bluuebunny/crossref_metadata_2025_split huggingface dataset:
Quand l’argument environnemental fait capoter le rêve olympique. L’exemple de la candidature de Lausanne aux Jeux olympiques d’hiver de 1994
Authors: Vonnard Philippe 
Published: June 2024

Juin 1988, la population de la ville de Lausanne rejette à 62 % une candidature pour les Jeux olympiques d’hiver (JOH) de 1994. Ce résultat constitue une douche froide pour les promoteurs du projet qui insistent, depuis son lancement, sur le fait que la population est enthousiaste vis-à-vis de celui-ci. Tenant compte que le comité référendaire est composé très largement de membres de partis ou d’associations écologistes, cet article a pour objectif d’aborder l’argument environnemental dans le cadre de cette candidature. Basée sur un dépouillement d’archives publiques et privées largement inédites, documentation qui a été enrichie par une revue extensive de la presse locale et de document audiovisuels de l’époque, cette recherche étudie les arguments et le profil des opposants et opposantes, et elle analyse la réception de ces critiques par les organisateurs, c’est-à-dire la manière dont ces derniers en tiennent compte ou au contraire les minimisent, voire les rejettent. L’étude du cas lausannois permet plus largement de questionner les rapports entre les Jeux olympiques et la thématique environnementale au mitan des années 1980.
De la saisie du Chrestien au Gaoulé : colonialité, transimpérialité et commerce étranger à la Martinique au début du XVIII e siècle
Authors: Schnakenbourg Éric 
Published: June 2024

En janvier 1717, La Varenne et Ricouart arrivaient à la Martinique en qualité d’administrateurs de la colonie, mais en étaient chassés par un soulèvement des colons quatre mois plus tard. Ce bref épisode permet de poser un regard sur les enjeux du commerce étranger dans les petites Antilles au début du xviii e siècle. Le postulat initial est de ne pas considérer uniquement le commerce étranger comme de la contrebande, mais comme une forme d’organisation complémentaire des échanges qui participait, malgré son illégalité, à la pérennisation du modèle colonial et au développement de l’économie de plantation esclavagiste.
Grands Challenges et politiques publiques d’innovation : un état des lieux
Authors: Liotard Isabelle , Revest Valérie 
Published: June 2024

La recherche en sciences sociales met en lumière l’importance croissante des grands défis sociétaux, tels que le réchauffement climatique ou le vieillissement de la population. Ces défis complexes, qui évoluent dans le temps, nécessitent une approche multidisciplinaire, intégrant des aspects technologiques et sociaux. Les politiques publiques traditionnelles sont souvent inadaptées à ces défis pernicieux, nécessitant une transformation vers des politiques d’innovation orientées vers des missions, où les objectifs sociaux et environnementaux guident les efforts d’innovation. Cette approche implique une collaboration entre acteurs publics, privés et non lucratifs, ainsi qu’une participation inclusive de toutes les parties prenantes. L’innovation, autrefois perçue comme un moteur de progrès, est aujourd’hui source de certaines critiques. Les politiques d’innovation doivent donc évoluer vers une approche plus réfléchie, inclusive et flexible, centrée sur la résolution collective de problèmes pernicieux, avec une attention particulière portée à l’engagement des parties prenantes et à la responsabilité sociale de l’innovation. Codes JEL : O30, O35, O38
Jean Laplanche, un héritage fécond
Authors: Lecoq Arlette 
Published: June 2024

Parmi les héritiers de la théorie de Jean Laplanche, l’auteure a sélectionné des moments théoriques chez Dominique Scarfone et chez Christophe Dejours. Du premier, il sera question de l’actuel impassé qu’il importe de repérer pour distinguer dans l’écoute du patient ce qui est présenté de ce qui est représenté. Quant à la pulsion sexuelle de pouvoir proche de la pulsion d’emprise, elle permet de dissocier les déviances consensuelles des déviances non consensuelles et éclairent d’un jour nouveau la violence et la sexualité d’aujourd’hui. C’est la troisième topique et l’inconscient amential développés par Christophe Dejours qui seront ensuite présentés ; ils permettent de généraliser les notions de clivage, de vulnérabilité somatique et éclairent les risques de décompensations majeures.
Souffrance au travail : sur quels concepts analytiques s’appuyer pour l’écouter ?
Authors: Ego Eveline , Castiau Géraldine 
Published: June 2024

La clinique quotidienne amène les praticiens à rencontrer de plus en plus de patients exprimant une souffrance au travail, avec leurs lots de décompensations psychiques voire physiques. Notre écoute et notre positionnement analytiques traditionnels ne suffisent souvent plus à comprendre, explorer et analyser cette souffrance. Jean Laplanche, avec sa « centralité du sexuel » et les « messages intromis », puis Christophe Dejours, collègue et condisciple de Jean Laplanche, avec son concept de « double centralité du sexuel » et sa théorie de la « Psychodynamique du Travail », nous offrent des concepts et une grille de lecture psychanalytique plus aptes à saisir les enjeux de cette souffrance.
Accuracy of 12 Intraocular Lens Power Formulas After Corneal Myopic Refractive Surgery
Authors: Rong Xin , Liu Jiewei , Jiang Lin , Wang Xiaogang , Feng Tianfeng , Lu Zhenyang , Fan Zeqi , Yan Hua 
Published: June 2024

Purpose:
To assess the predictive accuracy of new-generation online intraocular lens (IOL) power formulas in eyes with previous myopic laser refractive surgery (LRS) and to evaluate the influence of corneal asphericity on the predictive accuracy.

Methods:
The authors retrospectively evaluated 52 patients (78 eyes) with a history of laser in situ keratomileusis (LASIK) or photorefractive keratectomy (PRK) who subsequently underwent cataract surgery. Refractive prediction errors were calculated for 12 no-history new online formulas: 8 formulas with post-LRS versions (Barrett True-K, EVO 2.0, Hoffer QST, and Pearl DGS) using keratometry and posterior/total keratometry measured by IOLMaster 700 and 4 formulas without post-LRS versions (Cooke K6 and Kane) using keratometry and total keratometry. The refractive prediction error, mean absolute error (MAE), and percentages of eyes with prediction errors of ±0.25, ±0.50, ±0.75, ±1.00, and ±1.50 diopters (D) were compared.

Results:

The MAEs of the 12 formulas were significantly different (F = 83.66,
P
< .001). The MAEs ranged from 0.62 to 0.94 D and from 1.07 to 1.84 D in the formulas with and without post-LRS versions, respectively. The EVO formula produced the lowest MAE (0.60) and MedAE (0.47), followed by the Barrett True-K (0.69 and 0.50, respectively). Each percentage of eyes with refractive prediction error was also significantly different among the 12 formulas (
P
< .001).

Conclusions:
The EVO and Barrett True-K formulas demonstrate comparable performance to the other existing formulas in eyes with a history of myopic LASIK/PRK. Surgeons should use these formulas with post-LRS versions and input keratometric values whenever possible.

[
J Refract Surg
. 2024;40(6):e354–e361.]
Photorefractive Keratectomy in Experienced U.S. Naval Aviators: A Prospective Evaluation
Authors: Tanzer David J. , Brown Mitchell C. , Schallhorn Steven C. 
Published: June 2024

Purpose:
To report on the prospective evaluation of photorefractive keratectomy (PRK) in experienced ametropic naval aviators that led to the approval of refractive surgery for military pilots.

Methods:
This was the first study evaluating refractive surgery in naval aviators. Return to flight status after PRK and clinical outcomes and subjective and objective flight performance were evaluated.

Results:
A total of 785 U.S. naval aviators were enrolled in the study. Average preoperative refraction was −2.92 ± 1.73 diopters (D) (range: +5.25 to −9.13 D). By 6 months, 85.9% of eyes were within ±0.50 D and 96.4% were within ±1.00 D of emmetropia. 94.4% of eyes achieved 20/20 or better, 74.3% had 20/16 or better, and 45.2% had 20/12.5 or better uncorrected distance visual acuity (UDVA) at 6 months. A total of 78.5% of aviators met return-to-flight criteria by 4 weeks, 83.3% by 8 weeks, and 90.8% by 12 weeks following PRK. All aviators eventually returned to full flight status. Cumulative flight experience included logging more than 48,000 flight hours and 19,500 landings in the 6 months following PRK. Psychometric questionnaire results showed that 78% reported improved ability to detect other aircraft and 92% reported improved ability to land on an aircraft carrier (82% significantly improved) compared to wearing corrective lenses. No one felt their vision was worse in these dynamic environments. All aviators indicated they would undergo the procedure again and would recommend it to a fellow aviator.

Conclusions:
This prospective study in U.S. naval aviators determined PRK to be safe and effective in a unique patient population operating in a visually demanding and hazardous environment. The program continues to be enthusiastically supported by aviators and PRK is now allowed in all branches of the military and for National Aeronautics and Space Administration astronauts.

[
J Refract Surg
. 2024;40(6):e371–e380.]
Effect of Corneal Allogenic Intrastromal Ring Segment (CAIRS) Implantation Surgery in Patients With Keratoconus According to Prior Corneal Cross-linking Status
Authors: Yucekul Burcu , Tanriverdi Cafer , Taneri Suphi , Keskin Perk Fatma Feyza Nur , Karaca Yigit , Kilic Aylin 
Published: June 2024

Purpose:
To compare the effects of corneal allogenic intrastromal ring segment (CAIRS) implantation on topographical measurements and visual outcomes of patients with keratoconus with and without corneal cross-linking (CXL) prior to the time of implantation.

Methods:
Sixty-seven eyes with corneal allograft intrastromal ring segment implantation (KeraNatural; Lions VisionGift) due to advanced keratoconus were included in the study. Thirty-seven eyes had no CXL and 30 eyes had had CXL before being referred to the authors. The changes in spherical equivalent (SE), uncorrected distance visual acuity (UDVA), corrected distance visual acuity (CDVA), steep keratometry (K1), flat keratometry (K2), mean keratometry (Kmean), maximum keratometry (Kmax), and thinnest pachymetry were retrospectively analyzed 6 months after the implantation.

Results:

The median age was 29 years in the CXL group and 24.0 years in the non-CXL group (
P
> .05), respectively. All topographical and visual parameters before implantation were similar in both groups (
P
> .05 for all parameters). At 6 months, CDVA, K1, and Kmean showed higher improvement in the non-CXL group than the CXL group (
P
= .030, .018, and .039, respectively).

Conclusions:
CAIRS surgery has a flattening effect on both the corneas with and without CXL. The cornea with prior CXL treatment had less flattening effect due to the stiffening effect of prior CXL.

[
J Refract Surg
. 2024;40(6):e392–e397.]
Le foyer obscur de l’évidence
Authors: Mehl Édouard 
Published: June 2024

L’œuvre de Jean-Luc Nancy se tisse autour du concept d’existence, modifié ou plutôt explicité comme co-existence. Nancy effectue sur l’existence l’opération que Heidegger menait à propos de l’être-au-monde ; en effet, comme Heidegger pouvait dire qu’il n’y a pas d’abord un sujet, puis un monde, puis la question de savoir comment le premier accède au second, Nancy affirme, à propos du Mitsein, de l’être-avec, de la socialité au sens le plus pur et le plus éminent, qu’il n’y a pas d’abord un sujet, un moi, puis un autre moi, puis la question de savoir comment l’un accède à l’autre, et comment ils peuvent communiquer ensemble. Il faut partir de « nous », et du sens que « nous » sommes, donc d’une « analytique coexistentiale ».
Assessment of thyroid function in children and adolescents with chronic liver diseases
Authors: Mahfouz Aml A. , Hassan Azza , Raafat Shaymaa 
Published: June 2024

IntroductionThe majority of hepatic patients are clinically euthyroid. However, liver disorders may alter thyroid hormone metabolism, including substantial abnormalities of either euthyroid sick syndrome (ESS), autoimmune thyroid disorders, or subclinical hypothyroidism (SH). But there are few studies conducted on children with chronic liver diseases (CLD) to assess thyroid functions.AimThe study aimed to evaluate thyroid profiles in patients with CLD.Patients and methodsAn observational, cross-sectional study including patients with CLD attending Hepatology Clinic at Alexandria University Children’s Hospital from June 2021 to June 2022. One hundred and two children were included and a history taking and clinical examination were performed. Assessment of severity using a modified Child–Pugh score was done. Laboratory investigations in the form of liver, lipid, and thyroid profiles were done.ResultsOne hundred and two children with CLD were included in this study, 50 (49.0%) females and 52 (51.0%) males. The most common diagnosis in the studied cases was autoimmune hepatitis (24.5%), followed by glycogen storage disease. Out of 14 (13.7%) aberrant outcomes of thyroid function, seven (6.9%) patients had ESS, and seven (6.9%) individuals had SH. By univariate analysis, alkaline phosphatase and serum albumin level were significant risk factors for SH. Furthermore, melena and hepatic encephalopathy were significant risk factors for ESS.ConclusionThyroid dysfunction might occur in CLDs either in the form of SH or ESS. The prevalence of thyroid disease in children with CLD exceeded 10%, which signifies the importance of screening for thyroid dysfunctions in this cohort.
Risk factors, antimicrobial susceptibility, and outcome of methicillin-resistant Staphylococcus aureus bacteremia in critically ill children with sepsis in a tertiary hospital in Egypt
Authors: El-Halaby Hanan , Elbayoumi Mohamed A. , Elhusseiny Ahmed , El-Shahawy Heba A. , Noaman Ahmed 
Published: June 2024

Background

Staphylococcus aureus bacteremia (SAB) and methicillin-resistant Staphylococcus aureus (MRSA) infection are associated with unfavorable outcomes.

Aim
To reveal the risk factors, sensitivity to antibiotics, and outcome of MRSA bacteremia in infants and children with sepsis.

Settings and design
A prospective observational cross-sectional study was performed in Mansoura University Children’s Hospital from March 2023 to January 2024.

Patients and methods
The study involved infants and children diagnosed with sepsis and confirmed SAB on blood culture. Demographic data and blood culture with antibiotics sensitivity were recorded. Risk factors for MRSA bacteremia, antibiotic susceptibility, and mortality are the study outcomes.

Statistical analysis used
Multivariate analysis was done to assess the predictors of MRSA infection.

Results
A total of 319 patients were admitted with sepsis. SAB was isolated from 133 patients, 99 (74.4%) with methicillin-sensitive Staphylococcus aureus and 34 (25.6%) with MRSA. Risk factors for the development of MRSA infection are the presence of hospital-acquired infection (adjusted odds ratio=6.95), prolonged mechanical ventilation, presence of shock, and decreased body weight. Mortality was higher in the MRSA group (20.6 vs. 6.1%, P=0.014) with prolonged median duration of pediatric intensive care unit admission (19.5 vs. 14 days; P=0.040). Linezolid and teicoplanin were the most efficient antibiotics used in MRSA with 100% sensitivity in-vitro cultures, whereas resistance to erythromycin (90.9%) was documented.

Conclusion
MRSA poses a significant threat in pediatric sepsis. The presence of hospital-acquired infection and prolonged mechanical ventilation are the chief predictors of MRSA infection. Linezolid and teicoplanin are the most sensitive antibiotics used in MRSA management.
Evaluation of Serum Vitamin D Level in Full-Term Neonates with Hypoxic–Ischemic Encephalopathy
Authors: Elgayar Ahmed A. , El-Sharkawy Hamed M. , El-Bindary Amal S. , Nassar Mohamed A. , Hamza Mohamed B. 
Published: June 2024

Background
Vitamin D has a role in minimizing the extent of neuronal cell injury and death in neonatal hypoxic–ischemic encephalopathy (HIE).

Aim
To assess the serum level of vitamin D in full-term babies with HIE.

Patients and methods
This case–control study was conducted on 40 full-term neonates. Cases were grouped into two groups: group A: 30 full-term neonates diagnosed as HIE; clinical diagnosis was based on Sarnat staging. Group B: 10 healthy full-term neonates. Patients in group A were further subdivided into three equal groups: group A1: grade I HIE, group A2: grade II HIE, and group A3: grade III HIE.

Results
The following investigations were done for groups A and B: Apgar score after 1 and 5 min, convulsions, metabolic acidosis need for respiratory support, blood urea, serum creatinine, C-reactive protein level, serum calcium levels, and 25(OH) vitamin D measurements at 12 and 72 h postnatal. Apgar score, pH, total and ionized calcium, and 25(OH)-D were significantly reduced in HIE (specially grade III), while blood urea, serum creatinine, and C-reactive protein were significantly higher in HIE neonates (grade III).

Conclusion
We could assume that the more severe the grade of HIE, the worse are the laboratory findings.
Transferrin receptor 1 rs3817672 variant genotyping in Egyptian children diagnosed with iron-deficiency anemia: a case–control study
Authors: El-Gendy Wessam , Hassab Hoda , Ismail Hamis , Tahoun Mona 
Published: June 2024

Background
Cell surface transferrin receptor 1 (TFR1) is a gatekeeper controling cellular iron uptake. The association of iron-deficiency anemia (IDA) in humans with TFR1 variants was not extensively studied. Among these variants is TFR1 rs3817672, an exonic missense variation that may affect the TFR1 protein structure. This is the first study in Egypt and the second worldwide that genotype TFR1 rs3817672 variant in IDA pediatric patients.

Aim
The aim of the current study was to investigate the association between TFR1 rs3817672 variant with susceptibility risk for IDA.

Patients and methods
The study was conducted on 50 IDA Egyptian pediatric patients and 50 healthy controls. Complete blood count, iron profile, and TFR1 rs3817672 variant genotyping were performed for all participants.

Results
TT genotype was associated with a high risk of IDA among cases compared to controls in the recessive model (odds ratio 24, 95% confidence interval 5.253–109.650, P≤0.001) with the predominance of T allele (odds ratio 7.3187, 95% confidence interval 3.919–13.669, P≤0.001). TT genotype was associated with a significant decrease in serum iron (P=0.001 and 0.003) and transferrin saturation (P=0.003 and 0.005) compared to CT genotype and CC+CT genotypes in the recessive model, respectively. In IDA patients, serum iron had a significant positive correlation with transferrin saturation (r=0.984, P≤0.001) and a significant negative correlation with total iron-binding capacity (r=−0.555, P≤0.001).

Conclusion
TT genotype was the predominant genotype among Egyptian pediatric IDA patients. TFR1 rs3817672 genotyping might be used as a potential screening test for IDA risk susceptibility in pediatrics.
Prevalence and outcome of inborn errors of metabolism among high-risk neonates: an Egyptian single-center study
Authors: Mokhtar Wesam A. , Hesham Mervat A. , Abdo Shams S. 
Published: June 2024

Background
Inborn errors of metabolism (IEM) are genetic disorders caused by incompetence in enzymatic reactions of intermediary metabolism due to an insufficient amount or unstable form of the involved enzyme.

Aim
To assess the prevalence and outcome of IEM among high-risk neonates for early diagnosis and detection of treatable causes to minimize morbidity and mortality rate in neonates.

Methods
This cross-sectional study was carried out on 684 neonates at the Neonatal Intensive Care Unit in the Pediatrics Department at Zagazig University Children’s Hospital from February 2020 to February 2023. Extended metabolic screen (EMS) was done for full-term neonates and preterm of more than 32 weeks of gestation. Further investigations such as plasma ammonia, plasma lactate, urine organic acid analysis, blood gas, serum anion gap, and the blood glucose level were also measured.

Results
The prevalence of IEM was 4.4%. The most common presentations among the cases of IEM were not doing well, respiratory distress, encephalopathy, and convulsion. As regards provisional diagnosis, 11 cases were diagnosed as maple syrup urine disease, 5 cases with glycine encephalopathy, 5 cases with medium-chain acyl CoA dehydrogenase deficiency,4 cases with methylmalonic acidemia, 2 cases with isovaleric acidemia, 2 cases with citrullinemia type 1, and one case with propionic academia; 12 (40%) of IEM cases died.

Conclusion
IEM disorders are not rare diseases in high-risk neonates with attention to consanguinity, which is a common tradition in our country. The delay in diagnosis of IEM leads to high morbidity and mortality.
Prevalence and impact of interleukin-6 and interleukin-10 polymorphisms in Egyptian children with immune thrombocytopenic purpura
Authors: Ramadan Hala , Mahmoud Mona M. , Elhawary Eslam E. , Hablas Nahed M. 
Published: June 2024

Background
Recent findings demonstrate that complex immune system dysregulation plays a role in the etiology of immune thrombocytopenic purpura (ITP) Aim

Aim
The current study aimed to assess the prevalence and impact of interleukin-6 (IL-6) and IL-10 polymorphisms and levels in Egyptian children with ITP.

Patients and methods
In this case–control study, 25 Egyptian children with newly diagnosed ITP took apart. Their mean age was 9±2.56. They were treated at Tanta University Hospital’s Hematology Unit, Pediatric Department. Furthermore, 25 healthy age-matched and sex-matched children were included as controls. Both groups were subjected to complete blood count, PCR for IL-6 572G>c=rs1800796 and IL-10 627A>C=rs1800872, and enzyme-linked immunosorbent assay measurement of serum levels of IL-6 and IL-10.

Results
Eight percent of our patients tested positive for IL-6 (572) polymorphism (G/C), 4% tested positive in controls. Meanwhile 4% of cases tested positive for IL-10 (627) polymorphism (A/C), indicating that there was no statistically significant difference between groups. Patients’ levels of IL-6 and IL-10 were considerably higher (P<0.0001). Moreover, there was a statistically significant difference between the acute and chronic cases, with the former having a higher level. The levels of IL-6 and IL-10 and the platelet count showed a statistically significant strong negative correlation.

Conclusion
IL-10 polymorphisms are thought to play a part in the pathogenesis of childhood ITP. Moreover, IL-6, seems to predict susceptibility to primary ITP in Egyptian children making both promising biomarkers of clinical progression. However, a sizable prospective study is required to find out how cytokine gene polymorphisms affect childhood ITP.