bluuebunny/crossref_metadata_2025_split huggingface dataset:
Probing hadron–quark phase transition in twin stars using f-modes
Authors: Pradhan Bikram K , Chatterjee Debarati , Alvarez-Castillo David Edwin 
Published: June 2024

ABSTRACT
Although it is conjectured that a phase transitions from hadronic to deconfined quark matter in the ultrahigh-density environment of neutron stars (NS), the nature of phase transition remains an unresolved mystery. Furthermore, recent efforts reveal that the finite surface tension effects can lead to a mixed phase with different geometric shapes (so-called ‘pasta’ phases), leading to a smooth phase transition from hadronic to quark matter in the NS interior. Depending on whether there is a strong or a pasta-induced smooth first-order phase transition, one may expect a third family of stable, compact stars or ‘twin stars’ to appear, with the same mass but different radii compared to NSs. The possibility of identifying twin stars using astrophysical observations has been a subject of interest. This study investigates the potential of probing the nature of the hadron–quark phase transition through future gravitational wave (GW) detections from fundamental (f-) mode oscillations in NSs. Using a newly developed model that parametrizes the hadron–quark phase transition with ‘pasta phases’, we calculate f-mode characteristics within a full general relativistic framework. We then use universal relations in GW asteroseismology to derive stellar properties from the detected mode parameters. Our findings suggest that detecting GWs from f modes with third-generation GW detectors offers a promising scenario for the existence of twin stars. However, we also estimate various uncertainties in determining the mode parameters and conclude that these uncertainties make it more challenging to identify the nature of the hadron–quark phase transition.
phyloBARCODER: A Web Tool for Phylogenetic Classification of Eukaryote Metabarcodes Using Custom Reference Databases
Authors: Inoue Jun , Shinzato Chuya , Hirai Junya , Itoh Sachihiko , Minegishi Yuki , Ito Shin-ichi , Hyodo Susumu 
Published: June 2024

Abstract
We developed phyloBARCODER (https://github.com/jun-inoue/phyloBARCODER), a new web tool that can identify short DNA sequences to the species level using metabarcoding. phyloBARCODER estimates phylogenetic trees based on the uploaded anonymous DNA sequences and reference sequences from databases. Without such phylogenetic contexts, alternative, similarity-based methods independently identify species names and anonymous sequences of the same group by pairwise comparisons between queries and database sequences, with the caveat that they must match exactly or very closely. By putting metabarcoding sequences into a phylogenetic context, phyloBARCODER accurately identifies (i) species or classification of query sequences and (ii) anonymous sequences associated with the same species or even with populations of query sequences, with clear and accurate explanations. Version 1 of phyloBARCODER stores a database comprising all eukaryotic mitochondrial gene sequences. Moreover, by uploading their own databases, phyloBARCODER users can conduct species identification specialized for sequences obtained from a local geographic region or those of nonmitochondrial genes, e.g. ITS or rbcL.
Targeting IGF2 to reprogram the tumor microenvironment for enhanced viro-immunotherapy
Authors: Noh Min Hye , Kang Jin Muk , Miller Alexandra A , Nguyen Grace , Huang Minxin , Shim Ji Seon , Bueso-Perez Alberto J , Murphy Sara A , Rivera-Caraballo Kimberly A , Otani Yoshihiro , Kim Eunju , Yoo Seung-Hee , Yan Yuanqing , Banasavadi-Siddegowda Yeshavanth , Nakashima Hiroshi , Chiocca E Antonio , Kaur Balveen , Zhao Zhongming , Lee Tae Jin , Yoo Ji Young 
Published: June 2024

Abstract

Background
The FDA approval of oncolytic herpes simplex-1 virus (oHSV) therapy underscores its therapeutic promise and safety as a cancer immunotherapy. Despite this promise, the current efficacy of oHSV is significantly limited to a small subset of patients largely due to the resistance in tumor and tumor microenvironment (TME).

Methods
RNA sequencing (RNA-Seq) was used to identify molecular targets of oHSV resistance. Intracranial human and murine glioma or breast cancer brain metastasis (BCBM) tumor-bearing mouse models were employed to elucidate the mechanism underlying oHSV therapy-induced resistance.

Results
Transcriptome analysis identified IGF2 as one of the top-secreted proteins following oHSV treatment. Moreover, IGF2 expression was significantly upregulated in 10 out of 14 recurrent GBM patients after treatment with oHSV, rQNestin34.5v.2 (71.4%; P = .0020) (ClinicalTrials.gov, NCT03152318). Depletion of IGF2 substantially enhanced oHSV-mediated tumor cell killing in vitro and improved survival of mice bearing BCBM tumors in vivo. To mitigate the oHSV-induced IGF2 in the TME, we constructed a novel oHSV, oHSV-D11mt, secreting a modified IGF2R domain 11 (IGF2RD11mt) that acts as IGF2 decoy receptor. Selective blocking of IGF2 by IGF2RD11mt significantly increased cytotoxicity, reduced oHSV-induced neutrophils/PMN-MDSCs infiltration, and reduced secretion of immune suppressive/proangiogenic cytokines, while increased CD8 + cytotoxic T lymphocytes (CTLs) infiltration, leading to enhanced survival in GBM or BCBM tumor-bearing mice.

Conclusions
This is the first study reporting that oHSV-induced secreted IGF2 exerts a critical role in resistance to oHSV therapy, which can be overcome by oHSV-D11mt as a promising therapeutic advance for enhanced viro-immunotherapy.
Chronic Liver Enzyme Elevation and Use of Contemporary ARVs Among People With HIV
Authors: Roen Ashley O , Peters Lars , Wandeler Gilles , van der Valk Marc , Zangerle Robert , Günthard Huldrych F , Wit Ferdinand , Mussini Cristina , De Wit Stéphane , d’Arminio Monforte Antonella , Vehreschild Jörg Janne , Castagna Antonella , Jaschinski Nadine , Vannappagari Vani , Chen Linda , Tallada Joan , C’mar John , Mocroft Amanda , Ryom Lene 
Published: June 2024

Abstract

Background
While use of some older antiretroviral drugs (ARVs) is associated with chronic liver enzyme elevation (cLEE), the impact of newer ARVs remains unknown.

Methods
People with HIV enrolled in the RESPOND cohort who started an ARV after January 1, 2012 were included (baseline). The primary outcome was first cLEE individuals were censored at first of cLEE, last visit, death, or December 31, 2021. Incidence rates (IRs; events/1000 person-years) were calculated for each ARV overall and by ARV exposure (6–12 months, 1–2 years, and 2+ years). Poisson regression was used to estimate the incidence rate ratio (IRR) of cLEE and its association with individual ARVs and ARV class.

Results
Of 17 106 individuals included contributing 87 924 person-years of follow-up, 1932 (11.3%) experienced cLEE (incidence rate [IR], 22.0; 95% CI, 21.0–23.0). There was no evidence of a cumulative ARV effect on cLEE incidence, (6–12 months: IR, 45.8; 95% CI, 41.4–50.19; 1–2 years: IR, 34.3; 95% CI, 31.5–37.4; and 2+ years: IR, 18.5; 95% CI, 17.4–19.7). Any use (vs no prior use) of non-nucleoside reverse transcriptase inhibitors (NNRTIs) as a class and tenofovir disoproxil fumarate (TDF) was independently associated with an increased IRR of cLEE, and any use of darunavir (DRV) was associated with a decreased risk of cLEE.

Conclusions
cLEE is common and more frequent during the first year after initiating new ARVs. With a &gt;5-year median follow-up, we found no short-term liver safety concerns with the use of INSTIs. Use of NNRTIs and TDF was associated with an increased cLEE risk, while DRV was associated with lower risk.
Broad-band non-thermal emission of odd radio circles induced by explosive galactic outflow remnants and their evolution
Authors: Fujita Yutaka , Kawanaka Norita , Inoue Susumu 
Published: June 2024

Abstract
Odd radio circles (ORCs) are mysterious rings of faint, diffuse emission recently discovered in radio surveys, some of which may be associated with galaxies in relatively dense environments. We propose that such ORCs are synchrotron emission from remnants of explosive galactic outflows, calling them OGREs, and discuss their broad-band non-thermal emission and evolution. We posit that a large amount of energy was ejected from the central galaxy in the past, creating an outgoing shock that accelerates cosmic rays. Assuming plausible values for the density, temperature and magnetic field of the ambient medium, consistency with the observed spectral index, size, and power of the ORCs requires the energy to be as high as ∼1060 erg, suggesting that their sources could be active galactic nuclei. We calculate the spectral energy distributions (SEDs) of the OGREs and their evolution, including synchrotron, inverse Compton (IC), and bremsstrahlung emission from electrons, and pion-decay emission from protons. We find that the SEDs of the younger OGREs are not greatly different from those of older ones currently observable as ORCs if radiative cooling of electrons is effective. As such younger OGREs are expected to be rarer and smaller, they may not be readily observable. However, if radiative cooling of electrons is ineffective, younger OGREs may be detectable in X-rays.
Absence of alka(e)nes triggers profound remodeling of glycerolipid and carotenoid composition in cyanobacteria membrane
Authors: Miao Rui , Légeret Bertrand , Cuine Stéphan , Burlacot Adrien , Lindblad Peter , Li-Beisson Yonghua , Beisson Fred , Peltier Gilles 
Published: June 2024

Abstract
Alka(e)nes are produced by many living organisms and exhibit diverse physiological roles, reflecting a high functional versatility. Alka(e)nes serve as waterproof wax in plants, communicating pheromones for insects, and microbial signaling molecules in some bacteria. Although alka(e)nes have been found in cyanobacteria and algal chloroplasts, their importance for photosynthetic membranes has remained elusive. In this study, we investigated the consequences of the absence of alka(e)nes on membrane lipid composition and photosynthesis using the cyanobacterium Synechocystis PCC6803 as a model organism. By following the dynamics of membrane lipids and the photosynthetic performance in strains defected and altered in alka(e)ne biosynthesis, we show that drastic changes in the glycerolipid contents occur in the absence of alka(e)nes, including a decrease in the membrane carotenoid content, a decrease in some digalactosyldiacylglycerol (DGDG) species and a parallel increase in monogalactosyldiacylglycerol (MGDG) species. These changes are associated with a higher susceptibility of photosynthesis and growth to high light in alka(e)ne-deficient strains. All these phenotypes are reversed by expressing an algal photoenzyme producing alka(e)nes from fatty acids. Therefore, alkenes, despite their low abundance, are an essential component of the lipid composition of membranes. The profound remodeling of lipid composition that results from their absence suggests that they play an important role in one or more membrane properties in cyanobacteria. Moreover, the lipid compensatory mechanism observed is not sufficient to restore normal functioning of the photosynthetic membranes, particularly under high-light intensity. We conclude that alka(e)nes play a crucial role in maintaining the lipid homeostasis of thylakoid membranes, thereby contributing to the proper functioning of photosynthesis, particularly under elevated light intensities.
A COBRA family protein, PtrCOB3, contributes to gelatinous layer formation of tension wood fibers in poplar
Authors: Xu Wenjing , Cheng Hao , Cheng Jiyao , Zhu Siran , Cui Yongyao , Wang Chong , Wu Jianzhen , Lan Xingguo , Cheng Yuxiang 
Published: June 2024

Abstract
Angiosperm trees usually develop tension wood (TW) in response to gravitational stimulation. TW comprises abundant gelatinous (G-) fibers with thick G-layers primarily composed of crystalline cellulose. Understanding the pivotal factors governing G-layer formation in TW fiber remains elusive. This study elucidates the role of a Populus trichocarpa COBRA family protein, PtrCOB3, in the G-layer formation of TW fibers. PtrCOB3 expression was upregulated, and its promoter activity was enhanced during TW formation. Comparative analysis with wild-type trees revealed that ptrcob3 mutants, mediated by Cas9/gRNA gene editing, were incapable of producing G-layers within TW fibers and showed severely impaired stem lift. Fluorescence immunolabeling data revealed a dearth of crystalline cellulose in the tertiary cell wall (TCW) of ptrcob3 TW fibers. The role of PtrCOB3 in G-layer formation is contingent upon its native promoter, as evidenced by the comparative phenotypic assessments of pCOB11::PtrCOB3, pCOB3::PtrCOB3, and pCOB3::PtrCOB11 transgenic lines in the ptrcob3 background. Overexpression of PtrCOB3 under the control of its native promoter expedited G-layer formation within TW fibers. We further identified 3 transcription factors that bind to the PtrCOB3 promoter and positively regulate its transcriptional levels. Alongside the primary TCW synthesis genes, these findings enable the construction of a 2-layer transcriptional regulatory network for the G-layer formation of TW fibers. Overall, this study uncovers mechanistic insight into TW formation, whereby a specific COB protein executes the deposition of cellulose, and consequently, G-layer formation within TW fibers.
Tubulin participates in establishing protoxylem vessel reinforcement patterns and hydraulic conductivity in maize
Authors: Huang Shiquan , Guo Siyi , Dai Liufeng , Mi Lingyu , Li Wenrao , Xing Jingjing , Hu Zhubing , Wu Wenqiang , Duan Zhikun , Li Baozhu , Sun Ting , Wang Baojie , Zhang Yi , Xiao Tiqiao , Xue Yanling , Tang Ning , Li Han , Zhang Changqing , Song Chun-Peng 
Published: June 2024

Abstract
Water transportation to developing tissues relies on the structure and function of plant xylem cells. Plant microtubules govern the direction of cellulose microfibrils and guide secondary cell wall formation and morphogenesis. However, the relevance of microtubule-determined xylem wall thickening patterns in plant hydraulic conductivity remains unclear. In the present study, we identified a maize (Zea mays) semi-dominant mutant, designated drought-overly-sensitive1 (ZmDos1), the upper leaves of which wilted even when exposed to well-watered conditions during growth; the wilting phenotype was aggravated by increased temperatures and decreased humidity. Protoxylem vessels in the stem and leaves of the mutant showed altered thickening patterns of the secondary cell wall (from annular to spiral), decreased inner diameters, and limited water transport efficiency. The causal mutation for this phenotype was found to be a G-to-A mutation in the maize gene α-tubulin4, resulting in a single amino acid substitution at position 196 (E196K). Ectopic expression of the mutant α-tubulin4 in Arabidopsis (Arabidopsis thaliana) changed the orientation of microtubule arrays, suggesting a determinant role of this gene in microtubule assembly and secondary cell wall thickening. Our findings suggest that the spiral wall thickenings triggered by the α-tubulin mutation are stretched during organ elongation, causing a smaller inner diameter of the protoxylem vessels and affecting water transport in maize. This study underscores the importance of tubulin-mediated protoxylem wall thickening in regulating plant hydraulics, improves our understanding of the relationships between protoxylem structural features and functions, and offers candidate genes for the genetic enhancement of maize.
Federal Judges, States Legislators, and State Voting Rights Rollback
Authors: Woodward-Burns Robinson 
Published: June 2024

AbstractThis article claims that recent Supreme Court decisions have allowed state lawmakers to suppress and skew but not subvert the vote. The Court relaxed federal oversight of state election administration in Shelby County v. Holder (2013), Abbott v. Perez (2018), and Brnovich v. Democratic National Committee (2021), and gerrymandering in Rucho v. Common Cause (2019), while prohibiting independent state legislative election regulation in Moore v. Harper (2023). These decisions guided state lawmakers toward vote suppression and skewing, and away from election subversion. Consequently, Republican state legislatures have passed state constitutional amendments and statutes limiting ballot access and reforming state redistricting practices. While some Democratic state legislatures have protected ballot access and independent redistricting, these recent Supreme Court decisions help Republicans win a disproportionate share of state legislative seats. National courts thus help preserve the national party coalition by opening subnational jurisdictions to party entrenchment.
Motivic Geometry of two-Loop Feynman Integrals
Authors: Doran Charles F , Harder Andrew , Vanhove Pierre , Pichon-Pharabod Eric 
Published: June 2024

Abstract
We study the geometry and Hodge theory of the cubic hypersurfaces attached to two-loop Feynman integrals for generic physical parameters. We show that the Hodge structure attached to planar two-loop Feynman graphs decomposes into mixed Tate pieces and the Hodge structures of families of hyperelliptic, elliptic or rational curves depending on the space-time dimension. For two-loop graphs with a small number of edges, we give more precise results. In particular, we recover a result of Bloch (Double box motive. SIGMA 2021;17,048) that in the well-known double-box example, there is an underlying family of elliptic curves, and we give a concrete description of these elliptic curves. We show that the motive for the non-planar two-loop tardigrade graph is that of a K3 surface. In an appendix by Eric Pichon-Pharabod, we argue via high-precision numerical computations that the Picard number of this K3 surface is generically 11 and we compute the expected lattice polarization. Lastly, we show that generic members of the ice cream cone family of graph hypersurfaces correspond to the pairs of sunset Calabi–Yau varieties.
The thermoluminescence glow curves of LiF:Mg,Ti: characteristics and mechanisms
Authors: Horowitz Yigal Shalom , Oster Leonid 
Published: June 2024

Abstract
The features of the glow curves of LiF:Mg,Ti are dependent on many parameters of irradiation, storage, ionisation density and readout. These are presented herein with emphasis on their complexity. Successful applications require some understanding of the great diversity of the glow curves. Glow curve analysis/deconvolution in order to better understand the mechanisms is a ‘tricky business’ even with Tm-Tstop analysis. In the theoretical framework of spatially correlated trapping and luminescent centres, a mechanism is described which simulates the behaviour of composite peak 5 at different cooling rates and following photon bleaching at 3.65 eV.
Assessment of natural radioactivity in the RCC building materials used in the valley region of Manipur, India
Authors: Sharma Brahmacharimayum Arunkumar , Devi Angom Ronibala 
Published: June 2024

Abstract
An assessment of radioactivity concentration of reinforced cement concrete types of house was conducted in the valley region of Manipur, India. The average radioactivity concentration of 226Ra, 232Th, and 40K of portland cements are 39 (range: 32–52) Bqkg−1, 36 (range: 22–62) Bqkg−1, and 1812 (1254–2424) Bqkg−1; for concrete are 36 (range: 26–45) Bqkg−1, 65 (range: 45–86) Bqkg−1, and 660 (639–681) Bqkg−1; for sand are 45 (30–61) Bqkg−1, 114 (range: 55–212) Bqkg−1, and 1859 (range: 1413–2232) Bqkg−1; and for bricks are 30 (range: 24–37) Bqkg−1, 148 (range:79–184) Bqkg−1, and 1444 (range: 1093–2103) Bqkg−1, respectively. The annual effective dose was observed with an average value of 1.9 (range: 0.9–3.3) mSvy−1. However, gamma index was observed with an average value of 1.1 (range: 0.5–2.0).
The scent of cuteness—neural signatures of infant body odors
Authors: Schäfer Laura , Köppel Carina , Kreßner-Kiel Denise , Schwerdtfeger Sarah , Michael Marie , Weidner Kerstin , Croy Ilona 
Published: June 2024

Abstract
The smell of the own baby is a salient cue for human kin recognition and bonding. We hypothesized that infant body odors function like other cues of the Kindchenschema by recruiting neural circuits of pleasure and reward. In two functional magnetic resonance imaging studies, we presented infantile and post-pubertal body odors to nulliparae and mothers (N = 78). All body odors increased blood-oxygen-level-dependent (BOLD) response and functional connectivity in circuits related to olfactory perception, pleasure and reward. Neural activation strength in pleasure and reward areas positively correlated with perceptual ratings across all participants. Compared to body odor of post-pubertal children, infant body odors specifically enhanced BOLD signal and functional connectivity in reward and pleasure circuits, suggesting that infantile body odors prime the brain for prosocial interaction. This supports the idea that infant body odors are part of the Kindchenschema. The additional observation of functional connectivity being related to maternal and kin state speaks for experience-dependent priming.
Points of departure: family leave policy and women’s representation in management in U.S. workplaces
Authors: Mun Eunmi , Vican Shawna , Kelly Erin L 
Published: June 2024

Abstract
This paper theorizes the interplay of public and organizational policies by investigating whether the Family and Medical Leave Act (FMLA) shifted patterns of gender inequality within U.S. workplaces. Did this leave law increase women’s representation in positions of authority (moving more women into management jobs)? We argue that the impact of public policies will vary by organizational context, hypothesizing different effects by organizations’ points of departure—the corporate policies in place when public policy changes. Analyzing establishment-level panel data from approximately 800 U.S. private-sector establishments in 1990–1997, we found that women’s representation in managerial positions increased in the years immediately after the FMLA. Importantly, women’s representation in management increased the most in workplaces that provided more generous leave benefits even before the FMLA. The increase in managerial representation was most prominent for women of color. Consistent with relational inequality theory, these findings suggest that women may find it easier to make claims for leave and for career advancement when both legal and organizational policies lend legitimacy to their claims. More broadly, this study points to the need to explicitly evaluate how policy impacts vary by organizational norms and commitments.
Social Locations of Secularization and Worldview (Dis)Enchantment: Education, Income, and Belief in Religious and Paranormal Phenomena
Authors: Corcoran Katie E , Scheitle Christopher P , DiGregorio Bernard D 
Published: June 2024

Abstract
Forces of secularization are theorized to disenchant an individual’s worldview—i.e., erode an individual’s belief in nonnatural beings, forces, or abilities. Tests of this proposition, though, have often failed to measure the variety of forms of worldview enchantment found among individuals. Drawing on the broader secularization literature, we theorize correlates of (dis)enchantment and test these predictions using a nationally representative survey of U.S. adults featuring a wide battery of enchanted beliefs. We identify four latent enchanted worldview dimensions and find, consistent with secularization theories, that education and income are consistently and negatively associated with all four worldview enchantment dimensions.