bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of extraction method on quality of orange juice: hand‐squeezed, commercial‐fresh squeezed and processed
Authors: Baldwin Elizabeth A , Bai Jinhe , Plotto Anne , Cameron Randall , Luzio Gary , Narciso Jan , Manthey John , Widmer Wilbur , Ford Bryan L 
Published: January 2012

AbstractBACKGROUND: Fresh orange juice is perceived to be more wholesome than processed juice. Fresh juice may have flavor and nutrients that differ from pasteurized or processed juice.RESULTS: ‘Hamlin’ and ‘Valencia’ oranges were extracted using a commercial food service juicer, pasteurized or not, resulting in fresh‐commercial juice (FCJ) or pasteurized juice (FCPJ) for comparison with pasteurized processed juice (PPJ) in 2009, and gently hand‐squeezed ‘Valencia’ juice (HSJ) in 2010 for quality attributes. There was higher peel oil, lower pectin content, and less cloud loss in FCJ/FCPJ compared to PPJ and HSJ regardless of pasteurization. Titratable acidity was generally higher and the ratio of solids to acids lower in FCJ/FCPJ or HSJ compared to PPJ. FCJ/FCPJ had generally higher levels of most aroma volatiles than did PPJ and, overall, the highest esters and terpenes, while methanol and ethanol levels were highest in HSJ. For sensory evaluation, FCJ/FCPJ had more peel oil and PPJ more cooked flavor than other samples, while ‘Valencia’ HSJ was preferred over the other juices.CONCLUSION: High peel oil content and thermo‐pasteurization process decreased cloud loss of orange juice. Extraction and finishing processes rather than pasteurization or oil content were major factors in influencing orange juice flavor quality. Copyright © 2012 Society of Chemical Industry
Morphology Tailoring of Thin Film Block Copolymers on Patterned Substrates
Authors: Ye Xianggui , Edwards Brian J. , Khomami Bamin 
Published: January 2012

AbstractIt is well known that chemically patterned substrates can direct the assembly of adsorbed layers or thin films of block copolymers. For a cylinder‐forming diblock copolymer on periodically spot‐patterned substrates, the morphology of the block copolymer follows the pattern at the substrate; however, with different periodic spacing and spot size of the pattern, novel morphologies can be created. Specifically, we have demonstrated that new morphologies that are absent in the bulk system can be tailored by judiciously varying the mismatch between the width of the pattern and the periodic spacing of the bulk block copolymer, the top surface affinity, and spot size. New morphologies can thus be achieved, such as honeycomb and ring structures, which do not appear in the bulk system. These results demonstrate a promising strategy for fabrication of new nanostructures from chemically patterned substrates.
Vaccine discontinuation and switching following regulatory interventions in response to rotavirus vaccine contamination with porcine circovirus DNA fragments
Authors: Dore David D. , Turnbull Bruce R. , Seeger John D. 
Published: January 2012

ABSTRACTPurposeThe Food and Drug Administration temporarily suspended monovalent rotavirus vaccine (RV1) use following discovery of contamination with porcine circovirus fragments and subsequently announced similar contamination of the pentavalent rotavirus vaccine (RV5) but recommended continued use of the product. We assessed the utilization of these vaccines in relation to the announcements.MethodsUsing claims submitted to a commercial health insurer for administration of RV1 and RV5, we estimated the number of administrations of the vaccines and the extent of switching between RV1 and RV5. Procedure codes on submitted claims identified vaccine administrations among infants ≤ 1 year old through 16 June 2010. Among infants who received a first dose of vaccine before the corresponding announcement, and whose second dose was anticipated following the announcement, we estimated the number who received no second dose of rotavirus vaccine.ResultsThere were 31 178 RV1 initiators and 514 357 RV5 initiators. We observed a 93% reduction in RV1 doses in the month following the recommended suspension of use, coupled with extensive switching to RV5 (90% of subsequent doses) and a reduction in second RV1 doses (from 35.5% incomplete to 40.9%). There was a 15% increase in number of RV5 administrations following announcement of its contamination, with little switching to RV1 but with a possible decrease in completion.ConclusionsRecommended suspension of RV1 use led to a substantial decrease in use and extensive switching to RV5. The announcement that RV5 was similarly contaminated, but without a corresponding recommendation to suspend use, had little effect on use. Copyright © 2012 John Wiley & Sons, Ltd.
New polyelectrolytes based on 4‐vinyl‐1,2,3‐triazole and 1‐vinylimidazole
Authors: Danilovtseva Elena N. , Chafeev Mikhail A. , Annenkov Vadim V. 
Published: January 2012

AbstractCopolymers of 4‐vinyl‐1,2,3‐triazole and 1‐vinylimidazole (VI) were obtained by radical copolymerization of (4‐vinyl‐1H‐1,2,3‐triazol‐1‐yl)methyl pivalate with VI followed by alkali hydrolysis. Reactivity ratios of the triazole and imidazole monomers are 0.51 and 0.30, respectively. Theoretical quantum‐chemical calculations by the PM3 semiempirical method give close values, which show that the obtained reactivity ratios reflect the activity of the vinyl groups. Polyelectrolyte properties of the copolymers were studied by potentiometric titration. Hydrogen bonds between the protonated triazole cycle and the triazole or imidazole units were found to considerably influence the solubility and solution properties of the copolymers. © 2012 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem, 2012
Validation of sleep‐related breathing disorder scale in Hong Kong Chinese snoring children
Authors: Chan Amy , Chan Chung‐Hong , Ng Daniel K. 
Published: January 2012

AbstractThe purpose of this study is to validate the previously‐validated Taiwan Chinese version of Sleep‐Related Breathing Disorder scale (SRBD scale) in Hong Kong Chinese snoring children. SRBD scale is an instrument used for prediction of obstructive sleep apnea syndrome. (OSA) The Chinese version of SRBD scale were previously translated and validated in Taiwan. The same questionnaire were administered in a group of 102 snoring children (mean age: 10.7 and 65 boys) from a sleep laboratory in Hong Kong before their sleep studies. The SRBD scores were then validated against the results from sleep studies. By using the definition of apnea‐hypopnea index larger than 1.5 as OSA, 28 children (27.5%) had polysomnography‐confirmed OSA. The sensitivity, specificity, positive likelihood ratio and negative likelihood ratio of the previously validated cut‐off of SRBD score > 0.33 for OSA were 0.5, 0.55, 1.12, and 0.90, respectively. The area under ROC curve was only 0.58, indicates suboptimal performance of SRBD score in predicting OSA. In summary, our study concluded that the previously reported Chinese SRBD scale is not accurate in identifying presence of OSA in Hong Kong Chinese snoring children. Pediatr Pulmonol. 2012. 47:795–800. © 2012 Wiley Periodicals, Inc.
Stability control and recurrent switching rules
Authors: Bacciotti Andrea 
Published: January 2012

SUMMARYRecently, it has been enlightened the interest of a class of switching rules with good properties, which are called eventually periodic: more precisely, it has been proven that a finite family of linear vector fields of can be stabilized by means of eventually periodic switching rules provided that it is asymptotically controllable and satisfies an additional finite time controllability condition. Unfortunately, simple examples point out that in general, eventually periodic switching rules are not robust with respect to state measurement errors.In this paper, we introduce a new type of switching rules with improved robustness properties, which are called recurrent switching rules. They are subject to the construction of a finite sequence of complete cones Γ1, … ,ΓH of . We shown that, if a stabilizing eventually periodic switching rule for is known, then Γ1, … ,ΓH can be constructed in such a way that is stabilized by any recurrent switching rule subject to Γ1, … ,ΓH. Copyright © 2012 John Wiley & Sons, Ltd.
Secure data transmission with cloud computing in heterogeneous wireless networks
Authors: Chu Chung‐Hua , Ouyang Yen‐Chieh , Jang Chang‐Bu 
Published: January 2012

ABSTRACTIn this paper, we propose a secure handoff scheme for data transmission in integration of 3G and 802.11 wireless local area networks (WLANs). The handoff between 802.11 WLAN and the 3G suffers from some drawbacks and has been hijacked through the middle of a communication session. We propose an architecture based on cloud computing to build our scheme to fix the problems in such heterogeneous wireless networks. Adaptive Key Exchange Protocol is proposed to protect data transmission as 3G users hand over to an 802.11 WLAN. The approach includes three phases, and all steps of each phase are protected by robust public‐key encryption. Therefore, no information can be hijacked in such environment. The security analysis shows that data transmission between 802.11 WLAN and 3G is robust and secure in various aspects. Copyright © 2012 John Wiley & Sons, Ltd.
Maladaptive Emotion Regulation is Related to Distressed Personalities in Cardiac Patients
Authors: Messerli‐Bürgy Nadine , Barth Jürgen , von Känel Roland , Schmid Jean‐Paul , Saner Hugo , Znoj Hansjörg 
Published: January 2012

AbstractBackgroundCardiac patients with Type D (‘distressed’) personality perceive more stress. It is unclear to what extent Type D personality might represent deficits in emotion regulation that are known to play an important role in the development of mental disorders. This study evaluated the relationship between emotion regulation and Type D personality and assessed the influence of mood and stress on Type D.MethodsEmotion regulation, mood, perceived stress and Type D personality were assessed in 163 cardiac patients.ResultsMaladaptive emotional regulation was more pronounced in Type D patients. Depressed mood and perceived partner‐related stress were higher in patients with Type D than in those with Non‐Type D. Regression models revealed a stronger association between emotion regulation and Type D personality (odds ratio = 3.16; 95% confidence interval = 1.53, 6.54) than for depressed mood (odds ratio = 1.19; 95% confidence interval = 1.02, 1.38).ConclusionPatients with deficits in emotion regulation are more likely to have Type D personality. Deficits in emotion regulation might be an agent for future intervention studies to change Type D and its prognostic effect. Copyright © 2012 John Wiley & Sons, Ltd.
Heedless programming: ignoring detectable error is a widespread hazard
Authors: Thimbleby Harold 
Published: January 2012

SUMMARYSoftware should be correct and robust. This paper suggests that we need forthright words for the failure of not being robust—heedless and heedlessness—and of recursively creating software (such as a compiler or virtual machine) that itself does not support dependable software development. Heedless programming is common, particularly affecting ‘trivial’ operations such as on numbers, and extends deep into programming language design and into the use of computers more widely, thus making robust, dependable applications of all sorts unnecessarily problematic. The paper defines the problem and presents a call to action to start addressing the problems identified. Copyright © 2012 John Wiley & Sons, Ltd.
Novel Pathways to Erythropoiesis Induced by Dimerization of Intracellular C-Mpl in Human Hematopoietic Progenitors
Authors: Parekh Chintan , Sahaghian Arineh , Kim William , Scholes Jessica , Ge Shundi , Zhu Yuhua , Asgharzadeh Shahab , Hollis Roger , Kohn Donald , Ji Lingyun , Malvar Jemily , Wang Xiaoyan , Crooks Gay 
Published: January 2012

Abstract
The cytokine thrombopoietin (Tpo) plays a critical role in hematopoiesis by binding to the extracellular domain and inducing homodimerization of the intracellular signaling domain of its receptor, c-Mpl. Mpl homodimerization can also be accomplished by binding of a synthetic ligand to a constitutively expressed fusion protein F36VMpl consisting of a ligand binding domain (F36V) and the intracellular signaling domain of Mpl. Unexpectedly, in contrast to Tpo stimulation, robust erythropoiesis is induced after dimerization of F36VMpl in human CD34+ progenitor cells. The goal of this study was to define the hematopoietic progenitor stages at which dimerization of intracellular Mpl induces erythropoiesis and the downstream molecular events that mediate this unanticipated effect. Dimerization (in the absence of erythropoietin and other cytokines) in human common myeloid progenitors and megakaryocytic erythroid progenitors caused a significant increase in CD34+ cells (p &lt; .01) and induced all stages of erythropoiesis including production of enucleated red blood cells. In contrast, erythropoiesis was not seen with Tpo stimulation. CD34+ cell expansion was the result of increased cell cycling and survival (p &lt; .05). Microarray profiling of CD34+ cells demonstrated that a unique transcriptional pattern is activated in progenitors by F36VMpl dimerization. Ligand-inducible dimerization of intracellular Mpl in human myeloerythroid progenitors induces progenitor expansion and erythropoiesis through molecular mechanisms that are not shared by Tpo stimulation of endogenous Mpl.
Disclosure of potential conflicts of interest is found at the end of this article.
Guiding Principles for Supporting New Literacies in Your Classroom
Authors: Karchmer‐Klein Rachel , Shinas Valerie Harlow 
Published: January 2012

AbstractIn this article, the authors propose four principles to guide teachers’ thinking as they use technology to support teaching and literacy learning in 21st century classrooms. Specifically, teachers must be aware of emerging technologies, recognize the complexities of new literacies, realize tech‐savvy students may not be skilled readers and writers of web‐based texts, and develop assessments to evaluate 21st century skills. Keeping these principles in mind will help teachers prepare students to become effective readers and writers of digital texts.
Reconceptualizing Critical Literacy Teaching in ESL Classrooms
Authors: Lau Sunny Man Chu 
Published: January 2012

AbstractAn instructional focus on critical literacy (CL) encourages students to become active readers and writers of cultural texts so that they can create their own meanings in order to shape and transform their social conditions (Lankshear & McLaren, 1993; Shor, 1992). It is, however, seldom pursued with English learners (ELs) because teachers assume that students’ limitations in English will preclude academic engagement with complex social and moral issues. The participatory action research described in this article challenges this assumption (Lau, 2010). Working with an ESL teacher in the Greater Toronto Area, I documented the progress of Grades 7 and 8 ELs engaged in CL work despite their limited English proficiency
Conversations with Leaders: Principles of Effective Writing Instruction
Authors: Zumbrunn Sharon , Krause Keegan 
Published: January 2012

AbstractFindings from research demonstrate that student writing proficiency and classroom writing instruction is a national concern (Applebee & Langer, 2006, 2009; Graham, Harris, Fink‐Chorzempa, & MacArthur, 2003; Persky, Daane, & Jin, 2003). This qualitative study explored principles of effective writing instruction through the perspectives of leading authorities in the field of writing. Five major themes of effective writing instruction emerged: (1) Effective writing instructors realize the impact of their own writing beliefs, experiences, and practices; (2) Effective writing instruction encourages student motivation and engagement; (3) Effective writing instruction begins with clear and deliberate planning, but is also flexible; (4) Effective writing instruction and practice happens every day; and (5) Effective writing instruction is a scaffolded collaboration between teachers and students. This article summarizes recommendations for best practices in the writing classroom.
Replaying history on process models for conformance checking and performance analysis
Authors: van der Aalst Wil , Adriansyah Arya , van Dongen Boudewijn 
Published: January 2012

AbstractProcess mining techniques use event data to discover process models, to check the conformance of predefined process models, and to extend such models with information about bottlenecks, decisions, and resource usage. These techniques are driven by observed events rather than hand‐made models. Event logs are used to learn and enrich process models. By replaying history using the model, it is possible to establish a precise relationship between events and model elements. This relationship can be used to check conformance and to analyze performance. For example, it is possible to diagnose deviations from the modeled behavior. The severity of each deviation can be quantified. Moreover, the relationship established during replay and the timestamps in the event log can be combined to show bottlenecks. These examples illustrate the importance of maintaining a proper alignment between event log and process model. Therefore, we elaborate on the realization of such alignments and their application to conformance checking and performance analysis. © 2012 Wiley Periodicals, Inc.This article is categorized under:

Algorithmic Development > Association Rules
Algorithmic Development > Spatial and Temporal Data Mining
Application Areas > Business and Industry
Fundamental Concepts of Data and Knowledge > Data Concepts
A Model of Sexually and Physically Victimized Women's Process of Attaining Effective Formal Help over Time: The Role of Social Location, Context, and Intervention
Authors: Kennedy Angie C. , Adams Adrienne , Bybee Deborah , Campbell Rebecca , Kubiak Sheryl Pimlott , Sullivan Cris 
Published: January 2012

AbstractAs empirical evidence has demonstrated the pervasiveness of sexual assault and intimate partner violence in the lives of women, and the links to poor mental health outcomes, attention has turned to examining how women seek and access formal help. We present a conceptual model that addresses prior limitations and makes three key contributions: It foregrounds the influence of social location and multiple contextual factors; emphasizes the importance of the attainment of effective formal help that meets women's needs and leads to positive mental health outcomes; and highlights the role of interventions in facilitating help attainment. We conclude with research and practice implications.
36 months observational clinical study of 38 adult Pompe disease patients under alglucosidase alfa enzyme replacement therapy
Authors: Regnery Caroline , Kornblum Cornelia , Hanisch Frank , Vielhaber Stefan , Strigl‐Pill Nicola , Grunert Birgit , Müller‐Felber Wolfgang , Glocker Franz Xaver , Spranger Matthias , Deschauer Marcus , Mengel Eugen , Schoser Benedikt 
Published: January 2012

AbstractObjectivesGlycogen storage disease type 2(GSD2)/Pompe disease is characterized by respiratory and skeletal muscle weakness and atrophy, resulting in functional disability and reduced life span.MethodsWe present an open‐label, investigator‐initiated observational study of alglucosidase alfa enzyme replacement therapy (ERT) in 38 adult‐onset GSD2 patients (20 female, 18 male) with a mean age at disease onset of 36.2 ± 10.5 years. Mean delay between symptom onset and start of ERT was 14.5 ± 7.2 years. Assessments included serial Walton Gardner Medwin scale, arm function tests, timed 10‐meter walk tests, 4‐stair climb tests, modified Gowers’ maneuvers, 6‐minute walk test (6MWT), MRC sum score, forced vital capacities (FVC), creatine kinase (CK) levels, and SF‐36 self‐reporting questionnaires. All tests were performed at baseline and every 12 months for 36 months of ERT.ResultsIn the 6MWT we found 21 patients able to walk at baseline a mean distance of 312 ± 165.5 m, improving to 344 ± 165.8 m after 12 months (p = 0.006), remaining at 356.4 ± 155.9 m at 24 months (p = 0.033), and declining to 325.6 ± 174.8 m after 36 months of ERT (p = 0.49, n.s.). The mean FVC in 28 patients was 80.27 ± 14.08% of predicted normal at baseline, after 12 months 79.19 ± 13.09%, at 24 months 78.62 ± 16.55%, and 77.19 ± 18.05% after 36 months. Only mean CK levels were significantly decreased by 8.8% (p = 0.041). All other tests were statistically non‐significant changed.ConclusionOur data denote a rather variable course of neuromuscular deficits in chronic adult‐onset Pompe patients during 36 months of alglucosidase alfa ERT.
Complications of pamidronate therapy in paediatric osteoporosis
Authors: Chilbule Sanjay K. , Madhuri Vrisha 
Published: January 2012

Purpose Pamidronate, used for the treatment of paediatric osteoporosis, reduces the fracture rate and improves ambulatory status. Intravenous pamidronate therapy has known complications which have not been stratified based on its dose and distribution. This study aims to assess the early minor and major medical and late surgical complications and the effect of the dose and regimen of infusion on these events in paediatric osteoporosis. Study design Retrospective cohort. Materials and methods Three regimens for pamidronate infusion were followed in sequential periods in 10 years. Regimen A delivered 1.5 mg/kg/day as a single dose once in 3 months. Regimen B delivered 2 mg/kg/day for 3 days twice a year, while regimen C delivered 1 mg/kg/day for 3 days every 3–4 months. Adverse events were classified as early (major and minor) or late (surgical). Results Forty-eight children received 158 infusions using one of the three regimens. Twenty-nine complications occurred in 24 children. A significant difference in the complication rate was present among the three regimens ( P = 0.005). Nineteen children had minor complications, mainly febrile reaction or asymptomatic hypocalcaemia. Four major complications consisting of one seizure, one respiratory distress and two hypocalcaemic tetany were encountered, all with regimen B. Intraoperative complication faced was loss of position due to splintering of the cortex while rush rodding. This was seen in 20% of the long bone segments operated in those who received pamidronate as compared to 4.4% of the segments which were operated prior to the initiation of pamidronate therapy; the odds of splintering were 5.4 times higher for those patients who were bone segment rodded after pamidronate therapy. Discussion Intravenous pamidronate is associated with complications in 50% of children with paediatric osteoporosis, with a dose-dependent significant difference. Major complications are not uncommon with higher doses and can be avoided by increasing the number of doses per year and decreasing the dose per cycle. Surgical difficulty, when possible, can be avoided by correcting any major deformities at presentation prior to the induction of pamidronate therapy.
Surgical Count Practice Variability and the Potential for Retained Surgical Items
Authors: Edel Elizabeth Morell 
Published: January 2012

AbstractValidating existing count practices and reducing individual practice variance are necessary to decrease the risk for retained surgical items. A quality improvement project was undertaken at one large city hospital to identify best practice and eliminate variability in count practices. The project included an analysis of 20 surgical count policies from hospitals across the country and a review of count practices among nurses and surgical technologists at the facility. Assessment of the policies and practices indicated that clinical practice requirements in the policies varied greatly, and there was a high degree of count practice variability among staff members. The facility OR manager and OR quality coordinator collaborated with staff nurses and surgical technologists to identify practices that created variability and then addressed each one to create a new count policy and reduce the risk of retained surgical items.