bluuebunny/crossref_metadata_2025_split huggingface dataset:
Resveratrol Synthesis, Metabolism, and Delivery: A Mechanistic Treatise
Authors: Islam Fakhar , Shehzadi Umber , Saeed Farhan , Shabir Ahmad Rabia , Umair Arshad Muhammad , Sadiq Naseer Muhammad , Tariq Fatima , Ali Rehman , Khurshid Sadaf , Hussain Ghulam , Ahmad Aftab , Afzaal Muhammad , Akram Rabia , Tuncay Agar Osman , Imran Ali , A.R. Suleria Hafiz 
Published: May 2024

Resveratrol, a bioactive phytochemical classified as a phytoalexin present in plant sources, is recognized for its distinct characteristics such as anticancer, chemoprotective, chemosensitizer, neuroprotective, anti-inflammatory, and antioxidant properties. Resveratrol is a polyphenol that increases the susceptibility of cancer-resistant cells to chemotherapy. Resveratrol also aids in weight loss by decreasing lipogenesis, the prevention of neurological illnesses, and other topical uses such as the treatment of skin hyperpigmentation. During the past 10 years, resveratrol, a naturally occurring stilbene found in various foods and drinks, has drawn increased interest due to its many health benefits, including its chemo-preventive and anticancer actions. Several naturally occurring resveratrol derivatives can be found in food and share a similar structural makeup with resveratrol. To boost the effectiveness and activity of particular resveratrol features, several resveratrol analogues have also been created by the addition of designated functional groups. Such resveratrol derivatives might provide beneficial cancer therapeutics and cancer chemo-preventive drugs for cancer prevention and therapy. However, the quest for the identification of new analogues with high yield must be explored to extend resveratrol effectiveness. This chapter provides an overview of the most significant resveratrol derivatives used to treat cardiovascular diseases and the methods of their synthesis.
Identification of a new disease gene for a familial autoimmune disease
Authors:   , Sinthuwiwat Thivaratana 
Published: May 2024

Background: Autoimmune diseases, triggered by genetic and environmental factors resulted in the failure of the immune system to develop tolerance toward self-antigens, are characterized by immune responses against self-tissues. Until now the cause of autoimmune disease is not well understood. Here, we identified a three-generation family with 9 members suffering from one of the three autoimmune diseases – Grave’s disease, Hashimoto thyroiditis, or SLE. Objective: To identify a genetic variant underlying the autoimmune diseases of this large family and to determine its molecular pathomechanism. Methods: Immunophenotype including flow cytometry was characterized. Whole-genome linkage study (WGL) and whole-exome sequencing (WES) of all 9 affected family members were performed. Phosphorylation of the mutated and its downstream proteins were studied. Single-cell RNA sequencing (scRNA-seq) was studied using peripheral blood mononuclear cell of three patients and a healthy control. Results: Immunophenotype shows no differences in percentage and expression of ILT2 in immune cells. WGL revealed a locus on chromosome 19 with the maximum LOD score of 2.04. WES identified a heterozygous missense mutation, c.479G>A (p. G160E) in ILT2, located within the linked region, in all affected members. PCR-Sanger sequencing confirmed the identified mutation. The mutation segregated with the disease phenotype in family with 75% penetrance. Jurkat cells transfected with the mutant ILT2, compared to those with wild-type ILT2, showed decreased phosphorylation of both ILT2 and SHP-1, an ILT2’s downstream molecule. scRNA-seq showed significantly increased percentage of M2 monocyte subsets in the three patients, compared to the control. Notably, M1 monocyte subsets, which was previously observed to play a role in inflammation and autoimmune diseases, in patients were not different from the control. Conclusion: A variant in ILT2 leading to decreased phosphorylated ILT2, and SHP-1 is associated with autoimmune diseases in a large family. This is the first time to implicate ILT2 as a possible new disease gene for autoimmunity.
Pengembangan Karakter dalam Upaya Meningkatkan Prestasi Siswa Sekolah Dasar Jambe Anom 1 Bondowoso
Authors: Wardhono Adhitya , Qori’ah Ciplis Gema , Puspito Agung Nugroho , Ubaidillah Mohammad , Kristianawati Fany Indah , Febriani Nawal Aprodita , Sinulingga Trisna Handayani BR , Affiana Alfina Nur , Wijayanti Karmila Dwi , Salsabila Ayu , Nasir M Abd 
Published: May 2024

This study aims to evaluate and analyze the impact of the implementation of character development programs at SDN Jambe Anom 1. The focus of the study is to increase student motivation and achievement. Qualitative research is more investigative to produce data that cannot be obtained through statistical procedures. This character development program includes reinforcing positive values, ethics, and an attitude of responsibility. This research also carried out several activities to motivate students, such as sharing experiences and allowing students to express their dreams. In addition, this study also conducted several activities to improve student achievement. The results of this research are expected to encourage SDN Jambe Anom 1 students to achieve their goals
How to Transfer Ownership of Real Estate to Individuals by Settlement, Or by Registration
Authors: Alresheidat Mamdouh Mohd Mamdouh , Al-Zubaidi Muhammad Awad 
Published: May 2024

Real estate is characterized as stable money that is suitable for production and exploitation over time, this study Looking for an answer to the following question: How to transfer the ownership of real estate to individuals through settlement, or registration? The study found that The real estate owned by the state is of three types: the first is real estate designated for public benefit, and the second is real estate owned by the state, private ownership, i.e. registered in the name of the treasury or one of its institutions, and real estate owned by the state by definition, that is, unregistered real estate.and The transfer of ownership of state-owned real estate to individuals, includes registered and unregistered lands, where individuals can register state lands in their own name, provided permission from the state, through the acts of the provisions of the real estate ownership law, whether by settlement or registration. and If the ownership is transferred to individuals, according to the settlement of land and water, or the registration of immovable property that has not previously been registered, then the title deed is considered an official document, and its contents cannot be challenged by any means of appeal, not even by fraud or forgery. After that, the title deed has the right to challenge it, for any defect in the elements of the contract or a succession in the implementation of the contract, before the regular courts, to demand the invalidity or rescission of the act.
Knowledge and Practice of Pelvic and Acetabular Fractures Management Among Orthopaedics and Trauma Surgeons in Nigeria
Authors: Ogunlusi JOHNSON , Yusuf MORUF , Hailu SAMUEL , Olasinde ANTHONY , Popoola SUNDAY Ogunsuyi , Esan OLUWADARE , Oluwadiya KEHINDE 
Published: May 2024

Background: Pelvic-acetabular fractures are markers of high energy trauma and are associated with significant morbidity, mortality and management could be challenging. The inability to surgically manage these fractures appropriately in our centre and few publications on pelvic-acetabular fractures in Nigeria stimulated this study.
Objectives: to find out how pelvic and acetabular fractures are managed and availability of investigating tools in Nigeria.
Materials and methods: A questionnaire was uploaded for 7 weeks on the National orthopaedics and trauma surgeons’ forum. Questions on pelvic fractures management, knowledge and classification of pelvic fractures, preferred methods of pelvic fractures management- surgical or non-surgical, availability of advanced investigating tools and desire to acquire more skills /training were asked.
Results: Eighty-five (33.2%) of the 256 members participated in the study. Preferred classification were Tile and Young-Burgess 46 (56.8%) and 29 (35.8 %) respectively. Thirty-six (43.9%) had Computerize Tomography scan (CT) while 19 (23.2%) had Magnetic Resonance Imaging (MRI) available in their place of practice. Twenty-eight (34.6%) would manage operatively, 8 (9.9%) would either operate or refer, while 23 (28.48%) would either manage non-operative or refer and outright non-operative in 7 (8.6%) of pelvic-acetabular fractures that require Open Reduction Internal Fixation (ORIF). Forty-six (56.8%) would refer patients; because of non-availability of skilled surgeon in 30(65.2%) and non-availability of operating tools in 32(69.6 %). Seventy-four (90.2%) would like to acquire skills in pelvic surgery.
Conclusion: The health facilities were not adequately equipped with advanced imaging tools. Twenty-three percent of the respondents would consider managing pelvic fracture that requires ORIF non-operatively, while more than half would refer because of either non-availability of skilled pelvic surgeon or non-availably of operating tools. Majority of the respondents are interested in acquiring skills in pelvic surgery.
Lecciones únicas e hipotexto del Catón en romance de Gonzalo García de Santa María: el incunable poético 93*CA
Authors: Marini Massimo 
Published: May 2024

Resumen: El trabajo se propone estudiar una selección de glosas poéticas en romance que Gonzalo García de Santa María realizó sobre los Disticha Catonis y que vieron la luz en Zaragoza alrededor de 1493, en la imprenta de Pablo Hurus (93*CA). Siguiendo el método de la collatio subyacente, se demostrará la acción que el hipotexto latino pudo ejercer sobre el texto castellano, para estudiar las relaciones textuales que se establecen entre el modelo y su glosa tanto a nivel sincrónico, en la operación hermenéutica que lleva a cabo el traductor, como a nivel diacrónico, en la compleja estratificación que supone la historia de la transmisión de los Disticha. La reflexión crítica abordará tanto la sección de monóstico de la obra como la de los dísticos propiamente dichos.

Palabras clave: Disticha Catonis, Gonzalo García de Santa María, glosa, traducción, imprenta incunable

Abstract: The aim of this paper is to study a selection of Spanish poetic glosses that Gonzalo García de Santa María made on the Disticha Catonis, published in Zaragoza around 1493, by Pablo Hurus (93*CA). Following the method of the underlying collatio, the action that the Latin hypotext could have exerted on the Castilian text will be demonstrated, in order to study the textual relations established between the model and its gloss both at a synchronic level, in the hermeneutic operation carried out by the translator, and at a diachronic level, in the complex stratification that the history of the transmission of the Disticha implies. Critical reflection will address both the monostic section of the work and the distichs themselves.

Keywords: Disticha Catonis; Gonzalo García de Santa María; gloss; traslation; incunable printing
Pere Vicent Sabata, autor anònim: sobre els goigs del Ms. 804 de la BHUV
Authors: Mahiques Climent Joan 
Published: May 2024

Resum: El ms. 804 de la Biblioteca Històrica de la Universitat de València és una col·lecció factícia de goigs en castellà que, en bona part, són fulls impresos datats o datables del segle XVIII. L’article comença amb un esbós general sobre el contingut i les característiques d’aquest volum. Després, se centra en alguns goigs manuscrits atribuïts a Pere Vicent Sabata conservats en el ms. 804 o en el ms. 3619 de la Biblioteca de Catalunya. Finalment, a partir d’una anàlisi de l’estil i de les relacions intertextuals, es fa una proposta d’atribució de tres poesies més, dues d’elles impreses, que fins ara mai no havien estat assignades a Pere Vicent Sabata. L’article es clou amb la transcripció de vuit obres poètiques del gènere gogístic escrites o atribuïdes a l’autor susdit.

Paraules clau: segle XVIII, goigs, poesia anònima, autoria, Pere Vicent Sabata, edició

Abstract: The Ms. 804 of the Biblioteca Històrica of the University of Valencia is a miscellany volume of “goigs” (popular religious songs) printed, for the most part, in Spanish as broadsides dated from the 18th century, explicitly or not. This paper begins with an overview of the content and characteristics of this volume. Then it focuses on a few handwritten “goigs” attributed to Pere Vicent Sabata which have been preserved in the Ms. 804 or in the Ms. 3619 of the Biblioteca de Catalunya. Finally, three more poems -two of them printed- are attributed to him through an analysis of the style and intertextual relationships. Until now any of them had never been attributed to Pere Vicent Sabata. This paper concludes with the transcription of eight “goigs” written or attributed to the aforementioned author.

Keywords: 18th century, “goigs” (popular religious songs), anonymous poetry, authorship, Pere Vicent Sabata, editing
Assessing program outcomes from the bottom‐up approach: An innovative perspective to outcome evaluation
Authors: Chen Huey T. , Garbe Paul 
Published: June 2011

AbstractThe traditional top‐down approach to program outcome evaluation stresses the need for strong evidence to establish an intervention's effectuality. This approach's principles and methodology are rooted in Campbellian typology and have been applied intensively in outcome evaluation. Yet lessons learned from such applications suggest that in addressing stakeholders' interests and needs, this approach has limitations. To be stakeholder responsive, evaluation must go beyond the top‐down approach's focus and strategies. This chapter proposes an integrative validity model and a bottom‐up approach as an alternative perspective to outcome evaluation. The new perspective enables evaluations to meet both scientific and practical requirements and enhances evaluations' usefulness. © Wiley Periodicals, Inc., and the American Evaluation Association.1This article is a US Government work and, as such, is in the public domain in the United States of America.
Interaction among deer in a chronic wasting disease endemic zone
Authors: Silbernagel Erin R. , Skelton Nicole K. , Waldner Cheryl L. , Bollinger Trent K. 
Published: June 2011

AbstractAlthough it is known that chronic wasting disease (CWD) can be transmitted by both direct animal‐to‐animal contact and contact with contaminated environments, the relative role of each mechanism in the spread of CWD in free‐ranging populations has yet to be defined. We investigated patterns of interaction between mule deer (Odocoileus hemionus) in order to understand how factors such as season and landscape may influence patterns of disease spread in these populations. Using location data from male and female Global Positioning System (GPS)‐collared mule deer in 5 study areas located in and around a CWD‐endemic zone in southern Saskatchewan, Canada, we quantified close proximity events, or events involving both spatial and temporal overlap of individuals. We defined close proximity events as occurrences in which 2 deer were located <25 m apart at the same point in time. We looked at seasonal variation in the probability of close proximity events, as well as landscape factors associated with these events when compared to areas of shared space use, or spatial overlap alone. Overall probability of an individual GPS‐collared deer being located in close proximity to another GPS‐collared deer was 0.092 (n = 107). The early gestation (16 Dec–31 Mar) and late gestation (1 Apr–15 May) seasons had the highest probability of close proximity events occurring, and same‐sex pairs were more likely to be found in close proximity than between‐sex pairs during all seasons aside from the rut (1 Nov–15 Dec). High probability of close proximity events during the gestation seasons agrees with the tendency of mule deer to aggregate into large groups during late winter and suggests that this may be an important time period for CWD transmission to occur. Close proximity events occurred more in cropland and wetland than expected based on availability, whereas close proximity events occurred less than expected in grassland. The opposite was true for spatial overlap between individuals, which occurred more than expected in areas of low elevation and rugged terrain and in grassland or shrub–wood habitats. These results suggest that cropland may be a higher risk habitat for direct and indirect CWD transmission between individuals and that, although coulees and other areas of rugged topography are less likely to be associated with close proximity events, those areas may be more likely to contain environmental contamination in CWD‐affected areas due to common use by multiple deer. © 2011 The Wildlife Society.
Reduced expression of MUTYH with suppressive activity against mutations caused by 8‐hydroxyguanine is a novel predictor of a poor prognosis in human gastric cancer
Authors: Shinmura Kazuya , Goto Masanori , Suzuki Masaya , Tao Hong , Yamada Hidetaka , Igarashi Hisaki , Matsuura Shun , Maeda Matsuyoshi , Konno Hiroyuki , Matsuda Tomonari , Sugimura Haruhiko 
Published: June 2011

AbstractThe MUTYH gene encodes a DNA glycosylase that can initiate the excision repair of adenine mispaired with 8‐hydroxyguanine (8OHG) and is responsible for a susceptibility to multiple colorectal adenomas and carcinomas. To determine whether the MUTYH gene is involved in gastric carcinogenesis, we first examined the expression level of MUTYH in gastric cancer. The reduced expression of MUTYH mRNA transcript was detected in both gastric cancer cell lines and primary gastric cancers using qRT–PCR analysis. Immunohistochemical analysis also showed a significant reduction in MUTYH protein expression in gastric cancer, compared with non‐cancerous gastric epithelium (immunohistochemical score, 175.5 ± 43.0 versus 281.5 ± 24.8; p < 0.0001). Among the gastric cancers, the MUTYH expression level was significantly associated with the histopathology (p < 0.0001) and the pT stage (p < 0.001). The outcome of patients with gastric cancer exhibiting low MUTYH expression was significantly worse than the outcome of patients with gastric cancer exhibiting high MUTYH expression (p = 0.0007, log‐rank test) and a multivariate analysis revealed that reduced MUTYH expression was an independent predictor of a poor survival outcome among the gastric cancer patients (hazard ratio, 1.865; 95% confidence interval, 1.028–3.529; p = 0.0401). We next compared the functional effects of MUTYH on gastric cancer cells, based on their MUTYH expression levels. MUTYH‐over‐expressing stable clones of the gastric cancer cell line AGS showed: (a) higher DNA cleavage activity towards adenine:8OHG mispair‐containing substrates; (b) higher suppressive activity against mutations caused by 8OHG in a supF forward mutation assay; and (c) higher suppressive activity for cellular proliferation than empty vector‐transfected AGS clones. These results suggested that MUTYH is a suppressor of mutations caused by 8OHG in gastric cells and that its reduced expression is associated with a poor prognosis in gastric cancer. Copyright © 2011 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
Why does institutionalised care not appeal to Indian families? Legislative and social answers from urban India
Authors: BRIJNATH BIANCA 
Published: June 2011

ABSTRACTIn India, although notions of ageing and care are changing, there is a continued preference among families for home-based care of elderly relatives. The legislative policies and cultural practices that shape this preference will be examined in this paper with specific reference to aged-care facilities and the 2007Maintenance and Welfare of Parents and Senior Citizens Act. Using qualitative data from a study on dementia care in urban India it will be shown how the Act and old-age homes are understood and experienced by Indian families and key service providers. In juxtaposing policy and practice it will be argued that while notions of care are being redefined by processes like migration and urbanisation, the preference for home care remains, indicating that existing services need to be re-oriented and expanded to support families in providing this care.
A 2.45-GHz dual-diode rectenna and rectenna arrays for wireless remote supply applications
Authors: Takhedmit Hakim , Cirio Laurent , Merabet Boubekeur , Allard Bruno , Costa François , Vollaire Christian , Picon Odile 
Published: June 2011

This paper describes a compact and efficient rectenna based on a dual-diode microstrip rectifier at 2.45 GHz. This circuit has been designed and optimized using a global analysis technique which associates electromagnetic and circuit approaches. Due to the differential topology of the rectifier, neither input low-pass filter nor via-hole connections are needed. This makes the structure more compact reducing losses. Measurements of a single rectenna element show 83% efficiency over an optimal load of 1050 Ω at a power density of 0.31 mW/cm2. To increase the received RF power and then increase dc power over the load, identical rectennas have been interconnected to form arrays. Two and four elements rectenna arrays, connected either in parallel or in series, have been developed. It was shown that by properly choosing the interconnection topology and the optimal output load, higher dc voltage or dc power have been obtained. The four-element series-connected array can provide experimentally up to 3.85 times output dc voltage compared to the single rectenna. The parallel-connected rectenna arrays generate approximately 2.15 and 3.75 times output dc power for two and four elements, respectively.