bluuebunny/crossref_metadata_2025_split huggingface dataset:
A first-in-human (FIH), phase 1/2, dose-escalation, dose-optimization, and dose-expansion study of PARP1-selective inhibitor IMP1734 in participants with advanced solid tumors.
Authors: Sonpavde Guru P. , Call Justin A , Falchook Gerald Steven , Garmezy Benjamin , Rasco Drew W. , Liu Lan , Niu Tiantian , He Jenna , Zhang Congcong , Kochan Jarema , Rebello Sam , Russo Giuseppe , Chen Viola , Krishnan Suba 
Published: June 2024

TPS3191 Background: PARP inhibitors (PARPi) selectively kill tumor cells harboring genetic mutations in critical DNA repair genes (e.g., BRCA1/2). While several approved nonselective PARPi have provided robust anti-tumor activity, they are associated with significant hematologic toxicities that limit dose intensity and clinical benefit. Drugs that selectively inhibit PARP1 but spare PARP2 may improve the risk-benefit profile for this class of therapies by retaining anti-tumor activity while avoiding PARP2-related toxicities. IMP1734 (EIK1003) is a potent PARP1-selective inhibitor that inhibits tumor growth in nonclinical models and may widen the therapeutic index in tumors where non-selective PARPi have demonstrated efficacy. Methods: Study EIK1003-001 (IMP1734-101) is a global, multi-center, Phase 1/2 study evaluating the safety and potential antitumor activity of IMP1734 in participants with advanced solid tumors. The study has 3 parts: Part 1 (FIH; Dose Escalation), Part 2 (Dose Optimization), and Part 3 (Dose Expansion at the recommended dose for expansion [RDE]). Part 1 of this study is currently enrolling and consists of dose escalation of IMP1734 in study participants with advanced/recurrent/metastatic ovarian, breast, or prostate cancer with suspected deleterious/deleterious mutations in a pre-specified panel of homologous recombination repair (HRR) genes (n = 70). Eligible participants must be ≥ 18 years of age, have histologically or cytologically confirmed tumors as indicated in each study part, and at least 1 RECIST v1.1-measurable lesion and/or pre-specified serum tumor-specific marker. All participants must have a deleterious or suspected deleterious mutation in select HRR genes. Primary endpoints include safety and tolerability (evaluation of dose-limiting toxicities and determining the maximum tolerated dose, maximum achievable dose, and RDE). Secondary endpoints include evaluation of the pharmacokinetic parameters of IMP1734 and measures of efficacy, including overall response rate, duration of response, progression-free survival, and overall survival. Exploratory endpoints include analysis of pharmacodynamic biomarkers, serial ctDNA measurements, and patient quality-of-life measures. This study opened on 11 Dec 2023. Clinical trial information: NCT06253130 .
Correlation between the structural phase transition and magnetic properties of sol-gel synthesized
nanoparticles
Authors: Jharwal Swati , Verma Vivek Kumar , Kumar Arvind 
Published: June 2024

Abstract
The La2CoFeO6 (LCFO) nanoparticles were synthesized using the sol-gel method and calcined at 600

, 800

, and 1000

. The X-ray diffraction data confirm the successful formation of LCFO nanoparticles. The crystallite size was observed to increase from ∼13 nm to ∼26 nm as the calcination temperature rose. Detailed Rietveld analysis revealed the coexistence of both orthorhombic (Pnma: S.G. 62) and rhombohedral (

: S.G. 167) phases in the LCFO samples. A two-phase Rietveld refinement demonstrated a structural phase transition (from Pnma to

) as the calcination temperature increased. FESEM micrographs exhibited a granular morphology for the LCFO nanoparticles, and the grain size was observed to increase with the elevated calcination temperature. Magnetization curves illustrated an increase in magnetization with a decrease in crystallite size or a reduction in calcination temperature for LCFO nanoparticles. At higher calcination temperatures, the rhombohedral phase displayed significant antisite disorder, resulting in the disruption of long-range ferromagnetic ordering in the material and a subsequent decrease in maximum magnetization.
Brown Gathering
Authors: Leon Adrian de 
Published: June 2024

Abstract
Through a sustained engagement with The Precarious Life of the Parol, an installation art exhibition by the Filipinx artist Diane Williams, this essay theorizes “brown gathering”: a quotidian practice of archiving that mobilizes the kinship networks of minoritarian subjects as an affective and circulatory infrastructure of collecting, preserving, and (re)signifying the objects of brown life. Brown gathering simultaneously attests to the intimacies of state violence and the practices of minoritarian subjects. In Parol, named after a Filipinx Christmas ornament of Spanish and native origin, Williams turns toward this curatorial practice of making art with trash objects as a way to reckon with the archival absences of Philippine history. This investigation of Williams’s pieces, all made from trash objects that her family donated to her, concerns three categories: skeletal frames (wood and wire), used to explore archives of excess and mess; plastics, used to speak about the temporality of diaspora; and discarded food containers (SPAM cans and sauce mixes), used to theorize the politics of the brown body. These objects, like the brown subjects that signify them, are testaments to the ongoing plunder of empire and to what empire jettisons around the world.
PLETHORA transcription factors promote early embryo development through induction of meristematic potential
Authors: Kerstens Merijn , Galinha Carla , Hofhuis Hugo , Nodine Michael , Pardal Renan , Scheres Ben , Willemsen Viola 
Published: June 2024

ABSTRACT
Plants are dependent on divisions of stem cells to establish cell lineages required for growth. During embryogenesis, early division products are considered to be stem cells, whereas during post-embryonic development, stem cells are present in meristems at the root and shoot apex. PLETHORA/AINTEGUMENTA-LIKE (PLT/AIL) transcription factors are regulators of post-embryonic meristem function and are required to maintain stem cell pools. Despite the parallels between embryonic and post-embryonic stem cells, the role of PLTs during early embryogenesis has not been thoroughly investigated. Here, we demonstrate that the PLT regulome in the zygote, and apical and basal cells is in strong congruence with that of post-embryonic meristematic cells. We reveal that out of all six PLTs, only PLT2 and PLT4/BABY BOOM (BBM) are expressed in the zygote, and that these two factors are essential for progression of embryogenesis beyond the zygote stage and first divisions. Finally, we show that other PLTs can rescue plt2 bbm defects when expressed from the PLT2 and BBM promoters, establishing upstream regulation as a key factor in early embryogenesis. Our data indicate that generic PLT factors facilitate early embryo development in Arabidopsis by induction of meristematic potential.
The retromer and retriever systems are conserved and differentially expanded in parabasalids
Authors: Shinde Abhishek Prakash , Kučerová Jitka , Dacks Joel Bryan , Tachezy Jan 
Published: June 2024

ABSTRACT
Early endosomes sort transmembrane cargo either for lysosomal degradation or retrieval to the plasma membrane or the Golgi complex. Endosomal retrieval in eukaryotes is governed by the anciently homologous retromer or retriever complexes. Each comprises a core tri-protein subcomplex, membrane-deformation proteins and interacting partner complexes, together retrieving a variety of known cargo proteins. Trichomonas vaginalis, a sexually transmitted human parasite, uses the endomembrane system for pathogenesis. It has massively and selectively expanded its endomembrane protein complement, the evolutionary path of which has been largely unexplored. Our molecular evolutionary study of retromer, retriever and associated machinery in parabasalids and its free-living sister lineage of Anaeramoeba demonstrates specific expansion of the retromer machinery, contrasting with the retriever components. We also observed partial loss of the Commander complex and sorting nexins in Parabasalia but complete retention in Anaeramoeba. Notably, we identified putative parabasalid sorting nexin analogs. Finally, we report the first retriever protein localization in a non-metazoan group along with retromer protein localization in T. vaginalis.
THE FRACTURE ANKLE IMPLANT REVIEW (FAIR) STUDY: A NATIONAL MULTICENTRE RETROSPECTIVE REVIEW OF IMPLANTS, FIXATION METHODS, AND OUTCOMES IN FIBULA FIXATION IN ANKLE FRACTURES
Authors: Fishley W. , Morrison R. , Baldock T. , Hilley A. , Baker P. , Townshend D. 
Published: June 2024

BackgroundIn fixation of the fibula in ankle fractures, AO advocate using a lag screw and one-third tubular neutralisation plate for simple patterns. Where a lag screw cannot be placed, bridging fixation is required. A local pilot service evaluation previously identified variance in use of locking plates in all patterns with significant cost implications. The FAIR study aimed to evaluate current practice and implant use across the United Kingdom (UK) and review outcomes and complication rates between different fibula fixation methods.MethodThe study was supported by CORNET, the North East trainee research collaborative, and BOTA. Data was collected using REDCap from 22 centres in the UK retrospectively for a one-year period between 1st January 2019 and 31st December 2019 on injury mechanism, fracture characteristics, comorbidities, fixation and complications. Follow-up data was collected to at least two-years from the time surgery.Results1448 ankle fractures which involved fixation of the fibula were recorded; one-third tubular plate was used in 866 (59.8%) cases, a locking plate in 463 (32.0%) cases and other methods in 119 (8.2%) cases. There was significant difference between centres (p<0.001) in implant type used. Other factors associated with implant type were age, diabetes, osteoporosis, open fractures, fracture pattern and the presence of comminution. Incidence of lateral wound breakdown was higher in locking plates than one-third tubular plates (p<0.05). There was no significant difference in infection, non-union, fixation failure or removal of metalware.ConclusionThere is significant variation in practice in the UK in implant use for fixation of the fibula in ankle fractures. Potentially unnecessary use of locking plates, where a one-third tubular shows equivalent outcomes, incurs additional cost and may increase the risk of lateral wound breakdown. We would encourage surgeons with high locking plate usage to evaluate their own unit's practice against this data.
DELTOID LIGAMENT RECONSTRUCTION IN ANKLE FRACTURES: DOES IT PREVENT PES PLANUS?
Authors: Aamir J. , Huxley T. , Clarke M. , Dalal N. , Johnston A. , Rigkos D. , Kutty J. , Gunn C. , Condurache C. , McKeever D. , Gomaa A. , Mason L. 
Published: June 2024

IntroductionDeltoid ligament reconstruction (DLR) is an important factor in the consideration of pes planus deformity. There is little evidence in the literature determining whether DLR could mitigate the risk of patients acquiring flat foot postoperatively following deltoid ligament injury.AimOur objective was to establish if there was a difference in pes planus deformity in patients who underwent DLR during their ankle fracture fixation compared to those who did not.MethodsA retrospective analysis of post-operative weight bearing radiographs was performed of patients who underwent ankle fracture fixation. Inclusion criteria were confirmed deltoid instability presurgery without medial malleolar fracture and post operative weightbearing radiographs at least 6 weeks post-fixation. Patients were categorised into no deltoid ligament reconstruction (nDLR) and having DLR. Radiographic pes planus parameters involved Meary's Angle assessment. Other fracture morphology was classified.ResultsA total 723 ankle fractures were screened. 122 patients were included for further analysis. There were 94 patients in the nDLR group and 28 patients in DLR group. The mean Meary's Angle was 15.81 (95% CI 14.06, 17.56) degrees in the nDLR group and −.2 (95% CI −3.86, 3.82) in the DLR group. This was statistically significant (p<.001). There was no significant difference in medial clear space measurements (2.90mm v 3.19mm, p = 0.145). There were significantly more pes planus patients in the nDLR than the DLR group (p<.001, 90.5% vs 25%).ConclusionIn this study there was significantly greater pes planus parameters in patients not undergoing DLR. Patients undergoing DLR had on average normal parameters, whilst those not undergoing DLR had on average severe pes planus. The benefits of DLR are not only maintaining ankle stability but maintaining medial arch integrity, and this should be taken into account in a future study on DLR.
A MORPHOLOGICAL REVIEW OF MEDIAL MALLEOLAR FRACTURES: ARE THERE ANY FACTORS WHICH MAY PREDISPOSE TO NONUNION AND MALUNION?
Authors: Aamir J. , Caldwell R. , Long S. , Sreenivasan S. , Mayrotas J. , Panera A. , Jeevaresan S. , Mason L. 
Published: June 2024

BackgroundMany approaches to management of medial malleolar fractures are described in the literature however, their morphology is under investigated. The aim of this study was to analyse the morphology of medial malleolar fractures to identify any association with medial malleolar fracture non-union or malunion.MethodsPatients who had undergone surgical fixation of their MMF were identified from 2012 to 2022, using electronic patient records in a single centre. Analysis of their preoperative, intraoperative, and postoperative radiographs was performed to determine their morphology and prevalence of non-union and malunion. Lauge-Hansen classification was used to characterise ankle fracture morphology and Herscovici classification to characterise MMF morphology.ResultsA total of 650 patients were identified across a 10-year period which could be included in the study. The overall non-union rate for our cohort was 18.77% (122/650). The overall malunion rate was 6.92% (45/650). There was no significant difference in union rates across the Herscovici classification groups. Herscovici type A fractures were significantly more frequently malreduced at time of surgery as compared to other fracture types (p=.003). Medial wall blowout combined with Hercovici type B fractures showed a significant increase in malunion rate. There is a higher rate of bone union in patients who have been anatomically reduced.ConclusionThe morphology of medial malleolar fractures does have an impact of the radiological outcome following surgical management. Medial wall blowout fractures were most prevalent in adduction-type injuries; however, it should not be ruled out in rotational injuries with medial wall blowouts combined with and Herscovici type B fractures showing a significant increase in malunions. Herscovici type A fractures had significantly higher malreductions however the clinical implications of mal reducing small avulsions is unknown.
FILOSOFIA NOS MOLDES DA POESIA
Authors: BATLIČKOVÁ EVA 
Published: June 2024

RESUMO: O presente artigo procura contextualizar a crítica de Flusser ao discurso acadêmico na filosofia e a busca das alternativas que recorrem a elementos literários. Fontes de inspiração de Flusser podem ser encontradas na filosofia alemã das décadas de 1930 e 1940, mas também no próprio ambiente cultural e intelectual de Praga. Embora Flusser tenha se tornado conhecido pela forma ensaística de seus textos, focamos aos seus primeiros passos no campo da escrita que se deram no campo literário no sentido estrito do termo. Levantamos uma série de aspectos na sua peça poética de teatro Saul (1936) com intuito de apontar às raízes do seu trabalho com texto e do modo de abordar tanto os problemas urgentes da sua época como os temas essencialmente filosóficos.
PALAVRAS-CHAVE: Filosofia alemã, Poesia, Drama, Antissemitismo, Segunda Guerra Mundial.

ABSTRACT: This article seeks to contextualize Flusser's criticism of academic discourse in philosophy and the search for alternatives that use literary elements. Sources of Flusser's inspiration can be found in German philosophy of the 1930s and 1940s, but also in Prague's own cultural and intellectual environment. Although Flusser became known for the essayistic form of his texts, we focus on his first steps in the field of writing, which took place in the literary field in the strict sense of the term. We raised a series of aspects in his poetic play Saul (1936) with the aim of pointing out the roots of his work with text and the way he approached both the urgent problems of his time and essentially philosophical themes.
KEYWORDS: German philosophy, Poetry, Drama, Anti-Semitism, World War II.
3D imaging with large range dynamics and simultaneous accurate speed measurement
Authors: Feneyrou Patrick , Martin Aude , Dolfi Daniel , Payot Etienne 
Published: June 2024

In this paper, we describe 3D imaging experiments performed using a frequency modulated continuous wave (FMCW) LIDAR. A detailed study of noise and signal statistics is provided in order to analyze the sensitivity of our FMCW LIDAR, and its capability to image complex scenes over a broad range (up to 3 km) is demonstrated. An image example is also given to illustrate that simultaneous measurement of the speed for each pixel gives additional information that can be used to help segmentation algorithms and target classification. Although 3D imaging using the FMCW system has already been demonstrated, the demonstrated range is generally limited to a few 100 m. In this paper, 3D imaging up to 3 km is achieved while preserving compactness and ruggedness to the various environmental conditions.
Hyperspectral dark-field optical microscopy correlated to atomic force microscopy for the analysis of single plasmonic nanoparticles: tutorial
Authors: Abadie Claire , Liu Mingyang , Prado Yoann , Pluchery Olivier 
Published: June 2024

Plasmonic nanostructures are actively investigated for their optical properties and for a wide range of applications in nanophotonics, biosensing, photocatalysis, hot carrier physics, and advanced cancer therapies. The localized surface plasmon resonance (LSPR) can be excited in gold or silver nanoparticles or in more complex nanostructures and gives rise to a wide range of unique optical properties. It is often critical to be able to localize individual plasmonic nanoparticles and simultaneously measure their spectrum. This is known as hyperspectral microscopy. In this tutorial, we describe and carefully explain how to achieve this goal with an optical microscope equipped with a dark-field objective and an optical spectrometer. The images and the scattering spectra of spherical gold nanoparticles with diameters of 90, 70, 50, and 25 nm are recorded. We compare them with the scattering spectra predicted with the Mie formula (LSPR peaks measured at 553, 541, 535, and 534 nm, respectively). The optical images are limited by the diffraction, and this is discussed in the framework of the Abbe equation. We also describe a strategy to easily correlate the optical images with atomic force microscope images of the samples. This allows us to precisely relate the morphology of the nanoparticles with their optical images, their color, and their optical spectrum. The case of non-spherical nanostructures, namely, dimers of nanoparticles, is also discussed. This approach allows a relatively low-cost setup and efficient characterization method that will be helpful for teachers who want to introduce their students to the wide topics of plasmonics. This will also be useful for labs seeking an affordable method to investigate the plasmonic properties of single nanostructures.
Distributed Bragg reflector based ASE noise removal pump wavelength filters for futuristic chip-scale quantum photonic circuits
Authors: Priyadarshini Pratyasha , Goswami Arnab , Velamuri Ashitosh , Krishna Das Bijoy 
Published: June 2024

This article reports a novel design of a compact tunable resonance filter with a highly extinguished and ultra-broad out-of-band rejection for on-chip amplified spontaneous noise suppression from pump lasers highly demanding for generating pure/entangled photon pairs via χ(3) process in a CMOS compatible silicon photonics technology platform. The proposed device is designed with two identically apodized distributed grating structures for guided Fabry-Perot resonant transmissions in a silicon-on-insulator rib waveguide structure. The device design parameters are optimized by theoretical simulation for a low insertion loss singly-resonant transmission peak at a desired wavelength. We observed that a device length of as low as ∼ 35 µm exhibits a rejection band as large as ∼ 60 nm with an extinction of ∼ 40 dB with respect to the resonant wavelength peak at λ
r
∼ 1550 nm (FWHM ∼ 80 pm, IL ∼ 2 dB). The experimental results have been shown to be closely matching to our theoretical simulation and modeling results in terms of its stop bandwidth and resonance wavelength for noise suppressed pump laser wavelength filtering. As expected from the theoretical prediction, the trend pertaining to the trade-off between passive insertion loss and Q-value of the resonances has been observed depending on the device parameters. The thermo-optic tuning characteristics of resonant wavelengths have been obtained by integrating microheaters. The resonance peak could be tuned at a rate of 96 pm per mW of consumed thermal power. Noise associated with an amplified pump wavelength (λ
P
∼ 1550 nm) has been shown to be suppressed (∼ 40-dB), up to the detector noise floor.