bluuebunny/crossref_metadata_2025_split huggingface dataset:
Signalling switches maintain intercellular communication in the vascular endothelium
Authors: Buckley Charlotte , Lee Matthew D. , Zhang Xun , Wilson Calum , McCarron John G. 
Published: April 2024

AbstractBackground and PurposeThe single layer of cells lining all blood vessels, the endothelium, is a sophisticated signal co‐ordination centre that controls a wide range of vascular functions including the regulation of blood pressure and blood flow. To co‐ordinate activities, communication among cells is required for tissue level responses to emerge. While a significant form of communication occurs by the propagation of signals between cells, the mechanism of propagation in the intact endothelium is unresolved.Experimental ApproachPrecision signal generation and targeted cellular manipulation was used in conjunction with high spatiotemporal mesoscale Ca2+ imaging in the endothelium of intact blood vessels.Key ResultsMultiple mechanisms maintain communication so that Ca2+ wave propagation occurs irrespective of the status of connectivity among cells. Between adjoining cells, regenerative IP3‐induced IP3 production transmits Ca2+ signals and explains the propagated vasodilation that underlies the increased blood flow accompanying tissue activity. The inositide is itself sufficient to evoke regenerative phospholipase C‐dependent Ca2+ waves across coupled cells. None of gap junctions, Ca2+ diffusion or the release of extracellular messengers is required to support this type of intercellular Ca2+ signalling. In contrast, when discontinuities exist between cells, ATP released as a diffusible extracellular messenger transmits Ca2+ signals across the discontinuity and drives propagated vasodilation.Conclusion and ImplicationsThese results show that signalling switches underlie endothelial cell‐to‐cell signal transmission and reveal how communication is maintained in the face of endothelial damage. The findings provide a new framework for understanding wave propagation and cell signalling in the endothelium.
Leaf traits and leaf‐to‐air temperature differences in tropical plants suggest variability in thermoregulatory capacities across elevations
Authors: Pedraza Sara 
Published: April 2024

AbstractPlant thermoregulation is essential for understanding the potential effects of climate change on terrestrial ecosystems. This study provides evidence indicating variation of leaf functional traits and leaf‐to‐air temperature across the elevation gradient. These results support the existence of distinct plant adaptations for thermoregulation across different elevation zones.Abstract in Spanish is available with online material.
Choosing Among Undesirable Options: Children Consider Desirability of Available Choices in Evaluation of Socially Mindful Actions
Authors: Li Sixian , Zhao Xin 
Published: April 2024

AbstractPrevious studies show that adults and children evaluate the act of leaving a choice for others as prosocial, and have termed such actions as socially mindful actions. The current study investigates how the desirability of the available options (i.e., whether the available options are desirable or not) may influence adults’ and children's evaluation of socially mindful actions. Children (N = 120, 4‐ to 6‐year‐olds) and adults (N = 124) were asked to evaluate characters selecting items for themselves from a set of three items—two identical items and one unique item—in a way that either leaves a choice (two diverse items) or leaves no choice (two identical items) for the next person (i.e., the beneficiary). We manipulated whether the available options were either desirable or undesirable (i.e., damaged). We found that adults’ and 6‐year‐olds’ evaluation of socially mindful actions is moderated by the desirability of the options. Although they evaluate the act of leaving a choice for others as nicer than the act of leaving no choice both when the choosing options are desirable and when they are undesirable, the discrepancy in the evaluation becomes significantly smaller when the choosing options are undesirable. We also found that inference of the beneficiary's feeling underlies social evaluation of the actor leaving a choice (or not). These findings suggest that children consider both the diversity of options left and the desirability of the available options in understanding and evaluating socially mindful acts.
A pharmacokinetic study comparing the biosimilar HEC14028 and Dulaglutide (Trulicity®) in healthy Chinese subjects
Authors: Gao Xianglei , Di Yujing , Lv Yuan , Luan Yingcai , Xiong Yang , Xu Yuli , Li Yusheng , Guo Linfeng , Li Xiaoping , Deng Li , Zhuang Yulei , Hou Jie 
Published: April 2024

AbstractThis study aimed to evaluate the pharmacokinetics (PKs), safety, and immunogenicity of the biosimilar HEC14028 compared to reference Trulicity® (dulaglutide) in healthy male Chinese subjects. This study was a single‐center, randomized, open, single‐dose, parallel‐controlled comparative Phase I clinical trial, including a screening period of up to 14 days, a 17‐day observation period after administration, and a 7‐day safety follow‐up period. A total of 68 healthy male subjects were randomly assigned (1:1) to the test group (HEC14028) and the reference group (dulaglutide) (single 0.75 mg abdominal subcutaneous dose). The primary objective was to evaluate the pharmacokinetic characteristics of HEC14028 and compare the pharmacokinetic similarities between HEC14028 and dulaglutide. The primary PK endpoints were maximum plasma concentration (Cmax) and area under the blood concentration‐time curve from zero time to the estimated infinite time (AUC0–∞). The study results showed that HEC14028 and dulaglutide were pharmacokinetically equivalent: 90% confidence interval (CI) of Cmax and AUC0–∞ geometric mean ratios were 102.9%–122.0% and 97.1%–116.9%, respectively, which were both within the range of 80.00%–125.00%. No grade 3 or above treatment emergent adverse events (TEAEs), serious adverse events (SAEs), TEAEs leading to withdrawal from the trial, or TEAEs leading to death were reported in this study. Both HEC14028 and dulaglutide showed good and similar safety profiles, and no incremental immunogenicity was observed in subjects receiving HEC14028 and dulaglutide.
Prevention of axonal loss after immediate dosage titration of immunoglobulin in multifocal motor neuropathy
Authors: Al‐Zuhairy Ali , Jakobsen Johannes , Krarup Christian 
Published: April 2024

AbstractBackgroundTo evaluate whether ongoing axonal loss can be prevented in multifocal motor neuropathy (MMN) treated with immunoglobulin G (IgG), a group of patients with a median disease duration of 15.7 years (range: 8.3–37.8), treated with titrated dosages of immunoglobulins, was studied electrophysiologically at time of diagnosis and at follow‐up.ResultsAt follow‐up, the Z‐score of the compound motor action potential amplitude of the median, fibular, and tibial nerves and the neurological performances were determined. In seven patients with a treatment‐free period of 0.3 years (0.2–0.4), there was no progression of axonal loss (p = 0.2), whereas a trend toward further axonal loss by 1.3 Z‐scores (0.9–17.0, p = 0.06) was observed in five patients with a treatment‐free period of 4.0 years (0.9–9.0). The axonal loss in the group with a short treatment delay was significantly smaller than in the group with a longer treatment delay (p = 0.02). Also, there was an association between treatment delay and ongoing axonal loss (p = 0.004). The electrophysiological findings at follow‐up were associated with the isokinetic strength performance, the neurological impairment score, and the disability, supporting the clinical relevance of the electrophysiological estimate of axonal loss.ConclusionSwift initiation of an immediately titrated IgG dosage can prevent further axonal loss and disability in continuously treated MMN patients.
A family reunion of “clinical cousins”: Attachment and emotion in four family‐oriented therapy models
Authors: Sabey Allen K. , Lafrance Adele , Furrow James , Diamond Guy , Hughes Daniel 
Published: April 2024

AbstractAttachment theory and the science of emotion provide a strong foundation for intervention at the family system level. Four therapeutic models in particular, Attachment‐Based Family Therapy, Emotion‐Focused Family Therapy, Dyadic Developmental Psychotherapy, and Emotionally Focused Family Therapy, demonstrate how a broad and accurate view of attachment relationships and emotion can be utilized to effectively intervene for a variety of presenting problems in a relational and empathic way for all involved. This paper continues a conversation that began at the Summit for Attachment and Emotion in Family Therapy in 2021 and aims to foster openness, collaboration, and affirmation between four different models of family therapy with shared theoretical roots. The presenters at the Summit and the authors of this paper view similarities across these models as validating and differences as opportunities to serve more families in unique ways, learning from one another's creativity to promote healing within families in the most effective and efficient ways possible. The paper frames the value of attachment theory and emotion science for family therapy, discusses the importance of learning from a variety of models with shared theoretical roots, presents brief summaries of the four models presented at the Summit, compares the models for similarities and complementarities, and shares highlights from each of the presenters from the Summit.
Sonochemical synthesis of CeO2 nanoparticles with high photocatalytic and antibacterial activities under visible light
Authors: Zeng Shenghui , Shui Anze , Yu Hulei , He Chao 
Published: April 2024

AbstractCerium oxide (CeO2), one of the most significant heterogeneous catalysts, has attracted extensive research interest. Herein, ultrafine spherical CeO2 with a diameter of 5 nm is successfully synthesized within a reaction time of 25 min by a simple and environmentally friendly sonochemical method without any additional oxidants or high temperature and pressure conditions, and 50 nm spherical CeO2 was obtained by heat treating the 5 nm spherical CeO2 in 400°C air atmosphere condition for 3 h. By controlling the ultrasonic condition, a specific surface area of up to 194.2 m2/g and a bandgap as low as 2.2 eV are achieved in the CeO2 nanoparticles without any heat treatment. Further study has shown that the as‐prepared spherical CeO2 without heat treatment exhibits remarkable photocatalytic and antibacterial activities under visible light conditions. The study is beneficial for energy conservation in fabricating ultrafine photocatalytic and antibacterial nanomaterials.
An integrated analysis of the anticarcinogenic role of forkhead box protein 1 in oesophageal squamous cell carcinoma
Authors: Ye Guanzhi , Pan Gaojian , Zhu Xiaolei , Li Ning , Liu Hongming , Geng Guojun , Jiang Jie 
Published: April 2024

AbstractForkhead box protein 1 (FOXP1) serves as a tumour promoter or suppressor depending on different cancers, but its effect in oesophageal squamous cell carcinoma has not been fully elucidated. This study investigated the role of FOXP1 in oesophageal squamous cell carcinoma through bioinformatics analysis and experimental verification. We determined through public databases that FOXP1 expresses low in oesophageal squamous cell carcinoma compared with normal tissues, while high expression of FOXP1 indicates a better prognosis. We identified potential target genes regulated by FOXP1, and explored the potential biological processes and signalling pathways involved in FOXP1 in oesophageal squamous cell carcinoma through GO and KEGG enrichment, gene co‐expression analysis, and protein interaction network construction. We also analysed the correlation between FOXP1 and tumour immune infiltration levels. We further validated the inhibitory effect of FOXP1 on the proliferation of oesophageal squamous cell carcinoma cells through CCK‐8, colony formation and subcutaneous tumour formation assays. This study revealed the anticarcinogenic effect of FOXP1 in oesophageal squamous cell carcinoma, which may serve as a novel biological target for the treatment of tumour.
From Menace to Mundane: Moral Hazard and the Politics of the European Central Bank's Government Bond Purchases
Authors: Chang Michele , Howarth David , Pierret Laura 
Published: April 2024

AbstractDuring the Eurozone's sovereign debt crisis, the ideational consensus that shaped the foundation of Economic and Monetary Union (EMU) was destabilized by disagreement on unconventional monetary policies (UMPs), specifically government bond purchases. In the ECB's 2021 strategy review, however, UMPs were confirmed as standard elements of the European Central Bank's (ECB) toolbox. What happened? One argument frequently presented to question the legitimacy of UMPs is that they undermine the prior objective of the EMU of avoiding moral hazard. We analyse the politics of UMPs by focusing upon how top officials in four major Eurozone central banks have discursively constructed the relationship between the ECB's purchase of sovereign debt and moral hazard. We find that top central bank officials aligned to a large degree on the non‐necessary causal relationship between government bond purchases and moral hazard, which reinforced its legitimacy and eventual acceptance as ‘conventional’.
Risk factors for inadequate bowel preparation before colonoscopy: A meta‐analysis
Authors: Feng Lina , Guan Jialun , Dong Ruonan , Zhao Kai , Zhang Mingyu , Xia Suhong , Zhang Yu , Chen Liping , Xiao Fang , Liao Jiazhi 
Published: April 2024

AbstractObjectiveThis meta‐analysis aimed to comprehensively explore the risk factors for inadequate bowel preparation (IBP).MethodsWe searched the Embase, PubMed, Web of Science, and The Cochrane Library databases up to August 24, 2023, to identify observational studies and randomized controlled trials (RCTs) that examined risk factors for IBP. A random effects model was used to pool the adjusted odds ratios and 95% confidence intervals.ResultsA total of 125 studies (91 observational studies, 34 RCTs) were included. Meta‐analyses of observational studies revealed that three preparation‐related factors, namely, characteristics of last stool (solid or brown liquid), incomplete preparation intake, and incorrect diet restriction, were strong predictors of IBP. The other factors were moderately correlated with IBP incidence, including demographic variables (age, body mass index, male sex, Medicaid insurance, and current smoking), comorbidities (diabetes, liver cirrhosis, psychiatric disease, Parkinson's disease, previous IBP, poor mobility, inpatient, and Bristol stool form 1/2), medications (tricyclic antidepressants, opioids, antidepressants, narcotics, antipsychotics, and calcium channel blockers), and preparation‐related factors (preparation‐to‐colonoscopy interval not within 3 to 5/6 h, nonsplit preparation, and preparation instructions not followed). No colonoscopy indications were found to be related to IBP. Meta‐analyses of RCTs showed that education, constipation, stroke/dementia, and discomfort during preparation were also moderately associated with IBP. Most of the other findings were consistent with the pooled results of observational studies. However, primarily due to imprecision and inconsistency, the certainty of evidence for most factors was very low to moderate.ConclusionsWe summarized five categories of risk factors for IBP. Compared to demographic variables, comorbidities, medications, and colonoscopy indications, preparation‐related elements were more strongly associated with IBP. These findings may help clinicians identify high‐risk individuals and provide guidance for IBP prevention.
Valorization of waste seashells as bioadsorbent for sunflower oil bleaching
Authors: Seçilmiş Şakir Selçuk 
Published: April 2024

AbstractIn this study, the performance of waste seashells (SS) in adsorbing color and oxidation parameters during the bleaching process of sunflower oil was evaluated and compared with that of commercial clay. Seashell activation methods included microwave treatment (900 W for 30 min), acid treatment (7 N H2SO4), and a combination of both. Interestingly, the unactivated SS demonstrated superior adsorption performance compared with the activated SS. SS, which have the ability to eliminate color pigments like chlorophyll and carotenoid, were found to be effective in this regard. However, their effectiveness in reducing the peroxide and p‐anisidine value was not as successful as that of commercial clay. Free acidity content remained constant across all treatments. SS emerged as a cost‐effective alternative adsorbent, promising in preventing environmental pollution. Their use signifies a valuable contribution to sustainability. This study sheds light on SS potential as an eco‐friendly solution in industrial processes, warranting further exploration and application.Practical applicationsBiowaste valorization is a process that involves converting organic waste materials into valuable products, energy, or resources, instead of simply disposing of them in landfills or incinerating them. This approach has gained significance owing to its potential to address environmental, economic, and social challenges. In this respect, this study presents that bioadsorbent obtained from waste SS can be utilized for bleaching of sunflower oil.
Effects of pretreatments involving ohmic heating and infrared radiation on the drying process of bananas using hot air
Authors: Zare Amir Hossein , Azadbakht Mohsen , Naseri Reza 
Published: April 2024

AbstractNowadays, the hot air drying process is the most widely used method for producing dried food and agricultural products due to its suitable investment and low operational costs. However, one of the disadvantages of drying with hot air is the prolonged drying time, which sometimes leads to serious damage to the quality characteristics of the resulting products, especially at high temperatures. Therefore, there is a need to find the most suitable conditions for producing high‐quality dried products. To conduct this experiment, after determining the desired number of samples, infrared preheating and ohmic heating were performed sequentially. In the first stage of preheating, the samples were placed in the ohmic heating device, and in the second stage, they were exposed to infrared radiation. Then, the samples were transferred to a hot air dryer for complete drying. The results showed that the antioxidant content increased with the increase in the thickness of the banana slices. Moreover, an increase in the drying temperature and the number of infrared lamps led to a reduction in the antioxidant content. The slices with less thickness and higher drying temperatures had the minimum phenol content. The maximum and minimum measured values of the total phenol content were 34.51 and 37.32, respectively. The range of variation in the solid soluble content was between 11.708% and 19.5437% Brix. In addition, at the same temperature values, an increase in the thickness of the banana slices resulted in a decrease in the solid soluble content of the samples. Furthermore, with an increase in the temperature for slices of the same thickness, the solid soluble content of the samples increased.Practical applicationsThe purpose of this research is to evaluate the effect of the thickness factors of the sample pieces, the temperature of the hot air dryer along with ohmic heating pretreatments, and the infrared lamps in the hot air dryer on the quality indicators of banana.
Arabidopsis mRNA export factor MOS11: molecular interactions and role in abiotic stress responses
Authors: Rödel Amelie , Weig Ina , Tiedemann Sophie , Schwartz Uwe , Längst Gernot , Moehle Christoph , Grasser Marion , Grasser Klaus D. 
Published: April 2024

Summary

Transcription and export (TREX) is a multi‐subunit complex that links synthesis, processing and export of mRNAs. It interacts with the RNA helicase UAP56 and export factors such as MOS11 and ALYs to facilitate nucleocytosolic transport of mRNAs. Plant MOS11 is a conserved, but sparsely researched RNA‐binding export factor, related to yeast Tho1 and mammalian CIP29/SARNP.

Using biochemical approaches, the domains of Arabidopsis thaliana MOS11 required for interaction with UAP56 and RNA‐binding were identified. Further analyses revealed marked genetic interactions between MOS11 and ALY genes. Cell fractionation in combination with transcript profiling demonstrated that MOS11 is required for export of a subset of mRNAs that are shorter and more GC‐rich than MOS11‐independent transcripts.

The central α‐helical domain of MOS11 proved essential for physical interaction with UAP56 and for RNA‐binding. MOS11 is involved in the nucleocytosolic transport of mRNAs that are upregulated under stress conditions and accordingly mos11 mutant plants turned out to be sensitive to elevated NaCl concentrations and heat stress.

Collectively, our analyses identify functional interaction domains of MOS11. In addition, the results establish that mRNA export is critically involved in the plant response to stress conditions and that MOS11 plays a prominent role at this.
Ethnic votes and parties' mobilization: A case study of New Zealand
Authors: Zhao Luna L. 
Published: April 2024

AbstractThe aim of this research is to investigate how ethnicity and political parties' mobilization efforts influence the voting preferences of migrants in electoral contexts. To achieve this, an empirical study was conducted, focusing on New Zealand's two major parties (New Zealand National and New Zealand Labour Party) and their mobilization practice targeting ethnic Chinese voters. This research adopted a mixed‐methods approach, involving conducting interviews with Chinese community leaders and surveys within the community. The quantitative findings establish a positive correlation between a party's mobilization efforts and the level of support from Chinese ethnic voters. Furthermore, the research underscores the importance of genuine targeting, emphasizing the recognition and addressing of the unique needs and concerns of ethnic minority communities, rather than engaging in mere tokenism.Related ArticlesEscaleras, Monica, Dukhong Kim, and Kevin M. Wagner. 2019. “You Are Who You Think You Are: Linked Fate and Vote Choices among Latino Voters.” Politics & Policy 47(5): 902–30. https://doi.org/10.1111/polp.12329.McKay, Spencer. 2021. “The Politics of Referendum Rules: Evidence from New Zealand (1893–2016).” Politics & Policy 50(1): 137–53. https://doi.org/10.1111/polp.12445.Stokes‐Brown, Atiya Kai. 2009. “The Hidden Politics of Identity: Racial Self‐Identification and Latino Political Engagement.” Politics & Policy 37(6): 1281–305. https://doi.org/10.1111/j.1747‐1346.2009.00220.x.
Kant's mature account of monads as objects in the idea
Authors: Betti Pierpaolo 
Published: April 2024

AbstractIn On a Discovery, Kant depicts monads as simple beings that are thought in the idea as the ground of appearances. He argues that his account of monads is partially in line with both Leibniz's monadology and his own critical philosophy. However, in the Critique of Pure Reason, Kant appears to depart from the monadologies of his predecessors. In this article, I make sense of Kant's late subscription to a version of Leibniz's monadology by arguing that Kant considers monads to be the objects represented through cosmological and psychological ideas posited by reason in its search for the unconditioned conditions of appearances. In particular, I point to what I take to be two instances of what Kant calls “objects in the idea” in the Critique of Pure Reason, namely (a) the substratum of matter qua ground of external appearances, and (b) the soul qua ground of internal appearances. Drawing on Kant's reply to Eberhard and the Transcendental Dialectic of the first Critique, I highlight the merely regulative—and yet fundamental—role that monads conceived as objects of reason play in Kant's critical philosophy.