bluuebunny/crossref_metadata_2025_split huggingface dataset:
Vibrational‐Mode‐Selective Modulation of Electronic Excitation
Authors: Guan Jianxin , Li Xinmao , Shen Chengzhen , Zi Zhi , Hou Zhuowei , Hao Chuanqing , Yu Qirui , Jiang Hong , Ma Yuguo , Yu Zhihao , Zheng Junrong 
Published: May 2024

AbstractVibrational‐mode‐selective modulation of electronic excitation is conducted with a synchronized femtosecond (fs) visible (vis) pulse and a picosecond (ps) infrared (IR) pulse. The mechanism of modulation of vibrational and vibronic relaxation behavior of excited state is investigated with ultrafast vis/IR, IR/IR, and vis‐IR/IR transient spectroscopy, optical gating experiments and theoretical calculations. An organic molecule, 4′‐(N,N‐dimethylamino)‐3‐methoxyflavone (DMA3MHF) is chosen as the model system. Upon 1608 cm−1 excitation, the skeleton stretching vibration of DMA3MHF is energized, which can significantly change the shape of the absorption, facilitate the radiative decay and promote emission from vibrational excited states. As results, a remarkable enhancement and a slight blueshift in fluorescence are observed. The mode‐selective modulation of electronic excitation is not limited in luminescence or photophysics. It is expected to be widely applicable in tuning many photochemical processes.
The HABD: Home of All Biological Databases Empowering Biological Research With Cutting‐Edge Database Systems
Authors: Ullah Shahid , Rahman Wajeeha , Ullah Farhan , Ullah Anees , Ahmad Gulzar , Ijaz Muhammad , Ullah Hameed , Sharafmal Din Mohammad 
Published: May 2024

AbstractThe emergence of computer technologies and computing power has led to the development of several database systems that provide standardized access to vast quantities of data, making it possible to collect, search, index, evaluate, and extract useful knowledge across various fields. The Home of All Biological Databases (HABD) has been established as a continually expanding platform that aims to store, organize, and distribute biological data in a searchable manner, removing all dead and non‐accessible data. The platform meticulously categorizes data into various categories, such as COVID‐19 Pandemic Database (CO‐19PDB), Database relevant to Human Research (DBHR), Cancer Research Database (CRDB), Latest Database of Protein Research (LDBPR), Fungi Databases Collection (FDBC), and many other databases that are categorized based on biological phenomena. It currently provides a total of 22 databases, including 6 published, 5 submitted, and the remaining in various stages of development. These databases encompass a range of areas, including phytochemical‐specific and plastic biodegradation databases. HABD is equipped with search engine optimization (SEO) analyzer and Neil Patel tools, which ensure excellent SEO and high‐speed value. With timely updates, HABD aims to facilitate the processing and visualization of data for scientists, providing a one‐stop‐shop for all biological databases. Computer platforms, such as PhP, html, CSS, Java script and Biopython, are used to build all the databases. © 2024 Wiley Periodicals LLC.
Valorization of Lignocellulose with One‐Step Acidified Monophasic Phenoxyethanol Fractionation
Authors: Zhang Yiqi , Wang Yunxuan , Li Wuhuan , Liu Shijun , Tan Xuesong , Zhang Quan , Miao Changlin , Gao Jingjing , Song Xueping , Sun Chihe , Li Kai , Ragauskas Arthur J. , Zhuang Xinshu 
Published: May 2024

AbstractEffective fractionation of lignocelluosic biomass and subsequent valorization of all three major components under mild conditions were achieved. Pretreatment with acidified monophasic phenoxyethanol (EPH) efficiently removed 92.6 % lignin and 80 % xylan from poplar at 110 °C in 60 min, yielding high‐value EPH‐xyloside, EPH‐modified lignin (EPHL), and a solid residue nearly purely composed of carbohydrates. After removing the grafted acetyl groups using 1 % NaOH at 50 °C, the highest enzymatic digestibility reached 92.3 %. EPHL could be recovered in high yield and purity with an uncondensed structure, while xylose was converted to EPH‐xyloside, a potential precursor in biomedical industries. Additionally, the acidified monophasic EPH solvent could effectively fractionate biomass from species other than hardwood, achieving over 70 % delignification from recalcitrant pinewood under the same mild conditions, demonstrating the high potential of monophasic EPH pretreatment.
The impact of chronic fluoxetine treatment in adolescence or adulthood on context fear memory and perineuronal nets
Authors: Chan Diana , Baker Kathryn D. , Richardson Rick 
Published: May 2024

AbstractSelective serotonin reuptake inhibitors, such as fluoxetine (Prozac), are commonly prescribed pharmacotherapies for anxiety. Fluoxetine may be a useful adjunct because it can reduce the expression of learned fear in adult rodents. This effect is associated with altered expression of perineuronal nets (PNNs) in the amygdala and hippocampus, two brain regions that regulate fear. However, it is unknown whether fluoxetine has similar effects in adolescents. Here, we investigated the effect of fluoxetine exposure during adolescence or adulthood on context fear memory and PNNs in the basolateral amygdala (BLA), the CA1 subregion of the hippocampus, and the medial prefrontal cortex in rats. Fluoxetine impaired context fear memory in adults but not in adolescents. Further, fluoxetine increased the number of parvalbumin (PV)‐expressing neurons surrounded by a PNN in the BLA and CA1, but not in the medial prefrontal cortex, at both ages. Contrary to previous reports, fluoxetine did not shift the percentage of PNNs toward non‐PV cells in either the BLA or CA1 in the adults, or adolescents. These findings demonstrate that fluoxetine differentially affects fear memory in adolescent and adult rats but does not appear to have age‐specific effects on PNNs.
Recycled by leaf inhabitants: Terrestrial bacteria drive the mineralization of organic matter in lake water
Authors: Vesamäki Jussi S. , Rigaud Cyril , Litmanen Jaakko J. , Nissinen Riitta , Taube Robert , Taipale Sami J. 
Published: May 2024

AbstractTerrestrial organic matter subsidizes aquatic food webs and plays an important role in carbon cycling in lake ecosystems, where it is decomposed mainly by microbes. However, the contribution of terrestrial and aquatic microbiomes on terrestrial carbon cycling and their effects on the biochemical fate of carbon has remained understudied. Therefore, we explored the microbial carbon utilization of three chemically differing leaf species in lake water in microcosms and quantified the biochemical endpoints of leaf carbon in CO2, CH4, and microbial biomass. Additionally, we identified microbial taxa responsible for leaf carbon recycling and studied the role of epiphytic and endophytic leaf microbiomes in microbial community succession in lake water. Microbially utilized leaf carbon was mainly respired (82.7 ± 1.4%), whereas a small proportion (17.1 ± 1.4%) was assimilated into biomass. Carbon from nitrogen‐rich alder leaves was taken up at the fastest rate, whereas birch leaf addition produced the highest concentrations of CH4, suggesting that leaf chemistry affects the decomposition rate and biochemical fate of carbon. In particular, terrestrial bacteria shaped the succession of aquatic bacterial communities. The addition of leaves resulted in the equal contribution of epiphytic and endophytic bacteria in the lake water, whereas epiphytic fungi dominated the fungal community structure. Our results suggest that terrestrial bacteria originating from terrestrial leaves influence the microbiome succession in lake ecosystems and play a key role in linking terrestrial carbon to an aquatic food web and determining the quality of carbon emissions that are released into the atmosphere.
Synthesis of β‐Trifluoromethylated Ketones by Photocatalyzed Deoxygenative Coupling of Aromatic Acids with α‐CF3‐Substituted Styrenes
Authors: Zhang Lili , Yu Xiaoyu , Ouyang Shenmao , Zhu Chengjian , Li Weipeng , Xie Jin 
Published: May 2024

Abstractα‐Trifluoromethyl alkenes are versatile CF3‐containing feedstocks. They have been widely used to construct gem‐difluoroalkene scaffolds through β−F elimination. The application of α−CF3 alkenes as trifluoromethylating reagents has been less explored. Herein, we report an efficient route for the synthesis of β‐trifluoromethylated ketones from readily accessed α−CF3 styrenes and aromatic carboxylic acids under photoredox catalysis. The reactions proceed by phosphoranyl radical promoted deoxygenation of aromatic acids, generating acyl radicals for subsequent hydroacylation of α−CF3 styrenes. The valuable trifluoromethyl‐containing compounds could be produced in good yields under mild conditions.
A cross‐sectional, multicenter survey of the prevalence and influencing factors for migraine in epilepsy
Authors: Shi Wenyan , Sun Hanlin , Peng Wei , Chen Ziyi , Wang Qun , Lin Weihong , Ding Meiping , Sun Hongbin , Wang Xiangqing , Wang Tiancheng , Wang Xuefeng , Liu Yonghong , Chen Yangmei , Zhu Guoxing , Zhou Dong , Li Jinmei 
Published: May 2024

AbstractObjectivesEpilepsy and migraine are common chronic neurological disease. Epidemiologic studies and shared pathophysiology and treatment suggest that these two diseases overlap. However, migraine is often underestimated among patients with epilepsy. This study aimed to evaluate the prevalence of migraine and identify the related influencing factors among adult patients with epilepsy.MethodsAdult patients with epilepsy were recruited at the outpatient epilepsy clinic of 13 tertiary hospitals in China from February to September 2022. ID Migraine questionnaire was applied to evaluate for migraine. Both univariable and multivariable logistic regression models were used to explore the influencing factors of migraine.ResultsA total of 1326 patients with epilepsy were enrolled in this study. The prevalence of migraine among patients with epilepsy was 19.2% (254/1326). In the multivariable analysis, being female (OR = 1.451, 95% CI: 1.068–1.975; p = 0.018), focal and focal to bilateral tonic–clonic seizures (OR = 1.583, 95% CI: 1.090–2.281; p = 0.015), and current seizure attack in the last 3 months (OR = 1.967, 95% CI: 1.282–3.063; p = 0.002) were the influencing factors for migraine. However, <10% of patients with epilepsy received analgesics for migraine.SignificanceApproximately 20% of patients with epilepsy screened positive for migraine. Being female, focal and focal to bilateral tonic–clonic seizures, and current seizure attack in the last 3 months were the influencing factors for migraine. Neurologists should pay more attention to the screening and management of the migraine among patients with epilepsy in China.Plain Language SummaryEpilepsy and migraine are common chronic neurological disease with shared pathophysiological mechanisms and therapeutic options. However, migraine is often underestimated among patients with epilepsy. This multicenter study aimed to evaluate the prevalence of migraine and current status of treatment. In this study, approximately 20% of patients with epilepsy screened positive for migraine. Female, focal and focal to bilateral tonic–clonic seizures, and current seizure attack in the last 3 months were identified as independent influencing factors for migraine. Despite the high prevalence, the treatment for migraine was not optimistic, neurologists should pay more attention to the screening and management of migraine.
The Impact of Combined Sewer Overflows on Pharmaceutical and Illicit Drug Levels in New York/New Jersey Waterways
Authors: Acosta Teeshavi , Chavez Viviana , Fernandez Natalie , Perry Erin , Good Kate , Concheiro Marta 
Published: May 2024

Abstract
Pharmaceuticals and drugs of abuse are organic micropollutants of emerging concern in both surface and groundwater worldwide. These compounds are considered to be pseudo-persistent because of their continuous release into water systems. The presence of these compounds in the environment at any concentration poses a potential risk to nontarget organisms. The main sources of these contaminants are wastewater treatment plants (WWTPs) and combined sewer overflows (CSOs). The primary goal of our study was to identify and quantify a panel of 28 commonly prescribed pharmaceuticals (mood-altering drugs, cardiovascular drugs, antacids, antibiotics) and high-prevalence drugs of abuse (cocaine, amphetamines, opioids, cannabis) in river water samples collected from 19 locations in the Hudson and East rivers in New York City. The second goal was to investigate the possible source (WWTP or CSOs) of these micropollutants. Samples were collected weekly from May to August 2021 (n = 224) and May to August 2022 (n = 232), and placed at −20 °C until analysis by liquid chromatography–tandem mass spectrometry. The most frequently detected analytes in 2021 were metoprolol (n = 206, 92%), benzoylecgonine (n = 151, 67%), atenolol (n = 142, 63%), and methamphetamine (n = 118, 53%), and in 2022 the most frequently detected were methamphetamine (n = 194, 84%), atenolol (n = 177, 76%), metoprolol (n = 177, 76%), and 2-ethylene-1,5-dimethyl-3,3-diphenylpyrrolidine (n = 159, 69%). Measured concentrations ranged from the limit of detection (0.50–5.00 ng/L) to 103 ng/L. More drugs and higher concentrations were detected in water contaminated by Enterococci (&gt;60 most probably number) and after rainfall, indicating the influence of CSOs. The presence of drugs in samples with little to no Enterococci and after dry weather events indicates that WWTPs contribute to the presence of these substances in the river, probably due to a low removal rate. Environ Toxicol Chem 2024;43:1592–1603. © 2024 SETAC
Fermented red rice improved the antioxidant activity, bioaccessibility of polyphenols, and lipid‐lowering activity in C. elegans
Authors: Zhu Ying , Zhang Yanshun , Qu Caixing , Bai Juan , Zhao Yansheng , Xiao Xiang 
Published: May 2024

AbstractRed rice is a kind of whole grain with health benefits. Probiotic fermentation is widely applied to promote nutrient release from cereals and improve bioactivity. The study aims to investigate the impact of Lactiplantibacillus plantarum (L. plantarum) dy‐1 fermentation on the bioactivities, bioaccessibility, and lipid‐lowering activities of red rice. Results indicated that fermentation significantly increased the protein and total phenolic content by 1.7 and 1.4 times of red rice, as well as the content of essential and nonessential amino acids. Fermentation remarkably increased the bioaccessibility of phenolics and the antioxidant capacity of red rice during in vitro digestion. Additionally, Caenorhabditis elegans study revealed that fermented red rice extract reduced the triglyceride content, alleviated fat deposition, and regulated lipid metabolism by altering the genes in the fatty acid oxidation and synthesis, such as daf‐16, mdt‐15, nhr‐49, fat‐5, fat‐7, and hosl‐1. Therefore, L. plantarum dy‐1 fermentation was beneficial for improving bioaccessibility and lipid‐lowering activities of red rice, which will provide a reference for utilization of red rice as a functional food.
Health literacy profiles of final year pre‐service teachers in two initial education programs compared with the general population: A cross‐sectional study using the Health Literacy Questionnaire
Authors: Peralta Louisa R. , Kealy‐Ashby Cassidy , Owen Katherine , Corbett Lucy 
Published: May 2024

AbstractIssue AddressedHealth literacy (HL) can be developed throughout the lifespan starting from the early years highlighting that educational institutions, curriculum and teachers are powerful settings, places and people that can foster HL in youth. Current research shows that Australian teachers need more support to teach health education that promotes students' HL, with limited research focusing on pre‐service teachers (PST). This study aims to identify the HL strengths and challenges of PST at one Australian university across two initial teacher education programs (HPE and primary) and compare their health literacy profiles with that of the Australian general population.MethodsThe Health Literacy Questionnaire (HLQ) was administered in March and April, 2022 to measure HL in Australian PST. The research setting was a university in Sydney, Australia, with two of the University's undergraduate initial teacher education (ITE) programs (Health and Physical Education [HPE] and Primary). Of the 24 PST in the HPE cohort, 23 consented. Of the 70 PST in the Primary cohort, 34 consented. The results were compared with Australian Bureau of Statistics data.ResultsThe participants' median age was 22.3(4.3) years (SD), age ranged from 20 to 54 years, with 36% of participants under the age of 22 years. When comparing the PST data with the general population there were two significant differences: (1) PST scored significantly higher than the general population for Domain 4 (Social support for health, 3.41 vs. 3.19; p < 0.001; d = 0.57); and (2) the PST scored significantly lower for Domain 9 (Understand health information enough to know what to do, 4.02 vs. 4.27; p < 0.01; d = −0.43). In addition, we found that primary PST had significantly lower scores for domains 5–9 (demonstrative of interactive and critical HL), compared with the general Australian population.ConclusionsFindings show that PST strengths are that they perceive that there they are able to access social support for health, however the PST find it more difficult to analyse and apply health information, compared with the general Australian population.So What?Further understanding of health literacy profiles of Australian PST should influence the design of ITE programs and its health education curricular to ensure that PST are able to further develop their HL understandings and capabilities.
Enhancement of anaerobic digestion of dairy wastewater by addition of conductive materials with or without the combination of external voltage application
Authors: Fountoulakis Michail S , Frkova Zuzana , Lemaigre Sébastien , Goux Xavier , Calusinska Magdalena , Roussel Jimmy 
Published: May 2024

AbstractBACKGROUNDThe addition of conductive materials or the application of external voltage is a promising novel methodology to enhance methane production in anaerobic digesters. However, there is limited knowledge about their individual or combined effects on the anaerobic digestion of dairy wastewater. The aim of this study was to examine the effects of granular activated carbon (GAC) or magnetite addition and external voltage application, both individually and in combination, for the anaerobic digestion of real, undiluted dairy wastewater.RESULTSThe results showed that the estimated maximum methane production rate increased significantly (P < 0.05) from 143 ± 8 mL gVSadded−1 day−1 in the control reactors to 163 ± 11 mL gVSadded−1 day−1 and 166 ± 11 mL gVSadded−1 day−1 in the reactors containing GAC, with or without the combination of external voltage, respectively. The addition of GAC, in both cases, resulted in higher consumption rate of acetate, indicating a promotion of the methanogenesis step. By contrast, the application of external voltage or the addition of magnetite had no significant effect on either methane production rate nor methane yield. Moreover, the analysis of the microbial community showed that the addition of GAC resulted in the enrichment of Desulfobacterota, Methanosarcina, Candidatus Methanofastidiosum and Methanolinea.CONCLUSIONOverall, GAC addition seems a promising strategy to increase methane production in anaerobic digesters treating dairy wastewater. © 2024 The Author(s). Journal of Chemical Technology and Biotechnology published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry (SCI).
The impact of virtual reality simulation on dental education: A systematic review of learning outcomes and student engagement
Authors: Algarni Youssef Abdullah , Saini Ravinder S. , Vaddamanu Sunil Kumar , Quadri Syed Altafuddin , Gurumurthy Vishwanath , Vyas Rajesh , Baba Suheel Manzoor , Avetisyan Anna , Mosaddad Seyed Ali , Heboyan Artak 
Published: May 2024

AbstractPurposeVirtual reality (VR) simulations have been increasingly employed to train dental students prior to clinical practice. According to the literature, blended learning designs in the form of VR simulations can be utilized by both dental students and instructors to provide quality education. They can also save time and improve motor skills before students enter clinical stages. Therefore, this study was designed to review the importance of available VR simulators and their impact on student learning and outcomes.MethodThe Preferred Reporting Items for Systematic Reviews and Meta‐Analysis guidelines were followed to review the literature systematically, and different databases such as PubMed, ScienceDirect, Cochrane Library, Scopus, and Google Scholar were searched (up to December 2023) for relevant articles using keywords: “virtual reality,” “virtual reality simulators,” “virtual reality simulation,” and “dental education.” The Mixed Methods Appraisal Tool was used to assess the study quality.ResultsAfter a comprehensive literature search, 1477 research articles were identified, of which 16 were included in the present study. In terms of students’ learning outcomes, engagement, and optimal approach, a significant improvement was observed compared to conventional training methods, specifically in their knowledge, performance, confidence, and psychomotor skills.ConclusionThe findings suggest that VR simulators enhance the overall learning abilities of dental students and should be regarded as an integral component of the current curriculum. However, it is important to recognize that VR simulators cannot fully substitute traditional training methods; rather, they can effectively complement them.
Analysis of B‐cell receptor repertoire to evaluate immunogenicity of monovalent Omicron XBB.1.5 mRNA vaccines
Authors: Funakoshi Yohei , Yakushijin Kimikazu , Ohji Goh , Matsutani Takaji , Doi Kazuhiko , Sakai Hironori , Sasaki Tomoki , Kusakabe Takahiro , Matsumoto Sakuya , Saito Yasuyuki , Kawamoto Shinichiro , Yamamoto Katsuya , Koyama Taiji , Nagatani Yoshiaki , Kurata Keiji , Kimbara Shiro , Imamura Yoshinori , Kiyota Naomi , Ito Mitsuhiro , Minami Hironobu 
Published: May 2024

AbstractMonovalent Omicron XBB.1.5 mRNA vaccines were newly developed and approved by the FDA in Autumn 2023 for preventing COVID‐19. However, clinical efficacy for these vaccines is currently lacking. We previously established the quantification of antigen‐specific antibody sequence (QASAS) method to assess the response to severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) vaccination at the mRNA level using B‐cell receptor (BCR) repertoire assay and the coronavirus antibody database (CoV‐AbDab). Here, we used this method to evaluate the immunogenicity of monovalent XBB.1.5 vaccines. We analyzed repeated blood samples of healthy volunteers before and after monovalent XBB.1.5 vaccination (BNT162b2 XBB.1.5 or mRNA‐1273.815) for the BCR repertoire to assess BCR/antibody sequences that matched SARS‐CoV‐2‐specific sequences in the database. The number of matched unique sequences and their total reads quickly increased 1 week after vaccination. Matched sequences included those bound to the Omicron strain and Omicron XBB sublineage. The antibody sequences that can bind to the Omicron strain and XBB sublineage revealed that the monovalent XBB.1.5 vaccines showed a stronger response than previous vaccines or SARS‐CoV‐2 infection before the emergence of XBB sublineage. The QASAS method was able to demonstrate the immunogenic effect of monovalent XBB.1.5 vaccines for the 2023–2024 COVID‐19 vaccination campaign.