bluuebunny/crossref_metadata_2025_split huggingface dataset:
ChemInform Abstract: Synthetic Studies on Pancratistatin. Construction of the Phenanthridone Ring System via a Hydrogen Bond Controlled Enamide Photocyclization.
Authors: RIGBY J. H. , GUPTA V. 
Published: September 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: The Total Synthesis of (.+‐.)‐Mossambine.
Authors: KUEHNE M. E. , WANG T. , SERAPHIN D. 
Published: September 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Alternative Approaches to the Synthesis of 2′‐O‐Me Nucleosides.
Authors: BEIGELMAN L. , KARPEISKY A. , MATULIC‐ADAMIC J. , USMAN N. 
Published: September 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis, Antitumor Activity and Crystallographic Studies of Analogues of Tiazofurin.
Authors: CAPPELLACCI L. , FRANCHETTI P. , GRIFANTINI M. , MESSINI L. , ABU SHEIKHA G. , NOCENTINI G. , MORACA R. , GOLDSTEIN B. M. 
Published: September 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Oxidative Studies on trans‐(3‐Phenyl‐2‐propenyl)phenols and 2‐Methoxy‐ 4‐(2‐propenyl)phenol and 2‐Methoxy‐4‐(1‐propenyl)phenol.
Authors: IYER M. R. , BASKARAN S. , TRIVEDI G. K. 
Published: September 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Photoinduced Molecular Transformations. Part 157. A New Stereo‐ and Regioselective Synthesis of 2,6‐Diaryl‐3,7‐dioxabicyclo(3.3.0)octane Lignans Involving a β‐Scission of Alkoxyl Radicals as the Key Step. New Total Syntheses of (.+‐.)‐Sesamin, (.+‐.)‐Eudesmin, and (.+‐. )‐Yangambin.
Authors: SUGINOME H. , ORITO K. , YORITA K. , ISHIKAWA M. , SHIMOYAMA N. , SASAKI T. 
Published: September 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Asymmetric Synthesis of (‐)‐Denticulatins A and B via Group‐Selective Aldolization of a meso Dialdehyde with a Chiral N‐Propionylsultam.
Authors: OPPOLZER W. , DE BRABANDER J. , WALTHER E. , BERNARDINELLI G. 
Published: September 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Cyclopropane‐Containing Eicosanoids of Marine Origin. Biomimetic Synthesis of Constanolactones A and B from the Alga Constantinea simplex.
Authors: WHITE J. D. , JENSEN M. S. 
Published: September 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Anticancer Agents. Part 22. Efficient Total Synthesis of the Pharmacophore (VII) of the Anticancer Antibiotic CC‐1065 by Zirconocene‐ and Palladium‐Initiated Cyclizations.
Authors: TIETZE L. F. , BUHR W. 
Published: September 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Studies Directed Toward the Total Synthesis of Polycavernoside A. Enantioselective Synthesis of the Disaccharide Component.
Authors: JOHNSTON J. N. , PAQUETTE L. A. 
Published: September 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis of a Bicyclic Model for the Marine Hepatotoxin Cylindrospermopsin.
Authors: SNIDER B. B. , HARVEY T. C. 
Published: September 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Direct Observation of Channel Structures in Zeolite Y and A with a Slow‐Scan, Charge‐Coupled‐Device Camera.
Authors: SASAKI Y. , SUZUKI T. , IKUHARA Y. , SAJI A. 
Published: September 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Isomorphous Replacement of Al by Si in the Framework of Al PO4‐5 Using (NH4)2SiF6.
Authors: HERREROS B. , KLINOWSKI J. 
Published: September 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Chiral Diamines in Asymmetric Synthesis
Authors: ALEXAKIS A. , MANGENEY P. 
Published: September 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Tandem Pericyclic Reactions (TPR) of 2‐Pyrone. A Highly Efficient Entry into Complex Polycyclic Structures
Authors: MARKO I. E. , EVANS G. R. , SERES P. , SWARBRICK T. M. , KENNARD L. , DECLERCQ J.‐P. , TINANT B. , FENEAU‐DUPONT J. 
Published: September 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Homocalixarenes and Homocalixpyridines
Authors: BRODESSER G. , VOEGTLE F. 
Published: September 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Reactions of Acids and Their Derivatives
Authors: SPILLANE W. J. 
Published: September 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Lock‐and‐Key Processes at Crystalline Interfaces: Relevance to the Spontaneous Generation of Chirality
Authors: WEISSBUCH I. , POPOVITZ‐BIRO R. , LEISEROWITZ L. , LAHAV M. 
Published: September 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Approaches to the Synthesis of Anthracyclinones and Heteroanthracyclinones: Synthesis of Benzoyl‐1,4‐benzoquinones, Their Diels‐Alder Reactions and (1,5)‐Rearrangement of Adducts
Authors: SINGH P. , PARDASANI R. T. , PRASHANT A. , POKHARNA C. P. , CHAUDHARY B. 
Published: September 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Naturally Occurring Coumarino‐Lignoids
Authors: CHATTERJEE A. , DAS P. C. , JOSHI P. C. , MANDAL S. 
Published: September 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Segmentation and tracking of cytoskeletal filaments using open active contours
Authors: Smith Matthew B. , Li Hongsheng , Shen Tian , Huang Xiaolei , Yusuf Eddy , Vavylonis Dimitrios 
Published: September 2010

AbstractWe use open active contours to quantify cytoskeletal structures imaged by fluorescence microscopy in two and three dimensions. We developed an interactive software tool for segmentation, tracking, and visualization of individual fibers. Open active contours are parametric curves that deform to minimize the sum of an external energy derived from the image and an internal bending and stretching energy. The external energy generates (i) forces that attract the contour toward the central bright line of a filament in the image, and (ii) forces that stretch the active contour toward the ends of bright ridges. Images of simulated semiflexible polymers with known bending and torsional rigidity are analyzed to validate the method. We apply our methods to quantify the conformations and dynamics of actin in two examples: actin filaments imaged by TIRF microscopy in vitro, and actin cables in fission yeast imaged by spinning disk confocal microscopy. © 2010 Wiley‐Liss, Inc.
The clinical psychological diagnostic system (KPD‐38): Sensitivity to change and validity of a self‐report instrument for outcome monitoring and quality assurance
Authors: Moessner Markus , Gallas Christine , Haug Severin , Kordy Hand 
Published: September 2010

AbstractBackground: Monitoring psychotherapeutic progress requires valid and economic measures to detect change of clinical relevance. We addressed validity and sensitivity to change of the ‘Klinisch Psychologisches Diagnosesystem 38’ (KPD‐38, Clinical Psychological Diagnosis System), an instrument for outcome monitoring and quality assurance.Methods: Data from an inpatient sample (n = 1.377) were used to investigate the concurrent validity, the sensitivity to change, and the criterion validity of the KPD‐38 in comparison to the Outcome Questionnaire (OQ‐45) and the Brief Symptom Inventory (BSI).Results: Sensitivity‐specificity analyses showed similar sensitivity and higher specificity for the KPD‐38 scales compared with the BSI and OQ total scores. Change rates on the KPD‐38 distress scale (DIS) were found to be lower than on the BSI (KPD‐38 DIS: 36.6%, GSI: 67.7%) and the OQ‐45 (KPD‐38 DIS: 44.3%, OQ tot: 57.1%) total scores. Concordance was low with the BSI ([κ = 0.24] and moderate with the OQ‐45 [κ = 0.45]).Discussion: Implications for applications in the field of outcome assessment and the challenge of further validation are discussed. The relation between sensitivity to change and criterion validity is highlighted. Copyright © 2010 John Wiley & Sons, Ltd.Key Practitioner Messages:• The KPD‐38 is a self‐report questionnaire for outcome monitoring and quality assurance, which is free of charge for research purposes.• Both OQ‐45 and BSI show higher sensitivity to change than the KPD‐38, overall concordance of change is moderate.• Aspects of validity should be considered in the evaluation of sensitivity to change.
The snake venom peptide Bj‐PRO‐7a is a M1 muscarinic acetylcholine receptor agonist
Authors: Negraes Priscilla D. , Lameu Claudiana , Hayashi Mirian A. F. , Melo Robson L. , Camargo Antônio C. M. , Ulrich Henning 
Published: September 2010

AbstractProline‐rich peptides from Bothrops jararaca venom (Bj‐PRO) were characterized based on the capability to inhibit the somatic angiotensin‐converting enzyme. The pharmacological action of these peptides resulted in the development of Captopril, one of the best examples of a target‐driven drug discovery for treatment of hypertension. However, biochemical and biological properties of Bj‐PROs were not completely elucidated yet, and many recent studies have suggested that their activity relies on angiotensin‐converting enzyme‐independent mechanisms. Here, we show that Bj‐PRO‐7a (<EDGPIPP) specifically activates [Ca2+]i transients in CHO‐M1 cells expressing heterologous rat M1 muscarinic subtype. The activation curve established by microfluorimetry in CHO‐M1 cells using increasing concentrations of Bj‐PRO‐7a reached the maximum response in the presence of 3 μM
Bj‐PRO‐7a (EC50 = 0.25 ± 0.07 μM). The variation observed by calcium imaging in these cells ranged from 52 to 1218 nM (EC50 = 0.31 ± 0.12 μM). [Ca2+]
i responses in CHO‐M1 cells were largely inhibited by pirenzepine, a specific M1 antagonist. Neural‐differentiated P19 cells expressing endogenous M1 receptors were also responsive to Bj‐PRO‐7a application, whereas no such response was observed in undifferentiated P19 cells not expressing muscarinic receptors. As further support for its specific action on M1 receptors, the peptide did not activate M3 subtypes in transfected CHO cells. Our findings provide a novel M1 muscarinic receptor agonist that could be used for basic research and even for pharmacological applications. © 2010 International Society for Advancement of Cytometry
Immunoglobulin secretion by B1 cells: Differential intensity and IRF4‐dependence of spontaneous IgM secretion by peritoneal and splenic B1 cells
Authors: Holodick Nichol E. , Tumang Joseph R. , Rothstein Thomas L. 
Published: September 2010

AbstractPeritoneal B1 cells are typified by spontaneous, constitutive secretion of IgM natural antibody, detected by ELISPOT assay, among other means. Recently, this key characteristic has been called into question, a reason for which we evaluated the integrity of IgM+ ELISPOT spots. We found that fixed B1 cells fail to produce ELISPOT spots, that interference with Golgi function inhibits ELISPOT spot formation, and that B1 cell‐derived immunoglobulin in supernatant samples is EndoH‐resistant. These findings indicate that spots produced by B1 cells on ELISPOT assay reflect secretory IgM actively exported by viable B1 cells. Current paradigms propose that interferon response factor 4 (IRF4) is required for plasma cell differentiation and immunoglobulin secretion. However, we found that IgM secretion by peritoneal B1 cells is not altered in IRF4‐null mice. In contrast, spontaneous IgM secretion by splenic B1 cells, which amounts to much more IgM secreted per cell, is dramatically reduced in the absence of IRF4. These results indicate that peritoneal B1 cells spontaneously secrete low levels of IgM via an IRF4‐independent non‐classical pathway, and, considering the low level of serum IgM in IRF‐null mice, further suggest that accumulation of serum immunoglobulin depends on IRF4‐dependent secretion by splenic B1 cells.
Modulation of systemic antigen‐specific immune responses by oral antigen in humans
Authors: Kapp Kerstin , Maul Jochen , Hostmann Arwed , Mundt Pamela , Preiss Jan C. , Wenzel Arlett , Thiel Andreas , Zeitz Martin , Ullrich Reiner , Duchmann Rainer 
Published: September 2010

AbstractOral antigen uptake can induce systemic immune responses ranging from tolerance to immunity. However, the underlying mechanisms are poorly understood, especially in humans. Here, keyhole limpet hemocyanin (KLH), a neoantigen which has been used in earlier studies of oral tolerance, was fed in a repeated low‐dose and a single high‐dose protocol to healthy volunteers. KLH‐specific CD4+ T‐cell proliferation and cytokine production, as well as KLH‐specific serum Ab and the effects of oral KLH on a subsequent parenterally induced systemic immune response, were analyzed. Repeated low‐dose oral KLH alone induced antigen‐specific CD4+ T cells positive predominantly for the gut‐homing receptor integrin β7 and the cytokines IL‐2 and TNF‐α; some CD4+ T cells also produced IL‐4. Oral feeding of KLH accelerated a subsequent parenterally induced systemic CD4+ T‐cell response. The cytokine pattern of KLH‐specific CD4+ T cells shifted toward more IL‐4‐ and IL‐10‐ and less IFN‐γ‐, IL‐2‐ and TNF‐α‐producing cells. The parenterally induced systemic KLH‐specific B‐cell response was accelerated and amplified by oral KLH. The impact of single high‐dose oral KLH on antigen‐specific immune responses was less pronounced compared with repeated low‐dose oral KLH. These findings suggest that oral antigen can effectively modulate subsequently induced systemic antigen‐specific immune responses. Immunomodulation by oral antigen may offer new therapeutic strategies for Th type1‐mediated inflammatory diseases and for the development of vaccination strategies.
Involvement of HNP‐1 in different oxidation mechanisms in human endothelial cells
Authors: Fen Du , Lingyan Ping , Chunyan He , Hong Yu , Jia Cao , Junzhu Wu 
Published: September 2010

AbstractThe objective of this study was to elucidate the different mechanisms of low‐density lipoprotein (LDL) oxidation by human endothelial cells. High level of LDL stimulated human alpha‐defensin 1 (HNP‐1) expression strongly, activated myeloperoxidase (MPO), and accumulated malondialdehyde (MDA). In addition, lipopolysaccharides (LPS) had similar effect, however the cell response occurred even earlier. After 12 h of LDL co‐culture, the cells were washed and fresh LDL was added again. MPO activity and MDA generation were increased. Adding fresh LDL after the LPS co‐culture for 3 h, a similar trend, however weaker effect was observed. Culturing cells with LDL and adding various kinds of calcium antagonists at the same time did not make obvious changes to the expression of HNP‐1. In contrast, culturing cells with LPS, calcium antagonists increased HNP‐1 expression. Adding the anti‐radical drug sodium ferulate had no significant effect on oxidative function activated by LDL, but the oxidation activated by LPS was suppressed significantly and the HNP‐1 expression was not changed significantly. The endogenous irritant LDL and the exogenous irritant LPS activated human endothelial cells in different manners and HNP‐1 expression changes were involved.
An Amphiphilic Polymer‐ and Carbon Nanotube‐Modified Indium Tin Oxide Electrode for Sensitive Electrochemical DNA Detection with Low Nonspecific Binding
Authors: Aziz Md. Abdul , Jo Kyungmin , Lee Jeong‐Ah , Akanda Md. Rajibul Haque , Sung Daekyung , Jon Sangyong , Yang Haesik 
Published: September 2010

AbstractWe herein report an amphiphilic polymer‐, carboxylated multiwalled carbon nanotube (CNT)‐, silane polymer‐, and streptavidin‐modified indium tin oxide (ITO) electrode that allows low nonspecific binding and efficient immobilization of DNA, along with good electrocatalytic activities and low background‐current levels. The low nonspecific binding results from the well‐covering of the CNT and ITO surface with the amphiphilic polymer and silane polymer, as well as the poly(ethylene glycol) groups of the polymers. The streptavidin for DNA immobilization is covalently attached to the carboxylic acid groups of the amphiphilic polymer and CNT. A low surface coverage of CNT on the ITO electrode provides the good electrocatalytic activities and low background‐current levels. The fabricated electrode enables us to achieve a detection limit of 100 pM in DNA detection.
High Sensitivity and Reproducibility of a Bismuth/Poly(bromocresol purple) Film Modified Glassy Carbon Electrode for Determination of Trace Amount of Cadmium by Differential Pulse Anodic Stripping Voltammetry
Authors: Yang Gongjun , Yan Jiankang , Qi Fen , Sun Cheng 
Published: September 2010

AbstractThis work described a novel type of bismuth/poly(bromocresol purple) film modified glassy carbon electrode (denoted as Bi/Poly(BCP)/GCE) for anodic stripping analysis of trace Cd2+. The Bi/Poly(BCP)/GCE was fabricated in situ by depositing simultaneously bismuth and cadmium by reduction at −1.20 V on the poly(BCP) film using a differential pulse voltammetry. Under the optimum conditions, the anodic stripping peak current response increased linearly with the Cd2+ concentrations in a range of 2.0×10−8–1.0×10−7 M and 1.0×10−7–6.0×10−6 M in 0.1 M NaAc‐HAc buffer solution (pH 5.0) with the detection limit of 6.5×10−9 M (S/N=3). The Bi/poly(BCP)/GCE performed good reproducibility and high sensitivity. Finally, this proposed method was successfully applied to determine the concentration of Cd2+ in water samples.
Selectivity Modification of SnO2‐Based Materials for Gas Sensor Arrays
Authors: Krivetskiy V. , Ponzoni A. , Comini E. , Badalyan S. , Rumyantseva M. , Gaskov A. 
Published: September 2010

AbstractAn enhancement of selectivity of sensor materials, based on nanocrystalline SnO2 is reported. Selectivity toward target gases such as CO, NO2, NH3, H2S and acetone vapor, could be achieved by selection of catalytic cluster distributed over the surface of thick film material. Presented results allow us to propose application of obtained materials in “electronic nose” sensor systems.