bluuebunny/crossref_metadata_2025_split huggingface dataset:
Synthesis, characterization, physicochemical, and electrical properties of natural (bio) nanofluids
Authors: Awua J. T. , Ibrahim J. S. , Krishnan Suseel Jai , Edeoja A. O. , Kuhe A. , Sharifpur M. , Murshed S. M. S. 
Published: May 2024

AbstractEnergy conservation and sustainability to reduce the dependence on conventional sources have resulted in modified or advanced process practices. One such is the use of nanofluids for enhanced energy efficiency. However, such practices must not be at the cost of environmental hazards. The current study emphasizes bio‐based nanofluids formulated at five different volumetric concentrations (0.2%, 0.4%, 0.6%, 0.8%, and 1.0%) using Flamboyant (Royal Poinciana) tree bark nanoparticles with ethylene glycol as base fluid. The nanoparticles synthesized by cost‐effective extensive ball milling technique were spherical in shape. Analyzing the nanofluid with TEM confirms the particles as evenly distributed with an average diameter of 26 nm. Elemental analysis shows that the bio powder contains oxides of Calcium and Silicon. The pH, electrical conductivity, and viscosity of the prepared flamboyant tree bark‐ethylene glycol (FTB‐EG) nanofluid were quantified between 20 and 70°C. Although the properties enhanced with increase in concentration, the viscosity and pH decreased with temperature rise, while the electrical conductivity behaved contradictory. The maximum and minimum values of the properties were attributed to 1.0% and 0.2% concentrations, respectively. The correlations were proposed and the deviation between the measured and correlation data was less than 10%.
Boosting large‐scale construction project risk management: Application of the impact of building information modeling, knowledge management, and sustainable practices for optimal productivity
Authors: Tabejamaat Sajad , Ahmadi Hassan , Barmayehvar Behnod 
Published: May 2024

AbstractThis study investigates the relationship between Building Information Modeling (BIM) and knowledge management in large‐scale construction projects, emphasizing risk management, and increasing productivity. This study aims to identify the most important and impactful aspects of modern management techniques in the large‐scale construction sector to improve construction quality; focusing on cost reduction, energy conservation, and pollution reduction during construction. Employing a validated questionnaire from experts and the Analytical Hierarchy Process (AHP), the research prioritizes key factors, elucidating the pivotal role of BIM in understanding project geometry, efficient documentation, design flexibility, and reduced project delays. Ascertained through data analysis employing the pairwise comparisons method of the AHP analysis method, the compatibility of all comparisons and matrices arising from the decision‐making process of experts was below 0.1. The results establish BIM's technical capabilities, economic considerations, and pollution reduction as paramount, contributing significantly to improve large‐scale construction project risk management. The prioritization of the main criteria reveals their significance in the following order: BIM technical capabilities (0.281), BIM economic capabilities (0.231), pollution reduction (0.228), knowledge management capabilities (0.096), BIM time capabilities (0.090), and human resources management capabilities (0.074). BIM can improve risk management for large‐scale construction projects by: using the BIM model to understand the geometry and features of large‐scale construction projects; digitizing and organizing contract documents, project data, plans, work instructions, roles and responsibilities, cost, time, and energy analysis, and other project‐related documents for efficient project management; decreased duplication and project delays; reducing the need for on‐site personnel during implementation and CO2 emissions reduction. According to the results of the BIM model utilization to better understand the geometry and characteristics of large‐scale construction projects, the item was identified as the most significant and influential among the main components.
Ecotoxicological Assessment of Microplastics and Cellulose Particles in the Galápagos Islands and Galápagos Penguin Food Web
Authors: McMullen Karly , Calle Paola , Alvarado-Cadena Omar , Kowal Matthew D. , Espinoza Eduardo , Domínguez Gustavo A. , Tirapé Ana , Vargas Félix Hérnán , Grant Edward , Hunt Brian P. V. , Pakhomov Evgeny A. , Alava Juan José 
Published: May 2024

Abstract
Microplastic pollution threatens some of the world's most iconic locations for marine biodiversity, including the remote Galápagos Islands, Ecuador. Using the Galápagos penguin (Spheniscus mendiculus) as a sentinel species, the present study assessed microplastics and suspected anthropogenic cellulose concentrations in surface seawater and zooplankton near Santa Cruz and Galápagos penguin colonies (Floreana, Isabela, Santiago), as well as in penguin potential prey (anchovies, mullets, milkfish) and penguin scat. On average, 0.40 ± 0.32 microplastics L−1 were found in surface seawater (&lt;10 μm; n = 63 L), while 0.003, 0.27, and 5.12 microplastics individual−1 were found in zooplankton (n = 3372), anchovies (n = 11), and mullets (n = 6), respectively. The highest concentration (27 microplastics individual−1) was observed in a single milkfish. Calculations based on microplastics per gram of prey, in a potential diet composition scenario, suggest that the Galápagos penguin may consume 2881 to 9602 microplastics daily from prey. Despite this, no microplastics or cellulose were identified in 3.40 g of guano collected from two penguins. Our study confirms microplastic exposure in the pelagic food web and endangered penguin species within the UNESCO World Heritage site Galápagos Islands, which can be used to inform regional and international policies to mitigate plastic pollution and conserve biodiversity in the global ocean. Environ Toxicol Chem 2024;43:1442–1457. © 2024 The Authors. Environmental Toxicology and Chemistry published by Wiley Periodicals LLC on behalf of SETAC.
Tissue-Specific Distribution and Maternal Transfer of Persistent Organic Halogenated Pollutants in Frogs
Authors: Guan Ke-Lan , Luo Xiao-Jun , Zhu Chu-Hong , Chen Xi , Chen Peng-Peng , Guo Jian , Hu Ke-Qi , Zeng Yan-Hong , Mai Bi-Xian 
Published: May 2024

Abstract
Persistent organic pollutants pose a great threat to amphibian populations, but information on the bioaccumulation of contaminants in amphibians remains scarce. To examine the tissue distribution and maternal transfer of organic halogenated pollutants (OHPs) in frogs, seven types of tissues from black-spotted frog (muscle, liver, kidney, stomach, intestine, heart, and egg) were collected from an e-waste–polluted area in South China. Among the seven frog tissues, median total OHP concentrations of 2.3 to 9.7 μg/g lipid weight were found (in 31 polychlorinated biphenyl [PCB] individuals and 15 polybrominated diphenyl ether [PBDE], dechlorane plus [syn-DP and anti-DP], bexabromobenzene [HBB], polybrominated biphenyl] PBB153 and -209], and decabromodiphenyl ethane [DBDPE] individuals). Sex-specific differences in contaminant concentration and compound compositions were observed among the frog tissues, and eggs had a significantly higher contaminant burden on the whole body of female frogs. In addition, a significant sex difference in the concentration ratios of other tissues to the liver was observed in most tissues except for muscle. These results suggest that egg production may involve the mobilization of other maternal tissues besides muscle, which resulted in the sex-specific distribution. Different parental tissues had similar maternal transfer mechanisms; factors other than lipophilicity (e.g., molecular size and proteinophilic characteristics) could influence the maternal transfer of OHPs in frogs. Environ Toxicol Chem 2024;43:1557–1568. © 2024 SETAC
Taste and its receptors in human physiology: A comprehensive look
Authors: Li Chao , Li Yaxin , Sun Qing , Abdurehim Aliya , Xu Jiawen , Xie Junbo , Zhang Yanqing 
Published: May 2024

AbstractIncreasing evidence shows that food has significance beyond traditional perception (providing nutrition and energy) in maintaining normal life activities. It is indicated that the sense of taste plays a crucial part in regulating human life activities. Taste is one of the basic physiological sensations in mammals, and it is the fundamental guarantee for them to perceive, select, and ingest nutrients in order to survive. With the advances in electrophysiology, molecular biology, and structural biology, studies on the intracellular and extracellular transduction mechanisms of taste have made great progress and gradually revealed the indispensable role of taste receptors in the regulation and maintenance of normal physiological activities. Up to now, how food regulates life activities through the taste pathway remains unclear. Thus, this review comprehensively and systematically summarizes the current study about the sense of taste, the function of taste receptors, the taste–structure relationship of gustatory molecules, the cross‐talking between distinctive tastes, and the role of the gut–organ axis in the realization of taste. Moreover, we also provide forward‐looking perspectives on taste research to afford a scientific basis for revealing the scientific connotation of taste receptors regulating body health.
Improving patient outcomes following vital sign monitoring protocol failure: A retrospective cohort study
Authors: Seitz‐Rasmussen H. E. Sebastian , Føns‐Sønderskov Morten , Kodal Anne‐Marie , Bestle Morten H. 
Published: May 2024

AbstractBackground and AimsVital sign monitoring needs to be timely and correct to recognize deteriorating patients early and trigger the relevant clinical response. The aim of this study is to retrospectively evaluate compliance specifically toward the regional vital sign monitoring protocol the so called early warning score protocol (EWS‐protocol) 72 h before a medical emergency team response (MET‐response) and thereby illuminate whether poor compliance translates into a worse patient outcome.MethodsIt was investigated all eligible patients that underwent MET responses during the calendar year 2019. The inclusion criteria encompassed somatic patients above 18 years of age admitted to the hospital and detailed evaluations of the medical records of the included patients were conducted.ResultsFour hundred and twenty‐nine MET‐responses were included in the final analysis. EWS‐protocol failure was observed for more than half the patients within all the time frames assessed. Thirty‐day mortality was significantly higher for patients subject to EWS protocol failure in the timeframes 24−16, 16−8, 8−0 h before MET response. Adjusting for admission length, age, and gender, patients subject to EWS‐protocol failure had an odds ratio (OR) of 1.9, 2.0, 2.1, 2.3 for mortality in the time frames 72−48, 24−16, 16−8, and 8−0 h before the MET‐response, respectively. The adjusted OR for ICU‐admission was 1.7, and 1.6 for patients subject to EWS‐protocol failure in the time frames 16−8 and 8−0 h before MET‐response, respectively.ConclusionAccording to all the data analysis in this article, there is evidence that compliance toward the NEWS‐protocol is poor. EWS‐protocol failure is associated with a significant higher mortality and ICU‐admission rate.
Molecular detection of Class 1, 2, and 3 integrons in hypervirulent and classic Klebsiella pneumoniae isolates: A cross‐sectional study
Authors: Farajzadeh Sheikh Ahmad , Abdi Marjan , Farshadzadeh Zahra 
Published: May 2024

AbstractBackground and AimsThe “hypervirulent” variant of Klebsiella pneumoniae (hvKp) is an emerging pathogen that cause life‐threatening infection. The present study was conducted to identify the prevalence of hvKp and to investigate the presence class 1, 2, and 3 integrons in these isolates.MethodsA cross‐sectional study was conducted at three teaching hospitals, Ahvaz, South‐west of Iran, from January 1, 2019 to December 31, 2020. Samples were collected from inpatients and included only the first samples collected from each patient. K. pneumoniae strains were isolated from different specimens using biochemical test and confirmed by targeting 16S–23S rDNA internal transcribed spacer. HvKp isolates were recovered using string test and were further characterized by detection virulence‐associated genes (rmpA, iucA, and magA). Antibiotic susceptibility patterns of isolates were determined using the disc diffusion method. Isolates were screened for presence the integron genes (intI, intII, and intIII) and repetitive element sequence‐based polymerase chain reaction (PCR) performed to determine strain relatedness. SPSS version 22 was used for the data analysis.ResultsSeventy‐one (77%) of isolates showed multidrug‐resistant (MDR) phenotype. HvKP accounted for 14% (13/92) of cKp isolated from blood (46%) and urinary tract infection (38%), and the great majority of them (61.5%; 8/13) exhibited MDR phenotype. Using the PCR assay, 29 of 92 isolates (31.5%) were found to have positive results for the presence of IntI. Three of the IntI‐positive strains were hvKP. Class 2 integron was present in 8/92 cKp isolates. Integron Class 2 was found to coexist with Class 1 integron in 3/8 isolates. All integron‐positive isolates (IntI and/or IntII) were resistant to at least three different classes of antibiotics and showed MDR phenotype. No Class 3 integrons were detected among the isolates.ConclusionThe results of our study revealed that considering the role of integrons in facilitating the acquisition and dissemination of resistance genes among bacteria, monitoring the emergence of hvKp, emphasizing on the mechanism of antimicrobial resistance, can prevent from the spread of carbapenemase‐producing hvKp strains.
Post‐diagnosis adiposity and colorectal cancer prognosis: A Global Cancer Update Programme (CUP Global) systematic literature review and meta‐analysis
Authors: Becerra‐Tomás Nerea , Markozannes Georgios , Cariolou Margarita , Balducci Katia , Vieira Rita , Kiss Sonia , Aune Dagfinn , Greenwood Darren C. , Dossus Laure , Copson Ellen , Renehan Andrew G. , Bours Martijn , Demark‐Wahnefried Wendy , Hudson Melissa M. , May Anne M. , Odedina Folakemi T. , Skinner Roderick , Steindorf Karen , Tjønneland Anne , Velikova Galina , Baskin Monica L. , Chowdhury Rajiv , Hill Lynette , Lewis Sarah J. , Seidell Jaap , Weijenberg Matty P. , Krebs John , Cross Amanda J. , Tsilidis Konstantinos K. , Chan Doris S. M. 
Published: May 2024

AbstractThe adiposity influence on colorectal cancer prognosis remains poorly characterised. We performed a systematic review and meta‐analysis on post‐diagnosis adiposity measures (body mass index [BMI], waist circumference, waist‐to‐hip ratio, weight) or their changes and colorectal cancer outcomes. PubMed and Embase were searched through 28 February 2022. Random‐effects meta‐analyses were conducted when at least three studies had sufficient information. The quality of evidence was interpreted and graded by the Global Cancer Update Programme (CUP Global) independent Expert Committee on Cancer Survivorship and Expert Panel. We reviewed 124 observational studies (85 publications). Meta‐analyses were possible for BMI and all‐cause mortality, colorectal cancer‐specific mortality, and cancer recurrence/disease‐free survival. Non‐linear meta‐analysis indicated a reverse J‐shaped association between BMI and colorectal cancer outcomes (nadir at BMI 28 kg/m2). The highest risk, relative to the nadir, was observed at both ends of the BMI distribution (18 and 38 kg/m2), namely 60% and 23% higher risk for all‐cause mortality; 95% and 26% for colorectal cancer‐specific mortality; and 37% and 24% for cancer recurrence/disease‐free survival, respectively. The higher risk with low BMI was attenuated in secondary analyses of RCTs (compared to cohort studies), among studies with longer follow‐up, and in women suggesting potential methodological limitations and/or altered physiological state. Descriptively synthesised studies on other adiposity‐outcome associations of interest were limited in number and methodological quality. All the associations were graded as limited (likelihood of causality: no conclusion) due to potential methodological limitations (reverse causation, confounding, selection bias). Additional well‐designed observational studies and interventional trials are needed to provide further clarification.
Relationships between emotion regulation strategies and executive functions in adolescence: Exploring the effects of discrete emotions and age
Authors: Fombouchet Yoann , Lannegrand Lyda , Lucenet Joanna 
Published: May 2024

AbstractIntroductionEmotion regulation (ER) develops during adolescence and contributes to psychosocial adjustment. Individual differences in the development of ER strategies may be related to cognitive processes responsible for managing goal‐directed behaviors, namely executive functions (EFs). This study examined (1) examined how difficulties in specific EFs (i.e., inhibition, flexibility and working memory) predict the use of ER strategies (i.e., reappraisal, distraction, expressive suppression, rumination, support‐seeking) in an emotion‐specific approach and (2) investigated these links across three different age groups (corresponding to early, middle and late adolescence), considering the nonlinear evolution of the relationships between EF and ER strategies during adolescence.MethodsThe sample was composed of 1076 adolescents aged from 12 to 19 years old who completed questionnaires on EF difficulties (i.e., inhibition, flexibility, and working memory) and ER strategies (i.e., distraction, reappraisal, expressive suppression, social support‐seeking, and rumination).ResultsResults showed various complex relationships between EFs and ER. Flexibility issues were related to rumination at all ages, while inhibition and flexibility difficulties were negatively linked to reappraisal in mid‐ to late adolescence. Many relationships were emotion‐ and age‐dependent.ConclusionsThese findings support the link between cognitive and emotional regulatory processes. Its complex evolution during adolescence opens a new avenue for future research.
Prediction of Pediatric Pharmacokinetics for CYP3A4 Metabolized Drugs: Comparison of the Performance of Two Hepatic Ontogeny Within a Physiologically Based Pharmacokinetic Model
Authors: Codaccioni Marc , Southall Rosalind L. , Dinh Jean , Johnson Trevor N. 
Published: May 2024

AbstractThe rapid growth in the use of pediatric physiologically based pharmacokinetic (PBPK) models, particularly for regulatory applications, has focused emphasis on model verification and ensuring system parameters are robust, including how these change with age. Uncertainty remains regarding the ontogeny of some enzymes and transporters, in this study 2 published ontogeny profiles for hepatic CYP3A4 were compared. Clinical pharmacokinetic data on 4 intravenously administered CYP3A4 substrates (alfentanil, fentanyl, midazolam, and sildenafil) used across the pediatric age range was collected from the literature. The PBPK models were verified in the adult population and then used to compare the Salem and a modified Upreti ontogeny profiles for CYP3A4 in terms of parent drug clearance and area under the curve from birth onward. Overall, the modified Upreti ontogeny profile resulted in 15 out of 17 age‐related predictions within 2‐fold and 12 out of 17 predictions within 1.5‐fold ranges of observed values, for the Salem ontogeny these values were 12 out of 17 and 8 out of 17, respectively. The Upreti ontogeny profile performed better than Salem, average fold error and absolute average fold error were 1.14 and 1.35 compared to 1.56 and 1.90, respectively.Identifying the optimal CYP3A4 ontogeny is important for regulatory use of PBPK especially given the number of drugs cleared by this enzyme. This study broadens the evidence from previous studies that Upreti is more favorable than Salem, but further work is needed especially in the neonatal and early infant age range.
Experiences of oral pre‐exposure prophylaxis use among heterosexual men accessing sexual and reproductive health services in South Africa: a qualitative study
Authors: Cholo Fatima Abegail , Dada Siphokazi , Martin Catherine Elizabeth , Mullick Saiqa 
Published: May 2024

AbstractIntroductionSouth African men face a substantial burden of HIV and are less likely to test for HIV and initiate antiretroviral therapy if tested positive and more likely to die from AIDS‐related causes than women. In addition to condoms and circumcision, guidelines provide for the use of daily oral pre‐exposure prophylaxis (PrEP) as an HIV prevention intervention for any men who recognize their need and request PrEP. However, heterosexual men have not been a focus of PrEP programmes, and since its introduction, there is limited literature on PrEP use among men in South Africa. This study explores the experiences, motivators and barriers to oral PrEP use among heterosexual men accessing primary healthcare services in South Africa.MethodsThis study forms part of a mixed‐methods implementation science study aimed at generating evidence for oral PrEP introduction and conducted in primary healthcare clinics in South Africa since 2018. Men aged ≥15 years who initiated oral PrEP and enrolled in a parent cohort study were purposefully invited to participate in an in‐depth interview (IDI). Between March 2020 and May 2022, 30 men participated in IDIs exploring their motivators for PrEP use, and experiences with accessing health services. Interviews were audio recorded, transcribed and analysed thematically.ResultsThe final analysis included 28 heterosexual men (18–56 years old). Motivations to initiate PrEP included fear of acquiring HIV, self‐perceived vulnerability to HIV and mistrust in relationships; health systems factors which motivated PrEP use included the influence of healthcare providers, educational materials and mobile services. Perceived reduction in HIV vulnerability and changing proximity to partners were reasons for PrEP discontinuation. Side effects, daily‐pill burden and stigma were noted as challenges to PrEP use. Health system barriers to PrEP use included limited PrEP availability, school and work demands, and inconsistent mobile clinic schedules.ConclusionsOur study reports on the experiences of heterosexual men accessing oral PrEP in real‐world settings and contributes to the limited literature among this population. We highlight multiple levels which could be strengthened to improve men's PrEP use, including individual support, education among partners and communities, and addressing health system barriers to access.