bluuebunny/crossref_metadata_2025_split huggingface dataset:
Stability control of single-wheel failure in four-wheel independent drive electric vehicles
Authors: Xu Tao , Liu Tao , Zhao Peng , Qiang Guiyan , Zheng Zheng , Liu Yiqun 
Published: May 2024

Abstract
The integration of the motor and transmission mechanism into the wheels of a four-wheel independent drive electric vehicle with hub motors increases the frequency of failures, especially torque output failures, which seriously affect vehicle stability and jeopardize driving safety. This paper focuses on the perspective of single-wheel torque output failure and studies the vehicle stability control strategy. Firstly, based on the constructed simulation dynamics model, a slip controller is designed to obtain the direct lateral moment. Then, based on the control allocation principle, upper-level lateral moment allocation rules are designed, and torque allocation rules under single-wheel torque output failure are formulated. Finally, simulation experiments are conducted under different operating conditions. The simulation results show that this control strategy can effectively control vehicle stability under single-wheel failure conditions and ensure safe driving.
Research on the vehicle lane-changing decision-making system in complex traffic environments
Authors: Lu Xiaochun , Wei Xikai , Zhang Yongjie 
Published: May 2024

Abstract
In order to ensure the safety of vehicles changing lanes, there should be a certain degree of interaction and dynamics between vehicles on the way. In this paper, the problems of non-interactive road information and imprecise path planning are investigated. Through the research of the road condition decision-making system, autonomous lane-changing assistance system and intelligent traffic system, vehicle wireless networking technology, vehicle-road cooperation technology, and lane-changing decision-making and planning technology are used to increase the frequency of information interaction between vehicles and the external environment in order to realize information interaction between vehicles and collaborative driving. In this paper, simulation experiments of vehicle lane-changing are carried out by using MATLAB Simulink and compared with other research models. The results show that the lane change planning data based on the road condition decision system is more accurate, which leads to fast lane change driving in complex traffic scenarios.
Searching for WIMPs with TREX-DM: achievements and challenges
Authors: Castel J.F. , Cebrián S. , Dafni T. , Díez-Ibáñez D. , Ezquerro A. , Galán J. , García J.A. , Irastorza I.G. , Jiménez M. , Luzón G. , Margalejo C. , de Mira A. , Mirallas H. , Obis L. , Ortiz de Solórzano A. , Pérez O. , Ruz J. , Vogel J. 
Published: May 2024

Abstract
The TREX-DM detector, a low background chamber with microbulk Micromegas readout, was commissioned in the Canfranc Underground Laboratory (LSC) in 2018. Since then, data taking campaigns have been carried out with argon and neon mixtures, at different pressures from 1 to 4 bar. By achieving a low energy threshold of 1 keV
ee
and a background level of 80 counts keV-1 kg-1 day-1 in the region from 1 to 7 keV
ee
, the experiment demonstrates its potential to search for low-mass WIMPs. Two of the most important challenges currently faced are the reduction of both, background level and energy threshold. With respect to the energy threshold, recently a new readout plane is being developed, based on the combination of Micromegas and GEM technologies, aiming to have a pre-amplification stage that would permit very low energy thresholds, close to the single-electron ionization energy. With respect to the background reduction, apart from studies to identify and minimize contamination population, a high sensitivity alpha detector is being developed in order to allow a proper material selection for the TREX-DM detector components. Both challenges, together with the optimization of the gas mixture used as target for the WIMP detection, will take TREX-DM to explore regions of WIMP's mass below 1 GeV c
-2.
Design of a very low power 12 bits, 40 MS/s ADC based on a time-interleaved SAR architecture
Authors: Bontems W. , Dzahini D. 
Published: May 2024

Abstract
The paper describes a new figure of merit reachable in terms of very low power dissipation for a 12 bit, 40 MS/s Analog to Digital Converter in a 65 nm CMOS process with 1 V power supply. A differential time interleaved successive approximations register architecture is used. Each individual ADC channel is optimized with regard to power consumption hence interleaving 28 ADC channels in an analog memory like method, the total power consumption is only 280 μW including all the reference voltage drivers, the clock management and the digital sections. The total layout area of this converter is 0.87 mm2.
Design of multi-channel electronic prototype for 101Sn energy level lifetime measurement
Authors: Wang Z. , Yan J. , An Y. , Liang G. , Zhou X. , Wang C. , Pu T. , She Q. , Fang F. , Qiang Y. , Guo S. , Qian Y. , Kong J. 
Published: May 2024

Abstract
In this study, a 32-channel front-end data acquisition unit
(DAQU) with high temporal resolution and count rate was developed at
the Heavy Ion Research Facility in Lanzhou (HIRFL), China, to
measure the lifetime of 101Sn on the Spectrometer for Heavy
Atoms and Nuclear Structure. The DAQU data analysis module uses a
field programmable gate array (FPGA) to implement and time stamp
extraction through an FPGA-based tapped delay line (TDL)
time-to-digital converter. The energy measurements were implemented
using a trapezoidal algorithm and a sliding baseline averaging
method. The DAQU was tested and calibrated using a pulse generator
and cosmic rays. The results show that the system had a dead time of
less than 500 ns, a dynamic range of “0” to “500” mV, and an
energy resolution of better than 4.8‰ (full width
at the half-maximum, FWHM). In addition, the single-channel temporal
resolution under multi-channel settings surpasses 111.2 ps (FWHM),
satisfying the experiment's requirements for the electronics
system.
Exploiting finite geometries for better quantum advantages in Mermin-like games
Authors: Kelleher Colm , Holweck Frédéric , Lévay Péter 
Published: May 2024

Abstract
Quantum games embody non-intuitive consequences of quantum phenomena, such as entanglement and contextuality. The Mermin-Peres game is a simple example, demonstrating how two players can utilise shared quantum information to win a no—communication game with certainty, where classical players cannot. In this paper we look at the geometric structure behind such classical strategies, and borrow ideas from the geometry of symplectic polar spaces to maximise this quantum advantage. We introduce a new game called the Eloily game with a quantum–classical success gap of

0.2

6
―

, larger than that of the Mermin-Peres and doily games. We simulate this game in the IBM Quantum Experience and obtain a success rate of 1, beating the classical bound of

0.7

3
―

demonstrating the efficiency of the quantum strategy.
Exact time-evolving scattering states in open quantum-dot systems with an interaction: discovery of time-evolving resonant states
Authors: Nishino Akinori , Hatano Naomichi 
Published: May 2024

Abstract
We study exact time-evolving many-electron states of an open double quantum-dot system with an interdot Coulomb interaction. A systematic construction of the time-evolving states for arbitrary initial conditions is proposed. For any initial states of one- and two-electron plane waves on the electrical leads, we obtain exact solutions of the time-evolving scattering states, which converge to known stationary scattering eigenstates in the long-time limit. For any initial states of localized electrons on the quantum dots, we find exact time-evolving states of a new type, which we refer to as time-evolving resonant states. In contrast to stationary resonant states, whose wave functions spatially diverge and not normalizable, the time-evolving resonant states are normalizable since their wave functions are restricted to a finite space interval due to causality. The exact time-evolving resonant states enable us to calculate the time-dependence of the survival probability of electrons on the quantum dots for the system with the linearized dispersions. It decays exponentially in time on one side of an exponential point of resonance energies while, on the other side, it oscillates during the decay as a result of the interference of the two resonance energies.
Multisensory Perception
Authors: Doyon Maxime 
Published: May 2024

Abstract
One of the most debated questions in recent scholarship concerns the proper way of characterizing the phenomenology of multisensory experiences. While some believe that the phenomenal character of multisensory integration is reducible to the co-conscious sum of modality-specific features, this chapter refutes this thesis and shows how a vast array of bodily cues and sensations contribute to the experiential make-up of our conscious lives. Building on this insight, it is argued that the phenomenology of multisensory experience includes various forms of bodily self-experiences and often contains felt possibilities of action and behaviours. While spelling out the details of this claim, the chapter outlines an account of multimodal perception and sensory interaction that shows that all forms of perceptual experiences depend on the interplay of two or more senses. At the same time, it specifies the intrinsic relation between normativity and perception by demonstrating the impact of multisensory integration on agency.
State Responsibility and International Liability
Authors: Bhat B. Sandeepa 
Published: May 2024

Abstract
The Outer Space Treaty 1967 stands as a classic example of an earlier treaty, recognising the distinction between State responsibility and international liability with two separate provisions. While norms on State responsibility under the Outer Space Treaty were not further elaborated on with a separate treaty, the space liability norms were supplemented by the Liability Convention 1972. Unfortunately, the real implications of State responsibility and international liability norms under the space treaties remain unclear due to vagueness in the wording of provisions and consequential varied interpretations. It is a grim fact that not a single successful case has been fought under the Liability Convention since its entry into force five decades ago. Hence, it is pertinent to understand the existing regime of State responsibility and international liability under the United Nations space treaties to discover the present concerns with a view to addressing them effectively.
Meaning Bodies
Authors: Marchesi Ilaria 
Published: May 2024

Abstract
The chapter addresses the question of what it means for a woman to be a sign; that is, her double nature as always already a natural/material as well as a cultural/semiotic object. Martial’s women are (i.e., they are made to be) their bodies, bodies that (are made to) bear value. The body of texts analyzed here is extracted from Book 11, a unit in the collection which display’s Martial’s keen interest in somatology. In the selected epigrams the semiotic double bind of women is presented in its purest, most basic, and most essential form: it is a double-bind which extends to, and is rooted in, their bodies. By studying them as material and cultural tokens, at once physically existing and culturally meaning, Martial presents women as caught in the irreducible paradox of all signs. They are the primary example of the semiotic tension affecting his culture.
Architecture and functions of stomatal cell walls in eudicots and grasses
Authors: Jaafar Leila , Anderson Charles T 
Published: May 2024

Abstract

Background
Like all plant cells, the guard cells of stomatal complexes are encased in cell walls that are composed of diverse, interacting networks of polysaccharide polymers. The properties of these cell walls underpin the dynamic deformations that occur in guard cells as they expand and contract to drive the opening and closing of the stomatal pore, the regulation of which is crucial for photosynthesis and water transport in plants.

Scope
Our understanding of how cell wall mechanics are influenced by the nanoscale assembly of cell wall polymers in guard cell walls, how this architecture changes over stomatal development, maturation and ageing and how the cell walls of stomatal guard cells might be tuned to optimize stomatal responses to dynamic environmental stimuli is still in its infancy.

Conclusion
In this review, we discuss advances in our ability to probe experimentally and to model the structure and dynamics of guard cell walls quantitatively across a range of plant species, highlighting new ideas and exciting opportunities for further research into these actively moving plant cells.
O01 Mapping the cellular and molecular dynamics of mouse and human hair follicles reveals mechanisms of hair growth
Authors: Annusver Karl , Fernandez David , Pereira Diana , Nicolas Jean-François , Kasper Maria , Sequeira Inês 
Published: May 2024

Abstract

Introduction and aims
Tissue homeostasis in continuously renewing organs, such as the skin, rely on orchestrated cellular and molecular dynamics. The hair follicle (HF) is characterized by distinct keratinocytes organized in transcriptionally and functionally distinct concentric HF layers. The anagen progenitor cells (also called germinative layer cells) are located juxtaposed to the dermal papilla and give rise to each of the differentiated layers. Despite this well-known high level of organization and cell-lineage separation, it is still unclear how the germinative layer cells coordinate hair growth and commit to specific lineages.

Methods
Here, we employed single-cell RNA sequencing, single-molecule mRNA fluorescence in situ hybridization and in vivo lineage tracing to show how the matrix progenitor cells commit and contribute to the HF lineages depending on their position. Furthermore, we developed a four-dimensional live imaging system of the human HF to construct a global map of single-cell dynamics.

Results
We show that the HF progenitors dynamically relocate in a conveyor-belt-like movement, switch their lineage fate and gradually restrict their potential. This spatiotemporal cell choreography is characterized by a gradual change of expression from Lgr5 in the lower proximal cup, through Dcn, Id3 and Msx1 in the central part, to distal Lef1 expression where the medulla lineage starts. Detailed in situ mRNA staining and mouse clonal lineage tracing show the transcriptional changes and gradual lineage restriction of matrix progenitors in the spatial context. Combining human HF imaging with fluid dynamics theories, we uncovered a spiral-like downward movement of outer root sheath cells, feeding the germinative layer stem cells, and revealed a pulling force induced by the outer root sheath cells as a critical driver for hair growth.

Conclusions
Taken together, our study uncovered how HF progenitor cells progress in a conveyor-belt-like manner through several transcriptional states and discovered new cellular and molecular mechanisms regulating hair formation.
O10 Tuneable Caf1 protein polymers as an innovative and scalable solution for regenerative wound care
Authors: Nie Yuanjinze , Waller Helen , Peter Daniel , Reynolds Nick , Lakey Jeremy 
Published: May 2024

Abstract

Introduction and aims
Wound healing is a complex process essential for tissue restoration, where the extracellular matrix (ECM) plays a crucial role by providing structural and biochemical support to cells. Laminin 332, a key ECM component, is a promising target for protein-based therapeutics in view of its pathogenic role in junctional epidermolysis bullosa (JEB). Bioengineered capsular antigen F1 protein (Caf1) has emerged as a potential candidate molecule. We have developed the technology to enable bacteria to produce Caf1 polymers with multiple tailored bioactive motifs. Additionally, the unique properties of Caf1 minimize the potential for a host immune response. In this study, we engineered Caf1 proteins to express specific synthetic basement membrane components related to laminin 332 with the aim of restoring ECM equilibrium and achieving effective wound healing.

Methods
To evaluate Caf1 construct effects on human epidermal keratinocytes (HEKs) (CCD 1106) and human dermal fibroblasts (HDFs), scratch assays were performed under different treatment with Caf constructs. The Incucyte® ZOOM system (Sartorius AG, Göttingen, Germany) automated scratch wound and Live-Cell Analysis System screened constructs enhancing wound healing, capturing images every 2 h. Analysis involved quantifying the area under the curve of wound confluence (%) over 72 h to assess wound closure.

Results
The migration of HDFs was enhanced by 10.4% ± 0.95% (P &lt; 0.05 Anova, n = 9 independent experiments) when there was interaction with Caf1-CTB4 (PMQKMRGDVFSP). The migration of CCDs was enhanced by 12.7% ± 1.03% when interacting with Caf1-J3 (KNSFMALYLSKGR) and by 14.4% ± 1.11% when interacting with Caf1-J4 (TALIRATYGEYSTGYI) (P &lt; 0.05 Anova; n = 3 independent experiments). Combining Caf1-J3 and Caf1-J4 synergistically boosts CCD migration by 19.1% ± 1.42% (P &lt; 0.05 Anova; n = 3 independent experiments), yielding better Results compared with individual treatments.

Conclusions
Caf1 exhibits promise as a platform for motif delivery, and the incorporation of cell migration motifs into Caf1 holds the potential to enhance wound healing.
O11 Investigating the genetic basis of the influence of adiposity on psoriasis
Authors: Ramessur Ravi , Saklatvala Jake , Mahil Satveer , Barker Jonathan , Loset Mari , Dand Nick , Simpson Michael , Smith Catherine 
Published: May 2024

Abstract

Introduction and aims
Obesity is a chronic inflammatory state that is highly prevalent in people with psoriasis. There is evidence to suggest that increasing levels of adiposity promotes the risk of psoriasis development and worsens disease severity. The degree to which adiposity influences psoriasis varies between individuals, and it is also unclear which key genetic factors underpin this variation. Identifying this could be mechanistically informative in uncovering immunological pathways connecting adiposity and psoriasis. This project explores the hypothesis that the influence of adiposity on psoriasis has a genetic basis.

Methods
Firstly, we examined the comparative strength of association between a range of measures of adiposity and psoriasis in a population-based study (UK Biobank, n = 336 806). Secondly, we performed a genome-wide by environment interaction study (GWEIS) meta-analysis examining the interaction between key measures of adiposity and psoriasis susceptibility in two large population-based studies [UK Biobank and HUNT (n = 164 753)]. Thirdly, in view of this association between human leucocyte antigen (HLA)-C*06:02 and higher adiposity levels in psoriasis, we wanted to explore whether biological differences existed between HLA-stratified subgroups. To explore this, we performed HLA-C*06:02-stratified Mendelian randomization to establish whether a difference in causal effect of adiposity on psoriasis existed between subgroups.

Results
We found that measures of central obesity (including impedance and dual-energy x-ray absorptiometry/magnetic resonance imaging measures) were most strongly associated with both psoriasis risk and severity. A sexual dimorphism was observed, with a stronger effect in men compared with women. Through GWEIS meta-analysis, we found a significant interaction between HLA-C*06:02-status and waist circumference on psoriasis risk (P = 3.69e−08). No significant difference in causal effect of body mass index or waist circumference on psoriasis risk were found in HLA-C*06:02-stratified subgroups.

Conclusions
These findings underscore the significance of central adiposity in influencing psoriasis risk. This study also emphasizes both the value and limitations of HLA-C*06:02 as a potential biomarker for distinguishing metabolically-driven psoriasis.
O12 Macrophages enhance angiogenesis in an induced pluripotent stem cell-derived skin organoid model
Authors: Foster April Rose , Admane Chloe , Adao Diana , Torabi Fereshteh , Gopee Nusayhah Hudaa , Olabi Bayanne , Winheim Elena , Rowe Victoria , Le Phuong Ahn , Serdy Sara , Kim Jin , Deakin CiCi , Lee Jiyoon , Li Tong , Koehler Karl , Gambardella Laure , Haniffa Muzlifah 
Published: May 2024

Abstract

Introduction and aims
Hair-bearing skin organoids (SkOs) are a complex three-dimensional (3D) model that faithfully recapitulates human skin as a multicellular organ with appendage structures. The development of such models provides unique potential for investigating human skin development and translational dermatology. Although this model answers many demands of an investigative tool, one obvious limitation is the absence of immune cells in SkOs. Our aim is to generate coculture systems of SkOs with macrophages to investigate how macrophages influence skin development.

Methods
Our group, and others, generated single-cell (sc)RNA-Seq and spatial transcriptomic datasets to thoroughly characterize human skin cell populations across the human lifespan. We used these datasets to compare the dynamic tempo of induced pluripotent stem cell (iPSC)-derived SkO (n = 84) differentiation with human prenatal (n = 15) and adult skin. For functional assays, we generated 2D angiogenesis coculture assays with macrophages and endothelial cells (n = 3) and 3D coculture of SkOs with macrophages (n = 3). Macrophages, endothelial cells and SkOs were all derived from the same iPSC line following established protocols. SkO vasculature was analysed after immunowholemount staining of CD31+ endothelial cells.

Results
Analysis of scRNA-Seq data highlighted a paucity in endothelial cell heterogeneity in SkOs compared with prenatal skin. We hypothesized that this could be explained by the absence of immune cells, as spatial transcriptomics microenvironment analysis of prenatal skin demonstrated that endothelial cells collocate with macrophages. With this in mind, we generated functional assays to investigate interactions of macrophages and endothelial cells in skin development. The 2D and 3D assays revealed that presence of macrophages significantly increased endothelial cell sprouting and network formation.

Conclusions
Our findings suggest a vital role of macrophages in skin morphogenesis, specifically in relation to the guidance of tip cells during angiogenesis. In addition, we present the SkO as an excellent complex model for investigating skin development, cell–cell interactions, and disease modelling for translational research in regenerative medicine and beyond.