bluuebunny/crossref_metadata_2025_split huggingface dataset:
The efficacy and safety of electroacupuncture for diabetic peripheral neuropathy: A protocol for a systematic review and meta-analysis
Authors: Wang Jiawei , Zhang Yajun , Wu Qiqi , Bian Zhiyuan , Luo Ning , Sun Jing , Yu Binyan , Fang Jianqiao 
Published: April 2024

Background
Diabetic peripheral neuropathy (DPN) is a chronic complication of diabetes mellitus, which is the most common neuropathy worldwide. Owing to the inadequacies of existing treatment methods, managing DPN remains a significant challenge. Studies suggest that electroacupuncture (EA) could potentially serve as a beneficial alternative treatment for this condition. Nevertheless, there is still inadequate proof of its therapeutic effectiveness and safety. As a result, the goal of this protocol is to methodically compile the data pertaining to the effectiveness and security of EA in the management of DPN.

Methods
To find appropriate randomized controlled trials (RCTs), nine reliable databases in the English and Chinese languages will be examined. RevMan5.3 will be used to combine the retrieved data and perform meta-analyses. The methodological quality of the included RCTs will be evaluated using the Cochrane Risk of Bias Assessment 2.0 tool. The Grades of Recommendations, Assessment, Development, and Evaluation (GRADE) system will be utilized to evaluate the degree of strength and certainty of the evidence. We will also perform publication bias, sensitivity and subgroup analyses.

Discussion
This protocol describes the intended scope and approach for a forthcoming systematic review and meta-analysis that will inform therapeutic decision-making by offering current information on the efficacy and safety of EA in the treatment of DPN. The results of the study will help standardize strategies for EA in the treatment of DPN.
Impact of methimazole‐induced hypothyroidism on postnatal swine
Authors: Fazioli James C. , Mulligan Margaret K. , Ison Erin K. , Pasternak J. Alex 
Published: April 2024

AbstractThyroid hormones regulate metabolic rate, nutrient utilization, growth, and development. Swine are susceptible to thyroid suppression in response to disease or environmental conditions, but the physiological impact of such disruption has not been established. The objective of this study was to evaluate the impact of hypothyroidism induced with the antithyroid medication methimazole (MMI). 10 mg/kg MMI significantly decreased circulating triiodothyronine (T3) for the duration of treatment but had only a transient effect on circulating thyroxine (T4). Thyroid tissue weight was significantly increased by more than 3.5‐fold in response to MMI treatment. Histologically, the eosinophilic colloid was largely absent from the thyroid follicle which displayed a disorganized columnar epithelium consistent with goiter. MMI induced hypothyroidism has no effect on growth rate over 28 days. Hepatic expression of genes associated with thyroid metabolism (DIO1, DIO2, and DIO3), lipid utilization (CD36, FASN, and ACACA), apoptosis (TP53, PERP, SIVA1, and SFN) and proliferation (CDK1, CDK2, CDK4, and CDKN1A) were unaffected by treatment. Collectively these results demonstrate that MMI induces mild systemic hypothyroidism and pronounced goiter, indicating a strong homeostatic central regulation within the hypothalamic pituitary thyroid axis. This combined with limited peripheral effects, indicates resilience to hypothyroidism in modern swine.
The Narrative Ordeal of Enduring Love: A Divine Comedy Recast
Authors: Botero Camacho Manuel , Rodríguez Pérez Miguel 
Published: April 2024

Abstract
This article establishes a connection between Ian McEwan’s Enduring Love and Dante Alighieri’s Divine Comedy. It defends that the narrative journey of Joe Rose, protagonist of McEwan’s novel, to recover his idyllic lost love resembles Dante’s voyage through Hell and Purgatory led by Virgil to the threshold of Earthly Paradise, where he meets Beatrice. The psychological and metaphorical hell to which Joe is subjected in the wake of a ballooning accident constitutes an ordeal in which, led by Jed Parry’s obsessive love, he confronts and purges the trauma in a redemptive arc that brings him closer to a promising yet uncertain paradise.
Treading the Spiral: Intermediality, Spatiality, and Materiality in Lance Olsen’s Theories of Forgetting
Authors: Uslu Gülşen Aslan 
Published: April 2024

Abstract
In his 2014 intermedial word-image novel Theories of Forgetting, Lance Olsen focuses on human life’s transience, impermanence, and fragility through his major characters, Alana and Hugh, and their children, who read their parents’ diaries. The ideas about the fleeting nature of human lives are presented through intermedial configurations in the novel which are rendered through experimental usage of the topography of the page, hypertextual design, and inclusion of photographs and various visual media which altogether redefine the spatiality and materiality of the novel. The initial construction of the spatial form in the work comes from postmodernist narrative elements. Spatiality and space gain further significance in the novel’s fictional world, or narrative space, with Robert Smithson’s earthwork Spiral Jetty, which aims to show change, regression, and disintegration in nature as well as being the main inspiration in the ekphrastic ventures of the novel. Alana, one of the characters, works on a short documentary film on Spiral Jetty, leading her to think and question time and space and how space is subject to change with time. Hugh, another character, is a traveler in distant places like Europe, the Middle East, and Jordan, all of which turn into metaphors that help to shape the narrative and represent the mental spaces of its characters. Besides these stories on and about space, the print book also becomes a site rich with photographs, visual media, and verbal text. Through intermediality, the novel portrays a complex depiction of space at structural, narrative, and material levels. Such a presentation of the stories with postmodernist elements and hypertext and a critical sensibility of the materiality of the print medium turn the work into an art object to be viewed and read.1
The Inability to Mourn: Representation of Collective Psychology in the “We”-Narrative of Yiyun Li’s “Immortality”
Authors: Feng Jie 
Published: April 2024

Abstract
This paper sets out to examine how the first-person plural narration form is used in diasporic Chinese American writer Yiyun Li’s short story “Immortality” to represent the collective loss of subjectivity – namely how she represents the consequences of that loss from a psychological perspective as part of her experiment in artistic innovation. It explores Li’s characterization – especially her realistic depiction of the collective narrators’ psychology under totalitarianism and how she allows their psychology to affect the form of her representation. I argue that although through the ventriloquy in English, Li has given the “we”-narrators a discursive voice to articulate their hidden thoughts and feelings – something not possible in their mother tongue, the “we”-narrators are unable to exceed their existential limitations to speak a purely personal language immune from official appropriation. Li’s story also underlines the extreme form as well as the emotional consequences of that collective loss of subjectivity, namely the “we”-community’s avoidance of mass melancholia in reaction to the tragic end of their compatriot victim of the dictatorship in order to preserve their prevailing collective ego-ideal.1
Bioinformatics, expression analysis, and functional verification of allene oxide synthase gene HvnAOS1 and HvnAOS2 in qingke
Authors: An Likun , Wang Ziao , Cui Yongmei , Yao Youhua , Bai Yixiong , Liu Yuehai , Li Xin , Yao Xiaohua , Wu Kunlun 
Published: April 2024

Abstract
Allene oxide synthase (AOS) is a key enzyme involved in the jasmonic acid (JA) synthesis pathway in plants. To explore its function on the regulatory mechanism of JA synthesis, we screened and identified two AOS genes HvnAOS1 and HvnAOS2 in qingke. Both HvnAOS1 and HvnAOS2 contained conserved heme-binding motif, which is most closely related to AtsAOS2, indicating controlled dehydration of fatty acid hydroperoxides to allene oxides. Molecular docking simulations identified the key amino acid sites that were important for heme binding and interaction with 13(S)-HPOT, respectively. The expression pattern also indicated that HvnAOS1 and HvnAOS2 were highly induced by JA, abscisic acid, and salicylic acid. Subcellular localization of HvnAOS1 and HvnAOS2 using transient expression of Agrobacterium tumefaciens showed the green fluorescent protein signal in the cell cytoplasm of the N. benthamiana leaves. Overexpression of HvnAOS1 and HvnAOS2 in Arabidopsis aos mutant restored male fertility and plant resistance to Botrytis cinerea, indicating that HvnAOS1 and HvnAOS2 can restore the functions of AOS in Arabidopsis aos mutant.
Aromatase deficiency due to novel CYP19A1 mutation: a rare cause of maternal and fetal virilization
Authors: Naseem Aamir , Zahid Muhammad , Arshad Kashan , Hussain Syed Saddam , Aftab Sommayya , Saeed Anjum , Cheema Huma Arshad 
Published: April 2024

Abstract

Objectives
Aromatase deficiency is a rare autosomal recessive condition due to a mutation in the CYP19A1 encoding aromatase enzyme. This enzyme protects the fetus and mother from excess androgens by converting them into estrogen. We are reporting a case of aromatase deficiency presented with atypical genitalia and maternal virilization due to a novel mutation in CYP19A1.

Case presentation
A 10-day-old newborn presented with atypical genitalia and a history of maternal virilization during pregnancy. On examination, the baby had a Prader score of 3. Further investigation revealed karyotype 46 XX, with a normal uterus and ovaries on ultrasonography. The hormonal profile of the baby was normal except for the raised follicle stimulating hormone (FSH). Maternal ultrasound revealed polycystic ovaries, and the hormonal profile was within the normal range with slightly raised testosterone. Whole exome sequencing was done, which reported that the baby was carrying a novel homozygous mutation of the CYP19A1 gene c.575G>C p. (Arg192Pro), confirming the diagnosis of aromatase deficiency.

Conclusions
Aromatase deficiency is a rare condition. A history of maternal virilization during pregnancy in a child born with atypical genitalia should alert physicians to consider aromatase deficiency.
Study on spent fuel heatup during spent fuel pool complete loss of coolant accident
Authors: Shih Yu-Huai 
Published: April 2024

Abstract
After years of operation, nuclear power plants accumulate a substantial amount of spent fuel stored in spent fuel pools. Prior to the completion of dry storage facilities, this spent fuel remains in the spent fuel pools for several decades. The progression of accidents in spent fuel pools leading to fuel damage typically spans several days or even weeks, which may lead people to overlook the importance of spent fuel pool safety. However, accidents involving spent fuel pools have a characteristic of low probability but high consequences. Their significance has been reemphasized, especially after the Fukushima accident. This study conducts an analysis of the scenario where a spent fuel pool experiences a complete loss of water. A plant equipped with a BWR-4 reactor and a MARK-I containment structure is used as the reference plant. The analysis utilizes the MAAP5 code to assess the impact of different fuel cooling times and ventilation flow rate of secondary containment building on the fuel temperature variation, considering only air circulation for cooling. Based on the analysis results, the plant utilizes the normal ventilation system of the reactor building, which can maintain the fuel temperature below 565 °C with a cooling time of 1 year. Additionally, it was found in the study that adequate ventilation flow rates and sufficient cooling time can ensure that the fuel temperature remains below 565 °C, thereby preserving fuel integrity.
The Grammar of Displacement: Entwined Stories in Ruth Almog and Jenny Erpenbeck
Authors: Ben-Horin Michal 
Published: April 2024

Abstract
Since 1945, the memory of the Holocaust and the Second World War has played a major role in Hebrew and German literature. This article suggests a comparative reading of prose works by Ruth Almog and Jenny Erpenbeck that deal with these memories, in light of the challenges identified by scholars of modern Hebrew and German literature. What literary devices do these writers use to respond to the catastrophe of the twentieth century? In what way do their stories intersect? To what extent do they reflect German-Hebrew dialogue? I argue that by combining historical details and fiction within a literary texture based on contiguity, variation, and intertextual relations, both writers call into question the binary of perpetrator versus victim and calamity versus redemption. I show how their grammar of displacement in Hebrew and in German helps account for the literary workings of memory and ethical justice.
A comparative analysis of shielding effectiveness in glass and concrete containers
Authors: ALMisned Ghada , Sen Baykal Duygu , Elshami Wiam , Susoy Gulfem , Kilic Gokhan , Tekin Huseyin Ozan 
Published: April 2024

Abstract
Nuclear waste control and related equipment play a vital role in safeguarding human health and the environment from the potential dangers of radioactive waste. This study addresses the critical challenge of enhancing the shielding effectiveness of container materials for nuclear waste management, with a focus on comparing the attenuation properties of glass and concrete composites. Our analysis revealed that the copper oxide-reinforced borosilicate glass container demonstrated a significant transmission factor (TF) value decrease by approximately 15% compared to steel–magnetite concrete at 1.3325 MeV, with a standard deviation of ±1.5%, indicating its lower protective characteristics. Nonetheless, it exhibited a 10% higher TF reduction compared to the cement–bitumen mix at the same energy level, with a precision error of ±1.2%. In addition, the half-value layer for this glass was determined to be 2.5 cm for 1.3325 MeV gamma rays, showing moderate shielding capacity. The study demonstrates that optimizing the oxide content in the borosilicate glass matrix significantly enhances its shielding effectiveness. This advancement in nuclear waste management materials is justified by our comprehensive evaluation, highlighting the potential of optimized glass materials to outperform traditional concrete in certain scenarios, thus contributing to the development of more effective nuclear waste containment solutions.
Role of history of traumatic life experiences in current psychosomatic manifestations
Authors: Boni Melania , Violi Simone , Ciaramella Antonella 
Published: April 2024

Abstract

Objectives
Although the relationship between traumatic experiences (TEs) and psychosomatic manifestations (pain, somatization, somatosensory amplification [SSA], and alexithymia) has been widely described, very few studies have investigated how these variables correlate with each other and with a history of TEs. The aim of this study was to investigate whether and how current psychosomatic manifestations are correlated with major and minor adult- and childhood TEs.

Methods
One hundred and forty-six patients (91 with pain) from the Pisa Gift Institute for Integrative Medicine Psychosomatics Lab., Italy, were assessed for pain, history of TEs (divided into major and minor based on whether or not they meet the DSM-5 Criterion A for post-traumatic stress disorder), alexithymia, somatization, and SSA.

Results
TEs were positively correlated with age, the sensorial dimension and intensity of pain, somatization, psychopathology index, SSA, and alexithymia. Using the somatization score (controlled for age) as a covariate, the previous correlations between psychosomatic dimensions and TEs lost their statistical significance: SSA (total TEs: from r = 0.30, p = 0.000 to r = −0.04, p = 0.652); alexithymia (total TEs: from r = 0.28, p = 0.001 to r = 0.04, p = 0.663); sensorial dimension of pain (total TEs: from r = 0.30, p = 0.015 to r = 0.12, p = 0.373); and pain intensity (total TEs: from r = 0.38, p = 0.004 to r = −0.15, p = 0.317). Interestingly, the tendency to report more intense pain was mainly predicted by minor TEs in childhood (β = 0.28; p = 0.030).

Conclusions
The number of lifetime TEs is positively correlated with the sensorial dimension and intensity of pain but not its affective and cognitive dimensions. However, the former relationship depends on the presence of somatization. The intensity of pain is associated with minor rather than major TEs, especially when they occur in childhood.
Golfers' Performance Is Improved More by Combining Foam Rolling and Dynamic Stretch to the Lead Hip Than Practice Golf Swinging
Authors: Hamada Yuji , Akasaka Kiyokazu , Otsudo Takahiro , Sawada Yutaka , Hattori Hiroshi , Kikuchi Yuto , Hall Toby 
Published: April 2024

Abstract
Hamada, Y, Akasaka, K, Otsudo, T, Sawada, Y, Hattori, H, Kikuchi, Y, and Hall, T. Golfers' performance is improved more by combining foam rolling and dynamic stretch to the lead hip than practice golf swinging. J Strength Cond Res 38(7): e391–e397, 2024—Warming up is considered effective in improving performance and preventing injury. Despite this, there have been few studies investigating warm-up programs in golf and whether specific factors contribute to improved performance. The purpose of this study was to examine the immediate effects of combined foam rolling and dynamic stretch (FR + DS) to the lead hip on golf swing performance, hip range of motion (ROM), and muscle strength in amateur golfers using a randomized crossover design. The study sample comprised 22 men (mean ± SD; age, 32.6 ± 8.5 years, body mass index (BMI), 23.4 ± 2.7 kg·m−2). Subjects were assigned to receive either FR + DS or repetitive golf swing practice (SW) before crossing over to the other intervention for another day. Measurements included golf swing performance (ball speed, club head speed, flight distance [“carry”], spin rate, and launch angle), hip internal rotation (IR), and external rotation (ER) ROM, as well as hip IR and ER muscle strength. Comparisons between groups were made before and after each intervention. For golf swing performance, FR + DS improved “carry” significantly more than SW (p < 0.05). No significant differences in golf swing performance other than “carry” were found. In addition, IR ROM and IR muscle strength of the lead hip were significantly increased in the FR + DS group (p < 0.05). FR + DS has effects on improving lead hip IR ROM and IR muscle strength, which may facilitate golfers' swing and “carry.” FR + DS shows promise as a warm-up method for amateur golfers who want to improve golf performance.
NSUN5 is essential for proper cell proliferation and differentiation of mouse preimplantation embryos
Authors: Liu Dan , Yamamoto Takuto , Wang Haoxue , Minami Naojiro , Honda Shinnosuke , Ikeda Shuntaro 
Published: April 2024

In brief
Proper early embryonic development in mammals relies on precise cellular signaling pathways. This study reveals that NSUN5 is crucial for the regulation of the Hippo pathway, ensuring normal proliferation and differentiation in mouse preimplantation embryos.

Abstract
NOL1/NOP2/Sun domain family, member 5 (NSUN5) is an enzyme belonging to the 5-methylcytosine (m5C) writer family that modifies rRNA and mRNA. Our data revealed an upregulation of Nsun5 at the two-cell stage of mouse preimplantation development, suggesting its significance in early embryonic development. Given m5C’s important role in stabilizing rRNA and mRNA and the Hippo signaling pathway’s critical function in lineage segregation during embryogenesis, we hypothesized that NSUN5 controls cell differentiation by regulating the expression of components of the Hippo signaling pathway in mouse early embryos. To examine this hypothesis, we employed Nsun5-specific small interfering RNAs for targeted gene silencing in mouse preimplantation embryos. Nsun5 knockdown resulted in significant developmental impairments including reduced blastocyst formation, smaller size of blastocysts, and impaired hatching from the zona pellucida. Nsun5 knockdown also led to decreased cell numbers and increased apoptosis in embryos. We also observed diminished nuclear translocation of yes-associated protein 1 (YAP1) in Nsun5 knockdown embryos at the morula stage, indicating disrupted cell differentiation. This disruption was further evidenced by an altered ratio of CDX2-positive to OCT4-positive cells. Furthermore, Nsun5 depletion was found to upregulate the Hippo signaling-related key genes, Lats1 and Lats2 at the morula stage. Our findings underscore the essential role of Nsun5 in early embryonic development by affecting cell proliferation, YAP1 nuclear translocation, and the Hippo pathway.
Management of Abnormal Frenulum and Gingival Enlargement in One Visit
Authors: Hartanti Hartanti , Kimera Assanian Dyah 
Published: April 2024

Gingival enlargement or excessive gingival growth, is a common occurrence in gingival disease, characterized by an increase in the size of the gingiva. Inflammatory gingival enlargement or inflammatory gingival enlargement is an inflammatory response to local irritation related to the gingiva. The most frequently performed treatment for gingival enlargement is gingivectomy. A high frenulum makes it easier for the gingival margin to be pulled so that plaque is easily trapped in the sulcus which results in periodontal disease and can be corrected with a frenectomy procedure. A 22-year-old female patient came to RSGM UMY complaining that her upper front gums had become enlarged so she was lacking self-confidence. Intraoral objective examination revealed enlarged gingiva on the interdental papillae of the maxillary anterior teeth (12, 13, and 21) which were rounded, light red in color with the surrounding gingiva, and had a smooth surface. There is a high frenulum with a height of 8 mm. A blanching test was carried out to examine the frenulum and the results were positive (+).Gingivectomy can be performed with a conventional scalpel, electrosurgery, chemosurgery, and laser. Conventional gingivectomy surgery performed with a small scalpel has been considered the most common method due to its ease of use, accuracy, and minimal tissue damage. Frenectomy can also be performed using various methods, such as using a scalpel, electrosurgery, or laser. Gingivectomy and frenectomy surgical procedures are effective in managing enlarged gingiva with a high frenulum