bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sumatriptan–Naproxen Migraine Efficacy in Allodynic Patients: Early Intervention
Authors: Landy Stephen , Hoagland Rebecca , Hoagland Nancy A. 
Published: September 2011

Objective.— This study evaluated the effectiveness of a single fixed‐dose tablet of sumatriptan 85 mg/naproxen sodium 500 mg (sumatriptan–naproxen) using a very early treatment paradigm in migraine patients whose attacks were historically accompanied by cutaneous allodynia.Background.— Evidence suggests that allodynic migraineurs may demonstrate a better response when treated prior to developing central sensitization, and that these patients are treated more effectively with a compound of sumatriptan and naproxen sodium than either drug alone. This study targeted patients who have accompanying allodynia using a very early treatment paradigm where treatment was initiated while symptoms were still mild.Methods.— This was an open‐label prospective, outpatient study of adult migraineurs who had screened positive for cutaneous allodynia and typically experienced moderate to severe pain preceded by an identifiable mild pain phase. Patients were treated with sumatriptan–naproxen using a very early intervention paradigm in 4 test migraines over 12 weeks where dosage occurred within 30 minutes of symptom onset. Data from diaries and questionnaires were used to evaluate the primary endpoints of sustained pain‐free response at 24 hours post dose (using no second dose of study drug and no other rescue drugs), and overall satisfaction with sumatriptan–naproxen.Results.— Forty allodynic migraineurs enrolled in this study and reported a total of 160 migraines. Of these migraines, 78 (49%) achieved sustained pain‐free at 24 hours and 94 (59%) were reported as pain‐free at 2 hours. The number of patients who rated their Overall Satisfaction following treatment with sumatriptan–naproxen as “Satisfied” (satisfied or very satisfied) was 32 (80%) after the first migraine and 25 (63%) after 3 or more migraines.Conclusions.— In this open‐label study, allodynic patients reported that their migraine attacks responded well and they achieved a high degree of satisfaction following treatment with a fixed‐dose tablet of sumatriptan 85 mg/naproxen sodium 500 mg administered in a very early treatment paradigm.
Cortisol, Insulin, and Glucose and the Risk of Delirium in Older Adults with Hip Fracture
Authors: Bisschop Peter H. , de Rooij Sophia E. , Zwinderman Aeilko H. , van Oosten Hannah E. , van Munster Barbara C. 
Published: September 2011

OBJECTIVES: To determine the relationship between perioperative delirium and cortisol, glucose, and insulin in older adults acutely admitted for hip fracture.
DESIGN: Prospective cohort study.
SETTING: Tertiary university center.
PARTICIPANTS: Consecutive individuals aged 65 and older acutely admitted for hip fracture were invited to participate.
MEASUREMENTS: All participants were repeatedly examined to determine presence and severity of delirium. Blood samples for cortisol, glucose, and insulin were drawn at 11:00 a.m. Differences in characteristics of participants with and without delirium were evaluated using t‐tests and Mann‐Whitney tests. A logistic regression analysis was performed to correct for other important risk factors for delirium.
RESULTS: One hundred forty‐three participants, 70 (49%) with delirium and 73 (51%) without, were included. In univariate analyses, there was a trend toward higher cortisol levels (odds ratio=1.003 (95% confidence interval=1.001–1.004, P=.004), but this association was not statistically significant after multivariable analysis and may reflect an association between high cortisol and preexisting cognitive and functional impairment, and there was no association with insulin or glucose levels. Adjusting for sex and prefracture cognitive and functional impairment made the trend with cortisol and delirium statistically nonsignificant.
CONCLUSION: Delirium in older adults acutely admitted for hip fracture may be linked with higher cortisol concentrations, but it may be that this association reflects an association between higher cortisol and preexisting cognitive and functional impairment.
Effect of Chronic Disease–Related Symptoms and Impairments on Universal Health Outcomes in Older Adults
Authors: Tinetti Mary E. , McAvay Gail , Chang Sandy S. , Ning Yuming , Newman Anne B. , Fitzpatrick Annette , Fried Terri R. , Harris Tamara B. , Nevitt Michael C. , Satterfield Suzanne , Yaffe Kristine , Peduzzi Peter 
Published: September 2011

OBJECTIVES: To determine the extent to which disease‐related symptoms and impairments, which constitute measures of disease severity or targets of therapy, account for the associations between chronic diseases and universal health outcomes.
DESIGN: Cross‐sectional.
SETTING: The Cardiovascular Health Study (CHS) and the Health, Aging and Body Composition Study (Health ABC).
PARTICIPANTS: Five thousand six hundred fifty‐four CHS members and 2,706 Health ABC members.
MEASUREMENTS: Diseases included heart failure (HF), chronic obstructive pulmonary disease (COPD), osteoarthritis, and cognitive impairment. The universal health outcomes included self‐rated health, basic and instrumental activities of daily living (ADLs and IADLs), and death. Disease‐related symptoms and impairments included HF symptoms and ejection fraction (EF) for HF, Dyspnea Scale and forced expiratory volume in 1 second for COPD, joint pain for osteoarthritis, and executive function for cognitive impairment.
RESULTS: The diseases were associated with the universal health outcomes (P<.001) except osteoarthritis with death (both cohorts) and cognitive impairment with self‐rated health (Health ABC). Symptoms and impairments accounted for 30% or more of each disease's effect on the universal health outcomes. In CHS, for example, HF was associated with one fewer (0.918) ADL and IADL performed without difficulty than no HF; HF symptoms accounted for 27% of this effect and EF for only 5%. The hazard ratio for death with HF was 6.5 (95% confidence interval=4.7–8.9) with EF accounting for 40% and HF symptoms for only 14%.
CONCLUSION: Disease‐related symptoms and impairments accounted for much of the significant associations between the four chronic diseases and the universal health outcomes. Results support considering universal health outcomes as common metrics across diseases in clinical decision‐making, perhaps by targeting the disease‐related symptoms and impairments that contribute most strongly to the effect of the disease on the universal health outcomes.
Pre‐Prosthetic Orthodontic Treatment Using Personalized Elastic Separators for Optimization of Emergence Profile in Esthetic Crowns: A Clinical Report
Authors: Freitas‐Júnior Amilcar C. , Silva Antonio M. 
Published: September 2011

AbstractRestoring a misaligned tooth with an inadequate contact point is a challenge to the practitioner. In some instances, teeth that could be repositioned and adequately restored are extracted. Thus, the aim of this article was to describe a treatment using orthodontic and prosthetic techniques to restore esthetics and function in a patient with a distally drifted maxillary lateral incisor. The patient's functional and esthetic expectations were successfully met with the outlined treatment.
A 10‐Year Survey of US Deans: Trends, Challenges, and Mentoring in Prosthodontics. Part 2
Authors: Chang Brian M. , Munoz Deborah M. , Donoff R. Bruce , Kinnunen Taru , Wright Robert F. 
Published: September 2011

AbstractPurpose: Part 2 of this survey reports on the 2009 survey findings distributed to the deans of US dental schools. A national, electronic survey of 58 dental school deans was distributed by e‐mail to evaluate an interest in specialty training, an interest in specialty training in prosthodontics, faculty shortage issues, predoctoral curriculum in prosthodontics, ideology regarding dental specialties, and the administrative position of prosthodontics within the schools.Materials and Methods: The survey data were transferred to an online spreadsheet program for statistical analysis (Key Survey, Inc. http://www.keysurvey.com, Braintree, MA). The opinions of dental school deans were viewed as legitimate indicators of change within predoctoral and postdoctoral prosthodontic education. Statistical analysis was carried out using Statistica Version 9.1 (Statsoft, Tulsa, OK).Results: Of the 58 deans, 42 deans responded, for a 72.4% response rate. Twenty‐three deans reported an increase in the number of students seeking specialty training after dental school. Only three deans reported a decrease in those seeking specialty training. In the 2009 survey, 45% the deans responded that there was an increased interest in prosthodontics. One or more open faculty positions in prosthodontics existed at 24 (59%) of the dental schools, and 30 (71%) offered at least one incentive or a variety of incentives to recruit faculty. The 2009 respondents to the deans’ survey revealed predoctoral student exposure to prosthodontists was high, and exposure to advanced education in prosthodontics students was low. A survey of internal school programs that might have an impact on an increased interest in prosthodontics revealed the presence of a predoctoral mentoring program for prosthodontics in 36 (88%) of the institutions. The clinical curriculum included treatment of a variety of cases including complex cases as defined by a diagnostic classification system. The 2009 survey respondents reported an increase in the number of schools where prosthodontics is a separate entity or department.Conclusion: Deans reported an increased interest in prosthodontics in the 2009 survey. Open faculty positions in prosthodontics existed in the majority of dental schools, and most schools offered incentives to recruit faculty. The survey of deans found a very high level of exposure of dental students to full‐time prosthodontists and a very low exposure level to students enrolled in advanced education in prosthodontics. The establishment of mentoring programs in prosthodontics was reported by most deans, and the predoctoral curriculum included treating complex cases. Most deans stated that dual‐specialty training in prosthodontics and periodontics would be beneficial. The 2009 survey reported an increase in the number of departments of prosthodontics in US schools.
Comprehensive analysis of RHD alleles in Argentineans with variant D phenotypes
Authors: Brajovich Melina E. Luján , Trucco Boggione Carolina , Biondi Claudia S. , Racca Amelia L. , Tarragó Marcel , Nogués Núria , Muñiz‐Díaz Eduardo , Cotorruelo Carlos M. 
Published: September 2011

BACKGROUND: The serologic assignment of the RhD status may be hindered in patients with weak D expression. A comprehensive study of RHD alleles occurring in the mixed population of Argentina is necessary to evaluate the most suitable DNA typing strategy.STUDY DESIGN AND METHODS: A total of 18,379 patients from two stratified groups, Group 1 (G1; public hospital) and Group 2 (G2; private laboratory), were RhD phenotyped, and 88 samples with reduced D expression underwent molecular characterization.RESULTS: The frequencies of D+, D–, and variant D phenotypes differed significantly (p < 0.001) between G1 and G2 (94.49% vs. 87.66%, 5.15% vs. 11.58%, and 0.36% vs. 0.75%, respectively). Eleven alleles were responsible for the weak D expression. Approximately 60% of the variant D phenotypes from G1 and G2 were weak D Types 1 through 4.0/4.2 and 25% were DVII. RHD alleles associated with African ancestry were encountered in G1. A new −282G>A mutation within the promoter region of DAU‐4 and DOL alleles was identified. Three weak D Type 1 samples on R0 haplotypes were found in G1.CONCLUSIONS: The D phenotype distribution in G2 resembles that in Europeans while the frequencies in G1 account for the Amerindian and African genetic contribution. The genotyping strategy described here is suitable to study D variants in the overall population and could allow a better use of the few available D– units and a rational administration of anti‐D immunoprophylaxis. The results also show that weak D Type 1 alleles do not exclusively segregate with a Ce allele, as assumed until present.
Changes in coagulation factor activity and content of di(2‐ethylhexyl)phthalate in frozen plasma units during refrigerated storage for up to five days after thawing
Authors: Sheffield William P. , Bhakta Varsha , Mastronardi Cherie , Ramirez‐Arcos Sandra , Howe David , Jenkins Craig 
Published: September 2011

BACKGROUND: Thawed plasma is typically transfused to supply coagulation factors but factor activity declines during refrigerated storage. Refrigerating thawed plasma for longer than 24 hours could reduce plasma wastage and make plasma more readily available for emergency transfusions. We measured coagulation factor activity and di(2‐ethylhexyl)phthalate (DEHP) concentration in frozen plasma (FP) thawed and stored at 1 to 6°C for up to 5 days.STUDY DESIGN AND METHODS: FP units prepared using “top‐and‐bottom” collection sets were thawed, refrigerated, and sampled aseptically at 0, 24, 72, and 120 hours after thawing (n = 54). Clotting factor activities and prothrombin times (PTs) were measured using an automated coagulation factor analyzer. DEHP was measured by high‐performance liquid chromatography after hexane extraction (n = 11). Unit sterility was confirmed using an automated microbial detection system.RESULTS: Factor (F)V and FVIII, but not FVII, declined significantly within 24 hours. By Day 5, mean losses were 20, 14, and 41%, in FV, FVII, and FVIII, respectively; fibrinogen activity did not change. PT values were prolonged by 9% on Day 5. Mean DEHP levels increased from 22 ppm at thaw to 66 ppm on Day 5.CONCLUSIONS: The bulk of coagulation factor activity losses during storage occurred in the first 24 hours. Coagulation factor activities remaining in FP after 5 days did not differ from those previously reported in similar products frozen within 24 hours of phlebotomy. While DEHP levels in 5‐day‐thawed FP are not of concern for adult patients, for infants, DEHP levels can be minimized by using FP refrigerated for no more than 24 hours.
Allergic agonists in apheresis platelet products are associated with allergic transfusion reactions
Authors: Savage William J. , Savage Jessica H. , Tobian Aaron A.R. , Thoburn Chris , Hamilton Robert G. , Schroeder John T. , Ness Paul M. 
Published: September 2011

BACKGROUND: The mechanisms that underlie allergic transfusion reactions (ATRs) are not well characterized, but likely involve recipient, donor, and product factors. To assess product factors associated with ATRs, we investigated candidate mediators in apheresis platelet (PLT) products associated with ATRs and controls.STUDY DESIGN AND METHODS: Using bead‐based and standard enzyme‐linked immunosorbent assays, we tested supernatants from 20 consecutive apheresis PLT transfusions associated with ATRs and 30 control products for concentrations of mediators in three categories: acute inflammatory mediators, direct agonists of basophils and mast cells, and growth and/or priming factors of basophils and mast cells.RESULTS: Median concentrations of the direct allergic agonists C5a, brain‐derived neurotrophic factor (BDNF), and CCL5 (RANTES) were 16.6, 41.8, and 13.9% higher, respectively, in the supernatant of apheresis PLT products that were most strongly associated with ATRs (p < 0.05 for each mediator). Other direct agonists (macrophage inflammatory protein‐1α, monocyte chemotactic protein‐1, eotaxin‐1, interleukin‐8) were similar between groups. Concentrations of acute inflammatory mediators and basophil growth and/or priming factors were also similar between groups (p > 0.2 for all associations).CONCLUSION: The allergic agonists C5a, BDNF, and CCL5 may be mediators of ATRs in apheresis PLT products. Acute inflammatory proteins and basophil and/or mast cell growth and priming factors do not appear to be associated with apheresis PLT products that cause ATRs.
Red blood cell transfusions and tissue oxygenation in anemic hematology outpatients
Authors: Yuruk Koray , Bartels Sebastiaan A. , Milstein Dan M.J. , Bezemer Rick , Biemond Bart J. , Ince Can 
Published: September 2011

BACKGROUND: There is little clinical evidence that red blood cell (RBC) transfusions improve oxygen availability at the microcirculatory level. We tested the hypotheses that anemia in chronically anemic patients with relatively healthy microcirculation would be associated with low tissue hemoglobin (Hb) and tissue oxygenation levels and that these conditions would be improved after RBC transfusions.STUDY DESIGN AND METHODS: Near‐infrared spectroscopy (NIRS) was used to determine tissue oxygen saturation (StO2) and tissue Hb index (THI; an index of the amount of Hb in the NIRS measurement volume) in the thenar eminence and sublingual tissue before and 30 minutes after RBC transfusions in 20 chronically anemic hematology outpatients. Data are presented as median (25%‐75%).RESULTS: The patients received three (two to three) bags of RBCs in saline‐adenine‐glucose‐mannitol with an age of 21 (7‐21) days, which was infused intravenously at the rate of 0.7 bag/hr. RBC transfusions significantly increased hematocrit level from 26% (24%‐28%) to 32% (30%‐34%; p < 0.0001), Hb level from 8.2 (7.6‐8.9) g/dL to 11.0 (9.9‐11.8) g/dL (p < 0.0001), whole blood viscosity from 3.4 (3.1‐3.5) mPa/sec to 4.2 (4.0‐4.5) mPa/sec (p < 0.0001), thenar StO2 from 81% (80%‐84%) to 86% (81%‐89%; p = 0.002), thenar THI from 11.2 (9.3‐13.3) AU to 13.7 (9.7‐15.3) AU (p = 0.024), sublingual StO2 from 86% (81%‐89%) to 91% (86%‐92%; p < 0.0001), and sublingual THI from 15.2 (13.0‐17.4) AU to 17.2 (13.5‐19.7) AU (p = 0.040).CONCLUSION: Although anemia in chronically anemic hematology outpatients was not associated with low StO2 and THI levels, RBC transfusions were successful in improving these variables.
Cost‐effectiveness of additional blood screening tests in the Netherlands
Authors: Borkent‐Raven Barbara A. , Janssen Mart P. , van der Poel Cees L. , Bonsel Gouke J. , van Hout Ben A. 
Published: September 2011

BACKGROUND: During the past decade, blood screening tests such as triplex nucleic acid amplification testing (NAT) and human T‐cell lymphotropic virus type I or I (HTLV‐I/II) antibody testing were added to existing serologic testing for hepatitis B virus (HBV), human immunodeficiency virus (HIV), and hepatitis C virus (HCV). In some low‐prevalence regions these additional tests yielded disputable benefits that can be valuated by cost‐effectiveness analyses (CEAs). CEAs are used to support decision making on implementation of medical technology. We present CEAs of selected additional screening tests that are not uniformly implemented in the EU.STUDY DESIGN AND METHODS: Cost‐effectiveness was analyzed of: 1) HBV, HCV, and HIV triplex NAT in addition to serologic testing; 2) HTLV‐I/II antibody test for all donors, for first‐time donors only, and for pediatric recipients only; and 3) hepatitis A virus (HAV) for all donations. Disease progression of the studied viral infections was described in five Markov models.RESULTS: In the Netherlands, the incremental cost‐effectiveness ratio (ICER) of triplex NAT is €5.20 million per quality‐adjusted life‐year (QALY) for testing minipools of six donation samples and €4.65 million/QALY for individual donation testing. The ICER for anti‐HTLV‐I/II is €45.2 million/QALY if testing all donations, €2.23 million/QALY if testing new donors only, and €27.0 million/QALY if testing blood products for pediatric patients only. The ICER of HAV NAT is €18.6 million/QALY.CONCLUSION: The resulting ICERs are very high, especially when compared to other health care interventions. Nevertheless, these screening tests are implemented in the Netherlands and elsewhere. Policy makers should reflect more explicit on the acceptability of costs and effects whenever additional blood screening tests are implemented.
Comparison of the in vitro storage properties of Amicus apheresis platelets collected using single‐ and double‐needle procedures from the same donors
Authors: Wagner Stephen J. , Seetharaman Shalini , Kurtz James 
Published: September 2011

BACKGROUND: Amicus apheresis platelets (PLTs) can be collected using either a single‐ (SN) or a double‐needle (DN) procedure. To investigate whether the method of PLT collection using the same instrument influences PLT quality, the in vitro storage properties of Amicus PLTs were evaluated in the same donors collected by SN and DN procedures.STUDY DESIGN AND METHODS: Single apheresis PLT collections with concurrent plasma were performed on donors using the Amicus with a target yield of 4 × 1011. A PLT unit was collected from a donor assigned to either a SN or a DN procedure; a subsequent donation from the same individual was collected by the other procedure (n = 10). Units were stored at 20 to 24°C with continuous agitation, assayed for 19 PLT storage variables, and analyzed by paired t test, with differences between values obtained with SN and DN collections considered significant with p values of less than 0.001.RESULTS: PLT units collected by SN procedure had contents and concentrations similar to those collected by DN procedures (4.1 × 1011 ± 0.3 × 1011 vs. 4.0 × 1011 ± 0.3 × 1011 and 1396 × 109 ± 131 × 109 vs. 1367 × 109 ± 110 × 109 PLTs/L). On Day 7, SN and DN PLTs had comparable pH values (7.07 ± 0.09 vs. 6.99 ± 0.17), morphology (52.4 ± 18.7% vs. 56.0 ± 13.3% discoid), aggregation (87.1 ± 11.5% vs. 91.3 ± 5.4%), and activation (45.8 ± 11.9% vs. 48.2 ± 8.7% CD62P), as well as all other variables (p > 0.05; Day 7 CO2, p = 0.0304).CONCLUSION: The in vitro storage properties of apheresis PLTs collected from the same donors using a SN and DN procedure with the Amicus instrument were maintained through 7 days of storage and yielded comparable results.
High‐Temperature Electrical Conductivity Measurements on Nanostructured Yttria‐Doped Ceria Thin Films in Ozone
Authors: Abazari Maryam , Tsuchiya Masaru , Ramanathan Shriram 
Published: September 2011

We have investigated how ozone affects high‐temperature electrical properties of nanostructured yttria‐doped ceria (YDC) thin films using impedance spectroscopy. It is found that predominantly ionic conductivity in the doped‐ceria lattice is not altered upon exposure to ozone. The grain boundaries in YDC ultra‐thin films, in contrast, exhibited a substantial increase in resistance in ozone‐rich environment. While activation energy for lattice conduction in ozone was similar to air, being close to 1 eV, grain boundary activation energy increased notably from ~1.3 eV in air to 1.7 eV in ozone. Also, we have investigated kinetics of resistance change in such thin films in air and in ozone ambient using galvanostatic measurements and found that the rapid resistance change observed in ozone was reversible. Mechanisms leading to the observation and implications for ozone‐ceria film surface interactions are discussed.
New Low‐Loss Microwave Dielectric Material ZnTiNbTaO8
Authors: Liao Qingwei , Li Lingxia , Ren Xiang , Ding Xiang 
Published: September 2011

A new low‐loss, low‐temperature sinterable microwave dielectric material ZnTiNbTaO8 was investigated for the first time. Single phase ZnTiNbTaO8 was obtained by the conventional solid‐state route and sintered at 1120°C–1200°C for 6 h. Theoretical density, packing fraction, bond valence, and oxygen octahedron distortion were calculated. The excellent microwave dielectric properties of ε = 36.3, Qf = 67 000 GHz, τf =−57.66 × 10−6/°C were obtained from the new ZnTiNbTaO8 materials sintered at 1140°C for 6 h.
Gliosarcoma Metastatic to the Leptomeninges and Dura
Authors: Mansouri Bobbak , Barboriak Daniel P. , Kilani Ramsey K. 
Published: September 2011

ABSTRACTWe describe a rare case of a patient with left frontotemporal gliosarcoma, which metastasized through the cerebrospinal fluid (CSF) to the leptomeninges and pachymeninges. Pathologically confirmed, magnetic resonance imaging‐visible leptomeningeal spread of gliosarcoma via the CSF has not been previously reported.