bluuebunny/crossref_metadata_2025_split huggingface dataset:
Feedback‐Based Alcohol Interventions for Mandated Students: An Effectiveness Study of Three Modalities
Authors: Alfonso Jacqueline , Hall Thomas V. , Dunn Michael E. 
Published: February 2012

The present study used a randomized clinical trial design to examine the effectiveness of personalized alcohol feedback delivered individually, in a group and via computer on alcohol use and related negative consequences in a sample of 173 college students referred for alcohol‐related violations. Findings revealed statistically significant reductions in alcohol use and related harms for the individually delivered intervention, with significant reductions in alcohol‐related harms for the electronically delivered intervention. No statistically significant results were found for the group‐delivered intervention or between groups, and a main effect of time was noted for all outcome variables. This study adds to the literature by being the first randomized clinical trial to include analyses of an empirically supported individually delivered personalized alcohol feedback intervention with more cost‐effective group‐delivered and electronically delivered feedback formats within a single research design, by expanding the range of participant drinking habits reported at baseline to include all drinking levels and not solely those classified as ‘heavy drinking’ and by providing anonymity pre‐intervention and post‐intervention given the potential demand characteristics to underreport illegal and/or illicit behaviours in this vulnerable population. Copyright © 2012 John Wiley & Sons, Ltd.Key Practitioner Message

Personalized alcohol feedback delivered in a one‐on‐one, face‐to‐face format serves to decrease both alcohol use and harms in mandated college students.
The use of web‐delivered personalized alcohol feedback may be clinically useful when working with a mandated student population to reduce alcohol‐related harms.
Personalized alcohol feedback delivered in a group setting may not be indicated for use with a mandated student population as it does not demonstrate decreases in either alcohol use or harms, possibly because of the normalization of deviant behaviour.
Three 3D Metal–Quinolone Complexes Based on Trimetallic or Rod‐Shaped Secondary Building Units
Authors: Xiao Dong‐Rong , He Jiang‐Hong , Sun Dian‐Zhen , Chen Hai‐Yan , Yan Shi‐Wei , Wang Xin , Yang Juan , Yuan Ruo , Wang En‐Bo 
Published: February 2012

AbstractThe self‐assembly of quinolones with metal salts in the presence of aromatic polycarboxylato ligands or chloride anions produced three novel 3D metal–quinolone coordination polymers, namely [Cu3(ppa)2(oba)2(H2O)4]·H2O (1), [Cd3(ppa)2(bpdc)2(H2O)2]·5H2O (2), and [Cd2(sara)2(μ2‐Cl)2]·5H2O (3) [ppaH = pipemidic acid, saraH = sarafloxacin, oba = 4,4′‐oxybis(benzoate), bpdc = 4,4′‐biphenyldicarboxylate]. Their structures were determined by single‐crystal X‐ray diffraction analyses, and they were further characterized by elemental analyses, IR spectra, X‐ray powder diffraction, and TG analyses. Compound 1 represents a novel 3D (3,4)‐connected network with a (6·82)2(6·82)2(62·82·102) topology constructed from Cu atoms and ppa ligands. Compound 2 represents the first example of a 3D metal–quinolone complex with a (3,4,6)‐connected (52·6)2(52·64)(54·66·72·8·92) topology. Compound 3 is an unprecedented 3D metal–quinolone complex constructed from Cl– ions connecting the {Cd(sara)}nn+ layers. Furthermore, the luminescent properties of compounds 2 and 3 are discussed.
Rare‐Earth Melonates LnC6N7(NCN)3·xH2O (Ln = La, Ce, Pr, Nd, Sm, Eu, Tb; x = 8–12): Synthesis, Crystal Structures, Thermal Behavior, and Photoluminescence Properties of Heptazine Salts with Trivalent Cations
Authors: Makowski Sophia J. , Schwarze Arne , Schmidt Peter J. , Schnick Wolfgang 
Published: February 2012

AbstractThe rare‐earth melonates LnC6N7(NCN)3·xH2O (Ln = La, Ce, Pr, Nd, Sm, Eu, Tb; x = 8–12) have been synthesized by metathesis reactions in aqueous solution and characterized by single‐crystal and powder XRD, FTIR spectroscopy, thermal analysis, and photoluminescence studies. Powder XRD patterns revealed isotypism of the La–Sm compounds. The structure of LaC6N7(NCN)3·8H2O has been solved and refined from single‐crystal diffraction data and those of the remaining salts have been refined from powder XRD data by Rietveld refinement. In the crystal structures, the melonate entities are arranged in corrugated layers, which alternate with layers of crystal water molecules. The lanthanide ions are coordinated by two melonate and six water molecules. LnC6N7(NCN)3·xH2O (Ln = Eu, Tb; x = 9–12) have also been investigated by photoluminescence studies. Neither hydrated nor dehydrated europium melonate exhibits luminescence under UV excitation, whereas photoluminescence studies of terbium melonate showed green emission with a maximum at 545 nm due to the 5D4→7F5 transition. Thermal analysis revealed rather low thermal stability of the rare‐earth melonates, which is probably due to the tight binding of crystal water that results in hydrolytic decomposition at elevated temperatures.
On the Directing Effect of Boronate Groups in the Lithiation of Boronated Thiophenes
Authors: Borowska Elena , Durka Krzysztof , Luliński Sergiusz , Serwatowski Janusz , Woźniak Krzysztof 
Published: February 2012

AbstractAn investigation of thiophene boronates has revealed the usefulness of a metalation reaction in the synthesis of various lithiated thiophene boronates, which were further converted to functionalized thiopheneboronic derivatives. The lithiation of 2‐ and 3‐thienylboronic N‐butyldiethanolamine (BDEA) esters with lithium diisopropylamide and lithium 2,2,6,6‐tetramethylpiperidide showed that both boronated thiophenes were readily deprotonated. In the latter case, lithiation at the 2‐position adjacent both to sulfur and the borocanyl group is thermodynamically favoured due to the significant stabilizing effect of the borocanyl group. Further derivatization with a range of electrophiles followed by hydrolysis afforded various 2‐substituted 3‐thiopheneboronic acids. Lithiation of the corresponding thiopheneboronic “ate” complexes of the type [ThB(OR)3]Li revealed that the 2‐thienyl derivatives could not be effectively deprotonated, whereas the “ate” complex, [3‐ThB(OEt)3]Li, was selectively lithiated with nBuLi at C‐2. This points to a directing effect of the anionic boronate moiety. The resulting bimetallic species, [(2‐Li‐3‐Th)B(OEt)3]Li, underwent ring‐closing dimerization upon heating to give, after subsequent hydrolysis, 4,8‐dihydro‐4,8‐dihydroxy‐p‐diborino[2,3‐b:5,6‐b′]dithiophene ― a cyclic diborinic acid. A computational study of the lithiation of boronated thiophenes and furans proved that boronation decreases ring‐proton acidity. This effect is much stronger for the boronic “ate” complexes than for the corresponding neutral BDEA esters. Calculations of the transition states have shown that the specific directing effect of boronate groups in 3‐thienyl derivatives is due to intramolecular oxygen–lithium coordination.
Reactions of Fluorinated Organic Radicals in Aqueous Media
Authors: Barata‐Vallejo Sebastián , Postigo Al 
Published: February 2012

AbstractFluorinated radicals in water are shown to enable a useful array of synthetic organic transformations, reflecting these intermediates' distinct behavior in water or aqueous media. The enhanced reactivities of perfluroalkyl radicals in water facilitate their addition reactions to carbon–carbon and carbon–heteroatom multiple bonds. Activated and unactivated unsaturated substrates are equally reactive candidates for radical perfluoroalkylation reactions in aqueous systems. Parallel behavior of perfluorinated radicals in organic solvents and in water is presented, demonstrating the scope of reactions based on fluorinated radicals in aqueous media, as well as the ease of carbocyclic construction.
Access to Optically Active 3‐Aminopiperidines by Ring Expansion of Prolinols: Thermodynamic versus Kinetic Control
Authors: Cochi Anne , Pardo Domingo Gomez , Cossy Janine 
Published: February 2012

Abstract3‐Aminopiperidines are of great interest because they can possess a wide range of biological activity depending on the nitrogen substituents. Different approaches their synthesis are presented and the most efficient is a ring expansion of prolinols induced by XtalFluor‐E (diethylaminodifluorosulfinium tetrafluoroborate) in the presence of tetrabutylammonium azide, via an aziridinium intermediate, followed by the reduction of the corresponding azide. Under kinetic conditions, a 2‐(azidomethyl)pyrrolidine/3‐azidopiperidine ratio of 0:100 can be attained depending on the substituents present on the prolinol.
Cycloaddition of C,C‐Disubstituted Ketonitrones with Acceptor Methylenecyclopropanes and Subsequent Rearrangement Cascade of 5‐Spirocyclopropane‐isoxazolidines
Authors: Tran Tung Q. , Diev Vyacheslav V. , Starova Galina L. , Gurzhiy Vladislav V. , Molchanov Alexander P. 
Published: February 2012

AbstractA new reaction cascade to give tricyclic cores of 2,4‐dihydro‐1H‐azeto[1,2‐a]quinolines (benzocarbacephems) and pyrrolo[1,2‐a]quinolines starting from acyclic N‐aryl ketonitrones and acceptor ring substituted methylenecyclopropanes has been reported. This reaction includes 1,3‐dipolar cycloaddition of N‐aryl‐C,C‐diaryl or N‐aryl‐C,C‐bis(methoxycarbonyl) nitrones 1 to the double bond of dimethyl methylenecyclopropane‐1,2‐dicarboxylate 2 or benzylidenecyclopropane‐1,1‐dicarboxylate 3, followed by Brandi–Guarna rearrangement of the initially formed 5‐spirocyclopropane‐isoxazolidine cycloadducts to give 2,4‐dihydro‐1H‐azeto[1,2‐a]quinolines 4 or pyrrolo[1,2‐a]quinolines 6.
Repression of miR‐142 by p300 and MAPK is required for survival signalling via gp130 during adaptive hypertrophy
Authors: Sharma Salil , Liu Jing , Wei Jianqin , Yuan Huijun , Zhang Taifang , Bishopric Nanette H. 
Published: February 2012

AbstractAn increase in cardiac workload, ultimately resulting in hypertrophy, generates oxidative stress and therefore requires the activation of both survival and growth signal pathways. Here, we wanted to characterize the regulators, targets and mechanistic roles of miR‐142, a microRNA (miRNA) negatively regulated during hypertrophy. We show that both miRNA‐142‐3p and ‐5p are repressed by serum‐derived growth factors in cultured cardiac myocytes, in models of cardiac hypertrophy in vivo and in human cardiomyopathic hearts. Levels of miR‐142 are inversely related to levels of acetyltransferase p300 and MAPK activity. When present, miR‐142 inhibits both survival and growth pathways by directly targeting nodal regulators p300 and gp130. MiR‐142 also potently represses multiple components of the NF‐κB pathway, preventing cytokine‐mediated NO production and blocks translation of α‐actinin. Forced expression of miR‐142 during hypertrophic growth induced extensive apoptosis and cardiac dysfunction; conversely, loss of miR‐142 fully rescued cardiac function in a murine heart failure model. Downregulation of miR‐142 is required to enable cytokine‐mediated survival signalling during cardiac growth in response to haemodynamic stress and is a critical element of adaptive hypertrophy.
An ns‐3 architecture for simulating joint radio resource management strategies in interconnected WLAN and UMTS networks
Authors: Monego Hermes Del , Carneiro Gustavo , Oliveira José Manuel , Ricardo Manuel 
Published: February 2012

ABSTRACTInterconnection of different access network technologies is an important research topic in mobile telecommunications systems. In this paper, we propose an ns‐3 architecture for simulating the interconnection of wireless local area network (WLAN) and Universal Mobile Telecommunications System (UMTS). This architecture is based on the architecture proposed by the Third Generation Partnership Project, being the use of virtual interfaces as its main innovation. In order to demonstrate the value of the proposed simulation framework, we implemented the UMTS and WLAN interconnection considering three joint radio resource management strategies for distributing arriving calls. From the simulations results, we can conclude that the proposed simulation architecture is suitable to test and evaluate performance aspects related to the interconnection and joint management of UMTS and WLAN technologies. Copyright © 2012 John Wiley & Sons, Ltd.
Featured structures of fire residue of high‐impact polystyrene/organically modified montmorillonite nanocomposites during burning
Authors: Zhang Jun , Bai Maojuan , Wang Yong , Xiao Fengyan 
Published: February 2012

SUMMARYThe structures and constituents of fire residue of high‐impact polystyrene/organically modified montmorillonite (HIPS/OMMT) nanocomposite during burning was investigated using scanning electron microscopy, thermogravimetric analysis, X‐ray diffraction analysis, and elementary analysis techniques and based on quenched samples obtained during the cone calorimeter test. It was found that during burning the HIPS/OMMT nanocomposite tends to form a two‐layer structure of fire residue on the surface of material. This two‐layer structure contains a thin and condensed skin layer at the top and a loose and expanded cellular layer under the skin layer. The skin structure contains many small sizes of voids, while the cellular structure includes a large number of large‐size voids. Both the skin and cellular layers are composed of mainly montmorillonite platelets, which are aggregated to form a nanoscale network structure, in which certain amounts of carbonaceous char components are trapped during burning but decompose above approximately 550°C in the presence of oxygen. Finally, an idealized model was put forward to explain the featured structures of fire residues for the nanocomposite studied. Copyright © 2012 John Wiley & Sons, Ltd.
Colorimetric artificial nose for baijiu identification
Authors: Ya Zhang , He Kun , Lu Zhong‐ming , Yi Bin , Hou Chang‐jun , Shan Shen , Huo Dan‐qun , Luo Xiao‐gang 
Published: February 2012

ABSTRACTBased on a colorimetric sensor array, five commercial baijiu were analysed by a simple colorimetric artificial nose. Utilizing porphyrin, porphyrin derivatives and chemically responsive dyes as sensitive materials, the sensor array of the artificial nose showed a unique pattern of colorific changes upon its exposure to baijiu. Principal component analysis (PCA) and hierarchical cluster analysis (HCA) were employed to investigate the presence of classes inside the sample and linear discriminant analysis (LDA) was employed to identify baijiu of different fragrances. The results of PCA and HCA analyses suggested that the colorimetric artificial nose might characterize the types of baijiu according to their trace components, rather than the raw materials, fermentation method, manufacturing process and other conditions. The accuracy in terms of the classification of each baijiu flavours using LDA was 100% and confirmed the great potential of colorimetric artificial nose in the detection of baijiu flavour styles. Copyright © 2012 John Wiley & Sons, Ltd.
Synthesis of new organophosphorus compounds using the atherton–todd reaction as a versatile tool
Authors: Wagner Sebastian , Rakotomalala Muriel , Bykov Yana , Walter Olaf , Döring Manfred 
Published: February 2012

AbstractThis article discusses the behavior of seven organophosphorus compounds under Atherton–Todd conditions. Therefore, the reactivity and selectivity of different (phen)oxaphosphinines, dioxaphosphinines, dioxaphosphinanes, and diphenylphosphine oxide with three nucleophiles were systematically studied. The results prove the versatility of the Atherton–Todd reaction to a broad range of organophosphorus compounds with different phosphorus environments and reactive PH bonds. The nucleophiles studied in this article were chosen as model substrates for amines and alcohols. Because organophosphorus molecules are important and versatile compounds, for a broad field of applications, novel synthetic approaches are of interest to both academia and industry. As an example, the single‐step synthesis of the bridged 1,3‐phenylene bis(diphenylphosphinate) with potential flame‐retardant properties was added to this study. In addition, the reaction is utilized for the synthesis of a novel organophosphorus anhydride. © 2012 Wiley Periodicals, Inc. Heteroatom Chem 23:216–222, 2012; View this article online at wileyonlinelibrary.com. DOI 10.1002/hc.21006
Synthesis and tuberculostatic activity of novel N′‐methyl‐4‐(pyrrolidin‐1‐yl)picolinohydrazide and N′‐methylpyrimidine‐2‐carbohydrazide derivatives
Authors: Bogdanowicz Agnieszka , Foks Henryk , Gobis Katarzyna , Augustynowicz‐Kopec Ewa 
Published: February 2012

AbstractThe synthesis of N′‐methyl‐4‐(pyrrolidin‐1‐yl)picolinohydrazide and N′‐methyl‐pyrimidine‐2‐carbohydrazide derivatives (5a and 5b) was carried out. These compounds were used as starting materials to obtain methyl N′‐methylhydrazinecarbodithioates 6a and 6b, which, on reaction with either triethylamine or hydrazine, gave corresponding 1,3,4‐oxadiazioles 7a and 7b or 1,2,4‐triazoles 9a and 9b with the free NH2 group at the N‐4 position, respectively. Compounds 8a–e, particularly containing cyclic amines at N‐4 of the 1,2,4‐triazole ring, were also obtained. Synthesized compounds were tested in vitro for their activity against Mycobacterium tuberculosis. The structure–activity relationship analysis for obtained compounds was done. © 2012 Wiley Periodicals, Inc. Heteroatom Chem 23:223–230, 2012; View this article online at wileyonlinelibrary.com. DOI 10.1002/hc.21008
Preliminary evaluation of the reliability and validity of the Shame and Stigma Scale in head and neck cancer
Authors: Kissane David W. , Patel Snehal G. , Baser Raymond E. , Bell Rachel , Farberov Maria , Ostroff Jamie S. , Li Yuelin , Singh Bhuvanesh , Kraus Dennis H. , Shah Jatin P. 
Published: February 2012

AbstractBackgroundFacial disfigurement from head and neck cancer can lead to the development of shame and a perception of stigma. We sought to develop the Shame and Stigma Scale (SSS) to measure this.Items were administered to 104 patients with squamous cell carcinoma of the oral cavity, together with measures of quality of life and adaptation. Exploratory factor analysis and item response theory (IRT) models assessed its psychometric properties.ResultsA 20‐item SSS had a Cronbach's alpha of 0.94 and 4 factors: shame with appearance, sense of stigma, regret, and speech/social concerns. These factors show satisfactory internal validity, convergent validity with the Functional Assessment of Cancer Therapy‐General (FACT‐G) and Functional Assessment of Cancer Therapy‐Head and Neck (FACT‐H&N), Demoralization Scale and Patient Health Questionnaire (PHQ) Depression, and divergent validity with the Social Desirability Scale. The items displayed desirable properties in factor‐specific (IRT) models.ConclusionFurther validation studies are worthwhile to confirm this factor structure, reliability, and validity, and generalizability to all head and neck cancers. © 2012 Wiley Periodicals, Inc. Head Neck, 2013
Lysyl oxidase and enhancement of cell proliferation and angiogenesis in oral squamous cell carcinoma
Authors: Shih Yin‐Hua , Chang Kuo‐Wei , Chen Michael Yuanchien , Yu Cheng‐Chia , Lin Dan‐Jae , Hsia Shih‐Min , Huang Heng‐Li , Shieh Tzong‐Ming 
Published: February 2012

AbstractBackgroundLysyl oxidase (LOX) is a copper‐dependent enzyme that cross‐links collagen and elastin in the extracellular matrix. LOX overexpressed in various tumors. The manner in which LOX affects tumor growth remains controversial.MethodsChemical treatment and gene transfection were used to induce LOX overexpression or inhibition in cell lines SAS and SVEC4‐10. LOX mRNA, protein, and activity were confirmed before tube formation assay and tumorigenesis. The microvessels in the tumor section were detected by immunostaining CD31‐positive endothelial cells.ResultsLOX overexpression and copper induction of LOX activity increased SVEC4‐10 tube formation. LOX silencing and β‐aminopropionitrile inhibition of LOX activity had opposite effects. LOX overexpression increased proliferation and proliferating cell nuclear antigen expression. High LOX expression clones increased tumor size in a tumorigenesis model. The microvascular numbers were higher in LOX overexpression tumors than in control tumors.ConclusionLOX can induce cell proliferation and angiogenesis in oral squamous cell carcinoma. © 2012 Wiley Periodicals, Inc. Head Neck, 2013
Early postoperative epidermal growth factor receptor inhibition: Safety and effectiveness in inhibiting microscopic residual of oral squamous cell carcinoma in vivo
Authors: Sano Daisuke , Gule Maria K. , Rosenthal David I. , Bell Diana , Yates Jeremy , El‐Naggar Adel K. , Myers Jeffrey N. 
Published: February 2012

AbstractBackgroundThe local‐regional failure of advanced oral squamous cell carcinoma (OSCC) after surgery results from the regrowth of residual tumor cells that may be stimulated by epidermal growth factor receptor (EGFR) ligands during the wound healing process.MethodsThe level of EGFR ligands in human drain fluids (DFs) from OSCC resection and remote flap donor site were determined. A mouse model of microscopic residual OSCC was established and treated with cetuximab to measure tumor growth, survival, and cervical lymph node metastases. A mouse model of wound healing was also established to assess the effect of an EGFR antibody on the wound healing process.ResultsEGFR ligands are found in sites from OSCC resection. EGFR targeted therapy can delay tumor regrowth in a microscopic residual disease model of OSCC without significant effects on local wound healing.ConclusionThese results provide a strong rationale for clinical evaluation of this approach to treat patients with local‐regionally advanced OSCC. © 2012 Wiley Periodicals, Inc. Head Neck, 2013
Quality of life for patients with hypopharyngeal cancer after different therapeutic modalities
Authors: Lee Tsung‐Lun , Wang Ling‐Wei , Mu‐Hsin Chang Peter , Chu Pen‐Yuan 
Published: February 2012

AbstractBackgroundConcurrent chemoradiation therapy (CCRT) and transoral laser microsurgery (TLM) have become therapeutic selections for organ preservation in patients with hypopharyngeal cancer.MethodsOur cross‐sectional, observational study assesses quality of life (QOL) in patients with hypopharyngeal cancers receiving TLM plus radiotherapy (RT) compared with those treated with CCRT only or radical open surgery (nearly all of whom also received RT or CCRT). QOL was assessed at least 6 months posttreatment.ResultsThe study included 87 patients. Patients receiving open surgery reported significantly more sensory and speech disturbances than the others and more dental problems than the TLM group; the CCRT group experienced more xerostomia than the others, more weight loss, and dysphagia than the open surgery group; TLM patients experience fewer difficulties in emotional and social functioning, financial impact, and cough.ConclusionTLM may provide comparable, if not better, QOL for patients relative to the other therapeutic regimens for selective advanced cases of hypopharyngeal cancer. © 2012 Wiley Periodicals, Inc. Head Neck, 2013