bluuebunny/crossref_metadata_2025_split huggingface dataset:
Reduced Mortality Among Department of Veterans Affairs Patients With Schizophrenia or Bipolar Disorder Lost to Follow-up and Engaged in Active Outreach to Return for Care
Authors: Davis Chester L. , Kilbourne Amy M. , Blow Frederic C. , Pierce John R. , Winkel Bernard M. , Huycke Edward , Langberg Robert , Lyle David , Phillips Yancy , Visnic Stephanie 
Published: January 2012

Objectives. We determined whether contacting Department of Veterans Affairs (VA) patients with schizophrenia or bipolar disorders (serious mental illness [SMI]) who had dropped out of care for prolonged periods resulted in reengagement with VA services and decreased mortality. Methods. We developed a list of patients with SMI who were last treated in fiscal years 2005 to 2006, and were lost to follow-up care for at least 1 year. VA medical centers used our list to contact patients and schedule appointments. Additional VA administrative data on patient utilization and mortality through May 2009 were analyzed. Results. About 72% (2375 of 3306) of the patients who VA staff attempted to contact returned for VA care. The mortality rate of returning patients was significantly lower than that for patients not returning (0.5% vs 3.9%; adjusted odds ratio = 5.8; P < .001), after demographic and clinical factors were controlled. Conclusions. The mortality rate for returning patients with SMI was almost 6 times less than for those who did not return for medical care. Proactive outreach might result in patients returning to care and should be implemented to reengage this vulnerable group.
Effects of butorphanol on the minimum anesthetic concentration for sevoflurane in guineafowl (Numida meleagris)
Authors: Escobar André , Valadão Carlos A. A. , Brosnan Robert J. , Denicol Anna C. , Flôres Fabíola N. , Thiesen Roberto , Coelho Cássia M. M. 
Published: January 2012

Abstract
Objective—To determine the minimum anesthetic concentration (MAC) for sevoflurane and measure the dose and temporal effects of butorphanol on the MAC for sevoflurane in guineafowl.
Animals—10 healthy adult guineafowl (Numida meleagris).
Procedures—Each bird was anesthetized with sevoflurane, and a standard bracketing method was used to measure the MAC in response to a noxious electrical stimulus. Subsequently, conditions were adjusted so that each bird was anesthetized with sevoflurane at a fraction of its respective MAC (eg, 0.7 times the MAC for that bird). Butorphanol tartrate (2 mg/kg, IV) was administered, and a noxious stimulus was applied every 15 minutes until the bird moved in response. The reduction in MAC was estimated with logistic regression by use of a standard quantal method. After an interval of ≥ 1 week, the MAC reduction experiment was repeated with an increased butorphanol dosage (4 mg/kg).
Results—Individual mean ± SE MAC for sevoflurane was 2.9 ± 0.1%. At 15 minutes after administration of 2 mg of butorphanol/kg, estimated reduction in the MAC for sevoflurane was 9 ± 3%. At 15 and 30 minutes after administration of 4 mg of butorphanol/kg, estimated reduction in the MAC for sevoflurane was 21 ± 4% and 11 ± 8%, respectively.
Conclusions and Clinical Relevance—In guineafowl, the MAC for sevoflurane was similar to values reported for other species. Increasing the butorphanol dosage decreased the MAC for sevoflurane, but the effect was small and of short duration for dosages up to 4 mg/kg.
Evaluation of tyrosinase expression in canine and equine melanocytic tumors
Authors: Phillips Jeffrey C. , Lembcke Luis M. , Noltenius Christina E. , Newman Shelley J. , Blackford James T. , Grosenbaugh Deborah A. , Leard A. Timothy 
Published: January 2012

Abstract
Objective—To determine the tissue-restricted expression pattern of tyrosinase mRNA in canine and equine melanocytic tumors and relative tyrosinase and major histocompatibility complex (MHC) I mRNA expression in variants of melanocytic tumors.
Sample—39 canine and 8 equine tumor samples and 10 canine and 6 equine normal tissue samples.
Procedures—RNA was isolated from formalin-fixed, paraffin-embedded tissues. Real-time PCR assays were designed to amplify canine and equine tyrosinase, S18 ribosomal RNA, and major histocompatibility complex I transcripts. Relative expression was determined by use of S18 as a reference and comparison with pigmented and nonpigmented normal tissues.
Results—High tyrosinase expression was found in all melanocytic tumors, compared with normal tissues, and expression had no correlation with presence or absence of tumor pigmentation. No significant difference in tyrosinase expression was found among histologic variants of melanocytic tumors. No correlation was found between MHC I and tyrosinase expression or tissue histologic classification.
Conclusions and Clinical Relevance—In the present study, the methods used were highly sensitive and specific for detection of tyrosinase expression in equine and canine tumors, and overexpression of this transcript in melanomas was detected. This suggested that a DNA vaccine developed for use in dogs with melanoma that targets tyrosinase may be considered for use in other affected species, such as horses.
Bioavailability and pharmacokinetics of oral and injectable formulations of methadone after intravenous, oral, and intragastric administration in horses
Authors: Linardi Renata L. , Stokes Ashley M. , Keowen Michael L. , Barker Steven A. , Hosgood Giselle L. , Short Charles R. 
Published: January 2012

Abstract
Objective—To characterize the bioavailability and pharmacokinetics of oral and injectable formulations of methadone after IV, oral, and intragastric administration in horses.
Animals—6 healthy adult horses.
Procedures—Horses received single doses (each 0.15 mg/kg) of an oral formulation of methadone hydrochloride orally or intragastrically or an injectable formulation of the drug orally, intragastrically, or IV (5 experimental treatments/horse; 2-week washout period between each experimental treatment). A blood sample was collected from each horse before and at predetermined time points over a 360-minute period after each administration of the drug to determine serum drug concentration by use of gas chromatography–mass spectrometry analysis and to estimate pharmacokinetic parameters by use of a noncompartmental model. Horses were monitored for adverse effects.
Results—In treated horses, serum methadone concentrations were equivalent to or higher than the effective concentration range reported for humans, without induction of adverse effects. Oral pharmacokinetics in horses included a short half-life (approx 1 hour), high total body clearance corrected for bioavailability (5 to 8 mL/min/kg), and small apparent volume of distribution corrected for bioavailability (0.6 to 0.9 L/kg). The bioavailability of methadone administered orally was approximately 3 times that associated with intragastric administration.
Conclusions and Clinical Relevance—Absorption of methadone in the small intestine in horses appeared to be limited owing to the low bioavailability after intragastric administration. Better understanding of drug disposition, including absorption, could lead to a more appropriate choice of administration route that would enhance analgesia and minimize adverse effects in horses.
Effect of scaffold dilution on migration of mesenchymal stem cells from fibrin hydrogels
Authors: Hale Benjamin W. , Goodrich Laurie R. , Frisbie David D. , McIlwraith C. Wayne , Kisiday John D. 
Published: January 2012

Abstract
Objective—To evaluate the effect of fibrin concentrations on mesenchymal stem cell (MSC) migration out of autologous and commercial fibrin hydrogels.
Sample—Blood and bone marrow from six 2- to 4-year-old horses.
Procedures—Autologous fibrinogen was precipitated from plasma and solubilized into a concentrated solution. Mesenchymal stem cells were resuspended in fibrinogen solutions containing 100%, 75%, 50%, and 25% of the fibrinogen precipitate solution. Fibrin hydrogels were created by mixing the fibrinogen solutions with MSCs and thrombin on tissue culture plates. After incubation for 24 hours in cell culture medium, the MSCs that had migrated onto the tissue culture surface and beyond the boundary of the hydrogels were counted. This procedure was repeated with a commercial fibrin sealant.
Results—Hydrogel-to-surface MSC migration was detected for all fibrin hydrogels. Migration from the 25% autologous hydrogels was 7.3-, 5.2-, and 4.6-fold higher than migration from 100%, 75%, and 50% autologous hydrogels, respectively. The number of migrating cells from 100%, 75%, and 50% autologous hydrogels did not differ significantly. With commercial fibrin sealant, the highest magnitude of migration was from the 25% hydrogels, and it was 26-fold higher than migration from 100% hydrogels. The 75% and 50% hydrogels resulted in migration that was 9.5- and 4.2-fold higher than migration from the 100% hydrogels, respectively.
Conclusions and Clinical Relevance—MSC migration from fibrin hydrogels increased with dilution of the fibrinogen component for both autologous and commercial sources. These data supported the feasibility of using diluted fibrin hydrogels for rapid delivery of MSCs to the surface of damaged tissues.
Hydrothermal synthesis of momordica-like CuO nanostructures using egg white and their characterisation
Authors: Zou Yun-Ling , Li Yan , Li Jian-Gang , Xie Wan-Jie 
Published: January 2012

AbstractIn this paper, we report on the preparation of momordica-like CuO nanostructures by the hydrothermal method using freshly extracted egg white protein (ovalbumin) in an aqueous medium. These momordica-like CuO nanostructures were characterised by X-ray diffraction (XRD) and field-emission scanning electron microscopy (FE-SEM). XRD patterns showed that these nanostructures had a polycrystalline nature with a monoclinic structure. FE-SEM images indicated that the momordica-like CuO nanostructures obtained at 180°C for 15 h were composed of CuO nanorods with a length of less than 100 nm and a width ranging from 30 nm to 50 nm. Finally, a possible growth mechanism for the momordica-like CuO nanostructures is proposed and discussed.
Experimental Analysis of the Reynolds Flocking Model*
Authors: Eversham J.D. , Ruiz V.F. 
Published: January 2012

AbstractThe classic Reynolds flocking model is formally analysed, with results presented and discussed. Flocking behaviour was investigated through the development of two measurements of flocking, flock area and polarisation, with a view to applying the findings to robotic applications. Experiments varying the flocking simulation parameters individually and simultaneously provide new insight into the control of flock behaviour.
Effect of Salinity on the Oxygen Consumption of Tilapia Fingerlings
Authors: Awal Md Abdul , Kuri Kartik Chandra , Sarker Subrata 
Published: January 2012

Fingerlings of tilapia were used to compare the oxygen consumption rates at 0, 10, 20 and 30 ppt salinity. Oxygen consumption of tilapia at 0, 10, 20 and 30 ppt salinity was found 2.14, 0.71, 1.43 and 1.42 ml/liter/h respectively. Oxygen consumption rate thereafter decreased with increasing salinity, although the lowest consumption occurred at 10 ppt. Lower consumption at high salinities might be a result of reduced activity, which in itself was salinitymodulated. The fish in this study were in or near a resting state, and that differences in oxygen consumption rates probably were related to the energetic cost of ionic and osmotic regulation. Again, mechanism in the fill tissue might involve significant energy-consuming processes in different water salinities compared to fresh water.Keywords: Fingerlings; water salinities; Ionic regulation; osmic regulationsDOI: http://dx.doi.org/10.3329/diujst.v7i1.9581 Daffodil International University Journal of Science and Technology Vol.7(1) 2012 12-14
Isolates Application of Multi-Functional Finishes on Denim Garments
Authors: Vijayalakshmi D , Ramachandran T 
Published: January 2012

The main aim of this research is to apply the functional finishes to denim garments to enhance the value of the garment. The fabric selected for the research is 100% cotton with the construction of 2/1 Right Hand Twill. The selected fabric was made into garments (A-line frock) and subjected to de-sizing and enzyme washing and then the garments were treated with two different synthetic scents sweet citrus and rose oils to induce fragrance. The garments were also tested for the efficacy of anti-microbial, antifungal, UV protection, stain repellency and mosquito repellency finishes. The results have proven very good sense of functional finishes on to the garments in conjunction with a sweet fragrance. Two different methods – dip dry and micro encapsulation methods were chosen for the study and the fastness property of the finishes were compared. The treated garments were evaluated using AATCC standards. Keywords: fragrance finish; anti-microbial finish; anti-fungal finish; A-line frock; enzyme washing. DOI: http://dx.doi.org/10.3329/diujst.v7i1.9649 Daffodil International University Journal of Science and Technology Vol.7(1) 2012 59-66
Regional Connectivity: Opportunities for Bangladesh to be a Transport Hub
Authors: Rahmatullah M 
Published: January 2012

In a globalized economy, transport cost being a significant determinant of competitiveness, it makes integrated and efficient transport network an essential element of the enabling environment. The integrated transport infrastructure, which South Asia inherited from the British, got fractured initially by the partition of India, and subsequently by its political aftermath and now needs to be rebuilt within the context of greater political harmony in South Asia. Such integration is especially crucial to countries such as Nepal and Bhutan and the regions such as North East India, as this could serve to end their landlocked or semi-isolated status and provide shorter transport and transit access to sea ports. To establish a case for regional transport connectivity in South Asia, an analysis was made of the impact of noncooperation in transport. An assessment was also made of the unique geographical location of Bangladesh having two landlocked countries, such as Nepal and Bhutan and one semilandlocked territory, North East India at the hinterland, and the opportunities this situation provides to Bangladesh. Based on SAARC Regional Multimodal Transport Study (SRMTS) findings, an attempt was made to identify a few strategic routes which could be pursued to provide transport connectivities among the countries of North East Sub-region of South Asia. An indication is made in this paper on the possible benefits that Bangladesh and the other neighboring countries could derive from the regional transport connectivities when established, to show that it would be a win-win situation for all. Finally, the study concludes that the cost of non-cooperation being very high, it would be beneficial for all the concerned countries to go for regional transport connectivity at the earliest. It was, however pointed out that issues related to regional connectivity and transit cannot be resolved in isolation. It needs to be considered together with other unresolved issues, in the areas of water sharing, environment, marine boundary, etc. What is needed for a long lasting solution is the political will and commitment of the leaders of South Asia, who should sit together with an open mind to resolve various issues once for all.DOI: http://dx.doi.org/10.3329/jbip.v2i0.9553 Journal of Bangladesh Institute of Planners Vol. 2, December 2009, pp. 13-29
Exhibition Session of the exp.atâ??11 International Conference
Authors: Restivo Teresa , Cardoso Alberto 
Published: January 2012

Man has been the humanityâ??s engineer for ages - human knowledge has been continuously built on conceptualization based on constant learning by doing activities. The observation and understanding of concepts and principles in action are the bases of the experimental activity leading to the correlation between reality and theory.
Experimental activities are really important, contributing to prepare the future engineers for solving practical problems and for consolidating theoretical understanding and volatile knowledge based on abstract concepts.
Therefore, experimental activity has been an essential part of education and training for engineers and engineering scientists.
exp.atâ??11 (the 1st Experiment@ International Conference) has been the first event of a new International Conference Experiment@ series devoted to online experimentation, enlarging the world capabilities in this particular area and contributing to collaborative work in emergent technologies, bringing together engineers, researchers and professionals from different areas. In its Exhibition Session, participants demonstrated their systems within developments of educational, medical and industrial applications.
Regulatory Dendritic Cells Pulsed with Carbonic Anhydrase I Protect Mice from Colitis Induced by CD4+CD25− T Cells
Authors: Yamanishi Hirofumi , Murakami Hidehiro , Ikeda Yoshiou , Abe Masanori , Kumagi Teru , Hiasa Yoichi , Matsuura Bunzo , Onji Morikazu 
Published: January 2012

Abstract
Inflammatory bowel disease (IBD), which is characterized by a dysregulated intestinal immune response, is postulated to be controlled by intestinal self-antigens and bacterial Ags. Fecal extracts called cecal bacterial Ag (CBA) have been implicated in the pathogenesis of IBD. In this study, we identified a major protein of CBA related to the pathogenesis of IBD and established a therapeutic approach using Ag-pulsed regulatory dendritic cells (Reg-DCs). Using two-dimensional gel electrophoresis and MALDI-TOF mass spectrometry, carbonic anhydrase I (CA I) was identified as a major protein of CBA. Next, we induced colitis by transfer of CD4+CD25− T cells obtained from BALB/c mice into SCID mice. Mice were treated with CBA- or CA I-pulsed Reg-DCs (Reg-DCsCBA or Reg-DCsCA1), which expressed CD200 receptor 3 and produced high levels of IL-10. Treatment with Reg-DCsCBA and Reg-DCsCA1 ameliorated colitis. This effect was shown to be Ag-specific based on no clinical response of irrelevant Ag (keyhole limpet hemocyanin)-pulsed Reg-DCs. Foxp3 mRNA expression was higher but RORγt mRNA expression was lower in the mesenteric lymph nodes (MLNs) of the Reg-DCsCA1–treated mice compared with those in the MLNs of control mice. In the MLNs, Reg-DCsCA1–treated mice had higher mRNA expression of IL-10 and TGF-β1 and lower IL-17 mRNA expression and protein production compared with those of control mice. In addition, Reg-DCsCBA–treated mice had higher Foxp3+CD4+CD25+ and IL-10–producing regulatory T cell frequencies in MLNs. In conclusion, Reg-DCsCA1 protected progression of colitis induced by CD4+CD25− T cell transfer in an Ag-specific manner by inducing the differentiation of regulatory T cells.
HLA Anchor Optimization of the Melan-A–HLA-A2 Epitope within a Long Peptide Is Required for Efficient Cross-Priming of Human Tumor-Reactive T Cells
Authors: Chauvin Joë-Marc , Larrieu Pierre , Sarrabayrouse Guillaume , Prévost-Blondel Armelle , Lengagne Renée , Desfrançois Juliette , Labarrière Nathalie , Jotereau Francine 
Published: January 2012

AbstractThe uptake and long-term cross-presentation of tumor Ag long peptides (LP) by dendritic cells (DC) make them attractive cancer vaccine candidates. However, it remains to be established whether LP can prime long-lived tumor-reactive CTL and whether other cell types are able to cross-present them. Using HLA-A2 healthy donor and melanoma patient-derived PBMC, we studied the in vitro cross-priming potential of Melan-A 16–40 LP bearing the HLA-A2–restricted epitope 26–35 or its analog 26–35A27L and compared it to the priming capacity of the short analog. We then addressed LP priming capacity in vivo using HLA-A2 mice. We also studied LP cross-presentation by monocyte-derived DC, plasmacytoid DC, monocytes, and B cells. We showed that the modified LP gave rise to high and sustained cross-presentation by monocyte-derived DC. This led to cross priming in vitro and in vivo and to expansion of long-lived tumor-reactive cytotoxic T cells. In contrast, the LP containing the natural 26–35 epitope primed specific T cells poorly, despite its long-lived cross-presentation, and T cells primed against the short analog were short-lived. We further showed that LP cross-presentation is restricted to monocytes and conventional DC. These results document for the first time, to our knowledge, the strong immunogenicity of a human tumor Ag LP. Of note, they underscore that this property is critically dependent on sufficient HLA binding affinity and/or TCR ligand potency of the cross-presented epitope. We conclude that LP fulfilling this requirement should be used as tumor vaccines, together with DC maturating agents, especially the Melan-A 16–40A27L LP, for the treatment of HLA-A2+ melanoma patients.
Phacoemulsification and goniosynechialysis for the management of refractory acute angle closure
Authors: Fakhraie Ghasem , Vahedian Zakieh , Moghimi Sasan , Eslami Yadollah , Zarei Reza , Oskouee Jafar Faraji 
Published: January 2012

Purpose To evaluate the effectiveness of phacoemulsification with goniosynechialysis in the management of refractory acute angle closure (AAC). Methods In this prospective, noncomparative interventional case series, patients with AAC who were unresponsive to medical and laser therapy were included. Success was defined as complete if intraocular pressure (IOP) had a drop of at least 30% and was between 6 and 21 mmHg without medication, and qualified if IOP was within that range with medication. Results A total of 24 patients with a mean age of 56 years (range 39-77) were treated. Mean follow-up time was 15.7±4.2 months (range 6-24). Mean preoperative and last visit IOPs were 34.27±7.23 mmHg and 17.5±3.21 mmHg, respectively (p<0.001). Mean number of glaucoma medication dropped from 3.67±0.48 to 0.63±1.05 (p<0.001). There was a positive correlation between the attack–surgery interval and last visit IOP (p<0.001, r=0.697). There was a negative correlation between the preoperative anterior chamber depth and last visit IOP drop (p=0.03, r=–0.56). Also, a positive correlation was found between the preoperative IOP and last visit IOP drop (p<0.001, r=0.896). At final visit, complete and qualified success was achieved in 17/24 (71%) and 5/24 (21%) cases, respectively. The most common intraoperative and postoperative complications were hyphema and anterior chamber fibrinous reaction, respectively. Conclusions Phacoemulsification with goniosynechialysis seems to be a safe and effective method for the management of patients with refractory AAC. This procedure can be considered for these patients before proceeding with filtering surgery.
Common and Uncommon Complications of Totally Implantable Central Venous Ports: A Pictorial Essay
Authors: Perdikakis Evangelos , Kehagias Elias , Tsetis Dimitrios 
Published: January 2012

Purpose The purpose of this study is to present the characteristic radiologic features of common and uncommon complications in totally implantable central venous ports. Material and Methods The authors reviewed 138 implantations of central venous ports in oncologic patients during an 18-month period and present the characteristic imaging features of the complications detected. Results All chest ports were placed via the internal jugular vein using both fluoroscopic and ultrasound guidance. The technical success rate was 99.3% (137/138). All catheter or port-related complications were retrospectively assessed. Sixteen complications were detected during the follow-up period, and catheter removal was required in 10 patients. Conclusions Image-guided central venous port catheter implantation is a very safe procedure with a low rate of complications. The typical imaging features of common and uncommon complications are very helpful in establishing the correct diagnosis and thus tailoring the appropriate therapy.