bluuebunny/crossref_metadata_2025_split huggingface dataset:
Serum copper assessment in patients with polycystic ovary syndrome and tubal infertility: A retrospective 5‐year study
Authors: Liu Yanping , Zhang Wei , Liu Zhenxing , Zheng Aiyan , Liang Baoquan , Li Hong , Meng Qingxia 
Published: June 2024

AbstractThe association between serum copper and polycystic ovary syndrome (PCOS) lacks definitive conclusions, and the intricate interactions with in vitro fertilization (IVF) cycle characteristics in infertility remain insufficiently explored. This retrospective study included 560 patients with tubal infertility (no‐PCOS) and 266 patients with PCOS undergoing IVF at the Affiliated Suzhou Hospital of Nanjing Medical University from January 2018 to December 2022. Patients' basic characteristics, hormonal and metabolic parameters, essential trace elements, and IVF cycle characteristics were measured and analyzed. The results revealed a significantly elevated serum copper level in the PCOS group compared to the control group [17.27 (15.54, 19.67) vs 15.4 (13.87, 17.35), μmol/L; p < .001]. Spearman correlation analyses revealed a significant positive correlation between serum copper concentration and body mass index (BMI), fasting glucose (FG), triglyceride (TG), total cholesterol (TC), and low‐density lipoprotein (LDL) in the no‐PCOS group. Additionally, a notable negative correlation with high‐density lipoprotein (HDL) was observed (r = −.184, p < .001). Within the PCOS group, serum copper concentration correlated significantly with BMI (r = .198, p = .004) and TG (r = .214, p = .002). The linear trend analysis indicated no significant relationship between serum copper concentration and ovarian response as well as preimplantation outcomes in both groups after adjusting for confounding factors. Our study provided evidence of elevated serum copper concentration in PCOS patients, closely associated with lipid metabolism but showing no correlation with IVF outcomes. These findings provide valuable real‐world data, enriching our nuanced understanding of the role of copper in female fertility.
Prodromal or mild Alzheimer's disease: Influence of neuropsychiatric symptoms and premordid personality on caregivers' burden
Authors: Dorey J. M. , Pongan E. , Padovan C. , Chaillet A. , Herrmann M. , Krolak‐Salmon P. , Rouch I. 
Published: June 2024

AbstractObjectiveIn Alzheimer's disease (AD), the burden on caregivers is influenced by various factors, including the stage of disease progression and neuropsychiatric symptoms (NPS). To date, there has been limited research examining how patient's premorbid personality could affect this burden. The objective of this study was to investigate the impact of both premorbid personality and NPS in individuals with prodromal to mild AD on their caregivers' burden.MethodOne hundred eighty participants with prodromal or mild AD drown from the PACO (in French: Personnalité Alzheimer COmportement) cohort were included. Personality was assessed by the Revised NEO Personality Inventory (NEO‐PI‐R). Neuropsychiatric symptoms were measured with the short version of the Neuropsychiatric Inventory (NPI‐Q), and caregiver burden was evaluated with the Zarit burden scale. Relationships between personality, Neuro‐Psychiatric Inventory (NPI) scores, and caregiver burden were determined using multivariate linear regressions controlled for age, sex, educational level, and Mini Mental State Examination.ResultsThe total NPI score was related to increased burden (beta = 0.45; p < 0.001). High level of neuroticism (beta = 0.254; p = 0.003) et low level of conscientiousness (beta = ‐ 0.233; p = 0.005) were associated higher burden. Extraversion (beta = −0.185; p = 0.027) and conscientiousness (beta = −0.35; p = 0.006) were negatively associated with burden. In contrast, neuroticism, openness and agreeableness were not correlated with burden. When adjusted on total NPI score, the relationship between extraversion and conscientiousness didn't persist.ConclusionOur results suggest that premorbid personality of patients with prodromal to mild Alzheimer influence caregivers's burden, with a protective effect of a high level of extraversion and conscientiousness.
Progress in the environmental risk assessment of plant protection products in Brazil: An overview of aquatic organism proposals
Authors: Cione Ana Paola , Santos Gustavo Souza , Casallanovo Fábio 
Published: June 2024

Abstract
Since 2019, the Brazilian Institute of Environment and Renewable Natural Resources (IBAMA) has actively developed pesticide environmental risk assessment (ERA) frameworks adapted to Brazil's specific ecological contexts. This endeavor, supported by funding from the Brazilian Ministry of Justice and in partnership with academic institutions, has led to a concerted effort to establish ERA protocols for various taxa, including birds and mammals, soil organisms, aquatic organisms, and reptiles and amphibians. The outcomes of this initiative were conveyed in two workshops held in February and November 2023, during which the agency communicated its findings to the technical-regulatory community. This article represents one of two articles that provide more detailed insights into the ERA propositions for all taxa. In this article, we summarize the proposals for aquatic organisms presented and discussed during the workshops, which can be used as an informational source by the technical-regulatory community. Integr Environ Assess Manag 2024;20:1787–1792. © 2024 The Author(s). Integrated Environmental Assessment and Management published by Wiley Periodicals LLC on behalf of Society of Environmental Toxicology & Chemistry (SETAC).
Key Points
This brief communication summarizes the proposals for pesticide environmental risk assessment for aquatic organisms presented during a two-day workshop held by the Brazilian environmental agency (Brazilian Institute of Environment and Renewable Natural Resources) in November 2023.
Supramolecular Approaches to the Detoxification of Nerve Agents
Authors: Kubik Stefan 
Published: June 2024

AbstractA promising, but not yet practiced, approach to the treatment of neurotoxic organophosphate poisoning is the administration of a scavenger that rapidly deactivates the nerve agent before it can exert its toxic effects. The detoxification rates required for successful use of this therapy can currently only be achieved with enzymes, but synthetic scavengers, whose mode of action is based on key concepts of supramolecular chemistry, are an attractive alternative. Considerable progress has recently been made in the development of such scavengers, and compounds from several receptor classes are now available that not only bind nerve agents but also degrade them at promising rates. This review provides an overview of the field and highlights recent developments.
Synthesis, biological evaluation, and computational studies of thiazolyl hydrazone derivatives as triple mutant allosteric EGFR inhibitors
Authors: Shinde Sonali S. , Sarkate Aniket P. , Rathod Sanket S. , Kilbile Jaydeo T. , Chaudhari Somdatta Y. , Yadala Rajesh , Pawar Smita C. , Wakte Pravin S. 
Published: June 2024

AbstractHerein, new thiazole‐2‐yl‐based hydrazone derivatives were synthesized and assessed for in vitro anticancer activity against wild type A549, MCF7, DU145, and mutant H1975 cancer cell lines by 3‐(4,5‐dimethylthiazol‐2‐yl)‐2,5‐diphenyltetrazolium bromide (MTT) assay. Among all, 4‐(4‐Chlorophenyl)‐2‐(2‐((4‐methylthiazol‐5‐yl)methylene)hydrazineyl)thiazole (4b) elicited prominent anticancer activity against wild‐type epidermal growth factor receptor (WT‐EGFR) MCF7 cancer cell line with an IC50 value of 9.57 ± 1.80 μM, whereas 4‐Methyl‐5‐((2‐(4‐(4‐nitrophenyl)thiazol‐2‐yl)hydrazineylidene)methyl)thiazole (4c) showed appreciable activity with an IC50 value of 11 ± 0.7 μM against the mutated EGFR H1975 lung cancer cells. Doxorubicin and Osimertinib were used as the standard drugs for comparison of activity. Compound (4b) significantly increased early apoptosis (30.2%) and late apoptosis (7.6%) at a 5 μM concentration in comparison with the control (early apoptosis 2.5%, late apoptosis 1.2%). The molecular docking study was performed against mutant EGFR (T790M/C797S) (PDB: 5D41) enzyme to gain information about interactions of synthesized molecules with binding pockets. Moreover, ADME study and molecular dynamic simulation studies were accomplished to gain insight into drug‐likeness and conformational stability, respectively. The findings demonstrate a promising alignment between the observed anticancer effects and computational analyses.
Association between preoperative phase angle and all‐cause mortality after cardiovascular surgery: A retrospective cohort study
Authors: Shibata Kenichi , Kameshima Masataka , Adachi Takuji , Kito Hisako , Tanaka Chikako , Sano Taisei , Tanaka Mizuki , Suzuki Yoriyasu , Tamaki Mototsugu , Kitamura Hideki 
Published: June 2024

AbstractBackgroundThe importance of preoperative physical function assessment for post‐operative intervention has been reported in older patients undergoing cardiovascular surgery. Phase angle (PhA), measured using bioelectrical impedance analysis, is an indicator of cellular health and integrity and is reported as a prognostic factor in several chronic diseases; however, its association with the long‐term prognosis of cardiovascular surgery remains unclear. This study aimed to investigate the prognostic value of PhA for long‐term mortality in patients undergoing cardiovascular surgery.MethodsThis retrospective cohort study included consecutive patients who underwent elective cardiovascular surgery between October 2016 and March 2021 at Nagoya Heart Center, Japan. PhA was assessed using bioelectrical impedance analysis before surgery, and physical function measures (gait speed, grip strength and short physical performance battery [SPPB]) were measured synchronously. The association between PhA and all‐cause mortality after discharge was assessed using Kaplan–Meier and multivariate Cox regression analyses. The incremental prognostic value of PhA was compared with other physical function measures using net reclassification improvement (NRI) and integrated discrimination improvement (IDI).ResultsA total of 858 patients were included in the present analysis (mean age = 68.4 ± 11.9 years, 67.6% male). PhA positively correlated with body mass index (ρ = 0.38, P < 0.001), skeletal muscle mass index (ρ = 0.58, P < 0.001), usual gait speed (ρ = 0.44, P < 0.001), grip strength (ρ = 0.73, P < 0.001) and SPPB (ρ = 0.51, P < 0.001). The mean follow‐up period, within which 44 (4.7%) died, was 908.9 ± 499.9 days for the entire cohort. Kaplan–Meier survival curves based on the PhA tertiles showed that higher PhA was associated with better survival (log‐rank test, P < 0.001). The Cox regression analysis showed the independent association of PhA with mortality risk (hazard ratio: 0.91 per 0.1° increment; 95% confidence interval [CI]: 0.87–0.95; P < 0.001). The NRI and IDI showed significant improvements in predicting mortality after adding PhA to the clinical model consisting of age, sex and cardiac and renal function (NRI: 0.426, 95% CI: 0.124–0.729, P = 0.006; IDI: 0.037, 95% CI: 0.012–0.062, P = 0.003). The predictive model consisting of the clinical model and PhA was superior to the model consisting of the clinical model and each of the other physical function indicators (P < 0.05).ConclusionsPhA correlated with physical function and independently predicted long‐term mortality after cardiovascular surgery. The additive prognostic value of PhA compared with the other physical function measures suggests the clinical usefulness of preoperative PhA for risk stratification in planning post‐operative treatment and rehabilitation.
The Na+/Ca2+ exchanger NCX3 mediates Ca2+ entry into matrix vesicles to facilitate initial steps of mineralization in osteoblasts
Authors: Sheikh Irshad A. , Midura‐Kiela Monica T. , Herchuelz André , Sokolow Sophie , Kiela Pawel R. , Ghishan Fayez K. 
Published: June 2024

AbstractMatrix vesicles (MVs) provide the initial site for amorphous hydroxyapatite (HA) formation within mineralizing osteoblasts. Although Na+/Ca2+ exchanger isoform‐3 (NCX3, SLC8A3) was presumed to function as major Ca2+ transporter responsible for Ca2+ extrusion out of osteoblast into the calcifying bone matrix, its presence and functional role in MVs have not been investigated. In this study, we investigated the involvement of NCX3 in MV‐mediated mineralization process and its impact on bone formation. Using differentiated MC3T3‐E1 cells, we demonstrated that NCX3 knockout in these cells resulted in a significant reduction of Ca2+ deposition due to reduced Ca2+ entry within the MVs, leading to impaired mineralization. Consequently, the capacity of MVs to promote extracellular HA formation was diminished. Moreover, primary osteoblast isolated from NCX3 deficient mice (NCX3−/−) exhibits reduced mineralization efficacy without any effect on osteoclast activity. To validate this in vitro finding, μCT analysis revealed a substantial decrease in trabecular bone mineral density in both genders of NCX3−/− mice, thus supporting the critical role of NCX3 in facilitating Ca2+ uptake into the MVs to initiate osteoblast‐mediated mineralization. NCX3 expression was also found to be the target of downregulation by inflammatory mediators in vitro and in vivo. This newfound understanding of NCX3's functional role in MVs opens new avenues for therapeutic interventions aimed at enhancing bone mineralization and treating mineralization‐related disorders.
Multiple myeloma in Latin America: A systematic review
Authors: de Moraes Hungria Vania Tietsche , Peña Camila , Gómez‐Almaguer David , Martínez‐Cordero Humberto , Schütz Natalia Paola , Blunk Vivian 
Published: June 2024

AbstractThe incidence of multiple myeloma (MM) has surged globally, particularly in Latin American countries, and is attributable to an aging population and increased life expectancy. This systematic review analyzes the epidemiology, patient characteristics, and treatment outcomes for MM in selected Latin American countries: Brazil, Mexico, Colombia, Argentina, Chile, Peru, and Uruguay. PubMed and the Latin American and Caribbean Health Sciences Literature (LILACS), conference abstracts (between June 2019 and June 2022), and GLOBOCAN registry (January 2010 to June 2022) were electronically searched. Qualitative analysis employed the Joanna Briggs Institute's critical appraisal tool. Among the 586 screened articles, 26 met the inclusion criteria. The participants’ median age ranged from 54 to 67 years. GLOBOCAN data revealed that for MM, Brazil and Uruguay had the highest and lowest incidence, 5‐year prevalence, and mortality, respectively. Immunoglobulin G was the most common subtype detected. Stage III was frequently diagnosed. Though many approved drugs are available and bispecific antibodies hold promise as a future therapy, limited access, especially for CAR‐T cell‐based therapy remains a concern. The incidence of MM is increasing in Latin America. Resource constraints and costs hinder access to novel drugs and regimens. Understanding disease patterns and patient characteristics is vital to improve MM management in these countries.
Evolution of an Overlapped Bandgap and Topological Flat Bands in a Higher‐Order Valley Photonic Insulator Based on Dendritic Structure
Authors: Li Meize , Liu Yahong , Tao Liyun , Ma Shaojie , Dong Yibao , Li Zhenfei , Du Lianlian , Guo Yao , Song Kun , Zhao Xiaopeng 
Published: June 2024

AbstractRobust edge states and corner states in photonic topological insulators provide effective ways to manipulate the propagation of electromagnetic waves. Bandgaps of the previously reported photonic topological insulators are independent of each other. In this paper, a higher‐order valley photonic insulator composed of arrays of dendritic structure is designed. The band structure shows an overlapped bandgap is observed, and the overlapped bandgap divides the band structure into three bandgaps. The evolution of the overlapped bandgap is investigated by changing the geometric parameters and increasing the fractal to break the C3v symmetry drastically. Besides, it is notable that the band structure of the proposed valley photonic insulator is flat bands. It is demonstrated that undistorted transmission can be observed as a plane electromagnetic wave transmits through the proposed valley photonic insulator. The interface consisting of two valley photonic structures with distinct topological nontrivial phases is constructed. Edge states and corner states with strong energy localization are obtained in multi‐band frequencies. Remarkably, two triangular structures with different Wannier center configurations both have corner states in the same bandgap, which does not obey the valley selectivity. The phenomenon is caused by the weak valley locking property due to the overlapped bandgap. The proposed valley photonic insulators are expected to benefit applications in optical devices such as topological lasers.
Higher‐Order Topological Corner States in a Specially Distorted Photonic Kagome Lattice
Authors: Zhong Qi , Liang Yongsheng , Xia Shiqi , Gao Shenyi , Song Limin , Hou Fucheng , Tang Liqin , Song Daohong , Chen Zhigang 
Published: June 2024

AbstractKagome lattices have garnered significant interest over the decades due to their rich physics and implications for exotic superconductors and topological materials. In particular, the so‐called “breathing Kagome lattice” (BKL) is often used as a prototypical model to understand higher‐order topological insulators. Here it is demonstrated that higher‐order corner states exist in a specially distorted Kagome lattice, resembling the “Inverse Hexagram” lattice distortion originally introduced in the study of charge density waves in Kagome metals. Importantly, it is found that such an Inverse Hexagram‐like Kagome lattice with C6 rotational symmetry hosts two types of in‐gap corner states, in contrast to a flat‐cutting BKL of C3 symmetry that supports only one type of corner state under the tight‐binding condition. It is shown that the nontrivial corner states exhibit a fractional corner anomaly, revealing the feature of higher‐order topology. Using laser‐written waveguide lattices as a photonic platform, these two types of corner states are experimentally observed, along with a direct comparison with the corner excitation at their trivial counterparts. Experimental observations are further corroborated by numerical simulations and stability analysis under random perturbation. These results may prove relevant and applicable to similar phenomena in other Kagome platforms beyond photonics.
Blue‐Light‐Excitable Broadband Ca3Ga2Ge3O12:Cr3+,Ni2+ Phosphor for the Applications in NIR‐II Window
Authors: Zhao Fangyi , Shao Yuhe , Liu Quanlin , Zhong Jiasong 
Published: June 2024

AbstractNear‐infrared (NIR) phosphor‐converted light‐emitting diode (pc‐LED) light sources in the second NIR window (NIR‐II, 1000–1700 nm) have sparked great interest for their emerging applications in non‐destructive detection and medical diagnostics fields. However, the development of efficient NIR‐II phosphors that can be excited by commercial blue LED chips remains a significant challenge, and thus impeding the applications of NIR pc‐LED. Herein, a blue‐light‐excitable broadband NIR‐II luminescence of Ni2+ is achieved upon incorporating Cr3+ and Ni2+ into the Ca3Ga2Ge3O12 (CGGO) host simultaneously. Through the energy transfer from Cr3+ to Ni2+, CGGO:Cr3+,Ni2+ phosphor presents the improved NIR‐II emission peaking at 1470 nm under 460 nm blue light excitation. The internal/external quantum efficiency values are significantly improved from 13.8%/3.3% to 24.6%/13.3% along with the enhanced luminescence thermal stability. Finally, a NIR pc‐LED is fabricated by combining CGGO:Cr3+,Ni2+ phosphor with 450 nm blue chip, and its potential applications in non‐destructive examination and biomedical imaging fields have been demonstrated. The strategy of Cr3+ and Ni2+ co‐doping solves the problem that Ni2+ luminescence cannot be effectively excited by blue light and provides the design insights to exploit more ultra‐broadband NIR pc‐LEDs based on blue LED chips.
Quantifying intergranular corrosion susceptibility in AA2098‐T351 weldments through friction stir welding
Authors: Milagre Mariana X. , Donatus Uyime , Mogili Naga V. , Machado Caruline S. C. , Araujo João Victor. S. , Silva Rejane Maria P. , Antunes Renato A. , Farooq Sajid , Costa Isolda 
Published: June 2024

AbstractIn this study, the intergranular corrosion (IGC) susceptibility of AA2098‐T351 welds, fabricated through friction stir welding (FSW), was systematically evaluated. The evaluation employed American Society for Testing and Materials (ASTM) G110‐92 practice and electrochemical impedance measurements, with comparative analyses against unwelded alloys (BS). The key findings depicted that FSW‐induced microstructure changes significantly influenced IGC susceptibility across different zones. Zones affected by FSW presented distinct susceptibilities compared with the base metal (BM). The ASTM G110‐92 test effectively differentiated the heat‐affected zone (HAZ) into segments with changing corrosion resistances based on welding temperature gradients. Cross‐sectional analyses using scanning electron microscopy (SEM) techniques correlated corrosion characteristics with microstructural features identified by transmission electron microscopy (TEM). Overall, FSW‐induced microstructural alterations emerged as a predominant factor influencing the varying susceptibilities of different zones to IGC, and electrochemical impedance measurements (EIS) validated the findings from ASTM G110‐92 practice.
Atmospheric corrosion of AISI‐1020 carbon steel in a very aggressive coastal zone of Havana, Cuba. Determination of corrosivity category using three ways of assessment
Authors: Castañeda Abel , Valdés Cecilia , Corvo Francisco , Pech Ildefonso , Marrero Rigoberto 
Published: June 2024

AbstractThe Cuban coastal line is reported to be one of the most aggressive in the world. Three ways to estimate corrosivity category of the atmosphere were considered. The influence of meteorological parameters on chloride deposition rate in saline solution form was considered as a first way. Corrosion rate calculated by dose response function is considered a second way. It was confirmed that atmospheric corrosion of AISI‐1020 carbon steel is influenced by and in salt solution form. A critical level from which could increase was estimated. The presence of typical crystalline phases of carbon steel confirmed that formation mechanism led to cracking of the corrosion products layer. It justified the increase of rcorr as a function of time until reaching a very high (C5) corrosivity category as the third assessment way. was predicted up to 20 years of exposure. A correspondence between the three assessment ways existed.