bluuebunny/crossref_metadata_2025_split huggingface dataset:
Normal Conjunctival Flora
Authors: Javed Ejaz Ahmad , Sultan Muhammad , Mehmood Rana Qaisar 
Published: May 2024

Objective: To determine the prevalence of normal conjunctival flora and its types. Study Design: An observational study. Place And Duration of Study: At Ophtha-lmological Department, DHQ/Allied Hospital, PMC, Faisalabad, from November 2006 to February 2007. Patients And Methods: This study was performed on 500 patients, aged form 20 years to 70 years with normal looking eyes. The samples of sterile stuart’s swab were made on conjunctiva of patients, without touching eyelashes or lid margins. The swabs were touched with conjunctiva of both eyes and placed in stuart’s transparent media to shift to microbiological laboratory. Results: Out of 500 swabs 412 (82.4%) showed no growth while 78 (15.6%) showed microbial growth. Out of these 78 swabs, there were 44 (56.41%) having normal flora, while 34 (43.59%) had other pathogens. Conclusion: The normal looking eyes harbour different types of the organisms. Any trauma, accidental hurt or elective surgical procedure is not free from risk of conjunctival infection, keratits or endophthalmitis etc.
PENINGKATAN KAPASITAS DALAM PENGELOLAAN BUKU BESAR PEMBANTU UNTUK GURU SMA/SMK DI WILAYAH BREGASLANG (BREBES, TEGAL, SLAWI DAN PEMALANG)
Authors: Priatna Yeni , Kartika Dewi , Krisdiawati Krisdiawati , Yasmin Arifia , Nurkhasanah Ayu , Mayasari Dhea Windhi 
Published: May 2024

Para guru baik di SMA/SMK saat ini perlu mempersiapkan diri untuk menghadapi tantangan serta perkembangan teknologi dengan melakukan peningkatan pengetahuan dan keterampilan, untuk menguji tingkat kompetensi dapat dibuktikan dengan sertifikat kompetensi. Sertifikat kualifikasi merupakan pengakuan atas keterampilan dan pengetahuan seseorang, serta sikap kerja yang sesuai dengan standar keterampilan kerja yang dipersyaratkan. Politeknik Harapan Bersama merupakan perguruan tinggi yang melaksanakan pendidikan vokasi dimana salah satu program studinya adalah Diploma III Akuntansi. Program Studi DIII Akuntansi melaksanakan program Pengabdian kepada Masyarakat (PKM) dalam rangka mempersiapkan kompetensi guru serta meningkatkan kompetensi guru dalam rangka uji kompetensi klaster Pengelolaan Buku Besar Pembantu bagi para guru jurusan akuntansi di wilayah Bregaslang (Brebes, Tegal, Slawi, dan Pemalang).
Kata kunci: Buku besar pembantu, peningkatan ketrampilan dan kompetensi guru.
Teaching foreign languages in Poland – the ongoing search for efficient ways
Authors: Ponikarovska Svitlana 
Published: May 2024

Problem. The dynamic development of international relations and globalization determined the priority of knowledge of a foreign language by a specialist along with professional knowledge and social skills. Ukraine is at a new stage of development of relations with EU countries and the world. The country faces a very important and difficult task - to defeat the enemy. And only later, and too simultaneously, to learn to live, work, and provide education in accordance with world standards. Among the EU countries, there are countries that were in a similar position until recently, but they have long been full members of the European and world community. We have a lot to learn from such countries. We must use their experience and take into account mistakes. Among the countries that recently joined the European Community, Poland is a country that is geographically close to us, has a similar history, close ties with Ukraine, including in educational programs and student exchange. Goal. The purpose of the article is to analyze the peculiarities of foreign language learning in Polish educational institutions, noting the period of change in the country's development strategy, to dermine the differences and similarities between the Polish and Ukrainian foreign language teaching systems and to analyze the impact of teacher training on the quality of foreign language teaching. Methodology. The purpose and specificity of the study determined the use of the method of description with elements of comparative analysis for a comprehensive coverage of the issue. Results. The article showed the stages of evolution in teaching foreign languages in Poland during the years of its development, especially after joining the democratic institutions. Originality. The is an analysis of the language teaching methodology development. Those whom this subject concerns may find it interesting to go deep into the history and follow the analysis of old and new practices in the subject. Practical value. Certain issues in the article can help the teachers understand the challenges and goals of teaching languages in today’s world.
Selectivity and Sensitivity of Multi-Walled Carbon Nanotubes for NO2 Gas Sensor
Authors: Makram Nisreen 
Published: May 2024

The flexible gas sensor was fabricated using functionalized multi-walled carbon nanotubes (MWCNTs-OH) suspension deposited on filter cake by employing the filtration from suspension (FFS) method and embedded with (polyaniline and polypyrrole) nanoparticles (PANI, PPy) NPs. MWCNTs-OH network showed a decrease in resistance upon exposure to the NO2 gas in comparison with air. The structural and morphological characteristics of the film were investigated using (XRD), (AFM) and (SEM ). The sensitivity was measured for the fabricated gas sensor at room temperature pure and embedded lattice with metallic nanoparticles after exposure to NO2 gas at concentration of about 25 ppm. The results revealed that the sensitivity increases when doped with PANI and PPy NPs.
Hubungan Self-Management dengan Burnout Akademik Siswa dalam Pembelajaran di Era New Normal
Authors: Rahmawati Alivia , Firman Firman 
Published: May 2024

Penelitian ini dilatarbelakangi oleh adanya siswa yang merasa bosan dan jenuh dengan sistem pembelajaran yang diberlakukan saat ini yaitu pembelajaran peralihan yang disesuaikan dengan protokol covid-19 yang disebut era new normal. Salah satu faktor yang memengaruhi burnout akademik adalah self-management. Penelitian ini merupakan penelitian deskriptif-korelasional. Penelitian ini menggunakan populasi siswa SMAS Adabiah Padang sebanyak 786 siswa dengan sampel penelitian sebanyak 266 siswa yang diambil menggunakan teknik stratified random sampling. Pengumpulan data menggunakan skala model Likert. Data dianalisis dengan teknik statistik deskriptif, korelasional Pearson Product Moment dengan bantuan SPSS 23. Hasil penelitian ini menunjukan bahwa terdapat hubungan yang signifikan dan negatif antara self-management dengan burnout akademik siswa dengan nilai koefisien korelasi sebesar -0,658 dan signifikansi 0,000. Implikasi hasil penelitian terhadap BK yaitu dengan memberikan layanan informasi, layanan konseling kelompok dan layanan bimbingan kelompok.
Perbandingan Kemampuan Pemahaman Matematika Antara Siswa Yang Mendapatkan Pembelajaran Contextual Teaching And Learning (CTL) Dan Metakognitif
Authors: Al-Siyam Egi , Sundayana Rostina 
Published: May 2024

This research is based on the fact that the understanding abilities of student mathematics o is low. The Purpose of this research was to know the mathematics comparison result mathematics understanding ability between the students get Contextual Teaching and Learning (CTL) and metacognitive. The research method is used quasi experiment, with a significant level of 1%. After perform posttest of can take by conclusion that mathematics understanding ability between students’ who getting Contextual Teaching and Learning (CTL) as the same ability degree as metacognitive learning.
Penelitian ini dilakukan berdasarkan adanya fakta bahwa kemampuaan pemahaman matematika siswa masih rendah. Tujuan penelitian ini adalah untuk mengetahui hasil perbandingan kemampuan pemahaman matematika antara siswa yang mendapatkan pembelajaran Contextual Teaching and Learning (CTL) dengan Metakognitif. Metode penelitian yang digunakan adalah kuasi eksperimen, dengan taraf signifikan 1%. Setelah melakukan tes akhir dapat diambil kesimpulan kemampuan pemahaman matematika antara siswa yang mendapatkan pembelajaran Contextual Teaching and Learning (CTL) mempunyai tingkat kemampuan yang sama dengan siswa yang mendapatkan pembelajaran Metakognitif.
Implementasi Pendekatan Semantic Object Model Pada Rancangan Database Penatausahaan Aset Fasilitas Kantor
Authors: Bariah Siti Husnul 
Published: May 2024

Database merupakan salah satu komponen yang paling penting dalam sebuah sistem informasi, karena merupakan dasar dalam menyediakan informasi atau kumpulan data yang ditampilkan melalui sistem informasi. Hasil analisis terhadap proses penatausahaan sebelumnya terdapat beberapa kekurangan dantaranya membutuhkan sebuah perangkat lunak yang terkomputerisasi, dan hal itu tidak terlepas dari adanya suatu database yang berfungsi sebagai media penyimpanan yang berhubungan dengan aplikasi yang ada. Pada penelitian ini penyusun menerapkan pendekatan Semantic Object Model dalam pemodelan datanya, yang dalam merepresentasikan objek-objeknya menggunakan diagram SOM. Pemodelan data dengan menggunakan Semantic Objet Model dapat memudahkan pengembang dalam mengimplementasikan model data tersebut karena, Semantic Object Model lebih detail dalam penggambaran model datanya, sehingga untuk melakukan proses selanjutnya yaitu pembuatan relational database lebih mudah.
A Revolution in Sustainable Development
Authors: Henrique Sannibale  
Published: May 2024

The way we are currently developing our building structures is unsustainable, with a large amount of greenhouse gas (GHGs) emissions being a direct result of the production and implementation of the materials used in our buildings.
The purpose of this honors thesis is to better understand the potential and feasibility of hemp biocomposite materials in construction. A case study will be examined, where a house plan will be taken, and utilized in two homes, one being constructed with conventional materials such as lumber, while the other with hemp biocomposites. Because the same house plan is used in both homes, we can objectively quantify the carbon footprint and monetary cost of both dwellings, and directly compare them. This side by side analysis can allow developers, architects, and hemp-based construction material companies to see the difference in cost and carbon footprint associated with switching to hemp biobased materials.
Using professional journals, peer reviewed literature, and interviews with hemp companies, a building product analysis was conducted. This section shows the advantages and potential drawbacks of current building materials, and what are the benefits and drawbacks of transitioning towards hemp biocomposites. Through the building analysis and case study, this thesis is an extensive tool that shows the potential of hemp in future residential home construction.
The carbon sequestered through hemp biocomposites is nearly double its conventional counterparts, and its higher cost can be justified as its benefits could be argued to outweigh the difference in total cost when it comes to the price of the home.
For the full text, please visit https://scholar.colorado.edu/concern/undergraduate_honors_theses/rx913r48x.
The impact of disc degeneration on the dynamic characteristics of the lumbar spine: a finite element analysis
Authors: Wang Xue , Liu Wei , Zhao Yaqiong , Ma Pengcheng 
Published: May 2024

The dynamics of disc degeneration was analyzed to determine the effect of disc degeneration at the L4-L5 segment on the dynamic characteristics of the total lumbar spine. A three-dimensional nonlinear finite element model of the L1-S1 normal lumbar spine was constructed and validated. This normal model was then modified to construct two degeneration models with different degrees of degeneration (mild, moderate) at the L4-L5 level. Modal analysis, harmonic response analysis, and transient dynamics analysis were performed on the total lumbar spine when experiencing following compressive loading (500 N). As the degree of disc degeneration increased, the vibration patterns corresponding to the first three orders of the model’s intrinsic frequency were basically unchanged, with the first order being in the left-right lateral bending direction, the second order being in the forward-flexion and backward-extension direction, and the third order being in the axial stretching direction. The nucleus pulposus pressure peaks corresponding to the first order intrinsic frequency for the harmonic response analysis are all on the right side of the model, with sizes of 0.053 MPa, 0.061 MPa, and 0.036 MPa, respectively; the nucleus pulposus pressure peaks corresponding to the second order intrinsic frequency are all at the rear of the model, with sizes of 0.13 MPa, 0.087 MPa, and 0.11 MPa, respectively; and the nucleus pulposus pressure peaks corresponding to the third order intrinsic frequency are all at the front of the model, with sizes of 0.19 MPa, 0.22 MPa, and 0.22 MPa, respectively. The results of the transient analysis indicated that over time, the response curves of the healthy model, the mild model, and the moderate model all exhibited cyclic response characteristics. Intervertebral disc degeneration did not adversely affect the vibration characteristics of the entire lumbar spine system. Intervertebral disc degeneration significantly altered the dynamics of the degenerative segments and their neighboring normal segments. The process of disc degeneration gradually shifted the load from the nucleus pulposus to the annulus fibrosus when the entire lumbar spine was subjected to the same vibratory environment.
Analysis of transient characteristics and design improvement of the passive residual heat removal system of NHR-200-II
Authors: Yiwa Geng , Xiongbin Liu , Ziyi Li , Shuliang Huang , Lanyu Zhou , Yanfang Xue , Xiaotian Li , Yajun Zhang 
Published: May 2024

NHR-200-II is a small integrated pressurized water reactor with 200 MW core thermal power. The core heat is transferred to two independent intermediate circuits via fourteen in-vessel primary heat exchangers (PHE), and the heat in the intermediate circuits is transferred to feedwater by two steam generators (SG) in the two intermediate circuits respectively. A passive residual heat removal (PRHR) branch is connected to each intermediate circuit to remove core decay heat under postulated accidents. During normal operation, PRHR branches are isolated by valves while SG branches in intermediate circuits are open. The valves in PRHR branches will be opened and the isolation valves of SG branches will be closed during decay heat removal scenarios. The decay heat removal capacity of NHR-200-II PRHRS could be seriously deteriorated once the isolation valves for SG branches fail to close, which was confirmed in a scaled integral test loop previously. Current understanding of PRHRS’s thermal-hydraulic characteristics with possible isolation failure in SG branches is limited. In this paper, the NHR-200-II PRHRS is modeled with RELAP5 considering the case of success and fail to isolate SG branches. A series of numerical simulations are carried out to study the impact of various parameters, such as the initial temperature, the size of the intermediate circuits’ header, and the initial flow direction in the intermediate circuits. Oscillatory flow is found when SG branches fail to be isolated under certain parameters combinations. An improved PRHRS design is purposed to eliminate possible flow oscillations, and the purposed improved design are tested by numerical simulations.
Association between migraine and venous thromboembolism: a Mendelian randomization and genetic correlation study
Authors: Wu Xu-Peng , Niu Peng-Peng , Liu Hong 
Published: May 2024

ObjectivePrevious observational studies have reported an increased risk of venous thromboembolism (VTE) among individuals with migraine. This study aimed to investigate the causal effect of migraine on the development of VTE, as well as explore the genetic correlation between them.MethodsWe conducted a two-sample Mendelian randomization (MR) study using publicly available summary statistics from large-scale genome-wide association studies for migraine and VTE. Linkage disequilibrium score regression analysis was performed to estimate the genetic correlation between migraine and VTE.ResultsThere were several shared risk variants (p-value &lt; 5 × 10−8) between migraine and VTE. Linkage disequilibrium score regression analysis found a significant positive genetic correlation between migraine and VTE. The genetic correlations based on two migraine datasets were 0.208 (se = 0.031, p-value = 2.91 × 10−11) and 0.264 (se = 0.040, p-value = 4.82 × 10−11), respectively. Although main MR analysis showed that migraine was associated with an increased risk of VTE (odds ratio = 1.069, 95% confidence interval = 1.022–1.118, p-value = 0.004), the association attenuated to non-significance when using several other MR methods and using another set of genetic instruments. In addition, evidence of heterogeneity was found. Reverse MR analysis showed VTE was associated with increased risk of migraine with aura (odds ratio = 1.137, 95% confidence interval = 1.062–1.218, p-value = 2.47 × 10−4) with no evidence of pleiotropy and heterogeneity.ConclusionWe showed suggestive evidence indicating an association between migraine and increased risk of VTE. Additionally, we found robust evidence suggesting that VTE is associated with an increased risk of migraine. The positive genetic correlation indicates that migraine and VTE has shared genetic basis. Further investigations will be necessary to address potential sex-specific effects in the analysis.
Exercise for frailty research frontiers: a bibliometric analysis and systematic review
Authors: Xu Wenyuan , Zhao Xianghu , Zeng Meiling , Wu Shengbing , He Yikang , Zhou Meiqi 
Published: May 2024

BackgroundExercise intervention is a method of improving and preventing frailty in old age through physical exercise and physical activity. It has a positive impact on many chronic diseases and health risk factors, in particular cardiovascular disease, metabolic disease, osteoporosis, mental health problems and cancer prevention, and exercise therapies can also fight inflammation, increase muscle strength and flexibility, improve immune function, and enhance overall health. This study was aimed to analyze research hotspots and frontiers in exercise therapies for frailty through bibliometric methods.MethodsIn this study, data of publications from 1st January 2003 to 31st August 2023 were gathered from the Web of Science Core Collection and analyzed the hotspots and frontiers of frailty research in terms of remarkable countries/regions, institutions, cited references, authors, cited journals, burst keywords, and high-frequency keywords using CiteSpace 6.2.R3 software. The PRISMA reporting guidelines were used for this study.ResultsA collection of 7,093 publications was obtained, showing an increasing trend each year. BMC Geriatrics led in publications, while Journals of Gerontology Series A-Biological Sciences and Medical Sciences dominated in citations. The United States led in centrality and publications, with the University of Pittsburgh as the most productive institution. Leocadio R had the highest publication ranking, while Fried Lp ranked first among cited authors. Keywords in the domain of exercise therapies for frailty are “frailty,” “older adult,” “physical activity,” “exercise,” and “mortality,” with “sarcopenia” exhibiting the greatest centrality. The keywords formed 19 clusters, namely “#0 older persons,” “#1 mortality,” “#2 muscle strength,” “#3 bone mineral density,” “#4 muscle mass,” “#5 older adults,” “#6 older people,” “#7 women’s health,” “#8 frail elderly,” “#9 heart failure,” “#10 geriatric assessment,” “#11 comprehensive geriatric assessment,” “#12 outcm,” “#13 alzheimers disease,” “#14 quality of life,” “#15 health care,” “#16 oxidative stress,” “#17 physical activity,” and “#18 protein.”ConclusionThis study presents the latest developments and trends in research on frailty exercise intervention treatments over the past 20 years using CiteSpace visualization software. Through systematic analyses, partners, research hotspots and cutting-edge directions were revealed, providing a guiding basis for future research.
Comprehensive analysis of juvenile idiopathic arthritis patients’ immune characteristics based on bulk and single-cell sequencing data
Authors: Liu Mubo , Gong Yadong , Lin Mu , Ma Qingqing 
Published: May 2024

Background:The pathogenesis of juvenile idiopathic arthritis (JIA) is strongly influenced by an impaired immune system. However, the molecular mechanisms underlying its development and progression have not been elucidated. In this study, the computational methods TRUST4 were used to construct a T-cell receptor (TCR) and B-cell receptor (BCR) repertoire from the peripheral blood of JIA patients via bulk RNA-seq data, after which the clonality and diversity of the immune repertoire were analyzed.Results:Our findings revealed significant differences in the frequency of clonotypes between the JIA and healthy control groups in terms of the TCR and BCR repertoires. This work identified specific V genes and J genes in TCRs and BCRs that could be used to expand our understanding of JIA. After single-cell RNA analysis, the relative percentages of CD14 monocytes were significantly greater in the JIA group. Cell-cell communication analysis revealed the significant role of the MIF signaling pathway in JIA.Conclusion:In conclusion, this work describes the immune features of both the TCR and BCR repertoires under JIA conditions and provides novel insight into immunotherapy for JIA.
Unraveling breast cancer prognosis: a novel model based on coagulation-related genes
Authors: Lei Chuqi , Li Yuan , Yang Huaiyu , Zhang Ke , Lu Wei , Wang Nianchang , Xuan Lixue 
Published: May 2024

ObjectiveBreast cancer is highly heterogeneous, presenting challenges in prognostic assessment. Developing a universally applicable prognostic model could simplify clinical decision-making. This study aims to develop and validate a novel breast cancer prognosis model using coagulation-related genes with broad clinical applicability.MethodsA total of 203 genes related to coagulation were obtained from the KEGG database, and the mRNA data of 1,099 tumor tissue samples and 572 samples of normal tissue were retrieved from the TCGA-BRCA cohort and GTEx databases. The R package “limma” was utilized to detect variations in gene expression related to coagulation between the malignancies and normal tissue. A model was constructed in the TCGA cohort through a multivariable Cox regression analysis, followed by validation using the GSE42568 dataset as the testing set. Constructing a nomogram incorporating clinical factors to enhance the predictive capacity of the model. Utilizing the ESTIMATE algorithm to investigate the immune infiltration levels in groups with deferent risk. Performing drug sensitivity analysis using the “oncoPredict” package.ResultsA risk model consisting of six coagulation-associated genes (SERPINA1, SERPINF2, C1S, CFB, RASGRP1, and TLN2) was created and successfully tested for validation. Identified were 6 genes that serve as protective factors in the model’s development. Kaplan-Meier curves revealed a worse prognosis in the high-risk group compared to the low-risk group. The ROC analysis showed that the model accurately forecasted the overall survival (OS) of breast cancer patients at 1, 3, and 5 years. Nomogram accompanied by calibration curves can also provide better guidance for clinical decision-making. The low-risk group is more likely to respond well to immunotherapy, whereas the high-risk group may show improved responses to Gemcitabine treatment. Furthermore, individuals in distinct risk categories displayed different responses to various medications within the identical therapeutic category.ConclusionWe established a breast cancer prognostic model incorporating six coagulation-associated genes and explored its clinical utility. This model offers valuable insights for clinical decision-making and drug selection in breast cancer patients, contributing to personalized and precise treatment advancements.