bluuebunny/crossref_metadata_2025_split huggingface dataset:
1,25‐Dihydroxyvitamin D3 alters murine dendritic cell behaviour in vitro and in vivo
Authors: Ferreira Gabriela Bomfim , van Etten Evelyne , Verstuyf Annemieke , Waer Mark , Overbergh Lut , Gysemans Conny , Mathieu Chantal 
Published: November 2011

AbstractBackgroundDifferentiation and maturation of dendritic cells yield a cell type with the ability to prime immune responses towards defence and destruction. 1,25(OH)2D3, the active form of vitamin D3, fosters the development of tolerogenic dendritic cells. This study aimed to evaluate the effects of 1,25(OH)2D3 on murine dendritic cell behaviour in vitro and in vivo.MethodsDendritic cells were differentiated from bone marrow cells of female C57Bl/6 mice in the presence or absence of 10−8 M 1,25(OH)2D3 for 8 days (IL4 and GM‐CSF). Maturation was induced for 48 h (IFNγ, LPS and BALB/C islet homogenate antigen).ResultsBone marrow‐derived dendritic cells displayed a different surface marker profile in the presence of 1,25(OH)2D3 with decreased MHC II, CD86 and CD80 and increased CCR5, DEC205, F4/80 and CD40, as well as lower IL6 and IL12 expression upon LPS/IFNγ stimulation. T‐cell proliferation was significantly reduced when exposed to islet antigen‐loaded 1,25D3‐DCs as compared to control dendritic cells and IL4, IL10, TNFα and TGFβ levels were increased. In vivo, transfer of islet antigen‐loaded control dendritic cells resulted in priming of the immune system and hyperacute islet allograft rejection (4/4), whereas this was prevented in 5/7 mice treated with islet antigen‐loaded 1,25D3‐DCs.ConclusionWe conclude that in vitro 1,25(OH)2D3 exposure alters dendritic cell behaviour, converting them into a cell type that drives T cells away from destruction towards a regulatory phenotype. Copyright © 2011 John Wiley & Sons, Ltd.
Inductive and Mesomeric Effects of the [60]Fulleropyrrolidine Fragment and [60]Fullerene Sphere: A Quantitative Evaluation Based on Theory and Experiments
Authors: Ciogli Alessia , Fontana Antonella , Gasparrini Francesco , Maggini Michele , Giovannoli Mario , Pierini Marco , Busolo Filippo , Siani Gabriella , Villani Claudio 
Published: November 2011

AbstractInductive and mesomeric effects of the [60]fulleropyrrolidine (Pyr=C60) and the [60]fullerene (C60) molecular frameworks have been investigated by linear free energy relationship analyses. The electronic effects of these moieties have been studied by expressly designing [60]fulleropyrrolidine derivative 1, which has a C–H bond α to both a carbonyl group (C–Hα) and a C60 cage. The extent of polarization of such a bond was then used to probe electron‐withdrawing perturbation induced by the fullerene sphere. Thermodynamic measurements based on both theoretical and experimental approaches allowed the acidity of ketone 1 to be measured; this resulted in about a 1 × 106‐fold increase in acidity with respect to that of the structurally correlated acetophenone. Experimental and theoretical kinetic determinations were used to determine the stereolability of ketone 1, which was, in fact, chiral due to the stereogenic carbon α to the carbonyl group. Also, these results confirmed the very strong tendency for the C60 sphere to promote breaking of the C–Hα bond. Thismeans that the Pyr=C60 and C60 fragments are able to express electron‐withdrawing effects stronger than those of halogen atoms, but less effective than those of carbonyl derivatives (e.g., ketones, carboxylic acids or acyl derivatives). Finally, the σp, σI and σR– descriptors of inductive and/or mesomeric effects were successfully estimated for both Pyr=C60 and C60 fragments thanks to the integrated use of an original procedure based on semi‐empirical calculations and Hammett/Taft correlations involving mono‐ or dual‐parameter equations.
Kinetic Resolution of Activated Nitroallylic Acetates with Aldehydes and Ketones through a Conjugate Addition–Elimination SN2′ Process
Authors: Jannapu Reddy Raju , Lee Pei‐Hsun , Magar Dhananjay R. , Chen Jung‐Hsuan , Chen Kwunmin 
Published: November 2011

AbstractA unique organocatalytic kinetic resolution (KR) of nitroallylic acetates has been developed. A variety of racemic nitroallylic acetates (1a–n) were resolved with chiral enamines formed in situ from the reaction of aldehydes and ketones with organocatalyst 2b (2.5 mol‐%) and 14c (20 mol‐%), respectively, through an interesting SN2′ reaction. The densely functionalized products 3–5 were obtained with high to excellent levels of stereoselectivities (up to >99:1 dr and >99 % ee) in good to high chemical yields. The unreactive starting substrates 1a–n were recovered with good to high optical purity (up to 98 % ee). The scope and generality of the kinetic resolution was expanded to include a wide range of nitroallylic acetates with various aldehydes and ketones as the donor sources. The absolute stereochemistry of the functionalized products and the unreacted substrate were determined. Synthetic application was demonstrated when (S)‐citronellal was treated with rac‐1a in the presence of 2b to give 12 as a single diastereomer, which was further cyclized to give a tetrasubstituted cyclohexane derivative 13 with excellent stereoselectivity. Transition‐state models were proposed to account for the stereochemical bias in the KR process.
Substituted Functional Olefins Through Lateral Sequential Lithiation/Silylation/Condensation of Tertiary Aromatic Amides: A Ligand for Phosphane‐Free Palladium‐Catalyzed Suzuki Coupling Reactions
Authors: Xu Li‐Wen , Chen Xi‐Huai , Shen Hao , Deng Yuan , Jiang Jian‐Xiong , Jiang Kezhi , Lai Guo‐Qiao , Sheng Chun‐Qi 
Published: November 2011

AbstractAn unprecedented lateral sequential lithiation/silylation/condensation of tertiary aromatic amides has been developed that provides an efficient method to build up functional olefins in good yields. In addition, we have established an efficient and simple method that involves UV/Vis, fluorescence, and NMR analyses, to detect the interaction between transition‐metal salts and functional olefins containing tertiary amides. This has enabled a highly efficient palladium‐catalyzed Suzuki coupling reaction in the presence of tertiary aromatic amide‐derived olefin ligands to be developed. The best results were obtained by employing 2 mol‐% Pd(OAc)2, 2 equiv. Cs2CO3, a reaction temperature of 80 °C, dioxane as the solvent, and phosphane‐free olefin 2d as ligand.
Influence of carbon fibre orientation on reaction‐to‐fire properties of polymer matrix composites
Authors: Eibl Sebastian 
Published: November 2011

SUMMARYThe influence of the orientation of carbon fibres on the reaction‐to‐fire characteristics of a layered composite has been investigated in detail. 8552/IM7 prepregs were laid up to give unidirectional and quasi‐isotropic laminates. Specimen thickness (0.25 to 8.0 mm) and heat flux (15 to 80 kW/m2) were varied for irradiation. Fundamental reaction‐to‐fire properties of this composite are interpreted on the basis of the matrix components: epoxy resin and polyethersulfone. Cone calorimetry and temperature distributions through the laminate showed that the velocity and degree of combustion are dominated by fibre orientation for a given resin. In general, a quasi‐isotropic fibre orientation leads to faster ignition, because of preferred delaminations, but retards combustion processes more effectively than a unidirectional lay‐up. Migration velocities of the pyrolysis zone were measured. Copyright © 2011 John Wiley & Sons, Ltd.
A Meta‐learning Framework for Bankruptcy Prediction
Authors: Tsai Chih‐Fong , Hsu Yu‐Feng 
Published: November 2011

ABSTRACTThe implication of corporate bankruptcy prediction is important to financial institutions when making lending decisions. In related studies, many bankruptcy prediction models have been developed based on some machine‐learning techniques. This paper presents a meta‐learning framework, which is composed of two‐level classifiers for bankruptcy prediction. The first‐level multiple classifiers perform the data reduction task by filtering out unrepresentative training data. Then, the outputs of the first‐level classifiers are utilized to create the second‐level single (meta) classifier. The experiments are based on five related datasets and the results show that the proposed meta‐learning framework provides higher prediction accuracy rates and lower type I/II errors when compared with the stacked generalization classifier and other three widely developed baselines, such as neural networks, decision trees, and logistic regression. Copyright © 2011 John Wiley & Sons, Ltd.
Regulation of proton‐coupled folate transporter in retinal Müller cells by the antipsoriatic drug monomethylfumarate
Authors: Bozard B. Renee , Chothe Paresh P. , Tawfik Amany , Williams Cory , Fulzele Sadanand , Prasad Puttur D. , Martin Pamela M. , Ganapathy Vadivel , Smith Sylvia B. 
Published: November 2011

AbstractFumaric acid esters are used to treat psoriasis, an inflammatory skin disease characterized by keratinocyte proliferation. Inflammation and proliferation are hallmarks of retinal disease; hence, fumaric acid esters may have therapeutic value in retinal pathology. In diseased retinas, Müller glial cells (MCs) undergo reactive gliosis, a hyperproliferative state. MCs take up folate, a vitamin necessary for cell proliferation, via the proton‐coupled folate transporter (PCFT). Here we examined the effect of monomethylfumarate (MMF), the active metabolite of fumaric acid esters, on expression and function of PCFT in MCs. Primary MCs, isolated from neonatal mouse retinas, were treated with MMF, and PCFT function was monitored by measuring uptake of radiolabeled methyltetrahydrofolate (MTF) at pH 5.5. Dose–response and time‐course analyses were performed to identify optimal conditions for maximal effect. The influence of MMF treatment on kinetic parameters of PCFT was studied, and PCFT expression was analyzed at the mRNA and protein level. MTF uptake in MCs decreased by ˜50% following 18 h treatment with 1 mM MMF. This effect was specific to fumaric acid esters. MMF treatment decreased the maximal velocity of the transporter without altering substrate affinity. The decrease in PCFT function following MMF treatment was accompanied by attenuated PCFT expression. This is the first report that an antipsoriatic compound can regulate folate transport in MCs and may have potential for the treatment of reactive gliosis in retinal disease. © 2011 Wiley Periodicals, Inc.
Multimodal magnetic resonance imaging: The coordinated use of multiple, mutually informative probes to understand brain structure and function
Authors: Hao Xuejun , Xu Dongrong , Bansal Ravi , Dong Zhengchao , Liu Jun , Wang Zhishun , Kangarlu Alayar , Liu Feng , Duan Yunsuo , Shova Satie , Gerber Andrew J. , Peterson Bradley S. 
Published: November 2011

AbstractDiffering imaging modalities provide unique channels of information to probe differing aspects of the brain's structural or functional organization. In combination, differing modalities provide complementary and mutually informative data about tissue organization that is more than their sum. We acquired and spatially coregistered data in four MRI modalities—anatomical MRI, functional MRI, diffusion tensor imaging (DTI), and magnetic resonance spectroscopy (MRS)—from 20 healthy adults to understand how interindividual variability in measures from one modality account for variability in measures from other modalities at each voxel of the brain. We detected significant correlations of local volumes with the magnitude of functional activation, suggesting that underlying variation in local volumes contributes to individual variability in functional activation. We also detected significant inverse correlations of NAA (a putative measure of neuronal density and viability) with volumes of white matter in the frontal cortex, with DTI‐based measures of tissue organization within the superior longitudinal fasciculus, and with the magnitude of functional activation and default‐mode activity during simple visual and motor tasks, indicating that substantial variance in local volumes, white matter organization, and functional activation derives from an underlying variability in the number or density of neurons in those regions. Many of these imaging measures correlated with measures of intellectual ability within differing brain tissues and differing neural systems, demonstrating that the neural determinants of intellectual capacity involve numerous and disparate features of brain tissue organization, a conclusion that could be made with confidence only when imaging the same individuals with multiple MRI modalities. Hum Brain Mapp, 2013. © 2011 Wiley Periodicals, Inc.
Impairment of executive performance after transcranial magnetic modulation of the left dorsal frontal‐striatal circuit
Authors: van den Heuvel Odile A. , Van Gorsel Helene C. , Veltman Dick J. , Van Der Werf Ysbrand D. 
Published: November 2011

AbstractThe dorsal frontal‐striatal circuit is implicated in executive functions, such as planning. The Tower of London task, a planning task, in combination with off‐line low‐frequency repetitive transcranial magnetic stimulation (rTMS), was used to investigate whether interfering with dorsolateral prefrontal function would modulate executive performance, mimicking dorsal frontal‐striatal dysfunction as found in neuropsychiatric disorders. Eleven healthy controls (seven females; mean age 25.5 years) were entered in a cross‐over design: two single‐session treatments of low‐frequency (1 Hz) rTMS (vs. sham rTMS) for 20 min on the left dorsolateral prefrontal cortex (DLPFC). Directly following the off‐line rTMS treatment, the Tower of London task was performed during MRI measurements. The low‐frequency rTMS treatment impaired performance, but only when the subjects had not performed the task before: we found a TMS condition‐by‐order effect, such that real TMS treatment in the first session led to significantly more errors (P = 0.032), whereas this TMS effect was not present in subjects who received real TMS in the second session. At the neural level, rTMS resulted in decreased activation during the rTMS versus sham condition in prefrontal brain regions (i.e., premotor, dorsolateral prefrontal and anterior prefrontal cortices) and visuospatial brain regions (i.e., precuneus/cuneus and inferior parietal cortex). The results show that low‐frequency off‐line rTMS on the DLPFC resulted in decreased task‐related activations in the frontal and visuospatial regions during the performance of the Tower of London task, with a behavioral effect only when task experience is limited. Hum Brain Mapp, 2013. © 2011 Wiley Periodicals, Inc.
Impact of comorbidity on therapeutic decision‐making in head and neck cancer: Audit from a comprehensive cancer center in India
Authors: Baijal Gunjan , Gupta Tejpal , Hotwani Chandni , Laskar Sarbani Ghosh , Budrukkar Ashwini , Murthy Vedang , Agarwal Jai Prakash 
Published: November 2011

AbstractBackgroundHead and neck cancer has increased incidence of comorbidity due to tobacco and alcohol use.MethodsTwo hundred consecutive patients were included in this cross‐sectional study. Data on clinico‐demographic characteristics and comorbidity was extracted from case records. Comorbidity was assessed with Adult Comorbidity Evaluation 27 (ACE‐27) and Charlson Comorbidity Index (CCI). Change in therapeutic decision‐making from institutional evidence‐based guidelines was classified as low, medium, or high‐impact.ResultsOf 200 patients, 68(34%) had comorbidity while 15 had multimorbidity. No change in therapeutic decision‐making was seen in 139 patients (69.5%), 61patients (30.5%) had change from institutional evidence‐based guidelines. There was strong positive correlation (Spearman's correlation coefficient = 0.80; p < .001) between ACE‐27 and change in therapeutic decision‐making. For CCI, there was moderate positive correlation (Spearman's correlation coefficient = 0.50; p < .001).ConclusionComorbidity in patients with head and neck cancer can influence therapeutic decision‐making. Prospective longitudinal rigorous collection of comorbidity data is warranted for correlation with outcomes. ACE‐27 may be a clinically more meaningful tool for comorbidity assessment. © 2011 Wiley Periodicals, Inc. Head Neck, 2012
Detection of circulating tumor cells in advanced head and neck cancer using the cellsearch system
Authors: Nichols Anthony C. , Lowes Lori E. , Szeto Christopher C. T. , Basmaji John , Dhaliwal Sandeep , Chapeskie Corina , Todorovic Biljana , Read Nancy , Venkatesan Varugar , Hammond Alex , Palma David A. , Winquist Eric , Ernst Scott , Fung Kevin , Franklin Jason H. , Yoo John , Koropatnick James , Mymryk Joe S. , Barrett John W. , Allan Alison L. 
Published: November 2011

AbstractBackgroundEarly detection of circulating tumor cells (CTCs) offers the possibility of improved outcome for patients with head and neck squamous cell cancer (HNSCC).MethodsPatients with advanced‐stage HNSCC (stage III/IV) were tested for CTCs using the CellSearch system (a registered trade name), which has been approved by the U.S. Food and Drug Administration (FDA) for monitoring CTCs in other cancers.ResultsCTCs were detected in 6 of 15 patients with advanced‐stage HNSCC (range, 1–2 cells/7.5 mL of blood). CTCs were significantly associated with patients with lung nodules >1 cm (p = .04). There was also a suggestion of improved survival in the CTC‐negative versus the CTC‐positive patients (p = .11).ConclusionsCTCs can be successfully isolated in patients with advanced‐stage HNSCC using the CellSearch system. CTC detection may be important for prognosis, evaluating treatment outcome, and for determining efficacy of adjuvant treatments. © 2011 Wiley Periodicals, Inc. Head Neck, 2011
Projection of glacier runoff in Yarkant River basin and Beida River basin, Western China
Authors: Zhang Shiqiang , Gao Xin , Zhang Xiaowen , Hagemann Stefan 
Published: November 2011

AbstractPotential changes in glacier area, mass balance and runoff in the Yarkant River Basin (YRB) and Beida River Basin (BRB) are projected for the period from 2011 to 2050 employing the modified monthly degree‐day model forced by climate change projection. Future monthly air temperature and precipitation were derived from the simple average of 17, 16 and 17 General Circulation Model (GCM) projections following the A1B, A2 and B1 scenarios, respectively. These data were downscaled to each station employing the Delta method, which computes differences between current and future GCM simulations and adds these changes to observed time series. Model parameters calibrated with observations or results published in the literature between 1961 and 2006 were kept unchanged. Annual glacier runoff in YRB is projected to increase until 2050, and the total runoff over glacier area in 1970 is projected to increase by about 13%–35% during 2011–2050 relative to the average during 1961–2006. Annual glacier runoff and the total runoff over glacier area in 1970 in BRB is projected to increase initially and then to reach a tipping point during 2011–2030. There are prominent increases in summer, but only small increase in May and October of glacier runoff in YRB, and significant increases during late spring and early summer and significant decreases in July and late summer of glacier runoff in BRB. This study highlights the great differences among basins in their response to future climate warming. The specific runoff from areas exposed after glacier retreat relative to 1970 is projected to general increasing, which must be considered when evaluating the potential change of glacier runoff. Copyright © 2011 John Wiley & Sons, Ltd.
Dietary total antioxidant capacity and gastric cancer risk in the European prospective investigation into cancer and nutrition study
Authors: Serafini Mauro , Jakszyn Paula , Luján‐Barroso Leila , Agudo Antonio , Bas Bueno‐de‐Mesquita H. , van Duijnhoven Fränzel J.B. , Jenab Mazda , Navarro Carmen , Palli Domenico , Boeing Heiner , Wallström Peter , Regnér Sara , Numans Mattijs E. , Carneiro Fatima , Boutron‐Ruault Marie‐Christine , Clavel‐Chapelon Françoise , Morois Sophie , Grioni Sara , Panico Salvatore , Tumino Rosario , Sacerdote Carlotta , Ramon Quirós José , Molina‐Montes Esther , Huerta Castaño Jose M. , Barricarte Aurelio , Amiano Pilar , Khaw Kay‐Tee , Wareham Nicholas , Allen Naomi E. , Key Timothy J. , Jeurnink Suzanne M. , Peeters Petra H.M. , Bamia Christina , Valanou Elisabeth , Trichopoulou Antonia , Kaaks Rudolf , Lukanova Annekatrin , Bergmann Manuela M. , Lindkvist Björn , Stenling Roger , Johansson Ingegerd , Dahm Christina C. , Overvad Kim , Jensen Majken , Olsen Anja , Tjonneland Anne , Lund Eiliv , Rinaldi Sabina , Michaud Dominique , Mouw Traci , Riboli Elio , González Carlos A. 
Published: November 2011

AbstractA high intake of dietary antioxidant compounds has been hypothesized to be an appropriate strategy to reduce gastric cancer (GC) development. We investigated the effect of dietary total antioxidant capacity (TAC) in relation to GC in the European Prospective Investigation into Cancer (EPIC) study including 23 centers in 10 European countries. A total of 521,457 subjects (153,447 men) aged mostly 35–70 years old, were recruited largely between 1992 and 1998. Ferric reducing antioxidant potential (FRAP) and total radical‐trapping antioxidant parameter (TRAP), measuring reducing and chain‐breaking antioxidant capacity were used to measure dietary TAC from plant foods. Dietary antioxidant intake is associated with a reduction in the risk of GC for both FRAP (adjusted HR 0.66; 95%CI (0.46–0.95) and TRAP (adjusted HR 0.61; 95%CI (0.43–0.87) (highest vs. lowest quintile). The association was observed for both cardia and noncardia cancers. A clear effect was observed in smokers with a significant reduction in GC risk for the fifth quintile of intake for both assays (highest vs. lowest quintile: adjusted HR 0.41; 95%CI (0.22–0.76) p for trend <0.001 for FRAP; adjusted HR 0.52; 95%CI (0.28–0.97) p for trend <0.001 for TRAP) but not in nonsmokers. In former smokers, the association with FRAP intake was statistically significant (highest vs. lowest quintile: adjusted HR 0.4; 95%CI (0.21–0.75) p < 0.05); no association was observed for TRAP. Dietary antioxidant capacity intake from different sources of plant foods is associated with a reduction in the risk of GC.