bluuebunny/crossref_metadata_2025_split huggingface dataset:
Shortest Paths in Road Networks: From Practice to Theory and Back
Authors: Delling Daniel , Goldberg Andrew V. , Werneck Renato F. 
Published: December 2011

Abstract
We illustrate the use of the scientific method in algorithmics by surveying recent developments in route planning on road networks. Several speed-up techniques proposed in the past decade are intuitive, elegant, and very efficient in practice, but lacked a theoretical explanation of their observed performance. By introducing a formal definition of road networks, recent theoretical work closed this gap. It also predicted that a previously untested algorithm should be even faster, which was confirmed by a subsequent implementation.
A Bayesian Antedependence Model for Whole Genome Prediction
Authors: Yang Wenzhao , Tempelman Robert J 
Published: December 2011

AbstractHierarchical mixed effects models have been demonstrated to be powerful for predicting genomic merit of livestock and plants, on the basis of high-density single-nucleotide polymorphism (SNP) marker panels, and their use is being increasingly advocated for genomic predictions in human health. Two particularly popular approaches, labeled BayesA and BayesB, are based on specifying all SNP-associated effects to be independent of each other. BayesB extends BayesA by allowing a large proportion of SNP markers to be associated with null effects. We further extend these two models to specify SNP effects as being spatially correlated due to the chromosomally proximal effects of causal variants. These two models, that we respectively dub as ante-BayesA and ante-BayesB, are based on a first-order nonstationary antedependence specification between SNP effects. In a simulation study involving 20 replicate data sets, each analyzed at six different SNP marker densities with average LD levels ranging from r2 = 0.15 to 0.31, the antedependence methods had significantly (P &lt; 0.01) higher accuracies than their corresponding classical counterparts at higher LD levels (r2 &gt; 0. 24) with differences exceeding 3%. A cross-validation study was also conducted on the heterogeneous stock mice data resource (http://mus.well.ox.ac.uk/mouse/HS/) using 6-week body weights as the phenotype. The antedependence methods increased cross-validation prediction accuracies by up to 3.6% compared to their classical counterparts (P &lt; 0.001). Finally, we applied our method to other benchmark data sets and demonstrated that the antedependence methods were more accurate than their classical counterparts for genomic predictions, even for individuals several generations beyond the training data.
The Genetic Basis of Heterosis: Multiparental Quantitative Trait Loci Mapping Reveals Contrasted Levels of Apparent Overdominance Among Traits of Agronomical Interest in Maize (Zea mays L.)
Authors: Larièpe A , Mangin B , Jasson S , Combes V , Dumas F , Jamin P , Lariagon C , Jolivot D , Madur D , Fiévet J , Gallais A , Dubreuil P , Charcosset A , Moreau L 
Published: December 2011

Abstract
Understanding the genetic bases underlying heterosis is a major issue in maize (Zea mays L.). We extended the North Carolina design III (NCIII) by using three populations of recombinant inbred lines derived from three parental lines belonging to different heterotic pools, crossed with each parental line to obtain nine families of hybrids. A total of 1253 hybrids were evaluated for grain moisture, silking date, plant height, and grain yield. Quantitative trait loci (QTL) mapping was carried out on the six families obtained from crosses to parental lines following the “classical” NCIII method and with a multiparental connected model on the global design, adding the three families obtained from crosses to the nonparental line. Results of the QTL detection highlighted that most of the QTL detected for grain yield displayed apparent overdominance effects and limited differences between heterozygous genotypes, whereas for grain moisture predominance of additive effects was observed. For plant height and silking date results were intermediate. Except for grain yield, most of the QTL identified showed significant additive-by-additive epistatic interactions. High correlation observed between heterosis and the heterozygosity of hybrids at markers confirms the complex genetic basis and the role of dominance in heterosis. An important proportion of QTL detected were located close to the centromeres. We hypothesized that the lower recombination in these regions favors the detection of (i) linked QTL in repulsion phase, leading to apparent overdominance for heterotic traits and (ii) linked QTL in coupling phase, reinforcing apparent additive effects of linked QTL for the other traits.
Novel Transcript Truncating Function of Rap1p Revealed by Synthetic Codon-Optimized Ty1 Retrotransposon
Authors: Yarrington Robert M , Richardson Sarah M , Lisa Huang Cheng Ran , Boeke Jef D 
Published: December 2011

Abstract
Extensive mutagenesis via massive recoding of retrotransposon Ty1 produced a synthetic codon-optimized retrotransposon (CO-Ty1). CO-Ty1 is defective for retrotransposition, suggesting a sequence capable of down-regulating retrotransposition. We mapped this sequence to a critical ∼20-bp region within CO-Ty1 reverse transcriptase (RT) and confirmed that it reduced Ty1 transposition, protein, and RNA levels. Repression was not Ty1 specific; when introduced immediately downstream of the green fluorescent protein (GFP) stop codon, GFP expression was similarly reduced. Rap1p mediated this down-regulation, as shown by mutagenesis and chromatin immunoprecipitation. A regular threefold drop is observed in different contexts, suggesting utility for synthetic circuits. A large reduction of RNAP II occupancy on the CO-Ty1 construct was observed 3′ to the identified Rap1p site and a novel 3′ truncated RNA species was observed. We propose a novel mechanism of transcriptional regulation by Rap1p whereby it serves as a transcriptional roadblock when bound to transcription unit sequences.
Pediatric Sports-Related Concussion Produces Cerebral Blood Flow Alterations
Authors: Maugans Todd A. , Farley Chad , Altaye Mekibib , Leach James , Cecil Kim M. 
Published: December 2011

Objectives:The pathophysiology of sports-related concussion (SRC) is incompletely understood. Human adult and experimental animal investigations have revealed structural axonal injuries, decreases in the neuronal metabolite N-acetyl aspartate, and reduced cerebral blood flow (CBF) after SRC and minor traumatic brain injury. The authors of this investigation explore these possibilities after pediatric SRC.Patients And Methods:Twelve children, ages 11 to 15 years, who experienced SRC were evaluated by ImPACT neurocognitive testing, T1 and susceptibility weighted MRI, diffusion tensor imaging, proton magnetic resonance spectroscopy, and phase contrast angiography at &lt;72 hours, 14 days, and 30 days or greater after concussion. A similar number of age- and gender-matched controls were evaluated at a single time point.Results:ImPACT results confirmed statistically significant differences in initial total symptom score and reaction time between the SRC and control groups, resolving by 14 days for total symptom score and 30 days for reaction time. No evidence of structural injury was found on qualitative review of MRI. No decreases in neuronal metabolite N-acetyl aspartate or elevation of lactic acid were detected by proton magnetic resonance spectroscopy. Statistically significant alterations in CBF were documented in the SRC group, with reduction in CBF predominating (38 vs 48 mL/100 g per minute; P = .027). Improvement toward control values occurred in only 27% of the participants at 14 days and 64% at &gt;30 days after SRC.Conclusions:Pediatric SRC is primarily a physiologic injury, affecting CBF significantly without evidence of measurable structural, metabolic neuronal or axonal injury. Further study of CBF mechanisms is needed to explain patterns of recovery.
Trends in Mental Health and Substance Abuse Services at the Nation’s Community Health Centers: 1998–2003
Authors: Druss Benjamin G. , Bornemann Thomas , Fry-Johnson Yvonne W. , McCombs Harriet G. , Politzer Robert M. , Rust George 
Published: December 2011

Objective. We examined trends in delivery of mental health and substance abuse services at the nation’s community health centers. Methods. Analyses used data from the Health Resources and Services Administration (HRSA), Bureau of Primary Care’s (BPHC) 1998 and 2003 Uniform Data System, merged with county-level data. Results. Between 1998 and 2003, the number of patients diagnosed with a mental health/substance abuse disorder in community health centers increased from 210 000 to 800 000. There was an increase in the number of patients per specialty mental health/substance abuse treatment provider and a decline in the mean number of patient visits, from 7.3 visits per patient to 3.5 by 2003. Although most community health centers had some on-site mental health/substance abuse services, centers without on-site services were more likely to be located in counties with fewer mental health/substance abuse clinicians, psychiatric emergency rooms, and inpatient hospitals. Conclusions. Community health centers are playing an increasingly central role in providing mental health/substance abuse treatment services in the United States. It is critical both to ensure that these centers have adequate resources for providing mental health/substance abuse care and that they develop effective linkages with mental health/substance abuse clinicians in the communities they serve.
Health Care Reform and Social Movements in the United States
Authors: Hoffman Beatrix 
Published: December 2011

Because of the importance of grassroots social movements, or “change from below,” in the history of US reform, the relationship between social movements and demands for universal health care is a critical one. National health reform campaigns in the 20th century were initiated and run by elites more concerned with defending against attacks from interest groups than with popular mobilization, and grassroots reformers in the labor, civil rights, feminist, and AIDS activist movements have concentrated more on immediate and incremental changes than on transforming the health care system itself. However, grassroots health care demands have also contained the seeds of a wider critique of the American health care system, leading some movements to adopt calls for universal coverage.
Social Factors and Periodontitis in an Older Population
Authors: Borrell Luisa N. , Burt Brian A. , Neighbors Harold W. , Taylor George W. 
Published: December 2011

Objectives. We assessed the prevalences of periodontitis by education and income levels among US adults with data from the third National Health and Nutrition Examination Survey. Methods. The study was limited to non-Hispanic Blacks, Mexican Americans, and non-Hispanic Whites 50 years of age or older with a complete periodontal assessment during the dental examination. Results. Blacks with higher education and income levels had a significantly higher prevalence of periodontitis than their White and Mexican-American counterparts. The relationship between income level and periodontitis was modified by race/ethnicity. High-income Blacks exhibited a higher prevalence of periodontitis than did low-income Blacks and high-income Whites. Conclusions. Our findings call attention to the importance of recognizing socioeconomic status–related health differences across racial/ethnic groups within the social, political, and historical context.
Learning New Technologies: The Effect of Ease of Learning
Authors: Loraas Tina M. , Diaz Michelle Chandler 
Published: December 2011

ABSTRACT
Service professionals are often confronted with situations where they have the choice about whether to learn a new technology that could create efficiencies on both current and future engagements. We investigate how the perception of ease of learning affects this decision to voluntarily learn a new technology in the post-adoptive context. Using the elaboration likelihood model as a framework, we predict and find evidence that ease of learning perceptions drive the level of processing undergone by the potential user. When technology is easy to use, potential users rely on their situational learning dispositions. However, when the technology is difficult, suggesting a greater risk of failure, situational goal orientations are less influential, and potential users rely more on dispositional goal orientations. Our findings have implications for future research on technology acceptance and use, as well as ramifications for encouraging technology use “on the job.”
Data Availability: Full instrument provided in Appendix A.
A Meta-Analysis of the Effects of IT Investment on Firm Financial Performance
Authors: Lim Jee-Hae , Dehning Bruce , Richardson Vernon J. , Smith Rodney E. 
Published: December 2011

ABSTRACT
We use meta-analysis techniques to examine research choices that affect findings with respect to the return on IT investment. Recent research has established that IT investment is substantially related to firm financial performance. We find, however, that the relationship between IT investment and performance varies, depending on how both financial performance and IT investment are measured. Despite criticism of accounting measures as indicators of IT payoff, we find that the relationship is often stronger in studies that employ accounting measures rather than market measures of firm performance. This difference is driven by research that focuses on the process-level impacts of IT investment. Furthermore, the relationship is also stronger when IT investment is measured as IT strategy or spending, rather than IT capability. We discuss the practical implications of the results of our meta-analysis and suggest new directions for future theory development and research.
Data Mining of Electronic Mail and Auditing: A Research Agenda
Authors: Debreceny Roger S. , Gray Glen L. 
Published: December 2011

ABSTRACTA potentially important form of audit evidence is corporate email, which includes the background, intent, and outcome of managerial actions. Emails are semi-structured data, with known fields for sender, recipient, subject, and date, as well as the email body and attachments. Data mining of emails (DME) combines understanding of social networks, textual analysis using natural language processing and other techniques, and domain knowledge. Email data mining research received a considerable boost by the availability of a large archive of emails from the now-defunct Enron Corporation. The paper provides an overview of DME techniques, and the potential expanded applications of DME by auditors. The paper also discusses a set of research areas and research opportunities.
Outbreaks of severe enteric disease associated with Eimeria furonis infection in ferrets (Mustela putorius furo) of 3 densely populated groups
Authors: Sledge Dodd G. , Bolin Steven R. , Lim Ailam , Kaloustian Lisa L. , Heller Ruth L. , Carmona Franklin M. , Kiupel Matti 
Published: December 2011

Abstract
Case Description—3 unrelated, densely populated, dynamic ferret populations with severe outbreaks of enteric coccidiosis were evaluated.
Clinical Findings—In each outbreak, morbidity rate was high, there were an appreciable number of deaths, and ferrets of all ages were affected. Affected individuals had acute onset of diarrhea, and feces often contained frank or digested blood. Other clinical signs included dehydration, weakness, lethargy, and weight loss. Fecal examinations of affected ferrets revealed sporadic and inconsistent shedding of coccidial oocysts. Necropsy findings included moderate to marked atrophic enteritis associated with numerous intraepithelial and fewer extracellular coccidial life stages. Sporulated oocysts isolated from feces were consistent with Eimeria furonis. A PCR assay was performed on formalin-fixed, paraffin-embedded sections of intestine for the gene encoding the small subunit of rRNA yielded products with sequences identical to those described for E furonis.
Treatment and Outcome—Supportive care and treatment with sulfadimethoxine over the course of these outbreaks was palliative, but long-term treatment was required and failed to completely eradicate infection as identified by the subsequent finding of oocysts in fecal samples.
Clinical Relevance—Enteric coccidiosis due to infection with E furonis has typically been reported to be subclinical rather than to cause severe gastrointestinal disease in ferrets. This report indicated that infection with E furonis may have contributed to severe enteric disease with high morbidity and mortality rates in 3 densely populated, dynamic groups of ferrets. Furthermore, long-term treatment with anti-coccidials may be required in outbreak situations, but may be ineffectual in completely eradicating infection.
Are There Important Differences in Success and in Organizational Culture between Family Companies in Production and Service Sector in Slovenia?
Authors: Zajec Maja , Roblek Matjaž 
Published: December 2011

Are There Important Differences in Success and in Organizational Culture between Family Companies in Production and Service Sector in Slovenia?
In this article we will introduce the development of those organizational culture elements, which influence importantly on company successfulness in family companies. The research was performed in 24 Slovenian companies with 524 responded survey questionnaires from field of services, consultancy and computer equipment, trade counter, production, road freight traffic and civil engineering.
With this analysis we found out the answer to the question in family loyalty to the company, management style, loyalty and mutual trust system, strategic emphasis, criteria for successful business operations, stimulation (rewarding), process of continuous improvement, business ethics of the company, organization, values of the employees, and satisfaction of the employees in those companies. The collected data are important from the aspect of the organizational culture influence on the future growth or eventually their stagnation.
Progression of cerebrospinal fluid cell count and differential over a treatment course of shunt infection
Authors: Fulkerson Daniel H. , Sivaganesan Ahilan , Hill Jason D. , Edwards John R. , Shoja Mohammadali M. , Boaz Joel C. , Jea Andrew 
Published: December 2011

Object
The physiological reaction of CSF white blood cells (WBCs) over the course of treating a shunt infection is undefined. The authors speculated that the CSF WBC count varies with different infecting organisms in peak level and differential percentage of polymorphonuclear (PMN) leukocytes, lymphocytes, monocytes, and eosinophils. The authors hope to identify clinically useful trends in the progression of CSF WBCs by analyzing a large group of patients with successfully treated shunt infections.

Methods
The authors reviewed 105 successfully treated cases of shunt infections at Riley Hospital for Children. The study dates ranged from 2000 to 2004; this represented a period prior to the routine use of antibiotic-impregnated shunt catheters. They analyzed the following organisms: coagulase-negative staphylococci, Staphylococcus aureus, Propionibacterium acnes, Streptococcal species, and gram-negative organisms. The initial CSF sample at diagnosis was analyzed, as were levels over 14 days of treatment. Model fitting was performed to generate curves for the expected progression of the WBC counts and the differential PMN leukocytes, lymphocyte, monocyte, and eosinophil percentages.

Results
Gram-negative organisms resulted in a higher initial (p = 0.03) and peak WBC count with a greater differential of PMN leukocytes compared with other organisms. Propionibacterium acnes infections were associated with a significantly lower WBC count and PMN leukocytes percentage (p = 0.02) and higher eosinophil percentage (p = 0.002) than other organisms. The pattern progression of the CSF WBC count and differential percentages was consistent for all infections. There was an initial predominance of PMN leukocytes, followed by a delayed peak of lymphocytes, monocytes, and eosinophils over a 14-day course. All values trended toward zero over the treatment course.

Conclusions
The initial and peak levels of CSF WBCs vary with the infecting organisms. The CSF cell counts showed a predictable pattern during the treatment of shunt infection. These trends may be useful to the physician in clinical decision making, although there is a wide range of variability.
Supracerebellar infratentorial endoscopically controlled resection of pineal lesions: case series and operative technique
Authors: Uschold Timothy , Abla Adib A. , Fusco David , Bristol Ruth E. , Nakaji Peter 
Published: December 2011

Object
The heterogeneous clinical manifestations and operative characteristics of pathological entities in the pineal region represent a significant challenge in terms of patient selection and surgical approach. Traditional surgical options have included endoscopic transventricular resection; open supratentorial microsurgical approaches through the midline, choroidal fissure, lateral ventricle, and tentorium; and supracerebellar infratentorial (SCIT) approaches through the posterior fossa. The object of the current study was to review the preoperative characteristics and outcomes for a cohort of patients treated purely via the novel endoscopically controlled SCIT approach.

Methods
A single-institution series of 9 consecutive patients (4 male and 5 female patients [10 total cases]; mean age 21 years, range 6–37 years) treated via the endoscopically controlled SCIT approach for a pathological entity in the pineal region was retrospectively reviewed. The mean follow-up time was 13.2 months.

Results
The endoscopically controlled SCIT approach was successfully used to approach a variety of pineal lesions, including pineal cysts (6 patients), epidermoid tumor, WHO Grade II astrocytoma (initial biopsy and recurrence), and malignant mixed germ cell tumor (1 patient each). Gross-total resection and/or adequate cyst fenestration was achieved in 8 cases. Biopsy with conservative debulking was performed for the single case of low-grade astrocytoma and again at the time of recurrence.
The mean preoperative tumor and cyst volumes were 9.9 ± 4.4 and 3.7 ± 3.2 cm3, respectively. The mean operating times were 212 ± 71 minutes for tumor cases and 177 ± 72 minutes for cysts. Estimated blood loss was less than 150 ml for all cases. A single case (pineal cyst) was converted to an open microsurgical approach to enhance visualization. There were no operative complications, as well as no documented CSF leaks, additional CSF diversion procedures, or air emboli. Seven patients underwent concomitant third ventriculostomy into the quadrigeminal cistern. At the time of the last follow-up evaluation, all patients had a stable or improved modified Rankin Scale score.

Conclusions
The endoscopically controlled SCIT approach may be used for the biopsy and resection of appropriately selected solid tumors of the pineal region, in addition to the fenestration and/or resection of pineal cysts. Preoperative considerations include patient presentation, anticipated disease and vascularity, degree of local venous anatomical distortion, and selection of optimal paramedian trajectory.