bluuebunny/crossref_metadata_2025_split huggingface dataset:
SuperAging functional connectomics from resting-state functional MRI
Authors: Diamond Bram R , Sridhar Jaiashre , Maier Jessica , Martersteck Adam C , Rogalski Emily J 
Published: June 2024

Abstract
Understanding the relationship between functional connectivity (FC) of higher-order neurocognitive networks and age-related cognitive decline is a complex and evolving field of research. Decreases in FC have been associated with cognitive decline in persons with Alzheimer’s disease and related dementias (ADRD). However, the contributions of FC have been less straightforward in typical cognitive aging. Some investigations suggest relatively robust FC within neurocognitive networks differentiates unusually successful cognitive aging from average aging, while others do not. Methodologic limitations in data processing and varying definitions of ‘successful aging’ may have contributed to the inconsistent results to date. The current study seeks to address previous limitations by optimized MRI methods to examine FC in the well-established SuperAging phenotype, defined by age and cognitive performance as individuals 80 and older with episodic memory performance equal to or better than 50-to-60-year-olds. Within- and between-network FC of large-scale neurocognitive networks were compared between 24 SuperAgers and 16 cognitively average older-aged control (OACs) with stable cognitive profiles using resting-state functional MRI (rs-fMRI) from a single visit. Group classification was determined based on measures of episodic memory, executive functioning, verbal fluency and picture naming. Inclusion criteria required stable cognitive status across two visits. First, we investigated the FC within and between seven resting-state networks from a common atlas parcellation. A separate index of network segregation was also compared between groups. Second, we investigated the FC between six subcomponents of the default mode network (DMN), the neurocognitive network commonly associated with memory performance and disrupted in persons with ADRD. For each analysis, FCs were compared across groups using two-sample independent t-tests and corrected for multiple comparisons. There were no significant between-group differences in demographic characteristics including age, sex and education. At the group-level, within-network FC, between-network FC, and segregation measurements of seven large-scale networks, including subcomponents of the DMN, were not a primary differentiator between cognitively average aging and SuperAging phenotypes. Thus, FC within or between large-scale networks does not appear to be a primary driver of the exceptional memory performance observed in SuperAgers. These results have relevance for differentiating the role of FC changes associated with cognitive aging from those associated with ADRD.
Basal temporal language area revisited in Japanese language with a language function density map
Authors: Matoba Kento , Matsumoto Riki , Shimotake Akihiro , Nakae Takuro , Imamura Hisaji , Togo Masaya , Yamao Yukihiro , Usami Kiyohide , Kikuchi Takayuki , Yoshida Kazumichi , Matsuhashi Masao , Kunieda Takeharu , Miyamoto Susumu , Takahashi Ryosuke , Ikeda Akio 
Published: June 2024

Abstract
We revisited the anatomo-functional characteristics of the basal temporal language area (BTLA), first described by Lüders et al. (1986), using electrical cortical stimulation (ECS) in the context of Japanese language and semantic networks. We recruited 11 patients with focal epilepsy who underwent chronic subdural electrode implantation and ECS mapping with multiple language tasks for presurgical evaluation. A semiquantitative language function density map delineated the anatomo-functional characteristics of the BTLA (66 electrodes, mean 3.8 cm from the temporal tip). The ECS-induced impairment probability was higher in the following tasks, listed in a descending order: spoken-word picture matching, picture naming, Kanji word reading, paragraph reading, spoken-verbal command, and Kana word reading. The anterior fusiform gyrus (FG), adjacent anterior inferior temporal gyrus (ITG), and the anterior end where FG and ITG fuse, were characterized by stimulation-induced impairment during visual and auditory tasks requiring verbal output or not, whereas the middle FG was characterized mainly by visual input. The parahippocampal gyrus was the least impaired of the three gyri in the basal temporal area. We propose that the BTLA has a functional gradient, with the anterior part involved in amodal semantic processing and the posterior part, especially the middle FG in unimodal semantic processing.
Money and Its Body in the Social Positioning and Credit Perspectives: Review Article of Samuel A. Chambers’ Money has No Value
Authors: Pratten Stephen 
Published: June 2024

Abstract
A new and distinctive version of the credit theory of money is advanced by Samuel A. Chambers in his book Money Has No Value. The account of money sponsored by social positioning theory is an alternative perspective against which Chambers’ new credit theory can be productively compared. This review article draws out the differences between these competing theories of the nature of money. An examination of Chambers’ brief, largely dismissive, remarks on social positioning theory reveals a flawed conception of it. The social positioning theory of money is shown to be a coherent and explanatorily powerful account that is worthy of consideration alongside even the updated version of the credit theory supplied by Chambers.
An unusual case of two acute coronary syndrome episodes caused by allergic and non-allergic coronary artery dissection with potential coronary vasospasm association: a case report
Authors: Yoshino Tomohiro , Yunoki Kei , Miyahara Katsunori , Ida Jun , Oka Takefumi 
Published: June 2024

Abstract

Background
Type I variant Kounis syndrome is characterized by coronary spasm following an allergic or anaphylactic reaction. Coronary spasm is also recognized as a contributing factor in spontaneous coronary artery dissection (SCAD).

Case summary
A 46-year-old woman presented to the emergency room with a chief complaint of chest discomfort following the ingestion of a steamed bun. A marked decrease in systolic blood pressure and a prominent rash on her forearms and groin suggested anaphylactic shock. Upon stabilization of vital signs, acute coronary syndrome (ACS) was suspected based on electrocardiogram findings and symptoms, prompting an emergency coronary angiography (CAG). The CAG revealed severe stenosis with coronary artery dissection in the right coronary artery (RCA), and a stent implantation was performed. Given the suspicion of type I variant Kounis syndrome, a spasm provocation test was performed, yielding a positive result. Six years later, she experienced chest discomfort while sleeping and was admitted to our emergency department. An electrocardiogram showed ST-segment elevation in leads II, III, and aVF. An emergency CAG identified a severely stenotic lesion with coronary artery dissection in the RCA, leading to a diagnosis of SCAD. Direct stenting was performed at the stenotic site. The patient was discharged following intensification of medication.

Discussion
This report describes a rare case of a middle-aged woman with two episodes of ACS caused by both allergic and non-allergic coronary artery dissection. These episodes suggest that a shared underlying coronary vasospasm in both conditions may be a common trigger for coronary artery dissection.
What’s in a name? Using species delimitation to inform conservation practice for Chinese giant salamanders (Andrias spp.)
Authors: Marr Melissa M , Hopkins Kevin , Tapley Benjamin , Borzée Amaël , Liang Zhiqiang , Cunningham Andrew A , Yan Fang , Wang Jie , Turvey Samuel T 
Published: June 2024

Abstract
Genetically-defined biodiversity units must align with practical conservation frameworks, and most conservation is conducted at the species level. Chinese giant salamanders have traditionally been interpreted as the single widespread species Andrias davidianus, but molecular studies have reinterpreted this taxon as representing multiple allopatric clades, and competing taxonomic hypotheses support different numbers of candidate species. We conducted species delimitation analyses using tree-based models (General Mixed Yule Coalescent, Poisson Tree Processes) and alignment-based models (Bayesian Phylogenetics and Phylogeography) to interpret diversification across Andrias within a comparative systematic framework, using 30 mitogenomes representing all recognised Chinese clades. Nearly all tested models provide support for at least seven statistically-resolved Chinese species-level lineages, and most provide support for nine species. Only four species have available names. Chinese Andrias populations are Critically Endangered, but unnamed species cannot be incorporated into national or international conservation frameworks and risk being excluded from recovery efforts. We urge taxonomists and conservation practitioners to focus more attention on the world’s largest amphibians, and non-standard taxonomic approaches may be required to name these species before they disappear.
Evaluating the potential for continuous update of enhanced forest inventory attributes using optical satellite data
Authors: Mulverhill Christopher , Coops Nicholas C , White Joanne C , Tompalski Piotr , Achim Alexis 
Published: June 2024

Abstract
Timely and detailed inventories of forest resources are of critical importance to guiding sustainable forest management decisions. As forests occur across large spatial extents, remotely sensed data are often used to augment conventional forest inventory measurements. When combined with field plot measurements, airborne laser scanning (ALS) data can be used to derive detailed enhanced forest inventories (EFIs), which provide spatially explicit and wall-to-wall characterizations of forest attributes. However, these EFIs represent a static point in time, and the dynamic nature of forests, coupled with increasing disturbance and uncertain future conditions, generates a need for the continuous updating of forest inventories. This study used a time series of optical satellite data to update an EFI generated for a large (~690 000 ha) forest management unit in Ontario, Canada, at a two-week interval. The two-phase approach involved first building a relationship between single-year EFI attributes (2018) and spectral variables representing within-year slope, amplitude, and trend of a time series (2000–21) of 14 spectral bands and indices. For each of the 20 strata representing different species groups and site productivity classes, a k-nearest neighbor (kNN) model was developed to impute seven common EFI attributes: aboveground biomass, basal area, stem density, Lorey’s height, quadratic mean diameter, and stem volume. Across all strata, models were generally accurate, with relative root mean square error ranging from 11.47% (canopy cover) to 31.82% (stem volume). In the second phase of the approach, models were applied across the entire study area at two-week intervals in order to assess the capacity of the methodology for characterizing change in EFI attributes over a three-year period. Outputs from this second phase demonstrated the potential of the approach for characterizing changes in EFI values in areas experiencing no change or non-stand replacing disturbances. The methods developed herein can be used for EFI update for any temporal interval, thereby enabling more informed decisions by forest managers to prescribe treatments or understand the current state of forest resources.
Evaluating Performance of Different RNA Secondary Structure Prediction Programs Using Self-cleaving Ribozymes
Authors: Qi Fei , Chen Junjie , Chen Yue , Sun Jianfeng , Lin Yiting , Chen Zipeng , Kapranov Philipp 
Published: June 2024

Abstract
Accurate identification of the correct, biologically relevant RNA structures is critical to understanding various aspects of RNA biology since proper folding represents the key to the functionality of all types of RNA molecules and plays pivotal roles in many essential biological processes. Thus, a plethora of approaches have been developed to predict, identify, or solve RNA structures based on various computational, molecular, genetic, chemical, or physicochemical strategies. Purely computational approaches hold distinct advantages over all other strategies in terms of the ease of implementation, time, speed, cost, and throughput, but they strongly underperform in terms of accuracy that significantly limits their broader application. Nonetheless, the advantages of these methods led to a steady development of multiple in silico RNA secondary structure prediction approaches including recent deep learning-based programs. Here, we compared the accuracy of predictions of biologically relevant secondary structures of dozens of self-cleaving ribozyme sequences using seven in silico RNA folding prediction tools with tasks of varying complexity. We found that while many programs performed well in relatively simple tasks, their performance varied significantly in more complex RNA folding problems. However, in general, a modern deep learning method outperformed the other programs in the complex tasks in predicting the RNA secondary structures, at least based on the specific class of sequences tested, suggesting that it may represent the future of RNA structure prediction algorithms.
Digestive Enzyme Activities in Mussel Mytilus californianus Endure Acute Heat Exposure in Air
Authors: Rankins Daniel , Connor Kwasi M , Bryant Emily E , Lopez Jonathan , Nieves Diana L , Moran Matthew , Wehrle Beck A 
Published: June 2024

Synopsis
The mussel Mytilus californianus is an ecosystem engineer forming beds along the coastlines of Northeastern Pacific shores. As sessile organisms, they modulate their energy balance through valve movements, feeding, and digestive functionality. A recent study observed that activity of the digestive enzyme cellulase was higher than predicted in mussels high on the shore, where temperatures are characteristically high and food availability is limited compared to low-shore habitats. In the current study, we predicted that this scavenging behavior is induced to mitigate energy losses related to heat-shock responses—that cellulase and amylase will display hyperactivity for limited recourses in the face of aerial heating. In the laboratory, we acclimated mussels to three complex diets that differed in starch and cellulose composition, followed by two acute heat shocks (+8°C) in the laboratory. Results showed no hyperactivity of amylase and cellulase in heated mussels. These results differ from previous studies that showed lowered amylase activity following heat acclimation. This difference in amylase activity across heat-stress exposure time is important when analyzing mussel bed disturbances following heat waves that compromise energy balance or cause death within adult populations.
Antibiotic prescribing and bacterial infection in COVID-19 inpatients in Southeast Asia: a systematic review and meta-analysis
Authors: Chanapal Achiraya , Cheng Hung-Yung , Lambert Helen , Cong Wenjuan 
Published: June 2024

Abstract

Background
The prescribing of antibiotics to treat COVID-19 patients has been observed to occur frequently, often without clear justification. This trend raises concerns that it may have exacerbated antimicrobial resistance (AMR). Despite longstanding concerns over AMR in Southeast Asian countries, data on this issue are notably lacking.

Objectives
To explore the impact of COVID-19 on antibiotic prescribing, bacterial infection prevalence and common resistant pathogens in COVID-19 inpatients.

Methods
We searched PubMed, EMBASE, Web of Science and ThaiJO (a Thai academic database) to identify studies conducted in ASEAN member countries and published between December 2019 and March 2023. Screening and data extraction were done by two independent reviewers, with results synthesized using random-effects meta-analyses and descriptive statistical analyses. This review was registered with PROSPERO (CRD42023454337).

Results
Of the 29 studies (19 750 confirmed COVID-19 cases) included for final analysis, the antibiotic prescribing rate was 62.0% (95%CI: 46.0%–76.0%) with a prescribing rate of 58.0% (21.0%–91.0%) in mild/moderate cases versus 91.0% (82.0%–98.0%) in severe/critical cases. Notably, 80.5% of antibiotics prescribed fall under the WHO AWaRe ‘Watch’ list, followed by ‘Access’ at 18.4% and ‘Reserve’ at 1.0%. The reported bacterial infection prevalence was 16.0% (7.0%–29.0%), with Acinetobacter baumannii being the most common resistant bacterium at 7.7%. Singapore was notable for its lower antibiotic prescribing rate of 17.0% and a lower bacterial infection rate of 10.0%.

Conclusions
High antibiotic prescribing rates, disproportionate to bacterial infections and varying practices for COVID-19 inpatients across countries highlight the urgent need for this region to collaborate to tackle and mitigate AMR.
Non-prescription sale and dispensing of antibiotics for prophylaxis in broiler chickens in Lusaka District, Zambia: findings and implications on one health
Authors: Mudenda Steward , Mulenga Karen Mubanga , Nyirongo Ruth , Chabalenge Billy , Chileshe Chikwanda , Daka Victor , M’kandawire Ethel , Jere Elimas , Muma John Bwalya 
Published: June 2024

Abstract

Background
The irrational use of antibiotics in humans and livestock has contributed to the emergence of antimicrobial resistance (AMR). This study investigated the commonly sold and dispensed antibiotics for prophylaxis in broiler chickens in pharmacy and agro-veterinary shop personnel in the Lusaka District of Zambia.

Methods
This cross-sectional study was conducted from August 2023 to October 2023 among 200 veterinary medicine dispensers in the Lusaka District of Zambia using a simulated farmer or mystery shopper approach. Data analysis was performed using IBM Statistical Package for Social Sciences version 23.0.

Results
Out of the 200 medicine outlets investigated, 23 (11.5%) were agro-veterinary shops, while 177 (88.5%) were community pharmacies. A total of 165 community pharmacies and agro-veterinary shops provided veterinary services in the Lusaka District and sold medicines without prescription giving a 100% non-prescription sale. Of the 178 medicines dispensed for prophylaxis, 88.5% were antibiotics, while 13.5% were vitamins. The most dispensed antibiotic drug for prophylaxis in broiler chickens was oxytetracycline (30.34%), amoxicillin (17.98%) and gentamicin/doxycycline (10.67%).

Conclusions
This study revealed a high sale and dispensing of antibiotics for prophylaxis in broiler chickens of which oxytetracycline, amoxicillin and gentamicin/doxycycline were commonly dispensed. There is a need for increased regulatory enforcement of selling antibiotics without a prescription as this may predispose poultry to the development of AMR and possible transmission of superbugs to humans and the environment. Educational interventions should be provided to community pharmacy and agro-veterinary personnel on adhering to antimicrobial stewardship practices when dispensing poultry antibiotics.
The inhibition mechanism of co-cultured probiotics on biofilm formation of Klebsiella pneumoniae
Authors: Zhang Chaolei , Wang Chao , Dai Jianying , Xiu Zhilong 
Published: June 2024

Abstract

Aims
Klebsiella pneumoniae, an important opportunistic pathogen of nosocomial inflection, is known for its ability to form biofilm. The purpose of the current study is to assess how co- or mono-cultured probiotics affect K. pneumoniae’s ability to produce biofilms and investigate the potential mechanisms by using a polyester nonwoven chemostat and a Caco-2 cell line.

Methods and Results
Compared with pure cultures of Lactobacillus rhamnosus and Lactobacillus sake, the formation of K. pneumoniae biofilm was remarkably inhibited by the mixture of L. rhamnosus, L. sake, and Bacillus subtilis at a ratio of 5:5:1 by means of qPCR and FISH assays. In addition, Lactobacillus in combination with B. subtilis could considerably reduce the adherence of K. pneumoniae to Caco-2 cells by using inhibition, competition, and displacement assays. According to the RT-PCR assay, the adsorption of K. pneumoniae to Caco-2 cells was effectively inhibited by the co-cultured probiotics, leading to significant reduction in the expression of proinflammatory cytokines induced by K. pneumoniae. Furthermore, the HPLC and RT-PCR analyses showed that the co-cultured probiotics were able to successfully prevent the expression of the biofilm-related genes of K. pneumoniae by secreting plenty of organic acids as well as the second signal molecule (c-di-GMP), resulting in inhibition on biofilm formation.

Conclusion
Co-culture of L. sake, L. rhamnosus, and B. subtilis at a ratio of 5:5:1 could exert an antagonistic effect on the colonization of pathogenic K. pneumoniae by down-regulating the expression of biofilm-related genes. At the same time, the co-cultured probiotics could effectively inhibit the adhesion of K. pneumoniae to Caco-2 cells and block the expression of proinflammatory cytokines induced by K. pneumoniae.
Effect of an organic acid blend as an antibiotic alternative on growth performance, antioxidant capacity, intestinal barrier function, and fecal microbiota in weaned piglets
Authors: Cai Long , Zhao Ying , Chen Wenning , Li Yanpin , Han Yanming , Zhang Bo , Pineda Lane , Li Xilong , Jiang Xianren 
Published: June 2024

Abstract
This study was conducted to evaluate the effects of dietary organic acid blend on growth performance, antioxidant capacity, intestinal barrier function, and fecal microbiota in weaned piglets compared with antibiotic growth promoters (AGPs). A total of 90 weaned crossbred barrows (24 ± 1 d of age) with an initial body weight of 7.40 kg were allocated into three experimental treatments. Each treatment consisted of six replicate pens, with five piglets housed in each pen. The dietary treatments included the basal diet (NC), the basal diet supplemented with antibiotics (PC), and the basal diet supplemented with organic acid blend (OA). On day 42, one piglet per pen was randomly selected for plasma and small intestinal sample collection. The results showed that dietary AGP significantly improved growth performance and reduced diarrhea incidence compared to the NC group (P &lt; 0.05). Dietary OA tended to increase body weight on day 42 (P = 0.07) and average daily gain from days 0 to 42 (P = 0.06) and reduce diarrhea incidence (P = 0.05). Dietary OA significantly increased plasma catalase (CAT) activity and decreased the plasma concentration of malondialdehyde (MDA), tumor necrosis factor-α (TNF-α), interleukin (IL)-8, and IL-6, which were accompanied by upregulated the relative mRNA abundance of superoxide dismutase 1 (SOD1), glutathione peroxidase 1 (GPX1), and nuclear factor erythroid 2-related factor 2 (NRF2) in comparison to that in the NC group (P &lt; 0.05). Moreover, pigs fed the OA diet significantly increased the ratio of villus height to crypt depth and upregulated the relative expression of zonula occludens-1 (ZO-1) and Claudin1 gene in the jejunum compared to the NC group (P &lt; 0.05). Interestingly, dietary AGP or OA did not affect the fecal microbiota structure or volatile fatty acid content (P &gt; 0.05). In conclusion, our results suggested that dietary OA supplementation could improve growth performance and antioxidant capacity and protect the intestinal barrier of weaned piglets, therefore, it has the potential to be considered as an alternative to AGP in the pig industry.