bluuebunny/crossref_metadata_2025_split huggingface dataset:
Development and Clinical Application of a Telemedicine Support System in the Field of Perinatal Patient Management
Authors: Kitagawa Michihiro , Akiyama Yoshiaki , Omi Hiroko , Sago Haruhiko , Natori Michiya 
Published: May 2010

AbstractIn recent years, perinatal patient management has been greatly improved due to the advance of medical technologies in various fields. The primary objectives of perinatal patient management are to discover signs and symptoms of fetal asphyxia and threatened premature delivery at an early stage and to initiate treatment as soon as possible. For this purpose, continuous monitoring of the fetal heart rate and uterine contractions is most effective.We developed a telemedicine support system for pregnant women and evaluated it to see if that makes it possible 1) to manage pregnant women monitored at home in the same way as those who visit hospitals on an ambulatory basis, and 2) to prevent adverse events in women in a high‐risk pregnancy. The findings obtained in the present study showed that this system is useful for both purposes.Perinatal telemedicine is expected to progress significantly in the next few years, although there are a number of issues that need to be resolved in this area.
Changes in Uterine and Ovarian Arterial Impedance during the Periovulatory Period in Conception and Nonconception Cycles
Authors: Yokota Akishige , Nakai Akihito , Oya Atsuko , Koshino Tatsuo , Araki Tsutomu 
Published: May 2010

AbstractObjective: To evaluate whether the Doppler velocimetry of uterine and ovarian arteries during the periovulatory period in conception cycles differs from that in nonconception cycles.Design: Transvaginal color Doppler sonography was used to assess uterine and ovarian perfusion in 63 infertile women during the periovulatory period.Results: In the conception cycles (n = 16), the PI values of uterine arteries at the day of ovulation were significantly less than those in nonconception cycles (n = 47). There were no significant differences in the PI values of ovarian arteries between the conception and nonconception cycles.Conclusions: In the present study, the conception cycles showed lower vascular impedance in the uterine during the periovulatory period than did the nonconception cycles. This endometrial perfusion presents an accurate noninvasive assay of uterine receptivity that can be used to predict the successful outcome of implantation and to reveal unexplained infertility problems.
Antenatal Diagnosis of Prune Belly Syndrome at 11 Weeks of Gestation
Authors: Yamamoto Hiroyuki , Nishikawa Satoshi , Hayashi Takuhiro , Sagae Satoru , Kudo Ryuichi 
Published: May 2010

AbstractWe present a case of prune belly syndrome diagnosed by ultrasonography at 11 weeks of gestation. We believe this case to be the earliest detection of this syndrome.
Metastatic Placental Site Trophoblastic Tumor: A Case Report
Authors: Aggarwal Neelam , Sawhney Harjeet , Vasishta Kala , Pathak Naina , Saran R. K. , Nijhawan Raje 
Published: May 2010

AbstractPlacental site trophoblastic tumor (PSTT) is very rare. It is an unusual variant of gestational trophoblastic neoplasia usually confined to the uterus, although 10% of patients have metastases. The clinical behaviour of PSTT varies and despite knowledge of its histology, diagnosis of this rare form of trophoblastic disease and prediction of its biological behaviour remains difficult due to only a few cases reported in literature.
Nitric Oxide Mediates Inhibitory Effect of Interleukin‐1β on Estrogen Production in Human Granulosa‐Luteal Cells
Authors: Tobai Hisako , Nishiya Iwao 
Published: May 2010

AbstractObjective:To investigate the effect of IL‐1β on NO production and steroidogenesis in human granulosa‐luteal cells obtained from women undergoingin vitrofertilization procedures.Subjects and Methods:To investigate the effect of IL‐1β, granulosa‐luteal cells were cultured with various doses of IL‐1β (0, 0.05, 0.5, 5, 50, 100 ng/ml), IL‐1β (5 ng/ml) withNG‐nitro‐L‐arginine‐methyl ester (l‐NAME), selective inhibitors of NOS, sodium nitroprusside (SNP), NO donors and Genistain, a tyrosine kinase inhibitor.Results:IL‐1β induced a dose‐dependent stimulation of NO production and inhibited the production of estradiol in a significant way in a dose‐dependent manner. l‐NAME significantly decreased NO production and increased the production of estradiol and progesterone. SNP significantly increased NO production and caused decreases in the production of both estradiol and progesterone. Genistain decreased NO production and significantly increased the production of estradiol and progesterone. Inducible NOS (iNOS) messenger RNA was present in granulosa‐luteal cells before treatment with IL‐1β.Conclusions:IL‐1β stimulated NO production, and NO inhibited the production of estradiol.
Gravid Uterus in an Incisional Hernia
Authors: Banerjee Neelam , Deka Deepika , Sinha Alka , Prasrad Rajinder , Takkar Deep 
Published: May 2010

AbstractA case of gravid uterus in an incisional hernia is reported. The pregnancy was further complicated by intrauterine growth restriction, oligohydramnios and pregnancy induced hypertension. The management of the case is discussed.
The Relationship of Human Papillomavirus (HPV) Detection to Pap Smear Classification of Cervical‐Scraped Cells in Asymptomatic Women in Northeast Thailand
Authors: Ekalaksananan Tipaya , Pientong Chamsai , Kotimanusvanij Daroon , Kongyingyoes Bunkerd , Sriamporn Supannee , Jintakanon Darunee 
Published: May 2010

AbstractObjective: To correlate the detection of human papillomavirus (HPV) with the Pap smear classification of cervical‐scraped cells from asymptomatic women living in northeast Thailand.Methods: A total of 260 asymptomatic women attending the Obstetrics and Gynecology's Outpatient Clinic, Srinagarind Hospital, Thailand, were interviewed for risk factors and cervical scrapes were taken. The cells were examined by Pap smear for cytological changes and by PCR for HPV DNAs – nononcogenic (HPVs 6 and 11) and oncogenic (HPVs 16, 18 and 33) types. Cervical biopsies were taken from women with abnormal Pap smears for histological examination.Results: Of the 260 cervical smear samples, the cervical cells were classified as normal and abnormal in 174 and 86, respectively. Twenty‐three percent of all samples were positive for overall HPV DNA. HPV DNAs (mostly HPVs 6 and 11) were detected in 21% of normal cells, and the higher detection rate (27%) for HPV DNA in abnormal cells gradually increased in severity from 16% in Class 3 to 35 and 60% in Classes 4 and 5, respectively. Histologically 46, 90 and 100% of HPV detection was associated with CIS, SCC and adenocarcinoma, respectively. Almost all of the HPV DNAs detected were types 16, 18 or 33. There was no significant association between HPV infection and reproduction history, sexual behavior and demographic variables.Conclusion: We speculated that an abnormal Pap smear and the detection of an oncogenic type HPV may indicate the presence of neoplastic cells in asymptomatic woman who might be at risk for the development of cervical cancer.
Management of Pregnancy with Congenital Antithrombin III Deficiency: Two Case Reports and a Review of the Literature
Authors: Yamada Takahiro , Yamada Hideto , Morikawa Mamoru , Kato Emi H. , Kishida Tatsuro , Ohnaka Yoshito , Nikaido Hiroki , Ozawa Tetsuo , Fujimoto Seiichiro 
Published: May 2010

AbstractWomen with antithrombin (AT) III deficiency are prone to pregnancy‐associated venous thromboembolism. We report 2 cases with genetically confirmed ATIII deficiency, one with a mutation in exon 3A and the other with an exon 4 deletion, in whom the pregnancies were successfully managed with prophylactic therapies for thrombosis. A 35‐year‐old pregnant woman was treated with intravenous infusions of ATIII concentrate alone, and the other 22‐year‐old pregnant woman was mainly treated with subcutaneous injections of heparin and oral low‐dose aspirin therapy. Both pregnancies resulted in vaginal deliveries of healthy neonates. The literature concerning prophylactic therapies for thrombosis in ATIII deficiency‐complicated pregnancy is reviewed, and the clinical problems, including the adverse effects of the therapies, are discussed.
Maternal Transmission of Helicobacter pylori in the Perinatal Period
Authors: Kitagawa Michihiro , Natori Michiya , Katoh Makoto , Sugimoto Kouhei , Omi Hiroko , Akiyama Yoshiaki , Sago Haruhiko 
Published: May 2010

AbstractObjectives: Studies indicate that Helicobacter pylori (HP) infection is closely related to gastric mucosa lesions and well‐differentiated gastric cancer. In Japan, the HP‐positive rate in childhood is 5–6%, which is similar to other developed countries, and in regard to the infection route, oral infection is considered important. To our knowledge there have been no reports on mother‐to‐child transmission and in this study we investigated maternal HP infection status to determine the potential of mother‐to‐child transmission in the perinatal period.Methods: After obtaining informed consent from 1,588 pregnant women, mother's blood and cord blood were collected at delivery to measure HP antibody (Helico‐G). Gastric contents from the neonates were cultured to isolate H. pylori (Skirrow medium). Vaginal discharge (73 women) and dental plaque scraping swabs (48 women) were collected before delivery, and milk (66 women) was collected after delivery from 212 HP antibody‐positive pregnant women to detect H. pylori by PCR.Results: The HP antibody‐positive rate for the pregnant women was 29.2%. H. pylori was not detected in the vaginal discharge from HP antibody‐positive pregnant women, but dental plaque scraping swabs from 4 women and milk from 4 women was positive.Conclusion: We considered that vertical infection during pregnancy or at delivery is unlikely as a route of mother‐to‐child HP antibody infection. However, horizontal infection through breast‐feeding may occur.
The Effect of Estradiol Vaginal Tablet and Conjugated Estrogen Cream on Urogenital Symptoms in Postmenopausal Women: A Comparative Study
Authors: Manonai Jittima , Theppisai Urusa , Suthutvoravut Somsak , Udomsubpayakul Umaporn , Chittacharoen Apichart 
Published: May 2010

AbstractObjectives: To compare the effects of estradiol vaginal tablet with conjugated estrogen cream on urogenital symptoms, vaginal health index, vaginal cytology, endometrial thickness, and plasma estradiol level in postmenopausal women.Methods: Fifty‐three women with urogenital symptoms were randomized to local vaginal treatment of 25 μg estradiol tablet or 1 g of conjugated estrogen cream for 12 weeks. They were assessed for urogenital symptoms, vaginal health index, vaginal cytology, endometrial thickness and estradiol level.Results: Forty‐eight women completed the treatment. Both groups showed improvement of urogenital symptoms, vaginal health index, and vaginal cytology after the first 4 weeks of treatment. Conjugated estrogen cream showed superior efficacy in alleviating vaginal dryness and dyspareunia. Two cases of endometrial proliferation were noted.Conclusions: Estradiol vaginal tablet and conjugated estrogen cream were effective in treating urogenital symptoms, the restoration of normal vaginal epithelium and reduction of vaginal pH in postmenopausal women. However, 2 cases of endometrial proliferation were noted.
Clinical Factors and Biomarkers Which Affect a New Universal Grading System for Ovarian Epithelial Carcinoma
Authors: Ishioka Shin‐ichi , Sagae Satoru , Sugimura Masaki , Nishioka Yoshihiro , Kobayashi Kanji , Kudo Ryuichi 
Published: May 2010

AbstractObjective: To detect clinical factors and biomarkers which affect a new grading system for ovarian epithelial cancer that was proposed by Shimizu et al. and to analyze the impact of those factors on malignant behaviors of the tumor.Methods: Review and scoring of specimens of paraffin embedded tissues of epithelial ovarian cancer were carried out according to the new universal grading system in 110 women who underwent initial treatments including the primary operation in our university hospital between January 1990 and June 1999. As biomarkers, expression of Bcl‐2, Bax, Bcl‐X, and the accumulation of P53 protein were also studied immunohistochemically.Results: This grading system functioned as a prognostic indicator. Five‐year survivals of the patients was 77.6, 36.3, and 17.4%, for Grade 1, Grade 2, and Grade 3, respectively. The grade was also correlated with clinical stages, histologic subtypes, operative completeness, para‐aortic lymph nodes metastasis, and the expression of Bax protein, with univariate analysis. Multivariate analysis revealed histological subtypes and para‐aortic lymph nodes metastasis to be important factors which affected the grading system.Conclusion: These results demonstrate that the new universal grading system is useful, and that this grading system might reflect potential of metastasis or dissemination of the ovarian cancer.
Liver Dysfunction in Late Pregnancy: Cytomegalovirus‐Induced Hepatitis or the HELLP Syndrome?
Authors: Ohkuchi Akihide , Minakami Hisanori , Suzuki Izumi , Ayustawati  , Izumi Akio , Sato Ikuo 
Published: May 2010

AbstractA 27‐year‐old primiparous preeclamptic woman developed a skin rash in late pregnancy and was persistently febrile for 10 days after giving birth. Blood tests suggested that she developed the HELLP syndrome and had concomitant cytomegalovirus (CMV) infection. Hemolysis, slightly impaired liver function, and thrombocytopenia were explainable by either only the CMV infection or only the HELLP syndrome. A literature review of a limited number of such cases and our case suggests that laboratory data in patients with CMV infection can mimic those of the HELLP syndrome. Thus, it may be important to consider CMV infection as a possible cause of abnormal laboratory data similar to the HELLP syndrome.
Severe and extensive neonatal hearing loss in cats results in auditory cortex plasticity that differentiates into two regions
Authors: Rajan R. , Irvine D. R. F. 
Published: May 2010

AbstractWe examined the response characteristics of primary auditory cortex (A1) neurons in adult cats partially but extensively deafened by ototoxic drugs 2–8 days after birth. The damage evoked extensive A1 topographic map reorganization as also found by others, but a novel finding was that in the majority of cats with low‐frequency edges to the cochlear lesion, the area of reorganization segregated into two areas expressing the same novel frequency inputs but differentiated by neuronal sensitivity and responsiveness. Immediately adjacent to normal A1 is an approximately 1.2‐mm‐wide area of reorganization in which sensitivity and responsiveness to sound are similar to that in normal A1 in the same animals and in unlesioned adult animals. Extending further into deprived A1 is a more extensive area of reorganization where neurons have poorer sensitivity and responsiveness to new inputs. These two areas did not differ in response‐area bandwidth and response latency. We interpret these novel changes as the cortical consequences of severe receptor organ lesions extending to low‐frequency cochlear regions. We speculate that the two areas of A1 reorganization may reflect differences in the transcortical spatial distribution of thalamo‐cortical and horizontal intracortical connections. Qualitatively similar changes in response properties have been seen after retinal lesions producing large areas of visual cortical reorganization, suggesting they might be a general consequence of receptor lesions that deprive large regions of cortex of normal input. These effects may have perceptual implications for the use of cochlear implants in patients with residual low‐frequency hearing.
Infrastructure Investment and Rural Economic Development: An Evaluation of USDA's Broadband Loan Program
Authors: KANDILOV IVAN T. , RENKOW MITCH 
Published: May 2010

ABSTRACTWe empirically evaluate whether participation in the U.S. Department of Agriculture's Broadband Loan Program, which began making loans in 2002, has had measurable positive impacts on zip code‐level economic outcomes. Using difference in differences and propensity score matching program evaluation techniques, we find that loans made in 2002 and 2003 under the Pilot Broadband Loan Program have had a substantial positive impact on employment, annual payroll, and the number of business establishments in recipient communities. However, a more spatially disaggregated analysis reveals that the positive economic impacts of the pilot program are driven primarily by the outcomes in communities located closest to urban areas. Finally, we find no evidence that loans received as part of the current Broadband Loan Program have had a measurable positive impact on recipient communities, possibly because not enough time has elapsed for the impacts of the current Broadband Loan Program to have emerged.
Accelerated hemolysis and neurotoxicity in neuron‐glia‐blood clot co‐cultures
Authors: Jaremko Kellie M. , Chen‐Roetling Jing , Chen Lifen , Regan Raymond F. 
Published: May 2010

J. Neurochem. (2010) 114, 1063–1073.AbstractA growing body of experimental evidence suggests that an intracerebral hematoma is toxic to neighboring cells. However, injury mechanisms remain largely undefined, due in part to conflicting results from in vivo studies. In order to investigate blood toxicity in a more controlled environment, murine clots were co‐cultured on porous membrane inserts with primary neurons and glia. Erythrocyte lysis was apparent within 48 h, but was reduced by almost 80% in cultures lacking neurons, and by over 90% in the absence of both neurons and glial cells. By 72 h, most released hemoglobin had oxidized to methemoglobin or its hemichrome degradation products. At this time point, approximately 50% of neurons were non‐viable, as detected by propidium iodide staining; glia were not injured. Deferoxamine, Trolox and the NMDA receptor antagonist MK‐801 prevented most neuronal death, but had no effect on hemolysis at neuroprotective concentrations. The 27‐fold increase in culture malondialdehyde and 5.8‐fold increase in heme oxygenase‐1 expression were also attenuated by deferoxamine and Trolox, but not by MK‐801. These results suggest that hemoglobin release from clotted blood is accelerated by adjacent neurons and glia. Subsequent neurotoxicity is mediated by both iron‐dependent and excitotoxic injury pathways.
Capability, Quality, and Performance of Offshore IS Vendors: A Theoretical Framework and Empirical Investigation
Authors: Palvia Prashant C. , King Ruth C. , Xia Weidong , Palvia Shailendra C. Jain 
Published: May 2010

ABSTRACTInformation systems (IS) offshoring has become a widespread practice and a strategic sourcing choice for many firms. While much has been written by researchers about the factors that lead to successful offshoring arrangements from the client's viewpoint, the vendor's perspective has been largely scarce. The vendor perspective is equally important as offshore IS vendors need to make important decisions in terms of delivering operational and strategic performance and aligning their resources and processes in order to meet or exceed targeted outcomes. In this article, we propose and test a three‐level capability–quality–performance (CQP) theoretical framework to understand vendor outcomes and their antecedents. The first level of the framework represents three vendor capabilities: relationship management, contract management, and information technology management. The second level has three mediating variables representing process quality: partnership, service, and deliverable quality. The third level has three dependent variables representing vendor outcomes: operational performance, strategic performance, and satisfaction. The model was tested with 188 vendor firms from India and China, the two most popular destinations for IS offshoring. Results support the CQP framework; vendor capabilities are significant predictors of intermediate quality measures, which in turn affect vendor outcomes. Implications of the study findings to both theory development and IS offshore vendor strategic decision making are discussed.
Managing Product Rollovers
Authors: Koca Eylem , Souza Gilvan C. , Druehl Cheryl T. 
Published: May 2010

ABSTRACTWe study the product rollover strategy decision, where a firm decides whether to phase out an old generation of a product to be replaced by a new with either a dual or single roll. Our model considers a final build of the old product and preannouncement of the new, and incorporates dynamic pricing and inventory decisions. We find that the optimal price path closely follows changes in reservation price curves for the two products over time. We also identify the drivers of the rollover strategy decision, finding that lower market risk (faster diffusion, higher market responsiveness to preannouncements) and higher performance improvement for the new generation are associated with the single roll strategy.
Fusion Product Planning: A Market Offering Perspective*
Authors: Chen Yuwen , Carrillo Janice E. , Vakharia Asoo J. , Sin Peter 
Published: May 2010

ABSTRACTDevices that integrate multiple functions together are popular in consumer electronic markets. We describe these multifunction devices as fusion products as they fuse together products that traditionally stand alone in the marketplace. In this article, we investigate the manufacturer's fusion product planning decision, adopting a market offering perspective that allows us to address the design and product portfolio decisions simultaneously. The general approach adopted is to develop and analyze a profit‐maximizing model for a single firm that integrates product substitution effects in identifying an optimal market offering. In the general model, we demonstrate that the product design and portfolio decisions are analytically difficult to characterize because the number of possible portfolios can be extremely large. The managerial insight from a stylized all‐in‐one model and numerical analysis is that the manufacturer should, in most cases, select only a subset of fusion and single‐function products to satisfy the market's multidimension needs. This may explain why the function compositions available in certain product markets are limited. In particular, one of the key factors driving the product portfolio decision is the margin associated with the fusion products. If a single all‐in‐one fusion product has relatively high margins, then this product likely dominates the product portfolio. Also, the congruency of the constituent single‐function products is an important factor. When substitution effects are relatively high (i.e., the product set is more congruent), a portfolio containing a smaller number of products is more likely to be optimal.