bluuebunny/crossref_metadata_2025_split huggingface dataset:
Using branding to effect internal change at Spie Batignolles
Authors: Collins Hilary , Crespin‐Mazet Florence , Goglio‐Primard Karine 
Published: October 2011

AbstractThis article examines the role of branding as a vector for internal communication and as a method of stimulating learning and change. Instead of focusing on the external impact of the brand, it uses an in‐depth case study in the French construction industry to show how a commercial brand can foster the emergence of internal communities that stimulate information exchange, the sharing of best practices, and innovation. The members of these communities collectively developed their own tools, vocabulary, and management practices around the brand to make it their own—a process that influenced their personal identity as well as the firm's organizational identity. The results of this study suggest that a brand can encourage the transfer of knowledge drawn from localized experience within a firm. © 2011 Wiley Periodicals, Inc.
A clinically applicable six‐segmented foot model
Authors: De Mits Sophie , Segers Veerle , Woodburn Jim , Elewaut Dirk , De Clercq Dirk , Roosen Philip 
Published: October 2011

AbstractWe describe a multi‐segmented foot model comprising lower leg, rearfoot, midfoot, lateral forefoot, medial forefoot, and hallux for routine use in a clinical setting. The Ghent Foot Model describes the kinematic patterns of functional units of the foot, especially the midfoot, to investigate patient populations where midfoot deformation or dysfunction is an important feature, for example, rheumatoid arthritis patients. Data were obtained from surface markers by a 6 camera motion capture system at 500 Hz. Ten healthy subjects walked barefoot along a 12 m walkway at self‐selected speed. Joint angles (rearfoot to shank, midfoot to rearfoot, lateral and medial forefoot to midfoot, and hallux to medial forefoot) in the sagittal, frontal, and transverse plane are reported according to anatomically based reference frames. These angles were calculated and reported during the foot rollover phases in stance, detected by synchronized plantar pressure measurements. Repeated measurements of each subject revealed low intra‐subject variability, varying between 0.7° and 2.3° for the minimum values, between 0.5° and 2.1° for the maximum values, and between 0.8° and 5.8° for the ROM. The described movement patterns were repeatable and consistent with biomechanical and clinical knowledge. As such, the Ghent Foot model permits intersegment, in vivo motion measurement of the foot, which is crucial for both clinical and research applications. © 2011 Orthopaedic Research Society. © 2011 Orthopaedic Research Society Published by Wiley Periodicals, Inc. J Orthop Res 30:655–661, 2012
The effect of aging on migration, proliferation, and collagen expression of tenocytes in response to ciprofloxacin
Authors: Chang Hsiang‐Ning , Pang Jong‐Hwei S. , Chen Carl P.C. , Ko Pei‐Chih , Lin Miao‐Sui , Tsai Wen‐Chung , Yang Yun‐Ming 
Published: October 2011

AbstractQuinolone‐induced tendinopathy or tendon rupture tends to be age‐related. However, the synergistic effects of quinolone and aging on tenocytes remained to be explored. Tenocytes intrinsic to rat Achilles tendon from two age groups (young: 2 months; and near senescent (old): 24 months) were treated with ciprofloxacin. Tenocyte migration and proliferation were assessed by transwell filter migration assay and MTT (3‐[4,5‐Dimethylthiazol‐2‐yl]‐2,5‐diphenyltetrazolium bromide) assay, respectively. Messenger RNA and protein expressions of types I and III collagen were determined by reverse transcription‐polymerase chain reaction (RT/PCR) and Western blot analysis, respectively. Transwell filter migration assay revealed that ciprofloxacin inhibited tenocytes migration, which became more significant in old tenocytes (p < 0.05). The results of MTT assay revealed that tenocytes proliferation decreased after ciprofloxacin treatment (p < 0.05), which also became more significant in old tenocytes. The results of RT‐PCR and Western blot analysis revealed that mRNA and protein expressions of type I collagen remained unchanged in either young or old tenocytes with ciprofloxacin treatment, whereas the expressions of type III collagen were down‐regulated by ciprofloxacin, which was more significant in old tenocytes. In conclusion, aging potentiated the ciprofloxacin‐mediated inhibition of migration, proliferation, and expression of type III collagen of tenocytes. © 2011 Orthopaedic Research Society Published by Wiley Periodicals, Inc. J Orthop Res 30:764–768, 2012
Successful reconstruction of scalp and skull defects: Lessons learned from a large series
Authors: Shonka David C. , Potash Andrea E. , Jameson Mark J. , Funk Gerry F. 
Published: October 2011

AbstractObjective:To provide a framework for the management of scalp and skull defects.Design:Retrospective chart review.Setting:Two tertiary care hospitals.Patients/Intervention:Fifty‐six consecutive patients who underwent reconstruction of scalp and/or skull defects with free flaps, rotational skin/fascia flaps, skin grafts, and implants. Defects closed primarily and those of the lateral temporal bone and skull base were excluded.Results:Sixty‐two reconstructions were performed. Treatment of skin cancers and intracranial tumors necessitated 31 (50%) and 22 (35%) of the reconstructions, respectively. Defects included partial‐thickness soft tissue (9, 15%), full‐thickness soft tissue (28, 45%), full‐thickness soft tissue and skull (17, 27%), and full‐thickness soft tissue, skull, and dura (8, 13%). Radiation or prereconstruction wound breakdown or infection was involved in 33 (53%) and 25 (40%) of cases, respectively. The most common method of reconstruction was free tissue transfer (27, 44%) followed by local skin (15, 24%) or fascia (9, 15%) flaps. There was a 15% (9/62) complication rate; 89% (8/9) of these occurred in radiated tissues and 44% (4/9) occurred in smokers. Seven of the nine patients with complications (78%) were managed with local wound care and/or removal of an implant, whereas 2 (22%) required a second reconstructive procedure. All patients ultimately achieved a safe outcome with no infection and no bone or dural exposure.Conclusions:In addition to defect location and extent, availability of surrounding tissue and wound healing characteristics direct reconstruction. Patients who receive radiation therapy are at increased risk of complications. Use of vascularized tissue is critical for successful management, making local flaps and free tissue transfer the mainstay of reconstruction. Laryngoscope, 121:2305‐2312, 2011
Minimally invasive transfrontal sinus approach to resection of large tumors of the subfrontal skull base
Authors: Ducic Yadranko , Coimbra Caetano 
Published: October 2011

AbstractObjectives/Hypothesis:To review our favorable experience with a minimally invasive transfrontal sinus approach to tumors of the subfrontal region.Study Design:Retrospective review in a tertiary care referral practice.Methods:Patients undergoing anterior skull base surgery by the senior author (Y.D.) were reviewed and transfrontal sinus approach patients selected for review. All cases of transfrontal sinus approaches to the base of the anterior cranial fossa from 2007 to 2011 were reviewed in a retrospective fashion.Results:A total of 14 cases were noted. Male to female ratio was 10 to 4 with an average age of 58.2 years. The pathologies included: meningioma (n = 6), esthesioneuroblastoma (n = 3), squamous cell carcinoma (n = 3), adenocarcinoma (n = 1), and adenoid cystic carcinoma (n = 1). Five intradural and nine extradural dissections were performed. No major complications were noted, and no patients required conversion to a traditional transfacial approach or required the use of a craniotomy. Twelve patients underwent complete tumor removal, whereas two patients underwent subtotal tumor removal. Reasons for subtotal removal were not access related but rather tumor characteristic related (carotid artery wall involvement, optic chiasm involvement). Contraindication to this approach is the presence of a hypoplastic or aplastic frontal sinus.Conclusions:The minimally invasive transfrontal sinus approach to the subfrontal region provides ready expeditious access to the base of the anterior cranial fossa without the need for brain retraction, craniotomy or naso‐orbital osteotomies. It represents an excellent alternative in the surgical access of both intra‐ and extradural tumors in this region of the skull base. Laryngoscope, 121:2290–2294, 2011
Reconstruction of complex peripheral facial nerve defects by a combined approach using facial nerve interpositional graft and hypoglossal‐facial jump nerve suture
Authors: Volk Gerd Fabian , Pantel Mira , Streppel Michael , Guntinas‐Lichius Orlando 
Published: October 2011

AbstractObjectives/Hypothesis:To describe a modified facial nerve reconstruction technique for complex defects of the facial fan after parotid surgery that avoids synkinesis between upper and lower face.Study Design:Retrospective case series.Methods:Patients who had undergone radical parotidectomy with a large defect of the facial fan, reconstruction of the upper face by facial nerve interpositional graft, and reconstruction of the lower face by hypoglossal‐facial nerve jump nerve suture were included in this series.Results:Four patients underwent the modified combined approach after tumor resection and prior to postoperative radiotherapy in three of the four cases. Surgery was combined with an upper lid weight implantation. Regeneration of the face was successful in all cases within 12 to 16 months. Most important, the separated reanimation of the upper and lower face circumvented synkinesis of the upper and lower face. This factor was essential for good functional results. Using the hypoglossal jump technique instead of a classical cross‐nerve suture technique prevented the sacrifice of ipsilateral tongue function.Conclusions:The presented method offers satisfactory results for facial reanimation and avoids synkinesis between the upper and lower face. Using the jump technique instead of a classic hypoglossal transfer as it was described originally for the combined approach avoids long‐term sequelae for the tongue. Laryngoscope, 121:2402–2405, 2011
Fabrication of Substrates with Defined Mechanical Properties and Topographical Features for the Study of Cell Migration
Authors: Charest Jonathan M. , Califano Joseph P. , Carey Shawn P. , Reinhart‐King Cynthia A. 
Published: October 2011

AbstractBoth substrate topography and substrate mechanical properties are known to influence cell behavior, but little is known about how they act in concert. Here, a method is presented to introduce topographical features into PA hydrogel substrates that span a wide range of physiological E values. Gel swelling plays a significant role in the fidelity of protruding micromolded features, with the most efficient pattern transfer occurring at a crosslinking concentration equal to or greater than ≈5%. In contrast, swelling does not influence the spacing fidelity of microcontact printed islands of collagen on 2D PA substrates. BAECs cultured on micromolded PA substrates exhibit contact guidance along ridges patterned for all E tested.magnified image
Projected numbers of people with movement disorders in the years 2030 and 2050
Authors: Bach Jan‐Philipp , Ziegler Uta , Deuschl Günther , Dodel Richard , Doblhammer‐Reiter Gabriele 
Published: October 2011

AbstractBackground:Movement disorders are chronic diseases with an increasing prevalence in old age. Because these disorders pose a major challenge to patients, families, and health care systems, there is a need for reliable data about the future number of affected people.Patients and Methods:We searched the literature to identify epidemiological studies to obtain age‐specific prevalence data of movement disorders. We combined the age‐specific prevalence data with population projections for Europe, the United States, and Canada.Results:Movement disorders will increase considerably between 2010 and 2050. The highest increase will be for dementia with Lewy bodies. In several countries, we project a near doubling of patients with PD.Conclusions:There will be a strong increase in the number of people affected by most movement disorders between 2010 and 2050. This increase will mostly depend on the future aging of populations in terms of their age structure and future life expectancy. © 2011 Movement Disorder Society
Freezing in Parkinson's disease: A spatiotemporal motor disorder beyond gait
Authors: Vercruysse Sarah , Spildooren Joke , Heremans Elke , Vandenbossche Jochen , Levin Oron , Wenderoth Nicole , Swinnen Stephan P. , Janssens Luc , Vandenberghe Wim , Nieuwboer Alice 
Published: October 2011

AbstractFreezing of gait (FOG) is an incapacitating problem in Parkinson's disease that is difficult to manage therapeutically. We tested the hypothesis that impaired rhythm and amplitude control is a common mechanism of freezing which is also present during other rhythmic tasks. Therefore, we compared the occurrence and spatiotemporal profiles of freezing episodes during upper limb motion, lower limb motion, and FOG. Eleven freezers, 12 non‐freezers, and 11 controls performed a rhythmic bilateral finger movement task. The triggering effect of movement speed, amplitude, and coordination pattern was evaluated. Regression slopes and spectral analysis addressed the spatial and temporal kinematic changes inherent to freezing episodes. The FOG Questionnaire score significantly predicted severity of upper limb freezing, present in 9 freezers, and of foot freezing, present in 8 freezers. Similar to gait, small‐amplitude movements tended to trigger upper limb freezing, which was preceded by hastened movement and a strong amplitude breakdown. Upper limb freezing power spectra were broadband, including increased energy in the “freeze band” (3–8 Hz). Contrary to FOG, unilateral upper limb freezing was common and occurred mainly on the disease‐dominant side. The findings emphasize that a core motor problem underlies freezing which can affect various movement effectors. This deficit may originate on the disease‐dominant body side and interfere with amplitude and timing regulation during repetitive limb movements. These results may shift current thinking on the origins of freezing as being not exclusively a gait failure. © 2011 Movement Disorder Society
Coaxial waveguide MRI
Authors: Alt Stefan , Müller Marco , Umathum Reiner , Bolz Armin , Bachert Peter , Semmler Wolfhard , Bock Michael 
Published: October 2011

AbstractAs ultrahigh‐field MR imaging systems suffer from the standing wave problems of conventional coil designs, the use of antenna systems that generate travelling waves was suggested. As a modification to the original approach, we propose the use of a coaxial waveguide configuration with interrupted inner conductor. This concept can focus the radiofrequency energy to the desired imaging region in the human body and can operate at different Larmor frequencies without hardware modifications, as it is not limited by a lower cut‐off frequency. We assessed the potential of the method with a hardware prototype setup that was loaded with a tissue equivalent phantom and operated with imaging areas of different size. Signal and flip angle distributions within the phantom were analyzed, and imaging at different Larmor frequencies was performed. Results were compared to a finite difference time domain simulation of the setup that additionally provides information on the spatial distribution of the specific absorption rate load. Furthermore, simulation results with a human model (virtual family) are presented. It was found that the proposed method can be used for MRI at multiple frequencies, achieving transmission efficiencies similar to other travelling wave approaches but still suffers from several limitations due to the used mode of wave propagation. Magn Reson Med, 2011. © 2011 Wiley Periodicals, Inc.
Evidence for the presence of high risk human papillomavirus in retinoblastoma tissue from nonfamilial retinoblastoma in developing countries
Authors: Shetty Omshree A. , Naresh Kikkeri N. , Banavali Shripad D. , Shet Tanuja , Joshi Rupali , Qureshi Sajid , Mulherkar Rita , Borges Anita , Desai Sangeeta B. 
Published: October 2011

AbstractBackgroundThe prevalence of human papillomavirus (HPV) infection in India is high. HPV infection is known to cause cervical cancer and has also been implicated in the pathogenesis of retinoblastoma (RB), a common intraocular malignant tumor of childhood which can be familial or sporadic. Despite the high incidence of RB in India, its familial form is rare. Hence this study was undertaken to investigate whether high‐risk HPV types 16 and 18 are involved in the development of RB.MethodsFormalin fixed paraffin embedded RB tissues (n = 76) including prospective cases with corresponding maternal cervical smears (n = 10) were analyzed for the presence of HPV DNA sequences. Expression of the cell cycle regulatory proteins viz; p105, p107, p30, p16, E2F‐1, E2F‐4, and MiB‐1 was studied by immunohistochemistry (IHC) (n = 34).ResultsA total of 53 out of 76 (69.7%) cases were positive for HPV, of these 3 cases were positive for HPV‐16, 23 for HPV‐18, and 27 for both HPV‐16 and ‐18. Of the prospective cases (n = 10) studied, five cases along with the corresponding maternal cervical cytology smear had identical HPV status. HPV‐16 positive tumors were classified as well differentiated (P = 0.013). Nuclear expression of pRB2/p130 showed significant association with HPV‐16 infection (P = 0.04) or dual infection of HPV‐16/‐18 (P = 0.02).ConclusionsOur study lends support to the hypothesis that infection of HPV‐16/‐18 may play an important role in the development of nonfamilial form of RB in children in India. Pediatr Blood Cancer 2012; 58: 185–190. © 2011 Wiley Periodicals, Inc.
Gonadal function and parenthood 20 years after treatment for childhood lymphoma: A cross‐sectional study
Authors: Hamre Hanne , Kiserud Cecilie E. , Ruud Ellen , Thorsby Per M. , Fosså Sophie D. 
Published: October 2011

AbstractBackgroundGonadal function decades after treatment for childhood lymphoma (CL) is not well described. This cross‐sectional study had two aims: (1) describe long‐term gonadal function and fertility in childhood lymphoma survivors (CLSs), and (2) explore anti‐Mullerian hormone (AMH) as a measure of ovarian function in CLSs.ProcedureSeventy‐four male and 62 female CLSs participated in a survey consisting of a questionnaire, clinical examination, and blood/semen analysis. Prior treatment was categorized according to gonadotoxicity. Hypogonadism was determined by levels of gonadal hormones based on luteinizing hormone, follicle‐stimulating hormone, testosterone (males), AMH (females <40 years), and menstrual status. Fertility was explored according to pregnancies achieved, semen analysis, and AMH.ResultsHypogonadism was observed in 7 of 66 males (11%). Seven of 64 males (11%) were categorized as infertile. Nine of 45 females <40 years (20%) were at risk to develop premature ovarian failure (POF). Twenty of 45 females (44%) showed low‐AMH levels indicating decreased fertility. Four “critically low” females reported pregnancies within the preceding 2 years. Sixty‐four percent of the males and 93% of the females attempting parenthood had been successful (P = 0.01). Hypogonadism and low‐AMH were related to treatment burden.ConclusionTwenty years after treatment of CL, female CLSs' attempts of pregnancy initiation are mostly successful, while males seem at higher risk of infertility. Hypogonadism is a problem in 10% of the male CLSs. Based on AMH levels, POF is a risk in 20% of the female CLSs. The clinical significance of AMH reflecting true probability of fertility needs further research in cancer survivors. Pediatr Blood Cancer 2012;59:271–277. © 2011 Wiley Periodicals, Inc.
Early metabolic improvement following bariatric surgery in morbidly obese adolescents
Authors: Teeple E.A. , Teich S. , Schuster D.P. , Michalsky M.P. 
Published: October 2011

AbstractBariatric surgery results in durable weight loss and improved comorbidities. The objectives of this study were to examine the efficacy of gastric bypass in reducing comorbid burden and improving metabolic status among morbidly obese adolescents. The medical records of 15 gastric bypass patients were retrospectively reviewed. Changes in metabolic markers were determined at baseline, 1 and 2 years post‐operatively. Comparative analysis demonstrated significant improvement in weight, BMI, insulin, HbA1C, C‐peptide, %B, %S, IR, cholesterol, percentile cholesterol, TG, percentile TG, HDL, percentile HDL, LDL, percentile LDL, and VLDL. Results support bariatric surgery as a treatment for morbidly obese adolescents with comorbidities. Pediatr Blood Cancer 2012; 58: 112–116. © 2011 Wiley Periodicals, Inc.
Energy balance: An overview with emphasis on children
Authors: Tam Charmaine S. , Ravussin Eric 
Published: October 2011

AbstractChildhood obesity is a significant public health problem, affecting one in five children in the United States. At the crux of this issue is a dysregulation of energy intake and energy expenditure. This review will provide an overview on energy and nutrient balance. We discuss energy balance studies in children using indirect and direct measures, and focus particularly on obesity as a deleterious consequence in childhood survivors of cancer. Obesity affects 11–57% of children with acute lymphoblastic leukemia, probably due to increased energy intake and reduced energy expenditure secondary to reduced habitual activity caused by fatigue. However, most of the studies in children with leukemia are retrospective, use BMI as a measure of obesity, and are inconclusive about the impact of the type of treatment on the development of obesity later in life. To better understand the etiology of obesity in both healthy and sick children, we need to undertake nutrient balance studies with appropriate measures of fat mass and fat distribution while keeping in mind the influence of normal tissue growth and puberty on energy balance. Pediatr Blood Cancer 2012; 58: 154–158. © 2011 Wiley Periodicals, Inc.
On the reported experimental evidence for the quasi‐Fermi level split in quantum‐dot intermediate‐band solar cells
Authors: Abouelsaood Ahmed A. , Ghannam Moustafa Y. , Poortmans Jef 
Published: October 2011

ABSTRACTThe reported experimental evidence for the quasi‐Fermi level split in quantum‐dot intermediate‐band solar cells is carefully examined. It is shown that the separation of the quasi‐Fermi level of the intermediate band from that of the conduction band is not consistent with the experimental results of the quantum efficiency and the luminescence intensity of the InAs/GaAs cells. The fact that the electroluminescence spectrum is too wide, extending much further than we expect on the basis of the measured quantum efficiency in the direction of increasing photon energies, indicates that the temperature of the optically active regions of the cell during the electroluminescence measurements is considerably higher than room temperature. The best agreement with the experimental results is achieved with a temperature of about 525 K. This temperature rise is probably a result of the heating effect of the relatively high forward current used in the luminescence experiments. It is argued that the lack of a quasi‐Fermi level split in this case is associated with the absence of a gap in the emission/absorption spectrum of sub‐bandgap photons. Copyright © 2011 John Wiley & Sons, Ltd.