bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dietary risk factors for colorectal cancer in Uganda: a case-control study
Authors: Wismayer Richard , Kiwanuka Julius , Wabinga Henry , Odida Michael 
Published: June 2024

Abstract
Introduction
Low-income countries in East Africa have a lower incidence of colorectal cancer (CRC) than high-income countries; however, the incidence has steadily increased in the last few decades. In Uganda, the extent to which genetic and environmental factors, particularly dietary factors, contribute to the aetiology of CRC is unclear. Therefore, the objective of our study was to determine the relationship between dietary factors and CRC in Uganda.

Methods
We conducted a case-control study and recruited 128 cases and 256 controls, matched for age (± 5 years) and sex. Data regarding the frequency of consumption of the dietary factors were obtained from all the participants using an interview-based questionnaire. The potential dietary risk factors and protective factors evaluated included the type and frequency of meat consumed and the type and frequency of high-fibre foods consumed. The frequency was either 4 or more times/week, 2–3 times/week, once/week or never. Conditional logistic regression analyses were used to determine the odds ratios associated with the different risk and protective factors.

Results
The median age (IQR) for the case participants was 55.5 (43-67.5) years, and that of the control participants was 54 (42–65) years. The male-to-female ratio was 1:1 for all the participants. Factors significantly associated with CRC cases included:- the consumption of boiled beef 2–3 times/week (aOR:3.24; 95% CI: 1.08–9.69; p < 0.035). Consumption of high-fibre foods, including:- millet for ≥ 4 times/week (aOR: 0.23; 95% CI: 0.09–0.62; p = 0.003)), spinach for ≥ 4 times/week (aOR:0.32; 95% CI: 0.11–0.97; p = 0.043), and potatoes 2–3 times/week (aOR: 0.30; 95% CI: 0.09–0.97; p = 0.044), were protective against CRC. Boiled cassava showed a tendency to reduce the likelihood of CRC when consumed ≥ 4 times/week (aOR:0.38; 95% CI: 0.12–1.18) however this did not reach statistical significance (p = 0.093).

Conclusions
The consumption of boiled beef increases the risk of CRC, while the intake of high-fibre foods may reduce the risk of CRC among Ugandans. We recommend nutritional educational programmes to increase public awareness regarding the protective role of a high-fibre diet and to limit the intake of cooked meat in our Ugandan population.
Knockdown of ATRX enhances radiosensitivity in glioblastoma
Authors: Zhao Yue , Chen Yifei , Liu Ruoyu , Liu Minghang , You Na , Zhao Kai , Zhang Jiashu , Xu Bainan 
Published: June 2024

Abstract
Background
Glioblastoma are highly malignant type of primary brain tumors. Treatment for glioblastoma multiforme (GBM) generally involves surgery combined with chemotherapy and radiotherapy. However, the development of tumoral chemo- and radioresistance induces complexities in clinical practice. Multiple signaling pathways are known to be involved in radiation-induced cell survival. However, the role of alpha-thalassemia X-linked mutant retardation syndrome (ATRX), a chromatin remodeling protein, in GBM radioresistance remains unclear.

Methods
In the present study, the ATRX mutation rate in patients with glioma was obtained from The Cancer Genome Atlas, while its expression analyzed using bioinformatics. Datasets were also obtained from the Gene Expression Omnibus, and ATRX expression levels following irradiation of GBM were determined. The effects of ATRX on radiosensitivity were investigated using a knockdown assays.

Results
The present study demonstrated that the ATRX mutation rate in patients with GBM was significantly lower than that in patients with low-grade glioma, and that patients harboring an ATRX mutation exhibited a prolonged survival, compared with to those harboring the wild-type gene. Single-cell RNA sequencing demonstrated that ATRX counts increased 2 days after irradiation, with ATRX expression levels also increasing in U-251MG radioresistant cells. Moreover, the results of in vitro irradiation assays revealed that ATRX expression was increased in U-251MG cells, while ATRX knockdown was associated with increased levels of radiosensitivity.

Conclusions
High ATRX expression levels in primary GBM may contribute to high levels of radioresistance. Thus ATRX is a potential target for overcoming the radioresistance in GBM.
Physical activity information-seeking behaviour and barriers in a sample of university undergraduate emerging adults: a cross-sectional survey
Authors: Idowu Opeyemi A. , Omoijahe Benedicta , Fawole Henrietta O. , Adeagbo Inioluwa , Akinola Bolarinwa I. 
Published: June 2024

Abstract
Background
Access to physical activity information provides opportunities for enduring and relevant messaging regarding physical activity. This may be a potential vehicle to optimise physical activity participation among emerging adults. This study aimed to characterise the physical activity information-seeking behaviour in a sample of university undergraduate emerging adults.

Methods
Five hundred and seventy-five undergraduate students (age = 21.7 ± 1.9 years) participated in the study. Respondents’ physical activity information-seeking behaviour was obtained using an adapted instrument, while physical activity and barriers were assessed using the International Physical Activity Questionnaire and the Exercise Benefits and Barrier Scale.

Results
Three hundred and fifty-one respondents (61%) of respondents sought physical activity information. The majority of these individuals (73.8%) sought physical activity information using social media. After identifying and controlling for confounders including engaging in physical activity programmes and faculty of study, having low physical activity levels was associated with a < 1 likelihood of seeking physical activity information compared to having high physical activity levels (odds ratio = 0.5, 95% confidence interval 0.27–0.87; p = 0.015). However, there was no association between barriers to physical activity and physical activity information-seeking behaviour (odds ratio = 1.17, 95% confidence interval 0.81–1.69; p = 0.40).

Conclusion
Undergraduate emerging adults seek physical activity information using social media to enhance their physical appearance and health.
Impact of frailty on patients hospitalized with myelodysplastic syndrome: A nationwide analysis.
Authors: Del Castillo Olivia , Javaid Saad , Frasier Kelly , Li Vivian , Vinagolu-Baur Julia , Rodriguez Evadne , Ortega Yaguachi Nataly , Batista Raquel , Jonas Kenlee , Palma Laura 
Published: June 2024

6569 Background: Myelodysplastic Syndrome (MDS) is a complex group of neoplasms that arises from abnormalities in the bone marrow's hematopoietic stem cells, leading to ineffective blood cell production. Frailty signifies increased vulnerability to internal and external stressors, with its impact on survival in MDS gaining recognition. We conducted a retrospective analysis to explore the impact of frailty on hospitalized MDS patients and its association with unfavorable hospital outcomes. Methods: National Inpatient Sample (NIS) 2019 and 2020 was utilized to identify the patients admitted with a primary diagnosis of MDS and had a concurrent diagnosis of Frailty. The Primary outcome was Mortality, and secondary outcomes included length of stay, total cost of hospitalization, and other adverse in-hospital outcomes. Multivariate logistic regression analysis was used to calculate the outcomes after adjusting for baseline sociodemographic characteristics. Results: A total of 17,000 patients were admitted with a primary diagnosis of MDS, among whom 4,285 (25.20%) patients had a concurrent diagnosis of Frailty. The mean age of patients with and without Frailty was 75.75 (+/-14.01) and 71.54 (+/-14.68), respectively, p<0.001. After adjusting for confounding variables, Frailty was considered an independent predictor of mortality in MDS patients (OR=1.80 (1.22-2.64); p=0.003). Patients with Frailty had a prolonged length of stay in the hospital (8.62 days(3.2-9.6) without and 11.56 days (4.6-12.1) with Frailty, P<0.001), as well as an increased total cost of hospitalization ($ 132159 (3256-23651) without and $173898 (5317-389146) with Frailty, p<0.001). Additionally, Frailty was associated with an increased likelihood of sepsis (OR=2.02 (1.33-3.06); p=0.001), acute kidney injury (OR=1.22 (1.02-1.50); p=0.04), major depressive disorder (OR=1.51 (1.19-1.91); p=0.001), and a higher association with chemotherapy (OR=3.46 (1.21-9.91); p=0.021) and palliative care (OR=2.23 (1.72-2.90); p<0.001). However, frail patients were less likely to receive blood transfusions (OR=0.73 (0.61-0.88); p=0.001), and no difference was noted in the risk of platelet transfusions (OR=0.95 (0.73-1.25); p=0.763). Conclusions: Frailty is considered an independent predictor of mortality and is associated with increased healthcare resource utilization along with other adverse in-hospital outcomes. Careful and thorough identification of frailty and its effective management is crucial for improving outcomes, reducing mortality, and enhancing the quality of life for patients with debilitating MDS. [Table: see text]
Disparities in the prevalence of acute pulmonary embolism in patients with ovarian cancer: A nationwide analysis.
Authors: Rodriguez Evadne , Javaid Saad , Frasier Kelly , Li Vivian , Vinagolu-Baur Julia , Ortega Yaguachi Nataly , Del Castillo Olivia , Batista Raquel , Jonas Kenlee , Palma Laura 
Published: June 2024

e17560 Background: Ovarian cancer is the leading cause of death among gynecological cancers. It is highly thrombogenic and is associated with increased venous thromboembolism events. We conducted a retrospective analysis to study the prevalence and disparities in the association of Acute Pulmonary embolism(PE) with ovarian cancer. Methods: National Inpatient Sample (2017-2020) was used to identify the patients with primary diagnosis of Acute PE and was stratified into those with and without concurrent diagnosis of Ovarian cancer ( regional and advanced metastatic disease). Basic demographic variables were analyzed to identify disparities in the prevalence of Acute PE among ovarian cancer patients.Multivariate logistic regression analysis was conducted to examine the association between Acute PE and Ovarian cancer. Results: A total of 651435 patients were hospitalized with a primary diagnosis of Acute PE, and 2980 (0.46%) had a secondary diagnosis of Ovarian cancer. The ovarian cancer group had a greater percentage of white (73.4% vs.71.93%), Hispanics (7.98% vs. 6.04%), and fewer Black patients (15.78% vs. 19.86), p=0.021. Compared to the white, Black population with ovarian cancer (OR=0.77(0.6-0.9); p=0.04) had a decreased likelihood of developing Acute PE without any difference noted in the Hispanics (OR=1.13 (0.81-1.58); p=0.44) and other races (OR=1.11 (0.67-1.83); p=0.67). Patients in the high income groups were more likely to be admitted due to acute PE ($65,000-$85,999: OR=1.35 (1.05-1.73), p=0.018; >$86,000: OR=1.24 (1.14-1.62), p=0.01). A greater percentage of patients with ovarian cancer had private insurance (35.2% vs. 28.91%), while a greater percentage of patients without ovarian cancer had Medicare (54.38% vs. 50.34%) and Medicaid (11.9% vs. 12.5%), p=0.003. Patients with private insurance were more likely to be admitted due to acute PE (OR=1.73(1.36-2.22); p<0.001). Patients with a Charlson comorbidity index of 3 or more had higher odds of Acute PE (OR=1.3(1.12-3.4); p=0.02). A greater percentage of Acute PE patients with ovarian cancer were admitted to large (54.03% vs. 47.86%; p=0.014), urban (95.3% vs. 90.35%; p<0.001), and teaching hospitals (79.87% vs. 69.15%; p<0.001). Teaching hospitals had higher odds of admissions due to acute PE in ovarian cancer patients (OR=1.37(1.07-1.75); p=0.01). On multivariate regression analysis, Ovarian cancer patients had higher odds of Acute PE (OR=1.88 (1.73-2.05); p<0.001). Conclusions: Ovarian cancer patients with Black race and private insurance showed a significantly increased likelihood of admissions due to acute pulmonary embolism. Additionally, urban and teaching hospitals demonstrated higher odds of encountering cases of acute pulmonary embolism. Further prospective studies are necessary to validate the findings presented in our study.
The spectrum consistency of fractional quantum Hall effect model
Authors: Del Cima O. M. , Lima L. S. , Miranda E. S. 
Published: June 2024

Abstract
The spectrum consistency of the three-fermion family

quantum electrodynamics in three space-time dimensions is analyzed. It has been verified that the originally proposed action violates the unitarity consistency condition in the gauge field sector by exhibiting negative norm states in the spectrum. However, the cure came through the fundamental gauge fields properly settled, consequently, the action rewritten in terms of those fundamental fields shows to be free from any spurious degrees of freedom, and the model now becomes safe for further quantization.
Novel complexiton solutions to the new extended (3+1)-dimensional Boiti-Leon-Manna-Pempinelli equation for incompressible fluid
Authors: Wang Kang-Jia , Li Shuai 
Published: June 2024

Abstract
This letter focuses on exploring some novel exact solutions to the new extended (3+1)-dimensional Boiti-Leon-Manna-Pempinelli equation (BLMPE) that has a major role in incompressible fluid. Adopting the Cole-Hopf transformation, the bilinear form of the considered equation is successfully constructed. Then the singular complexiton solutions (SCSs) are developed by applying the ansatz function method with a novel functional form. Additionally, we also find the non-singular complexiton solutions (NCSs) via imposing the restrictive conditions. To unveil the behaviors of the attained solutions better, the corresponding outlines are plotted via Maple.
Learning performance and GABAergic pathway link to deformed wing virus in the mushroom bodies of naturally infected honey bees
Authors: Szymański Szymon , Baracchi David , Dingle Lauren , Bowman Alan S. , Manfredini Fabio 
Published: June 2024

ABSTRACT
Viral infections can be detrimental to the foraging ability of the western honey bee, Apis mellifera. The deformed wing virus (DWV) is the most common honey bee virus and has been proposed as a possible cause of learning and memory impairment. However, evidence for this phenomenon so far has come from artificially infected bees, while less is known about the implications of natural infections with the virus. Using the proboscis extension reflex (PER), we uncovered no significant association between a simple associative learning task and natural DWV load. However, when assessed through a reversal associative learning assay, bees with higher DWV load performed better in the reversal learning phase. DWV is able to replicate in the honey bee mushroom bodies, where the GABAergic signalling pathway has an antagonistic effect on associative learning but is crucial for reversal learning. Hence, we assessed the pattern of expression of several GABA-related genes in bees with different learning responses. Intriguingly, mushroom body expression of selected genes was positively correlated with DWV load, but only for bees with good reversal learning performance. We hypothesise that DWV might improve olfactory learning performance by enhancing the GABAergic inhibition of responses to unrewarded stimuli, which is consistent with the behavioural patterns that we observed. However, at higher disease burdens, which might be induced by an artificial infection or by a severe, natural Varroa infestation, this DWV-associated increase in GABA signalling could impair associative learning as previously reported by other studies.
Inferring the Unofficial Incomes of Officials from Home Ownership
Authors: Deng Yongheng , Wei Shang-Jin 
Published: June 2024

We estimate the size of the likely unofficial income of the government official household by assessing the difference between the income necessary to explain their observed home purchase behavior and the official income. Using unique and comprehensive House Provident Fund and home purchases data between 2006 and 2013 in a large Chinese city, we reach three conclusions. First, an average official’s unofficial income is 83% of her official income; this percentage increases sharply with the official’s rank. Second, about 13% of the officials have an unofficial income, and the proportion also increases with rank. Third, government officials are not underpaid, and their unofficial incomes are not compensation for low government salaries. Additionally, evidence suggests that unofficial incomes have declined since the recent anticorruption campaign. An analysis of a separate crosscity data set corroborates the key conclusion. This paper was accepted by David Sraer, finance. Supplemental Material: The online appendix and data files are available at https://doi.org/10.1287/mnsc.2021.01725 .
Signaling Targeting Cost Through List Price
Authors: Yu Peiwen , Zhang Jiahua 
Published: June 2024

Data analytics enable firms to offer personalized prices to targeted consumers but at a cost. We study a competitive personalized pricing game where the entrant is uncertain about the incumbent’s targeting cost. We demonstrate that implementing personalized pricing through a “list price-discount” scheme allows the incumbent to signal its targeting cost via the list price. This signaling mechanism is effective because the list price serves as a price ceiling, which limits the incumbent’s ability to extract consumer surplus through personalized discounts. The high-cost incumbent can strategically set its list price below the full-information level to separate itself from the low-cost incumbent. Interestingly, the high-cost incumbent prefers separating over pooling only when there is a moderate variation in the incumbents’ targeting costs. Personalized pricing can affect firms differently, benefiting the incumbent but hurting the entrant. Asymmetric information about targeting costs weakens the high-cost incumbent’s incentive to offer personalized discounts, resulting in lower total targeting costs and potentially increasing social surplus. These findings shed light on government regulations and transparency policies regarding personalized pricing. This paper was accepted by Dmitri Kuksov, marketing. Funding: P. Yu was supported by the National Natural Science Foundation of China [Grants 72371038 and 72033003]. J. Zhang was supported by the National Natural Science Foundation of China [Grants 72371061 and 72232001]. Supplemental Material: The online appendices are available at https://doi.org/10.1287/mnsc.2023.02031 .
Restoring a smile: full-mouth rehabilitation of an elderly patient
Authors: Kulathunga IDP , Goonathilake WPAW 
Published: June 2024

Tooth wear is a significant problem in the ageing population and has increased in prevalence over the last century owing to the increase in life expectancy. Further, with the advances in dentistry, people tend to retain more of their natural dentition until the seventh or eighth decade of their lives and leading to an increased number of people with tooth wear. A certain degree of physiological tooth wear is inevitable over a lifetime as a result of the continuous function of the dentition. CPD/Clinical Relevance: A removable prosthesis, used in patients with severely worn teeth, is cost-effective compared to other prosthetic options and can be easily maintained hygienically.
Terahertz wide range phase manipulation with super-resolution precision by near-field nonlinear coupling of a digitally coding needle meta-chip
Authors: Liang Huajie , Zeng Hongxin , Zhou Tianchi , Zhao Hanyu , Gu Shaokang , Zou Lin , Jiang Tao , Wang Lan , Lan Feng , Liang Shixiong , Feng Zhihong , Yang Ziqiang , Zhang Yaxin 
Published: June 2024

Achieving ultra-precise wide-range terahertz (THz) phase modulation has been a long-standing challenge due to the short wavelength and sensitive phase of THz waves. This paper proposes a new ultra-high precision phase control method employing a digitally coding needle meta-chip embedded in a waveguide. The needle tips can effectively couple THz waves via the charge aggregation effect. By controlling the Schottky diodes with coding voltages, the charge on each meta-structure part can be tuned to form strong or weak resonances, producing phase shifts. Crucially, the massive charge accumulation and the sub-λ/10 distance between needle tips lead to near-field coupling among multiple tips. Therefore, modulation of the charge at each tip by multichannel coding voltages enables combined resonance tuning of THz waves, yielding a nonlinear phase superposition. Here, a meta-chip containing 8 needle meta-structure units is demonstrated, which breaks through the precision limitation of independent units and realizes super-resolution precision phase modulation similar to super-resolution imaging. In the 213–227 GHz band, we achieve a phase shift exceeding 180° with 11.25° accuracy, and a phase shift of over 170° with an accuracy of 3°. This super-resolution phase modulation strategy provides a new idea for future high-precision applications of THz integrated systems.
Employee Relations, Tacit Knowledge Sharing Activities, And Employee Performance in Social Exchange Theory Perspective
Authors: Pradhanawati Ari , Dewi Reni Shinta , Kusuma Chusnu Syarifa Diah 
Published: June 2024

Modern-day enterprise competition is getting more difficult, in particular in the industry 4.0 generation. SMEs or Small and medium-sized corporations as a part of the pillar in the economic industries, want to assume these conditions. Batik is an SME that has contributed to the economic system. various issues are confronted by way of the batik enterprise, together with SMEs in Batik in Semarang. They face a few barriers, inclusive of increasing the capability of human resources. knowledge sharing is an activity to enhance individual talents, specifically trouble-solving and worker self-assurance. Knowledge sharing is an activity to improve individual skills, especially problem-solving and employee confidence. The purpose of this examination turned into exploring the effect on tacit knowledge-sharing activities, employee performance and employee relations. Also, the article defined the activity of tacit knowledge sharing in mediating the effect of employees relation and employee performance. The type of research was explanatory research. The sample was a hundred employees within the SMEs Batik in Semarang. Statistics evaluation of the use of SEM. The finding showed that there was an effect of employee relations on tacit knowledge-sharing activities. Second, there was an effect of tacit knowledge-sharing activities on employee performance. And, employee relations and employee performance had a positive effect. The results of the mediation effect test showed that employee relations have a positive effect on employee performance through tacit knowledge-sharing activities. The suggestion of this research is Batik UKM in Semarang to create a conducive work environment because the results of the study show that the relationship between employees is a success factor in sharing tacit knowledge. The limitation of this research is that the study was only conducted at the Batik UKM in Semarang, which resulted in a very limited generalization of the research findings. The limitation of this research is that the study turned into best carried out on the Batik UKM in Semarang, which led to a totally limited generalization of the research findings. The difficulty of the have a look is that the observation turned into only carried out at the SMEs Batik in Semarang which makes a completely constrained generalization of the findings.