bluuebunny/crossref_metadata_2025_split huggingface dataset:
Associations between fasting glucose rate-of-change and the missense variant, rs373863828, in an adult Samoan cohort
Authors: Rivara Anna C. , Russell Emily M. , Carlson Jenna C. , Pomer Alysa , Naseri Take , Reupena Muagututia Seifuiva , Manna Samantha L. , Viali Satupaitea , Minster Ryan L. , Weeks Daniel E. , DeLany James P. , Kershaw Erin E. , McGarvey Stephen T. , Hawley Nicola L. 
Published: June 2024

Background
The A allele of rs373863828 in CREB3 regulatory factor is associated with high Body Mass Index, but lower odds of type 2 diabetes. These associations have been replicated elsewhere, but to date all studies have been cross-sectional. Our aims were (1) to describe the development of type 2 diabetes and change in fasting glucose between 2010 and 2018 among a longitudinal cohort of adult Samoans without type 2 diabetes or who were not using diabetes medications at baseline, and (2) to examine associations between fasting glucose rate-of-change (mmol/L per year) and the A allele of rs373863828.

Methods
We describe and test differences in fasting glucose, the development of type 2 diabetes, body mass index, age, smoking status, physical activity, urbanicity of residence, and household asset scores between 2010 and 2018 among a cohort of n = 401 adult Samoans, selected to have a ~2:2:1 ratio of GG:AG: AA rs373863828 genotypes. Multivariate linear regression was used to test whether fasting glucose rate-of-change was associated with rs373863828 genotype, and other baseline variables.

Results
By 2018, fasting glucose and BMI significantly increased among all genotype groups, and a substantial portion of the sample developed type 2 diabetes mellitus. The A allele was associated with a lower fasting glucose rate-of-change (β = −0.05 mmol/L/year per allele, p = 0.058 among women; β = −0.004 mmol/L/year per allele, p = 0.863 among men), after accounting for baseline variables. Mean fasting glucose and mean BMI increased over an eight-year period and a substantial number of individuals developed type 2 diabetes by 2018. However, fasting glucose rate-of-change, and type 2 diabetes development was lower among females with AG and AA genotypes.

Conclusions
Further research is needed to understand the effect of the A allele on fasting glucose and type 2 diabetes development. Based on our observations that other risk factors increased over time, we advocate for the continued promotion for diabetes prevention and treatment programming, and the reduction of modifiable risk factors, in this setting.
Lung ultrasound is associated with distinct clinical phenotypes in COVID-19 ARDS: A retrospective observational study
Authors: Dayan Roy Rafael , Blau Maayan , Taylor Jonathan , Hasidim Ariel , Galante Ori , Almog Yaniv , Gat Tomer , Shavialiova Darya , Miller Jacob David , Khazanov Georgi , Abu Ghalion Fahmi , Sagy Iftach , Ben Shitrit Itamar , Fuchs Lior 
Published: June 2024

Background
ARDS is a heterogeneous syndrome with distinct clinical phenotypes. Here we investigate whether the presence or absence of large pulmonary ultrasonographic consolidations can categorize COVID-19 ARDS patients requiring mechanical ventilation into distinct clinical phenotypes.

Methods
This is a retrospective study performed in a tertiary-level intensive care unit in Israel between April and September 2020. Data collected included lung ultrasound (LUS) findings, respiratory parameters, and treatment interventions. The primary outcome was a composite of three ARDS interventions: prone positioning, high PEEP, or a high dose of inhaled nitric oxide.

Results
A total of 128 LUS scans were conducted among 23 patients. The mean age was 65 and about two-thirds were males. 81 scans identified large consolidation and were classified as “C-type”, and 47 scans showed multiple B-lines with no or small consolidation and were classified as “B-type”. The presence of a “C-type” study had 2.5 times increased chance of receiving the composite primary outcome of advanced ARDS interventions despite similar SOFA scores, Pao2/FiO2 ratio, and markers of disease severity (OR = 2.49, %95CI 1.40–4.44).

Conclusion
The presence of a “C-type” profile with LUS consolidation potentially represents a distinct COVID-19 ARDS subphenotype that is more likely to require aggressive ARDS interventions. Further studies are required to validate this phenotype in a larger cohort and determine causality, diagnostic, and treatment responses.
Os Principais Desafios e Conquistas para a Inclusão de Pessoas com Deficiência no Mercado de Trabalho
Authors: Barros Sarah Jardim Rodrigues , Silva Rogerio Sales 
Published: June 2024

O mercado de trabalho pode se apresentar de forma instável em muitos momentos, pois interage diretamente com diversos fatores externos. O mesmo mercado tem as suas peculiaridades diretamente ligadas as pessoas com deficiência. Sabendo disso, a pesquisa em questão teve como objetivo geral refletir sobre os principais desafios e conquistas para a inclusão de pessoas com deficiência no mercado de trabalho. A metodologia empregada para execução desta pesquisa deu-se através da abordagem qualitativa, sendo a sua finalidade explicativa e por meio de pesquisa bibliográfica. Por fim, concluiu-se que, qualquer indivíduo, especialmente aqueles que não possuem suas regularidades normais, têm a capacidade de mostrar o que faz de melhor, assim contribuindo para a melhoria no seu ramo de trabalho.
As Doenças Autoimunes pela ótica da Psicologia Corporal e Tradicional: Uma Revisão Integrativa
Authors: Viana Flávia Passos 
Published: June 2024

Este estudo tem como finalidade realizar uma revisão integrativa de literatura sobre o tema das doenças autoimunes e como se encontram os estudos feitos pela Psicologia Corporal e pelas demais abordagens psicológicas sobre este assunto. Foram incluídos trabalhos encontrados nas seguintes bases de dados, revistas e sites: Scientific Electronic Library Online (Scielo), Biblioteca Virtual em Saúde (BVS), Google Acadêmico, Revista Latino Americana de Psicologia Corporal; Revista Psicologia Corporal Online – Centro Reichiano, Federação Latino Americana de Análise Bioenergética, Revista de Análise Bioenergética (IIBA) e buscas em seus sites por monografias e anais de Congresso. Os estudos revisados apontam sobre a relevância e eficácia de intervenções psicológicas nos quadros de diferentes doenças autoimunes, embora na maioria dos casos não haja alteração no curso das doenças. A Psicoterapia Corporal foi a única abordagem a envolver sistematicamente trabalhos corporais e maior foco sobre o estresse e impactos antes e após a manifestação dos sintomas.
Stromal-Like Cells Are Found in Peripheral Blood of Patients With Inflammatory Bowel Disease and Correlate With Immune Activation State
Authors: Honan Amanda M. , Jacobsen Gillian E. , Drum Hannah , Vazquez Emily N. , Quintero Maria A. , Deshpande Amar R. , Sussman Daniel A. , Kerman David H. , Damas Oriana M. , Proksell Siobhan , Van der Jeught Kevin , Abreu Maria T. , Chen Zhibin 
Published: June 2024

INTRODUCTION:
Recent studies have identified a critical role of stromal-immune cell interactions in immunity and immune tolerance. Transcriptomic profiling has implicated stromal cells in immune-mediated disorders including the 2 common forms of inflammatory bowel disease (IBD), Crohn's disease (CD), and ulcerative colitis (UC). Stromal-immune interactions may edify inflammatory state and the development of IBD-related complications such as fibrosis, yet the lack of protein markers has hampered studying stromal-immune perturbation.

METHODS:
In this study, we designed a 40-color spectral flow cytometry assay to characterize hematopoietic and nonhematopoietic cells in intestinal biopsies and matched blood samples from patients with CD or UC.

RESULTS:
We identified circulating stromal-like cells that are significantly more abundant in IBD blood samples than in healthy controls. Those cells expressed podoplanin (PDPN), a commonly used marker for fibroblasts, and they were associated with activated and memory T and B cells and altered natural killer cell, monocyte, and macrophage populations. PDPN+ cells in the blood correlated with PDPN+ cells in the colon. Principal component analysis distinctly separated healthy blood samples from IBD blood samples, with stromal-like cells and B-cell subtypes dominating the IBD signature; Pearson correlation detected an association between PDPN+ stromal-like cells and B-cell populations in IBD blood and gut biopsies.

DISCUSSION:
These observations suggest that PDPN+ cells in the blood may serve as a biomarker of IBD. Understanding the relationship between stromal cells and immune cells in the intestine and the blood may provide a window into disease pathogenesis and insight into therapeutic targets for IBD.
Modeling hydrogen diffusion in precipitation hardened nickel-based alloy 718 by microstructural modeling
Authors: Arcari Attilio , Zikry Mohammed A. , Callahan Patrick G. , Horton Derek J. , Chen Muh-Jang 
Published: June 2024

Abstract
Environmentally assisted cracking can significantly affect the performance of high strength alloys and limit material selection to minimize the risk of subcritical crack growth in service. UNS N07718 is widely used in marine service applications and under a variety of conditions, such as: alternate immersion, different levels of cathodic protection, and freely corroding galvanic couples, because of its demonstrated corrosion and fracture resistance in these environments. In this work we developed a representative model of the material microstructure including the metal grains, the material texture, and the precipitates along the grain boundaries and within the grains. The microstructural model was subjected to the boundary conditions identified at the notch root of a fracture mechanics sample and the results are used as input for a simulation of hydrogen diffusion from the surface of the notch, assuming the material has been introduced to a hydrogen producing environment. The diffusion of hydrogen was modeled by Fick’s law and included both hydrostatic stress and mobile dislocation velocity as driving forces. The influence of immobile dislocations was also modeled to account for the irreversible trapping. The results show that hydrostatic stress and immobile dislocation trapping can significantly alter the highest concentration of hydrogen and its location within the microstructure towards the fracture process zone. Mobile dislocation velocity has a small influence in determining the hydrogen distribution near the fracture process zone.
Whitehead and Victorian Philosophy of Science: A Historical Investigation of the Concept of Hypothesis
Authors: Arimura Naoki 
Published: June 2024

Abstract
In the Harvard lectures of 1924–1925, Alfred North Whitehead proposed that our various intellectual activities amounted to an attempt to understand the world and our experiences through hypothesizing. He explained the importance of hypothesis in scientific research and extended the idea of hypothesis to the philosophical method called “speculative philosophy.” For Whitehead, philosophy was the attempt to formulate general hypotheses that can transcend disciplines. This paper is intended to explore the possible influence of Victorian philosophers on Whitehead. Victorian philosophers such as John Herschel, William Whewell, and John Stuart Mill discussed the role of hypothesis in scientific discovery. Was Whitehead aware of this tradition? Was he influenced by it? This article indicates that Whitehead at least indirectly inherited the Victorian idea of hypothesis, notably in the thought of Whewell, as mediated by Charles Darwin.
Interplay between male gonadal function and overall male health
Authors: Asero Vincenzo , Scornajenghi Carlo Maria , Iaconis Salvatore , Sicignano Enrico , Falcone Alfonso , Dinacci Fabrizio , Pagano Giovanni , Carino Dalila , Corvino Roberta , Tresh Anas 
Published: June 2024

Abstract
The process-of-male reproduction is intricate, and various medical conditions-have the potential to disrupt spermatogenesis. Moreover, infertility in males can serve as an indicator of-potential future health issue. Numerous conditions with systemic implications have been identified, encompassing genetic factors (such as Klinefelter Syndrome), obesity, psychological stress, environmental factors, and others. Consequently, infertility assessment-presents an opportunity for comprehensive health counseling, extending-beyond discussions about reproductive goals. Furthermore, male infertility has been suggested as a harbinger of future health problems, as poor semen quality and a diagnosis of-male infertility are associated with an increased risk of hypogonadism, cardiometabolic disorders, cancer, and even mortality. This review explores the existing-literature on the relationship between systemic illnesses and male fertility, impacting both clinical-outcomes and semen parameters. The majority of the literature analyzed, which compared gonadal function with genetic, chronic, infectious or tumoral diseases, confirm the association between overall male health and infertility.
The relationship between bisphenol A and phthalates with precocious puberty in Vietnamese children
Authors: Vu Huynh Quynh Thi , Ban Ho Tran , Vuong Nguyen Lam , Khanh Nguyen Phuong 
Published: June 2024

Abstract

Objectives
This study is aimed to explore the correlation between bisphenol A (BPA) and phthalates, including diethylhexylphthalate (DEHP) and dibutylphthalate (DBP), and precocious puberty (PP).

Methods
A case-control study was conducted in Ho Chi Minh City, Vietnam, from November 2021 to April 2022, involving 250 children, with 124 of them diagnosed with PP and 126 serving as controls. We assessed the levels of urinary BPA, DEHP, and DBP in all participants and examined their association with the risk of PP.

Results
BPA was detected in 11.3 % of PP cases but was not found in any individuals in the control group (p<0.001). Diethylhexylphthalate metabolite (MEHP) was not detected in any of the samples. Positive urinary results for dibutylphthalate metabolite (MBP) were observed in 8.1 % of PP cases and 2.4 % in the control group, with an odds ratio of 3.6 (95 % confidence interval: 0.97–13.4, p=0.03).

Conclusions
The PP group exhibited a higher prevalence of positive urinary BPA and DBP levels compared to the control group.
Investigating pausing and gesturing patterns in children with and without developmental language disorder
Authors: Bellifemine Corrado , Kosmala Loulou 
Published: June 2024

Abstract
This study aims at observing the co-occurrence of filled (FP) and unfilled pauses (UP) and gestures in the narratives of children with and without Developmental Language Disorder (DLD). Although children with DLD are known to be more “disfluent” than typically developing children (TD), little is known about the role of pauses in children’s speech and their interaction with gestures. 22 French-speaking children with DLD and 22 age- and gender-matched controls, between 7 and 10, recounted a cartoon excerpt. We annotated pauses and their position in utterances, and we coded gestures according to their function. Despite a similar pausing rate across groups, results show that TD children produced more utterance-beginning FPs and more mid-utterance UPs, while children with DLD produced more standalone FPs and mid-utterance UPs. Furthermore, multimodal patterns of co-occurrence, specific to pause type, emerged. While both groups had similar gesture rates and produced mostly referential gestures, TD children produced slightly more beat gestures during FPs and more self-adaptors and pragmatic gestures during UPs. Children with DLD produced more referential gestures and object-adaptors during UPs. These differences point to the temporal relationship between gestures and pauses and the multiple ways these two phenomena may interact according to the child’s profile.
Novel analytic solutions of strain wave model in micro-structured solids
Authors: Rabie Wafaa B. , Ahmed Hamdy M. , Hussein Hisham H. 
Published: June 2024

Abstract
In this article, the modified extended direct algebraic method is implemented to investigate the strain wave model that governs the wave propagation in micro-structured solids. The proposed method provides many new exact traveling wave solutions with certain free parameters. Exact solutions are extremely important in interpreting the inner structures of the natural phenomena. Solitary and other wave solutions are provided for this model, such as bright solitary solutions, dark solitary solutions, singular solitary solutions, singular-dark combo solitary solutions. Also, periodic solutions and Jacobi elliptic function solutions are presented. To show the physical characteristics of the raised solutions, the graphical illustration of some solutions is presented.
Mixing performance in an asymmetrical non-twin kneading element channel
Authors: Liang Ruifeng , Yu Huiwen , Xiao Shuping , Huang Jiarong , Xu Baiping 
Published: June 2024

Abstract
The kneading elements play a crucial role in the distributive and dispersive mixing in the conventional co-rotating twin screw extruders. A novel kind of asymmetrical dual-speed co-rotating non-twin kneading elements (NTKE) with a zero staggered angle was designed to introduce symmetry break to improve mixing. Finite element method was applied to solve the time-dependent flow field where mesh superposition technique was used to impose the boundary conditions of moving parts and further to avoid the remeshing at every time steps. The flow and mixing of several fluids obeying the Carreau constitutive model with the different power law exponents were investigated numerically and compared with the conventional co-rotating twin kneading elements (TKE). Distributive mixing was evaluated through evolution of tracer droplets and decaying of variance index with time. Moreover, the dispersive mixing was examined in terms of the statistical distributions of mixing index. An integral function with regard to the mixing index was proposed to evaluate the proportion of tracer particles subjected to the elongation.
Stochastic simulation of exciton transport in semiconductor heterostructures
Authors: Sabelfeld Karl , Aksyuk Ivan 
Published: June 2024

Abstract
Stochastic simulation algorithm for solving exciton transport in a 3D layered semiconductor heterostructure is developed. The problem is governed by a transient drift-diffusion-recombination equation with Dirichlet and Neumann mixed boundary conditions. The semiconductor is represented as an infinite multilayer of finite thickness along the transverse coordinate z. The multilayer is composed by a set of sublayers of different materials so that the excitons have different diffusion and recombination coefficients in each layer. Continuity of solutions and fluxes at the plane interfaces between layers are imposed. The stochastic simulation algorithm solves the transport problem by tracking exciton trajectories in accordance with the probability distributions represented through the Green function of the problem in each sublayer. The method is meshless, the excitons jump only over the plane boundaries of the layers. This explains the high efficiency of the method. Simulation results for transport problems with different mixed boundary conditions are presented.
Возвратность в зоне интерференции (на материале двуязычных польско-украинских текстов середины XIX в.)
Authors: ОСТАПЧУК Оксана 
Published: June 2024

В статье анализируется образование и функционирование соотносимых возвратных и невозврат-ных форм глаголов в параллельных польско-украинских текстах середины XIX в., созданных писа-телями так называемой украинской школы Т. Падуррой (1801–1871) и С. Осташевским (1797–1875). Проведено сопоставление обнаруженных примеров нарушения оппозиции в сфере возвратности с лексикографическими материалами и данными корпуса украинского и польского языков, подтвер-дившие узуальный, а не индивидуально-авторский характер инноваций в данной контактной зоне. Двуязычие авторов анализируемых текстов объясняет тот факт, что среди специфических особен-ностей в сфере возвратности значительное место занимают польско-украинские интерферемы и явления аналогичного характера, фиксируемые также в региональном узусе. Исходя из проанализи-рованных примеров, возвратность в целом можно охарактеризовать как одну из зон межъязыковой «напряженности» в глагольной сфере.Контактные формы отмечены в анализируемых текстах как в сфере словоизменения, так и на уровне морфосинтаксиса. Наиболее ярко межъязыковое взаимодействие проявляется в нарушении оппозиции возвратных и невозвратных глаголов. Наш материал подтвердил тенденцию к более ред-кому опущению возвратного элемента в обоих языках. В свою очередь, поддерживающее влияние может способствовать появлению усиленных за счет возвратной частицы форм как переходных, так и непереходных глаголов. При этом направление влияния может быть установлено не во всех случаях: наряду с очевидными примерами, демонстрирующими следование одному из образцов: польскому или украинскому, широко распространено взаимонаправленное воздействие.В тех случаях, когда оба языка демонстрируют вариативность, украинские рефлексивы, как пра-вило, носят региональный (западный) характер, реже – маркированы в обоих языках. Усиление вариативности глагольных форм, характерное для украинского регионального узуса, объясняется географическим положением и социолингвистическими характеристиками данного региона. В це-лом ряде случаев появление новых вариантных (дополнительно маркированных) форм является результатом действия лексической аналогии и словообразовательной синонимии, как, например, при производстве префиксально-постфиксальных дериватов с кумулятивным значением от пере-ходных невозвратных глаголов. Эта тенденция распространяется также на непереходные глаголы (например, глаголы движения и состояния), где рефлексивы оказываются маркированными чле-нами оппозиции в обоих языках. Семантические трансформации, связанные с образованием реф-лексивов от глаголов такого рода, могут также оказывать воздействие на сферу морфосинтаксиса, приводя к увеличению частотности имперсональных субъектных конструкций и расширению чис-ла глаголов, задействованных в их образовании.
PTFE-g-GMA graft copolymer synthesis promoted by oxidative gamma-rays method and characterization
Authors: Ibarra-Cervantes Tamara B. S. , Flores-Rojas Guadalupe G. , Mendizabal Eduardo , Bucio Emilio 
Published: June 2024

AbstractThe functionalization of polymeric matrices through graft polymerization offers various advantages by providing new properties, allowing for additional chemical reactions that the matrix alone could not undergo or that would require drastic chemical conditions to occur. In this work, epoxy groups were incorporated through a graft polymer of poly(glycidyl methacrylate), using a prefunctionalization with peroxide groups in the polytetrafluoroethylene matrix through gamma radiation. These peroxide groups were subsequently used as radical chemical initiators in the graft polymerization reaction of glycidyl methacrylate. The graft polymerization reaction was studied based on the absorbed dose, monomer concentration, reaction time, and temperature.
Graphical abstract