bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparison of outcomes after allogeneic hematopoietic stem cell transplantation in patients with follicular lymphoma, diffuse large B‐cell lymphoma associated with follicular lymphoma, or de novo diffuse large B‐cell lymphoma
Authors: Tada Kohei , Kim Sung‐Won , Asakura Yoshitaka , Hiramoto Nobuhiro , Yakushijin Kimikazu , Kurosawa Saiko , Tajima Kinuko , Mori Shin‐ichiro , Heike Yuji , Tanosaki Ryuji , Maeshima Akiko Miyagi , Taniguchi Hirokazu , Furuta Koh , Kagami Yoshikazu , Matsuno Yoshihiro , Tobinai Kensei , Takaue Yoichi , Fukuda Takahiro 
Published: April 2012

AbstractThe outcome after allogeneic hematopoietic stem cell transplantation (allo‐HCT) for diffuse large B‐cell lymphoma (DLBCL) associated with follicular lymphoma (FL), which includes DLBCL with pre‐ or co‐existing FL, remains controversial, and few previous reports have compared the outcomes after allo‐HCT for FL, DLBCL associated with FL, and de novo DLBCL. We retrospectively analyzed 97 consecutive patients with FL (n = 46), DLBCL associated with FL (n = 22), or de novo DLBCL (n = 29) who received allo‐HCT at our institute between 2000 and 2010. With a median follow‐up of 53 months, the 5‐year overall survival (OS) and progression‐free survival (PFS) were, respectively, 77% and 70% for FL, 62% and 57% for DLBCL associated with FL, and 26% and 23% for de novo DLBCL. The 5‐year cumulative incidences of non‐relapse mortality and disease progression/relapse were, respectively, 16% and 15% for FL, 19% and 24% for DLBCL associated with FL, and 36% and 41% for de novo DLBCL. By a multivariate analysis, the OS and PFS for DLBCL associated with FL were significantly better than those for de novo DLBCL, whereas they were not significantly different from those for FL. These results suggest that allo‐HCT may be a promising option for patients with not only advanced FL but also DLBCL associated with FL. Am. J. Hematol. 2012. © 2012 Wiley Periodicals, Inc.
Energetic Payoff of Tool Use for Capuchin Monkeys in the Caatinga: Variation by Season and Habitat Type
Authors: EMIDIO RICARDO ALMEIDA , FERREIRA RENATA GONÇALVES 
Published: April 2012

AbstractIn this paper, we analyze predictions from the energetic bottleneck and opportunity models to explain the use of stones to crack open encased fruit by capuchins in dry environments. The energetic bottleneck model argues that tool use derives from the need to crack open hard‐encased fruits which are key resources during periods of food scarcity. The opportunity model argues that tool use by capuchins derives from simultaneous access to stones and encased fruits. The study was conducted in the Caatinga biome, northeastern Brazil, at two areas where capuchin monkeys (Sapajus libidinosus and Sapajus spp.) regularly use stones to crack open encased fruit of Syagrus cearensis and Manihot dichotoma. Energetic gains were inferred based on the number of tool‐use sites used and the mass of encased fruit consumed per month, and compared across seasons and areas occupied by the two groups. For the drier habitat, a significant increase in frequency of tool use (Ndry = 329 vs. Nwet = 59) and in the mean monthly mass of fruits consumed in the dry season (meandry = 193g vs. meanwet = 13.5 g) offered support for the energetic bottleneck model. However, our inference of low energetic payoffs for tool using individuals (in the drier caatinga habitat from 13 to 193 cal·ind−1·month−1 and in the wetter caatinga habitat from 805 to 1150 cal·ind−1·month−1) offer support for the opportunity model. Finally, our analyses indicate that consumption of six S. cearensis fruits would equal the daily requirements of capuchins for β‐carotene, and the consumption of 1.22 g·day−1 of M. dichotoma encased fruit or 1.0 g·day−1 of S. cearensis can supply capuchin's daily requirement of vitamin C. So, specific nutritional requirements may play a role in explaining the continuous consumption of encased fruit and customary use of stones to crack open encased fruit. Am. J. Primatol. 74:332–343, 2012. © 2011 Wiley Periodicals, Inc.
Efficient Nonlinear Optical Properties of Dyes Confined in Interlayer Nanospaces of Clay Minerals
Authors: Suzuki Yasutaka , Tenma Yuta , Nishioka Yukihiro , Kawamata Jun 
Published: April 2012

AbstractNonlinear optical (NLO) responses from organic dyes can be maximized when the dyes are aligned in appropriate manners in bulk materials. The use of restricted nanospaces provided by interlayer spacing of inorganic layered materials is a promising strategy for imposing suitable molecular alignments for NLO materials on dyes. The hybrid materials thus obtained exhibit salient NLO responses owing to the improved molecular orientation. In some cases, extension of the π‐electron system as a consequence of improved molecular planarity, obtained by the intercalation of a dye into the 2‐dimensional interlayer space of an inorganic layered material, is also observed as a factor that enhances NLO responses of chromophores at the molecular level. This review focuses on recent progress in the strategies for controlling the molecular orientation of NLO‐phores by employing clay minerals, which are one of the typical inorganic layered materials. In addition, development of a means for fabricating composites that satisfy the properties of an optical material, such as a sufficient size and thickness, a flat surface, and low light‐scattering characteristics is required to utilize the superior NLO properties observed for clay/dye hybrid materials for practical applications. A novel means for obtaining such a hybrid material is also outlined.
Periodicity and time trends in the prevalence of total births and conceptions with congenital malformations among Jews and Muslims in Israel, 1999‐2006: A time series study of 823,966 births
Authors: Agay‐Shay Keren , Friger Michael , Linn Shai , Peled Ammatzia , Amitai Yona , Peretz Chava 
Published: April 2012

AbstractBACKGROUND Congenital malformations (CMs) are a leading cause of infant disability. Geophysical patterns such as 2‐year, yearly, half‐year, 3‐month, and lunar cycles regulate much of the temporal biology of all life on Earth and may affect birth and birth outcomes in humans. Therefore, the aim of this study was to evaluate and compare trends and periodicity in total births and CM conceptions in two Israeli populations. METHODS Poisson nonlinear models (polynomial) were applied to study and compare trends and geophysical periodicity cycles of weekly births and weekly prevalence rate of CM (CMPR), in a time‐series design of conception date within and between Jews and Muslims. The population included all live births and stillbirths (n = 823,966) and CM (three anatomic systems, eight CM groups [n = 2193]) in Israel during 2000 to 2006. Data were obtained from the Ministry of Health. RESULTS We describe the trend and periodicity cycles for total birth conceptions. Of eight groups of CM, periodicity cycles were statistically significant in four CM groups for either Jews or Muslims. Lunar month and biennial periodicity cycles not previously investigated in the literature were found to be statistically significant. Biennial cycle was significant in total births (Jews and Muslims) and syndactyly (Muslims), whereas lunar month cycle was significant in total births (Muslims) and atresia of small intestine (Jews). CONCLUSION We encourage others to use the method we describe as an important tool to investigate the effects of different geophysical cycles on human health and pregnancy outcomes, especially CM, and to compare between populations. Birth Defects Research (Part A) 2012. © 2012 Wiley Periodicals, Inc.
Aggregation and Supramolecular Membrane Interactions that Influence Anion Transport in Tryptophan‐Containing Synthetic Peptides
Authors: Daschbach Megan M. , Negin Saeedeh , You Lei , Walsh Matthew , Gokel George W. 
Published: April 2012

AbstractSelf‐assembly is a desired property in supramolecular chemistry, but extensive aggregation may be counterproductive. Rigid systems typically have better organization, but are inherently less dynamic. This work shows that ion transport by amphiphilic heptapeptides (synthetic anion transporters or SATs) is affected by aggregation of the monomers in the bulk aqueous phase to which they are added and within the bilayer. Ion transport was assessed for all compounds by assay of Cl− release from liposomes. The mechanism of ion transport was confirmed by planar bilayer conductance studies for two compounds at opposite ends of the efficacy scale. Dynamic light scattering, the Langmuir trough, transmission electron microscopy, ion release from liposomes, and planar bilayer conductance studies were used to assess the importance of self‐assembly versus aggregation in ion transport. Generally, greater aggregation was has an adverse effect on the transport, although at least dimerization is required for amphiphilic heptapeptides to readily transport Cl−. Anion transport in these systems was found to be sensitive to changes in the C‐terminal portion of the (Gly)3Pro(Gly)3 sequence. Moreover, a significant difference in transport efficacy was apparent when L‐Trp was replaced by D‐Trp in the same position.
ChemInform Abstract: Segregation of Calcium and Magnesium into Different Substructures. Ca4Ag0.948Mg and Other Compounds with Gd4RhIn‐Type Structure.
Authors: Kersting Marcel , Matar Samir F. , Schwickert Christian , Poettgen Rainer 
Published: April 2012

AbstractThe compounds Ln4PdMg (Ln: Ca, Eu, Tb—Lu), Ln4AgMg (Ln: Ca, Yb), Ln4PtMg (Ln: Eu, Tb—Lu), and Ln4AuMg (Ln: Ca, Eu, Yb) are prepared by induction melting of the elements.
ChemInform Abstract: Modular Metal Chalcogenide Chemistry: Secondary Building Blocks as a Basis of the Silicate‐Type Framework Structure of CsLiU(PS4)2.
Authors: Neuhausen Christine , Rocker Frank , Tremel Wolfgang 
Published: April 2012

AbstractThe new title compound is synthesized from a mixture of U, P2S5, Li2S, Cs2S, and S in the molar ratio 2:2:1:1:4 (sealed silica tube, 700 °C, 3 d).
ChemInform Abstract: Applications of Multicomponent Assembly Processes to the Facile Syntheses of Diversely Functionalized Nitrogen Heterocycles.
Authors: Donald James R. , Granger Brett A. , Hardy Simon , Sahn James J. , Martin Stephen F. 
Published: April 2012

AbstractThe sequential multicomponent assembly process/cyclization approach is extended for the diversity oriented synthesis of skeletally distinct unnatural products containing fused tetrahydroisoquinolines, 2‐aryl piperidines, e.g. (XXIX), benzodiazepines, e.g. (IV), isoindolinones, e.g. (XII), and norbenzomorphans, e.g. (XIX).
ChemInform Abstract: Facile Aromatic Finkelstein Iodination (AFI) Reaction in 1,3‐Dimethyl‐2‐imidazolidinone (DMI).
Authors: Yamashita Ken‐Ichi , Tsuboi Michihiro , Asano Motoko S. , Sugiura Ken‐Ichi 
Published: April 2012

AbstractDMI is found to accelerate the process and allows the preparation of products which are not accessible by other methods.
ChemInform Abstract: Highly Efficient and Selective Reduction of Nitroarenes with Hydrazine over Supported Rhodium Nanoparticles.
Authors: Luo Pingfei , Xu Kunling , Zhang Rui , Huang Lei , Wang Jun , Xing Weihong , Huang Jun 
Published: April 2012

AbstractA rhodium/porous ionic copolymer nanocatalyst can be used at low loading (0.1‐1.0 mol%) for the selective reduction of the nitro group of nitroarenes in the presence of halide (F, Cl, Br, I), CN, NH2, OH, amide, ester, and alkene substituents to give the corresponding anilines quantitatively.
ChemInform Abstract: (.+‐.)‐Camphor‐10‐sulfonic Acid Catalyzed Direct One‐Pot Three‐Component Mannich Type Reaction of Alkyl (Hetero)aryl Ketones under Solvent‐Free Conditions: Application to the Synthesis of Aminochromans.
Authors: Kundu Kshama , Nayak Sandip K. 
Published: April 2012

AbstractThe present new method is applicable to various (hetero)aromatic ketones and different aromatic aldehydes and amines.
ChemInform Abstract: Straightforward Zinc‐Catalyzed Transformation of Aldehydes and Hydroxylamine Hydrochloride to Nitriles.
Authors: Enthaler Stephan , Weidauer Maik , Schroeder Fanny 
Published: April 2012

AbstractAldoximes, generated in situ from aldehydes (I) or (III) and NH2‐OH·HCl, undergo zinc‐catalyzed dehydration to provide the corresponding nitriles.
ChemInform Abstract: Stereoselective Synthesis of (Z)‐1,2‐Dithio‐1‐alkenes via Copper‐Catalyzed Thiolation of (Z)‐2‐Bromovinyl Sulfides.
Authors: Xu Hui , Chen Wanzhi , Chen Jiuxi , Wu Huayue 
Published: April 2012

AbstractFor the presented concise synthesis of the title compounds an inexpensive catalyst and readily available starting materials are used.
ChemInform Abstract: Biphenyl‐Based Diaminophosphine Oxides as Air‐Stable Preligands for the Nickel‐Catalyzed Kumada—Tamao—Corriu Coupling of Deactivated Aryl Chlorides, Fluorides, and Tosylates.
Authors: Jin Zhong , Li Yan‐Jing , Ma Yong‐Qiang , Qiu Ling‐Ling , Fang Jian‐Xin 
Published: April 2012

AbstractA new class of air‐ and moisture‐stable phosphine ligands is developed for the Ni‐catalyzed cross‐coupling of electronically deactivated aryl chlorides, fluorides, and tosylates with Grignard reagents.
ChemInform Abstract: Complete 2,5‐Diastereocontrol in the Organocatalytic Enantioselective [3 + 2] Cycloaddition of Enals with Azomethine Ylides Derived from α‐Iminocyanoacetates: Asymmetric Synthesis of Pyrrolidines with Four Stereocenters.
Authors: Reboredo Silvia , Vicario Jose L. , Badia Dolores , Carrillo Luisa , Reyes Efraim 
Published: April 2012

AbstractThe title cycloaddition reaction provides access towards pyrrolidines (III) with four stereocenters, one of them being a quaternary stereocenter, in excellent diastereo‐ and high enantioselectivities.
ChemInform Abstract: Copper‐Catalyzed Cascade Reaction for Practical and Efficient Synthesis of Alkyl 2H‐Isoindole‐1‐carboxylates.
Authors: Biswas Subhasish , Nayak Maloy , Kanojiya Sanjeev , Batra Sanjay 
Published: April 2012

AbstractA copper‐catalyzed condensation—α‐arylation cascade reaction of o‐halobenzaldehydes (I) with glycine methyl ester (II) provides access towards title isoindolecarboxylates (III) in good yields.
ChemInform Abstract: Copper‐Catalyzed Aerobic Oxidative Intramolecular C—H Amination Leading to Imidazobenzimidazole Derivatives.
Authors: Wang Xiaoqiang , Jin Yunhe , Zhao Yufen , Zhu Lin , Fu Hua 
Published: April 2012

AbstractThe procedure provides a new and highly efficient approach to biologically important derivatives.
ChemInform Abstract: A Convenient Method for the Synthesis of 2‐[(5‐Benzyl‐1,3‐thiazol‐1‐yl)imino]‐1,3‐thiazolidin‐4‐one Derivatives.
Authors: Ostapiuk Yuri V. , Obushak Mykola D. , Matiychuk Vasyl S. , Naskrent Marek , Gzella Andrzej K. 
Published: April 2012

AbstractNucleophilic substitution of easily prepared precursors (III) with KSCN is followed by spontaneous cyclization/rearrangement to yield the title compounds (V).
ChemInform Abstract: Simple Method for the Synthesis of 3‐(Pyrrolidin‐1‐yl)piperidine.
Authors: Smaliy R. V. , Chaykovskaya A. A. , Yurchenko A. A. , Lakhtadyr A. I. , Yurchenko S. A. , Shtil N. A. , Kostuk A. N. 
Published: April 2012

AbstractA novel two‐step access to the title compound (IV) is described.
ChemInform Abstract: Highly Selective Palladium‐Catalyzed Intramolecular Chloroamination of Unactivated Alkenes by Using Hydrogen Peroxide as an Oxidant.
Authors: Yin Guoyin , Wu Tao , Liu Guosheng 
Published: April 2012

AbstractThe new method uses an environmentally benign catalytic system, in which H2O2 is used as oxidant and CaCl2 as chloride source.
ChemInform Abstract: Effects of Substituent and Catalyst on the Intramolecular Povarov Reaction—Synthesis of Chromenonaphthyridines.
Authors: Maiti Sourav , Panja Suman Kalyan , Sadhukhan Koushik , Ghosh Jaydip , Bandyopadhyay Chandrakanta 
Published: April 2012

AbstractNovel target compounds are synthesized via in situ formation of aldimines and subsequent intramolecular imino‐Diels—Alder reaction.
ChemInform Abstract: Synthesis of Alkyl Hexahydropyrazino[1,2‐c]pyrimidine‐9‐carboxylates
Authors: Vovk M. V. , Kushnir O. V. , Mel'nichenko N. V. , Tsymbal I. F. 
Published: April 2012

Abstractvia cyclocondensation of 3‐alkoxycarbonylmethylidenepiperazinones (I) with α‐chlorobenzyl isocyanates or 1‐aryl‐2,2,2‐trifluoroethyl isocyanates
ChemInform Abstract: Inhibitory Constituents of Nardostachys chinensis on Nitric Oxide Production in RAW 264.7 Macrophages.
Authors: Hwang Bang Yeon , et al. et al. 
Published: April 2012

AbstractThe activity‐guided fractionation of the MeOH extract of the rhizomes of Nardostachys chinensis leads to the isolation of sesquiterpenoids narchinol B (Ia) and C (Ib) along with 10 known compounds.
ChemInform Abstract: Asymmetric Synthesis of Polyhydroxylated N‐Alkoxypiperidines by Ring‐Closing Double Reductive Amination: Facile Preparation of Isofagomine and Analogues.
Authors: Malik Gaelle , Guinchard Xavier , Crich David 
Published: April 2012

AbstractA new route to title compounds is based on the formation and amination of cyclic acetals of type (III)/(VIII).
ChemInform Abstract: Synthesis, Ion Exchange Properties, Analytical and Catalytic Applications of Nano‐Sized Cerium Zirconium Phosphate.
Authors: Preetha B. , Janardanan C. 
Published: April 2012

AbstractA new inorganic cation exchange material, CeO2·2ZrO2·1.25P2O5 ·14H2O is synthesized by mixing solutions of NaH2PO4, ZrOCl2 and Ce(SO4)2 (pH 1, 20 °C, 24 h).
ChemInform Abstract: Dual Activation in Organocatalysis: Design of Tunable and Bifunctional Organocatalysts and Their Applications in Enantioselective Reactions
Authors: Lu Liang‐Qiu , An Xiao‐Lei , Chen Jia‐Rong , Xiao Wen‐Jing 
Published: April 2012

AbstractReview: about 50 refs.
Synthesis, Structure Analysis, and Antitumor Evaluation of 3,6‐Dimethyl‐1,2,4,5‐tetrazine‐1,4‐dicarboxamide Derivatives
Authors: Rao Guo‐Wu , Guo Yan‐Mei , Hu Wei‐Xiao 
Published: April 2012

Abstract3,6‐Dimethyl‐1,2,4,5‐tetrazine‐1,4‐dicarboxamide derivatives were synthesized, and their structures were confirmed by single‐crystal X‐ray diffraction. This reaction yields the 1,4‐dicarboxamide derivatives rather than the 1,2‐dicarboxamide derivatives. Their in vitro antitumor activities were evaluated against SGC‐7901, HO‐8910, MCF‐7, and A‐549 cells. The results showed several compounds to be endowed with cytotoxicity in the low micromolar range. One compound (IC50=0.57 μM) was further evaluated in vivo against an A‐549 xenograft in BALB/cA nude mice; it effected 76.4 % inhibition of tumor weight through intraperitoneal (i.p.) administration of 40 mg kg−1 body weight. Moreover, its acute toxicity was evaluated, and the i.p. LD50 value was 325 mg kg−1 in mice.
Reduction of the chemical master equation for gene regulatory networks using proper generalized decompositions
Authors: Ammar Amine , Cueto Elías , Chinesta Francisco 
Published: April 2012

SUMMARYThe numerical solution of the chemical master equation (CME) governing gene regulatory networks and cell signaling processes remains a challenging task owing to its complexity, exponentially growing with the number of species involved. Although most of the existing techniques rely on the use of Monte Carlo‐like techniques, we present here a new technique based on the approximation of the unknown variable (the probability of having a particular chemical state) in terms of a finite sum of separable functions. In this framework, the complexity of the CME grows only linearly with the number of state space dimensions. This technique generalizes the so‐called Hartree approximation, by using terms as needed in the finite sums decomposition for ensuring convergence.But noteworthy, the ease of the approximation allows for an easy treatment of unknown parameters (as is frequently the case when modeling gene regulatory networks, for instance). These unknown parameters can be considered as new space dimensions. In this way, the proposed method provides solutions for any value of the unknown parameters (within some interval of arbitrary size) in one execution of the program. Copyright © 2012 John Wiley & Sons, Ltd.
Flow cytometric detection of liposomal cytarabine in cerebrospinal fluid of patients treated with intrathecal chemotherapy
Authors: Stacchini Alessandra , Demurtas Anna , Aliberti Sabrina 
Published: April 2012

AbstractWe report the unusual flow cytometric detection of liposomes in the cerebrospinal fluid of patients with aggressive non‐Hodgkin's lymphoma and acute myeloid leukemia, treated with intrathecal liposomal cytarabine. © 2012 International Clinical Cytometry Society
A simple flow cytometric assay for routine paroxysmal nocturnal hemoglobinuria testing based on immature reticulocytes and granulocytes
Authors: Tsagarakis Nikolaos J. , Paterakis George 
Published: April 2012

AbstractBackground:The aim of this study was to test an easy‐to‐perform flow cytometric (FCM) assay for the routine investigation for diagnosis of paroxysmal nocturnal hemoglobinuria (PNH), through the simultaneous detection of PNH clones on immature reticulocytes (i‐RET) and granulocytes.Methods:During the last 5 years, eight patients were diagnosed with PNH in our laboratory, among 90 patients prospectively studied for PNH. The determination of glycosylphosphatidylinositol (GPI) deficient cells on the erythroid lineage was made with a two‐color FCM assay of CD71 and CD59, evaluating the PNH clone on i‐RET. Three color combinations based on CD66b/CD16/CD45 and CD59/CD24/CD45 were used for the determination of GPI‐deficient granulocytes.Results:In all the patients with PNH, the PNH clones determined with CD71(+)CD59(−) red blood cells (RBC) were nearly identical to the respective clones determined with CD16(dim/−)/CD66b(−) and CD59(−)/CD24(−) granulocytes, in contrast to the clones determined with CD59‐deficient erythrocytes only, which were significantly lower.Conclusions:Our results indicate that the simultaneous assessment of the PNH clone on CD71(+)/CD59(−)i‐RET and CD16(dim/−)/CD66b(−) granulocytes, could offer a reliable method of two series PNH screening, at low cost and with ease of application. © 2012 International Clinical Cytometry Society
Double negative Treg cells promote nonmyeloablative bone marrow chimerism by inducing T‐cell clonal deletion and suppressing NK cell function
Authors: Su Ye , Huang Xuyan , Wang Shuang , Min Wei‐Ping , Yin Ziqin , Jevnikar Anthony M. , Zhang Zhu‐Xu 
Published: April 2012

The establishment of immune tolerance and prevention of chronic rejection remain major goals in clinical transplantation. In bone marrow (BM) transplantation, T cells and NK cells play important roles for graft rejection. In addition, graft‐versus‐host‐disease (GVHD) remains a major obstacle for BM transplantation. In this study, we aimed to establish mixed chimerism in an irradiation‐free condition. Our data indicate that adoptive transfer of donor‐derived T‐cell receptor (TCR) αβ+CD3+CD4–CD8–NK1.1– (double negative, DN) Treg cells prior to C57BL/6 to BALB/c BM transplantation, in combination with cyclophosphamide, induced a stable‐mixed chimerism and acceptance of C57BL/6 skin allografts but rejection of third‐party C3H (H‐2k) skin grafts. Adoptive transfer of CD4+ and CD8+ T cells, but not DN Treg cells, induced GVHD in this regimen. The recipient T‐cell alloreactive responsiveness was reduced in the DN Treg cell‐treated group and clonal deletions of TCRVβ2, 7, 8.1/2, and 8.3 were observed in both CD4+ and CD8+ T cells. Furthermore, DN Treg‐cell treatment suppressed NK cell‐mediated BM rejection in a perforin‐dependent manner. Taken together, our results suggest that adoptive transfer of DN Treg cells can control both adoptive and innate immunities and promote stable‐mixed chimerism and donor‐specific tolerance in the irradiation‐free regimen.