bluuebunny/crossref_metadata_2025_split huggingface dataset:
Bifurcation analysis and new waveforms to the first fractional WBBM equation
Authors: Ullah Mohammad Safi , Ali M. Zulfikar , Roshid Harun-Or 
Published: May 2024

AbstractThis research focuses on bifurcation analysis and new waveforms for the first fractional 3D Wazwaz–Benjamin–Bona–Mahony (WBBM) structure, which arises in shallow water waves. The linear stability technique is also employed to assess the stability of the mentioned model. The suggested equation’s dynamical system is obtained by applying the Galilean transformation to achieve our goal. Subsequently, bifurcation, chaos, and sensitivity analysis of the mentioned model are conducted by applying the principles of the planar dynamical system. We obtain periodic, quasi-periodic, and chaotic behaviors of the mentioned model. Furthermore, we introduce and delve into diverse solitary wave solutions, encompassing bright soliton, dark soliton, kink wave, periodic waves, and anti-kink waves. These solutions are visually presented through simulations, highlighting their distinct characteristics and existence. The results highlight the effectiveness, brevity, and efficiency of the employed integration methods. They also suggest their applicability to delving into more intricate nonlinear models emerging in modern science and engineering scenarios. The novelty of this research lies in its detailed analysis of the governing model, which provides insights into its complex dynamics and varied wave structures. This study also advances the understanding of nonlinear wave properties in shallow water by combining bifurcation analysis, chaotic behavior, waveform characteristics, and stability assessments.
Preferences for and intention to use an app for premenstrual mental health symptoms using the Health Behaviour Model (HBM)
Authors: Funnell Erin L. , Martin-Key Nayra A. , Benacek Jiri , Spadaro Benedetta , Bahn Sabine 
Published: May 2024

AbstractPremenstrual symptoms are common, with premenstrual syndrome and premenstrual dysphoric disorder associated with decreased wellbeing and increased suicidality. Apps can offer convenient support for premenstrual mental health symptoms. We aimed to understand app preferences and Health Belief Model (HBM) constructs driving app use intention. An online survey was delivered. Structural equation modelling (SEM) explored HBM constructs. Data from 530 United Kingdom based participants who reported their mental health was impacted by their menstrual cycle (mean age = 35.85, SD = 7.28) were analysed. In terms of preferred app features, results indicated that symptom monitoring (74.72%, n = 396) and psychoeducation (57.92%, n = 307) were sought after, with 52.64% (n = 279) indicating unwillingness to pay for an app for mental health symptoms related to the menstrual cycle. Regarding HBM results, Satorra–Bentler-scaled fit statistics indicated a good model fit (χ2(254) = 565.91, p < 0.001; CFI = 0.939, RMSEA = 0.048, SRMR = 0.058). HBM constructs explained 58.22% of intention to use, driven by cues to action (β = 0.49, p < 0.001), perceived barriers (β = −0.22, p < 0.001), perceived severity (β = 0.16, P = 0.012), and perceived benefits (β = 0.10, p = 0.035). Results indicate that app developers should undertake co-design, secure healthcare professional endorsement, highlight therapeutic benefits, and address barriers like digital discomfort, privacy concerns, and quality.
Is endothelin targeting finally ready for prime time?
Authors: Schinzari Francesca , Tesauro Manfredi , Cardillo Carmine 
Published: May 2024

Abstract
The endothelin family of peptides has long been recognized as a physiological regulator of diverse biological functions and mechanistically involved in various disease states, encompassing, among others, the cardiovascular system, the kidney, and the nervous system. Pharmacological blockade of the endothelin system, however, has encountered strong obstacles in its entry into the clinical mainstream, having obtained only a few proven indications until recently. This translational gap has been attributable predominantly to the relevant side effects associated with endothelin receptor antagonism (ERA), particularly fluid retention. Of recent, however, an expanding understanding of the pathophysiological processes involving endothelin, in conjunction with the development of new antagonists of endothelin receptors or adjustment of their doses, has driven a flourish of new clinical trials. The favorable results of some of them have extended the proven indications for ET targeting to a variety of clinical conditions, including resistant arterial hypertension and glomerulopathies. In addition, on the ground of strong preclinical evidence, other studies are ongoing to test the potential benefits of ERA in combination with other treatments, such as sodium-glucose co-transporter 2 inhibition in fluid retentive states or anti-cancer therapies in solid tumors. Furthermore, antibodies providing long-term blockade of endothelin receptors are under testing to overcome the short half-life of most small molecule endothelin antagonists. These efforts may yet bring new life to the translation of endothelin targeting strategies in clinical practice.
New SiS destruction and formation routes via neutral-neutral reactions and their fundamental role in interstellar clouds at low- and high-metallicity values
Authors: Mendoza Edgar , Costa Samuel F. M. , Carvajal Miguel , Pilling Sérgio , Alves Márcio O. , Galvão Breno R. L. 
Published: May 2024

Context. Among the silicon-bearing species discovered in the interstellar medium, SiS and SiO stand out as key tracers due to their distinct chemistry and variable abundances in interstellar and circumstellar environments. Nevertheless, while the origins of SiO are well documented, the SiS chemistry remains relatively unexplored.
Aims. Our objective is to enhance the network of Si- and S-bearing chemical reactions for a gas-grain model in molecular clouds, encompassing both low and high metallicities. To achieve this, we calculated the energies and rate coefficients for six neutral atom-diatom reactions involved in the SiCS triatomic system, with a special focus on the C+SiS and S+SiC collisions.
Methods. We employed the coupled-cluster method with single and double substitutions and a perturbative treatment of triple substitutions (CCSD(T)) refined at the explicitly correlated CCSD(T)-F12 level. With these computational results in conjunction with supplementary data from the literature, we construct an extended network of neutral-neutral chemical reactions involving Si- and S-bearing molecules. To assess the impact of these chemical reactions, we performed time-dependent models employing the Nautilus gas-grain code, setting the gas temperature to 10 K and the H2 density to 2 × 104 cm−3. The models considered two initial abundance scenarios, corresponding to low- and high-metallicity levels. Abundances were computed using both the default chemical network and the constrained network, enriched with newly calculated reactions.
Results. The temperature dependence for the reactions involving SiS were modelled to the k(T) = α (T/300)β exp (−γ/T) expression, and the coefficients are provided for the first time. The high-metallicity models significantly boost the SiS production, resulting in abundances nearly four orders of magnitude higher compared to low-metallicity models. Higher initial abundances of C, S, and Si, roughly ~2, 190, and 210 times higher, respectively, contribute to this. Around the age of 103 yr, destruction mechanisms become relevant, impacting the abundance of SiS. The proposed production reaction S + SiC → C + SiS, mitigates these effects in later stages. By expanding the gas reaction network using a high-metallicity model, we derived estimates for the abundances of observed interstellar molecules, including SiO, SO, and SO2.
Conclusions. We demonstrate the significance of both SiC+S and C+SiS channels in the SiS chemistry. Notably, the inclusion of neutral-neutral mechanisms, particularly via Si+HS and S+SiC channels, played a pivotal role in determining SiS abundance. These mechanisms carry a significance level on a par with that of the well-known and fast ion-neutral reactions.
Pulmonale Hypertonie bei Erwachsenen mit angeborenen Herzfehlern im Lichte der 2022-ESC-PAH-Leitlinien
Authors: Kaemmerer Harald , Diller Gerhard Paul , Achenbach Stephan , Dähnert Ingo , Eichstaedt Christina A. , Eicken Andreas , Freiberger Annika , Freilinger Sebastian , Geiger Ralf , Gorenflo Matthias , Grünig Ekkehard , Hager Alfred , Huntgeburth Michael , Kaemmerer-Suleiman Ann-Sophie , Kozlik-Feldmann Rainer , Lammers Astrid E. , Nagdyman Nicole , Michel Sebastian , Schmidt Kai Helge , Uebing Anselm , von Scheidt Fabian , Apitz Christian 
Published: May 2024

ZusammenfassungDie Zahl der Erwachsenen mit angeborenen Herzfehlern (AHF) steigt ständig und liegt in Deutschland bei etwa 360 000. AHF sind häufig mit einer pulmonalen Hypertonie (PH) assoziiert, die sich bei unbehandelten AHF teils schon frühzeitig entwickeln. Trotz einer zeitgerechten Behandlung des AHF persistiert eine PH häufig oder entwickelt sich im höheren Lebensalter neu und ist mit erheblicher Morbidität und Letalität behaftet.Die überarbeiteten Leitlinien (LL) der European Society of Cardiology/European Respiratory Society 2022 für die Diagnostik und Behandlung der PH stellen einen wesentlichen Beitrag zur optimierten Versorgung der Betroffenen dar. Der Themenbereich „Erwachsene mit angeborenen Herzfehlern“ wird in diesem Zusammenhang allerdings nur relativ oberflächlich behandelt. In dem vorliegenden Artikel wird diese Thematik daher detailliert aus Sicht der kongenitalen Kardiologie kommentiert.
The LAT Rheostat as a Regulator of Megakaryocyte Activation
Authors: Moroi Alyssa J. , Newman Peter J. 
Published: May 2024

Background Specifically positioned negatively charged residues within the cytoplasmic domain of the adaptor protein, linker for the activation of T cells (LAT), have been shown to be important for efficient phosphorylation of tyrosine residues that function to recruit cytosolic proteins downstream of immunoreceptor tyrosine-based activation motif (ITAM) receptor signaling. LAT tyrosine 132—the binding site for PLC-γ2—is a notable exception, preceded instead by a glycine, making it a relatively poor substrate for phosphorylation. Mutating Gly131 to an acidic residue has been shown in T cells to enhance ITAM-linked receptor-mediated signaling. Whether this is generally true in other cell types is not known.
Methods To examine whether LAT Gly131 restricts ITAM signaling in cells of the megakaryocyte lineage, we introduced an aspartic acid at this position in human induced pluripotent stem cells (iPSCs), differentiated them into megakaryocytes, and examined its functional consequences.
Results iPSCs expressing G131D LAT differentiated and matured into megakaryocytes normally, but exhibited markedly enhanced reactivity to glycoprotein VI (GPVI)-agonist stimulation. The rate and extent of LAT Tyr132 and PLC-γ2 phosphorylation, and proplatelet formation on GPVI-reactive substrates, were also enhanced.
Conclusion These data demonstrate that a glycine residue at the -1 position of LAT Tyr132 functions as a kinetic bottleneck to restrain Tyr132 phosphorylation and signaling downstream of ITAM receptor engagement in the megakaryocyte lineage. These findings may have translational applications in the burgeoning field of in vitro platelet bioengineering.
Exploring Causal Relationships between Circulating Inflammatory Proteins and Thromboangiitis Obliterans: A Mendelian Randomization Study
Authors: Zhang Bihui , He Rui , Yao Ziping , Li Pengyu , Niu Guochen , Yan Ziguang , Zou Yinghua , Tong Xiaoqiang , Yang Min 
Published: May 2024

Background Thromboangiitis obliterans (TAO) is a vascular condition characterized by poor prognosis and an unclear etiology. This study employs Mendelian randomization (MR) to investigate the causal impact of circulating inflammatory proteins on TAO.
Methods In this MR analysis, summary statistics from a genome-wide association study meta-analysis of 91 inflammation-related proteins were integrated with independently sourced TAO data from the FinnGen consortium's R10 release. Methods such as inverse variance weighting, MR–Egger regression, weighted median approaches, MR-PRESSO, and multivariable MR (MVMR) analysis were utilized.
Results The analysis indicated an association between higher levels of C–C motif chemokine 4 and a reduced risk of TAO, with an odds ratio (OR) of 0.44 (95% confidence interval [CI]: 0.29–0.67; p = 1.4 × 10−4; adjusted p = 0.013). Similarly, glial cell line-derived neurotrophic factor exhibited a suggestively protective effect against TAO (OR: 0.43, 95% CI: 0.22–0.81; p = 0.010; adjusted p = 0.218). Conversely, higher levels of C–C motif chemokine 23 were suggestively linked to an increased risk of TAO (OR: 1.88, 95% CI: 1.21–2.93; p = 0.005; adjusted p = 0.218). The sensitivity analysis and MVMR revealed no evidence of heterogeneity or pleiotropy.
Conclusion This study identifies C–C motif chemokine 4 and glial cell line-derived neurotrophic factor as potential protective biomarkers for TAO, whereas C–C motif chemokine 23 emerges as a suggestive risk marker. These findings elucidate potential causal relationships and highlight the significance of these proteins in the pathogenesis and prospective therapeutic strategies for TAO.
Optimizing Use of High-Sensitivity Troponin for Risk-Stratification of Acute Pulmonary Embolism
Authors: Goraya Sayhaan R. , O'Hare Connor , Grace Kelsey A. , Schaeffer William J. , Hyder S. Nabeel , Barnes Geoffrey D. , Greineder Colin F. 
Published: May 2024

Background High-sensitivity troponin T (HS-TnT) may improve risk-stratification in hemodynamically stable acute pulmonary embolism (PE), but an optimal strategy for combining this biomarker with clinical risk-stratification tools has not been determined.
Study Hypothesis We hypothesized that different HS-TnT cutoff values may be optimal for identifying (1) low-risk patients who may be eligible for outpatient management and (2) patients at increased risk of clinical deterioration who might benefit from advanced PE therapies.
Methods Retrospective analysis of hemodynamically stable patients in the University of Michigan acute ED-PE registry with available HS-TnT values. Primary and secondary outcomes were 30-day mortality and need for intensive care unit-level care. Receiver operating characteristic curves were used to determine optimal HS-TnT cutoffs in the entire cohort, and for those at higher risk based on the simplified Pulmonary Embolism Severity Index (PESI) or imaging findings.
Results The optimal HS-TnT cutoff in the full cohort, 12 pg/mL, was significantly associated with 30-day mortality (odds ratio [OR]: 3.94, 95% confidence interval [CI]: 1.48–10.50) and remained a significant predictor after adjusting for the simplified PESI (sPESI) score and serum creatinine (adjusted OR: 3.05, 95% CI: 1.11–8.38). A HS-TnT cutoff of 87 pg/mL was associated with 30-day mortality (OR: 5.01, 95% CI: 2.08–12.06) in patients with sPESI ≥1 or right ventricular dysfunction.
Conclusion In this retrospective, single-center study of acute PE patients, we identified distinct optimal HS-TnT values for different clinical uses—a lower cutoff, which identified low-risk patients even in the absence of other risk-stratification methods, and a higher cutoff, which was strongly associated with adverse outcomes in patients at increased risk.
Update in Pediatric Neurocritical Care: What a Neurologist Caring for Critically Ill Children Needs to Know
Authors: Plante Virginie , Basu Meera , Gettings Jennifer V. , Luchette Matthew , LaRovere Kerri L. ,   The Pediatric Critical Nervous System Program (pCNSp)
Published: May 2024

AbstractCurrently nearly one-quarter of admissions to pediatric intensive care units (PICUs) worldwide are for neurocritical care diagnoses that are associated with significant morbidity and mortality. Pediatric neurocritical care is a rapidly evolving field with unique challenges due to not only age-related responses to primary neurologic insults and their treatments but also the rarity of pediatric neurocritical care conditions at any given institution. The structure of pediatric neurocritical care services therefore is most commonly a collaborative model where critical care medicine physicians coordinate care and are supported by a multidisciplinary team of pediatric subspecialists, including neurologists. While pediatric neurocritical care lies at the intersection between critical care and the neurosciences, this narrative review focuses on the most common clinical scenarios encountered by pediatric neurologists as consultants in the PICU and synthesizes the recent evidence, best practices, and ongoing research in these cases. We provide an in-depth review of (1) the evaluation and management of abnormal movements (seizures/status epilepticus and status dystonicus); (2) acute weakness and paralysis (focusing on pediatric stroke and select pediatric neuroimmune conditions); (3) neuromonitoring modalities using a pathophysiology-driven approach; (4) neuroprotective strategies for which there is evidence (e.g., pediatric severe traumatic brain injury, post–cardiac arrest care, and ischemic stroke and hemorrhagic stroke); and (5) best practices for neuroprognostication in pediatric traumatic brain injury, cardiac arrest, and disorders of consciousness, with highlights of the 2023 updates on Brain Death/Death by Neurological Criteria. Our review of the current state of pediatric neurocritical care from the viewpoint of what a pediatric neurologist in the PICU needs to know is intended to improve knowledge for providers at the bedside with the goal of better patient care and outcomes.
Sensitive detection and imaging of H2O density through Rydberg resonant femtosecond laser induced photofragmentation fluorescence
Authors: Livingston Large Timothy A. , Kliewer Christopher J. 
Published: May 2024

A femtosecond laser induced photofragmentation fluorescence (fs-LIPF) scheme for the sensitive detection and imaging of water vapor is presented. Two photons of 244.3 nm excite water to the D̃ state and produce hydroxyl radicals in the fluorescing Ã state. Two more photons promote electrons from the D̃ state to a neutral Rydberg state of the (1b2)−1 ionic core through a 2 + 2 doubly resonant process. The resulting high-lying Rydberg state undergoes neutral dissociation, and the energetic hydrogen fragments are detected from their Balmer series fluorescence. These channels (in the low-pressure limit) have detection sensitivities around 1012 molecules per cubic centimeters, orders of magnitude more sensitive than laser-induced fluorescence based approaches, allowing for sensitive non-invasive detection and imaging of water density for many important processes.
Enhancing the circular dichroism of chiral dielectric nanostructure through the addition of a symmetric Au cylinder
Authors: Xi Feng , Hu Li , Dai Hongxia 
Published: May 2024

Abstract
Circular dichroism (CD) spectra play a crucial role in recognition, separation and detection of chiral molecules. Due to the inherent weak CD response of natural chiral molecules, researchers have endeavored to enhance CD signals through various artificial nanostructures. In this study, combining the advantages of both the dielectric and metal materials, we propose a hybrid dielectric-metal nanostructure consisting of a chiral Si nanorod dimer coupled with a symmetric Au cylinder to achieve robust CD responses. Owing to the plasmon resonance of the Au cylinder, the scattering-CD and absorption-CD of the hybrid system have been enhanced, which result in the enhanced extinction-CD response. Furthermore, the distributions of electric field, magnetic field and displacement current density of both the Si dimer and hybrid nanostructure have been meticulously crafted to elucidate the physical mechanisms underlying amplified CD signals. The synergistic coupling between the magnetic fields of dielectric materials and the electric fields of the Au cylinder leads to an increase in the electric field strength and the asymmetry of near-field distributions. Additionally, spatial overlaps between electric and magnetic fields occur. These factors contribute to the enhanced chiral response of the hybrid system. Meanwhile, the CD signal can be flexibly tuned by adjusting the size of the Au cylinder and Si nanorods. This design offers a versatile approach to enhancing the chiral response of dielectric nanostructures.
Bionic noise reduction design of axial fan impeller
Authors: Sun Yulong , Li Rui , Wang Linbo , Liu Chongrui , Yang Zhibo , Ma Fuyin 
Published: May 2024

Abstract
Fans are integral equipment widely employed in both industrial settings and daily life. However, a persistent challenge in fans design lies in the inherent conflict between aerodynamic performance and noise levels. Improving aerodynamic efficiency often results in a compromise of acoustic performance. To tackle this issue, we employed the bionic design method to craft a novel axial fan impeller featuring a bionic curved hub and bionic serrated leading edges. The impact of structural optimization on the aerodynamic and acoustic properties of the impeller, as well as the influence of optimization parameters on these properties, were systematically investigated through numerical simulations. The bionic impeller was then fabricated using 3D printing, and the aerodynamic and noise performance of the impeller were experimentally evaluated by integrating it into an external air conditioner. Comparison of the flow field and sound field data between the optimized and prototype impellers revealed noteworthy outcomes. The curved wall at the bionic hub’s tail effectively diminished the pressure gradient on the hub surface, directing the airflow toward the rear end of the hub. This design enhancement significantly reduced the turbulent area behind the prototype impeller’s hub. Additionally, under the appropriately designed, the bionic serrated structure could effectively reduce the contact area between the blade’s leading edge and incoming flow. This led to the dispersion of stress concentrations and the inhibition of strong turbulence generation. Notably, the experimental results indicated a 3.7% increase in air volume flow rate and a 2.3 dB reduction in noise for the optimized impeller compared to the prototype. This successful mitigation of the trade-off between aerodynamic performance and noise level underscores the effectiveness of our bionic design approach.