bluuebunny/crossref_metadata_2025_split huggingface dataset:
Second salvage surgery for re‐recurrent oral cavity and oropharynx carcinoma
Authors: Agra Ivan Marcelo Gonçalves , Filho João Gonçalves , Martins Everton Pontes , Kowalski Luiz Paulo 
Published: February 2010

AbstractBackground.Salvage surgery is considered the best treatment approach for patients with recurrent oral carcinoma. Unfortunately, 50% to 60% of the patients who undergo salvage surgery will develop further locoregional recurrence, and they are not usually considered for further treatment. Our aim in this study was to report our experience with a second salvage surgery for selected patients with re‐recurrent oral cavity and oropharyngeal squamous cell carcinoma (SCC).Methods.Forty‐one patients underwent a second salvage surgical procedure, with curative intention for re‐recurrent oral cancer. The surgical treatment used was wide local resection in 34 cases, neck dissection in 9 cases, and isolated neck dissection in 7 cases.Results.Cancer‐specific survival (CSS) rate in 3 years was at 20%. Patients with re‐recurrence in <6 months presented 3‐year CSS null, whereas patients with re‐recurrence after 6 months presented 3‐year CSS of 32.3% (p = .007).Conclusion.Second salvage surgery can be considered a potentially curative therapeutic approach for a selected group of patients with re‐recurrent oral SCC. The disease‐free interval was the main clinical factor associated with the prognosis. © 2010 Wiley Periodicals, Inc. Head Neck, 2010
Better understanding tumor–host interaction in head and neck cancer to improve the design and development of immunotherapeutic strategies
Authors: Badoual Cécile , Sandoval Federico , Pere Helene , Hans Stephane , Gey Alain , Merillon Nathalie , Van Ryswick Cordelia , Quintin‐Colonna Françoise , Bruneval Patrick , Brasnu Daniel , Fridman Wolf H. , Tartour Eric 
Published: February 2010

AbstractHead and neck cancers are heavily infiltrated by immune cells, the significance of which is complex. The natural immune response against head and neck tumors, including anti‐human papillomavirus (HPV) T cells, and humoral responses has been clearly documented. However, during the course of tumor progression, co‐option of the immune system by tumor cells for their own advantage and increased resistance of tumor cells to immune attack also occur. Inflammation and immune subversion to support angiogenesis are key factors promoting tumor growth. Only a better understanding of this tumor–host interaction will permit a rational design of new immunotherapeutic approaches combining immunostimulation with drugs endowed with the ability to counteract immunoevasion mechanisms. © 2010 Wiley Periodicals, Inc. Head Neck, 2010
Future of the TNM classification and staging system in head and neck cancer
Authors: Takes Robert P. , Rinaldo Alessandra , Silver Carl E. , Piccirillo Jay F. , Haigentz Missak , Suárez Carlos , Van der Poorten Vincent , Hermans Robert , Rodrigo Juan Pablo , Devaney Kenneth O. , Ferlito Alfio 
Published: February 2010

AbstractStaging systems for cancer, including the most universally used TNM classification system, have been based almost exclusively on anatomic information. However, the question arises whether staging systems should be based on this information alone. Other parameters have been identified that should be considered for inclusion in classification systems like the TNM. This is all the more important, as a shift toward nonsurgical treatments for head and neck cancer has been made over the years. For these treatment modalities tumor/biologic characteristics next to anatomic information may be particularly important for treatment choice and outcome. The shortcomings of the current TNM classification system will be discussed, along with suggestions for improvement and expansion of the TNM system based on tumor, patient, and environment‐related factors. Further improvement of the TNM classification is expected to result in better treatment choices, outcome and prognostication of patients with head and neck cancer. © 2010 Wiley Periodicals, Inc. Head Neck, 2010
Sonographic diagnosis of a large and deep endometrioma of the uterine cervix
Authors: Coccia Maria Elisabetta , Rizzello Francesca , Castellacci Eleonora , Cammilli Fiamma 
Published: February 2010

AbstractWe present a rare case of endometriosis of the cervix. Transvaginal sonography showed a 35‐mm cyst in the cervix with diffuse, low‐level internal echoes. Transvaginal sonography‐guided aspiration with a 17‐gauge needle was performed, yielding a very thick chocolate‐colored fluid. Cytological examination of the fluid revealed the presence of endometrial cells. Symptoms resolved after aspiration and no recurrence has developed. © 2010 Wiley Periodicals, Inc. J Clin Ultrasound, 2010
Prenatal diagnosis of an intertwin membrane hematoma
Authors: Kacerovsky Marian , Tosner Jindrich 
Published: February 2010

AbstractWe report a case of a 26‐year‐old woman, gravida 2, para 1, with a dichorionic diamniotic twin pregnancy at 33 weeks of gestation with a 1‐day history of mild vaginal bleeding and irregular uterine activity. Ultrasonography showed 18 × 15 × 3‐cm‐sized complex hypoechoic mass located in the dividing intertwin membrane. Based on this finding, the diagnosis of an intertwin membrane hematoma was made. This unusual sonographic diagnosis was confirmed during the cesarean section. In the case of dichorionic twin pregnancy, partial placental abruption can lead to a subclinical intertwin membrane hematoma. © 2010 Wiley Periodicals, Inc. J Clin Ultrasound 38:397‐399, 2010
Cardiac MRI evaluation of nonischemic cardiomyopathies
Authors: François Christopher J. , Schiebler Mark L. , Reeder Scott B. 
Published: February 2010

AbstractThe purpose of this manuscript is to review the major MRI findings in patients with nonischemic cardiomyopathies. Cardiac MRI has become an integral part in the diagnosis and management of patients with nonischemic cardiomyopathies. Findings on cardiac MRI studies can help distinguish between different types of cardiomyopathies and can provide valuable diagnostic and prognostic information. J. Magn. Reson. Imaging 2010;31:518–530. © 2010 Wiley‐Liss, Inc.
Preinterventional quantitative magnetic resonance imaging predicts uterus and leiomyoma size reduction after uterine artery embolization
Authors: Sipola Petri , Ruuskanen Anu , Yawu Liu , Husso Minna , Vanninen Ritva , Hippeläinen Maritta , Manninen Hannu 
Published: February 2010

AbstractPurpose:To investigate the relationship between magnetic resonance imaging (MRI) measures and uterus and leiomyoma size reductions after uterine artery embolization (UAE).Materials and Methods:Fifty‐two women with leiomyomas underwent selective UAEs. Uterine and dominant leiomyoma sizes were measured with preinterventional MRI and a 6‐month follow‐up MRI. Four MRI measures of the dominant leiomyoma were recorded: T1 time; T2 time; leiomyoma‐to‐skeletal muscle T2 SI‐ratio; and percentage of contrast enhancement. To evaluate the predictive value of MRI measures we used Spearman rank correlation, area under the receiver operating characteristic (ROC) curve (Az), and values for diagnostic performance.Results:Uterus and dominant leiomyoma size reductions were highly variable. Leiomyoma size reductions of ≥75% were accurately predicted with leiomyoma‐to‐skeletal muscle T2 SI‐ratio (ROC curve Az = 0.930; 95% confidence interval [CI]: 0.853, 1.000). Leiomyoma size reductions ≥75% were predicted by leiomyoma‐to‐skeletal muscle T2 SI‐ratio ≥3.5 and T1‐time ≥750 msec with 100% and 86% sensitivities and 67% and 72% specificities, respectively. Uterus size reduction ≥50% were identified by dominant leiomyoma‐to‐skeletal muscle T2 SI‐ratio ≥2.5.Conclusion:Uterus and dominant leiomyoma size reductions after UAE were predicted with preoperative MRI measures of the dominant leiomyoma. J. Magn. Reson. Imaging 2010;31:617–624. © 2010 Wiley‐Liss, Inc.
Accelerating non‐contrast‐enhanced MR angiography with inflow inversion recovery imaging by skipped phase encoding and edge deghosting (SPEED)
Authors: Chang Zheng , Xiang Qing‐San , Shen Hao , Yin Fang‐Fang 
Published: February 2010

AbstractPurpose:To accelerate non‐contrast‐enhanced MR angiography (MRA) with inflow inversion recovery (IFIR) with a fast imaging method, Skipped Phase Encoding and Edge Deghosting (SPEED).Materials and Methods:IFIR imaging uses a preparatory inversion pulse to reduce signals from static tissue, while leaving inflow arterial blood unaffected, resulting in sparse arterial vasculature on modest tissue background. By taking advantage of vascular sparsity, SPEED can be simplified with a single‐layer model to achieve higher efficiency in both scan time reduction and image reconstruction. SPEED can also make use of information available in multiple coils for further acceleration. The techniques are demonstrated with a three‐dimensional renal non‐contrast‐enhanced IFIR MRA study.Results:Images are reconstructed by SPEED based on a single‐layer model to achieve an undersampling factor of up to 2.5 using one skipped phase encoding direction. By making use of information available in multiple coils, SPEED can achieve an undersampling factor of up to 8.3 with four receiver coils. The reconstructed images generally have comparable quality as that of the reference images reconstructed from full k‐space data.Conclusion:As demonstrated with a three‐dimensional renal IFIR scan, SPEED based on a single‐layer model is able to reduce scan time further and achieve higher computational efficiency than the original SPEED. J. Magn. Reson. Imaging 2010;31:757–765. © 2010 Wiley‐Liss, Inc.
Apparent diffusion coefficient and fractional anisotropy in the vertebral bone marrow
Authors: Ueda Yu , Miyati Tosiaki , Ohno Naoki , Motono Yuko , Hara Masaki , Shibamoto Yuta , Kasai Harumasa , Kawamitsu Hideaki , Matsubara Kosuke 
Published: February 2010

AbstractPurpose:To assess the state of cancellous tissue we analyzed the apparent diffusion coefficient (ADC) and fractional anisotropy (FA) in vertebral bone marrow.Materials and Methods:With 1.5 T magnetic resonance imaging (MRI), single‐shot diffusion echo planar imaging was used with b factors of 0 and 1000 s/mm2, diffusion‐sensitizing gradient in six directions, sensitivity encoding technique, effective TE of 74 msec, and TR of 1800 msec. ADC and FA were determined in the lumbar vertebral body of 11 normal subjects (age 31 632–635 years), and then compared with the bone mineral density (BMD) obtained with dual‐energy x‐ray absorptiometry (DXA). Moreover, fat fraction (FF) of the bone marrow was measured with spectral presaturation with inversion recovery (SPIR) in the same subject.Results:A strong negative correlation was found between ADC and BMD for low or moderate FF in vertebral bone marrow. Moreover, a significant positive correlation was noted between ADC and FF in this region. There was a positive correlation between FA and BMD, and no correlation between FA and FF in the vertebral bone marrow.Conclusion:Diffusion analyses with ADC and FA make it possible to obtain more detailed information on the structure of cancellous tissue and bone metabolism. J. Magn. Reson. Imaging 2010;31:632–635. © 2010 Wiley‐Liss, Inc.
Detection of hepatic hypovascular metastases: 3D gradient echo MRI using a hepatobiliary contrast agent
Authors: Choi Jin‐Young , Choi Jin‐Sub , Kim Myeong‐Jin , Lim Joon Seok , Park Mi Suk , Kim Joo Hee , Chung Yong Eun 
Published: February 2010

AbstractPurpose:To assess the diagnostic performance of gadobenate dimeglumine‐enhanced 3D gradient echo (3D‐GRE) magnetic resonance imaging (MRI) for the detection of hepatic hypovascular metastases.Materials and Methods:We retrospectively analyzed the initial radiologic reports of MRI of 41 patients with suspected hepatic metastases. Seventy‐nine metastatic lesions were confirmed by histopathology or intraoperative ultrasound (IOUS). The sensitivity and positive predictive values for the diagnosis of hepatic metastasis were determined among each MRI set (hepatobiliary phase, precontrast images, dynamic imaging). The diagnostic performance of dynamic image set and combined dynamic and hepatobiliary image set was also evaluated by two radiologists using alternative free response receiver operating characteristic (ROC) analysis.Results:The overall detection rate and positive predictive value of MR were 96.2% (76/79) and 96.2% (76/79), respectively. Images obtained with hepatobiliary phase 3D‐GRE showed a significantly better detection rate compared to those with precontrast sequences or dynamic imaging (P = 0.008 and 0.016, respectively). Regarding lesions 1 cm or smaller, the detection rate was 90.3% (28/31). Each reader showed a higher Az value of the combined hepatobiliary image set than those of the dynamic image set.Conclusion:3D‐GRE MRI using a hepatobiliary contrast agent is an accurate tool in the detection of hepatic hypovascular metastases and improves detection rate compared with precontrast and dynamic imaging. J. Magn. Reson. Imaging 2010;31:571–578. © 2010 Wiley‐Liss, Inc.
Diagnosis of cirrhosis with intravoxel incoherent motion diffusion MRI and dynamic contrast‐enhanced MRI alone and in combination: Preliminary experience
Authors: Patel Jignesh , Sigmund Eric E. , Rusinek Henry , Oei Marcel , Babb James S. , Taouli Bachir 
Published: February 2010

AbstractPurpose:To report our preliminary experience with the use of intravoxel incoherent motion (IVIM) diffusion‐weighted magnetic resonance imaging (DW‐MRI) and dynamic contrast‐enhanced (DCE)‐MRI alone and in combination for the diagnosis of liver cirrhosis.Materials and Methods:Thirty subjects (16 with noncirrhotic liver, 14 with cirrhosis) were prospectively assessed with IVIM DW‐MRI (n = 27) and DCE‐MRI (n = 20). IVIM parameters included perfusion fraction (PF), pseudodiffusion coefficient (D*), true diffusion coefficient (D), and apparent diffusion coefficient (ADC). Model‐free DCE‐MR parameters included time to peak (TTP), upslope, and initial area under the curve at 60 seconds (IAUC60). A dual input single compartmental perfusion model yielded arterial flow (Fa), portal venous flow (Fp), arterial fraction (ART), mean transit time (MTT), and distribution volume (DV). The diagnostic performances for diagnosis of cirrhosis were evaluated for each modality alone and in combination using logistic regression and receiver operating characteristic analyses. IVIM and DCE‐MR parameters were compared using a generalized estimating equations model.Results:PF, D*, D, and ADC values were significantly lower in cirrhosis (P = 0.0056–0.0377), whereas TTP, DV, and MTT were significantly increased in cirrhosis (P = 0.0006–0.0154). There was no correlation between IVIM‐ and DCE‐MRI parameters. The highest Az (areas under the curves) values were observed for ADC (0.808) and TTP‐DV (0.952 for each). The combination of ADC with DV and TTP provided 84.6% sensitivity and 100% specificity for diagnosis of cirrhosis.Conclusion:The combination of DW‐MRI and DCE‐MRI provides an accurate diagnosis of cirrhosis. J. Magn. Reson. Imaging 2010;31:589–600. © 2010 Wiley‐Liss, Inc.
Clinical evaluation of aortic coarctation with 4D flow MR imaging
Authors: Hope Michael D. , Meadows Alison K. , Hope Thomas A. , Ordovas Karen G. , Saloner David , Reddy Gautham P. , Alley Marcus T. , Higgins Charles B. 
Published: February 2010

AbstractPurpose:To show that 4D Flow is a clinically viable tool for evaluation of collateral blood flow and demonstration of distorted blood flow patterns in patients with treated and untreated aortic coarctation.Materials and Methods:Time‐resolved, 3D phase contrast magnetic resonance imaging (MRI) (4D Flow) was used to assess blood flow in the thoracic aorta of 34 individuals: 26 patients with coarctation (22 after surgery or stent placement) and eight healthy volunteers.Results:Direct comparison of blood flow calculated with 2D and 4D phase contrast data at standard levels for analysis in coarctation patients showed good correlation and agreement (correlation coefficient r = 0.99, limits of agreement = −20% to 20% for collateral blood flow calculations). Abnormal blood flow patterns were demonstrated at peak systole with 4D Flow visualization techniques in the descending thoracic aorta of patients but not volunteers. Marked helical flow was seen in 9 of 13 patients with angulated aortic arch geometries after coarctation repair. Vortical flow was seen in regions of poststenotic dilation.Conclusion:4D Flow is a fast and reliable means of evaluating collateral blood flow in patients with aortic coarctation in order to establish hemodynamic significance. It also can detect distorted blood flow patterns in the descending aorta after coarctation repair. J. Magn. Reson. Imaging 2010;31:711–718. © 2010 Wiley‐Liss, Inc.
MRI and S‐MRCP findings in patients with suspected chronic pancreatitis: Correlation with endoscopic pancreatic function testing (ePFT)
Authors: Balci N. Cem , Smith Adam , Momtahen Amir Javad , Alkaade Samer , Fattahi Rana , Tariq Syed , Burton Frank 
Published: February 2010

AbstractPurpose:To review magnetic resonance imaging (MRI) and secretin stimulated magnetic resonance cholangiopancreatography (S‐MRCP) findings of patients with suspected chronic pancreatitis and compare them with endoscopic pancreatic function testing (ePFT).Materials and Methods:MRI and S‐MRCP findings of 36 patients with clinically suspected chronic pancreatitis were reviewed. Baseline ductal changes, duodenal filling grades, and pancreatic duct caliber change (PDC) on S‐MRCP, mean values of pancreatic anteroposterior (AP) diameter, signal intensity ratio (SIR) between pancreas and the spleen on T1‐weighted fat saturated images, and arterial to venous (A/V) enhancement ratios were compared between groups of normal and abnormal pancreatic exocrine function determined by ePFT.Results:All patients (n = 24) with normal ePFT (HCO3 >80 mEq/L) had grade 3 normal duodenal filling. Patients with abnormal ePFT (HCO3 <80 mEq/L) (n = 12) had grade 1 (n = 1) and grade 2 (n = 11) diminished duodenal filling (P < 0.0001). PDC was 1.51 in the normal ePFT group versus 1.27 in the abnormal ePFT group (P = 0.01). No significant differences were found in terms of mean pancreatic AP diameter (21.8 vs. 19.8 cm), SIR (1.59 vs. 1.44), and A/V (1.08 vs. 1.01) between groups of normal/abnormal pancreatic exocrine function.Conclusion:Despite discrepancies between pancreatic exocrine function and the findings on standard MRI/MRCP, the S‐MRCP findings are comparable to ePFT in the evaluation of chronic pancreatitis. J. Magn. Reson. Imaging 2010;31:601–606. © 2010 Wiley‐Liss, Inc.
Evaluation of gadobutrol, a macrocyclic, nonionic gadolinium chelate in a brain glioma model: Comparison with gadoterate meglumine and gadopentetate dimeglumine at 1.5 T, combined with an assessment of field strength dependence, specifically 1.5 versus 3 T
Authors: Attenberger Ulrike I. , Runge Val M. , Morelli John N. , Williams Jonathan , Jackson Carney B. , Michaely Henrik J. 
Published: February 2010

AbstractPurpose:To evaluate in a rat brain glioma model intraindividual tumor enhancement at 1.5 T using gadobutrol (Gadovist), a nonionic, macrocyclic chelate currently in clinical trials in the United States, in comparison with both an ionic macrocyclic chelate, gadoterate meglumine (Dotarem), and an ionic linear chelate, gadopentetate dimeglumine (Magnevist), and to compare the degree of tumor enhancement with gadobutrol at 1.5 and 3 T.Materials and Methods:A total of 24 rats, divided into three groups with n = 8 animals per group, were evaluated. Animals in group 1 received injections of gadobutrol and gadopentetate dimeglumine, whereas those in group 2 received gadobutrol and gadoterate meglumine. Injections were performed in random order and separated by 24 hours. Magnetic resonance imaging (MRI) examinations were performed immediately following each contrast injection with a 1.5 T MR system. Animals in group 3 received gadobutrol injections using the same protocol but with scans performed at 1.5 and 3 T. In all examinations, T1‐weighted images were acquired precontrast, 1 minute postcontrast, and at 4 consecutive 2‐minute intervals thereafter. A contrast dose of 0.1 mmol/kg was used in all instances.Results:In groups 1 and 2, tumor signal‐to‐noise ratio (SNR) and contrast‐to‐noise ratio (CNR) were higher for gadobutrol compared to both other agents at each timepoint postcontrast injection. The improvement in tumor CNR with gadobutrol, depending on time, was between 12% and 40% versus gadopentetate dimeglumine, with the difference achieving statistical significance at 7 minutes. The improvement in tumor CNR with gadobutrol, depending on time, was between 15% and 27% versus gadoterate meglumine, with the difference statistically significant at 5 and 9 minutes. In group 3 the improvement in tumor SNR and CNR seen with the increase in field strength from 1.5 to 3 T for gadobutrol was statistically significant at all acquired timepoints (P < 0.002). CNR mean values ranged from 10.4 ± 2.9 to 24.6 ± 5.0 at 1.5 T and from 20.5 ± 5.9 to 47.8 ± 15.7 at 3 T depending on the timepoint postcontrast.Conclusion:Consistently greater tumor enhancement was noted at all measured timepoints following contrast injection with gadobutrol compared to both gadopentetate dimeglumine and gadoterate meglumine at 1.5 T. A substantial further improvement in tumor enhancement was noted using gadobutrol at 3 T. J. Magn. Reson. Imaging 2010;31:549–555. © 2010 Wiley‐Liss, Inc.
Multiparametric magnetic resonance imaging for the differentiation between benign and malignant salivary gland tumors
Authors: Eida Sato , Sumi Misa , Nakamura Takashi 
Published: February 2010

AbstractPurpose:To evaluate the stepwise approach in differentiating between benign and malignant salivary gland tumors using time‐intensity curves (TICs) and apparent diffusion coefficients (ADCs).Materials and Methods:TICs and ADCs were analyzed on the tumor‐by‐tumor (overall) and pixel‐by‐pixel (TIC and ADC maps) bases in patients with benign (n = 52) or malignant (n = 18) salivary gland tumor. TICs were categorized into Types 1 (<20% increment ratio), 2 (≥20% increment ratio and >120 sec peak time), 3 (≥20% increment ratio, ≤120 sec peak time, and <30% washout ratio), or 4 (≥20% increment ratio, ≤120 sec peak time, and ≥30% washout ratio). ADCs were classified as extremely low (<0.6 × 10−3 mm2/sec), low (<1.2), intermediate (<1.8), or high (≥1.8).Results:Malignant tumors had small (<30%) areas with Type 1 TIC with one of the following magnetic resonance imaging (MRI) characteristics: Type 3 overall TIC patterns, Type 4 overall TIC patterns and extremely low (<0.60 × 10−3 mm2/sec) overall ADCs, or Type 2 overall TIC patterns and large (>40%) areas with low or extremely low ADCs.Conclusion:We propose a stepwise approach by using multiparametric MRI techniques as an effective tool for differentiating between benign and malignant salivary gland tumors J. Magn. Reson. Imaging 2010;31:673–679. © 2010 Wiley‐Liss, Inc.