bluuebunny/crossref_metadata_2025_split huggingface dataset:
High glucose condition aggravates inflammatory response induced by Porphyromonas gingivalis in THP-1 macrophages via autophagy inhibition
Authors: Kwon Jin-Ju , Song Yuri , Chung Jin , Shin Sang-Hun 
Published: June 2024

Abstract

Background Porphyromonase gingivalis (P. gingivalis) is a type of the bacteria that cause periodontitis, which is highly correlated with systemic diseases such as diabetes. However, the impact of hyperglycaemia on periodontitis is unclear. In the present study, we investigated the effects of high glucose levels on the response to P. gingivalis infection.Results The expression of P. gingivalis-induced interleukin-1β (IL-1β) and inflammasomes increased with increasing glucose concentration. High glucose conditions suppressed P. gingivalis–induced autophagy in human acute monocytic leukaemia cell line (THP-1) macrophages. Zingerone increased autophagy and alleviated P. gingivalis-induced inflammatory response in THP-1 macrophages under high glucose conditions. In addition, alveolar bone loss due to P. gingivalis infection was significantly higher in diabetic mice than in wild-type mice. P. gingivalis-induced inflammation in bone marrow-derived macrophages of diabetic mice was increased; however, it was decreased by zingerone treatment.Conclusions High-glucose conditions aggravated the inflammatory response to P. gingivalis infection through the suppression of autophagy, suggesting that autophagy induction could potentially be used to treat periodontitis in diabetes.
Nimbolide as a natural fungicide against Black Mold disease of Allium cepa: A molecular docking and simulation-based study
Authors: Dangwal Pranshu , Juyal Saransh , Bhatt Arun , Pathak Rajesh Kumar , Baunthiyal Mamta , Ojha Ravindra 
Published: June 2024

Abstract

Black mold disease provoked by Aspergillus niger is one of the major postharvest diseases in Allium cepa. In the present study, efforts have been made to model the polygalacturonase protein of Aspergillus niger that is involved in disease progression as a promising molecular target for the identification of novel fungicides through computational approach. We used I-TASSER to determine the 3D structure of the target protein and docked it with naturally occurring phytoalexins which included nimbolide, nimbolin, Azadiradione, Quercetin and Azadirone. The result of present study revealed that nimbolide has the greatest affinity towards polygalacturonase as compared to other phytoalexins which binds the protein at amino acid residues Gln205, Gln261, Tyr262 with four hydrogen bonds and − 8.0 kcal/mol binding energy. Further, molecular dynamics simulation of protein and docked nimbolide-polyglacturonase complex was carried out to validate the stability of the system at the atomic level. Based on the study, this may lead to inhibition of pathogenic protein. Thus, it is of interest to consider the molecule for further validation at lab and field conditions for ensuring food and nutritional security.
Model for Estimation of Ultimate Strengthof Connections Made With Gfrp Bars in Wooden Structures
Authors: Penteado Lucas Dellosso , Christoforo André Luis 
Published: June 2024

Abstract

The combination of wood with current technologies allows the use of this material in large structures, both in the idealization of modern projects and in the development of structural projects. Large structures require structural elements with large transversal extensions generating connections between the elements. Therefore, connections have become an important and common element when wood is used as a structural element. The aim of article analyzed the behavior of a wooden structure connection numerically when replacing traditional metallic connectors with connectors made from Glass Fiber Reinforced Polymer (GFRP) bars. A numerical simulation was carried out, with the purpose of calibrating a numerical model based on the results obtained in connection tests, using the ABAQUS software. After a parametric study varying the following characteristics of the connections: (a) Diameter of the GFRP pins, (b) Number of pins, (c) Geometric characteristics of the connection and (d) Wood species. The parametric study results in a multiple variable regression model to estimate the ultimate strength in connections, which presents a Correlation Coefficient (R²) of 75.64%. The proposed model was compared with the accuracy of the Johansen model and it was obtained that the Johansen model overestimates the rupture force values by up to 56% when compared with the values found by the proposed model. This situation is justified because the proposed model by Johansen overestimates the values of ultimate force in favor of safety.
Surgical challenges in performing thyroidectomy on huge multinodular goiters in limited resource settings. Case Series, ideal management protocols, Review of literature and pictorial presentation
Authors: Shabhay Ahmed Ali , Shabhay Zarina Ali , Mwami Amri Salim , Ngwira Jonathan Joseph , Kiguru Shabani Ally , Massaga Fabian Anaclet , Katema Paul Simon , Ndyamkama Domician Sospeter 
Published: June 2024

Abstract

Thyroidectomy is a safe procedure when performed by competent well-trained surgeon in ideal settings. However not all centers have settings that adhere to recommended standard preoperative, intraoperative, and postoperative well laid guidelines. Surgeons in such settings must improvise ingenious methods to comply to recommended guidelines. Patients in resource limited settings present late with huge benign or malignant multinodular goiters with limited preoperative investigative modalities due to financial constraints. These settings create logistical challenges for the attending surgeons in such settings. Thyroidectomy also carries a high legal ramification potential due to its high complication potential index from its anatomical proximity of potential lethal or life changing complications by iatrogenic injury to adjacent structures such as Recurrent Laryngeal Nerve, parathyroid glands, or the large caliber blood vessels. It is the authors intention to highlight these logistical challenges and not recommend or advocate the practice in such settings to be adopted as the standard of care.
Connecting the Local Vertical Data in South America to the IHRF
Authors: Guimarães Gabriel do Nascimento , de Matos Ana Cristina Oliveira Cancoro , Blitzkow Denizar 
Published: June 2024

Abstract

Since 2015, the scientific community has been working on unifying the global vertical datum, following the resolution for the definition and realization of an International Height Reference System. One of the main goals of the task is to determine the vertical offset between the local vertical datum and the global one. This paper aims to estimate the vertical offset in seven countries (Argentina, Brazil, Chile, Colombia, Ecuador, Venezuela, and Uruguay) in South America. For this purpose, geoid (and quasi-geoid) models were computed based on the Geodetic Boundary Value Problem Solution. The technique of removing and restoring the gravity field’s long wavelengths was applied. Terrestrial gravity data and satellite gravity anomalies (in the ocean) were combined with a global geopotential model and a digital terrain model to estimate the geopotential values and compute geoid undulations. GNSS/leveling data were used to infer the geoid (quasi-geoid) models and four global geopotential models. Regarding the vertical offset, GNSS/leveling data and the geoid undulations were used in the computation. A parametric model was used to minimize random and systematic errors in the calculation process. The resultsshowed that the vertical offset varies from 0.293 m (Talcahuano tide gauge - Chile) to 1.689 m (Santana tide gauge - Brazil).
Removal of river water turbidity and total dissolved solids using natural coagulants derived from banana peel and Moringa stenopetala seed
Authors: Lemma Mehiretu , Kalsido Adane Woldemedhin , Wamolo Wotee Mohammed 
Published: June 2024

ABSTRACT

In this study, natural coagulants obtained from banana peel and Moringa stenopetala seed were applied to remove total dissolved solids (TDS) and turbidity from river water. Central composite design (CCD) method was applied for the operating conditions of pH (3–10), coagulant dosage (0.3–1 g/L), stirring speed (30–90 rpm), and settling time (20–60 min). The optimum conditions obtained from the numerical optimization for pH, coagulant dosage, stirring speed, and settling time were 8.52, 1.000 g/L, 33.58 rpm, and 37.92 min, respectively, with a desirability value of 0.883 when banana peel powder was used as a natural coagulant. Under those optimum conditions, the experimental results for banana peel showed 81.32 and 93.09%, removal efficiency for TDS and turbidity, respectively. Similarly, the optimum conditions obtained from numerical optimization for pH, coagulant dosage, stirring speed, and settling time were 9.99, 0.999 g/L, 30.0 rpm, and 39.96 min, respectively, with a desirability value of 0.963. Under these optimum conditions for M. stenopetala seed powder, the experimental results showed 83.64 and 95.13%, removal efficiency for TDS and turbidity, respectively. Overall, M. stenopetala seed powder shows a higher potential for TDS and turbidity removal efficiency than banana peel powder.
The application of satellite sensors, current state of utilization, and sources of remote sensing dataset in hydrology for water resource management
Authors: Abegeja Daniel 
Published: June 2024

ABSTRACT
Hydrologists rely heavily on satellite sensors because they provide useful information for tracking, evaluating, managing water resources, aiding provision of safe drinking water, help preventing waterborne diseases, and address the challenges posed by climate change. Water conservation and the collection of hydrologic data have made remote sensing (RS) an invaluable tool. As a result, there are fewer hydrologic stations globally in terms of space because of various topography landforms, human limitations, and financial limits. A thorough examination of the RS satellite products' hydrological applications is essential to finding a solution to this issue. By doing this, academicians, researchers, and conservationists in various professions can better understand the products and obtain the data needed for conservation. This paper primarily focuses on the following two objectives: 1). To synthesize the scientific information on satellite remote sensing application for hydrology, and 2). To explain the RS dataset sources for hydrologic parameters. Extensive literature search from reputable journal publishers. This review article synthesized vital sources of information for academicians, researchers, and government agencies involved in hydrology and water resources management. It is recommended that RS can be used as a data source for scarce, sparsely gauged, and inaccessible regions.
Study on river channel rainwater and flood resources utilization
Authors: Zhou Yu , Zhang Lili , Zhang Yaowen , Yao Yunsheng , Dai Yiming , Wang Qixin 
Published: June 2024

ABSTRACT
In arid regions, the optimal utilization of river channels to collect rainwater resources can effectively alleviate the problem of water scarcity. This paper employs visual MODFLOW software to simulate the infiltration volume of rainwater under different schemes, with the objective of identifying the optimal infiltration volume. The results indicate that the infiltration volume of rainwater is 0.6, 79.7, 36.5, 62, and 10,000 m3 under different design schemes. COMSOL software is employed to simulate the infiltration situation of rainwater under different schemes, and the scheme with the most favourable infiltration effect is identified. The simulation results indicate that scenarios 2, 4, and 5 demonstrate superior early-stage infiltration performance. Ultimately, the optimal infiltration scheme is selected by integrating the infiltration volume, infiltration effect, construction, economic, and ecological factors to achieve the objective of enhancing rainwater harvesting and utilization. This study offers effective and reasonable measures for addressing the challenge of water resources management in arid regions. It provides suitable reference schemes for river channel rainwater storage projects and offers innovative approaches to rainwater resource utilization, thereby contributing to the alleviation of water scarcity in arid areas.
Effects of membrane content, feed phase, and stripping phase for palladium solution extraction by using a polymer inclusion membrane
Authors: Keskin Başak , Teber Oğuz Orhun , Zeytuncu Bihter , Koyuncu Ismail 
Published: June 2024

ABSTRACT

Palladium is now frequently utilized in fuel cells, electroplating, electronics, and catalysis. Due to their rarity and high cost, precious metal recovery has taken on a significant role. The extraction method frequently utilized in polymer inclusion membranes (PIMs) is both efficient and simple since it has been demonstrated that precious metal adsorption on the membrane significantly controls the mechanism of chemical adsorption. In this study, polyvinyl chloride (PVC) as a polymer, A336 as a plasticizer, and trioctylamine (TOA) as a carrier were used to produce a PIM by evaporation. After the production of PIMs, palladium extract was studied. The stripping phase, palladium concentration in the feed phase, and components of the membrane were changed to determine the optimum condition with better extraction ability. When 0.5 M of HCl was used, higher kinetic parameter results and higher than 85% extraction efficiency were achieved compared to other concen- trations. When the EDX results were examined, 3.3% palladium was retained on the membrane surface. When the palladium concentration was selected at 2.5 ppm, higher kinetic parameters were observed, and the extraction efficiency was over 90%. The best membrane was the PIM containing 40% PVC–40% A336–20% TOA.
The current epizootic and epidemiological situation of coxiellosis in the territories of the Southern, North Caucasian Federal Districts, Donetsk, Lugansk People's Republics, Zaporizhia and Kherson regions
Authors: Sokirkina E. N. , Noskov A. K. , Pichurina N. L. , Tsay A. V. , Simakova D. I. , Kovalev Ye. V. 
Published: June 2024

Objective: to characterize the dynamics and intensity of the incidence of Q fever for the period from 2015 to 2022, to determine the risk areas for human infection in the Southern and North Caucasian Federal districts and in the new subjects of the Russian Federation.Materials and methods: for epidemiological analysis, materials from analytical reviews "The epidemiological situation of natural focal infectious diseases in the Southern and North Caucasus Federal Districts" and state reports "On the state of sanitary and epidemiological welfare of the population" for 2015-2022, reporting data from the Rospotrebnadzor Department for the Rostov region, «Center for Hygiene and Epidemiology in Russia Rostov region» and the Departments of Rospotrebnadzor for the DPR and LPR. From 2022–2023 PCR study was conducted for the presence of Coxiella burnetii DNA in samples of ixodic mites and small mammals in the Rostov region and in 2023 – in the DPR, LPR, Zaporizhia and Kherson regions.Results: the analysis of the territorial distribution of cases of Q fever in the Astrakhan region and Stavropol Territory revealed a cluster of the most disadvantaged areas. An analysis of the conditions of infection of patients with Ku fever in the Rostov region has established that the most likely transmission factors are environmental objects in private farms. The circulation of C. burnetii in natural biotopes of the Rostov region, DNR and LNR regions.Conclusions: the epidemic process of Ku fever is mainly local, limited in the context of municipal districts of Astrakhan and Rostov regions, Stavropol Territory. The sporadic incidence of Ku fever does not reflect its actual level. There is no convincing evidence indicating the leading role of farm animals as a primary link in the formation of the epizootic process of Q fever in anthropurgical foci.
Working condition and health status of employees of the aviation enterprise
Authors: Sabitova M. M. , Shulaev A. V. , Berkheeva Z. M. , Garipova R. V. , Sabitov A. Z. 
Published: June 2024

Objective: a hygienic assessment of working conditions and an analysis of the morbidity of aircraft workers.Materials and methods: the study was carried out on the basis of data from the Office of the Federal Service for Supervision of Consumer Rights Protection and Human Well-Being in the Republic of Tatarstan (Tatarstan) and the Center for Occupational Pathology Scientific and Clinical Center for Preventive Medicine of the Institute of Fundamental Medicine and Biology of the Kazan (Volga Region) Federal University.Results: hygienic monitoring of the working conditions of employees of the aviation plant showed a combined effect of harmful factors of the production environment and the labor process, corresponding to classes 3.1–3.2 in a number of professions. Among the diseases identified in employees of the enterprise, diseases of the eye and its accessory apparatus, circulatory organs and hearing predominate. According to the results of the medical examination, 6.4% of the subjects were found to have a suspicion of occupational chronic bilateral sensorineural hearing loss.Conclusions: research results indicate that there is a risk of developing occupational pathology as a result of exposure to physical factors. The employer was given recommendations to improve working conditions and preserve the health of workers.
Comparative effectiveness of different methods of prescribing rosuvastatin and ezetimibe in combination with PCSK9 inhibitors
Authors: Kuznetsov A. A. , Mal G. S. , Saraev I. A. 
Published: June 2024

Objective: comparative evaluation of the effectiveness of combined lipid-lowering therapy with rosuvastatin and ezetimibe in fixed and separate combinations with PCSK9 inhibitors in patients with very high cardiovascular risk.Materials and methods: 65 study participants were divided into 2 groups depending on the method of combined lipid-lowering therapy and were observed for 5 months on 6 visits. The effectiveness of the hypolipidemic response in each of the studied groups was evaluated.Results: in the group with separate administration of lipid-lowering drugs, the target values of LDL cholesterol reached 50% of patients, the level of LDL cholesterol during 5 months of treatment decreased by 38.22% from 2.25 [1.82; 2.47] mmol/l to 1.39 [1.21; 1.59] mmol/l (p <0.001). In the group with a fixed combination of rosuvastatin and ezetimibe, 61.29% of the study participants reached the target ranges of LDL cholesterol, the concentration of LDL cholesterol decreased by 47.46% from 2.36 [1.92; 2.57] mmol/l to 1.24 [1.18; 1.56] mmol/l (p <0.001). Logistic regression analysis showed a significant association of females with a higher risk of not reaching the target ranges of LDL cholesterol (χ2<0.001; OR 0.13 95 % CI 0.04-0.39; p<0.001).Conclusion: the use of a fixed combination of rosuvastatin and ezetimibe in combination with PCSK9 inhibitors in patients with very high cardiovascular risk makes it possible to reduce the concentration of LDL cholesterol by 9.24% more intensively relative to the drug regimen with separate administration of drugs.
Web-Based Forums for People Experiencing Substance Use or Gambling Disorders: Scoping Review
Authors: Peart Annette , Horn Freya , Petukhova Rachel , Barnett Anthony , Lubman Dan I 
Published: June 2024

Background
For people experiencing substance use or gambling disorders, web-based peer-supported forums are a space where they can share their experiences, gather around a collective goal, and find mutual support. Web-based peer support can help to overcome barriers to attending face-to-face meetings by enabling people experiencing addiction to seek support beyond their physical location and with the benefit of anonymity if desired. Understanding who participates in web-based peer-supported forums (and how), and the principles underpinning forums, can also assist those interested in designing or implementing similar platforms.

Objective
This study aims to review the literature on how people experiencing substance use or gambling disorders, and their family, friends, and supporters, use and participate in web-based peer-supported forums. Specifically, we asked the following research questions: (1) What are the characteristics of people who use web-based peer-supported substance use or gambling-focused forums? (2) How do people participate in web-based peer-supported forums? (3) What are the key principles reportedly underpinning the web-based peer-supported forums? (4) What are the reported outcomes of web-based peer-supported forums?

Methods
Inclusion criteria for our scoping review were peer-reviewed primary studies reporting on web-based addiction forums for adults and available in English. A primary search of 10 databases occurred in June 2021, with 2 subsequent citation searches of included studies in September 2022 and February 2024.

Results
Of the 14 included studies, the majority of web-based peer-supported forums reported were aimed specifically for, or largely used by, people experiencing alcohol problems. Results from the 9 studies that did report demographic data suggest forum users were typically women, aged between 40 years and early 50 years. Participation in web-based peer-supported forums was reported quantitatively and qualitatively. The forums reportedly were underpinned by a range of key principles, mostly mutual help approaches and recovery identity formation. Only 3 included studies reported on outcomes for forum users.

Conclusions
Web-based peer-supported forums are used by people experiencing addiction in a number of ways, to share information and experiences, and give and receive support. Seeking web-based support offers an alternative approach to traditional face-to-face support options, and may reduce some barriers to engaging in peer support.