bluuebunny/crossref_metadata_2025_split huggingface dataset:
Perioperative Medication Management (POMM) Pilot: Integrating a Community-Based Medication History (MedsCheck) into Medication Reconciliation for Elective Orthopedic Surgery Inpatients
Authors: Leung Valerie , Mach Kieu , Charlesworth Emily , Hicks Sandy , Kizemchuk Kristine , Stumpo Carmine 
Published: March 2010

Background: Medication safety along the continuum of care is dependent on the quality of medication information at each point of transfer. The purpose of our study was to assess the impact of integrating a community-based medication history (MedsCheck) into perioperative medication reconciliation for elective orthopedic surgery patients by assessing postoperative unintentional medication discrepancies. Secondary objectives were to evaluate community pharmacist participation and patient satisfaction. Methods: Patients scheduled for elective hip or knee surgery between April and September 2008 were identified as the study population. Patients and community pharmacies were contacted to coordinate the MedsCheck prior to the pre-admission clinic visit. At the visit, the Meds Check document was used to prepare a best possible medication history, which was documented in the patient chart. Medications were reconciled postoperatively. Participants were surveyed for feedback on the process. Results: Eighty-two patients were included in the study. A MedsCheck was completed for 73.8% (31/42) of eligible patients who were contacted prior to their pre-admission clinic visit. The average number of medications per patient was 8.4. The percentage of patients with at least 1 unintentional medication discrepancy decreased from 68.4% (13/19) to 47.6% (39/82) post-intervention. Total unintentional medication discrepancies decreased from 25.6% to 10.6%. Discussion: Integrating MedsCheck into the perioperative medication reconciliation process resulted in positive outcomes. The main challenge was coordination of the MedsCheck service prior to the patient's pre-admission clinic visit. Conclusion: Integrating MedsCheck into routine perioperative care for orthopedic patients is a feasible way to facilitate pharmacist medication reconciliation and increase patient satisfaction.
Chronique de jurisprudence
Authors: Abdelgawad Walid , Jourdain-Fortier Clotilde , Moine-Dupuis Isabelle 
Published: March 2010

Énième et ultime ( ?) décision dans l’affaire CE-Hormones : l’Organe d’appel de l’ORD refuse de mettre un terme aux sanctions commerciales pratiquées par les États-Unis et le Canada à l’encontre des Communautés européennes, lesquelles continuent de refuser l’accès à leur marché à la viande de bœuf traitée aux hormones, au nom de la protection de la santé publique. Pourtant, le rapport rendu précédemment par le groupe spécial, qui aboutissait à une conclusion identique, est infirmé sur de nombreux points par l’Organe d’appel (notamment sur la question de l’évaluation scientifique et du principe de précaution), révélant une meilleure prise en compte des objectifs non marchands par l’Accord SPS. L’Organe d’appel toujours, après le groupe spécial saisi de l’affaire des pièces automobiles, condamne la Chine pour avoir accordé, par son système douanier, un traitement préférentiel aux pièces nationales par rapport aux pièces importées, à savoir l’assimilation des kits de pièces automobiles aux véhicules complets, d’où une taxation plus élevée que pour les pièces chinoises. Il s’agit de la première condamnation de la Chine par l’ORD. Une deuxième condamnation s’est ensuivie peu après l’adhésion de la Chine à l’OMC, impliquant de sa part une remise en cause, encore incomplète, de sa situation d’ « empire » de la contrefaçon. La Chine se voit ainsi reprocher de ne pas accorder le bénéfice des droits d’auteur aux œuvres dont elle n’autorise pas la diffusion ; elle est également condamnée pour une partie de sa législation qui ne garantit pas la mise hors circuits commerciaux des marchandises contrefaites.
The ICL1 and MLS1 Genes, Integral to the Glyoxylate Cycle, are Essential and Specific for Caloric Restriction‐Mediated Extension of Lifespan in Budding Yeast
Authors: Kwon Young‐Yon , Lee Han‐Jun , Lee Myung‐Jin , Lee Young‐Sam , Lee Cheol‐Koo 
Published: May 2024

AbstractThe regulation of complex energy metabolism is intricately linked to cellular energy demands. Caloric restriction (CR) plays a pivotal role in modulating the expression of genes associated with key metabolic pathways, including glycolysis, the tricarboxylic acid (TCA) cycle, and the glyoxylate cycle. In this study, the chronological lifespan (CLS) of 35 viable single‐gene deletion mutants under both non‐restricted and CR conditions, focusing on genes related to these metabolic pathways is evaluated. CR is found to increase CLS predominantly in mutants associated with the glycolysis and TCA cycle. However, this beneficial effect of CR is not observed in mutants of the glyoxylate cycle, particularly those lacking genes for critical enzymes like isocitrate lyase 1 (icl1Δ) and malate synthase 1 (mls1Δ). This analysis revealed an increase in isocitrate lyase activity, a key enzyme of the glyoxylate cycle, under CR, unlike the activity of isocitrate dehydrogenase, which remains unchanged and is specific to the TCA cycle. Interestingly, rapamycin, a compound known for extending lifespan, does not increase the activity of the glyoxylate cycle enzyme. This suggests that CR affects lifespan through a distinct metabolic mechanism.
Dual Dynamic Crosslinked Hydrogel Patch Embodied with Anti‐Bacterial and Macrophage Regulatory Properties for Synergistic Prevention of Peritendinous Adhesion
Authors: Yao Xuan , Hu Wenhui , Li Yuheng , Li Jianmei , Kang Fei , Zhang Jing , Dong Shiwu 
Published: May 2024

AbstractThe occurrence of peritendinous adhesion, which hampers the quality and function of the healed tendon, is strongly linked to oxidative stress, inflammatory, and infection that occur after surgery. Tendon damage and repair provide a considerable obstacle for regenerative medicine owing to the absence of patches that possess comprehensive functionality, including self‐healing capacity, anti‐inflammatory and anti‐bacterial properties, as well as tissue repair guidance. A dual dynamic crosslinked network is created by coordination bonds between catechol groups in protocatechuic aldehyde (PA) and Fe3+, as well as a dynamic Schiff base reaction between amino groups in hyaluronic acid‐adipic acid dihydrazide (HA‐ADH) and aldehyde groups in PA. The HA‐ADH@PA/Fe hydrogel exhibits self‐healing ability, tissue adhesion, anti‐bacterial activity, regulation of macrophage polarization via the NF‐κB signaling, oxidative stress elimination, and anti‐inflammation. In addition, a dual‐layer Janus patch is created, taking inspiration from the anatomy and disease progression of tendon adhesion. The inner layer of the patch, which is in direct contact with the operated tendon, is a multifunctional HA‐ADH@PA/Fe hydrogel, encircled further by a poly(ɛ‐caprolactone) (PCL) electrospinning membrane outer layer facing the surrounding tissue. The PCL@HA‐ADH@PA/Fe hydrogel patch reduced tendon adhesion and supported tissue regeneration by stimulating macrophages polarization into an anti‐inflammatory phenotype and resolving both local and systemic inflammation. This research showcased the PCL@HA‐ADH@PA/Fe hydrogel patch as an alternative therapeutic method for preventing the development of adhesions around tendons.
Materials and Designs for Extremely Efficient Encapsulation of Soft, Biodegradable Electronics
Authors: Ko Gwan‐Jin , Kang Heeseok , Han Won Bae , Dutta Ankan , Shin Jeong‐Woong , Jang Tae‐Min , Han Sungkeun , Lim Jun Hyeon , Eom Chan‐Hwi , Choi So Jeong , Ryu Yelynn , Yeo Woon‐Hong , Cheng Huanyu , Hwang Suk‐Won 
Published: May 2024

AbstractEffective encapsulation is essential for reliable operation of bio‐integrated electronics, particularly those containing dissolvable elements, under humid environments for desired periods of time; however, conventional inorganic or organic encapsulants often suffer from tissue‐incompatible mechanical rigidity and insufficient water‐barrier performance. Here, a mechanically resilient and efficient encapsulation strategy is proposed that can exceed a functional lifetime of state‐of‐the‐art soft encapsulations by several tens of magnitudes. The exceptional protection arises from the high aspect ratio of dissolvable yet impermeable inorganic fillers embedded within biodegradable polymers, which significantly extend the diffusion length of biofluids or water components. Theoretical modeling and experimental analysis elucidate the effects of types, shapes, and concentrations of the fillers on encapsulation performance, as well as mechanical/physical properties. The operation of electronic components under aqueous solutions for prolonged periods demonstrates the practical feasibility of the encapsulation approach for versatile types of soft, biodegradable electronics.
Proton Self‐Limiting Effect of Solid Acids Boosts Electrochemical Performance of Zinc‐ion Batteries
Authors: Chen Mengting , Liu Wenbao , Ren Danyang , An Yunlin , Shu Chang , Zhang Shengguang , Liang Wenjun , Sun Jianchao , Kang Feiyu , Jiang Fuyi 
Published: May 2024

AbstractAt present, aqueous rechargeable Zn–MnO2 batteries have attracted widespread attention as green potential application for renewable energy storage devices. MnO2 cathode has great potential for application, but its proton reaction results in side reactions of cathode, electrolyte consumption, and dramatic pH value changes, suffering from capacity degradation. To address the issues caused by proton deficit, a proton–limited domain strategy is proposed by integrating solid acids (Sulfonic acid type polystyrene–divinylbenzene, SATP) with proton exchange reactions into MnO2. SATP can act as a new proton source increasing the amount of H+ and reducing the generation of zinc hydroxide sulfate, by–product of proton at the cathode interface, via proton exchange reactions of ‐HSO3– group. As a result, Zn–MnO2/SATP battery delivered with excellent rate performance (218.4 mAh g–1 at 2 A g–1) and high cycling stability (the retained capacity of 115.8 mAh g–1 after 500 cycles at a current density of 1 A g–1. This work provides an innovative strategy for high performance aqueous Zn–MnO2 batteries.
Advanced Immunomodulatory Biomaterials for Therapeutic Applications
Authors: Park Ji‐Eun , Kim Dong‐Hwee 
Published: May 2024

AbstractThe multifaceted biological defense system modulating complex immune responses against pathogens and foreign materials plays a critical role in tissue homeostasis and disease progression. Recently developed biomaterials that can specifically regulate immune responses, nanoparticles, graphene, and functional hydrogels have contributed to the advancement of tissue engineering as well as disease treatment. The interaction between innate and adaptive immunity, collectively determining immune responses, can be regulated by mechanobiological recognition and adaptation of immune cells to the extracellular microenvironment. Therefore, applying immunomodulation to tissue regeneration and cancer therapy involves manipulating the properties of biomaterials by tailoring their composition in the context of the immune system. This review provides a comprehensive overview of how the physicochemical attributes of biomaterials determine immune responses, focusing on the physical properties that influence innate and adaptive immunity. This review also underscores the critical aspect of biomaterial‐based immune engineering for the development of novel therapeutics and emphasizes the importance of understanding the biomaterials‐mediated immunological mechanisms and their role in modulating the immune system.
Bioprinting‐Assisted Tissue Assembly for Structural and Functional Modulation of Engineered Heart Tissue Mimicking Left Ventricular Myocardial Fiber Orientation
Authors: Hwang Dong Gyu , Choi Hwanyong , Yong Uijung , Kim Donghwan , Kang Wonok , Park Sung‐Min , Jang Jinah 
Published: May 2024

AbstractLeft ventricular twist is influenced by the unique oriented structure of myocardial fibers. Replicating this intricate structural‐functional relationship in an in vitro heart model remains challenging, mainly due to the difficulties in achieving a complex structure with synchrony between layers. This study introduces a novel approach through the utilization of bioprinting‐assisted tissue assembly (BATA)—a synergistic integration of bioprinting and tissue assembly strategies. By flexibly manufacturing tissue modules and assembly platforms, BATA can create structures that traditional methods find difficult to achieve. This approach integrates engineered heart tissue (EHT) modules, each with intrinsic functional and structural characteristics, into a layered, multi‐oriented tissue in a controlled manner. EHTs assembled in different orientations exhibit various contractile forces and electrical signal patterns. The BATA is capable of constructing complex myocardial fiber orientations within a chamber‐like structure (MoCha). MoCha replicates the native cardiac architecture by exhibiting three layers and three alignment directions, and it reproduces the left ventricular twist by exhibiting synchronized contraction between layers and mimicking the native cardiac architecture. The potential of BATA extends to engineering tissues capable of constructing and functioning as complete organs on a large scale. This advancement holds the promise of realizing future organ‐on‐demand technology.
Molecular‐Engineered Wool for Sustainable All‐Weather Radiative Cooling Textiles
Authors: Ao Shuyu , Li Benhui , Hu Xiaorui , Su Xuzhong , Sun Fengxin 
Published: May 2024

AbstractPersonal thermal regulation through passive radiative cooling is an effective strategy to achieve sustainable development. Although recent advances have introduced various cooling textile designs, the extensive use of materials unsuitable for common textiles, alongside coating or compositing technologies, not only compromises the wearability and safety of these textiles but also impacts green sustainability. Herein, it is shown that wool is a promising natural material for transferring mid‐infrared human body radiation, but the high absorption in the solar spectrum prohibits wool from achieving satisfactory daytime radiative cooling. Thus the natural wool impregnates zinc ions into the protein chains to form a zinc‐ion woolen (wool‐Zn) fabric. The wool‐Zn fabric can provide humans with a cooling sensation both indoors and daytime outdoors, showing a temperature reduction of 2 °C on human skin indoors and a reduction of 7 °C on artificial skin under direct sunlight, respectively, when covered by wool‐Zn fabrics compared to when covered with cotton. Moreover, the wool‐Zn fabric shows desirable antibacterial properties and durability against washing and abrasion, while maintaining desirable wearability. As a result, the wool‐Zn fabric shows great potential for commercial application in personal thermoregulation and provides an effective avenue toward sustainable energy and environment.
Machine Learning‐Enhanced Prediction of Inorganic Semiconductor Bandgaps for Advancing Optoelectronic Technologies
Authors: Zeb Muhammad Husnain , Rehman Abdul , Siddiqah Mariyam , Bao Qiaoliang , Shabbir Babar , Kabir M. Z. 
Published: May 2024

AbstractA pivotal challenge in advancing inorganics optoelectronic technologies, is the precise characterization of materials' electronic attributes, with the bandgap being a critical property. Conventional approaches, heavily reliant on time‐intensive and financially demanding experimental and computational methods, such as density functional theory (DFT) calculations, face limitations due to inherent estimation errors. Machine learning methodologies are developed for the prediction of bandgaps of inorganic semiconductors but most of them are employed for datasets created by DFT calculations, hence limiting their performance. Addressing this, the study leverages machine learning methodologies, harnessing both compositional and structural features, to predict the band gaps of inorganic semiconductors with enhanced accuracy. This advancement is reinforced by the employment of an experimental bandgap dataset, which, when integrated with structural descriptors obtained from the Materials Project, significantly improves prediction capabilities. This is evidenced by the model's exceptional performance across two distinct benchmark datasets. Furthermore, the model's adeptness in predicting formation energies underscores its versatility and applicability to a broad spectrum of electronic properties. These findings suggest that the predictive accuracy of this model can be further augmented through the inclusion of additional experimental bandgap measurements and the refinement of structural descriptors. This approach offers a promising and efficient alternative to traditional methodologies, potentially accelerating the development of optoelectronic technologies.
Three Birds with One Stone: Multifunctional Separators Based on SnSe Nanosheets Enable High‐Performance Li‐, Na‐ and K‐Sulfur Batteries
Authors: Li Canhuang , Yang Dawei , Yu Jing , Wang Jian , Zhang Chaoqi , Yang Tianxiang , Huang Chen , Nan Bingfei , Li Junshan , Arbiol Jordi , Zhou Yingtang , Zhang Qiaobao , Cabot Andreu 
Published: May 2024

AbstractAlkali metal‐sulfur batteries (MSBs) are one of the most promising next‐generation energy storage technologies due to their high energy density and potential for low cost. They are nonetheless constrained by the sluggish conversion of metal polysulfides (MPS) during the charge/discharge process. Herein, a multifunctional separator able to trap the MPS and catalyze their conversion in the three main MSB chemistries, Li‐, Na‐, and K‐MSBs, is demonstrated. More in detail, SnSe nanosheets are introduced as additive into the cathode side of the glass microfiber (GF) separator of the MSB. Taking lithium‐sulfur batteries (LSBs) as an example, it is demonstrated that the GF‐SnSe separator (GF@SnSe) shows strong chemical affinity to lithium polysulfides (LiPS) and superior catalytic activity, inhibiting the transport of LiPSs to the anode and accelerating their conversion. Combining experimental and calculation results, the SnSe additive is shown to decrease the Li2S decomposition energy barrier. Overall, GF@SnSe separators provide significantly improved LSB rate performance and cycling stability with a 0.049% capacity decay per cycle. Besides, the GF@SnSe separator promotes the electrochemical performance of sodium‐sulfur and potassium‐sulfur batteries. Overall, this work presents a significant advancement in the development of multifunctional separators in LSBs as well as the emerging Na‐S and K‐S systems.
Developmental milestones in captive Galago moholi
Authors: McGovern‐Lind Brenna R. , Proffitt Kathryn A. , King Scot E. E. , Rader Hannah M. , Violi Dominic A. , Llera Martin Catherine J. , Searight Katherine , Kehrer Matthew , Yeropoli Brandon A. , Young Jesse W. , Vinyard Christopher J. , DeLeon Valerie B. , Smith Timothy D. 
Published: May 2024

AbstractSystems of the body develop in a modular manner. For example, neural development in primates is generally rapid, whereas dental development varies much more. In the present study, we examined development of the skull, teeth, and postcrania in a highly specialized leaping primate, Galago moholi. Eighteen specimens ranging from birth to adult were studied. Bones, teeth, and the cranial cavity (i.e., endocast) were reconstructed with Amira software based on microCT cross‐referenced to histology. Amira was also used to compute endocast volume (as a proxy for brain size). Reconstructions of the wrist and ankle show that ossification is complete at 1 month postnatally, consistent with the onset of leaping locomotion in this species. Endocranial volume is less than 50% of adult volume at birth, ~80% by 1 month, and has reached adult volume by 2 months postnatal age. Full deciduous dentition eruption occurs by 2 weeks, and the young are known to begin capturing and consuming arthropods on their own by 4 weeks, contemporaneous with the timing of bone and ankle ossification that accompanies successful hunting. The modular pattern of development of body systems in Galago moholi provides an interesting view of a “race” to adult morphology for some joints that are critical for specialized leaping and clinging, rapid crown mineralization to begin a transitional diet, but perhaps more prolonged reliance on nursing to support brain growth.
Altered fornix integrity is associated with sleep apnea‐related hypoxemia in mild cognitive impairment
Authors: Marchi Nicola Andrea , Daneault Véronique , André Claire , Martineau‐Dussault Marie‐Ève , Baril Andrée‐Ann , Thompson Cynthia , Montplaisir Jacques Yves , Gilbert Danielle , Lorrain Dominique , Boré Arnaud , Descoteaux Maxime , Carrier Julie , Gosselin Nadia 
Published: May 2024

AbstractINTRODUCTIONThe limbic system is critical for memory function and degenerates early in the Alzheimer's disease continuum. Whether obstructive sleep apnea (OSA) is associated with alterations in the limbic white matter tracts remains understudied.METHODSPolysomnography, neurocognitive assessment, and brain magnetic resonance imaging (MRI) were performed in 126 individuals aged 55–86 years, including 70 cognitively unimpaired participants and 56 participants with mild cognitive impairment (MCI). OSA measures of interest were the apnea‐hypopnea index and composite variables of sleep fragmentation and hypoxemia. Microstructural properties of the cingulum, fornix, and uncinate fasciculus were estimated using free water‐corrected diffusion tensor imaging.RESULTSHigher levels of OSA‐related hypoxemia were associated with higher left fornix diffusivities only in participants with MCI. Microstructure of the other white matter tracts was not associated with OSA measures. Higher left fornix diffusivities correlated with poorer episodic verbal memory.DISCUSSIONOSA may contribute to fornix damage and memory dysfunction in MCI.Highlights
Sleep apnea‐related hypoxemia was associated with altered fornix integrity in MCI.
Altered fornix integrity correlated with poorer memory function.
Sleep apnea may contribute to fornix damage and memory dysfunction in MCI.
Hydrogen Sensing with Palladium‐Based Materials: Mechanisms, Challenges, and Opportunities
Authors: Toksha Bhagwan , Gupta Prashant , Rahaman Mostafizur 
Published: May 2024

AbstractPalladium morphologies are prominently used in Hydrogen gas sensing applications owing to their unique characteristics and properties. In this review article, Palladium nanoparticles, thin films, and alloys were designated as the scope of Palladium morphologies. The aim of this review article is to explore Hydrogen sensing using Palladium, focusing on the recent advancements in the field.. The principles underlying Hydrogen sensing mechanisms with Palladium are discussed initially, highlighting the unique properties of Palladium that make it a promising material for this purpose. Special attention is given to the surface interactions and structural modifications that influence the sensitivity and selectivity of Palladium‐based sensors The study also addresses key challenges and recent innovations in the field which contribute to the enhancement of Palladium‐based Hydrogen sensing capabilities. The current state of research is critically examined to identify gaps in knowledge and future research directions are highlighted. The prospects and challenges associated with the use of Palladium for Hydrogen sensing, emphasizing its pivotal role in advancing sensor technologies for Hydrogen detection are also discussed.