bluuebunny/crossref_metadata_2025_split huggingface dataset:
ChemInform Abstract: Synthesis of Highly Functionalized Piperidines by One‐Pot Multicomponent Reaction Using Tetrabutylammonium Tribromide (TBATB).
Authors: Khan Abu T. , Lal Mohan , Khan Md. Musawwer 
Published: November 2010

AbstractThe process allows the synthesis of moderate to good yields of the target compounds, required as synthons for natural products and bioactive substances.The method fails if α‐naphthylamine is used.
ChemInform Abstract: Microwave‐Assisted Synthesis of 3‐Cyano‐2‐(1H‐indol‐3‐yl)pyridine Derivatives by a Multicomponent Reaction.
Authors: Geng Li‐Jun , Feng Guo‐Liang , Yu Jiu‐Gao 
Published: November 2010

AbstractAdvantages of the title procedure are experimental simplicity, easy work‐up and compatibility with various functional groups.
ChemInform Abstract: Studies Toward Synthesis of Arteminolides: Intramolecular [5 + 2] Oxidopyrylium Ion Cycloaddition Reactions with Silicon Tether.
Authors: Sohn Jeong‐Hun 
Published: November 2010

AbstractCompound (III), which has the common ring skeleton of the B‐ and B′‐rings of arteminolides, is synthesized in eight steps starting from 1,3‐propanediol via an unprecedented intramolecular [5 + 2] oxidopyrylium cycloaddition reaction with vinylsilyl ether tether as key step.
ChemInform Abstract: Synthesis of Novel Organogermanium Derivative (IV) Conjugated with Vitamin C and Study of Its Antioxidant Effects.
Authors: Lim Doo Hyeon , Li Minghua , Kim Eun‐hye , Ham Seung Wook 
Published: November 2010

AbstractThe title compound (IV) is found to display better antioxidant activity than ascorbic acid.
ChemInform Abstract: Cytotoxic Sesquilignans from the Roots of Saururus chinensis
Authors: Chin Young‐Won , Cai Xing‐Fu , Ahn Kyung‐Seop , Lee Hyeong‐Kyu , Oh Sei‐Ryang 
Published: November 2010

Abstractstructure elucidation and cytotoxicity of 7′′R,8′′S‐saucernol (I) and saucerneol J (7′′R,8′′S‐configuration) (II) along with six known compounds
ChemInform Abstract: Hygrobafilomycin, a Cytotoxic and Antifungal Macrolide Bearing a Unique Monoalkylmaleic Anhydride Moiety, from Streptomyces varsoviensis.
Authors: Ndejouong Basile Le S. Tchize , Sattler Isabel , Maier Armin , Kelter Gerhard , Menzel Klaus‐Dieter , Fiebig Heinz‐Herbert , Hertweck Christian 
Published: November 2010

AbstractHygrobafilomycin (I) shows strong antifungal, antiproliferative and cytotoxic activities.
Quantitative dynamic‐memory analysis for Java
Authors: Garbervetsky Diego , Yovine Sergio , Braberman Víctor , Rouaux Martín , Taboada Alejandro 
Published: November 2010

AbstractSpace‐ and time‐predictability are hard to achieve for object‐oriented languages with automated dynamic‐memory management. Although there has been significant work to design APIs, such as the Real‐Time Specification for Java (RTSJ), and to implement garbage collectors to enable real‐time performance, quantitative space analysis is still in its infancy. This work presents the integration of a series of compile‐time analysis techniques to help predicting quantitative memory usage. In particular, we focus on providing tool assistance for identifying RTSJ scoped‐memory regions, their sizes, and overall memory usage. First, the tool‐suite synthesizes a memory organization where regions are associated with methods. Second, it infers their sizes inparametricclosed form in terms of relevant program variables. Third, it exhibits a parametric upper bound on the amount of available free memory required to execute a method. The experiments carried out with a RTSJ benchmark, a real‐time aircraft collision detector, show that semi‐automatic, tool‐assisted generation of scoped‐based code is both helpful and doable. Copyright © 2010 John Wiley & Sons, Ltd.
Ion permeation simulations by Gromacs—an example of high performance molecular dynamics
Authors: Krüger J. , Fels G. 
Published: November 2010

AbstractThe loss of inter‐neuron communication is related to many neuronal diseases such as Alzheimer's dementia. The nicotinic acetylcholine receptor (nAChR) plays a crucial role in this process and is severely affected upon disease progression. Successful therapy approaches rely on modulation of response signals, initiated by the flux of ions through the receptor integrated ion channel at the post‐synaptic membrane. We present here the comparison of two methods for calculating the energy barrier of nAChR mediated ion permeation, in terms of accuracy and performance. Detailed descriptions of archetypical Gromacs characteristics are given offering better insight into computational service providers to meet the needs of scientists. Copyright © 2010 John Wiley & Sons, Ltd.
Bayesian intelligent semantic mashup for tourism
Authors: Wang Wei , Zeng Guosun , Tang Daizhong 
Published: November 2010

AbstractA common perception is that there are two competing visions for the future evolution of the Web: the Semantic Web and Web 2.0. In fact, Semantic Web technologies must integrate with Web 2.0 services for both to leverage each other's strengths. This paper illustrates how Semantic Web technologies can support information integration and make it easy to create semantic mashups. An intelligent recommendation system for tourism is presented to show the efficiency of our method. Through the ontology of tourism, the system allows the integration of heterogeneous online travel information. An integrated knowledge process is developed to guarantee the whole engineering procedure. Based on the Bayesian network technique, the system recommends tourist attractions to a user by taking into account the travel behavior both of the user and of other users. Copyright © 2010 John Wiley & Sons, Ltd.
An accurate power delivery system (PDS) design methodology for high‐speed digital systems
Authors: Nabil Shaymaa M. , El‐Rouby Alaa B. , Khalil Ahmed H. 
Published: November 2010

SUMMARYThe trend in high‐speed digital circuits is to increase speed and density and to operate at lower voltage. This fast increase in the switching speed combined with the decrease of the operating voltage causes the allowable absolute voltage variations to decrease, which makes the PDS design a more challenging task than ever.Moreover, the complex 3D nature of the modern PDS causes it to be more sensitive to capacitors' placement as well as capacitance value.In this paper, we introduce an efficient complete solution for the design of high‐speed digital PDS. This solution (a) takes the effects of the decoupling capacitor placement into consideration through a 3D electromagnetic simulation of the PDS, (b) defines a more‐realistic PDS design target, and (c) presents a clear capacitor value selection methodology. Finally, we applied our methodology to an industrial test case, compared its results with that of industrial design, and showed its advantages. Copyright © 2010 John Wiley & Sons, Ltd.
Metformin and atorvastatin combination further protect the liver in type 2 diabetes with hyperlipidaemia
Authors: Matafome P. , Louro T. , Rodrigues L. , Crisóstomo J. , Nunes E. , Amaral C. , Monteiro P. , Cipriano A. , Seiça R. 
Published: November 2010

AbstractBackgroundNon‐alcoholic fatty liver disease (NAFLD) and type 2 diabetes are associated with dyslipidaemia, inflammation and oxidative stress. However, the pathophysiology of NAFLD in type 2 diabetes with hyperlipidaemia is not fully known, as well as the utility of the commonly prescribed anti‐diabetic and lipid‐lowering drugs in ameliorating liver injury markers.MethodsHepatic complications of type 2 diabetes with hyperlipidaemia and the effects of atorvastatin and metformin, isolated and in association, in systemic and hepatic inflammatory and oxidative stress markers were tested using genetic type 2 diabetic Goto–Kakizaki rats fed with a high‐fat diet.ResultsThe high‐fat diet aggravated the overall metabolic state and the hepatic markers of injury. All treatments decreased fasting glycaemia, insulin resistance and free fatty acid levels. Combined treatment further decreased C‐reactive protein (CRP), adiponectin, liver tumour necrosis factor‐α (TNF‐α) and interleukin‐6 (IL‐6), systemic and hepatic oxidative stress and portal inflammation.ConclusionsOur data provides evidence of a greater benefit with a combination of atorvastatin and metformin in improving liver injury in type 2 diabetes with hyperlipidaemia. Copyright © 2010 John Wiley & Sons, Ltd.
Advanced motion as a hybrid system
Authors: Suzuki Tatsuya 
Published: November 2010

AbstractThis paper presents a modeling and analysis strategy for advanced complex human motion based on a hybrid system framework. The motion modeling problem is addressed as a parameter estimation problem under the piecewise ARX model, which is a class of hybrid dynamical system. The advantages of motion modeling based on hybrid dynamics are: (1) complex dynamical behavior can be represented in terms of dynamical primitives together with the mechanism of switching between them; (2) the resulting model may be useful for various applications, such as the design of assist controllers, recognition of human behavior, and so on. Finally, the newly developed strategy is applied to a driver's vehicle following task and a peg‐in‐hole task, which represent two typical classes of complex human motion. The results obtained show the usefulness of hybrid dynamics for representing complex human motion. © 2010 Wiley Periodicals, Inc. Electron Comm Jpn, 93(12): 35–43, 2010; Published online in Wiley Online Library (wileyonlinelibrary.com). DOI 10.1002/ecj.10236
A study of spectral correction for self‐absorption of radiation unit in integrating sphere spectral photometer
Authors: Mishima Syunsuke , Oshima Kosei 
Published: November 2010

AbstractIntegrating sphere spectral photometers are used to measure the spectral distribution, to calculate the total luminous flux, and to calculate the chromaticity coordinates of LEDs. When measuring the light source emission in an integrating sphere it is necessary to take account of self‐absorption. LEDs with colored parts, such as printed circuit boards, heat sinks, etc., require special attention. In case of a large enough sphere, the self‐absorption spectrum of an LED has a nearly flat spectral distribution and a low absorption level. Hence, the calculated total luminous flux and chromaticity coordinates of the LED are almost the same regardless of whether the self‐absorption correction is applied or not. In the case of a small integrating sphere, the spectral distribution of LED self‐absorption is slightly affected by spectrum correction samples. The correction spectrum can be measured individually for each color piece with an auxiliary lamp set up in the integrating sphere. After spectral correction, the values of the total luminous flux and chromaticity coordinates measured in a small integrating sphere closely match the results obtained in the large sphere. © 2010 Wiley Periodicals, Inc. Electron Comm Jpn, 93(12): 10–16, 2010; Published online in Wiley Online Library (wileyonlinelibrary.com). DOI 10.1002/ecj.10293
Regulatory T cells exhibit enhanced migratory characteristics, a feature impaired in patients with multiple sclerosis
Authors: Schneider‐Hohendorf Tilman , Stenner Max‐Philipp , Weidenfeller Christian , Zozulya Alla L. , Simon Ole J. , Schwab Nicholas , Wiendl Heinz 
Published: November 2010

AbstractMigration of immune cells characterizes inflammation and plays a key role in autoimmune diseases such as MS. CD4+Foxp3+ regulatory T cells (Treg) have the potential to dampen immune responses but show functional impairment in patients with MS. We here show that murine Treg exhibit higher constitutive cell motility in horizontal migration on laminin, surpass non‐Treg in transwell assays through microporous membranes as well as across primary brain endothelium and are present in the naïve CNS to a significantly higher extent compared to spleen, lymph nodes and blood. Likewise, human Treg from healthy donors significantly exceed non‐Treg in migratory rates across primary human brain endothelium. Finally, we investigated whether the propensity to migrate is impaired as a feature of autoimmunity and therefore tested patients with MS. Treg from patients with stable relapsing‐remitting MS show significantly impaired migratory capacity under non‐inflammatory conditions compared to healthy donors. We hypothesize that the enhanced propensity to migrate is a feature of Treg that allows for an equilibrium in parenchymal immune surveillance, e.g. of the CNS. Impaired Treg migration across the intact blood–brain barrier, as observed for Treg from patients with MS, indicates a broader functional deficiency hypothetically contributing to early CNS lesion development or phases of MS remissions.
Chemical synthesis of phytosterol esters of polyunsaturated fatty acids with ideal oxidative stability
Authors: Qianchun Deng , Pin Zhang , Qingde Huang , Fenghong Huang , Fang Wei , Mingming Zheng , Xiao Yu , Qi Zhou , Chang Zheng 
Published: November 2010

AbstractIn this study, direct esterification of phytosterols with polyunsaturated fatty acid (PUFA) catalyzed by sodium bisulfate to produce sterol esters of PUFA was performed without organic solvent. Considering on both degree of esterification (DE) and oxidative stability, response surface methodology (RSM) was employed for modeling the phytosterol esters of PUFA production to obtain a food grade process. The optimal and mild reaction conditions were obtained as follows: mass ratio of PUFA:phytosterols = 4:1; amount of catalyst: 3% of the raw materials weight; reaction temperature 130°C; reaction time 8 h. Under these conditions, the degree of esterification was up to 96%, GC, TLC, NMR and GC‐MS results showed that purity of purified sterol ester was above 99%, and β‐sitosterol linolenate account for about 88%. Sterol ester of PUFA possessed low peroxide value (PV) (0.96 meq/kg) and conjugated diene (CD) value (2.15 mmol/kg), and high oxidative induction period (OIP) (10.4 h). Addition amount of sterol ester of PUFA into soybean oil, rapeseed oil, and flaxseed oil below 1, 1, and 3%, respectively, could increase OIP of the vegetable oil. The primrose phytosterol esters of PUFA possessed very low melting point, crystallization temperature, and greater solubility in oils. All the characteristics favored the wide application of sterol ester of PUFA produced by the food grade process in different formulations of functional foods.
A Simple and Effective Method for α‐Hydroxylation of β‐Dicarbonyl Compounds Using Oxone as an Oxidant without a Catalyst
Authors: Yu Jun , Cui Jian , Zhang Chi 
Published: November 2010

AbstractOxone has been found to be a highly efficient reagent for the introduction of a hydroxy group at the α position of a variety of β‐dicarbonyl compounds in the homogeneous solvent mixture of water and 1,4‐dioxane at 60 °C.
Nanoporous Gold Leaf for Amperometric Determination of Nitrite
Authors: Ge Xingbo , Wang Liqin , Liu Zhaona , Ding Yi 
Published: November 2010

AbstractUltra‐thin free‐standing nanoporous gold leaf made by dealloying exhibits excellent electrocatalytic activities toward nitrite oxidation. The electrochemical responses of nitrite ions on this novel nano‐electrode is found not dependent on pH over a wide range from 4.5 to 8.0, which is markedly different from that of gold oxidation, a process known to be highly pH‐sensitive. Amperometric study shows a linear relationship for nitrite determination in a concentration range from 1 µM to 1 mM. This nanostructured gold electrode displays good stability, repeatability and selectivity which suggests its potential for the development of new electrochemical sensors.
Electrochemical Study of Gliclazide and Its Complexation with β‐Cyclodextrin
Authors: Radi Abd‐Elgawad , Eissa Shimaa 
Published: November 2010

AbstractThe electrochemical oxidation of gliclazide has been investigated at glassy carbon electrode in phosphate buffer solutions over the pH range 2.7–11.8 using cyclic and differential pulse voltammetry (DPV). Gliclazide exhibited one anodic peak in the pH range of 2.7–6.3 and a second peak was produced above pH 6.3. The oxidation processes have been shown to be irreversible and diffusion controlled. The formation of an inclusion complex of gliclazide with β‐cyclodextrin (β‐CD) has been investigated by cyclic and differential pulse voltammetry. A phase solubility study with spectrophotometric detection has been also applied. The stability constant of the complex was determined to be 839 and 360 M−1 using the differential pulse voltammetric method and the phase solubility method, respectively.
Responses of Metalloporphyrin‐Based Ion‐Selective Electrodes to pH
Authors: Inoue Takuya , Baba Toshiyuki , Yuchi Akio 
Published: November 2010

AbstractThe ISEs based on [M(tpp)Cl] (M: Al, Ga, In, Mn, Fe; H2tpp: tetraphenylporphin) had pH responses across their respective pH ranges, which had some correlation with the pH ranges of the two‐phase hydrolysis. Such pH responses are ascribed to the phase boundary potentials relating to the acid‐base pairs of [M(tpp)(H2O)]+ and [M(tpp)(OH)] and/or [M2(tpp)2O]. The potential responses of the In and Fe complexes had the upper limitation to pH of 90 % hydrolysis, whereas those of the Al and Ga complexes had the extension to at least pH 12, indicating stable existence of [M(tpp)(H2O)]+ even in contact with strongly alkaline solutions.
The Electrochemical Behavior of Gold Nanoparticle‐Tantalum(V) Phthalocyanine Composites: Applications Towards the Electroanalysis of Bisphenol A
Authors: Chauke Vongani P. , Chidawanyika Wadzanai , Nyokong Tebello 
Published: November 2010

AbstractThe formation of gold nanoparticle (AuNP) composites with tantalum phthalocyanines (TaPc) complexes {1a and 1b (Figure 1)} is reported. The TaPc‐AuNPs conjugates were characterised by atomic force microscopy (AFM) and transmission electron microscopy. The AFM analyses show that conjugates of TaPc with AuNPs are more aggregated when compared to AuNPs alone. The conjugates and TaPc complexes were immobilized on a gold electrode by drop and dry method and these were characterized by electrochemical impedance spectroscopy. The charge transfer behaviour of AuNPs was enhanced in the presence of TaPc complexes. All the modified electrodes showed electrocatalytic oxidation of bisphenol A. The limits of detection for complexes 1a and 1b were 4.78×10−10 and 2.76×10−10 mol L−1, respectively.
Numerical pricing of American options under infinite activity Lévy processes
Authors: Rambeerich Nisha , Tangman Desire Yannick , Bhuruth Muddun 
Published: November 2010

AbstractUnder infinite activity Lévy models, American option prices can be obtained by solving a partial integro‐differential equation (PIDE), which has a singular kernel. With increasing degree of singularity, standard time‐stepping techniques may encounter difficulties. This study examines exponential time integration (ETI) for solving this problem and the performance of this scheme is compared with the Crank–Nicolson (CN) method and an implicit–explicit method in conjunction with an extrapolation (IMEX‐Extrap), in terms of computational speed and convergence orders. These findings indicate that ETI is faster and more accurate among PIDE‐based methods for solving the system of ordinary differential equations resulting from spatial discretization of the PIDE. For very singular problems, it is shown that the IMEX‐Extrap scheme becomes unfavorable compared with the other schemes as it is relatively more time consuming and the global convergence deteriorates from quadratic to linear, whereas the ETI scheme yields both point‐wise and global quadratic convergence. For illustration, under the infinite variation process, the IMEX‐Extrap achieves a precision of the order of 10−4 in 663.016 s, whereas for the same set of parameters, the CN method and the ETI scheme reach an accuracy of the order of 10−5 in 237.891 s and 22.772 s, respectively. © 2010 Wiley Periodicals, Inc. Jrl Fut Mark 31:809–829, 2011
Distributed modelling of future changes in hydrological processes of Spencer Creek watershed
Authors: Sultana Zakia , Coulibaly Paulin 
Published: November 2010

AbstractThe hydrologic impact of climate change has been largely assessed using mostly conceptual hydrologic models. This study investigates the use of distributed hydrologic model for the assessment of the climate change impact for the Spencer Creek watershed in Southern Ontario (Canada). A coupled MIKE SHE/MIKE 11 hydrologic model is developed to represent the complex hydrologic conditions in the Spencer Creek watershed, and later to simulate climate change impact using Canadian global climate model (CGCM 3·1) simulations. Owing to the coarse resolution of GCM data (daily GCM outputs), statistical downscaling techniques are used to generate higher resolution data (daily precipitation and temperature series). The modelling results show that the coupled model captured the snow storage well and also provided good simulation of evapotranspiration (ET) and groundwater recharge. The simulated streamflows are consistent with the observed flows at different sites within the catchment. Using a conservative climate change scenario, the downscaled GCM scenarios predicted an approximately 14–17% increase in the annual mean precipitation and 2–3 °C increase in annual mean maximum and minimum temperatures for the 2050s (i.e., 2046–2065). When the downscaled GCM scenarios were used in the coupled model, the model predicted a 1–5% annual decrease in snow storage for 2050s, approximately 1–10% increase in annual ET, and a 0·5–6% decrease in the annual groundwater recharge. These results are consistent with the downscaled temperature results. For future streamflows, the coupled model indicated an approximately 10–25% increase in annual streamflows for all sites, which is consistent with the predicted changes in precipitation. Overall, it is shown that distributed hydrologic modelling can provide useful information not only about future changes in streamflow but also changes in other key hydrologic processes such as snow storage, ET, and groundwater recharge, which can be particularly important depending on the climatic region of concern. The study results indicate that the coupled MIKE SHE/MIKE 11 hydrologic model could be a particularly useful tool for understanding the integrated effect of climate change in complex catchment scale hydrology. Copyright © 2010 John Wiley & Sons, Ltd.
Biophysical characterization of ovine forestomach extracellular matrix biomaterials
Authors: Floden Evan W. , Malak Sharif F. F. , Basil‐Jones Melissa M. , Negron Leonardo , Fisher James N. , Lun Stan , Dempsey Sandi G. , Haverkamp Richard G. , Ward Brian R. , May Barnaby C. H. 
Published: November 2010

AbstractOvine forestomach matrix (OFM) is a native and functional decellularized extracellular matrix biomaterial that supports cell adhesion and proliferation and is remodeled during the course of tissue regeneration. Small angle X‐ray scattering demonstrated that OFM retains a native collagen architecture (d spacing = 63.5 ± 0.2 nm, orientation index = 20°). The biophysical properties of OFM were further defined using ball‐burst, uniaxial and suture retention testing, as well as a quantification of aqueous permeability. OFM biomaterial was relatively strong (yield stress = 10.15 ± 1.81 MPa) and elastic (modulus = 0.044 ± 0.009 GPa). Lamination was used to generate new OFM‐based biomaterials with a range of biophysical properties. The resultant multi‐ply OFM biomaterials had suitable biophysical characteristics for clinical applications where the grafted biomaterial is under load. © 2010 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2011.