Perioperative morbidity and renal function in young and elderly patients undergoing elective nephron‐sparing surgery or radical nephrectomy for renal tumours larger than 4 cm
Authors: Roos Frederik C. , Brenner Walburgis , Jäger Wolfgang , Albert Claudia , Müller Melanie , Thüroff Joachim W. , Hampel Christian 
Published: August 2010

Study Type – Therapy (case series) Level of Evidence 4 What’s known on the subject? and What does the study add? The incidence of renal tumours is rising constantly. Patients in the 6th or 7th decade of life are mainly affected. Nephron‐sparing surgery (NSS) has become the gold standard for the treatment of patients presenting with renal tumors ≤4 cm and is recommended for cT1b lesions in experienced centers.Little is known about the functional outcome of elderly patients presenting with renal tumours larger than 4 cm and being treated by NSS in comparison to radical nephrectomy (RN). Here we could show that NSS can be performed safely with considerable perioperative morbidity and a better functional outcome according to renal function without lacking oncological control.OBJECTIVETo analyse renal function, perioperative morbidity and overall survival (OS) in patients aged <55 years compared with patients aged >65 years treated by radical nephrectomy (RN) or elective nephron‐sparing surgery (NSS) for renal tumours >4 cm.PATIENTS AND METHODSFrom our database, we identified 829 patients with renal tumours >4 cm treated by either RN (n= 641) or NSS (n= 188) at our institution between 1981 and 2007. After excluding patients with imperative indication and metastases, we identified retrospectively 81 patients aged <55 years (young patients) and 85 patients aged >65 years (elderly patients) treated for renal tumours >4 cm. In all, 36 and 33 patients underwent NSS and 45 and 52 patients underwent RN in the young and elderly group, respectively. Preoperative and periodically postoperative serum creatinin values were used to estimate glomerular filtration rate (GFR). Chronic kidney disease (CKD) was defined as GFR <60 mL/min/1.73 m2. Clinical characteristics, complications and renal function were compared between age groups and surgical approaches, and OS was estimated using the Kaplan–Meier method.RESULTSThe median (range) tumour size in young patients was larger compared with that of elderly patients, i.e. 6 (4.2–14.0) cm vs 5 (4.2–16.0) cm, with P < 0.001 considered to be statistically significant. The complication rates did not differ between the age groups (P= 0.656) or between NSS and RN in young (P= 0.095) or elderly patients (P= 0.277). Chronic kidney disease after RN or NSS occurred in 31.1% and 15.5% for young patients, respectively and in 50.9% and 24.2% in elderly patients, respectively, until last available follow‐up which was obtained after a median (range) of 5.69 (0.1–19.2) years for young patients and 5.48 (0.8–18.1) years for elderly patients. Overall survival did not significantly differ between NSS vs RN in young (P= 0.655) and elderly patients (P= 0.058).CONCLUSIONOur findings suggest that performing NSS for tumours >4 cm when feasible in young and carefully selected elderly patients is more beneficial for maintaining long‐term renal function. Regardless of age, patients undergoing RN for renal tumours >4 cm developed more new onsets of CKD than patients treated by elective NSS. The complication rate did not differ between the age groups or between types of surgery.