bluuebunny/crossref_metadata_2025_split huggingface dataset:
ANALISA KARAKTERISTIK SEDIAAN MASKER PEEL-OFF DARI LIMBAH CANGKANG TELUR DENGAN PENAMBAHAN BUBUK KULIT BATANG KAYU MANIS
Authors: Lubis Muhammad Irvan Maulana , Muarif Agam , ZA Nasrul , Azhari Azhari , Muhammad Muhammad 
Published: May 2024

Masker peel-off merupakan masker yang berbentuk gel yang di aplikasikan ke kulit dan dalam waktu tertentu akan membentuk lapisan film transparan yang elastis, setelah kering masker dapat langsung diangkat tanpa perlu dibilas, Masker wajah tentu memiliki banyak manfaat sesuai dengan jenis bahan utama yang terkandung dalam produk tersebut mulai dari mencerahkan wajah, memudarkan bekas jerawat, mengecilkan pori-pori hingga menyamarkan garis-garis halus pada wajah, Pada penelitian ini penulis menambahkan bubuk batang kayu manis sebagai zat aktif, dan dmdm hidantoin sebagai pengawet, pengujian juga dilakukan selama 1 minggu lama penyimpanan untuk mengamati karakteristik sediaan dengan variasi perbandingan PVA (8, 10, 12 gram) dan CMC (0, 1, 3, 5 gram), dari masing-masing sediaan dilakukan uji evaluasi, meliputi: organoleptik, daya sebar, waktu kering, homogenitas, dan pH. Hasil penelitian menunjukkan bahwa variasi massa sediaan memberikan pengaruh pada sifat fisika masker, hasil evaluasi dapat disimpulkan bahwa sediaan masker dengan perbandingan 10 gram PVA dan 1 gram CMC, merupakan formula yang memenuhi SNI, dengan nilai pH 7,3-7,5, daya sebar 5-5,1 cm, waktu kering 25-26 menit, kestabilan homogenitas yang baik, dan uji organoleptik yang paling banyak disukai.
The endaural subtemporal keyhole: a novel minimally invasive approach to the middle cranial fossa
Authors: Olszewski Adam M. , Hattar Ellina , Curry Steven D. , Peng Kevin A. , Lekovic Gregory P. 
Published: May 2024

OBJECTIVE
The goal of this study was to evaluate the feasibility of a minimally invasive approach to the middle cranial fossa using a novel endaural keyhole.

METHODS
The charts of all patients who underwent this novel minimally invasive approach to the middle cranial fossa were retrospectively reviewed. In addition, cadaveric dissection was performed to demonstrate the feasibility of the endaural keyhole to the middle cranial fossa.

RESULTS
Six patients (5 female and 1 male; age range 47–77 years) who underwent craniotomy for CSF leak (n = 3), intracerebral hematoma evacuation (n = 2), and tumor resection (n = 1) via the endaural subtemporal approach were identified. There were no approach-related complications noted. Representative imaging from cadaveric dissection is provided with a stepwise discussion of the procedure.

CONCLUSIONS
The endaural subtemporal keyhole craniotomy provides a novel approach to middle fossa skull base pathology, as well as a minimally invasive approach to intra-axial pathology of the temporal lobe and basal ganglia. Further research is needed to establish the limitations and potential complications of this novel approach.
How the elastase-induced rabbit aneurysm heals following flow diverter treatment: a histopathological study
Authors: Dai Daying , Bilgin Cem , Ding Yonghong , Ghozy Sherief , Mereuta Oana Madalina , Kallmes David F. , Kadirvel Ramanathan 
Published: May 2024

OBJECTIVE
Fibrin deposition is integral to thrombus formation and wound healing. The role of fibrin deposition and subsequent metabolism following flow diversion for aneurysm treatment remains poorly characterized. This study aimed to evaluate the role of fibrin in early thrombus organization after flow diverter treatment.

METHODS
Thirty-five elastase-induced aneurysms were induced in New Zealand white rabbits and subjected to endoluminal flow diversion treatment. The device-bearing arteries were harvested at 1, 3, and 6 months postimplantation and processed for histopathological examination, including a modified picro-Mallory stain (Carstairs method) to visualize fibrin and platelets, immunohistochemical targeting of smooth muscle actin (SMA), and H&E staining for conventional morphological evaluation. Quantitative analysis of tissue components was carried out using the Orbit Image Analysis software. The samples were also assessed qualitatively to investigate the morphology and location of fibrin and other thrombus components within the intra-aneurysmal thrombi. Statistical analyses were conducted using R software version 4.3.1.

RESULTS
Fibrin constituted 27.9% of the thrombus tissue within the aneurysm sac for aneurysms harvested at 1 month, and this rate was significantly lower in the 3-month group (10.2%, p = 0.018). The proportion of blood cells within the sac was also notably higher in the 1-month group compared with other time points. The primary tissue filling the dome at 1 month (14/15, 93%) was an unorganized thrombus primarily composed of fibrin, platelets, and red blood cells. Conversely, aneurysms harvested at 1 month had the lowest collagen level (25.6%). However, collagen became the dominant tissue component within the aneurysm sac, accounting for 71.8% of tissue in the 3-month group (p = 0.007). There were no differences observed among the examined components between the 3-month and 6-month groups. On qualitative analysis, collagen-producing SMA-positive myofibroblasts were located near or in between fibrin molecules. Healed aneurysms exhibited myofibroblasts, collagen, and a well-organized fibrin network on the aneurysm neck. In contrast, unhealed aneurysms displayed a poorly organized fibrin network with scattered myofibroblasts at the neck area.

CONCLUSIONS
These findings indicate that fibrin plays a foundational role in the gradual occlusion of aneurysms after flow diverter treatment. Endovascular approaches that enhance fibrin accumulation could potentially improve aneurysm occlusion rates. Further research is needed to establish the precise role of fibrin in aneurysm occlusion.
Development and validation of a novel nomogram for predicting good neoangiogenesis after encephaloduroarteriosynangiosis in patients with moyamoya disease and type 2 diabetes mellitus: a case-control study
Authors: Li Jing-Jie , Ren Bin , Wang Xiao-Peng , Wang Qian-Nan , Bao Xiang-Yang , Guo Qing-Bao , Kong Zi-Qing , Liu Jia-Qi , Gao Gan , Wang Min-Jie , Liu Si-Meng , Fu He-Guan , Tong Huai-Yu , Duan Lian 
Published: May 2024

OBJECTIVE
Diabetes is often linked to poorer outcomes in patients with moyamoya disease (MMD). However, experience has shown that certain individuals with diabetes have favorable outcomes after encephaloduroarteriosynangiosis (EDAS). The authors aimed to develop a nomogram to predict good neoangiogenesis in patients with MMD and type 2 diabetes mellitus (T2DM) to aid neurosurgeons in the identification of suitable candidates for EDAS.

METHODS
Adults with MMD and T2DM who underwent EDAS between June 2004 and December 2018 were included in the analysis. In total, 126 patients (213 hemispheres) with MMD and T2DM from the Fifth Medical Centre of the Chinese PLA General Hospital were included and randomly divided into training (152 hemispheres) and internal validation (61 hemispheres) cohorts at a ratio of 7:3. Univariate logistic and least absolute shrinkage and selection operator regression analyses were used to identify the significant factors associated with good neoangiogenesis, which were used to develop a nomogram. The discrimination, calibration, and clinical utility were assessed.

RESULTS
A total of 213 hemispheres in 126 patients were reviewed, including 152 (71.36%) hemispheres with good postoperative collateral formation and 61 (28.64%) with poor postoperative collateral formation. The authors selected 4 predictors (FGD5 rs11128722, VEGFA rs9472135, Suzuki stage, and internal carotid artery [ICA] moyamoya vessels) for nomogram development. The C-indices of the nomogram in the training and internal validation cohorts were 0.873 and 0.841, respectively. The nomogram exhibited a sensitivity of 84.5% and specificity of 81.0%. The positive and negative predictive values were 92.1% and 66.7%, respectively. The calibration curves indicated high predictive accuracy, and receiver operating characteristic curve analysis showed the superiority of the nomogram. The decision-making analysis validated the fitness and clinical application value of this nomogram. Then a web-based calculator to facilitate clinical application was generated.

CONCLUSIONS
The nomogram developed in this study accurately predicted neoangiogenesis in patients with MMD and T2DM after EDAS and may assist neurosurgeons in identifying suitable candidates for indirect revascularization surgery.
The role of reoperation in pediatric cerebellar pilocytic astrocytoma
Authors: Kameda-Smith Michelle M. , Green Katherine , Hutton Dana L. , Jeelani Noor ul Owase , Thompson Dominic N. P. , Hargrave Darren , Aquilina Kristian 
Published: May 2024

OBJECTIVE
Cerebellar pilocytic astrocytomas (cPAs) in childhood have long been recognized to have a good prognosis after total resection, but the outcome after incomplete resective surgery remains largely unpredictable, with the incidence of radiological progressive disease ranging from 18% to 100%. It has been traditionally thought that gross-total resection was required for long-term survival, and small residuals were classically resected in a subsequent operation.

METHODS
The authors analyzed their pediatric low-grade glioma (PLGG) database for cases treated between 1985 and 2020 and filtered for intracranial PAs, to determine what clinical or radiological factors precipitated revisional resective surgery in their single quaternary care center cohort.

RESULTS
Using the pediatric low-grade glioma database, 283 patients were identified to have a histopathological diagnosis of intracranial PA between 1985 and 2020, of which 200 lesions were within the cerebellum (70.7%). The majority of patients with cPA were between 1 and 10 years of age (n = 145, 72.5%) without gender predominance (M/F = 99:101), usually presenting with 1 lesion (n = 197, 98.5%). Gross-total resection was achieved in 74.5% (n = 149) of initial surgeries for cPA. In patients with subtotal resection, the mean largest diameter of the postoperative residual tumor was 1.06 cm (range 0–2.95 cm). Seven patients with subtotal resection did not require a second resective intervention. In 31 patients the neuro-oncology multidisciplinary team recommended a second resection at a mean time interval of 22.9 months (range 0.13–81.6 months) from the initial surgery. Proportionally, the children who underwent multiple resections were also more likely to receive adjuvant chemo/radiotherapy. Functionally, the children in the multiple operation cohort experienced more complications of therapy including ongoing endocrinopathy, treatment-associated hearing deficit, and neurocognitive deficits.

CONCLUSIONS
Residual disease in cPA should be maintained under clinicocoradiological surveillance postoperatively with adoption of a more conservative approach when residual disease is not significantly changing over time.
Predictive value of different site-specific MRI-based assessments of bone quality for cage subsidence among patients undergoing oblique lumbar interbody fusion
Authors: Zheng Xiao , Tong Tong , Li Wenshuai , Chen Junyi , Zhu Houze , Wang Yunsheng , Wang Linfeng 
Published: May 2024

OBJECTIVE
The aim of this study was to investigate the predictive value of different site-specific MRI-based assessments of bone quality for cage subsidence among patients undergoing oblique lumbar interbody fusion (OLIF) with or without posterior internal fixation.

METHODS
The authors retrospectively reviewed the records of patients who underwent OLIF between 2017 and 2022. Endplate bone quality (EBQ), mean vertebral bone quality (MVBQ), and vertebral bone quality (VBQ) scores were measured using preoperative non–contrast-enhanced T1-weighted MRI of the lumbar spine. Logistic regression analysis was used to identify factors associated with cage subsidence. Receiver operating characteristic curve analysis was used to evaluate the value of different site-specific MRI-based assessments of bone quality in predicting cage subsidence.

RESULTS
Of the 124 patients who underwent OLIF, subsidence was found in 42 (33.9%). The VBQ, MVBQ, and EBQ scores were higher in the subsidence group than in the no-subsidence group. In the stand-alone OLIF (SA-OLIF) group, logistic regression analysis showed that the EBQ score was significantly associated with subsidence (OR 13.656, 95% CI 2.561–72.806; p = 0.002). Furthermore, the areas under the curve (AUCs) for using the VBQ, MVBQ, and EBQ scores and T-score to predict cage subsidence were 0.684, 0.683, 0.745, and 0.685, respectively. In the OLIF with posterior internal fixation (OLIF-PF) group, logistic regression analysis showed that the MVBQ score was significantly associated with subsidence (OR 8.301, 95% CI 2.064–33.385; p = 0.003). The AUCs for using the VBQ score, MVBQ score, and T-score to predict cage subsidence were 0.757, 0.774, and 0.685, respectively.

CONCLUSIONS
There are significant differences in the predictive value of different site-specific bone quality assessments for cage subsidence among patients undergoing OLIF. For SA-OLIF, the EBQ score is recommended, while for OLIF-PF, the VBQ score is preferable.
Variation of practice in the treatment of pyogenic spondylodiscitis: a European Association of Neurosurgical Societies Spine Section study
Authors: Kramer Andreas , G. Thavarajasingam Santhosh , Neuhoff Jonathan , Davies Benjamin M. , Demetriades Andreas K. , Shiban Ehab , Ringel Florian 
Published: May 2024

OBJECTIVE
The incidence of spondylodiscitis is rising across Europe, but the ideal treatment approach remains controversial. The choice between conservative and surgical therapies is ambiguous due to a lack of consensus. This European survey aimed to explore prevailing treatment paradigms for primary spondylodiscitis.

METHODS
Spine neurosurgeons were invited through the European Association of Neurosurgical Societies Spine Section’s mailing list to participate in an online survey featuring 7 spondylodiscitis case vignettes. Along with general management queries, specific patient treatment questions were posed. Data analysis was performed using R software (version 4.0.4). The index of qualitative variation (IQV) was calculated to quantify the variability in responses.

RESULTS
A total of 130 responses were collected, comprising 86.9% board-certified neurosurgeons and 13.1% neurosurgeons in training, with an average of 11 years of practice. Most respondents performed 50–100 spine surgeries annually, with 66.7% specializing in spine surgery. An epidural empyema causing pronounced neurological deficits influenced 95.4% toward a surgical intervention, and mild neurological deficits and challenges in pathogen identification prompted 72.3% and 80%, respectively, to consider a surgical approach. Vertebral body destruction and spinal deformity directed 60% and 66.2%, respectively, toward surgery, whereas advanced age and comorbidities had a much smaller impact—5.4% and 9.2%, respectively. Clinical vignettes highlighted a predominant preference for conservative treatment in specific cases, with statistical significance (p < 0.05). The IQV values evaluated for each question ranged from 0.88 to 0.99, indicating low agreement across all questions among respondents. When examining the average IQV by country, intercountry variations in IQV were substantial, as illustrated by the diverse range of overall mean IQV values (0.15–0.85).

CONCLUSIONS
The findings reveal a significant variability in the treatment of spondylodiscitis among European neurosurgeons, with most neurosurgeons opting for conservative treatment. These diverse strategies, both between and within countries, highlight an imperative for evidence-backed guidelines and consensus statements for this grave condition.
Pengembangan Lembar Kegiatan Siswa Berbasis Metode Penemuan Terbimbing untuk Pembelajaran Matematika pada Siswa Kelas XII SMA Negeri 1 Segeri
Authors: Alam Zam Immawan , Razak Firdha 
Published: May 2024

Penelitian ini adalah penelitian pengembangan (Research and Development) dengan uji coba terbatas yang bertujuan untuk mengembangkan lembar kegiatan siswa matematika berbasis metode penemuan terbimbing. Subjek penelitian ini adalah siswa kelas XII IPS 3 SMA Negeri 1 Segeri dengan jumlah siswa sebanyak 27 orang. Prosedur pengembangan yang digunakan dalam penelitian ini adalah model ADDIE yang meliputi lima tahap, yaitu tahap analisis, tahap desain, tahap pengembangan, dan tahap implementasi dan evaluasi. Lembar Kegiatan Siswa yang dikembangkan dengan metode penemuan terbimbing divalidasi dan mengalami beberapa kali revisi sehingga didapatkan hasil yang layak untuk digunakan. Hasil dari uji coba terbatas menunjukkan bahwa (1) skor rata-rata yang diperoleh siswa pada tes hasil belajar adalah 81,21 dari skor ideal 100 dengan standar deviasi 8,51; (2); banyaknya siswa yang tuntas belajar adalah 25 dari 27 orang (92,59%); (3) aktivitas siswa dalam proses pembelajaran memenuhi kriteria waktu yang ditetapkan; (4) tanggapan siswa terhadap lembar kegiatan siswa dengan metode penemuan terbimbing sangat positif (5) guru mampu mengelolah pembelajaran dengan menggunakan metode penemuan terbimbing dengan skala penilaian sangat baik.
Pengaruh Metode Pembelajaran STAD terhadap Hasil Belajar Matematika pada Siswa Kelas VIII
Authors: Putri Kabita Camelia , Sutriyono  
Published: May 2024

Penelitian tindakan kelas (PTK) ini dilatar belakangi oleh kenyataan bahwa pembelajaran matematika yang diupayakan guru matematika SMP Negeri 3 Karanganyar belum menunjukkan hasil yang memuaskan. Akibatnya hasil belajar matematika pada siswa kelas VIII SMP Negeri 3 Karanganyar belum maksimal. Penelitian bertujuan meningkatkan pengaruh metode pembelajaran STAD pada pembelajaran matematika terhadap hasil belajar siswa kelas VIII pada materi persamaan linear dua variabel. Hasil penelitian dalam dua siklus adalah sebagai berikut: hasil belajar sebelum dilakukan tindakan adalah 18,75 % siswa tuntas belajar dan 81,25% belum tuntas belajar.Setelah dilakukan tindakan I diperoleh hasil belajar 68,75% siswa tuntas belajar dan 31,25% belum tuntas belajar. Hasil belajar pada siklus kedua tindakan adalah 93,75% siswa tuntas belajar dan 6,25 % siswa tidak tuntas belajar. Artinya pemberian tindakan dengan penerapan metode STAD memberikan dampak pada hasil belajar siswa. Kesimpulan penelitian adalah ada pengaruh metode STAD pada pembelajaran matematika terhadap hasil belajar siswa kelas VIII SMP Negeri 3 Karanganyar.
This classroom action research is based on the fact that mathematics learning by mathematics teachers of SMP Negeri 3 Karanganyar has not shown satisfactory results. As a consequence, the results of mathematics learning in grade VIII students at SMP Negeri 3 Karanganyar are not maximized. The study aimed to improve the influence of the STAD learning method on the learning of mathematics on the learning outcomes of students of class VIII on two linear equations. The results of the research in two cycles are as follows: learning outcomes before the action is 18.75% students had completed the learning and 81.25% students had not completed learning. After doing the action I obtained the results of learning 68.75% of students completed the study and 31.25% did not complete learning. Learning outcomes in the second cycle of action are 93.75% of students succeed the learning and 6.25% of students do not complete learning. This means that the provision of action with the application of the STAD method has an impact on student learning outcomes. The research concludes that the effect of the STAD method can be found in the learning of mathematics on the result of the student's learning in grade VIII SMP Negeri 3 Karanganyar.
Teaching Method: The Use of Engage, Study, and Activate (ESA) on Students’ Vocabulary Mastery
Authors: Ishak  
Published: May 2024

The purpose of the research is to investigate whether the Engage, Study, and Activate (ESA) method was effectively used by eighth grade students for vocabulary mastery. The researcher used quantitative approach by the design of this study was quasi-experimental research to determine the effectiveness of the Engage, Study, and Activate (ESA) method on vocabulary mastery. The population of the research consisted of 205 students, and the sample of the research was the eighth grade of SMP Negeri 5 Tangerang for the academic year 2021-2022, which consisted of 60 students. The results of the research showed that the students’ vocabulary in the pre-test and post-test differed significantly, up to 20 percent. After receiving the treatment, their vocabulary significantly improved. This can be seen from the average pre-test results in the experimental class of 61.6 and the average post-test of 74.13. The mean of the pre-test results in the control class was 58.66, and the average post-test results were 64.26. The value of the t-test was greater than the t-table (5.40 > 2.00). It indicated that the alternative hypothesis (H1) was accepted and the null hypothesis (H0) was rejected. It can be concluded that the use of the Engage, Study, and Activate (ESA) method is effective in improving vocabulary mastery.
Monolingual Used on The Historical Sites in Dili, Timor-Leste: A Study of Linguistics Landscape
Authors: Soares Antonio Constantino 
Published: May 2024

Timor-Leste which is further called (TL) is also well-known as a multilingual and multicultural country. Besides, Timor-Leste also has 32 local languages and 3 foreign languages such as Portuguese, Bahasa Indoenesia and English. Portuguese is used as the official language however, Bahasa Indonesia and English are used as working languages. This research aimed to determine and to explore the predominant language used in historical sites in Dili. This is a qualitative research and the data were collected by using taking pictures technique with a mobile phone camera. After all the data were collected then, they were analyzed by using qualitaive descriptive method. The Results in this research showed that there are 6 historical sites found in Dili. Tetum language is used as monolingual to describe and explain the brutal action done by the Indonesian Military during the Indonesian occupation in Timor-Leste.
Design and Development of Bangka District Regional Library Information System Based on Website
Authors: Deva Ronaldo Muhammad , Ananda Putri Chaca , Zaki Muhammad , Firmansyah Dimas , Satria Wicaksana Sanditias , Fauzan Muhammad , Budiarjo Aziz , Tou Nurhaeka 
Published: May 2024

This research aims to overcome the challenges faced by the Bangka Regency Regional Public Library (Perpusda) in the book lending process which is still done manually. Currently, visitors must register as members through a system that can only be accessed on-site with the help of library staff, indicating the need for a more efficient solution in managing library data. Thus, this research aims to develop a website-based library information system that can simplify the process of member registration and book borrowing, as well as improve the efficiency of overall library data management. The system development method used is the Waterfall method, which allows the stages of system development to be carried out in a structured manner, starting from needs analysis, design, implementation, to system testing. The result of this research is the design of a web-based library information system that has been successfully developed. This system has been tested and demonstrated at the Bangka Regency Library, and the results show that the implementation of this system will make a significant contribution in improving the efficiency of library data management. Thus, this library information system is expected to provide great benefits for librarians and library users in accessing and managing information more efficiently.