bluuebunny/crossref_metadata_2025_split huggingface dataset:
Coenzyme Q deficiency may predispose to sudden unexplained death via an increased risk of cardiac arrhythmia
Authors: Wang Shouyu , Haas Cordula , Wang Zhimin , Du Jianghua , Lin Zijie , Hong Guanghui , Li Liliang , Tao Ruiyang , Shen Yiwen , Neubauer Jacqueline 
Published: June 2024

AbstractCardiac arrhythmia is currently considered to be the direct cause of death in a majority of sudden unexplained death (SUD) cases, yet the genetic predisposition and corresponding endophenotypes contributing to SUD remain incompletely understood. In this study, we aimed to investigate the involvement of Coenzyme Q (CoQ) deficiency in SUD. First, we re-analyzed the exome sequencing data of 45 SUD and 151 sudden infant death syndrome (SIDS) cases from our previous studies, focusing on previously overlooked genetic variants in 44 human CoQ deficiency-related genes. A considerable proportion of the SUD (38%) and SIDS (37%) cases were found to harbor rare variants with likely functional effects. Subsequent burden testing, including all rare exonic and untranslated region variants identified in our case cohorts, further confirmed the existence of significant genetic burden. Based on the genetic findings, the influence of CoQ deficiency on electrophysiological and morphological properties was further examined in a mouse model. A significantly prolonged PR interval and an increased occurrence of atrioventricular block were observed in the 4-nitrobenzoate induced CoQ deficiency mouse group, suggesting that CoQ deficiency may predispose individuals to sudden death through an increased risk of cardiac arrhythmia. Overall, our findings suggest that CoQ deficiency-related genes should also be considered in the molecular autopsy of SUD.
Structure-preserving formulations for data-driven analysis of coupled multi-physics systems
Authors: Muixí Alba , González David , Chinesta Francisco , Cueto Elías 
Published: June 2024

AbstractWe develop a novel methodology for data-driven simulation of coupled multi-physics systems. The result of the method is a learned numerical integrator of the coupled system dynamics. In order to preserve the fundamental physics of the coupled systems, and thus preserve the geometrical properties of the governing equations—even if they may be completely unknown—we impose a port-metriplectic structure on the system evolution, i.e., a combination of a symplectic evolution for the system energy with a gradient flow for the entropy of each system, which can be exchanged through predefined ports. The resulting method guarantees by construction the satisfaction of the laws of thermodynamics for open systems, leading to accurate predictions of the future states of their dynamics. Examples are given for systems of varying complexity, based on synthetic as well as experimental data.
Predictors of outcome following an epidural steroid injection for disc-related sciatica: a Delphi consensus study
Authors: Stynes Siobhan , Foster Nadine , O’ Dowd John , Ostelo Raymond , Konstantinou Kika 
Published: June 2024

Abstract
Purpose
Trial data shows modest reductions in leg pain, disability and surgery avoidance following epidural steroid injections (ESI) for severe sciatica. Despite their common use, there is no clear evidence about which patients are more likely to benefit from ESI. The aim of this study was to generate consensus on potential predictors of outcome following ESI for disc-related sciatica.

Methods
A list of potential predictors of outcome was generated during a consensus meeting of seven experts. The items were subsequently presented in a two round on-line Delphi study to generate consensus among experts on which items are potential predictors of outcome. Consensus was defined as 70% agreement among participants.

Results
Sixty-one items were generated during the consensus meeting. Of ninety experts invited to participate in the on-line Delphi study, 44 (48%) and 33 (73%) took part in rounds one and two respectively. Twenty-eight additional items suggested by participants in round one were included in round two. Overall, 14 items reached consensus reflecting domains of health, medication use, pain intensity, psychosocial factors, imaging findings and type of injection.

Conclusion
Based on expert consensus, items that can be routinely collected in clinical practice were identified as potential predictors of outcomes following ESI.
Parents’ Perception of Risk in Play: Associations with Parent and Child Gender
Authors: Ryan Zoe J. , Stockill Helen , Nesbit Rachel J. , FitzGibbon Lily , Dodd Helen F. 
Published: June 2024

AbstractAllowing children the opportunity to take risks in their play may provide learning experiences that benefit children’s health and well-being. Parents’ perception of risk in children’s play may affect their behaviour and, in turn, their child’s risk-taking opportunities. This paper examines whether parent and child gender are associated with parents’ perceptions of risk in children’s play and whether any gender differences hold after controlling for parent anxiety. Data were collected from 88 parent dyads who were parents to preschool-aged children in England. Parent gender differences were found, with mothers perceiving greater risk in children’s risky play activities than fathers. Child gender was not significantly related to parents’ perception of risk. These findings are important for informing the development of programmes and advice designed to encourage parents to support their children’s outdoor, risky play. Specifically, they indicate that, for mothers in particular, support around perceiving risk and risk-reframing might help parents to give their child the opportunity to play in this way.
Evaluation of Frequency of CMV Replication and Disease Complications Reveals New Cellular Defects and a Time Dependent Pattern in CVID Patients
Authors: Marri Luca , Contini Paola , Ivaldi Federico , Schiavi Chiara , Magnani Ottavia , Vassallo Chiara , Guastalla Andrea , Traversone Noemi , Angelini Claudia , Del Zotto Genny , De Maria Andrea , De Palma Raffaele 
Published: June 2024

Abstract
Purpose
Common Variable Immunodeficiency (CVID) is characterized by hypogammaglobulinemia and failure of specific antibody production due to B-cell defects. However, studies have documented various T-cell abnormalities, potentially linked to viral complications. The frequency of Cytomegalovirus (CMV) replication in CVID cohorts is poorly studied. To address this gap in knowledge, we set up an observational study with the objectives of identifying CVID patients with active viraemia (CMV, Epstein-Barr virus (EBV)), evaluating potential correlations with immunophenotypic characteristics, clinical outcome, and the dynamic progression of clinical phenotypes over time.

Methods
31 CVID patients were retrospectively analysed according to viraemia, clinical and immunologic characteristics. 21 patients with non CVID humoral immunodeficiency were also evaluated as control.

Results
Active viral replication of CMV and/or EBV was observed in 25% of all patients. CMV replication was detected only in CVID patients (16%). CVID patients with active viral replication showed reduced HLA-DR+ NK counts when compared with CMV-DNA negative CVID patients. Viraemic patients had lower counts of LIN−DNAMbright and LIN−CD16+ inflammatory lymphoid precursors which correlated with NK-cell subsets. Analysis of the dynamic progression of CVID clinical phenotypes over time, showed that the initial infectious phenotype progressed to complicated phenotypes with time. All CMV viraemic patients had complicated disease.

Conclusion
Taken together, an impaired production of inflammatory precursors and NK activation is present in CVID patients with active viraemia. Since “Complicated” CVID occurs as a function of disease duration, there is need for an accurate evaluation of this aspect to improve classification and clinical management of CVID patients.
Comparison of drought indices in the analysis of temporal and spatial changes of climatic drought events: a case study in the Egirdir Lake basin (Isparta/Turkey)
Authors: Şener Erhan , Davraz Ayşen 
Published: June 2024

AbstractIn the Egirdir Lake Basin (Turkey), the six drought indices (i.e., SPI, PNI, DI, CZI, RAI and ZSI methods) were calculated for the three stations at 57 years between 1965 and 2022 on a 1-month and 1-year time scale. A positive correlation was determined between the drought index values calculated by the SPI, RAI, ZSI and CZI methods for three meteorological stations, even if the calculation method remains conceptually very different. Extremely dry periods and compatible results were determined in similar years according to all drought analysis methods for 1-year time scale at all stations. The RAI index gave the highest overall drought value (− 4.5) over the 1-year time scale compared to other indexes. In the analyzes of all drought methods, a very high correlation was determined for each station on a 1-year time scale. The correlation between the drought indices determined by different methods increased depending on the time scale. According to the drought analysis, it has been determined that there are dry periods for long periods, especially in recent years. It has been determined that this situation is compatible with the level drops in Egirdir Lake.
Evolutionary Game Dynamics with Environmental Feedback in a Network with Two Communities
Authors: Betz Katherine , Fu Feng , Masuda Naoki 
Published: June 2024

AbstractRecent developments of eco-evolutionary models have shown that evolving feedbacks between behavioral strategies and the environment of game interactions, leading to changes in the underlying payoff matrix, can impact the underlying population dynamics in various manners. We propose and analyze an eco-evolutionary game dynamics model on a network with two communities such that players interact with other players in the same community and those in the opposite community at different rates. In our model, we consider two-person matrix games with pairwise interactions occurring on individual edges and assume that the environmental state depends on edges rather than on nodes or being globally shared in the population. We analytically determine the equilibria and their stability under a symmetric population structure assumption, and we also numerically study the replicator dynamics of the general model. The model shows rich dynamical behavior, such as multiple transcritical bifurcations, multistability, and anti-synchronous oscillations. Our work offers insights into understanding how the presence of community structure impacts the eco-evolutionary dynamics within and between niches.
Modeling and mapping solar energy production with photovoltaic panels on Politecnico di Torino university campus
Authors: Usta Yasemin , Carioni Giovanni , Mutani Guglielmina 
Published: June 2024

AbstractEducational institutions have significant impacts on the society and environment they are inhabiting, and they can have a big role in influencing various development fields, including sustainability. The environmental sustainability of universities was critically analyzed recently. These bodies can contribute to the sustainability of cities due to their social role in shaping the future generations. The aim of this work is to analyze Urban Building Energy Modeling with a place-based approach using the open-source software QGIS in predicting energy production with photovoltaic solar technologies on the rooftops of the central university campus of Politecnico di Torino. This modeling can help in assessing the energy security and affordability of current and future sustainable scenarios considering their impact on climate change. This study evaluates the accuracy of urban scale QGIS-based energy modeling with a comparison of measured data available from the monitoring activity of LivingLab of Politecnico di Torino, the free tool PVGIS, and the web tools of ENEA. The QGIS modeling accuracy depends on the different precisions of the Digital Surface Model used to describe the built environment (i.e., 1 m or 5 m) and the climate input data (monthly and annual diffuse-to-global radiation and Linke turbidity factor). Moreover, this assessment can be used to map the results of new photovoltaic systems improving the energy and environmental performance of university campuses. The results of this work shed light on the significance of different input data for energy simulation tools at neighborhood-urban scale. The result shown accuracies in PV production of 10 to 37% with different spatial resolutions of the 3D built environment and of 14 to 15.2% for temporal resolution of solar irradiation variables.
Resonance assignments of cytochrome MtoD from the extracellular electron uptake pathway of sideroxydans lithotrophicus ES-1
Authors: Coelho Anaísa , Silva José M. , Cantini Francesca , Piccioli Mario , Louro Ricardo O. , Paquete Catarina M. 
Published: June 2024

AbstractThe contribution of Fe(II)-oxidizing bacteria to iron cycling in freshwater, groundwater, and marine environments has been widely recognized in recent years. These organisms perform extracellular electron transfer (EET), which constitutes the foundations of bioelectrochemical systems for the production of biofuels and bioenergy. It was proposed that the Gram-negative bacterium Sideroxydans lithotrophicus ES-1 oxidizes soluble ferrous Fe(II) at the surface of the cell and performs EET through the Mto redox pathway. This pathway is composed by the periplasmic monoheme cytochrome MtoD that is proposed to bridge electron transfer between the cell exterior and the cytoplasm. This makes its functional and structural characterization, as well as evaluating the interaction process with its physiological partners, essential for understanding the mechanisms underlying EET. Here, we report the complete assignment of the heme proton and carbon signals together with a near-complete assignment of 1H, 13C and 15N backbone and side chain resonances for the reduced, diamagnetic form of the protein. These data pave the way to identify and structurally map the molecular interaction regions between the cytochrome MtoD and its physiological redox partners, to explore the EET processes of S. lithotrophicus ES-1.
Disruptive behaviors in the classroom, a question of gender or of inadequate forms of coping?
Authors: Guil Rocío , Holgado-Herrero Magdalena , Gil-Olarte Paloma , González-Fernández Silvia , Costalat-Founeau Anne-Marie , Gómez-Molinero Rocío 
Published: June 2024

AbstractDisruptive behaviors in the classroom are a cause of concern for schools and educational researchers because of their impact on the rhythm of the class, harming students and teachers. The literature links the use of different coping strategies with disruptive behavior, with controversy regarding the frequency in which boys and girls engage in them, as well as a differential use of problem-focused versus emotion-focused strategies within the sexes. This study aimed to explore the relationships between gender, coping strategies, and adolescent disruptive behaviors and to identify possible idiosyncratic profiles of students regarding gender and the typology of disruptive behaviors. A sample of 382 high school students from the city of Algeciras (Cádiz, Spain) completed the Hormigo et al. (2003) Questionnaire of Perception of Conflict Behaviors and the Spanish adaptation of the Cano et al. (2007) Coping Strategies Inventory. The results showed that problem-focused coping strategies predicted a lower frequency of disruptive behaviors, whereas emotion-focused coping strategies increased the frequency of disruptive behaviors regardless of gender. Three differentiated profiles of students have also been identified: two groups of boys (adolescents who frequently committed all types of disruptive behaviors and boys who engage less frequently in disruptive behaviors) and a group of girls, more homogeneous, who resemble the group of disruptive boys showing more aggression towards teachers and school material and slightly disobedient, and differing from both boys groups regarding aggression among students.
Intracellular Macromolecular Crowding within Individual Stress Fibers Analyzed by Fluorescence Correlation Spectroscopy
Authors: Buenaventura Aria , Saito Takumi , Kanao Taiga , Matsunaga Daiki , Matsui Tsubasa S. , Deguchi Shinji 
Published: June 2024

Abstract
Introduction
The diffusion of cell components such as proteins is crucial to the function of all living cells. The abundance of macromolecules in cells is likely to cause a state of macromolecular crowding, but its effects on the extent of diffusion remain poorly understood.

Methods
Here we investigate the diffusion rate in three distinct locations in mesenchymal cell types, namely the open cytoplasm, the stress fibers in the open cytoplasm, and those below the nucleus using three kinds of biologically inert green fluorescent proteins (GFPs), namely a monomer, dimer, and trimer GFP. Fluorescence correlation spectroscopy (FCS) was used to determine the diffusion coefficients.

Results
We show that diffusion tends to be lowered on average in stress fibers and is significantly lower in those located below the nucleus. Our data suggest that the diffusive properties of GFPs, and potentially other molecules as well, are hindered by macromolecular crowding. However, although the size dependence on protein diffusion was also studied for monomer, dimer, and trimer GFPs, there was no significant difference in the diffusion rates among the GFPs of these sizes. These results could be attributed to the lack of significant change in protein size among the selected GFP multimers.

Conclusion
The data presented here would provide a basis for better understanding of the complex protein diffusion in the nonuniform cytoplasm, shedding light on cellular responses to mechanical stress, their local mechanical properties, and reduced turnover in senescent cells.
Geoconservation History of a Basalt Quarry – The Case of Mt. Wilkołak, Land of Extinct Volcanoes Geopark, SW Poland
Authors: Migoń Piotr , Pijet-Migoń Edyta 
Published: June 2024

AbstractMt. Wilkołak is one among many hills built of mid-Cenozoic basalts in SW Poland, within the Land of Extinct Volcanoes UNESCO Global Geopark. Appreciated as a recreational ground since the first half of the 19th century, it began to be quarried at the beginning of the 20th century. The quarry located on the western slope was soon abandoned, leaving impressive exposures of variously oriented basaltic columns due to thermal jointing and volcanic breccia. Briefly re-used after World War II, the quarry was definitely closed in 1956 and a small geological reserve was established in 1959. In the meantime, basalt exploitation developed at a much larger scale within the eastern slope, leading to the major conflict between conservation and industry, with frequent voices to delist the reserve and continue quarrying towards complete exhaustion of resources and removal of the entire hilltop. In addition, as a result of poor management of the reserve and uncontrolled vegetation growth its values significantly diminished. In the 21st century various actions initiated by the local community, supported by scientists, concurrent with incoming termination of quarrying, opened the debate about the future of Mt. Wilkołak and its quarries. Stone extraction ended in 2019, after a catastrophic collapse of one quarry wall, and rehabilitation works were executed in 2021–2023, aimed at the conversion of the locality into a place focused on geo-education and recreation. Opened in May 2023, it has various interpretation facilities and offers unprecedented insights into the internal structure of a volcanic plug. However, challenges related to site management, enhancement of educational content, and the future of the nature reserve remain.
Navigating tensions in climate change-related planned relocation
Authors: Gini Giovanna , Piggott-McKellar Annah , Wiegel Hanne , Neu Friedrich Nikolaus , Link Ann-Christine , Fry Claudia , Tabe Tammy , Adegun Olumuyiwa , Wade Cheikh Tidiane , Bower Erica Rose , Koeltzow Sarah , Harrington-Abrams Rachel , Jacobs Carolien , van der Geest Kees , Zivdar Narjes , Alaniz Ryan , Cherop Carolyne , Durand-Delacre David , Pill Melanie , Shekhar Himanshu , Yates Olivia , Khan Md Abdul Awal , Nansam-Aggrey Frank Kwesi , Grant Lauren , Nizar Danang Aditya , Owusu-Daaku Kwame Nitri , Preato Alberto , Stefancu Oana , Yee Merewalesi 
Published: June 2024

AbstractThe planned relocation of communities away from areas of climate-related risk has emerged as a critical strategy to adapt to the impacts of climate change. Empirical examples from around the world show, however, that such relocations often lead to poor outcomes for affected communities. To address this challenge, and contribute to developing guidelines for just and sustainable relocation processes, this paper calls attention to three fundamental tensions in planned relocation processes: (1) conceptualizations of risk and habitability; (2) community consultation and ownership; and (3) siloed policy frameworks and funding mechanisms. Drawing on the collective experience of 29 researchers, policymakers and practitioners from around the world working on planned relocations in the context of a changing climate, we provide strategies for collectively and collaboratively acknowledging and navigating these tensions among actors at all levels, to foster more equitable and sustainable relocation processes and outcomes.
Advancing the In-Class Dialogic Quality: Developing an Artificial Intelligence-Supported Framework for Classroom Dialogue Analysis
Authors: Li Xian , Han Guangxin , Fang Bei , He Juhou 
Published: June 2024

Abstract
The development of artificial intelligence (AI) significantly improves the effectiveness of classroom dialogue systems, but their integration into the learning environment remains challenging. To address this gap, this research presents a framework for automatic intelligent dialogue analysis, intending to promote high-quality classroom dialogue and facilitate teaching and learning. The proposed framework includes two main components: a dialogue-oriented interactive classroom and an artificial intelligence-powered analysis system. We present a synthesis of essential principles that ought to be adhered to in the dialogue-oriented interactive classroom, as viewed through the lens of three key domains: the environment, the community and the teaching–learning. The AI system will analyse the dialogues generated from the interactive classroom. The utilization of feedback obtained from the AI system assists educators who adjust their pedagogical strategies, consequently improving the quality of classroom dialogues. Elevated-quality dialogues will reciprocally boost the performance of the AI system, engendering a sustainable improvement for the entire framework. Moreover, we also propose “Guide of AI”, a union of classroom participants and experts, which serves as the bridge between the classroom and technology to guide the operation of AI system. For the validation of the framework, we conduct an empirical study that mainly investigates the effectiveness of processed essential principles and AI systems. We select 6 pre-service teachers who are randomly divided into three groups. Three groups have different levels of involvement in AI system and each teacher gives three lessons. We record and analyse all teaching dialogue records and also use questionnaires to obtain teachers’ attitudes. The results show that timely feedback from AI system can promote the improvement of dialogue quality, which demonstrates the effectiveness of AI dialogue analysis system. In addition, the proposed essential principles also show a constructive impact.