bluuebunny/crossref_metadata_2025_split huggingface dataset:
Lessons learned from COVID-19: improving breast cancer care post-pandemic from the patient perspective
Authors: Myers Charlotte , Bennett Kathleen , Cahir Caitriona 
Published: May 2024

Abstract
Background
Since the onset of the pandemic, breast cancer (BC) services have been disrupted in most countries. The purpose of this qualitative study is to explore the unmet needs, patient-priorities, and recommendations for improving BC healthcare post-pandemic for women with BC and to understand how they may vary based on social determinants of health (SDH), in particular socio-economic status (SES).

Methods
Thirty-seven women, who were purposively sampled based on SDH and previously interviewed about the impact of COVID-19 on BC, were invited to take part in follow-up semi-structured qualitative interviews in early 2023. The interviews explored their perspectives of BC care since the easing of COVID-19 government restrictions, including unmet needs, patient-priorities, and recommendations specific to BC care. Thematic analysis was conducted to synthesize each topic narratively with corresponding sub-themes. Additionally, variation by SDH was analyzed within each sub-theme.

Results
Twenty-eight women (mean age = 61.7 years, standard deviation (SD) = 12.3) participated in interviews (response rate = 76%). Thirty-nine percent (n = 11) of women were categorized as high-SES, while 61% (n = 17) of women were categorized as low-SES. Women expressed unmet needs in their BC care including routine care and mental and physical well-being care, as well as a lack of financial support to access BC care. Patient priorities included the following: developing cohesion between different aspects of BC care; communication with and between healthcare professionals; and patient empowerment within BC care. Recommendations moving forward post-pandemic included improving the transition from active to post-treatment, enhancing support resources, and implementing telemedicine where appropriate. Overall, women of low-SES experienced more severe unmet needs, which in turn resulted in varied patient priorities and recommendations.

Conclusion
As health systems are recovering from the COVID-19 pandemic, the emphasis should be on restoring access to BC care and improving the quality of BC care, with a particular consideration given to those women from low-SES, to reduce health inequalities post-pandemic.
The development of sensitive graphene-based surface acoustic wave sensors for NO2 detection at room temperature
Authors: Buiculescu Valentin , Dinu Livia Alexandra , Veca Lucia Monica , Pârvulescu Cătălin , Mihai Madalina , Brîncoveanu Oana , Comănescu Florin , Brașoveanu Costin , Stoian Marius , Baracu Angela Mihaela 
Published: May 2024

AbstractBilayer graphene (Bl-Gr) and sulphur-doped graphene (S-Gr) have been integrated with LiTaO3 surface acustic wave (SAW) sensors to enhance the performance of NO2 detection at room temperature. The sensitivity of the Bl-Gr SAW sensors toward NO2, measured at room temperature, was 0.29º/ppm, with a limit of detection of 0.068 ppm. The S-Gr SAW sensors showed 0.19º/ppm sensitivity and a limit of detection of 0.140 ppm. The origin of these high sensitivities was attributed to the mass loading and elastic effects of the graphene-based sensing materials, with surface changes caused by the absorption of the NO2 molecules on the sensing films. Although there are no significant differences regarding the sensitivity and detection limit of the two types of sensors, the measurements in the presence of interferent gases and various humidity conditions outlined much better selectivity and sensing performances towards NO2 gas for the Bl-Gr SAW sensors.
Graphical Abstract
Plant-based zinc nanoflowers assisted molecularly imprinted polymer for the design of an electrochemical sensor for selective determination of abrocitinib
Authors: Cetinkaya Ahmet , Yusufbeyoglu Sadi , Kaya S. Irem , Kilic Ayse Baldemir , Atici Esen Bellur , Ozkan Sibel A. 
Published: May 2024

AbstractThe first electrochemical sensor application in the literature is described for the sensitive and selective determination of the selective Janus kinase (JAK)-1 inhibitor abrocitinib (ABR). ABR is approved by the U.S. Food and Drug Administration (FDA) for the treatment of atopic dermatitis. The molecularly imprinted polymer (MIP)-based sensor was designed to incorporate zinc nanoflower (ZnNFs)-graphene oxide (GO) conjugate (ZnNFs@GO), synthesized from the root methanolic extract (RME) of the species Alkanna cappadocica Boiss. et Bal. to improve the porosity and effective surface area of the glassy carbon electrode (GCE). Furthermore, the MIP structure was prepared using ABR as a template molecule, 4-aminobenzoic acid (4-ABA) as a functional monomer, and other additional components. Scanning electron microscopy (SEM), X-ray diffraction (XRD), and Fourier transform infrared spectroscopy (FTIR) were used to characterize the surface and structure of the synthesized nanomaterial and MIP-based surface. Among the electrochemical methods, cyclic voltammetry (CV) and electrochemical impedance spectroscopy (EIS) were preferred for detailed electrochemical characterization, and differential pulse voltammetry (DPV) was preferred for all other electrochemical measurements using 5.0 mM [Fe(CN)6]3–/4– solution as the redox probe. The MIP-based sensor, which was the result of a detailed optimization phase, gave a linear response in the 1.0 × 10–13 – 1.0 × 10–12 M range in standard solution and serum sample. The obtained limit of detection (LOD) and limit of quantification (LOQ) values and recovery studies demonstrated the sensitivity, accuracy, and applicability of the sensor. Selectivity, the most important feature of the MIP-based sensor, was verified by imprinting factor calculations using ibrutinib, ruxolitinib, tofacitinib, zonisamide, and acetazolamide.
Graphical Abstract
Multilevel determinants of physical violence among ever-partnered women in South Africa
Authors: Puoeng Dikago , Tsawe Mluleki 
Published: May 2024

Abstract
Background
Violence against women continues to be a challenge in many countries. Many women suffer physical violence at the hands of their intimate partners and sometimes this leads to their deaths. This study aimed to examine the multilevel determinants of physical violence among ever-partnered women in South Africa.

Methods
We used data from the 2016 South Africa Demographic and Health Survey. The study has a weighted sample size of 4169 ever-partnered women aged 18–49 years, based on the domestic violence module. We included univariate, bivariate and multilevel logistic regression analysis. We included a two-level model to measure the relationship between the selected background characteristics and physical violence.

Results
The prevalence of physical violence among ever-partnered women was 20.6%. The bivariate findings showed that educational status, employment status, witness to inter-parental violence, partner’s drinking habits, household wealth, educational difference, and province were statistically associated with physical violence. The multilevel analysis showed some evidence of between-cluster variation in physical violence. We found that age, education, employment status, witness to inter-parental violence, partner’s drinking habits, household wealth, education difference, place of residence, and province were key predictors of physical violence. The odds of physical violence were more than two-fold in the Eastern Cape and Mpumalanga compared to Gauteng.

Conclusion
The study highlighted various key factors explaining physical violence. The findings suggest the need for targeted interventions aimed at specific communities of women, such as those from the Eastern Cape and Mpumalanga, as well as interventions that will empower women and address gender inequalities.
Plant-level establishment can result from a single female Acanthococcus lagerstroemiae propagule
Authors: Wright Erika R. , Chase Kevin D. , Ward Samuel F. 
Published: May 2024

AbstractCrapemyrtle bark scale (CMBS), Acanthococcus lagerstroemiae (Kuwana) (Hemiptera: Eriococcidae), is a non-native scale insect that has spread throughout many urban areas of the Southeast and Middle Atlantic regions of the United States following its initial detection near Dallas, Texas in 2004, severely reducing the aesthetic value and health of the popular ornamental crapemyrtle tree (Lagerstroemia spp.). We infested crapemyrtles with known numbers of CMBS to determine the minimum number of individuals required for establishment after initial arrival on plants. We also investigated how netting—implemented to understand differences in establishment when scale dispersal and predation are inhibited—influenced population growth. We determined that one female CMBS egg sac can successfully establish a new population ~ 92% of the time and that netting had negligible effects on establishment. Our results underscore the importance of surveying and managing CMBS and scale insects with similar biology when attempting to prevent infestation of nursery stock, which is widely implicated as a vector for long-distance dispersal of scale insects.
Canopy nitrogen application effects on Quercus petraea L. and Fagus sylvatica L. ring width and wood density
Authors: Minikaev Daniel , Ventura Maurizio , Tonon Giustino , Uhl Enno , Ravaioli Dario , Jankowski Przemysław A. , Wellstein Camilla 
Published: May 2024

AbstractAs an essential nutrient, Nitrogen (N) availability is fundamental in evaluating forest productivity, and as such, understanding the effects of changing atmospheric N inputs in forest ecosystems is of high significance. While most field experiments have been employing ground fertilization as a method to simulate N deposition, two experimental forest sites in Italy have adopted the more advanced canopy N application approach. Here we present findings from a case study of wood core analyses of predominantly pure, even aged, Sessile oak (Quercus petraea L.) and European beech (Fagus sylvatica L.) forest stands, treated with either below or above canopy N fertilization, comparing between the two simulation pathways of increased N deposition. The potential effects of elevated N availability on total ring width, mean ring density, and their corresponding earlywood and latewood fractions are examined. Our results indicate inconclusive effects of the treatments on the ring width traits of both Q. petraea or F. sylvatica, although basal area increment patterns appeared to be affected divergently between the species and treatments. Mean and earlywood, but not latewood, densities on the other hand, exhibited a decrease in certain years of the treatment period in Q. petraea as result of the above canopy N application only, whereas F. sylvatica wood density showed no clear response to any of the treatments. Thus, we are describing distinct reactions of the two broadleaved species to the different experimental N deposition approaches, discussing potential growth patterns under increased N availability, and emphasizing the importance of considering wood density in assessments of tree biomass accumulation and essentially Carbon storage capacities.
The media's coverage and framing of hospital reforms: The case of Germany
Authors: Berger Elke , Eriksen Astrid , Wiedicke Annemarie , Ortlepp Len , Caglar Robert , Busse Reinhard 
Published: May 2024

Abstract
Aim
In Germany, a long-lasting debate about the need for a hospital reform, including centralisation, now resulted in reform plans. As cutbacks to essential services such as hospitals are an emotional topic, the public should be properly informed, which is a central role of the media. Based on a media analysis of a large-scale hospital reform in Denmark, showing that the media’s reporting might have had an agenda-setting effect, we analysed the media’s coverage and framing of restructuring the hospital landscape in German newspapers.

Subject and methods
A systematic search identified relevant articles in national and regional newspapers. The coverage between January 2018 and January 2023 was analysed regarding quantity and main theme (agenda-setting). Each article’s title and main text were analysed for tone and whether it focused on episodic (single events) or thematic (broader context) framing.

Results
A total of 705 newspaper articles (592 regional, 113 national) were included. Both regional and national newspapers mainly used episodic framing. Regional newspapers mostly reported on single closures of hospitals or departments. The tone of the title and main text in national newspapers was mainly negatively depicted, which applied to less than half of the articles in regional newspapers. These differences were, however, not statistically significant.

Conclusion
Results indicate higher agenda-setting effects in regional compared to national newspapers. However, the overall high amount of episodic framing can result in less attribution of responsibility to policy-makers, thereby conserving the status quo. To succeed, a media strategy might help to raise problem awareness among the public.
Distinct roles of SOX9 in self-renewal of progenitors and mesenchymal transition of the endothelium
Authors: Zhao Jilai , Sormani Laura , Jacquelin Sebastien , Li Haiming , Styke Cassandra , Zhou Chenhao , Beesley Jonathan , Oon Linus , Kaur Simranpreet , Sim Seen-Ling , Wong Ho Yi , Dight James , Hashemi Ghazaleh , Shafiee Abbas , Roy Edwige , Patel Jatin , Khosrotehrani Kiarash 
Published: May 2024

AbstractRegenerative capabilities of the endothelium rely on vessel-resident progenitors termed endothelial colony forming cells (ECFCs). This study aimed to investigate if these progenitors are impacted by conditions (i.e., obesity or atherosclerosis) characterized by increased serum levels of oxidized low-density lipoprotein (oxLDL), a known inducer of Endothelial-to-Mesenchymal Transition (EndMT). Our investigation focused on understanding the effects of EndMT on the self-renewal capabilities of progenitors and the associated molecular alterations. In the presence of oxLDL, ECFCs displayed classical features of EndMT, through reduced endothelial gene and protein expression, function as well as increased mesenchymal genes, contractility, and motility. Additionally, ECFCs displayed a dramatic loss in self-renewal capacity in the presence of oxLDL. RNA-sequencing analysis of ECFCs exposed to oxLDL validated gene expression changes suggesting EndMT and identified SOX9 as one of the highly differentially expressed genes. ATAC sequencing analysis identified SOX9 binding sites associated with regions of dynamic chromosome accessibility resulting from oxLDL exposure, further pointing to its importance. EndMT phenotype and gene expression changes induced by oxLDL in vitro or high fat diet (HFD) in vivo were reversed by the silencing of SOX9 in ECFCs or the endothelial-specific conditional knockout of Sox9 in murine models. Overall, our findings support that EndMT affects vessel-resident endothelial progenitor’s self-renewal. SOX9 activation is an early transcriptional event that drives the mesenchymal transition of endothelial progenitor cells. The identification of the molecular network driving EndMT in vessel-resident endothelial progenitors presents a new avenue in understanding and preventing a range of condition where this process is involved.
Home-Visiting Programming in Kindergarten-Readiness Interventions: Retention and Loss of Families
Authors: Justice Laura M. , Jiang Hui , Planke Julie , Purtell Kelly , Pelfrey Logan , Dore Rebecca 
Published: May 2024

Abstract

Background
Home-visiting programs are an often-used intervention for supporting the well-being of families with young children, and there is long-standing interest among researchers in ensuring the effectiveness of this practice. Especially, retention and attrition play important roles in achieving desired outcomes of the intervention.

Objective
This study aims to examine home-visit participation levels among low-income families and explore correlates of the participation levels. It also aims to evaluate patterns of attrition over time and to investigate child and family characteristics that potentially contribute to completion of the program.

Methods
We examined data from 113 families whose children participated in a 15-month kindergarten-transition intervention. All families received supplemental home-visiting activities as a key component of the intervention, beginning at the start of preschool and extending through middle of kindergarten year.

Results
We found that, on average, families completed four out of nine planned home visits, with large dispersion in the number of visits completed. Survival analyses suggested that families who dropped out were most likely to do so at the beginning of the program, with 39% of caregivers maintained to the final visit. Participation in the home-visiting program was related to children’s age and race, as well as children’s academic skill levels.

Conclusion
Study findings have implications for the design and implementation of kindergarten-readiness initiatives targeting low-income families, especially in terms of advancing strategies to maintain families in longitudinal activities.
Perspectives and Experiences of Stakeholders on Self-Disclosure of Peers in Mental Health Services
Authors: Ben-Dor Inbar Adler , Kraus Eran , Goldfarb Yael , Grayzman Alina , Puschner Bernd , Moran Galia S. 
Published: May 2024

Abstract With the movement towards recovery-oriented mental health (MH) services, individuals with MH lived-experience are increasingly employed as peer providers (peers). Peers are unique in that they bring knowledge from experience and eye-level connection to service users that enhance the quality of services and humanize MH systems’ culture. In Israel, hundreds of peers are employed in various roles and settings across the MH system. However, peer integration into MH services faces challenges. One issue involves the use of self-disclosure (SD) in MH services which varies with explicitness across roles and settings. This study sought to understand perspectives and experiences regarding peers’ SD (use & sharing of knowledge from experience) among different stakeholders in MH health services. Six focus groups and 4 semi-structured interviews (N = 42) were conducted as a part of a larger international project (UPSIDES; ERC Horizon 2020, Moran et al., Trials 21:371, 2020). Data was transcribed verbatim and analyzed using thematic analysis. Four categories and 7 themes were identified regarding current perspectives and experiences with peers’ SD in MH organizations: (i) Restrained or cautious organizational approach to SD; (ii) Attitudes of peers to SD approach; (iii) The influence of designated peer roles on SD; and (iv) Unwarranted SD of peers working in traditional roles. The findings reveal that peers’ SD in MH services is a complex process. Organizational approaches were often controlling of non-designated peers’ SD practices; participants had diverse attitudes for and against peers’ SD; SD occurred according to personal preferences, specific peer role and the director’s approach to peers’ SD; Conflictual SD dilemmas emerged in relation to service users and staff. SD sometimes occurs unwarrantely due to ill mental health. The presence of peer-designated roles positively impacts peers' SD. We interpret the current mix of views and general conduct of peer SD practice in statutory MH services as related to three aspects: 1. The presence of a traditional therapeutic SD model vs. a peer SD model – with the former currently being dominant. 2. Insufficient proficiency and skill development in peers’ SD. 3. Stigmatic notions about peer SD among service users and staff. Together, these aspects interrelate and sometimes create a negative cycle create tension and confusion.A need to develop professionalism of peer SD in statutory services is highlighted alongside enhancing staff and service user acknowledgement of the value of peer SD. Developing peer-designated roles can positively impacts peer SD in MH statutory services. Training, support, and organizational interventions are required to further support for peer-oriented SD and the enhancement of a person-centered and recovery orientation of MH services.
Climate model selection via conformal clustering of spatial functional data
Authors: Villani Veronica , Romano Elvira , Mateu Jorge 
Published: May 2024

AbstractClimate model selection stands as a critical process in climate science and research. It involves choosing the most appropriate climate models to address specific research questions, simulating climate behaviour, or making projections about future climate conditions. This paper proposes a new approach, using spatial functional data analysis, to asses which of the 18 EURO CORDEX simulation models work better for predicting average temperatures in the Campania region (Italy). The method involves two key steps: first, using functional data analysis to process climate variables and select optimal models by a hierarchical clustering procedure; second, validating the chosen models by proposing a new conformal prediction approach to the anomalies associated to each cluster.
Dissolved trace elements and nutrients in the North Sea—a current baseline
Authors: Siems Anna , Zimmermann Tristan , Sanders Tina , Pröfrock Daniel 
Published: May 2024

AbstractPrimary production is an important driver of marine carbon storage. Besides the major nutrient elements nitrogen, phosphorus, and silicon, primary production also depends on the availability of nutrient-type metals (e.g., Cu, Fe, Mo) and the absence of toxicologically relevant metals (e.g., Ni, Pb). Especially in coastal oceans, carbon storage and export to the open ocean is highly variable and influenced by anthropogenic eutrophication and pollution. To model future changes in coastal carbon storage processes, a solid baseline of nutrient and metal concentrations is crucial. The North Sea is an important shelf sea, influenced by riverine, atmospheric, Baltic Sea, and North Atlantic inputs. We measured the concentrations of dissolved nutrients (NH4+, NO3−, PO43−, and SiO44−) and 26 metals in 337 water samples from various depths within the entire North Sea and Skagerrak. A principal component analysis enabled us to categorize the analytes into three groups according to their predominant behavior: tracers for seawater (e.g., Mo, U, V), recycling (e.g., NO3−, PO43−, SiO44−), and riverine or anthropogenic input (e.g., Ni, Cu, Gd). The results further indicate an increasing P-limitation and increasing anthropogenic gadolinium input into the German Bight.
Shipwrecks in the Azores and Global Navigation (Sixteenth to Nineteenth Centuries): An Overview
Authors: Bettencourt José 
Published: May 2024

AbstractThe strategic importance of the Azores Islands resulted in the formation of a vast post-medieval underwater cultural heritage, consisting of shipwrecks and anchorages. This paper will discuss the scientific potential of this heritage through a presentation of the main shipwreck sites, specifically focusing on two historic ports of the archipelago’s central group where archaeological activity has been particularly intense: Angra, on Terceira Island, and Horta, on Fayal Island. The former was the main port of call for Portuguese and Spanish navigation in the sixteenth and seventeenth centuries; the latter was an important Atlantic port for British navigation from the end of the seventeenth century onward and for American fleets during the nineteenth century.