasis on PA during PE. In addition schools should complement PE with PA models that increase PA opportunities across the school day.
Antitumor and Anti-inflammatory Effects of Trabectedin on Human Myxoid Liposarcoma Cells
Authors: Germano Giovanni , Frapolli Roberta , Simone Matteo , Tavecchio Michele , Erba Eugenio , Pesce Samantha , Pasqualini Fabio , Grosso Federica , Sanfilippo Roberta , Casali Paolo G. , Gronchi Alessandro , Virdis Emanuela , Tarantino Eva , Pilotti Silvana , Greco Angela , Nebuloni Manuela , Galmarini Carlos Maria , Tercero Juan Carlos , Mantovani Alberto , D'Incalci Maurizio , Allavena Paola 
Published: March 2010

Abstract
Inflammatory mediators present in the tumor milieu may promote cancer progression and are considered promising targets of novel biological therapies. We previously reported that the marine antitumor agent trabectedin, approved in Europe in 2007 for soft tissue sarcomas and in 2009 for ovarian cancer, was able to downmodulate the production of selected cytokines/chemokines in immune cells. Patients with myxoid liposarcoma (MLS), a subtype characterized by the expression of the oncogenic transcript FUS-CHOP, are highly responsive to trabectedin. The drug had marked antiproliferative effects on MLS cell lines at low nanomolar concentrations. We tested the hypothesis that trabectedin could also affect the inflammatory mediators produced by cancer cells. Here, we show that MLS express several cytokines, chemokines, and growth factors (CCL2, CCL3, CCL5, CXCL8, CXCL12, MIF, VEGF, SPARC) and the inflammatory and matrix-binder protein pentraxin 3 (PTX3), which build up a prominent inflammatory environment. In vitro treatment with noncytotoxic concentrations of trabectedin selectively inhibited the production of CCL2, CXCL8, IL-6, VEGF, and PTX3 by MLS primary tumor cultures and/or cell lines. A xenograft mouse model of human MLS showed marked reduction of CCL2, CXCL8, CD68+ infiltrating macrophages, CD31+ tumor vessels, and partial decrease of PTX3 after trabectedin treatment. Similar findings were observed in a patient tumor sample excised after several cycles of therapy, indicating that the results observed in vitro might have in vivo relevance. In conclusion, trabectedin has dual effects in liposarcoma: in addition to direct growth inhibition, it affects the tumor microenvironment by reducing the production of key inflammatory mediators. Cancer Res; 70(6); 2235–44