bluuebunny/crossref_metadata_2025_split huggingface dataset:
Antihypertensive Prescribing Patterns for Adolescents With Primary Hypertension
Authors: Yoon Esther Y. , Cohn Lisa , Rocchini Albert , Kershaw David , Freed Gary , Ascione Frank , Clark Sarah 
Published: December 2011

Background:
Hypertension is an increasingly common problem in adolescents yet current medical management of primary hypertension in adolescents has not been well-described.

Methods:
We identified adolescents with primary hypertension by International Classification of Diseases, Ninth Revision codes and looked at prescription patterns chronologically for antihypertensive drug class prescribed and the specialty of prescribing physician. We also examined patient demographics and presence of obesity-related comorbidities.

Results:
During 2003–2008, there were 4296 adolescents with primary hypertension (HTN); 66% were boys; 73% were aged 11 to 14 years; 53% were black, 41% white, and 4% Hispanic; and 48% had obesity-related comorbidity. Twenty-three percent (977) received antihypertensive prescription. White subjects (odds ratio [OR]: 1.61; confidence interval [CI]: 1.39–1.88), older adolescents (≥15 years, OR: 2.11; CI: 1.79–2.48), and those with comorbidity (OR: 1.57; CI: 1.36–1.82) were more likely to receive antihypertensive prescriptions controlling for gender and years of Medicaid eligibility in logistic regression. Angiotensin converting enzyme inhibitors were the most frequently prescribed monotherapy. Nearly two-thirds of adolescents received prescriptions from adult primary care physicians (PCPs) only. More than one-quarter of adolescents who received a prescription received combination therapy, which was most often prescribed by adult PCPs.

Conclusions:
Adult PCPs were the leading prescribers of antihypertensives for adolescents with primary HTN. Race differences exist in physicians’ prescribing of antihypertensives to adolescents with primary HTN. The choice of antihypertensives by physicians of different specialties warrants additional study to understand the underlying rationale for treatment decisions and to determine treatment effectiveness.
Bacterial Lysine Decarboxylase Influences Human Dental Biofilm Lysine Content, Biofilm Accumulation, and Subclinical Gingival Inflammation
Authors: Lohinai Zsolt , Keremi Beata , Szoko Eva , Tabi Tamas , Szabo Csaba , Tulassay Zsolt , Levine Martin 
Published: December 2011

Background: Dental biofilms contain a protein that inhibits mammalian cell growth, possibly lysine decarboxylase from Eikenella corrodens. This enzyme decarboxylates lysine, an essential amino acid for dentally attached cell turnover in gingival sulci. Lysine depletion may stop this turnover, impairing the barrier to bacterial compounds. The aims of this study are to determine biofilm lysine and cadaverine contents before oral hygiene restriction (OHR) and their association with plaque index (PI) and gingival crevicular fluid (GCF) after OHR for 1 week.Methods: Laser‐induced fluorescence after capillary electrophoresis was used to determine lysine and cadaverine contents in dental biofilm, tongue biofilm, and saliva before OHR and in dental biofilm after OHR.Results: Before OHR, lysine and cadaverine contents of dental biofilm were similar and 10‐fold greater than in saliva or tongue biofilm. After 1 week of OHR, the biofilm content of cadaverine increased and that of lysine decreased, consistent with greater biofilm lysine decarboxylase activity. Regression indicated that PI and GCF exudation were positively related to biofilm lysine after OHR, unless biofilm lysine exceeded the minimal blood plasma content, in which case PI was further increased but GCF exudation was reduced.Conclusions: After OHR, lysine decarboxylase activity seems to determine biofilm lysine content and biofilm accumulation. When biofilm lysine exceeds minimal blood plasma content after OHR, less GCF appeared despite more biofilm. Lysine appears important for biofilm accumulation and the epithelial barrier to bacterial proinflammatory agents. Inhibiting lysine decarboxylase may retard the increased GCF exudation required for microbial development and gingivitis.
Adsorption of Enamel Matrix Proteins to a Bovine‐Derived Bone Grafting Material and Its Regulation of Cell Adhesion, Proliferation, and Differentiation
Authors: Miron Richard J. , D. Bosshardt Dieter , Hedbom Erik , Zhang Yufeng , Haenni Beat , Buser Daniel , Sculean Anton 
Published: December 2011

Background: The use of various combinations of enamel matrix derivative (EMD) and grafting materials has been shown to promote periodontal wound healing/regeneration. However, the downstream cellular behavior of periodontal ligament (PDL) cells and osteoblasts has not yet been studied. Furthermore, it is unknown to what extent the bleeding during regenerative surgery may influence the adsorption of exogenous proteins to the surface of bone grafting materials and the subsequent cellular behavior. In the present study, the aim is to test EMD adsorption to the surface of natural bone mineral (NBM) particles in the presence of blood and determine the effect of EMD coating to NBM particles on downstream cellular pathways, such as adhesion, proliferation, and differentiation of primary human osteoblasts and PDL cells.Methods: NBM particles were precoated in various settings with EMD or human blood and analyzed for protein adsorption patterns via fluorescent imaging and high‐resolution immunocytochemistry with an anti‐EMD antibody. Cell attachment and cell proliferation were quantified using fluorescent double‐stranded DNA‐binding dye. Cell differentiation was analyzed using real‐time polymerase chain reaction for genes encoding runt‐related transcription factor 2, alkaline phosphatase (ALP), osteocalcin (OC), and collagen1α1 (COL1A1), and mineralization was assessed using red dye staining.Results: Analysis of cell attachment and cell proliferation revealed significantly higher osteoblast and PDL cell attachment on EMD‐coated surfaces when compared with control and blood‐coated surfaces. EMD also stimulated release of growth factors and cytokines, including bone morphogenetic protein 2 and transforming growth factor β1. Moreover, there were significantly higher mRNA levels of osteoblast differentiation markers, including COL1A1, ALP, and OC, in osteoblasts and PDL cells cultured on EMD‐coated NBM particles.Conclusion: The present results suggest that 1) EMD enhances osteoblast and PDL cell attachment, proliferation, and differentiation on NBM particles, and 2) blood contamination of the grafting material before mixing with EMD may inhibit EMD adsorption.
An Assessment of Microbiological Quality of Some Commercially Packed and Fresh Fruit Juice Available in Dhaka City: A Comparative Study
Authors: Rahman Tasmina , Hasan Sabrina , Noor Rashed 
Published: December 2011

Fruit juices are regarded as the most preferred non-alcoholic beverage worldwide to all age groups. In general, microbial growth in fruit juice is restricted by using preservatives and also through other environmental factors during production. Still, the presence of some indicator organisms in fruit juice is responsible for causing food-borne diseases and even death. So, from public health point of view, it is quite important to know the microbiological quality of the fruit juices available in the market. Primary objective of this study was to assess the microbial quality of fresh and commercially packed available juices collected from different locations of Dhaka city. A total of six fresh juice and nine commercially packed juice samples were collected. Standard culture techniques were followed to assess total viable count (TVC), total staphylococcal count (TSC), total Bacillus count (TBC) and total fungal count (TFC) on different culture media. The TVC varied from the range of 102 to 105 cfu/ml with the highest of 2.4 x 105 cfu/ml. A large number of staphylococci and Bacillus was also found from several samples. Total coliform and fecal coliform was found in six and five (out of fifteen) samples, respectively. Among total coliforms, Klebsiella, Enterobacter along with E. coli were detected. From all the assessment it was determined that the microbial quality of commercially packed juice was fairer than that of fresh juice collected from local market. DOI: http://dx.doi.org/10.3329/sjm.v1i1.9097 Stamford Journal of Microbiology, Vol.1(1), July 2011, p.13-18
Microbiological Quality Assessment of Foods collected from Different Hospitals within Dhaka City
Authors: Rabbi Fazle Alam , Rabbi Fazle , Runun TA , Zaman Khadiza , Rahman M Majibur , Noor Rashed 
Published: December 2011

Various types of cooked food samples were collected from six different hospitals within the city of Dhaka and they were analyzed for the presence (if any) of total aerobic count (TAC), total coliform count (TCC) and total staphylococcal count (TSA) in order to determine the levels of contamination and to relate these findings to the hygiene practice of the food handlers. According to Gulf standard for microbiological criteria for foodstuff, all of the food samples exceeded the acceptable total aerobic count limit of 5 x 105 cfu/g while 4 out of 6 samples exceeded coliform count limit of 1x102 cfu/g. The total coliform counts were found to be the highest in the fish (1.6 x 107 cfu/g) and egg (2.2 x 106 cfu/g) curry samples of hospital 1 and hospital 4, respectively and were the lowest in the fish curry (2 x 103 cfu/g) of hospital 4. Staphylococcus aureus was found in all of the food samples with the highest occurrence (too numerous to count) in Dal and Rice samples from hospitals 3 and 6, respectively. On Xylose Lysine Deoxycholate (XLD) agar, no black centered colony but many colorless colonies were found which primarily indicated the absence of Salmonella spp. in those samples. In order to identify pathogenic microorganisms from food samples, a series of conventional biochemical tests were performed with 23 randomly selected isolates from MacConkey, XLD, MSA agar plates. The isolates were presumptively identified as Escherichia coli, Staphylococcus aureus, Shigella spp. and Pseudomonas spp. etc. The antibiotic susceptibility test was performed with eleven selected isolates using six commonly prescribed antibiotics (ampicillin, tetracyclines, ciprofloxacin, vancomycin, gentamicin and azithromycin). The results showed that six isolates were resistant to vancomycin, two isolates were multidrug resistant and one isolate was intermediately resistant to azithromycin. All the isolates were found to be sensitive to ciprofloxacin, and gentamicin. Based on the data, it can be suggested that adequate hygiene practices are required after cooking the foods and before serving them as they reconsider.DOI: http://dx.doi.org/10.3329/sjm.v1i1.9100 Stamford Journal of Microbiology, Vol.1(1), July 2011, p.31-36
Microbiological Study on Supply Water and Treated Water in Dhaka City
Authors: Acharjee Mrityunjoy , Rahman Farjana , Beauty Sadia Afrin , Feroz Farahnaaz , Rahman M Majibur , Noor Rashed 
Published: December 2011

Water borne diseases are the major cause of morbidity and mortality in developing countries like Bangladesh, where disease outbreaks occur due to unsafe drinking water, inadequate sanitation and poor hygienic practices. The objective of this study was to evaluate the quality of water used for drinking as well as household purposes in Dhaka city, Bangladesh. Eighteen water samples were collected from different rivers and canals. Among those, two samples were treated with chlorine. Physico-chemical parameters (pH, salinity, turbidity, conductivity and dissolved oxygen) were monitored during the time of sample collection using portable meters. For microbiological analysis, water samples were collected in sterile screw capped bottle. All Experiments were carried out within 24 hours after collecting the samples. All the water sources were found to be contaminated with total coliform, faecal coliform, Escherichia coli, Klebsiella spp., Salmonella spp., Shigella spp., Vibrio cholerae, Aeromonas spp. and Fungi except treated water samples. Several biochemical tests were performed for confirmation of suspected organisms. According to these results, huge amount of total coliform and faecal coliform were observed in every sample and these amount were very much similar for other organisms. Treated water samples were found to be microbiologically accepted than untreated water samples. DOI: http://dx.doi.org/10.3329/sjm.v1i1.9132 Stamford Journal of Microbiology, Vol.1(1), July 2011, p.42-45
Mané Rutual en Locmariaquer (Morbihan). Enregistrement de gravures et simulations architecturales dans une tombe à couloir néolithique Mané Rutual (Locmariaquer, Morbihan) / Recording off engravings and architectural simulations in a neolithic passage tomb
Authors: Cassen Serge , Merheb Mouatassem , Lefèbvre Dominique 
Published: December 2011

La tombe à couloir du Mané Rutual est l'une des premières, dès le début du XIXe siècle, à bénéficier de l'attention des savants intéressés par les signes gravés sur orthostates et dalles de couverture. Pourtant, plusieurs gravures inédites seront encore une fois découvertes durant cette campagne de relevés « numériques », soit sur des supports anciennement inventoriés, soit sur de nouvelles stèles (chambre).
Dans le droit fil de l'expérience menée sur le Mané Lud, les formes exactes des stèles seront restituées grâce à des procédés de levés topographiques et de traitement infographique des surfaces (3D). Ces méthodes ont permis de comprendre, entre autres, la dissymétrie de la figure immense du plafond (enlèvement ancien d'une plaque rocheuse qui a soustrait la « boucle » latérale de la figure) ; elles permettront également, un jour prochain nous l'espérons, de répliquer en d'autres lieux des fac-similés de ces représentations, gravures difficiles à reconnaître et dont la destruction insidieuse et sournoise impose l'organisation et la mise en œuvre rapide d'un indispensable et urgent processus de sauvetage.
Défier Hollywood : la diplomatie culturelle et le cinéma à l'ère Brejnev
Authors: Kozovoï Andreï 
Published: December 2011

Résumé Après 1964, la diplomatie culturelle soviétique utilise plus que jamais l’industrie cinématographique pour rivaliser avec « l’ennemi principal » de guerre froide, Hollywood, et ce, dans le monde entier. De la célèbre adaptation par Bondartchouk de Guerre et paix de Tolstoï (1965) à la saga militaire Libération (1971), largement oubliée aujourd’hui, la première partie de l’ère Brejnev est marquée par un effort destiné non seulement à regagner le terrain perdu face aux États-Unis, mais aussi à contrer une vision de l’histoire hostile à la mythologie officielle du parti. Si le bilan de cette offensive apparaît décevant, l’étude des coproductions montre qu’en réalité, il convient de se garder des schémas binaires (efficacité/inefficacité) dans l’étude de la diplomatie culturelle soviétique.
Navigated Total Hip Arthroplasty Using a 3-D Freehand Ultrasound System: Technical Note and Preliminary Results
Authors: Hirschmann Michael T. , Afifi Faik K. , Helfrich Carsten , Wirz Dieter , Schwägli Tobias , Overhoff Heinrich Martin , Moser Walter , Friederich Niklaus F. 
Published: December 2011

Ultrasound-navigated cementless total hip arthroplasty (THA) was performed in 10 consecutive patients with primary osteoarthritis of the hip between August 2008 and October 2009 (M:F, 6:4; median age, 61 years; age range, 30–86 years). The pelvic orientation was defined by preoperative digitization and registration of bony landmarks. Cup inclination and anteversion were documented for each patient intraoperatively (epidigitized vs ultrasound-assessed landmarks). The median difference between the palpated and ultrasound anterior pelvic plane was 8° (range, 4°–18°) for pelvic tilt (rotation around the transversal axis), 1° (range, −3° to 2°) for rotation around the longitudinal axis, and 0.25° (range, −2.0° to 5.0°) for rotation around the sagittal axis. The median difference in cup orientation resulting from pelvic tilt error was 6° (range, 3°–13°) for anteversion and 3° (range, −1° to 5°) for inclination. There were no intra- or postoperative complications. The measured width of soft tissue layer anterior to the pelvic symphysis correlated significantly with the measured difference in cup inclination and anteversion. One centimeter of soft tissue anterior to the symphysis resulted in a median 2° (range, 1.75°–2.3°) difference in pelvic tilt.
Ultrasound-assisted navigation in THA is a promising technology able to eliminate systematic errors in anterior pelvic plane orientation, in contrast to conventionally navigated THA using percutaneous palpation of landmarks or THA without navigational support.
Intraosseous Ganglion With Impending Fracture of the Glenoid
Authors: Tudisco Cosimo , Bisicchia Salvatore 
Published: December 2011

Intraosseous ganglia are benign cystic and often multiloculated lesions located in the subchondral bone. Only 13 cases around the shoulder have been described in the literature. These lesions are often asymptomatic, but, in cases located close to neurovascular structures or articular surfaces, they can be symptomatic, causing pain, neurologic dysfunction, or articular fractures.
This article reports the clinical, radiographic, and pathological findings of a 34-year-old man reporting shoulder pain during heavy working activities. At physical examination, his left shoulder showed complete active and passive range of motion but was painful in external rotation and extension. Tests for the evaluation of the rotator cuff were all negative. The anterior apprehension test provoked pain. The Constant-Murley score was 59 points. Radiographs, computed tomography (CT) scan, and magnetic resonance arthrography showed an elliptical-shaped osteolytic area in the anteroinferior portion of the glenoid extending to the anteroinferior glenoid margin. Leakage of the intra-articular contrast medium showed that the cyst had eroded the articular surface and was about to cause an intra-articular fracture of the glenoid. The patient was operated on with the suspicion of an intraosseous ganglion. The cyst was curetted carefully and packed with autologous bone from the proximal tibia and artificial bone chips. At 1-year follow-up, the patient was completely asymptomatic and reported no pain during his working activities. Physical examination was negative. Radiographs and CT scan showed a cystic lesion in the anteroinferior margin of the glenoid that was partially filled by bone.
Bisphosphonate Fractures as a Cause of Painful Total Hip Arthroplasty
Authors: Curtin Brian M. , Fehring Thomas K. 
Published: December 2011

Osteoporotic fractures pose a significant health concern for postmenopausal women. Bisphosphonate therapy has been shown to decrease the risk of these fractures. The bisphosphonate alendronate was approved by the US Food and Drug Administration for use in the United States in 1995, but questions have recently arisen concerning low-energy subtrochanteric femur fractures sustained by chronic users. Although no definitive association or causality between bisphosphonates and these fractures has been established, numerous cautionary reports exist concerning the duration of use and safety of alendronate in osteoporotic patients.
This article reports 3 occurrences of bisphosphonate-associated atypical femur fractures as an etiology of periprosthetic hip pain in the total hip arthroplasty (THA) patient. These fractures are particularly concerning because these patients are often not advised to protect their weight bearing simply due to a painful THA and may sustain a catastrophic failure if not followed closely. Several theories have been suggested concerning the pathophysiology of atypical low-energy subtrochanteric fractures following bisphosphonate use. Each patient described in this article carried a diagnosis of rheumatoid arthritis and underwent chronic medical therapy; each patient experienced a delay in the diagnosis and onset of therapy due to low suspicion for bisphosphonate-associated fracture. This problem may become more common in the clinical setting; therefore, one must be vigilant and aware of this etiology of periprosthetic hip pain.
Biochemical and Anthropometric Effects of a Weight Loss Dietary Supplement in Healthy Men and Women
Authors: McCarthy Cameron G. , Canale Robert E. , Alleman Rick J. , Reed Jacob P. , Bloomer Richard J. 
Published: December 2011

Background We have recently noted an acute increase in circulating free fatty acids and glycerol, as well as resting metabolic rate, when men and women ingested the dietary supplement OxyELITE Pro™ in a single dose. We have also noted a reduction in appetite when subjects were treated with this supplement for 14 consecutive days. It is possible that such findings may favor body weight and fat loss over time. Therefore, the purpose of the present study was to determine the effects of this dietary supplement on weight loss and associated markers using an eight week intervention. Methods Exercise-trained subjects were randomly assigned in double blind manner to ingest either the dietary supplement (n = 16; aged 22.8 ± 0.7) or a placebo (n = 16; 22.5 ± 0.5) every day for eight weeks. Body weight, body composition, skinfold thickness, serum lipids, and appetite were measured as the primary outcome variables. As measures of supplement safety, a complete blood count and comprehensive metabolic panel were performed, and resting heart rate and blood pressure were measured (pre and post intervention). Results No interactions or main effects were noted for our primary outcome measures ( P > 0.05). However, when comparing pre and post intervention values for the supplement, significant decreases were noted in appetite, body weight, body fat percentage, and skinfold thickness ( P < 0.05), while increases were noted for total and HDL-C, as well as for resting heart rate ( P < 0.05). No changes were noted for placebo from pre to post intervention ( P > 0.05), with the exception of an increase in HDL-C ( P < 0.05). Blood pressure and bloodborne safety variables were not differently impacted by supplement or placebo ( P > 0.05), with the exception of monocytes, for which an interaction effect was noted ( P = 0.04). Conclusion These data indicate that the dietary supplement OxyELITE Pro™ may assist in weight and body fat loss in a sample of exercise-trained men and women. The supplement does not result in any adverse effects pertaining to resting blood pressure or bloodborne markers of safety; however a small increase in resting heart rate is observed.