bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of Inpatient Occupational Rehabilitation vs. Outpatient Acceptance and Commitment Therapy on Sick Leave and Cost of Lost Production: 7-Year Follow-Up of a Randomized Controlled Trial
Authors: Aasdahl Lene , Gismervik Sigmund Østgård , Johnsen Roar , Vasseljen Ottar , Bjørnelv Gudrun M. W. , Bjørngaard Johan Håkon , Fimland Marius Steiro 
Published: April 2024

Abstract
Objectives
Previously, we reported that an inpatient multimodal occupational rehabilitation program (I-MORE) was more effective than outpatient Acceptance and Commitment Therapy (O-ACT) in reducing sickness absence and was cost-effective over a 24-month period. Here we present 7-years of follow-up on sick leave and the cost of lost production.

Methods
We randomized individuals aged 18–60, sick-listed due to musculoskeletal or mental health disorders to I-MORE (n = 82) or O-ACT (n = 79). I-MORE, lasting 3.5 weeks, integrated ACT, physical training, and work-related problem-solving. In contrast, O-ACT mainly offered six weekly 2.5 h group sessions of ACT. We measured outcomes using registry data for days on medical benefits and calculated costs of lost production. Our analysis included regression analyses to examine differences in sickness absence days, logistic general estimating equations for repeated events, and generalized linear models to assess differences in costs of lost production.

Results
Unadjusted regression analyses showed 80 fewer days of sickness absence in the 7-year follow-up for I-MORE compared to O-ACT (95% CI − 264 to 104), with an adjusted difference of 114 fewer days (95% CI − 298 to 71). The difference in costs of production loss in favour of I-MORE was 27,048 euros per participant (95% CI − 35,009 to 89,104).

Conclusions
I-MORE outperformed O-ACT in reducing sickness absence and production loss costs during seven years of follow-up, but due to a limited sample size the results were unprecise. Considering the potential for substantial societal cost savings from reduced sick leave, there is a need for larger, long-term studies to evaluate return-to-work interventions.
Process Evaluation and Investigation of Cultural Adaptations for an Online Parent-Based Intervention Using a Mixed-Method Approach
Authors: Morgan Reed M. , Trejo Constanza , Trager Bradley M. , Boyle Sarah C. , Koning Ina M. , LaBrie Joseph W. 
Published: April 2024

AbstractMost alcohol intervention research focuses on program efficacy, yet few studies have investigated the acceptability of a program’s design and implementation to the target population or adapting existing alcohol interventions to different populations. To address these gaps in the literature, we (1) examined participant responsiveness to and implementation quality of FITSTART+, a web-app delivered parent-based alcohol intervention designed for incoming first-year college students in the United States, and (2) gathered feedback on how this intervention could be adapted to other populations of parents. A sample of U.S. parents of 17–20-year-old first-year college students (N = 109) participated in FITSTART+ during their child’s first year of college and completed a survey about parents’ responsiveness to the app and its quality. Next, a sample of non-U.S. parents of adolescents aged 13 to 19 (N = 44) participated in one of 11 focus groups in which they briefly explored the app and then discussed how it could be adapted to be applicable and culturally relevant for them and their context. Results revealed that U.S. parents rated the intervention’s quality as high and parents were responsive to the web-app’s content, but some did not visit one of the most critical aspects of the intervention (i.e., alcohol-related parenting resources). Non-U.S. participants provided a range of suggestions for adapting the intervention to their context, which varied by culture. Results identify areas for improvement, particularly regarding the use of alcohol-related parenting resources, in this intervention and for web-delivered PBIs more broadly.
A new method for satellite-based remote sensing analysis of plant-specific biomass yield patterns for precision farming applications
Authors: Hagn Ludwig , Schuster Johannes , Mittermayer Martin , Hülsbergen Kurt-Jürgen 
Published: April 2024

AbstractThis study describes a new method for satellite-based remote sensing analysis of plant-specific biomass yield patterns for precision farming applications. The relative biomass potential (rel. BMP) serves as an indicator for multiyear stable and homogeneous yield zones. The rel. BMP is derived from satellite data corresponding to specific growth stages and the normalized difference vegetation index (NDVI) to analyze crop-specific yield patterns. The development of this methodology is based on data from arable fields of two research farms; the validation was conducted on arable fields of commercial farms in southern Germany. Close relationships (up to r > 0.9) were found between the rel. BMP of different crop types and study years, indicating stable yield patterns in arable fields. The relative BMP showed moderate correlations (up to r = 0.64) with the yields determined by the combine harvester, strong correlations with the vegetation index red edge inflection point (REIP) (up to r = 0.88, determined by a tractor-mounted sensor system) and moderate correlations with the yield determined by biomass sampling (up to r = 0.57). The study investigated the relationship between the rel. BMP and key soil parameters. There was a consistently strong correlation between multiyear rel. BMP and soil organic carbon (SOC) and total nitrogen (TN) contents (r = 0.62 to 0.73), demonstrating that the methodology effectively reflects the impact of these key soil properties on crop yield. The approach is well suited for deriving yield zones, with extensive application potential in agriculture.
Determining the relationship of p16INK4a and additional molecular markers of aging with clinical frailty in hematologic malignancy
Authors: Rosko Ashley E. , Elsaid Mohamed I. , Woyach Jennifer , Islam Nowshin , Lepola Noah , Urrutia Jazmin , Christian Lisa M. , Presley Carolyn , Mims Alice , Burd Christin E. 
Published: April 2024

Abstract
Purpose
Older adults with hematologic malignancies (HM) have unique challenges due to age and fitness. The primary aim of this pilot study was to benchmark the ability of multiple biomarkers of aging (p16, epigenetic clocks, T cell gene expression profiles, and T cell receptor excision circles (TREC) to identify frailty as measured by a clinical impairment index (I2) in patients with HM.

Methods
70 patients newly diagnosed with HM had peripheral blood T lymphocytes (PBTL) analyzed for p16INK4a expression using the OSU_Senescence Nanostring CodeSet. PBTL epigenetic age was measured using 7 epigenetic clocks, and TREC were quantified by qRT-PCR. A composite clinical impairment index (I2) was generated by combining values from 11 geriatric metrics (Independent Activities of Daily Living (iADL), physical health score, Short Physical Performance Battery (SPPB), Body Mass Index (BMI), Eastern Cooperative Oncology Group (ECOG) performance status, self-reported KPS, Blessed Orientation Memory Concentration (BOMC), polypharmacy, Mental Health Inventory (MHI)-17, Medical Outcomes Study (MOS) subscales). Clinical frailty was defined as a score of 7 or greater on the I2.

Results
Age-adjusted p16INK4a was similar in newly diagnosed patients and healthy controls (p > 0.1). PBTL p16INK4a levels correlated positively with the Hannum [r = 0.35, 95% CI (0.09–0.75); p adj. = 0.04] and PhenoAge [r = 0.37, 95% CI (0.11–0.59); p adj. = 0.04] epigenetic clocks. The discrimination ability of the I2 model was calculated using the area under the receiver operating characteristic curve (AUC). After adjusting for chronologic age and disease group, baseline p16INK4a [AUC = 0.76, 95% CI (0.56–0.98); p = 0.01], Hannum [AUC = 0.70, 95% CI (0.54–0.85); p = 0.01], PhenoAge [AUC = 0.71, 95% CI (0.55–0.86); p = 0.01], and DunedinPACE [AUC = 0.73, 95% CI (0.57–0.88); p =  < 0.01] measures showed the greatest potential to identify clinical frailty using the I2.

Conclusions
Our pilot data suggest that multiple blood-based aging biomarkers have potential to identify frailty in older adults with HM.

Implications for Cancer Survivors
We developed the I2 index to quantify impairments across geriatric domains and discovered that PBTL p16, Hannum, PhenoAge, and DunedinPACE are promising indicators of frailty in HM.
Insight into Low-Temperature One-Step Biopreparation and Natural Dyeing of Cotton as an Environmentally Benign Route
Authors: Erdem İşmal Özlenen 
Published: April 2024

AbstractThe goal of this study is to present an environmentally benign route for cotton fabric and investigate the effect of different pretreatments in natural dyeing. In this context, conventional alkaline scouring, conventional hydrogen peroxide bleaching, low-temperature one-step biopreparation processes, namely enzymatic scouring (alkaline pectinase and alkaline pectinase-neutral cellulase combination) at 55 °C and enzyme-bleaching agent (hydrogen peroxide/sodium percarbonate/sodium perborate)-activator agent (TAED) combinations at 65 °C were applied to 100% cotton knitted fabric. The use of agricultural waste and eco-friendly mordants was preferred in natural dyeing. For this purpose, pretreated fabrics were dyed with the outer green shell of almond fruit extracts and a low amount of 0.4 g/L metal mordants (alum and iron(II) sulfate) in accordance with the simultaneous mordanting method. The dyeing properties of bio- and conventionally prepared cotton fabrics were examined in terms of colorimetric data (K/S, CIELa*b*C*h°) and wash fastness compared with water absorbency, whiteness, weight loss, pectin removal, and type of mordant. Excellent wash fastness values were achieved regardless of the type of pretreatment. Low-temperature one-step biopreparation can be a good substitute for conventional scouring and bleaching processes. Since different results can be achieved, it is essential to determine and evaluate all bioprocess conditions depending on the end-use characteristics of the textile (e.g. whether it will be white or dyed/printed, its color and lightness/darkness) at the laboratory and industrial scale applications.
Litter Decomposition in Retreating Coastal Forests
Authors: Smith Alexander J. , Valentine Kendall , Small John M. , Khan Aliya , Gedan Keryn , Nordio Giovanna , Fagherazzi Sergio , Kirwan Matthew L. 
Published: April 2024

AbstractRising sea levels lead to the migration of salt marshes into coastal forests, thereby shifting both ecosystem composition and function. In this study, we investigate leaf litter decomposition, a critical component of forest carbon cycling, across the marsh-forest boundary with a focus on the potential influence of environmental gradients (i.e., temperature, light, moisture, salinity, and oxygen) on decomposition rates. To examine litter decomposition across these potentially competing co-occurring environmental gradients, we deployed litterbags within distinct forest health communities along the marsh-forest continuum and monitored decomposition rates over 6 months. Our results revealed that while the burial depth of litter enhanced decomposition within any individual forest zone by approximately 60% (decay rate = 0.272 ± 0.029 yr−1 (surface), 0.450 ± 0.039 yr−1 (buried)), we observed limited changes in decomposition rates across the marsh-forest boundary with only slightly enhanced decomposition in mid-forest soils that are being newly impacted by saltwater intrusion and shrub encroachment. The absence of linear changes in decomposition rates indicates non-linear interactions between the observed environmental gradients that maintain a consistent net rate of decomposition across the marsh-forest boundary. However, despite similar decomposition rates across the boundary, the accumulated soil litter layer disappears because leaf litter influx decreases from the absence of mature trees. Our finding that environmental gradients counteract expected decomposition trends could inform carbon-climate model projections and may be indicative of decomposition dynamics present in other transitioning ecosystem boundaries.
Sensitivity analysis of urban air mobility aircraft design and operations including battery charging and swapping
Authors: Ratei Patrick , Naeem Nabih , Prakasha Prajwal Shiva , Nagel Björn 
Published: April 2024

AbstractUrban Air Mobility (UAM) is an evolving concept of passenger transportation providing on-demand flights within metropolitan environments, wherefore typically fully electric vertical take-off and landing aircraft are designed. Due to the underlying battery energy constraints, the design of UAM aircraft is very sensitive. Apart from the design considerations, the impact of aircraft operations on the entire UAM transport network must be examined. As there is no data from real-world operations available, this research article utilizes a system of systems simulation framework combining aircraft design with an agent-based simulation. The underlying approach offers the possibility of studying several parameters concerning UAM aircraft design and operations. In a case study focused on intra-city transport, aircraft design aspects regarding the payload capacity, the mission profile, and the reserve requirement are studied for a multirotor configuration. Furthermore, the aircraft operations aspects are focused on the turnaround procedures, the passenger demand, and the cruise speed. The multi-level sensitivity analysis ranging from the subsystem over the system of interest to the system of systems level allows us to trace the most sensitive aspects. Especially, the sensitivity analysis of battery fast-charging and swapping shows the importance of the holistic system of systems investigations for the successful development of UAM aircraft and services.
Conversion rate to open surgery during transanal total mesorectal excision (TaTME) for rectal cancer: a single-center experience
Authors: Tirelli Flavio , Lorenzon Laura , Biondi Alberto , Neri Ilaria , Santoro Gloria , Persiani Roberto 
Published: April 2024

AbstractMinimally invasive techniques for rectal cancer have demonstrated considerable advantages in terms of faster recovery and less post-operative complications. However, due to the complex anatomy and a limited surgical field, conversion to open surgery is still sometimes required, with a negative impact on the short-and long-term outcomes. The purpose of this study was to analyse the conversion rate to open abdominal surgery during laparoscopic transanal total mesorectal excision (TaTME) procedures performed at a high-volume Italian referral center. All consecutive TaTME performed for mid-to-low rectal cancer between 2015 and 2023 were reviewed, independently if treated with a primary anastomosis (with/without a diverting ostomy) or an end stoma. All procedures were performed using a standardized approach by the same surgical team. Patients with benign diagnosis that underwent different-from rectal resection procedures and cases pre-operatively scheduled for open surgery were excluded. The primary outcome of interest was the rate of conversion, defined as an un-planned intraoperative switch to open surgery using a midline laparotomy. Secondary aims included the comparison of patients who had a longer vs shorter operative time. Out of 220 patients, 210 were selected. In 187 cases, a primary anastomosis was performed, while 23 patients received a terminal colostomy (1 in the converted group; 22 in the full MIS- TaTME group, 10.6%). A surgical approach modification occurred in two cases, with a conversion rate of 0.95%. Median operative time was 281 min. Reasons for conversions included intra-operative difficulties impairing the mini-invasive procedure without intra-operative complications in one case, and difficulties in the laparoscopic control of an intraoperative bleeding due to a splenic lesion in another patient. Male sex and a higher BMI were found to be statistically significantly associated to longer operative time (respectively: p = 0.001 and p = 0.0025). In a high-volume center, a standardized TaTME is associated to a low conversion rate to open abdominal surgery.
A hybrid approach based on multipath Swin transformer and ConvMixer for white blood cells classification
Authors: Üzen Hüseyin , Fırat Hüseyin 
Published: April 2024

AbstractWhite blood cells (WBC) play an effective role in the body’s defense against parasites, viruses, and bacteria in the human body. Also, WBCs are categorized based on their morphological structures into various subgroups. The number of these WBC types in the blood of non-diseased and diseased people is different. Thus, the study of WBC classification is quite significant for medical diagnosis. Due to the widespread use of deep learning in medical image analysis in recent years, it has also been used in WBC classification. Moreover, the ConvMixer and Swin transformer models, recently introduced, have garnered significant success by attaining efficient long contextual characteristics. Based on this, a new multipath hybrid network is proposed for WBC classification by using ConvMixer and Swin transformer. This proposed model is called Swin Transformer and ConvMixer based Multipath mixer (SC-MP-Mixer). In the SC-MP-Mixer model, firstly, features with strong spatial details are extracted with the ConvMixer. Then Swin transformer effectively handle these features with self-attention mechanism. In addition, the ConvMixer and Swin transformer blocks consist of a multipath structure to obtain better patch representations in the SC-MP-Mixer. To test the performance of the SC-MP-Mixer, experiments were performed on three WBC datasets with 4 (BCCD), 8 (PBC) and 5 (Raabin) classes. The experimental studies resulted in an accuracy of 99.65% for PBC, 98.68% for Raabin, and 95.66% for BCCD. When compared with the studies in the literature and the state-of-the-art models, it was seen that the SC-MP-Mixer had more effective classification results.
Effect of long reaction distance on gas composition from organic-rich shale pyrolysis under high-temperature steam environment
Authors: Wang Lei , Zhang Rui , Wang Guoying , Zhao Jing , Yang Dong , Kang Zhiqin , Zhao Yangsheng 
Published: April 2024

AbstractWhen high-temperature steam is used as a medium to pyrolyze organic-rich shale, water steam not only acts as heat transfer but also participates in the chemical reaction of organic matter pyrolysis, thus affecting the generation law and release characteristics of gas products. In this study, based on a long-distance reaction system of organic-rich shale pyrolysis via steam injection, the effects of steam temperature and reaction distance on gas product composition are analyzed in depth and compared with other pyrolysis processes. The advantages of organic-rich shale pyrolysis via steam injection are then evaluated. The volume concentration of hydrogen in the gas product obtained via the steam injection pyrolysis of organic-rich shale is the highest, which is more than 60%. The hydrogen content increases as the reaction distance is extended; however, the rate of increase changes gradually. Increasing the reaction distance from 800 to 4000 mm increases the hydrogen content from 34.91% to 69.68% and from 63.13% to 78.61% when the steam temperature is 500 °C and 555 °C, respectively. However, the higher the heat injection temperature, the smaller the reaction distance required to form a high concentration hydrogen pyrolysis environment (hydrogen concentration > 60%). When the steam pyrolysis temperature is increased from 500 °C to 555 °C, the reaction distance required to form a high concentration of hydrogen is reduced from 3800 to 800 mm. Compared with the direct retorting process, the volume concentration of hydrogen obtained from high-temperature steam pyrolysis of organic-rich shale is 8.82 and 10.72 times that of the commonly used Fushun and Kivite furnaces, respectively. The pyrolysis of organic-rich shale via steam injection is a pyrolysis process in a hydrogen-rich environment.
Cooling Curves of Concentrated Alloys, Steelmaking Slag, and Lithium Iron Phosphate
Authors: Li Delin 
Published: April 2024

Abstract
Over the past few years, a variety of melting casting projects have been performed, in collaboration with industries and universities. Concentrated alloys and nonmetallic compounds were studied including high-Si cast iron, high-Mn steel, Al-added stainless steel, high-entropy alloy, Permalloy 80 Ni alloy, Stellite Co alloy, steelmaking slag, and lithium iron phosphate (LFP). A melt synthesis of LFP was developed. Cooling curves were measured using the thermal analysis cup method and differential thermal analysis. In addition, the phase diagrams of alloys were calculated using Thermo-Calc. This paper draws on some examples of the measured cooling curves to illustrate the thermal behaviors of melts, along with a quick review of each project.
Preliminary screening of plant essential oils from an oceanic climate zone (NW Spain) for the control of equine cyathostomins
Authors: Garduño Roberto González , Vázquez María Sol Arias , Monteiro Cristiana Cazapal , Andrade Rita Sánchez , Silva Adolfo Paz 
Published: April 2024

AbstractCyathostomins (Strongylida: Cyathostominae) are gastrointestinal nematodes (GIN) that affect equines in many parts of the world. Due to anthelmintic resistance (AR), it is necessary to search for control alternatives. The objective of the study was to carry out a screening of 26 essential oils (EOs) from plants to determine in vitro their action on cyathostomins. Essential oils were obtained by hydro-distillation from leaves, flowers, fruits, and seeds of the selected species and used against the eggs of cyathostomins by means of the tests of egg hatching and larval motility inhibition. For each EO, different concentrations were prepared (250, 125, 62.5, 31.3, 15.6, 7.8, 3.9, 2.0, 1.0, 0.5 and 0.24 mg/mL). Oxfendazole at 2.5% mixed with closantel 5% was used as positive control, and PBS served as negative control. Cyathostomin eggs were obtained from feces of infected horses and infective larvae were recovered after coproculture. The in vitro test was carried out 36 h after the challenge with the EOs. The highest production of EOs was obtained from leaves of bay, eucalyptus, mallow, and basil, as well as from seeds of black pepper, coriander, cinnamon, anise, and peel of orange and cloves, cumin, and Lawson’s cypress. The oils extracted from laurel leaves, ground cinnamon, anise, cumin, and coriander seeds had a very high effect on cyathostomins eggs up to concentrations lower than 3.9 mg/mL. Therefore, in addition to the uses against other pathogens such as fungi and bacteria, some EOs might attain great importance as an alternative control strategy in the control of nematode eggs.