bluuebunny/crossref_metadata_2025_split huggingface dataset:
[68Ga]Ga-NODAGA-TriGalactan, a low molecular weight tracer for the non-invasive imaging of the functional liver reserve
Authors: Zierke Maximilian A. , Rangger Christine , Samadikhah Kimia , Panzer Marlene , Dichtl Stefanie , Hörmann Nikolas , Wilflingseder Doris , Schmid Andreas M. , Haubner Roland 
Published: May 2024

Abstract
Background
Determination of the functional liver mass is important in a variety of clinical settings including liver surgery and transplantation. [99mTc]Tc-diethylenetriamine-pentaacetic acid galactosyl human serum albumin (99mTc-GSA) is a radiotracer targeting the asialoglycoprotein receptor (ASGR) and is routinely used in Japan for this purpose. Here we describe the development and evaluation of [68Ga]Ga-NODAGA-TriGalactan a low molecular weight PET-tracer targeting this structure.

Results
For synthesis TRIS as branching unit and NODAGA as chelator for labelling with [68Ga]Ga are included. Three galactose moieties are conjugated via a click chemistry approach resulting in the desired labelling precursor.68Ga-labelling could be accomplished in high radiochemical yield and purity. [68Ga]Ga-NODAGA-TriGalactan is very hydrophilic and revealed high plasma stability and low plasma protein binding. Fluorescence imaging showed binding on ASGR-positive organoids and the IC50-value was in the nanomolar range. Most importantly, both biodistribution as well as animal imaging studies using normal mice demonstrated high liver uptake with rapid elimination from all other organs leading to even higher liver-to-background ratios as found for 99mTc-GSA.

Conclusion
[68Ga]Ga-NODAGA-TriGalactan shows high in vitro stability and selectively binds to the ASGR allowing imaging of the functional liver mass with high contrast. Thus, our first generation compound resulted already in an alternative to 99mTc-GSA for imaging the functional liver reserve and might allow the broader use of this imaging technique.
Cardiac repolarization abnormalities and neurally mediated syncope: overlooked aspects in the diagnosis of pheochromocytoma
Authors: Cotias Elisama Pimentel Zamian , Neto Jorge Elias , Gomes Luiz Fernando Mazzini , Merçon Erick Sessa , Kuniyoshi Ricardo , Silva Márcio Augusto 
Published: May 2024

Abstract
Background
Pheochromocytoma is a rare catecholamine-producing tumour originating from adrenal chromaffin cells. Classic clinical presentation includes headache, diaphoresis and palpitation. Syncope is uncommon and may result from hypotension or arrhythmia. We report a case of neurally mediated syncope in pheochromocytoma associated with cardiac repolarization abnormalities, a unique presentation of the disease.

Case presentation
This case report presents a 28 year-old woman, describing recurrent syncope usually preceded by prodromes such as headache, visual blurring, heart palpitations and psychomotor agitation. Firstly she was diagnosed with anxiety and depression, but there was no improvement of symptoms with psychiatric treatment. Previous Holter revealed long QT interval. Echocardiogram showed normal dimensions, preserved left ventricular function and no valvopathies. The patient was referred for a Head-up tilt test (HUTT) in order to investigate reflex syncope. The electrocardiogram (ECG) exhibited normal sinus rhythm and diffuse cardiac repolarisation abnormalities. HUTT was positive for vasodepressor type neurally mediated syncope and ECG showed U waves after a syncope episode. This electrocardiographic finding motivated further clinical investigation. The patient also described abdominal pain, increased abdominal volume, weight loss and blood pressure instability. Based on clinical history and ventricular repolarisation abnormalities uncovered by HUTT, pheochromocytoma was suspected. Urinary test was positive for catecholamines and the abdominal imaging revelead expansive lesion. She underwent surgery to remove the pheochromocytoma, confirmed by immunohistochemistry.

Conclusions
After surgery she had no recurrency of symptoms, remaining asymptomatic after six years of follow-up, suggesting a cause-effect relationship between neurally mediated syncope and pheochromocytoma.
V4RIN: visual analysis of regional industry network with domain knowledge
Authors: Xiong Wenli , Yu Chenjie , Shi Chen , Zheng Yaxuan , Wang Xiping , Hu Yanpeng , Yin Hong , Li Chenhui , Wang Changbo 
Published: May 2024

AbstractThe regional industry network (RIN) is a type of financial network derived from industry networks that possess the capability to describe the connections between specific industries within a particular region. For most investors and financial analysts lacking extensive experience, the decision-support information provided by industry networks may be too vague. Conversely, RINs express more detailed and specific industry connections both within and outside the region. As RIN analysis is domain-specific and current financial network analysis tools are designed for generalized analytical tasks and cannot be directly applied to RINs, new visual analysis approaches are needed to enhance information exploration efficiency. In this study, we collaborated with domain experts and proposed V4RIN, an interactive visualization analysis system that integrates predefined domain knowledge and data processing methods to support users in uploading custom data. Through multiple views in the system panel, users can comprehensively explore the structure, geographical distribution, and spatiotemporal variations of the RIN. Two case studies were conducted and a set of expert interviews with five domain experts to validate the usability and reliability of our system.
Sustainable supply chain management and organizational performance: the mediating role of competitive advantage in Ethiopian manufacturing industry
Authors: Shebeshe Ephrem Negash , Sharma Dhiraj 
Published: May 2024

Abstract
Purpose
This research aims to study the impact of sustainable supply chain management on both competitive advantage and organizational performance in the Ethiopian manufacturing industry.

Design/methodology/approach
The objectives are achieved through collecting and analyzing data from 221 Ethiopian manufacturing industries. This research employs a quantitative approach, specifically descriptive and causal research methods. The data are collected by questionnaires administered directly to a sample of 221 respondents who are managers and supervisors in the manufacturing industry. In addition, data analysis was performed using structural equation modeling in the Smart-PLS Software version (SmartPLS 4.0).

Findings
The research reveals that SSCM substantially and positively impacts competitive advantage and organizational performance. Furthermore, statistical findings prove the connection between competitive advantage and organizational performance. Moreover, competitive advantage indirectly influences the relationship between SSCM and OP. The results suggest that successfully implementing SSCM can improve competitive advantage and OP.

Originality/value
Considering the triple-bottom-line approach and the mediating effects of competitive advantage, this study is the first to analyze the relationship between SSCM and manufacturing performance in Ethiopia. This study adds to the existing literature by providing empirical evidence on the impact of sustainable supply chain management (SSCM) on competitive advantage and organizational performance in the manufacturing industry of emerging markets.

Research limitations/implications
The research is based on a cross-sectional study, which may prevent the generalization of findings derived from the current study. The analyzed variable in this study quantified OP, which is widely recognized as a very dynamic concept.
Expert evidence: dangers and the enhancement of reasoning
Authors: Charleton Peter , Rakhmanin Ivan 
Published: May 2024

SUMMARYThis article considers the role of experts and their interaction with the legal system to better understand the benefits and potential dangers of expert evidence to fact-finders in trials. Medical experts are indispensable to the administration of justice as litigation ranges beyond what judges or juries comfortably deal with as facts of everyday life. This would render courts, absent expert evidence, vastly under-equipped in making decisions of fact. However, the dangers of surrendering authority to experts or of misunderstanding their role must be considered to ensure that expert evidence is used to benefit the administration of justice.
Modified gravity theories from the Barrow hypothesis
Authors: Anand Ankit , Campos Delgado Ruben 
Published: May 2024

Abstract
Barrow proposed that quantum gravity effects might introduce fractal corrections to the area of the event horizon of black holes. The area law gets modified as

, with

. It was so far unclear whether this assumption could lead to meaningful quantum gravity theories beyond general relativity. In this paper, we argue that this is indeed the case. In particular, assuming Δ to be a radial function, we show that the Barrow hypothesis, together with Jacobson's approach can generate non-trivial modified gravity theories.
Dynamics of the nonlinear optical second- and third-harmonic generation in
quantum well due to hydrostatic pressure and temperature
Authors: Yan Xiaolong , Li Xuechao , Cai Yawen 
Published: May 2024

Abstract
We studied the effects of hydrostatic pressure and temperature on the second- and third-harmonic generation (SHG and THG) in semi-parabolic GaAs/Al0.3Ga0.7As quantum wells. By solving the Schrödinger equation numerically, we can determine the system's sub-band energy levels and wave functions, and then calculate its optical gain. The numerical simulation results show that both temperature and hydrostatic pressure can effectively improve the nonlinear optical performance of the system. Notably, we explore the mechanisms underlying these interactions. These findings suggest a viable approach to adjust the nonlinear optical performance of GaAs/Al0.3Ga0.7As quantum system through the subtle interaction between hydrostatic pressure, temperature and structural parameters.
Normative Data for Insulin-Like Growth Factor 1 in Healthy Children and Adolescents From India
Authors: Ravi Teja Kasagani Venkata , Malhotra Bhanu , Vogel Mandy , Marwaha Raman Kumar , Aggarwal Arun , Pal Rimesh , Das Liza , Sachdeva Naresh , Devi Nagita , Bansal Dipika , Rastogi Ashu , Sharma Sadhna , Gajinder Dewan , Bhadada Sanjay Kumar , Ghosh Jayaditya , Monaghan Phillip J , Korbonits Márta , Dutta Pinaki 
Published: May 2024

Abstract

Background
Serum insulin-like growth factor 1 (IGF-1) is an important biochemical tool to diagnose and monitor growth hormone (GH)-related disorders. However, ethnicity-specific Indian data, following consensus criteria for the establishment of normative data, are not available. Our objective was to generate chronological age (CA)-, bone age (BA)- and Tanner stage–specific normative data for IGF-1 in healthy Indian children and adolescents.

Methods
A cross-sectional epidemiological study was conducted in schools and the community, which enrolled apparently healthy children and adolescents with robust exclusion criteria. The outcome measure was serum IGF-1 assessed using an electro-chemiluminescence immunoassay (ECLIA). The 2.5th, 5th, 10th, 25th, 50th (median), 75th, 90th, 95th, and 97.5th centiles for IGF-1 were estimated using generalized additive models.

Results
We recruited 2226 apparently healthy participants and following exclusion, 1948 (1006 boys, 942 girls) were included in the final analysis. Girls had median IGF-1 peak at CA of 13 years (321.7 ng/mL), BA of 14 years (350.2 ng/mL) and Tanner stage IV (345 ng/mL), while boys had median IGF-1 peak at CA of 15 years (318.9 ng/mL) BA of 15 years (340.6 ng/mL) and Tanner stage III (304.8 ng/mL). Girls had earlier rise, earlier peak, and higher IGF-1 values. The reference interval (2.5th to 97.5th percentile) was broader during peripubertal ages, indicating a higher physiological variability.

Conclusion
This study provides ethnicity-specific normative data on serum IGF-1 and will improve the diagnostic utility of IGF-1 in the evaluation and management of growth disorders in Indian children and adolescents.
Anticoagulants - The Past, The Present, The Future - A Systematic Review
Authors: Warzycka Klaudia , Maliszewska Karolina , Woźniak Kinga , Gardian-Baj Monika , Jung Magdalena , Hedesz Patryk , Jung Maximilian , Doryń Aleksandra , Jędral Krystian , Włodarczyk Aleksandra , Szczerbiak Alicja 
Published: May 2024

Introduction: Anticoagulants have been discovered and developed over past 100 years. At the beginning unfractionated heparin found its applications, just later to fade into the background of newer and more effective drugs. Patients have been treated with more progressive medications – Low-Molecule-Weight Heparin (LMWH), Vitamin K Antagonists (VKA) and Novel Oral Anticoagulants (NOAC). As for today, deemed a turning point in anticoagulant therapy are inhibitors of factor XI. It is a ground-breaking innovation as it ensures high prevention of thrombotic episodes and guarantees intact physiological hemostasis.Current State of Knowledge: The coagulation cascade and molecules part taking in that have been discovered and described extensively and in detail. Unfractionated heparin is the oldest out of all and despite its simple action mechanism and adverse effects, is still a requested drug. Its lighter form, low-molecule-weight-heparin (LMWH) is an enhancement to the previous treatment due to its higher bioavailability and fewer side effects. Vitamin K antagonists (VKAs) are widely spread in medical environment thanks to their expanded mechanism of action, oral administration and reversibility of their overdose, as well as their well-developed anti-side effect therapy. Novel Oral Anticoagulants (NOACs) have been introduced to the market about 10 years ago. In spite of NOACs short period of clinical use, they were a huge change to the previous treating methods. Currently, the newest innovation in anticoagulant therapy are inhibitors of factor XI and its clinical trials outcome is promising for the future.Summary: The present article discusses history of anticoagulant drugs, their mechanism of action and usage but also focuses on the recent perspectives and developments as new anticoagulant drugs are being put to the test in therapeutic trials. The review underlines the importance of improvements in old therapeutic methods and exploring the new, more suitable ones.
Online Integrated Production and Distribution Scheduling: Review and Extensions
Authors: Chen Zhi-Long 
Published: May 2024

As a growing number of manufacturers adopt the make-to-order business mode and a growing number of retailers sell online, we are seeing numerous decision problems that can be modeled as what are known in the literature as integrated production and distribution scheduling (IPDS) problems. In such problems, order processing and delivery must be scheduled jointly in order to achieve an optimal balance between total operational costs and overall customer service. Offline IPDS problems, in which the information about every order is known in advance with certainty, are extensively studied. However, research on online IPDS problems, in which orders arrive randomly with their information unknown until they arrive, is relatively recent but is growing rapidly. In this paper, we first describe several real-world applications to illustrate the importance of studying online IPDS problems from a practical point of view. We then review the existing literature on online IPDS problems with a focus on existing online algorithms for these problems and their theoretical performance. We also derive some new results to fill several gaps left in the literature and discuss possible topics for future research. History: Accepted by Andrea Lodi, Area Editor for Design & Analysis of Algorithms–Discrete. Supplemental Material: The online appendix is available at https://doi.org/10.1287/ijoc.2022.0305 .
Genetic predisposition to vaccine-induced immune thrombotic thrombocytopenia: is there a family link?
Authors: Pombal Rita , Silva Luciana , Ferreira David 
Published: May 2024

Background: Vaccine-induced immune thrombotic thrombocytopenia (VITT) is a rare life-threatening thrombotic reaction to COVID-19 vaccines. Case description: Two young male first cousins, with a family history of idiopathic thrombocytopenic purpura, developed VITT after the Ad26.COV2.S vaccine. Both had a favourable clinical and analytical outcome. We investigated the genetic factors that could be associated with a genetic predisposition to VITT. Conclusions: There are no published cases where the VITT patients were relatives. The genetic study did not reveal any likely pathogenic variants, although the prevalent polymorphism c.497A>G (p.(His166Arg)) in the FCGR2A gene was found in a homozygous state. More studies are required to better understand VITT’s pathophysiology and any underlying genetic predispositions.
Prehospital management of sepsis with IV antibiotics: a UK literature review
Authors: Jadzinski Patryk , Fouch Sarah , Markham Chris , Stores Rebecca 
Published: May 2024

Background:Sepsis mortality rates increase if prompt treatment is not administered. The Sepsis Six care bundle advocates the early administration of broad-spectrum intravenous antibiotics to reduce mortality and morbidity but this is not routinely practised nationally in UK prehospital settings, although UK ambulance services regularly attend septic patients.Aims:A literature review was conducted to investigate knowledge around paramedics' ability to recognise and treat prehospital sepsis with intravenous antibiotics in the UK and the impact of this on patient outcomes.Methods:A search was conducted and the three eligible studies included underwent a structured critical appraisal and thematic analysis.Findings:Three themes emerged: diagnostic accuracy; administration of prehospital antibiotics; and impact on patient outcomes.Conclusion:There is a significant gap in evidence in this field in the UK, and it was difficult to make generalised recommendations from the studies. Paramedics have the potential to be highly accurate in the recognition of sepsis and administer intravenous antibiotics when following a protocol. No major studies measure patient outcomes following prehospital intravenous antibiotics administration by paramedics in the UK and large empirical studies should be conducted to assess the effectiveness of this.
Theoretical and experimental analysis of the complex dynamics of spectral RMS width of an erbium-doped figure eight fiber laser
Authors: González-Galicia M. A. 
Published: May 2024

There are a large number of different ultrashort light pulses; a particular case is called noise-like pulses (NLPs), which are ultrashort light pulses that have the characteristic that their electric field has a very complex internal structure. Due to this characteristic, the envelope can take various shapes (Gaussian, triangular, square, complex shape, etc.). Also its amplitude and temporal width vary with respect to the polarization within the cavity. In this work we carry out a theoretical and experimental study of the RMS widths of NLPs measured within the mode-locked regions generated with our laser cavity: an erbium-doped figure eight fiber laser (EDFEFL). The experimental measurements of the RMS widths of the NLPs were compared with the theoretical model of light intensity transmission based on Jones matrices and with the theoretical model of the NOLM. We find that the theoretical model partially fits with the experimental results. We analyze NLPs with a wavelength carrier of 960 nm, repetition rate of 60 MHz, and temporal profile with duration on the order of nanoseconds.
S+E+O-band luminescence and enhancement in Nd3+/Tm3+/Ce3+ doped tellurite glass
Authors: Zhou Dexing , Wang Shuhong , Zhao Dongyi , Zhu Liqiao , Zhou Yaxun 
Published: May 2024

A new, to our knowledge, doped combination of Nd3+, Tm3+, and Ce3+ ions was developed in tellurite glass with a fundamental composition of TeO2-ZnO-WO3-Bi2O3, and the structural, thermal, and especially near-infrared (NIR) luminescent properties in O-, E-, and S-bands were explored. The XRD pattern confirmed the amorphous nature of synthesized tellurite glass, the Raman spectrum disclosed different structural units that make up the glass network, the DSC curve confirmed good host thermal stability, while XPS measurement revealed that cerium mainly exists in the trivalent form in a glass network. Upon being pumped with an 808 nm laser, a 1.34 µm band fluorescence from Nd3+:4F3/2level→4I13/2 level transition and a 1.46 µm band fluorescence from Tm3+:3H4level→3F4 level transition were observed, which in turn formed a wide luminescence band from 1260 to 1560 nm in the tellurite glass containing both Nd3+ and Tm3+ ions owing to their spectral overlapping. The measured full width at half maximum (FWHM) for the aforementioned wideband luminescence was about 203 nm with Nd2O3 and Tm2O3 concentrations of 0.015 mol. % and 0.5 mol. %, respectively, and exhibited a further ∼60% increase in peak intensity after the incorporation of 0.4 mol. % amount of CeO2, which arises from the phenomena of cross relaxation and energy transfer among the three trivalent rare earth ions. The experimental evidence presented in this work shows that tellurite glass containing Nd3+, Tm3+, and Ce3+ has potential as an active material for S-, E-, and O-band wideband luminescence.