bluuebunny/crossref_metadata_2025_split huggingface dataset:
Turnover Intention Among Hospital‐Based Registered Nurses in the Eastern Caribbean
Authors: Lansiquot Beverley Anne , Tullai‐McGuinness Susan , Madigan Elizabeth 
Published: April 2012

AbstractPurpose: Vacancy rates for nurses in the English‐speaking Caribbean are estimated at 30% with turnover typically associated with migration. The purpose of this study was to describe the characteristics of hospital‐based registered nurses (RNs) in the sub‐region, their practice environment and turnover intention in two and five years, respectively, and to determine the relationships among practice environment characteristics and turnover intention.Design: A descriptive correlational design was used with self‐reported questionnaires from a convenience sample of 301 RNs working in hospitals in four English speaking Eastern Caribbean countries. Single‐item visual analog scales (VAS) were used to measure turnover intention in 2 years and 5 years. The Practice Environment Scale of the Nursing Work Index (PES‐NWI) measured the characteristics in the practice environment.Findings: The mean age of the nurses was 32.5 (SD= 6.75) years. Most nurses (58.8%) were single and 91.4% had relatives living abroad. Nurses scored three PES‐NWI subscales < 2.5, indicating a less positive practice environment: resource adequacy, nurse participation in hospital affairs, and nurse managers’ ability, leadership, and support. The subscale for collegial nurse‐physician relations received the best rating (mean = 2.61, SD= .62). For 2‐year intention to leave, the mean rating on the 100‐mm VAS was 63.2, while that for the 5‐year intention to leave was 65.6. No significant correlations were found among four of the five PES‐NWI subscales and turnover intention in 2 and 5 years.Conclusions: The practice environment, while generally unfavorable, is not associated with the nurses’ intention to leave their jobs. These findings support the current policy position that calls for managing turnover among nurses. Nursing and health system administrators should assess, plan, and implement workforce policies to slow the outflow of nurses.Clinical Relevance: Initiatives to improve the work environment and the delivery of high‐quality care are important to RNs in the Eastern Caribbean. Managing the negative impact of continuous outflow of nurses through turnover requires long‐term coordinated policy and human resource development and management initiatives to sustain the supply of RNs in the subregion.
Deposition of Preferred‐Orientation ZnO Films on the Lead‐Free Ceramic Substrates and its Effects on the Properties of Surface Acoustic Wave Devices
Authors: Chan I‐Hao , Chang Jen‐Chuan , Sun Chieh‐Tze , Houng Mau‐Phon , Chu Sheng‐Yuan 
Published: April 2012

A study of the structure based on the ZnO layers and NKN‐SrTiO3 (NKN‐ST) ceramic substrates with different sputtering conditions to deposit ZnO films is presented. Poly‐crystal ZnO films with c‐axis (002) orientation have been successfully grown on the NKN‐ST ceramic substrates by RF magnetron sputtering technique. The deposited films were characterized as a function of oxygen‐argon gas flow ratio, RF power, sputtering pressure, and depositing time. The ZnO films with strong (002) orientation are obtained under a base pressure of 20 mTorr, containing 40% oxygen and 60% argon at RF power of 60 W. Crystalline structures and surface roughness characteristics of the films were investigated by using XRD analysis, SEM, and AFM measurements. It shows that the preferred oriented ZnO film is beneficial for improving the electromechanical coupling coefficient (k2) of Surface Acoustic Wave (SAW) device. The velocity, k2, and temperature coefficient of frequency of the ZnO/IDT/NKN‐ST SAW device properties are 3120 m/s, 4.20%, and −320, respectively.
Surgical‐pathologic risk factors of pelvic lymph node metastasis in stage Ib1‐IIb cervical cancer
Authors: LI DONGLIN , CAI JING , KUANG YAN , CAO JIN , WANG ZEHUA 
Published: April 2012

AbstractObjective. To study the distribution characteristics and risk factors of cervical cancer lymph node metastasis (LNM). Design. Retrospective study. Setting. Department of Obstetrics and Gynecology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology and Affiliated Hospital to Zunyi Medical College. Population. 404 women diagnosed with cervical cancer FIGO stage Ib1‐IIa who underwent primary radical surgery and 104 women with Ib2‐IIb tumors treated with neoadjuvant chemotherapy (NACT) before surgery. Methods. Clinicopathological data were collected and analyzed. Main outcome measures. Incidence of infiltration, metastasis and pelvic LNM. Results. In women without NACT, the incidence of infiltration, metastasis and LNM was 7.2, 17.6 and 15.8%, respectively. Metastasis and LNM were significantly associated with advanced FIGO stage and poorer histological grade. The incidence of multiple metastatic lymph nodes (MLNs), bilateral LNM, skip LNM, LNM in primary group and LNM in secondary group was 6.2, 3.0, 6.2%, 11.4 and 4.5%, respectively. Of the 111 MLNs, 13 (11.7%) were common iliac lymph nodes. In the NACT group, infiltration, metastasis and LNM were observed in 10 (9.6%), 24 (23.1%) and 21 (20.1%) of 104 women, respectively. Metastasis and LNM were significantly correlated with moderate cell differentiation. Conclusion. High LNM risk is expected in tumors of IIa stage or higher and in moderately differentiated tumors. Skip metastasis and common iliac LNM are relatively common and therefore should not be neglected. Our results suggest that standardized and complete pelvic lymph node dissection under surgery is an important measure to ensure a therapeutic effect.
Early trauma and familial risk in the development of the extended psychosis phenotype in adolescence
Authors: Wigman J. T. W. , van Winkel R. , Ormel J. , Verhulst F. C. , van Os J. , Vollebergh W. A. M. 
Published: April 2012

Wigman JTW, van Winkel R, Ormel J, Verhulst FC, van Os J, Vollebergh WAM. Early trauma and familial risk in the development of the extended psychosis phenotype in adolescence.Objective:  Both genetic and environmental factors are thought to play a role in the development of psychotic outcomes; however, their respective contributions over time, including possible developmental interactions, remain largely unknown.Method:  The contribution of parental general and psychotic psychopathology as proxies of genetic risk to the development of subthreshold psychosis and its hypothesized interaction with childhood trauma were studied in a general population sample of 2230 adolescents, followed from age 10–16 years. Outcome measures were: i) level of psychotic experiences at age 16 years and ii) persistence of such experiences over the total follow‐up period.Results:  General parental psychopathology was associated with CAPE score (OR = 1.08; P < 0.043 for highest quintile) and suggestively predicted psychosis persistence (OR, 1.16; P < 0.072). Psychotic parental psychopathology was suggestively associated with CAPE score (OR, 2.25; P < 0.063 for highest quintile), predicted membership of the Persistent group (OR, 3.72; P < 0.039) and suggestively predicted membership of the Decreasing group (OR 2.04; P < 0.051). Childhood trauma was associated with CAPE score and with all developmental trajectories of subclinical psychosis. No evidence was found for an interaction between trauma and parental psychopathology.Conclusion:  The development and persistence of subthreshold psychotic symptoms may be conditional on non‐interacting proxy genetic and environmental influences.
Effects of drop‐out on efficacy estimates in five Cochrane reviews of popular antipsychotics for schizophrenia
Authors: Hutton P. , Morrison A. P. , Yung A. R. , Taylor P. J. , French P. , Dunn G. 
Published: April 2012

Hutton P, Morrison AP, Yung AR, Taylor PJ, French P, Dunn G. Effects of drop‐out on efficacy estimates in five Cochrane reviews of popular antipsychotics for schizophrenia.Objective:  Our aim was to find out how Cochrane reviews of five popular or frequently prescribed second‐generation antipsychotics in the UK (olanzapine, risperidone, quetiapine, amisulpride and aripiprazole) approached the problem of high drop‐out in placebo‐controlled trials.Method:  We examined the following: (i) whether reviews included data from studies with a level of drop‐out exceeding their stated exclusion criterion; (ii) the level of missing data each efficacy outcome in each review relied upon; and (iii) impact of excluding studies with high drop‐out.Results:  All reviews included data they stated they would exclude because of unacceptable levels of attrition, four (risperidone, olanzapine, amisulpride, aripiprazole) without clear acknowledgement or justification. Several reviews also excluded data from a number of relatively low‐attrition studies because of missing standard deviations.Conclusion:  Cochrane reviews of five popular antipsychotics for schizophrenia misrepresented the available evidence on their efficacy. The impact of including high‐attrition studies was difficult to quantify because of the exclusion of relevant low‐attrition studies. Further analysis of the efficacy of these drugs in studies with acceptable rates of attrition is required. To reduce the problem of high attrition, trialists should gather follow‐up data from people who leave the double‐blind process early.
Yoga in schizophrenia: a systematic review of randomised controlled trials
Authors: Vancampfort D. , Vansteelandt K. , Scheewe T. , Probst M. , Knapen J. , De Herdt A. , De Hert M. 
Published: April 2012

Vancampfort D, Vansteelandt K, Scheewe T, Probst M, Knapen J, De Herdt A, De Hert M. Yoga in schizophrenia: a systematic review of randomised controlled trials.Objective:  The objective of this systematic review was to assess the effectiveness of yoga as a complementary treatment on general psychopathology, positive and negative symptoms and health‐related quality of life (HRQL) for people with schizophrenia.Method:  Randomised controlled trials (RCTs) were considered whether they investigated a yoga intervention in patients with schizophrenia. The selection of studies, data extraction and quality assessment were performed independently by two reviewers.Results:  Only three RCTs met the inclusion criteria. Lower Positive and Negative Syndrome Scale (PANSS) total scores and subscale scores for positive and negative symptoms were obtained after yoga compared with exercise or waiting list control conditions. In the same way, the physical, psychological, social and environmental HRQL as measured with the abbreviated version of the World Health Organization Quality of Life questionnaire (WHOQOL‐BREF) increased more significantly after yoga than after exercise or waiting list control conditions. None of the RCTS encountered adverse events. Dose–response relationships could, however, not be determined.Conclusion:  Although the number of RCTs included in this review was limited, results indicated that yoga therapy can be an useful add‐on treatment to reduce general psychopathology and positive and negative symptoms. In the same way, HRQL improved in those antipsychotic‐stabilised patients with schizophrenia following yoga.
Occupational food‐related hand dermatoses seen over a 10‐year period
Authors: Vester Lotte , Thyssen Jacob P. , Menné Torkil , Johansen Jeanne Duus 
Published: April 2012

Background. Protein contact dermatitis was originally defined in 1976 by Hjorth and Roed‐Petersen as a distinct kind of dermatitis seen in patients with occupational food contact. Even though occupational skin diseases are frequent in Denmark, little attention has been paid to protein contact dermatitis, and the frequency is unknown.Objectives. To evaluate the frequency of occupational food‐related hand dermatoses and test results in patients occupationally exposed to foods.Materials and Methods. This was a retrospective study based on examinations, including skin prick testing and patch testing, performed at the Department of Dermato‐Allergology, Gentofte University Hospital, Denmark between 2001 and 2010.Results. Of all patients (n = 372), 57.0% had irritant contact dermatitis, 22.0% had protein contact dermatitis, 2.4% had contact urticaria, and 1.8% had allergic contact dermatitis. A suggestion for diagnostic criteria is presented. Frequent risk occupations were cooking in restaurants, baking, and kitchen work. Substantially more patients reacted in skin prick testing with fresh foods than with food extracts.Conclusion. Protein contact dermatitis is a frequent disorder among patients who professionally handle foods, and should be considered to be a distinct clinical entity. When diagnosing protein contact dermatitis and in other food‐related skin prick testing procedures, it is important to include fresh foods.
Sesquiterpene lactone mix as a diagnostic tool for Asteraceae allergic contact dermatitis: chemical explanation for its poor performance and Sesquiterpene lactone mix II as a proposed improvement
Authors: Jacob Mathias , Brinkmann Jürgen , Schmidt Thomas J. 
Published: April 2012

Background. Two preparations are currently in use for the diagnosis of allergic contact dermatitis caused by Asteraceae: (i) Sesquiterpene lactone (SL) mix [three pure sesquiterpene lactones (STLs)], whose use has been questioned, owing to an insufficient rate of true‐positive results; and (ii) Compositae mix, consisting of five Asteraceae extracts, which is problematic because of lack of standardization and questionable reproducibility.Objectives. To analyse the reasons for the narrow sensitivity of SL mix from a chemoinformatic point of view, and to propose a solution by rational selection of alternative constituents for a new SL mix II covering a broader cohort of allergic patients.Materials/methods. Structural and biological information on allergenic STLs was retrieved from databases and the literature, and molecular modelling and chemoinformatic computations were performed.Results. An explanation for the insufficient hit rate of SL mix is that the three constituents possess extremely similar molecular structures/properties and do not represent well the structural diversity of allergenic STLs. STLs that are known as constituents of Compositae mix plants show much a wider diversity, which explains the higher positive rate.Conclusions. On the basis of their positions in chemical property space, a new collection of STLs that more evenly cover the overall structural diversity spectrum is proposed. SL mix II is likely to detect a larger number of patients sensitized to Asteraceae.
Use of acronyms in the patient dental record
Authors: Pepper K , Robinson FG 
Published: April 2012

To cite this article:   Int J Dent Hygiene  DOI: 10.1111/j.1601‐5037.2012.00547.x  Pepper K, Robinson FG. Use of acronyms in the patient dental record.Abstract:The patient dental record is a legal document that captures the history of patient care for a particular patient. This article references the American Dental Association's listing of common dental abbreviations, symbols and acronyms, which aid in establishing uniformity for clinicians.
Comparison of canine core bone marrow biopsies from multiple sites using different techniques and needles
Authors: Abrams‐Ogg Anthony C.G. , Defarges Alice , Foster Robert A. , Bienzle Dorothee 
Published: April 2012

BackgroundCommonly used 11 or 13ga needles are relatively large for collection of bone marrow (BM) biopsies from small dogs.ObjectivesThe aims of this study were to assess ease of BM collection and quality of specimens obtained from small dogs using 13 and 15ga needles and to determine if specimen encasement would improve quality.MethodsHumeral and iliac biopsies obtained from 17 Beagle dogs with a 15ga needle and a power driver were compared with humeral biopsies obtained with a 13ga Jamshidi needle. Ease of collection (scored as 1 [very difficult] to 5 [very easy] for 3 components of collection with scores summed), section quality (scored as 1 [poor] to 5 [good]), and lesions at collection sites were scored. Quality of additional humeral biopsies obtained with a 15ga needle and wrapped in tissue paper prior to fixation was assessed.ResultsUse of a 15ga needle to obtain a humeral BM biopsy was significantly easier (mean score ± SD = 13.6 ± 1.7) than obtaining humeral BM using a 13ga needle (11.4 ± 1.6; P < .001) or obtaining iliac BM using a 15ga needle (10.9 ± 2.0, P < .001). Quality of humeral biopsies obtained with a 13ga needle (3.9 ± 1.2) was better than for biopsies of the humerus (1.9 ± 1.3, P < .001) or ilium (1.4 ± 0.6, P < .001) using a 15ga needle. Only sites sampled with a 13ga needle were identifiable grossly after the procedure. In most biopsies, cell density and cellularity were lower when a 15ga needle was used. Paper‐wrapping of biopsies did not improve quality.ConclusionsIn small dogs, collection of humeral BM biopsies using a 15g needle is feasible and more easily accomplished than collection using a 13ga needle. Hematopoiesis may be underestimated in specimens collected using the smaller needle.
A Reverse Genetics Approach To Study Feline Infectious Peritonitis
Authors: Tekes Gergely , Spies Danica , Bank-Wolf Barbara , Thiel Volker , Thiel Heinz-Jürgen 
Published: April 2012

ABSTRACTFeline infectious peritonitis (FIP) is a lethal immunopathological disease caused by feline coronaviruses (FCoVs). Here, we describe a reverse genetics approach to study FIP by assessing the pathogenicity of recombinant type I and type II and chimeric type I/type II FCoVs. All recombinant FCoVs established productive infection in cats, and recombinant type II FCoV (strain 79-1146) induced FIP. Virus sequence analyses from FIP-diseased cats revealed that the 3c gene stop codon of strain 79-1146 has changed to restore a full-length open reading frame (ORF).
Pathogenicity and Transmission in Pigs of the Novel A(H3N2)v Influenza Virus Isolated from Humans and Characterization of Swine H3N2 Viruses Isolated in 2010-2011
Authors: Kitikoon Pravina , Vincent Amy L. , Gauger Phillip C. , Schlink Sarah N. , Bayles Darrell O. , Gramer Marie R. , Darnell Daniel , Webby Richard J. , Lager Kelly M. , Swenson Sabrina L. , Klimov Alexander 
Published: April 2012

ABSTRACT

Swine influenza virus (SIV) H3N2 with triple reassorted internal genes (TRIG) has been enzootic in Unites States since 1998. Transmission of the 2009 pandemic H1N1 (pH1N1) virus to pigs in the United States was followed by reassortment with endemic SIV, resulting in reassorted viruses that include novel H3N2 genotypes (rH3N2p). Between July and December 2011, 12 cases of human infections with swine-lineage H3N2 viruses containing the pandemic matrix (pM) gene [A(H3N2)v] were detected. Whole-genome analysis of H3N2 viruses isolated from pigs from 2009 to 2011 sequenced in this study and other available H3N2 sequences showed six different rH3N2p genotypes present in the U.S. swine population since 2009. The presence of the pM gene was a common feature among all rH3N2p genotypes, but no specific genotype appeared to predominate in the swine population. We compared the pathogenic, transmission, genetic, and antigenic properties of a human A(H3N2)v isolate and two swine H3N2 isolates, H3N2-TRIG and rH3N2p. Our
in vivo
study detected no increased virulence in A(H3N2)v or rH3N2p viruses compared to endemic H3N2-TRIG virus. Antibodies to cluster IV H3N2-TRIG and rH3N2p viruses had reduced cross-reactivity to A(H3N2)v compared to other cluster IV H3N2-TRIG and rH3N2p viruses. Genetic analysis of the hemagglutinin gene indicated that although rH3N2p and A(H3N2)v are related to cluster IV of H3N2-TRIG, some recent rH3N2p isolates appeared to be forming a separate cluster along with the human isolates of A(H3N2)v. Continued monitoring of these H3N2 viruses is necessary to evaluate the evolution and potential loss of population immunity in swine and humans.
Oct4
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Stem/Progenitor Swine Lung Epithelial Cells Are Targets for Influenza Virus Replication
Authors: Khatri Mahesh , Goyal Sagar M. , Saif Yehia M. 
Published: April 2012

ABSTRACT
We isolated stem/progenitor epithelial cells from the lungs of 4- to 6-week-old pigs. The epithelial progenitor colony cells were surrounded by mesenchymal stromal cells. The progenitor epithelial colony cells expressed stem cell markers such as octamer binding transcription factor 4 (Oct4) and stage-specific embryonic antigen 1 (SSEA-1), as well as the epithelial markers pancytokeratin, cytokeratin-18, and occludin, but not mesenchymal (CD44, CD29, and CD90) and hematopoietic (CD45) markers. The colony cells had extensive self-renewal potential and had the capacity to undergo differentiation to alveolar type I- and type II-like pneumocytes. Additionally, these cells expressed sialic acid receptors and supported the active replication of influenza virus, which was accompanied by cell lysis. The lysis of progenitor epithelial cells by influenza virus may cause a marked reduction in the potential of progenitor cells for self renewal and for their ability to differentiate into specialized cells of the lung. These observations suggest the possible involvement of lung stem/progenitor cells in influenza virus infection.
Role for TBC1D20 and Rab1 in Hepatitis C Virus Replication via Interaction with Lipid Droplet-Bound Nonstructural Protein 5A
Authors: Nevo-Yassaf Inbar , Yaffe Yakey , Asher Meital , Ravid Orly , Eizenberg Sharon , Henis Yoav I. , Nahmias Yaakov , Hirschberg Koret , Sklan Ella H. 
Published: April 2012

ABSTRACT
Replication and assembly of hepatitis C virus (HCV) depend on the host's secretory and lipid-biosynthetic machinery. Viral replication occurs on endoplasmic reticulum (ER)-derived modified membranes, while viral assembly is thought to occur on lipid droplets (LDs). A physical association and coordination between the viral replication and assembly complexes are prerequisites for efficient viral production. Nonstructural protein 5A (NS5A), which localizes both to the ER and LDs, is an ideal candidate for this function. Here, the interaction of NS5A with host cell membranes and binding partners was characterized in living cells. The binding of NS5A to LDs is apparently irreversible, both in HCV-infected cells and when ectopically expressed. In HCV-infected cells, NS5A fluorescence was observed around the LDs and in perinuclear structures that were incorporated into a highly immobile platform superimposed over the ER membrane. Moreover, TBC1D20 and its cognate GTPase Rab1 are recruited by NS5A to LDs. The NS5A-TBC1D20 interaction was shown to be essential for the viral life cycle. In cells, expression of the Rab1 dominant negative (Rab1DN) GTPase mutant abolished steady-state LDs. In infected cells, Rab1DN induced the elimination of NS5A from viral replication sites. Our results demonstrate the significance of the localization of NS5A to LDs and support a model whereby its interaction with TBC1D20 and Rab1 affects lipid droplet metabolism to promote the viral life cycle.