bluuebunny/crossref_metadata_2025_split huggingface dataset:
The effect of deep venous thrombosis on short‐term outcomes and cost of care after head and neck cancer surgery
Authors: Hennessey Patrick , Semenov Yevgeniy R. , Gourin Christine G. 
Published: August 2012

AbstractObjectives/Hypothesis:The Centers for Medicare and Medicaid Services has targeted deep venous thrombosis (DVT) and pulmonary embolus (PE) as preventable “never events” and has discontinued reimbursement for these conditions following selected orthopedic procedures. We sought to determine the relationship between DVT/PE and in‐hospital mortality, postoperative complications, length of stay, and costs in head and neck cancer (HNCA) surgery.Study Design:Retrospective cross‐sectional study.Methods:Discharge data from the Nationwide Inpatient Sample for 93,663 patients who underwent an ablative procedure for a malignant oral cavity, laryngeal, hypopharyngeal, or oropharyngeal neoplasm in 2003 to 2008 were analyzed using cross‐tabulations and multivariate regression modeling.Results:DVT/PE was diagnosed in 1,860 cases (2%) and was significantly associated with major surgical procedures (odds ratio [OR], 1.4; P = .048) and advanced comorbidity (OR, 1.7; P = .034). After controlling for all other variables, no association was found between a diagnosis of DVT/PE and obesity, weight loss, age, chronic cardiac disease, paralysis, and smoking in this HNCA surgical population. DVT/PE was associated with increased risk of in‐hospital mortality (OR, 3.1; P = .001), postoperative surgical complications (OR, 2.1; P < .001), acute medical complications (OR, 1.9; P < .001), and was associated with significantly increased length of hospitalization and hospital‐related costs.Conclusions:DVT/PE is uncommon in HNCA patients but is associated with increased mortality, postoperative complications, length of hospitalization, and hospital‐related costs. The lack of correlation with known modifiable variables suggests that despite advances in targeted prophylaxis, patients with advanced disease and comorbidity remain at increased risk. Caution must be used in the institution of reforms that threaten to inadequately reimburse the provision of care in vulnerable populations. Laryngoscope, 2012
Modification and testing of a pneumatic dispensing device for controlled delivery of injectable materials
Authors: Heaton James T. , Kobler James B. , Ottensmeyer Mark P. , Lopez‐Guerra Gerardo , Karajanagi Sandeep S. , Burns James A. , Zeitels Steven M. 
Published: August 2012

AbstractObjectives/Hypothesis:Vocal fold (VF) injections of viscous materials are typically performed using hand‐operated syringes or injection guns; however, these methods can be imprecise due to accumulation of pressure, effort‐related tremor, and poor feedback regarding injection volume and rate.Study Design:Apparatus development with laboratory bench‐top and animal model testing.Methods:A foot pedal‐triggered device for dispensing viscous materials was modified by adding a linear transducer and display for monitoring dispensed volume. In bench tests, bovine VFs were injected with fluids/materials of different viscosities (saline, glycerol, hydrogel, and liposuctioned fat) through narrow‐bore needles using a range of driving pressures and air pulse durations. The device was further evaluated in >50 in vivo VF injection experiments.Results:Device function was repeatable, with high correlations (typically R2 > 0.98) between the readout and direct measures of volume, even for small volumes (<5 μL/pulse). Foot pedal control enabled surgeons to make steady, accurate injections into ferret and dog VFs during phonosurgery, and, because the dispenser released all driving pressure between pulses, there were no instances of clog‐related overinjection when the obstruction cleared.Conclusions:This VF injection system shows promise for development to enhance human phonosurgery by increasing injection control and precision. Laryngoscope, 2012
Efficacy of the pillar implant in the treatment of snoring and mild‐to‐moderate obstructive sleep apnea: A meta‐analysis
Authors: Choi Ji Ho , Kim Soo‐Nyung , Cho Jae Hoon 
Published: August 2012

AbstractObjectives/Hypothesis:The Pillar implant is one of the surgical options for snoring and obstructive sleep apnea (OSA). It is designed to be inserted into the soft palate to reduce vibration and collapsibility. The efficacy of the Pillar implant has been evaluated in various studies. However, only one study conducted a meta‐analysis of the findings, and was based on only three studies. We tried to get a more definite conclusion on the efficacy of the Pillar implant.Study Design:Meta‐analysis.Methods:Efficacies were analyzed separately, one for snoring and the other for mild‐to‐moderate OSA. We searched MEDLINE, LILACS, SCOPUS, and the Cochrane Library. The key words “snoring AND implants” were used for snoring, and “apnea AND implants” for OSA. Seven studies for snoring and seven studies for mild‐to‐moderate OSA were finally included for meta‐analysis. For snoring patients, a visual analogue scale that is scored by the bed partner was used to evaluate the loudness of the snoring sound.Results:The Pillar implant reduced snoring sound significantly (standardized mean difference [SMD], −0.591; 95% confidence interval [CI], −0.753 to −0.429, P < .001). For mild‐to‐moderate OSA patients, the Pillar implant significantly reduced the Epworth Sleepiness Scale (SMD, −0.481; 95% CI, −0.606 to −0.358, P < .001), and apnea‐hypopnea index (SMD, −0.378; 95% CI, −0.619 to −0.138, P = .002). Mean extrusion rate was 9.3% (95% CI, 7.0 to 12.2%).Conclusions:The present results indicate that the Pillar implant has a moderate effect on snoring and mild‐to‐moderate OSA. However, we need more studies with high level of evidence to arrive at a definite conclusion. Laryngoscope, 2013
Long‐term effects of injection laryngoplasty with a temporary agent on voice quality and vocal fold position
Authors: Prendes Brandon L. , Yung Katherine C. , Likhterov Ilya , Schneider Sarah L. , Al‐Jurf Soha A. , Courey Mark S. 
Published: August 2012

AbstractObjectives/Hypothesis:Patients with unilateral vocal fold paralysis (UVFP) treated with temporary injection laryngoplasty (IL) have a decreased rate of permanent medialization laryngoplasty (ML) compared to UVFP patients initially treated by observation. The aim of this study was to determine whether the lower rate of ML corresponded with improved quantifiable measures.Study Design:Retrospective review.Methods:Examinations at presentation and follow‐up of 14 IL patients and 24 observation patients were analyzed for laryngoscopic features and Consensus Auditory‐Perceptual Evaluation of Voice (CAPE‐V) scores.Results:The groups were similar at presentation. At follow‐up, the IL group showed significant improvement in 11/18 laryngoscopic criteria and 7/12 CAPE‐V parameters compared to the observation group (P < .05). The observation group underwent ML more frequently than the IL group (75% vs. 29%, P = .008).Conclusions:The lower rate of permanent ML in patients undergoing temporary IL corresponds with improvements in CAPE‐V scores and laryngoscopic features. Improvements persisted beyond the accepted time frame for temporary graft resorption. Laryngoscope, 2012
Endoscopic sandwich technique for moderate nasal septal perforations
Authors: Chen Feng‐Hong , Rui Xu , Deng Jie , Wen Yi‐Hui , Xu Geng , Shi Jian‐Bo 
Published: August 2012

AbstractObjectives/Hypothesis:The aim of this article was to describe our surgical technique for the treatment of nasal septal perforations with diameters of 1 to 2 cm.Study Design:Retrospective clinical research.Methods:We reviewed 13 patients with moderate nasal septal perforations (1–2 cm diameter) treated with a sandwich technique (bone or cartilage and quadriceps fascia graft as an interposition graft) by an endoscope‐assisted intranasal approach from January 2008 to June 2011. Follow‐up periods were 3 months.Results:Thirteen patients were treated with the sandwich technique. Twelve cases (92.3%) were completely healed. One case received incomplete closures without any postoperative symptoms. All patients were found not to have any complications after surgery.Conclusions:The transnasal endoscopic sandwich technique for repairing moderate nasal septal perforation (1–2 cm) has a high success rate and is easy to perform. Laryngoscope, 2012
Preoperative topical antimicrobial decolonization in head and neck surgery
Authors: Shuman Andrew G. , Shuman Emily K. , Hauff Samantha J. , Fernandes Laura L. , Light Emily , Chenoweth Carol E. , Bradford Carol R. 
Published: August 2012

AbstractObjectives/Hypothesis:Surgical site infections (SSIs) are an important cause of morbidity and mortality after head and neck surgery. Our primary objective was to determine the efficacy of preoperative topical antimicrobial decolonization before head and neck surgery.Study Design:Prospective, randomized controlled trial.Methods:This study was conducted among 84 patients presenting for head and neck surgery requiring admission to an academic medical center. Preoperative cultures were performed to identify Staphylococcus aureus carriers. Patients were randomized to preoperative topical antimicrobial decolonization with a 5‐day regimen of chlorhexidine skin rinses and intranasal mupirocin coupled with standard perioperative systemic antimicrobial prophylaxis, versus standard prophylaxis alone. The main outcome was the incidence of SSIs.Results:Despite a trend suggesting a decrease in SSIs with perioperative topical antimicrobial decolonization (24% vs. 10%), there was no significant difference (odds ratio, 0.34; 95% confidence interval, 0.10–1.18; P = .079). Patients with a higher American Society of Anesthesiologists score (3 vs. 1; P = .02), with more operative blood loss (P = .05), and who required operative takeback (P = .04) had a higher rate of SSIs; there was a trend suggesting a higher rate of SSIs among patients undergoing clean‐contaminated surgery compared to clean cases (P = .08) and among those having received prior radiation (P = .07) or chemotherapy (P = .06).Conclusions:Preoperative antimicrobial decolonization did not significantly decrease the incidence of SSIs after head and neck surgery, but might be considered for high‐risk groups despite the lack of conclusive evidence confirming efficacy. Risk factors for SSIs after head and neck surgery are identified for the first time in a prospective study. Laryngoscope, 2012
Evaluation of adult pott's puffy tumor: Our five cases and 27 literature cases
Authors: Akiyama Kosuke , Karaki Masayuki , Mori Nozomu 
Published: August 2012

AbstractObjectives/Hypothesis:Pott's puffy tumor (PPT) is defined as one or more subperiosteal abscesses of the frontal bone based on osteomyelitis. PPT is observed predominantly in the adolescent age group and rarely in adults. Some parameters affecting prognosis and an appropriate surgical approach for antecedent frontal sinusitis have not been elucidated due to the rarity of patients with adult PPT.Study Design:Retrospective patient record and literature study.Methods:Five patients from our cohort and 27 patients identified in a literature search formed the study group.Results:The incidence rate of intracranial complications was lower than in previous reports at 29.0%. There was no correlation between the incidence rate of intracranial complications and each patient's parameters. It was indicated that the department first consulted by the patients was possibly related to the initial diagnosis and the incidence rate of intracranial complications.Conclusions:Although the incidence rate of major complications is lower than in children and later than in earlier published adult cases, patients are still at high risk of serious intracranial complications. Early diagnosis and adequate treatment may contribute to reducing the incidence rate. Laryngoscope, 2012
Hunsaker mon‐jet tube ventilation: A 15‐year experience
Authors: Hu Amanda , Weissbrod Philip A. , Maronian Nicole C. , Hsia Jennifer , Davies Joanna M. , Sivarajan Gouri K. , Hillel Allen D. 
Published: August 2012

AbstractObjective/Hypothesis:The Hunsaker Mon‐Jet tube (HMJT) (Xomed, Jacksonville, FL) has been used effectively for subglottic ventilation. We previously reported a series of 552 patients over a 10‐year period with no major complications. This is a continuation of that series with an additional 5 years of cases.Study Design:Retrospective consecutive case series.Methods:Patients who were ventilated with the HMJT for microlaryngeal surgery at the University of Washington Medical Center over a 15‐year period (1995–2010) were identified from the Voice Disorders database. Charts were reviewed for demographic data, laryngeal diagnosis, and anesthetic parameters. Main outcome measure was the rate of complications.Results:Fifty‐seven complications occurred in 49 cases out of 839 cases (5.8% complication rate). In descending order, the complications were hypoxia (SpO2 <90%, n = 30, 3.6%), hypercarbia (end tidal CO2 of >60 mm Hg, n = 17, 2.0%), airway obstruction (n = 4, 0.5%), barotrauma (n = 2, 0.2%), seeding of blood into trachea (n = 2, 0.2%), submucosal injection of air (n = 1, 0.1%), and mucosal damage (n = 1, 0.1%). Factors associated with complications included high body mass index (P = .04), American Society of Anesthesiology class III or IV (P = .01), history of heart disease (P = .02), history of previous laryngeal surgery (P = .02), longer duration of case (P = .006), and laser use (P = .005).Conclusions:Although subglottic ventilation via an HMJT is a safe alternative to traditional endotracheal intubation in an appropriately selected population, practitioners should remain vigilant about the known complications. Laryngoscope, 2012
Ossicular fusion and cholesteatoma in auriculo‐condylar syndrome: In vivo evidence of arrest of embryogenesis
Authors: Propst Evan J. , Ngan Bo Y. , Mount Richard J. , Martin‐Munoz Daniel , Blaser Susan , Harrison Robert V. , Cushing Sharon L. , Papsin Blake C. 
Published: August 2012

AbstractAuriculo‐condylar syndrome (ACS) is a rare condition affecting first branchial arch structures. The types of hearing loss and temporal bone findings in ACS have not been reported. We describe a 14‐year‐old male with constricted pinnae, mandibular dysostosis, glossoptosis, a high‐arched palate, hearing loss, and cholesteatoma. Computed tomography imaging demonstrated malleoincudal joint ankylosis. The fused malleoincudal complex was removed during mastoidectomy for cholesteatoma. Electron microscopy and histopathology of the joint suggested the fusion was congenital. This is the first report of ossicular fusion and cholesteatoma in ACS and the most detailed in vivo evidence of disruption of embryogenesis during malleoincudal joint formation. Laryngoscope, 2012
How long is long enough to follow up children after cholesteatoma surgery? A 29‐year study
Authors: Kuo Chin‐Lung , Shiao An‐Suey , Liao Wen‐Huei , Ho Ching‐Yin , Lien Chiang‐Feng 
Published: August 2012

AbstractObjectives/Hypothesis:To identify an association between follow‐up period and cholesteatoma recidivism.Study Design:Retrospective review.Methods:From 1982 to 2011, we retrospectively screened a consecutive series of children (≤18 years) with acquired cholesteatomas after primary surgery. The cumulative recidivism rates were calculated using standard calculation methods and Kaplan‐Meier survival analysis.Results:A total of 73 operations were performed on 71 patients. The mean age was 10.7 years, and the mean follow‐up period was 15.4 years. The number of censored cases increased with the follow‐up time. Sixty‐four (88%) operations had a follow‐up period of 5 years or longer, and 41 (56%) operations 15 years or longer. Cholesteatoma recidivism was observed in seven ears (five recurrent and two residual diseases). The mean detection time was 10.4 years (range 1.9–17.2 years). Five of the seven ears (71.4%) with recidivism were detected more than 10 years after surgery. The recidivism rate increased with the follow‐up time. However, the rates at 5, 10, 15, 20, and 25 years as calculated by the standard calculation method (1.4%, 2.7%, 8.2%, 9.5% and 9.5%, respectively) were underestimated compared with that by Kaplan‐Meier analysis (1.4%, 3.1%, 11.6%, 14.4% and 14.4%, respectively).Conclusions:The Kaplan‐Meier survival analysis method should be used when discussing recidivism rates, because the number of censored cases inevitably increases with observation time. Due to the late occurrence of recidivism and because the recidivism rate increases as time goes on, children should be periodically followed up for as long as possible. Laryngoscope, 2012
Congruences and ideals on Peirce algebras: a heterogeneous/homogeneous point of view
Authors: Pinto Sandra Marques , Oliveira‐Martins M. Teresa 
Published: August 2012

AbstractFor a Peirce algebra \documentclass{article}\usepackage{amssymb}\begin{document}\pagestyle{empty}${\mathcal P}$\end{document}, lattices \documentclass{article}\usepackage{amssymb}\begin{document}\pagestyle{empty}$\mathrm{Cong}\mathcal {P}$\end{document} of all heterogenous Peirce congruences and \documentclass{article}\usepackage{amssymb}\begin{document}\pagestyle{empty}$\mathrm{Ide}\mathcal {P}$\end{document} of all heterogenous Peirce ideals are presented. The notions of kernel of a Peirce congruence and the congruence induced by a Peirce ideal are introduced to describe an isomorphism between \documentclass{article}\usepackage{amssymb}\begin{document}\pagestyle{empty}$\mathrm{Cong}\mathcal {P}$\end{document} and \documentclass{article}\usepackage{amssymb}\begin{document}\pagestyle{empty}$\mathrm{Ide}\mathcal {P}$\end{document}. This isomorphism leads us to conclude that the class of the Peirce algebras is ideal determined. Opposed to Boolean modules case, each part of a Peirce ideal I = (I1, I2) determines the other one. A similar result is valid to Peirce congruences. A characterization of the simple Peirce algebras is presented coinciding to that given by Brink, Britz and Schmidt in a homogeneous approach.
On the constructive notion of closure maps
Authors: Ardeshir Mohammad , Ramezanian Rasoul 
Published: August 2012

AbstractLet A be a subset of the constructive real line. What are the necessary and sufficient conditions for the set A such that A is continuously separated from other reals, i.e., there exists a continuous function f with f−1(0) = A? In this paper, we study the notions of closed sets and closure maps in constructive reverse mathematics.
On proofs of the incompleteness theorems based on Berry's paradox by Vopěnka, Chaitin, and Boolos
Authors: Kikuchi Makoto , Kurahashi Taishi , Sakai Hiroshi 
Published: August 2012

AbstractBy formalizing Berry's paradox, Vopěnka, Chaitin, Boolos and others proved the incompleteness theorems without using the diagonal argument. In this paper, we shall examine these proofs closely and show their relationships. Firstly, we shall show that we can use the diagonal argument for proofs of the incompleteness theorems based on Berry's paradox. Then, we shall show that an extension of Boolos' proof can be considered as a special case of Chaitin's proof by defining a suitable Kolmogorov complexity. We shall show also that Vopěnka's proof can be reformulated in arithmetic by using the arithmetized completeness theorem.
Impact of Filler Functionalisation on the Crystallinity, Thermal Stability and Mechanical Properties of Thermoplastic Elastomer/Carbon Nanotube Nanocomposites
Authors: Prado Luís Antônio Sanchez de Almeida , Kopyniecka Agata , Chandrasekaran Swetha , Broza Georg , Roslaniec Zbigniew , Schulte Karl 
Published: August 2012

AbstractIn the present work, the functionalisation of oxidised SWCNTs and MWCNTs is studied. The functionalised fillers are characterised by Raman spectroscopy and TGA. The functionalised fillers are dispersed in a PBT‐PTMO thermoplastic elastomer matrix via in situ polymerisation. The functionalisation causes a fine filler dispersion right at beginning of nanocomposite manufacturing. The fillers act as nucleating agents for crystallisation and evidences for a grafting from PBT at the surface of the functionalised nanotubes are found. An outstanding reinforcement effect by the functionalised CNTs is confirmed by tensile tests. magnified image
Poly(2‐oxazoline)s as Polymer Therapeutics
Authors: Luxenhofer Robert , Han Yingchao , Schulz Anita , Tong Jing , He Zhijian , Kabanov Alexander V. , Jordan Rainer 
Published: August 2012

AbstractPoly(2‐oxazoline)s (POx) are currently discussed as an upcoming polymer platform for biomaterials design and especially for polymer therapeutics. POx meet specific requirements needed for the development of next‐generation polymer therapeutics such as biocompatibility, high modulation of solubility, variation of size, architecture as well as chemical functionality. Although in the early 1990s first and promising POx‐based systems were presented, the field lay dormant for almost two decades. Only very recently, POx‐based polymer therapeutics came back into the focus of very intensive research. In this review, we give an overview on the chemistry and physicochemical properties of POx and summarize the research of POx–protein conjugates, POx–drug conjugates, POx‐based polyplexes and POx micelles for drug delivery.
Rad59 regulates association of Rad52 with DNA double‐strand breaks
Authors: Pannunzio Nicholas R. , Manthey Glenn M. , Liddell Lauren C. , Fu Becky Xu Hua , Roberts Cai M. , Bailis Adam M. 
Published: August 2012

AbstractHomologous recombination among repetitive sequences is an important mode of DNA repair in eukaryotes following acute radiation exposure. We have developed an assay in Saccharomyces cerevisiae that models how multiple DNA double‐strand breaks form chromosomal translocations by a nonconservative homologous recombination mechanism, single‐strand annealing, and identified the Rad52 paralog, Rad59, as an important factor. We show through genetic and molecular analyses that Rad59 possesses distinct Rad52‐dependent and ‐independent functions, and that Rad59 plays a critical role in the localization of Rad52 to double‐strand breaks. Our analysis further suggests that Rad52 and Rad59 act in multiple, sequential processes that determine genome structure following acute exposure to DNA damaging agents.
Clinicopathological study in progressive supranuclear palsy with pedunculopontine stimulation
Authors: Hazrati Lili‐Naz , Wong Janice C. , Hamani Clement , Lozano Andres M. , Poon Yu‐Yan , Dostrovsky Jonathan O. , Hutchison William D. , Zadikoff Cindy , Moro Elena 
Published: August 2012

AbstractBackground:Pedunculopontine nucleus (PPN) DBS has emerged as a potential intervention for patients with gait and balance disorders. However, targeting this nucleus can be challenging. We report on the first neuropathological analyses after PPN‐DBS surgery in advanced progressive supranuclear palsy (PSP).Methods:Two patients with PSP underwent unilateral PPN‐DBS surgery and were clinically followed to autopsy. Both patients underwent postmortem neuropathological analysis, including choline acetyltransferase immunohistochemistry, to ascertain PPN boundaries and electrode location.Results:Both patients experienced partial improvement in some motor and nonmotor domains postintervention, but died shortly of other complications. Postmortem neuropathological analysis of each patient confirmed the electrode in a region of cholinergic neuronal loss corresponding to the PPN.Conclusions:We provide histopathological evidence for the validity of our stereotactic approach to target the PPN and correlate electrode location with clinical outcomes. © 2012 Movement Disorder Society