bluuebunny/crossref_metadata_2025_split huggingface dataset:
ChemInform Abstract: Enantioselective Alkynylbenzaldehyde Cyclizations Catalyzed by Chiral Gold(I) Acyclic Diaminocarbene Complexes Containing Weak Au—Arene Interactions.
Authors: Handa Sachin , Slaughter LeGrande M. 
Published: July 2012

AbstractA variety of alcohols is applied in the tandem addition/cycloisomerization process where a bulky substituent at the binaphthyl core of the catalyst is crucial.
ChemInform Abstract: Iodine(III)‐Mediated Cyclization of Unsaturated O‐Alkyl Hydroxamates: Silyl‐Assisted Access to α‐Vinyl and α‐(2‐Silylvinyl) Lactams.
Authors: Wardrop Duncan J. , Yermolina Maria V. , Bowen Edward G. 
Published: July 2012

AbstractA general route is developed to unsaturated O‐alkyl hydroxamate precursors which are subjected to a chemoselective oxidative cyclization process.
ChemInform Abstract: Complex‐Induced Proximity Effect in the Regioselective Lithiation of Pyridine Derivatives.
Authors: Dhau Jaspreet S. , Singh Amritpal , Kasetti Yoganjaneyulu , Bharatam P. V. 
Published: July 2012

AbstractMonolithiation—electrophilic substitution of BF3‐complexed methylpyridines (I) proceeds exclusively at position 6 of the pyridine ring, leaving the methyl groups unsubstituted.
ChemInform Abstract: Furanyl Cyclic Amines: A Diastereoselective Synthesis of 2,6‐syn‐Disubstituted Piperidines under Thermodynamic Control.
Authors: O'Brien Matthew , Leach Andrew , Armstrong Roly J. , Chong Keting , Sheridan Ross 
Published: July 2012

AbstractTreatment of furanyl substituted 1,5‐tosylamino alcohols with TosOH under thermodynamic control allows highly diastereoselective access to 2,6‐syn‐substituted piperidines.
ChemInform Abstract: NHC‐Catalyzed Diastereoselective Synthesis of Multifunctionalized Piperidines via Cascade Reaction of Enals with Azalactones.
Authors: Singh Atul K. , Chawla Ruchi , Rai Ankita , Yadav Lal Dhar S. 
Published: July 2012

AbstractNHC‐catalyzed azalactone (I) and (IV) ring opening—piperidine ring‐closing cascade with α,β‐unsaturated aldehydes (II) and (V) in an one‐pot procedure is reported.
ChemInform Abstract: Chemical Generation of o‐Quinone Monoimines for the Rapid Construction of 1,4‐Benzoxazine Derivatives.
Authors: Bodipati Naganjaneyulu , Peddinti Rama Krishna 
Published: July 2012

AbstractTreatment of electron‐poor α‐aminophenols with PhI(O‐Ac)2 results in formation of o‐quinone monoimines.
ChemInform Abstract: Palladium‐Catalyzed Intramolecular Annulation of 3‐[2‐(2‐Iodobenzylamino)aryl]‐N‐arylpropiolamides: Synthesis of 3‐[5H‐Dibenzo[b,e]azepin‐11(6H)‐ylidene]indolin‐2‐ones.
Authors: Zou Tao , Zhang Xing‐Guo , Li Jin‐Heng , Deng Chen‐Liang , Tang Ri‐Yuan 
Published: July 2012

AbstractBoth an oxindole and a dibenzoazepine moiety are formed in a single step through a sequential arylation of the alkyne with the aryl iodide moiety and the annulation with the N‐arylamide group.
ChemInform Abstract: Chemoselectivity of the 1,3‐Dipolar Cycloaddition of Some Diazoalkanes with 1,5‐Benzodiazepine Derivatives.
Authors: Nsira Asma , Karoui Ahlem , Gharbi Rafik , Msaddek Moncef 
Published: July 2012

AbstractThe different behavior of 1,5‐benzodiazepines (I) and (V) during reaction with 2‐diazopropane and diphenyldiazomethane, resp., is studied.
ChemInform Abstract: Copper‐Catalyzed Cross‐Coupling Interrupted by an Opportunistic Smiles Rearrangement: An Efficient Domino Approach to Dibenzoxazepinones.
Authors: Kitching Matthew O. , Hurst Timothy E. , Snieckus Victor 
Published: July 2012

AbstractThe reaction includes a formal C—N coupling of secondary benzamides assisted by an unexpected Smiles rearrangement.
ChemInform Abstract: Ultrasound‐Assisted Synthesis of Novel α‐Aminophosphonates and Their Biological Activity.
Authors: Rasheed Syed , Venkataramana Katla , Chandrasekhar Kuruva , Fareeda Gemmalamadugu , Raju Chamarthi Naga 
Published: July 2012

AbstractA two‐step one‐pot ultrasound‐assisted synthesis of title aminophosphonates is presented.
ChemInform Abstract: Synthesis of 1‐[(Triisopropylsilyl)ethynyl] ‐1λ3,2‐benziodoxol‐3(1H)‐one and Alkynylation of Indoles, Thiophenes, and Anilines.
Authors: Brand Jonathan P. , Waser Jerome 
Published: July 2012

AbstractAn improved synthesis of title compound (III) is developed which is employed to the gold‐catalyzed direct alkynylation of aromatic compounds (IV).
ChemInform Abstract: Effects of Phenols, Amines and Alcohols on the Reactivity of Triphenyltin Hydride Towards Alkyl Cinnamates.
Authors: Kalita Pankaj , Choudhury Diganta , Deka Dibakar Chandra 
Published: July 2012

AbstractThe effect of alcohols, amines, or phenols on the reactivity of triphenylstannane towards alkyl cinnamates is studied in the presence of AIBN as radical initiator.
ChemInform Abstract: Triterpenes Possessing an Unprecedented Skeleton Isolated from Hydrolyzate of Total Saponins from Gynostemma pentaphyllum.
Authors: Li Ning , Wu Chun‐Fu , Xu Xin‐Yue , Liu Zhen‐Yang , Li Xian , Zhao Yu‐Qing 
Published: July 2012

AbstractIsolation, structure determination and cytotoxicity of five novel triterpenes, gypensapogenins A—D, (I)—(IIb), as well as glucopyranoside of gypensapogenin D (IIc), are described.
ChemInform Abstract: Total Synthesis of Apigenin.
Authors: Wang Jin , Zhou Rong‐Guang , Wu Ting , Yang Tao , Qin Qi‐Xue , Li Ii , Yang Bo , Yang Jian 
Published: July 2012

AbstractAn efficient method for the synthesis of apigenin (VII), a trihydroxyflavone used as traditional medicine, is reported starting from commercially available phloroglucinol.
ChemInform Abstract: Coupling of Sterically Hindered Aldehyde with Fluorinated Synthons: Stereoselective Synthesis of Fluorinated Analogues of Salinosporamide A.
Authors: Chen Zeng‐Hao , Wang Bing‐Lin , Kale Andrew J. , Moore Bradley S. , Wang Ruo‐Wen , Qing Feng‐Ling 
Published: July 2012

AbstractThe syntheses of three fluorinated analogues of salinosporamide A are carried out.
ChemInform Abstract: Direct Synthesis of Anatase TiO2 Nanowires with Enhanced Photocatalytic Activity
Authors: Wu Hao Bin , Hng Huey Hoon , Lou Xiong Wen 
Published: July 2012

AbstractAnatase TiO2 nanowires are solvothermally synthesized in a gram‐scale from Ti(OBu)4 and a solution of LiOAc in DMF and AcOH (autoclave, 200 °C, 20 h) and characterized by FESEM, TEM, and powder XRD.
Fundamentals and Recent Developments in Filter Cake Washing
Authors: Wilkens Markus , Peuker Urs A. 
Published: July 2012

AbstractDie Filterkuchenwaschung ist ein Prozess zur Verbesserung der Qualität eines dispersen Feststoffs oder Erhöhung der Ausbeute an gelösten Wertstoffen während der Fest/Flüssig‐Trennung. Ziel hierbei ist es, die mit einer gelösten Substanz beladene Porenflüssigkeit durch eine möglichst reine Porenflüssigkeit auszutauschen. Als Waschmedien werden die reine Mutterflüssigkeit, eine zweite reine Flüssigkeit oder ein bei Prozessbedingungen kondensierbarer Dampf eingesetzt.
Synthesis, DNA and Photocleavage Studies of Ru(II) Polypyridyl Complexes: [Ru(dppz)(pyz)4](ClO4)2 and [Ru(dppz)(dmpyz)4](ClO4)2 Complexes
Authors: Pallavi Ponuganti , Nagababu Penumaka , Laxmareddy Kotha , Padmaja Naishadham , Satyanarayana Sirasani 
Published: July 2012

AbstractIn view of the growing interest for the synthesis of metal complexes and their interaction with DNA, we have synthesized and characterized two complexes containing ruthenium as metal center. The complexes are of the type [Ru(dppz)L4](ClO4)2 where L are biologically important ligands such as pyrazole and dimethylpyrazole. The characterization of these complexes is done by 1H NMR, 13C NMR, elemental analysis and mass spectroscopy. The interaction of these complexes with CT DNA was monitored and binding constants were determined using absorption and fluorescence spectroscopy. The mode of binding was found to be intercalative for both complexes and was determined using hydrodynamic viscosity studies. The complexes were further studied for photocleavage studies with supercoiled plasmid pBR322 DNA.
A G‐Quadruplex/Hemin Complex with Switchable Peroxidase Activity by DNA Hybridization
Authors: Shao Congying , Lu Na , Sun Dengming 
Published: July 2012

AbstractA hemin‐binding DNA G‐quadruplex (also known as a hemin aptamer or DNAzyme) has been previously reported to be able to enhance the peroxidase activity of hemin. In this work, we described a DNAzyme structure that had an effector‐recognizing part appearing as a single stranded DNA linkage flanked by two split G‐quadruplex halves. Hybridization of the single stranded part in the enzyme with a perfectly matched DNA strand (effector) formed a rigid DNA duplex between the two G‐quadruplex halves and thus efficiently suppressed the enzymatic activity of the G‐quadruplex/hemin complex, while the mismatched effector strand was not able to regulate the peroxidase activity effectively. With 2,2′‐azinobis(3‐ethylbenzthiazoline)‐6‐sulfonic acid (ABTS) as an oxidizable substrate, we were able to characterize the formation of the re‐engineered G‐quadruplex/hemin complex and verify its switchable peroxidase activity. Our results show that the split G‐quadruplex is an especially useful module to design low‐cost and label‐free sensors toward various biologically or environmentally interesting targets.
Differentiating between Models of Epothilone Binding to Microtubules Using Tubulin Mutagenesis, Cytotoxicity, and Molecular Modeling
Authors: Entwistle Ruth A. , Rizk Rania S. , Cheng Daniel M. , Lushington Gerald H. , Himes Richard H. , Gupta Mohan L. 
Published: July 2012

AbstractMicrotubule stabilizers are powerful antimitotic compounds and represent a proven cancer treatment strategy. Several classes of compounds in clinical use or trials, such as the taxanes and epothilones, bind to the same region of β‐tubulin. Determining how these molecules interact with tubulin and stabilize microtubules is important both for understanding the mechanism of action and enhancing chemotherapeutic potential, for example, minimizing side effects, increasing solubility, and overcoming resistance. Structural studies using non‐polymerized tubulin or stabilized polymers have produced different models of epothilone binding. In this study we used directed mutagenesis of the binding site on Saccharomyces cerevisiae β‐tubulin to analyze interactions between epothilone B and its biologically relevant substrate, dynamic microtubules. Five engineered amino acid changes contributed to a 125‐fold increase in epothilone B cytotoxicity independent of inherent microtubule stability. The mutagenesis of endogenous β‐tubulin was done in otherwise isogenic strains. This facilitated the correlation of amino acid substitutions with altered cytotoxicity using molecular mechanics simulations. The results, which are based on the interaction between epothilone B and dynamic microtubules, most strongly support the binding mode determined by NMR spectroscopy‐based studies. This work establishes a system for discriminating between potential binding modes and among various compounds and/or analogues using a sensitive biological activity‐based readout.
Patient decision aids for cancer treatment
Authors: Spiegle Gillian , Al‐Sukhni Eisar , Schmocker Selina , Gagliardi Anna R. , Victor J. Charles , Baxter Nancy N. , Kennedy Erin D. 
Published: July 2012

AbstractBACKGROUND:Although patient decision aids (pDAs) are effective, widespread use of pDAs for cancer treatment has not been achieved. The objectives of this study were to perform a systematic review to identify alternate types of decision support interventions (DSIs) for cancer treatment and a meta‐analysis to compare the effectiveness of these DSIs to pDAs.METHODS:The inclusion criteria for the study were: 1) all published studies using a randomized, controlled trial design, and 2) DSIs involving treatment decision‐making for breast, prostate, colorectal, and/or lung cancer. For this analysis, DSIs were classified as pDAs if: 1) one reported outcome measure mapped onto the International Patient Decision Aids Standards Collaboration effectiveness criterion, and 2) the DSI was evaluated relative to standard consultation. Random effects models were used to compare the effectiveness of pDAs relative to other identified DSIs for reported outcomes.RESULTS:A total of 71 studies were reviewed, and 24 met the inclusion criteria. Overall, there were no significant differences in knowledge, satisfaction, anxiety, or decisional conflict scores between pDAs and other DSIs.CONCLUSIONS:This study showed that the effectiveness of other DSIs, including question prompt lists and audiorecording of the consultation, is similar to pDAs. This is important because it may be that these less complex DSIs may be all that is necessary to achieve similar outcomes as pDAs for cancer treatment. Cancer 2013. © 2012 American Cancer Society.
The effect of treatment time in locally advanced cervical cancer in the era of concurrent chemoradiotherapy
Authors: Song Suisui , Rudra Sonali , Hasselle Michael D. , Dorn Paige L. , Mell Loren K. , Mundt Arno J. , Yamada S. Diane , Lee Nita K. , Hasan Yasmin 
Published: July 2012

AbstractBACKGROUND:This study sought to determine if treatment time impacts pelvic failure (PF), distant failure (DF), or disease‐specific mortality (DSM) in patients undergoing concurrent chemoradiotherapy (CCRT).METHODS:A retrospective review was performed of 113 consecutive eligible patients with stage IB2 to IIIB cervical cancer. All patients received whole‐pelvis radiation with concurrent chemotherapy and consolidative intracavitary brachytherapy (BT) to the cervix, followed by an external beam parametrial boost when appropriate. The effect of treatment time on PF, DF, and DSM was examined with univariate and multivariate analyses. Characteristics of patients with and without treatment prolongation were compared to explore reasons for treatment prolongation.RESULTS:The median time to completion of BT was 60 days, and the median time to complete all RT was 68 days. The 3‐year cumulative incidence of PF, DF, and DSM were 18%, 23%, and 26%, respectively. On multivariate analysis, time to completion of BT >56 days was associated with increased PF (hazard ratio, 3.8; 95% confidence interval, 1.2‐16; P = .02). The 3‐year PF for >56 days versus ≤56 days was 26% versus 9% (P = .04). Treatment time was not associated with DF or DSM. Treatment prolongation was found to be associated with delay in starting BT and higher incidence of acute grade 3/4 toxicities.CONCLUSIONS:In the setting of CCRT, treatment time >56 days is detrimental to pelvic control but is not associated with an increase in DF or DSM. To maximize pelvic control, we recommend completing BT in 8 weeks or less. Cancer 2013. © 2012 American Cancer Society.
Association of KRAS and EGFR mutations with survival in patients with advanced lung adenocarcinomas
Authors: Johnson Melissa L. , Sima Camelia S. , Chaft Jamie , Paik Paul K. , Pao William , Kris Mark G. , Ladanyi Marc , Riely Gregory J. 
Published: July 2012

AbstractBACKGROUND:Lung adenocarcinomas can be distinguished by identifying mutated driver oncogenes, including epidermal growth factor receptor (EGFR) and KRAS. Mutations in EGFR are associated with both improved survival as well as response to treatment with erlotinib and gefitinib. However, the prognostic significance of KRAS has not been evaluated in large numbers of patients and remains controversial. For the current report, the authors examined the association of EGFR and KRAS mutations with survival among patients with advanced lung adenocarcinomas.METHODS:Data were analyzed from patients with advanced lung adenocarcinomas who had known EGFR and KRAS mutation status evaluated between 2002 and 2009. The collected clinical variables included age, sex, Karnofsky performance status, smoking history, and treatment history. Overall survival from the diagnosis of advanced disease was analyzed using Kaplan‐Meier and Cox proportional hazard methods.RESULTS:In total, 1036 patients were evaluated, including 610 women (59%) and 344 never‐smokers (33%). The median patient age was 65 years (range, 25‐92 years), and the majority of patients (81%) had a Karnofsky performance status ≥80%. In multivariate analysis, EGFR mutations were associated with longer overall survival (hazard ratio, 0.6; P < .001), and KRAS mutations were associated with shorter survival (hazard ratio, 1.21; P = .048).CONCLUSIONS:KRAS mutations predicted shorter survival for patients with advanced lung adenocarcinomas. The presence of EGFR and KRAS mutations define distinct subsets of patients with lung adenocarcinomas and should be determined in patients when they are diagnosed with advanced disease. Clinical trial reports should include EGFR and KRAS mutation status along with other prognostic factors. Cancer 2013. © 2012 American Cancer Society.
Human pancreatic cancer fusion 2 (HPC2) 1‐B3: A novel monoclonal antibody to screen for pancreatic ductal dysplasia
Authors: Morgan Terry K. , Hardiman Karin , Corless Christopher L. , White Sandra L. , Bonnah Robert , Van de Vrugt Henry , Sheppard Brett C. , Grompe Markus , Cosar Ediz F. , Streeter Philip R. 
Published: July 2012

AbstractBACKGROUND.Pancreatic ductal adenocarcinoma is rarely detected early enough for patients to be cured. The objective of the authors was to develop a monoclonal antibody to distinguish adenocarcinoma and precancerous intraductal papillary mucinous neoplasia (IPMN) from benign epithelium.METHODS.Mice were immunized with human pancreatic adenocarcinoma cells and monoclonal antibodies were screened against a panel of archived pancreatic tissue sections, including pancreatitis (23 cases), grade 1 IPMN (16 cases), grade 2 IPMN (9 cases), grade 3 IPMN (13 cases), and various grades of adenocarcinoma (17 cases). One monoclonal antibody, human pancreatic cancer fusion 2 (HPC2) 1‐B3, which specifically immunostained adenocarcinoma and all grades of IPMN, was isolated. Subsequently, HPC2 1‐B3 was evaluated in a retrospective series of 31 fine‐needle aspiration (FNA) biopsies from clinically suspicious pancreatic lesions that had long‐term clinical follow‐up.RESULTS.HPC2 1‐B3 was negative in all 31 cases of chronic pancreatitis that were tested. In contrast, HPC2 1‐B3 immunostained the cytoplasm and luminal surface of all 16 well‐ to moderately differentiated pancreatic ductal adenocarcinomas. It demonstrated only weak focal staining of poorly differentiated carcinomas. All high‐grade IPMNs were found to be positive for HPC2 1‐B3. The majority of low‐grade to intermediate‐grade IPMNs were positive (66% of cases). Immunostaining a separate series of pancreatic FNA cell blocks for HPC2 1‐B3 demonstrated that the relative risk for detecting at least low‐grade dysplasia (2.0 [95% confidence interval, 1.23‐3.26]) was statistically significant (P = .002 by the Fisher exact test).CONCLUSIONS.To reduce the mortality of pancreatic cancer, more effective early screening methods are necessary. The data from the current study indicate that a novel monoclonal antibody, HPC2 1‐B3, may facilitate the diagnosis of early pancreatic dysplasia. Cancer (Cancer Cytopathol) 2013;121:37–46 © 2012 American Cancer Society.
A Reaction‐Based Colorimetric Fluoride Probe: Rapid “Naked‐Eye” Detection and Large Absorption Shift
Authors: Cheng Xiaohong , Li Shuang , Xu Guohua , Li Conggang , Qin Jingui , Li Zhen 
Published: July 2012

AbstractTaking advantage of both the well‐known azobenzene structure and the special fluoride‐promoted cleavage reaction of the SiO bond, a new ratiometric colorimetric probe (F‐1) toward the fluoride anion was designed and synthesized by using intramolecular charge transfer (ICT) as a signal mechanism. Upon the addition of F− ions, the probe displayed apparent color changes from colorless to deep blue, with a dramatic shift of the maximum absorption wavelength (≈230 nm). With the aid of UV/Vis measurements, the detection limit could be as low as 15 μM. The probe possessed much higher selectivity for fluoride over other common anions. Excitingly, by virtue of a “dipstick” approach, F‐1 could serve as colorimetric probe for convenient measurements, without the requirement of any additional equipment.
Spectroscopy and Photophysics in Cyclometalated RuII–Bis(bipyridyl) Complexes
Authors: Muro‐Small Maria L. , Yarnell James E. , McCusker Catherine E. , Castellano Felix N. 
Published: July 2012

AbstractA series of cyclometalated RuII coordination compounds of the general structural formula [Ru(bpy)2(C∧N)]PF6 {C∧N = 2‐phenylpyridine (1), 2‐(2,4‐difluorophenyl)pyridine (2), 2‐(4‐methoxyphenyl)‐5‐methylpyridine (3), benzo[h]quinoline (4); bpy = 2,2′‐bipyridine} have been synthesized, structurally and electrochemically characterized, and examined by using a battery of spectroscopic techniques. The combination of static and dynamic photoluminescence at room temperature and 77 K, resonance Raman spectroscopy, cyclic voltammetry, spectroelectrochemistry, and ultrafast transient absorption spectroscopy reveal that – although the nature of the cyclometalating ligand substantially affects the oxidation potential at the metal center – the lowest‐energy metal‐to‐ligand charge‐transfer excited state always retains pure Ru→bpy character across this series of molecules, and the cyclometalating subunit plays the role of ancillary ligand.
Combustion characteristics of cellulosic loose fibres
Authors: Ceylan Özgür , Alongi Jenny , Van Landuyt Lieve , Frache Alberto , De Clerck Karen 
Published: July 2012

SUMMARYThe aim of this paper is to study the combustion characteristics of loose fibrous cellulosic compounds through cone calorimeter measurements. The challenge in studying loose fibrous materials by cone calorimeter in a reproducible manner is met by optimizing various process parameters such as sample weight, heat flux and grid type. The method is validated using cotton fibres and fabrics with a range of flame retardant properties. Good correlations are obtained between the flame retardant content of samples and the heat release parameters for both the fibres and the fabrics. In addition, fibres from specific cotton cultivars showed statistically significant differences in heat release characteristics. This shows that valuable data concerning the combustion behaviour and the corresponding kinetics of loose fibrous compounds can be successfully gathered using a cone calorimeter. Thus, such data can be exploited to well define future fibre breeding programmes or fibre modification research. Copyright © 2012 John Wiley & Sons, Ltd.
WTC 9/11 twin towers research studies open panel discussion synopsis
Authors: Shields Jim 
Published: July 2012

ABSTRACTLead researchers of the three major research studies into the evacuation of and occupant evacuation behaviours in the WTC 9/11 Twin Towers in 2001 presented the results of their extensive investigations at the 4th International Symposium on Human Behaviour in Fire in Cambridge, UK, in 2009. Delegates attending the 4th Symposium were afforded, in a full programme session, the opportunity to discuss the results of these three major studies and to raise issues they considered pertinent. The open panel and delegate discussions were, with the knowledge of the participants, audio recorded in order to capture their flavour and essential content. The audio tapes were listened to by the author several times in order to distill what is considered their most useful content. This paper is not a verbatim account of the open ended panel/delegate discussions. It is merely the authors attempt to capture, archive and present as comprehensively as possible the views expressed and issues raised. Readers may wish to ponder if the issues raised have been or are they being addressed at all. Copyright © 2012 John Wiley & Sons, Ltd.