bluuebunny/crossref_metadata_2025_split huggingface dataset:
Transcranial direct current stimulation does not modulate motor cortex excitability in patients with amyotrophic lateral sclerosis
Authors: Munneke Moniek A.M. , Stegeman Dick F. , Hengeveld Yvonne A. , Rongen Jan J. , Schelhaas H. Jurgen , Zwarts Machiel J. 
Published: January 2011

AbstractIntroduction:Amyotrophic lateral sclerosis (ALS) is a progressive disease caused by the degeneration of upper and lower motor neurons. The etiology of ALS is unclear, but there is evidence that loss of cortical inhibition could be related to motor neuron degeneration. We sought to determine whether cathodal transcranial direct current stimulation (tDCS) can reduce cortical excitability in patients with ALS.Methods:Three sessions of cathodal tDCS, lasting 7, 11, or 15 minutes, were performed in 10 patients and 10 healthy controls. Corticospinal excitability was measured before and after the tDCS.Results:Cathodal tDCS induced a consistent decrease in corticospinal excitability in healthy controls, but not in ALS patients.Conclusions:The failure of tDCS to produce an excitability shift in the patients supports the potential diagnostic value of tDCS as a marker of upper motor neuron involvement. However, variation in corticospinal excitability measurements both inter‐ and intraindividually will limit its usefulness. Muscle Nerve 44: 109–114, 2011
Clarifying variability of corticomotoneuronal function in kennedy disease
Authors: Vucic Steve , Kiernan Matthew C. 
Published: January 2011

AbstractIntroduction:Although Kennedy disease (KD) is regarded as a pure lower motor neuron disorder, recent transcranial magnetic stimulation (TMS) studies have reported subclinical corticomotoneuronal dysfunction in KD. To clarify these findings, this study applied novel triple stimulation (TST) and threshold tracking TMS techniques to gain further insights into corticomotoneuronal function in KD.Methods:TMS studies were undertaken in 12 KD patients and 38 age‐matched controls. Motor evoked potentials were recorded over the abductor pollicis brevis (threshold tracking TMS) and abductor digiti minimi (TST).Results:The mean TSTtest:TSTcontrol amplitude (99 ± 0.7%, normal >93%) and area (98.4 ± 1.6%, normal >92%) ratios were normal in Kennedy disease. In addition, short‐interval intracortical inhibition (SICI) was similar in KD and controls (KD: 8.1 ± 1.3%; controls: 10.1 ± 0.7%; P = 0.11), as were the motor evoked potential amplitude, resting motor threshold, intracortical facilitation, and cortical silent period duration.Conclusions:Triple stimulation and threshold tracking TMS techniques have reiterated normal corticomotoneuronal function in KD. Muscle Nerve, 2011
Succinylcholine in malignant hyperthermia: Evaluation of a novel in vivo model
Authors: Metterlein Thomas , Schuster Frank , Palmer Elise , Roewer Norbert , Anetseder Martin 
Published: January 2011

AbstractIntroduction:Malignant hyperthermia (MH) is a potentially lethal anesthetic complication characterized by muscle hypermetabolism and generalized rigor. The exact mechanism of succinylcholine as an MH trigger cannot be examined in existing in vitro models. Therefore, a novel in vivo model was used to examine the metabolic response to succinylcholine.Methods:With institutional review board approval, 6 MH susceptible (MHS) and 6 MH non‐susceptible (MHN) pigs were anesthetized with hemodynamic and systemic metabolic monitoring. Microdialysis catheters were placed intramuscularly. After equilibration, succinylcholine, halothane, and Ringer solution were injected. Lactate was measured in the dialysate and statistically analyzed by Mann–Whitney U‐test (significance level P < 0.05).Results:Hemodynamic and systemic metabolic parameters were not different between the groups throughout the experiment. In the MHS pigs, halothane induced a significant increase of lactate. In MHN pigs, no substance induced a reaction.Conclusions:Halothane, but not succinylcholine, induced a hypermetabolic reaction in this model. Therefore, the role of succinylcholine as an MH trigger remains questionable. Muscle Nerve, 2011
Electrophysiological features of hirayama disease
Authors: Lyu Rong‐Kuo , Huang Ying‐Chih , Wu Yih‐Ru , Kuo Hung‐Chou , Ro Long‐Sun , Chen Chiung‐Mei , Chang Hong‐Shiu 
Published: January 2011

AbstractIntroduction: The purpose of this study was to compare the pattern of hand muscle involvement in Hirayama disease (HD) and amyotrophic lateral sclerosis (ALS). Methods: We reviewed findings of upper limb nerve conduction studies of 46 HD patients and 60 ALS patients. The findings from 54 healthy subjects were used for comparison. Results: In HD, the ulnar compound muscle action potential (CMAP) amplitude was more severely reduced than the median one, and the reverse pattern was observed in ALS. The mean ulnar/median (U/M) CMAP amplitude ratio was significantly lower in HD (0.64 ± 0.79) and abnormally higher in ALS (2.15 ± 1.77) compared with normal subjects (0.89 ± 0.23). An abnormally low U/M CMAP amplitude ratio (<0.6) was encountered in 34 patients with HD and in 1 with ALS. A U/M CMAP amplitude ratio ≥4.5 or absent median motor response was found only in ALS. Conclusion: Our findings demonstrate different patterns of hand muscle involvement between these two diseases. Muscle Nerve, 2011
The effect of paired stimuli on blink reflex latencies in normal subjects
Authors: Rubin Devon I. , Dimberg Elliot L. , Kennelly Kathleen D. 
Published: January 2011

AbstractIntroduction: In this study we assessed the effect of paired stimuli on the latencies and amplitudes of the blink reflex. Methods: Blink reflexes were performed with single and paired (5‐ms interstimulus interval) stimuli in 47 patients. The changes in latencies between paired and single stimuli were calculated. Results: Paired stimulation produced two types of R1 waveform morphologies: single‐ and double‐peaked waveforms. Increases in R1 and contralateral R2 latencies with paired stimulation were significantly higher in those with single‐peaked R1 responses compared to those with double‐peaked R1 responses. Conclusions: Interpreting the blink reflex latencies using paired stimulation requires visualization of the R1 waveform morphology. A double‐peaked R1 response requires no change in normal latency values, but the latency of a single‐peaked R1 should be interpreted from the second shock artifact. The effect on the R2 latency is variable. Muscle Nerve, 2011
Peripheral nerve and muscle ultrasound in amyotrophic lateral sclerosis
Authors: Cartwright Michael S. , Walker Francis O. , Griffin Leah P. , Caress James B. 
Published: January 2011

AbstractIntroduction:High‐resolution ultrasound has been used to evaluate several neuromuscular conditions, but it has only been used on a limited basis in amyotrophic lateral sclerosis (ALS) patients. It has not been used to assess their peripheral nerves. This study was designed to use neuromuscular ultrasound to investigate nerve cross‐sectional area and muscle thickness in ALS.Methods:Twenty individuals with ALS and 20 matched controls underwent neuromuscular ultrasound to measure the cross‐sectional area of their median and sural nerves and the thickness of their biceps/brachialis muscle complex.Results:The cross‐sectional area of the median nerve in the mid‐arm was smaller in the ALS group than in controls (10.5 mm2 vs. 12.7 mm2, P = 0.0023), but no difference was seen in the sural nerve (4.5 mm2 vs. 5.0 mm2, P = 0.1927). The ALS group also had thinner biceps/brachialis than controls (2.1 cm vs. 2.9 cm, P = 0.0007).Conclusions:Neuromuscular ultrasound demonstrates nerve and muscle atrophy in ALS and should be further explored as a disease biomarker. Muscle Nerve 44: 346–351, 2011
Incidence of stress urinary incontinence following vaginal repair of pelvic organ prolapse in objectively continent women
Authors: Al‐Mandeel Hazem , Ross Sue , Robert Magali , Milne Jill 
Published: January 2011

AbstractObjective To estimate the incidence of stress urinary incontinence (SUI) following vaginal repair of pelvic organ prolapse (POP) in preoperatively continent women and to evaluate the impact of the problem.Methods Women were eligible if they had undergone vaginal repairs for any degree or type of POP with no anti‐incontinence procedure between July 1, 2004 and June 30, 2006, and had been continent preoperatively, as defined by a negative cough stress test with or without reduction of prolapse. Demographic, preoperative, operative, and postoperative data were retrieved from hospital charts. The incidence of postoperative SUI (POSUI) and its quality of life (QoL) impact were assessed by mailed questionnaire. The POSUI endpoint was defined by the report of SUI symptoms on the mailed questionnaire and/or affirmation of postoperative treatment for SUI.Results Forty‐two out of 100 respondents reported POSUI within the 2‐year average follow‐up period. Twelve of 37 symptomatic women (32%) were moderately or greatly bothered by their symptoms. The QoL impact score was generally low but was statistically greater in women with POSUI compared to those with no POSUI (13 vs. 3, P = 0.0006).Conclusion The risk of POSUI following vaginal repairs of POP may be higher than previously reported and approximately one‐third of women are bothered by these symptoms. These findings deserve further investigation. Neurourol. Urodynam. 30:390–394, 2011. © 2011 Wiley‐Liss, Inc.
Incontinence improves in older women after intensive pelvic floor muscle training: An assessor‐blinded randomized controlled trial
Authors: Sherburn Margaret , Bird Margaret , Carey Marcus , Bø Kari , Galea Mary P. 
Published: January 2011

AbstractAimsTo test the hypotheses that high intensity pelvic floor muscle training (PFMT) is effective in relief of stress urinary incontinence in community dwelling older women, and that intense PFMT improves stress urinary incontinence more than bladder training (BT) in this population.MethodsA two‐center, assessor‐blinded randomized controlled trial of 20 weeks duration with two active intervention arms: PFMT and BT. Assessments and interventions were undertaken at two metropolitan tertiary hospitals. Participants were community dwelling women over 65 years of age with urodynamic stress incontinence. Primary outcome measure was urinary leakage during a cough stress test. Secondary outcome measures included symptoms and bother (ICIQ‐UI SF), participant global perception of change, leakage episodes (7‐day accident diary), degree of “bother” (VAS) and health related quality of life (AQoL).ResultsEighty‐three Caucasian women, 71.8 (SD 5.3) years participated in the study. Both groups improved over the intervention period; however, the PFMT group reported significantly lower amounts of leakage on the stress test [PFMT median 0.0 g, 95% CI: 0.2–0.9; BT median 0.3 g, 95% CI: 0.2–1.7, P = 0.006], improved symptoms and bother [PFMT mean 5.9, 95% CI: 4.8–7.1; BT group mean 8.5, 95% CI: 7.1–9.9 and greater perception of change [PFMT 28 (73.6%); BT 12 (36.4%) (P = 0.002)] after 5 months than the BT group.ConclusionsHigh intensity PFMT is effective in managing stress urinary incontinence and is more effective than BT in healthy older women. Neurourol. Urodynam. 30:317–324, 2011. © 2011 Wiley‐Liss, Inc.
Quality of life in elderly men with aging symptoms and lower urinary tract symptoms (LUTS)
Authors: Perchon Lygia F.G. , Pintarelli Vitor L. , Bezerra Edson , Thiel Marcelo , Dambros Miriam 
Published: January 2011

AbstractAimsThe aims of this study were to investigate quality of life (QoL) due to physical and psychological changes occurring in elderly men and to identify associated factors between lower urinary tract symptoms (LUTS) and aging male symptoms (ADAM).Materials and MethodsThis was a case–control study whereby 200 elderly men were recruited from the community and the Urology and Geriatrics ambulatories. Subjects were asked to fill out the Aging Male Symptoms Scale (AMS), World Health Organization Quality of Life‐BREF and ‐OLD, and IPSS questionnaires. Participants were classified in two groups according to IPSS: group I (moderate to severe symptoms) and group II (mild symptoms).ResultsThe AMS scale and both QoL questionnaires of group I showed significantly worse median scores in all parameters. The average somatic and sexual subscore was significantly higher in group I (P < 0.0005). The social and environmental domains presented the most significant differences (P < 0.0005) in both questionnaires, and the mean of the WHOQOL‐OLD score was significantly lower in group I (P < 0.0005).ConclusionsModerate to severe ADAM and LUTS impact significantly all parameters of HRQOL and generic QoL proposed by the WHO. There was correlation between severity of LUTS and severity of the following ADAM: depression, feeling burnt out, decline of feeling of general well‐being, joint and body complaints, insomnia, weakness of muscles, feeling that the peak had passed, decrease of sexual performance, and decrease of morning erections. 30:515–519, 2011. © 2011 Wiley‐Liss, Inc.
Brain response provoked by different bladder volumes: A near infrared spectroscopy study
Authors: Matsumoto Shinya , Ishikawa Akira , Matsumoto Shinichi , Homma Yukio 
Published: January 2011

AbstractAimsIn order to understand frontal lobe responses in bladder sensation in healthy subjects, we examined the cortical localization of response to the different bladder volumes.MethodsFrontal blood flow was measured non‐invasively in 24 resting adults using multi‐channel near infrared spectroscopy (NIRS). Changes in bladder volume were induced by infusing and releasing water from the bladder. Two states of bladder sensation have been induced, “first desire to void” and “strong desire to void.ResultsNIRS analysis revealed that cerebral responses to bladder sensation were associated with increased levels of oxy‐hemoglobin in the bilateral frontal cortex. The responses became stronger in the state of strong desire to void at enlarged bladder volume (P < 0.01). These results indicate that bilateral frontal areas are involved in bladder perception related to increased urine volumes in adults.ConclusionsThe dynamic changes in cerebral blood oxygenation were similar to those assessed in other methodologies such as f‐MRI and PET. This result suggests that NIRS study might be available for investigating the mutual relationship between bladder and brain in patients suffering from neurological problems and urinary tract symptoms. 30:529–535, 2011. © 2011 Wiley‐Liss, Inc.
The association of changes in opening detrusor pressure with the resolution of overactive bladder symptoms after repair of pelvic organ prolapse
Authors: Basu Maya , Duckett Jonathan 
Published: January 2011

AbstractAimsTo evaluate whether changes in opening detrusor pressure (ODP) are associated with resolution of overactive bladder symptoms in women undergoing surgical correction of pelvic organ prolapse.MethodsForty women with DO and OAB together with anterior wall prolapse who underwent a repair between 2003 and 2007 were studied. Each woman was assessed pre‐ and post‐operatively with a clinical assessment and cystometry. Opening pressures were recorded pre‐ and post‐operatively for each patient by retrospective review of the pressure flow traces. Patients were divided into those who experienced resolution of OAB symptoms and those with persistent OAB symptoms. Wilcoxon matched pairs signed rank test was used to assess any change in opening pressures between these groups.ResultsResolution of urgency with an anterior repair was associated with a significant fall in ODP from a mean of 27.9 to 11.7 cmH2O (P = 0.01). There was no significant pre‐operative difference in ODP between women in whom urgency resolved and those in whom it did not.ConclusionThese results suggest that a fall in ODP is associated with resolution of urgency in women undergoing prolapse surgery. This may imply that decreased urethral resistance is of importance in symptom resolution. 30:595–598, 2011. © 2011 Wiley‐Liss, Inc.
A decomposition for total‐coloring partial‐grids and list‐total‐coloring outerplanar graphs
Authors: Machado Raphael C. S. , de Figueiredo Celina M. H. 
Published: February 2011

AbstractThe total chromatic number χT(G) is the least number of colors sufficient to color the elements (vertices and edges) of a graph G in such a way that no incident or adjacent elements receive the same color. In the present work, we obtain two results on total‐coloring. First, we extend the set of partial‐grids classified with respect to the total‐chromatic number, by proving that every 8‐chordal partial‐grid of maximum degree 3 has total chromatic number 4. Second, we prove a result on list‐total‐coloring biconnected outerplanar graphs. If for each element x of a biconnected outerplanar graph G there exists a set Lx of colors such that |Luw| = max{deg(u) + 1, deg(w) + 1} for each edge uw and |Lv| = 7 − δdeg(v),3 − 2δdeg(v),2 (where δi,j = 1 if i = j and δi,j = 0 if i ≠ j) for each vertex v, then there is a total‐coloring π of graph G such that π(x) ∈ Lx for each element x of G. The technique used in these two results is a decomposition by a cutset of two adjacent vertices, whose properties are discussed in the article. © 2011 Wiley Periodicals, Inc. NETWORKS, 2011
Periostitis and osteolysis in a medieval skeleton from South‐West Hungary: (Leprosy, treponematosis, tuberculosis or hypertrophic osteoarthropathy) A diagnostic challenge!
Authors: Christensen Tina , Martínez‐Lavín Manuel , Pineda Carlos 
Published: January 2011

ABSTRACTThis paper uses macroscopic and radiological examinations to provide differential diagnoses of pathological lesions in the well‐preserved skeleton of a young male from the medieval site of Zalavár in South‐West Hungary. Macroscopic inspection of the skeleton revealed conspicuous thickening of the tibiae and fibulae with ‘tree bark’ appearance of the cortex. Periosteal proliferations are also found on the calcanea and on the posterior part of the femora. The metatarsals showed bony proliferation and bone dissolution. No alteration of the axial skeleton or the skull was noted. Radiographs showed thickening of the cortex of tubular bones due to a multilayered type of periosteal apposition. The likelihood of these symptoms being the result of melorheostosis, hypervitaminosis A, fluorosis, thyroid acropachy, endosteal hyperostosis, tuberculosis (TB), hypertrophic osteoarthropathy (HOA), treponematosis and leprosy is reviewed. None completely explains the entire spectrum of pathological lesions in the current individual, but the individual may have suffered from two co‐existent diseases. As a clinical entity, the changes in the metatarsals are compatible with leprosy, whereas the periosteal proliferations of the lower limbs point to a diagnosis of HOA as a secondary syndrome. Thus, a combination of leprosy and TB is suggested as a potential diagnosis. Although not definitive, our differential diagnosis was able to exclude a number of conditions producing periosteal apposition. Copyright © 2011 John Wiley & Sons, Ltd.
The biological and clinical impact of inhibition of NF‐κB‐initiated apoptosis in diffuse large B cell lymphoma (DLBCL)
Authors: Bavi Prashant , Uddin Shahab , Bu Rong , Ahmed Maqbool , Abubaker Jehad , Balde Valorie , Qadri Zeeshan , Ajarim Dahish , Al‐Dayel Fouad , Hussain Azhar R , Al‐Kuraya Khawla S. 
Published: February 2011

AbstractNF‐κB is frequently over‐expressed in a variety of non‐Hodgkin's lymphomas (NHLs) and has been implicated in lymphomagenesis; however, its role in diffuse large B cell lymphoma (DLBCL) as a prognostic biomarker has not been fully elucidated. Therefore, we investigated the role of NF‐κB and its association with clinicopathological features in a tissue microarray cohort of 230 DLBCL patient samples. We then elucidated the role of NF‐κB inhibition on cell viability and apoptosis in vitro, using DLBCL cell lines. Using immunohistochemistry, NF‐κB was detected in 25.6% (52/203) DLBCL tumours, was associated with activated B cell (ABC) phenotype (p = 0.0054), Epstein–Barr virus (EBV; p = 0.0080) and over‐expression of the anti‐apoptotic marker XIAP (p = 0.0013). DLBCL cases with nuclear expression of NF‐κB showed a significantly poorer overall survival as compared to those without NF‐κB expression (p = 0.0236). In a multivariate analysis using a Cox proportional hazard model for IPI and NF‐κB expression, the relative risk was 2.97 for high NF‐κB expression (95% CI 1.27–6.94; p = 0.0113) and 7.55 for the high‐IPI group (95% CI 3.34–18.35; p < 0.0001). In vitro, Bay 11‐7085 inhibited constitutively active NF‐κB expression in a dose‐dependent manner and inhibition of NF‐κB also down‐regulated expression of the downstream target gene products Bcl‐2, Bcl‐XL (BCL2L1), XIAP and Survivin, leading to apoptosis via activation of the mitochondrial apoptotic pathway. NF‐κB over‐expression was found to be an independent prognostic marker for poor survival in DLBCL. Altogether, these results suggest that NF‐κB may be a useful prognostic biomarker and a potential target for therapeutic intervention in DLBCL. Copyright © 2011 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
Cytomegalovirus sinusitis in a child with chronic myelogenous leukemia following bone marrow transplantation
Authors: Rayes Ahmad , Sahni Kiren , Hanna Christian , Suryadevara Manika , Goyal Parul , Cherrick Irene 
Published: February 2011

AbstractCytomegalovirus (CMV) is a common opportunistic pathogen. CMV sinusitis has been described in acquired immunodeficiency syndrome (AIDS) patients, but not in other immune compromising conditions. In this report, we describe CMV sinusitis in a child with chronic myelogenous leukemia (CML) following bone marrow transplantation. Pediatr Blood Cancer 2011;56:1140–1142. © 2011 Wiley‐Liss, Inc.
Water absorption behavior of PALF/GF hybrid polyester composites
Authors: Devi L. Uma , Bhagawan S.S. , Nair K.C. Manikandan , Thomas S. 
Published: February 2011

AbstractThe water absorption characteristics of pineapple leaf fiber (PALF)/glass fiber (GF) hybrid polyester(PER) composites, and chemically modified PALF/polyester composites were evaluated by immersion in distilled water at 28, 60, and 90°C. The diffusion properties of the intimately mixed (IM) and the layered hybrid composite GPG (Glass skin and PALF core) of different PALF/GF ratio at the three temperatures were compared in order to identify the environmental ageing mechanism at different temperatures. The effect of temperature on the kinetics and thermodynamics of diffusion were also examined. The water uptake of both IM and GPG hybrid composites was decreased with increase in glass fiber content; the lowest water uptake was observed for 0.46 Vf GF hybrid composite. Among the chemically modified composites, vinyl tri 2‐methoxy ethoxy silane treated composites showed the lowest water uptake. Finally, parameters like diffusion, sorption, and permeability coefficients were determined. It was observed that equilibrium water uptake is dependent on the nature of the composite and temperature. Experimental results were also compared with theoretical predictions. POLYM. COMPOS., 2011. © 2011 Society of Plastics Engineers