bluuebunny/crossref_metadata_2025_split huggingface dataset:
Phyllanthus niruni (Meniran) Aqueous and Ethanol Extracts Promotes Adipogenic Differentiation in 3T3-L1 Preadipocytes
Authors: Purnamasari Listya , Flores dela Cruz Joseph , Khasanah Himmatul , Gu Hwang Seong , Nam In Sik , Koo Yi Jun 
Published: June 2024

Abstract
Consumers determine intramuscular fat as one of the important factors for the quality and palatability of beef meat. In a recent study, Phyllanthus niruri (meniran) has practical uses for feed additives and was screened for their ability to improve preadipocyte proliferation and differentiation. This study evaluates the effect of meniran aqueous and ethanol extracts on promoting adipogenic differentiation in 3T3-L1 preadipocytes and were investigated via CCK-8 assay, Oil red O-Staining, and RT-PCR analysis. For differentiation to adipocytes, post-confluent 3T3-L1 preadipocytes were stimulated DMEM containing 10% FBS, 5 μg/ml insulin, 0.5mM 3-isobutyl-1-methylxanthine, and 1 μM dexamethasone. 3T3-L1 were cultured with meniran aqueous and ethanol extract (25, 50, 100, and 200 ppm). Intracellular lipid accumulation was significantly increased by meniran extract until 100 ppm and decreased at 200 ppm. The expressions of adipocyte differentiation on mRNA transcription factors PPARγ and C/EBPꭤ were stimulated by 25-100 ppm of meniran both aqueous and ethanol extract but lower at 200 ppm. In the future, these findings may be applied to develop feed additives from natural plant extracts which may be used to increase intramuscular fat accumulation in beef cattle through manipulation of adipocyte differentiation.
Co-existence of mycotoxins in the diet of layer farms in Java Provinces of Indonesia
Authors: Sumantri I , Hidayat A A A , Kusumawardhani E 
Published: June 2024

Abstract
Mycotoxins adversely affect animal health and production. The presence of multiple mycotoxins may exert greater toxicity than exposure to a single mycotoxin. However, data on the co-occurrence of mycotoxins in animal feed is scarce, especially from Indonesia. This study was conducted to investigate the co-occurrence of the major mycotoxins, namely aflatoxin B1, fumonisin, ochratoxin A, zearalenone and T-2 toxin. A total of 146 samples were collected from layer farms in the provinces of West Java, Central Java and East Java. Mycotoxins were determined by ELISA test using commercial ELISA kits for each mycotoxin. The results showed that there are 96% samples contaminated by multiple mycotoxins, which consisted of 51% samples containing 5 mycotoxins, 28% samples containing 4 mycotoxins, 11% samples containing 3 mycotoxins. and 5% samples containing 2 mycotoxins. This survey also showed that fumonisins is the most common mycotoxin in layer diets, found in 100% of the samples, followed by zearalenone (94%), aflatoxin B1 (88%), ochratoxin (73%) and T-2 (68%). It is concluded that the very high co-occurrence of mycotoxin contamination found in layer diets from Java provinces represents a significant risk to animal health and production due to their potential toxic interactions.
Local Community Participation Under Proboscis Monkey Conservation-Based Ecotourism Development in Curiak Island Area
Authors: Hafizh Zuhdi Muhammad , Satya Mastuti Widi Tri , Rezeki Amalia , Romadhoni Surya Putra Ahmad 
Published: June 2024

Abstract
This study was conducted to identify local participation under proboscis monkey conservation-based ecotourism development in Curiak Island Area and the relationship between their socio-demographic characteristics. A total of 20 respondents participated in the study. The data taken included respondents’ profiles and local community participation in proboscis monkey ecotourism development. The data were analyzed by using descriptive statistics analysis and rank Spearman correlation analysis. The results showed that local community participation in proboscis monkey conservation-based ecotourism is at a medium level with an average mean score of 3.34. The correlation coefficient between age and local community participation is −0.223 with a significance value of 0.345 so that it can be said that there is no significant relationship (p>0.05) between age and local community participation and are at a very low category, the correlation coefficient value between gender and local community participation is 0.286 with a significance value of 0.221 so that it can be said that there is no significant relationship (p>0.05) between gender and community participation local and are at a low category, the correlation coefficient value between education and local community participation is 0.296 with a significance value of 0.205 so that it can be said that there is no significant relationship (p>0.05) between education and local community participation and are at a low category, and the correlation coefficient value between income and local community participation is 0.496 with a significance value of 0.026 so that it can be said that there is a real relationship (p<0.05) between income and local community participation and are at a medium category. It can be concluded that local community participation in proboscis monkey conservation-based ecotourism is at a medium level. The socio-demographic characteristic that has a real relationship with local community participation is monthly income. Socio-demographic characteristics that have no significant relationship with local community participation are age, education, and educational background.
Relationship between parturition and body condition score on estrus expression of tropical Saanen Crossbred does
Authors: Diatmono D F F , Padmawati F G , Magistrama M E , Kumala S , Sitaresmi P I , Widyobroto B P , Widayati D T 
Published: June 2024

Abstract
Saanen Crossbred goats are an excellent livestock commodity with great potential for development in Indonesia. This excellent potential is not optimal due to the limitations of farmers in detecting estrus for mating program. This study aimed to determine the relationship between body condition score (BCS) and parturition on the characteristics of estrus. This study included 18 non-pregnant Saanen Crossbred does aged 3 years. Does were grouped based on parturition number (1 and 2) and BCS (2.5 and 3). The variables measured including vulva color, swelling, mucus secretion, vaginal pH, vaginal temperature, and salivary ferning. Data were analysed using independent sample T-Test and correlation analysis. The results showed that does with parturition 2 (2.16±0.40) had higher swelling parameter values (p<0.01) than parturition 1 (1.16±0.38), and does with BCS 3 (2.11±0.33) had higher color parameter values (p<0.01) than dose with BCS 2.5 (1.33±0.50). Additionally, the results indicated a positive correlation for several estrus characteristics, including color with swelling (0.58), color with mucus (0.531), and pH with ferning (0.501). It has also been found that the ferning method may be an easier estrus detection tool. Based on these findings, both parturition and BCS affect some estrus expressions, and several estrus characteristics are correlated.
Electrodeposition of Zn/TiO2 coatings on Ti6Al4V produced by selective laser melting, the characterization and corrosion resistance
Authors: Gündüz Demet Özaydın , Küçüktürk Gökhan , Pul Muharrem , Salunkhe Sachin , Kaya Duran , Kabalcı Mehmet , Čep Robert , Abouel Nasr Emad 
Published: June 2024

Abstract
Recently, additive manufacturing techniques have begun to be implemented extensively in the production of implants. Ti6Al4V alloy is a material of choice for implants due to its low density and high biocompatibility. Recent research, however, has demonstrated that Ti6Al4V alloy emits long-term ions (such as Al and V) that are hazardous to health. Surface modifications, including coating, are therefore required for implants. The electrodeposition method was utilized to deposit Zn-doped TiO2 onto the surfaces of Ti6Al4V samples, which were manufactured via the selective laser melting method. The effects of processing time, amount of TiO2 addition, microstructure of anode materials, and resistance to wear and corrosion were investigated. The coating hardness and thickness increased with increasing processing time and TiO2 concentration. It has been observed that the addition of TiO2 to zinc anode coatings results in an increase in wear and a decrease in corrosion rate. It was noted that the specimens exhibiting the most significant wear also possessed the highest hardness value. The specimens were generated utilizing a graphite anode, underwent a 30-min processing time, and comprised 10 g l−1 of TiO2.
Enhanced photoluminescence and structural properties of Zn-doped anatase TiO2 nanoparticles
Authors: Yihunie Moges Tsega 
Published: June 2024

Abstract
Undoped and zinc-doped TiO2 nanoparticles (NPs) were synthesized by the sol–gel method. The XRD spectra revealed that both synthesized undoped and Zn-doped TiO2 NPs remain in the anatase phase after calcined at 500 °C. The crystallite size was increased from 17 to 52 nm as the Zn content was increased from 0 to 0.2 mol%, which implies also a decrease of the micro-strain and surface area. The agglomerated spherical-like morphology with a diameter of roughly 10–20 nm was shown by SEM and TEM micrographs. The bandgap values were found to be decreased from 3.2 to 3.0 eV when Zn concentration increased from 0 to 0.2 mol%. A reduction in bandgap with an increase in dopant concentration may due to the increased in crystallite size along with enhanced lattice parameters (i.e., a and c) and d-spacing. From PL spectra, all samples exhibited a broad emission band in the visible region of about 400–500 nm centered at 430 nm. The highest PL emission was obtained for 0.2 mol% Zn doping. The broad PL emission over the visible range is greatly reduced at 0.4 mol% Zn due to concentration quenching. It is suggested that the Zn2+ doping induced oxygen vacancies which could promote the photoluminescence processes.
Study on notch tensile properties of Fe-Mn-Si shape memory alloy
Authors: Niu Haojie , Sun Yubin , Lin Chengxin 
Published: June 2024

Abstract
In order to investigate the effect of stress concentration on the mechanical properties of Fe-Mn-Si shape memory alloy, Fe17Mn5Si10Cr5Ni shape memory alloy was selected as the research object in this study. Specimens with different notch types and sizes were designed, and uniaxial tensile tests were conducted on the notched specimens at room temperature. The effects of notch parameters on stress–strain curve, the notch tensile strength, notch sensitivity, and fracture mode were studied. The results indicate that Fe-Mn-Si shape memory alloy is sensitive to notches. V-shaped notch specimens with the same notch radius exhibit stronger ductility and larger fracture strain than U-shaped notch specimens. The tensile strength of the notch increases with the decrease of the notch radius. The stress concentration caused by the notch limits the plastic deformation ability of the material, resulting in significantly lower ductility of the notched specimen compared to the smooth specimen. The presence of notches does not change the tensile fracture type of the alloy, which is ductile fracture. Compared with Q235 steel, Fe-Mn-Si shape memory alloy has better ductility. The stress–strain curve of Q235 steel shows a clear yield plateau and slight hardening behavior, while the yield plateau of Fe-Mn-Si shape memory alloy is not obvious.
Inkjet-printed low temperature co-fired ceramics: process development for customized LTCC
Authors: Jäger Jonas , Ihle Martin , Gläser Kerstin , Zimmermann André 
Published: June 2024

Abstract
This paper investigates the utilization of digital printing technologies for the fabrication of low temperature co-fired ceramics (LTCC). LTCC offer great opportunities for applications such as antennas, sensors or actuators due to their outstanding properties like low dielectric loss, low permittivity, low coefficient of thermal expansion and at the same time high reliability in harsh environments (heat, humidity, and radiation). LTCC are multilayer circuits that are typically functionalized by screen-printing. This publication investigates the replacement of screen-printing by digital printing processes, such as inkjet and Aerosol Jet printing, to facilitate a more resource-friendly and customizable manufacturing of LTCC. The use of digital printing technologies not only streamlines small-scale productions and development processes but also offers the advantage of achieving miniaturization down to single-digit microns. In this publication, digital printing processes, filling of vias, lamination processes, co-firing at 850 °C and printing on fired LTCC were investigated. Three layers of nanoparticle silver ink were printed on green LTCC tape and 100% of the embedded printed structures were conductive after co-firing. Filling of vias with inkjet printing was investigated and the most important process parameters were found to be the clustering of vias, the amount of active nozzles and the substrate temperature. Printing on fired LTCC demonstrated high precision, and sintering at 600 °C achieved strong adhesion of printed structures to LTCC. These successful findings culminate in presenting a process chain for fully maskless structured, multilayer LTCC.
Severe COVID-19 in pregnant women: Analysis of placental features and perinatal outcomes
Authors: Farias Arcos Júnior Gelson , Pulcineli Vieira Francisco Rossana , Kill Beatriz , Verzinhasse Peres Stela , B. C. Gibelli Maria Augusta , Ibidi Silvia Maria , Brunow de Carvalho Werther , Braz Simões Angélica , Brizot Maria de Lourdes , Schultz Regina , Azevedo Carvalho Mariana ,   HC-FMUSP-Obstetric COVID-19 Study Group, Waissman Adriana Lippi , Bassi Aline Scalisse , de Souza Ana Claudia Rodrigues Lopes Amaral , Farche Ana Claudia Silva , Igai Ana Maria Kondo , Martins Carlos Eduardo do Nascimento , Paganoti Cristiane de Freitas , Domingues Danielle Rodrigues , Mikami Fernanda Cristina Ferreira , Baptista Fernanda Spadotto , Cippiciani Jacqueline Kobayashi , Albertini Jéssica Gorrão Lopes , de Andrade Joelma Queiroz , Niigaki Juliana Ikeda , Pereira Lucinda Cristina , Galletta Marco Aurélio Knippel , Miyadahira Mariana Yumi , Barbosa Mariana Vieira , de Barros Monica Fairbanks , Garavazzo Sckarlet Ernandes Biancolin , Martinelli Silvio , Arrym Tiago Pedromonico , Gomez Ursula Trovato , Franco Veridiana Freire 
Published: June 2024

Abstract

Objectives
Changes in placental features, such as maternal and fetal vascular malperfusion, are associated with SARS-CoV-2 infection. The anatomopathologic study of the placenta is crucial for understanding pregnancy and fetal complications. To that end, this study aimed to describe placental features and analyze the association between placental findings and perinatal outcomes in a cohort of pregnant women with severe COVID-19.

Methods
This nested study within a prospective cohort study consisted of 121 singleton pregnant women with a diagnosis of severe COVID-19. Placental pathologic findings were described, and the associations between severe COVID-19 and clinical parameters and perinatal outcomes were assessed.

Results
The prevalence of maternal vascular malperfusion was 52.1%, followed by fetal vascular malperfusion at 21.5%, ascending intrauterine infections at 11.6%, and inflammatory lesions at 11.6%. Other lesions were observed in 39.7% of the placentas examined. Inflammatory lesions were an independent factor (P = .042) in 5-minute Apgar scores below 7. Ascending infection was associated with fetal death (P = .027).

Conclusions
Maternal vascular malperfusion was the most prevalent placental feature in patients with severe COVID-19. Chorangiosis is associated with poor perinatal outcomes.
Evaluation of an electronic health record Drug Interaction Customization Editor (DICE)
Authors: Romero Andrew , Gomez-Lumbreras Ainhoa , Villa-Zapata Lorenzo , Tan Malinda , Horn John , Malone Daniel C 
Published: June 2024

Abstract

Purpose
Due to the low specificity of drug-drug interaction (DDI) warnings, hospitals and healthcare systems would benefit from the ability to customize alerts, thereby reducing the burden of alerts while simultaneously preventing harm. We developed a tool, called the Drug Interaction Customization Editor (DICE), as a prototype to identify features and functionality that could assist healthcare organizations in customizing DDI alerts.

Methods
A team of pharmacists, physicians, and DDI experts identified attributes expected to be useful for filtering DDI warnings. A survey was sent to pharmacists with informatics responsibilities and other medication safety committee members to obtain their opinions about the tool. The survey asked participants to evaluate the 4 sections of the DICE tool (General, Medication, Patient, and Visit) on a scale ranging from 0 (not useful) to 100 (very useful). The survey provided an opportunity for participants to express their opinions on the overall usefulness of the DICE tool and to provide other comments.

Results
The 50 survey respondents were mainly pharmacists (n = 47, 94%) with almost half (n = 23, 47%) having health information technology/informatics training. Most respondents (n = 33, 80%) were employed by organizations with over 350 beds. Respondents indicated the most useful features of the DICE tool were the ability to filter DDI warnings based on routes of administrations (mean [SD] rating scale score, 86.5 [21.6]), primary drug properties (85.7 [20.5]), patient attributes (85.6 [16.7]) and laboratory attributes (88.8 [18.0]). The overall impression of the DICE tool was rated at 82.8 (19.0), and when asked about the potential to reduce DDI alerts, respondents rated the tool at 83.7 (21.8).

Conclusion
The ability to customize DDI alerts using data elements currently within the electronic health records (EHRs) has the potential to decrease alert fatigue and override rates. This prototype DICE tool could be used by end users and vendors as a template for developing a more advanced DDI filtering tool within EHR systems.
The Social Aesthetics of Digital Diplomacy
Authors: Møller Anna Helene Kvist , Adler-Nissen Rebecca , Golovchenko Yevgeniy , Eggeling Kristin Anabel 
Published: June 2024

Abstract
This article presents a theory and analysis of the social aesthetics of digital diplomacy. Drawing inspiration from the sociology of taste and visual theory, we conceptualize social aesthetics as the encoding of social norms and hierarchies into visual representations. Through this lens, we examine how the multitude of images uploaded by diplomats on social media daily contribute to the symbolic authority of their profession, ritually conveying ideals of international mediation and sovereign equality. Using advancements in computer vision methods, we analyze over 55,000 images sourced from tweets by more than 1,000 ambassadors globally. In contrast to prevailing research highlighting how social media images disrupt traditional diplomatic norms, facilitate strategic nation-branding, or promote individuals, our large-scale analysis reveals a remarkable uniformity in these images across diplomats from different countries. We demonstrate how diplomatic images perpetuate a Western visual canon, thereby reinforcing structures of power and distinction, and delineating the normative boundaries of diplomacy as a global institution. The article contributes to debates about diplomacy, aesthetics, taste, rituals, and power in international relations. Furthermore, it underscores the value of computer vision and convolutional neural networks in uncovering large-scale social patterns and relationships within practices previously perceived as highly personalized or strategic.
The State of the Discipline: How Far Along Are We in Developing an IR Theory Based on Southeast Asia’s Experiences
Authors: na Thalang Chanintira , Chong Ja Ian , Do Thuy Thi , Kraft Herman Joseph S , Kuik Cheng-Chwee , Wicaksana I Gede Wahyu , Chheang Vannarith , Santoso Yohanes William , Benny Guido 
Published: June 2024

Abstract
Based on reflexive stocktaking and data collected from a cross-country survey distributed in seven Southeast Asian academic communities, namely Cambodia, Indonesia, Malaysia, Singapore, Thailand, the Philippines, and Vietnam, this article explores how much progress Southeast Asian international relations (IR) academic communities have made in advancing a theory or concept based on local experiences. It is argued that while mainstream IR remains dominant, debates since the early 2000s have introduced new concepts. At the same time, new theoretical proposals are rare due to the vast diversity in Southeast Asia and a general interest in producing policy- and empirical-oriented work. Nevertheless, there are opportunities for constructing a Southeast Asian theory based on the region’s distinct perspectives on international relations shaped by ASEAN norms and institutions and the complex interactions between politics at the domestic and international levels. Any new conceptual or theoretical framework must also provide useful implications beyond the region.
On the utility of using the All of Us Research Program as a resource to study military service members and veterans
Authors: Porter Ben 
Published: June 2024

Abstract

Objectives
To illustrate the utility of the All of Us Research Program for studying military and veteran health.

Materials and Methods
Results were derived from the All of Us Researcher Workbench Controlled Tier v7. Specific variables examined were family history of post-traumatic stress disorder (PTSD), medical encounters, and body mass index/body size.

Results
There are 37 363 military and veteran participants enrolled in the All of Us Research Program. The population is older (M = 63.3 years), White (71.3%), and male (83.2%), consistent with military and veteran populations. Participants reported a high prevalence of PTSD (13.4%), obesity (40.2%), and abdominal obesity (77.1%).

Discussion and Conclusion
The breadth and depth of health data from service members and veterans enrolled in the All of Us Research Program allow researchers to address pressing health questions in these populations. Future enrollment and data releases will make this an increasingly powerful and useful study for understanding military and veteran health.
The Role of Quota Systems in Realising Planetary Boundaries
Authors: Dupont Valérie , Largey Thierry , Nahrath Stéphane , Weyermann Céline 
Published: June 2024

Abstract
A strong vision of sustainable development requires respect for the limits imposed by the functioning of the planet to ensure its resilience. The framework of planetary boundaries is increasingly relied on to design quantifiable objectives that can guide policy- and decisionmakers to enact measures to ensure such a sustainable society. Yet, to effectively guide, the framework requires a reformulation to make it applicable to human activities. Concretely, planetary boundaries need to be transposed into planetary quotas, which express the maximum absolute quantity of emissions, withdrawals or use that is admissible so as not to exceed the planetary limits. Furthermore, the achievement of planetary quotas depends on the fair allocation of national, sectoral, or even individual quotas. In this context, we question whether and under which institutional conditions environmental quotas could be an appropriate tool to implement planetary boundaries. This article proposes a legal and political theory of quota systems and applies it to the establishment of planetary quota systems in international environmental law.