bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinicopathological and prognostic implications of EGFR mutations subtypes in Moroccan non-small cell lung cancer patients: A first report
Authors: Boukansa Sara , Mouhrach Ismail , El Agy Fatima , El Bardai Sanae , Bouguenouch Laila , Serraj Mounia , Amara Bouchra , Ouadnouni Yassine , Smahi Mohamed , Alami Badreeddine , Mellas Nawfel , Benbrahim Zineb , El Fatemi Hinde 
Published: June 2024

Background
Non-small cell lung cancer (NSCLC) remains a significant global health concern, with EGFR mutations playing a pivotal role in guiding treatment decisions. This prospective study investigated the prevalence and clinical implications of EGFR mutations in Moroccan NSCLC patients.

Methods
A cohort of 302 NSCLC patients was analyzed for EGFR mutations using multiple techniques. Demographic, clinical, and pathological characteristics were assessed, and overall survival (OS) outcomes were compared among different EGFR mutation subtypes.

Results
EGFR mutations were present in 23.5% of patients, with common mutations (81.69%) dominating. Common mutations showed strong associations with female gender and non-smoking status, while rare mutations were associated with a positive smoking history. Patients with EGFR mutations receiving tyrosine kinase inhibitors (TKIs) had significantly improved OS compared to wild-type EGFR patients. Notably, patients with common EGFR mutations had the highest OS, while those with rare mutations had a shorter survival period, albeit not statistically significant.

Conclusion
This study highlights the relevance of EGFR mutation status in NSCLC patients, particularly in therapeutic decision-making. The association between smoking history and rare mutations suggests the need for tailored approaches. The survival advantage for patients with common EGFR mutations underscores the significance of personalized treatment strategies.
The impact of perinatal maternal stress on the maternal and infant gut and human milk microbiomes: A scoping review protocol
Authors: Ryan Niamh , Leahy-Warren Patricia , Mulcahy Helen , O’Mahony Siobhain , Philpott Lloyd 
Published: June 2024

Objective
The objective of this scoping review is to review the research evidence regarding the impact of perinatal maternal stress on the maternal and infant gut and human milk microbiomes.

Introduction
Perinatal stress which refers to psychological stress experienced by individuals during pregnancy and the postpartum period is emerging as a public health concern. Early exposure of infants to perinatal maternal stress can potentially lead to metabolic, immune, and neurobehavioral disorders that extend into adulthood. The role of the gut and human milk microbiome in the microbiome-gut-brain axis as a mechanism of stress transfer has been previously reported. A transfer of colonised aberrant microbiota from mother to infant is proposed to predispose the infant to a pro- inflammatory microbiome with dysregulated metabolic process thereby initiating early risk of chronic diseases. The interplay of perinatal maternal stress and its relationship to the maternal and infant gut and human milk microbiome requires further systematic examination in the literature.

Inclusion criteria
This scoping review is an exploratory mapping review which will focus on the population of mothers and infants with the exploration of the key concepts of maternal stress and its impact on the maternal and infant gut and human milk microbiome in the context of the perinatal period. It will focus on the pregnancy and the post-natal period up to 6 months with infants who are exclusively breastfed.

Methods
This study will be guided by the Joanna Briggs Institute’s (JBI) methodology for scoping reviews along with use of the Prisma Scr reporting guideline. A comprehensive search will be conducted using the following databases, CINAHL Complete; MEDLINE; PsycINFO, Web of Science and Scopus. A search strategy with pre-defined inclusion and exclusion criteria will be used to retrieve peer reviewed data published in English from 2014 to present. Screening will involve a three-step process with screening tool checklists. Results will be presented in tabular and narrative summaries, covering thematic concepts and their relationships. This protocol is registered with Open Science Framework DOI 10.17605/OSF.IO/5SRMV.
Die Weiterentwicklung der Sozialen Marktwirtschaft angesichts planetarer Belastungsgrenzen
Authors: Lange Sarah , Goldschmidt Nils 
Published: June 2024

Die planetaren Belastungsgrenzen stellen auch das deutsche Wirtschafts- und Sozialsystem vor substanzielle Herausforderungen. In diesem­ Beitrag wird aufgezeigt, dass die Soziale Marktwirtschaft konzeptionell und praktisch das Potenzial hat, die ökologisch gebotenen Reformen umzusetzen und im Sinne individueller Lebenschancen zu gestalten.
Well‐controlled mucosal exudation of plasma proteins in airways with intact and regenerating epithelium
Authors: Persson Carl 
Published: June 2024

AbstractSuperficial, systemic microcirculations, distinct from the pulmonary circulation, supply the mucosae of human nasal and conducting airways. Non‐injurious, inflammatory challenges of the airway mucosa cause extravasation without overt mucosal oedema. Instead, likely reflecting minimal increases in basolateral hydrostatic pressure, circulating proteins/peptides of all sizes are transmitted paracellularly across the juxtaposed epithelial barrier. Thus, small volumes of extravasated, unfiltered bulk plasma appear on the mucosal surface at nasal and bronchial sites of challenge. Importantly, the plasma‐exuding mucosa maintains barrier integrity against penetrability of inhaled molecules. Thus, one‐way epithelial penetrability, strict localization, and well‐controlled magnitude and duration are basic characteristics of the plasma exudation response in human intact airways. In vivo experiments in human‐like airways demonstrate that local plasma exudation is also induced by non‐sanguineous removal of epithelium over an intact basement membrane. This humoral response results in a protective, repair‐promoting barrier kept together by a fibrin‐fibronectin net. Plasma exudation stops once the provisional barrier is substituted by a new cellular cover consisting of speedily migrating repair cells, which may emanate from all types of epithelial cells bordering the denuded patch. Exuded plasma on the surface of human airways reflects physiological microvascular‐epithelial cooperation in first line mucosal defense at sites of intact and regenerating epithelium.
Household Size and Access to Education in Rural Burundi: The Case of Mutaho Commune
Authors: Ndayishimiye Bosco , Manirakiza René , Kakuba Christian , Sindayihebura Jean François Régis , Barankanira Emmanuel 
Published: June 2024

Abstract
While education is recognized as a fundamental human right and an important factor in improving economic and social conditions, child schooling rates in Burundi show that there are still children of school-age who are not attending school and those who drop out very prematurely. This scientific study aims to highlight the relationship between household size and access to education in Mutaho commune (rural Burundi) by documenting the socio-demographic factors of the head of household likely to influence the schooling status of children aged 7–17. The hypothesis put forward in this study is that children’s schooling is influenced by household size. Data from a survey of 215 households in the Mutaho commune were analyzed using binomial logistic regression. The analysis shows that a large household size (OR = 5.463; p < 0.05; 95% CI: 1.311–22.771) is negatively associated with the education of children aged 7–17 living in Mutaho commune. Reducing fertility should be an integral concern for all those involved in the fields of population, education, and development.
Improved tag estimation method for TDMA anticollision protocols using CA-CFAR technique
Authors: Frahtia Abderrahmene , Benssalah Mustapha , Kifouche Abdenour , Drouiche Karim 
Published: June 2024

Abstract
Radio Frequency Identification (RFID) is considered a key element of the Internet of Things (IoT). It enables objects to be identified and tracked using radio waves. In RFID systems, several tags may be present within the range of the reader, leading to collisions and interference between signals that reduce system performance. Several anti-collision solutions have been proposed to solve this problem based on TDMA (Time-Division Multiple Access) technique, such as the ALOHA, Slotted ALOHA and Dynamic Framed Slotted ALOHA (DFSA) protocols. In this paper, we propose to improve TDMA anti-collision protocols based on the Cell Averaging Constant False Alarm Rate (CA-CFAR) scheme. The CA-CFAR technique is introduced to estimate the number of tags in the physical layer so that the reader can adjust its transmission parameters accordingly and avoid collisions. The obtained results show that this technique achieves good results in terms of system efficiency and the number of required slots to identify all the tags of the system.
Sodium titanium oxide/zinc oxide (STO/ZnO) photocomposites for efficient dye degradation applications
Authors: Zayed Mohamed , Nasr Mervat , Aljaafreh Mamduh J. , Marashdeh Mohammad , Al-Hmoud M. , Shaban Mohamed , Rabia Mohamed , Tarek Amna , Ahmed Ashour M. 
Published: June 2024

Abstract
In this study, sodium titanium oxide (Na2Ti3O7, termed STO) and sodium titanate/zinc oxide (STO/ZnO) photocomposites were prepared for the first time. A low-cost hydrothermal technique was employed to fabricate the STO/ZnO photocomposites with varying ZnO weight ratios: STO/0.25ZnO, STO/0.5ZnO, and STO/ZnO. The prepared photocomposites were investigated for the decomposition of methylene blue dye (MB) under natural visible light illumination and an artificial tungsten halogen lamp. The STO/ZnO photocomposite exhibits high photodegradation performance, which can be correlated with its properties and characterization. The X-ray diffraction analysis reveals that STO has an average crystallite size of 69.1 nm, ZnO has an average crystallite size of 41.4 nm, and the combination of STO/ZnO results in a reduced average crystallite size of 39.5 nm. The bandgap (E
g) of STO/ZnO is 2.53 eV after controlling the ZnO weight ratio. The photocatalytic efficiency of the STO/ZnO photocomposite was 100% for MB within 60 min of solar light irradiation, compared to 33.7% for STO and 25.8% for ZnO. The effect of STO/ZnO dosage and MB concentration was investigated. Furthermore, the kinetics and mechanisms of the photocatalytic process were examined. The results suggest that STO/ZnO has promising potential for practical applications in wastewater treatment.
Enhancing mechanical and rheological properties of HDPE films through annealing for eco-friendly agricultural applications
Authors: Yang Ning , Li Ying , Feng Liangshan , Liu Qi , Luo Qing , Liu Jialei 
Published: June 2024

Abstract
A composite of high-density polyethylene/ultra-high molecular weight polyethylene (HDPE/UHMWPE) was synthesized via a high-temperature melting process. We specifically examined the effects of annealing on the morphological and rheological properties of the composite. Using scanning electron microscopy and advanced rotational rheometry, we determined that annealing notably alters the composite’s microstructure, with a reduction in pronounced features post-treatment. Rheologically, UHMWPE content significantly enhanced mechanical properties, particularly in storage modulus (G′), loss modulus (G″), and complex viscosity (|η*|), which aligned with scaling law principles. Our findings highlight a distinct improvement in mechanical properties post-annealing, underscoring the potential of UHMWPE in enhancing polymer composite performance. The scaling laws relating G′, G″, and |η*| with UHMWPE were identified as follows: (1) pre-c
e: G′ ∼ c
0.2, g″ ∼ c
0.07, |η*| ～ c0.07 and (2) post-c
e: G′ ∼ c
1.20, g″ ∼ c
0.6, |η*| ∼ c
0.64, with a forward shift in c
e noted after annealing. The addition of UHMWPE significantly enhanced the system’s properties, particularly after annealing. This study offers crucial insights into optimizing HDPE plastic films for enhanced durability and sustainability, ideally suiting them for eco-friendly agricultural uses.
The power of memes: personification as a marker of psychological distance in memes about the war in Ukraine
Authors: Laineste Liisi , Fiadotava Anastasiya , Troitskiy Sergey , Castañar Guillem 
Published: June 2024

AbstractMemes offer responsive acute commentary on controversial societal matters, providing non-violent and democratic spaces of discussion for conflicts. The paper studies memes on the war in Ukraine that spread in Eastern (Russia, Estonia, Belarus) and Western Europe (Spain). We analyze who are the main actors/characters that personify the war in the memes in these countries, how these characters are represented in memes, and what are the global and local aspects of their portrayal. Personification is seen as a marker for psychological distance of the meme-makers and sharers to the conflict.
Systematic literature review on intrusion detection systems: Research trends, algorithms, methods, datasets, and limitations
Authors: Issa Melad Mohammed , Aljanabi Mohammad , Muhialdeen Hassan M. 
Published: June 2024

AbstractMachine learning (ML) and deep learning (DL) techniques have demonstrated significant potential in the development of effective intrusion detection systems. This study presents a systematic review of the utilization of ML, DL, optimization algorithms, and datasets in intrusion detection research from 2018 to 2023. We devised a comprehensive search strategy to identify relevant studies from scientific databases. After screening 393 papers meeting the inclusion criteria, we extracted and analyzed key information using bibliometric analysis techniques. The findings reveal increasing publication trends in this research domain and identify frequently used algorithms, with convolutional neural networks, support vector machines, decision trees, and genetic algorithms emerging as the top methods. The review also discusses the challenges and limitations of current techniques, providing a structured synthesis of the state-of-the-art to guide future intrusion detection research.
Green synthesis of copper oxide nanoparticles using genus Inula and evaluation of biological therapeutics and environmental applications
Authors: Alangari Abdulaziz , Aboul-Soud Mourad A. M. , Alqahtani Mohammed S. , Shahid Mudassar , Syed Rabbani , Lakshmipathy R. , Modigunta Jeevan Kumar Reddy , Jaiswal Harshita , Verma Meenakshi 
Published: June 2024

Abstract
In this research, we produced copper oxide nanoparticles (CuO NPs) using extracts from the entire above-ground portion of plants of genus Inula (Inula graveolens). The synthesis of CuO NPs was verified through various physicochemical analytical methods, including UV–visible, Fourier transform infrared, and transmission electron microscopy. The CuO NPs were found to be around 20 nm in size and spherical in shape. Subsequently, the synthesized compounds were evaluated for their anticancer properties. After treating A549 cells with CuO NPs at concentrations of 15 and 30 μg, we examined their cytotoxicity, lipid peroxidation activity (malondialdehyde level), and antioxidant activity (catalase, superoxide dismutase, and glutathione levels). Additionally, we analyzed the expression of apoptotic marker genes (p53, caspase-3, and caspase-9), cytokine levels (IL-6 and TNF-α), and DNA fragmentation. Our findings demonstrated that CuO NPs enhanced the expression of apoptotic genes, suggesting that phytochemical-derived NPs from Inula extracts induce apoptosis by upregulating tumor suppressor genes and downregulating oncogenes in A549 cells. Furthermore, CuO NPs exhibited higher susceptibility toward B. subtilis and S. aureus compared to ampicillin. Using the response surface methodology, we determined that CuO NPs are effective adsorbents for removing Pb2+ ions from aqueous solutions, making them promising for environmental applications. Overall, our results indicate that CuO NPs have potential as antimicrobial, antioxidant, and anticancer agents and as efficient adsorbents.
Sustainability analysis and decision-making strategy for swamp buffalo (Bubalus bubalis carabauesis) conservation in Jambi Province, Indonesia
Authors: Syarifuddin Hutwan , Afdal Muhammad , Yurleni Yurleni  , Hamidah Afreni , Devitriano Dodi , Poy Tee Tuan 
Published: June 2024

Abstract
The objective of this study is to analyze the sustainability of swamp buffalo cultivation and develop decision-making strategies. Data were collected through focus group discussions with key informants in swamp buffalo cultivation and surveys of buffalo farmers in three regencies in Jambi Province. This study examines 37 attributes contained in four dimensions: ecological, economic, social, and technological dimensions. Data were analyzed using multidimensional scaling through the Rapid appraisal for buffalo technique and analytical hierarchy process (AHP) The results showed that the sustainability index of swamp buffalo cultivation in Sarolangun Regency was 59.39%, Batanghari 58.23%, and Tebo 55.93%. This study identified 12 leverage attributes obtained from 37 attributes that affect the sustainability of swamp buffalo, i.e., forage feed, agricultural waste, land use, agricultural infrastructure, land ownership, buffalo manure, buffalo ownership, livestock motivation, environmental impact, agricultural waste treatment, land processing, and post-harvest technology. Then, from the results of four-dimensional weighting with 12 attributes using AHP, there are 5 alternative strategies in decision making, namely, (1) build internet network infrastructure, (2) determine the number of livestock that can be raised in an area, (3) establish buffalo farming institutions, (4) prevent land use conflicts, and (5) increase farmer participation in raising buffalo livestock. This research provides input to policy makers to develop swamp buffalo cultivation by considering ecological, economic, social, and technological dimensions.
The Important Of Digital Accounting And Indonesian Government Incentives In Strengthening MSMEs’ Performance During the COVID-19 Pandemic
Authors: Apriyanti Hani Werdi , Budiman Judi 
Published: June 2024

Purpose: This paper provides a discussion of how financial access, tax incentives, MSMEs’ social assistance programs, accounting skills, and digital accounting utilization affects the MSMEs’ performance, during the COVID-19 pandemicMethod: The data was generated by a questionnaire sent to the food and beverage MSME sector in Semarang City, Central Java, Indonesia. The population in this study was 17.602 MSME in Semarang City, Central Java, Indonesia. The sample was 261 MSMEs in the food and beverage MSMEs sector obtained using a convenience sampling technique. Descriptive statistics, data quality tests, classic assumption tests, regression analyses, and hypotheses were tested with SPSS 25 software. Findings: Based on the hypotheses tests, the results show that accounting skills, digital accounting, and financial access have a significant positive effect on MSMEs’ Performance during Pandemic COVID-19 in Semarang. While tax incentives and MSMEs’ social assistance programs do not affect on MSMEs’ performance during the pandemic.Novelty: This study provides a unique detailed examination of actual practice and an indication of the future trend in digital accounting for MSMEs, and the role of government incentives to assist the MSME’s performance during the pandemic.
Cyber Risk Management Disclosure of State-Owned Enterprises
Authors: Sari Yeni Priatna , Suhardjanto Djoko , Probohudono Agung Nur , Honggowati Setianingtyas 
Published: June 2024

Purpose:The purpose of this research is to compile a cyber risk management disclosure index of State-Owned Enterprises (SOEs). This index is used to provide an overview of the disclosures that are expected by the stakeholders which are disclosed in the annual report of SOEs. Disclosure of cyber risk management is important for a business entity to show that the entity has readiness in facing digital technology which is one of the keys to the company's success.Method:The research method used is mixed method. The type of data is primary data sourced from Forum Group Discussion (FGD) inviting SOE Directors, audit committees, investors, risk management practitioners, and academics on how important the cyber risk management disclosure items formulated earlier are. Thirty corporate and SOE practitioners have been interviewed and internal auditor practitioners in SOEs have been sources of validity. The steps in compiling the index are first collecting cyber risk management disclosure items from the previous research and looking at ISO 31000 provisions regarding risk management.Findings: The result of this study is the composition of the cyber risk management disclosure index as many as 18 (eighteen) items with weighting on each disclosure item.Novelty:The novelty of this study is the formulation of a cyber risk management measurement index which is very important in relation to risk management in a company. This research is important to be carried out as a formulation of indicators for cyber risk management management carried out by the company. Researchers anticipate that this cyber risk management disclosure index will help the government create disclosure items for cyber risk management and serve as a norm for disclosing SOE cyber risk management in its annual report.