bluuebunny/crossref_metadata_2025_split huggingface dataset:
Relationship between heat shock protein 70 and B amyloids in patients with alzheimer disease and vascular dementia
Authors: Fu Y. , Xiao S. 
Published: May 2011

AimsExplore the relationship between levels of plasma Aβ1–40, Aβ1–42 and heat shock protein 70 (HSP70) in patients with Alzheimer disease (AD) and vascular dementia (VD) and in elderly non-demented controls.Methods23 patients with AD and 21 patients with VD who meet diagnostic criteria of the Diagnostic Statistical Manual 4th edition and 20 control subjects were enrolled, administered the Mini-Mental State Exam (MMSE) and the Activity of Daily Living (ADL) inventory and their levels of plasma Aβ1–40, Aβ1–42 and HSP70 were measured by sandwich enzyme-linked immunosorbent assay.ResultsThe levels of plasma Aβ1–40, Aβ1–42 and the Aβ1–40/Aβ1–42 ratio were not significantly different across groups, but levels of plasma HSP70 in VD patients was significantly higher than in AD patients and in normal controls (3.19 vs 1.91 vs 1.43ng/ml, respectively; F=6.464, P=0.003). In the AD group MMSE scores were inversely correlated with ADL scores (r=-0.617, P=0.002) and with levels of plasma HSP70 (r=-0.437, P=0.037); but HSP70 levels were positively correlated with age (r=0.616, P=0.002) and with plasma Aβ1–40 (r=0.497, P=0.016) in AD group. In the VD group levels of plasma HSP70 were positively correlated with plasma Aβ1–40 (r=0.436, P=0.048).ConclusionsOur findings provide further evidence that high plasma HSP70 levels may play a role in the diagnosis and differential diagnosis of AD. HSP70 levels in AD patients is inversely associated with cognitive performance and positively correlated with plasma Aβ1–40. Plasma HSP70 in VD patients is significantly elevated and positively correlated with plasma Aβ1–40.
The evolution of memory disorder in the ederly people: do you recover, will remain stationary or dementia?
Authors: Zarra J. , Schmidt L. 
Published: May 2011

IntroductionEven though most than a hundred years have passed since we know Alzheimer's disease today it's considered as the human's frightful flagellum. While most of mental disease seem to be losing its evilness, the neurocognitives disorders caused by Alzheimer's disease, far from attenuating has duplicated it's appearance every each five years. And its symptoms are still being more depriving.So, in opposition to the rest of the illness that affect the nervous system and the psychic apparatus, which due to the new treatment has been attenuated the clinical forms’ Alzheimer. With its severe pronostic and the illness evolution, haven’t been soften.ObjectivesOur intention is firstly, share some concepts to consider Alzheimer's disease as a cruel illness that can reache all the elderly people around the world.Secondly, to analyze the different forms of presentation than can mask a clinical state. Which many times could end-up in dementia. And will soon destroy the whole psychic apparatus of a person.MethodsPresent our study group in the three institutional medical centers, with ambulatory patients, who consult about a cognitive disease. We describe the evolution trough time, taking into account the pharmacological treatments.ResultsThe importance of the early detection of memory disorder, as one of the first signs of alarm which give us the opportunity to intervene therapeutically in on time.ConclusionsWe can recognize the Mild Cognitive Disorder as a clue which reveal a first therapeutic instance probably in efficacy in this cruel evolution towards dementia.
Survey of knowledge, attitude and behavior of homosexual seminar's audiences
Authors: Andri A. 
Published: May 2011

ObjectiveTo know about knowledge, act and behavior of homosexual seminar audience about homosexual behavior.MethodThis was a cross sectional survey. Participants were chosen by purposive sampling method. Survey was conducted using list of questionnaires which was made according to references used in the seminar presentation.ResultOne hundred and sixty five participants conducted the survey. There were 77 males (46.7%) and 88 females (53.3%). The mean of age of the participants was 21.22 (SD 3.7). Most of the participants were college students (147 students, 89.1%) and never married before (96.4%). Sixty six participants (40%) said that homosexual behavior was induced by environmental situation, fifty eight participants (35.2%) said that it was a biological factor and rest of them did not answer the question. One hundred and four (63%) participants said that homosexual behavior could be cured, twenty four of participants (16.4%) said it could not be cured and the rest of them said did not have any idea. More than half of participants (87 participants, 52.7%) said that homosexual behavior was a mental disorder and most of the participants (87 participants, 79.4%) said that homosexual behavior need to be cured. Most of the participants said that they felt fine if they meet and talked with homosexual man or woman, nineteen participants felt afraid, ten participants felt disgust and twenty five participants felt pity on them.ConclusionMost of the participants considered homosexual behavior as mental disorder and need to be cured.
Chronic medical conditions mediate the association between depression and cardiovascular disease mortality
Authors: Atlantis E. , Shi Z. , Penninx B. , Wittert G. , Taylor A. , Almeida O. 
Published: May 2011

PurposeTo determine whether chronic medical conditions mediate the association between depression and cardiovascular disease (CVD) mortality.MethodsData analyzed were from 6,394 subjects aged 25–74 years who participated in extensive health examinations in the NHEFS conducted between 1971 and 1975 and follow-up studies to 1992. CVD mortality was the endpoint. Depression predictors were clinically significant depressive symptoms at baseline by the GWB-D, and/or at 1982–84 by the CES-D (‘baseline’, ‘new’, or ‘twice’ depression). Chronic conditions were prevalent/incident high blood pressure, diabetes, and nonfatal CVD by examination and/or self-report. Mediation effects were assessed by stepwise adjustments of covariates and additive interactions in competing-risks regression models (accounting for other mortality causes) and logit models.ResultsBaseline, new, and twice depression were significant predictors of CVD mortality in competing-risks models adjusted for demographics (HRs 1.3, 1.4, and 2.0), but effects were progressively weakened and became non-significant after adjustment for lifestyle factors, prevalent and incident medical conditions, respectively. CVD mortality risk was 80% higher for depression plus incident nonfatal CVD than without (HR 4.0 vs. 3.2, additive interaction), and mediation effects of depression via chronic medical conditions (particularly via incident nonfatal CVD) increased the risk by 2 to 11% in logit models, independent of all covariates.ConclusionsSeveral levels of evidence suggest that the association between depression and CVD mortality is partially mediated by prevalent/incident chronic medical conditions, as well as unhealthy lifestyle behaviors. Patients presenting with clinically significant depressive symptoms, particularly if persistent, should be assessed for both chronic conditions and lifestyle risk factors.
Leading cause of re-hospitalization in an Italian acute psychiatric unit: preliminary results
Authors: Attili T. , Atti A.R. , Moretti F. , Pedrini E. , Forlani M. , Bernabei V. , Bonafede R. , De Ronchi D. 
Published: May 2011

ObjectivesTo describe the leading cause of re-hospitalization in an Acute Psychiatric Unit of a general hospital in Bologna, Northern Italy.MethodsAll repeated admissions (>3consecutive admissions in 18 months) were recorded thanks to the Hospital Informatic System. Case-history were reviewed to collect information, diagnoses were based on the ICD-10.ResultsIn the indexed period, 392 admissions were registered for 152 patients (mean age 44; 46,1% women). At least one precipitating cause was present in 64% of admissions. The most frequent were psycho-social stress such as family conflicts, parental separations, relational problems, job or economic difficulties (39%). The co-occurrence of 2+ of such factors was common (20%). Tricky situation within the psychiatric rehabilitation service (20%), low compliance to treatments (7%), alcohol/drugs abuse (7%), and low insight (3%) were the remaining associated factors. All the re-admissions of patients with poor insight or reduced compliance were due to the same cause. Poor adherence to therapies was more frequent in bipolar disorder compared with other diagnosis (17%vs7%, p<0.005). In patients affected by personality disorders the contemporary presence of 2 or more factors was needed in 40% of admissions. Patients with schizophrenia showed the most hetherogeneous pattern of precipitating factors.ConclusionsRegardless of diagnoses, in almost a half of the admissions a single psycho-social stress is sufficient to lead to re-hospitalization; in personality disorders the contemporary presence of 2+ stressors is needed to overcome the capacity compensation of the patient. Low insight is frequently associated to re-admissions. Tailored treatments might reduce the frequency of re-hospitalization.
Anxiety and depression in hospitalized patients in Department of Oncology University Clinical Hospital Mostar
Authors: Babić D. , Perić I. , Mikulić M. 
Published: May 2011

BackgroundIn recent decades, growing interest in the research association of somatic and psychiatric disorders. Contemporary research and clinical practice shows that approximately half of cancer patients are associated with mental disorders, mostly depression and anxiety disorder.AimTo establish presence of depression and anxiety in patients hospitalized on oncology in University Clinic Hospital in Mostar.Examinees and methods: In total, 80 patients hospitalized on oncology in University Clinic Hospital in Mostar between January 1st and March 31st 2010. (Examine group) and 80 patients who were admitted in ordination of family medicine in Mostar between March 1st and March 20th 2010. (Control group), participated in the research. In research we used Becks Anxiety and Depression Inventory.ResultsExaminees hospitalized on oncology had higher presence of depression in comparison to control group (Fisher exact test, χ2 test = 23,852: P < 0,001). We found no significant difference in presence of anxiety between examine and control group (χ2 test = 3,890; P = 0,143).ConclusionControl group showed statistically higher presence of depression, while we didn’t prove statistically significant difference in presence of anxiety between examine and control group.
Is psychological distress, depression and generalised anxiety associated with gastrointestinal symptoms in Type 2 Diabetes Mellitus?
Authors: Bener A. 
Published: May 2011

AimAiming to explore whether gastrointestinal (GI) symptoms are related to psychological distress, depression and generalized anxiety in Type 2 Diabetes Mellitus (T2DM) patients.DesignCase-control study.SettingPrimary Health Care (PHC), Qatar.SubjectsThe study was based on matched by age, gender and ethnicity of 453 cases and 453 controls aged 20 years and above.MethodsThe study was based on a face to face interview with designed diagnostic screening questionnaires for GI symptoms and T2DM, Patient Health Questionnaire (PHQ-9) for depression and General Anxiety Disorders (GAD-7) for anxiety.ResultsAmong the total 453 diabetic and 453 control subjects interviewed, the prevalence of GI symptoms in T2DM was 48% and in control 34.2% (p < 0.001). Obesity and overweight were higher in patients with GI symptoms in T2DM (47.1%) compared to controls (42.7%) (p < 0.001). Mental health severity was significantly higher in patients with GI symptoms when compared to controls; depression (8.2 ± 3.7 vs 6.0 ± 3.6) and anxiety (7.6 ± 3.3 vs 6.0 ± 3.7). The prevalence of severe levels of depression was nearly twofold (8.2%) in patients with GI symptoms in T2DM vs compared to controls (2.4%) (p < 0.001). Similarly, the prevalence of severe levels of anxiety was 19.6% with GI symptoms in T2DM patients compared to controls (13.7%) (p < 0.001).ConclusionThe present study findings revealed that the prevalence rate of gastrointestinal disorders is high in T2DM. Also, GI symptoms are associated significantly with depression and generalized anxiety in T2DM patients. Anxiety was more common than depression with GI disorder in T2DM patients.
Scientometric study of scientific production in psyciatry
Authors: Biglu S. , Biglu M.H. , Falk C. 
Published: May 2011

Psychiatry is a branch of medicine that deals with the treatment of various kind of mental disorder such as diagnosis, treatment, prevention of mental and emotional disorders. In the contemporary world we witness a lot of casualties that lead to the human mental disorder but there are very little evidences to show the trend of psychiatry researches in the world.The objective of this study is to depict the scientific production of scientists in the field of psychiatry for a period of 10 years. The database of Web of Science (WoS) was used to extract all publication under the topic of psychiatry throughout 2000 – 2009.The study showed that the USA with producing more than 38% of world profiles in the field is the most prolific country followed by England (10.72%) and Germany (10.67%). English is the dominant language of publications. The majority of publications (68%) are in the form of journal articles. Harvard University with sharing 3.37% of world publications in the field is the most active university followed by Columbia University (2.20%) and Yale University (2.07%) respectively. Based on the Bradford law the Journal of Psychiatric Services is the most productive one among core Journals in the field.
Reorganization based on patient focused care programs, in the context of mental health services reform: Effects on patients
Authors: Bonin J.-P. , Lavoie-Tremblay M. , Lesage A. , Miquelon P. , Briand C. 
Published: May 2011

BackgroundWHO (2001) suggested that the population should get easier and faster access to services improvements in the management of mental disorders in primary health care. In this context, the Government of Quebec (Canada) published in 2005 a Mental Health Action Plan, based on an organization into a hierarchy and some hospitals began to reorganize their mental health services into patient focused care programs.Aims of the studyThe presentation will focus on the effects on outpatients (N = 290) who were receiving mental health services from two hospitals in Montreal.MethodsAs part of a broader study on mental health services and patient outcomes, mental health services’ patients from a psychiatric hospital and a general university hospital in Montreal, were recruited to complete the Basis24, Euroqol, SF12 and other scales. A standard recruitment protocol was followed. All incoming patients at the outpatient clinics/programs during a typical week were considered eligible. This procedure was done before the reorganization of services, in 2006 (T1), and after the reorganization of services (T2; 2 years later), in 2008. We used T-test to assess the difference of a six-month evolution between the two-time measures.ResultsRespectively, 1057 (T1) and 557 (T2) participated to the project. Generally patients showed no significative differences between the two times in their symptoms, functioning and QOL. Only some marginal aspects changes in one site or another.ConclusionPatients were not very disturbed by changes and the new program were not fully implemented two years after T1.
Interaction between personality, family, and neighborhood factors in substance use initiation among adolescents
Authors: Burdzovic Andreas J. , Watson M.W. 
Published: May 2011

AimsThis project investigated longitudinal predictors of smoking, drinking and marijuana use initiation among adolescents.MethodA community-representative sample of 440 mother-child dyads with equal gender, SES, and ethnic representation was assessed 4 times covering the span of more than 6 years.Children's reports of age of first smoke, drink and marijuana use were collected as part of the Youth Risk Behavior Survey (YRBS) at T3.Child-level predictors at T1 included child gender, race, and sensation seeking personality. Family-level predictors at T1 included maternal education, family income, and children's self-reports about exposure to home violence. Information regarding presence of drugs and gangs in schools/neighborhoods were collected from mothers and children at T1 and combined into a single measure.To examine the timing of events - specifically, the time when children started smoking, drinking and using marijuana as a function of the above T1 predictors - three separate survival models were estimated using the Cox proportional hazards model.ResultsControlling for all other predictors, the sensation-seeking temperament and neighborhood quality remained significant predictors of substance use initiation among adolescents across all three substances, such that children initiated these behaviors sooner if they were high sensation-seekers or came form dysfunctional neighborhoods. Significant person X environment interactions were also evident for smoking and marijuana use, such that neighborhood and family risks were especially potent risks among children with high sensation seeking temperaments. These results point to the importance of broader contextual influences on the negative outcomes such as substance use during adolescence.
Frequent users of an acute psychiatric inpatient unit: A 5-year retospective study
Authors: Cardoso G. , Graça J. , Klut C. , Xavier S. , Neto A. , Martins M. , Ramos J. , Ribeiro J. , Vieira C. 
Published: May 2011

IntroductionA small subset of patients with above average admissions to psychiatric inpatient units is recognized in clinical practice. These frequent users tend to be younger and to have a diagnosis of schizophrenia or affective disorder. Social conditions and the severity of the illness seem to be associated with this increased number of admissions.Aims/ObjectivesTo study demographic and clinical characteristics of frequent and non-frequent users of a psychiatric inpatient unit.MethodsRetrospective data of all the patients admitted to a psychiatric inpatient unit from January 2004 to December 2008 were reviewed. Frequent-users were defined as patients with 3 or more admissions over that period of time, and non-frequent users as those with less than 3 admissions. The two groups were compared in terms of age, gender, ethnicity, psychiatric diagnosis and compulsory admissionsResultsIn a total of 2018 admissions and 1348 patients, the frequent-user group represented 10.2% (n = 137) of the patients and 28.9%(n = 584) of the admissions. Frequent-users were significantly younger (39.5 vs. 44.5 years, p = .001), more frequently black (22.6 vs. 19.4%, p < .001) and compulsorily admitted (27.7 vs. 14%, p < .001) than non-frequent users. Patients with bipolar disorder (p = .001), schizophrenia (p = .003) belonged significantly more to frequent-users group, while unipolar depressive patients (p = .016) and other diagnosis (p = .011) was more significantly represented in the non-frequent users group. Frequency of admission did not differ with gender.ConclusionsThe results concerning age and psychiatric diagnosis are consistent with previous studies. Compulsory admissions and black ethnicity were significantly higher among frequent- users.
Systematization of collection of relevant information about community maintenance treatment of people egress of psychiatric hospitalization
Authors: Cardoso L. 
Published: May 2011

In therapeutic advances context of mental care patients, community services are essential to maintenance treatment of people with severe mental disorders especially in people egress of psychiatric hospitalization cases. This research aim was to evaluate use of instruments to collect relevant information about maintenance treatment in a community mental health service.A two years quantitative and cross-sectional study developed in a community mental health service in Ribeirao Preto city- Sao Paulo - Brazil. The sample was egress patients and their family caregivers. It was utilizing a monthly nursing interview with following during six months with each patient and caregiver, to apply: sociodemographic and clinical questions; Structured Clinical Interview for Brief Psychiatric rating Scale (SIG-BPRS); Brief Psychiatric rating Scale (SIG-BPRS); Morisky-Green Adhesion Test; Family Burden Rating Scale (brazilian version - FIBS-BR).In this satudy participated 40 patients and 15 family caregivers. Between patients majority was women and diagnosis most prevalent was Schizophrenia and mood disorders. The psychiatric symptoms manifestation presents low degrees and medication adhesion treatment was low in 78% of patients. Family care givers was women in 96% of sample and 80% presents medium to high degrees of burden.The instruments utilized was important to evidence how patients and their caregivers was in maintenance of community treatment and collaborate to mental health professionals assistance systematization. The use of validated instruments can offer important information to mental health care in community services and maintenance treatments.
Saving and empowering young lives in Europe (SEYLE). Preliminary results
Authors: Carli V. , Sarchiapone M. , Wasserman D. ,   The SEYLE Research Consortium
Published: May 2011

There have been only a few reports illustrating the effectiveness of mental health promotion and interventions to reduce risk behaviours, including suicidal behavior. The aim of the SEYLE project, which is funded by the European Union under the Seventh Framework Health Program, is to address these issues by collecting baseline and follow-up data on health and well-being among European adolescents and compiling an epidemiological database; testing, in a randomized controlled trial, three different suicide-preventive interventions; evaluating the outcome of each intervention in comparison with a control group from a multidisciplinary perspective; as well as recommending culturally adjusted models for promoting mental health and preventing suicidal behaviors. The study comprises 11,000 adolescents recruited from randomized schools in 11 European countries: Austria, Estonia, France, Germany, Hungary, Ireland, Israel, Italy, Romania, Slovenia and Spain, with Sweden serving as the scientific coordinating center. Each country performs three active interventions and one minimal intervention as a control group. The active interventions include gatekeeper training (QPR), awareness training on mental health promotion for adolescents, and screening for at-risk adolescents by health professionals. Structured questionnaires are utilized at baseline, 3- and 12-month follow-ups in order to assess changes. During this presentation the data from the baseline evaluation of SEYLE will be described.Trial registrationThe German Clinical Trials Register, DRKS00000214.