bluuebunny/crossref_metadata_2025_split huggingface dataset:
Characterization of the bed nucleus of the stria terminalis in the forebrain of anuran amphibians
Authors: Moreno Nerea , Morona Ruth , López Jesús M. , Domínguez Laura , Joven Alberto , Bandín Sandra , González Agustín 
Published: June 2011

AbstractMajor common features have been reported for the organization of the basal telencephalon in amniotes, and most characteristics were thought to be acquired in the transition from anamniotes to amniotes. However, gene expression, neurochemical, and hodological data obtained for the basal ganglia and septal and amygdaloid complexes in amphibians (anamniotic tetrapods) have strengthened the idea of a conserved organization in tetrapods. A poorly characterized region in the forebrain of amniotes has been the bed nucleus of the stria terminalis (BST), but numerous recent investigations have characterized it as a member of the extended amygdala. Our study analyzes the main features of the BST in anuran amphibians to establish putative homologies with amniotes. Gene expression patterns during development identified the anuran BST as a subpallial, nonstriatal territory. The BST shows Nkx2.1 and Lhx7 expression and contains an Islet1‐positive cell subpopulation derived from the lateral ganglionic eminence. Immunohistochemistry for diverse peptides and neurotransmitters revealed that the distinct chemoarchitecture of the BST is strongly conserved among tetrapods. In vitro tracing techniques with dextran amines revealed important connections between the BST and the central and medial amygdala, septal territories, medial pallium, preoptic area, lateral hypothalamus, thalamus, and prethalamus. The BST receives dopaminergic projections from the ventral tegmental area and is connected with the laterodorsal tegmental nucleus and the rostral raphe in the brainstem. All these data suggest that the anuran BST shares many features with its counterpart in amniotes and belongs to a basal continuum, likely controlling similar reflexes, reponses, and behaviors in tetrapods. J. Comp. Neurol. 520:330–363, 2012. © 2011 Wiley Periodicals, Inc.
Requirement for the paired‐like homeodomain transcription factor VSX1 in type 3a mouse retinal bipolar cell terminal differentiation
Authors: Shi Zhiwei , Jervis Drew , Nickerson Philip E.B. , Chow Robert L. 
Published: June 2011

AbstractRetinal bipolar cells make up a class of at least 11 distinct interneurons that have been classified through morphological and molecular approaches. Previous work has shown that the paired‐like homeodomain transcription factor Vsx1 is essential for the proper development of a subset of these interneurons. In Vsx1‐null mice, bipolar cells are properly specified but exhibit terminal differentiation defects characterized by reduced expression of OFF bipolar cell markers and defects in OFF visual signaling. Here, we further examined the role of Vsx1 in OFF bipolar cells using recently identified cell‐type‐specific markers. In contrast to its previously characterized expression in type 2 OFF bipolar cells, Vsx1 expression was not detected in type 3 OFF bipolar cells, by either immunohistological or transgenic reporter labeling approaches. This observation was unexpected given previous findings that Cabp5 immunolabeling of type 3 bipolar cell axon terminals is reduced in Vsx1‐null mice. However, we observed reduced levels of the type 3a bipolar cell marker hyperpolarization‐activated and cyclic nucleotide‐gated channel 4 (HCN4) in Vsx1‐null mice, which is consistent with a requirement for Vsx1 in type 3 bipolar cell differentiation. In contrast, expression of the type 3b bipolar cell marker regulatory subunit RII‐beta of protein kinase A was unchanged. Despite the absence of Vsx1 in mature type 3 bipolar cells, colabeling of Vsx1 and HCN4 was observed at postnatal stages. These findings reveal a role for Vsx1 in type 3a bipolar cells and suggest that Vsx1 function is required transiently in this cell type during the postnatal period. J. Comp. Neurol., 2012. © 2011 Wiley Periodicals, Inc.
Active optimistic and distributed message logging for message‐passing applications
Authors: Ropars Thomas , Morin Christine 
Published: June 2011

SUMMARYMessage logging is an attractive solution to provide fault tolerance for message‐passing applications because it is more scalable than coordinated checkpointing. Sender‐based message logging is a well‐known optimization that allows the saving of message payload in the sender memory. Thus, only message reception events have to be logged reliably by using an event logger. This paper proposes solutions to further improve message logging protocol scalability. In existing works on message logging, the event logger has always been considered as a centralized process. We propose a distributed event logger that takes advantage of multi‐core processors that are to be executed in parallel with application processes, leveraging the volatile memory of the nodes to save events reliably. We also propose the combination of our distributed event logger and O2P, an active optimistic message logging protocol using a gossip‐based protocol to disseminate information on new stable events. Our distributed event logger and O2P are implemented in the Open MPI library. Our results show the following: (i) distributed event logging improves message logging protocol scalability and (ii) using O2P with a distributed event logger provides an efficient and scalable fault‐tolerant solution for message‐passing applications. Copyright © 2011 John Wiley & Sons, Ltd.
Graphics processing unit‐based triangulations of Blinn molecular surfaces
Authors: Dias Sérgio E.D. , Gomes Abel J.P. 
Published: June 2011

SUMMARYComputing the surface of a molecule (e.g., a protein) plays an important role in the analysis of its geometric structure as needed in the study of interactions between proteins, protein folding, protein docking, and so forth. There are a number of algorithms for the computation of molecular surfaces and their triangulations, but only a few take advantage of graphics processing unit computing. This paper describes a graphics processing unit‐based marching cubes algorithm to triangulate molecular surfaces. In the end of the paper, a performance analysis of three implementations (i.e., serial CPU, CUDA, and OpenCL) of the marching cubes‐based triangulation algorithm takes place as a way to realize beforehand how molecular surfaces can be rendered in real‐time in the future. Copyright © 2011 John Wiley & Sons, Ltd.
Generation of transgenic dogs that conditionally express green fluorescent protein
Authors: Kim Min Jung , Oh Hyun Ju , Park Jung Eun , Kim Geon A. , Hong So Gun , Jang Goo , Kwon Mo Sun , Koo Bon Chul , Kim Teoan , Kang Sung Keun , Ra Jeong Chan , Ko CheMyong , Lee Byeong Chun 
Published: June 2011

AbstractTwo puppies, carrying an inducible eGFP transgene, delivered from the Tet‐on eGFP mother reported in Kim et al in this issue.
VSS robust adaptive control including a self‐tuning controller for a rotary inverted pendulum
Authors: Hirata Hiroshi , Takabe Tomohiro , Anabuki Masatoshi , Ouchi Shigeto 
Published: June 2011

AbstractThere are many publications on the stabilization of an inverted pendulum because it is a typical unstable system and is well used as an example to verify many control theories. However, few approaches consider the inverted pendulum as an unknown parameter system. This paper proposes a new VSS (Variable Structure System) robust adaptive control system including a self‐tuning controller for a rotary inverted pendulum all of whose parameters are unknown. The control system provides two kinds of adaptive controllers, and stabilization of the inverted pendulum is achieved by separating the system into two parts, the pendulum and the rotary arm. The rotational angle of the pendulum is stabilized by a tracking‐type VSS adaptive control method, and the rotary arm is simultaneously stabilized by an STC (self‐tuning control) system that assures the boundary reference angle of the pendulum. It is then not sufficient to construct an STC system using only the adjustable parameters of the VSS adaptive control system. Therefore, all basic parameters are recursively estimated in order to realize the STC system by using the least squares parameter adaptive law, and this is achieved by superimposing the perturbation signal on the stable adaptive control input over a limited short interval. Furthermore, the STC system designs an LQ controller by developing an efficient QR method for real‐time operation. Finally, the validity of the proposed system is demonstrated by numerical simulations and practical experimental results. © 2011 Wiley Periodicals, Inc. Electron Comm Jpn, 94(6): 48–58, 2011; Published online in Wiley Online Library (wileyonlinelibrary.com). DOI 10.1002/ecj.10179
Optimal design of IIR filters using linear semi‐indefinite programming method
Authors: Yamazaki Takayuki , Suyama Kenji 
Published: June 2011

AbstractAn optimal design method for stable IIR (Infinite Impulse Response) filters under the min‐max criterion is proposed. The design problem considered is the complex Chebyshev approximation of a rational function including the stability constraint. We formulate this problem as a problem of real linear semi‐infinite programming problem using the real rotation theorem. The problem is solved by the three‐phase method; one of the methods is used for solving semi‐infinite programming problems. The three‐phase method includes three operations. In the first operation, some active constraint candidates are selected by the iterative simplex method. Next, the second operation integrates some degenerate constraints. In the third operation, the approximate solution obtained up to the second operation is adjusted so as to satisfy the optimality condition. The filters designed by the method are found to be more precise than those designed by the conventional method. Several design examples are presented to demonstrate the effectiveness of the proposed method. © 2011 Wiley Periodicals, Inc. Electron Comm Jpn, 94(6): 17–23, 2011; Published online in Wiley Online Library (wileyonlinelibrary.com). DOI 10.1002/ecj.10330
Autonomous implant sensor position measurement using human voxel data
Authors: Kobayashi Hiroyuki , Hamagami Tomoki 
Published: June 2011

AbstractA new autonomous implant sensor positioning measurement technique is discussed. The goal of this study is to develop ubiquitous medical systems with autonomous nano‐medical sensors and robots. The key to achieving the goal is to establish autonomous positioning measurement for these implant objects without imposing a burden on patients. For this purpose, this study proposes autonomous positioning measurement with human voxel data. The technique combines two algorithms: autonomous distributed measurement of sensors with Sammon's map, which is a nonlinear mapping algorithm, and a voxel human model clustered with the propagation characteristics of human tissue. A simulation experiment shows that the proposed technique makes possible precise positioning measurement in a heterogeneous propagation environment in the human body. © 2011 Wiley Periodicals, Inc. Electron Comm Jpn, 94(6): 1–9, 2011; Published online in Wiley Online Library (wileyonlinelibrary.com). DOI 10.1002/ecj.10336
A model‐based method to design an application common platform for enterprise information systems
Authors: Ishihara Akira , Furuta Hirohisa , Yamaoka Takayuki , Seo Kazuo , Nishida Shogo 
Published: June 2011

AbstractThis paper presents a model‐based method to design a software development platform for enterprise information systems. We call it an application common platform, ACP. ACP wraps existing reusable software assets to hide their details from application developers and provide domain level API (Application Programming Interface), so that reusability of software assets and productivity of applications are improved. In this paper, we present a software architecture which organizes applications, ACP, and software assets and illustrate the development of ACP. In particular, we present transformation rules used to derive ACP design models from both application design models and software assets design models. We have evaluated our proposed method through case studies of the development of enterprise information systems. Our proposed method was found to reduce development costs by 20% compared to the estimated costs. © 2011 Wiley Periodicals, Inc. Electr Eng Jpn, 176(3): 37–51, 2011; Published online in Wiley Online Library (wileyonlinelibrary.com). DOI 10.1002/eej.21166
Multiparameter grouping delineates heterogeneous populations of human IL‐17 and/or IL‐22 T‐cell producers that share antigen specificities with other T‐cell subsets
Authors: Larsen Martin , Arnaud Laurent , Hié Miguel , Parizot Christophe , Dorgham Karim , Shoukry Mohamed , Kemula Mathilde , Barete Stéphane , Derai David , Sauce Delphine , Amoura Zahir , Pène Jérôme , Yssel Hans , Gorochov Guy 
Published: June 2011

AbstractThe ontogenic relationship between pro‐inflammatory populations of interleukin‐17 (IL‐17A)‐ and/or IL‐22‐producing T cells and other T‐cell subsets is currently unclear in humans. To appreciate T helper cell‐lineage commitment, we combined cytokine production profiles of in vitro expanded T‐cell clones with T‐cell receptor (TCR) clonotypic signatures. Moreover, ex vivo cytokine production profiles at the single‐cell level were analyzed using an original approach based on the hierarchical cluster analysis of multiparametric flow cytometry data. These combined approaches enabled the delineation of distinct functional T‐cell subsets, including Th1, Th2, Tr1, Th17 cells and a highly polyfunctional IL‐22‐producing T‐cell population. Cluster analysis highlighted that the IL‐22‐producing T‐cell population should be considered independently from the Th17 and Th1 subsets, although it was more closely related to the former. In parallel, we observed extensive TCRαβ sharing across all five subsets defined. The strategy described here allows the objective definition of cellular subsets and an unbiased insight into their similarities. Together, our results underscore the ontogenic plasticity of CD4+ T‐cell progenitors, which can adopt a differentiation profile irrespective of antigen specificity.
Anthradithiophene Derivatives Substituted at the 2,8‐Positions by Formyl and Triphenylamine Units: Synthesis, Optical, and Electrochemical Properties (Eur. J. Org. Chem. 17/2011)
Authors: Balandier Jean‐Yves , Sebaihi Noham , Boudard Pol , Lemaur Vincent , Quist Florence , Niebel Claude , Stas Sara , Tylleman Benoît , Lazzaroni Roberto , Cornil Jérôme , Geerts Yves Henri 
Published: June 2011

AbstractThe cover picture shows the comparison of the color of two anthradithiophene (ADT) derivatives bearing triphenylamine and formyl units with that of their parent ADT system in the solid state and in solution. This research was performed by a Belgian collaboration between the Université Libre de Bruxelles and the Université de Mons. This cooperation is highlighted by the well‐known monuments of both cities: the atomium of Brussels and the belfry of Mons. Details are discussed in the article by Y. H. Geerts et al. on p. 3131 ff.
Solid‐state fermentation of lignocellulotic materials for the production of enzymes by the white‐rot fungus Trametes hirsuta in a modular bioreactor
Authors: Böhmer Ulrike , Frömmel Susanne , Bley Thomas , Müller Matthias , Frankenfeld Katrin , Miethe Peter 
Published: June 2011

AbstractTrametes hirsuta, a filamentous basidiomycete, was successfully cultivated in solid‐state fermentation (SSF) on a mixture of pine wood chips and orange peel in a novel bioreactor that allows mixing of the inoculated solid material during the fermentation. Copper sulfate or xylidine (2,5‐dimethylaniline) were added to enhance the production of enzymes, especially laccases. For comparison, Trametes hirsuta was also cultivated in submerged conditions. The effect of additives in SSF was low, whereas the choice of the solid material and the rotation of the reactor vessel showed a significant influence on the enzyme production. The space‐time yields for the fermentations were calculated and showed that SSF on low‐cost substrates can effectively produce extracellular enzymes at a sufficient rate by a cultivation method that requires only low technology equipment.
Lovastatin and (+)‐geodin formation by Aspergillus terreus ATCC 20542 in a batch culture with the simultaneous use of lactose and glycerol as carbon sources
Authors: Bizukojc Marcin , Pecyna Marta 
Published: June 2011

AbstractThe influence of initial glycerol and lactose concentrations on lovastatin and (+)‐geodin formation in batch cultures of Aspergillus terreus ATCC 20542 was presented. At first the experiments comprised lovastatin biosynthesis on glycerol as the sole carbon source. Lovastatin titers below 40 mg/L were found under these conditions and they were lower than previously obtained results when lactose was used as the sole carbon source. However, the application of the mixture of glycerol and lactose allowed in achieving higher lovastatin concentration in the broth. It even exceeded 122 mg/L when 10 g lactose and 15 g glycerol per liter were used. The calculated lovastatin volumetric and specific formation rates on glycerol or lactose and on the mixture of these two showed that lovastatin was faster produced on lactose than on glycerol. In the trophophase, the maximum volumetric lovastatin formation rate on lactose was up to four times higher than on glycerol and so was the lovastatin specific formation rate. Similar relations for the accompanying (+)‐geodin biosynthesis were also studied. When the mixture of lactose and glycerol was used, the transformation of (+)‐geodin to other polyketide metabolites also took place.
A multi‐century record of linked nearshore and coastal change
Authors: Thomas T. , Phillips M. R. , Williams A. T. , Jenkins R. E. 
Published: June 2011

ABSTRACTUsing geographic information system (GIS) and field measurements the nearshore morphological variability of a headland bay beach at Tenby, West Wales (51·66 N; –4·71 W) was assessed over historical timeframes (1748–2007). Three areas chosen for detailed analysis were the area between mean low water (MLW) and lowest astronomical tide (LAT) contours; LAT and one fathom contours; and one and two fathom contours. Estuary closurec. 1855 has been suggested as the genesis for long‐term beach evolution and did have an initial effect, with northward dune migration and reduced flushing effects. However, this research suggests nearshore bank migration and retrogradation associated with spit collapse took place prior to closure and continued throughout the assessed timeframe. Historical data revealed patterns of shoreward migration demonstrated by changes in orientation, Giltar headland acting as a pivot. Variations in sandbank position correlated with areal reduction of both Giltar spit and White Bank. Temporal offshore areal loss was contrasted against variable gains inshore as offshore banks welded to the beachface. Annual volumetric change analyses represented by profiles that extend 1 km offshore, confirmed Giltar spit and White Bank erosion rates of 91 m3 yr–1and 458 m3 yr–1respectively, and 220 m3 yr–1beachface accretion. Diminution of sediment supply observed over historical timescales was supported by decadal evidence. Here, profile analysis revealed a trend of decreasing volumes both updrift and within the study area, and increasing downdrift volumes. This explained why proximal detachment and sediment redistribution had occurred. Distinct reversal's in shoreline trend (rotation) corresponded to nearshore change; therefore, variations in seabed configuration triggered shoreface dynamic change over century timescales. Five‐year cumulative average changes in North Atlantic Oscillation were further correlated to this reversal. As comparable scenarios are likely to exist at other worldwide coastal locations, similar analyses should be incorporated into shoreline monitoring programmes. Consequently, these assessments would inform shoreline trends and support coastal management decisions. Copyright © 2011 John Wiley & Sons, Ltd.
Investigation of three‐dimensional wind flow behaviour over coastal dune morphology under offshore winds using computational fluid dynamics (CFD) and ultrasonic anemometry
Authors: Jackson D. W. T. , Beyers J. H. M. , Lynch K. , Cooper J. A. G. , Baas A. C. W. , Delgado‐Fernandez I. 
Published: June 2011

ABSTRACTThe behaviour of offshore‐directed winds over coastal dune and beach morphology was examined using a combination of modelling (3‐D computational fluid dynamics (CFD)) and field measurement. Both model simulations and field measurements showed reversal of offshore flows at the back beach and creation of an onshore sediment transport potential. The influence of flow reversals on the beach‐dune transport system and foredune growth patterns has previously received little attention. Detailed wind flow measurements were made using an extensive array of mast‐mounted, 3‐D ultrasonic anemometers (50 Hz), arranged parallel to the dominant incident wind direction. Large eddy simulation (LES) of the offshore wind flow over the dune was conducted using the open‐source CFD tool openFOAM. The computational domain included a terrain model obtained by airborne LiDAR and detailed ground DGPS measurements. The computational grid (~22 million cells) included localized mesh refinement near the complex foredune terrain to capture finer details of the dune morphology that might affect wind flows on the adjacent beach.Measured and simulated wind flow are presented and discussed. The CFD simulations offer new insights into the flow mechanics associated with offshore winds and how the terrain steering of wind flow impacts on the geomorphological behaviour of the dune system. Simulation of 3‐D wind flows over complex terrain such as dune systems, presents a valuable new tool for geomorphological research, as it enables new insights into the relationship between the wind field and the underlying topography. The results show that offshore and obliquely offshore winds result in flow reversal and onshore directed winds at distances of up to 20 m from the embryo dune toe. The potential geomorphological significance of the findings are discussed and simple calculations show that incoming offshore and obliquely offshore winds with mean velocities over 13 m s−1 and 7 m s−1, respectively, have the potential to create onshore‐directed winds at the back beach with mean velocities above 3.3 m s−1. These are above the threshold of movement for dry sand and support previous conclusions about the significance of offshore winds in dune and beach budget calculations. Copyright © 2011 John Wiley & Sons, Ltd.
A comparative study of range‐based stock return volatility estimators for the German market
Authors: Todorova Neda , Husmann Sven 
Published: June 2011

AbstractThis study investigates the relative performance of various volatility estimators based on daily and intraday price ranges of 25 German equities, with the two‐scales realized volatility used as a benchmark. The empirical results show that all estimators based on daily ranges are by far superior to the classical estimator but are severely negatively biased due to discrete trading. The realized range obtained from intraday ranges performs better in terms of both bias and efficiency, although its performance still suffers from discrete trading. In these settings, the bias correcting procedure developed by Christensen and Podolskij (2007) appears to consistently outperform all other alternatives, including the scaled version of Martens and van Dijk (2007), and provides evidence of the relative advantages of the realized range. © 2011 Wiley Periodicals, Inc. Jrl Fut Mark 32:560–586, 2012