bluuebunny/crossref_metadata_2025_split huggingface dataset:
International creative tension study of university students in South Korea and Finland
Authors: Chang Yoon , Eklund Tomas , Kantola Jussi I. , Vanharanta Hannu 
Published: September 2009

AbstractThe goal of this research was to compare the creative tension of university students in South Korea and Finland at three different universities. The creative tension, or the gap between a personal vision and the current reality, was analyzed according to relevant competences in a project manager's work role. In this case, students acted as the project managers in their role of completing all the requirements of their degree. The application used for collecting and analyzing the data was Cycloid, a project manager's work role–based competence application and a model in the generic Evolute system supporting fuzzy logic applications. Data for 108 university students were collected online through self‐evaluations. The application was able to identify the creative tension in each group of university students, and the results show major differences in creative tension across the universities (and also between countries). This type of in‐depth analysis into the cultural perceptions of attributes offers valuable new information for academia and businesses in the assessment and improvement of multicultural understanding and cooperation in areas of mutual interest and business. © 2009 Wiley Periodicals, Inc.
Ursodeoxycholic acid switches oxaliplatin‐induced necrosis to apoptosis by inhibiting reactive oxygen species production and activating p53‐caspase 8 pathway in HepG2 hepatocellular carcinoma
Authors: Lim Sung‐Chul , Choi Jeong Eun , Kang Ho Sung , SI Han 
Published: September 2009

AbstractHepatocellular carcinoma (HCC) is resistant to chemotherapy. Recently, however, several oxaliplatin‐based combinatorial treatments have shown a promising anti‐tumor activity in patients with HCC. Presently, we demonstrate that oxaliplatin triggers necrosis more than apoptosis in HepG2, SK‐Hep1, SNU‐423 and Hep3B HCC cells, while mainly inducing apoptosis in HCT116 and HT29 colon cancer cells. Interestingly, ursodeoxycholic acid (UDCA), a less hydrophobic bile acid that can suppress carcinogenesis, shifted oxaliplatin‐induced necrosis to apoptosis in HepG2 cells. The same effect was produced by hydrophilic bile acids (tauroursodeoxycholic acid and taurohyodeoxycholic acid), but not by highly hydrophobic bile acids (deoxycholic acid and chenodeoxycholic acid). UDCA also triggered the necrosis‐to‐apoptosis switch when cotreated with other platinum‐based chemotherapeutic drugs including cisplatin and carboplatin, suggesting that the cell death mode switching effect of UDCA is a general phenomenon when combined with platinum drugs. Oxaliplatin produced high level of reactive oxygen species (ROS) in HepG2 cells and UDCA significantly reduced oxaliplatin‐induced ROS generation. In addition, N‐acetyl‐L‐cysteine and the superoxide scavengers butylated hydroxyanisole and dihydroxybenzene‐3,5‐disulfonic acid attenuated necrosis, indicating a critical role(s) of ROS in occurrence of necrotic death. Apoptosis induced by combined treatment appeared to be mediated by p53‐caspase 8‐caspase 3 pathway. In conclusion, UDCA switches oxaliplatin‐induced necrosis to apoptosis via inhibition of ROS production and activation of the p53‐caspase 8 pathway in HepG2 cells. As necrosis and subsequent inflammation are implicated in tumor progression and malignancy, our results imply a potential improved efficacy of UDCA‐combined chemotherapy in HCC by reducing inflammatory responses that may be triggered by oxaliplatin.
Lung cancer mortality trends in 36 European countries: secular trends and birth cohort patterns by sex and region 1970–2007
Authors: Bray Freddie Ian , Weiderpass Elisabete 
Published: September 2009

AbstractSmoking is a major contributor to all‐cause mortality in Europe and accounts for one‐fifth of the cancer‐related deaths. Monitoring the tobacco epidemic via an analysis of lung cancer trends is essential in helping countries arrest the effects of tobacco epidemic in the region. The study aims to provide a comprehensive and up‐to‐date overview of the temporal patterns of lung cancer mortality in Europe, emphasizing country‐ and sex‐specific differences. National lung cancer mortality data were extracted from the WHO mortality databank by age, sex, year of death (1970–2007) for 36 countries in Europe. Trends in lung cancer mortality in men have tended to decrease in many European countries during the last two decades, particularly in North and Western Europe. Among women, mortality rates are still increasing in many countries, although in a few populations, rates are beginning to stabilize, notably in the high‐risk countries within Eastern Europe (Hungary, Poland and the Czech Republic), and in Northern Europe (Denmark, Iceland and the United Kingdom). Men and women are clearly in very different phases of the smoking epidemic, and, as reflected in the mortality rates by birth cohort, the stage varies widely by country within each European region. That lung cancer mortality trends in men are on a downwards path in most European countries while female rates continue to rise, points to an urgent need for national and European prevention strategies that target tobacco cessation and prevention among European women.
Business cycle synchronization of the euro area with the new and negotiating member countries
Authors: Savva Christos S. , Neanidis Kyriakos C. , Osborn Denise R. 
Published: September 2009

AbstractWe examine business cycle synchronizations between the euro area and the recently acceded EU and currently negotiating countries. Strong evidence is uncovered of time‐variation in the degree of co‐movement between the cyclical components of monthly industrial production indicators for each of these countries with a euro area aggregate, which is modelled through a bivariate VAR‐GARCH specification with a smoothly time‐varying correlation that allows for structural change. Where required to account for the observed time‐variation in correlations, a double smooth transition conditional correlation model is used to capture a second structural change event. After allowing for dynamics, we find that all new EU members and negotiating countries have at least doubled their business cycle synchronization with the euro area or changed from negative to positive correlations, since the early 1990s. Furthermore, some have exhibited U‐curved or hump‐shaped business cycle correlation patterns. The results point to great variety in timing and speed of the correlation shifts across the country sample. Copyright © 2009 John Wiley & Sons, Ltd.
Child temperament in three U.S. cultural groups
Authors: Bornstein Marc H. , Cote Linda R. 
Published: September 2009

AbstractTemperament among children (N = 111 20‐month‐olds) from three cultural backgrounds in the United States (Latin American, Japanese American, and European American) was investigated. In accord with a biobehavioral universalist perspective on the expression of early temperament, few significant group differences in child temperament were found, regardless of cultural background; however, factors associated with maternal reports of child temperament differed by cultural group. The findings provide insight into the nature of child temperament generally and temperament of children in immigrant families specifically as well as parenting in immigrant families.
Predictors of coparenting in Mexican American families and links to parenting and child social emotional development
Authors: Cabrera Natasha J. , Shannon Jacqueline D. , La Taillade Jaslean J. 
Published: September 2009

AbstractThe present study examined associations between parents' levels of acculturation depressive symptoms, family support, and couple relationship quality with coparenting conflict. We also explored the effects of coparenting conflict on parenting and infant social development in a sample of low‐income Mexican American (n = 735) infants (age 9 months) and their parents. Results indicated that couple conflict was the strongest predictor of coparenting conflict. Coparenting conflict had a significant effect on mother‐‐infant interaction and father engagement. The effects of coparenting on father caregiving varied by father's level of acculturation; when there is high coparenting conflict, more acculturated fathers engaged in more caregiving than do less acculturated fathers. Coparenting conflict was not predictive of infant social development.
Leptin and insulin induce mutual resistance for nitric oxide synthase III activation in adipocytes
Authors: Mehebik‐Mojaat Nadia , Ribière Catherine , Niang Fatoumata , Forest Claude , Jaubert Anne‐Marie 
Published: September 2009

AbstractObesity‐induced hyperleptinemia is frequently associated with insulin resistance suggesting a crosstalk between leptin and insulin signaling pathways. Our aim was to determine whether insulin and leptin together interfere on NOS activation in adipocytes. We examined insulin and leptin‐induced nitric oxide synthase (NOS) activity, protein amount and NOS III phosphorylation at Ser1179 in isolated epididymal adipocytes from rat, in the presence or not of inhibitors of kinases implicated in insulin or leptin signaling pathways. Insulin or leptin induced NOS III phosphorylation at Ser1179 leading to increased NO production in rat adipocytes, in agreement with our previous observations. When insulin and leptin at a concentration found in obese rats (10 ng/ml) were combined, NOS activity was not increased, suggesting a negative crosstalk between insulin and leptin signaling mechanisms. Chemical inhibitors of kinases implicated in signaling pathways of insulin, such as PI‐3 kinase, or of leptin, such as JAK‐2, did not prevent this negative interaction. When leptin signaling was blocked by PKA inhibitors, insulin‐induced NOS activity and NOS III phosphorylation at Ser1179 was observed. In the presence of leptin and insulin, (i) IRS‐1 was phosphorylated on Ser307 and this effect was prevented by PKA inhibitors, (ii) JAK‐2 was dephosphorylated, an effect prevented by SHP‐1 inhibitor. A mutual resistance occurs with leptin and insulin. Leptin phosphorylates IRS‐1 to induce insulin resistance while insulin dephosphorylates JAK‐2 to favor leptin resistance. This interference between insulin and leptin signaling could play a crucial role in insulin‐ and leptin‐resistance correlated with obesity. J. Cell. Biochem. 108: 982–988, 2009. © 2009 Wiley‐Liss, Inc.
A novel approach for correlative light electron microscopy analysis
Authors: Vicidomini Giuseppe , Gagliani Maria C. , Cortese Katia , Krieger Jens , Buescher Peter , Bianchini Paolo , Boccacci Patrizia , Tacchetti Carlo , Diaspro Alberto 
Published: September 2009

AbstractCorrelative light and electron microscopy (CLEM) is a multimodal technique of increasing utilization in functional, biochemical, and molecular biology. CLEM attempts to combine multidimensional information from the complementary fluorescence light microscopy (FLM) and electron microscopy (EM) techniques to bridge the various resolution gaps. Within this approach the very same cell/structure/event observed at level can be analyzed as well by FLM and EM. Unfortunately, these studies turned out to be extremely time consuming and are not suitable for statistical relevant data. Here, we describe a new CLEM method based on a robust specimen preparation protocol, optimized for cryosections (Tokuyasu method) and on an innovative image processing toolbox for a novel type of multimodal analysis. Main advantages obtained using the proposed CLEM method are: (1) hundred times more cells/structures/events that can be correlated in each single microscopy session; (2) three‐dimensional correlation between FLM and EM, obtained by means of ribbons of serial cryosections and electron tomography microscopy (ETM); (3) high rate of success for each CLEM experiment, obtained implementing protection of samples from physical damage and from loss of fluorescence; (4) compatibility with the classical immunogold and immunofluorescence labeling techniques. This method has been successfully validated for the correlative analysis of Russel Bodies subcellular compartments. Microsc. Res. Tech., 2010. © 2009 Wiley‐Liss, Inc.
Synthesis and antifungal evaluation of hydroxy‐3‐phenyl‐2H‐1,3‐benzoxazine‐2,4(3H)‐diones and their thioanalogs
Authors: Skála Pavel , Macháček Miloš , Vejsová Marcela , Kubicová Lenka , Kuneš Jiří , Waisser Karel 
Published: September 2009

Abstract
magnified imageA series of substituted 5‐, 6‐, 7‐, and 8‐hydroxy‐3‐phenyl‐2H‐1,3‐benzoxazine‐2,4(3H)‐diones (5–8) was synthesized by cyclization of corresponding dihydroxy‐N‐phenylbenzamides (1–4) with methyl chloroformate. The starting compounds 1–4 were prepared by the reaction of the respective dihydroxybenzoic acid, aniline and phosphorus trichloride via microwave irradiation. Thionation of compounds 8a, 8b, 8c, 8d employing Lawesson's reagent was used to prepare 5‐hydroxy‐3‐phenyl‐4‐thioxo‐3,4‐dihydro‐2H‐1,3‐benzoxazin‐2‐ones (10a, 10b, 10c, 10d) and 5‐hydroxy‐3‐phenyl‐2H‐1,3‐benzoxazine‐2,4(3H)‐dithiones (11a, 11b, 11c, 11d). The position of sulfur in monothionated derivatives 9c and 10a, 10b, 10c, 10d was confirmed by 2D NMR methods. Attempts to prepare dithionated derivatives from the isomeric 6‐, 7‐ or 8‐hydroxy compounds 5–7 failed. All compounds were tested for their in vitro antifungal activity against eight test strains. Compounds 1–4 showed moderate activity and the cyclization to corresponding hydroxy‐3‐phenyl‐2H‐1,3‐benzoxazine‐2,4(3H)‐diones (5–8) resulted in a decrease in antifungal activity. No antifungal activity was observed in thionated compounds 9c and 10–11. J. Heterocyclic Chem., (2009).
Synthesis of [2,4‐bis(arylamino)thiazol‐5‐yl](1‐methyl‐1H‐benzimidazol‐2‐yl)methanones
Authors: Abbs Fen Reji T. F. , Rajasekharan Kallikat N. 
Published: September 2009

Abstract
magnified image[2,4‐Bis(arylamino)thiazol‐5‐yl]‐(1‐methyl‐1H‐benzimidazol‐2‐yl)methanones, as the analogs of the cytotoxic marine alkaloid dendrodoine, are synthesized and characterized by elemental analysis, IR, NMR, and Mass spectral data. The thiourea derivatives provide four ring atoms for the thiazole ring construction and thus act as [CNCS] synthons. The remaining carbon of the thiazole is sourced from 2‐(2‐bromoacetyl)‐1‐methyl‐1H‐benzimidazole. This [4+1] heterocyclization reaction is adopted for the synthesis of novel 1‐methyl‐1H‐benzimidazole derivatives. J. Heterocyclic Chem., (2009).
An efficient and convenient multicomponent reaction for the synthesis of 2‐methyl‐4,6‐diarylpyrimidine under solvent‐free conditions
Authors: Rong Liangce , Han Hongxia , Jiang Hong , Dai Yisi , Zhuang Mengjie , Cao Minxiang , Tu Shujiang 
Published: September 2009

Abstract
magnified imageAn efficient and convenient method for the preparation of 2‐methyl‐4,6‐diarylpyrimidine derivatives by the multicomponent reactions of aromatic aldehydes, aromatic ketones, and acetamidine hydrochloride in the presence of sodium hydroxide under solvent‐free conditions was reported. This method has the advantages of excellent yields, mild reaction conditions, easy workup, and environmentally friendly procedure. J. Heterocyclic Chem., (2009).
Near‐infrared bis(indolium heptamethine cyanine) dyes with a spacer derived from oligo(ethylene glycol)
Authors: Wolinska Ewa , Henary Maged , Paliakov Ekaterina , Strekowski Lucjan 
Published: September 2009

Abstract
magnified imageSynthesis of a series of near‐infrared dimeric dyes is presented. The intramolecular dimers contain two chromophores linked with a conformationally flexible ether or oligoether bridge. Optical properties of the dyes are discussed. J. Heterocyclic Chem., (2009).
Synthesis of halogenoindirubins
Authors: Tanoue Yasuhiro , Ikoma Yousuke , Kai Norihisa , Nagai Takeshi 
Published: September 2009

Abstract
magnified imageThe synthesis of halogenoindirubins was attempted. The reaction of 3‐acetoxy‐6‐bromoindole (5) with 6‐bromoisation (10) in methanol with Na2CO3 produced 6‐bromo‐6′‐fluoroindirubin (11) in 80% yield. Its structure determination was mainly undertaken using 1H NMR spectroscopy. A similar reaction gave 6′‐bromoindirubin (12) and 6‐bromoindirubin (3) in moderate yields. J. Heterocyclic Chem., (2009).
A simple, efficient, one‐pot three‐component domino synthesis of Hantzsch pyridines under solvent‐free condition
Authors: Nasr‐Esfahani Masoud , Karami Bahador , Behzadi Masoume 
Published: September 2009

Abstract
magnified imageIn this article, efficient and simple preparation of Hantzsch pyridine derivatives by reaction of various aldehydes and β‐dicarbonyls in the presence of ammonium chlorate under solvent‐free condition at 80°C is reported. The advantages of this system are the one‐step procedure, high yields of the products, and the ability to carry out large‐scale reactions. J. Heterocyclic Chem., (2009).
Managed care physician organizations: Next generation of healthcare reform
Authors: Harri Stephen F. 
Published: September 2009

AbstractThis article focuses on the evolution of physician‐sponsored organizations in the managed care continuum. Given the amount of influence that physicians have on the overall level of healthcare expenditures within the U.S. economy, physician commitment to the managed care process is critical to truly drive the next round of managed care initiatives. The capital markets have recognized this and have contributed significant amounts of capital to fuel the development of for‐profit models called physician practice management companies.
The role of placental examination and its pathology in obstetric risk management
Authors: Lavery J. Patrick 
Published: September 2009

AbstractThe placenta is a marker of biologic events that occur during pregnancy. Placental pathologic examination gives insight to pregnancy‐related insults, which affect the newborn at and after birth. Clinicians and risk managers can use this information to identify the cause of newborn complications in cases suggested to be birth‐related injuries.
The impact of inefficient clinical diagnosis on the cost of managing low back pain
Authors: Gracovetsky Serge A. , Marriott Anne , Richards Mark P. , Newman Nicholas M. , Asselin Steeve 
Published: September 2009

AbstractThe clinical examination remains the pivotal factor in evaluating low back pain (LBP) for decisions concerning compensation and rehabilitation. Many practitioners believe it to be highly reliable, even though existing literature does not support this belief. Not only are there no data supporting the efficacy of clinical diagnosis for LBP, but also published data underscore its many inherent weaknesses. Healthcare risk managers need accurate clinical information to make decisions. If current clinical information is unreliable, then healthcare risk management strategies for LBP must be revised.
Planning for a bomb threat
Authors: Rozovsky Lorne E. 
Published: September 2009

AbstractA bomb threat must always be taken seriously. It is important to have specific response plans in place, especially in a healthcare facility, where patients may be particularly vulnerable both to danger and to the threat of danger. Also, the facility may be judged in the community by how it responds to a threat. A prudent risk manager will plan in advance, setting up a chain of command and specific procedures, and familiarizing all who take on bomb threat duties not only with their responsibilities, but also with one another. There should be a familiar and easy relationship among those required to work together in stressful situations.
The medicolegal risks of thermal injury during laparoscopic monopolar electrosurgery
Authors: Perantinides Paul G. , Tsarouhas Antonios P. , Katzman Van S. 
Published: September 2009

AbstractMedicolegal liability claims arising from minimally invasive surgeries are rapidly increasing. While the medical community appears aware of certain types of liability risks in this area, it often underappreciates the risks associated with monopolar laparoscopic electrosurgery. Jury verdicts and settlements help define this problem, which can lead to improved healthcare delivery and better outcomes for patients.
The dilemma over reprocessing single‐use medical devices
Authors: Parsons Malcolm S.“Duffy” 
Published: September 2009

AbstractMaking informed decisions about the reuse of single‐use medical devices requires considerable analysis, study and management buy‐in. This article addresses such issues as the prevalence of the practice, the changing standards and guidelines, institutional responsibilities, risk and insurance concerns and the ethical issues posed by the concept of reuse.
A case of munchausen syndrome by proxy presenting as a medical negligence action
Authors: Guarnero Ricardo A. 
Published: September 2009

AbstractThe parents of a child who was transported lifeless to a hospital initiated a medical negligence action. Only after discovery did it become clear that the mother, suffering from a disorder known as Munchausen syndrome by proxy, caused the death of the child. The case presented a number of complex evidentiary and litigation issues likely to be encountered by other medical‐negligence defense attorneys.
Downsizing, reengineering and patient safety: Numbers, newness and resultant risk
Authors: Knox G. Eric , Kelley Maureen , Simpson Kathleen Rice , Carrier Libby , Berry Dorothy 
Published: September 2009

AbstractDownsizing and reengineering are facts of life in contemporary healthcare organizations. In most instances, these organizational changes are undertaken in an attempt to increase productivity or cut operational costs with results measured in these terms. Less often considered are potential detrimental effects on patient safety or strategies, which might be used to minimize these risks.
Risk management at the heart of the matter: Addressing acute coronary care
Authors: Maley Robin A. 
Published: September 2009

AbstractEvery year, 540,000 patients enter a hospital for myocardial infarction. Of these, 4% to 13% will be misdiagnosed and 11%‐25% of them may die as a result. Missed diagnoses are the most expensive claims against emergency department physicians and account for 20% of all losses paid by them. A sound risk management program can save lives and dollars by supporting the effective and safe treatment of patients requiring acute coronary care.
Comparing risk management information: An invitation to disaster?
Authors: West John C. 
Published: September 2009

AbstractWhile many healthcare entities want to compare their risk management data with other entities, most such projects fail. This is usually due to weaknesses in terminology and differences in work practices. In addition, virtually all data in healthcare risk management are subjective and may readily be manipulated. To benchmark their data, facilities should be careful to understand what their data represents, and how the data compare with the data generated by other facilities. This usually requires an in‐depth review of work practices and procedures, coverages, and culture. Risk management data can be shared, but it must be done carefully.
Evaluating risk in human plasma transfusion
Authors: Darr Fred 
Published: September 2009

AbstractHuman plasma transfusion with fresh frozen plasma can be valuable in treating a variety of hemorrhagic disorders. Although safe in most cases, fresh frozen plasma poses some risk of viral infection via transfusion. New plasma preparations, using either quarantine or viral inactivation of pooled samples to improve safety, have been made available in the United States. Distinguishing characteristics include viral safety, availability, and cost. Risk managers should be aware of the range of plasma products, as well as the issues surrounding their use, in order to participate in organizational decision‐making regarding the recommendation of specific products.