bluuebunny/crossref_metadata_2025_split huggingface dataset:
Epidemiology of physical activity and sedentary behavior levels among patients entering treatment for substance use disorder in the United States: a descriptive study
Authors: Churchill Sydney L. , Lansing Jeni E. , Brellenthin Angelique G. , Meyer Jacob D. 
Published: April 2024

IntroductionLittle is known about physical activity behaviors among people with SUD. This study aimed to (a) describe self-reported moderate-to-vigorous physical activity (MVPA) and sedentary (SED) behaviors of adults with SUD initiating treatment (b), determine the potential contributions of drug of choice (DOC) on these behaviors, and (c) determine the potential contributions of level of care and demographic variables on these behaviors.MethodsSecondary data that was collected via surveys including demographic information, psychological health, drug of choice, MVPA (categorized as inactive, insufficiently active, meets guidelines, exceeds guidelines) and SED (&lt;4 h/day, 4-&lt;6 h/day, 6-8 h/day, &gt;8 h/day) were analyzed from 1,293 patients in inpatient/outpatient treatment facilities across the United States. ResultsOn average, over half (51%) of patients entering treatment reported not meeting guidelines, but sitting time was generally low (median= 360 min/day). MVPA levels differed based on level of care (p&lt;0.001) with 48% of patients in detox facilities reporting inactivity compared to 37% in residential and 29% in outpatient programs. MVPA and SED levels differed by sex with women less likely to report sitting &lt;4 h/day (27.9% vs. 38.2%, p&lt;0.001) and more likely to report sitting for &gt;8 h/day (31.5% vs. 21.8%, p&lt;0.001) compared to men. SED differed by race (p=0.01), with 54% of Black patients reporting &lt;4 h/day compared to 33% of White patients. DiscussionUnderstanding activity behavior patterns among individuals entering SUD treatment provides opportunities for identifying the extent of lifestyle behavior needs and opportunities to develop personalized treatment strategies.
Increased brain gyrification and cortical thinning in winter-born patients with schizophrenia spectrum
Authors: Torigoe Misako , Takahashi Tsutomu , Takayanagi Yoichiro , Sasabayahi Daiki , Kobayashi Haruko , Sakamoto Kazumi , Yuasa Yusuke , Tsujii Noa , Noguchi Kyo , Suzuki Michio 
Published: April 2024

IntroductionThe findings of epidemiological studies suggest that a relationship exists between the risk of schizophrenia and winter births in the Northern Hemisphere, which may affect the process of fetal neurodevelopment. However, it remains unclear whether birth seasons are associated with the brain morphological characteristics of patients within the schizophrenia spectrum.MethodsThe present magnetic resonance imaging study using FreeSurfer software examined the effects of birth seasons (i.e., summer-born vs. winter-born) on the comprehensive brain surface characteristics of 101 patients with schizophrenia (48 summer- and 53 winter-born), 46 with schizotypal disorder (20 summer- and 26 winter-born), and 76 healthy control subjects (28 summer- and 48 winter-born).ResultsIn comparisons with summer-born patients, winter-born patients, particularly those with schizophrenia, showed significantly increased gyrification mainly in the left lateral occipital and inferior temporal regions and right fronto-parietal region as well as cortical thinning in the right superior frontal region. Birth seasons did not significantly affect the local gyrification index or cortical thickness in healthy controls.DiscussionThe present whole-brain surface-based analysis demonstrated that brain morphological characteristics reported in the schizophrenia spectrum were more pronounced in winter-born patients than in summer-born patients, suggesting the contribution of early neurodevelopmental factors associated with birth seasons to the pathophysiology of the schizophrenia spectrum.
Clinical trial capacity building in a pandemic—outcome of a rapid site readiness project in Latin America
Authors: Clemens Sue Ann Costa , Gonzalez Isabela , Sereni Daniele , Clemens Ralf 
Published: April 2024

BackgroundLatin America (Latam) has a tradition of large-scale vaccine trials. Because of fluctuating demand, many sites have downsized their infrastructure. Therefore, BMGF launched a clinical trial site-readiness initiative early in the coronavirus-2019 (COVID-19) pandemic including Latam countries between August and September 2020. This survey evaluated clinical development performance measures pre/post initiative (September 2022).Results20/21 prequalified sites participated in COVID-19 vaccine/drug development trials. 156 clinical trials (140 COVID-19 vaccine/drug trials) were initiated in the 2 years since prequalification, compared to 176 in the 5 years before. 33,428/37,810 participants were included in COVID-19 programs. The number of enrolled subjects/day across sites quadrupled from 15 (1–35) to 63 (5–300). The dropout rate was 6.8%. Study approval timelines were reduced from 60 (12–120) to 35 (5–90) days. Mean qualified staff was increased from 24 (6–80) to 88 (22–180).ConclusionClinical trial sites across Latam were successfully prequalified to participate in COVID-19 developments. For the 100 days mission of vaccine availability in a new pandemic sufficient and well-trained clinical trial sites readily available are essential. This is only achievable if sites—especially in low/middle-income countries—are maintained active through a constant flow of vaccine studies.
Influences of superfine-grinding and mix enzymatic hydrolysis combined with hydroxypropylation or acetylation on the structure and physicochemical properties of jujube kernel fiber
Authors: Zhang Jiangning , Ye Zheng 
Published: April 2024

IntroductionJujube kernel is a low-cost and abundant fiber resource, but its application in food industry is little because of its lower soluble fiber content and poor physicochemical properties.MethodsIn the current study, jujube kernel fiber (JKF) was modified by three composite methods: superfine-grinding and mix enzymatic hydrolysis alone, and combined with acetylation or hydroxypropylation.Results and discussionAfter these modifications, the microstructure of JKF became more porous, and its soluble fiber and extractable polyphenol contents, surface area, water adsorption and expansion capacities, and cation exchange capacity were all significantly improved (p &lt; 0.05). Moreover, superfine-grinding and mix enzymatic hydrolysis combined with acetylation treated JKF showed the highest surface hydrophobicity (43.57) and adsorption ability to oil (4.47 g∙g−1). Superfine-grinding, mix enzymatic hydrolysis and hydroxypropylation treated JKF exhibited the largest surface area (142.53 m2∙kg−1), the highest soluble fiber content (17.43 g∙100 g−1), viscosity (14.54 cP), adsorption capacity to glucose (29.61 μmol∙g−1), cation exchange capacity (40.82), and water expansion ability (7.60 mL∙g−1). Therefore, superfine-grinding and mix enzymatic hydrolysis combined with hydroxypropylation or acetylation were both good choice to improve the physicochemical properties of JKF.
The use of a minimally invasive integrated endoscopic system to perform hemilaminectomies in chondrodystrophic dogs with thoracolumbar intervertebral disc extrusions
Authors: MacQuiddy Brittany , Bartner Lisa , Marolf Angela , Rao Sangeeta , Dupont Emily , Adams Taylor , Monnet Eric 
Published: April 2024

IntroductionThe objective was to evaluate the use of a minimally invasive surgical (MIS) approach to perform hemilaminectomies in chondrodystrophic dogs with thoracolumbar intervertebral disc extrusions (IVDE). Additionally, we aimed to evaluate the degree of soft tissue trauma using the endoscopic procedure compared to the standard open approach.MethodsEight client-owned dogs presented to the Colorado State University Veterinary Teaching Hospital with acute onset thoracolumbar IVDE were included in this study. This was a prospective, randomized case-series. Patients were assigned to undergo an endoscopic (group 1; n = 4) or a standard open approach (group 2; n = 4) for a hemilaminectomy. A post-operative MRI was performed in all cases.ResultsConversion to an open approach was not necessary for any case in group 1. All cases had adequate spinal cord decompression on post-operative MRI. There was no significant difference in soft tissue changes noted on post-operative MRI between the two groups.DiscussionThe MIS approach to hemilaminectomies in chondrodystrophic dogs with thoracolumbar IVDE can successfully be performed to decompress the neural tissue and appears to lead to similar clinical outcomes in the early postoperative period compared to the standard open approach. Larger studies are needed to determine the potential advantages of the MIS technique compared to the standard open approach in veterinary medicine.
The Diversity of Freshwater Stygobiotic Crustaceans in the Republic of North Ossetia–Alania Provides New Evidence for the Existence of an Ancient Glacial Refugium in the North Caucasus Region
Authors: Marin Ivan N. , Palatov Dmitry M. 
Published: April 2024

A review and partial revision of the diversity of freshwater stygobiotic crustaceans in the territory of the Republic of North Ossetia–Alania, in the North Caucasus, is presented here. Previously, two species of the genus Proasellus Dudich, 1925 (Isopoda, Asellidae), P. uallagirus Palatov & Sokolova, 2020 and P. irystonicus Palatov & Sokolova, 2020, and one species of the genus Niphargus Schiödte, 1849 (Amphipoda, Niphargidae), N. alanicus Marin & Palatov, 2021, were described from the hyporhean/underground habitats (hyporhea) in the area. However, further research using an integrative approach has revealed that only a single species of the genus Proasellus (P. uallagirus) is actually widely distributed in the hyporhean riverbed habitats in the area, while the diversity of the genus Niphargus is higher than previously known. Six more new Niphargus species— namely, N. ardonicus sp. nov., N. sadonicus sp. nov., N. fiagdonicus sp. nov., N. tschertschesovae sp. nov., N. osseticus sp. nov. and N. zeyensis sp. nov., were discovered from the various hypogean underground water sources (i.e., springs and seeps) and are described in this article. Their phylogenetic relationships with their congeners, as well as their ecology and known distribution, are discussed. Furthermore, molecular genetic analysis, with an interpretation of the estimated divergence time, suggests that the studied hyporheic/stygobiotic crustaceans started to diverge from related European and Balkan sister species during the Late Miocene, approximately 8–5.8 Mya, with the reduction in the Paratethys and the uplifting of the Caucasus Mountains. Local speciation was led by local geological processes and karst fragmentation during the Late Pliocene and Early Pleistocene periods, starting around 5.3 Mya. The obtained data suggest that the mountainous area of the North Ossetia–Alania could be considered as a post-Pliocene glacial refugium for subterranean and stygobiotic fauna—the first known for the North Caucasus region.
The Conqueror of the Riverline: on a Four-Legged White Cross-Lined Predynastic Bowl from the Museo Egizio (S.1825), Turin
Authors: Baqué-Manzano Lucas 
Published: April 2024

Le présent article analyse la décoration tout à fait exceptionnelle d’un bol classe C (white cross-lined), qui se trouve au Museo Egizio de Turin. L’iconographie de sa face interne présente un très grand intérêt pour mieux comprendre les mentalités et les changements culturels des premières communautés de la vallée du Nil pendant la période prédynastique. La scène représentée dans ce bol doit être considérée comme une preuve, iconologiquement pertinente, du symbolisme animal associé à la domination de l’homme sur l’environnement du Nil, pendant la période de transition vers Nagada II. Le contrôle des animaux aquatiques hostiles, comme l’hippopotame, au-delà du conflit pour le contrôle du territoire, relève également de la confrontation avec un pouvoir surnaturel que ces groupes humains tentent de dominer et de soumettre.
De la norme ISAD(G) à Records in Contexts (RiC)
Authors: Sibille-de Grimoüard Claire 
Published: April 2024

Au cours des vingt-cinq dernières années, les fondements conceptuels, théoriques et méthodologiques de la description archivistique ont connu d’importantes évolutions. Les technologies basées sur l’Internet et les nouveaux besoins des utilisateurs en matière d’accès à l’information en ont été les principaux facteurs. La tendance est à présent à la mise en oeuvre de formats permettant un accès intégré via le web aux ressources archivistiques, bibliothéconomiques et muséales. Tout en se fondant sur les quatre normes de description du Conseil international des archives, le modèle conceptuel
Records in Contexts-Conceptual Model (RiC-CM) permet d’adopter de nouvelles approches pour la représentation, l’accès, la diffusion et la réutilisation des descriptions archivistiques en tant que données liées ouvertes.
Aspectos clínicos e terapêuticos da síndrome ascítica em galinha garnisé (Gallus gallus) (Linnaeus, 1758) – relato de caso
Authors: Santos João Victor Batista dos , Oliveira Matheus Resende , Silva Weslania Souza Inácio da , Oliveira Neto Manuel Benício , Santos Anna Luiza Hora dos , Costa Ana Cinthia Santos da , Melo Andressa de Loureiro , Carvalho Júlia Freire de , Batista Mariana de Andrade , Lima Victor Fernando Santana 
Published: April 2024

A síndrome ascítica é uma condição multifatorial que afeta aves domésticas e silvestres, caracterizada pelo acúmulo anormal de fluido na cavidade abdominal. É uma preocupação significativa na avicultura devido ao seu impacto na saúde e no desempenho das aves. Por esse motivo, o presente estudo teve como objetivo relatar os aspectos clínicos e terapêuticos da síndrome ascítica em galinha garnisé. Foi encaminhada à Clínica Veterinária Escola da Universidade Federal de Sergipe - Campus do Sertão, uma galinha garnisé adulta, fêmea, pesando 1,280 kg, devido à presença de secreção na cloaca. No exame físico, foram observados edema e secreção esbranquiçada na região cloacal. Com isso, inicialmente foi preconizado o uso de Fembendazol, porém, após 24 dias, houve um aumento significativo de peso e agravamento dos sinais clínicos, levando à instituição de Meloxicam, Enrofloxacina e assepsia com Clorexidina 2%, seguido de internamento. Apesar do tratamento, a galinha continuou a ganhar peso e apresentou sinais de dispneia e prostração. Após a falha inicial do tratamento, foram realizadas diversas intervenções, incluindo lavagem da região cloacal, administração de Ocitocina e Cálcio, além da celiocentese para drenagem do líquido ascítico. Este último procedimento resultou em uma melhora significativa do quadro clínico apresentado, reduzindo o seu peso para 1,039 kg. Portanto, o emprego de protocolos terapêuticos apropriados sugere a possibilidade de reversão do quadro clínico em pacientes suscetíveis a essa condição, superando desafios que podem comprometer a recuperação.
Estimation of Biomass and Below Ground Carbon in the Lepar Island Mangrove Ecosystem, South Bangka Regency
Authors: Farhaby Arthur Muhammad , Aprilita Desi , Henri Henri , Supratman Okto , Adi Wahyu , Ferizal Jemi 
Published: April 2024

Mangrove ecosystems are similar to other forest ecosystems in that they play a role in absorbing CO2 from the atmosphere. Mangrove ecosystems can store more carbon compared to most rainforests. This is because mangrove plants utilize CO2 for photosynthesis and store it in the form of biomass and sediments. The purpose of this research is to determine the potential of mangrove ecosystems in absorbing and storing carbon, particularly the content of below-ground carbon and Biomass from several locations on Lepar Island. The data collection method used systematic sampling, where the placement of sampling plots had regular distances from the sea to the land. Substrate samples were taken using a core sampler tool and analyzed using the Loss of Ignition (LOI) method to determine carbon content. The research results showed that the average soil density at all stations was 1.0 g/cm3. The average percentage of organic carbon at all stations was 0.09 C%. The average total carbon content at all stations was 105.73 tons/ha. Mangrove forests are capable of storing a large amount of carbon in both biomass and sediments.
Keywords: Belowground, Karbon, Lepar Island
Abstrak
Ekosistem mangrove sama halnya dengan ekosistem hutan lain yang memiliki peran sebagai penyerap CO2 dari atmosfer. Ekosistem mangrove mampu menyimpan lebih banyak karbon dibandingkan dengan kebanyakan hutan hujan. Hal ini dikarenakan tumbuhan mangrove memanfaatkan CO2 untuk fotosintesis dan menyimpannya dalam bentuk biomassa dan sedimen. Tujuan penelitian ini untuk mengetahui potensi ekosistem mangrove dalam menyerap dan menyimpan karbon terutama kandungan pada Belowground Carbon mangrove dan Biomassa dari beberapa lokasi yang ada di pulau lepar. Metode pengambilan data dilapangan menggunakan systematic sampling method, dimana penempatan plot sampling memiliki jarak yang teratur antar plot dari laut ke darat. Pengambilan sampel substrat menggunakan alat core sampler dan dilakukan dengan metode komposit. kemudian dianalisis kandungan karbon menggunakan metode Loss of Ignition (LOI). Hasil penelitian menunjukan nilai rata-rata densitas tanah seluruh stasiun yaitu sebesar 1,0 g/cm3. Nilai rata-rata presentase karbon organik pada seluruh stasiun yaitu sebesar 0,09 C%. Nilai rata-rata kandungan karbon total pada seluruh stasiun yaitu sebesar 105,73 ton/ha. Hutan mangrove mampu menampung kandungan karbon dengan jumlah besar baik di biomassa dan sedimen.
Kata Kunci :Belowground, Karbon, Pulau Lepar
Pendidikan Kesehatan Gerakan Masa Depan Sehat Dengan Mencegah Dan Kendalikan Si Manis Berujung Kronis (Diabetes Melitus) Sejak Dini Di Banjar Umahanyar, Abiansemal, Badung
Authors: Wijaya I Putu Artha , Widarma Atmaja I Komang , Ayu Septia Dewi Ni Kadek 
Published: April 2024

Diabetes Melitus (DM) adalah penyakit genetik dan terjadi ketika kadar gula dalam darah tidak berada pada nilai seharusnya yang bisa disebabkan karena sekresi insulin, cara kerja insulin atau bahkan bisa gabungan dari keduanya (Ryadi, Prabowo and Defi, 2017). Hasil Riset Kesehatan Dasar (Riskesdas) diketahui adanya peningkatan prevalensi DM pada tahun 2018 dibandingkan tahun 2013 dari 1,1% meningkat menjadi 2,1%. Kemudian prevalensi DM yang terdiagnosis dokter di Provinsi Sumatera Barat mencapai 1,3% dan 1,4% di Kota Padang (2). Faktor risiko diabetes mellitus di bagi 2, yaitu factor risiko yang tidak dapat dimodifikasi dan factor risiko yang dapat dimodifikasi.
Tujuan kegiatan pengabdian ini adalah untuk agar masyarakat mengetahui dan paham tentang penanggulangan dan pencegahan diabetes mellitus sehingga dapat mencegah dan menurunkan komplikasi dari diabetes melitus.`Penatalaksanaan diabetes mellitus untuk mencegah terjadinya komplikasi menurut (Indonesia, 2015) adalah dengan latihan jasmani.
Hasil pengabdian ini menunjukkan sebelum diberikan penyuluhan 11 orang (39.3%) yang memiliki pengetahuan kurang dan 2 orang (7.1%) memiliki pengetahuan baik, sedangkan setelah diberikan penyuluhan 5 orang (17.9%) memiliki pengetahuan cukup, dan 23 orang (82.1%) memiliki pengetahuan baik. Kesimpulan, pemberian penyuluhan tentang pubertas meningkatkan pengetahuan remaja sebanyak 82.1% dibandingkan sebelum diberikan penyuluhan.
Predictors of long-term remission in acromegaly – an updated review
Authors: Tomasik Agnieszka , Stelmachowska-Banaś Maria , Zgliczyński Wojciech 
Published: April 2024

Abstract
Acromegaly is a rare chronic disorder due to growth hormone (GH) - secreting pituitary tumor. The first-line treatment of acromegaly is a transsphenoidal adenomectomy. Surgical remission rates range from 30-50% for macroadenomas to 70-90% for microadenomas. Thus in patients with active acromegaly after surgery, medical treatment is recommended. Treatment outcome on medical therapy differs a lot depending on medications.
The aim of this paper is to summerize the current knowledge of factors predicting acromegaly remission after surgery and biochemical control on medical treatment.
Factors affecting treatment outcome, not related to the patient and the tumor, are neurosurgeon’s experience and visualisation tools used during surgery. Younger patients, as well as women tend to achieve acromegaly remission after surgery less often. Patients with lower GH and insulin-like growth factor-1 (IGF-1) concentrations at diagnosis, in oral glucose tolerance test (OGTT) and postoperatively have a greater chance of surgical remission. However, some publications do not confirm that. Patients presenting with larger and more invasive tumors achieve surgical remisson less often. Hypointensive tumors on T2-weighted magnetic resonance imaging (MRI) scans are associated with better response to first-generation somatostatin receptor ligands (SRLs) and to pasireotide. Pathologic factors increasing the chance of acromegaly remission are densely granulated tumors, lower Ki-67 index, high expression of somatostatin receptors (SSTRs) and high expression of E-cadherin.
A thorough analysis of the abovementioned factors predicting the treatment outcome in acromegaly may be helpful for selecting the best treatment option for each patient.
PENGEMBANGAN MODUL AJAR DENGAN PENDEKATAN KONTEKSTUAL UNTUK MENINGKATKAN HASIL BELAJAR FISIKA MATERI ANALISIS GERAK DENGAN VEKTOR
Authors: Siung Magdalena , Nasar Adrianus , Dala Ngapa Yulius Saprianus 
Published: April 2024

Tujuan penelitian ini yaitu untuk mengetahui kelayakan dan keefektifan modul ajar terhadap hasil belajar fisika siswa kelas XI A3 SMA Negeri 1 Ende tahun pelajaran 2023/2024. Jenis penelitian yang digunakan adalah Research and Development dengan desain 4D (Define, Design, Development, Disseminate). Subjek penelitian yaitu uji coba dari 4 orang validator yang terdiri dari 2 dosen sebagai ahli media dan 2 orang guru mata pelajaran fisika sebagai ahli materi, serta 36 siswa kelas XI A3 SMAN 1 Ende. Pengumpulan data dilakukan dengan lembar angket dan pretes-posttes. Analisis data dengan menggunakan statistik deskriptif sederhana dan menggunakan uji t. Hasil dari penelitian menunjukkan bahwa materi berkategori sangat layak (83,35%), modul ajar sebagai media berkategori sangat layak (85,63%) dan modul ajar respon siswa berkategori sangat layak (96%). Pembelajaran fisika dengan menggunakan modul ajar pendekatan kontekstual dapat berpengaruh terhadap hasil belajar fisika siswa SMA Negeri 1 Ende tahun pelajaran 2023/2024. Hal ini dibuktikan dengan hasil perhitungan dengan menggunakan software SPSS versi 24 yaitu nilai sig (2-tailed) atau (0,000 kurang dari 0,05) pada = 5% dan dk= 36, dan t = -8,790. Hal ini menunjukan bahwa modul ajar dengan pendekatan kontekstual layak dan efektif untuk digunakan.
Pengaruh Latihan Kekuatan Otot Lengan terhadap Ketepatan Smash dalam Permainan Bola Voli SMAN 1 Wonosari
Authors: Bokingo Al Iman , Mile Sarjan , Amri Muhammad Faisal Lutfi , Pakaya Rosbin 
Published: April 2024

Penelitian ini terdiri dari dua variabel yaitu variabel bebas dan variable terikat. Variabel bebas adalah Latihan kekuatan otot lengan ( Push up) dan variabel terikat yaitu Ketepatan Smash. Instrumen penelitan mengunakan instrumen tes Ketepatan smash . Teknik pengumpulan data yaitu Pre-test, Treatment, Post test. Pre-test yaitu tes awal smash sebelum diberi perlakuan Latihan push up selama kurun waktu 2 bulan dengan frekuensi 3 kali seminggu. Post-test yaitu tes ketepatan smash setelah diberikan perlakuan ( treadment). Teknik analisa data adalah dengan menggunakan rumus Uji t pada taraf signifikan a=0,05 dalam analisa data pengujian hipotesa, diperoleh t tabel senilai 1.76 sesuai kriteria pengujian bahwa terima Ho jika t hitung sama atau lebih kecil dari ttabel. Sedangkan tolak Ho jika thitung lebih besar dari ttabel. Oleh karena itu thitung 17,64 lebih besar dari t tabel (1,76), maka analisis menunjukan tolak Ho yang berarti terima Ha atau terima hipotesis penelitian. Dengan demikian disimpulkan analisa adalah terdapat pengaruh latihan kekuatan otot lengan terhadap ketepatan smash dalam permainan bola voli di Sma N 1 Wonosari.