bluuebunny/crossref_metadata_2025_split huggingface dataset:
ChemInform Abstract: Synthesis of Highly Functionalized Biaryls by Condensation of 2‐Fluoro‐1,3‐bis(silyloxy) 1,3‐Dienes with 3‐Cyanochromones and Subsequent Domino “Retro‐Michael/Aldol/Fragmentation”.
Authors: Ibad Muhammad Farooq , Abid Obaid‐ur‐Rahman , Adeel Muhammad , Nawaz Muhammad , Wolf Verena , Villinger Alexander , Langer Peter 
Published: February 2011

AbstractTmsOTf‐mediated coupling is followed by treatment with NEt3 to provide azaxanthones and/or highly functionalized biaryls depending on the diene structure.
ChemInform Abstract: Suzuki—Miyaura and Hiyama Reactions Catalyzed by Orthopalladated Triarylphosphite Complexes.
Authors: Blaszczyk Izabela , Trzeciak Anna M. 
Published: February 2011

AbstractThe synthesis of biaryl (IIIa) is examined by application of 11 palladium complexes bearing triphenylphosphito ligands in both C—C coupling methods.
ChemInform Abstract: Synthesis of Fe3O4 Microspheres‐Supported Catalysts for Suzuki Coupling Reaction.
Authors: Zhang Yanqi , Wei Xianwen , Yao Zijian 
Published: February 2011

AbstractAmong a variety of title catalysts the Fe3O4—G4—polyaminoamido (PAMAM) dendrimers—Pd(0) catalyst is found to be the most efficient for the Suzuki coupling reaction.
ChemInform Abstract: Synthesis of Chalcones and Flavanones Using Julia—Kocienski Olefination.
Authors: Kumar Atul , Sharma Siddharth , Tripathi Vishwa Deepak , Srivastava Suman 
Published: February 2011

AbstractArylethanones of type (I) and (IV) are applied as Julia coupling partners for the reaction with aromatic aldehydes to give chalcones and flavanones, correspondingly.
ChemInform Abstract: Efficient Synthesis of 2,2‐Diaryl‐1,1‐difluoroethenes via Consecutive Cross‐Coupling Reactions of 2,2‐Difluoro‐1‐tributylstannylethenyl p‐Toluenesulfonate.
Authors: Han Seung Yeon , Jeong In Howa 
Published: February 2011

AbstractThe method applies aryl iodides and aryl stannanes as cross‐coupling partners for the consecutive arylation of the stannyl and tosylate functionalities concerning the starting (I).
ChemInform Abstract: Microwave‐Assisted, Pd(0)‐Catalyzed Cross‐Coupling of Diazirines with Aryl Halides.
Authors: Zhao Xia , Wu Guojiao , Yan Chong , Lu Kui , Li Hui , Zhang Yan , Wang Jianbo 
Published: February 2011

AbstractA variety of di‐, tri‐ and tetrasubstituted alkenes is prepared from the diazirines and aryl bromides and many functional groups are tolerated.
ChemInform Abstract: Chiral Ruthenium Lewis Acid Catalyzed Intramolecular Diels—Alder Reactions.
Authors: Thamapipol Sirinporn , Bernardinelli Gerald , Besnard Celine , Kuendig E. Peter 
Published: February 2011

AbstractThe endo cycloaddition isomers arise as major products with excellent yields and high enantioselectivities.
ChemInform Abstract: Asymmetric Epoxidation of α‐Substituted Acroleins Catalyzed by Diphenylprolinol Silyl Ether.
Authors: Bondzic Bojan P. , Urushima Tatsuya , Ishikawa Hayato , Hayashi Yujiro 
Published: February 2011

AbstractThe method applies a secondary amine catalyst PSE for this type of reaction and generates a chiral quaternary center with high enantioselectivity.
ChemInform Abstract: Indium‐Promoted Chemo‐ and Diastereoselective Allylation of α,β‐Epoxy Ketones with Potassium Allyltrifluoroborate.
Authors: Nowrouzi Farhad , Janetzko John , Batey Robert A. 
Published: February 2011

AbstractThe regioselective reaction requires a stoichiometric amount of In to achieve high yields and diastereoselectivity and the ratio CH2Cl2/H2O plays a significant role.
ChemInform Abstract: 3‐Alkoxy‐2,5‐dihydrofurans by Gold‐Catalyzed Allenyl Cyclizations and Their Transformation into 1,4‐Dicarbonyl Compounds, Cyclopentenones, and Butenolides.
Authors: Brasholz Malte , Dugovic Branislav , Reissig Hans‐Ulrich 
Published: February 2011

AbstractA variety of 3‐alkoxydihydrofurans including optically active derivatives are synthesized by Au‐catalyzed cyclization reaction of appropriate allenyl alcohols derived from alkoxyallenes (I).
ChemInform Abstract: SmI2‐Mediated Radical Cyclizations Directed by a C—Si Bond.
Authors: Harb Hassan Y. , Collins Karl D. , Altur Jose V. Garcia , Bowker Sue , Campbell Leonie , Procter David J. 
Published: February 2011

AbstractThe silicon substituent, connected to carbon, plays a crucial role as controlling element to achieve the diastereoselective cyclization with formation of 2 or 3 stereocenters.
ChemInform Abstract: Di‐ and Trisubstituted γ‐Lactams via Rh(II)‐Carbenoid Reaction of N‐Cα‐Branched, N‐Bis(trimethylsilyl)methyl α‐Diazoamides. Synthesis of (.+‐.)‐α‐Allokainic Acid.
Authors: Zhang Bao , Wee Andrew G. H. 
Published: February 2011

AbstractThe N‐protecting group and the O‐pivaloyl moiety play a crucial role for achieving the regio‐, chemo‐ and diastereoselective preparation of highly substituted γ‐lactams.
ChemInform Abstract: Efficient Strategy for the Synthesis of 4‐Hydroxy‐1H‐pyrrole‐2,3‐dicarboxylic Ester Derivatives Using Transition‐Metal‐Oxide Catalysts.
Authors: Paul V. Luke , Yakaiah T. , Reddy A. Raghuram , Shekhar A. Chandra , Rao P. Shanthan , Narsaiah B. 
Published: February 2011

AbstractFor the presented facile synthesis of the compounds (III) CAN and EDC can also be used as catalysts but this results in lower yields.
ChemInform Abstract: Organocatalytic Asymmetric Synthesis of Substituted 3‐Hydroxy‐2‐oxindoles via Morita—Baylis—Hillman Reaction.
Authors: Liu yun‐Lin , Wang Bo‐Lun , Cao Jun‐Jie , Chen Long , Zhang Yong‐Xue , Wang Chao , Zhou Jian 
Published: February 2011

AbstractTarget compounds (III), substructures in natural product and drug synthesis, are available in a highly stereoselective manner.
ChemInform Abstract: Pd‐NHC Catalyzed Cyclopentannulation of Diazabicyclic Alkenes with ortho‐Aryl Halides.
Authors: Prasad B. A. Bhanu , Buechele Alexander E. , Gilbertson Scott R. 
Published: February 2011

AbstractThe reaction proceeds under microwave‐assisted conditions with complete diastereoselectivity.
ChemInform Abstract: New Chiral Ferrocenyl P,S‐Ligands for Highly Diastereo‐/Enantioselective Catalytic [3 + 2] Cycloaddition of Azomethine Ylides with Cyclic and Acyclic Enones.
Authors: Zhang Cheng , Yu Sai‐Bo , Hu Xiang‐Ping , Wang Dao‐Yong , Zheng Zhuo 
Published: February 2011

AbstractThe cyclic enones (I) and (VI) react with a variety of aromatic azomethine ylides under conditions A) to give exclusively endo‐cycloadducts with excellent enantioselectivities.
ChemInform Abstract: Synthesis of 5,7‐Dibromotropono[c]pyrazole Derivatives.
Authors: Li Yang , Gao Wentao 
Published: February 2011

AbstractCondensation of tropolone derivatives (I) with aromatic hydrazines (II) afford the troponopyrazoles (III) in good yields.The electronic nature of the substituents has no significant effect on the reactions.
ChemInform Abstract: TBHP/I2‐Mediated Domino Oxidative Cyclization for One‐Pot Synthesis of Polysubstituted Oxazoles.
Authors: Jiang Huanfeng , Huang Huawen , Cao Hua , Qi Chaorong 
Published: February 2011

AbstractThe addition of excess amine in 2 portions is crucial to avoid its oxidation to the aldehyde.
ChemInform Abstract: A Novel Aminothiazole Derivative Induces Apoptosis and Cell Cycle Arrest in Tumor Cells.
Authors: Li Minghua , Oh Changwon , Park Jun Seok , Ham Seung Wook 
Published: February 2011

AbstractCompound (I), found in a cell‐based high‐throughput screening, exhibits significant cell growth inhibition against HepG2 cells.
ChemInform Abstract: Synthesis of Some Fused Triazole Derivatives Containing 4‐Isobutylphenylethyl and 4‐Methylthiophenyl Moieties.
Authors: Kumsi Manjunatha , Poojary Boja , Lobo Prajwal L. , Fernandes Jennifer , Chikkanna Chandrashekhar 
Published: February 2011

AbstractNovel fused heterocycles (III) are obtained by condensing triazoles with various N‐arylmaleimides in acetic acid media.
ChemInform Abstract: Gold(I)‐Catalyzed Cycloisomerization of β‐Alkynylpropiolactones to Substituted α‐Pyrones.
Authors: Dombray Thomas , Blanc Aurelien , Weibel Jean‐Marc , Pale Patrick 
Published: February 2011

AbstractLarge groups and an ether functionality at the alkyne moiety reduce the reactivity and the yields of the resulting pyrones.
ChemInform Abstract: InIII‐Catalyzed Tandem C—C and C—O Bond Formation Between Phenols and Allylic Acetates.
Authors: Vece Vito , Ricci Jeremy , Poulain‐Martini Sophie , Nava Paola , Carissan Yannick , Humbel Stephane , Dunach Elisabet 
Published: February 2011

AbstractThe one‐pot reaction constitutes an attractive alternative for the construction of O‐heterocyclic compounds like vitamin E (XI).
ChemInform Abstract: Palladium‐Catalyzed [3 + 2 + 1] Cyclocarbonylative Coupling of 1,3‐Cyclohexanediones, Alkynes, and Carbon Monoxide: An Atom‐Economic Route to Chromene Route to Chromene‐2,5‐dione Derivatives.
Authors: Wu Bei , Hua Ruimao 
Published: February 2011

AbstractVarious target compounds are available with aromatic alkynes.
ChemInform Abstract: Ytterbium(III) Bis(perfluorooctanesulfonyl)imide Catalyzed One‐Pot Synthesis of Tetrahydrobenzo[b]pyrans in Fluorous Biphase System.
Authors: Hong Mei , Cai Chun 
Published: February 2011

AbstractAn efficient synthesis of 4H‐benzo[b]pyran derivatives (IV) (16 examples) by Yb‐catalyzed one‐pot three‐component condensation of aldehydes, active methylene compounds, and dimedone in a fluorous biphase system is presented.
ChemInform Abstract: 5‐Hydroxychromone, an Alternative Scaffold for anti‐HCV 1,3‐Diketo Acid (DKA).
Authors: Lee Chaewoon , Park Kwang‐su , Park Hye Ri Park Hye Ri , Ppark Jun Cheol Ppark Jun Cheol , Lee Bokhui , Kim Dong‐Eun , Chong Youhoon 
Published: February 2011

AbstractNovel chromone derivatives of type (I) are prepared.
ChemInform Abstract: Synthesis of 3‐S‐Hetaryl‐Substituted Pyridin‐2(1H)‐ones and 5,6‐Dihydropyridin‐2(1H)‐ones
Authors: Fisyuk A. S. , Bogza Y. P. , Poendaev N. V. , Goncharov D. S. 
Published: February 2011

Abstractvia base‐mediated cyclization of corresponding N‐(3‐oxoalkenyl)‐ or N‐(3‐oxoalkyl)amides (III) and (VI), respectively
ChemInform Abstract: Synthesis of 3‐Substituted Derivatives of 2,2,6,6‐Tetramethylpiperidine‐N‐alkoxyamine Ethers: Novel Alkoxyamine Building Blocks.
Authors: Fischer Walter , Basbas Abdel‐Ilah , Schoening Kai‐Uwe , Hauck Stefan 
Published: February 2011

AbstractNovel enamines of alkoxyamines are prepared starting with the O‐alkylation of 4‐oxo‐tetramethylpiperidinyloxyl.
ChemInform Abstract: Asymmetric Synthesis of 2‐Aryl‐2,3‐dihydro‐4‐quinolones via Bifunctional Thiourea‐Mediated Intramolecular Cyclization.
Authors: Liu Xiaoqian , Lu Yixin 
Published: February 2011

AbstractThe presence of the N‐tosyl group is crucial to achieve high enantioselectivity.
ChemInform Abstract: One‐Pot Synthesis of Hexahydroquinolines via Hantzsch Four‐Component Reaction Catalyzed by a Cheap Amino Alcohol.
Authors: Song Shao‐Jun , Shan Zi‐Xing , Jin Yong 
Published: February 2011

AbstractThe advantages of the presented method are the simple experimental procedure, mild conditions, lowcost, and excellent yields.
ChemInform Abstract: Platinum(II)‐Catalyzed Intramolecular Cyclization of Alkynylbenzonitriles: Synthesis of 1‐Alkoxyisoquinolines and Isoquinolones.
Authors: Li Jim , Chen Lijing , Chin Elbert , Lui Alfred S. , Zecic Hasim 
Published: February 2011

Abstract1‐Alkoxyisoquinolines as major products can be easily converted into isoquinolines by dealkylation with HBr in acetic acid.
ChemInform Abstract: Regioselectivity in Direct Arylation of Benzanilide Possessing Oxygen Substituent in the Benzoyl Part Using Palladium Without Phosphine Ligand.
Authors: Harayama Takashi , Nagura Chie , Miyagoe Taeko , Kawata Yuko , Abe Hitoshi , Takeuchi Yasuo 
Published: February 2011

AbstractThe arylation of benzanilide (I) possessing ether oxygen(s) proceeds under phosphine‐ligand free conditions to afford the para‐product (II) and the ortho‐product (III) in a similar ratio as in the presence of the P(o‐Tol)3 ligand, suggesting that the bulkiness of palladium under phosphine‐free conditions is comparable to that under P(o‐Tol)3 conditions.
ChemInform Abstract: Synthesis and Alkylation of 4‐Aryl‐5‐oxo‐1H‐2,3,4,5‐tetrahydroindeno[1,2‐b]pyridines.
Authors: Stupnikova S. , Petushkova E. , Tanajev D. , Lusis V. , Muceniece D. 
Published: February 2011

AbstractReduction of dihydroindenopyridines (I) or (VIII) with Et3SiH in TFA affords corresponding trans‐tetrahydroindenopyridines (II) and (VI), resp., as the major products.
ChemInform Abstract: Three‐Component Solvent‐Free Synthesis of Highly Substituted Bicyclic Pyridines Containing a Ring‐Junction Nitrogen.
Authors: Yan Shengjiao , Chen Yulan , Liu Lin , He Nengqin , Lin Jun 
Published: February 2011

AbstractA series of bicyclic pyridines (IV), (VI), (VIII), and (X) is readily prepared by a three component reaction of heterocyclic ketene aminals such as (I) and (IX) with active methylene compounds and triethyl orthoformate under solvent‐free conditions.
ChemInform Abstract: A Versatile Synthesis of 3‐Substituted 4‐Cyano‐1,2,3,4‐tetrahydro‐1‐oxo‐β‐carbolines.
Authors: Huber Kilian , Kast Oliver , Bracher Franz 
Published: February 2011

AbstractCondensation of indole derivatives (I) with various carbonyl compounds and ammonia gives the title compounds in moderate to good yields.
ChemInform Abstract: Facile Three‐Component Domino Reactions in the Regioselective Synthesis and Antimycobacterial Evaluation of Novel Indolizines and Pyrrolo[2,1‐a]isoquinolines.
Authors: Muthusaravanan Sivasubramanian , Perumal Subbu , Yogeeswari Perumal , Sriram Dharmarajan 
Published: February 2011

AbstractThe products exhibit activities which are comparable or even better than those of the standard agents ethambutol and ciprofloxacin.
ChemInform Abstract: Biginelli Reaction Starting Directly from Alcohols.
Authors: Garima Garima , Srivastava Vishnu P. , Yadav Lal Dhar S. 
Published: February 2011

AbstractThe efficient one‐pot proceeds via [hmim]HSO4‐catalyzed oxidation of the alcohols with NaNO3 to aldehydes followed by cyclocondensation with urea and carbonyl compounds (14 examples).
ChemInform Abstract: Synthesis of 2‐Oxo/Thioxooctahydroquinazolin‐5‐one Derivatives and Their Evaluation as Anticancer Agents.
Authors: Kidwai Mazaahir , Bhatnagar Divya , Kumar Rakesh , Luthra Pratibha Mehta 
Published: February 2011

AbstractTitle compounds (IV) and (VII) are prepared using a CAN‐catalyzed Biginelli reaction in PEG as solvent.
ChemInform Abstract: Selective Synthesis of 7‐Substituted Purines via 7,8‐Dihydropurines.
Authors: Kotek Vladislav , Chudikova Nadezda , Tobrman Tomas , Dvorak Dalimil 
Published: February 2011

AbstractThe one‐pot procedure starting from halopurines (I) or (VI) involves only two separation steps.
ChemInform Abstract: Cross‐Coupling Reaction on N‐(3,5‐Dibromo‐2‐pyridyl)piperazines: Regioselective Synthesis of 3,5‐Disubstituted Pyridylpiperazines.
Authors: Hikawa Hidemasa , Yokoyama Yuusaku 
Published: February 2011

AbstractStarting from tribromopyridine, the title compounds are prepared by regioselective amination yielding dibromopyridines (I), followed by successive coupling.
ChemInform Abstract: A Novel 3‐Phenylethynyl‐2‐yl‐oxy Quinoxaline Core Skeleton and Pharmacophore Model as a Hypoxia‐Inducible Factor Inhibitor.
Authors: Gong Young‐Dae , Kang Nam Sook 
Published: February 2011

AbstractCompound (I) is prepared in a five‐step procedure as model for novel HIF‐1α inhibitors.
ChemInform Abstract: Alkylations of 10H‐2,7‐Diazaphenothiazine to Alkyl‐2,7‐diazaphenothiazinium Salts and 7‐Alkyl‐2,7‐diazaphenothiazines.
Authors: Morak‐Mlodawska Beata , Pluta Krystian , Suwinska Kinga , Jelen Malgorzata 
Published: February 2011

AbstractProlonging the reaction time from 24 to 72 hours the methylation of diazaphenothiazine (I) occurs both at the thiazine and the pyridine nitrogen atom, cf.
ChemInform Abstract: Cyclotrimerization of 3‐R‐1,2,4‐Triazin‐5(4H)‐ones with Cyclic Ketones.
Authors: Egorov Ilya N. , Kovalev Igor S. , Rusinov Vladimir L. , Chupakhin Oleg N. 
Published: February 2011

AbstractNovel zwitterionic tetracyclic heterocycles (III) are synthesized.
ChemInform Abstract: Intramolecular Cyclization of Mannich Reaction for Synthesis of Pyrimido[2,1‐b]‐1,3,5‐thiadiazines.
Authors: El‐Sherief Hassan A. H. , Hozien Zeinab A. , El‐Mahdy Ahmed F. M. , Sarhan Abdelwarth A. O. 
Published: February 2011

AbstractReaction of 2‐mercaptodihydropyrimidinones (I) with primary amines and formaldehyde in suitable solvent yields pyrimidothiadizinones (IV) (35 examples) via a double Mannich reaction.
ChemInform Abstract: Design and Synthesis of Novel Retinoid Synergists Having a Dibenzodiazepine Skeleton.
Authors: Ohta Kiminori , Kawachi Emiko , Shudo Koichi , Kagechika Hiroyuki 
Published: February 2011

AbstractBased on the structures of two potent retinoid X receptor agonists, the novel dibenzodiazepine derivatives (VI), (VIII), and (XIII), containing two diphenylamine substructures, are designed as retinoid X receptor modulator candidates and prepared by means of Pd‐catalyzed, cf.
ChemInform Abstract: Gold(III)‐Catalyzed Halogenation of Aromatic Boronates with N‐Halosuccinimides.
Authors: Qiu Di , Mo Fanyang , Zheng Zhitong , Zhang Yan , Wang Jianbo 
Published: February 2011

AbstractA wide range of target compounds is generated mostly regioselectively using halogen succinimides.
ChemInform Abstract: Enantioselective Rh‐Catalyzed Hydrogenation of 3‐Aryl‐4‐phosphonobutenoates with a P‐Stereogenic BoPhoz‐Type Ligand.
Authors: Duan Zheng‐Chao , Hu Xiang‐Ping , Zhang Cheng , Zheng Zhuo 
Published: February 2011

AbstractThe method allows an efficient and highly enantioselective access to phosphonates of type (II) and can be applied to prepare the potential GABAB antagonist (R)‐phaclofen (V).
ChemInform Abstract: Preparation of Red Dyes Derived from Diketo‐pyrrolo‐pyrrole Based Pigment and Their Properties for LCD Color Filters.
Authors: Choi Se‐Hwa , Kil Ga‐hye , Kim Na‐rim , Yoon Chun , Kim Jae‐Pil , Choi Jae‐Hong 
Published: February 2011

AbstractRed DPP pigments (I) are prepared as an alternative to increase the contrast ratio and brightness which are crucial requirements in LCD color filter sector.
ChemInform Abstract: Vernodalidimers A and B, Novel Orthoester Elemanolide Dimers from Seeds of Vernonia anthelmintica.
Authors: Liu Yongqiang , Nugroho Alfarius E. , Hirasawa Yusuke , Nakata Asami , Kaneda Toshio , Uchiyama Nahoko , Goda Yukihiro , Shirota Osamu , Morita Hiroshi , Aisa Haji Akber 
Published: February 2011

AbstractPreliminary studies reveal potent cell growth inhibition for HL‐60 cells.
ChemInform Abstract: Synthesis of Hydroxymethyl Side‐Chained α‐Aminoxy Diamide.
Authors: Luo Zheng , Yang Hai‐Feng , Chang Xiao‐Wei , Zhang Dan‐Wei 
Published: February 2011

AbstractAn α‐aminooxy monomer with polar hydroxymethyl side chain (X) is synthesized from L‐serine in 15% overall yield.
ChemInform Abstract: Inhibitory Activities of Kojyl Thioether Derivatives Against Nitric Oxide Production Induced by Lipopolysaccharide.
Authors: Rho Ho Sik , Yoo Dae Sung , Ahn Soo Mi , Kim Myung Kyoo , Cho Dong Ha , Cho Jae Youl 
Published: February 2011

AbstractA series of kojic acid thioether derivatives (I), their sulfoxides (II), and sulfones (III) are synthesized and evaluated for inhibitory activity against NO production in LPS‐activated macrophages.
ChemInform Abstract: Antihypertensive Effects of 5‐(4‐Nitrobenzenediazo)‐8‐benzenesulfonamidoquinaldine in Spontaneously Hypertensive Rats.
Authors: Hong Jang Hee , Lee Sung , Jung Hyo Sung , Lee Kyung Bok , Kim Jong Seung 
Published: February 2011

AbstractThe title compound (I) is a selective and sensitive Zn2+‐ion chelating agent.
ChemInform Abstract: Development of Samarium Diiodide Promoted Regioselective Carbon—Carbon Bond Cleavage Reaction of γ‐Halo‐ and ε‐Halo‐α,β‐Unsaturated Carbonyl Compounds: Application to the Synthesis of Biologically Active Natural Products
Authors: Honda Toshio 
Published: February 2011

AbstractReview: 61 refs.
Strength and Operating Properties of Wave‐Ring Gaskets
Authors: Trojnacki Andrzej 
Published: February 2011

AbstractIn der vorliegenden Arbeit werden die Ergebnisse einer Analyse von Festigkeits‐ und Betriebseigenschaften von Doppelwellendichtungen dargestellt. Zur Analyse wurde die Dichtung mit einer rotationssymmetrischen Zylinderschale einer gemittelten Dicke modelliert, mit einem Ringauflager an der inneren Oberfläche des dickwandigen Zylinders, der den Verbindungssitz simuliert. Es wurde der Einfluss von bestimmten geometrischen, Material‐ und Montageparametern der Dichtung auf ihre Festigkeit sowie hinsichtlich der Dichtheit der Verbindung untersucht. Die Analyseergebnisse wurden mit einem numerischen Beispiel veranschaulicht, in dem für ein bestimmtes Dichtungsmaterial und für gewisse Abmessungen der zulässige Bereich von Lösungen für weitere Parameter wie Abmessung, Montageübermaß und Druck bestimmt wurde.
Advanced Processes for Better Materials – Tape Casting from Nanoparticles
Authors: Knieke Catharina , Peukert Wolfgang , Vozdecky Pavel , Roosen Andreas 
Published: February 2011

AbstractAm Beispiel der Herstellung keramischer Folien wird gezeigt, wie verfahrenstechnische Fortschritte zu verbesserten Werkstoffeigenschaften führen. Ein wesentlicher verfahrenstechnischer Fortschritt ist die Möglichkeit, Nanopartikel durch Echtzerkleinerung in Rührwerkskugelmühlen in hoher Ausbeute herzustellen. Die nanoskaligen Suspensionen können direkt zu keramischen Folien verarbeitet werden. Die Verarbeitung der Nanopartikel erfordert eine Anpassung der bestehenden Prozessbedingungen und führt zu deutlichen Eigenschaftsverbesserungen der daraus hergestellten Werkstoffe hinsichtlich Gefügestruktur, Oberflächenrauhigkeit, Festigkeit und optischer Transparenz.
Investigation of Water Adsorption of Crystalline Fertilizer
Authors: Rößler Michael , Stelzer Torsten , Ulrich Joachim 
Published: February 2011

AbstractNeben der gewünschten Düngerwirkung ist die Lagerstabilität eine sehr wichtige Eigenschaft eines qualitativ hochwertigen Düngers. Bezüglich der Lagerstabilität der Düngergranalien ist die Wasseraufnahme ein wichtiger Schlüsselfaktor. Während des Düngerherstellungsprozesses wird zur Produktverbesserung das Additiv Al2(SO4)3·14 H2O zugegeben, wobei verschiedene Aluminiumverbindungen entstehen. Es wird der Wasseraufnahmemechanismus des untersuchten Mischdüngers, bestehend aus Harnstoff und Ammoniumsulfat, mit Hilfe des Aluminiumhydroxids Al(OH)3 und dessen Polymorphe Bayerit, Gibbsit und Nordstrandit, sowie mit Aluminiumoxidhydroxid AlO(OH) (Böhmit) erklärt. Darüberhinaus wird ein Weg zur Optimierung der Lagerstabilität des Düngers über eine verlangsamte Wasseraufnahmegeschwindigkeit aufgezeigt.
MINLP Optimization of the Hybrid Separation Process Distillation/Melt Crystallization
Authors: Franke Meik 
Published: February 2011

AbstractDas Hybridverfahren aus Destillation und Schmelzkristallisation bietet bei engsiedenden Gemischen eine kostengünstige Alternative zur herkömmlichen Destillation. In dieser Arbeit wird die systematische Auslegung und kostenoptimale Gestaltung dieses Kombinationsverfahrens behandelt. Besonderer Schwerpunkt liegt dabei auf der optimalen Wahl der betrieblichen und strukturellen Freiheitsgrade.
Discovery and Development of Thiazolo[3,2‐a]pyrimidinone Derivatives as General Inhibitors of Bcl‐2 Family Proteins
Authors: Zhou Bingcheng , Li Xun , Li Yan , Xu Yaochun , Zhang Zhengxi , Zhou Mi , Zhang Xinglong , Liu Zhen , Zhou Jiahai , Cao Chunyang , Yu Biao , Wang Renxiao 
Published: February 2011

AbstractA class of compounds with a common thiazolo[3,2‐a]pyrimidinone motif has been developed as general inhibitors of Bcl‐2 family proteins. The lead compound was originally identified in a random screening of a small compound library using a fluorescence polarization‐based competitive binding assay. Its binding to the Bcl‐xL protein was further confirmed by 15N‐HSQC NMR experiments. Structural modifications on the lead compound were guided by the outcomes of molecular modeling studies. Among the 42 compounds obtained, a number of them exhibited much improved binding affinities to Bcl‐2 family proteins as compared to the lead compound. The most potent compound, BCL‐LZH‐40, inhibited the binding of BH3 peptides to Bcl‐xL, Bcl‐2, and Mcl‐1 with inhibition constants (Ki) of 17, 534, and 200 nM, respectively.