bluuebunny/crossref_metadata_2025_split huggingface dataset:
Consensus statement on extracellular vesicles in liquid biopsy for advancing laboratory medicine
Authors: Dong Xingli , Lin Yusheng , Li Kai , Liang Gaofeng , Huang Xiaoyi , Pan Jingxuan , Wang Lu , Zhang Dongmei , Liu Tingjiao , Wang Tong , Yan Xiaomei , Zhang Long , Li Xiaowu , Qu Xiujuan , Jia Da , Li Yong , Zhang Hao 
Published: June 2024

Abstract
Extracellular vesicles (EVs) represent a diverse class of nanoscale membrane vesicles actively released by cells. These EVs can be further subdivided into categories like exosomes and microvesicles, based on their origins, sizes, and physical attributes. Significantly, disease-derived EVs have been detected in virtually all types of body fluids, providing a comprehensive molecular profile of their cellular origins. As a result, EVs are emerging as a valuable addition to liquid biopsy techniques. In this collective statement, the authors share their current perspectives on EV-related research and product development, with a shared commitment to translating this newfound knowledge into clinical applications for cancer and other diseases, particularly as disease biomarkers. The consensus within this document revolves around the overarching recognition of the merits, unresolved questions, and existing challenges surrounding EVs. This consensus manuscript is a collaborative effort led by the Committee of Exosomes, Society of Tumor Markers, Chinese anti-Cancer Association, aimed at expediting the cultivation of robust scientific and clinically applicable breakthroughs and propelling the field forward with greater swiftness and efficacy.
CNT/TiO2 nanocomposite for environmental remediation
Authors: Parangi Tarun 
Published: June 2024

Abstract
Nanomaterials and their composites have been proven to be effective materials for various energy and environmental applications. In this way, functionalized polymers and their nanocomposites (NCs) are receiving much attention due to their tunable physico-chemical characteristics, cost and ease of availability. As an environmental application, particularly the removal of toxic dyes, photocatalysis has been reported as an emerging technology. The literature survey shows that functionalized polymer nanocomposites (PNCs) as photocatalysts offer an extensive contribution towards the generation of clean, renewable, and practical forms of energy from light-based pollutant removal as environmental remediation. Here, the present concept provides a brief introduction to the field of photocatalysis and environmental remediation, followed by the application of functionalized PNCs. In this view, TiO2–NCs are reported to be effective photocatalytic materials. In the present study, CNT-doped TiO2 NCs samples have been prepared using the sol–gel method and their photocatalytic activity has been investigated through a dye degradation experiment. Compared to the present studies, here the CNT content taken is very low, and it is found to be effective for the dye degradation part of an environmental cleaning application.
The crystal structure of 6-amino-2-carboxypyridin-1-ium perchlorate, C6H7ClN2O6
Authors: Xing Yalong , Huang Guang 
Published: June 2024

Abstract
C6H7ClN2O6, monoclinic, P21/c (no. 14), a = 9.2699(5) Å, b = 12.5329(6) Å, c = 7.9536(5) Å, β = 99.472(6)°, V = 911.44(9) Å3, Z = 4, R
gt(F) = 0.0442, wR
ref (F
2) = 0.1120, T = 292.98(10) K.
The crystal structure of 1,3,5-tri(1H-imidazol-1-yl)benzene–2,3,5,6-tetrachlorobenzene-1,4-dicarboxylic acid (1/1)
Authors: Wang Airong , Wang Xiaoli , Wang Yanfei , Shi Zhongfeng , Li Jiaming 
Published: June 2024

Abstract
C23H14Cl4N6O4, triclinic, P1̄ (no. 2), a = 9.044(2) Å, b = 11.340(2) Å, c = 11.812(3) Å, α = 95.470(17)°, β = 105.46(2)°, γ = 90.084(18)°, V = 1161.8(5) Å3, Z = 2, Rgt
(F) = 0.0914, wRref
(F
2) = 0.2547, T = 296 K.
Crystal structure of (E)-N-(2-bromophenyl)-4-(4-(3,5-dimethoxystyryl)phenoxy)pyrimidin-2-amine, C26H22BrN3O3
Authors: Sun Wuji , Sun Lixin , Yan Hong 
Published: June 2024

Abstract
C26H22BrN3O3, monoclinic, P21/c (no. 14), a = 17.7467(15) Å, b = 10.7974(8) Å, c = 11.9136(8) Å, β = 96.084°, V = 2270.0(3) Å3, Z = 4, Rgt
(F) = 0.0375, wRref
(F
2) = 0.1205, T = 293 K.
Stochastic maximum principle for partially observed optimal control problem of McKean–Vlasov FBSDEs with Teugels martingales
Authors: Kaouache Rafik , Lakhdari Imad Eddine , Djenaihi Youcef 
Published: June 2024

Abstract
In this paper, we study the stochastic maximum principle for a partially observed optimal control problem of forward-backward stochastic differential equations (FBSDEs for short) of McKean–Vlasov type driven by both a family of Teugels martingales and an independent Brownian motion.
The coefficients of the system and the cost functional depending on the state of the solution process as well as its probability law and the control variable.
We establish partially observed necessary conditions of optimality for this system under assumption that the control domain is supposed to be convex.
Our main result is based on Girsavov’s theorem and the derivatives with respect to probability law.
As an application of the general theory, a partially observed linear-quadratic control problem of McKean–Vlasov type is studied in terms of stochastic filtering.
Development of biogenic mediated Ag/ZrO2 nanocomposite photocatalyst for degradation of toxic dyes in textile effluents
Authors: Vanasundari Karuppaiya , Paramasivam Sivaprakash , Viji Arangarajan , Husain Fohad Mabood , Sankaran Esakki Muthu , Kim Ikhyun 
Published: June 2024

Abstract
Zirconium oxide (ZrO2) nanoparticles doped with silver (Ag) were synthesized utilizing Vitis vinifera leaf extract, offering a non-toxic and cost-effective production method. These nanoparticles were evaluated for their photocatalytic activity against both cationic (CR, EY, MO) and anionic (CV, MG, MB) dyes, alongside electrochemical impedance spectroscopy studies. The incorporation of silver into ZrO2 aimed to enhance the photocatalytic efficiency, particularly under visible light activation, for the significant removal of toxic contaminants. Analysis employing UV-vis spectroscopy and a pseudo-first-order kinetics model revealed that sunlight exposure notably improved dye degradation. Various techniques were employed to assess the physicochemical characteristics, indicating the reduction process in the chemical reaction and confirming nanoparticle formation through chemical bonding, as evidenced by peaks in the IR spectrum ranging from 450 to 660 cm−1. Furthermore, analysis of the UV–vis spectrum revealed bandgaps of 5.1 eV and 4.56 eV, confirming tetragonal and cubic crystal structures with crystalline sizes of approximately 15.7 nm and 17 nm for ZrO2 and Ag–ZrO2 nanoparticles, respectively. Electrochemical impedance spectra demonstrated that the addition of Ag to Zr notably improved charge transfer and electron separation processes.
THE USE OF DIGITAL COMPUTER TECHNOLOGIES IN THE FUTURE PROFESSIONAL ACTIVITIES OF STUDENTS
Authors: Карева Г.В. 
Published: June 2024

Подготовка студентов к использованию компьютерных и цифровых технологий в будущей профессиональной деятельности становится необходимым компонентом их образования. Между тем осуществляемая в вузах подготовка зачастую недостаточно основательна, что приводит к разрыву между требованиями к уровню владения специалистами компьютерными технологиями и уровнем готовности выпускников вузов к их использованию в будущей профессиональной деятельности. Для успешного внедрения цифровых компьютерных технологий в сферу образования необходимо уделить внимание комплексному решению проблем, включающему в себя как психологические, педагогические, методические, так и технические аспекты. Цель данного исследования – разработка системы, способствующей развитию у студентов навыков использования компьютерных технологий в их будущей профессиональной деятельности, определение педагогических и методических условий формирования у студентов навыков работы с компьютерными технологиями и разработка на этой основе соответствующего образовательного контента, программ, системы учебных занятий и методического обеспечения. Для оценки эффективности разработанной нами системы проводилась опытно-экспериментальная работа по апробации курса «Компьютерные технологии» с последующей статистической обработкой данных и их сравнительным анализом.
Preparing students to use computer and digital technologies in their future professional activities is becoming an essential component of their education. Meanwhile, the training provided at universities is oft en not sufficiently thorough, which leads to a gap between the requirements for the level of proficiency in computer technologies and the level of readiness of university graduates to use them in their future professional activities. For the successful implementation of digital computer technologies in the field of education, it is necessary to pay attention to a comprehensive solution of problems, including both psychological, pedagogical, methodological, and technical aspects. The purpose of this study is to develop a system that promotes the development of students’ skills in using computer technology in their future professional activities, to determine the pedagogical and methodological conditions for the formation of students’ skills in working with computer technology and the development of appropriate educational content, programs, a system of training sessions and methodological support on this basis. To assess the effectiveness of the system developed by us, experimental work was carried out on the approbation of the course “Computer Technology” with subsequent statistical processing of data and their comparative analysis. To assess the effectiveness of the developed system, experimental work was carried out on testing the course “Computer Technologies” with subsequent statistical processing and comparative analysis of the data obtained.
ГЕЙМИФИКАЦИЯ КАК СПОСОБ ОРГАНИЗАЦИИ ОБУЧЕНИЯ ИНОСТРАННОМУ ЯЗЫКУ В ВЫСШЕЙ ШКОЛЕ
Authors: Protsenko E.A. , Goltsova T.A. 
Published: June 2024

The article addresses the problem of gamification advent, illustrated by the example of computer educational games, for foreign language teaching in higher education institutions. The purpose of the article is to present the possibilities of applying computer games in a non-linguistic educational organization of higher education. The authors describe the gamification of teaching process as a technology that positively affects the development of foreign language communicative competence of students. The article reveals the advantages and problems of implementing the considered approach to educational process, both on the part of the teacher and on the part of the students. The authors describe their own experience of using computer games in English classes, demonstrate the advantages of some game templates for language skill training.
Проблема использования геймификации для обучения иностранному языку в высших образовательных учреждениях рассматривается на примере компьютерных обучающих игр. Цель статьи – представить возможности использования электронных игр в условиях неязыковой образовательной организации высшего образования. Геймификация обучения описывается авторами как технология, применение которой положительно влияет на развитие иноязычной коммуникативной компетенции обучающихся. В статье раскрываются достоинства и проблемы реализации рассматриваемого подхода к учебному процессу как со стороны преподавателя, так и со стороны обучающихся. Авторами описывается собственный опыт применения электронных обучающих игр на занятиях по английскому языку, демонстрируются преимущества применения отдельных игровых оболочек для формирования языковых навыков.
THE ROLE OF GAMIFICATION IN THE SYSTEM OF CORPORATE PERSONNEL TRAINING
Authors: Трифонов И.А. , Ядров К.П. 
Published: June 2024

В статье рассматривается роль геймификации в системе внутрикорпоративной подготовки кадров. Рассмотрено современное состояние систем корпоративной подготовки кадров и выделены ключевые проблемы. Рассмотрена концепция геймификации внутрикорпоративного обучения. Проведён анализ наиболее популярных исследований в сфере геймификации внутрикорпоративного обучения. Сделаны выводы о степени разработанности данной тематики в научном сообществе и потенциале геймификации для улучшения систем внутрикорпоративной подготовки кадров.
The article examines the role of gamification in the system of corporate personnel training. An analysis of the current state of the internal corporate personnel training system shows that the existing corporate training systems are often not adaptive, personalized or conducive to the implementation of knowledge. Due to the lack of structure and low motivation employees often lose interest in additional training. One of the innovative approaches that is being actively considered in this context is gamification. The article presents an analysis of the most popular studies in the field of gamification of corporate training, considers the key principles and basic elements of gamification. The authors highlight the potential of gamification elements such as challenges and storytelling, and shows a significant increase in employee satisfaction with corporate learning outcomes. At the same time, such gamification elements as clear objectives and feedback do not significantly affect the employee satisfaction. This fact may represent a new aspect in studying an impact of specific elements of gamification on employee satisfaction with corporate learning for effective development of educational strategies for corporate personnel training systems.
PROBLEMS AND PROSPECTS FOR THE IMPLEMENTATION OF PEDAGOGICAL CORRECTION OF GIFTED CHILDREN AT SECONDARY SCHOOL
Authors: Юдина Е.И. , Головятенко Т.А. , Зеленина Н.М. , Пашков В.М. 
Published: June 2024

В статье поставлена и проанализирована проблема отсутствия в практике общеобразовательных школ адресной работы по педагогической коррекции одаренных детей, рассмотрены ее причины. Даны понятия педагогической коррекции, категорий и содержания каждого из видов детской одаренности, группы риска; очерчены типичные личностные особенности одаренных учащихся как представителей группы риска. В качестве перспективных средств оптимизации педагогической коррекции одаренных детей как части единого образовательного процесса школы предложены повышение квалификации членов педагогического коллектива, накопление опыта работы с одаренными учащимися, использование резервов внеурочной деятельности. Охарактеризованы интерактивные инновационные формы проведения коррекционных занятий и образцы творческих заданий для одаренных учащихся в технологиях ускорения, углубления, обогащения, проблематизации.
The article poses and analyzes the problem of the lack of targeted work on pedagogical correction of gifted children in the practice of secondary schools and considers the reasons for this. The concepts of pedagogical correction, categories and content of each type of children’s giftedness, risk group are given. Typical personal characteristics of gifted students as representatives of a risk group are outlined. The article proposes the following promising means of optimizing the pedagogical correction of gifted children: 1) advanced training of teaching staff, 2) accumulation of experience in working with gifted children, 3) the use of reserves of extracurricular activities. The article also characterizes interactive innovative forms of conducting correctional classes and samples of creative tasks for gifted children with the use of such technologies as acceleration, deepening, enriching, and problematizing.
Characteristics and Functions of Infection-enhancing Antibodies to the N-terminal Domain of SARS-CoV-2
Authors: Connor Ruth , Sakharkar Mrunal , Rappazzo Garrett , Kaku Chengzi , Curtis Nicholas , Shin Seungmin , Wieland-Alter Wendy , Wentworth Jordan , Mielcarz Daniel , Weiner Joshua , Ackerman Margaret , Walker Laura , Lee Jiwon , Wright Peter 
Published: June 2024

Background: Fcγ-receptor (FcγR)-independent enhancement of SARS-CoV-2 infection mediated by N-terminal domain (NTD)-binding monoclonal antibodies (mAbs) has been observed in vitro, but the functional significance of these antibodies in vivo is less clear.
Methods: We characterized 1,213 SARS-CoV-2 spike (S)-binding mAbs derived from COVID-19 convalescent patients for binding specificity to the SARS-CoV-2 S protein, VH germ-line usage, and affinity maturation. Infection enhancement in a vesicular stomatitis virus (VSV)-SARS-CoV-2 S pseudovirus (PV) assay was characterized in respiratory and intestinal epithelial cell lines, and against SARS-CoV-2 variants of concern (VOC). Proteomic deconvolution of the serum antibody repertoire was used to determine functional attributes of secreted NTD-binding mAbs.
Results: We identified 72/1213 (5.9%) mAbs that enhanced SARS-CoV-2 infection in a PV assay. The majority (68%) of these mAbs recognized the NTD, were identified in patients with mild and severe disease, and persisted for at least 5 months post-infection. Infection enhancement by NTD-binding mAbs was not observed in intestinal and respiratory epithelial cell lines and was diminished or lost against SARS-CoV-2 VOC. Proteomic deconvolution of the serum antibody repertoire from 2 of the convalescent patients identified, for the first time, NTD-binding, infection-enhancing mAbs among the circulating immunoglobulins directly isolated from serum. Functional analysis of these mAbs demonstrated robust activation of FcγRIIIa associated with antibody binding to recombinant S proteins.
Conclusions: Functionally active NTD-specific mAbs arise frequently during natural infection and can last as major serum clonotypes during convalescence. These antibodies display functional attributes that include FcγR activation, and may be selected against by mutations in NTD associated with SARS-CoV-2 VOC.
DETERMINANTS OF PARTICIPATION SURVIVORS COVID-19 AMONG ≥45 YEARS OLD TO COVID-19 THIRD DOSE VACCINATION
Authors: Wahidah Putri Djamilah , Wardani Hartati Eko , Alma Lucky Radita , Gayatri Rara Warih 
Published: June 2024

Background: Booster vaccinations are a way to keep the body protected against COVID-19. Mojolangu Health Center is one of the densely populated areas which is part of the Lowokwaru sub-district and borders the Belimbing sub-district; the two sub-districts are ranked 2nd and 1st with the highest CFR (Case Fatality Rate) in Malang City. Therefore, examining public perceptions of vaccination to evaluate immunization programs and raise performance goals is essential. Purpose: To determine the relationship between the Health Belief Model components (perceived susceptibility, severity, benefits, barrier, and cues to action) and the participation of COVID-19 booster vaccination in survivors of COVID-19 aged ≥45 years. Conducted from April to November 2022, this research was located in the working area of Mojolangu Health Center (Mojolangu, Tunjungsekar, Tunggulwulung, and Tasikmadu village). Methods: This quantitative research used a case-control design study. This research sample comprised 82 people, selected using the purposive sampling technique with a 1:1 ratio for case and control. Data analysis was done using the Chi-Square test and Binary Logistics Regression tests. Results: The respondents were dominated by the middle age group (45-59 years), primarily entrepreneurs with a monthly income of more than IDR 3.5 million and domiciled in Mojolangu village. The perceived benefits variable showed p=0.04 (aOR=2.67; 95% CI=1.03-6.91) and perceived barriers p=0.01 (aOR=3.60; 95% CI=1.39-9.28), while perceived vulnerability p=1.00 (cOR=1.00; 95% CI= 0.32 – 3.16), perception of cues to act p= 0.18 (cOR= 1.82; 95% CI= 0.75 - 4.40). Conclusion: Factors related to booster vaccination participation are perceived benefits and barriers.
Clinical Outcomes Following Operative and Nonoperative Management of Odontoid Fractures Among Elderly Individuals with Dementia
Authors: Schoenfeld Andrew J. , Xiang Lingwei , Adler Rachel R. , Schoenfeld Alyssa L. , Kang James D. , Weissman Joel S. 
Published: June 2024

Background:
The incidence of odontoid fractures among the elderly population has been increasing in recent years. Elderly individuals with dementia may be at increased risk for inferior outcomes following such fractures. Although surgical intervention has been maintained to optimize survival and recovery, it is unclear if this benefit extends to patients with dementia. We hypothesized that patients with dementia who were treated operatively for odontoid fractures would experience improved survival and lower rates of hospice admission but higher rates of delirium and of intensive interventions.

Methods:
We used Medicare claims data (2017 to 2018) to identify community-dwelling individuals with dementia who sustained type-II odontoid fractures. We considered treatment strategy (operative or nonoperative) as the primary predictor and survival as the primary outcome. The secondary outcomes consisted of post-treatment delirium, hospice admission, post-treatment intensive intervention, and post-discharge admission to a nursing home or a skilled nursing facility. In all models, we controlled for age, biological sex, race, Elixhauser Comorbidity Index, Frailty Index, admission source, treating hospital, and dual eligibility. Adjusted analyses for survival were conducted using Cox proportional hazards regression. Adjusted analyses for secondary outcomes were performed using generalized estimating equations. To address confounding by indication, we performed confirmatory analyses using inverse probability of treatment weighting.

Results:
In this study, we included 1,030 patients. The median age of the cohort was 86.5 years (interquartile range, 80.9 to 90.8 years), 60.7% of the patients were female, and 90% of the patients were White. A surgical procedure was performed in 19.8% of the cohort. Following an adjusted analysis, patients treated surgically had a 28% lower hazard of mortality (hazard ratio, 0.72 [95% confidence interval (CI), 0.53 to 0.98]), but higher odds of delirium (odds ratio, 1.64 [95% CI, 1.10 to 2.44]). These findings were preserved in the inverse probability weighted analysis.

Conclusions:
We found that, among individuals with dementia who sustain a type-II odontoid fracture, surgical intervention may confer a survival benefit. A surgical procedure may be an appropriate treatment strategy for individuals with dementia whose life-care goals include life prolongation and maximizing quality of life in the short term following an injury.

Level of Evidence:
Therapeutic Level III. See Instructions for Authors for a complete description of levels of evidence.