bluuebunny/crossref_metadata_2025_split huggingface dataset:
Radicals of Free and Zinc(II)‐Coordinated α‐Azophenols
Authors: Kochem Amélie , Orio Maylis , Philouze Christian , Jamet Hélène , du Moulinet d'Hardemare Amaury , Thomas Fabrice 
Published: November 2010

AbstractThe tridentate 2‐tert‐butyl‐4‐methoxy‐6‐(quinolin‐8‐ylazo)phenol ligand HL has been synthesized and structurally characterized. Its redox activity has been investigated by electrochemical measurements and DFT calculations. Oxidation of HL (irreversible process) affords primarily a hydrogen‐bonded phenoxyl radical, whereas its reduction affords an iminosemiquinonate radical species. The reaction of two equivalents of HL with Zn(OAc)2 affords the zinc complex Zn(L)2, which has been structurally characterized. Its oxidation is easier than that of HL and is reversible. The EPR spectrum of [Zn(L)(L·)]+ shows an unresolved (S = 1/2) signal at g = 2.005, while [Zn(L·)]2+ exhibits spin triplet resonances (|D| = 0.0118 cm–1 and E/D = 0). The extra delocalization of spin density on the azo group contributes to a lowering of the D value relative to those of Schiff base derivatives. The temperature dependence of the EPR signal and DFT calculations reveal an excited state for the spin triplet and a weak exchange coupling constant J = –2.73 cm–1.
Fluorescent Polylactides with Rhenium(bisimine) Cores for Tumour Diagnostics (Eur. J. Inorg. Chem. 32/2010)
Authors: Brückmann Nadine E. , Kögel Susanne , Hamacher Alexandra , Kassack Matthias U. , Kunz Peter C. 
Published: November 2010

AbstractThe cover picture shows the structure of a fluorescent polymer consisting of a ligand‐functionalised polylactide coordinated to Re(CO)3(phen). This polymer can passively target cancer tissue and transport the fluorescent dye to the cancer cell membranes, where it can be detected by fluorescence microscopy, which enables early detection of cancer. The resulting fluorescence in the membranes of A2780 cells can be seen in the background. Details are discussed in the article by P. C. Kunz et al. on p. 5063 ff.
A Novel N(3),N(4)‐Bridging Coordination Mode of 1‐R‐Tetrazole‐5‐thiolates – Synthesis, X‐ray Diffraction, Magnetic Properties and Quantum‐Chemical Study of a Macrocyclic Dinickel Complex Coligated by 1‐Methyltetrazole‐5‐thiolate (Eur. J. Inorg. Chem. 34/2010)
Authors: Voitekhovich Sergei V. , Syre Ronny , Lach Jochen , Matulis Vadim E. , Gaponik Pavel N. , Ivashkevich Oleg A. , Kersting Berthold 
Published: November 2010

AbstractThe cover picture shows a schematic representation of the procedure used for the determination of the magnetic properties of the macrocyclic dinickel complex [Ni2L(μ‐SCN4Me)]BPh4·2MeCN. On the left, the complex is depicted in the form of its two nickel atoms, their first coordination sphere and the 1‐methyltetrazole‐5‐thiolate coligand as obtained from the crystal structure determination. The found N(3),N(4)‐bridging coordination mode is hitherto unknown for 1‐R‐tetrazole‐5‐thiolates. In addition, theoretical calculations were carried out in order to study the coordination features of the complex. Details are discussed in the article by S. V. Voitekhovich, B. Kersting et al. on p. 5387 f. The authors gratefully acknowledge the DAAD (Leonard‐Euler program) and the Erasmus Mundus program “Advanced Spectroscopy in Chemistry”. Supported by the Deutsche Forschungsgemeinschaft within the Graduate School BuildMoNa.
Unexpected Heterocyclic Products from Cycloaddition Reactions of Nonsymmetrical Allenyl Aldoketazines with Substituted Alkynes
Authors: Galeta Juraj , Man Stanislav , Bouillon Jean‐Philippe , Potáček Milan 
Published: November 2010

AbstractThermally initiated cycloaddition reactions of nonsymmetrical allenyl azines 1 with alkynes or other dipolarophiles usually lead to compounds with three fused, five‐membered heterocyclic rings. With alkynes with pronounced “push–pull” systems, however, the reaction ends with the formation of substituted pyrrolidino[1,2‐b]pyrazoles 4 and, in the case of azines with trifluoromethyl substitution, ring opening leads to the isolation of compounds 9. Reaction mechanisms for these transformations are proposed. The molecular structures of the new heterocycles 4 and 9 were confirmed by X‐ray crystal structure analysis.
Efficient Syntheses and Complexation Studies of Diacetylene‐Containing Macrocyclic Polyethers
Authors: Feng Yahui , Li Jingning , Jiang Lasheng , Gao Zhihong , Huang Weicong , Jiang Fei , Luo Nianhua , Han Shujuan , Zeng Ronghua , Yang Dingqiao 
Published: November 2010

AbstractA series of novel macrocyclic polyethers, phenylene–diacetylene‐containing macrocycles was synthesized in high yields by employing copper(II)‐mediated Eglinton coupling as the key macrocyclization (80–92 %). As an analogue of the bisphenylene crown ether hosts, the binding behavior of these new macrocycles was investigated by 1H NMR spectroscopy, mass spectrometry (ESI), and X‐ray crystallography. The results obtained indicate that macrocycles with tetraethylene glycol chains (3c–e) bind a paraquat guest to form [2]pseudorotaxane‐like complexes in solution and in the solid state, whereas macrocycles with triethylene glycol chains (i.e., 3f–h) bind a paraquat guest to form [3]pseudorotaxane‐like complexes, which implies that macrocycles 3f–h may be able to complex to (mono)pyridinium cations in a [2]pseudorotaxane‐like fashion in solution.
Seismic performance of wood‐frame houses in south‐western British Columbia
Authors: Goda Katsuichiro , Atkinson Gail M. 
Published: November 2010

AbstractThe seismic performance of conventional wood‐frame structures in south‐western British Columbia is analytically investigated through incremental dynamic analysis by utilizing available UBC‐SAWS models, which were calibrated based on experimental test results. To define an adequate target response spectrum that is consistent with information from national seismic hazard maps, record selection/scaling based on the conditional mean spectrum (CMS) is implemented. Furthermore, to reflect complex seismic hazard contributions from different earthquake sources (i.e. crustal events, interface events, and inslab events), we construct CMS for three earthquake types, and use them to select and scale an adequate set of ground motion records for the seismic performance evaluation. We focus on the impacts of adopting different record selection criteria and of using different shear‐wall types (Houses 1–4; in terms of seismic resistance, House 1>House 2>House 3>House 4) on the nonlinear structural response. The results indicate that the record selection procedures have significant influence on the probabilistic relationship between spectral acceleration at the fundamental vibration period and maximum inter‐story drift ratio, highlighting the importance of taking into account response spectral shapes in selecting and scaling ground motion records. Subjected to ground motions corresponding to the return period of 2500 years, House 1 is expected to experience very limited extent of damage; Houses 2 and 3 may be disturbed by minor damage; whereas House 4 may suffer from major damage occasionally. Finally, we develop statistical models of the maximum inter‐story drift ratio conditioned on a seismic intensity level for wood‐frame houses, which is useful for seismic vulnerability assessment. Copyright © 2010 John Wiley & Sons, Ltd.
A fundamental dual‐zone continuum theory for dynamic soil–structure interaction
Authors: Pak Ronald Y. S. , Ashlock Jeramy C. 
Published: November 2010

AbstractA continuum theory for an improved characterization of dynamic soil–structure interaction in the framework of three‐dimensional elastodynamics is presented. Effective in demonstrating the importance of integrating free‐field and near‐field effects under general soil and foundation conditions, a compact two‐zone delineation of the soil medium is proposed as a quintessential mechanics perspective for this class of problems. Sufficient to deliver a practical resolution of some perennial analytical and experimental conflicts, a fundamental formulation commensurate to a gradated unification of the homogenization approach and any sole free‐field inhomogeneous representation is developed and implemented computationally. Specialized to the problem of a rigid circular footing on sand, a nominal set of dynamic contact stress distributions and related impedance functions by the dual‐zone theory is included for theoretical and engineering evaluation. Through its comparison with benchmark analytical solutions and relevant physical measurements, the usage of the underlying conceptual platform as an advanced yet practical foundation for general dynamic soil–structure interaction is illustrated. Copyright © 2010 John Wiley & Sons, Ltd.
Germline polymorphisms in genes involved in the CD44 signaling pathway are associated with clinical outcome in localized gastric adenocarcinoma
Authors: Winder Thomas , Ning Yan , Yang Dongyun , Zhang Wu , Power Derek G , Bohanes Pierre , Gerger Armin , Wilson Peter M. , Lurje Georg , Tang Laura H , Shah Manish , Lenz Heinz‐Josef 
Published: November 2010

AbstractThe cluster of differentiation 44 (CD44) signaling pathway is crucial in cancer‐cell growth, invasion, proliferation and metastasis. CD44 is a transmembrane receptor for hyaluronan and osteopontin, and has recently attracted attention as a gastric cancer stem cell marker. Previous studies showed that polymorphisms in the CD44 gene can influence both human cancer survival and determine cellular response to cytotoxic chemotherapeutics. In addition, CD44 protein overexpression has been associated with poor prognosis in gastric adenocarcinoma (GA). We tested the hypothesis whether polymorphisms involved in the CD44 pathway will predict clinical outcome in patients with localized GA. Either blood or formalin‐fixed paraffin‐embedded (FFPE) tissues were obtained from 137 patients with localized GA at University of Southern California and Memorial Sloan‐Kettering Cancer Center medical facilities. DNA was isolated and polymorphisms within the CD44 pathway were determined by PCR‐RFLP technique. In univariate analysis CD44 rs187116 and CD44 rs7116432 were significantly associated with time to tumor recurrence (TTR) and overall survival (OS). After adjusting for covariates, patients harboring at least one G allele of CD44 rs187116 remained significantly associated with TTR (adjusted p = 0.009) and OS (adjusted p = 0.045). Further, patients harboring CD44 T‐A haplotype were at the lowest risk of developing tumor recurrence (HR: 0.255; 95% CI: 0.11–0.591; adjusted p = 0.001) and death (HR 0.198; 95% CI: 0.07–0.563; adjusted p = 0.002). These results provide the first evidence that CD44 polymorphisms predict clinical outcome in patients with localized GA. This may help to identify localized GA patients at high risk for tumor recurrence.
Markers of fibrosis and epithelial to mesenchymal transition demonstrate field cancerization in histologically normal tissue adjacent to breast tumors
Authors: Trujillo Kristina A. , Heaphy Christopher M. , Mai Minh , Vargas Keith M. , Jones Anna C. , Vo Phung , Butler Kimberly S. , Joste Nancy E. , Bisoffi Marco , Griffith Jeffrey K 
Published: November 2010

AbstractPrevious studies have shown that a field of genetically altered but histologically normal tissue extends 1 cm or more from the margins of human breast tumors. The extent, composition and biological significance of this field are only partially understood, but the molecular alterations in affected cells could provide mechanisms for limitless replicative capacity, genomic instability and a microenvironment that supports tumor initiation and progression. We demonstrate by microarray, qRT‐PCR and immunohistochemistry a signature of differential gene expression that discriminates between patient‐matched, tumor‐adjacent histologically normal breast tissues located 1 cm and 5 cm from the margins of breast adenocarcinomas (TAHN‐1 and TAHN‐5, respectively). The signature includes genes involved in extracellular matrix remodeling, wound healing, fibrosis and epithelial to mesenchymal transition (EMT). Myofibroblasts, which are mediators of wound healing and fibrosis, and intra‐lobular fibroblasts expressing MMP2, SPARC, TGF‐β3, which are inducers of EMT, were both prevalent in TAHN‐1 tissues, sparse in TAHN‐5 tissues, and absent in normal tissues from reduction mammoplasty. Accordingly, EMT markers S100A4 and vimentin were elevated in both luminal and myoepithelial cells, and EMT markers α‐smooth muscle actin and SNAIL were elevated in luminal epithelial cells of TAHN‐1 tissues. These results identify cellular processes that are differentially activated between TAHN‐1 and TAHN‐5 breast tissues, implicate myofibroblasts as likely mediators of these processes, provide evidence that EMT is occurring in histologically normal tissues within the affected field and identify candidate biomarkers to investigate whether or how field cancerization contributes to the development of primary or recurrent breast tumors.
Metabolic syndrome and mammographic density: The Study of Women's Health Across the Nation
Authors: Conroy Shannon M. , Butler Lesley M. , Harvey Danielle , Gold Ellen B. , Sternfeld Barbara , Greendale Gail A. , Habel Laurel A. 
Published: November 2010

AbstractThe metabolic syndrome (MetS) is associated with an increase in breast cancer risk. In our study, we evaluated whether the MetS was associated with an increase in percent mammographic density (MD), a breast cancer risk factor. We used linear regression and mixed models to examine the cross‐sectional and longitudinal associations of the MetS and components of the MetS to percent MD in 790 premenopausal and early perimenopausal women enrolled in the Study of Women's Health Across the Nation (SWAN). In cross‐sectional analyses adjusted for body mass index (BMI), modest inverse associations were observed between percent MD and the MetS [β = −2.5, standard error (SE) = 1.9, p = 0.19], abdominal adiposity (β = −4.8, SE = 1.9, p = 0.01) and raised glucose (β = −3.7, SE = 2.4, p = 0.12). In longitudinal models adjusted for covariates including age and BMI, abdominal adiposity (β = 0.34, SE = 0.17, p = 0.05) was significantly positively associated with slower annual decline in percent MD with time. In conclusion, our results do not support the hypothesis that the MetS increases breast cancer risk via a mechanism reflected by an increase in percent MD.
The calcium-sensing receptor mediates bone turnover induced by dietary calcium and parathyroid hormone in neonates
Authors: Shu Lei , Ji Ji , Zhu Qi , Cao Guofan , Karaplis Andrew , Pollak Martin R , Brown Edward , Goltzman David , Miao Dengshun 
Published: November 2010

Abstract
We have investigated, in neonates, whether the calcium-sensing receptor (CaR) mediates the effects of dietary calcium on bone turnover and/or modulates parathyroid hormone (PTH)–induced bone turnover. Wild-type (WT) pups and pups with targeted deletion of the Pth (Pth–/–) gene or of both Pth and CaR (Pth–/–CaR–/–) genes were nursed by dams on a normal or high-calcium diet. Pups nursed by dams on a normal diet received daily injections of vehicle or of PTH(1–34) (80 µg/kg) for 2 weeks starting from 1 week of age. In pups receiving vehicle and fed by dams on a normal diet, trabecular bone volume, osteoblast number, type 1 collagen–positive area, and mineral apposition rate, as well as the expression of bone-formation-related genes, all were reduced significantly in Pth–/– pups compared with WT pups and were decreased even more dramatically in Pth–/–CaR–/– pups. These parameters were increased in WT and Pth–/– pups but not in Pth–/–CaR–/– pups fed by dams on a high-calcium diet compared with pups fed by dams on a normal diet. These parameters also were increased in WT, Pth–/–, and Pth–/–CaR–/– pups following exogenous PTH treatment; however, the percentage increase was less in Pth–/–CaR–/– pups than in WT and Pth–/– pups. In vehicle-treated pups fed by dams on either the normal or high-calcium diet and in PTH-treated pups fed by dams on a normal diet, the number and surfaces of osteoclasts and the ratio of RANKL/OPG were reduced significantly in Pth–/– pups and less significantly in Pth–/–CaR–/– pups compared with WT pups. These parameters were further reduced significantly in WT and Pth–/– pups from dams fed a high-calcium diet but did not decrease significantly in similarly treated Pth–/–CaR–/– pups, and they increased significantly in PTH-treated pups compared with vehicle-treated, genotype-matched pups fed by dams on the normal diet. These results indicate that in neonates, the CaR mediates alterations in bone turnover in response to changes in dietary calcium and modulates PTH-stimulated bone turnover. © 2011 American Society for Bone and Mineral Research.
Involvement of calcitonin and its receptor in the control of calcium-regulating genes and calcium homeostasis in zebrafish (Danio rerio)
Authors: Lafont Anne-Gaëlle , Wang Yi-Fang , Chen Gen-Der , Liao Bo-Kai , Tseng Yung-Che , Huang Chang-Jen , Hwang Pung-Pung 
Published: November 2010

Abstract
Calcitonin (CT) is one of the hormones involved in vertebrate calcium regulation. It has been proposed to act as a hypocalcemic factor, but the regulatory pathways remain to be clarified. We investigated the CT/calcitonin gene–related peptide (CGRP) family in zebrafish and its potential involvement in calcium homeostasis. We identified the presence of four receptors: CTR, CRLR1, CRLR2, and CRLR3. From the phylogenetic analysis, together with the effect observed after CT and CGRP overexpression, we concluded that CTR appears to be a CT receptor and CRLR1 a CGRP receptor. The distribution of these two receptors shows a major presence in the central nervous system and in tissues involved in ionoregulation. Zebrafish embryos kept in high-Ca2+-concentration medium showed upregulation of CT and CTR expression and downregulation of the epithelial calcium channel (ECaC). Embryos injected with CT morpholino (CALC MO) incubated in high-Ca2+ medium, showed downregulation of CTR together with upregulation on ECaC mRNA expression. In contrast, overexpression of CT cRNA induced the downregulation of ECaC mRNA synthesis, concomitant with the downregulation in the calcium content after 30 hours postfertilization. At 4 days postfertilization, CT cRNA injection induced upregulation of hypercalcemic factors, with subsequent increase in the calcium content. These results suggest that CT acts as a hypocalcemic factor in calcium regulation, probably through inhibition of ECaC synthesis. © 2011 American Society for Bone and Mineral Research.
Impact of maturational status on the ability of osteoblasts to enhance the hematopoietic function of stem and progenitor cells
Authors: Cheng Ying-Hua , Chitteti Brahmananda R , Streicher Drew A , Morgan Joseph A , Rodriguez-Rodriguez Sonia , Carlesso Nadia , Srour Edward F , Kacena Melissa A 
Published: November 2010

Abstract
Osteoblasts (OBs) exert a prominent regulatory effect on hematopoietic stem cells (HSCs). We evaluated the difference in hematopoietic expansion and function in response to co-culture with OBs at various stages of development. Murine calvarial OBs were seeded directly (fresh) or cultured for 1, 2, or 3 weeks prior to seeding with 1000 Lin-Sca1 + cKit+ (LSK) cells for 1 week. Significant increases in the following hematopoietic parameters were detected when comparing co-cultures of fresh OBs to co-cultures containing OBs cultured for 1, 2, or 3 weeks: total hematopoietic cell number (up to a 3.4-fold increase), total colony forming unit (CFU) number in LSK progeny (up to an 18.1-fold increase), and percentage of Lin-Sca1+ cells (up to a 31.8-fold increase). Importantly, these studies were corroborated by in vivo reconstitution studies in which LSK cells maintained in fresh OB co-cultures supported a significantly higher level of chimerism than cells maintained in co-cultures containing 3-week OBs. Characterization of OBs cultured for 1, 2, or 3 weeks with real-time PCR and functional mineralization assays showed that OB maturation increased with culture duration but was not affected by the presence of LSK cells in culture. Linear regression analyses of multiple parameters measured in these studies show that fresh, most likely more immature OBs better promote hematopoietic expansion and function than cultured, presumably more mature OBs and suggest that the hematopoiesis-enhancing activity is mediated by cells present in fresh OB cultures de novo. © 2011 American Society for Bone and Mineral Research.
Ethanol‐induced redox imbalance in rat kidneys
Authors: Nechifor Marina Tamara , Dinu Diana 
Published: November 2010

AbstractThis study reports the effects of long‐term ethanol consumption on kidney redox status, in terms of enzymatic mechanisms involved in regulating the cytosolic [NADH]/[NAD+] balance. Wistar rats were treated with ethanol (2 g/kg body weight/24 h) via intragastric intubation for 10 and 30 weeks, respectively. Ethanol administration induced an enhancement of alcohol dehydrogenase activities and affected the capacity of the kidney to prevent NADH accumulation in the cytosol. After 10 weeks, the excess of NADH was balanced by increased activities of malate dehydrogenase and aspartate transaminase. In the event of a longer period of ethanol intake, the kidney was not able to balance the NADH excess, even though an increase in malate dehydrogenase, lactate dehydrogenase, aspartate transaminase, and alanine transaminase activities was noted. The electrophoretic analysis of alcohol dehydrogenase, lactate dehydrogenase, and malate dehydrogenase isoforms revealed differences between control and ethanol‐treated animals. The results suggest that rat kidneys have a multicomponent metabolic response to the same daily dose of ethanol that functions to maintain the redox status and which varies with the length of the administration period. © 2010 Wiley Periodicals, Inc. J Biochem Mol Toxicol 25:224–230, 2011; View this article online at wileyonlinelibrary.com. DOI 10.1002/jbt.20379
Attachment style
Authors: Levy Kenneth N. , Ellison William D. , Scott Lori N. , Bernecker Samantha L. 
Published: November 2010

AbstractAttachment theory, developed by Bowlby to explain human bonding, has profound implications for conducting and adapting psychotherapy. We summarize the prevailing definitions and measures of attachment style. We review the results of three meta‐analyses examining the association between attachment anxiety, avoidance, and security and psychotherapy outcome. Fourteen studies were synthesized, which included 19 separate therapy cohorts with a combined sample size of 1,467. Attachment anxiety showed a d of −.46 with posttherapy outcome, while attachment security showed a d of.37 association with outcome. Attachment avoidance was uncorrelated with outcome. The age and gender composition of the samples moderated the relation between attachment security and outcome: samples with a higher proportion of female clients and a higher mean age showed a smaller relation between security and outcome. We discuss the practice implications of these findings and related research on the link between attachment and the therapy relationship. © 2010 Wiley Periodicals, Inc. J Clin Psychol: In Session 67:193–203, 2011.