bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cardiovascular disease in patients with inflammatory rheumatic disease is associated with up‐regulation of markers of inflammation in cardiac microvessels and cardiomyocytes
Authors: Grundtman Cecilia , Hollan Ivana , Førre ØYstein T. , Saatvedt Kjell , Mikkelsen Knut , Lundberg Ingrid E. 
Published: January 2010

AbstractObjectiveVarious inflammatory rheumatic diseases (IRDs) are associated with increased mortality due to cardiovascular disease. The aim of this study was to investigate heart biopsy specimens obtained from patients undergoing coronary artery bypass grafting and compare markers of inflammation and endothelial cell activation in the cardiac and skeletal muscle of patients with and those without IRD.MethodsPaired biopsy specimens of cardiac and skeletal muscle were obtained from 22 consecutive patients with IRD and 8 patients without IRD, all of whom were undergoing coronary artery bypass grafting. The biopsy specimens were evaluated in a blinded manner by conventional microscopy and digital image analysis for cell markers (CD3, CD4, CD8, CD68, CD163, and CD31), HLA (HLA–ABC, HLA–DR, and HLA–DQ), adhesion molecules (intercellular adhesion molecule 1 and vascular cell adhesion molecule 1), and proinflammatory cytokines (interleukin‐1α, interleukin‐1β, and tumor necrosis factor).ResultsPatients with IRD had significantly higher expression of adhesion molecules, proinflammatory cytokines, and all classes of HLA on cardiomyocytes and endothelial cells but no increase on mononuclear cells in the myocardium compared with patients without IRD. Furthermore, cardiac muscle from patients with IRD displayed significantly higher local expression of inflammation and activation of cardiac microvessels compared with skeletal muscle from the same patients.ConclusionPatients with cardiovascular disease had increased expression of adhesion molecules, HLA, and proinflammatory cytokines in heart tissue, indicating local inflammation involving microvessels and cardiomyocytes that could play a role in the pathogenesis of cardiovascular disease. The more pronounced changes in patients with IRD compared with patients without IRD might contribute to the increased risk of cardiovascular disease and premature death in patients with IRD.
Antibodies to apolipoprotein A‐I, high‐density lipoprotein, and C‐reactive protein are associated with disease activity in patients with systemic lupus erythematosus
Authors: O'Neill Sean G. , Giles Ian , Lambrianides Anastasia , Manson Jessica , D'Cruz David , Schrieber Leslie , March Lyn M. , Latchman David S. , Isenberg David A. , Rahman Anisur 
Published: January 2010

AbstractObjectiveInflammatory disease activity in patients with systemic lupus erythematosus (SLE) may affect the development of atherosclerosis, contributing to their increased risk of cardiovascular disease (CVD). This process may be mediated by anti–apolipoprotein A‐I (anti–Apo A‐I), anti–high‐density lipoprotein (anti‐HDL), and anti–C‐reactive protein (anti‐CRP) autoantibodies. We undertook this study to examine whether levels of these antibodies rise in association with increased SLE disease activity.MethodsIgG anti–Apo A‐I, anti‐HDL, and anti‐CRP levels were measured in serum from the following groups: 39 patients with persistently high disease activity (British Isles Lupus Assessment Group [BILAG] A or B score) over the previous 2 years, 42 patients with persistently low disease activity (no BILAG A or B scores) over the previous 2 years, 34 healthy controls, 25 individual patients from whom paired samples (at time of disease flare and quiescence) were obtained and compared, 16 patients with newly diagnosed lupus nephritis from whom multiple samples were obtained and who were followed up prospectively for up to 2 years, and 24 patients with SLE who had experienced CVD events.ResultsSerum levels of IgG anti–Apo A‐I, anti‐HDL, and anti‐CRP were higher in patients with SLE than in controls. Anti–Apo A‐I and anti‐HDL levels, but not anti‐CRP levels, were higher in patients with persistently high disease activity than in those with low disease activity. Mean levels of the 3 autoantibodies in patients who had experienced CVD events lay between the mean levels in the high and low disease activity groups. Only levels of anti–Apo A‐I were significantly higher in samples obtained from individual patients during disease flares than in samples obtained during disease quiescence. In the lupus nephritis patients, anti–Apo A‐I and anti‐HDL levels correlated with serum levels of high avidity IgG anti–double‐stranded DNA.ConclusionPersistent disease activity is associated with a significant increase in IgG anti–Apo A‐I and anti‐HDL in patients with SLE.
Endothelin 1 contributes to the effect of transforming growth factor β1 on wound repair and skin fibrosis
Authors: Lagares David , García‐Fernández Rosa Ana , Jiménez Clara López , Magán‐Marchal Noemi , Busnadiego Oscar , Lamas Santiago , Rodríguez‐Pascual Fernando 
Published: January 2010

AbstractObjectiveTo characterize the pathways induced by transforming growth factor β1 (TGFβ1) that lead to the expression of endothelin 1 (ET‐1) in human dermal fibroblasts, and to study the effects of TGFβ1 and ET‐1 on the acquisition of a profibrotic phenotype and assess the contribution of the TGFβ1/ET‐1 axis to skin wound healing and fibrosis in vivo.MethodsThe mechanism of induction of ET‐1 expression by TGFβ1 and its effect on the expression of α‐smooth muscle actin and type I collagen were studied in human dermal fibroblasts, in experiments involving the TGFβ receptor inhibitor GW788388 and the ET receptor antagonist bosentan, by real‐time reverse transcription–polymerase chain reaction (RT‐PCR), enzyme‐linked immunosorbent assay, immunofluorescence, Western blotting, and promoter/reporter transient transfection analyses. Experiments assessing dermal wound healing in mice were performed with adenovirus‐driven overexpression of active TGFβ1 and ET‐1, with or without treatment with bosentan. The contributions of TGFβ1 and ET‐1 to the fibrotic response were also assessed in a mouse model of bleomycin‐induced skin fibrosis, by histologic, immunohistochemical, RT‐PCR, and protein analyses.ResultsTGFβ1 induced ET‐1 expression in human dermal fibroblasts through Smad‐ and activator protein 1/JNK–dependent signaling. The ability of TGFβ1 to induce the expression of profibrotic genes was dependent on ET‐1. Adenovirus‐mediated overexpression of TGFβ1 and ET‐1 in mouse skin was associated with accelerated wound closure, increased fibrogenesis, and excessive scarring. Treatment with bosentan prevented the effects of TGFβ1. In the bleomycin‐induced fibrosis model, treatment with GW788388 and bosentan prevented the fibrotic response.ConclusionOur results strongly support the notion that the TGFβ1/ET‐1 axis has a role in wound repair and skin fibrosis. ET‐1 receptor antagonists, such as bosentan, may represent a useful therapeutic tool in the treatment of excessive scarring and fibrosis‐related diseases.
ChemInform Abstract: (Cu2S2)(Sr3Se2O5) — A Layered, Direct Band Gap, p‐Type Transparent Conducting Oxychalcogenide: A Theoretical Analysis.
Authors: Scanlon David O. , Watson Graeme W. 
Published: January 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis, Characterization and Low Temperature Studies of Iron Chalcogenide Superconductors.
Authors: Janaki J. , Kumary T. Geetha , Mani Awadhesh , Kalavathi S. , Reddy G. V. R. , Rao G. V. Narasimha , Bharathi A. 
Published: January 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Structure and Electrochemical Performance of FeF3/V2O5 Composite Cathode Material for Lithium‐Ion Battery.
Authors: Wu Wen , Wang Ying , Wang Xianyou , Chen Quanqi , Wang Xin , Yang Shunyi , Liu Xiuming , Guo Jia , Yang Zhenhua 
Published: January 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Production of Hydrogen from Reactions of Methane with Boranes.
Authors: Swinnen Saartje , Nguyen Vinh Son , Sakai Shogo , Nguyen Minh Tho 
Published: January 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: A Simple Route to Synthesize New Binary Cobalt Iron Cyclotetraphosphate CoFeP4O12 Using Aqueous and Acetone Media.
Authors: Boonchom Banjong , Thongkam Montree , Kongtaweelert Samart , Vittayakorn Naratip 
Published: January 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Application of Enantiopure 1‐(Aminoalkyl)naphthols and 2‐(Aminoalkyl)phenols in the Enantioselective Addition of Organozinc to α,β‐Unsaturated Carbonyl Compounds.
Authors: Cimarelli Cristina , Fratoni Davide , Palmieri Gianni 
Published: January 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Iminium‐Ion Activation as an Efficient Strategy for Divergent Synthesis of Optically Active Propargylic, Homopropargylic, and Allenic Compounds.
Authors: Jiang Hao , Holub Nicole , Paixao Marcio W. , Tiberi Caterina , Falcicchio Aurelia , Joergensen Karl Anker 
Published: January 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Towards Sustainable Homogeneous Gold Catalysis: Cycloisomerization of Functionalized Allenes in Water.
Authors: Winter Christian , Krause Norbert 
Published: January 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: One‐Pot Protocol for Synthesis of α‐Organosulfonyloxy Ketones from Secondary Alcohols Using Hypervalent Iodine(V)‐Mediated Oxidations.
Authors: Deshmukh Swapnil S. , Huddar Sameerana N. , Akamanchi Krishnacharya G. 
Published: January 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: A Novel Catalytic Method for the Oxidation of Sulfides to Sulfoxides with Silica Sulfuric Acid and Sodium Nitrite in the Presence of KBr and/or NaBr as Catalyst.
Authors: Goudarziafshar Hamid , Ghorbani‐Choghamarani Arash , Nikoorazm Mohsen , Naserifar Zahra 
Published: January 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Polyethylene Glycol as a Nonionic Liquid Solvent for the Synthesis of N‐Alkyl and N‐Arylimides.
Authors: Liang Jun , Lv Jing , Fan Ji‐cai , Shang Zhi‐cai 
Published: January 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Iron Complex Catalyzed N‐Arylation of Pyrazoles under Aqueous Medium.
Authors: Lee Hang Wai , Chan Albert S. C. , Kwong Fuk Yee 
Published: January 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Highly Regio‐ and Stereoselective Synthesis of (Z)‐Trisubstituted Alkenes via Propyne Bromoboration and Tandem Pd‐Catalyzed Cross‐Coupling.
Authors: Wang Chao , Tobrman Tomas , Xu Zhaoqing , Negishi Ei‐ichi 
Published: January 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis of trans‐Fused Sesquiterpenoid Analogues by Zirconocene‐Mediated Metallo‐ene Reaction.
Authors: Korotvicka Ales , Hybelbauerova Simona , Kotora Martin 
Published: January 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Asymmetric Synthesis of Propargylic Alcohols Catalyzed by (‐)‐MITH.
Authors: Wu Ping‐Yu , Wu Hsyueh‐Liang , Shen Ying‐Ying , Uang Biing‐Jiun 
Published: January 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: An Efficient Tris‐(2‐aminoethyl)amine‐CuI‐Catalyzed Thioetherification of Thiols with Aryl Halides.
Authors: Jogdand Nivrutti R. , Shingate Bapurao B. , Shingare Murlidhar S. 
Published: January 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Malononitrile‐Catalyzed and Highly Selective Method for the Synthesis of 2‐((E)‐1,3‐Diarylallylidene)malononitriles in Ionic Liquid.
Authors: Wang Xiang‐Shan , Zhang Mei‐Mei , Li Qing , Yao Chang‐Sheng 
Published: January 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Diethylzinc: A Simple and Efficient Catalyst for the Swift Hydroamination at Room Temperature.
Authors: Pissarek Jens‐Wolfgang , Schlesiger David , Roesky Peter W. , Blechert Siegfried 
Published: January 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Efficient Synthesis of Substituted Thieno[3,2‐e]indoles.
Authors: Van Snick Wim , Dehaen Wim 
Published: January 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Direct Oxidative Conversion of Benzoyl Chlorides to 2‐Imidazoles Using Heteropolyacids.
Authors: Sadjadi Samaheh , Heravi Majid M. , Poormohammad Narges , Oskooie Hossein A. , Beheshtiha Yahya. Sh. , Bamoharram Fatemeh F. 
Published: January 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Reaction of Esters of 2‐Arylcyclopropanecarboxylic Acids with Nitrous Acid. Synthesis of Aryl‐Substituted 3‐Ethoxycarbonyl‐4,5‐dihydroisoxazoles and 3‐Ethoxycarbonylisoxazoles.
Authors: Kadzhaeva A. Z. , Trofimova E. V. , Fedotov A. N. , Potekhin K. A. , Gazzaeva R. A. , Mochalov S. S. , Zefirov N. S. 
Published: January 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: 2,3‐Dihydro‐4H‐pyran‐4‐ones and 2,3‐Dihydro‐4‐pyridinones by Cyclizations of α,β‐Unsaturated 1,3‐Diketones.
Authors: MacDonald Franklyn K. , Burnell D. Jean 
Published: January 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Gallium(III) Chloride Catalyzed Three‐Component Coupling of Naphthol, Alkyne and Aldehyde: A Novel Synthesis of 1,3‐Disubstituted‐3H‐benzo[f]chromenes.
Authors: Yadav J. S. , Reddy B. V. Subba , Biswas Swapan Kumar , Sengupta Sandip 
Published: January 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Convenient Synthesis of 6‐Bromo‐1,2,3,4‐tetrahydroisoquinoline and 3‐Methoxy‐1,2,3,4‐tetrahydro‐[2,7]‐naphthyridine via Reductive Amination of Schiff′s Bases.
Authors: Zlatoidsky Pavol , Gabos Balint 
Published: January 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: First Synthesis of 5‐Chloro‐7‐[1,3]oxazolo[4,5‐b]pyridin‐2‐ylquinolin‐8‐ol (VI) by Pd‐Catalyzed Arylation.
Authors: Sakee Uthai , Grigg Ronald 
Published: January 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Discovery and in vitro and in vivo Profiles of 4‐Fluoro‐N‐[4‐ [6‐(isopropylamino)pyrimidin‐4‐yl]‐1,3‐thiazol‐2‐yl]‐N‐methylbenzamide as Novel Class of an Orally Active Metabotropic Glutamate Receptor 1 (mGluR1) Antagonist.
Authors: Kawamoto Hiroshi , et al. et al. 
Published: January 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis and Single Crystal X‐Ray Structure of Bis[4‐oxo‐3‐(2‐ethoxycarbonylphenyl)‐3,4‐dihydroquinazolin‐2‐yl] disulfide.
Authors: Rimaz Mehdi , Khalafy Jabbar , Tavana Khadijeh , Slepokura Katarzyna , Lis Tadeusz , Souldozi Ali , Mahyari Amir Tofangchi , Shajari Nahid , Ramazani Ali 
Published: January 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Syntheses and Characterization of the Pyrimido[1,2‐a][1,3,5]triazinthione as a New Ring System and Antibacterial Agent.
Authors: Waly M. A. , Abou Dobara M. I. 
Published: January 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Asymmetric Synthesis of 3‐ or 4‐Alkyl or Arylbenzo[c]azepines.
Authors: Dumoulin David , Lebrun Stephane , Couture Axel , Deniau Eric , Grandclaudon Pierre 
Published: January 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis of Bis(polyfluoroalkylated)imidazolium Salts as Key Intermediates for Fluorous NHC Ligands.
Authors: Skalicky Martin , Rybackova Marketa , Kysilka Ondrej , Kvicalova Magdalena , Cvacka Josef , Cejka Jan , Kvicala Jaroslav 
Published: January 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.