bluuebunny/crossref_metadata_2025_split huggingface dataset:
Artificial neural network-based computational algorithm of inverse sumudu transform applied to surface transient electromagnetic sounding method
Authors: Эпов М.И. , Даниловский К.Н. , Нечаев О.В. , Михайлов И.В. 
Published: May 2024

Рассматриваются результаты разработки нейросетевого алгоритма обратного преобразования Сумуду применительно к задаче наземного нестационарного электромагнитного зондирования. Преобразование Сумуду перспективно для решения прямых задач геоэлектрики в трехмерных моделях сред, поскольку, в отличие от использования преобразования Лапласа или Фурье, Сумуду-изображение действительной функции также является действительной функцией. Таким образом, при последующих вычислениях не возникает необходимости прибегать к комплексным числам, что снижает вычислительные затраты и требования к оперативной памяти в случае успешного определения Сумуду-изображения функции. К недостаткам подхода можно отнести отсутствие явного способа вычисления обратного преобразования. Обращение можно осуществить путем решения соответствующего интегрального уравнения Фредгольма первого рода, однако это является плохо обусловленной задачей и приводит к высоким требованиям к точности получения Сумуду-изображения. Применение современных технологий машинного обучения может обеспечить получение метода, более устойчивого к шуму во входных данных. В работе описывается процесс создания обучающего набора данных и разработки нейросетевого алгоритма, оценивается точность и производительность разработанного решения. Предложенный способ позволит развивать новые подходы к моделированию физических процессов, анализу, обработке и интерпретации измеренных геофизических данных.
The paper discusses the results of the development of a deep learning-based algorithm of the inverse Sumudu transform applied to the problem of on-ground non-stationary electromagnetic sounding. The Sumudu transform has potential for solving forward geoelectric problems in three-dimensional earth models because, unlike using the Laplace or Fourier transform, the Sumudu image of a real function is also a real function. Thus, there is no need to use complex numbers in subsequent calculations, which reduces computational costs and memory requirements in case of successful determination of the Sumudu image of the function. The disadvantages of the approach include the absence of an explicit method for calculating the inverse transform. The inversion can be done by solving the corresponding Fredholm integral equation of the first kind, but this is a poorly conditioned task leading to high requirements for the accuracy of the Sumudu image. The use of modern machine learning techniques can provide a method that is more robust to noise in the input data. This paper describes the process of creating a training dataset and developing a neural network algorithm; we evaluate the accuracy and performance of the obtained solution. The proposed method can contribute to the development of new approaches to physical processes modeling as well as to analysis, processing and interpretation of measured geophysical data.
Structure of the hydrothermal system of thermal fields inferred from geological-geophysical modeling: a case study of the kambalny volcanic ridge (kamchatka)
Authors: Нуждаев И.А. , Рычагов С.Н. , Феофилактов С.О. , Букатов Ю.Ю. 
Published: May 2024

На основании комплексных структурно-геофизических исследований и обобщения геофизических, гидрогеологических, минералого-геохимических и других данных показано, что термальные поля южной группы Камбального вулканического хребта (Южная Камчатка) входят в состав современной гид­ротермальной системы. Получены новые данные о строении зоны разгрузки парогидротерм до глубины около 300 м. Установлена структурная и гидродинамическая связь двух термальных полей этой группы. Предполагается единое тепловое питание геотермальной системы Камбального хребта, объединяющей все основные группы термальных полей.
Based on integrated structural and geophysical studies and generalization of geophysical, hydrogeological, mineralogical, geochemical and other data, it is shown that the southern cluster of thermal fields of the Kambalny volcanic ridge (South Kamchatka) is included in the modern hydrothermal system. New data on the structure of the steam hydrotherm discharge area investigated to a depth of about 300 m have been obtained. The structural and hydrodynamic connection between two thermal fields from this group has been established. The Kambalny ridge geothermal system embracing all major clusters of thermal fields is assumed to have a single deep-seated source of heat supply.
The Effect of Calcitonin Gene-Related Peptide Monoclonal Antibodies on Quality of Life among Migraine Patients: Pilot Study at the Hospital of Lithuanian University of Health Sciences Kaunas Clinics
Authors: Remenčiūtė Monika , Varžaitytė Greta , Žemgulytė Gintarė 
Published: May 2024

Background: Migraine has a negative impact on patients’ quality of life, with the frequency of attacks being associated with greater disability and poorer health status. Frequent migraine-type headaches require prophylactic treatment, which has so far been of limited effectiveness until advent of calcitonin gene-related peptide (CGRP) monoclonal antibody.Materials and Methods: A prospective analysis was conducted of data from 41 migraine patients who experienced 4 or more monthly migraine days (MMD) longer than three months. At the beginning of the study, treatment with monoclonal antibodies against CGRP (fremanezumab 225 mg or erenumab 70 or 140 g per month) was prescribed according to the indications. The effect of the medications was evaluated after 3-month period.Results: The mean age of patients was 37.17 (±11.78) years. It was found that 17 patients (41.5%) had episodic migraine (EM) and 24 (58.5%) had chronic migraine (CM). Fremanezumab was prescribed to 26 patients (63.4%) and erenumab to 15 patients (36.6%); among the latter, 13 patients used 70 mg/month and 2 patients used 140 mg/month. Three months after treatment, CM changed to EM for 19 patients (79.2%), 27 patients (65.9%) had ≥50% reduction in the number of MMD and total migraine disability assessment (MIDAS) score was reduced by >50% in 31 patients (75.6%). Also, all areas of quality of life of patients were improved after 3 months continued treatment compared to baseline.Conclusions: For more than half the patients using fremanezumab or erenumab after 3-month period, MMD decreased by ≥50% and total MIDAS score by >50 points. All areas of quality of life were improved after prophylactic treatment of migraine.
Survival after Consecutive Myocardial Infarction and Stroke: A Case Report
Authors: Ratautė Kristina , Burneikaitė Greta , Badarienė Jolita 
Published: May 2024

Background: Myocardial infarction and stroke are prevalent and potentially fatal urgent medical conditions. Stroke as a subsequent cardiovascular event after the myocardial infarction significantly decreases the odds of survival for the patient.Clinical case: We report a case of a 48-year-old man admitted to Vilnius University Hospital Santaros Klinikos due to an ST-segment elevation myocardial infarction. Patient also experienced a cardioembolic cerebral infarction on the tenth day in the hospital. The patient survived this dual infarction, his general condition improved and he was discharged to the rehabilitation center.Discussion and Conclusions: Cardiovascular diseases are the most common cause of death in the world. Stroke, as a complication of myocardial infarction, affects 0.76–3.2% of patients and demonstrates an increasing incidence trend. In such a dual infarction, in-hospital mortality can be as high as 18–41%. It is hopeful that targeted research and evidence-based prevention with treatment can improve outcomes of concomitant myocardial infarction and stroke.
The Assessment of CDX1, IHH, SHH, GATA4, FOXA2, FOXF1 in Congenital Intra-Abdominal Adhesions
Authors: Freijere Pope Helēna , Pilmane Māra , Junga Anna , Pētersons Aigars 
Published: May 2024

Congenital abdominal adhesions are a rare condition that can result in a small bowel obstruction at any age, more frequently in pediatric populations. The cause remains unknown, and the importance of aberrant congenital bands is related to the difficulty of diagnosis, and cases of death with late detection have been documented. This research examines the expression of Caudal Type Homeobox 1 (CDX1), Indian Hedgehog (IHH), Sonic Hedgehog (SHH), GATA Binding Protein 4 (GATA4), Forkhead Box A2 (FOXA2) and Forkhead Box F1 (FOXF1) gene expression in human abdominal congenital adhesion fibroblast and endothelium cells by chromogenic in situ hybridization, with the aim of elucidating their potential association with the etiology of congenital intra-abdominal adhesion band development. The potential genes’ signals were examined using a semi-quantitative approach. Significant correlations were observed between the expression of CDX1 (p <.001) and SHH (p=0.032) genes in fibroblasts from congenital intra-abdominal adhesions compared to fibroblasts from control peritoneal tissue. Statistically significant very strong correlations were found between the CDX1 and IHH comparing endothelium and fibroblast cells in congenital abdominal adhesion bands. There was no statistically significant difference found in the distribution of IHH, FOXA2, GATA4, and FOXF1 between the fibroblasts and endothelium of the patients compared to the control group. The presence of notable distinctions and diverse associations suggests the potential involvement of numerous morpho-pathogenetic processes in the development of intraabdominal adhesions.
EU Sustainability Quest: Possibilities of Consumer Sales
Authors: Selvestravičiūtė Agnė 
Published: May 2024

This paper analyses principal incoherence left in EU rules applicable to consumer sales against the background of the European Commission’s sustainability quest, supposedly influencing every area of the Union’s future life, and argues for a possible need for changes in contemporary consumer law in order to achieve a greater environmental good. It covers three key aspects where the Consumer Sales Directive might have done a better job in addressing environmental worries (i. e. legal guarantee term, assessment of remedies, and commercial guarantees), and states that these aspects were not modified to benefit the environment. The article then covers a deeper problem of conflicting aims that cannot be simultaneously upheld (i. e. fostering and curbing consumption at the same time), and challenges that in order to address environmental problems serious reconsiderations of consumer protection might be necessary.
Dyscyplina pracy w wybranych polskich organizacjach – problemy karania w opinii pracowników
Authors: Pokrzywa Magdalena 
Published: May 2024

Celem artykułu jest ukazanie opinii pracowników wybranych polskich organizacji na temat dyscypliny, ze szczególnym uwzględnieniem problematyki karania. W artykule skoncentrowano się na opiniach badanych dotyczących częstotliwości karania, dominujących form karania, najczęstszych kar nieformalnych stosowanych w organizacjach zatrudniających badanych oraz emocji towarzyszących respondentom w sytuacji podlegania karze. Badania zrealizowano za pomocą techniki CAWI z 393 pracownikami reprezentującymi różne organizacje w Polsce. Respondenci deklarowali, że na ogół kary formalne stosowane są bardzo rzadko, jednak kary nieformalne występują w większości organizacji zatrudniających badanych. W wyniku stosowania kar następuje najczęściej spadek motywacji do pracy oraz brak satysfakcji z pracy. Karom towarzyszyło również poczucie niesprawiedliwości.
When Leaving is Persisting
Authors: Klein-Latucha Orly , Hershkovitz Arnon 
Published: May 2024

We report on a large-scale, log-based study of the associations between persistence and success in an online game-based learning environment for elementary school mathematics. While working with applets, learners can rerun a task after completing it or can halt before completing and rerun it again; both of these mechanisms may improve the score. We analyzed about 3.1 million applet runs by N=44,323 1st–6th-grade students to have a nuanced understanding of persistence patterns, by identifying sequences of consecutive single applet runs (SoCSARs). Overall, we analyzed 2,249,647 SoCSARs and identified six patterns, based on halting and rerunning tasks, and their completion: 1) Single Complete, 2) Single Incomplete, 3) Some Incomplete and Single Complete, 4) Multiple Incomplete and No Complete, 5) Multiple Complete and No Incomplete, and 6) Multiple Complete and Some Incomplete. Expectedly, we found a positive correlation between SoCSAR length and success. Some patterns demonstrate low to medium positive associations with success, while others demonstrate low to medium negative associations. Furthermore, the associations between the type of persistence and success vary by grade level. We discuss these complex relationships and suggest metacognitive and motivational factors that may explain why some patterns are productive and others are not.
CJEU Decision C-107/23 PPU: Insights on the Protection of the EU Financial Interests and the National princIple of ”Lex Mitior”
Authors: Viorescu Razvan 
Published: May 2024

The request came from a Romanian court in the context of an extraordinary appeal against a previous decision of that court, in which the appellants were sentenced to imprisonment and to pay damages for tax evasion and the setting up of a criminal organisation. The extraordinary appeal is a special procedure in Romania and allows a plaintiff to seek the annulment of definitive judgements in criminal matters when a sentence was pronounced despite the existence of grounds liable to end criminal proceedings. This situation led Romanian courts to adopt non-uniform case law regarding the interruption of limitation periods. To cease the uncertainty, the RCC stressed, in 2022, that the interruption of limitation periods is part of substantive criminal law (not procedural) and is thus covered by the principle of legality and of retroactive application of the lex mitior. The RCC drew the conclusion that, following the adoption of its decision in 2018 and the failure of the legislator to put the law in line with that decision, Romanian criminal law should be understood as not providing for any ground of interruption of the limitation periods. As a result, pending criminal proceedings could be ended if a definitive judgment has not been delivered within the uninterrupted limitation period. Following the 2022 decision, the Romanian legislator adopted a normative act enumerating the grounds for interruption of the limitation periods. However, Lin concerns the effects of the 2022 decision on situations where a person has been convinced by a definitive judgement, but an extraordinary appeal is intended.
Which casein micelle removal method is suitable for studies of human milk extracellular vesicles? A systematic comparison of four different treatments for casein depletion before extracellular vesicle isolation from human milk
Authors: Cetinkaya Hatice , Kongsomros Supasek , Nommsen-Rivers Laurie , Morrow Ardythe L. , Chutipongtanate Somchai 
Published: May 2024

Aim: This study aimed to systematically compare four casein micelle removal methods on the particle and protein characteristics of the isolated human milk EVs.
Methods: The defatted milk was treated with 1% sodium citrate, 20 mM ethylenediaminetetraacetic acid (EDTA), 1% acetic acid, or 1% chymosin/calcium chloride for 30 min at 4 °C to remove casein micelles. EV isolation was performed using qEV size exclusion chromatography. Milk turbidity at the optical density 350 nm and dot immunoblot with casein antibody were applied to monitor the qEV fractions. Particle analyses were performed using transmission electron microscopy (TEM) and nanoparticle tracking analysis (NTA). The enrichment of human milk EV markers, i.e., tetraspanins, Alix, lactadherin, butyrophilin, and xanthine dehydrogenase, and casein depletion capabilities were evaluated by proteomics and immunoblotting.
Results: Compared to the untreated condition, sodium citrate and EDTA decreased milk turbidity by disrupting casein micelles, while acetic acid and chymosin removed them by inducing precipitation/coagulation. All treatments shifted casein immunoreactivity in the qEV fractions from large micelles (the exclusion volume) to small molecular sizes (gel-infiltrated fractions). Acidification affected human milk EV morphology, while EDTA, acetic acid, and chymosin methods slightly altered EV particle numbers. Different casein micelle removal methods confer different degrees of human milk EV marker enrichment and casein depletion. The method performances could be ranked as follows: chymosin > EDTA > acetic acid > sodium citrate.
Conclusion: Our findings suggest that chymosin and EDTA should be considered as the method of choice for casein micelle removal in future studies involving human milk EV isolation and characterization.
Agglomerative Nesting Cluster Analyst in Mapping District/City Health Facilities in West Java Province
Authors: Alwani Nadira Nisa , Megawati Megawati , Fitrianto Anwar , Erfiani Erfiani , Pradana Alfa Nugraha 
Published: May 2024

The use of Hierarchical Clustering is used to group districts or cities in West Java according to the number of health facilities, distance to health facilities and population density using Agglomerative Nesting (AGNES). Clustering in this study utilizes complete linkage clustering. The elbow method produces two optimal clusters which are then validated with the sillhoute coefficient and Calinski-Harabasz. In this study, there are 27 variables in the form of health facilities spread across 27 regencies/cities in West Java in 2021. The results of the cluster analysis formed in this study are 18 districts/cities in cluster one and 9 districts/cities in cluster two
Fastabiq al-khairat: Wujud Etika Profesi Berkeadilan
Authors: Aripratiwi Ratna Anggraini 
Published: May 2024

<em><span lang="EN-US">This study aims to cultivate the spirit of Fastabiq al-khairat, a competition in goodness, as the foundation for professional ethics in public accounting. The Public Accountant Professional Code of Ethics (KEPAP in Indonesia), issued by IAPI, serves as the basis for the implementation of accounting work. The principles outlined in the code of ethics still tend to be world-centric, highlighting the importance of incorporating Divine values into professional practices. To explore this, the study employs Islamic ethnographic methods, conducting interviews with participants and analyzing their values through the lens of Fastabiq al-khairat. The study proposes instilling the spirit of Fastabiq al-khairat into the fundamental principles of professional ethics, with intention as the cornerstone. The implication of this research is to offer an alternative perspective distinct from the Western benchmark used to gauge ethical behavior success. By integrating the values of Fastabiq al-khairat into the core principles of accounting professional ethics, a just and fair ethical framework can be established for fulfilling mandates and responsibilities. The anticipated outcome of this research is to introduce the concept of Islamic values, specifically Fastabiq al-khairat, as a guiding force in the development of professional ethics within the field of public accounting. </span></em>
Enhancing SS 400 Metal Weld Quality through Current Optimization
Authors: Sudrajat Risvanda Amin , Akbar Ali 
Published: May 2024

This study investigates the impact of varying welding electric current strengths (70 A, 100 A, and 130 A) on SS 400 metal welding using Shielded Metal Arc Welding (SMAW) with an E6013 electrode. The aim is to identify the optimal current strength for minimizing defects and enhancing weld quality. Liquid penetrant testing is employed to detect welding defects, with results showing that excessively low or high current strengths result in increased defects, such as holes and red spots. The findings highlight the importance of utilizing an electric current around 100 A to achieve optimal weld quality, while liquid penetrant testing proves effective for defect detection and quality assessment, aiding in early prevention of corrosion and other issues in welding processes.
Highlight:

Optimizing Welding Parameters: Essential for minimizing defects and enhancing SS 400 metal weld quality.
Effective Defect Detection: Liquid penetrant testing aids in identifying welding flaws efficiently.
Enhanced Weld Quality: Utilizing optimal electric current strength improves weld integrity effectively.

Keywoard: Welding, SS 400 metal, Shielded Metal Arc Welding, Electric current, Liquid penetrant testing
Measurement of Health-Related Quality of Life in Adult Patients with Rare disease: Based on the Chinese Value Set EQ-5D-5L
Authors: Zhong xiaoqing , Li Zhiying , Gao Lijie , Zhong Weiheng , Jiang Shiyuan , Xia Jie , Ren Hang , Xia Sujian 
Published: May 2024

Abstract

Background
Rare disease is a general term for a class of diseases with low incidence rate/prevalence. About 10% of the world's people are affected by rare disease, and China has about 20 million patients with rare disease. Patients with Rare disease usually face difficulties in diagnosis, no effective treatment, heavy medical burden and low quality of life. These difficulties may be more prominent in Chinese Mainland, where rare disease policy started late. This paper used EQ-5D-5L to investigate the health-related quality of life (HRQoL) of patients with rare disease in Foshan City, Guangdong Province, the pilot area for the development of policies on rare disease in China, and explored its predictive factors.
Methods
From March 2022 to June 2022, rare disease organized The Illness Challenge Foundation to recruit patients with rare disease in Foshan City, Guangdong Province, China. After obtaining informed consent, a survey questionnaire was sent online to the patients, which included the patient's socio-economic situation, medical characteristics of the disease, and the Chinese version of the EQ-5D-5L scale. Using Tobit regression to explore factors related to patients' HRQoL.
Results
A total of 104 patients were included in the study, covering 20 independent rare disease. The average utility score reported by patients was 0.62 ± 0.33 (range, -0.391 to 1). Most respondents experienced anxiety/depression (80.8%), followed by pain/discomfort (78.2%), daily activities (72.1%), activity ability (68.3%), and self-care (35.6%). Seven patients (6.7%) reported negative utility scores, indicating a worse health condition than death. Tobit regression analysis shows that higher direct medical expenses, direct non-medical expenses, greater need for care, access to social organization assistance, and experience of discrimination are negatively correlated with EQ-5D-5L scores.
Conclusions
The HRQoL of patients with rare disease is poor. Anxiety/depression and pain/discomfort are the most frequently reported problems. Economic and social support resources are predictive factors for patients' HRQoL, and should be given priority consideration in policy formulation.