bluuebunny/crossref_metadata_2025_split huggingface dataset:
PALEOGEN DAVRI YOTQIZIQLARIDA TARQALGAN FOYDALI QAZILMA KONLARINING LITOLOGIK-FATSIAL SHAROITGA BOG‘LIQLIGI
Authors: Po‘latjon SULTONOV,  , Bahodir MELIBOYEV,  , Nilufar GAFFAROVA  
Published: June 2024

Maqolada oxirgi yillar davomida to‘plangan ko‘plab burg‘i quduqlari ma’lumotlariga asoslanib, Farg‘ona botig‘i va Toshkentoldi hududlarida tarqalgan paleogen davri yotqiziqlarining o‘ziga hos litologik, petrografik, stratigrafik va fatsial hususiyatlari hamda noruda foydali qazilmalarga istiqbolliligini o‘rganish natijalari yoritilgan.
СИНТЕЗ И ИССЛЕДОВАНИЕ КОМПЛЕКСНЫХ СОЕДИНЕНИЙ ЦИНКА, КАДМИЯ И СВИНЦА (II) С 1-(2-ПИРИДИЛАЗО)-2-НАФТОЛОМ
Authors: Гулчехра АБДУЛЛАЕВА  , Сардор МУРОДОВ  , Шахло ДАМИНОВА  
Published: June 2024

Синтезированы и исследованы комплексные соединения цинка, кадмия и свинца c 1-(2-пиридилазо)-2-нафтолом. Состав и строение полученных комплексных соединений установлены методами ICP-OES, рентгенофлуоресцентного анализа, сканирующей электронной микроскопии с энергодисперсионным анализом, ИК-спектроскопии, дифференциально-термическим анализом, а также квантовохимическими расчетными методами. Были установлены, что в комплексах M:L вступает в реакцию в соотношениях 1:2.
ASOSIDA POLIETILEN BO‘LGAN METALL TO‘LDIRUVCHILI NANOKOMPOZIT POLIMERLARNING TUZILISHINI O‘RGANISH
Authors: Xaqberdi XAMZAYEV  
Published: June 2024

Ushbu maqolada nanokompozitlarning kadmiy zarralari hajm bo‘yicha metallpolimer tarkibida deyarli teng ravishda taqsimlanishi tajribada aniqlandi.
Influence of Simulated Erosion on Soil Properties and Maize Yield in the Southern Guinea Savanah Zone of Nigeria II
Authors: B.I. Agada , P.I. Agber , S. Idoga , F.D. Ugese 
Published: June 2024

Aims: Long-term studies have been launched to assess the influence of artificial topsoil loss and its effects on soil properties and grain yield of cultivated maize.
Place and Duration of Study: The study was conducted during the 2016 to 2019 agricultural seasons at the Federal University of Agriculture in Makurdi, Nigeria.
Methodology: Three geo- referenced sites within the Federal University of Agriculture Makurdi, Nigeria namely: Site 1, Site_2 and Site_3 was used for the experiment. Erosion levels were established in June 2016 only by the incremental removal of topsoil at various depths. The study of crop productivity using simulated erosion was carried out using Randomized Complete Block Design (RCBD) with desurfaced soil depths of 0cm (control), 5cm, 10cm, 15cm and 20cm as treatments. One profile pit was also dug in each of the three sites for soil characterization and soil type establishment. Data collected on soil physical and chemical properties as well as crop growth parameters and grain yield was subjected to Analysis of Variance (ANOVA) using R core Statistical Software.
Results: The study revealed that the soils of the three sites were classified as Kandic Paleustepts for Site_1, Typic Plinthustalfs for Site_2 and Typic Hapluderts for Site_3. These has brrn reported in drtail in paper I. In comparison with the 0cm (control), maize grain yield was reduced by 7%, 89%, 100% and 100% at Site_1, 5%, 64%, 82% and 85% at Site_2 and 6%, 71%, 82% and 92% at Site_3 for the 5cm, 10cm, 15cm and 20cm topsoil depth removal respectively. The topsoil loss greatly lowered the grain yield of maize. We report the effects of topsoil loss on crop productivity for two years.
Investigating the Cardio-protective Activity of Agaricus bisporus in Wistar Rats Induced with Myocardial Infarction
Authors: Oladejo A.A. , Onwubuya E.I. , Kalu O. A. , Okeke C.B. , Okeke C.M. , Ikemefuna P.N. 
Published: June 2024

Myocardial infarction is now recognized as one of the chronic diseases and the leading cause of death across the globe. The use of plants abundant in our environment, especially Agaricus bisporusprovides a cheap alternative to combat this common foe of mankind. Hence, this study was carried out to evaluate the cardio-protective effect of the leaf extract of Agaricus bisporus in isoproterenol-induced myocardial infarction. Fresh sample of Agaricus bisporus were purchased from a market at Asaba, Delta State, Nigeria. The samples were thereafter shredded with a knife and oven-dried at 40oC and pulverized and extracted, using Solvent-solvent (ethanol and water) (7:3) via maceration for 72 hr. The filtrate was evaporated to dryness to obtain the ethanol extract which was used for further bioassay study. The animals were administered with the extract of A. bisporus orally for fourteen consecutive days at a divided dose of 100 mg/kg, 200 mg/kg and 400 mg/kg body weights and thereafter 0.2 ml isoproterenol (ISO) at 150 mg/kg was injected intraperitoneally at an interval of 24 h on the 15th and 16th day. Subsequently, the blood pressures were monitored and blood collected for bioassay studies. Assay of High density lipoprotein cholesterol (HDL-c), low density lipoprotein cholesterol (LDL-c), triglyceride (TG) and total cholesterol (TC) levels as well as activities of lactate dehydrogenase (LDH), were carried out with standard assay kit sourced from Randox laboratories Ltd, United Kingdom with maximum adherence to the manufacturer’s instruction. Results showed a significant increase (P<0.05) in high density lipoproteins (HDL) levels and lactate dehydrogenase (LDH) activities with a significant decrease (P>0.05) in low density lipoproteins (LDL) and triglyceride levels in a dose-dependent manner (100<200<400 mg/kg body weight) among the extract treated groups when compared to the untreated control group. Conversely, total cholesterol levels of extract treated groups showed no significant difference when compared with the untreated control group.The findings of this work have shown that extract of Agaricus bisporus could help to mitigate cardiovascular diseases and could be used to produce plant based products to combat myocardial infarction, thereby improving general wellbeing.
Spray Drying of Fruits Juice Formulations of Ananas cosmosus L. and Balanites aegyptiaca: Antihyperglycemic Activity
Authors: Tsatsop Roli Karole Tsague , Tchienou Gertrude Djiobie , Talla Ernest Rodrigue , Chendjou Stive Martial Sikandi , Nguimbou Richard Marcel , Ngassoum Martin Benoît 
Published: June 2024

Background: Balanites aegyptiaca is commonly used in folk medicine as antihyperglycemic agent.
Objective: Fruit juices from pineapple (Ananas cosmosus L), Balanites aegyptiaca and a blend after being encapsulated by spray dried with 10% maltodextrin, were examined for their physicochemical and antihyperglycemic properties.
Methods: Three different juice powders had been produced using spray dryer. The antihyperglycemic activity in glucose overloaded hyperglycemic rats has been evaluated.
Results: The juice powders had moisture contents ranging from 2.96 to 3.73% (dry basis). The fruit juice powders hygroscopicity varied between 14.44 and 15.38 g/100 g of juice powder samples. There were notable differences in the antihyperglycemic effects of the spray-dried juice samples on Wistar rats. Blood sugar levels were significantly (P<0.05) lower in the Wistar rats batch administered with reconstituted Balanites juice and glibenclamide at T90min compared to the Normal control batch (4.77% and 29.44% respectively). Comparing the blood sugar levels of positive control (CP), Balanites, and Pineapple + Balanites animals to those of negative control (Cneg) animals and animals given pineapple juice, a substantial (P<0.05) decrease was noted.
Conclusion: The findings indicate that encapsulation by spray drying of pineapple juice with Balanites aegyptiaca fruits can be encouraged to be processed by fruit processing industries because the resulting juice powders have good antihyperglycemic properties.
Nipping and Foliar Spray for Enhanced Seed Yield in Horsegram var. Paiyur 2
Authors: Menaka C. , Prasath S. , Yuvaraja A. , Vanitha C. , Dharan T. 
Published: June 2024

Horsegram (Macrotyloma uniflorum) is an underutilized food legume crop in the peninsular region and it belongs to the family Leguminaceae. The lower production and productivity of horsegram is due to its cultivation in rainfed areas of marginal and sub-marginal lands with poor management practices. Nutrients given as foliar spray is a unique technique to enhance plant growth by extending the availability of nutrients at all growth stages. Exogenous application of PGR enhance the crop production by altering plant stand and quality. Hence, experiments were conducted by combining foliar nutrition with nipping to improve the seed yield and quality. Nipping in the company of foliar spray of brassinolide @1 ppm registered increased plant height, branches per plant, number of pods plant-1 and seed yield plant-1 over control. The yield increases due to nipping on 40th DAS was 7% over control whereas foliar spray of brassinolide @ 1.0 ppm during flowering phase enhanced the yield upto 10% when compared to control. The plants subjected to nipping at 40 DAS combined with foliar spray of brassinolide @1.0 PPM increased the seed yield up to 11% (779 kg/ha) over control (698kg/ha).
The Anatomical School of Padua
Authors: Porzionato Andrea , Macchi Veronica , Stecco Carla , Parenti Anna , De Caro Raffaele 
Published: May 2012

AbstractThe University of Padua is one of the most ancient in the world, being founded in 1222, and the most important anatomists of the XVI, XVII, and XVIII centuries studied and taught here. Probably, the first professor of anatomy and surgery was Bruno da Longobucco (c. 1200–c. 1286), who had previously studied at the Salerno School of Medicine. While professor in Padua, Andreas Vesalius (1514–1564) published De Humani Corporis Fabrica (1543), which is considered as the birth of the modern anatomy. Following professors were Realdo Colombo (c. 1516–1559), Gabriel Fallopius (1523–1562), Hieronymus Fabricius ab Aquapendente (1533–1619), Iulius Casserius (1552–1616), Johann Wesling (1598–1649), and Johann Georg Wirsung (1589–1643). Many other foreign scholars studied in the University of Padua, such as Thomas Linacre (c. 1460–1524), the founder of the Royal College of Physicians, Werner Rolfinck (1599–1673), and Olof Rudbeck (1630–1702), who created anatomical theatres in Germany and Sweden, respectively, on the basis of the Paduan model. The anatomy of the XVII century characteristically widened the scope of its enquiry to function, as in the Exercitatio Anatomica De Motu Cordis et Sanguinis in Animalibus (1628) by William Harvey (1578–1657). Further evolution was then given by the anatomy in the XVIII century, which tried to correlate alterations of structure with clinical symptoms. The most important anatomist of this century is Giovanni Battista Morgagni (1682–1771), whose masterpiece De Sedibus et Causis Morborum per Anatomen Indagatis (1761) is a landmark contribution that is viewed as the beginning of modern pathologic anatomy. This year falls the 300th anniversary of Morgagni's inaugural lecture on medical education, Nova Institutionum Medicarum Idea (1712), which is still relevant in its effort to stress the importance of a deep knowledge of all the preclinical and clinical aspects of medical science.
Development strategies for IVIVC in an industrial environment
Authors: Cook Jack A. 
Published: May 2012

ABSTRACTProduct development is typically challenging. There is a strong desire to understand critical performance factors early in order to optimize formulations for Phase III trials or marketing approval. However, over 90% of drugs entering development in humans do not make it to the market. Thus there is a tremendous risk that resources spent early in development will be wasted as candidates attrite. To overcome this apparent dilemma, a Bayesian approach is suggested. In ‘traditional’ product development, clinical study designs are typically relatively assumption free and often do not consider learning from earlier investigations. A Bayesian approach is one in which prior information is considered when interpreting the results of the current study. A candidate IVIVC can be developed at the earliest stage of clinical development. Subsequently there are multiple opportunities within a typical development program to assess the performance of the preliminary IVIVC as new formulations are introduced. With each introduction, there is an opportunity to either confirm the adequacy of the IVIVC or to identify the need for development of a more predictive dissolution test and IVIVC. Copyright © 2012 John Wiley & Sons, Ltd.
Integrating drug permeability with dissolution profile to develop IVIVC
Authors: Takano Ryusuke , Kataoka Makoto , Yamashita Shinji 
Published: May 2012

ABSTRACTIn this review article, three different approaches to predict in vivo oral absorption based on the in vitro data of drug permeability, solubility and dissolution were introduced. At the drug discovery stage, the absorption potential of each candidate is most important to select better compounds for further development. The concept of maximum absorbable dose is applied widely, not only to evaluate the absorption potential but also to elucidate the rate‐limiting process of oral absorption that helps us to understand the cause of poor absorption. To integrate the permeability of the drug with its dissolution profile, two different approaches, in vitro dissolution/permeation system (D/P system) and in silico model and simulation method, are proposed. In the D/P system, by mimicking the in vivo process of drug absorption, the permeated amount of drugs, that is the total output of dissolution and permeation processes, are correlated with the fraction absorbed in human (Fa). This system is powerful for evaluating the improved absorption by various formulations and the effect of food intake. On the other hand, in the model and simulation approach, an intrinsic dissolution parameter of drug particle, z, was extracted from the small scale in vitro test and the process of intestinal absorption was re‐constructed in silico by incorporating the physiological parameters in human. The effective use of these approaches for the development of oral drug products is discussed through various case studies. Copyright © 2012 John Wiley & Sons, Ltd.
Coexpression of molecular chaperone enhances activity and export of organophosphorus hydrolase in Escherichia coli
Authors: Kang Dong Gyun , Kim Chang Sup , Seo Jeong Hyun , Kim Im Gyu , Choi Suk Soon , Ha Jeong Hyub , Nam Soo Wan , Lim Geunbae , Cha Hyung Joon 
Published: May 2012

AbstractPeriplasmic secretion has been used in attempts to construct an efficient whole‐cell biocatalyst with greatly reduced diffusion limitations. Previously, we developed recombinant Escherichia coli that express organophosphorus hydrolase (OPH) in the periplasmic space using the twin‐arginine translocation (Tat) pathway to degrade environmental toxic organophosphate compounds. This system has the advantage of secreting protein into the periplasm after folding in the cytoplasm. However, when OPH was expressed with a Tat signal sequence in E. coli, we found that the predominant OPH was an insoluble premature form in the cytoplasm, and thus, the whole‐cell OPH activity was significantly lower than its cell lysate activity. In this work, we, for the first time, used a molecular chaperone coexpression strategy to enhance whole‐cell OPH activity by improving the periplasmic translocation of soluble OPH. We found that the effect of GroEL‐GroES (GroEL/ES) assistance on the periplasmic localization of OPH was secretory pathway dependent. We observed a significant increase in the amount of soluble mature OPH when cytoplasmic GroEL/ES was expressed; this increase in the amount of mature OPH might be due to enhanced OPH folding in the cytoplasm. Importantly, the whole‐cell OPH activity of the chaperone–coexpressing cells was ∼5.5‐fold greater at 12 h after induction than that of cells that did not express the chaperone as a result of significant Tat‐based periplasmic translocation of OPH in the chaperone–coexpressing cells. Collectively, these data suggest that molecular chaperones significantly enhance the whole‐cell activity of periplasmic OPH‐secreting cells, yielding an effective whole‐cell biocatalyst system with highly reduced diffusion limitations. © 2012 American Institute of Chemical Engineers Biotechnol. Prog., 28: 925–930, 2012
Optimization of a Saccharomyces cerevisiae fermentation process for production of a therapeutic recombinant protein using a multivariate bayesian approach
Authors: Fu Zhibiao , Leighton Julie , Cheng Aili , Appelbaum Edward , Aon Juan C. 
Published: May 2012

AbstractVarious approaches have been applied to optimize biological product fermentation processes and define design space. In this article, we present a stepwise approach to optimize a Saccharomyces cerevisiae fermentation process through risk assessment analysis, statistical design of experiments (DoE), and multivariate Bayesian predictive approach. The critical process parameters (CPPs) were first identified through a risk assessment. The response surface for each attribute was modeled using the results from the DoE study with consideration given to interactions between CPPs. A multivariate Bayesian predictive approach was then used to identify the region of process operating conditions where all attributes met their specifications simultaneously. The model prediction was verified by twelve consistency runs where all batches achieved broth titer more than 1.53 g/L of broth and quality attributes within the expected ranges. The calculated probability was used to define the reliable operating region. To our knowledge, this is the first case study to implement the multivariate Bayesian predictive approach to the process optimization for the industrial application and its corresponding verification at two different production scales. This approach can be extended to other fermentation process optimizations and reliable operating region quantitation. © 2012 American Institute of Chemical Engineers Biotechnol. Prog., 28: 1095–1105, 2012
Enantioselective separations using chiral supported liquid crystalline membranes
Authors: Han Sangil , Rabie Feras , Marand Eva , Martin Stephen M. 
Published: May 2012

AbstractPorous and nonporous supported liquid crystalline membranes were produced by impregnating porous cellulose nitrate supports with cholesteric liquid crystal (LC) materials consisting of 4‐cyano‐4′‐pentylbiphenyl (5CB) mixed with a cholesterol‐based dopant (cholesteryl oleyl carbonate [COC], cholesteryl nonanoate [CN], or cholesteryl chloride [CC]). The membranes exhibit selectivity for R‐phenylglycine and R‐1‐phenylethanol because of increased interactions between the S enantiomers and the left‐handed cholesteric phase. The selectivity of both phenylglycine and 1‐phenylethanol in 5CB/CN membranes decreases with effective pore diameter while the permeabilities increase, as expected. Phenylglycine, which is insoluble in the LC phase, exhibits no transport in the nonporous (completely filled) membranes; however, 1‐phenylethanol, which is soluble in the LC phase, exhibits transport but negligible enantioselectivity. The enantioselectivity for 1‐phenylethanol was higher (1.20 in 5CB/COC and 5CB/CN membranes) and the permeability was lower in the cholesteric phase than in the isotropic phase. Enantioselectivity was also higher in the 5CB/COC cholesteric phase than in the nematic phase of undoped 5CB (1.03). Enantioselectivity in the cholesteric phase of 5CB doped with CC (1.1), a dopant lacking hydrogen bonding groups, was lower than in the 5CB/COC phases. Finally, enantioselectivity increases with the dopant concentration up to a plateau value at approximately 17 mol%. Chirality 24:519–525, 2012. © 2012 Wiley Periodicals, Inc.
Enantioselective Degradation of Indoxacarb in Cabbage and Soil under Field Conditions
Authors: Sun Dali , Qiu Jing , Wu Yijun , Liang Hongwu , Liu Chenglan , Li Li 
Published: May 2012

ABSTRACTThe enantioselective degradation of indoxacarb in cabbage and soil has been investigated in Beijing and Anhui under open conditions. Indoxacarb enantiomers in samples were extracted with acetonitrile, cleaned up by florisil SPE column, separated on high performance liquid chromatography with a cellulose‐tris‐(3, 5‐dimethylphenylcarbamate)‐based chiral stationary phase (CDMPC‐CSP), and determined by a photodiode array detector. The validation of the developed method by fortification rac‐indoxcarb in cabbage and soil showed good accuracy and precision. The results of field trials indicated that the dissipation of indoxacarb enantiomers followed pseudo‐first‐order kinetics or first‐order kinetics in cabbage and soil at two locations. The half‐lives of two enantiomers in cabbage ranged from 2.8 to 4.6 d which were shorter than those in soil ranging from 23 to 35 d. The changes of enantiomeric fraction values proved that enantioselective degradation of indoxacarb happened in cabbage and soil. The (−)‐indoxacarb showed faster degradation in the Beijing cabbage, whereas in the Anhui cabbage, (+)‐indoxacarb preferentially degraded. In soil, preferential degradation of (+)‐indoxacarb was observed at two locations. Chirality 24:628–633, 2012. © 2012 Wiley Periodicals, Inc.
Geomorphic response to an active transpressive regime: a case study along the Chaman strike‐slip fault, western Pakistan
Authors: Ul‐Hadi Shams , Khan Shuhab D. , Owen Lewis A. , Khan Abdul S. 
Published: May 2012

ABSTRACTThe Chaman left‐lateral strike‐slip fault bounds the rigid Indian plate boundary at the western end of the Himalayan‐Tibetan orogen and is marked by contrasting topographic relief. Deformed landforms along the fault provide an excellent record for understanding this actively evolving intra‐continental strike‐slip fault. The geomorphic response of an active transpessional stretch of the Chaman fault was studied using digital elevation model (DEM) data integrated with Advanced Spaceborne Thermal Emission and Reflection Radiometer (ASTER) Visible and Near Infrared/Short Wave Infrared (VNIR/SWIR) and images from GeoEye‐1. Geologic and geomorphic mapping helped in reconstructing the Late Quaternary landscape history of this transpessional strand of the Chaman strike‐slip fault and the associated Spinatizha thrust fault in western Pakistan. Topographic analysis of a part of the transpression (the thrust bounded Roghani ridge) revealed northward growth of the Spinatizha fault with the presence of three water gaps and two corresponding wind gaps. Geomorphic indices including stream length‐gradient index, mountain front sinuosity, valley floor width to valley height ratios, and entrenchment of recent alluvial fan deposits were used to define the lateral growth and direction of propagation of the Spinatizha fault. Left‐lateral displacement along Chaman fault and uplift along the Spinatizha fault was defined using topographic analysis of the Roghani ridge and geomorphic mapping of an impressive alluvial fan, the Bostankaul fan. The landforms and structures record slip partitioning along the Indian plate boundary, and account for the convergence resulting from the difference in the Chaman fault azimuth and orientation of the velocity vector of the Indian plate. Copyright © 2012 John Wiley & Sons, Ltd.