bluuebunny/crossref_metadata_2025_split huggingface dataset:
A unique human cord blood CD8+CD45RA+CD27+CD161+ T‐cell subset identified by flow cytometric data analysis using Seurat
Authors: Reyes Julen Gabirel Araneta , Ni Duan , Santner‐Nanan Brigitte , Pinget Gabriela Veronica , Kraftova Lucie , Ashhurst Thomas Myles , Marsh‐Wakefield Felix , Wishart Claire Leana , Tan Jian , Hsu Peter , King Nicholas Jonathan Cole , Macia Laurence , Nanan Ralph 
Published: May 2024

AbstractAdvances in single‐cell level analytical techniques, especially cytometric approaches, have led to profound innovation in biomedical research, particularly in the field of clinical immunology. This has resulted in an expansion of high‐dimensional data, posing great challenges for comprehensive and unbiased analysis. Conventional manual analysis is thus becoming untenable to handle these challenges. Furthermore, most newly developed computational methods lack flexibility and interoperability, hampering their accessibility and usability. Here, we adapted Seurat, an R package originally developed for single‐cell RNA sequencing (scRNA‐seq) analysis, for high‐dimensional flow cytometric data analysis. Based on a 20‐marker antibody panel and analyses of T‐cell profiles in both adult blood and cord blood (CB), we showcased the robust capacity of Seurat in flow cytometric data analysis, which was further validated by Spectre, another high‐dimensional cytometric data analysis package, and conventional manual analysis. Importantly, we identified a unique CD8+ T‐cell population defined as CD8+CD45RA+CD27+CD161+ T cell that was predominantly present in CB. We characterised its IFN‐γ‐producing and potential cytotoxic properties using flow cytometry experiments and scRNA‐seq analysis from a published dataset. Collectively, we identified a unique human CB CD8+CD45RA+CD27+CD161+ T‐cell subset and demonstrated that Seurat, a widely used package for scRNA‐seq analysis, possesses great potential to be repurposed for cytometric data analysis. This facilitates an unbiased and thorough interpretation of complicated high‐dimensional data using a single analytical pipeline and opens a novel avenue for data‐driven investigation in clinical immunology.
Academic procrastination, loneliness, and academic anxiety as predictors of suicidality among university students
Authors: Hamdan‐Mansour Ayman M. , Hamdan‐Mansour Renad A. , Allaham Dana M. , Alrashidi Mohammed , Alhaiti Ali , Mansour Laith A. Hamdan 
Published: May 2024

AbstractSuicide is a major public health concern, and university students are at higher risk of suicide than any other age group. The purpose of this study was to examine the prediction power of loneliness, academic anxiety, and academic procrastination on suicidality among university students. A cross‐sectional, correlational design was used to recruit 403 university students using the electronic survey format in Jordan. Data were collected regarding loneliness, academic anxiety, academic procrastination, and suicidality. A two‐step multiple hierarchical regression analysis was performed. Only 17.1% (n = 69) of students were at risk of suicide, low to moderate level of loneliness, moderate level and moderate to high level of academic procrastination of academic anxiety. The model that included the sociodemographic and the psychological factors was significant (F18,390 = 12.3, p < 0.001) where the total variance in suicidality was 37.3% (R2 = 0.373). Being a working student, being on psychotropic medication, romantic and family relationships domains of loneliness, and academic anxiety were found to be predictors of suicidality (p < 0.05). Suicide is a significant problem among university students. Mental health professionals and policymakers need to enhance the use and access to mental health services and seek psychological counselling to combat the increasingly observed phenomenon of suicide among young people.
Balancing flexibility and stability: The role of outsourced service stations in managing food‐delivery platform work in China
Authors: Yang Binyi 
Published: May 2024

AbstractCurrent mainstream research on on‐demand labor platforms primarily focuses on the discussion of algorithmic technologies while overlooking the issue of how platforms achieve stable operations in a de‐employment context. Addressing this research gap, this study investigates the approaches employed by Chinese food‐delivery platforms to ensure stable labor supply. Utilizing qualitative data, the research reveals that Chinese food‐delivery platforms have established stability in labor supply by implementing the outsourced model, partnering with third‐party staffing agencies to establish service stations, and managing couriers offline. This approach helps to balance platform and courier needs, addressing the tension between work flexibility and income stability. This research provides a case study illuminating the interplay between technology and the labor market in labor relations. Additionally, it highlights the structural forces that workers form within the internal labor market, deepening our understanding of platform management and the complexities of labor relations.
Detection of Novel Influenza Viruses Through Community and Healthcare Testing: Implications for Surveillance Efforts in the United States
Authors: Morris Sinead E. , Gilmer Matthew , Threlkel Ryan , Brammer Lynnette , Budd Alicia P. , Iuliano A. Danielle , Reed Carrie , Biggerstaff Matthew 
Published: May 2024

ABSTRACTBackgroundNovel influenza viruses pose a potential pandemic risk, and rapid detection of infections in humans is critical to characterizing the virus and facilitating the implementation of public health response measures.MethodsWe use a probabilistic framework to estimate the likelihood that novel influenza virus cases would be detected through testing in different community and healthcare settings (urgent care, emergency department, hospital, and intensive care unit [ICU]) while at low frequencies in the United States. Parameters were informed by data on seasonal influenza virus activity and existing testing practices.ResultsIn a baseline scenario reflecting the presence of 100 novel virus infections with similar severity to seasonal influenza viruses, the median probability of detecting at least one infection per month was highest in urgent care settings (72%) and when community testing was conducted at random among the general population (77%). However, urgent care testing was over 15 times more efficient (estimated as the number of cases detected per 100,000 tests) due to the larger number of tests required for community testing. In scenarios that assumed increased clinical severity of novel virus infection, median detection probabilities increased across all healthcare settings, particularly in hospitals and ICUs (up to 100%) where testing also became more efficient.ConclusionsOur results suggest that novel influenza virus circulation is likely to be detected through existing healthcare surveillance, with the most efficient testing setting impacted by the disease severity profile. These analyses can help inform future testing strategies to maximize the likelihood of novel influenza detection.
Impression formation of majority and minority applicants during resume screening—Does processing more information reduce prejudice?
Authors: Sachs Tobias , Homan Astrid C. , Lancee Bram 
Published: May 2024

AbstractWhile previous research has consistently found evidence for ethnic discrimination after resume screening, the majority of those studies focused on outcomes of evaluating job applications. Therefore, we know little about what happens during resume screening. In the present study (N = 402), we tested whether impressions of majority and minority applicants are formed differently while processing separate snippets from job applications. While majority impressions were significantly more positive than minority impressions after the third snippet was processed, impressions did not differ anymore after four or more snippets. In specific, minority impressions improved significantly more in response to the fourth snippet, which provided information on a volunteering role. Furthermore, we found that negative information similarly harmed majority and minority impressions. Our findings suggest that minority applicants might suffer from prejudice if only little information from resumes is being processed. Thus, organizations might be able to prevent discriminatory outcomes by avoiding superficial resume screening.
Hidden in plain sight: delayed ADHD diagnosis among girls and women – a commentary on Skoglund et al. (2023)
Authors: Agnew‐Blais Jessica C. 
Published: May 2024

Skoglund et al. (Journal of Child Psychology and Psychiatry, 2023) finds women with ADHD experience a nearly 4‐year delay in receiving an ADHD diagnosis compared to men, despite also having high rates of prior contact with the mental health care system. In this commentary, I discuss the findings of Skoglund et al. and how they shed light on possible explanations for this diagnostic delay among women, and the need to consider women‐specific issues, like times of hormonal change, in ADHD diagnosis and treatment.
Moving forward. Use of the START NOW skills training program for female youth with ODD and CD – a commentary on Stadler et al. (2024)
Authors: Tripp Gail 
Published: May 2024

Female youth with oppositional defiant disorder (ODD) and conduct disorder (CD) are an under studied and underserved population at high risk for poor adjustment in later life. Stadler et al. (2024) attempt to redress this situation for adolescent females with CD or ODD with an adapted version of the skills training program START NOW. They describe the results of an ambitious randomized control trial, comparing START NOW with standard care in youth welfare settings in Germany, Switzerland, and The Netherlands. The findings appear promising, but the paper is especially valuable for the spotlight it shines on the needs of this underserved population and those caring for them, together with the importance of undertaking such trials despite their challenges. This commentary seeks to encourage readers to engage with the START NOW trial.
Five aspects of research waste in biomedicine: A scoping review
Authors: Rosengaard Louise Olsbro , Andersen Mikkel Zola , Rosenberg Jacob , Fonnes Siv 
Published: May 2024

AbstractBackgroundThe number of published journal articles has grown exponentially during the last 30 years, which may have led to some wasteful research. However, the terminology associated with research waste remains unclear. To address this, we aimed to identify, define, and categorize the aspects of research waste in published biomedical reports.MethodsIn this scoping review, we systematically searched for biomedical literature reports from 1993 to 2023 in two databases, focusing on those addressing and defining research waste. Through data charting, we analyzed and categorized the aspects of research waste.ResultsBased on 4285 initial records in the searches, a total of 832 reports were included in the analysis. The included reports were primarily narrative reviews (26%) and original reports (21%). We categorized research waste into five aspects: methodological, invisible, negligible, underreported, and structural (MINUS) research waste. More than half of the reports (56%) covered methodological research waste concerning flaws in study design, study conduct, or analysis. Invisible research waste covered nonpublication, discontinuation, and lack of data‐sharing. Negligible research waste primarily concerned unnecessary repetition, for example, stemming from the absence of preceding a trial with a systematic review of the literature. Underreported research waste mainly included poor reporting, resulting in a lack of transparency. Structural research waste comprised inadequate management, collaboration, prioritization, implementation, and dissemination.ConclusionMINUS encapsulates the five main aspects of research waste. Recognizing these aspects of research waste is important for addressing and preventing further research waste and thereby ensuring efficient resource allocation and scientific integrity.
Review of current perspectives and future outlook on bacterial disease prevention through vaccination in Asian seabass (Lates calcarifer)
Authors: Lan Nguyen Giang Thu , Dong Ha Thanh , Shinn Andrew P. , Vinh Nguyen Tien , Senapin Saengchan , Salin Krishna R. , Rodkhum Channarong 
Published: May 2024

AbstractAsian seabass, Lates calcarifer, is an important aquatic species in mariculture. Intensive farming of this species has faced episodes of bacterial diseases, including those due to vibriosis, scale drop, and muscle necrosis disease, big belly disease, photobacteriosis, columnaris, streptococcosis, aeromoniasis, and tenacibaculosis. Vaccination is one of the most efficient, non‐antibiotic, and eco‐friendly strategies for protecting fish against bacterial diseases, contributing to aquaculture expansion and ensuring food security. As of now, although numerous vaccines have undergone laboratory research, only one commercially available inactivated vaccine, suitable for both immersion and injection administration, is accessible for preventing Streptococcus iniae. Several key challenges in developing vaccines for Asian seabass must be addressed, such as the current limited understanding of immunological responses to vaccines, the costs associated with vaccine production, forms, and routes of vaccine application, and how to increase the adoption of vaccines by farmers. The future of vaccine development for the Asian seabass industry, therefore, is discussed with these key critical issues in mind. The focus is on improving our understanding of Asian seabass immunity, including maternal immunity, immunocompetence, and immune responses post‐vaccination, as well as developing tools to assess vaccine effectiveness. The need for an alignment of fish vaccines with state‐of‐the‐art vaccine technologies employed in human and terrestrial animal healthcare is also discussed. This review also discusses the necessity of providing locally‐produced autogenous vaccines, especially for immersion and oral vaccines, to benefit small‐scale fish farmers, and the potential benefits that might be extended through changes to current husbandry practices such as the vaccination of broodstock and earlier life stages of their off‐spring.
Applying human‐centered design to adapt the Jumpstart Guide for goals‐of‐care discussions in persons living with dementia
Authors: Im Jennifer , Kross Erin K. , Engelberg Ruth A. , Dotolo Danae G. , Ungar Anna , Nielsen Elizabeth , Torrence Janaki , Abedini Nauzley C. 
Published: May 2024

AbstractBackgroundGoals‐of‐care discussions (GOCD) are uncommon in persons living with dementia (PLWD) despite the likelihood of eventual loss of decisional capacity in the population. The Jumpstart Guide, an existing serious illness communication priming tool, can improve GOCD in certain populations, but has not previously been adapted for use among PLWD and their caregivers.MethodsUsing human‐centered design (HCD), we adapted the Jumpstart Guide for use with PLWD and their caregivers. We conducted qualitative interviews with clinicians and caregivers of PLWD. Six team members conducted qualitative rapid analysis of interviews leading to the development of summary templates and integrative matrices. Four iterations of the Jumpstart Guide led to the final version.ResultsThirteen clinicians and 11 caregivers were interviewed. Interviews provided key insights into the unique barriers PLWD and their caregivers face during GOCD, including discomfort with accepting a dementia diagnosis and concern with using “serious illness” to describe dementia, as is commonly done in palliative care. Clinicians described differences in GOCD with PLWD compared to other serious illnesses, and the challenge of getting patients and families to think about future health states. Interviews led to Jumpstart Guide adaptations in the following domains: (1) format and structure, (2) content, and (3) specific language. Suggested changes included prioritizing naming a decision‐maker, changing conversation prompts to improve accessibility and understandability, ensuring the Jumpstart Guide could be used with patients as well as their caregivers, and altering language to avoid references to “serious illness” and “abilities.”ConclusionUsing HCD yielded valuable insights from clinicians and caregivers about the unique barriers to conducting GOCD among PLWD and their caregivers. These insights were used to adapt the Jumpstart Guide for use with PLWD and their caregivers, which is currently being tested in a pragmatic randomized controlled trial in outpatient clinics.
Dietary habits and self‐reported health outcomes in a cross‐sectional survey of health‐conscious adults eating a plant‐based diet
Authors: Sadler Isabelle , Bauer Alexander , Kassam Shireen 
Published: May 2024

AbstractBackgroundGiven the growing popularity of plant‐based diets, this study investigated the dietary habits and self‐reported health outcomes of health‐conscious adults consuming plant‐based diets.MethodsA cross‐sectional online survey (n = 315) was distributed to members of Plant‐Based Health Professionals UK, a community interest company. Dietary intake was assessed through a food frequency questionnaire. Data were summarised descriptively. Dietary habits among respondents following a whole food plant‐based (WFPB) and vegan diet were compared using hypothesis tests.ResultsRespondents reported following a WFPB (61%), vegan (28%) and semi plant‐based (11%) diet. Median time on current dietary pattern was 5 years. Daily or more frequent consumption was reported for the following foods: fruits 77%, berries 51%, green vegetables 48%, cruciferous vegetables 45%, other vegetables 64%, beans/legumes 41%, whole grains 62%, nuts and all seeds 63%. Consumption of ultra‐processed foods and plant‐based meat alternatives was low. About 93% of those on a WFPB or vegan diet supplemented with vitamin B12 and 61% with vitamin D. The median body mass index was 22.4 kg/m2. Fifty per cent of participants reported weight loss after adopting a plant‐based diet, with a median loss of 6.4 kg. Thirty‐five per cent reported reversing or improving an underlying health condition, and 15% were able to stop or reduce prescribed medication use as a result of dietary changes.ConclusionsThis study suggests that a well‐planned plant‐based diet is achievable and sustainable in a community setting and can be associated with health benefits. How to best encourage such sustainable diets among the broad population requires further research.
Nonpharmacological interventions to improve the cognitive function among persons with traumatic brain injury: A systematic review
Authors: Chuaykarn Uraporn , Thato Ratsiri , Crago Elizabeth A. 
Published: May 2024

AbstractPurposeThe systematic review aimed to evaluate the effectiveness of nonpharmacological interventions (NPIs) for improving cognitive function among persons with traumatic brain injury.DesignA systematic review.MethodsThis systematic review was registered in PROSPERO and followed the PRISMA guideline. PubMed, ScienceDirect, Scopus, SpringerLink, Wiley Online Library, JSTOR, and Taylor & Francis were systematically searched for relevant articles of peer‐reviewed studies published between 2008 and 2022. Two independent researchers conducted study selection, data extraction, and data quality assessment.FindingsTwenty‐one studies met inclusion criteria, numbering a total of 757 participants. Six groups of NPIs were effective in improving cognitive functioning among persons with traumatic brain injury, including multimodal cognitive training, technology innovation, memory training, executive function training, physical activity, and sensory stimulation programs. Pooled evidence revealed that NPIs had a large effect on memory (d = 0.80, p < 0.05 to d = 2.03, p < 0.000), processing speed (d = 1.58, p < 0.05), and cognitive behavior (d = 1.63, p < 0.001 to d = 8.91, p 0.003). There was a medium effect on executive function (d = 0.5, p < 0.01 to d = 0.62, p < 0.05), attention (d = 0.5, p < 0.01), and intelligence (d = 0.57 to d = 0.59, p = 0.000). For visuospatial function and language, there was a significant increase post‐intervention.ConclusionEvidence from this systematic review indicates that NPIs, specifically the use of multimodal cognitive training and sensory stimulation programs, were effective in improving cognitive function outcomes among persons with traumatic brain injury, with medium to large effect sizes.Clinical RelevanceNonpharmacological interventions (NPIs) can enhance cognitive function in individuals with traumatic brain injury. These findings can guide healthcare professionals in clinical settings and support the development of technology applications for cognitive rehabilitation using NPIs.
Commitment and efforts to maintain mentoring: Nurse managers' perceptions of structuring mentoring provision for new nurses in a hospital setting
Authors: Berndtsson Pernilla , Skyvell‐Nilsson Maria , Brink Eva , Berghammer Malin 
Published: May 2024

AbstractAimThe aim of the present study was to describe nurse managers' perceptions of the provision of mentoring for newly graduated registered nurses (NGRNs) and its contribution to the work environment in a hospital setting.BackgroundNurse managers are responsible for the work environment and for supporting the staff's professional development, which includes giving NGRNs organizational support during their introduction to the workplace. Mentorship is one common way to provide support, but there is a lack of knowledge about how nurse managers view this support.Design/MethodThis was a qualitative descriptive study, using a semi‐structured interview guide. Fifteen individual interviews with nurse managers were performed in hospital settings. The interview transcripts were analysed using qualitative content analysis. The COREQ guidelines and checklist were used.ResultsThe results describe the nurse managers' perceptions of the provision of mentoring in three themes: Ensuring and sustaining mentoring for new nurses' needs is a struggle in the harsh reality of healthcare, Identifying mentors who are willing and possess the necessary competence for the assignment and Promoting a secure and attractive workplace by mentoring new nurses.ConclusionsOur study confirms that nurse managers are important in the provision of mentoring for NGRNs' learning and professional development. Mentoring has a positive spillover effect on the entire unit as a sustainable approach to securing and improving the work environment. Our study also identifies challenges for nurse managers to structure mentoring provision.Implications for the profession and/or patient careThis study highlights the importance of investment in mentoring for the NGRNs' professional development and for patient care. Support is needed from the top level of the organization, but how mentoring should be structured and facilitated needs to be investigated further.