bluuebunny/crossref_metadata_2025_split huggingface dataset:
Intra‐abdominal fat in obese children
Authors: IWATA FUJIHIKO , TANIGUCHI KAZUO , YAMAZAKI HIROKI , HARA MITSUHIKO , OKADA TOMOO , HARADA KENSUKE 
Published: January 2011

AbstractWe investigated the distribution of abdominal fat accumulation in obese children to know whether a clustering of coronary risk factors was demonstrated in visceral fat obesity as reported in adults. The relative indicator of intra‐abdominal fat accumulation was obtained from computed tomography scans at the umbilicus level in 36 obese subjects (24 males, 12 females). There was no visceral fat obesity in this study by reported criteria. All metabolic variables except triglyceride did not correlate significantly with intra‐abdominal fat accumulation. We conclude that visceral fat obesity is a rare status and has no close relationship to coronary risk factors in childhood.
Pulse methylprednisolone therapy in children with membranoproliferative glomerulonephritis
Authors: EMRE SEVINÇ , ŞIRIN AYDAN , ALPAY HARIKA , TANMAN FAIK , UYSAL VELI , NAYIR AHMET , BILGE ILMAY 
Published: January 2011

AbstractThe effects of pulse methylprednisolone (PM) therapy were studied in 15 patients (aged 3–14 years) with biopsy proven membranoproliferative glomerulonephritis (MPGN). Patients were treated with intravenous PM 30 mg/kg (max 1 g) given over 30 min every other day for a mean of 9.8 days (3–15 days). Oral prednisolone therapy was continued at a dose of 1 mg/kg/24 h for 1 month and subsequently tapered off the following month. Eight patients had hematuria and six had medically controlled hypertension. Serum C3 levels were low in 11 patients and all of the patients had proteinuria. Following PM therapy proteinuria was significantly reduced from 2602.9 ± 1852.5 mg/24 h to 1871.2 ± 2090.8 mg/24 h (P < 0.05) and at final evaluation, proteinuria was 774.33 ± 1225.67 mg/24 h which was significantly lower than pre‐ and post‐PM therapy values (P < 0.05). Serum creatinine levels were high in five patients before PM therapy and remained high in one of the patients who progressed to end‐stage renal failure. After PM therapy, high serum creatinine levels normalized in three patients and was reduced, but still above normal, in one. One patient, with initially normal serum creatinine, had elevated levels afterwards. Nine of the patients were considered responsive and six non‐responsive according to our tentatively defined criteria. Mean follow‐up period was 27.4 ± 24.1 months (6–84 months). Three patients were lost for follow‐up, and 12 were re‐evaluated. At final evaluation, all of the patients except one with end‐stage renal failure had normal creatinine levels. There was no correlation between the clinical and laboratory features at onset and the outcome of the disease in the responder or non‐responder patients. Results of our study show that PM therapy reduced proteinuria and may affect renal function positively in patients with MPGN. However, a prospective controlled study with repeat biopsies is required to draw a conclusion.
Congenital hypothyroidism with delayed rise in serum TSH missed on newborn screening
Authors: ASAMI TADASHI , OTABE NAOKO , WAKABAYASHI MARIKO , KIKUCHI TOURU , UCHIYAMA MAKOTO 
Published: January 2011

AbstractWe report on a female patient with congenital hypothyroidism (CH) missed on a newborn screening test. She is now 10 years old with retarded development. The patient was born premature at 34 weeks of gestation with birth‐weight of 1515 g, and was judged to be normal in the screening programme of Niigata Prefecture. However, she gradually suffered from poor weight gain and retarded development with stridor at breathing. Serum thyroid stimulating hormone (TSH) levels were rechecked and showed high values with normal T3 and T4 levels. She was referred to our hospital at the age of 13 months. She was diagnosed as having CH (ectopic thyroid) with a delayed rise in blood TSH concentration, probably due to the prematurity of the hypothalamic‐pituitary‐thyroid axis. l‐thyroxine therapy brought a decline in TSH levels with partial improvement of her symptoms. Regardless of the result of newborn screening, infants with elevated serum TSH levels should be carefully examined for possible CH, even when T3, T4 and free T4 values are in the normal range.
Acute renal failure after exercise in a child with renal hypouricemia
Authors: FUJIEDA MIKIYA , YOKOYAMA WAKAKO , OISHI NAOBUMI , OKADA TAISUKE , KURASHIGE TAKANOBU , HAMADA GIBUN 
Published: January 2011

AbstractWe describe a 15 year old boy with renal hypouricemia who developed acute renal failure after a school athletics meeting, accompanied by appendicitis. During acute renal failure, the highest level of uric acid was 5.0 mg/dL, creatinine 7.9 mg/dL and urea nitrogen 58.6 mg/dL. After recovery, the serum uric acid fell to 0.9 mg/dL and the fractional excretion of uric acid (FEuA) exceeded the normal range. The probenecid and pyrazinamide tests showed that the patient had a total defect of uric acid reabsorption. This case suggested that strenuous exercise could be responsible for acute renal failure in patients with renal hypouricemia.
Herpes zoster in a normal child after varicella vaccination
Authors: MATSUBARA KOUSAKU , NIGAMI HIROYUKI , HARIGAYA HIDEKAZU , BABA KUNIZOU 
Published: January 2011

AbstractA healthy 5 year old girl developed herpes zoster in the dermatome supplied by the ophthalmic branch of the fifth cranial nerve 40 months after varicella vaccination. She was admitted to our hospital because of high fever and painful vesicular lesions over the left side of her forehead. She was treated successfully with systemic and topical acyclovir without developing herpetic keratoconjunctivitis. Our acute and convalescent phase evaluations showed that non‐specific cellular and humoral immunity was normal. This is the fourth case of herpes zoster developing in an immunocompetent child following vaccination. Unlike the previously reported cases, our patient required hospitalization mainly to prevent ocular involvement. The issue concerning whether the universal introduction of varicella vaccination of normal children will reduce the incidence of the subsequent occurrence of herpes zoster must await further studies involving longer follow‐up periods.
Changes in apolipoproteins during the acute phase of Kawasaki disease
Authors: KIM HIDEAKI , YAMAGUCHI HIDEO , INAMO KOJI , OKADA TOMOO , HARADA KENSUKE 
Published: January 2011

AbstactTo determine disturbances of lipid metabolism in patients with Kawasaki disease, we investigated changes in the serum levels of apolipoproteins and serum lipids. Results were as follows. Total serum cholesterol (TC) and high‐density lipoprotein cholesterol (HDL‐C) decreased during the early stage of Kawasaki disease. The apo A‐I and A‐II levels were low until the 2nd week of illness. Apo B decreased during the 1st week of illness, but rose slightly during the 2nd and 3rd weeks. The apo B/apo A‐I ratio and the apo B/TC ratio were high in the early stages of illness. The group of patients with coronary artery lesions showed low levels of TC and HDL‐C, and low levels of apo A‐I, A‐II and B during the early stages, compared with the group without coronary artery lesions. The apo B/TC ratio was significantly higher in the patients with coronary artery lesions during the 2nd week of illness.Our findings suggest an association between changes in serum lipids and apolipoproteins and coronary artery involvement in Kawasaki disease. These abnormalities may indicate the presence of early coronary arteriosclerosis.
Reduced immune response to hepatitis B vaccine in children with insulin dependent diabetes
Authors: FIÇICIOǦLU CAN , MIKLA SHARARE , MIDILLI KENAN , AYDIN AHMET , ÇAM HALIT , ERǦIN SEVGI 
Published: January 2011

AbstractTwenty‐four patients with moderately controlled insulin dependent diabetes with a duration of diabetes ranging from 2 to 10 years as well as 17 control subjects were vaccinated against hepatitis B virus using Gen Hevac B vaccine. The vaccine was injected 0.5 mL intramuscularly into the deltoid region on three separate occasions at intervals of 1 month. If subjects were still negative for anti‐hepatitis B surface antigen (HBs) or had inadequate antibody after the third injection, a fourth administration of vaccine was given 3 months later. The mean anti‐HBs titer was 243.3 ± 97.2 mi.u./mL in control subjects and 39.8 ± 53.2 in diabetic patients (P < 0.001). In the control group optimal protection was obtained in 100% of subjects, whereas 11 diabetic patients (45.8%) had low anti‐HBs titer (< 10 mi.u./mL). All of 11 diabetic patients showed adequate (> 10 mi.u./mL) anti‐HBs titer after the fourth dose of vaccine. In diabetic patients the most striking feature was the reduced CD4/CD8 ratio which was significantly lower (P < 0.001) than that of the control group. We conclude that diabetic children have an impaired immune response to hepatitis B vaccine. It is suggested that diabetic children should be vaccinated against hepatitis B virus with four injections instead of three.
Cartilage‐hair hypoplasia associated with IgG2 deficiency
Authors: KAWASAKI HIROHIDE , KOHDERA URARA , TANIUCHI SHOICHIRO , KOBAYASHI YOHNOSUKE 
Published: January 2011

AbstractWe report on a 1 year old boy with cartilage‐hair hypoplasia (CHH). He suffered from recurrent upper respiratory infections and short‐limbed dwarfism. As with most patients with CHH, he had impaired cellular immunity as determined by lymphocyte reactivity. In addition, he had a selective IgG2 deficiency. This combination of immunodeficiencies has not previously been reported for patients with CHH. His recurrent upper respiratory infections were likely to be associated with cellular immunodeficiency and IgG2 deficiency.
Overview of the Hanshin‐Awaji earthquake disaster
Authors: NAKAMURA HAJIME 
Published: January 2011

AbstractA severe earthquake struck the southern part of Hyogo prefecture at 5:46 a.m., 17 January 1995. The Kobe and Hanshin district, one of the greatest industrial and commercial areas in Japan, suffered many great disasters as a consequence of this earthquake. More than 5500 deaths, disconnection of electricity, water and gas, failure of telecommunications, collapse of highways and railroads, destruction of houses, apartment buildings and official buildings and fires in high‐density housing areas brought about the biggest disasters since the 1923 Tokyo quake.Many Japanese volunteers as well as foreign volunteers helped refugees after the earthquake. The actions of the refugees and their self‐possessed judgement, despite great inconveniences, in helping each other and saving aged and handicapped people, surprised many Japanese and foreigners alike.The preliminary reports in this issue describe the circumstances of child health and the medical care given after the disaster by the pediatricians who played an active role in the area affected by the earthquake.
Non‐conventional portosystemic shunts in children with extrahepatic portal vein obstruction
Authors: D'CRUZ ASHLEY J. , KAMATH PATRICK S. , RAMACHANDRA C. , JALIHAL ANAND 
Published: January 2011

AbstractPortal hypertension due to extrahepatic portal vein obstruction is ideally treated by the use of a selective shunt. In a four year period between July 1987 and June 1992, 50 surgical procedures were carried out in 48 children with portal hypertension‐related variceal hemorrhage. The portal, splenic, mesenteric, or coronary vein was not available for anastomosis in four children who, therefore, underwent non‐conventional shunts which are described here. There was no postoperative mortality. One patient had a repeat gastrointestinal hemorrhage, probably due to stenosis of the shunt and failure to ligate the coronary vein. No rebleeding occurred on follow‐up of at least 18 months. We conclude that in selected children requiring surgery for portal hypertension due to extrahepatic portal venous obstruction, a non‐conventional shunt may be used with beneficial results.
Standard and intermediate risk acute lymphoblastic leukemia in Poland: A report of the Polish Children's Leukemia/Lymphoma Study Group
Authors: RADWANSKA URSZULA , MICHALEWSKA DANUTA , KOLECKI PAWEL , ARMATA JERZY , BALWIERZ WALENTYNA , BOGUSLAWSKA‐JAWORSKA JANINA , CHYBICKA ALICJA , CYKLIS ROMANA , KOWALCZYK JERZY , OCHOCKA MARIA , PAWELEC KATARZYNA , ROKICKA‐MILEWSKA ROMA , SONTA‐JAKIMCZYK DANUTA , SLADKOWSKA GRAZYNA , ZELENAY ELZBIETA 
Published: January 2011

AbstractA total of 527 children with acute lymphoblastic leukaemia (ALL) from the most frequent risk groups: standard risk group (SRG) and intermediate risk group (IRG) were treated between 1987 and 1991 according to an intensified treatment program (based on the BFM protocol) including the use of an intermediate dose of methotrexate in the IRG. A comparison of the treatment results in this group from 513 children treated between 1981 and 1987 indicates that the chance for a 6 year event‐free survival has increased to 73% (previously 55%).
An infantile case of cytomegalovirus induced idiopathic thrombocytopenic purpura with predominant proliferation of CD10 positive lymphoblast in bone marrow
Authors: MIZUTANI KENICHI , AZUMA EIICHI , KOMADA YOSHIHIRO , ITO MASAHIRO , SAKURAI MINORU , HIRONAKA TAKESHI , HIRAI KANJI 
Published: January 2011

AbstractAn infant with cytomegalovirus infection (CMV) developed idiopathic thrombocytopenic purpura (ITP) at 4 months of age. A bone marrow (BM) aspiration showed a remarkable increase of immature megakaryocytes and prominent proliferation of lymphoblasts. Flow cytometric analysis of the bone marrow cells showed that the predominant cells in the lymphocyte cluster were of B‐lineage (CD19) with CD10 (common acute lymphoblastic leukemia antigen) positive. Virus study showed a high titer of CMV antibody. Cytomegalovirus DNA was detected by the polymerase chain reaction (PCR) method in urine, peripheral cells and marrow cells. Low‐grade fever, diarrhea and petechiae were accompanied by mild liver dysfunction. Complete remission was made with intravenous high‐dose immunoglobulin (IVIg) without progression to overt acute leukemia. The percentage of CD10+/CD19+ lymphocytes in bone marrow also diminished. We postulated that the proliferation of immature lymphocytes and megakaryocytes in bone marrow was caused by maturation arrest that might result from CMV infection.
A case with dicentric translocation between chromosome 9 and 18: Confirmation by fluorescent in situ hybridization on metaphase spread
Authors: ISOYAMA KEIICHI , IMAI MITSURU , ISHIKAWA AKIRA , FUJITA KAZUHIRO , SUTO YUMIKO , SHINOHARA TAMIKO 
Published: January 2011

AbstractA female child with dicentric translocation between chromosome 9 and chromosome 18 presented non‐specific minor anomalies with laryngomalacia. Chromosomal analyses were performed by the G‐banding method and a fluorescence in situ hybridization (FISH) technique with a specific probe for the centromeric region of chromosome 18 and the painting probe for the chromosomes 9 and 18. Her full karyotype was confirmed as 45, XX, tdic (9;18)(p24;p11). This is the first case of dicentric translocation between chromosomes 9 and 18. The FISH technique is an important tool in chromosome diagnostics.
A patient with WT syndrome and Castleman disease
Authors: VERGIN CANAN , ÇETINGÜL NAZAN , KAVAKLI KAAN , ÖZTOP SENAY , ÖZKINAY FERDA , ÇOKER MAHMUT , NIŞLI GÜNGÖR , SOYDAN SALIHA , BALIK EROL , AKAR ORHAN 
Published: January 2011

AbstractWT syndrome, an autosomal dominant condition, combines hematological abnormalities with mild lib defects. Anemia, pancytopenia, leukemia and lymphoma can occur at varying ages from childhood to middle age. Limb defects include ulnar and radial defects, bifid or hypoplastic thumbs and cutaneous syndactyly. Castleman disease is characterized by tumorous masses of lymphoid tissue showing plasma cell or hyaline vascular type changes in histological specimens.A 13 year old boy, diagnosed as WT syndrome with ulnar and radial deviation and 5th finger clinodactyly also had neutropenia, cervical and mediastinal lymphadenopathy. Histology of the cervical lymph node showed angiofollicular hyperplasia of the hyaline‐vascular type (Castleman disease). This interesting patient is reported because Castleman disease, together with WT syndrome has not been previously described.
Hypertrophic cardiomyopathy in Noonan syndrome
Authors: NISHIKAWA TOSHIO , ISHIYAMA SHIGERU , SHIMOJO TAKASHI , TAKEDA KAZUYO , KASAJIMA TAKKSHI , MOMMA KAZUO 
Published: January 2011

AbstractNoonan syndrome, a well‐known multiple congenital anomalies syndrome, is frequently accompanied by cardiovascular diseases including hypertrophic cardiomyopathy (HCM). The incidence of HCM in Noonan syndrome is approximately 20–30% and one‐third of cases reveal ventricular outflow obstruction. HCM in Noonan syndrome is occasionally associated with a congenital heart defect, whereas classic HCM seldom accompanies cardiac malformations. Asymmetric septal hypertrophy and symmetric septal hypertrophy (concentric hypertrophy) can be observed both in HCM with Noonan syndrome and in classic HCM. but apical hypertrophy has not been reported in Noonan syndrome yet, although it appears in classic HCM. Congestive heart failure is the major cause of death in patients with HCM in Noonan syndrome, but cases of sudden death have also been reported. The histopathologic findings of ventricular myocardial tissue in HCM with Noonan syndrome are similar to those in classic HCM.
Growth hormone treatment in Noonan syndrome
Authors: TANAKA TOSHIAKI 
Published: January 2011

AbstractGrowth responses to growth hormone (GH) treatment in Noonan syndrome are compared with those in short children with the other growth disorders. The responses in Noonan syndrome are much less than those in children with GH deficiency, a little less than those in children with non‐endocrine short stature and almost the same as those in children with Turner syndrome. As it is speculated that GH induces puberty earlier that expected in Noonan Syndrome, the efficiency of GH treatment for final height in Noonan syndrome is not promising.
Immunogenicity of the whole antigen and glycoprotein I of varicella‐zoster virus (VZV) and the VZV skin test antigen
Authors: KAWANO SHOJI , TERADA KIHEI , HIRAGA YUMIKO , MORITA TETSURO 
Published: January 2011

AbstractSpecific cellular immunity against the whole antigen and glycoprotein I (gp I) of varicella‐zoster virus (VZV) and the skin test antigen were determined for 13 healthy immune adults to compare the immunogenicity of these antigens using a lymphoproliferative assay. The stimulation index values (mean ± s.d.) were 16.4 ± 11.2 against the whole VZV antigen, 4.2 ± 2.9 against the VZV skin test antigen and 1.1 ±0.5 against gp I. The immunogenicity of the skin test antigen, which mainly contains gp III and gp IV, appears to be more favorable than that of gp I alone, but to be weaker than that of the whole VZV antigen.
Outbreak of acute glomerulonephritis in children: Observed association with the T1 subtype of group A streptococcal infection in Northern Kyushu, Japan
Authors: MASUYAMA TATSUO , ISHII EIICHI , MURAOKA KENJI , HONJO SATOSHI , YAMAGUCHI HIDETO , HARA TOSHIRO , SHIMAZAKI KOHJI , KOGA TATSUHIKO , MORIYA KAZUO , IDE MIKIKO , MIYAZAKI SUMIO 
Published: January 2011

AbstractGroup A streptococcal infection is associated with the occurrence of acute glomerulonephritis (AGN) and rheumatic fever (RF). A surveillance study in the Saga area, in northern Kyushu, Japan, showed a small variation in the reported number of group A streptococcal infections in the period 1988–94. However, of the AGN cases reported in this period, more than half were observed in 1992. In order to examine whether some change had occurred in the serotype distribution of Streptococcus pyogenes during the period, patients in the Saga area diagnosed as having group A streptococcal infection and patients with AGN or RF were analyzed. Serological T‐typing of S. pyogenes was carried out for patients with group A streptococcal infections, and the association between the occurrence of AGN or RF and the distribution of each different T subtype was analyzed. M‐typing of S. pyogenes was also carried out and the correlation between T and M types was examined. From 1988 to 1994, the annual number of patients with group A streptococcal infections in the Saga area showed a small variation, range 65–100 patients/year. Of the 42 patients with AGN and three with RF observed in this period, 27 with AGN (64%) and one with RF (33.3%) were detected in 1992. Only the T1 subtype increased in 1992; the other T subtypes showed little variation in incidence. The number of patients with the T1 subtype was significantly correlated with the occurrence of AGN by regression analysis (P < 0.01). Of the 170 subjects tested for both T and M subtypes, 44 of the 45 T1‐typed subjects had the M1 protein. Our epidemiological study suggested that the T1 subtype of streptococcal infection was associated with an outbreak of AGN in 1992 in the Saga area.
Evaluation of the peripheral circulatory status of the neonate during homeothermal adjustment by plethysmo‐time‐interval
Authors: OISHI MASAYA , NISHIDA HIROSHI , HOSHI JUN 
Published: January 2011

AbstractThe plethysmo‐time‐interval (PTI) is the time interval between the beginning of the QRS complex on an ECG and the upstroke of the pulse wave on a plethysmogram, as measured by pulse oximetry. In the present study, we investigated homeothermal acclimatization to the extra‐uterine environment in human neonates using the Coretemp thermometer and a pulse oximeter. Temperature was measured at three sites: the central deep temperature (CDT) on the upper sternum, the peripheral deep temperature (PDT) on the flat part of the left sole of the foot and the surface temperature (ST) at the side of the abdomen. After delivery, CDT and ST were higher than PDT. The difference between CDT and PDT was large at first, but gradually decreased. PDT, initially in the range of 32.4 ± 0.28°C, reached a stable value (34.4 ± 0.41 °C) at 2.5 h after delivery. PTI was prolonged in parallel with PDT. The difference between CDT and PDT probably reflected the contraction of skin vessels, particularly the arterioles, which occurs as a body defense mechanism against heat loss. As PTI was prolonged in parallel with PDT, we demonstrated objectively that this catch‐up phenomenon of PDT after delivery was affected by the increase in skin blood flow as a result of dilatation of peripheral arterioles. It was concluded that PTI can be used to evaluate the peripheral circulatory status of the neonate, even during homeothermal adjustment after birth, by applying a new principle of pulse oximetry that is widely used in neonatal intensive care units.
Change of immunological parameters in the clinical course of a myasthenia gravis patient with chronic graft‐versus‐host disease
Authors: HAYASHI MASATOSHI , MATSUDA OSAMU , ISHIDA YASUSHI , KIDA KAICHI 
Published: January 2011

AbstractThe change in immunological parameters was studied during the clinical course of a myasthenia gravis (MG) patient with chronic graft‐versus‐host disease (GVHD), which developed after bone marrow transplantation from an HLA‐identical donor. Anti‐acetylcholine receptor antibody gradually decreased in the patient treated with immunosuppressive agents, but was not detected in the donor. Lymphocyte numbers were low just before the onset of MG, increased abruptly within several days and then gradually decreased with treatment. The percentage of CD3+ and CD19+ lymphocytes was higher at onset than before, the percentage of CD4+ cells was higher at onset and gradually decreased with treatment, while CD8+ cells showed the lowest level just before onset and gradually increased during the clinical course. CD4+/CD45RA− cells also showed the highest levels at onset and a gradual decrease with treatment. Cellular, as well as humoral immune responses, might be associated with the pathogenesis of MG with chronic GVHD.