bluuebunny/crossref_metadata_2025_split huggingface dataset:
Chronic Administration of Red Yeast Rice Mitigates Endothelial Dysfunction in Spontaneously Hypertensive Rats by Inhibiting Oxidative Stress and Endothelial Nitric Oxide Synthase Uncoupling
Authors: Tan Jiunn Jye , Murugan Dharmani Devi , Ling Wei Chih , Lee Siew-Keah , Kang Waye Hann 
Published: June 2024

Background:
Hypertension is associated with endothelial dysfunction. An imbalance in
the production of Nitric Oxide (NO) and Reactive Oxygen Species (ROS), leading to impaired
NO-cyclic Guanosine Monophosphate (cGMP) pathway, contributes to this disorder. Red Yeast
Rice (RYR), produced from the fermentation of rice with Monascus purpureus, is a traditional
functional food originating from China. Although recognized for its anti-dyslipidemia properties,
there has been growing evidence regarding the anti-hypertensive effects of RYR. However, these
studies only focused on its direct and short-term effects.

Aim:
This study aims to investigate the vasoprotective effects of chronic oral RYR administration
using Spontaneously Hypertensive Rats (SHR).

Materials and Methods:
SHR were randomly divided into 3 groups: SHR – Control; SHR – RYR
extract (100 mg/kg/day); SHR – lovastatin (10 mg/kg/day). Wistar-Kyoto Rats (WKY) were used
as normotensive controls. All animals were treated for 12 weeks by oral gavage. Systolic Blood
Pressure (SBP) was measured weekly (tail-cuff method). Vascular reactivity was determined using
isolated rat aortic rings in an organ bath. Aortic ROS, NO, tetrahydrobiopterin (BH4), and
cGMP levels were evaluated.

Results:
Administration of RYR attenuated SBP elevation and enhanced endothelium-dependent
vasodilation in aortic rings. In addition, RYR decreased ROS production and significantly improved
the level of vascular NO, BH4, and cGMP.

Conclusion:
In an SHR model, treatment with RYR for 12 weeks exerts an SBP lowering effect
that can be attributed to improved vascular function via reduction of oxidative stress, decreased endothelial
NO Synthase (eNOS) uncoupling and enhanced NO-cGMP pathway.
Luminescence Detection of Cr3+, Bi3+, and Acetone in Aqueous Solution by Core-Shell Tb-MOF
Authors: Yang Mengfei , Shi Jing , Luo Taiming , Yang Xiaozhan 
Published: June 2024

Aims:
By using terephthalic acid, 2, 5-furandicarboxylic acid, and terbium nitrate
hexahydrate, a Tb-MOF with a core-shell structure was successfully designed and prepared.

Method:
A one-pot method was employed to design and synthesize core-shell Tb-MOF. The
morphology, luminescence performance, and stability were well characterized.

Results:
Tb-MOF demonstrated good water stability, acid and alkali resistance, and thermal stability.
Tb-MOF was found to have high sensitivity to detect Cr3+, Bi3+, and acetone in an aqueous solution,
and the LOD of Cr3+, Bi3+, and acetone were calculated to be 0.18 μM, 4.22 μM, and 0.26%,
respectively. The sensing mechanism of Cr3+ and acetone was explained as energy-competitive
absorption, and the sensing mechanism of Bi3+ was explained as ion replacement.

Conclusion:
The prepared Tb-MOF can be developed as a multifunctional light-emitting sensor with
high selectivity.
Clinical Manifestations’ Spectrum of Smartphone Addiction: Moving from an Addiction toward a Clinical Syndrome
Authors: Alwazzeh Mudar , Harfouch Muhdammad , Hasan Manal Ahmed , Alqatari Safi , AlSaid Abir Hamad , Alwazzeh Marwan Jabr 
Published: June 2024

Background
Smartphone addiction is an emerging type of addiction in the digital era, characterized by smartphone dependence that negatively affects human health with a wide range of psychological and physical manifestations.

Objective
This study aimed to evaluate the detailed clinical manifestations of smartphone addiction as a delineated clinical syndrome.

Methods
A cross-sectional study design was employed to assess smartphone addiction prevalence and its health impacts among Syrian undergraduates using the Smartphone Addiction Scale-Short Version (SAS-SV 2013), the Kessler psychological distress scale (K-6), and a comprehensive assessment of the clinical manifestations frequently linked to smartphone addiction in the literature. Different statistical modeling techniques were applied; a P value of < .05 was considered statistically significant.

Results
Of 1532 invited undergraduates, 1401 (91.45%) completed the assessment adequately. Most participants were females (59.7%) and below 23 years of age (73.2%). The prevalence of smartphone addiction was 67.80%; statistically significant smartphone addiction associations were revealed with psychological distress (P < .0001) with odds ratios of 3.308. Most screened physical manifestations also showed a significant association with smartphone addiction.

Conclusion
A high prevalence of smartphone addiction was observed with a broad spectrum of associated mental and physical manifestations. As smart device addiction becomes a global health concern, combining the clinical findings reported in the related literature into one clinical identity is necessary to develop a holistic management approach for the delineated clinical syndrome.
Entrada na Escola como Professor
Authors: Rodrigues Pessoa Amanda Raquel , De Souza Castro Iris Martins , Lima Costa Sandy 
Published: June 2024

O artigo objetiva discutir a inserção profissional de iniciantes na Educação Básica, por meio de uma experiência compartilhada. Recorre-se a resultados da pesquisa em rede Pesquisa COM Professores Iniciantes: um estudo sobre indução profissional que assume como desenho metodológico a pesquisa narrativa, na perspectiva do narrar enquanto atividade (auto)biográfica, que se traduz em pesquisa-formação. As narrativas indicam situações onde há a presença de acolhimento entre os pares, como também casos em que a ausência de cuidado se destacou na entrada na profissão, gerando uma repercussão no processo de identificação com a docência. Com efeito, os achados oferecem um caminho para pensar o processo de indução profissional.
Piloting the Inclusion of the Key Populations Unique Identifier Code in the South African Routine Health Information Management System: Protocol for a Multiphased Study
Authors: Rampilo Mashudu , Phalane Edith , Phaswana-Mafuya Refilwe Nancy 
Published: June 2024

Background
The global community has set an ambitious goal to end HIV/AIDS as a public health threat by 2030. Significant progress has been achieved in pursuing these objectives; however, concerns remain regarding the lack of disaggregated routine data for key populations (KPs) for a targeted HIV response. KPs include female sex workers, transgender populations, gay men and other men who have sex with men, people who are incarcerated, and people who use drugs. From an epidemiological perspective, KPs play a fundamental role in shaping the dynamics of HIV transmission due to specific behaviors. In South Africa, routine health information management systems (RHIMS) do not include a unique identifier code (UIC) for KPs. The purpose of this protocol is to develop the framework for improved HIV monitoring and programming through piloting the inclusion of KPs UIC in the South African RHIMS.

Objective
This paper aims to describe the protocol for a multiphased study to pilot the inclusion of KPs UIC in RHIMS.

Methods
We will conduct a multiphased study to pilot the framework for the inclusion of KPs UIC in the RHIMS. The study has attained the University of Johannesburg Research Ethics Committee approval (REC-2518-2023). This study has four objectives, including a systematic review, according to the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines (objective 1). Second, policy document review and in-depth stakeholder interviews using semistructured questionnaires (objective 2). Third, exploratory data analysis of deidentified HIV data sets (objective 3), and finally, piloting the framework to assess the feasibility of incorporating KPs UIC in RHIMS using findings from objectives 1, 2, and 3 (objective 4). Qualitative and quantitative data will be analyzed using ATLAS.ti (version 6; ATLAS.ti Scientific Software Development GmbH) and Python (version 3.8; Python Software Foundation) programming language, respectively.

Results
The results will encompass a systematic review of literature, qualitative interviews, and document reviews, along with exploratory analysis of deidentified routine program data and findings from the pilot study. The systematic review has been registered in PROSPERO (International Prospective Register of Systematic Reviews; CRD42023440656). Data collection is planned to commence in September 2024 and expected results for all objectives will be published by December 2025.

Conclusions
The study will produce a framework to be recommended for the inclusion of the KP UIC national rollout. The study results will contribute to the knowledge base around the inclusion of KPs UIC in RHIMS data.

Trial Registration
PROSPERO CRD42023440656; https://tinyurl.com/msnppany

International Registered Report Identifier (IRRID)
PRR1-10.2196/55092
Combustion of Sugarcane Bagasse Pellets Produced with/without Glycerol: Chemical, Thermal and Emission Analyses
Authors: Santos Gilvan R. , Moreira Fabricianny L. , Araujo Rinaldo S. , Oliveira Mona Lisa M. , Cavalcante Francisco S.A. , Serra Daniel S. 
Published: June 2024

Purpose: Use of agricultural biomass in the form of pellets has gained worldwide prominence in recent decades, as part of the search for cleaner and renewable energy sources. Brazil is the largest sugarcane producer in the world, a fact that also places it as a major producer of residues from processing this crop. Methods: In this study, sugarcane bagasse pellets (SBP100) were handcrafted using glycerol as binder (30% - SBP30G) and, subsequently, analyses of their chemical and thermal properties, as well as those of the thermal decomposition exhaust gases, were conducted. Results: Average temperatures in the combustion range were 213.62±137.07° C (SBP100) and 211.97±86.85 °C (SBP30G). Combustion exhaust gas values were 20.04±0.15% (SBP100) and 19.95±0.19% (SBP30G) for O2; 1739.58±156.17 ppm (SBP100) and 1575±466.85 ppm (SBP30G) for CO; 19.92 ± 2.47 ppm (SBP100) and 17.33±4.69 ppm (SBP30G) for NOx; 341.67±134.37 ppm (SBP100) and 491.67±341.42 ppm (SBP30G) for CH4. SBP30G combustion proved to be less polluting with respect to CO and NOx generation than SBP100, but not for CH4. However, average thermal performance was similar for both. Conclusion: Use of glycerol contributed considerably to the changes in the pellets’ physical parameters. Exhaust gas analyses of the combustion of these substrates can serve as a basis for creating safety parameters and public policies to regulate the use of biomass for energy purposes.
Modeling the distribution of industrial enterprise products in hierarchical transport and logistics systems
Authors: Гончаренко С.Н. , Марзуг А.А.Ф. 
Published: June 2024

В работе произведено сценарное моделирование маршрутов доставки продукции промышленного предприятия автомобильным и железнодорожным транспортном с учетом перевалки на промежуточных транспортно-логистических терминалах, времени доставки, расстояния и различных типов используемых транспортных средств. На основе сформированного графика поставок моделируется необходимое количество рейсов с учетом сезонных ограничений, а также производится расчет необходимого транспортного ресурса и суммарных затрат на перевозку готовой продукции.
The paper carries out a scenario modeling of routes for delivering products of an industrial enterprise by road and rail, taking into account transshipment at intermediate transport and logistics terminals, delivery time, distance and various types of vehicles used. Based on the generated delivery schedule, the required number of flights is modeled, considering seasonal restrictions, the authors calculate required transport resource and total costs for transporting finished products.
Design of mechanisms for the implementation of interlevel teacher training programs in the education system «secondary vocational education – higher education»
Authors: Иванова Н.В. , Яковлева Е.В. , Виноградова М.А. 
Published: June 2024

В статье актуализируется проблема поиска механизмов построения преемственного межуровневого педагогического образования. Представлены этапы реализации межуровневых программ в системе СПО и ВО. Научной значимостью исследования является определение и структурирование механизмов реализации межуровневых образовательных программ для поддержки векторов «Ускорение» и «Зона ближайшего развития», обеспечивающих преемственность подготовки педагогических кадров. Раскрыта авторская позиция содержательного наполнения выделенных механизмов и технологических инструментов их реализации.
The article highlights the problem of mechanisms for building continuity of interlevel pedagogical education. The authors present the implementation stages of interlevel programmes in the system of SVE and HE. The scientific significance of the research is the definition and structuring of mechanisms for the implementation of interlevel educational programmes to support the vectors “Acceleration” and “Zone of proximal development” that ensure the continuity of teacher training. The article reveals the authors' position related to the content of the selected mechanisms and technological tools for their implementation.
Modeling the payment process for the activities of an insurance medical organization based on a Petri net
Authors: Швецов А.Н. , Кочкин Д.В. , Дубова Д.А. 
Published: June 2024

В статье рассматривается процесс оплаты страховых случаев лечения – услуг оказанных в бюджетной медицинской организации. Авторами предложена модель процесса оплаты страховых случаев лечения на базе аппарата раскрашенных сетей Петри. Модель позволяет оценить временные затраты на различных этапах обработки и может быть использована для анализа и модификации процесса оплаты. По результатам проведенного эксперимента сделан вывод об адекватности разработанной модели.
The article discusses the process of paying for insurance cases of treatment provided in a budget medical organization. The authors propose a model of payment for insurance cases of treatment based on the apparatus of colored Petri nets. The model allows estimating the time expenditures at various stages of processing and can be used to analyze and modify the payment process. Based on the results of the experiment, a conclusion was made about the adequacy of the developed model.
The main pragmatic functions of code-switching in the English novel “Jeeves in the offing” by P. G. Wodehouse
Authors: Гунько Л.А. 
Published: June 2024

В статье рассматриваются основные прагматические функции переключений кодов в англоязычном романе П. Г. Вудхауза «Дживс в отпуске». Матричным языком произведения является английский, а гостевыми – французский и латинский. Переключения кодов выполняют четыре прагматических функции в произведении: предметно-тематическую, цитатную, самоидентификации и эмфатическую. Ключевые слова: переключение кода (ПК), матричный язык, гостевой язык, художественный билингвизм, билингвальный персонаж, билингвальная речь
This article considers the main pragmatic functions of code-switching in the English novel “Jeeves in the offing” written by P. G. Wodehouse. As the result of our research, we reveal certain features of the code-switching usage in the book. The Matrix language of bilingual utterances is English and the Embedded languages are French and Latin. The author of the article argues that the most common pragmatic function in the bilingual characters’ speech is the message-oriented one. Emotional, emphatic and citation functions are also represented.
Mikolka's “Theory” and its origins in the artistic space of F. M. Dostoevsky's novel “Crime and Punishment”
Authors: Карпачева Т.С. 
Published: June 2024

В статье рассматривается образ красильщика Миколки в романе Ф. М. Достоевского «Преступление и наказание» и соответствие его идеи о спасительности страдания идеологии секты бегунов. Как установил следователь Порфирий Петрович, эту идею внушил Миколке старец, под началом которого тот жил в деревне, т. е., скорее всего, здесь идет речь об альтернативной религиозной общине сектантского толка, близкой к бегунам. Мировоззрение Миколки подтверждается и судебной практикой, отраженной в воспоминаниях современников Достоевского. На основании исторических источников была выявлена сходная с Миколкиной малочисленная секта под руководством крестьянина Козьмы Карпова. Идея, пропагандируемая учителем Миколки, соотносится с теорией Раскольникова, где нивелируется ценность человеческой жизни. Миколка не совершает убийства, но, следуя идее «страдания от властей», готов погубить себя. С другой стороны, нельзя не заметить, что теория Раскольникова лежит в основе любого сектантского учения, утверждающего «избранность» одних, которым «все позволено», и «обыкновенность» других. Все это позволяет говорить об авторском отношении к подобного рода сектам, культивирующим идею страдания и пропагандирующим асоциальный образ жизни. Культ страдания оказывается разрушительным для личности и общества, а не созидательным.
The article examines the image of the dyer Mikolka in F. M. Dostoevsky's novel "Crime and Punishment" and the correspondence of his idea of salvation through suffering to the ideology of runners' cult. As the investigator Porfiry Petrovich established, this idea was put into Mikolka’s head by an elder, under whom he lived in the village, and most likely, here we are talking about an alternative religious community of a sectarian kind close to runners. Mikolka's worldview is also confirmed by judicial practice reflected in the memoirs of Dostoevsky's contemporaries. Based on historical sources, a small sect similar to the Mikolka's was identified under the leadership of the peasant Kozma Karpov. The idea promoted by Mikolka's "teacher" correlates with Raskolnikov's theory, where the value of human life is ignored. Mikolka does not commit murder, but, following the idea of "suffering from the authorities," he is ready to ruin himself. On the other hand, it is impossible not to notice that Raskolnikov's theory underlies any sectarian doctrine that asserts the "selectness" of some, to whom "everything is allowed", and the "ordinariness" of others. All this allows us to talk about the author's attitude to such sects, cultivating the idea of suffering and promoting an antisocial lifestyle. The cult of suffering turns out to be destructive for the individual and society, rather than constructive. Keywords: Dostoevsky, “Crime and punishment”, Mikolka, runners, sect
PENGARUH BEDA WAKTU TANAM TUMPANGSARI SINGKONG-SORGUM PADA PERTUMBUHAN, PRODUKSI, DAN VIABILITAS BENIH PASCASIMPAN DELAPAN BULAN EMPAT GENOTIPE SORGUM (Sorghum bicolor [L.] Moench)
Authors: Pramono Eko , Hadi Muhammad Syamsoel , Ermawati Ermawati , Maula Lutfiatul 
Published: June 2024

Salah satu faktor yang berpengaruh pada pertumbuhan dan produksi pada pertanaman sistem tumpangsari adalah beda waktu tanam antara dua jenis tanaman. Penelitian ini bertujuan untuk mengetahui pengaruh beda waktu tanam dari tumpangsari sorgum-singkong pada pertumbuhan, produksi, dan viabilitas benih pascasimpan dari empat genotipe sorgum. Penelitian dilaksanakan di Desa Karang Endah, Kecamatan Jati Agung, Kabupaten Lampung Selatan (5.28°LS 105.27°BT) dengan ketinggian 82,3 mdpl dan di Laboratorium Benih dan Pemuliaan Tanaman Fakultas Pertanian, Universitas Lampung pada Januari 2019 sampai Juni 2020. Percobaan menggunakan rancangan perlakuan faktorial 2x4 yang diacak secara lengkap dalam petak berjalur (strip plot) dengan tiga ulangan dalam tiga blok. Petak utama yaitu beda waktu tanam yang terdiri dari nol minggu dan dua minggu. Anak petak yaitu empat genotipe sorgum yang terdiri dari Super 1, GH-6, Suri dan GH-12. Hasil penelitian menunjukkan bahwa beda waktu tanam berpengaruh nyata pada pertumbuhan, produksi dan viabilitas pascasimpan pada variabel bobot kering brangkasan atas, bobot benih per malai, jumlah benih per malai dan kecambah normal kuat. Genotipe berpengaruh nyata pada viabilitas benih pascasimpan kecambah normal total dan kecambah normal kuat. Pengaruh genotipe sorgum terhadap produksi tergantung dari waktu tanam.
Mapping of Land Suitability for Growing Tobacco (Nicotiana tabacum L.) Under Various Slope Using Geographic Information Systems
Authors: Mujiyo Mujiyo , Irawaningsih Daradinda Surya , Minardi Slamet , Cahyono Ongko 
Published: June 2024

The study aims to identify the classes and the determinant factors of land suitability of Tobacco in order to provide recommendations for land management as an effort in increasing the development of Tobacco in Eromoko District, Wonogiri Regency, Indonesia. This research used a descriptive-exploratory approach by field surveys, laboratory analysis, and matching the data with growth requirement characteristics for Tobacco crops. The field survey was carried out based on a working map, namely the Land Mapping Unit (LMU), overlaid maps of soil type, slope, and rainfall. Research results illustrated that 18 LMUs were included in the marginally suitable class (S3) (4,968.78 ha, about 51% of research area) with limiting factors wa; oa; nr; na; eh, and 8 LMUs were included in the unsuitable class (N) (4,919.11 ha, about 49% of research area) with limiting factors N and eh. This study provide information about the land suitability class and the limiting factors each area to determine the potential success of Tobacco cultivation and make suitable improvement efforts. Keywords: Hilly land, Land management, Limiting factors, Sustainable agriculture, Tobacco growth potential.
Eksergijska analiza i poboljšanje performansi potkritičnog ORC za korištenje izduvnih plinova iz bioplinskog CHP
Authors: Ćehajić Nurdin , Fejzić Jasmin 
Published: June 2024

U radu je dizajniran i analiziran potkritični regenerativni organski Rankinov ciklus (rORC) za korištenje otpadne toplote iz bioplinskog kogeneracijskog postrojenja (CHP). Dizajnirani rORC u sprezi sa bioplinskim CHP čini hibridni sistem. Na taj način se povećava stepen efikasnosti kroz generisanje dodatne električne i toplotne energije u potkritičnom rORC. Bioplin za bioplinsko CHP je proizveden na farmi muznih krava prvenstveno iz stajnjaka anaerobnom digestijom u fermentoru. Za analizu rORC izabrani su radni fluiditoluen i m-ksilen, koji nakon obavljenog rada moraju zadovoljiti okolišne, sigurnosne i termodinamičke kriterije. Razmatrana su dva scenarija. Prvi scenarij je kada rORC koristi izduvne plinove iz bioplinskog CHP temperature 260 °C i masenog protoka 0,25 kg/s, nakon što su izduvni plinovi u razmjenjivaču plin/voda = 440 °C/85 °C generisali 57 kWt koja se koristi za grijanje supstrata u fermentoru. U drugom scenariju potkritični rORC koristi izduvne plinove temperature 440 °C i masenog protoka 0,25 kg/s. Parametarska analiza i optimizacija će za oba scenarija obuhvatiti neto proizvedene snage, eksergijske efikasnosti, masene protoke, toplotne snage i snage pumpi potkritičnog rORC za maksimalne vrijednosti pritiska i temperature radnih fluida na ulazu u turbinu, uzimajući u obzir sigurnosna i termodinamička ograničenja njihove upotrebe za dati izvor toplote.