bluuebunny/crossref_metadata_2025_split huggingface dataset:
Efficacy and safety of angiotensin receptor blockade are not modified by aspirin in patients with chronic heart failure: a cohort study from the Candesartan in Heart failure – Assessment of Reduction in Mortality and morbidity (CHARM) programme
Authors: Chang Su Min , Granger Christopher B. , Johansson Peter A. , Kosolcharoen Peter , McMurray John J.V. , Michelson Eric L. , Murray David R. , Olofsson Bertil , Pfeffer Marc A. , Solomon Scott D. , Swedberg Karl , Yusuf Salim , Dunlap Mark E. ,   for the CHARM Investigators
Published: April 2010

AimsIt is unknown whether there is an interaction between aspirin and angiotensin receptor blockers on outcomes in patients with heart failure (HF).Methods and resultsThe efficacy and safety of candesartan vs. placebo was assessed in 7599 patients with symptomatic HF and reduced or preserved left ventricular ejection fraction enrolled in the CHARM programme according to baseline aspirin use. Patients were randomized to candesartan or matching placebo and were followed for a median of 38 months. Aspirin was used in 4246 (55.9%) of patients at baseline. When compared with placebo, candesartan use was associated with lower event rates for cardiovascular (CV) death or HF hospitalization (primary outcome) in both the aspirin group (28 vs. 31.9%, HR 0.81, 95% CI 0.72–0.90) and non‐aspirin group (33 vs. 38%, HR 0.81, 95% CI 0.72–0.91). Baseline aspirin use did not modify the effectiveness of candesartan in reducing the risk of CV death or HF hospitalization in CHARM overall (P = 0.64) or in the CHARM individual trials. In addition, there was no significant interaction between aspirin therapy and candesartan in terms of discontinuation of study drug due to adverse reactions (P = 0.72).ConclusionThere appears to be no significant modification of the benefit of candesartan on CV mortality and morbidity outcomes or safety by concomitant use of aspirin in patients with chronic HF.
The Arabidopsis Chaperone J3 Regulates the Plasma Membrane H+-ATPase through Interaction with the PKS5 Kinase
Authors: Yang Yongqing , Qin Yunxia , Xie Changgen , Zhao Feiyi , Zhao Jinfeng , Liu Dafa , Chen Shouyi , Fuglsang Anja T. , Palmgren Michael G. , Schumaker Karen S. , Deng Xing Wang , Guo Yan 
Published: April 2010

Abstract
The plasma membrane H+-ATPase (PM H+-ATPase) plays an important role in the regulation of ion and metabolite transport and is involved in physiological processes that include cell growth, intracellular pH, and stomatal regulation. PM H+-ATPase activity is controlled by many factors, including hormones, calcium, light, and environmental stresses like increased soil salinity. We have previously shown that the Arabidopsis thaliana Salt Overly Sensitive2-Like Protein Kinase5 (PKS5) negatively regulates the PM H+-ATPase. Here, we report that a chaperone, J3 (DnaJ homolog 3; heat shock protein 40-like), activates PM H+-ATPase activity by physically interacting with and repressing PKS5 kinase activity. Plants lacking J3 are hypersensitive to salt at high external pH and exhibit decreased PM H+-ATPase activity. J3 functions upstream of PKS5 as double mutants generated using j3-1 and several pks5 mutant alleles with altered kinase activity have levels of PM H+-ATPase activity and responses to salt at alkaline pH similar to their corresponding pks5 mutant. Taken together, our results demonstrate that regulation of PM H+-ATPase activity by J3 takes place via inactivation of the PKS5 kinase.
The effect of dyslexia on information retrieval
Authors: MacFarlane A. , Al‐Wabil A. , Marshall C.R. , Albrair A. , Jones S.A. , Zaphiris P. 
Published: April 2010

PurposeThe purpose of this paper is to resolve a gap in the knowledge of how people with dyslexia interact with information retrieval (IR) systems, specifically an understanding of their information‐searching behaviour.Design/methodology/approachThe dyslexia cognitive profile is used to design a logging system, recording the difference between two sets of participants: dyslexic and control users. A standard Okapi interface is used – together with two standard TREC topics – in order to record the information searching behaviour of these users.FindingsUsing the log data, the differences in information‐searching behaviour of control and dyslexic users, i.e. in the way the two groups interact with Okapi, are established and it also established that qualitative information collected (such as experience etc.) may not be able to account for these differences. Evidence from query variables was unable to distinguish between groups, but differences on topic for the same variables were recorded. Users who view more documents tended to judge more documents as being relevant, in terms of either the user group or topic. Session data indicated that there may be an important difference between the number of iterations used in a search between the user groups, as there may be little effect from the topic on this variable.Originality/valueThis is the first study of the effect of dyslexia on information search behaviour, and it provides some evidence to take the field forward.
Creativity and craft: the information‐seeking behavior of theatre artists
Authors: Medaille Ann 
Published: April 2010

PurposeThe aim of this study is to explore the information needs and behaviors of practicing theatre artists. Psychological research into creativity provides a framework for understanding both theatre artists' information‐seeking behavior and the role of information seeking and gathering in the creative process.Design/methodology/approachThe exploratory study presents findings from an online questionnaire of 73 practicing theatre artists and qualitative data gathered from eight interviews with theatre professionals.FindingsThe study reveals that theatre artists seek information for six primary purposes: understanding a work's historical, cultural, and critical background; finding sources of inspiration; learning about contemporary or historical theatre productions, artists, and events; learning technical or process information; finding performance materials; and furthering career goals. Theatre artists view the information search process as being essential to their creative activities, and their first‐hand accounts of their artistic experiences illuminate the critical role that information seeking and gathering play in the creative process.Research limitations/implicationsSome theatre professions, such as lighting or sound design, were represented in the questionnaire but were not represented in the interviews.Practical implicationsThe study has practical implications for the delivery of library and internet theatre art collections and information services.Originality/valueFew studies have examined the information‐seeking behavior of practicing theatre artists. The paper demonstrates that studies of artists can be used to understand the role of information seeking and gathering in the creative processes of people working in various subject domains.
Information about the synthesis of life forms: a document‐oriented approach
Authors: Kouper Inna 
Published: April 2010

PurposeThis study aims to examine the forms of information about the synthesis of life forms in the public sphere.Design/methodology/approachA document‐oriented approach was used and a wide range of documents that discuss a particular technoscientific issue was sampled. The analysis of documents involved a combination of discourse and content analysis.FindingsThe study demonstrates that there is a significant growth of the diversity of document types over time. Overall, 24 document types and 21 publication formats were identified. Web‐based formats, such as blogs and news and information web sites, play a prominent role in the dissemination of information about the synthesis of life forms.Research limitations/implicationsThe variety of document types identified here expands current understanding of the public documentary landscape and shows that the analysis of technoscientific debates and controversies can no longer be limited to traditional mass media documents such as news, feature articles, and editorials. However, a larger sample that includes more documents as well as non‐textual objects, such as images or even lab specimens, would expand the scope of this taxonomy and make conclusions more definitive. Further research into the specific digital types of documents identified in the study and their impact on the communication of scientific information to the public is needed.Practical implicationsSurveying and understanding the kinds of documents that circulate information about emerging technoscientific issues can help to provide better services for a variety of information users and develop better tools for access and dissemination of such information.Originality/valueThe study demonstrates that a document‐oriented approach can provide valuable insight into the circulation of information about science in the public sphere. It also offers an elaborate taxonomy of documents that can be used in further research as well as in information and science literacy instruction.
Scholarly output: print and digital – in teaching and research
Authors: Maynard Sally , O'Brien Ann 
Published: April 2010

PurposeThe purpose of this paper is to report the outcomes of a Joint Information Systems Committee (JISC)‐sponsored study to determine the current state and trends in different forms of scholarly output used in teaching and research; and the nature and extent of problems associated with their use.Design/methodology/approachA total of 60 UK HE institutions were chosen at random and a selection of departments within these was contacted. An online questionnaire was distributed to the selected departments; resulting in responses from 304 academics across a broad range of subjects and institution types.FindingsThe study showed that printed output was still the preferred option in both teaching and research, although electronic journals now have a well‐established presence. Web‐based material is increasingly provided in teaching and used in research but this includes primarily traditional tools such as reading lists and links to scholarly resources. Some content creation was evident. Use of web 2.0 was not extensive, although respondents were making use of Institutional Learning Environments. Academics were aware of Intellectual Property Rights (IPR) issues but not always clear about their responsibilities in this area.Research limitations/implicationsThe study revealed an essentially conservative approach to the developments in digital information. This may have been due to the sample size which was relatively small, and the age profile which clustered around the 45‐65 years range. In the case of research the influence of the Research Assessment Exercise (RAE) was clear.Originality/valueNo equivalent study has been reported on the transition between traditional and new forms of scholarly output used in teaching and research. In this fast developing area this research provides a benchmark for future studies.
Diversity in the e‐journal use and information‐seeking behaviour of UK researchers
Authors: Nicholas David , Rowlands Ian , Huntington Paul , Jamali Hamid R. , Hernández Salazar Patricia 
Published: April 2010

PurposeThe purpose of this paper is to present some of the results of the project “Evaluating the usage and impact of e‐journals in the UK”. The particular research reported here evaluated the use of the ScienceDirect journals database with regard to Life Sciences, Economics, Chemistry, Earth & Environmental Sciences and Physics by ten major UK research institutions. The aim of the study is to investigate researchers' digital behaviour, and to ascertain whether their use and behaviours varied by subjects and disciplines, or in relation to the institutions in which they worked.Design/methodology/approachRaw logs for ScienceDirect were obtained for the period January to April 2007, were subject to deep log techniques and analysed using the Software Package for Social Sciences (SPSS).FindingsTypically, 5 per cent of the ScienceDirect journals viewed accounted for a third to half of all use. A high proportion of researchers entered the ScienceDirect site via a third‐party site, and this was especially so in the case of the Life Sciences and in the highest‐ranked research institutions. There were significant institutional and subject differences in information‐seeking behaviour. In the most research‐intensive institutions, per capita journal use was highest and their users spent much less time on each visit. There were significant differences of the order of 100‐300 per cent in the age of material viewed between subjects and institutions. Just four months after ScienceDirect content was opened to Google indexing, a third of traffic to the site's Physics journals came via that route.Originality/valueThe research is one of the very few studies to investigate subject and institutional differences with regard to the information seeking and use of UK researchers, something UK academic librarians should particularly welcome.
The one‐stop shop search engine: a transformational library technology?
Authors: Joint Nicholas 
Published: April 2010

PurposeThe purpose of this paper is to form one of a series which will give an overview of so‐called “transformational” areas of digital library technology. The aim will be to assess how much real transformation these applications are bringing about, in terms of creating genuine user benefit and also changing everyday library practice.Design/methodology/approachAn overview of the present state of development of the one‐stop shop library search engine, with particular reference to its relationship with the underlying bibliographic databases to which it provides a simplified single interface.FindingsThe paper finds that the success of federated searching has proved valuable but limited to date in creating a one‐stop shop search engine to rival Google Scholar; but the persistent value of the bibliographic databases sitting underneath a federated search system means that a harvesting search engine could well answer the need for a true one‐stop search engine for academic and scholarly information.Research limitations/implicationsThis paper is based on the hypothesis that Google's success in providing such an apparently high degree of access to electronic journal services is not what it seems, and that it does not render library discovery tools obsolete. It argues that Google has not diminished the pre‐eminent role of library bibliographic databases in mediating access to e‐journal text, although this hypothesis needs further research to validate or disprove it.Practical implicationsThe paper affirms the value of bibliographic databases to practitioner librarians and the potential of single interface discovery tools in library practice.Originality/valueThe paper uses statistics from US LIS sources to shed light on UK discovery tool issues.
Of Descartes and of train schedules
Authors: Kohn Roger S. 
Published: April 2010

PurposeThe purpose of this paper is to discuss the second edition of the Encyclopaedia Judaica (2007) within its broader historical context of the production of encyclopedias in the twentieth and the twenty‐first centuries. The paper contrasts the 2007 edition of the Encyclopaedia Judaica to the Jewish Encyclopedia published between 1901 and 1905, and to the first edition of the Encyclopaedia Judaica published in 1972; then contrasts the 2007 edition of the Encyclopaedia Judaica to Wikipedia and to other projects of online encyclopedias.Design/methodology/approachThe paper provides a personal reflective review of the sources in question.FindingsThat Encyclopaedia Judaica in its latest edition does not adequately replace the original first edition in terms of depth of scholarly work. It is considered that the model offered by Wikipedia could work well for the Encyclopaedia Judaica, allowing it to retain the core of the expert knowledge, and at the same time channel the energy of volunteer editors which has made Wikipedia such a success.Practical implicationsThe paper is of interest to those with an interest in encyclopedia design or Jewish studies.Originality/valueThis paper provides a unique reflection on the latest edition of the encyclopedia and considers future models for its publication based on traditional and non‐traditional methods.
Service quality and customer satisfaction in academic libraries
Authors: Kiran Kaur 
Published: April 2010

PurposeThe purpose of this paper is to describe the results of a study to examine the perception of academic staff on the quality of academic library services. It also attempts to assess the impact of library services on their work and their perceived level of satisfaction towards university library services.Design/methodology/approachThe study was carried out using a survey methodology. The survey instrument was a questionnaire adopted from a quality impact survey based on SERVQUAL dimensions.FindingsResults reveal that academic staff perceive the quality of library services to be just above average. Library staff are considered quite helpful and able to instill confidence in library users. Academic staff also believe that the library has a positive impact on their teaching, learning and research. The overall satisfaction with the library services received a satisfactory rating.Research limitations/implicationsThe study is limited to the University of Malaya Library and its branch libraries, thus generalization to other academic libraries is premature at this stage.Practical implicationsThis paper will be helpful to libraries to improve library services, especially in assisting academic staff in teaching and research. Though the quality of library service is perceived as just above average, academics will continue to use the library resources and be dependent on librarians for their information needs.Originality/valueMeasuring service quality is a marketing trend that is gradually proving its worth in library and information science. This study contributes to the growing body of knowledge on service quality measures in academic libraries.
The perspective of e‐learning and libraries in Africa: challenges and opportunities
Authors: Nneka Eke Helen 
Published: April 2010

PurposeThis paper aims to examine and discuss the crucial roles libraries play in e‐learning; the challenges and opportunities facing the e‐learning program and the library's involvement.Design/methodology/approachTo elicit the necessary information, a literature review of studies done on e‐learning and libraries was done. Materials were sourced online and offline to build the literature of this work. The paper gives an overview of e‐learning and types; benefits of e‐learning; the infancy stage of e‐learning, libraries, and e‐learning technologies; starting points for libraries and e‐learning and challenges facing e‐learning.FindingsA lot of challenges are facing the successful implementation of e‐learning in institutions and also the role of libraries in enhancing e‐learning needs a lot of issues to be addressed as library's involvement in e‐learning is found to be very crucial.Practical implicationsThis paper establishes that libraries are the heart of institutions and so, are meant to play a vital role in the learning activities, as well as support all kinds of learning which includes e‐learning. There is also need for librarians to be trained in adopting e‐learning technologies and collaborating with faculties and departments in tutoring the learners.Originality/valueThe study possesses two characteristics that make it different from other studies in the related area. First of all, it provides a theoretical basis for librarians to be actively involved in e‐learning as it listed some responsibilities of the library and librarians in executing e‐learning programmes. Secondly, the paper proposes six laws (Sm2U2L) to govern e‐learning and libraries.
Changing research scenario in Pakistan and demand for research qualified LIS professionals
Authors: Mahmood Khalid , Shafique Farzana 
Published: April 2010

PurposeThe purpose of this paper is to review the changing scenario of research in Pakistan and the status of demand and supply of library and information science (LIS) professionals with research qualifications to fill the leadership positions in Pakistan.Design/methodology/approachGovernment reports and websites were reviewed and telephonic contacts made with LIS faculty and senior librarians.FindingsThe paper finds that research activities are rapidly increasing in Pakistan, while there is a wide gap between demand and supply of LIS professionals with research qualifications.Originality/valueThe researchers have furnished some recommendations for filling the identified gap.
What breaks trust in customer supplier relationship?
Authors: Laeequddin Mohammed , Sardana G.D. 
Published: April 2010

PurposeThe purpose of this paper is to understand what breaks trust in a customer supplier relationship and how to repair it.Design/methodology/approachThe approach takes a single case study to test the established theories on trust. It captures the circumstances and conditions of everyday situation in business and it is a longitudinal study covering three years' experience of two organisations in business.FindingsThe important findings of this case study are that knowledge, level of risk and level of risk tolerance of customers/suppliers are the main causes of trust break down. Though the research on trust focus on partner's characteristics such as benevolence, honesty, reliability, credibility, integrity, contracts, agreements etc., in the context of B2B relationship these perspectives can only help the partners in evaluating the other partner as trust worthy. Once the partners engage in the relationship the orientation will change towards perspectives of rational risk. If the risk level exceeds their bearable limits, trust will break. Trust repair depends on the convincing power of the trustees, and how and why the trustor should bear the uncertainty or risk involved in the relationship.Research limitations/implicationsWith its focus on two business partners this case cannot be generalised to all business settings. However, the in‐depth analysis stimulates further research on how trust may break between partners and how and who (trustor/trustee) should initiate trust repair process.Practical implicationsPracticing managers and research scholars can use this case in trust building process in customer supplier relationship.Originality/valueThe paper presents a case that is original.
Key issues in managing technology transfer projects
Authors: Jagoda Kalinga , Maheshwari Bharat , Lonseth Robert 
Published: April 2010

PurposeThis paper aims to explore and illustrate the technology transfer (TT) experiences of a small to medium‐sized enterprise (SME), Rayton Packaging, using the stage‐gate approach to TT as an inquiry lens.Design/methodology/approachThe approach described in this case conceptualizes TT as a process consisting of a set of stages and decision gates.FindingsA TT project cannot be considered to be effective unless it also leads to profitability and growth for the firm. In today's global business setting, TT should be seen only as a component of business strategy and not in isolation as a technology project.Originality/valueThis paper describes the stage‐gate approach which has been successfully used for managing new product development programs in large firms.