bluuebunny/crossref_metadata_2025_split huggingface dataset:
A retrospective analysis of drugs associated with the development of cutaneous squamous cell carcinoma reported by patients on the FDA’s adverse events reporting system
Authors: Jean-Pierre Philippe , Nouri Keyvan 
Published: May 2024

AbstractCutaneous squamous cell carcinoma (cSCC) is the second most common type of skin cancer arising from squamous cells of the epidermis. Most cases of cSCC have a good prognosis if detected and treated early; however, certain cases can be aggressive. The primary risk factor for cSCC is prolonged ultraviolet radiation from sun exposure, leading to DNA mutations. Other risk factors have also been observed, including adverse reactions to medications, particularly immunosuppressants. A query of the Food and Drug Administration Adverse Events Reporting System (FAERS) was done, and all reported events of cSCC as adverse events to medication were recorded along with demographic data of patients affected. A total of 4,792 cases of cSCC as an adverse event to medication were reported between 1997 and 2023. Lenalidomide, a chemotherapeutic drug, had the most cases of cSCC as an adverse event. Nine of the top 10 drugs associated with cSCC had immunosuppressive characteristics. While males had higher odds of cSCC associated with corticosteroids and calcineurin inhibitors, females had higher odds of cSCC related to monoclonal antibodies. Geriatric patients accounted for the majority of cSCC cases at 59.7%. Drawing on data from the FAERS database, there’s been a consistent increase in cSCC cases as a side-effect to certain medications, with most having immunosuppressive characteristics. Since there is a lack of up-to-date literature overviewing the most implicated medications for cSCC, we aimed to illustrate this better, as well as patient demographics, to better guide clinicians when prescribing these medications.
Development of a 3D-printed nuchal translucency model: a pilot study for prenatal ultrasound training
Authors: Recker Florian , Remmersmann Laura , Jost Elena , Jimenez-Cruz Jorge , Haverkamp Nicolas , Gembruch Ulrich , Strizek Brigitte , Schäfer Valentin S. 
Published: May 2024

AbstractBackgroundWe used two 3D ultrasound volumes of fetal heads at 13 weeks to create live-size 3D-printed phantoms with a view to training or assessment of diagnostic abilities for normal and abnormal nuchal translucency measurements. The phantoms are suitable for use in a water bath, imitating a real-life exam. They were then used to study measurement accuracy and reproducibility in examiners of different skill levels.MethodsUltrasound scans of a 13 + 0-week fetus were processed using 3D Slicer software, producing a stereolithography file for 3D printing. The model, crafted in Autodesk Fusion360™, adhered to FMF guidelines for NT dimensions (NT 2.3 mm). Additionally, a model with pathologic NT was designed (NT 4.2 mm). Printing was performed via Formlabs Form 3® printer using High Temp Resin V2. The externally identical looking 3D models were embedded in water-filled condoms for ultrasound examination. Eight specialists of varying expertise levels conducted five NT measurements for each model, classifying them in physiological and abnormal models.ResultsClassification of the models in physiological or abnormal NT resulted in a detection rate of 100%. Average measurements for the normal NT model and the increased NT model were 2.27 mm (SD ± 0.38) and 4.165 mm (SD ± 0.51), respectively. The interrater reliability was calculated via the intraclass correlation coefficient (ICC) which yielded a result of 0.883, indicating robust agreement between the raters. Cost-effectiveness analysis demonstrated the economical nature of the 3D printing process.DiscussionThis study underscores the potential of 3D printed fetal models for enhancing ultrasound training through high inter-rater reliability, consistency across different expert levels, and cost-effectiveness. Limitations, including population variability and direct translation to clinical outcomes, warrant further exploration. The study contributes to ongoing discussions on integrating innovative technologies into medical education, offering a practical and economical method to acquire, refine and revise diagnostic skills in prenatal ultrasound. Future research should explore broader applications and long-term economic implications, paving the way for transformative advancements in medical training and practice.
Felix Klein’s early contributions to anschauliche Geometrie
Authors: Rowe David E. 
Published: May 2024

AbstractBetween 1873 and 1876, Felix Klein published a series of papers that he later placed under the rubric anschauliche Geometrie in the second volume of his collected works (1922). The present study attempts not only to follow the course of this work, but also to place it in a larger historical context. Methodologically, Klein’s approach had roots in Poncelet’s principle of continuity, though the more immediate influences on him came from his teachers, Plücker and Clebsch. In the 1860s, Clebsch reworked some of the central ideas in Riemann’s theory of Abelian functions to obtain complicated results for systems of algebraic curves, most published earlier by Hesse and Steiner. These findings played a major role in enumerative geometry, whereas Plücker’s work had a strongly qualitative character that imbued Klein’s early studies. A leitmotif in these works can be seen in the interplay between real curves and surfaces as reflected by their transformational properties. During the early 1870s, Klein and Zeuthen began to explore the possibility of deriving all possible forms for real cubic surfaces as well as quartic curves. They did so using continuity methods reminiscent of Poncelet’s earlier approach. Both authors also relied on visual arguments, which Klein would later advance under the banner of intuitive geometry (anschauliche Geometrie).
Stressful crystal histories recorded around melt inclusions in volcanic quartz
Authors: Cadena Tyler , Manga Michael , Befus Kenneth , Tamura Nobumichi 
Published: May 2024

AbstractMagma ascent and eruption are driven by a set of internally and externally generated stresses that act upon the magma. We present microstructural maps around melt inclusions in quartz crystals from six large rhyolitic eruptions using synchrotron Laue X-ray microdiffraction to quantify elastic residual strain and stress. We measure plastic strain using average diffraction peak width and lattice misorientation, highlighting dislocations and subgrain boundaries. Quartz crystals across studied magma systems preserve similar and relatively small magnitudes of elastic residual stress (mean 53–135 MPa, median 46–116 MPa) in comparison to the strength of quartz (~ 10 GPa). However, the distribution of strain in the lattice around inclusions varies between samples. We hypothesize that dislocation and twin systems may be established during compaction of crystal-rich magma, which affects the magnitude and distribution of preserved elastic strains. Given the lack of stress-free haloes around faceted inclusions, we conclude that most residual strain and stress was imparted after inclusion faceting. Fragmentation may be one of the final strain events that superimposes stresses of ~ 100 MPa across all studied crystals. Overall, volcanic quartz crystals preserve complex, overprinted deformation textures indicating that quartz crystals have prolonged deformation histories throughout storage, fragmentation, and eruption.
Brittle initiation of dissolution–precipitation creep in plagioclase-rich rocks: insights from the Bergen arcs, Norway
Authors: Moore Jo , Piazolo Sandra , Beinlich Andreas , Austrheim Håkon , Putnis Andrew 
Published: May 2024

AbstractThe initiation of ductile shear zones commonly occurs spatially associated with fluid-rock reactions along brittle precursors. In many cases the relative timing of fracturing, fluid infiltration, reaction, and recrystallisation is unclear, making it difficult to disentangle mechanisms of shear zone initiation from subsequent deformation and recrystallisation. Here we present the study of the transition from a dry plagioclase-diopside-garnet-scapolite host granulite-facies lithology to (1) a low strain amphibolite-facies rock, and (2) a transition from low strain to high strain amphibolite-facies lithologies. Hydration of the granulite-facies precursor at amphibolite-facies conditions produces an assemblage comprised dominantly of plagioclase-amphibole-zoisite-clinozoisite-kyanite-scapolite-quartz. Detailed study of plagioclase chemistry and microstructures across these two transitions using Electron Backscatter Diffraction (EBSD) and Wavelength Dispersive Spectrometry (WDS) allows us to assess the degree of coupling between deformation and fluid-rock reaction across the outcrop. Plagioclase behaves dominantly in a brittle manner at the hydration interface and so the initial weakening of the rock is attributed to grain size reduction caused by fracture damage and fluid infiltration at amphibolite-facies conditions. Extensive fracturing-induced grain size reduction locally increases permeability and allows for continuing plagioclase and secondary mineral growth during shear. Based on plagioclase microstructures, such as, an inherited but dispersed crystallographic preferred orientation (CPO), truncation of chemical zoning, and the dominance of fine (5–150 µm), slightly elongate, polygonal grains we conclude that deformation is dominantly facilitated by dissolution–precipitation creep assisted by grain boundary sliding in the shear zone.
Outcome prediction of SSTR-RADS-3A and SSTR-RADS-3B lesions in patients with neuroendocrine tumors based on 68Ga-DOTATATE PET/MR
Authors: Gao Jing , Zhou Jinxin , Liu Chang , Pan Yu , Lin Xiaozhu , Zhang Yifan 
Published: May 2024

Abstract
Purpose
Somatostatin receptor (SSTR)-targeted PET imaging has emerged as a common approach to evaluating those patients with well-differentiated neuroendocrine tumors (NETs). The SSTR reporting and data system (SSTR-RADS) version 1.0 provides a means of categorizing lesions from 1 to 5 according to the likelihood of NET involvement, with SSTR-RADS-3A (soft-tissue) and SSTR-RADS-3B (bone) lesions being those suggestive of but without definitive NET involvement. The goal of the present study was to assess the ability of 68Ga-DOTATATE PET/MR imaging data to predict outcomes for indeterminate SSTR-RADS-3A and 3B lesions.

Methods
NET patients with indeterminate SSTR-RADS-3A or SSTR-RADS-3B lesions who underwent 68Ga-DOTATATE PET/MR imaging from April 2020 through August 2023 were retrospectively evaluated. All patients underwent follow-up through December 2023 (median, 17 months; (3–31 months)), with imaging follow-up or biopsy findings ultimately being used to classify lesions as malignant or benign. Lesion maximum standardized uptake value (SUVmax) along with minimum and mean apparent diffusion coefficient (ADCmin and ADCmean) values were measured and assessed for correlations with outcomes on follow-up.

Results
In total, 33 indeterminate SSTR-RADS-3 lesions from 22 patients (19 SSTR-RADS-3A and 14 SSTR-RADS-3B) were identified based upon baseline 68Ga-DOTATATE PET/MR findings. Over the course of follow-up, 16 of these lesions (48.5%) were found to exhibit true NET positivity, including 9 SSTR-RADS-3A and 7 SSTR-RADS-3B lesions. For SSTR-RADS-3A lymph nodes, a diameter larger than 0.7 cm and an ADCmin of 779 × 10−6mm2/s or lower were identified as being more likely to be associated with metastatic lesions. Significant differences in ADCmin and ADCmean were identified when comparing metastatic and non-metastatic SSTR-RADS-3B bone lesions (P < 0.05), with these parameters offering a high predictive ability (AUC = 0.94, AUC = 0.86).

Conclusion
Both diameter and ADCmin can aid in the accurate identification of the nature of lesions associated with SSTR-RADS-3A lymph nodes, whereas ADCmin and ADCmean values can inform the accurate interpretation of SSTR-RADS-3B bone lesions.
Low skeletal muscle mass predicts melanoma-specific survival in melanoma patients treated with adjuvant immune checkpoint blockade
Authors: Mengoni Miriam , Braun Andreas Dominik , Hinnerichs Mattes Simon , Aghayev Anar , Tüting Thomas , Surov Alexey 
Published: May 2024

Abstract
Purpose
Adjuvant immunotherapy with immune checkpoint blockade(ICB) has greatly reduced the risk of recurrence and metastatic spread in early and advanced melanoma. However, not all patients benefit from adjuvant treatment: many patients show disease recurrence despite therapy, while those without recurrence harbor the risk for potentially irreversible adverse events. Biomarkers to select patients benefitting most from adjuvant therapy are currently lacking. As body composition assessment using CT images has shown promising results as a prognostic biomarker in stage IV melanoma, we aim to study the applicability of body composition parameters also in adjuvant melanoma treatment.

Methods
We analyze body composition features via CT scans in a retrospective cohort of 109 patients with resected stage IIB-IV melanoma receiving an adjuvant first-line treatment with ICB in our department. In this analysis, we focus on the impact of body composition, especially the presence of low skeletal muscle mass (LSMM), on patients’ survival and occurrence of adverse events (AEs).

Results
In uni- and multivariate analyses, we identify an association between CT-measured LSMM and melanoma-specific survival in patients treated with adjuvant ICB. Furthermore, LSMM is associated with a lower risk for therapy-related AEs, especially hypothyroidism, fatigue, and xerostomia. Conventional serological biomarkers e.g. S100 and LDH and measures of adipose tissue compartments did not show a correlation with survival or the occurrence of AEs.

Conclusions
LSMM constitutes a novel biomarker for melanoma-specific survival in patients treated with adjuvant ICB.
Bumble bee diet breadth increases with local abundance and phenophase duration, not intraspecific variation in body size
Authors: Glenny Will R. , Runyon Justin B. , Burkle Laura A. 
Published: May 2024

AbstractPatterns of abundance across space and time, and intraspecific variation in body size, are two species attributes known to influence diet breadth and the structure of interaction networks. Yet, the relative influence of these attributes on diet breadth is often assumed to be equal among taxonomic groups, and the relationship between intraspecific variation in body size on interaction patterns is frequently neglected. We observed bee–flower interactions in multiple locations across Montana, USA, for two growing seasons and measured spatial and temporal patterns of abundance, along with interspecific and intraspecific variation in body size for prevalent species. We predicted that the association between spatial and temporal patterns of abundance and intraspecific variation in body size, and diet breadth, would be stronger for bumble bee compared to non-bumble bee species, because species with flexible diets and long activity periods can interact with more food items. Bumble bees had higher local abundance, occurred in many local communities, more intraspecific variation in body size, and longer phenophases compared to non-bumble bee species, but only local abundance and phenophase duration had a stronger positive association with the diet breadth of bumble bee compared to non-bumble bee species. Communities with a higher proportion of bumble bees also had higher intraspecific variation in body size at the network-level, and network-level intraspecific variation in body size was positively correlated with diet generalization. Our findings highlight that the association between species attributes and diet breadth changes depending on the taxonomic group, with implications for the structure of interaction networks.
Master–slave elimination scheme for arbitrary smooth nonlinear multi-point constraints
Authors: Boungard Jonas , Wackerfuß Jens 
Published: May 2024

AbstractNonlinear multi-point constraints are essential in modeling various engineering problems, for example in the context of (a) linking individual degrees of freedom of multiple nodes to model nonlinear joints, (b) coupling different element types in finite element analysis, (c) enforcing various types of rigidity in parts of the mesh and (d) considering deformation-dependent Dirichlet boundary conditions. One method for addressing constraints is the master–slave elimination, which offers the benefit of reducing the problem dimension as opposed to Lagrange multipliers and the penalty method. However, the existing master–slave elimination method is limited to linear constraints. In this paper, we introduce a new master–slave elimination method for handling arbitrary smooth nonlinear multi-point constraints in the system of equations of the discretized system. We present a rigorous mathematical derivation of the method. Within this method, new constraints can be easily considered as an item of a “constraint library”; i.e. no case-by-case-programming is required. In addition to the theoretical aspects, we also provide helpful remarks on the efficient implementation. Among others, we show that the new method results in a reduced computational complexity compared to the existing methods. The study also places emphasis on comparing the new approach with existing methods via numerical examples. We have developed innovative benchmarks which encompass all relevant computational properties, and provide analytical and reference solutions. Our findings demonstrate that our new method is as accurate, robust and flexible as the Lagrange multipliers, and more efficient due to the reduction of the total number of degrees of freedom, which is particularly advantageous when a large number of constraints have to be considered.
Accelerating aeroelastic UVLM simulations by inexact Newton algorithms
Authors: Schubert Jenny , Steinbach Marc C. , Hente Christian , Märtins David , Schuster Daniel 
Published: May 2024

AbstractWe consider the aeroelastic simulation of flexible mechanical structures submerged in subsonic fluid flows at low Mach numbers. The nonlinear kinematics of flexible bodies are described in the total Lagrangian formulation and discretized by finite elements. The aerodynamic loads are computed using the unsteady vortex-lattice method wherein a free wake is tracked over time. Each implicit time step in the dynamic simulation then requires solving a nonlinear equation system in the structural variables with additional aerodynamic load terms. Our focus here is on the efficient numerical solution of this system by accelerating the Newton algorithm. The particular structure of the aeroelastic nonlinear system suggests the structural derivative as an approximation to the full derivative in the linear Newton system. We investigate and compare two promising algorithms based on this approximation, a quasi-Newton type algorithm and a novel inexact Newton algorithm. Numerical experiments are performed on a flexible plate and on a wind turbine. Our computational results show that the approximation can indeed accelerate the Newton algorithm substantially. Surprisingly, the theoretically preferable inexact Newton algorithm is much slower than the quasi-Newton algorithm, which motivates further research to speed up derivative evaluations.
Optimal sizing of a proposed stand-alone hybrid energy system in a remote region of southwest Egypt applying different meta-heuristic algorithms
Authors: Abdelsattar Montaser , Mesalam Abdelgayed , Diab Ahmed A. Zaki , Fawzi Abdelrahman , Hamdan I. 
Published: May 2024

AbstractHybrid energy system (HES) is considered a solution to the energy supply issue, particularly in rural areas to achieve their sustainable development goals. The rise in energy consumption has increased the appeal of renewable resources, because of their potential to supply consumers with competitive, carbon-free electricity. This paper suggests strategies for managing energy and the most recently published optimizers for designing a stand-alone HES positioned in a remote region of southwest Egypt. This HES includes two green energy sources (wind and solar) and a storage system for energy (battery) as the first backup in addition to a second backup (diesel). The most recent sizing techniques employing the Chernobyl disaster optimizer, dynamic control cuckoo search (DCCS), and gold rush optimizer have been suggested to obtain the optimal design of the utilized HES. Furthermore, an in-depth evaluation of the applied optimization approaches has been achieved based on a comparative study. A detailed analysis of the studied algorithms aims to identify the optimum algorithm that provides the lowest possible cost at the highest level of reliability for the proposed HES. The simulation results verified that, the DCCS algorithm outperformed other algorithms, indicating its potential for achieving promising solutions.
Comparative analysis of spatial transport characteristics of spring cold-front-type sandstorms in the Hexi Corridor
Authors: Zhang Chunyan , Li Yanying , Wu Wen , Ma Xingwei , Nie Xin 
Published: May 2024

AbstractIn this study, we investigate the spatial transport characteristics of cold-front-type sandstorms with different intensities in the Hexi Corridor based on the hourly observation data from 13 ground-based meteorological stations in the Hexi Corridor, the data in the upper and lower layers from the Meteorological Information Comprehensive Analysis And Process System, and the three-dimensional aerosol observation data of the Vertical Feature Mask product obtained from the Cloud-Aerosol Lidar with Orthogonal Polarization of the United States. The results show that the influence range and horizontal transport distance of cold-front-type sandstorms in the Hexi Corridor are determined by the intensity, thickness and width of the upper-level troughs and the intensity of cold fronts. Generally, cold fronts pass through the Hexi Corridor from noon to evening and stay in this region for a long time or move slowly, which is favorable to the horizontal long-distance transport of sandstorms. The intensity of the 200 hPa upper-level jets is directly proportional to both the influence range and transport distance of sandstorms which primarily occur on the left side of the exit area of an upper-level jet. The strengthening of upper-level jets induces the formation of the vertical circulation cell at middle and low levels. The ascending branch of the circulation cell lifts sand-dust particles from the surface to the upper layers, and the descending branch transports upper-level momentum to the near-surface. This circulation situation increases the near-surface wind speed and forms sandstorms. The occurrence time and descending branch of the secondary circulation cell caused by upper-level jets are important indicators for predicting the occurrence time and falling area of sandstorms. Dust aerosols are mainly concentrated at a height of 2–6 km,.,and they can reach the height of 12 km. When the dust is concentrated at the height of 2–8 km, and the wind speed of 500 hPa and 300 hPa reaches 28 and 32 m s− 1 or above respectively, the cold front sandstorm can realize the long distance transport of thousands of kilometers.