bluuebunny/crossref_metadata_2025_split huggingface dataset:
Revolutionizing Concrete Quality Through Global Innovations
Authors: Sidhi Cahyana Atikha , Romadhon Ilham Fatwa , Jakaria Ribangun Bamban , Wahyuni Hana Catur 
Published: June 2024

The concrete industry, known for producing various concrete products, faces quality challenges evidenced by a 20% defect rate in concrete type G5. SP. 100. 100. 120. 10 MF from August 2022 to January 2023. This study aims to identify the root causes of defects to aid companies in enhancing product quality. Employing qualitative and quantitative methods, including the Seven Tools and Root Cause Analysis (RCA), the research uncovered predominant defects: 681 porous, 312 chipped, 196 cracked, 132 bug hole, 93 shrinkage, 85 lumpy, and 72 other defects. Human, material, machine, method, environmental factors contributed to these defects. Corrective actions were recommended to mitigate defects. The study's limitations include its focus solely on concrete type G5. SP. 100. 100. 120. 10 MF, suggesting future research should encompass all concrete types to provide comprehensive insights for the industry.
Highlight:

Automotive innovation drives rapid progress in technology and productivity.
Consumers prioritize quality and quantity in vehicle selection.
Modified racing rollers enhance motorcycle performance, boosting power and torque.

Keywoard: Innovation, Technology, Automotive, Development, Productivity
Revolutionizing Warehouse Efficiency with Shared and Class-Based Storage
Authors: Supriyadi Deddy , Cahyana Atikha Sidhi 
Published: June 2024

This study addresses inefficiencies in the warehouse layout of a paper production company in Pasuruan, East Java, which led to delayed deliveries. By implementing shared storage (SS) using FIFO and class-based storage (CBS), the research aimed to optimize space and improve material handling efficiency. Data collection involved observation, interviews, and company records. The proposed layout reduced space usage from 59.45% to 16.95% and achieved significant time savings: 17.84% for brown paper, 8.84% for white paper, and 28.51% for custom-colored paper. The findings suggest that a systematic layout can greatly enhance warehouse efficiency. Future studies should consider the cost factors associated with these improvements.
Highlights:

Space Efficiency: Reduced usage from 59.45% to 16.95%.
Time Savings: Up to 28.51% for custom-colored paper.
Data-Driven: Used observations, interviews, and records for layout optimization

Keywords: Warehouse layout, material handling, shared storage, class-based storage, efficiency improvement
Mineralogical composition, isotopic and geochemical characteristics of Pleistocene glendonites from the outcrops of Bol’shaya Balakhnya River, eastern Taimyr, Russia
Authors: Vasileva Kseniia , Ershova Victoria , Rogov Mikhail , Gritsenko Julia , Maximov Fedor , Ovsepyan Yaroslav , Okuneva Tatiana , Rybakova Anna , Kiseleva Daria , Vereshchagin Oleg 
Published: June 2024

ABSTRACT
We present a complex study on mineralogical, U/Th dating, isotopic and geochemical characteristics of Pleistocene glendonites (calcite pseupomorphs after ikaite) from the outcrops of Bol’shaya Bakakhnya valley, eastern Taimyr, Russia. Based on the U/Th dating of the glendonites (37 ± 7 ka) we propose that the glendonites and host sediments were formed during the Karginsky interstadial (22–50 ka)—this data corresponds well with published ages of foraminifers and wood fragments from Karginsky deposits of eastern Taimyr. The main factors leading to ikaite crystallization was presence of organic matter (δ13C varies from –5 to –40‰ V-PDB) in the host clayey sediments and low temperatures (&lt; 7°C) of bottom water. Isotope (δ18O ratios vary from –8 to –33.9‰ V-PDB) and geochemical (PAAS-normalized patterns of rare earth elements) characteristics of the studied glendonites confirm that ikaite crystallization and transformation was influenced by seawater. Carbon was derived from dissolved inorganic carbon, decomposed organic matter, and probably methane. Some glendonites are surrounded by concretions (host rock cemented by calcite). The isotopic characteristics of the host concretions and glendonites are similar, so we assume that glendonites and host nodules were formed by the same processes—sulfate reduction coupled with anaerobic decomposition of organic matter. Nevertheless, geochemical characteristics of the host concretions and glendonites differ: Mg/Ca ratio and values of Fe, Mn, Zn, Cd, and U are higher in host concretion than in glendonite. This may reflect differences in crystalline structure of ikaite and high magnesium calcite.
Spaceflight alters host-gut microbiota interactions
Authors: Brereton Nicholas , Gonzalez Emmanuel , Lee Michael , Tierney Braden , Lipieta Natalie , Flores Pamela , Mirshra Maya , Beckett Laura , Karouia Fathi , Barker Richard , Jansen Rick , Green Stefan , Weging Silvio , Kelliher Julia , Singh Nitin , Bezdan Daniela , Galazka Jonathan 
Published: June 2024

Abstract

The rodent habitat on the International Space Station has provided crucial insights into the impact of spaceflight on mammals, inducing symptoms characteristic of liver disease, insulin resistance, osteopenia, and myopathy. Although these physiological responses can involve the microbiome when observed on Earth, changes in host-microbiota interactions during spaceflight are still being elucidated. Here, we explore murine gut microbiota and host gene expression in the colon and liver after 29 and 56-days of spaceflight using multiomic analyses of the Rodent Research 6 mission. Hybrid amplicon and whole metagenome sequencing revealed significant spaceflight-associated changes in 43 microbiome species, including relative reductions in bile acid and butyrate metabolising bacteria like Extibacter muris and Dysosmobacter welbionis. Functional prediction indicate over-representation of fatty acid and bile acid metabolism, extracellular matrix interactions, and antibiotic resistance genes within the gut microbiome, while host intestinal and hepatic gene expression described corresponding changes to host bile acid and energy metabolism, and immune suppression from spaceflight. Taken together, these changes imply that interactions at the host-gut microbiome interface contribute to spaceflight pathology and highlight how these interactions might critically influence human health and the feasibility of long-duration spaceflight.
The nature of the relationship between obesity and mental health: An IMI2 SOPHIA qualitative study
Authors: Farrell Emma , Nadglowski Joseph , Hollmann Eva , Roux Carel Le , McGillicuddy Deirdre 
Published: June 2024

Abstract

Introduction:
Obesity is associated with poor mental health. However, the nature and direction of this association is not well understood. This study is the first to qualitatively examine the nature of the relationship between obesity and mental health from the perspective of people living with obesity.
Methods
A qualitatively-driven multimethodological research design was implemented, integrating hermeneutic phenomenological conversational interviews and focus group methodologies. Data from these interviews were transcribed verbatim and analysed using thematic analysis.
Results
Four major themes emerged related to: (1) Mental health difficulties and obesity: Chicken or egg?, (2) Obesity as “a literal not fitting in”, (3) Obesity as a response to trauma, (4) The importance of mental health support in obesity treatment. People living with obesity struggled to determine the direction of the relationship between obesity and mental health but identified the mental health impact of “not fitting in” and obesity as a response to, or repellent against, childhood abuse or trauma.
Conclusion
Our findings offer a qualitative insight into the bidirectional nature of the relationship between obesity and mental health from the perspective of people living with obesity.
ANN and Machine Learning based predictions of MRR in AWSJ Machining of CFRP composites
Authors: Ramesha K , Santhosh N , Praveena B A , Manjunath C , Nagaraj Banakara , Johar MGM , Jaharadak Adam Amril , Rajhi Ali A. , Alamri Sagr , Duhduh Alaauldeen A. , N CHANNA KESHAVA NAIK 
Published: June 2024

Abstract

The study assesses the efficacy of Abrasive Water Suspension Jet (AWSJ) Machining, a non-conventional technique based on erosion principles, with a specific emphasis on its use in machining carbon fiber-reinforced plastics (CFRP) composites. The analysis examines critical process variables, including Speed, Feed, and Standoff distance, to evaluate their influence on Material Removal Rate (MRR), during underwater cutting operations. The results unambiguously support the superiority of underwater cutting. Expanding the diameter of the jet in underwater cutting improves both the width of the cut and the roughness of the surface. This also helps reduce vibrations in the nozzle when operating at high pressures, resulting in a smaller cut and a smoother surface. This highlights the effectiveness of underwater cutting in generating accurate machining results. In addition, the study utilizes machine learning (ML) models such as Random Forest and XGBoost to enhance the optimization of MRR, a crucial parameter in composite machining. The results demonstrate exceptional performance across all models, with XGBoost exhibiting outstanding accuracy and efficiency on both the training and test datasets. The comparative analysis reveals the competitive performance of Random Forest XGBoost and Artificial Neural Network (ANN) in optimizing MRR. These models achieve notable accuracy scores in both training and test sets, surpassing the regular statistical methods such as the Response Surface Methodology (RSM).
Anti-inflammatory Effect and Plasma Bupivacaine Concentrations After Transversus Abdominis Plane Block for Living Liver Donors: Prospective, Randomized, Blinded Clinical Trial
Authors: Yalin Mehmet Rıdvan , Erdogan Mehmet Ali , Ucar Muharrem , Uremis Muhammed Mehdi , Colak Yusuf Ziya , Ozdemir Emine , Ugur Yılmaz , Ozgul Ulku , Erdogan Selim , Kacmaz Osman , Colak Cemil , Toprak Huseyin İlksen 
Published: June 2024

Abstract

Objective
Transversus abdominis plane (TAP) blocks were reported to reduce postoperative pain and opioid use. Local anesthetics modulate the local and systemic inflammatory reaction. Our aim was to examine the effect of TAP block with bupivacaine on the anti-inflammatory response in living liver donors (LLDs).
Methods
The randomized prospective clinical study was carried out 72 LLDs, aged 18–65 scheduled for right hepatectomy. TAP blocks were performed bilaterally with ultrasound guidance using 1.5 mg/kg of 0.5% bupivacaine for Group 2. Group 1 patients were control group. In both groups, blood samples were obtained preoperatively, 30 minutes and 2, 6, and 24 hours following injection for cytokine measurement. In Group 2, to examine the plasma bupivacaine level, blood samples were obtained preoperatively as well as 30 minutes and 1, 2, 6, 12, and 24 hours following injection. The primary outcome was to assess the effect of TAP block on the inflammatory response with cytokine levels.
Results
No difference was observed between cytokine levels (Tumor necrosis factor-alpha (TNF-α), interleukin-1 (IL-1) and interleukin 6 (IL-6) between Groups Significant positive correlations were observed between the plasma bupivacaine concentration and IL-1 and IL-6 levels at the 2nd, 6th and 24th hours
Conclusions
TAP block had no effect on the plasma cytokine concentration. Significant positive correlations were noted between the plasma bupivacaine concentration and IL-1 and IL-6 levels.
Imaging material yielding and phase transitions in shock-compressed matter.
Authors: Pandolfi Silvia , Galtier Eric , Lee Hae Ja , Hodge Daniel , Makita Mikako , Khaghani Dimitri , Cunningham Eric , Hart Phiip , Ricks Matthew , Hatcher Thomas , Yunus Sameen , Heimann Phillip , Dyer Gilliss , Sandberg Richard , Gleason Arianna , Nagler Bob 
Published: June 2024

Abstract

Decades of research have investigated the mechanical properties of matter under extreme conditions, exploring how materials deform, yield, and fail when subjected to high strain rates. While plasticity codes and computational methods can provide atomic-scale precision, reliable experimental benchmarks are needed to validate these models. However, for decades only bulk and surface measurements (e.g., velocimetry and reflectivity) were available to the community, and data interpretation was mainly done relying on conventional plasticity models and drawing parallels with results obtained under quasi-hydrostatic conditions. In recent years the advent of X-ray free electron lasers has provided insight into the microscopic structure of shock-compressed matter, revealing substantial differences with static compression experiments. Information at the mesoscale was, however, still missing, and the onset and propagation of the deformation at this length-scale was only accessible using computational methods; in this paper we fill that void, providing experimental data at the relevant time- and length-scales.
Here, we combine imaging and structural characterization in situ using a nanosecond pump laser coupled with a femtosecond X-ray probe in a novel experimental configuration at the LCLS. Our data provides a comprehensive characterization of the deformation of silicon, a simple, yet highly debated, model system for high-strength materials. Information spanning the macroscopic and mesoscopic scale down to the lattice level allows us to resolve and directly visualize the nucleation and growth of the high-pressure phase for the first time, providing a temporal constraint on its kinetics. These novel insights are crucial to unambiguously determine how silicon yields under shock-compression, as they are able to connect the structural evolution at the atomic level with the complex multi-wave dynamic observed at the macroscopic scale, reliably benchmarking decade-old theoretical predictions.
Perceptual Training in Ice Hockey: Bridging the Eyes-Puck Gap using Virtual Reality
Authors: Bloechle Jean-Luc , Audiffren Julien , Sauthier Quentin , Mertenat Quentin , Waeber Yohann , Aebischer David , Bresciani Jean-Pierre 
Published: June 2024

Abstract

Background Some cognitive and perceptual determinants of sports performance can be arduous to train using conventional methods. In ice-hockey, this is the case for the players’ ability to identify the Largest Exposed Area, i.e., the goal area that is the least covered by the goaltender from a puck’s perspective. We developed a Virtual Reality (VR) application to quantify and train the players’ ability to identify the Largest Exposed Area from a wide range of shooting positions. Thirty-four professional ice-hockey players were tested. Between two test sessions, half of the players followed a specific feedback-based training (Feedback group), whereas the other players practiced without feedback (Control group).
Results For the players of the Feedback group, performance was significantly better after training, whereas it remained unaltered for the players of the Control group. For both groups, performance decreased as the amplitude of the Eyes-Puck difference (i.e., the difference of perspective between the eyes and the puck) increased. This relationship vanished after training for the Feedback group but not for the Control group.
Conclusions We took advantage of VR technology to assess and train the perceptual ability to identify the Largest Exposed Area from a puck’s perspective, which would be difficult using traditional methods. Only 15 minutes of specific feedback-based training significantly and substantially improved the performance of professional ice-hockey players, thereby evidencing the efficacy of our training application.
Cerebellar Re-Irradiation after whole brain radiotherapy Significant Symptom Relief with Minimal Toxicity in Metastatic Brain Patients
Authors: haisraely ory , Jaffe Marcia , Lawerence Yaacov , Talianksy Alicia 
Published: June 2024

Abstract

Introduction Whole-brain irradiation (WBRT) remains a standard treatment for patients with extensive brain metastases, providing symptom relief and prolonging survival. However, patients often experience recurrent metastases, necessitating re-irradiation. This study evaluates the efficacy and safety of cerebellar-only re-irradiation for improving symptoms and reducing toxicity in patients with recurrent cerebellar metastases following WBRT.Methods A retrospective review was conducted on patients who underwent cerebellar re-irradiation between 2017 and 2023 after prior WBRT for symptomatic cerebellar metastases. Clinical, dosimetric, and outcome data were collected. Symptom improvement was assessed based on patient, caregiver, and physician reports three months post-treatment.Results The study included 56 patients with a median age of 53 years. Symptom domains included gait dysfunction, nausea/vomiting, dysarthria, movement disorder, dizziness, and headache. Breast cancer was the most common histology. The median interval from WBRT to cerebellar re-irradiation was 15 months. Symptomatic improvement was observed in 75% of patients, with notable improvements in nausea/vomiting (84.6%) and headache (80%). Age, dose deliver and time from WBRT were significant for clinical improvement. Dexamethasone use decreased in 76.3% of patients post-treatment. Radiological responses correlated with clinical improvements in 90% of cases. Only one patient developed symptomatic radiation necrosis. Six-month overall survival and progression-free survival were 50% and 39.2%, respectively.Conclusion Cerebellar-only re-irradiation is an effective and safe option for managing recurrent cerebellar metastases, significantly improving symptoms with minimal toxicity. This approach also allows for subsequent systemic therapy or radiosurgery for supratentorial lesions, potentially reducing the need for additional WBRT. Further studies are required to validate these findings in larger cohorts.
Differential response to preoperative exercise training in patients candidates to cardiac valve replacement
Authors: López-Hernández Antonio , Gimeno-Santos Elena , Navarro-Ripoll Ricard , Arguis Mª José , Romano Bárbara , López-Baamonde Manuel , Teres Silvia , Garza María Sanz-de la , Martínez-Palli Graciela 
Published: June 2024

Abstract

Background
There is lack of evidence regarding safety, effectiveness and applicability of prehabilitation on cardiac surgery population, particularly in patients candidates to cardiac valve replacement. The aim of the study is to assess the effect of a multimodal prehabilitation program on functional capacity in patients with severe aortic stenosis (AoS) and severe mitral regurgitation (MR) proposed for valve replacement surgery.
Methods
Secondary analysis from a randomised controlled trial whose main objective was to analyze the efficacy of a 4–6 weeks multimodal prehabilitation program in cardiac surgery on reducing postoperative complications. For this secondary analysis, only candidates for valve replacement surgery were selected. The primary outcome was the change in endurance time (ET) from baseline to preoperative assessment measured by a cycling constant work-rate cardiopulmonary exercise test.
Results
68 patients were included in this secondary analysis, 34 (20 AoS and 14 MR) were allocated to the prehabilitation group and 34 (20 AoS and 14 MR) to control group. At baseline, patients with AoS had better left systolic ventricular function and lower prevalence of atrial fibrillation compared to MR (p = 0.022 and p = 0.035 respectively). After prehabilitation program, patients with MR showed greater improvement in ET than AoS patients (101% vs. 66% increase from baseline). No adverse events related to the prehabilitation program were observed.
Conclusions
A 4–6 week exercise training program is safe and overall improves functional capacity in patients with severe AoS and MR. However, exercise response is different according to the cardiac valve type disfunction, and further studies are needed to know the factors that predispose some patients to have better training response.
Trial Registration:
The study has been registered on the Registry of National Institutes of Health ClinicalTrials.gov (NCT03466606) (March 2018).
Progressive developmental cues from multiple cardiac cell types promote cardiomyocyte maturation
Authors: Ogle Brenda , Givens Sophie , Andebrhan Abygail , Wang Ruchen , Kong Xiangzhen , Rothermel Taylor , Hosseini Sanaz , Xi An , Shameen Mohammed , Torniainen Andrea , Boland Samuel , Johnson Maya , Mancipe Natalia , Singh Bhairab , Dudley Samuel , Alford Patrick , Tolkacheva Elena , Berlo Jop van 
Published: June 2024

Abstract

Accumulating evidence in vitro indicates that the exposure of human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CM) to adult post-natal environmental conditions is not sufficient to attain maturation. Here we instead mimic the progressive embryonic ventricular environment via co-culture of hiPSC-CM with epicardial cells and epicardial-derived cells in two-dimensional (2D) direct co-culture and 3D engineered heart tissues (EHT). When epicardial cells were combined with CM in 2D direct co-cultures the percentage of proliferating CM increased at the same time as stark electrophysiologic improvements in calcium handling. Notably, no increase in single-cell CM force generation was observed, as determined using traction force microscopy. Single-cell transcriptomics revealed a significant shift in the bulk CM population in epicardial-CM co-cultures as characterized by more fetal-like myofilament isoforms but with enhanced pathways associated with cardiac conduction and ventricular
development. While co-culture of epicardial cells in the 3D-EHT model showed limited proliferation but a similar improvement in CM electrophysiologic function. These results indicate that certain aspects of CM maturation are enhanced, especially cardiac conduction, by epicardial cells while an embryonic phenotype is maintained (i.e., proliferation and myofilament isoforms). Next, consistent with developmental progression and the initiation of epicardial-to- mesenchymal transition (EMT), epicardial-derived fibroblasts were added to the EHTs containing epicardial cells. Interestingly, we observed significant myofilament maturation and increased force generation by more than an order of magnitude. Taken together, our results support the importance of mimicking developmental progression to slowly taper proliferation while gradually driving the maturation of hiPSC-CM to achieve robust in vitro function at the cell and tissue scale.
Paper-based Colorimetric Assay: Rapid Detection of HVA in Urine Samples
Authors: Bhalchim Vrushali , Undale Vaishali , Shewale Sunil 
Published: June 2024

Abstract

Diagnosing and monitoring of Parkinson's disease, schizophrenia, and certain mood disorders involves detecting homovanillic acid an essential aspect excreted through urine. In this study, we explored novel approaches for detecting homovanillic acid (HVA) in urine samples, aiming for cost-effective and on-site analysis methods. Traditional techniques like spectrophotometric determination and HPLC, while sensitive and selective, are often impractical due to their expense and lack of portability. Instead, we investigated the utility of paper-based analytical devices (PADs), which have gained popularity for various analytical applications including chemical element identification and environmental contamination assessment. We utilized different types of Whatmann filter papers (No. 1, No. 2, No. 4) and chromatography paper as substrates for the PADs, and employed combination of potassium ferrocyanide and ferric chloride reagent for HVA detection. Our experiments revealed positive results, indicating the efficacy of this approach. Optimization experiments identified 30 minutes to 3 hours as the optimal immersion times, with a subsequent 30-minute drying period at room temperature. Notably, variations in performance were observed among the different filter papers, with Whatmann CF6 paper exhibiting significant differences compared to the others in terms of HVA detection efficiency.