bluuebunny/crossref_metadata_2025_split huggingface dataset:
Persistent orofacial muscle pain
Authors: Benoliel R , Svensson P , Heir GM , Sirois D , Zakrzewska J , Oke‐Nwosu J , Torres SR , Greenberg MS , Klasser GD , Katz J , Eliav E 
Published: March 2011

Oral Diseases (2011) 17 (Suppl. 1), 23–41The pathophysiology of persistent orofacial myalgia has been the centre of much controversy. In this article we suggest a novel descriptive term; ‘persistent orofacial muscle pain’ (POMP) and review current evidence that supports the hypothesis that the induction of POMP involves the interplay between a peripheral nociceptive source in muscle, a faulty central nervous system component and decreased coping ability. In this context it is widely accepted that a complex interaction of variable intrinsic and extrinsic factors act to induce POMP and dysfunction.
A systematic review of medical interventions for oral submucous fibrosis and future research opportunities
Authors: Kerr AR , Warnakulasuriya S , Mighell AJ , Dietrich T , Nasser M , Rimal J , Jalil A , Bornstein MM , Nagao T , Fortune F , Hazarey VH , Reichart PA , Silverman S , Johnson NW 
Published: March 2011

Oral Diseases (2011) 17 (Suppl. 1), 42–57Oral submucous fibrosis (OSF) is a chronic, insidious disease caused by areca nut use, and is associated with both significant morbidity (including pain and reduced oral opening) and an increased risk for malignancy. This systematic review explored and updated the current medical (i.e., non‐surgical) interventions available for the management of OSF. Of the 27 published medical interventions, there were four randomized controlled trials. The overall quality of these randomized controlled studies was assessed using the GRADE approach and significant limitations that challenged the conclusions were found. However, this review was valuable in terms of identifying opportunities to provide recommendations for future research, in terms of the populations to research, the types of interventions needed, the types of outcomes to be measured, the study designs needed, and the infrastructure required to conduct studies. The next step is to initiate a pathway for a low‐cost research plan leading to the development of a brief protocol for future clinical trials in this field, with an emphasis on conducting studies in regions of the world where OSF is prevalent.
An international survey of oral medicine practice: Proceedings from the 5th World Workshop in Oral Medicine
Authors: Stoopler ET , Shirlaw P , Arvind M , Lo Russo L , Bez C , De Rossi S , Garfunkel AA , Gibson J , Liu H , Liu Q , Thongprasom K , Wang Q , Greenberg MS , Brennan MT 
Published: March 2011

Oral Diseases (2011) 17 (Suppl. 1), 99–104Objectives:  (i) To define the current state of oral medicine clinical practice internationally, and (ii) to make recommendations for future modeling of the practice of oral medicine.Materials and methods:  A survey was designed by an international panel of oral medicine experts to assess the current state of oral medicine practice internationally. The survey was sent to oral medicine experts across the world, and responses were electronically stored and analyzed using descriptive statistics.Results:  Two hundred respondents completed the survey representing 40 countries from six continents. The two most common settings for an oral medicine practice were in a hospital and a dental school. More than 88% of respondents considered management of oral mucosal disease, salivary dysfunction, oral manifestations of systemic diseases, and facial pain in the definition of oral medicine.Conclusions:  (i) Oral medicine clinicians diagnose and manage a wide variety of orofacial conditions; (ii) There are significant differences in the definition of oral medicine clinical practice from country to country; (iii) India has the largest expansion of oral medicine services as defined by escalating numbers of clinicians within the specialty as compared with other countries; (iv) oral medicine practitioners have a wide range of professional responsibilities.
Fatty acid composition of ruminal bacteria and protozoa, and effect of defaunation on fatty acid profile in the rumen with special reference to conjugated linoleic acid in cattle
Authors: SULTANA Halima , MIYAZAWA Kenji , KANDA Shuhei , ITABASHI Hisao 
Published: March 2011

ABSTRACTObjectives of this study were to compare fatty acid (FA) composition of ruminal bacterial (B) and protozoal (P) cells, and to investigate effect of protozoa on FA profile in the rumen of cattle. Three cows were used to prepare ruminal B and P cells. Four faunated and three defaunated cattle (half‐siblings) were used to study effect of protozoa on ruminal FA profile. Proportions of C16:0 and C18:0 in total fatty acids in B cells were 20.7% and 37.4%, whereas those in P cells were 33.4% and 11.6%, respectively. Proportions of trans‐vaccenic acid (VA) and cis‐9, trans‐11 conjugated linoleic acid (CLA) in B cells were 3.9% and 1.0%, and those in P cells were 5.5% and 1.6%, respectively, being higher in P cells. Proportions of C18:1, C18:2 and C18:3 in P cells were two to three times higher than in B cells. Proportions of unsaturated fatty acids, VA and CLA in B cells of faunated cattle were higher than those of defaunated. VA and CLA in the ruminal fluid of faunated were also 1.6 to 2.5 times higher than those of defaunated. This tendency was similar for cell‐free fraction of ruminal fluid. These results indicate that protozoa contribute greatly in VA and CLA production in the rumen.
Interaction between very‐KIND Ras guanine exchange factor and microtubule‐associated protein 2, and its role in dendrite growth – structure and function of the second kinase noncatalytic C‐lobe domain
Authors: Huang Jinhong , Furuya Asako , Hayashi Kanehiro , Furuichi Teiichi 
Published: March 2011

The kinase noncatalytic C‐lobe domain (KIND) is a putative protein–protein interaction module. Four KIND‐containing proteins, Spir‐2 (actin‐nuclear factor), PTPN13 (protein tyrosine phosphatase), FRMPD2 (scaffold protein) and very‐KIND (v‐KIND) (brain‐specific Ras guanine nucleotide exchange factor), have been identified to date. Uniquely, v‐KIND has two KINDs (i.e. KIND1 and KIND2), whereas the other three proteins have only one. The functional role of KIND, however, remains unclear. We previously demonstrated that v‐KIND interacts with the high‐molecular weight microtubule‐associated protein 2 (MAP2), a dendritic microtubule‐associated protein, leading to negative regulation of neuronal dendrite growth. In the present study, we analyzed the structure–function relationships of the v‐KIND–MAP2 interaction by generating a series of mutant constructs. The interaction with endogenous MAP2 in mouse cerebellar granule cells was specific to v‐KIND KIND2, but not KIND1, and was not observed for the KINDs from other KIND‐containing proteins. The binding core modules critical for the v‐KIND–MAP2 interaction were defined within 32 residues of the mouse v‐KIND KIND2 and 43 residues of the mouse MAP2 central domain. Three Leu residues at amino acid positions 461, 474 and 477 in the MAP2‐binding core module of KIND2 contributed to the interaction. The MAP2‐binding core module itself promoted dendrite branching as a dominant‐negative regulator of v‐KIND in hippocampal neurons. The results reported in the present study demonstrate the structural and functional determinant underlying the v‐KIND–MAP2 interaction that controls dendrite arborization patterns.Structured digital abstract
vKIND‐KIND2
binds to Map2 by pull down (View interaction)
Map2
physically interacts with vKIND‐KIND2 by pull down (View interaction 1, 2, 3, 4, 5)
Map2
physically interacts with vKIND by pull down (View interaction)
Map2
physically interacts with vKIND‐KIND2 by anti bait coimmunoprecipitation (View interaction)
vKIND‐KIND2
physically interacts with Map2 by pull down (View interaction)
Early Regeneration of Tropical Dry Forest from Abandoned Pastures: Contrasting Chronosequence and Dynamic Approaches
Authors: Maza‐Villalobos Susana , Balvanera Patricia , Martínez‐Ramos Miguel 
Published: March 2011

ABSTRACTOld field secondary succession of tropical dry forests (TDFs) is poorly understood, particularly regarding the dynamics of seedlings, saplings, and sprouts (regenerative communities). We used chronosequence and dynamic approaches to: (1) document successional trajectories of regenerative communities during the first dozen years of regeneration in abandoned pastures at Chamela, Mexico; (2) test the usefulness of chronosequences to predict the dynamics of regenerative communities along time; and (3) assess the influence of surrounding forest matrix, stand density, and understory light availability (in the rainy season) as driving factors of such dynamics. More than 1000 plants and 95 species of shrubs and trees 10–100 cm tall were monitored between 2004 and 2007 in nine abandoned pastures (0–12 yr since abandonment) and two old‐growth forest (OGF) sites; gain and loss rates of plants, species, and plant cover were obtained. Chronosequence predicted a rapid and asymptotic increase of plant density, species density, and plant cover toward the OGF values. Such prediction did not match with dynamic data that showed negative or neutral net community rates of change, independently of fallow age. Recruitment and species gain rates increased with the amount surrounding forest matrix. No other effect of the explored factors was detected. Strong rainfall shortenings could be responsible for the high loss and low gain rates of plants and species recorded in most sites. We highlight the critical role of supra‐annual rainfall variability on the dynamics of TDF regenerative communities and the poor predictive value of chronosequences in forest systems subjected to strong environmental temporal variation.Abstract in Spanish is available athttp://www.blackwell‐synergy.com/loi/btp.
Incidental findings from lung CT scans: Implications for research
Authors: Aldington Sarah , Shirtcliffe Philippa , Nowitz Mike , Kingzett‐Taylor Andrew , Tweed Mike , Weatherall Mark , Soriano Joan B , Beasley Richard 
Published: March 2011

AbstractIntroduction: We aimed to evaluate the number and nature of incidental findings in CT chest scans in the context of a study of the pulmonary effects of cannabis.Methods: Three hundred fifty‐seven participants were recruited: 78 cannabis‐only smokers, 92 tobacco‐only smokers, 106 smokers of cannabis and tobacco and 81 never smokers. All participants underwent a high‐resolution CT scan of their thorax. Two radiologists read the scans. Associations between abnormalities and age, sex, tobacco and cannabis smoking status were expressed as odds ratios (OR) with 95% confidence interval.Results: Seventy‐six findings requiring referral or further investigations were found in 71/357 (19.9%) of participants. In multivariate analyses, only older age, OR (per decade) 2.1 (1.4 to 3.0), was associated with a respiratory abnormality on the CT scan. A total of 37/76 (48.7%) of the abnormalities detected were extra‐pulmonary, with findings observed across a wide range of organ systems. Only older age, OR (per decade) 1.7 (1.2 to 2.5), was associated with a non‐respiratory abnormality.Conclusion: The common occurrence of abnormal findings requiring referral or further investigations raises practical, ethical and medico‐legal issues which need to be carefully considered in research programmes utilising chest CT scanning.
Range and demographics of radiolucent jaw lesions in a New Zealand population
Authors: Becconsall‐Ryan Karyn , Love Robert M 
Published: March 2011

AbstractAim: To determine the range and demographic features of radiolucent jaw lesions in a New Zealand population.Methods: Histopathology reports from the University of Otago School of Dentistry over a 20‐year period were reviewed to identify radiolucent jaw lesions. Reporting characteristics where standardised over the time period. There were no clinical exclusive criteria and the samples represented a wide range of clinical presentation and treatment history from multiple providers. Data were analysed using SPSS.Results: A total of 17 038 specimens were submitted to the oral pathology diagnostic service of which there were 4983 radiolucent lesions that fulfilled the criteria to be included in the study. The full range of pathology was detected over the twenty‐year period and the study showed that the five most common radiolucent jaw lesions were the periapical granuloma, radicular cyst, dentigerous cyst, hyperplastic dental follicle and odontogenic keratocyst, which they accounted for 79.6% of all radiolucent jaw lesions.Conclusion: The range and demographic features of radiolucent jaw lesions in a New Zealand population was similar to international trends.
MRI findings of cerebral cryptococcosis in immunocompetent patients
Authors: Chen Shaoqiong , Chen Xiaohong , Zhang Zhigang , Quan Li , Kuang Sichi , Luo Xiao 
Published: March 2011

SummaryWorldwide, cerebral cryptococcal infections caused by cryptococcus neoformans are mostly found in immunocompromised patients, but less found in immunocompetent patients with fewer related imaging reports in literatures. This pictorial essay describes some important MR imaging features in arriving at diagnosis for cerebral cryptococcosis in immunocompetent patients by way of five illustrative cases with intact MRI data.
Antihyperalgesic activity of verbascoside in two models of neuropathic pain
Authors: Isacchi Benedetta , Iacopi Romina , Bergonzi Maria Camilla , Ghelardini Carla , Galeotti Nicoletta , Norcini Monica , Vivoli Elisa , Vincieri Franco Francesco , Bilia Anna Rita 
Published: March 2011

Abstract

Objectives
This study reports on the rapid isolation of verbascoside from Lippia citriodora H.B.K. (Verbenaceae), an inexpensive and widespread source, and the evaluation of its antihyperalgesic activity.

Methods
Isolation of verbascoside was achieved by size exclusion chromatography with Sephadex LH-20 eluting with 50% EtOH, which is proposed as a fast and efficient method of separation.

Key findings
The antihyperalgesic activity of verbascoside was tested by in-vivo assay using the paw-pressure test in two animal models of neuropathic pain: a peripheral mononeuropathy produced either by a chronic constriction injury of the sciatic nerve (CCI) or by an intra-articular injection of sodium monoiodoacetate (MIA).

Conclusions
Verbascoside administered intraperitoneally at a dose of 100 mg/kg reverted the mechanical hyperalgesia in both CCI and MIA treated rats, as evaluated in the paw-pressure test. Verbascoside was also effective against mechanical hyperalgesia after oral administration at doses of 300 and 600 mg/kg.
Fluoroquinolone and Quinazolinedione Activities against Wild-Type and Gyrase Mutant Strains of Mycobacterium smegmatis
Authors: Malik Muhammad , Marks Kevin R. , Mustaev Arkady , Zhao Xilin , Chavda Kalyan , Kerns Robert J. , Drlica Karl 
Published: March 2011

ABSTRACT

Quinazolinediones (diones) are fluoroquinolone-like inhibitors of bacterial gyrase and DNA topoisomerase IV. To assess activity against mycobacteria, C-8-methoxy dione derivatives were compared with cognate fluoroquinolones by using cultured
Mycobacterium smegmatis
. Diones exhibited higher MIC values than fluoroquinolones; however, MICs for fluoroquinolone-resistant
gyrA
mutants, normalized to the MIC for wild-type cells, were lower. Addition of a 3-amino group to the 2,4-dione core increased relative activity against mutants, while alteration of the 8-methoxy group to a methyl or of the 2,4-dione core to a 1,3-dione core lowered activity against mutants. A GyrA G89C bacterial variant was strikingly susceptible to most of the diones tested; in contrast, low susceptibility to fluoroquinolones was observed. Many of the bacteriostatic differences between diones and fluoroquinolones were explained by interactions at the N terminus of GyrA helix IV revealed by recently published X-ray structures of drug-topoisomerase-DNA complexes. When lethal activity was normalized to the MIC in order to minimize the effects of drug uptake, efflux, and ternary complex formation, a 3-amino-2,4-dione exhibited killing activity comparable to that of a cognate fluoroquinolone. Surprisingly, the lethal activity of the dione was inhibited less by chloramphenicol than that of the cognate fluoroquinolone. This observation adds the 2,4-dione structural motif to the list of structural features known to impart lethality to fluoroquinolone-like compounds in the absence of protein synthesis, a phenomenon that is not explained by X-ray structures of drug-enzyme-DNA complexes.
Clonal Spread of Levofloxacin-Resistant Streptococcus pneumoniae Invasive Isolates in Madrid, Spain, 2007 to 2009
Authors: Rodríguez-Avial Iciar , Ramos Belén , Ríos Esther , Cercenado Emilia , Ordobás María , Sanz Juan Carlos 
Published: March 2011

ABSTRACT

Among 1,349
Streptococcus pneumoniae
invasive isolates, 45 (3.3%) were levofloxacin resistant. Serotype distribution was as follows: 8 (
n
= 32 isolates), 19A (
n
= 4 isolates), 7F (
n
= 3 isolates), 9V (
n
= 2 isolates), 10A (
n
= 1 isolate), 19F (
n
= 1 isolate), 6B (
n
= 1 isolate), and nontypeable (
n
= 1 isolate). Levofloxacin-resistant isolates had dual mutations in the
gyrA
and
parC
genes. Serotype 8 strains corresponded to a capsular switching of the Sweden
15A
-25 clone. Levofloxacin resistance was also detected among multiresistant (ST276
19A
, Spain
9V
-ST156, ST88
19F
, and ST1542
6B
) and among usually antibiotic-susceptible (Netherlands
7F
-ST191, ST1201
19A
, and ST2639
10A
) clones.
Effect of Nutritional Status on Response to Treatment with Artemisinin-Based Combination Therapy in Young Ugandan Children with Malaria
Authors: Verret Wendy J. , Arinaitwe Emmanuel , Wanzira Humphrey , Bigira Victor , Kakuru Abel , Kamya Moses , Tappero Jordan W. , Sandison Taylor , Dorsey Grant 
Published: March 2011

ABSTRACT

The relationship between malnutrition and malaria in young children is under debate, and no studies evaluating the association between malnutrition and response to artemisinin-based combination therapies (ACTs) have been published. We evaluated the association between malnutrition and response to antimalarial therapy in Ugandan children treated with ACTs for repeated episodes of malaria. Children aged 4 to 12 months diagnosed with uncomplicated malaria were randomized to dihydroartemisinin-piperaquine (DP) or artemether-lumefantrine (AL) and followed for up to 2 years. All HIV-exposed and HIV-infected children received trimethoprim-sulfamethoxazole prophylaxis (TS). The primary exposure variables included height-for-age and weight-for-age
z
scores. Outcomes included parasite clearance at days 2 and 3 and risk of recurrent parasitemia after 42 days of follow-up. Two hundred ninety-two children were randomized to DP or AL, resulting in 2,013 malaria treatments. Fewer than 1% of patients had a positive blood smear by day 3 (DP, 0.2%; AL, 0.6% [
P
= 0.18]). There was no significant association between height-for-age or weight-for-age
z
scores and a positive blood smear 2 days following treatment. For children treated with DP but not on TS, decreasing height-for-age
z
scores of <−1 were associated with a higher risk of recurrent parasitemia than a height-for-age
z
score of >0 (hazard ratio [HR] for height-for-age
z
score of <−1 and ≥−2 = 2.89 [
P
= 0.039]; HR for height-for-age
z
score of <−2 = 3.18 [
P
= 0.022]). DP and AL are effective antimalarial therapies in chronically malnourished children in a high-transmission setting. However, children with mild to moderate chronic malnutrition not taking TS are at higher risk for recurrent parasitemia and may be considered a target for chemoprevention.
Association between Levels of C-Reactive Protein and Leukocytes and Cancer: Three Repeated Measurements in the Swedish AMORIS Study
Authors: Van Hemelrijck Mieke , Holmberg Lars , Garmo Hans , Hammar Niklas , Walldius Göran , Binda Elisa , Lambe Mats , Jungner Ingmar 
Published: March 2011

AbstractObjective: To study levels of C-reactive protein (CRP) and leukocytes, as inflammatory markers, in the context of cancer risk.Methods: From the Apolipoprotein MOrtality RISk (AMORIS) study, we selected 102,749 persons with one measurement and 9,273 persons with three repeated measurements of CRP and leukocytes. Multivariate Cox proportional hazards regression was applied to categories of CRP (&lt;10, 10–15, 15–25, 25–50, &gt;50 g/L) and quartiles of leukocytes. An inflammation-based predictive score (IPS) indicated whether someone had CRP levels of more than 10 mg/L combined with leukocytes of more than 10 × 109/L. Reverse causality was assessed by excluding those with less than 3, 5, or 7 years of follow-up. To analyze repeated measurements of CRP and leukocytes, the repeated IPS (IPSr) was calculated by adding the IPS of each measurement.Results: In the cohort with one measurement, there was a positive trend between CRP and risk of developing cancer, with the lowest category being the 0.99 (0.92–1.06), 1.28 (1.11–1.47), 1.27 (1.09–1.49), and 1.22 (1.01–1.48) for the second to fifth categories, respectively. This association disappeared when excluding those with follow-up of less than 3, 5, or 7 years. The association between leukocytes and cancer was slightly stronger. In the cohort with repeated measurements, the IPSr was strongly associated with cancer risk: 1.87 (1.33–2.63), 1.51 (0.56–4.06), and 4.46 (1.43–13.87) for IPSr = 1, 2, and 3 compared with IPSr = 0. The association remained after excluding those with follow-up of less than 1 year.Conclusions and Impact: Our large, prospective cohort study adds evidence for a link between inflammatory markers and cancer risk by using repeated measurements and ascertaining reverse causality. Cancer Epidemiol Biomarkers Prev; 20(3); 428–37. ©2011 AACR.
Antitumor Activity of the Hsp90 Inhibitor IPI-504 in HER2-Positive Trastuzumab-Resistant Breast Cancer
Authors: Scaltriti Maurizio , Serra Violeta , Normant Emmanuel , Guzman Marta , Rodriguez Olga , Lim Alice R. , Slocum Kelly L. , West Kip A. , Rodriguez Varenka , Prudkin Ludmila , Jimenez José , Aura Claudia , Baselga José 
Published: March 2011

Abstract
Hsp90 facilitates the maturation and stability of numerous oncoproteins, including HER2. The aim of this study was to assess the antitumor activity of the Hsp90 inhibitor IPI-504 in trastuzumab-resistant, HER2-overexpressing breast cancer cells. Therapy with trastuzumab, IPI-504, and the combination of trastuzumab and IPI-504 was evaluated in trastuzumab-sensitive and trastuzumab-resistant cells. Inhibition of protein targets, cell proliferation, and tumor growth was assessed in vitro and in xenograft models. IPI-504 inhibited proliferation of both trastuzumab-sensitive and trastuzumab-resistant cells. Administration of IPI-504 markedly reduced total levels of HER2 and Akt, as well as phosphorylated Akt and mitogen-activated protein kinase (MAPK), to an equal extent in trastuzumab-sensitive and trastuzumab-resistant cells. IPI-504, used as single agent or in combination with trastuzumab, also inhibited in vivo the growth of both trastuzumab-sensitive and -resistant tumor xenografts. As a mechanism for the observed antitumor activity, IPI-504 resulted in a marked decrease in the levels of HER2, Akt, p-Akt, and p-MAPK in trastuzumab-resistant xenografts as early as 12 hours after a single dose of IPI-504. IPI-504–mediated Hsp90 inhibition may represent a novel therapeutic approach in trastuzumab refractory HER2-positive breast cancer. Mol Cancer Ther; 10(5); 817–24. ©2011 AACR.