bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mental health–related service and medicine use among a cohort of urban Aboriginal children and young people: Data linkage study
Authors: Young Christian , Burgess Leonie , Falster Kathleen , Zoega Helga , Banks Emily , Clapham Kathleen , Woolfenden Sue , Cutmore Mandy , Williamson Anna 
Published: May 2024

Objective: The objective was to describe mental health service and psychotropic medicine use among a cohort of Aboriginal young people and quantify their relation to sociodemographic, family and health factors. Methods: In a prospective cohort study with data linkage, 892 Aboriginal children aged 0–17 years living in urban and regional areas of New South Wales, Australia, were included. We assessed mental health–related service use, paediatric service use and psychotropic medicine dispensing claims covered by the Australian Government Medicare Benefits Schedule and the Pharmaceutical Benefits Scheme from July 2012 to June 2017. Results: Most children (71%) did not have a record of mental health service or psychotropic medication use. 18.7% had ⩾1 mental health–related service claim; 26.7% had ⩾1 paediatric service claim; and 20.3% had ⩾1 psychotropic medicine dispensing claim. General practitioner services were the most accessed mental health–related service (17.4%) and 12.7% had been dispensed attention-deficit hyperactivity disorder medicines. Child characteristics associated with treatment included emotional and behavioural problems (prevalence ratio: 1.97, 95% confidence interval = [1.46, 2.64] for mental health services; prevalence ratio: 2.87, 95% confidence interval = [2.07, 3.96] for medicines) and risky behaviour (prevalence ratio: 1.56, 95% confidence interval = [1.12, 2.16] for mental health services; prevalence ratio: 2.28, 95% confidence interval = [1.54, 3.37] for medicines). Parent-related factors included chronic illness (prevalence ratio: 1.42, 95% confidence interval = [1.03, 1.95] for mental health services; prevalence ratio: 2.00, 95% confidence interval = [1.49, 2.69] for medicines) and functional limitations (prevalence ratio: 1.61, 95% confidence interval = [1.16, 2.24] for mental health services; prevalence ratio: 1.86, 95% confidence interval = [1.34, 2.59] for medicines). Conclusions: Most Aboriginal children and young people did not have claims for mental health services or medicines. Aboriginal children with emotional and behavioural problems, or parents with health problems were more likely to have mental health service or medicine claims.
Paying with Money or Paying with Points: How Variable Versus Fixed Exchange Rates Influence Loyalty Point Redemption
Authors: Chun So Yeon , Hamilton Rebecca W. 
Published: May 2024

Although research examining loyalty point redemption has focused almost exclusively on fixed exchange rates between points and money (e.g., 100 points = $1), variable exchange rates are observed frequently in practice (e.g., 100 points might equate to more or less than $1, depending on the monetary price and the required points for a flight redemption within the continental United States). Such variable rates are particularly common in loyalty programs in the hospitality industry. In this research, the authors show that the stability of the exchange rate—whether the exchange rate is fixed or variable across offers—systematically influences point redemption. Consumers are less likely to redeem loyalty points and instead spend money when they observe a variable exchange rate between money and points than when they observe a fixed exchange rate, even when the average value of points is the same. This effect is demonstrated in a series of studies across contexts, including an incentive-compatible retail loyalty program and a hotel loyalty program. The findings show that a variable point exchange rate induces more optimism than a fixed exchange rate, reducing point redemption. This effect is moderated by individual differences in optimism and by point expiration date. The authors conclude by discussing the implications for managers of loyalty programs and for consumers. This manuscript was submitted to JMR before Rebecca Hamilton’s appointment as Editor in Chief. The editor team that began the review process, Sachin Gupta and Vikas Mittal, finished the review process and final acceptance, per the AMA policy on submissions by journal editors.
WIC Peer Counselors Support Breastfeeding Among WIC Participants
Authors: Wagner Lisa , Phillips Carolyn A. 
Published: May 2024

Background: The Special Supplemental Nutrition Program for Women, Infants, and Children, also known as WIC, is associated with improved health outcomes for participants. The role of WIC Peer Counselors was created to support breastfeeding among WIC participants. Objective: This Naturalistic Inquiry study explored the perceptions and experiences of 9 WIC Peer Counselors located in Southeast Texas. Methods: The WIC Peer Counselors were recruited via purposive and snowball sampling and participated in semi-structured face-to-face interviews. Data collection, analysis, and trustworthiness adhered to established guidelines. Results: Study findings revealed the novel approaches the WIC Peer Counselors used to encourage, initiate, support, and sustain WIC participants’ breastfeeding, including using tools of their craft, involving and educating family members, making themselves accessible 24/7, and identifying the need for equipment and supplies. Conclusions: The WIC Peer Counselors’ understanding of the breastfeeding culture of their WIC clients and their unique ability to establish and maintain rapport with them make WIC Peer Counselors ideally suited resources to meet the WIC goal of increasing breastfeeding and thereby improving the health of the nation. Health care providers should recognize the valuable, yet unrecognized and underutilized, contributions of WIC Peer Counselors and consider referring pregnant and postpartum dyads to WIC for breastfeeding education and support.
Compression therapy after endovenous laser ablation: Patient compliance and impact on clinical outcome
Authors: Dietrich Carmen K , Stucker Markus , Hartmann Karsten , Hirsch Tobias , Mattausch Thomas , Wenzel Hans-Christian , Zollmann Philipp , Veltman Jürgen , Weiler Thomas K , Lengfellner Guido , Müller Lars , Pannier Felizitas , Cussigh Christiane , Uhlmann Lorenz , Müller-Christmann Christine 
Published: May 2024

Objectives This study aimed to investigate the impact of post-interventional compression therapy on clinical outcomes after endovenous laser ablation (EVLA) of incompetent saphenous veins. Methods This prospective, controlled, multicenter study in Germany involved 493 varicose vein patients followed-up for 6 months. Results Compression therapy significantly reduced symptoms compared to no compression (VCSS: 1.4 ± 1.6 vs 2.2 ± 2.2; p = .007). Post-interventional therapy duration of up to 14 days was found to be most effective for improving patient-reported disease severity ( p < .001) and higher quality of life ( p = .001). Patient compliance was high (82%), and non-compliance was linked to worse disease severity (VCSS 1.4 ± 1.5 vs 2.1 ± 2.3, p = .009). Conclusion In conclusion, post-interventional compression therapy is beneficial by reducing symptoms and improving quality of life. High patient compliance with the therapy is observed, and non-compliance is associated with worse disease severity.
Hydrological evolution and differential response of the eco-environment recorded in Lake Maozangtianchi, eastern Qilian Mountains, over the last 900 years
Authors: Guo Shilong , Wu Duo , Wang Tao , Chen Lin , Li Youmo , Wang Tianxiao , Shao Shuai , Zhou Aifeng 
Published: May 2024

The Qilian Mountains (QLM) act as an “ecological security barrier” in western China, impacting the downstream ecosystems and water resource utilization. However, the hydrological evolution of the QLM during the last millennium remains controversial, and their ecological response to climate change is poorly understood. We present a pH record based on the brGDGTs (branched glycerol dialkyl glycerol tetraethers) of a 14C-dated sediment core from Lake Maozangtianchi in the QLM. We combined this record with element contents determined by scanning XRF and grain size to reconstruct the summer monsoon precipitation variability over the last 900 years. We also reconstructed the history of eco-environmental changes from the total n-alkane contents. On centennial scales, local precipitation exhibited peaks during the intervals of 1100‒1300 CE and 1750‒2000 CE, as well as between 1400‒1750 CE. Additionally, abrupt decreases in precipitation occurred during the transition from the Medieval Warm Period (MWP) to the Little Ice Age (LIA) (1300‒1400 CE). This pattern coherent with other hydroclimatic records from the monsoonal margin of northern China, likely resulted from the combined impact of the El Niño‒Southern Oscillation on tropical Pacific sea-surface temperatures and the meridional shift of the Intertropical Convergence Zone. In addition, a coupled relationship between plant biomass in the Lake Maozangtianchi watershed and fluctuations in monsoon precipitation was observed, with higher plant biomass during 1100‒1200 CE, 1750‒1900 CE, and 1950‒2000 CE, and lower biomass during 1200‒1400 CE and 1900‒1950 CE. However, during 1400‒1750 CE, plant biomass exhibited a minor increasing trend, deviating from its usual correlation with monsoon precipitation. Despite precipitation usually being the primary climatic factor influencing plant biomass in the QLM, during the LIA, nutrients transported by dust and decreased evapotranspiration became pivotal in bolstering plant growth. Our research emphasizes the significant moderating effects of exogenic dust on vegetation changes in alpine ecosystems.
Serum LINC00339 is a promising biomarker for prognosis prediction of nasopharyngeal carcinoma
Authors: Qi Xunjing , Yuan Lijuan , Wu Zhijiao , Tian Yuanyuan 
Published: May 2024

Background Long non-coding RNAs (lncRNAs) in serum were useful and promising biomarkers for diagnostic and prognostic application. Herein, we investigated the serum lncRNA LINC00339 expression and its role in nasopharyngeal carcinoma. Methods In this study, we recruited a cohort of 129 nasopharyngeal carcinoma patients, 68 patients with nasopharyngitis, and 80 healthy controls. Serum LINC00339 levels were measured by reverse transcription-quantitative polymerase chain reaction. Receiver operating characteristic (ROC) and Kaplan–Meier curve analyses were conducted to evaluate th e clinical role of LINC00339. The effects of linc00339 on cellular activities were measured using CCK-8 and Transwell assays. Results We observed that serum LINC00339 expression was upregulated in nasopharyngeal carcinoma patients and closely associated with tumor node metastasis stage, lymph node metastasis, and overall survival rate. Meanwhile, ROC analysis showed serum LINC00339 had diagnostic value to distinguish nasopharyngeal carcinoma patients from healthy individuals and nasopharyngitis patients. Silencing of LINC00339 could repress cellular behaviors by targeting miR-152. Conclusion This study clarified that LINC00339 was upregulated in nasopharyngeal carcinoma, and that serum LINC00339 may act as a diagnostic or prognostic marker, and a hopeful therapeutic target for patients with nasopharyngeal carcinoma.
Uncovering novel therapeutic targets in glucose, nucleotides and lipids metabolism during cancer and neurological diseases
Authors: Jovičić Snežana M 
Published: May 2024

Background Cell metabolism functions without a stop in normal and pathological cells. Different metabolic changes occur in the disease. Cell metabolism influences biochemical and metabolic processes, signaling pathways, and gene regulation. Knowledge regarding disease metabolism is limited. Objective The review examines the cell metabolism of glucose, nucleotides, and lipids during homeostatic and pathological conditions of neurotoxicity, neuroimmunological disease, Parkinson’s disease, thymoma in myasthenia gravis, and colorectal cancer. Methods Data collection includes electronic databases, the National Center for Biotechnology Information, and Google Scholar, with several inclusion criteria: cell metabolism, glucose metabolism, nucleotide metabolism, and lipid metabolism in health and disease patients suffering from neurotoxicity, neuroinflammation, Parkinson’s disease, thymoma in myasthenia gravis. The initial number of collected and analyzed papers is 250. The final analysis included 150 studies out of 94 selected papers. After the selection process, 62.67% remains useful. Results and Conclusion A literature search shows that signaling molecules are involved in metabolic changes in cells. Differences between cancer and neuroimmunological diseases are present in the result section. Our finding enables insight into novel therapeutic targets and the development of scientific approaches for cancer and neurological disease onset, outcome, progression, and treatment, highlighting the importance of metabolic dysregulation. Current understanding, emerging research technologies and potential therapeutic interventions in metabolic programming is disucussed and highlighted.
Canadian Network for Mood and Anxiety Treatments (CANMAT) 2023 Update on Clinical Guidelines for Management of Major Depressive Disorder in Adults: Réseau canadien pour les traitements de l'humeur et de l'anxiété (CANMAT) 2023 : Mise à jour des lignes directrices cliniques pour la prise en charge du trouble dépressif majeur chez les adultes
Authors: Lam Raymond W. , Kennedy Sidney H. , Adams Camelia , Bahji Anees , Beaulieu Serge , Bhat Venkat , Blier Pierre , Blumberger Daniel M. , Brietzke Elisa , Chakrabarty Trisha , Do André , Frey Benicio N. , Giacobbe Peter , Gratzer David , Grigoriadis Sophie , Habert Jeffrey , Ishrat Husain M. , Ismail Zahinoor , McGirr Alexander , McIntyre Roger S. , Michalak Erin E. , Müller Daniel J. , Parikh Sagar V. , Quilty Lena S. , Ravindran Arun V. , Ravindran Nisha , Renaud Johanne , Rosenblat Joshua D. , Samaan Zainab , Saraf Gayatri , Schade Kathryn , Schaffer Ayal , Sinyor Mark , Soares Claudio N. , Swainson Jennifer , Taylor Valerie H. , Tourjman Smadar V. , Uher Rudolf , van Ameringen Michael , Vazquez Gustavo , Vigod Simone , Voineskos Daphne , Yatham Lakshmi N. , Milev Roumen V. 
Published: May 2024

Background The Canadian Network for Mood and Anxiety Treatments (CANMAT) last published clinical guidelines for the management of major depressive disorder (MDD) in 2016. Owing to advances in the field, an update was needed to incorporate new evidence and provide new and revised recommendations for the assessment and management of MDD in adults. Methods CANMAT convened a guidelines editorial group comprised of academic clinicians and patient partners. A systematic literature review was conducted, focusing on systematic reviews and meta-analyses published since the 2016 guidelines. Recommendations were organized by lines of treatment, which were informed by CANMAT-defined levels of evidence and supplemented by clinical support (consisting of expert consensus on safety, tolerability, and feasibility). Drafts were revised based on review by patient partners, expert peer review, and a defined expert consensus process. Results The updated guidelines comprise eight primary topics, in a question-and-answer format, that map a patient care journey from assessment to selection of evidence-based treatments, prevention of recurrence, and strategies for inadequate response. The guidelines adopt a personalized care approach that emphasizes shared decision-making that reflects the values, preferences, and treatment history of the patient with MDD. Tables provide new and updated recommendations for psychological, pharmacological, lifestyle, complementary and alternative medicine, digital health, and neuromodulation treatments. Caveats and limitations of the evidence are highlighted. Conclusions The CANMAT 2023 updated guidelines provide evidence-informed recommendations for the management of MDD, in a clinician-friendly format. These updated guidelines emphasize a collaborative, personalized, and systematic management approach that will help optimize outcomes for adults with MDD.
Current Advances in Artificial Intelligence in the Field of Aesthetic Surgery and Breast Augmentation: Short Review
Authors: Supramaniam Senthil Kumar 
Published: May 2024

Study design: This review is structured as a systematic analysis of the literature to evaluate the impacts of artificial intelligence (AI) on the field of plastic surgery, with a focus on breast augmentation and aesthetic surgical procedures. Key areas of exploration include advancements in machine-learning techniques relevant to plastic surgery, the integration of AI into preoperative planning processes, and the historical evolution of AI in aesthetic surgery. The review also systematically assesses current AI tools specifically developed for breast augmentation, such as 3D imaging and predictive analytics, to understand their efficacy and role in clinical practice. Objective: This article explores the current state and future prospects of AI in plastic surgery, with a focus on breast augmentation and aesthetic procedures. Emphasis is placed on the benefits, challenges, and the imperative for collaborative efforts in the integration of AI technologies. Methods: Advancements in machine-learning algorithms and AI technologies are examined for their potential in automating the assessment and enhancement of surgical skills. The role of AI in facilitating objective evaluations in aesthetic surgery is discussed, addressing challenges such as the lack of standardized training datasets and integration issues. The importance of mitigating potential biases introduced by AI to ensure objectivity in patient assessments is highlighted. Results: The article discusses the historical evolution of AI, from Alan Turing’s conceptualization to contemporary applications in aesthetic surgery. Artificial intelligence’s ability to analyze vast patient datasets is explored, showcasing its potential for offering personalized treatment recommendations and improving accuracy over time. Specific AI tools for breast augmentation, including Canfield Mirror, QuantifiCare LifeViz Infinity Pro, Crisalix, BreastGAN, Arbrea Breast Software (ABS), and Deep Surface AI, are examined in detail, emphasizing their advantages and drawbacks. Conclusions: Evaluation of clinical photography techniques, relying on specific hardware, is presented, with consideration given to the potential of AI-based illumination systems to enhance consistency in preoperative images. The review concludes by envisioning the transformative future of AI in aesthetic surgery, considering its untapped potential in diagnostic imaging, personalized treatment plans, and enhanced surgical precision through integration with virtual and augmented reality. Despite challenges, the promises of AI in personalized treatments, precise patient care, and improved surgical assistance suggest a transformative future for plastic surgery, contingent on addressing current concerns. Collaborative efforts are deemed essential for the successful implementation of AI technologies in the field.
Effects of rotational speed on transient cooling performance of nozzle spray with liquid nitrogen in a rotor-stator cavity
Authors: Yang Xuesen , Zhao Wei , Zhang Binglong , Ren Sanqun , Xiang Xiaorong , Zhao Qingjun 
Published: May 2024

This paper presents the results of an experimental investigation into the cooling performance of a rotor-stator cavity with liquid nitrogen spraying. The experiments were conducted under varying rotational Reynolds numbers ranging from 1.70 × 106 to 5.12 × 106. The effects of rotational speed on temperature drop rate are studied and compared in detail, as well as the heat transfer coefficient distribution. Sufficient data, such as heat flux, injection rate, and injection pressure, were collected to provide a basis for further study in explaining the spray and evaporation over the cavity. It was found that the cooling performance of the rotating disc is strongly affected by the rotational speed. The short-term period exhibits a peak cooling rate of 14°C/s, in contrast to the sustained cooling rate during the spray process at rotational speeds of 500r/min, which amounts to 0.9°C/s. The occurrence of cavitation and evaporation within the nozzle results in a reduction of flow coefficient and fluctuation of the injection differential pressure. The transient cooling performance is well-explained by the temperature changes and cooling-down time under different rotational speeds. The analysis of the heat transfer coefficient is further enhanced through an evaluation of the convective and conductive heat transfer rates using a one-dimensional theoretical approach. The average temperature of the disc is expected to decrease by 100°C within a time frame no longer than 120 s. Additionally, after a duration of 120 s, the average heat transfer rate on the cold side is anticipated to surpass 8000 W/(m·K).
Comprehensive Analysis of the Immunosuppressive Function of Regulatory T Cells in Human Hepatocellular Carcinoma Tissues
Authors: Ge Junwei , Chen Junjun , Shen Qiong , Zheng Xiao , Chen Xuemin , Shi Liangrong , Chen Lujun , Xu Bin 
Published: May 2024

Background Immune-based therapies are commonly employed to combat hepatocellular carcinoma (HCC). However, the presence of immune-regulating elements, especially regulatory T cells (Tregs), can dramatically impact the treatment efficacy. A deeper examination of the immune-regulation mechanisms linked to these inhibitory factors and their impact on HCC patient outcomes is warranted. Methods We employed multicolor fluorescence immunohistochemistry (mIHC) to stain Foxp3, cytokeratin, and nuclei on an HCC tissue microarray (TMA). Leveraging liver cancer transcriptome data from TCGA, we built a prognostic model focused on Treg-associated gene sets and represented it with a nomogram. We then sourced liver cancer single-cell RNA sequencing data (GSE140228) from the GEO database, selectively focusing on Treg subsets, and conducted further analyses, including cell-to-cell communication and pseudo-time trajectory examination. Results Our mIHC results revealed a more substantial presence of Foxp3+Tregs in HCC samples than in adjacent normal tissue samples ( P < .001). An increased presence of Foxp3+Tregs in HCC samples correlated with unfavorable patient outcomes ( HR = 1.722, 95% CI:1.023-2.899, P = .041). The multi-factorial prognosis model we built from TCGA liver cancer data highlighted Tregs as a standalone risk determinant for predicting outcomes ( HR = 3.84, 95% CI:2.52-5.83, P < .001). Re-analyzing the scRNA-seq dataset (GSE140228) showcased distinctive gene expression patterns in Tregs from varying tissues. Interactions between Tregs and other CD4+T cell types were predominantly governed by the CXCL13/CXCR3 signaling pathway. Communication pathways between Tregs and macrophages primarily involved MIF-CD74/CXCR4, LGALS9/CD45, and PTPRC/MRC1. Additionally, macrophages could influence Tregs via HLA-class II and CD4 interactions. Conclusion An elevated presence of Tregs in HCC samples correlated with negative patient outcomes. Elucidating the interplay between Tregs and other immune cells in HCC could provide insights into the modulatory role of Tregs within HCC tissues.