bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Piezoresistive-based 3-axial MEMS Tactile Sensor and Its Integrated Surgical Forceps for Gastrointestinal Endoscopic Minimally Invasive Surgery
Authors: Liu Huicong , Hou Cheng , Gao Huxin , Yang Xiaoxiao , Xue Guangming , Zuo Xiuli , Li Yanqing , Li Dongsheng , Lu Bo , Ren Hongliang , Sun Lining 
Published: June 2024

Abstract

In robotic-assisted surgery (RAS), traditional surgical instruments without sentient capability cannot perceive accurate operational forces during the task, and such drawbacks can be largely intensified when conducting sophisticated tasks using flexible and slender arms with small end-effectors, e.g., in gastrointestinal endoscopic surgery (GES). In this work, we propose a micro-electro-mechanical systems (MEMS) piezoresistive 3-axial tactile sensor for GES forceps, which can intuitively provide surgeons with online force feedback during robotic surgery. The fabrication process of MEMS enables the sensor chips to possess dimensions of miniaturization. The fully encapsulated tactile sensors can be effortlessly integrated into miniature GES forceps, which feature a slender diameter of just 3.5 mm and undergo meticulous calibration procedures least squares method. In experiments, the sensor's capability to accurately measure directional forces up to 1.2 N in Z axis was validated, demonstrating an average relative error of only 1.18% compared to the full-scale output. The results indicate that this tactile sensor can provide effective 3-axial force sensing during surgical operations, such as grasping and pulling, and in ex-vivo testing of the porcine stomach. Its characteristics of compact size, high precision, and integrability establish solid foundations for clinical application in the operating theatre.
The role and mechanism of CHMP4C in poor prognosis and drug sensitivity of lung adenocarcinoma
Authors: Xu Chuan , Liu Mingshan , Li Yang , Peng Xiaoyue , Zhou Wei , Zhang Wan , Zhang Jingtao , Yu Bentong 
Published: June 2024

Abstract

Background
Chromatin modified protein 4C (CHMP4C) is a charged polyvesicular protein (CHMP) that is involved in the composition of the endosomal sorting complex (ESCRT-III) required for transport III and promotes the necessary separation of daughter cells. CHMP4C involved in a wide variety of tumor progress,, such as prostate cancer, cervical cancer and lung squamous cell carcinoma. However, the value of CHMP4C in lung adenocarcinoma has not been explored.
Methods
RNA-seq data and lung adenocarcinoma clinical information and corresponding pan-cancer were extracted from The Cancer Genome Atlas (TCGA) database to analyze CHMP4C expression and survival prognosis. The differential expression of CHMP4C was analyzed using the Human Protein Atlas (HPA) database. Clinical samples were collected to verify the differential expression of CHMP4C between lung adenocarcinoma and normal lung tissues via immunohistochemical (IHC) staining, qRT‒PCR and Western blotting. Gene Ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analyses of CHMP4C-related genes were performed. The correlation between CHMP4C and chemosensitivity was analyzed in the TCGA database. Then, qRT‒PCR, western blotting, transwell assays, cell proliferation assays, colony formation assays, wound healing assays, and cell cycle analysis were used to verify the possible regulatory mechanism involved. Molecular docking was used to predict small molecule compounds with potential roles in the treatment of lung adenocarcinoma.
Results
TIMER2.0 database analysis revealed that CHMP4C was differentially expressed in different tumors.Compared with that in healthy lung tissue, CHMP4C was significantly upregulated in lung adenocarcinoma tissue, and subsequent in vitro survival analysis revealed that CHMP4C expression has significant clinical prognostic value in lung adenocarcinoma. Enrichment analysis revealed that CHMP4C was mainly related to cell proliferation, cell migration, and the PI3K-Akt signaling pathway, etc. Overexpression of CHMP4C was associated with sensitivity to chemotherapy. Knocking down CHMP4C can significantly inhibit the proliferation, migration and invasion of lung adenocarcinoma cells and prolong the G0/G1 phase of the cell cycle. Molecular docking predicts 10 key drugs that may be used for the treatment of lung adenocarcinoma.
Conclusions
CHMP4C is highly expressed in a variety of tumors.We demonstrated that CHMP4C expression may be associated with the occurrence, development, prognosis and chemotherapy sensitivity in patients with lung adenocarcinoma. These findings may open up new research directions and development opportunities for the treatment of lung adenocarcinoma.
Effects of Sarcopenia and Nutritional Status on Surgical Outcomes for Metastatic Spinal Tumors : In the Perspective of Peri-operative Complications and Performance Improvement
Authors: Bang Chungwon , Ko Myung-Sup , Ko Young-Il , Kim Young-Hoon 
Published: June 2024

Abstract

Background
With the advancement of cancer treatment, appropriate treatment for musculoskeletal problems is becoming more important as it extends the patient's lifespan and improves the quality of life. In surgical treatment for metastatic spine tumors (MST), various efforts are being considered to obtain a good prognosis. The purposes of this study are to analyze prognostic factors for postoperative ambulation and perioperative complications in patients surgically treated for MST with neurologic symptoms.
Methods
Seventy five cases of patients who underwent surgery for MST with neurologic symptoms were enrolled between December 2016 and January 2023. Postoperative ambulatory function and medical complications were assessed for each patient in this study. The endpoint of ambulatory function was defined as the best function among entire periods of follow-up outpatient visits. We defined the improvement of ambulatory function as improvement in ECOG scale. For complications, we applied complication classification system for orthopaedic surgery. Perioperative complications were defined as those requiring changes of treatment compared with routine postoperative treatment during patient’s admission. Confirmed complications included expire, delirium, urinary tract infection (UTI), pneumonia, sepsis, bacteremia, acute kidney injury (AKI), chylothorax. Prognostic factors were collected and analyzed for relationship by logistic regression.
Results
Of the 75 cases, postoperatively 42 (56%) cases of patients were improved in Nurick grade, 36 (48%) cases of patients in ECOG performance. And 21 (28%) cases of patients were treated in ICU and 15 (20%) cases of patients suffered from major perioperative complications. Regression analysis showed that clinical factors such as ECOG, PMI and PNI were related to the improvement of ambulatory function and incidence of perioperative complications. On multivariate analysis, improvement of ambulatory function was associated with PMI (p = 0.014) and incidence of perioperative complications was associated with PNI (p = 0.045).
Conclusions
Preoperative nutritional status and sarcopenia are related factors in the outcome of surgical treatment for MST, and preoperative efforts to improve these may be a way to obtain better clinical results.
Relationship between METS-IR and ABSI index and the Prevalence of Nocturia: A Cross-Sectional Analysis from the 2005-2020 NHANES Data
Authors: Xue Fei , Zhou Yating 
Published: June 2024

Abstract

Background
Nocturia, a common condition marked by frequent nighttime urination, significantly impacts quality of life. This study explores the association of metabolic index METS-IR ( Metabolic Score for Insulin Resistance) and ABSI (A Body Shape Index) with nocturia, utilizing data from the National Health and Nutrition Examination Survey (NHANES).
Methods
A cross-sectional analysis of NHANES data from 2005–2020 was performed. The associations between METS-IR, ABSI, and nocturia were evaluated using multivariable logistic regression, accounting for demographic characteristics, chronic diseases, and lifestyle factors. Generalized additive models and smoothing spline techniques described the relationship dynamics.
Results
Of the 16,450 participants, significant associations were observed between nocturia and both METS-IR (OR: 1.01, 95% CI: 1.01–1.02, p < 0.0001) and ABSI (OR: 1.03, 95% CI: 1.02–1.04, p < 0.0001). Higher quartiles of METS-IR and ABSI were associated with increased risks (OR for METS-IR Q4: 1.53, 95% CI: 1.36–1.71; OR for ABSI Q4: 1.38, 95% CI: 1.23–1.55). Stratified analyses indicated consistent patterns across demographics, with marital status impacting the ABSI-nocturia relationship. Nonlinear modeling revealed a threshold effect for ABSI at 76.2.
Conclusion
Increases in METS-IR and ABSI are closely linked with a higher prevalence of nocturia, indicating that these metabolic index can be used in clinical assessments to evaluate the risk of nocturia and support the formulation of preventive and therapeutic strategies.
Starvation influences the microbiota in the stomach of the corallivorous Crown-of-Thorns Starfish
Authors: Zhang Ying , Lai Fuxiang , Yang Litong , Su Nan , Hu Jianxing , Chen Huizhen , Gao Qian , Zheng Fanyu , Chen Chang 
Published: June 2024

Abstract

The crown-of-thorns starfish (CoTS), also known as Acanthaster spp., is responsible for a considerable amount of coral loss in the tropical Indo-Pacific region. After decimating coral populations through predation, it is anticipated that CoTS will face food scarcity before coral recovery. It is unclear how CoTS respond to starvation stress. Therefore, we conducted a four-month starvation stress experiment on CoTS, and analyzed the response characteristics of its stomach bacterial communities using high-throughput 16S rRNA sequencing technology. The results showed no significant differences in the α-diversity of the stomach bacterial community, but the β-diversity differed significantly between fed and starved CoTS. The bacterial community composition in the CoTS stomach changed dramatically, manifesting mainly from Tenericutes to Proteobacteria at the phylum level, and from a community dominated by digestive bacteria (Mycoplasma) to beneficial bacteria (Endozoicomonas) at the genus level. Furthermore, co-occurrence network analysis revealed that starvation reduced the network stability of the bacteria community, but improved network modularity, which may have contributed to the CoTS adaptation to chronic starvation. This study has provided a basis for elucidating the mechanism of starvation resistance in the crown-of-thorns starfish and will contribute to the development of new control measures for adult crown-of-thorns starfish.
A Systematic Analysis of the Burden of Disease Attributable to Occupational Noise-Induced Hearing Loss in China Based on the 2019 Global Burden of Disease Study
Authors: Wang Sirui , Liu Shuhan , Li Kaijie , Tang Wei , Fan Xiaofeng , Cheng Yongran , Dai Lili 
Published: June 2024

Abstract

Background and Purpose: Occupational noise has long been recognized as a significant risk factor for hearing loss, particularly among workers. We herein aimed to provide a comprehensive and up-to-date analysis of the temporal and sex heterogeneity in the burden of hearing loss attributable to occupational noise in China from 1990 to 2019.
Methods: We extracted data on the burden of hearing loss attributable to occupational noise from the 2019 Global Burden of Disease study. Disability-adjusted life years (DALYs) and the annual percentage change (APC) were computed. The Joinpoint regression model was used to analyze the trends in the burden of disease attributable to occupational noise exposure from 1990 to 2019 and calculate the average APC.
Results: In China, the DALYs attributable to occupational noise-induced hearing loss in 2019 were 2.3277 million [95% uncertainty interval (UI): 1.5779–3.3478 million], marking a 70.95% increase compared with that in 1990. Throughout the study period, DALY rates exhibited a declining trend, with rates of 127.7 per 100,000 (95% UI: 87.4–181.4) in 1990 and 119.8 per 100,000 (95% UI: 81.2–182.1) in 2019. Using the Joinpoint regression model, the APC in age-standardized DALY rates for occupational noise-related hearing loss initially increased from 1990 to 2000, followed by a decline, reaching its lowest point in 2015. From a sex perspective, the burden of DALYs in Chinese males exceeded that in females, although the rate of decline was less pronounced in females. With regard to age, the number and rate of DALYs attributable to occupational noise-induced hearing loss generally increased with age, particularly among middle-aged individuals and older adults . However, from 1990 to 2019, the number of DALYs attributable to occupational noise-induced hearing loss decreased among young people aged 15–19 years, accompanied by a significant reduction in DALY rates.
Conclusion: Hearing loss attributable to occupational noise represents a substantial public health concern, especially among middle-aged and older adult workers in China. These findings underscore the importance of implementing effective measures to mitigate occupational noise exposure.
Microperimetric Biofeedback Training for Children with Idiopathic Infantile Nystagmus Syndrome: a Short-and-Long Term Analysis
Authors: Misawa Mariana , Eldeeb Mohab , Pyatova Yulia , OT Michelle Markowitz , Goldsmith Max , Markowitz Samuel N. , Nido Monica Daibert 
Published: June 2024

Abstract

Microperimetric Biofeedback training (BT), a new vision rehabilitation therapy, was used to improve fixation stability, visual functions, and parental quality of life questionnaire (QoL) in children with idiopathic infantile nystagmus. The patients were followed for short and long term. 25 cases (9.3 ± 2.3 years old) trained on the MAIA microperimeter for 80 minutes delivered within 4 weekly sessions. They were followed for the short (1 week to 1 month) and long term (22 patients, from 8 months, up to 5 years). Binocular distance and near vision, fixation stability (FS), reading speed, contrast sensitivity, and QoL showed a significant improvement post-BT on short and long term. Stereopsis did not improve. Distance and near vision improved 1 ETDRS line, contrast improved 2 lines on 10% contrast Colenbrander Test, reading speed improved 22 words/minute, and QoL 1.3 points. FS could be measured in 48% of the cases, and improved 38%. BT had a significant long lasting positive effect on visual functions and QoL in children with idiopathic nystagmus. This research suggests that, as a low cost-benefit therapy, BT may become a new therapeutic option for these cases.
Using low concentration polyethylene glycol to regulate the microstructure of ink to improve the printing quality of cotton fabric
Authors: Tang Zhiyuan , Yang Xueyuan , Sun Fuyun , Zhang Kun , Fang Kuanjun 
Published: June 2024

Abstract

Satellite droplets, excessive ink spread and penetration present significant obstacles to the advancement of inkjet printing on cotton fabrics. Traditional ink preparation methods utilizing organic solvents are unable to effectively address these issues. This study addressed these challenges by investigating the polyethylene glycol (PEG) as a component in reactive dye ink. It was found that the longer the molecular chain of PEG, the more complex coil formed after dissolution, which could increase ink viscosity and inhibit satellite droplets more effective. Meanwhile, the reduction of PEG concentration promoted the swelling of ink to sodium alginate (SA) film. High swelling degree and complex PEG coil could limit ink spread and penetration. Solid state PEG further restricted ink spread and penetration during the dye fixation process. Ink prepared by 3.2 wt% PEG20000 achieved no satellite droplets, the smallest spreading area and lowest permeability, and the highest dye fixation rate. Compared to commercial ink, PEG20000/Red 218 ink demonstrated smaller spreading area and lower permeability, and higher dye fixation rate. This study introduces a promising approach for the production of high-quality, cost-effective reactive dye inks using polymer coil structure.
Stepwise extraction of zinc, indium and lead from secondary zinc oxide dusts Experimental study
Authors: WANG Guihua , DU Peipei , ZHANG LiangJin , LONG Yue , ZHANG Jiansong 
Published: June 2024

Abstract

In order to realize the stepwise extraction of Zn, In and Pb from secondary zinc oxide dust, the thermodynamic analysis of wet leaching was carried out, and the multi-stage combined wet treatment process of “low acid leaching-high acid leaching-chlorination leaching” was formulated; secondary zinc oxide dust was used as the experimental raw material to explore the optimal process conditions for the stepwise extraction of Zn, In and Pb. The experimental results show that: using low acid leaching to treat the secondary zinc oxide dust, sulfuric acid mass concentration of 100 g/L, liquid-solid product mass ratio of 5 mL/1·g, leaching time of 90 min, leaching temperature of 60 ℃, stirring speed of 500 r/min, and a single leaching conditions, the Zn leaching rate of more than 70%, the mass fraction of In, Pb increased to 0.052%, 10.8%, respectively, to achieve a 3.71 times, 2.45 times enrichment effect, respectively; When the high acid leaching treatment was used to treat the low acid leaching residue, the sulfuric acid concentration was 170 g/L, the liquid-solid volume mass ratio was 7 mL/1·g, the leaching time was 4 h, the leaching temperature was 80°C, the stirring speed was 500 r/min, the leaching rate of In was more than 90%, and the Pb mass fraction was increased to 40.12%, which achieved a comprehensive enrichment effect of 8.96 times. The high acid leaching residue was treated by chlorination leaching method, and the Pb leaching rate was greater than 93% under the conditions of pH value of 3, leaching temperature of 80°C, liquid-solid volume mass ratio of 12 ml/1·g, Cl− concentration of 7 mol/L, leaching time of 2 h, and stirring speed of 500 r/min, and the gradient separation of Zn, In and Pb was preliminarily realized.
Lora for Dense passage retrieval of ConTextual Masked Auto-Encoding
Authors: zhang Liuhong , Li Shixuan , Peng Hongxing 
Published: June 2024

Abstract

Dense Passage Retrieval (DPR) serves as a crucial initial step in improving the performance of the Retrieval Augmented Generation (RAG) paradigm for LLMs. While DPRs are challenging to train and typically involve fine-tuning (FT) on pre-trained models to enhance embedding similarity between queries and associated textual data, the utilization of LoRA in DPR remains limited. A more comprehensive understanding of DPR fine-tuning is necessary to fully leverage its potential. The goal of this research is to refine DPR through the use of PEFT's Low-Rank Adaptation (LoRA), which is used to stabilize the pre-trained model weights and introduces trainable rank decomposition matrices into each layer of the Transformer architecture. This approach has the potential to reduce the training parameters and deployment costs of the FT-based approach.The results of our experiments show that LoRA-DPR, when trained for three epochs on a Quadro RTX 8000 48GB GPU, requires only 14.32 million parameters for fine-tuning (11.64\% of full parameter fine-tuning) and outperforms full parameter fine-tuning by 0.14 percentage points on the MRR@10 of the MS-MARCO dev set.The results show that this approach performs comparably to or even outperforms full FT models on Natural Questions (NQ) and MS-MARCO datasets, addressing challenges related to resource deployment costs and lengthy training times. The source code is available at \url{https://github.com/lauren-ai/LoRA_DPR}.
Rare-Earth Magnet Ingestions in Pediatric Patients: A Multi-center Study in Qatar
Authors: Alshahwani Noora , Al-Ani Lina , Najar Safaa , Baghazal Hassan , Alishaq Fajer 
Published: June 2024

Abstract

Rare-earth magnet ingestion in the pediatric population is associated with significant injuries. Multiple reports on perforation, intestinal fistula formation, and bowel obstruction are available worldwide.
We reviewed the medical records for cases seen in Qatar from 2011 to 2024 in the main institutions providing tertiary care to all children, reviewing the demographics, clinical presentation, treatment modality, operative and postoperative course.
Of the 45 cases managed, 32(80%) required intervention (laparoscopy, laparotomy, and/or endoscopy). Among these, 20 patients (62.5%) underwent laparotomy, 4(12.5%) underwent laparoscopy as the sole or combined modality, and 4 (12.5%) were eligible for endoscopic removal only. Post-intervention complications were reported in 9 cases (28.1%), including superficial wound infection(5/32), collection(3/32), adhesive bowel obstruction (1/32), and incisional hernia(1/32). No deaths were seen. In logistic regression, presence of symptoms was the only predictive factor for the need of intervention (OR7.09 [95%CI 1.23-40.75]).
Our national report demonstrates the hazards and complications of magnet ingestion in children. Raising public awareness of the hazards and limiting access to magnets in toys would be important prevention steps. Policymakers should consider product recall to reduce these effects. Further efforts and collaboration with neighboring GCC and Arab countries should be undertaken to further reduce this issue.
Correlation between baseline optical coherence tomography angiography quantitative biomarkers and visual outcome in treatment naïve patients with neovascular age-related macular degeneration
Authors: Faghihi Shahin , Faghihi Hooshang , Bazvand Fatemeh , Bahar Mohammadreza Mehrabi , Torkashvand Ali , Ahmed Ahmed Husein , Rahimi Masoud , Akbarzadeh Ali , Khameneh Esmaeil Asadi , Pour Elias Khalili , Riazi-Esfahani Hamid 
Published: June 2024

Abstract

The study aimed to assess different choroidal neovascular network characteristics in relation to changes in best corrected visual acuity (BCVA) over 3 and 12 months following treatment. Using optical coherence tomography angiography, the choroidal neovascular complexes of 46 treatment naïve patients with neovascular age-related macular degeneration (nAMD) were evaluated. The change in BCVA from baseline to 3 months and 12 months after treatment was recorded. The mean vessels percentage area, junctions density, lacunarity, and fractal dimension were significantly correlated with the change of BCVA from baseline to month 3 (P = 0.003, 0.046, 0.007, and 0.005 respectively). FD and vessels percentage area were correlated with the change of BCVA from baseline to month 12 (P = 0.023 and 0.023 respectively). The findings suggest that baseline characteristics of choroidal neovascular complexes may serve as predictors for BCVA changes following treatment with aflibercept in nAMD patients.