bluuebunny/crossref_metadata_2025_split huggingface dataset:
New delay‐dependent robust stability of discrete singular systems with time‐varying delay
Authors: Du Zhaoping , Zhang Qingling , Liu Lili 
Published: June 2010

AbstractThe robust stability of discrete singular systems with time‐varying delay is considered. New delay‐dependent stability criteria are proposed, which are dependent on the minimum and maximum delay bounds. A strict delay‐dependent linear matrix inequality (LMI) condition is obtained for a discrete singular time‐varying system to be regular, causal and stable. The result on robust stabilization of uncertain discrete singular time‐varying systems is also obtained and expressed in terms of LMIs. Numerical examples are given to demonstrate the applicability of the proposed method. Copyright © 2010 John Wiley and Sons Asia Pte Ltd and Chinese Automatic Control Society
A systems‐based approach to investigate dose‐ and time‐dependent methylmercury‐induced gene expression response in C57BL/6 mouse embryos undergoing neurulation
Authors: Robinson Joshua F. , Guerrette Zachariah , Yu Xiaozhong , Hong Sungwoo , Faustman Elaine M. 
Published: June 2010

AbstractBACKGROUND: Aberrations during neurulation due to genetic and/or environmental factors underlie a variety of adverse developmental outcomes, including neural tube defects (NTDs). Methylmercury (MeHg) is a developmental neurotoxicant and teratogen that perturbs a wide range of biological processes/pathways in animal models, including those involved in early gestation (e.g., cell cycle, cell differentiation). Yet, the relationship between these MeHg‐linked effects and changes in gestational development remains unresolved. Specifically, current information lacks mechanistic comparisons across dose or time for MeHg exposure during neurulation. These detailed investigations are crucial for identifying sensitive indicators of toxicity and for risk assessment applications. METHODS: Using a systems‐based toxicogenomic approach, we examined dose‐ and time‐dependent effects of MeHg on gene expression in C57BL/6 mouse embryos during cranial neural tube closure, assessing for significantly altered genes and associated Gene Ontology (GO) biological processes. Using the GO‐based application GO‐Quant, we quantitatively assessed dose‐ and time‐dependent effects on gene expression within enriched GO biological processes impacted by MeHg. RESULTS: We observed MeHg to significantly alter expression of 883 genes, including several genes (e.g., Vangl2, Celsr1, Ptk7, Twist, Tcf7) previously characterized to be crucial for neural tube development. Significantly altered genes were associated with development cell adhesion, cell cycle, and cell differentiation–related GO biological processes. CONCLUSIONS: Our results suggest that MeHg‐induced impacts within these biological processes during gestational development may underlie MeHg‐induced teratogenic and neurodevelopmental toxicity outcomes. Birth Defects Res (Part B) 89:188–200, 2010. © 2010 Wiley‐Liss, Inc.
Embryo‐fetal developmental toxicity of figitumumab, an anti‐insulin‐like growth factor‐1 receptor (IGF‐1R) monoclonal antibody, in cynomolgus monkeys
Authors: Bowman Christopher J. , Chmielewski Gary , Oneda Satoru , Finco Deborah , Boucher Mary A. , Todd Marque 
Published: June 2010

AbstractBACKGROUND: Insulin‐like growth factor (IGF) signaling has been linked to tumor cell survival and tumorigenesis. The anti‐IGF‐1 receptor monoclonal antibody, figitumumab, has been developed as an anti‐cancer therapeutic. As part of the safety evaluation, an embryo‐fetal developmental toxicity study was conducted in the cynomolgus monkey. METHODS: Figitumumab was administered once weekly intravenously at a dose of 5, 15, or 100 mg/kg during the period of major organogenesis (gestation days [GD] 20–48) with scheduled cesarean section around GD100. Maternal endpoints included clinical observations, food consumption, body weights, hematology, placental weights, toxicokinetics, and immunogenicity. Fetal evaluations included viability; body weights; external, visceral, and skeletal examination (and measurements); drug exposure; and immunogenicity. RESULTS: There was a dose‐dependent increase in embryo‐fetal loss in the presence of decreased maternal food consumption and slight reduction in body weight. Figitumumab‐related embryo‐fetal developmental toxicity was observed as growth retardation exhibited by reduced fetal body weights at all doses with corresponding developmental delays in morphology. Treatment‐related fetal structural malformations were also observed in the mid‐ and high‐dose groups. CONCLUSIONS: Maternal figitumumab dosing only during the period of organogenesis was associated with pregnancy loss and fetal growth deficits; both considered consistent with inhibition of IGF signaling. Fetal malformations were also observed, and were considered secondary to altered placental function and/or reduced fetal growth; however, direct inhibition of IGF signaling in the conceptus cannot be ruled out. This appears to be the first report of treatment‐related fetal anomalies with a monoclonal antibody when administered only during the period of major organogenesis. Birth Defects Res (Part B) 89:326–338, 2010.© 2010 Wiley‐Liss, Inc.
In silico genome‐scale metabolic analysis of Pseudomonas putida KT2440 for polyhydroxyalkanoate synthesis, degradation of aromatics and anaerobic survival
Authors: Sohn Seung Bum , Kim Tae Yong , Park Jong Myoung , Lee Sang Yup 
Published: June 2010

AbstractGenome‐scale metabolic models have been appearing with increasing frequency and have been employed in a wide range of biotechnological applications as well as in biological studies. With the metabolic model as a platform, engineering strategies have become more systematic and focused, unlike the random shotgun approach used in the past. Here we present the genome‐scale metabolic model of the versatile Gram‐negative bacterium Pseudomonas putida, which has gained widespread interest for various biotechnological applications. With the construction of the genome‐scale metabolic model of P. putida KT2440, PpuMBEL1071, we investigated various characteristics of P. putida, such as its capacity for synthesizing polyhydroxyalkanoates (PHA) and degrading aromatics. Although P. putida has been characterized as a strict aerobic bacterium, the physiological characteristics required to achieve anaerobic survival were investigated. Through analysis of PpuMBEL1071, extended survival of P. putida under anaerobic stress was achieved by introducing the ackA gene from Pseudomonas aeruginosa and Escherichia coli.
Effect of 2‐hydroxypropyl‐β‐cyclodextrin on thermal stability and aggregation of glycogen phosphorylase b from rabbit skeletal muscle
Authors: Eronina Tatyana B. , Chebotareva Natalia A. , Kleymenov Sergey Yu. , Roman Svetlana G. , Makeeva Valentina F. , Kurganov Boris I. 
Published: June 2010

AbstractThe study of the kinetics of thermal aggregation of glycogen phosphorylase b (Phb) from rabbit skeletal muscles by dynamic light scattering at 48°C showed that 2‐hydroxypropyl‐β‐cyclodextrin (HP‐β‐CD) accelerated the aggregation process and induced the formation of the larger protein aggregates. The reason of the accelerating effect of HP‐β‐CD is destabilization of the protein molecule under action of HP‐β‐CD. This conclusion was supported by the data on differential scanning calorimetry and the kinetic data on thermal inactivation of Phb. It is assumed that destabilization of the Phb molecule is due to preferential binding of HP‐β‐CD to intermediates of protein unfolding in comparison with the original native state. The conclusion regarding the ability of the native Phb for binding of HP‐β‐CD was substantiated by the data on the enzyme inhibition by HP‐β‐CD. © 2010 Wiley Periodicals, Inc. Biopolymers 93: 986–993, 2010.
Glioblastoma cancer stem cells: heterogeneity, microenvironment and related therapeutic strategies
Authors: Denysenko Tetyana , Gennero Luisa , Roos Maria Augusta , Melcarne Antonio , Juenemann Carola , Faccani Giuliano , Morra Isabella , Cavallo Giovanni , Reguzzi Stefano , Pescarmona Gianpiero , Ponzetto Antonio 
Published: June 2010

AbstractGlioblastoma Multiforme (GBM) is an incurable malignancy. GBM patients have a short life expectancy despite aggressive therapeutic approaches based on surgical resection followed by adjuvant radiotherapy and concomitant chemotherapy. Glioblastoma growth is characterized by a high motility of tumour cells, their resistance to both chemo/radio‐therapy, apoptosis inhibition leading to failure of conventional therapy. Cancer Stem Cells (CSCs), identified in GBM as well as in many other cancer types, express the membrane antigen prominin‐1 (namely CD133). These cells and normal Neural Stem Cells (NSC) share surface markers and properties, i.e. are able to self‐renew and differentiate into multiple cell types. Stem cell self‐renewal depends on microenvironmental cues, including Extracellular Matrix (ECM) composition and cell types. Therefore, the role of microenvironment needs to be evaluated to clarify its importance in tumour initiation and progression through CSCs. The specific microenvironment of CSCs was found to mimic in part the vascular niche of normal stem cells. The targeting of GMB CSCs may represent a powerful treatment approach. Lastly, in GBM patients cancer‐initiating cells contribute to the profound immune suppression that in turn correlated with CSCs STAT3 (CD133 + ). Further studies of microenvironment are needed to better understand the origin of GMB/GBM CSCs and its immunosuppressive properties. Copyright © 2010 John Wiley & Sons, Ltd.
Catalytic Polymer Membranes under Forcing Conditions: Reduction of Nitrobenzene by CO/H2O Catalyzed by Ruthenium Bis(arylimino)acenaphthene Complexes
Authors: Viganò Marta , Ragaini Fabio , Buonomenna Maria Giovanna , Lariccia Roberta , Caselli Alessandro , Gallo Emma , Cenini Sergio , Jansen Johannes Carolus , Drioli Enrico 
Published: June 2010

AbstractPolymeric membranes embedding a metal complex have been previously employed as reusable catalysts under relatively mild conditions. Herein, the first example of a polymeric catalytic membrane employed under very forcing conditions (160 °C and 5 MPa CO) is reported. The reaction investigated was the reduction of nitrobenzene to aniline by CO/H2O, catalyzed by ruthenium bis(arylimino)acenaphthene (Ar‐BIAN) complexes. To better retain the complex in the membrane, a modified ligand, with long alkyl chains in the para positions of the aryl rings, was prepared. Among several polymers tested as membranes, PEEK‐WC, a modified polyether ether ketone, gave the best results. Attempts to embed the ligand only in the membrane and functionalize it with the metal later, analogously to the in situ generation of the active species practiced for the homogeneous system, failed and it was necessary to synthesize new complexes that could be reduced under the reaction conditions. Best results were obtained using [Ru(Ar‐BIAN)(CO)2Cl2]+Et3N. During the reaction, the complex is transformed into a mixture of [Ru3(CO)12] and a reduced form of the ligand, Ar‐BIANH2. The latter was independently prepared and shown to be able to reduce nitrobenzene even in the absence of any metal. A new kind of support was designed to allow the placing of the membrane in a stirred autoclave. Using only water as solvent, no metal or ligand leaching was detected and several recycles were performed. All employed membranes were thoroughly characterized by different techniques.
Characterization of Synthetic Iron Oxides and their Performance as Support for Au Catalysts.
Authors: Centomo Paolo , Zecca Marco , Di Noto Vito , Lavina Sandra , Bombi G. Giorgio , Nodari Luca , Salviulo Gabriella , Ingoglia Roberta , Milone Candida , Galvagno Signorino , Corain Benedetto 
Published: June 2010

AbstractGold(0) catalysts supported on ferric oxide are effective catalysts, and so far, the only heterogeneous ones known for the regioselective hydrogenation of α,β‐unsaturated ketones to the corresponding α,β‐unsaturated secondary alcohols. A set of ferric oxide samples, synthesized under strictly controlled conditions and thoroughly characterized (X‐ray powder diffraction, Mössbauer spectroscopy, micro‐Raman spectroscopy, transmission electron microscopy, temperature‐programmed reduction), were employed as supports of gold(0) catalysts for this reaction. The activity and selectivity of the catalysts changed in the same direction from one catalyst to another; increasing fractions of nanostructured ferric oxide phases in the support (with nanoparticles size lower than 10 nm) increased both. With a 4 % gold catalyst supported on the ferric oxide sample containing the highest proportion of nanostructured matter, we achieved a selectivity of 66 % towards the unsaturated alcohol at more than 90 % conversion in the hydrogenation of benzalacetone (ethanol, 60 °C, 103 kPa), which is one of the best performances ever reported for this reaction.
Making MetalCarbon Nitride Heterojunctions for Improved Photocatalytic Hydrogen Evolution with Visible Light
Authors: Di Yan , Wang Xinchen , Thomas Arne , Antonietti Markus 
Published: June 2010

AbstractGold nanoparticles were deposited on the surface of a g‐C3N4 semiconductor by deposition–precipitation, photodeposition, and impregnation methods to make metal–semiconductor junctions for photocatalytic hydrogen evolution from aqueous solution containing an electron donor with visible light illumination. The samples were characterized by X‐ray diffraction (XRD), X‐ray photoelectron spectroscopy (XPS), UV/Vis, and transmission electron microscopy (TEM). Results show that the Au/g‐C3N4 prepared by the deposition–precipitation method possessed the best photocatalytic activity, due to the formation of tight Au–semiconductor heterojunctions effectively promoting the transfer of charge from light‐excited g‐C3N4. Surface modification of the Au/g‐C3N4 with a second metal further improved the activity of the photocatalytic system, which was explained by simultaneous optimization of electron transfer by the gold and chemical reactivity by the secondary metal.
Scission of Carbon Monoxide Using TaR3, R=(N(tBu)Ph) or OSi(tBu)3: A DFT Investigation
Authors: Brookes Nigel J. , Ariafard Alireza , Stranger Robert , Yates Brian F. 
Published: June 2010

AbstractThe experimentally known reduction of carbon monoxide using a 3‐coordinate [Ta(silox)3] (silox=OSi(tBu)3) complex initially forms a ketenylidene [(silox)3TaCCO], followed by a dicarbide [(silox)3TaCCTa(silox)3] structure. The mechanism for this intricate reaction has finally been revealed by using density functional theory, and importantly a likely structure for the previously unknown intermediate [(silox)3TaCO]2 has been identified. The analysis of the reaction pathway and the numerous intermediates has also uncovered an interesting pattern that results in CO cleavage, that being scission from a structure of the general form [(silox)3TaCnO] in which n is even. When n is odd, cleavage cannot occur. The mechanism has been extended to consider the effect of altering both the metal species and the ligand environment. Specifically, we predict that introducing electron‐rich metals to the right of Ta in the periodic table to create mixed‐metal dinuclear intermediates shows great promise, as does the ligand environment of the Cummins‐style 3‐coordinate amide structure. This latter environment has the added complexity of improved electron donation from amide rotation that can significantly increase the reaction exothermicity.
Lanthanide(III) Complexes of 4,10‐Bis(phosphonomethyl)‐1,4,7,10‐tetraazacyclododecane‐1,7‐diacetic acid (trans‐H6do2a2p) in Solution and in the Solid State: Structural Studies Along the Series
Authors: Campello M. Paula C. , Lacerda Sara , Santos Isabel C. , Pereira Giovannia A. , Geraldes Carlos F. G. C. , Kotek Jan , Hermann Petr , Vaněk Jakub , Lubal Přemysl , Kubíček Vojtěch , Tóth Éva , Santos Isabel 
Published: June 2010

AbstractComplexes of 4,10‐bis(phosphonomethyl)‐1,4,7,10‐tetraazacyclododecane‐1,7‐diacetic acid (trans‐H6do2a2p, H6L) with transition metal and lanthanide(III) ions were investigated. The stability constant values of the divalent and trivalent metal‐ion complexes are between the corresponding values of H4dota and H8dotp complexes, as a consequence of the ligand basicity. The solid‐state structures of the ligand and of nine lanthanide(III) complexes were determined by X‐ray diffraction. All the complexes are present as twisted‐square‐antiprismatic isomers and their structures can be divided into two series. The first one involves nona‐coordinated complexes of the large lanthanide(III) ions (Ce, Nd, Sm) with a coordinated water molecule. In the series of Sm, Eu, Tb, Dy, Er, Yb, the complexes are octa‐coordinated only by the ligand donor atoms and their coordination cages are more irregular. The formation kinetics and the acid‐assisted dissociation of several LnIII–H6L complexes were investigated at different temperatures and compared with analogous data for complexes of other dota‐like ligands. The [Ce(L)(H2O)]3− complex is the most kinetically inert among complexes of the investigated lanthanide(III) ions (Ce, Eu, Gd, Yb). Among mixed phosphonate–acetate dota analogues, kinetic inertness of the cerium(III) complexes is increased with a higher number of phosphonate arms in the ligand, whereas the opposite is true for europium(III) complexes. According to the 1H NMR spectroscopic pseudo‐contact shifts for the Ce–Eu and Tb–Yb series, the solution structures of the complexes reflect the structures of the [Ce(HL)(H2O)]2− and [Yb(HL)]2− anions, respectively, found in the solid state. However, these solution NMR spectroscopic studies showed that there is no unambiguous relation between 31P/1H lanthanide‐induced shift (LIS) values and coordination of water in the complexes; the values rather express a relative position of the central ions between the N4 and O4 planes.
ChemInform Abstract: Fe2P2O7(H2O)2.
Authors: Giesber III Henry G. , Korzenski Michael B. , Pennington William T. , Kolis Joseph W. 
Published: June 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Spin‐Reorientation and Anisotropy of the Magnetization in Single Crystalline Ho2Co15Si2.
Authors: Tegus O. , Brueck E. , Menovsky A. A. , de Boer F. R. , Buschow K. H. J. 
Published: June 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: The Electrochemistry of C60Ph5Cl: A Very Special Fullerene Derivative.
Authors: Birkett Paul R. , Taylor Roger , Wachter Norbert K. , Carano Maurizio , Paolucci Francesco , Roffia Sergio , Zerbetto Francesco 
Published: June 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Palladium‐Catalyzed Allylic Alkylation Using a Novel Chiral Imino‐Phosphine Ligand Derived from 1‐Mesitylethylamine.
Authors: Kohara Takehiro , Hashimoto Yukihiko , Saigo Kazuhiko 
Published: June 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Addition of Cyclic Ethers and Acetals to Ethyl 3,3‐Difluoro‐2‐methylpropenoate.
Authors: Bumgardner Carl L. , Burgess Jason P. 
Published: June 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Radical Addition Reactions of Fluorinated Species. Part 8. Regioselectivity of Radical Additions to Perfluoroalkylethylenes and Quantum Chemical Calculations. Highly Selective Two‐Step Synthesis of 4‐(Perfluoroalkyl)butane‐1,2‐diols.
Authors: Cirkva Vladimir , Boehm Stanislav , Paleta Oldrich 
Published: June 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Chemoselective C—H Oxidation of Alcohols to Carbonyl Compounds with Iodosobenzene Catalyzed by (Salen)chromium Complex.
Authors: Adam Waldemar , Gelalcha Feyissa Gadissa , Saha‐Moeller Chantu R. , Stegmann Veit R. 
Published: June 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Regioselective Synthesis and Acylation of Cyclic Bis‐(trimethylsiloxy)‐1,3‐dienes — New and Versatile 1,3‐Dianion Synthons.
Authors: Langer Peter , Schneider Toni 
Published: June 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Homo‐Coupling Reactions of Alkenyl‐ and Arylfluorosilanes Mediated by a Copper(I) Salt.
Authors: Nishihara Yasushi , Ikegashira Kazutaka , Toriyama Fumihiko , Mori Atsunori , Hiyama Tamejiro 
Published: June 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Efficient and Selective Protection of Aldehydes as Geminal Diacetates Using LiBr.
Authors: Kumar H. M. Sampath , Reddy B. V. Subba , Reddy P. Thirupathi , Yadav J. S. 
Published: June 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Facile Preparation of 1,1‐Diacetates from Aldehydes with Acetic Anhydride Catalyzed by TiO2/SO42‐ Solid Superacid.
Authors: Jin Tong‐Shou , Ma Yan‐Ran , Sun Xu , Liang Dan , Li Tong‐Shuang 
Published: June 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.