bluuebunny/crossref_metadata_2025_split huggingface dataset:
Les coutumes de Lorris. Notes complémentaires sur leur contexte politique, leur date et leur contenu avec leur texte latin et sa traduction
Authors: Magnou-Nortier Élisabeth 
Published: February 2025

Alors que se profile la commémoration du neuvième centenaire de l’octroi des « coutumes » de Lorris, le présent article se propose de remettre en perspective les apports précieux des études menées à son sujet par Maurice Prou en 1884 et Augustin Fliche en 1912 au regard des renouvellements historiographiques des dernières décennies. La relecture des sources et du contexte politique permet de mieux saisir les circonstances dans lesquelles le roi Louis VI accorda par cette charte de nouvelles « libertés » aux habitants de ce village du Gâtinais. Dans le même temps, elle suggère une mise au point sur la nature des « privilèges et franchises » accordés et réévalue les différentes instances qui assumaient les responsabilités administratives et fiscales au niveau local, tout en apportant le faible éclairage que les sources laissent entrevoir sur le cadre de vie des villageois. En complément de l’étude, le texte latin original de la charte et une nouvelle traduction sont publiés en annexe.
Fulgence de Ruspe, l’aristocratie romano-africaine et le pouvoir vandale sous les règnes de Gunthamund et de Thrasamund : collaboration ou résistance ?
Authors: Pottier Bruno 
Published: February 2025

Deux modalités de résistance nicéenne face à l’arianisme défendu par les rois vandales à la fin du ve siècle et au début du vie siècle peuvent être discernées à travers la biographie hagiographique de l’évêque Fulgence de Ruspe, la création de monastères pour compenser la persécution du clergé catholique et la pratique de la polémique religieuse. Certains notables nicéens africains ont compensé leurs compromissions avec l’administration vandale arienne par la fuite du monde ou par le financement de monastères et la création de liens avec des moines charismatiques comme Fulgence. Les rois vandales n’ont en effet que rarement inquiété les monastères nicéens en concédant cet espace de liberté à une Église par ailleurs persécutée. Le débat que Thrasamund a organisé entre 517 et 519 à Carthage avec Fulgence, rappelé d’exil pour l’occasion, a marqué la volonté de ce roi de créer un nouveau modèle d’excellence pour les élites africaines et les membres de la cour vandale. Il supposait tant la maîtrise de la culture classique, notamment par la création poétique, que des compétences théologiques. Des lettres de Fulgence montrent le succès de cette politique qui a conduit à l’intégration de la théologie dans l’otium littéraire, notamment lors de banquets. Ceci permet de nuancer l’idée d’un très large ralliement des élites africaines à un secular space religieusement neutre, promu par les rois vandales, qui est souvent inféré à partir de l’étude des seuls poèmes de l’Anthologie latine. Cependant, Fulgence, qui est resté en général loyal envers les rois vandales, apparaît paradoxalement dans ce cadre comme leur allié objectif, puisqu’il a facilité par ses actions l’acceptation de leur régime par les élites nicéennes.
Antibiotic prescribing in public primary healthcare centres in Maseru, Lesotho
Authors: Letša Mapoloko A. , Burger Johanita R. , Kotzé Irma 
Published: February 2025

Background: Inappropriate prescribing of antibiotics is a global problem. We assessed the prescribing patterns of antibiotics in three public primary healthcare centres (PHCCs) in Maseru, Lesotho.Objectives: A cross-sectional point prevalence survey was employed using patients’ prescription booklets from October 2022 to December 2022.Method: Antibiotics were categorised according to the World Health Organization (WHO) AWaRe classification and assessed by Defined Daily Dose (DDD)/100 outpatients/day to measure relative consumption of each antibiotic as a percentage of total consumption, Access-to-Watch index (AW-I) and Amoxicillin Index (A-I).Results: Of the 624 participants (median age 35 [interquartile range {IQR}: 45–26] years), 71.5% (n = 446) were female. Overall mean (standard deviation [s.d.]) antibiotic consumption was 1.48 (0.13) DDD/100 outpatients/day, with PHCC-1 at 1.64, PHCC-2 at 1.33 and PHCC-3 at 1.47 DDD/100 outpatients/day. The median (IQR) AW-I was 4.64 (3.42–9.45) and the A-I was 1.41 (0.87–1.95). The most frequently prescribed Access group antibiotics included amoxicillin (PHCC-2: 45.9%, overall 1.33 DDD/100 outpatients/day; PHCC-3: 24.5%, 1.47 DDD/100 outpatients/day, and PHCC-1: 23.2%, 1.64 DDD/100 outpatients/day) and doxycycline (PHCC-3: 29.9%, 1.47 DDD/100 outpatients/day, 24.1%, PHCC-2: 1.33 DDD/100 outpatients/day). Erythromycin was the most prescribed Watch group antibiotic for all PHCCs.Conclusion: High consumption of Access-group antibiotics was observed. The Watch group’s antibiotic use, particularly erythromycin, requires the implementation of stewardship programmes. Results may be a baseline for establishing antibiotic stewardship in Lesotho’s PHCCs.Contribution: Our study addressed the scarcity of data on antibiotic prescribing patterns in PHCCs in Lesotho using the AWaRe classification system recommended for monitoring antibiotic prescribing and promoting rational use.
Comparison of Peri-Oral and Masticatory Muscle Activity between Repaired Unilateral Cleft Lip and Palate and Non-Cleft Individuals - A Systematic Review
Authors: Kakkar Saumya , Tripathi Tulika , Rai Priyank , Veena GV , Singh Deepak 
Published: February 2025

Abstract
Surgical intervention in patients with repaired unilateral cleft lip and palate (UCLP) leads to altered muscular activity and hinders the normal growth of the maxilla. To compare the activity of superior orbicularis oris and masticatory muscles between repaired unilateral cleft lip and palate and non-cleft individuals. A literature search was carried out on MEDLINE/PubMed, Cochrane Library, Science Direct, Semantic Scholar, and Google Scholar databases upto January 2024 resulting in 1320 studies. Specified inclusion/exclusion criteria guided the selection of five relevant articles. Study selection, assessment of the outcome of articles, and subsequent Risk of Bias (RoB) assessment were done independently by three authors. In case of any disparity, the fourth and fifth authors were consulted. All five studies were observational cross-sectional studies. The majority of the studies reported an altered muscular activity in repaired UCLP patients compared to normal individuals, which may affect the normal growth of the maxilla. Patients with repaired UCLP show an increased muscle activity compared to non-cleft subjects, which may lead to altered masticatory efficiency in such patients.
Evaluation of fat implantation in patients with sulcus vocalis: Acoustic assessment before and after treatment
Authors: Tandan Nisha , Pachaury Shuchita Singh , Kairo Arvind Kumar , Singh Chirom Amit , Mao Pallavi , Kumar Rakesh , Thakar Alok 
Published: February 2025

ABSTRACT

Objective:
Sulcus vocalis is the most difficult clinical entity to treat. This study aims to prospectively intervene and evaluate the efficacy of employing fat implantation for treating cases of sulcus vocalis, using acoustic assessment as the primary evaluation tool.

Materials and Methods:
Thirteen patients diagnosed with sulcus vocalis II/III, who were refractory to over 6 months of speech therapy were enrolled in the study. The surgical intervention involved harvesting fat through a periumbilical incision, followed by its implantation into the vocal fold after creating a submucosal pocket and securing it with tissue glue. The patients were assessed at 1 and 3 months post-surgery.

Results:
The results revealed that subjective improvements were observed in patients with sulcus vocalis using the Voice Handicap Index, with statistically significant improvements at 1 (P = 0.017) and 3 months (P < 0.001), whereas perceptual parameters, such as the grade, roughness, breathiness, asthenia, strain scale, did not show significant effects. Voice analysis demonstrated improvements in maximum phonation time (P = 0.022 at 3 months), S/Z ratio (P = 0.009 at 3 months), jitter (P = 0.012 at 3 months), shimmer (P = 0.050 at 3 months), and noise-to-harmonics ratio (P = 0.016 at 3 months) over time. However, no significant changes were noted in fundamental frequency (f0) and (VAM), loudness range, and pitch range at both time points.

Conclusions:
This study concludes that fat implantation appears to be a promising treatment option for refractory cases of sulcus vocalis. This pilot study demonstrated subjective improvements in some acoustic parameters over time. The limitations of this study, being its small sample size and fat implantation done on a single vocal cord, underscore the need for further research to comprehensively evaluate the safety, efficacy, patient selection criteria, and long-term outcomes of fat implantation for sulcus vocalis.
The impact of remote working on sleep quality in otolaryngology
Authors: Mowat Andrew , Ang Trisha , Sturges Pamela , Jervis Suzanne 
Published: February 2025

ABSTRACT

Background:
Shift work can lead to sleep deprivation and circadian misalignment. Sleep disturbances have implications for patient care, clinician well-being, and overall healthcare performance. In the United Kingdom, otolaryngology operates a non-resident on-call structure at registrar and consultant levels, necessitating availability for remote consultation and potential on-site attendance overnight.

Objectives:
Whilst resident on-call rotas have been shown to have a detrimental effect on sleep quality, the impact of non-resident on calls remains under investigated. This study aims to assess the impact of non-resident on-call structures on sleep quality using smart phone sleep-tracking.

Materials and Methods:
Three consultants and three registrars monitored their sleep quality using the mobile phone application ‘Sleep cycle’ over a ten week on call cycle at a district general hospital. Data was collected prospectively and results analysed anonymously.

Results:
Sleep length was longest during off days (when clinicians had no clinical commitments the following day). The average sleep length for consultants was 7.07 h versus 6.97 h for registrars. There were variations in sleep quality across different work and on-call scenarios. For consultants, the highest average sleep quality was during on-call hours (80.00%). Sleep quality was lowest when a consultant was called for advice after 22:00h (54.00%), however, this increased to 73.00% when a consultant was required on site after 22:00 h. For registrars, average sleep quality was highest during off days at 83.00%. When registrars were contacted for advice overnight, average sleep quality was 68.67% and was lowest when registrars were called on-site after 22:00h (57%).

Conclusion:
Sleep length and quality are negatively affected by non-resident on-calls when clinicians are contacted after 22:00h. There is no measurable impact on sleep quality when clinicians are not disturbed whilst on-call remotely. NHS trusts should monitor the wellbeing of their doctors and consider the implications of overnight commitments when structuring elective rotas.
Lyme disease: a comprehensive perspective on pathogen biology, clinical aspects and epidemiology in India
Authors: Sarath Pulamoola Kelu , Aneesh Embalil Mathachan 
Published: February 2025

Background & objectives:
Lyme disease is a multisystem illness caused by the spirochaetes bacteria belonging to the genus Borrelia. It’s a tick-borne disease that poses serious health concerns in major parts of the world including India. This review aims to comprehend the disease in depth encompassing its pathogen biology, clinical presentations, diagnosis, treatment strategies, epidemiology in India, and preventive measures against it.

Methods:
Peer-reviewed articles, reviews, meta-analyses and clinical studies relating to the topic were searched across reliable electronic databases like PubMed, and ScienceDirect, without imposing any time restriction for up-to-date information with a focus on sources indexed in the Science Citation Index (SCI).

Results:
The pathogen is a gram-negative bacterium namely Borrelia burgdorferri infesting ticks mainly belonging to the genus Ixodes. Clinical presentations vary from single Erethema Chronicum Migrans (ECM) to neurological complexities, cardiac disorders, and severe arthritic conditions. A two-tiered test recommended by CDC is currently employed to diagnose the disease. 15 out of 28 states in India have reports of Lyme disease; most of these states also have Ixodes ticks. However, the exact vector is not confirmed in India.

Interpretation & conclusion:
13 of the 15 states where Lyme disease cases have been reported have also had ticks belonging to the genus Ixodes. Thus it can be assumed that vectors of Lyme disease in India are Ixodes sp., but more studies are required to confirm and validate this assumption, and find the exact species of the vector tick. As an ignored vector-borne disease in India, Lyme disease warrants more research and surveillance.
Immunoinformatic based multi-epitope vaccine design and validation against Kyasanur forest disease: A tick borne viral infection
Authors: Adla Deepthi , Josyula Jhansi Venkata Nagamani , Ancha Tejaswini , Mutheneni Srinivasa Rao 
Published: February 2025

Background & objectives:
Kyasanur Forest Disease (KFD) is a tick-borne viral illness prevalent in the Western Ghats region of India, posing a significant public health concern. The current formalin-inactivated KFDV vaccine exhibits modest efficacy, necessitating the development of more potent preventive measures.

Methods:
This study employed immunoinformatic modelling techniques to design a multiepitope-based vaccine subunit targeting humoral and cell-mediated immune responses against KFDV. The vaccine was constructed using helper T cell (CD4+), cytotoxic T cell (CD8+), and B cell epitopes, linked together with appropriate linkers and an adjuvant β-defensin at the N-terminus, resulting in a 704 amino acid long vaccine subunit. Evaluation parameters included immunogenic potency, allergenicity, solubility, toxicity, and population coverage. Predictions of secondary and three-dimensional (3D) structure were made, followed by docking studies with Toll-like receptor-3 (TLR3) and major histocompatibility complex (MHC-I and II) to assess binding affinity. Additionally, simulation of the vaccine and TLR3 construct was performed using the iMod server to further analyze their interaction dynamics.

Results:
The developed vaccine subunit exhibited favorable structural and dynamic stability, with strong binding affinity to target receptors. Codon optimization and in silico cloning analysis indicated high vaccine expression and potency. Immune stimulation studies revealed enhanced production of IgG, IgM, helper T cells, cytotoxic T cells, INF-gamma, and IL-2, indicative of robust immune response against KFDV.

Interpretation & conclusion:
The developed vaccine construct was structurally and dynamically stable and produced a strong immune response against KFDV. However, further animal model studies are needed to assess the efficacy and safety of these vaccines for the prevention of KFDV. The vaccine subunit structure was submitted to the ModelArchive database (https://www.modelarchive.org/doi/10.5452/ma-ij19q).
The Glass Cliff and Burnout: The Mediating Role of Self-Confidence Among Women in the Tunisian Public Sector
Authors: Achour Zyed 
Published: February 2025

This study examines the relationship between the glass cliff phenomenon, burnout, and self-confidence among female leaders in the Tunisian civil service. Using a quantitative methodology, we surveyed 66 female leaders who experienced glass cliff situations, employing validated scales for glass cliff experiences, burnout, and self-confidence. Data analysis, conducted using Hayes' PROCESS module and ANOVA, reveals a positive association between glass cliff experiences and burnout symptoms (total effect coefficient = 0.29, p < 0.05), with self-confidence partially mediating this relationship (indirect effect = -0.12). Glass cliff experiences directly decrease self-confidence (coefficient = -0.35), which in turn influences burnout (coefficient = -0.30). Job tenure moderates these relationships, with less experienced leaders reporting higher stress and burnout levels. This study contributes to understanding gender dynamics in leadership within Arab and Mediterranean public sectors, being among the first to empirically examine these variables in this cultural context. Our findings highlight the need for targeted support mechanisms, including mentoring programs and confidence-building initiatives, to promote the well-being and success of women leaders in the Tunisian public sector. Limitations include the relatively small sample size, potentially affecting generalizability. This research offers practical insights for policymakers and public service managers to address gender-specific leadership challenges while extending theoretical understanding of the glass cliff phenomenon in diverse cultural settings.

Received: 14 September 2024 | Revised: 29 October 2024 | Accepted: 23 January 2025

Conflicts of Interest
The author declares that he has no conflicts of interest to this work.

Data Availability Statement
The data that support this work are available upon reasonable request to the corresponding author.

Author Contribution Statement
Zyed Achour: Conceptualization, Methodology, Validation, Formal analysis, Investigation, Data curation, Writing - original draft, Writing - review & editing, Visualization, Supervision, Project administration.
PERKEMBANGAN INDUSTRI E-SPORT DAN PENGARUHNYA TERHADAP PERTUMBUHAN EKONOMI DI PEMATANG SIANTAR
Authors: Romario F D Purba  , Rafael E J Siregar  , Pawer D Panjaitan  , Darwin Damanik  , Ade Nurul Elisyah  , Ade Nurma Dani  , Rizky Sahertian  
Published: February 2025

E-sports is one of the techno-based sports that is generally held in the form of a video game tournament between several players which also has a fan base of millions of people. E-sports has values in the form of sports, economic, social, achievement, and knowledge values like sports in general. The parent organization of E-sport Indonesia itself is the Indonesian E-sport Executive Board (PBESI) chaired by Prof. Dr. Budi Gunawan, S.H., Si. This research aims to find out how the development of E-sport and what impact it has on economic growth in Pematangsiantar City.
FORMULATION AND PHYSICAL EVALUATION OF KARAMUNTING FLOWER EXTRACT SHOOTING PREPARATION (Melastoma malabathricum L.)
Authors: Citrariana Shesanthi , Febrianto Yahya , Rahman Sudarman , Fatiqin Awalul , Suprayogi Thatit , Alfanaar Rokiy , Arsana Mu’afa Purwa 
Published: February 2025

Soothing gel is a new cosmetic preparation in society with physical properties that increase the acceptability and effectiveness of therapy. Karamunting (Melastoma malabatricum L.) is a plant that is widely known in the Central Kalimantan region. Karamunting flowers contain flavonoid, alkaloid and saponin. The flavonoid in karamunting can be used as antioxidants. The aim of this research is to formulate karamunting flower extract (Melastoma malabathricum L.) as a soothing gel and evaluate the physical properties. The formulation method used variations of carbopol and HPMC with an extract concentration of 5%. Phytochemical testing of the extract was carried out using a tube test and total flavonoid using UV-Vis. The physical properties of the gel were tested in the form of organoleptic, homogeneity, viscosity and adhesion tests. The total flavonoid yield of karamunting flower extract was 21.22% w/w. Organoleptic properties: odorless aroma, brownish red color, and cool sensation on the skin. The preparation is homogeneous and has a viscosity of 200-300 dpa's and an adhesive force of 10.50-21.24 seconds. So it can be concluded that shooting gel karamunting flower extract has good physical properties.
ANALISIS PENDAPATAN USAHA PENETASAN TELUR ITIK DIDESA MAMAR KECAMATAN AMUNTAI SELATAN KABUPATEN HULU SUNGAI
Authors: Juwita Juwita , Yamani Ahmad Zaki , Masliani Masliani , Ludang Ellydia 
Published: February 2025

Hasil penelitian menunjukan bahwa deskripsi dari usaha penetasan telur itik ialah usaha penetasan telur itik yang menghasilkan dua jenis bibit itik yang di dihasilkan yakni bibit itik mojosari alabio dan bibit itik peking dengan lama proses penetasan telur itik ini dalam satu kali produksi membutuhkan waktu selama 28 hari menggunakan mesin penetas listrik. fertilitas itik mojosari alabio yaitu 93,83% dengan daya tetas 80,03% sedangkan fertilitas itik peking yaitu 89,86% dengan daya tetas 79,80%, berarti fertilitas dan daya tetas itik mojosari alabio lebih bagus dibandingkan dengan fertilitas dan daya tetas itik peking. Untuk analisis pendapatan dilakukan dari penerimaan, total biaya, serta pendapatan. Penerimaan yang di peroleh per periode adalah Rp 20.581.048 dengan total biaya yang terdiri dari biaya tetap dan biaya variabel adalah Rp 8.787.776 sehingga pendapatan yang di peroleh adalah Rp 11.793.271,83 per periode. Untuk menjawab tujuan ketiga, menggunakan analisis R/C Ratio sehingga di peroleh per periodenya adalah 2,34. Jika nilai R/C Ratio > 1 maka usaha penetasan telur itik yang dilakukan oleh peternak Desa Mamar dianggap layak untuk di usahakan.
REPRODUÇÃO ASSISTIDA POST MORTEM: UMA ANÁLISE SOBRE OS EFEITOS SUCESSÓRIOS
Authors: Trindade Diego Abe , Bonini Luci M. M. , Oliveira Maria Isabel C. G. A. de 
Published: February 2025

Esse artigo tem como objetivo: compreender quais são os efeitos da reprodução assistida post mortem no direito das sucessões. Como método, buscou-se a revisão da legislação, da doutrina e da jurisprudência, resoluções do Conselho Federal de Medicina e a Carta Magna, procurando, assim, ampliar os diferentes posicionamentos relacionados ao tema. A reprodução assistida é reconhecida como um direito à saúde pela Constituição Federal, que enfatiza que a saúde é um direito universal e uma responsabilidade do Estado. Essa proteção constitucional destaca as complexidades que cercam a dinâmica familiar e os desafios enfrentados por indivíduos que buscam conceber por meio da reprodução assistida. Além disso, a Provisão nº 63 de 14 de novembro de 2017 facilita o registro de nascimentos e o reconhecimento da parentalidade socioafetiva para crianças concebidas por meio da reprodução assistida, ao mesmo tempo em que defende a autorização da reprodução assistida post-mortem usando material biológico preservado, garantindo que os desejos dos indivíduos sejam respeitados e protegidos. Concluiu-se que para as questões sucessórias diante da reprodução assistida post mortem, enquanto não temos regulamentação ampla em sentido jurídico, podemos enfatizar que é necessária a manifestação do desejo da vontade daquele que se foi, o testamento, que se trata de um documento de grande celeridade até o presente momento, que autoriza a sucessão de bens, o reconhecimento de paternidade, entre outras situações, ou seja, podendo assim surgir, futuramente algum documento que o substitua para essa finalidade específica, sobre o tema aqui debatido.
Enkele aspecten van bemiddeling in conflicten met een multiculturele component
Authors: Dubois Marco 
Published: February 2025

Some aspects of mediation in conflicts with a pluralistic component
In this contribution some aspects of the pluralistic society and its impact on mediation are discussed. For that purpose, first the focus is in on what is generally understood by ‘culture’ and ‘conflict’, followed by a description of communication problems that might arise in (mediation)situations with a particular cultural dimension. Next the question is posed to what extent a mediator should be susceptible for cultural dimensions in conflicts to perform his job well. And if he is prepared to do so, what pitfalls and challenges he should be prepared for?