bluuebunny/crossref_metadata_2025_split huggingface dataset:
Synthesis and Microwave Dielectric Properties of Sm2SiO5 Ceramics
Authors: Wu Songping , Jiang Chan , Mei Youxian , Tu Weiping 
Published: November 2011

The Sm2SiO5 ceramics were synthesized and their microwave dielectric properties were investigated. The pure monoclinic Sm2SiO5 phase could be obtained when the molar ratio of Sm2O3/SiO2 was 1:1.05 at 1350°C. A small amount of hexagonal Sm4(SiO4)3 second phase occurred as temperature increased. The relative density of Sm2SiO5 ceramics increased with increasing temperature. The Sm2SiO5 ceramics sintered at 1500°C exhibited microwave dielectric properties: a dielectric constant (εr) of 8.44, a quality factor (Q × f) of 64 000 GHz, and a temperature coefficient of resonant frequency (τf) of −37 ppm/°C. The Sm2SiO5 ceramics have a wide sintering temperature region and small negative τf values. They are promising candidate materials for millimeter‐wave devices.
The chemoadjuvant potential of grape seed procyanidins on p53‐related cell death in oral cancer cells
Authors: Lin Yaoh‐Shiang , Chen Su‐Feng , Liu Chia‐Lin , Nieh Shin 
Published: November 2011

J Oral Pathol Med (2012) 41: 322–331Background:  To clarify the efficacy of grape seed procyanidin (GSP) on antiproliferative effects related to p53 functional status of oral squamous cell carcinoma (OSCC) for its chemoadjuvant potential.Methods:  We used GSP to investigate SCC‐25 cells with wild‐type p53 gene and OEC‐M1 cells with mutant p53 gene for the assessment of antiproliferative effects including cell viability, cell cycle, apoptosis, migration and invasion potential, and alterations of associated oncoproteins involved in cellular and molecular events.Results:  The findings suggest that GSP on OEC‐M1 cells leads to cell cycle arrest by increasing the expression of p21Cip1/p27Kip1 protein without functioning mitochondria‐mediated apoptosis, whereas GSP on SCC‐25 cells inhibits cell proliferation via both G1‐phase arrest and mitochondria‐mediated apoptosis in a dose‐dependent manner as a result of alterations of Bcl‐2. GSP also inhibits the migration and invasion of both cells, which are associated with the suppression of matrix metalloproteinases (MMPs), MMP‐2 and MMP‐9.Conclusion:  Antiproliferative effectiveness of GSP is closely associated with the p53 status of OSCC cells. GSP displays chemoadjuvant potential via cell cycle blockage and apoptotic induction. Our findings clearly suggest that GSP may play a role as a novel chemopreventive or therapeutic agent for OSCC.
Exploratory study on the effect of osteoactivin on bone formation in the rat critical‐size calvarial defect model
Authors: Bateman J. P. , Safadi F. F. , Susin C. , Wikesjö U. M. E. 
Published: November 2011

Bateman JP, Safadi FF, Susin C, Wikesjö UME. Exploratory study on the effect of osteoactivin on bone formation in the rat critical‐size Calvarial defect model. J Periodont Res 2012; 47: 243–247. © 2011 John Wiley & Sons A/SBackground and Objective:  Osteoactivin is a novel glycoprotein shown to exhibit an important role in regulating osteoblast differentiation and function. The aim of the present study was to evaluate the potential of osteoactivin to support bone regeneration using an established defect model.Material and Methods:  Critical‐size, 8‐mm‐diameter through‐and‐through calvarial osteotomy defects were created in 60 adult male Sprague‐Dawley rats. Test animals received 0.1 mL of osteoactivin in phosphate‐buffered saline (50 μg/mL) soak‐loaded onto an absorbable collagen sponge. Controls received 0.1 mL of phosphate‐buffered saline soak‐loaded onto the absorbable collagen sponge or no further intervention (sham‐surgery). The animals were euthanized 2 and 4 wk after treatment and histometric analyses were performed.Results:  The absorbable collagen sponge control (mean ± standard deviation: 40.9 ± 26.9%) showed borderline significant greater bone fill compared with sham‐surgery (22.9 ± 15.8%; p = 0.10) and osteoactivin (20.2 ± 11.8%; p = 0.07) treatments at 2 wk. In contrast, osteoactivin (84.7 ± 15.8%) showed significantly greater bone fill than sham‐surgery (28.4 ± 9.6%; p < 0.001) and absorbable collagen sponge (41.8 ± 22.1%; p < 0.001) at 4 wk. No animals receiving sham‐surgery or absorbable collagen sponge exhibited complete bone fill at 4 wk while 70% of the animals receiving osteoactivin showed complete bone fill.Conclusion:  Osteoactivin demonstrates a significant potential to support bone regeneration/formation. Studies using discriminating large animal models are necessary to explore clinical application for periodontal and craniofacial indications.
Basic fibroblast growth factor inhibits osteogenic differentiation of stem cells from human exfoliated deciduous teeth through ERK signaling
Authors: Li B , Qu C , Chen C , Liu Y , Akiyama K , Yang R , Chen F , Zhao Y , Shi S 
Published: November 2011

Oral Diseases (2012) 18, 285–292Objective:  Stem cells from human exfoliated deciduous teeth (SHED) are a unique postnatal stem cell population capable of regenerating mineralized tissue and treating immune disorders. However, the mechanism that controls SHED differentiation is not fully understood. Here, we showed that basic fibroblast growth factor (bFGF) treatment attenuated SHED‐mediated mineralized tissue regeneration through activation of the extracellular signal‐regulated kinase (ERK) 1/2 pathway.Material and Method: The level of mineralized nodule formation was assessed by alizarin red staining. Expression levels of osteogenic genes, osteocalcin and runt‐related transcription factor 2, were examined by RT‐PCR. Subcutaneous implantation approach was used to assess in vivo bone formation. Downstream signaling pathways of bFGF were examined by Western blotting.Result:  Activation of ERK1/2 signaling by bFGF treatment inhibited WNT/β‐catenin pathway, leading to osteogenic deficiency of SHED. ERK1/2 inhibitor treatment rescued bFGF‐induced osteogenic differentiation deficiency.Conclusion:  These data suggest that bFGF inhibits osteogenic differentiation of SHED via ERK1/2 pathway. Blockade ERK1/2 signaling by small molecular inhibitor treatment improves bone formation of SHED after bFGF treatment.
Indocyanine green fluorescence‐guided sentinel lymph node biopsy in dermato‐oncology
Authors: Stoffels Ingo , von der Stück Hannah , Boy Christian , Pöppel Thorsten , Körber Nina , Weindorf Maren , Dissemond Joachim , Schadendorf Dirk , Klode Joachim 
Published: November 2011

SummaryBackground: Sentinel lymph node biopsy (SLNB) for cutaneous malignancies usually carried out with radioactive nanocolloids (Tc‐99m). The SLNE is controversially discussed internationally. This is especially given to the high false‐negative rate up to 44 %. An alternative could be the fluorescent dye indocyanine green (ICG).Material and Methods: We investigated the advantage of intraoperative fluorescence detection of lymphatic vessels and SLN with a Near‐Infrared (NIR) camera in comparison to conventional methods using preoperative lymphoscintigraphy and SPECT/CT in 22 patients with malignant melanoma.Results: A total of 61 SLNs were removed in 22 operative procedures. In 7 SLN (10.3 %; 7/68) the histopathological assessment could demonstrate a metasta‐tic involvement. 11 additional SLN (19.1 %) in 8 patients were only identified using the fluorescent labeling. Two of these additional SLN (9.1 %; 2/22) showed metastatic involvement.Conclusion: The ICG fluorescence‐guided SLNB is an innovative imaging technique for dermato‐oncology, reliable and providing additional information in the detection of SLN. Therefore SLNB with fluorescence‐dye is an attractive option with intraoperative real‐time lymphoscintigraphy to improve the detection of SLN in cutaneous malignancies and potential reduction of the false negative rate in SLN.
Congenital central hypoventilation syndrome and hypoglycaemia
Authors: Farina Maria I. , Scarani Roberto , Po’ Chiara , Agosto Caterina , Ottonello Giancarlo , Benini Franca 
Published: November 2011

AbstractCongenital central hypoventilation syndrome (CCHS) is a rare genetic disorder typically presenting in infants with an impaired automatic control of breathing, particularly during sleep, and often associated with variable patterns of autonomic nervous system dysregulations. We studied three children who had CCHS associated with episodes of severe hypoglycaemia and hyperinsulinaemia; we discuss the possible relationship with impaired dopamine‐beta‐hydroxylase function.Conclusion:  Hypoglycaemia and hyperinsulinaemia might be suspected in children with CCHS presenting with seizures and hyperhydrosis; though, further studies are needed to confirm this association.
Community‐level seedling dynamics in Mediterranean forests: uncoupling between the canopy and the seedling layers
Authors: Pérez‐Ramos Ignacio M. , Marañón Teodoro 
Published: November 2011

AbstractQuestionsBased on comparisons between canopy and seedling layers, which woody species of a Mediterranean forest community, if any, are recruitment‐limited? What abiotic and biotic factors predominantly affect seedling density and survival for each species? How spatially consistent are the two demographic processes? What are the ecological implications of these findings for forest stand dynamics and species co‐existence?LocationMediterranean oak forests in southern Spain.MethodsWe present the results of a community‐level study conducted over 4 yr in three Mediterranean forest sites in order to determine species‐specific recruitment patterns. We analyse the most influential factors for seedling dynamics in the main co‐occurring woody plant species.ResultsWe found a strong uncoupling between the canopy and the seedling layer, irrespective of the structural characteristics of the forest site. Some of the most dominant species in the overstorey, such as Quercus suber, Arbutus unedo or Pistacia lenticus, were scarcely represented as seedlings in the understorey, suggesting problems of recruitment limitation. In contrast, other shrub species, such as Viburnum tinus or Phillyrea latifolia, showed large seedling densities with a high probability of survival despite their low frequencies as adults in the canopy. Species composition and abundance in the seedling layer were the result of the combined effect of different mechanisms involving both seed dispersal and the environmental filtering of seedling establishment. However, the factors that determined seedling spatial patterns were inconsistent with those that influenced seedling survival, probably as a consequence of different habitat associations through subsequent recruitment life stages.ConclusionsThe community‐wide approach enabled us to detect substantial differences among species in their spatial and temporal recruitment patterns, as well as in the relative importance of factors affecting seedling dynamics. The differential effect that spatial micro‐heterogeneity exerted for each of the studied species suggests the existence of multiple species‐specific regeneration niches, favouring species co‐existence and the maintenance of these diverse forest communities. However, the observed recruitment limitation for some dominant forest species will probably result in future shifts in species composition.
Correlation of vitamin A nutritional status on alpha‐tocopherol in the colostrum of lactating women
Authors: de Lira Larissa Queiroz , Lima Mayara Santa Rosa , de Medeiros Jovilma Maria Soares , da Silva Isabelle Ferreira , Dimenstein Roberto 
Published: November 2011

AbstractThe adequate supply of vitamins A and E to newborns is essential. However, factors such as maternal nutritional status and nutrient interaction may limit its bioavailability. The aim of this study was to establish nutritional status for vitamins A and E and evaluate the correlation of retinol on colostrum alpha‐tocopherol in lactating women. A total of 103 lactating women were recruited at a Brazilian public maternity hospital. Fasting serum and colostrum samples were collected in the immediate post‐partum. Retinol and alpha‐tocopherol levels were determined by high‐performance liquid chromatography and nutritional status for these vitamins was defined from specific cut‐off points for serum and colostrum. Mean serum and colostrum retinol (1.49 µmol L−1, 2.18 µmol L−1) and alpha‐tocopherol (26.4 µmol L−1, 26.1 µmol L−1) indicated satisfactory biochemical status. However, we found a prevalence of subclinical deficiency of vitamin A and vitamin E in serum (15.5% and 16%) and colostrum (50% and 60%). Lactating women with serum retinol ≥ 1.05 µmol L−1 showed an inverse correlation between serum retinol and alpha‐tocopherol concentration in the colostrum (P = 0.008, r = −0.28). This association was not observed in serum level < 1.05 µmol L−1. The nutritional status of lactating women for vitamins A and E was adequate, although there is a risk of subclinical deficiency. The negative correlation of serum retinol on alpha‐tocopherol concentration in the colostrum must be carefully evaluated in situations of vitamin A supplementation, because alpha‐tocopherol bioavailability in maternal milk may be compromised.
A scoping review and research synthesis on financing and regulating oral care in long‐term care facilities
Authors: MacEntee Michael I. , Kazanjian Arminee , Kozak Jean‐Francois , Hornby Kathy , Thorne Sally , Kettratad‐Pruksapong Matana 
Published: November 2011

doi: 10.1111/j.1741‐2358.2011.00575.xA scoping review and research synthesis on financing and regulating oral care in long‐term care facilitiesBackground:  Oral health care for frail elders is grossly inadequate almost everywhere, and our knowledge of regulating and financing oral care in this context is unclear.Objective:  This scoping study examined and summarised the published literature available and the gaps in knowledge about regulating and financing oral care in long‐term care (LTC) facilities.Methods:  We limited the electronic search to reports on regulating and financing oral care, including reports, commentaries, reviews and policy statements on financing and regulating oral health‐related services.Results:  The broad electronic search identified 1168 citations, which produced 42 references, including 26 pieces of grey literature for a total of 68 papers. Specific information was found on public and private funding of care and on difficulties regulating care because of professional segregation, difficulties assessing need for care, uncertainty on appropriateness of treatments and issues around scope of professional practice. A wide range of information along with 19 implications and 18 specific gaps in knowledge emerged relevant to financing and regulating oral healthcare services in LTC facilities.Conclusions:  Effort has been given to enhancing oral care for frail elders, but there is little agreement on how the care should be regulated or financed within the LTC sector.
Residual ridge atrophy in complete denture wearers and relationship with densitometric values of a cervical spine: a hierarchical regression analysis
Authors: Kovačić Ivan , Knezović Zlatarić Dubravka , Čelebić Asja 
Published: November 2011

doi: 10.1111/j.1741‐2358.2011.00589.xResidual ridge atrophy in complete denture wearers and relationship with densitometric values of a cervical spine: a hierarchical regression analysisBackground:  The rate of residual ridge atrophy (RRR) and its association with mineral density of other bones have not yet been fully explained.Objective:  To measure RRR over a 5‐year period in complete denture wearers and relate it to the density of a cervical spine (CSBD).Materials and methods:  Sixty‐two patients (different gender, age, body mass index, duration of edentulousness (DE) and different denture‐wearing habits) participated. A copper stepwedge was attached to the cassette, and 50 lateral radiograms met the criteria to be included.Results:  A significant decrease in vertical height was observed in all measured sites. The amount of RRR was highest in frontal areas of both jaws and decreased gradually towards lateral regions. Hierarchical regression analysis revealed that the amount of RRR in the maxillary frontal area could be explained up to 48.4% by the variable DE and only up to 6.1% by the CSBD, while gender had almost no influence (1%). Similar results were obtained for the lateral maxillary RRR (33.9%; 7%; 2%), frontal mandibular RRR (40; 8.4; 0.4%) and lateral mandibular RRR (31.5%; 3.4%; 7.7%).Conclusion:  Skeletal bone density, reflecting systemic and hereditary factors, is weakly related to RRR (3.4–8.4%).
A 3‐year longitudinal study of quality‐of‐life outcomes of elderly patients with implant‐ and tooth‐supported fixed partial dentures in posterior dental regions
Authors: Petricevic Nikola , Celebic Asja , Rener‐Sitar Ksenija 
Published: November 2011

doi: 10.1111/j.1741‐2358.2011.00592.x

A 3‐year longitudinal study of quality‐of‐life outcomes of elderly patients with implant‐ and tooth‐supported fixed partial dentures in posterior dental regionsBackground:  Clinical studies have mainly been focused on oral health‐related quality‐of‐life (OHRQoL) outcomes of removable dentures.Objective:  To evaluate therapy of elderly patients with implant‐supported fixed partial dentures (IFPD) and tooth‐supported fixed partial dentures (FPD) in the posterior dental regions.Patients and methods:  The OHIP49 was used to measure OHRQoL in 64 patients with IFPD and 38 patients with FPD, before, 3 weeks and 3 years after rehabilitation. A control group (CG) consisted of 62 individuals.Results:  The Oral Health Impact Profile questionnaire (OHIP) follow‐up scores of the patients with FPD and the patients with IFPD were significantly smaller in comparison with the baseline scores (p < 0.01). The OHIP scores were further reduced at the 3‐year follow‐up. The patients with IFPD had significantly higher scores than the patients with FPD and the CG at the baseline and at the follow‐ups. In the patients with FPD, both age groups (≤60 and >60) showed equal improvement of the OHRQoL. In the IFPD group, patients older than 60 years showed better improvement (p < 0.05). There were no significant differences dependent on gender and antagonistic teeth (p > 0.05).Conclusion:  The FPD and the IFPD treatment showed significant improvement of OHRQoL. The FPD treatment improved OHRQoL equally in both age groups, while the IFPD treatment improved OHRQoL better in older patients.
PP3 forms stable tetrameric structures through hydrophobic interactions via the C‐terminal amphipathic helix and undergoes reversible thermal dissociation and denaturation
Authors: Pedersen Lise R. L. , Nielsen Søren B. , Hansted Jon G. , Petersen Torben E. , Otzen Daniel E. , Sørensen Esben S. 
Published: November 2011

The milk protein proteose peptone component 3 (PP3), also called lactophorin, is a small phosphoglycoprotein that is expressed exclusively in lactating mammary tissue. The C‐terminal part of the protein contains an amphipathic helix, which, upon proteolytic liberation, shows antibacterial activity. Previous studies indicate that PP3 forms multimeric structures and inhibits lipolysis in milk. PP3 is the principal component of the proteose peptone fraction of milk. This fraction is obtained by heating and acidifying skimmed milk, and in the dairy industry milk products are also typically exposed to treatments such as pasteurization, which potentially could result in irreversible denaturation and inactivation of bioactive components. We show here, by the use of CD, that PP3 undergoes reversible thermal denaturation and that the α‐helical structure of PP3 remains stable even at gastric pH levels. This suggests that the secondary structure survives treatment during the purification and possibly some of the industrial processing of milk. Finally, asymmetric flow field‐flow fractionation and multi‐angle light scattering reveal that PP3 forms a rather stable tetrameric complex, which dissociates and unfolds in guanidinium chloride. The cooperative unfolding of PP3 was completely removed by the surfactant n‐dodecyl‐β‐d‐maltoside and by oleic acid. We interpret this to mean that the PP3 monomers associate through hydrophobic interactions via the hydrophobic surface of the amphipathic helix. These observations suggest that PP3 tetramers act as reservoirs of PP3 molecules, which in the monomeric state may stabilize the milk fat globule.Structured digital abstract
PP3 and PP3 bind by circular dichroism (View interaction)
PP3 and PP3 bind by molecular sieving (View interaction)
PP3 and PP3 bind by fluorescence technology (View interaction)
PP3 and PP3 bind by molecular sieving (View interaction)
On the X-ray low- and high-velocity outflows in active galactic nuclei
Authors: Ramírez J. M. , Tombesi F. 
Published: November 2011

Abstract
An exploration of the relationship between bolometric luminosity and outflow velocity for two classes of X-ray outflows in a large sample of active galactic nuclei has been performed. We find that line radiation pressure could be one physical mechanism that might accelerate the gas we observe in warm absorber, v ∼ 100–1000 km s−1, and on comparable but less stringent grounds the ultrafast outflows, v ∼ 0.03–0.3c. If comparable with the escape velocity of the system, the first is naturally located at distances of the dusty torus, ≈1 pc, and the second at subparsec scales, ≈0.01 pc, in accordance with large set of observational evidence existing in the literature. The presentation of this relationship might give us key clues for our understanding of the different physical mechanisms acting in the centre of galaxies, the feedback process and its impact on the evolution of the host galaxy.
Observational evidence for a correlation between jet power and black hole spin
Authors: Narayan Ramesh , McClintock Jeffrey E. 
Published: November 2011

Abstract
We show that the 5-GHz radio flux of transient ballistic jets in black hole binaries correlates with the dimensionless black hole spin parameter a* estimated via the continuum-fitting method. The data suggest that jet power scales either as the square of a* or as the square of the angular velocity of the horizon ΩH. This is the first direct evidence that jets may be powered by black hole spin energy. The observed correlation validates the continuum-fitting method of measuring spin. In addition, for those black holes that have well-sampled radio observations of ballistic jets, the correlation may be used to obtain rough estimates of their spins.