bluuebunny/crossref_metadata_2025_split huggingface dataset:
Increased expression of the multidrug resistance-associated protein 1 (MRP1) in kidney glomeruli of streptozotocin-induced diabetic rats
Authors: Quezada Claudia , Alarcón Sebastián , Cárcamo Juan G. , Yáñez Alejandro , Casanello Paola , Sobrevia Luis , San Martín Rody 
Published: April 2011

AbstractOxidative stress has been linked to the podocytopathy, mes-angial expansion and progression of diabetic nephropathy. The major cell defence mechanism against oxidative stress is reduced glutathione (GSH). Some ABC transporters have been shown to extrude GSH, oxidised glutathione or their conjugates out of the cell, thus implying a role for these transporters in GSH homeostasis. We found a remarkable expression of mRNA for multidrug resistance-associated proteins (MRP/ABCC) 1, 3, 4 and 5 in rat glomeruli. Three weeks after induction of diabetes in glomeruli of streptozotocin-treated rats, we observed a decline in reduced GSH levels and an increase in the expression and activity of MRP1 (ABCC1). These lower GSH levels were improved byex vivotreatment with pharmacological inhibitors of MRP1 activity (MK571). We conclude that increased activity of MRP1 in diabetic glomeruli is correlated with an inadequate adaptive response to oxidative stress.
Humor with backgrounded incongruity: Does more required suspension of disbelief affect humor perception?
Authors: Samson Andrea C. , Hempelmann Christian F. 
Published: April 2011

AbstractHumorous stimuli, like jokes and cartoons, are assumed to contain a central incongruity in a specific constellation of opposition and overlap that is essential to their humorousness. Many stimuli also contain additional incongruities that the audience usually overlooks, but that may be needed to create the setup for the main incongruity, e.g., animals that talk, space aliens, an Italian, an American, and a Russian sharing a language. Two of the studies described in the present paper investigated the effect of such backgrounded incongruities by removing them from a set of jokes and cartoons and testing how this affects humor processing and appreciation. A third study investigated whether the elimination of a backgrounded incongruity influences the position of a humorous stimulus on the incongruity-resolution and nonsense humor continuum. Methods included computer-based stimulus rating and self-explanations by the participants. The results suggested that backgrounded incongruities influence humor appreciation because their elimination leads to lower funniness and higher aversion. Furthermore, the backgrounded incongruities contribute strongly to the perceived absurdity of a joke. When they are removed, the jokes are perceived less to be nonsense humor but more as incongruity-resolution humor.
Clinically silent somatotroph adenomas are common
Authors: Wade Alisha N , Baccon Jennifer , Grady M Sean , Judy Kevin D , O’Rourke Donald M , Snyder Peter J 
Published: April 2011

ObjectiveSomatotroph adenomas are typically recognized when they secrete GH excessively and cause acromegaly. Both ‘silent’ somatotroph adenomas (immunohistochemical evidence of GH excess without biochemical or clinical evidence) and ‘clinically silent’ somatotroph adenomas (immunohistochemical and biochemical evidence but no clinical evidence) have occasionally been reported. The relative frequency of each presentation is unknown. The goal of this study was, therefore, to determine the frequency of clinically silent somatotroph adenomas, a group that is potentially recognizable in vivo.DesignWe retrospectively identified 100 consecutive patients who had surgically excised and histologically confirmed pituitary adenomas.MethodsEach pituitary adenoma was classified immunohistochemically by pituitary cell type. Somatotroph adenomas were further classified as ‘classic’ (obvious clinical features of acromegaly and elevated serum IGF1), ‘subtle’ (subtle clinical features of acromegaly and elevated IGF1), ‘clinically silent’ (no clinical features of acromegaly but elevated IGF1), and ‘silent’ (no clinical features of acromegaly and normal IGF1).ResultsOf the 100 consecutive pituitary adenomas, 29% were gonadotroph/glycoprotein, 24% somatotroph, 18% null cell, 15% corticotroph, 6% lactotroph, 2% thyrotroph, and 6% not classifiable. Of the 24 patients with somatotroph adenomas, classic accounted for 45.8%, subtle 16.7%, clinically silent 33.3%, and silent 4.2%.ConclusionsClinically silent somatotroph adenomas are more common than previously appreciated, representing one-third of all somatotroph adenomas. IGF1 should be measured in all patients with a sellar mass, because identification of a mass as a somatotroph adenoma expands the therapeutic options and provides a tumor marker to monitor treatment.
Supporting Adolescent Orphan Girls to Stay in School as HIV Risk Prevention: Evidence From a Randomized Controlled Trial in Zimbabwe
Authors: Hallfors Denise , Cho Hyunsan , Rusakaniko Simbarashe , Iritani Bonita , Mapfumo John , Halpern Carolyn 
Published: April 2011

Objectives. Using a randomized controlled trial in rural eastern Zimbabwe, we tested whether comprehensive support to keep orphan adolescent girls in school could reduce HIV risk. Methods. All orphan girls in grade 6 in 25 primary schools were invited to participate in the study in fall 2007 (n = 329). Primary schools were randomized to condition. All primary schools received a universal daily feeding program; intervention participants received fees, uniforms, and a school-based helper to monitor attendance and resolve problems. We conducted annual surveys and collected additional information on school dropout, marriage, and pregnancy rates. We analyzed data using generalized estimating equations over 3 time points, controlling for school and age at baseline. Results. The intervention reduced school dropout by 82% and marriage by 63% after 2 years. Compared with control participants, the intervention group reported greater school bonding, better future expectations, more equitable gender attitudes, and more concerns about the consequences of sex. Conclusions. We found promising evidence that comprehensive school support may reduce HIV risk for orphan girls. Further study, including assessment of dose response, cost benefit, and HIV and herpes simplex virus 2 biomarker measurement, is warranted.
Informal Caregiving and Self-Reported Mental and Physical Health: Results From the Gazel Cohort Study
Authors: Buyck Jean-François , Bonnaud Sophie , Boumendil Ariane , Andrieu Sandrine , Bonenfant Sébastien , Goldberg Marcel , Zins Marie , Ankri Joël 
Published: April 2011

Objectives. We investigated whether, and under what conditions, informal caregiving is associated with improved self-reported physical and mental health, most notably in terms of cognitive functioning. Methods. We performed a cross-sectional analysis of 2008 data from the Gazel Cohort Study, which involved 10 687 men and women aged 54 to 70 years. Multivariate linear and logistic regression models were used to estimate the associations between self-reported health and caregiving status and burden. Results. Regular caregivers with the highest burden scores reported significantly worse health status than did noncaregivers for almost all of the physical and mental outcomes evaluated after adjustment for potential confounding factors. In particular, they reported more cognitive complaints (odds ratio [OR] = 1.44; 95% confidence interval [CI] = 1.21, 1.73). Conversely, caregivers with the lowest burden scores reported better perceived health status, less physical and mental tiredness, and fewer depressive symptoms (OR = 0.50; 95% CI = 0.37, 0.68) than did noncaregivers; however, they did not report decreases in cognitive difficulties (OR = 0.98; 95% CI = 0.81, 1.18). Conclusions. Our findings support the hypothesis that caregiving can have positive effects on health, provided that caregiving activities themselves are not too heavy a burden.
Beyond Faith-Based Organizations: Using Comparative Institutional Ethnography to Understand Religious Responses to HIV and AIDS in Brazil
Authors: Muñoz-Laboy Miguel A. , Murray Laura , Wittlin Natalie , Garcia Jonathan , Terto Jr Veriano , Parker Richard G. 
Published: April 2011

Religious institutions, which contribute to understanding of and mobilization in response to illness, play a major role in structuring social, political, and cultural responses to HIV and AIDS. We used institutional ethnography to explore how religious traditions—Catholic, Evangelical, and Afro-Brazilian—in Brazil have influenced HIV prevention, treatment, and care at the local and national levels over time.We present a typology of Brazil's division of labor and uncover overlapping foci grounded in religious ideology and tradition: care of people living with HIV among Catholics and Afro-Brazilians, abstinence education among Catholics and Evangelicals, prevention within marginalized communities among Evangelicals and Afro-Brazilians, and access to treatment among all traditions.We conclude that institutional ethnography, which allows for multilevel and interlevel analysis, is a useful methodology.
An Overlooked Priority: Puberty in Sub-Saharan Africa
Authors: Sommer Marni 
Published: April 2011

Early adolescence remains an overlooked window of opportunity for public health intervention with girls and boys in sub-Saharan Africa. Minimal health data exist on pubescent girls and boys. Considerable morbidity and mortality related to HIV, sexually transmitted infections, and pregnancy emerge soon after puberty, suggesting the importance of targeting early adolescents. The fundamental goal of primary prevention would be better served if girls and boys between the ages of 10 and 14 years were targeted for effective and contextually relevant interventions. Such interventions should address healthy transitions to young adulthood to effectively advance the public health agenda with postpubescent (aged 15 to 24 years) young women and men. The global health community is overdue to build the empirical database for intervention with this age group.
Comparative Advantage and Skill-Specific Unemployment
Authors: Larch Mario , Lechthaler Wolfgang 
Published: April 2011

Abstract
We introduce unemployment and endogenous selection of workers into different skill-classes in a trade model with two sectors and heterogeneous firms. This allows us to identify three different channels through which trade liberalization can affect unemployment: specialization, changes in productivity, and mobility. These three channels may work in opposite directions and their relative importance depends on the type of trade (intra-industry trade vs. inter-industry trade) and the skill-class of a worker.
We show that the gains from trade are distributed very unequally. When a skilled worker abundant country opens up to trade with a country that is unskilled worker abundant, the biggest losers are the skilled workers in the import sector in the skill abundant country. However, average unemployment among skilled workers goes down, while average unemployment among unskilled workers goes up.
Atorvastatin and Low-Density Lipoprotein Cholesterol in Type 2 Diabetes Mellitus Patients on Hemodialysis
Authors: März Winfried , Genser Bernd , Drechsler Christiane , Krane Vera , Grammer Tanja B. , Ritz Eberhard , Stojakovic Tatjana , Scharnagl Hubert , Winkler Karl , Holme Ingar , Holdaas Hallvard , Wanner Christoph 
Published: April 2011

Summary

Background and objectives
Patients undergoing maintenance hemodialysis are at high cardiovascular risk. Lowering LDL-cholesterol with statins reduces the incidence rate of cardiovascular events in patients with chronic kidney disease. In contrast, two randomized, prospective, placebo-controlled trials have been completed in hemodialysis patients that showed no significant effects of statins on cardiovascular outcomes.

Design, setting, participants, & measurements
A post hoc analysis was conducted of the 4D (Die Deutsche Diabetes Dialyze) study to investigate whether LDL-cholesterol at baseline is predictive of cardiovascular events and whether the effect of atorvastatin on clinical outcomes depends on LDL-cholesterol at baseline.

Results
High concentrations of LDL-cholesterol by tendency increased the risks of cardiac endpoints and all-cause mortality. Concordantly, atorvastatin significantly reduced the rates of adverse outcomes in the highest quartile of LDL-cholesterol (≥145 mg/dl, 3.76 mmol/L). The hazard ratios and 95% confidence intervals were 0.69 (0.48 to 1.00) for the composite primary endpoint, 0.58 (0.34 to 0.99) for cardiac death, 0.48 (0.25 to 0.94) for sudden cardiac death, 0.62 (0.33 to 1.17) for nonfatal myocardial infarction, 0.68 (0.47 to 0.98) for all cardiac events combined, and 0.72 (0.52 to 0.99) for death from all causes, respectively. No such decrease was seen in any of the other quartiles of LDL-cholesterol at baseline.

Conclusions
In patients with type 2 diabetes mellitus undergoing hemodialysis, atorvastatin significantly reduces the risk of fatal and nonfatal cardiac events and death from any cause if pretreatment LDL-cholesterol is >145 mg/dl (3.76 mmol/L).
Recurrence of Secondary Glomerular Disease after Renal Transplantation
Authors: Ponticelli Claudio , Moroni Gabriella , Glassock Richard J. 
Published: April 2011

Summary
The risk of a posttransplant recurrence of secondary glomerulonephritis (GN) is quite variable. Histologic recurrence is frequent in lupus nephritis, but the lesions are rarely severe and usually do not impair the long-term graft outcome. Patients with Henoch-Schonlein nephritis have graft survival similar to that of other renal diseases, although recurrent Henoch-Schonlein nephritis with extensive crescents has a poor prognosis. Amyloid light-chain amyloidosis recurs frequently in renal allografts but it rarely causes graft failure. Amyloidosis secondary to chronic inflammation may also recur, but this is extremely rare in patients with Behcet's disease or in those with familial Mediterranean fever, when the latter are treated with colchicine. Double organ transplantation (liver/kidney; heart/kidney), chemotherapy, and autologous stem cell transplantation may be considered in particular cases of amyloidosis, such as hereditary amyloidosis or multiple myeloma. There is little experience with renal transplantation in light-chain deposition disease, fibrillary/immunotactoid GN, or mixed cryoglobulinemic nephritis but successful cases have been reported. Diabetic nephropathy often recurs but usually only after many years. Recurrence in patients with small vessel vasculitis is unpredictable but can cause graft failure. However, in spite of recurrence, patient and graft survival rates are similar in patients with small vessel vasculitis compared with those with other renal diseases. Many secondary forms of GN no longer represent a potential contraindication to renal transplantation. The main issues in transplantation of patients with secondary GN are the infectious, cardiovascular, or hepatic complications associated with the original disease or its treatment.
Icodextrin Increases Technique Survival Rate in Peritoneal Dialysis Patients with Diabetic Nephropathy by Improving Body Fluid Management
Authors: Takatori Yuji , Akagi Shigeru , Sugiyama Hitoshi , Inoue Junko , Kojo Shoichiro , Morinaga Hiroshi , Nakao Kazushi , Wada Jun , Makino Hirofumi 
Published: April 2011

Summary

Background and objectives
There are still controversies whether peritoneal dialysis (PD) with icodextrin preserves residual renal and peritoneal membrane functions in patients with diabetes. However, there are no randomized controlled and long-term clinical trials in newly started PD patients with diabetic nephropathy.

Design, setting, participants, & measurements
Forty-one patients with diabetic nephropathy with ESRD were enrolled and randomly assigned to the glucose group (GLU) treated with 8 L of 1.5% or 2.5% glucose or an icodextrin group (ICO) treated with 1.5 or 2.0 L of 7.5% icodextrin-containing solutions. Technique failure, body fluid management, glucose and lipid metabolism, and residual renal and peritoneal functions and were evaluated over 2 years.

Results
The technique survival rate was 71.4% in ICO and 45.0% in GLU, with most of the technique failure due to volume overload. ICO showed significantly better cumulative technique survival. Net ultrafiltration volume was significantly higher in ICO throughout the study period. There were no beneficial effects of icodextrin on hemoglobin A1c, glycoalbumin, and lipid profile at 24 months. Urine volume and residual renal function declined faster in ICO, but there were no significant differences between the two groups. For peritoneal function, no differences were observed in dialysis-to-plasma creatinine ratios during the observation.

Conclusions
In PD therapy for diabetic nephropathy, the use of icodextrin-containing solutions has a beneficial effect on technique survival, but there are no apparent benefits or disadvantages in residual renal and peritoneal functions compared with conventional PD with glucose solution.
Epistemic arguments against dictatorship
Authors: Litwack Eric 
Published: April 2011

Abstract
In this article I examine what I term epistemic arguments against epistocratic dictatorships against the background of Harry Frankfurt’s claim that truth is a fundamental governing notion, and some key reflections of Václav Havel and Leszek Kolakowski. Some of the key epistemic arguments offered by Karl Popper, Robert A. Dahl and Ross Harrison are outlined and endorsed. They underscore the insurmountable problems involved in choosing and maintaining a state of allegedly perfectly wise and efficient rulers. Such rule by virtue of supposed supreme knowledge and expertise denies a truthful recognition of the inevitable fallibility of the state, and of government policies. Moreover, the repression of both citizens’ commitment to truthfulness and their attempts at political falsification will necessarily render dictatorships both continually prone to error and inevitably oppressive. Fallibilistic epistemology is thus seen as a formidable philosophical arsenal for anti-totalitarian and democratic thought, alongside ethical and historical arguments against dictatorship.
Medical school and residency influence on choice of an academic career and academic productivity among neurosurgery faculty in the United States
Authors: Campbell Peter G. , Awe Olatilewa O. , Maltenfort Mitchell G. , Moshfeghi Darius M. , Leng Theodore , Moshfeghi Andrew A. , Ratliff John K. 
Published: April 2011

Object
Factors determining choice of an academic career in neurological surgery are unclear. This study seeks to evaluate the graduates of medical schools and US residency programs to determine those programs that produce a high number of graduates remaining within academic programs and the contribution of these graduates to academic neurosurgery as determined by h-index valuation.

Methods
Biographical information from current faculty members of all accredited neurosurgery training programs in the US with departmental websites was obtained. Any individual who did not have an American Board of Neurological Surgery certificate (or was not board eligible) was excluded. The variables collected included medical school attended, residency program completed, and current academic rank. For each faculty member, Web of Science and Scopus h-indices were also collected.

Results
Ninety-seven academic neurosurgery departments with 986 faculty members were analyzed. All data regarding training program and medical school education were compiled and analyzed by center from which each faculty member graduated. The 20 medical schools and neurosurgical residency training programs producing the greatest number of graduates remaining in academic practice, and the respective individuals' h-indices, are reported. Medical school graduates of the Columbia University College of Physicians and Surgeons chose to enter academics the most frequently. The neurosurgery training program at the University of Pittsburgh produced the highest number of academic neurosurgeons in this sample.

Conclusions
The use of quantitative measures to evaluate the academic productivity of medical school and residency graduates may provide objective measurements by which the subjective influence of training experiences on choice of an academic career may be inferred. The top 3 residency training programs were responsible for 10% of all academic neurosurgeons. The influence of medical school and residency experiences on choice of an academic career may be significant.
Effect of liquid embolic agents on Gamma Knife surgery dosimetry for arteriovenous malformations
Authors: Mamalui-Hunter Maria , Jiang Thomas , Rich Keith M. , Derdeyn Colin P. , Drzymala Robert E. 
Published: April 2011

Object
The effectiveness of Gamma Knife stereotactic surgery to obliterate brain arteriovenous malformations (AVMs) may be diminished by the preoperative adjunctive use of endovascular liquid embolic agents. The purpose of the present investigation was to determine if commercially available liquid embolic agents reduce the radiation dose to the target because of attenuation of the 60Co beam.

Methods
The apparent linear attenuation coefficients for 120- to 140-keV radiographs in embolized regions were retrieved from CT scans for several patients with AVMs who had undergone embolization procedures with liquid embolic agents to reduce nidal volumes. Based on these coefficients and a virtual model of Gamma Knife surgery (GKS) with basic ray tracing, the authors obtained the path lengths and densities of the embolized regions. The attenuation of 60Co beams was then calculated for various sizes and positions of embolized AVM regions and for the number of beams used for treatment. Published experiments for several high-atomic-number materials were used to estimate the effective 60Co beam attenuation coefficients for the N-butyl cyanoacrylate (NBCA, suspended in ethiodized oil) and ethylene vinyl alcohol copolymer (EVOH, with suspended micronized tantalum powder, Onyx) used in the AVM embolizations. Dose reductions during GKS were calculated for a theoretical model based on the CT-documented apparent linear attenuation coefficients and for the 60Co energy attenuation coefficient. Dose measurements were obtained in a phantom study with EVOH for comparison with the estimates generated from the two attenuation coefficients.

Results
Based on CT (keV) apparent attenuation coefficients, the authors' theoretical model predicted that the cumulative effect of either of the embolic agents decreased the number of kilovoltage photons in an embolized nidus by −8% to −15% because of the increased atomic number and density of NBCA and Onyx. However, in using the effective attenuation coefficient for the 60Co energies as is used in GKS, the authors' theoretical model yielded only a 0.2% dose reduction per beam and a < 0.01%–0.2% dose reduction in total. These theoretical results were validated by measurements in a head phantom containing Onyx.

Conclusions
Dose reduction due to attenuation of the 60Co beam by the AVM embolization material was negligible for both NBCA and EVOH because of the high-energy 60Co beam.