bluuebunny/crossref_metadata_2025_split huggingface dataset:
Charge‐Site‐Dependent Dissociation of Hydrogen‐Rich Radical Peptide Cations upon Vacuum UV Photoexcitation
Authors: Madsen James A. , Cheng Ryan R. , Kaoud Tamer S. , Dalby Kevin N. , Makarov Dmitrii E. , Brodbelt Jennifer S. 
Published: March 2012

AbstractHere, 193 nm vacuum ultraviolet photodissociation (VUVPD) was used to investigate the fragmentation of hydrogen‐rich radical peptide cations generated by electron transfer reactions. VUVPD offers new insight into the factors that drive radical‐ and photon‐directed processes. The location of a basic Arg site influences photon‐activated CαC(O) bond cleavages of singly charged peptide radical cations, an outcome attributed to the initial conformation of the peptide as supported by molecular dynamics simulated annealing and the population of excited states upon UV excitation. This hybrid ETD/VUVPD method was employed to identify phosphorylation sites of the kinase domain of human TRPM7/ChaK1.
The General Phase Behavior of Mixtures of 1‐Alkyl‐3‐Methylimidazolium Bis[(trifluoromethyl)sulfonyl]amide Ionic Liquids with n‐Alkyl Alcohols
Authors: Vale Vlad R. , Will Stefan , Schröer Wolffram , Rathke Bernd 
Published: March 2012

AbstractThe liquid–liquid equilibrium (LLE) phase behavior of mixtures of 1‐ethyl‐3‐methylimidazolium bis[(trifluoromethyl)sulfonyl]amide (C2mimNTf2) with the n‐alkyl alcohols (CnOH; 3≤n≤8) is described. By applying the cloud‐point method, the LLEs were determined over a temperature range of 275–423 K at ambient pressure. Partial miscibility with upper critical solution temperatures (UCST) was observed. The UCST increase with increasing chain length of the alcohols. The phase diagrams were analyzed numerically by presuming Ising criticality. Concepts for the description of the asymmetry of the phase diagram by presuming the validity of the rectilinear diameter rule or a nonlinear diameter requested by the theory of complete scaling were applied. The results (UCST, critical composition, width and diameter of the phase diagrams) are compared with similar systems and discussed in terms of the corresponding state behavior; they map on a single curve. From at least 45 individual phase diagrams, general aspects of the behavior of this ionic liquid–alcohol mixture type were extracted. A simple empirical relationship was formulated to allow the description of the UCST with an accuracy of about 10 K when taking the ratio of the molar volumes of the alcohol and the 1‐alkyl‐3‐methylimidazolium cation of the ionic liquid into account.
Transgenic Xenopus laevis with the ef1‐α promoter as an experimental tool for amphibian retinal regeneration study
Authors: Ueda Yoko , Mizuno Nobuhiko , Araki Masasuke 
Published: March 2012

AbstractComplete retinal regeneration occurs after the removal of the whole tissue in mature Xenopus laevis, as well as in the newt. Here, we produced F1 and F2 lines of transgenic X. laevis containing an EGFP gene under a translation elongation factor 1‐α (ef1‐α) promoter and investigated how the gene is reactivated in retinal pigmented epithelial (RPE) cells when the neural retina (NR) is removed. The results showed that EGFP expression is reduced in the adult ocular tissues of nonmanipulated transgenic animals, and EGFP‐expressing cells are occasionally found heterogeneously in the lens, NR and RPE tissues. During retinal regeneration, the EGFP gene is reactivated in the RPE and ciliary marginal cells. Transgenic animals were also used for a transplant study because of the genetic marker of the donor tissue. Transplanted RPE clearly transdifferentiated to regenerate the retina in the ocular chamber. This study is, to our knowledge, the first report of a transgenic study of amphibian retinal regeneration, and the approach is promising for future molecular analyses. genesis 50:642–650, 2012. © 2012 Wiley Periodicals, Inc.
Simple Tuning of the Optoelectronic Properties of IrIII and PtII Electrophosphors Based on Linkage Isomer Formation with a Naphthylthiazolyl Moiety
Authors: Xu Xianbin , Zhao Yongbiao , Dang Jingshuang , Yang Xiaolong , Zhou Guijiang , Ma Dongge , Wang Lixiang , Wong Wai‐Yeung , Wu Zhaoxin , Zhao Xiang 
Published: March 2012

AbstractBy tuning the substitution position of a thiazolyl group on the naphthalene system (α or β site), the distinctive electronic structures associated with these functional ligands have a substantial influence on both the photophysical behavior and electroluminescent (EL) performance of the resulting linkage isomers for two series of IrIII and PtII phosphorescent emitters. The photoluminescence wavelength can be redshifted by ca. 23 nm for the linkage isomers upon replacing the β‐substituted thiazolyl‐based ligand with its α‐substituted counterpart in the homoleptic series of IrIII phosphors. Furthermore, the bathochromic effect can be as much as ca. 42 nm for the heteroleptic IrIII phosphors and ca. 59 nm for the PtII compounds. Similarly, metallophosphors that bear β‐substituted ligands exhibit a different EL performance with respect to that of their linkage isomers with α‐substituted ligands. The best EL results associated with the triplet emitters chelated with β‐substituted ligands show a maximum brightness (Lmax) of 22563 cd m–2, an external quantum efficiency (ηext) of 12.88 %, a luminance efficiency (ηL) of 30.84 cd A–1, and a power efficiency (ηp) of 26.17 lm W–1, whereas the EL performance of their α‐counterparts was characterized by a peak Lmax of 8653 cd m–2, ηext of 6.18 %, ηL of 8.55 cd A–1, and ηp of 6.54 lm W–1. Owing to its unique electronic structure, the thiazolyl group is a good alternative to the pyridyl moiety to improve the EL performance of the metallophosphor. We have also demonstrated a simple and useful route to tune the functional properties of cyclometalated triplet emitters for EL applications.
Somatosensory mechanical response and digit somatotopy within cortical areas of the postcentral gyrus in humans: An MEG study
Authors: Inoue Ken , Nakanishi Kazuyoshi , Hadoush Hikmat , Kurumadani Hiroshi , Hashizume Akira , Sunagawa Toru , Ochi Mitsuo 
Published: March 2012

AbstractSomatosensory evoked fields in response to compression (termed as Co) and decompression (termed as De) of glabrous skin (D1, thumb; D2, index finger; D5, little finger) were recorded. Although estimated equivalent current dipoles (ECDs) following stimulation of D1 and D5 were larger, but not significantly larger, in decompression than in compression, those of D2 were significantly larger (P = 0.035). The ECDs were located in the postcentral gyrus in the order of D5De, D2De, and D1De medially, posteriorly, and superiorly in decompression but not in compression (z‐value, F = 2.692, P = 0.031). The average distance of ECDs between D1 and D5 was longer in decompression (12.8 ± 1.6 mm) than in compression (9.1 ± 1.6 mm). Our data suggest that the cortical response for the commonly used digit D2 is functionally different from those for other digits (D1 and D5) that the somatotopic variability is greater in compression. Hum Brain Mapp, 2013. © 2012 Wiley Periodicals, Inc.
Is CO2 fixation promoted through the formation of DBU bicarbonate salt?
Authors: Mizuno Takumi , Nakai Takeo , Mihara Masatoshi 
Published: March 2012

AbstractThe bicyclic amidines, 1,8‐diazabicyclo [5.4.0]undec‐7‐ene (DBU) and 1,5‐diazabicyclo[4.3.0] non‐5‐ene (DBN), were used for the chemical fixation of carbon dioxide. The promotion for CO2 fixation is often reported through the formation of a thermally unstable DBU or DBN bicarbonate salt. To examine the effects of the DBU or DBN bicarbonate salt, reactions of 2‐aminobenzonitrile with the DBU salt or DBN salt in dimethylformamide (DMF) were performed at 20°C for 24 h in argon or carbon dioxide (0.1 MPa). However, in all the cases, 1H‐quinazoline‐2,4‐dione was not obtained completely. In contrast with room temperature reactions, 2‐aminobenzonitriles and DBU bicarbonate salt in DMF reacted for 4 h under high temperature (80°C) and CO2 atmosphere (0.1 MPa) gave 1H‐quinazoline‐2,4‐diones in good to excellent yields. At high‐temperature conditions, DBU bicarbonate salt is decomposed to DBU and carbon dioxide. Also, the carbonylation of 2‐aminobenzonitrile using DBU and carbon dioxide afforded 1H‐quinazoline‐2,4‐dione in good yields under similar reaction conditions. These results suggest that the combination of DBU or DBN as a strong base and carbon dioxide is much more important than the in situ formation of DBU or DBN bicarbonate salt for the acceleration of CO2 fixation. © 2012 Wiley Periodicals, Inc. Heteroatom Chem 23:276–280, 2012; View this article online at wileyonlinelibrary.com. DOI 10.1002/hc.21014
Effect of an interdisciplinary rehabilitation program on quality of life in patients with head and neck cancer: Review of clinical experience
Authors: Eades Margaret , Murphy Jessica , Carney Siobhan , Amdouni Shafia , Lemoignan Josée , Jelowicki Marta , Nadler Michelle , Chasen Martin , Gagnon Bruno 
Published: March 2012

AbstractBackgroundPatients with head and neck cancer experience complex posttreatment challenges. In a preliminary uncontrolled study, we evaluated the extent to which they can benefit from an interdisciplinary rehabilitation program.MethodsTwenty‐seven patients completed an 8‐week nutrition‐rehabilitation program. Six‐minute walk distance (6MWD), body weight, symptom burden, distress, and quality of life were assessed at baseline and at the end of the program.ResultsPatients improved their mean 6MWD by 59 m (effect size = 0.8), and 78% of patients either maintained or increased their body weight. They also reported a clinically meaningful reduction in severity of insomnia, pain, weakness, anorexia, shortness of breath, depression and distress, and improvement in quality of life (effect sizes = 0.6–0.9). However, they reported no change in symptom interference with function.ConclusionAn interdisciplinary rehabilitation program may be beneficial to patients with head and neck cancer after treatment, but its effects should be evaluated in a controlled trial. © 2012 Wiley Periodicals, Inc. Head Neck, 2013
Facile One‐Pot Synthesis of Monosubstituted 1‐Aryl‐1H‐1,2,3‐triazoles from Arylboronic Acids and Prop‐2‐ynoic Acid (=Propiolic Acid) or Calcium Acetylide (=Calcium Carbide) as Acetylene Source
Authors: Yang Qing , Jiang Yubo , Kuang Chunxiang 
Published: March 2012

AbstractThe synthesis of monosubstituted 1‐aryl‐1H‐1,2,3‐triazoles was achieved in a one‐pot reaction from arylboronic acids and prop‐2‐ynoic acid or calcium acetylide (=calcium carbide), respectively, as a source of acetylene, with yields ranging from moderate to excellent (Scheme 1, Table 2). The reaction conditions were successfully applied to arylboronic acids, including analogs with various functionalities. Unexpectedly, the 1,2,3‐triazole moiety promoted a regioselective hydrodebromination (Scheme 2).
Three New C19‐Diterpenoid Alkaloids from Aconitum transsectum
Authors: Shen Yong , Ai Hong‐Lian , Cao Tuan‐Wu , Wang Jian‐Jun , Zi Shu‐Hui , Zhang Xue‐Mei , Chen Ji‐Jun 
Published: March 2012

AbstractThree new C19‐diterpenoid alkaloids, named aconitramines A (1), B (2), and C (3), were isolated from Aconitum transsectum. By UV, IR, 1D‐ and 2D‐NMR, and MS analyses, their structures were elucidated as 18‐methoxyvilmoraconitine, 18‐demethoxydolichotine A, and 18‐demethoxydolichotine B. Compound 1 is the second known C19‐diterpenoid alkaloid with a three‐membered ring formed by C(8), C(9), and C(10).
Synthesis of Some New 2‐Oxo‐N‐[(10H‐phenothiazin‐10‐yl)alkyl] Derivatives of Azetidine‐1‐carboxamides
Authors: Sharma Ritu , Samadhiya Pushkal , Srivastava S. D. , Srivastava S. K. 
Published: March 2012

AbstractThe synthesis of a new series of 4‐aryl‐3‐chloro‐2‐oxo‐N‐[3‐(10H‐phenothiazin‐10‐yl)propyl]azetidine‐1‐carboxamides, 4a–4m, is described. Phenothiazine on reaction with Cl(CH2)3Br at room temperature gave 10‐(3‐chloropropyl)‐10H‐phenothiazine (1), and the latter reacted with urea to yield 1‐[3‐(10H‐phenothiazin‐10‐yl)propyl]urea (2). Further reaction of 2 with several substituted aromatic aldehydes led to N‐(arylmethylidene)‐N′‐[3‐(phenothiazin‐10‐yl)propyl]ureas 3a–3m, which, on treatment with ClCH2COCl in the presence of Et3N, furnished the desired racemic trans‐2‐oxoazetidin‐1‐carboxamide derivatives 4a–4m. The structures of all new compounds were confirmed by IR, and 1H‐ and 13C‐NMR spectroscopy, FAB mass spectrometry, and chemical methods.
LINEAR RELATIONSHIP BETWEEN THE AUD/USD EXCHANGE RATE AND THE RESPECTIVE STOCK MARKET INDICES: A COMPUTATIONAL FINANCE PERSPECTIVE
Authors: Imam Tasadduq , Tickle Kevin , Ahmed Abdullahi , Guo William 
Published: March 2012

SUMMARYIn the recent era, computational intelligence techniques have found an increased popularity in addressing varied financial issues, including foreign exchange rate prediction. This article, through an intelligent system research framework, relates the Australian dollar (AUD)/US dollar (USD) exchange rate to the Australian and the US stock market indices. Information for exchange rate, All Ordinaries Index (AOI) and Dow Jones Industrial Average (DJI) for the trading days over the period January 1991–May 2011 is considered in this research. Utilizing a set of statistical and computational intelligence techniques, the research establishes that the AUD/USD exchange rate is best estimated by a linear forecast model compared with the nonlinear and ensemble‐based intelligent system models. This research further highlights that, among the competing linear models, the model with both the stock market indices and historical exchange rate values as the predictors is the best forecaster. Parameters of the linear model are deduced through a Monte Carlo stochastic approach. Relative importance of the predictors is also studied, and the influence of historical exchange rates, the immediate impact of AOI and the lagged effect of DJI are noted. Copyright © 2012 John Wiley & Sons, Ltd.
Phylogenetic and computational structural analysis of VP7 gene of group a human rotavirus G1P[8] strains obtained in Sapporo, Japan from 1987 to 2000
Authors: Nagaoka Yoshinobu , Tatsumi Masatoshi , Tsugawa Takeshi , Yoto Yuko , Tsutsumi Hiroyuki 
Published: March 2012

AbstractMany studies indicate that G1P[8] genotypes are the most prevalent rotavirus strains worldwide. Although two vaccines have been licensed and their value proven in many countries, continuous surveillance for genetic evolution of circulating rotavirus strains before and after the introduction of the vaccines is desirable. G and P typing were carried out on all field strains isolated during 1987–2000 in Sapporo, Japan. Phylogenetic analysis for the VP7 gene of rotavirus G1P[8] strains was performed. Amino acid substitutions were mapped on the predicted three‐dimensional VP7 protein image. G1P[8] genotype predominated. One hundred thirteen strains with G1P[8] genotype were analyzed. Phylogenetic studies of the VP7 gene classified these strains into three lineages. The mean estimated substitution rate was 7.25 × 10−4 nucleotide substitutions per site per year. One predominant lineage contained the mutant strains which had VP7 amino acid substitutions at residue 91 and 212 that is in the neutralization domains. They were estimated to locate in or near intersubunit boundary of VP7 trimer. It is suggested that the most prevalent G1P[8] lineage strains in Sapporo obtained some survival advantages by changing the neutralization domains of VP7. J. Med. Virol. 84:832–838, 2012. © 2012 Wiley Periodicals, Inc.
Molecular epidemiology of human rhinovirus infections in Kilifi, coastal Kenya
Authors: Onyango Clayton O. , Welch Stephen R. , Munywoki Patrick K. , Agoti Charles N. , Bett Ann , Ngama Mwanajuma , Myers Richard , Cane Patricia A. , Nokes D.J. 
Published: March 2012

AbstractThis study reports pediatric surveillance over 3 years for human rhinovirus (HRV) at the District Hospital of Kilifi, coastal Kenya. Nasopharyngeal samples were collected from children presenting at outpatient clinic with no signs of acute respiratory infection, or with signs of upper respiratory tract infection, and from children admitted to the hospital with lower respiratory tract infection. Samples were screened by real‐time reverse transcriptase polymerase chain reaction (real‐time RT‐PCR) and classified further to species by nucleotide sequencing of the VP4/VP2 junction. Of 441 HRV positives by real‐time RT‐PCR, 332 were classified to species, with 47% (155) being HRV‐A, 5% (18) HRV‐B, and 48% (159) HRV‐C. There was no clear seasonal pattern of occurrence for any species. The species were present in similar proportions in the inpatient and outpatient sample sets, and no significant association between species distribution and the severity of lower respiratory tract infection in the inpatients could be determined. HRV sequence analysis revealed multiple but separate clusters in circulation particularly for HRV‐A and HRV‐C. Most HRV‐C clusters were distinct from reference sequences downloaded from GenBank. In contrast, most HRV‐A and HRV‐B sequences clustered with either known serotypes or strains from elsewhere within Africa and other regions of the world. This first molecular epidemiological study of HRV in the region defines species distribution in accord with reports from elsewhere in the world, shows considerable strain diversity and does not identify an association between any species and disease severity. J. Med. Virol. 84:823–831, 2012. © 2012 Wiley Periodicals, Inc.
Seroreactivity against Epstein–Barr virus (EBV) among first‐degree relatives of sporadic EBV‐associated nasopharyngeal carcinoma in Indonesia
Authors: Hutajulu Susanna Hilda , Ng Nawi , Jati Baning Rahayu , Fachiroh Jajah , Herdini Camelia , Hariwiyanto Bambang , Haryana Sofia Mubarika , Middeldorp Jaap Michiel 
Published: March 2012

AbstractEpstein–Barr virus (EBV) infection and family history are significant risk factors associated with undifferentiated nasopharyngeal carcinoma. The presence of aberrant immunoglobulin A (IgA) antibodies against specific EBV antigens in healthy individuals can be predictive of the disease. Very limited reports explored the EBV IgA antibody presence within families of sporadic cases of nasopharyngeal carcinoma. This study aimed to determine whether EBV IgA was observed more frequently among family members of sporadic cases of nasopharyngeal carcinoma compared to community controls and evaluated the non‐viral factors as determinants of antibody level. First‐degree relatives of nasopharyngeal carcinoma patients (n = 520) and case‐matched community controls (n = 86) were recruited. Sera from all individuals were tested in standardized peptide‐based EBV IgA ELISA. Data on demographic variables and other exogenous factors were collected using a questionnaire through face‐to‐face interviews. A similar frequency of EBV IgA (cut‐off value/CoV 0.354) was observed in the first‐degree relatives of cases and in community controls (41.2% vs. 39.5%, P = 0.770). However, with a higher antibody level (OD450 = 1.000; about three times standard CoV), the relatives showed significantly higher frequency (36.9% vs. 14.7%, P = 0.011). When adjusted for all exogenous factors, the strongest factors associated with seropositivity are being a father (odds ratio/OR = 4.36; 95% confidence interval/CI = 1.56–12.21) or a sibling (OR = 1.89; 95% CI = 1.06–3.38) of a case of nasopharyngeal carcinoma. The higher level of EBV IgA seroreactivity in first‐degree relatives of sporadic cases of nasopharyngeal carcinoma compared to the general population supports the use of EBV IgA ELISA for screening among family members. J. Med. Virol. 84:768–776, 2012. © 2012 Wiley Periodicals, Inc.
Prevalence and genotype distribution of human papillomavirus infection among female sex workers in Guangxi, China: Implications for interventions
Authors: Li Hong‐Min , Liang Guo‐Jun , Yin Yue‐Ping , Wang Qian‐Qiu , Zheng Zhi‐Ju , Zhou Ju‐Jiao , Jiang Ning , Tan Guang‐Jie , Wang Baoxi , Chen Xiang‐Sheng 
Published: March 2012

AbstractHuman papillomavirus (HPV) infection is a major public health concern in women, but information on HPV among female sex workers in China is limited. The aim of the study was to estimate the prevalence and genotype distribution of HPV infection among female sex workers in two cities in Guangxi, China. A total of 811 female sex workers were recruited from venues between July and September of 2009. Data on socio‐demographic and behavior characteristics were collected, and cervical swabs were collected to determine HPV infection and genotype distribution. The overall prevalence of infection with any HPV type was 38.9%. HPV type 52 was the most prevalent type with prevalence of 11%, followed by HPV types 16, 58, 53, and CP8304, with prevalences of 6.5%, 5.7%, 5.6%, and 4.8%, respectively. HPV 16 or 18 accounted for 23.2% of all HPV positive cases. Age group <20 years was significantly associated with infection of the high‐risk and multiple types of HPV infection. A higher prevalence of multiple HPV infection was observed among female sex workers from the outdoor venues (14.0%; 95%CI, 10.6%–17.3%). These findings have important implications for developing HPV prevention programs including HPV vaccination in female sex workers. J. Med. Virol. 84:798–803, 2012. © 2012 Wiley Periodicals, Inc.
The temperature dependence of the bimolecular channels of the ClO + ClO reaction over the range T = 298–323 K
Authors: Ferracci Valerio , Rowley David M. 
Published: March 2012

AbstractThe bimolecular channels of the ClO self‐reaction, although negligible under stratospheric conditions, become significant above ambient temperature. The kinetics of two of the three bimolecular channels of the ClO self‐reaction, ClO + ClO → Cl2 + O2 (1b) and ClO + ClO → OClO + Cl (1d), were studied at T = 298–323 K and at ambient pressure (patm≈ 760 ± 10 Torr). Radicals were generated via laser photolysis and monitored using UV absorption spectroscopy. The inclusion of charge‐coupled device (CCD) detection allowed broadband monitoring of the radicals of interest along with the temporal resolution of their concentrations. Accurate and unequivocal quantification of the structured absorbers (ClO and OClO) was obtained via differential fitting procedures. The Arrhenius expressions obtained are k1b = 2.9−1.8+4.4 × 10−14exp[−(283 ± 282)/T] cm3 molecule−1 s−1 and k1d = 7.2−6.1+39 × 10−15exp[−(225 ± 574)/T] cm3 molecule−1 s−1, where the errors are 1σ. The temperature dependences obtained in this work for both channels monitored are considerably less pronounced than those reported by Nickolaisen et al. © 2012 Wiley Periodicals, Inc. Int J Chem Kinet 44: 386–397, 2012