bluuebunny/crossref_metadata_2025_split huggingface dataset:
Affordances, phenomenology, pragmatism and the myth of the given
Authors: Wilkinson Taraneh , Chemero Anthony 
Published: June 2024

Abstract
This paper addresses a potential contradiction between the two primary philosophical traditions that inform Gibsonian ecological psychology: the phenomenological and pragmatist traditions. These two traditions exhibit potentially contradictory intuitions about the epistemic role of direct perception. This epistemic role of direct perception was famously problematized by Sellars’ critique of the myth of the given (1956; 1997), and we draw on it here to serve as a test case for the Gibsonian synthesis of phenomenology and pragmatism. While ecological psychology’s emphasis on the firstperson perspective of organisms shares in the legacy of the phenomenological tradition, it also tends to assume direct experience as a given, something basic and foundational to knowledge. Pragmatism, on the other hand, is generally suspicious of experience as a foundational given. We argue that Gibson’s successful synthesis of these two traditions is also what makes his theory of affordances less susceptible to the myth of the given than some phenomenological approaches to perception. Namely, on the Gibsonian account of perception is always part of an action-perception cycle that takes place in and through embodied action and therefore no one act of perception functions as an epistemic given
Constitutive expression of bZIP19 with the Zn sensor motif deleted in Arabidopsis leads to Zn-specific accumulation and no visible developmental penalty
Authors: Huizinga Sjors , Persson Daniel P. , Assunção Ana G. L. 
Published: June 2024

Abstract

Aims
The transcription factors bZIP19 and bZIP23 function as central regulators of the Zn deficiency response, and also as sensors of intracellular Zn concentration through their protein Zn-Sensor Motif (ZSM). While under Zn deficiency the target genes of bZIP19/23 are transcriptionally activated, under Zn sufficiency the binding of Zn2+ ions to the ZSM halts gene expression. Mutations, including deletions, in the ZSM affect the activity of bZIP19/23 and leads to a Zn-insensitive and constitutive activation of target gene expression. Here we investigated the effects of such deregulation of the Zn deficiency response on plant growth and Zn accumulation, and evaluate whether this deregulation influences Cd accumulation.

Methods
We analysed Arabidopsis lines constitutively expressing bZIP19 with the ZSM deleted and measured developmental traits and ionomics in soil-grown plants, comparing control and Cd-spiked soils.

Results
Results indicated that deletion of the ZSM, and the consequent deregulation of the Zn deficiency response, does not cause visible penalties in plant growth, development or reproduction. Compared with the wild-type, bZIP19-ZSM deletion increased Zn accumulation in leaves and seeds, and such an increase was mostly limited to Zn. In seeds, the increased Zn content appears distributed evenly throughout the embryo. Exposure of bZIP19-ZSM deletion to a low-level Cd contamination did not cause enhanced Cd accumulation, which is important given that Cd uptake is a concern in crop Zn biofortification. Finally, we verified that the bZIP19-ZSM deletion represents a gain-of-function dominant mutation.

Conclusion
Together, results support that modulation of F-bZIP transcription factor’s activity may be a promising avenue for Zn biofortification in crops.
What are the perspectives of patients with hand and wrist conditions, chronic pain, and patients recovering from stroke on the use of patient and outcome information in everyday care? A Mixed-Methods study
Authors: Arends Grada R. , Loos Nina L. , van Kooij Yara E. , Tabeau Kasia , de Ridder Willemijn A. , Selles Ruud W. , Veltkamp Joris ,   Outcome-Based Healthcare Research Group, Wouters Robbert M. 
Published: June 2024

Abstract
Purpose
To evaluate the patients’ perspectives on the use of patient- and outcome information tools in everyday care and to investigate which characteristics affect general understanding and perceived value of patient- and outcome information.

Methods
This mixed-methods study included surveys and interviews on understanding, experience, decision-support, and perceived value in patients with hand and wrist conditions and chronic pain. We synthesized our quantitative and qualitative findings using a triangulation protocol and identified factors independently associated with general understanding and perceived value of patient- and outcome information using hierarchical logistic regression.

Results
We included 3379 patients. The data triangulation indicated that patients understand the outcome information, they find it valuable, it supports decision-making, and it improves patient-clinician interaction. The following variables were independently associated with better general understanding: having more difficulty with questionnaires (standardized odds ratio 0.34 [95%-CI 031–0.38]), having a finger condition (0.72 [0.57–0.92]), longer follow-up (0.75 [0.61–0.91]), and undergoing surgical treatment (ref: non-surgical treatment, 1.33 [1.11–1.59]). For more general value, these were: having more difficulty with questionnaires (0.40 [0.36–0.44]), having a wrist condition (0.71 [0.54–0.92]), better hand function (1.12 [1.02–1.22]), and requiring help with questionnaires (1.65 [1.33–2.05]).

Conclusion
Patients value the use of patient- and outcome information tools in daily care and find it easy to understand. The factors associated with understanding and value can be targeted to personalized and value-based healthcare. We recommend using outcome information to improve patient independence, empowerment, and involvement in decision-making.
Foundational English literacy development in India: a randomised-control trial using phonics instruction and GraphoLearn
Authors: Bora Deepti , Patel Priyanka , Psyridou Maria , Ruotsalainen Jenni , Richardson Ulla , Torppa Minna 
Published: June 2024

AbstractFoundational literacy is a key lever for achieving higher levels of learning and societal wellbeing. However, with an enrolment of over 250 million children in schools, India is currently challenged by learning deprivation. Growing uptake of English-medium education along with less-than-optimal English literacy instruction practices present an urgent need for improving classroom instruction. Further evidence is required on the efficacy of computer-assisted game-based learning and phonics instruction over the alphabet-spelling method in literacy learning. The current intervention study examined whether classroom phonics instruction combined with GraphoLearn, a computer-assisted reading tool, supports the English phonological awareness and reading skills better than phonics instruction alone. Participants were 6–7 year-old, Grade 2 students (N = 54) attending an English-medium public school in India. All students were non-native English speakers and received phonics instruction in their classroom for 35 min thrice a week. In addition, students were randomly allocated to play either GraphoLearn-Rime (n = 28) or a math control game (n = 26) for 15–20 min every day. Both the GraphoLearn-Rime and the math control group made significant improvement in English literacy skills over the period of intervention and the amount of exposure to phonics classroom instruction predicted gains in phonological awareness skills. The GraphoLearn-Rime group gained more than the math control group in the in-game measures. In the oral-and paper-based measures, both groups showed skill development, but the groups were not significantly different in the gains (d = .04 − .29). Overall, the study indicated the potential in the integrated approach and thus the need for more research on the effects of integrating classroom phonics instruction and GraphoLearn for supporting struggling readers of English.
Space of Challenges (SOC) Framework: Problems, Issues and Dilemmas in Sustainable Housing
Authors: Rosvall Max 
Published: June 2024

AbstractIn pursuit of global sustainable value creation, the conceptual ambiguity inherent in sustainability poses a challenge for goal-seeking problem-solvers. This paper addresses this challenge by introducing a typology for distinguishing among nine types of sustainability challenges that could be faced in systemic intervention. To navigate the complexity and vagueness inherent in sustainability, the Space of Challenges (SOC) is utilized as a tool for second-order systems thinking, grounded in the fundamentals of critical systems thinking. The paper aims to support system thinkers seeking to organise a systemic intervention for improved sustainability performance of systems. The support is developed to contribute to the alignment of sustainability challenges with suitable systems methodologies in multimethodological systemic interventions. A typology is proposed to differentiate sustainability challenges, and then integrated with the Cynefin sense-making framework to categorise challenges as simple, complicated or complex. The Space of Challenges framework is then applied to a case of sustainable housing in East Africa exploring alternative binders in block-based building, to highlight the differences among the nine types of proposed sustainability challenges.
Association of vitamin D and bisphenol A levels with cardiovascular risk in an elderly Italian population: results from the InCHIANTI study
Authors: Brandi Maria Luisa , Marini Francesca , Parri Simone , Bandinelli Stefania , Iantomasi Teresa , Giusti Francesca , Talluri Eleonora , Sini Giovanna , Nannipieri Fabrizio , Battaglia Santina , Tripepi Giovanni , Egan Colin Gerard , Ferrucci Luigi 
Published: June 2024

AbstractFew studies have evaluated the association between circulating levels of 25-hydroxyvitamin D (25(OH)D), 1,25-dihydroxyvitamin D (1,25(OH)2D), and the endocrine disruptor bisphenol A (BPA), with risk of cardiovascular (CV) disease in elderly individuals. This was a cross-sectional study in a subgroup of elderly people from the InCHIANTI Biobank in Italy. We examined the association between circulating serum vitamin D metabolites, 1,25(OH)2D, 25(OH)D, and the endocrine disrupting agent BPA, with an arbitrary CV risk score and the European Society of Cardiology-based 10-year CV risk (SCORE2/SCORE2-OP) using univariate and multiple regression. In 299 individuals, blood samples were tested for serum values of 25(OH)D, 1,25(OH)2D and urinary BPA levels. One hundred eighty individuals (60.2%) were deficient (< 20 ng/ml) in 25(OH)D. Levels of 25(OH)D and 1,25(OH)2D were negatively correlated with CV risk score (p < 0.0001 for both) as well as SCORE2/SCORE2-OP (p < 0.0001 for both) while BPA levels were positively correlated with both CV risk scores (p < 0.0001 for both). In a logistic regression model, male gender (odds ratio; OR: 2.1, 95% CI:1.1–3.8, p = 0.022), obesity (OR:2.8, 95% CI:1.2–6.5, p = 0.016) and BPA levels ≥ 110 ng/dl (OR:20.9, 95% CI:9.4–46.8, p < 0.0001) were associated with deficient levels of 25(OH)D. 1,25(OH)2D levels < 41 ng/dl and 25(OH)D levels < 20 ng/ml were associated with CV risk score ≥ 3 (OR: 4.16, 95% CI: 2.32–7.4, p < 0.0001 and OR: 1.86, 95% CI: 1.02–3.39, p = 0.044) respectively and 1,25(OH)2D levels < 41 ng/dl were associated with SCORE2/SCORE2-OP of ≥ 20% (OR:2.98, 95% CI: 1.7–5.2, p = 0.0001). In this cross-sectional analysis, BPA exposure was associated with significantly reduced levels of vitamin D that in turn were significantly associated with increased CV risk.
Preparation of surgical meshes using self-regulating technology based on reaction-diffusion processes
Authors: Polyák Péter , Vadász Katalin Fodorné , Tátraaljai Dóra , Puskas Judit E. 
Published: June 2024

Abstract
While reaction-diffusion processes are utilized in multiple scientific fields, these phenomena have seen limited practical application in the polymer industry. Although self-regulating processes driven by parallel reaction and diffusion can lead to patterned structures, most polymeric products with repeating subunits are still prepared by methods that require complex and expensive instrumentation. A notable, high-added-value example is surgical mesh, which is often manufactured by weaving or knitting. In our present work, we demonstrate how the polymer and the biomedical industry can benefit from the pattern-forming capabilities of reaction-diffusion. We would like to propose a self-regulating method that facilitates the creation of surgical meshes from biocompatible polymers. Since the control of the process assumes a thorough understanding of the underlying phenomena, the theoretical background, as well as a mathematical model that can accurately describe the empirical data, is also introduced and explained. Our method offers the benefits of conventional techniques while introducing additional advantages not attainable with them. Most importantly, the method proposed in this paper enables the rapid creation of meshes with an average pore size that can be adjusted easily and tailored to fit the intended area of application.

Graphical abstract
Familien mit psychosozialen Belastungen identifizieren: psychometrische Eigenschaften und Nutzerakzeptanz eines neuen Screeninginstruments (PFAM-Screen) für die pädiatrische Praxis
Authors: Georg A. K. , Berning A. , Vidalón Blachowiak T. , Wiehmann J. , Al-Ameery-Brosche I. , Dierolf J. , Krämer J. , Kalmar J. , Baumann I. , Heger J. , Taubner S. 
Published: June 2024

Zusammenfassung
Hintergrund
Die Identifikation und Weitervermittlung psychosozial belasteter Familien stellt einen zentralen Aspekt der pädiatrischen Präventivmedizin dar. Ein kurzer Screeningbogen, der psychosoziale Belastungsfaktoren in der gesamten Spanne des Kindes- und Jugendalters erfasst, verspricht eine bestehende Lücke in der Versorgung von Familien zu schließen. Ziel der Studie war die psychometrische Prüfung des Screeningbogens (PFAM-Screen) zur Identifikation psychosozialer Belastungen in Familien und die Untersuchung dessen Anwendbarkeit in der Praxis.

Methode
Untersucht wurden N = 61 Familien in drei Ambulanzen des Universitätsklinikums Heidelberg und des Zentrums für Psychologische Psychotherapie Heidelberg. Die Anwendbarkeit des PFAM-Screens wurde bei N = 16 niedergelassenen Pädiater:innen untersucht.

Ergebnisse
Im Ergebnis konnte eine einfaktorielle Faktorenstruktur bestätigt werden. Die Interrater-Reliabilität ist gegeben (κ = 0,72). Explorative Analysen zeigten nicht signifikante positive Korrelationen zwischen dem PFAM-Screen und Fragebögen zur Erfassung von kindlichen Verhaltensauffälligkeiten (r(SFS) = 0,27; p = 0,145; r(CBCL) = 0,28; p = 0,117). Es stellte sich eine mehrheitlich positive Bewertung der Anwendbarkeit des Bogens in der pädiatrischen Praxis dar.

Diskussion und Schlussfolgerung
Der PFAM-Screen ist ein handhabbarer und reliabler Screeningbogen zur Früherkennung erhöhter psychosozialer Belastung im gesamten Altersbereich der Kindheit und Jugend, dessen Integration in die pädiatrische Präventivmedizin wünschenswert erscheint. Die Studie legt die Grundlage für zukünftige Forschung in größeren Stichproben zur prädiktiven Validität, Reliabilität und zum Nutzen hinsichtlich erfolgreicher Weitervermittlung.
Simultaneous bilateral total hip arthroplasty—a survey of Irish orthopaedic surgeons’ practice
Authors: Doyle Tom R. , Davey Martin S. , Toale James P. , O’Driscoll Conor , Murphy Colin G. 
Published: June 2024

Abstract
Background
Bilateral total hip arthroplasty may be performed simultaneously (SIMTHA) or in two staged operations.

Aim
To assess attitudes towards and utilization of SIMTHA in Irish orthopaedic practice, and to assess patient and surgeon factors which are associated with the management of bilateral hip arthritis.

Methods
A 16-question electronic survey (Google Forms) was distributed via email to consultant Irish orthopaedic surgeons who perform total hip arthroplasty, followed by a reminder 1 month later. A p value < 0.05 was considered significant.

Results
There were 53 responses from arthroplasty surgeons, with 28% reporting they never perform SIMTHA, 26% have performed ≤ 5 SIMTHA, and 46% do ≥ 1 SIMTHA per year. Amongst the 15 surgeons who do not do SIMTHA, 60% reported a preference for staged arthroplasty, 20% felt it was not feasible in their institution, and a third reported a lack of experience with SIMTHA. There was a significant association between not performing SIMTHA and years of consultant experience (p = 0.002). There were no institutional guidelines on eligibility criteria for SIMTHA. The most common time interval for staged bilateral arthroplasty was 6–12 weeks (60%). Overall, 56% of surgeons felt SIMTHA is underutilised in the Irish healthcare system; this was associated with greater SIMTHA volume (p = 0.023).

Conclusion
Half of the Irish arthroplasty surgeons report SIMTHA is a regular aspect of their practice. Performing SIMTHA is associated with greater arthroplasty volume, more recent consultant appointments, and a perception that the operation is underutilised.
Source apportionment of PM2.5 using DN-PMF in three megacities in South Korea
Authors: Cheong Yeonseung , Kim Taeyeon , Ryu Jiwon , Ryoo Ilhan , Park Jieun , Jeon Kwon-ho , Yi Seung-Muk , Hopke Philip K. 
Published: June 2024

AbstractPM2.5 pollution is problematic in megacities on the western coast in South Korea (Seoul, Incheon, and Gwangju). As these megacities are located downwind of China, their air quality is easily affected by local and long-range transport sources. PM2.5 samples collected in Seoul (n = 222), Incheon (n = 221), and Gwangju (n = 224) from September 2020 to March 2022, were chemically characterized. Dispersion normalized positive matrix factorization was applied to these PM2.5 speciated data to provide source apportionments. Nine common sources (including secondary nitrate, secondary sulfate, biomass burning, mobile, and waste incinerator) were identified at all sites. The conditional bivariate probability function helped to identify each site’s local sources. Joint potential source contribution function analysis identified northeast China and Inner Mongolia as potential source areas of long-range transport pollutants affecting all sites. Forced lifestyle changes due to the pandemic such as limited gatherings while increased recreational activities may have caused different patterns on the biomass burning source. The constraints on old vehicles during the policy implementation periods likely reduced the mobile source contributions in cities that adopted the policy. Secondary nitrate accounted for 40% of the PM2.5 mass at all sites, implying a significant impact from NOX sources. While the current policy focuses primarily on controlling primary emission sources, it should include secondary sources as well which may include precursor emissions control. Healthier air quality would be achieved if the policy effects are not limited to local, but also to foreign sources in regions upwind of Korea by intergovernmental collaboration.
Enhanced Survival of 22–25 Week Preterm Infants After Proactive Care Implementation: A Comparative Analysis of Two Time Periods
Authors: Kim Sae Yun , Shin Jeongmin , Oh Moon Yeon , Youn Young-Ah 
Published: June 2024

Abstract
Objectives
To investigate the impact of proactive perinatal care on periviable preterm infants before and after its implementation.

Methods
This retrospective cohort study was conducted over a period of 10 y, from 2013 to 2019, referred to as Phase I, and from 2020 to 2022, referred to as Phase II. A total of 162 eligible infants born between 220/7 and 256/7 wk of gestation were included in this analysis.

Results
A total of 125 infants were born in phase I, and 37 infants in phase II received proactive care with minimal handling. The mortality decreased from 54.4% to 24.3% (P = 0.001). The composite outcomes of severe brain injury or death, sepsis or death and necrotizing enterocolitis or death were also improved with proactive care. Gestational age [adjusted odds ratio (aOR) 0.900; 95% confidence interval (CI), 0.836–0.970], air leak syndrome (aOR 4.958; 95% CI, 1.681–14.624), massive pulmonary hemorrhage (aOR 4.944; 95% CI, 2.055–11.893), and birth in phase II (aOR 0.324; 95% CI, 0.115–0.912) were independently associated with mortality.

Conclusions
The implementation of proactive care with minimal handling resulted in an increased survival rate and a reduction in the combined morbidities between the two time periods. The provision of proactive perinatal care with minimal handling is crucial for improving both the survival rates and clinical outcomes of these vulnerable infants.
Gut microbiota composition in recurrent acute otitis media: a cross-sectional observational study
Authors: Florjan Andrej , Rupnik Maja , Mahnic Aleksander 
Published: June 2024

AbstractRecurrent acute otitis media (rAOM) poses a significant challenge in children aged 1 to 6 years, characterized by frequent and treatment-resistant ear infections. While existing studies predominantly focus on alterations in the nasopharyngeal microbiome associated with rAOM, our research explores the understudied association with the gut microbiome. In this cross-sectional observational prospective study, we enrolled 35 children aged 1 to 6 years during the 2021/2022 cold season. The test group comprised children with rAOM (n = 16), and the control group consisted of generally healthy children (n = 19). Samples (stool and nasopharyngeal swabs) were collected in late spring to ensure an antibiotic-free period. Detailed metadata was gathered through a questionnaire examining factors potentially influencing microbiota. Microbiota composition was assessed through amplicon sequencing of the V3–V4 region of the 16S rRNA gene. Our findings revealed limited alterations in gut microbiota composition among children with rAOM compared to healthy controls. Six bacterial taxa (Veillonella, Lachnospiraceae, Ruminococcaceae, Lachnospiraceae, Bacteroides and Blautia) were differentially represented with weak statistical significance. However, several bacterial taxa displayed correlations with multiple consecutive infections, with Turicibacter showing the most significant association. Additionally, day care centre attendance emerged as a potent gut microbiota modifier, independent of rAOM. Although our study identified limited differences in gut microbiota composition between children with rAOM and healthy controls, the observed correlations between the number of infections and specific bacterial taxa suggest a potential link between rAOM and the gut microbiota, warranting further investigation.