bluuebunny/crossref_metadata_2025_split huggingface dataset:
IL‐15 preferentially enhances functional properties and antigen‐specific responses of CD4+CD28null compared to CD4+CD28+ T cells
Authors: Alonso‐Arias Rebeca , Moro‐García Marco A. , Vidal‐Castiñeira José R. , Solano‐Jaurrieta Juan J. , Suárez‐García Francisco M. , Coto Eliecer , López‐Larrea Carlos 
Published: June 2011

SummaryOne of the most prominent changes during T‐cell aging in humans is the accumulation of CD28null T cells, mainly CD8+ and also CD4+ T cells. Enhancing the functional properties of these cells may be important as they provide an antigen‐specific defense against chronic infections. Recent studies have shown that IL‐15 does in fact play an appreciable role in CD4 memory T cells under physiological conditions. We found that treatment with IL‐15 increased the frequency of elderly CD4+CD28null T cells by the preferential proliferation of these cells compared to CD4+CD28+ T cells. IL‐15 induced an activated phenotype in CD4+CD28null T cells. Although the surface expression of IL‐15R α‐chain was not increased, the transcription factor STAT‐5 was preferentially activated. IL‐15 augmented the cytotoxic properties of CD4+CD28null T cells by increasing both the mRNA transcription and storage of granzyme B and perforin for the cytolytic effector functions. Moreover, pretreatment of CD4+CD28null T cells with IL‐15 displayed a synergistic effect on the IFN‐γ production in CMV‐specific responses, which was not observed in CD4+CD28+ T cells. IL‐15 could play a role enhancing the effector response of CD4+CD28null T cells against their specific chronic antigens.
Sex Matters: Evaluating Sex and Gender in Migraine and Headache Research
Authors: Peterlin B. Lee , Gupta Saurabh , Ward Thomas N. , MacGregor Anne 
Published: June 2011

(Headache 2011;51:839‐842)Significant sex differences exist in migraine and other headache disorders. Several hypotheses have been proposed to explain these differences, including fluctuations in sex hormones and receptor binding, genetic factors, differences in exposure to environmental stressors, as well as differences in response to stress and pain perception; but how valid are some of these findings and can we improve the quality of research in this field? It is notable that the preponderance of animal pain studies use male subjects to study a predominantly female disorder. Furthermore, with respect to headache and migraine sex differences, limited data have been derived from animal models. Additionally, although sex differences (based on the categorization of male vs female) may be more routinely evaluated in clinical headache research than in the basic science research, greater attention to potential differences across the life cycle of women (ie, premenopausal vs postmenopausal differences) and menstrual cycle is warranted. In this manuscript we define the differences between “sex” and “gender” and highlight the importance of their application and use in headache research. The enhanced recognition and implementation of attention to sex differences throughout the hormonal and life‐cycle phase in both human and animal research will only help to strengthen and further our understanding of migraine and may help guide the direction of future headache research.
Childhood Abuse and Migraine: Epidemiology, Sex Differences, and Potential Mechanisms
Authors: Tietjen Gretchen E. , Peterlin B. Lee 
Published: June 2011

(Headache 2011;51:869‐879)Migraine and maltreatment are both common conditions that are more prevalent in women. Epidemiological evidence supports an association between childhood abuse and headache, as well as pain in general, although some controversy exists based on methodological concerns of studying the influence of remote, traumatic, stigmatizing events in an often depressed population. There is a growing scientific body of knowledge regarding the neurobiological effects of abuse on brain function and structure that suggest a possible role of early life stress in the pathogenesis of migraine, and a differential impact based on sex. Advances in our understanding of the basic mechanisms by which an adverse environment interacts with and changes the genome, may suggest new treatment strategies.
A Double‐Blind Placebo‐Controlled Pilot Study of Sublingual Feverfew and Ginger (LipiGesicTMM) in the Treatment of Migraine
Authors: Cady Roger K. , Goldstein Jerome , Nett Robert , Mitchell Russell , Beach M.E. , Browning Rebecca 
Published: June 2011

(Headache 2011;51:1078‐1086)Background.— Therapeutic needs of migraineurs vary considerably from patient to patient and even attack to attack. Some attacks require high‐end therapy, while other attacks have treatment needs that are less immediate. While triptans are considered the “gold standard” of migraine therapy, they do have limitations and many patients are seeking other therapeutic alternatives. In 2005, an open‐label study of feverfew/ginger suggested efficacy for attacks of migraine treated early during the mild headache phase of the attack.Methods/Materials.— In this multi‐center pilot study, 60 patients treated 221 attacks of migraine with sublingual feverfew/ginger or placebo. All subjects met International Headache Society criteria for migraine with or without aura, experiencing 2‐6 attacks of migraine per month within the previous 3 months. Subjects had <15 headache days per month and were not experiencing medication overuse headache. Inclusion required that subjects were able to identify a period of mild headache in at least 75% of attacks. Subjects were required to be able to distinguish migraine from non‐migraine headache. Subjects were randomized 3:1 to receive either sublingual feverfew/ginger or a matching placebo and were instructed but not required to treat with study medication at the earliest recognition of migraine.Results.— Sixty subjects treated 208 evaluable attacks of migraine over a 1‐month period; 45 subjects treated 163 attacks with sublingual feverfew/ginger and 15 subjects treated 58 attacks with a sublingual placebo preparation. Evaluable diaries were completed for 151 attacks of migraine in the population using feverfew/ginger and 57 attacks for those attacks treated with placebo. At 2 hours, 32% of subjects receiving active medication and 16% of subjects receiving placebo were pain‐free (P = .02). At 2 hours, 63% of subjects receiving feverfew/ginger found pain relief (pain‐free or mild headache) vs 39% for placebo (P = .002). Pain level differences on a 4‐point pain scale for those receiving feverfew/ginger vs placebo were −0.24 vs −0.04 respectively (P = .006). Feverfew/ginger was generally well tolerated with oral numbness and nausea being the most frequently occurring adverse event.Conclusion.— Sublingual feverfew/ginger appears safe and effective as a first‐line abortive treatment for a population of migraineurs who frequently experience mild headache prior to the onset of moderate to severe headache.
The alveolar process of the edentulous maxilla in periodontitis and non‐periodontitis subjects
Authors: Lindhe Jan , Cecchinato Denis , Bressan Eriberto A. , Toia Marco , Araújo Mauricio G. , Liljenberg Birgitta 
Published: June 2011

Abstract
Background: Early implant failures may document that the bone tissue or the wound‐healing process following installation surgery was compromised. Subjects who have lost teeth for periodontal reasons exhibit more earlier implant failures than subjects who had experienced tooth loss for other reasons.
Aim: To describe the tissue of the fully healed extraction sites in subjects who had lost teeth as a result of periodontitis or for other reasons.
Material and methods: Thirty‐six otherwise healthy, partially dentate subjects with fully healed edentulous portions in the posterior maxilla were included. Nineteen of these subjects had lost teeth because of advanced periodontitis (group P) and 17 for other reasons (group NP). Using a trephine drill, a 4–6 mm long hard tissue specimen was harvested. The biopsies were decalcified, embedded in paraffin, sectioned, stained and examined.
Results: The edentulous posterior maxilla was comprised of 47.1 ± 11% lamellar bone, 8.1 ± 7.1% woven bone, 4.3 ± 3.1% osteoid and 16.5 ± 10.4% bone marrow. There were no significant differences in the tissue composition of post‐extraction sites of (i) P and NP subjects and (ii) premolar and molar sites.
Conclusion: More than 50% of the edentulous maxilla was comprised of mineralized bone (lamellar and woven bone). The bone trabeculae frequently appeared to have a random orientation. The direction of the trabeculae rather than the lack of mineralized bone tissue may explain the clinical impression that the bone in the posterior maxilla provides limited resistance to mechanical instrumentation.To cite this article: Lindhe J, Cecchinato D, Bressan EA, Toia M, Araújo M, Liljenberg B. The alveolar process of the edentulous maxilla in periodontitis and non‐periodontitis subjects. Clin. Oral Impl. Res. 23, 2012; 5–11 doi: 10.1111/j.1600‐0501.2011.02205.x
Masseter muscle thickness, chewing efficiency and bite force in edentulous patients with fixed and removable implant‐supported prostheses: a cross‐sectional multicenter study
Authors: Müller Frauke , Hernandez Marta , Grütter Linda , Aracil‐Kessler Luis , Weingart Dieter , Schimmel Martin 
Published: June 2011

Abstract
Objectives: Edentulous patients may be restored with conventional dentures (C/C), implant‐supported overdentures (IOD) or implant‐supported fixed dental prostheses (IFDP). Null‐hypotheses: chewing efficiency, maximum voluntary bite force (MBF) and masseter muscle thickness (MMT) are lower in patients with C/IOD compared with the patients with bimaxillary IFDPs. Both groups perform better than C/C and are inferior to fully dentate controls.
Material and methods: Ethical approval was obtained. For this multicenter cross‐sectional study, 80 patients were recruited. Four groups of different dental states comprised of either implant‐supported prostheses (C/IOD and IFDP/IFDP) or served as control‐groups (C/C and fully dentate D/D). Chewing efficiency was assessed with a two‐colour mixing ability test. MBF was measured bilaterally with a force gauge. Two dimensional ultrasonography was used to measure MMT bilaterally.
Results: Chewing efficiency in C/IOD and IFDP/IFDP (difference NS) was better than in C/C, but not as good as in D/D. MBF in C/IOD was lower than in IFDP/IFDP. Chewing efficiency and MBF were significantly lower in IFDP/IFDP, who had experienced chipping or fracture of the prosthetic superstructure. Median MMT of patients with implant‐supported prostheses was between those with C/C and fully dentate participants. There was no significant difference in MMT between C/IOD and IFDP/IFDP.
Conclusion: Supporting complete prostheses with oral implants seems to have positive effects on the thickness of the masseter muscle, maximum bite force as well as chewing efficiency. The type of implant‐supported prostheses may have an influence on the magnitude of the effect.
To cite this article: Müller F, Hernandez M, Grütter L, Aracil‐Kessler L, Weingart D, Schimmel M. Masseter muscle thickness, chewing efficiency and bite force in edentulous patients with fixed and removable implant‐supported prostheses: a cross‐sectional multicenter study. Clin. Oral Impl. Res. 23, 2012; 144–150.  doi: 10.1111/j.1600‐0501.2011.02213.x
Fracture strength of yttria‐stabilized tetragonal zirconia polycrystals crowns with different design: an in vitro study
Authors: Larsson Christel , Madhoun Sammah El , Wennerberg Ann , Vult von Steyern Per 
Published: June 2011

AbstractObjectives: The aim of this study was to evaluate the effect of different types and design of zirconia frameworks as well as the effect of different veneering ceramics on the fracture strength of crowns. The importance of different abutment materials was also evaluated.Materials and methods: Eighty cores, 40 in a fully‐sintered zirconia material and 40 in a pre‐sintered zirconia material were made. Twenty cores of each material were made with a core of even thickness shape (ES) and 20 were made with a core with anatomical shape (AS). The cores were divided into subgroups and veneered with one of two different veneering ceramics: a porcelain and a glass–ceramic material. In total eight groups of 10 crowns were made. They were all cemented onto abutments made of resin. One extra group of 10 AS, pre‐sintered zirconia cores veneered with glass–ceramic were made and cemented onto titanium abutments. All crowns underwent thermocycling and mechanical pre‐load and were finally loaded until fracture.Results: AS crowns withstood significantly higher loads than ES crowns (P‐value <0.001), and crowns with titanium abutments withstood significantly higher loads than crowns supported by abutments made of inlay pattern resin (P‐value <0.001). Three types of fracture were noted: minor and major fracture of the veneering ceramic, and complete fracture through core and veneer. ES crowns showed significantly more major fractures of the veneering ceramic than AS crowns.Conclusions: This in vitro study indicates that the design of the core, as well as the abutment support, significantly influences fracture load and fracture mode of yttria‐stabilized tetragonal zirconia polycrystals crowns.To cite this article: Larsson C, El Madhoun S, Wennerberg A, Vult von Steyern P. Fracture strength of yttria‐stabilized tetragonal zirconia polycrystals crowns with different design: an in vitro study. Clin. Oral Impl. Res. 23, 2012; 820–826. doi: 10.1111/j.1600‐0501.2011.02224.x
Short progression‐free survival predicts for poor overall survival in older patients with multiple myeloma treated upfront with novel agent‐based therapy
Authors: Migkou Magdalini , Kastritis Efstathios , Roussou Maria , Gkotzamanidou Maria , Gavriatopoulou Maria , Nikitas Nikitas , Mparmparoussi Despina , Matsouka Charis , Gika Dimitra , Terpos Evangelos , Dimopoulos Meletios A. 
Published: June 2011

AbstractObjectives:  To assess the importance of the quality of response and of early relapse in unselected elderly patients with myeloma treated upfront with novel agents.Methods:  We analyzed 135 unselected transplant‐ineligible patients older than 65 yr who were treated upfront with novel agent‐based regimens in a single center.Results:  On intent to treat, 81% of patients achieved a response (28% sCR/CR, 23% VGPR, and 30% PR). Median progression‐free survival (PFS) for patients who achieved sCR/CR was 31 vs. 20 months for VGPR and 23 months for PR (P = 0.048). Median overall survival (OS) for patients with sCR/CR was 62 months, 53 months for VGPR and 38 months for patients with PR (P = 0.028). Early relapse (PFS < 12 months) was more common in patients with PR (39% vs. 21% for VGPR vs. 3% for sCR/CR). Patients who relapsed or progressed <12 months from initiation of treatment had a median OS of 15.4 months compared with 53 months (P < 0.001) for patients who had a PFS > 12 months despite the fact that after relapse or progression most patients were treated again with novel agents. In multivariate analysis, short PFS was the most significant adverse prognostic factor affecting OS, associated with a 7.25‐fold (P < 0.0001) increase in the risk of death.Conclusion:  In newly diagnosed patients over 65 yr, treated upfront with novel agents achievement of CR and a PFS ≥12 months is associated with improved outcome. Patients who fail to respond or experience early relapse after primary therapy with novel agent‐based regimens should be encouraged to participate in clinical trials of novel agents and combinations.
Tongue position after deglutition in subjects with habitual open‐mouth posture under different functional conditions
Authors: Knösel M , Klein S , Bleckmann A , Engelke W 
Published: June 2011

To cite this article:
Knösel M, Klein S, Bleckmann A, Engelke W: Tongue position after deglutition in subjects with habitual open‐mouth posture under different functional conditions Orthod Craniofac Res 2011;14:181–188Structured AbstractAuthors –  Knösel M, Klein S, Bleckmann A, Engelke WObjective –  To test the null hypothesis of no significant differences in (1) the duration of the post‐deglutory, cranial tongue rest position (CTP) between different functional orofacial conditions and (2) the presence or absence of an oral screen (OS) in subjects with a habitual open‐mouth posture.Subjects –  Twenty‐nine subjects (aged 6–16; mean: 9.69 years; 13/16 girls/boys) were selected according to the inclusion criterion of a habitual, daytime open‐mouth posture.Methods –  Deglutition was screened at baseline during resting respiration using orofacial polysensography and simultaneous assessment of tongue‐to‐palate position and nasal airstream, during five functional intervals of 8 min each: F1 without instruction (RR); F2 the same, but including an oral screen (RROS); F3 with OS and the instruction to maintain a tongue‐to‐palate contact (IROS); F4 with OS and the instruction to perform tongue repositioning manoeuvres at the time of spontaneous swallowing (TRMOS); and F5 corresponds to F3 omitting OS (IR). Duration and frequency of deglutition were analysed descriptively as well as by anova and subsequent multiple comparisons, and the CTP was evaluated with chi‐square tests and paired comparisons at a significance level of 5%.Results –  Of 542 identified swallowing acts, 75% were accompanied by a post‐deglutory CTP. Mean duration of CTP increased for functional conditions RR/1.01s > RROS/2.56s > IR/3.21s > IROS/6.53s > TRMOS/6.58s. The null hypothesis (1) was rejected in comparison of resting respiration (F1, F2) with IROS and TRMOS, whereas the use of an oral screen alone did not significantly prolong the duration of CTP.
Long‐term effects of earlier initiated continuous Kangaroo Mother Care (KMC) for low‐birth‐weight (LBW) infants in Madagascar
Authors: Nagai Shuko , Yonemoto Naohiro , Rabesandratana Norotiana , Andrianarimanana Diavolana , Nakayama Takeo , Mori Rintaro 
Published: June 2011

AbstractAim:  To examine the long‐term effects of earlier initiated continuous Kangaroo Mother Care (KMC) for relatively stable low‐birth‐weight (LBW) infants in a resource‐limited country.Methods:  A randomized controlled trial with long‐term follow‐up was performed in LBW infants in Madagascar. Earlier continuous KMC (intervention group) was initiated as soon as possible within 24 h postbirth, and later continuous KMC (control group: conventional care) was initiated after complete stabilization. Outcome measures were mortality or readmission, nutritional indicators at 6–12 months postbirth and feeding condition at 6 months postbirth (ClinicalTrials.gov, NCT00531492).Results:  A total of 72 infants were followed for mortality or readmission at 6–12 months postbirth. There was no difference between the two groups (7/36 vs. 7/36, Risk ratio (RR), 1.00; 95% CIs, 0.39–2.56; p = 1.00). The proportion of exclusive breast feeding (EBF) at 6 months postbirth was significantly higher with earlier KMC than later KMC (12/29 vs. 4/26; RR 2.69; 95% CIs, 1.00–7.31; p = 0.04). There were no differences in nutritional indicators between the two groups at 6–12 months postbirth.Conclusion:  Earlier initiated continuous KMC results in a significantly higher proportion of EBF at 6 months postbirth. Further larger‐scale long‐term evaluations of earlier initiated continuous KMC for LBW infants are needed.
Celebrity Studies in the Long Eighteenth Century: An Interdisciplinary Overview
Authors: Wanko Cheryl 
Published: June 2011

AbstractThe work done to date on the development of celebrity culture in the long 18th century ranges across fields as diverse as theater and criminology, art and boxing, and music and oral culture, as scholars examine how celebrity operates within discrete segments of the public sphere as well as across them. Celebrity studies is more than a simple description of a star’s popularity. Instead, it examines how personal, social, media, political, and economic events create local conditions of popularity, how a celebrity’s popular images circulate within a culture, and what the celebrity means to a culture; it also traces how concepts of merit and fame change over time. Individual studies of celebrities and the fans, audiences, and readers who admire them are joined by interdisciplinary studies that best capture the breadth of celebrity’s foundations and effects.
Shakespearean Medievalism and the Limits of Periodization inCymbeline
Authors: Williams Deanne 
Published: June 2011

AbstractThe Renaissance developed the concept of a ‘middle age’ between the classical period and their own culture, while ‘medievalism’ is associated with the aesthetic nostalgia of the Pre‐Raphaelite Brotherhood. Although the idea of Shakespearean medievalism applies a Victorian category anachronistically to Shakespeare, it provides an opportunity to consider the coherence and significance of Shakespeare’s relationship to the Middle Ages, as well as the purpose and agenda behind his adaptations of medieval material. After the periodization debates of the 1990s, which sought to undermine many of the traditional disciplinary distinctions between the Middle Ages and Renaissance, scholars are now turning their attention to how the Renaissance invented the idea of the Middle Ages. This has produced a wide range of new perspectives on Shakespeare’s representation of the Middle Ages that includes the possibility that Shakespeare did not conceptualize history according to fixed periods, such as Medieval and Renaissance. This article argues that Chaucer’sFranklin’s Taleis a key source for Shakespeare’sCymbeline, and thatCymbeline’suse of theFranklin’s Taleprovides a key example of Shakespearean medievalism that resists the traditional borders and boundaries of periodization.
Stereoselectivity and conformational stability of haloalkane dehalogenase DbjA from Bradyrhizobium japonicum USDA110: the effect of pH and temperature
Authors: Chaloupkova Radka , Prokop Zbynek , Sato Yukari , Nagata Yuji , Damborsky Jiri 
Published: June 2011

The effect of pH and temperature on structure, stability, activity and enantioselectivity of haloalkane dehalogenase DbjA from Bradyrhizobium japonicum USDA110 was investigated in this study. Conformational changes have been assessed by circular dichroism spectroscopy, functional changes by kinetic analysis, while quaternary structure was studied by gel filtration chromatography. Our study shows that the DbjA enzyme is highly tolerant to pH changes. Its secondary and tertiary structure was not affected by pH in the ranges 5.3–10.3 and 6.2–10.1, respectively. Oligomerization of DbjA was strongly pH‐dependent: monomer, dimer, tetramer and a high molecular weight cluster of the enzyme were distinguished in solution at different pH conditions. Moreover, different oligomeric states of DbjA possessed different thermal stabilities. The highest melting temperature (Tm = 49.1 ± 0.2 °C) was observed at pH 6.5, at which the enzyme occurs in dimeric form. Maximal activity was detected at 50 °C and in the pH interval 7.7–10.4. While pH did not have any effect on enantiodiscriminination of DbjA, temperature significantly altered DbjA enantioselectivity. A decrease in temperature results in significantly enhanced enantioselectivity. The temperature dependence of DbjA enantioselectivity was analysed with 2‐bromobutane, 2‐bromopentane, methyl 2‐bromopropionate and ethyl 2‐bromobutyrate, and differential activation parameters and were determined. The thermodynamic analysis revealed that the resolution of β‐bromoalkanes was driven by both enthalpic and entropic terms, while the resolution of α‐bromoesters was driven mainly by an enthalpic term. Unique catalytic activity and structural stability of DbjA in a broad pH range, combined with high enantioselectivity with particular substrates, make this enzyme a very versatile biocatalyst.EnzymeEC3.8.1.5 haloalkane dehalogenase.