bluuebunny/crossref_metadata_2025_split huggingface dataset:
Determinants and risk factors for renal damage: where do patients hospitalized for severe anorexia nervosa stand? A multi-center study
Authors: Stheneur Chantal , Blanchet Corinne , Mattar Lama , Dicembre Marika , Wilson Kayigan ,   EVHAN Group, Duclos Jeanne , Roux Hélène , Thiébaud Marie-Raphaële , Vibert Sarah , Hubert Tamara , Courty Annaig , Ringuenet Damien , Benoit Jean-Pierre , Moro Marie-Rose , Bignami Laura , Nordon Clémentine , Rouillon Frédéric , Cook Solange , Doyen Catherine , Mouren Marie-Christine , Gerardin Priscille , Lebecq Sylvie , Podlipski Marc-Antoine , Gayet Claire , Lasfar Malaika , Delorme Marc , Pommereau Xavier , Bioulac Stéphanie , Bouvard Manuel , Carrere Jennifer , Doncieux Karine , Faucher Sophie , Fayollet Catherine , Prexl Amélie , Billard Stéphane , Lang François , Mourier-Soleillant Virginie , Greiner Régine , Gay Aurélia , Carrot Guy , Lambert Sylvain , Rousselet Morgane , Placé Ludovic , Venisse Jean-Luc , Bronnec Marie , Falissard Bruno , Genolini Christophe , Hassler Christine , Tréluyer Jean-Marc , Chacornac Olivier , Delattre Maryline , Moulopo Nellie , Turuban Christelle , Auger Christelle , Berthoz Sylvie , Hanachi Mouna , Godart Nathalie 
Published: June 2024

Abstract
Background
Although renal damage is increasingly reported among the most undernourished patients with Anorexia Nervosa (AN), it remains underestimated in current practice, and often associated with acute dehydration. The purpose of our study was to evaluate the frequency, the extent, and the risk factors of renal involvement among adolescents and adults hospitalized in specialized units for AN.

Methods
In this multi-center study, 197 consecutive participants were included, aged 13–65, from 11 inpatient eating disorder psychiatric units. Information on the course of AN, clinical characteristics, biological data, and medication were collected.

Results
At admission, mean BMI was 13.1 (± 1.6) kg/m2 for a mean age of 20.74 (± 6.5) years and the z-score was − 3.6 (± 1.33). Six participants (3.0%) had hyponatremia, four (2.0%) had hypokalemia, and nine (4.5%) had hypochloremia. The Blood Urea Nitrogen/Creatinine ratio was over 20 for 21 (10.6%) participants. The mean plasma creatinine was 65.22 (± 12.8) µmol/L, and the mean eGFR was 74.74 (± 18.9) ml/min. Thirty- five participants (17.8%) had an eGFR > 90 ml/min, 123 (62.4%) from 60 to 90 ml/min, 35 (17.8%) from 45 to 60 ml/min, and 4 (2%) under 45 ml/min. In multivariate analysis, only BMI on admission was a determinant of renal impairment. The lower the BMI the more severe was the renal impairment.

Conclusion
When eGFR is calculated, it highlights renal dysfunction found in severe AN requiring hospitalisation in specialized units. The severity of undernutrition is an independent associated factor. Kidney functionality tests using eGFR, in addition to creatinine alone, should be part of routine care for patients with AN to detect underlying renal dysfunction.
Concussion history associated with adolescent psychological distress but not hazardous gambling: a cross-sectional study
Authors: Andersson Mitchell J. , Kapetanovic Sabina , Håkansson Anders , Claesdotter-Knutsson Emma 
Published: June 2024

Abstract
Background
Sustaining multiple concussions over one’s lifetime may be associated with behavioral and mood changes beyond the acute phase of injury. The present cross-sectional study examined the relationship between concussion history, the incidence of current moderate-severe psychological distress, and lifetime adolescent hazardous gambling in high school students.

Methods
Four-hundred fifty-nine high school students from southern Sweden (age: 16.81 ± 0.83, 58.2% male) completed a survey assessing concussion history (0,1,2…>8), psychological distress using the Kessler-6 scale, and lifetime hazardous gambling using the NODS-CLiP scale.

Results
Participants who self-reported three or more concussions were more likely to endorse moderate-severe symptoms of psychological distress than those with no concussion history while controlling for covariates, OR = 2.71, 95% CI [1.19, 6.18]. In contrast, concussion history was not associated with hazardous gambling after controlling for confounding variables.

Conclusions
Self-reporting three or more concussions was associated with increased current psychological distress beyond the acute phase of injury among high school students. Adolescents who have sustained multiple concussions should undergo mental health evaluations beyond the acute phase of injury to identify and treat psychological distress, but probing for hazardous gambling may not be clinically relevant in this previously concussed adolescent population.
Integrating the ESM usage and work engagement for employee agility performance: based on regulatory focus theory
Authors: Bao Yilinna , Zhu Ye , Kanwal Shamsa , Ullah Ubaid 
Published: June 2024

AbstractThis present research aims to clarify the intricate conjunction of enterprise social media (ESM) utilization and employee agility with a main focus on uncovering the underlying mechanisms that work through the mediating influence of work engagement and the moderating influence of regulatory focus. Drawing upon regularity focus theory, 353 Chinese samples of ESM users in organizational contexts are analyzed using SPSS 23.0. The empirical findings substantiate a robust and significant positive linkage between ESM usage and worker agility. Further reinforcing the model, the mediating role of work engagement is established as it channels the impact of ESM usage on worker agility. Turning to the moderating effects, the study unveils the differential impact of prevention focus and promotion focus, wherein individuals with a lower prevention focus exhibit a more pronounced positive linkage between ESM usage and worker agility. Similarly, individuals with a higher promotion focus demonstrate a heightened positive association between ESM usage and worker agility. By comprehensively inspecting the intricate dynamics of ESM usage, work engagement, and regulatory focus, this study enhances our theoretical understanding of how these factors synergistically shape employee agility, ultimately furnishing organizations with invaluable insights to foster and cultivate an agile workforce.
Large language models and medical education: a paradigm shift in educator roles
Authors: Li Zhui , Li Fenghe , Fu Qining , Wang Xuehu , Liu Hong , Zhao Yu , Ren Wei 
Published: June 2024

AbstractThis article meticulously examines the transformation of educator roles in medical education against the backdrop of emerging large language models (LLMs). Traditionally, educators have played a crucial role in transmitting knowledge, training skills, and evaluating educational outcomes. However, the advent of LLMs such as Chat Generative Pre-trained Transformer-4 has expanded and enriched these traditional roles by leveraging opportunities to enhance teaching efficiency, foster personalised learning, and optimise resource allocation. This has imbued traditional medical educator roles with new connotations. Concurrently, LLMs present challenges to medical education, such as ensuring the accuracy of information, reducing bias, minimizing student over-reliance, preventing patient privacy exposure and safeguarding data security, enhancing the cultivation of empathy, and maintaining academic integrity. In response, educators are called to adopt new roles including experts of information management, navigators of learning, guardians of academic integrity, and defenders of clinical practice. The article emphasises the enriched connotations and attributes of the medical teacher's role, underscoring their irreplaceable value in the AI-driven evolution of medical education. Educators are portrayed not just as users of advanced technology, but also as custodians of the essence of medical education.
Potential for tsunami detection via CCTV cameras in northeastern Toyama Prefecture, Japan, following the 2024 Noto Peninsula earthquake
Authors: Shirai Tomoki , Enomoto Yota , Haga Keisuke , Tokuta Tatsuhiko , Arikawa Taro , Mori Nobuhito , Imamura Fumihiko 
Published: June 2024

AbstractThis study explored closed-circuit television (CCTV) networks in northeastern Toyama Prefecture, Japan, as a new data source for tsunami detection following the 2024 Noto Peninsula earthquake. We analyzed CCTV footage and extracted time-series water level fluctuations at Yokoyama, Shimoiino, and Ekko. Spectral analysis of these waveforms revealed several long-period peaks (more than 100 s) in power spectral density (PSD), suggesting the presence of tsunami components. Notably, relatively large PSD peaks at approximately 5–10 min were observed at all CCTV locations in this study and at offshore wave observation points (Tanaka and Toyama). At Yokoyama, a maximum run-up of approximately 3 m was confirmed around 16:28. Although water level fluctuations at Shimoiino and Ekko were detected, identifying tsunami components proved challenging due to their small magnitude compared to other wave components. Despite these challenges, this study demonstrates the potential of CCTV networks for tsunami detection, and further research is needed to achieve real-time detection.
Incorporation of canola meal as a sustainable natural filler in PLA foams
Authors: Weal Stephanie , Shah Samir , Parker Kate , Vaidya Alankar 
Published: June 2024

AbstractThe canola oil industry generates significant waste as canola meal (CM) which has limited scope and applications. This study demonstrates the possibility of valorization of CM as a sustainable natural filler in a biodegradable polymer composite of Poly(lactic acid) (PLA). Generally, interfacial bonding between natural fibers and the polymer matrix in the composite is weak and non-uniform. One possible solution is to derivatize natural fibre to introduce interfacial bond strength and compatibility with the PLA polymer matrix. Here, CM was succinylated in a reactive extrusion process using succinic anhydride at 30 wt% to get 14% derivatization with 0.02 g of -COOH density per g of CM. The CM or succinylated CM at 5 and 15 wt% was co-extruded with amorphous PLA to get composite fibers. CM-PLA and succinylated CM-PLA biocomposites were foamed using a mild and green microcellular foaming process, with CO2 as an impregnating agent without any addition of organic solvents. The properties of the foams were analyzed using differential scanning calorimetry (DSC), Dynamic mechanical thermal analysis (DMTA), shrinkage, and imaging. The addition of CM or succinylated CM as a natural filler did not significantly change the glass transition temperature, melting point, percent crystallization, stiffness, and thermal stability of PLA foams. This suggests succinylation (modification) of CM is not a mandatory step for improving interphase compatibility with the amorphous PLA. The new PLA-CM foams can be a good alternative in the packaging industry replacing the existing petroleum-based polymer foams.
Graphical Abstract
Effects of Stretching or Strengthening Exercise on Spinal and Lumbopelvic Posture: A Systematic Review with Meta-Analysis
Authors: Warneke Konstantin , Lohmann Lars Hubertus , Wilke Jan 
Published: June 2024

Abstract
Background
Abnormal posture (e.g. loss of lordosis) has been associated with the occurrence of musculoskeletal pain. Stretching tight muscles while strengthening the antagonists represents the most common method to treat the assumed muscle imbalance. However, despite its high popularity, there is no quantitative synthesis of the available evidence examining the effectiveness of the stretch-and-strengthen approach.

Methods
A systematic review with meta-analysis was conducted, searching PubMed, Web of Science and Google Scholar. We included controlled clinical trials investigating the effects of stretching or strengthening on spinal and lumbopelvic posture (e.g., pelvic tilt, lumbar lordosis, thoracic kyphosis, head tilt) in healthy individuals. Effect sizes were pooled using robust variance estimation. To rate the certainty about the evidence, the GRADE approach was applied.

Results
A total of 23 studies with 969 participants were identified. Neither acute (d = 0.01, p = 0.97) nor chronic stretching (d=-0.19, p = 0.16) had an impact on posture. Chronic strengthening was associated with large improvements (d=-0.83, p = 0.01), but no study examined acute effects. Strengthening was superior (d = 0.81, p = 0.004) to stretching. Sub-analyses found strengthening to be effective in the thoracic and cervical spine (d=-1.04, p = 0.005) but not in the lumbar and lumbopelvic region (d=-0.23, p = 0.25). Stretching was ineffective in all locations (p > 0.05).

Conclusion
Moderate-certainty evidence does not support the use of stretching as a treatment of muscle imbalance. In contrast, therapists should focus on strengthening programs targeting weakened muscles.
A one-man bilingual cocktail party: linguistic and non-linguistic effects on bilinguals’ speech recognition in Mandarin and English
Authors: Smith Erin D. , Holt Lori L. , Dick Frederic 
Published: June 2024

AbstractMultilingual speakers can find speech recognition in everyday environments like restaurants and open-plan offices particularly challenging. In a world where speaking multiple languages is increasingly common, effective clinical and educational interventions will require a better understanding of how factors like multilingual contexts and listeners’ language proficiency interact with adverse listening environments. For example, word and phrase recognition is facilitated when competing voices speak different languages. Is this due to a “release from masking” from lower-level acoustic differences between languages and talkers, or higher-level cognitive and linguistic factors? To address this question, we created a “one-man bilingual cocktail party” selective attention task using English and Mandarin speech from one bilingual talker to reduce low-level acoustic cues. In Experiment 1, 58 listeners more accurately recognized English targets when distracting speech was Mandarin compared to English. Bilingual Mandarin–English listeners experienced significantly more interference and intrusions from the Mandarin distractor than did English listeners, exacerbated by challenging target-to-masker ratios. In Experiment 2, 29 Mandarin–English bilingual listeners exhibited linguistic release from masking in both languages. Bilinguals experienced greater release from masking when attending to English, confirming an influence of linguistic knowledge on the “cocktail party” paradigm that is separate from primarily energetic masking effects. Effects of higher-order language processing and expertise emerge only in the most demanding target-to-masker contexts. The “one-man bilingual cocktail party” establishes a useful tool for future investigations and characterization of communication challenges in the large and growing worldwide community of Mandarin–English bilinguals.
Back to the future: the novel art of digital auscultation applied in a prospective observational study of critically ill Covid-19 patients
Authors: Kaimakamis Evangelos , Kotoulas Serafeim , Tzimou Myrto , Karachristos Christos , Giannaki Chrysavgi , Kilintzis Vassileios , Stefanopoulos Leandros , Chatzis Evangelos , Beredimas Nikolaos , Rocha Bruno , Pessoa Diogo , Paiva Rui Pedro , Maglaveras Nicos , Bitzani Militsa 
Published: June 2024

Abstract
Background
The Covid-19 pandemic has caused immense pressure on Intensive Care Units (ICU). In patients with severe ARDS due to Covid-19, respiratory mechanics are important for determining the severity of lung damage. Lung auscultation could not be used during the pandemic despite its merit. The main objective of this study was to investigate associations between lung auscultatory sound features and lung mechanical properties, length of stay (LOS) and survival, in adults with severe Covid-19 ARDS.

Methods
Consecutive patients admitted to a large ICU between 2020 and 2021 (n = 173) were included. Digital stethoscopes obtained auscultatory sounds and stored them in an on-line database for replay and further processing using advanced AI techniques. Correlation and regression analysis explored relationships between digital auscultation findings and lung mechanics or the ICU outcome. The resulting annotated lung sounds database is also publicly available as supplementary material.

Results
The presence of squawks was associated with the ICU LOS, outcome and 90-day mortality. Other features (age, SOFA score & oxygenation index upon admission, minimum crackle entropy) had significant impact on outcome. Additional features affecting the 90-d survival were age and mean crackle entropy. Multivariate logistic regression showed that survival was affected by age, baseline SOFA, baseline oxygenation index and minimum crackle entropy.

Conclusions
Respiratory mechanics were associated with various adventitious sounds, whereas the lung sound analytics and the presence of certain adventitious sounds correlated with the ICU outcome and the 90-d survival. Spectral features of crackles sounds can serve as prognostic factors for survival, highlighting the importance of digital auscultation.
Comparative study on clinicopathological characteristics of functional and non-functional subtypes in pituitary adenomas
Authors: Singh Ashish Ranjan , Kumar Prabhat 
Published: June 2024

Abstract
Background
Pituitary adenomas comprise clinical and pathological characteristics of functional and non-functional subtypes. To enhance our understanding of diagnostic presentations, our study aimed to know the clinicopathological characteristics of pituitary adenomas of both functional and non-functional subtypes. The purpose of our study was to investigate the clinicopathological characteristics of pituitary adenomas, including demographic characteristics, clinical presentations, hormone secretion patterns, invasiveness, and cellular characteristics.

Methods
A total of 41 cases of pituitary adenomas were analyzed, with 63.4% classified as non-functional adenomas (NFPA) and 36.6% as functional adenomas (FPA). Clinical presentations vary, with vision loss and headaches commonly occurring in both NFPA and FPA. In FPAs, serum hormone levels varied and were categorized into growth hormone-secreting (53.3%), ACTH-secreting (26.7%), PRL-secreting (13.3%), and FSH-secreting (6.7%) subtypes. Moreover, clinical presentations in FPA included diplopia, giddiness, vomiting, ptosis, and limb weakness. Clinical features varied across subtypes, with acromegaly in growth hormone-secreting adenomas, moon facies and weight gain in ACTH-secreting adenomas, poor facial growth in PRL-secreting adenomas, and vision loss in FSH-secreting adenomas. Meanwhile, NFPA were predominantly macroadenomas (88.5%) and exhibited various morphological patterns.

Results
The proliferation index is higher in functional adenomas (mean 1.32) as compared to non-functional (mean 0.91). Clinical presentations varied across functional and non-functional adenomas. Growth hormone-secreting adenomas were the most common functional subtype, while LH and null cell adenomas were common non-functional subtypes. Two cases were invasive adenomas with a low Ki67 index. Sheets were the most common morphological pattern. PCA analysis revealed significant differences between the two groups, with PC 1 explaining 92.111% of the variance.

Conclusions
Our study elucidates the clinicopathological characteristics of pituitary adenomas, highlighting significant differences between functional and non-functional subtypes. These findings underscore the importance of tailored diagnostic and management strategies to optimize outcomes for patients with pituitary adenomas.
Honey: an important nutrient and adjuvant for maintenance of health and management of diseases
Authors: Kumar Deepak , Hazra Kalyan , Prasad Peyyala Venkata Vara , Bulleddu Rajesh 
Published: June 2024

AbstractHoney got its significance, both as medical and non-medical purposes. Honey is a complex matrix of several carbohydrates, amino acids, minerals and many more. Honey's carbohydrate components include a variety of mono- and disaccharide forms such as fructose, glucose, sucrose and other reducing sugars. Proline, lysine, phenylalanine, β-alanine, arginine, serine, glutamic acid and aspartic acid are the main amino acids that are present in honey. Immense nutritional benefits make honey a high demanding item in food and in medical. It is a multivitamin tonic enriched with the antimicrobial, antioxidant, cough preventing, hepato-protective, wound healing and immune modulating properties. Being a high demand item, most of the honeys available in market are adulterated by several means. Eventually, human practices developed a number of ways for detection of adulteration in honey. Even modern instrumentation like NMR is becoming a powerful and reliable tool in detection of high-rising adulteration. The present article aims to highlight a thorough of review of medicinal applications of honey with special emphasis on the traditional practices along with an overview of the history, composition, physical and nutritional properties and testing of adulteration.
Reducing edge loading and alignment outliers with image-free robotic-assisted unicompartmental knee arthroplasty: a case controlled study
Authors: Lau Wai Hong , Liu Wai Kiu Thomas , Chiu Kwong Yuen , Cheung Man Hong , Cheung Amy , Chan Ping Keung , Chan Vincent Wai Kwan , Fu Henry 
Published: June 2024

Abstract
Background
Survivorship of medial unicompartmental knee arthroplasty (UKA) is technique-dependent. Correct femoral-tibial component positioning associates with improved survivorship. Image-free robotic-assisted unicompartmental knee arthroplasty enables preoperative and intraoperative planning of alignment and assessment of positioning prior to execution. This study aimed to compare the radiological outcomes between robotic-assisted UKA (R-UKA) and conventional UKA (C-UKA).

Methods
This retrospective case control study involved 140 UKA (82 C-UKA and 58 R-UKA) performed at an academic institution between March 2016 to November 2020, with a mean follow-up of 3 years. Postoperative radiographs were evaluated for mechanical axis and femoral-tibial component position. Component position was measured by two methods: (1) femoral-tibial component contact point with reference to four medial-to-lateral quadrants of the tibial tray and (2) femoral-tibial component contact point deviation from the center of the tibial tray as a percentage of the tibial tray width. Baseline demographics and complications were recorded.

Results
There was a higher mean component deviation in C-UKA compared with R-UKA using method 2 (17.2% vs. 12.8%; P = 0.007), but no difference in proportion of zonal outliers using method 1 (4 outliers in C-UKA, 5.1% vs. 1 outlier in R-UKA, 1.8%; P = 0.403). R-UKA showed no difference in mean mechanical alignment (C-UKA 5° vs. R-UKA 5°; P = 0.250). 2-year survivorship was 99% for C-UKA and 97% for R-UKA. Mean operative time was 18 min longer for R-UKA (P < 0.001).

Conclusion
Image-free robotic-assisted UKA had improved component medio-lateral alignment compared with conventional technique.