bluuebunny/crossref_metadata_2025_split huggingface dataset:
Influence of Thread Design on Implant Positioning in Immediate Implant Placement
Authors: Koticha Tapan , Fu Jia‐Hui , Chan Hsun‐Liang , Wang Hom‐Lay 
Published: February 2012

Background: It is generally believed that implants placed in extraction sockets have a tendency to shift in the facial direction during insertion. The purpose of this study is to investigate the effect of different thread designs on the final implant position in immediate implant placement.Methods: In a split‐mouth design involving 11 cadaver heads, each specimen received two implants, one with a square and one with a V‐shaped thread design, in maxillary incisor extraction sockets. The facio‐lingual locations of the drills and the implant were tracked, and the displacements were compared between the two groups.Results: No statistically significant differences were observed between the square and V‐shaped thread design groups. The mean displacements of the different groups showed a general tendency of the implants to be positioned facially compared with the initial drill trajectory. This tendency was greater for implants with square thread design.Conclusion: There was no significant effect of implant thread design on the positioning of implants in extraction sockets.
Surveillance of bacterial contamination in small animal veterinary hospitals with special focus on antimicrobial resistance and virulence traits of enterococci
Authors: KuKanich Kate S. , Ghosh Anuradha , Skarbek Jennifer V. , Lothamer; Ludek Zurek Kale M. 
Published: February 2012

Abstract
Objective—To determine the prevalence of bacterial contamination on 4 surfaces of 4 types of standard equipment in small animal veterinary hospitals.
Design—Surveillance study.
Sample—10 small animal veterinary hospitals.
Procedures—Each hospital was visited 3 times at 4-month intervals; at each visit, a cage door, stethoscope, rectal thermometer, and mouth gag were swabbed. Swab samples were each plated onto media for culture of enterococci and organisms in the family Enterobacteriaceae. Enterococci were identified via a species-specific PCR assay and sodA gene sequencing; species of Enterobacteriaceae were identified with a biochemical test kit. Antimicrobial susceptibility was assessed via the disk diffusion method. Enterococci were screened for virulence traits and genotyped to assess clonality.
Results—Among the 10 hospitals, enterococci were isolated from cage doors in 7, from stethoscopes in 7, from thermometers in 6, and from mouth gags in 1; contamination with species of Enterobacteriaceae was rare. Enterococci were mainly represented by Enterococcus faecium (35.4%), Enterococcus faecalis (33.2%), and Enterococcus hirae (28.3%). Antimicrobial resistance was common in E faecium, whereas virulence traits were present in 99% of E faecalis isolates but not in E faecium isolates. Clonal multidrug-resistant E faecium was isolated from several surfaces at 1 hospital over multiple visits, whereas sporadic nonclonal contamination was detected in other hospitals.
Conclusions and Clinical Relevance—Contamination of surfaces in small animal veterinary hospitals with multidrug-resistant enterococci is a potential concern for pets and humans contacting these surfaces. Implementing precautions to minimize enterococcal contamination on these surfaces is recommended.
Immediate Results of Percutaneous Trans-Luminal Mitral Commissurotomy in Pregnant Women with Severe Mitral Stenosis
Authors: Abdi Seyfollah , Salehi Negar , Ghodsi Babak , Basiri Hossein Ali , Momtahen Mahmoud , Firouzi Ata , Sanati Hamid Reza , Shakerian Farshad , Maadani Mohsen , Bakhshandeh Homan , Chamanian Soheila , Chitsazan Mitra , Vakili-Zarch Anoushiravan 
Published: February 2012

Background Valvular heart diseases and mainly rheumatic heart diseases complicate about 1% of pregnancies. During pregnancy physiological hemodynamic changes of the circulation are the main cause of mitral stenosis (MS) decompensation. Prior to introduction of percutaneous mitral balloon commissuroplasty (PTMC), surgical comissurotomy was the preferred method of treatment in patients with refractory symptoms. PTMC is an established non-surgical treatment of rheumatic mitral stenosis. The study aimed to assess the safety and efficacy of PTMC in pregnant women with severs mitral stenosis. Material and Method Thirty three consecutive patients undergoing PTMC during pregnancy enrolled in this prospective study. Mitral valve area (MVA), transmitral valve gradient (MVG), and severity of mitral regurgitation (MR) were assessed before and 24 hour after the procedure by transthoracic and transesophageal echocardiography. Mitral valve morphology was evaluated before the procedure using Wilkin's criteria. Patient followed for one month and neonates monitored for weight and height and adverse effect of radiation. Result Mitral valve area increased from 0.83 ± 0.13 cm2 to 1.38 ± 0.29 cm2 ( P = 0.007). Mean gradient of mitral valve decreased from 15.5 ± 7.4 mmHg to 2.3 ± 2.3 mmHg ( P = <0.001). Pulmonary artery pressure decreased from 65.24 ± 17.9 to 50.45 ± 15.33 ( P = 0.012). No maternal death, abortion, intrauterine growth restriction was observed and only one stillbirth occurred. Conclusion PTMC in pregnant women has favorable outcome and no harmful effect on children noted.
Malignant Ovarian Tumors with Induced Expression of Carbonyl Reductase Show Spontaneous Regression
Authors: Wang Hui , Yokoyama Yoshihito , Tsuchida Shigeki , Mizunuma Hideki 
Published: February 2012

Background The present study investigated tumor proliferation in a tumor model using murine ovarian cancer cells with increased carbonyl reductase (CR) expression. Methods CR cDNA was transfected into murine T-Ag-MOSE ovarian cancer cells by lipofection. CR-transfected cells (CR induction group) or empty vector-treated cells (control group) were injected into the backs of 8-week-old nude mice at a concentration of 0.5 × 10 6 per 0.2 mL. Subsequent tumor proliferation in both groups was observed for 5 weeks. Results The control group showed an increase in tumor volume during the 5 weeks of observation. However, tumor volume in the CR induction group increased up to the second week but then decreased continuously until the fifth week of observation. The tumor growth curves for the two groups showed a significant difference (Mann-Whitney U test, P < 0.001). Histological and biochemical experiments were performed using tumor tissues isolated in the third week. Necrosis and inflammatory cell infiltration were noted for tumors in the CR induction group. Also, the number of apoptotic cells was significantly increased in the CR induction group compared with the control group ( P < 0.001). Milk fat globule EGF factor 8, an “eat-me” signal for phagocytes such as macrophages, was expressed extensively in the tumor cytoplasm and interstitial cells of the CR induction group, and engulfment of apoptotic cells by macrophages was observed. Vascular endothelial growth factor expression in tumors was notably decreased in the CR induction group compared with the control group. Conclusion Increased necrosis due to engulfing of apoptotic cells by phagocytes attracted by increased milk fat globule EGF factor 8 was considered to be the mechanism of spontaneous tumor regression in the CR induction group.
Toxic anterior segment syndrome outbreak after vitrectomy and silicone oil injection
Authors: Moisseiev Elad , Barak Adiel 
Published: February 2012

Purpose To report a rare outbreak of toxic anterior segment syndrome (TASS) in 4 patients who underwent vitrectomy with silicone oil injection. Methods Review of the medical charts of all patients who underwent surgery in the operating theater of our department during a 10-day period in May 2011. Results We report on 4 patients who developed TASS after vitrectomy with silicone oil injection. The clinical presentation was typical of TASS, and different from the anterior chamber reaction that may occur after silicone oil injection. All cases were treated effectively with topical steroids, and the outbreak stopped after the silicone oil batch was exchanged. Conclusions We discuss the possible mechanisms for this unusual TASS outbreak, and suggest the silicone oil as its cause.
Perceived Taste Loss From Early Adulthood to Mid to Late Adulthood and Mortality
Authors: Zhu Ruixin , Wang Ran , He Jingjing , Zhang Liwei , An Peng , Li Keji , Ren Fazheng , Xu Weili , Guo Jie 
Published: February 2025

ImportanceEvidence on the associations of taste function changes from early adulthood to mid to late adulthood with all-cause mortality is limited.ObjectiveTo investigate the associations between subjective perception of taste loss from early adulthood to mid to late adulthood and all-cause mortality.Design, Setting, and ParticipantsThis population-based cohort study used data from the US National Health and Nutrition Examination Survey (2011-2014) and linked mortality information from the National Death Index (NDI) and included adults aged 40 years and older. Data analyses were conducted between May 6, 2024, and July 22, 2024.ExposuresSubjective decline in taste function and ability to detect basic tastes (ie, salt, sourness, sweetness, or bitterness) since the age of 25 years.Main Outcomes and MeasuresAll-cause mortality was ascertained via linkage to the NDI with follow-up until December 31, 2019.ResultsAmong 7340 participants (52.8% female), 662 (weighted, 8.9%) reported subjective perception of taste loss from early adulthood to mid to late adulthood. During a median (IQR) follow-up of 6.67 (5.67-7.83) years, 1011 deaths occurred. Subjective perception of taste loss was associated with a 47% higher risk of mortality (multiadjusted hazard ratio [HR], 1.47; 95% CI, 1.06-2.03). Specifically, self-reported loss in ability to taste salt (multivariable adjusted HR [aHR], 1.65; 95% CI, 1.21-2.26) and sourness (aHR, 1.69; 95% CI, 1.19-2.40) was associated with increased mortality. Self-reported decline in ability to taste bitterness was associated with increased mortality only in female participants (aHR, 1.63; 95% CI, 1.05-2.53), whereas decline in ability to taste sourness was associated with increased mortality only in male participants (aHR, 1.69; 95% CI, 1.03-2.75). Moreover, among all and female participants without perceived smell function loss, those with perceived taste function loss still had increased mortality (all participants: aHR, 1.64; 95% CI, 1.12-2.40; female participants: aHR, 1.71; 95% CI, 1.14-2.56; male participants: aHR, 1.44; 95% CI, 0.80-2.59).Conclusions and RelevanceIn this population-based cohort study, subjective perception of taste loss from early adulthood to mid to late adulthood, particularly perception of salt and sourness, was associated with increased all-cause mortality. The mortality risk associated with perceived taste loss could not be mitigated by undeteriorated smell function. These findings suggest that subjective perception of taste loss may serve as a simple and valuable indicator for screening high-risk populations in clinic and public health practice.
Atomic Layer Deposition of ZnO Coating on Biodegradable Fe‐Based Alloys
Authors: Paul Birgit , Bahrami Amin , Hahn Veronika , Quade Antje , Datye Amit , Kosiba Konrad , Pilz Stefan , Goldberg Phil , Schwarz Udo D. , Hempel Frank , Hufenbach Julia , Nielsch Kornelius 
Published: February 2025

AbstractAs implant‐related infections increase with a simultaneously increasing demand for implants, new material design concepts are needed to prevent such occasions from leading to failure or mortality. One approach is the antibacterial coating of implant materials with ZnO. This study applies ZnO by atomic layer deposition (ALD) on the novel class of temporary metallic implant materials. The biodegradable alloy Fe69Mn30C1 is applied as substrate. Three different coating thicknesses (33, 45, and 60 nm) deposited at the very low temperature of 100 °C are investigated regarding their mechanical behavior, roughness, wettability and in vitro degradation. With increasing thickness of the ALD coating, the roughness and corresponding contact angle slightly increased, although the surface remained hydrophilic. Initial corrosion products are analyzed by X‐ray photoelectron spectroscopy, where Zn with Phosphorous‐Oxygen compounds are identified. Furthermore, the antibacterial effect of a ZnO coating is tested against Gram‐positive Staphylococcus aureus compared to uncoated Fe69Mn30C1 and clinically applied 316L stainless steel. The ZnO coating clearly enhanced the antibacterial effect in direct material contact with S. aureus, inhibitory rate of up to 99.2% compared to uncoated 316L. As an outlook for further studies, it is demonstrated that an additively manufactured generic 3D structure can be coated using ALD.
Plasmon Induced Charge Transfer Dynamics in Metallic Nanoparticle‐MoSe2 Nanoflake Heterostructures
Authors: Verma P. K. , Kumar Vignesh Balaji , Srinivasan Varadharajan 
Published: February 2025

AbstractPlasmon‐induced hot carrier dynamics are crucial in various practical applications such as water splitting and photovoltaics. A hybrid system formed by interfacing plasmonic Au or Ag metal nanoparticles with triangular MoSe2 nanoflakes is proposed, which also possess edge‐localized plasmons. Using time‐dependent density functional theory‐based simulations, this bi‐plasmonic system is shown to exhibit interfacial charge transfer induced by plasmonic excitations of either component. Tracking the fate of photoinduced plasmons in the system reveals that a significant pathway to their decay involves the direct transfer of hot‐carriers across the interface. This study finds that while the likelihoods of both the direct hot‐electron and hot‐hole transfers are comparable, in most cases considered, the latter dominates. The extent and net direction of direct charge transfer are found to depend on various tunable features of the interface, including the plasmon mode (nanoparticle or nanoflake) excited and the polarization of the light used. It is anticipated that this platform could prove extremely useful for widening the substrate scope in photocatalysis and photodetection applications.
Amorphous Ga2O3 Based Erasable Two‐Terminal Artificial Photonic Synapses
Authors: Gao Feng , Wang Tianyi , Bai Jinlong , Gong Weiqiang , Jiang Yan , Zhang Xitian , Li Lin 
Published: February 2025

AbstractPhotonic synapses have garnered significant attention in visual sensing due to their ability to sense and store optical information in high parallel. Compared to three‐terminal devices, two‐terminal photonic synapses offer a simpler structure and are easier to integrate with silicon readout integrated circuits. However, achieving an efficient erasure function in two‐terminal photonic synapses has posed a formidable challenge, thereby limiting their broader application. Here, a two‐terminal bend‐erasing photonic synaptic device is designed and fabricated based on amorphous Ga2O3 (a‐Ga2O3) films by regulating oxygen vacancies (ranging from 25.6–44.4%). As a result, a‐Ga2O3 photonic synapses optimized by vacancy control engineering demonstrate ultra‐high storage bit‐widths exceeding 5 bits and fundamental synaptic functions. In addition, a 5 × 5 photonic synapse array is constructed. After ten consecutive UV pulse stimulations, the pattern retains a memory level of 30.7% after 120 s of attenuation, reflecting the excellent storage performance. These synaptic functions are also observed in the flexible a‐Ga2O3 device, and data erasure is realized by straightforward mechanical bending of the device. This study provides a low‐cost method to fabricate erasable two‐terminal photonic synapses, which will promote the development of UV artificial retinas and bionic eyes, paving the way for future innovations in optoelectronic applications and neuromorphic systems.
A Feedback Loop Driven by H4K12 Lactylation and HDAC3 in Macrophages Regulates Lactate‐Induced Collagen Synthesis in Fibroblasts Via the TGF‐β Signaling
Authors: Zou Ying , Cao Mibu , Tai Meiling , Zhou Haoxian , Tao Li , Wu Shu , Yang Kaiye , Zhang Youliang , Ge Yuanlong , Wang Hao , Luo Shengkang , Ju Zhenyu 
Published: February 2025

AbstractThe decrease in fibroblast collagen is a primary contributor to skin aging. Lactate can participate in collagen synthesis through lysine lactylation by regulating gene transcription. However, the precise mechanism by which lactate influences collagen synthesis requires further investigation. This study demonstrates that the depletion of macrophages mitigates the stimulating effect of lactate on collagen synthesis in fibroblasts. Through joint CUT&Tag and RNA‐sequencing analyses, a feedback loop between H4K12 lactylation (H4K12la) and histone deacetylase 3 (HDAC3) in macrophages that drives lactate‐induced collagen synthesis are identified. Macrophages can uptake extracellular lactate via monocarboxylate transporter‐1 (MCT1), leading to an up‐regulation of H4K12la levels through a KAT5‐KAT8‐dependent mechanism in response to Poly‐L‐Lactic Acid (PLLA) stimulation, a source of low concentration and persistent lactate, thereby promoting collagen synthesis in fibroblasts. Furthermore, H4K12la is enriched at the promoters of TGF‐β1 and TGF‐β3, enhancing their transcription. Hyperlactylation of H4K12la inhibits the expression of the eraser HDAC3, while the activation of HDAC3 reduces H4K12la in macrophages and suppresses collagen synthesis in fibroblasts. In conclusion, this study illustrates that macrophages play a critical role in lactate‐induced collagen synthesis in the skin, and targeting the lactate‐H4K12la‐HDAC3‐TGF‐β axis may represent a novel approach for enhancing collagen production to combat skin aging.
Nanocatalysts in Biodiesel Production: Advancements, Challenges, and Sustainable Solutions
Authors: Damian Christopher Selvam , Devarajan Yuvarajan , J Ravikumar , T Raja 
Published: February 2025

AbstractThe application of nanocatalysts for the conversion of crude oil into biodiesel represents a promising strategy to mitigate environmental issues and diminish dependence on fossil fuels. This review scrutinizes contemporary developments in nanocatalyst technology pertaining to biodiesel synthesis, emphasizing the effectiveness, specificity, and ecological sustainability of various nanocatalysts, which include metal oxides, magnetic solid catalysts, and an array of other nanostructured materials. These catalysts have exhibited substantial potential in augmenting the efficiency and selectivity of biodiesel production, attributable to their enhanced catalytic performance, extensive surface area, and resilience to saponification, rendering them appropriate for diverse feedstocks such as recycled oils, animal fats, and plant oils. Notwithstanding the obstacles associated with production costs and recycling procedures, recent progress in economically viable manufacturing techniques and sustainable recovery methods, including magnetic separation approaches, offers significant promise. A thorough lifecycle assessment (LCA) remains imperative to appraise the environmental and economic viability of employing nanocatalysts, taking into account parameters, such as raw material acquisition, energy utilization, and waste generation. The review accentuates the superior efficacy of nanocatalysts in comparison to traditional heterogeneous catalysts, underscoring their capacity to expedite biodiesel synthesis and facilitate a transition toward a more environmentally sustainable energy paradigm.
Correlation Between Triglyceride‐Glucose Index and Microvascular Complications in Patients With Early‐ Onset of Type 2 Diabetes Mellitus
Authors: Ran Liu , Han Yang , Zhaohu Hao , Hailin Shao 
Published: February 2025

ABSTRACTObjectiveThis study aimed to explore the potential correlation between the triglyceride‐glucose (TyG) index and diabetic nephropathy (DN) and diabetic retinopathy (DR) in patients with early‐onset type 2 diabetes mellitus (T2DM).DesignThis cross‐sectional study statistically analysed TyG index levels across DN and DR stages in patients with early‐onset and non‐early‐onset T2DM.PatientsA total of 1530 T2DM patients were enrolled between January 2017 and August 2023 at Tianjin Fourth Central Hospital in Tianjin.MeasurementsCorrelation analysis and logistic regression were used to examine the association between the TyG index and microvascular complications. Kaplan–Meier plots and Cox regression analyses were employed to evaluate the effects of the TyG index on DN incidence. TyG index's diagnostic ability for DN was explored using the area under the receiver operating characteristic curve.ResultsIn patients with early‐onset T2DM, the TyG index gradually decreased with DR aggravation and gradually increased with DN aggravation, showing a negative correlation with DR and a positive correlation with DN in patients with early‐onset T2DM; logistic regression analysis suggested that the TyG index was an independent risk factor for DN (OR = 1.623, 95% CI = 1.175–2.242). The Cox regression analysis and Kaplan–Meier plots suggested that higher TyG was associated with an earlier incidence of DN in patients with early‐onset T2DM.ConclusionIn patients with early‐onset T2DM, the TyG index could be used to evaluate the risk of microvascular complications, with elevated TyG levels potentially indicating high risk of insulin– resistance related renal injury.
Achieving Sustainable Development Goals Through the Governance of Local Food Systems in Western Countries: A Realist Synthesis
Authors: Guillaumie Laurence , Kamgang Samuel Éric , Brotherton Marie‐Christine , Boiral Olivier 
Published: February 2025

ABSTRACTOver the last decade, various studies have focused on the functioning of local food policy councils and their key role in institutionalizing participatory governance mechanisms involving stakeholders concerned with the promotion of sustainable food systems. Nevertheless, the literature remains scattered, inconclusive, and mostly dissociated from the sustainable development goals (SDGs), which are increasingly used by organizations and government agencies alike. Based on a systematic analysis of 99 academic articles, this realist synthesis sheds light on sustainability outcomes and key success factors of local food system governance. Findings show that local food systems can play a significant role in achieving sustainability, although the coverage of the SDGs remains very uneven across the objectives considered. The study also shows the key role of several collaborative governance principles—including broad participation, facilitative leadership, and consensus‐building—in the success of these systems. Contributions to the literature and managerial implications are discussed.