bluuebunny/crossref_metadata_2025_split huggingface dataset:
Efficacy of ABT-116, an antagonist of transient receptor potential vanilloid type 1, in providing analgesia for dogs with chemically induced synovitis
Authors: Cathcart Curtis J. , Johnston Spencer A. , Reynolds Lisa R. , Al-Nadaf Sami , Budsberg Steven C. 
Published: December 2011

Abstract
Objective—To investigate the ability of ABT-116 (a proprietary antagonist of transient receptor potential vanilloid type 1) administered at 2 doses to attenuate lameness in dogs with experimentally induced urate synovitis.
Animals—8 purpose-bred mixed-breed dogs.
Procedures—In a 4-way crossover study, dogs orally received each of low-dose ABT-116 treatment (LDA; 10 mg/kg), high-dose ABT-116 treatment (HDA; 30 mg/kg), firocoxib (5 mg/kg), and no treatment (nontreatment) once a day for 2 days, in a randomly assigned order. Synovitis was induced on the second day of each treatment period by intra-articular injection of either stifle joint with sodium urate, alternating between joints for each treatment period, beginning with the left stifle joint. Ground reaction forces, clinical lameness scores, and rectal temperature were assessed before the injection (baseline) and at various points afterward.
Results—Lameness scores at the 2-, 6-, and 12-hour assessment points were higher than baseline scores for HDA and nontreatment, whereas scores at the 2- and 6-hour points were higher than baseline scores for LDA. For firocoxib, there was no difference from baseline scores in lameness scores at any point. Compared with baseline values, peak vertical force and vertical impulse were lower at 2 and 6 hours for HDA and nontreatment and at 2 hours for LDA. No changes in these values were evident for firocoxib. The HDA or LDA resulted in higher rectal temperatures than did treatment with firocoxib or nothing, but those temperatures did not differ among treatments.
Conclusions and Clinical Relevance—HDA had no apparent effect on sodium urate–induced lameness; LDA did attenuate the lameness but not as completely as firocoxib treatment. High rectal temperature is an adverse effect of oral ABT-116 administration that may be of clinical concern.
Changes in the Lower Drava River Water Quality Parameters Over 24 Years
Authors: Gvozdić Vlatka , Brana Josip , Puntarić Dinko , Vidosavljević Domagoj , Roland Danijela 
Published: December 2011

Changes in the Lower Drava River Water Quality Parameters Over 24 YearsThe goal of this study was to analyse 13 physico-chemical and microbiological parameters of the Drava River water at three sampling sites in the lower Drava region (eastern Croatia) over two distinct periods: the pre-war period between 1985 and 1992 and the post-war period between 1993 and 2008. Over both periods, most parameters kept within the tolerable water quality limits, while NO3-N, NH4-N and BOD5were higher. The lower Drava showed slight organic pollution with high concentrations of dissolved oxygen. High levels of total coliforms and heterotrophic bacteria in the post-war period were only found downstream of the town of Osijek. Upstream of Osijek, the river showed a tendency for improvement.
Work Stress Among University Teachers: Gender and Position Differences
Authors: Slišković Ana , Seršić Darja 
Published: December 2011

Work Stress Among University Teachers: Gender and Position DifferencesThe aim of this study was to investigate exposure to stress at work in university teachers and see if there were differences between men and women as well as between positions. The study was carried out online and included a representative sample of 1,168 teachers employed at universities in Croatia. This included all teaching positions: assistants (50 %), assistant professors (18 %), associate professors (17 %), and full professors (15 %). Fifty-seven percent of the sample were women. The participants answered a questionnaire of our own design that measured six groups of stressors: workload, material and technical conditions at work, relationships with colleagues at work, work with students, work organisation, and social recognition and status. Women reported greater stress than men. Assistant professors, associate professors, and full professors reported greater stress related to material and technical conditions of work and work organisation than assistants, who, in turn, found relationships with colleagues a greater stressor. Full professors, reported lower exposure to stress at work than associate professors, assistant professors, and assistants.
Application of Platelet Rich Plasma in Sports Medicine
Authors: Ficek Krzysztof , Kamiński Tomasz , Wach Ewa , Cholewiński Jerzy , Cięszczyk Paweł 
Published: December 2011

Application of Platelet Rich Plasma in Sports Medicine
Any new method of treatment is associated with high expectations for its success, particularly if the therapy is based not only on the premise of achieving a symptomatic effect, but also improving functional quality and repairing structurally damaged tissues. Platelet Rich Plasma (PRP) application was shown to be a successful catalyst in the healing process for a wide variety of conditions in animal and human models. However, its use has been controversial due to many types of the PRP definition, optimal concentration, and modalities of implementation. In the qualification of patients for PRP treatment, not only should medical indications be considered, but also the role of participation in therapy with a physiotherapist supervising physical parameters and techniques used during recovery time. Further study is required in order to define optimal handling procedures of PRP injection. Long-term follow up will reveal if the promise of this substance can be realized and implemented to maximize its potential as a therapeutic remedy.
Micropropagation of the wild legume Canavalia rosea (Sw.) DC. from coastal sand dunes
Authors: D'Cunha Melwyn , Sridhar Kandikere 
Published: December 2011

Micropropagation of the wild legume Canavalia rosea (Sw.) DC. from coastal sand dunes
The wild legume Canavalia rosea (known in India as C. maritima) grows on coastal sand dunes of Southwest India. Anthers and 8 other explant types of this species (tender pods, cotyledons of ripened beans, cotyledons of germinated dry seeds, hypocotyls, young shoot buds, nodes, internodes, and roots) were used for in vitro culture. Among them, cotyledons and hypocotyls of germinated dry seeds showed a positive response. Friable callus production was seen within 4 weeks at the cut ends of cotyledon explants in MS medium fortifed with 1 mg L-1 each of BAP and 2iP. Cotyledon explants of seedlings also showed shoot bud induction in MS medium with 0.5 mg L-1 each of BAP and 2iP. Increased shoot bud induction was seen at elevated concentrations of hormones (7-27%). Hypocotyls inserted upside down on the medium with 1 mg L-1 each of BAP and 2iP, gave rise to leafy shoots within 4 weeks. Solitary or multiple somatic embryos emerged from the 10 week-old calli of cotyledons supplemented with 1.5 mg L-1 each of BAP and 2iP. Secondary embryos were also induced in some of the somatic embryos. Hypocotyls excised from 3-5-day-old seedlings in MS medium at low concentrations of auxins, produced roots within 3 weeks. The stem cuttings treated with IBA (0.25 mg L-1) increased the percentage of rooting response. Conventional methods of propagation of C. rosea through seeds may fail due to seed dormancy and mortality of the seedlings under the hostile conditions of coastal sand dunes, thus in vitro and ex vitro culture and hardening techniques may be feasible for rehabilitation. Moreover, such cultured tissues may serve for extraction of secondary metabolites.
Design of Pareto-Optimal Radar Receive Filters
Authors: De Maio Antonio , Piezzo Marco , Iommelli Salvatore , Farina Alfonso 
Published: December 2011

Design of Pareto-Optimal Radar Receive Filters
This paper deals with the design of radar receive filters jointly optimized with respect to sidelobe energy and sidelobe peaks via Pareto-optimal theory. We prove that this criterion is tantamount to jointly minimizing two quadratic forms, so that the design can be analytically formulated in terms of a multi-objective optimization problem. In order to solve it, we resort to the scalarization technique, which reduces the vectorial problem into a scalar one using a Pareto weight defining the relative importance of the two objective functions. At the analysis stage, we assess the performance of the receive filters in correspondence of different values of the Pareto weight highlighting the performance compromises between the Integrated Sidelobe Level (ISL) and the Peak Sidelobe Level (PSL).
Integration of Optoelectronic Components with LTCC (Low Temperature Co-Fired Ceramic) Microfluidic Structure
Authors: Malecha Karol 
Published: December 2011

Integration of Optoelectronic Components with LTCC (Low Temperature Co-Fired Ceramic) Microfluidic StructureInvestigations on integration of optoelectronic components with LTCC (low temperature co-fired ceramics) microfluidic module are presented. Design, fabrication and characterization of the ceramic structure for optical absorbance is described as well. The geometry of the microfluidic channels has been designed according to results of the CFD (computational fluid dynamics) analysis. A fabricated LTCC-based microfluidic module consists of an U-shaped microchannel, two optical fibers and integrated light source (light emitting diode) and photodetector (light-to-voltage converter). Properties of the fabricated microfluidic system have been investigated experimentally. Several concentrations of potassium permanganate (KMnO4) in water were used for absorbance/transmittance measurements. The test has shown a linear detection range for various concentrations of heavy metal ions in distilled water. The fabricated microfluidic structure is found to be a very useful system in chemical analysis.
Evolutionary origin of the Asteraceae capitulum: Insights from Calyceraceae
Authors: Pozner Raúl , Zanotti Christian , Johnson Leigh A. 
Published: December 2011

• Premise of the study: Phylogenies based on molecular data are revealing that generalizations about complex morphological structures often obscure variation and developmental patterns important for understanding the evolution of forms, as is the case for inflorescence morphology within the well‐supported MGCA clade (Menyanthaceae + Goodeniaceae + Calyceraceae + Asteraceae). While the basal families share a basic thyrsic/thyrsoid structure of their inflorescences, Asteraceae possesses a capitulum that is widely interpreted as a racemose, condensed inflorescence. Elucidating the poorly known inflorescence structure of Calyceraceae, sister to Asteraceae, should help clarify how the Asteraceae capitulum evolved from thyrsic/thyrsoid inflorescences.• Methods: The early development and structure of the inflorescence of eight species (five genera) of Calyceraceae were studied by SEM, and patterns of evolutionary change were interpreted via phylogenetic character mapping.• Key results: The basic inflorescence structure of Calyceraceae is a cephalioid (a very condensed botryoid/thyrsoid). Optimization of inflorescence characters on a DNA sequence‐derived tree suggests that the Asteraceae capitulum derives from a simple cephalioid through two morphological changes: loss of the terminal flower and suppression of the cymose branching pattern in the peripheral branches.• Conclusions: Widely understood as a condensed raceme, the Asteraceae capitulum is the evolutionary result of a very reduced, condensed thyrsoid. Starting from that point, evolution worked separately only on the racemose developmental control/pattern within Asteraceae and mainly on the cymose developmental control/pattern within Calyceraceae, producing head‐like inflorescences in both groups but with very different diversification potential. We also discuss possible remnants of the ancestral cephalioid structure in some Asteraceae.
Characterization and cross application of novel microsatellite markers for a rare sedge, Lepidosperma gibsonii (Cyperaceae)
Authors: Barrett Matthew D. , Wallace Mark J. , Anthony Janet M. 
Published: December 2011

• Premise of the study: Ten polymorphic microsatellite loci for the rare sword sedge Lepidosperma gibsonii (Cyperaceae) were characterized for the future study of population structure, hybridization, and clonality.• Methods and Results: Twenty samples from each of three populations were screened with the markers to assess genetic variation. Observed population heterozygosities ranged from 0.35 to 1.00, and number of alleles observed per locus ranged from eight to 23. No departures from Hardy–Weinberg equilibrium were detected for any locus in any population. Single samples from 14 species were screened to examine the transferability of the microsatellites to other species of Lepidosperma. At least eight out of 10 loci amplified in all species tested.• Conclusions: These loci will be useful for studying genetic variation, hybridization, dispersal, and breeding systems in Lepidosperma, a ubiquitous element of the flora of southern Australia.
Hydrothermal treatment of fluorinated titanium dioxide: photocatalytic degradation of phenol
Authors: Tan Yong Nian , Wong Chung Leng , Mohamed Abdul Rahman 
Published: December 2011

ABSTRACTFluorinated titanium dioxide (F‐TiO2) was synthesized by a simple sonication–hydrothermal method. The effects of dosage of fluoride dopants, hydrothermal durations, and sonication pretreatment were investigated in this paper. F‐TiO2 samples obtained in this manner were characterized by X‐ray diffraction, Brunauer–Emmett–Teller method, transmission electron microscopy, and energy dispersive X‐ray spectroscopy. The photocatalytic activities of F‐TiO2 were evaluated by the phenol degradation in a batch‐mode fluidized bed reactor under ultraviolet irradiation. The results showed that the prepared F‐TiO2 had good crystallinity and a high proportion in the anatase phase. The highest rate of photocatalytic activity was observed when the Ti : F molar ratio (RF) was RF = 0.15 and the hydrothermal duration was 10 h. F‐TiO2 showed better photocatalytic properties than that of pure TiO2. F‐TiO2 prepared by the sonication–hydrothermal treatment showed higher photocatalytic activity as compared with F‐TiO2 prepared similarly, but in the absence of sonication. © 2011 Curtin University of Technology and John Wiley & Sons, Ltd.
CD147 induces angiogenesis through a vascular endothelial growth factor and hypoxia‐inducible transcription factor 1α–mediated pathway in rheumatoid arthritis
Authors: Wang Cong‐hua , Yao Hui , Chen Li‐na , Jia Jun‐feng , Wang Li , Dai Jing‐yao , Zheng Zhao‐hui , Chen Zhi‐nan , Zhu Ping 
Published: December 2011

AbstractObjectiveRheumatoid arthritis (RA) is an inflammatory and angiogenic disease. However, the molecular mechanisms that promote angiogenesis in RA have not been clearly identified. Our objective was to study the role of CD147 in angiogenesis and determine whether the strategy in which CD147 is suppressed might be useful in reducing angiogenesis in RA.MethodsCorrelations among expression levels of CD147, vascular endothelial growth factor (VEGF), and hypoxia‐inducible factor 1α (HIF‐1α) were determined by immunohistochemistry staining. RA fibroblast‐like synoviocytes (FLS) cells were cultured under various conditions, and the production of VEGF and HIF‐1α was examined by real‐time polymerase chain reaction and enzyme‐linked immunosorbent assay. The SCID mouse coimplantation model of RA (SCID‐HuRAg) was established, mice were treated with CD147 monoclonal antibody, infliximab, or both CD147 and infliximab, and the volume of the grafts and the average vascular density were measured and analyzed. Western blot analyses were performed to examine the potential signaling pathways.ResultsThe expression levels of CD147 showed significantly positive correlations with VEGF and HIF‐1α levels, as well as with vascular density, in RA synovium. After small interfering RNA transfection or after addition of specific antibodies for CD147, the production of VEGF and HIF‐1α were significantly reduced. The expression of VEGF and HIF‐1α decreased more after CD147 inhibition than after infliximab treatment in the engrafted tissues in SCID‐HuRAg mice. The phosphatidylinositol 3‐kinase/Akt pathway may be involved in this process.ConclusionCD147 induces up‐regulation of VEGF and HIF‐1α in RA FLS, further promotes angiogenesis, and leads to the persistence of synovitis. Inhibition of CD147 may be a promising target for novel therapeutic strategies.
Myotube orientation using strong static magnetic fields
Authors: Sakurai Tomonori , Hashimoto Ayumi , Kiyokawa Tomoko , Kikuchi Kazuki , Miyakoshi Junji 
Published: December 2011

AbstractIn this experiment, we evaluated the effects of strong static magnetic fields (SMF) on the orientation of myotubes formed from a mouse‐derived myoblast cell line, C2C12. Myogenic differentiation of C2C12 cells was conducted under exposure to SMF at a magnetic flux density of 0–10 T and a magnetic gradient of 0–41.7 T/m. Exposure to SMF at 10 T led to significant formation of oriented myotubes. Under the high magnetic field gradient and a high value of the product of the magnetic flux density and magnetic field gradient, myotube orientation increased as the myogenic differentiation period increased. At the 3 T exposure position, where there was a moderate magnetic flux density and moderate magnetic field gradient, myotube orientation was not observed. We demonstrated that SMF induced the formation of oriented myotubes depending on the magnetic flux density, and that a high magnetic field gradient and a high value of the product of the magnetic flux density and magnetic field gradient induced the formation of oriented myotubes 6 days after myogenic differentiation. We did not detect any effect of the static magnetic fields on myogenic differentiation or cell number. To the best of our knowledge, this is the first report to demonstrate that myotubes orient to each other under a SMF without affecting the cell number and myogenic differentiation. Bioelectromagnetics 33:421–427, 2012. © 2011 Wiley Periodicals, Inc.
Periphery‐Substituted [4+6] Salicylbisimine Cage Compounds with Exceptionally High Surface Areas: Influence of the Molecular Structure on Nitrogen Sorption Properties
Authors: Schneider Markus W. , Oppel Iris M. , Ott Holger , Lechner Lorenz G. , Hauswald Hans‐Jochen S. , Stoll Raphael , Mastalerz Michael 
Published: December 2011

AbstractThe synthesis of various periphery‐substituted shape‐persistent cage compounds by twelve‐fold condensation reactions of four triptycene triamines and six salicyldialdehydes is described, where the substituents systematically vary in bulkiness. The resulting cage compounds were studied as permanent porous material by nitrogen sorption measurements. When the material is amorphous, the steric demand of the cages exterior does not strongly influence the gas uptake, resulting in BET surface areas of approximately 700 m2 g−1 for all cage compounds 3 c–e, independently of the substituents bulkiness. In the crystalline state, materials of the same compounds show a strong interconnection between steric demand of the peripheral substituent and the resulting BET surface area. With increasing bulkiness, the overall BET surface area decreases, for example 1291 m2 g−1 (for cage compound 3 c with methyl substituents), 309 m2 g−1 (for cage compound 3 d with 2‐(2‐ethyl‐pentyl) substituents) and 22 m2 g−1 (for cage compound 3 e with trityl substituents). Furthermore, we found that two different crystalline polymorphs of the cage compound 3 a (with tert‐butyl substituents) differ also in nitrogen sorption, resulting in a BET surface area of 1377 m2g−1, when synthesized from THF and 2071 m2g−1, when recrystallized from DMSO.
Non‐coding RNAs as theranostics in human cancers
Authors: Redis Roxana S. , Berindan‐Neagoe Ioana , Pop Victor I. , Calin George A. 
Published: December 2011

AbstractTheranostics was coined originally as a term used to describe a system that combines diagnosis and therapy, aiming to provide the tools for personalized medicine. This review reasserts the grounds for regarding non‐coding RNAs (ncRNA) as theranostics in human cancers. The microRNAs (miRNAs) are the most well studied ncRNAs in recent years; their pivotal role in orchestrating tumor initiation and progression has been confirmed in all types of cancers. Hence, these small ncRNAs have emerged as attractive therapeutic targets and diagnostic tool. Various approaches to use their therapeutic potential have been taken, here we summarize the most important ones. In the near future, the focus of theranostics will be shifted towards longer and mechanistically more versatile ncRNAs, and we included some recent advances supporting this view. J. Cell. Biochem. 113: 1451–1459, 2012. © 2011 Wiley Periodicals, Inc.
Influence of soil temperature and soil compaction on growth and P uptake of sugar beet
Authors: Hoffmann Christa , Jungk Albrecht 
Published: December 2011

AbstractSugar beet growth is often impaired by cold and compacted soil. The aim of this study was to determine the effect of soil temperature and soil compaction on the growth and function of sugar beet roots. For this purpose a pot experiment with sugar beet (Beta vulgaris) was conducted in a growth chamber in which the soil temperature was kept constant either at 10°C or 20°C and air temperature at 20°C. The soil was uncompacted (1.30 g cm−3) or compacted to a bulk density of 1.65 g cm−3. In order to find out whether growth restriction was caused by insufficient P supply of the plant the experiment was run without and with P application (300 mg per kg soil).Root growth was much smaller at 10°C compared to 20°C, whereas root/shoot ratio was not affected by soil temperature. Hence, root and shoot growth was inhibited to the same extent. P content of the plants was not reduced, neither by cold nor by compacted soil, although parameters of acquisition such as root length and morphological root properties were altered. Soil temperature strongly affected P influx, whereas compaction did not. The calculation with a simulation model showed that at 10°C soil temperature the predicted P uptake of the plants agreed with the measured P uptake irrespective of compaction and P application. However, at 20°C the model underestimated the P influx at low soil P availability even if allowance was made for root hairs. It is concluded that under conditions of high shoot P demand and low P availability in soil P has been mobilized by mechanisms not taken into account by the model.
Ein Bestimmungsschlüssel für natürliche und technogene Substrate in Böden städtisch‐industrieller Verdichtungsräume
Authors: Meuser Helmut 
Published: December 2011

AbstractDie Böden der urban‐industriellen Verdichtungsräume sind in den meisten Fällen anthropogen geformt. Sie bestehen häufig aus Gemengen von umgelagerten natürlichen und technogenen Substraten. Die Ansprache der Substrate stellt für den Bodenkartierer ein Problem dar, da keine Identifikationsmerkmaie insbesondere der technogenen Substrate zusammenfassend vorliegen. Zur Verbesserung der Arbeit des Bodenkartierers im Gelände wurde deshalb ein Bestimmungsschlüssel zum Erkennen der im urbanen Raum anzutreffenden Substrate entworfen.