bluuebunny/crossref_metadata_2025_split huggingface dataset:
Flexible Anti‐Counterfeiting Circularly Polarized Luminescent Elastomer from Supramolecular Polyurethanes
Authors: Duan Huimin , Zhao Jinbiao , Li Shuli , Qi Dongming , Li Jiawei 
Published: June 2024

AbstractSupramolecular polymers with circularly polarized luminescence (CPL) have promoted future intelligence development of polymer‐based materials for flexible display. However, preparing polymer‐based CPL materials with simultaneous enhanced luminescence dissymmetry factor (|glum|) and mechanical performance for industrial applications remains challenging. This work develops an eco‐friendly preparation method for preparing CPL elastomers from supramolecular polyurethanes bearing chiral fluorescent S (or R)‐1,1′‐Bi(2‐naphthol) (BINOL) groups in a solvent‐free system. Surprisingly, a polymer system containing 0.0028 mol% of chiral BINOL unit is sufficient to emit the significant CPL‐activity with a |glum| value of 2.30 × 10−2, appear a good mechanical toughness of 56.28 ± 3.9 MJ·m−3, thereby exhibit multiple flexible anti‐counterfeiting behaviors. The long‐range ordered microphase arrangement in polyurethanes is the key to improving both mechanical properties and |glum|. This is attributed to in‐situ additive polymerization of BINOL‐based isocyanate prepolymer and macromolecular polyols induced helical supramolecular structure, afforded solid‐state films with flexibility and chiral amplification. Furthermore, these results from Circular dichroism, CPL, Fourier transform infrared, X‐ray diffraction analyses, and atomic force microscope confirm the formation of long‐range ordered microphase arrangement through the synergistic effect of hydrogen bonding and π–π interactions. This work offers significant insights into the construction of CPL elastomers for developing novel flexible display materials.
Exploring consumption profiles, consumer experience and quality claims of Canary Islands' cider (Spain): A multidimensional analysis
Authors: Parga Dans Eva , Alonso González Pablo , Otero Enríquez Raimundo , Sáenz Navajas María‐Pilar 
Published: June 2024

AbstractThe exponential expansion of the global cider market positions it as a viable alternative to traditional choices such as wine and beer. Nevertheless, there exists a paucity of research examining the various factors influencing consumer interest in cider. This article undertakes an analysis of the cider consumption experience, with a specific focus on consumer preferences related to distinct quality attributes, encompassing factors like brand, organic certification, and protected designations of origin (PDO). This analysis also takes into consideration the socio‐demographic profile, frequency of consumption, and willingness to pay (WTP). Our study concentrates on the Canary Islands in Spain, an area where no formal certification system yet exists to differentiate locally produced cider in the market. Our data collection methodology encompassed face‐to‐face surveys administered to a probabilistic sample of 1000 respondents in the Canary Islands. The results demonstrate that consumers who place emphasis on quality attributes such as commercial brands, organic certification, and PDOs, tend to assign value to various cognitive aspects of the product. Conversely, those who do not prioritize these quality attributes tend to emphasize the affective dimension of the product and the specific consumption occasions. Additionally, consumers who accord the highest importance to PDOs exhibit a WTP a premium price. The findings of this study hold valuable implications for policymakers and cider manufacturers, aiding them in identifying opportunities for the promotion of Canary Islands cider, both within the local market and on a global scale. [EconLit Citations: A14 Sociology of Economics, Q00 Agricultural and Natural Resource Economics, Environmental and Ecological Economics: General].
Ixazomib plus daratumumab and dexamethasone: Final analysis of a phase 2 study among patients with relapsed/refractory multiple myeloma
Authors: Delimpasi Sosana , Dimopoulos Meletios A. , Straub Jan , Symeonidis Argiris , Pour Luděk , Hájek Roman , Touzeau Cyrille , Bhanderi Viralkumar K. , Berdeja Jesus G. , Pavlíček Petr , Matous Jeffrey V. , Robak Pawel J. , Suryanarayan Kaveri , Miller Alison , Villarreal Miguel , Cherepanov Dasha , Srimani Jaydeep K. , Yao Huilan , Labotka Richard , Orlowski Robert Z. 
Published: June 2024

AbstractNovel therapies have improved outcomes for multiple myeloma (MM) patients, but most ultimately relapse, making treatment decisions for relapsed/refractory MM (RRMM) patients increasingly challenging. We report the final analysis of a single‐arm, phase 2 study evaluating the oral proteasome inhibitor (PI) ixazomib combined with daratumumab and dexamethasone (IDd; NCT03439293). Sixty‐one RRMM patients (ixazomib/daratumumab‐naïve; 1–3 prior therapies) were enrolled to receive IDd (28‐day cycles) until disease progression/unacceptable toxicity. Median age was 69 years; 14.8% of patients had International Staging System stage III disease; 14.8% had received three prior therapies. Patients received a median of 16 cycles of IDd. In 59 response‐evaluable patients, the overall response rate was 64.4%; the confirmed ≥very good partial response (VGPR) rate (primary endpoint) was 30.5%. Rates of ≥VGPR in patient subgroups were: high‐risk cytogenetics (n = 15, 26.7%), expanded high‐risk cytogenetics (n = 24, 29.2%), aged ≥75 years (n = 12, 16.7%), lenalidomide‐refractory (n = 21, 28.6%), and prior PI/IMiD therapy (n = 58, 31.0%). With a median follow‐up of 31.6 months, median progression‐free survival was 16.8 months (95% confidence interval: 10.1–23.7). Grade ≥3 treatment‐emergent adverse events (TEAEs) occurred in 54.1% of patients; 44.3% had serious TEAEs; TEAEs led to dose modifications/reductions/discontinuations in 62.3%/36.1%/16.4%. There were five on‐study deaths. Any‐grade and grade ≥3 peripheral neuropathy occurred in 18.0% and 1.6% of patients. Quality of life was generally maintained throughout treatment. IDd showed a positive risk‐benefit profile in RRMM patients and was active in clinically relevant subgroups with no new safety signals.
Uncovering the impact of alcohol on internal organs and reproductive health: Exploring TLR4/NF‐kB and CYP2E1/ROS/Nrf2 pathways
Authors: Kong Eason Qi Zheng , Subramaniyan Vetriselvan , Lubau Natasha Sura Anak 
Published: June 2024

AbstractThis review delves into the detrimental impact of alcohol consumption on internal organs and reproductive health, elucidating the underlying mechanisms involving the Toll‐like receptor 4 (TLR4)/Nuclear factor kappa light chain enhancer of activated B cells (NF‐kB) pathway and the Cytochrome P450 2E1 (CYP2E1)/reactive oxygen species (ROS)/nuclear factor erythroid 2‐related factor 2 (Nrf2) pathways. The TLR4/NF‐kB pathway, crucial for inflammatory and immune responses, triggers the production of pro‐inflammatory agents and type‐1 interferon, disrupting the balance between inflammatory and antioxidant responses when tissues are chronically exposed to alcohol. Alcohol‐induced dysbiosis in gut microbes heightens gut wall permeability to pathogen‐associated molecular patterns (PAMPs), leading to liver cell infection and subsequent inflammation. Concurrently, CYP2E1‐mediated alcohol metabolism generates ROS, causing oxidative stress and damaging cells, lipids, proteins, and deoxyribonucleic acid (DNA). To counteract this inflammatory imbalance, Nrf2 regulates gene expression, inhibiting inflammatory progression and promoting antioxidant responses. Excessive alcohol intake results in elevated liver enzymes (ADH, CYP2E1, and catalase), ROS, NADH, acetaldehyde, and acetate, leading to damage in vital organs such as the heart, brain, and lungs. Moreover, alcohol negatively affects reproductive health by inhibiting the hypothalamic–pituitary‐gonadal axis, causing infertility in both men and women. These findings underscore the profound health concerns associated with alcohol‐induced damage, emphasizing the need for public awareness regarding the intricate interplay between immune responses and the multi‐organ impacts of alcohol consumption.
2‐Methylimidazole‐1‐(N‐tert‐octyl)sulfonimidoyl Fluoride: A Bench‐Stable Alternative to SOF4 as Precursor to N,O‐Substituted S(VI) Compounds
Authors: Lional Natassa , Miloserdov Fedor M. , Zuilhof Han 
Published: June 2024

AbstractS(VI) compounds with multiple N or O substituents are often difficult to make and several crucial routes, such as multimodal SuFEx (Sulfur (VI) Fluoride Exchange) chemistry, rely on the highly useful but hazardous SOF4 gas. Safety issues and inaccessibility of SOF4 strongly hamper the developments of these organic compounds. Here we describe the synthesis and applications of 2‐methylimidazole‐1‐(N‐tert‐octyl)sulfonimidoyl fluoride (ImSF), a novel bench‐stable analogue of SOF4. ImSF is synthesized on a gram scale via a double fluorination of t‐OctNSO. We show ImSF can undergo substitution reactions with phenols and amines, which lead to sulfurimidates and sulfuramidimidates, respectively, the intrinsically chiral analogous of medicinally relevant sulfates and sulfamates in which an S=O moiety is replaced by S=NR unit. Finally we demonstrate that such substitutions can occur enantiospecifically, providing the first entry to chiral sulfurimidates and sulfuramidimidates.
Zwitterionic Energetic Materials: Synthesis, Structural Diversity and Energetic Properties
Authors: Bhatia Prachi , Pandey Krishna , Kumar Dheeraj 
Published: June 2024

AbstractZwitterionic compounds are an emergent class of energetic materials and have gained synthetic interest of many in the recent years. Due to their better packing efficiencies and strong inter/intramolecular electrostatic interactions, they often ensue superior energetic properties than their salt analogues. A systematic review from the perspective of design, synthesis, and physicochemical properties evaluation of the zwitterionic energetic materials is presented. Depending on the parent ring(s) used for the synthesis and the type of moieties bearing positive and negative charges, different classes of energetic materials, such as primary explosives, secondary explosives, heat resistant explosives, oxidizers, etc., may result. The properties of some of the energetic zwitterionic compounds are also compared with analogous energetic salts. This review will encourage readers to explore the possibility of designing new zwitterionic energetic materials.
Unveiling Route for the Synthesis of Tröger's Bases Through Azide Rearrangement
Authors: Jaithum Kanokwan , Tummatorn Jumreang , Thongsornkleeb Charnsak , Ruchirawat Somsak 
Published: June 2024

AbstractThis study introduces a novel method for producing Tröger's bases by utilizing the rearrangement chemistry of benzyl azide. This method offers a convenient and adaptable pathway for synthesizing these important molecular structures with potential for further advancements. By reacting benzyl azide derivatives with TfOH under the presence of water, this process generates iminium ion, formaldehyde, and aniline intermediates in situ. Notably, this conversion is reversible under acidic conditions, allowing for the regeneration of the iminium ion and ultimately leading to the formation of the desired Tröger's base product. Additionally, this method could decrease the risk of exposure to an excess amount of formaldehyde.
Interphase Design of LiNi0.6Mn0.2Co0.2O2 as Positive Active Material for Lithium Ion Batteries via Al2O3 Coatings Using Magnetron Sputtering for Improved Performance and Stability
Authors: Javed Atif , Makvandi Ardavan , Demelash Feleke , Adhitama Egy , Heidrich Bastian , Peterlechner Martin , Wilde Gerhard , Winter Martin , Börner Markus 
Published: June 2024

AbstractInvited for this month's cover picture is the group of Markus Börner at MEET Battery Research Center from the University of Münster. The cover picture depicts skiers (NMC active material) competing in a skiing race (electrochemical stability). RF‐magnetron‐based homogenously coated NMC outperformed inhomogeneously coated and uncoated ones due to better protection. Read the full text of the article at 10.1002/batt.202300580
An economic analysis of bamboo plantations and feedstock delivered cost in the Southern US for the manufacturing of fiber‐based bioproducts
Authors: Vivas Keren A. , Vera Ramon E. , Phillips Richard B. , Forfora Naycari , Azuaje Ivana , Zering Kelly , Chang Hou‐Min , Delborne Jason , Saloni Daniel , Dasmohapatra Sudipta , Barbieri Carla , Venditti Richard A. , Marquez Ronald , Gonzalez Ronalds 
Published: June 2024

AbstractBamboo, recognized for its rapid growth, high yield, and fiber performance is prominent in the fiber‐based bioproduct industry. However, the absence of US industrial bamboo plantations for fiber production necessitates reliance on imports or locally manufactured products using imported bamboo fibers, predominantly from China. This study evaluates the economic viability of cultivating bamboo in the Southern US for fiber production, with a case study on hygiene tissue products. The supply‐chain analysis was assessed to calculate bamboo chips' minimum selling price (MSP) at the farm gate for an 8% internal rate of return (IRR). The MSP, influenced primarily by land rental costs, ranges from USD 48 to 55 per bone‐dry metric ton (BDt). Despite an initial establishment cost of ~USD 2 000 ha−1 and profitability by year 5, bamboo is a viable, long‐term fiber alternative. Successful bamboo cultivation in the US could lead to a more sustainable implementation of alternative non‐wood fibers for hygiene tissue applications.
Über die Notwendigkeit zur Präzisierung der Auszählung von Luftporen im Beton
Authors: Mercedes Kind Vanessa , Kränkel Thomas , Dehn Frank 
Published: June 2024

AbstractDie Bestimmung von Luftporenkennwerten im Festbeton erfolgt üblicherweise durch eine mikroskopische Analyse, bei der die Luftporen auf einer geschliffenen Betonoberfläche manuell oder automatisch ausgezählt werden. Das manuelle Verfahren ist zeitintensiv und unterliegt subjektiven Einflüssen, während das automatische Verfahren aufwendige Kontrastierungen erfordert, um zuverlässige Ergebnisse zu erzielen. Obwohl allgemein bekannt ist, dass beide Verfahren erheblichen Streuungen unterliegen, wurden die maßgebenden Einflussfaktoren bisher nur wenig erforscht. Darüber hinaus gibt es bislang nur wenige Präzisionsdaten zum Mikroluftporengehalt A300, einem maßgebenden Kennwert zur Beurteilung des Frostwiderstands. Diese Veröffentlichung untersucht die o. g. Aspekte anhand eines Ringversuchs zur Luftporenauszählung nach DIN EN 480‐11, an dem sieben manuell und eine automatisch auszählende Prüfstelle teilnahmen. Die Ergebnisse zeigen, dass die aktuellen Prüfvorschriften präzisiert werden müssen, um eine einheitliche Vorgehensweise und damit vergleichbare Prüfergebnisse zu gewährleisten. Zudem wird aufgezeigt, dass die Grenzwerte für den Mindestluftgehalt im Frischbeton bindemittel‐ und verfahrensabhängig spezifiziert werden sollten.
Educational impact of Metaverse learning environment for engineering mechanics dynamics
Authors: Sidhu Manjit S. , Mousakhani Sara , Lee Chen K. , Sidhu Kirandeep K. 
Published: June 2024

AbstractMechanics dynamics course is challenging for mechanical engineering students. Strong abilities in abstract thinking, reasoning, and problem‐solving are prerequisites for this course. Technology advancements in Industrial Revolution 4.0 have brought about significant changes in engineering education, and traditional teaching methods may no longer be sufficient to prepare students for the requirements of this industrial revolution. Relating to all Internet technologies, the Metaverse is an emerging environment that allows immersive interactive experiences to enhance comprehension. Combining Metaverse with constructivist learning, students can engage in engineering tasks and receive real‐time feedback for deeper understanding. Education 5.0 emphasizes the use of new applications and technology to provide more humanized education, with an emphasis on students' social and emotional growth and solutions that improve life in society. However, since the Metaverse learning environment is still in its infancy, more empirical research is required regarding the application of the Metaverse environment using a constructivist approach to facilitate teaching and learning in engineering, particularly in the setting of mechanics dynamics. This research proposal aims to investigate and design a conceptual framework for the Metaverse environment as an additional learning aid in mechanical engineering education. The research findings could enhance the quality of mechanical engineering education, which is in line with the current Malaysia education blueprint that is, the incorporation of new educational technology aids and interventions. Additionally, the findings could provide new insights into the design of engineering curricula teaching practices and the Malaysian Science, Technology, Innovation, and Economy policy of providing new educational platforms that is, to nurture a creative society and a skilled workforce.
Prognosis of unresected versus resected early‐stage pulmonary carcinoid tumors ≤3 cm in size: A population‐based study
Authors: Li Xiongfei , Fan Fanfan , Jia Xuewang , Yang Lingqi , He Jinling , Tang Quanying , Cao Weibo , Che Ji , Xu Song 
Published: June 2024

AbstractPurposeThe observation‐based prognosis, rather than resection, for small carcinoid tumors is still unclear. This lack of clarity has important implications for counseling elderly patients or patients for whom surgical resection poses a high risk. This study compared the outcomes of observation and surgical resection in patients with pulmonary carcinoid (PC) tumors ≤3 cm in size without metastasis.MethodsData of patients with PC tumors with ≤3 cm in diameter and without lymph node and distant metastases were retrieved from Surveillance, Epidemiology, and End Results (SEER) registry. To reduce the inherent bias of retrospective studies, propensity score matching analysis was performed. Overall survival (OS) and lung carcinoid‐specific survival (LCSS) were analyzed using Kaplan–Meier plots. Multivariate analysis was used to determine predictors of LCSS in different size subgroups.ResultsIn total, 4552 patients with early‐stage PCs ≤3 cm in diameter, including 435 (9.56%) who were observed and 4117 (90.44%) treated by surgery, were recruited. Patients with surgery had significantly better OS and LCSS than those who were observed. However, patients with observation had comparable LCSS to those with surgery for PCs with tumor diameters ≤1 cm. Multivariate analysis indicated that surgical resection was an independent prognostic factor for LCSS in 1 cm < tumors ≤2 cm, and 2 cm < tumors ≤3 cm groups, but not for tumors ≤1 cm in diameter.ConclusionSurgical resection of small PCs is associated with a survival advantage over observation. However, for early PCs ≤1 cm in diameter, observation may be considered in patients with high risk for surgical resection.
A clinical dilemma: Performing or avoiding root instrumentation in the treatment of the acute phase of endodontic‐periodontal lesions? A case report
Authors: Pace Riccardo , Di Gianfilippo Riccardo , Franceschi Debora , Pini Prato GiovanPaolo 
Published: June 2024

AbstractBackgroundThis study presents the diagnois, management, and tissue response to an acute periodontal lesion with deep pocketing affecting a maxillary central incisor in a young patient devoid of caries or a history of periodontitis.MethodsClinical and radiographic examinations facilitated the diagnosis of the pathology as an endoperiodontal lesion (EPL) with root damage, exhibiting supracrestal invasive root resorption. Orthograde endodontic therapy was employed to decontaminate and seal the endodontic space. The resorptive site was treated through the endodontic access, debrided, and sealed. No periodontal therapy (surgical or nonsurgical) was performed. No mechanical instrumentation was performed within the pocketed root surface.ResultsAt 6‐month and 1‐year follow‐ups after endodontic therapy the periodontium displayed a physiologically healthy condition without pus or inflammation, exhibiting a circumferential probing depth of 2 mm, and absence of tooth mobility. These favorable outcomes persisted throughout a 4‐year follow‐up period.ConclusionsThe spontaneous healing of pocketing and abscess occurred without mechanical root instrumentation following endodontic therapy and treatment of external invasive root resorption in an EPL.Key Points
Accurate diagnosis and identification of relevant etiologic factors are pivotal for effectively managing endodontic‐periodontal lesions. Once a diagnosis is established, the therapy focuses on eliminating the primary cause, followed by a subsequent diagnostic phase after healing. The definitive understanding of the diagnosis and etiology of endodontic‐periodontal lesions often becomes clear in retrospect, based on the outcomes of the therapy.
When probing acute periodontal lesions, deep probing depths may occur without permanent loss of periodontal attachment. If the acute lesion was not induced by a periodontal cause and if no periodontal etiology arises secondarily, resolving the primary cause of the endoperiodontal lesion can lead to the spontaneous resolution of the pocketing. This results in spontaneous healing of periodontium without the need for intentional periodontal therapy.
A clinical dilemma arises when considering periodontal treatment during the acute inflammatory phase of endo‐periodontal pathology. It is advisable to refrain from mechanical root instrumentation particularly if a clear periodontal cause is not apparent, to prevent from iatrogenic damage to periodontal fibers and the potential risk of gingival recessions. However, this does not imply avoiding periodontal therapy entirely for every case. Rather, it is recommended to delay the decision on root instrumentation until a new diagnostic phase is conducted following the healing of the endodontic etiology.
Factors affecting career motivation of recent graduates: Career adaptability as a mediator
Authors: Lin Mei‐Hua , Lim Pek Kei , Azalea Alia , Lee Michelle Chin Chin 
Published: June 2024

AbstractCareer adaptability is a key resource for adapting to and transitioning into careers. However, gaps are found in the research on career adaptability. This study examined whether proactive personality, future‐proofing, psychological capital, and technology readiness predict career adaptability and whether career adaptability mediates the relationship between these predictors and career motivation. The data from 455 Malaysian recent university graduates found career adaptability to mediate the relationship between all predictors and career motivation. They positively affected career adaptability, which in turn, increased career motivation. While, in the presence of predictors of individual characteristics, technology readiness was not significant in predicting career adaptability, it predicted career motivation. The study recommends enhancing career adaptability and personal traits through interventions and training, stressing the importance of integrating technology into higher education to promote career motivation and readiness for adapting to the future work environment.