bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of acute high-intensity interval exercise on a mouse model of doxorubicin-induced cardiotoxicity: a pilot study
Authors: Legault Elise P. , Ribeiro Paula A. B. , Petrenyov Daniil R. , Drumeva Gergana O. , Leduc Charles , Khullar Sharmila , DaSilva Jean N. , Comtois Alain Steve , Tournoux François B. 
Published: April 2024

AbstractBackgroundIt is unknown whether high-intensity interval exercise (HIIE) may potentiate or attenuate the cardiotoxic effect of chemotherapy agents such as doxorubicin (DOX) when performed shortly after treatment. The study aimed to investigate the effect of acute HIIE on cardiac function and structure performed either 1, 2 or 3 days after DOX injection in an animal model.MethodsFemale C57bl/6 mice (n = 28), 70 days old, received a bolus 20 mg/kg intravenous tail vein DOX injection. Three exercise groups performed 1 HIIE session (16 sets of 1 min at 85–90% of peak running speed) at 1 (n = 7), 2 (n = 7), and 3 days (n = 8) following the DOX injection. A sedentary (SED) group of mice (n = 6) did not exercise. Animals underwent echocardiography under light anesthesia (isoflurane 0.5-1%) before and 7 days after the DOX injection. Animals were sacrificed on day 9 and hearts were collected for morphometric and histological analysis.ResultsAnimals exercising on day 3 had the smallest pre-post reduction in left ventricular fractional shortening (LVFS) (MΔ= -1.7 ± 3.3;p = 0.406) and the SED group had the largest reduction (MΔ=-6.8 ± 7.5;p = 0.009). After reclassification of animals according to their exercise compliance (performing > 8/16 of high-intensity bouts), LVFS in compliant mice was unchanged over time (LVFS MΔ= -1.3 ± 5.6;p = 0.396) while non-compliant animals had a LVFS reduction similar to sedentary animals. There were no significant differences in myocardial histology between groups.ConclusionsIn this pilot murine study, one single HIIE session did not exacerbate acute doxorubicin-induced cardiotoxicity. The timing of the HIIE session following DOX injection and the level of compliance to exercise could influence the negative impact of DOX on cardiac function.
Cognitive performance of post-covid patients in mild, moderate, and severe clinical situations
Authors: de Pádua Serafim Antonio , Saffi Fabiana , Soares Amanda Rafaella A. , Morita Alessandra Mara , Assed Mariana Medeiros , de Toledo Sandro , Rocca Cristiana C. A. , Durães Ricardo S. S. 
Published: April 2024

Abstract
Background
Studying individuals with varying symptoms, from mild to severe, can provide valuable insights into the spectrum of cognitive outcomes after COVID-19. We investigated the cognitive performance of adults who recovered from the novel coronavirus disease (COVID-19) without prior cognitive complaints, considering mild (not hospitalized), moderate (ward), and severe (intensive care unit) symptoms.

Methods
This cross-sectional study included 302 patients who recovered from COVID-19 (mild, n = 102; moderate, n = 102; severe, n = 98). We assessed intellectual quotient (IQ), attention, memory, processing speed, visual-constructive ability, as well as symptoms of depression, anxiety, and stress, at least eighteen months after infection. The mean length of hospitalization was Mdays=8.2 (SD = 3.9) and Mdays=14.4 (SD = 8.2) in the moderate and severe groups, respectively.

Results
Cognitive difficulties were present in all three groups: mild (n = 12, 11.7%), moderate (n = 40, 39.2%), and severe (n = 48, 48.9%). Using Multinomial Logistic Regression and considering the odds ratio, our results indicated that a one-point increase in sustained attention, visual memory, and working memory might decrease the odds of being categorized in the severe group by 20%, 24%, and 77%, respectively, compared to the mild group.

Conclusions
Our findings provide empirical evidence regarding the long-term cognitive effects of COVID-19, particularly in individuals experiencing severe manifestations of the disease. We also highlighted the need for a comprehensive, multidimensional approach in rehabilitation programs to address the enduring cognitive impacts of COVID-19.
Medication reconciliation by pharmacists for pre-admission patients improves patient safety
Authors: Yamada Yunami , Kobayashi Ryo , Yamamoto Taishi , Fujii Hironori , Iihara Hirotoshi , Hiroko Kato-Hayashi , Nishida Shohei , Hoshino Ryo , Niwa Takashi , Kumada Keisuke , Shimizu Masahito , Suzuki Akio 
Published: April 2024

Abstract
Background
Medication errors related to the pre-admission medication history obtained on admission are a major cause of medication error during hospitalization. Medication reconciliation (MR) improves patient safety through the detection of inadvertent medication discrepancies at transitions of care. The aim of this study was to evaluate the effect of MR by pharmacists for patients prior to hospital admission on the incidence of medication errors in the early post-admission period.

Patients and methods
Patients admitted to the orthopedic ward for surgery between April 2012 and March 2020 were included. Pharmacist-led MR for pre-admission patients was started on April 1, 2017. The incidence of medication errors related to pre-admission medications that occurred during hospitalization were compared between the pre- and post-initiation of pharmacist-led MR (pre-initiation: April 1, 2012 to March 31, 2015, post-initiation: April 1, 2017 to March 31, 2020).

Result
In the post-initiation group, 94.2% (1245/1321) of patients who were taking medications on admission had a pharmacist-led MR before admission. The proportion of patients whose physicians ordered the prescription of their pre-admission medications at the time before hospitalization to continue from admission was significantly higher in the post-initiation group than in the pre-initiation group (47.4% vs. 1.0%, p < 0.001). The incidence of medication errors related to pre-admission medications during hospitalization was significantly lower in the post-initiation group than in the pre-initiation group (1.83% vs. 0.85%, p = 0.025). Pharmacist-led MR prior to admission was a significant protective factor against incidents related to pre-admission medication (odds ratio (OR), 0.3810; 95% confidence interval (CI); 0.156–0.9320, p = 0.035).

Conclusion
Pharmacist-led MR for patients prior to hospital admission led to a reduction in medication errors related to pre-admission medications during hospitalization. Patient safety during hospitalization can be improved by accurate medication histories provided early by pharmacists.
Factors affecting E-HRM practices in Greek shipping management companies: the role of organizational culture, cultural intelligence, and innovation
Authors: Theotokas Ioannis N. , Lagoudis Ioannis N. , Syntychaki Athina , Prosilias John 
Published: April 2024

AbstractHRM is forced to adapt and reinvent its practices towards more innovative and creative frameworks and models, due to the impetus technological developments in the modern business environment. The same applies to the elements of the organizational culture and corporate structure, which are decisive for the success of such initiatives. To undergo the shift to digital transformation, there is a need for human resource development professionals to invest in advanced competencies and capabilities. The scope of this paper is to examine the concept of digital innovation and HRM digitalization in the shipping industry and their relationship with corporate culture, intelligence, and leadership. Data were collected via a survey conducted in Greek shipping companies, and personal interviews with maritime professionals. Findings show that organizational culture and cultural intelligence are significant factors for digital innovation. Digital culture and digital leadership are proving to be important components in achieving this, whereas organizational cultural intelligence has a major impact on e-HRM. The present research contributes at both academic and policy level. In the former case is assists in bridging the gap in the maritime literature by examining digital innovation and e-HRM practices in the shipping industry along with the required skills for their development or enhancement. In the latter case the paper assists in the documentation of challenges maritime companies face in relation to digitalization practices and how policy makers can assist in their adoption.
To be or not to B27 positive: implications for the phenotypes of axial spondyloarthritis outcomes. Data from a large multiracial cohort from the Brazilian Registry of Spondyloarthritis
Authors: Resende Gustavo Gomes , Saad Carla Goncalves Schahin , Marques Claudia Diniz Lopes , Ribeiro Sandra Lúcia Euzébio , de Oliveira Gavi Maria Bernadete Renoldi , Yazbek Michel Alexandre , de Oliveira Marinho Adriana , de Cássia Menin Rita , Ochtrop Manuella Lima Gomes , Soares Andressa Miozzo , Cavalcanti Nara Gualberto , Carneiro Jamille Nascimento , Werner de Castro Glaucio Ricardo , Fernandes José Mauro Carneiro , da Cruz Ribeiro E Souza Elziane , de Menezes Alvarenga Corina Quental , de Abreu Vieira Rejane Maria Rodrigues , Machado Natalia Pereira , Ximenes Antônio Carlos , Gazzeta Morgana Ohira , de Albuquerque Cleandro Pires , Skare Thelma Larocca , Waldemar Keiserman Mauro , Kohem Charles Lubianca , Benacon Gabriel Sarkis , Rocha Vítor Florêncio Santos , da Cruz Lage Ricardo , Malheiro Olivio Brito , Golebiovski Rywka Tenenbaum Medeiros , Oliveira Thauana Luiza , Duque Ruben Horst , Londe Ana Carolina , de Medeiros Pinheiro Marcelo , Sampaio-Barros Percival Degrava 
Published: April 2024

Abstract
Background
There is a remarkable variability in the frequency of HLA-B27 positivity in patients with spondyloarthritis (SpA), which may be associated with different clinical presentations worldwide. However, there is a lack of data considering ethnicity and sex on the evaluation of the main clinical and prognostic outcomes in mixed-race populations. The aim of this study was to evaluate the frequency of HLA-B27 and its correlation with disease parameters in a large population of patients from the Brazilian Registry of Spondyloarthritis (RBE).

Methods
The RBE is a multicenter, observational, prospective cohort that enrolled patients with SpA from 46 centers representing all five geographic regions of Brazil. The inclusion criteria were as follow: (1) diagnosis of axSpA by an expert rheumatologist; (2) age ≥18 years; (3) classification according to ASAS axial. The following data were collected via a standardized protocol: demographic data, disease parameters and treatment historical.

Results
A total of 1096 patients were included, with 73.4% HLA-B27 positivity and a mean age of 44.4 (±13.2) years. Positive HLA-B27 was significantly associated with male sex, earlier age at disease onset and diagnosis, uveitis, and family history of SpA. Conversely, negative HLA-B27 was associated with psoriasis, higher peripheral involvement and disease activity, worse quality of life and mobility.

Conclusions
Our data showed that HLA-B27 positivity was associated with a classic axSpA pattern quite similar to that of Caucasian axSpA patients around the world. Furthermore, its absence was associated with peripheral manifestations and worse outcomes, suggesting a relevant phenotypic difference in a highly miscegenated population.
ADGRG1-related polymicrogyria syndrome: report on a large consanguineous family with a novel variant and review
Authors: El Khatib Dalida , Hojeij Moussa , Sabbagh Sandra , Mehawej Cybel , Chouery Eliane , Ryu Seung Woo , Kim JiHye , Mégarbané Andre 
Published: April 2024

Abstract
Background
Polymicrogyria is a spectrum of complex cortical malformations encompassing multiple subtypes. Of these, bilateral frontoparietal polymicrogyria (BFPP) has been associated with pathogenic variants in the ADGRG1 gene, formerly known as GPR56. BFPP is characterized by cognitive impairment, motor delay, seizures, oculomotor findings, cerebellar, pyramidal signs, and brain malformations that consist of abnormal changes in the cortex, white matter, brainstem, and cerebellum.

Case presentation
A large consanguineous Syrian family with five affected individuals exhibiting features of BFPP, is included in this study. These patients presented with cognitive impairment, psychomotor delay, epileptic episodes, cerebellar signs, oculomotor findings, and brain malformations. Through whole exome sequencing, a novel homozygous pathogenic variant in the ADGRG1 gene (NM_201525.4: c.308T > C; p.Leu103Pro) was identified.

Conclusion
Here, we report a thorough literature review of cases with BFPP, and we discuss the importance of genetic counseling in families with genetic disorders, especially in underdeveloped countries.
The effect of cigarette and e-cigarette smoke on dental pulp stem cells proliferation capacity and differentiation [in vitro study]
Authors: Riad Dalia , Nour Eldin Amani , Hamouda Mai Abdelhalim 
Published: April 2024

Abstract
Background
Mesenchymal stem cells (MSCs) have long been known for their ability to regenerate tissue. Cigarette smoking is one environmental risk factor that may impair the performance of MSCs. Electronic cigarettes have recently become a popular and widely accepted alternative to tobacco cigarettes due to their safety. The present study aims to analyze how smoke extracts of cigarette tobacco and electronic cigarettes affect the capability of dental pulp stem cell (DPSCs) proliferation and osteogenic differentiation. In this study, DPSCs were isolated from healthy impacted third molars of non-smokers, and two smoke extracts were made from tobacco powder and electronic cigarettes. Half maximal inhibitory concentration (IC50) was calculated at two time intervals (14 and 21 days), and its effect on the proliferation and osteogenic differentiation of the DPSCs was assessed.

Results
The proliferation rate with the calculated IC50 of both smoke extracts was reduced compared to control cells. After 21 days of osteogenic induction, significantly fewer calcium deposits were visible among cells exposed to both smoke extracts. In addition, the expression of alkaline phosphatase and RANKL proteins was significantly reduced in differentiated DPSCs subjected to both smoke extracts.

Conclusions
DPSCs exposed to both smoke extracts showed decreased cell viability and osteogenic differentiation potentiality compared to control cells. Smoking in any form has a detrimental effect on the proliferation and regenerative capacity of MSCs.
The unconfined compressive strength estimation of rocks using a novel hybridization technique based on the regulated Gaussian processor
Authors: Huang Linhua , Li Song , Guo Enping 
Published: April 2024

AbstractThe unconfined compressive strength (UCS) of rocks is a crucial factor in geotechnical engineering, assuming a central role in various civil engineering undertakings, including tunnel construction, mining operations, and the design of foundations. The precision in forecasting UCS holds paramount importance in upholding the security and steadfastness of these endeavors. This article introduces a fresh methodology for UCS prognostication by amalgamating Gaussian process regression (GPR) with two pioneering optimization techniques: sand cat swarm optimization (SCSO) and the equilibrium slime mould algorithm (ESMA). Conventional techniques for UCS prediction frequently encounter obstacles like gradual convergence and the potential for becoming ensnared in local minima. In this investigation, GPR is the foundational predictive model due to its adeptness in managing nonlinear associations within the dataset. The fusion of GPR with cutting-edge optimizers is envisioned to elevate the precision and expeditiousness of UCS prognostications.An extensive collection of rock samples, each accompanied by UCS measurements, is harnessed to assess the suggested methodology. The efficacy of the GPSC and GPES models is juxtaposed with the conventional GPR technique. The findings reveal that incorporating SCSO and ESMA optimizers into GPR brings about a noteworthy enhancement in UCS prediction accuracy and expedites convergence. Notably, the GPSC models exhibit exceptional performance, evidenced by an exceptional R2 value of 0.995 and an impressively minimal RMSE value of 1.913. These findings emphasize the GPSC model’s potential as an exceedingly auspicious tool for experts in the realms of engineering and geology. It presents a sturdy and dependable method for UCS prediction, a resource of immense value in augmenting the security and efficiency of civil engineering endeavors.
Using Machine Learning to Predict Unplanned Hospital Utilization and Chemotherapy Management From Patient-Reported Outcome Measures
Authors: Wójcik Zuzanna , Dimitrova Vania , Warrington Lorraine , Velikova Galina , Absolom Kate 
Published: April 2024

PURPOSE Adverse effects of chemotherapy often require hospital admissions or treatment management. Identifying factors contributing to unplanned hospital utilization may improve health care quality and patients' well-being. This study aimed to assess if patient-reported outcome measures (PROMs) improve performance of machine learning (ML) models predicting hospital admissions, triage events (contacting helpline or attending hospital), and changes to chemotherapy. MATERIALS AND METHODS Clinical trial data were used and contained responses to three PROMs (European Organisation for Research and Treatment of Cancer Core Quality of Life Questionnaire [QLQ-C30], EuroQol Five-Dimensional Visual Analogue Scale [EQ-5D], and Functional Assessment of Cancer Therapy-General [FACT-G]) and clinical information on 508 participants undergoing chemotherapy. Six feature sets (with following variables: [1] all available; [2] clinical; [3] PROMs; [4] clinical and QLQ-C30; [5] clinical and EQ-5D; [6] clinical and FACT-G) were applied in six ML models (logistic regression [LR], decision tree, adaptive boosting, random forest [RF], support vector machines [SVMs], and neural network) to predict admissions, triage events, and chemotherapy changes. RESULTS The comprehensive analysis of predictive performances of the six ML models for each feature set in three different methods for handling class imbalance indicated that PROMs improved predictions of all outcomes. RF and SVMs had the highest performance for predicting admissions and changes to chemotherapy in balanced data sets, and LR in imbalanced data set. Balancing data led to the best performance compared with imbalanced data set or data set with balanced train set only. CONCLUSION These results endorsed the view that ML can be applied on PROM data to predict hospital utilization and chemotherapy management. If further explored, this study may contribute to health care planning and treatment personalization. Rigorous comparison of model performance affected by different imbalanced data handling methods shows best practice in ML research.
Cell coupling compensates for changes in single-cell Her6 dynamics and provides phenotypic robustness
Authors: Doostdar Parnian , Hawley Joshua , Chopra Kunal , Marinopoulou Elli , Lea Robert , Arashvand Kiana , Biga Veronica , Papalopulu Nancy , Soto Ximena 
Published: April 2024

ABSTRACT
This paper investigates the effect of altering the protein expression dynamics of the bHLH transcription factor Her6 at the single-cell level in the embryonic zebrafish telencephalon. Using a homozygote endogenous Her6:Venus reporter and 4D single-cell tracking, we show that Her6 oscillates in neural telencephalic progenitors and that the fusion of protein destabilisation (PEST) domain alters its expression dynamics, causing most cells to downregulate Her6 prematurely. However, counterintuitively, oscillatory cells increase, with some expressing Her6 at high levels, resulting in increased heterogeneity of Her6 expression in the population. These tissue-level changes appear to be an emergent property of coupling between single-cells, as revealed by experimentally disrupting Notch signalling and by computationally modelling alterations in Her6 protein stability. Despite the profound differences in the single-cell Her6 dynamics, the size of the telencephalon is only transiently altered and differentiation markers do not exhibit significant differences early on; however, a small increase is observed at later developmental stages. Our study suggests that cell coupling provides a compensation strategy, whereby an almost normal phenotype is maintained even though single-cell gene expression dynamics are abnormal, granting phenotypic robustness.
GPR124 regulates murine brain embryonic angiogenesis and BBB formation by an intracellular domain-independent mechanism
Authors: Yuki Kanako , Vallon Mario , Ding Jie , Rada Cara C. , Tang Alan T. , Vilches-Moure José G. , McCormick Aaron K. , Henao Echeverri Maria F. , Alwahabi Samira , Braunger Barbara M. , Ergün Süleyman , Kahn Mark L. , Kuo Calvin J. 
Published: April 2024

ABSTRACT
The GPR124/RECK/WNT7 pathway is an essential regulator of CNS angiogenesis and blood-brain barrier (BBB) function. GPR124, a brain endothelial adhesion seven-pass transmembrane protein, associates with RECK, which binds and stabilizes newly synthesized WNT7 that is transferred to frizzled (FZD) to initiate canonical β-catenin signaling. GPR124 remains enigmatic: although its extracellular domain (ECD) is essential, the poorly conserved intracellular domain (ICD) appears to be variably required in mammals versus zebrafish, potentially via adaptor protein bridging of GPR124 and FZD ICDs. GPR124 ICD deletion impairs zebrafish angiogenesis, but paradoxically retains WNT7 signaling upon mammalian transfection. We thus investigated GPR124 ICD function using the mouse deletion mutant Gpr124ΔC. Despite inefficiently expressed GPR124ΔC protein, Gpr124ΔC/ΔC mice could be born with normal cerebral cortex angiogenesis, in comparison with Gpr124−/− embryonic lethality, forebrain avascularity and hemorrhage. Gpr124ΔC/ΔC vascular phenotypes were restricted to sporadic ganglionic eminence angiogenic defects, attributable to impaired GPR124ΔC protein expression. Furthermore, Gpr124ΔC and the recombinant GPR124 ECD rescued WNT7 signaling in culture upon brain endothelial Gpr124 knockdown. Thus, in mice, GPR124-regulated CNS forebrain angiogenesis and BBB function are exerted by ICD-independent functionality, extending the signaling mechanisms used by adhesion seven-pass transmembrane receptors.