bluuebunny/crossref_metadata_2025_split huggingface dataset:
Endoscopic-Assisted Cochlear Implantation in Far Advanced Otosclerosis
Authors: Salem Mohammed Abdelbadie , Ghonim Mohamed Rashad , Elzayat Saad , Elkahwagi Mohamed , Badr Khalid , Essawy Wessam Mostafa , Fouad Yasser Ahmed 
Published: May 2024

Objectives
To evaluate the effectiveness of cochlear implantation (CI) in case of far advanced otosclerosis and to evaluate the value of using intraoperative otoendoscopy to facilitate the identification of the round window membrane and the scala tympani without the need to remove the posterior canal wall or to perform a subtotal petrosectomy.

Study Design
Retrospective case-series study.

Setting
Tertiary academic CI center.

Patients and Methods
This study was conducted on patients with far advanced otosclerosis who underwent endoscopic-assisted CI between January 2010 and June 2020 at the same CI center. The minimum follow-up period was 2 years after surgery.

Results
Fourteen patients were included in the study. Ten patients had undergone a previous stapedotomy. Electrode insertion in the scala tympani was successfully accomplished in all cases included in the study. There was a statistically significant improvement in pure-tone average and speech discrimination scores in all cases of the study group (p < 0.0001). There were no statistically significant differences in postoperative pure-tone average or speech discrimination scores between cases with and without cochlear ossification or between cases with and without a previous stapedotomy (p > 0.05).

Conclusion
Endoscopic-assisted CI is an effective option for hearing restoration in patients with far advanced otosclerosis. Otoendoscopy can facilitate visualization and access to the scala tympani without the need to remove the posterior canal wall or to perform a subtotal petrosectomy.
Anesthetic management of a patient with dilated cardiomyopathy and purpura for interventional thrombectomy of both femoral artery: Case report
Authors: Wang Huazhen , Zhu Yingming , Nan Yongshan , Jin Xianglan 
Published: May 2024

Rationale:
Anesthesia management of patients with dilated cardiomyopathy (DCM) has always been a challenge for anesthesiologists. Eighty percent of patients with DCM have heart failure as the first symptom, which may be accompanied by arrhythmias, thromboembolism, etc. Thrombosis is a significant contributing factor to adverse cardiovascular and cerebrovascular events, and its risk is severely underestimated in the anesthetic management of DCM.

Patient concerns:
We present a case of a 54-year-old hypersensitive female patient with dilated cardiomyopathy and purpura who underwent an interventional thrombectomy under general anesthesia following a lower limb thromboembolism.

Diagnosis:
Patient underwent an interventional thrombectomy under general anesthesia, with in situ thrombosis occurring during the surgery.

Interventions:
After maintaining stable hemodynamics, proceed with the intervention to retrieve the embolus.

Outcome:
Patients in the advanced DCM developed acute thrombosis twice during embolization.

Lessons:
This case discusses the causes of intraoperative thrombosis and summarizes and reflects on the anesthesia management of this case, which has always been one of the difficult points for anesthesiologists to master. In the anesthesia management of DCM patients, it is also necessary to maintain hemodynamic stability, enhance perioperative coagulation management, use anticoagulants rationally, and avoid the occurrence of thrombotic events.
Philadelphia chromosome-positive acute myeloid leukemia successfully treated by allogeneic hematopoietic stem cell transplantation: A case report and review of the literature
Authors: Zhang Zhichen , Wang Xuan , Bai Jiaofeng , Yang Xiaolan , Lian Bianli , Zhang Yuexia , Kang Jin , Pan Yaozhu 
Published: May 2024

Rational:
The Philadelphia chromosome (Ph) is seen in most patients with chronic myeloid leukemia and some patients with acute lymphoblastic leukemia. However, Ph-positive acute myeloid leukemia (Ph + AML) is a rare entity with a poor prognosis and a short median survival period. To date, there have been few clinical reports on this disease. And the treatment regimen of this disease has not been uniformly determined.

Patient concerns:
We report a case of a Ph + AML. A 32-year-old male who was admitted to our hospital with weakness for 2 months.

Diagnosis:
Philadelphia chromosome-positive acute myeloid leukemia.

Interventions:
The patient achieved complete remission by the administration of a tyrosine kinase inhibitor, combined with low-intensity chemotherapy and a B-cell lymphoma 2 inhibitor. Then, allogeneic hematopoietic stem cell transplantation (allo-HSCT) from his sister was successfully performed.

Outcomes:
The patient has been in a continuous remission state for 6 months after transplantation.

Lessons:
We reported a rare Ph + AML case, successfully treated with allo-HSCT. This case provided strong support for treating Ph + AML with allo-HSCT.
Anti-Hu antibody associated paraneoplastic neurological syndrome in a child with ganglioneuroblastoma: A rare case report and literature review
Authors: Dai Yi-Ling , Xiao Ling , Pan Zhen , He Guo-Qian , Gao Ju , Guo Xia , Huang Zhuo 
Published: May 2024

Rationale:
Paraneoplastic neurological syndrome with anti-Hu antibody (Hu-PNS) is a neurological disorder that occur in patients with malignancy. The syndrome has a wide range of presentations and can present before diagnosis of primary malignancy. Familiarity with these paraneoplastic neurological syndromes can help early recognition and take appropriate regimens.

Patients concerns:
Diagnosis and treatment of Hu-PNS.

Diagnoses:
This is retrospective study that analyzed the clinical data of this case. Through retrospective analysis and targeted antibody screening, serum anti-Hu antibody was detected. Subsequent spinal imaging revealed a mass in the paraspinal region, which was confirmed as ganglioneuroblastoma by pathologic examination.

Interventions:
The child was treated with a course of intravenous immunoglobulin and radical surgical operation without chemotherapy.

Outcomes:
The neurological symptoms were gradually improved and no signs indicate disease progression or tumor recurrence.

Lessons:
Hu-PNS has rarely been reported in children with ganglioneuroblastomas. They can mimic non-neoplastic processes, making detection and diagnosis difficult. Serum and/or cerebrospinal fluid onconeural antibody can strongly indicate occult cancers. Early detection of paraneoplastic neurological syndromes can help take appropriate regimens and improve prognosis.
Impact of Baduanjin exercise combined with rational emotive behavior therapy on sleep and mood in patients with poststroke depression: A randomized controlled trial
Authors: Liu Yihan , Chen Chen , Du Hanbin , Xue Mengzhou , Zhu Ning 
Published: May 2024

Background:
Poststroke depression (PSD) is one of the most common stroke complications. It not only leads to a decline in patients’ quality of life but also increases the mortality of patients. In this study, the method of combining Chinese traditional exercise Baduanjin with psychotherapy was used to intervene in patients with PSD and to explore the improvement of sleep, mood, and serum levels of brain-derived neurotrophic factor (BDNF), 5-hydroxytryptamine (5-HT), and interleukin-6 (IL-6) levels in patients with PSD by combined treatment.

Methods:
A total of 100 patients with PSD who met the inclusion criteria were randomly assigned to Baduanjin group (n = 50) or control group (n = 50). The control group received treatment with escitalopram oxalate and rational emotive behavior therapy, while the experimental group received Baduanjin training in addition to the treatment given to the control group. Changes in sleep efficiency, sleep total time, sleep latency, arousal index, Hamilton Anxiety Rating Scale, Hamilton Depression Scale score, serum BDNF, 5-HT, IL-6 levels, and Modified Barthel Index were measured at baseline, 4 weeks and 8 weeks after intervention, and the results were compared between the 2 groups.

Results:
Significantly improvements in the sleep efficiency, sleep total time, serum 5-HT, BDNF levels, and Modified Barthel Index score were detected at week 4 in the Baduanjin group than in the control group (P < .05). Additionally, the sleep latency, arousal index, Hamilton Anxiety Rating Scale, Hamilton Depression Scale scores and IL-6 levels in the Baduanjin group were lower than those in the control group (P < .05). After 8 weeks of treatment, the above indexes in the Baduanjin group were further improved compared with the control group (P < .05), and the above indexes of the 2 groups were significantly improved compared with the baseline (P < .001).

Conclusion:
Baduanjin exercise combined with rational emotive behavior therapy effectively improves the mood and sleep status of patients with PSD; It increases the serum levels of 5-HT and BDNF while reducing the level of serum proinflammatory factor IL-6; additionally, the intervention alleviates the degree of neurological impairment, upgrades the ability of daily living, and improves the quality of life.
Lipid mediators in neutrophil biology: inflammation, resolution and beyond
Authors: Ghodsi Anita , Hidalgo Andres , Libreros Stephania 
Published: May 2024

Purpose of review
Acute inflammation is the body's first defense in response to pathogens or injury. Failure to efficiently resolve the inflammatory insult can severely affect tissue homeostasis, leading to chronic inflammation. Neutrophils play a pivotal role in eradicating infectious pathogens, orchestrating the initiation and resolution of acute inflammation, and maintaining physiological functions. The resolution of inflammation is a highly orchestrated biochemical process, partially modulated by a novel class of endogenous lipid mediators known as specialized pro-resolving mediators (SPMs). SPMs mediate their potent bioactions via activating specific cell-surface G protein-coupled receptors (GPCR).

Recent findings
This review focuses on recent advances in understanding the multifaceted functions of SPMs, detailing their roles in expediting neutrophil apoptosis, promoting clearance by macrophages, regulating their excessive infiltration at inflammation sites, orchestrating bone marrow deployment, also enhances neutrophil phagocytosis and tissue repair mechanisms under both physiological and pathological conditions. We also focus on the novel role of SPMs in regulating bone marrow neutrophil functions, differentiation, and highlight open questions about SPMs’ functions in neutrophil heterogeneity.

Summary
SPMs play a pivotal role in mitigating excessive neutrophil infiltration and hyperactivity within pathological milieus, notably in conditions such as sepsis, cardiovascular disease, ischemic events, and cancer. This significant function highlights SPMs as promising therapeutic agents in the management of both acute and chronic inflammatory disorders.
Shedding light on GPIbα shedding
Authors: Debaene Caitlin , Feys Hendrik B. , Six Katrijn R. 
Published: May 2024

Purpose of review
Ectodomain shedding has been investigated since the late 1980s. The abundant and platelet specific GPIbα receptor is cleaved by ADAM17 resulting in the release of its ectodomain called glycocalicin. This review will address the role of glycocalicin as an end-stage marker of platelet turnover and storage lesion and will consider a potential function as effector in processes beyond hemostasis.

Recent findings
Glycocalicin has been described as a marker for platelet senescence, turnover and storage lesion but is not routinely used in a clinical setting because its diagnostic value is nondiscriminatory. Inhibition of glycocalicin shedding improves posttransfusion recovery but little is known (yet) about potential hemostatic improvements. In physiological settings, GPIbα shedding is restricted to the intracellular GPIbα receptor subpopulation suggesting a role for shedding or glycocalicin beyond hemostasis.

Summary
So far, all evidence represents glycocalicin as an end-stage biomarker of platelet senescence and a potential trigger for platelet clearance. The extensive list of interaction partners of GPIbα in fields beyond hemostasis opens new possibilities to investigate specific effector functions of glycocalicin.
The Effect of Intratumor Heterogeneity in Pancreatic Ductal Adenocarcinoma Progression and Treatment
Authors: Saleh Othman , Shihadeh Hani , Yousef Ahmad , Erekat Hana , Abdallh Fatima , Al-leimon Ahmad , Elsalhy Rawan , Altiti Abdalrahman , Dajani Majd , AlBarakat Majd M. 
Published: May 2024

Background and Objectives
Pancreatic cancer is one of the most lethal malignancies. Even though many substantial improvements in the survival rates for other major cancer forms were made, pancreatic cancer survival rates have remained relatively unchanged since the 1960s. Even more, no standard classification system for pancreatic cancer is based on cellular biomarkers. This review will discuss and provide updates about the role of stem cells in the progression of PC, the genetic changes associated with it, and the promising biomarkers for diagnosis.

Materials and Methods
The search process used PubMed, Cochrane Library, and Scopus databases to identify the relevant and related articles. Articles had to be published in English to be considered.

Results
The increasing number of studies in recent years has revealed that the diversity of cancer-associated fibroblasts is far greater than previously acknowledged, which highlights the need for further research to better understand the various cancer-associated fibroblast subpopulations. Despite the huge diversity in pancreatic cancer, some common features can be noted to be shared among patients. Mutations involving CDKN2, P53, and K-RAS can be seen in a big number of patients, for example. Similarly, some patterns of genes and biomarkers expression and the level of their expression can help in predicting cancer behavior such as metastasis and drug resistance. The current trend in cancer research, especially with the advancement in technology, is to sequence everything in hopes of finding disease-related mutations.

Conclusion
Optimizing pancreatic cancer treatment requires clear classification, understanding CAF roles, and exploring stroma reshaping approaches.
Exposure of Undergraduate Nursing Students to Standing Environments
Authors: Bernardes Rafael A. , Caldeira Sílvia , Stolt Minna , Almeida Inês F. , Simões Jéssica , Paulo Íris , Magalhães Ana Sofia , Cruz Arménio 
Published: May 2024

Background:
Understanding the link between plantar force, pressure, and foot discomfort is important for nursing students’ well-being, given the prevalence of foot and ankle musculoskeletal disorders among nurses. Assessing these factors can inform tailored self-care interventions, supporting holistic nursing education.

Purpose:
To assess the plantar force and pressure distribution of third-year nursing students at baseline and after 5 months of exposure to a clinical setting.

Methods:
A prospective cohort study in a Portuguese nursing school measured changes in podiatric profile at 5 months, including peak pressure, maximum force, and contact area.

Results:
Elevated mean peak pressure in the heel correlated positively with maximum force and contact area. Negative correlations were found between the contact area and edema. Peak pressure correlated positively with thigh pain, indicating pressure transfer to metatarsal heads.

Conclusions:
The findings underscore the importance of integrating ergonomic education into nursing curricula and raising awareness of self-care interventions.
Geographic Proximity of Medical Students to PM&R Residency Programs Is Associated With Increased Match Rates Into PM&R
Authors: Oxspring Milan , Barnes Riley , Klanderman Molly , Yoo Min 
Published: May 2024

Abstract
Despite the growing popularity of physical medicine and rehabilitation as a specialty among medical students, meaningful experiences and mentorship can be challenging to obtain and may significantly vary depending on opportunities available to interact with physiatrists. This study explores the association between the geographic proximity of physical medicine and rehabilitation residency programs to medical schools and the match rate of medical students into physical medicine and rehabilitation from 2019 to 2021. Data on US medical schools, graduates, and physical medicine and rehabilitation residency programs were collected from publicly available sources, and a sample of 1193 physical medicine and rehabilitation residents from US medical schools was analyzed using a one-sample proportion test. The proportion of physical medicine and rehabilitation residents originating from medical schools with physical medicine and rehabilitation residency programs in the same metropolitan area was significantly greater than the corresponding proportion of expected residents based on medical school graduates, even when controlling for medical school affiliations with physical medicine and rehabilitation residency programs. These findings suggest that exposure and opportunities provided by physical medicine and rehabilitation residency programs may influence nearby medical students and that expanding residency programs into geographic regions without existing physical medicine and rehabilitation programs may foster interest and promote growth in the field of physiatry.
Physiotherapeutic Scoliosis-Specific Exercise for the Treatment of Adolescent Idiopathic Scoliosis
Authors: Dong Huanrun , You Mengjia , Li Yaning , Wang Bingjie , Huang Hailiang 
Published: May 2024

Objective
The aim of the study is to compare the rehabilitative efficacy of different physiotherapy scoliosis-specific exercises for adolescent idiopathic scoliosis using a network meta-analysis.

Design
PubMed, Cochrane Library, Web of Science, Embase, VIP Database for Chinese Technical Periodicals, China National Knowledge Infrastructure, Chinese Biomedical Literature Database, and Wan Fang Data were searched until October 2023. Meta-analysis and network meta-analysis were conducted using RevMan 5.4 and R4.3.1. This study follows the Preferred Reporting Items for Systematic Evaluation and Network Meta-analysis statement and was registered on the PROSPERO platform (no. CRD42022379206).

Results
Seventeen randomized controlled trials (RCTs) involving 857 patients were included. The meta-analysis showed that physiotherapy scoliosis-specific exercise therapy improved Cobb’s angle than conventional rehabilitation therapy (standardized mean difference = −0.7; 95% confidence interval = −0.95, −0.44; P = 0.001), angle of trunk rotation (standardized mean difference = −1.05; 95% confidence interval = −1.52, −0.58; P < 0.001), and quality of life (standardized mean difference = 0.61; 95% confidence interval = 0.16, 1.07; P < 0.001). Network meta-analysis showed that Schroth + scientific exercise approach to scoliosis was the most effective in improving Cobb angle and angle of trunk rotation, while Schroth alone was most effective in improving the quality of life.

Conclusions
The combination of Schroth and Schroth + scientific exercise approach to scoliosis improved the body posture and trunk deformity in patients with adolescent idiopathic scoliosis, while Schroth alone improved the quality of life. The effectiveness of combining different physiotherapy scoliosis-specific exercise techniques supports future evidence-based research on adolescent idiopathic scoliosis treatment.
Pectoralis Major Tendon Rupture in a Spastic Hemiplegic Shoulder
Authors: Zainudin Muhamad Faizal , Cha Mei Yee , Aziz Ahmad Fuad Ab 
Published: May 2024

Abstract
Pectoralis major injuries are uncommon, typically affecting young male athletes engaging in high-intensity activities like weightlifting. A 62-yr-old man, who previously suffered a stroke leading to left hemiparesis, hemisensory loss, and spasticity, exhibited a left chest swelling during a rehabilitation clinic visit. Subsequent inquiries revealed his recent incorporation of a home-based pulley system for stretching exercises. On examination, the swelling was diffuse, firm, and nontender, located at the midclavicular line of his left chest, with a positive dropped nipple sign and loss of the left anterior axillary fold sign. An ultrasound confirmed a low-grade injury to the left pectoralis major tendon. Spastic muscle ruptures are extremely rare, with only three published reports linked to traumatic brain injury, multiple sclerosis, and spinal cord injury. Spasticity increases muscle vulnerability due to structural and mechanical changes to the skeletal muscles. This is the first report of a spastic pectoralis major tendon rupture and the first after a stroke. This case highlights the need for optimized multimodal spasticity management and reinforces the importance of comprehensive patient education on the safe execution of home-based stretching exercises.
Prospective Bidirectional Relationship Between Sleep Duration and Posttraumatic Stress Disorder Symptoms After Suspected Acute Coronary Syndrome
Authors: Cornelius Talea , Edmondson Donald , Abdalla Marwah , Scott Allie , Fernandez Sedano Brandon , Hiti David , Sullivan Alexandra M. , Schwartz Joseph E. , Kronish Ian M. , Shechter Ari 
Published: May 2024

Objective
Sleep disturbance is a “hallmark” symptom of posttraumatic stress disorder (PTSD). Poor sleep (including short sleep) after combat-related trauma can also predict subsequent PTSD. Less is known about the association between sleep duration and PTSD symptoms when PTSD is induced by acute coronary syndrome (ACS). We examined the bidirectional relationship between sleep duration and PTSD symptoms over the year after hospital evaluation for ACS.

Methods
Participants were enrolled in this observational study after emergency department evaluation for ACS. Sleep duration (“During the past month, how many hours of actual sleep did you get at night?”) and cardiac event or hospitalization-induced PTSD symptoms (PTSD Checklist) were assessed at 1, 6, and 12 months after hospital discharge. Cross-lagged path analysis was used to model the effects of sleep duration and PTSD symptoms on each other. Covariates included age, sex, race/ethnicity, cardiac severity, baseline depression symptoms, and early acute stress disorder symptoms.

Results
The sample included 1145 participants; 16% screened positive for probable PTSD (PTSD Checklist score ≥33). Mean sleep duration across time points was 6.1 hours. Higher PTSD symptoms predicted shorter sleep duration at the next time point (i.e., 1–6 and 6–12 months; B = −0.14 hours/10-point difference, SE = 0.03, p < .001). Shorter sleep duration was associated with higher PTSD symptoms at the next time point (B = −0.25 points/hour, SE = 0.12, p = .04).

Conclusions
Short sleep duration and PTSD symptoms are mutually reinforcing across the first year after ACS evaluation. Findings suggest that sleep, PTSD symptoms, and their relationship should be considered in the post-ACS period.