bluuebunny/crossref_metadata_2025_split huggingface dataset:
Beyond Slavery and Freedom?
Authors: Wimmler Jutta , Wiegmink Pia 
Published: May 2024

Abstract
This introductory essay to the special issue Beyond Slavery and Freedom? makes concrete suggestions how we might move beyond this binary and why we should do so. The introduction argues that the conceptual pair slavery/freedom is deeply entwined with narratives of modernity and progress and has shaped scholarship in very diverse fields. On the basis of empirical research from the Bonn Center for Dependency and Slavery Studies (BCDSS), we identify six possible pathways of thematically and methodologically moving beyond slavery/freedom that the contributions to the special issue address: 1) investigating forms of dependency that are not usually defined as slavery, 2) paying attention to semantic fields that are closely connected to this binary but not usually understood in relation to it, 3) highlighting the connection between (political, institutional) power and dependency, 4) engaging with post-slavery periods and experiences, 5) problematizing the challenges of identifying slavery in non-written records, and 6) underscoring the voice of actors.
Serving toward Release
Authors: Kloß Sinah T. 
Published: May 2024

Abstract
Autonomy is not universally considered the basis of agency in all cultural and historical contexts, nor is it always seen as a prerequisite to “freedom” and “liberation,” standing in conceptual opposite to coercion. In Caribbean Hindu contexts, the notion of service (sevā) as a form of (religious) work is aimed at decentering and dissolving the self for ultimate release from worldly suffering. Historically, regarding post-indenture Suriname and Guyana, some social actors understood godnas—the tattoos of especially senior Hindu women who identified as descendants of Indian indentured laborers—as a means of capacitating women and female bodies toward this goal by allowing them to conduct religious work. Some women with these tattoos considered godnas as voluntary and enabling. Their interpretations diverged from contemporary discourse, which links these tattoos to a presumed compulsory Hindu tradition that subjugated wives to husbands and in-laws. These varied assessments along a continuum of coercion and voluntariness highlight a continued focus on the conceptual binary that (un-)freedom obscures other relevant aspects of the (indentured) workers’ experiences. It runs the risk of reproducing Eurocentric notions of freedom, coercion, and work/labor, shrouding the pertinence of spiritual capital and (religious) rewards in analyses of coercive practices and structural violence.
Between Liberation and Recoercion
Authors: Smolarz Elena 
Published: May 2024

Abstract
Drawing on official imperial discourses in the Russian Empire and archival documents of the Orenburg Border Commission (1799–1856), the Russian imperial administrative institution subordinated to the Ministry of Foreign Affairs, this paper analyzes the ransoming, release, and reintegration of freed Russian subjects and shows how these processes and practices were inextricably linked to the Russian imperial concept of political belonging. In such a context, the concepts of freedom and liberation must be questioned; that is, we must determine the extent to which “freedom” can represent a universal value and is legally defined and thus dependent on sociopolitical situations and frameworks. To contribute to a more precise and multifaceted understanding of “freedom” and “dependency” as well as “freeing” and “enslavement,” this article examines the liberation and repatriation of enslaved Russian subjects in the Central Asian khanates of Khiva and Bukhara in the first half of the nineteenth century.
Establish Shared Visions and Support Productive Adaptations on All Levels
Authors: Prediger Susanne , Selter Christoph 
Published: May 2024

Abstract
Large-scale implementation programs for mathematics education innovations should combine several implementation strategies and span over several levels: the mathematics classroom level, the teacher professional development (PD) level, and the facilitator PD level, as well as over the systemic contexts on each of these levels. In this paper, we present the strategies and program architecture of the German nationwide 10-year implementation program QuaMath, which aims at developing the quality of mathematics classrooms and teacher PD in cooperation with the federal states, 400 PD facilitators, and, prospectively, 10000 schools. Given the spread of intended implementation and the depth of the targeted instructional innovations, we also outline the general philosophy of establishing shared visions with all stakeholders and support their productive adaptations at the same time. This philosophy also underpins the planned implementation design research in the program.
The impact sheet to this article can be accessed at 10.6084/m9.figshare.25507138.
Anthologies of Persian Poetry Inscribed in Indonesia: A Handlist of Rare Manuscripts
Authors: Daneshgar Majid 
Published: May 2024

Abstract
This article is about seven rare manuscripts copied in Indonesia from the 15th–19th centuries. They include Persian poetic collections and musical modes, occasionally mixed with Hindi and Turkic phrases. This handlist is an introduction to the reception and circulation of Persianate texts in the Malay-Indonesian world for about five hundred years.
Predictors of basic and instrumental activities of daily living among older adults with multiple chronic conditions
Authors: Jafari-Koulaee Azar , Mohammadi Eesa , Fox Mary T. , Rasekhi Aliakbar , Akha Ozra 
Published: May 2024

Abstract
Background
Understanding the predictors of functional status can be useful for improving modifiable predictors or identifying at-risk populations. Researchers have examined the predictors of functional status in older adults, but there has not been sufficient study in this field in older adults with multiple chronic conditions, especially in Iran. Consequently, the results of this body of research may not be generalizable to Iran. Therefore, this study was conducted to determine the predictors of functional status in Iranian older adults with multiple chronic conditions.

Methods
In this cross-sectional study, 118 Iranian older adults with multiple chronic conditions were recruited from December 2022 to September 2023. They were invited to respond to questionnaires inquiring about their demographic and health information, basic activities of daily living (BADL) and instrumental activities of daily living (IADL), depression and cognitive status. The predictors included age, gender, marital status, education, number of chronic conditions, and depression. Descriptive and analytical statistical tests (univariate and multiple regression analysis) were used to analyze the data.

Results
The majority of participants were married (63.9%) and women (59.3%). Based on the results of the multiple regression analysis, age (B=-0.04, P = 0.04), depression (B=-0.12, P = 0.04), and IADL (B = 0.46, P < 0.001) were significant predictors for functional status in terms of BADL. Also, marital status (B=-0.51, P = 0.05), numbers of chronic conditions (B=-0.61, P = 0.002), and BADL (B = 0.46, P < 0.001) were significant predictors for functional status in terms of IADL.

Conclusion
The findings support the predictive ability of age, marital status, number of chronic diseases, and depression for the functional status. Older adults with multiple chronic conditions who are older, single, depressed and with more chronic conditions number are more likely to have limitations in functional status. Therefore, nurses and other health care providers can benefit from the results of this study and identify and pay more attention to the high risk older adult population.
Triglyceride-glucose index as a potential predictor for in-hospital mortality in critically ill patients with intracerebral hemorrhage: a multicenter, case–control study
Authors: Yang Yang , Liang Shengru , Liu Jiangdong , Man Minghao , Si Yue , Jia Dengfeng , Li Jianwei , Tian Xiaoxi , Li Lihong 
Published: May 2024

Abstract
Background
The correlation between the triglyceride-glucose index (TyG) and the prognosis of ischemic stroke has been well established. This study aims to assess the influence of the TyG index on the clinical outcomes of critically ill individuals suffering from intracerebral hemorrhage (ICH).

Methods
Patients diagnosed with ICH were retrospectively retrieved from the Medical Information Mart for Intensive Care (MIMIC-IV) and the eICU Collaborative Research Database (eICU-CRD). Various statistical methods, including restricted cubic spline (RCS) regression, multivariable logistic regression, subgroup analysis, and sensitivity analysis, were employed to examine the relationship between the TyG index and the primary outcomes of ICH.

Results
A total of 791 patients from MIMIC-IV and 1,113 ones from eICU-CRD were analyzed. In MIMIC-IV, the in-hospital and ICU mortality rates were 14% and 10%, respectively, while in eICU-CRD, they were 16% and 8%. Results of the RCS regression revealed a consistent linear relationship between the TyG index and the risk of in-hospital and ICU mortality across the entire study population of both databases. Logistic regression analysis revealed a significant positive association between the TyG index and the likelihood of in-hospital and ICU death among ICH patients in both databases. Subgroup and sensitivity analysis further revealed an interaction between patients' age and the TyG index in relation to in-hospital and ICU mortality among ICH patients. Notably, for patients over 60 years old, the association between the TyG index and the risk of in-hospital and ICU mortality was more pronounced compared to the overall study population in both MIMIC-IV and eICU-CRD databases, suggesting a synergistic effect between old age (over 60 years) and the TyG index on the in-hospital and ICU mortality of patients with ICH.

Conclusions
This study established a positive correlation between the TyG index and the risk of in-hospital and ICU mortality in patients over 60 years who diagnosed with ICH, suggesting that the TyG index holds promise as an indicator for risk stratification in this patient population.
Associations of sleep disorders with serum neurofilament light chain levels in Parkinson’s disease
Authors: Qi Wan-Yi , Sun Yan , Guo Yun , Tan Lan 
Published: May 2024

Abstract
Background
Sleep disorders are a prevalent non-motor symptom of Parkinson’s disease (PD), although reliable biological markers are presently lacking.

Objectives
To explore the associations between sleep disorders and serum neurofilament light chain (NfL) levels in individuals with prodromal and early PD.

Methods
The study contained 1113 participants, including 585 early PD individuals, 353 prodromal PD individuals, and 175 healthy controls (HCs). The correlations between sleep disorders (including rapid eye movement sleep behavior disorder (RBD) and excessive daytime sleepiness (EDS)) and serum NfL levels were researched using multiple linear regression models and linear mixed-effects models. We further investigated the correlations between the rates of changes in daytime sleepiness and serum NfL levels using multiple linear regression models.

Results
In baseline analysis, early and prodromal PD individuals who manifested specific behaviors of RBD showed significantly higher levels of serum NfL. Specifically, early PD individuals who experienced nocturnal dream behaviors (β = 0.033; P = 0.042) and movements of arms or legs during sleep (β = 0.027; P = 0.049) showed significantly higher serum NfL levels. For prodromal PD individuals, serum NfL levels were significantly higher in individuals suffering from disturbed sleep (β = 0.038; P = 0.026). Our longitudinal findings support these baseline associations. Serum NfL levels showed an upward trend in early PD individuals who had a higher total RBDSQ score (β = 0.002; P = 0.011) or who were considered as probable RBD (β = 0.012; P = 0.009) or who exhibited behaviors on several sub-items of the RBDSQ. In addition, early PD individuals who had a high total ESS score (β = 0.001; P = 0.012) or who were regarded to have EDS (β = 0.013; P = 0.007) or who exhibited daytime sleepiness in several conditions had a trend toward higher serum NfL levels.

Conclusion
Sleep disorders correlate with higher serum NfL, suggesting a link to PD neuronal damage. Early identification of sleep disorders and NfL monitoring are pivotal in detecting at-risk PD patients promptly, allowing for timely intervention. Regular monitoring of NfL levels holds promise for tracking both sleep disorders and disease progression, potentially emerging as a biomarker for evaluating treatment outcomes.
Ethanol responsive lnc171 promotes migration and invasion of HCC cells via mir-873-5p/ZEB1 axis
Authors: Huang Shiping , Liao Zhouxiang , He Xiao , Song Zhenyu , Fang Xi , Wen Sha , Yang Lichao , Li Hui , Zhang Qi , Mo Wanling , Cheng Xiaojing , He Min , Huang Xuejing 
Published: May 2024

Abstract
Backgrounds
Long nonconding RNAs (lncRNAs) have been found to be a vital regulatory factor in the development process of human cancer, and could regarded as diagnostic or prognostic biomarkers for human cancers. Here, we aim to confirm the expression and molecular mechanism of RP11-171K16.5 (lnc171) in hepatocellular carcinoma (HCC).

Methods
Screening of differentially expressed lncRNAs by RNA sequencing. Expression level of gene was studied by quantitative real-time PCR (qRT-PCR). The effects of lnc171, mir-873-5p, and ethanol on migration and invasion activity of cells were studied used transwell assay, and luciferase reporter assay was used to confirm the binding site.

Results
RNA sequencing showed that lnc171 was markedly up-regulated in HCC. siRNA-mediated knockdown of lnc171 repressed the migration and invasion ability of HCC cells. Bioinformatic analysis, dual luciferase reporter assay, and qRT-PCR indicated that lnc171 interacted with mir-873-5p in HCC cells, and Zin-finger E-box binding homeobox (ZEB1) was a downstream target gene of mir-873-5p. In addition, lnc171 could enhance migration and invasion ability of HCC cells by up-regulating ZEB1 via sponging mir-873-5p. More interestingly, ethanol stimulation could up-regulate the increase of lnc171, thereby regulating the expression of competing endogenous RNA (ceRNA) network factors which lnc171 participated in HCC cells.

Conclusions
Our date demonstrates that lnc171 was a responsive factor of ethanol, and plays a vital role in development of HCC via binding of mir-873-5p.
The effectiveness of a brief intervention for intensive care unit patients with hazardous alcohol use: a randomized controlled trial
Authors: Nissilä Eliisa , Hynninen Marja , Jalkanen Ville , Kuitunen Anne , Bäcklund Minna , Inkinen Outi , Hästbacka Johanna 
Published: May 2024

Abstract
Background
Screening for hazardous alcohol use and performing brief interventions (BIs) are recommended to reduce alcohol-related negative health consequences. We aimed to compare the effectiveness (defined as an at least 10% absolute difference) of BI with usual care in reducing alcohol intake in intensive care unit survivors with history of hazardous alcohol use.

Methods
We used Alcohol Use Disorder Identification Test-Consumption (AUDIT-C) score to assess history of alcohol use.
Patients: Emergency admitted adult ICU patients in three Finnish university hospitals, with an AUDIT-C score > 5 (women), or > 6 (men). We randomized consenting eligible patients to receive a BI or treatment as usual (TAU).
Intervention: BI was delivered by the time of ICU discharge or shortly thereafter in the hospital ward.
Controls: Control patients received TAU.
Outcome: The primary outcome was self-reported alcohol consumption during the preceding week 6 and 12 months after randomization. Secondary outcomes were the change in AUDIT-C scores from baseline to 6 and 12 months, health-related quality of life, and mortality. The trial was terminated early due to slow recruitment during the pandemic.

Results
We randomized 234 patients to receive BI (N = 117) or TAU (N = 117). At 6 months, the median alcohol intake in the BI and TAU groups were 6.5 g (interquartile range [IQR] 0–141) and 0 g (0–72), respectively (p = 0.544). At 12 months, it was 24 g (0–146) and 0 g (0–96) in the BI and TAU groups, respectively (p = 0.157). Median change in AUDIT-C from baseline to 6 months was − 1 (− 4 to 0) and 2 (− 6 to 0), (p = 0.144) in the BI and TAU groups, and to 12 months − 3 (− 5 to − 1) and − 4 (− 7 to − 1), respectively (p = 0.187). In total, 4% (n = 5) of patients in the BI group and 11% (n = 13) of patients in the TAU group were abstinent at 6 months, and 10% (n = 12) and 15% (n = 17), respectively, at 12 months. No between-groups difference in mortality emerged.

Conclusion
As underpowered, our study cannot reject or confirm the hypothesis that a single BI early after critical illness is effective in reducing the amount of alcohol consumed compared to TAU. However, a considerable number in both groups reduced their alcohol consumption.
Trial registration: ClinicalTrials.gov (NCT03047577).
NANOG controls testicular germ cell tumour stemness through regulation of MIR9-2
Authors: Cardenas Ryan P , Zyoud Ahmad , McIntyre Alan , Alberio Ramiro , Mongan Nigel P , Allegrucci Cinzia 
Published: May 2024

Abstract
Background
Testicular germ cell tumours (TGCTs) represent a clinical challenge; they are most prevalent in young individuals and are triggered by molecular mechanisms that are not fully understood. The origin of TGCTs can be traced back to primordial germ cells that fail to mature during embryonic development. These cells express high levels of pluripotency factors, including the transcription factor NANOG which is highly expressed in TGCTs. Gain or amplification of the NANOG locus is common in advanced tumours, suggesting a key role for this master regulator of pluripotency in TGCT stemness and malignancy.

Methods
In this study, we analysed the expression of microRNAs (miRNAs) that are regulated by NANOG in TGCTs via integrated bioinformatic analyses of data from The Cancer Genome Atlas and NANOG chromatin immunoprecipitation in human embryonic stem cells. Through gain-of-function experiments, MIR9-2 was further investigated as a novel tumour suppressor regulated by NANOG. After transfection with MIR9-2 mimics, TGCT cells were analysed for cell proliferation, invasion, sensitivity to cisplatin, and gene expression signatures by RNA sequencing.

Results
For the first time, we identified 86 miRNAs regulated by NANOG in TGCTs. Among these, 37 miRNAs were differentially expressed in NANOG-high tumours, and they clustered TGCTs according to their subtypes. Binding of NANOG within 2 kb upstream of the MIR9-2 locus was associated with a negative regulation. Low expression of MIR9-2 was associated with tumour progression and MIR9-2-5p was found to play a role in the control of tumour stemness. A gain of function of MIR9-2-5p was associated with reduced proliferation, invasion, and sensitivity to cisplatin in both embryonal carcinoma and seminoma tumours. MIR9-2-5p expression in TGCT cells significantly reduced the expression of genes regulating pluripotency and cell division, consistent with its functional effect on reducing cancer stemness.

Conclusions
This study provides new molecular insights into the role of NANOG as a key determinant of pluripotency in TGCTs through the regulation of MIR9-2-5p, a novel epigenetic modulator of cancer stemness. Our data also highlight the potential negative feedback mediated by MIR9-2-5p on NANOG expression, which could be exploited as a therapeutic strategy for the treatment of TGCTs.
MSCs promote the efferocytosis of large peritoneal macrophages to eliminate ferroptotic monocytes/macrophages in the injured endometria
Authors: Wang Jiali , Li Jingman , Yin Lijie , Wang Xiuzhu , Dong Yue , Zhao Guangfeng , Shen Sunan , Hou Yayi 
Published: May 2024

Abstract
Background
Endometria are one of the important components of the uterus, which is located in the peritoneal cavity. Endometrial injury usually leads to intrauterine adhesions (IUA), accompanied by inflammation and cell death. We previously reported that both the endometrial ferroptosis was increased and monocytes/macrophages were involved in endometrial injury of IUA. Large peritoneal macrophages (LPMs) are recently reported to migrate into the injured tissues and phagocytose dead cells to repair the tissues. We previously demonstrated that mesenchymal stromal cells (MSCs) had made excellent progress in the repair of endometrial injury. However, it is unclear whether MSCs regulate the LPM efferocytosis against ferroptotic monocytes/macrophages in the injured endometria.

Methods
Here, endometrial injury in IUA mouse model was conducted by uterine curettage and LPS injection surgery and the samples were collected at different times to detect the changes of LPMs and ferroptotic monocytes/macrophages. We conducted LPMs depletion assay in vivo and LPMs and Erastin-induced ferroptotic THP-1 cells coculture systems in vitro to detect the LPM efferocytosis against ferroptotic monocytes/macrophages. The IUA model was treated with MSCs, and their effects on LPMs and endometrial repair were analyzed. Flow cytometry, western blotting, quantitative real-time PCR, immunohistochemical analysis, ELISA, and RNA-sequencing were performed.

Results
We found that LPMs migrated to the injured uteri in response to the damage in early phase (3 h), and sustained to a later stage (7 days). Astonishingly, we found that ferroptotic monocytes/macrophages were significantly increased in the injured uteri since 12 h after injury. Moreover, LPMs cocultured with Erastin-induced ferroptotic THP-1 cells in vitro, efferocytosis of LPMs against ferroptotic monocytes/macrophages was emerged. The mRNA expression profiles revealed that LPM efferocytosis against ferroptotic monocytes/macrophages was an induction of glycolysis program and depended on the PPARγ-HK2 pathway. Importantly, we validated that MSCs promoted the efferocytic capability and migration of LPMs to the injured uteri via secreting stanniocalcin-1 (STC-1).

Conclusion
The data collectively demonstrated first the roles of LPMs via removal of ferroptotic monocytes/macrophages and provided a novel mechanism of MSCs in repairing the endometrial injury.

Graphical Abstract
From papers to RDF-based integration of physicochemical data and adverse outcome pathways for nanomaterials
Authors: van Rijn Jeaphianne P. M. , Martens Marvin , Ammar Ammar , Cimpan Mihaela Roxana , Fessard Valerie , Hoet Peter , Jeliazkova Nina , Murugadoss Sivakumar , Vinković Vrček Ivana , Willighagen Egon L. 
Published: May 2024

Abstract
Adverse Outcome Pathways (AOPs) have been proposed to facilitate mechanistic understanding of interactions of chemicals/materials with biological systems. Each AOP starts with a molecular initiating event (MIE) and possibly ends with adverse outcome(s) (AOs) via a series of key events (KEs). So far, the interaction of engineered nanomaterials (ENMs) with biomolecules, biomembranes, cells, and biological structures, in general, is not yet fully elucidated. There is also a huge lack of information on which AOPs are ENMs-relevant or -specific, despite numerous published data on toxicological endpoints they trigger, such as oxidative stress and inflammation. We propose to integrate related data and knowledge recently collected. Our approach combines the annotation of nanomaterials and their MIEs with ontology annotation to demonstrate how we can then query AOPs and biological pathway information for these materials. We conclude that a FAIR (Findable, Accessible, Interoperable, Reusable) representation of the ENM-MIE knowledge simplifies integration with other knowledge.

Scientific contribution
This study introduces a new database linking nanomaterial stressors to the first known MIE or KE. Second, it presents a reproducible workflow to analyze and summarize this
knowledge. Third, this work extends the use of semantic web technologies to the field of nanoinformatics and nanosafety.