bluuebunny/crossref_metadata_2025_split huggingface dataset:
ChemInform Abstract: The “Azirine/Oxazolone Method” in Peptaibol Synthesis: Preparation of a Derivative of Trichotoxin A‐50 (G)
Authors: Altherr Werner , Linden Anthony , Heimgartner Heinz 
Published: June 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Natural Products and Their Biological Targets: Proteomic and Metabolomic Labeling Strategies
Authors: Boettcher Thomas , Pitscheider Maximilian , Sieber Stephan A. 
Published: June 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Carbonic Anhydrase IV Mediates the Fizz of Carbonated Beverages
Authors: Dunkel Andreas , Hofmann Thomas 
Published: June 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Microbial Siderophores
Authors: Budzikiewicz Herbert 
Published: June 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Resin Glycosides from the Morning Glory Family
Authors: Pereda‐Miranda Rogelio , Rosas‐Ramirez Daniel , Castaneda‐Gomez Jhon 
Published: June 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Mechanisms of RNA Degradation by the Eukaryotic Exosome
Authors: Tomecki Rafal , Drazkowska Karolina , Dziembowski Andrzej 
Published: June 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Exploitation of a Chain‐End‐Control Mechanism for the Synthesis of Alternating Copolymers
Authors: Carpentier Jean‐Francois 
Published: June 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Triggering Release of Encapsulated Cargo
Authors: Johnston Angus P. R. , Such Georgina K. , Caruso Frank 
Published: June 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Recent Mechanistic Insights in the Singlet Oxygen Ene Reaction
Authors: Alberti Mariza N. , Orfanopoulos Michael 
Published: June 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Analyse interagierender Partikel‐Zell‐Systeme mittels Durchflusszytometrie und mehrdimensionalen Populationsbilanzen
Authors: Rollié S. , Sundmacher K. 
Published: June 2010

AbstractZur Bestimmung der Clusterzusammensetzung und ihrer Dynamik in Heteroaggregationsprozessen hat sich die Durchflusszytometrie als wertvolles Messverfahren erwiesen. Sie ermöglicht die unabhängige Auflösung mehrdimensionaler Verteilungen durch eine zuverlässig automatisierte Einzelpartikelanalyse in bisher unerreichtetem Detaillierungsgrad. Bei Untersuchungen binärer und ternärer Partikelgemische lag der Fokus auf elektrostatischen (De‐)Stabilisierungseffekten, die durch die Auswahl geeigneter Partikelspezies und deren Mischungsverhältnis maßgeblich gesteuert werden können. Experimentelle Ergebnisse konnten mit mehrdimensionalen deterministischen Populationsbilanzen simuliert werden. Der physikalisch diskrete Eigenschaftsraum wurde adaptiv mit einer semi‐heuristischen Methode reduziert, so dass nur Eigenschaftskoordinaten mit hohen Partikelkonzentrationen im Modell berücksichtigt werden. Die verwendeten Aggregationskernel basieren auf kolloidchemischen Grundlagen, insbesondere der DLVO‐Theorie, und verknüpfen die Interaktionen auf der Einzelpartikelskala mit dem makroskopischen Verhalten gesamter Partikelpopulationen. Die an partikulären Systemen entwickelten Methoden wurden erfolgreich für eine systematische, modellgestützte Aufklärung präferentieller Aggregationsprozesse in einem ternären System aus Antikörpern und zwei humanen Tumorzelllinien (KARPAS‐299 und U‐937) eingesetzt. Trotz angenommener instantanter Aggregation bei Rezeptor‐Ligand‐Kollisionen, verursacht die geringe Rezeptorkonzentration einen ratenlimitierten Aggregationprozess (RLCA) durch die geringe Oberflächenkonzentration zellulärer Rezeptoren. Populationsbilanzsimulationen mit Kernels, die stark heterogene Oberflächenstukturen der aggregierenden Spezies berücksichtigen (patchy particles), bestätigen die experimentellen Befunde. Die zielgerichtete Verabreichung pharmazeutischer Wirkstoffe mittels Carrierpartikeln an spezifische Zellen unter Minimierung nachteiliger Beeinflussung übriger Zelltypen (targeted drug delivery) ist ein potentielles Anwendungsgebiet dieser Ergebnisse.
Chemieparks: Industrie‐Landschaftspflege à la Germany
Authors: von Zedlitz M. 
Published: June 2010

AbstractChemieparks sind ein relativ neues und vor allem typisch deutsches Modell. Sie bieten den dort ansässigen Unternehmen sowie nationalen und internationalen Investoren vielfältige Vorteile: branchen‐optimale Rahmenbedingungen, individuelle Lösungen für Geschäftsmodelle sowie unterschiedliche Dienstleistungen von A wie Abfallentsorgung bis Z wie Zugangskontrolle.
Vom Anlagenverbund zum Entsorgungsnetzwerk
Authors: Brückner J. 
Published: June 2010

AbstractEine moderne, nachhaltige Chemieproduktion ist energie‐ und ressourceneffizient. Sie vermeidet Abfälle und schließt Kreisläufe, wo immer es technisch möglich und ökologisch und ökonomisch sinnvoll ist. Mit Anlagenverbünden, einer effizienten Entsorgungsinfrastruktur und einem umfassenden Entsorgungsmanagement unterstützen Chemieparks die Produktionsbetriebe auf ihrem Weg zu einer immer nachhaltigeren Chemieproduktion.
Behördenkommunikation
Authors: Brückner J. 
Published: June 2010

AbstractAnforderungen und Randbedingungen für den Austausch von Informationen zwischen Betreibern von Industrieanlagen und Behörden erweisen sich zu einem großen Teil als allgemeingültig, unabhängig davon, in welchem Umfeld ein Unternehmen produziert. Die Anforderungen werden anhand der Beispiele der Genehmigungsverfahren, Inspektionen und Betriebsstörungen erläutert.
Chemieparks und ihre Regionen
Authors: Höchst T. , Klingenberg R. , Grieger F. , Gersemann M. , von der Linden B. , Höchst T. 
Published: June 2010

AbstractIm Windschatten der Globalisierung entstanden in Deutschland regionale Wirtschaftsinitiativen. Trendsetter dieser Entwicklung waren die deutschen Chemieparks. Um die Bedeutung und die Attraktivität der Chemieparks national und international zu stärken, haben sich Chemieparks in Regionalinitiativen zusammengeschlossen. Mitglieder und Vertreter dieser Initiativen stellen sich vor und erläutern ihre Positionen und Ziele.
Synthese und Optimierung von Cellobioselipiden und Mannosylerythritollipiden
Authors: Rupp S. , Zibek S. , Günther M. , Hirth T. 
Published: June 2010

AbstractCellobioselipide und Mannosylerythritollipide sind viel versprechende Glykolipide mit Tensid‐ Eigenschaften, die bisher jedoch unzureichend für Anwendungszwecke z. B. als Zusatz von Reinigungs‐ und Körperpflegemitteln charakterisiert wurden. Durch gezielte Anpassung der Kultivierungs‐ und Prozessführungsstrategien wurde die getrennte Herstellung von Cellobioselipiden und Mannosylerythritollipiden aus Ustilago maydis untersucht und optimiert.
Infrastruktur als Erfolgsfaktor für Chemieunternehmen am Standort Deutschland
Authors: Henkel E. 
Published: June 2010

AbstractDie heutige Chemie‐ und Prozessindustrie in Deutschland ist das Ergebnis tiefgreifender Veränderungen innerhalb der europäischen, politischen und industriellen Landschaft. Hinzu kommt schließlich die Strategie vieler chemischer und pharmazeutischer Unternehmen, sich auf Kernaufgaben zu konzentrieren und weniger zentrale Aufgaben abzustoßen. Diese strukturelle Dynamik hat erheblichen Einfluss auf die chemische Industrie in Deutschland gehabt. Für Investoren, die neue Produktionseinheiten aufbauen wollen, hat sich dank dieses Prozesses ein breites Spektrum an ausdifferenzierten Dienstleistungen ergeben.
Glycosylation Enhances Peptide Hydrophobic Collapse by Impairing Solvation
Authors: Cheng Shanmei , Edwards Scott A. , Jiang Yindi , Gräter Frauke 
Published: June 2010

AbstractPost‐translational N‐glycosylation of proteins is ubiquitous in eukaryotic cells, and has been shown to influence the thermodynamics of protein collapse and folding. However, the mechanism for this influence is not well understood. All‐atom molecular dynamics simulations are carried out to study the collapse of a peptide linked to a single N‐glycan. The glycan is shown to perturb the local water hydrogen‐bonding network, rendering it less able to solvate the peptide and thus enhancing the hydrophobic contribution to the free energy of collapse. The enhancement of the hydrophobic collapse compensates for the weakened entropic coiling due to the bulky glycan chain and leads to a stronger burial of hydrophobic surface, presumably enhancing folding. This conclusion is reinforced by comparison with coarse‐grained simulations, which contain no explicit solvent and correspondingly exhibit no significant thermodynamic changes on glycosylation.
Retinal patterning by Pax6‐dependent cell adhesion molecules
Authors: Rungger‐Brändle Elisabeth , Ripperger Jürgen A. , Steiner Kurt , Conti Alain , Stieger Ariane , Soltanieh Sahar , Rungger Duri 
Published: June 2010

AbstractLong‐standing evidence gained from Pax6 mutant embryos pointed to an involvement of Pax6‐dependent cell adhesion molecules in patterning the central nervous system and, in particular, the retina. However, direct evidence for such pathways remained elusive. We here present direct evidence that knockdown of Pax6 expression by morpholino antisense molecules in Xenopus embryos and knockdown of maternal N‐cadherin (mNcad), N‐cadherin (Ncad) and neural cell adhesion molecule (NCAM) produce similar phenotypes. Eye formation is reduced and retinal lamination is heavily disorganized. In Pax6 knockdown embryos, the levels of mRNAs coding for these cell adhesion molecules are markedly reduced. Overexpression of Pax6 efficiently rescues the phenotype of Pax6 knockdown embryos and restores expression of these putative target genes. Rescue of Pax6‐deficiency by the putative target gene mNcad moderately rescues eye formation. The promoters of the genes coding for cell adhesion molecules contain several putative Pax6 binding sites, as determined by computer analysis. Chromatin immunoprecipitation shows that, in embryonic heads, Pax6 binds to promoter regions containing such predicted binding sites. Thus, several cell adhesion molecules are direct target genes of Pax6 and cooperate in retinal patterning. © 2010 Wiley Periodicals, Inc. Develop Neurobiol 70: 764–780, 2010
Stochastic modelling of soil water and plant water stress using cumulant expansion theory
Authors: Kim Sangdan , Han Suhee , Kim Eungseock 
Published: June 2010

AbstractIn this study, a dynamic modelling scheme is presented to derive the probabilistic structure of soil water and plant water stress when subject to stochastic precipitation conditions. The newly developed model has the form of the Fokker–Planck equation, and its applicability as a model for the probabilistic evolution of soil water and plant water stress is investigated under climate change scenarios. This model is based on the cumulant expansion theory, and has the advantage of providing the probabilistic solution in the form of probability distribution function (PDF), from which one can obtain the ensemble average behaviour of the dynamics. The simulation result of soil water confirms that the proposed soil water model can properly reproduce the results obtained from observations, and it also proves that soil water behaves with consistent cycle based on the precipitation pattern. The plant water stress simulation shows two different PDF patterns according to the precipitation. Moreover, with all the simulation results with climate change scenarios, it can be concluded that the future soil water and plant water stress dynamics will differently behave with different climate change scenarios. Copyright © 2010 John Wiley & Sons, Ltd.
Light as a first‐order control on ecosystem structure in a temperate stream
Authors: Julian Jason P. , Seegert Sarah Z. , Powers Stephen M. , Stanley Emily H. , Doyle Martin W. 
Published: June 2010

AbstractAn emerging issue in ecohydrology is the role of light in fluvial ecosystem dynamics. Here, we investigate how photosynthetically active radiation (PAR) influences the hydrogeomorphology and biogeochemistry of a second‐order temperate stream with varying riparian communities from heavily shaded forest sections to unshaded grass sections. First, in‐stream PAR was compared to submerged aquatic macrophyte distributions along a 1·2‐km reach. The effects of macrophytes on water depth, sediment size, sediment volume, organic matter (OM) accumulation and nutrient uptake were then analysed. Compared with forested sites, non‐forested sites had three times more benthic PAR, which resulted in a quadrupling of macrophyte biomass. This greater biomass at non‐forested sites increased water depth, sediment accumulation and the uptake of soluble reactive phosphorous (SRP). Bed sediment size and OM were not significantly different between forested and non‐forested sites. Finally, we used the above relations to estimate biogeochemical differences between a completely forested reach and a non‐forested reach. Compared with a forested reach, the non‐forested reach accumulated almost twice as much bed sediment and retained more than four times as much SRP. Thus, changes in riparian conditions may create a cascade through which shading drives changes in stream habitat, which in turn drives changes in hydrogeomorphology and biogeochemical cycles. Copyright © 2010 John Wiley & Sons, Ltd.
IL‐6: Regulator of Treg/Th17 balance
Authors: Kimura Akihiro , Kishimoto Tadamitsu 
Published: June 2010

AbstractIL‐6 is a pleiotropic cytokine involved in the physiology of virtually every organ system. Recent studies have demonstrated that IL‐6 has a very important role in regulating the balance between IL‐17‐producing Th17 cells and regulatory T cells (Treg). The two T‐cell subsets play prominent roles in immune functions: Th17 cell is a key player in the pathogenesis of autoimmune diseases and protection against bacterial infections, while Treg functions to restrain excessive effector T‐cell responses. IL‐6 induces the development of Th17 cells from naïve T cells together with TGF‐β; in contrast, IL‐6 inhibits TGF‐β‐induced Treg differentiation. Dysregulation or overproduction of IL‐6 leads to autoimmune diseases such as multiple sclerosis (MS) and rheumatoid arthritis (RA), in which Th17 cells are considered to be the primary cause of pathology. Given the critical role of IL‐6 in altering the balance between Treg and Th17 cells, controlling IL‐6 activities is potentially an effective approach in the treatment of various autoimmune and inflammatory diseases. Here, we review the role of IL‐6 in regulating Th17/Treg balance and describe the critical functions of IL‐6 and Th17 in immunity and immune‐pathology.
Healthier lipid combination as functional ingredient influencing sensory and technological properties of low‐fat frankfurters
Authors: Delgado‐Pando Gonzalo , Cofrades Susana , Ruiz‐Capillas Claudia , Jiménez‐Colmenero Francisco 
Published: June 2010

AbstractOil (healthier lipid combination of olive, linseed and fish oils)‐in‐water emulsions stabilized with different protein systems (prepared with sodium caseinate (SC), soy protein isolate (SPI) and microbial transglutaminase (MTG)) were used as pork backfat replacers in low‐fat frankfurters. Composition (proximate analysis and fatty acid profile), sensory analysis and technological (processing and purge losses, texture and colour) properties of frankfurters were analysed as affected by the type of oil‐in‐water emulsion and by chilling storage (2°C, 41 days). Frankfurters produced with oil combinations had lower levels of saturated fatty acids (SFA, 19.3%), similar levels of MUFA (46.9%) and higher levels of PUFA (33.6%) than control frankfurters (all pork fat) (39.3, 49.5 and 10.6%, respectively). PUFA/SFA and n‐6/n‐3 PUFA ratios in control sample were 0.27 and 9.27; in reformulated frankfurters the PUFA/SFA ratio was higher (1.7) and the n‐6/n‐3 PUFA ratio was lower (0.47). In general, frankfurters had good fat and water binding properties. Colour parameters were affected by formulation and storage time. Compared to control sample, frankfurters made with oil‐in‐water emulsions had higher (p<0.05) hardness, springiness and chewiness values. Emulsified oil stabilizing systems did not affect sensory characteristics of frankfurters, and all products were judged as acceptable.
Pd‐PEPPSI Complexes and the Negishi Reaction
Authors: Valente Cory , Belowich Matthew E. , Hadei Niloufar , Organ Michael G. 
Published: June 2010

AbstractAn overview of Pd‐PEPPSI complexes in the Negishi cross‐coupling reaction is presented. Preliminary evaluations of differentially substituted imidazolium salts that generate highly active cross‐coupling catalysts in situ provide the foundation for the development of an air‐ and moisture‐stable NHC‐based precatalyst: Pd‐PEPPSI‐IPr. The application of Pd‐PEPPSI‐IPr in sp3–sp3, sp3–sp2 (and vice versa), and sp2–sp2 Negishi cross‐couplings is reviewed. This allowed the systematic development of Pd‐PEPPSI‐IPent, a more sterically demanding, second‐generation catalyst that outperforms the IPr analogue in a variety of sp2–sp2 Negishi cross‐couplings. General routes for the preparation of organozinc reagents are also examined, and an additives study reveals the probable transmetallating species that is operative in these cross‐couplings. Mechanistic considerations of the Negishi cross‐coupling reaction based on experimental and computational studies are summarized and evaluated.
Practical Synthetic Approach to Chiral Sulfonimides (CSIs) – Chiral Brønsted Acids for Organocatalysis
Authors: He Hao , Chen Ling‐Yan , Wong Wai‐Yeung , Chan Wing‐Hong , Lee Albert W. M. 
Published: June 2010

AbstractA general approach to the synthesis of optically pure 3,3′‐diaryl chiral sulfonimides (CSIs) from racemic BINOL has been developed. ortho‐Lithiation is directed by the sulfonyl groups, and the resulting dihalides serve as the common precursors for the aryl‐substituted CSIs.
Influence of the Reaction Conditions on the Evolution of the Michael Addition of β‐Keto Sulfones to α,β‐Unsaturated Aldehydes
Authors: Alemán José , Marcos Vanesa , Marzo Leyre , García Ruano José Luis 
Published: June 2010

AbstractWe have studied the influence of different reaction conditions on the conjugated addition of β‐keto sulfones to α,β‐unsaturated aldehydes catalyzed by silyl prolinol ethers. Small changes in the starting material and/or in the experimental protocol are able to produce significant variations in the structures of the final products. The high chemical versatility of the resulting Michael adducts make possible their use in a variety of tandem and one‐pot reactions to afford polysubstituted cyclic products bearing multiple chiral centers.
A simple and efficient method for processing of cell lysates for two‐dimensional gel electrophoresis
Authors: Xavier Tessy , Sreepriya  , Ganesan Trivadi S. , Menon Krishnakumar N. 
Published: June 2010

AbstractSample preparation is one of the major issues in 2‐DE for the separation of proteins. Although a 100% representation of cellular proteins onto a 2‐DE is virtually impossible, maximum representation of cellular proteins compared with the original cell lysate is important in the subsequent analysis. We demonstrate that lysis of cells in urea/thiourea solution with subsequent sonication to disrupt the nucleic acids and concentration of the lysate using centri‐con led to enrichment of proteins. The procedure resulted in minimal nucleic acid contamination with better resolution of spots. 2‐DE spot patterns of proteins prepared using urea–thiourea solubilization/centri‐con method to other protein enrichment methods such as phenol/chloroform/isoamyl alcohol extraction, methanol/ammonium acetate precipitation, acetone precipitation and ethanol precipitation were compared. Urea–thiourea solubilization combined with centri‐con method of protein enrichment represented higher number/unique spots particularly in the 50–250 kDa Mr compared with others. Lysis of cells in urea/thiourea from the beginning of lysate preparation preserves the proteins from protease activity due to denaturation of proteases. Thus, we demonstrate that the centri‐con methodology is simple and effective for the preparation of high‐quality sample that can be used for a qualitative representation of cellular proteins on a 2‐DE for proteomic analysis.
Bacterial cytotoxicity of the silver nanoparticle related to physicochemical metrics and agglomeration properties
Authors: Bae Eunjoo , Park Hee-Jin , Lee Jeongjin , Kim Younghun , Yoon Jeyong , Park Kwangsik , Choi Kyunghee , Yi Jongheop 
Published: June 2010

Abstract
Silver particles are used in various consumer products due to their positive effects, which include sterilization and antibacterial properties. However, it has been reported that silver nanoparticles (AgNPs) have strongly acute toxic effects on various cells. Therefore, the cytotoxicity of AgNPs was investigated, using Escherichia coli as a model organism, from the standpoint of three key metrics (ionic ratio, size, and agglomeration) that are the most relevant physicochemical properties. The findings indicated that cytotoxicity is depressed by the agglomeration of AgNPs. The order of toxic sensitivity was as follows: total Ag concentration &gt; ionic ratio &gt; size, the order of which was inversely related to the extent of agglomeration. Environ. Toxicol. Chem. 2010;29:2154–2160. © 2010 SETAC