bluuebunny/crossref_metadata_2025_split huggingface dataset:
The role of VISTA engagement in limiting neutrophil-mediated inflammation
Authors: Nowak Elizabeth C. , Li Jiannan , ElTanbouly Mohamed A. , Davis Wilson L. , Sergent Petra , Mendyka Lindsay K. , Lines J. Louise , Smits Nicole C. , Mabaera Rodwell , Rajanna Shibani , Carriere Catherine , Koehn Brent , Blazar Bruce R. , Burns Christopher M. , Noelle Randolph J. , Skopelja-Gardner Sladjana 
Published: May 2024

AbstractA growing body of evidence suggests that VISTA, an immune checkpoint inhibitory receptor, plays a central role in the regulation of innate immunity in the settings of inflammatory diseases and cancer. Neutrophils are among the cells that have the highest membrane density of surface VISTA. Targeting VISTA on neutrophils with an agonist antibody resulted in a striking reduction in their LPS-induced peripheral accumulation. Fc receptor engagement was required for anti-VISTA antibody to mediate its effects on neutrophils. Concomitant with reduced peripheral neutrophil cell numbers, anti-VISTA antibody treatment increased neutrophil cell death in the liver. In a murine model of neutrophil-mediated arthritis, agonist anti-VISTA antibody treatment ameliorated disease severity, which was associated with reduced myeloperoxidase activity in the joints. These studies add to a growing spectrum of negative regulatory functions that VISTA performs in controlling inflammation through the innate and adaptive arms of the immune system that has implications for translation into the clinic.
CD74+fibroblasts proliferate upon mechanical stretching to promote angiogenesis in keloid
Authors: Zhang Jingheng , Li Shuyao , Kuang Chunmei , Shen Yunfan , Yu Haibin , Chen Fang , Tang Ruijun , Mao Song , Lv Lu , Qi Min , Zhang Jianglin , Yuan Kai 
Published: May 2024

AbstractThe healing of human skin wounds is susceptible to perturbation caused by excessive mechanical stretching, resulting in enlarged scars, hypertrophic scars, or even keloids in predisposed individuals. Keloids are fibro-proliferative scar tissues that extend beyond the initial wound boundary, consisting of the actively progressing leading edge and the quiescent center. The stretch-associated outgrowth and enhanced angiogenesis are two features of the leading edge of keloids. However, which cell population is responsible for transducing the mechanical stimulation to the pathological alterations of keloid tissues remains unclear. Herein, through joint analysis of single-cell RNA sequencing of keloid specimens and RNA sequencing of stretched keloid fibroblasts, we identified CD74+fibroblasts, a previously unappreciated subset of fibroblasts, as a key player in stretch-induced keloid progression. Examination of macrophage markers suggested a possible myeloid origin of the CD74+fibroblasts. Immunostaining of keloid cryosections depicted a predominant distribution of CD74+fibroblasts in the leading edge, interacting with vasculature. CD74+fibroblasts possessed pro-angiogenic and migratory capacities, as revealed byin vitrotranswell and tube formation assays on purified CD74+fibroblasts. Additionally, these cells underwent proliferation upon stretching, through PIEZO1-mediated calcium influx and the downstream ERK and AKT signaling. Collectively, our findings propose a model wherein CD74+fibroblasts serve as pivotal drivers of stretch-induced keloid progression, fueled by their proliferative, pro-angiogenic, and migratory capacities. Targeting the attributes of CD74+fibroblasts hold promise as a therapeutic strategy for keloid management.Significance statementKeloids are fibro-proliferative scars resulting from aberrant skin wound healing processes, consisting of the actively progressing leading edge and the quiescent center. Mechanical stretching and neo-vascularization have both been implicated in keloid progression, yet little is known about whether they are interconnected. Herein, we demonstrated that CD74+fibroblasts, a previously undiscovered fibroblast subset, possessed heightened pro-angiogenic and migratory capacities, and underwent proliferation upon mechanical stretching, thereby facilitating the progression of the leading edge of keloids. Examination of macrophage markers suggested a possible myeloid origin of CD74+fibroblasts. Our findings uncover the connection between stretch-induced keloid progression and neo-vascularization through CD74+fibroblasts and provide valuable insights into potential therapeutic interventions.
Effects of renormalon scheme and perturbative scale choices on determinations of the strong coupling from
e+e−
event shapes
Authors: Bell Guido , Lee Christopher , Makris Yiannis , Talbert Jim , Yan Bin 
Published: May 2024

We study the role of renormalon cancellation schemes and perturbative scale choices in extractions of the strong coupling constant αs(mZ) and the leading nonperturbative shift parameter Ω1 from resummed predictions of the e+e− event shape thrust. We calculate the thrust distribution to NL3L′ resummed accuracy in soft-collinear effective theory (SCET) matched to the fixed-order O(αs2) prediction, and perform a new high-statistics computation of the O(αs3) matching in , although we do not include the latter in our final αs fits due to some observed systematics that require further investigation. We are primarily interested in testing the phenomenological impact sourced from varying amongst three renormalon cancellation schemes and two sets of perturbative scale profile choices. We then perform a global fit to available data spanning center-of-mass energies between 35–207 GeV in each scenario. Relevant subsets of our results are consistent with prior SCET-based extractions of αs(mZ), but we are also led to a number of novel observations. Notably, we find that the combined effect of altering the renormalon cancellation scheme and profile parameters can lead to few-percent-level impacts on the extracted values in the αs−Ω1 plane, indicating a potentially important systematic theory uncertainty that should be accounted for. We also observe that fits performed over windows dominated by dijet events are typically of a higher quality than those that extend into the far tails of the distributions, possibly motivating future fits focused more heavily in this region. Finally, we discuss how different estimates of the three-loop soft matching coefficient cS˜3 can also lead to measurable changes in the fitted {αs,Ω1} values.

Published by the American Physical Society
2024
A new method for estimating liquidity and stock returns in Indian stock market
Authors: Sethy Tapas Kumar , Tripathy Naliniprava 
Published: May 2024

PurposeThis study aims to explore the impact of systematic liquidity risk on the averaged cross-sectional equity return of the Indian equity market. It also examines the effects of illiquidity and decomposed illiquidity on the conditional volatility of the equity market.Design/methodology/approachThe present study employs the Liquidity Adjusted Capital Asset Pricing Model (LCAPM) for pricing systematic liquidity risk using the Fama & MacBeth cross-sectional regression model in the Indian stock market from January 1, 2012, to March 31, 2021. Further, the study employed an exponential generalized autoregressive conditional heteroscedastic (1,1) model to observe the impact of decomposed illiquidity on the equity market’s conditional volatility. The study also uses the Ordinary Least Square (OLS) model to illuminate the return-volatility-liquidity relationship.FindingsThe study’s findings indicate that the commonality between individual security liquidity and aggregate liquidity is positive, and the covariance of individual security liquidity and the market return negatively affects the expected return. The study’s outcome specifies that illiquidity time series analysis exhibits the asymmetric effect of directional change in return on illiquidity. Further, the study indicates a significant impact of illiquidity and decomposed illiquidity on conditional volatility. This suggests an asymmetric effect of illiquidity shocks on conditional volatility in the Indian stock market.Originality/valueThis study is one of the few studies that used the World Uncertainty Index (WUI) to measure liquidity and market risks as specified in the LCAPM. Further, the findings of the reverse impact of illiquidity and decomposed higher and lower illiquidity on conditional volatility confirm the presence of price informativeness and its immediate effects on illiquidity in the Indian stock market. The study strengthens earlier studies and offers new insights into stock market liquidity to clarify the association between liquidity and stock return for effective policy and strategy formulation that can benefit investors.
The influence of brand awareness on brand equity: an investigation among dentists and their prescription behavior
Authors: Sheikh Alireza , Asemani Newsha 
Published: May 2024

Purpose
This study aims to examine the influence of brand awareness on brand equity with the mediating role of brand association and perceived quality.

Design/methodology/approach
This research is applied in terms of the objective and descriptive survey in terms of methodology because its objective is to describe the studied conditions or phenomena and also the relationship between research variables that have been conducted in the field method.

Findings
The results explained that 53% of respondents are female and 47% of respondents are male. Most respondents are between 30 and 40 years old, and the youngest respondents are less than 30 years old. Most respondents were specialists, and the 134 respondents were subspecialists. The results explained that the significance level of the Kolmogorov–Smirnov test for research variables is less than 0.05 and has an abnormal distribution. The abnormality of the data in this study directed the authors to use PLS software to analyze the data.

Originality/value
To the best of the authors’ knowledge, it is the first time that research is prepared to study the impact of these marketing parameters on dentists’ prescription behavior.
Predicting friction coefficient of textured 45# steel based on machine learning and analytical calculation
Authors: Li Zhenshun , Li Jiaqi , An Ben , Li Rui 
Published: May 2024

Purpose
This paper aims to find the best method to predict the friction coefficient of textured 45# steel by comparing different machine learning algorithms and analytical calculations.

Design/methodology/approach
Five machine learning algorithms, including K-nearest neighbor, random forest, support vector machine (SVM), gradient boosting decision tree (GBDT) and artificial neural network (ANN), are applied to predict friction coefficient of textured 45# steel surface under oil lubrication. The superiority of machine learning is verified by comparing it with analytical calculations and experimental results.

Findings
The results show that machine learning methods can accurately predict friction coefficient between interfaces compared to analytical calculations, in which SVM, GBDT and ANN methods show close prediction performance. When texture and working parameters both change, sliding speed plays the most important role, indicating that working parameters have more significant influence on friction coefficient than texture parameters.

Originality/value
This study can reduce the experimental cost and time of textured 45# steel, and provide a reference for the widespread application of machine learning in the friction field in the future.
Modeling the factors affecting workplace well-being at construction sites: a cross-regional multigroup analysis
Authors: Radzi Afiqah R. , K. S. Anandh , Alias Ahmad Rizal , Algahtany Mohammed , Rahman Rahimi A. 
Published: May 2024

Purpose
A good workplace well-being (WWB) has many positive impacts on individuals and organizations. Prior studies indicate that physical, psychological and social well-being factors positively influence WWB. Nevertheless, it is essential to acknowledge that these factors may exhibit variations across different regions, cultural contexts and workplace environments. Therefore, this study aims to explore and validate the relationships between physical, psychological and social well-being factors and WWB at construction sites across different regions, using Malaysia and India as case studies.

Design/methodology/approach
A conceptual model was proposed between physical, psychological and social well-being factors and WWB at construction sites. Then, a questionnaire survey was developed based on the proposed model and distributed to construction industry practitioners in both countries. In total, 316 responses were collected and analyzed using confirmatory factor analysis and multigroup analysis.

Findings
The analyses indicate that the proposed model on physical, psychological and social well-being factors and WWB at construction sites is valid. Also, the model has no significant differences between the two countries. Thus, the findings show that the physical, psychological and social well-being factors are similarly affecting WWB at construction sites in both countries.

Originality/value
The originality of the study lies in its holistic and cross-regional examination of WWB at construction sites. The insights gained from this study provide evidence for promoting good health and well-being in the construction industry. Moreover, this study seeks to provide insights that transcend geographical boundaries, offering valuable implications for promoting WWB practices in construction projects worldwide.
Inelegant enforcement of anti-corruption laws and good governance: a persistent catalyst for coups d’état and poverty in Africa
Authors: Olujobi Olusola Joshua , Irumekhai Oshobugie Suleiman 
Published: May 2024

Purpose
The purpose of this paper is to scrutinise the intricate relationship between the inadequate enforcement of anti-corruption laws and the application of good governance and the persisting prevalence of coups d'état and poverty in Africa.

Design/methodology/approach
This paper uses a doctrinal legal research approach, synthesising existing literature while extensively analysing primary and secondary legal sources. Its primary aim is to scrutinise the intricate relationship between the inadequate enforcement of anti-corruption laws and the application of good governance and the persisting prevalence of coups d'état and poverty in Africa. The choice of case study countries Burkina Faso, Chad, Gabon, Guinea, Mali, Niger and Sudan stems from their historical significance, regional diversity, data accessibility and potential insights into the interplay among anti-corruption enforcement, governance, poverty and coups d'état in Africa.

Findings
The enforcement of anti-corruption laws and the promotion of good governance are indispensable for democracy and economic stability; their suboptimal enforcement directly contributes to coups d'état and the worsening of poverty in African nations. It emphasises the imperative for African countries to consistently and proficiently enforce anti-corruption laws and adhere to principles of good governance, effectively and responsibly, to mitigate coups d'état and alleviate poverty in the region.

Originality/value
This study designs a model strategy for combating coups d'état and corruption in Africa as contribution to knowledge in the field of study.
Addressing Africa’s carbon dioxide emission: the role of natural resources, control of corruption, voice and accountability and regulatory quality
Authors: Kwakwa Paul Adjei , Aboagye Solomon 
Published: May 2024

PurposeThe study examines the effect of natural resources (NRs) and the control of corruption, voice and accountability and regulatory quality on carbon emissions in Africa. Aside from their individual effects, the moderation effect of institutional quality is assessed.Design/methodology/approachData from 32 African countries from 2002 to 2021 and the fully modified ordinary least squares (FMOLS) and dynamic ordinary least squares (DOLS) regression methods were used for the investigation.FindingsIn the long term, the NRs effect is sensitive to the estimation technique employed. However, quality regulatory framework, robust corruption control and voice and accountability abate any positive effect of NRs on carbon emissions. Institutional quality can be argued to moderate the CO2-emitting potentials of resource extraction in the selected African countries.Practical implicationsEnhancing regulation quality, enforcing corruption control and empowering citizens towards greater participation in governance and demanding accountability are essential catalyst to effectively mitigate CO2 emissions resulting from NRs.Originality/valueThe moderation effect of control of corruption, voice and accountability and regulatory quality on the NR–carbon emission nexus is examined.
Introducing the area under stress–velocity curve: Theory, measurement and association with rock properties
Authors: Sharifi Javad 
Published: May 2024

AbstractSince many years ago, ultrasonic velocity has been used to investigate the physical and mechanical behaviour of rocks, thereby playing an important role in reservoir characterization and seismic interpretation. In order to develop the knowledge of ultrasonic tools, I performed a noble analysis on the ultrasonic behaviour of rocks under confining stress and evaluated a distinctive property of porous media that is measured as the area under the stress–velocity curve (here defined as S*). I further investigated its relationship with elastic and mechanical behaviours of rock. To validate the theoretical framework developed in this work, 20 core plugs from various rock units with complex microstructures were subjected to triaxial compressional tests to calculate their area under the curve. Calculations were made for crack‐closing, elastic and post‐elastic stages (e.g. pore collapse) along the ultrasonic velocity–stress curve. Moreover, the selected samples had their microstructure investigated by thin‐section studies to quantify their porosity and pore type. The results were analysed to check for the effect of pore type on S* in different stages of the stress–velocity curve. Based on the outputs of the analysis of variance and Pearson's correlation coefficient analysis, the curve had its shape and underlying area closely related to the porosity and pore geometry. Indeed, the results showed that the shale and sandstone with micro cracks and carbonate with stiff pores correspond to smaller and larger areas under the curve in crack‐closing and inelastic stages, respectively. Cross‐correlating the results to compressibility (inverse of bulk modulus), it was figured out that the calculated area under curve was well consistent with the compressibility. In addition, S* represents both static and dynamic behaviours of the rock, and the results revealed that the shape and curvature of the stress–velocity curve give valuable information about the rock microstructure. Another finding was the fact that the type of fluid and wave velocity seemingly affect the S*. Our findings can help interpret wave velocity behaviour in reservoir rocks and other stressful porous media.
Functional traits of predators and decomposer prey determine context dependency in trophic control over ecosystems
Authors: Lienau Janey R. , Schmitz Oswald J. 
Published: May 2024

AbstractResearch Highlight: Piccoli, G. C. d. O., Antiqueira, P. A. P., Srivastava, D. S., & Romero, G. Q. (2024). Trophic cascades within and across ecosystems: The role of anti‐predatory defences, predator type and detritus quality. Journal of Animal Ecology, 00, 1–14. https://doi.org/10.1111/1365‐2656.14063. Ecosystem functioning is controlled by the interplay between bottom‐up supply of limiting nutrients and top‐down animal feedback effects. However, the degree of animal versus nutrient control is context‐dependent. A key challenge lies in characterizing this context dependency which is hypothesized to depend on differences in animal functional traits. Reporting on an important experiment, Piccoli et al. (2014) evaluate how interactions among functionally different predators and decomposer prey create context dependency in top‐down control of a model system–tropical bromeliad tank ecosystems. Bromeliad plants hold water in their tanks supporting microcosm ecosystems containing terrestrial and aquatic insect larvae and arachnids. The ecosystems are supported by nutrients in plant litter that rains down from forest canopies into the tanks. Nutrients are released after litter is decomposed by a functionally diverse community of larval insect decomposers that differ in feeding mode and antipredator defence strategy. This decomposer community is preyed upon by an exclusively narrowly ranging aquatic insect larval predator and widely ranging spider predator that crosses between the aquatic and surrounding terrestrial ecosystems. Experimental manipulation of the animal community to test for the degree of control by predators mediated by the functionally diverse prey community included four treatments: (i) a control with the detritivores composing different function groups but without predators, (ii) the cross‐ecosystem spider predator added, (iii) the purely aquatic damselfly larvae predator added and (iv) both predator types added to capture their interacting effect on ecosystem function (decomposition, nutrient release, and plant growth). Notably, the study resolved the causal pathways and strengths of direct and indirect control using structural equation modelling. These findings reveal how context dependency arises due to different capacities of the predators alone and together to overcome prey defences and control their abundances, with attendant cascading effects that diminished as well as enhanced decomposition and nutrient release to support bromeliad plant production. The study reveals that predators have a decided, albeit qualitatively and quantitatively different, hand in shaping the degree of bottom‐up control through feedback effect on the release of limiting nutrients. This ground‐breaking study provides a way forward in understanding the mechanisms determining context dependency in the control over ecosystem functioning.
Musashi orchestrates melanism in Laodelphax striatellus
Authors: Mao Zeping , Wang Biyun , Chen Youyuan , Ying Jinjun , Wang Haiqiang , Li Junmin , Zhang Chuanxi , Zhuo Jichong 
Published: May 2024

AbstractIn insects, melanism, a fundamental pigmentation process, is of significant importance in evolutionary biology due to its complex genetic foundation. We investigated the role of the RNA‐binding gene Musashi (msi) in melanism in Laodelphax striatellus, a Hemiptera species. We identified a single L. striatellus msi homolog, Lsmsi, encoding a 357 amino acid protein with 2 RNA recognition motifs. RNA interference‐mediated knockdown of LsMsi resulted in complete body melanism and increased cuticular permeability. Additionally, we found the involvement of G protein‐coupled receptor A42 and tyrosine hydroxylase (Th) in L. striatellus melanism. Knockdown of LsTh lightened the epidermis, showing dehydration signs, while LsA42 knockdown enhanced LsTh expression, leading to melanism. Surprisingly, Lsmsi knockdown decreased both LsA42 and LsTh expression, which was expected to cause whitening but resulted in melanism. Further, we found that Lsmsi influenced downstream genes like phenoloxidase homolog LsPo and dopa decarboxylase (Ddc) homolog LsDdc in the tyrosine‐mediated melanism pathway. Extending to Nilaparvata lugens and Sogatella furcifera, we demonstrated the conserved role of msi in melanism among Delphacidae. Given MSI proteins’ roles in cancer and tumors in vertebrates, our study is the first to link msi in insects to Delphacidae body color melanization via the tyrosine‐mediated pathway, offering fresh perspectives on the genetic basis of insect melanism and msi functions.