bluuebunny/crossref_metadata_2025_split huggingface dataset:
Development of rapid and simultaneous quantitative method for green tea catechins on the bioanalytical study using UPLC/ESI‐MS
Authors: Misaka Shingen , Kawabe Keisuke , Onoue Satomi , Werba José Pablo , Giroli Monica , Kimura Junko , Watanabe Hiroshi , Yamada Shizuo 
Published: April 2012

ABSTRACTA rapid and quantitative analytical method for the simultaneous determination of green tea catechins using ultra‐performance liquid chromatography/electrospray ionization–mass spectrometry was developed. Total analytical run time was 3.5 min for the detection of (−)‐epicatechin (EC), (−)‐epicatechin‐3‐O‐gallate (ECG), (−)‐epigallocatechin (EGC), (−)‐epigallocatechin‐3‐O‐gallate (EGCG) and myricetin as the internal standard (IS) in rat plasma. The calibration curves were linear over the range of 10–5000 ng/mL for all the catechins. The inter‐ and intra‐day precision (relative standard deviation) and accuracy (percentage deviation) of the method were both lower than 10%. The average extraction recoveries in plasma ranged from 68.5 to 86.5%, and the lower limits of quantification of EC, EGC, ECG and EGCG were 10 ng/mL with a signal‐to‐noise ratio of >10. The assay developed was successfully applied to a pharmacokinetic study of catechins following intravenous and intragastric administrations of green tea extract in rats. Plasma concentrations of four catechins were detected up to 5–24 h after administration, and the pharmacokinetic parameters of catechins were in agreement with previous studies. From these findings, taken together with the high productivity and precision, the developed method could be a reliable and reproducible tool for the evaluation of pharmacokinetic properties of catechins. Copyright © 2012 John Wiley & Sons, Ltd.
Retracing the etymology of terms in neuroanatomy
Authors: Paluzzi Alessandro , Fernandez‐Miranda Juan , Torrenti Matthew , Gardner Paul 
Published: April 2012

AbstractResearching the origin of the terms that we use to identify neuroanatomical structures is a helpful and fascinating exercise. It can provide neuroscientists with a better insight and understanding of the macroscopic anatomy of the cranium and its contents. It can also help the novice to this discipline to become acquainted with structures whose three dimensional anatomy is often difficult to appreciate. The purpose of this article was to investigate the etymology of some of the terms referring to the macroscopic anatomical structures of the skull and the intracranial cavity. We observed how each name unravels an interesting story, sometimes linked to mythological creatures, other times to the shape of animals or objects and tools of everyday life. We conclude that even without a deep knowledge of the Greek, Latin, or Arabic language, learning who described a particular structure and how they decided to name it, makes the study of neuroanatomy more complete and fulfilling. Clin. Anat. 25:1005–1014, 2012. © 2012 Wiley Periodicals, Inc.
Accurate measurement of oxygen consumption in children undergoing cardiac catheterization
Authors: Li Jia 
Published: April 2012

AbstractOxygen consumption (VO2) is an important part of hemodynamics using the direct Fick principle in children undergoing cardiac catheterization. Accurate measurement of VO2 is vital. Obviously, any error in the measurement of VO2 will translate directly into an equivalent percentage under‐ or overestimation of blood flows and vascular resistances. It remains common practice to estimate VO2 values from published predictive equations. Among these, the LaFarge equation is the most commonly used equation and gives the closest estimation with the least bias and limits of agreement. However, considerable errors are introduced by the LaFarge equation, particularly in children younger than 3 years of age. Respiratory mass spectrometry remains the “state‐of‐the‐art” method, allowing highly sensitive, rapid and simultaneous measurement of multiple gas fractions. The AMIS 2000 quadrupole respiratory mass spectrometer system has been adapted to measure VO2 in children under mechanical ventilation with pediatric ventilators during cardiac catheterization. The small sampling rate, fast response time and long tubes make the equipment a unique and powerful tool for bedside continuous measurement of VO2 in cardiac catheterization for both clinical and research purposes. © 2012 Wiley Periodicals, Inc.
Yield Optimization in a Cycled Trickle‐Bed Reactor: Ethanol Catalytic Oxidation as a Case Study
Authors: Ayude A. , Cassanello M. , Martínez O. , Haure P. 
Published: April 2012

AbstractThe effect of slow ON‐OFF liquid flow modulation on the yield of consecutive reactions is investigated for oxidation of aqueous ethanol solutions using a 0.5 % Pd/Al2O3 commercial catalyst in a laboratory trickle‐bed reactor. Experiments with modulated liquid flow rate (MLFR) were performed under the same hydrodynamic conditions (degree of wetting, liquid holdup) as experiments with constant liquid flow rate (CLFR). Thus, the impact of the duration of wet and dry cycles as well as the period can be independently investigated. Depending on cycling conditions, acetaldehyde or acetic acid production is favored with MLFR compared to CLFR. Results suggest both the opportunity and challenge of finding a way to tune the cycling parameters for producing the most appropriate product.
Testing for generalized linear mixed models with cluster correlated data under linear inequality constraints
Authors: Davis Karelyn A. , Park Chul G. , Sinha Sanjoy K. 
Published: April 2012

AbstractGeneralized linear mixed models (GLMMs) are often used for analyzing cluster correlated data, including longitudinal data and repeated measurements. Full unrestricted maximum likelihood (ML) approaches for inference on both fixed‐and random‐effects parameters in GLMMs have been extensively studied in the literature. However, parameter orderings or constraints may occur naturally in practice, and in such cases, the efficiency of a statistical method is improved by incorporating the parameter constraints into the ML estimation and hypothesis testing. In this paper, inference for GLMMs under linear inequality constraints is considered. The asymptotic properties of the constrained ML estimators and constrained likelihood ratio tests for GLMMs have been studied. Simulations investigated the empirical properties of the constrained ML estimators, compared to their unrestricted counterparts. An application to a recent survey on Canadian youth smoking patterns is also presented. As these survey data exhibit natural parameter orderings, a constrained GLMM has been considered for data analysis.The Canadian Journal of Statistics40: 243–258; 2012 © 2012 Crown in the right of Canada
Evaluation of intra‐group optimistic data replication in P2P groupware systems
Authors: Xhafa Fatos , Potlog Alina‐Diana , Spaho Evjola , Pop Florin , Cristea Valentin , Barolli Leonard 
Published: April 2012

SummaryPeer‐to‐peer (P2P) computing systems have become very popular during the last years because of their ability to scale to a large number of users and efficient communication among peers. They can support complex computational processes, beyond simple file sharing, while offering advantages of decentralized distributed systems. However, such systems may suffer from availability and reliability. To increase availability and reliability, and therefore, improve the perception of peers, yielding to fast response times and rich experience, data replication techniques are the foremost means in such systems. Indeed, in many P2P applications, for example, in a groupware, documents generated along application life cycle can change over time. The need is then to efficiently replicate dynamic documents and data to support group processes and collaboration. In this paper, we propose a replication system for documents structured as XML files and evaluate it under different scenarios. The proposed system has a super‐peer architecture that provides fast consistency for late joining peers. It uses optimistic replication techniques with propagating update operations from source to destination node in push mode. The system is suitable for asynchronous collaboration in online collaborative teams accomplishing a common project in a P2P environment. Copyright © 2012 John Wiley & Sons, Ltd.
Photoinduced Symmetry‐Breaking Charge Separation
Authors: Vauthey Eric 
Published: April 2012

AbstractMolecular systems where several apparently equivalent charge separation pathways exist upon photoexcitation are presented. They encompass MQn (n≥2) architectures, where M is a chromophore and Q an electron transfer quencher (either donor or acceptor), and M–M systems where M acts as both electron donor and acceptor. In all cases, charge separation involves symmetry breaking. The conditions for such process to be operative as well as the origin of the symmetry breaking are discussed.
Facile Synthesis of Uniform CdS Hollow Spheres in an Ethanol System and Their Enhanced Photocatalytic Activity
Authors: Wang Xiufang , Yuan Shizhen , Chen Guangmei 
Published: April 2012

AbstractThe monodisperse, flowerlike CdS hollow spheres have been successfully synthesized by employing sulfur as the sulfate sources from a solution of H4SiW12O40 (SiW12) in ethanol through UV irradiation. The SiW12 that serves as photocatalyst plays a very important role on the synthesis of CdS crystals. The morphologies of the synthesized CdS crystals could be controlled by adjusting experimental parameters, such as initial precursor ratios, reaction time, and concentration of reagents. The possible mechanism of formation for the CdS nanostructures is proposed based on the experimental results. The Brunauer–Emmett–Teller (BET) surface area of the CdS hollow spheres calculated from the N2 adsorption isotherm is 175.8 m2 g−1, which is much larger than the value reported in previous reports. The optical properties of CdS hollow structures have also been studied. Importantly, the CdS hollow nanostructures have extraordinary photocatalytic activity for the photodegradation of rhodamine B (RhB) under irradiation with visible light.
On low‐complexity adaptive wireless push‐based data broadcasting
Authors: Polatoglou Marianna , Nicopolitidis Petros , Papadimitriou Georgios I. 
Published: April 2012

SUMMARYThis letter addresses a low‐complexity adaptive wireless data broadcasting system. Specifically, it proposes a way for reducing the computational complexity of the estimation process for the item demands, which in turn leads to a lower computational complexity to the broadcast server for selecting a data item to broadcast. We assume no a priori knowledge of the client demands for information items as happens in real environments. Simulation results reveal that the lowering of the computational complexity of the proposed system does not affect the performance offered to the system clients. Copyright © 2012 John Wiley & Sons, Ltd.
Adaptive anomaly control for alleviating the exclusive channel occupation in wireless networks
Authors: Park Hyunhee , Shon Taeshik , Park Seunghyun , Kim Eui‐Jik 
Published: April 2012

SUMMARYIn wireless local area networks, interframe space is determined according to the type of transmission frame in order to perform effective transmission and collision avoidance using carrier sense multiple access/collision avoidance (CSMA/CA) mechanism and to attempt transmission after backoff time. In carrier sense multiple access/collision avoidance mechanism, however, each node individually determines the interframe space according to the transmission frames and randomly selects the backoff time; thus, the nodes can be selfish, which reduces the interframe space or backoff time in order to increase the channel occupation rate. This increase leads to an increase in bandwidth in channels dominated by such selfish nodes and a decrease in bandwidth of other nodes. After all, to prevent exclusive channel occupation and to guarantee fair channel access, it is necessary to establish detection and control schemes for selfish nodes. We propose misbehavior detection and control scheme for use in media access control layers, which involves comparison of the channel occupation rates of all nodes and a selective control scheme using a network allocation vector clearing method. We also validate the misbehavior detection and control scheme through extensive simulation. Copyright © 2012 John Wiley & Sons, Ltd.
Induction of the chick columella and its integration with the inner ear
Authors: Zou Yihui , Mak Siu‐Shan , Liu Hui Zhan , Han Dong Yi , Zhuang Hong Xing , Yang Shi Ming , Ladher Raj K. 
Published: April 2012

AbstractBackground: The auditory complex of the chick, like that of humans, is made of intimate and highly ordered connections between the inner ear, the middle ear, and the outer ear. Unlike mammals, the middle ear of chick has only one ossicle, known as the columella. The independent lineages of the two suggest that some mechanism must exist that ensures the connectivity between the inner ear and the columella; however, the basis of integration is not known. Results: Using quail‐chick chimeras, we demonstrate that columella development depends on signaling interactions. Specifically, both pharyngeal endoderm and cranial paraxial mesoderm can alter the morphology of the columella. Only a discrete region of pharyngeal endoderm exerts this patterning activity, and this region is specified by the overlying paraxial mesoderm. Conclusions: Paraxial mesoderm is also used in the induction of the inner ear, thus we propose that this overlapping source of signalling cues in both middle and inner ear development may underlie the integration of these structures. Developmental Dynamics 241:1104–1110, 2012. © 2012 Wiley Periodicals, Inc.
Conditional expression of Lodavin, an avidin‐tagged LDL receptor, for biotin‐mediated applications in vivo
Authors: Murugan Subramanian , Saarela Ulla , Airenne Kari , Shan Jingdong , Skovorodkin Ilya , Ylä‐Herttuala Seppo , Vainio Seppo J. 
Published: April 2012

AbstractLodavin represents an engineered fusion protein that consists of a cytoplasmic and a transmembrane domain of the human low‐density lipoprotein receptor coupled to an extracellular avidin monomer. Biotinylated compounds have been successfully targeted to Lodavin‐expressing cells that have been transduced by a Lodavin‐containing virus, and the targeting is based on the high affinity between biotin and avidin. We engineered a Rosa26 (R26R) knock‐in Lodavin mouse to develop biotin‐based applications such as targeted drug delivery, cell purification, and tissue imaging in vivo. A cDNA encoding Lodavin was inserted downstream of a floxed βgeo resistance gene in the R26R locus in embryonic stem cells, and a germ line‐derived R26RLodavin mouse line was generated. Efficient removal of the floxed βgeo cassette and conditional activation of Lodavin expression was achieved as a result of crossing the R26RLodavin mice with HoxB7‐Cre, Wnt4‐Cre, or Tie1‐Cre mice. In summary, the R26RLodavin mouse line may provide a useful tool for testing and developing applications with the aid of avidin and biotin interaction. genesis 50:693–699, 2012. © 2012 Wiley Periodicals, Inc.
Emotion and eating disorder symptoms in patients with anorexia nervosa: An experimental study
Authors: Wildes Jennifer E. , Marcus Marsha D. , Bright Ashley C. , Dapelo Marcela Marin , Psychol Magister Clin 
Published: April 2012

AbstractObjective:To evaluate the effect of negative emotion on self‐reported eating disorder symptoms and objectively‐measured eating behavior in patients with anorexia nervosa (AN).Method:Twenty‐eight females with AN were randomized to a negative or neutral mood induction followed by a test meal. Participants completed assessments one week before the experimental session, before (pretest) and after (posttest) the mood induction, and after the test meal.Results:Participants in the negative emotion condition had an increase in negative affect from pretest to posttest that was accompanied by significantly greater increases in self‐reported eating disorder symptoms than were exhibited by participants in the neutral emotion condition, who had no increase in negative affect. There was no effect of emotion condition on eating behavior.Discussion:Results suggest that negative emotions influence the expression of cognitive eating disorder symptoms in individuals with AN, which may have implications for the identification of treatment targets. © 2012 by Wiley Periodicals, Inc. (Int J Eat Disord 2012;45:876–882)
Rastlos in einer sesshaften Welt
Authors: Unterstell Rembert 
Published: April 2012

AbstractNomaden in Geschichte und Gegenwart: Die Ausstellung „Brisante Begegnungen”︁ im Hamburger Museum für Völkerkunde stößt Fenster zu einer Vielfalt von Lebenswelten auf. Besuch eines Denkortes, der Ergebnisse eines DFG‐Sonderforschungsbereichs präsentiert.
Schneller, präziser, sichtbarer
Authors: Greve Henry , Jahns Robert , Raethjen Jan 
Published: April 2012

AbstractEKG und EEG stoßen immer wieder an ihre Grenzen. Für neuartige Magnetfeldsensoren suchen Physiker, Elektrotechniker und Mediziner nun nach optimalen Verbundwerkstoffen. Diagnose und Behandlung von Herz‐ und Hirnerkrankungen könnten davon profitieren.
Von der Idee zur Erkenntnis — sichtbar gemacht
Authors: Kleiner Matthias 
Published: April 2012

AbstractWenn von Wissenschaft die Rede ist, geht es oft um ihre Finanzierung und Organisation. Allzu leicht vergessen wird dabei aber das Wichtigste: Themen, Inhalte und Ergebnisse. Wissenschaftsförderung heißt daher auch, ihre Potenziale und Erfolge öffentlich darzustellen.
Retracted: Human factors of knowledge‐sharing intention among taiwanese enterprises: A model of hypotheses
Authors: Chen Cheng‐Wu , Chang Min‐Li , Tseng Chun‐Pin 
Published: April 2012

AbstractKnowledge management (KM) is very important in the business world of today. The Taiwanese government has recognized the importance of KM in helping small and medium enterprises (SMEs) to innovate through both their internal core competencies and external resources. This study combines the concept of social capital and motivation–opportunity–ability models by both social and technological dimensions to investigate the human factors that characterize knowledge sharing and the motivational elements that can encourage investment in it. In addition, this study also proposes some possible perspective suggestions for implementing KM initiatives to reinvigorate Taiwanese SMEs. © 2012 Wiley Periodicals, Inc.
Semiautomated Identification and Classification of Customer Complaints
Authors: Choe Pilsung , Lehto Mark R. , Shin Geon‐Cheol , Choi Kyu‐Yeong 
Published: April 2012

AbstractThis paper examines the feasibility of extracting useful information from customer comments using a Naïve Bayes classifier. This was done for a database, obtained from a large Korean mobile telephone service provider, of 533 customer calls to call centers in 2009. After eliminating calls not containing customer complaints or comments, the remaining 383 comments were classified by an expert panel into four domains and 27 complaint categories. The four domains were Transaction‐related (189 comments, 49%), Product‐related (120 comments, 31%), Customer Service or Support‐related (38 comments, 10%) and Customer Outreach and Marketing‐related (36 comments, 9%). The comments were then randomly assigned to either a training set (257 cases, 67%) or test set (126 cases, 33%). The training set was used to develop a Naïve Bayes classifier that correctly predicted the domain 75% of the time and the specific subcategory 51% of the time for the test set. Prediction accuracy was strongly related to prediction strength for both sets of predictions, suggesting that simple filtering strategies where difficult to understand comments are flagged for expert review and easy comments are automatically classified are both technically feasible and likely to be practically valuable. Several strong predictors were also identified that corresponded to categories more detailed than those originally assigned. © 2012 Wiley Periodicals, Inc.
Distinct contributions of human hippocampal theta to spatial cognition and anxiety
Authors: Cornwell Brian R. , Arkin Nicole , Overstreet Cassie , Carver Frederick W. , Grillon Christian 
Published: April 2012

AbstractCurrent views of the hippocampus assign this structure, and its prominent theta rhythms, a key role in both cognition and affect. We studied this duality of function in humans, where no direct evidence exists. Whole‐head magnetoencephalographic (MEG) data were recorded to measure theta activity while healthy participants (N = 25) navigated two virtual Morris water mazes, one in which they risked receiving aversive shocks without warning to induce anxiety and one in which they were safe from shocks. Results showed that threat of shock elevated anxiety level and enhanced navigation performance as compared to the safe condition. MEG source analyses revealed that improved navigation performance during threat was preferentially associated with increased left septal (posterior) hippocampal theta (specifically 4–8 Hz activity), replicating previous research that emphasizes a predominant role of the septal third of the hippocampus in spatial cognition. Moreover, increased self‐reported anxiety during threat was preferentially associated with increased left temporal (anterior) hippocampal theta (specifically 2–6 Hz activity), consistent with this region's involvement in mediating conditioned and innate fear. Supporting contemporary theory, these findings highlight simultaneous involvement of the human hippocampus in spatial cognition and anxiety, and clarify their distinct correlates. © 2012 Wiley Periodicals, Inc.
Effectiveness of two formulations of oral olanzapine in patients with schizophrenia or bipolar disorder in a natural setting: results from a 1‐year European observational study
Authors: Kraemer Susanne , Chartier Florence , Augendre‐Ferrante Béatrice , Psarra Vassiliki , D'yachkova Yulia , Beselin Anke , Rouillon Fréderic 
Published: April 2012

ObjectiveThis study aims to assess the proportion of patients with schizophrenia or bipolar disorder who discontinued treatment with one of two oral formulations of olanzapine within 12 months in outpatient settings in Germany, Greece, and France.MethodsThis 1‐year, prospective, observational study included patients who had recently initiated treatment with olanzapine‐coated tablets (OC) or the orodispersible (OD) formulation. Primary endpoint was olanzapine discontinuation for any reason. Clinical and functional status were also evaluated.ResultsOut of 927 enrolled patients, 903 were included in the analyses (612 patients with schizophrenia, 291 with bipolar disorder). Within 12 months, 46 of 903 patients discontinued olanzapine. Most (95%) patients remained on olanzapine for 12 months with similar rates for patients with either diagnosis (94.5% for schizophrenia, 94.9% for bipolar disorder) and for both formulations (93.7% with OC, 95.3% with OD). The only factor significantly associated with time to discontinuation was baseline disease severity. Patients with more severe disease at baseline had a lower discontinuation risk. There were significant improvements in functioning and well‐being and non‐significant improvements in therapeutic alliance and compliance.ConclusionsNo significant difference was seen between discontinuation rates of the two formulations. Higher baseline severity was associated with a lower discontinuation rate. Copyright © 2012 John Wiley & Sons, Ltd.