bluuebunny/crossref_metadata_2025_split huggingface dataset:
Corticosteroid Use in Patients with Glioblastoma at First or Second Relapse Treated with Bevacizumab in the BRAIN Study
Authors: Vredenburgh James J. , Cloughesy Timothy , Samant Meghna , Prados Michael , Wen Patrick Y. , Mikkelsen Tom , Schiff David , Abrey Lauren E. , Yung W.K. Alfred , Paleologos Nina , Nicholas Martin K. , Jensen Randy , Das Asha , Friedman Henry S. 
Published: December 2010

Abstract

Background.
Vascular endothelial growth factor inhibitors have corticosteroid-sparing effects in patients with high-grade gliomas. We assessed corticosteroid use in patients with recurrent glioblastoma treated with bevacizumab (BEV) in the BRAIN study (J Clin Oncol 2009;27:4733–4740).

Methods.
BRAIN was a phase II, multicenter, randomized, noncomparative trial of BEV alone (n = 85) or in combination with irinotecan (CPT-11) (n = 82) in adults with recurrent glioblastoma. Median corticosteroid dose for patients who used corticosteroids at baseline was summarized by treatment arm; the percentage of patients who had sustained (≥50% corticosteroid dose reduction for ≥50% of time on study drug) or complete (discontinuation of corticosteroid for ≥25% of time on study drug) reduction in corticosteroid dose overall and by objective response and progression-free survival was calculated. The incidence of corticosteroid-related adverse events was summarized.

Results.
In each treatment group, 50% of patients were using systemic corticosteroids at baseline. The majority of those experienced a reduction in dose while receiving BEV-based therapy. Thirteen (30.2%) BEV and 20 (46.5%) BEV + CPT-11 patients had a sustained reduction of corticosteroid dose; 7 (16.3%) BEV and 9 (20.9%) BEV + CPT-11 patients had a complete reduction of corticosteroid dose. The majority of patients who had an objective response or progression-free survival &gt;6 months experienced corticosteroid dose reduction. Approximately 64% of patients who used corticosteroids while receiving BEV-based therapy experienced infection.

Conclusion.
BEV may have corticosteroid-sparing effects in patients with recurrent glioblastoma. Corticosteroid reduction may positively affect patient health-related quality of life. Given the exploratory nature of the analyses in a noncomparative study, these results should be interpreted cautiously.
Inhibitors of mTOR
Authors: Klümpen Heinz-Josef , Beijnen Jos H. , Gurney Howard , Schellens Jan H.M. 
Published: December 2010

AbstractInhibitors of mammalian target of rapamycin (mTOR) have been approved for the treatment of renal cell carcinoma and appear to have a role in the treatment of other malignancies. The primary objective of this drug review is to provide pharmacokinetic and dynamic properties of the commonly used drugs everolimus and temsirolimus. Additionally, information on clinical use, mechanism of action, bioanalysis, drug–drug interactions, alterations with disease or age, pharmacogenetics, and drug resistance is given. This overview should assist the treating medical oncologist in adjusting treatment with mTOR inhibitors to individual patient circumstances.
Short-time measurements of interception in mountain spruce forest
Authors: Holko Ladislav 
Published: December 2010

Short-time measurements of interception in mountain spruce forestOpen area rainfall and throughfall measurements in the Western Tatra Mountains (altitude about 1500 m a.s.l.) made by tipping bucket gauges were used to estimate the usefulness of the short-time data in analysis of spruce interception. The 10-minute data from period 13 May-13 October 2009 did not reveal meaningful correlations between the open area rainfall and throughfall. Aggregated measurements representing individual rainfall events were more useful. They showed linear relationship between open area rainfall and throughfall for events with total rainfall depth in the open area exceeding 5 mm. Correlation between open area rainfall and throughfall for rainfall events with duration above 120 minutes was significantly better than for the shorter ones. Mean values of interception (percentage of open area rainfall which did not appear in throughfall) of individual rainfall events was high. When we excluded events for which throughfall was higher than the open area rainfall, mean interception for larger and longer rainfall events was 46% and 48%, respectively. For smaller (runoff depth below 5 mm) and shorter events (duration below 2 hours) the mean interception was 70% and 72%, respectively. However, the data revealed very high variability of interception.
Assessing the retention capacity of a floodplain using a 2D numerical model
Authors: Valentová Jana , Valenta Petr , Weyskrabová Lenka 
Published: December 2010

Assessing the retention capacity of a floodplain using a 2D numerical modelThis paper presents a method for assessing the retention capacity of a floodplain in the course of flooding and for estimating the significance of its water storage for transforming a flood wave. The method is based on two-dimensional numerical modeling of the flood flow in a river channel and in the adjacent floodplains, and is suitable for cases when the morphology of the flooding area is variable and complex, e.g. broad inundation areas with meandering channels. The approach adopted here enables us to quantify the retention capacity for inundation areas of various characters and with various land uses, and provides a tool for estimating the efficiency of possible measures for increasing the water storage capacity of a floodplain. The retention capacity is estimated using an evaluation of a series of detailed flood flow modeling results; the flood wave transformation effect is predicted with the aim of creating a non-linear reservoir model. A parametric study of the floodplain retention capacity for the upper branch of the Lužnice River is presented here, and the results for the current state and for various hypothetical scenarios of changes in geometry and land use are evaluated and compared.
Estimating Flow Characteristics of Different Weir Types and Optimum Dimensions of Downstream Receiving Pool
Authors: Emiroglu M. 
Published: December 2010

Estimating Flow Characteristics of Different Weir Types and Optimum Dimensions of Downstream Receiving PoolThis paper presents the results of a laboratory study on the flow characteristics of sharp-crested weirs, broad-crested weirs, and labyrinth weirs. The variation of the maximum bubble penetration depth for different weir types is investigated depending on overfall jet expansion, discharge, and drop height. Moreover, most efficient depth, length and width of the downstream receiving pool in an open channel system are studied by considering the penetration depth, overfall jet expansion, jet trajectory and the bubble zone. The results show that overfall jet expansion at the labyrinth weirs is significantly wider than the rectangular sharp-crested weirs and the trapezoidal sharp-crested weir. It is demonstrated that the labyrinth weirs have the lowest values of bubble penetration depth among the weirs tested. Furthermore, it is found that the rectangular and the trapezoidal weirs are observed to have the highest bubble penetration depth among all weirs. Consequently, empirical equations are obtained for predicting the maximum penetration depth of bubbles, trajectory of free overfall nappe, jet expansion of free overfall nappe, and the length of the bubble zone.
Comparison of the monitored and modeled soil water storage of the upper soil layer: the influence of soil properties and groundwater table level
Authors: Šútor Július , Štekauerová Vlasta , Nagy Viliam 
Published: December 2010

Comparison of the monitored and modeled soil water storage of the upper soil layer: the influence of soil properties and groundwater table levelIn the study ofTomlain(1997) a soil water balance model was applied to evaluate the climate change impacts on the soil water storage in the Hurbanovo locality (Southwestern Slovakia), using the climate change scenarios of Slovakia for the years 2010, 2030, and 2075 by the global circulation models CCCM, GISS and GFD3. These calculations did not take into consideration neither the various soil properties, nor the groundwater table influence on soil water content. In this study, their calculated data were compared with those monitored at the same sites. There were found significant differences between resulting soil water storage of the upper 100 cm soil layer, most probably due to cappilary rise from groundwater at sites 2 and 3. It was shown, that the soil properties and groundwater table depth are importat features strongly influencing soil water content of the upper soil layer; thus the application of the soil water balance equation (Eq. (1)), neglecting the above mentioned factors, could lead to the results far from reality.
The spherical harmonic representation of the gravitational field quantities generated by the ice density contrast
Authors: Tenzer Robert , Abdalla Ahmed , Vajda Peter ,   Hamayun
Published: December 2010

The spherical harmonic representation of the gravitational field quantities generated by the ice density contrastWe derive the expressions for computing the ice density contrast stripping corrections to the topography corrected gravity field quantities by means of the spherical harmonics. The expressions in the spectral representation utilize two types of the spherical functions, namely the spherical height functions and the newly introduced lower-bound ice functions. The spherical height functions describe the global geometry of the upper topographic bound. The spherical lower-bound ice functions combined with the spherical height functions describe the global thickness of the continental ice sheet. The newly derived formulas are utilized in the forward modelling of the gravitational field quantities generated by the ice density contrast. The 30×30 arc-sec global elevation data from GTOPO30 are used to generate the global elevation model (GEM) coefficients. The spatially averaged global elevation data from GTOPO30 and the 2×2 arc-deg ice-thickness data from the CRUST 2.0 global crustal model are used to generate the global lower-bound ice model (GIM) coefficients. The mean value of the ice density contrast 1753 kg/m3(i.e., difference of the reference constant density of the continental upper crust 2670 kg/m3and the density of glacial ice 917 kg/m3) is adopted. The numerical examples are given for the gravitational potential and attraction generated by the ice density contrast computed globally with a low-degree spectral resolution complete to degree and order 90 of the GEM and GIM coefficients.
Soft bottom macrofauna of an All Taxa Biodiversity Site: Hornsund (77○N, Svalbard)
Authors: Kędra Monika , Gromisz Sławomira , Jaskuła Radomir , Legeżyńska Joanna , Maciejewska Barbara , Malec Edyta , Opanowski Artur , Ostrowska Karolina , Włodarska-Kowalczuk Maria , Węsławski Jan 
Published: December 2010

Soft bottom macrofauna of an All Taxa Biodiversity Site: Hornsund (77○N, Svalbard)Hornsund, an Arctic fjord in the west coast of Spitsbergen (Svalbard), was selected as All Taxa Biodiversity Inventory (ATBI) site under EU 5th Framework Concerted Action BIOMARE (2000-2002), especially due to its pristine, undisturbed natural character. On the base of large material (89 stations located throughout the fjord and 129 Van Veen grab samples) collected during cruises of RVOceaniain July in 2002, 2003, 2005 and 2007 and literature search a comprehensive list of species recorded within Hornsund area, on the soft bottom with depth range of 30-250 m is provided. Over 220 species were identified including 93 species of Polychaeta, 62 species of Mollusca and 58 species of Crustacea. Species list is supported by information on the zoogeographical status, body length and biological traits of dominant species. Need for further research on Hornsund soft bottom fauna with more sampling effort is highlighted.
Summer 2009 thermal and bioclimatic conditions in Ebba Valley, central Spitsbergen
Authors: Bednorz Ewa , Kolendowicz Leszek 
Published: December 2010

Summer 2009 thermal and bioclimatic conditions in Ebba Valley, central Spitsbergen
The thermal, anemometric and bioclimatic conditions on the topoclimatic scale were investigated in the summer season in the EbbaValley region in central Spitsbergen. Eight measurement sites, representing different ecosystems and different types of active surfaces typical of Spitsbergen, were chosen and automatic, hourly recorded, measurements were performed at the sites between 11 and 25 of July 2009. The analysis of the spatial distribution of the air temperature and thewind-chill temperature, both for the dayswith radiation and non-radiation weather, indicates that the most favorable regions in the interior of Spitsbergen are those situated in the shielded central parts of the valleys and in the lower parts of the slopes with southern exposure. The thermal and wind conditions are definitely less favorable at the tops of elevations and on the glacier. Large differences between the air temperature and the wind-chill temperature were noted, particularly during the unfavorable non-radiation weather, on the glacier and on open peaks due to a large horizontal and vertical wind-chill temperature gradient. The thermal inversions observed in the Ebba Valley in July 2009 were not of the typical, glacier katabatic wind origin. They appeared during the western air circulation, which brings advection of cooled air from above the cold waters of Petunia Bay. The cold air penetrates into the valley and pushes upwards themass of warmer air in the valley, creating a rather thin inversion layer, whose upper edge is marked with thin Stratus clouds.
The Effect of Low Dose Ionizing Radiation and Cadmium Chloride on Glucose Metabolism in Broiler Chickens
Authors: Daňová Denisa , Kafka Igor , Kaleničová Zuzana , Nováková Jaroslava 
Published: December 2010

The aim of the study was to observe the effect of ionizing radiation and cadmium chloride on glucose metabolism in broiler chickens. The experiment was conducted on 28-day-old chickens divided into four groups (A, B, C and D). The first group (A) served as control, groups 2 (B) and 3 (C) were irradiated with a single, whole body dose of gamma rays (3 Gy, input 1.14 Gy·min-1) and group 3 (C) was administered a water solution of CdCl2 intraperitoneally at a dose of 6 mg·kg-1 body weight. Group 4 (D) was administered a water solution of CdCl2 intraperitoneally at the same dose as group 3 but chickens of this group were not irradiated with gamma rays. The serum glucose concentration in the chickens that were irradiated and administered CdCl2 solution (C) was decreased significantly (p < 0.05) on days 7, 14 and 21 (p < 0.01) of the experiment compared to control (A). The serum glucose concentration in the chickens administered only CdCl2 (D) was decreased significantly on day 7 compared to control (A). No significant changes in serum glucose concentrations were observed in the remaining group. The results of our experiment indicate that a combined influence of ionizing radiation and administered cadmium chloride resulted in a significant decrease in serum glucose concentration and the influence was more evident than that caused either by cadmium chloride or irradiation alone. The changes in serum glucose concentration observed on days 7 and 14 in gamma-irradiated chickens were lower than those induced only by administration of cadmium chloride.
Fucoidan Therapy Decreases the Proviral Load in Patients with Human T-Lymphotropic Virus Type-1-Associated Neurological Disease
Authors: Araya Natsumi , Takahashi Katsunori , Sato Tomoo , Nakamura Tatsufumi , Sawa Chika , Hasegawa Daisuke , Ando Hitoshi , Aratani Satoko , Yagishita Naoko , Fujii Ryoji , Oka Hiroshi , Nishioka Kusuki , Nakajima Toshihiro , Mori Naoki , Yamano Yoshihisa 
Published: December 2010

Background Human T-lymphotropic virus type-1 (HTLV-1) is a human retrovirus that causes HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) and adult T-cell leukaemia (ATL). A higher viral load in individuals with HTLV-1 infection increases their risk of developing HAM/TSP and ATL. Moreover, the high proviral load is associated with the clinical progression of HAM/TSP. Reduction of the number of HTLV-1-infected cells is therefore crucial for preventing and treating HTLV-1-associated diseases. Recently, fucoidan, a complex sulphated polysaccharide derived from marine seaweed, has been demonstrated to exert inhibitory effects on HTLV-1 infection in vitro. In this study, we examined the in vivo effects of fucoidan on HTLV-1 infection. Methods In this single-centre open-label trial, 13 patients with HAM/TSP were treated with 6 g fucoidan daily for 6–13 months. The HTLV-1 proviral DNA load and frequencies of HTLV-1-specific CD8+ T-cells, natural killer cells, invariant natural killer T-cells and dendritic cells in the peripheral blood were analysed. Furthermore, the in vitro inhibitory effect of fucoidan on cell-to-cell HTLV-1 infection was examined by using luciferase reporter cell assays. Results Fucoidan inhibited the cell-to-cell transmission of HTLV-1 in vitro. Furthermore, fucoidan therapy resulted in a 42.4% decrease in the HTLV-1 proviral load without affecting the host immune cells. During the treatment, no exacerbation was observed. Four patients with HAM/TSP developed diarrhoea, which improved immediately after stopping fucoidan administration. Conclusions Fucoidan is a new potential therapeutic agent for the prevention and treatment of HTLV-1-associated diseases.
Deficiency of IL-22 Contributes to a Chronic Inflammatory Disease: Pathogenetic Mechanisms in Acne Inversa
Authors: Wolk Kerstin , Warszawska Katarzyna , Hoeflich Conny , Witte Ellen , Schneider-Burrus Sylke , Witte Katrin , Kunz Stefanie , Buss Annette , Roewert Hans Joachim , Krause Markus , Lukowsky Ansgar , Volk Hans-Dieter , Sterry Wolfram , Sabat Robert 
Published: December 2010

Abstract
Overexpression of the T cell cytokine IL-22 is linked to the development of some chronic diseases, but little is known about IL-22 deficiency in humans. As demonstrated in this study, acne inversa (AI; also designated as Hidradenitis suppurativa) lesions show a relative deficiency of IL-22 and IL-20, but not of IL-17A, IL-26, IFN-γ, IL-24, or IL-1β. Moreover, AI lesions had reduced expression of membranous IL-22 and IL-20 receptors and increased expression of the natural IL-22 inhibitor, IL-22 binding protein. AI is a chronic inflammatory skin disease with prevalence up to 4% of the population and in which cutaneous bacterial persistence represents an important pathogenetic factor. Accordingly, we also found a relative deficiency of antimicrobial proteins (AMPs) in AI lesions and a positive correlation between lesional IL-22 and IL-20 versus AMP levels. IL-22, like its tissue cell downstream mediator IL-20, upregulated AMPs in reconstituted human epidermis and was critical for increased AMP levels under inflammatory conditions. The relative IL-22 deficiency in AI was not linked to lesional T cell numbers or Th22/Th1/Th17 subset markers and -inducing cytokines. However, IL-10 was highly expressed in AI lesions and correlated negatively with IL-22 expression. Moreover, IL-10 inhibited IL-22 but not IL-17 production in vitro. The IL-10 overexpression, in turn, was not associated with an elevated presence of regulatory T cells but with the enhanced presence of an IL-10–inducing cytokine. We conclude that IL-22 deficiency may contribute to the pathogenesis of certain chronic disorders as postulated in this paper for AI.
Retinoic Acid-Induced CCR9 Expression Requires Transient TCR Stimulation and Cooperativity between NFATc2 and the Retinoic Acid Receptor/Retinoid X Receptor Complex
Authors: Ohoka Yoshiharu , Yokota Aya , Takeuchi Hajime , Maeda Naoko , Iwata Makoto 
Published: December 2010

Abstract
Retinoic acid (RA) imprints gut-homing specificity on T cells upon activation by inducing the expression of chemokine receptor CCR9 and integrin α4β7. CCR9 expression seemed to be more highly dependent on RA than was the α4β7 expression, but its molecular mechanism remained unclear. In this article, we show that NFAT isoforms NFATc1 and NFATc2 directly interact with RA receptor (RAR) and retinoid X receptor (RXR) but play differential roles in RA-induced CCR9 expression on murine naive CD4+ T cells. TCR stimulation for 6–24 h was required for the acquisition of responsiveness to RA and induced activation of NFATc1 and NFATc2. However, RA failed to induce CCR9 expression as long as TCR stimulation continued. After terminating TCR stimulation or adding cyclosporin A to the culture, Ccr9 gene transcription was induced, accompanied by inactivation of NFATc1 and sustained activation of NFATc2. Reporter and DNA-affinity precipitation assays demonstrated that the binding of NFATc2 to two NFAT-binding sites and that of the RAR/RXR complex to an RA response element half-site in the 5′-flanking region of the mouse Ccr9 gene were critical for RA-induced promoter activity. NFATc2 directly bound to RARα and RXRα, and it enhanced the binding of RARα to the RA response element half-site. NFATc1 also bound to the NFAT-binding sites and directly to RARα and RXRα, but it inhibited the NFATc2-dependent promoter activity. These results suggest that the cooperativity between NFATc2 and the RAR/RXR complex is essential for CCR9 expression on T cells and that NFATc1 interferes with the action of NFATc2.
Successful Colon Cancer Eradication after Chemoimmunotherapy Is Associated with Profound Phenotypic Change of Intratumoral Myeloid Cells
Authors: Medina-Echeverz José , Fioravanti Jessica , Zabala Maider , Ardaiz Nuria , Prieto Jesús , Berraondo Pedro 
Published: December 2010

Abstract
IL-12 is a potent immunostimulatory cytokine, but its impact as an antitumor drug in clinical practice is limited. Upsurge of regulatory T cells (Treg) in the tumor milieu has been proposed to limit the efficacy of the treatment. In this paper, two drugs (cyclophosphamide [CPA] and anti-CD25 mAb) widely used to eliminate Treg were used in an attempt to enhance the antitumor effect of IL-12 gene therapy. Both anti-CD25 and CPA combined with IL-12 were able to deplete intratumoral Treg and myeloid-derived suppressor cells (MDSC), but only IL-12 plus CPA achieved significant antitumor activity in mice with large established s.c. colon carcinoma. This therapeutic effect was associated with the emergence of a heterogeneous population of myeloid cells within the tumor, termed inflammatory myeloid cells (IMC), composed of Ly6ChighLy6Glow inflammatory monocytes and Ly6GhighLy6C+ neutrophils. IMC showed a distinctive pattern of cytokine/chemokine production, and in contrast to MDSC, they did not induce conversion of naive CD4+ T cells into Treg. The appearance of IMC coincided with intense tumor infiltration by effector T cells, which was abrogated by elimination of IMC by anti-Gr1 mAb, a maneuver that abolished the antitumor effect of the therapy. Therefore, the combination of IL-12 and CPA eliminates intratumoral Treg and MDSC, while it induces the appearance of IMC within the tumor microenvironment. The latter effect is essential to facilitate effector T cell infiltration and subsequent tumor elimination.