bluuebunny/crossref_metadata_2025_split huggingface dataset:
Management of an Infected Urachal Cyst during Pregnancy
Authors: Kotsuji Fumikazu , Hosokawa Kumiko , Takeuchi Yuzuru , Kamitani Naoyuki , Tominaga Toshiro 
Published: August 2010

AbstractAn infected urachal cyst complicating a pregnancy is extremely rare, but is considered to present a high risk to both the mother and the fetus. We treated a patient with an infected urachal cyst diagnosed at 29 weeks of gestation. A healthy infant was delivered by cesarean section at 37 weeks of gestation. The patient underwent excision of the unruptured cyst 37 days later. This is the first reported case of an infected urachal cyst complicating a pregnancy, that was diagnosed before rupture and was managed without serious sequelae for either the mother or the fetus. The diagnosis and management of the infected urachal cyst complicating the pregnancy is discussed.
Laparoscopic Surgery and DNA Analysis in Patients with XY Pure Gonadal Dysgenesis
Authors: Tsutsumi Osamu , Iida Taku , Taketani Yuji 
Published: August 2010

AbstractThe sex‐determining region on the Y chromosome (SRY) encodes a gene that has many of the properties expected of the testis‐determining factor. The XY pure gonadal dysgenesis is characterized by streak gonads in phenotypic females who lack the somatic abnormalities and short stature associated with Turner's syndrome. Abnormalities within the SRY have been described in these patients. However, we have experienced several patients with short stature whose SRY are apparently normal. The DNA sequencing of the SRY gene showed a 100% nucleotide sequence identity with the reported cloned sequence. Sex reversal in two of the present cases may be due to mutation at a locus other than SRY in the sex determining pathway, a gene potentially involved in the determination of human constitution. The risk of developing malignancy in the dysgenetic gonads has been reported to be 25%, dictating early prophylactic removal of the streaks. Laparoscopic surgery is recommended because of the amount of the surgery and the rapid postoperative recovery of the patient.
Enhanced Magnetic Resonance Imaging in Monitoring of Conservative Treatment of Cervical Pregnancy
Authors: Takashima Masaki , Yamasaki Mineo , Fujita Ichiro , Ohashi Masanobu , Matsuo Hiroya , Mochizuki Matsuto , Kitagaki Hajime , Kono Michio 
Published: August 2010

AbstractWe report on case of cervical pregnancy successfully treated by two 5‐day courses of etoposide, embryocide with the injection of KCl, the injection of methotrexate into the placenta, and cervical curettage. We evaluated the effects of these treatments by measuring urinary human chorionic gonadotropin (hCG) titers and serial hCGβ‐ carboxy‐terminal peptide (CTP) levels. Moreover, we used ultrasonography and magnetic resonance imaging (MRI) enhanced by gadolinium‐diethylenetriamine‐ pentaacetic acid (Gd‐DTPA) to diagnose and to evaluate the blood supply to the trophoblast. The beneficial outcomes suggest that Gd‐DTPA‐enhanced MRI is useful in detecting the blood supply to the trophoblast, in order to avoid the massive bleeding that results from conservative treatments. This is the first report of the usefulness of Gd‐DTPA‐enhanced MRI for the successful conservative treatment of cervical pregnancy.
A Randomized Study Comparing Suture with Non‐Suture Cold‐Knife Conization
Authors: Tangtrakul Somsak , Srisupundit Somkeart , Linasmita Vasant , Bullangpoti Sunchai , Israngura Nathapong , Wilailak Sarikapan , Panijayanusondthi Orapin 
Published: August 2010

AbstractObjective: To compare the short‐term outcome of cold‐knife conization between suture and non‐suture (with Monsel's solution pack) methods.Methods: Between February, 1990 and March, 1992, 142 patients underwent cold‐knife conization were randomly allocated into 2 groups. The hemostasis was done by suture in one group and by Monsel's solution pack without suture in the other group. The patients' and cone specimens' characteristics as well as short‐term outcome were recorded and compared using Chi‐square test, Fisher exact test and t‐ test where appropriate.Results: The patients' characteristics, cone size, and histologic diagnosis of both groups were comparable. The non‐suture group had shorter operative time (10.69 ± 7.86 vs. 20.04 ± 6.99 minutes) and lesser late hemorrhage (2.9 vs. 15.9%) than the suture group (p < 0.05). There was no statistical difference in the operative blood loss.Conclusion: The non‐suture method of conization should replace the traditional suture method
The Chromosome Complement of Human Uncleaved Oocytes
Authors: Kumar Rachana M. , Khuranna Ashok 
Published: August 2010

AbstractObjective: Investigation of human oocyte chromosomes that fail to fertilize may provide data essential to the assessment of reproductive failure. In view of this, 121 uncleaved human oocytes were analyzed cytogenetically to assess the type and frequency of chromosomal abnormality.Methods: Oocyte recovery was done from patients undergoing in vitro fertilization (IVE) procedures. Then, these oocytes were preincubated and inseminated in vitro. Karyotyping was attempted in 121 oocytes lacking signs fertilization 50 h after insemination.Results: Sixty‐nine oocytes were adequately karyotyped. The overall frequency of chromosomal aberration was 47.6%. Amongst these, 34.8% were aneuploidy, the frequency of which was significantly higher (p < 0.05) in patients > 35 years of age. Diploidy and hyperploidy was noted in 7.2% and 2.8% respectively. Translocation were noted in 2.8% and in 18.8% of human oocytes sperm chromosome condensation appeared prematurely in the G1 phase. No correlation was a found between specific chromosomal aberrations and type of fertility, stimulation treatment or gonadotrophin levels.Conclusion: The high rate of chromosomal disorders (47.6%) in human oocytes may contribute significantly towards their failure to fertilize in vitro.
Pregnancy, Labor and Delivery in a Woman with a Damaged Spinal Cord
Authors: Yaginuma Yuji , Kawamura Mitsuhiro , Ishikawa Mutsuo 
Published: August 2010

AbstractWe report here a case involving the pregnancy, labor and delivery of a woman with a damaged spinal cord. In our case, even though the cord was damaged below the Th11, continuous epidural anesthesia was needed to prevent autonomic hyperreflexia. The patient's and infant's subsequent courses were normal.
Sociobiological Risk Factors for Spontaneous Abortion in Malaysia
Authors: Tan Niap H. , Yahya Aziz , Adeeb Nafisah 
Published: August 2010

AbstractObjective: To evaluate the risk factors of spontaneous abortion.Methods: A case‐control study was conducted by interviewing 350 women who were admitted to the university gynaecological unit for spontaneous abortion and 350 women who delivered normally at the university obstetric unit. Odds ratios, as the estimators of relative risks, were calculated.Results: The relative risk for spontaneous abortion among women in the age‐group 30 to 39 years was 1.61 and among women above 40 years of age was 3.68 when compared to those below 30 years of age. In relation to career women, the relative risk of spontaneous abortion for housewives was 0.45. Ethnic group, parity, subfertility, previous induced abortion, ectopic pregnancy, contraception and menarcheal age did not influence the risk of spontaneous abortion.Conclusion: Increasing age and a woman's career are significant risk factors of spontaneous abortion.
The Vaginal Radical Operation of Cervical Cancer
Authors: Lichtenegger W. 
Published: August 2010

AbstractChoosing the surgical technique for the cervix carcinoma — vaginal or abdominal — it is particularly necessary to take into account the lymphatic spread of the cervix. As it is not possible to realize a lymphadenectomy in a vaginal procedure, it has to be found a preoperative diagnostic method which enables very surely the exclusion of lymph node involvement.In summary of the facts stated up to now, one can conclude as follows:1. The FIGO‐classification is too subjective.2. There is a significant correlation between tumor volume and lymph node involvement.3. The tumor markers — as e.g. PCNA, p53, c‐neu, EGF, β1 Integrin etc.— show no correlation with the lymph node involvement.4. Only MRI allows an exact preoperative measurement of the tumor volume.5. On account of the above mentioned results, it seems to be possible to extend the indication for the vaginal radical surgery on cases with a small tumor volume.
Perinatal Database in Germany
Authors: Brockerhoff Peter G. , Knapstein Paul G. 
Published: August 2010

AbstractBy collecting standardized data from up to 600,000 deliveries per year in Germany a nation‐wide database has been established in recent years enabling not only regional and overregional quality control, but also the scientific analysis of rare maternal and fetal complication. During the observation period of 10 years the understanding of perinatal risk factors has considerably improved and the perinatal mortality has declined from 9.4 to 6.4 (per 1,000 deliveries).From the huge amount of calculations typical results are presented.
Prevalence of Hemoglobin S and β‐Thalassemia in Northern Jordan*
Authors: Sunna Elias I. , Gharaibeh Nayef S. , Knapp Dona D. , Bashir Nabil A. 
Published: August 2010

AbstractObjective: The aim of this study was to determine the incidence of HbS and β‐thalassemia in the Northern Jordan.Study Design: The investigation targeted 3 areas of Northern Jordan. Blood samples from 2,290 volunteers were evaluated to determine the prevalence of HbS and β‐thalassemia by preparing a hemolysate for cellulose acetate electrophoresis. An additional 568 newborn samples were collected from the umbilical and analyzed for the presence of HbS using electrophoresis.Results: The overall prevalence of HbS and β‐thalassemia was 4.45% and 5.93%, respectively. The incidence of sickle cell trait in the newborn sample was 3.17%. The prevalence of both HbS and β‐thalassemia was higher in the Al‐Gor area in comparison to Ajloun and Irbid.Conclusion: A better understanding of the demographics of these diseases has the potential to aid in the more efficient utilization of health care resources and improved planning and provision of health care services.
Mixed Gonadal Dysgenesis with Gonadoblastoma in a Female with Y Chromosome: Case Report
Authors: Sadi Al Muktafi , Toda Takayoshi , Kiyuna Masaya , Miyagi Hiroko 
Published: August 2010

AbstractA young female with primary amenorrhea and male karyotype (46/XY) is reported. Physical examination and clinical investigation of the patient suggested mixed gonadal dysgenesis (MGD). After gonadectomy, a tumor was found on the left side and histologically diagnosed gonadoblastoma. Postoperative decreased level of testosterone and estradiol reflected the activities of the tumor.
Fetal and Neonatal Haemodilution Associated with Multiple Placental Chorioangioma: Case Report
Authors: Montan Sven , Anandakumar Chinnaiya , Joseph Roy , Arulkumaran Sabaratnam , Ng Soon‐Chye , Ratnam Shan S. 
Published: August 2010

AbstractA pregnancy with polyhydramnios and abnormal antepartum fetal heart rate pattern was found to have multiple placental haemangiomas. Multiple placental haemangiomas can give rise to fetal cardiac failure due to a hyperdynamic circulation or fetal anaemia either due to haemodilution or possibly destruction of blood cells in the chorioangioma. Whether fluid restriction with or without diuretics or blood transfusion is the correct form of treatment of neonatal cardiac failure in such a case is discussed.
Landry‐Guillain‐Barre‐Strohl Syndrome in Pregnancy
Authors: Yaginuma Yuji , Kawamura Mitsuhiro , Ishikawa Mutsuo 
Published: August 2010

AbstractWe report here a case of Landry‐Guillain‐Barre‐Strohl syndrome (LGBSs) in pregnancy. The patient had rubella viral infection, and the patient's inspiratory ability rapidly weakened. In the end, aggressive plasmapheresis prevented the need for respiratory support and the inherent risk it poses in terms of maternal morbidity and mortality.
In vitro Fertilization of in vitro Matured Oocytes Obtained from the Follicles without hCG Exposure for Prevention of Severe Ovarian Hyperstimulation Syndrome: A Case Report
Authors: Kodama Hideya , Fukuda Jun , Karube Hiroko , Matsui Toshihiko , Shimizu Yasushi , Tanaka Toshinobu 
Published: August 2010

AbstractWe aspirated ovarian follicles of an infertile patient who encountered a great risk of ovarian hyperstimulation (OHSS) during her ovulation‐induction cycle, which had been stimulated with gonadotropins, in order to avoid OHSS without interrupting the treatment. If this action were to yield a considerable number of immature oocytes, some of which were to achieve in vitro maturation and subsequent fertilization, this method could be an alternative to conventional ovulation‐induction methods for patients who repeatedly present imminent signs of hyperstimulation. However, the number of oocytes collected from the patient was disappointingly low, even though a large number of follicles were thoroughly aspirated. One of these oocytes was matured in vitro in a medium containing 30% follicular fluid and granulosa cells of mature follicles, fertilized, cryopreserved, and transferred in a later artificial cycle; but pregnancy was not achieved. A low number of recovered oocytes from patients in this situation might be a factor that greatly limits the clinical applications of this method.
Use of Intravenous Adenosine Triphosphate (ATP) to Terminate Supraventricular Tachycardia in a Pregnant Woman with Wolff‐Parkinson‐White Syndrome
Authors: Kanai Makoto , Shimizu Motohiko , Shiozawa Tanri , Ashida Takashi , Sawaki Shoji , Sasaki Yasuyuki , Fujii Shingo 
Published: August 2010

AbstractThe case of pregnant woman with Wolff‐Parkinson‐White syndrome, whose paroxysmal supraventricular tachycardia was successfully terminated by intravenous administration of 5–10 mg adenosine triphosphate (ATP), is presented.
A Prospective Study on the Relationship between Intrapartum Maternal Group‐B Streptococcal Concentration and Signs of Infection in Neonates*
Authors: Itakura Atsuo , Kurauchi Osamu , Morikawa Shigehiko , Matsuzawa Katsuji , Mizutani Shigehiko , Tomoda Yutaka 
Published: August 2010

AbstractObjective: Our purpose was to examine the effects of intrapartum vaginal Group‐B streptococcal (GBS) colonization on neonatal signs of infection.Study Design: We performed a quantitative GBS culture of vaginal specimens in 1,280 pregnancies within 24 hours before delivery and examined signs of neonatal infection within 48 hours after birth. Among them, 287 pregnant women had premature ruptures of membranes.Results: The rate of vaginal GBS colonization in groups with and without ruptured membranes was 22.0% and 11.3%, respectively. The incidence of neonates with signs of infection born to GBS‐carrier women in each group was 28.6% and 8.8%, respectively. There were significant differences between the groups with regard to both the rate of colonization and the incidence of infection. Signs of neonatal infection increased in proportion to the maternal GBS concentration only in women with ruptured membranes.Conclusion: This study suggests that there is an important association between maternal GBS concentration and mild neonatal infections after birth, especially in women with premature ruptures of membranes.
Chorionic Villus Sampling: Clinical Experience of the Initial 750 Cases
Authors: Yang Young H. , Park Yong W. , Kim Sei K. , Cho Jae S. , Jeong Mee J. , Kim Haeng S. , Song Chan H. 
Published: August 2010

AbstractObjective: To assess the factors that might influence the success rate, safety and reliability of chorionic villus sampling (CVS) and to evaluate the relationship between CVS and other congenital anomalies.Design: Analysis of the outcome of 750 cases of CVS (730 cases with transcervical and 20 cases with transabdominal).Setting: The outpatient prenatal genetic clinic of a university tertiary care center.Subjects: Seven hundred and fifty pregnant women that underwent CVS for prenatal genetic diagnosis from 7 to 12 weeks of gestation.Results: Advanced maternal age was the most common indication for CVS (32.8%). The overall sampling success rate was 98.0% (735/750), representing 93.9% at 7 to 8 weeks, 98.1% at 9 to 10 weeks, and 98.3% at 11 to 12 weeks of gestation. The majority of cases (93.1%) required one or two aspirations. Cytogenetic analysis routinely included direct overnight and long‐term culture methods which revealed 16 abnormalities (2.2%). Of 735 cases in which CVS was successful, 700 advanced to normal offspring, 17 had therapeutic termination, and 18 resulted in spontaneous abortions; there was an overall fetal loss rate of 2.4% (18/750).Conclusion: CVS in early pregnancy is a relatively safe and reliable method of prenatal genetic diagnosis capable of replacing genetic amniocentesis. However, it must be done by experienced personnel. No congenital anomalies were found to be related to CVS in this series.
Abdomino Perineal Repair of Pulsion Enterocele
Authors: Brieger Geoffrey M. , Korda Andrew R. , Houghton C. Roger S. 
Published: August 2010

AbstractObjectives: To review the techniques, results and complications of the combined abdomino perineal repair and mersilene mesh sacrocolpopexy.Methods: From March 1988 to December 1993; 45 cases of pulsion enterocele were treated by a combination of the Zacharin type abdomino perineal repair and mersilene mesh sacrocolpopexy. Forty cases were followed from between 1 month and 18 months (mean 5.95 months). The notes were reviewed retrospectively.Results: There were 3 recurrences (7.5%). Complications were not insignificant: wound infection in 3, urinary tract infection in 6, bowel dysfunction in 8, ventral hernia, vaginal stricture necessitating surgical release, and brachial nerve plexus injury occurred once. In one patient a peritoneal cyst developed necessitating laparoscopic aspiration.Conclusion: The combined abdomino perineal and sacrocolpopexy procedure offers the restoration of normal anatomy and the relief of the symptoms of prolapse in 92.5% of patients. The complication rate is significant and it should be undertaken as a secondary procedure.
HER‐2/neu Gene Amplification in Cervical Cancer in Chinese Women of Hong Kong and China
Authors: Wong Y. F. , Chung Tony K. H. , Cheung T. H. , Lam S. K. , Tam O. S. , Lu H. J. , Xu F. D. , Chang Allan M. Z. 
Published: August 2010

AbstractObjective: To determine the amplification of proto‐oncogene HER‐2/neu in invasive cervical cancer and its relationship with the stage of disease, grade of tumor and prognosis of patients.Methods: In this retrospective study 70 women with invasive cervical squamous cell carcinoma were included. DNA was extracted from the paraffin‐embedded tumor tissue. The amplification of HER‐2/neu was studied using a differential polymerase reaction (PCR) technique. Assessment of significance was performed using Peason's Chi‐square test and Fisher's exact test.Results: Eleven of the 70 cases (16%) showed an amplification of HER‐2/neu but there was no relation between amplification and tumor histologic grading (p = 0.408) or clinical staging (p = 0.180). Follow‐up information in 67 patients was available. The incidence of amplification in the patients who were alive with disease was not statistically different from that in the patients who were alive with no evidence of disease (p = 0.315). The incidence of amplification in the patients who died of disease was higher than that in the patients who were still alive, but statistical significance did not reached (p = 0.062).Conclusion: The results suggest that HER‐2/neu amplification does exist in a subgroup of invasive cervical cancer and may play a role in cervical carcinogenesis. The role as independent prognostic factor has to be evaluated by further prospective studies.
HLA Sharing, Anti‐Paternal Cytotoxic Antibodies and MLR Blocking Factors in Women with Recurrent Spontaneous Abortion
Authors: Kishore Raj , Agarwal Suraksha , Halder A. , Das V. , Shukla B. R. K. , Agarwal S. S. 
Published: August 2010

AbstractObjective: To study the prevalence of HLA sharing between spouses and its correlation with presence of antipaternal cytotoxic antibody (APCA) and mixed lymphocyte reaction (MLR) blocking factors in recurrent spontaneous aborters (RSA).Design: Study was carried out at Sanjay Gandhi Postgraduate Institute of Medical Sciences (SGPGI), Lucknow, from 1988–1992. Hundred coupes with 3 or more consecutive recurrent spontaneous abortions and equal number of age, parity and ethinically matched normal controls were selected for studying HLA, APCA and MLR blocking factors. Meta‐analysis was performed using standard formula and significance was tested by Chi‐square analysis.Results: Significant HLA sharing was observed in couples with RSA at A and DR loci compared to normal controls (p < 0.001). Twenty‐seven point eight percent of couples with RSA were positive for APCA compared to 49% of controls (p < 0.01). MLR blocking factors were detected in 26% couples with RSA compared to 78% in controls (p < 0.001). An inverse correlation between HLA sharing and APCA and MLR positivity was demonstrated.Conclusion: The study supports that greater HLA sharing between spouses, associated with lack of an appropriate immune response to them could be responsible for RSA.
Analysis of 23 Cases of Primary Carcinoma of the Fallopian Tube over 50 Years
Authors: Huber‐Buchholz Marie‐Madeleine , Buchholz Niels‐Peter , Staehelin Jody 
Published: August 2010

AbstractThe authors report on 23 cases of primary Fallopian tube carcinoma occurring over the past 50 years. In addition, the literature of the past 30 years was reviewed. The 5‐year survival rate was 40%, increasing considerably with lower tumor stage or better tumor differentiation. The adjuvant therapies used did not prolong survival. Results were compared to other studies, and diagnostic and therapeutic trends are pointed out. Due to the rareness of the tumor, there are no controlled studies as to the effectiveness of therapeutic regimens. Therapy is purely empiric and usually follows the guidelines for ovarian cancer. There are no established tools for a safe preoperative diagnosis. The tumor is highly aggressive and quickly spreading. Initial tumor stage and differentiation are determinants for the prognosis. Therefore, a radical approach is indicated whenever a tubular malignancy cannot be excluded.
Use of Recombinant Tissue‐Type Plasminogen Activator to Treat Massive Pulmonary Embolism after Cesarean Section: A Case Report
Authors: Onoyama Yoshimichi , Minamitani Makoto , Takeuchi Hajime , Sakai Sunao , Eguchi Hiroyuki 
Published: August 2010

AbstractA 30‐year‐old primigravida, delivering by cesarean section, went into shock with cardiac arrest due to pulmonary thromboembolism. Thrombolytic therapy with recombinant‐tissue‐type plasminogen activator (rt‐PA) induced a rapid improvement in both the hemodynamic and respiratory conditions. This case shows the marked efficacy of rt‐PA in treating massive pulmonary thromboembolism. Close attension must be given to the patient in such a case, however, because the risk of hemorrhagic complication exists.