bluuebunny/crossref_metadata_2025_split huggingface dataset:
Exploring Disrupted Gene Networks in Human 22q11.2 Microdeletion
Authors: De Oliveira Alves Camila Cristina , Wolf Ivan Rodrigo , Gamba Bruno Faulin , Bicudo Lucilene Arilho Ribeiro , Valente Guilherme Targino 
Published: May 2024

Several deletions are observed at the 22q11 locus and are responsible for 22q11.2 deletion syndrome (22q11DS), also known as DiGeorge syndrome, conotruncal anomaly face syndrome, or velocardiofacial syndrome. These microdeletions on human chromosome 22 range from 0.7 to 3 Mb. Many genes are affected by 22q11.2 deletion. However, despite the well-established clinical signs for the diagnosis of 22q11.2 deletion syndrome, the interactome background of 22q11.2 deletion syndrome is unknown. Here, we analyzed protein–protein interaction networks (PPIs) to assess the influences of 3 Mb 22q11.2 deletion on this network. We compared the general human PPI network against a network without 48 genes of the 3 Mb 22q11.2 locus in a homozygous condition: we compared topological metrics, enrichment of gene ontology terms, community assignments, and edge rewiring. The PPI networks revealed that this deletion affected the relevance of hundreds of non-deleted genes. Additionally, this 22q11.2 deletion induces intense rewiring of subnetworks, promoting an accumulation of proteins associated with DiGeorge clinical signs (CTCF, YY1, TFAP2A, PPARG, PAX6, RAX, and E2F3) in a single community (community 1). Therefore, we identified new genes that may be associated with the 22q11.2 deletion syndrome. Altogether, the systemic approaches used here yielded new insights into the 22q11.2 deletion syndrome.

Received: 21 February 2024 | Revised: 26 April 2024 | Accepted: 29 April 2024

Conflicts of Interest
The authors declare that they have no conflicts of interest to this work.

Data Availability Statement
The data that support the findings of this study are openly available in HuRI at http://www.interactome-atlas.org/, reference number [26]. The data that support the findings of this study are openly available in HumanNet at https://staging2.inetbio.org/humannetv3/, reference number [27]. The data that support the findings of this study are openly available in ComPPi at https://comppi.linkgroup.hu/, reference number [28]. The data that support the findings of this study are openly available in Biogrid at https://thebiogrid.org/, reference number [29].
Lipoprotein(a) and its impact on cardiovascular disease – the Polish perspective: design and first results of the Zabrze-Lipoprotein(a) Registry
Authors: Dyrbuś Krzysztof , Mędrala Zofia , Konsek Karolina , Nowowiejska-Wiewióra Alicja , Trzeciak Przemysław , Skrzypek Michał , Cieśla Daniel , Banach Maciej , Gąsior Mariusz 
Published: May 2024

IntroductionLipoprotein(a) [Lp(a)] is an independent risk factor for atherosclerotic cardiovascular disease (ASCVD). Increased Lp(a) concentration > 30 mg/dl (75 nmol/l) and especially >50 mg/dl (125 nmol/l) may cause faster atherosclerosis, being an important and underdiagnosed residual cardiovascular risk factor. Thus, there is a need to characterize further the clinical phenotypes in patients at risk for ASCVD with high Lp(a) levels now and during follow-up, while also looking for the possible impact of geographical differences.Material and methodsThe Zabrze Lipoprotein(a) Registry (Zabrze-Lip(a)R) was founded on the basis of data from 2,001 consecutive patients with very high cardiovascular risk treated in a tertiary hospital. The registry patients will be followed for at least 5 years with the possibility of extending this period as an open label study. All-cause and cause-specific mortality, hospitalizations, and cardiovascular events, such as myocardial infarction (MI) and stroke, will be assessed.ResultsThe mean age of patients was 66.4 years (females 37.1%). The median Lp(a) concentration in the entire population was 6.6 mg/dl (16.5 nmol/l) (mean: 14.3 ±19.4 mg/dl). 540 (27%) patients had elevated Lp(a) levels above 30 mg/dl (75 nmol/l); they were significantly older (68.8 vs. 66.3 years; p = 0.04), had significantly lower hemoglobin and hematocrit, and higher platelet count and levels of NT-proBNP and C-reactive protein. The prevalence of elevated Lp(a) > 30 mg/dl (75 nmol/l) concentrations was very high in patients with a chronic coronary syndrome (CCS) (52.2% (282/540) vs. 41.5% (607/1461); p < 0.001), in patients undergoing PCI during hospitalization (23.9 vs. 19%; p = 0.01), and in patients with previous MI (20.6% vs. 14.9%; p = 0.0022). In the multivariable analysis, the independent predictors of elevated Lp(a) > 30 mg/dl (75 nmol/l) were only lower Hb values (OR = 0.925; 95% CI: 0.874–0.978; p = 0.006) and higher platelet count (1.002; 95%CI: 1.000–1.003; p < 0.02).ConclusionsIn Poland, the largest representative of Central and Eastern European countries, 27% of patients at very high cardiovascular risk with established ASCVD experience additional risk related to an elevated Lp(a) level, with every second patient having CCS. Interestingly, only two factors were significantly related to elevated Lp(a) levels: lower Hb values and higher platelet count. However, the clinical relevance of these results needs confirmation.
TINJAUAN HUKUM EKONOMI SYARIAH TERHADAP JUAL BELI MAKANAN DENGAN SISTEM ALL YOU CAN EAT
Authors: Oktapianih Nurul , Makfud Ali , Afandi Setiya 
Published: May 2024

Penelitian ini menjelaskan sistem jual beli makanan all you can eat dalam perspektif hukum ekonomi syariah. All You Can Eat merupakan salah satu strategi pemasaran atau usaha yang diterapkan dalam restoran, terutama pada Restoran Jepang atau Korea. Jenis penelitian ini adalah penelitian kualitatif lapangan (Field Research) dengan menggunakan pendekatan deskriptif analisis. Penulis mendapatkan sumber data primer dari kegiatan observasi, wawancara, dan dokumentasi di kintan buffet. Untuk menguatkan hasil data penulis merujuk pada data-data sekunder berupa buku, jurnal, dll. Penelitian ini menemukan bahwa pelaksanaan jual beli dengan sistem All You Can Eat di Kintan Buffet Puri Indah Mall Jakarta barat yaitu dilakukan dengan mekanisme ketika pengunjung datang ke restoran, pegawai Kintan Buffet pada bagian kasir akan menyambut pengunjung. Apabila pengunjung belum pernah datang maka pegawai restoran akan memberikan informasi mengenai syarat dan ketentuan di Kintan Buffet. Termasuk informasi adanya denda bagi pengunjung yang tidak menghabiskan makanannya melebihi batas waktu yang diberikan (90 menit). Setiap pengunjung dikenakan biaya sebesar Rp 200.000 – Rp 500.000 per orang sesuai menu yang ingin dimakan. Setelah memilih menu, pengunjung diberikan waktu selama 90 menit untuk makan semua yg ada di buffet dari makanan pembuka sampai makanan penutup. Penelitian ini memberikan kesimpulan bahwa meski mengandung gharar pelaksanaan sistem jual beli All You Can Eat di Kintan Buffet diperbolehkan, karena kadar gharar nya terkategorikan ringan. Namun pada sisi akad penerapan denda hal ini tidak diperbolehkan syariat karena diberlakukan setelah akad jual beli berakhir dan membebani pengunjung dengan harga atas suatu barang (makanan) yang menjadi miliknya sendiri.
IMPLEMENTASI MANAJEMEN KEUANGAN SYARIAH SEBAGAI SALAH SATU UPAYA PENGEMBANGAN DAN PENINGKATAN UMKM DI INDONESIA
Authors: Faujiah Ani , Alfayed M. Valke 
Published: May 2024

Tulisan ini bertujuan mengupas salah satu masalah yang dihadapi usaha kecil dan menengah yaitu banyak yang tidak mengerti bagaimana mengelola keuangan dan aset mereka. Akibatnya, banyak usaha kecil menengah Indonesia yang bangkrut. Tulisan ini menggunakan pendekatan kualitatif kepustakaan. Data diperoleh dari buku, jurnal ilmiah dan lainnya yang memiliki relevansi dengan pembahasan yang ada. Tulisan ini memberikan kesimpulan bahwa usaha kecil dan menengah merupakan salah satu pilar perekonomian Indonesia yang perlu memahami manajemen keuangan syariah. Dalam hal pencatatan keuangan, pelaku UMKM perlu memperhatikan beberapa aspek, yakni: mencatat semua arus keuangan yang masuk maupun keluar, mengenali komponen biaya yang dikeluarkan, memiliki buku catatan keuntungan yang diperoleh, dan buku catatan persediaan barang. Untuk membantu pelaku UMKM dalam hal manajemen keuangan telah banyak aplikasi digital yang tersedia dan dapat diunduh gratis.
Field Evaluation of Zero Inertia and Kinematic Wave Models under Furrow Irrigated Bed System in Vertisols
Authors: K.M. Gautam  , Virendra Kumar  , R.C. Purohit  
Published: May 2024

In this field study zero inertia and kinematic wave models have been applied to predict advance and recession times under furrow irrigated bed system. SRFR Version 4.06 software of surface irrigation has been used to obtain the numerical solution of Saint-Venant equation. The predicted advance and recession times were compared with the observed ones. Slope of best fit line, coefficient of determination and standard error indices were calculated and used to evaluate the performance of the models. Zero inertia and Kinematic wave model under estimated (ℷ < 1) the advance and recession time in furrow irrigated bed system. The Zero inertia model predicted comparatively more reliable result in predicting advance and recession time for the field conditions encountered in the study. Both the models, zero inertia and kinematic wave, however predicted advance and recession times slightly more accurately in stream size 2 Ips than 1 Ips per furrow.
5. NGHIÊN CỨU ĐẶC ĐIỂM LÂM SÀNG, CẬN LÂM SÀNG VÀ ĐÁNH GIÁ KẾT QUẢ SỚM ĐIỀU TRỊ UNG THƯ BÀNG QUANG THỂ CHƯA XÂM LẤN CƠ TẠI CẦN THƠ GIAI ĐOẠN 2021-2023
Authors: Phúc Bùi Hoàng , Anh Trần Hoàng , Cảnh Nguyễn Tuấn , Phong Trần Đỗ Thanh 
Published: May 2024

Mục tiêu: (1) Khảo sát đặc điểm lâm sàng, cận lâm sàng ung thư bàng quang thể chưa xâm lấn cơ tại bệnh viện Đa khoa Trung ương Cần Thơ năm 2021-2023; (2) Đánh giá kết quả sớm điều trị ung thư bàng quang thể chưa xâm lấn cơ tại Bệnh viện Đa khoa Trung ương Cần Thơ năm 2021-2023.
Đối tượng và phương pháp nghiên cứu: Hồi cứu mô tả, kết hợp tiến cứu trên 45 bệnh nhân từ 16 tuổi trở lên mắc ung thư bàng quang thể chưa xấm lấn cơ được điều trị tại Bệnh viện Đa khoa Trung ương Cần Thơ từ 01/2021 đến 12/2023.
Kết quả: Nam giới chiếm tỷ lệ cao 88,89%. Nhóm tuổi chiếm tỉ lệ cao nhất là nhóm từ 61 – 80 tuối chiếm tỉ lệ 62,22%. Triệu chứng thiếu máu nhẹ chiếm tỷ lệ 20%. Có 97,78% trường hợp siêu âm phát hiện được u qua siêu âm. Kích thước u trên siêu âm và CT-Scan ổ bụng tương đồng 81,82%. Khối u bàng quang ở giai đoạn Ta chiếm 55,56%, độ biệt hoá G1 chiếm 62,22%. Tác dụng phụ tiểu rát, tiểu buốt chiếm 13,33% và tác dụng phụ đau tức vùng hạ vị chiếm tỉ lệ thấp 2,22% sau khi điều trị bổ trợ bằng Doxorubicin. Kết quả phẫu thuật: hầu hết cho kết quả tốt 95,56%, không có trường hợp đạt kết quả xấu.
Kết luận: Phẫu thuật nội soi cắt đốt u bàng quang thể chưa xâm lấn cơ qua đường niệu đạo là phương pháp an toàn và nên áp dụng rộng rãi tại Cần Thơ.
ІНФУЗІЙНА ФАРМАКОТЕРАПІЯ ДЛЯ КОРЕКЦІЇ АКТИВНОСТІ АМІНОТРАНСФЕРАЗ У ПЛАЗМІ КРОВІ СЕРЕД ОНКОЛОГІЧНИХ ХВОРИХ ПІСЛЯ ПЕРЕДНЬОЇ РЕЗЕКЦІЇ ПРЯМОЇ КИШКИ У РАННЬОМУ ПІСЛЯОПЕРАЦІЙНОМУ ПЕРІОДІ
Authors: Дзісь Богдан , Варивода Євген , Регеда Михайло , Гайдучок Ігор , Гуменюк Ольга , Циснецька Аліна , Варивода Василь , Стасишин Олександра , Тарасюк Олександра , Новак Василь , Дзісь Роман , Чабан Володимир 
Published: May 2024

В сучасних умовах ВООЗ об’єднала зусилля у боротьбі з глобальним тягарем раку. Необхідно підвищення обізнаності в системі правовідносин «лікар-пацієнт-фармацевт». Підтримуюча фармакотерапія важлива для пацієнтів з колоректальним раком. Для виявлення лікувальної дії інфузійного препарату Сорбілакт в оперованих хворих на рак прямої кишки для корекції активності амінотрансфераз у плазмі крові обстежено дві групи онкологічних хворих (основна і контрольна). Основній групі онкологічних хворих після передньої резекції прямої кишки у ранньому післяопераційному періоді внутрішньовенно вводили інфузійний препарат Сорбілакт у дозі 600,0 мл на добу з швидкістю 30 крапель за хвилину протягом 5-ти днів. Контрольній групі - інфузійну терапію здійснювали 5% розчином глюкози у дозі 800,0 мл. Виявлено зростання активності аланін-амінотрансферази і аспартат-амінотрансферази у плазмі крові. при фармакотерапії препаратом Сорбілакт. Інфузійний препарат Сорбілакт рекомендується до широкого медичного застосування в онкологічних хворих після передньої резекції прямої кишки для попередження післяопераційних ускладнень, особливо у ранньому післяопераційному періоді.
Libyan community pharmacists' knowledge, attitude, and practice concerning non-prescription dispensing of antibiotics
Authors: Shaibani Rehab , Alaswad Randa , Alarbe Nora , Rihee Malak 
Published: May 2024

Antibiotics are prescription only medications, but their dispensing as over the counter drugs constitutes one of the main causes of antibiotic resistance. Antibiotic resistance threatens the life of people around the world, as indicated by world and Health Organization. Therefore, a global effort and collaboration are required to decrease and control the development and spread of antibiotic resistance. The purpose of this study is to evaluate the knowledge, attitude, and practice of community pharmacists regarding dispensing of antibiotics without prescription (DAWP) in Libya. Self- administered questionnaire has been created with a cross sectional design and statistical package for social sciences(SPSS) version 27.0 was used for descriptive statistics analysis. The vast majority of respondents were female (82.2%) and (79.4%) of respondents were less than 30 years old. About 43% of community pharmacists reported that they dispense antibiotics without prescription. Feeling competent to dispense antibiotics as over the counter drug was the most common reason for antibiotic dispensing without prescription. Amoxicillin, Azithromycin and Metronidazole were the most commonly dispensed antibiotics without a prescription respectively. In summary, dispensing antibiotics without a prescription is widespread in Libya, especiallyWhen patient asks for a particular antibiotic.
TEXTILES IN RESIDENTIAL INTERIORS AS A DESIGN PROBLEM
Authors: Барсукова Н.И. 
Published: May 2024

В статье раскрывается проблематика текстиля в жилом интерьере с позиции декоративного искусства и дизайна, его функционального и художественного значения, представлена специфика применения его как декоративного искусства и средства дизайна в связи с климатическими условиями, общей стилистикой интерьера; показаны различные возможности его применения. Актуальность и новизна данной статьи обосновывается необходимостью введения курса «Текстиль в интерьере» в образовательные вузовские программы по направлениям подготовки «Дизайн интерьера» и «Дизайн среды»
The article reveals the problems of textiles in a residential interior from the perspective of decorative art and design, its functional and artistic significance, presents the specifics of its application as a decorative art and design tool in connection with climatic conditions and the general style of the interior, shows the various possibilities of its application. The relevance and novelty of this article is justified by the need to introduce the “Textiles in Interior” course into educational university programs in the “Interior Design” and “Environment Design” areas of training.
FREE PAINTING ON FABRIC AND EMBROIDERY IN EARLY ARTWORK OF ZOYA LENDENSKAYA-BOLSHAKOVA
Authors: Ермолаева М.И. 
Published: May 2024

Санкт-Петербургский художник по текстилю Зоя ЛенденскаяБольшакова с единомышленниками-выпускниками кафедры художественного текстиля Санкт-Петербургской государственной художественно-промышленной академии имени А. Л. Штиглица (бывшее ЛВХПУ им. В. И. Мухиной) основала успешное творческое объединение, известное сегодня как Гильдия Текстильщиков Санкт-Петербурга. Зоя Ленденская-Большакова — плодовитый художник-экспериментатор, она мастерски использует в своем творчестве традиционные текстильные техники, тонко передавая с помощью них свой внутренний мир.
St. Petersburg textile artist Zoya Lendenskaya-Bolshakova with like-minded people – graduates of the Department of Artistic Textiles of the St. Petersburg Stieglitz State Academy of Arts and Design (formerly Leningrad V. Mukhina Higher School of Art and Industry) founded a successful creative association, known today as the St. Petersburg Guild of Artists on Textiles. Zoya LendenskayaBolshakova is a prolific experimental artist; she skillfully uses traditional textile techniques in her work, subtly conveying her inner world.
THE MEANING AND SYMBOLISM OF THE JAPANESE HACHIMAKI – A CLOTH HEADBAND
Authors: Журавская Т.М. 
Published: May 2024

В традиционной японской одежде используется хатимаки — головная повязка из куска ткани, завязывающаяся определенным образом. Ее история восходит к эпохе Хэйан (794–1185). В наше время такие повязки также используют с определенной целью: во время праздничных уличных шествий, спортивных соревнований, при выступлении современных музыкальных групп и т. д.
Traditional Japanese clothing includes hachimaki – a headband made of a piece of cloth, tied in a certain way. Its history dates back to the Heian era (794– 1185). Nowadays, such headbands are also used for a specific purpose: during festive street processions, sports competitions, when performing modern musical groups, etc.
TAPESTRIES IN ITALY DURING THE RENAISSANCE
Authors: Пичугина О.К. 
Published: May 2024

Статья посвящена истории развития шпалерного ткачества и бытования шпалер на территории Италии в XV–XVI вв. Рассматривается возникновение центров шпалерного производства в Венеции, Мантуе, Ферраре, Флоренции и Риме. Выявляется определяющая роль бургундских и нидерландских ткачей в создании шпалерных мастерских под патронажем итальянской аристократии и включение в ковровое производство выдающихся итальянских художников от Мантеньи и Козимо Тура до Рафаэля, Сальвиати, Понтормо и Бронзино.
The article is devoted to the history of the development of trellis weaving and the use of trellises in Italy in the 15th–16th centuries. The article considers the emergence of trellis production centers in Venice, Mantua, Ferrara, Florence and Rome. The determining role of Burgundian and Dutch weavers in the creation of trellis workshops and under the patronage of Italian lords and the inclusion of outstanding Italian artists from Mantegna and Cosimo Tura to Raphael, Salviati, Pontormo and Bronzino in carpet production is revealed.
THEATRICALITY IN THE ART OF TEXTILES OF THE 20th–21st CENTURIES
Authors: Цветкова Н.Н. 
Published: May 2024

Во второй половине ХХ столетия в период «пластического взрыва» появились новые объемно-пространственные текстильные формы — артобъекты, инсталляции, перформансы и хэппенинги. Многие из созданных в это время работ отличаются своеобразной «театральностью». В современном текстильном искусстве тенденция соединения ткани с театральным действом остается актуальной. В статье рассмотрены примеры взаимовлияния и взаимодействия текстильных форм с пространством театра.
In the second half of the twentieth century, during the period of the “plastic explosion”, new three-dimensional textile forms appeared – art objects, installations, performances and happenings. Many of the works created at this time are distinguished by a kind of “theatricality”. In modern textile art, the tendency to combine fabric with theatrical action remains relevant. The article considers examples of the mutual influence and interaction of textile forms with the theater space.
THE “UNQUENCHABLE” SYMBOL OF CULTURE. THE IMAGE OF LIGHT IN A TAPESTRY ON THE EXAMPLE OF THE WORKS BY ALEXANDER GORAZDIN
Authors: Юрченко С.А. , Докучаева Е.Е. , Полякова Е.В. 
Published: May 2024

Свет — один из важнейших архетипов русской культуры. Это отразилось в древних символах, орнаментах, иконописи, церковных фресках, а также в живописи, графике, почти во все исторические эпохи нашей страны. «Световой» философией пронизаны многие работы русских художников различных направлений, но до сих пор данная тема не была рассмотрена в гобелене. Проблема «света» в художественном гобелене будет раскрыта на основе произведений художника, представителя московской школы А. С. Гораздина.
Light is one of the most significant archetypes in Russian culture. It reflected in ancient symbols, ornaments, iconography, church frescoes, as well as in painting and graphics in almost all historical epochs of our country. The “light” philosophy permeates many works by Russian artists of various directions. But so far this topic has not been considered in the tapestry. The problem of “light” in the tapestry will be explored on the example of the works of the Moscow School artist Alexander Gorazdin.
Analysis of Cash Waqfs and Real Wages in Ottoman Rumelia, 1500-1914
Authors: Altay Bora , Bulut Mehmet 
Published: May 2024

Purpose - This study employs a substantial number of primary sources of cash waqf contracts (waqfiyya) to conduct a long-term analysis of cash waqfs and the real wages of waqf employees in Ottoman Rumelia from the sixteenth century to the First World War.
Design/Methodology/Approach - The descriptive analysis includes economic variables recorded in contracts. The analysis focuses on the trend of capital levels, profit shares (riba), and numbers of cash waqfs over 50-year periods, and the daily wages of the five different groups.
Originality/Value - This study’s main contribution is the quantitative and systematic analysis of capital levels and real wages, for the first time.
Research Implications - The findings indicate that daily wages increased and peaked during the seventeenth and eighteenth centuries, which may reflect economic growth. However, real wages decreased in the early twentieth century, likely because of the exogenous shocks of wars, revolts, and revolutionary movements in the Balkan territories.
Keywords - Economic History, Islamic Finance, The Ottoman Empire, Cash Waqf, Rumelia, Real Wages
Article Classification – Research paper
Determinação eletroanalítica de dopamina em amostras de urina sintética e amostras de água do Rio Itapecuru
Authors: Andrade Ana Paula dos Santos , Oliveira Carlos Eduardo Lima de , Oliveira Gláucia Corrêa de , Santos Jakeline Costa Santos , Castilho Quésia Guedes da Silva , Müller Renata Medeiros Lobo 
Published: May 2024

A dopamina (1,2-dihidroxibenzeno-5-etanoamina) é um importante neurotransmissor, pertencente à família das catecolaminas e é precursor metabólico de outras catecolaminas, como noradrenalina a adrenalina, o presente trabalho tem por objetivo desenvolver um método eletroanalítico para determinação de dopamina (DA) em amostras de urina sintética e em amostras água do rio Itapecurú localizado em Caxias-MA , utilizando um mini eletrodo impresso de carbono (EIC) como sensor através da técnica de voltametria de pulso diferencial (VPD). Com o auxílio de mini-potenciostato/galvanostato acoplado a um computador, foram obtidos resultados para estudo do eletrólito de suporte, da concentração e do pH. Os estudos dos parâmetros das técnicas de voltametria de pulso diferencial foram realizados em meio a tampão fosfato 0,1 mol L-1 e pH 7,0, na presença de DA 1,0x10-4 mol L-1, posteriormente, com condições aprimoradas foi obtida uma curva analítica com comportamento linear no intervalo de concentração de DA entre 1,93 x10-6 a 1,89 x10-5 mol L-1, com limites de detecção e de quantificação de 1,20 x 10-7 e 4,00 x 10-7 mol L-1, respectivamente. Utilizando o método de adição de padrão como abordagem principal na aplicação, obteve-se sucesso na análise de DA em amostras provenientes do rio Itapecuru e de urina sintética, demonstrando que os resultados obtidos foram satisfatórios, comprovando a viabilidade do método eletroquímico proposto para a quantificação de DA em amostras de interesse.