bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparison of Composite Measure Methodologies for Rewarding Quality of Care
Authors: Eapen Zubin J. , Fonarow Gregg C. , Dai David , O'Brien Sean M. , Schwamm Lee H. , Cannon Christopher P. , Heidenreich Paul A. , Bhatt Deepak L. , Peterson Eric D. , Hernandez Adrian F. 
Published: October 2011

Background—
Composite indices of health care performance are an aggregation of underlying individual performance measures and are increasingly being used to rank hospitals. We sought to conduct an observational analysis to determine the influence of the opportunity-based and all-or-none composite performance measures on hospital rankings.

Methods and Results—

We examined 194 245 patients hospitalized with acute myocardial infarction between July 2006 and June 2009 from 334 hospitals participating in the Get With The Guidelines–Coronary Artery Disease (GWTG–CAD) quality improvement program. We analyzed hospital opportunity-based and all-or-none composite scores and 30-day risk-standardized all-cause mortality and readmission rates. We found that the median calculated opportunity-based score for these hospitals was 95.5 (interquartile range, 90.4, 98.0). The median all-or-none score was 88.9 (interquartile range, 79.7, 94.4). The 2 scoring methods were significantly correlated with one another (
r
=0.98,
P
<0.001). Rankings generated by the two methods were significantly correlated (
r
=0.93,
P
<0.001). The two methods had a modest correlation with the 30-day risk-standardized mortality rate (opportunity-based score:
r
=−0.25,
P
<0.001; all-or-none score:
r
=−0.24,
P
<0.001). Neither composite measure correlated with the 30-day risk-standardized readmission rate. Over time, the number of hospitals new to the top and bottom quintiles of hospital rankings diminished similarly for both composite measures. When including additional performance measures into the composite score, the two methods produced similar changes in hospital rankings.

Conclusions—
The opportunity-based and all-or-none coronary artery disease composite indices are highly correlated and yield similar ranking of the top and bottom quintiles of hospitals. The two methods provide similarly modest correlations with 30-day mortality, but not readmission.
Is Missing Orographic Gravity Wave Drag near 60°S the Cause of the Stratospheric Zonal Wind Biases in Chemistry–Climate Models?
Authors: McLandress Charles , Shepherd Theodore G. , Polavarapu Saroja , Beagley Stephen R. 
Published: October 2011

Abstract
Nearly all chemistry–climate models (CCMs) have a systematic bias of a delayed springtime breakdown of the Southern Hemisphere (SH) stratospheric polar vortex, implying insufficient stratospheric wave drag. In this study the Canadian Middle Atmosphere Model (CMAM) and the CMAM Data Assimilation System (CMAM-DAS) are used to investigate the cause of this bias. Zonal wind analysis increments from CMAM-DAS reveal systematic negative values in the stratosphere near 60°S in winter and early spring. These are interpreted as indicating a bias in the model physics, namely, missing gravity wave drag (GWD). The negative analysis increments remain at a nearly constant height during winter and descend as the vortex weakens, much like orographic GWD. This region is also where current orographic GWD parameterizations have a gap in wave drag, which is suggested to be unrealistic because of missing effects in those parameterizations. These findings motivate a pair of free-running CMAM simulations to assess the impact of extra orographic GWD at 60°S. The control simulation exhibits the cold-pole bias and delayed vortex breakdown seen in the CCMs. In the simulation with extra GWD, the cold-pole bias is significantly reduced and the vortex breaks down earlier. Changes in resolved wave drag in the stratosphere also occur in response to the extra GWD, which reduce stratospheric SH polar-cap temperature biases in late spring and early summer. Reducing the dynamical biases, however, results in degraded Antarctic column ozone. This suggests that CCMs that obtain realistic column ozone in the presence of an overly strong and persistent vortex may be doing so through compensating errors.
The Role of Sea Ice Thickness Distribution in the Arctic Sea Ice Potential Predictability: A Diagnostic Approach with a Coupled GCM
Authors: Chevallier Matthieu , Salas-Mélia David 
Published: October 2011

Abstract
The intrinsic seasonal predictability of Arctic sea ice is investigated in a 400-yr-long preindustrial simulation performed with the Centre National de Recherches Météorologiques Coupled Global Climate Model, version 3.3 (CNRM-CM3.3). The skill of several predictors of the pan-Arctic sea ice area was quantified: the sea ice area itself, the pan-Arctic sea ice volume, and some areal predictors built from the subgrid ice thickness distribution (ITD). Sea ice area provides a potential predictability of about 3 months, which is consistent with previous studies using model and observation data. Sea ice volume predictive skill for winter sea ice area prediction is weak. Nevertheless, there is a higher potential to predict the September ice area with the June volume anomaly than with the June area anomaly. Using ITD-based predictors, two “regimes” of predictability were highlighted. The first one, a “persistence regime,” applies to winter/early spring sea ice seasonal predictability. The winter sea ice cover can be predicted in late fall/early winter from the amount of young ice formed since the freeze-up onset in the margins. However, sea ice area itself is potentially the best predictor of winter sea ice area at seasonal time scales. The second regime is a “memory regime.” It applies to the predictability of summer sea ice area. An ice area anomaly in September is potentially predictable up to 6 months in advance, using the area covered by ice thicker than a critical thickness lying between 0.9 and 1.5 m. Results of this study are preliminary; however, they provide information for the design of future prediction systems and highlight the need for observations and a state-of-the-art sea ice model.
Performance-based tests in subjects with stroke: outcome scores, reliability and measurement errors
Authors: Faria Christina DCM , Teixeira-Salmela Luci F , Neto Mansueto Gomes , Rodrigues-de-Paula Fátima 
Published: October 2011

Objectives: To assess the intra- and inter-rater reliabilities and measurement errors of seven widely applied performance-based tests for stroke subjects (comfortable/maximal gait speeds and both stair ascending/descending cadences, as well as the Timed ‘Up and Go’ test) and to verify whether the use of different types of outcome scores (one trial, the means of two and three trials, and the best and the worst values of the three trials) affected the score values, as well as their reliability and measurement errors. Design: Intra- and inter-rater reliability study. Setting: Research laboratory. Subjects: Sixteen stroke subjects with a mean age of 52 ± 17.9 years. Main measures: Seven performance-based tests, over two sessions, seven days apart, evaluated by two independent examiners. A third examiner recorded all data. One-way ANOVAs, intra-class correlation coefficients (ICCs) and percentages of the standard errors of measurement (SEM%) were used for analyses. Results: For all tests, similar results were found for all types of outcome scores (0.01 ≤ F ≤ 0.56; 0.34 ≤ p ≤ 0.99). For instance, at the comfortable gait speed, the means (SD) values for the first trial, the means of two and three trials and the best and worst of three trials were, respectively, 1.04 (0.25), 1.04(0.24), 1.05 (0.24), 1.10 (0.26), 1.02 (0.24) seconds. Significant and adequate values of intra- (0.75 ≤ ICC ≤ 0.96; p ≤ 0.002) and inter-rater (0.75 ≤ ICC ≤ 0.97; p ≤ 0.001) reliabilities were found for all tests and outcome scores. Measurement errors were considered low (5.01 ≤ SEM% ≤14.78) and were also similar between all outcome scores. Conclusions: For the seven tests, only one trial was necessary to provide consistent and reliable results regarding the functional performances of stroke subjects.
Reflexive attentional orienting in migraineurs: The behavioral implications of hyperexcitable visual cortex
Authors: Mickleborough Marla JS , Hayward Jake , Chapman Christine , Chung Janelle , Handy Todd C 
Published: October 2011

Introduction: Although migraine is classified as a headache disorder, a key part of migraine pathophysiology is a heightened excitability of visual cortices in between headache events. The goal of our study was to examine the behavioral impact of this visuocortical hyperexcitability, in terms of its effect on reflexive visual attentional orienting. Methods and results: In Experiment 1, using a non-predictive spatial cuing task that relied on sensory-evoked responses in the visual cortex for triggering attentional orienting, we found that migraineurs had greater attentional enhancement of manual target responses, relative to non-migraine controls. In two control experiments we confirmed that this heightened attention effect in migraineurs is not due to exaggerated reflexive orienting responses in general, but rather, it appears to be specifically associated with sensory-evoked attentional triggers. Discussion: Taken together, this confirms that the functional consequences of hyperexcitable visual cortex in migraineurs are not just purely sensory in nature, but directly impact at least some forms of reflexive attention. This provides evidence of at least one cognitive implication of hyperexcitable visual cortical responses in migraineurs, namely heightened reflexive visual-spatial orienting specific to sudden-onset peripheral events.
A comparison of Stone Cone versus lidocaine jelly in the prevention of ureteral stone migration during ureteroscopic lithotripsy
Authors: Bastawisy Mohamed , Gameel Tarek , Radwan Mohamed , Ramadan Ahmed , Alkathiri Mutie , Omar Adel 
Published: October 2011

Background: Intracorporeal lithotripsy modalities and stone removal devices have been created to facilitate endoscopic management of ureteral stones. These devices, along with improved techniques, have resulted in stone-free rates greater than 95% with low morbidity. However, problems remain that preclude consistent 100% stone-free rates with endoscopic treatment of ureteral calculi. Retrograde migration during ureteroscopic procedures remains a significant problem. Objectives: The aim of this study was to compare the Stone Cone device and instillation of lubricating lidocaine jelly as two methods to prevent retrograde stone migration during ureteroscopic lithotripsy. Patients and methods: This study included patients suffering from ureteral stones that were treated with intracorporeal lithotripsy using the pneumatic Lithoclast. These patients were divided into two groups. In group I, the Stone Cone device was used, while in group II, lidocaine jelly 2% concentration was used. Results: This study included 40 patients with a mean age of 38.6 ± 9.3 years (20 patients in each group). There was no significant difference between the groups with regards to stone site, size or state of the upper urinary tract by excretory urography. The pneumatic Lithoclast allowed successful fragmentation of all calculi into small fragments. Upward stone migration did not occur in patients in the Stone Cone group, while in the lidocaine jelly group it occurred in three patients (15%). The operative time in the Stone Cone group ranged between 30 and 55 minutes (mean, 41.8 ± 5.3), while in the lidocaine jelly group it ranged between 40 and 71 minutes (mean, 51.4 ± 3.4), and this difference was statistically significant ( p < 0.05). Conclusion: The Stone Cone is safe and efficient in preventing proximal stone migration during ureteroscopic pneumatic lithotripsy. It maintained continuous ureteral access and demonstrated a statistically significant advantage over the lidocaine jelly in terms of proximal stone migration, operative time, and the need for auxiliary procedures.
VKORC1 and CYP2C9 genotype and patient characteristics explain a large proportion of the variability in warfarin dose requirement among children
Authors: Biss Tina T. , Avery Peter J. , Brandão Leonardo R. , Chalmers Elizabeth A. , Williams Michael D. , Grainger John D. , Leathart Julian B. S. , Hanley John P. , Daly Ann K. , Kamali Farhad 
Published: October 2011

Abstract
Although genetic and environmental factors explain approximately half of the interindividual variability in warfarin dose requirement in adults, there is limited information available in children. In a cross-sectional study of anticoagulated children from 5 tertiary care centers, 120 children with a stable warfarin dose were genotyped for VKORC1 (−1639G > A; rs9923231), CYP2C9 (*2 and *3 alleles; rs1799853 and rs1057910), and CYP4F2 (V433M; rs2108622) polymorphisms. Clinical and demographic features were recorded. Multiple regression analysis of the data showed that, although CYP4F2 made no contribution to the dose model, 72.4% of the variability in warfarin dose requirement is attributed to by patient height, genetic polymorphisms in VKORC1 and CYP2C9, and indication for warfarin. The recently published International Warfarin Pharmacogenetics Consortium pharmacogenetic-based warfarin dosing algorithm (based on data derived from anticoagulated adults) consistently overestimated warfarin dose for our cohort of children. A similar proportion of the interindividual variability in warfarin dose is explained by genetic factors in children compared with adult patients, although height is a greater predictor in children. A pharmacogenomic approach to warfarin dosing has the potential to improve the efficacy and safety of warfarin therapy in children. However, algorithms should be derived from data in children if their potential benefit is to be realized.
Body piercing and tattoos: a survey on young adults' knowledge of the risks and practices in body art
Authors: Quaranta Alessia , Napoli Christian , Fasano Fabrizio , Montagna Claudio , Caggiano Giuseppina , Montagna Maria Teresa 
Published: October 2011

Abstract

Background
The practice of tattooing and piercing has expanded in western society. In order to verify young adults' knowledge of the risk and practices related to body art, an investigation was conducted among freshmen of the University of Bari in the region of Apulia, Italy.

Methods
The study was carried out in the Academic Year 2009-2010 through an anonymous self-administered written questionnaire distributed to 1.656 freshmen enrolled in 17 Degree Courses.

Results
Of the 1.598 students included in the analysis, 78.3% believe it is risky to undergo piercing/tattoo practices. AIDS was indicated as a possible infection by 60.3% of freshmen, hepatitis C by 38.2%, tetanus by 34.3% and hepatitis B by 33.7% of the sample. 28.1% of freshmen were not aware that there are also non-infectious complications. 29% of the sample had at least one piercing or tattoo (this percentage does not include earlobe piercing in women). Of those with body art, the decision to undergo body art was made autonomously in 57.9% of the participants. 56.3% of freshmen undergoing body art had taken less than a month to decide. With regard to the reasons that led the sample to undergo body art, 28.4% were unable to explain it, 23.8% answered to improve their aesthetic aspect, 18.4% to distinguish themselves from others, 12.3% for fashion; 17.1% for other reasons. 25.4% of the sample declared that they had a piercing (79.8% female vs 20.2% male; ratio M/F 1:4.0). The average age for a first piercing was 15.3 years (range 10-27; SD ± 2.9). 9.6% of the sample declared that they have a tattoo (69.9% female vs 30.1% male; ratio M/F 1:2.3). The average age for a first tattoo was 17.5 years (range 10-26, SD ± 2.4).

Conclusions
Most of the freshmen knew about AIDS-related risks but not other potential risks. Body art is fairly common among young adults (especially women). The decision is often not shared with the family and is undertaken mostly without a specific reason or for the improvement of aesthetic aspect. Information about freshmen's knowledge, attitudes and practices could help in effective planning of health promotion strategies.
Beverage patterns and trends among school-aged children in the US, 1989-2008
Authors: Lasater Gentry , Piernas Carmen , Popkin Barry M 
Published: October 2011

Abstract

Background
High intake of sugar-sweetened beverages in childhood is linked to increased risk of obesity and type II diabetes later in life. Using three nationally representative surveys of dietary intake, we investigated beverage patterns and trends among US school-aged children from 1989/91 to 2007/08.

Methods
3, 583 participants ages 6-11 y old were included. We reported per capita trends in beverage consumption, percent consuming, and amount per consumer for the following categories of beverages: sugar-sweetened beverages (SSB), caloric nutritional beverages (CNB) and low calorie beverages (LCB). Statistically significant differences were tested using the Student's t test in Stata 11.

Results
While per capita kcal contribution from total beverages remained constant over the study period, per capita consumption of SSBs increased and CNBs decreased in similar magnitude. The substantial increase in consumption of certain SSBs, such as fruit drinks and soda, high fat high sugar milk, and sports drinks, coupled with the decrease in consumption of high fat low sugar milk was responsible for this shift. The percent consuming SSBs as well as the amount per consumer increased significantly over time. Per capita intake of total milk declined, but the caloric contribution from high fat high sugar milk increased substantially. Among ethnicities, important differences in consumption trends of certain SSBs and 100% juice indicate the complexity in determining strategies for children's beverage calorie reduction.

Conclusions
As upward trends of SSB consumption parallel increases in childhood obesity, educational and policy interventions should be considered.
Cut-off points of the visceral adiposity index (VAI) identifying a visceral adipose dysfunction associated with cardiometabolic risk in a Caucasian Sicilian population
Authors: Amato Marco C , Giordano Carla , Pitrone Maria , Galluzzo Aldo 
Published: October 2011

Abstract

Background
The Visceral Adiposity Index (VAI) is a sex-specific mathematical index, based on Waist Circumference (WC), Body Mass Index (BMI), triglycerides (TG) and HDL cholesterol (HDL) levels, indirectly expressing visceral adipose function and insulin sensitivity. Our aim was to find the optimal cut-off points of VAI identifying a visceral adipose dysfunction (VAD) associated with cardiometabolic risk in a Caucasian Sicilian population.

Methods
Medical check-up data of 1,764 Primary Care patients (PC patients) were retrospectively and cross-sectionally examined using a receiver-operating characteristic (ROC) curve to determine appropriate stratified-for-age cut-off of VAI, for the identification of PC patients with Metabolic Syndrome (MetS) according to the NCEP-ATP III criteria. The PC patients with higher VAI scores were subdivided into three groups according to VAI tertiles (i.e. PC patients with mild VAD, moderate VAD or severe VAD). Finally, VAD classes were compared to classical cardio- and cerebrovascular risk factors as independent predictors of coronary heart disease and/or myocardial infarction, transient ischemic attack and/or ischemic stroke.

Results
Moderate and severe VADs proved to be independently associated with cardiovascular events [(OR: 5.35; 95% CI: 1.92-14.87; p = 0.001) and (OR: 7.46; 95% CI: 2.64-21.05; p < 0.001) respectively]. Mild, moderate and severe VADs were found to be independently associated with cerebrovascular events [(OR: 2.73; 95% CI: 1.12-6.65; p = 0.027), (OR: 4.20; 95% CI: 1.86-9.45; p = 0.001) and (OR: 5.10; 95% CI: 2.14-12.17; p < 0.001) respectively].

Conclusions
Our study suggests that among Caucasian Sicilian subjects there are clear cut-off points of VAI able to identify a VAD strongly associated with cardiometabolic risk.
A new method for alignment of LC-MALDI-TOF data
Authors: Tang Zhiqun , Zhang Lihua , Cheema Amrita K , Ressom Habtom W 
Published: October 2011

Abstract

Background
In proteomics studies, liquid chromatography coupled to mass spectrometry (LC-MS) has proven to be a powerful technology to investigate differential expression of proteins/peptides that are characterized by their peak intensities, mass-to-charge ratio (m/z), and retention time (RT). The variable complexity of peptide mixtures and occasional drifts lead to substantial variations in m/z and RT dimensions. Thus, label-free differential protein expression studies by LC-MS technology require alignment with respect to both RT and m/z to ensure that same proteins/peptides are compared from multiple runs.

Methods
In this study, we propose a new strategy to align LC-MALDI-TOF data by combining quality threshold cluster analysis and support vector regression. Our method performs alignment on the basis of measurements in three dimensions (RT, m/z, intensity).

Results and conclusions
We demonstrate the suitability of our proposed method for alignment of LC-MALDI-TOF data through a previously published spike-in dataset and a new in-house generated spike-in dataset. A comparison of our method with other methods that utilize only RT and m/z dimensions reveals that the use of intensity measurements enhances alignment performance.
An automated cell-counting algorithm for fluorescently-stained cells in migration assays
Authors: Al-Khazraji Baraa K , Medeiros Philip J , Novielli Nicole M , Jackson Dwayne N 
Published: October 2011

Abstract
A cell-counting algorithm, developed in Matlab®, was created to efficiently count migrated fluorescently-stained cells on membranes from migration assays. At each concentration of cells used (10,000, and 100,000 cells), images were acquired at 2.5 ×, 5 ×, and 10 × objective magnifications. Automated cell counts strongly correlated to manual counts (r2 = 0.99, P < 0.0001 for a total of 47 images), with no difference in the measurements between methods under all conditions. We conclude that our automated method is accurate, more efficient, and void of variability and potential observer bias normally associated with manual counting.
Characterization upon electrical hysteresis and thermal diffusion of TiAl3O
x
dielectric film
Authors: Shi Lei , Liu Zhiguo 
Published: October 2011

AbstractIn this paper, we have investigated the electrical properties of TiAl3O
x
film as electrical gate insulator deposited by pulsed laser deposition and presented a simple method to describe the thermal diffusion behaviors of metal atoms at TiAl3O
x
/Si interfacial region in detail. The TiAl3O
x
films show obvious electrical hysteresis by the capacitance-voltage measurements after post-annealing treatment. By virtue of the diffusion models composed of TiAl3O
x
film and silicon, the diffusion coefficient and the diffusion activation energy of the Ti and Al atoms are extracted. It is valuable to further investigate the pseudobinary oxide system in practice.PACS: 77.55.-g; 81.15.Fg; 81.40.Gh.