bluuebunny/crossref_metadata_2025_split huggingface dataset:
Children's psychological distress during pediatric HSCT: Parent and child perspectives
Authors: Chang Grace , Ratichek Sara J. , Recklitis Christopher , Syrjala Karen , Patel Sunita K. , Harris Lynnette , Rodday Angie Mae , Tighiouart Hocine , Parsons Susan K. 
Published: May 2011

AbstractBackgroundHematopoietic stem cell transplantation (HSCT) can be challenging to pediatric recipients and their families. Little is known about the recipients' psychological status as they initiate treatment and in the year afterwards. The purpose of this study is to describe the psychological status of 107 pediatric HSCT recipients from their parents' perspective, and to compare reports from parents and children in a subset of 55 children. We hypothesized that there would be discrepancies between parent and child report of child distress.ProcedureMulti‐site, prospective study of eligible child participants and their parents who completed selected modules from the Structured Clinical Interview for DSM‐IV‐TR, Childhood Version (KID‐SCID) the month before and one year after HSCT. Diagnoses were threshold or subthreshold.ResultsAccording to parents, nearly 30% of children had anxiety disorder both before and after HSCT; approximately half of these met threshold criteria. Agreement between parents and children for anxiety disorders was poor at baseline (κ = −0.18, 95%CI = −0.33, −0.02) and fair at 12 months (κ = 0.31, 95%CI = −0.04, 0.66). Agreement about mood disorders was fair at baseline (10% prevalence, κ = 0.39, 95%CI = −0.02, 0.79) and moderate at 12 months (14% prevalence, κ = 0.41, 95%CI = 0.02, 0.80).ConclusionsAnxiety (30%) and mood (10–14%) symptoms are common in children both before and after HSCT; parent and child reports of these symptoms do not agree. Input from parents and children is recommended to identify more accurately children who may need additional intervention during and following HSCT Pediatr Blood Cancer 2012; 58: 289–296. © 2011 Wiley Periodicals, Inc.
Ofatumumab for a rituximab‐allergic child with chronic‐relapsing paraneoplastic opsoclonus–myoclonus
Authors: Pranzatelli Michael R. , Tate Elizabeth D. , Shenoy Shalini , Travelstead Anna L. 
Published: May 2011

AbstractOfatumumab is a fully human anti‐CD20 monoclonal antibody in phase II–III trials for various autoimmune and lymphoreticular diseases. We used it to treat a rituximab‐allergic child with severe, chronic‐relapsing, opsoclonus–myoclonus syndrome (OMS), characterized by persistent cerebrospinal fluid (CSF) B‐cell expansion and T‐cell dysregulation. He had relapsed despite chemotherapy, plasma exchange with immunoadsorption, and resection of ganglioneuroblastoma, detected 3 years after OMS onset. The four ofatumumab infusions (1,195 mg/m2 total dose) were well tolerated, and CSF B‐cell expansion was eliminated. No further relapses have occurred in 3 years, but he remains on low‐dose ACTH with neuropsychiatric residuals of OMS. Pediatr Blood Cancer 2012; 58: 988–991. © 2011 Wiley Periodicals, Inc.
Cost‐effectiveness of treatment of childhood acute lymphoblastic leukemia with chemotherapy only: The influence of new medication and diagnostic technology
Authors: van Litsenburg Raphaële R.L. , Uyl‐de Groot Carin A. , Raat Hein , Kaspers Gertjan J.L. , Gemke Reinoud J.B.J. 
Published: May 2011

AbstractBackgroundSurvival for childhood acute lymphoblastic leukemia (ALL) has reached 80–90%. Future improvement in treatment success will involve new technologies and medication, adding to the pressure on limited financial resources. Therefore a retrospective cost‐effectiveness analysis of ALL treatment with chemotherapy only according to the two most recent Dutch Childhood Oncology Group treatment protocols was performed. The most recent protocol ALL10 included more expensive medication (pegasparaginase) and implemented a new diagnostic technique (minimal residual disease levels) compared to the previous ALL9 protocol.ProcedureFifty children from a single center cohort were included. All direct medical costs made during treatment, including those in satellite hospitals, were determined. Costs per life year saved (LYS) were calculated. The cost‐effectiveness ratio of the most recent treatment protocol was determined. LYS were calculated based on national 5‐year event‐free survival.ResultsMean total costs were between $115,858 (ALL9) and $163,350 (ALL10) per patient. Hospital admissions (57%) and medication (11–17%) were important drivers of overall costs, and were higher in the most recent protocol ALL10. Costs per LYS were $1,962 (ALL9) and $2,655 (ALL10) and the cost‐effectiveness ratio was $8,215.ConclusionTreatment of childhood ALL with chemotherapy only is well within accepted ranges of cost‐effectiveness. The use of new technology and more expensive medication in the most recent protocol ALL10 lead to higher costs but more LYS. In future (ALL) treatment protocols, costs in relation to effects should be taken into account in order to establish more cost‐effective disease management without jeopardizing survival and quality of life. Pediatr Blood Cancer 2011; 57: 1005–1010. © 2011 Wiley‐Liss, Inc.
Transformed in situ fabrication of macroporous carbon network structures from egg membranes and its biomacromolecule adsorption
Authors: Lin Lin , Yuan Pinshi , Wu Qingsheng , Xie Jinsong 
Published: May 2011

AbstractNovel carbon material with hierarchical porous network structures was made by a method of transformed in situ route based on eggshell membrane (ESM) under inert atmosphere. The structural, physical, and chemical properties were characterized by scanning electron microscopy, Brunauer‐Emmett‐Teller, and UV–visible. The results showed that materials were crosslinked with fibers in diameters ranging from 0.3 to 0.9 μm to form a network. Furthermore, the ESMs were modified to prepare ordered macroporous materials with average pore size of 1 μm. The macroporous materials were evaluated through the adsorption properties of Pb2+ and bovine serum albumin, indicating good selectivity of macromolecules compared with commercial activated carbon. Pore structure analysis indicated that pore size is an important factor on improving the adsorbing macromolecules ability. The materials holding mixed three‐dimensional networks provide favorable transport channels for macromolecules. POLYM. COMPOS., 2011. © 2011 Society of Plastics Engineers
Phenomenological model of interfacial stress transfer in carbon nanotube reinforced composites with van der Waals effects
Authors: Zhou Li‐Jun , Kang Yi‐Lan , Guo Jian‐Gang 
Published: May 2011

AbstractA pullout model is presented to analyze interfacial stress transfer in the double‐walled carbon nanotube (DWCNT) reinforced composites. The effects of the van der Waals (vdW) interaction between two layers of DWCNT and the Poisson's effects of DWCNT and matrix are taken into account in the model. Based on the equilibrium of the interfacial shear stress and the DWCNT axial stress as well the continuous condition of the displacement and stress on the interface of DWCNT and matrix, normalized interfacial shear stress, DWCNT axial stress and matrix axial stress are derived, respectively. Moreover, the effects of DWCNT aspect ratio, DWCNT volume fraction and relative modulus between the DWCNT and matrix are analyzed in details. Finally, the maximum normalized interfacial shear stress with vdW effect is compared with that without vdW effects. POLYM. COMPOS., 2011. © 2011 Society of Plastics Engineers
High‐performance nanocomposites derived from allyl‐terminated benzoxazine and octakis(propylglycidyl ether) polyhedral oligomeric silsesquioxane
Authors: Huang Kai‐Wei , Kuo Shiao‐Wei 
Published: May 2011

AbstractIn this study, we used the Mannich condensation of bisphenol A, formaldehyde, and allylamine to synthesize a allyl‐terminated benzoxazine (VB‐a), which can be polymerized through ring opening polymerization. We used this VB‐a monomer, blended with octakis(propylglycidyl ether) polyhedral oligomeric silsesquioxane (OG‐POSS), to prepare polybenzoxazine/POSS nanocomposites. Differential scanning calorimetry and Fourier transform infrared (FTIR) spectroscopy revealed that the mechanism of the crosslinking reaction leading to the formation of the organic/inorganic network involved two steps: (i) ring opening and allyl polymerizations of VB‐a and (ii) subsequent reactions between the in situ‐formed phenolic hydroxyl groups of VB‐a and the epoxide groups of OG‐POSS. Dynamic mechanical analysis revealed that the nanocomposites had higher mechanical properties than did the control VB‐a. In the glassy state, nanocomposites containing less than 10 wt % POSS displayed enhanced storage moduli; those of the nanocomposites containing greater than 10 wt % POSS were relatively low, due to aggregation, as determined using scanningelectron microscopy. Thermogravimetric analysis indicated that the nanocomposites possessed greater thermal stability than that of the pure polymer. FTIR spectroscopic analysis revealed the presence of hydrogen bonding between the siloxane groups of POSS and the OH groups of the polybenzoxazine. POLYM. COMPOS., 2011. © 2011 Society of Plastics Engineers
Classification of Greek Mentha pulegium L. (Pennyroyal) Samples, According to Geographical Location by Fourier Transform Infrared Spectroscopy
Authors: Kanakis Charalabos D. , Petrakis Eleftherios A. , Kimbaris Athanasios C. , Pappas Christos , Tarantilis Petros A. , Polissiou Moschos G. 
Published: May 2011

ABSTRACTIntroductionMentha pulegium L. (pennyroyal) is one of the four most commercially important Mentha species, even it is not a cultivated plant. It can be abundantly located in the Iberian Peninsula and North African countries. In Greece it grows in the wild and it is scattered all over the country. Pennyroyal is best known for its essential oil, with Spain and Morocco being the largest producers in the world. Mid‐infrared spectroscopy has been applied to determine the origin of various samples.ObjectivesIn this work Fourier transform infrared spectroscopy (FT‐IR) combined with canonical discriminant analysis has been applied to distinguish 70 Greek pennyroyal samples according to their collection areas.Material and methodsPennyroyal nonpolar organic extracts were prepared using ultrasound‐assisted solvent extraction. The spectra of the extracts were recorded in the range of 4000–400 cm−1 and the best discrimination was achieved in the spectral region 1720–1650 cm−1.ResultsSpectral features for the discrimination of pennyroyal samples among the different collection areas occur primarily in the carbonyl region and are correlated with the main volatile constituents of the extracts (menthone, isomenthone, pulegone, piperitone). All areas were easily differentiated by canonical discriminant analysis. The percentages of correct classification and validation were 94.3 and 90.0%, respectively.ConclusionThe combination of FT‐IR spectroscopy and multivariate analysis provides a rapid and ambient method to discriminate pennyroyal samples in terms of geographical origin. Copyright © 2011 John Wiley & Sons, Ltd.
Simultaneous Determination of Eight Anthraquinones in Semen Cassiae by HPLC‐DAD
Authors: Xu Lijia , Chan Chi‐on , Lau Ching‐ching , Yu Zhiling , Mok Daniel K. W. , Chen Sibao 
Published: May 2011

ABSTRACTIntroductionSemen Cassiae (SC), a traditional Chinese herbal medicine for the treatment of various diseases, is known to contain active anthraquinone ingredients. However, since the content of some anthraquinones is too low, previous analytical methods only allow the quantitation of a few anthraquinones or a hydrolysis step has to be included in the sample preparation. A rapid and accurate method to examine the content of as many anthraquinones as possible in SC would be desirable.ObjectiveTo develop a rapid, sensitive and accurate high‐performance liquid chromatography–diode array detection (HPLC‐ DAD) method to simultaneously quantify eight major anthraquinones (obtusifolin‐2‐glucoside, aurantio‐obtusin, aloe‐ emodin, rhein, obtusifolin, emodin, chrysophanol and physcion) in SC.MethodologyThe separation of anthraquinones was achieved on a C18‐column with a gradient elution using acetonitrile and 0.1% phosphoric acid. The detection wavelength was 278 nm and the analysis finished within 25 min.ResultsThe limits of detection of these compounds ranged from 0.07 to 0.15 µg/mL while the limits of quantitation ranged from 0.24 to 0.51 µg/mL. All calibration curves showed good linearities (r2 > 0.999) within the test ranges. This validated method was successfully used to analyse 22 batches of SC samples collected from various geographical locations.ConclusionThe method was validated to be simple, rapid, accurate and reliable to simultaneously determine eight major anthraquinones in SC. Meanwhile, a more specific anthraquinone, obtusifolin, was proposed to serve as a marker for SC, replacing chrysophanol. Copyright © 2011 John Wiley & Sons, Ltd.
Study of the crystalline phase orientation in uniaxially stretched polypropylene by Raman spectroscopy: Validation and use of a time‐resolved measurement method
Authors: Martin Julien , Ponçot Marc , Bourson Patrice , Dahoun Abdesselam , Hiver Jean‐Marie 
Published: May 2011

AbstractThis study proposes an experimental method to quantify the molecular orientation of the crystalline phase of isotactic polypropylene from polarized Raman spectroscopy measurements. The method is based on the intensity sensitivity of two Raman scattering bands located at 973 (C‐C stretching mode) and 998 cm−1 (CH3 rocking mode) to laser light polarization. The first part of this article is devoted to the validation of the method by comparing Raman and Wide Angle X‐ray Scattering (WAXS) results obtained on postmortem test samples uniaxially deformed at growing levels. Second, the method is applied to follow the molecular orientation in situ during a tensile test by combining a video‐controlled test machine and a Raman spectrometer. Postmortem results show a quantitative agreement between Raman and WAXS measurements. In situ results mainly evidence the ability of the Raman method to characterize molecular orientation in real‐time with less than 5 s time resolution. POLYM. ENG. SCI., 2011. ©2011 Society of Plastics Engineers .
Electro‐tuning of surface state in two‐dimensional photonic crystals
Authors: Vala Ali Soltani , Rezaei Emad , Hoseini Naser , Barvestani Jamal 
Published: May 2011

AbstractIn this paper, we have investigated the electro‐tuning of surface states in two‐dimensional square lattice photonic crystal (PC) of circular air holes in alumina background in which one row of the outermost air holes is infiltrated by a nematic liquid crystal (NLC). By minimizing the total (elastic plus electromagnetic) free energy, the configuration of the NLC directors, as a function of radial distance can be obtained. This configuration determines the dielectric tensor as function of radial distance. Therefore, by use of supercell method, dependence of surface states on applied electrical field has been studied. Numerical results show that position of surface modes can be effectively controlled by applying an external field on liquid crystal rods.
Electrical properties and carrier transport mechanisms of nonvolatile memory devices based on randomly oriented ZnO nanowire networks
Authors: Wang H. J. , Zou C. W. , Zhou L. , Tian C. X. , Lee M. K. , Lee J. C. , Kang T. W. , Fu D. J. 
Published: May 2011

AbstractWe report reproducible bipolar resistive memory devices based on Au/ZnO nanowire networks (ZnO NWNs)/ITO, which show a high Ron/Roff ratio (∼104) and narrow dispersion of set and reset threshold voltages. The dominant conduction mechanisms of low resistance state and high resistance state were verified by Ohmic behavior and space charge limited current, respectively. The switching mechanism is confirmed in terms of the formation and rupture of conductive filaments, with oxygen vacancies localized on the ZnO NWNs surface involved in. The Au/ZnO NWNs/ITO devices presented in our work show potential applications in the next generation nonvolatile memory field. (© 2011 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Diallyl Disulfide Induces MUC5B Expression via ERK2 in Human Airway Epithelial Cells
Authors: Bae Chang Hoon , Kwak Dong Suk , Ye Sang Baik , Song Si‐Youn , Kim Yong‐Dae 
Published: May 2011

Garlic has been shown to have antimicrobial, hypolipidemic, antithrombotic, antitumor and immunostimulatory properties. The medicinal effects of garlic are derived from the flavonoid and organosulfur components. Diallyl disulfide (DADS), an organosulfur, is the main component responsible for the diverse biological effects of garlic. However, the effects of DADS on mucin gene expression in airway epithelial cells have not been reported to date. Therefore, this study was performed to investigate the effects and brief signaling pathway of DADS associated with MUC5B expression in NCI‐H292 epithelial cells using RT‐PCR, ELISA, western blot, immunocytochemistry and cell transfection with siRNA.DADS induced MUC5B expression and activated the phosphorylation of ERK1/2 MAPK. In addition, U0126 inhibited DADS‐induced MUC5B expression and DADS‐activated phosphorylation of ERK1/2 MAPK. Moreover, the immunopositive cells for MUC5B protein did not appear after treatment of DADS with U0126, and the knockdown of ERK2 MAPK by ERK2 MAPK siRNA significantly blocked DADS‐induced MUC5B mRNA expression. However, DADS did not activate the phosphorylation of p38 MAPK, and SB203580 did not inhibit DADS‐induced MUC5B expression.This is the first study to show that DADS‐induced MUC5B expression appears to be regulated by activation of the ERK2 MAPK signaling pathway in human NCI‐H292 airway epithelial cells. Copyright © 2011 John Wiley & Sons, Ltd.
New Quality Level of Packaging Components from Paperboard through Technology Improvement in 3D Forming
Authors: Hauptmann Marek , Majschak Jens‐Peter 
Published: May 2011

SUMMARYThree‐dimensional forming is a key technology for the application of sustainable materials, like paperboard, in packaging technology. Until now, deep drawing is not considered as a suitable process for manufacturing of packaging components with advanced geometrical design because of the sensitive process and a large number of failure mechanisms. To better understand and apply the physics of deep drawing, the process was studied by experimental investigations. Therefore, an evaluation strategy for formed parts was developed to describe their quality by measurable values. The influence of the technological parameters temperature configuration, moisture content of material and blank holder force on the quality of formed parts was described by a statistic regression model. This model gives an indication of the quantity and the direction of effects that parameter changes have on the quality of 3D‐formed parts. An optimization of the process according to quality criteria showed that, in a first step, the quality of cylindrically drawn paperboard parts was increased drastically compared with that of the state of the art. Furthermore, the existing limits in the height of formed parts were exceeded, and the geometrical shape of the base offered far more opportunities for packaging design than expected. The process turned out to be suitable for a flexible manufacturing of packaging components for multipart packages from paperboard, which are highly sustainable in terms of recycling and reuse of fibres and thereby able to compete in the marketing‐oriented packaging sector. Copyright © 2011 John Wiley & Sons, Ltd.
Measurement of the Oxygen Transmission Rate of Co‐extruded Wine Bottle Closures Using a Luminescence‐Based Technique
Authors: Diéval Jean‐Baptiste , Vidal Stéphane , Aagaard Olav 
Published: May 2011

The oxygen transmission rate (OTR) is a value commonly measured in different industries to evaluate oxygen flow through all types of packaging. The Mocon® Ox‐tran® method (Mocon Inc., Minneapolis, MN, USA) for measuring OTR is globally accepted and is recommended in different standards such as the ASTM (F1307‐02), but in practice, only a limited number of samples can be analysed, and the stabilisation of the measurement takes time.In this paper, a simple, non‐destructive technique allowing measurement of co‐extruded closure OTR is presented. The established protocol allows measurement of oxygen ingress through the closures or at the interface between closures and bottleneck and avoids possible leakages that can happen when bottlenecks are glued onto metallic plates. Oxygen permeating in the bottle is measured by a luminescence‐based technology using separate sensors supplied by PreSens® (Precision Sensing GmbH, Regensburg, Germany).The simple set‐up and the use of a non‐destructive luminescence‐based technology make this an easy test to perform. Moreover, the development of a predictive model allows us to reduce the analysis time to one week. Comparison with the well‐established Mocon Ox‐tran method shows good accordance between the two techniques. This new method allows the measurement of more samples in less time without compromising analytical performance. This method could become a useful quality control procedure in the wine industry to assess OTR performances of closures. Copyright © 2011 John Wiley & Sons, Ltd.
Stability analysis and control synthesis of switched impulsive systems
Authors: Xiang Weiming , Xiao Jian 
Published: May 2011

SUMMARYIn this paper, we investigate the stability analysis problem of switched impulsive nonlinear systems and several stabilization problems of switched discrete‐time linear systems are studied. First, sufficient conditions ensuring globally uniformly asymptotically stability of switched nonlinear impulsive system under arbitrary and DDT (dynamical dwell time which defines the length of the time interval between two successive switchings) switching are derived, respectively. In the DDT switching case, we first consider the switched system composed by stable subsystems, then we extend the results to the case where not all subsystems are stable. The stabilizations of switched discrete‐time linear system under arbitrary switching, DDT switching and asynchronous switching are investigated respectively. Based on the stability analysis results, the control synthesis consists of controller design for each subsystem and state impulsive jumping generators design at switching instant. With the aid of the state impulsive jumping generators at switching instant, the ‘energy’ produced by switching can be minimized, which leads to less conservative results. Several numerical examples are given to illustrate the proposed results within this paper. Copyright © 2011 John Wiley & Sons, Ltd.