bluuebunny/crossref_metadata_2025_split huggingface dataset:
ChemInform Abstract: Discovery of a Novel Nitroimidazolyl—Oxazolidinone Hybrid with Potent anti Gram‐Positive Activity: Synthesis and Antibacterial Evaluation.
Authors: Foroumadi Alireza , et al. et al. 
Published: April 2011

AbstractAmong the three investigated compounds, (Ic) exhibits the most promising activity against Gram‐positive bacteria at non‐cytotoxic concentrations.
ChemInform Abstract: Synthesis and in vitro Antimycobacterial Activity of 8‐OCH3 Ciprofloxacin Methylene and Ethylene Isatin Derivatives.
Authors: Feng Lian‐Shun , Liu Ming‐Liang , Zhang Shu , Chai Yun , Wang Bo , Zhang Yi‐Bin , Lv Kai , Guan Yan , Guo Hui‐Yuan , Xiao Chun‐Ling 
Published: April 2011

AbstractA series of novel 8‐OMe ciprofloxacin methylene and ethylene isatin derivatives (I) with remarkable improvement in lipophilicity are synthesized and evaluated for their in vitro activity against some mycobacteria.
ChemInform Abstract: Antiproliferative Activity of Phenylbutyrate Ester of Haloperidol Metabolite II [(.+‐.)‐MRJF4] in Prostate Cancer Cells.
Authors: Marrazzo Agostino , Fiorito Jole , Zappala Laura , Prezzavento Orazio , Ronsisvalle Simone , Pasquinucci Lorella , Scoto Giovanna M. , Bernardini Renato , Ronsisvalle Giuseppe 
Published: April 2011

AbstractMRJF4 (I) inhibits cell growth in the prostate cancer cell lines LNCaP and PC3.
ChemInform Abstract: Modulation of PPAR Subtype Selectivity. Part 2. Transforming PPARα/γ Dual Agonist into α Selective PPAR Agonist Through Bioisosteric Modification.
Authors: Bahekar Rajesh , et al. et al. 
Published: April 2011

AbstractBioisosteric replacement of the rigid oxazole ring of a previously reported PPARα/γ dual agonist with a flexible lipophilic tail leads to a series of oxime containing benzyl dioxanecarboxylic acid derivatives.
ChemInform Abstract: Aliphatic Aldehydes in the Synthesis of Carbo‐ and Heterocycles. Part 1. Synthesis of Three‐, Four‐, and Five‐Membered Rings
Authors: Dyachenko V. D. , Karpov E. N. 
Published: April 2011

AbstractReview: data published over the last 12 years are summarized and systematized; 177 refs.
Asymmetric polymerizations of chiral 4‐benzyl‐2‐ethynyloxazoline with rhodium catalyst and chiroptical properties of the polymers
Authors: Onimura Kenjiro , Shintaku Keiko , Rattanatraicharoen Poompat , Yamabuki Kazuhiro , Oishi Tsutomu 
Published: April 2011

AbstractOptically active 4‐alkyl‐2‐ethynyloxazoline derivatives (BnEOx) were polymerized with rhodium catalysts. The polymerization in toluene produced polymer with the highest absolute values of specific rotation ([α]D = −77.3°). The yields, molecular weights, and specific rotations of poly(BnEOx)s were influenced by polymerization conditions. The copolymerization with phenylacetylene (PA) was effective to increase the molecular weight of the copolymer. It is interesting to note that the copolymers exhibited positive specific rotations ([α]D = +4.7° to +62.5°) despite the fact that [α]Ds of BnEOx and the homopolymer are negative sign. The chiroptical properties were investigated by the chiral/achiral copolymerization of BnEOx with PA. The copolymerizations of BnEOx with PA gave copolymers containing higher order structure such as one‐handed helical conformation. Furthermore, induced Cotton effects were observed in the π–π* transition region of conjugated main chain depending a complex of these polymers with zinc triflate salt in tetrahydrofuran solution, indicating the formation of chiral supramolecular aggregates. Chirality, 2011. © 2011 Wiley Periodicals, Inc.
Experimental and theoretical studies of vacuum‐ultraviolet electronic circular dichroism of hydroxy acids in aqueous solution
Authors: Fukuyama Takayuki , Matsuo Koichi , Gekko Kunihiko 
Published: April 2011

AbstractThe electronic circular dichroism (ECD) spectra of three L‐hydroxy acids (L‐lactic acid, (+)‐(S)‐2‐hydroxy‐3‐methylbutyric acid, and (−)‐(S)‐2‐hydroxyisocaproic acid) were measured down to 160 nm in aqueous solution using a vacuum‐ultraviolet ECD spectrophotometer. To assign the two positive peaks around 210 and 175 nm and the one negative peak around 190 nm in the observed spectra, the ECD spectrum of L‐lactic acid was calculated using time‐dependent density functional theory (DFT) for the optimized structures by DFT and a continuum model. The observed ECD spectrum was successfully reproduced as the average spectrum for four optimized structures with seven water molecules that localized around the COO− and OH groups of L‐lactic acid. The positive peak around 210 nm and the negative peak around 185 nm in the calculated spectrum were attributable to the nπ* transition of the carboxyl group, with the latter peak also being influenced by the ππ* transition of the carboxyl group; however, the positive peak around 165 nm involved unassignable higher energy transitions. The comparison of the calculated ECD spectra for L‐lactic acid and L‐alanine revealed that the network with loose hydrogen bonding around the COO− and OH groups is responsible for the flexible conformation of hydroxy acids and complicated side‐chain dependence of ECD spectra relative to amino acids. Chirality, 2011. © 2011 Wiley Periodicals, Inc.
Mapping the Catechol Binding Site in Dopamine D1Receptors: Synthesis and Evaluation of Two Parallel Series of Bicyclic Dopamine Analogues
Authors: Bonner Lisa A. , Laban Uros , Chemel Benjamin R. , Juncosa Jose I. , Lill Markus A. , Watts Val J. , Nichols David E. 
Published: April 2011

AbstractA novel class of isochroman dopamine analogues, originally reported by Abbott Laboratories, have >100‐fold selectivity for D1‐like over D2‐like receptors. We synthesized a parallel series of chroman compounds and showed that repositioning the oxygen atom in the heterocyclic ring decreases potency and confers D2‐like receptor selectivity to these compounds. In silico modeling supports the hypothesis that the altered pharmacology for the chroman series is due to potential intramolecular hydrogen bonding between the oxygen in the chroman ring and themeta‐hydroxy group of the catechol moiety. This interaction realigns the catechol hydroxy groups and disrupts key interactions between these ligands and critical serine residues in TM5 of the D1‐like receptors. This hypothesis was tested by the synthesis and pharmacological evaluation of a parallel series of carbocyclic compounds. Our results suggest that if the potential for intramolecular hydrogen bonding is removed, D1‐like receptor potency and selectivity are restored.
Resource allocation for multiuser cognitive OFDM networks with proportional rate constraints
Authors: Wang Shaowei , Huang Fangjiang , Yuan Mindi , Du Sidan 
Published: April 2011

SUMMARYIn this paper we study the resource allocation problem for the multiuser orthogonal frequency division multiplexing (OFDM)‐based cognitive radio (CR) systems with proportional rate constraints. The mutual interference introduced by primary user (PU) and cognitive radio user (also referred to secondary user, SU) makes the optimization problem of CR systems more complex. Moreover, the interference introduced to PUs must be kept under a given threshold. In this paper, the highest achievable rate of each OFDM subchannel is calculated by jointly considering the channel gain and interference level. First, a subchannel is assigned to the SU with the highest achievable rate. The remaining subchannels are always allocated to the SU that suffers the severest unjustness. Second, an efficient bit allocation algorithm is developed to maximize the sum capacity, which is again based on the highest achievable rate of each subchannel. Finally, an adjustment procedure is designed to maintain proportional fairness. Simulation results show that the proposed algorithm maximizes the sum capacity while keeping the proportional rate constraints satisfied. The algorithm exhibits a good tradeoff between sum capacity maximization and proportional fairness. Furthermore, the proposed algorithm has lower complexity compared with other algorithms, rendering it promising for practical applications. Copyright © 2011 John Wiley & Sons, Ltd.
Mobile device integration of a fingerprint biometric remote authentication scheme
Authors: Chen Chin‐Ling , Lee Cheng‐Chi , Hsu Chao‐Yung 
Published: April 2011

SUMMARYVarious user authentication schemes with smart cards have been proposed. Generally, researchers implicitly assume that the contents of a smart card cannot be revealed. However, this is not true. An attacker can analyze the leaked information and obtain the secret values in a smart card. To improve on this drawback, we involve a fingerprint biometric and password to enhance the security level of the remote authentication scheme Our scheme uses only hashing functions to implement a robust authentication with a low computation property. Copyright © 2011 John Wiley & Sons, Ltd.
Male urethral pap smears and peniscopy examination and polymerase chain reaction human papillomavirus correlation
Authors: Lilia Tena‐Suck Martha , Alarcón‐Herrera América , Tirado‐Sánchez Andrés , Rösl Frank , la Vega Horacio Astudillo‐de 
Published: April 2011

AbstractThe aims of this study were to determine HPV in a male population and its correlation with penile gross inspection and urethral pap smears. Fifty male volunteers were included in the study; all of them were sexual partners of women with evidence of HPV‐related cervical diseases. Urethral Pap smear features and polymerase chain reaction (PCR; HPV detection) of urethral samples were correlated. Statistical analyses were conducted to identify variables associated with high and low‐risk HPV types. Mean age of participants was 33.14 ± 1.52 (range, 23–50 years), and the mean age for those with high risk HPV was 32.12 ± 6.66 and 34.08 ± 6.58 for subjects with low‐risk HPV (P = 0.820). Penile gross inspection revealed 19 (38%) cases with no lesions, papules in balanoprepusial furrol/sulcus in 23 (46%) cases, papilla in 23 (46%) cases, urethral lesions in 22 (44%) cases, penile body plaques in 22 (44%) cases, melanoses in 11 (22%) cases, sebaceous cysts on scrotum in 10 (20%) cases, and molting of the glands in 28 (56%) cases. Cytopathologic analysis revealed koilocytes in 24 (48%) cases. Dyskeratosis was observed in 24 (48%) cases. A bacterial background was found in 27 (54%) cases, and inflammatory cells were found in 27 (54%) cases. Twenty‐six (52%) cases showed cytological features suggestive of Gardnerella Vaginalis. Twenty‐four (48%) cases were high‐risk HPV, and 26 (52%) were low‐risk HPV (P = 0.037) as assessed by PCR‐based detection. There was a statistically significant difference between koilocytes and bacterial background with high‐risk human papillomavirus (P = 0.001). Abnormal colposcopy examination detected lesions were sampled for cytology by Pap smears. Diagn. Cytopathol. 2012. © 2011 Wiley Periodicals, Inc.
Diagnostic value of liquid‐based (Liqui‐PREP) preparations and interobserver reproducibility in fine needle aspiration cytology of the nodular thyroid lesions
Authors: Tetikkurt U. S. , Oz Puyan F. , Oz F. , Erdogan N. , Ceylan S. , Yakupoglu A. 
Published: April 2011

AbstractThe aim of this study is to define the diagnostic role of Liqui‐Prep (LP) technique for the diagnosis of thyroid lesions and to assess interobserver variabilities. In all, 98 thyroid FNA (fine needle aspiration) cytology samples from 83 patients for preoperative evaluation of thyroid nodules, prepared by the LP, were examined. The LP slides were independently evaluated by three pathologists and they were classified into the five categories according to the Bethesda system. The histopathologic diagnoses were grouped as follows: benign, follicular neoplasm, and malignant. Agreements between LP and histopathologic diagnoses were investigated using kappa values. Marginal homogenity and kappa tests were used for statistical analysis for the evaluation of the agreement between the pathologists and the interobserver variability of the thyroid aspiration cytology results. The presence of nucleoli, nuclear grooving, overlapping, intranuclear inclusion, and nuclear irregularity were recorded and scored on each case based on LP slide review. Concurrences between LP and the histologic diagnoses for the three pathologists were almost perfect (k = 0.798; k = 0.826; k = 0.880). When the observers were paired there was no significant difference from the diagnostic point of view. Interobserver agreement among the three pathologists was moderate. Initially diagnostic difficulties may occur because of the inadequate experience of the pathologists concerning the evaluation of the cytologic changes associated with this new technique. Liqui‐Prep technique is useful for the cytologic diagnosis of the thyroid nodules. The nuclear irregularity was the most essential feature for the differentiation of malignant lesions from follicular neoplasm by the LP method. Diagn. Cytopathol. 2011; © 2011 Wiley‐Liss, Inc.
Isolated leishmanial lymphadenopathy – A rare type of leishmaniasis in India: A Case Report
Authors: Sharma Mahamaya , Malhotra Ashwini 
Published: April 2011

AbstractA patient presented with isolated, soft to firm, inguinal swelling since childhood clinically thought to be a benign lipomatous lesion. Fine‐needle aspiration of the swelling revealed amastigote form of Leishmania donovani in a background of reactive lymphoid hyperplasia. Excision of the swelling resulted in reversal of positive Aldehyde test. Isolated leishmanial lymphadenopathy in an immunocompetent person, is a rare manifestation of leishmaniasis in India. The possible role of transplacental transmission is discussed. Diagn. Cytopathol. 2012. © 2011 Wiley Periodicals, Inc.
Patterns of papillary thyroid carcinoma cells analyzed in fine‐needle aspiration smears may reveal changes in tumor cell behavior
Authors: Nikonenko Alexander G. , Bozhok Yuriy M. 
Published: April 2011

AbstractFine‐needle aspiration (FNA) cytology is widely used to examine thyroid lesions. However, its diagnostic accuracy is limited by the narrow choice of cytopathologic markers indicative of invasive/metastatic powers of a tumor. The aim of this study was to identify features that may serve as such indicators. We have examined FNA smears of 50 histologically proven papillary thyroid carcinoma (PTC) cases applying computer‐assisted morphometry to assess patterns formed by PTC cells. Cytokeratine (CK) 8 immunocytochemistry was used to verify the epithelial origin of cells under study. All analyzed smears contained blood, histiocyte‐like cells and CK8‐positive follicular cells occurring both as single cells and in monolayer cell sheets. In 60% of cases we revealed cell sheets displaying two distinct cell patterns. The first one (pattern R) consisted of moderately pleomorphic, rather regularly arranged cells having an amphophilic cytoplasm. The second one (pattern I) was formed by highly pleomorphic cells with a basophilic cytoplasm. Patterns R and I were clearly different in cell size and shape as well as in nuclear size and shape. These patterns were never observed within the same cell sheet indicating that they may be formed by different subclones of tumor cells. Thus, it can be concluded that PTC frequently displays two definitely different cell patterns. We think that these patterns have a potential to serve as indicators for early events of an invasive/metastatic process. It remains to be seen whether the simultaneous occurrence of these patterns is a PTC‐specific feature. Diagn. Cytopathol. 2012;40:E55–E61. © 2011 Wiley Periodicals, Inc.
Endoscopic ultrasound‐guided fine needle aspiration (EUS‐FNA) of mediastinal lymph nodes: Experience from region with high prevalence of tuberculosis
Authors: Manucha Varsha , Kaur Gagandeep , Verma Kusum 
Published: April 2011

Utility of EUS‐FNA in diagnosing granulomatous lesions of mediastinum in regions with high prevalence of tuberculosis has not yet been evaluated. In the present study, utility and limitations of EUS‐FNA of mediastinal lesions from a tertiary care center with high prevalence of tuberculosis were studied. All cases where EUS‐FNA had been performed to diagnose mediastinal lymphadenopathy from January 2006 to December 2008 were retrieved from the files of cytopathology laboratory. These were reviewed by the cytopathologist.Two hundred and eighty one EUS‐FNA aspirates from 269 patients were evaluated. Satisfactory aspirates were available in 259 cases. A cytological diagnosis of granulomatous lymphadenitis was rendered in 206 cases. Of these, tuberculosis could be established as an etiology in 76 cases and sarcoidosis in 7 cases only. In remaining 123 cases the etiology of granulomatous lymphadenitis could not be established and clinical correlation was suggested. Malignancies were diagnosed or suspected in 24 and 5 cases, respectively. The study highlights that the dilemma of tuberculosis versus sarcoidosis persists in regions with high prevalence of tuberculosis. However, EUS‐FNA is useful in diagnosing unsuspected malignancies and confirming the presence of granulomatous lymphadenitis. Diagn. Cytopathol. 2013; 41:1019–1022.© 2011 Wiley Periodicals, Inc.
Smear patterns and spectrum of premalignant and malignant cervical epithelial lesions in postmenopausal Indian women: A hospital‐based study
Authors: Ansari Maryem , Mehdi Ghazala , Arif S. H. , Ansari Hena , Khan Tamkin 
Published: April 2011

AbstractCervical cancer is one of the leading causes of morbidity and mortality among women but can be prevented through simple cost‐effective measures, such as creating awareness, and regular screening with the Pap smear, both in the premenopausal and postmenopausal age group. This study was carried out to study the cervical smear patterns and type of cervical epithelial lesions in a group of postmenopausal Indian females and the relationship with clinical profile of patients. Pap smears were taken from 320 postmenopausal Indian females and meticulously screened. Lesions were classified according to type of postmenopausal pattern. 120 smears showed varying degrees of premalignant and malignant changes, which were classified using the Bethesda system. The findings were correlated with duration of menopause, parity, and duration of sexual activity and significance was derived. Histopathological correlation was conducted in those cases where biopsies were available. It was found that as the age of the patients increased, the incidence of low‐grade and high‐grade squamous intraepithelial lesions and carcinoma also increased with the relationship being statistically significant. The occurrence of these lesions also showed an association with increasing parity and period of sexual activity. Thus, it can be concluded that it is important to create widespread awareness about the necessity of regular screening, including the postmenopausal period. Conventional cytology or the Pap smear is a cost‐effective and efficient method for screening of patients but requires training and experience to minimize errors. It is suitable for developing regions where costlier techniques are not in routine use. Diagn. Cytopathol. 2012. © 2011 Wiley Periodicals, Inc.
Long‐range signaling systems controlling glial migration in the Drosophila eye
Authors: Yuva‐Aydemir Yeliz , Klämbt Christian 
Published: April 2011

AbstractThe Drosophila compound eye comprises about 750 individual ommatidia arranged into an almost crystalline array. The eye is not needed for viability and thus served as a favorite model organ to decipher many signaling systems controlling diverse aspects such as cell fate allocation or cell‐cycle control. Here, we review that the Drosophila eye can also serve to study the interaction between neurons and glial cells. In the Drosophila eye, all glial cells originate from the brain lobes and need to migrate onto the larval eye disc as neurogenesis is initiated during the third instar stage. Although we do have a relatively good understanding of the sequential progression of neurogenesis in the eye disc, we are still at the beginning in our dissection of the molecular pathways orchestrating the coordinated development of neurons and glial cells. © 2011 Wiley Periodicals, Inc. Develop Neurobiol 71: 1310‐1316, 2011
Visual circuit assembly in Drosophila
Authors: Melnattur Krishna V. , Lee Chi‐Hon 
Published: April 2011

AbstractBoth insect and vertebrate visual circuits are organized into orderly arrays of columnar and layered synaptic units that correspond to the array of photoreceptors in the eye. Recent genetic studies in Drosophila have yielded insights into the molecular and cellular mechanisms that pattern the layers and columns and establish specific connections within the synaptic units. A sequence of inductive events and complex cellular interactions coordinates the assembly of visual circuits. Photoreceptor‐derived ligands, such as hedgehog and Jelly–Belly, induce target development and expression of specific adhesion molecules, which in turn serve as guidance cues for photoreceptor axons. Afferents are directed to specific layers by adhesive afferent–target interactions mediated by leucine‐rich repeat proteins and cadherins, which are restricted spatially and/or modulated dynamically. Afferents are restricted to their topographically appropriate columns by repulsive interactions between afferents and by autocrine activin signaling. Finally, Dscam‐mediated repulsive interactions between target neuron dendrites ensure appropriate combinations of postsynaptic elements at synapses. Essentially, all these Drosophila molecules have vertebrate homologs, some of which are known to carry out analogous functions. Thus, the studies of Drosophila visual circuit development would shed light on neural circuit assembly in general. © 2011 Wiley Periodicals, Inc.* Develop Neurobiol 71: 1286‐1296, 2011
Guidelines for European workplace drug testing in oral fluid
Authors: Cooper Gail , Moore Christine , George Claire , Pichini Simona 
Published: April 2011

AbstractOver the past decade, oral fluid has established itself as a robust testing matrix for monitoring drug use or misuse. Commercially available collection devices provide opportunities to collect and test oral fluid by the roadside and near‐patient testing with both clinical and criminal justice applications. One of the main advantages of oral fluid relates to the collection of the matrix which is non‐invasive, simple, and can be carried out under direct observation making it ideal for workplace drug testing.Laboratories offering legally defensible oral fluid workplace drug testing must adhere to national and international quality standards (ISO/IEC 17025); however, these standards do not address issues specific to oral fluid testing. The European Workplace Drug Testing Society (EWDTS) recognizes the importance of providing best practice guidelines to organizations offering testing and those choosing to use oral fluid drug testing to test their employees.The aim of this paper is to present the EWDTS guidelines for oral fluid workplace drug testing. Copyright © 2011 John Wiley & Sons, Ltd.
Dotofide, a Guanidine‐Interrupted Terpenoid from the Marine Slug Doto pinnatifida (Gastropoda, Nudibranchia)
Authors: Putz Annika , Kehraus Stefan , Díaz‐Agras Guillermo , Wägele Heike , König Gabriele M. 
Published: April 2011

AbstractAn unusual natural product (dotofide, 1), in which the terpenoid skeleton is interrupted by a guanidine moiety was obtained from the marine slug Doto pinnatifida. The absolute configuration of compound 1 was deduced by ozonolysis and subsequent CD spectroscopy. D. pinnatifida subsists on the hydrozoan Nemertesia antennina (Cnidaria), which however does not contain dotofide, suggesting that the snail is able to perform the biosynthesis of the metabolite by itself. D. pinnatifida is grouped into the chemically hardly investigated taxon Cladobranchia (Opisthobranchia, Gastropoda). All members of this taxon completely lack a shell and are thought to employ toxic secondary metabolites or alternatively cnidocysts sequestered from their cnidarian prey organism as defence strategy.