bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prevalence, Characteristics, and In-Hospital Outcomes of Metabolic Syndrome among Patients with Acute Coronary Syndrome in the United Arab Emirates
Authors: Shehab Abdulla , Al-Dabbagh Bayan , Almahmeed Wael , Bustani Nazar , Nagelkerke Nicolaas , Alnaeemi Abdulla , Alsheikh-Ali Alawi A 
Published: July 2012

Objective:
To evaluate clinical profiles, management and in-hospital outcomes of acute coronary syndrome (ACS) patients with metabolic syndrome (MetS) in the United Arab Emirates (UAE).

Methods:
MetS was defined according to the criteria for its diagnosis by the International Diabetes Federation (IDF) and the American Heart Association/National Heart, Lung and Blood Institute (AHA/NHLBI). Participants were admitted to various hospitals in the UAE with a diagnosis of ACS in 2007 as part of the Gulf Registry of Acute Coronary Events (Gulf RACE) project. We compared baseline characteristics, treatment patterns, and in-hospital outcomes stratified by MetS status.

Results:
Of 1259 patients with ACS in the UAE (mean age: 52 ± 11 years, 88.8% males), the majority (n = 851, 67.6%) had MetS. MetS patients were more frequently males (86.4 vs 13.6%; P < 0.001). They were more obese (waist circumference and BMI, P < 0.001) as compared with non-MetS patients. MetS was more frequently associated with hypertension (51.1 vs 37.7%; P < 0.001) and diabetes mellitus (45.6 vs 24.3%; P < 0.001). After multivariate adjustment, certain MetS criteria rather than MetS itself were associated with higher in-hospital mortality and heart failure. Paradoxically, hypertension was associated with lower in-hospital mortality.

Conclusions:
Prevalence of MetS among patients with ACS in our study population was high. Certain MetS criteria were associated with higher in-hospital mortality and heart failure.
Monitoring Quality of Care at Dialysis Facilities
Authors: Stivelman John C. 
Published: July 2012

Summary
With the issuance of the new Conditions for Coverage in 2008 and the implementation of the Prospective Payment System in 2011, the Centers for Medicare & Medicaid Services has fundamentally altered the regulatory landscape of quality in the ESRD program. Although these changes—largely through use of tools comparing individual facility performance to regional and national quality expectations—have increased facility accountability for the quality of patient care in many quarters, they have also complicated both substance and process of facility adherence to quality rules in that component of the program. This editorial critically assesses the main quality tools now in use for dialysis facilities and reviews the issues arising from their conjoint use. A scheme for improving the effectiveness of each quality tool is proposed, and an assessment of their future value and effectiveness in quality improvement is offered.
Short- and Long-Term Mortality After Myocardial Infarction in Patients With and Without Diabetes
Authors: Nauta Sjoerd T. , Deckers Jaap W. , Akkerhuis K. Martijn , van Domburg Ron T. 
Published: July 2012

OBJECTIVE
To study temporal trends in short- and long-term outcome after myocardial infarction (MI) according to diabetes status.

RESEARCH DESIGN AND METHODS
We included all 14,434 consecutive patients admitted for ST-segment elevation MI or non–ST-segment elevation MI at our center between 1985 and 2008. The study patients were compared according to prevalent diabetes. Temporal trend analyses were performed by comparing decades of admission (1985–1989 vs. 1990–1999 vs. 2000–2008).

RESULTS
A total of 2,015 (14%) of the patients had prevalent diabetes. The risk of presenting with diabetes increased from 8 to 17% from 1985 to 2008. Diabetic patients presented with a higher prevalence of cardiovascular risk factors. With time, the use of evidence-based therapies increased in both patients with and without diabetes. Diabetes is associated with a 1.5-fold increased risk of mortality at the 20-year follow-up. Ten-year mortality decreased over time in patients with diabetes, from 53% in 1985–1989 to 39% in 2000–2008 (adjusted hazard ratio 0.56 [95% CI 0.43–0.73]), and in those without diabetes, from 38% in 1985–1989 to 29% in 2000–2008 (0.66 [0.60–0.73]; P interaction = 0.83). Patients with diabetes benefitted from a higher 30-day and 10-year absolute survival increase.

CONCLUSIONS
Temporal mortality reductions after MI between 1985 and 2008 were at least as high in patients with diabetes compared with those without diabetes. However, long-term mortality remained higher in diabetic patients. Awareness of the high-risk profile of diabetic patients is warranted and might stimulate optimal medical care and outcome.
Long-Term Prognosis of Diabetic Foot Patients and Their Limbs
Authors: Morbach Stephan , Furchert Heike , Gröblinghoff Ute , Hoffmeier Heribert , Kersten Kerstin , Klauke Gerd-Thomas , Klemp Ulrike , Roden Thomas , Icks Andrea , Haastert Burkhard , Rümenapf Gerhard , Abbas Zulfiqarali G. , Bharara Manish , Armstrong David G. 
Published: July 2012

OBJECTIVE
There is a dearth of long-term data regarding patient and limb survival in patients with diabetic foot ulcers (DFUs). The purpose of our study was therefore to prospectively investigate the limb and person survival of DFU patients during a follow-up period of more than 10 years.

RESEARCH DESIGN AND METHODS
Two hundred forty-seven patients with DFUs and without previous major amputation consecutively presenting to a single diabetes center between June 1998 and December 1999 were included in this study and followed up until May 2011. Mean patient age was 68.8 ± 10.9 years, 58.7% were male, and 55.5% had peripheral arterial disease (PAD). Times to first major amputation and to death were analyzed with Kaplan-Meier curves and Cox multiple regression.

RESULTS
A first major amputation occurred in 38 patients (15.4%) during follow-up. All but one of these patients had evidence of PAD at inclusion in the study, and 51.4% had severe PAD [ankle-brachial pressure index ≤0.4]). Age (hazard ratio [HR] per year, 1.05 [95% CI, 1.01–1.10]), being on dialysis (3.51 [1.02–12.07]), and PAD (35.34 [4.81–259.79]) were significant predictors for first major amputation. Cumulative mortalities at years 1, 3, 5, and 10 were 15.4, 33.1, 45.8, and 70.4%, respectively. Significant predictors for death were age (HR per year, 1.08 [95% CI, 1.06–1.10]), male sex ([1.18–2.32]), chronic renal insufficiency (1.83 [1.25–2.66]), dialysis (6.43 [3.14–13.16]), and PAD (1.44 [1.05–1.98]).

CONCLUSIONS
Although long-term limb salvage in this modern series of diabetic foot patients is favorable, long-term survival remains poor, especially among patients with PAD or renal insufficiency.
Cytostatic and cytotoxic properties of monensic acid and its biometal(II) complexes against human tumor / non-tumor cell lines
Authors: Alexandrova Radostina , Zhivkova Tanya , Alexandrov Marin , Miloshev Georgi , Georgieva Milena , Pantcheva Ivayla , Mitewa Mariana 
Published: July 2012

Abstract
The anticancer activity of monensic acid (MonH) and its biometal(II) complexes [M(Mon)2(H2O)2](M = Mg, Ca, Mn, Co, Ni, Zn) was evaluated against cultured human permanent cell lines established from glioblastoma multiforme (8MGBA) and cancers of the lung (A549), breast (MCF-7), uterine cervix (HeLa) and liver (HepG2). The viability and proliferation of the non-tumor human embryonic cell line Lep3 was also tested. The investigations were carried out using a thiazolyl blue tetrazolium bromide test, neutral red uptake cytotoxicity assay, crystal violet staining, colony forming method and double staining with acridin orange and propidium iodide. The results obtained reveal that the compounds applied at concentrations of 0.5–25 µg mL−1 for 24–72 h decrease the viability and proliferation of the treated cells in a time- and concentration-dependent manner. The metal(II) complexes studied (especially those of Co(II), Ni(II) and Zn(II)) have been found to express stronger cytotoxic and cytostatic activities than the non-coordinated monensic acid. The non-tumor human cell line showed strong chemosensitivity towards compounds tested comparable to that of cultured human tumor cell lines.
Sequential extraction and thermal desorption of mercury from contaminated soil and tailings from Mongolia
Authors: Coufalík Pavel , Krásenský Pavel , Dosbaba Marek , Komárek Josef 
Published: July 2012

Abstract
Mercury forms in contaminated environmental samples were studied by means of sequential extraction and thermal desorption from the solid phase. The sequential extraction procedure involved the following fractions: water soluble mercury, mercury extracted in acidic conditions, mercury bound to humic substances, elemental Hg and mercury bound to complexes, HgS, and residual mercury. In addition to sequential extraction, the distribution of mercury species as a function of soil particles size was studied. The thermal desorption method is based on the thermal decomposition or desorption of Hg compounds at different temperatures. The following four species were observed: Hg0, HgCl2, HgS and Hg(II) bound to humic acids. The Hg release curves from artificial soils and real samples were obtained and their applicability to the speciation analysis was considered.
Role of water in determining organic reactivity in aqueous binary solvents
Authors: Salmar Siim , Järv Jaak , Tenno Tiina , Tuulmets Ants 
Published: July 2012

Abstract
Kinetic data for organic reactions in various binary water-organic solvent mixtures were collected and quantitatively analysed in terms of linear-free-energy relationships by using tert-butyl chloride (2-chloro-2-methylpropane) solvolysis as the reference system. Linear similarity plots for these kinetic data were determined for solvent systems ranging from pure water mixtures up to considerable amount of cosolvent, and 161 similarity coefficients were calculated from slopes of these plots. The existence of these linear plots demonstrated that the solvent effects are of some common nature in all analysed reaction mixtures independent of the reaction type and the cosolvent used. Therefore it was concluded that the observed effects could be connected to the specific solvating properties of water, which govern reactivity even in significant dilution of water by an organic cosolvent. This conclusion was supported by the linear interrelationship between the slopes of similarity plots of different reactions, and hydrophobicity parameters log P of the reacting compounds. The relative solvent effects observed in binary water-organic solvent mixtures were for the first time directly related to the structure of reacting compounds.
Photometric determination of aqueous cobalt (II), nickel (II), copper (II) and iron (III) with 1-nitroso-2-naphthol-3,6-disulfonic acid disodium salt in gelatin films
Authors: Reshetnyak Elena , Ivchenko Nataliia , Nikitina Nataliya 
Published: July 2012

Abstract
Photometric determination of aqueous Co(II), Cu(II), Ni(II) and Fe(III) was performed using indicator films prepared by immobilization of 1-nitroso-2-naphthol-3,6-disulfonic acid disodium salt (NRS) into hardened photographic film. Immobilization was based on electrostatic interaction of reagent and metal complexes with the gelatin. The isoelectric point pH of hardened gelatin (4.46±0.04) was evaluated by viscometry. Co(II), Fe(III), Ni(II) form 1:3 complexes with NRS in gelatin at pH 2 and Cu(II) forms 1:2 complexes. Their log β′ values were: Co-6.7, Fe-8.6, Cu-8.0, and Ni-6.4. The absorption maxima were: 370nm for NRS, and 430nm, 470nm, 495nm and 720nm for complexes of Co(II), Ni(II), Cu(II) and Fe(III). An algorithm for their simultaneous determination using the indicator films was developed. The detection limits were: clim(Co2+) = 0.45×10−5 M, clim(Fe3+) = 0.50×10−5 M, clim(Cu2+) = 0.67×10−5 M, clim(Ni2+) = 0.75×10−5 M,; and their sum clim(ΣMn+) = 0.82×10−5 M.
Comparison of structure, logP and P388 cytotoxicity of some phenyl and ferrocenyl cyclic chalcone analogues. Application of RP-TLC for logP determination of the ferrocenyl analogues
Authors: Perjési Pál , Takács-Novák Krisztina , Rozmer Zsuzsanna , Sohár Pál , Bozak Richard , Allen Theresa 
Published: July 2012

Abstract
Cyclic chalcone analogues (2–5) and their ferrocenyl counterparts (6–10) were synthesized and their logP and P388 cyctotoxity were investigated. The structures of the newly synthesized compounds were confirmed by IR 1H and 13NMR spectroscopy. Comparison of conjugation and stereochemistry of the respective derivatives showed similar characteristics compared to ones with some higher degree of conjugation in the ferrocenyl series. Comparison of logP of the ferrocenyl derivatives determined by a validated RP-TLC method showed the ferrocenyl derivatives to have higher logP TLC. The results demonstrate that the differences in three dimensional shape, conjugation and lipophilicity do not have strong influence on the P388 cytotoxicity of the investigated phenyl (1−5) and ferrocenyl (6−10) enones.
The structure of plane graphs with independent crossings and its applications to coloring problems
Authors: Zhang Xin , Liu Guizhen 
Published: July 2012

Abstract
If a graph G has a drawing in the plane in such a way that every two crossings are independent, then we call G a plane graph with independent crossings or IC-planar graph for short. In this paper, the structure of IC-planar graphs with minimum degree at least two or three is studied. By applying their structural results, we prove that the edge chromatic number of G is Δ if Δ ≥ 8, the list edge (resp. list total) chromatic number of G is Δ (resp. Δ + 1) if Δ ≥ 14 and the linear arboricity of G is ℈Δ/2⌊ if Δ ≥ 17, where G is an IC-planar graph and Δ is the maximum degree of G.
Atom number calibration in absorption imaging at very small atom numbers
Authors: Konstantinidis Gregory , Pappa Melina , Wikström Gustav , Condylis Paul , Sahagun Daniel , Baker Mark , Morizot Olivier , Klitzing Wolf 
Published: July 2012

Abstract
Cold atom experiments often use images of the atom clouds as their exclusive source of experimental information. The most commonly used technique is absorption imaging, which provides accurate information about the shapes of the atom clouds, but requires care when seeking the absolute atom number for small atom samples. In this paper, we present an independent, absolute calibration of the atom numbers. We directly compare the atom number detected using dark-ground imaging to the one observed by fluorescence imaging of the same atoms in a magneto-optical trap. We normalise the signal using single-atom resolved fluorescence imaging. In order to be able to image the absorption of the very low atom numbers involved, we use diffractive dark-ground imaging as a novel, ultra-sensitive method of in situ imaging for untrapped atom clouds down to only 100 atoms. We demonstrate that the Doppler shift due to the acceleration of the atoms by the probe beam has to be taken into account when measuring the atom-number.
Persistence of conduct disorders and their relation to early initiation of smoking and alcohol drinking in a prospective ELSPAC Study
Authors: Hrubá Drahoslava , Kukla Lubomír , Okrajek Petr , Peřina Aleš 
Published: July 2012

Abstract
The important risk factors of early initiation of smoking and alcohol drinking are: prosmoking family and peers, conduct disorders and delinquency, poor academic performance. The data obtained by physicians, teachers and children were collected at the age of 11 years. Children were divided into group A (without symptoms), Group B (with one or more symptoms). For statistic analysis, the programme EPI INFO was used.During the period between 7 and 11 years, new children with problematic behaviour (178=3.9%) were diagnosed in Group A, while substantial decreasing of children previously included in Group B was seen (by 59.1%). Together 7.05% of 11 years old children visited specialists (psychologists) due to their conduct disorders: 6.8% from Group A and 12.3% from Group B. Children more often than their teachers reported the frequent occurrence of conduct disorder. About 20% of children smoked, and more than 40% had tasted alcohol. However, the differences between Groups A and B were not significant. Our prospective study has demonstrated the possibility of misinterpretation of behavioural outputs. Children with previous behavioural problems had not a higher risk for early smoking and alcohol use.
Intelligent Data Analysis to Model and Understand Live Cell Time-lapse Sequences
Authors: Paterson A. , Ashtari M. , Ribé D. , Stenbeck G. , Tucker A. 
Published: July 2012

SummaryBackground: One important aspect of cellular function, which is at the basis of tissue homeostasis, is the delivery of proteins to their correct destinations. Significant advances in live cell microscopy have allowed tracking of these pathways by following the dynamics of fluorescently labelled proteins in living cells.Objectives: This paper explores intelligent data analysis techniques to model the dynamic behavior of proteins in living cells as well as to classify different experimental conditions.Methods: We use a combination of decision tree classification and hidden Markov models. In particular, we introduce a novel approach to “align” hidden Markov models so that hidden states from different models can be cross-compared.Results: Our models capture the dynamics of two experimental conditions accurately with a stable hidden state for control data and multiple (less stable) states for the experimental data recapitulating the behaviour of particle trajectories within live cell time-lapse data.Conclusions: In addition to having successfully developed an automated framework for the classification of protein transport dynamics from live cell time-lapse data our model allows us to understand the dynamics of a complex trafficking pathway in living cells in culture.
Early Illness Recognition Using In-home Monitoring Sensors and Multiple Instance Learning
Authors: Mahnot A. , Popescu M. 
Published: July 2012

SummaryBackground: Many older adults in the US prefer to live independently for as long as they are able, despite the onset of conditions such as frailty and dementia. Solutions are needed to enable independent living, while enhancing safety and peace of mind for their families. Elderly patients are particularly at-risk for late assessment of cognitive changes.Objectives: We predict early signs of illness in older adults by using the data generated by a continuous, unobtrusive nursing home monitoring system.Methods: We describe the possibility of employing a multiple instance learning (MIL) framework for early illness detection. The MIL framework is suitable for training classifiers when the available data presents temporal or location uncertainties.Results: We provide experiments on three datasets that prove the utility of the MIL framework. We first tuned our algorithms on a set of 200 normal/abnormal behavior patterns produced by a dedicated simulator. We then conducted two retrospective studies on residents from the Tiger Place aging in place facility, aged over 70, which have been monitored with motion and bed sensors for over two years. The presence or absence of the illness was manually assessed based on the nursing visit reports.Conclusions: The use of simulated sensor data proved to be very useful for algorithm development and testing. The results obtained using MIL for six Tiger Place residents, an average area under the receiver operator characteristic curve (AROC) of 0.7, are promising. However, more sophisticated MIL classifiers are needed to improve the performance.
Les Théories Sexuelles Infantiles à travers les âges : du mythe de la cigogne à celui de la petite graine
Authors: Prat Régine 
Published: July 2012

La prise en considération des théories que fabriquent les enfants, semblant ignorer l’explication anatomique qui leur a été donnée, nous conduit à re-envisager le point de vue freudien. Quelle est l’utilité de la production de théories personnelles, prenant la valeur d’élaboration d’un mythe dans un processus de pensée créatif ?
D'où vient la réalité psychique ?
Authors: Martens Francis 
Published: July 2012

L’image de la psychanalyse est associée au « complexe d’Œdipe » considéré comme le noyau fondamental de la sexualité des enfants. Théoriquement, l’abandon par Freud de la théorie d’une séduction réelle des futurs hystériques par des adultes pervers, au profit de celle d’une « réalité psychique » traumatisante tissée de fantasmes inconscients, est l’acte de naissance de la métapsychologie psychanalytique. De fait, l’Œdipe est une structure organisatrice qui vient contenir la sexualité infantile plus qu’il n’en marque l’apogée. Par-delà des réticences d’ordre auto-analytique, Freud n’a jamais véritablement abandonné la théorie de la séduction. L’examen rigoureux qu’en fait Laplanche permet de ne rabattre la sexualité infantile ni du côté de la biologie, ni de celui de la mythologie, mais de donner sa place spécifique à la notion de « réalité psychique ».
Une sexualité infantile polymorphe dans tous ses états : Sombre printemps d'Unica Zürn
Authors: Turki de Ponfilly Rim 
Published: July 2012

Sombre printemps, d’Unica Zürn, est l’étonnant tableau d’une sexualité infantile perverse polymorphe qui parvient à transformer son aspect traumatique grâce à la « création ». Elle fait de cette dernière non seulement le moyen de plaisirs sexuels supplémentaires, mais aussi, un outil de « dépassement » du trauma.
Internet, sociétés civiles et gouvernements : cohabitation ou choc des cultures ?
Authors: Kleinwächter Wolfgang , Granet-Cornée Coline 
Published: July 2012

La gouvernance d’Internet fera l’objet de débats majeurs dans les prochaines années. Poursuivra-t-on sur la voie d’un Internet libre et ouvert ou s’orientera-t-on vers un Internet réglementé par les politiques nationales ou les intérêts économiques ? Il faut inventer des relations neuves entre institutions publiques et acteurs de la société civile, relations de collaboration et non hiérarchisées. À ce prix seulement, Internet pourra progresser pour l’ensemble de la communauté mondiale.
Asie : une reconfiguration géopolitique
Authors: Buzan Barry , Despréaux Claire 
Published: July 2012

Le « supercomplexe » asiatique a pris forme : on le voit à travers le modèle d’adhésion croisée aux organisations intergouvernementales asiatiques et avec l’apparition de politiques de contrepoids à la Chine, en particulier en Inde. L’engagement des États-Unis en Asie de l’Est et du Sud participe également de ce supercomplexe. Le durcissement de Pékin depuis 2008 favorise le maintien de l’influence américaine en Asie, malgré le déclin de Washington sur la scène internationale.
Le palais d’Aiétès et son jardin chez Apollonios de Rhodes (Arg., III, v. 194-252). Un exemple de paysage-palimpseste antique ?
Authors: André Laury-Nuria 
Published: July 2012

Lorsque le lecteur découvre au chant III
des Argonautiques d’Apollonios de Rhodes
l’espace du « paysage urbain » colque, au fur et à mesure de la
progression visuelle des personnages, se dessine mentalement tout un
espace littéraire fait de réminiscences homériques. L’espace végétal
semble composé d’un bouquet d’intertextes de nature endogène tandis
que l’architecture palatiale combine structure archaïque et ornements
hellénistiques. Nulle trace d’exotisme donc, mais un espace composé de
référents grecs typiques. Du fait de ces référents littéraires, la
construction de l’espace palatial urbain emprunte sa configuration
même au type d’écriture poétique sollicité par le poète épique : la
réécriture. Comment comprendre alors que le palais d’Aiétès puisse
être à l’image du palais du souverain grec hellénistique, image idéale
d’une architecture s’inscrivant dans l’ordre divin ? Il faut voir ici
non seulement la mise en image, l’illustration concrète via
l’architecture et, partant, le « paysage urbain » qui se singularise
par sa nature hybride, de la volonté de rapprocher Orient et Occident,
mais aussi et surtout les moyens mêmes de cette mise en œuvre. Le
palais et son jardin ne seraient alors qu’une promesse, un prototype
d’un modèle idéal à étendre, grandeur nature, sur l’ensemble du
territoire colque, et de l’oïkoumène tout
entière.