bluuebunny/crossref_metadata_2025_split huggingface dataset:
Anthracnose and bean common mosaic necrosis virus resistance in wild and landrace Phaseolus vulgaris (L.) genetic stocks
Authors: Awale Halima E. , Wiersma Andrew T. , Wright Evan M. , Buell C. Robin , Kelly James D. , Cichy Karen A. , Haus Miranda J. 
Published: May 2024

AbstractWild crop germplasm and landrace varieties have long been considered as a source of novel genetic variation for improving domesticated crops. Due to genetic bottlenecks that occurred during domestication, dissemination, and subsequent crop improvement, many beneficial genes are absent from commercial varieties and elite breeding germplasm, yet are still present in wild populations. To catalog potential novel disease resistance genes useful for breeding more resilient dry beans, we screened wild and landrace Phaseolus vulgaris L. accessions archived in the USDA GRIN seed bank for untapped resistance to anthracnose (Colletotrichum lindemuthianum) and bean common mosaic necrosis virus (BCMNV). A population of 194 wild and 55 landrace accessions were screened for resistance to two highly virulent races of anthracnose (race 2047 and race 3481) and for resistance to the BCMNV strain NL‐3. Thirteen accessions, all wild, were resistant to both anthracnose races, with MX‐QT‐3 and PI 661812 displaying complete resistance with no disease symptoms across all replications. Surprisingly, no natural resistance to BCMNV strain NL‐3 was detected in the wild germplasm. PI 442541, PI 661891, and W6 10164 were the only three accessions that expressed the I‐gene phenotype and all three have some history of cultivation. This study provides a resource for introgression of genetic diversity for anthracnose resistance into cultivated beans and reveals that innate resistance to BCMNV may not exist in wild populations of P. vulgaris.
Reaction Center Shifting in Partially Fluorinated Electrolytes for Robust Lithium Metal Battery
Authors: Yang Tong , Zhang Wenna , Shen Chunli , Ren Long , Liao Xiaobin , Guo Yaqing , Zhao Yan 
Published: May 2024

AbstractThe strategic formulation of a compatible electrolyte plays a pivotal role in extending the longevity of lithium‐metal batteries (LMBs). Here, we present findings on a partially fluorinated electrolyte distinguished by a subdued solvation affinity towards Li+ ions and a concentrated anion presence within the primary solvation layer. This distinctive solvation arrangement redirects the focal points of reactions from solvent molecules to anions, facilitating the predominant involvement of anions in the creation of a LiF‐enriched solid‐electrolyte interphase (SEI). Electrochemical assessments showcase effective Li+ transport kinetics, diminished overpotential polarization for Li nucleation (28 mV), and prolonged cycling durability in Li||Li cells employing the partially fluorinated electrolyte. When tested in Li||NCM811 cells, the designed electrolyte delivers a capacity retention of 89.30 % and exhibits a high average Coulombic efficiency of 99.80 % over 100 cycles with a charge‐potential cut‐off of 4.6 V vs. Li/Li+ under the current density of 0.4C. Furthermore, even at a current density of 1C, the cells maintain 81.90 % capacity retention and a high average Coulombic efficiency of 99.40 % after 180 cycles. This work underscores the significance of weak‐solvation interaction in partially fluorinated electrolytes and highlights the crucial role of solvent structure in enabling the long‐term stability and high‐energy density of LMBs.
Campylotropis xinfeniae (Fabaceae, Papilionoideae), a new species from Yunnan, China, based on morphological and molecular evidence
Authors: Jiang Li‐Sha , Li Xin‐Hui , Li Xiong , Xu Bo 
Published: May 2024

AbstractCampylotropis xinfeniae, a new species from the dry‐hot valley of the Jinsha River in the Yunnan province, China, is described and illustrated. It is morphologically similar to C. wilsonii and C. brevifolia in having glabrescent old branches, absent stipels, 3‐foliolate leaves, and adaxially puberulent leaflets, while it differs from the latter two in having often paniculate inflorescences, obviously white standard, not incurved sickle keel, larger narrowly oblique legumes, and longer legume beak. The complete chloroplast genome of this new species is 149,073 bp in length and exhibits a typical quadripartite structure. Phylogenetic analyses based on the complete chloroplast genome also supported C. xinfeniae as a new species located at the basal distinct clade of the genus Campylotropis, clearly separated from the remaining members of the genus and its allied genera. A conservation assessment of data deficient (DD) is recommended for the new species without extensive exploring of similar habitats according to the IUCN Categories and Criteria.
Cu‐Catalyzed Synthesis of [1,2,3]triazolo[1,5‐c]quinazolin‐5(6H)‐one Derivatives via Sequential Reaction of Ethyl‐2‐(2‐oxoindolin‐3‐ylidene)acetate with Sodium Azide
Authors: Ghosh Somnath , Mohanta Nirmala , Gnanaprakasam Boopathy 
Published: May 2024

AbstractHerein, we report a novel and efficient method for the synthesis of new class of 5‐oxo‐5,6‐dihydro‐[1,2,3]triazolo[1,5‐c]quinazoline derivatives by copper‐catalyzed reaction of α, β‐unsaturated keto/ester methyleneindolinone with sodium azide at room temperature via an azide‐alkene cyclization and ring expansion rearrangement. This method is applicable to a variety of α, β‐unsaturated keto/ester methyleneindolinone and displayed wide functional group tolerance.
Deep learning‐based seizure prediction using EEG signals: A comparative analysis of classification methods on the CHB‐MIT dataset
Authors: Esmaeilpour Ali , Tabarestani Shaghayegh Shahiri , Niazi Alireza 
Published: May 2024

AbstractEpilepsy is a brain disorder that causes patients to have multiple seizures. About 30% of patients with epilepsy are not treated with medication or surgery. The abnormal activity of brain before occurring of a seizure (about a few minutes before a seizure occurs) are known as the preictal area. Therefore, if we can predict this state, we can control possible seizures by using appropriate medications. In this study, we present a method for predicting epileptic seizures using electroencephalogram (EEG) signals. The method can identify the preictal region that occurs before the onset of seizures. In our proposed method, first the noise removal of EEG signals is performed, and then the necessary features are extracted using a convolution neural network. Finally, we use the feature vectors in order to train multiple classifiers, fully connected layer, random forest, and support vector machines with linear kernel. Additionally, we apply maximum voting, which is an ensemble method, to classify preictal segments from interictal ones. In this study, using EEG signals of patients from CHB‐MIT dataset, we were able to achieve sensitivity of 90.76%.
Enhanced removing of cyanobacterium by NZVI coupled with H2O2: Influencing factors and removal mechanisms
Authors: Ji Lipeng , Lu Hao , Wang Yue , Chu Fuhao , Wang Danni , Li Jiake , Mo Shuhong , Kong Yun 
Published: May 2024

AbstractAs advanced oxidation processes (AOPs) is considered to be a highly effective approach for degrading organic pollutants, the simultaneous coagulation and oxidation process by the Fenton‐like reaction of nanoscale zero‐valent iron (NZVI) and hydrogen peroxide (H2O2) is investigated to eliminate the harmful cyanobacterium Microcystis aeruginosa in this study, and the process conditions are optimized using the central composite design of response surface methodology (RSM); in addition, the removal efficiency of M. aeruginosa (in terms of chlorophyll a, Chl a) and the verifications of the antioxidant abilities, as well as extracellular organic matters (EOM) and intracellular organic matters (IOM) are investigated under the optimized conditions. Results indicate that H2O2 concentration is the key factor affecting the Chl a removal efficiency, and the maximum Chl a removal reaches 98.10% under the optimized conditions: NZVI concentration 62.82 mg L−1, H2O2 concentration 54.2 mmol L−1, pH 4.38 and rotating speed 67 rpm. The high correlation coefficient (R2 > 0.80) of analysis of variance (ANOVA) demonstrates the RSM model is extremely significant and suitable for experimental results. Moreover, the total organic carbon (TOC) and fluorescent substances (soluble cyanobacteria metabolic byproducts, aromatic proteins II, humic and fulvic acid‐like compounds) for both EOM and IOM are enhanced removal. It is speculated the removal mechanisms of the Fenton‐like process of NZVI/H2O2 for cyanobacterium belongs to the combined actions of the oxidation of Fe(II)/H2O2 and the coagulation of Fe(III), which destroy the defense system and result in the removal of M. aeruginosa.
Drosophila models of the anti‐inflammatory and anti‐obesity mechanisms of kombucha tea produced by Camellia sinensis leaf fermentation
Authors: Tran Duy Binh , Le Nguyen Khoi Nguyen , Duong Minh Tue , Yuna Kamo , Pham L. A. Tuan , Nguyen Q. C. Thanh , Tragoolpua Yingmanee , Kaewkod Thida , Kamei Kaeko 
Published: May 2024

AbstractKombucha tea is a traditional beverage originating from China and has recently gained popularity worldwide. Kombucha tea is produced by the fermentation of tea leaves and is characterized by its beneficial properties and varied chemical content produced during the fermentation process, which includes organic acids, amino acids, vitamins, minerals, and other biologically active compounds. Kombucha tea is often consumed as a health drink to combat obesity and inflammation; however, the bioactive effects of kombucha tea have not been thoroughly researched. In this study, we reveal the underlying mechanisms of the beneficial properties of kombucha tea and how they protect against obesity and inflammation by studying Drosophila models. We established an inflammatory Drosophila model by knocking down the lipid storage droplet‐1 gene, a human perilipin‐1 ortholog. In this model, dysfunction of lipid storage droplet‐1 induces inflammation by enhancing the infiltration of hemocytes into adipose tissues, increasing reactive oxygen species production, elevating levels of proinflammatory cytokines, and promoting the differentiation of hemocytes into macrophages. These processes are regulated by the c‐Jun N‐terminal Kinase (JNK) pathway. Using this unique Drosophila model that mimics mammalian inflammation, we verified the beneficial effects of kombucha tea on reducing tissue inflammation. Our data confirms that kombucha tea effectively improves inflammatory conditions by suppressing the expression of cytokines and proinflammatory responses induced by lipid storage droplet‐1 dysfunction. It was found that kombucha tea consumption alleviated the production of reactive oxygen species and activated the JNK signaling pathway, signifying its potential as an anti‐inflammatory agent against systemic inflammatory responses connected to the JNK pathway. Kombucha tea reduced triglyceride accumulation by increasing the activity of Brummer (a lipase), thereby promoting lipolysis in third‐instar larvae. Therefore, kombucha tea could be developed as a novel, functional beverage to protect against obesity and inflammation. Our study also highlights the potential use of this innovative model to evaluate the effects of bioactive compounds derived from natural products.
Managing risk and reaping rewards: Climate‐change futures as a game‐changer for energy futures markets
Authors: Hoque Mohammad Enamul , Kabir Hassan M. , Pezzo Luca 
Published: May 2024

AbstractClimate‐change futures provide a platform for low‐carbon portfolios and energy market risk hedging. Climate changes induce uncertainty in energy‐commodity markets. We investigate the potential of diversifying and hedging energy‐commodity market risk with climate‐change futures, using dynamic conditional correlation (DCC)‐ordinary least squares (OLS) incorporating quantile‐dummies and cross‐quantilogram (CQ) approaches. DCC‐OLS models reveal that the World and USA climate‐change futures exhibit that they can be diversifiers for oil, ethanol, gasoil, and gasoline. These futures also exhibit hedging features for natural gas, coal, and heating oil. Euro climate‐change futures demonstrate hedging capabilities for all energy commodities except oil and gasoil. World, USA, and Euro climate‐change futures have the potential to serve as safe‐haven financial instruments in the face of the high volatility of Brent crude oil, gasoil, and heating oil. The CQ reveals that World, USA, and Euro climate‐change futures exhibit hedging and safe‐haven capacity against oil, natural gas, coal, gasoil, gasoline, and heating futures. Climate‐change futures may protect financial investments during extreme volatility in energy commodities.
Suicidal behavior and all‐cause mortality in depressed older adults aged 75+ treated with electroconvulsive therapy: A Swedish register‐based comparison study
Authors: Hedna Khedidja , Jonson Mattias , Sigström Robert , Levinsson Anna , Nordenskjöld Axel , Waern Margda 
Published: May 2024

AbstractObjectivesElectroconvulsive therapy (ECT) is effective in treating late‐life depression. There is limited research on suicidal behavior and all‐cause mortality in the oldest old after ECT.MethodsOlder adults aged 75 years and above who had been inpatients for moderate to severe depression between January 1, 2011, and December 31, 2017, were included in the study. We used exact and propensity score matching to balance groups. We compared suicidal behavior (fatal and non‐fatal) and all‐cause mortality in those who had received ECT and those with other depression treatments.ResultsOf the study population, 1802 persons who received ECT were matched to 4457 persons with other treatments. There were no significant differences in the risk of suicidal behavior between groups, (within 3 months: odds ratio 0.73; 95% confidence intervals (CI), 0.44–1.23, within 4 months to 1 year: aOR 1.34; 95% CI, 0.84–2.13). All‐cause mortality was lower among ECT recipients compared to those who had received other treatments, both within 3 months (aOR, 0.35; 95% CI, 0.23–0.52), and within 4 months to 1 year (aOR 0.65; 95% CI, 0.50–0.83).ConclusionsCompared to other depression treatments, ECT is not associated with a higher risk of suicidal behavior in patients aged 75 and above. ECT is associated with lower all‐cause mortality in this age group, but we advise caution regarding causal inferences.
‘Black Out Rage Gallon’ (aka borg): An investigation of a risky drinking trend on TikTok
Authors: Mandzufas Joelie , Lim Natalie , McPhie Skye , Martin Craig , Johnston Robyn S. , Lombardi Karen , Trapp Gina S. A. 
Published: May 2024

AbstractIssue AddressedA ‘Black Out Rage Gallon’ (borg) is a customised, individual alcoholic beverage popularised on TikTok, whereby half the water in a gallon jug is replaced with alcohol (usually spirits), flavourings, electrolytes and caffeine. We investigated the characteristics and portrayal of the emerging alcohol trend associated with the hashtag descriptor #borg on TikTok.MethodsWe identified highly viewed TikTok videos with the #borg hashtag (n = 103) and conducted a content analysis, capturing viewer engagement (‘likes’, shares, comments), techniques used, characteristics of featured individuals, and the portrayal of alcohol and risky drinking behaviours.ResultsAlcohol was visible in three quarters of the videos analysed (n = 78, average amount of alcohol present 865 mL per borg) and consumed in one third of the videos (n = 34). One quarter of videos (n = 25) promoted alleged benefits of borg consumption compared to other alcohol products or approaches to drinking, yet only nine videos included a warning about potential harms.ConclusionsThe borg trend on TikTok may encourage risky drinking, by portraying it in a style that younger viewers are likely to see as fun and entertaining.So What?We were able to gain a better understanding of how this potentially health harming activity is represented on a social media platform that is popular with young people. The speedy dissemination of this trend highlights the need to monitor, investigate and counter emerging trends. Concurrently, there is an urgent need for content restrictions to limit the visibility and promotion of risky alcohol consumption on TikTok.
TTF1 control of LncRNA synthesis delineates a tumor suppressor pathway directly regulating the ribosomal RNA genes
Authors: Sibai Dany S. , Tremblay Michel G. , Lessard Frédéric , Tav Christophe , Sabourin‐Félix Marianne , Robinson Mark , Moss Tom 
Published: May 2024

AbstractThe tumor suppressor p14/19ARF regulates ribosomal RNA (rRNA) synthesis by controlling the nucleolar localization of Transcription Termination Factor 1 (TTF1). However, the role played by TTF1 in regulating the rRNA genes and in potentially controlling growth has remained unclear. We now show that TTF1 expression regulates cell growth by determining the cellular complement of ribosomes. Unexpectedly, it achieves this by acting as a “roadblock” to synthesis of the noncoding LncRNA and pRNA that we show are generated from the “Spacer Promoter” duplications present upstream of the 47S pre‐rRNA promoter on the mouse and human ribosomal RNA genes. Unexpectedly, the endogenous generation of these noncoding RNAs does not induce CpG methylation or gene silencing. Rather, it acts in cis to suppress 47S preinitiation complex formation and hence de novo pre‐rRNA synthesis by a mechanism reminiscent of promoter interference or occlusion. Taken together, our data delineate a pathway from p19ARF to cell growth suppression via the regulation of ribosome biogenesis by noncoding RNAs and validate a key cellular growth law in mammalian cells.
Ten different viral agents infecting and co‐infecting children with acute gastroenteritis in Southern Italy: Role of known pathogens and emerging viruses during and after COVID‐19 pandemic
Authors: Amoroso Maria Grazia , Pucciarelli Alessia , Serra Francesco , Ianiro Giovanni , Iafusco Michele , Fiorito Filomena , Polverino Maria Grazia , Dimatteo Maria , Monini Marina , Ferrara Daniela , Martemucci Luigi , Di Bartolo Ilaria , De Carlo Esterina , Fusco Giovanna 
Published: May 2024

AbstractAcute gastroenteritis (AGE) represents a world public health relevant problem especially in children. Enteric viruses are the pathogens mainly involved in the episodes of AGE, causing about 70.00% of the cases. Apart from well‐known rotavirus (RVA), adenovirus (AdV) and norovirus (NoV), there are various emerging viral pathogens potentially associated with AGE episodes. In this study, the presence of ten different enteric viruses was investigated in 152 fecal samples collected from children hospitalized for gastroenteritis. Real time PCR results showed that 49.3% of them were positive for viral detection with the following prevalence: norovirus GII 19.7%, AdV 15.8%, RVA 10.5%, human parechovirus (HPeV) 5.3%, enterovirus (EV) 3.3%, sapovirus (SaV) 2.6%. Salivirus (SalV), norovirus GI and astrovirus (AstV) 1.3% each, aichivirus (AiV) found in only one patient. In 38.2% of feces only one virus was detected, while co‐infections were identified in 11.8% of the cases. Among young patients, 105 were ≤5 years old and 56.0% tested positive for viral detection, while 47 were >5 years old with 40.0% of them infected. Results obtained confirm a complex plethora of viruses potentially implicated in gastroenteritis in children, with some of them previously known for other etiologies but detectable in fecal samples. Subsequent studies should investigate the role of these viruses in causing gastroenteritis and explore the possibility that other symptoms may be ascribed to multiple infections.
Infant formulas for the treatment of functional gastrointestinal disorders: A position paper of the ESPGHAN Nutrition Committee
Authors: Haiden Nadja , Savino Francesco , Hill Susan , Kivelä Laura , De Koning Barbara , Kӧglmeier Jutta , Luque Veronica , Moltu Sissel J. , Norsa Lorenzo , De Pipaon Miguel Saenz , Verduci Elvira , Bronsky Jiri 
Published: May 2024

AbstractFunctional gastrointestinal disorders (FGID), such as infant regurgitation, infant colic, and functional constipation, are common and typically physiological phenomena during the early months of an infant's life and account for frequent consultations with pediatricians. Various infant formulas are marketed for their management and are frequently given by parents to infants before a medical consultation. However, the evidence supporting their effectiveness is limited and some have altered nutritional compositions when compared to standard formulas. Thus, these products should only be used under medical supervision and upon medical advice. Marketing and over‐the‐counter sales do not ensure proper medical guidance and supervision. The aim of this position paper is to review the current evidence regarding the safety and efficacy of formulas specifically formulated for addressing regurgitation, colic, and constipation, recognized as FGID. The objective is to provide guidance for clinical management based on the highest quality of available evidence. A wide search using Pubmed, MEDLINE, EMBASE and Cochrane Database of Systematic Reviews was performed including the MESH terms infant formula, colic, constipation, regurgitation, reflux, palmitate, lactase, lactose, magnesium, hydrolyzed protein, prebiotics or probiotics. 752 papers were identified and screened. Finally, 72 papers were included in the paper. In the absence of evidence, recommendations reflect the authors' combined expert opinion. Final consensus was obtained by multiple e‐mail exchange and meetings of the Nutrition Committee. (1) For breastfed infants experiencing FGID such as regurgitation, colic, or constipation, transitioning from breastfeeding to commercial formulas is not recommended. (2) In general, whether an infant is breastfed or formula‐fed, it's crucial to reassure parents that FGIDs are normal and typically do not necessitate treatment or change to a special formula. (3) Thickened formulas, often termed anti‐reflux formulas, may be considered in specific cases of regurgitation. (4) The usage of specialized formulas for infants with colic is not advised due to a lack of clinical evidence. (5) In the case of constipation in infants, the use of formulas enriched with high β‐palmitate and increased magnesium content may be considered to soften the stool. Generally, there is limited evidence supporting the use of specialized formulas for FGID. Breastfeeding should never be discontinued in favor of formula feeding.
Acupuncture treatment for liver cancer pain: A meta‐analysis
Authors: He Yi , Xiang Shate , Zhang Danjun , Chen Muzhi 
Published: May 2024

AbstractAcupuncture treatment is a common intervention for the clinical relief of primary liver cancer (PLC) pain, but there is variability in its efficacy. This review systematically assessed the efficacy and safety of acupuncture treatment for PLC pain by meta‐analysis. A total of 17 randomized controlled trial studies involving 1162 patients met the inclusion criteria. This study identified the acupuncture method, treatment duration, and patient age were the main factors affecting the efficacy of acupuncture treatment.