bluuebunny/crossref_metadata_2025_split huggingface dataset:
The protective effect of antimalarial drugs on thrombovascular events in systemic lupus erythematosus
Authors: Jung Hyejung , Bobba Raja , Su Jiandong , Shariati‐Sarabi Zhaleh , Gladman Dafna D. , Urowitz Murray , Lou Wendy , Fortin Paul R. 
Published: January 2010

AbstractObjectiveThe antimalarial medication hydroxychloroquine has been proposed as a thromboprotective agent in systemic lupus erythematosus (SLE), but studies thus far have been limited by the possibility of confounding by indication. This study was conducted to assess whether exposure to antimalarial drugs is associated with a decrease in thrombovascular events (TEs) in patients with SLE.MethodsThe study was designed as a nested case–control study embedded in an inception cohort of patients with SLE, which allowed adjustments for possible confounding by calendar year, duration of disease, duration of observation, and severity of lupus. After controlling for the possible confounding variables in conditional logistic regression models, the use of antimalarial drugs was assessed for its effects on the development of TEs in lupus patients.ResultsFifty‐four cases of TE were identified, and these were matched with 108 control subjects (lupus patients without TEs). Univariate analyses identified older age (odds ratio [OR] 1.04, 95% confidence interval [95%CI] 1.01–1.07) or being older than age 50 years (OR 3.5, 95% CI 1.4–8.6) and ever having hypertension (OR 2.5, 95% CI 1.0–5.8) as being associated with an increased risk of TEs, whereas use of antimalarial drugs (OR 0.31, 95% CI 0.13–0.71) was associated with a decreased risk of TEs. Separate analyses were done for arterial and venous TEs, which yielded similar results. In multivariate analyses, use of antimalarial drugs (OR 0.32, 95% CI 0.14–0.74) and older age (OR 1.04, 95% CI 1.01–1.07) were the only 2 variables that remained significant.ConclusionThe results from this nested case–control study demonstrate that, after accounting for the effects of disease severity, disease duration, and calendar year, antimalarial drugs were found to be thromboprotective, being associated with a 68% reduction in the risk of all TEs, with a range of risk reduction of at least 26% up to as high as 86%.
Gene expression profiling in autoantibody‐positive patients with arthralgia predicts development of arthritis
Authors: van Baarsen Lisa G. M. , Bos Wouter H. , Rustenburg François , van der Pouw Kraan Tineke C. T. M. , Wolbink Gerrit Jan J. , Dijkmans Ben A. C. , van Schaardenburg Dirkjan , Verweij Cornelis L. 
Published: January 2010

AbstractObjectiveTo identify molecular features associated with the development of rheumatoid arthritis (RA), to understand the pathophysiology of preclinical development of RA, and to assign predictive biomarkers.MethodsThe study group comprised 109 anti–citrullinated protein antibody (ACPA)– and/or rheumatoid factor–positive patients with arthralgia who did not have arthritis but were at risk of RA, and 25 patients with RA. The gene expression profiles of blood samples obtained from these patients were determined by DNA microarray analysis and quantitative polymerase chain reaction.ResultsIn 20 of the 109 patients with arthralgia who were at risk of RA, arthritis developed after a median of 7 months. Gene expression profiling of blood cells revealed heterogeneity among the at‐risk patients, based on differential expression of immune‐related genes. This report is the first to describe gene signatures relevant to the development of arthritis. Signatures significantly associated with arthritis development were involved in interferon (IFN)–mediated immunity, hematopoiesis, and chemokine/cytokine activity. Logistic regression analysis revealed that the odds ratio (OR) for developing arthritis within 12 months was 21.0 (95% confidence interval [95% CI] 2.8–156.1 [P = 0.003]) for the subgroup characterized by increased expression of genes involved in IFN‐mediated immunity and/or cytokine/chemokine‐activity. Genes involved in B cell immunology were associated with protection against progression to arthritis (OR 0.38, 95% CI 0.21–0.70 [P = 0.002]). These processes were reminiscent of those in patients with RA, implying that the preclinical phase of disease is associated with features of established disease.ConclusionThe results of this study indicate that IFN‐mediated immunity, hematopoiesis, and cell trafficking specify processes relevant to the progression of arthritis independent of ACPA positivity. These findings strongly suggest that certain gene signatures have value for predicting the progression to arthritis, which will pave the way to preventive medicine.
Trefoil factor 3 is induced during degenerative and inflammatory joint disease, activates matrix metalloproteinases, and enhances apoptosis of articular cartilage chondrocytes
Authors: Rösler Sophie , Haase Tobias , Claassen Horst , Schulze Ute , Schicht Martin , Riemann Dagmar , Brandt Jörg , Wohlrab David , Müller‐Hilke Brigitte , Goldring Mary B. , Sel Saadettin , Varoga Deike , Garreis Fabian , Paulsen Friedrich P. 
Published: January 2010

AbstractObjectiveTrefoil factor 3 (TFF3, also known as intestinal trefoil factor) is a member of a family of protease‐resistant peptides containing a highly conserved motif with 6 cysteine residues. Recent studies have shown that TFF3 is expressed in injured cornea, where it plays a role in corneal wound healing, but not in healthy cornea. Since cartilage and cornea have similar matrix properties, we undertook the present study to investigate whether TFF3 could induce anabolic functions in diseased articular cartilage.MethodsWe used reverse transcriptase–polymerase chain reaction, Western blot analysis, and immunohistochemistry to measure the expression of TFF3 in healthy articular cartilage, osteoarthritis (OA)–affected articular cartilage, and septic arthritis–affected articular cartilage and to assess the effects of cytokines, bacterial products, and bacterial supernatants on TFF3 production. The effects of TFF3 on matrix metalloproteinase (MMP) production were measured by enzyme‐linked immunosorbent assay, and effects on chondrocyte apoptosis were studied by caspase assay and annexin V assay.ResultsTrefoil factors were not expressed in healthy human articular cartilage, but expression of TFF3 was highly up‐regulated in the cartilage of patients with OA. These findings were confirmed in animal models of OA and septic arthritis, as well as in tumor necrosis factor α– and interleukin‐1β–treated primary human articular chondrocytes, revealing induction of Tff3/TFF3 under inflammatory conditions. Application of the recombinant TFF3 protein to cultured chondrocytes resulted in increased production of cartilage‐degrading MMPs and increased chondrocyte apoptosis.ConclusionIn this study using articular cartilage as a model, we demonstrated that TFF3 supports catabolic functions in diseased articular cartilage. These findings widen our knowledge of the functional spectrum of TFF peptides and demonstrate that TFF3 is a multifunctional trefoil factor with the ability to link inflammation with tissue remodeling processes in articular cartilage. Moreover, our data suggest that TFF3 is a factor in the pathogenesis of OA and septic arthritis.
The gross anatomy course: An analysis of its importance
Authors: Böckers Anja , Jerg‐Bretzke Lucia , Lamp Christoph , Brinkmann Anke , Traue Harald C. , Böckers Tobias M. 
Published: January 2010

AbstractThe gross anatomy dissection course is a cost‐intensive piece of undergraduate medical education that students and professionals alike describe as very important within the overall medical curriculum. We sought to understand more explicitly students' valuation of gross anatomy as an “important” course and so developed a quantitative longitudinal questionnaire. Medical students (n = 124) enrolled in the winter term 2006/2007 gross anatomy course at the Ulm University Faculty of Medicine were surveyed anonymously prior to, in the middle of, and at the end of the dissection course. Subgroups of students expressing rising or falling opinions of course value were identified and correlated with student opinions about the course's ability to convey professional competencies. Five‐point Likert scales were used for each survey item, which included such standardized instruments as the NeoFFI, BSI, and FBM. The study confirmed that medical students believe dissection to be valuable. Students indicated that participation in the course facilitated acquisition of anatomy knowledge as well as skills related to teamwork, coping with stress, and, to a lesser extent, time management. Students also noted that they developed less empathy than expected beforehand. Significant subgroup differences were observed relative to the competencies of teamwork, stress coping strategies, and empathy, as well as in students' stress levels associated with having to take a dissection course. Our study builds on previous work that has shown dissection courses help students develop professional competencies. The increase in professionalism might be a reason for the generally high value students place on the gross anatomy dissection course, Anat Sci Educ 3:3–11, 2010. © 2010 American Association of Anatomists.
Blue Fluorescent Amino Acids as In Vivo Building Blocks for Proteins
Authors: Merkel Lars , Hoesl Michael G. , Albrecht Marcel , Schmidt Andreas , Budisa Nediljko 
Published: January 2010

AbstractIn vivo expression of colored proteins without post‐translational modification or chemical functionalization is highly desired for protein studies and cell biology. Cell‐permeable tryptophan analogues, such as azatryptophans, have proved to be almost ideal isosteric substitutes for natural tryptophan in cellular proteins. Their unique spectral features, such as markedly red‐shifted fluorescence, are transmitted into protein structures upon incorporation. Among the azaindoles under study (2‐, 4‐, 5‐, 6‐, and 7‐azaindole) 4‐azaindole has exhibited the largest Stokes shift (∼130 nm) in steady‐state fluorescence measurements. It is also highly biocompatible and as 4‐azatryptophan it can be translated into target protein sequences. However, its quantum yield and fluorescence intensity are still significantly lower when compared with natural indole/tryptophan. Since azatryptophans are hydrophilic, their presence in the hydrophobic core of proteins could be harmful. In order to overcome these limitations we have performed nitrogen methylation of azaindoles and generated mono‐ and dimethylated azaindoles. Some of these methyl derivatives retain the pronounced red shift present in the parent 4‐azaindole, but with much higher fluorescence intensity (reaching the level of indole/tryptophan). Therefore, the blue fluorescence of azaindole‐containing proteins could be further enhanced by the use of methylated analogues. Further substitution of any azaindole ring with either endo‐ or exocyclic nitrogen will not yield a spectral fluorescence maximum shift beyond 450 nm under steady‐state conditions in the physiological milieu. However, green fluorescence is a special feature of tautomeric species of azaindoles in various nonaqueous solvents. Thus, the design or evolution of the protein interior combined with the incorporation of these azaindoles might lead to the generation of specific chromophore microenvironments that facilitate tautomeric or protonated/deprotoned states associated with green fluorescence.
A Computational Study of the Olefin Epoxidation Mechanism Catalyzed by Cyclopentadienyloxidomolybdenum(VI) Complexes
Authors: Comas‐Vives Aleix , Lledós Agustí , Poli Rinaldo 
Published: January 2010

AbstractA DFT analysis of the epoxidation of C2H4 by H2O2 and MeOOH (as models of tert‐butylhydroperoxide, TBHP) catalyzed by [Cp*MoO2Cl] (1) in CHCl3 and by [Cp*MoO2(H2O)]+ in water is presented (Cp*=pentamethylcyclopentadienyl). The calculations were performed both in the gas phase and in solution with the use of the conductor‐like polarizable continuum model (CPCM). A low‐energy pathway has been identified, which starts with the activation of ROOH (R=H or Me) to form a hydro/alkylperoxido derivative, [Cp*MoO(OH)(OOR)Cl] or [Cp*MoO(OH)(OOR)]+ with barriers of 24.9 (26.5) and 28.7 (29.2) kcal mol−1 for H2O2 (MeOOH), respectively, in solution. The latter barrier, however, is reduced to only 1.0 (1.6) kcal mol−1 when one additional water molecule is explicitly included in the calculations. The hydro/alkylperoxido ligand in these intermediates is η2‐coordinated, with a significant interaction between the Mo center and the Oβ atom. The subsequent step is a nucleophilic attack of the ethylene molecule on the activated Oα atom, requiring 13.9 (17.8) and 16.1 (17.7) kcal mol−1 in solution, respectively. The corresponding transformation, catalyzed by the peroxido complex [Cp*MoO(O2)Cl] in CHCl3, requires higher barriers for both steps (ROOH activation: 34.3 (35.2) kcal mol−1; O atom transfer: 28.5 (30.3) kcal mol−1), which is attributed to both greater steric crowding and to the greater electron density on the metal atom.
ChemInform Abstract: Giant Magnetocaloric Effect in Tb3Rh.
Authors: Talik E. , Klimczak M. 
Published: January 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Hydrothermal Syntheses, Crystal Structure and Thermal Behavior of [(CH3)2NH2]2 [B5O6(OH)4]2· [HCON(CH3)2] and [NH3CH2CH2NH3]2 [B14O20(OH)6].
Authors: Li Ping , Liu Zhihong 
Published: January 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: A New Ternary Arsenide Eu20Ni42As31: Preparation, Crystal Structure and Physical Properties.
Authors: Babizhetskyy Volodymyr , Hiebl Kurt , Simon Arndt 
Published: January 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Organic Solvent‐Free Direct Asymmetric Aldol Reactions Catalyzed by a Siloxy Serine Organocatalysts in Brine.
Authors: Teo Yong‐Chua , Lee Peter Peng‐Foo 
Published: January 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Organocatalytic Peroxy‐Asymmetric Allylic Alkylation.
Authors: Feng Xin , Yuan Yu‐Qing , Cui Hai‐Lei , Jiang Kun , Chen Ying‐Chun 
Published: January 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Pyranylium Salts as Synthones in the Synthesis of Substituted Benzenes.
Authors: Razus Alexandru C. , Nica Simona , Dragu Eugenia Andreea 
Published: January 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Efficient Routes to Pyrazolo[3,4‐b]indoles and Pyrazolo[1,5‐a]benzimidazoles via Palladium‐ and Copper‐Catalyzed Intramolecular C—C and C—N Bond Formation.
Authors: Kumar Sarvesh , Ila Hiriyakkanavar , Junjappa Hiriyakkanavar 
Published: January 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Allylic and Allenic Halide Synthesis via NbCl5‐ and NbBr5‐Mediated Alkoxide Rearrangements.
Authors: Ravikumar P. C. , Yao Lihua , Flemming Fraser F. 
Published: January 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Revisiting the Meerwein—Ponndorf—Verley Reduction: A Sustainable Protocol for Transfer Hydrogenation of Aldehydes and Ketones.
Authors: Polshettiwar Vivek , Varma Rajender S. 
Published: January 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis of a New Conjugated 2,2′‐(1,4‐Phenylenedivinylene)bisquinoxaline and a Series of Styryl Derivatives of Quinoxaline and Quinoline as Promising Electro‐ and Photoluminescent Materials.
Authors: Bachowska B. , Matusiak G. 
Published: January 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: LIC‐KOR‐Promoted Synthesis of Alkoxydienyl Amines: An Entry to 2,3,4,5‐Tetrasubstituted Pyrroles.
Authors: Blangetti Marco , Deagostino Annamaria , Prandi Cristina , Tabasso Silvia , Venturello Paolo 
Published: January 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Ligand‐Free Iron/Copper‐Cocatalyzed Amination of Aryl Iodides.
Authors: Wu Xiao‐Feng , Darcel Christophe 
Published: January 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Soluble Polymer‐Supported Organocatalysts: Asymmetric Reduction of Imines with Trichlorosilane Catalyzed by an Amino Acid Derived Formamide Anchored to a Soluble Polymer.
Authors: Malkov Andrei V. , Figlus Marek , Prestly Mark R. , Rabani Gouher , Cooke Graeme , Kocovsky Pavel 
Published: January 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Aryl tert‐Butyl Sulfoxide‐Promoted Highly Enantioselective Addition of Allyltrichlorosilane to Aldehydes.
Authors: Wang Peng , Chen Junmin , Cun Linfeng , Deng Jingen , Zhu Jin , Liao Jian 
Published: January 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: TEMPO and Carboxylic Acid Functionalized Imidazolium Salts/Sodium Nitrite: An Efficient, Reusable, Transition Metal‐Free Catalytic System for Aerobic Oxidation of Alcohols.
Authors: Miao Cheng‐Xia , He Liang‐Nian , Wang Jin‐Quan , Wang Jing‐Lun 
Published: January 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Stereoselective Synthesis of (Z)‐4‐(2‐Bromovinyl)benzenesulfonyl Azide (II) and Its Synthetic Utility for the Transformation to (Z)‐N‐[4‐(2‐Bromovinyl)benzenesulfonyl]imidates (V).
Authors: Zhang Wensheng , Kuang Chunxiang , Yang Qing 
Published: January 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: An Efficient Synthetic Method for 3,3′,4,4′‐Biphenyltetracarboxylic Anhydride.
Authors: Hu Yu Lin , Lu Ming , Liu Xiang , Wang Peng Cheng 
Published: January 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Isomerization of 7‐Oxabenzonorbornadienes into Naphthols Catalyzed by [RuCl2(CO)3]2.
Authors: Ballantine Melissa , Menard Michelle L. , Tam William 
Published: January 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: trans‐2,5‐Disubstituted Tetrahydrofurans via Addition of Carbon Nucleophiles to the Strained Bicyclic Acetal 2,7‐Dioxabicyclo[2.2.1]heptane.
Authors: Friestad Gregory K. , Lee Hye Jin 
Published: January 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Efficient Synthesis of Functionalized 2,3‐Di(alkenyl)benzothiophenes and Dibenzothiophenes Based on the First Heck Reactions of 2,3‐Di‐ and 2,3,6‐Tribromobenzothiophene.
Authors: Hussain Munawar , Malik Imran , Villinger Alexander , Langer Peter 
Published: January 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.