bluuebunny/crossref_metadata_2025_split huggingface dataset:
Using Electronic Register Systems in Population Censuses
Authors: Puhachova M. V. , Gladun O. M. , Vynohradova M. V. 
Published: May 2024

Using various administrative and statistical electronic registers when carrying out population or housing censuses is becoming the increasingly applicable technology for obtaining statistical and demographic information required for taking sound and timely solutions at central government, region and territorial community level. This issue has been in the increasingly stronger focus of international organizations (such as UN Population Fund, UN Economic Commission for Europe, Eurostat), statistical offices of most advanced countries and individual researchers. But the available methodological documents and publications, especially ones of national researchers, give grounds for the conclusion that this issue needs in-depth studies for the implementation in the statistical practice.
The article’s objective is to sum up international experiences in using electronic register systems for population and housing censuses in European countries, for their due accounting in Ukrainian realities.
The EU legislation is given, recommendations of international organizations on carrying out a census on register basis are analyzed, with emphasis made on the need to introduce unique identifiers for authentification of units and linking of registers.
Experiences of using register systems for census purposes are studied and summarized by investigating the cases of two European countries: Finland and Estonia. It is stressed that Estonia that started to actively use registers for public and government needs only at the beginning of this millennium is able to quickly catch up with Finland carrying out census on register basis over several decades.
Experiences of developed countries can be useful for Ukrainian statisticians when organizing next population censuses. The forthcoming census will not yet be based on register information, but if a register system is designed, a sound demographic register and a register of addresses (buildings and housings) in particular, and a methodologically grounded plan for gradual implementation of registers for obtaining necessary information about the population is elaborated, this objective will be feasible.
A Statistical Assessment of Healthy Life Expectancy in the Regions of the Republic of Belarus
Authors: Kulak A. G. 
Published: May 2024

The cumulative potential of the sustainable innovation-driven development of the regions of the Republic of Belarus is proposed to be estimated by measuring individual sub-potentials (social, demographic, environmental-economic, investment) and subsequent modeling of the aggregate characteristics for each of the regions. It is argued that the health of the population is an important component of the social sub-potential and the necessary condition for the development of all other sub-potentials. Statistical assessment of health within the framework of the system of indicators of innovation-driven sustainable development of regions is proposed to be carried out using core indicators such as life potential and healthy life expectancy of the population. The article is devoted to a study of health in the regions of Belarus on the basis of healthy life expectancy (HLE), which reflects the average number of years lived by the population, taking into account their health status (as a rule, measured on the basis of representative surveys). That is, it is life expectancy estimated with account to the quality of the years lived. It allows to estimate the loss in life expectancy due to the deteriorating health.
The article provides a statistical assessment and analysis of HLE dynamics for the population of Belarus at birth (and for specific ages) for 2005-2018. HLE in Belarusian regions are analyzed using Sallivan’s method. The healthy life expectancy of Belarusians at birth in 2018 was 68.09 years and increased by more than 10% (or 6.49 years) compared to 2005, with an increase occurred in each of the studied ages. It was revealed that although Belarusian women lived longer, they tended to give a lower life quality assessment than men (due to “poor” health). The gap between HLEs of men and women in 2018 was 6.78 years: women’s healthy life expectancy was 71.38 years, men’s – 64.60 years. At the same time, the loss in life expectancy resulting from poor health was 4.64 years for men and 7.98 years for women. Brest region and Minsk were the leaders in terms of HLE (both in 2015 and in 2018), Vitebsk and Minsk regions were among the outsiders in 2015 and Mogilev and Minsk regions – in 2018. At the next phase, the estimated indicators, together with the indicator of life potential of the regions, will be used as the basis for assessing the population’s health as part of the social sub-potential of the country regions.
“PERDA DE IDENTIDADE CULTURAL” INDÍGENA, BARBÁRIE E O ESPAÇO ESCOLAR
Authors: Moscardini Lígia 
Published: May 2024

Este ensaio objetiva refletir se o espaço escolar acarretaria perda ou não de identidade cultural indígena. Para isso, reflete os conceitos de cultura, civilização e barbárie, bem como tece considerações sobre a escola indígena e não-indígena. O texto foi dividido em quatro partes: a primeira parte visa desconstruir a imagem estereotipada e “exótica” que se tem dos povos indígenas, e no que isso acarreta no conceito de cultura, civilização, barbárie e suas relações de poder. A segunda parte do ensaio explora sobre "perda cultural", a relação entre língua e cultura, concepções modernas sobre cultura e maneiras de realmente pensar essa preservação. Na terceira parte é mencionado sobre nossa própria crise de identidade da qual passamos em um governo autoritário e a relação deste fato com a falta de conhecimento. Finalmente, a última parte trata da reversão histórica na Educação Escolar Indígena e o que podemos aprender com os povos originários para nossas próprias reflexões sobre cultura, civilização identidade e barbárie.
Pengelolaan Limbah Pertanian berbasis Pertanian Terintegrasi Peternakan Ayam Petelur di Desa Fatutasu, Kecamatan Miomaffo Barat, Kabupaten Timor Tengah Utara
Authors: Joka Umbu 
Published: May 2024

Desa Fatutasu yang terletak di Kecamatan Miomaffo Barat menyimpan potensi sumber daya yang dapat dimanfaatkan untuk pembuatan pakan ternak unggas (ayam petelur) berbasis limbah pertanian ataupun limbah dapur berupa sisa sayur-sayuran . Pemanfaatan limbah rumah tangga dan usahatani dapat membantu mencukupi kebutuhan petani-peternak terkait pakan ternak. Pengembangan usaha ayam petelur tersebut harus didukung dengan pengembangan industri pakan melalui optimalisasi pemanfaatan sumber-sumber bahan baku lokal spesifik lokasi dan berorientasi pada pola integrasi tanaman-ternak. Tujuan dari pengabdian ini adalah untuk memberikan pelatihan dan informasi kepada mitra dan masyarakat tentang pemanfaatan limbah dapur dan limbah pertanian untuk diolah menjadi pakan ternak sehingga petani mitra dapat tercukupi kebutuhan akan pakan ternak dan nilai tambah lainnya adalah masyarakat dapat menjadi produsen pakan yang bernilai jual sehingga menghasilkan keuntungan untuk masyarakat. Metode yang digunakan adalah transfer knowledge yang disajikan dalam kegiatan penyuluhan dan demo plotting. Program pengabdian kepada masyarakat ini direncanakan akan dilaksanakan dalam waktu empat bulan (terdiri dari empat tahap, yaitu tahap persiapan, transfer knowledge melalui kegiatan penyuluhan, demo plotting, dan pendampingan). Dari hasil pengamatan, anggota Kelompok Tani UNUM yang menjadi sasaran kegiatan pengabdian sangat antusias dalam proses demo serta diskusi.
Penerapan Model Pembelajaran Probing-Prompting Dalam Meningkatkan Kemampuan Kognitif Mahasiswa Berdasarkan Perbedaan Gender
Authors: Hijriani Lailin , Simarmata Justin Eduardo , Laja Yosepha Patricia Wua 
Published: May 2024

Deskriptif kuantitatif dan deskripstif kualitatif merupakan metode penelitian yang digunakan dalam penelitian ini. Subjek penelitian berjumlah 22 orang. Subjek penelitian yang berjumlah 22 orang dilibatkan pada saat proses pembelajaran untuk melihat efektivitas penerapan model pembelajaran Probing-Prompting, sedangkan untuk melihat perbedaan kemampuan kognitif subjek penelitian berdasarkan gender, dipilih 6 orang subjek dari 22 orang subjek dengan teknik purposive sampling yaitu subjek yang memenuhi kriteria yang sesuai dengan kemampuan awal matematika terdiri dari 3 mahasiswa dan 3 mahasiswi. Hasil penelitian menunjukkan bahwa penerapan model pembelajaran Probing-Prompting efektif diterapkan dalam proses pembelajaran. Hal ini didasarkan pada pencapaian hasil belajar klasikal dengan rata-rata nilai sebesar 81,77 masuk dalam kategori baik, ketika proses pembelajaran berlangsung subjek penelitian mampu merespon dengan baik setiap pertanyaan yang diajukan oleh dosen. Selanjutnya untuk melihat perbedaan kemampuan kognitif berdasarkan perbedaan gender baik mahasiswa dan mahasiswi secara berturut-turut memperoleh rata-rata nilai sebesar 86,67 dan 98 masuk dalam kategori sangat baik. Kemampuan kognitif mahasiswa sampai pada level 5 yaitu mengevaluasi (C5) sedangkan kemampuan kognitif mahasiswi sampai pada level mencipta (C6). Dengan kata lain kemampuan kognitif mahasiswi lebih baik dibandingkan dengan kemampuan kognitif mahasiswa.
Terapi Hipnotis Lima Jari Terhadap Tingkat Ansietas pada Ibu Hamil Selama Masa Pendemi
Authors: Arianti Diana , Susanti Amelia 
Published: May 2024

Berdasarkan data Worldmeter per tanggal 07 Februari 2021, kasus COVID 19 yang terjadi di seluruh dunia terkonfirmasi sebanyak 106.684.623 jiwa dengan total kematian sebanyak 2.327.249 jiwa dan sebanyak 78.383.960 jiwa dinyatakan sembuh. Sementara di Indonesia terdapat sebanyak 1.157.837 jiwa dengan total kematian 31.556 dan 949.990 yang dinyatakan sembuh (Worldmeter, 2020). Tujuan Penelitian ini untuk mengetahui pengaruh terapi hipnotis 5 jari terhadap tingkat ansietas pada ibu hamil selama masa pendemi. Jenis penelitian ini menggunakan Quasi Eksperiment dengan rancangan two group pretest-Posttest Design. Efektifitas perlakuan dinilai dengan cara membandingkan nilai post test dan pre test. Penelitian ini telah dilakukan dari bulan Maret sampai Juli 2021 di wilayah kerja Puskesmas Kuranji Kota Padang. Populasi dalam penelitian ini semua ibu hamil yang ada di wilayah kerja Puskesmas Kuranji Kota Padang dengan Sampel 30 responden ibu hamil. Hasil penelitian nilai p. value =0,0001 artinya ada pengaruh hipnotis lima jari terhadap tingkat kecemasan pada ibu hamil dimasa pendemi. Kesimpulan dari penelitian pada analisis menunjukkan bahwa antara pengaruh tingkat kecemasan dengan terapi hinoptis lima jari memiliki hubungan yang sangat signifikan sehingga hipotesis pertama dalam penelitian ini. Diharapkan penerapan terapi hipnotis 5 jari bisa dilakukan secara mandiri oleh ibu-ibu dalam mengatasi kecemasannya.
Traditional Chinese herbal formulas modulate gut microbiome and improve insomnia in patients with distinct syndrome types: insights from an interventional clinical study
Authors: Zeng Huimei , Xu Jia , Zheng Liming , Zhan Zhi , Fang Zenan , Li Yunxi , Zhao Chunyi , Xiao Rong , Zheng Zhuanfang , Li Yan , Yang Lingling 
Published: May 2024

BackgroundTraditional Chinese medicine (TCM) comprising herbal formulas has been used for millennia to treat various diseases, such as insomnia, based on distinct syndrome types. Although TCM has been proposed to be effective in insomnia through gut microbiota modulation in animal models, human studies remain limited. Therefore, this study employs machine learning and integrative network techniques to elucidate the role of the gut microbiome in the efficacies of two TCM formulas — center-supplementing and qi-boosting decoction (CSQBD) and spleen-tonifying and yin heat-clearing decoction (STYHCD) — in treating insomnia patients diagnosed with spleen qi deficiency and spleen qi deficiency with stomach heat.MethodsSixty-three insomnia patients with these two specific TCM syndromes were enrolled and treated with CSQBD or STYHCD for 4 weeks. Sleep quality was assessed using the Pittsburgh Sleep Quality Index (PSQI) and Insomnia Severity Index (ISI) every 2 weeks. In addition, variations in gut microbiota were evaluated through 16S rRNA gene sequencing. Stress and inflammatory markers were measured pre- and post-treatment.ResultsAt baseline, patients exhibiting only spleen qi deficiency showed slightly lesser severe insomnia, lower IFN-α levels, and higher cortisol levels than those with spleen qi deficiency with stomach heat. Both TCM syndromes displayed distinct gut microbiome profiles despite baseline adjustment of PSQI, ISI, and IFN-α scores. The nested stratified 10-fold cross-validated random forest classifier showed that patients with spleen qi deficiency had a higher abundance of Bifidobacterium longum than those with spleen qi deficiency with stomach heat, negatively associated with plasma IFN-α concentration. Both CSQBD and STYHCD treatments significantly improved sleep quality within 2 weeks, which lasted throughout the study. Moreover, the gut microbiome and inflammatory markers were significantly altered post-treatment. The longitudinal integrative network analysis revealed interconnections between sleep quality, gut microbes, such as Phascolarctobacterium and Ruminococcaceae, and inflammatory markers.ConclusionThis study reveals distinct microbiome profiles associated with different TCM syndrome types and underscores the link between the gut microbiome and efficacies of Chinese herbal formulas in improving insomnia. These findings deepen our understanding of the gut-brain axis in relation to insomnia and pave the way for precision treatment approaches leveraging TCM herbal remedies.
Organokines and liver enzymes in adolescent girls with polycystic ovary syndrome during randomized treatments
Authors: Garcia-Beltran Cristina , Peyrou Marion , Navarro-Gascon Artur , López-Bermejo Abel , de Zegher Francis , Villarroya Francesc , Ibáñez Lourdes 
Published: May 2024

IntroductionPolycystic ovary syndrome (PCOS) is often associated with metabolic-associated fatty liver disease (MAFLD). MAFLD has been associated with altered hepatic function, systemic dysmetabolism, and abnormal circulating levels of signaling molecules called organokines. Here, we assessed the effects of two randomized treatments on a set of organokines in adolescent girls with PCOS and without obesity, and report the associations with circulating biomarkers of liver damage, which were assessed longitudinally in the aforementioned studies as safety markers.Materials and methodsLiver enzymes [aspartate aminotransferase (AST), alanine aminotransferase (ALT), and gamma-glutamyl transferase (GGT)] were assessed as safety markers in previous randomized pilot studies comparing the effects of an oral contraceptive (OC) with those of a low-dose combination of spironolactone-pioglitazone-metformin (spiomet) for 1 year. As a post hoc endpoint, the organokines fibroblast growth factor-21 (FGF21), diazepam-binding protein-1 (DBI), and meteorin-like protein (METRNL) were assessed by ELISA after 6 months of OC (N = 26) or spiomet (N = 28). Auxological, endocrine-metabolic, body composition (using DXA), and abdominal fat partitioning (using MRI) were also evaluated. Healthy, age-matched adolescent girls (N = 17) served as controls.ResultsCirculating ALT and GGT levels increased during OC treatment and returned to baseline concentrations in the post-treatment phase; in contrast, spiomet treatment elicited no detectable changes in ALT and GGT concentrations. In relation to organokines after 6 months of treatment, (1) FGF21 levels were significantly higher in PCOS adolescents than in control girls; (2) DBI levels were lower in OC-treated girls than in controls and spiomet-treated girls; and (3) no differences were observed in METRNL concentrations between PCOS girls and controls. Serum ALT and GGT levels were directly correlated with circulating METRNL levels only in OC-treated girls (R = 0.449, P = 0.036 and R = 0.552, P = 0.004, respectively).ConclusionThe on-treatment increase in ALT and GGT levels occurring only in OC-treated girls is associated with circulating METRNL levels, suggesting enhanced METRNL synthesis as a reaction to the hepatic changes elicited by OC treatment.Clinical Trial Registrationhttps://doi.org, identifiers 10.1186/ISRCTN29234515, 10.1186/ISRCTN11062950.
Type 1 diabetes impairs the activity of rat testicular somatic and germ cells through NRF2/NLRP3 pathway-mediated oxidative stress
Authors: Venditti Massimo , Romano Maria Zelinda , Boccella Serena , Haddadi Asma , Biasi Alessandra , Maione Sabatino , Minucci Sergio 
Published: May 2024

BackgroundIt is well known that metabolic disorders, including type 1 diabetes (T1D), are often associated with reduced male fertility, mainly increasing oxidative stress and impairing the hypothalamus–pituitary–testis (HPT) axis, with consequently altered spermatogenesis and reduced sperm parameters. Herein, using a rat model of T1D obtained by treatment with streptozotocin (STZ), we analyzed several parameters of testicular activity.MethodsA total of 10 adult male Wistar rats were divided into two groups of five: control and T1D, obtained with a single intraperitoneal injection of STZ. After 3 months, the rats were anesthetized and sacrificed; one testis was stored at -80°C for biochemical analysis, and the other was fixed for histological and immunofluorescence analysis.ResultsThe data confirmed that T1D induced oxidative stress and, consequently, alterations in both testicular somatic and germ cells. This aspect was highlighted by enhanced apoptosis, altered steroidogenesis and Leydig cell maturity, and impaired spermatogenesis. In addition, the blood–testis barrier integrity was compromised, as shown by the reduced levels of structural proteins (N-cadherin, ZO-1, occludin, connexin 43, and VANGL2) and the phosphorylation status of regulative kinases (Src and FAK). Mechanistically, the dysregulation of the SIRT1/NRF2/MAPKs signaling pathways was proven, particularly the reduced nuclear translocation of NRF2, affecting its ability to induce the transcription of genes encoding for antioxidant enzymes. Finally, the stimulation of testicular inflammation and pyroptosis was also confirmed, as highlighted by the increased levels of some markers, such as NF-κB and NLRP3.ConclusionThe combined data allowed us to confirm that T1D has detrimental effects on rat testicular activity. Moreover, a better comprehension of the molecular mechanisms underlying the association between metabolic disorders and male fertility could help to identify novel targets to prevent and treat fertility disorders related to T1D.
Comparative study for the performance of pure artificial intelligence software sensor and self-organizing map assisted software sensor in predicting 5-day biochemical oxygen demand for Kauma Sewage Treatment Plant effluent in Malawi
Authors: Mng’ombe M. H. , Mtonga E. W. , Chunga B. A. , Chidya R. C. G. , Malota M. 
Published: May 2024

Introduction: Modeling plays a crucial role in understanding wastewater treatment processes, yet conventional deterministic models face challenges due to complexity and uncertainty. Artificial intelligence offers an alternative, requiring no prior system knowledge. This study tested the reliability of the Adaptive Fuzzy Inference System (ANFIS), an artificial intelligence algorithm that integrates both neural networks and fuzzy logic principles, to predict effluent Biochemical Oxygen Demand. An important indicator of organic pollution in wastewater.Materials and Methods: The ANFIS models were developed and validated with historical wastewater quality data for the Kauma Sewage Treatment Plant located in Lilongwe City, Malawi. A Self Organizing Map (SOM) was applied to extract features of the raw data to enhance the performance of ANFIS. Cost-effective, quicker, and easier-to-measure variables were selected as possible predictors while using their respective correlations with effluent. Influents’ temperature, pH, dissolved oxygen, and effluent chemical oxygen demand were among the model predictors.Results and Discussions: The comparative results demonstrated that for the same model structure, the ANFIS model achieved correlation coefficients (R) of 0.92, 0.90, and 0.81 during training, testing, and validation respectively, whereas the SOM-assisted ANFIS Model achieved R Values of 0.99, 0.87 and 0.94. Overall, despite the slight decrease in R-value during the testing stage, the SOM- assisted ANFIS model outperformed the traditional ANFIS model in terms of predictive capability. A graphic user interface was developed to improve user interaction and friendliness of the developed model. Integration of the developed model with supervisory control and data acquisition system is recommended. The study also recommends widening the application of the developed model, by retraining it with data from other wastewater treatment facilities and rivers in Malawi.
Emodin inhibits respiratory syncytial virus entry by interactions with fusion protein
Authors: Xiong Yingcai , Tan Guangxing , Tao Keyu , Zhou Yinghui , Li Jun , Ou Weiying , Shen Cunsi , Xie Tong , Zhang Chao , Hou Yayi , Ji Jianjian 
Published: May 2024

IntroductionRespiratory syncytial virus (RSV) fusion (F) protein is essential for facilitating virus entry into host cells, providing a hopeful path for combating viral diseases. However, F protein inhibitors can rapidly select for viral resistance. Thus, discovering new inhibitors of F-protein is necessary to enrich the RSV drug development pipeline.MethodsIn this study, we screen 25 bioactive compounds from Chinese herbal medicines that exhibit a strong binding to the RSV-F protein using surface plasmon resonance.ResultsAfter screening, we found emodin could strongly bind to RSV-F protein, and could effectively curb RSV infection. Further investigations certificated that emodin specifically disrupts the attachment and internalization phases of RSV infection by targeting the RSV-F protein. In vivo studies with mice infected with RSV demonstrated that emodin effectively reduces lung pathology. This therapeutic effect is attributed to emodin’s capacity to diminish pro-inflammatory cytokine production and reduce viral load in the lungs.DiscussionIn conclusion, our findings provide initial insights into the mechanism by which emodin counters RSV infection via engagement with the RSV-F protein, establishing it as a viable contender for the development of novel therapeutic agents aimed at RSV.