bluuebunny/crossref_metadata_2025_split huggingface dataset:
PROBLEMATIKA KETIDAKADILAN LINGKUNGAN DALAM PENGELOLAAN WILAYAH PESISIR DI INDONESIA
Authors: Muhamad Agil Aufa Afinnas  
Published: June 2024

Abstract
Environmental injustice often occurs in coastal area utilization activities due to the neglect of social and environmental interests for economic interests. In this research, the problem of environmental injustice in coastal area management will be analyzed using the Taxonomy of Environmental Justice framework. Furthermore, reflection will be carried out using the Job Creation Perpu concerning environmental injustice in coastal areas. This research uses doctrinal legal research method. This research will indicate environmental injustice in the form of distributive, corrective, procedural, and social injustice. Distributive injustice is related to the unequal distribution of risks and benefits of coastal area management activities. Corrective injustice occurs because environmental law enforcement is still weak and the legal norms are also nonideal for justice awakening. Procedural injustice is related to the obstacles in accessing the right to information, the right to participation, and the right to justice. There are also social injustice related to the welfare problems of coastal communities. However, The Job Creation Perpu is considered unable to overcome the problem of environmental injustice that occurs in coastal area management so far.

Abstrak
Permasalahan ketidakadilan lingkungan masih sering terjadi di tengah aktivitas pemanfaatan wilayah pesisir. Ketidakadilan lingkungan dapat muncul akibat diabaikannya kepentingan sosial dan lingkungan hidup demi kepentingan ekonomi. Dalam penelitian ini, problematika ketidakadilan lingkungan dalam konteks pengelolaan wilayah pesisir akan dikaji menggunakan kerangka Taksonomi Keadilan Lingkungan. Selanjutnya, akan dilakukan refleksi terhadap Perpu Cipta Kerja dalam kaitannya dengan ketidakadilan lingkungan di wilayah pesisir. Metode penelitian yang digunakan adalah penelitian hukum doktrinal.Hasil dari penelitian ini menunjukkan bahwa ketidakadilan lingkungan, yang berupa ketidakadilan distributif, prosedural, korektif, dan sosial masih terjadi. Ketidakadilan distributif masih terjadi berkaitan dengan distribusi risiko atau dampak dan manfaat dari aktivitas pengelolaan wilayah pesisir yang timpang. Ketidakadilan prosedural yang terjadi berkaitan dengan adanya hambatan pemenuhan hak atas informasi hak akses partisipasi, dan akses keadilan. Ketidakadilan korektif terjadi akibat masih lemahnya penegakan hukum lingkungan dan norma yang ada juga belum ideal untuk mewujudkan keadilan. Yang terakhir, ketidakadilan sosial terjadi berkaitan dengan permasalahan kesejahteraan masyarakat pesisir. Akan tetapi, Perpu Cipta Kerja dinilai belum dapat mengatasi ketidakadilan lingkungan dalam pengelolaan wilayah pesisir.
PENGATURAN HAK ASASI MANUSIA DAN PELINDUNGAN HUKUM MASYARAKAT ADAT DI SEKTOR USAHA PERTAMBANGAN
Authors: Sutan Sorik  , Anang Dwiatmoko  
Published: June 2024

Abstract
This study aims to examine the human rights issues of indigenous peoples in mining areas. The research method used is qualitative with a normative juridical form. From the research conducted, it was found that the practice of utilizing natural resources in the last five decades still found many violations of human rights, especially those related to the rights of indigenous peoples. There are various conflicts over the rights to control and use of natural resources between indigenous peoples and the government or mining permit holders. These problems occur because the laws and regulations related to natural resources are still characterized by being centralized with reference to state-based resource management. The regulations made prioritize a sectoral approach, oriented to exploitation by ignoring the interests of conservation and sustainability of natural resources in order to achieve economic growth targets, prioritizing the interests of large-scale investors. So that there is a need for changes to the laws and regulations of the natural resource sector, especially in the mining sector, as well as encouraging the government to immediately ratify the draft law on indigenous peoples, as an effort to protect the rights of indigenous peoples in mining areas.

Abstrak
Penelitian ini mengkaji problematika pelanggaran hak asasi manusia masyarakat adat di daerah pertambangan. Metode penelitian yang dilakukan adalah kualitatif dengan bentuk yuridis normatif. Dari penelitian yang dilakukan ditemukan bahwa praktek pemanfaatan sumber daya alam pada tiga dekade terakhir masih banyak ditemukan pelanggaran hak asasi manusia, khususnya yang berkaitan dengan hak-hak masyarakat adat. Terdapat pelbagai konflik hak penguasaan dan pemanfaatan sumberdaya alam antara masyarakat adat dengan pemerintah atau pemegang izin pertambangan. Problematika tersebut terjadi karena peraturan perundang-undangan terkait sumber daya alam yang masih berciri sentralistik dengan mengacu pada manajemen yang berpusat pada pemerintah (state-based resource management). Peraturan yang dibuat mengedepankan pendekatan sektoral, berorientasi pada eksploitasi dengan mengabaikan kepentingan konservasi dan keberlanjutan sumber daya alam demi pencapaian target pertumbuhan ekonomi, mengutamakan kepentingan para investor berskala besar. Sehingga perlu adanya perubahan terhadap peraturan perundang-undangan sektor sumber daya alam khususnya bidang pertambangan, serta mendorong pemerintah untuk segera mengesahkan rancangan undang-undangan masyarakat hukum adat, sebagai upaya melindungi hak-hak masyarakat adat di daerah pertambangan.
Effects of Individualized Anemia Therapy on Hemoglobin Stability
Authors: Fuertinger Doris H. , Wang Lin-Chun , Jörg David J. , Rivera Fuentes Lemuel , Ye Xiaoling , Casper Sabrina , Zhang Hanjie , Mermelstein Ariella , Cherif Alhaji , Ho Kevin , Raimann Jochen G. , Tisdale Lela , Kotanko Peter , Thijssen Stephan 
Published: June 2024

Key Points

We conducted a randomized controlled pilot trial in patients on hemodialysis using a physiology-based individualized anemia therapy assistance software.Patients in the group receiving erythropoiesis-stimulating agent dose recommendations from the novel software showed improvement in hemoglobin stability and erythropoiesis-stimulating agent utilization.

Background
Anemia is common among patients on hemodialysis. Maintaining stable hemoglobin levels within predefined target levels can be challenging, particularly in patients with frequent hemoglobin fluctuations both above and below the desired targets. We conducted a multicenter, randomized controlled trial comparing our anemia therapy assistance software against a standard population-based anemia treatment protocol. We hypothesized that personalized dosing of erythropoiesis-stimulating agents (ESAs) improves hemoglobin target attainment.

Methods
Ninety-six patients undergoing hemodialysis and receiving methoxy polyethylene glycol-epoetin beta were randomized 1:1 to the intervention group (personalized ESA dose recommendations computed by the software) or the standard-of-care group for 26 weeks. The therapy assistance software combined a physiology-based mathematical model and a model predictive controller designed to stabilize hemoglobin levels within a tight target range (10–11 g/dl). The primary outcome measure was the percentage of hemoglobin measurements within the target. Secondary outcome measures included measures of hemoglobin variability and ESA utilization.

Results
The intervention group showed an improved median percentage of hemoglobin measurements within target at 47% (interquartile range, 39–58), with a 10% point median difference between the two groups (95% confidence interval, 3 to 16; P = 0.008). The odds ratio of being within the hemoglobin target in the standard-of-care group compared with the group receiving the personalized ESA recommendations was 0.68 (95% confidence interval, 0.51 to 0.92). The variability of hemoglobin levels decreased in the intervention group, with the percentage of patients experiencing fluctuating hemoglobin levels being 45% versus 82% in the standard-of-care group. ESA usage was reduced by approximately 25% in the intervention group.

Conclusions
Our results demonstrated an improved hemoglobin target attainment and variability by using personalized ESA recommendations using the physiology-based anemia therapy assistance software.

Clinical Trial registration number:

NCT04360902.
Neonatal Amino Acids and Acylcarnitines Associated With Maternal Blood Glucose Levels Throughout Pregnancy: Insights From the Beijing Birth Cohort Study
Authors: Zheng Wei , Yuan Xianxian , Zhao Jinqi , Han Weiling , Huang Junhua , Yan Xin , Zhang Lirui , Li Lulu , Wang Shunan , Kong Yuanyuan , Li Guanghui 
Published: June 2024

OBJECTIVE
To determine the association between maternal blood glucose patterns throughout pregnancy and neonatal amino acids and acylcarnitines.

RESEARCH DESIGN AND METHODS
We conducted a prospective cohort study involving 11,457 singleton pregnant women without preexisting diabetes from the Beijing Birth Cohort Study, along with their neonates born between July 2021 and October 2022 in Beijing, China. Distinct maternal glucose trajectories were identified using a latent class model based on blood glucose levels across the three trimesters, and their association with neonatal circulating metabolites, including 11 amino acids and 33 acylcarnitines, was examined, adjusting for potential confounding factors.

RESULTS
Three distinct groups of maternal glucose trajectories were identified: consistent normoglycemia (n = 8,648), mid-to-late gestational hyperglycemia (n = 2,540), and early-onset hyperglycemia (n = 269). Mid-to-late gestational hyperglycemia was associated with decreased levels of amino acids (alanine, arginine, ornithine, and proline) involved in the arginine and proline metabolism and urea cycle pathway, as well as increased levels of C4DC+C5-OH and decreased level of C6DC and C10:1. Early-onset hyperglycemia was associated with elevated levels of free acylcarnitine and C4DC+C5-OH and a decreased level of C10:1, involved in the fatty acid oxidation pathway. However, these associations were primarily observed in male neonates rather than in female neonates.

CONCLUSIONS
Our findings revealed a significant link between maternal glucose trajectories throughout pregnancy and neonatal arginine and proline metabolism, urea cycle pathway, and fatty acid oxidation pathway. These results highlight the importance of maintaining optimal blood glucose levels throughout pregnancy to promote healthy neonatal metabolic outcomes.
PENGUKURAN PENGETAHUAN PENYAKIT KANKER PAYUDARA DAN PEMANFAATAN BAHAN ALAM UNTUK PENYAKIT TERSEBUT PADA MASYARAKAT DESA CILIANG KECAMATAN PARIGI KABUPATEN PANGANDARAN
Authors: Amalia Eri , Sopyan Iyan , Maisyarah Intan Timur , Putriana Norisca Aliza , Sriwidodo Sriwidodo 
Published: June 2024

Penderita penyakit kanker payudara diketahui semakin meningkat hampir di setiap negara termasuk juga di Indonesia. Kendatipun bukan merupakan penyakit menular, penanganan kanker payudara perlu mendapatkan perhatian serius karena dapat menyebabkan kematian bagi penderita. Sosialisasi aktif kepada masyarakat mengenai pencegahan dan penanganan penyakit sejak dini merupakan salah satu upaya untuk mengurangi terjadinya kasus ini. Pemahaman mengenai pemanfaatan bahan alam yang berkhasiat dalam terapi kanker payudara juga perlu diketahui oleh masyarakat, untuk memberikan harapan dan mendukung penemuan obat kanker yang berasal dari bahan alam. Penelitian yang dilakukan di desa Ciliang Kecamatan Parigi Kabupaten Pangandaran Provinsi Jawa Barat ini bertujuan untuk mendapatkan informasi tentang pengetahuan masyarakat desa tersebut mengenai penyakit kanker payudara. Metode penelitian dalam pengumpulan data dilakukan dengan kuestioner model tes dikotomi mengenai pengenalan, gejala, faktor penyebab, pemeriksaan payudara sendiri (SADARI), pemanfaatan bahan alam untuk terapi kanker payudara. Pengolahan dan analisis data dilakukan dengan skala likert. Kegiatan penyuluhan dilakukan setelah pengumpulan data untuk memberikan informasi dan penjelasan mengenai kanker payudara dan pemanfaatan bahan alam untuk penyakit tersebut. Hasil penelitian menunjukkan bahwa masyarakat desa Ciliang telah memiliki pengetahuan yang baik mengenai kanker payudara dan pemanfaatan bahan alam untuk penyakit tersebut dengan skor rata-rata responden adalah 17,15 dan rentang nilai 14-21 dari total nilai 25, yang menunjukkan tingkat pengetahuan yang baik hingga sangat baik. Namun, sosialisasi mengenai kanker payudara tetap harus dilakukan berkala terutama mengenai cara deteksi dini melalui teknik SADARI. Penelitian ini adalah upaya kami dalam turut meningkatkan kesadaran masyarakat dalam mencegah dan menurunkan tingkat kematian akibat kanker payudara.
Preparation and Study of Structural, Optical and Electrical Properties of the Composite Films [PVA-PEO-MnCl2.4H2O]
Authors: Hameed Alaa , Sabah A. Salman  
Published: June 2024

In the present paper, pure polymeric blend film [PVA-PEO] and the polymeric blend films reinforced by MnCl2.4H2O salt with different weight ratios (10, 20, 30, 40, 50 wt %) have been prepared by using the solution casting method. The effects of weight ratio of salt on structural properties for all reinforced polymeric blends films were studied. FTIR spectra were used to establish the interaction between the polymer (PVA) and the polymer (PEO) reinforced by MnCl2.4H2O salt, which causes some changes in the vibration modes and the position of the bonds. All inrestigated samples exhibited broad bonds at around (3310 cm-1). The results showed the asymmetric vibration of O-H group in the polymers matrix. The peaks around (2880 cm-1) can be attributed to the presence of C- H stretching vibration group. The C=C stretching vibration appears in the bonds at (1955 cm-1). The peak at (1096 cm-1) for all reinforced films is attributed to the stretching mode of C-O-C stretching. There is a shift of out-of-plane rings C-H bending vibration from 961.2 to 955 cm-1. These indicate the chemical interactions of MnCl2.4H2O salt with the polymeric blend [PVA-PEO]. The two strong bonds observed around (1471 cm-1 and 844 cm-1) are assigned to the bending and stretching vibration of the CH2 group, respectively. The change in the spectral intensities of polymeric blend [PVA-PEO] involves a shift in some bonds due to the MnCl2.4H2O salt addition. The effects of weight ratio of salt on optical properties for all reinforced polymeric blends films were studied, as the transmittance and absorbance spectra were recorded within the range of wavelengths (190-1100) nm, and it was found that the energy gap value decreases with an increase of the added salt’s weight ratio. Results showed that the indirect electronic transitions are allowed. Effects of salt’s weight ratio on electrical (dielectrical) properties for all reinforced polymeric blends films were studied, and the practical results showed a decrease in the dielectric constant (ε΄) with an increase in frequency for all polymeric blends films, while the practical results also showed an increase in the alternating electrical conductivity (σa.c) with increasing frequency for all polymeric blends films, as well as an increase in both the dielectric constant and alternating electrical conductivity with an increase in the added salt’s weight ratio at same frequency.
The (Mal)Functionality of Vernacular
Authors: Bronner Simon J. 
Published: June 2024

Abstract
Continuing a dialogue with Ülo Valk on the value of the etic term vernacular in folk-loristic scholarship, this essay responds to his claim that despite the stigma of the word’s past usage and its rejection by other fields it holds promise for folkloristics because of its conceptual flexibility, which he finds is especially conducive to the study of belief and religious practices. Pointing out that flexibility – or “fuzziness” to quote other critics – suggests imprecision, residualism, hierarchy, and lack of analytical instrumentality, this essay contends that use of vernacular reveals more about its users than the groups and practices it purports to describe. Recounting the intellectual history of the term and its adoption in folkloristic circles as well as the author’s own scholarship, this essay maintains that the term has limited, if any, use in folkloristics and ethnology because of its negative assumptions and “fuzzy” logic. It can be reflexively analyzed, however, to understand scholars’ perceptions of cultural phenomena and their conflicts with cognitive categories of practice and belief enacted by cultural participants.
A Near-Death Experience Narrated by a Vepsian Woman
Authors: Arukask Madis , Saar Eva 
Published: June 2024

Abstract
This article* focuses on the immediate near-death experience of an elderly woman living in traditional Vepsian culture. We analyse which universal, and which more culturally motivated features are present in her story narrated to us in 2018. We conclude that, despite the strong association with animistic beliefs in the informant’s everyday life, the experience is dominated by elements specific to vernacular Orthodox Christianity. The article presents a translation from Vepsian of a fragmentary personal experience narrative.
Machine learning-enhanced gesture recognition through impedance signal analysis
Authors: Huynh Hoang Nhut , Diep Quoc Tuan Nguyen , Dinh Minh Quan Cao , Tran Anh Tu , Dang Nguyen Chau , Phan Thien Luan , Tran Trung Nghia , Ching Congo Tak Shing 
Published: June 2024

Abstract
Gesture recognition is a crucial aspect in the advancement of virtual reality, healthcare, and human-computer interaction, and requires innovative methodologies to meet the increasing demands for precision. This paper presents a novel approach that combines Impedance Signal Spectrum Analysis (ISSA) with machine learning to improve gesture recognition precision. A diverse dataset that included participants from various demographic backgrounds (five individuals) who were each executing a range of predefined gestures. The predefined gestures were designed to encompass a broad spectrum of hand movements, including intricate and subtle variations, to challenge the robustness of the proposed methodology. The machine learning model using the K-Nearest Neighbors (KNN), Gradient Boosting Machine (GBM), Naive Bayes (NB), Logistic Regression (LR), Random Forest (RF), and Support Vector Machine (SVM) algorithms demonstrated notable precision in performance evaluations. The individual accuracy values for each algorithm are as follows: KNN, 86%; GBM, 86%; NB, 84%; LR, 89%; RF, 87%; and SVM, 87%. These results emphasize the importance of impedance features in the refinement of gesture recognition. The adaptability of the model was confirmed under different conditions, highlighting its broad applicability.
Endoscopic management of patients with familial adenomatous polyposis after prophylactic colectomy or restorative proctocolectomy – systematic review of the literature
Authors: Gavric Aleksandar , Sanchez Liseth Rivero , Brunori Angelo , Bravo Raquel , Balaguer Francesc , Pellisé Maria 
Published: June 2024

Abstract

Background
Patients with familial adenomatous polyposis (FAP) develop early colorectal adenomas and if left untreated, progression to cancer is an inevitable event. Prophylactic surgery does not prevent further development of cancer in the rectal remnant, rectal cuff in patients with ileal pouch anal anastomosis (IPAA) and even on the ileal mucosa of the pouch body. The aim of this review is to assess long-term rates of cancer and adenoma development in patients with FAP after prophylactic surgery and to summarise current recommendations for endoscopic management and surveillance of these patients.

Materials and methods
A systematic literature search of studies from January 1946 through to June 2023 was conducted using the PRISMA checklist. The electronic database PubMed was searched.

Results
Fifty-four papers involving 5010 patients were reviewed. Cancer rate in the rectal remnant was 8.8–16.7% in the western population and 37% in the eastern population. The cumulative risk of cancer 30 years after surgery was 24%. Mortality due to cancer in the rectal remnant is 1.1–11.1% with a 5-year survival rate of 55%. The adenoma rate after primary IPAA was 9.4–85% with a cumulative risk of 85% 20 years after surgery and a cumulative risk of 12% for advanced adenomas 10 years after surgery. Cumulative risk for adenomas after ileorectal anastomosis (IRA) was 85% after 5 and 100% after 10 years. Adenomas developed more frequently after stapled (33.9–57%) compared to hand-sewn (0–33%) anastomosis. We identified reports of 45 cancers in patients after IPAA of which 30 were in the pouch body and 15 in the rectal cuff or at the anastomosis.

Conclusions
There was a significant incidence of cancer and adenomas in the rectal remnant and ileal pouch of FAP patients during the long-term follow-up. Regular endoscopic surveillance is recommended, not only in IRA patients, but also in pouch patients after proctocolectomy.
Advancing HER2-low breast cancer management: enhancing diagnosis and treatment strategies
Authors: Borstnar Simona , Bozovic-Spasojevic Ivana , Cvetanovic Ana , Plavetic Natalija Dedic , Konsoulova Assia , Matos Erika , Popovic Lazar , Popovska Savelina , Tomic Snjezana , Vrdoljak Eduard 
Published: June 2024

Abstract

Background
Recent evidence brought by novel anti-human epidermal growth factor receptor 2 (HER2) antibody-drug conjugates is leading to significant changes in HER2-negative breast cancer (BC) best practices. A new targetable category termed ‘HER2-low’ has been identified in tumors previously classified as ‘HER2-negative’. Daily practice in pathology and medical oncology is expected to align to current recommendations, but patient access to novel anticancer drugs across geographies might be impeded due to local challenges.

Materials and methods
An expert meeting involving ten regional pathology and oncology opinion leaders experienced in BC management in four Central and Eastern Europe (CEE) countries (Bulgaria, Croatia, Serbia, Slovenia) was held. Herein we summarized the current situation of HER2-low metastatic BC (mBC), local challenges, and action plans to prevent delays in patient access to testing and treatment based on expert opinion.

Results
Gaps and differences at multiple levels were identified across the four countries. These included variability in the local HER2-low epidemiology data, certification of pathology laboratories and quality control, and reimbursement conditions of testing and anticancer drugs for HER2-negative mBC. While clinical decisions were aligned to international guidelines in use, optimal access to testing and innovative treatment was restricted due to significant delays in reimbursement or limitative reimbursement conditions.

Conclusions
Preventing delays in HER2-low mBC patient access to diagnosis and novel treatments is crucial to optimize outcomes. Multidisciplinary joint efforts and pro-active discussions between clinicians and decision makers are needed to improve care of HER2-low mBC patients in CEE countries.