bluuebunny/crossref_metadata_2025_split huggingface dataset:
Differentiated adipose‐derived stem cells promote myelination and enhance functional recovery in a rat model of chronic denervation
Authors: Tomita Koichi , Madura Tomas , Mantovani Cristina , Terenghi Giorgio 
Published: March 2012

AbstractTransplantation of autologous Schwann cells (SCs) is a promising approach for treating various peripheral nerve disorders, including chronic denervation. However, given their drawbacks, such as invasive biopsy and lengthy culture in vitro, alternative cell sources would be needed. Adipose‐derived stem cells (ASCs) are a candidate, and in this study rat ASCs transdifferentiated into a SC phenotype (dASC) cocultured with dorsal root ganglion neurons were shown to associate with neurites and to express myelin basic protein (MBP)‐positive myelin protein. Furthermore, dASCs transplanted into a chronically denervated rat common peroneal nerve survived for at least for 10 weeks, maintaining their differentiated state. Immunohistochemical analysis revealed that transplanted dASCs associated with regenerating axons, forming MBP‐/protein zero‐positive myelin sheaths. The cell survival and myelin expression assessed by double labelling with S100 and glial fibrillary acidic protein were similar between the dASC‐ and SC‐transplanted nerves. Importantly, transplantation of dASCs resulted in dramatically improved motor functional recovery and nerve regeneration, with a level comparable to, or even superior to, transplantation of SCs. In conclusion, dASCs are capable of myelinating axons in vivo and enhancing functional outcome after chronic denervation. © 2012 Wiley Periodicals, Inc.
Increased aquaporin‐1 and Na+‐K+‐2Cl– cotransporter 1 expression in choroid plexus leads to blood–cerebrospinal fluid barrier disruption and necrosis of hippocampal CA1 cells in acute rat models of hyponatremia
Authors: Kim Jaehyun , Jung Yongwook 
Published: March 2012

AbstractHyponatremia is a metabolic disorder characterized by increased cerebrospinal fluid (CSF) volume and pressure, although the site of brain insult is unclear. Specifically, the hippocampus, which is in direct contact with expanding CSF ventricles, may be involved. The present study was undertaken to investigate the possible roles of choroid plexus aquaporin‐1 (AQP1) and of cation chloride transporters (Na+‐K+‐2Cl– cotransporter 1 [NKCC1] and K+‐Cl– cotransporter 4 [KCC4]) in the underlying hippocampal pathophysiology of hyponatremia in acute (6 and 12 hr duration) experimental models. It was found that the expressions of AQP1 and NKCC1 proteins in choroid plexus were significantly increased, whereas the expression of KCC4 protein was unchanged vs. control values after 6 and 12 hr of hyponatremia. Choroid plexuses with increased AQP1 and NKCC1 after 6 hr of hyponatremia showed caspase 3‐dependent apoptosis and disruption of the blood–CSF barrier. Furthermore, necrotic changes in CA1 neuronal cells were observed after 6 and 12 hr of hyponatremia. Overall, these data suggest that increases in AQP1 and NKCC1 expression under hyposmotic stress may be one of the molecular mechanisms underlying the pathophysiology of acute hyponatremia, such as the necrotic cell death of hippocampal CA1 region by increasing water transport across the blood–CSF barrier. Furthermore, we suggest that opening of the blood–CSF barrier after acute hyponatremia may be triggered the secondary adverse conditions that are capable of enhancing selective necrosis in hippocampal CA1 cells. © 2012 Wiley Periodicals, Inc.
Ectopic expression of TrKA in the adult rat basal ganglia induces both nerve growth factor‐dependent and ‐independent neuronal responses
Authors: Giannakopoulou Dimitra , Daguin‐Nerrière Véronique , Mitsacos Adamantia , Kouvelas Elias D. , Neveu Isabelle , Giompres Panagiotis , Brachet Philippe 
Published: March 2012

AbstractEctopic expression of tropomyosin‐related kinase A (TrkA), the high‐affinity receptor of nerve growth factor (NGF), has been widely used in cell culture systems to uncover its role in cell survival or death events. In contrast, little is known about the consequences of its expression in vivo. To address this question, adeno‐associated virus (AAV) vectors were used to express TrkA in the substantia nigra (SN) and striatum of adult rats. Nine weeks after transfer, tyrosine hydroxylase (TH) and dopamine transporter (DAT) mRNAs were slightly decreased in the ipsilateral SN. This decrease was no longer significant when NGF was delivered into the striatum. There was no change of DAT binding sites or D1 or D2 receptor mRNAs and binding sites in the striatum, suggesting that ectopic TrkA exerts a limited effect on the pool of TH and DAT transcripts, without affecting overall dopamine signaling. When transferred into the striatum, TrkA transgene had no effect on the size of the cholinergic interneurons, but it exerted typical neurotrophic effects, as shown by an enlargement of the projection neurons and nitric oxide synthase (nNOS)‐expressing interneurons. This trophic action was amplified by a delivery of NGF. No toxic effect of the transgene was noted. These data indicate that ectopic expression of TrkA may result in the promotion of neurotrophic effects or can influence neuronal plasticity in the absence of exogenous NGF in neuronal populations that naturally fail to respond to this factor. © 2012 Wiley Periodicals, Inc.
Expression of estrogen receptors in gastric cancer and their clinical significance
Authors: Ryu Woo‐Sang , Kim Jong‐Han , Jang You‐Jin , Park Sung‐Soo , Um Jun‐Won , Park Seong‐Heum , Kim Seung‐Joo , Mok Young‐Jae , Kim Chong‐Suk 
Published: March 2012

AbstractBackgrounds and ObjectivesThe male predominance of gastric cancer suggests that female sex hormones may have a protective effect against gastric cancer. We evaluated the expression of estrogen receptors in gastric cancer tissue and cells and the clinical significance of ER‐β expression in gastric cancer.MethodER‐α, ER‐β proteins extracted from normal stomach, gastric cancer tissues, and cultured gastric cancer cells (KATO‐III, mkn28, mkn45, and mkn74) were assessed by Western blot analysis. The clinical significance of ER‐β was explored using tissue microarray methods and immunohistochemical staining of specimens from 148 gastric cancers.ResultsBoth ER‐α and β protein expression were noted in normal and gastric cancer tissues. However, in cultured gastric cells, only ER‐β was noted in mkn28 and mkn74. Of 148 gastric cancers, 67 (45.3%) were ER‐β positive. The ER‐β positive group was associated with lower tumor stage, Lauren's intestinal type, negative perineural invasion, and free of recurrence. The ER‐β positive group had a better 3‐year survival compared with the negative group in survival analysis.ConclusionOur results suggest that the presence of ER‐β in gastric cancer could have a protective effect against invasiveness of gastric cancer. Further studies are needed to clarify the role of ER‐β in gastric cancers. J. Surg. Oncol. 2012; 106:456–461. © 2012 Wiley Periodicals, Inc.
Comparative study of the tribological properties of ionic liquids as additives of the attapulgite and bentone greases
Authors: Wang Zeyun , Xia Yanqiu , Liu Zhilu 
Published: March 2012

ABSTRACTThree kinds of ionic liquids (1‐butyl‐3‐methylimidazolium hexafluorophosphate (L‐P104), 1‐hexyl‐3‐methyl imidazolium hexafluorophosphate (L‐P106) and 1‐octyl‐3‐methylimidazolium tetrafluoroborate (LB108)) were added to the attapulgite base grease and the bentone base grease to investigate and compare the tribological behaviours of the ionic liquids with the two base greases at room temperature and 150°C. Tribological tests were performed using a ball‐on‐plate reciprocating tribometer. The attapulgite base grease showed better wear resistance properties than that of bentone base grease by adding ionic liquids as additives. At same time, the attapulgite base grease showed excellent friction‐reducing and wear resistance properties at high temperature (150°C). Also, we discussed the tribological mechanism of the attapulgite base grease at both room temperature and 150°C from the aspect of the structure of the grease thicker. Copyright © 2012 John Wiley & Sons, Ltd.
Galling resistance evaluation of tool steels by two different laboratory test methods for sheet metal forming
Authors: Karlsson P. , Eriksson J. , Gåård A. , Krakhmalev P. , Olsson M. , Bergström J. 
Published: March 2012

ABSTRACTAdhesive accumulation of work material on the tool surface is today a major problem in many sheet metal‐forming applications. Different laboratory test methods are used to investigate galling with respect to different tool materials, lubricants and process conditions. In the present study, the galling resistance of a modern nitrogen‐alloyed powder metallurgy tool steel and an conventional ingot cast D2 type tool steel was evaluated under lubricated sliding against ferritic stainless steel sheets using a commercial pin‐on‐disc (POD) and an in‐house made slider‐on‐flat‐surface (SOFS) tribotester. The investigated tool steels ranked similarly in terms of galling resistanc in both test methods. However, sliding distances to galling were longer for the SOFS equipment due to continuous sliding on new lubricated sheet surface. Best performance was demonstrated by the powder metallurgy tool steel treated to 65 HRC. Differences in friction behaviour and galling initiation were analysed on the basis of the two different working conditions, i.e. open (SOFS) and closed (POD) tribosystems. Copyright © 2012 John Wiley & Sons, Ltd.
Genetic Risk and Outcome of Psychosis (GROUP), a multi site longitudinal cohort study focused on gene–environment interaction: objectives, sample characteristics, recruitment and assessment methods
Authors: Korver Nikie , Quee Piotr J. , Boos Heleen B. M. , Simons Claudia J. P. , de Haan Lieuwe ,   GROUP investigators
Published: March 2012

AbstractObjectiveA longitudinal focus on gene–environment vulnerability and resilience in both patients, their unaffected family members and non‐related controls offers the opportunity to elucidate etiological and pathogenetic factors influencing the onset and course of psychotic disorders. The current paper delineates the objectives, sample characteristics, recruitment and assessment procedures of the Genetic Risk and Outcome of Psychoses (GROUP) study.MethodsA naturalistic longitudinal cohort study with assessments at baseline, after three and six years of follow‐up. The study is conducted by a consortium of four university psychiatric centres, with their affiliated mental health care institutions in the Netherlands covering more than 7.5 million inhabitants. Extensive assessment of genetic factors, environmental factors, (endo)phenotypes, and outcome.ResultsAt baseline, 1120 patients, 1057 siblings, 919 parents and 590 healthy controls were included.ConclusionThe GROUP study will contribute to insight in risk and protective factors in the aetiology of non‐affective psychotic disorders, and in the variation in their course and outcome. Copyright © 2012 John Wiley & Sons, Ltd.
Mental adjustment at different phases in breast cancer trajectory: re‐examination of factor structure of the Mini‐MAC and its correlation with distress
Authors: Wang Wei‐Ting , Tu Pei‐Chiung , Liu Tse‐Jia , Yeh Dah‐Cherng , Hsu Wen‐Yau 
Published: March 2012

AbstractObjectiveThe aim of this study is twofold. First, it aims to determine the factor structure of the Mini‐Mental Adjustment to Cancer (Mini‐MAC) Scale by using confirmatory factor analysis (CFA) to compare the three‐factor, four‐factor, and five‐factor structures among 340 Taiwanese breast cancer patients. Second, it aims to test the difference in the correlations of coping strategies and the outcome measures between two populations: one‐month newly diagnosed and five‐year long‐term survival patients.MethodsTwo samples, composed of 142 newly diagnosed and 198 long‐term survival breast cancer patients, were recruited. Cancer‐specific coping and distress were assessed via the Mini‐MAC Scale and the Hospital Anxiety and Depression Scale (HADS), respectively.ResultsThe CFA confirmed Watson's original five‐factor structure fit the data best. The correlation difference between the two samples lies in the fighting spirit (FS), which correlated negatively with distress among the newly diagnosed sample but had no correlation among the long‐term survivors. Moreover, fatalism (FA) was found to correlate positively with distress.ConclusionsThe five‐factor structure represents a more psychometrically sound measure of psychological adjustment in the current data set. The findings also support the argument that the relationships between coping and distress vary, to some degree, at different phases in the cancer trajectory. FS is only a positive predictor of psychological adjustment among newly diagnosed patients. Because of the exclusion of two items, FA showed a positive correlation with distress, a result that contradicts previous findings. Further theoretical and practical implications for FS and FA are discussed.Copyright © 2012 John Wiley & Sons, Ltd.
Interpreting differences in patterns of supportive care needs between patients with breast cancer and patients with colorectal cancer
Authors: Li Wylie W. Y. , Lam Wendy W. T. , Au Angel H. Y. , Ye Michelle , Law Wai Lun , Poon Jensen , Kwong Ava , Suen Dacita , Tsang Janice , Girgis Afaf , Fielding Richard 
Published: March 2012

AbstractBackgroundUnderstanding cancer patients' supportive care needs can help optimize health‐care systems and inform services development. We therefore examined the prevalence of supportive care needs in Chinese breast (BC) and colorectal cancer (CRC) patients to identify prevalence and correlates of unmet needs.MethodsWe assessed supportive care needs (Supportive Care Needs Survey—Short Form), psychological distress (the Hospital Anxiety and Depression Scale), symptom distress (The Memorial Symptom Assessment Scale—Short Form), and satisfaction with care (Patient Satisfaction Questionnaire) among 210 Chinese BC (97) or CRC (104) outpatient clinic attendees.ResultsBreast cancer patients (89.7%) reported more unmet needs (χ2 = 4.409, p = 0.027), but both CRC and BC samples ranked unmet needs prevalence similarly, with health system and information needs reported as the most common. Younger patients reported higher health system and information and sexuality needs. After multivariate adjustment, the strength of unmet needs did not differ by cancer type. Unmet psychological, physical and daily living, and sexuality needs were positively associated with greater symptom distress. Greater health system information needs were associated with high global distress and low depression scores, whereas greater psychological needs were associated with higher anxiety scores.ConclusionsHong Kong Chinese BC and CRC patients strongly prioritized needs related to health systems and information provision. Symptoms and psychological distress were associated with unmet needs, reflecting a service shortfall in symptom management. Improving care provision by optimizing communication and clinic organization can better prepare cancer patients for their rehabilitation and improve symptom control. Copyright © 2012 John Wiley & Sons, Ltd.
Unravelling the genetic bases of non‐target‐site‐based resistance (NTSR) to herbicides: a major challenge for weed science in the forthcoming decade
Authors: Délye Christophe 
Published: March 2012

AbstractNon‐target‐site‐based resistance (NTSR) can confer unpredictable cross‐resistance to herbicides. However, the genetic determinants of NTSR remain poorly known. The current, urgent challenge for weed scientists is thus to elucidate the bases of NTSR so that detection tools are developed, the evolution of NTSR is understood, the efficacy of the shrinking herbicide portfolio is maintained and integrated weed management strategies, including fully effective herbicide applications, are designed and implemented. In this paper, the importance of NTSR in resistance to herbicides is underlined. The most likely way in which NTSR evolves—by accumulation of different mechanisms within individual plants—is described. The NTSR mechanisms, which can interfere with herbicide penetration, translocation and accumulation at the target site, and/or protect the plant against the consequences of herbicide action, are then reviewed. NTSR is a part of the plant stress response. As such, NTSR is a dynamic process unrolling over time that involves ‘protectors’ directly interfering with herbicide action, and also regulators controlling ‘protector’ expression. NTSR is thus a quantitative trait. On this basis, a three‐step procedure is proposed, based on the use of the ‘omics’ (genomics, transcriptomics, proteomics or metabolomics), to unravel the genetic bases of NTSR. Copyright © 2012 Society of Chemical Industry
Syntheses and properties of new metal complexes based on TTF‐ligands with multidentate coordination sites
Authors: Nishikawa Hiroyuki , Kitabatake Ryosuke , Mitsumoto Kiyotaka , Oshio Hiroki 
Published: March 2012

AbstractSeveral TTF‐ligands with Schiff‐base type coordination sites have been synthesized to develop new TTF‐based metal complexes: tetradentate H2bsae‐TTF [4,5‐bis(2‐salycylideneiminoethylthio)‐TTF] and hexadentate macrocyclic‐TTF. Both ligands yielded mononuclear metal complexes, [CuII(bsae‐TTF)] and [MII(macrocyclic‐TTF)](BF4)2 (MII = FeII, CoII, NiII, ZnII). Electrochemical measurements revealed that both the bsae‐TTF and macrocyclic‐TTF complexes retained the redox properties of TTF moieties. All the metal complexes with macrocyclic‐TTF ligand were isostructural octahedral coordination structure. Among them, Co(II) complex showed spin‐crossover behaviour above room temperature. (© 2012 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Magnetic properties of [K(18‐crown‐6)][Ni(α‐tpdt)2]
Authors: Belo Dulce , Neves Ana I. S. , Pereira L. C. J. , Almeida Manuel 
Published: March 2012

AbstractA new salt based on the [Ni(α‐tpdt)2]‐ anion, (α‐tpdt=2,3‐thiophenedithiolate) and on the K+ crown‐ether cation [K(18‐crown‐6)]+ is magnetically characterized. This salt exhibits interesting magnetic properties resulting from the spin polarization within the anionic molecule and from the specific molecular interactions arrangement in the crystal structure. Therefore the magnetic properties are due to the competition between AFM and FM interactions leading, at low temperature, to a cluster glass behaviour that is also associated with the ligand cis‐trans disorder. (© 2012 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Structure and properties of semisquarate‐substituted TTF derivatives and their radical ion salts
Authors: Miyazaki Akira , Ono Satoshi , Yamazaki Miki 
Published: March 2012

AbstractSynthesis, characterization and physical properties of two semisquarate‐substituted TTF derivatives, Me2TTFsqiPr and Me3TTFsqiPr and their radical salts are reported. Both molecules show solvatochromism as observed similarly in TTFsqiPr, showing the zwitterionic character of their photoexcited states. The maximum wavelength of the intra‐molecular charge‐transfer transition (λmax), and the two‐step redox potentials correlate to the number of electron‐donating methyl groups introduced in the TTF unit. These molecules form columnar structures in their neutral crystals and face‐to‐face dimer structures in radical ion salts Men TTFsqiPr•FeCl4 (n = 2, 3). The magnetic Fe spins in Me3TTFsqiPr•FeCl4 salt is antiferromagnetically coupled with the donor dimer units by means of superexchange interaction. The structure of TTFsqiPr•GaCl4 is characterized with mutually‐orthogonal donor and anion helices. The small magnetism in TTFsqiPr•FeCl4 suggests the antiferromagnetic coupling of donor and anion magnetic chains via intermolecular contacts. (© 2012 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Magnetic heat capacities of κ ‐(BETS)2FeBr4 measured by a micro‐chip calorimeter
Authors: Fukuoka Shuhei , Yamashita Satoshi , Yamamoto Takashi , Nakazawa Yasuhiro , Kobayashi Akiko , Kobayashi Hayao 
Published: March 2012

AbstractLow temperature thermodynamic properties of κ ‐(BETS)2FeBr4 are studied by using a tiny single crystal sample with 1 µg adhered on a micro‐chip calorimeter TCG3880. A large thermal anomaly associated with the antiferromagnetic transition of localized d electrons of Fe3+ was observed around 2.2 K. With the increase of magnetic fields applied parallel to the ac plane, the transition temperature shifts to lower temperature side accompanied by an anisotropic character. We found that the reduction of the transition temperature is largest, when magnetic field was applied parallel to a‐axis. This observation is consistent with the previous result obtained by transport measurements which claimed that the spin easy axis is a‐axis. The results demonstrate that the microchip calorimeter is effective for conducting thermodynamic measurements of molecular compounds. (© 2012 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Field‐induced length changes in the spin‐liquid candidate κ‐(BEDT‐TTF)2Cu2(CN)3
Authors: Manna Rudra Sekhar , de Souza Mariano , Schlueter John A. , Lang Michael 
Published: March 2012

AbstractMeasurements of the coefficient of thermal expansion on the spin‐liquid candidate κ‐(BEDT‐TTF)2Cu2(CN)3 have revealed distinct and strongly anisotropic lattice effects around 6 K – a possible spin liquid instability. In order to study the effects of a magnetic field on the low‐temperature spin‐liquid state, dilatometric measurements have been conducted both as a function of temperature at B = const. and as a function of field at T = const. While the 6 K anomaly is found to be insensitive to magnetic fields B ≤ 10 T, the maximum field applied, surprisingly strong B ‐induced effects are observed for magnetic fields applied along the in‐plane b‐axis. Above a threshold field of 0.5 T < Bc ≤ 1 T, a jump‐like anomaly is observed in the b‐axis lattice parameter. This anomaly, which is located at 8.7 K at B = 1 T, grows in size and shifts to lower temperatures with increasing the magnetic field. Although the anomaly bears resemblance to a first‐order phase transition, the lack of hysteresis suggests otherwise. (© 2012 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
The role of pressure in the electrical transport of doped plasticized polyanilines
Authors: Fier I. , Djurado D. , Pron A. , Travers J.‐P. , Walmsley L. 
Published: March 2012

AbstractThe behaviour of dc longitudinal and transverse conductivity in self‐assembled plastdoped films of polyaniline has been studied over the range of 9 K to 320 K, under different applied mechanical pressures. We observe a progressive evolution of the conductivity picture as the applied pressure is increased, especially in the transverse direction, where the conductivity tends to lower as the pressure is increased. (© 2012 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Magnetism in crown‐ether‐substituted nitronyl nitroxide derivatives and their metal complexes
Authors: Sugano Tadashi , Blundell Stephen J. , Hayes William , Tajima Hiroyuki , Mori Hatsumi 
Published: March 2012

AbstractRare‐earth‐metal (M = Nd, Gd and Dy) complexes of the organic monoradicals, 15‐crown‐5‐phenyl nitronyl nitroxide 1 and 15‐crown‐5‐ or 18‐crown‐6‐phenyl iminonitroxide 2, were synthesized. We present here magnetic properties of the metal‐free radicals and the metal complexes of these organic monoradicals studied using SQUID megnetometry. Almost of all the rare‐earth‐metal complexes show two‐sublattice behavior in a wide range of antiferromagnetic (AFM) intrasublattice and ferromagnetic (FM) intersublattice interactions, Γ and λ, with |CΓ | and |Cλ | ≅ 10 to 100 K (C is the Curie constant) over the temperature range between 1.8 and 300 K, while the metal‐free radicals exhibit only weak AFM intermolecular interactions, less than the Weiss constant θ = –1 K. The magnitude of interactions observed in the metal complexes of each radical increase in order from Gd to Dy to Nd complexes. (© 2012 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)