bluuebunny/crossref_metadata_2025_split huggingface dataset:
étude histochimique du derme des diabétiques
Authors: AZERAD E. , DE BRUX J. , GRUPPER R. GODECHOT ET C. 
Published: August 2010

RésuméAvec le contrôle de 7 sujets normaux d'âge différent, nous avons étudié chez 24 diabétiques de 27 à 75 ans dont la maladie date de quelques mois à 19 ans. le comportement histochimique du derme cutané, d'aspect sain, prélevé par »drill biopsy«. Nous avons constaté:A — Des troubles dans le métabolisme des hydrates de carbone, se traduisant:— sur les vaisseaux:par une augmentation généralement très importante du taux des polysaccharides vasculaires et périvasculaires et augmentation du nombre et du volume des cellules de type mastocytaire.— sur le tissu conjonctif dermique:par 4 sortes de lésions:1° un dépôt de glycogène chez un petit nombre de sujets (3 cas);2° une augmentation de la concentration des mucopolysaccharides acides (4 cas);3° une absence de glycogène chez d'autres dont le derme apparaît scléreux (9 cas);4° la présence de substances Hotchkiss positives après incubation dans l'amylase qui, selon toute vraisemblance, sont des graisses non saturées (phospholipides) démasquées par l'hydrolyse puis l'oxydation en aldéhydes des groupes éthyléniques (8 cas).B — Des dépôts lipidiques:Décelés par les méthodes de routine, tantôt localisés dans le derme sous forme de petites gouttelettes de graisses neutres, très rarement acides, tantôt et plus frequemment au niveau de la paroi des vaisseaux dermiques où elles apparaissent d'abord dans la région sous‐endothéliale formant un mince liseré (graisses acides, graisses à radical carbonyl) puis, quoique plus rarement sous forme d'infiltration diffuse des graisses neutres de toute la paroi, mais la plupart de ces graisses sont toujours et partout en très minime quantité.L'augmentation de concentration des hydrates de carbone et des lipides surtout masqués dans le derme des diabétiques, très rarement libres, aboutit dans un certain nombre de cas à l'apparition d'une forme de métamorphisme connue sous le nom de hyaline.Jusqu'à présent, seules les lésions cutanées des diabétiques ont fait l'objet de recherches morphologiques, histologiques et chimiques; elles sont considérées comme étant de constitution essentiellement lipoïdiques et portent le nom de dyslipoïdoses diabétiques. L'étude de la peau normale ou soi‐disant telle du diabétique nous montre en réalité qu'il s'agit de dysmétabolismes étendus non seulement aux graisses, mais également aux hydrates de carbone et selon toute vraisemblance dans les cas extrêmes, aux protéines. Les lésions sont done des dysglucido‐lipidoprotéinoses avec, selon la prédominance de telle substance des dysglucido‐lipidoses, des dyslipido‐protéinoses.Service d'endocrinologie de l'Hôpital Beaujon: Dr E. Azerad.Laboratoire d'Anatomie‐Pathologique de l'Hôpital Boucicaut: Professeur agrégé Jean de Brux.
THE DIAGNOSTIC VALUE OF DETERMINATION OF TUBULAR REABSORPTIVE CAPACITY FOR GLUCOSE IN PARATHYROID DISEASE
Authors: Halver Bent 
Published: August 2010

AbstractPrevious observations of changes of tubular reabsorptive capacity for glucose (TmG/GFR ratio) as a consequence of parathyroid disorder are supported by the results of a follow‐up study of an additional fortyfive patients. A distinct separation by TmG/GFR ratio exists in patients with hyper‐ and hypoparathyroidism. In five of thirty‐three patients with hyperparathyroidism (15%) the values of TmG/GFR ratio were within mean ± 2 S.D. of the values obtained in twenty‐four control patients. Parathyroid extract increases and removal of parathyroid adenoma or suppression of the parathyroid function by i.v. calcium decreases the ratio.The value of a clinical application of this physiologic phenomenon is discussed. The ratio might well point to the actual parathyroid function. An increased ratio, however, does not illustrate whether a hyperparathyroidism is autonomous, secondarily stimulated, or due to secretion of a parathyroid hormone‐like substance. And a decreased ratio does not exclude hyperparathyroidism since three patients with hyperparathyroidism due to water‐clear cell affection showed low values of the ratio. Finally, other factors than parathyroid hormone influence the reabsorptive capacity for glucose.In excluding coexisting hyperparathyroidism in hypercalcemic sarcoidosis, and, probably, in separation of idiopathic hypercalcuria into a renal form with stimulated parathyroid function and an intestinal form with suppressed parathyroid function, determination of the TmG/GFR ratio might be valuable.
A RETROSPECTIVE STUDY OF COMPLICATIONS FOLLOWING NEPHROANGIOGRAPHY, CARDIOANGIOGRAPHY AND CORONARY ANGIOGRAPHY
Authors: Södermark Tore , Mindus Per 
Published: August 2010

Abstract A study is presented of 329 records of patients on whom angiography had been performed.Fifteen complications were found (4.6%). These are listed in Table IVThe five complications occurring in connection with nephroangiographies performed in the investigation of hypertension are assessed against the benefit obtained. Only three patients out of 101 investigated have derived any benefit from the resulting operation.Some of the literature is reviewed and the authors conclude that the indications for nephroangiography in the investigation of hypertension might be modified by the inclusion of other selective investigations.
SERUM IMMUNOGLOBULINS AND ORGAN‐SPECIFIC, CELLULAR HYPERSENSITIVITY IN ULCERATIVE COLITIS AND CROHN'S DISEASE
Authors: Weeke B. , Bendixen G. 
Published: August 2010

Abstract The serum concentrations of IgG, IgA, and IgM have been measured in 22 patients with ulcerative colitis and in 23 patients with Crohn's disease. The concentration of IgG was significantly higher in ulcerative colitis than in Crohn's disease, but the examination did not show any major differences between the two conditions or alterations from the normal. In Crohn's disease the serum concentration of IgG was lower in patients treated than in patients not treated with glucocorticoids. A similar difference was not found in ulcerative colitis.In a parallel study on the same patients the in vitro inhibition of leucocyte migration induced by jejunoileal and colonic mucosa components was examined. A reactivity, which is probably an in vitro correlate to organ‐specific, cellular hypersensitivity to intestinal mucosa components, was demonstrated in a majority of the patients with ulcerative colitis, whereas patients with Crohn's disease did not differ significantly from contro's. There was no correlation between the serum concentration of the various immunoglobulins and the result of the leucocyte migration test.As important fluctuations in production, catabolism, extravascular deposit, and loss of immunoglobulins may be concealed behind comparatively normal serum immunoglobulin concentrations, more conclusive results may be gained from examinations which include metabolic studies of the immunoglobulins.
INCREASED ENTERIC FORMATION OF HISTAMINE IN CHRONIC PANCREATITIS
Authors: Sjaastad Ottar 
Published: August 2010

Abstract Patients with chronic pancreatitis, in contrast to patients with acute pancreatitis, were found to have increased excretion of conjugated histamine in urine (7 of 8 patients). A close correlation existed between the amounts of conjugated histamine in urine and the concentration of histamine‐like activity in the feces. Fecal samples from patients, in contrast to samples from controls, possessed a capacity to form histamine‐like activity from L‐histidine and N‐acetyl‐L‐histidine. Sterile filtrates on the other hand possessed no such ability. Feces from patients had a significantly lower pH than control feces. This may be a predisposing factor for the observed histamine formation, since the bacterial L‐histidine dicarboxylase has a low pH optimum.It is concluded that the excess conjugated histamine in urine in these patients originates in the lumen of the gastrointestinal tract.
STUDIES IN URINARY TRACT INFECTIONS
Authors: Mabeck C. E. 
Published: August 2010

Abstract Methods for the determination of leucocyte excretion in the urine have been studied, and an investigation has been made of the relationship between pyuria and bacteriuria.All of 42 women with no evidence of urinary tract disease excreted fewer than 400,000 leucocytes per hour, while 144 out of 152 women with bacteriuria excreted more than 400,000 leucocytes per hour, regardless of the type of bacteria isolated from the urine. Among these patients the excretion rate was found to be higher in those with impaired urine concentration ability, i.e. with signs of pyelonephritis.Pyuria can be diagnosed by estimation of the leucocyte excretion rate or by determination of the leucocyte concentration in the urine. There were more than 10 leucocytes per mm3 of urine in 97% of the specimens from 164 patients who excreted more than 400,000 leucocytes per hour. Ten or fewer leucocytes per mm3 were found in the urine from 92% of the 71 subjects who had excretion rates below 400,000 leucocytes per hour. With the technique employed for microscopic examination of the urinary sediment, the finding of three or more leucocytes per high‐power field indicates pyuria; if there are fewer than three, pyuria cannot, however, be ruled out.
IMMUNOGLOBULINS IN SERUM AND JEJUNAL BIOPSIES IN NON‐TROPICAL SPRUE
Authors: Søltoft J. , Weeke B. 
Published: August 2010

Abstract A study has been made of 12 patients with non‐tropical sprue. Immunochemical determinations of serum IgG, IgA and IgM were carried out prior to gluten‐free diet (9 patients) and during treatment (10 patients). Immunofluorescent microscopy of jejunal biopsies from the same patients was performed prior to (10 cases) and during treatment (6 cases). Fluorescent antisera specifically reacting with IgG, IgA and IgM were applied and the cells containing these immunoglobulins were differentiated and quantitated accordingly.Serum IgM, which was decreased in untreated patients, was normalized during treatment. Serum levels of IgG and IgA were normal. In both treated and untreated cases of sprue increased numbers of cells containing IgG and IgM were found. The immunoglobulin levels of serum were not correlated to the area of cells containing the corresponding immunoglobulins.
IDIOPATHIC PULMONARY HYPERTENSION IN TWO SIBLINGS
Authors: Robertson Bengt , Rosenhamer Gunnar , Lindberg Jan 
Published: August 2010

Abstract The clinical course and patho‐physiologic features of idiopathic pulmonary hypertension in two female siblings aged 26 and 22 years are reported. The pulmonary vascular lesions were studied in serial histologic sections and a morphometric method was used for the determination of medial hypertrophy in the muscular pulmonary arteries. Microangiographic examination of the pulmonary arterial system was also done in one case. The pulmonary vascular lesions were similar in both cases, with prominent medial hypertrophy in muscular pulmonary arteries, as well as necrotizing arteritis, cellular intimal proliferation with plexiform lesions, and segmental fibrous obliteration. The alveolar capillaries were normal or, in places, dilated, and there was microangiographic and histologic evidence of collateral arterial supply of the alveolar capillary bed peripheral to obliterated segments of the pulmonary artery.This report includes the first microangiographic description of the plexiform lesions, which could be identified as tortuous vascular channels, some of which did not allow the further transmission of contrast medium.
QUANTITATIVE ASPECTS OF LIPOLYSIS AND REESTERIFICATION IN HUMAN ADIPOSE TISSUE IN VITRO
Authors: Björntorp Per , Karlsson Majvor , Hovden Anita 
Published: August 2010

Abstract. The capacity of human adipose tissue specimens, obtained during surgery, to release glycerol and to reesterify free fatty acids was measured in vitro under different experimental conditions.Glycerol release was about 0.5 μmoles/g wet weight/h under basal conditions. As compared with the epididymal fat pad of 250–350 g rats, human subcutaneous adipose tissue showed a maximal lipolytic response to hormones which was only 1/15 in young patients and 1/50 in older patients. Isolated human fat cells were not different from intact tissue. Catecholamines gave higher lipolytic response than the peptide hormones ACTH, glucagon and growth hormone with dexamethasone.Reesterification of free fatty acids as measured by the balance method was low in these fasting patients undergoing surgery. It increased after addition of insulin or large amounts of glucose in vitro, or after glucose infusion into the patient before surgery. Free fat cells showed no difference compared with intact tissue. Omental fat reesterified more fatty acids than subcutaneous adipose tissue.By parallel measurements of reesterification with the balance method and with glyceride synthesis from labelled glucose it was possible to show that, in some cases, the latter method gave higher reesterification than the balance method. This indicates a significant contribution of fatty acids from partial hydrolysis in the lipolytic process.These results show that triglycerides in human subcutaneous adipose tissue have a much slower turnover than in the rat epididymal fat pad. This is more pronounced at a more advanced age, which may contribute to the greater tendency to obesity with increasing age. The results furthermore suggest that, in these specimens taken from operated patients after 18 hours fasting, in spite of the low lipolytic potential, reesterification of free fatty acids is so low that it cannot match lipolysis and fatty acid outflow increases. An alternative explanation is partial hydrolysis of triglycerides.
CARDIOVASCULAR STUDY OF 100 CHRONIC ALCOHOLICS
Authors: Härtel Gottfried , Louhija Antti , Konttinen Aarne 
Published: August 2010

Abstract. Clinical, ECG, X‐ray and laboratory findings are reported in a series of 100 male chronic alcoholics aged from 23 to 63 years and hospitalized for psychiatric and social reasons. Eighty per cent of the patients were periodic drinkers, and in 80 per cent alcoholism had lasted for more than 10 years.Although palpitation, extrasystoles, dyspnea and chest pain were usual complaints, no definite cases of alcoholic cardiomyopathy were found. The ECG abnormalities recorded were of about the same order as found in other groups of Finnish men of the same age except for sinus tachycardia (21 per cent) and prolongation of the Q‐T time (7 per cent).One third of the patients had chronic cough, 17 had signs of old tuberculous lung disease, 52 had enlargement and/or tenderness of the liver. Anemia and hypomagnesemia were recorded in 55 and 42 per cent, respectively.Failure to detect cardiomyopathy in this study is considered to be due to the low incidence of specific heart disease in alcoholics or perhaps to the periodic type of drinking with poor caloric intake during the drinking bouts in most of the patients in the present material.
THE ELECTROCARDIOGRAPHIC DIAGNOSIS OF LEFT VENTRICULAR HYPERTROPHY
Authors: Skjæggestad Ö. , Kierulf P. 
Published: August 2010

Abstract. In a patho‐anatomical study the accuracy of the usual ECG criteria of LVH has been tested in 95 patients above 50 years. Bundle branch block, myocardial infarction and isolated right ventricular hypertrophy were excluded. According to the heart weight and the thickness of the free left ventricular wall the material was divided into a group with pronounced left ventricular hypertrophy (LVH) and a control group showing no evidence of LVH. The anatomically uncertain cases were gathered in an additional group.Sv1 + Rv5‐6 > 35 mm and Smax + Rmax, V1–6 > 40 mm were the most sensitive voltage criteria (70‐45% in the LVH group), the frequency of positives in the control group being 11%.In diagnosing LVH the onset of the ventricular activation time (VAT) was superior to the QRS duration. Twenty‐five per cent of the patients with LVH had a ventricular activation time (VAT) ≥ 0.06î, while as many as 80% had VAT ≥ 0.05î. The numbers of positive values in the control group were 0 and 7% respectively.ST depression together with inverted T‐wave in the lateral precordial leads was seen in 65% of the LVH group, and in 4% of the control group.Based on the results of the present study various combinations of criteria for the diagnosis of LVH have been discussed.
INTENSIVE CARE OF MYOCARDIAL INFARCTION
Authors: Linko E. , Koskinen P. J. , Ruosteenoja R. , Kauranen O. , Hakala T. 
Published: August 2010

Abstract. An analysis of 329 cases with acute myocardial infarction (AMI) treated in an intensive care unit for internal medicine (ICU) during a two‐year period is presented. The series comprises 44% of all hospitalized AMI cases within this period. 191 patients were admitted directly via the emergency department, 138 were transferred from medical wards to the ICU. In principle only the most severe cases were admitted to the ICU.The “direct” and “transfer” groups are compared as to: (a) the clinical severity of the disease, (b) delay between onset of symptoms and arrival in hospital, and (c) incidence and prognostic effect of shock, congestive heart failure and arrhythmias.Special attention is directed to cardiac arrest. In the case of primary ventricular fibrillation occurring in the ICU patients the results were very good. In the case of complicating ventricular fibrillation the results were rather good. Half of the 69 patients with ventricular fibrillation left the hospital alive. In contrast, the results of resuscitation in asystole were very poor.The results obtained very much support the opinion that the AMI patients need special surveillance and possibilities for qualified intensive measures during their stay in hospital, especially in the early phase of their disease.
STUDIES IN SUBJECTS WITH POSITIVE POSTPRANDIAL CLINISTIXr̀ TEST
Authors: Lundquist Ingmar , Nordén Åke , Scherstén Bengt 
Published: August 2010

Abstract. In a diabetes detection survey based on postprandial Clinistixr̀ testing, 2477 out of 228,833 participants (1.08%) reacted positively. In 2180 a 3‐hour oral glucose tolerance test was performed. Diagnostic criteria for diabetes were established in a random sample from the same population matched in age and sex. The controls were healthy and had no known heredity for diabetes. The requirement for a diagnosis of diabetes was that all 10 capillary blood sugar values during the tolerance test should exceed the corresponding mean plus 3 S.D. for the control group. Likewise a normal tolerance was only considered present when none of the 10 values reached the mean plus 2 S.D. for the control group.A diagnosis of diabetes was made in 538 subjects, i.e. 0.2% of the population under study.Fasting SILA values in 16 normal men less than 50 years of age showed a mean of 94 μU per ml. and in 12 men more than 50 a mean value of 83 μU per ml was found. Fasting SILA values in eight normal women less than 50 showed a mean of 34 μU per ml, and in nine women more than 50 a mean of 75 μU per ml was found. The low value in women less than 50 was significantly different (p <0.001) from the male group and also from values found in women more than 50 years of age (p<0.01).Fasting SILA in 16 men and 14 women with newly discovered diabetes and age more than 50 showed all values in the normal range. Three diabetic women less than 50 had 50, 61, and 146 μU per ml.SILA during the glucose tolerance test in six patients with diabetes showed a subnormal response in all of them.SILA during the glucose tolerance test in five subjects considered diabetics by conventional criteria, but not according to our criteria, showed a normal response.Fasting serum corticosteroids in six diabetic subjects were significantly higher than in five controls.Serum corticosteroids during the glucose tolerance test dropped to the same base level both in the diabetic and in the normal group.
A SMALL OUTBREAK OF COXSACKIE B5 INFECTION WITH TWO CASES OF CARDIAC INVOLVEMENT AND ORCHITIS FOLLOWED BY TESTICULAR ATROPHY
Authors: Freij L. , Norrby R. , Olsson B. 
Published: August 2010

Abstract. An outbreak of Coxsackie B5 infection in a group of six male students is reported. Four of the patients had the symptoms of an uncomplicated enterovirus infection with fever, chills, muscular pains etc. In two cases there was, however, marked cardiac involvement with severe chest pains and ECG changes. In addition these two patients had orchitis with secondary testicular atrophy.Immunoglobulin separation and demonstration of IgMantibodies against Coxsackie B5 was used for the confirmation of the virological diagnosis in three of the cases. The value of this technique is discussed in the paper.
KIDNEY PRESERVATION WITH HYPOTHERMIA AND HYPERBARIC OXYGEN
Authors: Løkkegaard H. , Fernandes A. , Gyrd‐Hansen N. , Hansen R. Iversen , Hasselager E. , Kemp E. , Lund F. , Rasmussen Folke 
Published: August 2010

Abstract. Preservation of kidneys for 24 hours by means of hypothermia (5°C) and hyperbaric oxygen (50, 25 or 15 ATA) has been studied in experiments on pigs.At none of the oxygen pressures used was survival of the pigs achieved when contralateral nephrectomy was performed in conjunction with transplantation. Use of 50 and 25 ATA oxygen pressure caused greater damage to the tissue than 15 ATA. With postponement of contralateral nephrectomy for three weeks after the transplantation, the function of the kidney stored at 15 ATA oxygen pressure was determined by means of inulin, endogenous creatinine, urea and PAH clearances 10, 31, 52, 73 and 94 days after contralateral nephrectomy. The renal function was reduced in all experiments when compared to a control group of autotransplanted, not long‐term preserved pig kidneys.
SURVIVAL AND MORTALITY IN MALIGNANT (GRADE IV) AND GRADE III HYPERTENSION
Authors: Hood B. , Örndahl G. , Björk S. 
Published: August 2010

Abstract. A series of malignant and other severe hypertensives (grade IV, 128 subjects, grade III, 177 subjects, according to the classification of Keith, Wagener and Barker) were submitted to energetic antihypertensive treatment, starting in October 1950. The patients have been followed from 5 to 17 years. Overall five‐year survival rates were in grade IV 50%, in grade III 61%. These results compare favorably with the results reported by other investigators.Subdividing the material into four consecutive patient groups, as regards the start of treatment, the most striking increase in five‐year survival in comparison with earlier untreated control material was observed already in the first group, starting treatment in the early fifties. The tendency to further improvement was rather slight. However, more advanced age and signs of more severe vascular damage in vital areas in the later patient groups might partly explain this, patients without such unfavorable factors showing a better prognosis in the last two groups.Of the four major causes of death, congestive failure was most markedly suppressed, cerebro‐vascular lesions and uremia clearly lowered, while myocardial infarction remained virtually unaffected.Measures discussed for further improving prognosis were active tracing and energetic treatment of less advanced stages of hypertensive disease, improved detection of impaired renal function, prophylactic measures against pyelonephritis and an aggressive approach to simultaneous control of other “coronary and cerebro‐vascular high risk factors” as defined by prospective studies.