bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prognostic impact of discordant results from cytogenetics and flow cytometry in patients with acute myeloid leukemia undergoing hematopoietic cell transplantation
Authors: Fang Min , Storer Barry , Wood Brent , Gyurkocza Boglarka , Sandmaier Brenda M. , Appelbaum Frederick R. 
Published: September 2011

AbstractBACKGROUND:Cytogenetics and multicolor flow cytometry (MFC) are useful tools for monitoring outcome of treatment in acute myeloid leukemia (AML). However, no data are available regarding the meaning of results when the 2 tests do not agree.METHODS:The authors of this report analyzed 1464 pairs of concurrent cytogenetics and flow results from 424 patients, before and after hematopoietic cell transplantation, and compared the prognostic impact of discordant and concordant results.RESULTS:Informative discordant results were observed in 22% of patients. Compared with patients who had double‐negative test results, either positive result had a significant impact on overall survival and relapse‐free survival. The hazard ratios with either positive cytogenetic results or positive MFC results pretransplantation were 3.1 (P = .009) and 2.5 (P = .0008), respectively, for reduced overall survival and 2.7 (P = .01) and 4.1 (P < .0001), respectively, for decreased recurrence‐free survival. Similar findings were obtained post‐transplantation. Molecular cytogenetics, ie, fluorescence in situ hybridization (FISH), added value to the evaluation of discordant cases.CONCLUSIONS:The detection of residual AML by either cytogenetics or flow cytometry in patients who underwent hematopoietic cell transplantation predicted early relapse and shortened survival. Cancer 2012;. © 2011 American Cancer Society.
Progress and Challenges in the Calculation of Electronic Excited States
Authors: González Leticia , Escudero Daniel , Serrano‐Andrés Luis 
Published: September 2011

AbstractA detailed understanding of the properties of electronic excited states and the reaction mechanisms that molecules undergo after light irradiation is a fundamental ingredient for following light‐driven natural processes and for designing novel photonic materials. The aim of this review is to present an overview of the ab initio quantum chemical and time‐dependent density functional theory methods that can be used to model spectroscopy and photochemistry in molecular systems. The applicability and limitations of the different methods as well as the main frontiers are discussed. To illustrate the progress achieved by excited‐state chemistry in the recent years as well as the main challenges facing computational chemistry, three main applications that reflect the authors’ experience are addressed: the UV/Vis spectroscopy of organic molecules, the assignment of absorption and emission bands of organometallic complexes, and finally, the obtainment of non‐adiabatic photoinduced pathways mediated by conical intersections. In the latter case, special emphasis is put on the photochemistry of DNA. These applications show that the description of electronically excited states is a rewarding but challenging area of research.
3D Amino‐Induced Electroless Plating: A Powerful Toolset for Localized Metallization on Polymer Substrates
Authors: Garcia Alexandre , Berthelot Thomas , Viel Pascal , Jégou Pascale , Palacin Serge 
Published: September 2011

AbstractThe “3D amino‐induced electroless plating” (3D‐AIEP) process is an easy and cost‐effective way to produce metallic patterns onto flexible polymer substrates with a micrometric resolution and based on the direct printing of the mask with a commercial printer. Its effectiveness is based on the covalent grafting onto substrates of a 3D polymer layer which presents the ability to entrap Pd species. Therefore, this activated Pd‐loaded and 3D polymer layer acts both as a seed layer for electroless metal growth and as an interdigital layer for enhanced mechanical properties of the metallic patterns. Consequently, flexible and transparent poly(ethylene terephtalate) (PET) sheets were selectively metalized with nickel or copper patterns. The electrical properties of the obtained metallic patterns were also studied.
Combination of MOFs and Zeolites for Mixed‐Matrix Membranes
Authors: Zornoza Beatriz , Seoane Beatriz , Zamaro Juan M. , Téllez Carlos , Coronas Joaquín 
Published: September 2011

AbstractMixed‐matrix membranes (MMMs) were prepared by combinations of two different kinds of porous fillers [metal‐organic frameworks (MOFs) HKUST‐1 and ZIF‐8, and zeolite silicalite‐1] and polysulfone. In the search for filler synergy, the MMMs were applied to the separation of CO2/N2, CO2/CH4, O2/N2, and H2/CH4 mixtures and we found important selectivity improvements with the HKUST‐1‐silicalite‐1 system (CO2/CH4 and CO2/N2 separation factors of 22.4 and 38.0 with CO2 permeabilities of 8.9 and 8.4 Barrer, respectively).
Carbon Dioxide Recycling: Emerging Large‐Scale Technologies with Industrial Potential
Authors: Quadrelli Elsje Alessandra , Centi Gabriele , Duplan Jean‐Luc , Perathoner Siglinda 
Published: September 2011

AbstractThis Review introduces this special issue of ChemSusChem dedicated to CO2 recycling. Its aim is to offer an up‐to‐date overview of CO2 chemical utilization (inorganic mineralization, organic carboxylation, reduction reactions, and biochemical conversion), as a continuation and extension of earlier books and reviews on this topic, but with a specific focus on large‐volume routes and projects/pilot plants that are currently emerging at (pre‐)industrial level. The Review also highlights how some of these routes will offer a valuable opportunity to introduce renewable energy into the existing energy and chemical infrastructure (i.e., “drop‐in” renewable energy) by synthesis of chemicals from CO2 that are easy to transport and store. CO2 conversion therefore has the potential to become a key pillar of the sustainable and resource‐efficient production of chemicals and energy from renewables.
Synthesis and Structural Characterization of Palladacycles with Polydentate Ligands by a Stepwise Coupling Route – Palladacycles Containing Halides as Efficient Catalysts and Substrates
Authors: Xu Chen , Wang Zhi‐Qiang , Zhang Ya‐Peng , Dong Xin‐Ming , Hao Xin‐Qi , Fu Wei‐Jun , Ji Bao‐Ming , Song Mao‐Ping 
Published: September 2011

AbstractA series of ferrocenyl palladacycles with polydentate ligands were conveniently prepared by the Suzuki coupling reactions of a halide‐containing ferrocenyl palladacycle [PdCl({(η5‐C5H5)}Fe{(η5‐C5H3)N2C4H2Cl})(PPh3)] (1) andarylboronic acids without additional palladium catalysis. In the absence of additional base, amination also occurred in high yield. This new protocol was successfully applied to the Suzuki coupling reactions of the analogous halide‐containing palladacycle [PdCl({(η5‐C5H5)}Fe{(η5‐C5H3)NC5H3Br})(PPh3)] (15) and Buchwald–Hartwig amination of the analogous complex [PdCl({(η5‐C5H5)}Fe{(η5‐C5H3)NC5H3Br})(DCPAB)] (32), where DCPAB = 2‐dicyclohexylphosphanyl‐2′‐(N,N‐dimethylamino)biphenyl. The halide‐containing palladacycles act as efficient catalysts and substrates in the coupling reactions. 37 new examples have been fully characterized by elemental analysis, IR and 1H NMR spectroscopy, and ESI‐MS. Additionally, the molecular structures of eight compounds were determined by single‐crystal X‐ray diffraction, and many types of intermolecular C–H···Cl (O, N, π) interactions and π–π interactions were found in the crystal structures of these palladacycles.
Preparation of Calix[8]arene Derivatives Functionalized at a Single Methylene Bridge
Authors: Itzhak Norbert , Kogan Katerina , Biali Silvio E. 
Published: September 2011

AbstractA calix[8]arene derivative substituted at the single methylene bridge by a chlorine atom reacts at the substituted bridge with O, N, and C nucleophiles under SN1 conditions. Thiscalix[8]arene can serve as a useful starting material for the preparation of calix[8]arene derivatives functionalized at a single methylene bridge.
Reduced fronto‐callosal fiber integrity in unmedicated OCD patients: A diffusion tractography study
Authors: Oh Jungsu S. , Jang Joon Hwan , Jung Wi Hoon , Kang Do‐Hyung , Choi Jung‐Seok , Choi Chi‐Hoon , Kubicki Marek , Shenton Martha E. , Kwon Jun Soo 
Published: September 2011

AbstractIt is widely accepted that abnormalities in the frontal area of the brain underpin the pathophysiology of obsessive‐compulsive disorder (OCD). Fundamental to this investigation is the delineation of frontal white matter tracts including dorsal and ventral frontal projections of interhemispheric connections. While previous investigations of OCD have examined the dorsal and ventral frontal regions, the corresponding callosal connections have not been investigated, despite their importance. We recruited twenty patients with OCD (15 drug‐naïve and 5 currently unmedicated) and demographically similar healthy controls, and conducted fiber tractography and post hoc quantitative analysis using diffusion tensor imaging. We extracted fractional anisotropy (FA) of the fronto‐callosal fibers along the entire length of the tract. Function‐specific [by the Brodmann area region‐of‐interest (ROI) approach] and region‐specific (by the length‐parameterization approach) tracts were defined. In addition, we devised a new index of dorsal‐ventral imbalance (DVII) of fiber integrity. Significant FA decreases were observed in orbitofrontal and dorsolateral prefrontal projections of the corpus callosum (P < 0.05, false discovery rate‐corrected) with higher function/region sensitivity than voxel‐based or ROI‐based approaches. Importantly, OCD patients also exhibited significantly higher ventral‐greater‐than‐dorsal asymmetry of FA values than normal controls (P < 0.05, FDR‐corrected). This study is the first to investigate fiber integrity in the dorsal/ventral frontal parts of the callosal tractography in unmedicated OCD patients. Using a more quantitative method in terms of functional and regional specificity than previous studies, we report abnormalities in interhemispheric connectivity of both dorsal and ventral networks in the pathophysiology of OCD. Hum Brain Mapp 33:2441–2452, 2012. © 2011 Wiley Periodicals, Inc.
Water storage in a till catchment. I: Distributed modelling and relationship to runoff
Authors: Seibert Jan , Bishop Kevin , Nyberg Lars , Rodhe Allan 
Published: September 2011

AbstractAlthough water storage is an important variable to understand the hydrological functioning of a catchment, it is challenging to estimate the total water storage in a catchment. Catchment water storage can be estimated on the basis of water balance, but this approach is prone to errors in the different water balance terms. Here, an approach is presented to estimate the daily dynamics of catchment‐wide soil water and groundwater storage on the basis of groundwater‐level observations, soil properties and an assumption of hydrological equilibrium above the water table. This approach was applied to a 6300‐m2 till catchment in Southwest Sweden. The predicted mean catchment water storage between April 1991 and June 1992 was 210 mm and ranged from 190 to 260 mm. The estimated water storage followed runoff rates closely especially during recession periods. On average, 79% of the water storage was held in the unsaturated zone, and the remaining 21% was groundwater, but this proportion varied strongly with runoff and total storage. During dry conditions, unsaturated storage accounted for at maximum 95% of the water storage; during wet conditions, this number dropped to 40%. Copyright © 2011 John Wiley & Sons, Ltd.
CCN2 promotes cigarette smoke‐induced proliferation of rat pulmonary artery smooth muscle cells through upregulating cyclin D1 expression
Authors: Wang Ran , Xu Yong‐jian , Liu Xian‐sheng , Zeng Da‐xiong , Xiang Min 
Published: September 2011

AbstractCigarette smoke has been demonstrated to induce pulmonary vascular remodeling, which is characterized by medial thickening of the pulmonary arteries mainly resulting from the abnormal proliferation of pulmonary artery smooth muscle cells (PASMCs). However, the molecular mechanism underlying this process is still unclear. In the present study, we investigated whether CCN2 regulated rat PASMCs (rPASMCs) proliferation induced by cigarette smoke extract (CSE) and nicotine by upregulating cyclin D1 in vitro. CCN2 siRNA or cyclin D1 siRNA were transfected to rPASMCs which were then exposed to CSE and nicotine. Both mRNA and protein expressions of CCN2 were significantly increased in rPASMCs treated with 2% CSE or 1 µM nicotine, which markedly promoted the proliferation of rPASMCs. CCN2 siRNA inhibited the proliferation of rPASMCs induced by CSE or nicotine. Furthermore, CCN2 siRNA markedly suppressed the mRNA and protein expressions of cyclin D1 in rPASMCs and led to cell cycle arrest in G0/G1 phase resulting in reduced rPASMCs proliferation. These findings suggest that CCN2 contributes to the CSE and nicotine‐induced proliferation of rPASMCs at least in part by upregulating cyclin D1 expression. J. Cell. Biochem. 113: 349–359, 2012. © 2011 Wiley Periodicals, Inc.
Nemo‐like kinase inhibits osteoblastogenesis by suppressing bone morphogenetic protein and WNT canonical signaling
Authors: Zanotti Stefano , Canalis Ernesto 
Published: September 2011

AbstractThe bone morphogenetic protein/Signaling mothers against decapentaplegic (BMP/Smad) and the WNT signaling pathways regulate the commitment of mesenchymal cells to the osteoblastic lineage. Nemo‐like kinase (Nlk) is an evolutionary conserved kinase that suppresses Smad transactivation and WNT canonical signaling. However, it is not clear whether these effects of Nlk have any consequence on the differentiation of mammalian cells. To study the function of Nlk during the commitment of ST‐2 bone marrow stromal cells to the osteoblastic fate, Nlk was downregulated by RNA interference (RNAi), following transfection of a specific small interfering (si)RNA. Nlk downregulation increased alkaline phosphatase and osteocalcin expression and sensitized ST‐2 cells to the effects of BMP2 and WNT3 on alkaline phosphatase mRNA expression and activity. Accordingly, Nlk downregulation enhanced the effect of BMP2 on the transactivation of the BMP/Smad reporter construct 12xSBE‐Oc‐pGL3, and on the levels of phosphorylated Smad1/5/8, whereas it did not affect the transactivation of the transforming growth factor‐β/Smad reporter pSBE‐Luc. Nlk downregulation sensitized ST‐2 cells to the effects of WNT3 on the transactivation of the WNT/T‐cell factor (Tcf) reporter construct 16xTCF‐Luc, whereas it did not affect cytosolic β‐catenin levels. To understand the function of Nlk in cells committed to the osteoblastic lineage, Nlk was suppressed by RNAi in primary calvarial osteoblasts. Downregulation of Nlk increased alkaline phosphatase and osteocalcin transcripts and sensitized osteoblasts to the effects of BMP2 on alkaline phosphatase activity and Smad1/5/8 transactivation and phosphorylation. In conclusion, Nlk suppresses osteoblastogenesis by opposing BMP/Smad and WNT canonical signaling. J. Cell. Biochem. 113: 449–456, 2012. © 2011 Wiley Periodicals, Inc.
Near‐to‐perfect homeostasis: Examples of universal aging rule which germline evades
Authors: Teplyuk Nadiya M. 
Published: September 2011

AbstractAging is considered to be a progressive decline in an organism's functioning over time and is almost universal throughout the living world. Currently, many different aging mechanisms have been reported at all levels of biological organization, with a variety of biochemical, metabolic, and genetic pathways involved. Some of these mechanisms are common across species, and others work different, but each of them is constitutive. This review describes the common characteristics of the aging processes, which are consistent changes over time that involve either the accumulation or depletion of particular system components. These accumulations and depletions may result from imperfect homeostasis, which is the incomplete compensation of a particular biological process with another process evolved to compensate it. In accordance with disposable‐soma theory, this imperfection in homeostasis may originate as a function of cell differentiation as early as in yeasts. It may result either from antagonistic pleiotropy mechanisms, or be simply negligible as a subject of natural selection if an adverse effect of the accumulation phenotypically manifests in organism's post‐reproductive age. If this phenomenon holds true for many different functions it would lead to the occurrence of a wide variety of aging mechanisms, some of which are common among species, while others unique, because aging is the inherent property of most biological processes that have not yet evolved to be perfectly in balance. Examples of imperfect homeostasis mechanisms of aging, the ways in which germ line escapes from them, and the possibilities of anti‐aging treatment are discussed in this review. J. Cell. Biochem. 113: 388–396, 2012. © 2011 Wiley Periodicals, Inc.
Confirmatory factor and measurement invariance analyses of the emotion regulation questionnaire
Authors: Melka Stephen E. , Lancaster Steven L. , Bryant Andrew R. , Rodriguez Benjamin F. 
Published: September 2011

AbstractEmotion regulation is widely studied in many areas of psychology and the number of publications on emotion regulation has increased exponentially over the past few decades. Additionally, interest in the relationships between emotion dysregulation processes and psychopathology has drastically increased in recent years. The Emotion Regulation Questionnaire (ERQ) was developed to measure two specific constructs related to emotion control: reappraisal and suppression (Gross & John, 2003). In its initial validation study and subsequent analyses, the instrument was shown to possess sound psychometric properties, but, to date, inquiry regarding the measure's characteristics has been limited. Factor analytic examinations of commonly used instruments are recommended to validate the properties of a given measure and increase researchers understanding of the measured constructs. The current study examined the psychometric properties of the ERQ in a sample of 1,188 undergraduates through confirmatory factor analysis. Additionally, tests of measurement invariance were employed in order to examine potential structural differences based on gender and ethnicity. The current study supported the original structure of the measure with all demographic groups and exceptional fit was demonstrated. Additional normative data for gender and ethnic groups are included. Results support the use of the instrument in future research. © 2011 Wiley Periodicals, Inc. J Clin Psychol: In Session 67:1–11, 2011.
Telocyte morphologies and potential roles in diseases
Authors: Zheng Yonghua , Bai Chunxue , Wang Xiangdong 
Published: September 2011

AbstractTelocytes (TCs) are a new type of interstitial cells, a small cellular body with the presence of 2–5 prolongations named as telopode (Tp)‐very thin (less than 0.2 µm) and extremely long (10–1,000 µm), a moniliform aspect, and caveolae, containing a nucleus surrounded by a small amount of cytoplasm. The nucleus occupies about 25% of TC body volume and contains clusters of heterochromatin attached to the nuclear envelope. The perinuclear cytoplasm is rich in mitochondria and contains a small Golgi complex, rough and smooth endoplasmic reticulum and cytoskeletal elements. TCs have several immunophenotypes such as CD34, c‐kit, and vimentin. TCs were found in many organs of mammals with potential biological functions, even though the exact function remains unclear. Recently, we identified and isolated TCs from the trachea for the first time and confirmed the existence of TC in lung tissues, which could have the potential significance in the pathogenesis of pulmonary diseases. Future efforts are required to clarify pathophysiological functions of TCs in the disease. J. Cell. Physiol. 227: 2311–2317, 2012. © 2011 Wiley Periodicals, Inc.
Diffusion‐weighted magnetic resonance imaging in the detection of testicular torsion: Feasibility study
Authors: Maki Daisuke , Watanabe Yuji , Nagayama Masako , Ishimori Takayoshi , Okumura Akira , Amoh Yoshiki , Nakashita Satoru , Terai Akihito , Dodo Yoshihiro 
Published: September 2011

AbstractPurpose:To investigate the feasibility and usefulness of diffusion‐weighted magnetic resonance imaging in the detection of testicular torsion.Materials and Methods:Institutional Review Board approval and informed consent from all participants were obtained. Consecutive 28 patients with acute scrotal symptoms were included in this study. Fat‐suppressed T2‐weighted, dynamic subtraction contrast‐enhanced, and diffusion‐weighted images were obtained in the coronal plane with a 1.5 T MR unit. An apparent diffusion coefficient (ADC) map was reconstructed from the diffusion‐weighted images obtained with b‐factor of 0 and 800 s/mm2. Comparisons of ADC values between the affected and nonaffected testes were performed with Mann–Whitney's U‐test.Results:Diffusion‐weighted and ADC images with diagnostic quality were obtained in 23 out of the 28 patients (82%). In testicular torsion (n = 9), the mean ADC value of the twisted testes was significantly lower than that of the nonaffected testes (0.750 ± 0.297 vs. 1.017 ± 0.165 × 10−3 mm2/sec, P < 0.05). In other scrotal disorders (n = 14), there was no significant difference in the mean ADC value of the testes between the affected and nonaffected side (P = 0.655). The affected‐to‐nonaffected ratio of ADC value was significantly lower in testicular torsion than that in other scrotal disorders (P < 0.05).Conclusion:Diffusion‐weighted imaging of the scrotum with testicular ADC measurement can allow for the detection of testicular torsion without any use of contrast media. J. Magn. Reson. Imaging 2011;. © 2011 Wiley Periodicals, Inc.
Association of placental volume measured by MRI and birth weight percentile
Authors: Derwig Iris E. , Akolekar Ranjit , Zelaya Fernando O. , Gowland Penny A. , Barker Gareth J. , Nicolaides Kypros H. 
Published: September 2011

AbstractPurpose:To investigate if placental volume in the second trimester of pregnancy is related to uterine artery blood flow and neonatal birth weight.Materials and Methods:In 83 singleton pregnancies at 24–29 weeks' gestation, uterine artery pulsatility index (PI) was measured by Doppler ultrasound and placental volume was calculated from images obtained by magnetic resonance imaging (MRI) at 1.5T. The significance of the association between placental volume, uterine artery PI, and birth weight was examined.Results:In 37 normal pregnancies resulting in delivery of neonates with birth weight at or above the 10th percentile, the median placental volume increased with gestational age from 363 cm3 at 24 weeks to 515 cm3 at 29 weeks. In 46 pregnancies that resulted in delivery of small for gestational age (SGA) neonates with birth weight below the 10th percentile the median placental volume, corrected for gestational age, was significantly decreased by 120 cm3 (P < 0.0001) and median uterine artery PI was increased (1.87 vs. 1.59, P < 0.0001). There were significant associations between placental volume and both uterine artery PI (r = −0.677, P < 0.0001) and birth weight percentile (r = 0.658, P < 0.0001).Conclusion:Placental volume during the second trimester is smaller in pregnancies that subsequently deliver SGA neonates and the measurement is related to placental perfusion. J. Magn. Reson. Imaging 2011;. © 2011 Wiley Periodicals, Inc.