bluuebunny/crossref_metadata_2025_split huggingface dataset:
Construction of Physical Education Evaluation System Based on Fuzzy Neural Network Modeling
Authors: Wang Hua Wang Hua 
Published: June 2024

Abstract

As a frontier concept of current basic education, subject literacy indicates that our country has established the direction of curriculum reform aiming at developing students' core literacy. The core subject literacy is not only the basic subject literacy gradually developed by students in the course of subject learning, but also the comprehensive factors such as character and ability gradually formed by students in extracurricular social practice activities, which is an important indicator of the new curriculum education reform. In view of the fact that the special teaching connotation of high school physical education still needs to be clarified, the evaluation methods of teaching effect still need to be enriched, and the teaching reform theory needs to be further improved. Focus on cultivating college students' lifelong sports awareness, mastering sports knowledge and skills, and developing their physical fitness, good sports behavior and sports moral quality healthily. According to the characteristics of physical education learning evaluation, the fuzzy neural network is selected to model, and the physical education teaching evaluation system is constructed. The adaptive fuzzy neural system is used to process the data, thus realizing the intelligence and automation of physical education teaching evaluation. Finally, the artificial neural network and adaptive fuzzy neural system are used in the evaluation and modeling of physical education teaching, and the experimental simulation comparison and performance analysis of the two models show that the model has good evaluation ability.
m1A-regulated DIAPH3 promotes the invasiveness of colorectal cancer via stabilization of KRT19
Authors: Mi Shuyi , Hu Jie , Chen Wenwen , Chen Jingyu , Xu Zhipeng , Xue Meng 
Published: June 2024

Abstract

Background: In recent years, the emphasis has shifted to understanding the role of N1-methyladenosine (m1A) in tumor progression as little is known about its regulatory effect on mRNA and its role in the metastasis of colorectal cancer (CRC).
Methods: We performed methylated RNA immunoprecipitation sequencing of tumor tissues and tumor-adjacent normal tissues from three patients with CRC to determine the m1A profile of mRNA in CRC. The expression of diaphanous-related formin 3 (DIAPH3) and its correlation with clinicopathological characteristics of CRC were evaluated using immunohistochemistry and online datasets. The role of DIAPH3 in the migration and invasion of CRC cells was evaluated using wound healing assay, Transwell assay and xenograft metastatic model. The downstream targets of DIAPH3 were screened using mass spectrometry. By co-transfecting DIAPH3 siRNA and a keratin 19 (KRT19) ectopic plasmid into CRC cells, the role of DIAPH3-KRT19 signaling axis was confirmed.
Results: The mRNA level of DIAHP3 and its m1A modifications increased simultaneously in the CRC tissues. In addition, high DIAPH3 expression in CRC tissues is significantly associated with metastasis and progression to an advanced stage. After the knockdown of DIAPH3, the migration and invasion capabilities of CRC cells suffered a notable decline, which could be rescued by overexpressing KRT19. In addition, the proteasome inhibitor MG132 could block the degradation of KRT19 induced by DIAPH3 silencing.
Conclusions: Our study reveals that DIAPH3 mRNA was modified in CRC cells by m1A methylation. Silencing DIAPH3 suppresses the migration and invasion of CRC cells, potentially through the proteasome-dependent degradation of downstream KRT19.
The multiwavelength behaviour of BL Lacertae explained by a wiggling filamentary jet
Authors: Raiteri Claudia 
Published: June 2024

Abstract

Blazars are active galactic nuclei that stand out for their extreme flux variability at all frequencies, from the radio to the γ-ray band. Their emission is dominated by the non-thermal radiation coming from a relativistic jet pointing close to the line of sight, with consequent Doppler beaming. This in particular implies an apparent increase of the source brightness and a shortening of the variability time scales. Many authors have explained the flares observed in the blazar light curves in terms of intrinsic energetic processes such as shocks propagating in the jet, magnetic reconnection, and turbulence. Alternative interpretations take into consideration possible geometric effects, due to changes in the orientation of the jet, as in the case of the twisting jet model proposed in Raiteri et al. (2017, Nature 552, 374). These geometrical models are supported by several observations and numerical simulations. Recent space-VLBI radio images of the source 3C 279 suggest that blazar emission comes from rotating filamentary structures produced by plasma instabilities (Fuentes et al. 2023, Nature Astronomy, 7, 1359). Moreover, mm-VLBI imaging observations of BL Lacertae found evidence of a wiggling helical jet structure close to the core (Kim et al. 2023, Astron. & Astrophys. 680, L3), confirming earlier results (Cohen et al. 2015, Astrophys. J. 803, 3). In 2020–2021 BL Lacertae underwent an extraordinary activity phase leading to its historical optical maximum brightness (Raiteri et al. 2023, Mon. Not. R. Astron. Soc. 522, 102), providing a formidable tool to study blazar variability. In the present work, we explain the multiwavelength behaviour of BL Lacertae in terms of a twisting filamentary jet, whose better alignment with the line of sight produces the observed flares. The exceptionally well-sampled optical light curve by the Whole Earth Blazar Telescope (WEBT) is used together with radio data to reconstruct the motion of the jet emitting regions in time. The γ-ray data from the Fermi satellite confirm the geometrical picture and allow us to assess the synchrotron self-Compton nature of the γ-ray radiation. This means that γ-ray photons are produced by inverse-Compton scattering of optical photons off the same relativistic electrons that are responsible for the optical radiation through a synchrotron process. The flux behaviour of other blazars suggests that the twisting filamentary jet model can provide an explanation for the multiwavelength variability of the whole blazar class.
Cysteine allostery and autoinhibition govern human STING oligomer functionality
Authors: Li Lingyin , Chan Rebecca , Cao Xujun , Ergun Sabrina , Njomen Evert , Lynch Stephen , Ritchie Christopher , Cravatt Benjamin 
Published: June 2024

Abstract

The anti-viral and anti-cancer STING innate immune pathway can exacerbate autoimmune and neurodegenerative diseases when aberrantly activated, emphasizing a key unmet need for STING pathway antagonists. However, no such inhibitors have advanced to the clinic because it remains unclear which mechanistic step(s) of human STING activation are crucial for potent and context-independent inhibition of downstream signaling. Here, we report that C91 palmitoylation, the mechanistic target of a potent tool compound, is not universally necessary for human STING signaling, making it a poor target for drug development. Instead, we discover that evolutionarily conserved C64 is basally palmitoylated and is crucial for preventing unproductive STING oligomerization in the absence of cGAMP stimulation. The effects of palmitoylation at C64 and C91 converge on the control of intra-dimer disulfide bond formation at C148. Importantly, we show for the first time that signaling-competent STING oligomers are composed of a mixture of two species: disulfide-linked STING dimers that stabilize the oligomer, and reduced STING dimers that are phosphorylated to actuate interferon signaling. Given this complex landscape and cell type specificity of palmitoylation modifications, we conclude that robust STING inhibitors must directly inhibit the oligomerization process. Taking inspiration from STING’s natural autoinhibitory mechanism, we identified an eight amino acid peptide that binds a defined pocket at the inter-dimer oligomerization interface as a proof-of-concept human STING inhibitor, setting the stage for future therapeutic development.
Simulation of flood associated with extreme rainfall events over the urban city, Bengaluru, India
Authors: Purwar Smrati , Mohapatra Gyanendranath , V Rakesh 
Published: June 2024

Abstract

Bangalore city witnessed many flash floods associated with extreme rainfall events (EREs) in the recent past. Our analysis showed an increasing trend in the annual and monthly average rainfall over major valleys in Bengaluru Urban from 1971 to 2020 which indicated the possibility of rise in the frequency of urban flooding in recent decades. The digital elevation map (DEM) is examined to understand the topography of high elevation and low-lying areas, enabling the assessment of flood impacts of EREs in various areas of Bengaluru Urban. We have selected four flash flood events associated with EREs over one of the critically low laying Koramangala-Challaghatta watershed valley (KC valley) in the city for our simulation study. To understand the flood pattern, timing and volume during these flood events, stormwater management model (SWMM) simulations were conducted with observed rainfall from rain gauge stations. The model simulations could capture the inundation prone regions of KC valley for the flood events of different rainfall intensity. The hyetograph of the rainfall runoff with elapsed time demonstrates the model capability to calculate the runoff amount for different intensity of EREs. The bias in simulated storm water discharge range from +4 to -4 cubic meter per second (CMS) at different time scales and intensities within specific areas of stormwater drainage network system. The flood modeling systems like the one presented in this study can serve as valuable decision support system for management of urban floods associated with EREs and planning of mitigation strategies.
Recurrence risk of basal cell carcinoma of the eyelid with regard to demographic and clinical patient data
Authors: Wisdorf Konstantin , Rokohl Alexander C. , Fan Wanlin , Heindl Ludwig M. 
Published: June 2024

Abstract

Purpose: To describe the demographic features of patients affected by basal cell carcinomas of the eyelid and the clinical features of the tumors, as well as to examine the correlation between these features and the recurrence rate.
Methods: This is a retrospective series of 118 cases of basal cell carcinoma of the eyelid that underwent surgical excision between January 1, 2009, and December 31, 2015. The inclusion criteria were a minimum follow-up of one year and a histopathological confirmed basal cell carcinoma. The study recorded demographic and clinical characteristics. These characteristics were then statistically analyzed to determine any significant correlation to the recurrence rate.
Results: 20 patients (16.95%) experienced tumor recurrence, with one case recurring twice during the observation period. Out of 118 cases, all but two basal cell carcinomas presented clear resection margins after one or more excisions. None of the characteristics of the patients and basal cell carcinomas showed a significant correlation to the recurrence rate (p values <0.05). Cases with sclerodermiform and superficial subtypes, recurrent basal cell carcinomas, positive resection margins or horizontal tumor diameters more than 5mm presented higher recurrence rates than other cases.
Conclusion: Standard surgical procedures can achieve low recurrence rates, provided that the resection margins are clear. In a sample with a comparatively low rate of positive resection margins (1.69%) after the operation, none of the analyzed variables were found to significantly correlate with the recurrence rate. This highlights the importance of clear resection margins in the surgical therapy of basal cell carcinoma.
Serum secreted EMC10 (scEMC10) levels are inversely associated with metabolically active brown adipose tissue in humans
Authors: Wang Xuanchun , Miao Qing , Wang Yahao , Zhang Qiongyue , Wu Wei , Yu Yifei , Zeng Fangfang , Yang Yehong , Zuo Chuantao , Guan Yihui , Liew Chong Wee , Blüher Matthias , Li Yiming 
Published: June 2024

Abstract

Background/Objectives: Secreted endoplasmic reticulum membrane complex subunit 10 (scEMC10) has been implicated in obesity in mice and humans. In this study, the associations of serum scEMC10 levels with thermoneutrality-modulated brown adipose tissue (BAT) activity and thyroid hormone (TH)-dependent thermogenesis were investigated in humans.
Subjects/Methods: Serum scEMC10 levels were measured in participants from manifold cohorts using enzyme-linked immunosorbent assay, including participants with or without active BAT determined by PET-CT scanning, BAT-positive participants before and after thermoneutrality, and patients with hyperthyroidism before and after an anti-thyroid drug treatment. The difference in serum scEMC10 between BAT-positive and -negative participants, and the changes of serum scEMC10 in BAT-positive participants before and after thermoneutrality and in patients with Grave’s disease-caused hyperthyroidism before and after an anti-thyroid drug (ATD) treatment were determined.
Results: 18F-FDG PET–CT scanning indicated BAT-positive participants were significantly younger and leaner than BAT-negative ones. There was, however, no significant difference in serum scEMC10 between the two groups. Serum scEMC10 levels in BAT-positive participants were significantly elevated by 2-hour thermoneutrality (P = 0.0017), concomitant with disappearance of active BAT. No significant association of serum scEMC10 with serum levels of either TSH, FT3, or FT4 was observed in participants from both Chinese and White cohorts. ATD treatment normalized thyroid function and reduced the uptake of 18F-FDG in skeletal muscle of patients with hyperthyroidism. Serum scEMC10 concentration, however, remained unchanged in these patients before and after ATD treatment.
Conclusions: Serum scEMC10 levels are inversely associated with metabolically active BAT, suggesting scEMC10 a suppressive role in facultative thermogenesis in humans. This finding implicates inhibition of scEMC10 in the treatment of obesity and its associated cardiometabolic diseases.
The Impact of Benson's Relaxation Technique on the Quality of Life of Operating Room Nurses in Hospitals Southwest Iran: A Randomized Controlled Trial
Authors: Mohebbi Zinat , Ghanbarzadeh Sina , Ejraei Alireza , Gheisari Somaye , Hosseini Fahimeh Alsadat 
Published: June 2024

Abstract

Background In clinical settings, continuous changes lead to increased professional stress, affecting the quality of life of nurses. Some complementary interventions may influence the improvement of the quality of life. This study aimed to determine the effect of Benson's relaxation technique on the operating room nurses’ quality of life.Methods In this clinical trial, 180 operating room nurses were randomly allocated to two groups: intervention (Benson's relaxation technique) and control (routine activity). The study was conducted from December 2021 to March 2022 in hospitals affiliated with Shiraz University of Medical Sciences. Benson's relaxation technique was performed twice daily by the intervention group for 8 weeks. Quality of life was measured before and after the intervention using the SF-36 questionnaire. Data were analyzed using SPSS version 21 software, with a significance level set at a P-value of < 0.05.Results After the intervention, the results showed that Benson's relaxation technique led to an increase in the quality of life in the intervention group (P-value < 0.0001). In terms of quality-of-life dimensions, significant improvements were observed in the intervention group in the domains of physical problems (P-value = 0.026), emotional problems (P-value = 0.010), general health (P-value < 0.038), pain (P-value = 0.0001), and social functioning (P-value = 0.001). However, no significant differences were found in the dimensions of physical functioning (P-value = 0.294), energy (P-value = 0.078), and emotional well-being (P-value = 0.087).Conclusions Benson's relaxation technique can serve as a complementary method to enhance various dimensions of the operating room nurses’ quality of life.Trial Registration Number: IRCT20211002052650N1 with the Clinical Trial Registry (26.10.2022)
Coupled Flow CEEMDAN-SSA-BiLSTM-based predictive model
Authors: Zhang Xianqi , Zheng Yupeng , Yang Yang , Liu Yike , Yan Kaiwei 
Published: June 2024

Abstract

Flow is one of the important hydrological elements to study the water ecology and water environment of rivers in nature. Predicting flow is crucial for gathering valuable research data to aid in flood prevention, mitigation efforts, and the sustainable harnessing and utilization of water resources in the basin. To enhance the accuracy of flow prediction, a novel approach has been proposed. This methodology integrates the Adaptive Noise Complete Ensemble Empirical Modal Decomposition (CEEMDAN) with a Long and Short-Term Memory (LSTM) model, further refined through the application of the Sparrow Search Algorithm (SSA). The result is a powerful and innovative Combined Runoff Prediction Model, referred to as CEEMDAN-SSA-BiLSTM. This integrated model aims to provide more reliable predictions for both long and short-term runoff scenarios, contributing to more effective water resource management and environmental preservation in the basin. The daily flow trends from 2016 to 2022 were analyzed at four hydrological stations, namely Huayuankou, Jiahetan, Gaocun, and Lijin. The overall process is to use 80% daily flow data trained to predict 20% daily flow. Combined with the evaluation indexes used, the final series of results obtained are compared with the prediction results of several models, such as LSTM, BiLSTM, and CEEMDAN-BiLSTM, in multiple ways. The ultimate comparative outcomes demonstrate that the CEEMDAN-SSA-BiLSTM coupling exhibits a notable level of accuracy in forecasting daily flow. It has less error compared to several other models.
The effect of climatic conditions on the seasonality of pest insect populations in Eucalyptus plantations in the Neotropics
Authors: Costa Erika Carla Moraes da , Silva Daniel Paiva , Lodi Sara , Simões Daniel Albeny , Godoy Bruno Spacek 
Published: June 2024

Abstract

Eucalyptus (Eucalyptus spp., Mirtaceae) stands out for its remarkable regeneration capacity, making it a valuable tool for recovering degraded areas and reforestation. Despite its origins in Australia, eucalyptus has shown remarkable adaptation to the Brazilian tropical climate, contributing significantly to the wood productivity of the country. However, the extensive monoculture of eucalyptus can increase the incidence of pests, representing a significant challenge for the forestry sector, with production losses of up to 30%. In our study, we analyzed the occurrence of 11 pest insect species in 450 eucalyptus stands over nine years in the southeastern region of Brazil. We related pest occurrences to specific year periods and climatic variations using circular uniformity analysis and zero-inflated models. We found that the species generally have isolated peaks of occurrence during the year and that the increase in the occurrence of at least five species was related to temperature or rainfall. The results highlight the sensitivity of pests to climatic conditions, showing the importance of management strategies to ensure the sustainability and productivity of eucalyptus plantations. We can develop more effective management strategies by understanding how these variables interact with insect populations, contributing to the sustainability and productivity of eucalyptus plantations with less aggressive environmental practices.
Contribution of Simulation-Based Learning in Advanced Cardiopulmonary Resuscitation for Undergraduate Medical Students
Authors: Laajimi Sondes , Bradai Haifa , Mbarek Rabeb , Chebbi Nabil , Mastouri Omar , Chebili Naoufel , Loghmari Dorra , Naija Walid 
Published: June 2024

Abstract

Background
Healthcare simulation has become a crucial pedagogical technique across various medical disciplines.This approach use, virtual reality, or standardized patients to replicate clinical scenarios, has proven vital in preparing medical students for high-risk situations, ensuring the safety and effectiveness of critical patient management through the acquisition of technical skills, teamwork, and the ability to handle exceptional scenarios. Aims of this study wereto evaluate the theoretical knowledge of students before and after the simulation-based training (SBT) of the "Advancedcardiopulmonary resuscitation(CPR)" module, to assess their technical and non-technical skills and to describe their satisfaction.
Methods
This study, conducted at the Faculty of Medicine in Sousse, Tunisia, sought to objectively evaluate the impact of SBT on the theoretical knowledge, technical skills, and non-technical competencies of graduate Medical Students, during their advanced (CPR) training. The researchers employed a pre-experimental design, assessing students before and after the simulation-based workshops covering various CPR-related topics.
Results
We have demonstrated that the SBT was highly valued by the learners and led to significant improvements in their theoretical knowledge,There is a positive correlation between the pre and post-test score, with a correlation coefficient of r = 0.474, p < 0.0001, r² = 0.245. For technical skills, (69.8%) have improving their external cardiac massage (ECM) technique by the exam day, while 14 (16.3%) exhibited a decline (p < 0.001).Additionally, "non-technical skills"( NTS) were assessed using the Anesthesia Non-Technical Skills(ANTS) scoreamong these students, 85 (89.5%) improved their scores, while 10 (10.5%) maintained their initial score (p < 0.001).At the end of the training sessions, a strong statistically significant correlation was found between the sum of post-test scores, ANTS score, cardiac massage score, and the final score of the simulated practical “ECOS” exam (r = 0.762, p < 0.001, r²=0.581).Student satisfaction was evaluated; overall, students' impressions were predominantly excellent in over 50% of responses.
Conclusion
The study's contribution to the growing body of evidence supporting the integration of simulation-based learning in the formative years of medical education is particularly noteworthy. Simulation can accelerate skill acquisition and enhance the transition of knowledge and self-confidence when faced with real-life critical scenarios.