bluuebunny/crossref_metadata_2025_split huggingface dataset:
Relative contribution of COVID-19 vaccination and SARS-CoV-2 infection to population-level seroprevalence of SARS-CoV-2 spike antibodies in a large integrated health system
Authors: Chervo Tyler C. , Elkin Eric P. , Nugent Joshua R. , Valice Emily , Amsden Laura B. , Ergas Isaac J. , Munneke Julie R. , Flores Monica , Saelee Gina N. , Hsiao Crystal A. , Schapiro Jeffery M. , Quesenberry Charles P. , Corley Douglas A. , Habel Laurel A. , Kushi Lawrence H. , Skarbinski Jacek 
Published: June 2024

Background
Understanding the relative contributions of SARS-CoV-2 infection-induced and vaccine-induced seroprevalence is key to measuring overall population-level seroprevalence and help guide policy decisions.

Methods
Using a series of six population-based cross-sectional surveys conducted among persons aged ≥7 years in a large health system with over 4.5 million members between May 2021 and April 2022, we combined data from the electronic health record (EHR), an electronic survey and SARS-CoV-2 spike antibody binding assay, to assess the relative contributions of infection and vaccination to population-level SARS-CoV-2 seroprevalence. EHR and survey data were incorporated to determine spike antibody positivity due to SARS-CoV-2 infection and COVID-19 vaccination. We used sampling and non-response weighting to create population-level estimates.

Results
We enrolled 4,319 persons over six recruitment waves. SARS-CoV-2 spike antibody seroprevalence increased from 83.3% (CI 77.0–88.9) in May 2021 to 93.5% (CI 89.5–97.5) in April 2022. By April 2022, 68.5% (CI 61.9–74.3) of the population was seropositive from COVID-19 vaccination only, 13.9% (10.7–17.9) from COVID-19 vaccination and prior diagnosed SARS-CoV-2 infection, 8.2% (CI 4.5–14.5) from prior diagnosed SARS-CoV-2 infection only and 2.9% (CI 1.1–7.6) from prior undiagnosed SARS-CoV-2 infection only. We found high agreement (≥97%) between EHR and survey data for ascertaining COVID-19 vaccination and SARS-CoV-2 infection status.

Conclusions
By April 2022, 93.5% of persons had detectable SARS-CoV-2 spike antibody, predominantly from COVID-19 vaccination. In this highly vaccinated population and over 18 months into the pandemic, SARS-CoV-2 infection without COVID-19 vaccination was a small contributor to overall population-level seroprevalence.
Screening instruments of cognition: The relation of the mini-mental state examination to the Edinburgh cognitive and behavioural ALS screen in amyotrophic lateral sclerosis
Authors: Serian Angela , Finsel Julia , Ludolph Albert C. , Uttner Ingo , Lulé Dorothée 
Published: June 2024

Objective
The Edinburgh Cognitive and Behavioural ALS Screen (ECAS) is an established cognitive screening instrument for patients with amyotrophic lateral sclerosis (ALS). Different from tools like the Mini-Mental State Examination (MMSE), it is adjusted for motor impairment, yet, the latter remains one of the most widely used screening instruments, also in ALS studies. Thus, it is of utmost importance to relate outcome scores of both instruments to allow for comparison in ALS patients. This study reports on the performance of ALS patients in both tests with regard to incidence and degree of cognitive impairment, and the correspondence of both, ECAS and MMSE scores.

Methods
We examined N = 84 ALS patients with the German versions of the ECAS and the MMSE. Performance in both tests regarding incidence and degree of cognitive impairment, and correspondence of frequency of cognitive impairment according to both tests was examined. The relationship between ECAS and MMSE scores was modelled with a non-linear regression model.

Results
All ALS patients were able to complete the ECAS, 89.3% (N = 75) were capable to complete the MMSE. Prevalence of cognitive impairment was in both tests 22.7%, however agreement was only 52.9%. Despite, regression analyses yielded a strong positive relationship (adjusted R2 = .68) between the ECAS total score and the MMSE total score. Both tests were able to identify all patients with dementia.

Conclusion
These results suggest that the MMSE is not ideal for cognitive screening in early-stage ALS patients. However, a rough translation of MMSE scores in ECAS scores is possible to estimate the cognitive performance level of patients, with the ECAS being more discriminative in the lower range of cognitive dysfunction (ECAS score: 80–136), for which the MMSE does not define cognitive impairment (corresponding MMSE score: 27–30).
Incidence of venous thromboembolism and bleeding in patients with malignant central nervous system neoplasm: Systematic review and meta-analysis
Authors: Veiga Viviane Cordeiro , Peres Stela Verzinhasse , Ostolin Thatiane L. V. D. P. , Moraes Flavia Regina , Belucci Talita Rantin , Clara Carlos Afonso , Cavalcanti Alexandre Biasi , Chaddad-Neto Feres Eduardo Aparecido , Batistella Gabriel N. de Rezende , Neville Iuri Santana , Baeta Alex M. , Yamada Camilla Akemi Felizardo ,   on behalf of the TROMBOGLIO Study Group
Published: June 2024

Purpose
Central nervous system (CNS) malignant neoplasms may lead to venous thromboembolism (VTE) and bleeding, which result in rehospitalization, morbidity and mortality. We aimed to assess the incidence of VTE and bleeding in this population. Methods: This systematic review and meta-analysis (PROSPERO CRD42023423949) were based on a standardized search of PubMed, Virtual Health Library and Cochrane (n = 1653) in July 2023. After duplicate removal, data screening and collection were conducted by independent reviewers. The combined rates and 95% confidence intervals for the incidence of VTE and bleeding were calculated using the random effects model with double arcsine transformation. Subgroup analyses were performed based on sex, age, income, and type of tumor. Heterogeneity was calculated using Cochran’s Q test and I2 statistics. Egger’s test and funnel graphs were used to assess publication bias. Results: Only 36 studies were included, mainly retrospective cohorts (n = 30, 83.3%) from North America (n = 20). Most studies included were published in high-income countries. The sample size of studies varied between 34 and 21,384 adult patients, mostly based on gliomas (n = 30,045). For overall malignant primary CNS neoplasm, the pooled incidence was 13.68% (95%CI 9.79; 18.79) and 11.60% (95%CI 6.16; 18.41) for VTE and bleeding, respectively. The subgroup with elderly people aged 60 or over had the highest incidence of VTE (32.27% - 95%CI 14.40;53.31). The studies presented few biases, being mostly high quality. Despite some variability among the studies, we observed consistent results by performing sensitivity analysis, which highlight the robustness of our findings. Conclusions: Our study showed variability in the pooled incidence for both overall events and subgroup analyses. It was highlighted that individuals over 60 years old or diagnosed with GBM had a higher pooled incidence of VTE among those with overall CNS malignancies. It is important to note that the results of this meta-analysis refer mainly to studies carried out in high-income countries. This highlights the need for additional research in Latin America, and low- and middle-income countries.
Lick It: Challenge the Way You Experience Food, Marijie Vogelzang (2022)
Authors: Mei Ran 
Published: June 2024

Review of: Lick It: Challenge the Way You Experience Food, Marijie Vogelzang (2022)
Amsterdam: BIS Publishers, 224 pp.,
ISBN 978-9-06369-650-4, p/bk, €19.99
Acoustic Detection and Quantification of Fish in Lancang Waters of Seribu Islands, Indonesia
Authors: Purnawan Syahrul , Manik Henry M. , Manik Agustina Sartika , Elson La , Kang Myounghee 
Published: June 2024

Sound propagates effectively through the water column, establishing hydroacoustic technology as a premier method for underwater exploration, including the mapping of aquatic ecological resources. While the fisheries sector is considered pivotal in aquatic resource studies, mapping fisheries remains challenging due to the distinct distribution patterns exhibited by fish within the water column, which are intricately linked to their habitat preferences. In this study, the hydroacoustic method was employed to analyze the distribution of fish in the waters surrounding Lancang Island, Seribu Islands, Jakarta. This analysis utilized the target strength (TS) value alongside oceanographic parameters. Acoustic data was collected using a 200 kHz single beam echosounder based on parallel transects encircling the waters of Lancang Island. CTD was utilized to collect oceanographic data to acquire temperature and salinity profiles within the water column. The acoustic data processing was conducted using the post-processing software SONAR 5-pro. The analysis was performed based on acoustic cells, obtained by dividing segments every 100 m horizontally and layers every 5 m vertically, thereby obtaining the Target Strength per cell (TSc) and volume backscattering strength (SV) values from each cell. The results showed that the highest average TSc value was found in the depth range of 26-31 m at -46.98 dB, and the highest SED biomass was also found in the same depth range at 26.6 kg.ha-1. Based on the analysis of water temperature and salinity, it was found that these factors significantly influence the distribution of fish in the waters of Lancang Island (R-square= 0.1276 and P< 0.05). This finding also indicates the presence of other parameters affecting fish distribution in Lancang waters, with the type of substrate and habitat emerging as potential determining factors, notably in coral reef environments.
The role of pannexin/purinergic signaling in intervascular communication from capillaries during skeletal muscle contraction in male Golden hamsters
Authors: Lamb Iain R. , Novielli‐Kuntz Nicole M. , Murrant Coral L. 
Published: June 2024

AbstractWe sought to determine the physiological relevance of pannexin/purinergic‐dependent signaling in mediating conducted vasodilation elicited by capillary stimulation through skeletal muscle contraction. Using hamster cremaster muscle and intravital microscopy we stimulated capillaries through local muscle contraction while observing the associated upstream arteriole. Capillaries were stimulated with muscle contraction at low and high contraction (6 and 60CPM) and stimulus frequencies (4 and 40 Hz) in the absence and presence of pannexin blocker mefloquine (MEF; 10−5 M), purinergic receptor antagonist suramin (SUR 10−5 M) and gap‐junction uncoupler halothane (HALO, 0.07%) applied between the capillary stimulation site and the upstream arteriolar observation site. Conducted vasodilations elicited at 6CPM were inhibited by HALO while vasodilations at 60CPM were inhibited by MEF and SUR. The conducted response elicited at 4 Hz was inhibited by MEF while the vasodilation at 40 Hz was unaffected by any blocker. Therefore, upstream vasodilations resulting from capillary stimulation via muscle contraction are dependent upon a pannexin/purinergic‐dependent pathway that appears to be stimulation parameter‐dependent. Our data highlight a physiological importance of the pannexin/purinergic pathway in facilitating communication between capillaries and upstream arteriolar microvasculature and, consequently, indicating that this pathway may play a crucial role in regulating blood flow in response to skeletal muscle contraction.
Measurement of arterial occlusion pressure using straight and curved blood flow restriction cuffs
Authors: Vehrs Pat R. , Hager Ron , Richards Nathan Dayne , Richards Shay , Baker Luke , Burbank Tyler , Clegg Shelby , Frazier Isabelle Katherine , Nielsen Josh Richard , Watkin Jessica Harkleroad 
Published: June 2024

AbstractArterial occlusion pressure (AOP) is influenced by the characteristics of the cuff used to measure AOP. Doppler ultrasound was used to measure AOP of the brachial and superficial femoral arteries using straight and curved blood flow restriction cuffs in 21 males and 21 females. Vessel diameter and blood flow were evaluated as independent predictors of AOP. Overall, there were no significant differences in AOP when using the straight and curved cuffs in the brachial (129 mmHg vs. 128 mmHg) or superficial femoral artery (202 mmHg vs. 200 mmHg), respectively. Overall, AOP was greater (p < 0.05) in males than in females in the arm (135 mmHg, 123 mmHg) and leg (211 mmHg, 191 mmHg). Brachial (0.376 mm, 0.323 mm) and superficial femoral (0.547 mm, 0.486 mm) arteries were larger (p = 0.016) in males than in females, respectively. Systolic blood pressure (SBP) and arm circumference were predictive of brachial artery AOP, whereas SBP, diastolic blood pressure, thigh circumference, and vessel diameter were predictive of superficial femoral artery AOP. Straight and curved cuffs are efficacious in the measurement of AOP in the arm and leg. Differences in vessel size may contribute to sex differences in AOP but this requires further investigation.
Direct and acute effects of advanced glycation end products on proteostasis in isolated mouse skeletal muscle
Authors: Zhao Haiyu , Iyama Ryota , Kurogi Eriko , Hayashi Tatsuya , Egawa Tatsuro 
Published: June 2024

AbstractAdvanced glycation end products (AGEs) have been implicated in several skeletal muscle dysfunctions. However, whether the adverse effects of AGEs on skeletal muscle are because of their direct action on the skeletal muscle tissue is unclear. Therefore, this study aimed to investigate the direct and acute effects of AGEs on skeletal muscle using an isolated mouse skeletal muscle to eliminate several confounders derived from other organs. The results showed that the incubation of isolated mouse skeletal muscle with AGEs (1 mg/mL) for 2–6 h suppressed protein synthesis and the mechanistic target of rapamycin signaling pathway. Furthermore, AGEs showed potential inhibitory effects on protein degradation pathways, including autophagy and the ubiquitin–proteasome system. Additionally, AGEs stimulated endoplasmic reticulum (ER) stress by modulating the activating transcription factor 6, PKR‐like ER kinase, C/EBP homologous protein, and altered inflammatory cytokine expression. AGEs also stimulated receptor for AGEs (RAGE)‐associated signaling molecules, including mitogen‐activated protein kinases. These findings suggest that AGEs have direct and acute effect on skeletal muscle and disturb proteostasis by modulating intracellular pathways such as RAGE signaling, protein synthesis, proteolysis, ER stress, and inflammatory cytokines.
FMS-like tyrosine kinase 3 inhibitory potentials of some phytochemicals from anti-leukemic plants using computational chemical methodologies
Authors: Umar Haruna Isiyaku , Ashimiyu-Abdusalam Zainab , Alaqarbeh Marwa , Magani Wanche Ernest , Victor Omoboyede , Omotosho-Sanni Rukayat Yetunde , Bello Ridwan Opeyemi , Jardan Yousef A. Bin , Ibenmoussa Samir , Bourhia Mohammed , Wondmie Gezahign Fentahun , Bouachrine Mohammed 
Published: June 2024

Abstract
Acute myeloid leukemia (AML) takes center stage as a highly prevalent and aggressive clonal disorder affecting hematological stem cells. FMS-like tyrosine kinase 3 (FLT3) mutations were prevalent in nearly 30% of the AML cases. However, efforts have led to the development of anti-mutant FLT3 drugs, such as midostaurin, gilteritinib, and quizartinib, to improve treatments. Currently, we are exploring the ability of compounds from anti-leukemic plants to be used in AML therapies, focusing on mutant FLT3 inhibition. Employing computational techniques such as drug-likeness assessment, molecular docking, pharmacokinetics properties profiling, molecular dynamics simulations (MDS), and free energy calculations, we identified 43 out of 57 compounds with oral drug potential. Notably, 7 out of 43 compounds, including flavopiridol, sanggenol Q, norwogonin, oblongixanthones A, oblongixanthones B, apigenin, and luteolin exhibited strong binding affinities ranging from −9.0 to −9.8 kcal/mol, surpassing the control drug gilteritinib (−6.3 kcal/mol). Notably, flavopiridol and norwogonin displayed highly favorable pharmacokinetics and low toxicity profiles. MDS confirmed the stability of their binding through parameters such as root mean square deviation, root mean square fluctuation, and radius of gyration (R
g) over 100 ns simulations. Flavopiridol and norwogonin emerge as promising candidates for the development of mutant FLT3 inhibitors. Therefore, experimental studies are warranted to validate their therapeutic potential.
Recruitment of students of color into the teaching profession: analysis of the “Like Me” program
Authors: Laverick Vincent T. 
Published: June 2024

Abstract
The “Like Me: Diversifying the Educator Workforce” program was developed at Lourdes University to address the disparate proportion of teachers of color in local classrooms as compared to the students of color. To gauge the impact of “Like Me” recruitment efforts, faculty at Lourdes University conducted a qualitative study eliciting information about how students applied to the program, factors that influenced their decision-making, and reasons behind their selection of education as a career. The findings underlined the strong influence that trusted adults play in the recruitment process. Additionally, financial support was an important factor in facilitating enrollment in the program.
A Biomechanical Comparison Between a High and Low Barbell Placement on Net Joint Moments, Kinematics, Muscle Forces, and Muscle-Specific Moments in 3 Repetition Maximum Back Squats
Authors: Larsen Stian , de Zee Mark , Kristiansen Eirik Lindset , van den Tillaar Roland 
Published: June 2024

Abstract
Larsen, S, de Zee, M, Kristiansen, EL, and van den Tillaar, R. A biomechanical comparison between a high and low barbell placement on net joint moments, kinematics, muscle forces, and muscle-specific moments in 3 repetition maximum back squats. J Strength Cond Res 38(7): 1221–1230, 2024—This study aimed to investigate the impact of a high barbell vs. low barbell placement on net joint moments, muscle forces, and muscle-specific moments in the lower extremity joints and muscles during maximum back squats. Twelve recreationally trained men (age = 25.3 ± 2.9 years, height = 1.79 ± 7.7 m, and body mass = 82.8 ± 6.9 kg) volunteered for the study. A marker-based motion capture system and force plate data were used to calculate the net joint moments, and individual muscle forces were estimated using static optimization. Muscle forces were multiplied by their corresponding internal moment arms to determine muscle-specific moments. Statistical parametric mapping was used to analyze the effect of barbell placement as time-series data during the concentric phase. The 3 repetition maximum barbell load lifted by the subjects was 129.1 ± 13.4 kg and 130.2 ± 12.7 kg in the high bar and low bar, which were not significantly different from each other. Moreover, no significant differences were observed in net joint moments, muscle forces, or muscle-specific moments for the hip, knee, or ankle joint between the low- and high bar placements. The findings of this study suggest that barbell placement plays a minor role in lower extremity muscle forces and moment-specific moments when stance width is standardized, and barbell load lifted does not differ between barbell placements among recreationally resistance-trained men during maximal back squats. Therefore, the choice of barbell placement should be based on individual preference and comfort.
A New Blade Design for Municipal Solid Waste Bag Opener Machines: A Static and Fatigue Finite Element Analysis Study
Authors: Hefzi Assem A , Marzok Wagih W , Badran Ahmed H 
Published: June 2024

Municipal solid waste (MSW) presents a global challenge, carrying health and environmental risks without proper recycling and disposal methods. Mechanical-biological treatment (MBT) emerges as a promising solution capable of recycling MSW and reducing landfill volumes. However, the efficiency of MBT heavily relies on the bag opener machine, which extracts waste from bags. Therefore, enhancing the bag opener machine's performance is crucial for optimizing the MBT process. This paper introduces four blade models (A, B, C, and D) with different cutting angles (60°, 50°, 45°, and 30°, respectively) aimed at achieving high efficiency, low power consumption, minimal maintenance costs, and extended service life. The blade design was developed using the 3-D modeling software, SOLIDWORKS. Additionally, the paper presents primary calculations of the bag opener machine, which were informed by a review of MSW characterization studies. Static and fatigue finite element analyses (FEAs) were conducted under a pressure of 1 MPa to assess blade strength, performance, and durability. The results indicate that the proposed design can handle a capacity of approximately 30 tons/hr with a power consumption of 22 kW. Notably, blade model D, featuring the minimum cutting angle of 30°, exhibits the lowest Von Mises maximum stress at 15.18 MPa and the minimum factor-of-safety (FOS) at 18.12. Fatigue stress analysis reveals a life expectancy of 106 cycles for all blade models. In conclusion, model D demonstrates superior strength, FOS, and durability, making it the optimal choice for the bag opener machine.
Adrenocortical carcinoma: selective internal radiation therapy and liver metastases
Authors: Baxendale-Smith Leo , El-Shakankery Karim , Gordon-Smith James , Wall Lucy 
Published: June 2024

Selective internal radiation therapy (SIRT) is a novel intervention for both primary and metastatic malignant liver lesions. Adrenocortical carcinoma (ACC) is rare with limited treatment options; evidence for SIRT in ACC liver metastases consists of case reports only. Selective internal radiation therapy (SIRT) was employed to treat recurrent liver metastases in a 49-year-old gentleman with ACC, who previously underwent a left-sided hepatectomy. The patient opted for SIRT after reviewing the literature regarding mitotane chemotherapy and its toxicities. Selective internal radiation therapy (SIRT) provided several months of progression-free survival (PFS), with no toxicity and an excellent radiological response. The patient re-presented 12 years after the initial diagnosis with skeletal metastases and sadly died in September 2022. Substantial unmet need exists for effective treatments in ACC, with 75% of patients presenting with incurable disease. Developing widespread disease, SIRT offered 2 years’ PFS in our patient; this was well tolerated with minimal residual liver impairment. Its use in ACC liver-limited disease warrants investigation.

Significance statement
Adrenocortical carcinoma (ACC) is a rare and aggressive tumour with limited treatments. Once metastatic disease develops, existing standard-of-care treatments offer a dismal overall survival, alongside marked toxicities. Selective internal radiation therapy (SIRT) may represent a new intervention in the treatment paradigm for liver-limited, metastatic ACC. Here, we present the case of a patient treated with multiple rounds of SIRT for relapsed, liver-limited ACC, prolonging survival by several years. Recurrent SIRT led to maintained liver function and no toxicities. Little evidence outlines its use in ACC but further study is certainly warranted to ascertain the value of SIRT, considering the limited treatment landscape that currently exists.