bluuebunny/crossref_metadata_2025_split huggingface dataset:
Curcumin‐loaded nanoparticles effectively prevent T4‐induced oxidative stress in rat heart
Authors: Mishra Pallavi , Sahoo Dipak Kumar , Mohanty Chandana , Samanta Luna 
Published: June 2024

AbstractIn this study, we report the cardioprotective effect of the glycerol monooleate (GMO) based nanocurcumin in both in vitro and in vivo conditions under a hyperthyroid state. The heart is one of the primary target organs sensitive to the action of thyroid hormone, and slight variations in the thyroid hormone serum concentrations result in measurable changes in cardiac performance. Hyperthyroidism‐induced hypermetabolism is associated with oxidative stress and is an important mechanism responsible for the progression of heart failure. Curcumin has been known to play a protective role against oxidative stress‐related diseases like Alzheimer's, asthma, and aging due to its antioxidant properties. Nevertheless, its potent biological activity has been hindered due to its poor bioavailability. To overcome this drawback, a GMO‐based biodegradable nanoparticle (NP) formulation loaded with curcumin has been developed, and the protective effect of curcumin‐loaded NPs was compared against the native drug. Oxidative stress parameters like reactive oxygen species (ROS) release, change in mitochondrial membrane permeability, lipid peroxidation (LPx), lactate dehydrogenase (LDH) release, and the activity and protein expression of the endogenous antioxidant enzymes like superoxide dismutase, catalase (CAT) and glutathione peroxidase were evaluated. The results from in vitro showed that curcumin‐loaded NPs showed better DPPH and NO radical scavenging activity than native curcumin in a concentrations range of 2.5–20 µM. It was also observed that the nanoparticulate curcumin was comparatively more effective than native curcumin in protecting against ROS‐induced membrane damage by reducing LPx and LDH leakage at low concentrations of 5–10 µM. Further, curcumin NPs performed better in facilitating the activities of antioxidant enzymes under in vitro and in vivo conditions with respect to time and concentrations, resulting in reduced cellular ROS levels. In this scenario, we anticipate that curcumin‐loaded NPs can serve as a better antioxidant than its native counterpart in protecting the heart from oxidative stress‐related diseases.
Traumatic atlanto‐occipital dislocation with successfully bystander resuscitation after cardiopulmonary arrest: A case report
Authors: Inoue Takayuki , Morimoto Tadatsugu , Yoshihara Tomohito , Tsukamoto Masatsugu , Hirata Hirohito , Mawatari Masaaki 
Published: June 2024

Key Clinical MessageThis case report describes successful bystander cardiopulmonary resuscitation after a cardiopulmonary arrest due to a traffic accident, followed by early diagnosis and treatment of a traumatic atlanto‐occipital dislocation, resulting in successful community reintegration.
Fe‐Based Materials for Electrocatalytic Water Splitting: A Mini Review
Authors: Chatterjee Abhishikta , Chakraborty Priyanka , Kumar Bidyapati , Mandal Sourav , Dey Subrata K. 
Published: June 2024

AbstractIn the last few years, the development of effective electrocatalysts hold fascinating importance towards scalable green hydrogen (H2) and oxygen (O2) production has become an appealing area of research. A good number of iron‐based catalysts have been designed and synthesized which can mediate water splitting under mild conditions with minimum energy requirements. In this review, recent progress on iron‐based electrocatalysts focusing on Oxygen Evolution Reaction (OER), Hydrogen Evolution Reaction (HER), and Overall Water Splitting (OWS) are summarized. Tactical designing, targeted synthesis with electronic tuning, efficiency as well as durability are discussed here. The review is comprehensive and our target is to promote the development of highly efficient economical catalysts, to make their way from the laboratory to market by replacing noble metal‐based electrocatalysts.
Advances in the Development of Dual‐Atom Catalysts: Structural Characterization and Diversified Catalytic Applications
Authors: Zhang Liping , Liu Ce , Cui Xinjiang 
Published: June 2024

AbstractAtomically dispersed metal atoms on supports exhibit distinctive advantages in maximizing atomic utilization, which plays an indispensable role in the fabrication of cost‐effective catalysts. In particular, dual‐atom catalysts (DACs) containing dual active sites not only retain the merits of single‐atom catalysts (SACs), but also introduce diverse interactions between the two adjacent metal atoms, endowing them with superior catalytic performance and a broad range of applications. With the development of DACs, it is important to identify active sites and establish intrinsic catalytic mechanisms relationship. The general characterization methods for DACs are comprehensively summarized here, especially the structural nature of dual active sites is discussed in detail. Subsequently, the representative scientific research efforts in various applications including thermocatalysis, electrocatalysis, and photocatalysis are described, with emphasis on structure‐property relationships. Finally, a summary and some prospects for the future of advanced DACs are presented.
Feasibility of production fired bricks based lateritic soil at very low temperature
Authors: Sontia Metekong Jordan Valdès , Kaze Cyriaque Rodrigue , Kamseu Elie , Chinje Florence Uphie , Tatietse Thomas Tamo 
Published: June 2024

AbstractThe present project deals with the production of lateritic soil based bricks under different curing temperatures (28°C–150°C). A fraction of 10–30 wt% amount alkaline solution was added to improve the reactive phase content. The raw materials and hardened products were characterized using X‐ray diffraction (XRD), fourrier transform infrared spectroscopy (FTIR), mechanical properties and scanning electron microscope analysis. The results show that the addition of alkaline solution (30%) and the curing temperature (150°C) have a beneficial influence on physical properties (bulk density: 1.77 g/cm3, water absorption: 16.98%, and porosity: 30.13%) and mechanical performances (flexural: 6.61 MPa and compressive: 13.57 MPa). Compared with the code requirements for stabilized earth blocks, the compressive strength was higher than the minimum required. Microstructural investigations were also carried out to confirm the macrostructural properties. The above‐mentioned process appears to be a suitable candidate for engineering applications such as the stabilization of earth roads.
Design of pH‐universal electrocatalysts for hydrogen evolution reaction
Authors: Lin Jingwen , Wang Xu , Zhao Zhenyun , Chen Dongliang , Liu Rumin , Ye Zhizhen , Lu Bin , Hou Yang , Lu Jianguo 
Published: June 2024

AbstractThe path to searching for sustainable energy has never stopped since the depletion of fossil fuels can lead to serious environmental pollution and energy shortages. Using water electrolysis to produce hydrogen has been proven to be a prioritized approach for green resource production. It is highly crucial to explore inexpensive and high‐performance electrocatalysts for accelerating hydrogen evolution reaction (HER) and apply them to industrial cases on a large scale. Here, we summarize the different mechanisms of HER in different pH settings and review recent advances in non‐noble‐metal‐based electrocatalysts. Then, based on the previous efforts, we discuss several universal strategies for designing pH‐independent catalysts and show directions for the future design of pH‐universal catalysts.
Development of a Neopentyl 211At‐Labeled Activated Ester Providing In Vivo Stable 211At‐Labeled Antibodies for Targeted Alpha Therapy
Authors: Tada Masatoshi , Kaizuka Yuta , Kannaka Kento , Suzuki Hiroyuki , Joho Taiki , Takahashi Kazuhiro , Uehara Tomoya , Tanaka Hiroshi 
Published: June 2024

AbstractIn this study we developed a neopentyl 211At‐labeled activated ester that incorporates a triazole spacer and applied it to the synthesis of an 211At‐labeled cetuximab. The activated ester was synthesized via the nucleophilic 211At‐astatination of a neopentyl sulfonate carrying two long alkyl chains that serve as a lipid tag, which was followed by the hydrolysis of an acetal. Additionally, we developed a novel Resin‐Assisted Purification and Deprotection (RAPD) protocol involving a solid‐phase extraction of the protected 211At‐labeled compound from the mixture of the labeling reaction, hydrolysis of the acetal on the resin, and finally an elution of the 211At‐labeled activator from the resin. This method allows the synthesis of an 211At‐labeled activated ester with high purity through a simplified procedure that circumvents the need for HPLC purification. Using this 211At‐labeled activated ester, we efficiently synthesized 211At‐labeled cetuximab in 27±1 % radiochemical yield with 95 % radiochemical purity. This 211At‐activated ester demonstrated high reactivity, and enabled the completion of the reaction with the antibody within 10 min. In comparative biodistribution studies between 211At‐labeled cetuximab and the corresponding 125I‐labeled cetuximab in normal mice, both the thyroid and stomach showed radioactivity levels that were less than 1.0 % of the injected dose.
Structural Instability of NiFe‐Layered Double Hydroxide Nanosheets during Water Oxidation Operation
Authors: Meng Xiaoyi , Zhao Xiaohua 
Published: June 2024

AbstractNiFe‐layered double hydroxide (NiFe‐LDH) stands out as a promising electrocatalyst for the oxygen evolution reaction (OER), but the structural transformations under OER conditions are not well understood. The structural evolution of highly crystalline NiFe‐LDH on nickel foam during OER testing in 1 M KOH solution was analyzed using IR, Raman, XRD, XPS techniques, and DFT calculations. Instability of interlayer species within the NiFe‐LDH, including protons, anions, and water molecules, was found to cause the crystal structure to undergo expansion or contraction during OER operation, decreasing crystallinity and roughening the LDH surface. This dynamic structural evolution is crucial for determining OER activity, and it was observed that surface structural changes of the LDH, along with Fe content, jointly determined the degree of change in its OER activity. Our findings provide insights into designing active water‐splitting electrocatalysts and highlight the relationship between OER activity and the structure of NiFe‐LDH.
Time‐Dependent Extension of Grimme's Continuous Chirality Measure for Electronic Chirality Flips in Femto‐ and Attosecond Time Domains
Authors: Guo Yanrong , Haase Dietrich , Manz Jörn , Wang Huihui , Yang Yonggang 
Published: June 2024

AbstractGrimme's Continuous Chirality Measure (
) was developed for comparisons of the chirality of the electronic wave functions of molecules, typically in their ground states. For example,
,
and
for alanine, hydrogen‐peroxide, and for achiral molecules, respectively. Well‐designed laser pulses can excite achiral molecules from the electronic ground state to time‐dependent chiral superposition states, with chirality flips in the femto‐ or even attosecond (fs or as) time domains. Here we provide a time‐dependent extension
of Grimme's
for trailing the electronic chirality flips. As examples, we consider two laser driven electronic wavefunctions which represent flips between opposite electronic enantiomers of oriented NaK within
and
. The corresponding
vary respectively from
or from
to
, and back.
Monohydrides of the Group 13 Elements M=B, Al and Ga: Axial Bi‐Nucleophilicity and the Propensity to Form Both H−M⋅⋅⋅HX and M−H⋅⋅⋅HX Hydrogen Bonds (X=F, Cl, Br, I, CN, CCH, CP)
Authors: Alkorta Ibon , Legon Anthony C. 
Published: June 2024

AbstractEquilibrium dissociation energies De of the hydrogen‐bonded complexes HAl⋅⋅⋅HX and HGa⋅⋅⋅HX (X=F, Cl, Br, I, CN, CCH, and CP) were calculated ab initio at the CCSD(T)‐(F12c)/cc‐pVDZ−F12 level of theory. The gradients of graphs of De versus the electrophilicity EHX of the Lewis acids HX yielded the nucleophilicities NM−X of the Group 13 atoms M in these diatomic molecules. Molecular electrostatic surfaces potentials reveal that H−Al and H−Ga are bi‐nucleophilic and that the H ends of these H−M molecules are more nucleophilic than the M ends for M=Al and Ga, but not when M=boron. Therefore, the complexes M−H⋅⋅⋅HX were investigated using the same approach. It was concluded for M=Al and Ga that, for a given X, the M−H⋅⋅⋅HX complexes were more strongly bound than the corresponding H−M⋅⋅⋅HX complexes for both M=Al and Ga but the reverse order applies for M = boron. The effects of substituting the H atoms in the M−H molecules by F atoms and by methyl groups were investigated to measure the −I and +I inductive effects relative to H, respectively, on the nucleophilicities of the molecules M−H when M is acting as hydrogen‐bond acceptor in complexes H−M⋅⋅⋅H−X.
Examining the Past Injustices Suffered by Those in Corrections and the General Public: A New Therapeutic Approach May Be Necessary
Authors: Song Jacqueline Y. , Yu Lifan , Bonete Saray , Molinero Clara , Baskin Thomas W. , Huneke Daniel F. , Enright Robert D. 
Published: June 2024

ABSTRACTOne under‐researched area within corrections is the connection among (a) past adverse events, particularly in the form of injustices against those who now are incarcerated, (b) crimes committed and then (c) healing from the effects of that past adversity of injustice. Might those who have experienced severe injustices against them develop an anger or a hatred that then is displaced onto others, leading to arrest, conviction and imprisonment? This is not to imply that societies condone illegal behaviour but instead to assist in the healing from the adversity so that future crime is reduced. As a first step in this sequence, the study here examined in detail the kinds of injustices suffered by men in a maximum‐security correctional institution (N = 103) compared with men in a medium‐security environment (N = 37) and in the general public (N = 96). Findings indicated differences between those in the general public and those in the two correctional contexts. The latter two groups had (a) a higher severity of injustices against them (rated by a panel of researchers), (b) a more negative current impact that past injustices are having on them (also rated by a panel of researchers), (c) more reports that the injustices contributed to their choices to harm others, (d) more serious types of hurt (such as sexual abuse), (e) a stronger degree of self‐reported hurt and (f) more injustices from family members. Implications for correctional rehabilitation to reduce the negative psychological effects caused by the injustices of others are discussed.
The Still Elusive Role of Lightweight Doping in Carbon‐Based Electrocatalysts for the Selective Oxygen Reduction Reaction to Hydrogen Peroxide
Authors: Tuci Giulia , Rossin Andrea , Saki Zeinab , Caporaso Lucia , Liu Yuefeng , Centi Gabriele , Giambastiani Giuliano 
Published: June 2024

AbstractThe two‐electron electrocatalytic oxygen reduction reaction (ORR) to hydrogen peroxide (H2O2) is a valuable alternative to the more conventional and energy‐intensive anthraquinone process. From a circularity viewpoint, metal‐free catalysts constitute a sustainable alternative for the process. In particular, lightweight hetero‐doped C‐materials are cost‐effective and easily scalable samples that replace ‐ more and more frequently – the use of critical raw elements in the preparation of highly performing (electro)catalysts. Anyhow, their large‐scale exploitation in industrial processes still suffers from technical limits of samples upscale and reproducibility other than a still moderate comprehension of their action mechanism in the process. This concept article offers a comprehensive and exhaustive “journey” through the most representative lightweight hetero‐doped C‐based electrocatalysts and their performance in the 2e− ORR process. It provides an interpretation of phenomena at the triple‐phase interface of solid catalyst, liquid electrolyte and gaseous oxygen based on the doping‐driven generation of ideal electronic microenvironments at the catalyst surface.
A performance comparison of current controllers for grid‐tied photovoltaic microinverters
Authors: Jung Felipe , Pereira Thiago A. , Rech Thiago Fonseca , Coelho Roberto F. , Kirsten André Luís 
Published: June 2024

AbstractThe quality of the grid current injected by photovoltaic (PV) microinverters must comply with international standards. Hence, the controller and the converter must be designed to comply with grid current standards. Regarding the current control techniques, many control strategies can be applied to fulfill the quality requisites of a PV microinverter operation. Although more complex strategies may improve current, they require more computational effort and memory. This paper presents the design and implementation of five different discrete controllers of a grid‐tied microinverter. Experimental results of a comparison between the grid's current quality and the computational effort of the implemented control law are provided.
Deciphering the aging process through single‐cell cytometric technologies
Authors: Tam Lok Ming , Bushnell Timothy 
Published: June 2024

AbstractThe advent of single‐cell cytometric technologies, in conjunction with advances in single‐cell biology, has significantly propelled forward the field of geroscience, enhancing our comprehension of the mechanisms underlying age‐related diseases. Given that aging is a primary risk factor for numerous chronic health conditions, investigating the dynamic changes within the physiological landscape at the granularity of single cells is crucial for elucidating the molecular foundations of biological aging. Utilizing hallmarks of aging as a conceptual framework, we review current literature to delineate the progression of single‐cell cytometric techniques and their pivotal applications in the exploration of molecular alterations associated with aging. We next discuss recent advancements in single‐cell cytometry in terms of the development in instrument, software, and reagents, highlighting its promising and critical role in driving future breakthrough discoveries in aging research.
Design and Optimization of Dual Port Dielectric Resonator Based Frequency Tunable MIMO Antenna with Machine Learning Approach for 5G New Radio Application
Authors: Rai Jayant Kumar , Ranjan Pinku , Chowdhury Rakesh , Jamaluddin Mohd Haizal 
Published: June 2024

SummaryIn this article, a dual port Multiple Input Multiple Output (MIMO) cylindrical Dielectric Resonator (DR)‐based frequency tunable antenna with a machine learning (ML) approach for a 5G New Radio (NR) application is presented. According to the author's best knowledge, it is the first time‐frequency tunable MIMO hybrid DR with ML is reported. A dual port MIMO DRA is placed in the orthogonal configuration with the connected ground to obtain higher isolation
in the entire frequency range. The proposed dual port antenna provides a total spectrum (TS) and tuning range (TR) of 98.99% and 80.93%, respectively. The different MIMO parameters, Envelope Correlation Coefficient (ECC), Total Active Reflection Coefficient (TARC), and Diversity Gain (DG) are investigated and found within the acceptable limits. The optimization of the proposed dual port tunable antenna is done through the various ML algorithms, including Artificial Neural Network (ANN), K‐Nearest Neighbor (KNN), Decision Tree (DT), Random Forest (RF), and Extreme Gradient Boosting (XGB). The KNN ML algorithm provides more than 98% accuracy for predicting the S‐parameters in all configurations. Hence, the proposed antenna is suitable for 5G NR applications.
Vedolizumab in the treatment of Crohn's disease: A promising therapeutic approach
Authors: Zargar Abrar Ahmad 
Published: June 2024

AbstractCrohn's disease (CD) is a chronic and debilitating inflammatory bowel disease that affects millions of individuals worldwide. Despite the availability of various treatment options, a significant number of patients do not achieve remission or experience adverse effects with conventional therapies. Vedolizumab, a novel therapeutic agent, has emerged as a promising approach in the management of CD. Despite improvements in treatment choices, there is still a demand for medicines that are efficient and well‐tolerated. Vedolizumab, a monoclonal antibody targeting α4β7 integrin, has emerged as a promising therapeutic approach for the treatment of CD. The review aims to provide a summary of vedolizumab, current treatment options, impact of vedolizumab on the patient's quality of life, mechanism of action, clinical effectiveness, safety and efficacy of vedolizumab, potential side effects or risks associated with vedolizumab therapy, and potential predictors. Furthermore, we investigate limitations and challenges associated with vedolizumab and possible future developments and medical implications. This review provides a comprehensive examination of the present data supporting vedolizumab as a possible treatment option for CD, highlighting its benefits and outlining prospective directions for future study and clinical practice improvement.
Revealing hidden biodiversity: Novel insights on reptile and amphibian distribution in western Ecuador
Authors: Cruz‐García Keyko , Zapata‐Salvatierra Natalia , Sánchez‐Nivicela Juan C. , Chauca Nadia , Matecki Sascha , Perez‐Correa Julian 
Published: June 2024

AbstractWe present notable distributional updates for 14 species from western Ecuador (seven amphibians and seven reptiles). Our findings include the northernmost confirmed sighting of Pristimantis kuri and the southernmost documented record of Imantodes inornatus and Lepidoblepharis buchwaldi. Additionally, we document new records and notes on the distribution range of Agalychnis spurrelli, Hyloscirtus alytolylax, Engystomops montubio, Pristimantis muricatus, Pristimantis nyctophylax, Pristimantis walkeri, Chironius flavopictus, Chironius grandisquamis, Dendrophidion graciliverpa, Ninia schmidti, and Urotheca fulviceps. These observations significantly contribute to filling information gaps in our understanding of these species' distributions. The data, derived from samples collected across diverse forested areas in the western region of Ecuador (provinces of Bolívar, Cañar, Guayas, El Oro, and Los Ríos), provide valuable insights into the ecology and conservation of these species.
Variations in the phenological patterns of a caddisfly inhabiting the same mountain massifs: Life‐history differences in different altitudinal zones
Authors: Suzuki Hirohisa , Takenaka Masaki , Tojo Koji 
Published: June 2024

AbstractOrganisms inhabiting mountainous regions can experience large vertical environmental changes, and show different ecological characteristics between altitudes, thus facilitating allopatric fragmentation even in geographically close populations. This study compared the life‐history patterns of a species of limnephilid caddisfly, Asynarchus sachalinensis, in several genetically differentiated populations between alpine and sub‐alpine zones in a temperate mountainous region. We showed that in the sub‐alpine populations, larval development started earlier with increasing water temperature in spring, and adult emergence was also earlier. The occurrence of adults was extremely low in mid‐summer, probably due to summer diapause, followed by a larger number of ovary‐developed females in autumn. On the other hand, in the alpine zone, increasing water temperature was delayed compared to the sub‐alpine zone, and larval development occurred from early to mid‐summer. Adult emergence and ovary‐developed individuals were concentrated in mid‐summer. Hence, summer diapause was not observed. These results indicated life‐history differences between genetically differentiated populations at different altitudes. As the timing of adult occurrence and ovarian developmental patterns differ between populations at different altitudes, it is possible that reproductive isolation is facilitated or maintained between populations.