bluuebunny/crossref_metadata_2025_split huggingface dataset:
Increased soluble interleukin 2 receptor levels in autoimmune thyroid disease
Authors: Nakanishi Kimio , Taniguchi Yoshiyasu , Ohta Yasuyuki 
Published: June 2009

Abstract.
We measured soluble interleukin 2 receptor, a part of the Tac protein (p55), in peripheral blood to study the immunological condition of the T cell in autoimmune thyroid disease. In 26 patients with untreated Graves' disease and 7 hyperthyroid patients with Hashimoto's thyroiditis, the mean levels of soluble IL-2 receptor were both significantly higher than in normal controls (1497±649 (mean ± sd), 641±137 vs 221±63 103 U/l, p<0.001). There was good correlation between soluble IL-2 receptor levels and blood thyroxine levels (r=0.684, p<0.001) in patients with untreated Graves' disease, but no correlation of soluble IL-2 receptor with TSH-inhibitory immunoglobulins, TS-ab, thyroidal autoantibodies to thyroglobulin and thyroidal microsomal antigen was found. We thought that the level of soluble IL-2 receptor is not dependent only on immunological conditions, but also on thyroid hormone status. When T3 was administered to subjects in remission from Graves' disease and in normal controls, the soluble IL-2 receptor levels significantly increased. Moreover, the mean level of soluble IL-2 receptor in patients with toxic multinodular goitre was also significantly higher than in normal controls (411±148 vs 221±63 103U/l, p<0.05). We conclude that the soluble IL-2 receptor levels are higher in sera of subjects with elevated levels of thyroid hormone.
Influence of pregnancy on the serum prolactin level following prolactinoma surgery
Authors: Hirohata Taizo , Uozumi Tohru , Mukada Kazutoshi , Arita Kazunori , Kurisu Kaoru , Yano Takashi , Takechi Akihiko , Onda Jun 
Published: June 2009

Abstract.
We studied the influence of pregnancy on the serum prolactin levels after surgery in 35 patients with prolactinomas. Eighteen out of 22 patients with postoperative normalization of the prolactin level were able to achieve repeated spontaneous pregnancies and endocrine cure by surgery alone, but the other 4 had recurrent hyperprolactinemia. Thirteen patients with persistent hyperprolactinemia after surgery achieved one pregnancy with or without bromocriptine treatment, but did not achieve a second one owing to an increase in the prolactin level after delivery. None of the patients with postoperative hyperprolactinemia showed spontaneous normalization of the prolactin level or restoration of menstruation after delivery. In these 13 patients, the mean increase from the postoperative to the post-delivery prolactin level was less for the patients with bromocriptine-induced pregnancy than for those with spontaneous pregnancy. It is concluded that pregnancy did not adversely affect the serum prolactin level in the patients with a normal post-operative level.
Inhibition of protein kinase C by staurosporine increases estrogen secretion by rat Sertoli cells
Authors: Lambert Ann , Talbot J. Alan , Mitchell Robert , Robertson William R. 
Published: June 2009

Abstract
We have examined the effect of inhibition of protein kinase C activity by staurosporine on estradiol secretion by Sertoli cells isolated from 8–10 days old rats. Staurosporine lead to a dose-related increase in estradiol secretion independent of FSH, such that with 100 nmol/l staurosporine basal estradiol levels increased 10-fold. The maximal response seen with staurosporine alone (100 nmol/l) or in combination with FSH (0.4–8 IU/l) was similar to that seen with a saturating dose of FSH (8 IU/l). There was no evidence of synergy between FSH and staurosporine. Activation of protein kinase C by phorbol 12,13 dibutyrate (10−7 mol/l) resulted in a 53–74% inhibition of estradiol production provoked by FSH (8 IU/l), staurosporine (5–100 nmol/l) or staurosporine in combination with FSH. Staurosporine (5–100 nmol/l), in the absence or presence of FSH, was unable to overcome inhibition of estradiol secretion by phorbol ester, indicating the presence of at least two independent binding sites on protein kinase C for these molecules. Forskolin (1 μmol/l)- and dibutyryl cAMP (1 mmol/l)-stimulated estradiol secretion was inhibited by 31±5% and 64±5% respectively, by phorbol 12,13 dibutyrate (10−7 mol/l). We conclude that FSH-induced estradiol secretion in immature rat Sertoli cells is affected by protein kinase C activity.
Circulating thyroglobulin measurements by homologous radioimmunoassay in dogs with thyroid carcinoma
Authors: Verschueren C. P. , Selman P. J. , Mol J. A. , Vos J. H. , van Dijk J. E. , Sjollema B. E. , de Vijlder J. J. M. 
Published: June 2009

Abstract.
Circulating thyroglobulin was measured in 20 dogs with thyroid cancer, using a homologous polyclonal radioimmunoassay. Plasma Tg levels exceeded the normal range in 14 (70%) dogs, and ranged from 6 to 2902 μg/l (median 608). Plasma Tg levels tended to decrease from follicular carcinomas to solid-follicular carcinomas, to solid carcinomas (p<0.05). Plasma Tg levels were also higher in scintigraphically hot tumours than in cold ones. Other relationships between circulating Tg and clinical, pathological, and functional parameters were not found, except a poor (R=0.49) but significant (p=0.04) correlation between Tg and T4 levels. Plasma Tg was measured before surgery and at least once during followup, in 9 dogs. After hemithyroidectomy, a decrease was observed in 8 dogs. In 7 of these 8 dogs, plasma Tg levels declined within the reference range at the first postoperative sample. In the ninth dog, where metastases were detected 14 months after surgical treatment, plasma Tg slightly increased, yet within normal range. It is concluded that measurement of plasma Tg levels might be useful for monitoring the postoperative course of the disease in individual dogs with thyroid cancer.
Two polyclonal antisera to rat luteal LH/CG receptor with different ligand binding inhibition and immunohistochemical receptor detection capabilities
Authors: Lakkakorpi Jouni T. , Keinänen Kari P. , Rajaniemi Hannu J. 
Published: June 2009

Abstract.
Polyclonal antisera to a SDS-denatured and partially renatured rat luteal 90 K LH/CG receptor were raised in rabbits, characterized, and their applicability for immunohistochemical location of the receptor examined. The LH/CG receptor was purified by hCG-affinity chromatography and subjected either to a preparative SDS-PAGE or Western blotting. Gel slices containing the SDS-denatured or nitrocellulose strips containing the renatured 90 K LH/CG receptor were used for immunization. The antisera, termed ARS-2 and ARS-3, respectively, possessed similar antibody titres. Both antisera were able to recognize the native, SDS-denatured, and SDS-denatured and reduced forms of the LH/CG receptor on dot blots, but only ARS-3 contained antibodies to the hormone binding site or a region near to it, as it was able to inhibit the hCG binding to the membrane-bound LH/CG receptor in a dilution-dependent manner. Both antisera recognized the receptor-hCG complex, but ARS-2 stained the complex with about 50% less intensity than the free receptor. ARS-3 located the LH/CG receptor distinctly on the luteal cell surfaces in immunohistochemical staining with peroxidase antiperoxidase complex method, but ARS-2, although it possessed similar antibody titre, revealed negligible staining. Thus, the antisera readily recognize the native receptor, but differ in their capability for inhibiting hormone binding. Only ARS-3, produced against the renatured receptor, contains sufficient amounts of antibodies capable of recognizing free and occupied receptors in immunohistochemistry.
In vivo and in vitro inhibition by ketoconazole of ACTH secretion from a human thymic carcinoid tumour
Authors: Steen Reidar Eilif , Kapelrud Helge , Haug Egil , Frey Harald 
Published: June 2009

Abstract.
We treated a patient with an ectopic ACTH-producing thymic carcinoid tumour with ketoconazole. The treatment decreased blood levels of ACTH and cortisol and relieved the patient's symptoms. Tumour explants secreted ACTH to the culture medium for at least 11 days. The tumour cells responded to high extracellular K+ concentration with increased ACTH secretion, whereas the hypothalamic ACTH-releasing hormone (CRH) and cortisol had no effect on ACTH secretion. Addition of ketoconazole to the culture medium decreased ACTH secretion showing that ketoconazole had a direct effect on the tumour cells.
Erythrocytes from patients with low serum concentrations of IGF-I have an increase in receptor sites for IGF-I
Authors: Eshet R. , Dux Z. , Silbergeld A. , Koren R. , Klinger B. , Laron Z. 
Published: June 2009

Abstract.
The binding characteristics of insulin-like growth factor I on erythrocytes were studied in 11 patients with long-term IGF-I deprivation and low serum IGF-I levels. Six patients had Laron type dwarfism and 5 idiopathic isolated growth hormone deficiency, with a mean (± sem) serum IGF-I level of 6.01±1.01 nmol/l as compared with that in 25 normal controls of 26.35±2.73 nmol/l (p=0.00001). The mean (± sem) [125I]IGF-I specific binding at a concentration of 4×1012 cell/l was 12.11±1.29% for the patient group compared with 8.75±0.62% for the controls (p=0.005). Scatchard analysis showed a curvilinear plot. Using a non-linear curve fit, the mean (± sem) number of high-affinity receptor sites per cell was found to be 7.34±1.80 in the IGF-I-deprived patients and 2.84±0.29 in the controls (p=0.0005). The mean ± sem dissociation constant was found to be 0.33±0.10 nmol/l for the patients and 0.26±0.08 nmol/l for the controls (NS). This study has demonstrated that the low serum concentration of IGF-I in Laron type dwarfism and isolated growth hormone deficiency is associated with an increase in receptor sites for IGF-I on the erythrocytes. The application of this property as a diagnostic aid remains to be established.
Human anterior pituitary response to exogenous arginine vasopressin
Authors: Meller William H. , Lewis David A. , Gehris Timothy L. , Kathol Roger G. 
Published: June 2009

Abstract.
The adrenocorticotropin-releasing effect of arginine vasopressin is well known. The effects of AVP on other anterior pituitary hormones remain confusing, with few in vivo human data available. Two human studies of exogenous AVP effects on ACTH, GH, TSH and prolactin are described. In the dosage and route of administration used, AVP was found to be a specific ACTH secretagogue.
Effects of triiodothyronine, triiodothyroacetic acid, iopanoic acid and iodide on the thyrotropin-releasing hormone-induced thyrotropin release from superfused rat pituitary fragments
Authors: Szaboles I. , Schultheiss H. , Astier H. , Horster F. A. 
Published: June 2009

Abstract.
The effects of triiodothyronine, triiodothyroacetic acid, iopanoic acid and potassium iodide were investigated on basal and stimulated thyrotropin release in an in vitro experimental model. Rat pituitary fragments were superfused by Medium-199 with or without T3 (10−7 mol/l), triiodothyroacetic acid (10−8-10−6 mol/l), iopanoic acid (10−7-10−5 mol/l) or potassium iodide (10−7-10−4 mol/l). This was followed by a 6-min pulse of thyrotropin-releasing hormone (10−8 mol/l). TSH was measured in 3-min fractions. The TRH-induced TSH release from the pituitary fragments was inhibited by T3 (10−7 mol/l), by triiodothyroacetic acid (10−7-10−6 mol/l), and by high concentrations of iodide (10−4 or 10−5 mol/l). Iopanoic acid had no significant effect at the concentrations tested. It is assumed that in vitro, and at similar concentrations, the inhibitory effect of triiodothyroacetic acid on the TRH-induced TSH secretion is comparable to that of T3, whereas iopanoic acid may have no direct detectable effect. In contrast, a direct inhibitory effect of inorganic iodide, at least in pharmacological concentrations in vivo, cannot be excluded.
The neuropeptide, head activator, in human placenta and serum from pregnant women
Authors: Sakura Harutake , Aoki Shigeru , Ozawa Takachika , Hashimoto Tadashi , Sakura Naoki 
Published: June 2009

Abstract.
The hydra neuropeptide, head activator, was detected in human placenta using radioimmunoassay. The placenta contained 11-68 fmol/g wet weight of head activator. The slope of the inhibition curve by placental extract in radioimmunoassay was identical to that of synthetic head activator. The molecular weight of the major immunoreactive head activator in placental extract corresponded to the synthetic head activator after Bio-Gel P-2 column chromatography. The peak of immunoreactive head activator in the extract emerged at the same retention time as that of the synthetic head activator on reversed-phase high-performance liquid chromatography. Head activator was localized histologically in trophoblasts of placenta by peroxidase-antiperoxidase staining techniques. The head activator staining was inhibited by the excessive synthetic head activator. The serum head activator level during pregnancy ranged from 9 to 31 pmol/l. A positive linear correlation was found between serum head activator content and gestational weeks.
Plasma glucagon and glucose recovery after hypoglycemia: The effect of total autonomic blockade
Authors: Hilsted J. , Frandsen H. , Holst J. J. , Christensen N. J. , Nielsen S. L. 
Published: June 2009

Abstract.
The role of the autonomic nervous system in the glucagon response to hypoglycemia has not been fully clarified. We have studied the effect of total pharmacological blockade of the autonomic nervous system (concomitant α- and β- adrenergic blockade with simultaneous atropine injection) and of isolated α-adrenergic blockade on hormonal responses to hypoglycemia and on blood glucose recovery after hypoglycemia in healthy subjetcs. Neither of the pharmacological blockades had any significant effects on plasma glucagon responses to hypoglycemia nor had they any effect on the rate of blood glucose recovery after hypoglycemia. We conclude that the autonomic nervous system has no major influence on the glucagon response to hypoglycemia in healthy man. Changes in autonomic nervous activity are not essential for blood glucose recovery after hypoglycemia in healthy man.
Diurnal variation and left-right distribution of pyroglutamyl peptidase I activity in the rat brain and retina
Authors: Ramirez M. , Sanchez B. , Arechaga G. , Garcia S. , Lardelli P. , Venzon D. , de Gandarias J. M. 
Published: June 2009

Abstract.
The thyroliberin and luliberin contents exhibit a diurnal rhythm within the brain and an asymmetrical distribution of both neuropeptides has been demonstrated in the hypothalamus. Since they have been described as substrates of pyroglutamyl peptidase I, this activity was analysed in several rat brain regions and other structures, in order to investigate its putative diurnal variations and changes in relation to the distribution of these neuropeptides and/or other susceptible substrates. Fluorometric activity was assayed in the retina, pituitary gland, superior cervical ganglia, pineal gland, some selected brain regions, and serum of adult male rats at six different time points of a 12:12 h light:dark cycle, using pyroglutamyl-β-naphthylamide as substrate. A significant circadian rhythm was demonstrated in the retina, the hypothalamus, and the intermediate-posterior pituitary lobe. In addition, a small but significant asymmetrical distribution of this activity, at certain time points, was disclosed: The activity was higher in the left than in the right retina at 10 h of the light period, whereas it was predominant in the right side at 01 h of the dark period. Furthermore, the activity was higher in the left anterior than in the right hypothalamic area at 13 and 01 h. These results could be indicative of a role of this enzymatic activity in the control of the functional status of its endogenous substrates.
Oral estradiol-17β raises the level of plasma high-density lipoprotein in menopausal women by slowing down its clearance rate
Authors: Quintão Eder C. R. , Nakandakare Edna , Oliveira Helena C. F. , Rocha Jussara C. , Garcia Roberto C. , de Melo Nilson R. 
Published: June 2009

Abstract.
Plasma lipoprotein composition, plasma kinetics of autologous [125I]HDL and the metabolism of iv administered radioactively labelled artificial chylomicrons were studied in postmenopausal women during a control period and after 4 months of oral estradiol-17β treatment (1 mg/m2 body surface per day). Drug treatment significantly raised plasma HDL-cholesterol levels (19%) in the fasting state and total apolipoprotein A-I (16%), but did not interfere with triglyceride, VLDL, LDL or apolipoprotein-B values. As compared with the control period, estradiol-17β administration significantly slowed down plasma [125I]HDL clearance by about 82% and reduced the delipidation index of the injected artificial chylomicrons by 47% as a consequence of impaired plasma lipolytic activity.
Measurement of intact parathyroid hormone in the diagnosis of hyperparathyroidism
Authors: Bergenfelz Anders , Valdermarsson Stig , Ahrén Bo 
Published: June 2009

Abstract.
Plasma levels of parathyroid hormone were determined pre-operatively in 27 consecutive patients with clinical and biochemical signs of primary hyperparathyroidism, by the use of one assay recognizing the intact PTH molecule and one assay recognizing the mid-portion of PTH. Plasma levels of mid-molecule PTH were normal in 5 of the patients with primary hyperparathyroidism. In 4 of these patients, plasma levels of intact PTH were raised. Conversely, in 6 patients with primary hyperparathyroidism, intact PTH were normal pre-operatively. In 5 of these cases, plasma levels of mid-molecule PTH were raised. The EDTA infusion test was performed in 6 patients with normal baseline plasma level of intact PTH pre-operatively. The test correctly predicted all the patients in this group who were found to have primary hyperparathyroidism, as well as a patient with normal parathyroid glands found at operation. We conclude that some patients with primary hyperparathyroidism have normal baseline plasma levels of intact PTH. In these patients, plasma levels of mid-molecule PTH and an EDTA infusion test provide further diagnostic information.
Foreign Oil
Authors: Duce James Terry 
Published: June 2009

Introduction
When I came to Texas it is always an open question in my mind as to whether I should ask for protection from the Texas Rangers. Indeed, I am never quite certain whether I will leave your beautiful city on a train, airplane or riding on a rail, and when some Texan calls me "my fine feathered friend", I have a kind of suspicion that he is looking in the direction of a tar barrel. That is, of course, the penalty of success anywhere but Texas!
But, all joking aside, I am now confronted with the problem of talking to you about a basis for the valuation of oil properties abroad. I shall assume that my assignment covers properties other than those in the United States and Canada. I might begin by saying the science of valuation of foreign oil properties is in its infancy, if it is a science at all, for not many foreign properties are transferred and those that are transferred are usually transferred on the basis of considerations other than their money value. When I go over the number of foreign properties that I know to have been sold, I come up with a very small number -the Barco concession, the various interests of the Arabian American Oil Co., the Venezuelan royalties of Barber Asphalt Co., and such trades as were made by the Texas Company for its interest in the properties of the Caracas Petroleum, the Lago Purchase by Esso from Standard of Indiana, the Creole trade, the purchase of London-Pacific Petroleum's Parinas Estate at Negritos and Talara, Peru by International Petroleum in (or about)1916, and the deal made by Shell and Jersey for interest in Mene Grande(Gulf) production. The trouble with any discussion of such trades is that beside the value of the actual oil content of the property, the really important considerations lie within the time-honored expression "discount for risk and hazard" and in many of the major properties the recovery of the oil in the fields is so much deferred that the valuation tables will give you the astonishing information that much of the oil is of practically no value at all.
Effect of cobalt on the electrical conductive property of epoxy resins
Authors: Mohan Pragyan 
Published: June 2009

AbstractCobalt acrylate (CoA2) has been treated with bisphenol‐A and epichlorohydrin to modify epoxy resins. It was cured with p‐acetylbenzilidene triphenyl arsonium ylide. The properties such as epoxide equivalent weight (equiv/100 g), molecular weight, hydrolyzable chlorine content increases whereas hydroxyl content, refractive index decreases in the presence of CoA2. The cured epoxy resins shows improve electrical conductivity due to the incorporation of CoA2 with epoxy resins. The influence of complex formation of CoA2 with either linkage of epoxy resins were investigated by spectroscopy. The decrease in Tg from differential scanning calorimetry support the improve in flexibility. The dispersion of cobalt in epoxy resins matrix was confirmed by scanning electron microscope. © 2009 Wiley Periodicals, Inc. J Appl Polym Sci, 2009
Rupture of a peripheral popliteal artery plaque documented by intravascular ultrasound: A case report
Authors: Kohno Hiroaki , Sueda Shozo 
Published: June 2009

AbstractA 58‐year‐old male with dyslipidemia and coronary spastic angina suddenly experienced pain in the right limb while walking on November 1, 2008. Right‐ankle brachial pressure index (ABI) was decreased (0.80) and left‐ABI was normal (1.24). Bilateral ABI was normal during January 2008. Ultrasonography in the right‐lower limb artery revealed severe stenosis in the right‐popliteal artery with extended and large echolucent plaques containing an isoechoic area. We carried out lower limb angiography: subtotal occlusion of the popliteal artery was found. By intravascular ultrasound (IVUS), right‐popliteal artery plaques were echolucent and eccentric; ulceration with a thin fibrous cap was noted. Percutaneous transluminal angioplasty was done and popliteal artery blood flow was improved. Right‐ABI improved to 1.13 after 4 days. To prevent the progression and rupture of the plaques, lipid‐lowering therapy and antiplatelet therapy were started. Plaque rupture of the popliteal artery was diagnosed by these characteristics on IVUS. Patients with peripheral artery disease may have plaque rupture similar to those with acute coronary syndromes who have identical unstable plaques and unstable atheromas. In addition to appropriate local revascularization, systemic therapy to stabilize the unstable plaque is indicated because failure to do so may cause recurrent events. © 2009 Wiley‐Liss, Inc.
Electrochemical Quartz Crystal Microbalance Study of FeS Particles Attached to Au Surface
Authors: Bura‐Nakic Elvira , Róka András , Ciglenecki Irena , Inzelt György 
Published: June 2009

AbstractElectrochemical quartz crystal microbalance (EQCM) measurements were employed for studying of the redox processes of FeS microparticles immobilized on Au electrode surface in contact with aqueous solutions of NaCl, NaCl‐NaHCO3, and NaCl‐Na2S. The objective was to shed light on the complexity of the iron sulfide electrochemistry. For the sake of comparison electrochemical behavior of FeS suspension was also investigated on the paraffin‐impregnated graphite (PIGE) and hanging mercury drop (HMDE) electrodes. In order to understand the complex nature of the redox transformations of FeS, Mohr‐salt was dissolved in NaCl and NaCl‐NaHCO3 solutions, respectively, and the deposition‐dissolution processes occurring in the course of the reduction of Fe(II) and reoxidation of Fe(0) were also monitored.
Lacosamide: new adjunctive treatment for partial seizures
Authors: Chaplin Steve , Hart Yvonne 
Published: June 2009

AbstractLacosamide (Vimpat), which is hypothesised to have a novel dual mode of action, is a new antiepileptic drug licensed as adjunctive therapy for partial seizures. In our New products review Steve Chaplin presents the clinical data relating to its efficacy and adverse effects, and Dr Yvonne Hart comments on its place in treatment. Copyright © 2009 Wiley Interface Ltd