bluuebunny/crossref_metadata_2025_split huggingface dataset:
Getting a grip on how we talk about computational practices in science in settings of teacher learning
Authors: Farris Amy Voss , McLaughlin Gözde 
Published: May 2024

AbstractBackgroundScience teachers' understanding of the roles of computing practices in science frame how they enact scientific computational practices in their teaching and how their students perceive the relationship between computational practices and scientific endeavours.ObjectivesThis critical, integrative review synthesizes teacher learning literature about the role of computational literacy and computing practices in K‐12 science teaching.MethodsWe examined 54 peer‐reviewed articles and analysed the ways the researchers and teacher participants describe the affordances of integrating computational thinking (CT) and other computational practices in science. We characterize how CT and computational practices are framed in relation to scientific learning goals. We identify six primary affordances for integrating computational practices with science that are conveyed to teachers and by teachers, as represented in these studies of teacher learning.Results and ConclusionsThese six perspectives include (1) learning computer science principles, (2) developing CT dispositions, (3) engagement and inclusion in science, (4) taking ownership of science, (5) supporting learning science content, and (6) participating in computational practice as a form of scientific epistemic practice. Our analysis indicates that computational thinking and computational practices are often integrated in science in order to teach something about computing (e.g., Perspective 1), rather than to support learners' scientific work. Only the 29 articles coded for the sixth perspective—that is, in service of epistemic aims in science—demonstrate commitment to students' uses of computational ideas and practices as epistemic tools to participate in the sensemaking work of science.TakeawaysComparison of Perspectives 5 and 6 illustrates the nuance between computational practices in science that reify something students have already “figured out,” rather than those that serve epistemic goals. Perspective 6 encapsulates the deep synergy among (1) the reflexive nature of computing with scientific ideas and (2) computing as a central practice in science and engineering. We contend that a more focused message of computational practices in service of scientific sensemaking goals is necessary if we expect teachers to enact CT and related computational practices in their classrooms.
Cumulative sedimentation hazard map of urban areas subject to hyperconcentrated flash flood: A case study of Suide County in the Wuding River basin, China
Authors: Lai Ruixun , Li Junhua , Wang Ping , Guo Yan , Xu Linjuan , Zhang Xiangping , Wang Min , Zhang Xiaoli 
Published: May 2024

AbstractFlash floods can carry substantial sediment, posing significant sedimentation hazards in hilly cities. The sedimentation hazard map can reproduce the sediment thickness and extent of an extreme events scenario, playing an important role in sediment risk management. However, current research primarily focuses on modeling the inundation area and depth of floods, while studying sedimentation hazard caused by flash floods in urban areas remains insufficient. This paper aims to address this gap by utilizing a numerical model that simulates hyperconcentrated flow in hilly urban areas using the two‐dimensional hydro‐sediment‐morphological model to compile the cumulative sedimentation hazard map. The model, built upon the open‐source TELEMAC‐MASCARET framework, incorporates Zhang Hongwu's formula to simulate sediment‐carrying capacity, particularly suitable for hyper‐sediment concentration near the riverbed. This paper uses the data of extreme flash flood events in the Wuding River basin in 2017 to simulate and compile the cumulative sedimentation hazard map. The hazard map delineates the sedimentation hazard extent and level attributable to overbank floodplain sedimentation. Notably, the sediment thickness is highest in areas near the levees on both sides of the Dali River. Moreover, the map illustrates the extent of channel erosion resulting from hyperconcentrated floods, which could jeopardize bank stability.
Long‐term flood exposure assessment using satellite‐based land use change detection and inundation simulation: A 30‐year case study of the Bangkok Metropolitan Region
Authors: Darnkachatarn Siriporn , Kajitani Yoshio 
Published: May 2024

AbstractThe Bangkok Metropolitan Region (BMR), located in the Chao Phraya River basin delta, is particularly vulnerable to floods, with susceptibility heightened by geographical aspects and rapid urbanization. This study aimed to assess spatiotemporal flood exposure and allow proper flood‐risk recognition among all stakeholders through a three‐phase flood exposure assessment. First, land use and land cover (LULC) changes were identified based on a 30‐year Landsat time series. Second, built‐up areas that overlapped with past flood inundation maps were designated as flood exposure areas. Third, a rainfall‐runoff inundation (RRI) model simulated the 2011 Thailand Flood, the largest on record, by analyzing inundation depth implications across three decades. The findings revealed a dramatic increase in the use of built‐up areas and the associated flood exposure. In 1992, built‐up areas accounted for approximately 20% of the total area, sharply increasing to nearly 45% by 2022, according to the LULC classification. The flood exposure increased from 648.83 km2 in 1992 to 1681.26 km2 by 2022, demonstrating a linear trend. Notably, the catastrophic 2011 flood did not inhibit urbanization in flood‐prone areas, highlighting the need for robust policies, such as the segmentation of flood‐risk zones, to mitigate future exposure in the region.
Positive impact of obesity on the prognosis of liver cirrhosis
Authors: Endo Kei , Kakisaka Keisuke , Abe Tamami , Yusa Kenji , Nakaya Ippeki , Watanabe Takuya , Suzuki Akiko , Yoshida Yuichi , Oikawa Takayoshi , Miyasaka Akio , Kuroda Hidekatsu , Matsumoto Takayuki 
Published: May 2024

AbstractBackground and AimThe study aims to determine the prognostic impact of obesity, sarcopenic obesity, and dynapenic obesity in patients with chronic liver disease.MethodsThis retrospective observational study enrolled patients with chronic hepatitis (n = 746) and liver cirrhosis (n = 434) without hepatocellular carcinoma at entry. The patients were evaluated for sarcopenia and obesity between April 2016 and April 2022. Obesity was defined as a body mass index of ≥ 25 kg/m2. Sarcopenic obesity was defined as low skeletal muscle mass (pre‐sarcopenia) with obesity and dynapenic obesity was defined as low muscle strength (dynapenia) with obesity. The effects of obesity on survival were evaluated retrospectively.ResultsThe mean observation period was 2.5 years. Obesity, sarcopenic obesity, and dynapenic obesity were found in 271 (45.5%), 17 (2.9%), and 21 (3.5%) men, and 261 (44.7%), 59 (10.1%), and 53 (9.1%) women, respectively. A multivariate Cox proportional hazards model revealed that Child–Pugh class, dynapenia (hazard ratio [HR] 3.89), elderly (≥ 65 years old) (HR 2.11), and obesity (HR 0.58) were independently associated with overall survival (OS). However, neither sarcopenic nor dynapenic obesity were associated with OS. In patients with cirrhosis, the OS of the obese group was significantly higher than that of the non‐obese group. The effect of obesity on OS was significant in elderly patients, but not in younger patients.ConclusionsSarcopenic and dynapenic obesity seem unrelated to the prognosis of patients with chronic liver disease. Obesity has a positive effect on the prognosis of elderly patients with cirrhosis.
Healthcare use and out‐of‐pocket costs for rural family caregivers and care recipients in a randomized controlled trial
Authors: Kaufman Brystana G. , Huang Ro W. , Holland Diane E. , Vanderboom Catherine E. , Ingram Cory , Wild Ellen M. , Dose Ann Marie , Stiles Carole , Gustavson Allison M. , Mandrekar Jay , Van Houtven Courtney H. , Griffin Joan M. 
Published: May 2024

AbstractBackgroundRural family caregivers (FCGs) in the United States often experience high economic costs. This randomized controlled trial compared a transitional palliative care intervention (TPC) to support FCGs of seriously ill care recipients (CRs) to an attention control condition. We evaluated the TPC's effect on healthcare use and out‐of‐pocket spending for both FCGs and CRs.MethodsTPC FCGs received teaching, guidance, and counseling via video calls for 8 weeks following CR discharge from the hospital. After discharge, a research assistant called all FCGs once a month for up to 6 months or CR death to collect self‐reported healthcare utilization (e.g., outpatient, emergency department, and hospital), out‐of‐pocket healthcare spending (e.g., deductibles and coinsurance), and health‐related travel costs (e.g., transportation, lodging, food) for FCGs and CRs. Incidence rate ratios (IRRs) were estimated using negative binomial regressions.ResultsThe study included 282 FCG–CR dyads across three U.S. states. Follow‐up over the 6‐month period was shortened by high CR mortality rates across both arms (29%), but was similar across arms. TPC reduced nights in the hospital for CR (IRR = 0.75; 95% confidence interval [CI] = 0.56–0. 99). Total out‐of‐pocket spending was not significantly different for TPC versus control. Across both groups, mean out‐of‐pocket spending for dyads was $1401.85, with healthcare payments contributing $1048.58 and transportation expenses contributing $136.79. TPC dyads reported lower lodging costs (IRR = 0.71; 95% CI = 0.56–0.89).ConclusionsThis study contributes to evidence that palliative care interventions reduce the number of nights in the hospital for seriously ill patients. Yet, overall rural FCGs and seriously ill CRs experience substantial out‐of‐pocket economic costs in the 6 months following hospitalization. Transitional care intervention design should consider impacts on patient and caregiver spending. Clinicaltrials.gov # is NCT03339271.
High‐throughput molecular assays for inclusion in personalised oncology trials – State‐of‐the‐art and beyond
Authors: Edsjö Anders , Russnes Hege G. , Lehtiö Janne , Tamborero David , Hovig Eivind , Stenzinger Albrecht , Rosenquist Richard ,   the PCM4EU consortium
Published: May 2024

AbstractIn the last decades, the development of high‐throughput molecular assays has revolutionised cancer diagnostics, paving the way for the concept of personalised cancer medicine. This progress has been driven by the introduction of such technologies through biomarker‐driven oncology trials. In this review, strengths and limitations of various state‐of‐the‐art sequencing technologies, including gene panel sequencing (DNA and RNA), whole‐exome/whole‐genome sequencing and whole‐transcriptome sequencing, are explored, focusing on their ability to identify clinically relevant biomarkers with diagnostic, prognostic and/or predictive impact. This includes the need to assess complex biomarkers, for example microsatellite instability, tumour mutation burden and homologous recombination deficiency, to identify patients suitable for specific therapies, including immunotherapy. Furthermore, the crucial role of biomarker analysis and multidisciplinary molecular tumour boards in selecting patients for trial inclusion is discussed in relation to various trial concepts, including drug repurposing. Recognising that today's exploratory techniques will evolve into tomorrow's routine diagnostics and clinical study inclusion assays, the importance of emerging technologies for multimodal diagnostics, such as proteomics and in vivo drug sensitivity testing, is also discussed. In addition, key regulatory aspects and the importance of patient engagement in all phases of a clinical trial are described. Finally, we propose a set of recommendations for consideration when planning a new precision cancer medicine trial.
Development and validation of a standard area diagram set to assess corn grey leaf spot severity and foliar fungicide control efficacy
Authors: Rocha Maria Gabriela de Carlos da , Custódio Adriano Augusto de Paiva , Fantin Lucas Henrique , de Oliveira Karla Braga , Campos Hércules Diniz , Canteri Marcelo Giovanetti , Duarte Henrique da Silva Silveira 
Published: May 2024

AbstractGrey leaf spot (GLS), caused by Cercospora spp., has become a very important foliar disease for second‐crop corn season, mainly in South America. Therefore, this study aimed to develop and validate a standard area diagram set (SADs) to estimate the severity of GLS and to apply the SADs established in this study to evaluate the efficacy of fungicides for GLS control in field trials. The SADs with nine levels of severity (0.5; 2; 5; 10; 20; 30; 40; 50 and 60%) improved accuracy, precision and reliability. To evaluate the control of GLS in corn, two experiments spraying chemical fungicides were conducted, one in Rio Verde (GO) (experiment A) and another in Chapadão do Sul (MS) (experiment B). Both experiments were conducted in randomized block design, with 10 treatments and four replicates. For the severity assessment, the SADs elaborated in this study was used. From this severity data over time, disease progress curves, area under the disease progress curve (AUDPC), and yield were obtained. Based on the AUDPC and yield values, all treatments differed from the control. The fungicide fluxapyroxad + pyraclostrobin + mefentrifluconazole had the highest value, giving 72.8% control efficacy and the highest yield maintenance of 43.5%. The other treatments had an intermediate control efficacy and yield. The SADs proposed here is a useful tool for improving visual assessments of GLS severity on corn leaves and fungicides can be used for integrated disease management.
Growth, survival, digestive activity and respiratory metabolism of Octopus maya juveniles fed with prepared diets
Authors: Santiago Israel , Rosas Carlos , Cruz‐López Honorio , Domingues Pedro , Pascual Cristina , Mascaro Maite , Sanchez‐Arteaga Ariadna , Caamal Claudia , Gallardo Pedro 
Published: May 2024

AbstractThe effects of two prepared feeds were tested on growth, survival, enzymatic activity, nutritive reserves in the digestive gland and oxygen consumption of Octopus maya juveniles. For the first time, a semihumid paste (HD, control) and a dry diet, in pelleted form (PD, experimental) with the same formulation were used for this species. The experiment lasted for 42 days. Results indicate that growth rates were similar for both diets (p > 0.05); however, survival (70%) was higher with the PD compared to the HD (48%) (p < 0.05). The performance index was higher for octopuses fed the PD (p < 0.05). No differences in acid proteases activity were observed. However, a higher activity of alkaline proteases in the octopuses fed the PD was observed (p < 0.05). Ingestion rate was higher for octopuses fed the PD. Routine energy inversion was similar in both treatments (p > 0.05). A greater energy inversion was observed in octopuses fed the PD, whose active metabolism was double compared to the octopuses fed the HD. Results showed that the PD promoted similar growth compared to the HD diet but favored survival, and a greater investment in the active metabolism, reflected in the apparent heat increase.
Vaspin facilitates the proliferation and osteogenic differentiation of periodontal ligament stem cells
Authors: Jing Zhihui , Feng Xinran , Li Xin , Zhang Xiaoyu , Pan Chunling 
Published: May 2024

AbstractObjectiveTo investigate whether visceral adipose tissue‐derived serine protease inhibitor (vaspin) can alleviate the inhibitory effect of high‐glucose (HG) culture on the proliferation and osteogenic differentiation of human periodontal ligament stem cells (PDLSCs) and to preliminarily explore the underlying mechanisms.BackgroundHigh glucose produces damage to the regeneration of periodontal tissue of PDLSCs. The expression level of vaspin in periodontal tissue is high in periodontitis patients and effectively reduced after initial therapy of periodontal diseases. However, the effect of vaspin on PDLSCs remains unknown.Materials and MethodsPDLSCs were cultured in media augmented with 5.5 or 25.0 mM concentrations of glucose to elucidate the impact and mechanism of vaspin on PDLSCs under high glucose in vitro. Proliferation was measured by Cell Counting Kit‐8 (CCK8) assay. Osteogenesis of PDLSCs was assessed by alkaline phosphatase (ALP) staining, ALP activity, and Alizarin Red staining. Quantitative real‐time polymerase chain reaction (qRT‐PCR) and western blot (WB) were used to investigate the osteo‐specific markers. Then, the molecular impact of vaspin in the presence/absence of HG on PDLSCs physiology was determined with TGF‐β1/Smad signaling pathway as the main focus.ResultsIt was revealed that the proliferation and osteogenic differentiation (OD) of PDLSCs under HG was reduced, and by adding vaspin the anti‐osteogenic impact of HG was relieved. Moreover, vaspin enhanced TGF‐β1/Smad signaling pathway activity. Pretreatment with TGF‐β1 inhibitor blocked vaspin‐triggered TGF‐β1/Smad signal activation and minimized the vaspin‐induced protective effect against HG‐inhibited growth and OD.ConclusionsIn summary, vaspin observably reduces HG‐mediated inhibition of PDLSCs OD by modulating the TGF‐β1/Smad signaling pathway. Vaspin may be a potential therapeutic for periodontal tissue regeneration in diabetic patients.
Client's understanding of instructions for small animals in a veterinary neurological referral center
Authors: Flegel Thomas , Dobersek Katharina , Bayer Sabrina , Becker Lisa F. , Loderstedt Shenja , Böttcher Irene C. , Dietzel Josephine , Tästensen Carina , Kalliwoda Theresa , Harkenthal Marie A. , Kühnapfel Andreas , Weiß Vivian , Gutmann Sarah 
Published: May 2024

AbstractBackgroundIt is not known how much information clients retrieve from discharge instructions.ObjectiveTo investigate client's understanding of discharge instructions and influencing factors.AnimalsDogs and cats being hospitalized for neurological diseases.MethodsClients were presented questionnaires regarding their pet's disease, diagnostics, treatments, prognosis and discharge instructions at time of discharge and 2 weeks later. The same questions were answered by discharging veterinarians at time of discharge. Clients answered additional questions regarding the subjective feelings during discharge conversation. Data collected included: data describing discharging veterinarian (age, gender, years of clinical experience, specialist status), data describing the client (age, gender, educational status). Raw percentage of agreement (RPA) between answers of clinicians and clients as well as factors potentially influencing the RPA were evaluated.ResultsOf 230 clients being approached 151 (65.7%) and 70 (30.4%) clients responded to the first and second questionnaire, respectively (130 dog and 30 cat owners). The general RPA between clinician's and client's responses over all questions together was 68.9% and 66.8% at the 2 time points. Questions regarding adverse effects of medication (29.0%), residual clinical signs (35.8%), and confinement instructions (36.8%) had the lowest RPAs at the first time point. The age of clients (P = .008) negatively influenced RPAs, with clients older than 50 years having lower RPA.Conclusions and Clinical ImportanceClients can only partially reproduce information provided at discharge. Only clients' increasing age influenced recall of information. Instructions deemed to be important should be specifically stressed during discharge.
Corticosteroid monotherapy versus combined cytarabine continuous rate infusion and corticosteroid therapy in dogs with meningoencephalitis of unknown origin: A blinded, randomized, controlled trial
Authors: Jones Bethan S. , Liebel Francois Xavier , Fadda Angela , Martin Sophie , Lawn Richard , Lazzerini Kali , Harcourt‐Brown Thomas 
Published: May 2024

AbstractBackgroundTreatment options available for meningoencephalitis of unknown origin (MUO) in dogs are suboptimal, and currently, no single treatment protocol appears to be superior.ObjectivesCompare neurological deterioration rates at 7 days between dogs with MUO treated with corticosteroids alone or combined with cytosine arabinoside (CA) continuous rate infusion (CRI) and compare clinical deterioration and survival at 30 and 100 days.AnimalsSixty‐nine dogs with magnetic resonance imaging (MRI) and cerebrospinal fluid (CSF) features or both compatible with MUO.MethodsParallel, blinded, randomized controlled trial. Simple randomization into 2 treatment groups: 4 mg/kg/day prednisolone (or dexamethasone equivalent) for 2 days or 200 mg/m2 CA CRI over 8 hours plus 2 mg/kg/day prednisolone. Blinding of the treatment protocol was carried out using reversible redaction of clinical records, and treatment failure was defined as deterioration of neurological assessment or death. Using intention‐to‐treat analysis, proportions failing treatment at 7, 30, and 100 days were compared using Fisher's exact test. All‐cause mortality at 100 days was compared using Kaplan‐Meier survival curves.ResultsThirty‐five dogs were allocated to corticosteroid only, and 34 dogs were allocated to combined CA CRI and corticosteroid. Proportions failing treatment at 7, 30, and 100 days were 7/35 (20%), 9/35 (26%), and 15/35 (43%) in the corticosteroid‐only group and 8/34 (24%), 11/34 (32%), and 23/34 (68%) in the corticosteroid and CA CRI group. All‐cause mortality at 100 days was not significantly different between groups (P = .62). Clinically relevant treatment‐related adverse effects were not observed.Conclusions and Clinical ImportanceWe found no difference in outcome between corticosteroid monotherapy and combined cytarabine CRI and corticosteroid therapy at 7, 30, and 100 days after diagnosis in dogs with MUO.
Outcomes and management in paediatric autoimmune hepatitis presenting as acute liver failure: Individual patient data meta‐analysis
Authors: Fawzy Aly , Sutton Harry , Vandriel Shannon M. , Sonnenberg Mikayla , Kamath Binita M. 
Published: May 2024

AbstractBackground and AimsAutoimmune hepatitis (AIH) in children presenting in acute liver failure (ALF) can be fatal and often requires liver transplantation (LTx). This individual patient data meta‐analysis (IPD) aims to examine management and outcomes of this population, given the lack of large cohort studies on paediatric AIH first presenting as ALF (AIH‐ALF).MethodsA systematic review was conducted in accordance with the Preferred Reporting Items for Systematic Review and Meta‐Analyses of IPD statement using PubMed and Excerpta Medica dataBASE, and included English studies published between 2000 and 2020. The study included patients under 21 years of age, diagnosed with type 1 or 2 AIH and presenting with ALF. Data extracted included clinical and biochemical characteristics, interventions, and outcomes.ResultsThree hundred and thirty eligible patients from 61 studies were identified, with an additional five patients from our institution. The majority were female (66.8%), with a median age of 10. Overall, 59.7% achieved native liver survival (NLS), 35% underwent LTx, and 5% died before LTx. The use of corticosteroids with non‐steroid immunomodulators increased the likelihood of NLS by 2.5‐fold compared to corticosteroids alone. AIH‐1 was associated with 3.3‐fold odds for NLS, compared to AIH‐2. However, on multivariate analysis, only AIH‐1 was identified as an independent predictor for NLS (OR 3.8 [95% CI 1.03–14.2], p = .04).ConclusionWhile corticosteroids and non‐steroid immunomodulators treatment may offer enhanced probability of achieving NLS, treatment regimens for AIH‐ALF may need to consider patient‐specific factors, especially AIH type. This highlights the potential for NLS in AIH‐ALF and suggest a need to identify biomarkers which predict the need for combination immunosuppression to avoid LTx.