bluuebunny/crossref_metadata_2025_split huggingface dataset:
Linking Customer Interaction and Innovation: The Mediating Role of New Organizational Practices
Authors: Foss Nicolai J. , Laursen Keld , Pedersen Torben 
Published: November 2010

The notion that firms can improve their innovativeness by tapping users and customers for knowledge has become prominent in innovation studies. Similar arguments have been made in the marketing literature. We argue that neither literatures take sufficient account of firm organization. Specifically, firms that attempt to leverage user and customer knowledge in the context of innovation must design an internal organization appropriate to support it. This can be achieved in particular through the use of new organizational practices, notably, intensive vertical and lateral communication, rewarding employees for sharing and acquiring knowledge, and high levels of delegation of decision rights. In this paper, six hypotheses were developed and tested on a data set of 169 Danish firms drawn from a 2001 survey of the 1,000 largest firms in Denmark. A key result is that the link from customer knowledge to innovation is completely mediated by organizational practices.This work is licensed under a Creative Commons Attribution 4.0 International License. You are free to copy, distribute, transmit and adapt this work, but you must attribute this work as “Organization Science. Copyright © 2017 INFORMS. https://doi.org/10.1287/orsc.1100.0584 , used under a Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ .”
Construction of quasi-periodic response solutions
in forced strongly dissipative systems
Authors: Gentile Guido 
Published: November 2010

Abstract.
We consider a class of ordinary differential equations describing
one-dimensional quasi-periodically forced systems in the presence
of large damping. We give a fully constructive proof of the existence
of response solutions, that is quasi-periodic solutions which have
the same frequency vector as the forcing. This requires dealing with
a degenerate implicit function equation: we prove that the latter
has a unique solution, which can be explicitly determined.
As a by-product we obtain an explicit estimate of the
minimal size of the damping coefficient.
Optimizing Clinical Benefits of Bisphosphonates in Cancer Patients with Bone Metastases
Authors: Aapro Matti , Saad Fred , Costa Luis 
Published: November 2010

Abstract
Bisphosphonates are important treatments for bone metastases. Considerations for optimizing the clinical benefits of bisphosphonates include efficacy, compliance, and safety. Several bisphosphonates are approved for clinical use; however, few have demonstrated broad efficacy in the oncology setting and been compared directly in clinical trials. Among patients with bone metastases from breast cancer, the efficacy of approved bisphosphonates was evaluated in a Cochrane review, showing a reduction in the risk of skeletal-related events (SREs) ranging from 8% to 41% compared with placebo. Between-trial comparisons are confounded by inconsistencies in trial design, SRE definition, and endpoint selection. Zoledronic acid has demonstrated clinical benefits beyond those of pamidronate in a head-to-head trial that included patients with breast cancer or multiple myeloma. Compliance and adherence also have effects on treatment efficacy. In a comparison study, the adherence rates with oral bisphosphonates were found to be significantly lower compared with those of intravenous bisphosphonates. The safety profiles of oral and intravenous bisphosphonates differ. Oral bisphosphonates are associated with gastrointestinal side effects, whereas intravenous bisphosphonates have dose- and infusion rate–dependent effects on renal function. Osteonecrosis of the jaw is an uncommon but serious event in patients receiving monthly intravenous bisphosphonates or denosumab. The incidence of this event can be reduced with careful oral hygiene. A positive benefit-risk ratio for bisphosphonates has been established, and ongoing clinical trials will determine whether individualized therapy is possible.
Involvement of Signaling Molecules on Na+/H+ Exchanger-1 Activity in Human Monocytes
Authors: Sarigianni Maria , Tsapas Apostolos , Mikhailidis Dimitri P , Kaloyianni Martha , Koliakos George , Paletas Konstantinos 
Published: November 2010

Background:Sodium/hydrogen exchanger-1 (NHE-1) contributes to maintaining intracellular pH (pHi). We assessed the effect of glucose, insulin, leptin and adrenaline on NHE-1 activity in human monocytesin vitro. These cells play a role in atherogenesis and disturbances in the hormones evaluated are associated with obesity and diabetes.Methods and Results:Monocytes were isolated from 16 healthy obese and 10 lean healthy subjects. NHE-1 activity was estimated by measuring pHi with a fluorescent dye. pHi was assessed pre- and post-incubation with glucose, insulin, leptin and adrenaline. Experiments were repeated after adding a NHE-1 inhibitor (cariporide) or an inhibitor of protein kinase C (PKC), nitric oxide synthase (NOS), nicotinamide adenine dinucleotide phosphate (NADPH) oxidase, phosphoinositide 3-kinases (PI3K) or actin polymerization. Within the whole study population, glucose enhanced NHE-1 activity by a processes involving PKC, NOS, PI3K and actin polymerization (p = 0.0006 to 0.01). Insulin-mediated activation of NHE-1 (p = <0.0001 to 0.02) required the classical isoforms of PKC, NOS, NADPH oxidase and PI3K. Leptin increased NHE-1 activity (p = 0.0004 to 0.04) through the involvement of PKC and actin polymerization. Adrenaline activated NHE-1 (p = <0.0001 to 0.01) by a process involving the classical isoforms of PKC, NOS and actin polymerization. There were also some differences in responses when lean and obese subjects were compared. Incubation with cariporide attenuated the observed increase in NHE-1 activity.Conclusions:Selective inhibition of NHE-1 in monocytes could become a target for drug action in atherosclerotic vascular disease.
Implantable Cardioverter Defibrillator Therapy: A Single Center Experience in Saudi Arabia
Authors: Hersi Ahmad S 
Published: November 2010

Introduction: Internal Cardioverter Defibrillators (ICD) has been shown to decrease mortality in patients such as those with structural heart disease or at high risk of sudden cardiac death. To date there is no data regarding the clinical features, and outcomes of ICD patients in Saudi Arabia. Accordingly, we explored the clinical features and outcomes of ICD therapy among Saudis.

Methods: Patients who had ICD implantation in King Khalid University Hospital from November 2007 until January 2010 were enrolled.

Results: One hundred and eight ICD were implanted between November 2007 and February 2010. The mean age was 58.6±13.2 years. The majority were male 94 (87%), the rate of Diabetes Mellitus (DM) was 58.3%, Hypertension (HTN) was 61.1%, and 63% were smokers. The mean ejection fraction (EF) was 24.5%. Of the 108 patient 90(83.3%) had ICD insertion for primary prevention and 18(16.7%) for secondary prevention. Of the 90 patients who ICD for primary prevention 62 (57.4%) had ischemic cardiomyopathy, 39(36.1%) had dilated cardiomyopathy and 7 (6.5%) had channelopathy. Over a mean follow-up of 18 months 4 (3.7%) died.

Conclusions: Our study describes for the first time patients characteristic and outcomes for ICD therapy in Saudi Arabia. Our patients are younger and have higher prevalence of risk factors that those in Western countries.
DoctorEye: A Clinically Driven Multifunctional Platform, for Accurate Processing of Tumors in Medical Images
Authors: Skounakis Emmanouil , Farmaki Christina , Sakkalis Vangelis , Roniotis Alexandros , Banitsas Konstantinos , Graf Norbert , Marias Konstantinos 
Published: November 2010

This paper presents a novel, open access interactive platform for 3D medical image analysis, simulation and visualization, focusing in oncology images. The platform was developed through constant interaction and feedback from expert clinicians integrating a thorough analysis of their requirements while having an ultimate goal of assisting in accurately delineating tumors. It allows clinicians not only to work with a large number of 3D tomographic datasets but also to efficiently annotate multiple regions of interest in the same session. Manual and semi-automatic segmentation techniques combined with integrated correction tools assist in the quick and refined delineation of tumors while different users can add different components related to oncology such as tumor growth and simulation algorithms for improving therapy planning. The platform has been tested by different users and over large number of heterogeneous tomographic datasets to ensure stability, usability, extensibility and robustness with promising results.

Availability
The platform, a manual and tutorial videos are available at: http://biomodeling.ics.forth.gr.
It is free to use under the GNU General Public License.
Tacrolimus and Cyclosporine Nephrotoxicity in Native Kidneys of Pancreas Transplant Recipients
Authors: Fioretto Paola , Najafian Behzad , Sutherland David E.R. , Mauer Michael 
Published: November 2010

Summary

Background and objectives
Calcineurin inhibitors, while representing advances for solid organ transplantation, have nephrotoxic potential that reduces their net benefit. Tacrolimus has been considered less nephrotoxic than cyclosporine, but direct quantitative comparisons of the changes in renal structure from baseline to follow-up biopsies have not been done. To avoid the pitfalls of renal allograft studies, including rejection and disease recurrence, we compared the development of calcineurin lesions in the native kidneys of 14 tacrolimus– and 12 calcineurin–treated pancreas transplant alone recipients cured of type 1 diabetes.

Design, setting, participants, & measurements
Research renal biopsies obtained before and at 5 years after transplantation were studied using established morphometric methods.

Results
The cyclosporine and tacrolimus groups had, respectively, on average, 33% versus 44% decline in GFR (ns), 27% versus 29% increase in cortical interstitial fractional volume (ns), 245% versus 347% increase in the fractional volume of cortical tubules that were atrophic (ns), and 291% versus 392% increase in the percent of globally sclerotic glomeruli (ns). Arteriolar hyalinosis did not change significantly in either group.

Conclusions
These studies indicate that the nephrotoxic potential of tacrolimus and cyclosporine are equivalent and support the development of strategies to reduce these negative effects.
Psychology Learning and Teaching in Wales
Authors: Upton Dominic , Martin Jesse 
Published: November 2010

A Learning and Teaching Support Network (LTSN) for Psychology sponsored workshop was held in April 2003 to discuss issues related to the research, teaching and learning of psychology in Wales. Representatives of a number of psychology departments from Welsh Higher Education Institutions (HEIs) attended the workshop. This introductory paper presents an overview of the current teaching of psychology in Welsh higher education: the departments, the research being carried out and the unique political context in which Welsh HE currently finds itself. Following this introduction are articles from Enlli Thomas who discusses the problems associated with attempting to teach psychology in Welsh; Paul Sander who reports on the problems associated with teaching increasing numbers of students; Lance Workman who reports on the differing and changing, self-perceptions of old and new university students; and finally Ray Crozier, who presents a study that explores shy students' views on seminars.
Effect of a Preceptor Education Workshop: Part 1. Quantitative Results of a Hospital-Wide Study
Authors: Sandau Kristin E. , Cheng L. Grace , Pan Zhenyu , Gaillard Philippe R. , Hammer LeAnne 
Published: November 2010

Background:
This study examined the hospital-wide effect of a mandatory 8-hour preceptor workshop on preceptors and orientees.

Methods:
A mixed-methods approach (QUAN + qual) with a quasi-experimental design was used to test nurse preceptors' self-reported confidence and comfort (pre- to post-workshop) in five specific roles in addition to the frequency of coaching critical thinking and providing formal feedback. Additionally, survey items compared cross-sectional cohorts of preceptors and orientees pre- to postworkshop. Orientee retention rates were compared for 1 year before and 1 year after the workshop.

Results:

Findings from the QUAN portion of the study are presented. Paired
t
tests showed that preceptors (
n
= 131) reported significantly improved results for confidence and comfort in all five specific preceptor roles measured 3 to 6 months after workshop attendance; coaching of critical thinking was increased, whereas provision of formal feedback was not. Preceptor-reported comfort and confidence were not significantly greater in the cohort who participated in the workshop compared with the noninterventional cohort (
n
= 74). Among orientees, satisfaction with preceptors was not significantly improved for the cohort whose preceptors had attended training (
n
= 53) versus the previous cohort (
n
= 39). Among orientee cohorts, greater confidence in critical thinking skills on completion of orientation occurred only among experienced transfer nurses. Orientees who had three to four preceptors reported the highest composite satisfaction. One year postintervention, significantly more orientees were retained (125 of 132) than in the previous year (82 of 94) (chi-square,
p
< .05).

Conclusion:
Preceptor workshops are effective in preparing experienced nurses to precept new nurses, as measured by self-reported development of preceptors and retention of orientees.

J Contin Educ Nurs
2011;42(3):117–126.
Digital Templating in Primary Total Hip and Knee Arthroplasty
Authors: Levine Brett , Fabi David , Deirmengian Carl 
Published: November 2010

The use of digital radiography is becoming more prevalent in orthopedics. This transition impacts the ability to preoperatively plan for implants in total hip arthroplasty (THA) and total knee arthroplasty (TKA). This article reports on the clinical success of digital templating using the Advanced Case Plan (Stryker Imaging, Flower Mound, Texas) system in primary THA and TKA.
Digital radiographs of 269 consecutive patients undergoing primary THA (93 cases) or TKA (176 cases) were templated using the Advanced Case Plan digital software package. A 25.4-mm metallic sphere was used as a calibrating marker. Anteroposterior hip and lateral knee radiographs were digitally templated preoperatively and compared to the actual size of the implants at the time of surgery. The accuracy of calibrating images using the metallic sphere was validated by measuring the diameter of femoral heads on 25 postoperative hip radiographs. Digital templating was accurate in predicting the correct implant size in 58.5% of THAs and 66% of TKAs. In 93% of THAs and 98.5% of TKAs, preoperative templating was within 1 size of the final implant. There were no cases in which the predicted implant size varied from the final components by >2 sizes. Calibrating the image using the metallic sphere marker was found to be highly accurate, predicting the correct femoral head size within 1.5 mm in all 25 cases (7 hemiarthroplasties and 18 THAs).
Digital templating is an effective means for predicting the size of THA and TKA components, thus remaining a viable option as we transition into the modern era of digital radiography. Future studies will evaluate interobserver reliability and the impact of level of training on templating accuracy.
Rolling‐horizon replenishment: Policies and performance analysis
Authors: Lian Zhaotong , Liu Liming , Zhu Stuart X. 
Published: November 2010

AbstractWe consider a rolling‐horizon (RH) replenishment modeling framework under which a buyer can update demand information and inventory status, modify order quantities committed previously, place an advanced order for a new period at the end of the RH, and move along in time seamlessly. We show that the optimal order policy for the two‐period RH problem is a dual‐threshold type for updating period(s) plus a base‐stock type for the advanced order. We provide analytical formulas and algorithms to compute the optimal thresholds and the optimal base‐stock level exactly. With our analytical results and numerical procedures, we demonstrate the significant value of RH replenishment in matching supplies to demands more closely. We also show that with RH updating (flexibility), the value of additional demand information beyond the RH diminishes quickly. © 2010 Wiley Periodicals, Inc. Naval Research Logistics, 2010
Technical note: Some structural results on acyclic supply chains
Authors: Shi Junmin , Zhao Yao 
Published: November 2010

AbstractWe consider acyclic supply chains under the full backorder assumption and reveal several simple yet unique properties. Most interestingly, we identify conditions for the best dedicated stocking policy to outperform the best shared stocking policy, and for an acyclic supply chain to be decomposable into a simpler network (e.g., tree). We specify ways to decompose them. © 2010 Wiley Periodicals, Inc. Naval Research Logistics, 2010
Mondrian
Authors: Theus Martin 
Published: November 2010

AbstractMondrian is a general‐purpose statistical data‐visualization system [Theus M. Interactive data visualization using Mondrian. J Stat Softw 2003, 7:1–9]. It features outstanding visualization techniques for data of almost any kind, and has its particular strength compared to other tools when working with categorical data, geographical data, and large data sets. Data displays in Mondrian are interactive, i.e., plot parameters may be changed interactively resulting in an instantaneous update of the views. Furthermore, all plots in Mondrian are fully linked, i.e., any case selected or marked in a plot in Mondrian is highlighted in all other linked plots. Mondrian offers interactive queries, which show information of the data objects in any plot. Copyright © 2010 John Wiley & Sons, Inc.This article is categorized under:

Statistical Learning and Exploratory Methods of the Data Sciences > Exploratory Data Analysis
Software for Computational Statistics > Software/Statistical Software
Statistical and Graphical Methods of Data Analysis > Statistical Graphics and Visualization
Changes in soil carbon flux and carbon stock over a rotation of poplar plantations in northwest China
Authors: Zhang Jianbiao , Shangguan Tieliang , Meng Ziqiang 
Published: November 2010

AbstractForest soil is a major component of terrestrial ecosystems for carbon sequestration and plays an important role in the global carbon cycle. Soil carbon flux and soil carbon pools were investigated in a poplar plantation chronosequence over a rotation in northwest China. Based on continuous field observation in 2007, the results showed that mean soil CO2efflux rate was 5.54, 4.81, and 3.93 μmol CO2m−2s−1for stands of 2‐, 8‐, and 15‐year‐old, respectively, during the growing season. Significant differences in soil respiration of three age classes were mainly because soil temperature, carbon allocation, and fine root growth changed greatly with stand age. Multiple regression analysis suggested that soil temperature and fine root biomass in the upper layer could explain 78–85% of the variation in soil respiration. Mineral soil C stock at 0–40 cm depth was 55.77, 55.09, and 58.14 t ha−1in the 2‐, 8‐, and 15‐year‐old stands, respectively. The average rate of soil C sequestration was 0.13 t ha−1year−1following afforestation on former crop lands. Although the plantations had similar management practices and soil types since their establishment, many biotic and abiotic factors such as root biomass and turnover rate, soil condition of the plantations had undergone marked changes at different development stages, which could result in the remarkable differences in soil carbon flux and storage over a rotation. Our results highlight the importance of the development stage within a rotation of poplar plantation in assessment of soil carbon budget.
The Failure of Democratization in Russia: A Comparative Perspective
Authors: Evans Alfred B. 
Published: November 2010

During the 1990s American leaders and many others in the West viewed Russia as the most important test case for a transition to democracy. Today the consensus of scholarly analyses in the West concludes that, if Russia did enter a transition to democracy, that transition was not successful. This article attempts to suggest some of the main lessons about democratization that may be derived from the study of the experience of post-communist Russia, seen in a comparative perspective. The thesis that the first competitive national election after the downfall of an authoritarian regime marks a decisive breakthrough for forces striving for democratization has not proved true for Russia. Yet the withering of democracy and the consolidation of a semi-authoritarian regime followed the period of competitive elections in Russia. In the early and mid-1990s scholars who had specialized in the study of communist regimes warned that the post-communist states would need to carry out radical economic and social changes as well as sweeping political transformation. In Russia, however, the consequences of a corrupted process of privatization of state assets were enormously damaging for the institutionalization of democracy. As was shown in a number of countries in the 1970s and 1980s, a strong civil society can play an important role in a nation's transition to democracy. The barriers to the development of civil society within the Soviet system and the conditions causing weakness in social organizations in post-communist Russia made it easier for members of the elite to subvert reform and guaranteed that there would be fewer restraints on the tendency toward more authoritarian control after 2000. Among post-communist nations, those in which a consensus of most segments of the elite and the public was committed to a radical break with the old system have been much more successful in carrying out marketization and democratization. The combination of historical conditions that had created a strong anti-communist consensus in most of Eastern Europe had not taken shape in Russia. The absence of a fusion of democratization and national liberation in Russia explained the lack of a clear national consensus in favor of political and economic transformation. One of the main lessons from the course of events in Russia from the early 1990s to the present is that change away from one form of authoritarian rule, which usually has been labeled as a transition to democracy, is not irreversible. Some democratic transitions may prove to be shallow, and the changes in post-communist Russia have provided a good example of a shallow transition. The scholarly literature on transitions to democracy that appeared after the early 1980s departed from earlier writings’ emphasis on the growth of social, economic, and cultural conditions for the institutionalization of democracy in the political system. The experience of Russia may encourage us to return to the study of the long-term trends facilitating or inhibiting the growth of democratic institutions.