bluuebunny/crossref_metadata_2025_split huggingface dataset:
The rise of the distributed workforce: strategic HR’s role in optimising hybrid and remote models
Authors: Tenakwah Emmanuel Senior , Otchere-Ankrah Benjamin 
Published: June 2024

Purpose
The purpose of this paper is to explore the critical role of strategic HR in helping organisations optimise hybrid and remote work to seise the opportunities of the distributed workforce that has evolved in response to the COVID-19 pandemic.

Design/methodology/approach
This paper combines industry figures, academic studies and emerging HR best practices to illustrate integrated strategies for how strategic HR can develop with the distributed workforce.

Findings
Organisations that implement holistically integrated HR strategies for the distributed workforce are best suited to attract, engage and retain talent, no matter where employees are located. Strategic HR helps organisations succeed in areas such as facilitating virtual collaboration, designing successful workplace experiences, expanding their talent markets and developing new leadership skills and values for geographically dispersed teams.

Originality/value
This paper provides a novel approach to the concept of work and the role of strategic HR in the redesign of it. This paper introduces novel concepts and actionable theory for reaching the change to these newly disparate models that will affect the design of the workplace for years to come.
A serial mediation model for investigating the intention to use algorithmic trading platforms among retail investors in India
Authors: Bunkar Bhumika , Ramaiah Kasilingam 
Published: June 2024

Purpose
In developing nations, the utility and intention to use algorithmic trading (AT) platforms and financial services are predominantly reliant on investors’ technological knowledge. This study aims to investigate the effect of investor awareness of AT (AAT), trust in AT (TAT), and acceptance of innovativeness (AOI) on intention to use the AT (IUAT) platforms among Indian investors.

Design/methodology/approach
The authors used a structured questionnaire with a five-point Likert scale to collect the data from 392 Indian retail investors through a purposeful sampling approach. And, the authors carried out structural equation modeling to analyze the serial mediation among the latent (independent) and observed (dependent) variables.

Findings
The findings suggest that investor awareness exerts a statistically significant and positive effect on the IUAT platforms. Additionally, TAT platforms and innovation acceptance, independently as well as mediator, significantly influences the usage decision of AT platforms among Indian investors.

Research limitations/implications
The findings on determinants of AT platform usage can guide investment regulators to promote technological awareness, build trust, and provide a safe algorithmic trading environment for retail investors in India. The suggestions may take the edge off a few behavioural impediments among the investors w.r.t. AT platform usage.

Originality/value
Off the back of extensive literary exploration our field research is among the first that probes an intellectual discourse and documents the empirical evidence on linkages between investor AAT, TAT, AOI and the IUAT platforms in the Indian stock market.
Extraperitoneal sigmoidopexy versus sigmoidectomy for sigmoid volvulus: A prospective comparative study
Authors: Ibrahim Mostafa , Raafat Mohamad 
Published: June 2024

AbstractAimExtraperitoneal sigmoidopexy is a simple, safe and effective non‐resective procedure with minimal morbidity and mortality rates.Patients and MethodsThis prospective comparative study involved 105 patients with uncomplicated sigmoid volvulus at Asyut University Hospitals, Egypt, from June 2021 to January 2023. The study population was divided into two groups: Group A, which underwent extraperitoneal sigmoidopexy, and Group B, which was treated with sigmoidectomy and primary anastomosis.ResultsThe study included 105 cases. A total of 56 (53.4%) patients underwent extraperitoneal sigmoidopexy (Group A) and 49 (46.6%) patients underwent sigmoidectomy (Group B). The mean age was 61.33 (standard deviation [SD] 1.65) for Group A and 67.9 (SD 1.69) for Group B (P = .36). The mean operative time (minutes) was 62.25 (SD 1.38) for Group A and 87.60 (SD 2.38) for Group B (P < .0001). The mean hospital stay (days) was 6.25 (SD 0.29) for Group A and 9.04 (SD 0.34) for Group B (P < .0001). There was a significant difference in overall morbidity and recurrence rate, while no significant difference was observed in intensive care unit admission, additional surgery and mortality between the two groups.ConclusionExtraperitoneal sigmoidopexy emerges as a simple, safe and effective treatment option for non‐complicated sigmoid volvulus. Despite a higher recurrence rate, it demonstrates lower morbidity and mortality compared with sigmoidectomy.
The role of the plant microbiome for forestry, agriculture and urban greenspace in times of environmental change
Authors: Brüssow Felix , Bruessow Friederike , Brüssow Harald 
Published: June 2024

AbstractThis Lilliput article provides a literature overview on ecological effects of the plant microbiome with a focus on practical application in forestry, agriculture and urban greenspace under the spectre of climate change. After an overview of the mostly bacterial microbiome of the model plant Arabidopsis thaliana, worldwide data from forests reveal ecological differentiation with respect to major guilds of predominantly fungal plant root symbionts. The plant‐microbiome association forms a new holobiont, an integrated unit for ecological adaptation and evolutionary selection. Researchers explored the impact of the microbiome on the capacity of plants to adapt to changing climate conditions. They investigated the impact of the microbiome in reforestation programs, after wildfire, drought, salination and pollution events in forestry, grasslands and agriculture. With increasing temperatures plant populations migrate to higher latitudes and higher altitudes. Ecological studies compared the dispersal capacity of plant seeds with that of soil microbes and the response of soil and root microbes to experimental heating of soils. These studies described a succession of microbiome associations and the kinetics of a release of stored soil carbon into the atmosphere enhancing global warming. Scientists explored the impact of synthetic microbial communities (SynComs) on rice productivity or tea quality; of whole soil addition in grassland restoration; or single fungal inoculation in maize fields. Meta‐analyses of fungal inoculation showed overall a positive effect, but also a wide variation in effect sizes. Climate change will be particularly prominent in urban areas (“urban heat islands”) where more than half of the world population is living. Urban landscape architecture will thus have an important impact on human health and studies started to explore the contribution of the microbiome from urban greenspace to ecosystem services.
Non‐transgenic guinea pig strains exhibit divergent age‐related changes in hippocampal mitochondrial respiration
Authors: Walsh Maureen A. , Latham Amanda S. , Zhang Qian , Jacobs Robert A. , Musci Robert V. , LaRocca Thomas J. , Moreno Julie A. , Santangelo Kelly S. , Hamilton Karyn L. 
Published: June 2024

AbstractAimAlzheimer’s disease (AD) is the most common form of dementia. However, while 150+ animal models of AD exist, drug translation from preclinical models to humans for treatment usually fails. One factor contributing to low translation is likely the absence of neurodegenerative models that also encompass the multi‐morbidities of human aging. We previously demonstrated that, in comparison to the PigmEnTed (PET) guinea pig strain which models “typical” brain aging, the Hartley strain develops hallmarks of AD like aging humans. Hartleys also exhibit age‐related impairments in cartilage and skeletal muscle. Impaired mitochondrial respiration is one driver of both cellular aging and AD. In humans with cognitive decline, diminished skeletal muscle and brain respiratory control occurs in parallel. We previously reported age‐related declines in skeletal muscle mitochondrial respiration in Hartleys. It is unknown if there is concomitant mitochondrial dysfunction in the brain.MethodsTherefore, we assessed hippocampal mitochondrial respiration in 5‐ and 12‐month Hartley and PET guinea pigs using high‐resolution respirometry.ResultsAt 12 months, PETs had higher complex I supported mitochondrial respiration paralleling their increase in body mass compared to 5 months PETs. Hartleys were also heavier at 12 months compared to 5 months but did not have higher complex I respiration. Compared to 5 months Hartleys, 12 months Hartleys had lower complex I mitochondrial efficiency and compensatory increases in mitochondrial proteins collectively suggesting mitochondrial dysfunction with age.ConclusionsTherefore, Hartleys might be a relevant model to test promising therapies targeting mitochondria to slow brain aging and AD progression.
Treatment of inflammatory bowel disease with steroid‐sparing medications is age‐dependent – Results from a Danish nationwide cohort study, 2000–2018
Authors: Nordestgaard Rie Louise Møller , Wewer Mads Damsgaard , Malham Mikkel , Wewer Vibeke , Boysen Trine , Burisch Johan 
Published: June 2024

SummaryBackgroundPaediatric‐onset and elderly‐onset inflammatory bowel disease (IBD) present unique treatment challenges.AimsWe investigated treatment patterns following a first and second course of systemic steroids in paediatric‐ and elderly‐onset IBD and compared them to adult‐onset IBD.MethodsAll patients diagnosed with Crohn's disease (CD) or ulcerative colitis (UC) between 2000 and 2018 were identified through the Danish healthcare registries. Patients were divided into groups based on their age at diagnosis. Kaplan–Meier plots were prepared for medications and surgeries after diagnosis and after the first and second courses of systemic steroids. Hazard ratios (HR) and 95% confidence intervals (CI) were calculated using multivariate Cox regression analysis for steroid‐sparing medications.Results1851 CD (13%) and 1687 (6%) UC patients were paediatric‐onset, while 2952 (20%) CD and 5812 (23%) UC patients were elderly‐onset. Paediatric‐onset more frequently received immunomodulators [CD: HR: 1.64, CI: 1.52–1.77, UC: HR: 2.29, CI: 2.02–2.61] and biologics [CD: HR: 1.43, CI: 1.25–1.65, UC: HR: 1.27, CI: 0.99–1.64], while elderly‐onset less frequently received immunomodulators [CD: HR: 0.39, CI: 0.35–0.44, UC: HR: 0.58, CI: 0.50–0.67] and biologics [CD: HR: 0.19, CI: 0.14–0.25, UC: HR: 0.36, CI: 0.27–0.48] compared to adult‐onset age groups. After two courses of systemic steroids, elderly‐onset still received less steroid‐sparing medications. High frailty was associated with lower usage of medications for elderly‐onset.ConclusionThere are significant differences in the use of steroid‐sparing medication between age of onset, even after two courses with systemic steroids. High frailty could account for some of these differences in elderly‐onset IBD.
The resilience of parents of children with intellectual disabilities: An effort from self‐regulation and career burnout
Authors: Cheng Sanyin , Xuxu Li , Deng Meng 
Published: June 2024

AbstractBackgroundResearchers have made great efforts to help parents of children with intellectual disabilities overcome the stress and burden. Learning to be resilient is one effective strategy.AimThis study explores resilience among parents of children with intellectual disabilities and how career burnout and self‐regulation relate to parents' resilience in mainland China.MethodsThe Burnout Scale, the Self‐Regulation Scale and the Resilience Scale were administered to 324 parents of children with intellectual disabilities.ResultsResults showed that career burnout significantly negatively influenced resilience (β = −0.269, p = 0.000), while self‐regulation significantly positively influenced resilience (β = 0.754, p = 0.000). In addition, self‐regulation moderated the relationships between career burnout and resilience (β = 0.176, p = 0.003).ConclusionThe findings offer valuable insights for enhancing the resilience of parents of children with intellectual disabilities.
Re‐analysis of whole genome sequencing ends a diagnostic odyssey: Case report of an RNU4‐2 related neurodevelopmental disorder
Authors: Schot Rachel , Ferraro Federico , Geeven Geert , Diderich Karin E. M. , Barakat Tahsin Stefan 
Published: June 2024

AbstractDespite increasing knowledge of disease‐causing genes in human genetics, approximately half of the individuals affected by neurodevelopmental disorders remain genetically undiagnosed. Part of this missing heritability might be caused by genetic variants outside of protein‐coding genes, which are not routinely diagnostically investigated. A recent preprint identified de novo variants in the non‐coding spliceosomal snRNA gene RNU4‐2 as a cause of a frequent novel syndromic neurodevelopmental disorder. Here we mined 164 whole genome sequencing (WGS) trios from individuals with neurodevelopmental or multiple congenital anomaly disorders that received diagnostic genomic investigations at our clinic. We identify a recurrent de novo RNU4‐2 variant (NR_003137.2(RNU4‐2):n.64_65insT) in a 5‐year‐old girl with severe global developmental delay, hypotonia, microcephaly, and seizures that likely explains her phenotype, given that extensive previous genetic investigations failed to identify an alternative cause. We present detailed phenotyping of the individual obtained during a 5‐year follow‐up. This includes photographs showing recognizable facial features for this novel disorder, which might allow prioritizing other currently unexplained affected individuals sharing similar facial features for targeted investigations of RNU4‐2. This case illustrates the power of re‐analysis to solve previously unexplained cases even when a diagnostic genome remains negative.
Periodontal conditions of teeth adjacent to dental implants with or without peri‐implantitis after non‐surgical therapy in patients treated for periodontitis: A retrospective study
Authors: Sung Cheng‐En , Chung Kwok‐Hung , Lin Fu‐Gong , Huang Ren‐Yeong , Cheng Wan‐Chien , Chen Wei‐Liang 
Published: June 2024

AbstractObjectivesTo retrospectively assess the periodontal conditions of teeth adjacent to and contralateral to implants presenting with or without peri‐implantitis, following non‐surgical periodontal and peri‐implant mechanical therapy.Materials and MethodsOne hundred and one patients with existing dental implants and chronic periodontitis, who underwent non‐surgical periodontal and peri‐implant mechanical therapy, were included. The periodontal clinical probing depth (PPD), gingival recession (GR), and bleeding on probing (BOP) were recorded at six sites around the adjacent (Adj‐) teeth and the contralateral (CL‐) teeth relative to the implant. The potential factors influencing the periodontal conditions of 316 teeth were analyzed by multivariate linear regression models with generalized estimating equation methods and α = .05.ResultsThe PPD of Adj‐teeth was significantly different from that of CL‐teeth before and after non‐surgical therapy when the implant was diagnosed with peri‐implantitis (PI) (p < .05). The PPD of teeth was shown to be affected by neighboring implants diagnosed with peri‐implantitis (β = .825 mm, p < .001), teeth adjacent to implants (β = .245 mm, p = .004), a molar tooth type (β = .435 mm, p = .019), and non‐surgical therapy (β = −.522 mm, p < .001).ConclusionsRelatively compromised periodontal conditions at Adj‐teeth after non‐surgical PI therapy were detected. Therefore, clinicians should be aware that non‐surgical therapy may be less successful at teeth adjacent to implants with PI.
Quantifying social capital creation in post‐disaster recovery aid in Indonesia: methodological innovation by an AI‐based language model
Authors: Marutschke Daniel Moritz , Nurdin Muhammad Riza , Hirono Miwa 
Published: June 2024

AbstractSmooth interaction with a disaster‐affected community can create and strengthen its social capital, leading to greater effectiveness in the provision of successful post‐disaster recovery aid. To understand the relationship between the types of interaction, the strength of social capital generated, and the provision of successful post‐disaster recovery aid, intricate ethnographic qualitative research is required, but it is likely to remain illustrative because it is based, at least to some degree, on the researcher's intuition. This paper thus offers an innovative research method employing a quantitative artificial intelligence (AI)‐based language model, which allows researchers to re‐examine data, thereby validating the findings of the qualitative research, and to glean additional insights that might otherwise have been missed. This paper argues that well‐connected personnel and religiously‐based communal activities help to enhance social capital by bonding within a community and linking to outside agencies and that mixed methods, based on the AI‐based language model, effectively strengthen text‐based qualitative research.
‘Forgotten crises’ as forgotten sites of knowledge production for building lasting peace
Authors: Tanyag Maria 
Published: June 2024

Abstract‘Forgotten crises’ constitute a permanent background to any present and future global humanitarian and development efforts. They represent a significant impediment to promoting lasting peace given concurrent catastrophes exacerbated by climate change. Yet, they are routinely neglected and remain unresolved. Building on critical and feminist approaches, this paper theorises them as forgotten sites of local knowledge production. It asks: what is local knowledge of and from forgotten crises? How can it be recovered and resignified, and what lessons can such knowledge provide at the global level? Drawing on examples from the intersections of conflict, disasters, and pandemics in the Philippines, the paper makes a case for valuing local knowledge arising from forgotten crises because of its potential contribution to adapting global humanitarian and development systems to address crises on multiple fronts. Such epistemic margins are generative of vantage points that can present a fuller account of how different crises interact and how best to respond to them.
Long‐term efficacy of washed microbiota transplantation in overweight patients
Authors: Lin Dejiang , Hu Dongxia , Song Youlin , He Xingxiang , Wu Lei 
Published: June 2024

AbstractBackgroundFaecal microbiota transplantation holds promise in mitigating fat accumulation and improving obesity. This study aimed to evaluate the long‐term efficacy of washed microbiota transplantation (WMT) among overweight patients.MethodsThe clinical data pertaining to the treatment of patients with WMT were collected retrospectively. Compared alterations in body mass index (BMI), blood glucose, blood lipids and blood pressure prior to and following WMT treatment. Comprehensive efficacy evaluation and atherosclerosis cardiovascular disease (ASCVD) grading evaluation were carried out, with an analysis of gut microbiota composition before and after WMT.ResultsA total of 186 patients were included (80 overweight, 106 normal weight). WMT not only had the effect of improving overweight patients to the normal weight patients (p < .001), but also could significantly reduce BMI in the long term by restoring gut microbiota homeostasis (p < .001). In addition, the BMI improvement value of multi course was more significant than that of single course or double course. WMT had a significant ASCVD downgrade effect on the high‐risk and medium‐risk groups outside 1 year, while it did not increase the risk of upgrading ASCVD for low‐risk group.ConclusionsWMT could significantly reduce the BMI of overweight patients and still had an improvement effect in the long term.
Hypoperfusion intensity ratio correlates with collaterals and predicts outcome and infarct volume in acute ischemic stroke patients
Authors: Busto Giorgio , Morotti Andrea , Casetta Ilaria , Barra Angelo , Fiorenza Alessandro , Di Pasquale Francesca , Maccaglia Maria Giulia , Toffali Maddalena , Mancini Sara , Carlesi Edoardo , Palumbo Vanessa , Lombardo Ivano , Padovani Alessandro , Fainardi Enrico 
Published: June 2024

AbstractBackgroundHypoperfusion Intensity Ratio (HIR) is associated with collaterals and outcome in acute ischemic stroke (AIS). We investigated whether a combined assessment of HIR and collaterals could provide an added value.MethodsRetrospective single‐center study, including AIS patients with large vessel occlusion and endovascular treatment 0–24 h from onset. Predictors of FIV and outcome (90 days modified Rankin Scale 0–1) were investigated with linear and logistic regression respectively. Subjects were stratified in three groups: poor collaterals (grade 0–3) with poor HIR (≥.4), good collaterals (grade 4–5) with poor HIR/poor collaterals with good HIR (<.4) and good collaterals with good HIR.ResultsWe included 337 patients (median age 77, 53.1% males), of whom 100 (29.7%) had excellent outcome. One hundred and forty five patients with favourable collateral and HIR profiles had smaller infarct (median poor collaterals with poor HIR 41 mL, good collaterals with poor HIR/poor collaterals with good HIR 21 mL and good collaterals with good HIR 11 mL, p <.001) and higher rates of excellent outcome (poor collaterals with poor HIR 15.7%, good collaterals with poor HIR/poor collaterals with good HIR 26.2% and good collaterals with good HIR 39.3% p =.001). Logistic regression showed that patients with favourable collateral and HIR profiles had the highest odds of good outcome (OR: 3.83, 95% CI 1.62–9.08, p =.002).ConclusionCollaterals and HIR are independent predictors of final infarct lesion and outcome in stroke patients and their integration provides an added value. These findings might inform clinical practice and future trials.
Regulation of SETD2 maintains immune regulatory function in macrophages to suppress airway allergy
Authors: Zhang Lei , Wang Junyi , Liu Xiaoyu , Xiao Xiaojun , Liu Yu , Huang Qinmiao , Li Jing , Li Guoping , Yang Pingchang 
Published: June 2024

AbstractSET domain‐containing 2 (SETD2) is a histone methyltransferase. It regulates the activity of H3K36me3 to enhance gene transcription. Macrophages (Mϕs) are one of the cell types involved in immune response. The purpose of this study is to clarify the role of SETD2 in regulating the immune property of Mϕ. The Mφs were isolated from the bronchoalveolar lavage fluid (BALF) and analysed through flow cytometry and RNA sequencing. A mouse strain carrying Mφs deficient in SETD2 was used. A mouse model of airway allergy was established with the ovalbumin/alum protocol. Less expression of SETD2 was observed in airway Mϕs in patients with allergic asthma. SETD2 of M2 cells was associated with the asthmatic clinical response. Sensitization reduced the expression of SETD2 in mouse respiratory tract M2 cells, which is associated with the allergic reaction. Depletion of SETD2 in Mφs resulted in Th2 pattern inflammation in the lungs. SETD2 maintained the immune regulatory ability in airway M2 cells. SETD2 plays an important role in the maintenance of immune regulatory property of airway Mφs.