bluuebunny/crossref_metadata_2025_split huggingface dataset:
Intermediate Temperature Anode‐Supported Fuel Cell Based on BaCe0.9Y0.1O3 Electrolyte with Novel Pr2NiO4 Cathode
Authors: Taillades G. , Dailly J. , Taillades‐Jacquin M. , Mauvy F. , Essouhmi A. , Marrony M. , Lalanne C. , Fourcade S. , Jones D. J. , Grenier J.‐C. , Rozière J. 
Published: October 2009

AbstractA proton conducting ceramic fuel cell (PCFC) operating at intermediate temperature has been developed that incorporates electrolyte and electrode materials prepared by flash combustion (yttrium‐doped barium cerate) and auto‐ignition (praseodymium nickelate) methods. The fuel cell components were assembled using an anode‐support approach, with the anode and proton ceramic layers prepared by co‐pressing and co‐firing, and subsequent deposition of the cathode by screen‐printing onto the proton ceramic surface. When the fuel cell was fed with moist hydrogen and air, a high Open Circuit Voltage (OCV > 1.1 V) was observed at T > 550 °C, which was stable for 300 h (end of test), indicating excellent gas‐tightness of the proton ceramic layer. The power density of the fuel cell increased with temperature of operation, providing more than 130 mW cm–2 at 650 °C. Symmetric cells incorporating Ni‐BCY10 cermet and BCY10 electrolyte on the one hand, and Pr2NiO4 + δ and BCY10 electrolyte on the other hand, were also characterised and area specific resistances of 0.06 Ω cm2 for the anode material and 1–2 Ω cm2 for the cathode material were obtained at 600 °C.
Molecular characterization of commonly used cell lines for bone tumor research: A trans‐European EuroBoNet effort
Authors: Ottaviano Laura , Schaefer Karl‐Ludwig , Gajewski Melanie , Huckenbeck Wolfgang , Baldus Stefan , Rogel Uwe , Mackintosh Carlos , de Alava Enrique , Myklebost Ola , Kresse Stine H. , Meza‐Zepeda Leonardo A. , Serra Massimo , Cleton‐Jansen Anne‐Marie , Hogendoorn Pancras C. W. , Buerger Horst , Aigner Thomas , Gabbert Helmut E. , Poremba Christopher 
Published: September 2009

AbstractUsage of cancer cell lines has repeatedly generated conflicting results provoked by differences among subclones or contamination with mycoplasm or other immortal mammalian cells. To overcome these limitations, we decided within the EuroBoNeT consortium to characterize a common set of cell lines including osteosarcomas (OS), Ewing sarcomas (ES), and chondrosarcomas (CS). DNA fingerprinting was used to guarantee the identity of all of the cell lines and to distinguish subclones of osteosarcoma cell line HOS. Screening for homozygous loss of 38 tumor suppressor genes by MLPA revealed deletion of CDKN2A as the most common event (15/36), strictly associated with absence of the CDKN2A (p16) protein. Ten cell lines showed missense mutations of the TP53 gene while another set of nine cell lines showed mutations resulting in truncation of the TP53 protein. Cells harboring missense mutations expressed high levels of nuclear TP53, while cell lines with nonsense mutations showed weak/absent staining for TP53. TP53wt cell lines usually expressed the protein in 2–10% of the cells. However, seven TP53wt osteosarcomas were negative for both mRNA and protein expression. Our analyses shed light on the correlation between immunohistochemical and genetic data for CDKN2A and TP53, and confirm the importance of these signaling pathways. The characterization of a substantial number of cell lines represents an important step to supply research groups with proven models for further advanced studies on tumor biology and may help to make results from different laboratories more comparable. © 2009 Wiley‐Liss, Inc.
Individual sensitivity to pain expectancy is related to differential activation of the hippocampus and amygdala
Authors: Ziv Michal , Tomer Rachel , Defrin Ruth , Hendler Talma 
Published: September 2009

AbstractAnxiety arising during pain expectancy can modulate the subjective experience of pain. However, individuals differ in their sensitivity to pain expectancy. The amygdale and hippocampus were proposed to mediate the behavioral response to aversive stimuli. However, their differential role in mediating anxiety‐related individual differences is not clear. Using fMRI, we investigated brain activity during expectancy to cued or uncued thermal pain applied to the wrist. Following each stimulation participants rated the intensity of the painful experience. Activations in the amygdala and hippocampus were examined with respect to individual differences in harm avoidance (HA) personality trait, and individual sensitivity to expectancy, (i.e. response to cued vs. uncued painful stimuli). Only half of the subjects reported on cued pain as being more painful than uncued pain. In addition, we found a different activation profile for the amygdala and hippocampus during pain expectancy and experience. The amygdala was more active during expectancy and this activity was correlated with HA scores. The hippocampal activity was equally increased during both pain expectancy and experience, and correlated with the individual's sensitivity to expectancy. Our findings suggest that the amygdala supports an innate tendency to approach or avoid pain as reflected in HA trait, whereas the hippocampus mediates the effect of context possibly via appraisal of the stimulus value. Hum Brain Mapp, 2010. © 2009 Wiley‐Liss, Inc.
Laryngeal inflammatory myofibroblastic tumors: Different clinical appearance and histomorphologic presentation of one entity
Authors: Völker Hans‐Ullrich , Scheich Matthias , Zettl Andreas , Hagen Rudolf , Müller‐Hermelink Hans Konrad , Gattenlöhner Stefan 
Published: September 2009

AbstractBackgroundInflammatory myofibroblastic tumors (IMFTs) of the larynx are rare. We report the clinical presentation, histomorphology, and new molecular findings of 2 cases.MethodsParaffin‐embedded specimens were stained immunohistochemically (eg, vimentin, AE1/3, Alk‐1, smooth muscle [sm‐]actin, p53, Rb1, immunoglobulin G4 [IgG4]). Epstein–Barr virus–encoded RNA (EBER) in situ hybridization and HHV8–polymerase chain reaction (PCR) were done. Comparative genomic hybridization (CGH) was performed.ResultsCase 1 was that of a 56‐year‐old man with an infiltrating plasma‐cell–rich tumor (Alk‐1‐, sm‐actin+). Plasma cells were strongly positive for IgG4. CGH was unsuspicious. Case 2 was that of a 34‐year‐old woman with an exophytic tumor (Alk‐1+). CGH revealed losses on 13q14–22. The few plasma cells were negative for IgG4. The proliferation (Ki67) was low in both cases.ConclusionDifferent types of IMFTs may exist and could indicate different therapeutic strategies. Alk‐1‐positive cases with only scattered inflammatory cells could represent the neoplastic variant, whereas cases rich in plasma cells could be associated with IgG4 sclerosing diseases. © 2009 Wiley Periodicals, Inc. Head Neck, 2009
Dendritic cells pulsed with GST–EGFR fusion protein: Effect in antitumor immunity against head and neck squamous cell carcinoma
Authors: Yang Bei‐Bei , Jiang Hua , Chen Jia , Zhang Xing , Ye Jing‐Jia , Cao Jiang 
Published: September 2009

AbstractBackgroundOverexpression of epidermal growth factor receptor (EGFR) is common in head and neck squamous cell carcinoma (HNSCC). Targeting EGFR is an effective approach to treat EGFR‐positive HNSCC. However, the clinical benefits of the present EGFR‐targeting agents are still limited in HNSCC patients.MethodsRecombinant glutathione‐S‐transferase (GST)–EGFR fusion protein was produced and purified. Dendritic cells (DCs) of C3H mice were pulsed with fusion protein. Mice were challenged with HNSCC cells before or after vaccination with these DCs, and the cytotoxic T‐lymphocyte (CTL) response, interferon‐γ (IFN‐γ) secretion, tumor growth, and survival of mice were assessed.ResultsSignificant in vitro and in vivo antitumor activities were observed for mice immunized with DCs pulsed with GST–EGFR fusion protein, compared with the control groups (p < .05).ConclusionThe DCs pulsed with GST–EGFR fusion protein can provide not only preventive but also therapeutic antitumor activities against HNSCC in the animal model. © 2009 Wiley Periodicals, Inc. Head Neck, 2010
Nonparotid parapharyngeal oncocytoma: A case report and literature review
Authors: Barrese James L. , Lau Sean , Chen Bihong T. , Maghami Ellie 
Published: September 2009

AbstractOncocytoma is a rare, benign salivary neoplasm composed of mitochondria‐rich cells called oncocytes. Although oncocytoma usually occurs in the parotid glands, it has much less commonly been reported to occur in minor salivary gland tissues. Although there have been a few reported cases of oncocytomas being found in the parapharyngeal space, most if not all cases seem to be extensions of deep lobe parotid tumors. We present a case of a 73‐year‐old man with a previous history of prostate cancer that had the incidental finding of an 18F‐fluorodeoxyglucose (FDG) image of a highly avid parapharyngeal space lesion noted on a follow‐up positron emission tomography–computed tomography (PET/CT) scan. Excision of the mass, through a transcervical approach, demonstrated it to be an isolated oncocytoma of the parapharyngeal space, noncontiguous with the parotid gland. Based on our literature search, this may be the first such reported case. A brief review of the available literature examining the known body of knowledge regarding these neoplasms is presented. © 2009 Wiley Periodicals, Inc. Head Neck, 2010
UltraCision harmonic scalpel versus clamp‐and‐tie total thyroidectomy: A clinical trial
Authors: Papavramidis Theodossis S. , Sapalidis Konstantinos , Michalopoulos Nick , Triantafillopoulou Konstantina , Gkoutzamanis George , Kesisoglou Isaak , Papavramidis Spiros T. 
Published: September 2009

AbstractBackgroundHemostasis is important in thyroid surgery to avoid complications. Our aim was to evaluate the effectiveness of the harmonic scalpel in patients undergoing total thyroidectomy.MethodsIn this study, 90 patients were randomized into group A (classic technique of tying and knots) and group B (harmonic scalpel). We recorded the following: age, sex, pathology, thyroid weight, hemostatic technique, duration of operation, change in calcemia (ΔCa), change in hematocrit (ΔHt), change in hemoglobin (ΔHgb), change in white blood cell count (ΔWBC), vocal motility, operative difficulty, postoperative vocal alteration, postoperative pain, complications, blood in the drains, operating time, mass of gland excised per minute, and hospitalization.ResultsDifferences (p < .05) were observed concerning duration of surgery, operative difficulty, postoperative pain, hospitalization, ΔWBC, and quantity of gland removed per minute. No recurrent laryngeal nerve (RLN) palsies were observed.ConclusionsUse of the Harmonic Scalpel in total thyroidectomy is more effective than the clamp‐and‐tie technique: the duration of surgery, intraoperative difficulty, postoperative pain, and hospitalization are reduced. Both techniques are equivalent concerning RLN injuries, postoperative vocal alterations, and blood loss. © 2009 Wiley Periodicals, Inc. Head Neck, 2010
Aging alters the expression of genes for neuroprotection and synaptic function following acute estradiol treatment
Authors: Aenlle Kristina K. , Foster Thomas C. 
Published: September 2009

AbstractThis study used microarray analysis to examine age‐related changes in gene expression 6 and 12 h following a single estradiol injection in ovariectomized mice. Estradiol‐responsive gene expression at the 6 h time point was reduced in aged (18 months) animals compared with young (4 months) and middle‐aged (MA, 12months) mice. Examination of gene clustering within biological and functional pathways indicated that young and MA mice exhibited increased expression of genes for cellular components of the synapse and decreased expression of genes related to oxidative phosphorylation and mitochondrial dysfunction. At the 12 h time point, estradiol‐responsive gene expression increased in aged animals and decreased in young and MA mice compared with the 6 h time point. Gene clustering analysis indicated that aged mice exhibited increased expression of genes for signaling pathways that are rapidly influenced by estradiol. The age differences in gene expression for rapid signaling pathways may relate to disparity in basal pathway activity and estradiol mediated activation of rapid signaling cascades. © 2009 Wiley‐Liss, Inc.
Effects of switching to long‐acting injectable risperidone from oral atypical antipsychotics on cognitive function in patients with schizophrenia
Authors: Kim Sung‐Wan , Shin Il‐Seon , Kim Jae‐Min , Lee Seung‐Hyun , Lee Yo‐Han , Yang Su‐Jin , Yoon Jin‐Sang 
Published: September 2009

AbstractObjectiveTo investigate changes in cognitive function and clinical features following a switch from oral atypical antipsychotics (AAPs) to long‐acting injectable risperidone (LAIR) in patients with schizophrenia.MethodsThirty‐six patients with schizophrenia treated with oral AAPs participated in this open‐label, 26‐week study. Cognitive functions were measured at baseline and at 12 and 26 weeks. The secondary outcome measures included the Positive and Negative Syndrome Scale (PANSS), Social and Occupational Functioning Assessment Scale (SOFAS), Scale for Unawareness of Mental Disorder (SUMD), and measurements for extrapyramidal symptoms.ResultsSignificant improvements in cognitive function were observed in the backward Digit Span Test, Verbal Learning Test, Wisconsin Card Sorting Test, correct responses on the Continuous Performance Test, and Trail Making Test part B following a switch to LAIR. Scores on the PANSS, SOFAS, SUMD, and the Simpson–Angus Rating Scale also improved significantly. Most improvements in neurocognitive function were not correlated with clinical measures. Weight gain and hyperprolactinemia were the most common adverse events.ConclusionsSwitching from oral AAPs to LAIR improved cognitive function including vigilance, verbal learning and memory, executive function, sustained attention, and visuomotor speed in patients with schizophrenia. It was also effective for improving psychotic symptoms, social functioning, and insight. Copyright © 2009 John Wiley & Sons, Ltd.
Effect of coastline configuration on precipitation distribution in coastal zones
Authors: Eris Ebru , Agiralioglu Necati 
Published: September 2009

AbstractThe effects of coastline, together with the other geographical and topographical factors such as longitude, latitude, elevation and distance from sea, on mean annual precipitation are investigated for the coastal area of the eastern Black Sea region. In this location, mountains run parallel to the sea coast. The coastline configuration is represented by a new variable, the coastline angle. A multiple linear regression (MLR) analysis is performed on mean annual precipitation recorded in coastal and inland gauges. In the study area, three variables—longitude, latitude and coastline angle—can explain 81% of the spatial variability of precipitation for the coastal gauges and 93% of that for the inland gauges. When the entire study area considered, without grouping the gauges, 80% of the spatial variability is explained by these variables. Copyright © 2009 John Wiley & Sons, Ltd.
Cigarette smoking, environmental tobacco smoke exposure and pancreatic cancer risk in the European Prospective Investigation into Cancer and Nutrition
Authors: Vrieling Alina , Bueno‐de‐Mesquita H. Bas , Boshuizen Hendriek C. , Michaud Dominique S. , Severinsen Marianne T. , Overvad Kim , Olsen Anja , Tjønneland Anne , Clavel‐Chapelon Françoise , Boutron‐Ruault Marie‐Christine , Kaaks Rudolf , Rohrmann Sabine , Boeing Heiner , Nöthlings Ute , Trichopoulou Antonia , Moutsiou Eftihia , Dilis Vardis , Palli Domenico , Krogh Vittorio , Panico Salvatore , Tumino Rosario , Vineis Paolo , van Gils Carla H. , Peeters Petra H.M. , Lund Eiliv , Gram Inger T. , Rodríguez Laudina , Agudo Antonio , Larrañaga Nerea , Sánchez María‐José , Navarro Carmen , Barricarte Aurelio , Manjer Jonas , Lindkvist Björn , Sund Malin , Ye Weimin , Bingham Sheila , Khaw Kay‐Tee , Roddam Andrew , Key Tim , Boffetta Paolo , Duell Eric J. , Jenab Mazda , Gallo Valentina , Riboli Elio 
Published: September 2009

AbstractCigarette smoking is an established risk factor for pancreatic cancer. However, prospective data for most European countries are lacking, and epidemiologic studies on exposure to environmental tobacco smoke (ETS) in relation to pancreatic cancer risk are scarce. We examined the association of cigarette smoking and exposure to ETS with pancreatic cancer risk within the European Prospective Investigation into Cancer and Nutrition (EPIC). This analysis was based on 465,910 participants, including 524 first incident pancreatic cancer cases diagnosed after a median follow‐up of 8.9 years. Estimates of risk were obtained by Cox proportional hazard models and adjusted for weight, height, and history of diabetes mellitus. An increased risk of pancreatic cancer was found for current cigarette smokers compared with never smokers (HR = 1.71, 95% CI = 1.36–2.15), and risk increased with greater intensity and pack‐years. Former cigarette smokers who quit for less than 5 years were at increased risk of pancreatic cancer (HR = 1.78, 95% CI = 1.23–2.56), but risk was comparable to never smokers after quitting for 5 years or more. Pancreatic cancer risk was increased among never smokers daily exposed to ETS (for many hours) during childhood (HR = 2.61, 95% CI = 0.96–7.10) and exposed to ETS at home and/or work (HR = 1.54, 95% CI = 1.00–2.39). These results suggest that both active cigarette smoking, as well as exposure to ETS, is associated with increased risk of pancreatic cancer and that risk is reduced to levels of never smokers within 5 years of quitting.
Contrast‐enhanced ultrasound with SonoVue: Differentiation between benign and malignant focal liver lesions in 317 patients
Authors: von Herbay Alexandra , Westendorff Julia , Gregor Michael 
Published: September 2009

AbstractPurpose.The aim of the study was to investigate the ability of contrast‐enhanced sonography (CEUS) with the contrast agent SonoVue to differentiate between benign and malignant focal liver lesions.Methods.In a prospective study, we examined 317 patients (204 males, 113 females, aged 59 ± 12 years) with focal liver lesions detected by B‐mode gray‐scale sonography. After intravenous injection of 1.2 mL SonoVue, the liver was examined continuously for 3 minutes using low‐MI sonography with contrast‐specific software. Final diagnosis was established by histopathology, CT, MRI, or HIDA‐scintigraphy.Results.Two hundred nine patients had malignant focal lesions, including 107 hepatocellular carcinomas, 70 metastases, 26 cholangiocellular carcinomas, and 6 other types of malignancy. One hundred eight patients had benign focal lesions, including 30 regenerative nodules, 30 hemangiomas, 13 cases of focal nodular hyperplasia, 12 abscesses, 8 cases of necrosis, 7 cases of focal steatosis areas, and 8 other benign lesions. Hypoenhancement or no enhancement in the late phase was found in 91% of the malignant lesions but in only 37% of the benign lesions (p < 0.001, sensitivity = 64%, specificity = 93%). Hyperenhancement in the late phase was found in 20% of the benign lesions but in none of the malignant lesions (p < 0.001, sensitivity = 21%, specificity = 100%). Hyperenhancement in the early phase with diffuse complete enhancement was found in 30% of the patients with malignant lesions but in only 2% of the patients with benign lesions (p < 0.001, sensitivity = 30%, specificity = 98%). CEUS had a sensitivity of 90%, a specificity of 99%, and an accuracy of 89% in the diagnosis of malignant liver lesions.Conclusion.CEUS is helpful in the differentiation between benign and malignant focal liver lesions. © 2009 Wiley Periodicals, Inc. J Clin Ultrasound, 2010
Retracted:Evidence for duplicated Hox genes in polyploid Cyprinidae fish of common carp, crucian carp and silver crucian carp
Authors: Yuan Jian , He Zhuzi , Yuan Xiangnan , Jiang Xiayun , Sun Xiaowen , Zou Shuming 
Published: September 2009

AbstractNotice of Withdrawal: The following article from the Journal of Experimental Zoology Part B: Molecular and Developmental Evolution, “Evidence for duplicated Hox genes in polyploid Cyprinidae fish of common carp, crucian carp, and silver crucian carp” by Yuan J, He Z, Yuan X, Jiang X, Sun X, Zou S, published online on 29 Sept 2009 in Wiley InterScience (www.interscience.wiley.com), has been withdrawn from publication by agreement between the authors, the journal Editor‐in‐Chief, Gunter P. Wagner, and Wiley Periodicals, Inc.
Top heavy? Governance issues and policy decisions for the fair trade movement
Authors: Tallontire Anne 
Published: September 2009

AbstractWith the advent of mainstreaming, several different business models operate within the fair trade system. These differences are discussed in terms of how the value chain is governed, suggesting the need for a more nuanced understanding of fair trade in the mainstream. Institutional governance, that is, the structures and standards of fair trade, is also discussed. It is argued that if fair trade is to be more than just another consumer standard, it needs to address both value chain and institutional governance. Policy implications, especially with respect to fair trade institutions, particularly Fairtrade Labelling Organisations International, are set out. Copyright © 2009 John Wiley & Sons, Ltd.
Reduced size of the dendritic tree does not protect Purkinje cells from excitotoxic death
Authors: Gugger Olivia S. , Kapfhammer Josef P. 
Published: October 2009

AbstractPurkinje cell loss by excitotoxic damage is a typical finding in many cerebellar diseases. One important aspect of this high sensitivity of Purkinje cells to excitotoxic death might be the enormous size of their dendritic tree, with a high load of excitatory glutamate receptors. We have studied whether reduction in the size of the dendritic tree might confer resistance against excitotoxic death to Purkinje cells. We have grown Purkinje cells in organotypic cerebellar slice cultures under chronic activation of metabotropic glutamate receptors or of protein kinase C. Both treatments strongly reduced dendritic tree size. After this treatment, cells were exposed to the glutamate receptor agonist AMPA, which has a strong excitotoxic effect on Purkinje cells. We found that Purkinje cells with small dendritic trees were as sensitive to AMPA exposure as untreated control cells with large dendritic trees. Immunostaining against vesicular glutamate transporter 1 revealed that the small dendritic trees were densely covered by glutamatergic terminals. Our results indicate that the expansion of the dendritic tree and the total number of AMPA receptors per neuron do not play a major role in determining the susceptibility of Purkinje cells to excitotoxic death. © 2009 Wiley‐Liss, Inc.
Influence of the Madden–Julian Oscillation on Indonesian rainfall variability in austral summer
Authors: Hidayat Rahmat , Kizu Shoichi 
Published: September 2009

AbstractThe impact of the Madden–Julian Oscillation (MJO) on Indonesian rainfall variability in austral summer is analysed by using the daily station rain gauge data and Tropical Rainfall Measuring Mission precipitation data for the periods of 1979 through 1990 and 1998 through 2006, respectively. Composite analysis of 21 and 16 MJO events identified in former respective periods shows that the rainfall variability over Indonesia is significantly affected by the phase of eastward‐propagating MJO. Excess rainfall is brought during ‘wet’ phase, when the convective activity reaches its maximum with enhanced low‐level wind convergence over the region. In addition, the impact of MJO tends to be more profound over the surrounding seas than over the large islands of this region. The positive rainfall anomaly over the eastern Indian Ocean and Java Sea during the wet phase is up to 5 mm/day (60% of the long‐term mean) as a pentad mean, while it is about 1–3 mm/day (10–30%) over Borneo and Java. Copyright © 2009 Royal Meteorological Society