bluuebunny/crossref_metadata_2025_split huggingface dataset:
Constructing Multi‐Functional Polymeric‐Termination Surface Enables High‐Performance Flexible Perovskite LEDs
Authors: Liu Chunyu , Zhang Dezhong , Sun Jiayun , Li Dongyu , Xiong Qi , Lyu Benzheng , Guo Wenbin , Choy Wallace C. H. 
Published: May 2024

AbstractFlexible perovskite light‐emitting diodes (f‐PeLEDs) have attracted increasing interest to realize true‐color, low‐cost, and light‐weight wearable optoelectronic and flexible display applications. However, their external quantum efficiency (EQE) and mechanical stability lag far behind because of the inherent surface and brittle issues of polycrystalline perovskite films. In this work, a multi‐functional polymeric‐termination surface of perovskite film is constructed for achieving efficient and mechanically stable f‐PeLEDs. It takes the roles to not only reduce defects through equipping coordination groups to improve emission properties, but also optimize film morphology and eliminate pinholes to solve the long‐standing issue of leakage current. Meanwhile, the polymeric‐termination surface with anchoring points and polymeric soft chains on perovskites demonstrates synergetic effects beyond the corresponding functional group‐only or polymer‐only strategies in reducing the Young's modulus and improving the mechanical flexibility. Ultimately, the record EQE of 22.1% and significantly enhanced mechanical stability of maintaining 82% of the initial performance after 2000 bending cycles with radius of 5 mm are achieved in pure‐green f‐PeLEDs. The work paves the way for the development of high‐performance flexible optoelectronic devices.
Resolving the Amino Acid Sequence of Aβ1‐42 at the Single‐Residue Level Using Subnanopores in Ultrathin Films
Authors: Chen Le , Meng Bin , Xie Yong , Yao Ziyang , Chen Haobin , Dong Zhuxin 
Published: May 2024

AbstractProteoforms are proteins derived from highly related genes or post translational modifications (PTMs) of the same protein. They share extremely similar primary structures but have varying functions. Unfortunately, protein de novo sequencing including specific PTM/mutation detection is still challenging. Herein, a nanopore‐based technique is reported to resolve the amino acid order of amyloid‐β (Aβ1‐42) with site specificity. Subnanopores are sputtered in 5 nm‐thick inorganic membranes with a sensing depth of 0.66 nm inferred by finite element analysis. Denatured molecules at 0.45 ng mL−1 translocate through subnanopores while the current traces are sampled at 500 kHz with rms noise <15 pA. Hundreds of blockades are clustered using machine learning, and multiple blockades are averaged to establish current consensus. Consensus traces strongly correlate with a linear model of amino acid volume of Aβ1‐42 at single residue resolution, with Pearson Correlation Coefficients (PCCs) of 0.81 ± 0.03 and 0.92 ± 0.03 before and after dynamic time warping (DTW). A scrambled version of Aβ1‐42 is tested for validation purposes. Deep learning classification reveals that different polypeptides generate distinct translocation fluctuating patterns, but variations become imperceptible for the same species measured across nanopores (Area Under the Curve, AUC 0.93 ± 0.05 vs 0.64 ± 0.12). Lastly, important PTMs and mutations are site‐specifically located along the primary structure, implying new potential clinical applications.
Microenvironment Reconstitution‐Induced Collaborative Oxyanions‐Vacancies Engineering for Enhanced High‐Mass‐Loading Energy Storage
Authors: Sun Mingming , Guo Wei , Wang Jinxin , Zhang Qiuyu 
Published: May 2024

AbstractPerformance breakthrough of energy‐storage electrodes under commercial‐level mass loading (≥10 mg cm−2) are highly pursued but restricted by sluggish mass/charge transfer rates and kinetically unfavorable reaction sites. In response, through electrochemical microenvironment reconstitution, these limitations are broken by engineering synergy between vacancies and oxyanions in the active matrix (Rec‐NiCoExch), which showcases a record‐level areal capacitance of 10.9 C cm−2 with a high mass loading of 20 mg cm−2 and a retention of 72% at 100‐fold current density. Such a design further endows the hybrid supercapacitor with an areal capacity of 20.9 C cm−2 and an energy density of 4.6 mWh cm−2, outperforming most of the benchmark results. Theoretical calculation reveals that in situ evolved oxyanions not only act as the effective adsorption sites but also secure the oxygen vacancies, enabling the potential synergy toward improved electronic conductivity and enhanced reactivity of Ni sites. As a proof‐of‐concept, the as‐assembled quasi‐solid‐state micro‐supercapacitor deliveries an ultrahigh energy density of 111.5 µWh cm−2 and presents great potential in intermittent energy storage by the solar panel‐supercapacitor‐LED system. This work offers insights for constructing commercial‐level energy‐storage electrodes by mastering surface/interface engineering for practical applications.
Artificial Spores as Multi‐Functional Biocatalysts to Perform Biosynthetic Cascades
Authors: Iturralde Maialen , Ripoll Magdalena , Silvio Desiré di , Gallego Marta , Grajales‐Hernández Daniel A. , López Xabier , Betancor Lorena , López‐Gallego Fernando 
Published: May 2024

AbstractCells exhibit diverse structural formations such as biofilms and spores, enabling them to acquire novel functionalities. Many of these structures display biomacromolecules, including enzymes, tethered to cell walls to support various extracellular processes. Alternatively, encapsulating single cells with polymer coatings offers a strategy that circumvents the need for genetic engineering while imparting artificial functionalities to cells. Here, a universal method is presented for encapsulating single gram‐negative microbes with polymeric coatings based on the ancestral gall ink formed by tannic acid‐iron complexes. As a result, synthetic spores are achieved that selectively bind His‐tagged enzymes through the formation of unprecedented galloyl/imidazole‐Fe2+ complexes via ligand substitution demonstrated by density functional theory. These synthetic spores with a thickness of 41.5 ± 4.2 nm and a stiffness of 6.0 ± 3.5 GPa serve as biocatalytic materials for the one‐pot oxidative amination of diols into amino alcohols, facilitated by the cooperative catalysis between intracellular endogenous or recombinant oxidoreductases, and an extracellular transaminase from Pseudomonas fluorescens displayed at the spore surface. These spores maintain their performance in three consecutive batch cycles. Integrating isolated enzymes onto the surface of engineered microbes coated with polymers offers novel opportunities for synthetic biology, advancing the efficiency of biosynthetic cascades in solid‐state environments.
Nanozyme‐Incorporated Microneedles for the Treatment of Chronic Wounds
Authors: Hu Zhiyuan , Shan Jie , Cui Yuyu , Cheng Liang , Chen Xu‐Lin , Wang Xianwen 
Published: May 2024

AbstractAcute wounds are converted to chronic wounds due to advanced age and diabetic complications. Nanozymes catalyze ROS production to kill bacteria without causing drug resistance, while microneedles (MNs) can break through the skin barrier to deliver drugs effectively. Nanozymes can be intergrateded into MNs delivery systems to improve painless drug delivery. It can also reduce the effective dose of drug sterilization while increasing delivery efficiency and effectively killing wounded bacteria while preventing drug resistance. This paper describes various types of metal nanozymes from previous studies and compares their mutual enhancement with nanozymes. The pooled results show that the MNs, through material innovation, are able to both penetrate the scab and deliver nanozymes and exert additional anti‐inflammatory and bactericidal effects. The catalytic effect of some of the nanozymes can also accelerate the lysis of the MNs or create a cascade reaction against inflammation and infection. However, the issue of increased toxicity associated with skin penetration and clinical translation remains a challenge. This study reviews the latest published results and corresponding challenges associated with the use of MNs combined with nanozymes for the treatment of wounds, providing further information for future research.
Developing MiR‐133a Zipper Nanoparticles for Targeted Enhancement of Thermogenic Adipocyte Generation
Authors: Yi Sang Ah , Pongkulapa Thanapat , Nevins Sarah , Goldston Li Ling , Chen Meizi , Lee Ki‐Bum 
Published: May 2024

AbstractExisting delivery methods for RNAi therapeutics encounter challenges, including stability, specificity, and off‐target effects, which restrict their clinical effectiveness. In this study, a novel miR‐133a zipper nanoparticle (NP) system that integrates miRNA zipper technology with rolling circle transcription (RCT) to achieve targeted delivery and specific regulation of miR‐133a in adipocytes, is presented. This innovative approach can greatly enhance the delivery and release of miR‐133a zippers, increasing the expression of thermogenic genes and mitochondrial biogenesis. he miR‐133a zipper NP is utilized for the delivery of miRNA zipper‐blocking miR‐133a, an endogenous inhibitor of Prdm16 expression, to enhance the thermogenic activity of adipocytes by modulating their transcriptional program. Inhibition of miR‐133a through the miR‐133a zipper NP leads to more significant upregulation of thermogenic gene expression (Prdm16 and Ucp1) than with the free miR‐133a zipper strand. Furthermore, miR‐133a zipper NPs increase the number of mitochondria and induce heat production, reducing the size of 3D adipose spheroids. In short, this study emphasizes the role of RNA NPs in improving RNAi stability and specificity and paves the way for broader applications in gene therapy. Moreover, this research represents a significant advancement in RNAi‐based treatments, pointing toward a promising direction for future therapeutic strategies.
Targeted Macrophage Re‐Programming: Synergistic Therapy With Methotrexate and RELA siRNA Folate‐Liposome in RAW264.7 Cells and Arthritic Rats
Authors: Nasra Simran , Bhatia Dhiraj , Kumar Ashutosh 
Published: May 2024

AbstractRheumatoid arthritis (RA) is a chronic autoimmune disorder characterized by joint inflammation and destruction. Current treatments, such as Methotrexate (MTX), though effective, often face limitations such as high plasma Cmax and lack of sustained release. This study explores a synergistic approach to RA therapy using folate‐liposomal co‐delivery of MTX and RELA siRNA (short interfering RNA), targeting RAW264.7 macrophage repolarization via nuclear factor kappa B (NF‐κB) pathway inhibition. Extensive in vitro characterizations demonstrate the stability and biocompatibility of this therapy via folate‐liposomes. In the collagen‐induced arthritis (CIA) rat model, treatment leads to reduced synovial inflammation and improved mobility. The combined MTX and RELA siRNA approach indirectly inhibits inflammatory cytokines, rheumatoid factor (RF), and C‐reactive protein (CRP). Targeted macrophage delivery shows marked therapeutic effects in RAW264.7 murine macrophages, potentially modulating M1 to M2 polarization. This research presents a promising avenue for innovative RA therapies by inhibiting the inflammatory cascade and preventing joint damage.
Targeted Clearance of Senescent Cells Via Engineered Extracellular Vesicles Reprograms Tumor Immunosuppressive Microenvironment
Authors: Ji Panpan , Wang Chen , Liu Yang , Guo Xin , Liang Yuan , Wei Jiangpeng , Liu Zhaoyou , Gong Li , Yang Guodong , Ji Gang 
Published: May 2024

AbstractUnravelling the mechanisms for the immunosuppressive tumor microenvironment and developing corresponding therapeutic strategies are of great importance to improve the cancer immunotherapy. This study has revealed that there are abundant senescent cells accumulated in the colon cancer tissue, which contributes greatly to the immunosuppressive microenvironment. Oral delivery of Dasatinib and Quercetin (D+Q) eliminates the senescent cells with compromised efficiency due to the poor tumor penetration and short half‐life. To improve the efficacy of senescent cell clearance, this work has developed an extracellular vesicle (EV) based senolytic strategy. The engineered senolytic EVs have anti‐GPNMB (a senescent cell surface marker) displayed on the surface and D+Q loaded on the membrane. In a syngeneic mouse model, senolytic EVs efficiently and selectively eradicate the senescent cells and in turn unleashes the antitumor immunity. With the antitumor immunity boosted, cancer growth is inhibited and the survival is prolonged. In summary, this work has illuminated that senescent cells contribute to the immunosuppressive microenvironment in colon cancer and proposes a novel strategy to conquer the problem by EV‐based senolytics.
Hydrogel Coatings of Implants for Pathological Bone Repair
Authors: Li Mengqing , Fan Youzhun , Ran Maofei , Chen Haoyan , Han Jien , Zhai Jinxia , Wang Zhengao , Ning Chengyun , Shi Zhifeng , Yu Peng 
Published: May 2024

AbstractHydrogels are well‐suited for biomedical applications due to their numerous advantages, such as excellent bioactivity, versatile physical and chemical properties, and effective drug delivery capabilities. Recently, hydrogel coatings have developed to functionalize bone implants which are biologically inert and cannot withstand the complex bone tissue repair microenvironment. These coatings have shown promise in addressing unique and pressing medical needs. This review begins with the major functionalized performance and interfacial bonding strategy of hydrogel coatings, with a focus on the novel external field response properties of the hydrogel. Recent advances in the fabrication strategies of hydrogel coatings and their use in the treatment of pathologic bone regeneration are highlighted. Finally, challenges and emerging trends in the evolution and application of physiological environment‐responsive and external electric field‐responsive hydrogel coatings for bone implants are discussed.
Enhanced Oxygen Evolution and Zinc‐Air Battery Performance via Electronic Spin Modulation in Heterostructured Catalysts
Authors: Yang Linlin , He Ren , Botifoll Marc , Zhang Yongcai , Ding Yang , Di Chong , He Chuansheng , Xu Ying , Balcells Lluís , Arbiol Jordi , Zhou Yingtang , Cabot Andreu 
Published: May 2024

AbstractBeyond optimizing electronic energy levels, the modulation of the electronic spin configuration is an effective strategy, often overlooked, to boost activity and selectivity in a range of catalytic reactions, including the oxygen evolution reaction (OER). This electronic spin modulation is frequently accomplished using external magnetic fields, which makes it impractical for real applications. Herein, spin modulation is achieved by engineering Ni/MnFe2O4 heterojunctions, whose surface is reconstructed into NiOOH/MnFeOOH during the OER. NiOOH/MnFeOOH shows a high spin state of Ni, which regulates the OH− and O2 adsorption energy and enables spin alignment of oxygen intermediates. As a result, NiOOH/MnFeOOH electrocatalysts provide excellent OER performance with an overpotential of 261 mV at 10 mA cm−2. Besides, rechargeable zinc‐air batteries based on Ni/MnFe2O4 show a high open circuit potential of 1.56 V and excellent stability for more than 1000 cycles. This outstanding performance is rationalized using density functional theory calculations, which show that the optimal spin state of both Ni active sites and oxygen intermediates facilitates spin‐selected charge transport, optimizes the reaction kinetics, and decreases the energy barrier to the evolution of oxygen. This study provides valuable insight into spin polarization modulation by heterojunctions enabling the design of next‐generation OER catalysts with boosted performance.
Anisotropic 2D van der Waals Magnets Hosting 1D Spin Chains
Authors: Park Eugene , Philbin John P. , Chi Hang , Sanchez Joshua J. , Occhialini Connor , Varnavides Georgios , Curtis Jonathan B. , Song Zhigang , Klein Julian , Thomsen Joachim D. , Han Myung‐Geun , Foucher Alexandre C. , Mosina Kseniia , Kumawat Deepika , Gonzalez‐Yepez N. , Zhu Yimei , Sofer Zdeněk , Comin Riccardo , Moodera Jagadeesh S. , Narang Prineha , Ross Frances M. 
Published: May 2024

AbstractThe exploration of 1D magnetism, frequently portrayed as spin chains, constitutes an actively pursued research field that illuminates fundamental principles in many‐body problems and applications in magnonics and spintronics. The inherent reduction in dimensionality often leads to robust spin fluctuations, impacting magnetic ordering and resulting in novel magnetic phenomena. Here, structural, magnetic, and optical properties of highly anisotropic 2D van der Waals antiferromagnets that uniquely host spin chains are explored. First‐principle calculations reveal that the weakest interaction is interchain, leading to essentially 1D magnetic behavior in each layer. With the additional degree of freedom arising from its anisotropic structure, the structure is engineered by alloying, varying the 1D spin chain lengths using electron beam irradiation, or twisting for localized patterning, and spin textures are calculated, predicting robust stability of the antiferromagnetic ordering. Comparing with other spin chain magnets, these materials are anticipated to bring fresh perspectives on harvesting low‐dimensional magnetism.
Toward Circular Energy: Exploring Direct Regeneration for Lithium‐Ion Battery Sustainability
Authors: Wu Xiaoxue , Liu Yuhang , Wang Junxiong , Tan Yihong , Liang Zheng , Zhou Guangmin 
Published: May 2024

AbstractLithium‐ion batteries (LIBs) are rapidly developing into attractive energy storage technologies. As LIBs gradually enter retirement, their sustainability is starting to come into focus. The utilization of recycled spent LIBs as raw materials for battery manufacturing is imperative for resource and environmental sustainability. The sustainability of spent LIBs depends on the recycling process, whereby the cycling of battery materials must be maximized while minimizing waste emissions and energy consumption. Although LIB recycling technologies (hydrometallurgy and pyrometallurgy) have been commercialized on a large scale, they have unavoidable limitations. They are incompatible with circular economy principles because they require toxic chemicals, emit hazardous substances, and consume large amounts of energy. The direct regeneration of degraded electrode materials from spent LIBs is a viable alternative to traditional recycling technologies and is a nondestructive repair technology. Furthermore, direct regeneration offers advantages such as maximization of the value of recycled electrode materials, use of sustainable, nontoxic reagents, high potential profitability, and significant application potential. Therefore, this review aims to investigate the state‐of‐the‐art direct LIB regeneration technologies that can be extended to large‐scale applications.
Experimental Evidence of the Molecular and Macroscopic Origins of Circular Dichroism in Chiral Metal‐Halide Networks
Authors: Abhervé Alexandre 
Published: May 2024

AbstractClockwise or counter‐clockwise spin coating? In the current hot research topic of chiral metal‐halide semiconductors, several investigations have been undertaken in order to reveal their natural optical activity and have reported dissymmetry factors (gabs) for thin films of many hybrid compounds, usually without considering the macroscopic anisotropies inherent to solid‐state samples. Yet, CD in the solid state can be strongly modulated by the co‐existence of linear dichroism (LD) and linear birefringence (LB). Theoretical studies recently revealed the importance of such macroscopic interferences in the CD response of solid‐state samples, often referred as symmetric (sLDLB) and antisymmetric (aLDLB) effects. Based on the newly synthesized one‐dimensional lead‐halide networks of formula (S/R‐HP1A)PbBr3 and (S/R‐HP1A)PbI3, an experimental method to accurately discriminate between CD, sLDLB and aLDLB in chiral metal‐halide networks is here presented. The main experimental conditions influencing sLDLB and aLDLB amplitude are also highlighted, such as the concentration of the precursor solution and the spin‐coating rotation direction, finally providing a complete experimental guide for the forthcoming chiroptical investigations of such important family of chiral hybrid materials.
A Real‐Time Display Screen Based on Organohydrogel with Tunable Fluorescence
Authors: Jia Hong , Chen Zihao , Chen Yiping , Wang Xilin , Wei Jie 
Published: May 2024

AbstractIn this study, a multi‐monomer organohydrogel network is fabricated based on radical polymerization. Acrylic acid (AA) and dimethylaminoethyl methacrylate (DMAEMA) are used as hydrophilic monomers, and methoxyethyl acrylate (MEA) serves as a hydrophobic monomer. To endow the organohydrogel with a photo‐responsive property, a fluorescent monomer, 1′‐acryloyl chloride‐3′,3′‐dimethyl‐6‐nitrospiropyran (SPMA) is added. Under ultraviolet (UV) and visible light irradiation, SPMA undergoes ring‐opening and ring‐closing isomerization reactions, respectively. This leads to enhanced and reduced fluorescence. This fluorescence tunability allows for the local regulation of fluorescence in the organohydrogel using a photomask. By employing UV and visible light, complex information can be repeatedly written and erased on the organohydrogel. Additionally, based on the interactions between dimethyl sulfoxide (DMSO) and water within the system, the organohydrogel exhibits excellent anti‐freezing and water‐holding properties, allowing its use in low‐temperature environments and extended preservation time. The organohydrogel has precise information writing capabilities and is more difficult to falsify as an information encryption platform. This study provides guidance for future researchers to develop information writing capabilities with higher precision and broader applications in various environments using smart materials.
Realization of Narrow‐Bandwidth Cu‐Ga‐S‐Based Quantum Dots with Controllable Luminescence
Authors: Niu Wentao , Xie Xiulin , Chen Zhong , Sun Ruixin , Li Yu , Wang Shuaibing , Zhang Yu , Yang Chunhe , Tang Aiwei 
Published: May 2024

AbstractRecently, I‐III‐VI type quantum dots (QDs) have attracted considerable attention in display technology due to their large‐scale tunable emission and environmentally friendly characteristics. However, within this family, narrow‐bandwidth Cu‐based QDs have rarely been reported. Herein, the synthesis of narrow‐bandwidth blue‐emitting Cu‐Ga‐S (CGS)‐based QDs is reported by a hot‐injection method for the first time, boasting a narrow full width at half‐maximum (FWHM) of 29 nm, closely approaching that of traditional Cd‐based QDs. Through precisely controlling the temperature of nucleation stage, CGS‐based QDs showcase a representative blue emission at 475 nm, featuring the narrowest FWHM and a photoluminescence quantum yield (PLQY) of 32%. Besides, the femtosecond transient fluorescence (fs‐TA) characterization indicates that the narrow‐bandwidth luminescence is attributed to band‐to‐hole recombination rather than donor‐acceptor pair (DAP) recombination. The work opens a new avenue for narrow‐bandwidth I‐III‐VI QDs, offering increased potential for applications in blue‐light‐emitting devices.