bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Candidate Gene Study of Folate-Associated One Carbon Metabolism Genes and Colorectal Cancer Risk
Authors: Levine A. Joan , Figueiredo Jane C. , Lee Won , Conti David V. , Kennedy Kathleen , Duggan David J. , Poynter Jenny N. , Campbell Peter T. , Newcomb Polly , Martinez Maria Elena , Hopper John L. , Le Marchand Loic , Baron John A. , Limburg Paul J. , Ulrich Cornelia M. , Haile Robert W. 
Published: July 2010

AbstractBackground: Folate-associated one-carbon metabolism (FOCM) may play an important role in colorectal carcinogenesis. Variation in FOCM genes may explain some of the underlying risk of colorectal cancer.Methods: This study utilized data from 1,805 population-based colorectal cancer cases and 2,878 matched sibling controls from the Colon Cancer Family Registry. We used a comprehensive haplotype tagging single nucleotide polymorphism (tagSNP) approach to select 395 tagSNPs in 15 genes involved in folate and vitamin B12 metabolism. Genotyping was done using the Illumina GoldenGate or Sequenom platforms. Risk factor and dietary data were collected using self-completed questionnaires. Microsatellite instability (MSI) status was determined using standard techniques, and tumor subsite was obtained from pathology reports. The association between SNPs and colorectal cancer was assessed using conditional logistic regression with sibships as the matching factor and assuming a log additive or codominant model.Results: In the log additive model, two linked (r2 = 0.99) tagSNPs in the DHFR gene (rs1677693 and rs1643659) were associated with a significant decrease in colorectal cancer risk after correction for multiple testing (odds ratio, 0.87; 95% confidence interval, 0.71-0.94; P = 0.029; and odds ratio, 0.87; 95% confidence interval, 0.71-0.95; P = 0.034 for rs1677693 and rs1643659, respectively). These two linked (r2 = 0.99) tagSNPs and one tagSNP in the MTR gene (rs4659744) were significantly associated with reduced colorectal cancer risk only among individuals not using multivitamin supplements.Conclusions: Overall, we found only moderate evidence that genetic variation in 15 folate pathway genes may affect colorectal cancer risk except in non–multivitamin users.Impact: This study suggests that multivitamin supplement use may modify the association between folate pathway genes and colorectal cancer risk in a post-folic-acid-supplemented population. Cancer Epidemiol Biomarkers Prev; 19(7); 1812–21. ©2010 AACR.
Coffee and Tea Intake and Risk of Head and Neck Cancer: Pooled Analysis in the International Head and Neck Cancer Epidemiology Consortium
Authors: Galeone Carlotta , Tavani Alessandra , Pelucchi Claudio , Turati Federica , Winn Deborah M. , Levi Fabio , Yu Guo-Pei , Morgenstern Hal , Kelsey Karl , Dal Maso Luigino , Purdue Mark P. , McClean Michael , Talamini Renato , Hayes Richard B. , Franceschi Silvia , Schantz Stimson , Zhang Zuo-Feng , Ferro Gilles , Chuang Shu-Chun , Boffetta Paolo , La Vecchia Carlo , Hashibe Mia 
Published: July 2010

Abstract
Background: Only a few studies have explored the relation between coffee and tea intake and head and neck cancers, with inconsistent results.
Methods: We pooled individual-level data from nine case-control studies of head and neck cancers, including 5,139 cases and 9,028 controls. Logistic regression was used to estimate odds ratios (OR) and 95% confidence intervals (95% CI), adjusting for potential confounders.
Results: Caffeinated coffee intake was inversely related with the risk of cancer of the oral cavity and pharynx: the ORs were 0.96 (95% CI, 0.94–0.98) for an increment of 1 cup per day and 0.61 (95% CI, 0.47–0.80) in drinkers of &gt;4 cups per day versus nondrinkers. This latter estimate was consistent for different anatomic sites (OR, 0.46; 95% CI, 0.30–0.71 for oral cavity; OR, 0.58; 95% CI, 0.41–0.82 for oropharynx/hypopharynx; and OR, 0.61; 95% CI, 0.37–1.01 for oral cavity/pharynx not otherwise specified) and across strata of selected covariates. No association of caffeinated coffee drinking was found with laryngeal cancer (OR, 0.96; 95% CI, 0.64–1.45 in drinkers of &gt;4 cups per day versus nondrinkers). Data on decaffeinated coffee were too sparse for detailed analysis, but indicated no increased risk. Tea intake was not associated with head and neck cancer risk (OR, 0.99; 95% CI, 0.89–1.11 for drinkers versus nondrinkers).
Conclusions: This pooled analysis of case-control studies supports the hypothesis of an inverse association between caffeinated coffee drinking and risk of cancer of the oral cavity and pharynx.
Impact: Given widespread use of coffee and the relatively high incidence and low survival of head and neck cancers, the observed inverse association may have appreciable public health relevance. Cancer Epidemiol Biomarkers Prev; 19(7); 1723–36. ©2010 AACR.
Risk of Genome-Wide Association Study–Identified Genetic Variants for Colorectal Cancer in a Chinese Population
Authors: Xiong Fang , Wu Chen , Bi Xinyu , Yu Dianke , Huang Liming , Xu Jian , Zhang Tongwen , Zhai Kan , Chang Jiang , Tan Wen , Cai Jianqiang , Lin Dongxin 
Published: July 2010

AbstractBackground: Recent genome-wide association studies have identified 10 single nucleotide polymorphisms (SNP) associated with colorectal cancer (CRC) in Caucasians. This study evaluated the effects of these newly identified SNPs in a Chinese population.Methods: We assessed the associations of these 10 SNPs with CRC in a case-control study that consisted of 2,124 cases and 2,124 controls. Odds ratios (OR) and 95% confidence intervals were computed by logistic regression, and cumulative effect of risk genotypes were also calculated.Results: We found that only five SNPs (rs6983267, rs4939827, rs10795668, rs3802842, and rs961253) were significantly associated with risk of CRC in our study population in the same direction as reported by previous genome-wide association studies, with the ORs ranging from 1.11 to 2.96. A cumulative effect was observed with the ORs being gradually elevated with increasing number of risk genotypes (Ptrend = 1.32 × 10−21), and patients carrying ≥4 risk genotypes had 3.25-fold increased CRC risk (95% confidence interval, 2.24-4.72) compared with patients carrying no risk genotype. Furthermore, we found that rs10795668 was associated with increased risk only in rectal cancer but not colon cancer, and rs3802842 was also significantly associated with advanced stages of CRC.Conclusions: These results suggest that rs6983267, rs4939827, rs10795668, rs3802842, and rs961253 SNPs are associated with the risk of CRC in the Chinese population individually and jointly.Impact: Our results provide new insights into colorectal tumorigenesis and have potential implications in early detection and target treatment of CRC in non-Western populations. Cancer Epidemiol Biomarkers Prev; 19(7); 1855–61. ©2010 AACR.
Metabolic Syndrome and Breast Cancer in the Me-Can (Metabolic Syndrome and Cancer) Project
Authors: Bjørge Tone , Lukanova Annekatrin , Jonsson Håkan , Tretli Steinar , Ulmer Hanno , Manjer Jonas , Stocks Tanja , Selmer Randi , Nagel Gabriele , Almquist Martin , Concin Hans , Hallmans Göran , Häggström Christel , Stattin Pär , Engeland Anders 
Published: July 2010

Abstract
Background: Few studies have assessed the metabolic syndrome (MetS) as an entity in relation to breast cancer risk, and results have been inconsistent. We aimed to examine the association between MetS factors (individually and combined) and risk of breast cancer incidence and mortality.
Methods: Two hundred ninety thousand women from Austria, Norway, and Sweden were enrolled during 1974-2005, with measurements of height, weight, blood pressure, and levels of glucose, cholesterol, and triglycerides. Relative risks (RR) of breast cancer were estimated using Cox proportional hazards regression for each MetS factor in quintiles and for standardized levels (z-scores) and for a composite z-score for the MetS.
Results: There were 4,862 incident cases of breast cancer and 633 deaths from breast cancer identified. In women below age 50, there was a decreased risk of incident cancer for the MetS (per 1-unit increment of z-score; RR, 0.83; 95% confidence interval, 0.76-0.90) as well as for the individual factors (except for glucose). The lowest risks were seen among the heaviest women. In women above age 60, there was an increased risk of breast cancer mortality for the MetS (RR, 1.23; 95% confidence interval, 1.04-1.45) and for blood pressure and glucose. The strongest association with mortality was seen for increased glucose concentrations.
Conclusions: The MetS was associated with a decreased risk of incident breast cancer in women below age 50 with high body mass index, and with an increased risk of breast cancer mortality in women above 60.
Impact: Lifestyle interventions as recommended for cardiovascular disease prevention may be of value to prevent breast cancer mortality in postmenopausal women. Cancer Epidemiol Biomarkers Prev; 19(7); 1737–45. ©2010 AACR.
Well-Done Meat Consumption, NAT1 and NAT2 Acetylator Genotypes and Prostate Cancer Risk: The Multiethnic Cohort study
Authors: Sharma Sangita , Cao Xia , Wilkens Lynne R. , Yamamoto Jennifer , Lum-Jones Annette , Henderson Brian E. , Kolonel Laurence N. , Le Marchand Loïc 
Published: July 2010

Abstract
Background: Prostate cancer (PC) is the most common male malignancy in the United States and disparities in risk exist among ethnic/racial groups. A high intake of well-done meat and the presence of the rapid NAT1 and slow NAT2 acetylator genotypes, as modifiers of the carcinogenic effect of heterocyclic amines, were hypothesized to increase PC risk and possibly explain these ethnic differences in risk.
Methods: This study examined the associations between well-done (red) meat consumption, NAT1 and NAT2 acetylator genotypes, and PC risk among five ethnicities (African American, Native Hawaiian, Japanese American, Latino, and Caucasian) in a case-control study of PC nested within the Multiethnic Cohort study. Cases (n = 2,106) and controls (n = 2,063) were genotyped for eight single nucleotide polymorphisms in NAT1 and seven single nucleotide polymorphisms in NAT2 that characterized all common alleles for these genes. Well-done meat intake was computed based on responses to a detailed food frequency questionnaire including a question on meat preference. Conditional logistic regression was used in the analysis.
Results: There was no evidence of an increased risk associated with preference for well-done meat, intake of well-done meat, and NAT1 or NAT2 genotypes (jointly or separately).
Conclusions: These results do not support the hypothesis that exposure to heterocyclic amines is associated with risk of PC. However, additional studies with more precise exposure measures are needed. Cancer Epidemiol Biomarkers Prev; 19(7); 1866–70. ©2010 AACR.
Nonmelanoma Skin Cancer and the Risk of Second Primary Cancers: a Systematic Review
Authors: Wheless Lee , Black Joshua , Alberg Anthony J. 
Published: July 2010

Abstract
Background: Based on empirical evidence, a personal history of nonmelanoma skin cancer (NMSC) has been hypothesized to be a risk factor for other cancers. Others hypothesize that NMSC may be a marker of high cutaneous vitamin D synthesis and therefore inversely associated with risk of other malignancies. To reconcile these divergent views, we carried out a systematic review to determine the association between NMSC and subsequent risk of other cancers.
Methods: Bibliographic databases were searched through March 2009. Studies were included if sufficient information was presented to estimate the risk of developing other cancers following NMSC. Studies were reviewed and data were abstracted independently in duplicate with disagreements resolved by consensus.
Results: Of the 21 included studies, 15 reported the association between NMSC and risk of all other cancers combined. NMSC was significantly associated with increased risk of another malignancy among cohort studies based on cancer registries [summary random-effects relative risk (SRR), 1.12; 95% confidence interval (CI), 1.07-1.17; n = 12 studies) and those with individual-level data (SRR, 1.49; 95% CI, 1.12-1.98; n = 3). In stratified analyses of registry studies, this association held true for both squamous (SRR, 1.17; 95% CI, 1.12-1.23; n = 7) and basal cell carcinoma (SRR, 1.09; 95% CI, 1.01-1.17; n = 7), and both men (SRR, 1.14; 95% CI, 1.09-1.20; n = 12) and women (SRR, 1.10; 95% CI, 1.04-1.15; n = 12).
Conclusions: Strong, consistent evidence indicates that a personal history of NMSC is associated with increased risk of developing other malignancies.
Impact: For unknown reasons, NMSC may be a risk factor for other cancers. Cancer Epidemiol Biomarkers Prev; 19(7); 1686–95. ©2010 AACR.
Timing of Menarche and First Birth in Relation to Risk of Breast Cancer in A-Bomb Survivors
Authors: McDougall Jean A. , Sakata Ritsu , Sugiyama Hiromi , Grant Eric , Davis Scott , Nishi Nobuo , Soda Midori , Shimizu Yukiko , Tatsukawa Yoshimi , Kasagi Fumiyoshi , Suyama Akihiko , Ross Phillip , Kopecky Kenneth J. , Li Christopher I. 
Published: July 2010

Abstract
Background: The length of the interval between age at menarche and age at first birth is positively associated with breast cancer risk. We examined the risk of breast cancer in atomic bomb survivors to investigate whether women exposed to radiation between menarche and first birth had a higher risk of radiogenic breast cancer than women exposed at the same age but outside this interval.
Methods: Women (n = 30,113) were classified into three reproductive status at the time of the bombings (ATB) categories (premenarche, between menarche and first birth, or after first birth). Poisson regression was used to test the primary hypothesis.
Results: When the background rate of breast cancer was taken to depend on city, age ATB, and attained age only, the radiation-related excess relative risk (ERR) varied significantly among the three categories (P = 0.049). However, after controlling for significant heterogeneity in the baseline risk of breast cancer between reproductive status ATB groups (P &lt; 0.001), no significant heterogeneity (P = 0.88) was observed in the ERR, with an ERR per Gy of 1.36 [95% confidence interval (CI), 0.54-2.75] for women exposed between menarche and first birth ATB, and 1.07 (95% CI, 0.22-3.62) and 1.53 (95% CI, 0.63-2.90) for those exposed premenarche or after first birth, respectively.
Conclusions: The radiation-associated risk of breast cancer does not vary significantly by reproductive status ATB.
Impact: It is possible that radiation exerts similar carcinogenic effects on the breast regardless of its stage of differentiation, or that the differences in radiosensitivity are too small to be detected in this cohort. Cancer Epidemiol Biomarkers Prev; 19(7); 1746–54. ©2010 AACR.
Genomic Alterations and Allelic Imbalances Are Strong Prognostic Predictors in Osteosarcoma
Authors: Smida Jan , Baumhoer Daniel , Rosemann Michael , Walch Axel , Bielack Stefan , Poremba Christopher , Remberger Klaus , Korsching Eberhard , Scheurlen Wolfram , Dierkes Christian , Burdach Stefan , Jundt Gernot , Atkinson Michael J. , Nathrath Michaela 
Published: July 2010

Abstract
Purpose: Osteosarcoma, the most common primary malignant tumor of the bone, is characterized by complex karyotypes with numerous structural and numerical alterations. Despite attempts to establish molecular prognostic markers at the time of diagnosis, the most accepted predictive factor remains the histologic evaluation of necrosis after neoadjuvant chemotherapy. The present approach was carried out to search for genome-wide recurrent loss of heterozygosity and copy number variations that could have prognostic and therapeutic impact for osteosarcoma patients.
Experimental Design: Pretherapeutic biopsy samples of 45 osteosarcoma patients were analyzed using Affymetrix 10K2 high-density single nucleotide polymorphism arrays. Numerical aberrations and allelic imbalances were correlated with the histologically assessed response to therapy and clinical follow-up.
Results: The most frequent genomic alterations included amplifications of chromosome 6p21 (15.6%), 8q24 (15.6%, harboring MYC), and 12q14 (11.1%, harboring CDK4), as well as loss of heterozygosity of 10q21.1 (44.4%). All these aberrations and the total degree of heterozygosity of each tumor were significantly associated with an adverse outcome of patients and were used to define a chromosomal alteration staging system with a superior predictive potential compared with the histologic regression grading.
Conclusions: Structural chromosomal alterations detected by single nucleotide polymorphism analysis provide a simple but robust parameter to anticipate response to chemotherapy. The proposed chromosomal alteration staging system might therefore help to better predict the clinical course of osteosarcoma patients at the time of initial diagnosis and to adapt neoadjuvant treatment in patients resistant to the current protocols. Clin Cancer Res; 16(16); 4256–67. ©2010 AACR.
Remote-Controlled Magnetic Pulmonary Vein Isolation Using a New Irrigated-Tip Catheter in Patients With Atrial Fibrillation
Authors: Chun K.R. Julian , Wissner Erik , Koektuerk Buelent , Konstantinidou Melanie , Schmidt Boris , Zerm Thomas , Metzner Andreas , Tilz Roland , Boczor Sigrid , Fuernkranz Alexander , Ouyang Feifan , Kuck Karl-Heinz 
Published: July 2010

Background—
Lack of an irrigated-tip magnetic catheter has limited the role of remote-controlled magnetic navigation (Niobe II, Stereotaxis) for catheter ablation of atrial fibrillation (AF).

Methods and Results—
A novel 3.5-mm-tip irrigated magnetic catheter (group 1, Thermocool Navistar RMT, Biosense Webster) was used for 3D left atrial reconstruction (CARTO RMT) and remote-controlled magnetic pulmonary vein isolation. A redesigned catheter was used in group 2. The primary end point was wide area circumferential pulmonary vein isolation confirmed by spiral catheter recording during ablation; secondary end points included procedural data, complications, and AF recurrence. Fifty-six consecutive patients [group 1: 28 patients, 22 males, age 64 (38 to 78) years, left atrium: 47 (34 to 52) mm; paroxysmal AF: n=21, persistent AF: n=7; group 2: 28 patients, 20 males, age 60 (24 to 78) years, left atrium: 40 (35 to 53) mm; paroxysmal AF: n=18, persistent AF: n=10] were included. The primary end point was achieved in a total of 52 of 56 (93%) patients. Median procedure duration was 315 (125 to 550) minutes (group 1: 370 [230 to 550] minutes; group 2: 243 [125 to 450] minutes). Median fluoroscopy exposure to the investigator was reduced by 31%. Tip charring in 17 of 28 (61%) and complications in 3 of 28 (11%) patients in group 1 resulted in a catheter redesign. Sinus rhythm was maintained by 35 of 50 (70%) patients during a median follow-up period of 545 (100 to 683) days.

Conclusions—
Remote-controlled magnetic AF ablation with real-time verification of pulmonary vein isolation is feasible with a comparable success rate to manual ablation. Safety improved after a redesign of the catheter.
Inpatient service providers’ perspectives on service user involvement in Norwegian community mental health centres
Authors: Storm Marianne , Hausken Kjell , Knudsen Knud 
Published: July 2010

Background: For two decades, mental health services in Norway have focused on service user involvement. Despite this, there is little knowledge about how inpatient mental health services have promoted user involvement. Aim: To examine service providers’ reports of service user involvement at the individual and departmental levels in Norwegian community mental health centres (CMHCs). Methods: One hundred and eighty six (186) inpatient service providers in five CMHCs filled out a questionnaire. Results: Confirmatory factor analysis showed that service provider perceptions and awareness of service user involvement can be measured by three subscales: organizational user involvement; patient collaboration; and assisted patient involvement. Little user involvement was reported at the departmental level. Providers more often reported user involvement at the individual level. Providers in two of the CMHCs reported a somewhat higher degree of departmental-level user involvement. There were no significant differences across gender, age, leader position, profession and job tenure, though evening/night shift workers reported a lesser degree of user involvement. Conclusion: The results suggest that user involvement at the departmental level needs to be addressed in future efforts to promote user involvement in CMHCs.
Transformational Process of Health Care Choice of Poor in Kerala
Authors: Rajagopal N. 
Published: July 2010

Choice of poor people towards the type of health care services (public or private) has not been much discussed. This is mainly because of the underlying assumption that their choice has always been restricted to public health care services. The inefficiency of the public health care system in India has created a vacuum among the poor people regarding their preference for health care. Their tendency to transform from accessing public to private health care services is discussed in this context. The study was conducted among the low-income urban households of Kerala. It was noted that there is a strong willingness among these categories to access private health care services. Efficiency of the health care services was pointed out as a major reason for this. However, issues such as the high cost of private health care services remain unresolved. An option to revamp the public health care system cannot materialise especially when the budget allocation for public health service has reduced considerably. In this context, a proposal for an integrated system, which would work on distributive and redistributive mechanisms is suggested.
Trib1 links the MEK1/ERK pathway in myeloid leukemogenesis
Authors: Yokoyama Takashi , Kanno Yohei , Yamazaki Yukari , Takahara Tomoko , Miyata Satoshi , Nakamura Takuro 
Published: July 2010

Abstract
Trib1 is a myeloid oncogene that cooperates with Hoxa9 and Meis1. Although the MAPK pathway and C/EBP transcription factors are known to interact with Trib proteins, the mechanisms by which Trib1 contributes to myeloid leukemogenesis remains to be clarified. Here we report that interaction between Trib1 and MEK1 is required for Trib1-induced leukemogenesis. The C-terminal ILLHPWF motif that is well conserved among Trib family proteins is required for MEK1 binding, enhancement of ERK phosphorylation, enhanced self-renewal activity of bone marrow cells and leukemogenic activity by Trib1. The motif is also important for Trib1-induced C/EBPα degradation though interaction between Trib1 and C/EBPα is not necessary. Inhibition of ERK phosphorylation suppressed Trib1-induced C/EBPα degradation, indicating an important role for Trib1/MEK1 interaction. These results suggest that Trib1 may be a key mediator between the RTK-MAPK pathway and the C/EBP transcription factor in myeloid leukemogenesis.