bluuebunny/crossref_metadata_2025_split huggingface dataset:
Trauma nursing competency in the emergency department: a concept analysis
Authors: Baik Dain , Yi Nayeon , Han Ol , Kim Yeongeun 
Published: June 2024

ObjectivesDespite numerous published concept analyses of nursing competency, the specific understanding of trauma nursing competency in emergency departments remains limited, with no clear definition. This study aimed to clarify the definitions and attributes of trauma nursing competencies in emergency departments.DesignWalker and Avant’s method was used to clarify the concept of trauma nursing competency in emergency departments.Data sourcesPubMed, EMBASE, CINAHL and RISS were searched from inception to 23 April 2023.Eligibility criteriaRelevant studies that included combinations of the terms ‘nurse’, ‘nursing’, ‘emergency’, ‘trauma’, ‘competency’, ‘capability’ and ‘skill’ were selected. We restricted the literature search to English and Korean full-text publications, with no limit on the publication period; grey literature was excluded.Data extraction and synthesisThis study uses defining attributes, antecedents and consequences extracted through data analysis. To aid comprehension of the model, related and contrary cases of the concept were created, and empirical referents were defined.ResultsAfter excluding duplicates, irrelevant studies, incomplete texts and articles unrelated to the context and study population, 15 of the initial 927 studies were included. Five additional studies were added after a manual search of the references. The final concept analysis therefore included 20 studies. The attributes of trauma nursing competency for emergency nurses included ‘rapid initial assessments considering injury mechanisms’, ‘priority determinations based on degrees of urgency and severity’, ‘clinical knowledge of trauma nursing’, ‘skills of trauma nursing’, ‘interprofessional teamwork’ and ‘emotional care’.ConclusionsThe concept analysis revealed that it is possible to promote the enhancement and development of trauma nursing competency in emergency departments across various contexts, such as clinical practice, education, research and organisational settings. This could ultimately improve trauma nursing quality and treatment outcomes.
Relationship between perceived organisational support, self-efficacy, proactive personality and career self-management among nurses: a moderated mediation analysis
Authors: Ni Yunxia , LI Linjuan , Bao Yun , You Guiying , Li Jiping 
Published: June 2024

ObjectivesCareer self-management is believed to be a critical behaviour in the new career era. However, the underlying mechanisms that stimulate nurses’ career self-management are unclear. The aim of this study was to examine the mediating effect of self-efficacy and the moderating effect of proactive personality on the relationship between perceived organisational support and career self-management among nurses.DesignThis was a cross-sectional survey.Setting and participantsA total of 1866 nurses from 15 hospitals across 15 cities in China were recruited for this study.Primary and secondary outcome measuresThe Perceived Organizational Support Scale, General Self-efficacy Scale, Proactive Personality Scale and Individual Career Management Questionnaire were used. Data were analysed using moderated mediation regressions with Hayes’ PROCESS macro in SPSS version 26.0.ResultsGeneral self-efficacy mediated the relationship between perceived organisational support and career self-management. Proactive personality moderated the direct (B=0.043, p<0.001, 95% CI 0.026 to 0.060) and indirect relationship (B=0.098, p<0.001, 95% CI 0.074 to 0.123) between perceived organisational support and career self-management. Further, the positive effects of perceived organisational support on general self-efficacy and career self-management were stronger for nurses with a high level of proactive personality. The model explained 47.2% of the variance incareer self-management.ConclusionThe findings highlight the crucial benefits of self-efficacy and important conditional effects of perceived organisational support on nurses’ career self-management.
Do coronary stent policies affect the cost-effectiveness of percutaneous coronary intervention among patients with acute coronary syndrome in Shanghai? A retrospective cohort study based on real-world and propensity score-matched data
Authors: Lu Dongzhe , Shao Zhenyi , Wang Yue , Xue Di 
Published: June 2024

ObjectivesThis study aimed to assess whether the national centralised volume-based procurement policy and the Shanghai government’s supportive measures (coronary stent policies) implemented in Shanghai, China, on 20 January 2021 affected the cost-effectiveness of percutaneous coronary intervention (PCI) in patients with acute coronary syndrome (ACS) in the year after surgery.DesignA retrospective cohort study based on real-world data and propensity score (PS)-matched data was conducted to compare the cost-effectiveness of PCI before and after policy implementation.Patients and settingPatients with ACS who had undergone first-time PCI over 1 year previously in hospitals in Shanghai and were discharged between 1 March 2019 and 30 April 2022 were included in the study.Outcome measuresIn the present study, cost was defined as total direct medical expenses, and effectiveness was defined as the prevention of major adverse cardiac events (MACEs). Incremental cost-effectiveness ratios (ICERs) were used to measure the cost-effectiveness of PCI in patients with ACS 1 year after surgery.ResultsThe study included 31 760 patients. According to real-world and PS-matched data, the implementation of coronary stent policies in Shanghai reduced the total medical cost of patients with ACS 1 year after PCI by 24.39% (p<0.0001) and 22.26% (p<0.0001), respectively. The ICERs were ¥−1131.72 and ¥−842.00 thousand per MACE avoided, respectively. The ICERs were robust to parameter uncertainty, and there was a substantial chance for policy implementation to improve the cost-effectiveness of PCI among patients with ACS in the short term.ConclusionsThe implementation of coronary stent policies has improved the cost-effectiveness of PCI for patients with ACS in the short term. The long-term impact of coronary stent policies on the cost-effectiveness of PCI in patients with ACS or other coronary heart diseases should be assessed in the future.
Central nervous system tumours and occupational ionising radiation exposure: a nested case–control study among the ORICAMs cohort of healthcare workers in France
Authors: Lopes Julie , Baudin Clémence , Rousseau Frédéric , Roy Hervé , Lestaevel Philippe , Caër-Lorho Sylvaine , Bensefa-Colas Lynda , Leuraud Klervi , Bernier Marie-Odile 
Published: June 2024

ObjectiveThis study aimed at investigating the relationship between occupational exposure to external ionising radiation and central nervous system (CNS) tumours mortality in healthcare workers working in France.Design and settingThe Occupational Radiation-Induced Cancer in Medical staff (ORICAMs) nested case–control study was conducted based on the dosimetric records of the national register of occupational dosimetry (Système d’information de la surveillance de l’exposition aux rayonnements ionisants).Participants and methods33 CNS tumour deaths occurred between 2002 and 2012 among the ORICAMs cohort composed of 164 015 healthcare workers. Each case was matched to five controls alive at the time of the corresponding case’s death, based on sex, year of birth, date of enrolment in the cohort and duration of follow-up. All participants were badge monitored for external radiation exposure, expressed in Hp(10). Conditional logistic regression was used to analyse the dose–response relationship between radiation dose and CNS mortality.ResultsCases were exposed to a mean cumulative career radiation dose of 5.8±13.7 (max: 54.3) millisievert (mSv) compared with 4.1±15.2 (142.2) mSv for controls. No statistically significant association was found between CNS tumour mortality and cumulative whole-body career dose (OR=1.00, 95% CI 0.98 to 1.03), duration of exposure (OR=1.03; 95% CI 0.95 to 1.12) or age at first exposure (OR=0.98; 95% CI 0.91 to 1.06).ConclusionWe found no evidence of an association between external radiation exposure and CNS tumour risk in healthcare workers. Limitations of the study include low statistical power and short duration of follow-up.
Mapping the evidence on integrated service delivery for non-communicable and infectious disease comorbidity in sub-Saharan Africa: protocol for a scoping review
Authors: Ibro Shemsedin Amme , Kasim Ahmed Zeynudin , Seid Sheka Shemsi , Abdusemed Kedir Abdella , Senbiro Ismael Ahmed , Waga Sultan Suleman , Abamecha Fira , Azalework Henok Gulilat , Soboka Matiwos , Gebresilassie Addisalem , Tesfaye Selam , Abafogi Abdulhakim Abamecha , Merga Hailu , Husen Abdusemed , Beyene Desalew Tilahun 
Published: June 2024

IntroductionThe concurrent occurrence of infectious diseases (IDs) and non-communicable diseases (NCDs) presents complex healthcare challenges in sub-Saharan Africa (SSA), where healthcare systems often grapple with limited resources. While an integrated care approach has been advocated to address these complex challenges, there is a recognised gap in comprehensive evidence regarding the various models of integrated care, their components and the feasibility of their implementation. This scoping review aims to bridge this gap by examining the breadth and nature of evidence on integrated care models for NCDs and IDs within SSA, thereby updating the current evidence base in the domain.Methods and analysisBased on the Joanna Briggs Institute (JBI) framework for scoping reviews, this study will include peer-reviewed and grey literature reporting on integrated care models for NCD-ID comorbidities in SSA. A comprehensive search of published sources in electronic databases (PubMed, Scopus, Embase, the Cochrane Library, Health System Evidence and Research4Life) and grey literature (Google Scholar, EBSCO Open Dissertations and relevant organisational websites) will be conducted to identify sources of information reported in English from 2018 onwards. The review will consider sources of evidence reporting on integrated care model for NCDs such as diabetes; chronic cardiovascular, respiratory and kidney diseases; cancers; epilepsy; and mental illness, and comorbid IDs such as HIV, tuberculosis and malaria. All sources of evidence will be considered irrespective of the study designs or methods used. The review will exclude sources that solely focus on the differentiated or patient-centred care delivery approach, and that focus on other conditions, populations or settings. The reviewers will independently screen the sources for eligibility and extract data using a JBI-adapted data tool on the Parsifal review platform. Data will be analysed using descriptive and thematic analyses and results will be presented in tables, figures, diagrams and a narrative summary.Ethics and disseminationEthical approval is not required for this review as it will synthesise published data and does not involve human participants. The final report will be submitted for publication in a peer-reviewed journal. The findings will be used to inform future research.Study registrationOSF:https://doi.org/10.17605/OSF.IO/KFVEY.
A complete set of 4-point amplitudes in the constructive Standard Model
Authors: Christensen Neil 
Published: June 2024

AbstractWe present a complete set of 4-point amplitudes in the constructive Standard Model at tree level. Any 4-point amplitude can be obtained from the results presented here by a suitable choice of masses, a permutation of the particles (by crossing symmetry), and a reversal of the momenta of the outgoing particles. We have validated all of these amplitudes by comparing with Feynman diagrams for a variety of masses, scattering energy and angles, and helicities of the photons and gluons, when they are in the initial states. The standard constructive techniques work for these amplitudes without the need for any contact terms and indeed, contact terms are not allowed. Only three 4-point vertices are used (allowed), involving the Higgs boson and the W and Z bosons. When external photons or gluons are present, the amplitude simplifies to a single spinor-product structure, present in the numerator. In a few cases, however, the propagator structure is more complex, with different terms depending on the charge or color structure. In the case of internal photons or gluons, we find that the massless limit of a massive photon or gluon diagram gives the correct result in all cases. We have additionally found that using the x factor directly gives the correct result in all cases and agrees with the massless limit calculation.
Efficient Static Vulnerability Analysis for JavaScript with Multiversion Dependency Graphs
Authors: Ferreira Mafalda , Monteiro Miguel , Brito Tiago , Coimbra Miguel E. , Santos Nuno , Jia Limin , Santos José Fragoso 
Published: June 2024

While static analysis tools that rely on Code Property Graphs (CPGs) to detect security vulnerabilities have proven effective, deciding how much information to include in the graphs remains a challenge. Including less information can lead to a more scalable analysis but at the cost of reduced effectiveness in identifying vulnerability patterns, potentially resulting in classification errors. Conversely, more information in the graph allows for a more effective analysis but may affect scalability. For example, scalability issues have been recently highlighted in ODGen, the state-of-the-art CPG-based tool for detecting Node.js vulnerabilities.
This paper examines a new point in the design space of CPGs for JavaScript vulnerability detection. We introduce the Multiversion Dependency Graph (MDG), a novel graph-based data structure that captures the state evolution of objects and their properties during program execution. Compared to the graphs used by ODGen, MDGs are significantly simpler without losing key information needed for vulnerability detection. We implemented Graph.js, a new MDG-based static vulnerability scanner specialized in analyzing npm packages and detecting taint-style and prototype pollution vulnerabilities. Our evaluation shows that Graph.js outperforms ODGen by significantly reducing both the false negatives and the analysis time. Additionally, we have identified 49 previously undiscovered vulnerabilities in npm packages.
2-Mercaptoethanesulfonic Acid as an Effective Free-Radical Scavenger in Perfluorosulfonic Acid Membrane-Based Polymer Electrolyte Membrane Fuel Cells
Authors: Barik Bapun , Singh Bhupendra , Namgung Yeon , Islam Md Shoriful , Han Mi-Kyung , Park Jun-Young , Song Sun-Ju 
Published: June 2024

Ceria nanoparticle-based free-radical scavengers for the mitigation of oxidative damage in perfluorosulfonic acid (PFSA)-based polymer electrolyte membrane fuel cells (PEMFCs) suffer from the drawbacks of lowered protonic conductivity and leaching in the acidic environment of a PEMFC. As an alternative to ceria, here we demonstrate that oxidative damage can be mitigated by functionalization of Nafion with 2-Mercaptoethanesulfonic acid (MESA) in different (0.1–1.0 wt%) ratio. The spectroscopic investigation indicated successful functionalization of MESA over the Nafion chain and resulting Nafion-MESA composite membranes displayed improved hydration and swelling behavior, and thermal and mechanical properties. At ≤60 °C (95% relative humidity), the protonic conductivity of composite membranes was higher than/equivalent to that of pristine Nafion membrane; however, at ≥70 °C it was ∼6%–8% lower. At 80 °C, conductivity of Nafion-MESA-0.1 wt%, Nafion-MESA-0.25 wt%, pristine Nafion, and state-of-the-art Nafion-CeO2−1wt% membranes were 1.72 × 10−1, 1.67 × 10−1, 1.8 × 10−1, and 1.6 × 10−1 S∙cm−1, respectively. The fluoride emission rate value for the same membranes were 0.30, 0.17, 1.39, and 0.27 mg∙g−1, respectively, thus indicating that Nafion-MESA membranes can substitute the ceria-based membranes as a chemically stable membrane electrolyte in PEMFCs.
Obesity Induces Temporally Regulated Alterations in the Extracellular Matrix That Drive Breast Tumor Invasion and Metastasis
Authors: Conner Sydney J. , Borges Hannah B. , Guarin Justinne R. , Gerton Thomas J. , Yui Anna , Salhany Kenneth J. , Mensah Diamond N. , Hamilton Grace A. , Le Giang H. , Lew Katherine C. , Zhang Crystal , Oudin Madeleine J. 
Published: June 2024

AbstractObesity is associated with increased incidence and metastasis of triple-negative breast cancer, an aggressive breast cancer subtype. The extracellular matrix (ECM) is a major component of the tumor microenvironment that drives metastasis. To characterize the temporal effects of age and high-fat diet (HFD)–driven weight gain on the ECM, we injected allograft tumor cells at 4-week intervals into mammary fat pads of mice fed a control or HFD, assessing tumor growth and metastasis and evaluating the ECM composition of the mammary fat pads, lungs, and livers. Tumor growth was increased in obese mice after 12 weeks on HFD. Liver metastasis increased in obese mice only at 4 weeks, and elevated body weight correlated with increased metastasis to the lungs but not the liver. Whole decellularized ECM coupled with proteomics indicated that early stages of obesity were sufficient to induce changes in the ECM composition. Obesity led to an increased abundance of the proinvasive ECM proteins collagen IV and collagen VI in the mammary glands and enhanced the invasive capacity of cancer cells. Cells of stromal vascular fraction and adipose stem and progenitor cells were primarily responsible for secreting collagen IV and collagen VI, not adipocytes. Longer exposure to HFD increased the invasive potential of ECM isolated from the lungs and liver, with significant changes in ECM composition found in the liver with short-term HFD exposure. Together, these data suggest that changes in the breast, lungs, and liver ECM underlie some of the effects of obesity on triple-negative breast cancer incidence and metastasis.Significance: Organ-specific extracellular matrix changes in the primary tumor and metastatic microenvironment are mechanisms by which obesity contributes to breast cancer progression.
Chronic Health Conditions, Disability, and Physical and Cognitive Limitations among LGBTQ+ Cancer Survivors
Authors: Waters Austin R. , Jin Mu , Jones Shaun R. , Datta Geetanjali D. , Butler Eboneé N. , Kent Erin E. , Nichols Hazel B. , Tan Kelly 
Published: June 2024

Abstract

Background:
Cancer survivors are at high risk for chronic health conditions and physical and cognitive limitations. However, few studies have explored these outcomes among Lesbian, Gay, Bisexual, Transgender, Queer, Plus (LGBTQ+) survivors.

Methods:
We used pooled, weighted Behavioral Risk Factor Surveillance System data from 23 states that completed two specific modules at least once from 2020 to 2022. We calculated age-adjusted prevalence for heart disease, asthma, chronic obstructive pulmonary disease, depressive disorders, myocardial infarction, kidney disease, stroke, diabetes, hearing disability, vision disability, cognitive limitations, and difficulty walking, dressing, and running errands in LGBTQ+, lesbian, gay, or bisexual, transgender or gender nonconforming (TGNC), and non-LGBTQ+ cancer survivors. Four multivariable logistic regression models controlling for different factors were run for each outcome.

Results:
Of 40,990 cancer survivors, 1,715 were LGBTQ+. LGBTQ+ survivors had significantly higher age-adjusted prevalence of all outcomes. The prevalence of all outcomes was the highest among TGNC survivors, except for depressive disorders and cognitive limitations. LGBTQ+ survivors had higher odds of reporting asthma [adjusted OR (aOR): 1.5; 95% confidence interval (CI), 1.2–1.9], depressive disorders (aOR: 1.9; 95% CI, 1.6–2.4), kidney disease (aOR: 1.5; 95% CI, 1.1–2.1), stroke (aOR: 1.7; 95% CI, 1.3–2.3), diabetes (aOR: 1.3; 95% CI, 1.0–1.6), vision disability (aOR: 1.6; 95% CI, 1.2–2.2), cognitive limitations (aOR: 2.3; 95% CI, 1.8–2.9), difficulty walking (aOR: 1.7; 95% CI, 1.3–2.0), dressing (aOR: 2.0; 95% CI, 1.5–2.7), and running errands (aOR: 1.6; 95% CI, 1.3–2.1). In TGNC models, TGNC cancer survivors had increased odds of most outcomes in comparison to cisgender survivors.

Conclusions:
LGBTQ+ cancer survivors have an elevated burden of all chronic health conditions, disabilities, and limitations assessed. TGNC cancer survivors experience even higher burden of the same outcomes.

Impact:
Findings highlight substantial disparities regarding the health of LGBTQ+ cancer survivors.
See related In the Spotlight, p. 1395
Use of Nonsteroidal Anti-Inflammatory Drugs and Pancreatic Cancer Risk in the Women’s Health Initiative
Authors: Brasky Theodore M. , Jager Leah R. , Newton Alison M. , Li Xilin , Loomans-Kropp Holli A. , Hays John L. , Margolis Karen L. , Luo Juhua 
Published: June 2024

Abstract

Background:
Pancreatic cancer is among the most fatal human cancers and the fourth leading cause of cancer death in the United States. Evidence suggests that chronic inflammation may play a role in pancreatic carcinogenesis and its inhibition through nonsteroidal anti-inflammatory drugs (NSAID) may reduce pancreatic cancer incidence.

Methods:
We examined associations of total and individual NSAIDs with pancreatic cancer risk among postmenopausal women participating in the Women’s Health Initiative observational study and clinical trial cohorts. Among 117,452 women, aged 55 to 79 years, 727 incident pancreatic cancer cases were reported over 18 years of follow-up. Cox regression was used to estimate hazard ratio (HR) and 95% confidence interval (CI) for associations between NSAIDs and pancreatic cancer risk.

Results:
Relative to non-use, consistent use of any NSAID was inversely associated with pancreatic cancer risk (HR 0.71, 95% CI, 0.59–0.87), primarily driven by strong associations for aspirin use (HR 0.67, 95% CI, 0.52–0.86). Use of total or individual non-aspirin NSAIDs was not associated with pancreatic cancer. Upon stratified analysis, we observed stronger associations for NSAIDs among participants with prevalent diabetes (HR 0.28, 95% CI, 0.10–0.75) relative to those without (HR 0.75, 95% CI, 0.61–0.92; P-interaction = 0.03).

Conclusions:
Additional large prospective studies with careful measurement of NSAID type, dose, and frequency are needed to further investigate the possibility of added benefit among individuals diagnosed with diabetes.

Impact:
This study adds to existing evidence from prospective studies and clinical trials suggesting that use of aspirin may provide moderate benefit for pancreatic cancer prevention.