bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effectiveness of Catch-Up Vaccination Interventions Versus Standard or Usual Care Procedures in Increasing Adherence to Recommended Vaccinations Among Different Age Groups: Systematic Review and Meta-Analysis of Randomized Controlled Trials and Before-After Studies
Authors: Fallucca Alessandra , Priano Walter , Carubia Alessandro , Ferro Patrizia , Pisciotta Vincenzo , Casuccio Alessandra , Restivo Vincenzo 
Published: April 2024

Background
To address the global challenge of vaccine hesitancy, the Strategic Advisory Group of Experts on Immunization strongly promotes vaccination reminder and recall interventions. Coupled with the new opportunities presented by scientific advancements, these measures are crucial for successfully immunizing target population groups.

Objective
This systematic review and meta-analysis aims to assess the effectiveness of various interventions in increasing vaccination coverage compared with standard or usual care. The review will cover all vaccinations recommended for different age groups.

Methods
In February 2022, 2 databases were consulted, retrieving 1850 studies. Following the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines, 79 manuscripts were included after the assessment phase. These comprised 46 trials/randomized controlled trials (RCTs) and 33 before-after studies. A meta-analysis using a random-effects model was performed with STATA software (version 14.1.2). The selected outcome was the risk ratio (RR) of vaccination coverage improvement effectiveness. Additionally, meta-regression analyses were conducted for the included manuscripts.

Results
The analyses showed an overall efficacy of RR 1.22 (95% CI 1.19-1.26) for RCTs and RR 1.70 (95% CI 1.54-1.87) for before-after studies when considering all interventions cumulatively. Subgroup analyses identified multicomponent interventions (RR 1.58, 95% CI 1.36-1.85) and recall clinical interventions (RR 1.24, 95% CI 1.17-1.32) as the most effective in increasing vaccination coverage for RCTs. By contrast, educational interventions (RR 2.13, 95% CI 1.60-2.83) and multicomponent interventions (RR 1.61, 95% CI 1.43-1.82) achieved the highest increases for before-after studies. Meta-regression analyses indicated that the middle-aged adult population was associated with a higher increase in vaccination coverage (RCT: coefficient 0.54, 95% CI 0.12-0.95; before-after: coefficient 1.27, 95% CI 0.70-1.84).

Conclusions
Community, family, and health care–based multidimensional interventions, as well as education-based catch-up strategies, effectively improve vaccination coverage. Therefore, their systematic implementation is highly relevant for targeting undervaccinated population groups. This approach aligns with national vaccination schedules and aims to eliminate or eradicate vaccine-preventable diseases.
Development of an Electronic Health Record Self-Referral Tool for Lung Cancer Screening: One-Group Posttest Study
Authors: Stang Garrett S , Tanner Nichole T , Hatch Ashley , Godbolt Jakarri , Toll Benjamin A , Rojewski Alana M 
Published: April 2024

Background
Approximately 14 million individuals in the United States are eligible for lung cancer screening (LCS), but only 5.8% completed screening in 2021. Given the low uptake despite the potential great health benefit of LCS, interventions aimed at increasing uptake are warranted. The use of a patient-facing electronic health record (EHR) patient portal direct messaging tool offers a new opportunity to both engage eligible patients in preventative screening and provide a unique referral pathway for tobacco treatment.

Objective
This study sought to develop and pilot an EHR patient-facing self-referral tool for an established LCS program in an academic medical center.

Methods
Guided by constructs of the Health Belief Model associated with LCS uptake (eg, knowledge and self-efficacy), formative development of an EHR-delivered engagement message, infographic, and self-referring survey was conducted. The survey submits eligible self-reported patient information to a scheduler for the LCS program. The materials were pretested using an interviewer-administered mixed methods survey captured through venue-day-time sampling in 5 network-affiliated pulmonology clinics. Materials were then integrated into the secure patient messaging feature in the EHR system. Next, a one-group posttest quality improvement pilot test was conducted.

Results
A total of 17 individuals presenting for lung screening shared-decision visits completed the pretest survey. More than half were newly referred for LCS (n=10, 60%), and the remaining were returning patients. When asked if they would use a self-referring tool through their EHR messaging portal, 94% (n=16) reported yes. In it, 15 participants provided oral feedback that led to refinement in the tool and infographic prior to pilot-testing. When the initial application of the tool was sent to a convenience sample of 150 random patients, 13% (n=20) opened the self-referring survey. Of the 20 who completed the pilot survey, 45% (n=9) were eligible for LCS based on self-reported smoking data. A total of 3 self-referring individuals scheduled an LCS.

Conclusions
Pretest and initial application data suggest this tool is a positive stimulus to trigger the decision-making process to engage in a self-referral process to LCS among eligible patients. This self-referral tool may increase the number of patients engaging in LCS and could also be used to aid in self-referral to other preventative health screenings. This tool has implications for clinical practice. Tobacco treatment clinical services or health care systems should consider using EHR messaging for LCS self-referral. This approach may be cost-effective to improve LCS engagement and uptake. Additional referral pathways could be built into this EHR tool to not only refer patients who currently smoke to LCS but also simultaneously trigger a referral to clinical tobacco treatment.
Unusual cause of bronchiolitis obliterans in an immunosuppressed patient
Authors: Neacșu Ana-Lavinia , Ruseva Inna Dencheva , Hallabrin Ionuț , Ene Cătălina , Leonte Diana , Toma Claudia 
Published: April 2024

Abstract
Bronchiolitis obliterans organizing pneumonia (BOOP) is a diffuse interstitial lung disease, currently classified as cryptogenic organizing pneumonia (COP) when idiopathic, respectively organizing pneumonia (OP) in case of a specified etiology.
We present the case of a 48-year-old patient, former smoker (20PY), diabetic, who accused moderate dyspnea, persistent febrile syndrome. The chest radiography showed multiple areas of condensation distributed bilaterally diffusely and the laboratory data revealed an important inflammatory syndrome. More than 100 colonies of Candida albicans were isolated from the sputum, therefore antifungal therapy was initiated. The computer tomography scan (CT scan) highlighted multiple micronodular and nodular lesions, some with tendency of excavation and hydroaeric level present and a polyseptate lesion in the right lower lobe; no proliferative elements were found during bronchoscopy and the bronchoalveolar lavage was non-specific; To obtain a final diagnosis, a CT-guided transthoracic needle biopsy was performed and the histological examination was compatible with organized pneumonia.
A framework for the identification of competencies required from Syrian pulmonologists during COVID-19 pandemic
Authors: Shaheen Mohsen , Al-Nerabieah Zuhair , Dashash Mayssoon 
Published: April 2024

Abstract

Objective
To identify essential competencies required for equipping pulmonologists to manage respiratory diseases such as the Covid-19 pandemic.

Methods
A descriptive and qualitative study was conducted. Focus group, which consisted of five Syrian members who were affiliated with the Syrian Association of Thoracic Medicine and Surgery were invited to formulate a preliminary list of competencies. Delphi technique with three cycles was also employed to evaluate the resulted list. The number of pulmonologists who accepted to take part was 67 out of 110. All competencies suggested by at least 80% of experts were included in the final list. Reliability was tested using Cronbach’s alpha, Descriptive statistics including Mean and standard deviation were performed.

Findings
Forty-five essential competencies were identified including ten competencies in cognitive domain, 11 skills, and 24 competencies related to attitude domain.

Conclusion
A list of 45 competencies has been identified. It is hoped that they will guide and enable pulmonologists to provide the best health care to patients with respiratory infections, especially during the COVID-19 pandemic. It will also guide decision makers to design training programs that can address these competencies.
Variation of Serum Vitamin B12 Level in the Blood from Patients of Different Age Among the Latvian Population
Authors: Gavars Didzis , Perminov Dmitry , Tauckels Eriks , Lindenberga Ilze , Miķelsone Agnese , Auce Agris 
Published: April 2024

Abstract
The reference intervals and median values of serum vitamin B12 level in blood from patients among the Latvian population were established for different age groups with a two-year step using data for a large number of patients, accumulated in E. Gulbis Laboratory in Latvia. The data represents the general population of Latvia. An indirect in silico method, developed in E. Gulbis laboratory for determination of serum vitamin B12 blood level reference intervals, was used. Strong elevation of serum vitamin B12 blood level was observed in children who were between 2 and 10 years old. The paper discusses the serum vitamin B12 values for children and a different serum vitamin B12 reference interval for young children is suggested.
How to make your sinus surgery more comfortable: our point of view
Authors: Eloy Philippe , Musat Gabriela 
Published: April 2024

Abstract

BACKGROUND. Endoscopic sinus surgery (ESS) has revolutionized the treatment of nasal and paranasal sinus conditions, offering minimally invasive techniques with improved patient outcomes. However, ESS can be challenging, lengthy, and physically demanding. This article presents a comprehensive overview of factors to consider before and during ESS to enhance surgical ease and patient comfort.

MATERIAL AND METHODS. The paper is a literature review sustaining a point of view on the factors influencing the outcome of endoscopic sinus surgery.

RESULTS. Preoperative considerations encompass a thorough assessment of surgical indications, weighing against medical alternatives as per guidelines. Attention to patient comorbidities, medication management and infection control are paramount. Intraoperatively, collaboration with anesthesiologists is crucial for optimizing patient stability and minimizing complications. Ergonomic considerations, patient positioning and surgical environment optimization contribute to surgeon comfort and procedural efficiency. The surgical procedure entails meticulous preparation of the nasal cavity, preservation of anatomical structures, and adherence to standardized techniques. The sphenoethmoidectomy is described as a sequential five-door procedure, emphasizing anatomical landmarks and meticulous dissection techniques. Hemostasis and the judicious use of powered shavers play pivotal roles in minimizing bleeding and optimizing tissue removal. Navigation systems offer additional support, particularly in complex cases or revision surgeries.

CONCLUSION. ESS requires meticulous planning, technical proficiency, and interdisciplinary collaboration to optimize outcomes. Anticipation and adherence to standardized protocols are paramount in navigating the challenges of ESS, ultimately enhancing surgical ease and patient comfort.
Technological Innovation and the Use of Nanotechnology in Companies
Authors: Lemos Lelles de Paula 
Published: April 2024

Objective: This article aims to highlight the types, benefits, and challenges of technological innovation in companies, the use of nanotechnology, its benefits, applicability, and challenges.

Theoretical Framework: Firstly, the benefits and challenges of technological innovation were listed, the types of innovation that can be used and then, within this process, the focus was on nanotechnology, presenting its methods and applications.

Method: The methodology adopted comprises the foundation through bibliographic texts and a brief analysis of a company to confirm the benefits listed in the theory. Therefore, this article uses exploratory research as a methodology.

Results and Discussion: Technological innovation uses technologies, both consolidated and disruptive. Therefore, it brings benefits such as competitive advantage, differentiation, and market gain. Nanotechnology is a technological innovation, so its benefits are the same as those evident in this type of innovation. As challenges, we understand high investments, continuous innovation, and impeding regulations.

Research Implications: When analyzing Nanox, a nanotechnology company, it became clear that this technology can be applied to packaging, construction, clothing, water treatment and many others. In theory, it was demonstrated that in technological innovation, nanotechnology enables the manipulation of nano components in the creation of disruptive products, which can be applied to various products and materials, which has been confirmed in practice.

Originality/Value: This study contributes to the literature by providing evidence of the characteristics and benefits of the main technologies that make up technological innovation. The relevance and value of this research are highlighted by providing a better understanding of current technologies and innovations.
Exploring a complex case of catatonia treatment using diazepam in a middle-aged female: a multidisciplinary exploration of a unique case - a case report
Authors: Ababtain Hind , Alessa Abdullah , Aseeri Ahmed 
Published: April 2024

Background:
This case report delves into the intricate interplay between medical and psychiatric domains through the detailed analysis of a 41-year-old female patient presenting with a myriad of symptoms, including decreased level of consciousness, urinary tract infection, and subsequent catatonia secondary to depression with psychotic features.

Case Presentation:
The collaborative involvement of Internal Medicine, Neurology, Infectious Disease, and Adult Mental Health specialists underscores the necessity of a multidisciplinary approach. The temporal evolution of the patient’s condition, coupled with the sequential adjustments in treatment strategies, provides insights into the nuanced manifestations of overlapping medical and psychiatric conditions.

Conclusion:
This report aims to highlight the intricate diagnostic process, treatment challenges, and the collaborative efforts required for the successful management of this rare and multifaceted case.
Compare Some Shrinkage Bayesian Estimation Method forGumbel-Max Distribution with Simulation
Authors: Shallan Rehab noori 
Published: April 2024

The Gumbel max distribution is one of the most important statistical distributions because it has many applications, especially in the field of water research and the prediction of earthquakes and volcanoes. This work includes a comparison of several Shrinkage Bayesian methods, namely the Shrinkage Bayesian Square Loss Function, Shrinkage Bayesian Lenix Function, and Shrinkage Bayesian Unix Function to estimate the distribution parameter. The research also includes several simulated experiments according to the sample size change and the real value of the distribution parameter. The number of experiments is 15 simulated experiments based on the difference sample size and true distribution parameter values. The results of the simulation experiments are compared depending on each of the absolute least difference criteria ( and the mean squared error (). The comparison results show that the estimation method is affected by the sample size, and the real value of the distribution parameter. The best estimation method is the Shrinkage Bayesian Lenix Function. The Bayesian methods can be applied to other statistical distributions such that the Lindley Weibull distribution and logistics distribution.
Perspectives on African Indigenous Religion and the Natural Environment: Beings, Interconnectedness, Communities and Knowledge Systems
Authors: Nche George C. , Michael Benson Ogar 
Published: April 2024

This article explored the intricate relationship between African Indigenous Religion (AIR) and the natural environment. It uncovered diverse perspectives on how African communities historically engage with and conserve their natural surroundings and underscored the contemporary relevance of these insights in addressing global environmental challenges. The article covered a wide range of online and offline materials, including books, book chapters, and journal articles, offering a comprehensive understanding of the connections between indigenous belief systems and environmental conservation in Africa. By analysing key recurring themes and concepts within the literature, including African ontology, belief in God, ancestral roles, deities, community values, moral status, and Indigenous Knowledge Systems (IKS), the article synthesised insights from previous research and identified important areas for future research.
THE SIGNIFICANCE OF ACMEHERMENEUTIC APPROACH IN PREPARING STUDENTS OF FACULTIES OF ARTS FOR PERFORMING ACTIVITIES
Authors: Mymryk Mykhailo 
Published: April 2024

The article reveals the significance of the acmehermeneutic approach in the preparation of art faculty students for performance. From the standpoint of the classics of philosophical hermeneutics and the works of modern scientists, the essence of the main concepts of the article, namely: "hermeneutics", "interpretation", "acmeology", was considered. The author's understanding of the acmehermeneutic approach is presented, which is defined as a new direction of performing activities of students of the faculties of arts, which provides a comprehensive coverage of the content of the images of a musical work, which is performed in unity with its form. Proposing the application of an acmehermeneutic approach in the process of performing activities of students of art faculties, we consider it expedient to: deep understanding by students of the figurative essence of a musical work, the formation of students' ability to reveal, understanding of the means of expression that the composer chose to express his feelings, enabling the activation of students' emotional response to a musical work through their involvement in the intellectual understanding of the origins of beauty. Key words: acmehermeneutic approach, students of art faculties, performing activity, interpretation, works of art, intellectual understanding.
Dry Heat Sterilization of a Pelleted, Natural Ingredient Rodent Diet
Authors: Kurtz David M , Whiteside Tanya E , Caviness Gordan , Lih Fred B 
Published: April 2024

AbstractSterilization of rodent feed is recommended to eliminate potential murine pathogens and minimize microbial variability between batches. Most research institutions sterilize feed using steam/pressure (autoclave) or irradiation. Both methods have advantages and disadvantages that contribute to their suitability, including cost, maintenance, availability, and alterations to the exposed product. Dry heat sterilization, which has been in use for over 75 y, uses higher temperatures and longer sterilization times than steam autoclave and is most often used for delicate instruments or products that would be damaged by water such as powders or oil-based liquids. Dry heat sterilization in vivaria has been limited to date but is gaining popularity due to lower initial purchase and ongoing operational costs as compared with steam autoclaves. Little published information exists on the effects of dry heat sterilization on animal feed. We evaluated the sterility and chemical alterations of a natural ingredient, pelleted, rodent diet (NIH-31) after exposure to dry heat. Feed sterility was achieved using a dry heat exposure temperature of 160 °C (320 °F) for 4 h. This exposure resulted in a significant loss of heat-labile vitamins and significantly more acrylamide production as compared with the nonsterile, irradiated, and autoclaved feed.
Non-Fungible Tokens for Organoids: Decentralized Biobanking to Empower Patients in Biospecimen Research
Authors: Sanchez William , Linder Larue , Miller, Robert , Hood Amelia , Gross Marielle 
Published: April 2024

Introduction: Scientists use donated biospecimens to create organoids, miniature copies of patient tumors1 that are revolutionizing precision medicine2 and drug discovery. However, current biobanking platforms remove patient names to protect privacy, precluding communication of health information and research findings between bench and bedside3. We leverage tokenization, transparency, and privacy-preservation of blockchain technology to advance a decentralized biobanking prototype empowering patient engagement in organoid research.
Methods: We design and develop a proof-of-concept NFT framework4 for a simulated human cancer model research network. Our implementation deployed multiple smart contracts on Ethereum test networks which minted NFTs representing each stakeholder, biospecimen, and organoid, a NodeJS server using a Metamask wallet to interact with blockchain through an Infura hosted node, and a Flutter mobile application connected to a Firebase Database to demonstrate biobanking activities.
Results: Our prototype demonstrated the viability of NFTs representing patients, physicians, scientists, and organoids while preserving privacy, and displayed how decentralized biobanking could be integrated into existing biobanking platforms5. The application featured key activities for patients, including biospecimen tracking, the ability to view organoids, learn about ongoing studies, and peer-to-peer communications with scientists.
Discussion: Our prototype demonstrates proof-of-concept for a web3 platform that engages patients, physicians and scientists in an privacy-preserving organoid community. Further research is needed to advance decentralized biobanking features, encapsulating complex organoid research activities, and to assess feasibility and acceptability of implementing our approach.
Gathering voices and experiences of Australian military families: Developing family support resources
Authors: Rogers Marg , Johnson Amy , Coffey Yumiko 
Published: April 2024

LAY SUMMARY Research has often overlooked the voices of children from Australian Defence Force families. Past research on how young children experience military family life relied heavily on parents’ perspectives alone, leaving children’s voices unheard. In this study, 19 young children were recognized as competent communicators and experts in their own lives while also valuing the insights of their parents and early childhood educators. Children’s unique perspectives, knowledge, and experiences were collected through shared stories, chats, observation, photographs, reflection, and the creative arts. The study found children of deployed parents experienced physical, social, emotional, and cognitive responses and difficulty with frequent relocations and family transitions, often related to parental deployment and training episodes. Risk and protective factors, and a shortage of resources that cater to their age and cultural backgrounds to support children in making sense of their experiences, were discovered. The authors co-created free online research-based resources to address this gap and build children’s strengths.