bluuebunny/crossref_metadata_2025_split huggingface dataset:
Differential Contributions of Bilateral Ventral Anterior Temporal Lobe and Left Anterior Superior Temporal Gyrus to Semantic Processes
Authors: Visser M. , Lambon Ralph M. A. 
Published: March 2011

Abstract
Studies of semantic dementia and repetitive TMS have suggested that the bilateral anterior temporal lobes (ATLs) underpin a modality-invariant representational hub within the semantic system. However, it is not clear whether all ATL subregions contribute in the same way. We utilized distortion-corrected fMRI to investigate the pattern of activation in the left and right ATL when participants performed a semantic decision task on auditory words, environmental sounds, or pictures. This showed that the ATL is not functionally homogeneous but is more graded. Both left and right ventral ATL (vATL) responded to all modalities in keeping with the notion that this region underpins multimodality semantic processing. In addition, there were graded differences across the hemispheres. Semantic processing of both picture and environmental sound stimuli was associated with equivalent bilateral vATL activation, whereas auditory words generated greater activation in left than right vATL. This graded specialization for auditory stimuli would appear to reflect the input from the left superior ATL, which responded solely to semantic decisions on the basis of spoken words and environmental sounds, suggesting that this region is specialized to auditory stimuli. A final noteworthy result was that these regions were activated for domain level decisions to singly presented stimuli, which appears to be incompatible with the hypotheses that the ATL is dedicated (a) to the representation of specific entities or (b) for combinatorial semantic processes.
Interactions within and between Corticostriatal Loops during Component Processes of Category Learning
Authors: Lopez-Paniagua Dan , Seger Carol A. 
Published: March 2011

AbstractWe examined dynamic interactions between cortex and BG during stimulus–response and feedback processing phases of categorization. First, we dissociated stimulus–response processing from feedback processing using “jittered” intervals of time between response and feedback to examine how each recruits the four primary corticostriatal loops (motor, executive, visual, and motivational). Second, we examined dynamic interactions within and between corticostriatal loops using Granger causality mapping. On each trial, subjects viewed one of six abstract visual stimuli, pressed a button indicating category membership, and then received feedback as to whether the decision was right or wrong. Stimulus–response processing was associated with greater activity in the visual loop, whereas feedback processing resulted in activity in the executive loop that was sensitive to feedback valence. Granger causality mapping showed patterns of directed influence within corticostriatal loops and between loops from the motor to the executive, to the visual, and finally to the motivational loop. These patterns of interaction are consistent with functional integration of motor processing in the motor loop with feedback processing in the executive loop and maintenance of stimulus–response history for future responses in the motivational loop.
The Default Network Distinguishes Construals of Proximal versus Distal Events
Authors: Tamir Diana I. , Mitchell Jason P. 
Published: March 2011

Abstract
Humans enjoy a singular capacity to imagine events that differ from the “here-and-now.” Recent cognitive neuroscience research has linked such simulation processes to the brain's “default network.” However, extant cognitive theories suggest that perceivers reliably simulate only relatively proximal experiences—those that seem nearby, soon, likely to happen, or relevant to a close other. Here, we test these claims by examining spontaneous engagement of the default network while perceivers consider experiencing events from proximal and distal perspectives. Across manipulations of perspective in four dimensions, two regions of the default network—medial prefrontal cortex and retrosplenial cortex—were more active for proximal than distal events, supporting cognitive accounts that perceivers only richly simulate experiences that seem immediate and that perceivers represent different dimensions of distance similarly. Moreover, stable individual differences in default activity when thinking about distal events correlated with individual variability in an implicit measure of psychological distance, suggesting that perceivers naturally vary in their tendency to simulate far-off or unlikely experiences.
Virtual subjective pilling evaluation: an alternative
Authors: de Oliveira Mendes António , Torrão Fiadeiro Paulo , Lopes Miguel Rui Alberto 
Published: March 2011

This paper reports an alternative approach for the evaluation of fabric pilling. On this approach, orthogonal projections of the three-dimensional (3D) fabric images are used directly to virtually evaluate the pilling formation of the fabrics. The 3D images of the fabrics are obtained through the reconstruction of the topography of the real textile fabrics. For that, a dual-scanning optical system (triangulation system) was used, which was developed and implemented by our research team. This evaluation approach is performed by comparing the appearance of the orthogonal projections of the 3D fabric images with the same photographic standard sets used in the conventional subjective method. For the validation of the obtained results with this methodology, a comparison was carried out relative to a reference subjective evaluation. This reference evaluation corresponds to a subjective evaluation of the fabrics originally performed by a panel of experts. A comparison was also performed between the results obtained with this methodology and those obtained by an objective evaluation. This objective evaluation corresponds to the automatic attribution of the equivalent pilling grade to the fabrics, based on the calculation of the total volume of pilling formed in their surfaces. The final results obtained with the described methodology were showed to be globally in agreement with both the reference subjective and the objective evaluations. Subsequently, this method shows potential as an alternative approach for the virtual subjective evaluation of fabric pilling.
A Prospective Study of Snowkiting Injuries
Authors: Moroder Philipp , Runer Armin , Hoffelner Thomas , Frick Nora , Resch Herbert , Tauber Mark 
Published: March 2011

Background: Snowkiting is becoming an increasingly popular extreme sport; however, its injury rates and patterns are unknown to date. Purpose: The authors surveyed the injuries in a group of snowkiters over 1 season. Study Design: Descriptive epidemiology study. Methods: The study was conducted over the course of 1 winter season ranging from November 2009 until March 2010; 80 snowkiters were surveyed prospectively. All participants were recruited through contacts with snowkite schools, snowkiting-related web portals, or Internet-based social networks. Results: During 3929 hours of snowkiting recorded, 33 injuries occurred, of which 60.6% were mild; 21.2%, moderate; and 18.2%, severe. The calculated injury rate was 8.4 injuries per 1000 hours of exposure. Most frequently injured body sites were the back (30.3%), knee (24.2%), shoulder (21.2%), and head (21.2%). Upper extremity injuries included 2 shoulder dislocations, a clavicle fracture, and a dislocation fracture of the radial head. Injuries to the lower extremity included 3 knee sprains and 1 anterior cruciate ligament rupture. The most common injury causes were riding errors (75.8%), wind gusts (36.4%), and poor snow conditions (27.3%). When compared with experts (5.1 injuries per 1000 hours of exposure), beginners (20.8 injuries per 1000 hours of exposure) had a significantly increased risk of getting injured (odds ratio [OR] 4.11; 95% confidence interval [CI], 1.34-12.64; P = .008). Athletes who used snowboards for snowkiting purposes were injured almost 3 times more frequently than their colleagues using skis (11.7 vs 4.1 injuries per 1000 hours of exposure; OR 2.85; 95% CI, 1.23-6.57; P = .010). The quick-release system (97.5%), helmet (92.5%), kite leash (83.8%), spine protector (51.3%), and shoulder protectors (20.0%) were the most commonly used protective/safety equipment. Conclusion: Snowkiting can be considered a sport carrying a high risk of injury. More caution in assessing local snow conditions and wind gust occurrences is recommended as well as considering using the help and advice of a professional instructor when beginning this action-packed sport. Injury prevention strategies should also include the further improvement of currently available safety equipment.
Etanercept Enhances Preservation of Osteochondral Allograft Viability
Authors: Linn Michael S. , Chase Derek C. , Healey Robert M. , Harwood Frederick L. , Bugbee William D. , Amiel David 
Published: March 2011

Background: Osteochondral allografts are an increasingly popular treatment for the repair of articular cartilage lesions. Current tissue bank protocols require bacteriological testing that takes from 21 to 28 days to process. During this time, tumor necrosis factor–alpha (TNF-α, a proapoptotic cytokine) is upregulated, resulting in loss of chondrocyte viability. To date, etanercept (a cytokine inhibitor) has not been studied in the current storage paradigm with the intention of preserving cell viability. Purpose: This study was undertaken to assess whether the addition of etanercept can improve the chondrocyte viability ofosteochondral allograft during storage. Study Design: Controlled laboratory study. Methods: Osteochondral allografts were harvested from 8 Boer goat femurs and placed into storage media and stored at 4°C for 28 days. The experimental group was supplemented with 10 µg/mL of etanercept. After storage, cell viability was assessed by live/dead staining and confocal microscopy. Specimens were also analyzed histologically and underwent histomorphologic analysis. TNF-α expression was measured with semiquantitative polymerase chain reaction. Results: At 28 days, the percentage viability of the superficial zone in etanercept-treated allografts was maintained at significantly higher levels than those measured in the untreated group (69.3 ± 9.4 compared with 47.8 ± 19.1, P = .01). No difference was found histologically between the etanercept and the untreated group (ie, safranin O staining for glycosaminoglycan expression). Histomorphologic assessment showed no difference in indentation stiffness or roughness between groups. TNF-α expression was significantly decreased in the etanercept group compared to the untreated group. Conclusion: Etanercept was able to maintain cell viability of osteochondral allografts significantly better than the current storage paradigm after 28 days of storage. Clinical Relevance: Maintaining the viability of the superficial zone will benefit outcomes by facilitating joint articulation via improved lubrication. Additionally, maintaining the cellular viability for increased periods of time may allow a greater window of time in which a suitable recipient may be found.
Effects of ambient temperature, humidity, and other meteorological variables on hospital admissions for angina pectoris
Authors: Abrignani Maurizio G , Corrao Salvatore , Biondo Giovan B , Lombardo Renzo M , Di Girolamo Paola , Braschi Annabella , Di Girolamo Alberto , Novo Salvatore 
Published: March 2011

Background: Seasonal peaks in cardiovascular disease incidence have been widely reported, suggesting weather has a role. Design The aim of our study was to determine the influence of climatic variables on angina pectoris hospital admissions. Methods: We correlated the daily number of angina cases admitted to a western Sicilian hospital over a period of 12 years and local weather conditions (temperature, humidity, wind force and direction, precipitation, sunny hours and atmospheric pressure) on a day-to-day basis. A total of 2459 consecutive patients were admitted over the period 1987–1998 (1562 men, 867 women; M/F – 1:8). Results: A seasonal variation was found with a noticeable winter peak. The results of Multivariate Poisson analysis showed a significant association between the daily number of angina hospital admission, temperature, and humidity. Significant incidence relative ratios (95% confidence intervals/measure unit) were, in males, 0.988 (0.980–0.996) ( p = 0.004) for minimal temperature, 0.990 (0.984–0.996) ( p = 0.001) for maximal humidity, and 1.002 (1.000–1.004) ( p = 0.045) for minimal humidity. The corresponding values in females were 0.973 (0.951–0.995) ( p < 0.017) for maximal temperature and 1.024 (1.001–1.048) ( p = 0.037) for minimal temperature. Conclusions: Environmental temperature and humidity may play an important role in the pathogenesis of angina, although it seems different according to the gender. These data may help to understand the mechanisms that trigger ischemic events and to better organize hospital assistance throughout the year.
Activin A skews macrophage polarization by promoting a proinflammatory phenotype and inhibiting the acquisition of anti-inflammatory macrophage markers
Authors: Sierra-Filardi Elena , Puig-Kröger Amaya , Blanco Francisco J. , Nieto Concha , Bragado Rafael , Palomero M. Isabel , Bernabéu Carmelo , Vega Miguel A. , Corbí Angel L. 
Published: March 2011

AbstractM-CSF favors the generation of folate receptor β–positive (FRβ+), IL-10–producing, immunosuppressive, M2-polarized macrophages [M2 (M-CSF)], whereas GM-CSF promotes a proinflammatory, M1-polarized phenotype [M1 (GM-CSF)]. In the present study, we found that activin A was preferentially released by M1 (GM-CSF) macrophages, impaired the acquisition of FRβ and other M2 (M-CSF)–specific markers, down-modulated the LPS-induced release of IL-10, and mediated the tumor cell growth–inhibitory activity of M1 (GM-CSF) macrophages, in which Smad2/3 is constitutively phosphorylated. The contribution of activin A to M1 (GM-CSF) macrophage polarization was evidenced by the capacity of a blocking anti–activin A antibody to reduce M1 (GM-CSF) polarization markers expression while enhancing FRβ and other M2 (M-CSF) markers mRNA levels. Moreover, an inhibitor of activin receptor-like kinase 4/5/7 (ALK4/5/7 or SB431542) promoted M2 (M-CSF) marker expression but limited the acquisition of M1 (GM-CSF) polarization markers, suggesting a role for Smad2/3 activation in macrophage polarization. In agreement with these results, expression of activin A and M2 (M-CSF)–specific markers was oppositely regulated by tumor ascites. Therefore, activin A contributes to the proinflammatory macrophage polarization triggered by GM-CSF and limits the acquisition of the anti-inflammatory phenotype in a Smad2-dependent manner. Our results demonstrate that activin A–initiated Smad signaling skews macrophage polarization toward the acquisition of a proinflammatory phenotype.
Structural insights into the extracellular assembly of the hematopoietic Flt3 signaling complex
Authors: Verstraete Kenneth , Vandriessche Gonzalez , Januar Mariska , Elegheert Jonathan , Shkumatov Alexander V. , Desfosses Ambroise , Van Craenenbroeck Kathleen , Svergun Dmitri I. , Gutsche Irina , Vergauwen Bjorn , Savvides Savvas N. 
Published: March 2011

AbstractThe class III receptor tyrosine kinase (RTKIII) Fms-like tyrosine kinase receptor 3 (Flt3) and its cytokine ligand (FL) play central roles in hematopoiesis and the immune system, by establishing signaling cascades crucial for the development and homeostasis of hematopoietic progenitors and antigen-presenting dendritic cells. However, Flt3 is also one of the most frequently mutated receptors in hematologic malignancies and is currently a major prognostic factor and clinical target for acute myeloid leukemia. Here, we report the structural basis for the Flt3 ligand-receptor complex and unveil an unanticipated extracellular assembly unlike any other RTKIII/V complex characterized to date. FL induces dimerization of Flt3 via a remarkably compact binding epitope localized at the tip of extracellular domain 3 of Flt3, and it invokes a ternary complex devoid of homotypic receptor interactions. Comparisons of Flt3 with homologous receptors and available mutagenesis data for FL have allowed us to rationalize the unique features of the Flt3 extracellular assembly. Furthermore, thermodynamic dissection of complex formation points to a pronounced enthalpically driven binding event coupled to an entropic penalty. Together, our data suggest that the high-affinity Flt3:FL complex is driven in part by a single preformed binding epitope on FL reminiscent of a “lock-and-key” binding mode, thereby setting the stage for antagonist design.
Mitogenomic phylogenetic analyses of the Delphinidae with an emphasis on the Globicephalinae
Authors: Vilstrup Julia T , Ho Simon YW , Foote Andrew D , Morin Phillip A , Kreb Danielle , Krützen Michael , Parra Guido J , Robertson Kelly M , de Stephanis Renaud , Verborgh Philippe , Willerslev Eske , Orlando Ludovic , Gilbert M Thomas P 
Published: March 2011

Abstract

Background
Previous DNA-based phylogenetic studies of the Delphinidae family suggest it has undergone rapid diversification, as characterised by unresolved and poorly supported taxonomic relationships (polytomies) for some of the species within this group. Using an increased amount of sequence data we test between alternative hypotheses of soft polytomies caused by rapid speciation, slow evolutionary rate and/or insufficient sequence data, and hard polytomies caused by simultaneous speciation within this family. Combining the mitogenome sequences of five new and 12 previously published species within the Delphinidae, we used Bayesian and maximum-likelihood methods to estimate the phylogeny from partitioned and unpartitioned mitogenome sequences. Further ad hoc tests were then conducted to estimate the support for alternative topologies.

Results
We found high support for all the relationships within our reconstructed phylogenies, and topologies were consistent between the Bayesian and maximum-likelihood trees inferred from partitioned and unpartitioned data. Resolved relationships included the placement of the killer whale (Orcinus orca) as sister taxon to the rest of the Globicephalinae subfamily, placement of the Risso's dolphin (Grampus griseus) within the Globicephalinae subfamily, removal of the white-beaked dolphin (Lagenorhynchus albirostris) from the Delphininae subfamily and the placement of the rough-toothed dolphin (Steno bredanensis) as sister taxon to the rest of the Delphininae subfamily rather than within the Globicephalinae subfamily. The additional testing of alternative topologies allowed us to reject all other putative relationships, with the exception that we were unable to reject the hypothesis that the relationship between L. albirostris and the Globicephalinae and Delphininae subfamilies was polytomic.

Conclusion
Despite their rapid diversification, the increased sequence data yielded by mitogenomes enables the resolution of a strongly supported, bifurcating phylogeny, and a chronology of the divergences within the Delphinidae family. This highlights the benefits and potential application of large mitogenome datasets to resolve long-standing phylogenetic uncertainties.
QTL mapping in white spruce: gene maps and genomic regions underlying adaptive traits across pedigrees, years and environments
Authors: Pelgas Betty , Bousquet Jean , Meirmans Patrick G , Ritland Kermit , Isabel Nathalie 
Published: March 2011

Abstract

Background
The genomic architecture of bud phenology and height growth remains poorly known in most forest trees. In non model species, QTL studies have shown limited application because most often QTL data could not be validated from one experiment to another. The aim of our study was to overcome this limitation by basing QTL detection on the construction of genetic maps highly-enriched in gene markers, and by assessing QTLs across pedigrees, years, and environments.

Results
Four saturated individual linkage maps representing two unrelated mapping populations of 260 and 500 clonally replicated progeny were assembled from 471 to 570 markers, including from 283 to 451 gene SNPs obtained using a multiplexed genotyping assay. Thence, a composite linkage map was assembled with 836 gene markers.
For individual linkage maps, a total of 33 distinct quantitative trait loci (QTLs) were observed for bud flush, 52 for bud set, and 52 for height growth. For the composite map, the corresponding numbers of QTL clusters were 11, 13, and 10. About 20% of QTLs were replicated between the two mapping populations and nearly 50% revealed spatial and/or temporal stability. Three to four occurrences of overlapping QTLs between characters were noted, indicating regions with potential pleiotropic effects. Moreover, some of the genes involved in the QTLs were also underlined by recent genome scans or expression profile studies.
Overall, the proportion of phenotypic variance explained by each QTL ranged from 3.0 to 16.4% for bud flush, from 2.7 to 22.2% for bud set, and from 2.5 to 10.5% for height growth. Up to 70% of the total character variance could be accounted for by QTLs for bud flush or bud set, and up to 59% for height growth.

Conclusions
This study provides a basic understanding of the genomic architecture related to bud flush, bud set, and height growth in a conifer species, and a useful indicator to compare with Angiosperms. It will serve as a basic reference to functional and association genetic studies of adaptation and growth in Picea taxa. The putative QTNs identified will be tested for associations in natural populations, with potential applications in molecular breeding and gene conservation programs. QTLs mapping consistently across years and environments could also be the most important targets for breeding, because they represent genomic regions that may be least affected by G × E interactions.
Association between Frequency Domain Heart Rate Variability and Unplanned Readmission to Hospital in Geriatric Patients
Authors: Chiang Jui-Kun , Fu Chin-Hua , Kuo Terry BJ , Koo Malcolm 
Published: March 2011

AbstractBackgroundAn accurate prediction of unplanned readmission (UR) after discharge from hospital can facilitate physician's decision making processes for providing better quality of care in geriatric patients. The objective of this study was to explore the association of cardiac autonomic functions as measured by frequency domain heart rate variability (HRV) and 14-day UR in geriatric patients.MethodsPatients admitted to the geriatric ward of a regional hospital in Chiayi county in Taiwan were followed prospectively from July 2006 to June 2007. Those with invasive tubes and those who were heavy smokers, heavy alcohol drinkers, on medications that might influence HRV, or previously admitted to the hospital within 30 days were excluded. Cardiac autonomic functions were evaluated by frequency domain indices of HRV. Multiple logistic regression was used to assess the association between UR and HRV indices adjusted for age and length of hospitalization.ResultsA total of 78 patients met the inclusion criteria and 15 of them were readmitted within 14 days after discharge. The risk of UR was significantly higher in patients with lower levels of total power (OR = 1.39; 95% CI = 1.04-2.00), low frequency power (LF) (OR = 1.22; 95% CI = 1.03-1.49), high frequency power (HF) (OR = 1.27; 95% CI = 1.02-1.64), and lower ratios of low frequency power to high frequency power (LF/HF ratio) (OR = 1.96; 95% CI = 1.07-3.84).ConclusionThis is the first study to evaluate the association between frequency domain heart rate variability and the risk of UR in geriatric patients. Frequency domain heart rate variability indices measured on admission were significantly associated with increased risk of UR in geriatric patients. Additional studies are required to confirm the value and feasibility of using HRV indices on admission as a non-invasive tool to assist the prediction of UR in geriatric patients.