bluuebunny/crossref_metadata_2025_split huggingface dataset:
Uterine necrosis following uterine artery embolization as treatment for postpartum hemorrhage: A case report and literature review
Authors: Yin Huifen , Liu Haiyan , Hu Rong 
Published: May 2024

AbstractUterine necrosis is a rare complication of uterine artery embolization for postpartum hemorrhage and most patients end up having a hysterectomy. Here we report a case in which the patient experienced a recurrent fever 28 days after uterine artery embolization as treatment for postpartum hemorrhage and had no response to antibiotics. Magnetic resonance imaging of the pelvis revealed a mass which was approximately 12‐cm in size with air bubbles in the uterus, suggesting necrosis with infection. Transvaginal clamping of the uterine mass was performed and necrotic tissue removed under laparoscopic monitoring, which successfully spared the necessity for a hysterectomy. The patient's subsequent progress was favorable. In the present study we review the high‐risk factors of uterine necrosis following uterine artery embolization and summarize the key points of early diagnosis. In addition, we propose a strategy to successfully spare the necessity for a hysterectomy without the spread of infection or uterine perforation.
Initial experience of enfortumab vedotin in a patient with metastatic urothelial carcinoma on hemodialysis: Two case reports
Authors: Mori Shintaro , Matsuo Tomohiro , Honda Hiroyuki , Araki Kyohei , Mitsunari Kensuke , Ohba Kojiro , Mochizuki Yasushi , Imamura Ryoichi 
Published: May 2024

IntroductionFew studies have reported on administering enfortumab vedotin to patients with metastatic urothelial carcinoma and end‐stage renal disease requiring hemodialysis.Case presentationCase 1: An 85‐year‐old man underwent hemodialysis for progressive renal failure 4 months after right laparoscopic radical nephroureterectomy. Case 2: A 73‐year‐old man underwent hemodialysis after two laparoscopic radical nephroureterectomies for recurrent urothelial carcinoma. In both cases, enfortumab vedotin was administered due to postoperative recurrence and progression despite platinum‐based chemotherapy and pembrolizumab. Partial response and disease progression were observed in cases 1 and 2, respectively. Adverse events included a mild skin rash in both patients and neutropenia in Case 1, both of which resolved with symptomatic treatment.ConclusionThe efficacy and safety of enfortumab vedotin in patients with metastatic urothelial carcinoma, and end‐stage renal disease undergoing hemodialysis, were confirmed.
NSUN6 mediates 5‐methylcytosine modification of METTL3 and promotes colon adenocarcinoma progression
Authors: Cui Yuanbo , Lv Pengju , Zhang Chunyan 
Published: May 2024

AbstractColon adenocarcinoma (COAD) is a common and fatal malignant tumor of digestive system with complex etiology. 5‐Methylcytosine (m5C) modification of RNA by the NSUN gene family (NSUN1‐NSUN7) and DNMT2 reshape cell biology and regulate tumor development. However, the expression profile, prognostic significance and function of these m5C modifiers in COAD remain largely unclear. By mining multiple integrated tumor databases, we found that NSUN1, NSUN2, NSUN5, and NSUN6 were overexpressed in COAD tumor samples relative to normal samples. Clinically, high expression of NSUN6 was significantly associated with shorter survival (including both disease‐free survival and overall survival) in COAD patients. NSUN6 was further confirmed to be upregulated at both tissue and cellular levels of COAD, suggesting that NSUN6 plays a critical role in disease progression. Through comprehensive gene enrichment analysis and cell‐based functional validation, it was revealed that NSUN6 promoted the cell cycle progression and cell proliferation of COAD. Mechanistically, NSUN6 upregulates the expression of oncogenic METTL3 and catalyzes its m5C modification in COAD cells. Overexpression of METTL3 significantly relieved the cell cycle inhibition of COAD caused by NSUN6 deficiency. Furthermore, NSUN6 was negatively associated with the abundance of infiltrating immune cells in COAD tumors, such as activated B cells, natural killer cells, effector memory CD8 T cells, and regulatory T cells. Importantly, pan‐cancer analysis further uncovered that NSUN6 was dysregulated and heterogeneous in various tumors. Thus our findings extend the role of m5C transferase in COAD and suggest that NSUN6 is a potential biomarker and target for this malignancy.
An accountant in the C‐suite: Chief Accounting Officers and asymmetric timely loss recognition
Authors: Kim Robert , Lee Bryan Byung‐Hee , Lee Jay Junghun 
Published: May 2024

AbstractWe study the role and influence of Chief Accounting Officers (CAOs) by examining the relation between the presence of a CAO on the top management team and asymmetric timely loss recognition (ATLR). Using large‐sample data from 10‐Ks and proxy statements of S&P 1500 firms, we find that the presence of a CAO is positively associated with the level of ATLR and that this positive relation is more pronounced when the Chief Financial Officer (CFO) does not have an accounting background. Our difference‐in‐differences analysis further indicates that the level of ATLR increases significantly following the initial appointments of CAOs. The results are robust to propensity score matching, alternative ATLR models, and various control variables. Collectively, our findings suggest that adding an accounting chief to the C‐suite has a significant impact on financial reporting practices.
Oxygen consumption rate of flatworms under the influence of wake‐ and sleep‐promoting neurotransmitters
Authors: Omond Shauni E. T. , Barker Robert G. , Sanislav Oana , Fisher Paul R. , Annesley Sarah J. , Lesku John A. 
Published: May 2024

AbstractFlatworms are among the best studied animal models for regeneration; however, they also represent an emerging opportunity to investigate other biological processes as well. For instance, flatworms are nocturnal and sleep during the day, a state that is regulated by sleep/wake history and the action of the sleep‐promoting neurotransmitter gamma‐aminobutyric acid (or GABA). Sleep is widespread across the animal kingdom, where it serves many nonexclusive functions. Notably, sleep saves energy by reducing metabolic rate and by not doing something more energetically taxing. Whether the conservation of energy is apparent in sleeping flatworms is unclear. We measured the oxygen consumption rate (OCR) of flatworms dosed with either (1) GABA (n = 29) which makes flatworms inactive or (2) dopamine (n = 20) which stimulates flatworms to move, or (3) day and night neurotransmitter‐free controls (n = 28 and 27, respectively). While OCR did not differ between the day and night, flatworms treated with GABA used less oxygen than those treated with dopamine, and less than the day‐time control. Thus, GABA affected flatworm physiology, ostensibly by enforcing energy‐conserving sleep. Evidence that dopamine increased metabolism was less strong. This work broadens our understanding of flatworm physiology and expands the phylogenetic applicability of energy conservation as a function of sleep.
Prognostic clinical decision support for pneumonia in the emergency department: A randomized trial
Authors: Williams Derek J. , Nian Hui , Suresh Srinivasan , Slagle Jason , Gradwohl Stephen , Johnson Jakobi , Stassun Justine , Reale Carrie , Just Shari L. , Rixe Nancy S. , Beebe Russ , Arnold Donald H. , Turer Robert W. , Antoon James W. , Sartori Laura F. , Freundlich Robert E. , Grijalva Carlos G. , Smith Joshua C. , Weitkamp Asli O. , Weinger Matthew B. , Zhu Yuwei , Martin Judith M. 
Published: May 2024

AbstractBackgroundHospitalization rates for childhood pneumonia vary widely. Risk‐based clinical decision support (CDS) interventions may reduce unwarranted variation.MethodsWe conducted a pragmatic randomized trial in two US pediatric emergency departments (EDs) comparing electronic health record (EHR)‐integrated prognostic CDS versus usual care for promoting appropriate ED disposition in children (<18 years) with pneumonia. Encounters were randomized 1:1 to usual care versus custom CDS featuring a validated pneumonia severity score predicting risk for severe in‐hospital outcomes. Clinicians retained full decision‐making authority. The primary outcome was inappropriate ED disposition, defined as early transition to lower‐ or higher‐level care. Safety and implementation outcomes were also evaluated.ResultsThe study enrolled 536 encounters (269 usual care and 267 CDS). Baseline characteristics were similar across arms. Inappropriate disposition occurred in 3% of usual care encounters and 2% of CDS encounters (adjusted odds ratio: 0.99, 95% confidence interval: [0.32, 2.95]). Length of stay was also similar and adverse safety outcomes were uncommon in both arms. The tool's custom user interface and content were viewed as strengths by surveyed clinicians (>70% satisfied). Implementation barriers include intrinsic (e.g., reaching the right person at the right time) and extrinsic factors (i.e., global pandemic).ConclusionsEHR‐based prognostic CDS did not improve ED disposition decisions for children with pneumonia. Although the intervention's content was favorably received, low subject accrual and workflow integration problems likely limited effectiveness. Clinical Trials Registration: NCT06033079.
Risk factors associated with escalation of care in a quaternary academic hospital at home program
Authors: Colt Cowdell Jed , Lopez Ellen , Haney Amy , Myers Luke , Coble Barbara , Heckman Michael G. , Moerer Ryan T. , Paulson Margaret R. , Maniaci Michael 
Published: May 2024

AbstractBackgroundHospital‐at‐home has become a more recognized way to care for patients requiring inpatient hospitalization. At times, these patients may require escalation of care (transfer from home back to the brick‐and‐mortar (BAM) hospital for ongoing hospitalization care needs), a process that has not been extensively studied.ObjectiveTo evaluate what patient factors contribute to escalations of care in the hospital‐at‐home delivery model.Designs, Settings, and ParticipantsWe conducted a retrospective review of all patients admitted to Mayo Clinic's Advanced Care at Home (ACH) program from January 1, 2022 to December 31, 2022.InterventionNone.Main Outcomes and MeasuresPatient information was collected via electronic health record including demographic, socioeconomic, and clinical status. The primary outcome was the of occurrence of an escalation.ResultsA total of 904 patients were included, of whom 80 (8.8%) required an escalation of care. In multivariable analysis, risk of an escalation was significantly higher for patients who were married or had a life partner (HR: 1.82, 95% CI: 1.05–3.23, p = .033) for patients admitted with procedure‐related disorders (HR: 2.61, 95% CI: 1.35–5.05, p = .005) and patients with an increased mortality risk score (HR [per each 1–category increase] = 1.86, 95% CI: 1.39–2.50, p < .001).
Fourth‐order inverse filter configuration using current differencing buffered amplifier
Authors: Ghosh Mourina , Mondal Pulak , Kumar Santosh 
Published: May 2024

AbstractThis article presents three different higher‐order inverse filter (IF) configurations using current differencing buffered amplifier (CDBA) as an active component and a few passive elements. The topology can be used to synthesize fourth‐order inverse low pass filter (FO‐ILPF), inverse band pass filter (FO‐IBPF), and inverse all‐pass filter (FO‐IAPF) using suitable admittance combinations. PSPICE simulations verify the functionality of the proposed IFs with the CMOS‐based CDBA using 180 nm technology. The theoretical analysis and simulated results are also carried out, which shows that they are in close agreement. The passive sensitivity analysis, non‐ideality analysis, Monte Carlo simulation, temperature analysis, percentage of total harmonic distortion (%THD), and noise analysis of the proposed filters are also performed. The proposed design has also been implemented using the current feedback operational amplifier (CFOA) as IC AD844AN to verify the functionality.
Evaluation of biogas production and bacterial load from co‐digestion of chicken manure with different types of household waste
Authors: Haque Mohammad Enamul , Ryndin Roman , Mang Heinz‐Peter , Kabir Humayun , Islam Mohammad Alimul 
Published: May 2024

AbstractBackgroundThe aim of this study was to evaluate the biogas production of chicken manure (CM) co‐digestion with different types of household waste (soft organic [SO] and food waste [FW]), as well as to evaluate the bacterial load of feeding stock and digested slurry samples before and after anaerobic digestion (AD). The experiment was carried out using lab‐based prototype digesters for co‐digestion of CM with different household wastes (5%). Three experimental groups (T1, T2, and T3) were designed using mixing ratios of SO:CM:H2O:inoculum (5:22.5:22.5:50), FW:CM:H2O:inoculum (5:22.5:22.5:50), and (SO + FW):CM:H2O:inoculum (2.5 + 2.5:22.5:22.5:50). The digesters were set at 28–34°C for 30 days for hydraulic retention time (HRT). Total viable count (TVC), Escherichia coli, and Salmonella spp. counts were determined using the spread plate technique.ResultsThe study revealed that the highest average cumulative biogas yield was achieved from T1 > T3 > T2, but the concentration of CH4 was found in T3 > T2 > T1. The biogas production between the three groups was statistically nonsignificant (p > 0.05) but the daily concentration of CH4 was found statistically significant (p < 0.05). The average concentration of CH4 and CO2 in biogas was found to be 30% and 68% for T1, 60% and 37% for T2, and 69% and 27% for T3. However, the H2S content was within the acceptable range. The bacterial load was decreased by 2–3 logs before and after AD, and this reduction was statistically significant (p < 0.05).ConclusionThe research found that the co‐digestion of CM with combined household wastes increased the methane concentration in biogas.
Extended distal femur resection: Megaprosthesis with telescopic bone allograft augmentation versus total femur prosthesis
Authors: Bruschi Alessandro , Cevolani Luca , Minerba Andrea , Conversano Davide , Falzetti Luigi , Pasini Stefano , Donati Davide M. 
Published: May 2024

AbstractBackground and ObjectiveOncological distal femur resections can leave a proximal femur too short to host a stem. Reconstructive techniques are then challenging. The purpose of the study is to compare implant survival, complication rate and MSTS of two different options.MethodsWe retrospectively divided 33 patients with primary bone tumours of distal femur in Group 1 (16 patients reconstructed with knee megaprosthesis with proximal bone augmentation, APC) and Group 2 (17 patients reconstructed with total femur prosthesis, TFP). Less than 12 cm of remaining proximal femur were planned for all resections.ResultsMSTS score at 2 years is 25 ± 5 for Group 1 and 19 ± 7 for Group 2 (confidence interval [C.I.] 95%, p = 0.02). At 5 years it is 27 ± 2 for Group 1 and 22 ± 6 for Group 2 (C.I. 95%, p = 0.047). Failure and complication rates are lower for Group 1, but no statistical significance was reached. In APC reconstruction, union at the host‐allograft junction was achieved in 16 out of 16 patients using the telescopic bone augmentation technique.ConclusionsAPC provides higher functional results compared to TFP after extended distal femur resection. In APC reconstruction, telescopic augmentation is excellent for achieving union at the host‐allograft junction.
Acne vulgaris in a 22‐year‐old cystic fibrosis patient treated with Elexacaftor‐Tezacaftor‐Ivacaftor and good clinical response to isotretinoin—A case report
Authors: Pfeiffer Isabelle , Berneburg Mark , Hopfner Zeljka , Niebel Dennis 
Published: May 2024

AbstractCystic fibrosis (CF) is a rare autosomal recessive genetic disorder that is now commonly treated with cystic fibrosis transmembrane conductance regulator (CFTR) modulators. Typical adverse events comprise new onset (drug‐induced) acneiform eruption as well as worsening of pre‐existing acne vulgaris. We present a case report of a young adult with rapid CFTR‐modulator‐induced worsening of pre‐existing acne vulgaris refractory to minocycline treatment, which resolved within 8 months of low dose isotretinoin therapy. Monthly laboratory monitoring of liver function, lipid levels and blood count were unremarkable in this case. The optimal treatment of acne vulgaris in CF‐patients and the management of drug‐induced acne remain a challenge. The latter may jeopardize drug adherence. CFTR‐modulators might be capable to induce acneiform skin lesions by altering electrolyte concentrations and sweat production with subsequential changes of the microbiome and follicular inflammatory response. The exact mechanism remains elusive at this point and warrants further investigation.
Full‐Parameter Symmetric Jones Matrix Construction and Non‐Orthogonal‐Polarization Multiplexed Wavefront Shaping Over a Lossy Metasurface
Authors: Guan Shengnan , Cheng Jierong , Tan Zhiyu , Xu Haifeng , Fan Fei , Chang Shengjiang 
Published: May 2024

AbstractAccurate full‐parameter construction of the Jones matrix is of great significance for encoding multiple functions in a single metasurface. Supercells composed of several elements are used for this purpose through coherent superposition. But all the elements in the reported studies should be lossless with near‐unity transmission, which limits the material system and restricts the Jones matrix construction in a unitary manner. Here a non‐unitary matrix decomposition method is proposed to build the supercell using a pair of 0°‐oriented rods and a pair of 45°‐oriented rods for on‐demand design of arbitrary symmetric Jones matrices. This method is applicable for lossy metasurfaces and offers straightforward physical guidance for structure design without optimization. The accuracy of the on‐demand Jones matrix generation is demonstrated by several 3D‐printed alumina metalenses with 3‐, 4‐, and 6‐channel polarization‐multiplexed focusing. The study opens a new pathway for non‐silicon meta‐optics and holds great potential for dynamic or switchable applications.
Recent Advances in the Fabrication and Performance Optimization of Polyvinyl Alcohol Based Vascular Grafts
Authors: Liu Yixuan , Gao Zichun , Yu Xinrong , Lin Wenjiao , Lian He , Meng Zhaoxu 
Published: May 2024

AbstractCardiovascular disease is one of the diseases with the highest morbidity and mortality rates worldwide, and coronary artery bypass grafting (CABG) is a fast and effective treatment. More researchers are investigating in artificial blood vessels due to the limitations of autologous blood vessels. Despite the availability of large‐diameter vascular grafts (Ø > 6 mm) for clinical use, small‐diameter vascular grafts (Ø < 6 mm) have been a challenge for researchers to overcome in recent years. Vascular grafts made of polyvinyl alcohol (PVA) and PVA‐based composites have excellent biocompatibility and mechanical characteristics. In order to gain a clearer and more specific understanding of the progress in PVA vascular graft research, particularly regarding the preparation methods, principles, and functionality of PVA vascular graft, this article discusses the mechanical properties, biocompatibility, blood compatibility, and other properties of PVA vascular graft prepared or enhanced with different blends using various techniques that mimic natural blood vessels. The findings reveal the feasibility and promising potential of PVA or PVA‐based composite materials as vascular grafts.
Hot corrosion behavior of Mo–9.0Si–8.0B
Authors: Beck Katharina , König Till , Case Abigail , Oskay Ceyhun , Galetz Mathias C. 
Published: May 2024

AbstractIn recent years, interest in Mo‐based alloys has increased significantly due to their promising high‐temperature behavior and their possible uses for industrial high‐temperature applications such as within turbines. An important corrosion mechanism in turbines is the sulfate salt‐induced attack of the structural materials, known as hot corrosion. Therefore, the Type I and II hot corrosion behavior of Mo–9.0Si–8.0B was investigated at 700°C and 900°C for 24 and 100 h. The Mo‐based alloy showed severe degradation, but not by sulfates. Thus, the underlying hot corrosion mechanism through molybdate fluxing, which is accompanied by Mo oxide evaporation, is discussed in detail. At the higher temperature, the MoO3 evaporation becomes predominant, leaving behind a Si‐glass with molybdate inclusions.
Avengers assemble: Avenger philanthropy as the new gift opportunity for nonprofit organizations
Authors: Mitchell Sarah‐Louise 
Published: May 2024

AbstractThis conceptual paper extends theories of gift giving behavior through identifying and defining the emerging phenomenon of Avenger Philanthropy. This manifests when people make individual monetary donations to nonprofit organizations (NPOs) to achieve a collective sense of moral grandstanding, usually underpinned by humor. For the first time, the paper makes sense of this phenomenon theoretically through drawing on a wide range of literature including gift giving, game theory and consumer psychology, and as a result, identifies seven distinctive hallmarks. The paper maps the importance of public expression of personal values, amplified through social media, together with risks for the NPO that benefits from the donations. Emotion underpins the giving behavior, both moral outrage and humor. This investigation contributes to the gift giving literature by identifying, mapping and anchoring current actions that potentially have far reaching consequences for future research and for nonprofit practice.
COVID‐19 and credit risk variation across banks: International insights
Authors: Acheampong Albert , Ibeji Ngozi , Danso Albert 
Published: May 2024

AbstractThis paper focuses on utilizing non‐performing loans (NPLs) as the primary indicator of credit risk to analyze how various bank and country‐level characteristics influence changes in credit risk within and between banks across China, Europe, and the U.S. during the COVID‐19 period. Over 4,959 bank‐quarter observations (from Q4 2019 to Q4 2021), it becomes evident that COVID‐19 significantly contributes to the variation in NPLs, underscoring its adverse impact on credit risk. This pattern is consistent across all countries; however, Chinese banks exhibit more robust capabilities in managing credit risk exposure compared to their European and U.S. counterparts. These findings offer significant implications for policymakers, investors, and regulators who are concerned about the repercussions of global pandemics on financial institutions.
Enhancing synergistic performance through implicit incentive contracts: Addressing the “talent dilemma” in the public sector
Authors: Guo Jiayuan , Du Jianbo , Li Ming , Chen Xu , Bian Yijie 
Published: May 2024

AbstractBecause of the conflict between the traditional public sector values of egalitarianism and new public management, talent management (TM) in the public sector is more difficult to implement under resource constraints. Equity and efficiency in China's public sector are squeezed out of each other under egalitarianism, resulting in the “ talent dilemma” in which talent works more but does not get more. The “talent dilemma” leads to the fact that it is very attractive for talents to hide their abilities and reduce their efforts in the public sector. In this paper, from the perspective of the “talent dilemma”, we study the contract design problem of the coexistence of heterogeneous talent's adverse selection and moral hazard in the public sector. Specifically, an incentive model combining exclusive and inclusive TM factors under information asymmetry is constructed. The optimal incentive contract is designed to motivate heterogeneous talents to display true information about their abilities and to maintain a maximized level of effort. The results of the study show that the optimal incentive contract can realize the role of information screening and break the “talent dilemma”. These findings provide a theoretical basis for the reform of incentive mechanisms in the public sector.