bluuebunny/crossref_metadata_2025_split huggingface dataset:
A protocol to determine the acceptability and feasibility of a pilot intervention emergency department virtual observation unit fall prevention program
Authors: Jones Abigail E. , Kennedy Maura , Hayden Emily M. , Ouchi Kei , N. Shankar Kalpana , Chary Anita , Li Angel , Loughlin Kara Mc , White Benjamin , Franco-Garcia Esteban , Dellheim Vanessa , Liu Shan W. 
Published: May 2024

Abstract
Background
As a third of all community dwellers aged 65+ fall each year, falls are common reasons for older adults to present to an Emergency Department (ED). Although EDs should assess patients’ multifactorial fall risks to prevent future fall-related injuries, this frequently does not occur. We describe our protocol to determine the feasibility, acceptability, and safety of a pilot ED Virtual Observation Unit (VOU) Falls program.

Methods
To ensure standardized conduct and reporting, the Standard Protocol Items for Intervention Trials (SPIRIT) guidelines will be used. The VOU is a program where patients are sent home from the ED but are part of a virtual observation unit in that they can call on-call ED physicians while they are being treated for conditions such as cellulitis, congestive heart failure, or pneumonia. A paramedic conducts daily visits with the patient and facilitates a telemedicine consult with an ED physician. VOU nursing staff conduct daily assessments of patients via telemedicine. The ED VOU Falls program is one of the VOU pathways and is a multi-component fall prevention program for fall patients who present after an ED visit. The paramedic conducts a home safety evaluation, a Timed Up and Go Test (TUG). During the VOU visit, the ED physician conducts a telemedicine visit, while the paramedic is visiting the home, to review patients' fall-risk-increasing drugs and their TUG test. We will determine feasibility by calculating rates of patient enrollment refusal, and adherence to fall-risk prevention recommendations using information from 3-month follow-up telephone calls, as well as qualitative interviews with the paramedics. We will determine the acceptability of the ED VOU Falls program based on patient and provider surveys using a Likert scale. We will ask VOU nursing staff to report any safety issues encountered while the patient is in the ED VOU Falls program (e.g., tripping hazards). We will use the chi-square test or Fisher’s exact test for categorical variables, Student’s t-test for continuous variables, and Mann-Whitney for nonparametric data. We will review interview transcripts and generate codes. Codes will then be extracted and organized into concepts to generate an overall theme following grounded theory methods. This is a pilot study; hence, results cannot be extrapolated. However, a definite trial would be the next step in the future to determine if such a program could be implemented as part of fall prevention interventions.

Discussion
This study will provide insights into the feasibility and acceptability of a novel ED VOU Falls program with the aim of ultimately decreasing falls. In the future, such a program could be implemented as part of fall prevention interventions.
Evaluation of MSCT severity scoring for prediction of mortality among patients with COVID-19
Authors: Mohammed Hossam Abd El-Moez , Mansour Tarek Mohamed M. , Abdalla Hytham , Gaber Mostafa A. , Badawy M. Sh. , El-baroudy Mohamed M. , AlAmir Ahmed Yousri , Abdelrazek Ghada M. , Elnabi Mona Gouda Maghrabi Abd 
Published: May 2024

Abstract
Background
Lung CT imaging may reveal COVID-19 abnormalities earlier than RTPCR. CT may be more sensitive than RT-PCR for diagnosing COVID-19-related pneumonia.

Aim
This study assesses the accuracy of multi-slice computed tomography (MSCT) grading in predicting COVID-19 mortality.

Methods
COVID-19 RT-PCR. For severity scores, all patients’ clinical examinations, history, and chest MSCT data were collected.

Results
According to the chest MSCT score, 102 (51.5%), 70 (35%), and 28 (14%) patients had mild, moderate, and severe illness. Out of the patients, 62 (31%) died, and 69% survived. Patients with severe MSCT scores showed a considerably greater mean age than other groups (P < 0.001). Moreover, this group had a considerably higher mean BMI (P < 0.001), and a majority (57.1%) were obese (P < 0.001). Compared to the mild group, the moderate and severe groups had significantly increased rates of diabetes, hypertension, and liver disease (P < 0.001). The moderate group had a greater rate of no comorbidities (P < 0.001). A severe MSCT score was linked to increased leucocytes, C-reactive protein, ESR, ferritin, d-dimer, HbA1c, and fasting blood sugar, as well as decreased mean lymphocytes (P < 0.001). Severe MSCT scores were linked to increased ICU admissions (P < 0.001) and increased demand for advanced mechanical ventilation and oxygen assistance (P < 0.001). A severe MSCT score was associated with the highest death rate, followed by a moderate MSCT score. Low mortality rates were observed in mild MSCT-scored patients (P < 0.001).

Conclusion
MSC T score severity is a reliable and noninvasive way to predict COVID-19 mortality
Analysis of the Trends and Influencing Factors for Postoperative Cough in Patients with Esophageal Cancer Based on Patient-Reported Outcomes
Authors: Sun Jie , Liang Rui , Zhang Qing , Liu Na , Zhu Qingmiao , Li Qi , Yu Dan , Yu Yuan , Qin Jianjun 
Published: May 2024

Abstract
Background
Cough is a common symptom that affects patients’ recovery and quality of life after esophagectomy. This study sought to investigate trends in postoperative cough and the factors that influence cough.

Methods
A total of 208 of 225 patients were enrolled in this study. The Mandarin Chinese version of the Leicester Cough Questionnaire was administered the day before surgery and at three time points (1 week, 1 month, and 3 months) after esophagectomy to assess patient-reported outcomes.

Results
All patients’ LCQ-MC scores after surgery were lower than presurgery (P < 0.05), with the lowest score found 1 week after esophagectomy. Factors associated with a cough 1 week after surgery included clinical stage of cancer (OR 0.782, 95% CI 0.647–0.944, P = 0.011), anastomotic position (OR 1.241, 95% CI 1.069–1.441, P = 0.005), duration of surgery (OR 0.759, 95% CI 0.577–0.998, P = 0.049), and subcarinal lymph node dissection (OR 0.682, 95% CI 0.563–0.825, P < 0.001). Factors associated with a cough one month after surgery included clinical stage (OR 0.782, 95% CI 0.650–0.940, P = 0.009), anastomotic position (OR 1.293, 95% CI 1.113–1.503, P = 0.001), and maintaining a semi-reclining position (OR 1.440, 95% CI 1.175–1.766, P < 0.001). Factors associated with a cough 3 months after surgery were clinical stage (OR 0.741, 95% CI 0.591–0.928, P = 0.009) and anastomotic position (OR 1.220, 95% CI 1.037–1.435, P = 0.016).

Conclusions
This study showed that the factors influencing postoperative cough differed over time following esophagectomy. These results may warrant prospective intervention to better manage patients undergoing surgery for esophageal cancer to prevent postoperative cough.
Long-term Health Outcomes of New Persistent Opioid Use After Gastrointestinal Cancer Surgery
Authors: Khalil Mujtaba , Woldesenbet Selamawit , Munir Muhammad Musaab , Khan Muhammad Muntazir Mehdi , Rashid Zayed , Altaf Abdullah , Katayama Erryk , Endo Yutaka , Dillhoff Mary , Tsai Susan , Pawlik Timothy M. 
Published: May 2024

Abstract
Background
New persistent opioid use (NPOU) after surgery has been identified as a common complication. This study sought to assess the long-term health outcomes among patients who experienced NPOU after gastrointestinal (GI) cancer surgery.

Methods
Patients who underwent surgery for hepato-pancreato-biliary and colorectal cancer between 2007 and 2019 were identified using the Surveillance, Epidemiology, and End Results (SEER)-Medicare-linked database. Mixed-effect multivariable logistic regression and Cox proportional hazard models were used to estimate the risk of mortality and hospital visits related to falls, respiratory events, or pain symptoms.

Results
Among 15,456 patients who underwent GI cancer surgery, 967(6.6%) experienced NPOU. Notably, the patients at risk for the development of NPOU were those with a history of substance abuse (odds ratio [OR], 1.45; 95% confidence interval [CI], 1.14–1.84), moderate social vulnerability (OR, 1.26; 95% CI, 1.06–1.50), an advanced disease stage (OR, 4.42; 95% CI, 3.51–5.82), or perioperative opioid use (OR, 3.07; 95% CI, 2.59–3.63. After control for competing risk factors, patients who experienced NPOU were more likely to visit a hospital for falls, respiratory events, or pain symptoms (OR, 1.45, 95% CI 1.18–1.78). Moreover, patients who experienced NPOU had a greater risk of death at 1 year (hazard ratio [HR], 2.15; 95% CI, 1.74–2.66).

Conclusion
Approximately 1 in 15 patients experienced NPOU after GI cancer surgery. NPOU was associated with an increased risk of subsequent hospital visits and higher mortality. Targeted interventions for individuals at higher risk for NPOU after surgery should be used to help mitigate the harmful effects of NPOU.
Practice Patterns and Outcomes Among Surgical Oncology Fellowship Graduates Performing Complex Cancer Surgery in the United States Across Different Career Stages
Authors: Tsilimigras Diamantis I. , Chatzipanagiotou Odysseas , Woldesenbet Selamawit , Endo Yutaka , Altaf Abdullah , Katayama Erryk , Pawlik Timothy M. 
Published: May 2024

Abstract
Background
Practice patterns and potential quality differences among surgical oncology fellowship graduates relative to years of independent practice have not been defined.

Methods
Medicare claims were used to identify patients who underwent esophagectomy, pancreatectomy, hepatectomy, or rectal resection for cancer between 2016 and 2021. Surgical oncology fellowship graduates were identified, and the association between years of independent practice, serious complications, and 90-day mortality was examined.

Results
Overall, 11,746 cancer operations (pancreatectomy [61.2%], hepatectomy [19.5%], rectal resection [13.7%], esophagectomy [5.6%]) were performed by 676 surgical oncology fellowship graduates (females: 17.7%). The operations were performed for 4147 patients (35.3%) by early-career surgeons (1–7 years), for 4104 patients (34.9%) by mid-career surgeons (8–14 years), and for 3495 patients (29.8%) by late-career surgeons (>15 years). The patients who had surgery by early-career surgeons were treated more frequently at a Midwestern (24.9% vs. 14.2%) than at a Northeastern institution (20.6% vs. 26.9%) compared with individuals treated by late-career surgeons (p < 0.05). Surgical oncologists had comparable risk-adjusted serious complications and 90-day mortality rates irrespective of career stage (early career [13.0% and 7.2%], mid-career [12.6% and 6.3%], late career [12.8% and 6.5%], respectively; all p > 0.05). Surgeon case-specific volume independently predicted serious complications across all career stages (high vs. low volume: early career [odds ratio {OR}, 0.80; 95% confidence interval {CI}, 0.65–0.98]; mid-career [OR, 0.81; 95% CI, 0.66–0.99]; late career [OR, 0.78; 95% CI, 0.62–0.97]).

Conclusion
Among surgical oncology fellowship graduates performing complex cancer surgery, rates of serious complications and 90-day mortality were comparable between the early-career and mid/late-career stages. Individual surgeon case-specific volume was strongly associated with postoperative outcomes irrespective of years of independent practice or career stage.
The Growing Importance of Social Skills for Labor Market Outcomes Across Education Groups
Authors: Kim Sun Hyung , Kwon Dohyoung 
Published: May 2024

Abstract
Using the 1979 and 1997 waves of the National Longitudinal Survey of Youth, this paper shows that the growing return to social skills documented by Deming (2017. “The Growing Importance of Social Skills in the Labor Market.” Quarterly Journal of Economics 132 (4): 1593–640) has been largely concentrated on college-educated workers, rather than on high school-educated workers. These findings are corroborated by the pronounced occupational sorting of college-educated workers into occupations requiring high levels of social skills. Moreover, the wage premium for college-educated workers employed in these occupations has increased markedly. Our empirical evidence provides one possible source of rising wage inequality within and between education levels.
Register and the dual nature of functional correspondence: accounting for text-linguistic variation between registers, within registers, and without registers
Authors: Egbert Jesse , Biber Douglas , Keller Daniel , Gracheva Marianna 
Published: May 2024

Abstract
During the past 20 years, corpus linguistic research on register variation has yielded important theoretical advances. The first part of this paper discusses these advances and the cumulative body of research that has produced them. In the second part of the paper, we focus on the goals of research on register variation. The traditional goal of the text-linguistic (TxtLx) approach to linguistic variation has been to describe registers and patterns of register variation: describing the linguistic and situational characteristics of registers. In this paper, we explore a related, but distinct, text-linguistic goal: to account for all linguistic variation among texts. Because the TxtLx framework assumes the importance of functional correspondence between linguistic characteristics and situational characteristics, it is reasonable to assume that in addition to register, we can use situational parameters coded continuously at the level of individual texts as additional predictors of text-linguistic variation. We describe the results of an empirical study to show that using both register categories and text-level situational parameters as predictors results in a more comprehensive and explanatory model of text-linguistic variation. In the conclusion we discuss the future of corpus-based register studies, focusing on unanswered questions related to theoretical claims about register.
A multifaceted approach to identifying and managing juvenile delinquency by integrating psycho-physiological indicators
Authors: Dattagupta Jayita , Banerjee Arnab , Maji Bithin Kumar , Chattopadhyay Prabal Kumar 
Published: May 2024

Abstract
To understand and treat juvenile delinquency, the study explores the relevance of psycho-physiological indicators. It also emphasizes the necessity for thorough research to minimize the gap existing between psycho-physiological measurements and conventional psychosocial components. The study focuses on the relevance of personality features, habituation, and autonomic arousal required to monitor the proper management of delinquent conduct. Through the integration of biological, psychological, and social elements into a multidimensional approach, researchers can uncover novel insights and create cutting-edge therapies for youths who are at risk of delinquent behavior. The study proposes to develop a comprehensive framework that considers biological antecedents in addition to conventional metrics to reach the root cause of delinquency; thereby drawing special attention to current literature and research that emphasizes the psycho-physiological correlates of delinquency. By examining the complex interactions between stress, physiology, emotions, behavior, and social structures, the study highlights the intricacy of delinquent conduct and the necessity for adopting a multifaceted strategy to fully address the problematic areas. Future research paths are emphasized, with a focus on the significance of longitudinal studies, moderating and mediating variables, and creative treatment techniques. By utilizing psycho-physiological markers and psychosocial traits, researchers can tailor intervention strategies to meet individual needs effectively. Early identification of psycho-physiological deficits in children is crucial for implementing successful behavior modification techniques and promoting the well-being of future generations. This is expected to help the government agencies to save time and public money.
Disaster Management in the Western Balkans Territory – Condition Analysis and Conceptualisation of the Cross-Border Cooperation Model
Authors: Trbojević Milovan , Radovanović Mirjana 
Published: May 2024

Abstract
The main objective of the paper is analysis and proposal of a concept for establishing an efficient system for disaster management in the Western Balkan countries. After the breakup of Yugoslavia (1992), there has been no effective system for managing emergency situations, while cross-border cooperation in this respect does not exist at all. The paper provides an overview of the situation in the field of emergency and crisis management in five countries of the region and a concept of promotion and cross-border cooperation in this field. The results of the research show that no country in the region has adequate emergency and disaster management system and that, regardless of the negative experiences, an efficient multilateral cooperation system has not been established so far in this field (there is neither regulatory framework nor proposals for the model of organization and for the procedures or technical mechanisms that would make the above possible). Therefore, the concept of establishing the Regional Center for Disaster Management in the Western Balkans territory (RCDM-WB) is proposed as a first step in handling disaster situations that arise from natural phenomena or technical and technological accidents. This is the first scientifically developed proposal of this kind for the above-mentioned region.
(p, q)-Compactness in spaces of holomorphic mappings
Authors: Jiménez-Vargas Antonio , Ruiz-Casternado David 
Published: May 2024

Abstract
Based on the concept of

(

p
,
q

)

\left(p,q)

-compact operator for

p
∈

[

1
,
∞

]

p\in \left[1,\infty ]

and

q
∈

[

1
,

p

*

]

q\in \left[1,{p}^{* }]

, we introduce and study the notion of

(

p
,
q

)

\left(p,q)

-compact holomorphic mapping between Banach spaces. We prove that the space formed by such mappings is a surjective

p
q
∕

(

p
+
q

)

pq/\left(p+q)

-Banach bounded-holomorphic ideal that can be generated by composition with the ideal of

(

p
,
q

)

\left(p,q)

-compact operators. In addition, we study Mujica’s linearization of such mappings, its relation with the

(

u

*

v

*

+
t

v

*

+
t

u

*

)

∕
t

u

*

v

*

\left({u}^{* }{v}^{* }+t{v}^{* }+t{u}^{* })/t{u}^{* }{v}^{* }

-Banach bounded-holomorphic composition ideal of the

(

t
,
u
,
v

)

\left(t,u,v)

-nuclear holomorphic mappings for

t
,
u
,
v
∈

[

1
,
∞

]

t,u,v\in \left[1,\infty ]

, its holomorphic transposition via the injective hull of the ideal of

(

p
,

q

*

,
1

)

\left(p,{q}^{* },1)

-nuclear operators, the Möbius invariance of

(

p
,
q

)

\left(p,q)

-compact holomorphic mappings on

D

{\mathbb{D}}

, and its full compact factorization through a compact holomorphic mapping, a

(

p
,
q

)

\left(p,q)

-compact operator, and a compact operator.
Produkt-Service-Systeme im Maschinen- und Anlagenbau
Authors: Künster Louisa , Humbeck Philipp , Gebhardt Marcel 
Published: May 2024

Abstract
Mechanical and plant engineering companies that have been focused primarily on product manufacturing in the past are recognizing the potential of a service-oriented business approach as they transform from technology providers to total solution providers. The increasing demand for holistic solutions is driving the development of product-service systems. This article closes a knowledge gap by developing a process model that enables the standardization and transferability of machine-specific product-service systems to entire machine portfolios.
Wirkmodell für zellulare Fahrerlose Transportsysteme
Authors: Mente Torben , Küster Benjamin , Stonis Malte , Overmeyer Ludger , Nyhuis Peter 
Published: May 2024

Abstract
A continuously growing number of product variants increases the demands on the flexibility of intralogistics transportation. One way to achieve greater flexibility is the use of cellular automated guided vehicles, which can be variably interconnected depending on the size of the product to be transported. This article explains the characteristics of cellular automated guided vehicles and the relationships between influencing variables of the cellular transport system and economic and logistical target variables.
Long-Term Protection from SARS-CoV-2 Variants in Mice by a Phase II Clinically Evaluated Original mRNA Vaccine Booster
Authors: Liu Jun , Sun Jing , Luo Liping , Tang Yanhong , Guo Hu , He Yiyun , Liu Qi , Yu Xuya , Huang Yumei , Zhang Siyuan , Zhu Airu , Dai Jun , Zhang Fan , Huang Tao , Zhao Jincun , Peng Yucai 
Published: May 2024

Objective:
The global coronavirus disease 2019 (COVID-19) pandemic was caused by SARS-CoV-2. The authors developed an mRNA vaccine (LVRNA009) that encoded the S protein of the Wuhan-Hu-1 strain and evaluated the long-term protection potential against SARS-CoV-2 variants.

Methods:
Mice were initially vaccinated with 2 doses of LVRNA009, then boosted 8 months later. The virus neutralization titers against SARS-CoV-2 variants and antigen-specific T cell responses of the mice were determined. These animals were also tested using viral challenge experiments. Moreover, a phase II clinical study was carried out in 420 healthy adults.

Results:
LVRNA009 vaccination induced neutralization antibodies and protected mice from SARS-CoV-2 original and Omicron BA.1.1 challenge 8 months post-boosting. A second booster dose of LVRNA009 further enhanced VNTs against Omicron variants. Clinical studies showed that LVRNA009 has good safety and immunogenicity profiles in humans.

Conclusion:
LVRNA009 could provide long-term protection against SARS-CoV-2 variants and confer better protection with a booster dose. These findings indicate that LVRNA009, a vaccine designed based on the original virus, might be effective in management of the COVID-19 pandemic.