bluuebunny/crossref_metadata_2025_split huggingface dataset:
ChemInform Abstract: Electrooxidative Cyclization of Hydroxyamino Compounds Possessing a Benzyl Group.
Authors: Okimoto Mitsuhiro , Ohashi Kousuke , Yamamori Haruki , Nishikawa Shinnosuke , Hoshi Masayuki , Yoshida Takashi 
Published: August 2012

AbstractElectrolytic oxidation of N‐benzyl‐2‐piperidine alcohols (I) and 3‐dialkylamino‐1‐phenylpropanols (III) is successfully developed to synthesize heminaminal type O,N‐heterocycles.
ChemInform Abstract: Highly cis‐Diastereoselective Synthesis of Coumarin‐Based 2,3‐Disubstituted Dihydrobenzothiazines by Organocatalysis.
Authors: Khoobi Mehdi , Ramazani Ali , Foroumadi Alireza , Emami Saeed , Jafarpour Farnaz , Mahyari Amir , Slepokura Katarzyna , Lis Tadeusz , Shafiee Abbas 
Published: August 2012

AbstractAn efficient synthesis of the title compounds (III), (V), and (VII) is presented by using the cheap and commercially available quinine hydrochloride as the catalyst of choice
ChemInform Abstract: The Design and Synthesis of Novel, Phosphonate‐Containing Transient Receptor Potential Melastatin 8 (TRPM8) Antagonists.
Authors: Matthews Jay M. , et al. et al. 
Published: August 2012

AbstractCompound (Ib) is identified as a highly selective and robust TRPM8 antagonist in vitro that inhibits icilin‐induced behaviors in a rat WDS model.
ChemInform Abstract: Palladium‐Catalyzed Asymmetric Allylic Alkylation of Electron‐Deficient Pyrroles with meso Electrophiles.
Authors: Trost Barry M. , Osipov Maksim , Dong Guangbin 
Published: August 2012

AbstractThe title reaction in the presence of ligands (I) allows the preparation of various nucleic acid precursors.
ChemInform Abstract: N‐Glycosylation of Enhanced Aromatic Sequons to Increase Glycoprotein Stability
Authors: Price Joshua L. , Culyba Elizabeth K. , Chen Wentao , Murray Amber N. , Hanson Sarah R. , Wong Chi‐Huey , Powers Evan T. , Kelly Jeffery W. 
Published: August 2012

AbstractReview: 102 refs.
Esterfication of Chlorocarboxylic Acids by Aqueous Hydrogenchloride – Influence on Kinetic and Conversion
Authors: Litzmann Oliver , Grützner Thomas , Hanselmann Paul , Heyl Andreas , Repke Jens‐Uwe 
Published: July 2012

AbstractEster der chlorierten Carboxylsäuren stellen wichtige Zwischenprodukte der Chemie dar. Im Rahmen dieser Arbeit wird untersucht, wie die Veresterung unter Ausnutzung der bei der Chlorierung anfallenden Salzsäure realisiert werden kann. Hierzu wird eine thermokinetische Messmethode zur Bestimmung der Kinetik entwickelt und der Einfluss der Mineralsäure auf den Reaktionsumsatz untersucht.
Oxidative Coupling of Methane: Process Design, Development and Operation in a Mini‐Plant Scale
Authors: Stünkel Steffen , Trivedi Harshil , Godini Hamid‐Reza , Jašo Stanislav , Holst Niko , Arndt Sebastian , Steinbach Jörg , Schomäcker Reinhard 
Published: August 2012

AbstractThe catalytic oxidative coupling of methane to higher hydrocarbons (OCM) is an alternative route for production of ethylene or liquid fuels and has obtained much attention in the past. In this article the process design of reactor concepts and the gas treatment of the product gas are discussed. In addition to the reaction engineering and thermal separation engineering aspects, the consideration of safety issues is included. In a case study, the OCM process is developed on a mini‐plant scale and first, preliminary experimental results are shown. The results of the accompanying safety study based on a HAZOP analysis are discussed for the whole OCM process. The energy savings by implementation of a hybrid separation process based on a membrane separation module and an absorption process for the CO2 removal from the OCM product is presented and validated experimentally on a mini‐plant scale.
The Use of Spray Nozzles for the Reduction of Fugitive Dust Emissions
Authors: Klenk Ulrich , Parey Matthias 
Published: July 2012

AbstractZur Entfernung von Staub aus Abgasströmen mittels Sprühdüsen werden u. a. Nasswäscher verwendet, die in einem definierten Volumenstrom einen definierten Sprüh erzeugen, um Partikeln möglichst effektiv und mit geringem Energieaufwand auszuwaschen. Tropfengröße, Druck und Wassermenge lassen sich an den Abgasstrom anpassen. Sollen jedoch Staubemissionen aus diffusen Quellen, z. B. im Schüttgutumschlag, reduziert werden, so sind im Gegensatz zum definierten Abgasvolumenstrom die für die Minderungswirkung wesentlichen Faktoren veränderlich. Eine Vielzahl von unterschiedlichen Bedüsungssystemen machte es notwendig, diese hinsichtlich ihrer staubmindernden Wirkungen bei der Anwendung im Schüttgutumschlag zu bewerten um später gezielt eine Auswahl für verschiedene Einsatzgebiete treffen zu können.
Process Model Utilization in the Process Life‐Cycle: an Industrial Case Study
Authors: Müller David , Kahrs Olaf , Höser Stefan , Arellano‐Garica Harvey 
Published: July 2012

AbstractDie durchgängige Nutzung von Prozessmodellen während des Prozesslebenszyklus – von der Entwicklung bis hin zum Anlagenbetrieb – ist seit Jahren ein angestrebtes Ziel in der Forschung und der industriellen Praxis. Die Reduktion des Modellierungsaufwands ist einer der wesentlichen Faktoren für den wirtschaftlichen Erfolg. An einem industriellen Fallbeispiel wird die Nutzung eines bestehenden stationären Prozessmodells des BASF SE Inhouse‐Simulators CHEMASIM für den Online‐Einsatz illustriert. Das Prozessmodell wird laufend mit Messdaten einer realen Chemieanlage aktualisiert und stellt damit eine Technologieplattform für die Echtzeit‐Optimierung und das Prozessmonitoring dar.
Global expression profiling of globose basal cells and neurogenic progression within the olfactory epithelium
Authors: Krolewski Richard C. , Packard Adam , Schwob James E. 
Published: July 2012

AbstractOngoing, lifelong neurogenesis maintains the neuronal population of the olfactory epithelium in the face of piecemeal neuronal turnover and restores it following wholesale loss. The molecular phenotypes corresponding to different stages along the progression from multipotent globose basal cell (GBC) progenitor to differentiated olfactory sensory neuron are poorly characterized. We used the transgenic expression of enhanced green fluorescent protein (eGFP) and cell surface markers to FACS‐isolate ΔSox2‐eGFP(+) GBCs, Neurog1‐eGFP(+) GBCs and immature neurons, and ΔOMP‐eGFP(+) mature neurons from normal adult mice. In addition, the latter two populations were also collected 3 weeks after olfactory bulb ablation, a lesion that results in persistently elevated neurogenesis. Global profiling of mRNA from the populations indicates that all stages of neurogenesis share a cohort of >2,100 genes that are upregulated compared to sustentacular cells. A further cohort of >1,200 genes are specifically upregulated in GBCs as compared to sustentacular cells and differentiated neurons. The increased rate of neurogenesis caused by olfactory bulbectomy had little effect on the transcriptional profile of the Neurog1‐eGFP(+) population. In contrast, the abbreviated lifespan of ΔOMP‐eGFP(+) neurons born in the absence of the bulb correlated with substantial differences in gene expression as compared to the mature neurons of the normal epithelium. Detailed examination of the specific genes upregulated in the different progenitor populations revealed that the chromatin modifying complex proteins LSD1 and coREST were expressed sequentially in upstream ΔSox2‐eGFP(+) GBCs and Neurog1‐eGFP(+) GBCs/immature neurons. The expression patterns of these proteins are dynamically regulated after activation of the epithelium by methyl bromide lesion. J. Comp. Neurol. 521:833–859, 2013. © 2012 Wiley Periodicals, Inc.
Controllable one‐step synthesis of CuO, Cu2O and Cu
Authors: Zhao J.G. , Yang S.H. , Yang S.G. 
Published: July 2012

AbstractIn the present report, CuO, Cu2O and Cu have been successfully synthesized through a facile, one‐step hydrothermal method at a relative low temperature by controlling only the concentration of citric acid. Compared with other synthetic methods, the present method is mild, high‐efficient and nontoxic. The crystal structure and morphology of the as prepared samples were characterized by X‐ray diffraction and scanning electron microscopy, respectively. The mechanism for the crystal phase and morphological changes with different citric acid concentrations were discussed. The possible reaction process of the synthesis was also studied on the basis of the experimental results. We hope that this facile, one‐step hydrothermal method could be used in controlling synthesis of other metals and metal oxides under appropriate experimental conditions.
Effect of exercise intensity and duration on capillary glucose responses in pregnant women at low and high risk for gestational diabetes
Authors: Ruchat S.‐M. , Davenport M. H. , Giroux I. , Hillier M. , Batada A. , Sopper M. M. , McManus R. , Hammond J.‐A. , Mottola M. F. 
Published: August 2012

AbstractBackgroundExercise may influence glucose metabolism during pregnancy. We examined the effect of exercise intensity and duration on capillary glucose responses in pregnant women at low and high risk for gestational diabetes mellitus (GDM) who followed a modified GDM meal plan.MethodsRandomization occurred at study entry (16–20 weeks' gestation) into a low‐intensity [30% heart rate reserve, low risk‐30%I, n = 12; high risk‐30%I, n = 11] or vigorous‐intensity (70% heart rate reserve, low risk‐70%I, n = 12; R‐70%I, n = 11) exercise program with similar nutritional control. Exercise consisted of walking three to four times a week, gradually increasing time from 25 to 40 min/session. Free‐living capillary glucose concentrations were measured once a week pre‐exercise and post‐exercise.ResultsCapillary glucose responses to exercise were strongly influenced by an interaction between GDM risk, exercise duration and exercise intensity (p = 0.006). Decreases in glucose concentrations were observed after 25 (4 ± 13%), 35 (21 ± 12%) and 40 min (15 ± 18%) of walking in high risk‐30%I women, with the most noticeable decline after 35 and 40 min. In the high risk‐70%I, glucose concentrations decreased significantly only after 25 (22 ± 14%) and 35 min (7 ± 23%) and increasing the exercise time attenuated glucose concentrations decline. In low risk women, regardless of exercise intensity and duration, decreases in glucose concentrations were significant and similar.ConclusionTo achieve the best decline in glucose concentrations, pregnant women who follow a modified GDM meal plan should walk for 25 min/session at vigorous intensity or for 35–40 min/session at low intensity if they are at risk for GDM and for at least 25 min at either low or vigorous intensity if they are at low risk for GDM. Copyright © 2012 John Wiley & Sons, Ltd.
Hitchhiking with forests: population genetics of the epiphytic lichenLobaria pulmonariain primeval and managed forests in southeasternEurope
Authors: Scheidegger Christoph , Bilovitz Peter O. , Werth Silke , Widmer Ivo , Mayrhofer Helmut 
Published: August 2012

AbstractAvailability of suitable trees is a primary determinant of range contractions and expansions of epiphytic species. However, switches between carrier tree species may blur co‐phylogeographic patterns. We identified glacial refugia in southeasternEurope for the tree‐colonizing lichenLobaria pulmonaria,studied the importance of primeval forest reserves for the conservation of genetically diverse populations and analyzed differences in spatial genetic structure between primeval and managed forests with fungus‐specific microsatellite markers. Populations belonged to either of two genepools or were admixed. Gene diversity was higher in primeval than in managed forests. At small distances up to 170 m, genotype diversity was lower in managed compared with primeval forests. We found significant associations between groups of tree species and twoL. pulmonariagenepools, which may indicate “hitchhiking” ofL. pulmonariaon forest communities during postglacial migration. Genepool B ofL. pulmonariawas associated withEuropeanBeech (Fagus sylvatica)and we can hypothesize that genepool B survived the last glaciation associated within the refuge ofEuropeanBeech on theCoastal andCentralDinarides. The allelic richness of genepool A was highest in the Alps, which is the evidence for a northern refuge ofL. pulmonaria. Vicariant altitudinal distributions of the two genepools suggest intraspecific ecological differentiation.
Synthesis of Vinyl Sulfoxide‐Modified Pent‐2‐enofuranosides and Hex‐2‐enopyranosides and Preliminary Studies of Their Reactivity
Authors: Atta Ananta Kumar , Dey Debanjana , Bhaumik Atanu , Manna Chinmoy , Pal Tarun K. , Pathak Tanmaya 
Published: July 2012

AbstractVinyl sulfoxide‐modified pent‐2‐enofuranosides and hex‐2‐enopyranosides have been synthesized by using a controlled oxidation of C‐3‐deoxy‐C‐3‐thioaryl furanosides and pyranosides, respectively, followed by mesylation of the C‐2‐hydroxyl group and elimination. In the furanose system, both diastereomers were formed in almost equal ratio, whereas the pyranose ring imposed diastereoselectivity of oxidation of the sulfur atom to produce only Ss isomers in good overall yields. Vinyl sulfoxide‐modified 2‐enofuranosides were treated with NaCH2NO2 to obtain C‐2 branched chain sugars. Furanosyl sulfoxides yielded products that were similar to the adducts obtained by treatment of the corresponding sulfones with nitromethane. The sulfinyl group in thepyranosides influenced the diastereoselectivity of addition to produce adducts that differed from the products obtained from the corresponding vinyl sulfones under similar reaction conditions.
Middle Permian sponge–microencruster bioherms in the Akiyoshi Limestone, SW Japan: implications for Late Palaeozoic reef evolution on mid‐Panthalassan atolls
Authors: Nakazawa Tsutomu , Ueno Katsumi , Fujikawa Masayuki 
Published: July 2012

Middle Permian lagoonal bioherms are described from mid‐Panthalassan atoll carbonates (Akiyoshi Limestone) in the Akiyoshi accretionary complex, SW Japan. The bioherms are composed of frame‐building sphinctozoan and inozoan sponges, together with encrusting organisms, including chaetetids, Shamovella, calcareous red algae, and other microbes. Of them, sphinctozoan sponges, Shamovella, and microbes (forming microbialites) are the most dominant. Chaetetids, which were predominant in the Early Pennsylvanian but rapidly decreased in the late Moscovian, are also common in these bioherms. Archaeolithoporella and bryozoans are rare, probably due to the low‐energy lagoonal environment.This sponge–microencruster community replaced the Gzhelian–Asselian Palaeoaplysina–microencruster community on the Akiyoshi atolls during the Sakmarian–Kubergandian interval. This drastic change in the reef‐building community type almost coincides with the rapid deglaciation of the Gondwanan ice sheet and superplume activity beneath the mid‐Panthalassan ocean. The prosperity of calcareous sponges was possibly controlled by environmental factors such as warming and eutrophication after the Gondwanan glaciation. Copyright © 2012 John Wiley & Sons, Ltd.
Dynamics of T‐cell infiltration during the course of ovarian cancer: The gradual shift from a Th17 effector cell response to a predominant infiltration by regulatory T‐cells
Authors: Fialová Anna , Partlová Simona , Sojka Luděk , Hromádková Hana , Brtnický Tomáš , Fučíková Jitka , Kocián Petr , Rob Lukáš , Bartůňková Jiřina , Špíšek Radek 
Published: August 2012

AbstractThe type of immune cells that are present within the tumor microenvironment can play a crucial role in the survival of patients. However, little is known about the dynamics of the tumor‐infiltrating immune cells during disease progression. We studied the immune cells that infiltrated the tumor tissues of ovarian cancer patients at different stages of disease. The early stages of development of ovarian carcinomas were characterized by a strong Th17 immune response, whereas in stage II patients, recruitment of high numbers of Th1 cells was observed. In disseminated tumors (Stages III–IV), we detected a dominant population of Helios+ activated regulatory T cells (Tregs) along with high numbers of monocytes/macrophages and myeloid dendritic cells (mDCs). Tumor‐infiltrating Tregs had markedly lower expression of CCR4 than circulating Tregs, and the numbers of tumor‐infiltrating Tregs significantly correlated with the levels of CCL22 in ovarian tumor cell culture supernatants, suggesting their recruitment via a CCR4/CCL22 interaction. CCL22 was mainly produced by tumor cells, monocytes/macrophages and mDCs in the primary ovarian tumors, and its expression markedly increased in response to IFNγ. Taken together, the specific recruitment of Tregs, probably triggered by inflammatory stimuli, leads to a significant immune suppression in the advanced stages of ovarian cancer.
MUTYH c.933+3A>C, associated with a severely impaired gene expression, is the first Italian founder mutation in MUTYH‐Associated Polyposis
Authors: Pin Elisa , Pastrello Chiara , Tricarico Rossella , Papi Laura , Quaia Michele , Fornasarig Mara , Carnevali Ileana , Oliani Cristina , Fornasin Alessio , Agostini Marco , Maestro Roberta , Barana Daniela , Aretz Stefan , Genuardi Maurizio , Viel Alessandra 
Published: August 2012

AbstractMUTYH variants are differently distributed in geographical areas of the world. In MUTYH‐associated polyposis (MAP) patients from North‐Eastern Italy, c.933+3A>C (IVS10+3A>C), a transversion causing an aberrant splicing process, accounts for nearly 1/5 of all mutations. The aim of this study was to verify whether its high frequency in North‐Eastern Italy is due to a founder effect and to clarify its impact on MUTYH transcripts and protein. Haplotype analysis and age estimate performed on members of eleven Italian MAP families and cancer‐free controls provided evidence that c.933+3A>C is a founder mutation originated about 83 generations ago. In addition, the Italian haplotype associated with the c.933+3A>C was also found in German families segregating the same mutation, indicating it had a common origin in Western Europe. Altogether c.933+3A>C and the two common Caucasian mutations p.Tyr179Cys and p.Gly396Asp represent about 60% of MUTYH alterations in MAP patients from North‐Eastern Italy, suggesting the opportunity to perform targeted molecular screening for these variants in the diagnostic setting. Expression analyses performed on lymphoblastoid cell lines supported the notion that MUTYH c.933+3A>C alters splicing causing the synthesis of a non functional protein. However, some primary transcripts escape aberrant splicing, producing traces of full‐length transcript and wild‐type protein in a homozygote; this is in agreement with clinical findings that suggest a relatively mild phenotypic effect for this mutation. Overall, these data, that demonstrate a founder effect and further elucidate the splicing alterations caused by the MUTYH c.933+3A>C mutation, have important implications for genetic counseling and molecular diagnosis of MAP.
Coparenting interactions observed by the prenatal lausanne trilogue play: An Italian replication study
Authors: Simonelli Alessandra , Bighin Mara , de Palo Francesca 
Published: August 2012

AbstractThe infant–parent interaction is the focus of interest on early interactive relational models in the triadic perspective. This approach considers the mother–father–child interaction as the matrix of early competences, which start to develop well before delivery. This theoretical approach has generated an observation paradigm, the Lausanne Trilogue Play (LTP; E. Fivaz‐Depeursinge & A. Corboz‐Warnery, 1999). The aim of the study was to investigate (a) the psychometric characteristics of coding of the prenatal LTP procedure and their comparison with the Lausanne validation studies and (b) the characteristics of triadic interactions during pregnancy. Ninety‐eight nonreferred, primiparous families were recruited at childbirth courses. In addition to validated questionnaires, observational data were collected at the seventh month of pregnancy in the prenatal LTP. The collected data show good reliability of the LTP coding and a consistent factorial structure in line with the Lausanne validation studies (C. Carneiro, A. Corboz‐Warnery, & E. Fivaz‐Depeursinge, 2006; N. Favez et al., 2006). The Structure of the Play and the Intuitive Parenting Behaviors Scales seem the most representative dimensions in the prenatal period. Coparental abilities during pregnancy represent an interactive matrix for the construction of early family relations and may be considered as protective factors in the child's development of early triadic interactive abilities.
Regulation of μ‐opioid type 1 receptors by microRNA134 in dorsal root ganglion neurons following peripheral inflammation
Authors: Ni J. , Gao Y. , Gong S. , Guo S. , Hisamitsu T. , Jiang X. 
Published: August 2012

AbstractBackgroundMOR1 is the main transcript of μ‐opioid receptor (MOR) gene, which represents a mandatory molecule for the analgesic effects of opioids and plays an important role in the pathology of inflammatory pain. MicroRNAs (miR) are non‐coding molecules that primarily modulate gene expression at the post‐transcriptional level in various pathophysiological conditions. Based on in silico analysis, an exact match to the seed sequence of miR‐134 was found in 3′‐untranslated region of MOR1. Given the important roles of MOR1 in pain modulation, the purpose of this study is to investigate whether miR‐134 can regulate the MOR1 following allodynia.MethodsUsing Freund's adjuvant (CFA)‐induced chronic inflammatory pain model, we investigated the expression profiles of miR‐134 and MOR1 in rat dorsal root ganglia (DRG) using quantitative real‐time polymerase chain reaction, in situ hybridization and immunohistochemistry, respectively. The relationship of miR‐134 and MOR1 expressions was analysed by linear regression. Luciferase assay was used to examine whether MOR1 was the target of miR‐134.ResultsOur results showed that miR‐134 expression level was inversely related to MOR1 expression. Down‐regulation of miR‐134 and up‐regulation of MOR1 in the same tissues after inflammatory pain were observed. Functional experiments showed that MOR1 expression in SH‐SY5Y cells was up‐regulated after inhibition of miR‐134, indicating that MOR1 was a target of miR‐134.ConclusionsOur present data suggested a model that miR‐134 participated in CFA‐induced inflammatory pain by balancing the expression of MOR1 in DRGs, which implied that miR‐134 may be a potential therapeutic target for the treatment of neuropathic pain including inflammation.