bluuebunny/crossref_metadata_2025_split huggingface dataset:
Lactobacillus Reuteri Vesicles Regulate Mitochondrial Function of Macrophages to Promote Mucosal and Cutaneous Wound Healing
Authors: Chen Yuan , Huang Xiaoyao , Liu Anqi , Fan Siyuan , Liu Shiyu , Li Zihan , Yang Xiaoxue , Guo Hao , Wu Meiling , Liu Meng , Liu Peisheng , Fu Fei , Liu Siying , Xuan Kun 
Published: April 2024

AbstractThe interplay between bacteria and their host influences the homeostasis of the human immune microenvironment, and this reciprocal interaction also affects the process of tissue damage repair. A variety of immunomodulatory commensal bacteria reside in the body, capable of delivering membrane vesicles (MVs) to host cells to regulate the local immune microenvironment. This research revealed, for the initial time, the significant enhancement of mucosal and cutaneous wound healing by MVs secreted by the human commensal Lactobacillus reuteri (RMVs) through modulation of the inflammatory environment in wound tissue. Local administration of RMVs reduces the proportion of pro‐inflammatory macrophages in inflamed tissues and mitigates the level of local inflammation, thereby facilitating the healing of oral mucosa and cutaneous wounds. The elevated oxidative stress levels in activated pro‐inflammatory macrophages can be modulated by RMVs, resulting in phenotypic transformation of macrophages. Furthermore, 3‐hydroxypropionaldehyde present in RMVs can decrease the mitochondrial permeability of macrophages and stabilize the mitochondrial membrane potential, thereby promoting the conversion of macrophages to an anti‐inflammatory phenotype. This study pioneers the significance of commensal bacterial MVs in tissue injury repair and presents a novel concept for the repair of tissue damage.
Structural Design and Energy and Environmental Applications of Hydrogen‐Bonded Organic Frameworks: A Systematic Review
Authors: Liu Xiaoming , Liu Guangli , Fu Tao , Ding Keren , Guo Jinrui , Wang Zhenran , Xia Wei , Shangguan Huayuan 
Published: April 2024

AbstractHydrogen‐bonded organic frameworks (HOFs) are emerging porous materials that show high structural flexibility, mild synthetic conditions, good solution processability, easy healing and regeneration, and good recyclability. Although these properties give them many potential multifunctional applications, their frameworks are unstable due to the presence of only weak and reversible hydrogen bonds. In this work, the development history and synthesis methods of HOFs are reviewed, and categorize their structural design concepts and strategies to improve their stability. More importantly, due to the significant potential of the latest HOF‐related research for addressing energy and environmental issues, this work discusses the latest advances in the methods of energy storage and conversion, energy substance generation and isolation, environmental detection and isolation, degradation and transformation, and biological applications. Furthermore, a discussion of the coupling orientation of HOF in the cross‐cutting fields of energy and environment is presented for the first time. Finally, current challenges, opportunities, and strategies for the development of HOFs to advance their energy and environmental applications are discussed.
A Dynamic Ultrasound Phantom with Tissue‐Mimicking Mechanical and Acoustic Properties
Authors: Fernandez Sara V. , Kim Jin‐Hoon , Sadat David , Marcus Colin , Suh Emma , Mclntosh Rachel , Shah Aastha , Dagdeviren Canan 
Published: April 2024

AbstractTissue‐mimicking phantoms are valuable tools that aid in improving the equipment and training available to medical professionals. However, current phantoms possess limited utility due to their inability to precisely simulate multiple physical properties simultaneously, which is crucial for achieving a system understanding of dynamic human tissues. In this work, novel materials design and fabrication processes to produce various tissue‐mimicking materials (TMMs) for skin, adipose, muscle, and soft tissue at a human scale are developed. Target properties (Young's modulus, density, speed of sound, and acoustic attenuation) are first defined for each TMM based on literature. Each TMM recipe is developed, associated mechanical and acoustic properties are characterized, and the TMMs are confirmed to have comparable mechanical and acoustic properties with the corresponding human tissues. Furthermore, a novel sacrificial core to fabricate a hollow, ellipsoid‐shaped bladder phantom complete with inlet and outlet tubes, which allow liquids to flow through and expand this phantom, is adopted. This dynamic bladder phantom with realistic mechanical and acoustic properties to human tissues in combination with the developed skin, soft tissue, and subcutaneous adipose tissue TMMs, culminates in a human scale torso tank and electro‐mechanical system that can be systematically utilized for characterizing various medical imaging devices.
Multifunctional Fluoropolymer‐Engineered Magnetic Nanoparticles to Facilitate Blood‐Brain Barrier Penetration and Effective Gene Silencing in Medulloblastoma
Authors: Forgham Helen , Zhu Jiayuan , Huang Xumin , Zhang Cheng , Biggs Heather , Liu Liwei , Wang Yi Cheng , Fletcher Nicholas , Humphries James , Cowin Gary , Mardon Karine , Kavallaris Maria , Thurecht Kristofer , Davis Thomas P. , Qiao Ruirui 
Published: April 2024

AbstractPatients with brain cancers including medulloblastoma lack treatments that are effective long‐term and without side effects. In this study, a multifunctional fluoropolymer‐engineered iron oxide nanoparticle gene‐therapeutic platform is presented to overcome these challenges. The fluoropolymers are designed and synthesized to incorporate various properties including robust anchoring moieties for efficient surface coating, cationic components to facilitate short interference RNA (siRNA) binding, and a fluorinated tail to ensure stability in serum. The blood‐brain barrier (BBB) tailored system demonstrates enhanced BBB penetration, facilitates delivery of functionally active siRNA to medulloblastoma cells, and delivers a significant, almost complete block in protein expression within an in vitro extracellular acidic environment (pH 6.7) – as favored by most cancer cells. In vivo, it effectively crosses an intact BBB, provides contrast for magnetic resonance imaging (MRI), and delivers siRNA capable of slowing tumor growth without causing signs of toxicity – meaning it possesses a safe theranostic function. The pioneering methodology applied shows significant promise in the advancement of brain and tumor microenvironment‐focused MRI‐siRNA theranostics for the better treatment and diagnosis of medulloblastoma.
Alcohol‐Processable All‐Polymer n‐Type Thermoelectrics
Authors: Fan Xinyi , Liu Jian , Duan Xiaozheng , Li Hongxiang , Deng Sihui , Kuang Yazhuo , Li Jingyu , Lin Chengjiang , Meng Bin , Hu Junli , Wang Shumeng , Liu Jun , Wang Lixiang 
Published: April 2024

AbstractThe general strategy for n‐type organic thermoelectric is to blend n‐type conjugated polymer hosts with small molecule dopants. In this work, all‐polymer n‐type thermoelectric is reported by dissolving a novel n‐type conjugated polymer and a polymer dopant, poly(ethyleneimine) (PEI), in alcohol solution, followed by spin‐coating to give polymer host/polymer dopant blend film. To this end, an alcohol‐soluble n‐type conjugated polymer is developed by attaching polar and branched oligo (ethylene glycol) (OEG) side chains to a cyano‐substituted poly(thiophene‐alt‐co‐thiazole) main chain. The main chain results in the n‐type property and the OEG side chain leads to the solubility in hexafluorineisopropanol (HFIP). In the polymer host/polymer dopant blend film, the Coulombic interaction between the dopant counterions and the negatively charged polymer chains is reduced and the ordered stacking of the polymer host is preserved. As a result, the polymer host/polymer dopant blend exhibits the power factor of 36.9 µW m−1 K−1, which is one time higher than that of the control polymer host/small molecule dopant blend. Moreover, the polymer host/polymer dopant blend shows much better thermal stability than the control polymer host/small molecule dopant blend. This research demonstrates the high performance and excellent stability of all‐polymer n‐type thermoelectric.
Regulating the Third Metal to Design and Engineer Multilayered NiFeM (M: Co, Mn, and Cu) Nanofoam Anode Catalysts for Anion‐Exchange Membrane Water Electrolyzers
Authors: Yang Xiaoxuan , Liang Jiashun , Shi Qiurong , Zachman Michael J. , Kabir Sadia , Liang Junwu , Zhu Jing , Slenker Benjamin , Pupucevski Max , Macauley Natalia , Kropf A. Jeremy , Zeng Hao , Strasser Derek , Myers Deborah J. , Xu Hui , Zeng Zhenhua , Yan Yushan , Wu Gang 
Published: April 2024

AbstractAlkaline anion‐exchange membrane water electrolyzers (AEMWEs) for green hydrogen production have received intensive attention due to their feasibility of using earth‐abundant platinum group metal (PGM)‐free catalysts. Herein, the third metal is incorporated into NiFe‐based catalysts to regulate their electronic structures and morphologies, aiming to achieve sufficient oxygen evolution reaction (OER) activity and performance in AEMWEs. The ternary NiFeM (M: Cu, Co, or Mn) catalysts are featured with multiple layered structures and nanofoam network morphologies, consisting of highly OER‐active amorphous Ni‐rich oxide shells and electrically conductive metallic alloy cores. The physical and electronic perturbations to the NiFe induced by a third element lead to a fine‐tuning of the redox ability of the metal sites at the reaction centers, which breaks the scaling relationship between OH* and O* intermediates at the reaction centers. Thus, the unique structural configuration and electronic regulation simultaneously benefit catalytic activity and performance improvements. These NiFeM nanofoam catalysts demonstrated promising anode performance in actual AEMWEs, comparable to the IrO2 reference, especially at high current densities. Notably, using various electrolytes (e.g., KOH solution or pure water) for AEMWEs exhibited a different performance trend among studied NiFeM catalysts, likely due to dynamic changes of catalysts under various OER environments.
Development of Durable Zn–MnO2 Battery via a Functionalized Hydrogel Film
Authors: Zheng Xinhua , Xu Kui , Ma Yirui , Sun Jifei , Han Bibo , Luo Ruihao , Wang Mingming , Chen Na , Song Li , Zhao Qingbiao , Chen Wei 
Published: April 2024

AbstractAqueous zinc (Zn) battery with remarkable advantages of high safety, low cost, and high reversibility is highly applauded in next‐generation low‐speed electric vehicles and large‐scale energy storage applications. However, Zn anode suffers from a series of unfavorable reactions, hindering its progress toward industrialization. Herein, a functionalized hydrogel film is designed using polydopamine and polyacrylamide crosslinking (PDAM) as the Zn protective layer to stabilize the Zn anode. Benefiting from the strong interaction of Zn2+ with PDAM, the primary solvation shell of Zn2+ is regulated by PDAM into the form of PDAM–Zn2+‐5H2O. This remodeling prevents Zn dendrite growth and inhibits water‐induced side reactions. As a result, the Zn–MnO2 battery using PDAM‐coated Zn anode exhibits excellent cycling stability, demonstrating over 1150 cycles at an areal capacity of 5 mAh cm−2 with an average Coulombic efficiency (CE) of 96.5%. For a scaled‐up PDAM@Zn–MnO2 pouch cell with a capacity of 80 mAh, stable cycling of over 200 cycles with an average CE of 91.9% is achieved. The superior Zn–MnO2 battery enabled by the functionalized hydrogel protective film enlightens an arena toward next‐generation energy storage applications.
Layered Double Hydroxides with Carbonate Intercalation as Ultra‐Stable Anodes for Seawater Splitting at Ampere‐Level Current Density
Authors: Deng Peng‐Jun , Liu Yang , Liu Huili , Li Xiaona , Lu Jiajia , Jing Shengyu , Tsiakaras Panagiotis 
Published: April 2024

AbstractOwing to the presence of a substantial concentration of chlorine in seawater, the anode still faces severe chlorine corrosion, especially the water splitting operated at high current densities. Herein, the cost‐effective and scalable NiFe layered double hydroxides with carbonate intercalation (named as NiFe LDH_CO32−) are synthesized utilizing the etching‐hydrolysis and ion exchange strategies under ambient conditions. Experimental findings demonstrate that NiFe LDH_CO32− shows excellent stability at 500 and 1000 mA cm−2 for 1000 h under alkaline simulated seawater. Additionally, a two‐electrode system offers great stability at current densities ranging from 100 to 1000 mA cm−2 over a duration of 400 h in alkaline seawater. This remarkably catalytic stability can be ascribed to the etching‐hydrolysis and carbonate intercalation strategies. The etching‐hydrolysis strategy leads to an integrated electrode for the catalyst‐carrier, enhancing the adhesion between them, and retarding hence the divorce of catalysts from the carrier. Theoretical calculations suggest that the carbonate intercalation weakens the adsorbability of chlorine on catalysts and hinders the coupling of metal atoms with chlorine, thereby impeding the anode corrosion caused by chlorine and improving catalytic stability. More importantly, this strategy has been extended to the preparation of other layered double hydroxides with carbonate intercalation.
Superfluorescence in Metal Halide Perovskites
Authors: Tang Yue , Jing Yao , Sum Tze Chien , Bruno Annalisa , Mhaisalkar Subodh G. 
Published: April 2024

AbstractSuperfluorescence (SF) is a unique quantum optical phenomenon where an ensemble of atoms or molecules exhibit coherent emission of an intense burst of light of high directionality, with temporal coherence. SF exhibits ultrafast optical characteristics and is considerably explored in diverse inorganic and hybrid semiconductor materials at cryogenic temperatures, including inorganic and hybrid metal halide perovskites. Notably, SF is reported in different perovskites’ nanocrystal superlattices, alongside two examples in thin films, impressively achieving SF at room temperature. The density of quantum emitters, excited state characteristics, interaction strengths, and temperature all affect the SF threshold. Although significant progress is reported in the observance of SF phenomena, a full interpretation of the relationship between the factors that determine the SF threshold and the intrinsic material properties remains unclear. This review addresses the current state‐of‐the‐art observations of SF in perovskite systems, such as nanocrystal superlattices and thin films, elucidating the optical properties, ultrafast dynamics, and the proposed mechanisms for room‐temperature SF. The review concludes with a discussion on the existing challenges, unresolved questions, and future perspectives for advancing perovskite SF research
Enabling and Boosting Preferential Epitaxial Zinc Growth via Multi‐Interface Regulation for Stable and Dendrite‐Free Zinc Metal Batteries
Authors: Wang Yangyang , Ren Tiantian , Wang Zeping , Liu Chengxin , Zhang Yuhang , Xu Ao , Chen Chunxia , Bai Jinbo , Wang Hui , Liu Xiaojie 
Published: April 2024

AbstractThe practical application of aqueous Zn‐metal anodes (AZMAs) is mainly impeded by the short cycling life and unsatisfactory reversibility springing from the notorious Zn dendrite growth and detrimental water‐induced parasitic reactions at anode‐electrolyte interface. To tackle these challenges, a multifunctional interface of Sn‐modified Ti3C2Cl2 MXene (denoted as Sn‐MXene) with high zincophilic and hydrophobic properties is rationally designed via a 1‐step strategy with a novel molten salt etching to achieve dendrite‐free Zn deposition. Experimental results and theoretical calculations reveal that the Sn nanoparticles can induce a strongly zincophilic surface with high Zn2+ adsorption, and the Ti3C2Cl2 MXene significantly decreases the surface energy of the Zn (002) plane, guiding the zinc‐preferred orientation along the (002) plane in the electroplating growth process. Moreover, the hydrophobic properties of ‐Cl terminations of the protective interface for the Zn anode can regulate Zn‐ion solvation structure to mitigate H2O‐decomposition‐induced side reactions, and guarantee a steady stream of Zn2+ flux. Encouragingly, benefiting from the Sn‐MXene layer, a side reaction‐free and dendrite‐free Zn anode with an excellent lifespan is achieved, which is further applied as an anode for full battery (Sn‐MXene‐Zn//α‐MnO2) with a long‐term span over 800 cycles under 1 A g–1 with a capacity retention of 96%.
Modifying Roles of CuSbSe2 in Realizing High Thermoelectric Performance of GeTe
Authors: Jin Yang , Qiu Yuting , Bai Shulin , Xie Hongyao , Liu Shibo , Hong Tao , Gao Xiang , Wen Yi , Zhao Li‐Dong 
Published: April 2024

AbstractThermoelectric materials are widely researched for their energy conversion capabilities in the fields of power generation and refrigeration. And a superior thermoelectric conversion efficiency requires an excellent power factor and low thermal conductivity. Herein, a remarkable thermoelectric figure of merit（ZT） ∼ 2.6 at 673 K is realized in GeTe with 20% addition of CuSbSe2. Multiple synergistic effects of CuSbSe2 alloying collectively contribute to the excellent thermoelectric performance in GeTe. CuSbSe2 alloying effectively tunes ultrahigh carrier density of GeTe to the optimum. The introduction of Cu, Sb, and Se atoms create numerous point defects that scatter high‐frequency phonons. Additionally, surplus CuSbSe2 facilitates the formation of copper‐selenium phases, which embed at grain boundaries and generate interfaces after sintering. Combining the planar defects evolved from Ge vacancies, multi‐dimension defects effectively scatter multiple frequency phonons. An extraordinarily low lattice thermal conductivity of 0.3 Wm−1 K−1 at 673 K is obtained, approaching the theoretical estimation predicted by Cahill model. Eventually, the peak conversion efficiency of 7.4% is obtained in segmented device with ΔT of 419 K. The commingled effects of CuSbSe2 in GeTe further open up an elitist route to designing high‐performance materials.
Unlocking the Myths of Molecular Bonding State in Modulating Oxidation and Anderson Localization for Inorganic Sn/Pb‐based Perovskite Solar Cells
Authors: Li Qin , Ma Junjie , Xu Xuanchen , Gao Peng , Cai Meng , Han Mengqi , Yang Jing , Zhang Yiqiang , Song Yanlin 
Published: April 2024

AbstractThe improvement of photovoltaic and stability performance of tin (Sn)‐based halide perovskite solar cells is impeded by notorious oxidation issues and Anderson localization. Despite previous implements in antioxidation through the incorporation of Lewis base additives, there still exist ongoing uncertainties surrounding its complex interaction mechanisms. A perplexing phenomenon regarding accelerated oxidation in acrylic acid is discovered that deviates from conventional Lewis base–acid reaction. The underlying insights into the deprotonation of acrylic acid followed by the formation of a “tripod” ionic bonding form are provided, which results in amplifying the delocalization effect of electrons of Sn2+. Furthermore, with the assistance of acrylamide and acrolein, synergistic enhancement in terms of the antioxidation and suppression of Anderson localization can be achieved — a concept referred to as “Dual Synergistic Engineering”. This suppresses the oxidation of Sn2+ and reduces Sn4+ content by ≈76%. Meanwhile, the diffusion length is prolonged significantly from 195.9 to 458.9 nm. The optimized all‐inorganic Sn/Pb‐based perovskite solar cells exhibit a power conversion efficiency of above 14% with enhanced stability. These findings provide an alternative viewpoint for comprehending the impact of chemical interaction on oxidation and crystal growth in Sn/Pb‐based perovskites.
Phenotypic consequences of GBA1 pathological variant R463C (p.R502C)
Authors: Ryan Emory , Nishimura Samantha , Lopez Grisel , Tayebi Nahid , Sidransky Ellen 
Published: April 2024

AbstractGaucher disease (GD) is an autosomal recessively inherited lysosomal storage disorder caused by biallelic pathological variants in the GBA1 gene. Patients present along a broad clinical spectrum, and phenotypes are often difficult to predict based on genotype alone. The variant R463C (p.Arg502Cys) exemplifies this challenge. To better characterize its different clinical presentations, we examined the records of 25 current and historical patients evaluated at the National Institutes of Health. Nine patients were classified as GD1, 14 were classified as GD3, and two had an ambiguous diagnosis between GD1 and GD3. In addition, we reviewed the published literature in PubMed and Web of Science through December 2023, identifying 62 cases with an R463C variant from 18 countries. Within the NIH cohort, the most common second variants were N370S (p.N409S) and L444P (p.L483P). R463C/L444P was encountered in patients with GD1 and GD3 in both the NIH cohort and worldwide. In the literature, R463C/R463C was also reported in both GD1 and GD3, although sparse phenotypic information was shared. Often the phenotype reflected what might be predicted for the second mutant allele. This diversity of phenotypes emphasizes the need for longitudinal follow‐up to assess symptom development and neurological involvement.
Differences in vertebral bone density between African apes
Authors: Korpinen Niina 
Published: April 2024

AbstractObjectivesLow‐energy vertebral fractures are a common health concern, especially in elderly people. Interestingly, African apes do not seem to experience as many vertebral fractures and the low‐energy ones are even rarer. One potential explanation for this difference is the lower bone density in humans. Yet, only limited research has been done on the vertebral bone density of the great apes and these have mainly included only single vertebrae. Hence the study aim is to expand our understanding of the vertebral microstructure of African apes in multiple spinal segments.MaterialsBone density in the vertebral body of C7, T12, and L3 was measured from 32 Pan troglodytes and 26 Gorilla gorilla using peripheral quantitative computed tomography (pQCT).ResultsThere was a clear difference between the three individual vertebrae and consequently the spinal segments in terms of trabecular density and cortical density and thickness. The variation of these bone parameters between the vertebrae differed between the apes but was also different from those reported for humans. The chimpanzees were observed to have overall higher trabecular density, but gorillas had higher cortical density and thickness. Cortical thickness had a relatively strong association with the vertebral size.DiscussionDespite the similarity in locomotion and posture, the results show slight differences in the bone parameters and their variation between spinal segments in African apes. This variation also differs from humans and appears to indicate a complex influence of locomotion, posture, and body size on the different spinal segments.