bluuebunny/crossref_metadata_2025_split huggingface dataset:
Self‐administered, subcutaneous alemtuzumab to treat residual disease in patients with chronic lymphocytic leukemia
Authors: Wierda William G. , Kipps Thomas J. , Keating Michael J. , Brown Jennifer R. , Gribben John G. , Browning Mary , Rassenti Laura Z. , Greaves Andrew W. , Neuberg Donna , O'Brien Susan M. ,   and the CLL Research Consortium
Published: August 2010

AbstractBACKGROUND:Alemtuzumab is highly effective at treating chronic lymphocytic leukemia (CLL) in bone marrow, which is the usual site of residual disease after fludarabine‐based treatment. Eliminating residual disease potentially is associated with longer remission and overall survival. The authors of this report evaluated the ability of subcutaneous alemtuzumab to treat residual disease.METHODS:Patients in partial remission (PR), nodular PR (nPR), or complete remission (CR) who had disease in bone marrow established by 2‐color flow cytometry analysis were enrolled and received alemtuzumab 30 mg subcutaneously 3 times weekly for 4 weeks, and patients had the option to self‐administer alemtuzumab. Responders were patients in PR who converted to an nPR or a CR, patients in nPR who converted to a CR, and patients in CR who had no evidence of disease on 2‐color flow cytometry analysis after treatment.RESULTS:There were 31 patients enrolled, of whom 29 were evaluable, and there were 23 responders (4 of 4 patients who achieved a CR, 8 of 9 patients who achieved an nPR, and 11 of 16 patients who achieved a PR. Nonresponders had significantly lower plasma alemtuzumab levels at the end of treatment. Furthermore, higher plasma alemtuzumab levels at the end of treatment were correlated with a longer response duration. Compared with the results from an historic group that received intravenous alemtuzumab for residual disease, there was a trend toward a higher response rate but a shorter response duration with subcutaneous alemtuzumab.CONCLUSIONS:The current results demonstrated that self‐administered, subcutaneous alemtuzumab was safe and active for residual disease and that plasma alemtuzumab levels and real‐time minimal residual disease evaluation are important endpoints to monitor in future alemtuzumab consolidation trials. Cancer 2011. © 2010 American Cancer Society.
A front‐line window of opportunity phase 2 study of sorafenib in patients with advanced nonsmall cell lung cancer
Authors: Dy Grace K. , Hillman Shauna L. , Rowland Kendrith M. , Molina Julian R. , Steen Preston D. , Wender Donald B. , Nair Suresh , Mandrekar Sumithra , Schild Steven E. , Adjei Alex A. 
Published: August 2010

AbstractBACKGROUND:The current study was conducted to assess the efficacy and toxicity of sorafenib as front‐line therapy in patients with stage IIIB (pleural effusion) or IV nonsmall cell lung cancer (NSCLC).METHODS:Patients received sorafenib 400 mg twice daily by mouth continuously, and were evaluated every 2 weeks during the first 8 weeks. Patients who manifested clinical progression during this period proceeded to receive standard of care. The primary endpoint was confirmed objective tumor response. A 2‐stage Fleming design was used such that if at most 1 confirmed partial response (PR) or complete response was observed in the first 20 patients (stage 1), the treatment would be considered ineffective, and further enrollment would be discontinued.RESULTS:Only 1 PR was observed in the first 20 patients. By the time of study closure, 5 additional patients who were already being screened for study inclusion were enrolled. Of the 25 patients (15 women, 10 men; 4 stage IIIB, 21 stage IV; median age, 67 years [range, 45‐85 years]), there were 3 (12%) PRs and 6 (24%) cases with stable disease observed. The median time‐to‐progression and progression‐free survival was 2.8 months. Seven (28%) patients remained progression‐free at 24 weeks. No grade 3 or higher hematologic adverse events were observed. Thirteen (52%) patients had a grade 3 nonhematologic adverse event, with fatigue (20%), diarrhea (8%), and dyspnea (8%) being the most common.CONCLUSIONS:Sorafenib is not effective as front‐line therapy in the general unselected NSCLC population. The window of opportunity design is feasible for estimating the activity of novel compounds. Cancer 2010. © 2010 American Cancer Society.
Expression of the stem cell marker CD133 in recurrent glioblastoma and its value for prognosis
Authors: Pallini Roberto , Ricci‐Vitiani Lucia , Montano Nicola , Mollinari Cristiana , Biffoni Mauro , Cenci Tonia , Pierconti Francesco , Martini Maurizio , De Maria Ruggero , Larocca Luigi Maria 
Published: August 2010

AbstractBACKGROUND:Experimental data suggest that glioblastoma cells expressing the stem cell marker CD133 play a major role in radiochemoresistance and tumor aggressiveness. To date, however, there is no clinical evidence that the fraction of CD133‐positive cells in glioblastoma that recurs after radiochemotherapy may be relevant for prognosis.METHODS:The authors used immunohistochemistry to assess CD133 expression in 37 paired glioblastoma samples, including 1 primary tumor sample and 1 recurrent tumor sample, after patients received adjuvant radiochemotherapy. To assess the actual composition of the CD133‐positive glioblastoma cell population, fluorescence‐associated cell sorting (FACS) analysis was used to sort CD133‐positive/CD45‐negative cells that were assayed for tumor‐specific chromosomal aberrations using interphase fluorescence in situ hybridization. To rule out endothelial precursor cells, CD133‐positive fractions also were assayed with anti‐CD34 by FACS.RESULTS:In recurrent glioblastomas, the percentage of CD133‐positive cells was increased by 4.6‐fold compared with the percentage in primary glioblastomas, although, in some tumors, it increased up to 10‐fold and 20‐fold. Unexpectedly, the increase in CD133 expression was associated significantly with longer survival after tumor recurrence. An analysis of tumor‐specific chromosomal aberrations and in vivo studies revealed that the CD133‐positive cell compartment of recurrent glioblastoma was composed of both cancer stem cells and nontumor neural stem cells. The latter cells represented from 20% to 60% of the CD133‐positive cell population, and their relative percentage favorably affected the survival of patients with recurrent glioblastoma. Endothelial CD133‐positive/CD34‐positive precursors did not contribute to the CD133‐positive cell population.CONCLUSIONS:The authors hypothesized that, similar to the phenomenon described in glioblastoma models, neural stem/progenitor cells that are recruited by the tumor from surrounding brain may exert an antitumorigenic effect. Cancer 2011. © 2010 American Cancer Society.
Outcome of therapy‐related acute promyelocytic leukemia with or without arsenic trioxide as a component of frontline therapy
Authors: Dayyani Farshid , Kantarjian Hagop , O'Brien Susan , Pierce Sherry , Jones Dan , Faderl Stefan , Garcia‐Manero Guillermo , Cortes Jorge , Ravandi Farhad 
Published: August 2010

AbstractBACKGROUND:Patients with therapy‐related acute promyelocytic leukemia (t‐APL) have been commonly exposed to topoisomerase inhibitors and may potentially benefit from induction regimens omitting anthracyclines.METHODS:Retrospective analysis of the outcomes of 29 patients with t‐APL who were either treated with arsenic trioxide (ATO) and all‐trans‐retinoic acid (ATRA) or with standard ATRA plus anthracycline‐based chemotherapy was performed.RESULTS:Prior therapy included chemotherapy alone, radiation alone, or a combination of the 2 in 19%, 33%, and 47% of patients, respectively. The combination of ATO and ATRA (n = 19) for induction resulted in a similar remission rate compared with ATRA plus chemotherapy (n = 10) (89% vs 70%; P = .35). The median overall survival for the patients treated with ATRA plus ATO was not reached compared with that for patients treated with ATRA plus chemotherapy (161 weeks; P = .79).CONCLUSIONS:In this cohort of t‐APL patients, outcomes with ATO and ATRA appeared to be comparable to anthracycline‐containing induction regimens. This combination may be preferable in t‐APL patients to avoid any risk of anthracycline‐induced toxicities. Cancer 2011. © 2010 American Cancer Society.
Detection of EGFR and KRAS mutations in fine‐needle aspirates stored on Whatman FTA cards
Authors: da Cunha Santos Gilda , Liu Ni , Tsao Ming‐Sound , Kamel‐Reid Suzanne , Chin Kayu , Geddie William R. 
Published: August 2010

AbstractBACKGROUND:The aims of this study were to compare the quality of DNA recovered from fine‐needle aspirates (FNAs) stored on Whatman FTA cards with that retrieved from corresponding cell blocks and to determine whether the DNA extracted from the cards is suitable for multiple mutation analyses.METHODS:FNAs collected from 18 resected lung tumors and cell suspensions from 4 lung cancer cell lines were placed on FTA Indicating Micro Cards and further processed to produce paired formalin‐fixed paraffin‐embedded (FFPE) cell blocks. Fragment analysis was used for the detection of EGFR exon 19 deletion, and direct sequencing for detection of EGFR exon 21 L858R mutation and exon 2 deletion of KRAS. Corresponding FFPE tissue sections from 2 resection specimens were also tested.RESULTS:Analyses were successful with all FNAs and lung cancer‐derived cell lines collected on cards. Polymerase chain reaction failed in 2 cell blocks. For FNAs collected on cards, 5 cases showed EGFR and 3 showed KRAS mutations. Eleven cases were wild type. With cell blocks, 4 cases were found to harbor KRAS and 4 harbored EGFR mutations. All lung cancer‐derived cell lines tested positive for their respective mutations, and there was complete agreement between card and cell block FNA samples for EGFR exon 21. For EGFR exon 19, 1 of 18 cases showed discordant results between the card and cell block, and for KRAS 1 of 17. The two resection specimens tested gave concordant results with the FTA card.CONCLUSIONS:Storage of cytologic material on FTA cards can maximize and simplify sample procurement for multiple mutational analyses with results similar to those from cell blocks. Cancer (Cancer Cytopathol) 2010. © 2010 American Cancer Society.
POGGI: generating puzzle instances for online games on grid infrastructures
Authors: Iosup Alexandru 
Published: August 2010

AbstractThe developers of Massively multiplayer online games (MMOGs) rely on attractive content such as logical challenges (puzzles) to entertain and generate revenue from millions of concurrent players. While a large part of the content is currently generated by hand, the exponentially increasing number of players and their new demand for player‐customized content have made manual content generation undesirable. Thus, in this work we investigate the problem of automated, player‐customized game content generation at MMOG scale; to make our investigation tractable, we focus on puzzle game content generation. In this context, we design POGGI, an architecture for generating player‐customized game content using on‐demand, grid resources. POGGI focuses on the large‐scale generation of puzzle instances that match well the solving ability of the players, and that lead to fresh playing experience. Using our reference implementation of POGGI, we show through experiments in a real resource pool of over 1600 nodes that POGGI can generate commercial‐quality content at MMOG scale. Copyright © 2010 John Wiley & Sons, Ltd.
Acceptance of pain, self‐compassion and psychopathology: Using the Chronic Pain Acceptance Questionnaire to identify patients' subgroups
Authors: Costa Joana , Pinto‐Gouveia José 
Published: August 2010

AbstractThe present study explores whether specific subgroups of patients could be identified based on Chronic Pain Acceptance Questionnaire scores. A battery of self‐report questionnaire was used to assess acceptance of pain, self‐compassion and psychopathology in 103 participants with chronic pain, from Portuguese health care units.K‐Means cluster were performed and the results supported three subgroups of patients (low acceptance subgroup; high acceptance subgroup; intermediate subgroup with activity engagement near to the mean and low willingness to pain).One‐way ANOVA's showed that the three subgroups identified differed significantly from each other on psychopathology and self‐compassion. Results indicated that the intermediate subgroup presented less depression and stress, compared with the low acceptance subgroup. In what concerns self‐compassion, the low acceptance subgroup reported higher self‐judgment, isolation and over identification, compared with the intermediate subgroup. These subgroups also differed from each other in common humanity and mindfulness. Implications and clinical utility of the results were discussed, suggesting the increase of willingness to pain as an important key in chronic pain interventions. Copyright © 2010 John Wiley & Sons, Ltd.Key Practitioner Message:• Findings suggest the buffer effect of activity engagement in chronic pain on psychopathology;• The expressive relation between activity engagement and self‐compassion in chronic pain;• The presence of an intermediate subgroup of patients suggests that the increase of willingness to pain may add unique benefits in the treatment of chronic pain.
The relationship between resilience and levels of anxiety, depression, and obsessive–compulsive symptoms in adolescents
Authors: Hjemdal Odin , Vogel Patrick A. , Solem Stian , Hagen Kristen , Stiles Tore C. 
Published: August 2010

AbstractObjective: Mental health problems affect approximately 20% of adolescents. Traditionally, the principal focus has been on vulnerability and risk factors and less on protective factors. The study, therefore, explores the relation between frequent psychiatric symptoms and resilience factors among older adolescents.Method: The Resilience Scale for Adolescents (READ) was completed by 307 Norwegian high school students (M = 16.4 years) along with the Depression Anxiety Stress Scales, and the Obsessive–Compulsive Inventory‐Revised.Results: Higher resilience scores predicted lower scores on levels of depression, anxiety, stress and obsessive–compulsive symptoms after controlling for age and gender.Conclusion: This study provides further evidence that it may be fruitful for clinicians and researchers to attend to resilience factors in relation to psychological symptoms among older adolescents. Copyright © 2010 John Wiley & Sons, Ltd.Key Practitioner Message:• Resilience is significantly related to psychological symptoms in older adolescents after controlling for age and gender.• Resilience factors are differently expressed by female and male youths, but overall resilience is equally distributed among the sexes.• Assessment of resilience factors may provide appropriate targets for interventions among youths.
Mood and anxiety symptom questionnaire anxiety items in an adult british clinical sample: One scale or two?
Authors: Bedford Alan , Lukic Goran , Allerhand Michael , Deary Ian J. 
Published: August 2010

AbstractIn seeking to establish British clinical normative data for the two anxiety scales (anxious symptoms and anxious arousal) of the Mood and Anxiety Symptom Questionnaire (MASQ), the responses of 237 British National Health Service outpatients were examined. Factor analyses (exploratory and confirmatory) failed to confirm the expected structure. Data were presented and discussed, considering the 28 anxiety item pool in terms of being either two highly correlated scales of somatic anxiety versus psychological anxiety, or as a single general anxiety scale. As neither of these outcomes accorded with the test constructors' assumptions, it was concluded that the MASQ is not a suitable measure for assessing the tripartite model of adverse mood states in British clinical samples. Copyright © 2010 John Wiley & Sons, Ltd.Key Practitioner Message:• Exploratory and confirmatory factor analyses failed to confirm the a priori MASQ anxiety items' structure.• Alternative explanations were of either a) two highly correlated scales of somatic anxiety and psychological anxiety or b) a single general anxiety scale.
High‐order sensitivity invariants
Authors: Izydorczyk Jacek , Chojcan Jan 
Published: August 2010

AbstractThe aim of the research reported in this paper is to extend the notion of invariant sensitivity sum, widely known for electrical networks, from first‐order sensitivities to high‐order sensitivities. The results are high‐order invariant sums of sensitivities of the first and the second kind, formulated for nonlinear lumped circuit, which consists of one‐port and two‐ports only. One‐ports are generalized resistances, capacitances, inductances, voltages, and current sources, whereas two‐ports are nonlinear generalizations of four types of controlled sources. It is observed that the invariant sums actually found for nonlinear lumped networks are generalizations of sums given earlier by authors for linear lumped networks. The article is illustrated by numerical sensitivity analysis of simple linear and nonlinear circuits. Copyright © 2010 John Wiley & Sons, Ltd.
A phenomenological spice model for magneto‐impedance sensors
Authors: De La Cruz Blas Carlos A. , Gómez‐Polo Cristina , Carlosena Alfonso , Olivera Jesús 
Published: August 2010

SUMMARYIn this paper a lumped circuit model of magneto‐impedance (MI) sensors that can be easily implemented in Spice‐like simulators is proposed. The model is based on the equivalent circuit of a Padé's approximation derived from the impedance relied on Bessel functions. Thus, the model can simulate the transient and frequency responses from DC to several megahertz for a fix external magnetic field. Besides, the model can predict the impedance changes of the sensors as a nonlinear function of an external magnetic field via behavioral sources. This allows simulating MI sensors using magnetic feedback for controlling their response to improve linearity and dynamic range. The model has been verified using Spice simulations together with measurement results from a discrete prototype for generating the pulse voltage source, a simple modulation‐type configuration, and a feedback structure. Copyright © 2010 John Wiley & Sons, Ltd.
Performance analysis and simulations of 32‐ary cyclic code‐shift keying
Authors: Kao Chi‐Han , Robertson Clark , Kragh Frank , Lin Kyle 
Published: August 2010

AbstractCyclic code‐shift keying (CCSK) is the baseband 32‐ary symbol modulation scheme used by the Joint Tactical Information Distribution System (JTIDS), the communication terminal for Link‐16. CCSK is not orthogonal and an analytic expression for the probability of symbol error for CCSK has thus far been elusive. In this paper, an analytic upper bound on the probability of symbol error of CCSK is derived for the 32‐chip CCSK starting sequence chosen for JTIDS. The analytically obtained probability of symbol error is compared with two different Monte Carlo simulations for additive white Gaussian noise. The results of both simulations match the analytic results very well and show that the analytic method yields a tight upper bound. A new 32‐chip CCSK starting sequence which has a smaller maximum off‐peak cross‐correlation value than the current JTIDS starting sequence is proposed and evaluated both analytically and by simulation. The results obtained for the new CCSK starting sequence compare favorably with the CCSK starting sequence chosen for JTIDS. Published in 2010 by John Wiley & Sons, Ltd.
Performance analysis of the unicasting mode in multi‐relay systems
Authors: Long Hang , Wei Meiying , Duan Ruchen , Zheng Kan , Wang Wenbo 
Published: August 2010

AbstractThe unicasting mode is a natural choice in multi‐relay systems to utilize the spatial potential of source and destination nodes. In the unicasting phase, the source node transmits different data streams to several relay nodes with the downlink multi‐user precoding; in the multi‐accessing phase, relay nodes transmit the received data streams to the destination node simultaneously. In this paper, the received signal‐to‐noise‐ratio (SNR) at the destination node of the unicasting mode is analyzed and derived, which can be calculated with two SNRs related to the two phases as an approximate harmonic mean function. Then, an approximate method for calculating the system ergodic capacity is presented. The inner products between singular vectors are approximately replaced by their expectations and distribution functions of singular values are derived. The numerical and simulation results demonstrate the efficiency of the analysis and the approximate method. Copyright © 2010 John Wiley & Sons, Ltd.
A study of forward error correction for mobile multicast
Authors: Alexiou Antonios , Bouras Christos , Papazois Andreas 
Published: August 2010

Abstract3rd Generation Partnership Project (3GPP) has standardized the use of forward error correction (FEC) for the provision of reliable data transmission in the mobile multicast framework. This error control method inevitably adds a constant overhead in the transmitted data. However, it is so simple as to meet a prime objective for mobile multicast services; that is scalability to applications with thousands of receivers. In this paper, we present a study on the impact of application layer FEC on mobile multicast transmissions. We examine whether it is beneficial or not, how the optimal code dimension varies based on network conditions, which parameters affect the optimal code selection, and how this can be done. Additionally, we focus on one of the most critical aspects in mobile multicast transmission, which is power control. The evaluation is performed with the aid of a novel scheme that incorporates the properties of an evolved mobile network, as they are specified by the 3GPP. Copyright © 2010 John Wiley & Sons, Ltd.
Spatial expectations of young human infants, following passive movement
Authors: Kaufman Jordy , Needham Amy 
Published: August 2010

AbstractThree experiments are described that investigate 4.5‐month‐old infants' spatial thinking during passive movement using a task that required no manual or visual search. In these experiments, infants habituated to a display located near one corner of a table. Before the test trial the infants were either moved to the opposite side of the table or they remained in the same position that they held during the habituation trials. Also, between the habituation trials and the test trial, the display was either surreptitiously moved to the diagonally opposite position on the table, or the display remained stationary. The results showed that infants generally dishabituated when the actual (allocentric/objective) location of the display was changed between habituation and test. However, in Experiment 3, in which infants had reduced experience moving around the testing chamber, infants dishabituated to a change in their egocentric spatial relationship to the display. The results of this experiment suggest that experience moving around the testing chamber was a prerequisite for such location constancy. Taken together, the findings presented here indicate that with enough experience, young infants become aware of key spatial relationships in their environment during passive movement. © 2010 Wiley Periodicals, Inc. Dev Psychobiol 53: 23–36, 2011.