bluuebunny/crossref_metadata_2025_split huggingface dataset:
ORIGINAL ARTICLE: Argyrophilic grain disease with delusions and hallucinations: a pathological study
Authors: ASAOKA Toshiyasu , TSUCHIYA Kuniaki , FUJISHIRO Hiroshige , ARAI Tetsuaki , HASEGAWA Masato , AKIYAMA Haruhiko , ISEKI Eizo , ODA Tatsuro , ONAYA Mitsumoto , TOMINAGA Itaru 
Published: September 2010

AbstractNo clear clinical syndrome for argyrophilic grain disease (AGD) has yet been identified. Previous studies have documented its clinical features, namely, personality changes characterized by emotional disorder involving aggression or ill temper and relatively well‐preserved cognitive function, but the clinical manifestations of delusions and hallucinations as they appear in AGD have not been thoroughly described. Here, we report on a 72‐year‐old Japanese AGD patient who showed psychiatric symptoms, memory impairment and emotional change. He perceived and described a person who was not present and tried to grasp things on the floor though nothing was there. He also insisted that somebody was watching him and consequently always kept his curtains closed. These psychiatric symptoms were observed at an early stage in the patient's disease course. Serial neuroradiological examination showed progressive atrophy of the bilateral temporal lobes. The patient died at 79 years‐of‐age. Microscopic neuropathological examination showed transactivation responsive region (TAR)‐DNA‐binding protein of 43 kDa (TDP‐43) positive structures in addition to widespread argyrophilic grains and coiled bodies. According to recent recommendations for pathological diagnosis, this case corresponds to AGD with limbic TDP‐43 pathology. This case shows that patients with AGD that is eventually confirmed through autopsy can present with delusions and hallucinations early in the course of their disease. The clinical significance of TDP‐43 pathology in the brains of patients with AGD remains uncertain.
Protein C and/or Protein S Deficiency and Occurrence of Stent Thrombosis: A Hitherto Unrecognized Association
Authors: GOEL PRAVIN K. , BATRA ADITYA 
Published: September 2010

Objective: To study the prevalence of protein C and/or protein S deficiency in patients of stent thrombosis and correlate its association with the event, if any.
Background: Stent thrombosis is the Achilles heel of percutaneous coronary intervention (PCI) and has been associated with so many predisposing factors that if one analyzes all patients undergoing PCI, one or more such factors would be present in almost every patient; however, its incidence remains no more than 1–2%. We hypothesized a preexisting prothrombotic state, or tendency, in a small proportion of patients that possibly plays a key role in its occurrence.
Methods: We analyzed the prothrombotic tendency of individual patients by studying protein C and protein S levels. Thirteen patients presenting with stent thrombosis and 24 age‐ and sex‐matched controls were studied.
Results: Protein S was found to be deficient in 11 of 13 patients (84.6%) of stent thrombosis and in only 4 of 24 patients (16.7%) in matched controls (P < 0.001), while protein C was found deficient in 2 of 12 patients (16.7%) of stent thrombosis, and 1 of 24 patients (4.2%) in matched controls (P = 0.25) and either protein C or protein S was deficient in 11 of 13 (84.6%) of stent thrombosis and 5 of 24 (20.8%) controls (P = <0.001). Low protein S levels were strongly associated with stent thrombosis (odds ratio 3.04, 95% confidence interval 1.34–4.7) with sensitivity 0.73 and specificity of 0.91.
Conclusions: Protein S deficiency is strongly correlated to the occurrence of stent thrombosis, a fact that has hitherto not been recognized and needs further evaluation. (J Interven Cardiol 2010;23:560–564)
Identity Discourses on the Dancefloor
Authors: RILL BRYAN 
Published: September 2010

ABSTRACTElectronic Dance Music Culture (EDMC) is one of the largest subcultural musical movements in history. The dance floor is a creative context that engenders a freedom among participants to reshape their social identity within the Temporary Autonomous Zones (TAZ) that raves, the central spaces for EDMC, provide. On the dance floor, participants enter into powerful trances that have the capacity to reshape notions of self and personhood. This paper examines such identity discourses and suggests that trance consciousness re‐constitutes the bodily self as an interaction rather than a corporeal body, radically altering the internal dialogue from which notions of self originate. I illuminate this process by articulating the phenomenal experience of musical trancing with scientific theories of human consciousness. Drawing on the ideas of Merleau‐Ponty and Damasio, I suggest an integrative model of consciousness that sheds new light upon the complex layering of trance experiences. The potential benefit of this model lies in its ability to theoretically capture the ineffable musical experience and reveal salient processes underlying the self‐transformation reported in subjective narratives. This is pertinent not only to EDMC and other musical cultures, but to our more general understanding of the relationship between self and experience in the world.
On the Potential Use of Cup‐Marks
Authors: GOSSO FULVIO 
Published: September 2010

ABSTRACTThe author, starting from what is currently known about cup‐marks and their distribution in the north‐western Italian alpine area, formulated a hypothesis on their material and ritual functions in the Neolithic period. It is conceivable that cup‐marks were originally carved in connection with the ritual use of Amanita muscaria, and that they may later have assumed other functions as well.
Will only an earthquake shake up economics?
Authors: SCHETTKAT Ronald 
Published: September 2010

Abstract.“Natural rate theory”, the Efficient Market Hypothesis and its labour market application dominated interpretations of economic trends and policy prescriptions from the 1970s onwards, with their views of public policy and regulation as distorting otherwise well‐functioning free markets. The upheaval of the current crisis is shaking these theories to the core. In this context, Schettkat examines European experience from the 1990s onwards and shows the theories to be unsubstantiated: high unemployment persisted post‐recession despite structural reforms to labour market institutions, and the resumption of economic growth was hindered by then‐dominant deflationary monetary and fiscal policies inspired by these theories.
¿Hará falta un terremoto para que despierte la teoría económica?
Authors: SCHETTKAT Ronald 
Published: September 2010

Resumen.La teoría de la tasa «natural» de desempleo y la hipótesis del mercado eficiente vienen dominando desde los años setenta delsiglopasado las interpretaciones de las tendencias económicas y las recetas programáticas. La idea maestra es que la acción de los gobiernos y las leyes distorsiona unos mercados libres que, sin estas trabas, funcionarían bien. La crisis actual es como un terremoto que está sacudiendo las bases de estas teorías. El autor demuestra que carecen de fundamento, ya que, una vez superadas las recesiones, y pese a las reformas estructurales implantadas en los mercados laborales europeos, no se recuperó bien el empleo y las políticas monetarias, presupuestarias y fiscales deflacionarias coartaron el crecimiento económico.
The Potential for Ground Water Contamination by the Gasoline Lead Scavengers Ethylene Dibromide and 1,2‐Dichloroethane
Authors: Falta Ronald W. 
Published: September 2010

AbstractEthylene dibromide (EDB) is a synthetic organic chemical that was produced in large amounts for use as a leaded gasoline additive and pesticide. The chlorinated solvent 1,2‐dichlorethane (1,2‐DCA) is widely used in the chemical industry, and was also added to leaded gasoline. EDB and 1,2‐DCA are classified as probable human carcinogens by the U.S. Environmental Protection Agency (U.S. EPA), and EDB's use as a pesticide was suspended in 1984. The current U.S. EPA maximum contaminant level (MCL) for EDB in drinking water is 0.05 μg/L, and the MCL for 1,2‐DCA is 5 μg/L. EDB has proven to be both mobile and persistent in ground water, and contamination of ground water by EDB was documented in several states beginning in the early 1980s. The majority of this contamination is attributed to agricultural uses of EDB; however, ∼90% of the EDB produced was used as a leaded gasoline additive and it was present in virtually all leaded gasoline sold in the United States. 1,2‐DCA is commonly found as a ground water contaminant, and it is both mobile and persistent. Past investigations and remediation efforts at sites contaminated by leaded gasoline have rarely addressed the potential for EDB or 1,2‐DCA contamination. For this reason, there is a substantial likelihood that undetected EDB and 1,2‐DCA plumes above the MCL may exist at many sites where leaded gasoline leaked or spilled.
Bioengineering of a Nisin A‐producing Lactococcus lactis to create isogenic strains producing the natural variants Nisin F, Q and Z
Authors: Piper Clare , Hill Colin , Cotter Paul D. , Ross R. Paul 
Published: September 2010

SummaryNisin is the prototypical example of the lantibiotic family of antimicrobial peptides and has been employed as a food preservative for over half a century. It has also attracted attention due to its potency against a number of multidrug‐resistant clinical pathogens. Nisin A is the originally isolated form of Nisin and a further five natural variants have been described which differ by up to 10 amino acids (of 34 in total in Nisin A). Nisins A, Z, F and Q are produced by Lactococcus lactis, while Nisins U and U2 are produced by Streptococcus sp. In this study we bioengineered the nisA gene of a Nisin A producer to generate genes encoding Nisins Z, F, Q, U and U2. We determined that while active Nisin Z, F and Q can be produced against this genetic background, active forms of Nisin U and U2 are not generated. Minimum inhibitory concentration studies with Nisin A, Z, F and Q variants against a series of different clinically significant pathogens establish differences in specific activities against selected targets. Nisin F was most impressive, being the most active, or one of the most active, against the MRSA strain ST 525, EC 676, EC 725, VISA 22900, VISA 22781, hVISA 35197, Staphylococcus aureus 8325‐4 and L. lactis HP. Nisin Z was most active against ST 299, hVISA 32683 and, together with Nisin F, HP but had contrastingly poor activity against ST 525, EC 676 and 8325‐4. Nisin F, Q and A exhibited similar potency against VISA 22900. This was the only target against which Nisin Q and Nisin A were among the most active variants.
Evidence for the effects of environmental engagement and education on knowledge of wildlife laws in Madagascar
Authors: Keane Aidan , Ramarolahy Andriamahatsiaro A. , Jones Julia P.G. , Milner‐Gulland E.J. 
Published: September 2010

AbstractRules are fundamental to the implementation of conservation policies, but cannot change behavior if they are not known or understood. Despite this, few studies have investigated knowledge of conservation rules or factors influencing it. Here, we quantify the effects of involvement with tourism and community‐based natural resource management, education and demographic factors on local people's awareness of Madagascar's species protection laws. Knowledge of the laws was generally low. However, those who worked as tourist guides, hosted tourists, and were involved in local forest management committees were almost twice as likely to classify correctly a species as protected compared with individuals not exposed to conservation messages in this way. This year marks 50 years since Madagascar introduced its first species protection law. It is time to recognize that rules are necessary, but not sufficient, for species protection and to devote more attention to the communication, and enforcement, of conservation rules.
Jurassic Amber in Lebanon
Authors: AZAR Dany , GÈZE Raymond , EL‐SAMRANI Antoine , MAALOULY Jacqueline , NEL André 
Published: September 2010

Abstract:Reports of amber predating the Lower Cretaceous are unusual and scarce; they mostly refer to amber pieces of millimetric dimension. In the present study, we report the discovery of 10 new outcrops of Jurassic amber in Lebanon. Some of these had large centimetric‐sized pieces of amber. The new localities are described, amber is characterized, and its infrared spectra given. Although the new Jurassic amber yielded to date no more than fungal inclusions, this material is significant and promising. The discovery of several Jurassic outcrops provides crucial information on the prevailing paleoenvironment of that time.
A New Family of Moths from the Middle Jurassic (Insecta: Lepidoptera)
Authors: Diying HUANG , NEL André , MINET Joël 
Published: September 2010

Abstract:Three lepidopteran species, from the Middle Jurassic Daohugou beds (inner Mongolia, China), are described in a new family, Mesokristenseniidae, and new genus, Mesokristensenia, which could represent the sister group of the Micropterigidae. Mesokristensenia differs from all extant Lepidoptera, but one genus (Agathiphaga, Agathiphagidae), in retaining four median veins in the forewing, a plesiomorphy also present in many Trichoptera. Evidence for placing Mesokristensenia in the Lepidoptera includes four traits, notably a previously unrecorded autapomorphy of this insect order: beyond stem M1+2, vein M1 is bent and connected to cross‐vein r‐m (in both wing pairs). Among 24 characters taken into account to assess the systematic position of Mesokristensenia, 12 are considered informative for a cladistic analysis involving this fossil taxon and the four suborders recognized in present‐day Lepidoptera (Zeugloptera, Aglossata, Heterobathmiina, and Glossata).
A New Thorny Lacewing (Insecta: Neuroptera: Rhachiberothidae) from the Early Cretaceous Amber of Lebanon
Authors: PETRULEVIČIUS Julian F. , AZAR Dany , NEL André 
Published: September 2010

Abstract:A new genus and species of Rhachiberothidae, Raptorapax terribilissima gen. et sp. nov. from the Cretaceous amber of Lebanon is described. The new genus is assigned to the subfamily Paraberothinae. The new material confirms the great diversity of the group in the Cretaceous age and its decrease in diversity in recent times.
The Chemokine Receptor CXCR2 Ligand KC (CXCL1) Mediates Neutrophil Recruitment and Is Critical for Development of Experimental Lyme Arthritis and Carditis
Authors: Ritzman Anna M. , Hughes-Hanks Jennifer M. , Blaho Victoria A. , Wax Laura E. , Mitchell William J. , Brown Charles R. 
Published: September 2010

ABSTRACTDeletion of the chemokine receptor CXCR2 prevents the recruitment of neutrophils into tissues and subsequent development of experimental Lyme arthritis. Following footpad inoculation ofBorrelia burgdorferi, the agent of Lyme disease, expression of the CXCR2 ligand KC (CXCL1) is highly upregulated in the joints of arthritis-susceptible mice and is likely to play an important role in the recruitment of neutrophils to the site of infection. To test this hypothesis, we infected C3H KC−/−mice withB. burgdorferiand followed the development of arthritis and carditis. Ankle swelling was significantly attenuated during the peak of arthritis in the KC−/−mice. Arthritis severity scores were significantly lower in the KC−/−mice on days 11 and 21 postinfection, with fewer neutrophils present in the inflammatory lesions. Cardiac lesions were also significantly decreased in KC−/−mice at day 21 postinfection. There were, however, no differences between C3H wild-type and KC−/−mice in spirochete clearance from tissues. Two other CXCR2 ligands, LIX (CXCL5) and MIP-2 (CXCL2), were not increased to compensate for the loss of KC, and the production of several innate cytokines was unaltered. These results demonstrate that KC plays a critical nonredundant role in the development of experimental Lyme arthritis and carditis via CXCR2-mediated recruitment of neutrophils into the site of infection.
Portal inflammation is associated with advanced histological changes in alcoholic and non-alcoholic fatty liver disease
Authors: Rakha Emad A , Adamson Louise , Bell Emily , Neal Keith , Ryder Stephen D , Kaye Philip V , Aithal Guruprasad P 
Published: September 2010

BackgroundFatty liver disease (FLD), of either alcoholic (AFLD) or non-alcoholic (NAFLD) aetiologies, is characterised histologically by features that are lobulocentric that typically affect zone 3, in contrast with portal-based inflammation characteristics of other forms of chronic liver disease.AimThe authors aimed to determine the prevalence and significance of portal inflammation in a cohort of adults diagnosed as having AFLD and NAFLD.MethodsFrom a histology database, the authors identified 160 patients with biopsy proven AFLD and 214 with NAFLD diagnosed between 1991 and 2001. All liver biopsies were reviewed by one pathologist to evaluate various histological features.ResultsMore than a mild degree of portal inflammation was found in 47% of AFLD compared with 30% in NAFLD subgroup. A higher degree of portal inflammation in AFLD was associated with a higher mean corpuscular volume, gamma glutamyl transferase (GGT) and alkaline phosphatase, and a lower platelet count and albumin, whereas in NAFLD this was associated with age, presence of diabetes, hypertension, body mass index (BMI), higher fasting blood glucose, cholesterol, alanine transaminase, GGT and ferritin. On regression analysis, portal inflammation was associated with the severity of steatosis (p=0.005), presence of ballooning (p=0.030) in NAFLD and severity of fibrosis in both AFLD and NAFLD (p<0.001).ConclusionsPortal inflammation is a common component of histological spectrum of both AFLD and NAFLD. In both conditions portal inflammation is associated with clinical and histological features suggestive of advanced disease.
Hunghom Peninsula in Hong Kong (A), (B) & (C): A Realistic Call for Corporate Social Responsibilities
Authors: Tsai Terence , Liu Shubo Philip 
Published: September 2010

The residential building complex of Hunghom Peninsula was built under the Hong Kong government's Private Sector Participation Scheme (PSPS) program that was intended to provide housing for middle-class residents at a discounted price. Due to an economic downturn and a shrinking real estate market threatening property values, Hunghom was later sold to the private property developers who originally built the complex. The developers, New World Development Company Limited (NWD) and Sun Hung Kai Properties Limited (SHKP) came up with a reconstruction proposal for Hunghom Peninsula: demolish and redevelop the area into a luxurious private estate. However, the intention to demolish the never-occupied Hunghom Peninsula came under heavy criticism from the public in large part because the demolition process would produce extensive pollution to the environment, which violated both social parties and the companies' corporate mission of being responsible to the society. Under these circumstances, the management team had to withdraw the demolition plan and reconsider their decision. After the developers thought twice about all the relevant parties' interests and took corporate social responsibility into account, they gave up the demolition plan and decided to conduct an extensive internal reconfiguration and renovation to upgrade the property to medium-grade private housing estate standard. Case (A) describes the backgrounds of Hunghom Peninsular Project and its developers, describes Hong Kong's business environment and introduces the three options faced by decision makers. Case (B) reveals NWD and SHKP's choice of the options and the opposition voices against their initial choice. In Case (C) developers give in to pressure from protestors and change their initial decision, in favor of a more environmental option. Case (C) brings the story to a close.
BIOMIMETIC ELECTROSPUN GELATIN–CHITOSAN POLYURETHANE FOR HEART VALVE LEAFLETS
Authors: WONG CYNTHIA , SHITAL PATEL , CHEN RUI , OWIDA AMAL , MORSI YOS 
Published: September 2010

Native heart valve leaflets are subjected to continuous pulsatile and homodynamic forces and can be as thin as 300 μm. For a proper function of the valve the materials selected for the leaflets need to be biocompatible, robust, flexible, and have comparable mechanical properties to the natural ones.In this paper, biocompatibility and cell retention ability for gelatin–chitosan polyurethane (PU), polyglycolide (PGA)/PLA and collagen-coated bovine pericardium were examined and their mechanical properties were tested. Endothelial cells, isolated from ovine carotid arteries were seeded onto these materials and exposed to a range of shear-stresses for a period of 1–3 h.The findings indicated that throughout the exposure time and the shear-stress range tested, a mean cell retention rate of 80% was obtained in the gelatin–chitosan PU group. However, for PGA/PLA and pericardium groups it was found that as the exposure time of shear-stress increased, a significant cell reduction was observed. Noticeably for all the range of physiological flow conditions tested, the electrospun gelatin–chitosan PU demonstrated good biocompatibility and cell retention properties and could be potentially used as a biomaterial for tissue engineering of heart valves.
Colorectal Tumors Are Effectively Eradicated by Combined Inhibition of β-Catenin, KRAS, and the Oncogenic Transcription Factor ITF2
Authors: Mologni Luca , Dekhil Hafedh , Ceccon Monica , Purgante Stefania , Lan Cathy , Cleris Loredana , Magistroni Vera , Formelli Franca , Gambacorti-Passerini Carlo B. 
Published: September 2010

Abstract
Colorectal carcinomas (CRC) harbor well-defined genetic abnormalities, including aberrant activation of β-catenin (β-cat) and KRAS, but independent targeting of these molecules seems to have limited therapeutic effect. In this study, we report therapeutic effects of combined targeting of different oncogenes in CRC. Inducible short hairpin RNA (shRNA)–mediated silencing of β-cat, ITF2, or KRAS decreased proliferation by 88%, 72%, and 45%, respectively, with no significant apoptosis in any case. In contrast, combined blockade of β-cat and ITF2 inhibited proliferation by 99% with massive apoptosis. Similar effects occurred after combined shRNA against β-cat and KRAS. In vivo, single oncogene blockade inhibited the growth of established tumors by up to 30%, whereas dual β-cat and ITF2 targeting caused 93% inhibition. Similar tumor growth suppression was achieved by double β-cat/KRAS shRNA in vivo. Our findings illustrate an effective therapeutic principle in CRC based on a combination targeting strategy that includes the ITF2 oncogene, which represents a novel therapeutic target. Cancer Res; 70(18); 7253–63. ©2010 AACR.