bluuebunny/crossref_metadata_2025_split huggingface dataset:
Immunotherapy combined with antiangiogenic therapy as third‐ or further‐line therapy for stage IV non‐small cell lung cancer patients with ECOG performance status 2: A retrospective study
Authors: Li Shuo , Yu Ze‐Shun , Liu Hong‐Zhi , Li Shu‐Jing , Wang Ming‐Yue , Ning Fang‐Ling , Tian Li‐Jun 
Published: June 2024

AbstractBackgroundPatients with Eastern Cooperative Oncology Group performance status (ECOG PS) 2 probably cannot tolerate chemotherapy or other antitumor therapies. Some studies have reported that immunotherapy combined with antiangiogenic therapy is well‐tolerated and shows good antitumor activity. However, the efficacy of this combination as a later‐line therapy in patients with ECOG PS 2 is unclear. This study evaluated the effectiveness and safety of this combination strategy as third‐ or further‐line therapy in stage IV non‐small cell lung cancer (NSCLC) patients with ECOG PS 2.MethodsIn this retrospective study, patients treated with camrelizumab plus antiangiogenic therapy (bevacizumab, anlotinib, or recombinant human endostatin) were included. Objective response rate (ORR), disease control rate (DCR), progression‐free survival (PFS), overall survival (OS), quality of life (QOL) assessed by ECOG PS, and safety were analyzed.ResultsBetween January 10, 2019, and February 28, 2024, a total of 59 patients were included. The ORR was 35.6% (21/59) and the DCR was 86.4%. With a median follow‐up of 10.5 months (range: 0.7–23.7), the median PFS was 5.5 months (95% confidence interval [CI]: 3.8–7.3) and the median OS was 10.5 months (95% CI: 11.2–13.6). QOL was improved (≥1 reduction in ECOG PS) in 39 patients (66.1%). The most common Grade 3–4 treatment‐related adverse events were hepatic dysfunction (6 [10%]), hypertension (5 [8%]), and hypothyroidism (3 [5%]). There were no treatment‐related deaths.ConclusionsThird‐ or further‐line immunotherapy combined with antiangiogenic therapy is well‐tolerated and shows good antitumor activity in stage IV NSCLC patients with ECOG PS 2. Future large‐scale prospective studies are required to confirm the clinical benefits of this combination therapy.
Infraspecific Chemical Variability and Metabolomic Profiling by Paper Spray Ionization (PSI‐MS) of Averrhoa carambola from Different Brazilian Biomes
Authors: Balbino Naará S. , Lima Nerilson M. , Machado Hugo G. , Lima Gesiane S. , Sousa Jean C. P. , Gontijo Vaz Boniek 
Published: June 2024

AbstractThis research focused on the molecular diversity of A. carambola collected from three Brazilian biomes (Cerrado, Amazônia, and Mata Atlântica), whose results revealed significant differences in metabolite profiles among these biomes through PSI‐MS analysis. Chemometric analysis provided valuable insights into the clustering patterns and metabolic distinctions. Cerrado and Mata Atlântica biomes exhibited a 70 % similarity, indicating a notable degree of resemblance. In Cerrado, carambolaside A was notably abundant, while carambolaside M was low in Amazônia and moderate in Cerrado samples. Carambolaside B was abundant in Amazônia but relatively low in the Cerrado and Mata Atlântica. In contrast, the Amazônia biome samples appeared to be more dissimilar. In Cerrado, epicatechin, kaempferol, and procyanidin B showed lower abundance, while apigenin, quercetin, myricetin, and rutin displayed moderate levels. Mata Atlântica showed relatively higher levels of kaempferol, quercetin, and rutin. This study indicated the environmental influence on secondary metabolites production in A. carambola fruits.
Unveiling the culprit: Exploring malignant thrombotic superior vena cava obstruction
Authors: Yingchoncharoen Pitchaporn , Ashour Firas , Bernal Romelia Barba , Abdelnabi Mahmoud 
Published: June 2024

Key Clinical MessageThis case image describes the complex proposed etiologies of a case of superior vena cava syndrome. Hence, different diagnostic and therapeutic modalities are needed in a multidisciplinary team approach.
Rare Mullerian adenosarcoma of the uterine cervix arising on a background of endometriosis: A diagnostic challenge with risk of malignant transformation—A case report and review of the current literature
Authors: Bruguier Hannah , Maalouf Natalie , Smyth Sarah Louise , Damato Stephen , Reddy Priyanka , Soleymani majd Hooman 
Published: June 2024

Key Clinical MessageEndometriosis may contribute to Mullerian adenosarcoma development but makes diagnosis challenging given similar symptoms. Survival benefit has not been definitively shown for chemotherapy, hormonal therapy, or radiotherapy, consolidating surgery as the mainstay treatment. Local excision may be a treatment option for patients with confined tumors wishing to preserve their fertility.
Gastric metastasis of renal cell carcinoma treated with endoscopic resection: A case report
Authors: Yamashita Kaori , Kubota Satoshi , Sugiyama Harutoshi , Yoshida Keita , Shiseki Takahiro , Sakamoto Tetsushi , Nakazawa Tadao , Inui Masashi 
Published: June 2024

Key Clinical MessageGastric metastasis of renal cell carcinoma (RCC) is rarely encountered. The time interval between the primary diagnosis of RCC and the occurrence of gastric metastasis tends to occur after more than 10 years. Clinicians should be diligent in checking the general symptoms of patients for more than 10 years.
Visible Light‐promoted C(sp3)‐H α‐Carbamoylation of Cyclic Ethers with Isocyanides
Authors: Russo Camilla , Volpe Carmine , Santoro Federica , Brancaccio Diego , Di Porzio Anna , Carotenuto Alfonso , Randazzo Antonio , Grimaud Laurence , Vitale Maxime R. , Protti Stefano , Giustiniano Mariateresa 
Published: June 2024

AbstractA protocol exploiting isocyanides as carbamoylating agents for the α‐C(sp3)‐H functionalization of cyclic ethers has been optimized via a combined visible light‐driven hydrogen atom transfer/Lewis acid‐catalyzed approach. The isocyanide substrate scope revealed an exquisite functional group compatibility (18 examples, with yields up to 99 %). Both radical and polar trapping, kinetic isotopic effect and real‐time NMR studies support the mechanistic hypothesis and provide insightful details for the design of new chemical processes involving the generation of oxocarbenium ions.
A novel IFPWM‐based all‐digital transmitter architecture and FPGA implementation
Authors: Mehboob Rahman , Haque Muhammad Fahim Ul , Malik Tahir , Johansson Ted 
Published: June 2024

AbstractThe software‐defined radio (SDR) concept for wireless communications provides flexibility and simplicity, replacing most of the analog air interfaces. With all‐digital transmitters (ADT), the entire signal chain, from user input to frequency upconversion, can be implemented in the digital (programmable) domain, making it an ideal platform for SDR. ADTs depend heavily on the bitrate of the serializer to generate a specific frequency band with good Adjacent Channel Leakage Ratio (ACLR), however, the transmission frequency achieved is lower than half of the serializer's bitrate.In this paper, we present a scalable ADT architecture capable of generating higher transmission frequencies with state‐of‐the‐art comparable ACLR and relatively low implementation complexity. A modified Pulse‐Width Pulse‐Position Modulation (M‐PWPM) scheme, based on the RF‐PWM principle, is derived, which provides an improved ACLR and Error Vector Magnitude (EVM). The proposed transmitter architecture implemented on an Field‐Programmable Gate Array (FPGA) achieves ACLR of 32 dB and EVM below 2% at 14.72 GHz Tx frequency for a 20 MHz LTE signal. The obtained transmission frequency was achieved using a serializer operating at 28 Gbps, which is for the first time beyond the half of the serializer's bitrate. The proposed ADT architecture has the potential to be used with serializers beyond 28 Gbps bitrate, hence, achieving even higher transmission frequencies.
Magnetic properties of CrMnGen (n = 3–20) clusters
Authors: Wang Kai , Zhao Jun , Guo Junji , Chen Shanbao , Zhao Yapeng , Chen Jiaye , Wang Yarui , Liu Le , Wang Chaoyong , Liu Zhiqing 
Published: June 2024

AbstractDue to the potential applications in next‐generation micro/nano electronic devices and functional materials, magnetic germanium (Ge)‐based clusters are receiving increasing attention. In this work, we reported the structures, electronic and magnetic properties of CrMnGen with sizes n = 3–20. Transition metals (TMs) of Cr and Mn tend to stay together and be surrounded by Ge atoms. Small sized clusters with n ≤ 8 prefer to adopt bipyramid‐based structures as the motifs with the excess Ge atoms absorbed on the surface. Starting from n = 9, the structure with one TM atom interior appears and persists until n = 16, and for larger sizes n = 17–20, the two TM atoms are full‐encapsulated by Ge atoms to form endohedral structures. The Hirshfeld population analyses show that Cr atom always acts as the electron donor, while Mn atom is always the acceptor except for sizes 3 and 6. The average binding energies of these clusters increase with cluster size n, sharing a very similar trend as that of CrMnSin (n = 4–20) clusters, which indicates that it is favorable to form large‐sized clusters. CrMnGen (n = 6, 13, 16, 19, and 20) clusters prefer to exhibit ferromagnetic Cr–Mn coupling, while the remaining clusters are ferrimagnetic.
Long‐term follow‐up of patients treated with laser balloon for atrial fibrillation: A high volume center experience with the first‐ and second‐generation laser balloon
Authors: Urbanek Lukas , Bordignon Stefano , Tohoku Shota , Hirokami Jun , Nagase Takahiko , Chen Shaojie , Schaack David , Chun K. R. Julian , Schmidt Boris 
Published: June 2024

AbstractBackgroundLaser balloon (LB) pulmonary vein isolation (PVI) is an established ablation technique for atrial fibrillation (AF). We report long‐term follow‐up and procedural data of LB‐PVI and we compare the first and second LB generation.MethodsPatients undergoing LB ablation with first‐ (LB1) or second‐generation LB (LB2) for AF were retrospectively enrolled and divided into two groups. Procedural endpoint was complete PVI. Clinical success was defined as no recurrence of AF/atrial tachycardia after a 90 days blanking period.Results538 patients were included (age 66 ± 10 years, 58% paroxysmal AF), 427 in LB1 and 111 in LB2. 2079 PVs were targeted and 2073 (99.7%) were successfully isolated; 2027 (97.5%) using solely the LB. Additional touch‐up ablation was limited (46 PVs; 2.2%) with no difference between the groups. Procedural (LB1: 120 ± 33 minutes vs. LB2: 99 ± 22 min; p < .001) and fluoroscopy time (LB1: 11.2 ± 5 min vs. LB2: 8.5 ± 3 min; p < .001) were shorter with LB2. The complication rate was 8.9% (LB1: 10.1% vs. LB2: 4.5%; p = .067) with most complications resulting from the access site (21/48). Overall freedom from AF after 1‐year was 73.7% (paroxysmal AF: 76.9%; persistent AF: 69.3%; p < .001) with no difference between the groups (LB1: 73.4% vs. LB2: 74.7%; p = .491).ConclusionLB showed a high efficacy and acceptable safety, with numerically lower complication rates with the second‐generation LB. Procedure and fluoroscopy times were shorter with LB2. Overall, 73.7% of patients were free from AF at 1‐year, with comparable results among both generations.
Epyrifenacil, a new systemic PPO‐inhibiting herbicide for broad‐spectrum weed control
Authors: Sada Yoshinao , Jin Yoshinobu , Hikosaka Masashi , Ido Kunio 
Published: June 2024

AbstractEpyrifenacil is a novel PPO‐inhibiting herbicide discovered and developed by Sumitomo Chemical. Epyrifenacil belongs to the pyrimidinedione chemical class and has a unique three‐ring structure. It is systemically active on a broad range of weeds including grass weeds and some target‐site‐based PPO‐inhibitor resistant broadleaf weeds. Its systemic action is mediated by a phloem movement of the active form of epyrifenacil. In addition, epyrifenacil's vapor action is sufficiently low to not cause an off‐target movement to nontarget sensitive crops. It is expected that epyrifenacil will contribute to global food production in the near future. © 2024 The Author(s). Pest Management Science published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry.
Evaluating the technical use of a Fitbit during an intervention for patients with pulmonary arterial hypertension with quality of life as primary endpoint: Lessons learned from the UPHILL study
Authors: Kwant Chermaine T. , de Man Frances S. , Bogaard Harm J. , Vonk Noordegraaf Anton 
Published: June 2024

AbstractThis article examines technical use of Fitbit during an intervention for pulmonary hypertension (PAH)‐patients. Technical issues with the device led to data being unavailable(37.5%). During intervention objective daily physical activity (DPA) decreased and subjective DPA increased. This emphasizes that an assessment of DPA in PAH requires incorporating both objective and subjective measurements.
How are you, anthropology? Reflections on well‐being and the common good
Authors: Millhauser John K. 
Published: June 2024

AbstractThe articles that compose this special issue of Economic Anthropology represent a sample of the work presented and discussed at the 2023 annual meeting of the Society for Economic Anthropology on the topic of well‐being and the common good. I trace the roots of this conference theme in the midst of the COVID‐19 pandemic and its connections to the literature on the “anthropologies of the good.” I then unpack three themes that emerge across the articles in this special issue: the value of tacking between objective measures and subjective meanings, the productive tension produced by investigating across scales, and patterned variation from which we can build an anthropological theory of the good.
GeTe/MoTe2 Van der Waals Heterostructures: Enabling Ultralow Voltage Memristors for Nonvolatile Memory and Neuromorphic Computing Applications
Authors: Khot Atul C. , Nirmal Kiran A. , Dongale Tukaram D. , Kim Tae Geun 
Published: June 2024

AbstractAdvanced electronic semiconducting Van der Waals heterostructures (HSs) are promising candidates for exploring next‐generation nanoelectronics owing to their exceptional electronic properties, which present the possibility of extending their functionalities to diverse potential applications. In this study, GeTe/MoTe2 HS are explored for nonvolatile memory and neuromorphic‐computing applications. Sputter‐deposited Ag/GeTe/MoTe2/Pt HS cross‐point devices are fabricated, and they demonstrate memristor behavior at ultralow switching voltages (VSET: 0.15 V and VRESET: −0.14 V) with very low energy consumption (≈30 nJ), high memory window, long retention time (104 s), and excellent endurance (105 cycles). Resistive switching is achieved by adjusting the interface between the Ag top electrode and the heterojunction switching layer. Cross‐sectional transmission electron microscope images and conductive atomic force microscopy analysis confirm the presence of a conducting filament in the heterojunction switching layer. Further, emulating various synaptic functions of a biological synapse reveals that GeTe/MoTe2 HS can be utilized for energy‐efficient neuromorphic‐computing applications. A multilayer perceptron is implemented using the synaptic weights of the Ag/GeTe/MoTe2/Pt HS device, revealing high pattern accuracy (81.3%). These results indicate that HS devices can be considered a potential solution for high‐density memory and artificial intelligence applications.
FeSA‐Ir/Metallene Nanozymes Induce Sequential Ferroptosis‐Pyroptosis for Multi‐Immunogenic Responses Against Lung Metastasis
Authors: Yang Baochan , Cao Lingzhi , Ge Kun , Lv Chaofan , Zhao Zunling , Zheng Tianyu , Gao Shutao , Zhang Jinchao , Wang Tianyu , Jiang Jianzhuang , Qin Yan 
Published: June 2024

AbstractFor cancer metastasis inhibition, the combining of nanozymes with immune checkpoint blockade (ICB) therapy remains the major challenge in controllable reactive oxygen species (ROS) generation for creating effective immunogenicity. Herein, new nanozymes with light‐controlled ROS production in terms of quantity and variety are developed by conjugating supramolecular‐wrapped Fe single atom on iridium metallene with lattice‐strained nanoislands (FeSA‐Ir@PF NSs). The Fenton‐like catalysis of FeSA‐Ir@PF NSs effectively produced •OH radicals in dark, which induced ferroptosis and apoptosis of cancer cells. While under second near‐infrared (NIR‐II) light irradiation, FeSA‐Ir@PF NSs showed ultrahigh photothermal conversion efficiency (𝜂, 75.29%), cooperative robust •OH generation, photocatalytic O2 and 1O2 generation, and caused significant pyroptosis of cancer cells. The controllable ROS generation, sequential cancer cells ferroptosis and pyroptosis, led 99.1% primary tumor inhibition and multi‐immunogenic responses in vivo. Most importantly, the inhibition of cancer lung metastasis is completely achieved by FeSA‐Ir@PF NSs with immune checkpoint inhibitors, as demonstrated in different mice lung metastasis models, including circulating tumor cells (CTCs) model. This work provided new inspiration for developing nanozymes for cancer treatments and metastasis inhibition.
Dual‐Salts Localized High‐Concentration Electrolyte for Li‐ and Mn‐Rich High‐Voltage Cathodes in Lithium Metal Batteries
Authors: Wang Tianyang , Wan Ruichen , Tang Zhenghuan , Yap Jun Wei , Shao Jieren , Qin Lei , Zhang Songwei , Choi Junbin , Wu Yiying , Kim Jung‐Hyun 
Published: June 2024

AbstractLimited electrochemical stability windows of conventional carbonate‐based electrolytes pose a challenge to support the Lithium (Li)– and manganese (Mn)–rich (LMR) high‐voltage cathodes in rechargeable Li‐metal batteries (LMBs). To address this issue, a novel localized high‐concentration electrolyte (LHCE) composition incorporating LiPF6 and LiTFSI as dual‐salts (D‐LHCE), tailored for high‐voltage (>4.6 Vvs.Li) operation of LMR cathodes in LMBs is introduced. 7Li nuclear magnetic resonance and Raman spectroscopy revealed the characteristics of the solvation structure of D‐LHCE. The addition of LiPF6 provides stable Al‐current‐collector passivation while the addition of LiTFSI improves the stability of D‐LHCE by producing a more robust cathode‐electrolyte interphase (CEI) on LMR cathode and solid‐electrolyte interphase (SEI) on Li‐metal anode. As a result, LMR/Li cell, using the D‐LHCE, achieved 72.5% capacity retention after 300 cycles, a significant improvement compared to the conventional electrolyte (21.9% after 100 cycles). The stabilities of LMR CEI and Li‐metal SEI are systematically analyzed through combined applications of electrochemical impedance spectroscopy and distribution of relaxation times techniques. The results present that D‐LHCE concept represents an effective strategy for designing next‐generation electrolytes for high‐energy and high‐voltage LMB cells.
Enabling Gradient‐Structured Solid Electrolyte Interphase by a Hydrated Eutectic Electrolyte for High‐Performance Zn Metal Batteries
Authors: Li Ming , Zhu Xiaonan , Jiang Chenxu , Liu Xing , Li Zhen , Xu Gang , Wang Hongyong , Wu Minghong , Song Chan , Zhou Wenfeng , Wu Chao , Wang Guanyao 
Published: June 2024

AbstractAqueous Zn metal batteries are attracting tremendous interest as promising energy storage systems due to their intrinsic safety and cost‐effectiveness. Nevertheless, the reversibility of Zn metal anodes (ZMAs) is hindered by water‐induced parasitic reactions and dendrite growth. Herein, a novel hydrated eutectic electrolyte (HEE) consisting of Zn(BF4)2·xH2O and sulfolane (SL) is developed to prevent the side reactions and achieve the outstanding cyclability of ZMAs. The strong coordination between Zn2+ and SL triggers the eutectic feature, enabling the low‐temperature availability of HEEs. The restriction of BF4− hydrolysis in the eutectic system can realize favorable compatibility between Zn(BF4)2‐based electrolyte and ZMAs. Besides, the newly‐established solvation structure with the participation of SL, H2O, and BF4−, can induce in situ formation of desirable SEI with gradient structure consisting of B,O‐rich species, ZnS, and ZnF2, to offer satisfactory protection toward ZMAs. Consequently, the HEE allows the Zn||Zn symmetric cell to cycle over 1650 h at 2 mA cm−2 and 1 mA h cm−2. Moreover, the Zn||NH4V4O10 full batteries can deliver a prolonged lifespan for 1000 cycles with a high capacity retention of 83.4%. This work represents a feasible approach toward the elaborate design of advanced electrolyte systems for next‐generation batteries.
A Versatile Approach to Stabilize Liquid–Liquid Interfaces using Surfactant Self‐Assembly
Authors: Honaryar Houman , Amirfattahi Saba , Nguyen Duoc , Kim Kyungtae , Shillcock Julian C. , Niroobakhsh Zahra 
Published: June 2024

AbstractStabilizing liquid–liquid interfaces, whether between miscible or immiscible liquids, is crucial for a wide range of applications, including energy storage, microreactors, and biomimetic structures. In this study, a versatile approach for stabilizing the water‐oil interface is presented using the morphological transitions that occur during the self‐assembly of anionic, cationic, and nonionic surfactants mixed with fatty acid oils. The morphological transitions underlying this approach are characterized and extensively studied through small‐angle X‐ray scattering (SAXS), rheometry, and microscopy techniques. Dissipative particle dynamics (DPD) as a simulation tool is adopted to investigate these morphological transitions both in the equilibrium ternary system as well as in the dynamic condition of the water‐oil interface. Such a versatile strategy holds promise for enhancing applications such as liquid‐in‐liquid 3D printing. Moreover, it has the potential to revolutionize a wide range of fields where stabilizing liquid–liquid interfaces not only offers unprecedented opportunities for fine‐tuning nanostructural morphologies but also imparts interesting practical features to the resulting liquid shapes. These features include perfusion capabilities, self‐healing, and porosity, which could have significant implications for various industries.
Trinitarian Design of Gradient Artificial Interphase Enables Colossal Granular Li Deposits for Stable Li‐Metal Batteries
Authors: Wang Kun , Wang Xiangxiang , Gao Jianhong , Zheng Zefan , Ye Jialin , Ahmad Waqar , Zhou Chuhan , Li Han , Li Siying , Ma Yongqun , Ling Min , Zhang Haibing , Gao Xuehui , Liang Chengdu 
Published: June 2024

AbstractThe cycling lifespan of Li‐metal batteries is compromised by the unstable solid electrolyte interphase (SEI) and the continuous Li dendrites, restricting their practical implementations. Given these challenges, establishing an artificial SEI holds promise. Herein, a trinitarian gradient interphase is innovatively designed through composite coatings of magnesium fluoride (MgF2), N‐hexadecyltrimethylammonium chloride (CTAC), and polyvinylidene fluoride‐hexafluoropropylene copolymer (PVDF‐HFP) on Li‐metal anode (LMA). Specifically, the MgF2/CTAC/PVDF‐HFP SEI spontaneously forms a lithium fluoride (LiF)‐rich PVDF‐HFP‐based SEI, along with lithium‐magnesium (Li‐Mg) alloy substrate as lithiophilic electronic conductor and positively charged CTAC during plating. Noticeably, the Li‐Mg alloy homogenizes the distribution of electric field and reduce the internal resistance, while the electronically insulated LiF/PVDF‐HFP composite SEI offers fast ion‐conducting and mechanical flexibility, accommodating the volumetric expansion and ensuring stable Li‐ion flux. Additionally, CTAC at the dendritic tip is pivotal for mitigating dendrites through its electrostatic shield mechanism. Innovatively, this trinitarian synergistic mechanism, which facilitates colossal granular Li deposits, constructs a dendrite‐free LMA, leading to stable cycling performances in practical Li||LFP, popular Li||NCM811, and promising Li||S full cells. This work demonstrates the design of multifunctional composite SEI for comprehensive Li protection, thereby inspiring further advancements in artificial SEI engineering for alkali‐metal batteries.