bluuebunny/crossref_metadata_2025_split huggingface dataset:
Persistent right umbilical vein: a prenatal condition worth mentioning?
Authors: Weichert J. , Hartge D. , Germer U. , Axt‐Fliedner R. , Gembruch U. 
Published: October 2010

AbstractObjectivesTo investigate the incidence and clinical impact of prenatally diagnosed persistent right umbilical vein (PRUV) in a referral population and to evaluate the findings together with those from previous publications.MethodsThis was a retrospective analysis of 39 cases with PRUV diagnosed in three tertiary referral centers for prenatal medicine between 1996 and 2009. Fetuses with situs inversus, situs ambiguous and heterotaxy (left and right isomerism) were excluded. During the study period 46 653 consecutive high‐ and low‐risk pregnancies were examined. The prenatal sonograms and neonatal outcome data of affected individuals were reviewed. Our findings were analyzed together with findings retrieved from the scientific literature.ResultsTwenty‐nine fetuses had an isolated PRUV as a single anomaly, whereas 10/39 (25.6%) were found to have PRUV accompanied by additional minor and major abnormalities. These anomalies comprised mainly cardiovascular, genitourinary and gastrointestinal malformations. In common with our series, previously published cases of isolated PRUV (n = 197) displayed an uneventful course of pregnancy and a favorable postnatal outcome. Sixty‐six previously reported cases of PRUV with additional anomalies were identified in the literature. Intrahepatic umbilical drainage is the most frequent type of PRUV. Including our cases, there were 16 cases (5.3%) with extrahepatic drainage of PRUV, all of which had additional anomalies.ConclusionsConsistent with previous reports, in the majority of cases (74.8%) PRUV is an isolated finding. While these cases carry an excellent prognosis, PRUV can be associated with severe congenital anomalies, so this finding should prompt detailed prenatal assessment of the fetus. Copyright © 2011 ISUOG. Published by John Wiley & Sons, Ltd.
Low‐resistance hepatic artery flow in first‐trimester fetuses: an ominous sign
Authors: Bilardo C. M. , Timmerman E. , Robles De Medina P. G. , Clur S. A. 
Published: October 2010

AbstractObjectiveLow‐resistance hepatic artery (HA) flow has been reported in severely growth‐restricted fetuses. The same finding has been incidentally observed in first‐trimester fetuses with enlarged nuchal translucency (NT). The aim of this study was to investigate HA flow in first‐trimester fetuses.MethodsCrown–rump length (CRL), NT, ductus venosus (DV) pulsatility index for veins (PIV) and HA pulsatility index (PI) were measured prospectively in fetuses at increased risk on first‐trimester assessment for aneuploidy and in a control group of low‐risk fetuses. Outcome of pregnancy was known in all cases. Independent sample t‐test was used for intergroup comparison.ResultsNT, DV‐PIV and HA‐PI were measured prospectively in 59 fetuses. Thirty‐four had an enlarged NT and underwent karyotyping, which was abnormal in 16 cases (trisomy 21, n = 12; trisomy 18, n = 3; 47,XXY, n = 1). Two pregnancies were terminated in view of fetal anomalies. In three other infants an abnormality was confirmed after birth (Noonan syndrome, unspecified genetic syndrome and cardiac defect). The remaining 13 fetuses with enlarged NT and the 25 with normal NT had an uneventful pregnancy outcome. HA‐PI was significantly and inversely correlated with NT and DV‐PIV. Mean HA‐PI was significantly lower in fetuses with adverse outcome (chromosomal anomalies 1.60; chromosomally normal fetuses with adverse outcome 1.66) than in controls (2.03).ConclusionsLow‐resistance HA flow can be observed in first‐trimester fetuses and, based on its association with adverse outcome, it can be regarded as an ominous sign. Copyright © 2011 ISUOG. Published by John Wiley & Sons, Ltd.
Ultrasound‐guided tandem placement for low‐dose‐rate brachytherapy in advanced cervical cancer minimizes risk of intraoperative uterine perforation
Authors: Watkins J. M. , Kearney P. L. , Opfermann K. J. , Ackerman S. J. , Jenrette J. M. , Kohler M. F. 
Published: October 2010

AbstractObjectivesTandem placement as part of low‐dose‐rate (LDR) brachytherapy boost for cervical cancer may be complicated by uterine perforation. The objective of this study was to describe a 10‐year experience of using intraoperative ultrasound guidance in an attempt to minimize the risk of uterine perforation.MethodsOperative and inpatient records were reviewed to identify cases in which intraoperative ultrasound guidance was employed in order to assist tandem placement, and to determine whether clinical or radiographic findings subsequently suggested uterine perforation. Demographic factors were collected in order to determine the baseline risk of perforation within this population.ResultsBetween 1998 and 2008, 71 patients underwent 110 ultrasound‐guided placements of tandem applicators. The median age was 48 (range, 26–88) years, and 20% were older than 60 years. Disease stage was FIGO IB1 (n = 10), IB2 (n = 13), IIA (n = 4), IIB (n = 19), IIIA (n = 2), IIIB (n = 16), IVA (n = 5) and IVB (n = 2). The median gravidity was 3 (range 1–10) and median parity was 3 (range 0–10). Seven patients had a preimplant history of pelvic infection, four had a history of intrauterine contraceptive device use, and 10 had a prior history of Cesarean section delivery. Only one patient experienced infection that may have been attributable to tandem placement‐associated uterine perforation. At median survivor follow‐up of 34 months, 19 patients had died. The estimated 3‐year disease‐free and overall survival rates for the entire population were 60% and 66%, respectively.ConclusionsWithin the present population, intraoperative ultrasound guidance of tandem placement was associated with no confirmed cases of uterine perforation. Copyright © 2011 ISUOG. Published by John Wiley & Sons, Ltd.
Transparente Elektroden aus Silber
Authors: Georg Andreas 
Published: October 2010

AbstractDünne Schichten aus Silber werden bereits großflächig in Wärmeschutzverglasungen eingesetzt und zeigen gute Leitfähigkeiten bei hohen Transmissionen vor allem im sichtbaren Spektralbereich. Im nahen Infraroten fällt die Transmission ab, was jedoch durch eine Ausnutzung von Interferenzen wieder ausgeglichen werden kann. Dünne Schichten aus Silber können kostengünstig hergestellt und insbesondere auch gut auf Foliensubstraten abgeschieden werden. Durch zusätzliche dielektrische Schichten lässt sich das Schichtsystem auf weitere Anforderungen anpassen, ohne die Leitfähigkeit zu beeinträchtigen. Beispiele sind die Vermeidung von Barrieren, die Anpassung der Austrittsarbeit oder die Stabilisierung gegen folgende Prozessschritte. Dadurch sind Silberelektroden für organische Leuchtdioden oder Solarzellen von besonderem Interesse.
Neural basis of visual selective attention
Authors: Chelazzi Leonardo , Della Libera Chiara , Sani Ilaria , Santandrea Elisa 
Published: October 2010

AbstractAttentional modulation along the object‐recognition pathway of the cortical visual system of primates has been shown to consist of enhanced representation of the retinal input at a specific location in space, or of objects located anywhere in the visual field which possess a critical object feature. Moreover, selective attention mechanisms allow the visual system to resolve competition among multiple objects in a crowded scene in favor of the object that is relevant for the current behavior. Finally, selective attention affects the spontaneous activity of neurons as well as their visually driven responses, and it does so not only by modulating the spiking activity of individual neurons, but also by modulating the degree of coherent firing within the critical neuronal populations. WIREs Cogni Sci 2011 2 392–407 DOI: 10.1002/wcs.117This article is categorized under:

Neuroscience > Cognition
A Prognostic Model and Treatment Strategy for Intrahepatic Recurrence of Hepatocellular Carcinoma after Curative Resection
Authors: Umeda Yuzo , Matsuda Hiroaki , Sadamori Hiroshi , Matsukawa Hiroyoshi , Yagi Takahito , Fujiwara Toshiyoshi 
Published: October 2010

AbstractBackgroundThe aim of this study was to evaluate the prognostic factors for intrahepatic recurrence of hepatocellular carcinoma (HCC) after curative resection.MethodsOf 297 patients with HCC who underwent curative resection between 1998 and 2007, 145 had intrahepatic recurrence, and 125 of these were enrolled in this study. We analyzed the relationships between overall survival after HCC recurrence and 20 variables at initial hepatectomy and recurrence.ResultsRecurrent HCC was treated by repeat hepatectomy (Re‐Hr, n = 29), radiofrequency ablation (RFA, n = 58), or transarterial chemoembolization (TAE, n = 38). Complete tumor control (CTC) by Re–He and RFA was selected for 70% of patients. RFA‐treated patients had more tumors, smaller tumors, and poorer liver function at recurrence than the Re‐Hr group. The overall 1‐, 3‐, and 5‐year post‐recurrence survival rates (SR) were 93.1, 66.8, 58.1%; 94.7, 75.1, 48.3%; and 80.1, 22.5, 0%, respectively, in the Re‐Hr, RFA, and TAE groups. The SR was better for Re‐Hr and RFA than for TAE (p < 0.0001). Outcomes were similar in Re‐Hr and RFA, regardless of recurrent tumor size. Multivariate analysis identified Child‐Pugh grade B, AFP ≥100 ng/ml at recurrence, recurrent tumor size ≥3 cm, tumor number ≥3, and CTC as significant prognostic factors for overall post‐recurrence survival. A scoring system using 1 point for each patient‐background factor provided a well‐categorized predictive model. The overall 3‐/5‐year post‐recurrence SRs were 83.1/59.3%, 64.1/41.9%, 42.0/18.0%, and 13.6/0% at risk number (R) R0, R1, R2, and R3/4, respectively (p < 0.05).ConclusionsSignificant prognostic factors for intrahepatic recurrent HCC are poor hepatic reserve, AFP, recurrent tumor size and number, and CTC. Selection of treatment modality for intrahepatic recurrence requires the clinician to be mindful of the predictive factors and to control tumors aggressively by adequate treatment, selected by balancing various conditions.
Brief report: Activities in heterosexual romantic relationships: Grade differences and associations with relationship satisfaction
Authors: Carlson Wendy , Rose Amanda J. 
Published: October 2010

ABSTRACTWhereas much research addresses relations of youths’ heterosexual romantic relationships with sexual and/or delinquent activities, less attention has been paid to youths’ more normative, day‐to‐day activities with romantic partners. This gap in the literature is problematic given that these activities define the substance of the relationships and likely are connected to relationship satisfaction. In the current study, 223 youths in fifth (28 boys; 32 girls), eighth (31 boys; 40 girls), and eleventh (36 boys; 56 girls) grades reporting current romantic relationships indicated their engagement in activities with romantic partners and relationship satisfaction. Findings revealed important grade differences in activity involvement, with eighth‐ and eleventh‐graders reporting higher engagement than fifth‐graders, especially in out‐of‐school activities. Additionally, engagement in out‐of‐school activities was most strongly associated with relationship satisfaction for all grades.
An Approach to Consistent Patient Education
Authors: Ortoleva Catherine 
Published: October 2010

AbstractPatient education is instrumental to postoperative recovery. To that end, the nurse must be able to decipher the discharge instructions and the patient and caregivers must be able to understand them. Ambulatory surgery patients are in the clinical setting for shorter periods; therefore, nurses need to provide these patients with effective educational tools that will assist them in achieving optimal surgical outcomes. In an effort to improve our perioperative and discharge orders, which were being handwritten, I created standardized forms that require little handwriting and allow surgeons to complete their orders by checkmarking the items. Use of these forms has improved turnover time, provided nurses and patients with orders that are easier to read and understand, and produced fewer incidences in which information is left off orders or misunderstood. Following up with patients to ensure their comprehension and active participation in their postsurgical care allows the nurses to assess the success of surgical care and patient satisfaction.
Surgical Resection of Atrial Myxomas
Authors: Hill Marites , Cherry Cecile , Maloney Martin , Midyette Paula 
Published: October 2010

AbstractMyxomas are the most common form of benign cardiac tumors; these tumors occur primarily in the atria. Most myxomas are idiopathic in origin, but in rare cases, patients have a family history of myxomas. Although these tumors are benign, myxomas have the potential to cause serious complications, including embolic events and partial or complete obstruction of intracardiac blood flow. Currently, there is no effective medical treatment, and surgical excision of the tumor is necessary. Typically, surgical resection of an atrial myxoma is performed via a median sternotomy with the patient on cardiopulmonary bypass. Recurrence of a myxoma after surgical excision is extremely rare, and most patients have an excellent prognosis after surgery.
Clinical Issues—October 2010
Authors: Chard Robin 
Published: October 2010

This MonthAdvance preparation of IV fluids and IV fluid hang timeKey words: IV fluid preparation, medication administration, aseptic technique.Medication reconciliation across the continuum of careKey words: National Patient Safety Goals, medication reconciliation.Preventing pressure ulcer development in surgical patientsKey words: perioperative pressure ulcers, pressure ulcer assessment tool, ulcer risk assessment tool.
Spinal cord plasticity and acid‐sensing ion channels involvement in a rodent model of irritable bowel syndrome
Authors: Matriconl Julien , Gelotl Agathe , Etiennel Monique , Lazdunskil Michel , Mullerl Emilie , Ardidl Denis 
Published: October 2010

AbstractIrritable bowel syndrome (IBS) is a common functional gastro‐intestinal disorder characterized by intractable chronic abdominal pain. In this study, we examined the possible spinal mechanisms underlying colonic hypersensitivity (CHS) using a non‐inflammatory rat model of IBS induced by rectal enemas of butyrate, a short‐chain fatty acid. We hypothesized that spinal plasticity could be responsible for CHS and that ASIC channels, which are known to support pain‐elicited currents in the spinal cord, could contribute to central sensitization in our model of IBS. First, in order to determine if visceral pain relies on changes in spinal activity, we analyzed Fos expression in the spinal cord of rats treated with butyrate following a challenge with repetitive noxious colorectal distension. We found that Fos immunoreactivity was increased in thoracic T10–11–12, lumbar L1–2–6 and sacral S1 spinal segments. In control rats treated with saline, noxious repetitive colorectal distensions evoked Fos expression only in L1–2–6 and S1 spinal segments. Secondly, intrathecal injection of PcTx1, a specific ASIC1A antagonist, in the lumbar spinal cord completely prevented the development of CHS induced by butyrate. ASIC1 and 2 mRNAs, especially ASIC1A, were upregulated in the lumbar spinal cord. ASIC1A could thus contribute to spinal sensitization in our model of IBS, as it is supported by spinal colocalization of ASIC1A and Fos proteins. The whole data pinpoint a potential critical role of thoracic spinal cord in non‐inflammatory pain states such as IBS and suggest that ASIC channels are part of the molecular effectors of central sensitization leading to visceral pain.
Regional analgesia in Italy: A survey of current practice
Authors: Allegri Massimo , Niebel Thekla , Bugada Dario , Coluzzi Flaminia , Baciarello Marco , Berti Marco , Tinelli Carmine , Borghi Battista , Grossi Paolo ,   RICALOR Group Investigators
Published: October 2010

AbstractTwo decades of attention have focused on regional anesthesia, both central neuraxial blockades as well as peripheral blocks. Though there are a considerable number of recent publications on the topic, the complex issues around the effect of regional anesthesia on outcome have not been completely resolved, possibly because the data are often not procedure‐specific.In this survey, we tried to focus on current Italian practice and therapeutical criteria in the management of postoperative pain. We also evaluated how the clinical practice of the respondents follows the international and national guidelines for postoperative pain.A questionnaire was mailed to 64 anesthesiologists who had been identified from a database kept by the RICALOR Group (Registro Italiano Complicanze Anestesia LOcoRegionale — Italian Registry of Complications during Locoregional Anesthesia). The survey requested information regarding demographic data and general management, postoperative pain management and guidelines, and specific questions on epidural analgesia and on peripheral blocks.Only 35 of the 64 anesthesiologists answered the questionnaire and sended it back for analysis. Basing on these 35 returns, data from 51 surgical units (some respondent referred data of more surgical units) leading to 135 departments (surgical units may be constituted by more departments) were analyzed. A total of 245,382 surgical procedures were analyzed. Regional analgesia was used in 46.71% of the procedures.In university and teaching‐hospitals, protocols concerning regional anesthesia were attended and shared with the whole staff more often than in non‐teaching hospitals (P = 0.0001).For postoperative pain management 31.48% of responders used <10% of regional analgesia, 20.37% used 10–30%, 25.93% used 30–50%, 14.81% used 50–75% and 7.41% used >75% of regional analgesia.We identified a huge variety of responses regarding therapeutical protocols but the majority of responders used the drugs with the best safety/efficacy profile.In conclusion, we demonstrated an improvement in the management of postoperative pain compared to previous studies, but still efforts should be made to standardize daily practice in order to avoid complications and improve safety.
Epidural space and chronic pain
Authors: Raffaeli William , Righetti Donatella , Andruccioli Jessica , Sarti Donatella 
Published: October 2010

AbstractEpidural fibrosis, flogosis, hyperemia and stasis, are some of the pathological morphologies that can be found in the epidural space (ES) of patients affected from failed back surgery syndrome (FBSS), stenosis and other chronic painful pathologies, usually grouped in the class of low back pain (LBP) syndrome. As a consequence of lumbar spine surgery fibrotic tissue commonly replace epidural fat, and large amounts of scar tissue are found around nerve roots. The diagnostic tools currently available, magnetic resonance imaging (MRI) and computer tomography (CT) are dramatically poor, and allow only the definition of pathological structural contents. The only method for monitoring the dura anatomy is during the epiduroscopy, which has been revalued only recently for the diagnosis and the treatment of FBSS. In 2001 we introduced a new endoscopic technique (the Raffaeli method) for the lysis of adhesions under direct imaging, and the study of normal and pathological morphologies of the dura.
Factors affecting the pharmacokinetics and neural block characteristics after epidural administration of local anaesthetics
Authors: Simon Mischa J.G. , Veering Bernadette T. 
Published: October 2010

AbstractEpidural anaesthesia has been shown to have a good clinical efficacy, but is hampered by a wide variability in the pharmacokinetics and neural block characteristics, resulting in a poor controllability of the spread of anaesthesia. The extent of the epidural neural blockade depends on the processes that occur during the transfer of local anaesthetics from the site of injection to the site of action. These processes include the longitudinal spread and the local tissue distribution. The longitudinal spread may be affected by anatomical and physiologic alterations, associated with increased age and local tissue distribution is influenced by the physicochemical and chiral properties of local anaesthetics. Determination of the absorption kinetics after epidural administration of local anaesthetics is important because it determines the relationship between neural blockade and the amount of drug remaining at or near the site of injection and the risk of systemic toxicity. Factors, such as age and enantiomer‐specific disposition and elimination may contribute to the differences between local anaesthetics and individual patients. Pharmacokinetic—pharmacodynamic (PK/PD)‐models for neuraxial blockade have been developed for epidural and subarachnoid administration of local anaesthetics. These models are able to explain a part of the variability by introducing covariates in the model. Furthermore, these models are able to make predictions about important clinical endpoints. Although these models still have to be validated for different clinical situations, the models may help to predict anaesthetic requirements for individual patients or new drug development in future.
Para‐aortic lymphadenectomy for primary fallopian tube cancer
Authors: Koo Yu‐Jin , Kwon Yong‐Soon , Lim Kyung‐Taek , Lee Ki‐Heon , Shim Jae‐Uk , Mok Jung‐Eun 
Published: October 2010

AbstractObjectiveTo investigate the topography of lymph node spread and the need for para‐aortic lymphadenectomy in primary fallopian tube cancer (PFTC).MethodsTwenty‐six women were diagnosed with PFTC at Cheil General Hospital and Women's Healthcare Center, Seoul, Korea, between March 1992 and November 2009. Of the 26 patients, we retrospectively analyzed 15 patients who underwent complete staging surgery, including bilateral pelvic and para‐aortic lymphadenectomy.ResultsThe median follow‐up period was 57.9 months (range, 3–185 months) and the 5‐year survival rate was 86.3%. Five (33.3%) patients were diagnosed with FIGO stage I, 1 (6.7%) with stage II, and 9 (60%) with stage III cancer. The median number of lymph nodes removed was 53.8 (range, 18–106 nodes). Four (26.7%) patients had nodal involvement: 2 patients with para‐aortic lymph node involvement and 2 patients with both pelvic and para‐aortic lymph node involvement. None of the patients was positive for pelvic lymph nodes alone.ConclusionA comprehensive para‐aortic lymphadenectomy was necessary for accurate staging in PFTC.
Spatial categorization and time perception: Why does it take less time to get home?
Authors: Raghubir Priya , Morwitz Vicki G. , Chakravarti Amitav 
Published: October 2010

AbstractThis paper identifies a new bias in consumers' time perceptions — consumers perceive a journey from a destination to home to be faster than a trip from home to the same destination. In three experiments we demonstrate that this effect occurs both for short trips and for long trips to and from home. We also show that this effect occurs for other familiar locations in addition to home. We discuss several possible causes for this effect and offer preliminary support for one possible reason that involves differences in how consumers spatially encode “home” vs. a destination. Since home is extremely familiar it enjoys a rich mental representation, and therefore, consumers may encode it as a relatively larger geographical area than the less familiar destination. We offer preliminary evidence that this can lead to a directional asymmetry in their feelings of trip progress.