bluuebunny/crossref_metadata_2025_split huggingface dataset:
New finger reconstruction technologies using 3D printing
Authors: Aleksandrov N. M. , Veshaev I. D. 
Published: June 2024

Introduction The use of 3D printing technology in finger reconstruction improves accuracy of the procedure minimizing the donor defect and optimizing the appearance and function of the finger. The use of this technology in the finger reconstruction with an osteocutaneous radial forearm flap with axial blood supply and lengthening of the digital stumps and metacarpals remains poorly explored.The objective of the study was to demonstrate new methods of preoperative planning for finger reconstruction and improve surgical outcomes.Material and methods Outcomes of five patients treated with original methods based on 3D technology were retrospectively evaluated during preoperative planning, reconstruction of the thumb using an osteocutaneous radial forearm flap with axial blood supply, relocation of the stump of the third finger and lengthening of the stumps of the first and second metacarpals. The patients could achieve consolidation of interpositional bone allografts following lengthening of the finger stumps, stability of the bone base of the finger, organotypic restructuring of the marginal allograft during plastic surgery with an osteocutaneous radial forearm flap, and a functional position of the reconstructed thumb using the middle finger stump.Results and discussion An individual device for planning finger reconstruction allows identification of the optimal size and position of the finger in three planes, which is essential for patients with severe hand deformities to avoid corrective procedures. An individual guide was used to osteotomize the radius to harvest a vascularized graft providing a cutout of a given size and shape and a cortical-cancellous allograft being identical in shape and size to replace the donor bone defect. The combined use of Masquelet technology and distraction of the finger stump or a metacarpal improved conditions for consolidation and restructuring of the interpositional allograft preventing fractures and infection.Conclusion The use of 3D technology in finger reconstruction using an osteocutaneous radial forearm flap with axial blood supply and distraction of the finger stumps and metacarpals can improve surgical outcomes.
Exploring the Efficacy of Student Community Service Programs (KKN) in Higher Education Institutions: A Case Study in Indonesia
Authors: Hesti Miranda , Markos Valeria 
Published: June 2024

Every university student in higher education is required to take part in Kuliah Kerja Nyata, what is a study service program, according to the curriculum in higher education in Indonesia. Kuliah Kerja Nyata (KKN) was appeared in a decree from the Department of Higher Education for the first time in 1973 (Kisnawat, 2009). In this study we present the origin of Kuliah Kerja Nyata and its policies implemented in the university, a description of Kuliah Kerja Nyata appeared on the universities’s websites, such as the University of Gajah Mada and Bandung Institute of Technology's website, and the benefits of its implementation for the stakeholders. This publication aims to review community service programs and promote community service in higher education. We present a synthetic literature review related to student community service. This publication offer how the Kuliah Kerja Nyata program has been effectively implemented in indonesian universities for students and lecturers.
ЗАСОБИ ТА МЕТОДИ АВТОМАТИЗАЦІЇ КОНТРОЛЮ АНТРОПОМЕТРИЧНИХ ПОКАЗНИКІВ ДІТЕЙ В ЛІКАРСЬКІЙ ПРАКТИЦІ
Authors: Вовянко Світлана , Козяр Василь , Колбасін Максим 
Published: June 2024

Мета роботи: Аналіз засобів та методів автоматизації контролю антропометричних показників дітей, що можуть бути використані у лікарській практиці, для створення додатку із застосуванням автоматизованих засобів збору, збереження, аналізу і оцінки антропометричних показників для своєчасної корекції відхилень шляхом надання індивідуальних рекомендацій. Актуальність: Розрахунок антропометричних даних дитини включає в себе значну кількість показників. Лікар повинен проводити заміри до 20 відповідних показників та вести їх статистичний контроль, для кожної дитини індивідуально. Але, як показує практика, ця методика є досить складною та вимагає витрат великої кількості робочого часу. Тому автоматизація покликана зробити контролюючу та лікувальну методики більш ефективними. Новизна: Разом з оглядом наявних методах контролю антропометричних даних ми пропонуємо автоматизацію процесу контролю нутрієнтів, які споживає дитина під час харчування. Як метод корекції відхилень, згідно з наказом №1073 від 03.09.2017, ефективно використовують індивідуалізовану дієтотерапію з налаштуванням згідно вікових норм. Розробка та створення спеціальної інформаційно-комунікативної медичної системи здатна суттєво спростити роботу лікаря. Спеціаліст буде мати змогу проводити контроль за допомогою будь якого девайсу: телефону, комп’ютера, ноутбука. Це важливо в наших реаліях, адже не завжди лікар буде мати доступ до сучасних пристроїв, але майже кожен має смартфон. Саме тому під час розробки програмного застосунку, треба взяти до уваги програмне середовище, яке має давати змогу без зміни початкового коду, запускати програми на різних операційних системах. Здебільшого в дитячому віці проблему становить зайва маса дитини, що є причиною великої кількості соматичних захворювань. Розрахунковий модуль для батьків може бути дієвим і зручним інструментом вибору нутрієнтів, які необхідні дитині для нормального розвитку. Так само, розрахунковий модуль, батьки зможуть запускати з власного смартфону та проводити розрахунок нутрієнтів для своєї дитини. Це набагато зручніше, враховуючи, що в цьому модулі буде блок корекції, де лікар зможе змінювати норму кількості білків, жирів та вуглеводів, які треба спожити. Результати цього дослідження допоможуть не тільки виявити можливості впровадження передових технологій у медичну практику для моніторингу здоров'я дітей, а й визначити перспективні напрямки майбутніх досліджень у цій сфері.
Novel Dual Bicolumnar Fibula Graft Reconstruction of Distal Humerus in Pediatric Patients After Massive Bone Resection
Authors: Mustafa Mohamed Abdel Rahman , Lam Aaron , Rodriguez Ariel N. , El Masry Ayman Mohammad , Azmy Sherif Ishak , Abdel Aal Maghrabi Mohamed , Abdelgawad Amr Atef 
Published: June 2024

Case:
We describe 2 case studies, involving a 10-year-old girl with an aneurysmal bone cyst and a 12-year-old adolescent boy with Ewing sarcoma. The patient with Ewing sarcoma was previously managed with wide surgical excision and fibular graft reconstruction and subsequently experienced significant graft resorption, hardware failure, and fracture 24 months after operation. A revision limb salvage attempt was undertaken. In both cases, fibular strut grafts were harvested and fixed with intramedullary k-wires to recreate the medial and lateral columns of the distal humeral triangle.

Conclusion:
The technique achieved complete osseous integration, structural support, and functional restoration of the elbow in both cases, with good functional outcomes.
Proximal Tibia Fracture Through Suture Augmentation Sites Following ACL/MCL Repairs
Authors: Feeley Scott M. , Kamali Arash , Colantonio Donald F. , Renninger Christopher H. 
Published: June 2024

Case:
A 35-year-old man sustained a proximal tibia fracture from a low-energy mechanism 1 year after anterior cruciate and medial collateral ligament repairs with suture augmentation (SA). The fracture propagated through both tibial SA anchor sites. Following intramedullary tibial nailing, he returned to his prior level of function.

Conclusion:
While complications of SA for ligamentous procedures are rare, these techniques are being implemented more frequently and the full complication profile is yet to be determined. Our report documents a new complication and potential risk factors that surgeons should consider when performing SA for multiligament knee surgery in active individuals.
Adsorption, Kinetic and Thermodynamic Studies for the Adsorption of Cadmium onto Combination of Chitosan and Coffee Ground Activated Carbon
Authors: Nurhidayanti Nisa , Riyadi Agus 
Published: June 2024

The presence of cadmium in water due to its natural mobility can cause the nature of the water to become toxic and threaten the surrounding ecosystem when it accumulates in the food chain. The aim of this study was to investigate the maximum adsorption capacity using an isothermal model, to determine the rate of adsorption kinetics using chitosan and coffee powder adsorbents in reducing cadmium concentrations in industrial wastewater, and to investigate its thermodynamic magnitude. The research method was applied with laboratory experiments followed by quantitative data analysis to determine the isothermal model and adsorption kinetics. The results showed that the adsorption isotherm follows the Langmuir isotherm model with a correlation coefficient of 0.9970 and a maximum adsorption capacity of 0.7546 mg.g-1, which indicates that the chemical adsorption occurs in a monolayer, where the adsorption sites are homogeneously distributed with the adsorption energy. Permanent and negligible interactions between cadmium molecules (adsorbate) and adsorbent. Thus the pseudo second order kinetic model is a better way to explain the reaction rate for cadmium in combination chitosan and coffee ground activated carbon. Negative ΔGo values indicate that the adsorption reaction takes place spontaneously, ΔHo of 0.3467 indicates an endothermic reaction, and ΔSo of 3.5296 indicates an increase in the randomness of the adsorption process at the adsorbent interface and cadmium during adsorption.
Patch and matrix striatonigral neurons differentially regulate locomotion
Authors: Cai Huaibin , Dong Jie , Wang Lupeng , Sullivan Breanna , sun lixin , Chang Lisa , Smith Victor Martinez , Ding Jinhui , Le Weidong , Gerfen Charles 
Published: June 2024

Abstract

The striatonigral neurons are known to promote locomotion1,2. These neurons reside in both the patch (also known as striosome) and matrix compartments of the dorsal striatum 3-5. However, the specific contribution of patch and matrix striatonigral neurons to locomotion remain largely unexplored. Using molecular identifier Kringle-Containing Protein Marking the Eye and the Nose (Kremen1) and Calbidin (Calb1) 6, we showed in mouse models that patch and matrix striatonigral neurons exert opposite influence on locomotion. While a reduction in neuronal activity in matrix striatonigral neurons precedes the cessation of locomotion, fiber photometry recording during self-paced movement revealed an unexpected increase of patch striatonigral neuron activity, indicating an inhibitory function. Indeed, optogenetic activation of patch striatonigral neurons suppressed locomotion, contrasting with the locomotion-promoting effect of matrix striatonigral neurons. Consistently, patch striatonigral neuron activation markedly inhibited dopamine release, whereas matrix striatonigral neuron activation initially promoted dopamine release. Moreover, the genetic deletion of inhibitory GABA-B receptor Gabbr1 in Aldehyde dehydrogenase 1A1-positive (ALDH1A1+) nigrostriatal dopaminergic neurons (DANs) completely abolished the locomotion-suppressing effect caused by activating patch striatonigral neurons. Together, our findings unravel a compartment-specific mechanism governing locomotion in the dorsal striatum, where patch striatonigral neurons suppress locomotion by inhibiting the activity of ALDH1A1+ nigrostriatal DANs.
Effects of Atorvastatin and Gemfibrozil on Mice Corpus Cavernosum, in vitro
Authors: erkoseoglu ilknur , Duman Mine Kadıoglu , Kesim Sabri , Yaris Ersin , Kalyoncu Nuri 
Published: June 2024

Abstract

Most of the drugs used in the treatment of cardiovascular diseases cause unfavourable effects on erectile functions. In this study, the effect of atorvastatin and gemfibrozil, which has different hypolipidemic mechanisms of action, on the erectile functions observed in mouse corpus cavernosum tissues are evaluatedin vitro. Mouse corpus cavernosum tissues are dissected under ketamine and xylazine anesthesia. Vessels were suspended in 30 ml organ baths filled with Krebs solution and aerated with carbogen (95% O2, 5% CO2) at 37°C. A initial tension of 500 mg was applied to the suspended tissue strips. After a stabilisation period of 90 minutes, the protocols were applied to the tissue. Atorvastatin and gemfibrozil showed no direct contractile or relaxant effect on corpus cavernosum tissues. Both drugs caused a dose –dependent relaxation in tissues precontracted with phenylephrine. While the relaxant effect of atorvastatin is inhibited 40% by L-NAME, this relaxations are totally inhibited by atropine. The relaxations caused by gemfibrozil are inhibited both by L-NAME and atropine. No change was observed in responses of the tissues to acethylcholine, nitroprusside and electrical field stimulation when incubated with atorvastatin or gemfibrozil. As a conlusion, both drugs showed similar effects on corpus cavernosum tissues. Atorvastatin and gemfibrozil caused these effects via endothelial nitric oxide. When all the results are evaluated, not only the two drugs showed no unfavorable effects but also may have some beneficial effects on erectile functions.
Flow Clotometry: Measuring Amyloid Microclots in ME/CFS, Long COVID, and Healthy Samples with Imaging Flow Cytometry
Authors: Pretorius Etheresia , Nunes Massimo , pretorius Jan , Kell Douglas 
Published: June 2024

Abstract

Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) has received more attention since the characterization of Long COVID (LC), a condition somewhat similar in symptom presentation and, to some extent, pathophysiological mechanisms. A prominent feature of LC pathology is amyloid, fibrinolysis-resistant fibrin(ogen) fragments, termed microclots. Despite prior identification of microclots in ME/CFS, quantitative analysis has remained challenging due to the reliance on representative micrographs and software processing for estimations. Addressing this gap, the present study uses a cell-free imaging flow cytometry approach, optimized for the quantitative analysis of Thioflavin T-stained microclots, to precisely measure microclot concentration and size distribution across ME/CFS, LC, and healthy cohorts. We refer to our cell-free flow cytometry technique for detecting microclots as 'flow clotometry'. We demonstrate significant microclot prevalence in ME/CFS and LC, with LC patients exhibiting the highest concentration (18- and 3-fold greater than the healthy and ME/CFS groups, respectively). This finding underscores a common pathology across both conditions, emphasizing a dysregulated coagulation system. Moreover, relating to microclot size distribution, the ME/CFS group exhibited a significantly higher prevalence across all area ranges when compared to the controls, but demonstrated a significant difference for only a single area range when compared to the LC group. This suggests a partially overlapping microclot profile in ME/CFS relative to LC, despite the overall higher concentration in the latter. The present study paves the way for prospective clinical application that aims to efficiently detect, measure and treat microclots.
Improvement of deformation stability of Al2O3 moisture-barrier layer by insertion of 4-bipyridine organic monolayers
Authors: Lee Wooin , Cho Sung Min 
Published: June 2024

Abstract

Flexible organic light-emitting diode (OLED) displays are protected from external moisture using an organic-inorganic thin film encapsulation (TFE) structure. The inorganic thin films used in TFE are excellent moisture barriers, but because they are fragile, thick organic thin films must be used together. In this study, 4,4'-bipyridine (4-BP), a small organic molecule, was inserted into the Al2O3 inorganic thin film as monomolecular layers to improve the moisture barrier and flexibility properties of the Al2O3. The 30 nm-thick Al2O3 layer without the 4-BP monomolecular layers cracked after 1,000 repeated bendings at a bending radius of 1 mm, but when these organic molecular layers were introduced, cracking occurred delayed to a radius of 0.7 mm. The effect of improving flexibility due to the introduction of these 4-BP monomolecular layers was verified through optical Ca tests before and after repeated bending and rolling. In this way, it was shown that small organic molecules such as 4-BP can be effectively used to improve the moisture barrier and flexibility properties of TFE for flexible OLED displays.
The Efficiency of Two Different Synthetic Bone Graft Materials on Alveolar Ridge Preservation after tooth extraction: a split-mouth study
Authors: Ozzo Sameer , Kheirallah‬‏ ‪Mouetaz 
Published: June 2024

Abstract

Background
Alveolar Bone loss occurs frequently during the first six months after tooth extraction. Various studies have proposed different methods to reduce as much as possible the atrophy of the alveolar ridge after tooth extraction. Filling the socket with biomaterials after extraction can reduce the resorption of the alveolar ridge. We compared the volumetric resorption rate after the application of HA/β-TCP or synthetic co-polymer polyglycolic - polylactic acid PLGA mixed with blood to prevent socket resorption immediately and after tooth extraction.
Methods
The study was conducted on 24 extraction sockets of impacted mandibular third molars bilaterally, vertically, and completely covered, with a thin bony layer. HA/β-TCP was inserted into 12 of the dental sockets immediately after extraction, and the synthetic polymer PLGA was inserted into 12 of the dental sockets. All sockets were covered completely with a full-thickness envelope flap. Follow-up was performed for one year after extraction, using radiographs and stents for the vertical alveolar ridge measurements.
Results
The mean volume reduction in the HA/β-TCP and PLGA groups was ± 1.23mm and ± 0.1mm, respectively. A minimal alveolar bone height reduction of HA/β-TCP was observed after 9 months, the reduction showed a slight decrease to 0.93mm, while this rate was 0.04mm after 9 months in the PLGA group. Moreover, the bone height was maintained after three months, indicating a good HA/β-TCP graft performance in preserving alveolar bone (1.04mm) while this rate was (0.08mm) for PLGA (Table 1).
Conclusion
The PLGA graft demonstrated adequate safety and efficacy in dental socket preservation following tooth extraction. However, HA/β-TCP causes greater resorption at augmented sites than PLGA, which clinicians should consider during treatment planning.
GIS and Remote sensing based land use land cover change classification map, interlinked with population growth dynamics in Awash River Basin (ARB), Ethiopia.
Authors: Abayneh Tilahun Gebremichael , Ephrem Gebremariam , Hayal Desta 
Published: June 2024

Abstract

Land use land cover change (LULCC) is an imperative factor in global environmental change parallel with population growth and global warming. In many developing countries dynamics of land use land cover is significantly increasing, the main factors can be mentioned are prompt economic, and population growth along with globalization. The study area, Awash River Basin (ARB) faces several major challenges, including land degradation, depletion of water resources, rapid population growth, and urbanization. This paper aimed at analyzing the dynamics and correlation of land-use land cover change and population growth with respect to flood hazards in the study area. GIS and RS geospatial techniques was applied to develop a comprehensive supervised land use classification maps and to analyze LULCC disparities. The overall accuracy for the year 1990, 2000, 2010 and 2020 classification were 94, 97.6, 99 and 96, whereas the kappa coefficients for the same year were 0.92, 0.97, 0.99 and 0.95 respectively. In general, within three decades of time (1990 to 2020) agricultural land declined by 1.3%, in contrary, bare land is declined significantly by 50%, deep water bodies shows reduction by 43%, forest coverage registered positive value of 13.7%, the Wetland class has shown a significant increase of 191%, whereas urban area has been significantly increased to 121% of change rate. Results of Pearson correlation analysis demonstrated negative r value for bare land, deep water bodies, agricultural land, and forest coverage (-0.75, -0.49, -0.28, & -0.25 correspondingly). In contrary, urban area and wetland are correlated positively along with population growth (0.94 & 0.89) respectively. Moreover, estimated land consumption rate (LCR) is 0.29, 0.28, 0.26, and 0.34 in a year of 1990, 2000, 2010, and 2020 respectively. Henceforth, increment of population alongside with built-up area has potentially caused modifications of land use land cover and regularly results in flooding. Considering sustainable nature-based solution to mitigate spontaneous rapid land use change and flood impacts is invaluable.
Six anthropometric indicators and their association with myocardial infarction and death in male Swedish automotive industry workers followed for 28 years
Authors: Ian Lala Joulha , Dimberg Lennart 
Published: June 2024

Abstract

Background: Overweight, Body Mass Index (BMI, kg/m2) 25-30, and obesity (BMI 30+) have historically been associated with risk of myocardial infarction and death.
Several indexes have been introduced to better reflect the abdominal adiposity. The risk for each index does vary in different populations.
This project aimed to determine the correlations between six common different body measurements and their association with cardiovascular disease risk factors, myocardial infarction, and death in middle-aged workers in the Swedish automotive industry.
Methods: In 1993, 1,000 randomly selected Swedish men from the automotive industry were surveyed at a nurse-led health examination. Body measures were recorded together with blood pressure, and a fasting blood test was analyzed. A 28-year follow-up was conducted using the national myocardial infarction register data from the Swedeheart and death data from the Swedish Cause of Death Register. Multiple logistic regression models were used to compare BMI with the other five body measurements. The measure of obesity was calculated for the following risk indexes: Body Mass Index (BMI), Waist Circumference, Waist-to-Height Ratio, Waist-to-Hip Ratio, Sagittal Abdominal Diameter, and Sagittal Abdominal diameter-to-height ratio. Outcomes of accumulated first-time myocardial infarction and death were assessed as odds ratios (OR) between the fourth and first quartiles, before and after adjustment for traditional risk factors.
Results: Data were recorded for 959 men. Significant correlations between the six body measurements were shown. All were also associated with CVD risk factors, myocardial infarction, and death. However, when adjusted for traditional risk factors the association with cardiovascular endpoints almost disappeared. Before adjustment the highest odds ratio with myocardial infarction was calculated for sagittal abdominal diameter to height ratio, OR=3.60; 95% Confidence Interval (CI) 1.78-7.29; p=0.0016. Correspondingly, the highest OR with all-cause death was calculated for the sagittal abdominal diameter, OR=1.85; 95% CI=1.17-2.92; p=0.0117.
The predictive ability measured by Nagelkerke’s R2 was comparable for each measure.
Conclusions: For this population, after adjustment for traditional risk factors, no index was significantly preferred as a risk factor for myocardial infarction or death.