bluuebunny/crossref_metadata_2025_split huggingface dataset:
Safety of Transcatheter Patent Ductus Arteriosus Closure in Small Weight Infants
Authors: DRIGHIL ABDENASSER , AL JUFAN MANSOUR , AL OMRANE KHALID , AL ATTA JAMEEL , AL OMRANI AHMED , AL FADLEY FADEL 
Published: May 2012

Background:

Patent ductus arteriosus (PDA) is a frequent congenital heart disease. Its transcatheter closure has become the treatment of choice in children and adults. However, the device closure of PDA in children with low weight is still challenging with high rate of complications. The aim of this study was to report further experience with trancatheter closure of PDA using the Amplatzer Duct Occluder(ADO) for children weighing less or equal to 8 kg.
Methods:

Twenty‐two patients (5 male, 17 female) underwent transcatheter closure of a PDA using ADO at a median age of 10 months (range 4 to 26) and a median weight of 7 kg (range 4.3 to 8). Follow‐up evaluations were performed with Doppler echocardiography at 24h, and at 6 and 12 months.
Results:

The device was implanted successfully in all patients. The median fluoroscopy time was 17.25 min (range 10 to 29). Within 24h, color Doppler revealed complete closure in 15 patients (68%), the other patients had a small residual shunt. No deaths were associated with the procedure. Two patients had a slight aortic protrusion of the device without coarctation and in one patient the device encroached partially on the left pulmonary artery without significant acceleration on Doppler echocardiography. All patients were discharged home the next day. All patients completed the 6‐month follow‐up with complete closure in 18 patients (81%). At the last evaluation in all patients at any time, there has been documentation of complete PDA closure in 20 (91%) of 22 patients.
Conclusion:

In patients weighing less or equal to 8 kg, percutaneous closure of PDA using an ADO is a safe and effective procedure. (J Interven Cardiol 2012;25:391–394)
Patient‐specific phosphorus mobilization clearance during nocturnal and short daily hemodialysis
Authors: Agar Baris U. , Troidle Laura , Finkelstein Frederic O. , Kohn Orly F. , Akonur Alp , Leypoldt John K. 
Published: May 2012

AbstractThe kinetics of plasma phosphorus during different hemodialysis (HD) modalities are incompletely understood. We recently demonstrated that a pseudo one‐compartment kinetic model including phosphorus mobilization from various body compartments into extracellular fluids can describe intradialytic and postdialytic rebound kinetics of plasma phosphorus during conventional and short 2‐hour HD treatments. In this model, individual patient differences in phosphorus kinetics were characterized by a single parameter, the phosphorus mobilization clearance (KM). In this report we determined KM in patients treated by in‐center nocturnal HD (ICNHD) and short daily HD (SDHD) with low dialyzer phosphate clearance. In the ICNHD study, eight patients underwent 8‐hour HD treatments where intradialytic and postdialytic plasma samples were collected; KM values were determined by nonlinear regression of plasma concentration as a function of time. In the SDHD study, five patients were studied during 28 treatments for approximately 3 hours. Here, KM was calculated using only predialytic and postdialytic plasma phosphorus concentrations. Dialyzer phosphate clearances were 134 ± 20 (mean ± SD) and 95 ± 16 mL/min during ICNHD and SDHD, respectively. KM values for the respective therapies were 124 ± 83 and 103 ± 33 mL/min, comparable to those determined previously during conventional and short HD treatments of 98 ± 44 mL/min. When results from ICNHD, SDHD, and previous HD modalities were combined, KM was directly correlated with postdialytic body weight (r = 0.38, P = 0.025) and inversely correlated with predialytic phosphorus concentration (r = −0.47, P = 0.005). These findings suggest that phosphorus kinetics during various HD modalities can be described by a pseudo one‐compartment model.
What Difference Reveals About Similarity
Authors: Sagi Eyal , Gentner Dedre , Lovett Andrew 
Published: May 2012

AbstractDetecting that two images are different is faster for highly dissimilar images than for highly similar images. Paradoxically, we showed that the reverse occurs when people are asked to describe how two images differ—that is, to state a difference between two images. Following structure‐mapping theory, we propose that this disassociation arises from the multistage nature of the comparison process. Detecting that two images are different can be done in the initial (local‐matching) stage, but only for pairs with low overlap; thus, “different” responses are faster for low‐similarity than for high‐similarity pairs. In contrast, identifying a specific difference generally requires a full structural alignment of the two images, and this alignment process is faster for high‐similarity pairs. We described four experiments that demonstrate this dissociation and show that the results can be simulated using the Structure‐Mapping Engine. These results pose a significant challenge for nonstructural accounts of similarity comparison and suggest that structural alignment processes play a significant role in visual comparison.
Pulsation of the fetal splenic vein – a potential ultrasound marker of histological chorioamnionitis and funisitis in women with preterm prelabor rupture of membranes
Authors: MUSILOVA IVANA , KACEROVSKY MARIAN , HORNYCHOVA HELENA , KOSTAL MILAN , JACOBSSON BO 
Published: May 2012

AbstractThe fetal spleen is involved in the response to intrauterine infection and inflammation. The flow pattern of its vein is not pulsatile in normal conditions. The aim of the study was to determine whether the presence of histological chorioamnionitis and funisitis is associated with a continuous or pulsatile flow pattern in the fetal splenic vein. We performed a prospective study including 79 women with preterm prelabor rupture of membranes. We found a relation between pulsation in the splenic vein and histological chorioamnionitis (likelihood ratio 13.2), as well as funisitis (likelihood ratio 5.7). Ultrasound evaluation of the splenic vein could be a non‐invasive tool for the prediction of these inflammatory complications.
Balloon occlusion of the internal iliac arteries in the multidisciplinary management of placenta percreta
Authors: CLAUSEN CAROLINE , STENSBALLE JAKOB , ALBRECHTSEN CHARLOTTE K. , HANSEN MARC A. , LÖNN LARS , LANGHOFF‐ROOS JENS 
Published: May 2012

Abstract Objective. To evaluate our experience with prophylactic balloon occlusion of the internal iliac arteries as a part of a multidisciplinary algorithm for the management of placenta percreta. Design. Consecutive case series. Setting. Rigshospitalet, Copenhagen University Hospital, Denmark. Sample. Seventeen women with placenta percreta. Methods. Demographic characteristics, intraoperative data and outcomes are summarized and discussed. Main outcome measures. Feasibility of local resection, intraoperative blood loss and transfusion requirements. Results. The multidisciplinary management allowed for local resections in nine of the 11 women who requested preservation of fertility. The mean intraoperative blood loss was 4050 mL (range 450–16 000 mL, median 2500 mL). Adhesions to the bladder or the parietal peritoneum were associated with an intraoperative blood loss >6000 mL. Conclusions. Prophylactic balloon occlusion of the internal iliac arteries as part of a multidisciplinary algorithm allowed for a safe management of all cases in our consecutive series of 17 women with placenta percreta. However, intraoperative blood loss and transfusion requirements were significant. We have therefore decided to modify our multidisciplinary algorithm to include balloon occlusion of the common iliac arteries rather than the internal iliac arteries.
CD147 expression in advanced cutaneous squamous cell carcinoma
Authors: Sweeny Larissa , Dean Nichole R. , Frederick John W. , Scott Magnuson J. , Carroll William R. , Desmond Renee A. , Rosenthal Eben L. 
Published: May 2012

Background: CD147 is upregulated in multiple cancer types, but its expression in advanced cutaneous squamous cell carcinoma (SCC) is unknown. Our purpose was to evaluate the expression patterns of CD147 and related monocarboxylate transporters (MCT1, MCT4) to determine their correlation with survival.Methods: This is a retrospective cohort study of patients with advanced stage cutaneous SCC of the head and neck who presented to a tertiary care center between 1998 and 2006 (n=50). CD147, MCT1 and MCT4 expression levels were assessed using immunofluorescence analysis of archived tumor samples and correlated with survival and clinicopathologic characteristics.Results: The majority of patients (92%, n = 46) were diagnosed with stage III disease, with 46% (n = 23) having positive regional lymph node metastasis and 8% (n = 4) with distant metastasis. Primary malignancies had an overexpression of CD147 (78%; n = 35), MCT1 (23%; n = 10) and MCT4 (47%; n = 20). In addition, there was a significant relationship between the overexpression of CD147 and node positive disease (p = 0.048). Two‐ and five‐year survival rates were 69 and 61%, respectively. There was a trend toward decreased survival in patients with overexpression of CD147 (p = 0.17), MCT1 (p = 0.11) and MCT4 (p = 0.15).Conclusion: CD147 may represent a biomarker or potential therapeutic target in advanced cutaneous SCC.Sweeny L. Dean NR, Frederick JW, Scott Magnuson J, Carroll WR, Desmond RA, Rosenthal EL. CD147 expression in advanced cutaneous squamous cell carcinoma.
Consumption of the epidermis in acral lentiginous melanoma
Authors: Ohata Chika , Nakai Chiaki , Kasugai Tsutomu , Katayama Ichiro 
Published: May 2012

Background: Consumption of the epidermis (hereafter, consumption), namely thinning of the epidermis with attenuation of basal and suprabasal layers and loss of rete ridges adjacent to collections of melanocytes, has been used to differentiate invasive melanoma from Spitz nevi. Evaluation of 213 invasive melanomas, including only two cases of acral lentiginous melanoma (ALM), showed that the frequency of consumption increases with increasing tumor thickness.Methods: We evaluated consumption in 52 acral melanomas relative to age, gender, Breslow depth, tumor thickness (based on the 2010 American Joint Commission on Cancer guidelines), Clark level, mitoses, ulceration, vertical‐growth phase, regression, tumor‐infiltrating lymphocytes and anatomical site.Results: Consumption was more frequent in ALM with increasing Breslow depth (p = 0.01), and in the presence of ulceration (p = 0.0078); in all cases with ulcer, consumption was found adjacent to the ulceration. There was no statistically significant difference in consumption in nail melanomas in comparison to melanomas of acral skin other than the nail.Conclusions: These results support the hypothesis that epidermal thinning in consumption represents an early phase of ulceration. No statistically significant difference in consumption was found between nail melanomas and melanomas of acral skin other than the nail, probably because of similar tumor thickness in both groups.Ohata C, Nakai C, Kasugai T, Katayama I. Consumption of the epidermis in acral lentiginous melanoma.
The G60S Cx43 mutant enhances keratinocyte proliferation and differentiation
Authors: Churko Jared M. , Kelly John J. , MacDonald Andrew , Lee Jack , Sampson Jacinda , Bai Donglin , Laird Dale W. 
Published: May 2012

AbstractTransient knock‐down of the gap junction protein Cx43 by antisense and siRNA, or gap junction block with mimetic peptides, have been shown to enhance epidermal wound healing. However, patients with oculodentodigital dysplasia (ODDD) express mutant Cx43 that leads to a chronic reduction in gap junctional intercellular communication. To determine whether mutant Cx43 in keratinocytes would impact upon the wound healing process, we localized Cx43 in human and mouse skin tissue expressing mutant Cx43 and assessed the ability of primary keratinocytes derived from a mouse model of ODDD to proliferate, migrate and differentiate. In the epidermis from an ODDD patient and in the epidermis of mice expressing the G60S mutant or in keratinocytes obtained from mutant mice, Cx43 was frequently found within intracellular compartments and rarely localized to punctate sites of cell–cell apposition. Primary keratinocytes derived from G60S mutant mice proliferated faster but migrated similarly to keratinocytes derived from wild‐type control mice. Keratinocytes derived from mutant mice expressed abundant Cx43 and higher levels of involucrin and loricrin under low calcium conditions. However, after calcium‐induced differentiation, similar levels of Cx43, involucrin and loricrin were observed. Thus, we conclude that during wound healing, mutant Cx43 may enhance keratinocyte proliferation and promote early differentiation of keratinocytes.
Phagosome as the Organelle Linking Innate and Adaptive Immunity
Authors: Kagan Jonathan C. , Iwasaki Akiko 
Published: May 2012

AbstractThe means by which phagocytosis and antimicrobial defense mechanisms are linked have expanded greatly in recent years. It is now clear that the process of phagocytosis does more than just degrade internalized microbes, but also helps coordinate the actions of the innate and adaptive immune system. This review will discuss the means by which Toll‐like receptor signaling pathways are coordinated around the processes of phagocytosis, phagosome trafficking and autophagy and how these signaling pathways influence T‐cell‐mediated immunity. In this regard, we propose that at the subcellular level, phagosomes represent the smallest definable unit that links innate and adaptive immunity.
Evaluation of energetic metabolism in the rat brain after meningitis induction byKlebsiella pneumoniae
Authors: Barichello Tatiana , Simões Lutiana Roque , Generoso Jaqueline S. , Carradore Mirelle M. , Moreira Ana Paula , Panatto Ana Paula , Costa Caroline S. , Filho Álvaro Steckert , Jeremias Isabela C. , Bez Gisele D. , Streck Emilio 
Published: May 2012

BackgroundBacterial meningitis is an infection of the central nervous system characterised by strong inflammatory response. The brain is highly dependent on ATP, and the cell energy is obtained through oxidative phosphorylation, a process which requires the action of various respiratory enzyme complexes and creatine kinase (CK) as an effective buffering system of cellular ATP levels in tissues that consume high energy.ObjectivesEvaluate the activities of mitochondrial respiratory chain complexes I, II, III, IV and CK activity in hippocampus and cortex of the Wistar rat submitted to meningitis byKlebsiella pneumoniae.MethodsAdult Wistar rats received either 10 µl of sterile saline as a placebo or an equivalent volume ofK. pneumoniaesuspension. The animals were killed in different times at 6, 12, 24 and 48 h after meningitis induction. Another group was treated with antibiotic, starting at 16 h and continuing daily until their decapitation at 24 and 48 h after induction.ResultsIn the hippocampus, the meningitis group without antibiotic treatment, the complex I was increased at 24 and 48 h, complex II was increased at 48 h, complex III was inhibited at 6, 12, 24 and 48 h and in complex IV all groups with or without antibiotic treatment were inhibited after meningitis induction, in the cortex there was no alteration.DiscussionAlthough descriptive, our results show that antibiotic prevented in part the changes of the mitochondrial respiratory chain. The meningitis model could be a good research tool to study the biological mechanisms involved in the pathophysiology of theK. pneumoniaemeningitis.
Efficacy and safety of rituximab in pemphigus: experience of the German Registry of Autoimmune Diseases
Authors: Kasperkiewicz Michael , Eming Rüdiger , Behzad Melika , Hunzelmann Nicolas , Meurer Michael , Schulze‐Koops Hendrik , von Wussow Peter , Hertl Michael , Zillikens Detlef , Freivogel Klaus , Dörner Thomas , Schmidt Enno 
Published: May 2012

SummaryBackground: Rituximab has been reported to be effective in various small case series of patients with severe and/or refractory pemphigus. However, no systematic evaluation is available to corroborate this observation. The aim of this study was to systematically determine efficacy and safety of rituximab in treatment‐resistant pemphigus.Patients and Methods: Multicenter retrospective, observational study of 36 patients with severe pemphigus vulgaris (n = 33) and pemphigus foliaceus (n = 3) treated with rituximab before August 31st, 2008 and enrolled in a national observational registery between December 2008 and June 2009.Results: Within a mean period of observation of 11 (1–37) months, 21 (58 %) pemphigus patients showed complete, 13 (36 %) partial, and 2 (6 %) no response to rituximab treatment. This correlates with a mean improvement of the visual analog scale for well‐being of 34 (20–60) at baseline to 75 (40–95) at the last control visit. In 4 (11 %) patients, severe adverse events were recorded including 1 (3 %) serious infection.Conclusions: Data collected in this systematic registry indicate that rituximab is an effective and relatively safe adjuvant treatment option for refractory pemphigus. To further extend our knowledge on efficacy and safety of this drug, controlled prospective trials are required.
Impact of Platform Switching on Peri‐Implant Bone Remodeling around Short Implants in the Posterior Region, 1‐Year Results from a Split‐Mouth Clinical Trial
Authors: Telleman Gerdien , Raghoebar Gerry M. , Vissink Arjan , Meijer Henny J.A. 
Published: May 2012

ABSTRACTAim: To assess the effect of platform switching on peri‐implant bone remodeling around short implants (8.5 mm) placed in the resorbed posterior mandibular and maxillary region of partially edentulous patients.Materials and Methods: Seventeen patients with one or more missing teeth at both sides in the posterior region were, according to a split‐mouth design, randomly assigned to be treated with a platform‐matched (control) implant on the one side and a platform‐switched implant (test) on the other side. A total of 62 short implants (8.5 mm) with a dual‐acid etched surface with nanometer‐sized calcium phosphate particles was placed. Follow‐up visits were conducted one month and one year after placing the implant crown. Outcome measures were interproximal bone level changes, implant survival and clinical parameters.Results: One year after loading, peri‐implant bone remodeling around test implants (0.53 ± 0.54 mm) was significant less than around control implants (0.85 ± 0.65 mm; p = .003). With regard to implant survival and clinical parameters no significant differences were observed between test and control implants.Conclusions: This study suggested that peri‐implant bone remodeling is affected by platform switching. One year after loading, interproximal bone levels were better maintained at implants restored according to the platform switching concept.
Occult Hepatitis B Virus Infection in Hemodialysis Patients: A Concept for Consideration
Authors: Aghakhani Arezoo , Banifazl Mohammad , Velayati Ali Akbar , Eslamifar Ali , Ramezani Amitis 
Published: May 2012

AbstractHemodialysis patients potentially have an increased risk of infection with parenterally transmitted viral agents due to an impaired host immune response and multiple transfusion requirements. Viral hepatitis is considered as a problem for hemodialysis patients because 1.9% of all deaths among this population are related to the consequence of viral hepatitis. Hepatitis B virus (HBV) is one of the most important causes of transmitted infections by the parenteral route in hemodialysis patients. Occult HBV infection is characterized by presence of HBV infection without detectable hepatitis B surface antigen (HBsAg), which harbors potential risk of HBV transmission through hemodialysis. There are conflicting reports on the prevalence of occult HBV infection (OBI) in hemodialysis patients. Considering the importance of occult HBV infection in hemodialysis patients and the growing evidence on this subject, the purpose of this review is to provide comprehensive information on OBI prevalence in hemodialysis patients and highlight the most important points in this issue.
The effect of acupuncture on ovulatory frequency and pituitary gonadotropin hormones in women with polycystic ovarian syndrome
Authors: Li D , Pastore LM 
Published: May 2012

Pastore LM, Williams CD, Jenkins J, Patrie JT.True and sham acupuncture produced similar frequency of ovulation and improved LH to FSH ratios in women with polycystic ovary syndrome.Endocr Res 2011; 96: 3143–50.
No effect of acupuncture for depression – time to perform a large head‐to‐head trial?
Authors: Stener‐Victorin E 
Published: May 2012

Andreescu C, Glick RM, Emeremni CA, Houck PR Mulsant BH.Acupuncture for the treatment of major depressive disorder: a randomized controlled trial.J Clin Psychiatry 2011; 72: 1129–35.
Impact of a herbal mixture on sinonasal olfactory dysfunction
Authors: Chrubasik S , Reden J , Hummel T 
Published: May 2012

Reden J, El‐Hifnawi DJ, Zahnert T, Hummel T.The effect of a herbal combination of primrose, gentian root, vervain, elder flowers, and sorrel on olfactory function in patients with a sinonasal olfactory dysfunction.Rhinology 2011; 49: 342–6.
A Chinese formula for relief of Parkinson's disease symptoms used concomitantly with levodopa
Authors: Roufogalis BD , Min L 
Published: May 2012

Kum WF, Durairajan SS, Bian ZX, Man SC, Lam YC, Xie LX, Lu JH, Wang Y, Huang XZ, Li M.Treatment of idiopathic Parkinson's disease with traditional Chinese herbal medicine: a randomized placebo‐controlled pilot clinical study.Evid Based Complement Alternat Med 2011: 724353.