bluuebunny/crossref_metadata_2025_split huggingface dataset:
The relationship between low prolactin and type 2 diabetes
Authors: Ken-Dror Gie , Fluck David , Lean Michael E. J. , Casanueva Felipe F. , Han Thang Sieu 
Published: May 2024

AbstractProlactin (PRL) is secreted throughout life in men and women. At elevated levels, its physiological role in pregnancy and lactation, and pathological effects, are well known. However clinical implications of low circulating PRL are not well established. We conducted a meta-analysis to examine the relationship between low PRL levels and type 2 diabetes. Five papers included cross-sectional studies comprising 8,720 men (mean age range 51.4–60 years) and 3,429 women (49.5–61.6 years), and four papers included cohort studies comprising 2,948 men (52.1–60.0 years) and 3,203 women (49.2–60.1 years). Individuals with pregnancy, lactation and hyperprolactinemia, drugs known to alter circulating PRL levels, or pituitary diseases had been excluded. Although most studies used quartiles to categorize PRL groups for analysis, PRL cut-off values (all measured by chemiluminescence immunoassay) were variably defined between studies: the lowest PRL quartiles ranged from 3.6 ng/ml to 7.2 ng/ml in men and between 4.5 ng/ml to 8 ng/ml in women; and the highest PRL quartiles ranged from 6.9 ng/ml to 13 ng/ml in men and 9.6 ng/ml to 15.8 ng/ml in women. Type 2 diabetes was defined variably using self-reported physician’s diagnosis, fasting blood glucose, oral glucose tolerance test or glycated hemoglobin (HbA1C). In cross-sectional studies, compared to individuals in the highest PRL groups (reference), those in the lowest PRL groups had greater risk of type 2 diabetes both in men: odds ratio (OR) and 95% confidence interval = 1.86 (1.56–2.22) and in women: OR = 2.15 (1.63–2.85). In cohort studies, women showed a significant association between low PRL and type 2 diabetes: OR = 1.52 (1.02–2.28) but not men: OR = 1.44 (0.46–4.57). Relatively low heterogeneity was observed (I2 = 25–38.4%) for cross-sectional studies, but higher for cohort studies (I2 = 52.8–79.7%). In conclusion, low PRL is associated with type 2 diabetes, but discrepancy between men and women in the relationship within cohort studies requires further research.
Optimizing resource allocation: Cost-effectiveness of specified D-dimer cut-offs in cancer patients with suspected venous thromboembolism
Authors: Biciusca Teodora , Gruenewald Leon D. , Martin Simon S. , Gotta Jennifer , Mahmoudi Scherwin , Eichler Katrin , Booz Christian , Salbach Christian , Müller-Hennessen Matthias , Biener Moritz , Yildirim Mustafa , Milles Barbara , Sommer Christof M. , Vogl Thomas J. , Giannitsis Evangelos , Koch Vitali 
Published: May 2024

AbstractAn accurate diagnosis of venous thromboembolism (VTE) is crucial, given the potential for high mortality in undetected cases. Strategic D-dimer testing may aid in identifying low-risk patients, preventing overdiagnosis and reducing imaging costs. We conducted a retrospective, comparative analysis to assess the potential cost savings that could be achieved by adopting different approaches to determine the most effective D-dimer cut-off value in cancer patients with suspected VTE, compared to the commonly used rule-out cut-off level of 0.5 mg/L. The study included 526 patients (median age 65, IQR 55–75) with a confirmed cancer diagnosis who underwent D-dimer testing. Among these patients, the VTE prevalence was 29% (n = 152). Each diagnostic strategy's sensitivity, specificity, negative likelihood ratio (NLR), as well as positive likelihood ratio (PLR), and the proportion of patients exhibiting a negative D-dimer test result, were calculated. The diagnostic strategy that demonstrated the best balance between specificity, sensitivity, NLR, and PLR, utilized an inverse age-specific cut-off level for D-dimer [0.5 + (66-age) × 0.01 mg/L]. This method yielded a PLR of 2.9 at a very low NLR for the exclusion of VTE. We observed a significant cost reduction of 4.6% and 1.0% for PE and DVT, respectively. The utilization of an age-adjusted cut-off [patient’s age × 0.01 mg/L] resulted in the highest cost savings, reaching 8.1% for PE and 3.4% for DVT. Using specified D-dimer cut-offs in the diagnosis of VTE could improve economics, considering the limited occurrence of confirmed cases among patients with suspected VTE.
Graphical Abstract
In the context of accurate diagnosis of VTE, strategic D-dimer testing helps identify low-risk patients, preventing overdiagnosis and reducing imaging costs. In our retrospective study, the diagnostic strategy that demonstrated the best balance between specificity, sensitivity, and best PLR, utilized an inverse age-specific cut-off level for D-dimer. We observed a significant cost reduction of 4.6% for PE and 1% for DVT. Abbreviations: CTPA, computed tomography pulmonary angiography; CUS, compression ultrasound; DVT, deep vein thrombosis; PE, pulmonary embolism; VTE, venous thromboembolism.
Pharmacological differences between human and mouse P2X4 receptor explored using old and new tools
Authors: Fortuny-Gomez Anna , Fountain Samuel J. 
Published: May 2024

AbstractThere is growing interest in the P2X4 receptor as a therapeutic target for several cardiovascular, inflammatory and neurological conditions. Key to exploring the physiological and pathophysiological roles of P2X4 is access to selective compounds to probe function in cells, tissues and animal models. There has been a recent growth in selective antagonists for P2X4, though agonist selectivity is less well studied. As there are some known pharmacological differences between P2X receptors from different species, it is important to understand these differences when designing a pharmacological strategy to probe P2X4 function in human tissue and mouse models. Here, we provide a systematic comparison of agonist and antagonist pharmacology in 1321N1 cells expressing either human or mouse P2X4 orthologues. We identify a rank order of agonist potency of ATP > 2-MeSATP > αβmeATP = BzATP > CTP = γ-[(propargyl)-imido]-ATP for human P2X4 and ATP > 2-MeSATP = CTP > ATPγS = γ-[(propargyl)-imido]-ATP = BzATP for mouse. Human P2X4 is not activated by ATPγS but can be activated by αβmeATP. We identify a rank order of antagonist potency of BAY-1797 = PSB-12062 = BX-430 > 5-BDBD > TNP-ATP = PPADS for human P2X4 and BAY-1797 > PSB-12062 = PPADS > TNP-ATP for mouse. Mouse P2X4 is not antagonised by 5-BDBD or BX-430. The study reveals key pharmacological differences between human and mouse P2X4, highlighting caution when selecting tools for comparative studies between human and mouse and ascribing cellular responses of some commonly used agonists to P2X4.
Review of Vibration Analysis and Structural Optimization Research for Rotating Blades
Authors: Zhong Saifeng , Jin Guoyong , Chen Yukun , Ye Tiangui , Zhou Tuo 
Published: May 2024

Abstract
Blades are important parts of rotating machinery such as marine gas turbines and wind turbines, which are exposed to harsh environments during mechanical operations, including centrifugal loads, aerodynamic forces, or high temperatures. These demanding working conditions considerably influence the dynamic performance of blades. Therefore, because of the challenges posed by blades in complex working environments, in-depth research and optimization are necessary to ensure that blades can operate safely and efficiently, thus guaranteeing the reliability and performance of mechanical systems. Focusing on the vibration analysis of blades in rotating machinery, this paper conducts a comprehensive literature review on the research advancements in vibration modeling and structural optimization of blades under complex operational conditions. First, the paper outlines the development of several modeling theories for rotating blades, including one-dimensional beam theory, two-dimensional plate–shell theory, and three-dimensional solid theory. Second, the research progress in the vibrational analysis of blades under aerodynamic loads, thermal environments, and crack factors is separately discussed. Finally, the developments in rotating blade structural optimization are presented from material optimization and shape optimization perspectives. The methodology and theory of analyzing and optimizing blade vibration characteristics under multifactorial operating conditions are comprehensively outlined, aiming to assist future researchers in proposing more effective and practical approaches for the vibration analysis and optimization of blades.
Jewish Women, Native-Born and Migrants, in Brussels: Social Integration, “Bubbles” and Acculturation
Authors: Lev Ari Lilach , Tzadik Efrat 
Published: May 2024

AbstractThe purpose of this study is to compare two groups of Jewish women, native-born and migrants, who reside in Brussels regarding their social integration into native-born Jewish and non-Jewish communities and the acculturation strategies they employ. It seems that Brussels is not as socially and culturally open, as perceived by the interviewees. Hence, the social networks of women in our study, as well as their acculturation patterns, differ in degree of separation between native-born Jewish women, non-Israeli immigrants and Israeli immigrants. The former maintain social networks characterized by fluid boundaries between them and the majority society, whereas non-Israeli immigrants are characterized by shared, not very dense networks with the native-born Jewish community and diasporic networks. Finally, Israeli women are characterized by almost completely closed social networks, which can be defined as a distinct “Israeli bubble.” As for their acculturation strategies, native-born women are those who are more integrated among non-Jews and native-born Jews, as expected from their familiarity with the culture and their long-term interactions, despite being partially marginalized as minority. Migrant women are less integrated and more separated from both native-born Jews and – to a larger extent – from non-Jews; so are Israelis. Social networks which gradually become communities are mainly created by women and maintained by them over the years. Therefore, the study of social networks, their structure and construction through daily interactions, and their contribution to the ethnic-diasporic community building have become the source of women’s strength in the host country – as immigrants and as a native-born minority group.
Predictive Partly Conditional Models for Longitudinal Ordinal Outcomes with Application to Alzheimer’s Disease Progression
Authors: Neal Jacquelyn E. , Zhang Panpan , Liu Dandan 
Published: May 2024

AbstractAssessing time-dependent risk factors in relation to the risk of disease progression is challenging, yet important, especially for chronic diseases with slow progression. In this paper, the partly conditional model is extended for characterizing disease progression at time t with longitudinal ordinal outcomes in the presence of time-dependent covariates at time s$$(s < t)$$

(
s
<
t
)

and time-dependent effects. Advantages of the method include direct modeling of disease progression, use of longitudinal risk factors, and flexibility in target period of progression $$u = t - s$$

u
=
t
-
s

. A generalized estimating equation approach is adopted for parameter estimation, and a new regularity condition requiring a fixed prediction time window $$u_0$$

u
0

is established to consistently estimate the covariance of the estimated parameters. Extensive simulation studies are conducted to assess the properties of the proposed model alongside with an explicit demonstration of the implementation using existing statistical software. The proposed method is applied to a longitudinal Alzheimer’s disease dataset from the National Alzheimer’s Coordinating Center to assess effect of time-dependent cognitive complaint on Alzheimer’s Disease progression.
Effect of American genomic ancestry on severe toxicities in children with acute lymphoblastic leukemia in the Amazon region
Authors: Wanderley Alayde Vieira , de Moraes Francisco Cezar Aquino , da Costa Nunes Giovanna Gilioli , Pereira Esdras Edgar Batista , Leitão Luciana Pereira Colares , de Oliveira Marcelo Braga , Tavares Ágatha Tereza Miranda , da Costa Pantoja Laudreisa , Khayat Bruna Cláudia Meireles , Fernandes Marianne Rodrigues , de Assumpção Paulo Pimentel , dos Santos Ândrea Kely Ribeiro , Burbano Rommel Mario Rodríguez , dos Santos Sidney Emanuel Batista , Ribeiro Raul , Khayat André Salim , dos Santos Ney Pereira Carneiro 
Published: May 2024

Abstract
Background
Acute Lymphoblastic Leukemia (ALL) is a neoplasm of the hematopoietic system characterized by a clonal expansion of abnormal lymphocyte precursor cells. ALL is the most common form of cancer in children, but despite advances in treatment, it can still be fatal. Ethnic differences influence survival rates, and genomic ancestry plays an important role, especially in mixed-race populations such as Latin America. This study aims to analyze the influence of genomic ancestry on toxicity in children with ALL in the Amazon region.

Methods
The study included 171 patients (protocol number 119,649/2012—Ethics Committee) with ALL treated at a pediatric treatment center in Belém do Pará, in the Brazilian Amazon. The patients were submitted to the BFM protocol of induction therapy for ALL. Toxicity was assessed based on laboratory tests and adverse events, classified according to the CTC-NCI guide. Genomic ancestry was determined using autosomal informative markers.

Results
The majority of children (94.74%) developed some type of toxicity during treatment, 87.04% of which were severe. Infectious toxicity was the most common, present in 84.8% of cases, 77.24% of which were severe. Amerindian ancestry showed an association with the risk of severe general toxicity and severe infectious toxicity, with a contribution of 35.0% demonstrating a significant increase in risk. In addition, post-induction refractoriness and relapse were also associated with an increased risk of death.

Conclusion
This study highlights the influence of Amerindian genomic ancestry on response to therapy and toxicity in children with ALL in the Amazon region. Understanding these associations can contribute to personalizing treatment and improving clinical outcomes.
Artificial intelligence assisted diagnosis of early tc markers and its application
Authors: Zhang Laney , Wong Chinting , Li Yungeng , Huang Tianyi , Wang Jiawen , Lin Chenghe 
Published: May 2024

AbstractThyroid cancer (TC) is a common endocrine malignancy with an increasing incidence worldwide. Early diagnosis is particularly important for TC patients, because it allows patients to receive treatment as early as possible. Artificial intelligence (AI) provides great advantages for complex healthcare systems by analyzing big data based on machine learning. Nowadays, AI is widely used in the early diagnosis of cancer such as TC. Ultrasound detection and fine needle aspiration biopsy are the main methods for early diagnosis of TC. AI has been widely used in the detection of malignancy in thyroid nodules by ultrasound images, cytopathology images and molecular markers. It shows great potential in auxiliary medical diagnosis. The latest clinical trial has shown that the performance of AI models matches with the diagnostic efficiency of experienced clinicians, and more efficient AI tools will be developed in the future. Therefore, in this review, we summarized the recent advances in the application of AI algorithms in assessing the risk of malignancy in thyroid nodules. The objective of this review was to provide a data base for the clinical use of AI-assisted diagnosis in TC, as well as to provide new ideas for the next generation of AI-assisted diagnosis in TC.
MiR-6839-5p inhibits cell proliferation, migration and invasion; a possible correlation with the suppressing VEGFA expression in human chondrosarcoma cells
Authors: Li Fusheng , Xu Jia , Zhu Yue 
Published: May 2024

AbstractMicroRNAs play an important role in the proliferation, invasion, and metastasis of malignancy. In previous studies (detailed in our previous paper), the expression of miR-6839-5p was significantly increased in SW1353 cells after 125I seed 6 Gy irradiation, which indicated miR-6839-5p may play a tumor suppression function in chondrosarcoma cells. This study aimed to identify the effects of miR-6839-5p on the human chondrosarcoma cells, and investigate the potential target genes of miR-6839-5p. Firstly, chondrosarcoma cells (SW1353 and CAL78) were transfected with hsa-miR-6839-5p specific mimic. Secondly, Cell viability assay (MTT assay), Colony formation assay, Wound healing assay, Transwell assay, TUNEL staining and Western blotting experiments were performed, and the results proved miR-6839-5p can inhibit chondrosarcoma cells proliferation, migration and invasion. Meanwhile, miR-6839-5p significantly down-regulated apoptosis facilitator Bcl-2 expression, and promoted apoptosis of chondrosarcoma cells. It is reasonable to speculate miR-6839-5p might downregulate Bcl-2 expression to induce apoptosis in SW1353 human chondrosarcoma cells. Lastly, RNA extraction and bioinformatic analysis was performed on SW1353 cells transfected with hsa-miR-6839-5p specific mimic to investigate the potential target genes of miR-6839-5p. A total of 253 differentially expressed mRNA genes (105 up-regulated genes and 148 down-regulated genes) were found, and 23 differentially expressed downregulated genes were identified. Quantitative real-time polymerase chain reaction (qRT-PCR) was conducted to validate the results, which demonstrated the expression of BST2, VEGFA, FPR3 and PPARA was significantly downregulated by miR-6839-5p mimic. Furthermore, miR-6839-5p inhibitor can restore or partially restore the expression value of the above four genes. The analysis results of miRNA target gene prediction database indicated VEGFA was the most likely direct target gene of miR-6839-5p.
Laboratory investigation on inhibition of polyvinyl alcohol used for wireline coring drilling
Authors: Huang Yuming , Zheng Wenlong , Zhang Guoqi , Chen Yong , Qin Jiashuo 
Published: May 2024

AbstractTo address the problems of wall collapse, cuttings slurrying, and scaling on the inner wall of the drill pipe, which often occur in small-diameter diamond wireline core drilling, the inhibition properties of polyvinyl alcohol (PVA) was investigated, and the formulation of solids-free drilling fluid with PVA as the inhibitor were completed. PVA has the advantages of fast adsorption and easy regulation of rheological properties Firstly the inhibition effect of PVA was compared with that of common inorganic salts (sodium chloride, NaCl, potassium chloride, KCl) by bentonite dispersion test, linear swelling test, shale rolling recovery test and mud ball immersion test in this study. Then, the inhibition mechanism of PVA was analyzed with potentiometric particle size tests, Fourier transform infrared (FT-IR) and X-ray Diffraction (XRD) measurements. Based on the outstanding inhibition performance of PVA, tackifiers and filtration reducers were preferred through the compatibility test. And finally, the effects of various contaminants on the comprehensive performance of the formulated solids-free drilling fluids were evaluated. The results showed that PVA exhibited better inhibition of clay hydration and dispersion in shale recovery and linear swelling compared to NaCl and KCl, which was particularly evident in the mud ball immersion test. FT-IR and XRD tests revealed that the inorganic salts were used to replace the cations with larger radius and high degree of hydration in the clay layer by ion exchange ti achieve the effect of clay de-watering by reducing the spacing of the clay interlayer and the electrostatic repulsion between the particles. However, PVA is strongly adsorbed on the clay surface in the form of hydrogen bonds due to its unique multi-hydroxyl chain structure, forming a hydrophobic barrier to prevent water molecules from entering the clay layer, thus inhibiting the hydration and swelling of the clay. Using PVA as an inhibitor, compounded with xanthan gum, sulfonated lignite resin and sulfonated gilsonite (FT-1), the solids-free drilling fluid is promising for use in diamond wireline core drilling in complex formations.
Visible Light-Illuminated Gold Nanohole Arrays With Tunable On-Chip Plasmonic Sensing Properties
Authors: Guang Jianye , Lu Mengdi , Li Rui , Wang Chen , Lin Ming , Fan Ruizhi , Peng Wei 
Published: May 2024

AbstractSince the discovery of the extraordinary optical transmission phenomenon, nanohole arrays have attracted much attention and been widely applied in sensing. However, their typical fabrication process, utilizing photolithographic top-down manufacturing technologies, has intrinsic drawbacks including the high costs, time consumption, small footprint, and low throughput. This study presented a low-cost, high-throughput, and scalable method for fabricating centimeter-scale (1×2 cm2) nanohole arrays using the improved nanosphere lithography. The large-scale close-packed polystyrene monolayers obtained by the hemispherical-depression-assisted self-assembly method were employed as colloidal masks for the nanosphere lithography, and the nanohole diameter was tuned from 233 nm to 346 nm with a fixed period of 420 nm via plasma etching. The optical properties and sensing performance of the nanohole arrays were investigated, and two transmission dips were observed due to the resonant coupling of plasmonic modes. Both dips were found to be sensitive to the surrounding environment, and the maximum bulk refractive index sensitivity was up to 162.1 nm/RIU with a 233 nm hole diameter. This study offered a promising approach for fabricating large-scale highly ordered nanohole arrays with various periods and nanohole diameters that could be used for the development of low-cost and high-throughput on-chip plasmonic sensors.
From sums of divisors to partition congruences
Authors: Merca Mircea 
Published: May 2024

AbstractLet z be a complex number. For any positive integer n it is well known that the sum of the zth powers of the positive divisors of n can be computed without knowing all the divisors of n, if we take into account the factorization of n. In this paper, we rely on the integer partitions of n in order to investigate computational methods for $$\sum _{d|n} (\pm 1)^{d+1}\,d^z$$

∑

d
|
n

(
±
1
)

d
+
1

d
z

, $$\sum _{d|n} (-1)^{n/d+1}\,d^z$$

∑

d
|
n

(
-
1
)

n
/
d
+
1

d
z

and $$\sum _{d|n} (-1)^{n/d+d}\,d^z$$

∑

d
|
n

(
-
1
)

n
/
d
+
d

d
z

. To compute these sums of divisors of n, it is sufficient to know the multiplicity of 1 in each partition involved in the computational process. Our methods do not require knowing the divisors of n or the factorization of n. New congruences involving Euler’s partition function p(n) are experimentally discovered in this context.