bluuebunny/crossref_metadata_2025_split huggingface dataset:
A longitudinal study examining the relationship between prioritization scores and changes in impact on life scores in elective surgery patients
Authors: McCombie Andrew , Bothara Roshit , MacCormick Andrew , Carne Brennan , Hercus Alastair , Eglinton Tim 
Published: April 2024

AbstractBackgroundHealthcare systems globally face the issue of resource constraints and need for prioritization of elective surgery. Inclusive, explicit prioritization tools are important in improving consistency and equity of access to surgery across health systems. The General Surgical Prioritization Tool developed by New Zealand's Ministry of Health scores patients for elective non‐cancer surgery based on surgeon's clinical judgement and patient derived Impact on Life (IoL) scores. This study aims to measure the changes in patient derived IoL scores after common general surgical procedures to enable direct comparison and inform future prioritization.MethodThis longitudinal observational study enrolled 322 participants who had undergone elective general surgical procedures. Participants were contacted 3 to 9 months after their procedures and requested to complete the IoL questionnaire. The primary endpoint was the change in IoL scores after surgery among the different procedures.ResultsOverall, 229/304 (75%) participants responded to the questionnaire and there were no significant baseline differences between responders and non‐responders. Patients in the gallbladder treatment group had the greatest improvement in IoL scores. Patients across all ethnic groups had similar changes in IoL scores. Multivariate analysis showed that gallbladder surgery (relative to hernia surgery) and pre‐surgery IoL scores significantly predicted improvement.ConclusionThe patient reported IoL score recorded at prioritization for surgery all reduced, albeit to varying amounts, after common general surgical procedures. This, combined with the fact that IoL scores predicted post‐operative improvement support their inclusion in prioritization tools in addition to surgeon derived components.
Spatial Theory in Planning Practice? On the Concepts of Space that Made Urban Design a Planning Solution for Segregation in Malmö, Sweden
Authors: Pries Johan 
Published: April 2024

AbstractStudying the Sorgenfri urban renewal project in the Swedish city of Malmö, this article suggests that a shift in planning documents reflects a new understanding of segregation containing traces of arguments from theoretical debates in geography. This new understanding of segregation appears informed by geographic debates on encounters, mobility, and boundaries, and implies that segregation is best addressed by planners in public space “between” housing areas to create more “meetings” between “strangers”. While planning focused on segregation in a more granular way, it also ignored racialised inequality's structural preconditions in ways that perfectly match the neoliberal premises of municipal planning. Thus, translating spatial theory into planning practice can be seen as a strategically selective work shaped by local political conditions. This means that geographers’ work might have unexpected and undesired effects even when it has “impact” in policy practice, and that geographers would do well to face this challenge equally strategically.
Conversion of one anastomosis gastric bypass to distal Roux‐en‐Y gastric bypass due to recurrent weight gain and gastroesophageal reflux disease: A video case report
Authors: Kermansaravi Mohammad , Shahabi Shahmiri Shahab , Yarigholi Fahime , Mehraz Arash 
Published: April 2024

AbstractOne‐anastomosis gastric bypass (OAGB) complications include inadequate weight loss, recurrent weight gain (RWG), and gastroesophageal reflux disease (GERD). Conversion to distal Roux‐en‐Y gastric bypass (D‐RYGB) may be an effective conversional approach. A 38‐year‐old female underwent OAGB with a body mass index (BMI) of 53 kg/m2 and 43% initial total weight loss but had RWG to BMI of 44 kg/m2 over 5 years with refractory GERD symptoms. She underwent D‐RYGB conversion, creating a 330 cm biliopancreatic limb, 75 cm Roux limb, and 400 cm total alimentary limb length to decrease the chance of malnutrition. At 2 weeks, GERD symptoms were resolved completely. By 12 months, 42% total weight loss was achieved with normal nutritional parameters. For RWG and refractory GERD after OAGB, conversion to D‐RYGB can promote weight loss and GERD symptom control while preventing nutritional deficiencies.
Physiotherapy for continence and muscle function in prostatectomy: a randomised controlled trial
Authors: Ouchi Mifuka , Kitta Takeya , Chiba Hiroki , Higuchi Madoka , Abe‐Takahashi Yui , Togo Mio , Kusakabe Naohisa , Murai Sachiyo , Kikuchi Hiroshi , Matsumoto Ryuji , Osawa Takahiro , Abe Takashige , Shinohara Nobuo 
Published: April 2024

ObjectiveTo assess the effectiveness of pre‐ and postoperative supervised pelvic floor muscle training (PFMT) on the recovery of continence and pelvic floor muscle (PFM) function after robot‐assisted laparoscopic radical prostatectomy (RARP).Patients and MethodsWe carried out a single‐blind randomised controlled trial involving 54 male patients scheduled to undergo RARP. The intervention group started supervised PFMT 2 months before RARP and continued for 12 months after surgery with a physiotherapist. The control group was given verbal instructions, a brochure about PFMT, and lifestyle advice. The primary outcome was 24‐h pad weight (g) at 3 months after RARP. The secondary outcomes were continence status (assessed by pad use), PFM function, and the Expanded Prostate Cancer Index Composite (EPIC) score.ResultsPatients who participated in supervised PFMT showed significantly improved postoperative urinary incontinence (UI) compared with the control group (5.0 [0.0–908.0] g vs 21.0 [0.0–750.0] g; effect size: 0.34, P = 0.022) at 3 months after RARP based on 24‐h pad weight. A significant improvement was seen in the intervention compared with the control group (65.2% continence [no pad use] vs 31.6% continence, respectively) at 12 months after surgery (effect size: 0.34, P = 0.030). Peak pressure during a maximum voluntary contraction was higher in the intervention group immediately after catheter removal and at 6 months, and a longer duration of sustained contraction was found in the intervention group compared with the control group. We were unable to demonstrate a difference between groups in EPIC scores.ConclusionSupervised PFMT can improve postoperative UI and PFM function after RARP. Further studies are needed to confirm whether intra‐anal pressure reflects PFM function and affects continence status in UI in men who have undergone RARP.
The molecular characteristics of recurrent/metastatic HPV‐positive head and neck squamous cell carcinoma: A systematic review of the literature
Authors: Flach Susanne , Maniam Pavithran , Hey Shi Ying , Manickavasagam Jaiganesh 
Published: April 2024

AbstractObjectivesAbout 17% of patients with human papillomavirus (HPV)‐positive head and neck squamous cell carcinoma (HNSCC), which is mainly comprised of oropharyngeal SCC (OPSCC), will experience disease recurrence, which is often considered incurable when manifested at a metastatic and/or recurrent stage. We conducted a critical qualitative systematic review.Our objectives were to provide an overview of the molecular landscape of recurrent/metastatic HPV‐positive HNSCC as well as novel molecular biomarkers.DesignA literature review was conducted to identify studies reporting on the molecular characteristics of recurrent/metastatic HPV‐positive HNSCC, novel molecular biomarkers and treatment options. The reviews of abstracts, full articles, and revision of the included studies, followed by data extraction and quality assessment were performed by three independent assessors. All primary literature, such as retrospective, prospective, and clinical trials as well as basic research studies were considered, and the final search was conducted at the end of February 2023. The level of evidence was rated using the guidelines published by the Oxford Centre for Evidence‐based Medicine and quality was assessed using the Newcastle‐Ottawa Scale criteria.Results and ConclusionsThe literature search resulted in the identification of 1991 articles. A total of 181 full articles were screened, and 66 articles were included in this analysis. Several studies reported that recurrent/metastatic HPV‐positive HNSCC had higher rates of TP53 mutation and were genomically similar to HPV‐negative HNSCC. The detection of circulating tumour tissue‐modified HPV DNA (ctHPVDNA) as a specific biomarker has shown promising results for monitoring treatment response and recurrence in the subset of HPV‐positive HNSCC. In addition, evidence for targeted therapy in recurrent/metastatic HPV‐positive HNSCC has emerged, including agents that inhibit overexpressed EGFR. Studies of combination immunotherapy are also underway.Our review outlines the latest evidence on the distinct molecular profiles of recurrent/metastatic HPV‐positive HNSCC as well as the clinical potential of ctHPVDNA testing in routine practice. More controlled and longitudinal studies are needed to identify additional molecular targets and to assess the performance and benefits of novel molecular biomarkers in clinical practice.
Exploring local perceptions and drivers of engagement in biodiversity monitoring among participants in payments for ecosystem services schemes in southeastern Mexico
Authors: Izquierdo‐Tort Santiago , Alatorre Andrea , Arroyo‐Gerala Paulina , Shapiro‐Garza Elizabeth , Naime Julia , Dupras Jérôme 
Published: April 2024

AbstractPayments for ecosystem services (PES) are widely applied incentive‐based instruments with diverse objectives that increasingly include biodiversity conservation. Yet, there is a gap in understanding of how to best assess and monitor programs’ biodiversity outcomes. We examined perceptions and drivers of engagement related to biodiversity monitoring through surveys among current PES participants in 7 communities in Mexico's Selva Lacandona. We conducted workshops among survey participants that included training and field deployment of tools used to monitor biodiversity and land cover, including visual transects, camera traps, acoustic recorders, and forest cover satellite images. We conducted pre‐ and postworkshop surveys in each community to evaluate changes in respondents’ perceptions following exposure to biodiversity monitoring training and related field activities. We also reviewed existing research on participatory environmental management and monitoring approaches. One quarter of current PES participants in the study area participated in our surveys and workshops. The majority stated interest in engaging in diverse activities related to the procedural aspects of biodiversity monitoring (e.g., planning, field data collection, results dissemination) and acknowledged multiple benefits of introducing biodiversity monitoring into PES (e.g., knowledge and capacity building, improved natural resource management, and greater support for conservation). Household economic reliance on PES was positively associated with willingness to engage in monitoring. Technical expertise, time, and monetary constraints were deterrents. Respondents were most interested in monitoring mammals, birds, and plants and using visual transects, camera traps, and forest cover satellite images. Exposure to monitoring enhanced subsequent interest in monitoring by providing respondents with new insights from their communities related to deforestation and species’ abundance and diversity. Respondents identified key strengths and weaknesses of applying different monitoring tools, which suggests that deploying multiple tools simultaneously can increase local engagement and produce complementary findings and data. Overall, our findings support the relevance and usefulness of incorporating participatory biodiversity monitoring into PES.
Welche Faktoren beeinflussen die Teilnahme am gesetzlichen Hautkrebsscreenings in Deutschland?
Authors: Andrees Valerie , Wolf Sandra , Liebers Jan , Augustin Matthias , Girbig Gefion 
Published: April 2024

ZusammenfassungHintergrund und ZieleAufgrund der steigenden Hautkrebsinzidenz wurde in Deutschland im Jahr 2008 ein bundesweites gesetzliches Hautkrebsscreening (gHKS) eingeführt. Die vorliegende Studie zielt darauf ab, (1) zu analysieren, welche patientenseitigen Faktoren mit der Teilnahme am gHKS in Deutschland assoziiert sind und (2) die Gründe für die Nichtteilnahme zu untersuchen.Patienten und MethodikTeilnehmer und Nichtteilnehmer von gHKS (≥ 35 Jahre) wurden im Rahmen der Routineversorgung in neun dermatologischen Ambulanzen rekrutiert. Es wurden Gründe für die (Nicht‐)Teilnahme, Wissen über Hautkrebs sowie klinische und sozioökonomische Daten erhoben. Nach Gruppen stratifiziert, wurden deskriptive Analysen und binäre logistische Regressionsanalysen für Zusammenhänge mit der Teilnahme durchgeführt.ErgebnisseVon den 294 gHKS‐Teilnehmern und 162 Nichtteilnehmern waren 46,5% männlich mit einem Durchschnittsalter von 54,5 ± 12,7 Jahren. Insgesamt hatten 87,1% der Teilnehmer in ihrer Kindheit einen Sonnenbrand und 47,1% hatten bereits Sonnenbanken benutzt. Höheres Alter, weibliches Geschlecht, frühere Nutzung von Sonnenbanken sowie die Sorge um und das Wissen über Hautkrebs standen in signifikantem Zusammenhang mit einer bisherigen Teilnahme an gHKS. Von den Nichtteilnehmern wussten 46% nichts von der Möglichkeit eines kostenlosen gHKS, und 40% begründeten ihre Nichtteilnahme mit dem Gefühl gesund zu sein.SchlussfolgerungenDie Gründe für die Nichtteilnahme an gHKS wie soziodemografische Merkmale und Risikoverhalten sollten bekannt sein, damit gHKS‐Programme optimiert werden können.
Managing hypertriglyceridemia for cardiovascular disease prevention: Lessons from the PROMINENT trial
Authors: Yamashita Shizuya , Hirano Tsutomu , Shimano Hitoshi , Tsukamoto Kazuhisa , Yoshida Masayuki , Yoshida Hiroshi 
Published: April 2024

AbstractBackgroundNumerous epidemiological studies have shown that hypertriglyceridemia is a significant risk factor for cardiovascular diseases (CVD). However, large clinical studies on triglyceride‐lowering therapy have yielded inconsistent results. In the current review, we reassess the importance of triglyceride‐lowering therapy in preventing CVD based on previous literature and the recently published findings of the PROMINENT trial.MethodsThis narrative review is based on literature and public documents published up to November 2023.ResultsMeta‐analyses of trials on peroxisome proliferator‐activated receptor α agonists and triglyceride‐lowering therapy, including the PROMINENT trial, have indicated that triglyceride‐lowering therapy can reduce CVD events. Mendelian randomization studies have also indicated that triglyceride is indeed a true risk factor for coronary artery disease, leaving no doubt about its relationship to CVD. Meanwhile, the negative results from the PROMINENT trial were likely due to the insufficient triglyceride‐lowering effect, slight increases in low‐density lipoprotein cholesterol and apolipoprotein B, and the inclusion of mostly high‐intensity statin users as target patients. It is unlikely that adverse events counteracted the effectiveness of pemafibrate on outcomes. Additionally, pemafibrate has shown positive effects on non‐alcoholic fatty liver disease and peripheral artery disease.ConclusionAlthough the PROMINENT trial did not demonstrate the significance of pemafibrate as a triglyceride‐lowering therapy in a specific population, it does not necessarily negate the potential benefits of treating hypertriglyceridemia in reducing CVD events. It is necessary to explore appropriate populations that could benefit from this therapy, utilize data from the PROMINENT trial and other databases, and validate findings in real‐world settings.
Front‐line and second‐line treatment for mantle cell lymphoma in clinical practice: A multicenter retrospective analysis
Authors: Harmanen Minna , Sorigue Marc , Khan Madiha , Prusila Roosa , Klaavuniemi Tuula , Kari Esa , Jantunen Esa , Sunela Kaisa , Rajamäki Aino , Alanne Erika , Kuitunen Hanne , Jukkola Arja , Sancho Juan‐Manuel , Kuittinen Outi , Rönkä Aino 
Published: April 2024

AbstractBackgroundThere are few reports of clinical practice treatment patterns and efficacy in mantle cell lymphoma (MCL).Materials and MethodsWe retrospectively studied a large, multicenter, cohort of patients with MCL diagnosed between 2000 and 2020 in eight institutions.Results536 patients were registered (73% male, median of 70 years). Front‐line treatment was based on high‐dose cytarabine, bendamustine, and anthracyclines in 42%, 12%, and 15%, respectively. The median PFS for all patients was 45 months; 68, 34, and 30 months for those who received high‐dose cytarabine‐based, bendamustine‐based and anthracycline‐based therapy. 204 patients received second‐line. Bendamustine‐based treatment was the most common second‐line regimen (36% of patients). The median second‐line PFS (sPFS) for the entire cohort was 14 months; 19, 24, and 31 for bendamustine‐, platinum‐, and high‐dose cytarabine‐based regimens, with broad confidence intervals for these latter estimates. Patients treated with cytarabine‐based therapies in the front‐line and those with front‐line PFS longer than 24 months had a substantially superior sPFS.ConclusionFront‐line treatment in this cohort of MCL was as expected and with a median PFS of over 3.5 years. Second‐line treatment strategies were heterogeneous and the median second‐line PFS was little over 1 year.
Effects of flooding and warming on soil nitrogen fraction transformation under low‐molecular‐weight organic acid inputs
Authors: He Liping , Zhao Yashuai , Lan Bo , Tian Tao , Wen Ming , Tong Bo , Gu Yuhan , Su Dingxin , Yan Wenlian , Wang Longqing 
Published: April 2024

AbstractFlooding and climate warming lead to the increase of low‐molecular‐weight organic acid (LMWOA) inputs to soil. However, it is unclear what the effects of flooding and climate warming on soil nitrogen fraction transformation under LMWOA input are. Fluvisol was collected in the riparian zone of the Three Gorges Reservoir to conduct an incubation experiment with the treatments of three LMWOAs at five contents, two hydrological environments and two temperatures. Compared with LMWOA input of 0 mg kg−1, the soil nitrogen in ion exchangeable fraction (IEF‐N), strong oxidant extractable fraction (SOEF‐N) and non‐transformable nitrogen (NTF‐N) were increased by 35.77, 54.71 and 25.49 mg kg−1, respectively, under LMWOA input of 40 mmol kg−1. Soil nitrogen in the weak acid extractable fraction (WAEF‐N) was decreased by 117.41 mg kg−1. Microbial biomass nitrogen (MBN) was increased by 25.29 mg kg−1, and calcium carbonate (CaCO3) was decreased by 8.03 g kg−1. The contents of IEF‐N, NTF‐N and amorphous iron oxides were higher under the flooding environment than under the drying environment. In contrast, opposite results were observed for soil nitrogen in the strong alkali extractable fraction (SAEF‐N), SOEF‐N and MBN. IEF‐N and NTF‐N contents were higher at 20°C than at 30°C, and the contents of SOEF‐N and MBN were higher at 30°C than at 20°C. WAEF‐N was dissolved by LMWOA through CaCO3 dissolution. The dissolved WAEF‐N was partly transformed into SOEF‐N and NTF‐N by microbial assimilation and humification. Flooding desorbed SAEF‐N through the crystalline transformation of iron oxides. Flooding inhibited the transformation of IEF‐N to SOEF‐N and promoted the formation of NTF‐N, while warming did the opposite. The results provide a perspective of the bound state between soil and nitrogen for understanding the soil nitrogen cycling and help to assess the impacts of climate warming and flooding on soil nitrogen loss from soil to the surrounding water.
Extended ozone depletion and reduced snow and ice cover—Consequences for Antarctic biota
Authors: Robinson Sharon A. , Revell Laura E. , Mackenzie Roy , Ossola Rachele 
Published: April 2024

AbstractStratospheric ozone, which has been depleted in recent decades by the release of anthropogenic gases, is critical for shielding the biosphere against ultraviolet‐B (UV‐B) radiation. Although the ozone layer is expected to recover before the end of the 21st century, a hole over Antarctica continues to appear each year. Ozone depletion usually peaks between September and October, when fortunately, most Antarctic terrestrial vegetation and soil biota is frozen, dormant and protected under snow cover. Similarly, much marine life is protected by sea ice cover. The ozone hole used to close before the onset of Antarctic summer, meaning that most biota were not exposed to severe springtime UV‐B fluxes. However, in recent years, ozone depletion has persisted into December, which marks the beginning of austral summer. Early summertime ozone depletion is concerning: high incident UV‐B radiation coincident with snowmelt and emergence of vegetation will mean biota is more exposed. The start of summer is also peak breeding season for many animals, thus extreme UV‐B exposure (UV index up to 14) may come at a vulnerable time in their life cycle. Climate change, including changing wind patterns and strength, and particularly declining sea ice, are likely to compound UV‐B exposure of Antarctic organisms, through earlier ice and snowmelt, heatwaves and droughts. Antarctic field research conducted decades ago tended to study UV impacts in isolation and more research that considers multiple climate impacts, and the true magnitude and timing of current UV increases is needed.
Local reflects global: Life stage‐dependent changes in the phenology of coastal habitat use by North Sea herring
Authors: Rademaker Mark , Peck Myron A. , van Leeuwen Anieke 
Published: April 2024

AbstractClimate warming is affecting the suitability and utilization of coastal habitats by marine fishes around the world. Phenological changes are an important indicator of population responses to climate‐induced changes but remain difficult to detect in marine fish populations. The design of large‐scale monitoring surveys does not allow fine‐grained temporal inference of population responses, while the responses of ecologically and economically important species groups such as small pelagic fish are particularly sensitive to temporal resolution. Here, we use the longest, highest resolution time series of species composition and abundance of marine fishes in northern Europe to detect possible phenological shifts in the small pelagic North Sea herring. We detect a clear forward temporal shift in the phenology of nearshore habitat use by small juvenile North Sea herring. This forward shift might be linked to changes in water temperatures in the North Sea. We next assessed the robustness of the effects we found with respect to monitoring design. We find that reducing the temporal resolution of our data to reflect the resolution typical of larger surveys makes it difficult to detect phenological shifts and drastically reduces the effect sizes of environmental covariates such as seawater temperature. Our study therefore shows how local, long‐term, high‐resolution time series of fish catches are essential to understand the general phenological responses of marine fishes to climate warming and to define ecological indicators of system‐level changes.