bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cardinality of height function’s range in case of maximally many rectangular islands — computed by cuts
Authors: Horváth Eszter , Šešelja Branimir , Tepavčević Andreja 
Published: August 2012

Abstract
We deal with rectangular m×n boards of square cells, using the cut technics of the height function. We investigate combinatorial properties of this function, and in particular we give lower and upper bounds for the number of essentially different cuts. This number turns out to be the cardinality of the height function’s range, in case the height function has maximally many rectangular islands.
Clonal Analysis of the Quasispecies of Antiviral-Resistant HBV Genomes in Patients with Entecavir Resistance during Rescue Treatment and Successful Treatment of Entecavir Resistance with Tenofovir
Authors: Karatayli Ersin , Idilman Ramazan , Karatayli Senem C , Cevik Emrah , Yakut Mustafa , Seven Gülseren , Kabaçam Gökhan , Bozdayi A Mithat , Yurdaydin Cihan 
Published: August 2012

Background Clonal analysis of quasispecies of resistant HBV genomes in patients with entecavir (ETV) resistance receiving lamivudine (3TC) plus adefovir (ADV) rescue therapy has never been performed. Methods A sample of 10 patients with ETV resistance who were switched to 3TC+ADV treatment were analysed for changes in viral quasispecies. Serum samples at baseline, and at months 3 and 6 of 3TC+ADV treatment could be clonally analysed in 7 of 10 patients; 3–82 clones per sample (total 1,068 clones, mean 63) were sequenced. Results 3TC+ADV therapy led to a modest decline in HBV DNA. Almost all clones had L180M and M204V 3TC resistance mutations before and during combination therapy. All clones had ≥1 of the S202G, T184F, T184A, T184L, T184I and M250V ETV resistance mutations. The percentages of detected clones bearing 3TC (rtL180M and rtM204V) and ETV mutations did not change with rescue 3TC+ADV therapy. In 7 of 8 patients with detectable HBV DNA (median 5.17 log10 copies/ml) after a median 24 months of ADV therapy, HBV DNA became undetectable with 3TC plus tenofovir after 6 months of treatment. Conclusions In patients with ETV resistance tenofovir is effective. Clonal analysis data indicate no selection of specific HBV mutants during rescue 3TC+ADV.
Elevated D-Dimer is Independently Associated with Endothelial Dysfunction: A Cross-Sectional Study in HIV-Infected Adults on Antiretroviral Therapy
Authors: Hileman Corrilynn O , Longenecker Chris T , Carman Teresa L , Milne Ginger L , Labbato Danielle E , Storer Norma J , White Cynthia A , McComsey Grace A 
Published: August 2012

Background D-Dimer elevations have been associated with a striking increase in mortality in HIV-infected patients. However, D-Dimer has not been directly linked to endothelial dysfunction in HIV. Methods In this cross-sectional study, we used flow-mediated dilation (FMD) of the brachial artery to measure endothelial function and several biomarkers to measure systemic inflammation and coagulation activation in HIV-infected adults on stable antiretroviral therapy with HIV-1 RNA levels <400 copies/ml. Multivariable linear regression was used to model FMD by these markers, traditional cardiovascular risk factors and HIV-related characteristics. Results Analysis included 98 subjects (88% male, median age 47.5 years, CD4+ T-cells 578.5 cells/mm3); all on ART (52% on protease inhibitors). The only factors independently associated with FMD were D-Dimer and body mass index. Conclusions We show for the first time an independent association between D-Dimer and endothelial dysfunction in virologically suppressed, HIV-infected adults on stable antiretroviral therapy, potentially explaining the link between D-Dimer and mortality in HIV.
Novel Humanized and Highly Efficient Bispecific Antibodies Mediate Killing of Prostate Stem Cell Antigen-Expressing Tumor Cells by CD8+ and CD4+ T Cells
Authors: Feldmann Anja , Arndt Claudia , Töpfer Katrin , Stamova Slava , Krone Franziska , Cartellieri Marc , Koristka Stefanie , Michalk Irene , Lindemann Dirk , Schmitz Marc , Temme Achim , Bornhäuser Martin , Ehninger Gerhard , Bachmann Michael 
Published: August 2012

AbstractProstate cancer is the most common noncutaneous malignancy in men. The prostate stem cell Ag (PSCA) is a promising target for immunotherapy of advanced disease. Based on a novel mAb directed to PSCA, we established and compared a series of murine and humanized anti-CD3–anti-PSCA single-chain bispecific Abs. Their capability to redirect T cells for killing of tumor cells was analyzed. During these studies, we identified a novel bispecific humanized Ab that efficiently retargets T cells to tumor cells in a strictly Ag-dependent manner and at femtomolar concentrations. T cell activation, cytokine release, and lysis of target cells depend on a cross-linkage of redirected T cells with tumor cells, whereas binding of the anti-CD3 domain alone does not lead to an activation or cytokine release. Interestingly, both CD8+ and CD4+ T cells are activated in parallel and can efficiently mediate the lysis of tumor cells. However, the onset of killing via CD4+ T cells is delayed. Furthermore, redirecting T cells via the novel humanized bispecific Abs results in a delay of tumor growth in xenografted nude mice.
“Linked data” – dados interligados - e interoperabilidade entre arquivos, bibliotecas e museus na web
Authors: Marcondes Carlos Henrique 
Published: August 2012

http://dx.doi.org/10.5007/1518-2924.2012v17n34p171 Catálogos Web em sistemas de arquivos, bibliotecas e museus são hoje recursos informacionais fechados, usando tecnologias, padrões e interfaces de próprios, não permitindo navegar de outros recursos para dentro dos catálogos e vice-versa. Tecnologias “Linked Data” – dados interligados -, parte da proposta da Web Semântica, oferecem a possibilidade de interligar recursos informacionais Web através de “links” semânticos, permitindo aos usuários uma navegação natural e intuitiva, seguindo este “links”, por estes recursos, independentemente de interfaces de consulta específicas. O objetivo deste artigo é identificar e discutir as potencialidades oferecidas pelas tecnologias da Web Semântica, em especial, “Linked Open Data”, para que arquivos, bibliotecas e museus disponibilizem e tornem interoperáveis seus acervos na Web. Será utilizada metodologia de caráter qualitativo, do tipo “levantamento do estado da arte”, tendo como método a pesquisa bibliográfica, a visita a “sites” de interesse e a análise do material levantado.
FACTORES A CONSIDERAR EN LA REGENERACIÓN NATURAL DEL BOSQUE TROPICAL SECO EN NICARAGUA
Authors: Gonzalez-Rivas Benigno , Castro-Marín Guillermo 
Published: August 2012

En el presente estudio se analizó el banco de semillas del suelo en un ecosistema de bosque seco secundario en Nandarola, Nandaime, departamento de Granada. La investigación tuvo por objetivos estimar composición florística y densidad de semillas presentes en el banco de semillas de suelo. Se recolectaron muestras de suelo que incluían la capa litter y tres capas de suelo mineral sucesivas (de 0-3, 3-6 y 6-9 cms). El número total de especies presente en el banco de semillas del suelo fue de 33 especies, distribuidas en 23 familias. El número total de semillas presente fue 240 semillas por metro cuadrado. Tambien se hizo otro estudio sobre la regeneración natural de tres especies: Lysiloma divaricatum (Jacq.), Tabebuia ochracea (Cham.) and Lonchocarpus minimiflorus (Donn. Sm.) en un periodo de tres años en la Reserva Natural de Chacocente. Los resultados obtenidos señalan que la densidad de las especies varía significativamente durante el periodo de estudio. La regeneración natural por si sola no es suficiente para mantener el número adecuado de plántulas, por lo tanto se deben de tomar medidas para incrementar la regeneración de las especies. DOI: http://dx.doi.org/10.5377/calera.v11i16.747 La Calera Vol. 11, No 16 p. 5-11/junio 2011
CARACTERIZACIÓN DE 16 GENOTIPOS DE LEGUMINOSAS HERBÁCEAS ASOCIADO CON MAÍZ EN NIQUINOHOMO Y MANAGUA
Authors: Pérez Emilio , Bonilla Glenda , Ruiz Carlos , Núñez-Martínez José Aurélio , Martínez-Cruz Manuel Luis 
Published: August 2012

Este ensayo experimental documenta el comportamiento agronómico general de leguminosas herbáceas asociadas con maíz, bajo manejo en dos ambientes ecológicos diferentes de Nicaragua: Finca Santa Rosa, Sabana Grande, Managua y el Rancho Agropecológico en Especies Menores Ebenezer, RAEME, Niquinohomo, Masaya, para tal fin se emplearon como tratamientos 7 especies y 16 variedades de leguminosas herbáceas asociadas con maíz (Zea mays), variedad NB6, más maíz establecido en monocultivo, a los cuales se les analizó mediante las variables germinación, altura de la planta, diámetro del tallo, cobertura, presencia de daño foliar por insectos, presencia de malezas, porcentaje de materia seca, kg de materia seca por hectárea, número de nódulos, peso de raíz y porcentaje de Nitrógeno en biomasa de las leguminosas. El diseño del ensayo experimental constó de tres bloques al azar, dispuestos en forma perpendicular entre sí, cada bloque fue dividido en 17 parcelas. Al analizar los resultados se encontró que en la Finca Santa Rosa Vigna unguiculata verde brasil (vun1) y en RAEME, Vigna unguiculata 284/2 (Vun3) fueron la s leguminosas que presentaron mejor comportamiento, en relación al maíz, en la Finca Santa Rosa presentó mejor comportamiento al estar asociado con Vigna unguiculata 131-2 (Vun5), en RAEME, fue el maíz asociado con Centrosema plumieri (Cp). Así mismo los resultados indican que al asociar el maíz con leguminosas se obtienen mejores resultados que estando solo. Para ambos sitios se determinó que el mejor asocio fue maíz - Vigna unguiculata verde brasil (vun1), ya que proporciona para ambas especies calificaciones similares, demostrando un equilibrio entre los dos cultivos. DOI: http://dx.doi.org/10.5377/calera.v11i16.751 La Calera Vol. 11, No 16 p. 43-49/junio 2011
Herringbone and Helical Self‐Assembly of π‐Conjugated Molecules in the Solid State through CH/π Hydrogen Bonds
Authors: Goel Mahima , Jayakannan Manickam 
Published: August 2012

AbstractSelf‐organization of organic molecules through weak noncovalent forces such as CH/π interactions and creation of large hierarchical supramolecular structures in the solid state are at the very early stage of research. The present study reports direct evidence for CH/π interaction driven hierarchical self‐assembly in π‐conjugated molecules based on custom‐designed oligophenylenevinylenes (OPVs) whose structures differ only in the number of carbon atoms in the tails. Single‐crystal X‐ray structures were resolved for these OPV synthons and the existence of long‐range multiple‐arm CH/π interactions was revealed in the crystal lattices. Alignment of these π‐conjugated OPVs in the solid state was found to be crucial in producing either right‐handed herringbone packing in the crystal or left‐handed helices in the liquid‐crystalline mesophase. Pitch‐ and roll‐angle displacements of OPV chromophores were determined to trace the effect of the molecular inclination on the ordering of hierarchical structures. Furthermore, circular dichroism studies on the OPVs were carried out in the aligned helical structures to prove the existence of molecular self‐assembly. Thus, the present strategy opens up new approaches in supramolecular chemistry based on weak CH/π hydrogen bonding, more specifically in π‐conjugated materials.
Synthesis, Characterisation and Electrical Properties of Supramolecular DNA‐Templated Polymer Nanowires of 2,5‐(Bis‐2‐thienyl)‐pyrrole
Authors: Watson Scott M. D. , Hedley Joseph H. , Galindo Miguel A. , Al‐Said Said A. F. , Wright Nick G. , Connolly Bernard A. , Horrocks Benjamin R. , Houlton Andrew 
Published: August 2012

AbstractSupramolecular polymer nanowires have been prepared by using DNA‐templating of 2,5‐(bis‐2‐thienyl)‐pyrrole (TPT) by oxidation with FeCl3 in a mixed aqueous/organic solvent system. Despite the reduced capacity for strong hydrogen bonding in polyTPT compared to other systems, such as polypyrrole, the templating proceeds well. FTIR spectroscopic studies confirm that the resulting material is not a simple mixture and that the two types of polymer interact. This is indicated by shifts in bands associated with both the phosphodiester backbone and the nucleobases. XPS studies further confirm the presence of DNA and TPT, as well as dopant Cl− ions. Molecular dynamics simulations on a [{dA24:dT24}/{TPT}4] model support these findings and indicate a non‐coplanar conformation for oligoTPT over much of the trajectory. AFM studies show that the resulting nanowires typically lie in the 7–8 nm diameter range and exhibit a smooth, continuous, morphology. Studies on the electrical properties of the prepared nanowires by using a combination of scanned conductance microscopy, conductive AFM and variable temperature two‐terminal I–V measurements show, that in contrast to similar DNA/polymer systems, the conductivity is markedly reduced compared to bulk material. The temperature dependence of the conductivity shows a simple Arrhenius behaviour consistent with the hopping models developed for redox polymers.
ChemInform Abstract: A Cyano‐Bridged Vanadium—Niobium Bimetal Assembly Exhibiting a High Curie Temperature of 210 K.
Authors: Imoto Kenta , Takemura Miho , Tokoro Hiroko , Ohkishi Shin‐ichi 
Published: August 2012

AbstractK0.59VII1.59VIII0.41 [NbIV(CN)8] ·(SO4)0.50·6.9H2O precipitates from an aqueous solution of K4[Nb(CN)8], VSO4, and VCl3 at ‐3 °C.
ChemInform Abstract: Alternate Layered Nanostructures of Metal Oxides by a Click Reaction.
Authors: Mochizuki Dai , Kumagai Kozue , Maitani Masato M. , Wada Yuji 
Published: August 2012

AbstractAn alternating multilayer of titanium and tungsten oxides is synthesized by modifying layered titanium oxide with an alkene group and layered tungsten oxide with a thiol group, and causing a thiol—ene (click) reaction.
ChemInform Abstract: Synthesis, Characterization, and Crystal Structures of Uranyl Compounds Containing Mixed Chromium Oxidation States.
Authors: Unruh Daniel K. , Quicksall Andrew , Pressprich Laura , Stoffer Megan , Qiu Jie , Nuzhdin Kirill , Wu Weiqiang , Vyushkova Mariya , Burns Peter C. 
Published: August 2012

AbstractThe mixed‐valence chromium uranyl compounds (IV), (VI), and (VIII) are characterized by single crystal XRD, IR spectroscopy, XANES, and EPR spectroscopy.
ChemInform Abstract: Diarylprolinol in an Asymmetric Aldol Reaction of an α‐Alkyl‐α‐oxo Aldehyde as an Electrophile.
Authors: Hayashi Yujiro , Yasui Yusuke , Kojima Masahiro , Kawamura Tsuyoshi , Ishikawa Hayato 
Published: August 2012

AbstractA convenient synthesis of γ‐oxo‐β‐hydroxy aldehydes via an asymmetric aldol reaction proceeding with excellent anti‐ and diastereoselectivity and enantioselectivity is reported.
ChemInform Abstract: Controlled Reactions of 2,3‐Allenoates with a 1,3‐Diketone Catalyst Effect.
Authors: Fang Zhao , Fu Chunling , Ma Shengming 
Published: August 2012

AbstractThe reaction of 2,3‐allenoates with 1,3‐diketones furnishes either addition products or furan derivatives depending on the reaction conditions.
ChemInform Abstract: Platinum(II) Diphosphinamine Complexes for the Efficient Hydration of Alkynes in Micellar Media.
Authors: Trentin Francesco , Chapman Andrew M. , Scarso Alessandro , Sgarbossa Paolo , Michelin Rino A. , Strukul Giorgio , Wass Duncan F. 
Published: August 2012

AbstractA monomeric bis‐cationic complex bearing a small bite angle PNP ligand allows for highly selective alkyne hydration in water/surfactant media.
ChemInform Abstract: Synthesis and Applications of Fe3O4‐Diisopropylaminoacetamide as a Versatile and Reusable Magnetic Nanoparticle Supported N,N‐Diisopropylethylamine Equivalent.
Authors: Rattanaburi Parintip , Khumraksa Bannarak , Pattarawarapan Mookda 
Published: August 2012

AbstractPISR is used as magnetically recoverable heterogeneous base for the reaction of activated halides with primary and secondary amines.
ChemInform Abstract: Efficient Copper(II)‐Catalyzed Transamidation of Non‐Activated Primary Carboxamides and Ureas with Amines.
Authors: Zhang Min , Imm Sebastian , Baehn Sebastian , Neubert Lorenz , Neumann Helfried , Beller Matthias 
Published: August 2012

AbstractFor the first time a straightforward copper‐catalyzed transamidation method is developed.
ChemInform Abstract: Green Synthesis of Novel Chalcone and Coumarin Derivatives via Suzuki Coupling Reaction.
Authors: Vieira Lucas C. C. , Paixao Marcio Weber , Correa Arlene G. 
Published: August 2012

AbstractDifferent brominated and iodinated chalcones as well a the iodocoumarin (IX) are investigated as substrates.
ChemInform Abstract: Facile Synthesis of Functionalized Bis(arylethynyl)benzene Derivatives via sila‐Sonogashira Reaction.
Authors: Zhou Zhang‐Lin , Zhao Lihua , Zhang Sean , Vincent Kent , Lam Sity , Henze Dick 
Published: August 2012

AbstractCross coupling of dihaloarenes (I) with silylacetylenes (II) proceeds smoothly under modified Sonogashira conditions to chemoselectively afford bis(acetylenyl)arenes (III) in good yields.
ChemInform Abstract: Enantioselective 5‐endo‐Dig Carbocyclization of β‐Ketoesters with Internal Alkynes Employing a Four‐Component Catalyst System.
Authors: Suzuki Satoru , Tokunaga Etsuko , Reddy Dhande Sudhakar , Matsumoto Takashi , Shiro Motoo , Shibata Norio 
Published: August 2012

AbstractThe first practical method for the 5‐endo‐dig variant of the Conia‐ene carbocyclization is developed.
ChemInform Abstract: Efficient Aziridination of α,β‐Unsaturated Ketones with O‐(2,4‐Dinitrophenyl)‐hydroxylamine.
Authors: Wang Jin‐jia , Lao Jin‐hua , Li Xue‐ming , Lu Rui‐jiong , Miao Hui , Yan Ming 
Published: August 2012

AbstractTitle aziridination reaction of alkenyl aryl ketones (I) provides trans‐disubstituted aziridines (II), exclusively.
ChemInform Abstract: Tetrahydropyridinium Bromide: Useful Synthon to Functionalized Pyrrolidines.
Authors: Guideri Luca , Noschese Rossella , Ponticelli Fabio 
Published: August 2012

AbstractPiperidinium salt (I) undergoes ring contraction with a range of nucleophiles to furnish 2,2‐disubstituted pyrrolidines.
ChemInform Abstract: Dehydrogenative Synthesis of C3‐Azolylindoles via Copper‐Promoted Annulative Direct Coupling of o‐Alkynylanilines.
Authors: Oda Yoshiro , Matsuyama Naoto , Hirano Koji , Satoh Tetsuya , Miura Masahiro 
Published: August 2012

Abstracto‐Alkynylanilines bearing a suitable leaving group (generally o‐fluorobenzoyl) at the nitrogen are coupled with oxadiazoles to produce N‐unsubstituted indoles directly.
ChemInform Abstract: [2 + 2] Photocycloadditions of Thiomaleimides.
Authors: Tedaldi Lauren M. , Aliev Abil E. , Baker James R. 
Published: August 2012

AbstractThe photocycloaddition reaction of thiomaleimides (I) and (XIII) leads to dimers (II) and (XIV)/(XV), resp., in quantitative yields.
ChemInform Abstract: An Efficient One‐Pot Synthesis of 3,5‐Disubstituted 1H‐Pyrazoles.
Authors: Wu Lei‐Lei , Ge Yi‐Cen , He Ting , Zhang Lei , Fu Xing‐Li , Fu Hai‐Yan , Chen Hua , Li Rui‐Xiang 
Published: August 2012

AbstractThe three‐component process allows the access to pyrazole structures bearing functionalized aryl substituents.
ChemInform Abstract: 2‐Amino‐X‐nitrobenzimidazoles as Precursors of Food‐Borne Carcinogens: A New Approach to IQ Synthesis.
Authors: Bella Maros , Milata Viktor , Larina Lyudmila I. 
Published: August 2012

AbstractThe nitro‐substituted aminobenzimidazoles (III) are prepared as potential precursors for food‐borne carcinogens or their analogues by cyclization of nitrophenylenediamines (I) with cyanogen bromide (II).
ChemInform Abstract: Oxidative Transformation of N‐Substituted 2‐Aminophenols to 2‐Substituted Benzoxazoles Catalyzed by Polymer‐Incarcerated and Carbon‐Stabilized Platinum Nanoclusters.
Authors: Yoo Woo‐Jin , Yuan Hao , Miyamura Hiroyuki , Kobayashi Shu 
Published: August 2012

AbstractSequential aerobic oxidation—enolization—oxidative cyclization reaction of N‐substituted o‐aminophenols (I) and (III) proceeds smoothly under catalysis of Pt nanoparticles stabilized by carbon black and a styrene‐derived polymer.
ChemInform Abstract: Asymmetric Synthesis of Dihydropyranones from Ynones by Sequential Copper(I)‐Catalyzed Direct Aldol and Silver(I)‐Catalyzed Oxy‐Michael Reactions.
Authors: Shi Shi‐Liang , Kanai Motomu , Shibasaki Masakatsu 
Published: August 2012

AbstractA facile and general method for the title synthesis is developed.
ChemInform Abstract: One‐Pot Three‐Component Highly Selective Synthesis of Homoallylboronates by Using Metal‐Free Catalysis.
Authors: Ibrahem Ismail , Breistein Palle , Cordova Armando 
Published: August 2012

AbstractThe first one‐pot three‐component reaction of α,β‐unsaturated aldehydes with bis(pinacolatoborane) (II) and triphenylphosphoranylideneacetate (III) is presented, which proceeds readily in the presence of catalytic amounts of N,N′‐dicyclohexylimidazolium salt.
ChemInform Abstract: New Method for the Synthesis of Ether Derivatives of Artemisinin.
Authors: Bora Pranjal P. , Baruah Nabajyoti , Bez Ghanashyam , Barua Nabin C. 
Published: August 2012

AbstractEtherification of dihydroartemisinin with a wide variety of alcohols is effectively catalyzed by dodecatungstophosphoric acid hydrate.
ChemInform Abstract: Syntheses Utilizing n‐Perfluoroalkyl Iodides [RFI, CnF2n+1‐I] 2000—2010
Authors: Murphy Peter M. , Baldwin Christopher S. , Buck Robert C. 
Published: August 2012

AbstractReview: in free‐radical reactions, Grignard anion additions to ketones and aldehydes etc.; 231 refs.
ChemInform Abstract: Olefin Metathesis as Key Step in the Synthesis of Bioactive Compounds. Challenges in the Total Synthesis of (‐)‐Kendomycin
Authors: Bicchielli Dario , Borguet Yannick , Delaude Lionel , Demonceau Albert , Dragutan Ileana , Dragutan Valerian , Hans Morgan , Jossifov Christo , Nicks Francois , Willem Quentin 
Published: August 2012

AbstractReview: 78 refs.
ChemInform Abstract: Proton‐Coupled Electron Transfer
Authors: Weinberg David R. , Gagliardi Christopher J. , Hull Jonathan F. , Murphy Christine Fecenko , Kent Caleb A. , Westlake Brittany C. , Paul Amit , Ess Daniel H. , McCafferty Dewey Granville , Meyer Thomas J. 
Published: August 2012

AbstractReview: 590 refs.