bluuebunny/crossref_metadata_2025_split huggingface dataset:
КОНЦЕПТУАЛЬНІ ПОЛОЖЕННЯ ЗАБЕЗПЕЧЕННЯ СТАЛОГО РОЗВИТКУ ПІДПРИЄМСТВ
Authors: Токмакова І. В. , Курилович В. Р. , Казаков А. Г. 
Published: May 2024

Загострення кризових явищ в економіці, обумовлених зростанням впливу негативних і деструктивних факторів соціально-економічного середовища, вказує на актуальність розбудови українських підприємств на засадах сталого розвитку.Встановлено, що сталий розвиток на рівні підприємства – це підхід до управління бізнесом, заснований на створенні довгострокової цінності для широкої групи стейкхолдерів, що включає серед інших майбутні покоління, та реалізується шляхом збалансованого управління економічними, екологічними і соціальними факторами.З’ясовано переваги сталої діяльності підприємств, серед яких слід виділити підвищення рівня організаційного управління та соціальної відповідальності, нові ринкові можливості та зростання інвестиційної привабливості, інноваційність у виробничих та управлінських процесах, мінімізація ризиків та скорочення витрат, а також створення сприятливих умов для розвитку майбутніх поколінь за рахунок раціонального розподілу і використання ресурсів. Встановлено, що існує ряд обмежень, які не дозволяють забезпечити реалізацію цільових установок сталого розвитку, зокрема це надмірна ідеологізація даної концепції. Зроблено висновок, що все більшого значення набуває необхідність реалізації практичного інструментарію сталого розвитку на базовому рівні його впровадження – підприємстві. З’ясовано, щомеханізм сталого розвитку підприємства повинен містити систему цілей, завдань, функцій, принципів та методів, що визначають внутрішню організацію та задають порядок взаємодії та напрямки впливу механізму. Розкрито ключові принципи ефективної реалізації сталого розвитку бізнесу. Виходячи з переваг системносинергетичного підходу запропоновано етапи забезпечення сталого розвитку підприємства. Визначено переваги розвитку цифрових технологій в системі сталої виробничо-господарської діяльності, зокрема це підвищення операційної ефективності, зниження екологічних ризиків, підвищення соціальної справедливості та забезпечення ефективності управлінських процесів. Приведено перспективні стратегії забезпечення сталого розвитку для українських підприємств.
An exploratory study of the relationship between pulse transit time and blood pressure based on causal inference
Authors: Song Xinyue , Ding Xiaorong 
Published: May 2024

Aim: We propose to examine the causal relationship between the noninvasive features represented by pulse transit time (PTT) and blood pressure (BP), with the aim of mitigating the impact of confounding factor(s) and thus improving the performance of BP estimation.
Methods: We identified the causal graph of BP and the important noninvasive features extracted from electrocardiogram (ECG) and photoplethysmogram (PPG) via fast causal inference (FCI) algorithm, with the orientations of the edges in the causal graph being determined by the causal generative neural networks (CGNN) algorithm. With the knowledge obtained from the causal graph, we further used hierarchical regression model to estimate BP, and validated the proposed method on 17 subjects.
Results: We found that the obtained causal graph was almost consistent with the prior knowledge, and heart rate (HR) was one of the main confounding factors of PTT and BP. Incorporating HR into the hierarchical regression model to eliminate its confounding effect on the PTT-based BP estimation, the mean value of SBP and DBP estimation was improved by 1.27 and 1.89 mmHg, respectively, and the mean absolute difference (MAD) was improved by 2.28 and 3.60 mmHg, respectively.
Conclusion: Causal inference-based method has the potential to clarify the causal relationship between BP and related wearable noninvasive features, which can further shed light on developing new methods for cuffless BP with acceptable accuracy.
The Impact of Patient Education on Inpatient Fall Risk
Authors: Modica Anthony , Bitterman Adam D. 
Published: May 2024

» Patient falls in the hospital are one of the leading sentinel events identified by the Joint Commission.» Hospital falls affect orthopaedic patients of older age at higher rates, and up to 34% of falls lead to injury such as fractures.» Patients often misperceive their fall risk, and modalities aimed at educating patients to address the incongruence between perceived and actual fall risk significantly reduce fall rate and injurious fall rate.» Adequate communication with patients and their families with the goal of educating them may diminish the physical, psychological, and emotional detriment to orthopaedic patients.
WITHDRAWN: The effect of a group counselling program to reduce the level of future anxiety and psychological stress among gifted students
Authors: Mahasneh Ahmad M. , Mhaiat Fatin A. , Abood Mohammad H. 
Published: May 2024

Abstract

The full text of this preprint has been withdrawn by the authors while they make corrections to the work. Therefore, the authors do not wish this work to be cited as a reference. Questions should be directed to the corresponding author.
WITHDRAWN: Mathematical Analysis of the Dynamics of Lumpy Skin Epidemics within Delay Differential Equations
Authors: Fadhal Emad , Raza Ali , Baleanu Dumitru , Naveed Muhammad , Defterli Ozlem , Rafiq Muhammad , Ahmed Nauman 
Published: May 2024

Abstract

The full text of this preprint has been withdrawn by the authors due to author disagreement with the posting of the preprint. Therefore, the authors do not wish this work to be cited as a reference. Questions should be directed to the corresponding author.
Pseudomonas putida A (ATCC 12633) produces polyhydroxyalkanoates as by products during the degradation of synthetic ammonium compounds commonly found in wastewater
Authors: Heredia Romina , Liaudat Ana Cecilia , Liffourrena Andrés Sebastián , Boeris Paola Sabrina 
Published: May 2024

Abstract

Purpose
Assess to production of polyhydroxyalkanoates (PHAs) by Pseudomonas putida A (ATCC 12633), when it degraded the pollutant tetradecyltrimethylammonium bromide (TTAB), a synthetic quaternary ammonium compound (QAC) commonly present in wastewater. Our ultimate purpose is to develop sustainable strategies to convert waste products into high value-added products, like PHAs.
Methods
P. putida was cultivated in the presence of preferred carbon and nitrogen sources or solely with TTAB as a carbon and nitrogen source. PHAs presence was examined through TEM, fluorescence microscopy, and flow cytometry and quantified using gravimetric techniques. Constituent monomers were identified via GC-MS. qRT-PCR assays were performed to pinpoint genes implicated in PHAs synthesis and degradation.
Results
Maximum accumulation (52% of the dry cell weight) was achieved at 48 h of cultivation with TTAB. The accumulated PHAs were medium-chain-length: methyl 3-hydroxy-decanoate (65.1%), methyl 3-hydroxy-octanoate (11.9%), methyl 3-hydroxy-dodecanoate (8.4%), and methyl 3-hydroxy-tetradecanoate (14.6%). Regarding the relative expression levels of genes involved in PHA polymerization/depolymerization, those of phaC1 peaked at 48 h, but those of phaZ were detectable only after 72 h.
Conclusion
P. putida’s ability to remove a QAC and produce PHAs as a result makes it a promising candidate for the biotechnological conversion of waste into valuable biopolymers.
Prevalence of molar incisor hypomineralization and demands for treatment according to the severity of its clinical manifestation.
Authors: Guerra Bianca Mattos Santos , Jorge Roberta Costa , Reis Patrícia Papoula Gorni dos , Machado Gabriella de Freitas , Fidalgo Tatiana Kelly da Silva , Soviero Vera Mendes 
Published: May 2024

Abstract

Aim Assess the prevalence and severity of molar incisor hypomineralization (MIH) in children 6- to 12-year-old and correlate MIH severity with the complexity of treatment demands.Materials and methods Between March and October 2023, 2,136 children were screened for MIH by two calibrated examiners. MIH severity was categorized in mild, moderate, severe, and very severe. Treatment requirements were categorized in basic, intermediate, and complex.Results The prevalence of MIH was 15.5% (n = 331). Among the 126 children with atypical caries/restoration, cusp involvement was observed in 60.3%, endodontic treatment was necessary in 24.6%, only 15% needed restorations limited to two tooth surfaces with no cusp involvement. Extraction due to MIH was observed in 2.7%.Conclusion The prevalence of MIH was in accordance with previous literature. Whenever a restorative treatment was necessary, it often involved multiple tooth surfaces and cusps. The complexity of treatment demands increased with age. It is necessary that oral health policymakers pay special attention to children with MIH to ensure appropriate treatment.
Sustainable Organizational Adaptation: Private Higher Education's Response to COVID-19 Challenges
Authors: Ramachandaran Sharmila , Badwy Hanan Eid 
Published: May 2024

Abstract

This study analyses organizational development and change approaches in private higher education institutions (HEIs) in response to COVID-19 encounters. Through case studies and stakeholder interviews, it pinpoints four key factors: organizational adaptation, faculty role redefinition, digital transformation, and sustainability. Remarkably, sustainability emerges as a critical aspect, integrating environmental, social, and economic considerations into strategies. These include lowering environmental impact, fostering social equity, and safeguarding economic resilience. The study highlights the importance of understanding HEIs' responses to crises and their effect on organizational development. The understandings of the study can inform policymakers and administrators, enhancing crisis management and organizational strategies for greater resilience. By assimilating sustainability into these strategies, HEIs can align with global agendas like the UN Sustainable Development Goals, contributing to a more sustainable future for higher education.
Effects of heat stress on production performance and protein metabolism of skeletal muscle in meat rabbits
Authors: Liu Gongyan , Liu Ce , Sun Haitao , Bai Liya , Yang Liping , Zhang Yin , Gao Shuxia 
Published: May 2024

Abstract

In modern animal husbandry production, rabbits are readily affected by heat stress in summer. A critical issue in rabbit production is to determine the mechanism by which heat stress prevents muscle growth. The purpose of this experiment was to study the effects of heat stress on performance and protein metabolism of skeletal muscle in meat rabbits. A total of 160 New Zealand White rabbits aged 80 days with mean initial body weights of 2359 ± 200 g were randomly divided into the control group and heat stress group. The experiment duration was 20 days. Heat stress treatment reduced the growth performance and slaughter performance of the rabbits (P < 0.05), and increased muscle yellowness (b*, P < 0.05). In addition, heat stress treatment increased the concentrations of leptin, cholesterol, high-density lipoprotein (HDL) cholesterol, and low-density lipoprotein (LDL) cholesterol in serum (P < 0.05), and decreased the serum total protein and immunoglobulin (IgG, IgM, and IgA) contents of rabbits. Under the criteria fold-change ≥ 1.20 or ≤ 0.84 and P-value ≤ 0.05, seven up-regulated proteins and 122 down-regulated proteins were screened. A gene ontology (GO) enrichment analysis of the differentially expressed proteins was performed. The most enriched specific GO terms among the differential proteins were response to stress, extracellular region, and protein binding in the biological process, cellular component, and molecular function categories, respectively, and the most enriched pathway was PI3K/Akt signalling pathway. Heat stress reduced the carcass yield of growing meat rabbits, changed the physical characteristics of the skeletal muscle, influenced protein metabolism by changing blood indices potentially through the PI3K/Akt signalling pathway.
Peripherally inserted central venous catheter in outpatient antibiotic spinal infection treatment is safe, effective and leads to significant reduction in healthcare expenses
Authors: Bonk Maximilian-Niklas , Sommer Björn , Krauß Philipp E. , Maurer Christoph , Simon Valeska , Berlis Ansgar , Hofmann Reinhard , Shiban Ehab 
Published: May 2024

Abstract

Introduction: Prolonged antibiotic therapy is often recommended for the treatment of spinal infections. This study aimed to evaluate the efficacy and safety of outpatient intravenous (IV) antibiotic therapy for spinal neurosurgery patients with spondylodiscitis.
Methods: We carried out a retrospective study involving 67 patients who were administered peripherally inserted central catheter (PICC) for IV antibiotic treatment from January 2020 to December 2022. We assessed patient data concerning infections and neurosurgical concerns. Each patient underwent a minimum of 6 weeks of IV antibiotics, both as inpatients and outpatients.
Results: The study included 67 patients with a median age of 61 years (SD +/- 14.18 years), with approximately 44% being female. The average hospital stay for inpatient treatment was 20 days (SD +/- 8.8 days). Subsequent outpatient antibiotic therapy lasted an average of 70.32 days (SD +/- 18.24 days), with outpatient IV therapy accounting for 44.74 days (SD +/- 9.15 days). The most common pathogens identified were Staphylococcus epidermidis and methicillin-sensitive Staphylococcus aureus. Microbiological analysis did not detect any pathogens in 18% of patients. Radiographic and laboratory evidence of spondylodiscitis was absent in 99% of patients during the final follow-up. No catheter-related complications occurred.
Conclusion: Outpatient IV antibiotic therapy using a PICC line catheter is a safe and effective treatment option for spinal infections, especially in elderly patients.
Assessment of National Immunization Technical Advisory Group (NITAG) functionality in selected Eastern Mediterranean countries
Authors: Parwiz Sardar , Al-gunaid Magid , Bashour Hyam , Khader Yousef , Saeed Khwaja Mir Islam , Lami Faris , Daoud Leen , Majeed Zeina Abdel , Hussain Zakir 
Published: May 2024

Abstract

National Immunization Technical Advisory Groups (NITAGs) are independent advisory committees providing evidence-based recommendations for decision-making on new vaccine introduction and immunization policy. This report, addresses issues of the functionality of the NITAGs in the selected EMR countries, building the capacity of NITAG to improve the functionality of NITAG in the targeted counties as part of EMPHNET support to health systems strengthening in the region. This assessment was conducted in 13 EMR countries Afghanistan, Algeria, Iraq, Jordan, Libya, Morocco, Oman, Qatar, Tunisia, Saudi Arabia, Sudan, Syria, and Yemen. The target population was NITAG chairperson and NITAG technical secretary (NEPI). the assessment tool was digitalized using a KoBo toolbox. Following the data analysis, a five-day inter-country workshop was conducted to provide a facility to the countries under review to develop country improvement plans to accomplish the NITAG functionality in the region. According to the findings, all of the under-review countries have active NITAG with the written terms of reference. For 41% of the respondents, the role of NITAG was not clear and they mentioned that the NITAG directly makes the policy. Based on the findings 36% of the countries don’t have SOPs for their NITAGs. Regarding the membership, all the countries mentioned that their NITAG consists of multidisciplinary experts. However, 46% of the countries faced a shortage of experts. Likewise, 69% of the countries reported high turnover of the NITAG members which negatively affects the functionality of NITAG. Based on the findings the main challenges to the NITAG included staff turnover, shortage of technical capacity, and the load on human resources. Some highlighted political or personal biases. Financial challenges were also noted in all countries except high-income countries. Only 24.5% of the participants mentioned that they documented the NITAG recommendations separately from the meeting minutes. Likewise, 59% of the participants mentioned that the NITAG uses a standardized and systematic method of searching for, reviewing, and synthesizing relevant evidence based on a PICO-like framework for the policy question. The findings of the regional assessment clearly showed that major gaps need to be tackled to ensure the functionality of NITAG. Clear TOR, SOPs, the clear and well-defined role of secretariats, and ensuring the systematic provision of the recommendation for policymakers.
Participant-reported personal utility of genetic testing for Parkinson’s disease and interest in clinical trial participation
Authors: Verbrugge Jennifer , Oas Hannah , Cook Lola , Schwantes-An Tae-Hwi , Walsh Laurence , Wills Anne , Mata Ignacio , Nance Martha , Beck James , Naito Anna , Marder Karen , Alcalay Roy 
Published: May 2024

Abstract

Genetic testing for Parkinson’s disease (PD) is infrequently performed in clinical settings due to providers’ perception of low utility, yet patients may find the results useful. We investigated the reported personal utility of genetic testing for PD as part of the PD GENEration study, in which genetic testing and counseling are provided at no cost to participants. We also investigated how genetic test results may encourage enrollment in additional research studies. In the PD GENEration study, PwP underwent genetic testing for seven genes associated with PD and received genetic counseling to discuss results. Participants (n=972) completed a survey examining the perceived personal utility of their results and interest in participating in additional research studies. Most participants found their genetic test results useful in several ways, including satisfying their curiosity (81% of participants), feeling good about helping the medical community (80%), and having information to share with family (77%). There were no significant differences in perceived personal utility between gene-positive and gene-negative participants. Forty-five percent of all participants expressed interest in participating in additional research studies and 16% of all participants confirmed enrollment in other studies. Our results suggest that participants find personal utility in genetic testing regardless of results. Although participants may be interested in enrolling in additional research, they may need more support and resources to do so.
Study of Neutrophil CD64 and HLA-DR as Early Detection Markers of Sepsis in Hepatic ICU Patients
Authors: Elsabaawy Maha , Elazab Gasser , Khalil Fatma , Alhajajy Fatma , Awadein Mohamed , Elmaksoud Fatma Abd , Abdelkareem Mervat 
Published: May 2024

Abstract

Background
Sepsis is the commonest cause of death in liver cirrhosis patients.
Aim
Evaluation of neutrophil and monocyte CD64 and HLA-DR as early biomarkers predicting sepsis in liver cirrhosis.
Methods
This case-control study involved 70 cirrhotic patients (35 with sepsis and 35 without) and 30 healthy individuals. Laboratory studies were performed, including CD64 and HLA-DR using flow cytometry along with sepsis index (SI).
Results
Patients were mainly males (80%), aged 62.17 and 64.69 years respectively. Mono CD64% at Cut-off: >62.9 showed AUC: 0.676, Sensitivity: 80.0%, Specificity: 60.0%, PPV: 66.7%, and NPV: 75.0%. while Mono CD64 MFI at Cut-off > 9.5 shoed AUC: 0.659, Sensitivity: 94.29%, Specificity: 37.14%, PPV: 60.0%, and NPV: 86.7%. Combinations of CRP + Lactate + Mono CD64%+ Mono CD64 MFI revealed AUC: 0.929, Sensitivity: 82.86%, Specificity: 91.43%, PPV: 90.6%, and NPV: 84.2% Mono CD64% and CD64 MFI (0.003; 0.03) respectively. Regression analysis defined Mono CD64% >62.9 (OR 6), Mono CD64 MFI > 9.5 (OR 9.75), CRP > 32.4 (OR 13.5), lactate > 1.93 (OR 12.08), and ALBI score > 0.01 (OR 6) all as factors affecting early sepsis in cirrhosis.
Conclusion
Mono CD64% and Mono CD64 MFI proved efficacy as early septic biomarkers with higher efficacy when combined with traditional inflammatory markers in liver cirrhosis patients.
Pregnancy outcomes in correlation with placental histopathology in pregnancies complicated by fetal growth restriction with vs. without reduced fetal movements
Authors: Mor Liat , RABINOVITCH TAMAR , Schreiber Letizia , Paz Yael Ganor , Barda Giulia , Kleiner Ilia , Weiner Eran , Levy Michal 
Published: May 2024

Abstract

Purpose: Fetal movements are crucial indicators of fetal well-being, with reduced fetal movements (RFM) suggesting potential fetal compromise. Fetal growth restriction (FGR), often linked to placental insufficiency, is a major cause of perinatal morbidity and mortality. This study aimed to investigate the neonatal, labor, and placental outcomes of FGR pregnancies with and without RFM at term.
Methods: In this retrospective study, data from all term, singleton deliveries with FGR and concomitant RFM were obtained and compared to an equal control group of FGR without RFM. Maternal characteristics, pregnancy and neonatal outcomes, and placental histology were compared. The primary outcome was a composite of adverse neonatal outcomes. A multivariable regression analysis was performed to identify independent associations with adverse neonatal outcomes.
Results: During the study period, 250 FGR neonates with concomitant RFM and an equal control group were identified. The groups did not differ in maternal demographics aside from significantly higher rates of maternal smoking in the RFM group (p<0.001). Polyhydramnios and oligohydramnios (p=0.032 and p=0.007, respectively) and meconium-stained amniotic fluid (p<0.001) were more prevalent in the FGR+RFM group. Additionally, the RFM group showed higher rates of adverse neonatal outcomes despite having larger neonates (p=0.047 and p<0.001, respectively). No significant differences were observed in placental findings. Logistic regression identified RFM as an independent predictor of adverse neonatal outcomes (aOR 2.45, 95%CI 1.27-4.73, p=0.008).
Conclusion: Reduced fetal movements are significant and independent predictors of worse neonatal outcomes in FGR pregnancies, suggesting an additional acute insult on top of underlying placental insufficiency.
Non-linear dose-response relationship between serum albumin and acute kidney injury in sepsis patients: a cohort study
Authors: Liang Xiaomin , Hu Haofei , Chen Xinglin , Zhou Yan , Li Guiyun , Wen Sha , Mei Jiang , Zhang Lin , Gui Shuiqing , Li Ying 
Published: May 2024

Abstract

Background
The role of serum albumin on acute kidney injury (AKI) remains controversial. Additionally, research on this relationship in sepsis patients is sparse. Therefore, this research aimed to investigate the relationship between serum albumin level and probability of AKI in patients with sepsis.
Methods
This study was a retrospective cohort analysis of sepsis patients across the United States between 2014 and 2015 in the eICU Collaborative Research Database (eICU-CRD). To estimate the role of albumin on AKI by univariate, multivariate logistic regression and smooth curve fitting analysis.
Results
Among 5459 patients with sepsis, 32.94% (1798 patients) developed AKI. The results of the multivariate logistic regression analysis indicated that the albumin and AKI were negatively correlated (adjusted OR = 0.87, 95% CI 0.77–0.98, P = 0.0199). Moreover, a nonlinear relationship was observed between albumin level and probability of AKI with a inflection point at 2.1 g/dL. For albumin level < 2.1g/dL, each unit increase in serum albumin reduced the probability of AKI by 39% (adjusted OR = 0.61; 95% CI 0.44–0.85; P = 0.0032). However, for albumin levels above 2.1 g/dL, there was no significant association with the probability of AKI (adjusted OR = 0.99, 95% CI 0.83–1.16; P = 0.8691).
Conclusion
Serum albumin level below 2.1g/dL was defined as a risk factor for AKI in sepsis patients.