bluuebunny/crossref_metadata_2025_split huggingface dataset:
Does Intensivist Management of Organ Donors with Death by Neurological Criteria Result in Increased Organ Yield?
Authors: Atluri Sahaja , Bly Jacob D. , Terrill Danielle M. , Iliakova Maria , Mendez Marissa , Briggs Kayla , Neel Dustin R. , Johnson Scott S. , Whitt Steven P. , Olson Jody , Wang Xi , Kim Samuel , Moncure Michael , Menon Pooja , Atluri Anirudh , Markham Lori , Ott Melissa , Sander Scott , Vasquez Donald 
Published: June 2024

Abstract

Objective:
To determine whether intensivist management of donors increases the number of organs available for transplantation from organ donors with death by neurological criteria.
Setting:
The Midwest Transplant Network from January 2003 – October 2018.
Interventions:
Intensivist physicians engaged in donor management. Comparison of total number of donors, donor age, and organs transplanted of all organ types before and after intensivist management. Analysis using ANOVA and 2 sample t-test used to compare organ donations before and after intensivist management with a p-value of < 0.05 deemed statistically significant.
Results:
The number of organs transplanted showed a statistically significant increase after intensivist management for most organs. The number of organs transplanted increased by 38% (p-value = 0.009) and the number of donors increased by 28% (p-value = 0.026) following intensivist management. Donor age was significantly higher post-intensivist management (35.83 ± 18.79 vs. 38.89 ± 22.86, p-value = 0.0007). The number of organs transplanted per donor increased significantly after intensivist management (2.76 ± 1.82 vs 2.94 ± 1.89, p-value = 0.038).
Conclusion:
Our data suggest an increase in organs transplanted per donor may be associated with the involvement of a critical care specialist. Future research should explore the exact patient-centered implications.
Non-surgical treatment of residual periodontal pockets using sodium hypochlorite/amino acid gel and cross-linked hyaluronic acid - a 9-month pilot randomized controlled clinical trial
Authors: Benyei Laura , Friedmann Anton , Ostermann Thomas , Diehl Daniel 
Published: June 2024

Abstract

Objectives:
This pilot randomized controlled clinical trial compares the clinical outcome obtained in persistent periodontal pockets during 9-month follow-up of supportive periodontal step 4 treatment performed by either combining subgingival instrumentation with adjunctives or subgingival instrumentation alone.
Materials and methods:
Study protocol is registered under NCT06438354 at Clinicaltrials.gov. Patients seeking further therapy after completed step 2 non-surgical periodontal treatment underwent either repeated subgingival instrumentation with adjunctive application of sodium hypochlorite/amino acid gel and crosslinked hyaluronic acid (group A) or repeated subgingival instrumentation (group B). One calibrated investigator performed the treatment sequence in both groups accordingly. Subgingival instrumentation of the residual pockets was carried out under local anaesthesia using hand- and ultrasonic instruments, as well as air polishing in both groups. Patients were instructed to continue oral hygiene without any restriction. At 3-month re-evaluation treatment was repeated accordingly at sites with persistent 5mm probing depth and BoP+. Parameters clinical attachment level (CAL), probing depth (PD), gingival recession (GR), and bleeding on probing (BoP) were recorded at baseline (T1), 3- (T2) and 9-month (T3) post-op.
Results:
In total 52 patients (20 females and 32 males, mean age 58.4±2.4 years) presenting with 1448 sites were enrolled. Both groups exhibited homogeneity in terms of age, gender, smoking habit, initial number of sites, and BOP. At 9-month evaluation, PD reduction and CAL gain showed significant differences between the test and control group, favouring the adjunctive treatment. GR tended to exhibit more recovery in the test group compared to the control group. Although BOP frequency effectively reduced in both groups, there was no statistically significant difference between the two groups.
Conclusion:
Within the limits of the study, the present data indicates that, during subgingival instrumentation of persistent pockets, the adjunctive usage of sodium hypochlorite/amino acid gel and xHyA sufficiently improves the clinical outcome. The continuous improvement of CAL in association with the GR scores observed in group A, indicates that sites subjected to adjunctive treatment may exhibit regenerative response to treatment within the 9-month follow-up period.
Ultra-radical surgery versus standard-radical surgery for the primary cytoreduction of advanced epithelial ovarian cancer; Long-term tertiary center experiences
Authors: Aksan Alperen , Boran Nurettin , Coteli Ayse Sinem Duru , Ustun Yaprak 
Published: June 2024

Abstract

Purpose
To compare overall survival (OS) and morbidity outcomes in patients with advanced epithelial ovarian/tubal/peritoneal cancer undergoing standard-radical (SR) and ultra-radical (UR) surgical procedures based on NICE classification.
Materials and Methods
This retrospective study analyzed data from 282 patients with 2014 FIGO stage III-IV epithelial ovarian cancer operated on between January 2006 and January 2019. The study compared OS, progression-free survival (PFS), and morbidity between SR and UR surgeries. Parameters influencing OS, including preoperative, postoperative, and post-adjuvant chemotherapy CA-125 values, surgical procedures, post-surgical residual tumor, histopathological grade, and FIGO surgical stage, were assessed.
Results
Out of 282 patients, 256 met the inclusion criteria. SR surgery was performed in 48%, and UR surgery in 52%. The mean preoperative CA-125 value was 1200 ± 1914.83, decreasing to 240.32 ± 373.87 postoperatively. The mean follow-up period was 63.01 ± 47.56 months. UR surgery correlated with significantly higher postoperative complications (p < 0.001), histopathological grade (p = 0.023), FIGO stage (p < 0.001), three-year death rates, and overall mortality rates (p = 0.035). FIGO stage and total metastatic lymph nodes emerged as independent prognostic factors for overall and PFS.
Conclusion
In the treatment of epithelial ovarian cancer, evaluating the extent of the tumor before the surgery and showing maximal effort to minimize the residual tumor volume instead of applying UR procedures as the first choice seems to be the most important factor that can affect survival.
Assessment of the Accuracies of Multibeam Calibration Values and the Depth between Real-Time Kinematics and Precise Point Positioning
Authors: DEVOTE BASIL 
Published: June 2024

Abstract

Calibration of measurement equipment in the marine environment is critical in the attainment of expected accuracies. Multibeam device calibration is an important component of any hydrographic survey operations. The involves determining of the alignment angle between the multibeam sonar, motion sensor, and gyroscope, and accounts for the time delay (latency) between the sensors. Any errors in the positioning of the survey vessel will affect the multibeam calibration values and introduce systematic errors in the entire dataset. The main purpose of this work is to investigate the effects of horizontal and vertical positioning errors from two different GNSS positioning methods; Real-Time Kinematics (RTK) and Precise Point Positioning (PPP) methods, on the multibeam calibration values with varying depths. The approach involves the horizontal position of the pings as determined by integrating GNSS with inertial navigation systems using Kalman filtering techniques. The bathymetric depth determination is based on the ellipsoidal reference system using the EGM 2008 geoid model with a chart datum offset. The positioning and motion data were postprocessed to achieve the highest possible accuracy in the determination of the calibration parameters. The results show that the accuracy of the calibration value is a function of the positioning solutions. The RTK GNSS solution yields calibration value of \(-0.2{6}^{0}\pm 0.02, 2.5{6}^{0}\pm 0.14,\) and \(-1.4{4}^{0}\pm 0.07,\) for the roll, pitch and heading respectively, with a standard error of \(2.514{cm/m}^{2}\). The PPP GNSS solution gives a calibration value of\(-0.2{6}^{0}\pm 0.02, 2.{67}^{0}\pm 0.08,\) and \(-1.2{1}^{0}\pm 0.13,\) for roll, pitch and heading respectively, with a standard deviation of \(3.203{cm/m}^{2}\). The calibration values were used as systematic corrections in multibeam bathymetric surveys to improve the accuracy of the bathymetric data. The results show a deviation of 0.22m to 0.86m between the RTK derived bathymetric depth and the PPP derived bathymetric depth.
Timing and sequence of gingival penetrance of permanent teeth in Korean children : a retrospective cohort study
Authors: Kim Sung-Joo , Hyun Hong-Keun , Song Ji-Soo 
Published: June 2024

Abstract

Background
The timing and sequence of gingival penetrance are important for evaluating dental maturity and can be affected by racial differences and secular trends. This retrospective cohort study confirms the timing and sequence of gingival penetrance of permanent teeth in Korean children through panoramic radiography.
Methods
Analysis of 1,470 panoramic radiographs taken from January to December 2021 was conducted. Patients with systemic disease, maxillofacial deformity, pathologies in jaws, ectopic eruption, and tooth agenesis were excluded. Age, sex, and Demirjian developmental stage at gingival penetrance were evaluated. Comparisons were made between sex and between teeth with and without previous pulp treatment of primary antecedents. Furthermore, the sequence of gingival penetrance was investigated.
Results
The mandibular central incisor was the first to penetrate the gingiva at the age of 6.02 years. The maxillary teeth erupted later than mandibular teeth. Pulp treatment of primary molars accelerated gingival penetrance of permanent successors. Females experienced gingival penetrance earlier than males. All teeth, except for maxillary second molar, showed gingival penetrance at Demirjian developmental stage F. The sequence of gingival penetration was slightly different between arches.
Conclusion
The mandibular central incisor was the first teeth that showed gingival penetrance. Gingival penetrance usually occurs at Demirjian stage F.
Reconstructive surgical therapy of peri-implant defects with ribose cross-linked collagen matrix and crosslinked hyaluronic acid – a prospective case series
Authors: Friedmann Anton , Jung Rico , Bilhan Hakan , Ghawi-Begovic Hanan Al , Kauffmann Frederic , Diehl Daniel 
Published: June 2024

Abstract

Aims
This prospective case series investigated the efficacy of ribose-crosslinked collagen (RCLC) matrices functionalized by crosslinked hyaluronic acid (xHya) for reconstructive treatment of class I and III (b-c) peri-implantitis lesions in a transmucosal healing mode.
Materials and Methods:
Thirteen patients presenting with 15 implants were included. Upon flap reflection, the implants were thoroughly decontaminated employing glycine powder air polishing and adjunctive sodium hypochlorite. For defect augmentation, xHyA was administered to the bony defect walls, exposed implant surfaces, and the RCLC matrix before defect grafting. The full-thickness flap was readapted and sutured around the implant neck for transmucosal healing. Baseline and respective values at the 12 months post-op evaluation were recorded for the clinical parameters peri-implant probing depth (PPD) and bleeding on probing (BoP). Furthermore, two independent investigators analyzed radiographic changes in the defect area.
Results:
The initial mean PPD was 7.2±1.9 mm, and BoP was present in 63% of sites. After 12 months, PPD at the latest visit was 3.2±0.66 mm, which amounted to a respective 3.9±1.85mmreduction, while the BoP frequency dropped to 10% at all sites. Radiographic bone fill was accomplished for 62.8 % of the former defect area, accompanied by a mean MBL gain of 1.02mm around the treated implants.
Conclusions:
Within the limits of this case series, we conclude that the proposed treatment sequence substantially improved peri-implant defects and offered a simplified but predictive technique.
Ghrelin's Role in Sepsis Intestinal Damage: Ferroptosis and Barrier Study
Authors: Hou Qiliang , Dou Zhimin , Zhu Lei , Li Bin 
Published: June 2024

Abstract

Objective: This study investigates the therapeutic efficacy of ghrelin in alleviating sepsis-induced intestinal damage, focusing on its potential to inhibit ferroptosis and protect intestinal barrier integrity.
Methods: Employing a cecal ligation and puncture model in C57BL/6 mice, we examined the impact of ghrelin and Ferrostatin-1 on bacterial load, intestinal morphology, systemic inflammation, oxidative stress, and ferroptosis markers. Our methodology included histopathological evaluations, cytokine profiling, oxidative stress assays, and analysis of ferroptosis indicators.
Results: Treatment with ghrelin significantly reduced bacterial proliferation, mitigated intestinal damage, and decreased systemic inflammation. Comparable outcomes were observed with Fer-1 treatment. Both interventions restored intestinal barrier functions, modulated inflammatory responses, and attenuated oxidative stress, indicating a suppression of the ferroptosis pathway.
Conclusion: Ghrelin exhibits a protective role in sepsis-induced intestinal injury, likely through the inhibition of ferroptosis. This mechanism underscores ghrelin's therapeutic potential in sepsis management, suggesting avenues for further clinical exploration.
Assessing the role of non-state actors in health service delivery and health system resilience in Myanmar
Authors: Than KK , Bertone Maria Paola , La T , Witter Sophie 
Published: June 2024

Abstract

Background
Due to the weaknesses of the public health system and its low reach, especially in border areas, provision of health services by non-state actors (NSAs) has historically played an important role in Myanmar. NSAs include local and international NGOs and civil society organisations (CSOs), but also Ethnic Health Organisations (EHOs) in the border areas, as well as the private (for profit) sector. This study aims to understand the changing role of NSAs in the shifting political environment of Myanmar between 2010 and 2022, and to explore their contribution to health system resilience.
Methods
Our study includes three main components: a documentary review (n = 22), key informant interviews (KIIs) at central level (n = 14) and two township-level case studies (13 KIIs, 4 FGDs). Mostly qualitative data were collected in 2022 and synthesized, using a health system resilience framework to structure the analysis.
Results
During the transition period (2010–2014) and the new political era (2015–2020), while the country gradually transitioned to a democratic system, the government increasingly recognized NSAs. Initially, engagement with NSAs remained focused on disease-specific activities and government oversight was limited, but later it expanded to health system strengthening, including the start of a “convergence” with ethnic health systems. Progress was relatively slow, but defined by a clear vision and plans. The military coup of February 2021 brought a halt to this progress. Collaboration between government and NSAs was interrupted, and NSAs restored previous practices and parallel systems. Initially, most health service provision stopped, but with time coping strategies emerged, which showed the capacity of NSAs to absorb the shocks (focusing on basic services; using informal communication channels; maintaining buffer stocks of supplies) and adapt (changing modes of delivery and supply chains, and adjusting HRH training).
Conclusions
The study highlights the role of NSAs during crises, and provides insights on how the resilience capacities built over time by NSAs to provide services in adverse circumstances have informed the response to the latest crisis. While strategies of absorption and adaptation are noted in the study, we did not identify any transformation strategy – which might indicate the difficulty of NSAs to introduce radical changes when subjected to multiple shocks and a hostile political environment.
YeeE-like bacterial SoxT proteins mediate sulfur import for oxidation and signal transduction
Authors: Dahl Christiane , Li Jingjing , Göbel Fabienne , Hsu Hsun , Koch Julian , Hager Natalie , Flegler Wanda , Tanabe Tomohisa 
Published: June 2024

Abstract

Many sulfur-oxidizing prokaryotes oxidize sulfur compounds through a combination of initial extracytoplasmic and downstream cytoplasmic reactions. Facultative sulfur oxidizers adjust transcription to sulfur availability. While sulfur-oxidizing enzymes and transcriptional repressors have been extensively studied, sulfur import into the cytoplasm and how regulators sense external sulfur are poorly understood. Addressing this gap, we show that SoxT1A and SoxT1B, which resemble YeeE/YedE-family thiosulfate transporters and are encoded alongside sulfur oxidation and transcriptional regulation genes, fulfill these roles in the Alphaproteobacterium Hyphomicrobium denitrificans. SoxT1A mutants are sulfur oxidation-negative despite high transcription levels of sulfur oxidation genes, showing that SoxT1A delivers sulfur to the cytoplasm for its further oxidation. SoxT1B serves as a signal transduction unit for the transcriptional repressor SoxR, as SoxT1B mutants are sulfur oxidation-negative due to low transcription unless SoxR is also absent. Thus, SoxT1A and SoxT1B play essential but distinct roles in oxidative sulfur metabolism and its regulation.
Impacts of clinical psychiatric posting experience on specialization intention and associated factors among Nursing Science students
Authors: Stanley NJAKA , Hassan INTAN Idiana Binti , Nwedu AARON Beryl , Bakar RAISHAN Shafini Binti , Cheng KUEH Yee 
Published: June 2024

Abstract

Background
Globally, there is increasingly high prevalence of mental disorders across all age groups and social classes with more being projected by 2030 but without commensurate resources for mental health care delivery especially in developing countries.
Purpose
This study assessed the career choice in psychiatry before and after clinical psychiatric posting and associated factors among nursing students.
Methods
A prospective cohort research design was used and data collected using ATP, MICA-4 and researcher developed questionnaires on career choice in pre and post clinical posting approach. A sample size of 800 students (400 before posting and another 400 students after posting) were involved in the study. Data were coded, cleaned and analyzed using SPSS version 26. McNemar Test was used to determine the effects of clinical posting on career choices in psychiatry. Simple and multiple logistic regressions were used to analyze data on determinants of career choices in psychiatry. The hypotheses were tested at p-value < 0.05.
Results
Psychiatric and mental health nursing was one of the least preferred specialty with 21(6%) respondents who showed interest before clinical posting and 25(7.1%) after the posting. Commonly preferred specialty choice was pediatric nursing (20.5%), community health nursing (17.1%) and midwifery (17.7%). McNemer test showed no statistically significant differences in choice of psychiatry before and after clinical posting. Key determinants of career choices were interest in psychiatry (AOR = 16.06(95% CI = 1.10, 129.01)P = 0.009), interest in community services (AOR = 4.01(95% CI = 1.32, 12.20)P = 0.014), family influence(AOR = 13.76(95% CI = 1.74, 108.57)p = 0.013) and job satisfaction(AOR = 0.10(95% CI = 0.03, 0.26)P < 0.001).
Conclusion
the researcher therefore concluded that key factors are responsible for the none choice of career in psychiatry and such should be put into consideration when planning measures to improve acceptability of the specialty area among the students..
Surgical and Non-Surgical Predictors of long term Erectile Function after Robot Assisted Radical Prostatectomy
Authors: Tillier CN , Cox IL , Hagens MJ , Nicolai MPJ , Muilekom HAM van , Leeuwen PJ van , de Poll-Franse LV van , Poel HG van der 
Published: June 2024

Abstract

Purpose
Robotic-assisted radical prostatectomy (RARP) impairs erectile function (EF) due to the surgical procedure and non-surgical factors. Non-surgical factors may contribute to recovery of erectile function (EFR) after RARP. This study assessed the role of non-surgical factors including physical activity in baseline EF and EFR after prostatectomy.
Methods
Patient Reported Measure Outcomes questionnaires from patients with localized prostate carcinoma who underwent a RARP with a postoperative follow up (FU) of 3 years. EFR was defined as at least 70% EF recovery of baseline IIEF-EF. Physical activities was defined as no activity at all, once a week and ≥ 2 a week.
Results
In total 804 patients were included. At baseline, age, lower urinary tract symptoms (LUTS), having a partner and former smoking were significantly associated (p < .001) of EF. Postoperatively, the extent of nerve sparing and baseline EF were strongly associated with EFR (p < .001). Physical activity ≥ 2 a week predicted EF but only beyond 6 months of FU (p = .005, p = .028 and p = .007 at 1, 2 and 3 year FU respectively). Comorbidities, BMI and the use of medications known to affect EF were not predictive of EFR.
Conclusions
Age, LUTS, having a partner and former smoking were baseline associated with EF prior to RARP. Baseline EF and extent of nerve sparing jointly predicted EFR. Intensive physical activity was an independent predictor of EFR beyond the first year after RARP. Our findings suggests that besides clinical factors, lifestyle may also play a role in recovery of erectile function.
A flexible belt conveying system: self-organizing ofmicro-conveyor cells
Authors: Fang Yuanjie , Wang Ziqing , Xu Bing , Rui Zhaobiao , Li Dan 
Published: June 2024

Abstract

Conveyor systems play an important role in material transportation in industries. For the problems of lacking belt conveying system for flexible organization and Automated Guided Vehicles (AGV) transportation system,this paper proposes a flexible architecture micro-conveyor cells self-organized system into a belt conveying system. This architecture combines the advantages of both AGVs transportation system and belt conveying system well. First, this paper give the definitions of micro-conveyor cell and micro-conveyor self-organization architecture. Then, the path segmentation and secondary programming algorithms of micro-conveyor cell and self-organization are given, and the theorem of path segmentation without secondary programming is proved.Based on the architecture, the mechanical structure of micro-conveyor with 2 levels belt conveyor, which satisfies the definition of micro-conveyor and made into prototype machine further, is designed. Finally, the above algorithms and theorem are verified by MATLAB simulation experiments and the experimental results show its effectiveness.