bluuebunny/crossref_metadata_2025_split huggingface dataset:
CAR-T Therapy Followed by Hematopoietic Stem Cell Transplantation Can Improve Survival in Children Relapsed/Refractory Philadelphia Chromosome–positive B-cell Acute Lymphoblastic Leukemia
Authors: Li Yao , Hu Guan-Hua , Xu Lan-Ping , Zhang Xiao-Hui , Liu Kai-Yan , Suo Pan , Wang Yu , Cheng Yi-Fei , Huang Xiao-Jun 
Published: April 2024

Background:
Philadelphia chromosome (Ph)-positive B-cell acute lymphoblastic leukemia (ALL) has a high complete remission (CR) rate, but relapse and prolonged measurable residual disease remain serious problems. We sought to describe the CR rate measurable residual disease negative rate and address the results and safety of pediatric patients who underwent after receiving chimeric antigen receptor (CAR) specific for CD19 (CAR-19) followed by hematopoietic stem cell transplantation (HSCT) for the treatment of Ph-positive ALL.

Methods:
A descriptive study was conducted at Peking University People’s Hospital from September 2013 to January 2021. 13 patients with relapsed/refractory Ph-positive B-ALL who received CAR-T therapy followed by allo-HSCT were included. We concentrated on the overall patient survival and CR rate.

Results:
The median time between CAR-T therapy and allo-HSCT was 58 days. Among all the patients, the CR rate was 100%, the flow cytometry negativity rate was 84.62%, and the BCR-ABL negativity rate was 53.85% at 1 month after CAR-T infusion. All the patients achieved a major molecular response in 6 months after HSCT. After a median follow-up of 45 months, the 3-year OS rate was 66.7%, and the 3-year DFS rate was 61.5%. The 3-year OS rate of patients with BCR-ABL-positive pre-HSCT was significantly lower than that in the BCR-ABL-negative group (40.0% vs. 85.7%, P=0.042). Also, the same trend was observed for the 3-year DFS rate but did not differ significantly (40.0% vs. 75.0%, P=0.233).

Conclusions:
CAR-T therapy followed by allo-HSCT can be a safe and effective treatment for Ph-positive B-ALL pediatric patients.
A Comparison of Two Debriefing Rubrics to Assess Facilitator Adherence to the PEARLS Debriefing Framework
Authors: Guimbarda Nick , Boghani Faizan , Tews Matthew , Kleinheksel A. J. 
Published: April 2024

Introduction
Many educators have adopted the Promoting Excellence and Reflective Learning in Simulation (PEARLS) model to guide debriefing sessions in simulation-based learning. The PEARLS Debriefing Checklist (PDC), a 28-item instrument, and the PEARLS Debriefing Adherence Rubric (PDAR), a 13-item instrument, assess facilitator adherence to the model. The aims of this study were to collect evidence of concurrent validity and to evaluate their unique strengths.

Methods
A review of 130 video recorded debriefings from a synchronous high-fidelity mannequin simulation event involving third-year medical students was undertaken. Each debriefing was scored utilizing both instruments. Internal consistency was determined by calculating a Cronbach's α. A Pearson correlation was used to evaluate concurrent validity. Discrimination indices were also calculated.

Results
Cronbach's α values were 0.515 and 0.714 for the PDAR and PDC, respectively, with ≥0.70 to ≤0.90 considered to be an acceptable range. The Pearson correlation coefficient for the total sum of the scores of both instruments was 0.648, with a values between ±0.60 and ±0.80 considered strong correlations. All items on the PDAR had positive discrimination indices; 3 items on the PDC had indices ≤0, with values between −0.2 and 0.2 considered unsatisfactory. Four items on both instruments had indices >0.4, indicating only fair discrimination between high and low performers.

Conclusions
Both instruments exhibit unique strengths and limitations. The PDC demonstrated greater internal consistency, likely secondary to having more items, with the tradeoff of redundant items and laborious implementation. Both had concurrent validity in nearly all subdomains. The PDAR had proportionally more items with high discrimination and no items with indices ≤0. A revised instrument incorporating PDC items with high reliability and validity and removing those identified as redundant or poor discriminators, the PDAR 2, is proposed.
Telemedicine in geriatric oncology – lessons learned from the COVID-19 experience
Authors: Cabrera Chien Leana , Uranga Carolina , Katheria Vani 
Published: April 2024

Purpose of review
Telemedicine quickly became integrated into healthcare caused by the Coronavirus 19 (COVID-19) pandemic. Rapid use of telemedicine into healthcare systems was supported by the World Health Organization and other prominent national organizations to reduce transmission of the virus while continuing to provide access to care. In this review, we explored the effect of this swift change in care and its impact on older adults with cancer.

Recent findings
Older adults are susceptible to the COVID-19 virus caused by various risk factors, such as comorbidity, frailty, decreased immunity, and cancer increases vulnerability to infection, hospitalization, and mortality. We found three major themes emerged in the literature published in the past 18 months, including access to care, telemedicine modes of communication, and the use of technology by older adults with cancer. These findings have brought insight into issues regarding healthcare disparities.

Summary
The utilization of telemedicine by older adults with cancer has potential future benefits with the integration of technology preparation prior to the patient’s initial visit and addressing known health disparities. The hybrid model of care provides in-person and or remote access to clinicians which may allow older adults with cancer the flexibility needed to obtain quality cancer care.
Improving supportive, palliative and end of life care for teenagers and young adults with cancer in adult haematology services
Authors: Lewis-Norman Claire , Vidrine Jennifer , Thistlethwayte Emma 
Published: April 2024

Purpose of review
Adolescents with haematological malignancies within adult services, in the UK from 16 years old, have unique needs and require developmentally targeted services and approaches to care delivery. High-risk intensive treatments are common for this cohort and a better understanding of what individualised supportive and palliative care means in this context is required.

Recent findings
Being known and understood as an emerging adult, with particular recognition of developmental stage, is an essential component of quality measures and underpins the adolescent, and caregiver, experience when faced with an uncertain or poor cancer prognosis (UPCP). Healthcare professionals (HCPs) can experience increased emotional labour and feelings of professional inadequacy when caring for adolescents with UPCP. Therapeutic alliance improves HCPs understanding of optimum individualised care by improving communication and supported decision making. Access to training and support for HCPs is required to address the emotional impact of therapeutic alliance with teenage/adolescent and young adults (T/AYAs) with advanced cancer.

Summary
Investment in therapeutic alliance, alongside robust support mechanisms and targeted training, can improve the skills, confidence and wellbeing for HCPs, and can also ensure optimum individualised care for T/AYAs with UPCP. Evidence for optimum care for adolescents with advanced cancer is relatively scarce, especially for younger T/AYAs (16–24) in the UK who sit within adult services. Further evaluation of the impact of current UK expertise, services and programs are needed to inform future development.
Supportive care measures for bispecific T-cell engager therapies in haematological malignancies
Authors: Chen Lucia Y. , Kothari Jaimal 
Published: April 2024

Purpose of review
Bispecific T-cell engager (TCE) therapies are revolutionising the treatment of several haematological malignancies, including B-cell acute lymphoblastic leukaemia, various subtypes of B-cell non-Hodgkin lymphoma, and multiple myeloma. Due to their unique mode of action in activating endogenous T cells, they are associated with several important early side effects, including cytokine release syndrome and immune effector cell-associated neurotoxicity syndrome. In addition, TCEs can cause target-specific toxicities and carry a significant risk of infection.

Recent findings
Currently, supportive care measures for TCEs have largely been inferred from other T-cell therapies, such as CAR-T (chimeric antigen receptor) therapy. Further research into TCE-specific supportive care measures is needed to improve the tolerability of these therapies for patients. A key question moving forward is understanding how to predict and minimise early toxicity (cytokine release syndrome and immune effector cell-associated neurotoxicity syndrome). Associated infection risk is a significant cause of patient morbidity, therefore a better understanding of how to optimise TCE-dosing and prophylactic measures, such as intravenous immunoglobulin and antimicrobials, will be crucial to achieving an improved balance of toxicity and efficacy. Enabling early outpatient delivery of these therapies to select patients at lower risk of toxicity may also help to improve patient experience and quality of life.

Summary
Here we review up-to-date guidance and literature on existing supportive care measures for bispecific TCE therapy-related toxicities. We highlight both unique and serious side effects of TCE therapies that require improved management strategies to enable more patients to benefit from these efficacious drugs.
Gastrointestinal mucositis: a sign of a (systemic) inflammatory response
Authors: Blijlevens Nicole M.A. , Reijnders Björn , Molendijk Eva 
Published: April 2024

Purpose of review
Gastrointestinal mucositis (GIM) is a significant complication of cancer therapy. Whilst inflammation is a central feature of GIM, studies attempting to mitigate mucosal damage via this mechanism are scarce. This review describes the relation between GIM, local and systemic inflammation, and the microbiome and its metabolites, and explores recent research on therapeutics that target this relationship.

Recent findings
Recent literature underscores the pivotal role of inflammation in GIM, elucidating its bidirectional relation with disturbance of the gut microbiota composition and intestinal permeability. These events cause a heightened risk of bloodstream infections and lead to systemic inflammation. While studies investigating risk prediction models or therapeutics targeting GIM-related inflammation remain scarce, results have shown promise in finding biomarkers and alleviating GIM and its accompanying clinical symptoms.

Summary
The findings underscore the important role of inflammation and the microbiome in GIM. Understanding the inflammatory pathways driving GIM is crucial for developing effective treatments. Further research is needed using genomics, epigenomics, and microbiomics to explore better risk prediction models or therapeutic strategies aimed at mitigating GIM-related inflammation.
The gatekeeper to gastric cancer; gastric microbiota invade the lamina propria inHelicobacter pylori-associated gastric carcinogenesis
Authors: Giddings Harriet J. , Teodósio Ana , McMurray Jack L. , Hunter Kelly , Abdawn Zainab , Cole Jeffrey A. , Shannon-Lowe Claire D. , Rossiter-Pearson Amanda E. 
Published: April 2024

AbstractStomach cancer is the fourth leading cause of cancer-related deaths worldwide.Helicobacter pyloriis the main risk factor for gastric adenocarcinoma (GAC), yet the mechanism underpinning this association remains uncharacterised. Gastric intestinal metaplasia (GIM) represents the pre-cancerous stage and followsH. pylori-associated chronic gastritis (CG). Sequencing studies have revealed fewerH. pyloriand more non-H. pyloribacteria in GAC. However, the spatial organisation of the gastric microbiota in health and disease is unknown. Here, we have combined RNAin situhybridisation and immunohistochemistry to detectH. pylori, non-H. pyloribacteria and host cell markers (E-cadherin, Mucins 5AC and 2) from patients with CG (n=9), GIM (n=12), GAC and normal tissue adjacent to tumours (NATs) (n=3). Quantitative analysis of whole slide scans revealed significant correlations ofH. pyloriand other bacteria in CG and GIM samples. In contrast to sequencing studies, significantly fewer non-H. pyloribacteria were detected inH. pylori-negative patients. Importantly, whilstH. pyloriexclusively colonised the gastric glands, non-H. pyloribacteria invaded the lamina propria in 3/4 CG and 5/6 GIMH. pylori-positive patients. Bacterial invasion was observed in 3/3 GAC samples and at higher levels than matched NATs. We propose thatH. pylori‘holds the keys’ to disrupt the gastric epithelial barrier, facilitating the opportunistic invasion of non-H. pyloribacteria to the lamina propria. Bacterial invasion could be a significant driver of inflammation inH. pylori-associated carcinogenesis. This proposed mechanism would both explain the synergistic roles ofH. pyloriand other bacteria and redirect attempts to prevent, diagnose and treat GAC.
Reduced cross sections of electron and neutrino charged current quasielastic scattering on nuclei
Authors: Butkevich A. V. 
Published: April 2024

The semiexclusive averaged reduced cross sections for (anti)neutrino charged current quasielastic scattering on carbon, oxygen, and argon are analyzed within the relativistic distorted wave impulse approximation. One finds that these cross sections as functions of missing nucleon energy are similar to those of electron scattering and are in agreement with electron scattering data for the three nuclei. The difference between the electron and neutrino cross sections can be attributed to Coulomb distortion on the electron wave function. The averaged reduced cross sections depend slowly upon incoming lepton energy. The approach presented in this paper provides novel constraints on nuclear models of quasielastic neutrino-nucleus scattering and can be easily applied to test spectral functions and final state interactions employed in neutrino event generators.

Published by the American Physical Society
2024
Autonomous flight performance maximization for slung load carrying rotary wing mini unmanned aerial vehicle
Authors: Uzun Metin 
Published: April 2024

Purpose
This research study aims to minimize autonomous flight cost and maximize autonomous flight performance of a slung load carrying rotary wing mini unmanned aerial vehicle (i.e. UAV) by stochastically optimizing autonomous flight control system (AFCS) parameters. For minimizing autonomous flight cost and maximizing autonomous flight performance, a stochastic design approach is benefitted over certain parameters (i.e. gains of longitudinal PID controller of a hierarchical autopilot system) meanwhile lower and upper constraints exist on these design parameters.

Design/methodology/approach
A rotary wing mini UAV is produced in drone Laboratory of Iskenderun Technical University. This rotary wing UAV has three blades main rotor, fuselage, landing gear and tail rotor. It is also able to carry slung loads. AFCS variables (i.e. gains of longitudinal PID controller of hierarchical autopilot system) are stochastically optimized to minimize autonomous flight cost capturing rise time, settling time and overshoot during longitudinal flight and to maximize autonomous flight performance. Found outcomes are applied during composing rotary wing mini UAV autonomous flight simulations.

Findings
By using stochastic optimization of AFCS for rotary wing mini UAVs carrying slung loads over previously mentioned gains longitudinal PID controller when there are lower and upper constraints on these variables, a high autonomous performance having rotary wing mini UAV is obtained.

Research limitations/implications
Approval of Directorate General of Civil Aviation in Republic of Türkiye is essential for real-time rotary wing mini UAV autonomous flights.

Practical implications
Stochastic optimization of AFCS for rotary wing mini UAVs carrying slung loads is properly valuable for recovering autonomous flight performance cost of any rotary wing mini UAV.

Originality/value
Establishing a novel procedure for improving autonomous flight performance cost of a rotary wing mini UAV carrying slung loads and introducing a new process performing stochastic optimization of AFCS for rotary wing mini UAVs carrying slung loads meanwhile there exists upper and lower bounds on design variables.
Evaluation of innovation efficiency of high-tech enterprise based on DEA and Malmquist index under the background of sustainable development
Authors: Wang Liwei , Tang Tianbo 
Published: April 2024

Purpose
This paper aims to promote the higher quality development of high-tech enterprises in China. While science and technology have greatly promoted human civilization, resources have been excessively consumed and the environment has been sharply polluted. Therefore, it is particularly important for current enterprises to make use of scientific and technological innovation to maximize the benefits of mankind, minimize the loss of nature, and promote the sustainable development of our country.

Design/methodology/approach
By using DEA-Banker-Charnes-Cooper (BCC) model and DEA-Malmquist model, this paper comprehensively examines the innovation efficiency of high-tech enterprises from both static and dynamic perspectives, and conducts a provincial comparative study with the panel data of ten representative provinces from 2011 to 2020.

Findings
The research findings are as follows: the rapid number increase of high-tech enterprises in most provinces (cities) is accompanied by an ineffective input–output efficiency; the quality of high-tech enterprises needs to comprehensively examine both input–output efficiency and total factor productivity; and there is not a positive correlation between element investment and innovation performance.

Research limitations/implications
Because the DEA model used in this paper assumes that the improvement direction of invalid units is to ensure that the input ratio of various production factors remains unchanged but sometimes the proportion of scientific and technological activities personnel and the total research and development investment is not constant. In the future, the nonradial DEA model can be considered for further research. Due to historical data statistics, more provinces, cities and longer panel data are difficult to obtain. The samples studied in this paper mainly refer to the provinces and cities that ranked first in the number of national high-tech enterprises in 2020. Limited by the number of samples, DEA analysis failed to select more input and output indicators. In the future, with the accumulation of statistical data, the existing efficiency analysis will be further optimized.

Originality/value
Aiming at the misunderstanding of emphasizing quantity and neglecting quality in the cultivation of high-tech enterprises, this paper comprehensively uses DEA-BCC model and DEA Malmquist index decomposition method to make a comprehensive comparative study on the development of high-tech enterprises in ten representative provinces (cities) from two aspects of static efficiency evaluation and dynamic efficiency evaluation.
Revolutionizing performance measures and criteria for the facilities management industry in the UAE
Authors: Mawed Mahmoud 
Published: April 2024

PurposeAmidst the complicated nature of the UAE’s facilities management (FM) industry, the need to recalibrate the existing performance measurement (PM) system measures and criteria has been resonating to ensure their ability to capture the FM industry trends and dynamics, thus enhancing organizational excellence. Therefore, this research aimed to propose a specific PM tool to the country’s FM industry to accurately assess performance and establish strategic enhancements.Design/methodology/approachThe study reviewed literature on the available PM systems to gather the available measures, which were presented to a focus group of seven participants, who were purposively selected based on their expertise in FM and PM implementation in the UAE to adjust them and add ones relevant to the UAE’s FM industry.FindingsThe focus group conducted various changes, from retaining certain measures and criteria, renaming them to simplify or make them more representative of the industry, ranking them based on their importance to limit their numbers, to finally categorizing them as enablers or results. Consequently, the final proposed tool was composed of nine dimensions with 51 measures as performance enablers and three dimensions with 11 measures as performance results. Seven measures were added by the experts, who highlighted their increasing popularity in the UAE’s FM industry.Originality/valueThrough addressing the critical void in literature, this paper develops a specific PM tool aligning with the intricacy of the UAE’s FM industry, thus providing proactive contribution to the industry’s effective and sustainable growth.
David's Bridal: Customer Relationship Management in the Digital Age
Authors: Whitler Kimberly A. , Farris Paul W. , Thompson Sylvie 
Published: April 2024

This case replaces UVA-M-0837. It can be used in a variety of marketing and strategy classes to understand how (1) at a macro level, a shift in consumer and environmental factors can impact firm strategy and (2) at a micro level, an e-mail-based marketing campaign designed to address these changes can impact firm-level performance.The case puts the students in the position of CEO Robert Huth as he is preparing for a board meeting. He had taken David's Bridal from a loss in 1996 to sales of over $1 billion by 2011, but he was concerned about future growth. People were waiting longer and longer to get married and, once they decided to, were spending much less than in the past, so the industry had seen year-over-year declines since 2007. How would David's Bridal establish its brand in the minds of a new generation of brides who shopped, purchased, and decided differently than had brides in past generations?
The first modern health communication campaign in Europe: explicit and implicit strategic intents
Authors: Dahlen Øystein Pedersen 
Published: April 2024

PurposeThe main aim of this article is to broaden the notion of strategic intent in public relations. It also develops an understanding of the social value of what can be defined as the first modern health communication campaign in Europe based on strategic intents and the development of modernity.Design/methodology/approachThe study is based on both historical research and empirical material from the Norwegian tuberculosis campaign from 1889 up to 1913, when Norwegian women achieved suffrage. The campaign is analysed in the framework of modernity and social theory. The literature on lobbying and social movements is also used to develop a theoretical framework for the notion of strategic intent.FindingsThe study shows that strategic intent can be divided into two layers: (1) the implicit strategic intent is the real purpose behind the communication efforts, whereas (2) the explicit intent is found directly in the communication efforts. The explicit intent may be presented as a solution for the good of society at the right political moment, giving an organisation the possibility to mobilise for long-term social changes, in which could be the implicit intent.Originality/valueThe distinction between explicit and implicit strategic intent broadens our understanding on how to make long-term social changes as well as how social and political changes occur in modern societies. The article also gives a historical account of what is here defined as the first modern health communication campaign in Europe and its social value.