bluuebunny/crossref_metadata_2025_split huggingface dataset:
Exercise in newly diagnosed patients with multiple myeloma: A randomized controlled trial of effects on physical function, physical activity, lean body mass, bone mineral density, pain, and quality of life
Authors: Larsen Rikke F. , Jarden Mary , Minet Lisbeth R. , Frølund Ulf Christian , Hermann Anne Pernille , Breum Leif , Möller Sören , Abildgaard Niels 
Published: May 2024

AbstractReduced physical function caused by bone destruction, pain, anemia, infections, and weight loss is common in multiple myeloma (MM). Myeloma bone disease challenges physical exercise. Knowledge on the effects and safety of physical exercise in newly diagnosed patients with MM is limited. In a randomized, controlled trial, we studied the effect of a 10‐week individualized physical exercise program on physical function, physical activity, lean body mass (LBM), bone mineral density (BMD), quality of life (QoL), and pain in patients newly diagnosed with MM. Lytic bone disease was assessed, and exercise was adjusted accordingly. Primary outcome: knee extension strength. Secondary outcomes: Six‐Minute‐Walk‐Test, 30‐s Sit‐to‐Stand‐Test (SST), grip strength, level of physical activity, LBM, BMD, QoL, and pain. Measurements were conducted pre‐ and post‐intervention, and after 6 and 12 months. We included 100 patients, 86 were evaluable; 44 in the intervention group (IG) and 42 in the control group (CG). No statistically significant differences between groups were observed. Knee extension strength declined in the IG (p = .02). SST, aerobic capacity, and global QoL improved in both groups. Pain decreased consistently in the IG regardless of pain outcome. No significant safety concerns of physical exercise in newly diagnosed patients with MM were observed.
Overcoming therapeutic challenges: Successful management of a supposedly triple seronegative, refractory generalized myasthenia gravis patient with efgartigimod
Authors: Sorrenti Benedetta , Laurini Christian , Bosco Luca , Strano Camilla Mirella Maria , Scarlato Marina , Gastaldi Matteo , Filippi Massimo , Previtali Stefano Carlo , Falzone Yuri Matteo 
Published: May 2024

AbstractBackground and purposeThis study was undertaken to highlight neonatal Fc receptor inhibition (efgartigimod) as a valuable therapeutic option for patients with refractory seronegative myasthenia gravis (MG) and to emphasize the concept that seronegative MG is greatly constrained by the limitations of currently available diagnostic methods and therapeutic measures.MethodsWe describe the first refractory, generalized MG (gMG) patient successfully treated with efgartigimod after testing negative on standard autoantibody detection tests.ResultsOur patient presented with severe fluctuating bulbar and generalized weakness, resulting in multiple myasthenic crises requiring intubation. After a 28‐year medical history of multiple failed lines of treatment, our patient was started on efgartigimod. Over five treatment cycles, a definite improvement in her clinical condition was observed (Myasthenia Gravis Foundation of America class: IIIb to IIb; MG‐Activities of Daily Living score: 11 to 0; MG‐Quality of Life 15 score: 30 to 0; Quantitative MG score: 28 to 6). Standard autoantibody detection tests failed to detect known pathogenic autoantibodies, but cell‐based assay (CBA) identified autoantibodies against clustered adult acetylcholine receptor (AChR).ConclusionsIn light of recent approvals of efgartigimod by the European Medicines Agency and US Food and Drug Administration exclusively for AChR‐positive gMG forms, our case highlights evidence suggesting that such an approach might be shortsighted and could limit therapeutic options for patients with refractory seronegative gMG. Additionally, introducing more sensitive analytical techniques, exemplified by CBA, may help bridge the gap between seronegative and seropositive patients. This represents an urgent unmet need for gMG patients, as the antibody profile dramatically influences the therapeutic approach.
Taxonomic inflation as a conservation trap for inbred populations
Authors: Clavero Miguel , Naves Javier , Lucena‐Perez María , Revilla Eloy 
Published: May 2024

AbstractConservation is prioritized based on accepted taxa. As a consequence, a conservation incentive exists to emphasize inter‐population differences to define taxa, potentially leading to taxonomic inflation. But stressing the uniqueness of threatened populations has the side effect of hindering conservation actions that promote inter‐population gene flow, such as genetic rescue. These actions may be of critical importance for severely inbred populations involved in extinction vortices, for which an inflated taxonomy can become a conservation trap. Here, we exemplify this scenario with the western capercaillie (Tetrao urogallus, Phasianidae) population in the Cantabrian Mountains, described and legally listed as a subspecies not supported by recent molecular data. The Cantabrian capercaillie population is Critically Endangered after a long‐lasting decline and a recent demographic collapse. It shows clear signs of inbreeding depression, including striking clutch size decreases as well as reduced hatchability and chick survival. This critical situation could be alleviated through a genetic rescue, but this possibility is hindered by inertias rooted in the putative uniqueness of the Cantabrian capercaillie. It had been previously argued that poor taxonomy could hamper conservation, through the oblivion of populations deserving, but not having, a taxonomic status. We show that taxonomic inflation can also become an obstacle for effective conservation.
Comparative imaging of septic navicular osteomyelitis caused by a solar penetration injury in a 15‐day‐old Shire foal
Authors: Bowkett‐Pritchard Constance , Baldwin Christopher M. 
Published: May 2024

SummaryA 15‐day‐old female Shire foal presented for acute lameness after sustaining a solar penetration injury, due to a nail, to the right hind sole 4 days previously. The foal was moderately lame at walk; all vital parameters were within normal limits. Clinical examination of the foot found a 2 mm long slit‐like defect in the plantar third of the lateral body of the frog. Radiographs revealed an ill‐defined rounded radiolucency within the navicular spongiosa that was surrounded by a halo of increased radiopacity. Transcuneal ultrasound corroborated the findings and found the navicular bone lesion to be closely associated with a hypoechogenic region within the lateral lobe of the deep digital flexor tendon (DDFT) all of which was continuous with a hypoechogenic tract extending from the sole. Computed tomographic examination confirmed a tract extending from the solar surface into the lateral portion of the navicular bone and confirmed a suspected impacted bone fragment. A diagnosis of septic navicular osteomyelitis and bursitis was made. The tract, navicular bone and DDFT were surgically debrided and navicular bursa lavage performed. The foal initially recovered well but navicular bursal sepsis recurred 6 days post‐operatively and the foal was euthanised. This report provides comprehensive comparative imaging of septic navicular osteomyelitis and bursitis secondary to a solar penetration in a 15‐day‐old foal and highlights the importance of different imaging modalities in case assessment and management.
Experimental investigations on the fatigue behavior of hybrid basalt/glass fiber epoxy composites
Authors: Agrawal Mayank , Durai Prabhakaran R. T. , Mahajan Puneet 
Published: May 2024

AbstractTo expand the applications of hybrid fiber composites in structural engineering applications, it is essential to study their fatigue behavior. The tensile and fatigue performance of unidirectional hybrid basalt/glass epoxy composites made with vacuum‐assisted resin infusion molding are investigated in this research. The sequencing influence on tensile properties was assessed using the two configurations of basalt/glass fiber epoxy hybrid fiber composites, namely GBBBG and BGBGB, having nearly equal volume fractions. According to the test results, hybrid fiber composites showed a positive hybrid effect on their tensile strength. Both hybrid layups showed higher tensile strengths (3.5% to 10.5%) than GFRPs and BFRPs. The GBBBG laminate has slightly higher fatigue resistance than BGBGB laminate under tension–tension (T–T) fatigue. Scanning electron microscopy (SEM) images verify the fatigue failure modes, which include fiber, matrix cracking, delamination, and debonding. The DMA analysis showed the lower adhesion efficiency of hybrid fiber composites, signifying lower damping properties.
Phytochemical profile, in vitro anti‐inflammatory, and anti‐xanthine oxidase activity of durian fruit rind fractions (Durio zibethinus)
Authors: Nguyen Thi Cam Vi , Huynh Thanh Tuyen , Huynh Thi Van An , Vo Ngoc Minh Thu , Le Hoai Oanh , Nguyen Thuy Thuy Trang , Le Ngoc Phuong Nghi , Dang Van‐Son , Tran Hoai Khang , Truong Dieu‐Hien , Barrow Colin J. , Nguyen Hoang Chinh 
Published: May 2024

SummaryDurian fruit rinds (Durio zibethinus) have increasingly attracted scientific interest due to their potent bioactive metabolites. In the present study, a comprehensive approach combining chromatographic techniques and bioassays was employed to elucidate the phytochemical constituents present in durian fruit rinds and their corresponding bioactivities. The crude ethanolic extract (CEE) and its fractions obtained through silica gel column chromatography (F1, F2, F3, and F4) were qualitatively and quantitatively analysed for their flavonoid profiles using thin‐layer chromatography, high‐performance liquid chromatography (HPLC), and liquid chromatography/mass spectrometry (LC/MS). Among the tested samples, fraction F2 exhibited the highest total flavonoid content (179.55 mg QE/g DW). TLC and HPLC analyses showed the presence of quercetin in all tested samples, with its content ranking in the order of F2 > F3 > F1 > F4 > CEE. The fractions exhibited inhibitory effects on albumin denaturation, protease activity, lipoxygenase (LOX), heat‐induced haemolysis, and xanthine oxidase (XO), surpassing those of the crude extract. These observed bioactivities correlated with the distribution of flavonoids and quercetin content in the samples. LC/MS analysis further showed the presence of flavonoids‐chalcone, flavonols, terpenoids, stilbene glycosides, anthocyanins, phenolics, and amino acids in fraction F2. These results determine the phytochemical profiles, anti‐inflammatory, and anti‐XO activities of bioactive fraction obtained from durian fruit rinds.
Welfare conditionality in Latin America's conditional cash transfers: Models and trends
Authors: Antía Florencia , Rossel Cecilia , Karsaclian Sofía 
Published: May 2024

AbstractTo what extent have Latin America's Conditional Cash Transfer (CCT) programs adopted different forms of conditionality? What are the main features of this variation, if any? In this article, we show that conditionalities vary across Latin America's CCTs and across time within programs. Drawing on existing conceptualizations of welfare conditionality and a novel, purpose‐built dataset covering 16 countries from 1997 to 2019, we analyze the evolution and variation in the design of welfare conditionality in the region. We find that conditionalities among Latin America's CCTs exhibit many different types and also vary significantly in how the program's main attributes—behavioral requirements, monitoring, and sanctioning rules—combine and evolve across time in each program. These combinations show that governments do not consistently produce “pure” CCT models but instead use conditionality features in many different ways and also adjust them over time, frequently to make more explicit what they expect from CCT recipients.
Older people's experiences of participation in mindfulness‐based intervention programmes: A qualitative systematic review
Authors: Hmwe Nant Thin Thin , Chan Chong Mei , Shayamalie Thalwaththe Gedara Nadeeka 
Published: May 2024

AbstractThis systematic review aimed to synthesise the qualitative evidence of mindfulness‐based interventions and focused on the perceptions and experience of older people. A literature search was conducted using electronic databases including CINAHL, EMBASE, EMCare, and MEDLINE. The inclusion criteria for the review were an original study that includes qualitative data on experience and perceptions of mindfulness interventions, a study population involving older people aged 60 years and above, and articles published in English. Eleven articles are included in this review. Four major descriptive themes were generated from the data synthesis: benefits on physical health, improved psychosocial well‐being, development of new perspectives, and motivators and challenges of mindfulness practice. Mindfulness practice provided health benefits for pain management, promoting sleep quality, psychosocial well‐being, and development of positive strategies such as a new way of coping in negative situations, acceptance, and a sense of freedom. Health benefits and positive reinforcement were reported as motivators, whereas time commitment and an easily distracted mind were barriers to continued mindfulness practice. In addition to the descriptive themes, two analytical themes were derived: inner peace and well‐being through mindfulness and development of acceptance‐based coping. The positive outcomes indicated in this review suggest that mindfulness‐based interventions could be an effective therapeutic tool for the well‐being of older people.
ODC and ROC Curves, Comparison Curves and Stochastic Dominance
Authors: Ledwina Teresa , Zagdański Adam 
Published: May 2024

SummaryWe discuss two novel approaches to inter‐distributional comparisons in the classical two‐sample problem. Our starting point is properly standardised and combined, very popular in several areas of statistics and data analysis, ordinal dominance and receiver characteristic curves, denoted by ODC and ROC, respectively. The proposed new curves are termed the comparison curves. Their estimates, being weighted rank processes on (0,1), form the basis of inference. These weighted processes are intuitive, well‐suited for visual inspection of data at hand and are also useful for constructing some formal inferential procedures. They can be applied to several variants of two‐sample problem. Their use can help improve some existing procedures both in terms of power and the ability to identify the sources of departures from the postulated model. To simplify interpretation of finite sample results, we restrict attention to values of the processes on a finite grid of points. This results in the so‐called bar plots (B‐plots), which readably summarise the information contained in the data. What is more, we show that B‐plots along with adjusted simultaneous acceptance regions provide principled information about where the model departs from the data. This leads to a framework that facilitates identification of regions with locally significant differences.We show an implementation of the considered techniques to a standard stochastic dominance testing problem. Some min‐type statistics are introduced and investigated. A simulation study compares two tests pertinent to the comparison curves to well‐established tests in the literature and demonstrates the strong and competitive performance of the former in many typical situations. Some real data applications illustrate simplicity and practical usefulness of the proposed approaches. A range of other applications of considered weighted processes is briefly discussed too.
Gender and sustainable entrepreneurship intention: Insights from Malaysian undergraduates
Authors: Latip Malisah , Yusuf Aidatul Ashya 
Published: May 2024

AbstractSustainable entrepreneurship is believed to be the solution to the detrimental impact of entrepreneurial activities. The concept underscores the necessity to discover, create and utilise business activities that positively contribute to environmental and societal sustainability. This article seeks evidence of which factors influence sustainable entrepreneurship intention (SEI) and how gender moderates the relationship among sustainability attitude, subjective norms and perceived behavioural control and SEI. The survey was administered to 390 undergraduate students at Malaysian public universities. By performing structural equation modelling analysis, results showed that SEI is influenced by sustainability attitude and perceived behavioural control, whereas subjective norms do not have such an impact. The moderation analysis further discovered that gender only moderates the relationship between sustainable attitude and SEI; the strength of the relationship is stronger among female students. The results of this study offer practical guidance for policymakers and industry stakeholders. Policymakers can use these findings to craft focused initiatives and educational programmes to nurture sustainable entrepreneurship among students, cultivating a future workforce dedicated to ethical business conduct. Industry leaders can draw on the understanding of gender differences in the link between sustainability attitudes and SEI to formulate strategies for attracting and retaining talent inclined towards sustainable practices in their entrepreneurial pursuits.
Esthetic outcomes in orthodontics through digital customization with a lingual appliance system
Authors: Weissheimer Andre , Pham John , Tong Hongsheng , Akyalcin Sercan 
Published: May 2024

AbstractBackgroundContemporary fixed orthodontic appliances are shifting from non‐customized pre‐adjusted appliances to custom‐designed and printed appliances with novel digital setup systems. We are one step closer to precision dentistry and orthodontics using personalized mechanics and custom appliances. However, despite the evidential enhancement and other improvements to fixed appliances, tooth movement is still limited to five degrees of freedom. Opening or closing spaces still requires manually placing elastomeric chains or coil springs.AimIn this article, we aimed to demonstrate how advancements in CAD/CAM technology, reverse engineering, and digital customization are helping orthodontics constantly evolve, enabling treatment with enhanced esthetics and minimal compliance. The clinical system (InBrace®, Irvine, CA) described in this article uses a patient‐specific, digitally designed multiloop NITI wire that delivers friction‐free, light, and continuous forces and activates automatically whenever the malocclusion deviates from the digital setup.ConclusionThrough digital customization, InBrace allows for automated tooth movement in all six degrees of freedom, including space opening or closure, via programmed non‐sliding mechanics.Clinical SignificancePrecision orthodontics and personalized treatment have been significant developments in orthodontics recently. This article focuses on how a technologically advanced lingual appliance system could achieve targeted cosmetic results methodically via automation and personalization.
Surface roughness and optical characteristics evaluations after chairside adjustment of different zirconia types
Authors: Abdulmajeed Awab , Sulaiman Taiseer A. , Suliman Abdulhaq A. , Abdulmajeed Aous A. , Närhi Timo O. 
Published: May 2024

AbstractStatement of ProblemLimited evidence is available for the effect of chairside adjustment using rotary cutting instruments on the surface roughness and optical properties of different zirconia types.PurposeTo evaluate the effect of simulated adjustments on surface roughness and optical properties of different zirconia types.Materials and MethodsThree Partially Stabilized Zirconia (PSZ) types based on mole percent yttria (Y) concentration from the same manufacturer (Katana; Kuraray) were used: 3Y‐PSZ, 4Y‐PSZ, and 5Y‐PSZ. Thirty disk‐shaped specimens (Ø14 × 1.2 mm) from different zirconia types (N = 90) were prepared. Specimens were either left without adjustment (NA), adjusted with Dialite ZR finishing and polishing system (Brasseler) (APol), or adjusted with course diamond instruments only (ADia). The specimens were distributed into 9 groups (n = 10): Group 3Y‐PSZ/NA, Group 3Y‐PSZ/APol, Group 3Y‐PSZ/ADia, Group 4Y‐PSZ/NA, Group 4Y‐PSZ/APol, Group 4Y‐PSZ/ADia, Group 5Y‐PSZ/NA, Group 5Y‐PSZ/APol, and Group 5Y‐PSZ/ADia. The surface roughness of specimen was analyzed using an Atomic Force Microscope (AFM) (Bruker's Dimension Icon, Bruker) and Root Means Square (RMS) were recorded (nm). Surface Gloss (SG), Translucency Parameter (TP), and Contrast Ratio (CR) values of all groups were recorded using an integrating sphere spectrophotometer. Statistical analysis was performed using analysis of variance (ANOVA) and Tukey's multiple comparison tests for pairwise comparisons at p < 0.05 and 95% confidence interval.ResultsAPol had no effect on the surface roughness (p = 0.88) while ADia had a significant negative effect (p < 0.05) despite the type of zirconia. Out of the three testes optical properties, only SG was negatively affected by ADia for all types of zirconia (p < 0.05). The two adjustment types did not affect the TP of all the tested zirconia (p = 0.91). The CR was not affected by the tested adjustments for all zirconia types (p = 0.726).ConclusionProper zirconia adjustment following a sequence of burs and polishers can maintain acceptable roughness and optical properties. Adjustment of zirconia with rough diamond can lead to deleterious effects and should be avoided.Clinical SignificanceChairside adjustment of zirconia could lead to rougher surface and unpredictable changes of surface gloss. Therefore, zirconia adjustment should be minimized to the greatest extent possible and a proper protocol should be followed if had to be done.
Assessment of dental and periodontal indices and Streptococcus mutans virulence in fragile X syndrome patients
Authors: do Amaral Cristhiane Olivia Ferreira , Kantovitiz Kamila Rosamilia , de Araújo V. C. , Marega T. , Teixeira L. N. , Martinez E. F. 
Published: May 2024

AbstractIntroductionFragile X syndrome (FXS) is the most common cause of hereditary genetic disorder in a single gene characterised by intellectual disability. Behavioural features such as autism, hyperactivity and anxiety disorder may be present. Biofilm development and pathogenicity of Streptococcus mutans may be altered because FXS renders the dental approach and oral hygiene more complex.ObjectivesThe purpose of this study was to compare the levels of transcripts for VicRK and CovR of S. mutans isolated from FXS patients with the levels of transcripts for VicRK and CovR of standard strain ATCC, using a quantitative polymerase chain reaction (qPCR).MethodsThe caries experience index was assessed by the International Caries Detection and Assessment System (ICDAS), Periodontal Condition Index (PCI) and Invasive Dental Treatment Need Index (INI).ResultsThe clinical index findings revealed a high rate of caries cavities and bleeding on probing of FXS patients. When VicRK and CovR transcript levels were compared with the reference strain, Fragile X patients were found to have significantly higher values.ConclusionThe present study demonstrated that FXS patients have more adverse clinical conditions, with increased biofilm accumulation and virulence. When combined with behavioural abnormalities, these patients become even more vulnerable to dental caries.