bluuebunny/crossref_metadata_2025_split huggingface dataset:
AS TECNOLOGIAS DIGITAIS NO CONTEXTO ESCOLAR: RISCOS, REGRAS, NORMAS, CIDADANIA NA UTILIZAÇÃO
Authors: Ramos Dayana Passos , Mendes Aldemiro Dantas , Guarizzo Alexandro Biazi , Rodrigues Cícero Alexandro Diniz , Silva Éverton Marques da , Costa Francisco de Sousa , Augusto Neto José , Santos Leandro dos , Martins Olavo Falcão 
Published: May 2024

Este trabalho vem mostrar o quanto as tecnologias digitais são relevantes em sala de aula para o processo de aprendizagem, enfatizando ainda os riscos que as mesmas oferecem devido utilização sem fins educacionais e uso exagerado. Com isso, foi feito um estudo com o tema: Tecnologia, cidadania e educação: prática digitais e riscos no contexto das instituições escolares, e como problema: Por que o uso de tecnologias digitais nas escolas sem a devida segurança necessárias e finalidades podem prejudicar os usuários? Com objetivo geral: Analisar até que ponto as tecnologias digitais podem apresentar ameaças ao ensino formal nas escolas. Com os seguintes objetivos específicos: investigar o que pode ocorrer numa instituição escolar com emprego inadequado das tecnologias digitais; debater sobre os riscos que as tecnologias digitais podem ocasionar nas escolas e discutir medidas para reduzir, anular os problemas com uso de tecnologias digitais nos colégios. Tendo como justificativa e grande relevância, partindo do princípio no qual o uso de tecnologias é fator de debate e necessidade mundial para diversos ramos de negócio a utilização das tecnologias digitais tornando necessário, investigar quais desvantagens ela acarreta devido ao não comprimento de regras estabelecidas. A metodologia da pesquisa foi a bibliográfica, com revisão, leitura, análise com o objetivo de executar os escritos e estruturar de acordo com o estabelecido, esclarecendo os dados pertinentes. Com isso, ficou evidente, o quanto a educação, conscientização se faz necessário para o uso das tecnologias digitais para então ter-se respeito e equilíbrio no uso.
Resultater fra rapportering til Bivirkningsgruppen 2023
Authors: Björkman Lars 
Published: May 2024

English summary
Nor Tannlegeforen Tid. 2024; 134: 418-24.
This case study describes the oral rehabilitation of a patient with severe wear on teeth and restorations. A successful rehabilitation was achieved with emphasis on an even and axial force distribution throughout the dentition. Adjustable composites and temporary restorations were used to establish a favorable occlusal scheme before moving on to permanent restorations.
PATHOPHYSIOLOGICAL FEATURES OF GLIAL CELL CHANGES AND MARKERS OF BRAIN TISSUES DAMAGE IN TBI
Authors: Прохорычева Анна Алексеевна , Трашков Александр Петрович , Васильев Андрей Глебович 
Published: May 2024

Черепно-мозговая травма (ЧМТ) является основной причиной смертности и психических расстройств среди неврологической патологии. У многих пациентов ЧМТ оставляет долгосрочные последствия, которые могут быть связаны как с легкими нарушениями когнитивных функций, так и с тяжелой инвалидизацией. Известно, что механизмы повреждения при ЧМТ могут быть первичными, связанными с механическим воздействием на головной мозг, и вторичными, в основном вызванными астроцитами, микроглией и&nbsp; инфильтрированными иммунными клетками из периферических тканей, которые приводят к нейрональной и сосудистой дисфункции. Ввиду того, что эти механизмы, в частности вторичное повреждение, остаются не до конца изученными, существуют сложности, связанные с диагностикой и лечением ЧМТ. В поисках решения этой проблемы в последние десятилетия накопились существенные данные о количественной оценке биомаркеров ЧМТ, что может обеспечить клинически доступное окно для изучения механизмов, диагностики, мониторинга и прогнозирования исходов травмы головного мозга. Представлен краткий обзор посттравматических изменений в ткани головного мозга, связанных с ионными нарушениями, активацией астро- и микроглии, участием клеток иммунной системы, а также основных биомаркеров повреждения головного мозга, выделенных из крови и цереброспинальной жидкости.
Traumatic brain injury (TBI) is the leading cause of mortality and psychiatric disorders among neurologic pathology. In many patients, TBI leaves long-term sequelae that may involve both mild cognitive impairment and severe disability. It is known that the mechanisms of damage in traumatic brain injury can be primary, related to the mechanical impact on the brain, and secondary, mainly caused by astrocytes, microglia and infiltrated immune cells from peripheral tissues that lead to neuronal and vascular dysfunction. Because these mechanisms, particularly secondary injury, remain incompletely understood, there are difficulties associated with the diagnosis and treatment of TBI. In search of a solution to this problem, substantial data on the quantification of biomarkers of traumatic brain injury have accumulated in recent decades, which may provide a clinically accessible window to study the mechanisms, diagnosis, monitoring, and prediction of brain injury outcomes. The article is a brief review of posttraumatic changes in brain tissue associated with ionic disturbances, activation of astro- and microglia, involvement of immune system cells, and major biomarkers of brain injury isolated from blood and cerebrospinal fluid.
CHAPEROME: HISTORICAL PERSPECTIVE AND CURRENT CONCEPTS
Authors: Федоров Вячеслав Сергеевич , Ремизова Надежда Вячеславовна , Шевцов Максим Алексеевич 
Published: May 2024

Жизненный цикл клеток сопровождается постоянным синтезом, транспортом и деградацией полипептидных цепей — белков и сигнальных последовательностей. Каждая полипептидная цепь обладает четырьмя уровнями структуры, и принятие ею правильной пространственной конформации необходимо для экспрессии и функции молекулы. Препятствовать формированию правильной конформации могут гидрофобные взаимодействия или образование сульфидных мостиков. Более того, структуры высокого порядка белков нарушаются при различных стрессовых ответах на клетку. В ходе исследования процессов синтеза и агрегации белков были выявлены особые консервативные протеины, способные связываться с новосинтезированным или поврежденным полипептидом, придавая за счет последовательной связи с доменами узнавания функциональную структуру. Именно эти белки назвали молекулярными шаперонами. В их число входит суперсемейство белков теплового шока, синтез которых является неспецифичным ответом клетки на стресс. Для изучения процессов протеостаза необходимо понимание, что данные белки действуют лишь в тесной взаимосвязи с кошаперонами и другими вспомогательными молекулами. Такие совокупности называются шаперомом, или шаперонной машиной, и они представляют значительный интерес в биомедицинских исследованиях. В данном обзоре литературы представлены основные исторические этапы понимания шаперонов и шаперома как супрамолекулярного комплекса и их место в жизнедеятельности клетки.
The life cycle of cells is accompanied by constant synthesis, transport and degradation of polypeptide chains — proteins and signal sequences. Each polypeptide chain has four levels of structure, and its adoption of the correct spatial conformation is necessary for the expression of the function of the molecule. Hydrophobic interactions or the formation of sulfide bridges can prevent the formation of the correct conformation. Moreover, the high-order structures of proteins are disrupted by various stress responses to the cell. In the course of studying the processes of protein synthesis and aggregation, specific highly conserved proteins were identified that can bind to a newly synthesized or damaged polypeptide, imparting a functional structure due to the sequential connection with recognition domains. These proteins are called molecular chaperones. This includes the superfamily of heat shock proteins, the synthesis of which is a nonspecific cell response to stress. To study the processes of proteostasis, it is necessary to understand that these proteins act only in close relationship with cochaperones and other auxiliary molecules. Such aggregates are called chaperomes, or chaperone machineries, and are of considerable interest in biomedical research. This review discusses the historic perspective for chaperones and chaperome as a supramolecular complex as well as their place in cell proliferation.
ZMIZ1::ABL1 Fusion: An Uncommon Molecular Event With Clinical Implications in Pediatric Cancer
Authors: Booth Kevin T. A. , Schulte Rachael R. , Smith Laurin , Gao Hongyu , Stohler Ryan A. , Liu Yunlong , Reshmi Shalini C. , Vance Gail H. 
Published: May 2024

Context.—
Pediatric B-cell acute lymphoblastic leukemia is genetically and phenotypically heterogeneous, with a genetic landscape including chromosomal translocations that disrupt ABL proto-oncogene 1, non–receptor tyrosine kinase (ABL1).

Objective.—
To characterize an uncommon chromosomal translocation in acute leukemia.

Design.—
Genetic testing, including karyotype and fluorescence in situ hybridization (FISH) analysis, was used to determine the underlying genetic aberration driving the disorder and to guide disease classification and risk stratification. More-detailed testing using RNA sequencing was performed based on the results from these assays. Three-dimensional molecular modeling was used to visualize the impact of aberrant fused transcripts identified by transcriptome profiling.

Results.—
Karyotype analysis of the bone marrow demonstrated a complex karyotype with, most notably, a t(9;10)(q34.1;q22) translocation. ABL1 break-apart probe FISH findings supported ABL1 disruption. Bone marrow transcriptome analysis revealed mutant ZMIZ1::ABL1 (ZMIZ1, zinc finger MIZ-type containing 1) fusion transcripts as a consequence of t(9;10)(q34.1;q22). Three-dimensional modeling of the mutant ZMIZ1::ABL1 fusion protein confirmed an altered ABL1 protein structure compared to that of the wild type, suggesting a constitutively active conformation.

Conclusions.—
The t(9;10) translocation resulting in ZMIZ1::ABL1 fusion transcripts is an uncommon form of BCR::ABL1-like (BCR, BCR activator of RhoGEF and GTPase) acute lymphoblastic leukemia. Although the karyotype was complex, identifying the t(9;10)(q34.1;q22) translocation, ABL1 disruption, and ZMIZ1::ABL1 transcript enabled effective ABL1-targeted treatment. Our data support the use of tyrosine kinase inhibitors to treat ZMIZ1::ABL1-derived B-cell acute lymphoblastic leukemia.
Assistance in Preparing Simple Bookkeeping and MSME Taxation for the East Java Fatayat Business Group
Authors: Nugroho Wawan Cahyo , Yani Prawita , Susila Muktar Redy , Widiarto Hermono 
Published: May 2024

The Pawon Urip Program in Lumajang Regency is community empowerment in terms of food security and community nutrition with the aim of empowering the socio-economic sector of the Pejarakan Village community. Physical observations, social observations, and interviews, as well as exploratory descriptive analysis, were used to answer the research objectives. The economy of the people of Pejarakan Village is classified as lower middle class; this, of course, cannot be separated from the influence of less than optimal levels of education and land use; the social phenomenon of apathy is also reflected when people are too busy. Pawon Urip planting actually provides benefits to the community; although insignificant, all the processes that go through until the results can be enjoyed have an impact on the knowledge, psychological, and economic aspects of the community. The managerial implication in this research is that with assistance, MSME owners will better understand the basics of accounting and taxation, which will help them prepare their books correctly. Good bookkeeping will also help increase financial transparency and may impact investor or lender confidence. With accurate financial data, MSME management can make better business decisions. Whether in terms of investment, expenses, or other business strategies.
Assessing Tutors’ and Principals’ Perceptions on the Work Performance Appraisal System: A Case of Private Dar Es Salaam Teachers’ Colleges, Tanzania
Authors: Philip Eugen Mtemi , Mtulia Jabiri Bakari 
Published: May 2024

The study employed a qualitative approach using a case study design. The study was conducted at Dar es Salaam Region. Purposive and convenient sampling strategies were used to sample the respondents. The study involved a total of 49 respondents including 7 principals and 42 tutors. The data were collected through interview, focus group discussion, observation and documentary review. The major findings revealed that principals perceived the appraisal as potential since helped them to monitor tutors, conversely, tutors perceived the appraisal as useless since they are practiced in a bias basis. Also, many tutors indicated unawareness about strategies used to appraise them. It was further found that the principals and tutors have never attended any training concerning performance appraisal. From the findings, the study recommended that the government through the ministry of education has to formulate a specific policy to govern and enforce the colleges’ directors and principals on appropriate proceedings to appraise tutors’ work performance in private teachers’ colleges.
Utilitarian and Hedonic Shopping Motives and Attitude towards Online Shopping of Generation Z in Indonesia
Authors: Dewi Ike Janita , Mahemba Umbu Saga Ana Kaka 
Published: May 2024

The purpose of this study was to analyze the effect of hedonic and utilitarian shopping motives on generation Z's online repurchase intention. The study also aims at examining the interaction between consumers’ internal factor (that is, shopping motives) and external stimuli (i.e, product type) on online repurchase intention. This research uses a quantitative approach, namely explanatory research. The research was conducted on 143 respondents of generation Z in Indonesia. The data analysis technique used in this study is multiple regression with mediating variables and independent sample t-test. The results showed that: 1) Hedonic and utilitarian shopping motives positively affect online repurchase intention of generation Z, 2) Attitudes towards online shopping partially mediated the influenceof utlilitarian and hedonic shopping motives on online repurchase intention of generation Z, 3) Hedonic shopping motives’ influence on online repurchase intention of generation Z is higher than that of utilitarian motives if the product category is a hedonic product, and 4) Utilitarian shopping motives’ influence on online repurchase intention of generation Z is higher than that of hedonic motives if the product category is a utilitarian. The research provides important implications that consumers (especially Generation Z) have hedonic and utilitarian online shopping motives. Therefore, managers need to provide online shopping experience which can evoke both both hedonic and utilitarian shopping motives.
Radar Científico do IAMSPE – Instituto de Assistência Médica ao Servidor Público Estadual
Authors: Ribeiro Fabiano Rebouças 
Published: May 2024

Há muito tempo me incomodava o fato de não termos uma agenda científica no Iamspe e não sabermos o que acontece na nossa própria casa. Sem a agenda de eventos científicos, até parece que pouco se produz aqui ou pelo menos deixa esta impressão.
Com a criação do Radar Científico do Iamspe, parece que as luzes se acenderam e conseguimos enfim enxergar o que está bem na nossa frente: uma enxurrada de aulas nas diversas especialidades, treinamentos práticos no Cesir (Centro de Simulação Realística) de altíssima qualidade, defesas de mestrado e doutorado, cursos e até congressos, que acontecem bem aqui. Professores renomados ministrando aulas espetaculares dentro da instituição, quem sabe até mesmo na sala ao lado, sem que soubéssemos! Um verdadeiro absurdo!
Agora, com o nosso Radar Científico, poderemos aproveitar o conforto da nossa instituição para nos aperfeiçoarmos e assistirmos ao que nos interessa sem deslocamentos para outros locais, como outrora fazíamos por simples desconhecimento do que ocorria aqui.
Aproveitamos ainda o Radar para divulgar e prestigiar aqueles que são nossos protagonistas do ensino: palestrantes, cientistas, autores, mestres, doutores e professores. Tenho a absoluta certeza de que todo o nosso corpo clínico se encaixa em alguma destas funções, pois é isto o que nos segura nas grandes instituições...o ensino! Portanto, nosso Radar Científico serve também para divulgar e prestigiar os grandes professores do Iamspe: vocês!
Pengaruh Modernisasi Sistem Administrasi Perpajakan, Sanksi Pajak dan Kesadaran Wajib Pajak terhadap Kepatuhan Wajib Pajak Orang Pribadi
Authors: Adelia Stevani  , Padriyansyah  , Trie Sartika Pratiwi  
Published: May 2024

Abstract : This research aims to determine the effect of modernization of the tax administration system, tax sanctions and taxpayer awareness on taxpayer compliance at KPP Pratama Palembang Seberang Ulu. To analyze the data, researchers used descriptive statistical tests, validity tests, classical assumption tests (normality test, multicollinearity test and heteroscedasticity test), multiple linear regression, hypothesis tests (t test and F test) and coefficient of determination test (R2). The results of the research show that there is an influence of modernization of the tax administration system, tax sanctions, and taxpayer awareness on individual taxpayer compliance at KPP Pratam Palembang Across Ulu. This is proven by using the F test which shows that the Sig value. 0.000< 0.05. Judging from the results of the partial test, the tax administration system modernization variable does not have a positive effect on taxpayer compliance, while the tax sanctions and taxpayer awareness variables have a positive effect. This test is proven by the t table value being smaller than the calculated t, and the sig value is smaller than 0.05.
Abstrak : Penelitian ini bertujuan untuk mengetahui Pengaruh Modernisasi Sistem Administrasi Perpajakan, Sanksi Pajak, dan Kesadaran Wajib Pajak Terhadap Kepatuhan Wajib Pajak Pada KPP Pratama Palembang Seberang Ulu. Untuk menganalisis data, peneliti menggunakan uji statistik deskritif, uji validitas, uji asumsi klasik (uji normalitas, uji multikolinearitas, dan uji heterokedastisitas), regresi linier berganda, uji hipotesis (uji t dan uji F) dan uji koefisien determinasi (R2 ). Hasil penelitian menunjukkan bahwa terdapat pengaruh modernisasi sistem administrasi pajak, sanksi pajak, dan kesadaran wajib pajak terhadap kepatuhan wajib pajak orang pribadi pada KPP Pratam Palembang seberang Ulu. Hal ini dibuktikan dengan menggunakan Uji F yang menunjukkan bahwa nilai Sig. 0.000< 0.05. Dilihat dari hasil uji parsial diaman variabel modernisasi sistem administrasi perpajakan tidak berpengaruh positif terhadap kepatuhan wajib pajak, sedangkan variabel sanksi pajak dan kesadaran wajib pajak berpengaruh positif, uji ini dibuktikan dari nilai t tabel lebih kecil daripada t hitung, dan nilai sig lebih kecil daripada 0.05.
Precarious Employment and Bonded Labor: Assessment from Agriculture Sector of Punjab (Pakistan)
Authors: Jamshed Farhat , Afzal Afzaal , Anwar Asiya , Arshad Muhammad 
Published: May 2024

Despite strict constitutional provisions and laws existing against bonded labor, the situation is still plagued by this contemporary form of slavery in Pakistan—the trends of bonded labor historically associated with numerous sectors where laborers have to bear precarious employment circumstances. The International Labor Organization estimates that more than 9.5 individuals are forced to engage in bonded labor due to debt bondage, meager employment opportunities, and the absence of adequate implementation of policies in the South Asian region. The prevalence of bounded labor is the product of unawareness, poverty, unavailability of basic human needs, social exclusion, and, above all, the failure of governments to eliminate the practices. This primary study covers three administrative divisions of Punjab, and data was collected through multistage simple random sampling techniques. The interview schedule was used as a tool of data collection and study findings revealed that a considerable proportion of agriculture laborers worked in bounded circumstances. In contrast, the government's writ regarding implementing bounded labor laws is very poor. Due to this unattended situation, agricultural laborers have to face a large number of issues that become significant reasons for morbidity and mortality every year, especially among women and children belonging to these bounded laborers.
Impact of Additional Duties on the Livestock Extension Services in Punjab: A Veterinary Field Staff Perspective
Authors: Asghar Muhammad , Ali Shoukat , Saghir Aqeela , Ahmad Irfan 
Published: May 2024

This study investigates the impact of additional duties of veterinary field staff on the delivery of livestock extension services. The current study was conducted in Punjab province. Administratively, this province consists of nine divisions. All veterinary officers (VOs) and veterinary assistants (VAs) of Punjab were considered as the population of the study. A complete list of veterinary field staff was collected from the Punjab Livestock and Dairy Development Department office. The sample size was calculated with the help of the online sample size calculator www.surveysystem.com with a 5% confidence interval and 95% confidence level. The sample size was drawn through a proportionate simple random sampling technique from two population subgroups, i.e., VOs and VAs. The study results revealed that 85.1% of respondents said they disliked performing the additional duties. About 93% of the respondents reported that the livestock department should have considered their will before assigning additional duties. Additional duties negatively affect the working efficiency of the field staff, as reported by 87.8% of VOs and 93.5% of VAs. Most respondents (58.8%) reported that they have to suspend their routine departmental services upon additional duties. It means, the assignment of additional duties seriously affects the departmental routine extension services. It is suggested that Livestock and Dairy Development, Punjab, should employ exceptional field staff for such additional duties to reduce the extra and irrelevant work burden on veterinary field staff.
Impact of Digital Signage and Social Media Advertising on Consumer Buying Behavior: Mediating Role of Emotional Processes
Authors: Asif Rabia , Naveed Asvir , Farasat Mobina , Khan Majid Imdad 
Published: May 2024

Advertisement plays a major role in company products to attain a competitive edge. Now, companies are commercializing products using social media and digital signage. Over the past decade, social media and digital signage have become promising and greatly influence consumers’ buying behavior. Consumers use social media to communicate with their peers and brands. This study is intended to investigate the role of digital signage and social media advertising on consumer buying behavior with the mediating role of emotional processes. Data was collected using a structured questionnaire and tested using SPSS and AMOS. The study showed a positive and significant relationship between digital signage, social media advertising, and consumer buying behavior. Emotions positively mediate digital signage, social media advertising, and consumer buying behavior relationships