bluuebunny/crossref_metadata_2025_split huggingface dataset:
(208) ENDOVASCULAR TREATMENT OF ERECTILE DYSFUNCTION
Authors: Redondo Maria Consuelo Conde , Velasco Javier , Castroviejo-Royo Fatima , Calvo Raul , Cuellar Luis , Herranz Ana , Martin Nicolas Sierrasesumaga , D'Angelo Giovanna , Escudero Jesus Calleja 
Published: June 2024

Abstract

Objectives
Endovascular treatments for refractory patients vasculogenic erectile dysfunction have increased in popularity, including angioplasty or stenting for insufficiency arterial. We attempted to validate whether dilation plus stenting of the pudendal arteries, as described for coronary arteries, is useful for the ED treatment.

Methods
We evaluated 6 patients diagnosed with ED due to arterial insufficiency
Inclusion criteria:
IIEF &lt; 10
ED refractory to oral pharmacotherapy and intracavernous prostaglandin
Diagnosis of stenosis or occlusion of pelvic and penile arteries: using penile Doppler (peak systolic velocity &lt; 30cm/) and confirmed by CT angiography.
Technique: 6-F sheath was placed at the origin of theinternal pudendal for selective angiography. Revascularization was indicated if the stenosis was &gt;50%. Balloon angioplasty drug coated from 2 to 5 mm. If the dilation was not satisfactory, a drug-eluting stent was implanted. The revascularization of bilateral lesions was performed in 2 stages. All patients were treated by the same operator.
Patients were premedicated with acetylsalicylic acid (100 mg/d). And then with tadalafil (5 mg/day) for 3 weeks
Technical success was ultimately defined by patency on angiography after successful deployment of a stent or of the dilation balloon.
Clinical success was defined as an improvement &gt;4 points on the IIEF, the ability to perform penetrative sex, or subjective improvement.of erectile function.

Results
The average age of our patients was 62 years. The follow-up time of 12 months. In one patient it was not posible dilate the problem artery.
In one patient the internal iliac had to be previously dilated with a stent.
Only one patient achieved improved erection helped with IPD5.

Conclusions
Data defend that angioplasty of the penile artery is safe and improves erectile function in 60% of patients with isolated penile artery stenosis.
Our results are very poor, not achieving the desired cost-effectiveness.

Conflicts of Interest
None.
(413) LINGUAL MUCOSAL GRAFT (LMG) FOR PENILE CURVATURES: OUR INITIAL EXPERIENCE
Authors: Pozo Dr Carmen , Kollitsch Dr Lisa , Mock Dr Karl , Marszalek Dr Martin 
Published: June 2024

Abstract

Objectives
Penile curvatures (PC) exceeding 60 degrees typically require surgical treatment. Surgical approaches involving plaque incision/excision with grafting are preferred in these cases to avoid penile shortening. Buccal mucosa graft (BMG), particularly Lingual Mucosa Graft (LMG), is not typically emphasized in many review articles, and clinical series remain limited. Our aim was to evaluate our initial cases with LMG in the treatment of PC.

Methods
From February 2022 until November 2022, three patients, reporting normal erectile function but with PC exceeding 60 degrees that interfered with sexual function, underwent plaque incision and grafting with LMG. Postoperative erectile function, penile deformity, and postoperative complications were assessed.

Results
Median age was 56 (SD ±14.2) years, with a median angle of deformity of 80° (SD ±15.3). One of the patients had a congenital penile curvature (CPC). Two patients reported Peyronie Disease (PD) with a median time since presentation of 3.5 years (range from 3-4). The mean follow-up was 12 months (range 11-20). No donor site complications were reported. De novo mild erectile dysfunction was reported by one patient, who responded to a low-dose phosphodiesterase type 5 inhibitor. One patient presented seven months after surgery an abnormal growth tissue at the graft site, which did not interfere with sexuality. Recurrent curvature was observed in two patients, with a median of 20 degrees (range 20-45). All patients reported satisfactory intercourse.

Conclusions
Although based on a small series, LMG appears to be a valuable substitute for the tunica albuginea in cases of PC. It is readily available without complications at the donor site. However, a larger number of patients is needed to draw any definitive conclusion related to the elasticity of the graft.

Conflicts of Interest
None.
(72) THE HABITS OF EUROPEAN UROLOGISTS IN THE FIELD OF CRYOPRESERVATION BEFORE UROLOGICAL CANCERS TREATMENT
Authors: Degraeve Dr Amandine 
Published: June 2024

Abstract

Objectives
Treatments against urogenital cancers frequently have fertility side-effects. The strategy to preserve fertility after oncologic treatments is still a matter of debate with a lack of evidence and international guidelines. The aim of this study is to investigate fertility preservation practices before urogenital cancers treatments and to compare national habits.

Methods
An online anonymous survey was submitted from January to June 2021 to 6 European urological societies. The 31-items questionnaire included questions about demography, habits of evaluation and management of fertility preservation in case of urogenital cancers treatments.

Results
228 urologists from six urological societies in five different countries (Belgium, The Netherlands, Luxembourg, France, Finland) filled out the survey.
Three quarter (74%; n = 166) usually propose a cryopreservation before orchidectomy. In case of oligo/azoo-spermia, the technique performed for the sperm extraction during orchidectomy varies among the sample: 70.5% (n=160) of the responders do not perform a Testicular Sperm Extraction (TESE) nor a Percutaneous Epididymal Sperm Aspiration (PESA).
The cryopreservation for prostate cancer treatments is never proposed in 48.17% (n = 105) of responders but conversely it is always proposed in 5.05% (n = 11).
The cryopreservation before bladder cancer treatments is not commonly proposed (67.5%, n = 154).

Conclusions
Our study showed variable country specific tendencies in terms of fertility preservation in the period of treatment of urological cancers. These differences seem to be related to national guidelines and recommendations. International guidelines are urgently needed in the field of fertility for urological cancer patients. It is of utmost importance to take a clear stance on the potential importance of the semen preservation before orchidectomy, TESE and PESA in the tumor-bearing testis during orchidectomy in case of azoospermia and semen preservation discussion for young patients.

Conflicts of Interest
No conflict of interest.
(183) A PILOT STUDY OF POST-VESTIBULECTOMY OPIOID USE FOLLOWING PRE-OPERATIVE VESTIBULAR LOW INTENSITY SHOCKWAVE THERAPY
Authors: Goldstein Sue W , Goldstein Dr Irwin 
Published: June 2024

Abstract

Objectives
Low intensity shockwave therapy (LiWST) is FDA-cleared for pain amelioration. We serendipitously observed that one patient trying to avoid vestibulectomy surgery for neuroproliferative vestibulodynia (NPV) by undergoing multiple vestibular LiWST treatments used very few narcotics post-vestibulectomy. As a result, we studied whether using pre-operative LiSWT would decrease post-operative opioid use in patients undergoing complete vestibulectomy for NPV.

Methods
Post-op opioid use among women who underwent complete vestibulectomy at our facility January 1, 2019 to June 30, 2021 was assessed based on patient’s recall of total oxycodone/acetaminophen tablets required within 30 days post-vestibulectomy. When possible, patients confirmed use by counting tablets remaining in the pill container. Women scheduled for vestibulectomy were included in the LiSWT study group if they agreed to undergo 3 vestibular LiSWT treatments immediately pre-operatively. Using the Urogold 100™MTS, LiSWT involved delivery of 1800 shocks to the vestibule per session, energy flux density 0.05-0.1 mJ/mm2, 3 Hz, membrane pressure 3. We compared post-op opioid use by women who did and did not undergo pre-operative LiSWT.

Results
Forty-five women (mean age 28 years) underwent complete vestibulectomy during the 30-month period. Twenty women (mean age 27 years) underwent pre-op LiSWT and 25 (mean age 29 years) did not. Post-op opioid use was obtained from all but 6 in the non-LiSWT group. Mean post-op opioid use was 22 +/- 10 (range 1-26) tablets in patients who underwent vestibular LISWT treatments; opioid side effects were restricted to constipation, sleepiness, and nausea. Mean post-operative opioid use was 47 +/- 13 (range 25-90) tablets in those without vestibular LiSWT; opioid side effects included constipation, nausea, fainting, drowsiness, fatigue, and blurred vision.

Conclusions
In this pilot study, pre-operative low intensity shockwave therapy decreased post-operative opioid use after complete vestibulectomy with vaginal advancement flap. While encouraging, more research is needed.

Conflicts of Interest
No conflicts of interest.
(185) SAFETY AND PRELIMINARY EFFICACY OF PHASE 1 TRIAL TARGETING HPV16 INFECTION AND CERVICAL LESIONS WITH INTERFERON-INDUCING VIRAL VECTOR DELNS/E6E7: A PLACEBO-CONTROLLED STUDY WITH 28 PATIENTS
Authors: Bayerle-Eder M M D , Fuchs C , Muster T , Nicolodi C , Groiss F , Wolzt M 
Published: June 2024

Abstract

Objectives
Human papillomavirus type 16 (HPV16) is a major causative agent of cervical cancer, necessitating the development of innovative therapeutic strategies. This Phase 1 clinical trial aimed to evaluate the safety and preliminary efficacy of a novel intervention against persistent HPV16 infection and associated cervical lesions, utilizing an interferon-inducing viral vector expressing tumor antigens (delNS/E6E7), in a placebo-controlled study involving 28 patients.

Methods
In this placebo-controlled Phase 1 trial, 28 participants with HPV16 infection and cervical lesions were randomly assigned in a 3:1 ratio to receive the interferon-inducing viral vector delNS/E6E7 or a placebo over a 12-week period. Safety assessments were conducted regularly throughout the trial, and efficacy was evaluated by monitoring changes in HPV16 infection and cervical lesion status.

Results
The intervention group, which received delNS/E6E7, exhibited a favorable safety profile, with only mild and moderate transient adverse events reported. No serious adverse events related to the treatment were observed. Early indications of efficacy, such as HPV 16 clearance and regression or stabilization of cervical lesions were observed. The 12 month period of the follow-up study is still ongoing.

Conclusions
Conclusion: In this placebo-controlled Phase 1 trial, the interferon-inducing viral vector delNS/E6E7 exhibited a favorable safety profile and early indications of efficacy for the treatment of HPV16 infection and associated cervical lesions. These findings emphasize the potential of this innovative treatment approach for HPV16-related cervical health issues and underscore the need for further investigation in larger, randomized, controlled trials.

Conflicts of Interest
F. Groiss, T. Muster and C. Nicolodi are working for the company, which is producing the immune therapy (Blue Sky GmbH, Vienna, Austria).
M. Bayerle-Eder is consultant of Blue Sky GmbH.
(146) ASSESSING SEXUAL IMPULSE DEVELOPMENT SKILLS USING THE TCS-A IN A GROUP OF ADOLESCENTS: RESULTS AND IMPLICATIONS FOR DESIGN AND EDUCATIONAL INTERVENTION
Authors: Buono Dr Gabriele , Chiapparino Dr Marco , Denegri Dr Martina , Caprile Cristina , Pastorino Sabrina , Sferrazzo Dr Francesco 
Published: June 2024

Abstract

Objectives
The objective is to know the current condition of adolescents in the province in order to build a project of affectivity and sexuality education according to a bottom-up approach, taking into account emerging needs. However, due to the numerical limitation, it is intended to reach a more representative sample in collaboration with the Regional School Office and the Liguria Health Authority.

Methods
The TCS-A test was administered anonymously to 40 two-year adolescents (first and second classes) of a technical high school in Imperia, including 27 malesand 13 females between the ages of 14 and 19. Data were analyzed using Jamovi software. The test assesses cognitive, relational, sexual, and self-identity-building developmental skills.

Results
The research found that the area of sexual drive development competence is the most deficient compared to the other areas (T=29.9): in particular, it is statistically significant that the mean of the overall factor decreases with increasing age (p=0.032; r=-0.296), consistent with class (p=0.026; r=-0.31). For the area of sexual drives, it is statistically significant that as age increases, the following decreases: coping with sexual drives (p=0.04; r=-0.28), pride related to sexual development (p=0.017, r=-0.335), guilt-free sexual experience (p=0.04; r=-0.281), and feeling of difficulty in having a romantic relationship (p=0.084, r=-0.281).

Conclusions
Respect to the other developmental competencies, the scores are within the average (±1sd), except for the personal identity construction competence (39.1), particularly the area of life satisfaction (34.5). Respect to the open-ended questions, it emerges that those who would like to engage in sexuality education, define it in a more complex way, and those who would not like to participate in a project links sexuality to the physical dimension alone. The needs could be: scientifically based knowledge about sexuality, inclusive sexuality education, and sexual and general well-being.

Conflicts of Interest
The authors declare no conflict of interest.
(411) PROJECT BRIDGE: LINKING AT-RISK INDIVIDUALS TO A SUITABLE PREVENTATIVE CARE BASED ON RISK LEVEL
Authors: Jozefík Dominik , Ballester-Arnal Prof Rafael , Briken Prof Peer , Klapilová Kateřina , Metenko Prof Jozef , Vaaranen-Valkonen Dr Nina , Rahm Christoffer 
Published: June 2024

Abstract

Objectives
Projekt BRIDGE is an international two-year research project, funded by the European Commission under the Internal Security Fund, aimed at developing and evaluating two anonymous online interventions for individuals with a sexual interest in minors searching and using CSAM in SurfaceWeb and DarkWeb that are tailored to participant's risk level of sexually offending.

Methods
Two interventions tested are: (1) MiBridge – a three-week, anonymous, online Motivational Interviewing intervention aiming to motivate high-risk participants to admit to treatment face-to-face as identified patients, and (2) ReDirection – a five-week, anonymous online cognitive behavioural self-help program intervention aiming to reduce sexual urges and behaviours regarding children in the group with low/medium risk participants. Within the project, MiBridge and ReDirection are translated into several European languages and tested for feasibility in the randomised pilot trial. Based on the results, revised versions are evaluated for efficacy, safety and appreciation in two pre-registered, multicenter, randomised and waitlist-controlled trials. Inclusion criteria for all trials: English-, Swedish-, Spanish-, Finish-, Czech-, Slovak- or German-speaking; 18 years or older; with sexual urges directed towards children and past six months use of CSAM.

Results
The project started from January 2023 till December 2024. Recruitment of participants for the pilot trial ran from 30.06.2023 to 12.09.2023, and recruitment of participants for the randomised controlled trial is running from 14.09.2023 to 21.04.2024. During the two months of piloting, 357 people expressed interest in joining the project, of which 152 people booked an initial interview, and 11 people subsequently graduated from the project (5 ReDirection; 6 MiBridge).

Conclusions
The project represents a pioneering effort to address the sensitive and challenging issue of CSAM innovatively by implementing intervention strategies to make treatment available to those at risk of committing a sexually motivated offence. Preliminary results of the recruitment strategies and the efficacy of the interventions of the randomised control trial will be presented as part of the conference presentation.

Conflicts of Interest
No conflicts of interest.
Unique presentation of acute neuro-Behçet’s disease involving a cytotoxic oedema core surrounded by vasogenic oedema
Authors: Yamashita Shohei , Fujimori Daiki , Igari Shigemoto , Yamamoto Yusuke , Mizuuchi Takahiro , Mori Hiroaki , Hayashi Haeru , Tahara Koichiro , Sawada Tetsuji 
Published: June 2024

ABSTRACT
A 53-year-old woman with recurrent stomatitis, genital ulcers, and folliculitis was admitted to Tokyo Medical University Hospital after experiencing visual disturbances for the past 2 weeks and a nonthrobbing headache for the past 3 days. She had also developed numbness in her left extremities. An ophthalmological examination revealed inflammatory changes in the eye. Cerebrospinal fluid analysis showed increased cell counts, protein, and interleukin-6 levels. Brain magnetic resonance imaging revealed multiple high signal intensities on T2-weighted/fluid-attenuated inversion recovery images of the pons and occipital and parietal lobes. The T2-weighted/fluid-attenuated inversion recovery high-signal-intensity lesion in the pons was hyperintense on diffusion-weighted imaging and hypointense on apparent diffusion coefficient mapping, suggesting cytotoxic oedema. Another high-signal-intensity lesion on T2-weighted/fluid-attenuated inversion recovery was isointense to hyperintense on diffusion-weighted imaging and hyperintense on apparent diffusion coefficient, indicating vasogenic oedema. The vasogenic oedema in the left occipital lobe contained a small core that was hyperintense on diffusion-weighted imaging and hypointense on apparent diffusion coefficient, suggesting cytotoxic oedema. The patient was diagnosed with acute neuro-Behçet’s disease and responded well to high-dose glucocorticoid and colchicine treatment. The present report emphasises that patients with acute neuro-Behçet’s disease may present with cytotoxic oedema in the pons and cerebral spheres. Further reports of similar cases would contribute to a better understanding of the role of cytotoxic oedema in the pathophysiology of neuro-Behçet’s disease and help elucidate the mechanisms underlying a unique presentation characterised by a central cytotoxic oedema core within vasogenic oedema.
A Severe and Prolonged Case of Ocular Monkeypox Without Systemic Manifestations
Authors: Shan Kevin , Montalvo-Toledo Lorena A. , Shifera Amde Selassie , Santiago Esteban A. 
Published: June 2024

Purpose:
The objective of this study was to present a rare case of prolonged and severe ocular monkeypox virus infection in the absence of systemic manifestations.

Methods:
This was a single case report.

Results:
A 60-year-old man, having been symptomatic for 9 days, presented with several umbilicated, ulcerated papules on the left cheek, left side of the nose, and left upper eyelid, along with marked follicular conjunctivitis and multiple conjunctival ulcerations. Two weeks after presentation, he developed an irregular, 360° circumferential opacity in the peripheral cornea that progressed to a large epithelial defect with corneal thinning. Although the initial eyelid lesions and conjunctivitis quickly resolved, the patient experienced nonresolving corneal inflammation manifest with peripheral corneal thinning, epithelial defects, and stromal keratitis. Four months after presentation, with the presumptive diagnosis of peripheral ulcerative keratitis, the patient was treated with intravenous steroids and immunosuppressive treatment, after which the ocular surface inflammation improved. However, the inflammation recurred 12 weeks later, and the patient developed severe perilimbal necrotizing conjunctivitis, followed by recurrence of ulcerated nodular eyelid lesions. Eight months after presentation, nucleic acid amplification tests from eyelid lesion swabs returned positive for nonvariola Orthopoxviruses, which led to the diagnosis of mpox. Within 2 weeks of beginning antiviral treatment with systemic tecovirimat and cidofovir and topical trifluridine, the eyelid lesions, conjunctivitis, and corneal inflammation resolved.

Conclusions:
We present an unusual and challenging case of ocular mpox with severe ocular surface inflammation including peripheral corneal thinning and epithelial defects, without systemic disease. Initiation of antiviral treatment resulted in a quick resolution of the ocular disease.
Evaluation of two-stage hepatectomy using portal vein embolization for colorectal liver metastasis: a retrospective nationwide cohort survey in Japan
Authors: Shimizu Takayuki , Aoki Taku , Ishizuka Mitsuru , Sakamoto Katsunori , Beppu Toru , Honda Goro , Kotake Kenjiro , Yamamoto Masakazu , Takahashi Keiichi , Endo Itaru , Hasegawa Kiyoshi , Itabashi Michio , Hashiguchi Yojiro , Kotera Yoshihito , Kobayashi Shin , Yamaguchi Tatsuro , Natsume Soichiro , Tabuchi Ken , Kobayashi Hirotoshi , Yamaguchi Kensei , Tani Kimitaka , Morita Satoshi , Miyazaki Masaru , Sugihara Kenichi , Ajioka Yoichi 
Published: June 2024

Introduction:
Two-stage hepatectomy (TSH) enables patients to undergo surgery for colorectal liver metastasis (CRLM), which one-stage hepatectomy cannot remove. Although the outcome of TSH has been reported, there is no original report from Japan. The aim of this retrospective study was to evaluate the outcome of TSH in Japanese patients with CRLM.

Methods:
The authors conducted a retrospective cohort study using the nationwide database that included clinical information of 12 519 patients treated with CRLM between 2005 and 2017 in Japan. The primary outcome measure was overall survival. The second outcome measure was progression-free survival. Fisher’s exact test, χ2 test and Mann–Whitney U test were conducted to examine an intergroup difference. Univariate and multivariate analyses were performed using Cox regression model. Survival analysis was performed by Kaplan–Meier method and log-rank test.

Results:
Of the database, 53 patients undergoing TSH using portal vein embolization (PVE) were identified and analyzed. Their morbidity and in-hospital mortality rates at the second hepatectomy were 26.4% and 0.0%. The mean observation period was 21.8 months. The estimated 1-, 3- and 5-year overall survival rate were 92.5%, 70.8% and 34.7%. Multivariate analyses showed that more than 10 liver nodules significantly increased the mortality risk by 4.2-fold (95% CI 1.224–14.99, P= 0.023). Survival analysis revealed that repeat hepatectomy for disease progression after TSH was superior to chemotherapy in overall survival (mean: 49.6 vs. 18.7, months, P= 0.004).

Conclusion:
In the Japanese cohort, TSH was confirmed to be a safety procedure with an acceptable survival outcome. More than 10 liver nodules may be a predictor for unfavorable outcomes of patients with CRLM undergoing TSH. Furthermore, repeat hepatectomy can be a salvage treatment for resectable intrahepatic recurrence after TSH.