bluuebunny/crossref_metadata_2025_split huggingface dataset:
On Creating a Patient-centric Database from Multiple Hospital Information Systems
Authors: De La Iglesia B. , Donell S. , Rayward-Smith V. , Bettencourt-Silva J. 
Published: August 2011

SummaryBackground: The information present in Hospital Information Systems (HIS) is heterogeneous and is used primarily by health practitioners to support and improve patient care. Conducting clinical research, data analyses or knowledge discovery projects using electronic patient data in secondary care centres relies on accurate data collection, which is often an ad-hoc process poorly described in the literature.Objectives: This paper aims at facilitating and expanding on the process of retrieving and collating patient-centric data from multiple HIS for the purpose of creating a research database. The development of a process roadmap for this purpose illustrates and exposes the constraints and drawbacks of undertaking such work in secondary care centres.Methods: A data collection exercise was carried using a combined approach based on segments of well established data mining and knowledge discovery methodologies, previous work on clinical data integration and local expert consultation. A case study on prostate cancer was carried out at an English regional National Health Service (NHS) hospital.Results: The process for data retrieval described in this paper allowed patient-centric data, pertaining to the case study on prostate cancer, to be successfully collected from multiple heterogeneous hospital sources, and collated in a format suitable for further clinical research.Conclusions: The data collection exercise described in this paper exposes the lengthy and difficult journey of retrieving and collating patient-centric, multi-source data from a hospital, which is indeed a non-trivial task, and one which will greatly benefit from further attention from researchers and hospital IT management.
Uso racional de la energía eléctrica y eficiencia energética aplicado al edificio 4A en la UNAH
Authors: Rivera Dennis A , Olguín Naun R , Nieto Roger F 
Published: August 2011

Actualmente el país vive una crisis energética debido a que la producción de energía eléctrica en su mayoría es térmica, aproximadamente en un 70%. Esta situación de crisis surge, primero por los altos precios de los combustibles, ya que la generación de energía eléctrica en nuestro país depende del Bunker; segundo porque no se han implementado proyectos de generación de energía en base a recursos renovables con la suficiente capacidad y celeridad como para desplazar a la generación térmica; y tercero por el consumo excesivo de energía eléctrica. Ante estas situaciones, nos vemos obligados todos los hondureños a implementar una eficiencia energética en nuestros hogares, en la industria y en los edificios públicos y privados. La UNAH no queda exenta de esta crisis energética y se ve obligada a ejercer un plan de ahorro de energía en cada uno de sus edificios. En esta investigación presentamos alternativas viables de ahorro de energía en el sistema de iluminación del edificio 4-A, y lo más importante de este proyecto es que no ocupa una inversión monetaria, lo cual hace que sea factible casi en un 100%, y consiste en la modificación de la conexión del temporizador y una adecuada programación de los tiempos en el temporizador. Asimismo se encontró que el transformador de alimentación del edificio está sobrecargado y debe ser reemplazado en carácter de urgencia. Palabras clave: Energía eléctrica; crisis energética; consumo de energía; ahorro de energía. DOI: http://dx.doi.org/10.5377/rct.v0i5.522 Revista Ciencia y Tecnología, No. 5, Segunda época, Diciembre 2009: 107-123
Enhanced Structural Stability and Performance Durability of Bulk Heterojunction Photovoltaic Devices Incorporating Metallic Nanoparticles
Authors: Paci Barbara , Spyropoulos George D. , Generosi Amanda , Bailo Daniele , Albertini Valerio Rossi , Stratakis Emmanuel , Kymakis Emmanuel 
Published: August 2011

AbstractDespite the progress on organic photovoltaic (OPV) performance, the photoactive layer degradation during prolonged solar illumination is still a major obstacle. In this work, an approach to mitigate the degradation pathway related to structural/morphological changes of the photoactive layer occurring upon continuous illumination in air is presented. It is shown, for the first time, that the incorporation of Ag nanoparticles in poly(3‐hexylthiophene) (P3HT) and [6‐6]‐phenyl‐C61‐butyric acid methyl ester bulk heterojunction (BHJ) leads to improved structural and morphological properties of the composite BHJ solar cells and to better photovoltaic (PV) stability after long periods of continuous illumination. This is evidenced by an original approach based on joint in‐situ time‐resolved X‐ray and atomic force microscopy monitoring. Besides the structural stability improvement and reduced photodegradation rate, it is shown that the composite blends exhibit superior PV performance compared to the pristine BHJs. It can be postulated that the incorporation of metallic nanoparticles in the BHJ leads to a dual enhancement, a plasmon absorption mediated effect, causing improved initial cell efficiency, and a structural stability effect giving rise to reduced degradation rate upon prolonged illumination. The results are in favor of the exploitation of polymer–nanoparticle composites as a promising approach to mitigate the aging effects in OPVs.
Mosaic trisomy 17: Variable clinical and cytogenetic presentation
Authors: Daber Robert , Chapman Kimberly A. , Ruchelli Eduardo , Kasperski Stefanie , Mulchandani Surabhi , Thiel Brian D. , Hakonarson Hakon , Zackai Elaine H. , Conlin Laura K. , Spinner Nancy B. 
Published: August 2011

AbstractMosaic trisomy 17 is rare with only 28 cases reported and the clinical presentation is highly variable. The diagnosis is most commonly made by prenatal karyotype and in most cases is followed by a normal postnatal karyotype on blood lymphocytes. We present two cases of mosaic trisomy 17 diagnosed prenatally, with follow up in multiple tissues at birth. In the first case, trisomy 17 was identified in all amniocytes, and at birth standard results of chromosome analysis in peripheral blood were normal, but mosaic trisomy 17 was identified (50–75%) in skin fibroblasts by genome‐wide SNP array analysis. This patient presented with congenital heart disease, asymmetry, intestinal malrotation, and other anomalies and died on day 9 of life. In the second patient amniocentesis after ultrasound finding of tetralogy of Fallot showed mosaic trisomy 17. Postnatally, results of a SNP array were normal in blood, buccal mucosa, and skin. It is possible that the cardiac defect is related to trisomy 17 in key tissues during heart development, although at birth the aneuploidy could not be identified in tissues that are routinely analyzed for diagnosis. These cases add to our understanding of mosaic trisomy 17, highlighting the failure to diagnose this aneuploidy in peripheral blood. © 2011 Wiley‐Liss, Inc.
Genetic structure of Tunisian ethnic groups revealed by paternal lineages
Authors: Fadhlaoui‐Zid Karima , Martinez‐Cruz Begoña , Khodjet‐el‐khil Houssein , Mendizabal Isabel , Benammar‐Elgaaied Amel , Comas David 
Published: August 2011

AbstractTunisia has experienced a variety of human migrations that have modeled the myriad cultural groups inhabiting the area. Both Arabic and Berber‐speaking populations live in Tunisia. Berbers are commonly considered as in situ descendants of peoples who settled roughly in Palaeolithic times, and posterior demographic events such as the arrival of the Neolithic, the Arab migrations, and the expulsion of the “Moors” from Spain, had a strong cultural influence. Nonetheless, the genetic structure and the population relationships of the ethnic groups living in Tunisia have been poorly assessed. In order to gain insight into the paternal genetic landscape and population structure, more than 40 Y‐chromosome single nucleotide polymorphisms and 17 short tandem repeats were analyzed in five Tunisian ethnic groups (three Berber‐speaking isolates, one Andalusian, and one Cosmopolitan Arab). The most common lineage was the North African haplogroup E‐M81 (71%), being fixed in two Berber samples (Chenini–Douiret and Jradou), suggesting isolation and genetic drift. Differential levels of paternal gene flow from the Near East were detected in the Tunisian samples (J‐M267 lineage over 30%); however, no major sub‐Saharan African or European influence was found. This result contrasts with the high amount of sub‐Saharan and Eurasian maternal lineages previously described in Tunisia. Overall, our results reveal a certain genetic inter‐population diversity, especially among Berber groups, and sexual asymmetry, paternal lineages being mostly of autochthonous origin. In addition, Andalusians, who are supposed to be migrants from southern Spain, do not exhibit any substantial contribution of European lineages, suggesting a North African origin for this ethnic group. Am J Phys Anthropol, 2011. © 2011 Wiley‐Liss, Inc.
Preparation, cure kinetics, and thermal properties of novel acetylene terminated silazanes
Authors: Han Weijian , Ye Li , Hu Jidong , Zhao Tong 
Published: August 2011

AbstractA new kind of acetylene terminated silazanes, N‐(3‐acetylenephenyl)‐diorganosilazanes (abbreviated as APSZs) with three kind of substituents, were synthesized by the aminolysis of dichlorosilane with 3‐aminophenylacetylene (3‐APA). Structure of APSZs was confirmed by Fourier transform infrared spectroscopy (FT‐IR) and nuclear magnetic resonance (NMR). Thermal behavior of the cured silazanes was determined by thermogravimetry analysis (TGA), revealing that cured silazanes exhibited high temperature resistance. The ceramic yields of APSZ‐Me2, APSZ‐MeVi, and APSZ‐Ph2 at 1000°C under nitrogen were 77.6, 81.9, and 68.7%, respectively. The peak separation of derivative thermogravimetric data was employed to evaluate the three major regions of the thermolysis, and the kinetic parameters of thermolysis were calculated by the method of Kissinger from dynamic thermogravimetric measurement in nitrogen atmosphere at several different heating rates. Influence of substituents on the thermal behavior of cured silazanes in each separated region was discussed. The results showed that the vinyl derivative exhibit higher thermal stability than methyl and phenyl derivatives due to the high decomposition activation energy and small pendant group. © 2011 Wiley Periodicals, Inc. J Appl Polym Sci, 2012
Synthesis and characterization of poly(methyl methacrylate–butyl acrylate–acrylic acid)/polyaniline core–shell nanoparticles in miniemulsion media
Authors: Xu Xiaokuai , Shi Yuanchang , Sun Libo 
Published: August 2011

AbstractConductive polymer particles, polyaniline (PANI)‐coated poly(methyl methacrylate–butyl acrylate–acrylic acid) [P(MMA–BA–AA)] nanoparticles, were prepared. The P(MMA–BA–AA)/PANI core–shell complex particles were synthesized with a two‐step miniemulsion polymerization method with P(MMA–BA–AA) as the core and PANI as the shell. The first step was to prepare the P(MMA–BA–AA) latex particles as the core via miniemulsion polymerization and then to prepare the P(MMA–BA–AA)/PANI core–shell particles. The aniline monomer was added to the mixture of water and core nanoparticles. The aniline monomer could be attracted near the outer surface of the core particles. The polymerization of aniline was started under the action of ammonium persulfate (APS). The final product was the desired core–shell nanoparticles. The morphology of the P(MMA–BA–AA) and P(MMA–BA–AA)/PANI particles was characterized with transmission electron microscopy. The core–shell structure of the P(MMA–BA–AA)/PANI composites was further determined by Fourier transform spectroscopy and ultraviolet–visible measurements. The conductive flakes made from the core–shell latexes were prepared, and the electrical conductivities of the flakes were studied. The highest conductivity of the P(MMA–BA–AA)/PANI pellets was 2.05 S/cm. © 2011 Wiley Periodicals, Inc. J Appl Polym Sci, 2012
Thiol‐containing ionic liquid for the modification of styrene–butadiene rubber/silica composites
Authors: Lei Yanda , Tang Zhenghai , Zhu Lixin , Guo Baochun , Jia Demin 
Published: August 2011

AbstractTo introduce thiol–ene chemistry in the modification of composites by ionic liquid (IL), a novel functional IL, 1‐methylimidazolium mercaptopropionate (MimMP), was synthesized and investigated as a modifier for styrene–butadiene rubber/silica composites. MimMP could be hydrogen‐bonded with silica and react with the double bonds of rubber chains via thiol–ene chemistry. The filler networking, curing behavior, filler dispersion, crosslink density, and mechanical performance were fully studied. The filler networking in the uncured rubber compounds was effectively restrained. The vulcanization was largely accelerated by MimMP. The interfacial interaction was quantitatively evaluated and found to consistently increase with increasing MimMP. The mechanical performance and abrasion resistance of the modified vulcanizates improved considerably. The remarkable improvements were mainly ascribed to the improved interfacial structure comprised of MimMP–silica hydrogen bonding and MimMP–rubber covalent bonds via thiol–ene chemistry. © 2011 Wiley Periodicals, Inc. J Appl Polym Sci, 2011
Thermal effect of polymer layers deposition on polypropylene nonwoven fabric
Authors: Stawski D. , Połowiński S. , Herczyńska L. , Sarna E. , Rabiej S. 
Published: August 2011

AbstractTo prepare various types of multilayers, polyelectrolytes poly(acrylic acid), poly(allylamine hydrochloride), and poly(dimethyl aminoethyl methacrylate) were prepared and deposited onto polypropylene nonwoven fabrics produced in the melt‐blowing process. Each type of external layer deposited was dyed for identification. Utilizing the layer‐by‐layer method to deposit polyelectrolyte layers considerably strengthens the thermal resistance of the modified fabric (the difference in T50% is over 40°C). The effect is connected with the type and number of layers. Thermal effects were also observed in both dynamic and isothermal analyses under air atmosphere. © 2011 Wiley Periodicals, Inc. J Appl Polym Sci, 2012
Regional information science: Education and disciplinary precept in the Los Angeles Chapter of ASIST, 1961–2011
Authors: Buchanan Sarah A. 
Published: August 2011

AbstractContinuing education for information professionals serves to inform professional conduct and broaden theoretical applications. Since its establishment as a regional organization in 1961, the Los Angeles Chapter of the American Society for Information Science and Technology (LACASIS&T) has provided a program for professional development relevant across a range of information institutions within a major metropolitan area. This research examines three factors influencing continuing education activities within the Los Angeles region: founding principles, services contributed by members, and program topics drawn from the range of information professions. Methods employed comprise archival research and oral history conducted with the Chapter's founder, with attention given to the industrial context of the region. The study reveals the centrality of members' contributions to professional trends and information science applications, and a continuous history of individual leaders, contributors, and program offerings presented also emerges. The effectiveness of library and information science continuing education, when presented and coordinated by groups such as chapters, is observed in successful consortial activities consisting of both inreach and outreach to prospective program participants.
Butanol production from renewable biomass: Rediscovery of metabolic pathways and metabolic engineering
Authors: Jang Yu‐Sin , Lee Joungmin , Malaviya Alok , Seung Do Young , Cho Jung Hee , Lee Sang Yup 
Published: August 2011

AbstractBiofuel from renewable biomass is one of the answers to help solve the problems associated with limited fossil resources and climate change. Butanol has superior liquid‐fuel characteristics, with similar properties to gasoline, and thus, has the potential to be used as a substitute for gasoline. Clostridia are recognized as a good butanol producers and are employed in the industrial‐scale production of solvents. Due to the difficulty of performing genetic manipulations on clostridia, however, strain improvement has been rather slow. Furthermore, complex metabolic characteristics of acidogenesis followed by solventogenesis in this strain have hampered the development of engineered clostridia strains with highly efficient and selective butanol‐production capabilities. In recent years, the butanol‐producing characteristics in clostridia have been further characterized and alternative pathways discovered. More recently, systems‐level metabolic engineering approaches were taken to develop superior strains. Herein, we review recent discoveries of metabolic pathways for butanol production and the metabolic engineering strategies being developed.
Critical aspects of urine profiling for the selection of potential biomarkers using UPLC‐TOF‐MS
Authors: Mattarucchi Elia , Guillou Claude 
Published: August 2011

ABSTRACTBiomarker selection through the metabolomics approach involves the acquisition of nontargeted metabolic profiles. In this study, some critical factors that may affect this process were investigated using urine test samples and a UPLC‐TOF system. Repeated injections of a single sample demonstrated that the percentage of undetected and poorly repeatable measurements (intensity RSD > 15%) decreased from 22.5 to 5.8% and from 32.9 to 14.7%, respectively, as the scan time was increased up to 0.6 s (approximately 11 data points per peak). An additional critical factor was identified in the presence of broad concentration differences between the samples; the application of a dilution scheme that minimized these differences reduced the number of missing values in the final datasets by 36%. The impact of missing values was further investigated in the study of two groups of samples produced by using a spike as artificial marker. Missing values weakened the models used for the interpretation of the metabolic profiles, and greatly hindered the identification of possible markers. Finally, a simple strategy for an effective analysis of urine samples was outlined; it proved to limit the need for the post‐acquisition elaboration of the data. The same strategy can easily be adapted to other matrices. Copyright © 2011 John Wiley & Sons, Ltd.
A Highly Enantioselective Access to Chiral 1‐(β‐Arylalkyl)‐1H‐1,2,4‐triazole Derivatives as Potential Agricultural Bactericides
Authors: Lu Wen‐Chang , Cao Xiu‐Fang , Hu Ming , Li Fei , Yu Guang‐Ao , Liu Sheng‐Hua 
Published: August 2011

AbstractA series of chiral 1‐(β‐arylalkyl)‐1H‐1,2,4‐triazole derivatives has been designed as potential antifungal agents. The target triazoles have been synthesized by using a chiral auxiliary as a controlling reagent. All of the compounds were obtained with high ee values, reaching up to 99%. Preliminary bioassay results have revealed that most of the synthesized compounds display significantly higher fungicidal activities against the species Fusarium oxysporium, Rhizoctonia solani, Botrytis cinereapers, Gibberella zeae, Dothiorella gregaria, and Colletotrichum gossypii than the commercial agent triadimefon. Moreover, some of the enantiomers have been found to display significant differences in activity.
Design, Synthesis, and Evaluation of 5′‐Diphenyl Nucleoside Analogues as Inhibitors of the Plasmodium falciparum dUTPase
Authors: Hampton Shahienaz E. , Baragaña Beatriz , Schipani Alessandro , Bosch‐Navarrete Cristina , Musso‐Buendía J. Alexander , Recio Eliseo , Kaiser Marcel , Whittingham Jean L. , Roberts Shirley M. , Shevtsov Mikhail , Brannigan James A. , Kahnberg Pia , Brun Reto , Wilson Keith S. , González‐Pacanowska Dolores , Johansson Nils Gunnar , Gilbert Ian H. 
Published: August 2011

AbstractDeoxyuridine 5′‐triphosphate nucleotidohydrolase (dUTPase) is a potential drug target for malaria. We previously reported some 5′‐tritylated deoxyuridine analogues (both cyclic and acyclic) as selective inhibitors of the Plasmodium falciparum dUTPase. Modelling studies indicated that it might be possible to replace the trityl group with a diphenyl moiety, as two of the phenyl groups are buried, whereas the third is exposed to solvent. Herein we report the synthesis and evaluation of some diphenyl analogues that have lower lipophilicity and molecular weight than the trityl lead compound. Co‐crystal structures show that the diphenyl inhibitors bind in a similar manner to the corresponding trityl derivatives, with the two phenyl moieties occupying the predicted buried phenyl binding sites. The diphenyl compounds prepared show similar or slightly lower inhibition of PfdUTPase, and similar or weaker inhibition of parasite growth than the trityl compounds.
Quality of care in patients with bladder cancer
Authors: Chamie Karim , Saigal Christopher S. , Lai Julie , Hanley Jan M. , Setodji Claude M. , Konety Badrinath R. , Litwin Mark S. ,   the Urologic Diseases in America Project
Published: August 2011

AbstractBACKGROUND:Although there is level I evidence demonstrating the superiority of intravesical therapy in patients with bladder cancer, surveillance strategies are primarily founded on expert opinion. The authors examined compliance with surveillance and treatment strategies and the pursuant impact on survival in patients with high‐grade disease.METHODS:Using linked Surveillance, Epidemiology, and End Results (SEER)‐Medicare data, the authors identified subjects with a diagnosis of high‐grade, non–muscle‐invasive disease between 1992 and 2002 who survived 2 years and did not undergo definitive treatment during that time. Nonlinear mixed‐effects regression analyses was used to examine compliance with surveillance and treatment strategies. After adjusting for confounders using a propensity score‐weighted approach, the authors determined whether individual and comprehensive strategies during the initial 2 years after diagnosis were associated with survival after 2 years.RESULTS:Of 4790 subjects, only 1 received all the recommended measures. Although mean utilization for most measures significantly increased after 1997, only compliance with an induction course of bacillus Calmette‐Guerin (BCG) increased (13% to 20%; P < .001). On multivariate analysis, compliance with ≥ 4 cystoscopies, ≥ 4 cytologies, and BCG instillation was found to be lower among octogenarians and higher among those with undifferentiated, Tis, and T1 tumors, and among those individuals diagnosed after 1997. Subjects compliant with these measures had a lower hazard of mortality (hazard ratio, 0.41; 95% confidence interval, 0.18‐0.93) than those who received < 4 cystoscopies, < 4 cytologies, and no BCG.CONCLUSION:There was a statistically significant survival advantage found among those who received at least half of the recommended care. Improving compliance with these process‐of‐care measures via systematic quality improvement initiatives serves as the primary target to meliorate bladder cancer care. Cancer 2012;. © 2011 American Cancer Society.