bluuebunny/crossref_metadata_2025_split huggingface dataset:
Spreading code optimization for low-earth orbit satellites via mixed-integer convex programming
Authors: Yang Alan , Mina Tara , Gao Grace 
Published: May 2024

AbstractOptimizing the correlation properties of spreading codes is critical for minimizing inter-channel interference in satellite navigation systems. By improving the codes’ correlation sidelobes, we can enhance navigation performance while minimizing the required spreading code lengths. In the case of low-earth orbit (LEO) satellite navigation, shorter code lengths (on the order of a hundred) are preferred due to their ability to achieve fast signal acquisition. Additionally, the relatively high signal-to-noise ratio in LEO systems reduces the need for longer spreading codes to mitigate inter-channel interference. In this work, we propose a two-stage block coordinate descent (BCD) method which optimizes the codes’ correlation properties while enforcing the autocorrelation sidelobe zero property. In each iteration of the BCD method, we solve a mixed-integer convex program over a block of 25 binary variables. Our method is applicable to spreading code families of arbitrary sizes and lengths, and we demonstrate its effectiveness for a problem with 66 length-127 codes and a problem with 130 length-257 codes.
Social farming and educational needs: how kindergarten farms could fill a gap
Authors: Paffarini Chiara , Torquati Biancamaria , Sannipoli Moira , Fabbri Alessia , Cecchini Lucio 
Published: May 2024

AbstractKindergarten farms are educational initiatives aiming to reinforce or even create relationships between nature and future generations involving them in agricultural settings. They take the form of Outdoor Education (OE), intending to enhance the outdoor environment in its various configurations, from an educational perspective. From the agricultural side, these activities are included in social farming (SF), represents a union between the educative sphere and the agriculture world and offering added farm revenue with a multifunctional view. In Italy, these educational services within the farms (‘Agrinidi’ and ‘Agriasili’) have grown recently, contributing to the educational system where services are marginally available or lacking. This study has focused on the families' needs concerning early childhood services in support of work–life balance; it also investigated their attitudes and interest in OE and in a structured educational service within a farm. To achieve such an aim, a literature study about OE and the educational initiatives within the farm in Italy was carried out. This was followed by an online questionnaire, carried out with 510 resident of a region of Italy (Umbria). The findings indicate high interest in educational services organized in both nature and farms. The statistical and econometric analysis of a subsample of 161 respondents having children under 6 years old has underlined that the attitudes towards OE are affected by specific socio-demographic variables: income and educational levels. In this respect, older participants having a high degree of education and benefiting from a high economic status showed the highest level of preference for OE services. In the conclusions, we underline that developing educational services "Agriasili" and "Agrinidi" can contribute to strengthening the synergy between agriculture and the education sector. They carry out social functions for the creation of collective well-being. They represent a diversification of farm business and a response to citizens' needs for early childhood education in nature; moreover, they push implementation of policies encouraging the birth of these services in rural and peri-urban areas where they are lacking or crowded.
Hyperspectral lidar for monitoring high-resolution activity patterns of African stingless bee species
Authors: Månefjord Hampus , Huzortey A. Andrew , Boateng Rabbi , Gbogbo Y. Adolphe , Yamoa A. S. Doria , Zoueu Jérémie T. , Kwapong Peter K. , Anderson Benjamin , Brydegaard Mikkel 
Published: May 2024

Abstract
Background
Stingless bees are vital pollinators and honey producers in the tropics. Research on stingless bees is generally underrepresented compared to the western honeybees, and while stingless bee studies from some regions are reported, there is a particular lack of reports on the species endemic to Sub-Saharan Africa. Since conventional entomological methods such as mark-recapture and radar harmonic tags suffer from limited observation counts and amount to a significant payload, fluorescent powder tagging offers a promising alternative to understanding their behavior. We deploy a hyperspectral fluorescence lidar monitors a 25-mm-wide transect in front of the hives.

Results
During a 1 day study at the International Stingless Bee Center, near Kakum National Park, Ghana, 17,862 insects were observed with the lidar, of which 7520 were tagged with fluorescent dyes. Approximately half of the bees from the selected hives were successfully tagged, with an estimated misclassification of 1%. According to our limited data, the observed species, Meliponula bocandei and the Dactylurina staudingeri exhibited different activity patterns. D. staudingeri displayed a half-hour longer active day, with clear crepuscular activity peaks. In contrast, M. bocandei activity was diurnal, with less pronounced crepuscular peaks.

Conclusions
We demonstrate how hyperspectral fluorescence lidar can monitor powder-tagged insects throughout the day. The monitored species revealed distinct activity patterns over the day. Our findings highlight the potential of this technology as a valuable tool for understanding insect behavior and environmental preferences of species, in situ, which could potentially give clues of response to climate changes of these critical species.
Incarceration history and opioid use among adults living with HIV and chronic pain: a secondary analysis of a prospective cohort study
Authors: Lichtiger Anna B. , Deng Yuting , Zhang Chenshu , Groeger Justina , Perez Hector R. , Nangia Gayatri , Prinz Melanie , Richard Emma , Glenn Matthew , De La Cruz Ana Alicia , Pazmino Ariana , Cunningham Chinazo O. , Amico K Rivet , Fox Aaron , Starrels Joanna L. 
Published: May 2024

Abstract
Background
Adults living with HIV have disproportionately high chronic pain, prescription opioid use, history of substance use, and incarceration. While incarceration can have long-lasting health impacts, prior studies have not examined whether distant (>1 year prior) incarceration is associated with opioid use for chronic pain, or with opioid misuse or opioid use disorder among people living with HIV and chronic pain.

Methods
We conducted a secondary analysis of a prospective cohort study of adults living with HIV and chronic pain. The independent variables were any distant incarceration and drug-related distant incarceration (both dichotomous). Dependent variables were current long-term opioid therapy, current opioid misuse, and current opioid use disorder. A series of multivariate logistic regression models were conducted, adjusting for covariates.

Results
In a cohort of 148 participants, neither distant incarceration nor drug-related incarceration history were associated with current long-term opioid therapy. Distant incarceration was associated with current opioid misuse (AOR 3.28; 95% CI: 1.41-7.61) and current opioid use disorder (AOR 4.40; 95% CI: 1.54-12.56). Drug-related incarceration history was also associated with current opioid misuse (AOR 4.31; 95% CI: 1.53-12.17) and current opioid use disorder (AOR 7.28; 95% CI: 2.06-25.71).

Conclusions
The positive associations of distant incarceration with current opioid misuse and current opioid use disorder could indicate a persistent relationship between incarceration and substance use in people living with HIV and chronic pain. Additional research on opioid use among formerly incarcerated individuals in chronic pain treatment is needed.
Emotional risk factors before in vitro fertilization among infertile couples in daily clinical practice in Sari in 2020–2022
Authors: Kargar Sommayeh Taghaddosi , Vakili Fatemeh , Peivandi Sepideh , Jahanfar Shayesteh , Elyasi Forouzan , Hamzehgardeshi Zeinab 
Published: May 2024

Abstract
Background and Aim
The relationship between psychological factors and treatment outcomes with assisted reproductive technology has sparked considerable debate. This study aims to investigate the emotional risk factors in couples seeking infertility treatment using assisted reproductive technology in Sari, Iran, from 2020 to 2022.

Materials and methods
This research is a cross-sectional study and emotional risk factors and other related factors were examined using the Persian version of the SCREENIVF demographic, social, and clinical status questionnaire, social, and clinical status questionnaire before using Assisted reproductive technology in 460 infertile couples selected from infertility treatment centers in Sari City, Iran. The samples were randomly selected using a table of random numbers. Data analysis was performed using SPSS version 22 software.

Results
The mean age of the male and female participants were 31.70 ± 5.71 and 35.22 ± 5.48, respectively. The results regarding emotional risk factors and other related factors revealed that the variables of remarriage (P = 0.048) and exposure of spouse to emotional risk factors (P = 0.001), history of depression disorder (P = 0.007), and history of anxiety disorder (P = 0.009) were significantly correlated with the exposure of women to emotional risk factors. Furthermore, men’s exposure to emotional risk factors was significantly correlated with primary education (P = 0.026) and diploma (P = 0.043) levels, age (P = 0.006), and wife’s exposure to emotional risk factors (P = 0.001).

Conclusion
By identifying infertile couples who are at risk of emotional risk factors, healthcare professionals can provide appropriate support and interventions to mitigate the emotional challenges associated with infertility. This proactive approach can significantly enhance couples undergoing infertility treatment’s well-being and mental health.
Exploring the interplay between vocational competence and dropout intention: insights and perspectives
Authors: Ma Beifang , Krötz Maximilian , Deutscher Viola , Winther Esther 
Published: May 2024

AbstractHigh drop-out rates from Vocational Education and Training (VET) remain a severe problem in VET systems globally. Despite decades of drop-out research revealing numerous influencing factors, the role of trainees’ vocational competence in their drop-out behavior has been neglected. This study aims to define the structure of vocational competence and analyze its effects on drop-out intention. Using longitudinal data from 458 commercial trainees in Germany, vocational competence is measured at three time points using a validated competence test, subdivided into domain-linked and domain-specific dimensions (Gelman and Greeno, 1989). Four different directions of drop-out intentions are considered, enabling a detailed effect inspection of the prevailing research gap. Additionally, factors identified in previous studies, such as educational level, age, language, and the degree of having chosen one’s desired occupation, are controlled for. We conducted 12 rounds of ordinal logistic regression to test three lagged temporal combinations of the effect relationship between vocational competence and dropout intention over different time spans (T0- > T1, T1- > T2, T0- > T2). We find that lower domain-specific competence increases the intention to drop out from VET without qualification over different time spans. Initial lower domain-specific competence also affects trainees’ intention to change their occupation in the final year of training. Furthermore, higher levels of domain-linked competence at the beginning increase the intention to leave VET to pursue higher qualifications in the midterm of training.
Axonal autophagic vesicle transport in the rat optic nerve in vivo under normal conditions and during acute axonal degeneration
Authors: Luo Xiaoyue , Zhang Jiong , Tolö Johan , Kügler Sebastian , Michel Uwe , Bähr Mathias , Koch Jan Christoph 
Published: May 2024

AbstractNeurons pose a particular challenge to degradative processes like autophagy due to their long and thin processes. Autophagic vesicles (AVs) are formed at the tip of the axon and transported back to the soma. This transport is essential since the final degradation of the vesicular content occurs only close to or in the soma. Here, we established an in vivo live-imaging model in the rat optic nerve using viral vector mediated LC3-labeling and two-photon-microscopy to analyze axonal transport of AVs. Under basal conditions in vivo, 50% of the AVs are moving with a majority of 85% being transported in the retrograde direction. Transport velocity is higher in the retrograde than in the anterograde direction. A crush lesion of the optic nerve results in a rapid breakdown of retrograde axonal transport while the anterograde transport stays intact over several hours. Close to the lesion site, the formation of AVs is upregulated within the first 6 h after crush, but the clearance of AVs and the levels of lysosomal markers in the adjacent axon are reduced. Expression of p150Glued, an adaptor protein of dynein, is significantly reduced after crush lesion. In vitro, fusion and colocalization of the lysosomal marker cathepsin D with AVs are reduced after axotomy. Taken together, we present here the first in vivo analysis of axonal AV transport in the mammalian CNS using live-imaging. We find that axotomy leads to severe defects of retrograde motility and a decreased clearance of AVs via the lysosomal system.
Human-land relationship in the construction of historical settlements based on Complex Adaptive System (CAS) theory: evidence from Shawan in Guangfu region, China
Authors: Zhang Yang , He Yi 
Published: May 2024

Abstract
The relationship between humans and land environment within historical settlements reflects the intricate interplay between human societies, their construction activities, and the specific geographical contexts. Inadequate research into this relationship hinders a comprehensive understanding of the social spatial intricacies inherent in historical settlements. This paper adopts the theoretical framework of complex adaptive system and takes Shawan Ancient Town in Guangfu area of China as an example. Under the geographical background of sustainable land growth in the coastal zone, this study analyzed the subtle changes in the relationship between people and land during the historical construction, and the key findings of the investigation are threefold: (1) Land resources play a central role in the construction of human-land relationships in historical settlements. The geographical environment and social institutions serve as configuring factors in the formation and evolution of human-land relationships. These factors collectively determine the formation and evolution of human-land relationships. (2) Social space emerges as a pivotal manifestation of the human–environment relationship in historical settlements, transcending mere physical dimensions. Consequently, a holistic study of this relationship necessitates a comprehensive exploration not only of spatial configurations but also of the intricate interconnections among social bonds, structural formations, societal order, and settlement spatiality. (3) Drawing on the framework of complex adaptive systems theory, the study disentangles intricate elements within the human-land relationship of historical settlements. It distills and examines the manifestations of four intricate adaptive capacities—namely aggregation, non-linearity, flow, and diversity—alongside the mechanisms of tags, internal models, and fundamental building blocks. It is believed that the study of historical settlements in coastal areas needs to grasp the invariable social-spatial objects such as geographical environment, land form, local beliefs. Take it as a clue to sort out how other elements of change have iterated and transformed in the process of historical evolution, such as the rise and fall of families, land ownership changes and social class evolution. This paper explores the value connotation of historical settlements from the perspective of dialectic thinking of change and invariance with CAS theory, which has theoretical significance for protection of settlement's human-land relationship from the perspective of "social-spatial".
Definition of a thermal conductivity map for geothermal purposes
Authors: García-Noval Carlota , Álvarez Rodrigo , García-Cortés Silverio , García Carmen , Alberquilla Fernando , Ordóñez Almudena 
Published: May 2024

AbstractThe use of geothermal energy is spreading globally due to its many advantages, especially for heating and cooling. The correct design of a geothermal system requires knowledge of the parameters of the subsoil rocks, and particularly the thermal conductivity (k), which is the intrinsic ability of a material to transfer thermal energy as a result of a temperature gradient. A thermal conductivity map of the geological formations is time-consuming to produce, but can be of great help when selecting the location of a low-enthalpy geothermal installation, resulting in significant savings and an increase in the efficiency of that installation. The preferred option for determining k is an in situ thermal response test, but laboratory methods may be an alternative if it is not available or affordable. In this work, the needle thermal probe method has been used to measure the k of representative outcropping rocks in Oviedo (NW Spain), since it allows to obtain a rapid determination, its cost is comparatively low and it can be implemented in a portable device. 162 measurements have been carried out on a total of 27 samples, ranging from 0.2 (clay) to 5.4 W m−1 K−1 (quartzite). A relationship has been found between the k of the rocks and their characteristics, such as mineralogy, anisotropy or geological age and a thermal conductivity map was created.
SERS biosensors for liquid biopsy towards cancer diagnosis by detection of various circulating biomarkers: current progress and perspectives
Authors: Lyu Nana , Hassanzadeh-Barforoushi Amin , Rey Gomez Laura M. , Zhang Wei , Wang Yuling 
Published: May 2024

AbstractLiquid biopsy has emerged as a promising non-invasive strategy for cancer diagnosis, enabling the detection of various circulating biomarkers, including circulating tumor cells (CTCs), circulating tumor nucleic acids (ctNAs), circulating tumor-derived small extracellular vesicles (sEVs), and circulating proteins. Surface-enhanced Raman scattering (SERS) biosensors have revolutionized liquid biopsy by offering sensitive and specific detection methodologies for these biomarkers. This review comprehensively examines the application of SERS-based biosensors for identification and analysis of various circulating biomarkers including CTCs, ctNAs, sEVs and proteins in liquid biopsy for cancer diagnosis. The discussion encompasses a diverse range of SERS biosensor platforms, including label-free SERS assay, magnetic bead-based SERS assay, microfluidic device-based SERS system, and paper-based SERS assay, each demonstrating unique capabilities in enhancing the sensitivity and specificity for detection of liquid biopsy cancer biomarkers. This review critically assesses the strengths, limitations, and future directions of SERS biosensors in liquid biopsy for cancer diagnosis.
An international phantom study of inter-site variability in Technetium-99m image quantification: analyses from the TARGET radioembolization study
Authors: Keane Grace , van Rooij Rob , Lam Marnix , Kappadath S. Cheenu , Kovan Bilal , Leon Stephanie , Dreher Matthew , Fowers Kirk , de Jong Hugo 
Published: May 2024

Abstract
Background
Personalised multi-compartment dosimetry based on [99mTc]Tc-MAA is a valuable tool for planning 90Y radioembolization treatments. The establishment and effective application of dose–effect relationships in yttrium-90 (90Y) radioembolization requires [99mTc]Tc-MAA SPECT quantification ideally independent of clinical site. The purpose of this multi-centre phantom study was to evaluate inter-site variability of [99mTc]Tc-MAA imaging and evaluate a standardised imaging protocol. Data was obtained from the TARGET study, an international, retrospective multi-centre study including 14 sites across 8 countries. The impact of imaging related factors was estimated using a NEMA IQ phantom (representing the liver), and a uniformly filled cylindrical phantom (representing the lungs). Imaging was performed using site-specific protocols and a standardized protocol. In addition, the impact of implementing key image corrections (scatter and attenuation correction) in the site-specific protocols was investigated. Inter-site dosimetry accuracy was evaluated by comparing computed Lung Shunt Fraction (LSF) measured using planar imaging of the cylindrical and NEMA phantom, and contrast recovery coefficient (CRC) measured using SPECT imaging of the NEMA IQ phantom.

Results
Regarding the LSF, inter-site variation with planar site-specific protocols was minimal, as determined by comparing computed LSF between sites (interquartile range 9.6–10.1%). A standardised protocol did not improve variation (interquartile range 8.4–9.0%) but did improve mean accuracy compared to the site-specific protocols (5.0% error for standardised protocol vs 8.8% error for site-specific protocols). Regarding the CRC, inter-system variation was notable for site-specific SPECT protocols and could not be improved by the standardised protocol (CRC interquartile range for 37 mm sphere 0.5–0.7 and 0.6–0.8 respectively), however the standardised protocol did improve accuracy of sphere:background determination. Implementation of key image corrections did improve inter-site variation (CRC interquartile range for 37 mm sphere 0.6–0.7).

Conclusion
Eliminating sources of variability in image corrections between imaging protocols reduces inter-site variation in quantification. A standardised protocol was not able to improve consistency of LSF or CRC but was able to improve accuracy.
Electroacupuncture attenuates neuropathic pain via suppressing BIP-IRE-1α-mediated endoplasmic reticulum stress in the anterior cingulate cortex
Authors: Ma Lin-Wei , Liu Yu-Fan , Zhang Hui , Huang Chang-Jun , Li Ang , Qu Xin-Zhe , Lin Jia-Piao , Yang Yan , Yao Yong-Xing 
Published: May 2024

AbstractStudies have suggested that endoplasmic reticulum stress (ERS) is involved in neurological dysfunction and that electroacupuncture (EA) attenuates neuropathic pain (NP) via undefined pathways. However, the role of ERS in the anterior cingulate cortex (ACC) in NP and the effect of EA on ERS in the ACC have not yet been investigated. In this study, an NP model was established by chronic constriction injury (CCI) of the left sciatic nerve in rats, and mechanical and cold tests were used to evaluate behavioral hyperalgesia. The protein expression and distribution were evaluated using western blotting and immunofluorescence. The results showed that glucose-regulated protein 78 (BIP) and inositol-requiring enzyme 1α (IRE-1α) were co-localized in neurons in the ACC. After CCI, BIP, IRE-1α, and phosphorylation of IRE-1α were upregulated in the ACC. Intra-ACC administration of 4-PBA and Kira-6 attenuated pain hypersensitivity and downregulated phosphorylation of IRE-1α, while intraperitoneal injection of 4-PBA attenuated hyperalgesia and inhibited the activation of P38 and JNK in ACC. In contrast, ERS activation by intraperitoneal injection of tunicamycin induced behavioral hyperalgesia in naive rats. Furthermore, EA attenuated pain hypersensitivity and inhibited the CCI-induced overexpression of BIP and pIRE-1α. Taken together, these results demonstrate that EA attenuates NP by suppressing BIP- and IRE-1α-mediated ERS in the ACC. Our study presents novel evidence that ERS in the ACC is implicated in the development of NP and provides insights into the molecular mechanisms involved in the analgesic effect of EA.