bluuebunny/crossref_metadata_2025_split huggingface dataset:
Outcomes of static and dynamic facial nerve repair in head and neck cancer
Authors: Iseli Tim A. , Harris Gregory , Dean Nichole R. , Iseli Claire E. , Rosenthal Eben L. 
Published: February 2010

AbstractObjectives/Hypothesis:Determine outcomes associated with nerve grafting versus static repair following facial nerve resection.Study Design:Retrospective chart review.Methods:Charts from 105 patients who underwent facial nerve reconstruction between January 1999 and January 2009 were reviewed. The majority had parotid malignancy (78.1%), most commonly squamous cell carcinoma (50.5%). Patients underwent static (n = 72) or dynamic (n = 33) reconstruction with nerve grafting. Facial nerve function was measured using the House‐Brackmann (H‐B) scale.Results:Patients receiving static reconstruction were on average 10.3 years older (P = .002). Mean overall survival for tumor cases was 61.9 months; parotid squamous cell carcinoma was associated with worse prognosis (P = .10). Median follow‐up was 16.1 months (range, 4–96.1 months). Most (97%) patients receiving a nerve graft had some return of function at a median of 6.2 months postoperatively (range, 4–9 months) and the majority (63.6%) had good function (H‐B score ≤4). Patients having static reconstruction (29.2%) were more likely to have symptomatic facial palsy than those having a nerve graft (15.2%, P = .12).Conclusions:Where possible, nerve grafting is the preferred method of facial nerve reconstruction. Although elderly patients with parotid malignancy have traditionally been considered poor candidates for nerve grafting, we demonstrate good results within 9 months of facial nerve repair even with radiotherapy, the use of long grafts (>6 cm), and prolonged preoperative dysfunction. Laryngoscope, 2010
Characterization of mesenchymal stem cells from human vocal fold fibroblasts
Authors: Hanson Summer E. , Kim Jaehyup , Johnson Beatriz H. Quinchia , Bradley Bridget , Breunig Melissa J. , Hematti Peiman , Thibeault Susan L. 
Published: February 2010

AbstractObjectives/Hypothesis:Mesenchymal stem cells (MSCs) originally isolated from bone marrow (BM), are fibroblast‐looking cells that are now assumed to be present in the stromal component of many tissues. MSCs are characterized by a certain set of criteria, including their growth culture characteristics, a combination of cell surface markers, and the ability to differentiate along multiple mesenchymal tissue lineages. We hypothesized that human vocal fold fibroblasts (hVFF) isolated from the lamina propria meet the criteria established to define MSCs and are functionally similar to MSCs derived from BM and adipose tissue.Study Design:In vitro study.Methods:hVFF were previously derived from human vocal fold tissues. MSCs were derived from adipose tissue (AT), and BM of healthy donors based on their attachment to culture dishes and their morphology and expanded in culture. Cells were analyzed for standard cell surface markers identified on BM‐derived MSCs and the ability to differentiate into cells of mesenchymal lineage (i.e., fat, bone, and cartilage). We investigated the immunophenotype of these cells before and after interferon‐γ (INF‐γ) stimulation.Results:hVFF displayed cell surface markers and multipotent differentiation capacity characteristic of MSCs. Furthermore, these cells exhibited similar patterns of expression of human leukocyte antigen and costimulatory molecules, after stimulation with INF‐γ compared to MSCs derived from BM and AT.Conclusions:Based on our findings, hVFF derived from lamina propria have the same cell surface markers, immunophenotypic characteristics, and differentiation potential as BM‐ and AT‐derived MSCs. We propose that vocal fold fibroblasts are MSCs resident in the vocal fold lamina propria. Laryngoscope, 2010
Tonsillectomy in post‐transplant lymphoproliferative disease in children
Authors: Sturm‐O'Brien Angela K. , Hicks M. John , Giannoni Carla M. , Sulek Marcelle , Friedman Ellen M. 
Published: February 2010

AbstractObjectives/Hypothesis:To review the role of tonsillectomy in diagnosis and management of post‐transplant lymphoproliferative disorder (PTLD).Study Design:Case series using a retrospective chart review.Methods:A retrospective review of post‐transplant lymphoproliferative disease at a tertiary academic medical center from January 2004 to April 2008. Data extracted includes patients' gender, age at transplantation, year of transplantation and tonsillectomy, type of transplant, presenting symptoms, type of immunosuppression, and outcome.Results:Six out of 25 (24%) patients who underwent tonsillectomy were found to have PTLD. The patient's characteristics, gender, age at transplantation, year of transplantation and tonsillectomy, type of transplant, presenting symptoms, type of immunosuppression, and outcomes are discussed.Conclusions:In our series, tonsillar hypertrophy, male gender, young age at transplantation, and liver transplantation were associated with higher rates of PTLD. Given the devastating nature of PTLD, early detection with tonsillectomy and institution of treatment is critical. Laryngoscope, 2010
Bone‐anchored hearing aid subjective benefit for unilateral deafness
Authors: House John W. , Kutz Joe Walter , Chung Janice , Fisher Laurel M. 
Published: February 2010

AbstractObjectives/Hypothesis:Determine the benefit of the bone‐anchored hearing aid (BAHA) in patients with unilateral deafness.Study Design:Retrospective case series and prospective questionnaire study at a tertiary referral center.Methods:Patients with unilateral deafness of various etiologies who were implanted with a BAHA (n = 126) or not implanted with a BAHA after a translabyrinthine craniotomy (n = 126) were mailed questionnaires. A total of 139 patients (55%) responded to the questionnaires. Patients who were implanted with a BAHA received a general questionnaire concerning BAHA usage, the Abbreviated Profile of Hearing Aid Benefit (APHAB), and the Speech, Spatial, and Qualities of Hearing Questionnaire (SSQ). Patients not implanted with a BAHA received only the SSQ hearing questionnaire.Results:Patients with unilateral deafness demonstrated a benefit with BAHA use on the APHAB. Most improvement with the BAHA was seen in the Background Noise subscale, with a 17.4% improvement. Ease of Communication and Reverberation subscales also demonstrated an 11.6% and 13.2% benefit, respectively. Patients with a BAHA demonstrated better scores in the SSQ Speech subscale when compared to unilaterally deaf patients who did not have a BAHA, although this difference was not significant.Conclusions:The APHAB demonstrated significant benefit with the use of a BAHA in patients with unilateral deafness. Although the SSQ speech subscale showed overall improvement in auditory disability with the use of a BAHA, this difference was not significant. However, the SSQ hearing questionnaire demonstrated specific situations were the BAHA is most useful. Laryngoscope, 2010
Molecular Structure Modulated Organization and Properties of Azobenzene‐Substituted Polydiacetylene Assemblies Films: Photopolymerization, Morphology, and Thermal Stability
Authors: Wang Yali , Chen Xin , Zou Gang , Zhang Qijin 
Published: February 2010

AbstractThree accessible azobenzene mesogen‐substituted diacetylene monomers (DA1, DA2, and DA3) were synthesized and the effect of the molecular structure on the photopolymerization behavior and self‐assembled structures of the resulting azobenzene‐substituted polydiacetylene (PDA) films had been investigated in detail. The films derived from DA1 were substantially polymerized into blue phase. However, the films derived from DA2 and DA3 were polymerized into red phase directly. The morphology, packing structure, and thermal stability of the resulting azobenzene‐substituted PDA films were characterized in detail by SEM, XRD as well as POM measurements. PDA1 formed micrometer‐sized lamellar crystal structures, while PDA2 and PDA3 both formed spherulitic crystal structures. The strong π–π stacking interaction among side chains was essential for maintaining high stability upon thermal stimulus.magnified image
Substituent Effects on RAFT Polymerization with Benzyl Aryl Trithiocarbonates
Authors: Bicciocchi Erika , Chong Yen K. , Giorgini Loris , Moad Graeme , Rizzardo Ezio , Thang San H. 
Published: February 2010

AbstractThe RAFT polymerization of styrene in the presence of benzyl aryl trithiocarbonate RAFT agents (Z′SC(=S)SR) has been studied. The values of the apparent transfer constants of the benzyl aryl trithiocarbonates (0.029 M) in bulk styrene polymerization at 110 °C fall within the range 10–25 depending on substituents on the aryl ring (Z′) and are higher than that of benzyl dodecyl trithiocarbonate 1 for which was determined to be 9.4. There is a trend for higher transfer constant, lower dispersity product and better control over polymerization with more electron‐withdrawing substituents with the most active in the series studied being the 3,5‐bis(trifluoromethyl)phenyl derivative.magnified image
Hydroxyl‐Functionalized Norbornene Based Co‐ and Terpolymers by Scandium Half‐Sandwich Catalyst
Authors: Tritto Incoronata , Ravasio Andrea , Boggioni Laura , Bertini Fabio , Hitzbleck Julia , Okuda Jun 
Published: February 2010

AbstractCopolymerization of ethylene with 5‐norbornene‐2‐methanol and terpolymerization of ethylene with norbornene and 5‐norbornene‐2‐methanol by a rare‐earth metal based catalyst, specifically the half‐sandwich bis(alkyl) scandium precursor [Sc(η5‐C5Me4SiMe3)(η1‐CH2SiMe3)2(THF)] activated by [Ph3C][B(C6F5)4] were successfully achieved for the first time. A protocol for masking of OH functionality by AliBu3 to avoid catalyst poisoning was exploited. Copolymers with high molar masses and noticeable incorporation of functionalized norbornene derivative were obtained. Terpolymers with very high molar masses and with a broad range of composition were prepared with excellent yields.magnified image
The Development and Characterization of Starch Microspheres Prepared by a Sonochemical Method for the Potential Drug Delivery of Insulin
Authors: Grinberg Olga , Gedanken Aharon 
Published: February 2010

AbstractThis study deals with the production of starch microspheres containing insulin using the sonochemical technique. The structure and properties of the final product were studied using SEM, FTIR and XRD. A microsphere size of 600 nm and the size distribution of the starch microspheres with encapsulated insulin were determined. A spectrophotometric analytical procedure was selected to evaluate the amount of loaded insulin in the starch microspheres and to perform the release studies. The product is organized in a double‐layer structure (insulin layer covered by starch layer), and this composite may provide a new system for the administration of protein drugs. The microspherilization process involves the degradation of the starch to the smaller fragments due to the application of high‐intensity ultrasound, and the organization of these fragments in a microsphere structure using the same type of bonds as in regular starch.magnified image
Colloid‐Assisted Self‐Assembly of Robust, Three‐Dimensional Networks of Carbon Nanotubes over Large Areas
Authors: Jurewicz Izabela , King Alice A. K. , Worajittiphon Patnarin , Asanithi Piyapong , Brunner Eric W. , Sear Richard P. , Hosea Thomas J. C. , Keddie Joseph L. , Dalton Alan B. 
Published: February 2010

AbstractNatural materials, such as bone and spider silk, possess remarkable properties as a result of sophisticated nanoscale structuring. They have inspired the design of synthetic materials whose structure at the nanoscale is carefully engineered or where nanoparticles, such as rods or wires, are self‐assembled. Although much work has been done in recent years to create ordered structures using diblock copolymers and template‐assisted assembly, no reports describe highly ordered, three‐dimensional nanotube arrays within a polymeric material. There are only reports of two‐dimensional network structures and structures on micrometer‐size scales. Here, we describe an approach that uses plasticized colloidal particles as a template for the self‐assembly of carbon nanotubes (CNTs) into ordered, three‐dimensional networks. The nanocomposites can be strained by over 200% and still retain high conductivity when relaxed. The method is potentially general and so may find applications in areas such as sensing, photonics, and functional composites.magnified image
Preparation of Clickable Poly(3‐hydroxyalkanoate) (PHA): Application to Poly(ethylene glycol) (PEG) Graft Copolymers Synthesis
Authors: Babinot Julien , Renard Estelle , Langlois Valérie 
Published: February 2010

AbstractA new synthesis of amphiphilic biodegradable copolymers consisting of hydrophobic poly(3‐hydroxyalkanoate) (PHA) backbone and hydrophilic poly(ethylene glycol) (PEG) units as side chains is described. Poly[(3‐hydroxyoctanoate)‐co‐(3‐hydroxyundecenoate)] (PHOU) was first methanolyzed and its unsaturated side chains were quantitatively oxidized to carboxylic acid. Esterification with propargyl alcohol led to an alkyne‐containing “clickable” PHA in 71% conversion. Its reactivity was successfully demonstrated by grafting azide‐terminated PEG chains of 550 and 5 000 g · mol−1, respectively. All products were fully characterized using GPC, 1H, and COSY NMR.magnified image
Prevalence and cost of medication nonadherence in Parkinson's disease: Evidence from administrative claims data
Authors: Davis Keith L. , Edin Heather M. , Allen Jeffery K. 
Published: February 2010

AbstractWe estimated the prevalence of medication nonadherence in Parkinson's disease (PD) and the association between treatment nonadherence and healthcare costs. Insurance claims from over 30 US health plans were analyzed. Inclusion criteria were as follows: PD diagnosis, ≥1 PD‐related prescription between 1/1/1997 and 12/31/2004, continuous health plan enrollment for ≥6 months before and ≥12 months after first PD prescription. Adherence, all‐cause healthcare utilization, and all‐cause costs were evaluated over 12 months post‐treatment initiation. Adherence was measured using the medication possession ratio (MPR), with MPR < 0.8 defining nonadherence. Among patients identified for inclusion (N = 3,119), 58% were male and mean age was 69 years. Mean MPR was 0.58 and 61% of patients were nonadherent. Unadjusted mean medical costs were significantly higher (P < 0.01) among nonadherers ($15,826) compared with adherers ($9,228), although nonadherers had lower prescription drug costs ($2,684 vs. $3,854; P < 0.05). After controlling for confounders in multivariable analyses, a large positive relationship between nonadherence and both medical and total healthcare costs remained (+$3,451, P < 0.0001 and +$2,383, P = 0.0053, respectively). Medication adherence in PD is suboptimal and nonadherence may be associated with increased healthcare costs despite offsets from reduced drug intake. Efforts to promote medication adherence in PD may lead to cost savings for managed care systems. © 2010 Movement Disorder Society
Descriptions of Cervical Dystonia by Sir Charles Bell
Authors: Gonzalez‐Alegre Pedro 
Published: February 2010

AbstractSir Charles Bell is better known among neurologists for his descriptions of the clinical consequences of facial nerve lesions. However, as an accomplished physician, anatomist, and artist, he made many other contributions to the fields of neurology and neuroscience. Among those, his descriptions of patients with what we now know as cervical dystonia have not received much attention. In this report, Bell's depictions of patients presenting with a syndrome consistent with cervical dystonia will be discussed, including the identification of many of the different clinical features we currently use for the diagnosis of this disorder and his thoughts about its pathogenesis. © 2010 Movement Disorder Society
Four‐week trunk‐specific rehabilitation treatment improves lateral trunk flexion in Parkinson's disease
Authors: Bartolo Michelangelo , Serrao Mariano , Tassorelli Cristina , Don Romildo , Ranavolo Alberto , Draicchio Francesco , Pacchetti Claudio , Buscone Simona , Perrotta Armando , Furnari Anna , Bramanti Placido , Padua Luca , Pierelli Francesco , Sandrini Giorgio 
Published: February 2010

AbstractPeople with Parkinson's disease (PD) often have a posture characterized by lateral trunk flexion poorly responsive to antiparkinsonian drugs. To examine the effects of a rehabilitation programme (daily individual 90‐minute‐sessions, 5‐days‐a‐week for 4‐consecutive weeks) on lateral trunk flexion and mobility, 22 PD patients with mild to severe lateral trunk flexion, and 22 PD patients without trunk flexion were studied. Patients were evaluated using the Unified Parkinson's Disease Rating Scale motor subscale (UPDRS‐III) score, and the kinematic behavior of the trunk was recorded by means of an optoelectronic system to determine: a) trunk flexion, inclination and rotation values in the erect standing posture; b) ranges of trunk flexion and inclination during trunk movements. After the treatment, significant decreases in trunk flexion [24°(4) vs. 14°(3), P < 0.001] and inclination in the static condition [23°(5) vs. 12°(4), P < 0.001)] were observed, both of which were maintained at the 6‐month follow up. During the trunk flexion task, a significantly increased range of trunk flexion [64°(15) vs. 83°(15), P < 0.001] was observed; similarly, during the lateral bending task, the range of trunk inclination was found to be significantly increased, both toward the side of the trunk deviation [29°(8) vs. 42°(13), P < 0.01] and toward the contralateral side [14°(6) vs 29°(11), P < 0.01]. No further significant changes were observed at the 6‐month follow‐up. Trunk flexion and inclination values in the upright standing posture correlated slightly with the UPDRS‐III score. Our findings show that significant improvements in axial posture and trunk mobility can be obtained through the 4‐week rehabilitation programme described, with a parallel improvement in clinical status. © 2010 Movement Disorder Society
A case‐control study on restless legs syndrome in nondialyzed patients with chronic renal failure
Authors: Merlino Giovanni , Lorenzut Simone , Gigli Gian Luigi , Romano Giulio , Montanaro Domenico , Moro Alessandro , Valente Mariarosaria 
Published: February 2010

AbstractRestless legs syndrome (RLS) is a possible consequence of end‐stage renal disease. However, conclusive data on the association between RLS and chronic renal failure (CRF) in nondialyzed patients are still lacking. The aims of this study were: (1) to look for an association between RLS and CRF in nondialyzed patients; (2) to analyze the characteristics of RLS and its consequences on nocturnal rest in nondialyzed patients with CRF; (3) to identify possible predictors of RLS occurrence in nondialyzed patients with CRF. We recruited 138 nondialyzed patients with CRF (mean age: 69.8 ± 11.7 years; male: 61.6%) and 151 controls (mean age: 60.2 ± 18.6 years; male: 42.4%). An expert in sleep medicine investigated the presence of RLS by means of a face‐to‐face interview. Fifteen nondialyzed CRF patients and five controls were diagnosed as RLS affected. A multivariate analysis confirmed that RLS was independently associated with CRF in nondialyzed patients (P = 0.004). CRF patients RLS+ were more commonly women and showed the presence of an iron deficiency compared with the RLS− ones. Independent predictors of RLS in nondialyzed CRF patients were: female sex (OR: 10.7, 95% CI: 2.2–31.3; P = 0.004) and percentage of transferrin saturation (OR: 0.6, 95% CI: 0.4–0.9; P = 0.04). This is the first case‐control study able to recognize an association between RLS and CRF in patients not yet on dialysis. Nephrologists should investigate and treat RLS in their nondialyzed patients with CRF. In particular, physicians should carefully investigate women and patients with iron deficiency in the presence of RLS symptoms. © 2010 Movement Disorder Society
Distinguishing SWEDDs patients with asymmetric resting tremor from Parkinson's disease: A clinical and electrophysiological study
Authors: Schwingenschuh Petra , Ruge Diane , Edwards Mark J. , Terranova Carmen , Katschnig Petra , Carrillo Fatima , Silveira‐Moriyama Laura , Schneider Susanne A , Kägi Georg , Palomar Francisco J , Talelli Penelope , Dickson John , Lees Andrew J. , Quinn Niall , Mir Pablo , Rothwell John C. , Bhatia Kailash P. 
Published: February 2010

AbstractApproximately 10% of patients diagnosed clinically with early Parkinson's disease (PD) have normal dopaminergic functional imaging (Scans Without Evidence of Dopaminergic Deficit [SWEDDs]). An important subgroup of SWEDDs are those with asymmetric rest tremor resembling parkinsonian tremor. Clinical and pathophysiological features which could help to distinguish SWEDDs from PD have not been explored. We therefore studied clinical details including non‐motor symptoms in 25 tremulous SWEDDs patients in comparison to 25 tremor‐dominant PD patients. Blinded video rating was used to compare examination findings. Electrophysiological tremor parameters and also response to a cortical plasticity protocol using paired associative stimulation (PAS) was studied in 9 patients with SWEDDs, 9 with tremor‐dominant PD (with abnormal dopamine transporter single photon emission computed tomography findings), 8 with segmental dystonia, and 8 with essential tremor (ET). Despite clinical overlap, lack of true bradykinesia, presence of dystonia, and head tremor favored a diagnosis of SWEDDs, whereas re‐emergent tremor, true fatiguing or decrement, good response to dopaminergic drugs, and presence of non‐motor symptoms favored PD. A single tremor parameter could not differentiate between groups, but the combination of re‐emergent tremor and highest tremor amplitude at rest was characteristic of PD tremor. SWEDDs and segmental dystonia patients exhibited an abnormal exaggerated response to the PAS protocol, in contrast to a subnormal response in PD and a normal response in ET. We conclude that despite clinical overlap, there are features that can help to distinguish between PD and SWEDDs which may be useful in clinical practice. The underlying pathophysiology of SWEDDs differs from PD but has similarities with primary dystonia. © 2010 Movement Disorder Society