bluuebunny/crossref_metadata_2025_split huggingface dataset:
Early Initiation of Continuous Ambulatory Peritoneal Dialysis in Patients Undergoing Surgical Implantation of Tenckhoff Catheters
Authors: Yang Ya-Fei , Wang Huang-Joe , Yeh Chin-Chung , Lin Hsin-Hung , Huang Chiu-Ching 
Published: July 2010

Background Nephrologists commonly recommend continuous ambulatory peritoneal dialysis (CAPD) with break-in periods of at least 2 weeks. We investigated the safety and feasibility of shorter break-in periods following surgical implantation of Tenckhoff catheters. Methods We retrospectively examined 310 patients that underwent Tenckhoff catheter implantation for the first time. The early group comprised 226 patients that started CAPD ≤ 14 days after implantation; the late group comprised 84 patients that started CAPD > 14 days after implantation. Catheter-related complications within 6 months were analyzed. Results A total of 310 patients were enrolled. Time to CAPD initiation was shorter in the early group (2.0 ± 2.7 days) than in the late group (40.6 ± 42.8 days) ( p < 0.001). The bridge hemodialysis rate was higher in the late group (57.1%) than in the early group (31.4%) ( p < 0.001). Overall, 33 early-group (14.6%) and 11 late-group patients (13.1%) developed catheter-related complications within 6 months. The early-group complications were leakage ( n = 5), diminished outflow volume ( n = 7), migration ( n = 7), pericatheter hernia ( n = 1), hemoperitoneum ( n = 1), pericatheter infection ( n = 3), and peritonitis ( n = 9). The late-group complications were leakage ( n = 2), diminished outflow volume ( n = 5), migration ( n = 2), and peritonitis ( n = 2). Actuarial freedom from catheter-related complications was similar in both groups (log rank, p = 0.76). Conclusion Early initiation of CAPD with surgically implanted Tenckhoff catheters is feasible and safe. Shorter break-in periods are not associated with more catheter-related complications. The data from our peritoneal dialysis population suggest that early initiation is not associated with an increased number of complications. This needs to be confirmed in a randomized trial.
How I Learned My ABCs: Action, Back to Basics, Collaboration, Discovery
Authors: Sole Mary Lou 
Published: July 2010

Background Research is essential to generate the scientific evidence for critical care nursing practice, but it is challenging to conduct research in the busy critical care environment. The challenges are even greater in a setting with limited resources for research and where nurses have not typically conducted independent clinical studies.
Objectives To detail a successful research trajectory for studying the ABCs of patient care in the critically ill: airway, breathing, and circulation.
Methods After initial studies on circulation were conducted, the research was narrowed to focus on airway management. Airway management may be a key factor in preventing ventilator-associated pneumonia because aspiration of colonized oral, gastric, and tracheal secretions is the primary cause of ventilator-associated pneumonia. Multiple descriptive, pilot, and interventional studies have been conducted; findings from each have contributed to future studies.
Results Other ABCs were critical to this research success: action, back to basics, collaboration, and discovery. It is important for researchers to be self-motivated and to take initiative to develop skills and resources for conducting clinical studies. Several guiding principles help to promote success in research: (1) generate research ideas grounded in observation and clinical practice, (2) collaborate with others, and (3) establish affiliations and partnerships. Discovery occurs in many ways: new findings to guide practice and research, resources to conduct the study, and self-discovery.
Conclusions Nursing research is not easy. However, determination and resources help nursing researchers achieve success.
Informing Digital Programs for Lupus Self‐Management Education: A Systematic Scoping Review
Authors: Carpenter Katherine , Gilman Sarah , French Melissa , Shakur Yasmine , Dunlop‐Thomas Charmayne , Cullerton Laura , Drenkard Cristina , Barbour Kamil E. , Lim S. S. 
Published: May 2024

ObjectiveWe describe the characteristics, content, and effectiveness of digital self‐management (SM) education programs for lupus and other chronic conditions to identify gaps and inform the improvement of future programs in lupus.MethodsThree bibliographic databases were searched for articles published between May 2012 and April 2022. The search was cast to capture the breadth of digital SM education programs in the following conditions: lupus, epilepsy, fibromyalgia, multiple sclerosis, sickle cell anemia, Sjögren syndrome, psoriatic arthritis, and rheumatoid arthritis. Title and abstract screening, as well as full‐text review, was conducted by two independent reviewers. Data extraction was first completed by one author charting all studies and then, a second time, by four members of the research team charting collaboratively.ResultsOf the 1,969 articles identified through the search, 14 met inclusion criteria. Two additional articles were included following bibliography review. The 16 articles represented 12 unique digital SM education programs. Programs covered five conditions: epilepsy (n = 3), fibromyalgia (n = 2), multiple sclerosis (n = 4), lupus (n = 1), and rheumatoid arthritis (n = 2). Most programs were asynchronous and internet‐based (n = 9) with a prescribed sequence of content (n = 8). Peer, technical, or specialist support was offered in seven programs. Most programs demonstrated statistically significant improvement of symptoms in the intervention group (n = 8).ConclusionThis scoping review summarizes the current landscape for digital SM education programs in lupus and similar conditions. In lupus, further investigation will fill in the gaps around digital SM education needs, user experience, and evaluation of outcomes.
Prevalence of Fibromyalgia and Widespread Pain in Psoriatic Arthritis: Association With Disease Severity Assessment in a Large US Registry
Authors: Mease Philip , Reed George , Ogdie Alexis , Pappas Dimitrios A. , Kremer Joel M. 
Published: May 2024

ObjectiveThe classic conception of pain etiology in rheumatologic disease is nociceptive pain—tissue injury and inflammation signaling through peripheral and central nerve fibers. But this can be mixed with other pain etiologies, including nociplastic, which is augmented pain experience due to central sensitization. The pain of fibromyalgia (FM) is nociplastic, occurs in 10% to 30% of patients with rheumatologic disease, and its presence can influence disease severity assessment. The objective of our study was to (1) ascertain the prevalence of FM and widespread pain (WP) in the CorEvitas psoriatic arthritis (PsA) registry as assessed by the Widespread Pain Index (WPI) and Symptom Severity Scale (SSS) questionnaires; (2) characterize the demographic and clinical factors associated with FM and WP; and (3) ascertain the association of FM and WP on the Clinical Disease Activity in Psoriatic Arthritis (cDAPSA) score and other disease activity measures.MethodsPsA registry patients completing the WPI/SSS questionnaires since May 2020, at their most recent visit recorded in the registry, were analyzed.ResultsThe analysis included 1,823 patients with PsA; 11.1% fulfilled the FM definition and 20.6% fulfilled the WP definition. Several factors were associated with the FM definition, including female sex, depression and/or anxiety, impaired function, increased body mass index, and increased number of comorbidities. cDAPSA, patient pain and global assessment, and tender joint count were twice as severe in patients with FM compared to those without.ConclusionFM prevalence is elevated in PsA and is associated with elevated disease measures, confounding reliable disease assessment for treat‐to‐target goals. Identification of FM as an influential contextual factor in disease assessment is recommended.
Efficient and Highly Stable Lateral Perovskite Single‐Crystal Solar Cells through Crystal Engineering and Weak Ion Migration
Authors: Li Dalin , Li Ning , Zou Can , Zhong Yu , Qu Yaqian , Yang Shuang , Wang Lei , Chen Yimu , Cheng Xiao , Tao Xutang , Bakr Osman M. , Chen Zhaolai 
Published: May 2024

AbstractThe lateral device structure for perovskite solar cells (PSCs) has garnered significant attention, primarily due to its elimination of the need for expensive transparent electrodes. However, the performance of lateral devices, which are more sensitive to crystal quality and charge carrier transport bottlenecks, has lagged far behind the predominant vertical PSCs. Herein, by modulating the crystal nucleation and growth processes of thin FA0.75MA0.25PbI3 (FA = formamidinium; and MA = methylammonium) single crystals, crystal quality and carrier transport are improved, resulting in a power conversion efficiency (PCE) of 12.64%, a record for lateral PSCs. Investigation of the device's stability reveals that iodide ion migration is suppressed due to a reduction in the iodide vacancy concentration combined with weak interface iodide ion migration. It is shown that the latter effect is a result of the perpendicular direction of the ion migration and the electric field in the lateral PSCs. Consequently, these lateral single‐crystal PSCs display remarkable operational stability, retaining 100% of their initial PCE after 1200 h of steady‐state output at the maximum power point voltage (Vmpp) under 1 sun illumination. This work highlights the advantages of lateral single‐crystal devices and their potential to address key ion migration issues of PSCs.
Homogenizing the Electron Extraction via Eliminating Low‐Conductive Contacts Enables Efficient Perovskite Solar Cells with Reduced Up‐Scaling Losses
Authors: Lan Zhineng , Huang Hao , Lu Yi , Qu Shujie , Wang Min , Du Shuxian , Yang Yingying , Sun Changxu , Zhang Qiang , Suo Yi , Wang Xinxin , Yan Luyao , Cui Peng , Zhao Zhiguo , Li Meicheng 
Published: May 2024

AbstractMaintaining the power conversion efficiency (PCE) of perovskite solar cells (PSCs) while enlarging the active area is necessary for their industrialization, where the key part is the uniform carrier extraction. Here, a conformal electron transport layer (ETL) is reported with eliminated low‐conductive contacts through a tailored deposition that combines chemical bath deposition and modified spin‐coating on a light‐managing textured substrate. The KPFM and C‐AFM are utilized to prove the uniform and optimized electrical properties. This study further employs the 2D measurements of PL and TRPL mapping to focus on revealing the enhanced uniformity of electron extraction. The uniform ETL conductivity and electron extraction contribute to a substantial decrease in device up‐scaling losses, making the δPCE ( between 0.08 cm2‐device and 1 cm2‐device decrease from 5.02% to 2.97%, while the perovskite film is deposited using two‐step method. When using one‐step method to deposit perovskite film, PCEs of 25.13% and 23.93% for the active area of 0.08 cm2 and 1 cm2 are achieved, and the δPCE decreases from 7.89% to 4.77%, validating the significant effects on reducing up‐scaling losses. This work provides a new perspective to maintain high efficiency while device up‐scaling, providing more opportunities to push forward the PSCs industrialization.
From Quinary Co–Cu–Mo–Pd–Re Materials Libraries to Gas Diffusion Electrodes for Alkaline Hydrogen Evolution
Authors: Wang Xin , Cechanaviciute Ieva A. , Banko Lars , Pokharel Saika , Quast Thomas , Ludwig Alfred , Krysiak Olga , Schuhmann Wolfgang 
Published: May 2024

AbstractDeveloping a hydrogen evolution reaction (HER) electrocatalyst that can steadily drive a large current density is of great significance for industrial electrochemical water‐splitting technology. Herein, the compositionally complex noble‐metal‐lean system Co–Cu–Mo–Pd–Re is investigated for alkaline HER by a scanning droplet cell‐assisted high‐throughput screening of co‐sputtered thin‐film material libraries. The identified hit compositions are used to prepare a catalyst‐coated Ni foam‐based layer that is hot‐pressed with a specifically designed PEEK‐covered carbon‐based gas diffusion layer to obtain a novel‐design gas diffusion electrode (GDE). H2 bubbles that collect on the electrode surface are effectively reduced by controlling the hydrophobicity of the catalyst layer of the GDE, hence enabling a high current (−1 A cm−2) operation for HER in alkaline water electrolysis.
Inhaled NIR‐II Nanocatalysts for Real‐Time Monitoring and Immunomodulatory Therapy of Acute Lung Injury
Authors: Li Yi , Liu Dongfang , Chen Ting , Song Jianwen , Yu Xuya , Liu Qian , Qi Ji , Li Wen 
Published: May 2024

AbstractAcute lung injury (ALI) poses a significant and escalating medical challenge, where precise diagnosis and timely intervention hold utmost importance in halting its deterioration. Nevertheless, persistent obstacles arise from the lack of agents proficient in both real‐time diagnosis and efficient mitigation of ALI. Here, a biocatalytic and second near‐infrared (NIR‐II) fluorescence‐illuminating nanoplatform is designed to simultaneously facilitate real‐time monitoring and robust inflammation alleviation in ALI. The study first develops a new aggregation‐induced emission luminogen with trifluoromethyl substitutions, which simultaneously increase NIR‐II emission wavelength and fluorescence brightness. The molecular probe is further integrated into biocatalytic hollow ceria nanostructures, and cloaked with pre‐activated macrophage membranes for targeted inflammation intervention. Upon inhalation administration in ALI mice, the theranostic nanoagents leverage the bright NIR‐II emission and active inflammation‐tropic properties for in vivo sensitive NIR‐II imaging of ALI, which also facilitates real‐time tracking of the nanoagents’ distribution and dynamic fate within pneumonia milieu. Concurrently, the catalytic prowess of the nanoplatforms efficaciously scavenges excess reactive oxygen species, dampens proinflammatory cytokines, and promotes macrophage repolarization, substantially alleviating acute lung damage. The multifaceted nanoplatform integrates NIR‐II bioimaging with nanocatalysis‐mediated immunoregulation, offering a versatile and promising approach for addressing the intricate challenges posed by acute inflammation diseases.
Ferroelectricity with Long ion Displacements in Crystals of Non‐Polar Point Groups
Authors: Sheng Yuxuan , Wu Menghao , Liu Jun‐Ming 
Published: May 2024

AbstractIn the classical model, ferroelectricity is associated with small ion displacements from paraelectric phases with high symmetry, and ferroelectric crystals must adopt one of the ten polar point groups with low symmetry according to Neumann's principle. In this work, it is proposed that this conclusion is based on perfect bulk crystals without taking the boundaries into account. First‐principles evidence shows that ferroelectric polarizations may also be formed in some non‐polar point groups as the edges generally break the crystal symmetry. Meanwhile, such polarizations can be maintained at macroscale and are switchable when the transition between multiple equivalent states with high symmetry can be realized via long ion displacements， essentially akin to ion conductors. For example, the switching barriers can be much reduced in sliding ferroelectric bilayer systems or ionic compounds with covalent‐like directionality. Such unconventional ferroelectricity can be attributed to the boundaries and long ion displacements, and its existence in several systems like CuCrS2 is supported by experimental observations. It may explain a series of unclarified phenomena reported previously as well as significantly expand the scope of ferroelectrics, especially those with high polarizations induced by long ion displacements.
Ga2O3 Photon‐Controlled Diode for Sensitive DUV/X‐Ray Detection and High‐Resolution Array Imaging Application
Authors: Peng Zhixin , Hou Xiaohu , Han Zhao , Gan Zhiyu , Li Chen , Wu Feihong , Bai Shiyu , Yu Shujie , Liu Yan , Yang Kai , Feng Xiao , Zhan Haoyan , Zhao Xiaolong , Xu Guangwei , Long Shibing 
Published: May 2024

AbstractSensitive high‐energy photon detection from UV to X‐ray and high‐resolution array imaging are critical for medical diagnosis, space exploration, and scientific research. The key challenges for high‐performance photodetector and imaging arrays are the effective material and device design strategies for the miniaturization and integration of the device. Here, photon‐controlled diodes (i.e., the detector has rectifying characteristics only under light irradiation) are proposed for high‐resolution and anti‐crosstalk array imaging applications without integrating the switching element. Based on ultra‐wide bandgap semiconductor Ga2O3, the sensitive DUV/X‐ray photon‐controlled diodes are realized by the design of high‐resistance Ga2O3 film and high‐barrier contact. The device exhibits remarkable detection performance, including high photo‐responsivity (168 A W−1) and specific detectivity (1.45 × 1015 Jones) under DUV illumination, as well as a high sensitivity (1.23 × 105 µC Gyair−1 cm−2) under X‐ray light. Moreover, the low dark current and excellent rectification characteristics are obtained. Furthermore, its potential for high‐density and anti‐crosstalk array imaging applications is verified. These results not only bring forth new insights in the implementation of high‐performance DUV/X‐ray photodetector, but also pave a feasible way to realize high pixel density detector array through the simplified fabrication process for high‐resolution imaging applications.
Structural Defect‐Enabled Magnetic Neutrality Nanoprobes for Ultra‐High‐Field Magnetic Resonance Imaging of Isolated Tumor Cells in Vivo
Authors: Du Hui , Wang Qiyue , Zhang Bo , Liang Zeyu , Huang Canyu , Shi Dao , Li Fangyuan , Ling Daishun 
Published: May 2024

AbstractThe identification of metastasis “seeds,” isolated tumor cells (ITCs), is of paramount importance for the prognosis and tailored treatment of metastatic diseases. The conventional approach to clinical ITCs diagnosis through invasive biopsies is encumbered by the inherent risks of overdiagnosis and overtreatment. This underscores the pressing need for noninvasive ITCs detection methods that provide histopathological‐level insights. Recent advancements in ultra‐high‐field (UHF) magnetic resonance imaging (MRI) have ignited hope for the revelation of minute lesions, including the elusive ITCs. Nevertheless, currently available MRI contrast agents are susceptible to magnetization‐induced strong T2‐decaying effects under UHF conditions, which compromises T1 MRI capability and further impedes the precise imaging of small lesions. Herein, this study reports a structural defect‐enabled magnetic neutrality nanoprobe (MNN) distinguished by its paramagnetic properties featuring an exceptionally low magnetic susceptibility through atomic modulation, rendering it almost nonmagnetic. This unique characteristic effectively mitigates T2‐decaying effect while concurrently enhancing UHF T1 contrast. Under 9 T MRI, the MNN demonstrates an unprecedentedly low r2/r1 value (≈1.06), enabling noninvasive visualization of ITCs with an exceptional detection threshold of ≈0.16 mm. These high‐performance MNNs unveil the domain of hitherto undetectable minute lesions, representing a significant advancement in UHF‐MRI for diagnostic purposes and fostering comprehensive metastasis research.
Polyacrylonitrile as an Efficient Transfer Medium for Wafer‐Scale Transfer of Graphene
Authors: Shang Mingpeng , Bu Saiyu , Hu Zhaoning , Zhao Yixuan , Liao Junhao , Zheng Chunyang , Liu Wenlin , Lu Qi , Li Fangfang , Wu Haotian , Shi Zhuofeng , Zhu Yaqi , Xu Zhiying , Guo Bingbing , Yu Beiming , Li Chunhu , Zhang Xiaodong , Xie Qin , Yin Jianbo , Jia Kaicheng , Peng Hailin , Lin Li , Liu Zhongfan 
Published: May 2024

AbstractThe disparity between growth substrates and application‐specific substrates can be mediated by reliable graphene transfer, the lack of which currently strongly hinders the graphene applications. Conventionally, the removal of soft polymers, that support the graphene during the transfer, would contaminate graphene surface, produce cracks, and leave unprotected graphene surface sensitive to airborne contaminations. In this work, it is found that polyacrylonitrile (PAN) can function as polymer medium for transferring wafer‐size graphene, and encapsulating layer to deliver high‐performance graphene devices. Therefore, PAN, that is compatible with device fabrication, does not need to be removed for subsequent applications. The crack‐free transfer of 4 in. graphene onto SiO2/Si wafers, and the wafer‐scale fabrication of graphene‐based field‐effect transistor arrays with no observed clear doping, uniformly high carrier mobility (≈11 000 cm2 V−1 s−1), and long‐term stability at room temperature, are achieved. This work presents new concept for designing the transfer process of 2D materials, in which multifunctional polymer can be retained, and offers a reliable method for fabricating wafer‐scale devices of 2D materials with outstanding performance.
A Hemoglobin Bionics‐Based System for Combating Antibiotic Resistance in Chronic Diabetic Wounds via Iron Homeostasis Regulation
Authors: Sun Yihan , Liu Manxuan , Sun Weihong , Tang Xiaoduo , Zhou Yanmin , Zhang Junhu , Yang Bai 
Published: May 2024

AbstractOwing to the increased tissue iron accumulation in patients with diabetes, microorganisms may activate high expression of iron‐involved metabolic pathways, leading to the exacerbation of bacterial infections and disruption of systemic glucose metabolism. Therefore, an on‐demand transdermal dosing approach that utilizes iron homeostasis regulation to combat antimicrobial resistance is a promising strategy to address the challenges associated with low administration bioavailability and high antibiotic resistance in treating infected diabetic wounds. Here, it is aimed to propose an effective therapy based on hemoglobin bionics to induce disturbances in bacterial iron homeostasis. The preferred “iron cargo” is synthesized by protoporphyrin IX chelated with dopamine and gallium (PDGa), and is delivered via a glucose/pH‐responsive microneedle bandage (PDGa@GMB). The PDGa@GMB downregulates the expression levels of the iron uptake regulator (Fur) and the peroxide response regulator (perR) in Staphylococcus aureus, leading to iron nutrient starvation and oxidative stress, ultimately suppressing iron‐dependent bacterial activities. Consequently, PDGa@GMB demonstrates insusceptibility to genetic resistance while maintaining sustainable antimicrobial effects (>90%) against resistant strains of both S. aureus and E. coli, and accelerates tissue recovery (<20 d). Overall, PDGa@GMB not only counteracts antibiotic resistance but also holds tremendous potential in mediating microbial‐host crosstalk, synergistically attenuating pathogen virulence and pathogenicity.