bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pulmonary kinematics from tagged hyperpolarized helium‐3 MRI
Authors: Tustison Nicholas J. , Awate Suyash P. , Cai Jing , Altes Talissa A. , Miller G. Wilson , de Lange Eduard E. , Mugler John P. , Gee James C. 
Published: April 2010

AbstractPurpose:To propose and test the feasibility of a novel method for quantifying 3D regional pulmonary kinematics from hyperpolarized helium‐3 tagged MRI in human subjects using a tailored image processing pipeline and a recently developed nonrigid registration framework.Materials and Methods:Following image acquisition, inspiratory and expiratory tagged 3He magnetic resonance (MR) images were preprocessed using various image filtering techniques to enhance the tag surfaces. Segmentation of the three orthogonal sets of tag planes in each lung produced distinct point‐set representations of the tag surfaces. Using these labeled point‐sets, deformation fields and corresponding strain maps were obtained via nonrigid point‐set registration. Kinematic analysis was performed on three volunteers.Results:Tag lines in inspiratory and expiratory images were coregistered producing a continuous 3D correspondence mapping. Average displacement and directional strains were calculated in three subjects in the inferior, mid, and superior portions of the right and left lungs. As expected, the predominant direction of displacements with expiration is from inferior to superior.Conclusion:Kinematic quantitation of pulmonary motion using tagged 3He MRI is feasible using the applied image preprocessing filtering techniques and nonrigid point‐set registration. Potential benefits from regional pulmonary kinematic quantitation include the facilitation of diagnosis and local assessment of disease progression. J. Magn. Reson. Imaging 2010;31:1236–1241. © 2010 Wiley‐Liss, Inc.
Residual magnetism in an MRI suite after field‐rampdown: What are the issues and experiences?
Authors: Sammet Steffen , Koch Regina Maria , Aguila Francisco , Knopp Michael Vinzenz 
Published: April 2010

AbstractPurposeTo investigate residual magnetization at different locations in the MRI suite at several time points prior, during and after field‐rampdown with the goal to determine if the MRI suites could be reused in a clinical environment after the field‐rampdown of MR scanners of different field strengths.Materials and MethodsResidual magnetism was measured with two gaussmeters in the MRI suites of an 8 Tesla (T) and a 0.7T whole body magnet at several time points prior, during and after field‐rampdown.ResultsResidual magnetism, in the MRI suite after controlled rampdown of an 8T superconducting magnet, was not significantly elevated compared with magnetic fields in the environment. Through 40 days, no significant changes in magnetism could be seen compared with initial measurements directly after rampdown, as both gaussmeters consistently measured. Similar findings were also observed after the quenched shutdown of a 0.7T system but a remanence was observed.ConclusionA controlled rampdown of even an ultrahigh field MR system does not lead to retained magnetic contamination, while forced quenched rampdown of a mid‐field system revealed temporary remanence. There is no need to degauss an MRI suite when an appropriate steel composition has been used in the iron shield. J. Magn. Reson. Imaging 2010;31:1272–1276. © 2010 Wiley‐Liss, Inc.
Right coronary artery flow velocity and volume assessment with spiral K‐space sampled breathhold velocity‐encoded MRI at 3 tesla: Accuracy and reproducibility
Authors: Brandts Anne , Roes Stijntje D. , Doornbos Joost , Weiss Robert G. , de Roos Albert , Stuber Matthias , Westenberg Jos J.M. 
Published: April 2010

AbstractPurpose:To evaluate accuracy and reproducibility of flow velocity and volume measurements in a phantom and in human coronary arteries using breathhold velocity‐encoded (VE) MRI with spiral k‐space sampling at 3 Tesla.Materials and Methods:Flow velocity assessment was performed using VE MRI with spiral k‐space sampling. Accuracy of VE MRI was tested in vitro at five constant flow rates. Reproducibility was investigated in 19 healthy subjects (mean age 25.4 ± 1.2 years, 11 men) by repeated acquisition in the right coronary artery (RCA).Results:MRI‐measured flow rates correlated strongly with volumetric collection (Pearson correlation r = 0.99; P < 0.01). Due to limited sample resolution, VE MRI overestimated the flow rate by 47% on average when nonconstricted region‐of‐interest segmentation was used. Using constricted region‐of‐interest segmentation with lumen size equal to ground‐truth luminal size, less than 13% error in flow rate was found. In vivo RCA flow velocity assessment was successful in 82% of the applied studies. High interscan, intra‐ and inter‐observer agreement was found for almost all indices describing coronary flow velocity. Reproducibility for repeated acquisitions varied by less than 16% for peak velocity values and by less than 24% for flow volumes.Conclusion:3T breathhold VE MRI with spiral k‐space sampling enables accurate and reproducible assessment of RCA flow velocity. J. Magn. Reson. Imaging 2010;31:1215–1223. © 2010 Wiley‐Liss, Inc.
Reliability of in vivo determination of forearm muscle volume using 3.0 T magnetic resonance imaging
Authors: Smeulders M.J.C. , van den Berg S. , Oudeman J. , Nederveen A.J. , Kreulen M. , Maas M. 
Published: April 2010

AbstractPurpose:To apply magnetic resonance imaging (MRI) as a tool for quantifying muscle volume of forearm muscles feasibility and reliability of volume estimation of the flexor carpi ulnaris (FCU) and the extensor carpi ulnaris (ECU).Materials and Methods:Forearms of 10 subjects were scanned twice. Muscle volumes were calculated from manual outlines on axial slices, slice thickness, and the number of slices. Observer agreement and repeatability were estimated using intraclass correlation, coefficient of variation, and the smallest detectable difference.Results:The average volume of the FCU and ECU was 31.0 mL (SD 11.5 mL) and 16.4 mL (SD 7.7 mL), respectively. Intraclass correlation coefficients of the volumes were all above 0.99 and the coefficient of variation varied between 5.7% and 0.8%. The smallest detectable difference corresponded to ≈7% of muscle volume.Conclusion:MRI muscle volume measurement of forearm muscles is feasible, reproducible, and allows for longitudinal studies where expected responsiveness exceeds 7%. J. Magn. Reson. Imaging 2010;31:1252–1255. © 2010 Wiley‐Liss, Inc.
Magnetic resonance imaging of the elbow
Authors: Stevens Kathryn J. 
Published: April 2010

AbstractElbow pain is frequently encountered in clinical practice and can result in significant morbidity, particularly in athletes. Magnetic resonance imaging (MRI) is an excellent diagnostic imaging tool for the evaluation of soft tissue and osteochondral pathology around the elbow. Recent advances in magnetic field strength and coil design have lead to improved spatial resolution and superior soft tissue contrast, making it ideal for visualization of complex joint anatomy. This article describes the normal imaging appearances of anatomy around the elbow and reviews commonly occurring ligamentous, myotendinous, neural, and bursal pathology around the elbow. J. Magn. Reson. Imaging 2010;31:1036–1053. © 2010 Wiley‐Liss, Inc.
Comparison of physiological triggering schemes for diffusion‐weighted magnetic resonance imaging in kidneys
Authors: Binser Tobias , Thoeny Harriet C. , Eisenberger Ute , Stemmer Alto , Boesch Chris , Vermathen Peter 
Published: April 2010

AbstractPurpose:To determine the potential benefit of combined respiratory‐cardiac triggering for diffusion‐weighted imaging (DWI) of kidneys compared to respiratory triggering alone (RT).Materials and Methods:Renal DWI was performed in 17 volunteers comparing RT, combined respiratory‐cardiac triggering (RCT), and combined respiratory‐cardiac triggering with slice position correction (RCTF). Data were analyzed in three ways: A1) Model‐free analysis of the signal stability over repeated measurements; A2) Analysis of the deviation from diffusion‐model fitting comparing the root mean squared error (RMSE), assessing within‐subject variabilities; and A3) Analysis of diffusion indices comparing between‐subject variabilities.Results:Combined respiratory‐cardiac triggering yielded lower signal fluctuations and more reliable diffusion parameter estimation than respiratory triggering alone in all three analysis methods: A1) The mean coefficient of variation (CV) for all subjects was 4.2 ± 1.1% and 4.3 ± 0.9% for RCT and RCTF, respectively, which was significantly lower compared to RT (5.3 ± 0.9%, P < 0.005); A2) RT yielded significantly higher RMSEs than RCT and RCTF; A3) The between‐subject variations of diffusion indices tended toward higher values for RT. The results were independent of perfusion contributions to the DWI data. No difference was determined between RCT and RCTF. Total acquisition time was only slightly prolonged for respiratory‐cardiac double‐triggering.Conclusion:Respiratory‐cardiac double‐triggering seems advantageous for renal DWI. J. Magn. Reson. Imaging 2010; 31:1144–1150. © 2010 Wiley‐Liss, Inc.
Structural and mechanical parameters of trabecular bone estimated from in vivo high‐resolution magnetic resonance images at 3 tesla field strength
Authors: Wald Michael Jeffrey , Magland Jeremy Franklin , Rajapakse Chamith Sudesh , Wehrli Felix Werner 
Published: April 2010

AbstractPurpose:To evaluate the performance of a new 3 Tesla (T) high‐resolution trabecular bone (TB) imaging technique at two resolution regimens in terms of serial reproducibility and sensitivity.Materials and Methods:The left distal tibial metaphysis of seven healthy volunteers was imaged at three time‐points using a FLASE (fast large‐angle spin‐echo) pulse sequence at 137 × 137 × 410 μm3 and (160 μm)3 voxel sizes. Image artifacts, motion degradation, and serial image volume misalignments were controlled to maximize reproducibility of image‐derived measures of scale, topology, orientation in terms of structural anisotropy, and finite‐element derived Young's and shear moduli. Coefficients of variation (CV) and intraclass correlation coefficients (ICC) for structural and mechanical parameters were evaluated as measures of reproducibility and reliability. The ability of structural and mechanical parameters to distinguish between subjects was tested by analysis of variance.Results:Reproducibility was generally higher in the anisotropic data (CVs 1–5% versus 1–9% for isotropic images). Anisotropic voxel size yielded greater measurement reliability (ICCs 0.75–0.99, mean = 0.92 versus 0.62–0.99, mean = 0.86) and better discrimination of the seven subjects (75% versus 50% of the possible comparisons were significantly different [P < 0.05]) except for measures of structural anisotropy and topology. Isotropic resolution improved detection of structural orientation and permitted visualization of small perforations in longitudinal trabecular plates not detected at anisotropic resolution.Conclusion:Improved image acquisition and processing techniques enhance reproducibility of structural and mechanical parameters derived from high‐resolution MRI of metaphyseal bone in the distal tibia. J. Magn. Reson. Imaging 2010;31:1157–1168. © 2010 Wiley‐Liss, Inc.
In vivo MRI of altered proton signal intensity and T2 relaxation in a bleomycin model of pulmonary inflammation and fibrosis
Authors: Jacob Richard E. , Amidan Brett G. , Soelberg Jolen , Minard Kevin R. 
Published: April 2010

AbstractPurpose:To investigate the ability of proton (1H) magnetic resonance imaging (MRI) to distinguish between pulmonary inflammation and fibrosis.Materials and Methods:Three groups of Sprague‐Dawley rats (n = 5) were instilled intratracheally with bleomycin (2.5 U/kg or 3.5 U/kg) in saline or with saline only. Rats were imaged at 2.0 Tesla using a multi‐slice Carr‐Purcell‐Meilboom‐Gill (CPMG) sequence with 6 ms echo spacing. Signal intensity (S0) and T2 were calculated on a pixel‐by‐pixel basis using images collected before dosing and 1, 2, 4, and 7 weeks after. At each time point, data from dosed animals were compared with controls, and bivariate statistical analysis was used to classify image pixels containing abnormal tissue. At week 7, pulmonary function tests were performed, then all rats were killed, left lungs were formalin fixed and tri‐chrome stained for histological analysis of collagen content, and right lungs were used to measure water and hydroxyproline (collagen) content.Results:The product S0×T2 significantly correlated with water and collagen content in the high‐dose group (P = 0.004 and P = 0.03, respectively). However, S0 and T2 of abnormal tissue were correlated for all time points (r = 0.93, P < 0.001), and could not distinguish inflammation from fibrosis.Conclusion:MRI can be used to confidently localize pulmonary inflammation and fibrosis, but it lacks specificity. J. Magn. Reson. Imaging 2010;31:1091–1099. © 2010 Wiley‐Liss, Inc.
Pulmonary blast injury in mice: A novel model for studying blast injury in the laboratory using laser‐induced stress waves
Authors: Satoh Yasushi , Sato Shunichi , Saitoh Daizoh , Tokuno Shinichi , Hatano Ben , Shimokawaji Tadasuke , Kobayashi Hideo , Takishima Kunio 
Published: April 2010

AbstractBackground and ObjectivesPrimary blast injury is produced by shock waves. Blast injuries to lungs are extremely critical threats to survival, but their etiology is largely undefined. The majority of animal models for these injuries use explosive or complex experimental settings, limiting the laboratory study of blast injury. The aim of this study was to establish a small‐animal model for blast injuries, using laser‐induced stress waves (LISWs) with high controllability, high reproducibility, and easy experimental settings.Study Design/Materials and MethodsLISWs were used to produce isolated pulmonary blast effects in mice. An LISW was generated by the irradiation of an elastic laser target with 532‐nm nanosecond laser pulses of a Q‐switched Nd:YAG laser. Histopathological evaluations of damage to lung tissue were conducted to estimate the relevance between peak pressure and trauma intensity. Blood pressure, heart rate, and percutaneous oxygen saturation were monitored for 60 minutes.ResultsWe could flexibly control the peak pressure of the shock wave by varying the laser energy. Non‐lethal doses of LISWs caused pulmonary contusions with alveolar hemorrhages depending on peak pressure. Pulmonary contusion was observed only in areas that were exposed to LISWs, allowing study of isolated injuries without concomitant ones. These injuries caused decreased blood pressure, heart rate, and percutaneous oxygen saturation, immediately after LISW exposure.ConclusionMice exposed to thoracic LISWs showed pathologic and physiologic changes similar to those seen in other studies in this area, and in clinical practice. Our newly developed model allows fine management of trauma intensity, and concomitant injuries of the exposed animals were limited. This novel mouse model of blast injury using LISWs is suitable for detailed studies of blast lung contusion and other blast injuries in the laboratory. Lasers Surg. Med. 42:313–318, 2010. © 2010 Wiley‐Liss, Inc.
Preliminary investigation on use of high‐resolution optical coherence tomography to monitor injury and repair in the rat sciatic nerve
Authors: Chlebicki Cara A. , Lee Alice D. , Jung Woonggyu , Li Hongrui , Liaw Lih‐Huei , Chen Zhongping , Wong Brian J. 
Published: April 2010

AbstractBackground and ObjectiveOptical coherence tomography (OCT) has been used in limited settings to study peripheral nerve injury. The purpose of the study is to determine whether high‐resolution OCT can be used to monitor nerve injury and regeneration in the rat sciatic nerve following crush injury, ligation, and transection with microsurgical repair.Study Design/Materials and MethodsForty‐five rats were segregated into three groups. The right sciatic nerve was suture ligated (n = 15), cut then microsurgically repaired (n = 15), or crushed (n = 15). The left sciatic nerve served as the control; only surgical exposure and skin closure were performed. Each group was further divided into three subgroups where they were assigned survival durations of 4, 15, or 24 weeks. Following euthanasia, nerves were harvested, fixed in formalin, and imaged at the injury site, as well as proximal and distal ends. The OCT system resolution was approximately 7 µm in tissue with a 1,060 nm central wavelength.ResultsControl (uninjured) nerve tissue showed homogenous signal distribution to a relatively uniform depth; in contrast, damaged nerves showed irregular signal distribution and intensity. Changes in signal distribution were most significant at the injury site and distal regions. Increases in signal irregularity were evident during longer recovery times. Histological analysis determined that OCT imaging was limited to the surrounding perineurium and scar tissue.ConclusionOCT has the potential to be a valuable tool for monitoring nerve injury and repair, and the changes that accompany wound healing, providing clinicians with a non‐invasive tool to treat nerve injuries. Lasers Surg. Med. 42:306–312, 2010. © 2010 Wiley‐Liss, Inc.
Clinical study to determine the safety and efficacy of a low‐energy, pulsed light device for home use hair removal
Authors: Elm Courtney M.L. , Wallander Irmina D. , Walgrave Susan E. , Zelickson Brian D. 
Published: April 2010

AbstractBackground and ObjectivesThe principle of selective photo‐thermolysis has been studied extensively for hair removal applications in a medical setting. A new, portable, hand‐held device featuring two filtered Xenon lamps that utilizes pulsed light in low optical fluencies for hair removal has been developed for consumer use. The purpose of this clinical study was to determine the efficacy and safety of this low‐energy, pulsed‐intense light device intended for home use hair removal.Study Design/ Materials and MethodsThe treatment group consisted of 10 adults with skin types I–IV who possessed unwanted dark hair in the non‐facial region. The subjects received between 4 and 6 treatments on a bi‐weekly basis with the device by a trained member of the clinical staff. The clinical responses were evaluated by performing manual hair counts using magnified vision and photographs which were obtained prior to treatment and at each subsequent visit.ResultsMean hair reduction was 36% 4 weeks after the final treatment and 10% 12 weeks after the final treatment. This resulted in a mean hair count reduction of 23% over the two follow‐up appointments. There was no definitive correlation between customer satisfaction and hair count reduction. Adverse reactions were limited to transient, localized, post‐treatment erythema. No complications were encountered.ConclusionsThis low‐energy, pulsed‐light device is a quick, safe, and relatively effective at‐home hair reduction treatment option in patients with various skin phototypes. Lasers Surg. Med. 42:287–291, 2010. © 2010 Wiley‐Liss, Inc.
Revising the Cannabis Use Disorders Identification Test (CUDIT) by means of Item Response Theory
Authors: Annaheim Beatrice , Scotto Thomas J. , Gmel Gerhard 
Published: April 2010

AbstractCannabis use among adolescents and young adults has become a major public health challenge. Several European countries are currently developing short screening instruments to identify ‘problematic’ forms of cannabis use in general population surveys. One such instrument is the Cannabis Use Disorders Identification Test (CUDIT), a 10‐item questionnaire based on the Alcohol Use Disorders Identification Test. Previous research found that some CUDIT items did not perform well psychometrically. In the interests of improving the psychometric properties of the CUDIT, this study replaces the poorly performing items with new items that specifically address cannabis use.Analyses are based on a sub‐sample of 558 recent cannabis users from a representative population sample of 5722 individuals (aged 13–32) who were surveyed in the 2007 Swiss Cannabis Monitoring Study. Four new items were added to the original CUDIT. Psychometric properties of all 14 items, as well as the dimensionality of the supplemented CUDIT were then examined using Item Response Theory.Results indicate the unidimensionality of CUDIT and an improvement in its psychometric performance when three original items (usual hours being stoned; injuries; guilt) are replaced by new ones (motives for using cannabis; missing out leisure time activities; difficulties at work/school). However, improvements were limited to cannabis users with a high problem score. For epidemiological purposes, any further revision of CUDIT should therefore include a greater number of ‘easier’ items. Copyright © 2010 John Wiley & Sons, Ltd.
T1ρ MRI quantification of arthroscopically confirmed cartilage degeneration
Authors: Witschey Walter R. T. , Borthakur Arijitt , Fenty Matt , Kneeland Bruce J. , Lonner Jess H. , McArdle Erin L. , Sochor Matt , Reddy Ravinder 
Published: April 2010

AbstractNine asymptomatic subjects and six patients underwent T1ρ MRI to determine whether Outerbridge grade 1 or 2 cartilage degeneration observed during arthroscopy could be detected noninvasively. MRI was performed 2‐3 months postarthroscopy, using sagittal T1‐weighted and axial and coronal T1ρ MRI, from which spatial T1ρ relaxation maps were calculated from segmented T1‐weighted images. Median T1ρ relaxation times of patients with arthroscopically documented cartilage degeneration and asymptomatic subjects were significantly different (P < 0.001), and median T1ρ exceeded asymptomatic articular cartilage median T1ρ by 2.5 to 9.2 ms. In eight observations of mild cartilage degeneration at arthroscopy (Outerbridge grades 1 and 2), mean compartment T1ρ was elevated in five, but in all observations, large foci of increased T1ρ were observed. It was determined that T1ρ could detect some, but not all, Outerbridge grade 1 and 2 cartilage degeneration but that a larger patient population is needed to determine the sensitivity to these changes. Magn Reson Med 63:1376–1382, 2010. © 2010 Wiley‐Liss, Inc.
Separate MRI quantification of dispersed (ferritin‐like) and aggregated (hemosiderin‐like) storage iron
Authors: Jensen Jens H. , Tang Haiying , Tosti Christina L. , Swaminathan Srirama V. , Nunez Alvaro , Hultman Kristi , Szulc Kamila U. , Wu Ed X. , Kim Daniel , Sheth Sujit , Brown Truman R. , Brittenham Gary M. 
Published: April 2010

AbstractA new MRI method is proposed for separately quantifying the two principal forms of tissue storage (nonheme) iron: ferritin iron, a dispersed, soluble fraction that can be rapidly mobilized, and hemosiderin iron, an aggregated, insoluble fraction that serves as a long‐term reserve. The method utilizes multiple spin echo sequences, exploiting the fact that aggregated iron can induce nonmonoexponential signal decay for multiple spin echo sequences. The method is validated in vitro for agarose phantoms, simulating dispersed iron with manganese chloride, and aggregated iron with iron oxide microspheres. To demonstrate feasibility for human studies, preliminary in vivo data from two healthy controls and six patients with transfusional iron overload are presented. For both phantoms and human subjects, conventional R2 and R2* relaxation rates are also measured in order to contrast the proposed method with established MRI iron quantification techniques. Quantification of dispersed (ferritin‐like) iron may provide a new means of monitoring the risk of iron‐induced toxicity in patients with iron overload and, together with quantification of aggregated (hemosiderin‐like) iron, improve the accuracy of estimates for total storage iron. Magn Reson Med 63:1201–1209, 2010. © 2010 Wiley‐Liss, Inc.