bluuebunny/crossref_metadata_2025_split huggingface dataset:
Redesigning the message logging model for high performance
Authors: Bouteiller Aurelien , Bosilca George , Dongarra Jack 
Published: June 2010

AbstractOver the past decade the number of processors used in high performance computing has increased to hundreds of thousands. As a direct consequence, and while the computational power follows the trend, the mean time between failures (MTBF) has suffered and is now being counted in hours. In order to circumvent this limitation, a number of fault‐tolerant algorithms as well as execution environments have been developed using the message passing paradigm. Among them, message logging has been proved to achieve a better overall performance when the MTBF is low, mainly due to a faster failure recovery. However, message logging suffers from a high overhead when no failure occurs. Therefore, in this paper we discuss a refinement of the message logging model intended to improve the failure‐free message logging performance. The proposed approach simultaneously removes useless memory copies and reduces the number of logged events. We present the implementation of a pessimistic message logging protocol in Open MPI and compare it with the previous reference implementation MPICH‐V2. The results outline a several order of magnitude improvement on the performance and a zero overhead for most messages. Published in 2010 by John Wiley & Sons, Ltd.
High‐Surface‐Area Carbon Molecular Sieves for Selective CO2 Adsorption
Authors: Wahby Anass , Ramos‐Fernández José M. , Martínez‐Escandell Manuel , Sepúlveda‐Escribano Antonio , Silvestre‐Albero Joaquín , Rodríguez‐Reinoso Francisco 
Published: June 2010

AbstractA series of carbon molecular sieves (CMSs) has been prepared, either as powders or monoliths, from petroleum pitch using potassium hydroxide as the activating agent. The CMS monoliths are prepared without the use of a binder based on the self‐sintering ability of the mesophase pitch. Characterization results show that these CMSs combine a large apparent surface area (up to ca. 3100 m2 g−1) together with a well‐developed narrow microporosity (Vn up to ca. 1.4 cm3 g−1). The materials exhibit high adsorption capacities for CO2 at 1 bar and 273 K (up to ca. 380 mg CO2 g sorbent−1). To our knowledge, this is the best result obtained for CO2 adsorption using carbon‐based materials. Furthermore, although the CO2 adsorption capacity for activated carbons has usually been considered lower than that of zeolites, the reported values exceed the total amount adsorbed on traditional 13X and 5A zeolites (ca. 230 mg and 180 mg CO2 g sorbent−1, respectively), under identical experimental conditions. Additionally, the narrow pore openings found in the CMS samples (ca. 0.4 nm) allows for the selective adsorption of CO2 from molecules of similar dimensions (e.g., CH4 and N2).
Cobalt(II) Coordination Polymers Containing trans‐1,2‐Bis(4‐pyridyl)ethene and Their Magnetic Properties
Authors: Peedikakkal Abdul Malik Puthan , Song Yu‐Mei , Xiong Ren‐Gen , Gao Song , Vittal Jagadese J. 
Published: June 2010

AbstractReaction of the CoII ion and the bpe [trans‐1,2‐bis(4‐pyridyl)ethene] ligand in the presence of the CH3CO2–, CF3CO2–, C6H5CO2– and NO3– anions affords six coordinationpolymers, namely [Co2(μ‐bpe)2(μ‐O2CCH3)2(O2CCH3)2]·H2O (1), [Co2(μ‐bpe)2(μ‐O2CCF3)2(O2CCH3)2] (2), [Co(μ‐bpe)2(O2CCF3)2] (3), [Co(μ‐bpe)(O2CC6H5)2(HO{O}CC6H5)2] (4), [Co(μ‐bpe)(O2CC6H5)2(CH3OH)2] (5) and [Co2(μ‐bpe)3(NO3)3(CH3OH)](NO3) (6). All the compounds have been characterized by X‐ray crystallography, IR spectroscopy and thermogravimetry. Variable‐temperature magnetic measurements were also performed on 3 and 6. Compounds 1 and 2 form 1D molecular ladder coordination polymers bridged by acetate ligands. Replacing the acetate ligands completely by trifluoroacetate ligands produced interpenetrated square‐grid sheets in 3. Replacing acetate and trifluoroacetate ligands by benzoate ligands resulted in two 1D coordination polymers, 4 and 5, having zigzag and linear structures, respectively. When the nitrate anion was used, a 3D network, 6, was afforded with inclined interpenetration of a 1D molecular ladder structure with threefold polycatenation. The variation of anions, reaction conditions and the ratio of reactants profoundly affect the final topological structure of the coordination polymers synthesized. The trifluoroacetate and nitrate anions influence the topology and the degree of interpenetration in the coordination polymers 3 and 6, respectively.
Health care utilization, cost burden and coping strategies by disability status: an analysis of the Viet Nam National Health Survey
Authors: Palmer Michael , Nguyen Thuy , Neeman Teresa , Berry Helen , Hull Terence , Harley David 
Published: June 2010

SUMMARYThere is a need for nationally representative information on the affordability of health care by disability status to assist in the design of equitable health systems in developing countries. Using the Viet Nam National Health Survey (2001–2002), this paper analyses health care utilization, cost burden and coping strategies for people with disabilities versus the population at large. The results clearly show that the disabled population are more prone to hospitalization, and spend more on inpatient stays and pharmaceuticals. Households with disabled members are at greater risk of catastrophic health expenditures and debt financing, posing a serious threat to economic welfare. Copyright © 2010 John Wiley & Sons, Ltd.
Deletion of liver‐cell surface membrane components from aminoazo‐dye‐induced rat hepatomas
Authors: Baldwin R. W. , Glaves Dorothy 
Published: June 2010

AbstractDeletion of liver‐specific cell‐surface‐associated antigens from aminoazodyeinduced rat hepatomas was demonstrated by immunofluorescence techniques. Each of the hepatomas studied was found to lack a characteristic individual normal liver antigen. This parallels the concomitant expression of new hepatoma‐specific antigens which are also characteristic for each of these tumours. These findings suggest that neoplastic transformation by aminoazo dyes may result in the replacement of normal liver components at the cell surface by tumour‐specific antigens.
In vitro studies on cell‐mediated immunity following surgery in mice sensitized to syngeneic mammary tumors
Authors: Heppner G. H. 
Published: June 2010

AbstractThe effect of surgical removal of a tumor on cellular immunity, and on serumblocking activity of cellular immunity, was studied in mice sensitized by transplantation to syngeneic mammary tumors. Immunity was assayed in vitro by colony inhibition tests. Cell‐mediated immunity, tested 10‐15 days after surgery, was enhanced in mice from which tumors had either been completely excised, or left intact after sham surgery, as compared to mice which had experienced no surgical treatment. Blocking activity was depressed by complete removal of the tumor, but not by sham surgery alone. In mice which had complete removal, blocking activity decreased with time following surgery, being lower 10‐15 days than 1‐5 days after treatment.
Effect of L‐thioproline on the progression and events of the cell cycle of hela cells
Authors: Cañero Rafael García , López‐Alarcón Luisa , Veloso Juan José , Guijarro María Del Carmen 
Published: June 2010

AbstractL‐thioproline (thiazolidine‐4‐carboxylic acid, L‐Tp) reduces DNA synthesis in cultured HeLa cells by about 50% when added to synchronized cultures at the beginning of G1 phase. This inhibition is not observed when the drug is added at mid‐S, in G2 or in M. L‐Tp almost annuls the burst in 22Na uptake occurring at the beginning of G1 and is as potent an inhibitor as amiloride. It is also able to delay the apparition of the early S‐specific cAMP peak and to elevate its intracellular concentration. These results indicate that L‐Tp could decrease tumor cell growth by acting at the G1‐S boundary.
Oral contraceptives and breast cancer: A cooperative Italian study
Authors: La Vecchia Carlo , Negri Eva , Franceschi Silvia , Talamini Renato , Amadori Dino , Filiberti Rosa , Conti Ettore , Montella Maurizio , Veronesi Andrea , Parazzjni Fabio , Ferraroni Monica , Decarli Adriano 
Published: June 2010

AbstractThe relationship between oral contraceptives (OC) and breast‐cancer risk was analysed using data from a case‐control study conducted between June 1991 and February 1994 in 6 Italian centres on 1,991 patients below age 65 with histologically confirmed incident breast cancer and 1,899 controls admitted to hospital for a wide range of acute, non‐neoplastic, nonhormone‐related diseases. “Ever OC use” was reported by 18% of cases versus 14% of controls, corresponding to a multivariate odds ratio (OR) of 1. 1 (95% confidence interval, CI 0.9 to 1.4). The ORs were 1.3 for use lasting < 1 year, 1. 1 for 1 to 4 years, 0.9 for 5 to 8 years, and 1.2 for over 8 years. With reference to age at first use, there was some indication that the OR was elevated in women who had started use before age 30, but not in those starting at a later age. With reference to time since last OC use, the OR was above unity for women who had stopped for less than 10 years (1.6 for 1 to 4 years; 1.7 for 5 to 9 years), but the OR declined to unity for women who had stopped OC use for 10 years or longer. The OR for women who had stopped OC use for less than 10 years was consistently elevated across strata of selected covariates, and was directly related to the duration of use (OR 1.3 for < 5 years, 1.7, for ≥5 years). In contrast, the OR was 0.6, for use lasting ≥ 5 years in women who had stopped for 10 years or more. The elevated OR for women who had recently stopped OC use, together with the absence of association (or the suggestion of some protection) for those who had stopped for 10 years or more is consistent with the pattern of breast‐cancer risk observed after a full‐term pregnancy, and provides important reassurance on a public health level on the long‐term impact of OCs on breast carcinogenesis. © 1995 Wiley‐Liss, Inc.
Tumor resistance to oxidative stress: Association with ras oncogene expression and reversal by lovastatin, an inhibitor of p21ras isoprenylation
Authors: Miller Alexandra C. , Samid Dvorit 
Published: June 2010

AbstractThe ras oncogene family has been implicated in tumor resistance to ionizing radiotherapy. Using the gene‐transfer model, we show here that ras expression may also affect cell responses to chemical inducers of oxidative stress. Studies involving human osteosarcoma subclones, which vary in their levels of EJras expression, revealed a tight correlation between the amounts of ras‐encoded mRNA and p21 produced, and the degree of resistance to doxorubicin or hydrogen peroxide. Differences in response could not be explained by increased activity of anti‐oxidant enzymes such as superoxide dismutase, glutathione reductase, glutathione S‐transferase or glutathione peroxidase. Moreover, there were no significant differences in glutathione levels. Although the resistant cells had elevated levels of gamma‐glutamyl‐transferase mRNA indicative of an increased rate of glutathione turnover, this elevation was not specific for ras‐transfected cell lines. Lovastatin, an inhibitor of protein isoprenylation critical for p21 ras membrane association and function, restored the sensitivity of ras‐transformed cells to doxorubicin and hydrogen peroxide. The data indicate that pharmacological agents affecting ras expression may enhance responses of some human tumors to free‐radical‐mediated chemotherapies. © 1995 Wiley‐Liss, Inc.
Human high molecular weight‐melanoma associated antigen mimicry by mouse anti‐idiotypic MAb MK2‐23. Immunohistochemical analysis of the reactivity of anti‐anti‐idiotypic MAb with surgically removed melanoma lesions
Authors: Kageshita Toshiro , Hirai Shunji , Ono Tomomichi , Ferrone Soldano 
Published: June 2010

AbstractThe mouse anti‐id MAb MK2‐23 bears the internal image of the antigenic determinant defined by anti‐HMW‐MAA MAb 763.74. Active specific immunotherapy with anti‐id MAb MK2‐23 is associated with a statistically significant prolongation of survival in patients with malignant melanoma. Characterization of the immune response elicited by anti‐id MAb MK2‐23 may contribute to our understanding of the mechanisms underlying the apparent beneficial clinical effects of active specific immunotherapy with anti‐id MAb MK2‐23. Therefore, 8 HMW‐MAA binding anti‐anti‐id MAbs elicited with MAb MK2‐23 were characterized in their reactivity with a large panel of surgically removed benign and malignant tumors and of normal tissues. The 8 anti‐anti‐id MAbs displayed subtle differences in their immunoperoxidase staining of both benign and malignant lesions and of normal tissues. The diversity in the fine specificity of the 8 anti‐anti‐id MAbs is likely to reflect the few somatic mutations which occur in the amino‐acid sequence of the variable regions of their heavy and light chains in the course of the immune response to MAb MK2‐23. The reactivity patterns of the 8 anti‐anti‐id MAbs with the tissue substrates are similar, although not superimposable upon that of anti‐HMW‐MAA MAb 763.74 elicited with melanoma cells. This difference may reflect the imperfect mimicry by anti‐id MAb MK2‐23 of the antigenic determinant defined by anti‐HMW‐MAA MAb 763.74. © 1995 Wiley‐Liss, Inc.
Multiple births, sex of children and subsequent breast‐cancer risk for the mothers: A prospective study in Norway
Authors: Albrktsen Grethe , Heuch Ivar , Kvåle Gunnar 
Published: June 2010

AbstractEndocrinological changes occurring during pregnancy may influence the subsequent cancer risk of the mother. Further, the endocrinological milieu may differ according to different birth characteristics. In the present study possible relations between multiple births, sex of children and breast‐cancer risk were examined in a population‐based, prospective study of 802,269 parous Norwegian women aged 20–56 years. A total of 4,782 women were diagnosed with breast cancer during follow‐up. Of these, 97 had ever experienced a multiple birth. We found a slightly lower risk of breast cancer among women ever having had a multiple birth than among women with singletons only (IRR = 0.89, 95% CI = 0.73–1.09). The reduction in risk was mainly observed among women with a multiple last birth. Further, the reduction in risk seemed to diminish with increasing parity, and among women with 4 or more full‐term pregnancies, ever having had a multiple birth was associated with an elevated risk (IRR = 1.48, 95% CI = 0.97–2.25). The sex of the first or last child did not affect the subsequent breast‐cancer risk. Further, we found no associations with the sex distribution among all children or in multiple births, despite a tendency toward a reduced risk among women with several daughters only. © 1995 Wiley‐Liss, Inc.
International renal‐cell cancer study. III. Role of weight, height, physical activity, and use of amphetamines
Authors: Mellemgaard Anders , Linoblad Per , Schlehofer Brigitte , Bergström Rcinhold , Mandel Jack S. , McCredie Margaret , McLaughlin Joseph K. , Niwa Shelley , Odaka Nancy , Pommer Wolfgang , Olsen Jorgen H. 
Published: June 2010

AbstractAlthough numerous studies have identified obesity or high relative weight as a risk factor for renal‐cell cancer in women, the degree to which this effect is present in men remains unclear. A multicenter population‐based case‐control study concerning incident cases of histologically verified renal‐cell cancer (n = 1,732) and age‐ and sex‐matched controls (n = 2,309) was conducted in Australia, Denmark, Germany (2 centers), Sweden and the United States. Relative weight was estimated by the body mass index, and the association between this factor and other factors, such as height, physical activity and use of amphetamines, was measured by the relative risk estimated in logistic regression models. Body mass index was found to be a risk factor among women and, to a lesser extent, among men. A 3‐fold increased risk (RR = 3.6, 95% CI = 2.3–5.7) was observed for women with a relative weight in the top 5% compared with those in the lowest quartile. Rate of weight change (estimated as weight change per annum in kilograms) appeared to be an independent risk factor among women but not among men. Physical activity and height were unrelated to risk of renal‐cell cancer regardless of level of BMI, while use of amphetamines was associated with an increased risk among men, although no dose or duration effect was seen. Our findings verify the link between high relative weight and risk of renal‐cell cancer, particularly among women. The mechanism that underlies this association is, however, still unclear, although the rate of weight change may play a role. © 1995 Wiley‐Liss, Inc.
Antibodies against linear and conformational epitopes of human papillomavirus type 16 that independently associate with incident cervical cancer
Authors: Dillner Joakim , Wiklund Fredrik , Lenner Per , Eklund Carina , Fredriksson‐Shanazarian Vanoohi , Schiller John T. , Hibma Merilyn , Hallmans Göran , Stendahl Ulf 
Published: June 2010

AbstractIn a seroepidemiological study of incident cervical cancer, 94 cases and 188 population‐based controls were used to evaluate the disease‐association of IgG and IgA antibody responses against 6 human papillomavirus (HPV) type‐16 antigens. Nine of the tested antibody responses were positively associated with cervical cancer, with odds ratios (ORs) ranging from 2.5 to 15.0. The antibody responses most strongly associated with cervical cancer were IgA against E6:10, an epitope derived from the carboxyterminal part of the HPV16 E6 [OR = 15.0, confidence intervals (CI) = 5.9–48.6], IgG against HPV16 virus‐like particles (OR = 9.5, CI = 3.9‐28.0) and IgG against the EI:19 epitope in the middle part of the EI protein of HPV16 (OR = 7.7, CI = 3.9–16.5). When the 3 serological assays that showed the strongest association with cervical cancer were combined, positivity for 2 assays was found among 52% of cases at an OR of 29.9. We conclude that antibody responses to several linear and conformational HPV epitopes are independently associated with cervical cancer and that combined analysis of several HPV antibody responses can result in better predictive values for HPV‐associated cancer. © 1995 Wiley‐Liss, Inc.
Photosensitizing efficacy of MTHPC‐PDT compared to Photofrin‐PDT in the RIF1 mouse tumour and normal skin
Authors: van Geel Ingrid P. J. , Oppelaar Hugo , Oussoren Yvonne G. , Van Valk Martin A. Der , Stewart Fiona A. 
Published: June 2010

AbstractThe new photosensitizer, meso‐tetrahydroxyphenylchlorin (mTPHC) was compared with Photofrin in the murine RIF1 tumour and in normal mouse skin. A range of mTHPC or Photofrin doses were given at intervals of 1 hr to 7 days before illumination. mTHPC‐PDT resulted in much higher tumour phototoxicity with longer regrowth delays and more cures. The RIFI tumour could be effectively treated with 30 J cm−1 (interstitial illumination) at 1 day after mTHPC, whereas 4 to 13 times higher light doses were required with Photofrin for an equivalent anti‐tumour effect. High doses of mTHPC also caused more skin phototoxicity (superficial illumination) than Photofrin for the 1‐day illumination interval. Evaluating both tumour and normal skin photosensitization, the largest therapeutic gain factor (TGF) for mTHPC‐PDT was achieved with a low drug dose (0.15 mg kg−1) at 1 day before illumination (TGF = 5.6, relative to Photofrin PDT). The duration of cutaneous photosensitivity for mTHPC was shorter than for Photofrin. The light dose required to produce a desquamation response in 50% of the animals increased more than 20‐fold over the period 1 to 7 days after high doses of mTHPC, whereas this light dose only increased by a factor of 2 from 1 to 7 days after Photofrin. The large therapeutic gains seen for mTHPC‐mediated PDT compared to Photofrin, plus the rapid fading of skin photosensitization, suggest that mTHPC is a potent photosensitizer suitable for clinical testing. © 1995 Wiley‐Liss, Inc.
Altered transcription control is responsible for the increased level of proliferation‐associated P120 in rapidly growing breast carcinoma
Authors: Fonagy Anna , Swiderski Carol , Freeman James W. 
Published: June 2010

AbstractTranscriptional and post‐transcriptional regulation of proliferation‐associated nucleolar P120 protein expression was examined in 1 normal and 5 malignant breast cell lines. The 6 breast cell lines could be placed into 3 categories on the basis of in vitro growth rate. BT549 and HBL100 grew rapidly; MCF‐7/6, MCF‐7/AZ and Hs578T grew at a moderate rate; and Hs578N normal epithelia grew slowly. There was a significant correlation between the growth rate, measured by percentage of S‐phase fraction of cells or doubling time of cell numbers and the steady‐state levels of either P120 protein or P120 mRNA. Next, the mechanisms responsible for the increased level of P120 expression, which is associated with rapidly growing breast carcinoma, were examined. The stability of P120 mRNA was measured by densitometry of quantitative Northern blots of mRNAs from cells treated with actinomycin D. Before the expected decay, a sharp increase in P120 mRNA level was detected shortly after inhibiting the overall RNA or protein synthesis. The calculated half‐life of P120 mRNA was very similar (1.8 ± 0.2 hr) in all 6 cell lines examined. The transcription rate of the P120 gene was determined by densitometric analysis of quantitative nuclear run‐off assays. A significant positive correlation was found between the transcription rate of the P120 gene and the steady‐state levels of either P120 protein or P120 mRNA. Our conclusion is that the expression of P120 protein is transcriptionally regulated in these breast cells. Therefore, the characteristically high level of P120 protein and mRNA found in most breast carcinomas is due to the altered transcription rate of the P120 gene in transformed cells. © 1995 Wiley‐Liss, Inc.
Inhibition of TPA and 12(S)‐HETE‐stimulated tumor cell adhesion by prostacyclin and its stable analogs: Rationale for their antimetastatic effects
Authors: Tang D. G. , Grossi I. M. , Tang K. Q. , Diglio C. A. , Honn K. V. 
Published: June 2010

AbstractWe have investigated the regulatory role of PGI2 and its stable analogs, i.e., iloprost and cicaprost, on 12(S)‐HETE‐ and TPA‐enhanced tumor cell integrin expression and adhesion. Walker 256 carcinosarcoma cells express αllb β3 integrin receptors, which mediate their adhesion to endothelium, subendothe‐lial matrix and fibronectin. Adhesion is enhanced by treatment with exogenous 12(S)‐HETE but not 12(R)‐HETE or other lipoxygenase‐derived hydroxy fatty acids, as well as by TPA. Both 12(S)‐HETE and TPA enhanced αllb β3 expression on W256 cells. PGI2 iloprost and cicaprost inhibited both 12(S)‐HETE‐ and TPA‐enhanced adhesion to endothelium and suben‐dothelial matrix as well as αllb β3 expression on W256 cells. The mechanism responsible for the effect of PGI2 was explored. Prostacyclin treatment of W256 cells resulted in an enhanced production of cAMP in a time‐ and dose‐dependent manner. Pre‐treatment of tumor cells with increasing concentrations of adenosine resulted in a dose‐dependent decrease in the PGI2 effect on TPA or 12(S)‐HETE‐enhanced adhesion, suggesting that the PGI2 effect is mediated through PKA. Dibutyryl cAMP also blocked the 12(S)‐HETE‐ or TPA‐enhanced adhesion, and adenosine pre‐treatment did not result in an inhibition of the dibutyryl cAMP effect. Collectively, our results suggest that the cyclooxygenase metabolite PGI2 can antagonize the lipoxygenase metabolite 12(S)‐HETE‐ and TPA‐enhanced αllb β3 expression and tumor cell adhesion via activation of adenylate cyclase and elevation of intracellular levels of cAMP. © 1995 Wiley‐Liss, Inc.