bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Therapeutic Potential of West Indian Lemongrass (Cymbopogon citratus) Essential Oil-Based Ointment in the Treatment of Pitted Keratolysis
Authors: Schneider György , Schweitzer Bettina , Steinbach Anita S. , Hodován Ágnes S. , Horváth Marianna , Bakó Eszter , Mayer Anna , Pál Szilárd 
Published: February 2025

Background: Due to their antibacterial activities, essential oils can be potential alternatives to antibiotics in certain cases. West Indian lemongrass (Cymbopogon citratus) essential oil (LEO) is effective against a broad range of bacteria by inhibiting spore formation, and is considered safe. In this study, we demonstrated its therapeutical potential in the treatment of pitted keratolysis (PK), a superficial skin infection affecting the pressure-bearing areas of plantar surfaces. Methods: For in vitro antibacterial efficacy testing, LEO was mixed into different ointment bases, including Hydrogelum methylcellulose FoNo VIII., Ungentum oleosum FoNo VIII. (Ung. oleoso), Unguentum stearini FoNo VIII. (Ung. stearin), and Vaselinum cholesterinatum FoNo VIII. (Vasel. cholest.), at different concentrations of 1, 3, and 5%. These formulations were tested on representatives of three bacterial species associated with PK: Kytococcus sedentarius, Dermatophilus congolensis, and Bacillus thuringiensis. Results: In the in vitro tests, Hydrogelum methylcellulose (HM) gel best supported the antibacterial effects of LEO, reducing the number of living bacteria on agar plates by 4–5 orders of magnitude in a concentration-dependent manner during the 30 min exposure times. This was also confirmed by the Franz diffusion cell drug release test; after 30 min, several active compounds could be detected in the HM samples, in contrast to the other bases. Shelf-life experiments showed that the HM base supported the antibacterial features of 3% LEO for at least 2 years without significant loss of efficacy. Conclusions: Our study highlights that ointments containing essential oils potentially have a place in the treatment of PK. Therefore, antibiotics may potentially be replaced for the treatment of PK, thereby reducing environmental antibiotic pressure, which is one of the driving forces behind the spread of antibiotic resistance.
Оценка эффективности вакцин против коклюша у взрослых: особенности иммунного ответа и значение ревакцинации (научное исследование, базирующееся на всестороннем, глубоком анализе данных современной литературы)
Authors: Батраханов А.Р. , Шахбанова П.С. , Подпругина С.В. , Майльянц Э.А. , Саруханян С.С. 
Published: February 2025

Наблюдается рост заболеваемости коклюшем среди взрослого населения, особенно заметный после пандемии COVID-19, когда в начале 2024 г. зарегистрировано значительное увеличение числа случаев заболевания в США, Европе и России. В статье обсуждается эффективность вакцин против коклюша у взрослых с акцентом на особенности иммунного ответа и значимость ревакцинации. Отмечается, что бесклеточные вакцины обеспечивают высокий уровень иммунитета со значительным увеличением титров антител Immunoglobulin G и Immunoglobulin A. Ревакцинация у взрослых характеризуется существенным повышением уровней антител и обеспечением длительной защиты от коклюша, несмотря на более высокую частоту местных побочных эффектов по сравнению с цельноклеточными вакцинами. Осуществлен анализ эффективности вакцинации беременных женщин бесклеточными вакцинами в третьем триместре беременности, отмечена важность ревакцинации женщин данной группы риска. Вакцинация против коклюша у взрослых является эффективным методом предотвращения распространения заболевания, однако требуются стандартизация протоколов вакцинации и проведение дополнительных исследований для оптимизации стратегий ревакцинации.
An increase in pertussis incidence among adults has been observed, particularly notable after the COVID-19 pandemic, with a significant rise in the United States, Europe, and Russia in early 2024. The article discusses the effectiveness of pertussis vaccines in adults, focusing on immune response characteristics and the importance of revaccination. Acellular vaccines provide a high level of immunity with a significant increase in the titres of Immunoglobulin G and Immunoglobulin A antibodies. Adults’ revaccination is associated with a substantial increase in antibody levels and ensures long-term protection against pertussis, despite a higher frequency of local side effects compared to whole-cell vaccines. The vaccination of pregnant women with acellular vaccines in the third trimester is analyzed, emphasizing the importance of revaccination for this high-risk group. In adults, the vaccination against pertussis is an effective method for preventing the disease spread; however, the vaccination protocols standardization and further research are needed to optimize revaccination strategies.
Gambaran Nilai Utilitas Kesehatan Anak dengan Malnutrisi : Studi pada Kasus Stunting, Wasting, dan Underweight di Indonesia
Authors: Bahar Muh. Akbar , Galistiani Githa Fungie , Eliyanti Uzma , Mohi Abdul Rafik 
Published: February 2025

Kondisi malnutrisi seperti stunting, wasting, dan underweight tidak hanya berdampak pada pertumbuhan fisik, tetapi juga dapat memengaruhi kualitas hidup anak secara keseluruhan, termasuk perkembangan kognitif, sosial, dan emosional. Namun, data mengenai nilai utilitas kesehatan anak dengan malnutrisi di Indonesia masih terbatas. Penelitian ini bertujuan untuk memberikan gambaran mengenai nilai utilitas kesehatan pada anak-anak di Indonesia yang mengalami stunting, wasting, dan underweight yang dibandingkan dengan anak sehat. Desain penelitian adalah cross sectional yang dilakukan di Kota Makassar dan Kabupaten Banyumas dari bulan Juli 2024 hingga Agustus 2024 pada anak usia > 2 hingga 5 tahun dengan atau tanpa malnutrisi (stunting, wasting atau underweight). Data dikumpulkan menggunakan kuesioner EQ-5D-5L yang diisi melalui wawancara langsung (face-to-face interview) ke orang tua atau wali dari anak. Hasil pengukuran kuesioner EQ5D-5L dikonversi menjadi nilai utilitas menggunakan value-set EQ5D-5L untuk populasi Indonesia. Data dari 174 anak balita berhasil dikumpulkan dan dibagi menjadi empat kelompok: anak sehat (n=36), stunting (n=55), wasting (n=30), dan underweight (n=53). Hasil analisis menunjukkan bahwa anak balita sehat memiliki nilai utilitas yang signifikan lebih tinggi (0,85 ± 0,11) dibandingkan dengan anak stunting (0,76 ± 0,13), underweight (0,74 ± 0,18), dan wasting (0,72 ± 0,17), dengan nilai p = 0,003. Namun, tidak ditemukan perbedaan signifikan antara kelompok anak dengan gangguan gizi (p > 0,05). Anak balita dengan malnutrisi cenderung memiliki nilai utilitas kesehatan yang lebih rendah dibandingkan anak sehat. Namun, tidak didapatkan perbedaan yang bermakna pada nilai utilitas kesehatan antar kelompok anak yang mengalami malnutrisi.
Progress in Green Chemistry: Sustainable Approaches in Organic Synthesis
Authors: Dr. Vishal Pathak  
Published: February 2025

In order to create ecologically friendly procedures, guidelines, and synthetic techniques that support "global sustainability, chemists, chemists, medicinal chemists, and chemical engineers" may build upon the principles of green (sustainable) chemistry. One of the main tenets of green chemistry, catalysis, is essential for reducing environmental damage. A systemic transformation of the chemical industry is essential to achieve sustainability, with digitalization emerging as a key enabler by enhancing data accessibility and fostering innovation in chemistry and materials R&D. Advances in green organic synthesis, including the use of green solvents, recyclable catalysts, solvent-free reactions, and energy-efficient techniques such as microwave and ultrasonic-assisted approaches, offer eco-friendly alternatives to traditional methods. However, the chemical industry and academic research still predominantly rely on hazardous catalysts and solvents. The adoption of sustainable methodologies is imperative to reduce environmental harm and drive the transition toward greener, safer, and more efficient chemical processes.
AVANÇOS NA RECONSTRUÇÃO MAMÁRIA PÓS-MASTECTOMIA: IMPACTOS NA AUTOIMAGEM E NA QUALIDADE DE VIDA
Authors: Cavalcante Andreia Karla de Carvalho Barbosa , Carneiro Rivia dos Santos , Silva João Francisco Xavier , Santos José Ricardo Lima , Silva Jerônimo Oliveira da , Pacheco Hugo Cezar , Sousa Agnes Vicente de , Rates Henrique Gouvêa , Schichman Luísa Lage , Cavalcante Marcelo Leite 
Published: February 2025

Introdução: A mastectomia é um procedimento essencial no tratamento do câncer de mama, mas pode gerar impactos significativos na autoimagem e na qualidade de vida das mulheres, uma vez que a mama está associada à feminilidade e à identidade corporal. Pesquisas apontam que a proteção mamária contribui para a recuperação emocional e social dos pacientes, promovendo melhora na autoestima e redução dos sintomas depressivos. Além disso, avanços tecnológicos ampliaram as opções cirúrgicas, oferecendo técnicas cada vez mais seguras e eficazes. Objetivo: Analisar os avanços na manutenção mamária pós-mastectomia e seus impactos na autoimagem e na qualidade de vida das pacientes.

Métodos: Trata-se de uma revisão integrativa da literatura, realizada a partir da busca de estudos nas bases de dados PubMed, SciELO, LILACS e Web of Science, publicadas entre 2013 e 2025. Foram selecionados artigos que abordam as principais técnicas reconstrutivas e seus efeitos físicos e psicossociais. Resultados e conclusão: A revisão aponta que a supervisão mamária está diretamente associada à melhoria da qualidade de vida, proporcionando benefícios na autoimagem, na sexualidade e na saúde mental dos pacientes. Técnicas como retalhos autólogos e implantes de última geração apresentam bons resultados estéticos e funcionais, reduzindo o impacto psicológico da mastectomia. No entanto, desafios como o acesso desigual ao procedimento e a necessidade de suporte psicológico contínuo ainda precisam ser enfrentados. Desta forma, destaca-se a importância de políticas públicas que ampliem a oferta de assistência mamária e garantam assistência integral às mulheres no período pós-operatório.
Bendopnea in Geriatric Patients with Different Body Composition Parameters: An Observational Study
Authors: Sergeeva V. A. , Bulgakova S. V. , Runikhina N. K. , Ponedelnikova E. V. 
Published: February 2025

Bendopnea, a recently described new symptom of dyspnea that occurs during trunk flexion, and the bending oxygen saturation index (BOSI) are of interest for further research and application in geriatric practice.OBJECTIVE: The aim of this study was to investigate the incidence of bendopnea in geriatric patients with varying body composition, including obesity, sarcopenia, and sarcopenic obesity.MATERIALS AND METHODS. The bendopnea symptoms and the BOSI were studied in a cross-sectional, observational study involving 100 individuals of advanced age with sarcopenia or sarcopenic obesity as well as control groups with obesity or no sarcopenia/sarcopenic obesity. Bendopnea was defined as dyspnea occurring after 30 seconds of transverse trunk flexion in a seated position of patient. Simultaneously, the BOSI was calculated by subtracting the oxygen saturation values before and after the bendopnea test, using pulse oximetry.RESULTS. The average age of the participants was 76.16 ± 7.71 years, with women accounting for the majority (72%). The group with sarcopenic obesity showed the highest number of positive bendopnea symptoms (65.38%), with statistically significant differences compared to the group with sarcopenia (26.92%) (p = 0.01); the group with obesity without sarcopenia (30.77%) (p = 0.01) and the control group (22.73%) (p < 0.001), respectively. The bendopnea was most commonly reported in patients actively experiencing dyspnea, with higher scores on the Borg dyspnea scale and severity on the Modified Medical Research Council (mMRC) scale. These patients also had lower grip strength, higher waist circumferences, and body mass index. No statistically significant differences were found when comparing the BOSI indices of patients with and without positive bendopnea.CONCLUSION. Bendopnea may be a promising additional diagnostic tool for dyspnea in older patients. Given its high incidence in sarcopenic obesity, further studies are required to assess its prognostic value in this category of older patients.
The Effect Of Liquidity, Leverage And Profitability On Company Value
Authors: Permata Adilla Cahya , Muktiadji Nusa , Khim Soei , Silaen Uluan 
Published: February 2025

This Study aiming to know how influence Liquidity, Leverage, and Profitability On Company Value. In sub sector companies pharmacy. Research use approach quantitative. Data collection techniques sample use purposive sampling with amount sample as many as 7 companies. The type of data used is secondary data from report finance 2018-2022. This Study use statistical analysis and multiple linear analysis with using SPSS 26. The results of partial test research or t test shows that variable Liquidity (current ratio) and profitability (return on assets) have an effect to Company Value (price to book value), whereas Leverage (debt to equity ratio) no influential to Company Value (price to book value). Based on simultaneous testing or the f test shows that variable Liquidity (current ratio), leverage (debt to equity ratio), and profitability (return on assets) have an effect to Company Value (price to book Value).

Keywords :​ Liquidity (current ratio), leverage (debt to equity ratio), and profitability (return on assets) have an effect to Company Value (price to book Value).
Unveiling the Interior Structure and Thermal Evolution of Super-Earth GJ 486b
Authors: Sahu Chandan K. , Majumdar Liton , Mridha Sudipta , Krishna Harshit 
Published: February 2025

Abstract
Recent ground- and space-based surveys have shown that planets between Earth and Neptune in size, known as “super-Earths,” are among the most frequently found planets in the Galaxy. Although the JWST era has provided high-quality atmospheric data on many such super-Earths, modeling tools are crucial for understanding their unobservable interiors. Consequently, interior studies represent the next essential step in gaining a comprehensive understanding of this class of exoplanets. This study investigates the interior structure, thermal evolution, and atmospheric dynamics of the super-Earth GJ 486b using SERPINT, a 1D self-consistent coupled interior structure and evolution model, aiming to understand the planet’s thermal evolution based on an Earth-like structure. Our results indicate that GJ 486b’s core is approximately 1.34 times larger than Earth’s, with a core pressure of about 1171 GPa. The thermal evolution model predicts that the planet’s mantle cools and solidifies over approximately 0.93 Myr. As the magma ocean cools, water is released from the melt, forming a water-rich atmosphere during early solidification. Photolysis of water vapor and subsequent hydrogen escape lead to oxygen accumulation, forming a water- and oxygen-rich secondary atmosphere. Future high-sensitivity JWST observations, with improved wavelength coverage and the detection of additional trace gases, will enable a detailed analysis of the planet’s atmospheric composition, providing crucial insights into the interior, surface, and subsurface properties of GJ 486b.
Virtuosas e claras mugeres de Álvaro de Luna: escritura y erudición en la corte de Juan II
Authors: Marini Massimo 
Published: February 2025

El tratado de don Álvaro de Luna titulado Virtuosas e claras mugeres (1446) se inserta en el debate sobre la mujer que, desde Cataluña, aviva la actividad literaria de la corte castellana, especialmente a partir de los años Treinta del siglo XV. Como han demostrado las ediciones críticas y los estudios de conjunto del texto, la compilación de Álvaro de Luna presenta estratificaciones lingüísticas y estilísticas que coinciden con la división de los libros y dependen de las fuentes utilizadas en cada una de ellas. Tomando como punto de partida una de las biografías del segundo libro, la de la heroína romana Clelia, el trabajo pretende ejemplificar el uso de las fuentes y de los materiales por parte del autor, para enmarcar su obra en el clima cultural cuatrocentista, tan fundamental para el desarrollo y evolución de las letras hispanas en épocas posteriores.
Entre genre et espèces : héroïnes végétales, intersections médiévales
Authors: Genest Viviane 
Published: February 2025

La question de l’articulation entre l’humain et l’animal a fait l’objet de plusieurs travaux au sein des sciences humaines qui montre sa corrélation avec des logiques de domination et de hiérarchisation. Qu’en est-il pour le végétal ? Quels liens, analogies, continuités ont pu être formulées entre les plantes et l’humain ? De récentes études ont souligné que le Moyen Age est une période charnière pour l’élaboration en Occident d’une pensée du vivant. Le présent article postule que ce long temps d’incubation ne s’est pas contenté de mettre en mots un discours ayant pour seul objet le végétal. Il s’agit toujours en réalité de penser les êtres vivants de façon relationnelle, par rapport à l’humain. Toutefois, du Moyen Age central à la fin de la période a lieu une bascule qui fait passer de conceptions plutôt vitalistes où le végétal est pensé dans une forme de continuité avec une humanité peu ou pas appréhendée en termes de genre, à des conceptions qui, par petites touches insistantes, établissent des corrélations entre féminin et végétal, notamment pour ce qui touche la physiologie. Dans des corpus variés, mais influencés notamment par les textes encyclopédiques, se fait jour une intersection entre genre et espèce, en même temps que dans le domaine lexical, sous l’influence de la pensée aristotélicienne, le sémantisme veget* va être associé à la passivité. Le présent article, exploratoire, propose une exploration de corpus variés pour affiner et documenter ce changement, dans le cadre d’une recherche en cours.
The Lens Flare. Photorealistic Computer Graphics between Physics and Economic Viability
Authors: Schröter Jens 
Published: February 2025

Since roughly the 1970s, the quest for photorealism has been the driving force behind computer graphics. The goal is not only to render scenes in such a way that they look “realistic,” but specifically to render scenes in a way that they look as if they were photographed. The initial motivation for this was to integrate scenes produced with computer graphics into films that were otherwise recorded photographically. Producing images that look like photos also means reproducing some effects typical of photographic image-making processes like different kinds of blur and specific disturbances like lens flares. The simulation of lens flares is the topic of this essay, which, through close analysis of one computer science paper, will show that the processes of simulating photography are always caught between two different and competing goals: on the one hand, there is the idea of simulating a given photographic property—lens flare in the case of this paper— in a way that is physically correct, a process that may need considerable computational resources and time. On the other, there is the economic goal of performing the rendering efficiently and at comparatively low cost.
Ce que la Constitution de 1976 retient de la révolution des Œillets. Analyse juridique du processus et des débats constituants
Authors: Connil Damien , Löhrer Dimitri 
Published: February 2025

L’article analyse, sous l’angle du droit constitutionnel, la place et l’importance de la révolution des Œillets dans l’élaboration de la Constitution portugaise de 1976. Dans cette perspective sont examinées l’influence de la dynamique révolutionnaire sur le processus et l’empreinte de la révolution sur les débats constituants. L’étude entend ainsi contribuer à une meilleure connaissance du lien consubstantiel, au Portugal, entre le phénomène révolutionnaire de 1974 et le mouvement constituant de 1976.
Inorganico pre e post-umano: Giacomo Leopardi e la geologia nelle Operette morali
Authors: Ambrosino Gennaro 
Published: February 2025

Dalla metà del Settecento, le scienze della Terra, e in particolare la geologia, hanno conosciuto un rapido sviluppo, segnato dal confronto tra diverse correnti (nettunisti e plutonisti, uniformisti e catastrofisti) e dalla proliferazione di numerose teorie della Terra. Questo periodo è culminato negli anni Trenta dell’Ottocento con la pubblicazione dei Principles of Geology (1830‑1833) di Charles Lyell (1797‑1875). In questo articolo, intendo esaminare la conoscenza geologica di Giacomo Leopardi e il suo utilizzo nei testi letterari, mostrando come l’analisi del sapere geologico permetta, da un lato, di evidenziare consonanze e affinità tra Leopardi e alcuni scienziati e filosofi della natura, tra cui Lyell, William Hamilton (1730‑1803), James Hutton (1726‑1797) e Alberto Fortis (1741‑1803); dall’altro, consenta di approfondire e rileggere in modo innovativo alcuni aspetti del pensiero filosofico di Leopardi. Mi concentrerò in particolare sull’uso dell’immaginario geologico nelle Operette morali, rileggendo la critica all’antropocentrismo di Leopardi alla luce del concetto geologico di deep time e la permeabilità delle categorie di organico e inorganico alla luce del principio geologico dell’attualismo e del processo di fossilizzazione.
Istinto, animalità e irriflessione nello Zibaldone di Leopardi
Authors: Allegrini Vincenzo 
Published: February 2025

Il saggio ricostruisce la costellazione semantica dell’‘istinto’ e dell’‘irriflessione’ nello Zibaldone di Leopardi. Si mostrerà, anzitutto, il complesso (e talvolta contraddittorio) significato che i due termini assumono nelle differenti fasi del pensiero leopardiano, dal 1819 fino al dicembre 1826. Si getterà luce, così, sul legame tra i due lemmi e alcuni temi cruciali della riflessione antropologica e filosofica di Leopardi: l’istinto di conservazione, la corruzione dell’uomo e la nascita della «società stretta», la legge naturale e la virtù morale, l’egoismo, l’invidia, il piacere, il desiderio, l’amor proprio, le illusioni e le credenze, il danno del conoscere, il timore, la compassione, il problema della contraddittorietà dell’essere e, dunque, del male. Nel fare ciò, emergerà come i due lemmi traccino percorsi uguali e contrari, in linea con la tortuosa ricerca da parte di Leopardi di un possibile antidoto contro la corruzione dell’animale‑uomo, singolarmente incline sia all’eccesso della ragione sia all’irriflessione brutale.
La sobriété, fin ou moyen ?
Authors: Lemarchand Frédérick , Lasnon Louis 
Published: February 2025

Aborder la question de la sobriété énergétique exige à tout le moins un effort d’interdisciplinarité tant l’objet « énergie » est hybride. Hautement matériel, puisque l’énergie est à la base de tout (y compris du vivant), l’objet est aussi social et détermine largement les formes d’organisation sociale et économique basées sur la croissance matérielle, elle-même dépendante… de la quantité d’énergie que reçoit le système. Ceci constituera la première partie de notre réflexion. Dire qu’il nous faut décarboner, pour des raisons vitales, nos modes de production et nos styles de vie ne suffit pas. En effet l'épaisseur du social, la complexité de l’humain opposent des freins et de farouches résistances à l’adoption de modes de vie plus frugaux, lesquels seront abordés dans un second temps. Dans un troisième temps enfin, dans la perspective d’une approche plus pragmatique et méthodologique, nous aborderons les enjeux du métabolisme territorial, mettant en relation les communautés humaines et leur milieu, à partir d’une ethnocomptabilité.