bluuebunny/crossref_metadata_2025_split huggingface dataset:
Phosphorylation of ERK in the spinal dorsal horn following pancreatic pronociceptive stimuli with proteinase‐activated receptor‐2 agonists and hydrogen sulfide in rats: Evidence for involvement of distinct mechanisms
Authors: Fukushima Osamu , Nishimura Sachiyo , Matsunami Maho , Aoki Yuka , Nishikawa Hiroyuki , Ishikura Hiroyasu , Kawabata Atsufumi 
Published: August 2010

AbstractNoxious stimuli cause prompt phosphorylation of extracellular signal‐regulated kinase (ERK) in the spinal dorsal horn that contributes to facilitation of pain sensation and is often used as an immediate marker for excitation of spinal neurons following somatic and colonic nociception. Here we asked whether two distinct pronociceptive stimuli with proteinase‐activated receptor‐2 (PAR2) agonists and hydrogen sulfide (H2S) in the pancreas cause phosphorylation of ERK in the spinal dorsal horn and also examined involvement of their possible downstream signaling molecules, transient receptor potential vanilloid‐1 (TRPV1) and T‐type Ca2+ channels, respectively. Capsaicin (a TRPV1 agonist), trypsin (an endogenous PAR2 agonist), SLIGRL‐NH2 (a PAR2‐activating peptide), and NaHS (an H2S donor) were infused into the pancreatic duct in anesthetized rats, and phosphorylated ERK in the spinal cord was detected by immunohistochemistry. Intraductal administration of capsaicin and trypsin caused prompt phosphorylation of ERK in the superficial layers of T9, but not T5 or T12, spinal dorsal horn. SLIGRL‐NH2 and NaHS, administered in the same manner, also produced ERK phosphorylation in the corresponding spinal regions. Mibefradil, a T‐type Ca2+ channel blocker, abolished the phosphorylation of ERK caused by intraductal NaHS but not SLIGRL‐NH2. In contrast, capsazepine, an inhibitor of TRPV1, suppressed the phosphorylation of ERK caused by intraductal SLIGRL‐NH2 but not NaHS. Our data thus demonstrate that pancreatic pronociceptive stimuli with PAR2 agonists and H2S cause ERK phosphorylation in the spinal dorsal horn, through activation of TRPV1 and T‐type Ca2+ channels, respectively, and that those two pronociceptive pathways are independent of each other. © 2010 Wiley‐Liss, Inc.
Role of transglutaminase 2 in apoptosis induced by hydrogen peroxide in human chondrocytes
Authors: Han Ilkyu , Park Hee Jung , Seong Sang Cheol , Lee Sahnghoon , Kim In‐Gyu , Lee Myung Chul 
Published: August 2010

AbstractChondrocyte apoptosis has been implicated in the pathogenesis of osteoarthritis. Transglutaminase 2 (TG2), the expression of which is higher in osteoarthritis patients, has been shown to be up‐regulated during apoptosis in many experimental models. This study investigated the expression and role of TG2 in human chondrocytes undergoing apoptosis induced by hydrogen peroxide (H2O2). Human chondrocytes were obtained from the knee articular cartilage of patients undergoing total joint arthroplasty. Apoptosis was induced by H2O2 and was measured with Annexin‐V flow cytometry, DNA Fragmentation ELISA and DAPI staining. Western Blot, an in situ activity assay and immunocytochemistry were used to examine TG2 expression. The role of TG2 was evaluated by TG‐specific siRNA transfection and monodansylcadaverine (MDC), a competitive substrate for TG2. H2O2 induced apoptosis of human chondrocytes in a dose‐ and time‐dependent manner. The level of TG2 expression was higher in the chondrocytes undergoing H2O2‐induced apoptosis. Inhibition of TG2 by siRNA or MDC increased the level of apoptosis in the H2O2‐treated chondrocytes. TG2 expression is higher in human chondrocytes undergoing apoptosis, and inhibition of TG2 leads to increased apoptosis. These results may raise the possibility of TG2 as a modulator of cartilage damage in osteoarthritis by offering protection against chondrocyte apoptosis. © 2010 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 29:252–257, 2011
Micro‐conformational transitions in L‐alanine single crystals revisited by low wavenumber Raman spectroscopy
Authors: Kolesov Boris A. , Boldyreva Elena V. 
Published: August 2010

AbstractThe properties of the crystalline L‐alanine have been attracting attention for a very long time, and there is much controversy in the results already reported. One of the most interesting problems is that of the localization of vibrational energy and the micro‐transitions (named ‘breathers’ by Barthes et al. [M. Barthes, H. N. Bordallo, F. Dénoyer, J.‐E. Lorenzo, J. Zaccaro, A. Robert, F. Zontone, Eur. Phys. J. 2004, B37, 375]. In the present study, we have addressed this problem once again, having measured the high‐resolution polarized Raman spectra in the temperature range from 4 to 300 K. The wavenumber, bandwidth and intensity of all the modes polarized along the c‐axis (the axis of the head‐to‐tail chains of zwitterion in the structure) show discontinuities at 30–50, 100–120 and 180–220 K. We interpret the observed anomalies of spectral characteristics in terms of micro‐conformational transitions accompanied by the rearrangement of the hydrogen‐bond network and relate them to previously published work. Copyright © 2010 John Wiley & Sons, Ltd.
Raman and SERS study on cimetidine–metal complexes with biomedical interest
Authors: Bonora Sergio , Foggia Michele Di , Tugnoli Vitaliano , Righi Valeria , Benassi Enrico , Maris Assimo 
Published: August 2010

AbstractCimetidine (cim) is one of the most potent histamine H2‐receptor antagonists for inhibiting excessive acid secretion caused by histamine; it has been hypothesized that the therapeutic effects can be related to its interactions with metal ions. Raman spectra of the solid cim with Co(II), Cu(II), Ni(II) and Zn(II) metal complexes show that they can adopt two different structures: one is octahedral and the other, with Zn(II), is probably tetrahedral. The octahedral structure appears to be distorted both by the different metal ions as well as by the different anion present. The study was extended to very dilute solutions (ppm range) by using the surface‐enhanced Raman scattering (SERS) technique, mimicking the physiological concentrations of cim and its metal complexes. SERS spectra suggest that, upon the binding of cim to silver colloids, the formation of stable 1:2 cim–metal complexes is excluded, the formation of 1:1 adduct appearing more probable; in this product the metal reaches its total coordination shell by complexion with water molecules. To better explain the binding mechanism of cim to a metal (Ag) surface, we performed theoretical B3LYP calculations on cim alone as well as on cim bonded to an Ag2 metal cluster in presence of water, observing a sufficiently good agreement between experimental and theoretical wavenumbers. Copyright © 2010 John Wiley & Sons, Ltd.
Raman identification of strongly absorbing phases: the ceramic black pigments
Authors: Caggiani Maria Cristina , Colomban Philippe 
Published: August 2010

AbstractTo get black decorations requires high ceramic technology and there are different ways of achieving this. Their identification can be very useful to discriminate between different manufactures or periods of production but this information is often very hard to achieve because of their strong absorption of the illuminating laser beam, whatever the wavelength used, causing a very low scattering intensity and, in case of power increase, a transformation of phase which may lead to the misinterpretation of the spectra obtained. We test the use of five instruments with different characteristics (wavelength and power of excitation, spectral resolution, filters and microscope) applied to a group of heterogeneous samples which have in common the presence of a black glaze. The results obtained (manganese oxides, cobalt oxides or a mixture of the two even with the addition of haematite) are compared considering the different methodologies used and leading to a preference towards high‐sensitivity rather than high‐resolution spectrometers, notch‐filtered rather than edge‐filtered instruments and microscopic configuration used on freshly created cross‐sections. The importance of the objective choice is demonstrated. Small grains may be preferred. Copyright © 2010 John Wiley & Sons, Ltd.
Chromatographic behavior of a new hybrid type RP material containing silica bonded 1,3‐alternate 25,27‐bis‐[cyanopropyloxy]‐26,28‐bis‐[3‐propyloxy]‐calix[4]arene
Authors: Śliwka‐Kaszyńska Magdalena , Łępicka Kamila , Ślebioda Marek 
Published: August 2010

AbstractA novel 1,3‐alternate 25,27‐bis‐[cyanopropyloxy]‐26,28‐bis‐[3‐propyloxy]‐calix[4]arene‐bonded silica gel stationary phase (CalixPrCN) was prepared and its structure was confirmed by ATR‐FTIR spectroscopy and elemental analysis. The CalixPrCN phase was characterized in terms of its surface coverage, hydrophobic selectivity, aromatic selectivity, shape selectivity, hydrogen bonding capacity, residue metal content, and silanol activity based on Tanaka, Lindner, and SMR 870 test protocols. The effect of the acetonitrile content on the retention and selectivity of the selected neutral, basic, and acidic solutes was studied. The neutral and acidic analytes exhibited classical RP behavior, in which retention time decreases with increasing acetonitrile content. In contrast, basic analytes showed an increase in retention at low and high percentages of acetonitrile, forming “U‐shaped” retention profiles. The new calixarene phase was compared with previously reported 1,3‐alternate 25,27‐bis‐[propyloxy]‐26,28‐bis‐[3‐propyloxy]‐calix[4]arene stationary phase and commercial cyanopropyl column. The results indicate that the CalixPrCN stationary phase behaves like RP packing; however, inclusion complex formation, dipole–dipole, and π–π interactions seem to be involved in the separation process. The selectivity of this phase was demonstrated in separation of polynuclear aromatic hydrocarbons, non‐steroidal anti‐inflammatory drugs, and sulfonamides as analytes.
On comparing competing models of PTSD: Response to Simms
Authors: Miller Mark W. 
Published: August 2010

AbstractThis is a response to Simms' commentary on Miller, Wolf, Harrington, Brown, Kaloupek, and Keane (2010) comparing the convergent and discriminant validity of two 4‐factor models of posttraumatic stress disorder (PTSD) using external measures of comorbidity. The author reviews the importance of the distinction between numbing and hyperarousal, clarifies the logic and rationale for the study's aims and hypotheses, and responds to specific concerns about the conclusions. He addresses the relationship between hyperarousal symptoms and internalizing comorbidity and notes the limitations of representing the latter construct using only two symptoms. The author concludes by underscoring the need for future research to place greater emphasis on examining the external correlates of alternative models of the factor structure of PTSD.
Melanocytic nevi with spitz differentiation: Diagnosis and management
Authors: Ahmadi Neda , Davison Steven P. , Kauffman Catharine L. 
Published: August 2010

AbstractObjectives:Melanocytic proliferations with Spitz differentiation present a difficult clinicopathologic dilemma, as their spectrum ranges from benign to malignant. Distinct entities include Spitz nevus, atypical Spitz nevus, and Spitzoid melanoma. Their histopathologic differentiation can be challenging, and cases of Spitzoid melanoma initially diagnosed as benign Spitz nevi are reported in the literature. The goal of this article is to discuss the diagnostic tools (including comparative genomic hybridization), which may be helpful in differentiating benign Spitz nevi from malignant melanoma with Spitzoid features, and to propose an appropriate management strategy for each entity.Study Design:Retrospective case reports.Methods:Medical records of patients referred for suspicious nevi were reviewed. Data regarding demographics, site, pathology reports, and treatment were reviewed.Results:Four patients with three distinct diagnoses involving Spitz differentiation were identified. The pathologic interpretation of these biopsies was difficult and multiple dermatopathologists were involved. All four patients underwent excision with or without sentinel node biopsy.Conclusions:Otolaryngologists, plastic surgeons and dermatopathologists will encounter patients who have melanocytic lesions with Spitz differentiation at some point in their career. The management of these patients is significantly impacted by the histopathologic diagnosis, and should not be undertaken until it is confirmed, possibly with comparative genomic hybridization. In our experience, it is not unusual to have multiple independent pathologic examinations. We believe that a team approach between the surgeon and the dermatopathologist is crucial when diagnosing and managing patients with Spitz lesions. Laryngoscope, 2010
A rare case of laryngeal dystonia associated with neurosyphilis: Response to botulinum toxin injection1
Authors: Ho Ki‐Hong Kevin , Wright Christopher C. , Underbrink Michael P. 
Published: August 2010

AbstractWe report a unique case of laryngeal dystonia in a 43‐year‐old male with neurosyphilis who underwent successful treatment with botulinum toxin injection. To date there have been no reports of laryngeal dystonia associated with neurosyphilis. The patient initially presented with strained and stuttering voice despite systemic penicillin therapy. After 2 months of speech therapy with limited relief, the patient received botulinum toxin injection to each thyroarytenoid muscle. Postinjection videostroboscopy showed marked improvement of voice quality. Laryngoscope, 2011
Posttransplant bacteremia in adult living donor liver transplant recipients
Authors: Iida Taku , Kaido Toshimi , Yagi Shintaro , Yoshizawa Atsushi , Hata Koichiro , Mizumoto Masaki , Mori Akira , Ogura Yasuhiro , Oike Fumitaka , Uemoto Shinji 
Published: August 2010

Abstract
Infectious complications such as bacteremia after living donor liver transplantation (LDLT) are associated with significant morbidity and mortality. We retrospectively analyzed the frequency and characteristics of posttransplant bacteremia in 181 adult LDLT recipients between April 2006 and November 2009, and we evaluated the risk factors for posttransplant bacteremia. One hundred seventeen episodes of bacteremia occurred in 62 of 181 recipients (34.3%) within 12 days (median) after transplantation (range = 1-71 days). The most frequently isolated pathogens were Pseudomonas aeruginosa (26 episodes), methicillin-resistant coagulase-negative staphylococci (22 episodes), and Enterococcus sp. (11 episodes). The overall survival rate at 1 year for patients with bacteremia (n = 62) was significantly lower than the rate for patients without bacteremia (n = 119; 69.6% versus 92.3%, respectively, P < 0.0001). Multivariate analysis showed that Child-Pugh class C (P = 0.0002), preoperative massive pleural effusion or ascites requiring drainage (P = 0.0384), postoperative cytomegalovirus infection (P = 0.0014), ABO incompatibility (P = 0.0188), and older donor age (P = 0.015) were independent risk factors for postoperative bacteremia. In conclusion, bacteremia occurred at a high rate after adult LDLT and induced a higher mortality rate in those who developed it. Infection control may play a pivotal role in improving early outcomes after LDLT. Liver Transpl 16:1379–1385, 2010. © 2010 AASLD.
Long-term survival after 67 hours of anhepatic state due to primary liver allograft nonfunction
Authors: Arora Harendra , Thekkekandam Janine , Tesche Leora , Sweeting Raeshell , Gerber David A. , Hayashi Paul H. , Andreoni Kenneth , Kozlowski Tomasz 
Published: August 2010

Abstract
Primary liver allograft nonfunction immediately after transplantation poses a life-threatening situation for the recipient. Emergency retransplantation may not be immediately possible due to organ unavailability. Total hepatectomy with temporary portacaval shunt has been described as a bridge to retransplantation when the presence of the graft appears to be harming the recipient. Case reports of retransplantation after total hepatectomy with anhepatic times greater than 48 hours routinely describe poor outcomes. We present a case with excellent patient outcome after 95 hours of clinical anhepatic state, including 67 hours of anatomical anhepatic time, because of primary liver allograft nonfunction. This case report documents the longest anhepatic time with subsequent successful transplant to date. Liver Transpl 16:1428–1433, 2010. © 2010 AASLD.
Quality of life for donors after living donor liver transplantation: A review of the literature
Authors: Parikh Neehar D. , Ladner Daniela , Abecassis Michael , Butt Zeeshan 
Published: August 2010

Abstract
Living donor liver transplantation (LDLT) decreases the shortage of liver grafts for patients in need of a liver transplant, but it involves 2 patients: a recipient and a living donor. Despite the magnitude of the procedure for LDLT donors, only a few studies have investigated the effect of LDLT on the quality of life (QOL) of donors. We performed a systematic search of the MEDLINE database to identify peer-reviewed articles assessing QOL in adults after LDLT donation. Nineteen studies describing 768 unique donors met our inclusion criteria for this review. The median number of donors enrolled in each study was 30 (range = 10-143), and the median follow-up period was 10.4 months (range = 3-51.3 months). Before donation, donor QOL was significantly better than that in control adult populations across all measured QOL domains. Within the first 3 months after donation, the physical domains of QOL were significantly worse than the predonation levels, but they returned to baseline levels within 6 months for the majority of patients (80%-93%). Mental domains of QOL remained unchanged throughout the donation process. Common donor concerns after LDLT included bloating, loss of muscle tone, poor body image, and fatigue. In conclusion, according to our review of the existing literature, most LDLT donors return to their baseline QOL within 6 months. However, there is a lack of long-term data on donor QOL after LDLT, and few standardized assessments include measures of common patient concerns. Additional studies are necessary to develop a comprehensive risk profile for LDLT that includes a rigorous assessment of donor QOL. Liver Transpl 16:1352–1358, 2010. © 2010 AASLD.
Extrusion Foaming of Poly(styrene‐co‐acrylonitrile)/Clay Nanocomposites Using Supercritical CO2
Authors: Urbanczyk Laetitia , Alexandre Michaël , Detrembleur Christophe , Jérôme Christine , Calberg Cédric 
Published: August 2010

AbstractSupercritical CO2 has been used as a blowing agent to foam poly(styrene‐co‐acrylonitrile)‐based materials in a single screw extruder specially adapted to allow fluid injection. The cellular morphology depends on foaming temperature, more regular cells being obtained with decreasing extrusion temperature. In a second step, a natural and an organomodified nanoclay have been added for the purpose of imparting some flame resistance to the foamed material. The filler efficiency in reducing sample combustion rate appeared to be dependent on its delamination level inside the matrix and better results were obtained when the organomodified clay was first delaminated in the polymer in an efficient twin screw extruder using water assistance, prior to foaming in the single screw extruder.magnified image
Applications of Oligomers for Nanostructured Conducting Polymers
Authors: Wang Yue , Tran Henry D. , Kaner Richard B. 
Published: August 2010

AbstractThis Feature Article provides an overview of the distinctive nanostructures that aniline oligomers form and the applications of these oligomers for shaping the nanoscale morphologies and chirality of conducting polymers. We focus on the synthetic methods for achieving such goals and highlight the underlying mechanisms. The clear advantages of each method and their possible drawbacks are discussed. Assembly and applications of these novel organic (semi)conducting nanomaterials are also outlined. We conclude this article with our perspective on the main challenges, new opportunities, and future directions for this nascent yet vibrant field of research.magnified image
Importance of the Position of the Chromophore Group on the Dissociation Process of Light Sensitive Alkoxyamines
Authors: Guillaneuf Yohann , Versace Davy‐Louis , Bertin Denis , Lalevée Jacques , Gigmes Didier , Fouassier Jean‐Pierre 
Published: August 2010

AbstractNew photosensitive alkoxyamines have been designed using molecular orbital calculations to improve the selective CO versus NO cleavage. The targeted light‐sensitive alkoxyamine is synthesized in one step and its reactivity under UV has been investigated using both ESR and LFP. The ability of this alkoxyamine to control the photopolymerization of n‐butyl acrylate is evidenced through a process called nitroxide‐mediated photopolymerization NMP2. The selected alkoxyamine is finally used to prepare covalently bonded multilayered micropatterns. This original application highlights the high potential of this technique for some specific applications that require spatial control.magnified image
Impact of imaging landmark on the risk of MRI‐related heating near implanted medical devices like cardiac pacemaker leads
Authors: Nordbeck Peter , Ritter Oliver , Weiss Ingo , Warmuth Marcus , Gensler Daniel , Burkard Natalie , Herold Volker , Jakob Peter M. , Ertl Georg , Ladd Mark E. , Quick Harald H. , Bauer Wolfgang R. 
Published: August 2010

AbstractImplanted medical devices such as cardiac pacemakers pose a potential hazard in magnetic resonance imaging. Electromagnetic fields have been shown to cause severe radio frequency‐induced tissue heating in some cases. Imaging exclusion zones have been proposed as an instrument to reduce patient risk. The purpose of this study was to further assess the impact of the imaging landmark on the risk for unintended implant heating by measuring the radio frequency‐induced electric fields in a body phantom under several imaging conditions at 1.5T. The results show that global radio frequency‐induced coupling is highest with the torso centered along the superior–inferior direction of the transmit coil. The induced E‐fields inside the body shift when changing body positioning, reducing both global and local radio frequency coupling if body and/or conductive implant are moved out from the transmit coil center along the z‐direction. Adequate selection of magnetic resonance imaging landmark can significantly reduce potential hazards in patients with implanted medical devices. Magn Reson Med, 2010. © 2010 Wiley‐Liss, Inc.
Analytic solution for the nucleolus of a three‐player cooperative game
Authors: Leng Mingming , Parlar Mahmut 
Published: August 2010

AbstractThe nucleolus solution for cooperative games in characteristic function form is usually computed numerically by solving a sequence of linear programing (LP) problems, or by solving a single, but very large‐scale, LP problem. This article proposes an algebraic method to compute the nucleolus solution analytically (i.e., in closed‐form) for a three‐player cooperative game in characteristic function form. We first consider cooperative games with empty core and derive a formula to compute the nucleolus solution. Next, we examine cooperative games with nonempty core and calculate the nucleolus solution analytically for five possible cases arising from the relationship among the value functions of different coalitions. © 2010 Wiley Periodicals, Inc. Naval Research Logistics, 2010