bluuebunny/crossref_metadata_2025_split huggingface dataset:
Rebuilding the health sector in Gaza: alternative humanitarian voices
Authors: Blanchet Karl , Najem Martine , Shadid Lina , Fehmi Rouba Ali , Al Hammouri Fawzi , Saed Ghassan , Saleh Khaled J. , Nasser Mosab , Moukaddam Nidal , Polonsky Jonathan , Lattouf Omar 
Published: May 2024

AbstractIn November 2023, a variety of disparate health organizations formed an international coalition to consolidate efforts and develop collaborative strategies in response to the increasing critical healthcare challenges caused by the recent war in Gaza. The coalition includes medical and public health experts, humanitarian practitioners, academics, and health policy-makers from across the world. Their membership has not much to do with mainstream humanitarian organisations. It is lead by the diaspora from the region. Their vision is the long-term reconstruction of the health system in Gaza while responding the most urgent needs. This collective effort will require explicit efforts to speak with one voice and avoid duplication. This collective movement may be an orginal initiative that may be able to beat the expected international donor fatigue.
Intermittent blood flow restriction with low-load resistance training for older adults with knee osteoarthritis: a randomized, controlled, non-inferiority trial protocol
Authors: Hong Qiao-Mei , Wang Hao-Nan , Liu Xi-Hui , Zhou Wen-Qi , Luo Xiao-Bing 
Published: May 2024

Abstract
Background
Knee osteoarthritis (KOA) is a chronic musculoskeletal disorder characterized by pain and functional impairment. Blood flow restriction (BFR) with low-load resistance training (LLRT) demonstrates a similar improvement in clinical outcomes to high-load resistance training (HLRT) in treating KOA. It has not been established whether intermittent blood flow restriction (iBFR) with LLRT can lead to clinical outcomes that are comparable to those produced by continuous blood flow restriction (cBFR) with LLRT and HLRT. The aim of the proposed study is to evaluate the efficacy of iBFR with LLRT on pain, Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), muscle strength, muscle mass, physical function, perceptions of discomfort and effort, and adherence in KOA patients.

Methods
This is a three-arm, non-inferiority, randomized controlled trial utilizing blinded assessors. Two hundred thirteen participants will be randomly allocated to one of the following three groups: iBFR group—receiving 4 months of LLRT with iBFR, twice weekly (n = 71); cBFR group—receiving 4 months of LLRT with cBFR, twice weekly (n = 71); or HLRT group—receiving 4 months of HLRT without BFR, twice weekly (n = 71). The primary outcome is pain. The secondary outcomes include the WOMAC, muscle strength, muscle mass, physical function, perceptions of discomfort and effort, and adherence. Pain and WOMAC will be measured at the baseline and 4 and 12 months after randomizations. Muscle strength, muscle mass, and physical function will be measured at the baseline and 4 months after randomizations. The perceptions of discomfort and effort will be measured during the first and final sessions.

Discussion
BFR with LLRT has a similar improvement in clinical outcomes as HLRT. However, cBFR may cause elevated ratings of perceived exertion and local discomfort, compromising patient tolerability and treatment adherence. If iBFR with LLRT could produce improvement in clinical outcomes analogous to those of HLRT and iBFR with LLRT, it could be considered an alternative approach for treating patients with KOA.

Trial registration
Chinese Clinical Trial Registry ChiCTR2300072820. Registered on June 26, 2023.
Modifying lignin composition and xylan O-acetylation induces changes in cell wall composition, extractability, and digestibility
Authors: Chaudhari Aniket Anant , Sharma Anant Mohan , Rastogi Lavi , Dewangan Bhagwat Prasad , Sharma Raunak , Singh Deepika , Sah Rajan Kumar , Das Shouvik , Bhattacharjee Saikat , Mellerowicz Ewa J. , Pawar Prashant Anupama-Mohan 
Published: May 2024

Abstract
Background
Lignin and xylan are important determinants of cell wall structure and lignocellulosic biomass digestibility. Genetic manipulations that individually modify either lignin or xylan structure improve polysaccharide digestibility. However, the effects of their simultaneous modifications have not been explored in a similar context. Here, both individual and combinatorial modification in xylan and lignin was studied by analysing the effect on plant cell wall properties, biotic stress responses and integrity sensing.

Results
Arabidopsis plant co-harbouring mutation in FERULATE 5-HYDROXYLASE (F5H) and overexpressing Aspergillus niger acetyl xylan esterase (35S:AnAXE1) were generated and displayed normal growth attributes with intact xylem architecture. This fah1-2/35S:AnAXE1 cross was named as hyper G lignin and hypoacetylated (HrGHypAc) line. The HrGHypAc plants showed increased crystalline cellulose content with enhanced digestibility after chemical and enzymatic pre-treatment. Moreover, both parents and HrGHypAc without and after pre-treating with glucuronyl esterase and alpha glucuronidase exhibited an increase in xylose release after xylanase digestion as compared to wild type. The de-pectinated fraction in HrGHypAc displayed elevated levels of xylan and cellulose. Furthermore, the transcriptomic analysis revealed differential expression in cell wall biosynthetic, transcription factors and wall-associated kinases genes implying the role of lignin and xylan modification on cellular regulatory processes.

Conclusions
Simultaneous modification in xylan and lignin enhances cellulose content with improved saccharification efficiency. These modifications loosen cell wall complexity and hence resulted in enhanced xylose and xylobiose release with or without pretreatment after xylanase digestion in both parent and HrGHypAc. This study also revealed that the disruption of xylan and lignin structure is possible without compromising either growth and development or defense responses against Pseudomonas syringae infection.
Malignancy is increased in patients with antineutrophil cytoplasmic antibody-associated vasculitis in China
Authors: Han Xiang-Yu , Li Zhi-Ying , Zhao Ming-Hui , Little Mark A. , Chen Min 
Published: May 2024

Abstract
Objective
It has been reported that in western countries malignancy risk was higher in patients with antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) compared with that in the general population. In the current study, we investigated the incidence, spectrum and risk factors of malignancy in Chinese AAV patients.

Methods
AAV patients diagnosed from 1995 to 2021 in Peking University First Hospital with a follow-up more than 12 months were recruited. Standardized incidence ratios (SIR) were calculated to describe the risk of malignancy, adjusted for sex, age and follow-up time.

Results
A total of 552 AAV patients were recruited, among which 23 patients had malignancies either preceding or concurrent with AAV diagnosis, and 43 of the remaining 529 patients developed malignancies within 4.3 ± 4.2 years post AAV diagnosis (SIR: 2.24; 95% CI: 1.68–2.99; p < 0.001). Among these 66 patients, twenty different sites of malignancy were observed, lung cancer being most frequent. To get exactly expected malignancies for the calculation of SIR, 529 patients without preceding or concurrent malignancies were included in the following analysis. Lung cancer was still the leading malignancy diagnosis (SIR: 5.01; 95% CI: 3.29–7.62), followed by malignancies in the kidney, bladder, ureter and prostate. Male gender (HR:2.84; 95%CI:1.36–5.96; p = 0.006) and older age (per year, HR:1.04; 95%CI:1.00-1.07; p = 0.038) were significantly associated with increased risk of malignancy. For patients with malignancy developed beyond 5 years after the diagnosis of AAV, a significantly higher malignancy risk was observed in those with a cumulative cyclophosphamide dose over 20.0 g (SIR: 11.54; 95% CI: 4.77–27.93; p < 0.001). Within the first 2 years after the diagnosis of AAV, the risk of malignancy was still significantly higher than that in the general population, but the cumulative cyclophosphamide dose was not significantly associated with malignancy occurrence in this subgroup of patients.

Conclusions
Malignancy risk is higher in Chinese AAV patients than that in the general population, with a different malignancy spectrum from western countries. Both the use of cyclophosphamide and AAV per se might be associated with higher incidence of malignancy occurrence.
Efficacy of preoperative single-dose dexamethasone in preventing postoperative pulmonary complications following minimally invasive esophagectomy: a retrospective propensity score-matched study
Authors: Li Xiaoxi , Yu Ling , Yang Jiaonan , Fu Miao , Tan Hongyu 
Published: May 2024

Abstract
Background
The study was performed to investigate the efficacy and safety of preoperative dexamethasone (DXM) in preventing postoperative pulmonary complications (PPCs) after minimally invasive esophagectomy (MIE).

Methods
Patients who underwent total MIE with two-field lymph node dissection from February 2018 to February 2023 were included in this study. Patients who were given either 5 mg or 10 mg DXM as preoperative prophylactic medication before induction of general anesthesia were assigned to the DXM group, while patients who did not receive DXM were assigned to the control group. Preoperative evaluations, intraoperative data, and occurrence of postoperative complications were analyzed. The primary outcome was the incidence of PPCs occurring by day 7 after surgery.

Results
In total, 659 patients were included in the study; 453 patients received preoperative DXM, while 206 patients did not. Propensity score-matched analysis created a matched cohort of 366 patients, with 183 patients each in the DXM and control groups. A total of 24.6% of patients in the DXM group and 30.6% of patients in the control group had PPCs (P = 0.198). The incidence of respiratory failure was significantly lower in the DXM group than in the control group (1.1% vs 5.5%, P = 0.019). Fewer patients were re-intubated during their hospital stay in the DXM group than in the control group (1.1% vs 5.5%, P = 0.019).

Conclusions
Preoperative DXM before induction of anesthesia did not reduce overall PPC development after MIE. Nevertheless, the occurrence of early respiratory failure and the incidence of re-intubation during hospitalization were decreased.

Trial registration
Chinese Clinical Trial Registry (No. ChiCTR2300071674; Date of registration, 22/05/2023)
Prehabilitation of surgical patients: a bibliometric analysis from 2005 to 2023
Authors: Ma Wei , Liu Yijun , Liu Jin , Qiu Yanhua , Zuo Yunxia 
Published: May 2024

Abstract
Background
Good preoperative conditions help patients to counteract surgical injury. Prehabilitation is a multimodal preoperative management strategy, including physical, nutritional, psychological, and other interventions, which can improve the functional reserve of patients and enhance postoperative recovery. The purpose of this study is to show the evolution trend and future directions of research related to the prehabilitation of surgical patients.

Methods
The global literature regarding prehabilitation was identified from The Web of Science Core Collection database. Bibliometric methods of the Bibliometrix package of R (version 4.2.1) and VOSviewer were used to analyze publication trends, cooperative networks, study themes, and co-citation relationships in the field.

Results
A total of 638 publications were included and the number of publications increased rapidly since 2016, with an average annual growth rate of 41.0%. “Annals of Surgery”, “British Journal of Surgery” and “British Journal of Anesthesia” were the most cited journals. Experts from the USA, Canada, the UK, and the Netherlands contributed the most in this field, and an initial cooperative network among different countries and clinical teams was formed. Malnutrition, older patients, frailty, and high-risk patients were the hotspots of recent studies. However, among the top 10 cited articles, the clinical effects of prehabilitation were conflicting.

Conclusion
This bibliometric review summarized the most influential publications as well as the publication trends and clarified the progress and future directions of prehabilitation, which could serve as a guide for developing evidence-based practices.
Development of an organophosphate and carbamate pesticide test kit by using a magnetic particle coated with esterase enzyme from honey bee heads
Authors: Jaitham Udomsap , Kawichai Sawaeng , Yadoung Sumed , Tongchai Phannika , Jeeno Peerapong , Yana Pichamon , Chuttong Bajaree , Danmek Khanchai , Hongsibsong Surat 
Published: May 2024

AbstractOrganophosphates (OPs) and carbamates (CMs) play a vital role in Thai agriculture, public health, and pest control. However, their detection presents challenges due to expensive methods requiring specialized expertise. Addressing this gap, our study introduces an innovative, cost-effective method for detecting OPs and CMs in Thailand. We utilized the test kit by using magnetic particles coated with esterase enzymes from honey bee heads combined with a colorimetric approach. The developed test kit shows low limits of detection (LODs) at 0.001 mg/L of dichlorvos (OPs) and 0.004 mg/L for carbaryl (CMs). The efficiency of the developed test kits in comparison with the standard technique of gas chromatography with flame photometry detection (GC-FPD) shows a comparable result in fruit and vegetable residue analysis. This developed test kit proposes a cost-effective OPs and CMs analysis test kit for Thailand, promising expense reduction and simplified verification processes. Its applicability to fruits and vegetables signifies practicality in agriculture, marking a significant advancement in accessible and efficient pesticide residue monitoring. Despite challenges in pesticide use, our method holds promise for improving safety and efficiency in Thai pesticide management.
Graphical Abstract
Analysis of optical coherence tomography biomarker probability detection in central serous chorioretinopathy by using an artificial intelligence-based biomarker detector
Authors: Ferro Desideri Lorenzo , Anguita Rodrigo , Berger Lieselotte E. , Feenstra Helena M. A. , Scandella Davide , Sznitman Raphael , Boon Camiel J. F. , van Dijk Elon H. C. , Zinkernagel Martin S. 
Published: May 2024

Abstract
Aim
To adopt a novel artificial intelligence (AI) optical coherence tomography (OCT)-based program to identify the presence of biomarkers associated with central serous chorioretinopathy (CSC) and whether these can differentiate between acute and chronic central serous chorioretinopathy (aCSC and cCSC).

Methods
Multicenter, observational study with a retrospective design enrolling treatment-naïve patients with aCSC and cCSC. The diagnosis of aCSC and cCSC was established with multimodal imaging and for the current study subsequent follow-up visits were also considered. Baseline OCTs were analyzed by an AI-based platform (Discovery® OCT Fluid and Biomarker Detector, RetinAI AG, Switzerland). This software allows to detect several different biomarkers in each single OCT scan, including subretinal fluid (SRF), intraretinal fluid (IRF), hyperreflective foci (HF) and flat irregular pigment epithelium detachment (FIPED). The presence of SRF was considered as a necessary inclusion criterion for performing biomarker analysis and OCT slabs without SRF presence were excluded from the analysis.

Results
Overall, 160 eyes of 144 patients with CSC were enrolled, out of which 100 (62.5%) eyes were diagnosed with cCSC and 60 eyes (34.5%) with aCSC. In the OCT slabs showing presence of SRF the presence of biomarkers was found to be clinically relevant (> 50%) for HF and FIPED in aCSC and cCSC. HF had an average percentage of 81% (± 20) in the cCSC group and 81% (± 15) in the aCSC group (p = 0.4295) and FIPED had a mean percentage of 88% (± 18) in cCSC vs. 89% (± 15) in the aCSC (p = 0.3197).

Conclusion
We demonstrate that HF and FIPED are OCT biomarkers positively associated with CSC when present at baseline. While both HF and FIPED biomarkers could aid in CSC diagnosis, they could not distinguish between aCSC and cCSC at the first visit. AI-assisted biomarker detection shows promise for reducing invasive imaging needs, but further validation through longitudinal studies is needed.
Pore pressure-minimum horizontal stress coupling estimation in Tunu Field, Lower Kutai Basin, Indonesia
Authors: Ramdhan Agus M. , Fadlan Dhanny , O’Connor Stephen , Herdianto Roni , Radwan Ahmed E. , Arifin Arifin 
Published: May 2024

Quantifying the change of minimum horizontal stress (Shmin) in response to pore pressure is vital, particularly at the development stage of a hydrocarbon field. However, estimates of the coupling ratio between these parameters, either at basin or reservoir scales, are not well defined in Indonesia’s sedimentary basin, such as Lower Kutai Basin. This study investigates the coupling ratio between Shmin and pore pressure in one of the gas fields within the basin, Tunu Field, using available evidence from an extensive data set of direct pressure measurement, leak-off test, extended LOT, Mini-Frac, and lost circulation. Previous studies have reported overpressured and depleted reservoirs. Nevertheless, the evolution of Shmin due to the change in pore pressure has yet to be well established. This study reveals a Shmin and vertical stress ratio of 0.87 which may relate to the stiffening of the shales via clay diagenesis/cementation. Coupling ratios between Shmin and pore pressure are 0.3 for the overpressured zone at the basin scale and 0.42 for the depletion at the reservoir scale. The approach used has been shown to produce similar coupling ratio (or stress path) results to other basins globally, thus providing a useful estimate of the Shmin and pore pressure relationship for the Tunu Field, and potentially other fields in the Lower Kutai Basin. For the application to infill drillings within the field, this study indicates Shmin decreases in response to pore pressure depletion due to production, ranging from 1.7 to 2.3 ppg within the hydrostatic zone and from 2.5 to 3.7 within the overpressured zone, equivalent to a Pore Pressure (PP)-Shmin window decrease of approximately 28% to 37% and approximately 40% to 88%, respectively. In addition, strike-slip faulting is suggested as the likely in situ stress regime in the Tunu Field.
Integrative Therapies in Cancer Care: An Update on the Guidelines
Authors: Gowin Krisstina , Muminovic Meri , Zick Suzanna M. , Lee Richard T. , Lacchetti Christina , Mehta Ashwin 
Published: May 2024

INTRODUCTION ASCO and the Society for Integrative Oncology have collaborated to develop guidelines for the application of integrative approaches in the management of anxiety, depression, fatigue and use of cannabinoids and cannabis in patients with cancer. These guidelines provide evidence-based recommendations to improve outcomes and quality of life by enhancing conventional cancer treatment with integrative modalities. METHODS All studies that informed the guideline recommendations were reviewed by an Expert Panel which was made up of a patient advocate, an ASCO methodologist, oncology providers, and integrative medicine experts. Panel members reviewed each trial for quality of evidence, determined a grade quality assessment label, and concluded strength of recommendations. RESULTS Strong recommendations for management of cancer fatigue during treatment were given to both in-person or web-based mindfulness-based stress reduction, mindfulness-based cognitive therapy, and tai chi or qigong. Strong recommendations for management of cancer fatigue after cancer treatment were given to mindfulness-based programs. Clinicians should recommend against using cannabis or cannabinoids as a cancer-directed treatment unless within the context of a clinical trial. The recommended modalities for managing anxiety included Mindfulness-Based Interventions (MBIs), yoga, hypnosis, relaxation therapies, music therapy, reflexology, acupuncture, tai chi, and lavender essential oils. The strongest recommendation in the guideline is that MBIs should be offered to people with cancer, both during active treatment and post-treatment, to address depression. CONCLUSION The evidence for integrative interventions in cancer care is growing, with research now supporting benefits of integrative interventions across the cancer care continuum.
Poetry as Translation
Authors: Agamben Giorgio , Attell Kevin 
Published: May 2024

Abstract
This essay reflects on the constitutive bilingualism that characterizes the self-translation of twentieth-century poets in dialect into Italian. Here, Agamben proposes, the poem no longer dwells within the identity of one language but finds a true home in the white space that joins and divides the two texts, often printed on facing pages. Agamben traces back this poetic bilingualism to Dante, who contrasts the vernacular language, “which infants acquire from those around them,” and the language he calls “grammatical,” which we have to learn through a long course of study. This translative tension between two languages is not just an issue for poetry in dialect, but, as Hölderlin’s translations from Pindar and Sophocles clearly show, also defines every authentic poetic intention. Taking on this inherent bilingualism is, according to Agamben, the task of both the translator and the poet.
Does Rimbaud Get Ashbery?
Authors: Smith Matthew 
Published: May 2024

Abstract
This article offers a new approach for reading and evaluating translations by repurposing a long-standing model for assessing translations: the equivalence paradigm. Instead of decoupling a target text from a source text, or establishing an equal playing field between them—two common approaches used by recent theorists in translation studies—this article reverses the relationship between the two. The test case for this practice is John Ashbery’s translation of Rimbaud’s Illuminations. The exercise thus requires reading Rimbaud’s work as a translation of Ashbery’s “original” text. In this way, the clear hierarchy of values inherent in the equivalence paradigm is highlighted both to expose the model’s biases and to bring attention to the inimitable “originality” of a translation. In the end, although Rimbaud may be rightly appreciated as an unparalleled poet, many will find his appeal as a translator—at least as a translator of Ashbery—wanting.
Truchement serviteur de deux maîtresses
Authors: Tengour Habib 
Published: May 2024

Résumé
Il s’agit d’une réflexion personnelle d’un poète-traducteur algérien sur le rôle indispensable que la traduction a joué dans sa créativité poétique. Soulignant en particulier son éducation bilingue dans le contexte colonial algérien, il observe que ses traductions de poètes de l’anglais, de l’arabe et de l’allemand vers le français sont donc « doublement étrangères » parce que son français est imprégné de sa culture et de sa langue arabes. L’essai plaide en faveur de la coexistence pacifique de deux langues, et en particulier de la coexistence postcoloniale de l’arabe et du français, en tant qu’enrichissement mutuel. Tengour montre comment cette approche inclusive à la traduction, dans le context du bilinguisme algérien, informe non seulement son processus créatif mais aussi son travail éditorial, notamment Diwân ifriqiya, le volume quatre de la série Poems for the Millennium de l’University of California Press, et Poèmes du monde, une série de poèmes en traduction des Éditions Apic en Algérie, qui a publié plus de vingt poètes originaires d’une douzaine de pays au moins.