bluuebunny/crossref_metadata_2025_split huggingface dataset:
Independent Association Between Obstructive Sleep Apnea Severity and Glycated Hemoglobin in Adults Without Diabetes
Authors: Priou Pascaline , Le Vaillant Marc , Meslier Nicole , Chollet Sylvaine , Masson Philippe , Humeau Marie P. , Pigeanne Thierry , Bizieux-Thaminy Acya , Goupil François , Gagnadoux Frédéric ,   The IRSR Sleep Cohort Group
Published: June 2012

OBJECTIVE
We tested the hypothesis of an independent cross-sectional association between obstructive sleep apnea (OSA) severity and glycated hemoglobin (HbA1c) in adults without known diabetes.

RESEARCH DESIGN AND METHODS
HbA1c was measured in whole-blood samples from 2,139 patients undergoing nocturnal recording for suspected OSA. Participants with self-reported diabetes, use of diabetes medication, or HbA1c value ≥6.5% were excluded from this study. Our final sample size comprised 1,599 patients.

RESULTS
A dose-response relationship was observed between apnea-hypopnea index (AHI) and the percentage of patients with HbA1c &gt;6.0%, ranging from 10.8% for AHI &lt;5 to 34.2% for AHI ≥50. After adjustment for age, sex, smoking habits, BMI, waist circumference, cardiovascular morbidity, daytime sleepiness, depression, insomnia, sleep duration, and study site, odds ratios (95% CIs) for HbA1c &gt;6.0% were 1 (reference), 1.40 (0.84–2.32), 1.80 (1.19–2.72), 2.02 (1.31–3.14), and 2.96 (1.58–5.54) for AHI values &lt;5, 5 to &lt;15, 15 to &lt;30, 30 to &lt;50, and ≥50, respectively. Increasing hypoxemia during sleep was also independently associated with the odds of HbA1c &gt;6.0%.

CONCLUSIONS
Among adults without known diabetes, increasing OSA severity is independently associated with impaired glucose metabolism, as assessed by higher HbA1c values, which may expose them to higher risks of diabetes and cardiovascular disease.
Crystal growth of organic energetic materials: pentaerythritol tetranitrate
Authors: Zhang Gengxin , Weeks Brandon , Zhang Xin 
Published: June 2012

Abstract
The energy output performance and thermal stability of organic energetic materials have a strong dependence on the porosity, particle morphology, and micro-scale crystal structure. This paper reviews the growth habit of pure pentaerythritol tetranitrate (PETN) crystals and the effect of metal impurities on microcrystal morphology of PETN films. The pure crystal growth shows that PETN molecules diffuse on the surface and nucleate in a two-dimensional layer-by-layer fashion; the final structure is controlled by the deposition flux. Also, the effect of metal cation impurities has a strong impact on the thermal stability and crystal structure, and is dependent on the doping level.
Effects of different fatty acid supplementation on body weight and haematobiochemical parameters in rat
Authors: Rahman MA , Jahan M , Karmaker S , Islam MK 
Published: June 2012

The effects of some selected fatty acids supplement on hematobiochemical parameters were studied in rat. A total of twenty rats were randomly assigned into four groups. Group A was considered as control and fed with rat pellet. Group B was treated with 20 mg Soybean oil / kg feed, group C with 20 mg Mustard oil/ kg feed and group D with 20 mg Ghee /kg feed. The mean body weight of group B, C and D of 2nd and 3rd observation (30 and 60 days, respectively) was significantly (P> 0.01) higher compared to group A (Control). The highest body weight was observed in 3rd observation and it was 185.00 ± 2.76 g in group D and the lowest was in control group. TLC value of group D increased significantly (P<0.01) compared to control and was also found higher for group of B and C than that of control. Similar results were found for PCV value. DLC value was significant for none of the groups. The serum cholesterol level of group D increased significantly (P<0.01) but it was also found higher for the groups B and C than that of control. Similar results were found for blood glucose level and Serum Glutamic Pyruvic Transaminase (SGPT) where the values of group D increased significantly (P<0.01) compared to control and the values were also found higher for the groups B and C than that of control. DOI: http://dx.doi.org/10.3329/ijns.v2i1.10879 International Journal of Natural Sciences (2012), 2(1): 21-25
Physicochemical and microbial water quality of Sylhet city corporation, Bangladesh
Authors: Hoque M , Ahmed S , Alam MJ , Purkayastha M , Belal A , Anwar MA 
Published: June 2012

Sylhet City Corporation (SCC) of Bangladesh is supplying water to the Sylhet city dwellers through its distribution network. The quality of water is at risk to deteriorate during its flow through the distribution system and also due to probability of high elemental concentrations in groundwater. To identify such probable water contamination problems; water samples from 20 (out of 27) different wards of the city were analyzed in this study. The parameters analyzed were pH, turbidity, total alkalinity as Calcium carbonate CaCO3, total hardness, iron, manganese, arsenic, chloride, fluoride, MPN (Most Probable Number), total viable count (TVC), coliform and fecal coliform. The study revealed that all the physico-chemical parameters except alkalinity were in the permissible limit. All the samples were found to have total alkalinity as CaCO3 value higher than the WHO and Bangladesh Standards limit. But the water from treatment plant was found to have high turbidity and iron concentration. Analysis of microbial water quality parameters revealed that there was no coliform and fecal coliform contamination. But high value of MPN index and total viable count indicates that there were obvious contamination and chances of contamination by non-fecal pathogens. Finally, it is concluded and recommended that the water treatment facilities of SCC have to be improved, further investigation should be done to identify the non-fecal organisms and the cause of high total viable bacteria should be detected and corrected for the betterment of the city dwellers. DOI: http://dx.doi.org/10.3329/ijns.v2i1.10881 International Journal of Natural Sciences (2012), 2(1): 33-37
In vitro Mass Propagation of a Ground Orchid - Phaius tancarvilleae (L'Her.) Blume through Shoot Tip Culture
Authors: Pant Bijaya , Shrestha Sumitra 
Published: June 2012

High frequency direct shoot proliferation was induced from the shoot tip explants derived from the in vitro grown seedlings of a critically endangered and horticulturally important ground orchid Phaius tancarvilleae (L'Her) Blume. Shoot tip explants cultured on solidified MS with alone or combination of various concentrations of NAA and BAP produced shoots and multiple shoots. The maximum number of healthy shoots was observed on MS with BAP (1.0 mg/l) with an average of 13.3 shoots per culture in 20 weeks; where shoot multiplication was initiated after 4 weeks of culture. Regenerated shoots rooted on MS with various concentrations of NAA, IAA, IBA. MS with NAA (0.5 mg/l) was the most appropriate condition for rooting. The well developed in vitro rooted plantlets were hardened successfully in the potting mixture containing cocopeat and sphagnum moss in the ratio of 2 : 1. Key words: Mass propagation, Phaius tancarvilleae, shoot multiplication D. O. I. 10.3329/ptcb.v21i2.10241 Plant Tissue Cult. & Biotech. 21(2): 181-188, 2011 (December)
Faire une thèse d'analyse du discours « troisième génération »
Authors: Florea Marie-Laure 
Published: June 2012

Cet article s’inscrit dans une double perspective, à cheval entre épistémologie et empirisme : j’y propose en parallèle une présentation de mes recherches et une réflexion sur leur place au sein de l’analyse du discours, en diachronie (je montre comment mon travail se situe par rapport à l’héritage des générations précédentes d’analystes du discours) et en synchronie (je réfléchis à la place de mes recherches par rapport aux différents courants qui se partagent le champ de l’AD contemporaine). Dans un premier temps, je me penche sur la façon dont mes recherches s’inscrivent dans le champ de l’AD, entre appropriation d’un héritage (au travers de la façon de concevoir l’objet de recherche, par le biais du cadre théorique, dans la préoccupation épistémologique) et innovation (notamment grâce au recours à un corpus inédit – les nécrologies de presse –, à la passerelle que je dresse entre linguistique et anthropologie, renouvelant la transdisciplinarité chère à l’AD, et à l’analyse de formes discursives nouvelles telles que la polysémioticité ou le texte tabulaire). Dans une seconde partie, je précise mon positionnement au sein du champ de l’analyse du discours : je revendique une conception étendue et radicale de l’énonciation, que je défends au travers de l’analyse de quelques exemples, qui me permettent de montrer que l’énonciation, loin d’être une composante de la textualité parmi d’autres, peut être envisagée comme une porte d’accès privilégiée au discours, dans la mesure où elle fonctionne en synergie avec l’ensemble des composantes du discours. Je montre enfin au travers du prisme de ma recherche en quoi l’AD contemporaine est susceptible de faire fructifier l’héritage de l’AD en revisitant le paradigme énonciatif, notamment en ce qui concerne le dialogisme, l’interpellation, et la textualité tabulaire.
Discours rapportés et stratégies argumentatives : Royal et Sarkozy lors du débat de l'entre-deux tours
Authors: Sandré Marion 
Published: June 2012

Cet article en analyse du discours française propose d’analyser les différences d’utilisation du discours rapporté par Ségolène Royal et Nicolas Sarkozy dans le débat de l’entre-deux tours de l’élection présidentielle française de 2007. Trois types de discours rapporté sont distingués : rapporter son propre discours, rapporter le discours de l’interlocuteur, et rapporter le discours d’un tiers. L’analyse montre comment ces différents procédés discursifs sont utilisés par chacun des candidats et quelles sont les stratégies argumentatives mises en œuvre par ces utilisations. On notera que le premier type de discours rapporté – l’autocitation – est surtout utilisé par Ségolène Royal pour affirmer sa constance et sa détermination : ce procédé citatif entre dans la stratégie de valorisation de son image. Le second type de discours rapporté – citer le discours de l’autre – est utilisé par les deux candidats et répond à deux visées : la visée convergente (être d’accord avec le discours de l’autre) et la visée divergente (s’opposer au discours de l’autre). Ce second objectif est surtout employé par Nicolas Sarkozy, à des fins très polémiques : la stratégie argumentative est clairement de critiquer les positions de l’adversaire. Enfin, le troisième type de discours rapporté – citer le discours d’un tiers – est utilisé par les deux candidats, afin de se positionner par rapport aux discours en circulation lors de la campagne présidentielle. On voit ainsi que les procédés citatifs sont très présents dans le débat et qu’ils sont utilisés différemment par les deux candidats. Les discours rapportés entrent bien dans les stratégies argumentatives propres au genre débat, selon les deux objectifs : autopromotion/critique de l’autre.
Successful Treatment of Aggressive Aneurysmal Bone Cyst of the Pelvis With Serial Embolization
Authors: Rossi Giuseppe , Mavrogenis Andreas F. , Papagelopoulos Panayiotis J. , Rimondi Eugenio , Ruggieri Pietro 
Published: June 2012

Intralesional surgery is most commonly used for aneurysmal bone cysts. Rarely is en bloc resection used for active, aggressive, recurrent lesions and those located in expendable bones. However, persistence or recurrence of aneurysmal bone cysts is common. The clinical behavior of aneurysmal bone cysts is more aggressive in younger patients. Selective embolization is used as the primary treatment for aneurysmal bone cysts in surgically difficult anatomical locations and as an adjuvant to surgical treatment to reduce intraoperative blood loss and facilitate curettage.
This article describes a 3-year-old boy with an aggressive aneurysmal bone cyst of the pelvis involving the right ischiopubic rami that achieved curative treatment with 3 embolizations with N-2-butyl-cyanoacrylate. Biopsy was diagnostic; however, the clinical course was misleading. Twenty days after the first embolization, despite complete occlusion of the feeding vessels, the patient experienced severe pain, increased size of the lesion, and lateral subluxation of the right hip. Based on the imaging and histological diagnosis, intralesional hemorrhage was assumed, and repeat embolization was performed. After the second embolization, the patient experienced perineal skin necrosis from normal vessel embolization; it was treated with wound dressing changes and healed uneventfully. A third embolization was performed because of a persistent lesion. Six years after treatment, the patient was symptom free, and imaging showed complete ossification of the cyst.
Selective catheterization and occlusion of the feeding arteries with the appropriate embolic agent provide tumor devascularization, size reduction, pain relief, and induction of new bone formation. Multiple procedures are often necessary, and complications may occur.
TKA After Clamshell Osteotomy for Femoral Diaphyseal Malunion
Authors: Wilson Addison J. , Nandi Sumon , Robbins Claire E. , Bono James V. 
Published: June 2012

Proper component positioning is essential for successful total knee arthroplasty (TKA). Femoral component positioning presents a technical challenge when significant femoral deformity is present. Most commonly, an intramedullary guide is used to make an accurate distal femoral cut. However, in the presence of a significant femoral deformity, this is not a viable option.
The use of clamshell osteotomy to restore anatomic alignment in patients with complex femoral diaphyseal deformity is described in the literature. This article describes a case of a patient who underwent staged TKA after clamshell osteotomy and retrograde femoral nailing to correct femoral diaphyseal malunion. The retrograde intramedullary nail was retained and used as an intramedullary guide, allowing for TKA in a routine manner. Using an intramedullary nail as an alignment guide may be more accurate than using extramedullary alignment and may avoid the increased surgical time and potential pin-site stress risers of navigation. It is a simple, effective way to treat complicated diaphyseal femoral deformities in the face of posttraumatic knee arthritis. Further study of this technique with longer follow-up and multiple surgeons is necessary to validate this treatment algorithm.
Outcomes and Complications of Hydrogel Scleral Explant Removal
Authors: Chen Ching J. , Kosek Kevin , Benvenutti Erica 
Published: June 2012

BACKGROUND AND OBJECTIVE:
To report symptoms of extrusion of hydrogel explants after retinal detachment (RD) repair and the outcomes and complications following removal.

PATIENTS AND METHODS:
All 23 patients had previous RD repair by episcleral buckle with hydrogel explant. Signs and symptoms of scleral buckle (SB) extrusion were analyzed. Main outcomes measured were redetachment of the retina, persistent diplopia, and decreased postoperative visual acuity (VA).

RESULTS:
Mean time between RD repair and removal of extruded SB was 16.2 years (range: 11 to 21 years). Fifteen patients (65%) received encircling SB and 8 had segmental SB. SB was combined with vitrectomy in 12 patients and 3 received silicone oil. Common complaints included limited ocular motility, presence of a palpable mass under the eyelid, pain and discomfort, diplopia, visible SB under eroded conjunctiva, complete immobility, and signs of infection. Two eyes were phthisical. No scleral perforations occurred during removal of explants. After SB removal, RD recurred in 2 patients and diplopia persisted in 4. VA was not affected by SB removal.

CONCLUSION:
Deterioration may occur after implantation for 10 years or longer. This is due to microstructural change of the hydrogel material. The most common problems are motility disturbance and presence of a tumor-like, palpable mass under the eyelid. Removal of the implant can alleviate some ocular problems. However, RD can recur and diplopia may persist after removal of the SB. Vision usually is not affected.
American Telemedicine Association 2012 Fall Forum
Authors: Forstag Benjamin 
Published: June 2012

The ATA 2012 Fall Forum will follow a similar format to our highly-rated 2011 program, which was filled with unique ideas in an innovative format. We are looking for short talks, two-person dialogues, and demonstrations or other inventive presentation formats on a wide range of telemedicine subject areas. Topics might include: a unique approach to delivering telehealth services; a new and better device; a successful way of introducing telemedicine to providers or consumers; a novel way to organize and fund a program; or a fresh look at overcoming a barrier.
Tele-Dysphagia Management: An Opportunity for Prevention, Cost-Savings and Advanced Training
Authors: Coyle James 
Published: June 2012

Many patients survive severe stroke because of aggressive management in intensive care units. However, acquiring pneumonia during the post-onset phase significantly reduces both the quality and likelihood of survival. Aspiration pneumonia (AP), a relatively recent addition to the list of the pneumonias, is associated with dysphagia, a swallowing disorder that may cause aspiration of swallowed food or liquids mixed with bacterial pathogens common to saliva, or by aspiration of gastric contents due to emesis or gastroesophageal reflux. While it is within the purview of speech-language pathologists to provide evaluation, treatment, and management of dysphagia, the number of patients with dysphagia is growing faster than the number of qualified dysphagia clinicians. Because dysphagia consultations via telepractice are feasible and relatively accessible from a technological standpoint, they offer a promising strategy to bring the expertise of distant dysphagia experts to patients in underserved areas. Tele-dysphagia management has the potential to increase patients’ survival, enhance the expertise of primary, local clinicians, and reduce healthcare costs. Even a modest reduction in either hospital admissions for aspiration pneumonia, or in the length of stay for AP, could save the US health care system hundreds of millions of dollars each year. Wide spread tele-dysphagia management offers significant opportunities for prevention, cost-savings and advanced training, and is therefore worthy of consideration by stakeholders in the health care system and university training programs.
Speech Therapy Telepractice for Vocal Cord Dysfunction (VCD): MaineCare (Medicaid) Cost Savings
Authors: Towey Michael P. 
Published: June 2012

This Brief Communication represents an analysis of the cost savings to MaineCare (also referred to as Medicaid) directly attributable to service provided via speech therapy telepractice. Seven female (primarily adolescent) MaineCare patients consecutively referred to Waldo County General Hospital (WCGH) with suspected diagnosis of Vocal Cord Dysfunction (VCD) were treated by speech therapy telepractice. Outcome data demonstrated a first month cost savings of $2376.72. The analysis additionally projected thousands of dollars of potential savings each month in reduced medical costs for this patient group as a result of successful treatment via speech therapy telepractice. The study suggests that without access to speech therapy telepractice for patients with VCD, the ongoing medical costs to MaineCare will be ongoing and significant.
Perivascular Stem Cells: A Prospectively Purified Mesenchymal Stem Cell Population for Bone Tissue Engineering
Authors: James Aaron W. , Zara Janette N. , Zhang Xinli , Askarinam Asal , Goyal Raghav , Chiang Michael , Yuan Wei , Chang Le , Corselli Mirko , Shen Jia , Pang Shen , Stoker David , Wu Ben , Ting Kang , Péault Bruno , Soo Chia 
Published: June 2012

Abstract
Adipose tissue is an ideal source of mesenchymal stem cells for bone tissue engineering: it is largely dispensable and readily accessible with minimal morbidity. However, the stromal vascular fraction (SVF) of adipose tissue is a heterogeneous cell population, which leads to unreliable bone formation. In the present study, we prospectively purified human perivascular stem cells (PSCs) from adipose tissue and compared their bone-forming capacity with that of traditionally derived SVF. PSCs are a population (sorted by fluorescence-activated cell sorting) of pericytes (CD146+CD34−CD45−) and adventitial cells (CD146−CD34+CD45−), each of which we have previously reported to have properties of mesenchymal stem cells. Here, we found that PSCs underwent osteogenic differentiation in vitro and formed bone after intramuscular implantation without the need for predifferentiation. We next sought to optimize PSCs for in vivo bone formation, adopting a demineralized bone matrix for osteoinduction and tricalcium phosphate particle formulation for protein release. Patient-matched, purified PSCs formed significantly more bone in comparison with traditionally derived SVF by all parameters. Recombinant bone morphogenetic protein 2 increased in vivo bone formation but with a massive adipogenic response. In contrast, recombinant Nel-like molecule 1 (NELL-1; a novel osteoinductive growth factor) selectively enhanced bone formation. These studies suggest that adipose-derived human PSCs are a new cell source for future efforts in skeletal regenerative medicine. Moreover, PSCs are a stem cell-based therapeutic that is readily approvable by the U.S. Food and Drug Administration, with potentially increased safety, purity, identity, potency, and efficacy. Finally, NELL-1 is a candidate growth factor able to induce human PSC osteogenesis.
Targeting Efficiency and Biodistribution of Zoledronate Conjugated Docetaxel Loaded Pegylated PBCA Nanoparticles for Bone Metastasis
Authors: Chaudhari Kiran R. , Kumar Abhinesh , Khandelwal Vinoth Kumar Megraj , Mishra Anil K. , Monkkonen Jukka , Murthy Rayasa S. Ramachandra 
Published: June 2012

AbstractIn an attempt to improve tumor localization of docetaxel (DTX)‐loaded nanoparticles (NPs), zoledronic acid (ZOL) is used as a ligand to target bone metastasis. DTX‐loaded ZOL‐conjugated polyethylene glycol (PEG)ylated polybutyl cyanoacrylate (PBCA) NPs are prepared using an anionic polymerization technique. PBCA‐PEG‐ZOL NPs are subjected to cytotoxic assay in both BO2 and MCF‐7 cell lines. Cell cycle arrest and apoptosis induced by the PBCA‐PEG‐ZOL NPs are studied. Quantitative cellular uptake, NP uptake route characterization, confocal microscopy and IPP/ApppI levels are performed. PBCA‐PEG‐ZOL NPs show an enhanced cytotoxic effect in both BO2 as well as MCF‐7 cell lines due to higher uptake following ZOL‐mediated endocytosis. The molecular basis of apoptosis reveals the involvement of a cytoplasmic protein in activating the programmed cell death pathway. Route characterization studies reveal that PBCA‐PEG‐ZOL NPs uptake is not completely blocked even by using both inhibitors (genistein and phenyl arsinoxide) simultaneously, conferring that uptake is not entirely based upon clathrin or caveolae. PBCA‐PEG‐ZOL NPs showed 7 and 5.3 times increase in IPP and ApppI production, in comparison to ZOL treatment, and 138 times higher than the control group in MCF‐7 cell line. In BO2 cell line, after treatment with NPs, IPP was 5.35 times higher than ZOL solution. No ApppI in BO2 cell line after treatment with NPs and ZOL solution was found. NP distribution in tumor infected bone is also significantly high in comparison to the normal bone at any time point. It is concluded that ZOL‐conjugated NPs provide an efficient and targeted delivery of DTX, with synergistic effects. Thus, these NPs present a promising treatment in the near future, by actively targeting metastatic tumor.