bluuebunny/crossref_metadata_2025_split huggingface dataset:
ChemInform Abstract: Four‐ and Eight‐Carbon Homologation of Benzaldehyde by (1Z,3Z)‐Butyltelluro‐1,3‐butadiene (I). Synthesis of Navenone B (VI). Alarm Pheromone of the Mollusk Navanax inermis.
Authors: Dabdoub Miguel J. , Dabdoub Vania B. , Baroni Adriano C. M. , Barbosa Sandro L. 
Published: August 2012

AbstractThe natural product navenone B is synthesized in seven steps starting from commercially available methoxy‐1‐buten‐3‐yne.
ChemInform Abstract: Biotemplated Synthesis of Perovskite Nanomaterials for Solar Energy Conversion.
Authors: Nuraje Nurxat , Dang Xiangnan , Qi Jifa , Allen Mark A. , Lei Yu , Belcher Angela M. 
Published: August 2012

AbstractStrontium titanate and bismuth ferrite perovskite nanomaterials are prepared from ethylene glycol solutions of SrCl2 and TiCl4, and Bi(NO3)3 and Fe(NO3)3, resp., using genetically engineered M13 virus as a mineralizer (80 °C, 4 h).
Characteristics of Responders to Cardiac Resynchronization Therapy: The Impact of Echocardiographic Left Ventricular Volume
Authors: Park Mi Young , Altman Robert K. , Orencole Mary , Kumar Prabhat , Parks Kimberly A. , Heist Kevin E. , Singh Jagmeet P. , Picard Michael H. 
Published: August 2012

AbstractBackground:One‐third of patients who receive cardiac resynchronization therapy (CRT) are classified as nonresponders. Characteristics of responders to CRT have been studied in multiple clinical trials.Hypothesis:Independent predictors of CRT response may be identified by studying a series of patients in routine clinical practice.Method:One hundred twenty‐five patients were examined retrospectively from a multidisciplinary CRT clinic program. Echocardiographic CRT response was defined as a decrease in left ventricular (LV) end‐systolic volume of ≥15% and/or absolute increase of 5% in LV ejection fraction at the 6‐month visit.Results:There were 81 responders and 44 nonresponders. By univariate analyses, female sex, nonischemic cardiomyopathy etiology, baseline QRS duration, the presence of left bundle branch block (LBBB), and left ventricular end‐diastolic volume (LVEDV) index predicted CRT response. However, multivariate analysis demonstrated that only QRS duration, LBBB, and LVEDV index were independent predictors (QRS width, odds ratio [OR]: 1.027, 95% confidence interval [CI]: 1.004–1.050, P = 0.023; LBBB, OR: 3.568, 95% CI: 1.284–9.910, P = 0.015; LVEDV index, OR: 0.970, 95% CI: 0.953–0.987, P = 0.001). Although female sex and nonischemic etiology were associated with an improved CRT response on univariate analyses, after adjusting for LV volumes they were not independent predictors.Conclusions:QRS width, LBBB, and LVEDV index are independent predictors for echocardiographic CRT response. Previously reported differences in CRT response for sex and cardiomyopathy etiology are associated with differences in baseline LV volumes in our clinical practice.Dr. Heist has received research grants (modest) from Biotronik, Boston Scientific, and St. Jude Medical; honoraria (modest) from Biotronik, Boston Scientific, Medtronic, Sorin, and St. Jude Medical; and consultant/advisory board positions (modest) from Boston Scientific, Sorin and St. Jude Medical. Dr. Singh has received research grants (significant) from Biotronik, Boston Scientific, Medtronic, and St. Jude Medical; and consultant/advisory board positions (modest) from Biosense Webster, Biotronik, Boston Scientific, CardioInsight, Medtronic, Sorin, St. Jude Medical, and Thoratec Inc.The statistical analysis was conducted with support from Harvard Catalyst. The Harvard Clinical and Translational Science Center (National Center for Research Resources and the National Center for Advancing Translational Sciences, National Institutes of Health Award UL1 RR 025758, and financial contributions from Harvard University and its affiliated academic healthcare centers).The authors have no other funding, financial relationships, or conflicts of interest to disclose.
Groundwater Defluoridation with Raw Bauxite, Gypsum, Magnesite, and Their Composites
Authors: Thole Bernard , Mtalo Felix , Masamba Wellington 
Published: August 2012

AbstractBreakthrough characteristics, kinetics, and dose‐effect in defluoridation with bauxite, gypsum, magnesite, and their composites were determined. The aim was to identify optimum filter and configuration viable for groundwater defluoridation. Bed depth service time (BDST) design model and empty bed residence time (EBRT) optimization model were employed to characterize breakthrough. Higher doses obtained lower loading capacities but higher sorption percentages and breakthrough times. Breakthrough times obtained were 50 400, 32 400, 25 200, and 19 800 s for 150, 120, 75, and 45 g, respectively. The equation ħ = 1.0 × 10−4 δ2 −0.022 δ + 1.5053 defined the operating line with ħ, adsorbent exhaustion rate, in g L−1 and δ, EBRT, in seconds. A critical bed depth (Zo) of 6.56 cm was obtained. Second order kinetic rate constants were 0.73, 1.17, and 1.81 g mg−1 s−1 for magnesite, gypsum, and bauxite, respectively. The composite, gypsum and bauxite decreased water pH but magnesite increased pH in water defluoridation. Experimental data did not fit the two‐parameter logistics model; model values were significantly different from experimental values. Optimum defluoridation characteristics were obtained in fixed bed. Despite high residual sulphates and apparent color, fixed‐bed defluoridation with raw composites of these materials, treated in this manner, is viable.
Arylamine‐Modified Thiazoles as Donor–Acceptor Dyes: Quantum Chemical Evaluation of the Charge‐Transfer Process and Testing as Ligands in Ruthenium(II) Complexes
Authors: Menzel Roberto , Kupfer Stephan , Mede Ralf , Weiß Dieter , Görls Helmar , González Leticia , Beckert Rainer 
Published: August 2012

AbstractA series of new 4‐hydroxy‐1,3‐thiazole‐based chromophores bearing different arylamine components (triarylamines, carbazole, and phenothiazine) as electron donors and azaheterocycle components (pyridine, pyrazine and pyrimidine) as electron‐acceptor moieties have been synthesized. Elaborate quantum chemical calculations were carried out with two selected compounds to identify the natures of the HOMO/LUMO transition and of the intramolecular charge‐transfer state. The electrochemical properties were investigated: the dyes show reversible first oxidation and reduction peaks, with the former strongly dominated by the type of arylamine. The donor moieties were synthesized under Buchwald–Hartwig conditions. Several of the presented X‐ray structures provide deeper insight into the geometries of the ligands. The bidentate nature of the chromophores makes them suitable as ligands in transition metal complexes. The corresponding ruthenium(II) polypyridine complexes – Ru(dmbpy)2(L)(PF6)2 (dmbpy = 4,4′‐dimethyl‐2,2′‐bipyridine) – were successfully synthesized for seven of the ligands. The MLCT bands in these complexes are significantly broadened, resulting in improved light‐harvesting efficiencies.
Evidence of time‐dependent prognostic factors predicting early death but not long‐term outcome in primary CNS lymphoma: a study of 91 patients
Authors: Ghesquières Hervé , Drouet Youenn , Sunyach Marie Pierre , Sebban Catherine , Chassagne‐Clement Catherine , Jouanneau Emmanuel , Honnorat Jérome , Biron Pierre , Blay Jean Yves 
Published: August 2012

AbstractLong‐term primary CNS lymphoma (PCNSL) survivors could have multiple adverse prognostic factors at diagnosis such as age, performance status (PS), site of the tumour (deep vs superficial), lactate dehydrogenase (LDH) level and CSF protein level. Whether these five prognostic factors integrated in the International Extranodal Lymphoma Study Group (IELSG) score have a time‐dependent effect is questionable. Among 132 PCNSL patients treated at our institution between 1984 and 2006, 91 available patients for IELSG score were evaluated by time‐segmented analysis. Of the 91 patients, 21% had 0–1, 59% had 2–3 and 20% had 4–5 adverse IELSG prognostic scores. With a median follow‐up of 102 months, the median overall survival (OS) of the 91 patients with the five prognostic factors of IELSG score was 33 months (95% CI, 17 to 55) compared with 14 months (95% CI, 3 to 23) for the remaining 41 patients whose CSF protein level was lacking in the IELSG score. These 41 patients who did not have lumbar puncture presented a poorer PS at diagnosis and a lower treatment response rate. While confirming the prognostic value of the IELSG score, we observed a time‐dependent effect of age, PS and tumour site; all three lost their prognostic value after 6 months from diagnosis, while LDH remained a constant predictor of OS. No prognostic impact of CSF protein level was reported. Patients with older age, poor PS and deep brain involvement are at risk of death during the first months after diagnosis but could have a favourable long‐term outcome after the treatment period. New prognostic factors predicting long‐term outcome remain to be determined. Copyright © 2012 John Wiley & Sons, Ltd.
Exposure time to caffeine affects heartbeat and cell damage‐related gene expression of zebrafish Danio rerio embryos at early developmental stages
Authors: Abdelkader Tamer Said , Chang Seo‐Na , Kim Tae‐Hyun , Song Juha , Kim Dong Su , Park Jae‐Hak 
Published: August 2012

ABSTRACTCaffeine is white crystalline xanthine alkaloid that is naturally found in some plants and can be produced synthetically. It has various biological effects, especially during pregnancy and lactation. We studied the effect of caffeine on heartbeat, survival and the expression of cell damage related genes, including oxidative stress (HSP70), mitochondrial metabolism (Cyclin G1) and apoptosis (Bax and Bcl2), at early developmental stages of zebrafish embryos. We used 100 µm concentration based on the absence of locomotor effects. Neither significant mortality nor morphological changes were detected. We monitored hatching at 48 h post‐fertilization (hpf) to 96 hpf. At 60 and 72 hpf, hatching decreased significantly (P < 0.05); however, the overall hatching rate at 96 hpf was 94% in control and 93% in caffeine treatment with no significant difference (P > 0.05). Heartbeats per minute were 110, 110 and 112 in control at 48, 72 and 96 hpf, respectively. Caffeine significantly increased heartbeat – 122 and 136 at 72 and 96 hpf, respectively. Quantitative RT‐PCR showed significant up‐regulation after caffeine exposure in HSP70 at 72 hpf; in Cyclin G1 at 24, 48 and 72 hpf; and in Bax at 48 and 72 hpf. Significant down‐regulation was found in Bcl2 at 48 and 72 hpf. The Bax/Bcl2 ratio increased significantly at 48 and 72 hpf. We conclude that increasing exposure time to caffeine stimulates oxidative stress and may trigger apoptosis via a mitochondrial‐dependent pathway. Also caffeine increases heartbeat from early phases of development without affecting the morphology and survival but delays hatching. Use of caffeine during pregnancy and lactation may harm the fetus by affecting the expression of cell‐damage related genes. Copyright © 2012 John Wiley & Sons, Ltd.
Electrospun tubular scaffolds: On the effectiveness of blending poly(ε‐caprolactone) with poly(3‐hydroxybutyrate‐co‐3‐hydroxyvalerate)
Authors: Del Gaudio Costantino , Fioravanzo Lara , Folin Marcella , Marchi Fabiana , Ercolani Enrico , Bianco Alessandra 
Published: August 2012

AbstractTissue engineering can effectively contribute to the development of novel vascular prostheses aimed to overcome the well‐known drawbacks of small‐diameter grafts. To date, poly(ε‐caprolactone) (PCL), a bioresorbable synthetic poly(α‐hydroxyester), is considered one of the most promising materials for vascular tissue engineering. In this work, the potential advantage of intimate blending soft PCL and hard poly(3‐hydroxybutyrate‐co‐3‐hydroxyvalerate) (PHBV), a polymer of microbial origin, has been evaluated. Nonwoven mats and small‐diameter tubular scaffolds of PCL, PHBV, and PCL/PHBV were fabricated by means of electrospinning technique. Mechanical properties and suture retention strength were investigated according to the international standard for cardiovascular implants. Biological tests demonstrated that both PCL‐based scaffolds supported survival and growth of rat cerebral endothelial cells in a short time. The fiber alignment of the electrospun tubular scaffolds contributed to a more rapid and homogeneous cell colonization of the luminal surface. © 2012 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2012.
Controllable delivery of hydrophilic and hydrophobic drugs from electrospun poly(lactic‐co‐glycolic acid)/mesoporous silica nanoparticles composite mats
Authors: Song Botao , Wu Chengtie , Chang Jiang 
Published: August 2012

AbstractCo‐delivery of several drugs has been regarded as an alternative strategy for achieving enhanced therapeutic effect. In this study, a co‐delivery system based on the electrospun poly(lactic‐co‐glycolic acid) (PLGA)/mesoporous silica nanoparticles (MSNs) composite mat was designed for the co‐encapsulation and prolonged release of one hydrophilic and one hydrophobic drug simultaneously. MSNs were chosen to load the hydrophobic model drug fluorescein (FLU) and hydrophilic model drug rhodamine B (RHB), respectively (named as RHB‐loaded MSNs and FLU‐loaded MSNs). Two kinds of drug‐loaded MSNs were incorporated into the polymer matrix to form a fibrous structure by blending electrospinning. The effect of the weight ratios for the two kinds of drug‐loaded MSNs and the initial PLGA concentrations on the drug release kinetics were systematically investigated. The results showed that both model drugs RHB and FLU maintained sustained delivery with controllable release kinetics during the releasing period, and the release kinetics was closely dependent on the loading ratios of two drug‐loaded MSNs and the initial PLGA concentrations in the composite mats. The results suggest that the co‐drug delivery system may be used for wound dressing that requires the combined therapy of several kinds of drugs. © 2012 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2012.
Tensile mechanical properties and hydraulic permeabilities of electrospun cellulose acetate fiber meshes
Authors: Stylianopoulos Triantafyllos , Kokonou Maria , Michael Stefanos , Tryfonos Antonia , Rebholz Claus , Odysseos Andreani D. , Doumanidis Charalambos 
Published: August 2012

AbstractThe mechanical properties and hydraulic permeabilities of biomaterial scaffolds play a crucial role in their efficacy as tissue engineering platforms, separation processors, and drug delivery vehicles. In this study, electrospun cellulose acetate fiber meshes of random orientations were created using four different concentrations, 10.0, 12.5, 15.0, and 17.5 wt % in acetone or ethyl acetate. The tensile mechanical properties and the hydraulic permeabilities of these meshes were measured, and a multiscale model was employed to predict their mechanical behavior. Experimentally, the elastic modulus ranged from 3.5 to 12.4 MPa depending on the polymer concentration and the solvent. Model predictions agreed well with the experimental measurements when a fitted single‐fiber modulus of 123.3 MPa was used. The model also predicted that changes in fiber alignment may result in a 3.6‐fold increase in the elastic modulus for moderately aligned meshes and a 8.5‐fold increase for highly align meshes. Hydraulic permeabilities ranged from 1.4 x 10−12 to 8.9 x 10−12 m2 depending on polymer concentration but not the choice of solvent. In conclusion, polymer concentration, fiber alignment, and solvent have significant impact on the mechanical and fluid transport properties of electrospun cellulose acetate fiber meshes. © 2012 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2012.
Pharmacophore Mode lingand Virtual Screening to Design the Potential Influenza Virus Endonuclease Inhibitors
Authors: Liao Huang‐Sheng , Wu Josephine W. , Liu Hsuan‐Liang , Zhao Jian‐Hua , Tsao Cheng‐Wen , Liu Kung‐Tien , Chuang Chih‐Kuang , Lin Hsin‐Yi , Tsai Wei‐Bor , Ho Yih 
Published: August 2012

AbstractInfluenza virus endonuclease is an attractive target for antiviral therapy in the treatment of influenza infection. The purpos e of this study is to design a novel antiviral agent with improved biological activities against the influenza virus endonuclease. In this study, chemical feature‐based 3D pharmacophore models were developed from 41 known influenza virus endonuclease inhibitors. The best quantitative pharmacohore model (Hypo 1), which consists of two hydrogen‐bond acceptors and two hydrophobic features, yields the highest correlation coefficient (R = 0.886). Hypo 1 was further validated by the cross validation method and the test set compounds. The application of this model for predicting the activities of 11 known influenza virus endonuclease inhibitors in the test set shows great success. The correlation coefficient of 0.942 and a cross validation of 95;% confidence level prove that this model is reliable in identifying structurally diverse compounds for influenza virus endonuclease inhibition. The most active compound (compound 1) from the training set was docked into the active site of the influenza virus endonuclease as an additional verification that the pharmacophore model is accurate. The docked conformation showed important hydrogen bond interactions between the compound and two amino acids, Lys 134 and Lys 137. After validation, this model was used to screen the NCI chemical database to identify new influenza virus endonuclease inhibitors. Our study shows that the to pranking compound out of the 10 newly identified compounds using fit value ranking has an estimated activity of 0.049 μM. These newly identified lead compounds can be further experimentally validated using in vitro techniques.
Sensitive Electrochemical Determination of Catechol with a Graphene Modified Carbon Ionic Liquid Electrode
Authors: Ruan Chengxiang , Li Tongtong , Wang Xiuzheng , Qi Xiaowei , Lou Jin , Gao Weimin , Sun Wei 
Published: August 2012

AbstractIn this paper a graphene (GR) modified carbon ionic liquid electrode (CILE) was fabricated and used as the voltammetric sensor for the sensitive detection of catechol. Due to the specific physicochemical characteristics of GR such as high surface area, excellent conductivity and good electrochemical properties, the modified electrode exhibits rapid response and strong catalytic activity with high stability toward the electrochemical oxidation of catechol. A pair of well‐defined redox peaks appeared with the anodic and the cathodic peak potential located at 225 mV and 133 mV (vs.SCE) in pH 6.5 phosphate buffer solution, respectively. Electrochemical behaviors of catechol on the GR modified CILE were carefully investigated and the electrochemical parameters were calculated with the results of the electrode reaction standard rate constant (ks) as 1.24 s−1, the charge transfer coefficient (α) as 0.4 and the electron transfer number (n) as 2. Under the selected conditions the differential pulse voltammetric peak current increased linearly with the catechol concentrations in the range from 1.0 × 10‐7 to 7.0 × 10−4mol L‐1 with the detection limit as 3.0 × 10−8mol L‐1 (3σ). The proposed method was further applied to the synthetic waste water samples determination with satisfactory results
Transport Properties of Nano‐sized TiO2‐based Composite Polymer Electrolyte Prepared by a Green Method
Authors: Lin Yun‐Chih , Cheng Ju‐Hsiang , M. Venkateswarlu , Wang Fu‐Ming , Santhanam Raman , Hwang Bing Joe 
Published: August 2012

AbstractThe transport properties of the nano‐sized TiO2‐based composite polymer electrolyte (CPE) membrane prepared by a green process were investigated. The ion transport phenomena of the CPE was probed by 7Li solid state NMR spectroscopy and it was found that the lithium ions exist in different environments and were respectively ascribed to the interactions of lithium ions and ether groups, anions and also nano‐sized TiO2 particles. Further, the NMR line width become narrowing with temperature suggests that the decrease of ion‐pair interaction in themodified CPE. The NMR data is consistent with the conductivity data observed from impedance spectroscopy as a function of temperature. These results suggest that the CPE could be prepared satisfactorily by a greenmethod in which water was used as a solvent instead of organic solvents like THF. In addition, the developed green method is simple, cost effective and environmentally benign due to the absence of hazardous organic solvents.
Effects of Chemical Dispersant and Wet Mechanical Milling Methods on Conductive Carbon Dispersion and Rate Capabilities of LiFePO4 Batteries
Authors: Chang Chia‐Chin , Su Huang‐Kai , Her Li‐Jane , Lin Jarrn‐Horng 
Published: August 2012

AbstractThe dispersion state of conductive carbons in the cathodes of lithium ion batteries fabricated with a dispersant and with/without mechanical milling are considered with regard to the batteries' charge–discharge properties. Suspensions of Ketjen black (KB, EC 300J and EC 600JD) are dispersed in an organic solvent. Ball milling is then performed, modifying the particle sizes and structures. Results show improved dispersion but with collateral reduction of both maximum and average particle sizes. The more fragile EC 600JD, after ballmilling, is broken into more small segments than EC 300J, but with segment density high enough for loose coupling to form networks. Therefore, the electron conduction of EC600JD after ball milling is better than EC 300J. The high‐rate discharge capacity of EC600JD after ball milling is also better than that of EC 300J. However, rate capabilities decrease with increasing milling time.
Embryonic defects and growth alteration in mice with homozygous disruption of thePatz1gene
Authors: Valentino Teresa , Palmieri Dario , Vitiello Michela , Simeone Antonio , Palma Giuseppe , Arra Claudio , Chieffi Paolo , Chiariotti Lorenzo , Fusco Alfredo , Fedele Monica 
Published: August 2012

AbstractPATZ1is an emerging cancer‐related gene coding for a POZ/AT‐hook/kruppel Zinc finger transcription factor, which is lost or misexpressed in human neoplasias. Here, we investigated its role in development exploring wild‐type and Patz1‐knockout mice during embryogenesis. We report that thePatz1gene is ubiquitously expressed at early stages of development and becomes more restricted at later stages, with high levels of expression in actively proliferating neuroblasts belonging to the ventricular zones of the central nervous system (CNS). The analysis of embryos in whichPatz1was disrupted revealed the presence of severe defects in the CNS and in the cardiac outflow tract, which eventually lead to a pre‐mature in utero death during late gestation or soon after birth. Moreover, the Patz1‐null mice showed a general growth retardation, which was consistent with the slower growth rate and the increased susceptibility to senescence of Patz1−/−mouse embryonic fibroblasts (MEFs) compared to wild‐type controls. Therefore, these results indicate a critical role of PATZ1 in the control of cell growth and embryonic development. J. Cell. Physiol. 228: 646–653, 2013. © 2012 Wiley Periodicals, Inc.
AKT as locus of cancer multidrug resistance and fragility
Authors: Radisavljevic Ziv 
Published: August 2012

AbstractComplexity and robustness of cancer hypoxic microenvironment are supported by the robust signaling networks of autocrine and paracrine elements creating powerful interactome for multidrug resistance. These elements generate a positive feedback loops responsible for the extreme robustness and multidrug resistance in solid cancer, leukemia, myeloma, and lymphoma. Phosphorylated AKT is a cancer multidrug resistance locus. Targeting that locus by oxidant/antioxidant balance modulation, positive feedback loops are converted into negative feedback loops, leading to disappearance of multidrug resistance. This is a new principle for targeting cancer multidrug resistance by the locus chemotherapy inducing a phenomenon of loops conversion. J. Cell. Physiol. 228: 671–674, 2013. © 2012 Wiley Periodicals, Inc.