bluuebunny/crossref_metadata_2025_split huggingface dataset:
Duloxetine and care management treatment of older adults with comorbid major depressive disorder and chronic low back pain: results of an open‐label pilot study
Authors: Karp Jordan F. , Weiner Debra K. , Dew Mary A. , Begley Amy , Miller Mark D. , Reynolds Charles F. 
Published: September 2009

AbstractObjectiveIn older adults, major depressive disorder (MDD) and chronic low back pain (CLBP) are common and mutually exacerbating. We predicted that duloxetine pharmacotherapy and Depression and Pain Care Management (DPCM) would result in (1) significant improvement in MDD and CLBP and (2) significant improvements in health‐related quality of life, anxiety, disability, self‐efficacy, and sleep quality.Design and InterventionTwelve week open‐label study using duloxetine up to 120 mg/day + DPCM.SettingOutpatient late‐life depression research clinic.PatientsThirty community‐dwelling adults >60 years old.Outcome MeasuresMontgomery Asberg Depression Rating Scale (MADRS) and McGill Pain Questionnaire‐Short Form (MPQ‐SF).Results46.7% (n = 14) of the sample had a depression remission. All subjects who met criteria for the depression remission also had a pain response. 93.3% (n = 28) had a significant pain response. Of the subjects who met criteria for a low back pain response, 50% (n = 14) also met criteria for the depression remission. The mean time to depression remission was 7.6 (SE = 0.6) weeks. The mean time to pain response was 2.8 (SE = 0.5) weeks. There were significant improvements in mental health‐related quality of life, anxiety, sleep quality, somatic complaints, and both self‐efficacy for pain management and for coping with symptoms. Physical health‐related quality of life, back pain‐related disability, and self‐efficacy for physical functioning did not improve.ConclusionsSerotonin and norepinephrine reuptake inhibitors like duloxetine delivered with DPCM may be a good choice to treat these linked conditions in older adults. Treatments that target low self‐efficacy for physical function and improving disability may further increase response rates. Copyright © 2009 John Wiley & Sons, Ltd.
Intramolecular C‐thiocarbamoylation of aroxy(isothiocyanato)phosphonium salts
Authors: Smalii R. V. , Marchenko A. P. , Koidan Y. N. , Chaikovskaya A. A. , Pinchuk A. M. , Tolmachev A. A. 
Published: September 2009

AbstractIsothiocyanatophosphonium salts bearing an aroxy group at the phosphorus atom have been obtained for the first time. As found, these compounds undergo an intramolecular heterocyclization to give hitherto unknown benzoxazaphosphininethiones or cyanoiminophosphoranes, according to the nature of the substituents on the aryl ring. © 2008 Wiley Periodicals, Inc. Heteroatom Chem 19:667–670, 2008; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/hc.20491
Efficient method of cyclic imides synthesis under ozone influence by the example of ε‐caprolactam oxidation reaction
Authors: Alekseeva Olga , Konstantinova Marina , Rasumovskii Stanislav 
Published: September 2009

AbstractThe process of ε‐caprolactam oxidation by ozone in a CCl4 solution was investigated. Stoichiometric coefficient (1:1) and the mechanism of oxidation were identified. The composition and structure of the ozonolysis reaction products and the ozone attack on the caprolactam molecule were determined by IR and 1H NMR spectroscopy methods, as well as using thin‐layer chromatography. It was found that the ozonolysis reaction is rather selective. The main reaction product—azepane‐2,7‐dione (Scharf et al., Angew Makromol Chem 1979, 79, 193)—was formed with a yield of more than 90% and can be used as an intermediate during the production of commercially important antibiotics. Kinetics of the reaction obeyed the bimolecular law, the effective rate constant of the reaction in the CCl4 solution is equal to kr = 22.7 l/(mol s). The method of fast conversion of lactame to cycloimide under the ozone influence is reported. © 2008 Wiley Periodicals, Inc. Heteroatom Chem 19:661–666, 2008; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/hc.20492
Ni(II), Cu(II), and Zn(II) complexes of tetradentate schiff base containing two thiadiazoles units: Structural, spectroscopic, magnetic properties, and molecular modeling studies
Authors: Serbest Kerim , Kayi Hakan , Er Mustafa , Sancak Kemal , Değirmencioğlu İsmail 
Published: September 2009

AbstractFour new mononuclear metal complexes with a mononucleating Schiff base ligand containing two thiadiazoles units have been synthesized. The ligand and metal complexes were characterized by elemental analyses, IR, 1H, and 13C NMR, UV–vis, ESR, electrospray ionization mass spectra, and magnetic susceptibility measurements. Electronic spectra, magnetic susceptibility measurement, and molecular modeling studies support octahedral geometry around the Ni(II), Cu(II), and Zn(II) ions. The magnetic properties were investigated, and ferromagnetic coupling is observed in Cu(II) and Ni(II) complexes. In addition, total energy and heat of formation calculated for conformers of the Schiff base ligand by the semiempirical AM1 calculations have shown that E,Z‐isomer of the ligand is more stable (about 5.3 kcal/mol) than E,E‐ and Z,Z‐isomers. © 2008 Wiley Periodicals, Inc. Heteroatom Chem 19:700–712, 2008; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/hc.20496
A simple and efficient preparation of pyrazolo[3,4‐b]‐pyridine derivatives through an unexpected reaction of cyanothioacetamide under microwave irradiation
Authors: Fan Xuesen , Wang Xia , Zhang Xinying , Li Xiaoyan , Qu Guirong 
Published: September 2009

AbstractAn unexpected multicomponent reaction of cyanothioacetamide with aromatic aldehydes and aminopyrazole under MWI was found and reported. It turned out to be an efficient and simple procedure for the preparation of pyrazolo[3,4‐b]pyridine derivatives. The structure of the product was characterized by IR, MS, 1H and 13C NMR, COSY and NOESY spectroscopy, X‐ray crystallographic analysis, and by comparison with the authentic sample prepared with the known procedure. © 2008 Wiley Periodicals, Inc. Heteroatom Chem 19:694–699, 2008; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/hc.20497
Synthesis and characterization of novel (9H‐fluoren‐9‐ylamino) carbonylaminomethylphosphonic acid
Authors: Todorov Petar , Naydenova Emilia , Popova Julita , Troev Kolio 
Published: September 2009

AbstractThe new α‐aminophosphonic acids are synthesized, reacting (9H‐fluoren‐9‐yl)urea with formaldehyde and phosphorus trichloride. (9H‐Fluoren‐9‐yl)urea was prepared from spiro(fluoren‐9,4′‐imidazolidine)‐2′,5′‐dione by alkaline hydrolysis with Ba(OH)2. The structure of the title compounds was proved by means of IR, 1H, 13C, and 31P NMR spectroscopy. © 2008 Wiley Periodicals, Inc. Heteroatom Chem 19:719–722, 2008; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/hc.20500
A facile synthesis of stable phosphorus ylides derived from 3,6‐dibromocarbazole and kinetic investigation of the reactions by UV spectrophotometry technique
Authors: Habibi‐Khorassani Sayyed Mostafa , Maghsoodlou Malek Taher , zakarianezhad Mohammad , Nassiri Mahmoud , Kazemian Mohammad Amin , Karimi Puya 
Published: September 2009

AbstractStable crystalline phosphorus ylides were obtained in excellent yields from the 1:1:1 addition reaction between triphenylphosphine and dialkyl acetylenedicarboxylates, in the presence of NH‐acid, such as 3,6‐dibromocarbazole. These stable ylides exist in solution as a mixture of two geometrical isomers as a result of restricted rotation around the carbon–carbon partial double bond, resulting from the conjugation of the ylide moiety with the adjacent carbonyl group. To determine the kinetic parameters of the reactions, they were monitored by UV spectrophotometry. The second‐order fits were drawn, and the values of the second‐order rate constant (k2) were calculated using standard equations within the program. At the temperature range studied, the dependence of the second‐order rate constant (ln k2) on reciprocal temperature was in a good agreement with the Arrhenius equation. This provided the relevant plots to calculate the activation energy of all reactions. Furthermore, useful information was obtained from studies of the effect of solvent, structure of reactants (different alkyl groups within the dialkyl acetylenedicarboxylates), and also the concentration of reactants on the rate of reactions. The proposed mechanism was confirmed according to the obtained results and a steady‐state approximation and the first step (k2) of reaction was recognized as a rate‐determining step on the basis of the experimental data. © 2008 Wiley Periodicals, Inc. Heteroatom Chem 19:723–732, 2008; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/hc.20501
Scale‐dependent fiber kinematics of elastomeric electrospun scaffolds for soft tissue engineering
Authors: Stella John A. , Wagner William R. , Sacks Michael S. 
Published: September 2009

AbstractElectrospun poly(ester urethane)urea (PEUU) scaffolds contain complex multiscale hierarchical structures that work simultaneously to produce unique macrolevel mechanical behaviors. In this study, we focused on quantifying key multiscale scaffold structural features to elucidate the mechanisms by which these scaffolds function to emulate native tissue tensile behavior. Fiber alignment was modulated via increasing rotational velocity of the collecting mandrel, and the resultant specimens were imaged using SEM under controlled biaxial strain. From the SEM images, fiber splay, tortuosity, and diameter were quantified in the unstrained and deformed configurations. Results indicated that not only fiber alignment increased with mandrel velocity but also, paradoxically, tortuosity increased concurrently with mandrel velocity and was highly correlated with fiber orientation. At microlevel scales (1–10 μm), local scaffold deformation behavior was observed to be highly heterogeneous, while increasing the scale resulted in an increasingly homogenous strain field. From our comprehensive measurements, we determined that the transition scale from heterogenous to homogeneous‐like behavior to be ∼1 mm. Moreover, while electrospun PEUU scaffolds exhibit complex deformations at the microscale, the larger scale structural features of the fibrous network allow them to behave as long‐fiber composites that deform in an affine‐like manner. This study underscores the importance of understanding the structure–function relationships in elastomeric fibrous scaffolds, and in particular allowed us to link microscale deformations with mechanisms that allow them to successfully simulate soft tissue mechanical behavior. © 2009 Wiley Periodicals, Inc. J Biomed Mater Res, 2010
Electroactivity and biocompatibility of polypyrrole‐hyaluronic acid multi‐walled carbon nanotube composite
Authors: Pelto Jani , Haimi Suvi , Puukilainen Esa , Whitten Philip G. , Spinks Geoffrey M. , Bahrami‐Samani Mehrdad , Ritala Mikko , Vuorinen Tommi 
Published: September 2009

AbstractElectroactivity of polypyrrole hyaluronic acid, electropolymerized in the presence of oxidized carbon nanotubes (PPyHA‐CNT) was studied in situ by electrochemical atomic force microscopy (EC‐AFM) in physiological electrolyte solution. In situ Raman spectroscopic and quartz crystal microbalance (QCM) studies were conducted on layers of the polymer grown on AT‐cut 5 MHz quartz crystals. Human adipose stem cell (ASC) attachment and viability were studied by Live/Dead staining, and the proliferation was evaluated by WST‐1 Cell proliferation assay for polypyrrole samples electropolymerized on titanium. According to cyclic voltammetry, the measured specific capacitance of the material on gold is roughly 20% of the reference polypyrrole dodecylbenzene sulfonate (PPyDBS). Electrochemical‐QCM (EC‐QCM) analysis of a 210‐nm thick film reveals that the material is very soft G′∼100 kPa and swells upon reduction. EC‐AFM of samples polymerized on microelectrodes show that there are areas of varying electroactivity, especially for samples without a hydrophopic backing PPyDBS layer. AFM line scans show typically 20–25% thickness change during electrochemical reduction. Raman spectroscopic analysis suggests that the material supports noticeable polaron conduction. Biocompatibility study of the PPyHA‐CNT on titanium with adipose stem cells showed equal or better cell attachment, viability, and proliferation compared with the reference polylactide. © 2009 Wiley Periodicals, Inc. J Biomed Mater Res, 2010
Laser secondary neutral mass spectrometry for copper detection in micro‐scale biopsies
Authors: Kriegeskotte C. , Cantz T. , Haberland J. , Zibert A. , Haier J. , Köhler G. , Schöler H. R. , Schmidt H. H.‐J. , Arlinghaus H. F. 
Published: September 2009

AbstractDisease progression and clinical diagnostics of a number of hereditable metabolic diseases are determined by organ involvement in disturbed deposition of certain molecules. Current clinical imaging is unable to visualize this maldistribution with sufficient specificity and sensitivity, such as in Wilson's disease. The quest for understanding cellular Cu distribution in these patients requires element‐ and molecule‐specific images with nanometer‐scale spatial resolution. We have used a new cryo‐mass spectrometric instrument with an integrated cryosectioning chamber for preparation and analysis of frozen hydrated samples of Wilson's disease tissue. With laser post‐ionization secondary neutral mass spectrometry (laser‐SNMS), we were able to image Cu and other intrinsic elements and molecules in less than 1 mg of frozen hydrated liver tissue from a murine model of Wilson's disease. A 40–50 times higher Cu concentration was measured in the disease tissue as compared to the control mouse. Furthermore, major histomorphological changes were observed using this advanced nano‐science tool. The results showed that the combination of in‐vacuum cryosectioning and cryo‐laser‐SNMS technologies is particularly well suited for identifying specific cell structures and imaging trace element concentrations with subcellular resolution and upper‐parts‐per‐billion sensitivity in biological samples. This technology can provide a novel diagnostic tool for clinical applications in various diseases involving trace elements. Copyright © 2009 John Wiley & Sons, Ltd.
Quality of life in postoperative vestibular schwannoma patients
Authors: Cheng Sheila , Naidoo Yuresh , da Cruz Melville , Dexter Mark 
Published: September 2009

AbstractObjectives/Hypothesis:To quantify the postoperative quality of life (QOL) in patients following vestibular schwannoma surgery in a new multidisciplinary skull base unit.Study Design:Cross‐sectional study.Methods:The Australian Short Form 36 (SF‐36) quality of life health questionnaire was administered to 121 consecutive patients surgically treated for vestibular schwannoma between 1999 and 2007 at Westmead Hospital, New South Wales, Australia. QOL scores were calculated using a standardized process across the eight SF‐36 health domains and compared to sex‐ and age‐ matched healthy Australian population.Results:An 81% response rate (98 patients) was obtained. The postoperative QOL in vestibular schwannoma patients was significantly less than the appropriate matched healthy Australian population in one health domain of role physical limitation (P< .05). Analysis of preoperative patient factors (age, gender) and surgical factors such as tumor size (cutoff points of 15 mm or 25 mm) together with, surgical approach (translabyrinthine and retrosigmoid) showed no significant difference in QOL outcomes for each of these variables (P< .05).Conclusions:Results indicate that patients following vestibular schwannoma surgery reported near equivalent QOL as the healthy population. Advances in surgical techniques and experiences have minimized morbidities associated with vestibular schwannoma surgery. Significant physical role limitation encountered postoperatively may relate to facial nerve dysfunction, vestibular dysfunction, tinnitus or hearing loss that may persist after surgery. Careful patient selection, as well as, appropriate preoperative counselling, multidisciplinary follow‐up and rehabilitation should be offered to all surgical candidates. A measured approach should still be considered for patients with small, slow growing tumors with minimal symptoms. Laryngoscope, 2009
Retronasal olfactory function in Parkinson's disease
Authors: Landis Basile N. , Cao Van Hélène , Guinand Nils , Horvath Judit , Haehner Antje , Savva Elena , Hugentobler Marianne , Lacroix Jean‐Silvain , Burkhard Pierre R. 
Published: September 2009

AbstractObjectives/Hypothesis:Orthonasal olfaction is severely altered in PD patients. Retronasal olfactory function has been shown to be preserved under certain conditions even in the absence of orthonasal function. This study was undertaken to investigate retronasal versus orthonasal olfactory function in Parkinson's disease (PD).Study Design:Prospective study.Methods:A total of 45 PD patients (mean age, 61 years; range 26–82 years) underwent orthonasal olfactory testing with a standardized olfactory test (Sniffin' Sticks) and retronasal olfactory testing with a 10‐item identification kit based on aromatized powders.Results:Regarding orthonasal tests, all PD patients scored within the range of hyposmia and functional anosmia. The mean correct orthonasal identification score for PD patients was 56% ± 2.6%, and the mean retronasal identification rate was 60% ± 3%. There was no significant difference between ortho‐ and retronasal odor identification (P = .15).Conclusions:The present study shows that retronasal and orthonasal olfactory function are severely impaired in PD patients, and this impairment is of similar magnitude for both functions. The contribution of this finding to the food‐intake behavior of PD patients is discussed. Laryngoscope, 2009
Intake of Maillard reaction products reduces iron bioavailability in male adolescents
Authors: García Marta Mesías , Seiquer Isabel , Delgado‐Andrade Cristina , Galdó Gabriel , Navarro Maria Pilar 
Published: September 2009

AbstractThe effects of diets with different Maillard reaction products (MRPs) content on biological iron utilization were compared using in vitro/in vivo assays. Diets were rich (brown diet, BD) or poor (white diet) in MRP. In vitro studies included iron solubility after in vitro digestion of diets and iron transport across Caco‐2 cells. In the human assay 18 healthy adolescent males (11–14 years) participated in a 2‐wk randomized two‐period crossover trial. Subjects collected urine and faeces on the last 3 days of each dietary period, and fasting blood samples were obtained after periods. In vitro dietary iron availability was significantly lower with the BD than the white diet (9.52 and 12.92%, respectively), as a consequence of the lower iron solubility after the in vitro digestion, but not as a result of decreased transport of the remaining soluble iron. The BD consumption increased iron fecal excretion (∼1.4‐fold) and significantly decreased its bioavailability (∼2.7‐fold), mainly due to the effects found at digestive level. Serum biochemical parameters related to iron metabolism remained unaltered. It is concluded the presence of MRP in the diet negatively affects iron bioavailability. As iron deficiency may be related to learning impairment and to reductions of cognitive and physical functions, possible long‐term effects of excessive MRP intake during adolescence warrant attention.
Identification of 3‐hydroxy‐β‐damascone and related carotenoid‐derived aroma compounds as novel potent inducers of Nrf2‐mediated phase 2 response with concomitant anti‐inflammatory activity
Authors: Gerhäuser Clarissa , Klimo Karin , Hümmer Wolfgang , Hölzer Jana , Petermann Astrid , Garreta‐Rufas Antonio , Böhmer Frank‐D. , Schreier Peter 
Published: September 2009

AbstractStructural comparison of apple constituents with known inducers of phase two cytoprotective enzymes led to the identification of 3‐hydroxy‐β‐damascone and related carotenoid derived aroma compounds as potent inducers of NAD(P)H:quinone reductase (QR) activity. Damascone‐related compounds were found to be more potent inducers than ionone derivatives, with CD values (concentrations required to double the specific activity of QR in Hepa1c1c7 cell culture) in the range of 1.0–5.7 μM. QR induction by 3‐hydroxy‐β‐damascone was shown to be mediated via transcription factor Nrf2 signaling in transient transfection experiments. We further identified aroma compounds as potent inhibitors of LPS‐induced inducible nitric oxide synthase activity in Raw 264.7 cell culture. Again, damascone derivatives were most potent with half‐maximal inhibitory concentration values of 1.8–7.9 μM. These results reveal previously unrecognized cancer chemopreventive potential of aroma compounds such as β‐damascenone, 3‐hydroxy‐β‐damascone, and related substances, which may contribute to the cancer protective efficacy of apple products and other dietary sources in animal models.
Curcumin reduces oxidative and nitrative DNA damage through balancing of oxidant–antioxidant status in hamsters infected with Opisthorchis viverrini
Authors: Pinlaor Somchai , Yongvanit Puangrat , Prakobwong Suksanti , Kaewsamut Butsara , Khoontawad Jarinya , Pinlaor Porntip , Hiraku Yusuke 
Published: September 2009

AbstractOpisthorchis viverrini (OV) infection is endemic in northeastern Thailand. We have previously reported that OV infection induces oxidative and nitrative DNA damage via chronic inflammation, which contributes to the disease and cholangiocarcinogenesis. Here, we examined the effect of curcumin, an antioxidant, on pathogenesis in OV‐infected hamsters. DNA lesions were detected by double immunofluorescence and the hepatic expression of oxidant‐generating and antioxidant genes was assessed by quantitative RT‐PCR analysis. Dietary 1.0% curcumin significantly decreased OV‐induced accumulation of 8‐oxo‐7,8‐dihydro‐2′‐deoxyguanosine (8‐oxodG), an oxidative DNA lesion, and 8‐nitroguanine, a nitrative DNA lesion, in the nucleus of bile duct epithelial and inflammatory cells. Expression of oxidant‐generating genes (inducible nitric oxide synthase; iNOS, its nuclear transcriptional factor, NF‐κB, and cyclooxygenase‐2), and plasma levels of nitrate, malondialdehyde, and alanine aminotransferase, were also decreased in curcumin‐treated group. In contrast, curcumin increased the mRNA expression of antioxidant enzymes (Mn‐superoxide dismutase and catalase), and ferric‐reducing anti‐oxidant power in the plasma. In conclusion, curcumin reduced oxidative and nitrative DNA damage by suppression of oxidant‐generating genes and enhancement of antioxidant genes, leading to inhibition of oxidative and nitrative stress. Therefore, curcumin may be used as a chemopreventive agent to reduce the severity of OV–associated diseases and the risk of cholangiocarcinoma (CCA).