bluuebunny/crossref_metadata_2025_split huggingface dataset:
Early Detection of Alterations in the Resonance Frequency Assessment of Oral Implant Stability on Various Bone Types: A Clinical Study
Authors: Şençimen Metin , Gülses Aydın , Özen Jülide , Dergin Cem , Okçu Kemal Murat , Ayyıldız Simel , Altuğ Hasan Ayberk 
Published: March 2010

AbstractThis study was undertaken to evaluate the relation between bone quality and alterations of implant stability quotient values measured during the initial phase of healing. Nineteen patients treated with 106 implants were included in the current study. The mean bone density of the implant recipient area was measured using Simplant 11 software incorporated in the computerized tomography (CT) machine. Mean bone density measurements were recorded in Hounsfield units. The implant recipient sites were subdivided into 5 groups according to bone quality. The numbers of the structures on the recipient site belonging to D1 and D5 types showed no statistical significance and were excluded. Standard 2-stage surgical technique was utilized to prepare the surgical sites. The implant stability quotient (ISQ) value at implant placement was recorded and did not influence the treatment procedure. The ISQ was measured by an Osstell instrument. The ISQ was further registered on the 21st and 60th days. SPSS statistical software was used for the statistical analysis. In comparison with the time of insertion, the mean values of the ISQ were decreasing for the first 21 days. However, on subsequent days, the ISQ values of all bone types have increased and on the 60th day reached the values recorded at the time of insertion. Analysis of the relation between changes in stability and bone type does not reveal statistical significance. With knowledge of the current clinical study, it can be concluded that bone quality in the recipient bone site does not effect changes in implant stability at the early stages of the osseointegration process.
Cyclophosphamide Dose Intensification May Circumvent Anthracycline Resistance of p53 Mutant Breast Cancers
Authors: Lehmann-Che Jacqueline , André Fabrice , Desmedt Christine , Mazouni Chafika , Giacchetti Sylvie , Turpin Elisabeth , Espié Marc , Plassa Louis-François , Marty Michel , Bertheau Philippe , Sotiriou Christos , Piccart Martine , Symmans W. Fraser , Pusztai Lajos , Thé Hugues 
Published: March 2010

Abstract

Learning Objectives
After completing this course, the reader will be able to: Analyze the role of p53 mutation in ER-negative tumors in conferring increased sensitivity to high-dose alkylating agents, in order to treat patients with this phenotype using regimens containing high-dose alkylating agents.Evaluate the role played by dysfunctional p53 in conferring chemosensitivity to anthracyclines, and explore the possibility of using high-dose alkylating agents to overcome the resistance of ER+/p53 mutated tumors.Examine the mechanism for determining p53 gene function (functional analysis of separated alleles in yeast as opposed to immunohistochemistry) to more precisely determine the role of p53 activation in specific tumors, in order to select appropriate patients for treatment with high-dose alkylating agents.
This article is available for continuing medical education credit at CME.TheOncologist.com
The predictive value of p53 for the efficacy of front-line anthracycline-based chemotherapy regimens has been a matter of significant controversy. Anthracyclines are usually combined with widely different doses of alkylating agents, which may significantly modulate tumor response to these combinations. We analyzed three series of de novo stage II–III breast cancer patients treated front line with anthracycline-based regimens of various cyclophosphamide dose intensities: 65 patients with estrogen receptor (ER)− tumors treated with anthracyclines alone (Institut Jules Bordet, Brussels), 51 unselected breast cancer patients treated with intermediate doses of cyclophosphamide (MD Anderson Cancer Center, Houston, TX), and 128 others treated with a dose-dense anthracycline–cyclophosphamide combination (St. Louis, Paris). After chemotherapy and surgery, pathologic complete response (pCR) was evaluated. p53 status was determined by a yeast functional assay on the pretreatment tumor sample. In a multivariate analysis of the pooled results, a lack of ER expression and high-dose cyclophosphamide administration were associated with a higher likelihood of pCR. A sharp statistical interaction was detected between p53 status and cyclophosphamide dose intensity. Indeed, when restricting our analysis to patients with ER− tumors, we confirmed that a mutant p53 status was associated with anthracycline resistance, but found that p53 inactivation was required for response to the dose-intense alkylating regimen. The latter allowed very high levels of pCR in triple-negative tumors. Thus, our data strongly suggest that cyclophosphamide dose intensification in ER− p53-mutated breast cancer patients could significantly improve their response.
Do Oncologists Engage in Bereavement Practices? A Survey of the Israeli Society of Clinical Oncology and Radiation Therapy (ISCORT)
Authors: Corn Benjamin W. , Shabtai Esther , Merimsky Ofer , Inbar Moshe , Rosenbaum Eli , Meirovitz Amichay , Wexler Isaiah D. 
Published: March 2010

Abstract

Learning Objectives
After completing this course, the reader will be able to: Examine the level of involvement of oncologists in bereavement rituals after a patient dies, in order to improve the effectiveness of oncologists and other caregivers in helping families cope with their loss.Analyze the reasons physicians do or do not participate in rituals involving direct contact or indirect contact with the bereaved families of their patients.Develop formal programs for the care team to provide continuing support involving direct contact and indirect contact with bereaved families.
This article is available for continuing medical education credit at CME.TheOncologist.com

Purpose.
We sought to determine the level of involvement of oncologists in bereavement rituals after a patient dies.

Subjects and Methods.
Members of the Israeli Society for Clinical Oncology and Radiation Therapy (ISCORT) were surveyed. The survey instrument consisted of questions regarding participation in bereavement rituals for patients in general and those with whom the oncologist had a special bond. Oncologists were queried as to the reasons for nonparticipation in bereavement rituals.

Results.
Nearly 70% of the ISCORT membership (126 of 182) completed the survey tool. Respondents included radiation, surgical, and medical oncologists. In general, oncologists rarely participated in bereavement rituals that involved direct contact with families such as funerals and visitations. Twenty-eight percent of physicians at least occasionally participated in rituals involving direct contact whereas 45% had indirect contact (e.g., letter of condolence) with the family on an occasional basis. There was significantly greater involvement in bereavement rituals when oncologists developed a special bond with the patient. In a stepwise linear regression model, the only factor significantly associated with greater participation in bereavement rituals was self-perceived spirituality in those claiming not to be religious. The major reasons offered for nonparticipation were time constraints, need to maintain appropriate boundaries between physicians and patients, and fear of burnout.

Conclusion.
Although many oncologists participate at least occasionally in some sort of bereavement ritual, a significant proportion of oncologists are not involved in these practices at all.
Social Security and Democracy
Authors: Mulligan Casey B , Gil Ricard , Sala-i-Martin Xavier X 
Published: March 2010

Abstract
Using some new international data sets to produce both across-country econometric estimates as well as case studies of South American and southern European countries, we find that Social Security policies vary according to economic and demographic factors but that very different political histories can result in the same Social Security policy. We find weak partial correlation between democracy and the size of Social Security budgets, on how those budgets are allocated, or how economic and demographic factors affect Social Security. If there is any observed difference between democracies and non-democracies, it is that the former spend a little less of their GDP on Social Security, grow their budgets a bit more slowly, and cap their payroll tax more often, than do economically and demographically similar non-democracies. Democracies and non-democracies are equally likely to have benefit formulas inducing retirement and, conditional on GDP per capita, equally likely to induce retirement with a retirement test vs. an earnings test.
Determination of europium by using the chemical oscillating system of Ce(IV)-KBrO3-acetone-oxalic acid-H2SO4
Authors: Gao Jinzhang , Zhang Yingying , Ren Jie , Li Ming , Yang Wu 
Published: March 2010

Abstract
A sensitive and convenient method for the determination of trace europium ions using an oscillating chemical reaction involving Ce(IV) - KBrO3 - acetone - oxalic acid - H2SO4 was proposed. The results indicated that the changes in oscillating period (T) was linearly proportional to the negative logarithmic concentration of Eu3+ (-log C) in the range of 1.41 × 10−8 ˜ 1.41 × 10−4 mol L−1 (r = 0.9982) with a detection limit of 1.04 × 10−9 mol L−1. The recoveries were limited to the range of 99.5% to 100.8%. Under the same conditions, other rare earth ions did not interfere with the determination of Eu3+. In addition, a perturbation mechanism was also discussed briefly.
RP-HPLC-DAD method for determination of olmesartan medoxomil in bulk and tablets exposed to forced conditions
Authors: Sharma Ritesh , Pancholi Shyam 
Published: March 2010

RP-HPLC-DAD method for determination of olmesartan medoxomil in bulk and tablets exposed to forced conditionsA simple, sensitive and precise RP-HPLC-DAD method was developed and validated for the determination of olmesartan medoxomil (AT-II receptor blocker) in the presence of its degradation products. Olmesartan medoxomil and all the degradation products were resolved on a C18column with the mobile phase composed of methanol, acetonitrile and water (60:15:25,V/V/V, pH 3.5 by orthophosphoric acid) at 260 nm using a photodiode array detector. The method was linear over the concentration range of 1-18 μg mL-1and precise with RSD < 1 % in intra- and inter-day study. Excellent recoveries of 99.3 ± 0.9 to 100.8 ± 1.2% proved the accuracy of the method. Developed method was specific, as indicated by chromatographic resolution > 2.0 for each peak and sensitive withLOD0.03 μg mL-1andLOQ0.1 μg mL-1. The method was used to study the drug degradation behavior under forced conditions. Four degradation products (DP-I, II, III, IV) were formed during the degradation study in 0.1 mol L-1HCl whereas only DP-I, II and III were formed in water, 0.01 mol L-1NaOH and 3% H2O2. No significant thermal or photolytic degradation was observed in solid drug. The method was applied successfully for the assay of olmesartan medoxomil in the tablet dosage form.
Krefftascaris (Nematoda, Ascaridoidea) from Australian Side-Necked Turtles with Description of Krefftascaris Sharpiloi SP. N. from Chelodina Rugosa
Authors: Tkach V. , Kuzmin Yu. , Snyder S. 
Published: March 2010

Krefftascaris(Nematoda, Ascaridoidea) from Australian Side-Necked Turtles with Description ofKrefftascaris SharpiloiSP. N. fromChelodina RugosaPreviously known records of ascaridoid nematodesKrefftascarisSprent, 1980 are summarized and new records of the genus reported.Krefftascaris sharpiloiTkach, Kuzmin et Snyder, sp. n. is described from specimens found in the stomach of the northern snake-necked turtleChelodina rugosacollected from two localities in Northern Territory, Australia. The new species differs from the only previously knownKrefftascarisspecies,K. parmenteriSprent, 1980, by the presence of thickened and bifurcated anterior edges of the lateral cuticular alae and a difference in the relative distance from the anterior end to the nerve ring which is 1.5 to 2 times greater inK. parmenteri.Comparison of approximately 2.100 bases of ribosomal DNA sequences This study contains first reports ofKrefftascarisinChelodina rugosa, Chelodina burrungandjii, Chelodina canniandEmydura tanybaragaand the first records of this genus in the Northern Territory, Queensland and Western Australia. Molecular phylogenetic analysis based on sequences of nuclear small ribosomal subunit gene has demonstrated close affinities betweenKrefftascarisandHeterocheilus, the type genus of the Heterocheilidae and Heterocheilinae. Parasitism of several species and genera of Heterocheilidae in crocodiles allows us to hypothesize thatKrefftascarismay have been acquired by turtles from crocodilians.
A New Species of Predaceous Mites of the Genus Amblyseiella (Parasitiformes, Phytoseiidae) from Ukraine
Authors: Kolodochka L. , Omeri I. 
Published: March 2010

A New Species of Predaceous Mites of the Genus Amblyseiella (Parasitiformes, Phytoseiidae) from Ukraine
A new species of phytoseiid mites Amblyseiella antonii Kolodochka et Omeri, sp. n. (Parasitiformes, Phytoseiidae) found on Juniperus sabina L. in Kyiv (Ukraine) is described. This is the first record of a representative of the genus Amblyseiella Muma from Ukraine. Description, drawings, measurements and diagnosis of the species are given.
Teacher-coach role conflict in school-based physical education in USA: a literature review and suggestions for the future
Authors: Konukman Ferman , Agbuĝa Bülent , Erdoĝan Şamil , Zorba Erdal , Demirhan Giyasettin , Yilmaz Ilker 
Published: March 2010

Teacher-coach role conflict in school-based physical education in USA: a literature review and suggestions for the future
Teaching and coaching are two different occupational roles, and teachers who also coach have stressful work environments common to all educational settings, but each occupational role has specific stress and burnout problems. The responsibilities of physical education (PE) teachers and coaches are distinguishable from one another. These different roles and role conflicts may create stress among PE teachers who also coach. The history of physical education shows that there are contextual factors that promote PE teacher-coach role conflict. The aim of this paper is to analyse these contextual factors via using a literature review analysis and to provide suggestions about teacher-coach role conflict for school-based physical education in USA.
Risk Factors for High Dialysate Glucose use in PD Patients—A Retrospective 5-Year Cohort Study
Authors: Wu Hon-Yen , Hung Kuan-Yu , Hu Fu-Chang , Chen Yung-Ming , Chu Tzong-Shinn , Huang Jenq-Wen , Wu Kwan-Dun , Tsai Tun-Jun 
Published: March 2010

Background Use of high concentrations of glucose for peritoneal dialysis (PD) may produce unfavorable results. Our previous study showed that high initial glucose load is associated with poor PD technique survival. Objective This retrospective cohort study at a medical center in Taiwan aimed to understand the factors associated with high glucose load in long-term PD patients. Patients and Methods We reviewed 90 newly started PD patients over 5 years. We determined glucose load by calculating annual glucose weight and dialysate volume administered. Multiple linear regression analyses with time-dependent covariates were used to determine factors that influence the annual average dialysate glucose concentration. Results The study group included 47 men and 43 women with a mean age of 53.4 ± 13.9 years. Technique survival rates were 91.0%, 84.1%, and 77.6% at the beginning of the second, third, and fourth year of PD therapy respectively. The presence of diabetes mellitus (DM), high body mass index (BMI), and low weekly renal Kt/V were significantly correlated with high average dialysate glucose concentration during the first, second, and third years. For patients undergoing PD for more than 3 years, residual renal function (RRF) deteriorated, and only DM significantly affected higher dialysate glucose concentration in the fourth year. Conclusions Patients with DM, high BMI, and low RRF were more likely to require a high glucose load for PD therapy, especially during the first 3 years. After those 3 years of PD, DM was the only significant factor in the need for higher glucose load. To reduce the glucose load in chronic PD patients, alternative osmotic agents such as icodextrin or amino acids should be considered in the daily PD regimen.
Complications after Tenckhoff Catheter Insertion: A Single-Centre Experience using Multiple Operators over Four Years
Authors: Liu Wen Jiun , Hooi Lai Seong 
Published: March 2010

Objective To analyze the complications after Tenckhoff catheter insertion among patients with renal failure needing dialysis. Patients and Methods The open, paramedian approach is the commonest technique to insert the 62-cm coiled double-cuffed Tenckhoff peritoneal catheter. All patients with catheters inserted between January 2004 and November 2007 were retrospectively analyzed for demographics and followed for up to 1 month for complications. We excluded patients whose catheters had been anchored to the bladder wall and who underwent concurrent omentectomy or readjustment without removal of a malfunctioning catheter ( n = 7). Intravenous cloxacillin was the standard preoperative antibiotic prophylaxis. Results Over the 4-year study period, 384 catheters were inserted under local anesthetic into 319 patients [201 women (62.8%); mean age: 49.4 ± 16.7 years (range: 13 – 89 years); 167 (52.2%) with diabetes; 303 (95%) with end-stage renal disease] by 22 different operators. All Tenckhoff catheters were inserted by the general surgical ( n = 223) or urology ( n = 161) team. There were 29 cases (7.6%) of catheter migration, 22 (5.7%) of catheter obstruction without migration, 24 (6.3%) of exit-site infection, 12 (3.1%) of leak from the main incision, 14 (3.6%) of culture-proven wound infection, 11 (2.9%) post-insertion peritonitis, and 1 (0.3%) hemoperitoneum. No deaths were attributed to surgical mishap. Conclusions The most common complication was catheter migration. The paramedian insertion technique was safe, with low complication rates.
Finding the Right Position: A Three-Year, Single-Center Experience with the “Self-Locating” Catheter
Authors: Bergamin Brigitte , Senn Oliver , Corsenca Alf , Dutkowski Philipp , Weber Markus , Wüthrich Rudolf P. , Segerer Stephan , Thut Martina Pechula 
Published: March 2010

Background Peritoneal dialysis (PD) catheter displacement is a major cause of dysfunction. Various catheter forms have been designed to improve outcome. One of them is based on the classical Tenckhoff catheter, but includes a small tungsten cylinder at the distal end to optimize location and to prevent dislocations. Methods In this retrospective study, we analyzed the functionality and complication profile of the self-locating catheter implanted at our center from November 2005 to September 2008 in our PD program. Results Data from 27 self-locating catheters implanted in 25 patients (12 women) were obtained. Patients were followed for up to 30 months (median observation time: 13 months), resulting in a cumulative study period of 357 PD months. A total of 22 complications were identified, including 1 episode of peritonitis per 52 patient–months, 1 tunnel infection, and 1 exit-site infection. The “functional catheter failure incidence rate” was approximately 0.01 catheters per month on PD (or approximately 1 catheter loss per 100 PD months). The catheter survival was 93% at 1 year. Conclusions The “self-locating” PD catheter demonstrates low rates of catheter migration and dislocations, and good catheter survival.
Risk Factors for Peritoneal Dialysis–Associated Peritonitis: The Role of Oral Active Vitamin D
Authors: Rudnicki Michael , Kerschbaum Julia , Hausdorfer Johann , Mayer Gert , König Paul 
Published: March 2010

Background Peritonitis is a major complication of peritoneal dialysis (PD), being associated with hospitalization, catheter loss, technique failure, and increased mortality. Data on various risk factors for peritonitis are inconsistent, and no association with concomitant therapy has been shown. Methods We performed a retrospective analysis of all incident and prevalent PD patients ( n = 55) treated in Innsbruck, Austria, between 2000 and 2007. Data consisted of 1291 patient–months and 55 episodes of peritonitis. Patient demographic data, comorbidities, concomitant medication, laboratory parameters, and microbiology results were obtained from the medical records and from the hospital's electronic database. Results The mean peritonitis incidence rate was 0.51 episodes/patient–year (range: 0.24 – 0.73 episodes/patient–year) or 1 episode every 23.5 months (range: 16 – 50 months). In a primary analysis including demographic characteristics, comorbidities, laboratory parameters, and concomitant medication, only treatment with oral active vitamin D was associated with a significantly lower risk of peritonitis. Adjusted for time on PD and baseline serum albumin, oral active vitamin D therapy was associated with an 80% reduced relative risk of peritonitis [hazard ratio (HR): 0.20; 95% confidence interval (CI): 0.06 to 0.64; p = 0.007)]. The risk reduction was comparable in patients who received 0.25 μg or more of vitamin D daily (HR: 0.18; 95% CI: 0.05 to 0.65; p = 0.008) and in those who received less than 0.25 μg vitamin D daily (HR: 0.21; 95% CI: 0.06 to 0.77; p = 0.018). Conclusions Treatment with oral active vitamin D might be associated with a lower risk of peritonitis in PD patients.
Interstitial Lung Disease Associated with Anti-PM/Scl or Anti-Aminoacyl-tRNA Synthetase Autoantibodies: A Similar Condition?
Authors: LEGA JEAN-CHRISTOPHE , COTTIN VINCENT , FABIEN NICOLE , THIVOLET-BÉJUI FRANÇOISE , CORDIER JEAN-FRANÇOIS 
Published: March 2010

Objective.To compare anti-PM/Scl autoantibody-associated interstitial lung disease (ILD) with anti-aminoacyl-tRNA synthetases (anti-ARS) autoantibody-associated ILD.Methods.We retrospectively studied 21 patients with ILD from a department of respiratory medicine, including 9 with anti-PM/Scl autoantibodies (6 women, median age 55 yrs, followup 5.5 yrs) and 12 with anti-ARS autoantibodies (6 women, median age 59 yrs, followup 2.3 yrs).Results.Pulmonary manifestations in patients with anti-PM/Scl autoantibody-associated ILD usually followed the extrapulmonary manifestations of the connective tissue disease (CTD) (7/9 cases). The predominant imaging features on initial high resolution computed tomography were ground-glass attenuation and reticular opacities, and mainly suggested nonspecific interstitial pneumonia in both groups. CTD was classified as dermatomyositis (DM; 2), undifferentiated CTD (2), cutaneous limited systemic sclerosis (2), rheumatoid arthritis (RA; 1), and overlap syndrome (1) in the anti-PM/Scl group; and polymyositis (4), undifferentiated CTD (5), DM (1), amyopathic DM (1), and RA (1) in the anti-ARS group. Frequencies of arthralgia, Raynaud phenomenon, cutaneous rash, and mechanic’s hands were comparable in both groups. Myalgia or muscle weakness was present in 0/9 PM/Scl and 5/12 ARS patients (p < 0.05). More than 1 autoantibody was present in 11 patients. ILD worsened despite treatment in 4 patients with anti-PM/Scl autoantibodies and 2 with anti-ARS autoantibodies, and included 1 death.Conclusion.Anti-PM/Scl and anti-ARS antibodies are associated with similar clinical manifestations, with the exception only of more overt myositis in the latter, therefore challenging the clinical specificity of the antisynthetase syndrome.