bluuebunny/crossref_metadata_2025_split huggingface dataset:
ChemInform Abstract: EPR Investigations of Synthetic Manganese Complexes as Biomimics of the Water Oxidation Complex in Photosystem II
Authors: Huang P. , Kurz P. , Styring S. 
Published: May 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Saturation Transfer EPR Studies of Slow Rotational Motion in Membranes
Authors: Marsh D. 
Published: May 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Cytological criteria to predict basal phenotype of breast carcinomas
Authors: Dufloth Rozany Mucha , Alves Jacy Maria , Martins Diana , Vieira Daniella Serafin Couto , Chikota Horácio , Zeferino Luiz Carlos , Schmitt Fernando 
Published: May 2009

AbstractBreast carcinoma is a heterogeneous disease. It can be classified into phenotypes based on the expression of certain proteins, with distinct differences in prognosis. The basal phenotype is associated with worse prognosis and it still remains without specific treatment. However, there is currently no international consensus on the cytological criteria that could predict this phenotype. The purpose of the study was to evaluate the cytological criteria in fine‐needle aspiration biopsy and to identify their association with the basal phenotype of breast carcinoma. Fine‐needle aspiration biopsy specimens and tissue sections (mastectomy specimen) from 74 cases of high‐grade invasive ductal breast carcinomas were consecutively retrieved from the files of three institutions. Breast carcinomas were studied using the tissue microarray technique, being classified into phenotypes: luminal A, luminal B, HER2 overexpression, and basal. The cytological criteria for all cases were reviewed blindly by two pathologists according to five cytological criteria: cellularity, cell pattern, presence of necrosis, nucleoli, and nuclear atypia. Exact Fisher test was used to test the association between cytological criteria and the phenotypes of breast carcinoma. Necrosis was present in 64.7% of basal breast carcinomas, and 31.1% of nonbasal breast carcinomas, and that result was statistically significant, showing an odds ratio (OR) of 3.80. The basal phenotype, compared with the luminal A, showed more necrosis (OR = 6.97), present/prominent nucleoli (OR = 8.18), and cellularity more frequently (OR = 18.03). Necrosis, as well as present/prominent nucleoli and abundant cellularity are criteria more frequently associated to the basal phenotype of breast carcinoma. Diagn. Cytopathol. 2009. © 2009 Wiley‐Liss, Inc.
Significance of promoter hypermethylation of p16 gene for margin assessment in carcinoma tongue
Authors: Sinha Parul , Bahadur S. , Thakar Alok , Matta Ajay , Macha Muzafar , Ralhan Ranju , Gupta S. Datta 
Published: May 2009

AbstractBackgroundLoss of p16 expression by promoter hypermethylation has been reported as an early event in the development of oral cancer. The aim of our study was to explore the prognostic implications of presence of promoter hypermethylation of p16 gene in surgical margins in carcinoma tongue.MethodsA prospective analysis of 38 patients with resectable carcinoma tongue was carried out. DNA from tumor and the surgical margins was assessed by methylation‐specific polymerase chain reaction. Follow‐up duration was 17 to 37 months.ResultsAbout 86.8% of tumors showed promoter hypermethylation of p16 gene. Out of 30 patients with histologically free margins, 43.3% showed positivity on molecular assessment. Patients with positive molecular margins had a 6.3‐fold increased risk of having local recurrence as compared to patients with negative margins.ConclusionPromoter hypermethylation of p16 gene may serve as a useful molecular marker for predicting local recurrence in carcinoma tongue. © 2009 Wiley Periodicals, Inc. Head Neck, 2009
SERS as a probe for adsorbate orientation on silver nanoclusters
Authors: Fleger Y. , Mastai Y. , Rosenbluh M. , Dressler D. H. 
Published: May 2009

AbstractSurface‐enhanced Raman scattering (SERS) spectroscopy has been used to characterize multilayers of three isomeric aromatic compounds adsorbed on silver nanoclusters. The three structural isomers, all of which adsorb in the carboxylate form onto the silver nanoclusters, bind in two different geometries to the silver surface. Different molecular configurations correlate to differences in bonding strength of these molecules to the silver surface, which can be probed by SERS. For ortho‐hydroxybenzoic acid (salicylic acid), we observed red shifts of major SERS peaks in comparison to the normal Raman vibrations of nonadsorbed crystalline material. For this molecule the steric hindrance between the adjacent carboxylate and hydroxyl groups causes the carboxylate group to rotate from the common flat geometry of benzene substituents on surfaces and bond directly through one of the oxygen atoms to the surface. In this case, strong coordinative bonding between the carboxylate group and the metal surface causes the red shifts in the SERS peaks. For para‐, and meta‐hydroxybenzoic acid, the steric hindrance is less likely since the two functional groups are not at adjacent positions, and therefore these molecules adsorb on the silver surface in a totally flat geometry. For these molecules, in contrast to the ortho isomer, the CO2 interacts with the surface through an extended π bond, and these molecules are physically adsorbed in the common flat position. Therefore, for the meta and para substituents, we do not observe significant red shifts in the SERS spectrum. Copyright © 2009 John Wiley & Sons, Ltd.
Molecular structure, NMR and vibrational spectral analysis of 2,4‐difluorophenol by ab initio HF and density functional theory
Authors: Subramanian M. K. , Anbarasan P. M. , Manimegalai S. 
Published: May 2009

AbstractQuantum chemical calculations of energies, geometries and vibrational wavenumbers of 2,4‐difluorophenol (2,4‐DFP) were carried out by using ab initio HF and density functional theory (DFT/B3LYP) methods with 6‐311G(d,p) as basis set. The optimized geometrical parameters obtained by HF and DFT calculations are in good agreement with related molecules. The best level of theory in order to reproduce the experimental wavenumbers is the B3LYP method with the 6‐311G(d,p) basis set. The difference between the observed and scaled wavenumber values of most of the fundamentals is very small. A detailed interpretation of the infrared and Raman spectra of 2,4‐DFP is also reported. The entropy of the title compound was also performed at HF/6‐311G(d,p) and B3LYP/6‐311G(d,p) levels of theory. The isotropic chemical shift computed by 1H, 13C NMR analyses also shows good agreement with experimental observations. The theoretical spectrograms for FT‐IR and FT‐Raman spectra of the title molecule have been constructed. Copyright © 2009 John Wiley & Sons, Ltd.
Should we use laparoscopic adrenalectomy for metastases? Scandinavian multicenter study
Authors: Marangos Irina Pavlik , Kazaryan Airazat M. , Rosseland Arne R. , Røsok Bård I. , Carlsen Hege S. , Kromann‐Andersen Bjarne , Brennhovd Bjørn , Hauss Hans J. , Giercksky Karl‐Erik , Mathisen Øystein , Edwin Bjørn 
Published: May 2009

AbstractIntroductionLaparoscopic adrenalectomy for metastases is considered controversial. Multicenter retrospective study was performed to gain new knowledge in this issue.Materials and MethodsFrom January 1997 till November 2008, 41 adrenalectomies were performed during follow‐up of the patients operated for malignant tumors. The median age was 64 (52–77) years. Metastases were confirmed in 31/41 cases. Metastatic lesions were further studied and to define factors influencing on survival, patients were divided to sub‐groups of metachronous/synchronous, tumor origin and tumor size.ResultsThe median operative time was 104 (50–230) min, the median blood loss was 100 (0–500) ml. One procedure (3.2%) was converted. There were 3 (10.7%) intraoperative and 2 (7.4%) postoperative complications. The median tumor size was 6 (1.5–16) cm. Pathohistological analysis revealed 12 colorectal, 9 renal cell carcinoma, 5 lung carcinoma, 4 melanoma, and 1 hepatocellular metastases. The resection margin was not free in one case (3.7%). The median hospital stay was 2 (1–21) days. The median length of survival was 29 ± 2.1 months for all patients.ConclusionLaparoscopic adrenalectomy for metastases is feasible regardless of their sizes. However these procedures should be performed by highly skilled laparoscopic surgeon in a fully equipped operating room and with a coordinated operation team. J. Surg. Oncol. 2009;100:43–47. © 2009 Wiley‐Liss, Inc.
Thiazole constrained analogues of the thevinones: synthesis and structure
Authors: Sipos Attila , Skaliczki Tímea , Berényi Sándor , Antus Sándor 
Published: May 2009

AbstractA simple synthesis of ring‐constrained endoethenomorphinans possessing 2′‐substituted thiazole ring 4–6 has been achieved by regio‐ and stereoselective Diels–Alder reaction of thiazolomorphinandienes 1–3 and methyl vinyl ketone in high yield (72, 64 and 87%, respectively). The structure of cycloaddition products was determined by high resolution mass spectrometry (HRMS), IR, 1D and 2D NMR techniques. Double‐pulsed field gradient spin‐echo–nOe and HMBC were found to be particularly powerful and indispensable tools in the exact structural elucidation of the presented new class of spatially constrained thevinones. Copyright © 2009 John Wiley & Sons, Ltd.
A comparative study of feature extraction and blind source separation of independent component analysis (ICA) on childhood brain tumour 1H magnetic resonance spectra
Authors: Hao Jie , Zou Xin , Wilson Martin P. , Davies Nigel P. , Sun Yu , Peet Andrew C. , Arvanitis Theodoros N. 
Published: May 2009

AbstractIndependent component analysis (ICA) has the potential of determining automatically the metabolite signals which make up MR spectra. However, the realiability with which this is accomplished and the optimal approach for investigating in vivo MRS have not been determined. Furthermore, the properties of ICA in brain tumour MRS with respect to dataset size and data quality have not been systematically explored. The two common techniques for applying ICA, blind source separation (BSS) and feature extraction (FE) were examined in this study using simulated data and the findings confirmed on patient data. Short echo time (TE 30 ms), low and high field (1.5 and 3 T) in vivo brain tumour MR spectra of childhood astrocytoma, ependymoma and medulloblastoma were generated by using a quantum mechanical simulator with ten metabolite and lipid components. Patient data (TE 30 ms, 1.5 T) were acquired from children with brain tumours. ICA of simulated data shows that individual metabolite components can be extracted from a set of MRS data. The BSS method generates independent components with a closer correlation to the original metabolite and lipid components than the FE method when the number of spectra in the dataset is small. The experiments also show that stable results are achieved with 300 MRS at an SNR equal to 10. The FE method is relatively insensitive to different ranges of full width at half maximum (FWHM) (from 0 to 3 Hz), whereas the BSS method degrades on increasing the range of FWHM. The peak frequency variations do not affect the results within the range of ±0.08 ppm for the FE method, and ±0.05 ppm for the BSS method. When the methods were applied to the patient dataset, results consistent with the synthesized experiments were obtained. Copyright © 2009 John Wiley & Sons, Ltd.
Does chromosome 17 centromere copy number predict polysomy in breast cancer? A fluorescence in situ hybridization and microarray‐based CGH analysis
Authors: Marchiò Caterina , Lambros Maryou B , Gugliotta Patrizia , Di Cantogno Ludovica Verdun , Botta Cristina , Pasini Barbara , Tan David SP , Mackay Alan , Fenwick Kerry , Tamber Narinder , Bussolati Gianni , Ashworth Alan , Reis‐Filho Jorge S , Sapino Anna 
Published: May 2009

AbstractApproximately 8% of breast cancers show increased copy numbers of chromosome 17 centromere (CEP17) by fluorescence in situ hybridization (FISH) (ie average CEP17 >3.0 per nucleus). Currently, this pattern is believed to represent polysomy of chromosome 17. HER2‐amplified cancers have been shown to harbour complex patterns of genetic aberrations of chromosome 17, in particular involving its long arm. We hypothesized that aberrant copy numbers of CEP17 in FISH assays may not necessarily represent true chromosome 17 polysomy. Eighteen randomly selected CEP17 polysomic cases and a control group of ten CEP17 disomic cases, as defined by dual‐colour FISH, were studied by microarray‐based comparative genomic hybridization (aCGH), which was performed on microdissected samples using a 32K tiling‐path bacterial artificial chromosome microarray platform. Additional FISH probes were employed for SMS (17p11.2) and RARA (17q21.2) genes, as references for chromosome 17 copy number. Microarray‐based comparative genomic hybridization revealed that 11 out of the 18 polysomic cases harboured gains of 17q with involvement of the centromere, one displayed 17q gain sparing the centromeric region, and only one could be defined as polysomic. The remaining five cases displayed amplification of the centromeric region. Among these, one case, showing score 2+ by immunohistochemistry and 8.5 HER2 mean copy number, was classified as not amplified by HER2/CEP17 ratio and as amplified by HER2/SMS ratio. Our results suggest that true chromosome 17 polysomy is likely to be a rare event in breast cancer and that CEP17 copy number greater than 3.0 in FISH analysis is frequently related to gain or amplification of the centromeric region. Larger studies investigating the genetic profiles of CEP17 polysomic cases are warranted. Copyright © 2009 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
Down‐regulated expression of SATB2 is associated with metastasis and poor prognosis in colorectal cancer
Authors: Wang Shuang , Zhou Jun , Wang Xiao‐Yan , Hao Jun‐Mei , Chen Juan‐Zhi , Zhang Xiang‐Mei , Jin He , Liu Li , Zhang Yan‐Fei , Liu Jinsong , Ding Yan‐Qing , Li Jian‐Ming 
Published: May 2009

AbstractTo identify novel biomarkers of metastasis of colorectal cancer (CRC), we developed an orthotopic implantation model of murine CRC and selected in vivo M5, a subclone of the SW480 CRC cell line with enhanced potential for metastasis to the liver. We compared the differences in the gene expression profiles between M5 and SW480 cells using gene expression profiling. We found that expression of special AT‐rich sequence‐binding protein 2 (SATB2) was down‐regulated in M5 cells. Immunohistochemical analysis of 146 colorectal tumour samples showed that underexpression of SATB2 was strongly correlated with poor prognosis, tumour invasion, lymph node metastasis, distant metastasis, and Dukes' classification for CRC. Univariate and multivariate survival analyses further showed that SATB2 expression was a potential favourable prognostic factor for CRC. These results demonstrated not only that SATB2 is a potential novel prognostic factor for CRC, but also that selection of a highly metastatic clone of SW480 in vivo coupled with gene expression profiling is a powerful approach to identifying prognostic markers for CRC. Copyright © 2009 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
Poly(methyl methacrylate)/silica nanocomposite fibers by electrospinning
Authors: Chen Yi‐zhang , Zhang Zhan‐peng , Yu Jian , Guo Zhao‐Xia 
Published: May 2009

AbstractUniform poly(methyl methacrylate) (PMMA)/silica nanocomposite fibers containing up to 20 wt % silica were prepared by electrospinning. The electrospun solutions were prepared by mixing a solution of PMMA in dimethyl formamide (DMF) with colloidal silica in methyl ethyl ketone (MEK). The average fiber diameter decreases from 2.49 μm to 1.69 μm when 20 wt % silica is incorporated as a result of considerably increased solution conductivity, although the solution viscosity increases significantly, which should result in opposite effect. Thinner fibers (down to 350 nm) can be obtained by changing DMF/MEK proportion and by the addition of an ammonium salt. Nano‐sized silica particles (10–40 nm) distributes homogeneously in the fibers, as revealed by transmission electron microscopy. Furthermore, the incorporation of silica nanoparticles can change the thermal properties and surface wettability of the fiber mats. © 2009 Wiley Periodicals, Inc. J Polym Sci Part B: Polym Phys 47: 1211–1218, 2009
Lymphoid bronchiolitis presenting at birth in an immunocompetent child: Chronic interstitial lung disease of unknown aetiology
Authors: Brodlie Malcolm , Flood Terry J. , Black Fiona , Spencer David A. 
Published: May 2009

AbstractA female infant presented at birth with respiratory distress, which was subsequently shown to be secondary to lymphoid bronchiolitis, an exceptionally rare condition in childhood. Over the following 13 years there has been a slow progressive deterioration in her respiratory status with forced expiratory volume in 1 sec currently 40% predicted. Tests for connective tissue disease, infection, or immunodeficiency have all been negative and in the absence of any other explanation we postulate that this severe problem may have occurred as a consequence of an unrecognized intrauterine infection. Pediatr Pulmonol. 2009; 44:622–624. © 2009 Wiley‐Liss, Inc.
Catecholamine alterations in pediatric obstructive sleep apnea: Effect of obesity
Authors: Snow Ayelet B. , Khalyfa Abdelnaby , Serpero Laura D. , Capdevila Oscar Sans , Kim Jinkwan , Buazza Muhamad O. , Gozal David 
Published: May 2009

AbstractStudy ObjectivesObstructive sleep apnea (OSA) elicits increased sympathetic activity in adults and increased urinary catecholamines. Moreover, urinary catecholamine excretion is altered in obese patients. We hypothesized that morning urine catecholamine levels would be correlated with the severity of obstructive sleep apnea and degree of obesity in children.MethodsChildren referred to the pediatric sleep center for habitual snoring underwent overnight polysomnography, and the first morning voided urine sample was collected. Urinary concentrations of norepinephrine, epinephrine and dopamine were measured and corrected for creatinine levels. In a subset of children, blood samples were drawn and gene expression of catecholamine‐relevant genes analyzed by quantitative real‐time PCR.ResultsOne hundred fifty‐nine children were recruited and completed the protocol. Children with OSA had significantly higher urinary norepinephrine and epinephrine levels, but not dopamine, compared to habitual snorers (norepinephrine: 40.1 ± 24.7 ng/mg creatinine vs. 31.6 ± 16.2 ng/mg creatinine, P < 0.01; epinephrine: 6.4 ± 10.5 ng/mg vs. 4.5 ± 0.5 ng/mg, P < 0.01). There was a positive correlation between norepinephrine and epinephrine values and polysomnographic indices, but no effect of obesity on catecholamine levels. In addition, expression of several of the major genes involved in synthesis and transport of catecholamines, as well as in selected receptors were compatible with increased bioavailability of catecholamines.ConclusionsIn children with OSA, morning urinary norepinephrine and epinephrine levels are significantly higher than those without OSA, and correlate with the severity of the disease. Gene expression patterns are in agreement with such findings. Urine catecholamine levels do not appear to be influenced by the presence of obesity. Thus, altered sympathetic activity in OSA patients appears to occur independently of the presence of obesity. Pediatr Pulmonol. 2009; 44:559–567. © 2009 Wiley‐Liss, Inc.
First occurrence of resistance to strobilurin fungicides in Microdochium nivale and Microdochium majus from French naturally infected wheat grains
Authors: Walker Anne‐Sophie , Auclair Christiane , Gredt Michel , Leroux Pierre 
Published: May 2009

AbstractBACKGROUND: Microdochium nivale (Fr.) Samuels & Hallet and Microdochium majus (Wollenweber) belong to the Fusarium ear blight (FEB) fungal complex affecting cereals. In 2007 and 2008, major Microdochium sp. infestations were observed in France, and the efficacy of strobilurins was found to be altered in some field trials. The aim of this study was to determine the sensitivity to strobilurins of French isolates of Microdochium and to characterise the possible mechanisms of resistance.RESULTS: Half of the strains collected in 2007 were resistant to strobilurins, and most also displayed strong resistance to benzimidazoles. Strobilurin resistance was found mostly in M. majus isolates. Positive cross‐resistance was observed between all strobilurins tested, but not with the phenylpyrrole derivative fludioxonil and the various classes of sterol biosynthesis inhibitors (SBIs). In most strains, resistance was correlated with the G143A substitution in cytochrome b, the molecular target of strobilurins. Two other mechanisms were also detected at lower frequencies.CONCLUSION: This is the first report of strobilurin resistance in Microdochium. Several resistance mechanisms have evolved independently in populations and may have different impacts on field efficacy. This makes the accurate detection and quantification of QoI resistance difficult. The management of field resistance and efficacy must be adapted to take these findings into account. Copyright © 2009 Society of Chemical Industry
Composition dependence of the coercivity in magnetic nanoparticles suitable for magnetic hyperthermia
Authors: Apostolova I. , Wesselinowa J. M. 
Published: May 2009

AbstractBased on the Heisenberg model including single‐site uniaxial anisotropy and using a Green's function technique we have studied the influence of size, shape and composition effects on the coercive field Hc saturation magnetization Ms and Curie temperature Tc of ferromagnetic nanoparticles. We have discussed various possibilities which could lead to decreasing of Hc and Tc and increasing of Ms It is shown that spherical Ni–Pd, Fe–Pt and Zn–Co‐ferrite nanoparticles with d ≈ 10 nm are suitable for magnetic hyperthermia applications. (© 2009 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Preface: Phys. Status Solidi C 6/5
Authors: The Guest Editors  , Sadewasser Sascha , Abou‐Ras Daniel , Lake Bella , Schock Hans‐Werner , Schorr Susan 
Published: May 2009

AbstractThe 16th International Conference on Ternary and Multinary Compounds (ICTMC16) in Berlin, Germany, followed the series of conferences initiated in 1973 in the tradition of being an interdisciplinary forum for the exchange of information and experience in the exciting field of materials science of ternary and multinary compounds.The conference brought together scientists from different fields, namely physics, chemistry, crystallography and materials science. The ICTMC16 gave the opportunity to discuss and learn about new advances and high level applications in the field of these complex materials. The conference covered all aspects of basic and applied research on ternary and multinary compounds in different fields: semiconductors, magnetic semiconductors, magnetic materials as well as ferro‐ and piezoelectrics.We were happy about a broad participation: about 200 contributions from 24 countries set the basis for an exciting meeting. The scientific program included 15 invited talks, 39 oral and about 140 poster presentations. Most of these contributions are included in the present proceedings.We would like to thank the International Advisory Committee, the Program Committee, the sponsors and to all who have contributed to this conference for their support and advice (© 2009 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)