bluuebunny/crossref_metadata_2025_split huggingface dataset:
Odontología: una crisis agravada por la pandemia del Covid-19
Authors: Jiménez-Barbosa Wilson Giovanni , Acuña Gómez Johanna Sareth , Montenegro Martínez Gino 
Published: June 2024

Antecedentes: La pandemia por Covid-19 implicó el establecimiento de medidas de emergencia sanitaria, entre otras, la suspensión y la posterior reapertura progresiva de la atención odontológica. Objetivo: Comprender la forma en que las medidas sanitarias por Covid-19 afectaron a propietarios de consultorios y clínicas odontológicas de Bogotá, Colombia, y si estas agravaron la crisis de la profesión. Métodos: se realizó un estudio cualitativo, entrevistando a siete odontólogos propietarios de clínicas o consultorios odontológicos. Se indagó por las condiciones laborales, cambios económicos, condiciones de contratación y la participación de organizaciones profesionales en la pandemia. Resultados: la odontología ya venía en crisis que se exacerbó a partir de las medidas sanitarias ante la pandemia por Covid-19. Los entrevistados no percibieron una rápida voz de liderazgo de las entidades gubernamentales para establecer protocolos de atención. La gestión administrativa es diferente de acuerdo con las capacidades de las clínicas odontológicas en comparación con los consultorios privados. Finalmente, la pandemia y las restricciones en la movilidad permitieron establecer mejoras en el tiempo compartido con la familia, no obstante, esto afectó los ingresos de los propietarios que los llevó a buscar otras formas de ingreso. Conclusiones: La odontología viene desde hace muchos años en crisis que fue más evidente con las medidas de confinamiento implementadas para controlar la pandemia de Covid-19. Se presentan diferencias en la gestión administrativa en favor de las clínicas odontológicas que fueron fundamentales en el marco de la pandemia.
Assessing Physical Therapists’ Outdoor Walking Recommendations and Neighborhood Walkability for Older Adults
Authors: Karczewski Hannah A. , Blackwood Jennifer 
Published: June 2024

Background/Objectives: Neighborhood walkability is the extent to which built and social environments support walking. Walkability influences older adults’ participation in outdoor physical activity. Identifying factors that influence physical therapists’ (PTs) decisions about prescribing outdoor walking is needed, especially for those who are aging in place. The purpose of this study is to describe the neighborhood walkability knowledge, perceptions, and assessment practices of PTs who work with community-dwelling older adults. Methods: A cross-sectional survey was sent via email to 5,000 PTs nationwide. The 40-item survey assessed walking prescriptions, walkability perceptions and assessments, and gathered demographic data. Categorical variables were compared using Chi-square analyses. Results: Using a total of 122 PTs who worked in outpatient geriatric physical therapy settings, a significant difference was found between perceptions of whether PTs should assess walkability and whether they actually assess walkability (χ2 = 78.7, p < .001). Decisions to prescribe outdoor walking were influenced by the availability (n = 79, 64.8%) and maintenance (n = 11, 9.0%) of sidewalks, crime (n = 9, 7.4%), terrain (n = 7, 5.7%), and aesthetics (n = 6, 4.9%). Objective walkability measures were not used by the respondents. Conclusion: When considering the assessment of walkability, PTs prioritize the built environment over the social environment. Although most believe it is the responsibility of the PT to assess walkability, most do not. Significance/Implications: Assessment of walkability may allow PTs to identify barriers and make more informed recommendations concerning outdoor walking for older adults. Objective measures are available for PTs when prescribing outdoor walking.
Feasibility and Preliminary Effectiveness of an Online Meditation Intervention in Young Adults With Concussion History
Authors: Callahan Christine E. , Donnelly Kyla Z. , Gaylord Susan A. , Faurot Keturah R. , DeFreese J.D. , Kiefer Adam W. , Register-Mihalik Johna K. 
Published: June 2024

Context: Mindfulness interventions (yoga, meditation) in traumatic brain injury populations show promising improvements in injury outcomes. However, most studies include all injury severities and use in-person, general programming lacking accessibility and specificity to the nuance of concussion. Therefore, this study investigated the feasibility and preliminary effectiveness of an online, concussion-focused meditation intervention among young adults with a concussion history. Design: Unblinded, single-arm, pilot intervention. Methods: Fifteen young adults aged 18 to 30 with a concussion history within the past 5 years completed 10 to 20 minutes per day of online, guided meditations for 6 weeks. Feasibility was assessed using the Feasibility of Intervention Measure. Concussion symptoms were measured using the Rivermead Post-Concussion Symptom Questionnaire, perceived stress the Perceived Stress Scale-10, and mindfulness the Five Facet Mindfulness Questionnaire. Descriptive statistics described the study sample and determined intervention adherence and feasibility. Paired sample t tests were used to examine preintervention/postintervention changes in concussion symptoms, perceived stress, and mindfulness, with descriptive statistics further detailing significant t tests. Results: Fifteen participants were enrolled, and 12 completed the intervention. The majority completed 5+ days per week of the meditations, and Feasibility of Intervention Measure (17.4 [1.8]) scores indicated high feasibility. Concussion symptom severity significantly decreased after completing the meditation intervention (11.3 [10.3]) compared with before the intervention (24.5 [17.2]; t[11] = 3.0, P = .01). The number of concussion symptoms reported as worse than before their concussion significantly decreased after completing the meditation intervention (2.7 [3.9]) compared with before the intervention (8.0 [5.7]; t[11] = 3.7, P = .004). Postintervention, 83.33% (n = 10) reported lower concussion symptom severity, and 75.00% (n = 9) reported less concussion symptoms as a mild, moderate, or severe problem (ie, worse than before injury). Conclusions: Findings suggest positive adherence and feasibility of the meditation intervention, with the majority reporting concussion symptom improvement postintervention. Future research is necessary to expand these pilot findings into a large trial investigating concussion-specific meditation programming.
Experiments on Molecular Spectroscopy at the Novosibirsk Terahertz Free Electron Laser
Authors: Kubarev V. V. , Chesnokov E. N. 
Published: June 2024

Abstract
The unique parameters of the Novosibirsk free electron laser (NovoFEL) allow unique experiments on the spectroscopy of molecules to be performed at the Shared Resource Center. The radiation parameters of terahertz NovoFEL are article described in detail. The molecular spectroscopy experiments performed on this laser are given with the corresponding references in which they are described. Possible but as yet unperformed experiments on terahertz NovoFEL in the field of ultra-high-resolution molecular spectroscopy are considered.
Novel BRICHOS-related Defensin-like Antimicrobial Peptide from the Marine Polychaeta Arenicola marina
Authors: Safronova V. N. , Panteleev P. V. , Kruglikov R. N. , Bolosov I. A. , Finkina E. I. , Ovchinnikova T. V. 
Published: June 2024

Abstract
Objective: To date, polychaetes remain a poorly studied class of invertebrate animals in terms of the features of functioning of their immune system and, in particular, the biodiversity of antimicrobial peptides (AMPs). AMPs also known as host defense peptides play a key role in host protection from various pathogens and regulation of the species composition of symbiotic microbes. A study of the biosynthesis of AMPs in polychaetes resulted in the discovery of the so-called BRICHOS domain in the structure of the precursor proteins of a number of such peptides. The conserved structure of this domain makes possible the bioinformatic search for AMP precursors in polychaete transcriptomes. In this work, we found and studied a novel BRICHOS-related AMP from the lugworm Arenicola marina, representing a previously undiscovered in polychaetes a structural family of defensin-like peptides stabilized by four disulfide bonds. Methods: The peptide, designated as AmBRI-44a and containing 44 amino acid residues, was obtained by heterologous expression in Escherichia coli. The peptide secondary structure was investigated by CD spectroscopy in water and dodecylphosphocholine (DPC) micelles. The minimum inhibitory concentrations (MICs) against a wide range of bacterial pathogens were assessed using the two-fold serial dilutions method. Cytotoxicity of AmBRI-44a was studied in vitro on human erythrocytes or adherent cell line HEK293T using the hemoglobin release assay or the MTT test, respectively. The AMBRI-44a potential target was discovered by successive daily subculturing of the AmBRI-44a resistant strain followed by whole-genome sequencing. Results and Discussion: According to CD data, AmBRI-44a is a predominantly β-structured peptide. AmBRI-44a was shown to have a specific activity against a narrow spectrum of Gram-positive bacteria and pronounced cytotoxic effects on the eukaryotic cell line HEK293T. The proposed mechanism of the antibacterial action of this peptide is associated with the inhibition of bacterial cell wall biosynthesis, as indicated by the genetic and phenotypic analysis of selected AmBRI-44a-resistant bacteria Bacillus licheniformis B-511. Conclusions: The resulting data allow us to consider the discovered peptide AmBRI-44a as a candidate compound for the development of an antibiotic agent that could potentially be effective in the treatment of infectious diseases mediated by multidrug-resistant Gram-positive bacteria.
Análise da Oferta de Empreendimentos Turísticos Associados ao Veganismo
Authors: Oliveira Romário Loffredo de , Conti Bruna Ranção 
Published: June 2024

Veganism is a social movement that seeks to end animal exploitation and embraces individual and collective practices to achieve this purpose in the social, environmental, economic and political spheres. Such practices mainly affect the food market, but extend to other economic sectors, such as the tourist market. Therefore, the present study aims to evaluate the relevant adaptations to the vegan niche inserted in this market. The methodological course comprised an exploratory study with a qualitative approach using virtual content analysis and semi-structured interview. Regarding the virtual content analysis, reviews mentioning the terms “vegano/a” on TripAdvisor were searched to find travel agencies and accommodation facilities specialized in serving vegans in the states of São Paulo and Rio de Janeiro. Based on the result of this tourist mapping an after the analysis of their social medias, certain enterprises had their representatives invited to participate in interviews about the services provided to the vegan public. The content analysis of the interviews was carried out from the following categories: gastronomy; sustainability; experiences; hospitality. Among the results of the survey, there was an increase in the offer of tourist products suitable for the vegan public, and how enterprises have been seeking practices that are increasingly oriented to socio-environmental issues, to attract not only vegans, but conscious consumers. This research contributed to the understanding of how veganism has been transforming the tourist market and to the consolidation of a synthesis of management indicators for enterprises that wish to participate in the vegan travel niche.
Role of particle material and geometry in the ballistic performance of nanoparticle-impregnated Kevlar fabric
Authors: Bablu Muhammad Ali , Nowak Nicholas E , Manimala James M 
Published: June 2024

The possibility of enhancing the ballistic performance of aramid fabrics such as Kevlar through the impregnation of nanoparticles is well established. In this study, the influence of the nanoparticle’s specifications such as size, shape, and material on the underlying mechanisms is investigated. A colloid-based treatment process is used to impregnate dry nanoparticles into Kevlar fabric. Using a customized gas gun rig, neat and treated samples are tested to determine the kinetic energy absorbed. Silica, alumina, and zinc oxide nanoparticles ranging from 10 to 125 nm, with spherical or cylindrical shape are considered. Silica treated samples perform significantly better (83% increase in energy absorbed vs neat fabric) than alumina or zinc oxide treated samples, likely due to greater agglomeration between yarn interfaces leading to enhanced frictional mechanisms. The exit-face damaged zone area acts as a surrogate for energy absorbed as it correlates well across all samples. Compared to samples with three layers treated individually, samples with three layers treated together display a 21% enhancement in the energy absorbed. Specific energy absorbed for three layers treated together with 80-nm silica is nearly 3 times higher than that for the neat fabric. Samples with three layers treated together with 80-nm silica provide the same performance as the neat fabric for a projectile that is nearly 70 m/s faster. Hybrid structural materials such as nanoparticle-fabric composites offer a promising route to enhance ballistic performance without weight penalty, while being amenable to multifunctional applications.
Manipulation and Financial Market Misconduct in Indonesia
Authors: Sergi Bruno S. , Wongkar Nathan , Suhariono Kenneth L. 
Published: June 2024

In the intricate landscape of Indonesia’s financial sector, the pronounced stock price volatility stands out as a topic of pressing concern. This volatility, often perceived as a hallmark of emerging markets, manifests distinctly in the Indonesian context. This paper uses the UMA (Unusual Market Activity) as a primary reference point to unravel the patterns underlying stock-price manipulations. Benchmarked against the IDX80 and LQ45 indexes, our exploration reveals overarching trends in the behavior of potentially manipulated stocks. To refine our analysis further, we incorporated machine learning tools, including a Support Vector Machine (SVM) and a Random Forest classifier, as supportive instruments. Our study offers a panoramic view of Indonesia’s stock market dynamics, shedding light on areas that warrant regulatory attention and paving the way for informed decision-making for investors and market stakeholders. G1, G4, G12, G14.
A pharmacist-led heart failure stewardship initiative for guideline-directed medical therapy in hospitalized patients with reduced ejection fraction
Authors: MacDonald Gemma-Dawn A. , Johnston Rochelle M. , Flewelling Andrew J. 
Published: June 2024

Background: Heart failure with reduced ejection fraction (HFrEF) is a progressive disease with high rates of hospitalization and mortality. The Canadian Cardiovascular Society recommends treating patients with HFrEF with medications from 4 standard medication classes—this is known as guideline-directed medical therapy (GDMT). However, despite clear evidence and recommendations, GDMT agents are known to be underutilized in the HFrEF population. Objective: To determine if the implementation of a prescriber-alert stewardship tool for hospitalized patients with HFrEF will increase the frequency of GDMT prescribing with all classes during hospitalization. Methods: Utilization of GDMT in patients with HFrEF between admission and discharge pre- and post-implementation of a prescriber alert stewardship tool was compared. Patients admitted to a cardiology stepdown unit between January and April 2022 had a stewardship-alert tool placed on their chart for physician review, while those admitted during the same time frame 1 year prior did not. Results: Following the use of a prescriber alert, there was a statistically significant increase in prescribing for β-blockers (38.1% to 95.2%; p < 0.001), mineralocorticoid receptor antagonists (9.5% to 66.7%; p < 0.001) and combination GDMT (9.5% to 52.4%; p = 0.004) from admission to discharge. A statistically significant increase in the prescribing of β-blockers (47.6% to 76.2%; p = 0.004) and angiotensin-converting enzyme inhibitors (21.4% to 40.5%; p = 0.008) was still observed without the use of the prescriber alert. Conclusion: A pharmacist-led heart failure stewardship tool initiative increased uptake of GDMT in patients with HFrEF.
Assembly and comparative analysis of the complete mitochondrial genome of Brassica rapa var. Purpuraria
Authors: Gong Yihui , Xie Xin , Zhou Guihua , Chen Meiyu , Chen Zhiyin , Li Peng , Huang Hua 
Published: June 2024

Abstract
Background
Purple flowering stalk (Brassica rapa var. purpuraria) is a widely cultivated plant with high nutritional and medicinal value and exhibiting strong adaptability during growing. Mitochondrial (mt) play important role in plant cells for energy production, developing with an independent genetic system. Therefore, it is meaningful to assemble and annotate the functions for the mt genome of plants independently. Though there have been several reports referring the mt genome of in Brassica species, the genome of mt in B. rapa var. purpuraria and its functional gene variations when compared to its closely related species has not yet been addressed.

Results
The mt genome of B. rapa var. purpuraria was assembled through the Illumina and Nanopore sequencing platforms, which revealed a length of 219,775 bp with a typical circular structure. The base composition of the whole B. rapa var. purpuraria mt genome revealed A (27.45%), T (27.31%), C (22.91%), and G (22.32%). 59 functional genes, composing of 33 protein-coding genes (PCGs), 23 tRNA genes, and 3 rRNA genes, were annotated. The sequence repeats, codon usage, RNA editing, nucleotide diversity and gene transfer between the cp genome and mt genome were examined in the B. rapa var. purpuraria mt genome. Phylogenetic analysis show that B. rapa var. Purpuraria was closely related to B. rapa subsp. Oleifera and B. juncea. Ka/Ks analysis reflected that most of the PCGs in the B. rapa var. Purpuraria were negatively selected, illustrating that those mt genes were conserved during evolution.

Conclusions
The results of our findings provide valuable information on the B.rapa var. Purpuraria genome, which might facilitate molecular breeding, genetic variation and evolutionary researches for Brassica species in the future.
Effects of cold acclimation on serum biochemical parameters and metabolite profiles in Schizothorax prenanti
Authors: Wang Aiyu , Zhang Run , Zhang Xianshu , Chen Chunjie , Gong Quan , Wang Linjie , Wang Yan 
Published: June 2024

Abstract
Background
Environmental temperature is critical in regulating biological functions in fish. S. prenanti is a kind of cold-water fish, but of which we have little knowledge about the metabolic adaptation and physiological responses to long-term cold acclimation.

Results
In this study, we determined the physiological responses of S. prenanti serum after 30 days of exposure to 6℃. Compared with the control group, the levels of TC, TG, and LDL-C in the serum were significantly (P < 0.05) increased, and the level of glucose was significantly (P < 0.05) decreased under cold acclimation. Cold acclimation had no effect on the gene expression of pro-inflammatory factors and anti-inflammatory factors of S. prenanti. Metabolomics analysis by LC-MS showed that a total of 60 differential expressed metabolites were identified after cold acclimation, which involved in biosynthesis of amino acids, biosynthesis of unsaturated fatty acids, steroid degradation, purine metabolism, and citrate cycle pathways.

Conclusion
The results indicate that cold acclimation can alter serum metabolites and metabolic pathways to alter energy metabolism and provide insights for the physiological regulation of cold-water fish in response to cold acclimation.
Molecular mechanism of brassinosteroids involved in root gravity response based on transcriptome analysis
Authors: Bai Qunwei , Xuan Shurong , Li Wenjuan , Ali Khawar , Zheng Bowen , Ren Hongyan 
Published: June 2024

Abstract
Background
Brassinosteroids (BRs) are a class of phytohormones that regulate a wide range of developmental processes in plants. BR-associated mutants display impaired growth and response to developmental and environmental stimuli.

Results
Here, we found that a BR-deficient mutant det2-1 displayed abnormal root gravitropic growth in Arabidopsis, which was not present in other BR mutants. To further elucidate the role of DET2 in gravity, we performed transcriptome sequencing and analysis of det2-1 and bri1-116, bri1 null mutant allele. Expression levels of auxin, gibberellin, cytokinin, and other related genes in the two mutants of det2-1 and bri1-116 were basically the same. However, we only found that a large number of JAZ (JASMONATE ZIM-domain) genes and jasmonate synthesis-related genes were upregulated in det2-1 mutant, suggesting increased levels of endogenous JA.

Conclusions
Our results also suggested that DET2 not only plays a role in BR synthesis but may also be involved in JA regulation. Our study provides a new insight into the molecular mechanism of BRs on the root gravitropism.
Effective dosage and mode of exercise for enhancing cognitive function in Alzheimer's disease and dementia: a systematic review and Bayesian Model-Based Network Meta-analysis of RCTs
Authors: Yuan Yuan , Yang Yong , Hu XiaoFei , Zhang Lin , Xiong Zhiyu , Bai Ying , Zeng JiaLe , Xu Feng 
Published: June 2024

Abstract
Objective
Research the dose–response relationship between overall and certain types of exercise and cognitive function in older adults with Alzheimer's disease and dementia.

Design
Systemic and Bayesian Model-Based Network Meta-Analysis.

Methods
In our study, we analyzed data from randomized controlled trials investigating the effects of different exercises on cognitive outcomes in older adults with AD. We searched the Web of Science, PubMed, Cochrane Central Register of Controlled Trials, and Embase up to November 2023. Using the Cochrane Risk of Bias tool (Rob2) for quality assessment and R software with the MBNMA package for data analysis, we determined standard mean differences (SMDs) and 95% confidence intervals (95%CrI) to evaluate exercise's impact on cognitive function in AD.

Results
Twenty-seven studies with 2,242 AD patients revealed a nonlinear relationship between exercise and cognitive improvement in AD patients. We observed significant cognitive enhancements at an effective exercise dose of up to 1000 METs-min/week (SMDs: 0.535, SD: 0.269, 95% CrI: 0.023 to 1.092). The optimal dose was found to be 650 METs-min/week (SMDs: 0.691, SD: 0.169, 95% CrI: 0.373 to 1.039), with AE (Aerobic exercise) being particularly effective. For AE, the optimal cognitive enhancement dose was determined to be 660 METs-min/week (SMDs: 0.909, SD: 0.219, 95% CrI: 0.495 to 1.362).

Conclusion
Nonlinear dose–response relationship between exercise and cognitive improvement in Alzheimer’s disease, with the optimal AE dose identified at 660 METs-min/week for enhancing cognitive function in AD.