bluuebunny/crossref_metadata_2025_split huggingface dataset:
Factors affecting outcome following treatment of patients with cavernous sinus meningiomas
Authors: Sughrue Michael E. , Rutkowski Martin J. , Aranda Derick , Barani Igor J. , McDermott Michael W. , Parsa Andrew T. 
Published: May 2010

Object
Although there is a considerable volume of literature available on the treatment of patients with cavernous sinus meningiomas (CSMs), most of the data regarding tumor control and survival come from case studies or single-institution series. The authors performed a meta-analysis of reported tumor control and survival rates of patients described in the published literature, with an emphasis on specific prognostic factors.

Methods
The authors systematically analyzed the published literature and found more than 3000 patients treated for CSMs. Separate meta-analyses were performed to calculate pooled rates of recurrence and cranial neuropathy after 1) gross-total resection, 2) subtotal resection without adjuvant postoperative radiotherapy or radiosurgery, and 3) stereotactic radiosurgery (SRS) alone. Results were expressed as pooled proportions, and random-effects models were used to incorporate any heterogeneity present to generate a pooled proportion. Individual studies were weighted using the inverse variance method, and 95% CIs for each group were calculated from the pooled proportions.

Results
A total of 2065 nonduplicated patients treated for CSM met inclusion criteria for the analysis. Comparisons of the 95% CIs for recurrence of these 3 cohorts revealed that SRS-treated patients experienced improved rates of recurrence (3.2% [95% CI 1.9–4.5%]) compared with either gross-total resection (11.8% [95% CI 7.4–16.1%]) or subtotal resection alone (11.1% [95% CI 6.6–15.7%]) (p < 0.01). The authors found that the pooled mixed-effects rate of cranial neuropathy was markedly higher in patients undergoing resection (59.6% [95% CI 50.3–67.5%]) than for those undergoing SRS alone (25.7% [95% CI 11.5–38.9%]) (p < 0.05).

Conclusions
Radiosurgery provided improved rates of tumor control compared with surgery alone, regardless of the subjective extent of resection.
Tractography of the amygdala and hippocampus: anatomical study and application to selective amygdalohippocampectomy
Authors: Colnat-Coulbois Sophie , Mok Kelvin , Klein Denise , Pénicaud Sidonie , Tanriverdi Taner , Olivier André 
Published: May 2010

Object
The aim of this study was to evaluate, using diffusion tensor tractography, the white matter fibers crossing the hippocampus and the amygdala, and to perform a volumetric analysis and an anatomical study of the connections of these 2 structures. As a second step, the authors studied the white matter tracts crossing a virtual volume of resection corresponding to a selective amygdalohippocampectomy.

Methods
Twenty healthy right-handed individuals underwent 3-T MR imaging. Volumetric regions of interest were manually created to delineate the amygdala, the hippocampus, and the volume of resection. White matter fiber tracts were parcellated using the fiber assignment for continuous tracking tractography algorithm. All fibers were registered with the anatomical volumes.

Results
In all participants, the authors identified fibers following the hippocampus toward the fornix, the splenium of the corpus callosum, and the dorsal hippocampal commissure. With respect to the fibers crossing the amygdala, the authors identified the stria terminalis and the uncinate fasciculus. The virtual resection disrupted part of the fornix, fibers connecting the 2 hippocampi, and fibers joining the orbitofrontal cortex. The approach created a theoretical frontotemporal disconnection and also interrupted fibers joining the temporal pole and the occipital area.

Conclusions
This diffusion tensor tractography study allowed for good visualization of some of the connections of the amygdala and hippocampus. The authors observed that the virtual selective amygdalohippocampectomy disconnected a large number of fibers connecting frontal, temporal, and occipital areas.
Changes in Body Fat Mass in Patients after Starting Peritoneal Dialysis
Authors: Choi Soo Jeong , Kim Na Ri , Hong Seong Ah , Lee Wan Bok , Park Moo Yong , Kim Jin Kuk , Hwang Seung Duk , Lee Hae Kyung 
Published: May 2010

Background Peritoneal dialysis (PD) is characterized by gain in fat mass. Visceral fat mass is associated with metabolic syndrome and atherosclerosis rather than subcutaneous fat mass. In addition, the change in visceral fat mass is a more reliable predictor of survival in PD patients. In this study, we prospectively examined serial changes in fat composition and nutritional status and analyzed factors associated with gain in fat mass in patients undergoing PD. Methods Body composition was assessed by bioelectric impedance analysis (BIA) and computed tomogram (CT). Nutrition status was assessed by Subjective Global Assessment (SGA), protein equivalent of nitrogen appearance (nPNA), serum albumin, C-reactive protein (CRP), and lipid profile. All measurements except BIA were performed on the seventh day and at 6 and 12 months after the start of PD. Results 60 patients (30 men; mean age 55.0 ± 12.5 years) were enrolled. Increase in body weight continued during the 12 months but visceral and subcutaneous fat mass increased during the first 6 months and decreased during the second 6 months. While hematocrit and serum albumin decreased during the first 6 months, they did not change during the second 6 months. Serum creatinine, total cholesterol, and triglyceride increased similarly to the weight pattern. While nPNA decreased during the 12 months, Kt/V, SGA, and CRP did not change. Patients that had more visceral fat mass at the start of PD had less gain of visceral fat mass during the first 6 months ( r = –0.821, p = 0.002). Patients that had more subcutaneous fat mass at the start of PD had less gain of subcutaneous fat mass ( r = –0.709, p = 0.015). The change in weight was not associated with the change in visceral or subcutaneous fat during the first 6 months. Conclusion Patients starting PD experience weight gain, including visceral and subcutaneous fat, during the first 6 months of PD. Patients with high baseline fat mass had less increase in fat mass than those with low baseline fat mass, regardless of visceral or subcutaneous fat mass.
Low Immunogenicity Allows Staphylococcus Epidermidis to Cause Pd Peritonitis
Authors: Jung Karin , Lüthje Petra , Lundahl Joachim , Brauner Annelie 
Published: May 2010

Background Peritonitis is a common and serious complication of peritoneal dialysis (PD). Coagulase-negative staphylococci from the patient's own skin flora are the most commonly found micro-organisms. Objective In the present study we aim to elucidate the immune response in the early stage of infection and to clarify the importance of bacterial attachment to fibrinogen. Methods Clinical Staphylococcus epidermidis isolates collected from PD peritonitis or the residential skin flora of healthy individuals were used to infect monocytes, macrophages, and peripheral blood mononuclear cells (PBMC) in the presence or absence of fibrinogen. The S. epidermidis strain HB (fbe+), expressing the fibrinogen-binding protein Fbe, and its isogenic mutant STO56 (fbe– ) were used to study the impact of Fbe during cell infection. Immune induction was measured as interleukin-8 (IL-8) production determined by ELISA. Modulation of CD11b/CD18 expression in neutrophils incubated in conditioned medium from these experiments was analyzed in order to judge the cellular response. Results S. epidermidis causing peritonitis was less immunogenic compared to strains belonging to the residential skin flora, as measured by IL-8 induction in monocytes and CD11b/CD18 expression in neutrophils. At low bacterial concentrations, attachment to fibrinogen was a prerequisite for an IL-8 induction in monocytes and PBMC. The fibrinogen-binding protein Fbe did not, however, influence immune induction under this condition. Conclusions We suggest that S. epidermidis strains may be able to cause clinical infection by evoking an inadequate immunological response in the early stage of infection. Bacterial attachment to fibrinogen is a relevant event during this phase but independent of the fibrinogen-binding protein Fbe.
NETLab: An Online Laboratory Management System
Authors: Maiti Ananda 
Published: May 2010

Online hardware-based educational laboratories are increasingly being deployed in traditional on-campus as well as Web-based distance-learning courses around the world. An online laboratory generally will consist of several hardware-based remote experiments. However, one particular experiment can be performed at a time by an individual student or a group of students which require a careful scheduling of the experiments. For the proper implementation of an online laboratory an efficient laboratory management system (LMS) is thus essential. Also for an online laboratory, the students need to fully understand the experimental system setup and feel comfortable as in an actual laboratory environment which, however, can be effectively done by adding suitable videos and animations etc. Besides, the students should be able to run the remote experiments, extract, save and analyze the data and submit laboratory reports online. The front end of the laboratory management system should be made browser-based so that one can use the laboratory facility from anywhere. Also, for the teachers, the laboratory management system should include an online evaluation for the quiz/viva-voce, checking experimental data, grading of submitted laboratory reports and feedback for the students.
In this paper, we describe the design and prototype implementation of an online laboratory management system (for use with shared hardware-based remote laboratory resources) which may be employed for running internet-based online laboratory courses for geographically dispersed Institutions.
Intrinsic and extrinsic contributors to subregional thalamic volume loss in multiple sclerosis
Authors: Krijnen Eva A. , Salim Karam Elsa , Russo Andrew W. , Lee Hansol , Chiang Florence L. , Schoonheim Menno M. , Huang Susie Y. , Klawiter Eric C. 
Published: May 2024

AbstractObjectiveTo evaluate the intrinsic and extrinsic microstructural factors contributing to atrophy within individual thalamic subregions in multiple sclerosis using in vivo high‐gradient diffusion MRI.MethodsIn this cross‐sectional study, 41 people with multiple sclerosis and 34 age and sex‐matched healthy controls underwent 3T MRI with up to 300 mT/m gradients using a multi‐shell diffusion protocol consisting of eight b‐values and diffusion time of 19 ms. Each thalamus was parcellated into 25 subregions for volume determination and diffusion metric estimation. The soma and neurite density imaging model was applied to obtain estimates of intra‐neurite, intra‐soma, and extra‐cellular signal fractions for each subregion and within structurally connected white matter trajectories and cortex.ResultsMultiple sclerosis‐related volume loss was more pronounced in posterior/medial subregions than anterior/ventral subregions. Intra‐soma signal fraction was lower in multiple sclerosis, reflecting reduced cell body density, while the extra‐cellular signal fraction was higher, reflecting greater extra‐cellular space, both of which were observed more in posterior/medial subregions than anterior/ventral subregions. Lower intra‐neurite signal fraction in connected normal‐appearing white matter and lower intra‐soma signal fraction of structurally connected cortex were associated with reduced subregional thalamic volumes. Intrinsic and extrinsic microstructural measures independently related to subregional volume with heterogeneity across atrophy‐prone thalamic nuclei. Extrinsic microstructural alterations predicted left anteroventral, intrinsic microstructural alterations predicted bilateral medial pulvinar, and both intrinsic and extrinsic factors predicted lateral geniculate and medial mediodorsal volumes.InterpretationOur results might be reflective of the involvement of anterograde and retrograde degeneration from white matter demyelination and cerebrospinal fluid‐mediated damage in subregional thalamic volume loss.
Breast Cancer Immune Landscape: Interplay Between Systemic and Local Immunity
Authors: Gerashchenko Tatiana , Frolova Anastasia , Patysheva Marina , Fedorov Anton , Stakheyeva Marina , Denisov Evgeny , Cherdyntseva Nadezda 
Published: May 2024

AbstractBreast cancer (BC) is one of the most common malignancies in women worldwide. Numerous studies in immuno‐oncology and successful trials of immunotherapy have demonstrated the causal role of the immune system in cancer pathogenesis. The interaction between the tumor and the immune system is known to have a dual nature. Despite cytotoxic lymphocyte activity against transformed cells, a tumor can escape immune surveillance and leverage chronic inflammation to maintain its own development. Research on antitumor immunity primarily focuses on the role of the tumor microenvironment, whereas the systemic immune response beyond the tumor site is described less thoroughly. Here, a comprehensive review of the formation of the immune profile in breast cancer patients is offered. The interplay between systemic and local immune reactions as self‐sustaining mechanism of tumor progression is described and the functional activity of the main cell populations related to innate and adaptive immunity is discussed. Additionally, the interaction between different functional levels of the immune system and their contribution to the development of the pro‐ or anti‐tumor immune response in BC is highlighted. The presented data can potentially inform the development of new immunotherapy strategies in the treatment of patients with BC.
Composition Dictates Octahedral Tilt and Photostability in Halide Perovskites
Authors: Iqbal Affan N. , Orr Kieran W. P. , Nagane Satyawan , Ferrer Orri Jordi , Doherty Tiarnan A. S. , Jung Young‐Kwang , Chiang Yu‐Hsien , Selby Thomas A. , Lu Yang , Mirabelli Alessandro J. , Baldwin Alan , Ooi Zher Ying , Gu Qichun , Anaya Miguel , Stranks Samuel D. 
Published: May 2024

AbstractHalide perovskites are excellent candidate materials for use in solar cell, LED, and detector devices, in part because their composition can be tuned to achieve ideal optoelectronic properties. Empirical efficiency optimization has led the field toward compositions rich in FA (formamidinium) on the A‐site and I on the X‐site, with additional small amounts of MA (methylammonium) or Cs A‐site cations and Br X‐site anions. However, it is not clear how and why the specific compositions of alloyed, that is, mixed component, halide perovskites relate to photo‐stability of the materials. Here, this work combines synchrotron grazing incidence wide‐angle X‐ray scattering, photoluminescence, high‐resolution scanning electron diffraction measurements and theoretical modelling to reveal the links between material structure and photostability. Namely, this work finds that increased octahedral titling leads to improved photo‐stability that is correlated with lower densities of performance‐harming hexagonal polytype impurities. These results uncover the structural signatures underpinning photo‐stability and can therefore be used to make targeted changes to halide perovskites, bettering the commercial prospects of technologies based on these materials.
Controlled Growth Lateral/Vertical Heterostructure Interface for Lithium Storage
Authors: Wang Tao , Li Mingsheng , Yao Li , Yang Wenlong , Li Yuliang 
Published: May 2024

AbstractArtificial heterostructures with structural advancements and customizable electronic interfaces are fundamental for achieving high‐performance lithium‐ion batteries (LIBs). Here, a design idea for a covalently bonded lateral/vertical black phosphorus (BP)‐graphdiyne oxide (GDYO) heterostructure achieved through a facile ball‐milling approach, is designed. Lateral heterogeneity is realized by the sp2‐hybridized mode P‐C bonds, which connect the phosphorus atoms at the edges of BP with the carbon atoms of the terminal acetylene in GDYO. The vertical connection of the heterojunction of BP and GDYO is connected by P‐O‐C bond. Experimental and theoretical studies demonstrate that BP‐GDYO incorporates interfacial and structural engineering features, including built‐in electric fields, chemical bond interactions, and maximized nanospace confinement effects. Therefore, BP‐GDYO exhibits improved electrochemical kinetics and enhanced structural stability. Moreover, through ex‐ and in‐situ studies, the lithiation mechanism of BP‐GDYO, highlighting that the introduction of GDYO inhibits the shuttle/dissolution effect of phosphorus intermediates, hinders volume expansion, provides more reactive sites, and ultimately promotes reversible lithium storage, is clarified. The BP‐GDYO anode exhibits lithium storage performance with high‐rate capacity and long‐cycle stability (602.6 mAh g−1 after 1 000 cycles at 2.0 A g−1). The proposed interfacial and structural engineering is universal and represents a conceptual advance in building high‐performance LIBs electrode.
Full‐Color Electrochromics with Donor‐Gradient Architectures for Chameleon‐Like Adaptive Camouflage
Authors: Li Ang , Zhuang Biying , Gong Hui , Xu Jinheng , Zhang Qianqian , Chen Xiaoqing , Zheng Zilong , Liu Jingbing , Wang Hao 
Published: May 2024

AbstractMulticolor electrochromics have emerged as a promising solution for achieving active color modulation akin to chameleon‐like adaptive camouflage. However, the development of electrochromics with full‐color tunability still remains challenging, given the weak molecular polarity of inherent active materials and the difficulty in forming polarizer orbitals under varying applied voltages. Employing molecular polarity adjustments, a novel electrochromic polymer is successfully developed with a donor‐gradient design of molecular architecture, enabling comprehensive full‐color tunability. The polymer demonstrates outstanding overall electrochromic performance, including fast switching (around 1.4 s), high coloration efficiency (395.1 cm2 C−1@550 nm) and excellent reversibility (over 92% retention after 5000 cycles). Leveraging the full‐color tunability and rapid response, the electrochromic polymer is further integrated with sensing and control modules to create an environmental adaptive camouflage prototype system capable of seamlessly blending colors with dynamic background environments. This work is expected to provide a straightforward approach for developing full‐color electrochromics for electrochromic camouflage applications.
Zeolitic Imidazolate Frameworks Based Anticancer Drug Delivery System Associated with Dual Action of Surface Charge and Lewis Base Ligand
Authors: Yang Wenjuan , Tian Lingling , Zhao Ning , Feng Lingyan , Zhou Bingpu , Zhu Yongheng , Gao Xinghua , Zhang Yuan 
Published: May 2024

AbstractZeolitic imidazole frameworks (ZIFs), which combine the favorable characteristics of tunable porosity, controlled structure, and facile functionalization, are explored as a novel class of nanocarriers for biomedical applications. In this study, different ZIF materials are investigated, including ZIF‐8, ZIF‐67, ZIF‐90, ZIF‐92, and ZIF‐108, with the same sodalite topology as the adenosine‐5′‐triphosphate (ATP)‐triggered drug delivery systems. Results indicated that ZIF‐90 and ZIF‐108 displayed good biological compatibility and efficiently accumulated in the mitochondria through competitive coordination between the metal nodes of the ZIFs and ATP, suggesting efficient intracellular delivery. With further interactions between these metal ions and ATP, the encapsulated drugs are released from the ZIF nanoparticles, thereby achieving optimal anti‐tumor activity. Through a systematic evaluation of the physicochemical properties of different ZIFs, it demonstrates that the surface charges of ZIFs have a significant impact on the cytotoxicity of cells, whereas the Lewis basicity of imidazole‐based ligands plays an essential role in the competitive coordination between the metal ions and ATP. These findings provide a potential method for screening ZIFs based nanocarriers with minimal toxicity and explain the different delivery efficiencies of these materials with similar topologies.
Utilization of aggregation‐induced emission materials in urinary system diseases
Authors: Xu Haodong , Chen Xin , Wang He , Wang Chaozhong , Guo Yunjie , Lin Yuxin , Huang Yuhua , Hou Jianquan , Wei Xuedong 
Published: May 2024

AbstractWith the development of aggregation‐induced emission (AIE) materials, the drawbacks of conventional fluorescence materials subjected to aggregation‐caused quenching (ACQ) have been resolved. This has allowed for the improvement of novel AIE fluorescent materials that exhibit enhanced photostability, a higher signal‐to‐noise ratio, and better imaging quality. Meanwhile, the enhanced phototherapeutic effect of AIE materials has garnered widespread attention in the realm of tumor treatment. The distinct physiological and anatomical characteristics of the urinary system make it suitable for the use of AIE materials. Additionally, AIE‐based phototherapy provides a superior solution to deal with the weaknesses of conventional treatments for urologic neoplasms. In this review, the scientific advancement on the use of AIE materials in urinary system diseases since the emergence of the AIE concept is reviewed in detail. The review highlights the promise of AIE materials for biomarkers detection, fluorescence imaging (FLI) in vivo and in vitro, AIE‐based phototherapy, and synergistic therapy from both diagnostic and therapeutic viewpoints. It is firmly believed that AIE materials hold immense untapped potential for the diagnosis and treatment of urologic disease, as well as all diseases of the human body.
Reviving Cost‐Effective Organic Cathodes in Halide‐Based All‐Solid‐State Lithium Batteries
Authors: Gao Yingjie , Fu Jiamin , Hu Yang , Zhao Feipeng , Li Weihan , Deng Sixu , Sun Yipeng , Hao Xiaoge , Ma Jinjin , Lin Xiaoting , Wang Changhong , Li Ruying , Sun Xueliang 
Published: May 2024

AbstractThe evolution of inorganic solid electrolytes has revolutionized the field of sustainable organic cathode materials, particularly by addressing the dissolution problems in traditional liquid electrolytes. However, current sulfide‐based all‐solid‐state lithium‐organic batteries still face challenges such as high working temperatures, high costs, and low voltages. Here, we design an all‐solid‐state lithium battery based on a cost‐effective organic cathode material phenanthrenequinone (PQ) and a halide solid electrolyte Li2ZrCl6. Thanks to the good compatibility between PQ and Li2ZrCl6, the PQ cathode achieved a high specific capacity of 248 mAh g−1 (96 % of the theoretical capacity), a high average discharge voltage of 2.74 V (vs. Li+/Li), and a good capacity retention of 95 % after 100 cycles at room temperature (25 °C). Furthermore, the interactions between the high‐voltage carbonyl PQ cathode and both sulfide and halide solid electrolytes, as well as the redox mechanism of the PQ cathode in all‐solid‐state batteries, were carefully studied by a variety of advanced characterizations. We believe such a design and the corresponding investigations into the underlying chemistry give insights for the further development of practical all‐solid‐state lithium‐organic batteries.
Enantioselective Dearomatization of Pyridinium Salts by Copper‐Catalyzed C4‐Selective Addition of Silicon Nucleophiles
Authors: Xiao Yao , Zhao Zhi‐Yuan , Kemper Sebastian , Irran Elisabeth , Oestreich Martin 
Published: May 2024

AbstractA copper‐catalyzed C4‐selective addition of silicon nucleophiles released from an Si−B reagent to prochiral pyridinium triflates is reported. The dearomatization proceeds with excellent enantioselectivity using Cu(CH3CN)4PF6 as the precatalyst and (R,R)‐Ph‐BPE (1,2‐bis[(2R,5R)‐2,5‐diphenylphospholan‐1‐yl]ethane) as the chiral ligand. A carbonyl group at C3 is required for this, likely acting a weak donor group to preorganize and direct the nucleophilic attack towards C4. The resulting 4‐silylated 1,4‐dihydropyridines can be further converted into functionalized piperidine derivatives.