bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluation of moisture‐induced damage on the fatigue life of asphalt mixtures using failure tests of asphalt binders, interfaces, and mixtures
Authors: Silva Lucas Sassaki Vieira da , Bastos Juceline Batista dos Santos , Lucas Júnior Jorge Luiz Oliveira , Babadopulos Lucas Feitosa de Albuquerque Lima , Soares Jorge Barbosa 
Published: April 2024

AbstractFatigue cracking, a major distress in asphalt pavements, is worsened by traffic and climate conditions such as moisture effects on constituents and interfacial properties. However, investigation on fatigue's evolution in different scales under moisture effect is still scarce in the open literature. This work aims to assess moisture‐induced damage effects on asphaltic materials focusing on the failure of asphalt binders, the aggregate‐binder interface, and mixture. The methodology included tests under dry and wet conditions: linear amplitude sweep (LAS); asphalt bond strength (ABS) in different temperatures and pull rates for interfaces; indirect tensile strength (ITS), and tension‐compression fatigue on asphalt mixtures. Key findings were: (i) moisture damage presents growing effects from binders to mixtures; (ii) LAS test results were not sensitive to moisture; (iii) ABS tests require proper field temperatures for accuracy; (iv) ITS ratio provide reliable conditioned fatigue expectations; and (v) fatigue testing without conditioning to hydrodynamic effects or real moisture susceptibility might overestimate service‐life.
Forage accumulation, nutritive value, and grazing efficiency on rotationally stocked ‘Zuri’ guineagrass pastures as affected by pre‐graze canopy height and N rate
Authors: de Almeida Otávio Goulart , Pedreira Carlos Guilherme Silveira , de Assis Juliana Aparecida , da Silva Valdson José , Pedreira Bruno Carneiro e 
Published: April 2024

AbstractGrazing management and nitrogen fertilisation may affect forage accumulation (FA), nutritive value, and grazing efficiency (GE) of the highly productive ‘Zuri’ guineagrass [Megathyrsus maximus (Jacq.) B.K.Simon & S.W.L. Jacobs syn. Panicum maximum Jacq.]. The objective of this study was to assess the effects of pre‐graze canopy heights [55 and 75 cm (H55 and H75, respectively)] and N fertilisation rates [150 and 300 kg N ha−1 year−1 (N150 and N300, respectively)] on FA, GE, grazing losses (GL), and nutritive value of Zuri under rotational stocking. The stubble height was 50% of the pre‐graze canopy height. The total FA was 20% greater under H75 than H55 (22,120 vs. 18,370 kg DM ha−1 year−1), as well as the GL was greater under H75 (85%) than under H55 (79%). Regardless of pre‐graze height, the upper stratum of the canopy was composed mostly of leaves contributing to similar crude protein (CP) (142 g kg−1) and in vitro digestible organic matter (IVDOM) (559 g kg−1) concentrations. Greater N rate (N300) increased FA (23,500 vs. 16,980 kg DM ha−1 year−1) and resulted in greater GE (84% vs. 80%) compared to N150. The CP and IVDOM concentrations under N300 (157 and 571 g kg−1, respectively) were greater than under N150 (128 and 547 g kg−1). Zuri guineagrass grazed at H75 has great FA and GE, maintaining a similar forage nutritive value compared to H55.
The Role of Rotated Potential Mixing Protocols on the Behavior of a Conservative Reagent
Authors: Cho Michelle S. , Thomson Neil R. 
Published: April 2024

AbstractChaotic advection is defined as the generation of “small‐scale structures” from the repeated stretching and folding of fluid elements in a laminar flow regime that has the potential to enhance mixing and improve treatment effectiveness. Rotated potential mixing (RPM) flow is one configuration used to invoke chaotic advection and involves periodically re‐oriented dipole flow through the transient switching of pressures at a series of radial wells. In this study, we relied on conventional models used by remediation practitioners to represent the expected flow and transport behavior of a conservative reagent subjected to chaotic advection by an RPM flow system, and then explored the impact of engineering controls on reagent mixing behavior. The various lines of evidence demonstrated that this modeling approach captured the key features of the expected transport behavior reported in other studies. Visual observations of the reagent distribution, and quantitative metrics of mixing behavior highlighted the different responses that are possible by the various combinations of RPM flow parameters explored. The results show the importance of combining theoretical considerations with practical limitations when designing an RPM flow system. The flow rate and pumping duration have direct consequences on the degree of reagent spreading and mixing. The use of the same RPM flow protocol in a heterogeneous K field led to a significantly greater degree of reagent mixing than in a homogeneous K system. The results from this investigation have important implications for the design of RPM flow protocols to promote enhanced reagent mixing and thereby improve treatment effectiveness.
Vat photopolymerization 3D printing of Al2O3 ceramic cores with strip‐shaped pores by using polyamide 6 fiber template
Authors: Zhai Xiaofei , Chen Jingyi , Su Ruyue , Gao Xiong , Zhang Xueqin , He Rujie 
Published: April 2024

AbstractThe complex ceramic core used for hollow turbine blades requires high porosity and flexural strength. This work combined vat photopolymerization 3D printing with sacrificial template method to prepare Al2O3 ceramic cores with strip‐shaped pores using polyamide 6 (PA6) fibers as templates. When the porosity was greater than 30%, the maximum flexural strength reached up to 110.48 MPa. The sacrificial templating method improved the porosity of Al2O3 ceramic cores, forming an internal porous structure that combined strip‐shaped large pores with irregularly shaped small pores. The influences of PA6 fiber content and diameter on the shrinkage, porosity, microstructure, and comprehensive properties of alumina ceramic cores were studied, revealing the mechanism of the coexistence of high porosity and high strength.
Comparative clinical evaluation between self‐adhesive and conventional bulk‐fill composites in class II cavities: A 1‐year randomized controlled clinical study
Authors: Ellithy Mohamed S. , Abdelrahman Mohamed H. , Afifi Rania R. 
Published: April 2024

AbstractObjectiveThis randomized controlled clinical trial compared the clinical efficacy of self‐adhesive bulk‐fill Surefil One with a traditional bulk‐fill composite in class II restorations.Materials and MethodsSixty‐four direct class II composite restorations were categorized into two groups. Group I, control group (n = 32): cavities were restored by Filtek One bulk‐fill composite with Scotchbond Universal (SBU) adhesive in self‐etch mode, Group II, test group (n = 32): cavities were restored by Surefil One self‐adhesive bulk‐fill composite. The study involved a follow‐up period of 1 year, during which restorations were assessed at baseline (BL), 6 months, and 12 months using Federation Dentaire Internationale (FDI) criteria. Data analysis was performed using nonparametric tests. A comparison of restoration characteristics was performed utilizing the chi‐square test (X2). The significance level was set at 0.05.ResultsFiltek One and Surefil One bulk‐fill composites revealed clinically acceptable FDI scores over 12‐month recalls. Thirty‐two patients (64 restorations) were available for all follow‐up visits; 100% of the restorations survived. For esthetic properties, Filtek One was far better than Surefil One at all time points. However, in terms of functional and biological properties, both restorations demonstrated comparable performances.ConclusionsFiltek One bulk‐fill restorations were superior in terms of surface luster, surface staining, color match, and translucency, but Surefil One restorations performed well and were similar to Filtek One restorations; however, additional advancements and research are needed to obtain better esthetics. Furthermore, longitudinal studies with extended follow‐up periods are needed to assess the clinical potential of both materials.Clinical SignificanceBoth Filtek One and Surefil One met the FDI criteria, with Filtek One demonstrating superior esthetic and functional qualities and similar performance regarding biological criteria. Both innovative restorative materials show potential for clinical use. Trial registered on ClinicalTrials.gov under registration number; NCT06120868:07/11/2023.
Characterization of sound production by the pot‐bellied seahorse (Hippocampus abdominalis) during feeding
Authors: Romanchek Brittany A. H. , Uetz George , Scheifele Peter M. 
Published: April 2024

AbstractSound production during feeding by the pot‐bellied seahorse, Hippocampus abdominalis, was quantified with an observation of clicks (acoustic signal) and snicks (visual behavior). Female, male, and juvenile seahorses had feeding sounds characterized for peak (dominant) frequency (Hz), sound pressure level (SPL), and duration (ms). Subject body size and condition was estimated by standard length (SL, cm), to determine an estimate of body condition index (BCI). An inverse correlation between mean peak frequency (Hz) of clicks and SL was found for females. A negative correlation between peak frequency (Hz) of clicks and a residual BCI was determined for both males and females, suggesting that acoustic signals may contain information regarding fitness.
The incorporation of strontium and barium into the otoliths of the flounder Paralichthys olivaceus at early life stages demonstrates resilience to ocean acidification
Authors: Tian Honglin , Liu Jinhu , Shan Xiujuan , Cao Liang , Jin Xianshi , Dou Shuozeng 
Published: April 2024

AbstractOcean acidification could modify the bioavailability and chemical properties of trace elements in seawater, which could affect their incorporation into the calcareous structures of marine organisms. Fish otoliths, biomineralized ear stones made by aragonite, are suspended within the endolymph fluid of teleosts, indicating that the elemental incorporation of otoliths might also be susceptible to ocean acidification. In this study, we evaluated the combined effects of CO2‐induced ocean acidification (pH 8.10, 7.70, and 7.30, corresponding to ocean acidification scenarios under the representative concentration pathway 8.5 model as projected by the Intergovernmental Panel on Climate Change) and water elemental concentrations of strontium (Sr) and barium (Ba; low, medium, and high) on elemental incorporation into otoliths of the flounder Paralichthys olivaceus at early life stages. Our results revealed that the elemental incorporation of Sr and Ba into otoliths was principally dependent on the corresponding water elemental concentrations rather than on ocean acidification. Moreover, the partition coefficients (DMe) of Sr and Ba may stabilize after dynamic equilibrium is reached as the water elemental concentration increases, but are not affected by ocean acidification. Therefore, the incorporation of Sr and Ba into otoliths of the flounder at early life stages may not serve as an effective indicator of ocean acidification. In other words, the findings suggest that ocean acidification does not impact the incorporation of Sr and Ba incorporation into otoliths when tracing the temperature or salinity experiences of the flounder. Our findings will provide new knowledge for understanding the potential ecological effects of ocean acidification on the recruitment dynamics of fish species.
PANoptosis induced by inflammatory cytokines promotes salivary glands radiation injury
Authors: Qu Yi , Li Dan , Chen Guanzheng , Zhao Shuqi , Han Zhengxue , Qin Lizheng 
Published: April 2024

AbstractObjectiveSalivary glands are frequently damaged in patients undergoing radiotherapy for head and neck cancer. Whether PANoptosis, which is characterized by pyroptosis, apoptosis, and necroptosis, occurs during radiation injury to the salivary glands and its role remain unclear.Materials and MethodsRadiation‐induced injury models of mouse submandibular gland, as well as primary acinar cells and HSG cell lines were established to determine the presence of radiation‐induced PANoptosis. Several programmed cell death inhibitors, PFTα, disulfiram, Nec‐1 and zVAD, were used to compare the effects of different cell death pathway on radiation injury. The LEGENDplex™ Human Inflammation Panel was used to characterize the inflammatory landscape secreted by salivary gland cells after radiotherapy.ResultsSingle 15Gy or 8Gy radiotherapy triggered PANoptosis in mouse submandibular gland or salivary gland cells. Compared to the suppression of pyroptosis, apoptosis, or necroptosis alone, the inhibition of PANoptosis is more effective in preventing radiation injury to the salivary glands (p < 0.0001). The levels of multiple inflammatory cytokines were significantly up‐regulated in the supernatants of HSG cells within 48 h after IR. Neutralizing inflammatory cytokines are capable of inhibiting salivary glands PANoptosis.ConclusionsInhibition of PANoptosis induced by inflammatory cytokines can effectively prevent radiation injury of salivary glands.
Knowing with
Authors: Rabenberg Heather 
Published: April 2024

AbstractIn this paper, I argue that there are irreducibly social epistemic values alongside more traditional epistemic values such as knowledge and true belief. In particular, I argue that what I call “epistemic convergence” is one such value, and that it can help us explain the badness of social epistemic pathologies, such as testimonial injustice and epistemic bubbles.
Going above and beyond: Motivations of L2 German learners to (dis)continue language study
Authors: Wadas Megan , Goetze Julia , Jackson Carrie 
Published: April 2024

AbstractSecond‐language (L2) learner motivation has been a thriving subfield within L2 acquisition research for decades, particularly since the development of the L2 Motivational Self System (L2MSS), a multi‐faceted motivational theory. This survey‐based study examines (1) whether L2MSS facets differ between students intending to continue (or discontinue) learning German past the language requirement and (2) whether any relationship exists between the different selves within the L2MSS, students’ L2 Learning Experience (L2E), and their Willingness to Communicate (WTC). Third‐semester learners’ mean ratings of their Ideal Self, Anti‐Ought‐To Self, WTC, and Attitudes Toward the L2 Community were significantly higher among students intending to continue German study beyond the language requirement (N = 28) than those discontinuing study (N = 46). Multiple regression analyses predicted a positive effect of the Ideal Self on ratings of both L2E and WTC. Qualitative analysis revealed themes of fear and positive attitudes toward the German language/culture among learners intending to continue German study, while non‐continuers predominantly mentioned the language requirement. Both continuers and non‐continuers mentioned the concrete and abstract utility of language learning as an additional motivation. The implications of these results for student recruitment and retention in German language programs are discussed.
Considerations for performing companion animal skin microbiome studies
Authors: Older Caitlin E. , Rodrigues Hoffmann Aline 
Published: April 2024

AbstractThe microbiome field has grown significantly in the past decade, and published studies have provided an overview of the microorganisms inhabiting the skin of companion animals. With the continued growth and interest in this field, concerns have been raised regarding sample collection methods, reagent contamination, data processing and environmental factors that may impair data interpretation (especially as related to low‐biomass skin samples). In order to assure transparency, it is important to report all steps from sample collection to data analysis, including use of proper controls, and to make sequence data and sample metadata publicly available. Whilst interstudy variation will continue to exist, efforts to standardise methods will reduce confounding variables, and allow for reproducibility and comparability of results between studies. Companion animal microbiome studies often include clinical cases, and small sample sizes may result in lack of statistical significance within small datasets. The ability to combine results from standardised studies through meta‐analyses would mitigate the limitations of these smaller studies, providing for more robust interpretation of results which could then inform clinical decisions. In this narrative review, we aim to present considerations for designing a study to evaluate the skin microbiome of companion animals, from conception to data analysis.
Schirmer tear test‐1 with open or closed eyelids: An evaluation in brachycephalic and nonbrachycephalic dogs
Authors: Pe'er Oren , Ofri Ron , Sebbag Lionel 
Published: April 2024

AbstractPurposeAssess aqueous tear production when measured with the dogs' eyelids open or closed.MethodsThirty healthy dogs (15 Shih Tzus, 15 Labrador retrievers) were recruited. With the order of testing randomized for each dog, two sessions (separated by 30 min) of STT‐1 testing were performed with the dogs' eyelids closed or open. Schirmer strip wetness (every 10 s for 60 s) and number of time(s) the strip dislodged during testing were recorded in each eye. Preferred STT‐1 method was surveyed via a global Listserv of the veterinary ophthalmology community.ResultsSTT‐1 values were significantly higher in closed versus open eyes in Shih Tzus (18.6 ± 2.7 mm/min vs. 16.3 ± 2.5 mm/min; p = .002) and Labrador retrievers (21.6 ± 2.9 mm/min vs. 17.8 ± 3.2 mm/min, p < .001), findings that were also significant at times <60 s for either breed (p ≤ .004). Schirmer strips dislodged from six dogs with open eyelids and no dogs with closed eyelids. Maximal STT‐1 difference with closed versus open eyelids was 13 mm/min in Labrador retrievers and 7 mm/min in Shih Tzus. Survey results from 275 veterinarians showed STT‐1 performed with “closed eyelids” (38.5%), “open eyelids” (26.9%), or “never paid attention, sometimes closed, sometimes open” (34.6%).ConclusionsEyelids status (closed or open) during STT‐1 testing had a significant impact on aqueous tear secretion in brachycephalic and nonbrachycephalic dogs, highlighting the importance of consistency when repeating STT‐1 in a canine patient. STT‐1 differences are likely due to sustained reflex tearing throughout the test duration when the dogs' eyelids are closed.
Fekete-Szegӧ Functional for Classes X_q^n (φ) and Y_q^n (φ)
Authors: Tseu Suet Yie , Janteng Aini 
Published: April 2024

Two new subclasses of analytic functions are proposed by applying q-differential operator which is denoted as . Throughout this study, we acquired the initial coefficients and and the upper bound for the functional of the functions in the classes and .
Intentional Blade Mistuning to Emulate the Dynamic Influence of Split Ring Damper
Authors: Lee Jaewon , Baek Seunghun 
Published: April 2024

Abstract
A novel methodology to predict responses of bladed disks incorporated with a split ring damper is proposed. To account for the dynamic characteristics of a split ring damper, intentional blade stiffness mistuning is presented. It is assumed that the mistuning is proportional to the blade stiffness matrix and uniformly distributed to all blades. Therefore, responses of bladed disks integrated with a split ring damper are captured by the detuned bladed disk integrated with a continuous ring damper. The proposed method is demonstrated through a lumped parameter model and validated using a complete finite element model. A key advantage of the proposed approach is that the dynamic characteristics of a split ring damper are emulated by a continuous ring damper in the detuned bladed disk. Moreover, the approach holds the potential to facilitate reduced-order modeling (ROM) by employing sector-level calculations. This results in substantial reductions in computational efforts while maintaining accurate predictions of forced responses.
From Research to Application of Wearable-Derived Digital Health Measures—A Perspective From ActiGraph
Authors: Wyatt Jeremy , Guo Christine C. 
Published: April 2024

ActiGraph counts were first conceptualized in 1996 to provide an accelerometer-derived metric that can quantify physical activity based on intensity. ActiGraph incorporated this metric into its product suite, enabling its wide adoption in research studies. Over the last 20 years, ActiGraph activity counts have become one of the most common metrics and building blocks of health outcome measures used in wearable research, with >24,000 journal articles published (based on Google Scholar search in 2023). Recently, this field of research is increasingly moving toward clinical application where wearable-derived metrics are growing in industry-sponsored clinical trials, including several use cases endorsed by the regulatory authorities. We celebrate this emerging trend as these patient-generated measures help reduce trial burden and enhance the meaningfulness of developed medical products to the patients. However, true adoption of digital measures in industry research is only in its infancy and still faces many challenges. As a digital health technology provider, ActiGraph has launched several strategic initiatives to support the research community to overcome these challenges and accelerate the translation of research to clinical application. The open-source release of the ActiGraph count algorithm was one of those initiatives. In this commentary, we take the opportunity to share our perspective in supporting the research community with this metric over the last 20 years, the motivation for making this open source, and what we are building to accelerate clinical adoption and realize the promise of better patient care.
How to use meropenem in pediatric patients undergoing CKRT? Integrated meropenem pharmacokinetic model for critically ill children
Authors: Butragueño-Laiseca Laura , Troconiz Iñaki F. , Grau Santiago , Campillo Nuria , Padilla Belén , Fernández Sarah Nicole , Slöcker María , Herrera Laura , Santiago María José 
Published: April 2024

ABSTRACT

Standard dosing could fail to achieve adequate systemic concentrations in ICU children or may lead to toxicity in children with acute kidney injury. The population pharmacokinetic analysis was used to simultaneously analyze all available data (plasma, prefilter, postfilter, effluent, and urine concentrations) and provide the pharmacokinetic characteristics of meropenem. The probability of target fT > MIC attainment, avoiding toxic levels, during the entire dosing interval was estimated by simulation of different intermittent and continuous infusions in the studied population. A total of 16 critically ill children treated with meropenem were included, with 7 of them undergoing continuous kidney replacement therapy (CKRT). Only 33% of children without CKRT achieved 90% of the time when the free drug concentration exceeded the minimum inhibitory concentration (%fT > MIC) for an MIC of 2 mg/L. In dose simulations, only continuous infusions (60–120 mg/kg in a 24-h infusion) reached the objective in patients <30 kg. In patients undergoing CKRT, the currently used schedule (40 mg/kg/12 h from day 2 in a short infusion of 30 min) was clearly insufficient in patients <30 kg. Keeping the dose to 40 mg/kg q8h without applying renal adjustment and extended infusions (40 mg/kg in 3- or 4-h infusion every 12 h) was sufficient to reach 90% fT > MIC (>2 mg/L) in patients >10 kg. In patients <10 kg, only continuous infusions reached the objective. In patients >30 kg, 60 mg/kg in a 24-h infusion is sufficient and avoids toxicity. This population model could help with an individualized dosing approach that needs to be adopted in critically ill pediatric patients. Critically ill patients subjected to or not to CKRT may benefit from the administration of meropenem in an extended or continuous infusion.