bluuebunny/crossref_metadata_2025_split huggingface dataset:
Use of the CD19 count in a primary care laboratory as a screening method for B-cell chronic lymphoproliferative disorders in asymptomatic patients with lymphocytosis
Authors: te Raa G. Doreen , Fischer Kathelijn , Verweij Wim , van Houte Arend J. , Kater Arnon P. , Biesma Douwe H. 
Published: November 2010

Abstract

Background: Detection of absolute and relative lymphocytosis in otherwise asymptomatic elderly patients is very common in the primary care setting and frequently results in referral for screening of lymphoproliferative disorders. Since many B-cell chronic lymphoproliferative disorders (B-CLPD) are indeed asymptomatic at diagnosis in most patients with lymphocytosis, no sign of such a disorder is usually detected. Currently, specific guidelines for screening of patients with lymphocytosis are lacking. We investigated the practicability and clinical value of a single colour CD19 count performed by a primary care laboratory in order to improve the diagnostic follow-up of patients with lymphocytosis in a primary care laboratory.

Methods: The capability of detecting monoclonal B-cell lymphocytosis and B-CLPD by CD19, was first confirmed in patient samples with known B-CLPD. Next, in a previously defined geographic area, a CD19 count was performed on all samples for patients aged ≥40 years with relative or absolute lymphocytosis but without neutropenia. Clinical follow-up, with a median of 4 years, was performed using both a survey among the requesting general practitioners and by analysis of the records of the referral hospitals within the borders of the defined area.

Results: A total of 520 cases with asymptomatic lymphocytosis were identified. In all cases, the CD19 count was performed; 207 (40%) showed increased values and 313 (60%) showed normal values. An increase in CD19 proved highly sensitive for detection of B-CLPD (98%, 95% CI; 94%–100%) with a high positive predictive value (57%, 95% CI; 50%–63%). The area under curve, the receiver-operating characteristic curve of the CD19 count (0.93, 95% CI; 0.91–0.96), was significantly higher compared to the absolute lymphocyte count (0.86, 95% CI; 0.83–0.89), especially in patients with moderate lymphocytosis.

Conclusions: This study indicates that the CD19 count, performed by a primary care laboratory, is feasible and a promising tool for initial screening of lymphocytosis to discriminate B-CLPD from benign causes of lymphocytosis.
ChemInform Abstract: Bismuth(III) Triflate Catalyzed Allylation of Cyclic Acetals and Dithianes Followed by in situ Derivatization to Generate Highly Functionalized Esters.
Authors: Krabbe Scott W. , Spafford Matthew J. , Mohan Ram S. 
Published: November 2010

AbstractA robust catalytic method for the allylation of cyclic acetals is reported.
ChemInform Abstract: Polyether‐Substituted Thiazolium Ionic Liquid Catalysts — A Thermoregulated Phase‐Separable Catalysis System for the Stetter Reaction.
Authors: Yu Fengli , Zhang Ruili , Xie Congxia , Yu Shitao 
Published: November 2010

AbstractA new type of thermoregulated thiazolium ionic liquid catalyst for the Stetter reaction is synthesized by introducing a polyether chain to the thiazole.
ChemInform Abstract: Highly Recyclable, Imidazolium Derived Ionic Liquids of Low Antimicrobial and Antifungal Toxicity: A New Strategy for Acid Catalysis.
Authors: Myles Lauren , Gore Rohitkumar , Spulak Marcel , Gathergood Nicholas , Connon Stephen J. 
Published: November 2010

AbstractImidazolium derived ionic liquid catalysts are developed which are aprotic, but can act as Broensted acidic catalysts in the presence of protic additives.
ChemInform Abstract: Synthesis of Dithiocarbamate by Markovnikov Addition Reaction in Aqueous Medium.
Authors: Halimehjani Azim Ziyaei , Marjani Katayoun , Ashouri Akram 
Published: November 2010

AbstractThe one‐pot three‐component reactions of amines (II), CS2 (III) with vinyl ethers (I) and (V) via Markovnikov addition affords dithiocarbamates (IV) and (VI) in high yields, complete regiospecificity and by an environmentally benign procedure.
ChemInform Abstract: Preparation of Anionic Phosphine Ligands in situ for the Palladium‐Catalyzed Buchwald/Hartwig Amination Reactions of Aryl Halides.
Authors: Yu Guang‐Ao , et al. et al. 
Published: November 2010

AbstractA wide range of (het)aryl halides smoothly undergoes Hartwig—Buchwald amination with aromatic and aliphatic amines in the presence of a novel Pd—phenylindenylphosphine complex.
ChemInform Abstract: Synthesis of 3‐Benzoyl Acrylates/Acrylamides via Dehydrogenation of 3‐Benzoyl Propionates/Propionamides Using IBX/p‐TsOH.
Authors: Li Ziyuan , Wang Yiyun , Tang Changhua , Xu Jinyi , Wu Xiaoming , Yao Hequan 
Published: November 2010

AbstractThe reaction conditions are optimized.
ChemInform Abstract: An E‐Factor Minimized Protocol for the Preparation of Methyl β‐Hydroxy Esters.
Authors: Fringuelli Francesco , Lanari Daniela , Pizzo Ferdinando , Vaccaro Luigi 
Published: November 2010

AbstractThe optimization of the preparation of title compounds (III) by a solvent‐free aldol reaction of aryl aldehydes (I) with enol ether (II) followed by desilylation is reported.
ChemInform Abstract: Efficient Preparation of Isothiocyanates from Dithiocarbamates Using Bromineless Brominating Reagent.
Authors: Yella Ramesh , Ghosh Harisadhan , Murru Siva , Sahoo Santosh K. , Patel Bhisma K. 
Published: November 2010

Abstract1,1′‐(Ethane‐1,2‐diyl)dipyridinium bistribromide (EDPBT) is used as easily accessible reagent for the direct conversion of dithiocarbamates into isothiocyanates.
ChemInform Abstract: Immobilization of Pd on Nanosilica Dendrimer as SILC: Highly Active and Sustainable Cluster Catalyst for Suzuki—Miyaura Reaction.
Authors: Hagiwara Hisahiro , Sasaki Hirokazu , Tsubokawa Norio , Hoshi Takashi , Suzuki Toshio , Tsuda Tetsuya , Kuwabata Susumu 
Published: November 2010

AbstractThe reusable catalyst is found to be effective for coupling reactions of aryl bromides and triflates and allows the preparation of ortho‐substituted biaryls under mild conditions.
ChemInform Abstract: A Green and Novel Method of Synthesizing 2,2′‐Arylmethylene Bis(3‐hydroxy‐5,5‐dimethylcyclohex‐2‐enone) Catalyzed by L‐Histidine in Ionic Liquid.
Authors: Zhang Yan , Shang Zhicai 
Published: November 2010

AbstractThe system L‐His / ionic liquid can be recycled several times with no decrease in yield or rate.
ChemInform Abstract: Synthesis of 2,4,5‐Substituted Oxazoles from 2‐Hydroxyaromatic Aldehydes.
Authors: Gavrilova N. A. , Pozhil'tsova O. S. , Semichenko E. S. , Suboch G. A. 
Published: November 2010

AbstractA two‐step procedure leads via stable oxazolium salt intermediates to novel oxazoles (III).
ChemInform Abstract: Catalytic and Efficient Oxidation of Urazole Derivatives to Their Corresponding Triazolinediones Using Ammonium Nitrate and Metal Hydrogen Sulfate as Catalyst.
Authors: Ghorbani‐Chogamarani Arash , Zeinivand Javad , Mallakpour Shadpour 
Published: November 2010

AbstractAdvantages are high selectivity, cost‐efficiency, and easy work‐up.
ChemInform Abstract: Reactions of 3‐Amino‐1,2,4‐triazoles with Cinnamic Aldehydes
Authors: Lipson V. V. , Karnozhitskaya T. M. , Shishkina S. V. , Shishkin O. V. , Turov A. V. 
Published: November 2010

Abstractformation of Schiff bases (III) and/or triazolopyrimidines (IV) depending on the reaction conditions
ChemInform Abstract: One‐Pot Three‐Component Access to Pyranocyclopentendiones.
Authors: Teimouri Mohammad Bagher , Mansouri Farideh 
Published: November 2010

AbstractIsocyanides, dialkyl acetylenedicarboxylates and 3,5‐diphenylcyclopentane‐1,2,4‐trione undergo smooth condensation reaction to afford title compounds, e.g. (IV), under mild reaction conditions.
ChemInform Abstract: An Efficient Synthesis of Oxa‐ and Aza‐Condensed Tetrahydropyridines from Cyclic Enones.
Authors: Zanatta Nilo , da Fernandes Liana S. , Muenchen Sinara , Coelho Helena S. , Amaral Simone S. , Fantinel Leonardo , Bonacorso Helio G. , Martins Marcos A. P. 
Published: November 2010

AbstractThe reaction of cyclic enones (I) with diamines or amino alcohols affords the products with high purity in good to excellent yields.
ChemInform Abstract: Pyrrolo[1,2‐a]quinoline Derivatives via 1,3‐Dipolar Cycloaddition of Quinolinium N‐Ylides.
Authors: Georgescu Emilian , Dumitrascu Florea , Georgescu Florentina , Draghici Constantin , Popa Marcel M. 
Published: November 2010

AbstractThe title compounds (IV) are synthesized by 1,3‐dipolar cycloaddition of in situ generated quinolinium N‐ylides with ethyl propiolate.
ChemInform Abstract: Synthesis and Biological Evaluation of Novel Benzodioxinocarbazoles (BDCZs) as Potential Anticancer Agents.
Authors: Ayerbe Nathalie , Routier Sylvain , Gillaizeau Isabelle , Maiereanu Carmen , Caignard Daniel‐Henry , Pierre Alain , Leonce Stephane , Coudert Gerard 
Published: November 2010

AbstractThe synthetic strategy consists of a palladium‐catalyzed Stille cross‐coupling reaction to (III) followed by photochemically induced 6π‐electrocyclization.
ChemInform Abstract: Preparation of Pyrimidine‐N‐oxides by Condensation of Functionalized Enamides with Hydroxylamine Hydrochloride.
Authors: Zimmer Reinhold , Lechel Tilman , Rancan Giaime , Bera Mrinal K. , Reissig Hans‐Ulrich 
Published: November 2010

AbstractReaction of enamides (I) with hydroxylamine hydrochloride proceeds under mild conditions to give the expected pyrimidine N‐oxides.
ChemInform Abstract: Microwave‐Assisted Synthesis of 4‐Amino‐2‐arylthieno[2,3‐d]pyrimidines and Their Subsequent Functionalization.
Authors: Chen Binbin , Perspicace Enrico , Hesse Stephanie , Kirsch Gilbert 
Published: November 2010

AbstractCoupling of 2‐amino‐3‐cyanothiophenes with aromatic nitriles affords the title skeleton.
ChemInform Abstract: Intramolecular Heterocyclization of N‐(Pyrimidin‐2‐yl)imines of Methyl Trifluoropyruvate.
Authors: Sokolov V. B. , Aksinenko A. Yu. 
Published: November 2010

AbstractThe title reaction affords 3‐fluoroimidazopyrimidinecarboxylates (IV).
ChemInform Abstract: The Mannich Reaction in the Synthesis of N,S‐Containing Heterocycles. Part 9. A New Approach to Thieno[2,3‐d]pyrimidines
Authors: Dotsenko V. V. , Krivokolysko S. G. , Litvinov V. P. 
Published: November 2010

Abstractvia three‐component reaction of 2‐amino‐3‐cyanodihydrothiophene (I) with p‐toluidine and formaldehyde
ChemInform Abstract: Reaction of 1‐Amino Bisphosphinic Acids with Acid Chlorides: Synthesis of Novel Cyclic 1‐Hydroxy‐1′‐amino‐1,1‐bisphosphinic Acids.
Authors: Kaboudin Babak , Saadati Fariba , Yokomatsu Tsutomu 
Published: November 2010

AbstractAminobisphosphinic acid (I) is activated by silylation with hexamethyldisilazane and subsequently treated with acid chlorides to give cyclic bisphosphinic acids (III).
ChemInform Abstract: Preparation of Dialkyl 1‐(Alkylamino)alkylphosphonates, Alkyl [1‐(Alkylamino)alkyl]phenylphosphinates and [1‐(Alkylamino)alkyl]diphenylphosphine Oxides via “in situ” Generated Iminium Ions.
Authors: Goldeman Waldemar , Soroka Miroslaw 
Published: November 2010

AbstractThe iminium ions react with phosphite (II), phosphonite (IV), and phosphinite (XI) to give the title compounds in good to excellent yields.
ChemInform Abstract: Synthesis of Cycloalkenyl Geminal Bisphosphonates by Ring Closing Metathesis.
Authors: Mohamed Salimo , Charmasson Yolande , Attolini Mireille , Maffei Michel 
Published: November 2010

AbstractFive‐ and six‐membered cycloalkenyl bisphosphonates (II) and (VI) are synthesized by ring closing metathesis in the presence of ruthenium alkylidene catalysts.
ChemInform Abstract: Synthesis of Antimicrobial Natural Products Targeting FtsZ: (+)‐Totarol (Ia) and Related Totarane Diterpenes.
Authors: Kim Michelle B. , Shaw Jared T. 
Published: November 2010

AbstractThe approach renders possible the preparation of title compound (Ia), totaradiol (Ib) and totarolone (Ic), which exhibit a comparable inhibition of the bacterial cell division protein.
ChemInform Abstract: Synthesis of the Guaianolide Ring System via Cycloaddition of a Bicyclic Carbonyl Ylide with Allyl Propiolate.
Authors: Navickas Vaidotas , Ushakov Dmitry B. , Maier Martin E. , Stroebele Markus , Meyer H.‐Juergen 
Published: November 2010

AbstractThe ester (I), readily available in 5 steps from (‐)‐carvone, is used as starting material in the sequence.
ChemInform Abstract: New Dammarane Saponins from the Steamed Ginseng Leaves
Authors: Tung Nguyen Huu , Song Gyu Yong , Kang Hee‐Kyoung , Kim Young Ho 
Published: November 2010

Abstractisolation, structure and cytotoxicity of two new dammarane‐type saponins, ginsenosides ST1 (Ia) and ST2 (Ib)
ChemInform Abstract: One Step Synthesis of Biotinylated Amino Acids.
Authors: Feng Siliang , Li Senhao , Kang Xiaoyu , Liu Keliang 
Published: November 2010

AbstractThe rapid preparation of biotinylated amino acids (III), (V), and (VII) is achieved by using a combination of biotin (II), HBTU, and DIEA as coupling reagents.
ChemInform Abstract: Molten Salt Synthesis, Characterization and Luminescence of ZnWO4:Eu3+ Nanophosphorus.
Authors: Yan Bing , Lei Fang 
Published: November 2010

AbstractThe red nanophosphor of title is synthesized by addition of molten MNO3 (M: Li, Na, K) to an aqueous solution of Zn(NO3)2, Eu(NO3)2, and Na2WO4.
ChemInform Abstract: One‐ and Two‐Dimensional Inorganic Crystals Inside Inorganic Nanotubes
Authors: Hong Sung You , Kreizman Ronen , Rosentsveig Rita , Zak Alla , Sloan Jeremy , Enyashin Andrey N. , Seifert Gotthard , Green Malcolm L. H. , Tenne Reshef 
Published: November 2010

AbstractReview: 74 refs.
Robust H∞ disturbance attenuation for uncertain systems with time‐varying delay
Authors: Yoneyama Jun 
Published: November 2010

AbstractThis paper discusses robust H∞ disturbance attenuation for an uncertain system with time‐varying delay. An appropriate Lyapunov functional, which takes into account the range of time‐delay and its derivative, is introduced to investigate robust H∞ disturbance attenuation. Less conservative results are obtained by such a Lyapunov functional with model transformation method and free weighting matrix method. Numerical examples are given to show the effectiveness of the proposed method. © 2010 Wiley Periodicals, Inc. Electron Comm Jpn, 93(12): 44–49, 2010; Published online in Wiley Online Library (wileyonlinelibrary.com). DOI 10.1002/ecj.10178
Direction control of information transfer between neuronal populations with asymmetric three‐dimensional microstructure
Authors: Hattori Shohei , Suzurikawa Jun , Kanzaki Ryohei , Jimbo Yasuhiko , Hamaguchi Tetsuya , Takahashi Hirokazu , Nakao Masayuki 
Published: November 2010

AbstractInformation transfer among neuronal populations has a directional bias. Some past studies demonstrated that microstructure could bias the direction of information transfer at a cellular level. However, the transfer at a population level has hardly been controlled to date. In order to control the information transfer, we attempt to bias the direction of neurite outgrowth of cultured neurons using a three‐dimensional asymmetric microstructure. The proposed microstructure is an embossed barrier with a right‐triangle cross section, namely, an ascending slope and vertical wall. Because of the asymmetricity, the neurite growth rate from the wall‐side to the slope‐side is expected to be lower than that of the slope‐to‐wall. We fabricated the microstructure on a polystyrene substrate by hot pressing, simultaneously embedding line electrodes for probing stimulation. To confirm the impact of the microstructure on neurite outgrowth, and thus the signal transfer direction between neuronal populations separated by the structure, we stimulated cultured neurons on both sides of the structure. There was a difference in neuronal responses to wall‐side stimulation and slope‐side stimulation, demonstrating the directional characteristic of information transfer. © 2010 Wiley Periodicals, Inc. Electron Comm Jpn, 93(12): 17–25, 2010; Published online in Wiley Online Library (wileyonlinelibrary.com). DOI 10.1002/ecj.10240
Preservative effect of an organic acid‐icing system on chilled fish lipids
Authors: García‐Soto Bibiana , Sanjuás Minia , Barros‐Velázquez Jorge , Fuertes‐Gamundi José R. , Aubourg Santiago P. 
Published: November 2010

AbstractThis study provides a first approach concerning a novel chilling strategy, which employs a mixture of different preservative organic acids (ascorbic, citric and lactic) in the icing medium. Thus, ice prepared from water including two different concentrations of a commercial acid mixture‐formula (800 and 400 ppm; C‐800 and C‐400 conditions, respectively) were applied as icing system to three important commercial fish lean species (hake, Merluccius merluccius; megrim, Lepidorhombus whiffiagonis; angler, Lophius piscatorius). Lipid oxidation (peroxide value; thiobarbituric acid index; fluorescent compound formation) and hydrolysis (free fatty acid formation) were evaluated throughout the chilling time (up to 12–15 days) and compared to results obtained in fish kept under traditional ice prepared only from water (C‐0 condition); a complementary sensory evaluation was carried out. As a result of employing the C‐800 icing condition, a partial inhibition of lipid oxidation and hydrolysis development was obtained that was accompanied by a shelf life enhancement in all cases. Further research taking into account the complementary action of the present organic acids is envisaged. According to the lipid damage analysis, lipid hydrolysis was a more relevant event than lipid oxidation in all fish species tested.
Natural mineral fire retardant fillers for polyethylene
Authors: Bellayer Séverine Patricia , Tavard E. , Duquesne S. , Piechaczyk A. , Bourbigot S. 
Published: November 2010

AbstractIn this article, we study the behaviour of common and low cost mineral fillers into a polyethylene matrix when exposed to mass loss calorimeter conditions. The different systems are made of linear low‐density polyethylene (LLDPE), with 50 wt% of calcium carbonate (CaCO3), magnesium carbonate or talc treated with stearic acid or nontreated. These systems were exposed to an external heat flux of 50 kW/m 2 and their burning behaviours were compared. Significant decrease of heat release rate peaks (PkHRR) was obtained with all these mineral fillers; however, even better results were obtained when particles were treated with stearic acid. Indeed, the system with CaCO3‐treated stearic acid leads to a surprising intumescent behaviour. A rheological study showed no impact of stearic acid on the viscosity of the system and did not explain the appearance of the intumescent phenomenon. However, scanning electron microscopy (SEM) shows that stearic acid enhances the dispersion of particles into the polymer and acts as a dispersive agent. The results also show that the aspect ratio of the particles, the cation nature of the carbonates and the polarity of the polymer matrix have an effect on the appearance or not on the intumescent phenomenon. Copyright © 2010 John Wiley & Sons, Ltd.
Insufficient peroxiredoxin‐2 expression in uterine NK cells obtained from a murine model of abortion
Authors: Yin Guangjie , Li Cui , Shan Bin , Wang Wenjing , Chen Hong , Zhong Yanmin , Di Jingfang , Lin Qide , Lin Yi 
Published: November 2010

AbstractThe CBA/J × DBA/2 mouse mating combination is prone to spontaneous embryo loss, in contrast to the MHC‐identical CBA/J × BALB/c mating combination, which yields successful pregnancies. The underlying mechanisms for these observations are unclear. In this study, multi‐vision immunohistochemical staining (IHC), flow cytometry and Western blot analysis were used to detect peroxiredoxin‐2 (PRX‐2) expression in the uterine natural killer (uNK) cells from CBA/J × DBA/2 and CBA/J × BALB/c mice. In IHC analysis, co‐localization of PRX‐2 and lectin from Dolichos biflorus agglutinin (DBA‐lectin) was confirmed and the frequency of PRX‐2+DBA‐lectin+ cells was significantly lower in CBA/J × DBA/2 than CBA/J × BALB/c. In flow cytometry and Western blotting, PRX‐2 was found expressed at a significantly lower level in CBA/J × DBA/2 mice. PRX‐2 inhibition with a neutralizing antibody significantly decreased PRX‐2 expression, increased the cytotoxicity of uNK cells, and increased the percentage of embryo loss in CBA/J × DBA/2J mice. Our data suggest that PRX‐2 may be involved in the modulation of maternal–fetal tolerance and that insufficient expression of this protein may correlate with increased embryo loss in CBA/J × DBA/2J mice. J. Cell. Biochem. 112: 773–781, 2011. © 2010 Wiley‐Liss, Inc.
Protein inherent structures by different minimization strategies
Authors: Rao Francesco 
Published: November 2010

AbstractNetwork‐based methods provide an accurate description of the free‐energy landscape of peptides and proteins sampled by molecular dynamics simulations. To that end, it is necessary to group the individual snapshots in a meaningful way. The inherent structures (ISs) provide an appropriate discretization of the trajectory into microstates, avoiding problems that can arise in clustering algorithms that have been used previously. In this work, different minimization protocols to obtain the IS of a peptide are investigated on the basis of cut‐based free‐energy profiles. It is found that a computationally more efficient quasi‐Newtonian algorithm provides quantitative agreement to the classical conjugate gradient method in terms of the population of the peptide substates and the energy barriers separating them. That is, despite the fact that the two algorithms can occasionally quench a given peptide snapshot in different potential energy minima, the overall properties of the system are not affected. As reported by others, atom permutations affect the calculation of the IS, requiring an improved implementation of current potential energy functions. © 2010 Wiley Periodicals, Inc. J Comput Chem, 2011
Leaf Extraction and Analysis Framework Graphical User Interface: Segmenting and Analyzing the Structure of Leaf Veins and Areoles
Authors: Price Charles A. , Symonova Olga , Mileyko Yuriy , Hilley Troy , Weitz Joshua S. 
Published: November 2010

Abstract
Interest in the structure and function of physical biological networks has spurred the development of a number of theoretical models that predict optimal network structures across a broad array of taxonomic groups, from mammals to plants. In many cases, direct tests of predicted network structure are impossible given the lack of suitable empirical methods to quantify physical network geometry with sufficient scope and resolution. There is a long history of empirical methods to quantify the network structure of plants, from roots, to xylem networks in shoots and within leaves. However, with few exceptions, current methods emphasize the analysis of portions of, rather than entire networks. Here, we introduce the Leaf Extraction and Analysis Framework Graphical User Interface (LEAF GUI), a user-assisted software tool that facilitates improved empirical understanding of leaf network structure. LEAF GUI takes images of leaves where veins have been enhanced relative to the background, and following a series of interactive thresholding and cleaning steps, returns a suite of statistics and information on the structure of leaf venation networks and areoles. Metrics include the dimensions, position, and connectivity of all network veins, and the dimensions, shape, and position of the areoles they surround. Available for free download, the LEAF GUI software promises to facilitate improved understanding of the adaptive and ecological significance of leaf vein network structure.