bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sudden gains versus gradual gains in a psychotherapy training clinic
Authors: Greenfield Michael F. , Gunthert Kathleen C. , Haaga David A.F. 
Published: November 2010

AbstractSudden gains are abrupt and substantial improvements in symptoms. This study used the Outcome Questionnaire‐45 (OQ‐45; Lambert et al., 1996) to characterize sudden gains occurring in a cognitive‐behavioral therapy training clinic. Also, gradual gainers were identified and used as a comparison group. Sudden gains were identified in 23% of patients and in 29% of those who entered treatment in the clinical range on the OQ, within the range of prevalence established by previous sudden gain studies in the context of randomized controlled trials (RCT's). As in earlier research, sudden gains tended to occur early in therapy. However, sudden gains were more likely to be reversed than in RCT's. Gradual gains occurred for 54% of nonsudden gainers; they were of similar magnitude to sudden gains but occurred later in therapy. Sudden gainers showed significantly better outcomes at the end of treatment than did gradual gainers. Sudden gains have clear prognostic significance, but more research is needed to determine why they may be more transient in naturalistic studies or studies involving less experienced therapists than they are in RCT's. © 2010 Wiley Periodicals, Inc. J Clin Psychol 00:1–14, 2010.
Modelling of plastic deformation and damage in cement‐based material subjected to desiccation
Authors: Chen L. , Duveau G. , Shao J. F. 
Published: November 2010

AbstractThe present work is devoted to modelling of plastic deformation and damage in cement‐based materials subjected to desiccation and mechanical loading. Basic mechanical behaviours of cement‐based materials and influences of saturation degree on such behaviours are first recalled. Physical mechanisms of damage induced by desiccation process are analysed. An elastoplastic damage model is then proposed for the description of mechanical responses, taking into account the transition from brittle to ductile behaviours with the increase of confining pressure. The model is further extended to unsaturated conditions: a specific damage driving force and generalized effective stress concept for plastic flow are proposed. The procedure of determination of model's parameters is presented. The proposed model is applied to a standard mortar subjected to desiccation process. The main features of mechanical behaviours as well as the influence of saturation degree are correctly described by the proposed model. In particular, the kinetics of desiccation and related damage evolution are well reproduced. As an example of application, the responses of a concrete beam in three‐point bending test with different desiccation conditions is investigated. Again, the numerical simulations are in good agreement with the experimental data. Copyright © 2010 John Wiley & Sons, Ltd.
Perceptions of “urgency” in women with interstitial cystitis/bladder pain syndrome or overactive bladder
Authors: Clemens J. Quentin , Bogart Laura M. , Liu Karin , Pham Chau , Suttorp Marika , Berry Sandra H. 
Published: November 2010

AbstractPurposeTo compare urgency symptoms in women with interstitial cystitis/bladder pain syndrome (IC/BPS) and overactive bladder (OAB).Materials and MethodsWomen with diagnoses of IC/BPS (n = 194) and OAB (n = 85) were recruited from the clinical practices of Urologists (n = 8) and Gynecologists (n = 16) with recognized expertise in the diagnosis and management of these conditions. Subjects completed a comprehensive telephone survey about their current symptoms. The questionnaire included 11 questions about urinary urgency. Responses were compared between the two groups.ResultsUrgency was commonly reported as a symptom by women with both conditions (81% IC/BPS and 91% OAB). Compared with IC/BPS, urgency in OAB more often resulted in leakage, and was perceived to be more of a problem. In IC/BPS, the urgency was primarily reported as due to pain, pressure, or discomfort, while in OAB the urgency was more commonly due to fear of leakage. However, approximately 40% of women with OAB also report urgency due to pain, pressure, or discomfort. Similar proportions of both groups (∼60%) indicated that the urgency occurred “suddenly” instead of more gradually over a period of minutes or hours.ConclusionsUrgency symptoms differed in women diagnosed with IC/BPS versus those diagnosed with OAB, but there was significant overlap. This suggests that “urgency” is not a well‐defined and commonly understood symptom that can be utilized to clearly discriminate between IC/BPS and OAB. These findings reinforce the clinical observation that it is often challenging to differentiate between these two conditions. Neurourol. Urodynam. 30:402–405, 2011. © 2010 Wiley‐Liss, Inc.
CD34+ immunoselection of autologous grafts for the treatment of high‐risk neuroblastoma
Authors: Marabelle Aurélien , Merlin Etienne , Halle Pascale , Paillard Catherine , Berger Marc , Tchirkov Andrei , Rousseau Raphaël , Leverger Guy , Piguet Christophe , Stephan Jean‐Louis , Demeocq François , Kanold Justyna 
Published: November 2010

AbstractBackgroundGraft contamination has been blamed for causing relapse in children with high‐risk neuroblastoma (HRNB) after autologous hematopoietic stem cell transplantation (HSCT).ProcedureWe report the long‐term results of hematopoietic reconstitution, post‐transplant complications, and clinical outcome of 44 children with HRNB treated with busulfan/melphalan high‐dose chemotherapy followed by transplantation of purged CD34+ immunoselected autologous peripheral HSCT. Minimal residual disease (MRD) of grafts was evaluated by anti‐GD2 immunofluorescence or tyrosine hydroxylase reverse transcriptase‐polymerase chain reaction (RT‐PCR).ResultsContaminating neuroblasts were found in 19/38 grafts (50%) before CD34+ positive selection, and none after (technique sensitivity of one cell in 105). A median of 6.5 × 106 CD34+ cells/kg (range 0.8–23.7) were transplanted with only 2% of TRM. Neutrophils and platelet recovery occurred within a median of 12 days (range 9–47) and 44 days (range 12–259), respectively, without any secondary graft failure. Twenty‐three percents of patients experienced a sepsis (10/44) and 14% a pyelonephritis (6/44). Recurrence of varicella zoster virus occurred in 21% of patients (9/44). Negative RT‐PCR MRD within the leukapheresis product and cis‐retinoic acid therapy were significantly and independently associated to a better survival (P < 0.05). Overall and event‐free survivals at 5 years post‐transplant were at 59.3% and 48.3% respectively.ConclusionsBesides high rates of manageable infections due to late immune recovery, transplantation with CD34+ immunoselected grafts in HRNB children was feasible and did not affect long‐term hematopoiesis. Pediatr Blood Cancer. 2010;56:134–142. © 2010 Wiley‐Liss, Inc.
Argatroban therapy in pediatric patients requiring nonheparin anticoagulation: An open‐label, safety, efficacy, and pharmacokinetic study
Authors: Young G. , Boshkov L.K. , Sullivan J.E. , Raffini L.J. , Cox D.S. , Boyle D.A. , Kallender H. , Tarka E.A. , Soffer J. , Hursting M.J. 
Published: November 2010

AbstractBackgroundAn increasing number of pediatric patients suffer from thrombotic events necessitating anticoagulation therapy including heparins. Some such patients develop heparin‐induced thrombocytopenia (HIT) and thus require alternative anticoagulation. As such, studies evaluating the safety, efficacy, and dosing of alternative anticoagulants are required.ProcedureIn this multicenter, single arm, open‐label study, 18 patients ≤16 years old received argatroban for either a suspicion of or being at risk for HIT, or other conditions requiring nonheparin anticoagulation. Endpoints included thrombosis, thromboembolic complications, and bleeding.ResultsPatients (ages, 1.6 weeks to 16 years) received argatroban usually for continuous anticoagulation (n = 13) or cardiac catheterization (n = 4). One catheterization patient received a 250 µg/kg bolus only; 17 patients received argatroban continuous infusion (median (range)) 1.1 (0.3–12) µg/kg/min (of whom four received a bolus) for 3.0 (0.1–13.8) days. In patients without bolus dosing, typically argatroban 1 µg/kg/min was initiated, with therapeutic activated partial thromboplastin times (aPTTs) (1.5–3× baseline) achieved within 7 hr. Within 30 days, thrombosis occurred in five patients (two during therapy). No one required amputation or died due to thrombosis during therapy. Two patients had major bleeding. Pharmacometric analyses demonstrated the optimal initial argatroban dose to be 0.75 µg/kg/min (if normal hepatic function), with dose reduction necessary in hepatic impairment.ConclusionsIn pediatric patients requiring nonheparin anticoagulation, argatroban rapidly provides adequate levels of anticoagulation and is generally well tolerated. For continuous anticoagulation, argatroban 0.75 µg/kg/min (0.2 µg/kg/min in hepatic impairment), adjusted to achieve therapeutic aPTTs, is recommended. Pediatr Blood Cancer 2011;56:1103–1109. © 2010 Wiley‐Liss, Inc.
Mucoepidermoid carcinoma of the lung arising at the primary site of a bronchogenic cyst: Clinical, cytogenetic, and molecular findings
Authors: Brassesco María Sol , Valera Elvis Terci , Lira Régia Caroline Peixoto , Torres Lídia Alice Gomes M. , Scrideli Carlos Alberto , Elias Jorge , Teixeira Sara Reis , Tone Luiz Gonzaga 
Published: November 2010

AbstractPrimary lung tumors are rare in children, and mucoepidermoid carcinoma (MEC) represents less than 10% of them. Additionally, MEC arising from bronchogenic cysts (BC) is particularly unusual. We describe the clinical and genetic findings on a MEC occurring within a previous location of a BC in an adolescent. This particular association has not been previously reported. The lesion revealed normal karyotype without the typical t(11;19)(q21;p13) translocation. Cyclin D1 overexpression (165‐fold increase) was demonstrated by real‐time PCR although FISH assessment showed normal hybridization at 11q13. Information on these unusual clinical presentations may present relevant insight on tumorigenesis of infrequent pediatric pulmonary tumors. Pediatr Blood Cancer 2011;56:311–313. © 2010 Wiley‐Liss, Inc.
Proteome profile of whole cerebellum of the mature rat
Authors: Maurya Devendra Kumar , Sundaram Curam Sreenivasacharlu , Bhargava Purnima 
Published: November 2010

AbstractCerebellum is an important brain region involved in motor, cognition, learning and memory functions. Proteome mapping of the 21 days old rat cerebellum identified total 285 proteins, out of which 76 proteins were not reported earlier from rat brain. This includes 49 neuronal activity‐specific proteins, 7 of which are reported for the first time from the cerebellum in this study. The protein sequence data for 31 proteins reported here have been integrated in the UniProt Knowledgebase.
High‐Pressure Vibrational Spectroscopy of Hexahydro‐ 1,3,5‐Trinitro‐1,3,5‐Triazine (RDX)
Authors: Zheng Xianxu , Zhao Jun , Tan Duowang , Liu Cangli , Song Yunfei , Yang Yanqiang 
Published: November 2010

AbstractThe molecular‐level response of RDX to hydrostatic compression was examined in a diamond anvil cell using Raman spectroscopy. The pressure‐induced alterations in spectral profiles of the CN stretching mode (886 cm−1) were studied up to 8.3 GPa. At pressures near 4.4 GPa, several changes of the CN stretching mode become immediately apparent in Raman spectrum, such as large frequency shifts, line broadening, mode splitting, and intensity changes, which are associated with the α–γ phase transition and rearrangement between the RDX molecules. The high pressure Raman spectra changes of the CN stretching mode are indicative of an α–γ phase transition, and also suggest the lowering of molecular symmetry and crystal symmetry, which are expected to provide some insight into RDX molecular stability and decomposition.
A miniaturized technique for assessing protein thermodynamics and function using fast determination of quantitative cysteine reactivity
Authors: Isom Daniel G. , Marguet Philippe R. , Oas Terrence G. , Hellinga Homme W. 
Published: November 2010

AbstractProtein thermodynamic stability is a fundamental physical characteristic that determines biological function. Furthermore, alteration of thermodynamic stability by macromolecular interactions or biochemical modifications is a powerful tool for assessing the relationship between protein structure, stability, and biological function. High‐throughput approaches for quantifying protein stability are beginning to emerge that enable thermodynamic measurements on small amounts of material, in short periods of time, and using readily accessible instrumentation. Here we present such a method, fast quantitative cysteine reactivity, which exploits the linkage between protein stability, sidechain protection by protein structure, and structural dynamics to characterize the thermodynamic and kinetic properties of proteins. In this approach, the reaction of a protected cysteine and thiol‐reactive fluorogenic indicator is monitored over a gradient of temperatures after a short incubation time. These labeling data can be used to determine the midpoint of thermal unfolding, measure the temperature dependence of protein stability, quantify ligand‐binding affinity, and, under certain conditions, estimate folding rate constants. Here, we demonstrate the fQCR method by characterizing these thermodynamic and kinetic properties for variants of Staphylococcal nuclease and E. coli ribose‐binding protein engineered to contain single, protected cysteines. These straightforward, information‐rich experiments are likely to find applications in protein engineering and functional genomics. Proteins 2011. © 2010 Wiley‐Liss, Inc.
Pulmonary immune memory: localized production of antibody in the lung after antigen challenge
Authors: BICE D. E. , MUGGENBURG B. A. 
Published: November 2010

SummaryIn comparison to primary immune responses after lung immunization, the level of antigen‐specific antibody and the number of cells producing specific antibody are significantly increased after challenging the lungs with antigen. The response of immune memory cells in the lung to an antigen challenge could be responsible for this elevated immune response. However, increased numbers of antibody‐producing cells, possibly produced in the lung‐associated lymph nodes, are also found in the blood after an antigen challenge. Therefore, it is possible that both the response of immune memory cells in the lung, and the recruitment of antibody‐producing cells from the blood, contribute to the elevated levels of antibody in the lung after an antigen challenge. This study compared the level of antibody produced in the lung by the response of pulmonary immune memory cells with the level of antibody produced by antibody‐forming cells that enter the lung from blood after an antigen challenge. This comparison was made possible by immunizing and challenging two lung lobes of dogs with two antigens. The immune responses to both antigens were then evaluated in both lung lobes after primary immunization and challenge. Data from these evaluations showed that most antibody in the lung after an antigen challenge is produced by a localized anamnestic response of pulmonary immune memory cells. A significantly lower level of antibody entered the lung from the vasculature and/or was produced by antibody‐forming cells that entered the lung from blood after an antigen challenge.
Influence of soaking on the nutritional quality of common beans (Phaseolus vulgaris L.) cooked with or without the soaking water: a review
Authors: Fernandes Ana Carolina , Nishida Waleska , Da Costa Proença Rossana P. 
Published: November 2010

SummaryBean soaking seems to be unanimously recommended by scientists; however, there is no consensus regarding the need to discard the soaking water before cooking. Thus, the present study proposes to review the influence of maceration on the nutritional quality of common beans (Phaseolus vulgaris L.) cooked with or without the soaking water, in an attempt to achieve agreement among scientists. The article search was done in a systematic way and eleven studies were found. Of these, three compared the use or not of the soaking water for cooking, seven of them discarded the soaking water and one used the soaking water. This review discusses each nutrient and antinutrient regarding the effects of soaking and compares them with other studies done with legumes. The results were not unanimous but there was a greater advantage to discarding the soaking water before cooking.
Phenolic compounds from winemaking waste and its antioxidant activity towards oxidation of rapeseed oil
Authors: Mildner‐Szkudlarz Sylwia , Zawirska‐Wojtasiak Renata , Gośliński Michał 
Published: November 2010

SummaryThe effects of extraction parameters on bioactive compound contents of winemaking waste extracts (WWE) and its effect on rapeseed oil oxidative stability were evaluated. Research showed that the total phenols and anthocyanin contents and antioxidant activity (AA) of WWE significantly depended on the extraction parameters. Increasing the temperature (60 °C) and time (5 h) of extraction and an addition of water to ethanol statistically improved the rate of active component extraction. HPLC analysis showed that procyanidin B2, catechin, gallic acid, γ‐resorcylic acid and p‐coumaric acid were the major phenolic compounds of WWE. Important correlations between total phenolic compounds quantified by HPLC and both DPPH and (ferric reducing antioxidant power) (FRAP) values were found. WWE added to the oil at three different levels clearly slowed down the process of fatty acid oxidation, inhibiting hydroperoxide formation by about 86%, comparable with BHT, while it was more effective than that of α‐tocopherol. When using volatile compound formation as a marker of lipid oxidation, WWE at the level of 2000 ppm were the most effective inhibitors of the decomposition of hydroperoxides. The research showed that the WWE are a rich source of phenolic compounds with powerful antioxidant activities and are suitable for preventing rapeseed oil oxidation.
Old and endangered tomato cultivars under organic greenhouse production: effect of harvest time on flavour profile and consumer acceptance
Authors: Klein Daniela , Gkisakis Vasileios , Krumbein Angelika , Livieratos Ioannis , Köpke Ulrich 
Published: November 2010

SummaryThe influence of two different harvest times (optimal and 4 days earlier) on thirty flavour compounds, titratable acid and sugars as well as consumer acceptance of four old and endangered tomato cultivars (‘Ananas’, ‘Auriga’, ‘Green Zebra’ and ‘Lukullus’) was analysed. In most cases, cultivar type had a greater effect on the volatiles profile than harvest times. Sugar contents were mostly higher at optimal harvest compared with early harvest, whereas acid content was in most cases not affected by harvest time. Consumers perceived differences in several visual and sensory aspects between cultivars as well as harvest times. The optimal harvest was regularly preferred to or at least regarded as equal to the early‐harvest time. Sensory evaluation was poorly related to the aroma volatile profile and only partly to the acid and reducing sugar contents of tomatoes. This was probably owing to the special external characteristics of the tomatoes: differing in size, shape and colour from the ‘normal’ red types.
Effect of hexanal vapour on longan fruit decay, quality and phenolic metabolism during cold storage
Authors: Thavong Porntip , Archbold Douglas D. , Pankasemsuk Tanachai , Koslanund Rumphan 
Published: November 2010

SummaryThe effects of postharvest treatment with hexanal vapour on longan fruit decay, quality, hexanal residue, phenolic compound content, and polyphenoloxidase (PPO) and peroxidase (POD) activities were studied during storage at 5 °C for 30 days. Hexanal exposure for 2 h at 900 μL L−1 before cold storage reduced the percentage of fruit with decay and was deemed the optimum treatment. Hexanal exposure resulted in a pericarp that was more reddish brown and less intense in colour. Hexanal residue in the pericarp and aril of fumigated fruit was several fold higher than that of nonfumigated fruit, although levels were low at the end of cold storage. Electrolyte leakage of pericarp increased during 5 °C storage and was further increased by hexanal exposure. Hexanal reduced pericarp phenolic content, and increased PPO and POD activities. Overall, use of hexanal vapour reduced postharvest disease of longan fruit but increased the likelihood of pericarp browning.
Lipid stability in powdered infant formula stored at ambient temperatures
Authors: Carmen García‐Martínez María del , Rodríguez‐Alcalá Luis M. , Marmesat Susana , Alonso Leocadio , Fontecha Javier , Márquez‐Ruiz Gloria 
Published: November 2010

SummaryLipid stability of standard infant formula was evaluated at ambient temperatures, namely 25, 30 and 37 °C, during 3 months. Lipids were thoroughly analysed to evaluate changes in fatty acid composition and trans fatty acid isomers, non‐volatile oxidation compounds including oxidised, dimeric and polymeric triacylglycerols, and tocopherol. No significant changes in either of the parameters examined were found in total lipids extracted from infant formula along the storage period. However, the minor free oil fractions (about 7.5% of total lipids) showed a significant increase in oxidation compounds and marked decrease in tocopherol levels during storage at all temperatures. Samples stored at 37 °C for 3 months were rancid and, accordingly, contained the highest oxidation level in the free oil fraction, whereas total lipids extracted were apparently not oxidised. Results showed the necessity of analysing separately the free oil fraction in infant formulae to obtain a clear picture of the oxidation status.
Mass transfer kinetics during osmotic dehydration of bananas (Musa sapientum, shum.)
Authors: Mercali Giovana D. , Tessaro Isabel C. , Noreña Caciano P. Z. , Marczak Lígia D. F. 
Published: November 2010

SummaryOsmotic dehydration is used widely to partially remove water from plant tissues by immersion in a hypertonic solution. In this work, the influence of temperature (25–55 °C), sugar concentration (30–60%) and salt concentration (0–10%) of the osmotic solution was investigated during osmotic dehydration of banana (Musa sapientum, shum.). Mass transfer kinetics were modelled according to Peleg’s equation. Kinetic parameters were evaluated using response surface methodology. Peleg’s equation showed to be suitable for modelling the water removal and solute uptake. Initial rate of water loss and water concentration at equilibrium were influenced by linear factors of the three independent variables. Initial rate of sucrose uptake and sucrose uptake at equilibrium were affected by all factors and interactions. Initial rate of salt uptake and salt concentration at equilibrium showed a positive correlation with temperature and NaCl concentration and a negative correlation with sucrose concentration.
Changes in aroma profile of sherry wines during the oxidative ageing
Authors: Zea Luis , Moyano Lourdes , Medina Manuel 
Published: November 2010

SummaryThe aroma of Oloroso sherry wines produced by industrial oxidative ageing for 0, 3, 6, 9 and 14 years was studied by gas chromatography‐olfactometry analysis. Eighteen compounds with odour activity values (OAVs) > 1 and detected by sniff were classified according to their odour descriptors into eight odorant series (fruity, chemical, balsamic, vegetable, fatty, empyreumatic, floral and spicy) describing the aroma profile of the studied wines. The fruity and vegetable series showed the highest and lowest OAVs, respectively, during ageing, being the fruity, chemical and balsamic series those best discriminating the aroma of wines of different ageing time. The ethyl esters plus acetaldehyde and its derivatives (related to the chemical reactivity of ethanol) increased their contribution in a higher proportion than those not synthesised from this alcohol (non‐ethyl esters, alcohols and compounds from cask wood) during the ageing process.