bluuebunny/crossref_metadata_2025_split huggingface dataset:
Relationship Between Vein Graft Failure and Subsequent Clinical Outcomes After Coronary Artery Bypass Surgery
Authors: Lopes Renato D. , Mehta Rajendra H. , Hafley Gail E. , Williams Judson B. , Mack Michael J. , Peterson Eric D. , Allen Keith B. , Harrington Robert A. , Gibson C. Michael , Califf Robert M. , Kouchoukos Nicholas T. , Ferguson T. Bruce , Alexander John H. 
Published: January 2012

Background—
Vein graft failure (VGF) is common after coronary artery bypass graft surgery, but its relationship with long-term clinical outcomes is unknown. In this retrospective analysis, we examined the relationship between VGF, assessed by coronary angiography 12 to 18 months after coronary artery bypass graft surgery, and subsequent clinical outcomes.

Methods and Results—

Using the Project of Ex Vivo Vein Graft Engineering via Transfection IV (PREVENT IV) trial database, we studied data from 1829 patients who underwent coronary artery bypass graft surgery and had an angiogram performed up to 18 months after surgery. The main outcome measure was death, myocardial infarction, and repeat revascularization through 4 years after angiography. VGF occurred in 787 of 1829 patients (43%). Clinical follow-up was completed in 97% of patients with angiographic follow-up. The composite of death, myocardial infarction, or revascularization occurred more frequently among patients who had any VGF compared with those who had none (adjusted hazard ratio, 1.58; 95% confidence interval, 1.21–2.06;
P
=0.008). This was due mainly to more frequent revascularization with no differences in death (adjusted hazard ratio, 1.04; 95% confidence interval, 0.71–1.52;
P
=0.85) or death or myocardial infarction (adjusted hazard ratio, 1.08; 95% confidence interval, 0.77–1.53;
P
=0.65).

Conclusions—
VGF is common after coronary artery bypass graft surgery and is associated with repeat revascularization but not with death and/or myocardial infarction. Further investigations are needed to evaluate therapies and strategies for decreasing VGF to improve outcomes in patients undergoing coronary artery bypass graft surgery.
Characterizing and Identifying Risk for Falls in the LEAPS Study
Authors: Tilson Julie K. , Wu Samuel S. , Cen Steven Y. , Feng Qiushi , Rose Dorian R. , Behrman Andrea L. , Azen Stanley P. , Duncan Pamela W. 
Published: January 2012

Background and Purpose—
Better understanding of fall risk poststroke is required for developing screening and prevention programs. This study characterizes falls in the Locomotor Experience Applied Post-Stroke (LEAPS) randomized clinical trial, describes the impact of 2 walking recovery interventions on falls, and examines the value of clinical assessments for predicting falls.

Methods—
Community-dwelling ambulatory stroke survivors enrolled in LEAPS were assessed 2 months poststroke. Falls were monitored until 12 months poststroke and participants were characterized as multiple or injurious (M/I); single, noninjurious; or nonfallers. Incidence and time to M/I falls were compared across interventions (home exercise and locomotor training initiated 2 months [early-LTP] or 6 months [late-LTP] poststroke). Predictive value of 2-month clinical assessments for falls outcome was assessed.

Results—

Among the 408 participants, 36.0% were M/I, 21.6% were single, noninjurious, and 42.4% were nonfallers. Most falls occurred at home in the first 3 months after assessment. Falls incidence was highest for those with severe walking impairment who received early-LTP (
P
=0.025). Berg Balance Scale score ≤42/56 was the single best predictor of M/I falls.

Conclusions—
As individuals with stroke improve in walking capacity, risk for M/I falls remains high. Individuals walking <0.4 m/s are at higher risk for M/I falls if they receive early-LTP training. Berg Balance Scale score at 2 months poststroke is useful for informing falls risk, but it cannot account for the multifactorial nature of the problem. Falls prevention in stroke will require multifactorial risk assessment and management provided concomitantly with exercise interventions to improve mobility.

Clinical Trial Registration—

URL:
http://www.clinicaltrials.gov
. Unique identifier: NCT00243919.
Custom and Society in Islamic Criminal Law: A Critical Appraisal of the Maxim ‘al-ʿĀdah Muḥakkamah’ (Custom is Authoritative) and its Sisters in Islamic Legal Procedures
Authors: Zakariyah Luqman 
Published: January 2012

Abstract
Islamic legal maxims promote the spirit of Islamic law through extrapolation of the texts. The legal maxim of al-ʿādah is one of the five basic legal maxims agreed upon among classical Muslim jurists. Despite the wide acceptability of custom in Islamic legal theory and its authoritativeness in application, one of the controversial issues surrounding the use of custom (al-ʿādah) is whether, by law, rulings can be changed over time when customs have changed. Thus, this article aims to examine the effect of custom in rulings related to ḥudūd and qiṣāṣ (fixed and retaliative punishments) in Islamic law and whether such rulings can be changed over time as custom changes and, if they can be changed, to what extent can such changes be made and to what effect do such changes affect the sanctity of the Qurʾān and Ḥadīth texts.
Diagnosing Kenya Rainfall in Boreal Autumn: Further Exploration
Authors: Mutai Charles , Polzin Dierk , Hastenrath Stefan 
Published: January 2012

Abstract
A powerful zonal vertical circulation cell along the Indian Ocean equator controls the boreal autumn rains in Kenya, with a tight negative correlation between surface westerlies (UEQ) and rainfall. UEQ is favored by a steep eastward pressure gradient (PWE) and slow winds in the downstream portion of the South Indian Ocean trade winds (SIW). The high phase of the Southern Oscillation (SO) favors weak SIW, lower pressure in the east, and thus steeper PWE, but that is also affected by pressure in the west. In 1958–97 circulation causalities were most distinct in the regime of abundant rain and slow UEQ, with the SO in the low phase. In the regime of deficient rain and fast UEQ, relationships were less distinct, although the SO was in the high phase almost throughout. In the decade 2001–10, UEQ had a weaker (stronger) correlation with PWE (SIW), the SO was more active and contributing in the proper sense to pressure in the east, but PWE was mainly controlled by pressure in the west. UEQ strongly controlled the rainfall in 1958–97 and 2001–10.
Exploring Mechanisms of Variability and Predictability of Atlantic Meridional Overturning Circulation in Two Coupled Climate Models
Authors: Tulloch Ross , Marshall John 
Published: January 2012

Abstract
Multidecadal variability in the Atlantic meridional overturning circulation (AMOC) of the ocean is diagnosed in the NCAR Community Climate System Model, version 3 (CCSM3), and the GFDL Coupled Model (CM2.1). Common diagnostic approaches are applied to draw out similarities and differences between the two models. An index of AMOC variability is defined, and the manner in which key variables covary with it is determined. In both models the following is found. (i) AMOC variability is associated with upper-ocean (top 1 km) density anomalies (dominated by temperature) on the western margin of the basin in the region of the Mann eddy with a period of about 20 years. These anomalies modulate the trajectory and strength of the North Atlantic Current. The importance of the western margin is a direct consequence of the thermal wind relation and is independent of the mechanisms that create those density anomalies. (ii) Density anomalies in this key region are part of a larger-scale pattern that propagates around the subpolar gyre and acts as a “pacemaker” of AMOC variability. (iii) The observed variability is consistent with the primary driving mechanism being stochastic wind curl forcing, with Labrador Sea convection playing a secondary role. Also, “toy models” of delayed oscillator form are fitted to power spectra of key variables and are used to infer “quality factors” (Q-factors), which characterize the bandwidth relative to the center frequency and hence AMOC predictability horizons. The two models studied here have Q-factors of around 2, suggesting that prediction is possible out to about two cycles, which is likely larger than the real AMOC.
Baroclinic Interleaving Instability: A Second-Moment Closure Approach
Authors: Smyth W. D. , Burchard H. , Umlauf L. 
Published: January 2012

Abstract
Interleaving motions on a wide, baroclinic front are modeled using a second-moment closure to represent unresolved fluxes by turbulence and salt fingering. A linear perturbation analysis reveals two broad classes of unstable modes. First are scale-selective modes comparable with interleaving as observed in oceanic fronts. These correspond well with observations in some respects but grow by a very different mechanism, which ought to be easily distinguished in hydrographic profiles. The second mode type is the so-called ultraviolet catastrophe, which is expected to lead to steppy profiles even in the absence of interleaving. Both modes are driven by positive feedbacks between interleaving and the underlying small-scale mixing processes. Contrary to expectations, use of the second-moment closure in place of earlier empirical mixing models does not lead to improved agreement with observations.
Associations between awareness of beyondblue and mental health literacy in Australian youth: Results from a national survey
Authors: Yap Marie B , Reavley Nicola J , Jorm Anthony F 
Published: January 2012

Objectives: The aim of this paper is to examine whether Australian young people’s awareness of beyondblue is associated with better recognition of depression and anxiety disorders, and better quality of beliefs about possible interventions and first-aid actions for these problems. Method: In 2011, a telephone interview was conducted with a national sample of 3021 Australians aged between 15 and 25 years. Participants were presented with a vignette portraying depression, depression with suicidal thoughts, social phobia, post-traumatic stress disorder or psychosis in a young person. They were then asked about recognition of the disorder portrayed, their beliefs about the helpfulness or harmfulness of various interventions and first-aid actions, and their awareness of beyondblue. The quality of youths’ beliefs was scored against health professionals’ ratings of the same list of interventions and first-aid actions. Results: Beyondblue awareness was associated with more accurate recognition of the disorder portrayed in all vignettes except social phobia. It was also associated with beliefs about the helpfulness of first-aid actions that were more closely aligned with professional ratings for the depression, psychosis and social phobia vignettes. However, it was associated with beliefs about interventions for the psychosis vignette only. Conclusions: Overall, the associations of beyondblue awareness with better mental health literacy were not specific to depression and anxiety disorders, which are their main focus. Beyondblue awareness is mostly unrelated to treatment beliefs, but seems to have non-specific associations with recognition of disorders and first-aid beliefs.
Prophylactic Perioperative Antibiotic Use in Endoscopic Sinus Surgery
Authors: Saleh Amy M. , Torres Katherine M. , Murad Mohammad H. , Erwin Patricia J. , Driscoll Colin L. W. 
Published: January 2012

ContextPerioperative antibiotics are widely used to improve the outcomes of endoscopic sinus surgery.ObjectiveThe aim of this study was to summarize the evidence on the effect of perioperative antibiotic prophylaxis on outcomes of endoscopic sinus surgery.Data Sources and Review MethodsWe searched electronic databases from inception through May 2011 for any relevant clinical trials or observational studies. Two reviewers working independently extracted study characteristics, quality, and the outcomes of interest. Random‐effects meta‐analysis was used to pool the relative risks (RRs) and the standardized mean differences (SMDs) across trials.ResultsWe found 4 eligible trials with varying quality, of which 3 were included in the quantitative analysis. Antibiotic prophylaxis was associated with a nonsignificant reduction in the incidence of infections (relative risk, 0.76; 95% confidence interval [CI], 0.64 to 1.09), symptoms scores (SMD, −0.04; 95% CI, −0.46 to 0.38), and endoscopic scores (SMD, −0.09; 95% CI, 0.30 to 0.13). The heterogeneity associated with the analysis was significant only for the outcome of change in symptoms score (I‐squared values, 0%, 70%, and 0% for the 3 outcomes, respectively).ConclusionsTrial data available to date are unable to demonstrate a statistically significant reduction in infection, symptom scores, or endoscopic scores to support the routine use of postoperative prophylactic antibiotics following endoscopic sinus surgery. Our analysis was limited by the number of published trials related to this topic.
2012 Update on Meaningful Use of Electronic Health Records
Authors: Sun Gordon H. , Eisenberg Lee D. , Ermini Edward B. , Lee K. J. , Nielsen David R. , Rubin Koryn Y. , Das Subinoy 
Published: January 2012

In 2011, the US federal government implemented an oversight program to encourage the adoption and meaningful use of electronic health records (EHRs). Otolaryngologists may receive as much as $44,000 under Medicare or $63,750 under Medicaid as part of this law. To receive this full benefit, otolaryngologists must acquire a certified EHR and demonstrate stage 1 meaningful use requirements by the end of 2012. Furthermore, the Office of the National Coordinator for Health IT intends to advance meaningful use requirements to stage 2 (estimated to go in effect in 2014) and stage 3 requirements. This commentary discusses updated recommendations from the Academy of Otolaryngology—Head and Neck Surgery Medical Informatics Committee for implementing meaningful use of EHRs, receiving incentive payments, and preparing for potential stage 2 and stage 3 requirements.
Impact of Literacy and Numeracy on Motivation for Behavior Change After Diabetes Genetic Risk Testing
Authors: Vassy Jason L. , O’Brien Kelsey E. , Waxler Jessica L. , Park Elyse R. , Delahanty Linda M. , Florez Jose C. , Meigs James B. , Grant Richard W. 
Published: January 2012

Background Type 2 diabetes genetic risk testing might motivate at-risk patients to adopt diabetes prevention behaviors. However, the influence of literacy and numeracy on patient response to diabetes genetic risk is unknown. Objective The authors investigated the association of health literacy, genetic literacy, and health numeracy with patient responses to diabetes genetic risk. Design and Measurements Overweight patients at high phenotypic risk for type 2 diabetes were recruited for a clinical trial of diabetes genetic risk testing. At baseline, participants predicted how their motivation for lifestyle modification to prevent diabetes might change in response to hypothetical scenarios of receiving “high” and “low” genetic risk results. Responses were analyzed according to participants’ health literacy, genetic literacy, and health numeracy. Results Two-thirds (67%) of participants ( n = 175) reported very high motivation to prevent diabetes. Despite high health literacy (92% at high school level), many participants had limited health numeracy (30%) and genetic literacy (38%). Almost all (98%) reported that high-risk genetic results would increase their motivation for lifestyle modification. In contrast, response to low-risk genetic results varied. Higher levels of health literacy ( P = 0.04), genetic literacy ( P = 0.02), and health numeracy ( P = 0.02) were associated with an anticipated decrease in motivation for lifestyle modification in response to low-risk results. Conclusions While patients reported that high-risk genetic results would motivate them to adopt healthy lifestyle changes, response to low-risk results varied by patient numeracy and literacy. However, anticipated responses may not correlate with true behavior change. If future research justifies the clinical use of genetic testing to motivate behavior change, it may be important to assess how patient characteristics modify that motivational effect.
Observer Agreement on the Dejour Trochlear Dysplasia Classification
Authors: Lippacher Sabine , Dejour David , Elsharkawi Mohammed , Dornacher Daniel , Ring Christina , Dreyhaupt Jens , Reichel Heiko , Nelitz Manfred 
Published: January 2012

Background: Trochlear dysplasia is known to be an important cause of patellofemoral instability. D. Dejour’s radiographic and magnetic resonance imaging (MRI) classifications are widely used in clinical practice and in the orthopaedic literature to assess the severity of trochlear dysplasia. The indication for deepening trochleoplasty to treat trochlear dysplasia is also mainly based on the severity of trochlear dysplasia according to Dejour’s criteria. Purpose: To our knowledge, there is no study evaluating the efficacy of the Dejour classification. The aim of this study was to assess the intraobserver and interobserver agreements of the radiographic and MRI-based classification as described by Dejour. Study Design: Cohort study (diagnosis); Level of evidence, 2. Methods: From 50 patients, 50 lateral radiographs as well as 50 MRI scans were read twice independently within 4 weeks by 4 surgeons (2 senior and 2 junior examiners). Analysis was made according to Dejour’s 4 grades of radiological criteria of trochlear dysplasia as well as differentiating between 2 grades: low-grade (type A) and high-grade trochlear dysplasia (types B-D). Results: The 4-grade analysis showed fair intraobserver and interobserver agreements (24%-78%), while the 2-grade analysis showed good to excellent agreement (56%-96%). The best overall agreement was found for the 2-grade analysis on MRI scans (62%-96%). The lateral radiographs tended to underestimate the severity of trochlear dysplasia compared with axial MRI. Conclusion: D. Dejour’s classification is valid for typing trochlear dysplasia and is particularly useful in separating low-grade from high-grade dysplasia.
Amelioration of cisplatin-induced toxicity in mice by carotenoid meso-zeaxanthin
Authors: Firdous AP , Kuttan R 
Published: January 2012

Carotenoid meso-zeaxanthin ((3R, 3′S)-β, β-carotene-3,3′-diol [MZ]) was evaluated for its protective effect against cisplatin-induced nephrotoxicity in Swiss albino mice. Oral administration of MZ was started 5 days prior to cisplatin (16 mg/kg body weight, intraperitoneally as a single dose) injection. Animals in all groups were killed 72 h after cisplatin treatment. In serum, renal function markers like urea and creatinine, which were drastically elevated in cisplatin-treated control animals, were found to be decreased significantly by MZ pretreatment. Cisplatin-induced myelosuppression was also found to be significantly ameliorated by MZ as evident from the increase in white blood cell count, bone marrow cellularity and number of maturing monocytes in MZ-treated animals when compared with cisplatin alone-treated control animals. The levels of antioxidant enzymes—superoxide dismutase, catalase and glutathione peroxidase—as well as the glutathione level in the kidney were decreased after cisplatin treatment. But the levels were markedly increased by the carotenoid treatment in a dose-dependent manner. Addition of MZ was found to inhibit singlet oxygen produced by toluidine blue in vitro. Moreover, administration of MZ to the animals inhibited increased lipid peroxidation, conjugated dienes and hydroperoxides that are formed in the kidney by cisplatin administration. The results of histopathological analysis supported the protective potential of MZ against cisplatin-induced toxicity.
Regulation and Paediatric Drug Trials: Patents, Plans, and Perverse Incentives
Authors: Gaifulinay Riana 
Published: January 2012

The facilitation of tight regulatory frameworks necessary to ensure that new drugs are safe and effective have yet to be effectively applied within the paediatric population. Utilization of unlicensed and off-label drugs in children results in a variety of problems ranging from inefficacy, adverse reactions and in some cases death. This ethically questionable behaviour has led the European government to legally force pharmaceutical companies to propose paediatric applications and carry out clinical studies at early stages of drug development. The new European Paediatric Regulation implemented in 2007 opens a new era of paediatric drug development and will offer the opportunity to vastly improve children's health. However, this brighter outlook for the paediatric community might encourage potentially unethical behaviour in a pharmaceutical industry that finds itself in economically unstable times. The article records the gradual evolution of the US Paediatric Exclusivity Plan and the underlying principle of the newly introduced European Paediatric Regulation. It discusses some of the potential drawbacks and detrimental consequences of implementing the new European regulation, and the prospects of avoiding these by critically evaluating the difficulties experienced by the US.
Incidence of therapy-related acute leukaemia in mitoxantrone-treated multiple sclerosis patients in Germany
Authors: Stroet Anke , Hemmelmann Claudia , Starck Michaela , Zettl Uwe , Dörr Jan , Paul Friedemann , Flachenecker Peter , Fleischer Vinzenz , Zipp Frauke , Nückel Holger , Kieseier Bernd C , Ziegler Andreas , Gold Ralf , Chan Andrew 
Published: January 2012

Background: The incidence of therapy-related acute leukaemia (TRAL) in mitoxantrone treatment in multiple sclerosis (MS) is controversially discussed. Methods and results: In a retrospective meta-analysis from six centres, we observed six cases of acute myeloid leukaemia (AML) (incidence 0.41% for patients with mean follow up after end of treatment of 3.6 years, n = 1.156; incidence 0.25% for all patients, n = 2.261). Potential influencing factors such as myelotoxic or glucocorticosteroid pretreatment/cotreatment were present in all but one case of TRAL. Between 1990 and 2010, 11 cases of TRAL were reported to the Drug Commission of the German Medical Association (estimated risk of 0.09–0.13%). Conclusions: Regional differences in reported TRAL incidence may point to confounding cofactors such as administration protocols and cotreatments.