bluuebunny/crossref_metadata_2025_split huggingface dataset:
Chronic Granulomatous Tenosynovitis Treated With Ulnar Superficialis Slip Resection
Authors: Rubin Guy , Wolovelsky Alejandro , Rinott Micha , Rozen Nimrod 
Published: April 2010

Ulnar superficialis slip resection is a procedure initially performed to treat flexor tenosynovitis in the rheumatoid finger. It was first described for treating trigger digits of children with mucopolysaccharide storage disorders and for more complex trigger digits in children. The procedure for adults with trigger finger was described for triggering with flexion contracture at the proximal interphalangeal joint level persisting after release of the A1 pulley and for trigger finger in diabetic patients.
This article describes a case of chronic flexor tenosynovitis treated with ulnar superficialis slip resection. The patient was injured by the needle of a water pressure gauge. He developed chronic flexor tenosynovitis, and 1 year after the initial injury, surgery was performed due to a severe limitation of passive and active proximal interphalangeal joint flexion. Synovectomy was performed first, then the A1 pulley was divided. Passive finger flexion and extension was simulated and failed to reproduce full range of motion (ROM). The A3 pulley was then divided and still failed to reproduce full ROM. The ulnar slip of the flexor digitorum superficialis tendon was then resected from the distal margin of the carpal tunnel to the distal edge of the A3 pulley. The tendons could now move smoothly, and full passive ROM was achieved.
Surgery consisting of synovectomy alone with or without resection of the A1 pulley without achieving full intraoperative ROM will likely lead to a poor result. We believe that cases like ours should be addressed with an “à la carte” procedure, starting with synovectomy and followed by A1 resection, A3 resection, and finally ulnar superficialis slip resection for achieving full intraoperative ROM.
Simultaneous Acute Rotator Cuff Tear and Distal Biceps Rupture in a Strongman Competitor
Authors: George Michael S. 
Published: April 2010

Acute rotator cuff tear is commonly associated with tearing of the proximal biceps tendon, but has never been reported to occur simultaneously with a distal biceps tendon rupture. A 38-year-old right-hand-dominant strongman competitor attempted a 300-pound overhead axle press and experienced immediate pain in the right shoulder and elbow. He had no known systemic risk factors for tendon ruptures including hyperparathyroidism, hemodialysis, alcoholism, rheumatoid arthritis, statin medications, fluoroquinolones, and steroid use.
Right shoulder magnetic resonance imaging (MRI) showed a full-thickness supraspinatus tear with 3 cm of retraction. There was minimal fatty infiltration of the supraspinatus on the sagittal cuts consistent with acute rupture. The subscapularis was intact. The long head of the biceps tendon had mild medial subluxation but was completely within the bicipital groove. Right elbow MRI showed a complete distal biceps tendon rupture. Thirteen days after his injury, the patient underwent arthroscopic supraspinatus repair and proximal biceps tenodesis. Distal biceps tendon repair was performed using the modified 2-incision muscle-splitting technique. At 24-month follow-up, the patient was pain free and had returned to full activity including weightlifting but had not returned to strongman competition.
This is the first report of simultaneous acute full thickness ruptures of the rotator cuff and distal biceps tendon. This case report underscores the importance of a complete physical examination and a high index of suspicion for additional concomitant injuries, particularly in athletes with unusually high stresses to the body.
Epithelial, Stromal, and Total Corneal Thickness in Keratoconus: Three-dimensional Display With Artemis Very-high Frequency Digital Ultrasound
Authors: Reinstein Dan Z. , Gobbe Marine , Archer Timothy J. , Silverman Ronald H. , Coleman D. Jackson 
Published: April 2010

PURPOSE:
To characterize the epithelial, stromal, and total corneal thickness profile in a population of eyes with keratoconus.

METHODS:
Epithelial, stromal, and total corneal thickness profiles were measured in vivo by Artemis very high-frequency (VHF) digital ultrasound scanning (ArcScan) across the central 6- to 10-mm diameter of the cornea on 54 keratoconic eyes. Maps of the average, standard deviation, minimum, maximum, and range of epithelial, stromal, and total corneal thickness were plotted. The average location of the thinnest epithelium, stroma, and total cornea were found. The cross-sectional semi-meridional stromal and total corneal thickness profiles were calculated using annular averaging. The absolute stromal and total corneal thickness progressions relative to the thinnest point were calculated using annular averaging as well as for 8 semi-meridians individually.

RESULTS:
The mean corneal vertex epithelial, stromal, and total corneal thicknesses were 45.7±5.9 µm, 426.4±38.5 µm, and 472.2±41.4 µm, respectively. The average epithelial thickness profile showed an epithelial doughnut pattern characterized by localized central thinning surrounded by an annulus of thick epithelium. The thinnest epithelium, stroma, and total cornea were displaced on average by 0.48±0.66 mm temporally and 0.32±0.67 mm inferiorly, 0.31±0.45 mm temporally and 0.54±0.37 mm inferiorly, and 0.31±0.43 mm temporally and 0.50±0.35 mm inferiorly, respectively, with reference to the corneal vertex. The increase in semi-meridional absolute stromal and total corneal thickness progressions was greatest inferiorly and lowest temporally.

CONCLUSIONS:

Three-dimensional thickness mapping of the epithelial, stromal, and total corneal thickness profiles characterized thickness changes associated with keratoconus and may help in early diagnosis of keratoconus. [
J Refract Surg
. 2010;26:259–271.]
Changes in Ocular Response Analyzer Parameters After LASIK
Authors: Chen Shihao , Chen Ding , Wang Jianhua , Lu Fan , Wang Qinmei , Qu Jia 
Published: April 2010

PURPOSE:
To investigate changes in Ocular Response Analyzer parameters after myopic LASIK.

METHODS:
Thirty myopic patients (60 eyes) undergoing bilateral LASIK were studied prospectively. Corneal hysteresis, corneal resistance factor, Goldmann-correlated intraocular pressure (IOPg), and corneal-compensated IOP (IOPcc) measurements were obtained with the Ocular Response Analyzer before and after LASIK. Central corneal thickness and corneal flap thickness were also measured with optical coherence tomography.

RESULTS:

Compared with preoperative baseline values, corneal hysteresis, corneal resistance factor, IOPg, IOPcc, and central corneal thickness decreased postoperatively (
P
<.01). Corneal hysteresis (CH), corneal resistance factor (CRF), IOPg, IOPcc, and central corneal thickness (CCT) increased between 10 days and 3 months (post-hoc,
P
<.05). (The differences between the preoperative values and those at 3 months postoperatively are denoted by Δ.) The correlation of the ablation depth was stronger for ΔCRF (r=0.457) than for ΔCH (r=0.271). ΔCH was negatively correlated to flap thickness (r=−0.361) and the ratio of flap thickness to preoperative central corneal thickness (r=−0.442) whereas ΔCRF was not. ΔCH was positively correlated with ΔIOPcc, and ΔCRF was positively correlated with ΔIOPg. ΔIOPg was positively correlated with ΔCCT whereas ΔIOPcc was not.

CONCLUSIONS:

Corneal biomechanical properties measured by corneal hysteresis and corneal resistance factor were decreased at 10 days after LASIK. Minimal recovery (approximately 10% of the changes) was achieved by 3 months. The changes in biomechanical properties may affect IOP measurement. [
J Refract Surg
. 2010;26:279–288.]
LASIK Correction of Vision in Adults with Unilateral Amblyopia
Authors: Oruçoğlu - Orucov Faik , Frucht-Pery Joseph , Landau David , Strasman Eyal , Solomon Abraham 
Published: April 2010

Purpose:
To evaluate the effects of laser refractive surgery in adult patients with mild to moderate amblyopia due to anisometropic myopia.

Methods:
A retrospective review of 30 patients (60 eyes) with unilateral amblyopia (corrected distance visual acuity [CDVA] 0.6 or worse) who underwent simultaneous bilateral laser vision correction using the Technolas 217z excimer laser (Bausch & Lomb) was performed. Mean patient age was 31.03±10.05 years (range: 18 to 53 years). Visual outcomes in the amblyopic eye were compared with those in the fellow nonamblyopic control eye of the same patient.

Results:

Mean preoperative CDVA improved in amblyopic eyes from 0.50±0.13 to 0.57±0.20 postoperatively (average gain of 0.075±0.14;
P
=.007) and improved from 0.92±0.12 preoperatively to 0.93±0.15 after surgery (mean gain of 0.013±0.14;
P
=.603) in the fellow nonamblyopic eyes. The safety index was significantly greater in the amblyopic eyes compared with the nonamblyopic fellow eyes (1.15±0.30 vs 1.02±0.15,
P
=.035), therefore, no difference was noted in efficacy (
P
=.913). Five of 30 eyes with mild to moderate amblyopia gained 2 to 4 lines of CDVA.

Conclusions:
Laser refractive surgery for myopic correction was found to be safe and effective in eyes with mild to moderate amblyopia.
Live or Let Die: Epithelial Flap Vitality and Keratocyte Proliferation Following LASEK and Epi-LASIK in Human Donor and Porcine Eyes
Authors: Angunawela Romesh I. , Winkler von Mohrenfels Christoph , Kumar Anupma , O’Brart David P.S. , Marshall John 
Published: April 2010

Purpose:
To determine the relationship between epithelial flap vitality and stromal keratocyte proliferation following two epithelial refractive techniques: epi-LASIK and laser epithelial keratomileusis (LASEK).

Methods:
Human corneas were maintained in organ culture and underwent standard −6.00-diopter ablation. Rates of stromal keratocyte proliferation were detected 1 week postoperative using a Ki67 antibody specific to proliferating cells. Images were captured with a laser scanning confocal microscope and analyzed by a masked observer. Epithelial flap vitality was determined with propidium iodide using fresh porcine corneas. Epithelial flaps were created with Gebauer Epikeratome epi-LASIK or alcohol-assisted LASEK method. Flaps treated with 100% alcohol and uninjured corneas were used as controls.

Results:

The number of proliferating keratocytes was greatest at 1 week in the epi-LASIK corneas (
P
<.001). Cell vitality was greatest in the epi-LASIK flaps and declined in the LASEK and 100% alcohol flaps (
P
<.001).

Conclusions:
In this in vitro setting, epi-LASIK results in an epithelial flap with significantly more live cells. There is also a greater number of proliferating stromal cells following epi-LASIK at 1 week. Based on these in vitro observations, epi-LASIK may result in greater levels of haze compared to LASEK.
Repeatability of Retinal Thickness Measurements Between Spectral-Domain and Time-Domain Optical Coherence Tomography Images in Macular Disease
Authors: Domalpally Amitha , Gangaputra Sapna , Peng Qian , Danis Ronald P. 
Published: April 2010

Background and Objective:
To evaluate and compare the intra-session repeatability of retinal thickness measurements from the Topcon 3D OCT 1000 (Topcon Medical Systems; Paramus, NJ), a spectral-domain optical coherence tomography (SD-OCT) system, with the Stratus (Carl Zeiss Meditec, Inc., Dublin, CA), a time-domain OCT (TD-OCT) system, in eyes with retinal diseases.

Patients and Methods:
Repeated scans with both SD-OCT and TD-OCT were taken. Thickness measurements from high-quality scans were used to assess repeatability and compare measurements between the two instruments.

Results:

Paired scans from 127 eyes were evaluated, of which 63 pairs were of high quality. Coefficients of repeatability and variation for the central subfield were 20.1 μm (2.6%) with SD-OCT and 27.4 μm (4%) with TD-OCT (
P
= .38). The mean difference in central subfield thickness between the two instruments was 24.5 μm (standard deviation = 20.9).

Conclusion:
Repeatability of retinal thickness measurements with the Topcon 3D OCT 1000 is comparable to the Stratus. The measurements of the two machines differ significantly and cannot be used interchangeably.
A New Vascular Pattern for Idiopathic Juxtafoveal Telangiectasia Revealed by the Retinal Function Imager
Authors: Landa Gennady , Rosen Richard B. 
Published: April 2010

Background and Objective:
The Retinal Function Imager (RFI) (Optical Imaging, Rehovot, Israel) is a novel method for assessing retinal blood flow characteristics and demonstrating the dynamics of fine retinal vasculature. The authors report a new pattern of retinal blood flow in five patients with idiopathic juxtafoveal telangiectasia (IJT) type 2.

Patients and Methods:
Retinal circulation is imaged using the RFI as a series of high-speed stroboscopically captured fundus photographs. Proprietary software aligns the images, allowing serial subtraction, and creates short video loops that show movement of red blood cells in the small and medium size retinal blood vessels.

Results:
Ten eyes of five patients with IJT type 2 were examined. In all cases, the RFI demonstrated a common pattern of centripetal vascular flow in the region of telangiectasia. This pattern is unique in its configuration of vascular flow into the focus of the area of telangiectasia. This pattern could not be appreciated on fluorescein angiography.

Conclusion:
The RFI can detect the specific vascular pattern of the retinal blood flow in eyes of patients with IJT. The ability to characterize such blood flow patterns may aid in identification of ambiguous cases of IJT when the diagnosis is not straightforward.
Wetting Behavior of Amorphous and Crystalline Silicon Dioxide in Contact with a Silicate Slag Based on Fayalite
Authors: Aneziris Christos G. , Dudczig Steffen 
Published: April 2010

AbstractIn this work the wetting behaviour of amorphous and crystalline silicon dioxide in contact with a silicate slag based on fayalite is demonstrated as a function of contact angles, activation energies of the kinetic stages of wetting. In addition the dynamic adhesion work has been calculated as a function of the inclination angle. The amorphous silicon dioxide in contact with the slag presents lower contact angles accompanied also by higher dynamic adhesion works in comparison to crystalline porous ceramics with the same chemistry.
Microstructural and Mechanical Investigations on Porcelain‐Fused‐to‐Metal in Multilayer System
Authors: Carradò Adele , Palkowski Heinz 
Published: April 2010

AbstractResults on porcelain‐fused‐to‐metal (PFM) technique of ceramic films for biomedical applications on metal substrate are reported. The coating of metallic implants with bio‐ceramic films (glassy and opaque ceramic) was proposed to be a solution for combining the mechanical properties of the metallic material with the bioactive character of the ceramic layer, leading to a better integration of the entire implant. The aim of this paper is to determine a stress field distribution by a non‐destructive method as high‐energy synchrotron X‐ray diffraction in energy dispersive in the metal and glass ceramic bulk as well as at metal–opaque ceramic interface in PFM three layers sample. Tensile stresses were found in palladium substrate and compressive state in glass ceramic coating. Moreover thermal stresses induced by PFM coating at the interfaces were calculated by analytical mathematical model, confirming that the stresses induced, due to the selection of the materials, are low. Finally, the micro‐structural and chemical characteristics of glassy and opaque bio‐ceramic coatings on palladium alloy substrate were investigated and no inter‐diffusion area between metal and ceramic could be detected as well as non‐homogeneity in the interface ceramic.
Annealing of Biodegradable Polymer Induced by Femtosecond Laser Micromachining
Authors: Yeong Wai Yee , Lim Kee Pah , Ng Gary Ka Lai , Tan Lay Poh , Boey Freddy Yin Chiang , Venkatraman Subbu S. 
Published: April 2010

AbstractFemtosecond laser is a potential tool for net shape processing of biodegradable polymers. However, laser processing of polymeric material is still a challenge and the effects induced by laser ablation needs to be investigated. Poly(ε‐caprolactone) was micromachined at high fluence and the heat affected zone was characterized. Two different phases of microstructure, namely the annealed spherulite zone and the amorphous zone, are found.
In Vitro Characteristics of Surface‐Modified Biphasic Calcium Phosphate/Poly(L‐Lactide) Biocomposite
Authors: Yang Weizhong , Yin Guangfu , Zhou Dali , Gu Jianwen , Li Yadong 
Published: April 2010

AbstractSurface‐modified biphasic calcium phosphate (BCP)/poly(L‐lactide) (PLLA) biocomposite is shown to have improved microstructure and mechanical properties compared to the unmodified system. In vitro biodegradation and bioactivity of the composite are investigated in simulate body fluid for up to four weeks. Weight changes of the samples and the pH changes of the SBF are recorded. Surface properties of the composite after immersion are characterized by XRD, SEM and EDX analyses. Cyto‐compatibility was determined by MTT assay with L929 mouse fibroblasts. The difference of the degradation behavior between modified BCP/PLLA and the reference unmodified composite are investigated, and mBCP/PLLA composite is proved to be a better as a scaffold material. The surface formed bio‐apatite layer after immersion shows the excellent bioactivity of the mBCP/PLLA composite. L929 cells show a high growth rate and proliferation, demonstrating the good cytocompatibility of mBCP/PLLA composite.
In‐Film Bioprocessing and Immunoanalysis with Electroaddressable Stimuli‐Responsive Polysaccharides
Authors: Yang Xiaohua , Kim Eunkyoung , Liu Yi , Shi Xiao‐Wen , Rubloff Gary W. , Ghodssi Reza , Bentley William E. , Pancer Zeev , Payne Gregory F. 
Published: April 2010

AbstractAdvances in thin‐film fabrication are integral to enhancing the power of microelectronics while fabrication methods that allow the integration of biological molecules are enabling advances in bioelectronics. A thin‐film‐fabrication method that further extends the integration of biology with microelectronics by allowing living biological systems to be assembled, cultured, and analyzed on‐chip with the aid of localized electrical signals is described. Specifically, the blending of two stimuli‐responsive film‐forming polysaccharides for electroaddressing is reported. The first, alginate, can electrodeposit by undergoing a localized sol–gel transition in response to electrode‐imposed anodic signals. The second, agarose, can be co‐deposited with alginate and forms a gel upon a temperature reduction. Electrodeposition of this dual polysaccharide network is observed to be a simple, rapid, and spatially selective means for assembly. The bioprocessing capabilities are examined by co‐depositing a yeast clone engineered to display a variable lymphocyte receptor protein on the cell surface. Results demonstrate the in‐film expansion and induction of this cell population. Analysis of the cells' surface proteins is achieved by the electrophoretic delivery of immunoreagents into the film. These results demonstrate a simple and benign means to electroaddress hydrogel films for in‐film bioprocessing and immunoanalysis.
Animal models of Williams syndrome
Authors: Osborne Lucy R. 
Published: April 2010

AbstractIn recent years, researchers have generated a variety of mouse models in an attempt to dissect the contribution of individual genes to the complex phenotype associated with Williams syndrome (WS). The mouse genome is easily manipulated to produce animals that are copies of humans with genetic conditions, be it with null mutations, hypomorphic mutations, point mutations, or even large deletions encompassing many genes. The existing mouse models certainly seem to implicate hemizygosity for ELN, BAZ1B, CLIP2, and GTF2IRD1 in WS, and new mice with large deletions of the WS region are helping us to understand both the additive and potential combinatorial effects of hemizygosity for specific genes. However, not all genes that are haploinsufficient in humans prove to be so in mice and the effect of genetic background can also have a significant effect on the penetrance of many phenotypes. Thus although mouse models are powerful tools, the information garnered from their study must be carefully interpreted. Nevertheless, mouse models look set to provide a wealth of information about the neuroanatomy, neurophysiology and molecular pathways that underlie WS and in the future will act as essential tools for the development and testing of therapeutics. © 2010 Wiley‐Liss, Inc.
Inversion of the Williams syndrome region is a common polymorphism found more frequently in parents of children with Williams syndrome
Authors: Hobart Holly H. , Morris Colleen A. , Mervis Carolyn B. , Pani Ariel M. , Kistler Doris J. , Rios Cecilia M. , Kimberley Kendra W. , Gregg Ronald G. , Bray‐Ward Patricia 
Published: April 2010

AbstractWilliams syndrome (WS) is a multisystem disorder caused by deletion of about 1.55 Mb of DNA (including 26 genes) on chromosome 7q11.23, a region predisposed to recombination due to its genomic structure. Deletion of the Williams syndrome chromosome region (WSCR) occurs sporadically. To better define chance for familial recurrence and to investigate the prevalence of genomic rearrangements of the region, 257 children with WS and their parents were studied. We determined deletion size in probands by metaphase FISH, parent‐of‐origin of the deleted chromosome by molecular genetic methods, and inversion status of the WSCR in both parents by interphase FISH. The frequency of WSCR inversion in the transmitting parent group was 24.9%. In contrast, the rate of inversion in the non‐transmitting parent group (a reasonable estimate of the rate in the general population) was 5.8%. There were no significant gender differences with respect to parent‐of‐origin for the deleted chromosome or the incidence of the inversion polymorphism. There was no difference in the rate of spontaneous abortion for mothers heterozygous for the WSCR inversion relative to mothers without the inversion. We calculate that for a parent heterozygous for a WSCR inversion, the chance to have a child with WS is about 1 in 1,750, in contrast to the 1 in 9,500 chance for a parent without an inversion. © 2010 Wiley‐Liss, Inc.
Sensory modulation impairments in children with Williams syndrome
Authors: John Angela E. , Mervis Carolyn B. 
Published: April 2010

AbstractThe ability to organize information detected by our senses (“sensory modulation”) allows us to act or respond effectively to situations encountered, facilitating learning, social behavior, and day‐to‐day functioning. We hypothesized that children with Williams syndrome (WS) would demonstrate symptoms of poor sensory modulation and that these sensory modulation abnormalities contribute to the phenotype. Participants were 78 children with WS aged 4.00–10.95 years. Based on parent ratings on the Short Sensory Profile [SSP; Dunn,1999], most children were classified as having definite sensory modulation issues. Cluster analysis identified the presence of two clusters varying in level of sensory modulation impairment. Children in thehigh impairment groupdemonstrated poorer adaptive functioning, executive functioning, more problem behaviors, and more difficult temperaments than children in thelow impairment group. © 2010 Wiley‐Liss, Inc.