bluuebunny/crossref_metadata_2025_split huggingface dataset:
Design and realization of the digital protection platform of traditional intangible cultural heritage based on virtual reality technology
Authors: Zhang Chao , Duan Limin , Hu Bin , Xue Yao , Cheng Yun , Wang Yang 
Published: May 2024

Abstract
Using new design concepts and design methods to effectively strengthen the digital protection of traditional non-heritage culture is an important measure to promote the development of conventional non-heritage culture. In this paper, the digital protection needs of traditional non-heritage culture are sorted out, including the purpose of digital protection of non-heritage, the design level, and the feasibility of the application of virtual reality technology in the digital protection of non-heritage culture. A platform for the digital protection of non-heritage culture is constructed with the model of PHP technology + MySQL database + Apache server combined with virtual reality technology, and the immersion experience and display dissemination model is designed in this platform. In order to obtain accurate digital images of traditional non-heritage culture, this paper utilizes 3D laser point cloud acquisition technology to reconstruct non-heritage culture in 3D. It combines the ICP algorithm to enhance the point cloud alignment accuracy of digital images of non-heritage culture. Evaluation of the effectiveness of the traditional non-heritage culture digital protection platform proposed in this paper was done through performance tests and application practice. The results show that the number of concurrent users of the platform in this paper can reach the maximum throughput of about 94,300 per second in 2000, the point cloud alignment accuracy of the ICP algorithm has an error of only 0.304mm, and the SUS usability evaluation of the platform scores 80.4 points. The construction of a digital protection platform for non-heritage culture using virtual reality technology can provide users with immersive experience scenes.
The practice and prospect of algorithm-driven virtual simulation technology in medical undergraduate education
Authors: Tao Lili , Tao Qianshan 
Published: May 2024

Abstract
Amid growing interest in the use of virtual simulation platforms in educational settings, the reform of medical education increasingly looks to virtual simulation technology as a promising new avenue. This study aims first to analyze the components of a virtual simulation system and to enhance the functionality of virtual simulation technology by optimizing the network model algorithm. Utilizing cloud computing technology, a virtual simulation teaching experiment platform was constructed. Further, a virtual simulation medical education system based on the BOPPPS teaching model was developed to address the constraints of practical experience in the traditional undergraduate medical education model. Empirical analysis of the virtual simulation medical education mode reveals that the CPU utilization rate on the constructed cloud platform ranged from 2% to 35%, and the memory usage varied between 15 and 25 GB. In comparative assessments of medical education practices, this study found that students trained under the virtual simulation technology-enhanced model scored 0.96 to 1.53 points higher in various skill assessments than those trained under traditional methods. Moreover, the total scores for communication abilities increased by 5.48 points, highlighting a significant improvement. These results affirm the superiority of the virtual simulation technology medical education model presented in this study. They underscore its practicality and feasibility for application and development in undergraduate medical education, providing a substantive pathway for integrating advanced virtual simulation technologies into medical training.
Analysis of Influential Factors of Ideological and Political Education Reform in Colleges and Universities--Based on Multiple Linear Regression Perspective
Authors: Shao Yiming 
Published: May 2024

Abstract
The reform of ideological and political education in higher education encompasses a broad spectrum of challenges, many of which continue to impede its effectiveness. This paper delves into these reforms by constructing an index system of factors that influence the effectiveness of ideological and political education, and it posits several research hypotheses. Within this framework, factors identified from the index system serve as independent variables, while the efficacy of ideological and political education reforms serves as the dependent variable. A multiple linear regression model is employed to analyze these relationships, with evaluations conducted through fit, residual, and variance tests. Correlation analysis is utilized to explore the interactions among the influencing factors, and hypothesis testing is performed on each variable in relation to the impact of Civic and Political Education reform. The analysis reveals that teacher-level factors provide a substantial explanatory power of 79.6%, positively impacting the reform efforts. Conversely, the regression correlation coefficient at the student level stands at 0.165, indicating a negligible linear relationship with the reform outcomes. All hypotheses were validated, with the exception of H5. This study not only provides a foundational reference for enhancing current reforms in Civic and Political Education but also lays the groundwork for future strategic planning in this crucial educational domain.
Comparing the efficiency of maxillary protraction using digital cooperation monitoring in ages 4–7 and 8–11: a prospective study
Authors: Yaradanakul K. , Yilmaz B. 
Published: May 2024

Abstract

Objectives
This study compares the effectiveness of face mask therapy applied after rapid maxillary expansion (RME) in 4- to 11-year-old patients with objective co-operation data collected using thermal sensors. The null hypothesis was that there would be no difference in the effectiveness of the maxillary protraction.

Materials and method
Initial and post-treatment lateral cephalometric radiographs were taken of patients with maxillary retrognathia, aged between 4 to 7 years (6.1 ± 1.88, n = 13) and 8 to 11 years (9.4 ± 1, n = 12) of age. An RME was performed for at least 10 days. The face mask protraction force was set to 450 g per side, and the recommended usage was 10 hr per day. TheraMon® microsensors were integrated into the face mask.

Results
The daily usage was significantly higher in the younger age group (8.9 ± 1.8 hr) compared to the older group (7.1 ± 0.9 hr). The SNA angle, A-Nasionperp (mm), ANB angle, Wits (mm), maxillary depth, ANS-Me (mm), the molar relationship (mm) and overjet (mm) significantly increased in both groups. Co-A (mm), the saddle angle, articular angle and UL-E Line (mm) showed a significant increase only in the older group, while the L1-A/Pg decreased significantly. The SNB angle decreased significantly only in the younger group. There was no statistically significant difference in the delta values between the two groups.

Conclusion
The null hypothesis was partly rejected since no difference was observed in the examined skeletal and soft tissue parameters.
Living, Caring, Learning – Reflections on the therapeutic relationship in haemophilia care
Authors: Butler Regina 
Published: May 2024

Abstract
Now nearing retirement, Regina, who was involved in establishing a haemophilia programme for children and young adults in the United States, reflects on the therapeutic relationship between haemophilia nurses and their patients. Having been involved in haemophilia nursing in the 1980s, Regina’s practice has been influenced by her experience of caring for young patients who were infected with HIV/ AIDS following treatment with contaminated blood products. She considers compassion and emotion in nurses’ relationships with their patients and highlights the key role of contact with colleagues and peer support, particularly during difficult times. While trust is an essential part of the therapeutic relationship and is valued by both the patient and the nurse, Regina reflects on how this can result in dependence. She points to the importance of setting clear boundaries and how this ensures that the patient establishes trust with the wider team or system delivering their care, not just an individual nurse. In her roles as clinical manager, haemophilia centre director and nurse coordinator, this is now part of the advice she shares with her own team. Despite a sense of caution about new therapies as a result of her experience during the 1980s, Regina has been involved in gene therapy trials and feels that the future looks positive for people with haemophilia.
Living, Caring, Learning – Early education, active lives and tailored treatment in haemophilia care
Authors: Belev Josipa 
Published: May 2024

Abstract
Josipa, a haemophilia nurse in Croatia, describes how meeting 18-year-old twins with severe haemophilia A changed her views around joint health and activity in people with haemophilia. The twins had started prophylaxis at a young age, learning to self-infuse at a haemophilia summer camp, and were both sporty and active. Neither had experienced joint damage and, 20 years later, they continue to live active lives. Josipa reflects on her own experience of volunteering at a haemophilia summer camp and teaching young people with haemophilia to selfinfuse. She highlights the importance of talking with patients about their lives and understanding their lifestyle and circumstances to provide a treatment regimen tailored to the needs of the individual. Reflecting on the benefit of activity and exercise to joint health in people with haemophilia, Josipa describes how this has also inspired her to become a Nordic walking coach. She notes that access to more effective treatments has enabled a focus on quality of life in haemophilia care, and the importance of maintaining good physical health in an ageing haemophilia population.
The strategies of parents who tell their daughters about the possibility of being a haemophilia carrier
Authors: Nozaki Keiko , Yamazaki Akemi 
Published: May 2024

Abstract

Introduction
Women who carry the haemophilia gene have a genetic risk of having a son with haemophilia, as well as the risk of abnormal bleeding; thus, there is an increasing interest in ‘carriers’ as subjects that potentially require medical support. However, in Japan, only about half of individuals with a family history of haemophilia inform their daughters that they may be carriers.

Aims
The purpose of this study was to identify strategies used by parents to inform their daughters about their possibility of being haemophilia carriers.

Method
Parents of daughters with confirmed or suspected carrier status, based on family history, were included in the study. A semi-structured interview was conducted, and data were analysed qualitatively using an inductive approach.

Results
Eight parents (two men, six women) were included. The mean age of participants was 58 (range: 44-70) years; interviews lasted 76 minutes on average (range: 49-100 minutes). Data showed that parents align their values with each other and share information about their daughters between them (information sharing between partners). They also adopt roles according to sex. Mothers often played the primary role in the process of sharing information with their daughters as they are of the same sex. Since all daughters of fathers with haemophilia would be confirmed carriers, fathers were more concerned about how their daughters might react and had more guilt about their daughters. Parents also attempted to prepare for informing their daughters about haemophilia by observing their stage of mental development to determine the optimal timing to have these conversations. When sharing information about haemophilia, parents were careful to inform their daughters while considering their feelings to ensure that daughters received the information in a positive light. After sharing information about haemophilia, parents played the role of ‘daughter’s supporter’ by confirming their level of understanding and their feelings and considering possible ways to support them in the future.

Conclusion
Assessment of carrier status can only begin if parents tell their daughters about the possibility of being a haemophilia carrier. Based on the five strategies identified, medical professionals should provide parents with information about haemophilia carriers and sharing information on genetic risk.
The first reported case of factor X deficiency in a Filipino child – case study
Authors: Masacupan Kristian Dorell , Racho Allan Robert , Del Rosario Maria Luz , Lagara-Aranas Loralyn Mae 
Published: May 2024

Abstract
Factor X (FX) deficiency is an extremely rare inherited bleeding disorder affecting one in 1,000,000 people. According to the most recent published census of the World Hemophilia Federation, to date there is no reported case of FX deficiency in the Philippines. Rare disorders like FX deficiency often go unrecognised or misdiagnosed. Here, we report the first case of FX deficiency in a Filipino child. A two-month-old male child with consanguinity was referred to our hospital due to bleeding episodes. On the third day of life, he had haematomas to the cervical area and upper extremities, and spontaneous bleeding of the umbilical cord was noted. Initial workup showed prolonged PT and aPTT. Factor deficiencies including FVIII and FIX were considered, however assays were normal. At six weeks of age, the child developed convulsions and deteriorating neurologic status. CT scan showed subarachnoid haemorrhage. The child was referred for further workup. Additional assay of clotting factors showed decreased FX activity at less than 1% and he was diagnosed with severe congenital FX deficiency. Following recurrent intracranial bleeding, the child has been observed to have permanent neurological deficit. This case highlights the importance of timely and accurate diagnosis to prevent life-threatening complications and the risk of permanent disability. Despite being an extremely rare disorder, the incidence of FX deficiency is estimated to be higher in populations where consanguineous marriages are common. Awareness of this rare condition must be emphasised. Families may benefit from screening through coagulation studies as well as genetic counselling, especially when planning future pregnancies. The rarity of this condition has not allowed for the establishment of evidence-based management guidelines, with treatment based on limited literature. Despite development of FX-specific clotting factor products, the high cost and limited availability impact their use in low-resource settings.
Factor X deficiency: a comment on two recent case studies
Authors: Branchford Brian 
Published: May 2024

AbstractHereditary factor X deficiency (HFXD) is a rare genetic bleeding disorder, affecting approximately 1 in 1,000,000 individuals globally, and resulting in abnormally low activity of clotting factor X (FX). Diagnosis may occur early in life, particularly in patients with a family history of the disorder or severe deficiency, or later in life for those with mild-moderate deficiency. Regardless of age at diagnosis, this disorder can significantly impact the lives of patients, as well as those of caregivers and/or family members. Alongside a wide historical array of HFXD treatments, including supportive care with blood transfusions, FX replacement with fresh frozen plasma or prothrombin complex concentrates, specific replacement has been made possible with the isolation and concentration of human plasma-derived FX for therapeutic use, offering the potential for a streamlined prophylactic regimen and improved quality of life and wellbeing. Two recent case studies describe the diagnosis and management of children with HFXD in India and the Philippines, both of whom were diagnosed in infancy following severe bleeding episodes. They share important similarities but highlight key differences in the experience of diagnosis and management of HFXD. Together they illustrate the lack of a specific target population subgroup for this rare but serious bleeding disorders, and the importance of checking FX levels (among other clotting factors) when prothrombin time (PT) and partial thromboplastin time (PTT) are prolonged.
Microarray analysis of microrna expression in peripheral blood mononuclear cells of patients with polymyositis and dermatomyositis
Authors: Shi Jia , Zhou Shuang , Zhao Jiuliang , Xu Dong , Huang Hui , Li Mengtao , Tian Xinping , He Linrong , Wu Chanyuan , Wang Qian , Zhao Yan , Zeng Xiaofeng 
Published: May 2024

Abstract

Background and Objectives
MicroRNAs (miRNAs) represent a new class of biomarkers in the context of connective tissue disorders. The miRNA expression profiles in peripheral blood mononuclear cells (PBMCs) of patients with polymyositis (PM) and dermatomyositis (DM) have not been fully elucidated. The objective is to investigate miRNAs expression profile in PBMCs of patients with PM/DM.

Methods
Microarray technology was used to identify differentially expressed miRNAs in PBMCs obtained from 6 untreated PM/DM patients and 3 healthy controls (HCs). TaqMan-based stem-loop real-time PCR detection was used for validation in a cohort of 34 PM/DM patients and 20 HCs.

Results
Microarray analysis revealed 38 differentially expressed miRNAs (24 up-regulated and 14 down-regulated) in PM/DM patients compared to HCs. Four miRNAs (miR-320a, miR-335-3p, miR-34a-5p and miR-454-3p) were chosen for real-time PCR validation. The expression of miR-34a-5p was significantly upregulated in PM/DM group (P < 0.05). In subgroup analysis, miR-34a-5p was significantly upregulated in interstitial lung disease (ILD) group and DM group (P < 0.001). The level of SIRT1, a validated target of miR-34a, was significantly lower in PBMCs of PM/DM patients compared with HCs.

Conclusions
MiR-34a-5p may potentially participate in the pathogenesis of PM/DM through SIRT1, and may serve as a potential new biomarker for PM/DM-ILD.
The Roles of Green Human Resources on Employees Eco-Friendly Behavior, Organizational Commitment, and Corporate’s Environmental Performance
Authors: Azmy Ahmad 
Published: May 2024

Abstract
This work analyzes the implementation of green human resources in a package printing company. It specifically examines the effect of green human resources on employees’ eco-friendly behavior, employees’ organizational commitment, and corporate environmental performance. The study object was a package printing company’s performance in promoting green business. This exploratory quantitative study involved 510 employees as the respondents. They have worked in the company for at least three years, graduated from senior high school, and were minimum at staff-level. Data were collected by distributing questionnaires through Google Form and analyzed using PLS-SEM. The study result showed that eco-friendly behavior positively affects employees’ organizational commitment and corporate environmental performance. Employees’ ecofriendly behavior positively affects the corporate environmental performance. Meanwhile, employees’ organizational commitment positively affects the employees’ eco-friendly behavior. Green human resources did not affect the employees’ eco-friendly behavior. This study concludes that green human resources could be achieved by enhancing employees’ organizational commitment. This commitment is proven to stimulate employees’ eco-friendly behavior, which supports the corporate’s environmental performance together with the green human resource. The company needs to set regulations or policies to improve the role of green HR in managing eco-friendly behaviors.
Examining the Relationships Between Transformational and Transactional Leadership and Employee Engagement During the Covid-19 Pandemic: The Moderating Effect of Employee Generations
Authors: Christopher Lee C. , Lim Hyoun Sook 
Published: May 2024

Abstract
This study examines the effects of various dimensions of transformational (i.e., charismatic leadership, intellectual stimulation, inspirational motivation, individual consideration) and transactional (i.e., contingent reward, and active management by exception) leadership on employee engagement during the COVID-19 pandemic. Additionally, this study explored moderating effects of generational differences (including Generation Z, Generation Y, Generation X) on the relationships between leadership and employee engagement. Based on a sample of 546 employees of three different generations, the findings of the multiple regression analysis showed mixed findngs. Implications and future directions for this study were discussed.
Exploring the Generation Z Travel Trends and Behavior
Authors: Popşa Roxana Elena 
Published: May 2024

Abstract
Tourism represents one of the sectors with the highest growth, and the upward trend of evolution implies the anticipation and adaptation to the changes in travel behavior. Currently, young travelers represent an important segment of the global tourism market. Generation Z decision-making processes are influenced both by the specific characteristics of the generation and by their travel habits. The travel motivations of the first generation born in the age of technology include socializing, acquiring unique experiences along with eco-friendly vacation options. During a trip, Generation Z visits museums, attends cultural or sports events and documents their choices by following travel influencers or social media posts. In these conditions, the paper aims to analyze the characteristics of the generation Z travel behavior and their perception of the future of travel. To achieve this objective, there will be a theoretical approach of generation Z coupled with secondary data analyses that will highlight the way young travelers organize their vacation.
Evaluating the Impact of Energy Price Shocks on Emerging Countries from the Non-Euro Area: A Macroeconomic Analysis
Authors: Horobeţ Alexandra , Dalu Maria-Alexandra , Negreanu Cristina 
Published: May 2024

Abstract
Exogenous shocks like the COVID-19 pandemic or the Russian conflict affected the global economy, but mostly emerging economies. Even though the critical moments have passed, the negative effects on the economy are still present in the current economic environment, characterized by high levels of uncertainty. Exogenous events, which have an uncertain likelihood of occurring, harm economies regardless of their development. In fact, a framework for unanticipated events is vital, as are steps to achieve low levels of national debt and increased authority stability. In this context, the objective of this paper is to examine the dynamic relationships between energy prices and certain macroeconomic variables, which were affected by the fact that the energy crisis triggered by the Russian-Ukrainian conflict overlapped with the accelerated transition to a green economy and the decarbonization process. The CEE countries are more vulnerable to the energy crisis, and their proximity to the front lines of military conflict can be an important fact to take into account. The research focuses on the Czech Republic, Hungary, Poland, and Romania. The empirical analysis was conducted on monthly frequency data and in order to present an effective method of modeling interactions between macroeconomic variables, the Bayesian technique was employed.