bluuebunny/crossref_metadata_2025_split huggingface dataset:
Neonatal jaundice is associated with increased risks of congenital anomalies of the kidney and urinary tract and concomitant urinary tract infection
Authors: Chou Hsin-Hsu , Huang Lin-Chih , Shen Shang-Po , Tsai Ming-Luen , Chang Yu-Chia , Lin Hung-Chi 
Published: April 2024

AbstractThe link between neonatal jaundice and urinary tract infection (UTI) remains debated, with congenital kidney and urinary tract anomalies (CAKUT) potentially playing a role. This population-based study aimed to analyze the correlations between neonatal jaundice, CAKUT, and concomitant UTI. The study cohort consisted of 2,078,122 live births from 2004 to 2014. We linked several population-based datasets in Taiwan to identify infants with unexplained neonatal jaundice and their mothers. The primary outcome was the rate of CAKUT occurring within 3 years after delivery, and the presence of concomitant UTI during neonatal jaundice hospitalization. Infants with neonatal jaundice had a significantly higher risk of CAKUT (adjusted odds ratio [aOR] 1.24, 95% confidence interval [CI] 1.11–1.39) during early childhood. Among the subtypes of CAKUT, obstructive uropathy, vesicoureteral reflux and other CAKUT were associated with an increased risk of neonatal jaundice. Infants who underwent intensive phototherapy, had a late diagnosis (> 14 days of postnatal age) or underwent a prolonged duration of phototherapy (> 3 days) exhibited a higher risk of concomitant UTI compared to other infants with jaundice. Our findings indicate a notable association between neonatal jaundice and increased risks of UTIs in the context of CAKUT. This study underscore the importance of vigilant monitoring and timely interventions for neonates presenting with jaundice, while acknowledging the complexity and variability in the progression of CAKUT and its potential connection to UTIs.
A Microfluidic and Numerical Analysis of Non-equilibrium Phase Behavior of Gas Condensates
Authors: Dorhjie Desmond Batsa , Pereponov Dmitrii , Aminev Timur , Gimazov Azat , Khamidullin Denis , Kuporosov Dmitry , Tarkhov Michael , Rykov Alexander , Filippov Ivan , Mukhina Elena , Shilov Evgeny , Grishin Pavel , Cheremisin Alexey 
Published: April 2024

AbstractConventional assumptions about multiphase flow in gas condensate reservoirs often do not correlate with field production. This discrepancy stems from the various mechanisms influencing the multiphase process, which are inadequately represented in numerical models. One of the least understood mechanisms is the influence of the non-equilibrium thermodynamics on the flow in the wellbore region, where the reservoir pressure is below the dew point pressure. To address this problem, experimental and mathematical analyses were conducted using a microfluidic device designed to replicate the flow dynamics in a gas condensate system. The experimental results showed an 11% deviation from the initial pressure of condensate saturation when compared with the conventional assumption of local equilibrium in numerical models. Similarly, there is a 14% deviation between the experimental and simulated volumes of the condensate. These findings underscore the inadequacy of existing models to accurately predict the saturation profile of the condensate phase. A mathematical model based on a relaxation parameter was applied to account for non-equilibrium phase separation and the fog state of the aerosol as observed in the microfluidic experiment. Incorporating a relaxation parameter ($$\tau$$
τ
) enhanced the accuracy of the prediction of the initial pressure of the condensate saturation and an improvement in the prediction of the condensate volumes from 76% to 97.2%. Consequently, it provides a valuable framework and insight on the non-equilibrium phase behavior of gas condensate systems under constant flow regimes.
The relationship between complement C1q and coronary plaque vulnerability based on optical coherence tomography analysis
Authors: Wang Yuan , Zheng Jiawei , Li Qing , Ma Yao , Liu Chang , Deng Jie , Gao Dengfeng 
Published: April 2024

AbstractTo determine the association between complement C1q and vulnerable plaque morphology among coronary artery disease (CAD) patients. We conducted a retrospective observational study of 221 CAD patients admitted to The Second Affiliated Hospital of Xi’an Jiaotong University. Intravascular optical coherence tomography was utilized to describe the culprit plaques’ morphology. Using logistic regression analysis to explore the correlation between C1q and vulnerable plaques, and receiver operator characteristic (ROC) analysis assess the predictive accuracy. As reported, the complement C1q level was lower in ACS patients than CCS patients (18.25 ± 3.88 vs. 19.18 ± 4.25, P = 0.045). The low complement-C1q-level group was more prone to develop vulnerable plaques. In lipid-rich plaques, the complement C1q level was positively correlated with the thickness of fibrous cap (r = 0.480, P = 0.041). Univariate and multivariate logistic regression analyses suggested that complement C1q could be an independent contributor to plaques’ vulnerability. For plaque rupture, erosion, thrombus, and cholesterol crystals, the areas under the ROC curve of complement C1q level were 0.873, 0.816, 0.785, and 0.837, respectively (P < 0.05 for all). In CAD patients, the complement C1q could be a valuable indicator of plaque vulnerability.
Biological characteristics of molecular subtypes of ulcerative colitis characterized by ferroptosis and neutrophil infiltration
Authors: Sun Shaopeng , Mao Yuqing , Le Sihua , Zheng Mingxu , Li Menglin , Chen Yifei , Chen Jiajia , Fan Yihong , Lv Bin 
Published: April 2024

AbstractClinical ulcerative colitis (UC) is a heterogeneous condition. Moreover, medical interventions are nonspecific, and thus, treatment responses are inconsistent. The aim of this study was to explore the molecular subtypes and biological characteristics of UC based on ferroptosis and neutrophil gene sets. Multiple intestinal mucosa gene expression profiles of UC patients in the Gene Expression Omnibus (GEO) database were downloaded. Unsupervised clustering methods were used to identify potential molecular subtypes based on ferroptosis and neutrophil gene sets. Multiple immune infiltration algorithms were used to evaluate the biological characteristics of the molecular subtypes. Machine learning identifies hub genes for molecular subtypes and analyses their diagnostic efficacy for UC and predictive performance for drug therapy. The relevant conclusions were verified by clinical samples and animal experiments. Four molecular subtypes were identified according to the ferroptosis and neutrophil gene sets: neutrophil, ferroptosis, mixed and quiescent. The subtypes have different biological characteristics and immune infiltration levels. Multiple machine learning methods jointly identified four hub genes (FTH1, AQP9, STEAP3 and STEAP4). Receiver operating characteristic (ROC) curve analysis revealed that the four hub genes could be used as diagnostic markers for UC. The clinical response profile data of infliximab treatment patients showed that AQP9 and STEPA4 were reliable predictors of infliximab treatment response. In human samples the AQP9 and STEAP4 protein were shown to be increased in UC intestinal samples. In animal experiments, the ferroptosis and neutrophil phenotype were confirmed. Dual analysis of ferroptosis and neutrophil gene expression revealed four subgroups of UC patients. The molecular subtype-associated hub genes can be used as diagnostic markers for UC and predict infliximab treatment response.
Liproxstatin-1 attenuates acute hypertriglyceridemic pancreatitis through inhibiting ferroptosis in rats
Authors: Xiang Xuelian , Xu Mengtao , Liu Li , Meng Nuo , Lei Yu , Feng Yong , Tang Guodu 
Published: April 2024

AbstractFerroptosis is closely associated with inflammatory diseases, including acute pancreatitis (AP); however, the involvement of ferroptosis in hypertriglyceridemic pancreatitis (HTGP) remains unclear. In the present study, we aimed to explore the relationship between lipid metabolism and ferroptosis in HTGP and the alleviating effect of liproxstatin-1 (Lip-1) in vivo. This study represents the first exploration of lipid metabolism and endoplasmic reticulum stress (ERS) in HTGP, targeting ferroptosis as a key factor in HTGP. Hypertriglyceridemia (HTG) was induced under high-fat diet conditions. Cerulein was then injected to establish AP and HTGP models. Lip-1, a specific ferroptosis inhibitor, was administered before the induction of AP and HTGP in rats, respectively. Serum triglyceride, amylase, inflammatory factors, pathological and ultrastructural structures, lipid peroxidation, and iron overload indicators related to ferroptosis were tested. Moreover, the interaction between ferroptosis and ERS was assessed. We found HTG can exacerbate the development of AP, with an increased inflammatory response and intensified ferroptosis process. Lip-1 treatment can attenuate pancreatic injury by inhibiting ferroptosis through lipid metabolism and further resisting activations of ERS-related proteins. Totally, our results proved lipid metabolism can promote ferroptosis in HTGP by regulating ACSL4/LPCAT3 protein levels. Additionally, ERS may participate in ferroptosis via the Bip/p-EIF2α/CHOP pathway, followed by the alleviating effect of Lip-1 in the rat model.
Load carriage changes tibiofemoral arthrokinematics during ambulatory tasks in recruit-aged women
Authors: Johnson Camille C. , Dzewaltowski Alex C. , Dever Dennis E. , Krajewski Kellen T. , Rai Ajinkya , Ahamed Nizam U. , Allison Katelyn F. , Flanagan Shawn D. , Graham Scott M. , Lovalekar Mita , Anderst William J. , Connaboy Chris 
Published: April 2024

AbstractThe introduction of women into U.S. military ground close combat roles requires research into sex-specific effects of military training and operational activities. Knee osteoarthritis is prevalent among military service members; its progression has been linked to occupational tasks such as load carriage. Analyzing tibiofemoral arthrokinematics during load carriage is important to understand potentially injurious motion and osteoarthritis progression. The study purpose was to identify effects of load carriage on knee arthrokinematics during walking and running in recruit-aged women. Twelve healthy recruit-aged women walked and ran while unloaded (bodyweight [BW]) and carrying additional + 25%BW and + 45%BW. Using dynamic biplane radiography and subject-specific bone models, tibiofemoral arthrokinematics, subchondral joint space and center of closest contact location between subchondral bone surfaces were analyzed over 0–30% stance (separate one-way repeated measures analysis of variance, load by locomotion). While walking, medial compartment contact location was 5% (~ 1.6 mm) more medial for BW than + 45%BW at foot strike (p = 0.03). While running, medial compartment contact location was 4% (~ 1.3 mm) more lateral during BW than + 25%BW at 30% stance (p = 0.04). Internal rotation was greater at + 45%BW compared to + 25%BW (p < 0.01) at 30% stance. Carried load affects tibiofemoral arthrokinematics in recruit-aged women. Prolonged load carriage could increase the risk of degenerative joint injury in physically active women.
Ecological inferences on invasive carp survival using hydrodynamics and egg drift models
Authors: Xu Ruichen , Chapman Duane C. , Elliott Caroline M. , Call Bruce C. , Jacobson Robert B. , Wang Binbin 
Published: April 2024

AbstractBighead carp (Hypophthalmichthys nobilis), silver carp (H. molitrix), black carp (Mylopharyngodon piceus), and grass carp (Ctenopharyngodon idella), are invasive species in North America. However, they hold significant economic importance as food sources in China. The drifting stage of carp eggs has received great attention because egg survival rate is strongly affected by river hydrodynamics. In this study, we explored egg-drift dynamics using computational fluid dynamics (CFD) models to infer potential egg settling zones based on mechanistic criteria from simulated turbulence in the Lower Missouri River. Using an 8-km reach, we simulated flow characteristics with four different discharges, representing 45–3% daily flow exceedance. The CFD results elucidate the highly heterogeneous spatial distribution of flow velocity, flow depth, turbulence kinetic energy (TKE), and the dissipation rate of TKE. The river hydrodynamics were used to determine potential egg settling zones using criteria based on shear velocity, vertical turbulence intensity, and Rouse number. Importantly, we examined the difference between hydrodynamic-inferred settling zones and settling zones predicted using an egg-drift transport model. The results indicate that hydrodynamic inference is useful in determining the ‘potential’ of egg settling, however, egg drifting paths should be taken into account to improve prediction. Our simulation results also indicate that the river turbulence does not surpass the laboratory-identified threshold to pose a threat to carp eggs.
Association between Baltic sea diet and healthy Nordic diet index with risk of non-alcoholic fatty liver disease: a case–control study
Authors: Rasoulizadeh Zahra , Namazi Abolfazl , Sohouli Mohammad Hassan , Rohani Pejman , Hekmatdoost Azita , Hosseinzadeh Mahdieh 
Published: April 2024

AbstractRecent evidence shows the beneficial effects of Baltic Sea diet score (BSDS) and healthy Nordic diet index (HNDI) on chronic diseases, however, there is no evidence to investigate them on the risk of non-alcoholic fatty liver disease (NAFLD). The purpose of this study was to investigate the associations between BSDS and HNDI with the risk of NAFLD. In this case–control study, 552 people in good health and 340 people with NAFLD over the age of 18 took part. The evaluation of BSDS and HNDI employed a validated 168-item semi-quantitative food frequency questionnaire (FFQ). Binary logistic regression was used to determine how OBS and NAFLD are related. The mean BSDS and HNDI were 16.00 ± 2.49 and 11.99 ± 2.61, respectively. The final model's confounder adjustment revealed that greater HNDI adherence scores gave protection against the occurrence of NAFLD (odds ratio [OR]: 0.42; 95% confidence interval [CI] 0.18–0.98; P for trend = 0.043). In addition, those with the highest BSDS scores had significantly lower risks of developing NAFLD compared to subjects with the lowest scores (OR = 0.48, 95% CI 0.32–0.89; p for trend = 0.003). Our findings showed that following a healthy Nordic diet can significantly prevent the risk of developing NAFLD, and suggest that the highly nutritious components of the Nordic diet are beneficial for the prevention of NAFLD.
FDG-PET in HIV-Positive Patient with Extranodal Diffuse Large B-Cell Lymphoma
Authors: Mashriqi Faizullah , Keir Graham , Vijayashankar Akarsh , Glaser Joseph E. , Franceschi Ana M. 
Published: April 2024

AbstractExtranodal diffuse large B-cell lymphoma (DLBCL) is a heterogeneous disease process and an aggressive form of non-Hodgkin's lymphoma. We present a case of multiorgan involvement of DLBCL in a patient with documented risk factors, including [18F] fluorodeoxyglucose positron emission tomography/magnetic resonance imaging findings highlighting striking perineural spread involving intracranial and extracranial segments of the bilateral trigeminal nerves.
Dynamics of seaweed-inspired piezoelectric plates for energy harvesting from oscillatory cross flow
Authors: Zhu Qiang , Xiao Qing 
Published: April 2024

Abstract
Inspired by the vibrations of aquatic plants such as seaweed in the unsteady flow fields generated by free-surface waves, we investigate a novel device based on piezoelectric plates to harvest energy from oscillatory cross flows. Towards this end, numerical studies are conducted using a flow-structure-electric interaction model to understand the underlying physical mechanisms involved in the dynamics and energy harvesting performance of one or a pair of piezoelectric plates in an oscillatory cross flow. In a single-plate configuration, both periodic and irregular responses have been observed depending on parameters such as normalized plate stiffness and Keulegan–Carpenter number. Large power harvesting is achieved with the excitation of natural modes. Besides, when the time scale of the motion and the intrinsic time scale of the circuit are close to each other the power extraction is enhanced. In a two-plate configuration with tandem formation, the hydrodynamic interaction between the two plates can induce irregularity in the response. In terms of energy harvesting, two counteracting mechanisms have been identified, shielding and energy recovery. The shielding effect reduces plate motion and energy harvesting, whereas with the energy recovery effect one plate is able to recovery energy from the wake of another for performance enhancement. The competition between these mechanisms leads to constructive or destructive interactions between the two plates. These results suggest that for better performance the system should be excited at its natural period, which should be close to the intrinsic time scale of the circuit. Moreover, using a pair of plates in a tandem formation can further improve the energy harvesting capacity when conditions for constructive interaction are satisfied.
Random maps with sociological flavor
Authors: Krapivsky P L 
Published: April 2024

Abstract
A map of a set to itself admits a representation by a graph with vertices being the elements of the set and an edge between every vertex and its image. Communities defined as the maximal connected components are uni-cyclic. The distributions of the sizes of communities and lengths of cycles for unconstrained random maps is a classical subject. We call experts the images and followers the remaining vertices, and we further define prophets, egocentrics, and introverts. We introduce and analyze classes of random maps with sociological flavor.
Applicability of a new composite amusement ride safety device based on acoustic emission monitoring technology
Authors: Liu Ran , Liang Yu-Jiao , Liu Shuo , Zhang Peng-Fei , Qiao Shuai , Li Qing , Ma Lian-Hua , Zhou Wei 
Published: April 2024

Abstract
Under the premise of ensuring safety, it is of great significance to realize the lightweight of the non-main load-bearing parts of amusement facilities. The purpose of this study is to study the failure process of a newly designed carbon fiber bumper by using acoustic emission technology. First of all, the design of carbon fiber anti-collision bar can effectively restrain passengers, and its weight is reduced by nearly two-thirds compared to traditional metal materials. Subsequently, the load-bearing capacity of the bumper was tested and acoustic emission monitoring was carried out. The test results show that this new type of combined structure of amusement facility has high reliability, which exceeds the safety factor of 3.5 required by the steel structure of amusement facility. In addition, Renyi entropy was used to select the best window function of short-time Fourier transform, and the frequency domain characteristics of acoustic emission signals of typical damage modes were discussed through appropriately selected windows function. A classifier based on supervised machine learning is established by combining frequency features and acoustic emission feature parameters. Furthermore, the use of classifiers helps to understand the damage behaviour of composite structures.
The pharmacist’s role in optimizing medication management before, during, and after minimally invasive and bariatric surgery
Authors: Ebbitt Laura M , Kassel Lynn E , McKenzie Jeffrey J , Palm Nicole M , Smith April N 
Published: April 2024

Abstract

Purpose
Minimally invasive surgery (MIS) with integrated enhanced recovery pathways (ERPs) helps reduce length of stay and improve surgical outcomes. As these procedures have become more prevalent over time, pharmacists are in key positions to manage medications in the perioperative space to help optimize transitions of care and reduce safety events. Here we identify several clinical areas across phases of care for these procedures in which the knowledge and guidance of pharmacists, as members of the interprofessional team, are paramount.

Summary
Perioperative pharmacy expertise is often required for MIS procedures in the areas of acid suppression, antithrombotic management, blood glucose control, drug formulation, immunosuppressant optimization, pain mitigation, and postoperative nausea and vomiting prevention and treatment. For each MIS procedure, pharmacists should identify and consider diet and anatomical changes as well as patient- and surgery-specific risk factors. Pharmacists can then utilize their knowledge of the pharmacokinetics and pharmacodynamics of individual medications along with evidence-based medicine to recommend selection of appropriate agents.

Conclusion
Pharmacist contributions to perioperative medication management for MIS procedures can improve care as surgical patients navigate transitions through the perioperative setting. Pharmacists can further incorporate medication expertise through development and implementation of institutional MIS protocols within the context of ERPs. As such, any pharmacist should feel empowered to aid in the care of surgical patients.
Against God of the truth-value gaps
Authors: Parent T 
Published: April 2024

Abstract
Beall and Cotnoir propose that ‘God can create an unliftable stone’ is a truth-value gap (neither true nor false). However, this yields a revenge paradox on whether God can eschew gaps. Can God avoid gappy ascriptions of power? Either way, God’s power seems to have limits. In response, it may be said that ascribing God the power to avoid gaps is itself gappy – it concerns a power that God neither has nor lacks. Yet this ends up being inconsistent, for it implies that God definitely lacks that power. Following Aquinas, perhaps Beall and Cotnoir could accept this lack and still uphold omnipotence, suggesting that the power to avoid gaps is impossible for God. Yet the Aquinian stratagem is enough to block the original paradox, which saps the motivation to proffer truth-value gaps in addition. I conclude that the gappy solution is either inadequate or insufficiently motivated.