bluuebunny/crossref_metadata_2025_split huggingface dataset:
Assessment of Platelet Function on Whole Blood by Multiple Electrode Aggregometry in High-Risk Patients With Coronary Artery Disease Receiving Antiplatelet Therapy
Authors: Paniccia Rita , Antonucci Emilia , Maggini Niccolò , Romano Eloisa , Gori Anna Maria , Marcucci Rossella , Prisco Domenico , Abbate Rosanna 
Published: May 2009

Abstract
This study sought to compare Multiplate impedance platelet aggregometry (IPA) with light transmission aggregometry (LTA) and the PFA-100 for determining the prevalence of residual platelet reactivity (RPR) by the Multiplate IPA in 297 patients with acute coronary syndrome receiving dual antiplatelet therapy. Aggregations were induced by adenosine-5 diphosphate (ADP), arachidonic acid, and collagen. PFA-100 closure times were measured by collagen and ADP and epinephrine (CEPI) cartridges. Significant correlations were observed between Multiplate IPA and LTA after all stimulations (P &lt; .0001) and between Multiplate IPA (arachidonate and collagen) and PFA-100 CEPI closure time (P &lt; .0001 for both). Cutoff values of Multiplate IPA (for all stimulations) were calculated for the identification of RPR. Between the Multiplate IPA and LTA good agreement was found with all 3 agonists (P &lt; .0001 for all). Multiplate IPA might represent a reliable, handy, rapid tool to monitor antiplatelet therapy in clinical practice and for clinical investigations.
The Effect of Argatroban on Activated Protein C Resistance
Authors: Shaikh Salima , Van Cott Elizabeth M. 
Published: May 2009

Abstract
Activated protein C (APC) resistance is commonly tested in hypercoagulation evaluations, and argatroban is an anticoagulant therapy used in hypercoagulable patients. The effect of argatroban on APC resistance testing is unknown. We studied 100 ex vivo specimens from 44 patients treated with argatroban. Argatroban increased the APC resistance ratio in all but 1 patient. The effect was seen even in the specimens containing subtherapeutic argatroban levels. For patients without APC resistance, the mean APC resistance ratio significantly increased from 2.43 without argatroban to 3.10 with argatroban. For patients with APC resistance due to factor V Leiden, argatroban significantly increased the mean ratio from 1.73 to 2.13, falsely raising it into the normal range (&gt;2). Argatroban increases the APC resistance ratio, which can mask a diagnosis of APC resistance and, therefore, factor V Leiden. Clinicians should be advised that APC resistance testing for patients receiving argatroban is not valid.
Effect of Soy Extract Administration on Losartan Pharmacokinetics in Healthy Female Volunteers
Authors: Wang Guo , Xiao Chang-Qiong , Li Zhi , Guo Dong , Chen Yao , Fan Lan , Qian Rong-Hua , Peng Xiu-Juan , Hu Dong-Li , Zhou Hong-Hao 
Published: May 2009

BackgroundLosartan is metabolized by CYP2C9 and CYP3A4 to an active metabolite, E-3174, which has greater antihypertensive activity than the parent compound. Soy extract has been shown to be an activator of CYP2C9 and CYP3A4 in vitro. Coadministration of soy extract and losartan may therefore after the pharmacokinetics of losartan and E-3174.ObjectiveTo determine whether, when losartan was used in combination with soy extract, a significant pharmacokinetic interaction would be observed in healthy female volunteers.MethodsEighteen healthy Chinese female volunteers were recruited. In an open-label, 2-phase study, losartan 50 mg was given to each subject, with and without soy extract. Plasma concentrations of losartan and E-3174 were determined by liquid chromatography–tandem mass spectrometry for 12 and 24 hours, respectively. On day 8 through day 21 of the study, following a 7-day washout period, each subject consumed two 1000-mg Genistein Soy Complex tablets orally after meals, twice daily, for 14 days. On day 22, all volunteers received losartan 50 mg and blood samples were collected again.ResultsAll subjects completed the study, without adverse drug effects. Over the 14-day pretreatment period, soy extract did not significantly influence the pharmacokinetics of losartan or E-3174. The ratio of the area under the curve of the drug and metabolite after losartan administration, with and without soy extract ingestion, was 0.21 ± 0.05 and 0.23 ± 0.05 (mean ± SD), respectively. The difference was not statistically significant (p = 0.22).ConclusionsOur data indicate that a significant interaction between soy extract and losartan is unlikely to occur in females.
Swelling behavior of Na- and Ca-montmorillonite up to 150°C by in situ X-Ray diffraction experiments
Authors: Morodome Shoji , Kawamura Katsuyuki 
Published: May 2009

AbstractThe effects of temperature on the swelling properties of smectites are important for a variety of different geological conditions, but studies on this topic have been rather limited. The purpose of this study was to investigate the swelling behavior of Na- and Ca-montmorillonite at various temperatures greater than room temperature, up to 150°C, using in situ X-ray diffraction (XRD) analysis. A sample chamber was designed, the temperature and humidity of which were controlled precisely, for environmental in situ measurements. The XRD measurements were performed at small relative humidity (RH) intervals for precise observation of the swelling behavior.The swelling behavior of Na-montmorillonite showed distinct zero-, one-, and two-layer hydration states. The basal spacings of Na-montmorillonite changed continuously with RH for various temperatures in the transition region between the zero- and one-layer hydration states, and the swelling curves of the transition region moved to greater degrees of RH with increasing temperature. The basal spacings jumped from the one- to two-layer hydration states for all temperatures at almost the same RH.The basal spacings of Ca-montmorillonite changed continuously from the zero- to the two-layer hydration states at all temperatures. This behavior is remarkably different from that of Na-montmorillonite. At low-RH conditions, the d001 value of Ca-montmorillonite decreased with increasing temperature. The swelling curves of Ca-montmorillonite did not show a plateau at any temperature for the one-layer hydration state. The swelling curves of Ca-montmorillonite moved to greater RH with temperature, similar to the transformation region between the zero- and one-layer hydration states in Na-montmorillonite. These differences between Na- and Ca-montmorillonite are related to the hydration powers of exchangeable cations.
Interlayer conformations of intercalated dodecyltrimethylammonium in rectorite as determined by FTIR, XRD, and TG analyses
Authors: Li Zhaohui , Jiang Wei-Teh 
Published: May 2009

AbstractIntercalation of a wide variety of alkylammonium cations into the interlayer spaces of swelling clay minerals leads to many different applications, ranging from surface-charge measurements to rendering the clay compatible for the preparation of clay nanocomposites, but knowledge of the exact conformation of the intercalated organic species is still incomplete, thus preventing a full understanding of this process. The purpose of this study was to investigate the interlayer conformation of dodecyltrimethylammonium (DDTMA) bromide in rectorite as affected by the amounts of DDTMA intercalated, using a battery of physical and spectroscopic methods. The capacity of rectorite to intercalate DDTMA was equivalent to 1.67 times the cation exchange capacity (1.67 CEC) of the mineral even though the initial input was as much as 5.00 CEC. When the DDTMA intercalated was <0.50 CEC of the mineral, minimal counterion sorption was associated with DDTMA intercalation. Derivative thermogravimetric (DTG) analyses revealed a single-peak decomposition temperature (Tpeak) at 430°C. X-ray diffraction (XRD) analyses indicated a flat-lying monolayer of the intercalated molecules, while shifts in Fourier Transform infrared (FTIR) bands confirmed gauche conformation. These results suggested that cation exchange was the dominant mechanism. At the maximum intercalation, the DDTMA adopted a horizontal trilayer arrangement with mainly gauche conformation as determined by FTIR and XRD. Meanwhile a second Tpeak appeared at 255°C, similar to the Tpeak of solid DDTMA. Counterion bromide sorption accompanying DDTMA intercalation reached a capacity of 310 mmol/kg. The results indicated that van der Waals interaction was responsible for the DDTMA uptake at the amount beyond 0.50 CEC. When the amount of DDTMA intercalated was between 0.5 and 1.67 CEC, the XRD patterns showed non-integrality, i.e. the 002 reflection was split into two non-integral peaks with 2 × d002 < d001 and 3 × d003 > d001. They became integral at 1.67 CEC. The results suggest that the mineral might be composed of mixed layers of a monolayer intercalated rectorite and a trilayer intercalated rectorite, without a bilayer as intermediate, when the amount of DDTMA intercalated was between 0.5 and 1.67 CEC.
Bacteria-clay interaction: Structural changes in smectite induced during biofilm formation
Authors: Alimova Alexandra , Katz A. , Steiner Nicholas , Rudolph Elizabeth , Wei Hui , Steiner Jeffrey C. , Gottlieb Paul 
Published: May 2009

AbstractBacteria play an important role in determining the properties and behavior of clay minerals in natural environments and such interactions have great potential for creating stable biofilms and carbon storage sites in soils, but our knowledge of these interactions are far from complete. The purpose of this study was to understand better the effects of bacteria-generated biofilms on clay interlayer expansion. Mixtures of a colloidal, 2-water hectorite clay and Pseudomonas syringae in a minimal media suspension evolve into a polysaccharide-rich biofilm aggregate in time-series experiments lasting up to 1 week. X-ray diffraction analysis reveals that upon aggregation, the clay undergoes an initial interlayer contraction. Short-duration experiments, up to 72 h, result in a decrease in the d001 value from 1.50 to 1.26 nm. The initial interlayer contraction is followed in long-duration (up to 1 week) experiments by an expansion of the d001 value of 1.84 nm. The expansion is probably a result of large, biofilm-produced, polymeric molecules being emplaced in the interlayer site. The resultant organo-clay could provide a possible storage medium for carbon in a microbial colony setting.
Development and validation of the Supervisory Relationship Questionnaire (SRQ) in UK trainee clinical psychologists
Authors: Palomo Marina , Beinart Helen , Cooper Myra J. 
Published: May 2009

Objective. To develop a valid and reliable measure of the supervisory relationship (SR) from the supervisee perspective.Design. A cross‐sectional questionnaire design was used with a repeated measures component for a sub‐sample.Method. Qualitative data obtained from a previous study and from review of the literature were used to construct a 111 item self‐report questionnaire measure [Supervisory Relationship Questionnaire (SRQ)]. This was administered to 284 British trainee clinical psychologists. Eighty‐five participants completed the SRQ a second time to establish its test–retest reliability.Results. Principal components analysis (PCA) identified six components of the SRQ. Three of these reflected the ‘facilitative’ relationship characteristics of the SR and were labelled ‘safe base’, ‘commitment’ and ‘structure’. The second set of components reflected the educative and evaluative functions of supervision. These were labelled ‘reflective education’, ‘role model’ and ‘formative feedback’. Safe base accounted for the greatest proportion of variance in SRQ scores (52 per cent). Analyses using the six subscales subsequently derived from the PCA, revealed the SRQ to have high internal reliability, good test–retest reliability and good construct (convergent and divergent) validity. A preliminary test of predictive validity was conducted.Conclusions. The SRQ (six subscales, total of 67 items) is a valid and reliable measure of the SR from the supervisee perspective. The present findings support existing models of the SR, and its distinct nature during training as an educative and evaluative process. The SRQ is a promising tool for further research, and is likely to be useful in supervisor training and clinical settings.
Job loss and health in the U.S. labor market
Authors: Strully Kate W. 
Published: May 2009

Abstract
While U.S. unemployment rates remain low, rates of job loss are high and rising. Job loss is also becoming increasingly common in more advantaged, white-collar occupations. This article is concerned with how these patterns impact the health of U.S. workers. Drawing on recent data from the U.S. Panel Study of Income Dynamics, I find that job loss harms health, beyond sicker people being more likely to lose their jobs. Respondents who lost jobs but were reemployed at the survey faced an increased risk of developing new health conditions; they were not, however, more likely to describe their health in negative terms. This suggests that recent job “churning” within the United States (i.e., high rates of job loss but low unemployment) may impact certain health outcomes but not others. I find no evidence that the health consequences of job loss differ across white- and blue-collar occupations, although health-related selection out of jobs appears stronger within the blue-collar category.
Unwed fathers’ ability to pay child support: New estimates accounting for multiple-partner fertility
Authors: Sinkewicz Marilyn , Garfinkel Irwin 
Published: May 2009

AbstractWe present new estimates of unwed fathers’ ability to pay child support. Prior research relied on surveys that drastically undercounted nonresident unwed fathers and provided no link to their children who lived in separate households. To overcome these limitations, previous research assumed assortative mating and that each mother partnered with one father who was actually eligible to pay support and had no other child support obligations. Because the Fragile Families and Child Wellbeing Study contains data on couples, multiple-partner fertility, and a rich array of other previously unmeasured characteristics of fathers, it is uniquely suited to address the limitations of previous research. We also use an improved method of dealing with missing data. Our findings suggest that previous research overestimated the aggregate ability of unwed nonresident fathers to pay child support by 33% to 60%.
Parental imprisonment, the prison boom, and the concentration of childhood disadvantage
Authors: Wildeman Christopher 
Published: May 2009

Abstract
Although much research has focused on how imprisonment transforms the life course of disadvantaged black men, researchers have paid little attention to how parental imprisonment alters the social experience of childhood. This article estimates the risk of parental imprisonment by age 14 for black and white children born in 1978 and 1990. This article also estimates the risk of parental imprisonment for children whose parents did not finish high school, finished high school only, or attended college. Results show the following: (1) 1 in 40 white children born in 1978 and 1 in 25 white children born in 1990 had a parent imprisoned; (2) 1 in 7 black children born in 1978 and 1 in 4 black children born in 1990 had a parent imprisoned; (3) inequality in the risk of parental imprisonment between white children of college-educated parents and all other children is growing; and (4) by age 14, 50.5% of black children born in 1990 to high school dropouts had a father imprisoned. These estimates, robustness checks, and extensions to longitudinal data indicate that parental imprisonment has emerged as a novel—and distinctively American—childhood risk that is concentrated among black children and children of low-education parents.
Nature’s experiment? Handedness and early childhood development
Authors: Johnston David W. , Nicholls Michael E. R. , Shah Manisha , Shields Michael A. 
Published: May 2009

AbstractIn recent years, a large body of research has investigated the various factors affecting child development and the consequent impact of child development on future educational and labor market outcomes. In this article, we contribute to this literature by investigating the effect of handedness on child development. This is an important issue given that around 10% of the world’s population is left-handed and given recent research demonstrating that child development strongly affects adult outcomes. Using a large, nationally representative sample of young children, we find that the probability of a child being left-handed is not significantly related to child health at birth, family composition, parental employment, or household income. We also find robust evidence that left-handed (and mixed-handed) children perform significantly worse in nearly all measures of development than right-handed children, with the relative disadvantage being larger for boys than girls. Importantly, these differentials cannot be explained by different socioeconomic characteristics of the household, parental attitudes, or investments in learning resources.
Is the relationship between socioeconomic status and health stronger for older children in developing countries?
Authors: Cameron Lisa , Williams Jenny 
Published: May 2009

Abstract
Recent research on the relationship between child health and income in developed countries reveals a positive gradient that is more pronounced for older children, suggesting that the impact of income upon health accumulates. This article examines whether the same is true in a developing country. Using data from the Indonesian Family Life Survey on children aged 0 to 14 years, we find that although low income adversely affects health, its impact does not differ by age. This finding is robust to the use of both subjective and objective health measures, controlling for selective mortality, the use of alternative measures of households’ resources, and the inclusion of indicators of health at birth and parental health. One explanation for the constancy of the health-income relationship that we explore is the dominant role played by acute illness in determining the general health status of children in a developing-country context compared with the more central role played by chronic conditions in developed countries.
Proximate sources of population sex imbalance in india
Authors: Oster Emily 
Published: May 2009

Abstract
There is a population sex imbalance in India. Despite a consensus that this imbalance is due to excess female mortality, the specific source of this excess mortality remains poorly understood. I use microdata on child survival in India to analyze the proximate sources of the sex imbalance. I address two questions: when in life does the sex imbalance arise, and what health or nutritional investments are specifically responsible for its appearance? I present a new methodology that uses microdata on child survival. This methodology explicitly takes into account both the possibility of naturally occurring sex differences in survival and possible differences between investments in their importance for survival. Consistent with existing literature, I find significant excess female mortality in childhood, particularly between the ages of 1 and 5, and argue that the sex imbalance that exists by age 5 is large enough to explain virtually the entire imbalance in the population. Within this age group, sex differences in vaccinations explain between 20% and 30% of excess female mortality, malnutrition explains an additional 20%, and differences in treatment for illness play a smaller role. Together, these investments account for approximately 50% of the sex imbalance in mortality in India.
Motherhood, labor force behavior, and women’s careers: An empirical assessment of the wage penalty for motherhood in britain, germany, and the united states
Authors: Gangl Markus , Ziefle Andrea 
Published: May 2009

AbstractUsing harmonized longitudinal data from the British Household Panel Survey (BHPS), the German Socio-Economic Panel (GSOEP), and the National Longitudinal Survey of Youth (NLSY), we trace career prospects after motherhood for five cohorts of American, British, and West German women around the 1960s. We establish wage penalties for motherhood between 9% and 18% per child, with wage losses among American and British mothers being lower than those experienced by mothers in Germany. Labor market mechanisms generating the observed wage penalty for motherhood differ markedly across countries, however. For British and American women, work interruptions and subsequent mobility into mother-friendly jobs fully account for mothers’ wage losses. In contrast, respective penalties are considerably smaller in Germany, yet we observe a substantial residual wage penalty that is unaccounted for by mothers’ observable labor market behavior. We interpret this finding as indicating a comparatively more pronounced role for statistical discrimination against mothers in the German labor market.
Modeling transition rates using panel current-status data: How serious is the bias?
Authors: Wolf Douglas A. , Gill Thomas M. 
Published: May 2009

Abstract
Studies of disability dynamics and active life expectancy often rely on transition rates or probabilities that are estimated using panel survey data in which respondents report on current health or functional status. If respondents are contacted at intervals of one or two years, then relatively short periods of disability or recovery between surveys may be missed. Much published research that uses such data assumes that there are no unrecorded transitions, applying event-history techniques to estimate transition rates. In recent years, a different approach based on embedded Markov chains has received growing use. We assessed the performance of both approaches, using as a criterion their ability to reproduce the parameters of a “true” model based on panel data collected at one-month intervals. Neither of the widely used approaches performs particularly well, and neither is uniformly superior to the other.
Reconstructing childhood health histories
Authors: Smith James P. 
Published: May 2009

AbstractThis article provides evidence about the quality of retrospective childhood health histories given to respondents in the Health and Retirement Survey (HRS) and the Panel Study of Income Dynamics (PSID). Even though information on early life health events is critical, there is legitimate skepticism about the ability of older respondents to remember specific health problems that they had during childhood. The evidence presented in this article suggests that this view is too negative. Respondents appear to remember salient childhood events about themselves, such as the illnesses they had during childhood, quite well. Moreover, these physical and psychological childhood health events are important correlates of adult health during middle age.