bluuebunny/crossref_metadata_2025_split huggingface dataset:
Psychometrics of the Persian version of Cyber Ethics Instrument among virtual students of medical sciences universities, Iran
Authors: Oveisi Sonia , Kohan Noushin , Tabatabaeichehr Mahbubeh , Ahmady Soleiman 
Published: June 2024

Abstract

Introduction
This study extended previous psychometric evaluations of the Persian version of Cyber Ethics Instrument (PCEI) by determining the factor structure, and internal consistency and providing convergent and discriminant evidence for its validity.
Method
In this descriptive study, we evaluated the psychometrics of the PCEI among virtual students of medical sciences universities in Iran from 2021 to 2023. Participants were 163 undergraduate students from two consecutive semesters in the same academic year. They ranged in age from 17 to 24 (M = 18.7, S.D. = 1.0) and 50.3% were women. The CEI tool which was developed by Winfred Yaokumah was used.
Results
A seven-factor solution emerged (32 items), invariant across gender and semester. These items were combined to create a PCEI with an overall reliability equal to 0.944. Results showed comparative fit index (CFI = .711), normed fit index (NFI = .635), TLI = .681, and root mean square error of approximation (RMSEA = .118). The 25 items that loaded on the model were Composite Reliability (CR) from 0.7315 to 0.8998 and Average Variance Extracted (AVE) from 0.4375 to 0.7142.
Conclusion
The results established the viability of PCEI for measuring cyber ethics in Iranian students. It deals with ethical issues and considerations concerning technology and online interactions, encompassing a wide range of topics such as Academic Integrity, Netiquette, Cyber Safety, Computer Ethics, Cyber Privacy, Cyber Security, and Cyber Protection to create a safe, inclusive, and ethical online environment.
Probabilistic Planning of Renewable Energy Source with Different Load Models
Authors: saleh ayat ali 
Published: June 2024

Abstract

this paper presents an optimization algorithm, named Non dominated Sorting Genetic Algorithm III (NSGA-III) method to identify the optimal allocation of hybrid distributed energy resources (DERs) including photovoltaic system (PV), micro-turbine (MT), and fuel cell (FC) in distribution system considering four different load models such as industrial, residential, commercial and constant load model. With increasing the integration of renewable energy resources, the uncertainties resulting from these sources posed a serious challenge to the operation of the network. To be closer to the reality, the network performance is analyzed considering the influence of the uncertainties produced from RES. Point Estimate Method (PEM) is used to model the uncertainties generated from renewable energy resources. The main aim of this paper is to maximize technical and economic benefits of DERs by minimizing various objective functions such as the total power loss, cost, and voltage deviation subject to different power system constraints. Multi-objective planning framework is appraised using two standards IEEE networks with various scenarios. Comparative analyses are conducted on standard distribution systems under different load model and mix of different types of DERs. Level diagram is implemented to analysis and compares the influence of different combinations of load models on the system performance. The obtained results show that, the system performance is greatly influenced by uncertainties accompanied with DER and power system itself. The suggested multi-objective planning frameworks shows high accuracy compared to other techniques applied in previous researches.
Study on the vibration prediction induced by tunnel blasting
Authors: Yao Yingkang , Shan Peng 
Published: June 2024

Abstract

Based on nonlinear theory and measurements in situ, a method for predicting the blasting vibrations using the NARMAX model is proposed. This model can be identified by the input and output signals measured in situ. Then, the predicted signal can be calculated at the specific measurement location using the identified NARMAX model. In addition, the blasting scheme can be optimized based on the predicted results to control the blasting vibration. The proposed method has been verified by a hammer impact test, and applied in a newly tunnel construction project. The results show that the method features convenient application, high precision and can provide scientific support and optimization for blasting operations.
The application of intraoperative vascular and biliary tract imaging in laparoscopic duodenum-preserving pancreatic head resection
Authors: Shen Zhengchao , Jiang Bin , Xi Shihang , Qian Daohai , Chen Suhang , Jiang Yaqi , Wang Xiaoming 
Published: June 2024

Abstract

Objective To investigate the value of applying intraoperative indocyanine green fluorescence imaging in laparoscopic duodenum-preserving pancreatic head resection.
Methods The clinical data of 12 patients with benign pancreatic head tumors who underwent fluorescence laparoscopic duodenum-preserving pancreatic head resection (FLDPPHR) at the Department of Hepatobiliary Surgery, the First Affiliated Hospital of Wannan Medical College, from June 2021 to October 2023 were retrospectively analyzed. All patients received an intravenous injection of indocyanine green (2.5 mg/ml, 1.5 ml) for biliary tract imaging half an hour before surgery. Indocyanine green (2.5 mg/ml, 1 ml) was intravenously injected into the peripheral vein when blood vessels needed to be exposed during the operation.
Results FLDPPHR was successfully performed in all 12 patients without conversion to open surgery. The tumor diameter was 3.6±0.1 cm, the operation time was 366.7±24.2 minutes, and the intraoperative blood loss volume was 270.8±25.7 ml. The median number of intraoperative vascular visualizations was 3 (2-4). Postoperative pathological diagnosis revealed intraductal papillary mucinous neoplasm (IPMN) in 6 patients, serous cystadenoma (SCN) in 4 patients, and mucinous cystadenoma (MCN) in 2 patients. The median postoperative hospital stay was 10 (7-40) days. No long-term complications occurred during the follow-up of more than 7 months.
Conclusion Real-time exposure of the common bile duct during indocyanine green fluorescence imaging is helpful for reducing damage to the common bile duct, visualizing vessels in the
Occurrence and Advancement of Diabetic Retinopathy in a Tertiary Care Setting: A Preliminary Report with Initial Overview and Recommended Protocols for Subsequent Screening
Authors: Mahar P. Salim , Monis Mohammad Daniyal , Khan M. Fahadullah , Ahsan Shahid , Memon M. Saleh 
Published: June 2024

Abstract

Background/Aims The objective of this study is to evaluate diabetic patients with either a normal fundus or non-proliferative diabetic retinopathy (NPDR) changes, examining retinal alterations during follow-up, and proposing follow-up guidelines within a tertiary eye care setting.Methods A 5-year prospective longitudinal study is being conducted at the Diabetic Clinic of Al Ibrahim Eye Hospital/Isra Postgraduate Institute of Ophthalmology, Karachi. Induction for the research took place from October 2021 to March 2022, and a 2-year preliminary report is presented here. Newly diagnosed type II diabetic patients with normal fundus or NPDR of any stage, irrespective of age, gender, or glycemic status, who were willing to participate and agreed to follow-ups, were included. Patients with proliferative diabetic retinopathy (PDR), diabetic macular edema (DME), fundus non-visibility, or systemic complications of diabetes were excluded.Results A total of 251 patients were enrolled, consisting of 80 individuals with a normal fundus and 171 with different stages of NPDR, including mild (n = 59), moderate (n = 91), and severe (n = 21) retinopathy. The incidence of progression from mild to moderate NPDR was noted to be 52.5%, with a median time of 3.5 months. Progression from moderate to severe NPDR occurred in 37.1% of cases, with a median time of 4.5 months. Similarly, DME developed in 5% of patients with mild NPDR over 8 months, in 22.2% with moderate NPDR over 7 months, and in 37.5% with severe NPDR over 4.4 months.Conclusion This study suggests that the incidence and progression of NPDR stages, along with the development of DME, may occur in a shorter duration in diabetic patients compared to what is suggested in existing literature.
Comparison of the efficacy and safety of different dose anlotinib in combination with immune checkpoint inhibitors for patients with advanced non-small cell lung cancer
Authors: Tan Tingfei , Yuan Siyu , Chu Weiwei , Jiang Jiemei , Chen Meiling , Xia Quan , Wang Junping 
Published: June 2024

Abstract

Purpose: The combination of anlotinib with immune checkpoint inhibitors (ICIs) has become a common treatment modality in clinical practice. However, the optimal dose of anlotinib to use remains unclear.
Methods: We collected patients with advanced non-small cell lung cancer (NSCLC) who received programmed cell death-1 (PD-1) or programmed cell death ligand 1 (PD-L1) blockade combined with different dose anlotinib as second-line or later line therapy. Subsequently, the efficacy and safety of the combination therapy as well as subgroup analyses of different doses of anlotinib were analyzed. Cox regression was performed to analyze significant factors correlated with progression-free survival (PFS) and overall survival (OS).
Results: A total of 50 eligible patients with NSCLC who received anlotinib combined with ICIs therapy were included, of which 27 received low-dose anlotinib (8 mg), and 23 were administered high-dose anlotinib (12 mg). The median PFS (mPFS) and the median OS (mOS) for all patients were 8.3 months (95% CI 6.3–10.3) and 17.6 months (95% CI 16.5–18.7), respectively. Subgroup analyses showed that patients treated with 8 mg of anlotinib plus ICIs had significantly longer mPFS than those treated with 12 mg of amlotinib plus ICIs (8.7 months vs 6.7 months; p=0.016). The overall incidence of adverse events (AEs) was 68.0%, and the most common AEs of all grades were hypertension. Meanwhile, the incidence of adverse events was higher for 12 mg of anlotinib plus ICIs than that of 8 mg of anlotinib plus ICIs(82.6% vs 55.6%, P = 0.041).
Conclusion: Low-dose anlotinib in combination with ICIs for advanced NSCLC may be an effective and well-tolerated option.
FAM83A: A Prospective Diagnostic Biomarker with Immunological Relevance in Lung Adenocarcinoma- Associated Malignant Pleural Effusion
Authors: Liu Hangfeng , Yao Jia , Liu Yulan , Wu Liping , Tan Zhiwei , Hu Jie , Chen Shigao , Zhang Xiaolin , Cheng Shuanghua 
Published: June 2024

Abstract

Background: Malignant pleural effusion (MPE) is most frequently observed in patients with advanced lung adenocarcinoma (LUAD). Pleural fluid cytology is a less invasive
procedure than pleural biopsy. Therefore, it is urgently required to discover new effective biomarkers for LUAD-associated pleural fluid cytology.
Methods: mRNA sequencing and clinical data of LUAD were downloaded from TCGA and OncoSG databases. Differential gene expression analysis, survival analysis and immune cell infiltration analysis were carried out on the LUAD datasets. The expression levels of FAM83A, TFF-1, and NapsinA were assessed in 94 pairs of LUAD tumor and adjacent normal tissues, as well as in pleural effusion cell blocks obtained from 40 LUAD and 21 non-neoplastic patients, using immunohistochemistry.
Results:Bioinformatics analysis demonstrated that FAM83A was screened out as a candidate biomarker for pleural fluid cytology due to its obvious difference in LUAD tissues and its influence on overall or disease-free survival, and histological grade. Immunohistochemistry showed that FAM83A expression was amplified in LUAD tissues compared with paired normal tissues in 89 out of 94 pairs. Immune cell infiltration analysis revealed that FAM83A expression was significantly correlated with immune cell infiltration, such as a positive association with macrophage infiltration. Meanwhile, FAM83A staining was positive in 37 cases of LUAD pleural effusions, and was negative in 20 cases of non-neoplastic pleural effusions. Additionally, the expression pattern of FAM83A in LUAD pleural effusions was relatively consistent with that of TFF-1 and NapsinA, and was even a little stronger in some LUAD pleural effusions that were weakly positive or negative for TTF1 or NapsinA.
Conclusions: Our work reveals FAM83A as a promising immune-related biomarker not only in LUAD biopsy specimens but also in LUAD pleural effusion. Our finding is of importance for providing a new and effective option for pleural fluid cytology.
Succinylome profiling the function and distribution of lysine succinylation in Saccharopolyspora erythraea
Authors: Ke Xiang , Jiang Xing , Hussain Muhammad Hammad , tian Xiwei , Chu Ju 
Published: June 2024

Abstract

As a novel protein post-translational modification, lysine succinylation is widely involved in metabolism regulation. To describe succinylated lysine's physiological functions and distribution patterns in Saccharopolyspora erythraea, a large and global protein succinylome was identified in a hypersuccinylated strain E3ΔsucC, using high-resolution 4D label-free mass spectrometry. Bioinformatic analysis was conducted to examine the succinylated proteins further in this study. The results showed that succinylated proteins were identified to be predominantly involved in protein synthesis, central carbon and nitrogen metabolism, and secondary metabolism. The process of lysine succinylation was found intricately regulated by a delicate interplay of factors, such as the relative abundance of lysine within the protein, the strategic positioning of polar amino acids flanking the succinylated sites, and the degree to which lysine residues are exposed to the solvent, thereby shaping the landscape of post-translational modifications. This systematic analysis represents the global analysis of lysine succinylation in S. erythraea and provides an important resource for exploring the the function of Ksucc and regulation in S. erythraea and likely in all actinomycetes.
Frequent intake of cakes attenuates the effect of energy drinks on activity of medial prefrontal cortex during calculation task
Authors: Kitamura Syuzo , Hasegawa Reana , Sakuma Yuka , Yoshihama Sara , Takatsuru Yusuke 
Published: June 2024

Abstract

Several caffeine-containing beverages, that is, energy drinks, are sold worldwide and many young adults frequently drink them, who believe that energy drinks give them increased energy and improve their performance in tasks. However, their effect on brain activity is controversial. In this study, we aim to clarify the effect of energy drinks on brain function, especially the activity of the medial prefrontal cortex (MPFC) and dorsolateral prefrontal cortex (DLPFC), by functional near-infrared spectroscopy (fNIRS) during calculation tasks. We found that the number of errors was not decreased and the concentration of cortisol in saliva was not improved by energy drink intake during calculation tasks. However, the calculation time was shortened by energy drink intake. We also found that activities of MPFC and DLPFC varied among the participants; they increased in one and decreased in others. We found that the participants with an increased MPFC activity following energy drink intake frequently drank milk and less frequently ate cakes. We concluded that the effect of energy drinks on MPFC activity during calculation tasks is limited and it varies depending on the frequency of food (milk and cakes) intake.
Anlotinib plus oral fluoropyrimidine S-1 in treating patients with refractory or relapsed small-cell lung cancer (SALTER TRIAL): an open-label, multicenter, single-arm, phase II trial
Authors: Wang Wei , Wu Guixian , Luo Wujun , Chen Ziran , Lin Ling , Zhou Chao , Yao Guifei , Chen Meifang , Wu Xiaomai , Ye Junhui , Yang Haihua , Lv Dongqing 
Published: June 2024

Abstract

Background
Patients with small-cell lung cancer (SCLC) have few treatment options and dismal overall survival (OS) after failed platinum-based chemotherapy.
Methods
The eligibility criteria of this phase II clinical trial included patients with measurable disease, age of 18 to 75 years, a confirmed diagnosis of disease progression or recurrence after prior platinum-based chemotherapy with a pathologically proven diagnosis of SCLC. Patients were treated with anlotinib at a dosage of 12mg once daily (QD) and S-1 at 60mg twice daily (BID) for 2 weeks, followed by a 1-week treatment-free interval. After six cycles of above treatment, patients were continued the maintenance therapy using S-1 monotherapy at 60mg/ BID for 2 weeks, followed by a 1-week treatment-free interval until disease progression.
Results
From March 2019 to June 2020, a total of 71 patients were initially assessed for eligibility in this study. Out of these, 52 patients who met the inclusion criteria were enrolled, and 48 patients received at least two doses of the study drug. The median follow-up time was 25.1 months. The ORR was seen in 21 patients (43.8%). The median PFS was 4.5 months (95% CI, 3.5–5.5 months), and the median OS was 5.9 months (95% CI, 4.6–7.3 months). The most common grade 3–4 treatment-related adverse events were thrombocytopenia (16.7%), anemia (14.6%), neutropenia (14.6%), and hypertension (10.4%). No treatment-related death occurred.
Conclusions
Treatment of anlotinib combined with oral fluoropyrimidine S-1 was active for relapsed or refractory SCLC in terms of ORR, having an acceptable and manageable safety profile.
Trial Registration
This trial was registered with ClinicalTrial.gov (NCT03823118) on 3 January 2019.
Estimating the carcinogenic and non-carcinogenic indices of lead for the vegetables fertilized with sewage sludge
Authors: Tehraninejad Maryam Tekyegah , Bostani Amir 
Published: June 2024

Abstract

Due to the presence of heavy metals in sewage sludge, their use for the fertilization of vegetables is of environmental and health significance. The objective was to investigate the non-carcinogenic and carcinogenic indices of lead (Pb), for children and adults, in the greenhouse vegetables fertilized with sewage sludge. The experiment was a factorial with three replicates, in which five levels of sewage sludge (0 (L1), 1.5 (L2), 3.0 (L3), 4.5 (L4) and 6% (L5)) were tested on spring onion (Allium fistulosum L.), radish (Raphanus satvius L.), cress (Lepidium sativum L.), basil (Ocimum basilicum), purslanes (Portulaca sp.), and summer savory (Satureja sp.). The effects of sewage sludge, vegetable type, and their interaction significantly affected the morphological properties of vegetables, average daily doses (ADD), hazard quotient (HQ), and cancer risk (CR) (P ≤ 0.01) in both children and adults. The highest and the least ADD was resulted by cress and savory. The L3 level increased HQ by 32% compared with control, which is five times higher than the safety level. Cress had the highest CR for children (0.0115) and adults (0.0037). According to the results the occurrence of cancer, which was likely for both children and adults, due to the consumption of vegetables, fertilized with sewage sludge, was three times higher for children. If the use of sewage sludge is desirable for the production of agricultural and horticultural crops, finding methods, which may decrease the concentration of heavy metals in sewage sludge is of outmost significance.
Construction of a PANoptosis-Related LncRNA Prognostic Model and Study on the Function of Linc01135 for Gastric Cancer
Authors: Zhao Zidong , Zhao Dandan , Liu Yanwen , Wu Kejian 
Published: June 2024

Abstract

Objective
Our study aimed to construct a predictive model for gastric cancer using PANoptosis-related LncRNAs. Additionally, the function of the model crucial molecule Linc01135 in gastric cancer cells will be explored.
Materials and Methods
We performed multiple Bioinformatics methods from the Cancer Genome Atlas (TCGA) database to develop a prediction signature. Fluorescence in situ hybridization (FISH) technology was utilized to analyze the localization of Linc01135. In addition, the function of Linc01135 on gastric cancer was assessed through various assays including CTG, colony formation, and scratch experiments. Finally, to identify specific proteins that bind with Linc01135, RNA Pulldown and Ribosome Immunoprecipitation (RIP) experiments were conducted.
Result
We developed a prognostic model for gastric cancer comprising of 7 lncRNAs. This model effectively distinguishes between high-risk and low-risk populations, as well as accurately predicts survival status. The subcellular localization of Linc01135 was found located in nucleus of HGC-27 cells. In terms of functionality, the knockdown of Linc01135 resulted in a significant reduction in the proliferation and migration abilities of gastric cancer cells. Mechanistically, Linc01135 exhibited specific binding affinity towards CDC45. Ultimately, rescue experiments demonstrated that overexpression of CDC45 partially counteracted the effects caused by knockdown of linc01135 on the proliferation and migration abilities of gastric cancer cells.
Conclusion
A predictive model based on PANoptosis-Related LncRNA can evaluate prognosis
Utilizing eDNA methods in biodiversity studies of river affected by anthropogenic pollution: A case study on the Batanghari River in Indonesia
Authors: Marnis Huria , Syahputra Khairul , Darmawan Jadmiko , Febrianti Dwi , Tahapari Evi , Larashati Sekar , Iswanto Bambang , Primanita Erma Primanita Hayuningtyas , Syaifudin Mochamad , Subangkit Arsad Tirta 
Published: June 2024

Abstract

The amalgamation of global climate change, escalating anthropogenic activities, and species invasions has resulted in a decrease in the biodiversity of aquatic organisms. The Batanghari River, one of Indonesia's longest rivers, is impacted by anthropogenic activities including pollution from mercury-containing waste originating from illegal gold mining (PETI), industrial pollutants, and domestic waste. Studies have highlighted a decrease in organismal biodiversity within the river, yet a comprehensive assessment of its current status is lacking. eDNA metabarcoding is a promising tool for understanding biodiversity of river affected by anthropogenic pollution, offering broader insights compared to traditional methods. We used eDNA metabarcoding to analyze biodiversity distribution in the Batanghari River, yielding 22,180,436 reads from 405 eDNA samples across 5 locations and 15 sites. Significant variations in beta diversity were observed among locations. Approximately 80% of reads were classified to the species level, with the remainder identified as unidentified taxa. Our findings underscore disparities in species richness and community composition between upstream and downstream areas, likely influenced by anthropogenic stressors. This method revealed the presence of several extinct and endangered species at multiple sampling locations. Understanding species diversity and distribution is crucial for advancing river ecology and conservation practices.