bluuebunny/crossref_metadata_2025_split huggingface dataset:
Drink…then drive away: The effects of lowering the blood alcohol concentration in Utah
Authors: Portillo Javier E. , Sugiarto Wisnu , Willardsen Kevin 
Published: May 2024

AbstractIn March of 2017 Utah announced its intent to lower the legal blood alcohol content (BAC) for driving from 0.08 to 0.05 g/dL. However, this change did not take effect until 2019. We employ a difference‐in‐ differences strategy on Utah counties using neighboring states as controls to test whether this policy change significantly affected the number of traffic accidents or the severity of those accidents. Results show the policy appears to temporarily decrease the total number of accidents, limited primarily to property damage‐ only accidents. We believe these results may be partially explained by drivers who, after the policy is enacted, avoid reporting property damage‐only accidents if possible. Using insurance claims data, we show there is no corresponding fall in insurance claims or payouts suggesting that the fall in total accidents likely comes from under‐reporting.
FLT3‐ITD regulation of the endoplasmic reticulum functions in acute myeloid leukemia
Authors: Turos‐Cabal María , Sánchez‐Sánchez Ana M. , Puente‐Moncada Noelia , Herrera Federico , Antolin Isaac , Rodríguez Carmen , Martín Vanesa 
Published: May 2024

AbstractThe FLT3‐ITD mutation represents the most frequent genetic alteration in newly diagnosed acute myeloid leukemia (AML) patient and is associated with poor prognosis. Mutation result in the retention of a constitutively active form of this receptor in the endoplasmic reticulum (ER) and the subsequent modification of its downstream effectors. Here, we assessed the impact of such retention on ER homeostasis and found that mutant cells present lower levels of ER stress due to the overexpression of ERO1α, one of the main proteins of the protein folding machinery at the ER. Overexpression of ERO1α resulted essential for ITD mutant cells survival and chemoresistance and also played a crucial role in shaping the type of glucose metabolism in AML cells, being the mitochondrial pathway the predominant one in those with a higher ER stress (non‐mutated cells) and the glycolytic pathway the predominant one in those with lower ER stress (mutated cells). Our data indicate that FLT3 mutational status dictates the route for glucose metabolism in an ERO1α depending on manner and this provides a survival advantage to tumors carrying these ITD mutations.
Enhancing educational technology practical course: Designing and validating tools for evaluating knowledge, performance, and satisfaction of public health students
Authors: Darabi Fatemeh , Karimian Zahra 
Published: May 2024

AbstractBackgroundThe present study was conducted with the aim of designing and validating questionnaires for evaluating the public health students' knowledge, performance, and satisfaction (KPS) in the course of educational technology.MethodsThe present study was conducted with qualitative‐quantitative approach. Qualitative stage was done based on experts' opinion and related articles and questionnaires for developing, designing, and validating the tools. For validating the tools, face validity and content validity was done based on the opinion of the 10 expert panel. In quantitative stage, all initial validated tools were implemented on 50 students of public health for determining the reliability. The reliability of the tools was calculated using the internal consistency method of the items with Cronbach's ⍺ coefficient, and Kuder–Richardson. All analyses were conducted using SPSS‐19 software.ResultsIn the field of qualitative research, an assessment tool consisting of 20 four‐option questions was designed. The content validity of this tool was confirmed based on the opinions of 10 educational experts, with CVI Total = 0.862 and CVR = 0.885. Additionally, the reliability of the tool was validated through testing on 50 public health students, resulting in a reliability coefficient of r = 0.780. Furthermore, for performance evaluation, four assessment tools each comprising 20 questions (totaling 80 questions) were designed. The validity values for these tools in the areas of PowerPoint (CVI = 0.981, CVR = 0.960), pamphlet (CVI = 0.866, CVR = 0.877), poster (CVI = 0.871, CVR = 0.906), role‐playing (CVI = 0.871, CVR = 0.980), and the reliability of the tools with Cronbach's ⍺ r > 0.80 were confirmed. In the satisfaction assessment section, a researcher‐made questionnaire consisting of 18 questions across seven domains was designed, with confirmed content validity (CVI = 0.949, CVR = 0.861) and reliability (r = 0.928).ConclusionsIt seems that this tool can be used to measure the KPS of students from the educational technology course of the health field and similar fields.
Sensing of luminal contents and downstream modulation of GI function
Authors: Dontamsetti Kiran Devi , Pedrosa‐Suarez Laura Camila , Aktar Rubina , Peiris Madusha 
Published: May 2024

AbstractThe luminal environment is rich in macronutrients coming from our diet and resident microbial populations including their metabolites. Together, they have the capacity to modulate unique cell surface receptors, known as G‐protein coupled receptors (GPCRs). Along the entire length of the gut epithelium, enteroendocrine cells express GPCRs to interact with luminal contents, such as GPR93 and the calcium sensing receptor to sense proteins, FFA2 and GPR84 to sense fatty acids, and SGLT1 and T1R to sense carbohydrates. Nutrient–receptor interaction causes the release of hormonal stores such as glucagon‐like peptide 1, peptide YY, and cholecystokinin, which further regulate gut function. Existing data show the role of luminal components and microbial fermentation products on gut function. However, there is a lack of understanding in the mechanistic interactions between diet‐derived luminal components and microbial products and nutrient‐sensing receptors and downstream gastrointestinal modulation. This review summarizes current knowledge on various luminal components and describes in detail the range of nutrients and metabolites and their interaction with nutrient receptors in the gut epithelium and the emerging impact on immune cells.
Heterogeneity of brain extracellular matrix and astrocyte activation
Authors: Huber Rebecca E. , Babbitt Courtney , Peyton Shelly R. 
Published: May 2024

AbstractFrom the blood brain barrier to the synaptic space, astrocytes provide structural, metabolic, ionic, and extracellular matrix (ECM) support across the brain. Astrocytes include a vast array of subtypes, their phenotypes and functions varying both regionally and temporally. Astrocytes' metabolic and regulatory functions poise them to be quick and sensitive responders to injury and disease in the brain as revealed by single cell sequencing. Far less is known about the influence of the local healthy and aging microenvironments on these astrocyte activation states. In this forward‐looking review, we describe the known relationship between astrocytes and their local microenvironment, the remodeling of the microenvironment during disease and injury, and postulate how they may drive astrocyte activation. We suggest technology development to better understand the dynamic diversity of astrocyte activation states, and how basal and activation states depend on the ECM microenvironment. A deeper understanding of astrocyte response to stimuli in ECM‐specific contexts (brain region, age, and sex of individual), paves the way to revolutionize how the field considers astrocyte‐ECM interactions in brain injury and disease and opens routes to return astrocytes to a healthy quiescent state.
Association Between the Creative Experience of Haiku Poetry and a Tendency Toward Self‐Transcendent Emotions
Authors: Kato Juri , Hitsuwari Jimpei 
Published: May 2024

ABSTRACTHaiku is the world's shortest form of poetry, describing nature and ordinary everyday life. Previous studies and quotes from professional haiku poets suggest that haiku can foster self‐transcendent emotions, such as gratitude and awe. This study compares how those who did and did not create at least one haiku in the past month experience self‐transcendent emotions. A total of 192 haiku writers and 177 non‐writers responded to scales related to self‐transcendent emotions, such as gratitude for serenity, gratitude trait, and trait awe. The results of the Bayesian implementation of Generalized Linear Mixed models revealed that haiku writing increased the frequency of gratitude for serenity and awe, rather than general gratitude. These effects persisted even after controlling for interest in art and educational level, indicating that haiku writing has unique characteristics, including encouragement of attention to nature and a different perspective on daily life. Even in the absence of special events, a change in perspective toward everyday life occurs through creating haiku, and people appreciate and feel awe toward ordinary, everyday things. These novel findings contribute to the study of creativity and emotion.
Advocacy in pediatric gastroenterology: An academic clinician's impact and guide
Authors: Abbas Mazen I. , Kohli Rohit , Du Nan , Orsagh‐Yentis Danielle K. , Dotson Jennifer L. 
Published: May 2024

AbstractThe current state of policy‐making necessitates clinicians and their organizations to be more engaged. This article provides practical examples of how to engage in various levels of advocacy within pediatric gastroenterology.
Prevention of venous thromboembolism after total hip and knee arthroplasties in Australian hospitals: what are we using?
Authors: van Oosterom Nameer , Barras Michael , Cottrell Neil 
Published: May 2024

AbstractBackgroundVenous thromboembolism (VTE) is a leading cause of preventable morbidity and mortality, with total hip arthroplasty (THA) and total knee arthroplasty (TKA) at the highest risk. Safe and appropriate thromboprophylaxis is essential. However, investigations into prescribing practices have been limited.AimTo describe current VTE prophylaxis regimens in Australian patients following an elective THA/TKA and compare these regimens to an international standard.MethodA retrospective multisite case series of patients admitted for a THA/TKA in six tertiary hospitals in Queensland, Australia, was conducted over 12 months (1 October 2017–30 September 2018). Patient and medication data were collected following surgery and for 60 days after discharge to determine changes to the patients' thromboprophylaxis regimen. Results were summarised and compared to National Institute for Health and Care Excellence (NICE) guidelines. Ethical approval was granted by the Metro South Human Research Ethics Committee (Reference no: HREC/2018/QMD/46757) and the study conforms to the National Statement on Ethical Conduct in Human Research.ResultsThe study included 1011 patients (43.1% THA, 56.9% TKA), and thromboprophylaxis was used in 98.1% of inpatients and in 94.3% of discharge patients for 5.2 (±5.2) and 29.2 (±15.9) days (±standard deviation) respectively. Low‐molecular‐weight heparins (LMWHs) were the primary drugs for inpatients (71.2%) and aspirin 150 mg for discharge (42.0%), most commonly for 6 weeks (31.8%). Aspirin was used for significantly longer duration than rivaroxaban and LMWH (p < 0.001). A two‐staged prophylaxis regimen was implemented, most commonly any anticoagulant as an inpatient; followed by rivaroxaban on discharge (32.7%) or an anticoagulant as an inpatient with aspirin on discharge (26.4%). Overall, adherence to NICE guidelines was low; THA: 8.7%, TKA: 5.9%.ConclusionVTE prophylaxis regimens varied considerably, and consequently, adherence to international guidelines was low. There is a need for local, peer‐led guidelines to ensure consistent, safe, and effective prophylaxis.
Differentiation of pine and oil‐based soots in East Asian inks using Raman spectroscopy
Authors: Giaccai Jennifer , Miller J. Houston 
Published: May 2024

AbstractEast Asian inks are a major component of calligraphy, paintings, and prints in China, Japan, and Korea and are historically made from either pine soot or oil‐lamp soot mixed with a proteinaceous binder. Although the inks from the two different soot sources have different properties in East Asian works of art, no non‐destructive methods to differentiate them scientifically currently exist. Raman spectroscopy (RS) of carbonaceous materials is commonly used to extract information about their properties and has been applied here to East Asian inks. Soots used in making modern inks were collected from 10 sources in China and Japan and analyzed using RS. RS using 405‐, 633‐, and 785‐nm excitation has been able to differentiate pine soot from oil‐lamp soot, also called lampblack. In addition, principal component analysis (PCA) of only 785‐nm Raman spectra has been able to discriminate between two different soots used in a 19th‐century Japanese woodblock printing of Kaishien Gaden. In addition to allowing discrimination between inks on East Asian works of art, these results may be of use to other fields using carbonaceous materials.
Microfluidics identify moso bamboo and henon bamboo by leaf protoplast subpopulations with single‐cell analysis
Authors: Liu Yameng , Wang Mingxu , Wang Xiaohu 
Published: May 2024

Current techniques identifying herbal medicine species require marker labeling or lack systematical accuracy (expert authentication). There is an emerging interest in developing an accurate and label‐free tool for herbal medicine authentication. Here, a high‐resolution microfluidic‐based method is developed for identifying herbal species by protoplast subpopulations. Moso bamboo and henon bamboo are used as a model to be differentiated based on protoplast. Their biophysical properties factors are characterized to be 7.09 (± 0.39) × 108 V/m2 and 6.54 (± 0.26) × 108 V/m2, respectively. Their biophysical distributions could be distinguished by the Cramér–von Mises criterion with a 94.60% confidence level. The subpopulations of each were compared with conventional flow cytometry indicating the existence of subpopulations and the differences between the two species. The subsets divided by a biophysical factor of 8.05(± 0.51) × 108 V/m2 suggest good consistency with flow cytometry. The work demonstrated the possibility of microfluidics manipulation on protoplast for medication safety use taking advantage of dielectrophoresis. The device is promising in developing a reliable and accurate way of identifying herbal species with difficulties in authentication.
Esophageal Baseline Impedance is Associated with Laryngopharyngeal Reflux and Treatment Response
Authors: Kurylo Christopher M. , Noel Jacob , Blumin Joel H. , Bock Jonathan M. 
Published: May 2024

ObjectiveTo evaluate the efficacy of distal esophageal mean nocturnal baseline impedance (MNBI), a general marker of esophageal mucosal barrier integrity, in predicting laryngopharyngeal reflux (LPR) and symptomatic response to acid reflux therapy.MethodsThis retrospective study analyzed 173 patients who presented with symptoms of laryngopharyngeal reflux and underwent 24‐h multichannel intraluminal impedance‐pH (MII‐pH) testing. Mean nocturnal baseline impedance values were calculated and assessed for their association and ability to predict LPR symptoms, MII‐pH results, treatment response, and other markers of LPR.ResultsNotably, 153 of the 173 patients were tested off acid suppression medication and included in statistical analysis. Based on the MII‐pH probe data, 108 (71%) patients had LPR, 8 (5%) had gastroesophageal reflux disease (GERD), and 37 (24%) were without pathologic reflux. Distal esophageal MNBI of LPR patients was significantly lower in LPR patients than patients with negative studies (1332 ± 94.8 vs. 2158 ± 173.5, p = 0.001). Among 118 patients who trialed antireflux therapy, a distal esophageal MNBI cutoff value of <1580 Ω was an independent predictor of treatment response (OR = 4.148 [1.877–9.189]). This value better predicted improvement with antireflux therapy for LPR than other objective MII‐pH probe data, which were not independent predictors of treatment response.ConclusionDistal esophageal MNBI values may have value in the diagnosis of LPR and potentially predict medication responsiveness in LPR patients.Level of Evidence3 Laryngoscope, 134:4071–4077, 2024
Soil erosion associated with roads—A global review and statistical analysis
Authors: Yu Zaihui , Zhao Qinghe , Liu Yi , Yu Jinhai , Wang An , Ding Shengyan 
Published: May 2024

AbstractGlobal soil degradation due to road erosion is an escalating concern. This study employed bibliometric analysis using the Science Citation Index‐Expanded dataset to gain insights into research trends in road erosion. It covered the years 2000–2021, revealing a steady increase in annual research publications, particularly after 2018. The United States and Catena was the leading contributor and the most popular journal, respectively. The primary research areas identified by keywords and statistical analysis are the forests and arid regions in the temperate climate zone (including temperate continental climate and temperate monsoon climate) and the tropical climate zone (including tropical rainforest climate and tropical monsoon climate). Since 2012, a noticeable shift from traditional methods to emerging technologies like isotope tracing (e.g., 137Cs, 210Pb) and machine learning (e.g., random forest) was observed, indicating evolving in methodologies with changes in research scales. The study emphasized the inevitability of road erosion, highlighting the crucial role of effective road management and restoration. It proposed integrating best management practices and ecosystem restoration strategies into watershed management, combined with advanced technological approaches, to foster sustainable watershed development.
Lab on a Secchi disk: A prototype open‐source profiling package for low‐cost monitoring in aquatic environments
Authors: Brewin Robert J. W. , Brewin Thomas G. , Bresnahan Philip J. , Davis Keiley , Sun Xuerong , Wilson Nicola , Brunner Lars , Dall'Olmo Giorgio 
Published: May 2024

AbstractOwing to the high cost of commercial optical sensors, there is a need to develop low‐cost optical sensing packages to expand monitoring of aquatic environments, particularly in under‐resourced regions. Visual methods to monitor the optical properties of water, like the Secchi disk and Forel‐Ule color scale, remain in use in the modern era owing to their simplicity, low‐cost and long history of use. Yet, recent years have seen advances in low‐cost, electronic‐based optical sensing. Here, the designs of a miniaturized hand‐held device (mini‐Secchi disk) that measures the Secchi depth and Forel‐Ule color are updated. We then extend the device by integrating a small electronic sensing package (Arduino‐based) into the Secchi disk, for vertical profiling, combining historic and modern methods for monitoring the optical properties of water into a single, low‐cost sensing device, that measures positioning (GPS), light spectra, temperature, and pressure. It is charged and transfers data wirelessly, is encased in epoxy resin, and can be used to derive vertical profiles of spectral light attenuation and temperature, in addition to Secchi depth and Forel‐Ule color. We present data from a series of deployments of the package, compare its performance with commercially available instruments, and demonstrate its use for validation of satellite remotely sensed data. Our designs are made openly available to promote community‐based development and have potential in communicating and teaching science, participatory science, and low‐cost monitoring of aquatic environments.
Limited‐time pricing strategy considering consumer regret under channel competition
Authors: Yu Shiqiang , Guo Chunxiang , Cheng Hongling , Wu Meng 
Published: May 2024

AbstractThis study constructs a pricing strategy model that considers consumer busyness and low price duration to examine the effectiveness of limited‐time pricing in influencing consumer behavior. The results show that local store can develop a limited‐time promotion strategy to improve profit, and there is an optimal low price duration. As consumer busyness increases, online retailer's profit may decrease, as local store is better able to leverage consumer busyness to enhance competitiveness. Interestingly, when local store lower price, online retailer may actually need to increase price to obtain greater profit from consumers who missed out on store discounts.
A Concise Synthesis of (−)‐Ambrox
Authors: Wang Bingyang , Liu Yanhui , Jia Chenyang , Lan Zhenfang , Yang Xuepeng 
Published: May 2024

Abstract(−)‐Ambrox, a highly prized and commercially significant component of ambergris, finds widespread application in perfumery, cigarettes, cosmetics, and the food industry. Despite considerable attention to this research area over the years, an environmentally friendly and practical method for synthesizing (−)‐ambrox has remained elusive. This study presents a succinct and efficient approach to (−)‐ambrox synthesis, involving two consecutive alkylations at C‐6, followed by an acid‐catalyzed cyclization to give bicyclic ketones starting from (R)‐carvone. Subsequent reduction, Barton Vinyl Iodide synthesis, alkylation, and an acid‐catalyzed cyclization collectively achieved the synthesis of (−)‐ambrox with a satisfactory yield of 26.2 %.
Moving beyond gross domestic product: The impacts of gross domestic product‐centric cadre performance targets shift on environmental protection
Authors: Zeng Jingjing , Bao Rui 
Published: May 2024

AbstractThe impacts of the economic matrix, particularly the Gross Domestic Product (GDP), within the cadre performance target system (CPTS) on the trade‐offs between local environment and economy have been extensively researched. However, few studies have adequately considered the transition from a single‐target to a multi‐target system and the effects of dynamic changes in this system. This study addresses this gap by assessing the causal effects of China's historic adjustment of GDP‐centric CPTS on local environmental quality. By introducing a dynamic analytical framework of CPTS and employing a time‐varying Difference‐in‐Differences (DiD) design with county‐level data from 2009 to 2018, this study reveals two key findings: (1) Counties that shifted away from a GDP‐centric performance target system experienced a significant average reduction in PM2.5 pollution levels by 6.6%, highlighting the environmental benefits of moving beyond GDP‐focused CPTS; (2) The observed environmental improvements are driven by two mechanisms—correcting land misallocation and optimizing industrial structure. This study advances previous static and single‐goal analyses by introducing a dynamic, multi‐target perspective to cadre performance target‐setting.