bluuebunny/crossref_metadata_2025_split huggingface dataset:
Solution‐Processed Efficient Organic Upconversion Device for Direct NIR Imaging
Authors: Dong Shilong , Zhang Yi , Wang Zehong , Li Jin , Zhou Zichun , Zhu Lei , Zhong Hongliang , Liu Feng , Jiang Xuesong 
Published: May 2024

AbstractInfrared upconversion devices (UCDs) enable NIR imaging without array and readout circuits, making them desirable for portable sensor, imaging and monitoring. However, the exorbitant cost and difficulties in fabrication associated with vacuum‐deposited materials, which are usually employed in high‐performance UCDs, restrict their application in flexible‐stretchable systems. Here, a solution‐processed upconversion device (s‐UCD), which is composed of detector and emitter, with high conversion efficiency and low turn‐on voltage achieved by device structure design and interlayer engineering is reported. The role of the electron blocking layer is investigated in s‐UCDs, and a peak luminance of 5,500 cd m−2 @7 V and a luminance on‐off ratio of 110000 @5.25 V are achieved. The s‐UCDs exhibit high resolution, microsecond response time and are compatible with flexible substrates. With the high‐performance large‐area s‐UCDs, direct non‐invasive transmission‐based bioimaging applications with high quality of bioimaging are further performed. It is believed that the s‐UCD imaging system offers potential applications for portable low‐cost non‐invasive tissue analysis, disease diagnosis, and virtual reality.
Synthesis of Fluorinated Spiroindolenines by Transition Metal‐Catalyzed Indole Dearomatizations
Authors: Buttard Floris , Daghmoum Meriem , Arribat Mathieu , Chen Mu‐Yi , Retailleau Pascal , Besset Tatiana , Guinchard Xavier 
Published: May 2024

AbstractA strategy to access fluorinated spiroindolenines has been developed, involving a selective functionalization of indoles with fluorinated moieties and subsequent catalytic dearomatization. Trifluomethylthio (SCF3), diethyl phosphono(difluoromethyl)thio (SCF2P(O)(OEt)2) and (phenylsulfonyl)difluoromethyl (CF2SO2Ph) groups were embedded at the C2 position of indole derivatives substituted with alkynes, allenes, and allyl carbonate moieties at the C3 position. A gold‐catalyzed cycloisomerization gave access to five spiroindolenines, and an enantioselective palladium catalyzed cyclization provided 10 fluorinated spirocyclic products with up to 77% ee.
The Role of Tumor‐Derived Extracellular Vesicles in Drug Resistance in Urologic Cancers
Authors: Xiong Zhuang , Chen Tingting , Wu Shuang , Deng Min , Wu Qingjian , Huang Dandan , He Changying , Li Chong , Zheng Ji 
Published: May 2024

AbstractIn spite of the therapeutic progress achieved in the treatment of urologic tumors, the persistence and intricate nature of tumor resistance significantly impact patient prognoses. Extracellular vesicles (EVs), actively secreted by diverse cell types, assume a crucial role in facilitating intercellular communication. These EVs facilitate the transfer of functional molecules, encompassing RNA, proteins, and lipids, to recipient cells. While these molecules participate in normal physiological processes, they also play a pivotal role in the pathogenesis of various diseases. Notably in the context of cancer, numerous investigations have substantiated the involvement of tumor‐derived EVs in the development of drug resistance. This review comprehensively explores the mechanisms underlying drug resistance in urologic cancers, elucidates the contributions of tumor‐derived EVs to drug resistance in urologic tumors, discusses advancements in targeting EVs to mitigate drug resistance in urologic tumors, and assesses the utility of EVs as biomarkers for drug resistance in urologic tumors.
Cytochalasin B‐Induced Membrane Vesicles of NK Cells for Efficient Tumor Immunotherapy
Authors: Lee Minseon , Kwon Soonjo 
Published: May 2024

AbstractExtracellular vesicles (EVs) are crucial mediators of cell‐to‐cell communication and contain biological components such as lipids, proteins, and nucleic acids. EVs are studied for their crucial immunomodulatory roles, particularly in natural killer (NK) cells. NK vesicles, which share surface markers and biological components with the parental NK cells, are developed as anti‐cancer agents. However, their clinical application is hindered by their low productivity and an incomplete understanding of their functional mechanisms. In this study, EV‐mimicking vesicles are artificially induced from NK cells by cytochalasin B treatment. These cytochalasin B‐induced membrane vesicles (CIMVs) are 1.21‐fold more concentrated than isolated natural EVs from NK cells (NK‐EVs) and contain 1.66‐fold more proteins, including those with immunological activity against tumors. The induced ARF6‐positive microvesicles possess an immunological phenotype similar to that of the parental cells, while perforin, granzyme, and FasL proteins are more abundant compared to NK‐EVs. Administrating NK‐EVs and CIMVs to K562 and MCF‐7 tumor cells induces caspase‐dependent apoptosis, which leads to tumor cell cytotoxicity. These results significantly contribute to the understanding of the role of NK vesicles in cellular communication and immunity, and highlight the therapeutic potential of engineered NK‐EVs via their specific action on tumor cells.
Synthetic Biomimetic Liposomes Harness Efferocytosis Machinery for Highly Efficient Macrophages‐Targeted Drug Delivery to Alleviate Inflammation
Authors: Han Run , Ren Zhengyu , Wang Qi , Zha Haidong , Wang Erjin , Wu Mingyue , Zheng Ying , Lu Jia‐Hong 
Published: May 2024

AbstractMacrophages play pivotal roles in the regulation of inflammatory responses and tissue repair, making them a prime target for inflammation alleviation. However, the accurate and efficient macrophages targeting is still a challenging task. Motivated by the efficient and specific removal of apoptotic cells by macrophages efferocytosis, a novel biomimetic liposomal system called Effero‐RLP (Efferocytosis‐mediated Red blood cell hybrid Liposomes) is developed which incorporates the membrane of apoptotic red blood cells (RBCs) with liposomes for the purpose of highly efficient macrophages targeting. Rosiglitazone (ROSI), a PPARγ agonist known to attenuate macrophage inflammatory responses, is encapsulated into Effero‐RLP as model drug to regulate macrophage functions in DSS‐induced colitis mouse model. Intriguingly, the Effero‐RLP exhibits selective and efficient uptake by macrophages, which is significantly inhibited by the efferocytosis blocker Annexin V. In animal models, the Effero‐RLP demonstrates rapid recognition by macrophages, leading to enhanced accumulation at inflammatory sites. Furthermore, ROSI‐loaded Effero‐RLP effectively alleviates inflammation and protects colon tissue from injury in the colitis mouse model, which is abolished by deletion of macrophages from mice model. In conclusion, the study highlights the potential of macrophage targeting using efferocytosis biomimetic liposomes. The development of Effero‐RLP presents novel and promising strategies for alleviating inflammation.
2D and 3D Self‐Assembly of Fluorine‐Free Pillar‐[5]‐Arenes and Perfluorinated Diacids at All‐Aqueous Interfaces
Authors: Honaker Lawrence W. , Gao Tu‐Nan , de Graaf Kelsey R. , Bogaardt Tessa V.M. , Vink Pim , Stürzer Tobias , Kociok‐Köhn Gabriele , Zuilhof Han , Miloserdov Fedor M. , Deshpande Siddharth 
Published: May 2024

AbstractThe interaction of perfluorinated molecules, also known as “forever chemicals” due to their pervasiveness, with their environment remains an important yet poorly understood topic. In this work, the self‐assembly of perfluorinated molecules with multivalent hosts, pillar‐[5]‐arenes, is investigated. It is found that perfluoroalkyl diacids and pillar‐[5]‐arenes rapidly and strongly complex with each other at aqueous interfaces, forming solid interfacially templated films. Their complexation is shown to be driven primarily by fluorophilic aggregation and assisted by electrostatic interactions, as supported by the crystal structure of the complexes, and leads to the formation of quasi‐2D phase‐separated films. This self‐assembly process can be further manipulated using aqueous two‐phase system microdroplets, enabling the controlled formation of 3D micro‐scaffolds.
Recent Progress of Electrolyte Materials for Solid‐State Lithium–Oxygen (Air) Batteries
Authors: Lu Tengda , Qian Yundong , Liu Ke , Wu Can , Li Xue , Xiao Jie , Zeng Xiaoyuan , Zhang Yingjie , Chou Shu‐Lei 
Published: May 2024

AbstractSolid‐state lithium–air batteries (SSLABs) have become the focus of next‐generation advanced batteries due to their safety and high energy densities. Current research on SSLABs is mainly centered on solid‐state electrolytes (SSEs). Although SSEs exhibit excellent properties, such as good stability, high safety, and great mechanical strength, they also display several distinct weaknesses of low ionic conductivities, poor stabilities in air, and high interfacial impedances, which will require sustained attentions for further investigations. This review first overviews the development history of SSEs achieved in terms of Li–air batteries. Subsequently, the fundamental properties, preparation methods, merits and drawbacks of different SSEs, along with their use in SSLABs, and the optimization strategy, especially for the inorganic solid electrolytes, polymer electrolytes, and hybrid electrolytes are comprehensively summarized. Finally, the research progresses made with SSEs are outlined, and critical insights and approaches for the remaining challenges of electrolytes and commercial application of SSLABs are proposed, which include advanced characterization, combining experiments and artificial intelligence such as theoretical calculations, and constructing selective permeability membranes. It is expected that this timely review will provide researchers with an integrated, systematic, and in‐depth understanding of SSEs and guidelines for future research, thus further promoting the commercial application of SSLABs.
Inhibiting Dendrites by Uniformizing Microstructure of Superionic Lithium Argyrodites for All‐Solid‐State Lithium Metal Batteries
Authors: Liu Yu , Su Han , Zhong Yu , Zheng Matthew , Hu Yang , Zhao Feipeng , Kim Jung Tae , Gao Yingjie , Luo Jing , Lin Xiaoting , Tu Jiangping , Sun Xueliang 
Published: May 2024

AbstractThe all‐solid‐state lithium metal battery is considered the next‐generation energy storage device with the potential to double the energy density of state‐of‐the‐art Li‐ion batteries and eliminate safety hazards. Achieving stable Li plating/stripping without dendrite propagation within the solid electrolyte is crucial for delivering the promised high energy density. In this study, through the comparison of various synthesis routes, a novel cube‐shaped microstructure in the Li5.3PS4.3ClBr0.7 argyrodite electrolyte, synthesized using the high‐speed mechanical milling followed by annealing method (BMAN‐LPSCB) is identified. The uniform microstructure allows for the production of an electrolyte pellet with significantly reduced porosity through cold pressing. The removal of defects has significantly enhanced the electrolyte's ability to inhibit dendrite formation, with a critical current density reaching 3.8 mA cm−2. The lithium symmetric cell with BMAN‐LPSCB electrolyte exhibits stable Li plating/stripping for over 150 h at a high current density and cutoff capacity of 3 mA cm−2 / 3 mAh cm−2. The all‐solid‐state Li/NCM battery utilizing the BMAN‐LPSCB electrolyte also demonstrates excellent durability, with a capacity retention of 96% over 1000 cycles at a 1C rate. This study emphasizes that the microstructure of the sulfide electrolyte is a critical factor influencing mechanically‐driven Li dendrite propagation in all‐solid‐state batteries.
Direct Regeneration of Spent LiCoO2 Black Mass Based on Fluorenone‐Mediated Lithium Supplementation and Energy‐Saving Structural Restoration
Authors: Xu Mingli , Wu Chen , Ye Lang , Zhang Yuanteng , Zhang Chenyi , Hu Jieming , Tan Ran , Gu Dong , Wang Xuanze , Fontaine Olivier , Zhan Chun , Zhuang Lin , Ai Xinping , Qian Jiangfeng 
Published: May 2024

AbstractDegraded LiCoO2 cathode from retired Li‐ion batteries is urgently required to be recycled in a greener way for economic and environmental considerations. The coarse metallurgy technologies for Li/Co extraction with massive CO2 emission and energy consumption cannot satisfy the requirements of carbon neutralization. Herein, it is proposed that direct regeneration of degraded LiCoO2 cathode could be realized via 9‐fluorenone‐mediated Li supplementation and follow‐up structural restoration. The 9‐fluorenone‐lithium reagent is elaborately selected to compensate for the missing Li+ into lattice with targeted stoichiometry owing to its compatible redox potential of 1.95 V versus Li+/Li, which is located just between the reversible intercalation (3.8 V) and irreversible conversion (1.2 V) potentials of LiCoO2 electrode. Then, thermal energy‐driven structure reorganization enables Li/Co atoms to occupy the right sites, accomplishing desirable structure healing within a short annealing time of 4 h. The regenerated LiCoO2 cathode exhibits comparable Li‐storage capability to commercial LiCoO2, benefiting from the non‐destructive direct regeneration technology. In addition, the regeneration route is regarded as environmentally (0.13 kg CO2 kg−1 cell) and economically (10.07 $ kg−1 cell) superior to conventional recycling routes based on life‐cycle analysis. The precise surgery on spent LiCoO2 cathode provides a promising solution for the forthcoming retirement rush of Li‐ion batteries.
Expansion of the prenatal phenotype of Baraitser–Winter syndrome: Presentation of two cases of multiple congenital anomaly syndrome
Authors: Burrill Natalie , Crane Haley , Khalek Nahla , Soni Shelly , Wild K. Taylor , Skraban Cara , McManus Morgan , Szigety Katherine , Oliver Edward R. , Partridge Emily , Agarwal Sonika , Fisher Allan , Wang Jing , Moldenhauer Julie S. 
Published: May 2024

AbstractBaraitser–Winter cerebrofrontofacial syndrome (BWCFF) is a variable multiple congenital anomaly condition, typically presenting postnatally with neurocognitive delays, distinctive facial features, cortical brain malformations, and in some, a variety of additional congenital malformations. However, only a few cases have reported the prenatal presentation of this syndrome. Here, we report two cases of BWCFF and their associated prenatal findings. One case presented with non‐immune hydrops fetalis and a horseshoe kidney and was found to have a de novo heterozygous variant in ACTB (c.158A>G). The second case presented with gastroschisis, bilateral cleft lip and palate, and oligohydramnios, and was found to harbor a different de novo variant in ACTB (c.826G>A). Limited reports exist describing prenatally identified anomalies that include fetal growth restriction, increased nuchal fold, bilateral hydronephrosis, rocker bottom foot, talipes, cystic hygroma, omphalocele, and hydrops fetalis. In addition, only three of these cases have included detailed prenatal imaging findings. The two prenatal cases presented here demonstrate an expansion of the prenatal phenotype of BWCFF to include gastroschisis, lymphatic involvement, and oligohydramnios, which should each warrant consideration of this diagnosis in the setting of additional anomalies.
Spin Transport in High‐Field Superconductors
Authors: Beckmann Detlef 
Published: May 2024

AbstractHigh‐field superconductors are characterized by a spin splitting of the density of states, giving rise to spin transport phenomena. This includes spin‐polarized tunneling, spin‐dependent thermoelectric effects, long‐range quasiparticle spin transport, and spin‐dependent coupling of supercurrents and quasiparticles. This review gives a brief overview of the theory background, recent experimental progress in the field, and an outlook on open problems and possible applications.
Building Functional Liquid‐Based Interfaces: From Mechanism to Application
Authors: Fan Yi , Huang Xinlu , Ji Jiaao , Zhang Wenli , Zhang Jian , Hou Xu 
Published: May 2024

AbstractFunctional liquid‐based interfaces, with their inhomogeneous regions that emphasize the functionalized liquids, have attracted much interest as a versatile platform for a broad spectrum of applications, from chemical manufacturing to practical uses. These interfaces leverage the physicochemical characteristics of liquids, alongside dynamic behaviors induced by macroscopic wettability and microscopic molecular exchange balance, to allow for tailored properties within their functional structures. In this Minireview, we provide a foundational overview of these functional interfaces, based on the structural investigations and molecular mechanisms of interaction forces that directly modulate functionalities. Then, we discuss design strategies that have been employed in recent applications, and the crucial aspects that require focus. Finally, we highlight the current challenges in functional liquid‐based interfaces and provide a perspective on future research directions.
Rational Design of the Spatial Effect in a Fe(II)/α‐Ketoglutarate‐Dependent Dioxygenase Reverses the Regioselectivity of C(sp3)−H Bond Hydroxylation in Aliphatic Amino Acids
Authors: Zheng Chenni , Wei Wanqing , Wen Jian , Song Wei , Wu Jing , Wang Ran , Yin Dejing , Chen Xiulai , Gao Cong , Liu Jia , Liu Liming 
Published: May 2024

AbstractThe hydroxylation of remote C(sp3)−H bonds in aliphatic amino acids yields crucial precursors for the synthesis of high‐value compounds. However, accurate regulation of the regioselectivity of remote C(sp3)−H bonds hydroxylation in aliphatic amino acids continues to be a common challenge in chemosynthesis and biosynthesis. In this study, the Fe(II)/α‐ketoglutarate‐dependent dioxygenase from Bacillus subtilis (BlAH) was mined and found to catalyze hydroxylation at the γ and δ sites of aliphatic amino acids. Crystal structure analysis, molecular dynamics simulations, and quantum chemical calculations revealed that regioselectivity was regulated by the spatial effect of BlAH. Based on these results, the spatial effect of BlAH was reconstructed to stabilize the transition state at the δ site of aliphatic amino acids, thereby successfully reversing the γ site regioselectivity to the δ site. For example, the regioselectivity of L‐Homoleucine (5 a) was reversed from the γ site (1 : 12) to the δ site (>99 : 1). The present study not only expands the toolbox of biocatalysts for the regioselective functionalization of remote C(sp3)−H bonds, but also provides a theoretical guidance for the precision‐driven modification of similarly remote C(sp3)−H bonds in complex molecules.
An oxo‐acetato‐bridged trinuclear cobalt(III) cluster‐persuaded cobalt oxide active electrocatalyst for efficient hydrogen evolution activity
Authors: Sarkar Gayetri , Diyali Nilankar , Mondal Bipul , Agrawalla Suraj Kumar , Purohit Chandra Shekhar , Das Hari Sankar , Biswas Bhaskar 
Published: May 2024

This study presents the synthesis and electrocatalytic performance of the cobalt(III) complex [Co3(μ1,1,1‐O)(μ1,3‐CH3CO2)(L)3]2(DMF)3 (Cotri), featuring a double deprotonated (N,O)‐donor ligand (L2‐), where the protonated form of it (H2L) is 2,2′‐(hydrazine‐1,2‐diylidenebis(ethan‐1‐yl‐1‐ylidene))diphenol. The X‐ray structure reveals a trinuclear cobalt cluster formed with three cobalt(III) centers interlinking through oxido (μ1,1,1‐O) and acetato (μ1,3‐O2CCH3) bridges in coupling with bis‐congregator‐type chelating ligands. Cotri adopts cobalt centers of octahedral and trigonal bipyramidal coordination geometries and bears a dominant Co(2)…H(DMF) agostic interactions appraised by lattice dimethyl formamide (DMF) molecules. Further, Cotri shows promising heterogeneous electrocatalytic hydrogen evolution activity in 1 M KOH, with an overpotential of 441 mV to achieve 10 mA/cm2 current density. Tafel slope analysis suggests the Volmer–Heyrovsky step as the rate‐determining step. The number of active sites and TOF for Cotri were estimated at 4.010 × 10−8 mol and 0.2467 s−1, respectively, ensuring its excellent hydrogen generation activity. Stability assessments through controlled potential electrolysis (CPE) and cyclic voltammetry (CV) for multiple cycles addressed the transformation of Cotri to Co2O3 nanoparticles, which turned out to be a more active Co2O3 electrocatalyst. The morphology and particle size of the in situ developed Co2O3 active catalyst under the electrochemical conditions attributes to the superior hydrogen evolution activity.
Beyond static: Tracking the dynamic nature of water absorption and Young's modulus in IPMC devices
Authors: Saccardo Matheus Colovati , Barbosa Rafael , Zuquello Ariel G. , Blanco Guilherme Eduardo de Oliveira , Tozzi Kaique A. , Gonçalves Roger , Scuracchio Carlos H. 
Published: May 2024

AbstractIonomeric polymer‐metal composites (IPMC) are advanced materials designed to mimic biological systems. Their performance depends on various factors, including electrical stimulus intensity, membrane hydration, ionic migration, and Young's modulus. However, there is a lack of studies in the literature investigating how the water absorption capacity and elastic modulus change over time in IPMCs. Understanding the hydration level variation as a function of time is essential because as this parameter deviates, the ionic migration capacity and Young's modulus also change, altering the device's electromechanical efficiency over time. To address this research gap, Nafion/Pt‐based IPMC devices exchanged with four monovalent cations (H+, Li+, Na+, and K+) and one ionic liquid (1‐butyl‐3‐methylimidazolium—BMIM+) were prepared, and a comprehensive investigation on how the water absorption capacity and Young's modulus vary as a function of time, relative humidity (RH), and counterion size was performed. The results revealed that the water uptake capacity is significantly higher and occurs more rapidly at higher RH levels and when the counterion's ionic radius decreases. Consequently, the time required for the device to reach osmotic equilibrium can range from 40 to 270 min, depending on the RH and counterion used. Furthermore, it was observed that the first natural frequency and Young's modulus also exhibit time‐dependent behavior. Under constant RH conditions, the mechanical properties of the IPMC can vary by up to 50% in less than 60 min. Notably, the combined results from water uptake capacity, Young's modulus, electrochemical impedance spectroscopy, and electromechanical response analyses (including blocking force, displacement, displacement rate, current, coulombic efficiency, and voltage) suggest that a morphological transformation within the polymer is likely to occur once RH exceeds 60%. This finding strengthens the hypothesis that ion migration is mainly influenced by their movement through Nafion's ionomeric channels rather than the filling of ionic agglomerates.