bluuebunny/crossref_metadata_2025_split huggingface dataset:
Masseteric venous malformations: Diagnosis, treatment, and outcomes
Authors: Rosbe Kristina W. , Hess Christopher P. , Dowd Christopher F. , Frieden Ilona J. 
Published: October 2010

OBJECTIVETo describe a typical presentation of venous malformation within the masseter muscle, including physical findings and imaging, and to present the University of California, San Francisco's (UCSF) Vascular Anomalies and Birthmark Center's (VABC) experience with sclerotherapy for these lesions. STUDY DESIGN: Case series with chart review.SETTINGTertiary care medical center.SUBJECTS AND METHODSRetrospective chart review of all patients presenting to the UCSF VABC over a 10‐year period.RESULTSTwelve patients with isolated venous malformations of the masseter muscle were identified. All of these patients presented with pain and facial asymmetry that was more pronounced with jaw‐clenching. All underwent magnetic resonance imaging demonstrating a T2 hyperintense homogenous mass contained within the masseter muscle. Eleven of 12 had evidence on imaging of phleboliths within the mass; 10 patients underwent sclerotherapy. All treated patients had initial improvement in symptoms and/or appearance. Seven of 10 have had sustained improvement at a mean follow‐up of 28 months.CONCLUSIONMasseteric venous malformations have a typical clinical presentation and imaging characteristics that should allow clinicians to distinguish them from other abnormalities presenting in this area. Percutaneous sclerotherapy should be considered as a treatment option for these patients and can result in excellent outcomes.
Characterization of the Expression of Ang1, Ang2, and Tie2 in the Corpus Cavernosum of the Rat during Aging
Authors: Cordeiro Ana Lúcia , Figueiredo António , Tomada Inês , de Almeida Henrique , Neves Delminda 
Published: October 2010

AbstractAging is the single most significant risk factor for erectile dysfunction (ED), leading to structural modification of cavernous tissue and altering expression of vascular growth factors. The angiopoietin/Tie2 system has been recently considered as a potential target for therapy of vascular disorders, including ED. Hence, the aim of this study was to analyze expression of angiopoietin1 (Ang1), angiopoietin2 (Ang2), and their receptor Tie2 in corpus cavernosum (CC) of rat during aging (6, 12, 18, and 24 months). The expression of Ang1, Ang2, and Tie2 was studied by immunohistochemistry and immunofluorescence, followed by semiquantification after Western blotting. Both Ang1 and Ang2 were localized mainly in perivascular smooth muscle and endothelial cells, while Tie2 was strictly detected at the vascular endothelium. A significant decrease in Ang2's expression was observed at 12 months when compared with 6-month-old rats, a tendency that reverses in older animals. No significant differences were demonstrated for Ang1 or Tie2, which is consistent with their constitutive expression in CC. The ratios Ang1/Tie2 and Ang2/Tie2 were also calculated and both decrease during aging, while no marked variation was observed for Ang1/Ang2. Our results suggest that the angiopoietin/Tie2 system participate in the vascular maintenance and remodeling of the CC during aging.
Depoliticization and Regulation of Sovereign Wealth Funds: A Chinese Perspective
Authors: LI Hong 
Published: October 2010

AbstractThe China Investment Corporation (CIC) has often been perceived as a threat by Western economies. Such fears, however, are unfounded as the severe losses incurred by CIC during the recent economic crisis reveals that the fund, just like other investment entities, is vulnerable to market conditions. Moreover, given their relative lack of expertise in international investment, the regulation and development of “young and inexperienced” sovereign wealth funds (SWFs) within their home state is more pertinent than the defensive regulation structured by the host states in which SWFs invest. Positive financial returns should always be the fundamental goal of SWFs, rather than non-commercial considerations. This article proposes a three-step approach to regulating SWFs from a Chinese perspective: (1) home states should distinguish between their roles as shareholders and managers of state-owned capital-exporting institutions, and can use the Santiago Principles for that purpose; (2) host countries should not discriminate against SWFs but treat them as private institutional investors; and (3) there should be a clarification of the international investment regime regarding state investment. If these three steps are taken, SWFs would be depoliticized, and biased regulatory agencies and regulations would be a thing of the past. Under a broad regime, concerns between home and host states could then be addressed at bilateral or multilateral forums.
Experimental Aspergillus fumigatus Infection in Quails and Results of Treatment with Itraconazole
Authors: Gümüşsoy K. S. , Uyanik F. , Atasever A. , Çam Y. 
Published: October 2010

SummaryThis study was performed to investigate (i) the clinical, histopathological and biochemical changes in quails (Coturnix coturnix japonica) with experimentally induced aspergillosis; and (ii) the efficiency of itraconazole treatment on these infected birds. A total of 180 21‐day‐old male quails was randomly divided into three groups (control, infected untreated and infected treated), each containing 60. The experimental infection was set by intratracheal inoculation of 0.2 ml inoculum of Aspergillus fumigatus (CBS 113.26 strain) consisting of approximately 2.7 × 106 spores/ml. Two days after the inoculation, general clinical signs of aspergillosis in the respiratory tract were observed. In the histopathological examination, caseous foci were found in lungs, trachea and on airsacs. All quails died in the infected untreated group. Aspergillus fumigatus was isolated from the various organs of all dead quails. There was no significant change in serum aspartate aminotransferase (AST) and γ‐glutamyltransferase (GGT) activities in infected untreated birds compared with controls. However, alanine aminotransferase (ALT) activity, albumin and calcium levels, and albumin/globulin (A/G) ratio were lower while phosphorus and globulin levels were higher in the infected untreated group than in controls. Each quail in the infected treated group was given 10 mg/kg/day itraconazole via drinking water for 7 days immediately after the first clinical findings. Although all quails died in the infected untreated group, 41 quails survived in the itraconazole treatment group. Biochemical values also returned approximately to the control levels after the treatment. The conclusion was drawn that aspergillosis in the quails might cause economical losses because of high mortality. Oral itraconazole treatment of aspergillosis might lower the mortality rate in quails.
Cut‐induced VOC emissions from agricultural grasslands
Authors: Davison B. , Brunner A. , Ammann C. , Spirig C. , Jocher M. , Neftel A. 
Published: October 2010

AbstractThe introduction of proton transfer reaction mass spectrometry (PTR‐MS) for fast response measurements of volatile organic compounds (VOC) has enabled the use of eddy covariance methods to investigate VOC fluxes on the ecosystem scale. In this study PTR‐MS flux measurements of VOC were performed over agricultural grassland during and after a cut event. Selected masses detected by the PTR‐MS showed fluxes of methanol, acetaldehyde, and acetone. They were highest directly after cutting and during the hay drying phase. Simultaneously, significant fluxes of protonated ion masses 73, 81, and 83 were observed. Due to the limited identification of compounds with the PTR‐MS technique, GC‐MS and GC‐FID‐PTR‐MS techniques were additionally applied. In this way, ion mass 73 could be identified as 2‐butanone, mass 81 mainly as (Z)‐3‐hexenal, and mass 83 mainly as the sum of (Z)‐3‐hexenol and hexenyl acetates. Hexenal, hexenols, and the hexenyl acetates are mostly related to plant wounding during cutting. It was found that legume plants and forbs emit a higher number of different VOC species than graminoids.
Bloodstream Infections Caused by Metallo-β-Lactamase/Klebsiella pneumoniae Carbapenemase–Producing K. pneumoniae among Intensive Care Unit Patients in Greece: Risk Factors for Infection and Impact of Type of Resistance on Outcomes
Authors: Mouloudi Eleni , Protonotariou Euthymia , Zagorianou Alexia , Iosifidis Elias , Karapanagiotou Areti , Giasnetsova Tatiana , Tsioka Agoritsa , Roilides Emmanuel , Sofianou Danai , Gritsi-Gerogianni Nikoleta 
Published: October 2010

Objective.To determine risk factors for bloodstream infections (BSIs) caused by Klebsiella pneumoniae producing metallo-β-lactamases (MBLs) or K. pneumoniae carbapenemases (KPCs), as well as risk factors for mortality associated with carbapenem-resistant K. pneumoniae, among intensive care unit (ICU) patients.Methods.Two case-control studies were conducted in a patient cohort with K. pneumoniae BSIs in an 8-bed ICU in a Greek hospital from January 1, 2007, through December 31, 2008. In study 1, patients with K. pneumoniae BSIs were allocated among 3 groups according to isolate susceptibility profile: (1) carbapenem-susceptible insolates (control group), (2) MBL-producing isolates, or (3) KPC-producing isolates. The MBL and KPC groups were compared with the control group to identify risk factors for development of K. pneumoniae BSI. In study 2, patients with K. pneumoniae BSIs who died were compared with survivors to identify risk factors for mortality.Results.Fifty-nine patients had K. pneumoniae BSIs (22 with carbapenem-susceptible isolates, 18 with MBL-producing isolates, and 19 with KPC-producing isolates). All KPC-producing isolates carried the blaKPC-2 gene, and 17 of 18 MBL-producing isolates carried blaVIM-1 Acute Physiology and Chronic Health Evaluation II score (odds ratio, 1.13 [95% confidence interval, 1.03–1.25]; P = .02) was independently associated with KPC-producing K. pneumoniae BSIs. Nine (41%) of 22 control patients, 8 (44%) of 18 MBL group patients, and 13 (68%) of 19 KPC group patients died in the ICU. Nine (41%) of 22 control patients, 10 (56%) of 18 MBL group patients, and 15 (79%) of 19 KPC group patients died in the hospital. Isolation of KPC-producing K. pneumoniae was an independent predictor of ICU death (P = .04) and in-hospital death (P = .03) but not infection-attributable death.Conclusions.BSIs due to KPC-producing K. pneumoniae resulted in significantly increased mortality. The accurate and rapid detection of these pathogens is necessary for therapeutic considerations and for the implementation of infection control measures to contain them.
Interoperability between phenotype and anatomy ontologies
Authors: Hoehndorf Robert , Oellrich Anika , Rebholz-Schuhmann Dietrich 
Published: October 2010

Abstract
Motivation: Phenotypic information is important for the analysis of the molecular mechanisms underlying disease. A formal ontological representation of phenotypic information can help to identify, interpret and infer phenotypic traits based on experimental findings. The methods that are currently used to represent data and information about phenotypes fail to make the semantics of the phenotypic trait explicit and do not interoperate with ontologies of anatomy and other domains. Therefore, valuable resources for the analysis of phenotype studies remain unconnected and inaccessible to automated analysis and reasoning.
Results: We provide a framework to formalize phenotypic descriptions and make their semantics explicit. Based on this formalization, we provide the means to integrate phenotypic descriptions with ontologies of other domains, in particular anatomy and physiology. We demonstrate how our framework leads to the capability to represent disease phenotypes, perform powerful queries that were not possible before and infer additional knowledge.
Availability: http://bioonto.de/pmwiki.php/Main/PheneOntology
Contact: rh497@cam.ac.uk
Generalized random set framework for functional enrichment analysis using primary genomics datasets
Authors: Freudenberg Johannes M. , Sivaganesan Siva , Phatak Mukta , Shinde Kaustubh , Medvedovic Mario 
Published: October 2010

Abstract
Motivation: Functional enrichment analysis using primary genomics datasets is an emerging approach to complement established methods for functional enrichment based on predefined lists of functionally related genes. Currently used methods depend on creating lists of ‘significant’ and ‘non-significant’ genes based on ad hoc significance cutoffs. This can lead to loss of statistical power and can introduce biases affecting the interpretation of experimental results.
Results: We developed and validated a new statistical framework, generalized random set (GRS) analysis, for comparing the genomic signatures in two datasets without the need for gene categorization. In our tests, GRS produced correct measures of statistical significance, and it showed dramatic improvement in the statistical power over other methods currently used in this setting. We also developed a procedure for identifying genes driving the concordance of the genomics profiles and demonstrated a dramatic improvement in functional coherence of genes identified in such analysis.
Availability: GRS can be downloaded as part of the R package CLEAN from http://ClusterAnalysis.org/. An online implementation is available at http://GenomicsPortals.org/.
Contact: mario.medvedovic@uc.edu
Supplementary information: Supplementary data are available at Bioinformatics online.
The GMOD Drupal Bioinformatic Server Framework
Authors: Papanicolaou Alexie , Heckel David G. 
Published: October 2010

Abstract
Motivation: Next-generation sequencing technologies have led to the widespread use of -omic applications. As a result, there is now a pronounced bioinformatic bottleneck. The general model organism database (GMOD) tool kit (http://gmod.org) has produced a number of resources aimed at addressing this issue. It lacks, however, a robust online solution that can deploy heterogeneous data and software within a Web content management system (CMS).
Results: We present a bioinformatic framework for the Drupal CMS. It consists of three modules. First, GMOD-DBSF is an application programming interface module for the Drupal CMS that simplifies the programming of bioinformatic Drupal modules. Second, the Drupal Bioinformatic Software Bench (biosoftware_bench) allows for a rapid and secure deployment of bioinformatic software. An innovative graphical user interface (GUI) guides both use and administration of the software, including the secure provision of pre-publication datasets. Third, we present genes4all_experiment, which exemplifies how our work supports the wider research community.
Conclusion: Given the infrastructure presented here, the Drupal CMS may become a powerful new tool set for bioinformaticians. The GMOD-DBSF base module is an expandable community resource that decreases development time of Drupal modules for bioinformatics. The biosoftware_bench module can already enhance biologists' ability to mine their own data. The genes4all_experiment module has already been responsible for archiving of more than 150 studies of RNAi from Lepidoptera, which were previously unpublished.
Availability and implementation: Implemented in PHP and Perl. Freely available under the GNU Public License 2 or later from http://gmod-dbsf.googlecode.com
Contact: alexie@butterflybase.org
GAMES identifies and annotates mutations in next-generation sequencing projects
Authors: Sana Maria Elena , Iascone Maria , Marchetti Daniela , Palatini Jeff , Galasso Marco , Volinia Stefano 
Published: October 2010

Abstract
Motivation: Next-generation sequencing (NGS) methods have the potential for changing the landscape of biomedical science, but at the same time pose several problems in analysis and interpretation. Currently, there are many commercial and public software packages that analyze NGS data. However, the limitations of these applications include output which is insufficiently annotated and of difficult functional comprehension to end users.
Results: We developed GAMES (Genomic Analysis of Mutations Extracted by Sequencing), a pipeline aiming to serve as an efficient middleman between data deluge and investigators. GAMES attains multiple levels of filtering and annotation, such as aligning the reads to a reference genome, performing quality control and mutational analysis, integrating results with genome annotations and sorting each mismatch/deletion according to a range of parameters. Variations are matched to known polymorphisms. The prediction of functional mutations is achieved by using different approaches. Overall GAMES enables an effective complexity reduction in large-scale DNA-sequencing projects.
Availability: GAMES is available free of charge to academic users and may be obtained from http://aqua.unife.it/GAMES.
Contact: stefano.volinia@unife.it
Controls on pathogen species richness in plants’ introduced and native ranges: roles of residence time, range size and host traits
Authors: Mitchell Charles E. , Blumenthal Dana , Jarošík Vojtěch , Puckett Emily E. , Pyšek Petr 
Published: October 2010

Ecology Letters(2010) 13: 1525–1535AbstractIntroduced species escape many pathogens and other enemies, raising three questions. How quickly do introduced hosts accumulate pathogen species? What factors control pathogen species richness? Are these factors the same in the hosts’ native and introduced ranges? We analysed fungal and viral pathogen species richness on 124 plant species in both their native European range and introduced North American range. Hosts introduced 400 years ago supported six times more pathogens than those introduced 40 years ago. In hosts’ native range, pathogen richness was greater on hosts occurring in more habitat types, with a history of agricultural use and adapted to greater resource supplies. In hosts’ introduced range, pathogen richness was correlated with host geographic range size, agricultural use and time since introduction, but not any measured biological traits. Introduced species have accumulated pathogens at rates that are slow relative to most ecological processes, and contingent on geographic and historic circumstance.
Landlord Attitudes and Behaviors Regarding Smoke‐Free Policies: Implications for Voluntary Policy Change
Authors: Cramer Mary E. , Roberts Sara , Stevens Elizabeth 
Published: October 2010

ABSTRACT
Objective: Objective: The study purpose was to describe multiunit landlord attitudes and behaviors toward smoke‐free policies.Design and Sample: This was a descriptive, cross‐sectional survey of multiunit landlords in Douglas County (N=392). Measures: A 25‐item survey was developed and pilot tested. It was administered by telephone (n=143) and mail (n=249) to multiunit landlords.Results: Combined response rate was 30.1% (81/143 telephone, 37/249 mail) representing 24,080 units on 974 properties with 34,399 tenants. Most respondents (73.7%) allowed smoking. Reasons for not implementing smoke‐free policies were potential enforcement problems (57.0%), tenant objections (43.0%), loss of market share (39.5%). Respondents without smoke‐free policies expected vacancy (53.6%) and turnover (50.0%) rates to increase, which was significantly different (p <.0001) than respondents with smoke‐free policies where only 10.7% reported increased vacancy and only 3.7% reported increased turnover.Conclusions: Expected adverse impacts of smoke‐free policies do not reflect real experiences of smoke‐free policy implementation. Public health advocates can use these study findings to develop community‐based education and social marketing messages directed at voluntary smoke‐free policy changes. Respondents without smoke‐free policies expressed interest at the end of the survey in learning how to implement smoke‐free policies indicating a readiness for change.
Peri‐implant reconstruction using autologous periosteum‐derived cells and guided bone regeneration
Authors: Ribeiro Fernanda Vieira , Suaid Fabricia Ferreira , Ruiz Karina Gonzales Silverio , Rodrigues Thaisângela Lopes , Carvalho Marcelo Diniz , Nociti Francisco Humberto , Sallum Enilson Antonio , Casati Márcio Zaffalon 
Published: October 2010

Ribeiro FV, Suaid FF, Ruiz KGS, Rodrigues TL, Carvalho MD, Nociti FH, Sallum EA, Casati MZ. Peri‐implant reconstruction using autologous periosteum‐derived cells and guided bone regeneration. J Clin Periodontol 2010; doi: 10.1111/j.1600‐051X.2010.01635.x.AbstractAim: This investigation evaluated the bone healing in peri‐implant defects treated with periosteum‐derived cells (PCs) and guided bone regeneration (GBR).Material and Methods: PCs were harvested from six beagle dogs and characterized in vitro with regard to their osteogenic properties. The animals were subjected to teeth extraction in the mandible, and after 3 months of healing, implant sites were drilled, bone dehiscences were created and implants were placed. Dehiscences were randomly assigned to: PCs+GBR, GBR, PCs and non‐treated defects. After 3 months, the implants/adjacent tissues were processed. Bone‐to‐implant contact (BIC) bone fill (BF) within implant threads, and bone area (BA) in a zone lateral to the implant were obtained.Results: In vitro analyses confirmed the osteogenic potential of PCs. Histometrically, no statistically significant differences were observed among the PCs+GBR, GBR and PCs groups for both BF and BIC (p>0.05), whereas these groups showed statistically higher values, as compared with the non‐treated group (p<0.05). With respect to BA, the PCs+GBR and GBR groups presented significantly higher means, as compared with the PCs and non‐treated groups (p<0.05).Conclusion: Although successful outcomes have been promoted by using the combined approach, PCs in conjunction with membranes did not provide additional benefit during peri‐implant bone regeneration, when compared with the therapeutic approaches used alone.
Cytotoxicity of calcium enriched mixture cement compared with mineral trioxide aggregate and intermediate restorative material
Authors: Mozayeni Mohammad A. , Milani Amin S. , Marvasti Laleh A. , Asgary Saeed 
Published: October 2010

AbstractCalcium enriched mixture (CEM) cement has been recently invented by the last author. It is composed of calcium oxide, calcium phosphate, calcium silicate and calcium sulphate; however, it has a different chemical composition to mineral trioxide aggregate (MTA). The purpose of this ex vivo study was to investigate the cytotoxicity of CEM cement, and compare it with intermediate restorative material (IRM) and MTA. The materials were tested in fresh and set states on L929 fibroblasts to assess their cytotoxicity. The cell viability responses were evaluated with methyl‐tetrazolium bromide assay and Elisa reader at 1, 24 and 168 h (7 days). The tested materials were eluted with L929 culture medium according to international standard organisation 109935 standard. Distilled water and culture medium served as positive and negative controls, respectively. Differences in cytotoxicity were evaluated by one‐way anova and t‐tests. The cytotoxicity of the materials was statistically different at the three time intervals (P < 0.01). The lowest cytotoxic values recorded were expressed by MTA subgroups followed by CEM cement; IRM subgroups were the most cytotoxic root‐end/dental material (P < 0.001). CEM cement and MTA are reasonable alternatives to IRM because of lower cytotoxicity. CEM cement also has good biocompatibility as well as lower estimated cost to MTA and seems to be a promising dental material.