bluuebunny/crossref_metadata_2025_split huggingface dataset:
MYT1L is a candidate gene for intellectual disability in patients with 2p25.3 (2pter) deletions
Authors: Stevens Servi J.C. , van Ravenswaaij‐Arts Conny M.A. , Janssen Jannie W.H. , Klein Wassink‐Ruiter Jolien S. , van Essen Anthonie J. , Dijkhuizen Trijnie , van Rheenen Jeroen , Heuts‐Vijgen Regina , Stegmann Alexander P.A. , Smeets Eric E.J.G.L. , Engelen John J.M. 
Published: October 2011

AbstractA partial deletion of chromosome band 2p25.3 (2pter) is a rarely described cytogenetic aberration in patients with intellectual disability (ID). Using microarrays we identified deletions of 2p25.3, sized 0.37–3.13 Mb, in three adult siblings and three unrelated patients. All patients had ID, obesity or overweight and/or a square‐shaped stature without overt facial dysmorphic features. Combining our data with phenotypic and genotypic data of three patients from the literature we defined the minimal region of overlap which contained one gene, i.e., MYT1L. MYT1L is highly transcribed in the mouse embryonic brain where its expression is restricted to postmitotic differentiating neurons. In mouse‐induced pluripotent stem cell (iPS) models, MYT1L is essential for inducing functional mature neurons. These resemble excitatory cortical neurons of the forebrain, suggesting a role for MYT1L in development of cognitive functions. Furthermore, MYT1L can directly convert human fibroblasts into functional neurons in conjunction with other transcription factors. MYT1L duplication was previously reported in schizophrenia, indicating that the gene is dosage‐sensitive and that shared neurodevelopmental pathways may be affected in ID and schizophrenia. Finally, deletion of MYT1, another member of the Myelin Transcription Factor family involved in neurogenesis and highly similar to MYT1L, was recently described in ID as well. The identification of MYT1L as candidate gene for ID justifies further molecular studies aimed at detecting mutations and for mechanistic studies on its role in neuron development and on neuropathogenic effects of haploinsufficiency. © 2011 Wiley Periodicals, Inc.
The genetics of antipsychotic induced tremors: A genome‐wide pathway analysis on the STEP‐BD SCP sample
Authors: Drago Antonio , Crisafulli Concetta , Serretti Alessandro 
Published: October 2011

AbstractExtrapyramidal symptoms (EPS) are associated with antipsychotic treatment. The exact definition of the genetic variants that influence the antipsychotic induced EPS would dramatically increase the quality of antipsychotic prescriptions. We investigated this issue in a subsample of the Systematic Treatment Enhancement Program for Bipolar Disorder (STEP‐BD). Four hundred nine manic patients were treated with antipsychotics and had complete clinical and genetic data. Outcome was an item of the Clinical Monitoring Form which scored tremors from 0 to 4 at each clinical visit. Visits were scheduled according to clinical issues, based on a naturalistic approach. A genomic inflation factor of 1.017 resulted after genetic quality control. Single SNPs GWAS (Plink) and molecular pathway GWAS were conducted (SNP ratio test, KEGG depository). No single SNP reached GWAS significance level of association. Molecular pathways related to cell survival events and lipid synthesis were significantly associated with antipsychotic induced EPS (P = 0.0009 for Hsa04512, Hsa01031, Hsa00230, Hsa04510, Hsa03320, Hsa04930, and Hsa04115; P = 0.0019 for Hsa04020 and Hsa00561). This finding was consistent with previous GWAS studies. © 2011 Wiley Periodicals, Inc.
Silicone‐based hydrogels prepared by interpenetrating polymer network synthesis: Swelling properties and confinements effects on the formation kinetics
Authors: Alizadeh Mina , Abbasi Farhang , Farahi Maryam , Jalili Kiyumars 
Published: October 2011

AbstractIn this work, interpenetrating polymer networks (IPNs) of polydimethylsiloxane (PDMS) and poly(acrylic acid) or poly(2‐hydroxyethyl methacrylate) (PHEMA) have been synthesized employing a sequential method. Monomeric AAc or HEMA was introduced into the PDMS network by swelling the polymer in solutions of monomer. The polymerization of monomers was then conducted in the swollen network. The swelling properties of the IPNs were investigated by varying the monomer concentrations in the polymerization and more swelling was observed with low monomer concentrations due to the prevalence of cyclization reactions. Multi‐step polymerization used to achieve IPNs with high hydrogel contents, did not improve their water uptake. The kinetics of acrylic acid polymerization was studied under various conditions. Specifically, in the presence of confinement effects imposed by the PDMS network a considerable drop in the rate of reaction was observed. The cross‐linking density of the PDMS network was also studied how to affect the reaction rate. © 2011 Wiley Periodicals, Inc. J Appl Polym Sci, 2012
Synthesis, Molecular Modelling and Biological Evaluation of 4‐Amino‐2(1H)‐quinazolinone and 2,4(1H,3H)‐Quinazolidone Derivatives as Antitumor Agents
Authors: Richter Stephanie , Gioffreda Barbara 
Published: October 2011

AbstractA series of 6‐benzoyl‐, 6‐arylthio‐ and 6‐arylsulfonyl‐4‐amino‐2(1H)‐quinazolinones and ‐2,4(1H,3H)‐quinazolinediones were prepared. They were evaluated in vitro for their cytotoxicity against the NCI‐60 cancer cell lines.
Synthesis and Biological Evaluation of Antifungal Activities of Novel 1,2‐trans Glycosphingolipids
Authors: Ding Ning , Zhang Wei , Lv Guokai , Li Yingxia 
Published: October 2011

AbstractThe synthesis and in‐vitro biological evaluation of antifungal activities of a series of 1,2‐trans glycosphingolipids (GSL) against Candida albicans, Candida parapsilosis, and Candida tropicalis were described. The preliminary study indicated that the sort of sugar moiety of GSLs affected their antifungal activities and selectivities towards the three Candida species, and the permeability might not be the sole parameter affecting their antifungal properties as presumed before, which would bring new clues to understand the antifungal profile for these types of compounds.
Synthesis and Biological Activity of Ethyl 2‐(substituted benzylthio)‐4‐(3′‐(ethoxycarbonyl)biphenyl‐4‐yl)‐6‐methyl‐1,4‐dihydropyrimidine‐5‐carboxylate Derivatives
Authors: Maddila Suresh , Jonnalagadda Sreekantha B. 
Published: October 2011

AbstractIn the present study, a new series of ethyl 2‐(substituted benzylthio)‐4‐(3′‐(ethoxycarbonyl)‐biphenyl‐4‐yl)‐6‐methyl‐1,4‐dihydropyrimidine‐5‐carboxylate derivatives was synthesized. The newly synthesized compounds were characterized by1H‐NMR, mass and C, H, N analyses. All newly synthesized compounds were screened for their antibacterial (Escherichia coli,Staphylococcus aureus,Pseudomonas aeruginosa,Streptococcus pyogenesandKlebsiella pneumoniae) and antifungal (Aspergillus flavus,Aspergillus fumigatus,Candida albicans,Penicillium marneffeiandTrichophyton mentagrophytes) activity. The results revealed that all synthesized compounds have a significant biological activity against the tested microorganisms. Compounds8a,8b,8c,8e,8f,8i, and8jexhibited good antimicrobial activity.
Cardiac tamponade as a complication of laparoscopic hiatal hernia repair: Case report and literature review
Authors: Paz Yehuda Edo , Vazquez Jesus , Bessler Marc 
Published: October 2011

AbstractWe report the case of a 61‐year old female with history of gastroesophageal reflux disease and hiatal hernia who developed hemopericardium and tamponade one day after laparoscopic hiatal hernia repair and Toupe fundoplication. The patient underwent emergent pericardiocentesis and subsequent surgical pericardial window. During surgery, a tack that had been used to secure mesh to the inferior aspect of the diaphragm was found to have penetrated the pericardium near the right ventricle. The offending foreign body was trimmed and reduced into the abdomen, and the patient recovered without further complication. A review of the literature reveals that, although rare, tamponade following diaphragmatic hernia repair and fundoplication surgery often results in fatal outcome. Tamponade must be considered in any patient who develops signs of hemodynamic instability following diaphragmatic hernia repair or fundoplication surgery, as rapid diagnosis and definitive intervention can decrease fatality from such an injury. © 2011 Wiley‐Liss, Inc.
Aryl–Aryl Bond Formation by the Fluoride‐Free Cross‐Coupling of Aryldisiloxanes with Aryl Bromides
Authors: Boehner Christine M. , Frye Elizabeth C. , O'Connell Kieron M. G. , Galloway Warren R. J. D. , Sore Hannah F. , Dominguez Patricia Garcia , Norton David , Hulcoop David G. , Owen Martin , Turner Gillian , Crawford Claire , Horsley Helen , Spring David R. 
Published: October 2011

AbstractThe prevalence of the biaryl structural motif in biologically interesting and synthetically important molecules has inspired considerable interest in the development of methods for aryl–aryl bond formation. Herein we describe a novel strategy for this process involving the fluoride‐free, palladium‐catalysed cross‐coupling of readily accessible aryldisiloxanes and aryl bromides. Using a statistical‐based optimisation process, preparatively useful reaction conditions were formulated to allow the cross‐coupling of a wide range of different substrates. This methodology represents an attractive, cost‐efficient, flexible and robust alternative to the traditional transition‐metal‐catalysed routes typically used to generate molecules containing the privileged biaryl scaffold.
Novel Production Technology to Automate the Generation of Hanging Drops for Mass Production of Organotypic Microtissues
Authors: Drewitz Maren , Caminada Daniel , Moritz Wolfgang , Lichtenberg Jan , Kasper Cornelia , Kelm Jens M. 
Published: October 2011

AbstractFür eine natürliche Funktionalität von Zellkulturen z. B. bei der Entwicklung von Biopharmazeutika ist die 3‐dimensionale (3D) Umgebung notwendig. Daher werden verstärkt Technologien entwickelt, um Zellen in einer natürlicheren, gewebe‐ähnlichen Umgebung zu kultivieren. Ein entscheidender Schritt zur industriellen Anwendung von organotypischen 3D‐Kulturen ist die Entwicklung von automatisierbaren Technologien, die Hochdurchsatz‐Produktionsverfahren ermöglichen. Eine neue Technologie zur Generierung von Mikrogeweben und deren Implementierung in einen automatisierten Produktionsprozess wird vorgestellt. Sie ermöglicht die Generierung einer hängenden Tropfenkultur in analoger Weise zu 2D‐Multi‐Well‐Platten. Anhand der Produktion von Dickdarm‐Tumor‐Mikrogeweben und primärem Rattenleber‐Mikrogewebe wird gezeigt, dass der Produktionsprozess mit gleicher Genauigkeit geführt werden kann wie Standardprozesse.
Energy Storage by CO2 Methanization and Energy Carrying Compounds: A Thermodynamic Comparison
Authors: Müller Benjamin , Müller Karsten , Teichmann Daniel , Arlt Wolfgang 
Published: October 2011

AbstractDie Umstellung fossil dominierter Energiesysteme auf eine Versorgung mit hohem Anteil erneuerbarer Energien macht einen massiven Ausbau der Speichersysteme erforderlich. Gängige Technologien wie Pumpspeicherkraftwerke oder Druckluftspeicher sind in ihrer Kapazität beschränkt oder haben den Nachteil eines geringen Prozesswirkungsgrads. Eine vielversprechende Route ist die chemische Energiespeicherung über Wasserstoff in energietragenden Stoffe (ETS). Dieser Weg stellt eine verlustfreie Speicherung regenerativer Energie in frei wählbaren Zeiträumen in Aussicht. Es werden Effizienzwerte für die Prozessketten Methanisierung und ETS berechnet und gegenübergestellt.
Why as a Medicinal Chemist I Am Not Optimistic about the Possibility of Finding, in a Reasonable Timeframe, Small‐Molecule Drugs Capable of Curing the Evolution of Alzheimer’s Disease
Authors: Kraus Jean‐Louis 
Published: October 2011

AbstractHerein I explain why I feel that new and effective Alzheimer′s disease (AD) drugs cannot emerge from current developed concepts such as the amyloid pathway, or acetylcholinesterase inhibitors. The discovery of new therapeutic approaches first requires an understanding of the intimate structure of brain matter, where memory and cognition are located, and how aging alters its structure and function. Only by joining the expertise of quantum physicists and physical chemists with that of medicinal chemists, pharmacologists, biologists and medical doctors can new AD research orientations emerge.
Biologically‐inspired clustering of semantic Web services. Birds or ants intelligence?
Authors: Pop Cristina Bianca , Chifu Viorica Rozina , Salomie Ioan , Dinsoreanu Mihaela , David Tudor , Acretoaie Vlad , Nagy Aliz , Oprisa Ciprian 
Published: October 2011

SUMMARYThe clustering and sorting behavior of ants, as well as the foraging behavior of birds in nature represented sources of inspiration for designing clustering methods applicable in computer science. This paper investigates how biologically‐inspired clustering methods can be adapted to cluster Semantic Web services aiming at the efficiency of the discovery process. The methods consider the semantic similarity between services as the main clustering criterion. To measure the semantic similarity between two services, we propose a matching method that evaluates the degree of match between the semantic description of the two services. We have tested the biologically‐inspired clustering methods on the SAWSDL service retrieval test collection (SAWSDL‐TC) benchmark, and we have comparatively evaluated their performance using the Dunn index and the Average‐Item Cluster Similarity metric, the latter being introduced in this paper. Copyright © 2011 John Wiley & Sons, Ltd.
Inducing Growth of FeNi–Pt Match‐Like Magnetic Nanoheterostructures on Pt Nanotips and Dechlorination of Hydrochloric Ether
Authors: Wen Ming , Zhang Fan , Cheng Mingzhu , Wu Qingsheng , Sun Baolei , Sun Yuzhen 
Published: October 2011

AbstractNewly designed magnetic FeNi–Pt match‐like heterostructured nanorods were synthesized by means of induced growth of FeNi nanorods on Pt nanotips. The proposed synthesis mechanism is corroborated by SEM, TEM, XRD and XPS. The magnetic behavior shows that the magnetic saturation and coercivity are strongly dependent on both the shape and the alloy composition. The saturation magnetizations (Ms) and the coercivity (Hc) of nanorods synthesized are larger than those of nanoparticles because of the relatively large anisotropy of nanorods. Maximum saturation magnetization is obtained for Fe82Ni15–Pt3 at 226.6 emu g−1, whereas maximum coercivity is obtained for Fe20Ni77–Pt3 at 136.8 Oe. Shape‐dependent reactivity toward the reduction of chlorinated solvents was observed for the FeNi–Pt heterostructured nanomaterials. In particular, the Fe82Ni15–Pt3 nanorods are highly reactive in the dechlorination process of 1,1,2,2‐tetrachloroethane.
A common‐mode replica compensated inductor–capacitor voltage‐controlled oscillator for mixed‐signal system‐on‐chip applications
Authors: Xu Weilin , Chen Xi , Wang Gaofeng 
Published: October 2011

SUMMARYA novel 1.57 GHz complementary metal–oxide semiconductor inductor–capacitor voltage‐controlled oscillator with the common‐mode replica compensation is introduced for mixed‐signal system‐on‐chip applications. In order to alleviate power line disturbances, the center tap node of differential symmetric inductor and the replica biasing circuit are adopted in the differential voltage regulating unit to reduce power supply sensitivity. In addition, this proposed design also leads to low tuning gain and low power dissipation. The post‐layout simulation results under the Taiwan Semiconductor Manufacturing Company's mixed‐signal 0.18 µm 1P6M process show that the proposed design achieves power supply rejection of −68.6 dB at low frequencies and 1.2 MHz/V pushing sensitivity. It exhibits phase noise of −130.6 dBc/Hz at a 1 MHz offset from a 1.57 GHz carrier yet dissipates only 5.58 mW under a 1.8 V power supply. Copyright © 2011 John Wiley & Sons, Ltd.
Realization of a general all‐pole current transfer function by using CBTA
Authors: Koksal Muhammet 
Published: October 2011

ABSTRACTIn this article, a general all‐pole current transfer function synthesis procedure using current backward transconductance amplifiers (CBTAs) is proposed. The proposed configuration uses n current backward transconductance amplifiers and n grounded capacitors as the only type of passive elements. The circuit is eligible to realize any all‐pole transfer characteristics with a given strictly Hurwitz (stable) denominator polynomial. Further, it is straightforward to find the values of the passive elements from the coefficients of this polynomial by using the Routh–Hurwitz algorithm as in the realization of a two‐element kind passive network synthesis. In this sense and as far as the author's knowledge, it is the only active structure that can be synthesized like a passive two‐element kind Cauer circuit. The simulations that are performed using PSPICE exhibit satisfactory results coherent with the theory. Copyright © 2011 John Wiley & Sons, Ltd.
Quantitative gene expression profiling of CD45+ and CD45− skeletal muscle‐derived side population cells
Authors: Andersen Ditte Caroline , Kristiansen Gitte Qvist , Jensen Line , Füchtbauer Ernst‐Martin , Schrøder Henrik Daa , Jensen Charlotte Harken 
Published: October 2011

AbstractThe skeletal muscle‐derived side population (mSP) which highly excludes Hoechst 33342 is composed of CD45+ and CD45− subpopulations; yet, rareness of mSP cells in general has complicated extensive quantitative analysis of gene expression profiles in primarily isolated mSP cells. Here, we describe the isolation of adult mouse normal skeletal muscle residing SPCD45+ and SPCD45− cells from a parent mononuclear muscle‐derived cell (MDC) population. Relative quantitative real time PCR (RT‐PCR) of 64 genes revealed that mSPCD45− compared with mSPCD45+ was enriched for cells expressing transcripts associated with endothelial cells, Notch signaling and myogenic precursors. By comparing the mRNA signatures of mSPs with those of adipose tissue‐derived SP populations, a common endothelial component seemed to reside in both muscle and fat‐derived SPCD45− entities. However, each SP subset was clearly specified by the tissue from which the cells originated suggesting that muscle SPs compared with adipose tissue SPs are predisposed towards differentiation into the myogenic lineage. Thus, our data support the previously suggested hypothesis that satellite cell precursors (or alternatively a satellite cell subpopulation) remain in the mSPCD45− fraction, and we show that these cells express high levels of many of the known myogenic precursor/stem cell related markers, including Pax7 and Myf5. © 2011 International Society for Advancement of Cytometry
Artificial neural network in diagnosis of lobular carcinoma of breast in fine‐needle aspiration cytology
Authors: Dey Pranab , Logasundaram Rajesh , Joshi Kusum 
Published: October 2011

AbstractIn this study, we applied artificial neural network (ANN) for the diagnosis of lobular carcinoma in fine‐needle aspiration cytology (FNAC) material. We selected a total of 64 cases of histology proven breast lesions consisting of 20 fibroadenomas, 28 infiltrating ductal carcinomas (IDC), and 16 infiltrating lobular carcinomas (ILC). Detailed cytomorphological features were studied on representative Haematoxylin–Eosin (H&E) and May‐Grunwald Giemsa stained slides. Image morphometric analysis was performed on Haematoxylin–Eosin stained smears to study nuclear area, diameter, perimeter, roundness, convex area, and convex perimeter. Both the qualitative cytological features and objective morphometric data were collected and a total of 18 variables were studied. Back propagation ANN was designed and this data were used as input values. ANN network was designed as 34‐17‐3. There were a total of 34 first layers neurons, 17 hidden neurons and three output neurons. The total cases were randomly divided automatically by the program into three groups: training set (40), validation set (8), and test set (16). After the successful training, the program was able to differentiate all the benign and lobular carcinoma cases and majority of the ductal carcinoma cases. In test set, the ANN program successfully classified all the cases of benign, and ILC cases and six of seven IDC cases. A suitably designed ANN may be able to diagnose the lobular carcinoma of breast on FNAC material. ANN is an efficient software program with immense potential. Diagn. Cytopathol. 2013. © 2011 Wiley Periodicals, Inc.
Distribution of human papillomavirus among women with abnormal cervical cytology in Kuwait
Authors: Al‐Awadhi Rana , Chehadeh Wassim , Jaragh Mohammad , Al‐Shaheen Azza , Sharma Prem , Kapila Kusum 
Published: October 2011

AbstractThis study investigates the distribution of human papillomavirus (HPV) in women with abnormal cervical cytology in Kuwait. Two hundred and ninety‐eight (298) abnormal ThinPreps were taken from women seeking routine gynecological care and screened for HPV DNA by real‐time PCR. HPV genotyping was determined by PCR‐based sequencing. HPV DNA was detected in 152 women (51%), and 29 different HPV genotypes were detected, comprising 16 high‐risk (HR) (16, 18, 31, 33, 35, 39, 45, 51, 53, 56, 58, 59, 66, 68, 73, 97), nine low‐risk (LR) (6, 11, 54, 61, 74, 81, 90, 102, 106), and four intermediate‐risk (IR) (62, 67, 84, 87). HPV16 had the highest prevalence (24.3%), followed by HPV11 (13.8%), HPV66 (11.2%), HPV33 (9.9%), HPV53 (9.2%), HPV81 (9.2%), HPV56 (7.9%) and HPV18 (6.6%). HPV prevalence was 86, 67, and 89% in women with invasive cervical carcinoma (ICC), high‐grade squamous intraepithelial lesion (HSIL) and low‐grade squamous intraepithelial lesion (LSIL), respectively. As for age distribution, 69% of all HPVs were found in women aged 20–29 years, and the HPV incidence rate deceased with increasing age. The proportion of single infections decreased as the severity of the cytological diagnosis increased, while the proportion of multiple infections increased. This study is the first of its type in Kuwait and one of few in the Middle East. The findings are consistent with the hypothesis that HPV infection is the primary cause of cervical neoplasia. They support HPV vaccine research to prevent cervical cancer and efforts to develop HPV DNA diagnostic tests. Diagn. Cytopathol. 2013. © 2011 Wiley Periodicals, Inc.
Fine‐needle aspiration cytology of abdominal wall endometriosis
Authors: Kim Jung Yeon , Kwon Ji Eun , Kim Hyun‐Jung , Park Kyeongmee 
Published: October 2011

AbstractWhile about 15% of menstruating women develop endometriosis, abdominal wall endometriosis is relatively rare. We present 10 cases of abdominal wall endometriosis diagnosed by fine‐needle aspiration (FNA) cytology and confirmed by subsequent surgical excision. A palpable abdominal wall mass was the most common symptom, followed by pain. Nine cases were associated with previous surgery. The smear showed glandular epithelial cells and spindle or ovoid stromal cells accompanied by macrophages in eight cases. The nucleus was round‐to‐oval and the nucleolus was inconspicuous. Mitosis was not observed in any case. In two cases, which were suspicious of malignancy on FNA, the epithelial cells showed anisonucleosis, hyperchromasia, and small conspicuous nucleoli. The stromal cells were spindle or ovoid in shape, without metaplastic changes. Histiocytes were noted in nine cases and hemosiderin‐laden histiocytes were noted in two cases. The proportion of inflammatory cells varied. FNA diagnosis of abdominal wall endometriosis is possible when the cytological features are interpreted cautiously, together with the patient's clinical history. An accurate diagnosis on FNA will prevent unnecessary surgery. Diagn. Cytopathol. 2013. © 2011 Wiley Periodicals, Inc.