bluuebunny/crossref_metadata_2025_split huggingface dataset:
Aspects of cognitive activity in schizophrenia
Authors: Tissot R. , Burnand Y. 
Published: July 2009

SYNOPSISThe application of Piaget's genetic psychology tests to schizophrenic patients yielded the following findings. The intelligence quotient of schizophrenics, although within the normal range, is slightly lower than that of a control population of similar age. This is due not to a loss of the operations of the intellect, but to a difficulty experienced by the patients in actualizing the operations. The difficulty is seen particularly in operations dealing with specific objects which require a constant maintenance of the equilibrium between assimilation and accommodation. The thought processes of hebephrenic patients oscillate between excessive assimilation, resulting in a distortion of observable data, and excessive accommodation which by adhering to the observable data distorts the reasoning process. The thought processes of paranoid schizophrenics are dominated by excessive assimilation. This predominance explains their tendency to distort observable data and their difficulty in the generalization of reasoning; it also has an impact on the assimilation/accommodation equilibrium of their logical operations, leading to (a) difficulties in delimiting reflecting abstractions, and therefore the comprehension and extension of concepts, and (b) loss of proof based on logico-mathematical reasoning and, as a result, a propensity to resort to magical thinking and subjective explanations.
Depressed patients with schizophrenic or paranoid symptoms
Authors: Brockington I. F. , Kendell R. E. , Wainwright S. 
Published: July 2009

SYNOPSISFamily history, response to treatment and outcome are reported in a series of 76 patients presenting with both depression and schizophrenic or paranoid symptoms. About 10% of psychotic admissions to the Maudsley and Bethlem Royal Hospitals met a study definition of ‘schizodepressive’ illness. The patients were highly heterogeneous in history, clinical picture and outcome. Many followed a typical schizophrenic course, and others a typical course for affective disorders, but only 4 were given a final diagnosis of manic depressive disease. The best predictors of poor outcome were a mode of onset as an exacerbation of previous psychotic symptoms and the presence of schizophrenic symptoms at some time without depression. The best predictors of good outcome were Stephens' criteria of good prognosis schizophrenia and Kasanin's concept of ‘acute schizo-affective psychosis’. These findings are not easily reconciled with Kraepelin's two entities principle but suggest a continuum of outcome between schizophrenia and unipolar depressive psychosis.
Social desirability, defensiveness and self-report psychiatric inventory scores
Authors: Parkes Katharine R. 
Published: July 2009

SYNOPSISThe effects of social desirability and defensiveness on scores on 2 self-report psychiatric inventories, the General Health Questionnaire (GHQ) and the Middlesex Hospital Questionnaire (MHQ) were investigated in a female subject group assessed for research purposes in an occupational setting. It was found that defensiveness did not affect the reporting of somatic symptoms, but it significantly affected the reporting of all psychological distress. The effect of social desirability was more specific, only the GHQ social dysfunction subscale showing a significant correlation, an effect attributable to the influence of the setting in which the data were obtained.
Reasons and causes: the nature of explanations in Psychology and Psychiatry
Authors: Hill Jonathan 
Published: July 2009

SYNOPSISThe relationship between psychological and biological processes is examined. Criteria for the distinction between reasons and causes are described. These provide a basis for a separation of those mental states and behaviour that can be explained in a reductionist fashion, and those that are not reducible. The proposed conceptual framework has clinical and research implications.
Visual recognition through kinaesthetic mediation
Authors: Landis Theodor , Graves Roger , Benson Frank , Hebben Nancy 
Published: July 2009

SYNOPSISA case is reported in which mercury intoxication produced visual symptoms with an unusual compensation. The similarity of this patient to Schn., a much reported neuropsychiatric case, was striking and prompted correlation of the two cases. Experimental psychological studies performed on the present case provide a basis for an understanding of both cases.
Psychiatric illness following childbirth in Southampton: a case register study
Authors: Nott P. N. 
Published: July 2009

SYNOPSISThe Southampton case register and maternity records were used to identify all Southampton women who had babies in 1976 and 1977 and who had been in psychiatric care in the 2 years before and after the birth date. 127 such women were identified out of a total of 5200 having babies. An analysis of the timing of referral and the total number in care at various stages of the study period confirmed an increased rate of psychosis following childbirth. Rates for other diagnoses showed no such clear relationship. Obstetric and social factors were not related to postpartum morbidity. These results are discussed.
Skin conductance habituation during acute episodes of schizophrenia: qualitative differences from anxious and depressed patients
Authors: Frith Christopher D. , Stevens Marilyn , Johnstone Eve C. , Crow T. J. 
Published: July 2009

SYNOPSISSkin conductance habituation was measured in schizophrenic patients (N = 41) during an acute episode and compared with neurotic patients (N = 86) who were either predominantly anxious or predominantly depressed. All patients were tested before the onset of drug treatment. Between the 14th and 15th tone of the 17 tone simple habituation series a loud ‘dishabituating’ tone was inserted.In terms of traditional measures based on response frequency, non-habituation was most frequent in the anxious patients and least frequent in the depressed patients, with schizophrenic patients being intermediate. However, in terms of response amplitude the schizophrenic patients showed significantly faster habituation than either neurotic group. This paradox seems to be a consequence of the frequency of spontaneous fluctuations which was highly related to habituation status in the schizophrenic group, but not in the neurotic groups. When habituation was defined in terms of response amplitudes falling below spontaneous fluctuation amplitudes (rather than zero) the schizophrenic group showed the lowest frequency of non-habituation.None of the groups showed any evidence of dishabituation after the loud tone, but the schizophrenics showed a significantly smaller response to the loud tone itself. Following Groves & Thompson (1970), this is interpreted as showing that the loud tone induced a greater response because of its perceived difference from the other tones rather than a sensitization effect because of its loudness. In these terms the schizophrenic patients showed greater response generalization than the neurotic patients.
Family history and schizophrenia: characteristics of groups with and without positive family histories
Authors: Shur Eric 
Published: July 2009

SYNOPSISSocial and demographic characteristics were examined retrospectively in a sample of 475 hospitalized schizophrenics to test the hypothesis that they can be meaningfully distinguished by the presence or abesence of psychiatric disorders in their relatives. Cases with a positive family history of psychiatric disorders (FHP cases) were significantly more likely to have been born in the United Kingdom and to have had mothers. Those who had relatives with psychiatric disorders other than schizophrenia were significantly more likely to have been diagnosed as schizo-affective. The findings are thought to reflect a constitutional trait in parents of FHP cases leading to delayed child bearing. They also support the ‘environmental stress’ theory of immigrant psychosis and the hypothesized genetic link between schizo-affective and affective disorders.
Electrodermal activity and therapeutic response to neuroleptic treatment in chronic schizophrenic in-patients
Authors: Schneider Sid J. 
Published: July 2009

SYNOPSISElectrodermal measures, psychiatric ratings (Brief Psychiatric Rating Scale, Clinical Global Impressions) and several Wechsler subtest scores were obtained for 26 hospitalized chronic schizophrenics during drug ‘washout’. The psychiatric ratings and Wechsler scores were obtained again after 6 months' treatment with thiothixene or thioridazine. Results revealed that those patients who displayed therapeutic benefit from the neuroleptic treatment displayed greater pre-treatment electrodermal activity and higher skin conductance levels, compared with schizophrenics who did not benefit. No effect for laterality was noted.
Speech dominance, handedness and electro-convulsions
Authors: Kopelman Micheal D. 
Published: July 2009

SYNOPSISThis paper discusses methods for assessing speech dominance in cases for unilateral ECT. The use of formal laterality tests has been strongly advocated in the literature, but is seldom adopted in clinical practice. Assessment of handwriting type (left/right, inverted/non-inverted) has been put forward as an alternative, but is not valid. Consideration of handedness alone is the most common practice, but is of little value. From current evidence on the relation of handedness to speech dominance, the paper evaluates the likely outcomes of always administering right-sided ECT, and of giving formal tests to left-handers only.
Correlation between plasma levels of prolactin and chlorpromazine in psychiatric patients
Authors: Kolakowska T. , Wiles D. H. , McNeilly A. S. , Gelder M. G. 
Published: July 2009

SynopsisPlasma levels of chlorpromazine (CPZ) and prolactin were measured repeatedly in 14 psychiatric patients throughout CPZ treatment. Mean prolactin level was elevated in 11 subjects (all six women and five of eight men). Mean plasma prolactin correlated significantly with mean plasma CPZ but not with the dose of the drug. Only patients with mean plasma prolactin above 35 ng/ml developed Parkinsonian side-effects.
Cortisol binding in plasma of men with unipolar and bipolar affective disorders
Authors: King David J. 
Published: July 2009

SynopsisFollowing an earlier report, plasma cortisol-binding capacity (CBC) was estimated in a new series of 11 men with unipolar depression and 11 men with bipolar illness admitted to hospital. The two groups were comparable except that the bipolar group tended to have more frequent episodes of illness and to have more family histories of affective disorder. There was no significant difference between the CBC values in each group.
Aspects of the psychology and epidemiology of rheumatoid disease
Authors: Crown Sidney , Crown June M. , Fleming Anthony 
Published: July 2009

SynopsisIn a prospective study of rheumatoid disease (RD) clinical, serological, radiological, and biochemical factors were assessed on 102 patients and scores obtained on the Middlesex Hospital Questionnaire (MHQ). Patients with early RD had MHQ scores closely resembling those in the normal population. Using a new clinical prognostic index, patients who develop severe RD tended to have low scores at initial testing on the MHQ. Patients whose serum was positive for rheumatoid factor also tended to have low scores on the MHQ. Together these findings suggest a possible subclassification of RD into a less severe form in which psychosocial factors may be important, and a more severe form in which heredity or some other constitutional factor (or factors) may be important, rheumatoid factor acting as a ‘marker’.
Psychobiology of partnership behaviour
Authors: Ploog Detlev 
Published: July 2009

SynopsisAnimal experiments demonstrate that it is not only the quality of transmitted and received social signals that is important, but also their frequency and the timing of the information transmitted. In order for progress to be made in the investigation of human social behaviour and its disorders, methods must be developed which allow the transmission of verbal and non-verbal information to be measured. Experiments carried out with healthy adults and healthy and disturbed children to investigate human eye contact and distance behaviour are reported, along with experiments on the influence of gaze and body posture on spoken communication. Finally, a report on the use of behaviour therapy for an autistic child is outlined in order to explore the psychobiological correlations between social behaviour and language, which concur with extensive experiments on brain stimulation. It is suggested that there is a cerebral representation for species-specific social behaviour and a vocalization system embedded in these brain structures which is a phylogenetically patterned prerequisite for the development of human language.
Thyrotropin releasing hormone (TRH) as a possible quick-acting but short-lasting antidepressant
Authors: Van Den Burg W. , Van Praag H. M. , Bos E. R. H. , Piers D. A. , Van Zanten A. K. , Doorenbos H. 
Published: July 2009

SynopsisIn a double reversal design the potency of thyrotropin releasing hormone (TRH) (500 μgintravenously) as a quick-acting antidepressive agent was evaluated. A first injection did seem to give rise to a very slight short-lasting effect, though this could not be ascertained clearly. There were no visible effects after a second injection. The thyroid stimulating hormone (TSH) response curve after TRH administration in the depressive patients group was blunted in comparison with that in a matched control group of normals.
Litterfall patterns in a tropical deciduous forest in Mexico over a five-year period
Authors: Martínez-Yrízar Angelina , Sarukhán Jose 
Published: July 2009

ABSTRACTContinuous litterfall measurements were made from 1977 to 1982, at two sites with contrasting topography in a mature tropical deciduous forest in Chamela, Jalisco, on the Pacific Coast of Mexico (19° 30′ N, 105° 03′ W). The climate is strongly seasonal with the annual rainfall (x = 748 mm) concentrated in six months (June to November) and a mean annual temperature of 24.9°C. Results of the five-year study show that at the Valley Site (slope <5°) the mean annual litterfall was 6.58 ±0.15 (SE) Mg ha−1y−1composed of 73.3% leaves, 17.1% woody material, 5.6% reproductive remains and 4.0% finely fragmented debris. At the Hill Site (slope 20°–40°) mean annual litterfall was 3.95 ± 0.16 Mg ha−1y−1, consisting of 68.8% leaves, 17.0% woody material, 9.4% reproductive remains and 4.7% fragmented debris. At the Valley Site the year-to-year variation in total litterfall was not significant. In contrast, at the Hill Site it fluctuated markedly from year to year. Litter production exhibited a pronounced seasonally: at the Hill Site total litterfall peaked near the onset of the dry season; at the Valley Site it occurred two months later, apparently as a result of differences in soil moisture availability between the study sites.
Measurements of adipocity and high blood pressure among children and adolescents living in Belo Horizonte
Authors: Ribeiro Robespierre C. , Lamounier Joel A. , Oliveira Reynaldo G. , Bensenor Isabela M. , Lotufo Paulo A. 
Published: July 2009

AbstractObjectiveTo verify an association, if it exists, between obesity and blood pressure raised beyond the 90th percentile in children and adolescents, and to determine the measure of adiposity that best correlates with blood pressure in these subjects.DesignCross-sectional study.SettingA school-based study in Belo Horizonte, Brazil.ParticipantsWe selected randomly 1,403 students, aged from 6 to 18 years, from 545,046 students attending 521 public and private schools. Those selected completed the study.Main measures of outcomeWe recorded the weight, height, skin fold in the triceps, subscapular, and suprailiac areas, waist and hip circumference, body-mass index, and resting systolic and diastolic blood pressures using a mercury sphygmomanometer.ResultsIn univariate analyses, body mass index greater or lesser than 85th percentile, measurements of skin thickness in the subscapular and suprailiac areas, and the sum of all measurements of skinfold thickness, were associated with both systolic and diastolic measurements of blood pressure. After multivariate analyses that adjusted for all measurements of adiposity except itself, and age, race, and socioeconomic state, we found that the increased body mass index was associated with a 3.6-fold increased frequency of elevated systolic measurements of blood pressure, with 95% confidence intervals from 2.2 to 5.8, and a 2.7-fold increased frequency of elevated measurements of diastolic blood pressure, with 95% confidence intervals from 1.9 to 4.0.ConclusionsBody-mass index serves as a better predictor of elevated blood pressure among children than do local measurements of adiposity.
Pancreatic stellate cells can form new β-like cells
Authors: Docherty Kevin 
Published: July 2009

Regenerative medicine, including cell-replacement strategies, may have an important role in the treatment of Type 1 and Type 2 diabetes, both of which are associated with decreased islet cell mass. To date, significant progress has been made in deriving insulin-secreting β-like cells from human ES (embryonic stem) cells. However, the cells are not fully differentiated, and there is a long way to go before they could be used as a replenishable supply of insulin-secreting β-cells for transplantation. For this reason, adult pancreatic stem cells are seen as an alternative source that could be expanded and differentiated ex vivo, or induced to form new islets in situ. In this issue of the Biochemical Journal, Mato et al. used drug selection to purify a population of stellate cells from explant cultures of pancreas from lactating rats. The selected cells express some stem-cell markers and can be grown for over 2 years as a fibroblast-like monolayer. When plated on extracellular matrix, along with a cocktail of growth factors that included insulin, transferrin, selenium and the GLP-1 (glucagon-like peptide-1) analogue exendin-4, the cells differentiated into cells that expressed many of the phenotypic markers characteristic of a β-cell, and exhibited an insulin-secretory response, albeit weak, to glucose. The ability to purify this cell population opens up the possibility of unravelling the mechanisms that control self-renewal and differentiation of pancreatic cells that share some of the properties of stem cells.
Promoting assembly and bundling of FtsZ as a strategy to inhibit bacterial cell division: a new approach for developing novel antibacterial drugs
Authors: Beuria Tushar K. , Singh Parminder , Surolia Avadhesha , Panda Dulal 
Published: July 2009

FtsZ plays an essential role in bacterial cell division. We have used the assembly of FtsZ as a screen to find antibacterial agents with a novel mechanism of action. The effects of 81 compounds of 29 different structural scaffolds on FtsZ assembly in vitro were examined using a sedimentation assay. Out of these 81 compounds, OTBA (3-{5-[4-oxo-2-thioxo-3-(3-trifluoromethyl-phenyl)-thiazolidin-5-ylidenemethyl]-furan-2-yl}-benzoic acid) was found to promote FtsZ assembly in vitro. OTBA increased the assembly of FtsZ, caused bundling of FtsZ protofilaments, prevented dilution-induced disassembly of FtsZ protofilaments and decreased the GTPase activity in vitro. It bound to FtsZ with an apparent dissociation constant of 15±1.5 μM. Furthermore, OTBA inhibited the proliferation of Bacillus subtilis 168 cells with an MIC (minimum inhibitory concentration) of 2 μM, whereas it exerted minimal effects on mammalian cell proliferation, indicating that it might have a potential use as an antibacterial drug. In the effective proliferation inhibitory concentration range, OTBA induced filamentation in bacteria and also perturbed the formation of the cytokinetic Z-rings in bacteria. However, the agent neither perturbed the membrane structures nor affected the nucleoid segregation in B. subtilis cells. The results suggested that the OTBA inhibited bacterial cytokinesis by perturbing the formation and functioning of the Z-ring via altering FtsZ assembly dynamics. The antibacterial mechanism of action of OTBA is similar to that of the widely used anticancer drug paclitaxel, which inhibits cancer cell proliferation by promoting the assembly of tubulin, a eukaryotic homologue of FtsZ.
Matrix metalloproteinase-2 predicts mortality in patients with acute coronary syndrome
Authors: Dhillon Onkar S. , Khan Sohail Q. , Narayan Hafid K. , Ng Kelvin H. , Mohammed Noor , Quinn Paulene A. , Squire Iain B. , Davies Joan E. , Ng Leong L. 
Published: July 2009

The aim of the present study was to investigate the predictive value of MMP (matrix metalloproteinase)-2, MMP-3 and MMP-9 levels in patients with acute coronary syndrome for death, readmission with HF (heart failure) or recurrent MI (myocardial infarction) and to compare them with established markers, NT-proBNP (N-terminal pro-B-type natriuretic peptide) and the GRACE (Global Registry of Acute Coronary Events) score. A single blood test was taken 4 days after admission in 1024 consecutive patients with acute MI with end points observed over 519 (134–1059) days [value is median (range)]. MMP-2 and MMP-3 were increased in patients who died (n=111) compared with survivors (P&lt;0.006 and P=0.01 respectively), but were similar in patients with HF (n=106) or MI (n=138). MMP-9 levels were similar across study end points. Using Cox proportional hazards modelling, MMP-2 demonstrated an independent prediction of death [HR (hazard ratio) 6.60, P=0.001], along with NT-proBNP (HR 4.62, P&lt;0.001) and the GRACE score (HR 1.03, P&lt;0.001), but MMP-3, MMP-9 or log10-troponin I did not. For 1 year mortality, the areas under the receiver operating characteristic curves were 0.60 and 0.58 for MMP-2 and MMP-3 respectively, compared with 0.82 for NT-proBNP and 0.84 for the GRACE score (all P&lt;0.001). Kaplan–Meier analysis revealed that MMP-2 levels in the top quartile were associated with higher mortality rates (log rank 12.49, P=0.006). On univariate analysis, MMP-2 and MMP-3 had a weak association with HF readmission, which was lost after adjustment for clinical factors. None of the MMPs tested predicted MI. In conclusion, this is the first single centre study that identifies MMP2 as an independent predictor of all-cause mortality post-ACS (acute coronary syndrome); however, NT-proBNP and the GRACE score are superior for risk stratification in this cohort.
Lumpers or splitters? Evaluating recovery and management plans for metapopulations of herring
Authors: Kell Laurence T. , Dickey-Collas Mark , Hintzen Niels T. , Nash Richard D. M. , Pilling Graham M. , Roel Beatriz A. 
Published: July 2009

Abstract
Kell, L. T., Dickey-Collas, M., Hintzen, N. T., Nash, R. D. M., Pilling, G. M., and Roel, B. A. 2009. Lumpers or splitters? Evaluating recovery and management plans for metapopulations of herring. – ICES Journal of Marine Science, 66: 1776–1783. The long-term management of a stock representing a metapopulation has been simulated in a case study loosely based upon herring to the west of the British isles, where stocks are currently assessed and managed by management area, although there is evidence of mixing between stocks (in terms of connectivity, migrations, and exploitation). The simulations evaluate scientific advice (based on virtual population analysis, VPA) and the sustainability of fishing under two population-structure scenarios, corresponding either to discrete stocks, which only mix on the feeding grounds, or where diffusion between stocks takes place. The ability of stock assessment to monitor stock status and exploitation levels was evaluated for defining stocks based on fishing areas and for stocks that combined fishing areas. The study showed that assessment based on VPA of the metapopulation could fail to detect overexploitation of stocks and fail to detect and distinguish between the effects of exploitation and regime shifts.