bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical study on the impact of the COVID‐19 pandemic on mandibular fractures at a regional core hospital for emergency and critical care medicine in Tokyo, Japan
Authors: Kitano Erina , Abe Shigehiro , Shinoda Kenta , Takayama Hiromasa , Fujiwara Yuusuke , Kawano Tempei , Masaoka Yoh , Nagai Tomoya , Aizawa Sohichi , Kitano Hisataka 
Published: April 2024

AbstractAimMaxillofacial trauma is routinely encountered in oral and maxillofacial surgery, especially in cases of mandibular fractures; however, no clinical studies currently exist on the effects of the coronavirus disease (COVID‐19) pandemic on mandibular fractures in Japan. This study aimed to analyze the impact of COVID‐19 on mandibular fractures in Tokyo, Japan.MethodsThis retrospective study included patients with mandibular fractures who visited the Department of Oral Surgery at our hospital between January 2014 and December 2022. We conducted a clinico‐statistical study of patients who presented with mandibular fractures before and during the COVID‐19 pandemic.ResultsThe monthly average number of patients presenting with mandibular fractures decreased significantly in the first to third waves of the COVID‐19 pandemic (p = 0.0191) but increased during the fourth to seventh waves. The median patients' age was 46 and 59 years before and during the COVID‐19 pandemic, respectively, and this difference was significant (p = 0.0275). No significant differences were observed in sex, site of injury, cause, or treatment. However, the day of presentation (same day as injury or 1 day later) differed significantly (p = 0.0091) before and during the COVID‐19 pandemic. A significant decrease in concomitant trauma was observed during the COVID‐19 pandemic compared with the prepandemic period (p = 0.0054).ConclusionsThis study is the first to report the impact of COVID‐19 on mandibular fractures in Japan. The findings differ from those obtained from studies in other countries and provide a good basis for understanding COVID‐19 and preparing for future pandemics.
Expanding access to identification cards and social programs: Experimental evidence from Panamá
Authors: Reyes Ángela María , Roseth Benjamin , Vera‐Cossio Diego 
Published: April 2024

AbstractWe experimentally analyze the effects of an intervention to induce the renewal of identification cards on access to a government social program in Panamá. On‐time renewals and access to government transfers increased by 10 and 3.6 percentage points, respectively. Simple reminders about expiration dates generated larger effects than also enabling individuals to renew their documents through an online platform, which users struggled to use despite its being designed to simplify the process. The results suggest that increasing access to identity documentation can reduce exclusion errors in social programs and that simply granting access to e‐government platforms may not necessarily improve public service delivery.
Survival outcomes in pediatric patients with metastatic Ewing sarcoma who achieve a rapid complete response of pulmonary metastases
Authors: Reiter Audra J. , Huang Lynn , Craig Brian T. , Davidoff Andrew M. , Talbot Lindsay J. , Coggins Jordan , Smith Jasmine , Aldrink Jennifer H. , Bergus Katherine C. , MacArthur Taleen A. , Polites Stephanie F. , Boehmer Chloe , Brungardt Joseph , Malek Marcus M. , Rinehardt Hannah N. , Kastenberg Zachary J. , Arkin Cameron M. , Gourmel Antoine , Piche Nelson , Wallace Marshall , Liang Jiancong , Lovvorn Harold N. , Petroze Robin T. , Gillies Gwendolyn , Marquart John P. , Becktell Kerri , Le Hau D. , Favela Juan , Rich Barrie S. , Glick Richard D. , Seemann Natashia M. , Davidson Jacob , Wilson Claire A. , Roach Jonathan , Brown Erin G. , Doyle Kathleen E. , Coakley Brian A. , Emengo Pamela , Merola Pamela , Grant Christa N. , Tirumani Anuritha , Tracy Elisabeth T. , Moya‐Mendez Mary E. , Dasgupta Roshni , Lautz Timothy B. ,   Pediatric Surgical Oncology Research Collaborative
Published: April 2024

AbstractPurposeOur objectives were to compare overall survival (OS) and pulmonary relapse between patients with metastatic Ewing sarcoma (EWS) at diagnosis who achieve rapid complete response (RCR) and those with residual pulmonary nodules after induction chemotherapy (non‐RCR).Patients and methodsThis retrospective cohort study included children under 20 years with metastatic EWS treated from 2007 to 2020 at 19 institutions in the Pediatric Surgical Oncology Research Collaborative. Chi‐square tests were conducted for differences among groups. Kaplan–Meier curves were generated for OS and pulmonary relapse.ResultsAmong 148 patients with metastatic EWS at diagnosis, 61 (41.2%) achieved RCR. Five‐year OS was 71.2% for patients who achieved RCR, and 50.2% for those without RCR (p = .04), and in multivariable regression among patients with isolated pulmonary metastases, RCR (hazards ratio [HR] 0.42; 95% confidence interval [CI]: 0.17–0.99) and whole lung irradiation (WLI) (HR 0.35; 95% CI: 0.16–0.77) were associated with improved survival. Pulmonary relapse occurred in 57 (37%) patients, including 18 (29%) in the RCR and 36 (41%) in the non‐RCR groups (p = .14). Five‐year pulmonary relapse rates did not significantly differ based on RCR (33.0%) versus non‐RCR (47.0%, p = .13), or WLI (38.8%) versus no WLI (46.0%, p = .32).DiscussionPatients with EWS who had isolated pulmonary metastases at diagnosis had improved OS if they achieved RCR and received WLI, despite having no significant differences in rates of pulmonary relapse.
Prognostic value of hemogram parameters in osteosarcoma: The French OS2006 experience
Authors: Bastard Paul , Cozic Nathalie , Brion Régis , Gaspar Nathalie , Piperno‐Neumann Sophie , Cordero Camille , Leculée‐Thébaud Estelle , Gomez‐Mascard Anne , Rédini Françoise , Marchais Antonin , Ikonomova Raina , Cleirec Morgane , Laurence Valérie , Rigaud Charlotte , Abbas Rachid , Verrecchia Franck , Brugières Laurence , Minard‐Colin Véronique 
Published: April 2024

AbstractBackgroundPrevious studies have shown that neutrophil‐to‐lymphocyte (NLR) ratio at diagnosis and early lymphocytes recovery on doxorubicin‐based chemotherapy, may impact the outcome in patients with osteosarcoma (OST). This study aimed to evaluate the prognostic value of hemogram parameters in patients with OST treated with high‐dose methotrexate and etoposide/ifosfamide (M‐EI) chemotherapy.Materials and methodsWe retrospectively analyzed the prognostic value of various hemogram parameters at diagnosis and during therapy in a large consecutive cohort of patients with OST included in the French OS2006 trial and treated with M‐EI chemotherapy.ResultsA total of 164 patients were analyzed. The median age was 14.7 years (interquartile range [IQR]: 11.7–17). Median follow‐up was 5.6 years (IQR: 3.3–7.7 years). Three‐year event‐free survival (EFS) and overall survival (OS) were 71.5% (95% confidence interval [CI]: 64%–78%) and 86.4% (95% CI: 80%–91%), respectively. In univariate analysis, blood count parameters at diagnosis and early lymphocyte recovery at Day 14 were not found prognostic of survival outcomes. By contrast, an increase of NLR ratio at Day 1 of the first EI chemotherapy (NLR‐W4) was associated with reduced OS in univariate (p = .0044) and multivariate analysis (hazards ratio [HR] = 1.3, 95% CI: 1.1–1.5; p = .002), although not with EFS. After adjustment on histological response and metastatic status, an increase of the ratio NLR‐W4 of 1 was associated with an increased risk of death of 30%.ConclusionsWe identified NLR‐W4 as a potential early biomarker for survival in patients with OST treated with M‐EI chemotherapy. Further studies are required to confirm the prognostic value of NLR and better identify immune mechanisms involved in disease surveillance.
Invasive fungal disease in children with solid tumors: An Australian multicenter 10‐year review
Authors: Jain Neha , Ryan Anne L. , Haeusler Gabrielle M. , McMullan Brendan J. , Moore Andrew S. , Bartlett Adam W. , Blyth Christopher C. , Kotecha Rishi S. , Yeoh Daniel K. , Clark Julia E. 
Published: April 2024

AbstractInvasive fungal disease (IFD) occurs less frequently during treatment for solid compared to hematological malignancies in children, and risk groups are poorly defined. Retrospective national multicenter cohort data (2004–2013) were analyzed to document prevalence, clinical characteristics, and microbiology of IFD. Amongst 2067 children treated for solid malignancy, IFD prevalence was 1.9% overall and 1.4% for proven/probable IFD. Of all IFD episodes, 42.5% occurred in patients with neuroblastoma (prevalence 7.0%). Candida species comprised 54.8% of implicated pathogens in proven/probable IFD. In children with solid tumors, IFD is rare, and predominantly caused by yeasts.Routine prophylaxis may not be warranted.
Developmental and adaptive functioning of very young children with solid tumors and brain tumors
Authors: Fitzpatrick Sequoya , Jacola Lisa M. , Harman Jennifer L. , Willard Victoria W. 
Published: April 2024

AbstractPurposeInfancy/toddlerhood is a period of rapid development. All infants/toddlers (0–36 months‐of‐age) undergoing cancer‐directed treatment at one hospital are offered developmental assessments and related services. Yet, literature comparing development of infants/toddlers with brain tumors to those with non‐CNS solid tumors is sparse.Design and methodsDevelopmental assessment data were abstracted from electronic health records of infants/toddlers undergoing treatment for a brain tumor (n = 36; mean age = 21.83 ± 9.96 months) or a solid tumor (n = 40; mean age = 17.35 ± 8.50). Z‐scores compared obtained data with age expectations. Chi‐square analyses assessed whether a greater proportion of participants scored within the clinical range than normative expectations. Multivariate analysis of variance and chi‐square analyses compared developmental outcomes between groups.ResultsCompared with age expectations, the overall group demonstrated significantly less well‐developed skills. Infants/toddlers with solid tumors demonstrated clinical deficits at rates higher than expected for most domains; the rate of impairment for the solid tumor group did not differ significantly from that of the brain tumor group across most subtests.ConclusionsLike young patients with brain tumors, the developmental functioning of infants/toddlers with solid tumors should be studied across time to determine the trajectory of functioning for these young patients and to inform future developmental intervention studies.Practice implicationsInfants/toddlers with a malignant solid tumor may be at increased risk for delayed development. These very young patients would likely benefit from developmental assessment, early intervention services during and after treatment, and ongoing monitoring of development across time.
Informing research on generative artificial intelligence from a language and literacy perspective: A meta‐synthesis of studies in science education
Authors: Tang Kok‐Sing 
Published: April 2024

AbstractResearch in languages and literacies in science education (LLSE) has developed substantial theoretical and pedagogical insights into how students learn science through language, discourse, and multimodal representations. At the same time, language is central to the functioning of generative artificial intelligence (GenAI). On this common basis concerning the role of language, this paper explores how foundational ideas from LLSE studies can inform the use of GenAI in science education. A bibliometric analysis of 412 journal articles from Web of Science provided the initial step to identify major themes and relationships in the LLSE literature. The analysis revealed four clusters of research in LLSE: reading and writing scientific text, science discourse and interaction, multilingual science classroom, and multimodality and representations. Each cluster was further analyzed through close reading of selected articles to identify and connect key constructs to the potential use of GenAI. These constructs include the interactive‐constructive reading model, text genre, reading‐writing integration, dialogic interaction, critical questioning, argumentation, translanguaging, hybridity, thematic pattern, modal affordance, and transduction. From these ideas and connections, the paper recommends several pedagogical principles for science educators to guide the use of GenAI. It concludes that LLSE research offers valuable insights for researchers and teachers to investigate and design the use of GenAI in science education. In turn, the impending use of GenAI also calls for a rethinking of literacy that will shape future research in LLSE.
Multimode Luminescence with Temperature and Energy Level Synergistic Dependence in Rare Earth Halide DPs for Advanced Multifunctional Applications
Authors: Lian Bo , Hou Haowen , Lin Fangping , Luo Binbin , Pan Daocheng , Zou Bingsuo , Zeng Ruosheng 
Published: April 2024

AbstractRare‐earth halide double perovskites (DPs) have attracted extensive attention due to their excellent optoelectronic performance. However, the correlation between luminescence performance, crystal structure, and temperature, as well as the inherent energy transfer mechanism, is not well understood. Herein, Lanthanide ions (Ln3+: Nd3+ or Dy3+) as the co‐dopants are incorporated into Sb3+ doped Cs2NaYbCl6 DPs to construct energy transfer (ET) models to reveal the effects of temperature and energy levels of rare earth on luminescence and ET. The different excited state structures of Sb3+‐Ln3+ doped Cs2NaYbCl6 DPs at different temperatures and relative positions of energy levels of rare earth synergistically determine the physical processes of luminescence. These multi‐mode luminescent materials exhibit good performance in anti‐counterfeiting, NIR imaging, and temperature sensing. This work provides new physical insights into the effects of temperature and energy levels of rare earth on the energy transfer mechanism and related photophysical process.
MXene Crosslinked Hydrogels with Low Hysteresis Conferred by Sliding Tangle Island Strategy
Authors: Zou Jian , Jing Xin , Li Shitao , Feng Peiyong , Chen Yi , Liu Yuejun 
Published: April 2024

AbstractSingle‐network hydrogels are often too fragile to withstand mechanical loading, whereas double‐network hydrogels typically exhibit significant hysteresis during cyclic stretching‐releasing process due to the presence of a sacrificial network. Consequently, it is a considerable challenge for designing hydrogels that are both low in hysteresis and high in toughness for applications requiring dynamic mechanical loads. Herein, the study introduced a novel “sliding tangle island” strategy for creating tough and low‐hysteresis hydrogels, which are prepared through in situ polymerization of highly concentrated acrylamides (AM) to form numerous entanglements within the MXene spacing without any chemical crosslinker. The MXene entangled with long polyacrylamide (PAM) chains to form tangle island that served as a relay station to transmit stress to neighboring molecular chains. This mechanism helps alleviate stress concentration and enhances energy dissipation efficiency, thereby reducing mechanical hysteresis. The resulting hydrogel exhibited exceptional properties, including high stretchability (≈900%), low hysteresis (less than 7%), high toughness (1.34 MJ m−3), and excellent sensing performance to rival the commercial hydrogel electrode. Therefore, this work sheds light on feasible design of energy dissipation structure to reduce the hysteresis of the composite hydrogels.
Prussian Blue Analogues for Sodium‐Ion Battery Cathodes: A Review of Mechanistic Insights, Current Challenges, and Future Pathways
Authors: Xiao Yang , Xiao Jun , Zhao Hangkai , Li Jiayi , Zhang Guilai , Zhang Dingyi , Guo Xin , Gao Hong , Wang Yong , Chen Jun , Wang Guoxiu , Liu Hao 
Published: April 2024

AbstractPrussian blue analogues (PBAs) have emerged as highly promising cathode materials for sodium‐ion batteries (SIBs) due to their affordability, facile synthesis, porous framework, and high theoretical capacity. Despite their considerable potential, practical applications of PBAs face significant challenges that limit their performance. This review offers a comprehensive retrospective analysis of PBAs' development history as cathode materials, delving into their reaction mechanisms, including charge compensation and ion diffusion mechanisms. Furthermore, to overcome these challenges, a range of improvement strategies are proposed, encompassing modifications in synthesis techniques and enhancements in structural stability. Finally, the commercial viability of PBAs is examined, alongside discussions on advanced synthesis methods and existing concerns regarding cost and safety, aiming to foster ongoing advancements of PBAs for practical SIBs.
Self‐Assembled Molecular Fibers Aligned by Compression in Water
Authors: Mizoshita Norihiro , Yamada Yuri , Masuoka Yumi 
Published: April 2024

AbstractMolecular self‐assembly has attracted much attention as a potential approach for fabricating nanostructured functional materials. To date, energy‐efficient fabrication of nano‐objects such as nanofibers, nanorings, and nanotubes is achieved using well‐designed self‐assembling molecules. However, the application of molecular self‐assembly to industrial manufacturing processes remains challenging because regulating the positions and directions of self‐assembled products is difficult. Non‐covalent molecular assemblies are also too fragile to allow mechanical handling. The present work demonstrates the macroscopic alignment of self‐assembled molecular fibers using compression. Specifically, the macroscopic bundling of self‐assembled nanofibers is achieved following dispersion in water. These fiber bundles can also be chemically crosslinked without drastic changes in morphology via trialkoxysilyl groups. Subsequently, vertically oriented porous membranes can be produced rapidly by slicing the bundles. This technique is expected to be applicable to various functional self‐assembled fibers and can lead to the development of innovative methods of producing anisotropic nanostructured materials.
Hypoelliptic functional inequalities
Authors: Ruzhansky Michael , Yessirkegenov Nurgissa 
Published: April 2024

AbstractIn this paper we derive a variety of functional inequalities for general homogeneous invariant hypoelliptic differential operators on nilpotent Lie groups. The obtained inequalities include Hardy, Sobolev, Rellich, Hardy–Littllewood–Sobolev, Gagliardo–Nirenberg, Caffarelli–Kohn–Nirenberg and Heisenberg–Pauli–Weyl type uncertainty inequalities. Some of these estimates have been known in the case of the sub-Laplacians, however, for more general hypoelliptic operators almost all of them appear to be new as no approaches for obtaining such estimates have been available. The approach developed in this paper relies on establishing integral versions of Hardy inequalities on homogeneous Lie groups, for which we also find necessary and sufficient conditions for the weights for such inequalities to be true. Consequently, we link such integral Hardy inequalities to different hypoelliptic inequalities by using the Riesz and Bessel kernels associated to the described hypoelliptic operators.
Quantitative assessment of background parenchymal enhancement is associated with lifetime breast cancer risk in screening MRI
Authors: Yan Ran , Murakami Wakana , Mortazavi Shabnam , Yu Tiffany , Chu Fang-I. , Lee-Felker Stephanie , Sung Kyunghyun 
Published: April 2024

Abstract
Objectives
To compare the quantitative background parenchymal enhancement (BPE) in women with different lifetime risks and BRCA mutation status of breast cancer using screening MRI.

Materials and methods
This study included screening MRI of 535 women divided into three groups based on lifetime risk: nonhigh-risk women, high-risk women without BRCA mutation, and BRCA1/2 mutation carriers. Six quantitative BPE measurements, including percent enhancement (PE) and signal enhancement ratio (SER), were calculated on DCE-MRI after segmentation of the whole breast and fibroglandular tissue (FGT). The associations between lifetime risk factors and BPE were analyzed via linear regression analysis. We adjusted for risk factors influencing BPE using propensity score matching (PSM) and compared the BPE between different groups. A two-sided Mann–Whitney U-test was used to compare the BPE with a threshold of 0.1 for multiple testing issue-adjusted p values.

Results
Age, BMI, menopausal status, and FGT level were significantly correlated with quantitative BPE based on the univariate and multivariable linear regression analyses. After adjusting for age, BMI, menopausal status, hormonal treatment history, and FGT level using PSM, significant differences were observed between high-risk non-BRCA and BRCA groups in PEFGT (11.5 vs. 8.0%, adjusted p = 0.018) and SERFGT (7.2 vs. 9.3%, adjusted p = 0.066).

Conclusion
Quantitative BPE varies in women with different lifetime breast cancer risks and BRCA mutation status. These differences may be due to the influence of multiple lifetime risk factors. Quantitative BPE differences remained between groups with and without BRCA mutations after adjusting for known risk factors associated with BPE.

Clinical relevance statement
BRCA germline mutations may be associated with quantitative background parenchymal enhancement, excluding the effects of known confounding factors. This finding can provide potential insights into the cancer pathophysiological mechanisms behind lifetime risk models.

Key Points

Expanding understanding of breast cancer pathophysiology allows for improved risk stratification and optimized screening protocols.

Quantitative BPE is significantly associated with lifetime risk factors and differs between BRCA mutation carriers and noncarriers.

This research offers a possible understanding of the physiological mechanisms underlying quantitative BPE and BRCA germline mutations.
The role of agricultural biomass in supply chain decarbonization
Authors: Lyu Ruxia , Arisian Sobhan , Li Zhitang , Taskhiri Mohammad Sadegh , Mavi Reza Kiani 
Published: April 2024

AbstractTo achieve supply chain decarbonization, environmentally conscious manufacturers are transforming their energy infrastructure. While certain manufacturers are adopting a pure bioenergy strategy in their production processes, others are opting for a hybrid energy approach that combines traditional energy with bioenergy. This choice is often influenced by limitations in land capacity and the developmental stage of biomass conversion technologies. This paper introduces a game-theoretic model that explores the optimal approach to achieving supply chain decarbonization by strategically selecting energy portfolios. Our findings reveal that in scenarios where the market size is small, manufacturers tend to adopt a hybrid energy strategy, particularly when the average yield of biomass is low. However, as the biomass yield increases, manufacturers lean towards a hybrid (or pure) bioenergy strategy in smaller (or larger) markets. In larger markets, the manufacturer’s energy strategies become more complex and are influenced by various factors. Our results emphasize that farmers should base their planting decisions on considerations such as available land, initial investment, and agricultural biomass yield. This paper urges manufacturers to effectively navigate the complexities of the carbon tax policy and make informed decisions that promote a sustainable energy strategy. By utilizing technological advancements, governments and manufacturers can collect and analyze data on factors such as market size, biomass yield, and carbon tax policy, ultimately working towards a more efficient, productive, and environmentally sustainable future.