bluuebunny/crossref_metadata_2025_split huggingface dataset:
Subacute combined degeneration of the spinal cord with cerebellar lesions: A case report
Authors: Zhu Manmin , Yu Changyin , Xu Zucai , Zhang Haiqing , Huang Hao 
Published: May 2024

Rationale:
Subacute combined degeneration of the spinal cord is a degenerative disease of the central and peripheral nervous systems caused by vitamin B12 deficiency, mainly involving the spinal cord posterior, lateral, and peripheral nerves, but rarely involving the cerebellum.

Patient concerns:
A 41-year-old woman presented with a 2-year history of walking unsteadily. Her hematologic examination revealed megaloblastic anemia and vitamin B12 deficiency. Electromyography showed multiple peripheral nerve damage (sensory fibers and motor fibers were involved). Imaging examination showed long T2 signal in the cervical, thoracic and lumbar spinal cord and cerebellum. Gastroscopy revealed autoimmune gastritis.

Diagnoses:
Subacute combined degeneration of the spinal cord.

Interventions:
By supplementing with vitamin B12.

Outcomes:
The patient’s symptoms of limb weakness, diet, and consciousness were improved, and the muscle strength of both lower limbs recovered to grade IV.

Lessons:
The symptomatic people should seek medical treatment in time to avoid further deterioration of the disease. When esophagogastroduodenoscopy is performed as part of routine physical examination in asymptomatic people, it should be checked for the presence of autoimmune gastritis. Early diagnosis can prevent irreversible neuropathy.
Tislelizumab combined with GT chemotherapy for intimal sarcoma of inferior vena cava: A case report
Authors: Liao Haihong , Fang Yong , Li Da , Pan Yuefen , Niu Zhongfeng , Fu Tianhong , Wu Zhuoxuan , Sheng Jin , Dong Yong , Han Shuwen , Qi Quan , Liu Yulong 
Published: May 2024

Rationale:
Intimal sarcoma of inferior vena cava (IVC) is a rare soft tissue sarcoma with no typical symptoms and specific imaging features in the early stage, and there is a lack of standardized treatment and methods.

Patient concerns:
A 54-year-old female patient presented to Fenghua District People’s Hospital with a post-active cough and hemoptysis and was subsequently referred to our hospital.

Diagnoses:
The patient was pathologically diagnosed as intimal sarcoma of IVC complicating multiple intrapulmonary metastases. Chest CT revealed left lung malignant tumor with multiple intrapulmonary metastases; while enhanced upper abdominal CT showed cancer embolus of IVC with extension to right atrium and bilateral renal veins. Besides, hematoxylin and eosin staining suggested intimal sarcoma of veins. Immunohistochemical staining showed positivity for PD-L1, Ki-67, CD31, Desmin and ERG.

Interventions:
The patient initially received GT chemotherapy (gemcitabine injection + docetaxel). Then, immunotherapy (tislelizumab) was added based on the results of genetic testing (TP53 gene mutation).

Outcomes:
The disease was stabilized after receiving the treatment.

Lessons:
Given the lack of characteristic clinical manifestations in patients with intimal sarcoma of IVC, imaging examination combined with immunohistochemical index were helpful for diagnosis of intimal sarcoma of IVC. Furthermore, the combination of tislelizumab and GT chemotherapy was feasible in such patients with positive PD-L1 expression and TP53 mutation.
Predictive role of Naples prognostic score for survival in esophageal cancer: A meta-analysis
Authors: Guo Hongmei , Wang Ting 
Published: May 2024

Background:
To further clarify the predictive value of pretreatment Naples prognostic score (NPS), calculating based on the serum albumin concentration, total cholesterol level, neutrophil to lymphocyte ratio (NLR) and lymphocyte-to-monocyte ratio (LMR), among esophageal cancer patients based on available evidence.

Methods:
The PubMed, EMBASE, Web of Science and CNKI databases were searched up to December 1, 2023 for relevant studies. Overall survival (OS), progression-free survival (PFS) and cancer-specific survival (CSS) were endpoints and the hazard ratio (HR) with 95% confidence interval (CI) was combined to evaluate the predictive role of NPS for survival. Subgroup analysis based on pathological type and treatment were further conducted.

Results:
Ten retrospective studies with 2250 cases were included in our analysis. Pooled results demonstrated that higher pretreatment NPS predicted poorer OS (HR = 2.24, 95% CI: 1.57–3.20, P < .001), PFS (HR = 3.03, 95% CI: 1.84–4.98, P < .001) and CSS (HR = 2.90, 95% CI: 1.80–4.68, P < .001). Then subgroup analysis for the OS and PFS stratified by the pathological type (squamous cell carcinoma vs esophageal cancer) and treatment (surgery vs non-surgery) were further conducted, which showed similar results.

Conclusion:
Pretreatment NPS is significantly associated with prognosis in esophageal cancer and higher NPS predicts worse survival among patients with esophageal cancer.
Application value of real-time 3D speckle tracking imaging in left atrial function evaluation of patients with paroxysmal atrial fibrillation
Authors: Wang Yufeng , Bai Dong , Lu Xiaojun , Hou Haijun , Liang Lei 
Published: May 2024

Objective:
To evaluate left atrial volume and function in patients with paroxysmal atrial fibrillation (AF) combined with left atrial appendage thrombosis and patients with paroxysmal AF without left atrial appendage thrombosis by 3-dimensional speckle tracking imaging (3D-STI), and to explore the application value of this set of parameters in the evaluation of left atrial function in patients with paroxysmal AF.

Materials and Methods:
A total of 40 patients with paroxysmal AF admitted from December 2018 to December 2020 were selected as the observation group. All patients with paroxysmal AF in the observation group underwent transesophageal echocardiography. According to the presence of left atrial appendage thrombosis, the patients were divided into the AF without thrombosis group (24 cases) and the AF with thrombosis group (16 cases). Thirty normal people were selected as control group who were chosen as having no heart-related disease. The left atrial volume parameters (Left atrial maximum volume LAVmax, Left atrial minimum volume LAVmin, Left atrial volume before atrial contraction LAVpre-A, Left atrial stroke volume LAEV), left atrial ejection fraction (LAEF) and left atrial strain parameters (Left atrial reservoir longitudinal strain LASr, Left atrial conduit longitudinal strain LAScd, Left atrial contraction longitudinal strain LASct, Left atrial reservoir circumferential strain LASr-c, Left atrial conduit circumferential strain LAScd-c, Left atrial contraction circumferential strain LASct-c) of the 3 groups were measured by 3D-STI.

Results:
With the progression of paroxysmal AF, the left atrial volume increased, and the reservoir, conduit and contractile function were damaged. The left atrial volume continued to increase, and the reservoir, conduit and contractile function further decreased significantly in patients with AF combined with left atrial appendage thrombosis. LAEF was positively correlated with LASr and LASr_c.

Conclusion:
Real-time 3-dimensional spot tracking imaging (3D-STI) can evaluate the changes in left atrial volume and function in patients with paroxysmal AF, and has a certain reference value for clinical judgment of disease progression and prognosis.
Investigation of postoperative erectile dysfunction in colorectal surgery patients and comparison of results
Authors: Uçaner Burak , Buldanli Mehmet Zeki , Çimen Şebnem , Çiftçi Mehmet Sabri , Demircioğlu Mehmet Mert , Kaymak Şahin , Hançerlioğullari Oğuz 
Published: May 2024

Background:
Although surgical treatment is curative for colorectal cancers, erectile dysfunction (ED) is one of the complications that affect the patient quality of life. The present study aimed to evaluate sexual dysfunction in patients who underwent anterior resection (AR) and low AR (LAR) surgery secondary to rectosigmoid pathologies in our clinic, to analyze the effective variables, and to compare the results.

Methods:
In the retrospectively designed study, male patients who underwent surgery for malignancy or other surgical pathologies in the General Surgery Clinic between January 2017 and December 2022 were examined. Female gender, patients under 18 years of age, and patients who refused to participate in the study were excluded.

Results:
The high age of the patient increased the risk of severe ED in the postoperative period. However, surgical technique, alcohol use, American Society of Anesthesiologists (ASA) score, and Clavien-Dindo class were not determinants in the presence of severe ED.

Conclusion:
ED is an emerging medical problem that affects patients who undergo colorectal surgery adversely both in social and psychological aspects. Discussions on the issue are still ongoing. Clinicians’ concerns can be addressed in the future as the number of prospectively designed studies involving more homogeneous and larger populations increases.
Unpacking the Paradox
Authors: Englund Heather M. , Janssen Erika , Morgan Lindsay , Schroeder Grayson 
Published: May 2024

Background:
Awareness about existing health disparities affecting sexual minorities remains insufficient, and nursing professionals often lack self-awareness about their biases and assumptions concerning lesbian, gay, bisexual, transgender, or queer/questioning (LGBTQ) individuals.

Purpose:
To explore how exposure to the LGBTQ community, during both classroom and clinical experiences, relates to nursing students’ confidence in providing culturally congruent care to this group.

Methods:
This nonexperimental correlational study occurred at a Midwest 4-year public university, involving final-semester baccalaureate nursing students who completed demographic and educational preparation surveys regarding their confidence in providing health care to the LGBTQ population.

Results:
Results indicate that participants with no direct care experience were more confident in their communication skills and culturally congruent patient care for sexual minorities compared to those exposed to sexual minorities in clinical settings.

Conclusions:
Nursing students’ perceptions and experiences in delivering culturally congruent health care to sexual minorities provide an interesting perspective for examining the Dunning-Kruger effect.
Affective Responses to Acute Exercise: A Meta-Analysis of the Potential Beneficial Effects of a Single Bout of Exercise on General Mood, Anxiety, and Depressive Symptoms
Authors: Weinstein Ali A. , van Aert Robbie C.M. , Donovan Kiersten , Muskens Lotte , Kop Willem J. 
Published: May 2024

ABSTRACT

Objective
Acute exercise elicits various biobehavioral and psychological responses, but results are mixed with regard to the magnitude of exercise-induced affective reactions. This meta-analysis examines the magnitude of general mood state, anxiety, and depressive symptom responses to acute exercise while exploring exercise protocol characteristics and background health behaviors that may play a role in the affective response.

Methods
A total of 2770 articles were identified from a MEDLINE/PubMed search and an additional 133 articles from reviews of reference sections. Studies had to have measured general mood before the acute exercise bout and within 30 minutes after exercise completion. Effect sizes were estimated using Hedges' g, with larger values indicating improvement in the outcome measure.

Results
A total of 103 studies were included presenting data from 4671 participants. General mood state improved from preexercise to postexercise (g = 0.336, 95% confidence interval [CI] = 0.234–0.439). Anxiety (g = 0.497, 95% CI = 0.263–0.730) and depressive symptoms (g = 0.407, 95% CI = 0.249–0.564) also improved with exercise. There was substantial and statistically significant heterogeneity in each of these meta-analyses. This heterogeneity was not explained by differences in participants’ health status. Meta-regression analyses with potential moderators (intensity of exercise, mode of exercise, usual physical activity level, or weight status of participants) also did not reduce the heterogeneity.

Conclusion
This meta-analysis shows significantly improved general mood, decreased anxiety, and lower depressive symptoms in response to an acute bout of exercise. There was substantial heterogeneity in the magnitude of the effect sizes, indicating that additional research is needed to identify determinants of a positive affective response to acute exercise.
The Adaptiveness of Emotion Regulation Variability and Interoceptive Attention in Daily Life
Authors: Ma Chenyue , Wang Xiaoqin , Blain Scott D. , Tan Yafei 
Published: May 2024

ABSTRACT

Objective
In daily life, we must dynamically and flexibly deploy strategies to regulate our emotions, which depends on awareness of emotions and internal bodily signals. Variability in emotion-regulation strategy use may predict fewer negative emotions, especially when people pay more attention to their bodily states—or have greater “interoceptive attention” (IA). Using experience sampling, this study aimed to test whether IA predicts variability in strategy use and whether this variability and IA together predict negative affect.

Methods
University student participants (n = 203; 165 females; M
age = 20.68, SDage = 1.84) completed trait questionnaires and reported state levels of IA, emotional awareness, negative affect, and emotion-regulation strategies, seven times daily for 1 week.

Results
State IA significantly predicted between-strategy variability, which was mediated by emotional awareness (indirect effect = 0.002, 95% confidence interval = <0.001–0.003). Between-strategy variability was associated with lower negative affect, particularly when individuals had higher state IA (simple slope = −0.83, t = −5.87, p < .001) versus lower IA (simple slope = −0.31, t = −2.62, p = .009).

Conclusions
IA appears to facilitate adaptative emotion regulation and help alleviate negative affect. Findings underscore the key roles of IA and emotion-regulation flexibility in mental health.
Endogenous ZAP affects Zika virus RNA interactome
Authors: Sabir Ahmad Jawad , Khanh Le Nguyen Phuong , Singh Prince Pal , Karniychuk Uladzimir 
Published: May 2024

AbstractOne of the most recent advances in the analysis of viral RNA–cellular protein interactions is the Comprehensive Identification of RNA-binding Proteins by Mass Spectrometry (ChIRP-MS). Here, we used ChIRP-MS in mock-infected and Zika-infected wild-type cells and cells knockout for the zinc finger CCCH-type antiviral protein 1 (ZAP). We characterized “ZAP-independent” and “ZAP-dependent” cellular protein interactomes associated with flavivirus RNA and found that ZAP affects cellular proteins associated with Zika virus RNA. The ZAP-dependent interactome identified with ChIRP-MS provides potential ZAP co-factors for antiviral activity against Zika virus and possibly other viruses. Identifying the full spectrum of ZAP co-factors and mechanisms of how they act will be critical to understanding the ZAP antiviral system and may contribute to the development of antivirals.
Residues 2-7 of α-synuclein regulate amyloid formation via lipid-dependent and -independent pathways
Authors: Dewison Katherine M. , Rowlinson Benjamin , Machin Jonathan M. , Crossley Joel A. , Thacker Dev , Wilkinson Martin , Ulamec Sabine M. , Khan G. Nasir , Ranson Neil A. , van Oosten-Hawle Patricija , Brockwell David J. , Radford Sheena E. 
Published: May 2024

AbstractAmyloid formation by α-synuclein (αSyn) occurs in Parkinson’s disease, multiple system atrophy, and dementia with Lewy bodies. Deciphering the residues that regulate αSyn amyloid fibril formation will not only provide mechanistic insight, but may also reveal new targets to prevent and treat disease. Previous investigations have identified several regions of αSyn to be important in the regulation of amyloid formation, including the non-amyloid-β component (NAC), P1 region (residues 36-42), and residues in the C-terminal domain. Recent studies have also indicated the importance of the N-terminal region of αSyn for both its physiological and pathological roles. Here, the role of residues 2-7 in the N-terminal region of αSyn are investigated in terms of their ability to regulate amyloid fibril formationin vitroandin vivo. Deletion of these residues (αSynΔN7) slows the rate of fibril formationin vitroand reduces the capacity of the protein to be recruited by wild-type (αSynWT) fibril seeds, despite cryo-EM showing a fibril structure consistent with those of full-length αSyn. Strikingly, fibril formation of αSynΔN7 is not induced by liposomes, despite the protein binding to liposomes with similar affinity to αSynWT. ACaenorhabditis elegansmodel also showed that αSynΔN7::YFP forms few puncta and lacks motility and lifespan defects typified by expression of αSynWT::YFP. Together, the results demonstrate the involvement of residues 2-7 of αSyn in amyloid formation, revealing a new target for the design of amyloid inhibitors that may leave the functional role of the protein in membrane binding unperturbed.Significance StatementAmyloid formation of α-synuclein (αSyn) is associated with Parkinson’s disease. Attempts to target αSyn aggregation to treat synucleinopathies, thus far, have been unsuccessful. A better understanding of residues that regulate amyloid formation may reveal new targets for therapeutics. Here, six residues at the N-terminus of αSyn are identified as regulators of amyloid formation. Deletion of these residues slows lipid-independent assembly, ablates lipid-dependent amyloid formationin vitro, and prevents aggregation and its associated cellular toxicityin vivo. Importantly, these residues are not necessary for binding to synthetic membranes. The work reveals a new target for the prevention of synucleinopathies by disfavouring aggregation without perturbing membrane binding, a property considered to be essential for the physiological function of αSyn at the synapse.
Anti-corrosive superhydrophobic coatings for reinforcement protection: recycling of concrete garbage
Authors: Wen Xiaohu , Cao Xiangkang , Ma Xiao-ze , Zhang Zefan , Dong Zehua 
Published: May 2024

Purpose
The purpose of this paper was to prepare a ternary hierarchical rough particle to accelerate the anti-corrosive design for coastal concrete infrastructures.

Design/methodology/approach
A kind of micro-nano hydrophobic ternary microparticles was fabricated from SiO2/halloysite nanotubes (HNTs) and recycled concrete powders (RCPs), which was then mixed with sodium silicate and silane to form an inorganic slurry. The slurry was further sprayed on the concrete surface to construct a superhydrophobic coating (SHC). Transmission electron microscopy and energy-dispersive X-ray spectroscopy mappings demonstrate that the nano-sized SiO2 has been grafted on the sub-micron HNTs and then further adhered to the surface of micro-sized RCP, forming a kind of superhydrophobic particles (SiO2/HNTs@RCP) featured of abundant micro-nano hierarchical structures.

Findings
The SHC surface presents excellent superhydrophobicity with the water contact angle >156°. Electrochemical tests indicate that the corrosion rate of mild steel rebar in coated concrete reduces three-order magnitudes relative to the uncoated one in 3.5% NaCl solution. Water uptake and chloride ion (Cl-) diffusion tests show that the SHC exhibits high H2O and Cl- ions barrier properties thanks to the pore-sealing and water-repellence properties of SiO2/HNTs@RCP particles. Furthermore, the SHC possesses considerable mechanical durability and outstanding self-cleaning ability.

Originality/value
SHC inhibits water uptake, Cl- diffusion and rebar corrosion of concrete, which will promote the sustainable application of concrete waste in anti-corrosive concrete projects.
More is better? The role of strategic data management in a lean manufacturing process
Authors: Yang Chao-Lung , Chen Chun-Fu , Chen Jin-Yu , Sutrisno Hendri 
Published: May 2024

Purpose
Lean manufacturing has been pivotal in emphasizing the reduction of cycle times, minimizing manufacturing costs and diminishing inventories. This research endeavors to formulate a lean data management paradigm, through the design and execution of a strategic edge-cloud data governance approach. This study aims to discern anomalous or unforeseen patterns within data sets, enabling an efficacious examination of product shortcomings within manufacturing processes, while concurrently minimizing the redundancy associated with the storage, access and processing of nonvalue-adding data.

Design/methodology/approach
Adopting a lean data management framework within both edge and cloud computing contexts, this study ensures the preservation of significant time series sequences, while ascertaining the optimal quantity of normal time series data to retain. The efficacy of detected anomalous patterns, both at the edge and in the cloud, is assessed. A comparative analysis between traditional data management practices and the strategic edge-cloud data governance approach facilitates an exploration into the equilibrium between anomaly detection and space conservation in cloud environments for aggregated data analysis.

Findings
Evaluation of the proposed framework through a real-world inspection case study revealed its capability to navigate alternative strategies for harmonizing anomaly detection with data storage efficiency in cloud-based analysis. Contrary to the conventional belief that retaining comprehensive data in the cloud maximizes anomaly detection rates, our findings suggest that a strategic edge-cloud data governance model, which retains a specific subset of normal data, can achieve comparable or superior accuracy with less normal data relative to traditional methods. This approach further demonstrates enhanced space efficiency and mitigates various forms of waste, including temporal delays, storage of noncontributory normal data, costs associated with the analysis of such data and excess data transmission.

Originality/value
By treating inspected normal data as nonvalue-added, this study probes the intricacies of maintaining an optimal balance of such data in light of anomaly detection performance from aggregated data sets. Our proposed methodology augments existing research by integrating a strategic edge-cloud data governance model within a lean data analytical framework, thereby ensuring the retention of adequate data for effective anomaly detection.