bluuebunny/crossref_metadata_2025_split huggingface dataset:
Magnetic circular dichroism spectra of some 3‐arylfervenulins and 3‐aryltoxoflavins
Authors: Yamaguchi H. , Kuwata R. , Yoneda F. 
Published: April 2009

AbstractThe magnetic circular dichroism (MCU) spectra of some 3‐arylfervenulins and 3‐aryltoxo‐flavins were measured. From the dependence of the Faraday B values of 3‐arylfervenulins and 3‐aryltoxoflavins on the Hammet σpara values, it is concluded that the substituent effects on the Faraday B values of 3‐aryltoxoflavins are reverse to the substituent effects on the Faraday B values of 3‐arylfervenulins and the reverse property of 3‐aryltoxoflavins concerning the substituent effects rises from the contribution of the 1,5‐dipolar structure of 3‐aryltoxoflavins.
Photochimie d'hétérocycles azotés. IV. Transposition de type photo‐fries des N‐acétyl benzimidazolones
Authors: Bouchet Philippe , Joncheray Gerard , Jacquier Robert , Elguero José 
Published: April 2009

AbstractLa photolyse des N‐acé'tyl et N,N ‐diacétyl benzimidazolones en solution dans le benzéne ou l'alcool 95 conduit à des mélanges de produits de désacétylation, d'ortho‐transposition et de para‐transposition. Les différents produits obtenus ont été identifiés par rmn, spectrométrie de masse et synthése univoque.
Über die acetolysenprodukte der cyanhydrine von 4‐pyridazoin und 4‐pyridoin: Struktur und ungewöhnliche reaktivität 9. Mitteilung über pyridazine
Authors: Heinisch Gottfried , Luszczak Ernst , Mayrhofer Andreas 
Published: April 2009

Abstract4‐Pyridazoin‐eyanhydrin liefert mit Aeetanhydrid das 1,4‐Dihydropyridazin‐Derivat 2a. Die Strukturen von 2a und dem Pyridin‐Analogon 2b werden spektroskopisch gesichert. Bei Chromatographie auf Kieselgel, gefolgt von Elution mit Methanol reagiert 2a zum Pyridazin‐4‐carbonsäuremethylester, 2b liefert hingegen neben Isonicotinsäuremethylester 4‐Pyridymethyl acetat. Die Mechanismen dieser ungewöhnlichen Reaktionen werden diskutiert.
Reactivity of 4‐hydroxy‐2‐methyl‐7,8,9,10‐tetrahydrobenzo[h] quinoline towards base‐catalyzed cyclization, mannich and turpin reactions
Authors: Abbasi M. , Nasr M. , Zoorob H. H. , Michael J. M. 
Published: April 2009

AbstractMannich reaction upon 4‐hydroxy‐2‐methyl‐7,8,9,10‐tetrahydrobenzo[h]quinoline (1) as well as its nitration were studied. Condensation of the chloroquinoline 6b with sodium azide, benzylamine and ethanolamine gave the quinoline derivatives 6c, 6f and 6g, respectively. Phenylhydrazine and sodium borohydride effected reduction of the azidoquinoline 6c to the corresponding amino‐ and hydroxyamino derivatives 6d and 6e, respectively. Also, Turpin's reaction gave the benzoquinobenzoxazines 7a‐d when applied to 6b. Treatment of 6f, 6g with alkali and the condensation of 6b with glycine in alcoholic sodium carbonate solution afforded the imidazo[4,5‐c]quinoline derivatives 9a‐c, respectively.
A side reaction encountered in using the peptide coupling reagent N‐ethoxycarbonyl‐2‐ethoxy‐1,2‐dihydroquinoline (EEDQ)
Authors: Lombardino Joseph G. , Anderson Susan L. , Norris Charles P. 
Published: April 2009

AbstractAn unusual side reaction has been found during an attempt to form an amide link between 2‐aminothiazole and thiophene‐2‐carboxylic acid in the presence of EEDQ. Ethyl N‐(‐thiazolyl)‐carbamate (3) was isolated in significant amounts indicating that 2‐aminothiazole, and perhaps other heterocyclic amines, can react directly with EEDQ to form carbamates.
Organolithium addition to 5,6‐disubstituted pyrimidines
Authors: Bennett Gregory B. 
Published: April 2009

AbstractThe addition of organolithium reagents to the azomethine bond of 5,6‐disubstituted pyrimidines provided, in every case, a single adduct. When reacted with either ethyl chloro‐formate or hydrogen chloride, these adducts gave a single dihydro pyrimidine. The resulting N‐H dihydro pyrimidines were oxidized with potassium permanganate to the corresponding pyrimidines.
Synthesis of some 3‐aryl‐4‐oxothiazolin‐2‐yl‐[3‐(2‐aryl)indolyl]hydrazories
Authors: Agrawal A. K. , Hastogi V. K. , Parmar S. S. 
Published: April 2009

AbstractSeveral 4‐aryl‐l‐[3‐(2‐aryl)indolyl]‐3‐thiosemiearbazones and 3‐aryl‐4‐oxothiazolin‐2‐yl‐[3‐(2‐aryl)indolyl] hydrazones were synthesized as possible antilertility agents. J. Heterocyclic Chem., 15, 677 (1978)
Synthesis of l‐(N‐acelylpiperidino)‐4‐aryl semicarbazides as possible anticonvulsants
Authors: Misra R. S. , Dwivedi C. , Parmar S. S. , Singh S. P. 
Published: April 2009

AbstractSix 1‐(N‐acetylpiperidino)‐4‐aryl semicarbazides were synthesized from ethyl‐N‐piperidino‐aeetatc which on treatment with hydrazine hydrate was converted into N‐piperidinoacethydrazide. The resulting hydrazide on treatment with the appropriate arylisoeyanales formed l ‐(N‐acelyl‐piperidino)‐4‐aryl semicarbazides. Amongst these piperidinosemicarbazides, three compound possessed low anticonvulsanl activity and provided 20‐40% protection against pentylenetetrazol‐induced convulsions in mice. All piperidino semicarbazides (0.1 mM) possessed antihemolytic activity (13‐35%) and caused 40‐72% inhibition of monoamine oxidase activity of rat brain homogenates at a final concentration of 0.3 mM.
2,3,9,10‐Tetrachlorobenzo[1,2‐b: 4,5‐b']bis[1,4]benzodioxin, a homologue of TCDD
Authors: Oliver James E. , Lusby William R. 
Published: April 2009

AbstractCatechol and 4,5‐dichlorocatechol have been condensed with 1,5‐dichloro‐2,4‐dinitrobenzene to provide benzo[1,2‐b: 4,5‐b ]bis[1,4]benzodioxin and its 2,3,9,10‐tetrachloro derivative, respectively. The latter compound is a novel homologue of the extremely toxic 2,3,7,8‐tetrachloro‐dibenzo‐p‐dioxin (TCDD).
Systèmes aromatiques à 10 électrons π dérivés de l'aza‐3a pentalène. XXXII. Recherches dans la série du pyrazolo[1,5‐a]benzimidazole
Authors: Lazaro René , Elguero José 
Published: April 2009

AbstractLe probleme de l'aromatiuité d'un dérivé aza‐3a pentalénique, le méthyl‐2 pyrazolo[1,5‐a]‐benzimidazole, a été abordé par 1′étude de sa réactivité comparée à celle d'un produit modèle, le phényl‐1 méthyl‐3 amino‐5 pyrazole. La mono‐ et diprotonation, l'alcoylation, la quater‐narisation, la formylation, l'acétylation et le comportement des dérivés N‐acétylés ont été examinés. On eonclue à une structure aromatique fortement polarisée.
On the synthesis and animation of 5‐chloro‐and 5‐bromo‐1,7‐naphthyridine
Authors: Woźaniak M. , van der Plas H. C. 
Published: April 2009

AbstractA new synthesis of 5‐chloro‐ and 5‐bromo‐1,7‐naphthyridine, using 8‐amino‐1,7‐naphthyridine as starting material is described. On amination with potassium amide in liquid ammonia, the 5‐bromo compound undergoes a tele‐amination into 8‐amino‐ and 2‐amino‐1,7‐naphthyridine and a Chichibabin reaction yielding 8‐amino‐5‐bromo‐1,7‐naphthyridine. The reaction with the 5‐chloro compound occurs at a much lower rate than the 5‐bromo compound and only gives 8‐amino‐5‐chloro‐1,7‐naphthyridine in a small yield. Convincing 1H‐nmr evidence is presented, showing that the 5‐bromo‐ and 5‐chloro‐1,7‐naphthyridine give addition of the amide ion at position 8 and that the 5‐chloro compound also gives addition at position 2.
The knoevenagel condensation of ethyl acylpyruvates
Authors: Kurihara Takushi , Sakamoto Yasuhiko , Kobayashi Toshio , Mori Masanobu 
Published: April 2009

AbstractExtensive studies of the Knoevenagel condensation of aromatic aldehydes and active methyl‐lene compounds have been reported (2). In 1894, Knoevenagel reported (3) the reaction of benz‐aldehyde with ethyl benzoylpyruvate in the presence of piperidine to give ehtyl benzyl‐(bis‐benzoyl)pyruvate, m.p. 162°, but no yield of the product was reported. This paper deals with the interesting results of the reactions of ethyl acetylpyruvate (2) (4) and ethyl benzoylpyruvate (3) (5) with some aromatic aldehydes (1a‐f).
Zur darstellung der l‐(diazinyl)‐2‐(pyridyl)‐äthene (triazastilbene)
Authors: Felbecker H. , Hollenberg D. , Schaaf R. , Bluhm Th. , Perkampus H.‐H. 
Published: April 2009

AbstractIn Weiterführung unserer Untersuchungen an Azaanalogen des Stilbens warden die 18 isomeren l‐(Diazinyl)‐2‐(pyridyl)‐äthene (Triazastilbene) dargestellt. Zur Diskussion der Aktivierung der Methylgruppen und der Carbonylgruppen bei den Edukten für die Aldolkondensation wurden die Ergebnisse von Elektronendichteberechnungen nach der CNDO/2‐Methode herangezogen.
Carbon‐13 spectra of some tetrahydropyridines. The structure of the tetrahydropyridines from 3,5‐lutidine 1‐oxide and mercaptans in acetic anhydride
Authors: Kokosa John M. , Chu Ih , Bauer Ludwig , Hlgan Richard S. 
Published: April 2009

AbstractThe reaction of 3,5‐lutidine 1‐oxide (1) with t‐butyl mereaptan in acetic anhydride, with or without triethylamine, was reinvestigated. There was obtained 2‐t‐butylthio‐3,.5‐lutidine as the major product, a small quantity of 3‐(t‐bulylthio)methyl‐5‐picoline, 1‐acetyl‐2,3‐diacetoxy‐3,5‐dirnethyl‐6‐t‐butylthio‐1,2,3,6‐tetrahydropyridine (which represents a structure revision) and l‐acetyl‐2,6‐dihydroxy‐3‐t‐butylthio‐3,5‐dimethyl‐1,2,3,6‐tetrahydropyridine. A similar reaction of 1 with 1‐adamantyl mercaptan furnished 2‐(l‐adamantylthio)‐3,5‐lutidine and 1‐acetyl‐2,3‐diacetoxy‐3,5‐dimethyl‐6‐(1‐adamantylthio)‐1,2,3,6‐tetrahydropyridine. The structures of these new tetrahydropyridines were established primarily by carbon‐13 nmr spectra.
Etude de nouveaux systemes aromatiques possédant des propriétes diéniques: [2]benzothiéno[5,6‐g] phtalazines, thiéno[3,4‐g]phtalazines et leurs analogues furanniques
Authors: Lepage Lucette , Lepage Yves 
Published: April 2009

AbstractDe nouveaux systémes polydiéniques sont déerits: deux [2]benzothiéno[ 5,6‐g]phtalazines, analogues diazotés des anthra[2,3‐c] thiophénes ineonnus, une f'uro[3,4‐g]phtalazine et une thiéno[3,4‐g]phtalazine. Ces différents composés subissent la réaction de Diels et Alder. Des tetraza‐2,3,8,9 naphtacénes ont été synthetise's pour la première fois. Les structures de ces composés ont été démontrées par des méthodes chimiques et spectrographiques.
Synthesis and nuclear magnetic resonance spectra of 2H‐pyrido [1,2‐a] pyrimidin‐2‐ones
Authors: Al‐Jallo Hikmat N. , At‐Biaty Ibtisam A. 
Published: April 2009

AbstractReaction of ethyl phenylpropiolate with several 2‐aminopyridines afforded the corresponding 2H‐pyrido[1,2‐a] pyrimidin‐2‐ones in good yields. Analysis of the nmr spectra of these compounds and their hydrobromides were based on comparing their spectra with their 3‐deuterated analogues. It was found that in these 2‐oxo compounds, the proton at position‐7 is shielded and absorbs together with the olefinie proton at position‐3 in the region of 5 6.35‐6.70 ppm. The latter proton could be used for differentiating these compounds from the corresponding 4‐oxo isomers which have already been identified by the deshielded proton at pusition‐6 near § 9.0 ppm. The ir and nmr spectral data for all these compounds are tabulated and discussed.
Ring‐chain tautomerism of aldehyde n‐methylated semicarbazones
Authors: Uda Masayuki , Kubota Seiju 
Published: April 2009

AbstractRing‐chain tautomerism of thirty‐six aldehyde semicarbazones was studied by nmr spectro‐scopy. The 2,4‐dimethylsemicarbazones of benzaldehyde,p‐tolualdehyde,p‐anisaldehyde, andP‐chlorobenzaldehyde exist as chain forms in DMSO‐d6, but as both ring and chain forms in deuteriotriiluoroacetic acid. Unlike these semicarbazones, the aldehyde semicarbazones ofN‐unsubstituted semicarbazide, 2‐methylsemicarbazide, and 4‐methylsemicarbazide did not cyclo‐isomerize in either DMSO‐d6or deuteriotrifluoroacetic acid. These results indicate that protona‐tion of the C=N nitrogen atom and steric hindrance of the 2‐methyl group with an aromatic group at the C=N carbon atom in the chain form cause cycloisomerization to ring isomers.
Sels d'aziridinium stables, C‐fonctionnalisés
Authors: Pierre Jean‐Louis , Baret Paul , Rivoirard Eve‐Marie 
Published: April 2009

AbstractLa réaction de diverses aziridines C‐fonctionnalisées avec le fluorosulfonate de méthyle conduit avec des rendements élevés aux fluorosulfonates d'aziridinium correspondants. Ces composés sont caractérisés sans ambiguïté par voie chimique. La réaction d'ouverture des sels d'aziridinium par le chlorure de lithium est étudiée. Deux méthodes quantitatives de changement du contre‐ion sont décrites.
Synthesis and nuclear magnetic resonance spectra of fused pyrimidines
Authors: Al‐Jallo Hikmat N. , Muniem Muhamad A. 
Published: April 2009

AbstractEthy phenylpropiolate reacted with 2‐aminobenzothiazoles, benzimidazoles, thiazoline and thiazole to give the corresponding fused 2‐oxopyrimidines. 2‐Mercaptobenzimidazole reacted with ethyl phenylpropiolate to give 4‐phenyl‐2H‐1‐thiapyrimido(1,2‐a ]benzimidazol‐2‐one in very good yield. The thiones, methylthio iodides and the hydrobromides of some of the products were prepared. Analysis of the nmr spectra of the benzothiazole and benzimidazole products and their 3‐deuterio analogs showed that the proton at position 6 is shielded and absorbs together with the proton at position 3 near δ 6.0 ppm. The nmr and ir spectral data of all the products are tabulated and discussed.
Synthèse de dérivés O‐substitués du (dihydroxy‐3′,4′ phényl)‐2 indole par utilisation de groupes protecteurs sulfonylés
Authors: Bazile Yves , De Cointet Paul , Pigerol Charles 
Published: April 2009

AbstractOn synthétise les dérivés O‐substitués du (dihydroxy‐3′,4′ phényl)‐2 indole au départ d'acétovanillone par différentes méthodes qui mettent en évidence l'intérět du groupe protecteur benzènesulfonyle et méthylsulfonyle. En effet la protection de l'hydroxyle de l'acétovanillone par de tels groupements facilite la cyclisation de Fischer et, plus particulièrement, celle de Bischler. De plus, elle autorise les réactions de O‐déméthylation et de O‐alkylation sélectives. Enfin elle permet de régénérer aisément le groupe hydroxy greffé en position ‐4′ sur les (alkyloxy‐3′ phényl)‐2 indoles.
Synthesis of substituted 2‐ethyl‐3‐(4‐hydrazinocarbonylphenyl)‐4‐quinazo‐lones and 2‐ethyl‐3‐(4‐hydrazinocarbonylmethylphenyl)‐4‐quinazolones
Authors: Arora R. C. , Rastogi V. K. , Agrawal A. K. , Parmar S. S. 
Published: April 2009

AbstractSome substituted 2‐ethyl‐3‐(4‐hydrazinocarbonylphenyl)‐4‐quinazolones and 2‐ethyl‐3‐(4‐hydrazinocarbonylmethylphenyl)‐4‐quinazolones were synthesized and characterized by their sharp melting points, elemental analyses and spectral data.
Preparation of some tricyclic fused ring iminopyrido[3,2‐e]pyrimidines
Authors: Kwok Russell 
Published: April 2009

AbstractThe preparation of a number of tricyclic fused ring iminopyrido[3,2‐e]pyrimidines is described. Treatment of 2‐chloronicotinonitrile with primary amines afforded the corresponding 2‐amino derivative which was condensed with ethylenediamine or higher congeners to give substituted cyclic amidines. The latter on treatment with cyanogen bromide gave the desired imino‐pyrido[3,2‐e]pyrimidines. The preparation of diaminopyrido[2,3‐d]pyrimidines and tricyclic quinazolines by related procedures is discussed.
1H Nmr structural analysis of azabicyclospirohydantoins
Authors: Trigo G. G. , Galvez E. , Avendaño C. 
Published: April 2009

AbstractBased on the data from 1H nmr spectra, the structure and spatial configuration of the ahove mentioned hydantoins are established. In the 3‐alkyl‐3‐azabicyelo[3.3.f ]nonane‐9‐spiro‐5′‐hydantoins analyzed, we confirm the chair‐chair configuration and the presence of only one stereoisomer at the spiro carbon atom (with the C4′=() group axial with regard to the piperidine ring). In the 3,7‐dialkyl‐3,7‐diazabieyclo[3.3.1 ]nonane‐9‐spiro‐5′‐hydantoins analyzed, we also confirm the chair‐chair configuration and we calculate the percentage of the two stereoisomers when they exist.
Tricyclic heteroaromatic ring systems II A convenient synthesis of 1H‐pyrrolo[3,2‐c]quinolines
Authors: Khan Misbahul Ain , da Rocha João Ferreira 
Published: April 2009

AbstractVarious quinol‐4‐yl hydrazones on heating in high boiling solvents undergo cyclizations to give lH‐pyrrolo[3,2‐c]quinolines in good yields. Some of these pyrroloquinolines were alkylated to provide their N‐alkyl derivatives.
Indole and quinoline derivatives of 2,3‐dihydro‐l‐benzothiepin‐4(5H) one
Authors: Pellicciari Roberto , Natalini Benedetto , Ricci A. , Alunni‐Bistocchi G. , De Meo G. 
Published: April 2009

AbstractBy application of the Friedlander synthesis on 2,3‐dihydro‐l‐benzothiepin‐4(5H) one (4), the corresponding [4,5‐b]quinoline derivatives 5a and 5b were obtained. Starting from the ketone (4) and by application of the Fischer indole synthesis, 1‐benzolhiepino[4,5‐b ]indole (6) and 1‐benzothiepino[4,5‐b]benzo[g]indole (7) were obtained. When β‐naphthylhydrazine was used in the indolisation reaction, a mixture of 1‐benzothiepino[4,5‐b]benzo[e]indole (8) and 1‐benzothiepino[4,3‐b]benzo[e] indole (9) was obtained.
An infrared spectroscopic investigation on N‐methyl‐1,3‐thiazolidine‐2‐thione and ‐2‐selone
Authors: Devillanova Francesco A. , Verani Gaetano , Sathyanarayana D. N. 
Published: April 2009

AbstractAn infrared investigation cm N‐methyl‐1,3‐thiazolidine‐2‐thione and ‐2‐selone in the range 4000‐200 cm−1 is reported. The v CS and v CSe vibrations give contributions to the absorptions around 1000 cm−1 and below 600 cm−1. The assignments are supported by comparison of their ir spectra with those of S‐ and Se‐methiodides. The π‐bond orders of the thio‐ and seleno‐ketonic links in these compounds are higher than those found for 1,3‐imidazolidine‐2‐thione and ‐2‐selone.
Synthesis and thermal reaction of 2‐perfluoropropyl or (2‐pyridyl)‐5‐phenyl‐6‐[4‐(4‐ethynylphenoxy) phenyl] ‐as‐triazine
Authors: Hergenrother P. M. , Sykes G. F. , Young P. R. 
Published: April 2009

Abstract4‐(4‐Ethynylphenoxy) benzil was separately reacted with two amidrazones to provide acetylene‐containing phenyl‐as‐triazine products. Each product consisted of two isomers which were separated by high pressure liquid chromatography and analyzed by mass spectroscopy. Differential scanning calorimetry was employed to study the thermal reaction of the acetylene‐containing phenyl‐as‐triazine products. The principal component from the thermally induced reaction of the acetylene‐containing phenyl‐as‐triazine was identified by mass spectroscopy as a dimer.
Analogues of antipsychotic phenothiazines. 10‐(β‐dialkylamino) ethylaminophenothiazines
Authors: Corral Carlos , Lissavetzky Jaime , Quintanilla Gloria 
Published: April 2009

AbstractA series of 10‐(β‐dialkylaniino) ethylarninophenothiazines III was obtained by lithium alumi‐um hydride reduction of 10‐dialkylaminoacetylaminophenothiazines II. Compounds II were synthesized by intramolecular cyclization, via a Smiles rearrangement, of 2‐nitro‐2′‐(β‐dialkyl‐aminoacetyl) hydrazinodiphenyl sulfides I and XI, which in turn were best prepared by condensation of the appropriate dialkylaminoacetic acid hydrochloride with the corresponding 2‐nitro‐2′‐hydrazinodiphenyl sulfide in the presence of dicyclohexyl carbodiimide. Other attempted methods for the synthesis of compounds 1 are also described.
Polymethyl derivatives of furo[3,4‐c]pyran4‐one, furo[3,4‐c] pyridin‐4‐one and pyrrolo[3,4‐c]pyran‐4‐one
Authors: Giardina Dario , Ballini Roberto , Ferappi Marcello , Casini Giovanni 
Published: April 2009

AbstractThe: title compounds were prepared from Michael adducts, obtained from acetoacetic esters and trans‐3‐hexene‐2,5‐dione, and from the corresponding dehydration products, by direct cyclization to oxygen rings or by reaction with ammonia (or methylamine) to give nitrogen rings.
Cyelisation of arylcarboxamidouracils. Synthesis of a new 4H‐3,1‐benz‐oxazin‐4‐one. Use of mass spectrometry as a probe
Authors: Bernier Jean‐Luc , Hénichart Jean‐Pierre 
Published: April 2009

AbstractThe action of acetic anhydride on an anthranylcarboxamidouraeil led to a new 2‐substituted 4H‐3,1‐benzoxazin‐4‐one with potential analgesic activity. Mass spectrometry has been used as a method lor structure confirmation and several fragmentation pathways were proposed. Furthermore, an additional probe was given by opening of the lactonic ring submitted to the action of aliphatic and aromatic primary amines.
Synthesis of 8‐aza‐15‐hydroxy‐7‐oxo‐12S‐13E‐prostenoic acids
Authors: Zoretic P. A. , Sinha N. D. , Shiah T. , Maestrone T. , Branchaud B. 
Published: April 2009

AbstractThe synthesis of a prostaglandin E1 analog, 8‐aza‐15‐hydroxy‐7‐oxo‐12S‐13E‐prostenoic acid, is reported.
Aromatic systems with 10π electrons derived from 3a‐azapentalene. XXXV Quaternary salts of 3‐methyl‐s‐triazolo[4,3‐α]benzimidazole
Authors: de Mendoza Javier , Rull Pedro 
Published: April 2009

AbstractQuaternary salts with general structures 3 and 4 are obtained by reaction of 3‐methyl‐s‐tríazolo [4,3‐α]benzimidazole and its alkyl derivatives 1 and 2 (R ≠ H) with alkyl halides. Compound 1 quaternizes at N1 and N2, whereas 2 quaternizes only at N9. Compounds 3 and 4 are useful models for the study of the sites of protonation in this series. Structures are unequivocally assigned by hydrolysis and dealkylation.
1,2,3‐Triazolo[1,5‐c]pyrimidine, a novel heterocycle in the polyazaindolizine series
Authors: Maury Georges , Paugam Jean‐Paul , Paugam Renée 
Published: April 2009

AbstractThe synthesis and struetural properties of the novel heterocycle 1,2,3‐triazolo[1,5‐c]pyrimidine are described. No evidence of a triazole‐diazoalkylideneazine valence tautomerism process was observed at room temperature.
The 5‐chloro‐1‐alkoxy‐1,2,3‐benzotriazole system
Authors: McGee A. W. , Serve M. P. , Seybold P. G. 
Published: April 2009

AbstractThe 5‐chloro‐1‐alkoxy‐1,2,3‐benzotriazole system has been synthesized and characterized via its physical and chemical properties. HMO calculations predict the most reactive sites on the molecule.
3‐Benzoyl‐2‐hydroxy‐9‐methylpyrido[1,2‐A] pyrimidin‐4‐one
Authors: Yale Harry L. 
Published: April 2009

AbstractThe single aberrant product of the reaction between 2‐amino‐3‐methylpyridine (2) and ethyl benzoylacetate (4) in diethylbenzene at ca. 180° was 3‐benzoyl‐2‐hydroxy‐9‐methylpyrido‐[1,2‐a]pyrimidin‐4‐one (5). When administered to naive rats, 5 induced behavioral effects strikingly similar to those manifested by morphine‐addicted rats who have been deprived of that analgetic.
Conversion of 2‐(O‐hydroxyphenyl) alkyl ketones into 2‐hydroxymethylchroman derivatives
Authors: Bravo Pierfrancesco , Ticozzi Calimero 
Published: April 2009

Abstract2‐Hydroxymethylchromans are the only products arising from the oxidation by m‐chloro‐perbenzoic acid of the β‐(o‐hydroxyphenyl) olefins VI, obtained in turn form 2‐(o‐hydroxy‐phenyl) alkyl ketones (I) by the Wittig olefination with triphenylphosphonium methylide.
Structural reassignment of the condensation product of the 2‐phenylimidazole‐4,5‐dione benzamidinium salt
Authors: Braun Siegmar , Hafner Klaus 
Published: April 2009

AbstractIt is shown by 13C nmr spectroscopy that the thermolysis and dehydration of the 2‐phenyl‐imidazole‐4,5‐dione benzamidinium salt (1) yield 2‐cyano‐4,6‐diphenyl‐1,3,5‐triazine (7) and not as postulated previously, 2,5‐diphenylimidazo[4,5‐d]imidazole (3) as the reaction product.
Analgetika. VIII. Fluoralkylsubstituierte 2‐(äthylamino)pyrimidine
Authors: Kreutzberger Alfred , Leyke‐Röhling Swanhild 
Published: April 2009

AbstractDurch Fluoralkylgruppen substituierte 2‐(Äthylamino)pyrimidine (3) können durch Umsetzung von Äthylguanidin (1) mit entsprechend substituierten β‐Diketonen (2) erhalten werden. Innerhalb der Verbindungsklasse 3 finden sich Vertreter mit analgetischer, entzündungshemmender und antimykotischer Wirksamkeit.
On the vinyl group photooxygenation of bilirubin‐like model compounds
Authors: Lightner D. A. , Park Y‐T. 
Published: April 2009

AbstractThe photooxygenation of z‐3‐vinyl‐4‐methyl‐5‐(phenylmethylidene)‐3‐pyrrolin‐2‐one (1) and z‐5′‐oxo‐4′‐viny1–4‐ethyl‐3′,3,5‐trimethyl‐1′,5′‐dihydro(2,2′)dipyrromethene (2) reveals no reaction at the vinyl groups; hence, none is expected at the vinyl groups of bilirubin IXα, and none has been found.