bluuebunny/crossref_metadata_2025_split huggingface dataset:
(353) HYPERPROLACTINEMIA AND MALE SEXUAL FUNCTION: FOCUS ON ERECTILE DYSFUNCTION AND SEXUAL DESIRE
Authors: Corona Dr Giovanni , Rastrelli Prof Giulia , Bianchi Dr Nicola , Sparano Dr Clotilde , Sforza Dr Alessandra , Vignozzi Prof Linda , Maggi Prof Mario 
Published: June 2024

Abstract

Objectives
The present study aims to meta-analyze the available studies on the relationship between male sexual function and elevated prolactin (PRL) levels (HPRL).

Methods
An extensive search was conducted using using Medline, Embase, and Cochrane up to August 31st 2022. Published articles reporting the prevalence of HPRL in men with erectile dysfunction (ED) or reduced sexual desire (RSD) and/or the effect of treatment of HPRL on sexual complaints and studies reporting the prevalnce of ED or RSD in men with HPRL were collected.

Results
25 papers were included in the analysis. Of these, 11 investigated the prevalence of HPRL in patients with sexual dysfunction, whereas 15 and 14 investigated the rate of ED and RSD in subjects with HPRL, respectively. The effects of medical or surgical treatment on sexual function in HPRL patients were investigated in 13 studies. Among 10,980 patients, HPRL was detected in 2% of subjects with ED. The prevalence dropped to 0.9[0.6;1.5]% when severe HPRL (PRL&gt;35 ng/ml) was considered. The rate of ED and RSD was investigated in 628 and 616 patients with HPRL and the prevalence was 57[44-69]% and 49[32-66]%, respectively. Higher PRL and lower testosterone at baseline, as well as year of study publication correlated indipendently with the ED rate (B=0.450; p&lt;0.000, −0.158; p&lt;0.001 and −0.237; p&lt;0.0001, respectively). When compared to the baseline, ED was six-fold less frequent after treatment for HPRL, irrespectively of the treatment. When sexual desire was considered, any treatment of the condition resulted in a increased probability of not reporting the symptom at follow-up (OR=59.7 [13.2;269.5]; p&lt;0.0001).

Conclusions
Normalization of PRL levels is able to improve libido. The role of HPRL in ED remains inconclusive. Either HPRL or reduced T levels were independently associated with ED rate. The normalization of PRL levels only partially restored ED whereas sexual desire was greatly improved.

Conflicts of Interest
The authors declare no conflict of interest.
(428) SIS GRAFT BULBAR URETHROPLASTY IS A VIABLE TECHNIQUE: RESULTS COMPARED TO BUCCAL MUCOSA GRAFT URETHROPLASTY AFTER PROPENSITY SCORE MATCHING
Authors: Palminteri Dr Enzo , Toso Dr Stefano , Buffi Prof Nicolò M , Ferrari Dr Giovanni , Nava Dr Luciano , Pane Dr Manuela , di Dio Dr Michele , Preto Dr Mirko , Gobbo Dr Andrea 
Published: June 2024

Abstract

Objectives
Despite some promising reports, the published series on SIS graft urethroplasty (SISU) suffer from short follow-up (FU), inhomogeneous patients, and a lack of a control group. This study aims to report the outcomes of bulbar SISU compared to a buccal mucosa graft urethroplasty (BMU) propensity score-matched cohort.

Methods
From our institutional database of 1132 bulbar urethroplasties, 25 BMU and 25 SISU cases were selected using propensity score matching with nearest-neighbor without replacement. The matching variables were age, stricture length, and history of urethrotomy. Failure was defined as any treatment after urethroplasty, and data were censored at 156mo. Survival analyses were used to analyze treatment failure occurrence.

Results
Matching resulted in a complete correction of bias between the two samples, except for the FU duration, which was slightly longer in the SIS group (125 vs 156mo). At a median FU of 156mo, 8/17 SISU and 4/21 BMU failed. At Kaplan-Meier analysis, the cumulative treatment success probability of BMU and SISU at 156mo was 83.4% and 68%, respectively. At multivariable Cox regression, SIS graft, previous urethrotomy, stricture length, and lower postoperative Qmax (within 2mo after catheter removal) were predictors of failure. Stricture length had a more remarkable effect on treatment success in patients undergoing SISU, with an estimated survival probability from the Cox model lower than 80% in strictures &gt;=3cm. On the contrary, BMU had an estimated success consistently higher than 90%.

Conclusions
This study has the longest FU and the greatest sample of bulbar SISU available. The first postoperative uroflowmetry can identify patients at risk of failure and is a readily available measure useful to tailor FU. The best candidates for SISU are patients with strictures shorter than 3cm, preferably without a history of DVIU. Overall, SISU is a viable technique in selected patients, particularly when BMU is not feasible.

Conflicts of Interest
No conflict of interest to disclose.
(195) DIAGNOSTICS OF CHRONIC PROSTATITIS IN WOMEN OF REPRODUCTIVE AGE
Authors: Grygorenko V , Romashchenko O , Biloholovska V , Melnykov S , Yakovenko L 
Published: June 2024

Abstract

Objectives
Improvement of the diagnostics of chronic prostatitis (CP) in women of reproductive age.

Methods
A gynecological, urological, and sexological examination of 34 women aged from 24 to 34 (31±4.1) with CP lasting between 1 and 4 years was carried out. An ultrasound study of the female prostate gland and paraurethral zone was conducted using the ultrasound diagnostical system APLIO of TOSHIBA expert class brand in the regime of grey scale using the Doppler method.

Results
CP was formed at the background of latent course of an inflammatory disease in pelvic organs and was characterised by vivid symptoms (pain and discomfort during urination, local pain in perineum and the frontal wall of the vagina, heavy secretions from urethra). In 28 (82.4%) patients we found dyspareunia, which was accompanied by alibidemia in 18 (52.9%) of the examined.
During the ultrasound study of female prostate gland, a hypodense lesion having the volume from 0.7 to 1.7 cm with a clear capsule was exposed in the projection of the distal part of urethra in 24 (70.6%) women, in the projection of the proximal part of urethra – in 6 (17.6%) women, and along the urethra – in 4 (11.8%) women. The vascular markings of the paraurethral zone of female prostate gland during the coloured Doppler carding (CDC) were intense. At the same time during the CDC, it was established that the hypodense lesion was nonvascular, with single tiny vessels in the capsule zone.

Conclusions
CP in women of reproductive age was characterised by the explicit clinical recurrent course at the background of latent development of the inflammatory disease of pelvic organs and was formed mostly (70.6%) in patients with the distal location of paraurethral glands, accompanied with the spectre of sexual dysfunctions, where sexual pain should be distinguished as a diagnostical feature of this disease.

Conflicts of Interest
No conflict of interest.
(172) FEMALE SEXUAL FUNCTIONING DURING PREGNANCY: A SINGLE-CENTER SURVEY ON POLISH WOMEN
Authors: Szymanska Edyta , Kisielewski Rafał , Kisielewska Dr Lidia , Tomaszewski Janusz 
Published: June 2024

Abstract

Objectives
Sexual life of pregnant women alters during pregnancy due to the physiological, anatomical and hormonal changes in their body. Therefore, the aim of this study was to evaluate female sexual functioning after becoming pregnant.

Methods
A prospective survey study included 148 pregnant women. An anonymous questionnaire including 60 inquiries concerning the intimate relationship before and during pregnancy was performed. The following statistical test were used: chi-square test of independence, Spearman's rank correlation coefficient and Wilcoxon test. The significance level of p = 0.05 was assumed.

Results
Most of the respondents were between 31 and 40 years old (55%). Majority of them were married (86%). During pregnancy, slightly more than half of women had a moderate need for sexual intercourse (51%), a large percentage of them had a low need (32%), a high need for intercourse was declared by 17% of women. The correlation analysis showed a statistically significant relationship between women's education and the need for sex before pregnancy (p = 0.049). Respondents with higher degrees of education more often felt the need for intercourse before pregnancy. No correlation was found between education and the need for intercourse during pregnancy (p = 0.107). After becoming pregnant, 51% of women had less need for intercourse, 7% more, and 42% the same as before pregnancy, and these differences were statistically significant (p &lt; 0.001). Also, a decreased satisfaction with sexual intercourse was reported during pregnancy (p &lt; 0.001). After getting pregnant, the average number of intercourses decreased in majority (71%) of respondents, and differences in the number of intercourses before and during pregnancy were statistically significant (p &lt; 0.001).

Conclusions
Pregnancy has a significant impact on woman’s sexuality. After becoming pregnant, majority of women declare less need for sexual intercourses and a decreased number of intercourses with less satisfaction.

Conflicts of Interest
No connflict of interests.
(427) UNVEILING UNMET NEEDS: A USER-CENTERED APPROACH TO A DIGITAL INTERVENTION FOR WOMEN AFFECTED BY GYNECOLOGICAL CONDITIONS WITH SEXUAL DISTRESS
Authors: Kosman Eden , Kronthaler Selina M , Franck Lilian R , von der Reidt Antonia , Beier Prof Klaus M , Hatzler Dr Laura 
Published: June 2024

Abstract

Objectives
While many women affected by gynecological conditions (e.g., endometriosis) and sexual distress actively seek medical help, their needs are hardly met within the healthcare system. The primary aim of the study is to develop a user-centered mobile digital intervention tailored to the needs of those affected, employing an iterative approach.

Methods
Phase 1 involved 20 participants in Free List Interviews to identify the unmet needs. During Phase 2, comprising 9 key informants, we conducted Thinking Aloud Interviews to assess the initial prototype's usability and user experience. Furthermore, we have intentions to include an additional 11 participants in the evaluation of an adapted prototype. Phase 3 will entail Focus Group Discussions involving affected individuals, their partners, and healthcare providers to validate pervious findings. Inductive and deductive thematic analysis was and will be used for interview protocol analysis.

Results
The preliminary results of Phase 1 highlight challenges within the healthcare system such as the lack of information for affected individuals, the insufficient knowledge of healthcare providers, and the sense of not being taken seriously. Participants expressed receiving understanding, information about support services, and alternatives for pursuing a fulfilling sexual life as their needs. To address these needs digitally, the focus should be on providing information on sexuality and on support services. Key factors for an effective digital intervention were the inclusion of videos and data privacy, alongside making it accessible through information dissemination in clinical facilities and broad advertisement.

Conclusions
This qualitative study identifies critical challenges within the healthcare system faced by women with gynecological conditions and sexual distress. The study's findings highlight the importance of developing a user-centered digital intervention to address these needs. This research contributes to a more patient-centered approach and aims to improve the quality of care for this underserved population.

Conflicts of Interest
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(415) THE BRIDGE PROJECT: USING CULTURAL INTERVIEW FORMULATION (CFI) TO ADAPT ONLINE INTERVENTIONS FOR CSAM USERS
Authors: Šímová Leona , Klapilová Kateřina , Metenko Prof Jozef , Vaaranen-Valkonen Nina , Ballester-Arnal Prof Rafael , Briken Prof Peer , Rahm Christoffer 
Published: June 2024

Abstract

Objectives
The BRIDGE intervention-research project is exploring the perceptions of anonymous CSAM users on their material using, their need for specialist care, their experiences of seeking care, and also intervenes with time-limited online interventions aimed at motivating change.. This research project aims to gain the cultural perspective of participants, from which intervention strategies can be culturally adapted. Cultural perspective will be surveyed on users from 6 EU countries using the Cultural Formulation Interview (CFI) method.

Methods
This research is implemented using the CFI method, which is part of the DSM-V. The goal is to gain the client's perspective and to uncover the cultural influences that enter into the client's experience and coping. In the field of sexology, the CFI method was used for the first time and its use was tested in advance in a pilot study. Findings specific to the adaptation of the CFI for the sexological domain will also be presented. The analysis of the interviews will be carried out using the qualitative software ATLAS.ti. In each of the participating countries, thematic analysis will identify common and also country-specific themes. The results will be used to adapt the motivational interviewing used in the BRIDGE project interventions and the ReDirection self-help programme.

Results
During the pilot phase, which lasted 2 months, 6 CFIs with English-speaking participants, 1 with German-speaking, 1 with Spanish-speaking and 1 with Swedish-speaking participants were completed. Preliminary results will be presented during the konference.

Conclusions
The results will help to target care delivery designs more effectively. As the darkweb is a global platform, there is a need to have data regarding different cultural backgrounds of its users. The results of the study can also be used by other future intervention programs. Without cultural adaptation of intervention strategies, the best quality intervention effect cannot be achieved.

Conflicts of Interest
Hereby I confirm there is no conflict of interest.
Radial Tully–Fisher relation and the local variance of Hubble parameter
Authors: Haridasu Balakrishna S , Salucci Paolo , Sharma Gauri 
Published: June 2024

ABSTRACT
Utilizing the well-established radial Tully–Fisher (RTF) relation observed in a ‘large’ (843) sample of local galaxies, we report the maximum allowed variance in the Hubble parameter, $H_{0}$. We estimate the total intrinsic scatter in the magnitude of the RTF relation(s) implementing a cosmological model-independent cosmographic expansion. We find that the maximum allowed local ‘radial’ variation in our baseline analysis, using four RTF relations in the galaxy sample is $\Delta H_0/H_0\lesssim 3\ \hbox{per cent}$ at a 95 per cent C.L. significance, which is implied form a constraint of $\Delta H_0/H_0= 0.54^{+1.32}_{-1.37}\ \hbox{per cent}$ estimated at $D_{\rm L}\sim 10\, [{\rm Mpc}]$. Using only one ‘best-constrained’ radial bin, we report a conservative 95 per cent C.L. limit of $\Delta H_0/H_0\lesssim 4\ \hbox{per cent}$. Through our estimate of maximum variation, we propose a novel method to validate several late-time/local modifications put forth to alleviate the $H_0$ tension. We find that within the range of the current galaxy sample redshift distribution $10 \, [{\rm Mpc}] \le D_{\rm L}\le 140\, [{\rm Mpc}]$, it is highly unlikely to obtain a variation of $\Delta H_0/H_0\sim 9\ \hbox{per cent}$, necessary to alleviate the $H_0$-tension. However, we also elaborate on the possible alternative inferences when the innermost radial bin is included in the analysis. Alongside the primary analysis of fitting the individual RTF relations independently, we propose and perform a joint analysis of the RTF relations useful to create a pseudo-standardizable sample of galaxies. We also test for the spatial variation of $H_0$, finding that the current samples’ galaxies distributed only in the Southern hemisphere support the null hypothesis of isotropy within the allowed noise levels.
Phase I and pharmacodynamic study of arsenic trioxide plus radiotherapy in patients with newly diagnosed glioblastoma
Authors: Ryu Samuel , Ye Xiaobu , Olson Jeffrey J , Mikkelsen Tom , Bangiyev Lev , Lesser Glenn J , Batchelor Tracy , Nabors Burt , Desideri Serena , Walbert Tobias , Grossman Stuart A 
Published: June 2024

Abstract

Background
When arsenic trioxide (ATO) was combined with radiation for treatment of transplanted murine gliomas in the brain, tumor response improved with disrupted tumor blood flow and survival was significantly prolonged.

Methods
Total of 31 patients with newly diagnosed glioblastoma were accrued to a multi-institutional, NCI-funded, phase I study to determine the maximum tolerated dose (MTD) of ATO administered with radiation. Secondary objectives were survival and pharmacodynamic changes in perfusion on magnetic resonance imaging (MRI). Patients (unknown MGMT and IDH status) received ATO either once or twice weekly during radiation without concurrent or adjuvant temozolomide.

Results
Median age: 54.9 years, male: 68%, KPS ≥ 90: 77%, debulking surgery: 77%. Treatments were well-tolerated: 81% of patients received all the planned ATO doses. Dose-limiting toxicities included elevated liver function tests, hypokalemia, and edema. The MTD on the weekly schedule was 0.4 mg/kg and on the biweekly was 0.3 mg/kg. The median survival (mOS) for all patients was 17.7 months. Survival on the biweekly schedule (22.8 months) was longer than on the weekly schedule (12.1 months) (P = .039) as was progression-free survival (P = .004). Similarly, cerebral blood flow was significantly reduced in patients treated on the biweekly schedule (P = .007).

Conclusions
ATO with standard radiation is well tolerated in patients with newly diagnosed glioblastoma. Even without temozolomide or adjuvant therapy, the overall survival of all patients (17.7 months) and especially patients who received biweekly ATO (22.8 months) is surprising and accompanied by pharmacodynamic changes on MRI. Further studies of this regimen are warranted.
A tool to assist rheumatologists to engage their lupus patients: the Purple Butterfly
Authors: Huot Sandrine , Fortin Paul R , Godbout Alexandra , Laflamme Cynthia , Pouliot Marc 
Published: June 2024

Abstract

Objective
Translating the highly technical medical jargon of SLE into understandable concepts for patients, their families and individuals without expertise in SLE is a serious challenge. To facilitate communication and enable self-management in SLE, we aimed to create an innovative visual tool, the Purple Butterfly.

Methods
We selected clinically representative criteria for SLE and transposed them as graphical features in an attractive and meaningful visual. We developed a script in R programming language that automatically transposes clinical data into this visualization. We asked SLE patients from a local cohort about the relevance, usefulness and acceptability of this visual tool in an online pilot survey.

Results
The innovative Purple Butterfly features 11 key clinical criteria: age; sex; organ damage; disease activity; comorbidities; use of antimalarials, prednisone, immunosuppressants and biologics; and patient-reported physical and mental health–related quality of life. Each Purple Butterfly provides the health portrait of one SLE patient at one medical visit, and the automatic compilation of the butterflies can illustrate a patient’s clinical journey over time. All survey participants agreed that they would like to use the Purple Butterfly to visualize the course of their SLE over time, and 9 of 10 agreed it should be used during their medical consultations.

Conclusion
The Purple Butterfly nurtures effective doctor–patient communication by providing concise visual summaries of lupus patients’ health conditions. We believe the Purple Butterfly has the potential to empower patients to take charge of their condition, enhance healthcare coordination and raise awareness about SLE.
Cutting-edge care: unleashing artificial intelligence's potential in gynecologic surgery
Authors: Leaf Marie-Claire , Musselman Kelsey , Wang Karen C. 
Published: June 2024

Purpose of review
Artificial intelligence (AI) is now integrated in our daily life. It has also been incorporated in medicine with algorithms to diagnose, recommend treatment options, and estimate prognosis.

Recent findings
AI in surgery differs from virtual AI used for clinical application. Physical AI in the form of computer vision and augmented reality is used to improve surgeon's skills, performance, and patient outcomes.

Summary
Several applications of AI and augmented reality are utilized in gynecologic surgery. AI's potential use can be found in all phases of surgery: preoperatively, intra-operatively, and postoperatively. Its current benefits are for improving accuracy, surgeon's precision, and reducing complications.
The Long-Term Benefit of Exercise With and Without Manual Therapy for Mild Chronic Obstructive Pulmonary Disease
Authors: Engel Roger Mark , Gonski Peter , Vemulpad Subramanyam , Graham Petra L. 
Published: June 2024

Purpose:
Chronic obstructive pulmonary disease (COPD) is characterized by decreasing exercise capacity and deteriorating quality of life (QoL). Recent evidence indicates that combining exercise with manual therapy (MT) delivers greater improvements in exercise capacity than exercise alone in moderate COPD. The aim of this study was to investigate whether this combination delivers similar results in mild COPD.

Methods:
A total of 71 participants aged 50-65 yr with mild COPD were randomly allocated to two groups: exercise only (Ex) or MT plus exercise (MT + Ex). Both groups received 16 wk of exercise with the MT + Ex group also receiving 8 MT sessions. Lung function (forced vital capacity [FVC] and forced expiratory volume in the 1st sec [FEV1]), exercise capacity (6-min walk test [6MWT]), and QoL (St George’s Respiratory Questionnaire [SGRQ] and Hospital Anxiety and Depression Scale [HADS]) were measured at baseline, 4, 8, 16, 24, 32, and 48 wk.

Results:
Although there was no difference in the mean effect over time between groups for lung function (FEV1, P= .97; FVC, P= .98), exercise capacity (6MWT, P= .98), and QoL (SGRQ, P= .41; HADS anxiety, P= .52; and HADS depression, P= .06), there were clinically meaningful improvements at 48 wk for 6MWT (30 m; 95% CI, 10-51 m; P< .001), SGRQ (6.3 units; 95% CI, 2.5-10.0; P< .001), and HADS anxiety (1.5 units; 95% CI, 0.3-2.8 units; P= .006) across the entire cohort.

Conclusions:
While adding MT to Ex did not produce any additional benefits, exercise alone did deliver sustained modest improvements in exercise capacity and QoL in mild COPD.