bluuebunny/crossref_metadata_2025_split huggingface dataset:
Optimizing the outcome of surgery in patients with rectal cancer and synchronous liver metastases
Authors: van der Pool A E , de Wilt J H , Lalmahomed Z S , Eggermont A M , IJzermans J N , Verhoef C 
Published: January 2010

Abstract

Background
This study evaluated the outcome of patients treated for rectal cancer and synchronous hepatic metastases in the era of effective induction radiotherapy and chemotherapy.

Methods
All patients undergoing surgical treatment of rectal cancer and synchronous liver metastases between 2000 and 2007 were identified retrospectively from a prospectively collected database. Three approaches were followed: the classical staged, the simultaneous and the liver-first approach.

Results
Of 57 patients identified, the primary tumour was resected first in 29 patients (group 1), simultaneous resection was performed in eight patients (group 2), and 20 patients underwent a liver-first approach (group 3). The overall morbidity rate was 24·6 per cent; there was no in-hospital mortality. Median in-hospital stay was significantly shorter for the simultaneous approach (9 days versus 18 and 15 days for groups 1 and 3 respectively; P &lt; 0·001). The overall 5-year survival rate was 38 per cent, with an estimated median survival of 47 months.

Conclusion
Long-term survival can be achieved using an individualized approach, with curative intent, in patients with rectal cancer and synchronous liver metastases. Simultaneous resections as well as the liver-first approach are attractive alternatives to traditional staged resections.
Randomized clinical trial to compare the effects of preoperative oral carbohydrate versus placebo on insulin resistance after colorectal surgery
Authors: Wang Z G , Wang Q , Wang W J , Qin H L 
Published: January 2010

Abstract

Background
Preoperative oral carbohydrate (OCH) reduces postoperative insulin resistance (PIR). This randomized trial investigated whether this effect is related to insulin-induced activation of the phosphatidylinositol 3-kinase (PI3K)/protein kinase B (PKB) signalling pathway.

Methods
Patients with colorectal cancer scheduled for elective open resection were randomly assigned to preoperative OCH, fasting or placebo. Preoperative general well-being, insulin resistance before and immediately after surgery, and postoperative expression of PI3K, PKB, protein tyrosine kinase (PTK) and glucose transporter 4 (GLUT4) in rectus abdominis muscle were evaluated.

Results
Patient and operative characteristics did not differ between groups. Subjective well-being was significantly better in OCH and placebo groups than in the fasting group, primarily because of reduced thirst (P = 0·005) and hunger (P = 0·041). PIR was significantly greater in fasting and placebo groups (P &lt; 0·010). By the end of surgery, muscle PTK activity as well as PI3K and PKB levels were significantly increased in the OCH group compared with values in fasting and placebo groups (P &lt; 0·050), but GLUT4 expression was unaffected.

Conclusion
PIR involves the PI3K/PKB signalling pathway. Preoperative OCH intake improves preoperative subjective feelings of hunger and thirst compared with fasting, while attenuating PIR by stimulation of the PI3K/PKB pathway. Registration number: NCT00755729 (http://www.clinicaltrials.gov).
Inter‐rater reliability of the PCL‐R total and factor scores among psychopathic sex offenders: are personality features more prone to disagreement than behavioral features?
Authors: Edens John F. , Boccaccini Marcus T. , Johnson Darryl W. 
Published: January 2010

AbstractDespite considerable support for the inter‐rater reliability of the Hare Psychopathy Checklist—Revised (PCL‐R; Hare, 1991, 2003) in research contexts, there is increasing concern that scores from this instrument may be considerably less stable across examiners in applied contexts, particularly when scoring is based on separate interviews. The present study examines archival data from a sample of imprisoned sex offenders (n = 20) who obtained relatively high PCL‐R total scores (≥25) and were administered this instrument on a second occasion by a different examiner. Intraclass correlations for the total and Factor 2 score were lower than those generally reported in research studies. Of greater concern, Factor 1 scores were only negligibly related to each other (ICCA,1 = .16). Correcting for potential range restriction among these high scoring individuals resulted in total and Factor 2 score measures of agreement that were somewhat more consistent with published research, but Factor 1 continued to display exceedingly poor agreement across examiners. Copyright © 2010 John Wiley & Sons, Ltd.
Assessing risk of sexually abusive behavior among youth in a child welfare sample
Authors: Prentky Robert A. , Li Nien‐Chen , Righthand Sue , Schuler Ann , Cavanaugh Deborah , Lee Austin F. 
Published: January 2010

AbstractStatutory management of juvenile sexual offenders demands reliable, valid methods for assessing the risk posed by these youth. This study examined the predictive validity of the J‐SOAP‐II using samples of adolescent and pre‐adolescent boys who were wards of the Massachusetts Department of Social Services. The base rate for sexual recidivism among the adolescents (14–16%) is generally in line with what has been reported. The equivalent base rate for the pre‐adolescents (25–28%), however, was notably higher. Although the J‐SOAP‐II was developed for adolescents, the scale also worked with the pre‐adolescents in predicting sexual recidivism over 7 years, with AUC values of 0.77, 0.74, 0.77, and 0.80 for Scales 1, 3, 4, and Total among the pre‐adolescents and AUC values of 0.80, 0.82, and 0.83 for Scales 1, 4, and Total among the adolescents. Discussion focuses on extant J‐SOAP research and sample dependent variability, as well as social policy implications. Copyright © 2010 John Wiley & Sons, Ltd.
Psychological mechanisms underlying support for juvenile sex offender registry laws: prototypes, moral outrage, and perceived threat
Authors: Salerno Jessica M. , Najdowski Cynthia J. , Stevenson Margaret C. , Wiley Tisha R. A. , Bottoms Bette L. , Vaca Roberto , Pimentel Pamela S. 
Published: January 2010

AbstractIn three studies, we investigated support for applying sex offender registry laws to juveniles. Family law attorneys supported registry laws less for juveniles than for adults. Laypeople and prosecutors supported juvenile and adult sex offender registration equally—even though they perceived juveniles as generally less threatening than adults (Study 1)—because most people spontaneously envision a severe sex offender prototype regardless of offender age (Study 2). People are less supportive of registry laws, however, when they envision less severe prototypes spontaneously (Study 2) or when induced to do so (Study 3). Effects of offender age, offender prototypes, and offense severity were mediated by perceptions of threat posed by the juvenile sex offender (i.e., utilitarian concerns). The effect of offense severity was also mediated by moral outrage (i.e., retributive concerns). Copyright © 2010 John Wiley & Sons, Ltd.
Transcatheter aortic valve implantation through the left subclavian artery with a patent LIMA graft
Authors: Taramasso Maurizio , Giacomini Andrea , Maisano Francesco 
Published: January 2010

AbstractWe report the case of an 80‐year‐old male with severe aortic valve stenosis previously submitted to surgical myocardial revascularization with patent mammary graft treated by TAVI through left‐transaxillary approach because of unsuitable transfemoral and transapical approaches.© 2010 Wiley‐Liss, Inc.
Comparison of door‐to‐balloon times for primary PCI using transradial versus transfemoral approach
Authors: Pancholy Samir , Patel Tanuj , Sanghvi Kintur , Thomas Marie , Patel Tejas 
Published: January 2010

AbstractObjectives: The objective of this study was to compare door‐to‐balloon times and other variables in ST‐segment elevation myocardial infarction (STEMI) patients undergoing primary percutaneous coronary intervention (PCI) using transfemoral or transradial approaches. Background: Transradial PCI has been shown to lower the risk of access site complications but the procedure is not applied to STEMI patients, due to concerns of procedural complexity adversely affecting prompt reperfusion. There is paucity of real‐world data comparing TRI with TFI in patients with STEMI. Methods: Three hundred sixteen consecutive patients with STEMI undergoing primary PCI were studied. Patients were divided in two groups, Group I (n = 204) undergoing PCI transfemorally and Group II (n = 109) patients transradially. Demographic data, door‐to‐balloon times, procedural variables, predischarge adverse events, access site complications, and 1 year follow‐up major adverse cardiac events (MACE) were recorded. Results: Door‐to‐balloon time was 72 ± 14 min in Group I compared with 70 ± 17 min in Group II, the difference was not statistically significant (t = 1.096, P > 0.27). Group II patients had significantly fewer access site complications compared with Group I (20 vs. 1 patient, χ2 = 10.8, P < 0.05). Demographics, predischarge adverse events, and MACE at 1 year follow‐up were comparable between the two groups. Conclusions: Transradial approach to primary PCI provides similar door‐to‐balloon times to transfemoral approach, and significantly lowers access site related complications, in patients presenting with STEMI. © 2010 Wiley‐Liss, Inc.
ViewIT improves intravascular ultrasound‐guided wiring in coronary intervention of chronic total occlusion
Authors: Okamura Atsunori , Iwakura Katsuomi , Fujii Kenshi 
Published: January 2010

AbstractTerumo intravascular ultrasound (IVUS) ViewIT facilitates IVUS‐guided wiring in percutaneous coronary intervention (PCI) for chronic total occlusion (CTO) due to its low profile and surface coating. In PCI for CTO, the first guidewire is sometimes inserted into the subintimal space, and observation by IVUS through the first guidewire in the subintima can allow the second guidewire to be led visually into the true lumen. We describe a case of CTO in which ViewIT was inserted into the subintimal space of the CTO lesion and scanning from the coronary ostium to the CTO subintimal space allowed the second guidewire to be led into the true lumen. © 2010 Wiley‐Liss, Inc.
Five‐year long‐term clinical follow‐up of the XIENCE V everolimus eluting coronary stent system in the treatment of patients with de novo coronary artery lesions: The SPIRIT FIRST trial
Authors: Wiemer Marcus , Serruys Patrick W. , Miquel‐Hebert Karine , Neumann Franz‐Josef , Piek Jan J. , Grube Eberhard , Haase Jürgen , Thuesen Leif , Hamm Christian 
Published: January 2010

AbstractBackground: Drug‐eluting stents have shown to be superior over bare metal stents in clinical and angiographic outcomes after percutaneous treatment of coronary artery stenosis. However, long‐term follow‐up data are scarce and only available for sirolimus‐ and paclitaxel‐eluting stents. Aim: To assess the feasibility and performance of the XIENCE V everolimus‐eluting stent (EES) versus an identical bare metal stent after a 5‐year follow‐up period. Methods: SPIRIT FIRST was a First in Man, multicentre, prospective, single‐blind, clinical trial, randomizing 60 patients with a single de novo coronary artery lesion in a ratio of 1:1 to either an everolimus eluting or a bare metal control stent. Results: At 5‐year clinical follow‐up, data were available in 89% and 86% of patients in the everolimus and control arm, respectively. In the everolimus arm, no additional death, myocardial infarction, clinically driven target lesion revascularization (TLR), or clinically driven target vessel revascularization (TVR) events were observed between 1‐ and 5‐year follow‐up. The 5‐year hierarchical major adverse cardiac events (MACE) and target vessel failure (TVF) rates for the everolimus arm were 16.7% (4/24) for both endpoints. In the control group, no additional cardiac death, myocardial infarction, or clinically driven TLR events were observed between 2‐ and 5‐year follow‐up. No additional clinically driven TVR events were observed between 3‐ and 5‐year follow‐up. The 5‐year hierarchical MACE and TVF rates for the control arm were 28.0% (7/25) and 36.0% (9/25), respectively. No stent thromboses were observed in either the everolimus arm or the control arm up to 5 years. Conclusion: The favorable 5‐year long term clinical outcome of the EES is consistent with the results from other studies of the EES with shorter follow‐up. © 2010 Wiley‐Liss, Inc.
Feasibility of carotid artery stenting in patients with angiographic string sign
Authors: Barker Colin M. , Gomez Jaime , Grotta James C. , Smalling Richard W. 
Published: January 2010

AbstractBackground: Treatment of angiographic string sign (SS) of the carotid artery with carotid endarterectomy or carotid artery stenting (CAS) has been associated with a high incidence of periprocedural neurological events. We describe our experience with CAS in a case series of symptomatic patients with severe carotid stenosis and angiographic SS. Methods: We performed a retrospective review from 1999 to 2009 using our cardiac cath laboratory database and identified nine patients with the angiographic SS who underwent CAS. All patients were referred for carotid angiography by a neurologist due to symptoms (stroke or transient ischemic attack (TIA)). All lesions were predilated and treated with self‐expanding stents. Distal protection devices were utilized (six patients) once they became available. Periprocedural outcomes and long‐term follow‐up was reviewed when available. Results: The average time from onset of symptoms to CAS was 45 days. All CAS procedures were technically and clinically successful without acute complications. One year follow‐up was available in eight patients. One patient had a possible TIA, and the remaining seven patients did not report any events (death, stroke, TIA or myocardial infarction). Carotid ultrasound evaluation at 12 months was available in six patients and showed no evidence of restenosis. Conclusions: In our experience, CAS in patients with severe symptomatic carotid stenosis and angiographic SS is feasible, with an acceptably low periprocedural complication rate. © 2010 Wiley‐Liss, Inc.
Percutaneous closure of multiple defects of the atrial septum: Procedural results and long‐term follow‐up
Authors: Butera Gianfranco , Romagnoli Enrico , Saliba Zakhia , Chessa Massimo , Sangiorgi Giuseppe , Giamberti Alessandro , Cappato Riccardo , Bussadori Claudio , Abella Raul , Pelissero Gabriele , Frigiola Alessandro , Carminati Mario 
Published: January 2010

AbstractBackground: The percutaneous closure of single atrial septal defect (ASD) is a valid alternative to surgery. Objectives: To assess the feasibility of percutaneous treatment of multiple ASDs. Methods: Between 1998 and 2007, 165 out of 1280 consecutive patients undergoing ASD percutaneous closure at our institution showed multiple defects that were classified in four categories: double atrial septal defects (d‐ASD), multifenestrated atrial septal defects (f‐ASD), multifenestrated defects with no signs of right heart overload (f‐PFO), and complex cases (c‐ASD). The following end points were taken into consideration: (1) immediate procedural success; (2) long term safety and efficacy. In this study, up to 81% of multiple ASDs were suitable for percutaneous closure. Results: Multiple device implantations were required in 47% of cases, especially in patients with d‐ASD and c‐ASD. Complication rate, residual shunt, and long term outcome were comparable among the four different categories. In particular, at long term follow‐up (6 ± 2 years) no patient required further surgical or percutaneous treatment and complete closure was confirmed in 99% of cases. Conclusions: Percutaneous closure of multiple ASDs is feasible and associated with a good outcome. A thorough identification and analysis of morphological aspects are mandatory in order to select the appropriate device and the optimal strategy. © 2010 Wiley‐Liss, Inc.
Safety and effectiveness of the INVATEC MO.MA® proximal cerebral protection device during carotid artery stenting: Results from the ARMOUR pivotal trial
Authors: Ansel Gary M. , Hopkins L. Nelson , Jaff Michael R. , Rubino Paolo , Bacharach J. Michael , Scheinert Dierk , Myla Subbarao , Das Tony , Cremonesi Alberto ,   The Investigators for the ARMOUR Pivotal Trial
Published: January 2010

AbstractObjective: The multicenter ARMOUR (ProximAl PRotection with the MO.MA Device DUring CaRotid Stenting) trial evaluated the 30‐day safety and effectiveness of the MO.MA® Proximal Cerebral Protection Device (Invatec, Roncadelle, Italy) utilized to treat high surgical risk patients undergoing carotid artery stenting (CAS). Background: Distal embolic protection devices (EPD) have been traditionally utilized during CAS. The MO.MA device acts as a balloon occlusion “endovascular clamping” system to achieve cerebral protection prior to crossing the carotid stenosis. Methods: This prospective registry enrolled 262 subjects, 37 roll‐in and 225 pivotal subjects evaluated with intention to treat (ITT) from September 2007 to February 2009. Subjects underwent CAS using the MO.MA device. The primary endpoint, myocardial infarction, stroke, or death through 30 days (30‐day major adverse cardiac and cerebrovascular events [MACCE]) was compared to a performance goal of 13% derived from trials utilizing distal EPD. Results: For the ITT population, the mean age was 74.7 years with 66.7% of the cohort being male. Symptomatic patients comprised 15.1% and 28.9% were octogenarians. Device success was 98.2% and procedural success was 93.2%. The 30‐day MACCE rate was 2.7% [95% CI (1.0–5.8%)] with a 30‐day major stroke rate of 0.9%. No symptomatic patient suffered a stroke during this trial. Conclusions: The ARMOUR trial demonstrated that the MO.MA® Proximal Cerebral Protection Device is safe and effective for high surgical risk patients undergoing CAS. The absence of stroke in symptomatic patients is the lowest rate reported in any independently adjudicated prospective multicenter registry trial to date. © 2010 Wiley‐Liss, Inc.
Native chronic total occlusion recanalization after lower limb bypass graft occlusion: A series of nine cases
Authors: Kawarada Osami , Yokoi Yoshiaki 
Published: January 2010

AbstractObjective: The aim of the study was to report the clinical utility of native chronic total occlusion (CTO) recanalization as an endovascular strategy in lower limb bypass graft occlusion. Background: There is no consensus on the best approach for threatened limbs in patients with graft occlusion. Methods: The subjects were nine consecutive patients with limb‐threatening ischemia after bypass graft occlusion. Native CTO recanalization was attempted endovascularly using conventional intraluminal and subintimal angioplasty techniques supported by stents. Results: The mean age of the bypass grafts was 6.7 ± 7.3 (range: 1–24) months and the mean number of previous lower limb bypass surgeries was 1.4 ± 0.5 (range: 1–2). Native CTO recanalization was performed in the iliofemoral (n = 2), iliac (n = 2), superficial femoral (n = 3), popliteal (n = 1), and popliteal‐tibial (n = 1) arteries. Technical success was achieved in 89% (8/9) of cases without complications or major adverse cardiovascular events. The ankle‐brachial index and skin perfusion pressure of the foot significantly increased after revascularization, with marked improvement of clinical symptoms (Rutherford class: 4.5 ± 1.1→0.9 ± 1.4, P < 0.001). Limb salvage was achieved in all successful recanalization cases during the mean follow‐up time of 25 ± 20 months (range: 9–60). Conclusions: In this preliminary study, endovascular recanalization of native CTO showed satisfactory outcomes in patients with bypass graft occlusion. © 2010 Wiley‐Liss, Inc.
Stent thrombosis after complex multivessel stenting in an elderly patient
Authors: Ito Shigenori , Yoshida Takayuki 
Published: January 2010

AbstractWe report a challenging case in terms of procedural difficulty as well as long‐term patency. Multivessel stenting procedures for long subtotal occlusions in the right coronary artery (RCA) and left anterior descending coronary artery (LAD) were successfully performed in an 84‐year‐old female who had complications of severe left ventricular dysfunction and a recent history of gastric ulcer bleeding. Two bare‐metal stents were successfully deployed in the mid and distal RCA. A drug‐eluting stent could only be deployed in the proximal RCA. Two drug‐eluting stents were deployed in the proximal LAD and LMT. Late stent thrombosis in the proximal RCA occurred about 3 months later. We speculated that a lack of aspirin and bare metal stent restenosis were the reasons for the late stent thrombosis. This case was very challenging in terms of balancing the risk of ischemia and bleeding after coronary stent deployment. © 2010 Wiley‐Liss, Inc.
Treatment of splenic artery aneurysm with polytetrafluoroethylene‐covered stent
Authors: Aslam Mohammad Shakil , Shalev Yoseph 
Published: January 2010

AbstractSplenic artery aneurysm (SAA) is a rare condition, mostly treated with surgery. Usually an incidental finding, prevalence varies from 0.04 to 0.10%. If left untreated, SAA carries a high risk of rupture and high mortality. We describe a 53‐year‐old male patient with SAA, where a balloon‐expandable, polytetrafluoroethylene‐covered stent was used for treatment. The stent remains patent without any leakage after 2 years. © 2010 Wiley‐Liss, Inc.
Thrombus aspiration in primary percutaneous coronary intervention in high‐risk patients with ST‐elevation myocardial infarction: A real‐world registry
Authors: Mangiacapra Fabio , Wijns William , De Luca Giuseppe , Muller Olivier , Trana Catalina , Ntalianis Argyrios , Heyndrickx Guy , Vanderheyden Marc , Bartunek Jozef , De Bruyne Bernard , Barbato Emanuele 
Published: January 2010

AbstractObjectives: To evaluate the effect of thrombus aspiration in a real‐world all‐comer patient population with STEMI undergoing primary PCI. Background: Catheter thrombus aspiration in primary PCI was beneficial in randomized clinical trials. Methods: We enrolled 313 STEMI patients presenting with TIMI Flow Grade 0 or 1 in the infarct related artery at baseline angiogram undergoing primary PCI. Patients were divided in two groups based on whether thrombus aspiration was attempted. This decision was left at operator's discretion. Procedural and long‐term clinical outcomes were compared between the two groups. Results: Baseline characteristics were similar between groups: 194 (62%) received thrombus aspiration and 119 underwent conventional PCI. Thrombus aspiration was associated with significantly lower post‐PCI TIMI Frame Count values (19 ± 15 vs. 25 ± 17; P = 0.002) and higher TIMI Flow Grade 3 (92% vs. 73%; P < 0.001). Postprocedural myocardial perfusion assessed by myocardial blush grade (MBG) was significantly increased in the thrombus aspiration group (MBG 3: 44% vs. 21%; P < 0.001). No significant difference was found between the two groups in clinical outcome at 30 days. At one year, patients treated with thrombus aspiration showed significantly higher overall survival (HR 0.41, 95% CI 0.20–0.81; log‐rank P = 0.010) and MACE‐free survival (HR 0.49, 95% CI 0.28–0.85; log‐rank P = 0.011). Conclusions: In real‐world all‐comer STEMI patients with occluded infarct‐related artery, thrombus aspiration prior to PCI improves coronary flow, myocardial perfusion, and long‐term clinical outcome as compared with PCI in the absence of thrombus aspiration. © 2010 Wiley‐Liss, Inc.