bluuebunny/crossref_metadata_2025_split huggingface dataset:
Proteomics Approach to Identify Serum Biomarkers Associated with
Gastric Cancer in South Indian Tamils
Authors: Chithra Madhesh Jeevitha , Narasiman Manojkumar , Nagarajan Vignesh , S Meenalosani , Varshikaa Sweta , Sivagnanam Ananthi , Jayaraman Megala 
Published: May 2024

Background::
Identifying cancer-specific biomarkers is a crucial step in the disease
screening process at a very early stage of tumor development. In recent years, Quantitative proteomic
approaches have gained importance in identifying novel candidate markers in cancer.
Gastric cancer has always been known as a life-threatening medical condition with high mortality
rates.

Objectives::
The objective of our research is to adapt serum samples from Indian gastric cancer
patients to identify and understand the differentially regulated proteins in comparison with
healthy individuals.

Methods::
A total of 30 serum isolates from gastric cancer patients and healthy individuals were
obtained and subjected to 2-D Gel electrophoresis, and Tandem LC-MS analysis revealed 12
differentially expressed protein spots. The functional properties of identified proteins were further
analyzed using PANTHER and STRING databases.

Results::
The differentially expressed protein spots were identified as three candidate proteins:
Haptoglobin, Prohibitin, and Apolipoprotein. The protein interaction studies reveal that the haptoglobin
fragments were upregulated, and the remaining two prohibitin and Apolipoprotein
were down-regulated in gastric cancer patients.

Conclusion::
All the proteins identified as biomarkers were found to be involved in regulating
cell proliferation and stabilization of oxidative metabolism in the liver; therefore, differential
regulation plays a crucial role in gastric cancer progression.
Disposition Kinetics of Cathinone and its Metabolites after Oral Administration in Rats
Authors: Sabei Fahad Y. , Khardali Ibrahim , Al-Kasim Mohamed A. , Shaheen Emad Sayed , Oraiby Magbool , Alamir Ahmad , David Banji , Alshahrani Saeed , Jali Abdulmajeed M. , Attafi Mohammed , Albeishy Mohammed Y. , Attafi Ibraheem 
Published: May 2024

Background:
Cathinone is a natural stimulant found in the Catha edulis plant. Its derivatives make
up the largest group of new psychoactive substances. In order to better understand its effects, it is imperative
to investigate its distribution, pharmacokinetics, and metabolic profile. However, the existing literature on
cathinone remains limited.

Objective:
This study aimed to investigate the disposition kinetics and metabolic profile of cathinone and its
metabolite cathine through a single oral dose of cathinone administration in rats.

Methods:
Cathinone and cathine concentrations were identified and quantified using ion trap liquid chromatography-
mass spectrometry (LC-IT/MS). The metabolic profile in the serum, brain, lung, liver, kidney, and heart
was analyzed at specific time points (0, 0.5, 2.5, 6, 12, 24, 48, and 72 hours) using the ultra-high performance
liquid chromatography-quadrupole time-of-flight mass spectrometry (UPLC-QTOF/MS) method.

Results:
The highest concentration of cathinone was found in the kidney (1438.6 μg/L, which gradually decreased
to 1.97 within 48 h and disappeared after 72 h. Cathinone levels in the lungs, liver, and heart were
859, 798.9, and 385.8 μg/L, respectively, within half an hour. However, within 2.5 hours, these levels decreased
to 608.1, 429.3, and 309.1 μg/L and became undetectable after 24 h. In the rat brain, cathinone levels
dropped quickly and were undetectable within six hours, decreasing from 712.7 μg/L after 30 min. In the brain
and serum, cathine reached its highest levels at 2.5 hours, while in other organs, it peaked at 0.5 hours, indicating
slower conversion of cathinone to cathine in the brain and serum.

Conclusion:
This study revealed a dynamic interplay between cathinone disposition kinetics and its impact on
organ-specific metabolic profiles in rats. These results have significant implications for drug development,
pharmacovigilance, and clinical practices involving cathinone. Investigating the correlation between the
changes in biomarkers found in the brain and the levels of cathinone and cathine is essential for informed decision-
making in medical practices and further research into the pharmacological properties of cathinone.
Stimuli-sensitive Chitosan-based Nanosystems-immobilized Nucleic Acids
for Gene Therapy in Breast Cancer and Hepatocellular Carcinoma
Authors: Naghib Seyed Morteza , Ahmadi Bahar , Mozafari M. R. 
Published: May 2024

Abstract:
Chitosan-based nanoparticles have emerged as a promising tool in the realm of cancer
therapy, particularly for gene delivery. With cancer being a prevalent and devastating disease, finding
effective treatment options is of utmost importance. These nanoparticles provide a unique solution
by encapsulating specific genes and delivering them directly to cancer cells, offering immense
potential for targeted therapy. The biocompatibility and biodegradability of chitosan, a naturally
derived polymer, make it an ideal candidate for this purpose. The nanoparticles protect the genetic
material during transportation and enhance its cellular uptake, ensuring effective delivery to
the site of action. Furthermore, the unique properties of chitosan-based nanoparticles allow for the
controlled release of genes, maximizing their therapeutic effect while minimizing adverse effects.
By advancing the field of gene therapy through the use of chitosan-based nanoparticles, scientists
are making significant strides toward more humane and personalized treatments for cancer patients.
Nonsurgical Minimally Invasive Endodontic Treatment of Large Periapical Lesions: A Report of Three Cases
Authors: Van Le Hong , Trinh Vu Hai , Vu Thai Son , Nguyen Tuan Anh 
Published: May 2024

Introduction
Periapical lesions develop as a result of microorganisms from necrotic pulp tissue or retained foreign bodies in the periapical tissue, leading to acute or chronic inflammation. It has been proven that the majority of inflammatory periapical lesions can be effectively treated using nonsurgical endodontic management. However, the selection between surgical and nonsurgical endodontic treatment for managing large periapical lesions remains a controversial issue. This report aims to reveal the effectiveness of nonsurgical, minimally invasive endodontic treatment for large periapical lesions in conjunction with lesion decompression and aspiration.

Case Presentation
This article presents three cases with large periapical lesions related to severe bone destruction with different causes that were managed with nonsurgical endodontic treatment, involving multiple visits for intracanal medication with calcium hydroxide. In all three cases, the long-term clinical assessments and CBCT scans consistently showed complete healing. The follow-up period ranged from 24 to 48 months.

Conclusion
The successful results demonstrated the efficacy of nonsurgical endodontic management, which is a minimally invasive approach when addressing large inflammatory periapical lesions with diverse causes.
Impulsivity: A Transdiagnostic Approach to Understanding Adolescent Substance Use
Authors: Lamichhane Bishal , Li Zishen , Sabharwal Ashutosh , Moukaddam Nidal 
Published: May 2024

Background:
Impulsivity, characterized by the tendency to act on
impulse without consideration for consequences, has been implicated in health
disorders such as problematic substance use among adolescents. Understanding
impulsivity's nature, clinical manifestations, quantification, and management in a
clinical context could help address underlying disorders.

Methods:
We reviewed previous studies where different impulsivity dimensions
were identified and explored the manifestations of impulsivity across conditions
characterized by high impulsivity. Similarly, we pursued a literature search on
various factors influencing impulsivity, methods employed to quantify them, and
commonly used treatments for impulsivity control.

Results:
The multidimensional and transdiagnostic nature of impulsivity was
acknowledged across several studies. Various health disorders such as substance
use disorders, borderline personality disorder, and attention-deficit/hyperactivity
disorder implicated impulsivity, even among the adolescent groups. We identified
biological, psychological, and environmental factors influencing impulsivity. We
also present the commonly employed approaches to quantifying impulsivity and
new measurement approaches under active investigation that are relevant in
characterizing impulsivity in adolescents. Treatment options to manage
impulsivity were also reviewed and are presented in this work.

Conclusion:
This work offers a comprehensive understanding of impulsivity as
one of the underlying factors in adolescent substance use and related health
disorders, emphasizing factors affecting impulsivity, approaches for
measurement, and implications of high impulsivity on mental health and
behaviors.
Physician and Practice Characteristics Influencing Telemedicine Uptake Among Frontline Clinicians in the Early COVID-19 Pandemic Response: National Survey Study
Authors: Hamline Michelle Y , Xing Guibo , Kravitz Richard L , Miller Marykate , Melnikow Joy 
Published: May 2024

Background
Telemedicine expanded rapidly during the COVID-19 pandemic, as key policy changes, financial support, and pandemic fears tipped the balance toward internet-based care. Despite this increased support and benefits to patients and clinicians, telemedicine uptake was variable across clinicians and practices. Little is known regarding physician and institutional characteristics underlying this variability.

Objective
This study aimed to evaluate factors influencing telemedicine uptake among frontline physicians in the early pandemic response.

Methods
We surveyed a national stratified sample of frontline clinicians drawn from the American Medical Association Physician Professional Data in June or July 2020. The survey inquired about the first month and most recent month (June 2020) of pandemic telemedicine use; sample data included clinician gender, specialty, census region, and years in practice. Local pandemic conditions were estimated from county-level data on COVID-19 rates at the time of survey response. Data were analyzed in a weighted logistic regression, controlling for county-specific pandemic data, and weighted to account for survey data stratification and nonresponse.

Results
Over the first 3-4 months of the pandemic, the proportion of physicians reporting use of telemedicine in >30% of visits increased from 29.2% (70/239) to 35.7% (85/238). Relative to primary care, odds of substantial telemedicine use (>30%) both during the first month of the pandemic and in June 2020 were increased among infectious disease and critical care physicians and decreased among hospitalists and emergency medicine physicians. At least minimal prepandemic telemedicine use (odds ratio [OR] 11.41, 95% CI 1.34-97.04) and a high 2-week moving average of local COVID-19 cases (OR 10.16, 95% CI 2.07-49.97) were also associated with substantial telemedicine use in June 2020. There were no significant differences according to clinician gender, census region, or years in practice.

Conclusions
Prepandemic telemedicine use, high local COVID-19 case counts, and clinician specialty were associated with higher levels of substantial telemedicine use during the early pandemic response. These results suggest that telemedicine uptake in the face of the pandemic may have been heavily influenced by the level of perceived threat and the resources available for implementation. Such understanding has important implications for reducing burnout and preparation for future public health emergencies.
Digital Interventions for Self-Management of Type 2 Diabetes Mellitus: Systematic Literature Review and Meta-Analysis
Authors: Kerr David , Ahn David , Waki Kayo , Wang Jing , Breznen Boris , Klonoff David C 
Published: May 2024

Background
The proliferation of digital technology has the potential to transform diabetes management. One of the critical aspects of modern diabetes management remains the achievement of glycemic targets to avoid acute and long-term complications.

Objective
This study aims to describe the landscape of evidence pertaining to the relative effectiveness or efficacy and safety of various digital interventions for the self-management of type 2 diabetes mellitus (T2DM), with a primary focus on reducing glycated hemoglobin A1c (HbA1c) levels.

Methods
A systematic literature review (SLR) was conducted by searching Embase, MEDLINE, and CENTRAL on April 5, 2022. Study selection, data extraction, and quality assessment were performed by 2 independent reviewers. Eligibility criteria for the SLR included randomized controlled trials (RCTs) and comparative observational studies evaluating interventions containing both human (eg, coaching) and digital components (eg, glucose meter) in adult patients with T2DM. The primary meta-analysis was restricted to studies that reported laboratory-measured HbA1c. In secondary analyses, meta-regression was performed with the intensity of coaching in the digital intervention as a categorical covariate.

Results
In total, 28 studies were included in this analysis. Most studies (23/28, 82%) used the reduction of HbA1c levels as the primary end point, either directly or as a part of a multicomponent outcome. In total, 21 studies reported statistically significant results with this primary end point. When stratified into 3 intervention categories by the intensity of the intervention supporting the digital health technology (analyzing all 28 studies), the success rate appeared to be proportional to the coaching intensity (ie, higher-intensity studies reported higher success rates). When the analysis was restricted to RCTs using the comparative improvement of HbA1c levels, the effectiveness of the interventions was less clear. Only half (12/23, 52%) of the included RCTs reported statistically significant results. The meta-analyses were broadly aligned with the results of the SLR. The primary analysis estimated a greater reduction in HbA1c associated with digital interventions compared with usual care (–0.31%, 95% CI –0.45% to –0.16%; P<.001). Meta-regression estimated reductions of –0.45% (95% CI –0.81% to –0.09%; P=.02), –0.29% (95% CI –0.48% to –0.11%; P=.003), and –0.28% (95% CI –0.65% to 0.09%; P=.20) associated with high-, medium-, and low-intensity interventions, respectively.

Conclusions
These findings suggest that reducing HbA1c levels in individuals with T2DM with the help of digital interventions is feasible, effective, and acceptable. One common feature of effective digital health interventions was the availability of timely and responsive personalized coaching by a dedicated health care professional.
A Cross-Country Analysis of Islamic Bank’s Performance in Malaysia and Indonesia
Authors: Qomar Moh. Nurul , Rusgianto Sulistya , Muttaqin Ibnu , Hidayati Athi’ 
Published: May 2024

This study aims to examine the financial performance of Islamic banks in Indonesia and Malaysia, with a specific focus on optimizing shareholder value. The assessment includes efficiency, market share, interest rates, inflation and economic growth as crucial criteria in comprehending the success of Islamic banks in each country. The secondary data is derived from the annual reports of 25 Islamic banks in Indonesia and Malaysia, with a focus on characteristics pertaining to operational efficiency and market share. Furthermore, data is obtained from Bank Indonesia (BI) to gather statistics regarding inflation, interest rates, and GDP growth from the years 2018 to 2021. The study used panel data regression with a random effects model as the most accurate estimator. The results of the panel data regression analysis suggest that inflation has a favorable effect on return on equity (ROE), while GDP growth has a beneficial impact on return on assets (ROA). This research highlights the importance of enhancing inflation risk management and making strategic adaptations to the business plans of Islamic banks in Malaysia and Indonesia. This research enhances the scholarly comprehension of the variables affecting the efficiency of Islamic banks in diverse economic conditions.
Analisis Pengaruh Tingkat Pendapatan Industri Rumah Tangga Produksi Jenang Ketan Di Desa Rejowinangun Kecamatan Kadengan Kabupaten Blitar
Authors: Triana Sari Desi , Susilowati Dwi 
Published: May 2024

Penelitian ini bertujuan untuk mengetahui pendapatan kotor produksi jenang ketan sekali proses produksi di setiap harinya dan mengetahui pengaruh modal, tenaga kerja dan bahan baku terhadap pendapatan industri rumah tangga jenang ketan di Desa Rejowinangun. Penelitian ini menggunakan jumlah sampel sebanyak 33 responden pemilik industri rumah tangga jenang ketan. Teknik yang digunakan didalam penelitian ini menggunakan analisis regresi liniear berganda dan data yang digunakan yaitu cross section. Penelitian ini mendapatkan data dengan cara wawancara langsung dan membagikan kuesioner kepada pemilik industri rumah tangga jenang ketan di Desa Rejowinangun. Hasil dari penelitian ini rata-rata pendapatan kotor industri jenang ketan yaitu Rp. 1.500.000/satu kali produksi dan hasil perhitungan analisis data tersebut menunjukan bahwa hubungan antara modal dengan nilai koefisien 1.039464, tenaga kerja dengan nilai koefies sebesar 14.45511 dan bahan baku dengan nilai koefisien 0.280612 berpengaruh positif dan signifikan terhadap pendapatan industri rumah tangga jenang ketan di Desa Rejowinangun Kecamatan Kademangan Kabupaten Blitar.
A History of the Academy of Accounting Historians: 2014–2023
Authors: Lazdowski Yvette J. , Fafatas Stephan A. , Holley Brandi L. 
Published: May 2024

ABSTRACT
This paper, the fourth in a series covering the history of the Academy of Accounting Historians (The Academy) since its founding in 1973, recounts and details the leadership, publication, activities, and events of the period 2014–2023 from the viewpoint of individuals who have served as officers, trustees, or members of The Academy. The earlier histories of The Academy appeared in this journal in December 1989 (1973–1988), December 1998 (1989–1998), and December 2014 (1999–2013) and provide a similar profile of the organization for those periods, with a summary evaluation as part of the conclusion. The Academy proudly celebrated its 50th anniversary in 2023. One of the three authors of this study was also a coauthor of the previous study.
Data Availability: Data are available from the public sources cited in the text.
JEL Classifications: M00.
Enhancing Faculty Grading Productivity Using Robotic Process Automation (RPA): The Development of a Structured Query Language (SQL) Automated Grading Tool
Authors: Coyne Joshua G. , Summers Scott L. , Wood David A. 
Published: May 2024

ABSTRACT
Using the design science methodology, we develop an automated grading bot using robotic process automation (RPA) software. This grader demonstrates RPA’s capability to enhance the efficiency and accuracy of grading structured query language (SQL) queries. Validation of the RPA grader demonstrates that it can grade assignments and/or exams in 30 to 60 minutes, a task that would take a human grader approximately 50 hours. In contrast to human graders, who misgraded 5 to 8 percent of queries, the RPA grader graded all queries correctly. Notably, it correctly evaluated 188 distinct correct solutions submitted by students to a single question. To facilitate broad adoption, we provide instructions and the necessary code for implementing the RPA grader. We validate that professors and teaching assistants can successfully implement the RPA grader even with no previous bot building experience.
Medical Assistant Health Coaching for Type 2 Diabetes in Primary Care: Results From a Pragmatic Cluster Randomized Controlled Trial
Authors: Fortmann Addie L. , Soriano Emily C. , Gallo Linda C. , Clark Taylor L. , Spierling Bagsic Samantha R. , Sandoval Haley , Jones Jennifer A. , Roesch Scott , Gilmer Todd , Schultz James , Bodenheimer Thomas , Philis-Tsimikas Athena 
Published: May 2024

OBJECTIVE
This cluster (clinic-level) randomized controlled trial (RCT) compared medical assistant (MA) health coaching (MAC) with usual care (UC) among at-risk adults with type 2 diabetes in two diverse real-world primary care environments: a federally qualified health center (FQHC; Neighborhood Healthcare) and a large nonprofit private insurance–based health system (Scripps Health).

RESEARCH DESIGN AND METHODS
A total of 600 adults with type 2 diabetes who met one or more of the following criteria in the last 90 days were enrolled: HbA1c ≥8% and/or LDL cholesterol ≥100 mg/dL and/or systolic blood pressure (SBP) ≥140 mmHg. Participants at MAC clinics received in-person and telephone self-management support from a specially trained MA health coach for 12 months. Electronic medical records were used to examine clinical outcomes in the overall sample. Behavioral and psychosocial outcomes were evaluated in a subsample (n = 300).

RESULTS
All clinical outcomes improved significantly over 1 year in the overall sample (P &lt; 0.001). The reduction in HbA1c was significantly greater in the MAC versus UC group (unstandardized Binteraction = −0.06; P = 0.002). A significant time by group by site interaction also showed that MAC resulted in greater improvements in LDL cholesterol than UC at Neighborhood Healthcare relative to Scripps Health (Binteraction = −1.78 vs. 1.49; P &lt; 0.05). No other statistically significant effects were observed.

CONCLUSIONS
This was the first large-scale pragmatic RCT supporting the real-world effectiveness of MAC for type 2 diabetes in U.S. primary care settings. Findings suggest that this team-based approach may be particularly effective in improving diabetes outcomes in FQHC settings.
peningkatan hasil belajar siswa melalui media Quizizz berpaduan video youtube pada siswa kelas IV sd 1 gamong
Authors: Sari Ratna Eka , Fahrie Nur , Ermawati Diana , Sa'diah Lailatus 
Published: May 2024

Abstract: This research aimed to know improvement of results learning, students learning activity and teacher teaching skill on the topic social culture diversity. This research was conducted in two cycles each cycle consist of 2 meetings steps of planning, acting, observing and reflecting. The research proves that the application quizizz media and youtube video can improve results learning on cognitive aspects with an average grade of 76 – 65 – 7, psychomotor aspect was on increase in the average grade of 64% - 81% and behaviour aspect was on increase in the average grade of 70% - 82%. Inscreasing activity students in the average grade of 70% - 85% and increase of teaher teaching skill of 76% - 86%. It is concluded that application quizizz media and youtube video can improve results learning students, students learning activity and teacher teaching skill on the topic social culture diversity.Keywords: Results learning, Quizizz media, Youtube video.