bluuebunny/crossref_metadata_2025_split huggingface dataset:
Linking artificial sweetener intake with kidney function: insights from NHANES 2003–2006 and findings from Mendelian randomization research
Authors: Ran Zhuoling , Zheng Yuxuan , Yu Lin , Zhang Yuxian , Zhang Zhenjiang , Li Huijie , Li Xuhan , Song Jing , Zhang Li , Zhang Ran , Lu Chang , Gong Yang , Gong Jian 
Published: May 2024

BackgroundThe current investigation examines the association between artificial sweetener (AS) consumption and the likelihood of developing chronic kidney disease (CKD), along with its impact on kidney function.MethodsWe utilized data from the National Health and Nutrition Examination Survey from 2003–2006 to conduct covariance analysis and weighted adjusted logistic regression, aiming to assess the association between artificial sweetener intake and CKD risk, as well as kidney function indicators. Subsequently, we employed Mendelian randomization methods to validate the causal relationship between the intake of artificial sweeteners, CKD risk, and kidney function indicators. Instrumental variable analysis using inverse-variance weighting and Robust adjusted profile score were the primary analytical methods employed.ResultsA total of 20,470 participants were included in the study, with 1,257 participants ultimately included in the analysis. In all adjusted logistic regression models, no significant association was found between the intake of artificial sweeteners and CKD risk. Similarly, the summary odds ratios (OR) for each unit change in genetically predicted CKD risk were 2.14 (95% CI: 0.83, 5.21, p = 0.092), 1.41 (95% CI: 0.54, 3.63, p = 0.482), and 1.50 (95% CI: 0.50, 4.52, p = 0.468) for the impact of artificial sweeteners added to cereals, tea, and coffee, respectively. It was only observed that adding artificial sweeteners to coffee was associated with a modest reduction in urinary albumin-to-creatinine ratio (OR = 0.94, 95% CI: −0.108, −0.022, p = 0.003), the effect appeared to be relatively small and may not directly impact the individual level.ConclusionOur study does not support a causal relationship between artificial sweetener intake and the risk of CKD. However, due to the limitations and potential confounding factors, these findings need to be further validated through larger sample sizes in observational studies and Mendelian randomization analyses.
High salt diet alleviates disease severity in native experimental autoimmune uveitis
Authors: Derluyn Naomi , Foucart Vincent , Verce Marko , Abdo Rami , Vaudoisey Louis , Lipski Deborah , Flamand Véronique , Everard Amandine , Bruyns Catherine , Willermain François 
Published: May 2024

BackgroundRecent studies reported a link between high salt diet (HSD) and clinical exacerbation in mouse models of autoimmune diseases, mainly through the induction of pathogenic Th17 cells and/or HSD-induced dysbiosis. However, the topic remains controversial and not fully understood.PurposeIn this study, we investigated the effects of HSD on the development of experimental autoimmune uveitis (EAU) in C57BL/6J mice.Methods and resultsUnexpectedly, our data showed a significant attenuating effect of HSD on disease severity of native EAU, induced by direct immunization with IRBP peptide. That said, HSD had no effect on EAU disease severity induced by adoptive transfer of semi-purified auto-reactive IRBP-specific T lymphocytes. Accordingly, HSD did not affect IRBP-specific systemic afferent immune response as attested by no HSD-linked changes in T lymphocytes proliferation, cytokine production and Treg proportion. Gut microbiota analysis from cecal samples in naïve and EAU mice demonstrated that HSD affected differentially α-diversity between groups, whereas β-diversity was significantly modified in all groups. Unknown Tannerellaceae was the only taxon associated to HSD exposure in all treatment groups. Interestingly, a significantly higher abundance of unknown Gastranaerophilales, with potential anti-inflammatory properties, appeared in HSD-fed native EAU mice, only.DiscussionIn conclusion, our study suggests a possible impact of HSD on gut microbiota composition and consequently on development and clinical severity of EAU. Further studies are required to investigate the potential beneficial role of Gastranaerophilales in EAU.
Predictors of neonatal near-misses in Worabe Comprehensive Specialized Hospital, Southern Ethiopia
Authors: Yasin Shemsu , Abdisa Lemesa , Roba Hirbo Shore , Tura Abera Kenay 
Published: May 2024

BackgroundNeonatal deaths are still a major leading cause of social and economic crises. Identifying neonatal near-miss events and identifying their predictors is crucial to developing comprehensive and pertinent strategies to alleviate neonatal morbidity and death. However, neither neonatal near-miss events nor their predictors were analyzed in the study area. Therefore, this study is aimed at assessing the predictors of neonatal near-misses among neonates born at Worabe Comprehensive Specialized Hospital, Southern Ethiopia, in 2021MethodsA hospital-based unmatched case-control study was conducted from 10 November 2021 to 30 November 2021. A pre-tested, structured, and standard abstraction checklist was used to collect the data. After checking the data for completeness and consistency, it was coded and entered into Epi-Data 3.1 and then exported to Stata version 14 for analysis. All independent variables with a p-value ≤0.25 in bivariable binary logistic regression were entered into a multivariable analysis to control the confounding. Variables with p-values &lt;0.05 were considered statistically significant.ResultsIn this study, 134 neonatal near-miss cases and 268 controls were involved. The identified predictors of neonatal near-misses were rural residence [adjusted odds ratio (AOR): 2.01; 95% confidence interval (CI): 1.31–5.84], no antenatal care (ANC) follow-up visits (AOR: 2.98; 95% CI: 1.77–5.56), antepartum hemorrhage (AOR: 2.12; 95% CI: 1.18–4.07), premature rupture of the membrane (AOR: 2.55; 95% CI: 1.54–5.67), and non-vertex fetal presentation (AOR: 3.05; 95% CI: 1.93–5.42).ConclusionThe current study identified rural residents, no ANC visits, antepartum hemorrhage, premature rupture of membrane, and non-vertex fetal presentation as being significantly associated with neonatal near-miss cases. As a result, local health planners and healthcare practitioners must collaborate in enhancing maternal healthcare services, focusing specifically on the early identification of issues and appropriate treatment.
A mild phenotype associated with KCNQ1 p.V205M mediated long QT syndrome in First Nations children of Northern British Columbia: effect of additional variants and considerations for management
Authors: Bene Watts Simona , Gauthier Barbara , Erickson Anders C. , Morrison Julie , Sebastian Mavis , Gillman Lawrence , McIntosh Sarah , Ens Connie , Sherwin Elizabeth , McCormick Rod , Sanatani Shubhayan , Arbour Laura 
Published: May 2024

IntroductionCongenital Long QT Syndrome (LQTS) is common in a First Nations community in Northern British Columbia due to the founder variant KCNQ1 p.V205M. Although well characterized molecularly and clinically in adults, no data have been previously reported on the pediatric population. The phenotype in adults has been shown to be modified by a splice site variant in KCNQ1 (p.L353L). The CPT1A p.P479L metabolic variant, also common in Northern Indigenous populations, is associated with hypoglycemia and infant death. Since hypoglycemia can affect the corrected QT interval (QTc) and may confer risk for seizures (also associated with LQTS), we sought to determine the effect of all three variants on the LQTS phenotype in children within our First Nations cohort.MethodsAs part of a larger study assessing those with LQTS and their relatives in a Northern BC First Nation, we assessed those entering the study from birth to age 18 years. We compared the corrected peak QTc and potential cardiac events (syncope/seizures) of 186 children from birth to 18 years, with and without the KCNQ1 (p.V205M and p.L353L) and CPT1A variants, alone and in combination. Linear and logistic regression and student t-tests were applied as appropriate.ResultsOnly the KCNQ1 p.V205M variant conferred a significant increase in peak QTc 23.8 ms (p &lt; 0.001) above baseline, with females increased by 30.1 ms (p &lt; 0.001) and males by 18.9 ms (p &lt; 0.01). There was no evidence of interaction effects with the other two variants studied. Although the p.V205M variant was not significantly associated with syncope/seizures, the odds of having a seizure/syncope were significantly increased for those homozygous for CPT1A p.P479L compared to homozygous wild type (Odds Ratio [OR]3.0 [95% confidence interval (CI) 1.2–7.7]; p = 0.019).ConclusionWhile the KCNQ1 p.V205M variant prolongs the peak QTc, especially in females, the CPT1A p.P479L variant is more strongly associated with loss of consciousness events. These findings suggest that effect of the KCNQ1 p.V205M variant is mild in this cohort, which may have implications for standard management. Our findings also suggest the CPT1A p.P479L variant is a risk factor for seizures and possibly syncope, which may mimic a long QT phenotype.
Safety classification of herbal medicine use among hypertensive patients: a systematic review and meta-analysis
Authors: Choi Dain , Im Hyea Bin , Choi Soo Jeung , Han Dongwoon 
Published: May 2024

BackgroundThe use of herbal medicines (HMs) for the treatment of hypertension (HTN) is increasing globally, but research on the potential adverse effects and safety of HMs in HTN patients is limited. Therefore, this systematic review and meta-analysis aim to determine the global prevalence of HM usage among HTN patients and assess the safety of identified herbs based on current scientific evidence.MethodsThe PubMed/MEDLINE, EMBASE (Ovid), and Cumulated Index to Nursing and Allied Health Literature (CINAHL) databases were searched for cross-sectional studies on the use of HM among HTN patients. Our review includes studies published in English up to the year 2023. After extracting and appraising the data from the studies, a meta-analysis was conducted using the Stata version 16.0 to estimate the pooled prevalence of HM use in patients with HTN (PROSPERO: CRD42023405537). The safety classification of the identified HM was done based on the existing scientific literature.ResultsThis study analyzed 37 cross-sectional studies from 21 countries and found that 37.8% of HTN patients used HM to manage their health. The prevalence of HM use varied significantly based on publication year and geographical region. Among the 71 identified herbs, Allium sativum L., Hibiscus sabdariffa L., and Olea europaea L. were the most commonly used. However, four herbs were identified as contraindicated, 50 herbs required caution, and only 11 herbs were considered safe for use.ConclusionThe study highlights the potential risks of toxicities and adverse effects associated with HM use in the treatment of HTN. Ensuring patient safety involves using safe HMs in appropriate doses and avoiding contraindicated HMs. Future research should focus on identifying commonly used herbs, especially in resource-limited countries with poor HTN management, and additional clinical research is required to assess the toxicity and safety of commonly used HMs.
Impacts of farming activities on carbon deposition based on fine soil subtype classification
Authors: Wang Qiuju , Zhang Dongdong , Jiao Feng , Zhang Haibin , Guo Zhenhua 
Published: May 2024

IntroductionSoil has the highest carbon sink storage in terrestrial ecosystems but human farming activities affect soil carbon deposition. In this study, land cultivated for 70 years was selected. The premise of the experiment was that the soil could be finely categorized by subtype classification. We consider that farming activities affect the soil bacterial community and soil organic carbon (SOC) deposition differently in the three subtypes of albic black soils.MethodsNinety soil samples were collected and the soil bacterial community structure was analysed by high-throughput sequencing. Relative changes in SOC were explored and SOC content was analysed in association with bacterial concentrations. ResultsThe results showed that the effects of farming activities on SOC deposition and soil bacterial communities differed among the soil subtypes. Carbohydrate organic carbon (COC) concentrations were significantly higher in the gleying subtype than in the typical and meadow subtypes. RB41, Candidatus-Omnitrophus and Ahniella were positively correlated with total organic carbon (TOC) in gleying shallow albic black soil. Corn soybean rotation have a positive effect on the deposition of soil carbon sinks in terrestrial ecosystems.DiscussionThe results of the present study provide a reference for rational land use to maintain sustainable development and also for the carbon cycle of the earth.
From personification abuse to normal expression: emotional treatment for language disorders in schools
Authors: Ke Yuguo , Zhou Xiaozhen 
Published: May 2024

IntroductionThe escalating prevalence of personification abuse in language disorders among students poses a substantial challenge for autistic students in the domain of language disorders. While prior research has mainly focused on the cognitive hurdles faced by autistic students, ongoing debates persist about the onset, severity, and roots of these challenges in their classroom behavior, with limited exploration of how preconceived notions impact personification abuse. This study aims to delve into emotional treatments for language disorders, specifically targeting personification abuse, to facilitate the shift from distorted perceptions to normative expression. It seeks to pinpoint the primary emotional interventions linked to instances of personification abuse and scrutinize the emotional factors influencing therapeutic approaches for language disorders.MethodsThe research encompassed a cohort of 110 autistic students, aged 2 to 5 years, diagnosed with language disorders, all clinically determined to have autism by developmental pediatricians at a prestigious medical facility. Among these children, 95 were attending specialized schools, while 15 were situated in community settings.ResultsThe outcomes disclosed that children across all developmental phases displayed instances of personification abuse in language disorders, showcasing noteworthy enhancements in personification abuse following emotional treatment. Significantly, the discernible disparity in personification abuse performance and emotional treatment can be linked to the simultaneous cognitive advancement of autistic students across four grade levels, with variations noted based on normative expressions.DiscussionThese findings underscore the insufficiency of solely relying on intrinsic trends to comprehend personification abuse within an emotional treatment context. The study accentuates the potential pitfalls associated with emotional treatment for language disorders and stresses the imperative need for additional research and psychiatric intervention strategies.
Resilience of mental health services amidst Ebola disease outbreaks in Africa
Authors: Wirsiy Frankline Sevidzem , Tahmo Nancy B. , Tatah Lambed , Brett-Major David M. 
Published: May 2024

IntroductionHealth systems including mental health (MH) systems are resilient if they protect human life and produce better health outcomes for all during disease outbreaks or epidemics like Ebola disease and their aftermaths. We explored the resilience of MH services amidst Ebola disease outbreaks in Africa; specifically, to (i) describe the pre-, during-, and post-Ebola disease outbreak MH systems in African countries that have experienced Ebola disease outbreaks, (ii) determine the prevalence of three high burden MH disorders and how those prevalences interact with Ebola disease outbreaks, and, (iii) describe the resilience of MH systems in the context of these outbreaks.MethodsThis was a scoping review employing an adapted PRISMA statement. We conducted a five-step Boolean strategy with both free text and Medical Subject Headings (MeSH) to search 9 electronic databases and also searched WHO MINDbank and MH Atlas.ResultsThe literature search yielded 1,230 publications. Twenty-five studies were included involving 13,449 participants. By 2023, 13 African nations had encountered a total of 35 Ebola outbreak events. None of these countries had a metric recorded in MH Atlas to assess the inclusion of MH in emergency plans. The three highest-burden outbreak-associated MH disorders under the MH and Psychosocial Support (MHPSS) framework were depression, post-traumatic stress disorder (PTSD), and anxiety with prevalence ranges of 1.4–7%, 2–90%, and 1.3–88%, respectively. Furthermore, our analysis revealed a concerning lack of resilience within the MH systems, as evidenced by the absence of pre-existing metrics to gauge MH preparedness in emergency plans. Additionally, none of the studies evaluated the resilience of MH services for individuals with pre-existing needs or examined potential post-outbreak degradation in core MH services.DiscussionOur findings revealed an insufficiency of resilience, with no evaluation of services for individuals with pre-existing needs or post-outbreak degradation in core MH services. Strengthening MH resilience guided by evidence-based frameworks must be a priority to mitigate the long-term impacts of epidemics on mental well-being.
Towards an understanding of maltreatment in football
Authors: Newman James A. , Rumbold James L. 
Published: May 2024

IntroductionThis study explored the understanding of maltreatment from the perspective of various personnel working in roles related to safeguarding and welfare in English professional and semi-professional football.MethodThrough a social constructivist position, the present study was able to explore multiple understandings and perceptions of maltreatment in football. Individual semi-structured interviews (MDuration = 68.00 minutes, SD = 9.05 minutes) were conducted with 19 participants working across league structures ranging from the English Premier League (EPL) to the English Northern Premier League Division One, as well as individuals working with some of the principal organizations in English professional football.ResultsThrough reflexive thematic analysis, three general dimensions were highlighted: “current understanding of maltreatment in football,” “constituents of maltreatment,” and “signs and symptoms of maltreatment.” Findings from those working in a safeguarding capacity mirror the research literature around understanding the components of maltreatment but also demonstrate how wrongdoing is nuanced by the football context, in that certain forms of maltreatment are driven by the unique nature of this environment.DiscussionFrom an applied perspective, the findings also outline how to distinguish both the more overt and covert signs and symptoms of maltreatment, whilst also highlighting the impact of maltreatment on individuals' mental health and their sense of self. Overall, the findings provide a platform for practitioners and researchers to consider in the design of safeguarding and welfare provision by highlighting the need to raise knowledge and awareness of maltreatment whilst intervening to challenge the prevailing workplace culture within professional football.
A Transcriptome Response of Bread Wheat (Triticum aestivum L.) to a 5B Chromosome Substitution from Wild Emmer
Authors: Muterko Alexandr , Kiseleva Antonina , Salina Elena 
Published: May 2024

Over the years, alien chromosome substitution has attracted the attention of geneticists and breeders as a rich source of remarkable genetic diversity for improvement in narrowly adapted wheat cultivars. One of the problems encountered along this way is the coadaptation and realization of the genome of common wheat against the background of the introduced genes. Here, using RNA-Seq, we assessed a transcriptome response of hexaploid wheat Triticum aestivum L. (cultivar Chinese Spring) to a 5B chromosome substitution with its homolog from wild emmer (tetraploid wheat T. dicoccoides Koern) and discuss how complete the physiological compensation for this alien chromatin introgression is. The main signature of the transcriptome in the substituted line was a sharp significant drop of activity before the beginning of the photoperiod with a gradual increase up to overexpression in the middle of the night. The differential expression altered almost all biological processes and pathways tested. Because in most cases, the differential expression or its fold change were modest, and this was only a small proportion of the expressed transcriptome, the physiological compensation of the 5B chromosome substitution in common wheat seemed overall satisfactory, albeit not completely. No over- or under-representation of differential gene expression was found in specific chromosomes, implying that local structural changes in the genome can trigger a global transcriptome response.
الوسائل البديلة في القانون الفرنسي «MARC» من التخيير إلى الإلزام (دراسة تحليلية للقانون رقم 1333-2019 بإضافة المادة 1-750 لقانون الإجراءات المدنية الفرنسي)
Authors: خمان سماح 
Published: May 2024

الأهداف: يهدف هذا البحث إلى دراسة موقف المشرع الفرنسي الجديد من الوسائل الودية لتسوية المنازعات والذي انتقل بشأنها من فكرة الترغيب والتحفيز على اللجوء إليها، إلى مبدأ الإلزام وجعلها طريقاً إجبارياً يتعين على المتقاضين سلوكه قبل قيد صحيفة الدعوى، بل، ويترتب على عدم الالتزام بذلك توقيع جزاء عدم قبول الدعوى القضائية. المنهج: اعتمدت الدراسة المنهج التحليلي لدراسة وتحليل نصوص القانون الفرنسي الموجودة والمستحدثة بشأن الوسائل البديلة، مع عرض لآراء الفقه الفرنسي تجاه التعديلات الأخيرة. النتائج: يمكن تلخيص أبرز ما توصلت إليه الدراسة فيما يلي: 1- لا يُغني التحكيم اليوم ولا القضاء عن وجوب البحث عن وسائل تسوية جديدة للمنازعات التي تشهد تضخماً غير مسبوق في جميع أنحاء العالم. 2- مر المشرع الفرنسي بعدة مراحل تجاه إقرار وإلغاء اللجوء إلى الوسائل الودية. 3- عزوف القضاة عن استخدام صلاحية التوفيق التي منحتها لهم المادة 21 من قانون الإجراءات المدنية، والكم الهائل من الملفات المتراكمة أمام موفقي العدالة قد دفعت المشرع لإلغاء التوفيق الإجباري بسبب عدم كفاية الأدوات اللازمة لتفعيله لا بسبب عدم فعاليته. 3- بعد أن تفاقمت إشكالية بطء التقاضي في المحاكم الفرنسية، توجه المشرع مرة أخرى لفكرة اللجوء الإجباري -لا للتوفيق وحده- ولكن لجميع الوسائل البديلة المتاحة، بحيث تكمل كل وسيلة الأخرى وتتلافى عيوبها. الخاتمة: خلصت الدراسة إلى التوصية بتعديل نصوص قوانين المرافعات لفرض اللجوء إلى الوسائل البديلة قبل رفع الدعوى القضائية على غرار المشرع الفرنسي لتحقيق العدالة المنجزة، والحد من مشكلة بطء التقاضي في الدول العربية.
The Impact of the Online Learning Readiness Self-Check Survey with Australian Tertiary Enabling Students
Authors: Whannell Robert , Parkes Mitchell , Bartlett-Taylor Tim , Harrington Ingrid 
Published: May 2024

This study reports on two key aspects relating to the use of the Online Learning Readiness Self-Check (OLRSC) survey, which has been proposed as identifying non-traditional students’ readiness for online learning, and their strengths and weaknesses in six key areas. The first aspect validates the use of the instrument based on data from 199 students engaged in an online tertiary enabling course at a regional university in Australia. Factor analysis verified the scale structure of the instrument; however, two items were removed prior to the final analysis due to low communality and/or high cross loading with other items. This is followed by an examination of whether the instrument might be useful for the early identification of students who are at risk of disengagement from the enabling program. While it was hypothesised that the instrument, which measured factors such as the quality of interaction with peers and instructors, their capacity to manage technology and how well they managed learning, should have been a useful tool to identify early disengagement, the hypothesis was not supported. No significant associations were identified between any of the instrument’s scales and early withdrawal from the course or completion of the first unit of study. Future recommendations for educators are made with a view to improving student engagement.