bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical value of neuroimaging indicators of intracranial hypertension in patients with cerebral venous thrombosis
Authors: Schuchardt Florian F. , Lützen Niklas , Küchlin Sebastian , Reich Michael , Lagrèze Wolf A. , Mast Hansjörg , Weigel Matthias , Meckel Stephan , Urbach Horst , Weiller Cornelius , Harloff Andreas , Demerath Theo 
Published: April 2024

Abstract
Purpose
Intracranial hypertension (IH) frequently complicates cerebral venous thrombosis (CVT). Distinct neuroimaging findings are associated with IH, yet their discriminative power, reversibility and factors favoring normalization in prospective CVT patients are unknown. We determined test performance measures of neuroimaging signs in acute CVT patients, their longitudinal change under anticoagulation, association with IH at baseline and with recanalization at follow-up.

Methods
We included 26 consecutive acute CVT patients and 26 healthy controls. Patients were classified as having IH based on CSF pressure > 25 cmH2O and/or papilledema on ophthalmological examination or ocular MRI. We assessed optic nerve sheath diameter (ONSD), optic nerve tortuousity, bulbar flattening, lateral and IVth ventricle size, pituitary configuration at baseline and follow-up, and their association with IH and venous recanalization.

Results
46% of CVT patients had IH. ONSD enlargement > 5.8 mm, optic nerve tortuousity and pituitary grade ≥ III had highest sensitivity, ocular bulb flattening and pituitary grade ≥ III highest specificity for IH. Only ONSD reliably discriminated IH at baseline. Recanalization was significantly associated with regressive ONSD and pituitary grade. Other neuroimaging signs tended to regress with recanalization. After treatment, 184.9 ± 44.7 days after diagnosis, bulbar flattening resolved, whereas compared with controls ONSD enlargement (p < 0.001) and partially empty sella (p = 0.017), among other indicators, persisted.

Conclusion
ONSD and pituitary grading have a high diagnostic value in diagnosing and monitoring CVT-associated IH. Given their limited sensitivity during early CVT and potentially persistent alterations following IH, neuroimaging indicators can neither replace CSF pressure measurement in diagnosing IH, nor determine the duration of anticoagulation.
Modular metabolic engineering of Bacillus amyloliquefaciens for high-level production of green biosurfactant iturin A
Authors: She Menglin , Zhou Huijuan , Dong Wanrong , Xu Yuxiang , Gao Lin , Gao Jiaming , Yang Yong , Yang Zhifan , Cai Dongbo , Chen Shouwen 
Published: April 2024

Abstract
As a kind of biosurfactants, iturin A has attracted people’s wide attentions due to their features of biodegradability, environmentally friendly, etc.; however, high production cost limited its extensive application, and the aim of this research wants to improve iturin A production in Bacillus amyloliquefaciens. Firstly, dual promoter was applied to strengthen iturin A synthetase expression, and its yield was increased to 1.25 g/L. Subsequently, original 5′-UTRs of downstream genes (ituA, ituB, and ituC) in iturin A synthetase cluster were optimized, which significantly increased mRNA secondary stability, and iturin A yield produced by resultant strain HZ-T3 reached 2.32 g/L. Secondly, synthetic pathway of α-glucosidase inhibitor 1-deoxynojirimycin was blocked to improve substrate corn starch utilization, and iturin A yield was increased by 34.91% to 3.13 g/L. Thirdly, efficient precursor (fatty acids, Ser, and Pro) supplies were proven as the critical role in iturin A synthesis, and 5.52 g/L iturin A was attained by resultant strain, through overexpressing yngH, serC, and introducing ocD. Meanwhile, genes responsible for poly-γ-glutamic acid, extracellular polysaccharide, and surfactin syntheses were deleted, which led to a 30.98% increase of iturin A yield. Finally, lipopeptide transporters were screened, and iturin A yield was increased by 17.98% in SwrC overexpression strain, reached 8.53 g/L, which is the highest yield of iturin A ever reported. This study laid a foundation for industrial production and application development of iturin A, and provided the guidance of metabolic engineering breeding for efficient production of other metabolites synthesized by non-ribosomal peptide synthetase.

Key points
• Optimizing 5′-UTR is an effective tactics to regulate synthetase cluster expression.
• Blocking 1-DNJ synthesis benefited corn starch utilization and iturin A production.
• The iturin A yield attained in this work was the highest yield reported so far.
Gelation of PU elastomers: rheological characterization for liquid additive manufacturing
Authors: Wang Peng , Winter H. Henning , Wagner Manfred H. , Auhl Dietmar 
Published: April 2024

AbstractPolyurethane (PU) is a versatile polymer with many applications in a wide range of products. A novel 3D printing technology called liquid additive manufacturing (LAM) extended its possibilities by generating PU elastomers with gradient properties in continuous processing. LAM, being a relatively new technique, has not been extensively researched, particularly in terms of the curing behavior of the liquid resin. In this work, we investigated the effect of composition on gelation time tGP as measured by time-resolved mechanical spectroscopy (TRMS) and analyzed using the Winter–Chambon criterion with the assistance of the IRIS software. This method is more accurate than the previous approach, which involved time sweeps with a constant frequency. It was found that the gel time tGP first decreased and then increased with increasing polyol ratio, ranging from 231 to 378 min. Furthermore, the crosslink densities of the different PU elastomers measured from the rheological and tensile tests were calculated and compared based on the theory of rubber elasticity. The crosslink density decreased with an increasing polyol ratio in both methods. However, the crosslink density values obtained from the rheological measurements were higher than those from the tensile tests. These findings demonstrate that adjusting the polyol ratio is an effective means of achieving gradient properties. The composition effects we measured offer valuable insights for the design of LAM–PU elastomers.
The effect of potassium on aluminous phase stability in the lower mantle
Authors: Rogmann Elena-Marie , Jennings Eleanor S. , Ross Jennifer , Miyajima Nobuyoshi , Walter Michael J. , Kohn Simon C. , Lord Oliver T. 
Published: April 2024

AbstractThe aluminous calcium-ferrite type phase (CF) and new aluminous phase (NAL) are thought to hold the excess alumina produced by the decomposition of garnet in MORB compositions in the lower mantle. The respective stabilities of CF and NAL in the nepheline-spinel binary (NaAlSiO$$_{4}$$

4

–MgAl$$_{2}$$

2

O$$_{4}$$

4

) are well established. However with the addition of further components the phase relations at lower mantle conditions remain unclear. Here we investigate a range of compositions around the nepheline apex of the nepheline-kalsilite-spinel compositional join (NaAlSiO$$_{4}$$

4

–KAlSiO$$_{4}$$

4

–MgAl$$_{2}$$

2

O$$_{4}$$

4

) at 28–78 GPa and 2000 K. Our experiments indicate that even small amounts of a kalsilite (KAlSiO$$_{4}$$

4

) component dramatically impact phase relations. We find NAL to be stable up to at least 71 GPa in potassium-bearing compositions. This demonstrates the stabilizing effect of potassium on NAL, because NAL is not observed at pressures above 48 GPa on the nepheline-spinel binary. We also observe a broadening of the CF stability field to incorporate larger amounts of potassium with increasing pressure. For pressures below 50 GPa only minor amounts ($$<0.011(1)\frac{K}{K+Na+Mg}$$

<
0.011

(
1
)

K

K
+
N
a
+
M
g

) of potassium are soluble in CF, whereas at 68 GPa, we find a solubility in CF of at least $$0.088(3)\frac{K}{K+Na+Mg}$$

0.088

(
3
)

K

K
+
N
a
+
M
g

. This indicates that CF and NAL are suitable hosts of the alkali content of MORB compositions at lower mantle conditions. For sedimentary compositions at lower mantle pressures, we expect K-Hollandite to be stable in addition to CF and NAL for pressures of 28–48 GPa, based on our simplified compositions.
Robotic assisted surgery reduces ergonomic risk during minimally invasive colorectal resection: the VOLCANO randomised controlled trial
Authors: Dixon Frances , Vitish-Sharma Parveen , Khanna Achal , Keeler Barrie D. ,   on behalf of the VOLCANO Trial Group, Qureshi Adnan , Singh Anjana , Hemandas Anil , O’Hara Richard , Wren Lynn , Oshiotse Santos , George Susan 
Published: April 2024

Abstract
Purpose
Minimally invasive surgery benefits patients but poor operating ergonomics causes musculoskeletal injuries in surgeons. This randomised controlled trial aims to assess whether robotic-assisted surgery with the open-console Versius® system can reduce surgeons’ ergonomic risks during major colorectal resections.

Methods
Prospectively registered at ClinicalTrials.gov (NCT05262296) in March 2022. Adult patients requiring a minimally invasive colorectal resection were potentially eligible. Photographs taken at 2-min intervals were analysed using the objective Rapid Entire Body Assessment (REBA) posture analysis scale to calculate intraoperative surgeon ergonomic risk. Secondary outcomes included team communication (Oxford NOTECHS II), surgeon cognitive strain (modified NASA-TLX scale), and clinical outcomes.

Results
Sixty patients were randomised in a 2:1 ratio (40 robot, 20 laparoscopic). Mean age was 65yrs and 34 (57%) were male. Body Mass Index did not differ between the 2 groups (overall mean 29.0 ± 5) and there were equal proportions of left and right-colonic resections.
REBA was significantly lower in the robotic arm (median robot REBA score 3 vs lap REBA 5 [p < 0.001]), equating to an injury risk category drop from “medium” to “low risk”. There were no significant differences in team communication, operative duration, or patient outcomes. Surgeon cognitive strain was lower in robotic cases (mean robot 32.4 ± 10.3 vs lap 45.6 ± 14.3 [p < 0.001]).

Conclusions
This trial demonstrates that robotic surgery with an open-console system reduces ergonomic risk scores and cognitive strain during colorectal resections, with no apparent detriment to team communication. This may therefore be a safe & feasible solution to the increasing problem of work-related musculoskeletal injuries in surgeons.
Gastric perforation biopsy: is it obsolete?
Authors: Steyn Petre Francois , Karusseit Otto 
Published: April 2024

Abstract
Purpose
The aim of the study was to test the established hypothesis that biopsies of spontaneous gastric perforations should be taken to rule out cancer.

Methods
A prospective observational study was performed. Consecutive patients with spontaneous gastric perforation were included. Biopsies of the edges of the perforation were submitted for histological evaluation. The epithelial type as well as the nature of the pathology were evaluated.

Results
Sixty-eight patients were included. Eight (12%) biopsies revealed duodenal origin. Sixty (88%) biopsies revealed gastric mucosa of which 33 (48%) could be specifically typed. All biopsies revealed benign ulceration. No malignancies were detected in these biopsies or on subsequent gastroscopic follow up.

Conclusion
This study suggests that routine intraoperative biopsy of gastric perforation may be questioned. Biopsy is probably better performed endoscopically after recovery.
Runtime Analysis of Competitive Co-evolutionary Algorithms for Maximin Optimisation of a Bilinear Function
Authors: Lehre Per Kristian 
Published: April 2024

AbstractCo-evolutionary algorithms have a wide range of applications, such as in hardware design, evolution of strategies for board games, and patching software bugs. However, these algorithms are poorly understood and applications are often limited by pathological behaviour, such as loss of gradient, relative over-generalisation, and mediocre objective stasis. It is an open challenge to develop a theory that can predict when co-evolutionary algorithms find solutions efficiently and reliable. This paper provides a first step in developing runtime analysis for population-based competitive co-evolutionary algorithms. We provide a mathematical framework for describing and reasoning about the performance of co-evolutionary processes. To illustrate the framework, we introduce a population-based co-evolutionary algorithm called PDCoEA, and prove that it obtains a solution to a bilinear maximin optimisation problem in expected polynomial time. Finally, we describe settings where PDCoEA needs exponential time with overwhelmingly high probability to obtain a solution.
Deep learning tool: reconstruction of long missing climate data based on spatio-temporal multilayer perceptron
Authors: Xu Tianxin , Zhang Yan , Zhang Chenjia , Abodoukayimu Abulimiti , Ma Daokun 
Published: April 2024

AbstractLong-term monitoring of climate data is significant for grasping the law and development trend of climate change and guaranteeing food security. However, some weather stations lack monitoring data for even decades. In this study, 62 years of historical monitoring data from 105 weather stations in Xinjiang were used for missing sequence prediction, validating proposed data reconstruction tool. First of all, study area was divided into three parts according to the climatic characteristics and geographical locations. A spatio-temporal multilayer perceptron (MLP) was established to reconstruct meteorological data with three time scales (Short term, cycle and long term) and one spatio dimension as inputing (rolling predictions, one step predicts one day), filling in long sequence blank data. By designing an end-to-end model to autonomously detect the locations of missing data and make rolling predictions,we obtained complete meteorological monitoring data of Xinjiang from 1961 to 2022. Seven kinds of parameter reconstructed include maximum temperature (Max_T), minimum temperature (Min_T), mean temperature (Ave _ T), average water vapor pressure (Ave _ WVP), relative humidity (Ave _ RH), average wind speed (10 m Ave _ WS), and sunshine duration (Sun_H). Contrasted the prediction accuracy of the model with general MLP and LSTM, results shows that, in the seven types of parameters, designed spatio-temporal MLP decreases MAE and MSE by 7.61% and 4.80% respectively. The quality of reconstructed data was evaluated by calculating correlation coefficient with the monitored sequences of nearest station,determining the applicable meteorological parameters of the model according to the results. Results show that,proposed model reached satisfied average correlation coefficient for Max_T, Min_T, Ave _ T and Ave _ WVP parameters are 0.969, 0.961, 0.971 and 0.942 respectively. The average correlation coefficient of Sun_H and Ave _ RH are 0.720 and 0.789. Although it is difficult to predict extreme values, it can still capture the period and trend; the reconstruction effect of 10 m Ave _ WS is poor, with the average similarity of 0.488. Proposed method is applicable to reconstruct Max_T, Min_T, Ave _ T and Ave _ WVP, but not recommended to reconstruct Sun_H, Ave _ RH and Ave _ WS.
Bleaching versus color change resistant adhesive in the discoloration of bracket-bonded tooth surfaces: an in vitro study
Authors: Karadeniz Hasan , Yazıcıoğlu Sabahat 
Published: April 2024

Abstract
Objectives
The aim of this study was to compare the effect of office bleaching of teeth bonded with Transbond XTTM (3M Unitek, Monrovia, CA, USA) (TRXT) and the use of color change resistant Orthocem (FGM, Joinville, Brazil) in bracket bonding on coffee-induced enamel discoloration.

Materials and methods
Eighty premolars were distributed in equal numbers (n = 20) to group 1 (TRXT + distilled water), group 2 (TRXT + coffee solution), group 3 (TRXT + coffee solution + bleaching), and group 4 (Orthocem + coffee solution). Color was measured using a SpectroShade Micro (MHT, International, Verona, Italy) device at the beginning (T0), after coloring (T1), after bleaching (T1B), and after debonding (T2). ΔE color change values were calculated as T1-T0, T1B-T0 and T2-T0 differences. The conformity of the data to the normal distribution was examined with the Shapiro–Wilk test. Multiple comparisons were made with Tamhane’s T2 test and Tukey’s HSD test using one-way analysis of variance in the comparison of normally distributed data, and multiple comparisons were made with Dunn’s test using the Kruskal–Wallis H test for comparison of non-normally distributed data. The significance level was set at p < 0.050.

Results
A statistically significant (p < 0.001) difference was found between the T1-T0 and T2-T0 stages for group 1–4 ΔE values. A statistically significant (p < 0.001) difference was also found when the T1B-T0 ΔE values of group 3 were compared with the T1-T0 ΔE values of groups 1, 2, and 4.

Conclusions
After coffee-induced enamel discoloration, bleaching of teeth bonded with TRXT produced acceptable color difference of the incisal, middle, and gingival regions of the crown. In teeth bonded with Orthocem, acceptable color difference was seen only in the middle of the crown.

Clinical relevance
The presented study will guide the clinician on how enamel discoloration side effect of fixed orthodontic appliance can reduce.
Empirical analysis of the market structure of the Hungarian bank market
Authors: Szádoczkiné Varga Veronika , Madari Zoltán 
Published: April 2024

AbstractThis paper analyzes the market structure of the Hungarian bank market and the effects of the financial crisis of 2008 on it. With a static and a dynamic panel model we estimate the elasticity of total revenues with respect to changes in input prices so that we can determine the market structure based on the Panzar and Rosse methodology for the period between 2003 and 2020. We test the input price elasticity according to the balance sheet and profit and loss data of the top 13 companies. The results show that the Hungarian bank market was a monopolistic competition or a monopoly market in long run equilibrium. To see the effects of the financial crisis we use three subsamples, furthermore we estimate and test the H-statistic with a fixed effect model. During the examined period the level of factor price elasticity increased in time.
Association of soluble suppression of tumorigenicity 2 with mortality and adverse outcomes in chronic kidney disease: a systematic review and meta-analysis
Authors: Bellos Ioannis , Marinaki Smaragdi , Lagiou Pagona , Benetou Vassiliki 
Published: April 2024

Abstract
Background
Early risk stratification is necessary to prevent chronic kidney disease progression and complications. This systematic review aims to evaluate the association of soluble suppression of tumorigenicity 2 (sST2), a member of the interleukin-1 receptor family, with all-cause mortality, cardiovascular disease and renal function deterioration among chronic kidney disease patients.

Methods
PubMed, Scopus, Web of Science, CENTRAL and Google Scholar were systematically searched from inception to December 20, 2023. Cohort studies examining the prognostic role of sST2 levels in pre-dialysis and dialysis patients were included. In case of 3 or more studies per outcome, conventional and dose–response meta-analyses were conducted.

Results
Overall, 21 studies were included comprising 15,100 patients. In pre-dialysis patients, the qualitative synthesis of studies suggested that high sST2 is associated with significantly increased all-cause mortality, while evidence regarding cardiovascular events or kidney disease progression was conflicting. In the dialysis population, high sST2 was linked to an elevated risk of all-cause (Hazard ratio-HR: 3.00, 95% confidence intervals-CI: 1.95–4.61) and cardiovascular (HR: 2.38, 95% CI: 1.69–3.34) mortality. Dose–response meta-analysis suggested a log-linear association of sST2 with both all-cause (χ2: 34.65, p value < 0.001) and cardiovascular (χ2: 29.14, p value < 0.001) mortality, whereas findings regarding cardiovascular events were limited with mixed results.

Conclusions
High sST2 values are associated with an increased risk of all-cause mortality in pre-dialysis and dialysis patients, as well as with an elevated risk of cardiovascular mortality in the dialysis population. Further studies are needed to elucidate its potential association with cardiovascular events and kidney disease progression.
The chemical basis of seawater therapies: a review
Authors: Costanzo Michele , De Giglio Maria Anna Rachele , Gilhen-Baker Melinda , Roviello Giovanni Nicola 
Published: April 2024

AbstractThe rising number of diseases and deaths caused by pollution and modern lifestyle habits is a growing societal concern. Marine ecosystems are both victim to this human behaviour as a recipient of human pollution as well as being a source of medicinal chemicals which can cure a variety of diseases. In this paper, we review the chemical basis of water-based treatments and their effects on human health, while focusing on the threats to marine ecosystems and the potential benefits of balneotherapy, thalassotherapy, and bioactive chemical species. We found that seawater has potential benefits for skin health, demonstrating emollient properties, protection against skin barrier disruption, and inhibition of atopic dermatitis-like skin lesions. We present the putative mechanisms by which minerals, salts, and marine organic matter can slow down disease progression, through their numerous activities, such as anti-inflammatory, antioxidant, and wound healing properties. Water-living organisms also have an impact on such mechanisms by producing biologically active compounds with beneficial effects on human health.
Forest fuel extraction does not affect macrolichens on deadwood substrates, but only if coarse woody debris is not collected
Authors: Purhonen Jenna , Nirhamo Aleksi , Jäntti Mari , Halme Panu 
Published: April 2024

AbstractThe increasing use of forest fuels poses risks to biodiversity. Lichens that grow on deadwood may be affected as fuel extraction removes their substrates. We surveyed deadwood and macrolichens on deadwood in two types of clearcuts: sites in which forest fuels, stumps and slash, had been extracted, and standard clearcut sites, i.e. control sites with no fuel extraction. Extraction sites had 52% lower deadwood volume (44.3 m³/ha vs. 21.4 m³/ha) and 36% less deadwood surface area. However, the negative impact of fuel extraction on macrolichen species richness was low: 21.4 and 16.9 species on average were found in control and extraction sites, respectively. We found a clear positive relationship between macrolichen species richness and the surface area of logs, which are usually not targeted by forest fuel extraction. Species composition varied more among extraction sites than control sites and differed between all the studied deadwood types. Species of Cladonia were associated with stumps, while species in the family Parmeliaceae were associated with logs. Slash was of negligible importance to macrolichens. Stumps may hold value, particularly if large-sized deadwood is otherwise not available. Thus, we conclude that the extraction of slash poses no threat to macrolichen diversity, whereas extensive extraction of stumps can cause losses in lichen diversity. The loss of coarse woody debris during forest fuel extraction has negative effects on lichen diversity and should be avoided.