bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prevalence of complementary medicine use in a phase 1 clinical trials program
Authors: Naing Aung , Stephen Saneese K. , Frenkel Moshe , Chandhasin Chandtip , Hong David S. , Lei Xiudong , Falchook Gerald , Wheler Jennifer J. , Fu Siqing , Kurzrock Razelle 
Published: April 2011

AbstractBACKGROUND:A key end point of early cancer clinical trials is the assessment of toxicities and their possible association with new experimental drugs. Therefore, the concurrent use of complementary and alternative medicine (CAM) in patients with advanced malignancies seen in a dedicated phase 1 clinic was evaluated.METHODS:An investigator‐designed survey was anonymously completed by patients seen in the phase 1 clinic. Pharmacologic CAM included any oral, topical, or intravenous agent, including vitamins, dietary supplements, and herbal products. Nonpharmacologic CAM included prayer, meditation, hypnosis, massage, and acupuncture.RESULTS:Of the 404 patients approached about completing the CAM survey, 394 (98%) agreed to respond, and 309 (78%) surveys were returned. Of those 309 patients, 162 (52%) used 1 or more CAM. Of the 162 CAM users, 77% utilized pharmacologic CAM, 71% used nonpharmacologic CAM, and 48% used both modalities. The most frequent CAM used were vitamins (70%), prayer (57%), and herbal products (26%). CAM utilization was not significantly associated with race, age, level of education, employment, or income level but was used more by women than men (P < .01). There was no statistically significant association between the use of CAM and quality of life as perceived by patients. Of the CAM users, 43% of patients had been using CAM for >5 years. Only 5% reported having side effects from using CAM, whereas 23% did not fully disclose their CAM use to their physicians.CONCLUSIONS:CAM usage is common in patients with advanced malignancies seen in a phase 1 clinic. Cancer 2011. © 2011 American Cancer Society.
Clinical course of adult patients with ependymoma
Authors: Armstrong Terri S. , Vera‐Bolanos Elizabeth , Gilbert Mark R. 
Published: April 2011

AbstractBACKGROUND:Ependymomas are a rare tumor in adults, and there are limited reports of the clinical course, treatment, and current health status of patients.METHODS:Patients with ependymoma completed an online survey regarding their diagnosis, treatment course, and current health status. Descriptive statistics were used to report the characteristics and degree of symptom severity. Correlations between demographic and clinical characteristics were explored with univariate analysis.RESULTS:One hundred eighteen adults participated, and there were more women (n = 68) than men (n = 50). The median age was 48 years (range, 22‐77 years). Fifty‐nine participants (48%) reported that they had not been able to work since their diagnosis, and 31% reported receiving disability benefits. Patients who had been treated for spine tumors had symptoms longer than those who had been treated for brain lesions (chi‐square statistic, 7.294; P = .026), and the majority had 3 symptoms before diagnosis. Most patients reported undergoing complete resection (brain lesions, 62%; spine tumors, 58%), and patients with spine tumors were less likely to have received additional treatment (chi‐square statistic, 9.687; P = .008). The majority had not had a recurrence and reported consulting a neurosurgeon for surveillance. Despite having stable disease and not receiving active treatment, most patients described moderate to severe symptoms, including fatigue (44%), numbness/tingling (39%), pain (36%), and disturbed sleep (34%) overall. Brain lesions were associated with altered vision (25%), difficulty concentrating (25%), weakness (19%), irritability (19%), difficulty speaking (19%), and understanding (17%); and spine lesions were associated with extremity weakness (55%), sexual dysfunction (48%), radiating pain (37%), and change in bowel pattern (35%).CONCLUSIONS:Treatment for adult patients with ependymoma is not standardized. Despite the low recurrence rate, patients reported significant symptoms and disability. Cancer 2011;. © 2011 American Cancer Society.
Scalable multicore architectures for long DNA sequence comparison
Authors: Sánchez Friman , Cabarcas Felipe , Ramirez Alex , Valero Mateo 
Published: April 2011

SUMMARYBiological sequence comparison is one of the most important tasks in Bioinformatics. Owing to the fast growth of databases that contain biological information, sequence comparison represents an important challenge for high‐performance computing, especially when very long sequences are compared, i.e. the complete genome of several organisms. The Smith–Waterman (SW) algorithm is an exact method based on dynamic programming to quantify local similarity between sequences. The inherent large parallelism of the algorithm makes it ideal for architectures supporting multiple dimensions of parallelism (TLP, DLP and ILP). Concurrently, there is a paradigm shift towards chip multiprocessors in computer architecture, which offer a huge amount of potential performance that can only be exploited efficiently if applications are effectively mapped and parallelized. In this work, we analyze how large‐scale biology sequence comparison takes advantage of the current and future multicore architectures. Our starting point is the performance analysis of the current multicore IBM Cell B.E. processor; we analyze two different SW implementations on the Cell B.E. Then, using simulation tools, we study the performance scalability when a many‐core architecture is used for performing long DNA sequence comparison. We investigate the efficient memory organization that delivers the maximum bandwidth with the minimum cost. Our results show that a heterogeneous architecture can be an efficient alternative to execute challenging bioinformatic workloads. Copyright © 2011 John Wiley & Sons, Ltd.
Probing the Functionalization of Gold Surfaces and Protein Adsorption by PM‐IRRAS
Authors: Marques de Oliveira Rodrigo , Ferreira Jacqueline , Santos Marcos J. L. , Faria Roberto M. , Oliveira Osvaldo N. 
Published: April 2011

AbstractThe control of morphology and coating of metal surfaces is essential for a number of organic electronic devices including photovoltaic cells and sensors. In this study, we monitor the functionalization of gold surfaces with 11‐mercaptoundecanoic acid (MUA, HS(CH2)10CO2H) and cysteamine, aiming at passivating the surfaces for application in surface plasmon resonance (SPR) biosensors. Using polarization‐modulated infrared reflection–absorption spectroscopy (PM‐IRRAS), cyclic voltammetry, atomic force microscopy and quartz crystal microbalance, we observed a time‐dependent organization process of the adsorbed MUA monolayer with alkyl chains perpendicular to the gold surface. Such optimized condition for surface passivation was obtained with a systematic search for experimental parameters leading to the lowest electrochemical signal of the functionalized gold electrode. The ability to build supramolecular architectures was also confirmed by detecting with PM‐IRRAS the adsorption of streptavidin on the MUA‐functionalized gold. As the approaches used for surface functionalization and its verification with PM‐IRRAS are generic, one may now envisage monitoring the fabrication of tailored electrodes for a variety of applications.
A cyclodissipativity characterization of power factor compensation of nonlinear loads under nonsinusoidal conditions
Authors: del Puerto‐Flores D. , Ortega R. , Scherpen J. M. A. 
Published: April 2011

SUMMARYRecently, it has been established that power factor (PF) improvement for nonlinear loads with nonsinusoidal source voltage is equivalent to imposing the property of cyclodissipativity to the source terminals. Using this framework, the classical capacitor and inductor compensators were interpreted in terms of energy equalization. The purpose of this brief note is to extend this approach in three directions. In the result reported in the literature, the supply rate is a function of the load, which is usually unknown, stymieing the applicability of the technique for compensator synthesis. Our first contribution is a new cyclodissipativity condition, which is also equivalent to PF improvement, but whose supply rate is now function of the compensator. Second, we consider general lossless linear compensators, instead of only capacitive or inductive compensators. As a result, we show that the PF is improved if and only if a certain equalization condition between the weighted powers of inductors and capacitors of the load is ensured. Finally, we exhibit the gap between the ideal compensator, namely the one that achieves unitary PF, and the aforementioned equalization condition. This result naturally leads to the formulation of a problem of optimization of the parameters of the compensator. Copyright © 2011 John Wiley & Sons, Ltd.
An optimized QoS scheme for IMS‐NEMO in heterogeneous networks
Authors: Liao Jianxin , Qi Qi , Li Tonghong , Cao Yufei , Zhu Xiaomin , Wang Jingyu 
Published: April 2011

SUMMARYThe network mobility (NEMO) is proposed to support the mobility management when users move as a whole. In IP Multimedia Subsystem (IMS), the individual Quality of Service (QoS) control for NEMO results in excessive signaling cost. On the other hand, current QoS schemes have two drawbacks: unawareness of the heterogeneous wireless environment and inefficient utilization of the reserved bandwidth. To solve these problems, we present a novel heterogeneous bandwidth sharing (HBS) scheme for QoS provision under IMS‐based NEMO (IMS‐NEMO). The HBS scheme selects the most suitable access network for each session and enables the new coming non‐real‐time sessions to share bandwidth with the Variable Bit Rate (VBR) coded media flows. The modeling and simulation results demonstrate that the HBS can satisfy users' QoS requirement and obtain a more efficient use of the scarce wireless bandwidth. Copyright © 2011 John Wiley & Sons, Ltd.
Fine‐needle aspiration cytology of orbital meningiomas
Authors: Agrawal Pallavi , Dey Pranab , Saikia Uma Nahar , Gupta Nalini , Radhika Srinivasan , Nijhawan Raje , Rajwanshi Arvind 
Published: April 2011

AbstractMeningiomas are benign tumors derived from arachnoid cells. Most commonly they arise within the cranial cavity, but they may arise extracranially in various anatomic sites. We present four cases of orbital meningiomas diagnosed on fine‐needle aspiration cytology (FNAC) and confirmed on histopathology. All the cases are presented with orbital mass. FNAC smears showed classical whorling and syncytial pattern of cells, withround to oval nucleus, inconspicuous nucleoli and one eachcase showed intranuclear inclusion and psammoma bodies. FNAC diagnosis of such lesions is difficult, because cytological features may mimic other soft tissue lesions located in orbital region. Awareness of this entity and its cytological appearance is important to allow correct diagnosis. Diagn. Cytopathol. 2012. © 2011 Wiley Periodicals, Inc.
Mullerianosis of the urinary bladder: Report of a case with diagnosis suggested in urine cytology and review of literature
Authors: Guan Hui , Rosenthal Dorothy L. , Erozan Yener S. 
Published: April 2011

AbstractMullerianosis of the urinary bladder is a rare entity characterized by the presence of an admixture of at least two types of mullerian tissue in the muscularis propria of the bladder. We report a case of mullerianosis of the urinary bladder in a 28‐year‐old nulliparous woman with no history of pelvic surgery or endometriosis, and the diagnosis of mullerianosis was suggested initially in urine cytopathology report. In this study, previously reported cases of mullerianosis of urinary bladder are reviewed, and differential diagnosis of endometrial‐like cells in the urine has been discussed. Fewer than 20 cases of mullerianosis of the urinary bladder have been reported in the literature, and only one of these cases had cytological description in a urine specimen. Most of patients were of reproductive age ranging from 28 to 53 years and had no previous history of pelvic surgery or Cesarean section. The clinical presentations frequently were abdominal/pelvic pain and dysuria/hematuria, which may or may not be associated with menstruation. Radiologic study revealed polypoid, mass‐like lesion ranging from 1 to 4.5 cm in size, predominantly involving the dome or posterior wall of the bladder. Histological sections showed two or more of the three related benign mullerian glandular epithelial proliferations—endometriosis, endosalpingiosis, and endocervicosis. Most of the patients have good prognosis with medical management. Diagn. Cytopathol. 2012. © 2011 Wiley Periodicals, Inc.
Follow‐up evaluation of radiation‐induced DNA damage in CSF disseminated high‐grade glioma using phospho‐histone H2AX antibody
Authors: Abe Hideyuki , Kawahara Akihiko , Sugita Yasuo , Yamaguchi Tomohiko , Terasaki Mizuhiko , Kage Masayoshi 
Published: April 2011

AbstractCytological examination of cerebrospinal fluid (CSF) is used not only for the diagnosis of spinal disease, but also to assess the postoperative effect of treatment. We experienced a case of high‐grade glioma in disseminated CSF, and retrospectively examined the clinical, pathological and cytological features. We further investigated radiation‐induced DNA damage in glioma cells using phospho‐Histone H2AX antibody. A five‐year‐old boy received a clinical diagnosis of optic nerve glioma, and was followed‐up for three months after chemotherapy. Magnetic resonance imaging was repeated, revealing abnormalities in other brain areas. The pathological diagnosis was anaplastic astrocytoma. CSF dissemination was detected, and increases in the number and mitosis of tumor cells were observed in CSF cytology. After radiotherapy the tumor cells in CSF decreased markedly. On cytomorphologic and immunocytochemical evaluation post‐irradiation, tumor cells showed vacuolation of both the nucleus and cytoplasm, degeneration of nuclear chromatin, and alteration of the phospho‐Histone H2AX expression, compared with tumor cells before the irradiation. CSF cytology is an effective means of evaluating DNA damage in tumor cells after irradiation, and may be useful in assessing the therapeutic response. Diagn. Cytopathol. 2011; © 2011 Wiley‐Liss, Inc.
Advanced glycation end products downregulate glucokinase in mice
Authors: Jung Hongsoo , Joo Jindeok , Jeon Yeonsu , Lee Junga , In Janghyeok , Kim Daewoo , Kang Eujin , Kim Yongshin , Lim Yonggul , Kang Jaehyeok , Choi Jinwoo 
Published: April 2011

AbstractBackgroundGlucokinase, the enzyme that catalyses the conversion of glucose to G‐6‐P, plays a key role in glucose metabolism. AGEs are implicated in diabetic complications. A previous study reported that AGEs decreased β‐cell function through inhibition of cytochrome c oxidase and adenosine triphosphate synthesis. This study investigated the effects of AGEs on glucokinase and islet function.MethodsSix‐month‐old male C57BL6 mice were divided into bovine serum albumin (BSA) and AGE‐BSA groups. BSA (200 µg/g) and AGE‐BSA (60 U/g) were administered intraperitoneally twice daily. After 2 weeks, serum AGE levels were measured, oral glucose tolerance test was performed, and insulin levels during the oral glucose tolerance test were determined. Glucokinase protein expression level and activity were measured in pancreatic islets.ResultsWe observed that the normal mice (C57/BL6) treated for 2 weeks with AGE‐BSA showed impaired glucose tolerance and decrease in acute insulin release. Glucokinase activity in islets from the AGE‐BSA‐treated mice was significantly inhibited and accompanied by blunted response of islets to high glucose stimulation. Moreover, in vitro experiments showed that glucokinase protein expression was decreased, its activity was inhibited, and islet function was decreased. GKA partially restored glucokinase activity and islet function caused by AGEs.ConclusionsWe concluded that AGEs inhibited glucokinase activity, leading to islet dysfunction in mouse pancreatic islets. Copyright © 2011 John Wiley & Sons, Ltd.
Reduction in insulin sensitivity following administration of the clinically used low‐dose pressor, norepinephrine
Authors: Khoury Nadia , McGill Janet B. 
Published: April 2011

AbstractBackgroundHyperglycaemia in acutely ill patients is well described and correcting this hyperglycaemia improves outcomes. It has been generally attributed to endogenous factors, specifically decreased secretion of insulin or increased secretion of anti‐insulin hormones, and cytokines, or both. Norepinephrine is the most commonly used vasopressor in critically ill patients. When titrated, it has anecdotally been found to cause wide swings in blood glucose levels. We tested the hypothesis that norepinephrine, a plausible exogenous, iatrogenic cause of hyperglycaemia, causes resistance to insulin action with the hyperinsulinaemic–euglycaemic clamp method.MethodsHyperinsulinaemic–euglycaemic (about 100 mg dL−1) clamps were performed before and during infusion of norepinephrine, in doses of 110 ng kg−1 min−1, which raised mean arterial pressure from 82 ± 7 to 94 ± 8 mmHg (p < 0.01) in 11 healthy adults.ResultsThe glucose infusion rate required to maintain euglycaemia during the clamps, a marker of whole‐body insulin sensitivity, decreased from 11.2 ± 3.7 mg kg−1 min−1 at baseline to 9.0 ± 2.6 mg kg−1 min−1 (p = 0.015) during the norepinephrine infusion. Steady‐state insulin and C‐peptide levels did not significantly change. Cortisol levels showed diurnal variation in the beginning and were also different at steady state.ConclusionsInfusion of pressor doses of norepinephrine causes resistance to insulin action in humans. Copyright © 2011 John Wiley & Sons, Ltd.
The role of Pax6 in forebrain development
Authors: Georgala Petrina A. , Carr Catherine B. , Price David J. 
Published: April 2011

AbstractPax6 encodes a highly conserved transcriptional regulator with two DNA‐binding motifs, a paired domain and a paired‐like homeodomain. Humans carrying PAX6 loss‐of‐function mutations suffer from abnormal development of the eyes (congenital aniridia) and brain. Small eye mice carrying Pax6 loss‐of‐function mutations provide a good model for these human conditions. Their analysis has demonstrated the critical importance of this transcription factor in multiple cell types and at several key stages of forebrain development. In the forebrain, Pax6 is critical for the establishment of the pallial–subpallial boundary, which separates dorsal (future cerebral cortex) and ventral (future striatum) telencephalic regions. Levels of Pax6 expression are critically important for cortical progenitor proliferation and its presence in a rostro‐lateralhigh to caudo‐mediallow gradient in the cortex is necessary to establish rostro‐lateral identities. Furthermore, axon guidance is disrupted in Pax6−/− mutants: the majority of thalamocortical axons fail to enter the ventral telencephalon and those that do are unable to innervate their cortical targets. The extent to which the effects of Pax6 later in development are secondary to its effects in early patterning and proliferation remains largely unknown. This is likely to be clarified by future studies on the molecular mechanisms of action of Pax6 and, in particular, the identification of its downstream target genes. Such studies should also help generate an increasingly coherent understanding of how this pleiotropic transcription factor becomes involved in so many facets of neural development. © 2011 Wiley Periodicals, Inc. Develop Neurobiol 71:690–709, 2011
Lowfat, a mammalian Lix1 homologue, regulates leg size and growth under the Dachsous/Fat signaling pathway during tissue regeneration†
Authors: Bando Tetsuya , Hamada Yoshimasa , Kurita Kazuki , Nakamura Taro , Mito Taro , Ohuchi Hideyo , Noji Sumihare 
Published: April 2011

AbstractIn the cricket Gryllus bimaculatus, missing distal parts of amputated legs are regenerated from blastemas based on positional information. The Dachsous/Fat (Ds/Ft) signaling pathway regulates blastema cell proliferation and positional information along the longitudinal axis during leg regeneration. Herein, we show that the Gryllus homologue of Lowfat (Gb'Lft), which modulates Ds/Ft signaling in Drosophila, is involved in leg regeneration. Gb'lft is expressed in regenerating legs, and RNAi against Gb'lft (Gb'lftRNAi) suppressed blastema cell hyperproliferation caused by Gb'ftRNAi or Gb'dsRNAi but enhanced that caused by Gb'kibraRNAi or Gb'wartsRNAi. In Gb'lftRNAi nymphs, missing parts of amputated legs were regenerated, but the length of the regenerated legs was shortened depending on the position of the amputation. Both normal and reversed intercalary regeneration occurred in Gb'lftRNAi nymphs, suggesting that Gb'Lft is involved in blastema cell proliferation and longitudinal leg regeneration under the Ds/Ft signaling pathway, but it is not required for intercalary regeneration. Developmental Dynamics 240:1440–1453, 2011. © 2011 Wiley‐Liss, Inc.
ET3/Ednrb2 signaling is critically involved in regulating melanophore migration in Xenopus
Authors: Kawasaki‐Nishihara Akiha , Nishihara Daisuke , Nakamura Harukazu , Yamamoto Hiroaki 
Published: April 2011

AbstractMelanoblasts are derived from neural crest cells (NCCs) and are the only NCCs that migrate through the dorsolateral pathway. However, how melanoblasts evolved to migrate through a pathway different from other NCCs is still unclear, because little is known about common molecular mechanisms of melanoblast migration that are conserved between species. Endothelin receptor B2 (Ednrb2) is required for avian melanoblasts to enter the dorsolateral pathway. Here, we show that Endothelin‐3 (ET3)/Ednrb2 signaling is also required for melanoblast migration in Xenopus laevis, although they migrate through the ventral pathway. In Xenopus, Ednrb2 is expressed by melanoblasts from pre‐migration stages and ET3 is expressed around their destinations, suggesting that ET3/Ednrb2 signaling may determine melanophore localization. Furthermore, melanoblast migration is interrupted by aberrant ET3/Ednrb2 signaling in vivo and their invasive ability is enhanced by ET3 in vitro. Our results suggest that ET3/Ednrb2 signaling is required for melanoblast migration in Ednrb2 gene‐conserved animals. Developmental Dynamics 240:1454–1466, 2011. © 2011 Wiley‐Liss, Inc.
Asymmetrically Dibridged Diiron(III) Complexes with Aminebis(phenoxide)‐Based Ligands for a Magnetostructural Study
Authors: Weyhermüller Thomas , Wagner Rita , Chaudhuri Phalguni 
Published: April 2011

AbstractThe ligands [N,N‐bis(3,5‐di‐tert‐butyl‐2‐hydroxybenzyl)aminoacetic acid] (H3L1), [N,N‐bis(2‐hydroxy‐3,5‐dimethylbenzyl)aminoacetic acid] (H3L2), [N,N‐bis(2‐hydroxy‐3,5‐dimethylbenzyl)‐N‐(2‐pyridylmethyl)amine] (H2L3) and [methylamino‐N,N‐bis(6‐tert‐butyl‐4‐methyl‐2‐methylenephenol)] (H2L4) were used to investigate their coordination properties toward FeIII. The ligand H3L1 yields mononuclear iron(III) complexes, complexes 1–3, whereas the asymmetrically dibridged diiron(III) complexes 4–8 were isolated with the ligands H3L2, H2L3 and H2L4. The complexes 1–8 have been structurally, magnetochemically (2–290 K) and spectroscopically investigated. Presumably as an effect of the sterically demanding tert‐butyl groups, only mononuclear FeIII complexes 1–3 were isolated with H3L1, whereas H3L2 bearing the less bulky methyl groups results in the diferric(III) complex 4. Complexes 4–8, containing two d5 high‐spin ferric centres, possess a diamagnetic St = 0 ground state that is attained through intramolecular antiferromagnetic coupling between the two paramagnetic centres. We have focused our investigation largely on the magnetostructural correlation of the asymmetrically dibridged (hydroxo, methoxo, acetate) diferric(III) complexes 4–8 and compared these to similar compounds reported in the literature. The spin‐exchange ability of the groups such as –OH, –OMe, –OR and –OPh is also compared.