bluuebunny/crossref_metadata_2025_split huggingface dataset:
Potential pharmacodynamic drug-drug interaction between concomitantly administered lisinopril and diclofenac sodium: a call for appropriate management in hypertensive osteoarthritic patients
Authors: Goswami Sailendra Kumar , Jain Sunita , Chudasama Hiren , Santani Devdas 
Published: October 2011

Abstract

Background: The present study was designed as an open label, multiple-dose, randomized, parallel trial to evaluate the pharmacodynamic drug-drug interaction of lisinopril and concomitantly administered diclofenac sodium in non-diabetic and diabetic, mild to moderate hypertensive, osteoarthritic patients.

Methods: Post-screening and on inclusion, patients were put on a 2-week washout period and then randomly assigned to either only lisinopril 10 mg or combination of lisinopril 10 mg and diclofenac sodium 100 mg treatments for 8–12 weeks in diseased states of hypertension and osteoarthritis with or without type 2 diabetes mellitus.

Results: The blood pressure (BP) control with lisinopril was reduced by concomitantly administered diclofenac sodium in non-diabetic (SBP: p=0.00002; DBP: p=0.000008) and diabetic (SBP: p=0.002; DBP: p=0.001) patients when compared with the patients receiving lisinopril alone. Insulin sensitivity was improved (p=0.00002) and urinary albumin excretion rate was better controlled (p=0.0096) in lisinopril-treated patients when compared with the combination treatment in diabetic pool. Serum creatinine levels increased significantly in non-diabetic patients (p=0.00004) receiving combination treatment. In addition, creatinine clearance (CLCR) and blood urea nitrogen (BUN) were significantly higher in diabetic (CLCR: p<0.00001; BUN: p=0.0098) as well as in non-diabetic (CLCR: p<0.00001; BUN: p=0.03) patients treated with combination treatment. The alterations in serum electrolytes, reduction in % platelet aggregation activity and improvement in lipid profile was more profound with combination treatment in comparison to lisinopril alone.

Conclusions: The antihypertensive efficacy and insulin sensitivity improving property of lisinopril along with the renal function might get worse in hypertensive osteoarthritic patients receiving concomitant treatment of oral diclofenac sodium with lisinopril. In addition to this, close monitoring of serum electrolytes is also suggested to rule out any long-term detrimental effect.
Decreased IRS2 and TIMP3 Expression in Monocytes From Offspring of Type 2 Diabetic Patients Is Correlated With Insulin Resistance and Increased Intima-Media Thickness
Authors: Cardellini Marina , Menghini Rossella , Luzi Alessio , Davato Francesca , Cardolini Iris , D'Alfonso Rossella , Gentileschi Paolo , Rizza Stefano , Marini Maria Adelaide , Porzio Ottavia , Lauro Davide , Sbraccia Paolo , Lauro Renato , Federici Massimo 
Published: October 2011

OBJECTIVE
In humans, it is unclear if insulin resistance at the monocyte level is associated with atherosclerosis in vivo. Here we have studied first-degree relatives of patients with type 2 diabetes to investigate whether a reduction in components of the insulin signal transduction pathways, such as the insulin receptor (InsR) or InsR substrate 1 or 2 (IRS1 or IRS2), or a reduction in genetic modifiers of insulin action, such as the TIMP3/ADAM17 (tissue inhibitor of metalloproteinase 3/A disintegrin and metalloprotease domain 17) pathway, is associated with evidence of atherosclerosis.

RESEARCH DESIGN AND METHODS
Insulin sensitivity was analyzed through euglycemic-hyperinsulinemic clamp, and subclinical atherosclerosis was analyzed through intimal medial thickness. Monocytes were isolated through magnetic cell sorting, and mRNA and proteins were extracted and analyzed by quantitative PCR and pathscan enzyme-linked immunosorbent assays, respectively.

RESULTS
In monocyte cells from human subjects with increased risk for diabetes and atherosclerosis, we found that gene expression, protein levels, and tyrosine phosphorylation of IRS2, but not InsR or IRS1, were decreased. TIMP3 was also reduced, along with insulin resistance, resulting in increased ectodomain shedding activity of the metalloprotease ADAM17.

CONCLUSIONS
Systemic insulin resistance and subclinical atherosclerosis are associated with decreased IRS2 and TIMP3 expression in circulating monocytes.
Urinary Markers of Nucleic Acid Oxidation and Long-Term Mortality of Newly Diagnosed Type 2 Diabetic Patients
Authors: Broedbaek Kasper , Siersma Volkert , Henriksen Trine , Weimann Allan , Petersen Morten , Andersen Jon T. , Jimenez-Solem Espen , Stovgaard Elisabeth S. , Hansen Lars J. , Henriksen Jan Erik , Bonnema Steen J. , de Fine Olivarius Niels , Poulsen Henrik E. 
Published: October 2011

OBJECTIVE
We analyzed data from a cohort of 1,381 newly diagnosed type 2 diabetic patients to test the hypothesis that urinary markers of nucleic acid oxidation are independent predictors of mortality.

RESEARCH DESIGN AND METHODS
We examined the relationship between urinary excretion of markers of DNA oxidation (8-oxo-7,8-dihydro-2′-deoxyguanosine [8-oxodG]) and RNA oxidation (8-oxo-7,8-dihydroguanosine [8-oxoGuo]) and long-term mortality using Cox proportional hazards regression.

RESULTS
After multivariate adjustment, the hazard ratios for all-cause and diabetes-related mortality of patients with 8-oxoGuo levels in the highest quartile compared with those in the lowest quartile were 1.44 (1.12–1.85) and 1.54 (1.13–2.10), respectively. Conversely, no significant associations between 8-oxodG and mortality were found in the adjusted analyses.

CONCLUSIONS
Urinary excretion of the RNA oxidation marker 8-oxoGuo measured shortly after diagnosis of type 2 diabetes predicts long-term mortality independently of conventional risk factors. This finding suggests that 8-oxoGuo could serve as a new clinical biomarker in diabetes.
Severe hiccups associated with intra-articular corticosteroid injection — A case report
Authors: Solun Boris , Ori Yakov 
Published: October 2011

Abstract
A hiccup is a sudden contraction of the inspiratory and diaphragmatic muscles followed by an abrupt closure of the glottis; that produces a characteristic noise resulting from vibrations of the vocal cords. Brief episodes of hiccups are common in humans at all stages of life and are usually benign. Prolonged attacks that last for days or weeks are considered a more serious phenomenon and may indicate an underlying disorder warranting a comprehensive medical evaluation. These attacks have been associated with significant burden and morbidity. The most common triggers for acute hiccups are linked with gastro-intestinal causes, such as the gastric distension that occurs after an abundant meal, or with gastroesophageal disease. Sudden changes in temperature, excessive alcohol consumption, as well as excitement or emotional stress, may also set off acute hiccups. Certain drugs, including benzodiazepines, barbiturates, and many others, have been reported to induce hiccups. Drug-induced hiccups are diagnosed by exclusion of other causes and represent a very unusual side-effect of drugs like corticosteroids. We present a case of hiccups associated with intra-articular Diprospan (Betamethasone Sodium Phosphate) administration.
Somatostatine analogue in nonoperative treatment of posttraumatic pancreatic pseudocyst in a child: a case report
Authors: Marjanovic Vesna , Slavkovic Andjelka , Stojanovic Miroslav , Stefanovic Vladisav , Marjanovic Goran , Jankovic Radmilo 
Published: October 2011

Abstract
Pancreatic pseudocyst is a complication of pancreatic trauma. We describe improved nonoperative treatment of patient with posttraumatic pancreatic pseudocyst with somatostatin analogue. A 9-year-old girl was admitted to our hospital after blunt abdominal trauma with handlebar. Three weeks after abdominal trauma, pancreatic pseudocyst developed. Nonoperative treatment of posttraumatic pancreatic pseudocyst (the largest dimensions 70 × 55 × 65 mm) with somatostatin analogue, octreotide acetate, was applied for the next 52 days. The patient was followed up for 24 months after the discontinuation of octreotide and there were no recurrence of pancreatic pseudocyst. Somatostatin analogue could be usefull in the nonoperative treatment of posttraumatic pancreatic pseudocysts in children.
De Neptune à Pluton : sommes-nous tous des demi-partenaires ?
Authors: Janne Pascal , Tordeurs David 
Published: October 2011

Les difficultés de conjugalisation prennent des formes diverses : célibat mal vécu, donjuanisme, échecs amoureux répétitifs, extraconjugalité, etc. Notre propos est de mettre en évidence le caractère non conjugal de certaines situations cliniques, « recadrables » sur base de logiques de conflits de loyautés et de processus de parentification antérieurs.
Émergence et registre d’action des associations pour le maintien de l’agriculture paysanne (AMAP) en périurbain : quel lien au territoire ?
Authors: Chometon Marianne 
Published: October 2011

L’agriculture dans les espaces périurbains a une place paradoxale : elle est mise en difficulté par le processus d’urbanisation tout en étant garante des aménités qui suscitent l’attrait pour de nouveaux habitants pour les espaces en périphérie des villes. Au travers d’une étude de cas exploratoire, nous avons cherché à comprendre quel rôle joue le territoire dans le processus d’émergence des AMAP dans ces situations périurbaines et comment il s’en trouve transformé dans son organisation spatiale et sociale. L’étude du cas de l’AMAP des Cheires (Auvergne, France) montre que la reconnaissance du capital naturel comme ressource du territoire est un levier de l’action collective menée en vue de sa préservation. Le territoire local est d’abord l’objet des mécanismes de coordination entre les acteurs. Cependant, au fil du temps, les mobilisations collectives se pensent à une échelle plus globale. Les logiques d’action collective relèvent du “ militantisme pragmatique ” dans le sens où ces associations se font reconnaître en tant qu’acteur de l’agriculture au travers des actions concrètes qu’elles mettent en place.
L’atelier « H » ou la représentation de l’adaptation dans l’élaboration du plan climat de Paris
Authors: Simonet Guillaume 
Published: October 2011

L’adaptation aux changements climatiques est une dimension de plus en plus prise en compte dans le domaine aussi bien politique que scientifique, mais sa mise en pratique demeure encore parcellaire. Le cas se présente notamment en milieux urbains des pays riches qui présentent pourtant une forte vulnérabilité face aux aléas climatiques à travers leur densité de population et d’activités économiques. Le Plan Climat de Paris élaboré en 2006 par le biais d’une démarche participative comporte un chapitre sur l’adaptation réalisé à partir du compte-rendu final de l’atelier de travail responsable de traiter ce thème (atelier "H"). L’article présente les résultats de l’étude rétrospective effectuée auprès des organisateurs (municipal et privé) du Plan Climat, des observateurs et des participants présents à l’atelier "H", lesquels montrent la difficulté d’arriver à une représentation collective claire à la fois de la définition de l’adaptation et des enjeux que cela implique lors de sa mise en œuvre dans un milieu urbain comme Paris. Parmi les obstacles principaux à cette compréhension, on retrouve l’émergence de la prise de conscience face à la problématique des changements climatiques, l’ambiguïté sémantique du terme « adaptation » et le chevauchement des notions de mitigation et d’adaptation.
Autoreactive Tbet-Positive CD4 T Cells Develop Independent of Classic Th1 Cytokine Signaling during Experimental Autoimmune Encephalomyelitis
Authors: Yeh Wen-I , McWilliams Ian L. , Harrington Laurie E. 
Published: October 2011

Abstract
Many autoimmune chronic inflammatory diseases, including multiple sclerosis, are associated with the presence of Th1 and Th17 effector CD4 T cells. Paradoxically, the principal Th1 cytokine IFN-γ does not appear necessary for disease, but the key Th1-associated transcription factor Tbet has been reported to be essential for disease development. This conundrum propelled us to investigate the regulation of this transcription factor during autoimmunity. Following the onset of experimental autoimmune encephalomyelitis, we observed a preferential upregulation of Tbet by CD4 T cells within the CNS, but not the secondary lymphoid organs. These Tbet-positive CD4 T cells were capable of producing the cytokine IFN-γ, and a proportion of these cells produced both IFN-γ and IL-17A. Interestingly, these Tbet-positive cells were present in high frequencies during disease in IFN-γ–deficient mice. Moreover, we found that CD4 T cells from IFN-γ–deficient/IFN-γ reporter mice upregulated the Thy1.1 reporter, indicating the presence of Th1 or Th1-like, Tbet-positive CD4 T cells even in the absence of the cardinal Th1 cytokine IFN-γ. These IFN-γ–deficient Th1-like cells not only maintain multiple Th1 properties but also exhibit increased expression of genes associated with the Th17 phenotype. We further examined the requirement of other Th1-associated molecules in controlling Tbet expression during experimental autoimmune encephalomyelitis and noted that STAT1, IL-12, and IFN-γ were dispensable for the induction of Tbet in vivo. Hence, this study highlights the complex regulation of Tbet and the potential unrecognized role for Th1 cells during autoimmunity.
Epidermal CCR6+ γδ T Cells Are Major Producers of IL-22 and IL-17 in a Murine Model of Psoriasiform Dermatitis
Authors: Mabuchi Tomotaka , Takekoshi Tomonori , Hwang Sam T. 
Published: October 2011

Abstract
Cytokine components of Th17 pathway play vital roles in human psoriasis. Although much is known about TCR αβ T cells in psoriasis, the role of unconventional T cells, including γδ T cells, is unclear. In this study, using an IL-23 skin injection model of psoriasiform dermatitis in mice, we demonstrate that IL-22, IL-17A, and the IL-23R were highly enriched in a population of CCR6+, TCR γδ-low expressing (GDL) T cells that accumulated in the epidermis after IL-23 injections. GDL cells were distinct from resident TCR γδ-high, Vγ3+,CCR6− T cells in the epidermis that did not change appreciably in numbers following IL-23 injection. Large numbers of CCR6+ cells were detected at or above the level of the epidermal basement membrane by confocal microscopy 5 d after repeated IL-23 injections at the same time GDL cells increased in numbers in the epidermis. TCR δ-deficient mice (lacking γδ T cells) exhibited decreased ear swelling and downregulated expression of IL-22 and IL-17A in the epidermis following IL-23 injection. Our data suggest that a subset of γδ T cells play a critical role in IL-23–mediated psoriasiform dermatitis.
Demographic concepts and research pertaining to the study of wild primate populations
Authors: Lawler Richard R. 
Published: October 2011

AbstractDemography is the study of individuals as members of a population. The dynamics of a population are determined by collectively analyzing individual schedules of survival, growth, and reproduction. Together, these schedules are known as the vital rates of the population. The vital rates, along with dispersal, contribute to population structure, which refers to how the population is organized by age, sex, density, and social groups. I briefly review the history of anthropological demography as it pertains to wild primates and then I discuss basic demographic concepts and approaches for studying wild primate populations. I then turn to demographic studies of wild primate demography. Primates are generally characterized by high adult survival probabilities relative to survival at other age/stage classes and most primate populations have population growth rates near equilibrium. Changes in adult survival have the greatest impact on population growth rate (i.e., fitness) relative to other demographic traits such as juvenile/yearling survival or age at first reproduction. I discuss how these demographic patterns, and others, connect to topics and issues in behavioral ecology, life history theory, population genetics, and conservation biology. These connections help reaffirm the fact that the vital rates are both targets and agents of evolutionary change. In this regard, demographic studies of wild primates provide a critical link between the proximate socioecological processes that operate in a species and the long‐term phylogenetic patterns that characterize a species. Yrbk Phys Anthropol, 2011. © 2011 Wiley‐Liss, Inc.
Design, Synthesis and Evaluation of Anticonvulsant Activity of Pyridinyl‐Pyrrolidones: A Pharmacophore Hybrid Approach
Authors: Siddiqui Nadeem , Ahsan Waquar , Alam M. Shamsher , Ali Ruhi , Srivastava Kamna 
Published: October 2011

AbstractVarious 1‐[6‐(4‐substituted phenyl)‐3‐cyano‐4‐(substituted phenyl)‐pyridin‐2‐yl]‐5‐oxopyrrolidine‐3‐carboxylic acids (3a–t) were designed and synthesized by clubbing pyrrolidinones and pyridines, the two active anticonvulsant pharmacophores. All the synthesized compounds fulfilled the requirements of suggested pharmacophoric model for anticonvulsant activity. Their in vivo anticonvulsant evaluation was performed by maximal electroshock seizure (MES) and subcutaneous pentylenetetrazole (scPTZ) tests. The minimal motor impairment was assessed by rotorod test and the estimation of various liver enzymes was performed to check the magnitude of liver toxicity posed by the synthesized compounds. Compounds 3d and 3k displayed comparable anticonvulsant activity to the standard drugs with ED50 values of 13.4 and 18.6 mg/kg in electroshock screen, repectively. The compounds 3d and 3k were also found to have encouraging anticonvulsant activity (ED50 = 86.1 and 271.6 mg/kg, respectively) in scPTZ screen. Interestingly, they did not show any sign of motor impairment at the maximum dose administered and were not toxic to the liver.
Metal Oxidation with N2O5: The Nitrosylium Nitrates (NO)Cu(NO3)3, (NO)2[Zn­(NO3)4] and (NO)6[Ni4(NO3)12](NO3)2·(HNO3)
Authors: Gagelmann Steffen , Rieß Katja , Wickleder Mathias S. 
Published: October 2011

AbstractThe oxidation of copper, zinc and nickel by N2O5 led, respectively, to turquoise‐coloured single crystals of (NO)Cu(NO3)3 [monoclinic, P21/m, Z = 2, a = 465.90(5), b = 1111.7(1), c = 700.7(1) pm, β = 100.70(2)°, wR2 = 0.0566], light‐yellow single crystals of (NO)2[Zn(NO3)4] [orthorhombic, Fdd2, Z = 8, a = 1522.8(2), b = 2346.4(3), c = 596.18(7) pm, wR2 = 0.0452] and green single crystals of (NO)6[Ni4(NO3)12](NO3)2·(HNO3) [orthorhombic, P212121, Z = 4, a = 1167.68(4), b = 1791.97(6), c = 1834.11(6) pm, wR2 = 0.0762]. In (NO)Cu(NO3)3, the Cu2+ ion is coordinated by six oxygen atoms of monodentatenitrate groups in the form of a tetragonal distorted octahedron. The nitrate groups are connected to further copper ions leading to a two‐dimensional network. In contrast, in (NO)2[Zn(NO3)4], the nitrate anions are coordinated to only one Zn2+, ion and the coordination polyhedron is a distorted octahedron. The complex nitrate (NO)6[Ni4(NO3)12](NO3)2·(HNO3) exhibits anionic ribbon chains according to ∞1{[Ni(NO3)1/1(NO3)4/2]}22– with octahedrally coordinated Ni2+ ions as well as non‐coordinating nitrate ions and HNO3 molecules. The thermal decomposition of the copper and zinc nitrates are multistep processes and lead to a mixture of Cu and Cu2O in the case of the copper compound and to ZnO for the zinc complex.
Development of a Simple and Fast Electrochemical Method to Evaluate Physical Stress in Athletes
Authors: Bezerra da Silva Rodrigo Amorim , Rodrigues Cunha Rafael , Coelho da Silva Abílio Tomaz , Bessa de Oliveira Artur Luis , Salmen Espindola Foued , Abarza Munoz Rodrigo Alejandro , Richter Eduardo Mathias 
Published: October 2011

AbstractThis work describes a simple and fast electrochemical method to evaluate the level of physical stress in athletes by monitoring total proteins in saliva. The proposed system is based on FIA with multiple pulse amperometric detection (FIA/MPA) using gold as the working electrode and 0.1 mol L−1 NaOH as the unique reagent. The proposed method is economical, fast (110 injections per hour) and allows the analysis of a small amount of saliva (∼32 µL) with no sample treatment (just dilution). The results obtained by FIA/MPA were compared with the reference spectrophotometric method (Bradford) and a good agreement was found (r=0.967; p<0.05). In order to investigate a portable system to determinate physical stress, the electrodes were adapted to a batch injection analysis system (BIA) and the current signals of total proteins in saliva were obtained, similar to FIA.
Human factors and ergonomics in patient safety curriculum
Authors: Williams Linda , Watts Bradley V. , McKnight Scott , Bagian James P. 
Published: October 2011

AbstractThe importance of teaching human factors and ergonomics (HFE) and patient safety is registered in two compelling facts: 1) the numbers of physicians who train in VA hospitals and 2) in the need for hospitals to function as highly reliable organizations. In the United States, more than half of the physicians‐in‐training do at least part of their medical school and residency training at veterans' health care facilities. Health care currently does not measure up to other high‐reliability organizations. By providing a HFE‐based patient safety curriculum, we hope to improve patient safety at the frontlines. We see the lasting benefit as residency programs that produce physicians who are competent, patient safety problem solvers throughout their careers who will assist health care organizations to become highly reliable. © 2011 Wiley Periodicals, Inc.
Four years' experience with a hospitalist‐led medical emergency team: An interrupted time series
Authors: Rothberg Michael B. , Belforti Raquel , Fitzgerald Janice , Friderici Jennifer , Keyes Marjorie 
Published: October 2011

AbstractBACKGROUND:The effect of Medical Emergency Teams (METs) on cardiopulmonary arrests (codes) and fatal codes remains unclear and widely debated.OBJECTIVE:To describe the implementation of a hospitalist‐led MET and compare the number of code calls and code deaths before and after implementation.DESIGN:Interrupted time series.SETTING:Tertiary care academic medical center.PATIENTS:All hospitalized patients.INTERVENTION:Implementation of an MET, consisting of a critical care nurse, respiratory therapist, intravenous therapist, and the patient's physician.MEASUREMENTS:Number of MET calls, code calls, cardiac arrests and other medical crises, and code deaths per 1000 admissions, stratified by location (inside vs outside critical care).RESULTS:From implementation in March 2006 through December 2009, the MET logged 2717 calls, most commonly for respiratory distress (33%), cardiovascular instability (25%), and neurological abnormality (20%). Overall code calls declined significantly between pre‐implementation and post‐implementation of the MET from 7.30 (95% confidence interval [CI] 5.81, 9.16) to 4.21 (95% CI 3.42, 5.18) code calls per 1000 admissions. Outside of critical care, code calls declined from 4.70 (95% CI 3.92, 5.63) before the MET was implemented to 3.11 (95% CI 2.44, 3.97) afterwards, primarily due to a decrease in medical crises, which averaged 3.29 events per 1000 admissions (95% CI 2.70, 4.02) before implementation and decreased to 1.72 (95% CI 1.28, 2.31) afterwards. Code calls within critical care also declined. The rate of fatal codes was not affected.CONCLUSIONS:A hospitalist‐led MET decreased code call rates but did not affect mortality rates. Journal of Hospital Medicine 2012;. © 2011 Society of Hospital Medicine