bluuebunny/crossref_metadata_2025_split huggingface dataset:
Case Report: The Effect of Proton Pump Inhibitor Administration on Hemodynamics in a Cardiac Intensive Care Unit
Authors: Booher Anna M. , Dorsch Michael , Gurm Hitinder S. 
Published: May 2010

AbstractEx vivostudies have suggested that high dose proton pump inhibitors (PPI) may have negative inotropic effects in myocardial tissue. We sought to investigate this concept in a real‐world clinical setting. In this case series, we enrolled critically ill patients in the coronary and cardiothoracic intensive care units who had a preexisting pulmonary artery (PA) catheter in place for hemodynamic monitoring and were on a PPI for prespecified clinical indications. Hemodynamic measurements were made at baseline and then at 15 minute intervals for 1 hour after PPI administration. A total of 18 patients were evaluated; 72% were male with a mean age of 59.9 years. A total of 9 patients were evaluated on 2 consecutive days, yielding 26 patient‐exposures to the medication. The majority of patients (72%) were receiving 1 or more inotropic agents (n= 6), a vasopressor (n= 4), or both (n= 4). When compared to baseline values, there was no significant change in mean arterial pressure (baseline 80 ± 11 mm Hg), heart rate (87 ± 11 bpm), or Fick cardiac index (2.7 ± 1.8 L/min/m2). Mean PA pressure did decrease transiently at 45 minutes following PPI administration (28.5 ± 7.7 mm Hg at baseline vs 26.5 ± 7.5 mm Hg, P = 0.017), but is unlikely to be of clinical significance. In conclusion, these data suggest that IV PPIs do not immediately impact important hemodynamic parameters and are likely safe in a high‐risk intensive care setting. Copyright © 2010 Wiley Periodicals, Inc.
Survey of Prevalence, Awareness, Treatment, and Control of Hypertension Among Chinese Governmental and Institutional Employees in Beijing
Authors: Xu Tao , Wang Yang , Li Wei , Chen Wei‐Wei , Zhu Manlu , Hu Bo , Chen Tao , Liu Bing 
Published: May 2010

AbstractBackgroundFew studies have been done on the effects that awareness, treatment, and control have on hypertension among governmental and institutional employees.HypothesisThe aim of this study was to explore prevalence, awareness, treatment and control of hypertension among governmental and institutional employees.MethodsA total of 80 governmental organizations and institutions were selected with a 2‐stage clustering sampling method in Beijing and all employees in the selected institutions were considered our study subjects. The survey questionnaires included demographic characteristics; medical, personal, and family health history; lifestyle information; and sources of blood pressure knowledge.ResultsThe ages of 30 682 subjects ranged from 18 to 65 years and averaged 40.3 ± 11.4 years. The proportion of males was 54.4% (16 702 subjects). A total of 9216 subjects were diagnosed hypertensive and the prevalence rate was 30.0%. Among hypertensive patients, 5399 subjects were aware of being hypertensive and the awareness rate was 58.6%. Although 51.7% of hypertensive subjects were taking antihypertensive medications, only 2371 subjects had their blood pressure under control (<140/90 mm Hg) and the control rate was 25.7%. Only 4915 subjects (16.0%) monitored their own blood pressure regularly. Health publications (50.6%) and families/friends (49.1%) were the main sources of hypertension knowledge. Female hypertensive subjects have more effectively controlled blood pressure than their male counterparts. Subjects with a bachelor's degree or higher had a lower awareness rate and treatment rate, but a higher control rate.ConclusionsThe percentage of hypertensive subjects who are aware, treated, and controlled are unacceptably low among Chinese governmental and institutional employees. Regular medical check‐ups and measuring of blood pressure are necessary to improve awareness, treatment, and control of hypertension. Copyright © 2010 Wiley Periodicals, Inc.
Lead Astray: Minimally Invasive Removal of a Pacing Lead in the Left Ventricle
Authors: Stouffer Chadwick W. , Shillingford Michael S. , Miles William M. , Conti Jamie B. , Beaver Thomas M. 
Published: May 2010

AbstractPacemaker and implantable cardioverter defibrillator (ICD) leads are placed routinely with few notable complications. A rarely described complication of transvenous lead placement is malpositioning into the left ventricle. This situation can cause additional complications in the form of thromboembolic events. We present a case of a malpositioned left ventricular lead that was successfully removed with a minimally invasive technique. Copyright © 2010 Wiley Periodicals, Inc.
The Causes and Outcomes of Inadequate Implementation of Existing Guidelines for Antiplatelet Treatment in Patients With Acute Coronary Syndrome: The Experience From Taiwan Acute Coronary Syndrome Descriptive Registry (T‐ACCORD Registry)
Authors: Cheng Cheng‐I , Chen Ching‐Pei , Kuan Pei‐Liang , Lei Meng‐Huan , Liau Chiau‐Suong , Ueng Kwo‐Chang , Wu Chiung‐Jen , Lai Wen‐Ter 
Published: May 2010

AbstractBackgroundBenefits of antiplatelet agents in preventing future cardiovascular events have been well established. However, the prescription pattern of antiplatelet usage in patients with acute coronary syndrome (ACS) is rarely investigated. Hence, Taiwan ACute CORonary Syndrome Descriptive Registry (T‐ACCORD Registry) aimed to evaluate medical practices in Taiwan in managing ACS patients.HypothesisThe guidelines of antiplatelet treatment is not properly implanted in the management of ACS patients.MethodsThis prospective observational study was performed between April 2004 and December 2006 in 27 hospitals in Taiwan. A total of 1331 patients with unstable angina or non–ST‐elevation myocardial infarction (NSTEMI) discharged from hospitals was analyzed.ResultsThe patients with older age, lower hemoglobin levels, or previous cardiovascular ischemic diseases were less likely to receive aspirin at discharge, whereas patients with NSTEMI were less likely to receive clopidogrel at discharge. The prescription of dual antiplatelet agents declined rapidly from 61.8% at discharge to 12.6% at 12 months. The most common reason for clopidogrel discontinuation was recorded as physician's judgment. Dual antiplatelet treatment for 9 months or longer was associated with lower 1‐year mortality. Percutaneous coronary intervention (PCI) was the only factor leading to dual antiplatelet therapy for at least 9 months.ConclusionsOur registry showed that underlying medical conditions may affect antiplatelet prescriptions at discharge. During the first year following an ACS episode, the prescription rate of dual antiplatelet therapy declined over time, mainly due to physician's judgment leading to the discontinuation of clopidogrel. Adherence to dual antiplatelet treatment was associated with lower total mortality at 1 year. Copyright © 2010 Wiley Periodicals, Inc.
Imatinib plus low‐dose doxorubicin in patients with advanced gastrointestinal stromal tumors refractory to high‐dose imatinib
Authors: Maurel Joan , Martins Ana Sofia , Poveda Andrés , López‐Guerrero José Antonio , Cubedo Ricardo , Casado Antonio , Martínez‐Trufero Javier , Ramón Ayuso Juan , Lopez‐Pousa Antonio , Garcia‐Albeniz Xabier , Garcia del Muro Xavier , de Alava Enrique 
Published: April 2010

AbstractBACKGROUND:In KIT‐expressing Ewing sarcoma cell lines, the addition of doxorubicin to imatinib increases apoptosis, compared with imatinib or doxorubicin alone. On the basis of these in vitro data, the authors conducted a phase 1‐2 trial of doxorubicin with imatinib in patients with gastrointestinal sarcoma tumors refractory to high‐dose imatinib therapy.METHODS:Patients with metastatic gastrointestinal sarcoma tumor resistant to imatinib at 400 mg by mouth (p.o.) twice a day were eligible for this multicenter study, and received imatinib (400 mg p.o. every day [q.d.]) concomitantly with doxorubicin 15‐20 mg/m2/weekly for 4 cycles (monthly cycles), followed by imatinib (400 mg p.o. q.d.) maintenance in nonprogressive patients. Spiral computed tomography and positron emission tomography with F18‐fluorodeoxyglucose were done basally and after 2 months of therapy to evaluate response. An in vitro study assessed the effect of combining imatinib and doxorubicin.RESULTS:Twenty‐six patients with progressive gastrointestinal sarcoma tumor were entered in the study. Treatment was well tolerated. Three (14%) of 22 evaluable patients had partial responses per Response Evaluation Criteria in Solid Tumors, and 8 (36%) had clinical benefit (partial response or stable disease for ≥6 months). Median progression‐free survival (PFS) was 100 days (95% confidence interval [CI], 62‐138), and median survival was 390 days (95% CI, 264‐516). Interestingly, PFS was 211 days (95% CI, 52‐370) in patients with wild type (WT)KITand 82 days (95% CI, 53‐111) in non‐WT patients (10 mutant, 6 not assessed). A synergistic effect on cell line proliferation and apoptosis was found with imatinib and doxorubicin combination.CONCLUSIONS:Low‐dose chemobiotherapy combination showed promising activity in heavily pretreated gastrointestinal sarcoma tumor patients, especially in those with WT‐KITgenotype. Cancer 2010. © 2010 American Cancer Society.
CFL1 expression levels as a prognostic and drug resistance marker in nonsmall cell lung cancer
Authors: Castro Mauro Antonio Alves , Dal‐Pizzol Felipe , Zdanov Stephanie , Soares Marcio , Müller Carolina Beatriz , Lopes Fernanda Martins , Zanotto‐Filho Alfeu , Fernandes Marilda da Cruz , Moreira Jose Claudio Fonseca , Shacter Emily , Klamt Fábio 
Published: April 2010

AbstractBACKGROUND:Nonsmall cell lung cancer (NSCLC) is the major determinant of overall cancer mortality worldwide. Despite progress in molecular research, current treatments offer limited benefits. Because NSCLC generates early metastasis, and this behavior requires great cell motility, herein the authors assessed the potential value of CFL1 gene (main member of the invasion/metastasis pathway) as a prognostic and predictive NSCLC biomarker.METHODS:Metadata analysis of tumor tissue microarray was applied to examine expression of CFL1 in archival lung cancer samples from 111 patients, and its clinicopathologic significance was investigated. The robustness of the finding was validated using another independent data set. Finally, the authors assayed in vitro the role of CFL1 levels in tumor invasiveness and drug resistance using 6 human NSCLC cell lines with different basal degrees of CFL1 gene expression.RESULTS:CFL1 levels in biopsies discriminate between good and bad prognosis at early tumor stages (IA, IB, and IIA/B), where high CFL1 levels are correlated with lower overall survival rate (P < .0001). Biomarker performance was further analyzed by immunohistochemistry, hazard ratio (P < .001), and receiver‐operating characteristic curve (area = 0.787; P < .001). High CFL1 mRNA levels and protein content are positively correlated with cellular invasiveness (determined by Matrigel Invasion Chamber System) and resistance (2‐fold increase in drug 50% growth inhibition dose) against a list of 22 alkylating agents. Hierarchical clustering analysis of the CFL1 gene network had the same robustness for stratified NSCLC patients.CONCLUSIONS:This study indicates that the CFL1 gene and its functional gene network can be used as prognostic biomarkers for NSCLC and could also guide chemotherapeutic interventions. Cancer 2010. © 2010 American Cancer Society.
The development of roof color in ancient China
Authors: Gou Aiping , Wang Jiangbo 
Published: April 2010

AbstractThe roof in ancient Chinese building is sloped roof which plays an important role in chromatic townscape. In earlier time, the colors in roofs were gray. With the development of technique in tiles making, tiles color was becoming colorful.However, the color usage in ancient architecture is regulated by hierarchy and the theory of five colors and five essences. Even there were a lot of colored glaze pieces in construction, only very few colors were used in royal and temple buildings' roof. Those regulations and laws made the characters of roof colors in different zones outstanding and legible.With specific color samples of different dynasties tested on site, and related laws and documentations analysis, as well as the theory of five colors and five essences, this article reports research on the characters of the roof colors in different periods, to draw out the turning points and reasons of roof color changes in crucial periods. © 2010 Wiley Periodicals, Inc. Col Res Appl, 2010
A formalized approach for designing a P2P‐based dynamic load balancing scheme
Authors: Xie Hengheng , Boukerche Azzedine , Zhang Ming 
Published: April 2010

AbstractQuality of service (QoS) is attracting more and more attention in many areas, including entertainment, emergency services, transaction services, and so on. Therefore, the study of QoS‐aware systems is becoming an important research topic in the area of distributed systems. In terms of load balancing, most of the existing QoS‐related load balancing algorithms focus on Routing Mechanism and Traffic Engineering. However, research on QoS‐aware task scheduling and service migration is very limited. In this paper, we propose a task scheduling algorithm using dynamic QoS properties, and we develop a Genetic Algorithm‐based Services Migration scheme aiming to optimize the performance of our proposed QoS‐aware distributed service‐based system. In order to verify the efficiency of our scheme, we implement a prototype of our algorithm using a P2P‐based JXTA technique, and do an emulation test and a simulation test in order to analyze our proposed solution. We compare our service‐migration‐based algorithm with non‐migration and non‐load‐balancing approaches, and find that our solution is much better than the other two in terms of QoS success rate. Furthermore, in order to provide more solid proofs of our research, we use DEVS to validate our system design. Copyright © 2010 John Wiley & Sons, Ltd.
The stability of a chaotic PWM boost converter
Authors: Li Hong , Li Zhong , Zhang Bo , Zheng Qionglin , Halang Wolfgang 
Published: April 2010

AbstractA novel chaotic pulse‐width‐modulation (PWM) boost converter has been previously proposed to reduce electromagnetic interference (EMI) in DC–DC converters, where the circuit design and simulations have been conducted, but the problems such as the mean value estimation of state variables for circuit parameter design, the ripple estimation of the input current and the stability analysis have been remained to be addressed in this paper. Here, a mean value estimation method is first proposed, which is used to estimate the mean values of state variables of chaotic PWM boost converters for facilitating the circuit parameter design and selection of circuit components. Although ripples are slightly increased, caused by adopting chaotic carriers, the DC–DC converter with reduced EMI is still stable under the chaotic PWM control. This work provides a theoretic verification of the effectiveness and practicability of the proposed chaotic PWM DC–DC converters. Copyright © 2010 John Wiley & Sons, Ltd.
A fully‐integrated CMOS UWB transceiver for ultra‐low‐power short‐range application
Authors: Liu Mengmeng , Zhang Sheng , Wang Shuo , Zhou Runde 
Published: April 2010

AbstractIn short‐range UWB communication systems, the low‐power design is the most important issue to make UWB technology attractive. A novel trigger receiving algorithm for UWB signals is proposed, which can reduce the system power significantly at the cost of slight performance degrade. A UWB transceiver based on the trigger receiving algorithm is designed and fabricated in HJTC 0.18 µm CMOS process with a total size of 0.45 mm2. The experimental results show that the total power consumption of the transceiver is only 12 mW at 100 Mb/s data rate from a 1.8 V supply, making it suitable for low‐power short‐range communication. Copyright © 2010 John Wiley & Sons, Ltd.
Three‐stage nested‐Miller‐compensated operational amplifiers: Analysis, design, and optimization based on settling time
Authors: Aminzadeh Hamed 
Published: April 2010

AbstractIn analog signal‐processing applications, settling performance of the employed operational amplifiers (opamps) is usually of great matter. Under low‐voltage environment of modern technologies where only a few transistors are allowed to be stacked, three‐stage amplifiers are gaining more interest. Unfortunately, design and optimization of three‐stage opamps based on settling time still suffer from lack of a comprehensive analysis of the settling behavior and closed‐form relations between settling time/error and other parameters. In this paper, a thorough analysis of the settling response of three‐stage nested‐Miller‐compensated opamps, including linear and non‐linear sections, is presented. This analysis leads to a design methodology which determines the circuit requirements for desired settling time/error. Based on settling time, it allows optimizations in power consumption and area. Copyright © 2010 John Wiley & Sons, Ltd.
BDD‐based synthesis for mixed CMOS/PTL logic
Authors: Kao Chi‐Chou 
Published: April 2010

AbstractPower consumption and performance are two important design constraints for logic synthesis in design automation. In this paper, we propose an efficient synthesis algorithm to minimize power dissipation and optimize performance of the given digital circuits by constructing a binary decision diagram (BDD) whose nodes can be implemented by CMOS logics and pass‐transistor logics (PTL) in a cell library.For BDD mapped circuits, the conventional synthesis algorithms need three cells: the CMOS cell, PTL cell, and CMOS remapping pattern. In the proposed synthesis algorithm, we first refine the cell library structure to two kinds of cells: PTL and CMOS cells. Next, a new algorithm is presented to select the suitable cells so that the areas and power dissipation can be decreased when the logic functions of the given digital circuits are mapped into BDD. The efficiency of this algorithm has been shown in the experimental results. Copyright © 2010 John Wiley & Sons, Ltd.
A QoE management system to improve the IPTV network
Authors: Lloret Jaime , Garcia Miguel , Atenas Marcelo , Canovas Alejandro 
Published: May 2010

AbstractOne of the biggest problems of the IPTV providers is to offer enough quality of experience (QoE) to their customers. The minimum bandwidth in the access network required to provide IPTV services, jointly with the necessity to guarantee the QoE to the customers, creates the need for new type of algorithms to satisfy the network requirements. Apart from the parameters that depend on the application aspect and design, the user's QoE mainly depends on the video quality (VQ), which can be affected by the network parameters (jitter, delay, lost packets, etc.), and on other parameters, such as zapping time and synchronization time. In this paper, we implement several benches to know how each measurable parameter affects the user's QoE. Taking into account these parameters, we propose an analytical expression for the QoE calculation. Then, the paper presents a network management algorithm that takes into account the information received by the user to take the appropriate actions and vary some features of the IP network to provide enough IPTV QoE to the customer. Finally, we measure how one of the actions taken by our system affects the network performance and the VQ. Copyright © 2010 John Wiley & Sons, Ltd.
Engineering and characterization of the long‐acting glucagon‐like peptide‐1 analogue LY2189265, an Fc fusion protein
Authors: Glaesner Wolfgang , Mark Vick Andrew , Millican Rohn , Ellis Bernice , Tschang Sheng‐Hung , Tian Yu , Bokvist Krister , Brenner Martin , Koester Anja , Porksen Niels , Etgen Garret , Bumol Tom 
Published: May 2010

AbstractBackgroundGlucagon‐like peptide‐1 (GLP‐1) receptor agonists are novel agents for type 2 diabetes treatment, offering glucose‐dependent insulinotropic effects, reduced glucagonemia and a neutral bodyweight or weight‐reducing profile. However, a short half‐life (minutes), secondary to rapid inactivation by dipeptidyl peptidase‐IV (DPP‐IV) and excretion, limits the therapeutic potential of the native GLP‐1 hormone. Recently, the GLP‐1 receptor agonist exenatide injected subcutaneously twice daily established a novel therapy class. Developing long‐acting and efficacious GLP‐1 analogues represents a pivotal research goal. We developed a GLP‐1 immunoglobulin G (IgG4) Fc fusion protein (LY2189265) with extended pharmacokinetics and activity.MethodsIn vitro and in vivo activity of LY2189265 was characterized in rodent and primate cell systems and animal models.ResultsLY2189265 retained full receptor activity in vitro and elicited insulinotropic activity in islets similar to native peptide. Half‐life in rats and cynomolgus monkeys was 1.5–2 days, and serum immunoreactivity representing active compound persisted > 6 days. In rats, LY2189265 enhanced insulin responses during graded glucose infusion 24 h after one dose. LY2189265 increased glucose tolerance in diabetic mice after one dose and lowered weight and delayed hyperglycaemia when administered twice weekly for 4 weeks. In monkeys, LY2189265 significantly increased glucose‐dependent insulin secretion for up to a week after one dose, retained efficacy when administered subchronically (once weekly for 4 weeks) and was well tolerated.ConclusionsLY2189265 retains the effects of GLP‐1 with increased half‐life and efficacy, supporting further evaluation as a once‐weekly treatment of type 2 diabetes. Copyright © 2010 John Wiley & Sons, Ltd.
Activation of ADF/cofilin mediates attractive growth cone turning toward nerve growth factor and netrin‐1
Authors: Marsick Bonnie M. , Flynn Kevin C. , Santiago‐Medina Miguel , Bamburg James R. , Letourneau Paul C. 
Published: April 2010

AbstractProper neural circuitry requires that growth cones, motile tips of extending axons, respond to molecular guidance cues expressed in the developing organism. However, it is unclear how guidance cues modify the cytoskeleton to guide growth cone pathfinding. Here, we show acute treatment with two attractive guidance cues, nerve growth factor (NGF) and netrin‐1, for embryonic dorsal root ganglion and temporal retinal neurons, respectively, results in increased growth cone membrane protrusion, actin polymerization, and filamentous actin (F‐actin). ADF/cofilin (AC) family proteins facilitate F‐actin dynamics, and we found the inactive phosphorylated form of AC is decreased in NGF‐ or netrin‐1‐treated growth cones. Directly increasing AC activity mimics addition of NGF or netrin‐1 to increase growth cone protrusion and F‐actin levels. Extracellular gradients of NGF, netrin‐1, and a cell‐permeable AC elicit attractive growth cone turning and increased F‐actin barbed ends, F‐actin accumulation, and active AC in growth cone regions proximal to the gradient source. Reducing AC activity blunts turning responses to NGF and netrin. Our results suggest that gradients of NGF and netrin‐1 locally activate AC to promote actin polymerization and subsequent growth cone turning toward the side containing higher AC activity. © 2010 Wiley Periodicals, Inc. Develop Neurobiol 70: 565–588, 2010