bluuebunny/crossref_metadata_2025_split huggingface dataset:
Improved MRI methods to quantify retinal and choroidal blood flow applied to a model of glaucoma
Authors: Jiang Zhao , Chernoff Diane , Galenchik-Chan Andre , Tomorri David , Honkanen Robert A. , Duong Timothy Q. , Muir Eric R. 
Published: May 2024

PurposeBlood flow (BF) of the retinal and choroidal vasculatures can be quantitatively imaged using MRI. This study sought to improve methods of data acquisition and analysis for MRI of layer-specific retinal and choroidal BF and then applied this approach to detect reduced ocular BF in a well-established mouse model of glaucoma from both eyes.MethodsQuantitative BF magnetic resonance imaging (MRI) was performed on glaucomatous DBA/2J and normal C57BL/6J mice. Arterial spin labeling MRI was applied to image retinal and choroidal BF using custom-made dual eye coils that could image both eyes during the same scan. Statistics using data from a single eye or two eyes were compared. BF values were calculated using two approaches. The BF rate per quantity of tissue was calculated as commonly done, and the peak BF values of the retinal and choroidal vasculatures were taken. Additionally, the BF rate per retinal surface area was calculated using a new analysis approach to attempt to reduce partial volume and variability by integrating BF over the retinal and choroidal depths.ResultsOcular BF of both eyes could be imaged using the dual coil setup without effecting scan time. Intraocular pressure was significantly elevated in DBA/2J mice compared to C57BL/6J mice (P&lt;0.01). Both retinal and choroidal BF were significantly decreased in DBA/2J mice in comparison to the age-matched normal C57BL/6J mice across all measurements (P &lt; 0.01). From simulations, the values from the integrated BF analysis method had less partial volume effect, and from in vivo scans, this analysis approach also improved power.ConclusionThe dual eye coil setup allows bilateral eye data acquisition, increasing the amount of data acquired without increasing acquisition times in vivo. The reduced ocular BF found using the improved acquisition and analysis approaches replicated the results of previous studies on DBA/2J mice. The ocular hypertensive stress-induced BF reduction found within these mice may represent changes associated with glaucomatous progression.
Case Report: A rare instance of acute appendicitis induced by Balantidium Coli parasitic infection
Authors: Alzate-Ricaurte Sergio , Garcia Moreno Isabel Cristina , Serna Lorza Juan David , Hincapie-Ayala Daniela , Diaz Maria Camila , Alzate Gallego Edgar Darío , Sanchez Sanchez Juan Pablo 
Published: May 2024

IntroductionAcute appendicitis secondary to parasitic infections is uncommon, being detected in less than 1% of cases. Balantidium coli is a parasite found in pigs and primates with zoonotic potential. To date, only three cases of acute appendicitis induced by this parasite have been documented globally.CaseA 7-year-old female patient, who consumed pork daily, presented to the emergency department with a one-day history of abdominal pain in the lower quadrants, described as colic-like, alongside abdominal distension. Initial abdominal radiography led to a diagnosis of intestinal obstruction. Conservative management without therapeutic response necessitated referral to a higher complexity center. Upon admission, an abdominal computed tomography scan diagnosed acute appendicitis and secondary ileus. During surgical intervention, an appendiceal phlegmon formed by loops of the small intestine was mechanically released, revealing a perforated appendix with extensive fecal peritoneal contamination. Pathological analysis identified an inflammatory infiltrate and the presence of Balantidium coli trophozoites. Medical treatment included Piperacillin-Tazobactam and Metronidazole. The patient was discharged after 10 days of medical treatment.DiscussionAcute appendicitis caused by Balantidium coli is a rare occurrence. It is crucial to identify parasites in pathological samples due to their impact on postoperative management. The close contact between humans and pigs, especially in developing countries, suggests that the prevalence of parasitic infection and colonization by Balantidium coli may be higher than currently recognized. Regarding the identification of this patient's specific exposure, the regular consumption of pork suggests the hypothesis that improper processing is linked to the acquisition of the parasitic infection.
A systematic review of the mechanism of action and potential medicinal value of codonopsis pilosula in diseases
Authors: Guo Huina , Lou YiChen , Hou Xiaofang , Han Qi , Guo Yujia , Li Zhongxun , Guan Xiaoya , Liu Hongliang , Zhang Chunming 
Published: May 2024

As a traditional Chinese medicinal herb with a long history, Codonopsis pilosula (CP) has attracted much attention from the medical community in recent years. This review summarizes the research progress of CP in the medical field in the past 5 years. By searching and analyzing the literature, and combining with Cytoscape software, we comprehensively examined the role and mechanism of action of CP in individual application, combination drug application, and the role and mechanism of action of codonopsis pilosula’s active ingredients in a variety of diseases. It also analyzes the medicinal use of CP and its application value in medicine. This review found that CP mainly manifests important roles in several diseases, such as cardiovascular system, nervous system, digestive system, immune system, etc., and regulates the development of many diseases mainly through the mechanisms of inflammation regulation, oxidative stress, immunomodulation and apoptosis. Its rich pharmacological activities and diverse medicinal effects endow CP with broad prospects and application values. This review provides valuable reference and guidance for the further development of CP in traditional Chinese medicine.
Effect of a helium and oxygen mixture on physiological parameters of rats with cerebral arterial air embolism
Authors: Palikov V. A. , Pavlov N. B. , Amirov R. R. , Ismailova A. M. , Borozdina N. A. , Palikova Yu. A. , Dyachenko I. A. , Khokhlova O. N. , Ponomareva T. I. , Rykov V. A. , Logunov A. T. , Murashev A. N. , Baranov V. M. 
Published: May 2024

Introduction: Cerebral arterial air embolism (CAE) is a serious and potentially dangerous condition that can interrupt the blood supply to the brain and cause stroke. One of the promising gas mixtures for emergency treatment of air embolism is an oxygen-helium mixture.Methods: We modeled CAE in awake rats by injecting air into the common carotid artery. Immediately after CAE, animals were either untreated or underwent hyperbaria, oxygen inhalation, heated air inhalation, or helium-oxygen mixture inhalation. Body temperature, locomotor activity, respiratory and cardiovascular parameters were monitored in the animals before CAE modeling, and 3 and 24 h after CAE modeling.Results: After 3 hours of CAE modeling in awake rats, depression of the nervous, cardiovascular and respiratory systems, as well as decreased body temperature were observed. 24 h after CAE modeling multifocal cerebral ischemia was observed. Normobaric helium-oxygen mixture inhalation, on par with hyperbaric treatment, restored body temperature, locomotor activity, respiratory volume, respiratory rate, and blood pressure 3 hours after CAE, and prevented the formation of ischemic brain damage lesions 24 h after CAE.Discussion: Thus, inhalation of a heated oxygen-helium gas mixture (O2 30% and He 70%) immediately after CAE improves the physiological condition of the animals and prevents the foci of ischemic brain damage formation.
Slow art plus: developing and piloting a single session art gallery-based intervention for mental health promotion via a mixed method waitlist randomized control trial
Authors: Ho Andy Hau Yan , Ma Stephanie Hilary Xinyi , Ng Jing Ting , Choo Ping Ying , Tan-Ho Geraldine , Pooh Karen Chuan Ling , Teng Alicia 
Published: May 2024

IntroductionThe current study builds on the expertise of National Gallery Singapore and Nanyang Technological University Singapore (NTU) in developing and piloting an enhanced version of the Slow Art program, namely “Slow Art Plus” for mental health promotion.MethodsA single-site, open-label, waitlist Randomized Control Trial (RCT) design comprising of a treatment group and waitlist control group was adopted (ClinicalTrials.gov ID: NCT05803226). Participants (N = 196) completed three online questionnaires at three timepoints: baseline [T1], immediately post-intervention/s baseline [T2], post-intervention follow-up/immediately post-intervention [T3]. Qualitative focus groups were conducted to evaluate program acceptability.ResultsA mixed model ANOVA was performed to understand intervention effectiveness between the immediate intervention group and waitlist control group. The analyses revealed a significant interaction effect where intervention group participants reported an improvement in spiritual well-being (p = 0.001), describing their thoughts and experiences (p = 0.02), and nonreacting to inner experiences (p = 0.01) immediately after Slow Art Plus as compared to the control group. Additionally, one-way repeated measure ANOVAs were conducted for the intervention group to evaluate maintenance effects of the intervention. The analyses indicated significant improvements in perceived stress (p &lt; 0.001), mindfulness (p &lt; 0.001) as well as multiple mindfulness subscales, active engagement with the world (p = 0.003), and self-compassion (p = 0.02) 1 day after the completion of Slow Art Plus. Results from framework analysis of focus group data revealed a total of two themes (1: Experiences of Slow Art Plus, 2: Insights to Effective Implementation) and six subthemes (1a: Peaceful relaxation, 1b: Self-Compassion, 1c: Widened Perspective, 2a: Valuable Components, 2b: Execution Requisites, 2c: Suggested Enhancements), providing valuable insights to the overall experience and implementation of the intervention.DiscussionSlow Art Plus represents a unique approach, offering a standardized, multimodal, single-session program that integrates mindfulness and self-compassion practices, as well as reflective and creative expressions with Southeast Asian art. It demonstrates potential in meeting the mental health needs of a wide range of individuals and could be readily incorporated into social prescribing initiatives for diverse populations.
Feasibility of hemoperfusion using extracorporeal therapy in the horse
Authors: Hobbs Kallie J. , Le Sueur Andre N. V. , Burke Megan J. , Cooper Bethanie L. , Sheats M. Katie , Ueda Yu 
Published: May 2024

ObjectiveDevelop, implement, and monitor for adverse effects of, a novel hemoperfusion therapy in adult horses.MethodsA prospective, observational feasibility study using three healthy adult horses from the North Carolina State University teaching herd. Health status was determined by physical exam, complete blood count, coagulation panel, and serum biochemistry. Each horse was instrumented with a 14 Fr × 25 cm double-lumen temporary hemodialysis catheter and underwent a 240 min polymer-based hemoperfusion session. Horses were administered unfractionated heparin to maintain anti-coagulation during the session. Given the novelty of this therapy in horses, each horse was treated as a learning opportunity that informed an iterative process of protocol development and modification.Measurements and main resultsOur long-term goal is to investigate potential clinical applications of hemoperfusion in horses, including cytokine reduction in horses with severe SIRS/sepsis. Horses were monitored for changes in clinical exam, biochemistry and hematology parameters. Additionally, cytokines were quantified to determine whether extracorporeal hemadsorption therapy alone caused an inflammatory response. Our results show that hemoperfusion therapy was associated with decreased platelet counts and serum albumin concentration. There was no significant change in plasma cytokine concentrations with hemoperfusion therapy. In one horse, the cytokine concentrations decreased, as previously reported with hemoperfusion therapy in humans.HypothesisWe hypothesized that hemoperfusion therapy could be performed in healthy adult horses without significant adverse effects.ConclusionPolymer-based hemoperfusion is a feasible extracorporeal therapy (ECT) modality for adult horses. Additional studies are needed to further establish clinical protocols, as well as establish efficacy of polymer-based hemoperfusion for treatment of various conditions in horses, including intoxications, immune-mediated conditions, and sepsis.
Psychotropic Medication Usage in Pediatric CKD: Reporting from the CKD in Children Cohort
Authors: Ward Ryan C. , Kogon Amy J. , Matheson Matthew B. , Dawson Anne , Hooper Stephen R. , Molitor Stephen , Wong Cynthia , Furth Susan L. , Warady Bradley A. , Harshman Lyndsay A. 
Published: May 2024

Key Points

Psychotropic medication use is prevalent in the pediatric CKD population.Central nervous system stimulant usage was more common in male patients, and antidepressant usage was more frequently reported at follow-up visits during teenage years.

Background
Mental health disorders within the pediatric CKD population are prevalent. The frequency is unknown with which psychotropic medications that commonly treat these conditions are used in this population.

Methods
Data from the CKD in Children (CKiD) cohort study were used to describe the use of psychotropic medications and patient-related characteristics of use. Medications were classified into three groups: antidepressants, central nervous system (CNS) stimulants, and antipsychotic/mood stabilizing medications. Participant age, sex, CKD severity, and duration of medication use were ascertained. Medication use was evaluated in parallel with CKD disease type, presence of urological comorbidity, and hypertension. Chi-square tests compared subgroup medication use.

Results
Among 1074 CKiD participants (median baseline age 9.8 years), 6% (n=60) used psychotropic medications at study entry with 11% reporting incident use of any medication category (n=120). CNS stimulants were most common at baseline. Antidepressants were more frequent among incident users at 7%. Use of two or more medications was rare (3%). Median eGFR at medication initiation was 45 ml/min per 1.73 m2. CNS stimulants were reported at a higher rate in male compared with female participants (P < 0.05).

Conclusions
Eleven percent of CKiD patients report incident use of any psychotropic medication, with 7% reporting incident use of antidepressants. Future work is warranted to better ascertain the frequency, safety, and efficacy of psychotropic medication usage in relationship to formal mental health disorder diagnoses in the pediatric CKD population.
PENGARUH PENDAMPINGAN GIZI TERHADAP PENINGKATAN PENGETAHUAN DAN UKURAN LINGKAR LENGAN ATAS PADA IBU HAMIL DENGAN KEKURANGAN ENERGI KRONIS (Di Wilayah Kerja Puskesmas Nelayan)
Authors: Afshokhun Nabila Mahcica , Mulyani Endah , Esty S Rizka , Mudlikah Siti 
Published: May 2024

Kekurangan energi kronis (KEK) pada ibu hamil ditandai dengan ukuran LiLA < 23.5cm merupakan kondisi ibu yang menderita kekurangan asupan energi. Pengukuran LILA sebagai alat yang cepat digunakan untuk memantau status gizi dan sangat berkolerasi dengan BMI. Ibu hamil dengan status gizi kurang selain berdampak pada kondisi janin yang dilahirkan juga berdampak pada proses persalinan, salah satu penanganan KEK pada ibu hamil dapat diatasi dengan memberikan edukasi gizi dengan pendampingan yang intensif oleh tenaga kesehatan. Tujuan dari penelitian ini adalah untuk menganalisis pengaruh pendampingan gizi online terhadap peningkatan pengetahuan dan ukuran lingkar lengan atas pada ibu hamil KEK. Menggunakan uji paired t-test dengan desain penelitian eksperimental dengan pendekatan one group pretest-posttest research design. Pengambilan sampel dilakukan secara total sampling dengan jumlah sampel 20 responden. Penelitian ini menggunakan instrument penelitian berupa kuesioner dan pengukuran lingkar lengan atas menggunakan pita Lila. Hail penelitian ini adalah ada pengaruh pendampingan gizi terhadap peningkatan pengetahuan dan ukuran lingkar lengan atas ibu hamil KEK. Diperoleh pada pengetahuan sebelum dan sesudah pendampingan p value (0.000<0.05), dan ukuran LILA sebelum dan sesudah pendampingan p value (0.034<0.05). Dari hasil penelitian yang didapat ada pengaruh pendampingan gizi terhadap peningkatan pengetahuan dan ukuran lingkar lengan atas pada ibu hamil KEK
Reactions of Citrullus amarus and Cucumis metuliferus to Meloidogyne chitwoodi, Meloidogyne enterolobii and Meloidogyne luci
Authors: FULLANA Aida Magdalena , MALEITA Carla , SANTOS Duarte , ABRANTES Isabel , SORRIBAS Francisco Javier , GINÉ Ariadna 
Published: May 2024

Meloidogyne chitwoodi, M. enterolobii, and M. luci are present in some EU countries, with restricted distributions, and plant resistance can be used to manage these nematodes. Two pot experiments were conducted under controlled conditions for 56 d to assess the host suitability of two potential rootstocks, Cucumis metuliferus BGV11135 and Citrullus amarus BGV5167, to one isolate of each nematode. The susceptible cucumber (Cucumis sativus) ‘Dasher II’, watermelon (Citrullus lanatus) ‘Sugar Baby’ and tomato (Solanum lycopersicum) ‘Coração-de-Boi’ were included for comparisons. A histopathological study using confocal-laser microscopy was also conducted 15 d after nematode inoculations. In the pot test, the rootstocks showed lower numbers of galls, egg masses, and eggs per plant than their susceptible ones. Reproduction indices of the rootstocks varied from immune to moderately resistant, depending on the isolate-rootstock combination. In the histopathological study, M. enterolobii and M. luci induced similar numbers of giant cells (GC) per feeding site in all germplasms. However, GC volumes and numbers of nuclei in rootstocks were lower than in the susceptible germplasms. GCs induced by M. chitwoodi were only detected in susceptible cucumber. These results emphasize the potential of C. metuliferus and C. amarus as effective, eco-friendly strategies for managing root-knot nematodes, and show the complex these host-pathogen interactions.
Ginger Rhizome Extract (Zingiber officinale) as an Alternative Bioinsecticide Against The Mortality of German Cockroach (Blattella germanica)
Authors: Susanto Inneke Kusumawati , Susilowati Rina Priastini , Hidajat Joshua Jean Michael 
Published: May 2024

Kecoak merupakan salah satu serangga yang berada dimana-mana. Kecoa dapat tinggal di berbagai tempat, mulai dari selokan, tempat sampah, sampai di kamar mandi. Kecoak adalah salah satu agen penularan untuk berbagai penyakit seperti diare, disentri dan kolera pada anak-anak. Di Indonesia, terdapat berbagai jenis kecoak yang sering ditemukan, salah satunya adalah Kecoak Jerman atau Blattella germanica L., dan masalah kecoak di Indonesia ditangani dengan penggunaan insektisida kimiawi, hal ini terjadi karena banyaknya dan mudah dicarinya insektisida kimiawi di berbagai tempat, seperti di supermarket, warung, sampai toko kecil-kecilan. Insektisida kimiawi berbahan dasar piretroid adalah salah satu insektisida kimiawi yang paling umum dipakai oleh masyarakat. Insektisida kimiawi tersebut memiliki berbagai macam efek buruk yang diakibatkan karena ia meninggalkan residu yang dapat terhirup oleh manusia dan juga terkonsumsi oleh manusia melalui produk pangan. Beberapa efek insektisida kimiawi adalah penyakit hati, ginjal, dan juga masalah pada sistem saraf pusat. Oleh karena itu dibutuhkan solusi alternatif dalam penanganan masalah kecoak di Indonesia, yaitu Bioinsektisida. Bioinsektisida adalah insektisida yang dibuat menggunakan bahan-bahan alami tanpa adanya penambahan zat-zat kimiawi. Jahe adalah salah satu rempah yang dapat ditemukan dimana-mana, di dalam jahe terdapat senyawa yang bernama flavonoid, dan senyawa ini lah yang dapat menjadi biopestisida. Biopestisida dibuat dengan mengambil ekstrak jahe lalu memasukkan ekstrak ke dalam botol penyemprotan sesuai dengan dosisnya menggunakan pipet pasteur.
Kata Kunci: Kecoak, piretorid, bioinsektisida, jahe
Tinjauan Variasi Produk Vitamin Blackmores Di PT. Enseval Putera Megatrading Bogor
Authors: Zahdi Fahmi Ramadhan , Suardy Weman 
Published: May 2024

Vitamin products have become a necessity for society, because people gain many benefits by consuming vitamin products according to their individual needs. PT. Enseval Putera Megatrading Tbk is a company that operates in the distribution and logistics sector through the provision of health products. The aim of the research is to find out; 1. To find out what variations of Blackmores products are available at PT. Enseval Putera Megatrading; 2. To find out what the obstacles are to blackmores product variations at PT. Enseval Putera Megatrading; 3. to find out how to deal with obstacles to Balckmores product variations at PT. Enseval Putera Megatrading. The Research result; 1. PT. Enseval Putera Megatrading applies product variation measures, namely width, length, depth, consistency; 2. several obstacles; when there is a resizing of product variations from the initial product to smaller contents, customers prefer the more economical ones so that the initial product becomes slow moving; 3. In an effort to overcome the problem of slow moving initial products, the company provides bonus prizes so that customers are more interested in purchasing initial products that contain more content.

Keywords: Product Variations, Blackmores Vitamins
Descripción del Clima Emprendedor de las Pymes en la Ciudad de Pilar. Caso: Confeccionistas Textiles, Periodo 2023
Authors: Martínez Jiménez Alberto 
Published: May 2024

La investigación tiene por objetivo general: Describir el estado del clima emprendedor en las microempresas confeccionistas en la ciudad de Pilar, año 2023, basada en las variables. Estado del Clima Emprendedor: Innovación en las microempresas confeccionistas, Crecimiento y sostenibilidad de las microempresas, Nivel de competitividad en el mercado y Satisfacción y retención de empleados en las microempresas. La metodología utilizada fue la mixta. Investigación que permitió llegar a la conclusión: Que existen un porcentaje elevado de los confeccionistas quienes sí tienen acceso a créditos o préstamos para financiar sus operaciones, así también un porcentaje elevado de microempresarios establecen relaciones con entidades financieras, una ya sólidas, como bancos o cooperativas de crédito para que las microempresas puedan obtener recursos financieros cuando sea necesario y otras no. Por lo general la valoración de la percepción de las actitudes y valores empresariales en el sector de confección en la ciudad de Pilar es elevado siendo calificados en el nivel 3, 4 y 5 con “Emprendedor y "Muy emprendedor”. En tal sentido existen algunos valores y actitudes comunes que son apreciados en el ámbito de las Pymes emprendedoras como la honestidad y la transparencia en que operan y que les ayuda a ganar la confianza de los clientes y empleados, la innovación, los que los ayuda a adoptar nuevas ideas y actualizaciones en máquinas y tecnologías para la adaptabilidad y el éxito de las Pymes, también se rescata el valor del trabajo en equipo, la colaboración y la capacidad de trabajar eficazmente buscando la eficiencia colectiva y sobre todo el compromiso con la calidad.