bluuebunny/crossref_metadata_2025_split huggingface dataset:
pH‐Controllable Redox Responsive Amphiphilic Viologens for Switchable Emulsions
Authors: Zhang Xinyue , Peng Chifang , Jiang Jianzhong 
Published: April 2024

AbstractA pH and redox dual responsive amphiphilic viologen is synthesized, which can be reversibly transformed among the zwitterionic (SVa), monovalent anionic (SV+), and divalent anionic (SVH2+) forms upon pH variation, exhibiting pH‐controllable redox responsive properties. Switchable Pickering emulsions with different droplet size and viscosity are prepared by the mixture of hydrophilic silica nanoparticles and the viologens (SV+ or SVH2+) at acidic conditions, while such combination yielded an oil‐in‐dispersion emulsion at neutral pH value. Not only can rapid reversible demulsification/stabilization of the Pickering emulsions be achieved by redox reactions, but the rate of redox‐demulsification can also be controlled by pH trigger. The dual‐responsive amphiphilic viologens have potential applications in developing intelligent colloid materials and molecular logic systems.
A Universal Biomacromolecule‐Enabled Assembly Strategy for Constructing Multifunctional Aerogels with 90% Inorganic Mass Loading from Inert Nano‐Building Blocks
Authors: Yang Di , Dong Xiangyang , Jiang Linbin , Liu Fangtian , Ma Shuai , Shi Xiaowen , Du Yumin , Chen Chaoji , Deng Hongbing 
Published: April 2024

AbstractInert inorganic nano‐building blocks, such as carbon nanotubes (CNTs) and boron nitride (BN) nanosheets, possess excellent physicochemical properties. However, it remains challenging to build aerogels with these inert nanomaterials unless they are chemically modified or compounded with petrochemical polymers, which affects their intrinsic properties and is usually not environmentally friendly. Here, a universal biomacromolecule‐enabled assembly strategy is proposed to construct aerogels with 90 wt% ultrahigh inorganic loading. The super‐high inorganic content is beneficial for exploiting the inherent properties of inert nanomaterials in multifunctional applications. Taking chitosan‐CNTs aerogel as a proof‐of‐concept demonstration, it delivers sensitive pressure response as a pressure sensor, an ultrahigh sunlight absorption (94.5%) raising temperature under light (from 25 to 71 °C within 1 min) for clean‐up of crude oil spills, and superior electromagnetic interference shielding performance of up to 68.9 dB. This strategy paves the way for the multifunctional application of inert nanomaterials by constructing aerogels with ultrahigh inorganic loading.
Optimizing heat transfer rate with sensitivity analysis on nonlinear radiative hydromagnetic hybrid nanofluid flow considering catalytic effects and slip condition: Hamilton–Crosser and Yamada–Ota modelling
Authors: Panda Subhajit , Ontela Surender , Pattnaik P. K. , Mishra S. R. 
Published: April 2024

AbstractIn current investigation the optimization of heat transportation rate in a nonlinear radiative buoyancy‐driven hydromagnetic carbon nanotube (CNT) hybrid nanofluid flow is analysed. The proposed catalytic effects and slip condition is accounted for the real‐world complexities of the system. The Hamilton–Crosser (HC) and Yamada–Ota (YO) models are employed to characterize the behaviour of the nanofluid. The primary objective is to enhance the heat transmission rate, which is crucial for various engineering applications such as thermal management, energy systems and so forth. To achieve this, sensitivity analysis is performed to identify the most influential parameters affecting heat transfer in the system. By understanding the sensitivity of these parameters, the performance of the system can be improvised. The study focuses on the interplay between key factors including radiative heat transfer, buoyancy‐driven flow, magnetic field influence, catalytic effects, and slip condition. The presence of CNTs in the nanofluid adds another dimension to the complexity of the system that explores the effects of varying the concentration and size of CNTs on the heat transfer rate. By utilizing advanced mathematical modelling and numerical simulations, the performance of the system under different scenarios and identify the optimal conditions for maximizing heat transfer rate is evaluated. The findings of this research provide valuable insights into the design and optimization of heat transfer systems involving nanofluids with nonlinear radiative and hydromagnetic effects. The observation shows that, irrespective to single wall and multi wall CNT nanoparticles the fluid velocity attenuates significantly whereas it favours in enhancing the fluid temperature. Further, the comparative analysis reveals that the heat transfer augments in the case of HC model than that of YO model.
Deformation and Frictional Failure of Granular Media in 3D Analog and Numerical Experiments
Authors: Ioannidi P. I. , McLafferty S. , Reber J. E. , Morra G. , Weatherley D. 
Published: April 2024

AbstractFrictional sliding along grain boundaries in brittle shear zones can result in the fragmentation of individual grains, which ultimately can impact slip dynamics. During deformation at small scales, stick–slip motion can occur between grains when existing force chains break due to grain rearrangement or failure, resulting in frictional sliding of granular material. The rearrangement of the grains leads to dilation of the granular package, reducing the shear stress and subsequently leading to slip. Here, we conduct physical experiments employing HydroOrbs, an elasto-plastic material, to investigate grain comminution in granular media under simple shear conditions. Our findings demonstrate that the degree of grain comminution is dependent on both the normal force and the size of the grains. Using the experimental setup, we benchmark Discrete Element Method (DEM) numerical models, which are capable of simulating the movement, rotation, and fracturing of elasto-plastic grains subjected to simple shear. The DEM models successfully replicate both grain comminution patterns and horizontal force fluctuations observed in our physical experiments. They show that increasing normal forces correlate with higher horizontal forces and more fractured grains. The ability of our DEM models to accurately reproduce experimental results opens up new avenues for investigating various parameter spaces that may not be accessible through traditional laboratory experiments, for example, in assessing how internal friction or cohesion affect deformation in granular systems.
Variability in the summer movements, habitat use and thermal biology of two fish species in a temperate river
Authors: Amat-Trigo Fatima , Tarkan Ali Serhan , Andreou Demetra , Aksu Sadi , Bolland Jonathan D. , Gillingham Phillipa K. , Roberts Catherine Gutmann , Yeldham Mark I. A. , Britton J. Robert 
Published: April 2024

AbstractThe ability of fish to cope with warm water temperatures in summer depends on factors including their thermal traits and the ability of individuals to access cool-water refugia. Knowledge is highly limited on the in situ responses of many fishes to elevated summer temperatures, including whether they express behavioural thermoregulation. The responses of two riverine species to summer water temperatures were tested here using the movement metrics, spatial habitat use and body temperatures of individual European barbel Barbus barbus (‘barbel’) and common bream Abramis brama (‘bream’) versus river temperatures. Acoustic biotelemetry was applied in the lower River Severn basin, western Britain, in summer 2021 (barbel) and 2022 (bream), where individuals could move across > 150 km of river, including a tributary of cooler water. Across all individuals, bream occupied 37 km of river length (mainstem only), with low inter-individual variability in their spatial habitat use, movements and body temperatures. In contrast, barbel occupied 62 km of river (main river/tributary), with relatively high inter-individual variability in spatial habitat use, movements and body temperatures, with higher variation in body temperatures as river temperatures increased (maximum mean daily temperature difference between individuals on the same day: 4.2 °C). Although warmer individuals generally moved more, their activity was greatest at relatively low temperatures and higher flows, and neither species revealed any evidence of behavioural thermoregulation during elevated temperatures. Enabling phenotypically diverse fish populations to express their natural behaviours and thermal preferences in summer water temperatures thus requires maintaining their free-ranging in thermally heterogenous habitats.
Novel dummy molecularly imprinted polymer for simultaneous solid-phase extraction of stanozolol metabolites from urine
Authors: Farag Yomna G. , Hanafi Rasha S. , Hammam Mennatallah A. 
Published: April 2024

AbstractStanozolol, a synthetic derivative of testosterone, is one of the common doping drugs among athletes and bodybuilders. It is metabolized to a large extent and metabolites are detected in urine for a longer duration than the parent compound. In this study, a novel dummy molecularly imprinted polymer (DMIP) is developed as a sorbent for solid-phase extraction of stanozolol metabolites from spiked human urine samples. The optimized DMIP is composed of stanozolol as the dummy template, methacrylic acid as the functional monomer, and ethylene glycol dimethacrylate as the cross-linker in a ratio of 1:10:80. The extracted analytes were quantitively determined using a newly developed and validated ultrahigh-performance liquid chromatography tandem mass spectrometry method, where the limits of detection and quantitation were 0.91 and 1.81 ng mL−1, respectively, fulfilling the minimum required performance limit decided on by the World Anti-Doping Agency. The mean percentage extraction recoveries for 3’-hydroxystanozolol, 4β-hydroxystanozolol, and 16β-hydroxystanozolol are 97.80% ± 13.80, 83.16% ± 7.50, and 69.98% ± 2.02, respectively. As such, the developed DMISPE can serve as an efficient cost-effective tool for doping and regulatory agencies for simultaneous clean-up of the stanozolol metabolites prior to their quantification.
Graphical abstract
Investigating the complete replacement of conventional fat with oleogel on the structural behavior of five different pastry products
Authors: Tanislav Anda E. , Șandru Bianca , Man Simona M. , Pușcaș Andreea , Mureșan Andruța E. , Păucean Adriana , Mureșan Vlad , Mudura Elena 
Published: April 2024

AbstractSaturated and trans fat intake have been linked to an increased risk of developing diseases such as cardiovascular and coronary heart disease, obesity, and myocardial infarction. As a result of the actions and regulations proposed to reduce and eliminate the content of saturated and trans fats, it is necessary to develop and implement new structuring technologies, such as oleogelation. Oleogelation is a promising strategy for structuring liquid oil, that allows the incorporation of vegetable oils rich in unsaturated fatty acids into food matrix and which can provide the functionality of solid fats and improved nutritional characteristics. The partial or total replacement of conventional fats with oleogels in pastry products is of great interest due to their larger consumption. In this research paper, the puff (jam-filled puff pastry) and tender pastries (bow tie cookies, cheese crackers, apple pie, and cookies) have been reformulated by totally replacing of conventional fats with oleogel and the structural behavior in the dynamics of the technological process was evaluated. The textural properties of oleogel were comparable to those of some conventional fats, but frequency sweep measurements showed that the oleogel formulated with refined sunflower oil and carnauba wax (10% w/w) had the highest storage modulus G’ and loss modulus G’’ values when compared to conventional fats (commercial margarine, butter, a mixture of 73% margarine and 27% lard, and puff pastry margarine). The textural properties of oleogel (2.34 N and 2.30 mJ) were significantly different from those of puff pastry margarine (9.78 N and 21.73 mJ), but compared to other conventional fats, the values of hardness (1.42–2.70 N) and adhesiveness (4.40–5.17 mJ) were similar. For conventional and oleogel doughs the storage modulus (Gʹ) were higher than loss modulus (G″) and both increased with the applied frequency (Hz). In terms of the products textural profile, the prototypes formed with oleogel exhibited lower hardness values (2.37–15.64 N) than the conventional products (8.83–19.89 N), indicating the tenderizing effect produced by the oleogel. The fat losses determined during 14 days of storage showed a lower physical stability of the doughs and products formulated with oleogel, most probably due to the destabilization kinetics of the lipid system during the operations of the technological process.
Metabolic modeling of Halomonas campaniensis improves polyhydroxybutyrate production under nitrogen limitation
Authors: Deantas-Jahn Carolina , Mendoza Sebastián N. , Licona-Cassani Cuauhtemoc , Orellana Camila , Saa Pedro A. 
Published: April 2024

Abstract
Poly-hydroxybutyrate (PHB) is an environmentally friendly alternative for conventional fossil fuel-based plastics that is produced by various microorganisms. Large-scale PHB production is challenging due to the comparatively higher biomanufacturing costs. A PHB overproducer is the haloalkaliphilic bacterium Halomonas campaniensis, which has low nutritional requirements and can grow in cultures with high salt concentrations, rendering it resistant to contamination. Despite its virtues, the metabolic capabilities of H. campaniensis as well as the limitations hindering higher PHB production remain poorly studied. To address this limitation, we present HaloGEM, the first high-quality genome-scale metabolic network reconstruction, which encompasses 888 genes, 1528 reactions (1257 gene-associated), and 1274 metabolites. HaloGEM not only displays excellent agreement with previous growth data and experiments from this study, but it also revealed nitrogen as a limiting nutrient when growing aerobically under high salt concentrations using glucose as carbon source. Among different nitrogen source mixtures for optimal growth, HaloGEM predicted glutamate and arginine as a promising mixture producing increases of 54.2% and 153.4% in the biomass yield and PHB titer, respectively. Furthermore, the model was used to predict genetic interventions for increasing PHB yield, which were consistent with the rationale of previously reported strategies. Overall, the presented reconstruction advances our understanding of the metabolic capabilities of H. campaniensis for rationally engineering this next-generation industrial biotechnology platform.

Key points

A comprehensive genome-scale metabolic reconstruction of H. campaniensis was developed.

Experiments and simulations predict N limitation in minimal media under aerobiosis.

In silico media design increased experimental biomass yield and PHB titer.
Radiological diagnosis of prevalent osteoporotic vertebral fracture on radiographs: an interim consensus from a group of experts of the ESSR osteoporosis and metabolism subcommittee
Authors: Wáng Yì Xiáng J. , Diacinti Daniele , Aparisi Gómez Maria Pilar , Santiago Fernando Ruiz , Becce Fabio , Tagliafico Alberto Stefano , Prakash Mahesh , Isaac Amanda , Dalili Danoob , Griffith James F. , Guglielmi Giuseppe , Bazzocchi Alberto 
Published: April 2024

AbstractWhen a low-energy trauma induces an acute vertebral fracture (VF) with clinical symptoms, a definitive diagnosis of osteoporotic vertebral fracture (OVF) can be made. Beyond that, a “gold” radiographic standard to distinguish osteoporotic from non-osteoporotic VFs does not exist. Fracture-shaped vertebral deformity (FSVD) is defined as a deformity radiographically indistinguishable from vertebral fracture according to the best of the reading radiologist’s knowledge. FSVD is not uncommon among young populations with normal bone strength. FSVD among an older population is called osteoporotic-like vertebral fracture (OLVF) when the FSVD is likely to be associated with compromised bone strength. In more severe grade deformities or when a vertebra is collapsed, OVF diagnosis can be made with a relatively high degree of certainty by experienced readers. In “milder” cases, OVF is often diagnosed based on a high probability rather than an absolute diagnosis. After excluding known mimickers, singular vertebral wedging in older women is statistically most likely an OLVF. For older women, three non-adjacent minimal grade OLVF (< 20% height loss), one minimal grade OLVF and one mild OLVF (20–25% height loss), or one OLVF with ≥ 25% height loss, meet the diagnosis of osteoporosis. For older men, a single OLVF with < 40% height loss may be insufficient to suggest the subject is osteoporotic. Common OLVF differential diagnoses include X-ray projection artifacts and scoliosis, acquired and developmental short vertebrae, osteoarthritic wedging, oncological deformities, deformity due to high-energy trauma VF, lateral hyperosteogeny of a vertebral body, Cupid’s bow, and expansive endplate, among others.
Using telemetry data and the sea ice satellite record to identify vulnerabilities in critical moult habitat for emperor penguins in West Antarctica
Authors: Trathan Philip N. , Wienecke Barbara , Fleming Andrew , Ireland Louise 
Published: April 2024

AbstractWe tracked adult emperor penguins from Rothschild Island, west Antarctic Peninsula in 2015/2016 during a summer with extensive sea ice of long duration, contrasting with past years of reduced sea ice extent associated with the recent, rapid, warming trend across the region. We fitted ARGOS PTT devices to penguins of unknown breeding status. Of 33 penguins tracked, nine returned to the colony, presumably to provision offspring. Their foraging trips lasted 9.6 ± 3.7 days, with maximum distances of 75 ± 45 km from the colony within coastal waters. Also, 18 instruments transmitted until the initiation of the annual moult. Penguins travelled at ~ 2.3 km h−1 before slowing for moult. Post-moult, some devices continued to transmit, with speeds of ~ 0.8 km h−1, plausibly due to ice drift, which is rapid in this region. Penguins remained within the seasonal sea ice throughout, staying within 100 km of land, and generally within 5 to 10 km of features (open water, polynyas, leads, icebergs) that offered potential access to the ocean. Penguins were unlikely to have been constrained by the extensive sea ice habitat in 2015/2016. Similar habitats would also have been available in most years of the satellite record (since 1979); however, the moult locations in 2015/2016 would not have been available in many years, and penguins would have needed to find alternative moult locations during some years. Despite uncertainties, the moult period is a critical time for emperor penguins, particularly as sea ice declines, potentially affecting adult survival.
Cotrimoxazole and targeted antibiotic prophylaxis for transrectal prostate biopsy: a single-center study
Authors: Jahnen Matthias , Amiel Thomas , Kirchoff Florian , Büchler Jacob W. , Herkommer Kathleen , Rothe Kathrin , Meissner Valentin H. , Gschwend Jürgen E. , Lunger Lukas 
Published: April 2024

Abstract
Purpose
The recent restriction on the use of fluoroquinolones for prophylaxis by the European Commission has left a gap in clear recommendations for practical antibiotic prophylaxis (PAP) for transrectal prostate biopsy (TRPB). This analysis investigated the viability of cotrimoxazole for PAP in TRPB.

Methods
This analysis included n = 697 patients who underwent TRPB for suspected prostate cancer (PCa). All patients received either empiric PAP with four doses of cotrimoxazole 960 mg or targeted antibiotic prophylaxis in case of a positive rectal or urine screening for multiresistant gram-negatives. Infectious complications after TRPB, microbiological findings, and clinical characteristics were evaluated. A multivariable logistic regression model was calculated to identify variables associated with infectious complications.

Results
Of the cohort, 86% (600/697) received PAP with cotrimoxazole, 1% (8/697) received cotrimoxazole plus an additional antibiotic, 4% (28/697) received amoxicillin + clavulanic acid, 4% (28/697) received fluoroquinolones, and 5% (33/697) received a single shot intravenous antibiotic prophylaxis with meropenem or piperacillin + tazobactam due to multiresistant microbiological findings in either pre-interventional urine culture or rectal swab. Infectious complications occurred in 2.6% (18/697) of patients. Fever was noted in 89% (16/18) of cases. Inpatient treatment was given to 67% (12/18) of affected patients, with 38% (7/18) having positive blood cultures, identifying cotrimoxazole-resistant E. coli strains in six out of seven cases. Multivariable logistic regression analysis revealed no clinically significant variables, including PAP with cotrimoxazole, as independent risk factors for an infectious complication.

Conclusions
Using cotrimoxazole as PAP for TRPB in cases without multiresistant gram-negatives in pre-interventional urine cultures or rectal swabs seems feasible and practical.
Do high-protein diets have the potential to reduce gut barrier function in a sex-dependent manner?
Authors: James Daniel , Poveda Carlos , Walton Gemma E. , Elmore J. Stephen , Linden Brandon , Gibson John , Griffin Bruce A. , Robertson M. Denise , Lewis Marie C. 
Published: April 2024

Abstract
Purpose
Impaired gut barrier function is associated with systemic inflammation and many chronic diseases. Undigested dietary proteins are fermented in the colon by the gut microbiota which produces nitrogenous metabolites shown to reduce barrier function in vitro. With growing evidence of sex-based differences in gut microbiotas, we determined whether there were sex by dietary protein interactions which could differentially impact barrier function via microbiota modification.

Methods
Fermentation systems were inoculated with faeces from healthy males (n = 5) and females (n = 5) and supplemented with 0.9 g of non-hydrolysed proteins sourced from whey, fish, milk, soya, egg, pea, or mycoprotein. Microbial populations were quantified using fluorescence in situ hybridisation with flow cytometry. Metabolite concentrations were analysed using gas chromatography, solid phase microextraction coupled with gas chromatography-mass spectrometry and ELISA.

Results
Increased protein availability resulted in increased proteolytic Bacteroides spp (p < 0.01) and Clostridium coccoides (p < 0.01), along with increased phenol (p < 0.01), p-cresol (p < 0.01), indole (p = 0.018) and ammonia (p < 0.01), varying by protein type. Counts of Clostridium cluster IX (p = 0.03) and concentration of p-cresol (p = 0.025) increased in males, while females produced more ammonia (p = 0.02), irrespective of protein type. Further, we observed significant sex-protein interactions affecting bacterial populations and metabolites (p < 0.005).

Conclusions
Our findings suggest that protein fermentation by the gut microbiota in vitro is influenced by both protein source and the donor’s sex. Should these results be confirmed through human studies, they could have major implications for developing dietary recommendations tailored by sex to prevent chronic illnesses.