bluuebunny/crossref_metadata_2025_split huggingface dataset:
Aquatic macroinvertebrate community and water quality in River Tambo, Arequipa region, Peru
Authors: Coayla-Peñaloza Pastor , Cheneaux-Diaz André Alexander , Moreno.Salazar Claudia Viviana , Cruz-Remache Cynthia Elizabeth , Damborenea Cristina 
Published: May 2024

Introduction: The River Tambo basin is one of the main hydrographic systems of the Peruvian western watershed, being a source of development for agriculture, agroindustry, livestock, and domestic use in the Tambo Valley and Arequipa City. Objective: To analyze the structure of macroinvertebrates in River Tambo, Perú and assess the water quality through this community. Methods: Five sampling events were conducted between December 2018 and November 2019 in 12 stations, using a Surber net (500 μm). Macroinvertebrates were identified at a family level. To assess community structure, richness, Simpson’s dominance index (D), Pielou’s evenness (J’), and true diversity of order 1 were determined. A nMDS based on the Bray-Curtis index was used to evaluate dissimilarity. To check for differences in community structure, ANOSIM and two-way MANOVA were used. SIMPER was used to establish family contribution to sample similarity. Relations between physicochemical and biological variables were determined by CCA. ABI index was applied to assess ecological quality. Results: 32 families were recognized, being the most abundant: Baetidae, Chironomidae, Leptohyphidae, Simuliidae, Hydroptilidae, and Elmidae. The middle and low zones of the basin showed the highest and lowest diversity respectively. There were significant differences (P < 0.05) in the community structure indices among the 12 stations differed. There was a higher similarity among the 12 stations in December. ABI scores increased from the low to the middle part of the river, which showed the highest ecological quality. Conclusion: Macroinvertebrate communities from River Tambo reflect ecosystem conditions. Environments impacted by human activities show lower diversity and ecological quality, due to the structure, habitat, and water quality of the river being altered.
Gender confusions and other linguistic changes
Authors: Szlovicsák Béla 
Published: May 2024

AbstractThe main goal of this paper is to provide a preliminary examination of the interaction between the Vulgar Latin grammatical gender system and other levels of linguistic change, such as phonological confusions. To achieve this description conditional inference trees and random forests were fitted to our data which enabled a more thorough understanding of these interactions than would be possible to notice without statistical methods.
Costo del control de Aedes aegypti en la Amazonía peruana
Authors: Durand Salomon , Paredes Arles , Pacheco Carlos , Fernandez Ray , Herrera Jose , Cabezas César 
Published: May 2024

Objectives. To estimate the costs incurred in the control of Aedes aegypti in the Loreto region, during the years 2017 and 2018. Materials and methods. We conducted a partial retrospective economic evaluation of the costs of Aedes aegypti control of the Regional Health Directorate Loreto, during the implementation of the Regional Plan for Surveillance and Control of Aedes aegypti. Documentation such as plans, intervention reports and payment slips were reviewed, and interviews were conducted with professional personnel involved in vector control, on the costs of control interventions. Results. We found that the costs incurred in dengue vectorcontrol in the Loreto Region in the two years were: PEN 3,807,858 and PEN 4,066,380 during 2017 and 2018, respectively (USD 1,175,264 and USD 1,1210,232 at the 2017 and 2018 exchange rate). However, the effect of control activities is short-lived. Conclusions. The high cost involved in vector control with the methods currently used and the short duration of its effect make it unsustainable. Studies should be conducted in order to find other more efficient methods for dengue control.
Factors associated with the consumption of medicinal plants for the prevention of COVID-19 in peruvian population: a cross-sectional study
Authors: Ccami-Bernal Fabricio , Rojas-Miliano Cristhian , Soriano-Moreno David R. , Fernández-Guzmán Daniel , Quispe-Vicuña Carlos , Hernández- Bustamante Enrique A. , Zamora-Huaringa Elvira G. , Nieto-Gutiérrez Wendy 
Published: May 2024

Objetivos. Determinar los factores asociados al consumo de plantas medicinales como prevención de la COVID-19 en la población peruana. Materiales y métodos. Se evaluó población mayor de 18 años, residentes en Perú y sin antecedentes de enfermedad por COVID-19. Los factores asociados al consumo de plantas medicinales se evaluaron mediante un modelo de regresión de Poisson con varianzas robustas. Resultados. De 3231 participantes incluidos, el 84,6% eran jóvenes (18-29 años), el 62,7% eran mujeres y el 59,7% consumía alguna planta medicinal para prevenir la COVID-19. Los factores asociados al consumo de plantas medicinales para prevenir el contagio de COVID-19 fueron residir en la sierra peruana, haber tenido un familiar diagnosticado con COVID-19, haber tenido un familiar fallecido por COVID-19, considerar que su familia se encuentra en mayor riesgo de infección, haber usado medicamentos o dióxido de cloro paraprevenir la COVID-19, tener información médica como principal fuente de información sobre la COVID-19, pensar que las plantas medicinales son efectivas para prevenir la enfermedad COVID-19 o no estar informado sobre su eficacia. Conclusión. El 60% de los participantes reportó haber consumido alguna planta medicinal para prevenir la COVID-19. Es importante que las autoridades apliquen estrategias de comunicación sobre lo que implica el consumo de plantas medicinales, priorizando los grupos poblacionales que tienen mayores patrones de consumo.
Lake Baikal amphipods and their genomes, great and small
Authors: Drozdova P. B. , Madyarova E. V. , Gurkov A. N. , Saranchina A. E. , Romanova E. V. , Petunina J. V. , Peretolchina T. E. , Sherbakov D. Y. , Timofeyev M. A. 
Published: May 2024

Endemic amphipods (Crustacea: Amphipoda) of Lake Baikal represent an outstanding example of large species flocks occupying a wide range of ecological niches and originating from a handful of ancestor species. Their development took place at a restricted territory and is thus open for comprehensive research. Such examples provide unique opportunities for studying behavioral, anatomic, or physiological adaptations in multiple combinations of environmental conditions and thus attract considerable attention. The existing taxonomies of this group list over 350 species and subspecies, which, according to the molecular phylogenetic studies of marker genes, full transcriptomes and mitochondrial genomes, originated from at least two introductions into the lake. The studies of allozymes and marker genes have revealed a significant cryptic diversity in Baikal amphipods, as well as a large variance in genetic diversity within some morphological species. Crossing experiments conducted so far for two morphological species suggest that the differences in the mitochondrial marker (cytochrome c oxidase subunit I gene) can potentially be applied for making predictions about reproductive isolation. For about one­tenth of the Baikal amphipod species, nuclear genome sizes and chromosome numbers are known. While genome sizes vary within one order of magnitude, the karyotypes are relatively stable (2n = 52 for most species studied). Moreover, analysis of the diversity of repeated sequences in nuclear genomes showed significant between­species differences. Studies of mitochondrial genomes revealed some unusual features, such as variation in length and gene order, as well as duplications of tRNA genes, some of which also underwent remolding (change in anticodon specificity due to point mutations). The next important steps should be (i) the assembly of whole genomes for different species of Baikal amphipods, which is at the moment hampered by complicated genome structures with high repeat content, and (ii) updating species taxonomy taking into account all the data.
Predicting positive surgical margins in patients treated with robot-assisted partial nephrectomy: results from a prospectively maintained dataset of a single tertiary referral center
Authors: Mari Andrea , Grosso Antonio Andrea , Coco Simone , Cadenar Anna , Bacchiani Mara , Lambertini Luca , Massaro Eleana , Cangemi Vincenzo , Cianchi Gemma , Sandulli Alessandro , Conte Francesco Lupo , Salamone Vincenzo , Mariottini Riccardo , Giudici Sofia , Maida Fabrizio Di , Olivera Laura , Oriti Rino , Scelzi Sabino , Vittori Gianni , Masieri Lorenzo , Minervini Andrea 
Published: May 2024

Aim: To identify the incidence and evaluate predictors of positive surgical margins (PSMs) after robot-assisted partial nephrectomy (RAPN) in patients with clinical T1 renal cell carcinoma (RCC).
Methods: After securing ethics committee approval, we analyzed our institution’s prospectively maintained RCC database. Our cohort included 1611 patients who underwent RAPN between January 2017 and December 2022. Surgical specimens were evaluated using standard practices, and the International Society of Urological Pathology (ISUP) grading system was employed.
Results: The majority (69.5%) of the 1,611 patients were males. Median age and Body Mass Index were 62.6 years and 26.9 kg/m2, respectively. Overall, 18.6% and 21.1% of the patients had an Eastern Cooperative Oncology Group (ECOG) score ≥ 1 and American Society of Anesthesiologists physical status (ASA PS) score ≥ 3, respectively. Surgical indications were elective in 90.5% of cases. The preoperative aspects and dimensions used for an anatomical (PADUA) score median was 8.0 (interquartile range: 7.0-9.5). The predominant histotype was clear cell RCC, accounting for 70.4% of the cohort. PSMs were detected in 6.7% of the patients. Multivariable logistic regression showed surgical indications with an odds ratio (OR) of 6.06 (P < 0.001), surface, intermediate, base (SIB) score > 1 with an OR of 2.37 (P = 0.001), and PADUA score with an OR of 1.10 (P = 0.006) were significant predictors of PSMs.
Conclusion: Attaining negative margins remains the oncological cornerstone of partial nephrectomy. Our data underscore that tumor-specific (PADUA score) and surgical parameters (imperative indication, SIB score > 1, off-clamp approach) are the principal determinants for PSMs after RAPN.
The Wagner Cone Stem for Atypical Femoral Anatomy in Total Hip Arthroplasty
Authors: Kayani Babar , Neufeld Michael E. , Bautista Maria , Howard Lisa C. , Abdelmalek Mohammed , Greidanus Nelson V. , Masri Bassam A. , Garbuz Donald S. 
Published: May 2024

Background:
The Wagner Cone Prosthesis was designed to address complex femoral deformities during total hip arthroplasty (THA), but its mid-term component survivorship and functional outcomes remain undetermined. The objectives of this study were to determine the implant survivorship, patient satisfaction, functional outcomes, osseointegration as seen radiographically, implant subsidence, and complications of THA using the Wagner Cone Prosthesis stem at intermediate-term follow-up.

Methods:
This study involved 302 patients with proximal femoral deformities, including developmental hip dysplasia and Legg-Calvé-Perthes disease, who underwent a total of 320 primary THAs using the Wagner Cone Prosthesis. The average age at the time of surgery was 49.4 ± 14.5 years (range, 18.8 to 85.6 years). Patient satisfaction was recorded using a self-administered questionnaire assessing satisfaction in 4 domains. The University of California at Los Angeles (UCLA) activity score, the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), the Oxford Hip Score (OHS), the Forgotten Joint Score (FJS), radiographic outcomes, and complications were recorded. The mean follow-up time was 10.1 years (range, 5.2 to 15.5 years).

Results:
Survivorship of the Wagner Cone Prosthesis was 98.7% (95% confidence interval [CI]: 97.2% to 100%) with stem revision as the end point and 95.8% (95% CI: 93.5% to 98.2%) with reoperation for any reason as the end point at 10 years postoperatively. In total, 3 stems were revised: 2 for infection and 1 for chronic hip dislocation. The median patient satisfaction score was 95 (interquartile range [IQR], 80 to 100), median UCLA score was 6 (IQR, 6 to 7), median WOMAC score was 18 (IQR, 16 to 22), median OHS was 40 (IQR, 36 to 47), and median FJS was 80 (IQR, 76 to 88) at the time of final follow-up. All Wagner Cone stems that were not revised showed radiographic evidence of osseointegration, with a mean stem subsidence of 0.9 ± 0.8 mm at the most recent follow-up.

Conclusions:
The use of the Wagner Cone Prosthesis stem in patients with complex femoral anatomy undergoing primary THA is associated with excellent component survivorship, high levels of patient satisfaction, good functional outcomes, and reliable osseointegration with minimal stem subsidence as seen on radiographs at intermediate-term follow-up.

Level of Evidence:
Therapeutic Level IV. See Instructions for Authors for a complete description of levels of evidence.
Effects of Reciting Qur'an (Ruqyah on Sleep Quality of Elderly People Living in A Nursing Home
Authors: . Mardiyanti , Yuanita Ita , Pratiwi Sherly Mulya 
Published: May 2024

Elderly are at risk of having poor sleep quality due to chronic illness, emotional distress, anxiety, environment, malnutrition and low physical activities. Evidence showed religious therapy effectively improve mental health, reduce anxiety and depression. However, the use of ruqyah syar’iyyah for managing sleep disturbance has not been studied well, therefore this research aimed to investigate the effectiveness of ruqyah therapy on sleep quality of elderly people. This study used Quasi Experimental with one group Pre-test Post-test design approach. Elderly in the nursing homes were selected based on their Pittsburgh Sleep Quality Index (PSQI) score. Seventeen elderly with PSQI> 5, Muslim and followed all the study program were participated in this study analysis. The intervention was done by reciting selected Surah in the Qur’an once a day for three nights. The post-test was held on the last day of data collection by measuring PSQI. The age of respondents range from 61-82 years old with the majority in the elderly age (60- to 74-year-old with 76,5%), most of the education level of the respondents were elementary school (64,7%). The PSQI mean score was 14,88 ± 2,09 (pre-test) vs 9.12 ± 1,6 (post-test) P-value<0.05. Ruqyah syar’iyyah improves the elderly quality of sleep by significantly reduces the PSQI score. Ruqyah therapy may help elderly managing psychological issues that interfere their sleep latency and sleep duration. However, the study does not differentiate the group base on the cause of poor sleep quality. Therefore, it is suggested to study the effect of ruqyah therapy based on the cause of poor sleep quality of the elderly. Nurses and other heathcare providers are suggested to use Ruqyah therapy for intervening poor sleep quality among elderly
WITHDRAWN: Implementation of Reliability Centered Maintenance (RCM) in the background of industry 4.0 –Issues, Challenges, and Opportunities
Authors: Ur Rahman Khalil , Mian Zhibao , Yasir Ali 
Published: May 2024

Abstract

The full text of this preprint has been withdrawn, as it was submitted in error. Therefore, the authors do not wish this work to be cited as a reference. Questions should be directed to the corresponding author.
Associations between serum 25-hydroxyvitamin D and prognosis of chronic kidney disease: a prospective cohort study
Authors: Mai Yanpei , Yi Yushan , Wen Yaqing , Huang Peixian , Wang Yuying , Wang Zhirui 
Published: May 2024

Abstract

Background and objectives: 25-hydroxyvitamin D [25(OH)D] deficiency is prevalent in patients with chronic kidney disease (CKD), the associations between serum 25(OH)D levels and mortality in patients with CKD remain unclear, and this study aimed to explore these associations further.
Methods: 4989 participants with CKD were enrolled in the study, and the Cox regression model was used to assess the effects of serum 25(OH)D concentrations on mortality risk. A restricted cubic spline model was used to explore the dose-response relationships, and threshold effect analysis was performed based on inflection points identified by a two-piecewise linear regression model. In addition, subgroup and sensitivity analyses were employed.
Results: 1255 participants died during a mean follow-up period of 70 months. Compared with the 25(OH)D-deficient group, the fully adjusted hazard ratios and 95% confidence intervals for the 25(OH)D-adequate group were 0.631 (0.545, 0.730) for all-cause mortality, 0.569 (0.435, 0.743) for cardiovascular mortality, 0.637 (0.461, 0.878) for hypertension mortality, and cancer mortality was 0.596 (0.426, 0.834). The inflection points of serum 25(OH)D concentration affecting all-cause and cardiovascular mortality were 89 nmol/L, and 107 nmol/L, respectively. Subgroup analyses and interaction tests suggested that the effects varied across populations. The results of sensitivity analyses indicated a reliable correlation.
Conclusion: We found an association between serum 25(OH)D concentrations and the prognosis of patients with CKD as a reliable predictor of early intervention and intensive care.
Feasibility and Preliminary Efficacy of The Ankle Bracelet Laser: A new portable device to improve walking in Parkinsonism patients, Randomized Cross-Over Control Pilot Trial
Authors: Ratanasutiranont Chompoonuch , Srisi Kwan , Ruthiraphong Peeraya 
Published: May 2024

Abstract

Background:
Freezing of gait (FOG) is a common and debilitating symptom of parkinsonism. Although visual cues have proven efficacy in alleviating FOG, current visual cues are fixed, and mobile open-loop system may be too difficult to use in some patients, leading to equivocal results in improving gait performance.
Objective:
To assess the efficacy of an ankle bracelet laser, a new mobile visual cue with practical use, in improving gait performance in parkinsonism patients with FOG.
Methods
A randomized controlled two-period crossover trial was conducted from June 15th, 2020 to October 1st, 2020 at Ramathibodi Hospital. Ten parkinsonism patients with FOG were enrolled in two conditions: walking with laser-off first and walking with laser-on first. Gait speed, the Timed Up and Go (TUG) test, stride length, and the locomotor rehabilitation index (LRI) were assessed twice in each trial with a 10-minute washout period.
Results
The results showed favorable results of improvement in all parameters. Gait speed and stride length improved by 0.07 m/s (95% confidence interval [CI]: 0.04–0.09; P < 0.001) and 0.17 m (95% CI: 0.11–0.23; P < 0.001), respectively, with laser-on. The TUG test duration was reduced by 7.69 s (95% CI: 2.82–12.55; P = 0.002). The locomotor rehabilitation index (LRI) improved by 4.46% (95% CI: 2.56–6.36; P < 0.001). When using the device, there were no adverse effects, such as dizziness or blurred vision.
Conclusions
The ankle bracelet laser improved walking performance in parkinsonism patients with FOG immediately and might have the potential to provide cueing during daily life.
Comparative Overdose Mortality, Morbidity and Abuse of Common Prescription Opioids
Authors: Channell Jessie , Schug Stephan 
Published: May 2024

Abstract

Objective: assess the overdose mortality of buprenorphine, fentanyl, hydromorphone, morphine, oxycodone, tapentadol and tramadol in Australia and the morbidity and abuse rates in Western Australia.
Design: Retrospective observational study.
Setting: Australian and/or Western Australian data from the following sources; National Coronial Information System (NCIS), Western Australian Poisons Information Centre (WAPIC), Western Australian Mental Health Commission (WAMHC).
Main outcome measures: Overdose mortality (deaths attributed to opioid toxicity by the coroner), morbidity (calls to WAPIC regarding moderate to severe opioid toxicity) and abuse (number of new opioid abuse WAMHC cases and calls to WAPIC where the opioid toxicity was related to abuse) of prescription opioids, per 100,000 grams oral morphine equivalent dispensed.
Results: The overall risk of overdose mortality per prescription opioid dispensed increased by 7% over the study period. The risk of mortality, with morphine as the reference opioid, in order from highest to lowest mortality is; oxycodone 69% lower; tramadol 78%; fentanyl 84%; buprenorphine 87%; hydromorphone 91%; and tapentadol at 96% lower. Analysis of morbidity data found a significant 17% decline in the rate of cases detected for buprenorphine and a significant 11% increase in cases for oxycodone. Abuse data was insufficient to achieve statistical significance.
Conclusions: The rates of overdose mortality, morbidity and abuse differ according to the opioid dispensed even once availability and opioid strength is accounted for. These differences may be due to the inherent difference in the pharmacokinetics of each opioid and their unique effect upon the individual.
Autologous atrial appendage micrografts transplanted during coronary artery bypass surgery: design of the AAMS2 randomized, double-blinded, and placebo-controlled trial
Authors: Sikorski Vilbert Touho Jan , Nummi Annu , Kuuva Aleksi , Wilkman Erika , Rajala Helena , Stewart Juhani , Junttila Juhani , Lindgren Kai , Kervinen Kari , Teittinen Kari , Kohonen Katja , Oksaharju Kati , Okkonen Marjo , Holmström Miia , Lehtinen Miia , Mulari Severi , Taskinen Panu , Karvonen Päivi , Kastell Päivi , Kärjä-Koskenkari Päivi , Kandolin Riina , Kesävuori Risto , Kaarlenkaski Sari , Dahlbacka Sebastian , Syrjälä Simo , Syväranta Suvi , Juvonen Tatu , Erkinaro Tiina , Mäkelä Tuomas , Karjalainen Pasi , Kankuri Esko , Vento Antti , Nykänen Antti 
Published: May 2024

Abstract

Background—The AAMS open-label clinical study demonstrated safety and feasibility of epicardial transplantation of autologous right atrial appendage micrografts (AAMs) during coronary artery bypass grafting (CABG) surgery. Delivered in an extracellular matrix patch, the study also provided first indications of reduced ischemic scar and increased live ventricular wall thickness associated with AAMs therapy. To further evaluate the initial beneficial effects observed in the AAMS study, we designed the randomized, double-blinded, and placebo-controlled AAMS2 trial. Focusing on patients with ischemic heart failure with reduced ejection fraction (iHFrEF), the AAMS2 trial aims to generate state-of-the-art structural and functional imaging data on the myocardium treated with an AAMs-patch during CABG.
Methods—The AAMS2 trial recruits iHFrEF patients who are set to undergo non-urgent CABG and present with a myocardial scar in preoperative cardiac magnetic resonance (CMR) with late gadolinium enhancement. Patients are randomized evenly (1:1) to receive an collagen-based matrix patch (Hemopatch®), with or without AAMs, epicardially onto the scar border. The primary endpoints at 6 months post-operatively are the effect change on the myocardial scar size by the AAMs-patch transplantation site, as assessed by CMR with late gadolinium enhancement and change in blood N-terminal-pro-BNP in the timeframe. The trial’s secondary endpoints address feasibility, safety, echocardiography, quality of life, symptom scaling, and 6-minute walk test.
Discussion—Data from the AAMS2 trial provide the first randomized, blinded, and placebo-controlled evaluation of efficacy on epicardial AAMs transplantation for iHFrEF. This data then enables the rational design of larger AAMs therapeutic efficacy-addressing trial(s).
Trial Registration: ClinicalTrials.gov, NCT05632432, registered 30 November 2022, https://clinicaltrials.gov/study/NCT05632432