bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prioritizing cancer-related genes with aberrant methylation based on a weighted protein-protein interaction network
Authors: Liu Hui , Su Jianzhong , Li Junhua , Liu Hongbo , Lv Jie , Li Boyan , Qiao Hong , Zhang Yan 
Published: October 2011

Abstract

Background
As an important epigenetic modification, DNA methylation plays a crucial role in the development of mammals and in the occurrence of complex diseases. Genes that interact directly or indirectly may have the same or similar functions in the biological processes in which they are involved and together contribute to the related disease phenotypes. The complicated relations between genes can be clearly represented using network theory. A protein-protein interaction (PPI) network offers a platform from which to systematically identify disease-related genes from the relations between genes with similar functions.

Results
We constructed a weighted human PPI network (WHPN) using DNA methylation correlations based on human protein-protein interactions. WHPN represents the relationships of DNA methylation levels in gene pairs for four cancer types. A cancer-associated subnetwork (CASN) was obtained from WHPN by selecting genes associated with seed genes which were known to be methylated in the four cancers. We found that CASN had a more densely connected network community than WHPN, indicating that the genes in CASN were much closer to seed genes. We prioritized 154 potential cancer-related genes with aberrant methylation in CASN by neighborhood-weighting decision rule. A function enrichment analysis for GO and KEGG indicated that the optimized genes were mainly involved in the biological processes of regulating cell apoptosis and programmed cell death. An analysis of expression profiling data revealed that many of the optimized genes were expressed differentially in the four cancers. By examining the PubMed co-citations, we found 43 optimized genes were related with cancers and aberrant methylation, and 10 genes were validated to be methylated aberrantly in cancers. Of 154 optimized genes, 27 were as diagnostic markers and 20 as prognostic markers previously identified in literature for cancers and other complex diseases by searching PubMed manually. We found that 31 of the optimized genes were targeted as drug response markers in DrugBank.

Conclusions
Here we have shown that network theory combined with epigenetic characteristics provides a favorable platform from which to identify cancer-related genes. We prioritized 154 potential cancer-related genes with aberrant methylation that might contribute to the further understanding of cancers.
Classification of Viable and Non-Viable Spinach (Spinacia Oleracea L.) Seeds by Single Seed near Infrared Spectroscopy and Extended Canonical Variates Analysis
Authors: Olesen Merete Halkjaer , Shetty Nisha , Gislum Rene , Boelt Birte 
Published: October 2011

Figures 3(a) and 4(a) of this paper published as J. Near Infrared Spectrosc. 19(3), 171–180 (2011) were incorrect. The correct version of these figures is printed below. We apolgise for any confusion. [Figure: see text] [Figure: see text]
Atorvastatin therapy decreases androstenedione and dehydroepiandrosterone sulphate concentrations in patients with polycystic ovary syndrome: randomized controlled study
Authors: Sathyapalan Thozhukat , Smith Karen A , Coady Anne-Marie , Kilpatrick Eric S , Atkin Stephen L 
Published: October 2011

Background Hyperandrogenaemia in polycystic ovary syndrome (PCOS) represents a composite of raised serum concentrations of testosterone, androstenedione, dehydroepiandrosterone (DHEA) and DHEA sulphate (DHEAS). In patients with PCOS, testosterone and androstenedione are primarily derived from the ovaries and DHEAS is a metabolite predominantly from the adrenals. It has been shown that atorvastatin reduces testosterone concentrations in patients with PCOS. The objective was to study the effect of atorvastatin on serum androstenedione and DHEAS concentrations in patients with PCOS. Methods A randomized, double-blind, placebo-controlled study was performed. Forty medication-naive patients with PCOs were randomized to either atorvastatin 20mg daily or placebo for three months. Subsequently, a three-month extension study for all patients was undertaken with metformin 1500 mg daily. The main outcome measures were change in androstenedione and DHEAS concentrations. Results The mean (SD) baseline androstenedione (5.7 [0.8] versus 5.6 [1.3] nmol/L; P = 0.69) and DHEAS (7.1 [1.0] versus 7.2 [1.2] μmol/L; P = 0.72) concentrations were comparable between two groups. There was a significant reduction of androstenedione (5.7 [0.8] versus 4.7 [0.7] nmol/L; P = 0.03) and DHEAS (7.1 [1.0] versus 6.0 [0.9] μmol/L; P = 0.02) with three months of atorvastatin while there were no significant changes with placebo. Three months' treatment with metformin maintained the reduction of androstenedione and DHEAS concentrations with atorvastatin compared with baseline. There were no changes in either DHEAS or androstenedione concentrations in the initial placebo group after 12 weeks of metformin. Conclusions Twelve weeks of atorvastatin significantly reduced both DHEAS and androstenedione contributing to the total reduction of androgen concentrations and indicating that the reduction of the hyperandrogenaemia could be partly due to the action of atorvastatin at both the ovary and the adrenal gland in PCOS.
Neuroleptic Malignant Syndrome Associated with the Use of Prochlorperazine in a Patient with a Recent History of Antipsychotic-Induced Neuroleptic Malignant Syndrome
Authors: Musselman Megan E , Browning Linda A , Parker Dennis , Saely Suprat 
Published: October 2011

Objective: To describe a case of neuroleptic malignant syndrome (NMS) associated with the use of prochlorperazine in a patient recently hospitalized for NMS secondary to olanzapine. Case Summary: A 28-year-old African American male with a history of schizophrenia was hospitalized 22 days prior to the current admission for an episode of olanzapine-induced NMS. The patient was discharged from our hospital to an outside psychiatric facility. At this facility, the patient developed nausea and was given 2 doses (unknown amount and route) of prochlorperazine. Over the next 24 hours, the patient exhibited signs and symptoms of NMS including fever, agitation, and muscle rigidity. He was transported to the emergency department and became increasingly agitated. Upon admission, the patient was hyperthermic (rectal temperature 39 °C) and tachycardic (heart rate 138 beats/min), with an elevated white blood cell count of 13.5 × 103/μL, creatine kinase 431 units/L, serum sodium 150 mEq/L, blood urea nitrogen 25 mg/dL, and creatinine 1.1 mg/dL A diagnosis of NMS was speculated and infectious causes were excluded. The patient was treated with aggressive fluid resuscitation and rapid cooling measures, as well as bromocriptine and lorazepam. Cooling measures were used for 48 hours, during which time the creatine kinase, white blood cell count, sodium, blood urea nitrogen, and creatinine gradually normalized. The patient was discharged to a psychiatry facility with a treatment regimen of oxcarbazepine 600 mg twice daily, lorazepam 2 mg 3 times daily, and clozapine 25 mg at bedtime, which was titrated over 2 months to 200 mg twice daity. There have been no further occurrences of NMS. Discussion: The patient had all of the major characteristics of NMS with no other likely causative factors that may have contributed to his illness. Use of the Naranjo probability scale suggested that NMS was probably related to prochlorperazine. This case highlights the potential increased risk with the use of prochlorperazine in a patient with a history of olanzapine-induced NMS. Conclusions: NMS should be considered as a rare complication of therapy with antipsychotics and agents that alter dopamine activity, especially in patients with a history of the syndrome. Careful consideration should be given regarding the risks and benefits of using non-antipsychotic dopamine antagonists in patients with a history of antipsychotic-induced NMS.
Growth and Predictors of Growth Restraint in Moderately Preterm Children Aged 0 to 4 Years
Authors: Bocca-Tjeertes Inger F. A. , Kerstjens Jorien M. , Reijneveld Sijmen A. , de Winter Andrea F. , Bos Arend F. 
Published: October 2011

OBJECTIVE:
To describe growth in moderately preterm-born children, determine the prevalence of growth restraint at the age of 4, and identify predictors of growth restraint. We hypothesized that growth in moderately preterm-born children differs from growth in term-born children and that growth restraint is more prevalent in those born prematurely.

PATIENTS AND METHODS:
This was a community-based cohort study of 1123 children born moderately prematurely (gestational age [GA]: 32–3567 weeks) between January 2002 and June 2003.

RESULTS:
On average, we found that moderately preterm-born children were shorter and weighed less at each assessment during the first 4 years of life than their term-born counterparts. Thirty-two boys (5.6%) and 18 girls (3.8%) were growth-restricted in height, and 21 boys (3.4%) and 27 girls (5.8%) were growth-restricted in weight. Their growth in head circumference was normal compared with term-born children. In addition, growth restraint was associated with being small for GA at birth (odds ratio [OR] for height: 7.7 [95% confidence interval (CI): 2.9–20.4]; OR for weight: 9.5 [95% CI: 3.9–23.1]) and maternal height below −1 SD (OR for height: 4.9 [95% CI: 2.6–10.2]; OR for weight: 2.6 [95% CI: 1.3–5.2]). Poor head-circumference growth was associated with a low level of maternal education (OR: 5.3 [95% CI: 1.4–20.8]).

CONCLUSIONS:
Growth in moderately preterm-born children significantly differs from that of term-born children. Predictors at birth are being small for GA, maternal height below −1 SD, and a low level of maternal education. The fact that growth in moderately preterm-born children may lag warrants close monitoring during routine practice. Additional research on prevention of growth restraint is needed.
Diabetes, Glycemic Control, and Risk of Tuberculosis
Authors: Leegaard Anne , Riis Anders , Kornum Jette B. , Prahl Julie B. , Thomsen Vibeke Ø , Sørensen Henrik Toft , Horsburgh C. Robert , Thomsen Reimar W. 
Published: October 2011

OBJECTIVE
To examine the association between diabetes, glycemic control, and risk of tuberculosis (TB).

RESEARCH DESIGN AND METHODS
We conducted a population-based case-control study in Northern Denmark. Cases of active TB were all individuals with a first-time principal hospital diagnosis of TB between 1980 and 2008. Each case subject was matched with up to five population control subjects with similar age, sex, place and length of residence in Denmark, and country of emigration. We computed odds ratios (ORs) for a first-time TB diagnosis among people with and without diabetes using regression to control for other comorbidities, alcoholism, immunosuppressive medications, and socioeconomic markers.

RESULTS
We identified 2,950 patients, including 156 diabetic individuals (5.3%), with active TB, and 14,274 population control subjects, of which 539 had diabetes (3.8%). The adjusted OR for active TB among subjects with diabetes was 1.18 (95% CI 0.96–1.45) compared with nondiabetic individuals. We found a similar risk increase from diabetes in the 843 (29%) TB case subjects who were immigrants; adjusted OR = 1.23 (95% CI 0.78–1.93). In a subset with laboratory data, diabetic individuals with an HbA1c &lt;7.0, 7–7.9, and ≥8.0% had ORs of 0.91 (0.51–1.63), 1.05 (0.41–2.66), and 1.19 (CI 0.61–2.30), respectively, compared with individuals without diabetes.

CONCLUSIONS
In the low TB–burden country of Denmark, the TB risk increase associated with diabetes is substantially lower than previously suggested. We found no evidence for any association between TB and dysglycemia.
Implementation of a limited set of SSR markers for screening of genetic variability in Latvian and Swedish sour cherry (Prunus cerasus L.) genetic resources collections
Authors: Lācis Gunārs , Rashal Isaak , Trajkovski Viktor 
Published: October 2011

Implementation of a limited set of SSR markers for screening of genetic variability in Latvian and Swedish sour cherry (Prunus cerasusL.) genetic resources collectionsForty-one sour cherry (Prunus cerasusL.) accessions were evaluated using three SSR markers to characterise genetic diversity in the sour cherry genetic resource collections at the Latvia State Institute of Fruit-Growing (LIFG), Dobele, Latvia and the Division of Horticultural Genetics and Plant Breeding at Balsgård, Department of Crop Sciences, Swedish University of Agricultural Sciences (SLU-Balsgård), Sweden, and to test the usability and reliability of a small set of SSR markers for preliminary characterisation of sour cherry germplasm collections. The SSR loci were highly polymorphic with 7-14 alleles per locus. Heterozygosity and Polymorphic Information Content values ranged from 0.750 to 1.000 and 0.748-0.899, respectively, while discrimination power per locus varied from 0.716 to 0.965. Five to thirty genotypes were found in the sour cherry collections for the three tested SSR loci. The combined discrimination power of all loci was effectively 0.994 and 0.999 for the LIFG and SLU-Balsgård collections, respectively. The SSRs used were able to uniquely identify all accessions in the analysed genetic resources collections. The genotype data allowed estimation of genetic diversity and genetic characterisation of accessions in the collections. Genetic similarity analysis showed higher genetic similarity among the Baltic and Scandinavian sour cherry varieties, than between Baltic and Eastern European varieties.
Present-day changes in the morphology of the shore zone in the conditions of heavy tourist use: the case of Lake Czarne (upper Parsęta catchment)
Authors: Cichoń Małgorzata 
Published: October 2011

Present-day changes in the morphology of the shore zone in the conditions of heavy tourist use: the case of Lake Czarne (upper Parsęta catchment)
So far, works on the effect of tourist use on relief have usually focused on mountain areas. Research confirms that changes in montane geoecosystems are not always a natural manifestation of landscape evolution, but often result from poorer resistance to degradation caused by heavy tourist traffic. In spite of a great number of studies concerning this problem, few address the effect of tourists on the geographical environment of lake-land areas. Hence, Lake Czarne was selected to determine the dynamics of morphogenetic changes in its shore area, especially in the scarp zone, with the help of geodetic surveys and studies of tourist capacity conducted in the years 2006-2009. On the basis of observations and the research, four stages in the evolution of the shore zone of Lake Czarne were distinguished that were correlated with specific meteorological and hydrological conditions affecting the number of recreationists on the beach.
Erosional-denudational valleys and their significance for the reconstruction of the Late Glacial environmental conditions (The Drawsko Lakeland, NW Poland)
Authors: Paluszkiewicz Renata 
Published: October 2011

Erosional-denudational valleys and their significance for the reconstruction of the Late Glacial environmental conditions (The Drawsko Lakeland, NW Poland)
The article presents the morphological-lithological development and operation of dry erosional-denudational valleys located on morainic uplands in the Drawsko Lakeland. A detailed research was carried out on the morainic upland of the Buślarka and Piaski Pomorskie area. A geodetic study made it possible to identify over ten NW-SE and N-S oriented erosional-denudational valleys, clearly marked in the relief. They are small landforms: their length does not exceed 100 m, and the depth of incision reaches 4 m. Their exact morphometric description with the help of GIS methods and a detailed study of lithofacies characteristics of their deposits provided an insight into their operation. They follow a Late Glacial pattern in which Late Vistulian erosion only rejuvenated the already existing older forms.
Hail occurrence in Poland
Authors: Suwała Katarzyna 
Published: October 2011

Hail occurrence in Poland
The main objective of this study was to present the spatial and temporal distribution of hail in Poland covering the period of 1973-2009. The analysis was based on the data for 23 meteorological stations published by The Institute of Meteorology and Water Management (1973-1980) and National Climatic Data Center (for the years 1981 to 2009). The results are presented with the maps of mean monthly and annual number of hail days, histograms of the seasonal variation of hail and trend lines in temporal variability of hail. It shows that in Poland the mean annual number of hail days varies from 1,3 near Suwałki to 10 near Hel. Most of the hail cases occurred in March, when the number of mean monthly hail days amounted almost 15. When it comes to temporal variability it is characterized by increasing tendency with the maximum at the beginning of 2000.
What is the Role of the Stagnation Region in Karman Vortex Shedding?
Authors: Pankanin Grzegorz 
Published: October 2011

What is the Role of the Stagnation Region in Karman Vortex Shedding?This paper is devoted to the problem of the appearance of a stagnation region during Karman vortex shedding. This particular phenomenon has been addressed by G. Birkhoff in his model of vortices generation. Experimental results obtained by various research methods confirm the existence of a stagnation region. The properties of this stagnation region have been described based on experimental findings involving flow visualisation and hot-wire anemometry. Special attention has been paid to the relationship between the existence of a slit in the bluff body and the size of the stagnation region. The slit takes over the role of the stagnation region as an information channel for generating vortices.
Larval instars of Appendiseta robiniae (Gillette, 1907) (Hemiptera: Aphidoidea: Drepanosiphidae)
Authors: Borowiak-Sobkowiak Beata , Durak Roma 
Published: October 2011

Larval instars of Appendiseta robiniae (Gillette, 1907) (Hemiptera: Aphidoidea: Drepanosiphidae)
Appendiseta robiniae (Gillette, 1907) is a species relatively recently recorded in the Polish fauna. In the development of A. robiniae 4 larval instars were observed prior to the adult. The morphometric parameters of each larval instar were defined. DFA analysis indicated that the best parameters distinguishing the instars of A. robiniae are antenna and body lengths. DFA analysis confirmed that larval growth is the fastest between the third and fourth instars.
Some agarics in the subalpine and alpine belts of the Altaj (Russia) and Tyan'-Shan' (Kyrgyzstan) mountains
Authors: Kalamees K. 
Published: October 2011

Some agarics in the subalpine and alpine belts of the Altaj (Russia) and Tyan'-Shan' (Kyrgyzstan) mountains
Systematic and ecological data are presented on some agarics recorded in the subalpine and alpine belts of the Altaj (Russia) and Tyan'-Shan' (Kyrgyzstan) mountains, collected in the years 1969 and 1971. The treated species are: Cortinarius subtorvus Lamoure, Inocybe giacomi Favre, Hemimycena phlomisii Kalamees (spec. nov.), Melanoleuca cognata (Fr.) Konrad & Maubl. s.l., Rickenella fibula (Bull. : Fr.) Raithelhub., Rugosomyces caucasicus (Singer) Kalamees, Lactarius brunneoviolaceus M.P. Christ. and L. dryadophilus Kühner.
The Helotiales of the Magadan and Chukotka areas of the Russian Arctic
Authors: Raitviir A. 
Published: October 2011

The Helotiales of the Magadan and Chukotka areas of the Russian Arctic
Forty-four species of Helotiales are reported from two eastern areas, Magadan and Chukotka, of the Russian Arctic. Two new genera of Dermateaceae, Arctomollisia and Larissia, and 7 new species, Arctomollisa kolymensis, Hysteronaevia vassiljevae, Larissia pyrolae, Leptotrochila chamaemori, Nimbomollisia novosieversiae, Pseudonaevia epilobii (Dermateaceae), and Gorgoniceps arctica (Helotiaceae) are described. A new combination, Arctomollisia oxyparaphysata, is proposed.
Travail féminin et fécondité hors mariage en Allemagne au cours des années 1990 : comparaison entre l'Est et l'Ouest
Authors: Konietzka Dirk , Kreyenfeld Michaela 
Published: October 2011

Résumé Avant la réunification, mariage et procréation étaient étroitement associés en Allemagne de l’Ouest (RFA) tandis qu’en Allemagne de l’Est (RDA), la proportion de naissances hors mariage était élevée. On a attribué ce phénomène aux effets des politiques familiales de la RDA qui encourageaient les mères non mariées à rester célibataires. Après la réunification, les institutions politiques et juridiques de la RDA – y compris les politiques familiales – ont été remplacées par celles de la RFA. Dès lors, beaucoup s’attendaient à ce que la proportion de naissances hors mariage baisse assez rapidement en Allemagne orientale et rejoigne celle de l’Allemagne occidentale ; mais, tout au contraire, elle a encore augmenté. Pour les auteurs de cet article, l’énorme écart observé au cours des années 1990 entre l’Est et l’Ouest du pays en matière de fécondité hors mariage peut être imputé à une différence d’attitude des femmes à l’égard du travail. Malgré des conditions défavorables sur le marché du travail et une politique sociale qui encourage les femmes à quitter leur emploi après une naissance, les Allemandes de l’Est ont toujours plus tendance à travailler à temps plein que leurs consœurs de l’Ouest et reprennent le travail plus vite après la naissance. Cette recherche, qui exploite les données du micro-recensement de 1997, révèle la forte influence du niveau d’instruction et du travail des femmes sur le mariage en Allemagne de l’Ouest, tandis qu’en Allemagne de l’Est, la probabilité d’être mariée n’est presque pas corrélée avec l’activité professionnelle. Les auteurs concluent que la forte propension générale à exercer un emploi et l’abondance des services publics de garderie pour les enfants sont les principaux éléments qui réduisent l’effet des incitations économiques au mariage chez les jeunes mères est-allemandes.
Célibat définitif et mariage tardif aux Pays-Bas, 1890-1960
Authors: Engelen Theo , Kok Jan 
Published: October 2011

Résumé Cet article traite des deux mécanismes bien connus de limitation de l’accès au mariage en Europe. La question est de savoir si le célibat définitif est une conséquence non intentionnelle du report du mariage, ou s’il peut être vu comme un phénomène plus ou moins indépendant. Nous utilisons un échantillon représentatif des générations nées aux Pays-Bas de 1890 à 1909 pour comparer les trajectoires biographiques des personnes qui ne se sont jamais mariées à celles des gens qui se sont mariés à un âge avancé. Cette analyse met en évidence, selon les régions et les catégories sociales, l’existence de divers schémas de nuptialité. Le célibat définitif n’était pas simplement l’effet du retard de l’âge au mariage : nous avons rencontré toutes les combinaisons possibles en termes d’âge au mariage et de proportions de célibataires. L’analyse statistique montre que chacune de ces combinaisons avait sa logique propre pour la sous-population concernée.