bluuebunny/crossref_metadata_2025_split huggingface dataset:
Reported zinc, but not copper, intakes influence whole-body bone density, mineral content and T score responses to zinc and copper supplementation in healthy postmenopausal women
Authors: Nielsen Forrest H. , Lukaski Henry C. , Johnson LuAnn K. , Roughead Z. K. (Fariba) 
Published: July 2011

A supplementation trial starting with 224 postmenopausal women provided with adequate vitamin D and Ca was conducted to determine whether increased Cu and Zn intakes would reduce the risk for bone loss. Healthy women aged 51–80 years were recruited for a double-blind, placebo-controlled study. Women with similar femoral neck T scores and BMI were randomly assigned to two groups of 112 each that were supplemented daily for 2 years with 600 mg Ca plus maize starch placebo or 600 mg Ca plus 2 mg Cu and 12 mg Zn. Whole-body bone mineral contents, densities and T scores were determined biannually by dual-energy X-ray absorptiometry, and 5 d food diaries were obtained annually. Repeated-measures ANCOVA showed that bone mineral contents, densities and T scores decreased from baseline values to year 2. A priori contrasts between baseline and year 2 indicated that the greatest decreases occurred with Cu and Zn supplementation. Based on 5 d food diaries, the negative effect was caused by Zn and mainly occurred with Zn intakes ≥ 8·0 mg/d. With Zn intakes < 8·0 mg/d, Zn supplementation apparently prevented a significant decrease in whole-body bone densities and T scores. Food diaries also indicated that Mg intakes < 237 mg/d, Cu intakes < 0·9 mg/d and Zn intakes < 8·0 mg/d are associated with poorer bone health. The findings indicate that Zn supplementation may be beneficial to bone health in postmenopausal women with usual Zn intakes < 8·0 mg/d but not in women consuming adequate amounts of Zn.
On a refinement of the 13C-mixed TAG breath test
Authors: Bożek Małgorzata , Jonderko Krzysztof , Piłka Monika 
Published: July 2011

The present study was aimed to improve and simplify the 13C-mixed TAG (13C-MTG) breath test while keeping it acceptable for the patient. Healthy volunteers (ten women and eight men) were examined on four occasions, receiving in a random order 300 mg 13C-MTG: (1) contained in two wafers; (2) administered with a 50 g wheat roll; as well as given with either (3) 10 or (4) 30 g butter, spread onto a 50 g wheat roll, as the test meal, respectively. Samples of expiratory air were taken for 6 h postprandially for the mass spectroscopic measurement of 13CO2 enrichment. After intake of the sole 13C-MTG, the cumulative 13C recovery in breath air (AUC) appeared to be unsatisfactory, as after 6 h it did not exceed 10 %. Application of the substrate with the 50 g wheat roll did not bring about any improvement in this parameter. The addition of the unlabelled fat to the test meal dramatically increased the cumulative 13C recovery. However, we found higher values for the momentary 13C recovery and AUC with 10 g butter compared with 30 g. It can be concluded that: (1) addition of unlabelled fat is indispensable to obtain a proper course of the breath 13C elimination during the conduct of the 13C-MTG breath test and (2) it is possible to apply a considerably smaller amount of the unlabelled fat than has previously been recommended for this test.
Effects of short-term feeding of Bt MON810 maize on growth performance, organ morphology and function in pigs
Authors: Walsh Maria C. , Buzoianu Stefan G. , Gardiner Gillian E. , Rea Mary C. , Paul Ross R. , Cassidy Joseph P. , Lawlor Peadar G. 
Published: July 2011

Male weanling pigs (n32) with a mean initial body weight of 7·5 kg and a mean weaning age of 28 d were used in a 31 d study to investigate the effects of feeding GM (Bt MON810) maize on growth performance, intestinal histology and organ weight and function. At weaning, the pigs were fed a non-GM starter diet during a 6 d acclimatisation period. The pigs were then blocked by weight and litter ancestry and assigned to diets containing 38·9 % GM (Bt MON810) or non-GM isogenic parent line maize for 31 d. Body weight and feed disappearance were recorded on a weekly basis (n16/treatment), and the pigs (n10/treatment) were killed on day 31 for the collection of organ, tissue and blood samples. GM maize-fed pigs consumed more feed than the control pigs during the 31 d study (P < 0·05) and were less efficient at converting feed to gain during days 14–30 (P < 0·01). The kidneys of the pigs fed GM maize tended to be heavier than those of control pigs (P = 0·06); however, no histopathological changes or alterations in blood biochemistry were evident. Small intestinal morphology was not different between treatments. However, duodenal villi of GM maize-fed pigs tended to have fewer goblet cells/μm of villus compared with control pigs (P = 0·10). In conclusion, short-term feeding of Bt MON810 maize to weaned pigs resulted in increased feed consumption, less efficient conversion of feed to gain and a decrease in goblet cells/μm of duodenal villus. There was also a tendency for an increase in kidney weight, but this was not associated with changes in histopathology or blood biochemistry. The biological significance of these findings is currently being clarified in long-term exposure studies in pigs.
THE WATER RELATIONS AND IRRIGATION REQUIREMENTS OF OIL PALM (ELAEIS GUINEENSIS): A REVIEW
Authors: CARR M. K. V. 
Published: July 2011

SUMMARYThe results of research on the water relations and irrigation need of oil palm are collated and summarized in an attempt to link fundamental studies on crop physiology to drought mitigation and irrigation practices. Background information is given on the centres of origin (West Africa) and of production of oil palm (Malaysia and Indonesia), but the crop is now moving into drier regions. The effects of water stress on the development processes of the crop are summarized followed by reviews of its water relations, water use and water productivity. The majority of the recent research published in the international literature has been conducted in Malaysia and in Francophone West Africa. The unique vegetative structure of the palm (stem and leaves) together with the long interval between flower initiation and the harvesting of the mature fruit (ca. three years) means that causal links between environmental factors (especially water) and yield are difficult to establish. The majority of roots are found in the 0–0.6 m soil horizons, but roots can reach depths greater than 5 m and spread laterally up to 25 m from the trunk. The stomata are a sensitive indicator of plant water status and play an important role in controlling water loss. Stomatal conductance and photosynthesis are negatively correlated with the saturation deficit of the air. It is not easy to measure the actual water use of oil palm, the best estimates for mature palms suggesting crop evapotranspiration (ETc) rates of 4–5 mm d−1in the monsoon months (equivalent to 280–350 l palm−1d−1). For well-watered mature palms, crop coefficient (Kc) values are in the range 0.8–1.0. Although the susceptibility of oil palm to drought is well recognized, there is a limited amount of reliable data on actual yield responses to irrigation. The best estimates are 20–25 kg fresh fruit bunches ha−1mm−1(or a yield loss of about 10% for every 100 mm increase in the soil water deficit). These increases are only realized in the third and subsequent years after the introduction of irrigation and follow an increase in the number of fruit bunches as a result of an improvement in the sex ratio (female/total inflorescence production) and a reduction in the abortion of immature inflorescences. There is no agreement on the allowable depletion of the available soil water, or on the associated optimum irrigation interval. Drip irrigation has been used successfully on oil palm.
CoLoR: a Coq library on well-founded rewrite relations and its application to the automated verification of termination certificates
Authors: BLANQUI FRÉDÉRIC , KOPROWSKI ADAM 
Published: July 2011

Termination is an important property of programs, and is notably required for programs formulated in proof assistants. It is a very active subject of research in the Turing-complete formalism of term rewriting. Over the years, many methods and tools have been developed to address the problem of deciding termination for specific problems (since it is undecidable in general). Ensuring the reliability of those tools is therefore an important issue.In this paper we present a library formalising important results of the theory of well-founded (rewrite) relations in the proof assistant Coq. We also present its application to the automated verification of termination certificates, as produced by termination tools.The sources are freely available athttp://color.inria.fr/.
Preface
Authors: HUET GÉRARD 
Published: July 2011

This special issue of Mathematical Structures in Computer Science is devoted to the theme of ‘Interactive theorem proving and the formalisation of mathematics’.The formalisation of mathematics started at the turn of the 20th century when mathematical logic emerged from the work of Frege and his contemporaries with the invention of the formal notation for mathematical statements called predicate calculus. This notation allowed the formulation of abstract general statements over possibly infinite domains in a uniform way, and thus went well beyond propositional calculus, which goes back to Aristotle and only allowed tautologies over unquantified statements.
Effect of melatonin treatment on the developmental potential of parthenogenetic and somatic cell nuclear-transferred porcine oocytesin vitro
Authors: Nakano Mayu , Kato Yoko , Tsunoda Yukio 
Published: July 2011

SummaryMelatonin secreted from the mammalian pineal gland is a free-radical scavenger that protects tissues from cell damage. The present study examined the effects of addition of melatonin to the culture medium on the developmental potential of parthenogenetic and somatic cell nuclear-transferred (SCNT) porcine oocytes. Supplementation of the maturation medium with melatonin did not increase the maturation rate, the proportion of oocytes that cleaved and developed into blastocysts after parthenogenetic activation, or the blastocyst cell number compared to controls. When 10−7M melatonin was added to the culture medium, the proportion of parthenogenetic oocytes that developed to the 2-cell and 4-cell stages was significantly higher than that of controls. The potential of melatonin-treated oocytes to develop into blastocysts was high but not significantly different from that of controls. The addition of 10−7M melatonin to the culture medium did not increase the preimplantation development of SCNT oocytes. Melatonin treatment significantly reduced the levels of reactive oxygen species in 4-cell parthenogenetic and SCNT embryos, but did not reduce the proportion of apoptotic cells in parthenogenetic and SCNT blastocysts. Although the results indicated that parthenogenetic and SCNT melatonin -treated embryos had significantly lower levels of reactive oxygen species than controls, the potential of melatonin-treated embryos to develop into blastocysts was not significantly higher than that of controls, in contrast to previous reports. The beneficial effects of melatonin on the developmental potential of oocytes might depend on the culture conditions.
Levels of lipoprotein (a) in pulmonary arterial hypertension
Authors: Santos Raul D. , Foronda Antonio , Ramires José A. F. , Maranhão Raul C. 
Published: July 2011

AbstractWe compared the levels of lipoprotein (a) in 48 Caucasian patients with pulmonary arterial hypertension, comprising 32 females and 16 males, aged 28.0 ± 12.0 years, with a range from 4 through 52 years, with 48 normal Caucasian subjects matched for age and sex. Pulmonary hypertension was secondary in 41 patients with Eisenmenger's syndrome, these comprising 27 females and 14 males aged 27.0 ± 12.0 years, with a range from 4 through 51 years, and primary in the other 7 patients, 5 females and 2 males, whose age was 30.0 ± 14.0 years, with a range from 9 through 52 years. Lipoprotein (a) was measured using an immunoprecipitation and turbidimetric assay after a 12 hour fast. Levels of the protein, expressed as the median (% 25; % 75), were higher in those with Eisenmenger's syndrome than in normal controls (p = 0.003). In addition, there was a greater prevalence of levels of lipoprotein greater than 30.0 mg/dl in those with secondary pulmonary arterial hypertension patients than in our normal population (p = 0.03). We have found no differences, however, in the levels of lipoprotein(a) in those who had primary pulmonary arterial hypertension when compared with their matched controls, albeit that the number of patients studied was small. We conclude that increased levels of lipoprotein (a) may be secondary to pulmonary arterial hypertension as a marker of tissue damage or may be genetically determined. In either way, the increase in lipoprotein (a) could be an additional factor predisposing to the vascular alterations known to occur in this disease.
Balloon dilation for aortic recoarctation: morphology at the site of dilation and long-term efficacy
Authors: Mann Christian , Goebel Georg , Eicken Andreas , Genz Thomas , Sebening Walter , Kaemmerer Harald , Hammerer Ignaz , Hess John 
Published: July 2011

AbstractObjectives: We undertook this study to assess the immediate and long-term outcome of balloon angioplasty performed for recurrent or residual coarctation of the aorta, and to assess the changes in the vessel wall caused by this procedure.Methods: Clinical, echocardiographic, angiographic and hemodynamic data from 71 patients who underwent balloon angioplasty for recoarctation between January 1987 and January 1998 were analysed retrospectively.Results: Angioplasty was performed after a median of 82.6 months (range 1.4 mo – 20.9 y, mean 88.5 mo) following surgery for coarctation. Mean systolic pressure gradients were reduced from 27±15 mmHg to 11 ± 11 m m Hg after angioplasty (p< 0.0001). The mean diameter at the site of recoarctation increased from 5.5±2.5 to 7.5±2.7 mm(p< 0.0001). Outpouchings of contrast agents, indicating the disruption of the inner layers of the vessel wall, were defined as extravasations. They were observed in one-quarter of the angiograms performed immediately after the intervention. Immediate success of angioplasty was achieved in 71%, and persisted in 69% of patients during long-term follow up. The main determinant for immediate success was the age at the time of the procedure (p<0.05), while the main determinant for long-term success was the increase achieved in diameter. Extravasations did not progress to aneurysms, neither acutely nor during echocardiographic follow-up studies. For further follow-up, more sensitive imaging techniques will be necessary to delineate the morphology of the site of extravasation observed immediately after angioplasty.
Cytokines and pediatric open heart surgery with cardiopulmonary bypass
Authors: Carvalho Marcus V. H. , Maluf Miguel A. , Catani Roberto , Rotta Carlos A. A. La , Gomes Walter J. , Salomão Reinaldo , da Silva Célia M. , Carvalho Antonio C.C. , Branco João N. R. , Buffolo Enio 
Published: July 2011

AbstractIt is well known that, subsequent to cardiopulmonary bypass, and particularly in children, an inflammatory response within the body can often result in a characteristic syndrome. Recently, it has been suggested that this phenomenon is due to a systemic inflammatory response, with significant involvement of cytokines. With this in mind, we investigated the behavior of tumour necrosis factor-α and interleukin–6 during the operative and in the immediate postoperative period in a group of children submitted to open heart surgery. We investigated any possible relation between the levels of these cytokines in the serum and the length of cardiopulmonary bypass, with the serum levels of lactate, and with the extent of use of inotropic drugs in postoperative period. The cytokines were measured in samples withdrawn after induction of anesthesia, after 10 minutes of cardiopulmonary bypass, after re-establishment of circulation, and then 2 and 24 hours after the end of cardiopulmonary bypass. The levels of tumour necrosis factor-α and interleukin–6 increased between the beginning and at two hours of the end of cardiopulmonary bypass. There was no correlation between the levels of these cytokines in the serum and the length of cardiopulmonary bypass, although there was a positive relation between levels of interleukin–6 and lactate in samples withdrawn at two hours of the end of bypass, and the measured levels of the cytokines correlated with the extent of inotropic drugs employed in the postoperative period.
The risk of having additional obstructive lesions in neonatal coarctation of the aorta
Authors: Levine Jami C. , Sanders Stephen P. , Colan Steven D. , Jonas Richard A. , Spevak Philip J. 
Published: July 2011

AbstractInfants with coarctation of the aorta may have obstructions at other sites within the left heart which are not always apparent on the initial echocardiogram. The magnitude of the risk of having the additional obstructions is not well described, with few reliable quantitative criterions for identifying patients at the highest risk. We determined the frequency of additional, late appearing, stenotic lesions within the left heart, and the predictive morphologic features on the initial cross-sectional echocardiogram.We identified all patients with coarctation of the aorta diagnosed by 3 months of age, excluding those with complex cardiac disease or definite additional stenotic lesions at presentation, leaving 101 patients for study. At follow-up, 31 stenotic lesions were diagnosed in 23 patients, 15 of whom had at least 1 intervention. Mitral stenosis was diagnosed in 11 patients, aortic stenosis in 10, subaortic stenosis in 8, and supravalvar aortic stenosis in 2. The probability for freedom from obstructive lesions was 81% at 1 year, 74% at 3 years, and 70% at 5 years. Echocardiographic predictors of mitral stenosis included smaller mitral valvar annuluses, presence of a mean transmitral gradient between 2.5 and 5.0 mmHg, and elongation of the area of intervalvar fibrous continuity. Predictors of aortic stenosis were smaller mitral valvar annuluses, an initial aortic valvar gradient between 15 and 20 mmHg, and obliteration of the commissure between the right and non-coronary leaflets of the aortic valve. Predictors of subaortic stenosis were smaller mitral valvar annuluses and elongation of the area of intervalvar fibrous continuity. Patients with Z-scores for the diameter of the mitral valve of less than −1 were at the highest risk for manifesting obstructive lesions at any level.Associated stenoses in the left heart are common in the setting of aortic coarctation. When Doppler data is equivocal, features of the cross-sectional echocardiogram can identify the sub-group of infants at increased risk.
Postpericardiotomy syndrome: no evidence for a viral etiology
Authors: Webber Steven A. , Wilson Nigel J. , Junker Anne K. , Byrne Sean K. , Perry Angela , Thomas Eva E. , Book Laura , Tipple Marion , Patterson Michael W H , Sandor George G.S. 
Published: July 2011

AbstractBackground: Postpericardiotomy syndrome has been considered a disorder induced by viral infection. This conclusion is based on serologic criterions, but these may be unreliable following either cardiopulmonary bypass or transfusion therapy. Previous studies have not verified the proposed etiology either by isolation of viruses, or by detection of their genome. We sought, therefore, to clarify the role, if any, of viruses in this syndrome.Methods and Results: We studied prospectively 149 children aged from 6 months to 16 years who were undergoing open heart surgery. Blood samples were collected from all prior to operation, and again 7 to 10 days post-operatively, and 47 were sampled at the time of development of symptoms of pericardial involvement. Serums were analyzed for the presence of IgM and IgG antibodies to cytomegalovirus, herpes simplex virus, and Epstein-Barr virus. The polymerase chain reaction was used for amplification when assessing the genome of the enteroviruses. Cultures for viruses were established on samples of stool, urine, and throat swabs collected 7 days post-operatively, and at the time of postpericardial symptoms. Pericardial fluid obtained from 5 patients with the syndrome was cultured for viruses, and tested for enterovirus genome. On the basis of clinical and echocardiographic findings, 34 children were determined to have definite evidence of the syndrome, 13 were considered to have possible evidence, and the results from these patients were compared to those from patients with no pericardial symptoms, the latter being matched for age and transfusion status. We isolated viruses from one or more sites in five patients with definite evidence (16%), from one (9%) of those with possible evidence, and from seven (19%) of the controls. All serums and pericardial samples were negative for enterovirus genome. IgM antibodies were found in only 5 patients, three with symptoms of pericardial involvement and two without. Rates of seroconversion to IgG for the viruses were lower in the patients with symptoms of pericardial involvement compared to controls, but were strongly influenced by transfusion status.Conclusion: Our study has provided no evidence to support a viral etiology for the postpericardiotomy syndrome.
Left ventricular function before and after repair of an anomalous left coronary artery arising from the pulmonary trunk
Authors: Mertens Luc , Weidemann Frank , Sutherland George R. 
Published: July 2011

AbstractWe report an infant with an abnormal left coronary artery arising from the pulmonary trunk in whom, subsequent to surgical repair, sequential improvements in regional left and right systolic and diastolic myocardial function were quantified by the new ultrasound-based method of regional strain and strain rate imaging. The regional radial and longitudinal myocardial function of the left ventricle was homogeneously reduced prior to repair, while the time course of their recovery differed subsequent to repair. We discuss the concepts and advantages behind this quantitative approach to monitoring regional myocardial function in children.
Coarctation co-existing with tetralogy of Fallot and pulmonary atresia
Authors: Yip R.C.W , Deekollu D. , Arnold Robert 
Published: July 2011

AbstractWe describe the finding of unsuspected aortic coarctation, discovered by catheterisation at 4 months, in a neonate first daignosed on the fourth day of life as having tetralogy of Fallot with pulmonary atresia and major aorto-to-pulmonary collateral arteries. This previously unreported combination contravenes the established theory of patterns of flow during fetal life, and presented difficult issues in clinical management.
Replacement of the mitral valve in an infant with group B streptococcal endocarditis
Authors: Walker Thomas A. , Aru Giorgio M. , Ebeid Makram R. 
Published: July 2011

AbstractEndocarditis due to group B streptococcus is very rare in infants, and may be associated with significant morbidity and mortality. Review of the literature reveals only a single reported case of an infant with this type of streptococcal endocarditis involving the mitral valve. This infant had underlying congenital heart disease, and died shortly after catheterization. We now report group B streptococcal endocarditis occurring in an infant with a structurally normal heart who was treated successfully by replacement of the mitral valve.