bluuebunny/crossref_metadata_2025_split huggingface dataset:
Relationship of asymmetric dimethylarginine and homocysteine to vascular aging in systemic lupus erythematosus patients
Authors: Perna Michelle , Roman Mary J. , Alpert Deborah R. , Crow Mary K. , Lockshin Michael D. , Sammaritano Lisa , Devereux Richard B. , Cooke John P. , Salmon Jane E. 
Published: February 2010

AbstractObjectiveSystemic lupus erythematosus (SLE) is independently associated with accelerated atherosclerosis and premature arterial stiffening. Asymmetric dimethylarginine (ADMA) and homocysteine are mechanistically interrelated mediators of endothelial dysfunction and correlates of atherosclerosis in the general population. The aim of this study was to assess the relationship of ADMA and homocysteine to subclinical vascular disease in patients with SLE.MethodsOne hundred twenty‐five patients with SLE who were participating in a study of cardiovascular disease underwent clinical and laboratory assessment, carotid artery ultrasonography to detect atherosclerosis, and radial artery applanation tonometry to measure arterial stiffness.ResultsNeither ADMA nor homocysteine correlated with the presence or extent of carotid atherosclerosis. In contrast, ADMA was significantly related to the arterial stiffness index. Independent correlates of arterial stiffening included the ADMA concentration, the presence of diabetes mellitus, older age at the time of diagnosis, longer disease duration, and the absence of anti‐Sm or anti‐RNP antibodies. A secondary multivariable analysis substituting homocysteine for ADMA demonstrated comparable relationships with arterial stiffness (r2 = 0.616 for homocysteine and r2 = 0.595 for ADMA).ConclusionADMA and homocysteine are biomarkers for and may be mediators of premature arterial stiffening in patients with SLE. Because arterial stiffness has independent prognostic value for cardiovascular morbidity and mortality, its predictors may identify patients who are at increased risk of cardiovascular disease.
Antiinflammatory effects of tumor necrosis factor on hematopoietic cells in a murine model of erosive arthritis
Authors: Blüml Stephan , Binder Nikolaus B. , Niederreiter Birgit , Polzer Karin , Hayer Silvia , Tauber Stefanie , Schett Georg , Scheinecker Clemens , Kollias George , Selzer Edgar , Bilban Martin , Smolen Josef S. , Superti‐Furga Giulio , Redlich Kurt 
Published: February 2010

AbstractObjectiveTo investigate the mechanisms leading to the influx of inflammatory hematopoietic cells into the synovial membrane and the role of tumor necrosis factor receptor I (TNFRI) and TNFRII in this process in an animal model of rheumatoid arthritis (RA).MethodsWe performed bone marrow transplantations in human TNF–transgenic mice using hematopoietic cells from wild‐type, TNFRI−/−, TNFRII−/−, and TNFRI/II−/− mice as donors and assessed the severity of arthritis histologically. Generation of osteoclasts from the different genotypes was analyzed in vitro and in vivo. Apoptosis was analyzed using annexin V staining as well as TUNEL assays.ResultsDespite lacking responsiveness to TNF in their hematopoietic compartment, mice not only developed full‐blown erosive arthritis but even showed increased joint destruction when compared with mice with a TNF‐responsive hematopoietic compartment. We demonstrated different roles of the 2 different TNFRs in the regulation of these processes. The absence of TNFRI on hematopoietic cells did not affect joint inflammation but markedly attenuated erosive bone destruction via reduced synovial accumulation of osteoclast precursors. In contrast, the absence of TNFRII on hematopoietic cells increased joint inflammation as well as erosive bone destruction via the regulation of osteoclast precursor apoptosis.ConclusionOur findings indicate that selective blockade of TNFRI, leaving the antiinflammatory effects of TNFRII unaltered instead of unselectively blocking TNF, might be advantageous in patients with RA.
Incidence and mortality of interstitial lung disease in rheumatoid arthritis: A population‐based study
Authors: Bongartz Tim , Nannini Carlotta , Medina‐Velasquez Yimy F. , Achenbach Sara J. , Crowson Cynthia S. , Ryu Jay H. , Vassallo Robert , Gabriel Sherine E. , Matteson Eric L. 
Published: February 2010

AbstractObjectiveInterstitial lung disease (ILD) has been recognized as an important comorbidity in rheumatoid arthritis (RA). We undertook the current study to assess incidence, predictors, and mortality of RA‐associated ILD.MethodsWe examined a population‐based incidence cohort of patients with RA and a matched cohort of individuals without RA. All subjects were followed up longitudinally. The lifetime risk of ILD was estimated. Cox proportional hazards models were used to compare the incidence of ILD between cohorts, to investigate predictors, and to explore the impact of ILD on survival.ResultsPatients with RA (n = 582) and subjects without RA (n = 603) were followed up for a mean of 16.4 and 19.3 years, respectively. The lifetime risk of developing ILD was 7.7% for RA patients and 0.9% for non‐RA subjects. This difference translated into a hazard ratio (HR) of 8.96 (95% confidence interval [95% CI] 4.02–19.94). The risk of developing ILD was higher in RA patients who were older at the time of disease onset, in male patients, and in individuals with more severe RA. The risk of death for RA patients with ILD was 3 times higher than in RA patients without ILD (HR 2.86 [95% CI 1.98–4.12]). Median survival after ILD diagnosis was only 2.6 years. ILD contributed ∼13% to the excess mortality of RA patients when compared with the general population.ConclusionOur results emphasize the increased risk of ILD in patients with RA. The devastating impact of ILD on survival provides evidence that development of better strategies for the treatment of ILD could significantly lower the excess mortality among individuals with RA.
Meta-analysis of small randomized controlled trials in surgery may be unreliable
Authors: Rerkasem K , Rothwell P M 
Published: February 2010

Abstract

Background
Meta-analysis of randomized controlled trials (RCTs) should provide reliable evidence about the effects of interventions. This may be less reliable when only small trials are available.

Methods
The sample size was determined for all surgical RCTs included in Cochrane Collaboration systematic reviews. The difficulty in interpreting meta-analysis of small trials is illustrated using two specific reviews.

Results
The typical sample size for surgical RCTs was small with a median of only 87 participants. Only 39·8 per cent had adequate prerandomization treatment allocation concealment. In both systematic reviews that were assessed in detail, statistically significant early results from meta-analysis of several small RCTs did not reliably predict the results of subsequent RCTs.

Conclusion
Surgical RCTs tend to be small and underpowered. Meta-analysis of such trials does not necessarily produce reliable results.
Studies of Amyloid‐Like Fibrillogenesis through β‐Sheet‐Mediated Self‐Assembly of Short Synthetic Peptides
Authors: Dutt Anita , Spencer Elinor C. , Howard Judith A. K. , Pramanik Animesh 
Published: February 2010

AbstractThree structurally different types of small peptides, namely, i) Boc‐Ile‐Aib‐Ile‐OMe (Aib=α‐aminoisobutyric acid), ii) Boc‐Xx‐m‐aminobenzoic acid (Xx=β‐Ala and γ‐aminobutyric acid), and iii) Boc‐Xx‐m‐nitroaniline, were found to exhibit β‐sheet‐mediated fibrillogenesis in the solid state, revealed by FT‐IR, single‐crystal X‐ray diffraction, and FE‐SEM studies. Interestingly, the fibrils grown from peptides 2 and 3 were found to bind with the physiological dye Congo red, a characteristic feature of amyloid fibrils.
Volatile Compounds from Melicope obscura
Authors: Smadja Jacqueline , Strasberg Dominique , Legoff Géraldine , Gauvin‐Bialecki Anne 
Published: February 2010

AbstractTo evaluate the interpopulation variability of volatile compounds in Melicope obscura, four samples representing four populations were collected all over the distribution area of the species in Reunion Island (Indian Ocean). The samples were extracted by hydrodistillation, and analyzed using GC/FID and GC/MS techniques. The study revealed that, in the four essential oils obtained, oxygenated sesquiterpenes were one of the major chemical classes (9.2–35.2%), mainly consisting of a new compound, (+)‐6‐ethenyl‐2‐hydroxy‐6,10‐dimethylundeca‐2,9‐dien‐4‐one (1), called melicopenol (8.6–30.1%). The compound was isolated by column chromatography and identified by spectral analyses including 1D‐ and 2D‐NMR.
ChemInform Abstract: Bonding Elucidation of the Three Common Acids H2SO4, HNO3, and HClO4.
Authors: Kalemos Apostolos , Mavridis Aristides 
Published: February 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Crystal Structure and Magnetic Properties of Li,Cr‐Containing Molybdates Li3Cr(MoO4)3, LiCr(MoO4)2 and Li1.8Cr1.2(MoO4)3.
Authors: Sarapulova A. , Mikhailova D. , Senyshyn A. , Ehrenberg H. 
Published: February 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Isothermal Section of the Er—Fe—Al Ternary System at 800 °C.
Authors: Jemmali M. , Walha S. , Pasturel M. , Tougait O. , Ben Hassen R. , Noel H. 
Published: February 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Possible Explanation for the Efficiency of Al‐Based Coatings on LiCoO2: Surface Properties of LiCo1‐xAlxO2 Solid Solution.
Authors: Daheron L. , Dedryvere R. , Martinez H. , Flahaut D. , Menetrier M. , Delmas C. , Gonbeau D. 
Published: February 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Ternary Rare Earth Rhodium Antimonides Ln6Rh30Sb19 with Ln: La—Nd, Sm, and Eu.
Authors: Jeitschko Wolfgang , Altmeyer Rainer O. , Rodewald Ute Ch. 
Published: February 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis and Solid State Structures of the Hydrogen‐Bonded Hexamolybdoplatinate(IV) Tetramer [(PtMo6O24)4H23]9‐ and the Hexamolybdoplatinate(IV) Trimers [(PtMo6O24)3H16]8‐ and [(PtMo6O24)3H14]10‐.
Authors: Day Victor W. , Goloboy James C. , Klemperer Walter G. 
Published: February 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: tert‐Alcohol‐Functionalized Imidazolium Ionic Liquid: Catalyst for Mild Nucleophilic Substitution Reactions at Room Temperature.
Authors: Shinde Sandip S. , Chi Hyung Min , Lee Byoung Se , Chi Dae Yoon 
Published: February 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: An Unprecedented Oxidative Wagner—Meerwein Transposition.
Authors: Guerard Kimiaka C. , Chapelle Clement , Giroux Marc‐Andre , Sabot Cyrille , Beaulieu Marc‐Andre , Achache Nabil , Canesi Sylvain 
Published: February 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Manganese‐Catalyzed Cross‐Coupling Reactions of Nitrogen Nucleophiles with Aryl Halides in Water.
Authors: Teo Yong‐Chua , Yong Fui‐Fong , Poh Chai‐Yun , Yan Yaw‐Kai , Chua Guan‐Leong 
Published: February 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: A Versatile Synthesis of Various Substituted Taurines from Vicinal Amino Alcohols and Aziridines.
Authors: Chen Ning , Jia Weiyi , Xu Jiaxi 
Published: February 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Cyclopropylation of Arylamines at the 2‐Position with Cyclopropylmagnesium Carbenoids.
Authors: Yamada Yukie , Mizuno Mirai , Nagamoto Shinobu , Satoh Tsuyoshi 
Published: February 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Enantioselective Synthesis of Quaternary Stereogenic Centers Through Catalytic Asymmetric Addition of Dimethylzinc to α‐Ketoesters with Chiral cis‐Cyclopropane‐Based Amide Alcohol as Ligand.
Authors: Zheng Bing , Hou Shicong , Li Zhiyuan , Guo Hongchao , Zhong Jiangchun , Wang Min 
Published: February 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis of 4‐Substituted Styrene Compounds via Palladium Catalyzed Suzuki—Miyaura Reaciton Using Bidentate Schiff Base Ligands.
Authors: Liu Yan , Wang Jinqu 
Published: February 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: PdCl2‐Promoted Electrophilic Annulation of 2‐Alkynylphenol Derivatives with Disulfides or Diselenides in the Presence of Iodine.
Authors: Du Hui‐Ai , Zhang Xing‐Guo , Tang Ri‐Yuan , Li Jin‐Heng 
Published: February 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis of a New Spiro‐BOX Ligand and Its Application in Enantioselective Allylic Cyclization Based on Carbopalladation of Allenyl Hydrazines.
Authors: Shu Wei , Ma Shengming 
Published: February 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Microwave‐Assisted Organocatalytic Multicomponent Knoevenagel/Hetero Diels—Alder Reaction for the Synthesis of 2,3‐Dihydropyran[2,3‐c]pyrazoles.
Authors: Radi Marco , Bernardo Vincenzo , Bechi Beatrice , Castagnolo Daniele , Pagano Mafalda , Botta Maurizio 
Published: February 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: A One‐Pot Synthesis of 2‐Aryl‐4,5‐anti‐diphenyloxazolines.
Authors: Clayden Jonathan , Clayton James , Harvey Rebecca A. , Karlubikova Ol'ga 
Published: February 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Copper‐Catalyzed Efficient Multicomponent Reaction: Synthesis of Benzoxazoline‐Amidine Derivatives.
Authors: Shang Yongjia , He Xinwei , Hu Jinsong , Wu Jianwei , Zhang Min , Yu Shuyan , Zhang Qianqian 
Published: February 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Microwave Assisted Synthesis and Antimicrobial Activity of Some 2‐(Benzofuran‐2‐yl)‐7‐(substituted)imidazo[2,1‐b]benzothiazoles.
Authors: Rani Rekha , Makrandi J. K. 
Published: February 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Electron Transfer‐Induced Aromatization of 1,4‐Dihydropyridines.
Authors: Memarian Hamid R. , Ghazaie Marieh , Mehneh Somayeh Kakhki 
Published: February 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Formal Alkyne Aza‐Prins Cyclization: Gold(I)‐Catalyzed Cycloisomerization of Mixed N,O‐Acetals Generated from Homopropargylic Amines to Highly Substituted Piperidines.
Authors: Kim Cheoljae , Bae Hyo Jin , Lee Ji Hyung , Jeong Wook , Kim Haejin , Sampath Vasu , Rhee Young Ho 
Published: February 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Quinolines from Morita—Baylis—Hillman Acetates of 2‐Azidobenzaldehydes.
Authors: Han Eun‐Gu , Kim Hea Jung , Lee Kee‐Jung 
Published: February 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Heteroaromatic Sulfonates and Phosphates as Electrophiles in Iron‐Catalyzed Cross‐Couplings.
Authors: Goegsig Thomas M. , Lindhardt Anders T. , Skrydstrup Troels 
Published: February 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Rh(II)‐Catalyzed Reactions of 2H‐Azirines with Ethyl 2‐Acyl‐2‐diazoacetates. Synthesis of Novel Photochromic Oxazines.
Authors: Khlebnikov Vsevolod A. , Novikov Mikhail S. , Khlebnikov Alexander F. , Rostovskii Nikolai V. 
Published: February 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Efficient Synthesis of Nevirapine Analogues to Study Its Metabolic Profile by Click Fishing.
Authors: Bernard Sylvain , Defoy Daniel , Dory Yves L. , Klarskov Klaus 
Published: February 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: The Soft Nucleophilicity of Organotellurolates Driving the SN2‐Type Lactone Ring‐Opening Reaction.
Authors: Silva Marcio S. , Dos Santos Alcindo A. , Comasseto Joao V. 
Published: February 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: A One‐Pot Reaction for Biorefinery: Combination of Solid Acid and Base Catalysts for Direct Production of 5‐Hydroxymethylfurfural from Saccharides.
Authors: Takagaki Atsushi , Ohara Mika , Nishimura Shun , Ebitani Kohki 
Published: February 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Solid‐State Synthesis of Magnesium‐Based Functional Alloys and Compounds
Authors: Aizawa T. 
Published: February 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.