bluuebunny/crossref_metadata_2025_split huggingface dataset:
Decentralized Pub/Sub Architecture for Real-Time Remote Patient Monitoring: A Feasibility Study
Authors: Haque Kazi Nymul , Islam Johirul , Ahmad Ijaz , Harjula Erkki 
Published: May 2024

AbstractThe confluence of the Internet of Things (IoT) within the healthcare sector, called Internet of Medical Things (IoMT), has ushered in a transformative approach to real-time patient monitoring. Traditional methods that typically involve the direct transmission of medical sensor data to the cloud, falter under the constraints of medical IoT devices. In response, Multi-access Edge Computing (MEC), as defined by the European Telecommunications Standards Institute (ETSI), brings forth an innovative solution by relocating computing resources closer to the origin of data. However, MEC alone does not fully address the exigencies of constrained medical IoTs in the realm of real-time monitoring. Our architecture advances the computing continuum by seamlessly integrating local edge computing for direct data capture, MEC for nuanced data processing, and cloud computing for the comprehensive synthesis and presentation of data. This synergy is further enhanced by the introduction of a robust message queue mechanism, assuring data resilience and uninterrupted data streaming during network disruptions. With a steadfast commitment to security, our system employs stringent measures to ensure the integrity and confidentiality of sensitive patient data during transmission. This architecture represents a significant leap in healthcare technology, emphasizing the criticality of patient safety, data security, and meticulous data management. The implications of this study are profound, indicating a trajectory for future exploration into the integration of sophisticated data types and AI-driven models to further refine patient monitoring and healthcare outcomes.
A Skewness-Based Harmonic Filter for Harmonic Attenuation of Wearable Functional Near-Infrared Spectroscopy Signals
Authors: Ferdinando Hany , Ilvesmäki Martti , Kananen Janne , Moradi Sadegh , Myllylä Teemu 
Published: May 2024

AbstractHarmonics is an unavoidable phenomenon, even before we knew about digital circuits. In our sleep study, we found harmonic artefacts (HA) in our functional near-infrared spectroscopy (fNIRS) signal. Interestingly, it was neither device- nor subject-dependent. The fundamental frequency was around either 0.5 Hz or 1 Hz. It appeared to be very sharp peaks and they were within the band of interest, i.e., respiratory (0.1–0.6 Hz) and cardiac (0.6–5 Hz) bands. Since the exact location might change, we proposed a skewness-based harmonic filter (sbHF) to identify the fundamental frequency and attenuate HA. Since suppressing certain frequencies may change signal characteristic, spectral entropy was used to evaluate it based on Wilcoxon-test at a 0.05 significant level. 25 controls (6 females, age: 39.0 ± 8.5 years, height: 175.6 ± 8.0 cm, weight: 80.3 ± 10.8 kg) and 16 sleep apnea patients (1 female, age: 48.3 ± 12.4 years, height: 177.3 ± 6.0 cm, weight: 93.6 ± 17.1 kg) were recruited for our sleep study. sbHF showed good performance to identify fundamental frequency and attenuate HA from our raw fNIRS signals and 5% of the signal experienced changes in signal characteristics based on the spectral entropy analysis. Combining sbHF with a certain motion artefact reduction, we found that specific order of operation to get appropriate chromophore concentration was needed. This method is not only for problems in wearable fNIRS, but also can be modified for other problems by adjusting the suspected area or sweeping the frequency range to identify a fundamental frequency.
Drug Recommendation System for Healthcare Professionals’ Decision-Making Using Opinion Mining and Machine Learning
Authors: Keikhosrokiani Pantea , Balasubramaniam Katheeravan , Isomursu Minna 
Published: May 2024

AbstractThe concern has been raised regarding errors in drugs prescription and medical diagnostics that need to be carefully thought through. Both patient diagnosis and medication prescription are the responsibilities of healthcare providers. As the number of people with health issues rises, the healthcare professionals’ burden is increased. Medical errors may occur in the healthcare sector as a result of healthcare professionals prescribing drugs medicines based on inadequate information related to patient history and drug side effects. Therefore, this study aims to propose a drug recommender system to assist healthcare providers in decision making when prescribing drugs for patients depending on their diagnoses. Drug reviews sentiments are analyzed to find the drug effectiveness among the users. Furthermore, the most suitable recommender algorithm for recommending drugs based on the data from healthcare professionals are selected for this study. Opinion mining is applied on drug reviews, and a hybrid method is implemented to overcome the limitations of content-based and collaborative filtering methods, such as the cold start problem and increasing client preference. The system is developed and tested successfully. The proposed system can assist healthcare professionals in drug decision making and sustain the whole digital care pathway for various diseases.
Experimental Study of In-Body Devices Misalignment Impact on Light-Based In-Body Communications
Authors: Fuada Syifaul , Särestöniemi Mariella , Katz Marcos , Soderi Simone , Hämäläinen Matti 
Published: May 2024

AbstractOptical wireless communication (OWC) has emerged as a promising technology for implantable medical devices because it provides private and secure wireless links for patients, low-power consumption, and high-speed data transmission. The OWC system’s receiving end typically relies on a photodetector with a limited field-of-view, necessitating direct line-of-sight connections for effective transmission. The directional nature of light-tissue interaction on the in-body communication can be problematic as the quality of the optical signal is rapidly deteriorated due to the properties of biological tissues, including scattering, absorption, and reflection, leading to a substantial loss of optical beam power reaching the photodetector’s sensitive area. In this sense, any misalignment that occurs in the in-body device can directly impact the power level and further degrade the received signal quality. Numerous studies have been conducted on this topic in free-space environments; nevertheless, only a few results have been found for in-body cases. In this work, we experimentally demonstrate the impact of the in-body device misalignment on the OWC-based in-body communication system. Three cases were investigated: aligned systems, as well as lateral and angular misalignments. We considered an 810 nm Near-infrared (NIR) LED as a transmitter because the optical signal of the mentioned wavelength propagates better than other wavelengths through biological tissues. For the experiments, we used pure muscle and fat tissues with 15 mm thickness at different temperatures (23 ℃ and 37 ℃). We also tested with thicker meat samples (30 mm, 38 mm, and 40 mm, consisting of muscle + fat layers) at 37 ℃. This study adhered to ANSI.Z136.1–2007 safety standards. First, the results reveal that optical power still reaches the receiver in an aligned reference case at a meat thickness of 40 mm. Second, the in-body device misalignment significantly degrades the optical power density received, which is more pronounced under lateral than angular conditions. These misalignment effects must be carefully considered for further system enhancement when using OWC for the in-body communication system.
A Persuasive mHealth Application for Postoperative Cardiac Procedures: Prototype Design and Usability Study
Authors: de Oliveira Renata Savian Colvero , Dal Sasso Grace T Marcon , Iyengar Sriram , Oinas-Kukkonen Harri 
Published: May 2024

AbstractThe global burden of cardiovascular diseases (CVD) is a worldwide public health problem. In 2019, 18.6 million people died from CVD, representing a 17.1% increase compared to 2010. Also, some individuals who experience a cardiovascular event will require some form of cardiovascular procedure, such as a pacemaker or implantable cardioverter-defibrillator insertion, aneurysm repair, or heart valve replacement. Mobile health (mHealth) is a valuable tool for supporting individuals with CVD in self-management, providing medical recommendations, virtual consultations, reminders, and disease monitoring notifications. The main objective of this research was to enhance postoperative care for cardiac procedures. To achieve this, the research involved the development of a new mHealth application and the subsequent evaluation of its usability. The study constituted technological and usability research by using Design Science Research Methodology (DSRM). The design of the mobile application followed the principles of Persuasive Systems Design (PSD) model, which encompass a clear definition of the main task, user interaction through dialogue, system credibility, and social support, aiming to help change user behavior. The sample was non-probabilistic for convenience, and System Usability Scale (SUS) was applied to physicians and nurses as well as individuals in the information technology field. The sample comprised 18 participants, of whom 55.6% were female. The participants rated the application positively, with a median final SUS score of 95 (IQR 90–97.5). Finally, the mobile application presented high usability and user acceptance.
Urinary Incontinence in Active Female Young Adults: Healthcare Preferences, Priorities and Experiences
Authors: Newark Rebecca L. , Thompson Rachel 
Published: May 2024

Abstract
Introduction and Hypothesis
There is a paucity of evidence on the healthcare preferences of active female young adults with urinary incontinence (UI). This research is aimed at examining the population’s healthcare preferences and priorities and their characteristics and experiences to improve access to and use of services.

Methods
This cross-sectional online survey study used a convenience community sample. Participants resided in Australia, were 18–30 years old, had self-reported engagement in physical activity of any frequency and self-reported urine leakage in the previous 4 weeks and met other eligibility criteria. Data were analysed using descriptive analyses.

Results
Thirty-nine participants took part in the study. The majority engaged in recreational exercise (74.2%) and experienced UI of slight to moderate severity (82.9%). Participants preferred to access information and support anonymously online (71.4%) from general practitioners (58.8%), medical specialists (50.0%) or physiotherapists (44.1%). All participants wanted to be involved in the UI management decision-making process. Participants prioritised knowing information over cost (38.2%), changes to daily habits (35.3%) and potential risks or side effects (23.5%) when making decisions about management of UI.

Conclusion
The results highlight the diversity among active female young adults with UI. They emphasise the need for shared decision making and highlight key information needs, providing the basis for the development of decision-making tools and protocols specific to this population. They demonstrate the need for anonymous online information and support, and draw attention to the presence of UI among young recreational exercisers, highlighting the importance of ensuring that information and support is available within this demographic.
Dopamine, activation of ingestion and evaluation of response efficacy: a focus on the within-session time-course of licking burst number
Authors: D’Aquila Paolo S. 
Published: May 2024

AbstractRationaleEvidence on the effect of dopamine D1-like and D2-like receptor antagonists on licking microstructure and the forced swimming response led us to suggest that (i) dopamine on D1-like receptors plays a role in activating reward-directed responses and (ii) the level of response activation is reboosted based on a process of evaluation of response efficacy requiring dopamine on D2-like receptors. A main piece of evidence in support of this hypothesis is the observation that the dopamine D2-like receptor antagonist raclopride induces a within-session decrement of burst number occurring after the contact with the reward. The few published studies with a detailed analysis of the time-course of this measure were conducted in our laboratory.ObjectivesThe aim of this review is to recapitulate and discuss the evidence in support of the analysis of the within-session burst number as a behavioural substrate for the study of the mechanisms governing ingestion, behavioural activation and the related evaluation processes, and its relevance in the analysis of drug effects on ingestion.ConclusionsThe evidence gathered so far suggests that the analysis of the within-session time-course of burst number provides an important behavioural substrate for the study of the mechanisms governing ingestion, behavioural activation and the related evaluation processes, and might provide decisive evidence in the analysis of the effects of drugs on ingestion. However, further evidence from independent sources is necessary to validate the use and the proposed interpretation of this measure.
Prediction of Subsequent Vertebral Fracture After Acute Osteoporotic Fractures from Clinical and Paraspinal Muscle Features
Authors: Xiong Yuchao , Zhang Cici , Chen Xiaopei , Wu Li , Liang Shaohua , Zhang Ye , Huang Junbing , Guo Wei , Zeng Xuwen , Xu Fan 
Published: May 2024

AbstractTo construct a nomogram based on clinical factors and paraspinal muscle features to predict vertebral fractures occurring after acute osteoporotic vertebral compression fracture (OVCF). We retrospectively enrolled 307 patients with acute OVCF between January 2013 and August 2022, and performed magnetic resonance imaging of the L3/4 and L4/5 intervertebral discs (IVDs) to estimate the cross-sectional area (CSA) and degree of fatty infiltration (FI) of the paraspinal muscles. We also collected clinical and radiographic data. We used univariable and multivariable Cox proportional hazards models to identify factors that should be included in the predictive nomogram. Post-OVCF vertebral fracture occurred within 3, 12, and 24 months in 33, 69, and 98 out of the 307 patients (10.8%, 22.5%, and 31.9%, respectively). Multivariate analysis revealed that this event was associated with percutaneous vertebroplasty treatment, higher FI at the L3/4 IVD levels of the psoas muscle, and lower relative CSA of functional muscle at the L4/5 IVD levels of the multifidus muscle. Area under the curve values for subsequent vertebral fracture at 3, 12, and 24 months were 0.711, 0.724, and 0.737, respectively, indicating remarkable accuracy of the nomogram. We developed a model for predicting post-OVCF vertebral fracture from diagnostic information about prescribed treatment, FI at the L3/4 IVD levels of the psoas muscle, and relative CSA of functional muscle at the L4/5 IVD levels of the multifidus muscle. This model could facilitate personalized predictions and preventive strategies.
Phenolic compound profiling and antioxidant potential of different types of Schisandra henryi in vitro cultures
Authors: Jafernik Karolina , Kubica Paweł , Sharafan Marta , Kruk Aleksandra , Malinowska Magdalena Anna , Granica Sebastian , Szopa Agnieszka 
Published: May 2024

Abstract
Schisandra henryi is an endemic species of medicinal potential known from traditional Chinese medicine. As part of this study, a complex biotechnological and phytochemical assessment was conducted on S. henryi with a focus on phenolic compounds and antioxidant profiling. The following in vitro cultures were tested: microshoot agar and callus, microshoot agitated, and suspension, along with the microshoot culture in PlantForm bioreactors. Qualitative profiling was performed by ultra-high-performance liquid chromatography with a photodiode array detector coupled with ion-trap mass spectrophotometry with electrospray ionization and then quantitative analysis by high-performance liquid chromatography with a diode array detector using standards. In the extracts, mainly the compounds from procyanidins were identified as well as phenolic acids (neochlorogenic acid, caffeic acid, protocatechuic acid) and catechin. The highest content of phenolic compounds was found for in vitro agar microshoot culture (max. total content 229.87 mg/100 g DW) and agitated culture (max. total content 22.82 mg/100 g DW). The max. TPC measured using the Folin-Ciocalteu assay was equal to 1240.51 mg GAE/100 g DW (agar microshoot culture). The extracts were evaluated for their antioxidant potential by the DPPH, FRAP, and chelate iron ion assays. The highest potential was indicated for agar microshoot culture (90% of inhibition and 59.31 nM/L TEAC, respectively). The research conducted on the polyphenol profiling and antioxidant potential of S. henryi in vitro culture extracts indicates the high therapeutic potential of this species.

Key points
• Different types of S. henryi in vitro cultures were compared for the first time.
• The S. henryi in vitro culture strong antioxidant potential was determined for the first time.
• The polyphenol profiling of different types of S. henryi in vitro cultures was shown.
An Innovative Treatment Using Calcium Hydroxyapatite for Non-Surgical Facial Rejuvenation: The Vectorial-Lift Technique
Authors: Amaral Virginia Marcia , Ramos Helena Hotz Arroyo , Cavallieri Fernanda Aquino , Muniz Mariana , Muzy Guilherme , de Almeida Ada Trindade 
Published: May 2024

Abstract
Background
The facial aging process entails alterations in the volume, shape, and texture of all skin layers over time. Calcium hydroxyapatite (CaHA) is a well-established safe skin filler with unique properties to resolve some skin alterations by stimulating neocollagenesis. The vectoral-lift (V-lift) technique targets the global repositioning of facial structures by addressing distinct anatomical injection planes. It includes deep facial augmentation with Radiesse PlusTM to retain ligament restructuring and superficial subcutaneous enhancement with diluted Radiesse DuoTM. Herein, we present cases that illustrate the use of this approach.

Methods
This pilot study enrolled 36 participants (33 women and three men; ages 37–68 years) in a Brazilian clinical setting, and all patients underwent a single treatment. Photographs were taken at rest, in frontal and oblique views, before injection, and 90 days after treatment.

Results
Treatment resulted in elevation of the upper and middle face, notable improvements in the infraorbital hollow, and adjustment of the mean facial volume.

Conclusions
The V-lift technique is a three-dimensional pan-facial treatment that relies on ligament support and face vectoring to obtain a lifting effect and facial contour restoration. It encompasses deep facial augmentation involving the use of Radiesse PlusTM for restructuring and retaining ligaments and Radiesse DuoTM for superficial subcutaneous enhancement. This approach targets a global repositioning of the facial structures by addressing distinct anatomical injection planes. It achieves a repositioning of the overall facial anatomy without requiring a substantial volumetric expansion.

Level of Evidence IV
This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266.
Aberrant ecotropic viral integration site-1 (EVI-1) and myocyte enhancer factor 2 C gene (MEF2C) in adult acute myeloid leukemia are associated with adverse t (9:22) & 11q23 rearrangements
Authors: Menshawy Nadia El , El-Ghonemy Mohamed S. , Ebrahim Mohamed A. , Fahmi Maryan Waheeb , Saif Maha , Denewer May , El-Ashwah Shaimaa 
Published: May 2024

AbstractAcute myeloid leukemia (AML) shows multiple chromosomal translocations & point mutations which can be used to refine risk-adapted therapy in AML patients. Ecotropic viral integration site-1 (EVI-1) & myocyte enhancer factor 2 C gene (MEF2C) are key regulatory transcription factors in hematopoiesis and leukemogenesis & both drive immune escape.This prospective study involved 80 adult de novo AML patients recruited from Oncology Center, Mansoura University, between March 2019 and July 2021. The MEF2C and EVI1 expression were measured using a Taqman probe-based qPCR assay.The results revealed that EVI1 and MEF2C expression were significantly elevated in AML patients as compared to control subjects (p = 0.001. 0.007 respectively). Aberrant expressions of EVI1 and MEF2C showed a significant negative correlation with hemoglobin levels (p = 0.034, 0.025 respectively), & bone marrow blasts (p = 0.007, 0.002 respectively). 11q23 translocation was significantly associated with EVI1 and MEF2C (p = 0.004 and 0.02 respectively). Also, t (9;22) was significantly associated with EVI1 and MEF2C (p = 0.01 and 0.03 respectively), higher expression of EVI1 and MEF2C were significantly associated with inferior outcome after induction therapy (p = 0.001 and 0.018 respectively) and shorter overall survival (p = 0.001, 0.014 respectively).In conclusion, EVI1 & MEF2C were significantly expressed in AML cases. EVI1 & MEF2C overexpression were significantly associated with 11q23 rearrangements and t (9;22) and were indicators for poor outcome in adult AML patients; These results could be a step towards personalized therapy in those patients.
Accumulation of Hydrogen Peroxide in Flag Leaves Induces Effective Regeneration of Triticale During Rehydration After Water Stress
Authors: Ostrowska Agnieszka , Hura Katarzyna , Hura Tomasz 
Published: May 2024

AbstractA key element in the effective recovery of plants after drought is slowing down of their senescence accelerated during the drought. Therefore, in this paper the relationships between hydrogen peroxide content and effective recovery during rehydration after water stress were analyzed. The study focused on two DH lines of winter triticale with different regeneration potential, as shown by different numbers of lateral stems with ears, grown during rehydration after water stress. During rehydration, the GZDH27 line grows two to three lateral stems with ears, whereas the GZDH88 line grows a single lateral stem with ear. The two DH lines of winter triticale showed comparable responses to the drought stress but their responses to rehydration after the drought stress were clearly different. Results revealed, that the increased accumulation of hydrogen peroxide, which was induced during the drought, can be maintained during rehydration, thus stimulating plant senescence. In the line GZDH88, rehydration did not slow down drought-induced senescence. This was manifested by higher levels of hydrogen peroxide, accompanied by lower levels of chlorophyll in the flag leaves of GZDH88 plants, as the result of which only one lateral stem was formed during rehydration. However, development of one lateral stems during rehydration in the GZDH88 line allowed for smaller yield loss than in the GZDH77 line, that developed of three lateral stems during rehydration. The efficient production of carbohydrates and their effective allocation into the ears of the lateral stems required considerable energy expenditure in the GZDH27 line. Our results indicate that growing three lateral stems with ears during rehydration does not guarantee limitation of grain yield loss. However, to reach the final conclusion, it is important to evaluate a greater number of triticale genotypes under drought stress and rehydration during various stages of a plants development.