bluuebunny/crossref_metadata_2025_split huggingface dataset:
Synthesis, in vitro activity, and molecular docking of caffeic acid and resveratrol derivatives against Alzheimer's disease-related enzymes
Authors: Martinez Alberto 
Published: June 2024

Abstract

Alzheimer’s disease (AD) is the most common form of dementia affecting about 40 million people around the world. The number of people living with this ailment is expected to triple in the next 50 years due to the aging population and the lack of any effective treatment. In this work we have synthesized a group of three hybrid caffeic acid and a resveratrol derivatives (1-4), and we have tested their ability to inhibit in vitro the enzymatic activity of beta-site amyloid precursor protein cleaving protein enzyme 1 (BACE 1) and acetylcholinesterase (AChE). The inhibitory activity was compared to that of parent compounds caffeic acid and resveratrol, as well as related chlorogenic acid. Clinically tested LY2811376 and tacrine were used as positive controls. All three caffeic acid derivatives displayed better inhibitory activity than parent caffeic acid and chlorogenic acid. In particular, the in vitro IC50 for compound 4 against BACE 1 fell in the nanomolar range (69 ± 5 nM), comparable or better than LY2811376 (173 ± 8 nM), a BACE 1 inhibitor that reached Phase I clinical trials against AD. On the other hand, compound 3 showed a remarkable AChE inhibitory potency in the low micromolar range (1.93 ± 0.16 μM). Molecular docking was performed to gain valuable insights into the interactions between compounds 1-4 and the active sites of both BACE 1 and AChE. Calculated binding affinities generally correlated well with experimental in vitro inhibition. Experimental and molecular docking results validated the proposed drug design, since the most active compounds 3 and 4 established interactions with relevant amino acid residues of the BACE 1 and AChE active sites through the different pharmacophore features of the hybrid structures. Overall, the results presented in this work could potentially have important implications in the rational design of compounds with potential anti-AD properties.
Optimization of Classifiers Performance for Node Embedding on Graph Based Data
Authors: Yadav Neha , Gopinathan Dhanalekshmi 
Published: June 2024

Abstract

The Publications regarding the research of embedding the large-scale information that helps in getting networks utilizing neighborhood-aware node representations and low-dimensional communities cover a wide area of research. In graph mining applications, these classification models, and embedding performed better than the conventional approaches. When using different conventional machine learning and data analysis approaches, the display of graphs and their relationship is highly useful in describing features present. Many different embedding approaches are used in machine learning, and a literature review was conducted to determine the best techniques for comparison. This study examines the accuracy scores of different classifiers using the approach on a single dataset. The dataset which is used in this study is CORA, and it is used to import it. After the network has been formed using the dataset, the nodes are embedded since the result of this node embedding will be used as a training set. The machine learns through training of model, for which the Node2vex method is applied in this work. The classifiers are used to train the model. Gradient Boosting, Logistic Regression, Random Forest, K-Neighbors, Decision Tree, Gaussian, and SVC are the classifiers utilized to solve this model's classification problem. To assess performance, the model makes use of two classifiers: Gradient Boosting, Logistic Regression, Random Forest, K-Neighbors, Decision Tree, Gaussian, and SVC. Through experimentation, the accuracy score is used to compare the classifier’s levels of efficiency. From the study, it was clearly observed that for the dataset, it was only the Support Vector Classifier that performed best in the testing and training of dataset for getting desired result. This was achieved by achieving an accuracy of 0.7706 and an MCC score of 0.7200. The optimum classifier for model training tasks and node classification can be chosen with the aid of this paper.
1mΨ influences the performance of various positive-stranded RNA virus-based replicons
Authors: Miyazato Paola , Noguchi Takafumi , Ogawa Fumiyo , Sugimoto Takeshi , Fauzyah Yuzy , Sasaki Ryo , Ebina Hirotaka 
Published: June 2024

Abstract

Self-amplifying RNAs (saRNAs) are versatile vaccine platforms that take advantage of a viral RNA-dependent RNA polymerase (RdRp) to amplify the mRNA of an antigen of interest encoded within the backbone of the viral genome once inside the target cell. In recent years, more saRNA vaccines have been clinically tested with the hope of reducing the vaccination dose compared to the conventional mRNA approach. The use of N1-methyl-pseudouridine (1mY), which enhances RNA stability and reduces the innate immune response triggered by RNAs, is among the improvements included in the current mRNA vaccines. In the present study, we evaluated the effects of this modified nucleoside on various saRNA platforms based on different viruses. The results showed that different stages of the replication process were affected depending on the backbone virus. For TNCL, an insect virus of the Alphanodavirus genus, replication was impaired by poor recognition of viral RNA by RdRp. In contrast, the translation step was severely abrogated in coxsackievirus B3 (CVB3), a member of the Picornaviridae family. Finally, the effects of 1mΨ on Semliki forest virus (SFV), were not detrimental in in vitro studies, but no advantages were observed when immunogenicity was tested in vivo.
Telomere length in relation to fecundability and use of assisted reproductive technologies: the Norwegian Mother, Father, and Child Cohort Study
Authors: Skåra Karoline Hansen , Lee Yunsung , Jugessur Astanand , Gjessing Håkon K. , Aviv Abraham , Brumpton Ben , Naess Øyvind , Hernáez Álvaro , Hanevik Hans Ivar , Magnus Per , Magnus Maria C. 
Published: June 2024

Abstract

In women, shorter telomeres have been reported to be associated with conditions such as endometriosis and polycystic ovary syndrome, whereas other studies have reported the opposite. In men, studies mostly report associations between shorter telomeres and sperm quality. To our knowledge, no studies have thus far investigated the associations between TL and fecundability or the use of ART.
This study is based on the Norwegian Mother, Father, and Child Cohort (MoBa) Study and uses data from the Medical Birth Registry of Norway (MBRN). We included women (24,645 with genotype data and 1,054 with TL measurements) and men (18,339 with genotype data and 965 with TL measurements) participating between 1998 and 2008. We investigated the associations between leukocyte TL and fecundability, infertility, and the use of ART. We also repeated the analyses using instrumental variables for TL, including genetic risk scores for TL and genetically predicted TL.
Approximately 11% of couples had experienced infertility and 4% had used ART. TL was not associated with fecundability among women (fecundability ratio [FR], 0.98; 95% confidence interval [CI], 0.92-1.04) or men (FR, 0.99; CI, 0.93-1.06), nor with infertility among women (odds ratio [OR], 1.03; CI, 0.85-1.24) or men (OR, 1.05; CI, 0.87-1.28). We observed an increased likelihood of using ART with increasing TL among men (OR, 1.22; CI, 1.03-1.46), but not among women (OR, 1.10; CI, 0.92-1.31). No significant associations were observed using the instrumental variables.
Our results indicate that TL is a poor biomarker of fecundability, infertility and use of ART in MoBa. Additional studies are required to replicate the association observed between TL and ART in men.
The ostracod distribution in the Sea of Galilee (Levant): species distribution and post-mortem dispersal of valves and carapaces
Authors: Mischke Steffen , Braun Paul , Ito Emi , Almogi-Labin Ahuva 
Published: June 2024

Abstract

The Sea of Galilee is the one and only large freshwater or slightly oligohaline natural lake in the Levant, and it therefore represents an important aquatic habitat in the region that also provides invaluable ecosystem services for the local communities. To improve our knowledge of the lake’s ecosystem and the use of disarticulated ostracod valves and preserved carapaces, micro-crustacean remains commonly used in palaeolimnology and palaeoceanography, as proxies for palaeoenvironmental reconstructions, and to examine the post-mortem dispersal of ostracod remains, 68 surface-sediment samples were collected from the lake floor in 2012 and analysed for the ostracod assemblages. Both, the noded and smooth, forms of Cyprideis torosa dominate in the Sea of Galilee, with the former more abundant than the latter. Relatively abundant and found at half of the 68 sampling locations or more, are also Ilyocypris hartmanni, I. cf. nitida, Darwinula stevensoni and Neglecandona angulata. In addition, ten less abundant ostracod taxa were recorded in the lake. Of all 15 taxa recorded in our study, ten were apparently also recorded in a study of the Sea of Galilee’s ostracod fauna conducted already in the 1960s. The newly recorded five taxa are relatively rare, and they were mostly found in the region of the Jordan River delta or near the southeastern shore of the lake which were not included in the survey of the 1960s. Thus, there is no evidence for a significant change in the ostracod fauna of the lake over the last half-century. In comparison to the ostracod assemblage from a late Pleistocene archaeological excavation site at the southwestern margin of the lake, the assemblage from the recent survey is slightly less diverse, probably as a result of the long duration of ca. 5000 years integrated by the sedimentary section of the archaeological site and also due to nearby freshwater inflows from which valves and carapaces were probably washed to the site’s location. Our study also shows that ostracod valves and carapaces are typically relatively abundant in most of the surface-sediment samples collected from locations at 18 m or shallower. In contrast, very few valves and carapaces were recorded at depths greater than 18 m, which is a zone affected by seasonal anoxia in the Sea of Galilee. These few ostracod remains were apparently transported by currents and waves to the central, deeper part of the lake, but their low number shows that such post-mortem dispersal of ostracod remains is insignificant in the deeper part of the lake. Thus, our study provides support for palaeoenvironmental and palaeoclimate reconstructions based on ostracod records from single sediment cores obtained from depths unaffected by post-mortem transport and seasonal or permanent anoxia.
CCR5 Decorated Rilpivirine Lipid Nanoparticles Build Myeloid Drug Depots Which Sustains Antiretroviral Activities
Authors: Gendelman Howard (E) , Patel Milankumar , Panja Sudipta , Zaman Lubaba A. , Yeapuri Pravin , Bhattarai Shaurav , Gorantla Santhi , chang Linda , Heredia Alonso , Walczak Piotr , Cohen Samuel , Kevadiya Bhavesh 
Published: June 2024

Abstract

Antiretroviral therapy (ART) improves the quality of life for those living with the human immunodeficiency virus type one (HIV-1). However, poor compliance reduces ART effectiveness and leads to immune compromise, viral mutations, and disease co-morbidities. A novel drug formulation is made whereby a lipid nanoparticle (LNP) carrying rilpivirine (RPV) is decorated with the C-C chemokine receptor type 5 (CCR5). This facilitates myeloid drug depot deposition. Particle delivery to viral reservoirs is tracked by positron emission tomography. The CCR5-mediated RPV LNP cell uptake and retention reduce HIV-1 replication in human monocyte-derived macrophages and infected humanized mice. Focused ultrasound allows the decorated LNP to penetrate the blood-brain barrier and reach brain myeloid cells. These findings offer a role for CCR5-targeted therapeutics in antiretroviral delivery to optimize HIV suppression.
Comparing Hospitalized Adult Patients with Chronic Anorexia Nervosa with versus without Prior Hospitalizations
Authors: Martinelli Mary K. , Schreyer Colleen , Guarda Angela S. 
Published: June 2024

Abstract

Background
Anorexia nervosa (AN) is a severe psychiatric disorder, for which recovery is often a protracted process, such that a proportion of individuals with AN experience a chronic illness course. The role of prior specialized inpatient treatment on subsequent treatment attempts for those with chronic AN remains unclear. Research examining predictors of treatment response for severe and enduring AN is urgently needed to improve outcomes.
Method
Participants (N = 135) with chronic AN (ill ≥7 years) admitted to an integrated inpatient-partial hospitalization eating disorders (ED) unit with prior ED hospitalization(s) (+ PH; n = 100) were compared to those without prior ED hospitalizations (-PH; n = 35) on admission characteristics (BMI, length of illness, outpatient ED treatment history, symptomatology (ED, anxiety and depressive), treatment motivation, history of suicide attempts or non-suicidal self-injury (NSSI)), and discharge outcomes (discharge BMI, rate of weight gain, length of stay, clinical improvement).
Results
At admission, groups were similar in age, prolonged length of illness, and BMIs. The + PH group however had lower desired weight, lower lifetime nadir BMI, lower self-efficacy for normative eating, and higher state and trait anxiety compared to the -PH group. The + PH group was also more likely to endorse history of NSSI and suicide attempt. Regarding discharge outcomes, the + PH group spent more days inpatient, but groups did not differ on rate of weight gain, likelihood of attending partial hospital, partial hospital length of stay, program discharge BMI, or likelihood of clinical improvement (p’s > .05).
Conclusions
Participants with chronic AN + PH exhibited more severe psychiatric comorbidity and lower self-efficacy for normative eating, but had similar short-term discharge outcomes to chronic AN -PH. Results suggest that targeting comorbidities may be important for patients who did not respond to prior intensive treatment. Although both groups had similar illness duration, those with chronic AN -PH may be distinct in terms of prognosis. For example, they may be able to transition to partial hospital earlier than those with chronic AN + PH. Longer-term data comparing these groups is needed to best individualize care and determine prognosis including relapse risk following intensive treatment and weight restoration.
Synthesis and properties of multi-porous multi-doped nano-Na 3 V 2 (PO 4 ) 3 @C materials from electroless nickel plating wastewater
Authors: Zeng Sisha , Xu Wen , Liu Wanmin , Tang Zexun , Xu Lv , Qin Mulan , Shen Bin , Wang Weigang 
Published: June 2024

Abstract

Electroless nickel plating technology displays exuberant vitality in the field of surface treatment, nevertheless accompanying with its spent plating solution for environmental pollution and resource waste. Therefore, it is of great significance how to realize the high efficient utilization of various waste ions in the electroless nickel plating wastewater (ENPW). Herein, after transforming nickel and sulfur elements in ENPW into nickel hydroxide and barium sulfate, the remaining elements serve as primary raw materials for the synthesis of multi-porous multi-doped nano-Na3V2(PO4)3@C materials (D-NVP). This is achieved by integrating the sol-gel method with the carbon thermal reduction method. The as-synthesized D-NVP displays a 3D porous skeleton structure, where the pores with different nano-micron sizes are interlinked by the skeletons with the thickness of 40–200 nm. The unique structure, combined with Mg-Ca-Fe doping, contributes to D-NVP’s excellent electrochemical properties, with the initial discharge capacities of 108, 107, 104.3, 101.5, 98.6 and 95.3 mAh·g− 1 at 0.2, 0.5, 1, 2, 5 and 10 C, and the capacity retention rates of 99.2% and 98.9% at 1 and 5 C after 200 cycles, respectively.
A virtual species study to establish baseline for assessing the predicted current and future distribution ranges of real species in mountainous areas
Authors: LIAO Chi-Cheng , CHEN Yi-Huey , LIN Huan-Yu 
Published: June 2024

Abstract

Simulation and model prediction of virtual species aim to establish baseline for assessing the projected contemporary and future distribution ranges of real species in mountainous areas. Fundamental niches and geographic ranges of 5 virtual species were defined in the diagram of principal components analysis based on a high-resolution climate dataset generated from meteorological data. Heterogeneity of the climate dataset had been validated to influence the relationships between species responses and suitable environments, consequently affecting the geographical distributions of virtual species. The performances of 11 algorithms were evaluated by the extracted fraction of shared presences (ESP), instead of TSS and AUC. ESP calculates the overlap between simulated suitable ranges and predicted current potential ranges of virtual species. According to ESP, ensemble modeling outperformed the 11 algorithms. A small sample size has significant effects on model performance due to the extremely low value of ESP, and the presence of only 5 sample points was evidently a limitation of model predictions. Furthermore, geographical distance among sample points provide signals of niches that will be identified through accurate predictions of ensemble modeling in our analyses. By the 2050s and 2090s, climate change may drive the range expansion of real species currently distributed in inland areas or on leeward slopes, while causing range restriction or local extinction of real species in coastal areas or on windward slopes. Our study can inform application of species distribution models to provide scientific support for conservation planning in mountainous areas and forecasts of species distributions under climate change.
Calibrating lower-middle Miocene mammal faunas and unravelling climate change during the Miocene Climate Optimum; the Bardenas Reales de Navarra record (Ebro basin, NE Iberian Peninsula)
Authors: Gorosquieta Juan Cruz Larrasoaña , Suarez-Hernando Oier , Beamud Elisabet , Garcés Miguel , Pérez-Landazábal José Ignacio , Gómez-Polo Cristina , Ruiz-Sánchez Francisco Javier , Mata Maria Pilar , Murelaga Xabier 
Published: June 2024

Abstract

The chronology of lower Miocene Iberian small mammal faunas is still poorly constrained given the scarcity of well dated sedimentary successions including small mammal fossil localities. Such scarcity has prevented also an accurate understanding of the response of European terrestrial ecosystem to global changes across the Miocene Climate Optimum (MCO), one of the best analogues of present-day global warming. Here we present an updated fossil small mammal record of the Bardenas Reales de Navarra (western Ebro basin, Spain), where an expanded lower to middle Miocene continental succession is superbly exposed. Previous and new magnetostratigraphic results from this succession have enabled us to propose, along with additional magnetostratigraphically-dated Iberian faunas, a new chronology for local zones Y to D (Mammal Neogene zones MN2 to MN5). In addition to that, the studied small mammal faunas point to a gradual increase in temperature and humidity conditions in SW Europe between 20 and 15.5 Ma, which appears to be coupled with the progressive shift towards warmer regional (Atlantic) and global conditions across the MCO, thereby pointing to gradual changes in oceanic circulation as the main driver of this period of global warmth. The evolution of sedimentary facies appears to indicate a threshold response of the Ebro basin hydrological balance to the MCO, whereas pedogenic formation of magnetic minerals seems to be linked to periods of enhanced climate variability. These results highlight the need of combining different paleoenvironmental indicators in order to obtain a reliable view of the response of continental ecosystems to global warming.
Infrared and visible video fusion method based on inter-frame feature association and PID control
Authors: Tnag Xiaolin , Wang Jun 
Published: June 2024

Abstract

The purpose of infrared and visible video fusion is to combine the complementary features of videos from different modalities. Most fusion algorithms ignore the feature associations of adjacent frames and the guidance of the source frames to the fusion process. Therefore, this paper proposes a new fusion method. First, a spatial-domain multi-attribute detail feature extraction model is proposed, which is capable of extracting the base layer, the bright detail layer and the dark detail layer of the source frames separately. Then, we propose an associated feature extraction model for adjacent frames, which improves the spatial continuity of the fused video. Furthermore, an exponential homomorphic filter is proposed, which simultaneously increases the dynamic range and contrast of the source infrared frames to obtain a general salient target extraction model. In the feature fusion stage, a weighted fusion rule based on edge intensity is used in the detail layer. Then we design the controller, transfer function and measurement function separately, so as to construct a closed-loop proportional-integral-derivative (PID) control system to fuse the base layer, which ensures that the fused video maintains more information of the source video. Experiments on public datasets demonstrate that our fusion method outperforms some state-of-the-art algorithms. Code: https://github.com/Tang2956/Infrared-and-visible-video-fusion-method-based-on-inter-frame-feature-association-and-PID-control
Development and Performance Evaluation of a Hybrid Fractional Order Proportional Integral Controller for Grid-Connected Inverters
Authors: BEDDAR ANTAR , ABADLIA ISSAM 
Published: June 2024

Abstract

This article proposes the development of a Hybrid Fractional Order Proportional Integral (HFOPI) controller for decoupled active (P) and reactive (Q) power control to improve grid-connected inverter performances. The proposed controller gains are numerically tuned using the isodamping feature, which is a frequently used frequency method. The system under study is a grid-connected inverter system that contains a DC source, a three-phase inverter connected to the grid through an L filter. The proposed controller HFOPI combines a Variable Gain PI (VGPI) controller work in alternative with a Fractional Order PI (FOPI) controller and a selection algorithm that organize the two controller’s interventions. The performance and robustness of the proposed HFOPI controller is examined and assessed under various scenarios such as suddenly step change in active and reactive power references and compared with the simple structure based on FOPI or PI controller. The simulation is carried out using MATLAB/Simulink. Moreover, the grid-connected inverter test bench is set up in the laboratory. Where, the experimental results are consistent with the simulation and prove that the proposed HFOPI controller provides an important amelioration in term of maximum first overshoot/undershoot, tracking settling time and lower injected current Total Harmonic Distortion (THD) compared to the simple structure based on the PI/FOPI controllers.