bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluating Existing Ocean Glider Sampling Strategies for Submesoscale Dynamics
Authors: Patmore Ryan D. , Ferreira David , Marshall David P. , du Plessis Marcel D. , Brearley J. Alexander , Swart Sebastiaan 
Published: May 2024

Abstract
Mixing in the upper ocean is important for biological production and the transfer of heat and carbon between the atmosphere and deep ocean, properties commonly targeted by observational campaigns using ocean gliders. We assess the reliability of ocean gliders to obtain a robust statistical representation of submesoscale variability in the ocean mixed layer of the Weddell Sea. A 1/48° regional simulation of the Southern Ocean is sampled with virtual “bow-tie” glider deployments, which are then compared against the reference model output. Sampling biases of lateral buoyancy gradients associated with the arbitrary alignment between glider paths and fronts are formally quantified, and the magnitude of the biases is comparable to observational estimates, with a mean error of 52%. The sampling bias leaves errors in the retrieved distribution of buoyancy gradients largely insensitive to deployment length and the deployment of additional gliders. Notable sensitivity to these choices emerges when the biases are removed by sampling perpendicular to fronts at all times. Detecting seasonal change in the magnitude of buoyancy gradients is sensitive to the glider-orientation sampling bias but the change in variance is not. We evaluate the impact of reducing the number of dives and climbs in an observational campaign and find that small reductions in the number of dive–climb pairs have a limited effect on the results. Lastly, examining the sensitivity of the sampling bias to path orientation indicates that the bias is not dependent on the direction of travel in our deep ocean study site.

Significance Statement
Recent observational campaigns have focused on using autonomous vehicles to better understand processes responsible for mixing in the surface region of the ocean. There exists uncertainty around how effective these missions are at returning reliable and representative information. This study seeks to quantify the performance of existing strategies in observing mixing processes, and we confirm that strategies are biased to underestimate indicators of mixing. Furthermore, compensating for the bias by increasing the number of resources or changing the manner in which resources are used has limited reward. Our findings are important for decision-making during the planning phase of an observational campaign and display that further innovations are required to account for the sampling bias.
A case report of sinonasal glomangiopericytoma: An important reminder to always collect specimen
Authors: Nichol Ariadne A. , Bernard Benjamin J. , Gilani Sapideh 
Published: May 2024

Objectives To present a case report of sinonasal glomangiopericytoma (GPC) in a female patient in her thirties and to highlight the importance of collecting pathology specimens even in routine sinus surgery cases. Methods A case report detailing the diagnosis of GPC in a female in her thirties, including her initial presentation, treatment, and follow-up, along with a brief review of the literature. Results Pathology of the collected specimen revealed sinonasal GPC along with chronic rhinosinusitis. Immunohistochemistry was positive for SMA, beta-catenin, and cyclin D1; and negative for STAT6, ERG, pankeratin, SOX10, and S100. Conclusion This diagnosis expands the knowledge around the demographic profile of GPC patients. GPC should be included in the differential diagnosis of sinonasal masses, even in younger patients. The case highlights the importance of collecting the entire pathology specimen in all cases, even of ones that seem routine and benign.
Hybrid of micro-aramid and nano-alumina prominently enhanced the wear resistance of polytetrafluoroethylene composites
Authors: Tian Ying , Li Ruojia , Wang Zhuang , Zheng Shaomei , Che Qinlgun , Zhang Jianjun 
Published: May 2024

Polymer self-lubricating composites are key in reducing energy consumption from friction, boasting self-lubrication, remarkable wear, and corrosion resistance. This study delves into the unexpected synergy between micro-aramid and nano-Al2O3 in enhancing PTFE’s wear resistance. The results exhibit that the optimal hybrid of 15 vol.% micro-aramid and 1 vol.% nano-Al2O3 particles enhanced the PTFE composites has carried out the best tribological properties, showing synergistic anti-friction and anti-wear effects and obtaining the very low wear rate of 8.73 × 10−7 mm3/Nm, which is decreased by 53% and 98.7% in comparison with separate enhancement of the PTFE composites with 15 vol.% micro-aramid and 1 vol.% nano-Al2O3, respectively. In-depth characterization and analysis of the friction interface are confirmed that PTFE generating carboxylic acid groups during the friction process chelated with the dual steel surface, micro-aramid producing the interaction of the strong polarity with the dual steel, and mechanical stress and high flash temperature promoting friction sintering of nano-Al2O3 to enhance bearing capacity are cooperatively endowed a robustness protective tribofilm with easy shearing and high bearing properties, which effectively enhances the tribological properties of PTFE composites, providing a reference for the research and design of new nano composites with ultra-low wear and self-lubricating properties.
Headache in systemic lupus erythematosus: The LUNA registry cross-sectional study
Authors: Takamatsu Ryota , Shimojima Yasuhiro , Kishida Dai , Ichikawa Takanori , Ueno Ken-ichi , Miyawaki Yoshia , Yajima Nobuyuki , Sada Ken-Ei , Ichinose Kunihiro , Yoshimi Ryusuke , Ohno Shigeru , Kajiyama Hiroshi , Fujiwara Michio , Sato Shuzo , Kida Takashi , Matsuo Yusuke , Nishimura Keisuke , Toriyama Toshihide , Sekijima Yoshiki 
Published: May 2024

Objectives This study investigated the clinically relevant factors for headaches in patients with systemic lupus erythematosus (SLE) using a registry from a Japanese multicenter cohort. Methods This cross-sectional study analysed the clinical information of patients with SLE who experienced headache episodes using the Migraine Disability Assessment (MIDAS) questionnaire. Significant findings in the comparisons between patients with headache (HA patients) and those without headache (non-HA patients) and in the comparisons depending on the grades of headache-induced disability in daily life based on the MIDAS scores were evaluated. Multivariate logistic regression analyses were performed to identify the relevant factors for headache. Results We analyzed 369 patients (median age, 45 years; female, 90.8%), including 113 HA patients who were significantly younger than non-HA patients ( p < .005). HA patients had significantly higher frequencies of photosensitivity, rashes, and mucosal ulcers than non-HA patients ( p < .05). Age and photosensitivity were significantly associated with headache (odds ratio (OR) 0.93, 95% confidence interval (CI) 0.95–0.99; OR 2.11, 95% CI 1.29–3.49, respectively). In the HA patients, hypocomplementemia was significantly associated with a disability of more than mild grade (OR 2.89, 95% CI 1.14–7.74), while rash was significantly observed in those presenting with moderate and severe disability. Conclusion This study suggests that photosensitivity is a relevant manifestation of headache in patients with SLE. Persistent hypocomplementemia can contribute to headache-induced disability in daily life, whereas a rash may be a dominant manifestation in patients presenting with moderate/severe headache-induced disability.
To Hinder or to Facilitate: Retailers’ Strategy of Consumer Information Sharing
Authors: Ma Buqing , Li Guang , Kong Guangwen 
Published: May 2024

Consumer information sharing is considered an effective strategy to attract consumers, yet certain high-end retailers, such as Bergdorf Goodman and Farfetch, tend to hinder consumers from sharing information through online reviews. We study a retailer’s strategy for consumer information sharing in a supply chain. We find that a retailer’s information sharing strategy can prevent manufacturers from extracting excessive profit when consumers are heterogeneous in their valuations of the selling product. Specifically, a retailer can achieve a higher profit margin by targeting all consumer segments. By strategically choosing the information sharing strategy to influence consumer beliefs, the retailer can induce the manufacturer to conform to the retailer’s preferred targeting segment through a low wholesale price. Thus, a high-end retailer, whose consumers have a high ex-ante quality belief, favors hindering information sharing among consumers because it enables the retailer to target all consumer segments. Interestingly, deterring consumers from learning about the product quality may generate more consumer surplus. Our main results are robust under extensions such as consumer search behavior, consumer waiting, and multiple product selling. When selling multiple products, a retailer with a large quality variation is better off hindering consumers from sharing information. Our work shows that strategically choosing a consumer information sharing strategy enables retailers to enhance profit margins in their interactions with upstream manufacturers.
Unveiling novel LRP5 pathogenic variant in familial exudative vitreoretinopathy: Diverse phenotypic expressions in a mother-daughter duo
Authors: Chang Hsin-Ho , Wang An-Guor , Niu Dau-Ming , Chen Yun-Ru , Weng Chang-Chi 
Published: May 2024

Purpose This report aims to delineate distinct phenotypes of Familial Exudative Vitreoretinopathy (FEVR) observed in a mother and her daughter, both harboring a novel LRP5 pathogenic variation. Methods The investigation involves a retrospective review of medical records accompanied by multimodal imaging. Molecular characterization was performed using whole exon sequencing, and the pathogenic variant was subsequently confirmed through Sanger sequencing. Result A 6-year-old girl diagnosed with anisometropic amblyopia exhibited macular dragging and peripheral avascular retina in her right eye. Whole exon sequencing identified a previously unreported heterozygous missense LRP5 pathogenic variation, Glu528Lys. Simultaneously, her 43-year-old mother also carried the same mutation, manifesting peripheral exudations, avascular areas, and multiple microaneurysms. Notably, both cases presented distinctive phenotypes of FEVR. Conclusion Our findings underscore the diversity in clinical presentations associated with FEVR, emphasizing the pivotal role of genetic evaluation. Despite variations in severity between the eyes of the same patient, it is crucial to remain vigilant for potential progression to a pathological status in the seemingly normal eye. Additionally, this study contributes to expanding the genetic spectrum of FEVR.
Prevalence of sexual harassment and its association with aspects self-reported health: A cross-sectional study in Sweden
Authors: Hagland Malin , Brandén Gunnar J. , Kosidou Kyriaki , Nielsen Anna M. 
Published: May 2024

Aims: Sexual harassment is common and may have serious consequences for well-being and health. We investigated the prevalence of sexual harassment in the general population of Stockholm County across socio-demographic groups and sexual identity, and its association with self-reported health. Methods: Experiences of sexual harassment in the previous 12 months and its associations with self-reported health (depression, anxiety, suicidal ideation) were assessed in 2021/2022 among a random sample of 22,890 residents in Stockholm County aged 16 and older. Analyses were done using descriptive statistics and multivariate logistic regression (odds ratios and 95% confidence intervals (CI)). Calibration weights were used to estimate population-representative rates with 95% CI. Results: The highest weighted prevalence was observed among 16- to 24-year-olds (18.9%, 95% CI 16.9%–20.9%). Women (9.5%; 95% CI 8.8%–10.1%) reported a higher prevalence than men (2.9%; 95% CI 2.5%–3.3%). Compared to heterosexual people, bisexual and homosexual people reported a higher prevalence of sexual harassment. No significant difference was observed related to country of birth. People who were students, unemployed or on sick leave were more exposed than employed people, although this was not significant when adjusted for age and registered sex. Experiences of sexual harassment was associated with higher odds of all aspects of self-reported health. Conclusions: Experiences of sexual harassment in the general population are common and associated with adverse self-reported health. There is a need for enhanced efforts to prevent sexual harassment in the general population and to empower specific risk groups such as women and sexual minorities.
Homeopathy as Praxis: Integration of Homeopathy as Supportive Care into Daily Life in Early Breast Cancer Patients
Authors: Veyrier Clair-Antoine , Roucoux Guillaume , Baumann-Coblentz Laurence , Massol Jacques , Karp Jean-Claude , Wagner Jean-Philippe , Chassany Olivier , Duracinsky Martin 
Published: May 2024

Introduction: Homeopathy is one of most widely used non-conventional supportive care methods used by women with breast cancer. This article aims to describe the routines and practices related to homeopathy as supportive care used by women with non-metastatic breast cancer in France. Methods: This qualitative study used Grounded Theory. Participants were women with early breast cancer and healthcare professionals (General Practitioner homeopaths & oncologists). Inclusion depended on specific criteria and the aim of theoretical sampling until data saturation. Data were collected through individual semi-structured interviews and focus groups following evolving topic guides. Transcribed interviews underwent in-depth thematic analysis. Inclusion, interviewing, transcription and coding occurred iteratively. Data was reported according to COREQ guidelines. Results: The therapeutic agency of homeopathy was distributed to different actors and ritualized material activities highly involving the patient. The choice of remedy was mostly delegated by patients to General Practitioner homeopaths (GPH) during consultations. Individualization, that is to say adaptation to the patient, differed from other modes of access to homeopathy (self-medication and oncologists). Self-medication was mostly limited to known products in a limited time frame. However, we identified a supported self-medication using trusted homeopathic protocols. Following homeopathic prescriptions involves a high level of commitment on behalf of the patient and follows different rules for homeopathy intake. This knowledge was either acquired earlier for users or discovered along breast cancer treatment for non-users. Taking homeopathy involved small daily actions for intake of different products at different times of the day. New users used strategies to ease the integration of homeopathy into their daily life. The stance toward such rules differed among patients. Some followed rules to optimize their effects while others simplified the rules and took those rituals as part of homeopathy benefits. Conclusion: Homeopathy as supportive care in breast cancer is distributed toward different actors and ritualized activities. Homeopathy is a supported practice where GPH played a role in the prescription. Health Literacy in homeopathy played a role to ease its integration into daily life and identify the potential benefits. The high involvement of patients in their homeopathic treatment is a form of treatment reappropriation and empowerment.
Long-term impact of commonly performed operations in pediatric urology on reproductive and sexual health
Authors: Geada Alexandra , Jivanji Dhaval , Tennenbaum Daniel M. , Ghomeshi Armin , Reddy Raghuram , Sencaj Michael , Thomas Jamie , Nassau Daniel E. , Ramasamy Ranjith 
Published: May 2024

Introduction: Sexual dysfunction is highly prevalent among men of reproductive age. Clinical practice guidelines have been established to assist providers in identification and education of patients who are at increased risk for infertility and sexual dysfunction with certain congenital and acquired urogenital disorders. The authors sought to review the reproductive and sexual health implications of treating common childhood urological conditions with commonly performed surgical procedures. Methods: To ensure the inclusion of influential and highly regarded research, we prioritized citations from the most-frequently cited articles on our respective review topics. Our inclusion criteria considered studies with substantial sample sizes and rigorously designed methodologies. Several topics were reviewed, including penile chordee, hypospadias, posterior urethral valves, varicoceles, undescended testicles, and testicular torsion. Results: For chordee, surgical plication or corporal grafting may be employed. Erectile function remains unaltered post-surgery, while penile length may decrease after repair, which may be avoided using dermal grafts. Hypospadias repair hinges on severity and availability of the urethral plate. Those who underwent hypospadias repair report decreased penile length, but sexual satisfaction, libido, and semen quality are comparable to controls. Posterior urethral valves are usually treated with valve ablation. While valve ablation and bladder neck incision have not been found to affect ejaculatory function, high degree of concurrent renal dysfunction related to nephrogenic and bladder dysfunction may impact semen parameters and erectile function. Regarding varicocele, earlier management has been associated with better long-term fertility outcomes, and surgical intervention is advisable if there is observable testicular atrophy. Earlier repair of undescended testicle with orchiopexy has been found to improve fertility rates as well as decrease malignancy rates. Unilateral orchiectomy for testicular torsion without the ability for salvage has been shown to have decreased semen parameters but unaffected fertility rates. Conclusion: Infertility and sexual dysfunction are multivariable entities, with etiologies both congenital and acquired. At the same time, many common pediatric urology surgeries are performed to correct anatomic pathology that may lead to reproductive dysfunction in adulthood. This review highlights the need for diagnosis and management of pediatric urologic conditions as these conditions may impact long-term sexual function post-operatively.
Assessment of the impact of residual tumors at different sites post-neoadjuvant chemotherapy on prognosis in breast cancer patients and development of a disease-free survival prediction model
Authors: Yang Hanzhao , Ruan Yuxia , Sun Yadong , Wang Peili , Qiao Jianghua , Wang Chengzheng , Liu Zhenzhen 
Published: May 2024

Background: Residual disease after neoadjuvant chemotherapy (NAC) in breast cancer patients predicts worse outcomes than pathological complete response. Differing prognostic impacts based on the anatomical site of residual tumors are not well studied. Objectives: The study aims to assess disease-free survival (DFS) in breast cancer patients with different residual tumor sites following NAC and to develop a nomogram for predicting 1- to 3-year DFS in these patients. Design: A retrospective cohort study. Methods: Retrospective analysis of 953 lymph node-positive breast cancer patients with residual disease post-NAC. Patients were categorized into three groups: residual disease in breast (RDB), residual disease in lymph nodes (RDN), and residual disease in both (RDBN). DFS compared among groups. Patients were divided into a training set and a validation set in a 7:3 ratio. Prognostic factors for DFS were analyzed to develop a nomogram prediction model. Results: RDB patients had superior 3-year DFS of 94.6% versus 85.2% for RDN and 81.8% for RDBN ( p < 0.0001). Clinical T stage, N stage, molecular subtype, and postoperative pN stage were independently associated with DFS on both univariate and multivariate analyses. Nomogram integrating clinical tumor-node-metastasis (TNM) stage, molecular subtype, pathological response demonstrated good discrimination (C-index 0.748 training, 0.796 validation cohort), and calibration. Conclusion: The location of residual disease has prognostic implications, with nodal residuals predicting poorer DFS. The validated nomogram enables personalized DFS prediction to guide treatment decisions.
Development of a nomogram to predict the risk of secondary failure of platelet recovery in patients with β-thalassemia major after hematopoietic stem cell transplantation: a retrospective study
Authors: Xie Yanni , Yang Gaohui , Pan Lin , Gan Zhaoping , Huang Yumei , Lai Yongrong , Liu Rongrong 
Published: May 2024

Background: Secondary failure of platelet recovery (SFPR) is a common complication that influences survival and quality of life of patients with β-thalassemia major (β-TM) after hematopoietic stem cell transplantation (HSCT). Objectives: A model to predict the risk of SFPR in β-TM patients after HSCT was developed. Design: A retrospective study was used to develop the prediction model. Methods: The clinical data for 218 β-TM patients who received HSCT comprised the training set, and those for another 89 patients represented the validation set. The least absolute shrinkage and selection operator regression algorithm was used to identify the critical clinical factors with nonzero coefficients for constructing the nomogram. Calibration curve, C-index, and receiver operating characteristic curve assessments and decision curve analysis (DCA) were used to evaluate the calibration, discrimination, accuracy, and clinical usefulness of the nomogram. Internal and external validation were used to test and verify the predictive model. Results: The nomogram based on pretransplant serum ferritin, hepatomegaly, mycophenolate mofetil use, and posttransplant serum albumin could be conveniently used to predict the SFPR risk of thalassemia patients after HSCT. The calibration curve of the nomogram revealed good concordance between the training and validation sets. The nomogram showed good discrimination with a C-index of 0.780 (95% CI: 70.3–85.7) and 0.868 (95% CI: 78.5–95.1) and AUCs of 0.780 and 0.868 in the training and validation sets, respectively. A high C-index value of 0.766 was reached in the interval validation assessment. DCA confirmed that the nomogram was clinically useful when intervention was decided at the possibility threshold ranging from 3% to 83%. Conclusion: We constructed a nomogram model to predict the risk of SFPR in patients with β-TM after HSCT. The nomogram has a good predictive ability and may be used by clinicians to identify SFPR patients early and recommend effective preventive measures.