bluuebunny/crossref_metadata_2025_split huggingface dataset:
Investigating the interplay of genetic variations, MCP-1 polymorphism, and docking with phytochemical inhibitors for combatting dengue virus pathogenicity through in silico analysis
Authors: Bibi Maryam , Waseem Muhammad , Hussain Nageen , Aziz Tariq , Alasmari Abdullah F. 
Published: April 2024

Abstract
Understanding ten significant of dengue virus a paramount due to its persistent threat across the globe causing numerous epidemic and millions of deaths every year. Despite advancement in healthcare, emerging outbreaks continue to claim millions of lives annually. The virus with its various serotype possesses a significant challenge to public health worldwide, its transmission through the arthropods which feed on the blood of higher animals further exacerbates its impact. This elucidating the mechanism and factor contributing to dengue virus pathogenicity is essential for developing strategies to combat its spreading. A systemic review is done while studying about Dengue virus serotypes to evaluate the relationship of dengue with other viral load and to develop an inhibitor in viral protein by using different bioinformatics tools in silico molecular docking. Phytochemicals were chosen to hit the target site of protein for inhibiting its active site in pathogenesis of Dengue virus. A phylogenetic lineage was observed of virus with other members of its family. Dengue virus has same similarities in some part of genomic structure with other viruses. Data bases were used to trace the genome of the virus. Different components of virus were analyzed and link was developed among those components within virus and other family members. Protein docking was performed by using the bioinformatics software auto docking. A pharmaceutical drug designing was developed to create inhibitor of protein structure in Dengue virus serotype-2. A comprehensive review of the methodology employed in our study including the experimental and computational techniques were utilized. Further we presented the results by analysis of genetic variation MCP-1 polymorphism and docking phytochemical inhibitors.
Mechanical and micro-structural studies of pulsed and constant current TIG weldments of super duplex stainless steels and Austenitic stainless steels
Authors: Yelamasetti Balram , Karuna B. N. R. , Vishnu Vardhan T. , Dasore Abhishek , Saxena Kuldeep K. , Faroque Firoz Alam , Revathi V. , Abduvalieva Dilsora 
Published: April 2024

Abstract
In the present research work, the influence of heat input rates on microstructures, hot tensile properties, and weld surface hardness number of Super Duplex Stainless Steel 2507 super duplex steels and austenitic steels 316L plates were investigated. Pulsed current and constant current modes were used in Tungsten Inert Gas (TIG) welding to join the dissimilar metals using ER2205 as filler. Microstructural studies were revealed at different zones of pulsed and constant current TIG weldments using optical microscopy. The tensile test was conducted at two different temperature conditions (i.e., 27 and 350°C) to investigate the strength of dissimilar weldments. Hardness measurements were made on the weld surface along the transverse direction using Vicker’s hardness tester. The microstructures revealed the formation of inter-granular austenite at the fusion zone with grain boundaries with austenite structures. Due to the constant heat input, a significant microstructural development with high austenite fractions was observed in constant current (CC)-TIG weldment. In comparison to CC-TIG weldments (UTS at 27°C = 600 MPa UTS at 350°C = 456 MPa), higher tensile characteristics were noted in Pulsed Current (PC)-TIG weldments (UTS at 27°C = 695 MPa UTS at 350°C = 475 MPa). The UTS of PC-TIG weldment is improved by 15.8% when compared to CC-TIG weldment due to the controlled heat input rates. PC-TIG weldments exhibited improved hardness numbers in various zones with smaller HAZ widths than CC-TIG weldments.
Method of feature extraction of abnormal communication signal in network based on nonlinear technology
Authors: Gong Baofu 
Published: April 2024

Abstract
Accurate extraction of abnormal communication signal features in the network is the basis to ensure the completion of network communication. Therefore, a method of feature extraction of abnormal communication signal in network based on nonlinear technology is proposed. In this method, wavelet transform is adopted to decompose the abnormal network communication signals in the high- and low-frequency bands. According to the distribution characteristics of noise and signal in the frequency band, the corresponding parameters are selected for phase space reconstruction and nonlinear dimension reduction of local tangent space mainstream shape recognition algorithm, and the decomposition coefficients of wavelet packet after noise reduction are reconstructed to realize the nonlinear noise reduction of abnormal signal; the denoised abnormal communication signal in network is mapped to the high-dimensional feature space. The principal component is analyzed in accordance with the nonlinear function in the mapped feature space, and the nonlinear function is solved by self-organizing neural network to output the principal component extraction result. According to test results, this method has a significant signal noise reduction effect, results are more than 92% for different abnormal communication signals, and the features of abnormal signals are accurately extracted.
Unraveling PCOS: Exploring its causes and diagnostic challenges
Authors: Dar Mohd Altaf , Maqbool Mudasir , Qadrie Zulfkar , Ara Irfat , Qadir Afshana 
Published: April 2024

Abstract
Women in the reproductive age range are usually affected with Polycystic Ovary Syndrome (PCOS), a complex and multifaceted condition. Anovulation, hyperandrogenism, and metabolic difficulties like hyperglycemia, hypertension, and obesity in women are all manifestations of this condition, which also affects the reproductive system. The National Institutes of Health in the 1990s, Rotterdam in 2003, and Androgen Excess Polycystic Ovary Syndrome in 2009 all contributed to the evolution of the diagnostic criteria for PCOS. The 2003 Rotterdam criteria are currently the most generally used criteria. They call for at least two of the three criteria – irregular menstrual periods, polycystic ovary morphology on imaging, and hyperandrogenism – either clinically or biochemically – to be present in order to diagnose PCOS. It is currently being suggested that the anti-Müllerian hormone in serum be used instead of follicular count as an official indicator of polycystic ovarian morphology/PCOS. Hyperandrogenism and irregular periods are essential components in determining PCOS in adolescent patients. More recently, it has been shown that artificial intelligence, especially machine learning, holds great promise for detecting and predicting PCOS with high accuracy, potentially assisting in early management and treatment decisions. Examining the underlying mechanisms, clinical symptoms, and challenges involved in making a diagnosis of PCOS in females is the premise of this review article.
Correcting misinterpretations on the distribution of feasible solution lengths in the traveling salesman problem
Authors: Shaw Jerry L. , Fuqua Donovan , Sohn Hansuk , Rodriguez-Borbon Manuel Ivan , Pimentel Victor 
Published: April 2024

The traveling salesman problem (TSP) is the canonical combinatorial optimization problem famous throughout literature. There exists an objective function associated with every feasible solution. However, the increase in the number of possible solutions makes this an NP-Hard problem. We show that the central limit theorem (CLT) applies to the problem. We then conduct extensive computational testing to show that the cycle lengths tend to a normal distribution as the problem grows large. When the size of the TSP problem exceeds computational power, better understanding solution distributions allows us to save resources. This is a non-trivial result as understanding solution distributions in huge TSP problems helps us to minimize computational effort that may not lead to significantly better results.
William Metcalf, <i>Utopian Dreams and Dystopian Nightmares</i>
Authors: Kitson Michael 
Published: April 2024

William Metcalf, Utopian Dreams and Dystopian NightmaresBrisbane: Boolarong Press, 2022, 196 pp., A$34.99, ISBN: 9 7819 2264 3445
Childhood: The Paradoxes of Autonomy
Authors: Polivanova Katerina N. , Bochaver Alexandra A. 
Published: April 2024

The article problematizes the possibility of developing agency in childhood. It is shown that the usually non-differentiable constructs "agency" and "autonomy" psychologically represent fundamentally different actions. The basis for their distinction is the nature of the individual's interaction with the social structure. Autonomy is an integration into an existing structure, the acquisition of skills for independent functioning in it. Agency, on the other hand, involves the transformation of the structure and "crossing the border of semantic fields," according to Yu.M. Lotman.
There have been several important "turns" in childhood research over the past decades. Initially, childhood was considered as a preparation for adulthood, which was implemented in fundamentally hierarchical forms of education. Since about the 1970s, children have been talked about as potential actors in the social world. And since the beginning of the XXI century, the discussion of independence (autonomy) has been gaining momentum, as part of which they distinguish the ability to act independently of others and act in accordance with their goals and beliefs.
The authors distinguish agency as overcoming the boundaries characterizing the structure, and autonomy as actions within the initially defined boundaries. They consider productive action (event) to be the mechanism of agency as a situation—changing action, and as a way of "learning" agency - a trial, including a game.
Examples of statements by teenagers and young people that can be qualified as specific to agency, independence and volitional action are given.
Entrepreneurial Education of Russian Universities' Students as a Way to Form Agency
Authors: Morozova Ekaterina V. 
Published: April 2024

The number and variety of entrepreneurship training programs in universities is growing around the world. At the same time, there is no consensus in the research field on what the future entrepreneur should be taught and how to measure the effectiveness of such training. One of the points of view suggests that the result of teaching entrepreneurship at a university should be the formation students' "agency" - the ability to purposefully change the environment through their own entrepreneurial project. However, at this stage, there is no agreement in the scientific and educational community on what indicators can be included in the corresponding construct, so that a reasonable conclusion can be drawn whether agency is formed in the process of entrepreneurial learning. This article attempts to answer this question by conducting interviews with graduates of the leading entrepreneurship education programs that have been implemented both in Russian universities (formal sector, 64 interviews)) and in the informal sector of student education (24 interviews). In this study, students' internal attitudes related to understanding the essence of entrepreneurial activity were studied, and these attitudes were compared with the theoretical construct of agency in its interpretation, presented in a series of earlier works by HSE staff (Sorokin P.S. et al.). In the empirical part of the study, it was confirmed that the internal attitudes of students who have completed entrepreneurial training and successfully implemented their entrepreneurial project do indeed correspond to the theoretical framework of agency. The main contribution of this article is the development of agency indicators in relation to entrepreneurial learning and the justification of their applicability for assessing the results of educational programs.
From the Phenomenon of Self-Sufficiency to the Mechanisms of Self-Determination
Authors: Leontiev Dmitry A. 
Published: April 2024

The paper presents a systematic analysis of key explanatory concepts of different levels of abstraction, being used in the psychological and interdisciplinary concepts for the explanation of the phenomenon of self-sufficiency. The phenomenon of self-sufficiency is defined basing on the understanding of person as the instance which human being as an autonomous agent may oppose to both internal impulses and external pressures, biological and social determinants acting both from within and from outside. The closest construct is that of agency. Agency is viewed as personality variable, reflecting the person’s capacity to initiate and control their actions. Agency appears as the explanatory construct as regards the observable phenomenon of self-sufficiency. However, being holistic and indivisible, it, in its turn, needs a more detailed analysis.
Such a brief analysis is provided for the psychological constructs of proactivity, autonomy, personal causation and self-determination as well as for more specific theoretical models of intrinsic / extrinsic motivation, phases of a motivated action, personality potential as the potential of autoregulation, and freedom and responsibility as two sides of personal causation and autodetermination, taking shape during the transition from childhood to adulthood. Freedom is treated as the highest form of activity, a side of personal causation and autodetermination which allows us feeling independent of outer pressures and inner impulses. Responsibility is the second side of personal causation and autodetermination, the highest form of autoregulation, associated with viewing oneself as a cause of some events in the world, it is a controlled capacity of producing goal-directed changes in oneself and in the world. In conclusion the construct of personal life position as an integral person’s attitude to one’s own life is introduced. The constructs analyzed in the paper present the multilevel conceptual frame for treating the phenomenon of self-sufficiency.
The Effect of 100% Watermelon (Citrullus lanatus) Extract on Tooth Discoloration with Rub Techniques
Authors: Setyawati Any , Saraswati Dea Rachnadewi 
Published: April 2024

Tooth color can change because of several factors that are needed for teeth whitening. Teeth whitening can be performed on vital and non-vital teeth. Home bleaching is a vital whitening treatment that many people choose because practice can be done at home. Bleaching agent used for home bleaching techniques is 10% -22% carbamide peroxide. However, carbamide peroxide has side effects on the oral cavity. So, several previous researches have examined natural ingredients that contain the ability to whiten teeth. One of them is 100% watermelon extract which is proven to whitenteeth by immersing. However, this method cannot be applied clinically, so the purpose of this research is to know the effect of watermelon extract on tooth discoloration with rub techniques application. This type of research is an experimental laboratory. 10 maxillary premolars were discolored which were divided into two groups (watermelon extract and 10% carbamide peroxide). Each group was given the treatment 3 hours per-day for 14 days. After the bleaching process, the teeth are cleaned and immersed in a solution of saliva. Before and after bleaching, they were measured with a shade guide and spectrophotometer. Data analysis used paired t-test and wilcoxon. The results of paired t-test on group 1 p=0.024 (p <0.05). The wilcoxon test results on group 2 with p=0.043 (p <0.05). Both have influence, but the application of 10% watermelon extract is lower than 10% carbamide peroxide. It can be concluded: 100% watermelon extract with rubbing techniques has an effect on teeth whitening. Although, lower than 10% carbamide peroxide
PERSPECTIVAS SOCIOLINGUÍSTICAS NO MATERIAL DIDÁTICO APOSTILADO: UMA ANÁLISE ANTES DA BNCC
Authors: Costa Katiana Possamai , Di Palma Back Angela Cristina 
Published: April 2024

A importância do livro didático não é de hoje, sua existência data ainda no século XIX. Com o tempo, esse livro obteve diferentes finalidades que Lajolo e Zilberman (2019) retomam e apontam como a cartilha para alfabetização; seleta para aprendizagem literária; manual para as ciências ou profissionalização. Hoje, comumente chamados de livro didático ou apostila. Neste artigo, trabalhamos com um material apostilado de Língua Portuguesa, adotado para o Ensino Médio de um colégio da rede particular de ensino do município de Criciúma (SC), com o objetivo de analisar como a sociolinguística se apresenta antes da reformulação desse material para cumprir com os pressupostos da Base Nacional Comum Curricular (BNCC). Esta pesquisa, de cunho documental, pautou-se em autores como Bortoni-Ricardo (2005), Faraco (2004; 2008) e, principalmente, Bagno (2007; 2013), pois definimos como categoria de análise o que o autor chama de “o jogo dos sete erros”. A discussão dos dados se dá de forma qualitativa, de modo a concluir que, embora o material apresente alguns equívocos, encaminha-se, aos poucos, para uma pedagogia da variação linguística.

Palavras-chave: Variação linguística. Material didático. Sociolinguística.
Suicide Ideation and the Association of Chronic Disease among American Indians
Authors: Hodge Felicia Schanche , Roca Rey Paolo Ernesto , Samuel-Nakamura Christine , Robbins Wendie , Warda Umme Shefa 
Published: April 2024

Objective
To explore associations of chronic disease, perceived wellness, adverse experiences, and suicide ideation among American Indians.

Methods
Thirteen California health clinic registries formed the random household survey sampling frame (N=459) during the first stage of an intervention trial on wellness. Measures included sociodemographics, wellness status, health conditions, suicide ideation, cultural connectivity (speaking tribal language, participating in cultural practices, and feeling connected to the community), and history of physical, sexual, verbal abuse and neglect in childhood, adolescence, and adulthood. Chi square and Fisher exact tests examined bivariate, unadjusted relationships, while multiple logistic regression analysis examined adjusted associations.

Results
Adverse experiences, specifically physical abuse and sexual abuse, were associated with obesity in childhood. Having poor cultural connectivity was significantly associated with (1) low perceptions of wellness; (2) physical abuse in childhood and adolescence; (3) sexual abuse in childhood, adolescence, and adulthood; and (4) verbal abuse and neglect in adulthood. Poor perception of wellness was also correlated with suicide ideation.

Conclusions
The relationships between suicide ideation, chronic disease, connectivity, and perception of wellness among American Indians are explored in this article.
Technologic and Nontechnologic Barriers to Implementing Behavioral Health Homes in Community Mental Health Settings During the COVID-19 Pandemic
Authors: Woltmann Emily M. , Osorio Brianna , Yuan Christina T. , Daumit Gail L. , Kilbourne Amy M. 
Published: April 2024

Background
Persons with serious mental illnesses (SMIs) experience disparities in health care and are more likely to die from physical health conditions than the general population. Behavioral health homes are used in public sector mental health programs to deploy collaborative care to improve physical health for those with SMIs. During the COVID-19 pandemic, these programs faced new challenges in delivering care to this vulnerable group.

Purpose
To describe barriers to implementing or sustaining behavioral health homes, experienced by community mental health workers during the COVID-19 pandemic, and the strategies used to address these challenges.

Methods
In-depth qualitative interviews were conducted among the behavioral health workforce in Maryland and Michigan community mental health programs. Interview questions were derived from the Consolidated Framework for Implementation Research (CFIR), and responses related to implementing and sustaining health homes during the pandemic were coded and themes were analyzed by using an inductive approach.

Results
Overall, 72 staff members across 21 sites in Maryland and Michigan were interviewed. Implementation barriers/strategies identified occurred across multiple CFIR domains (client, mental health system, physical health system). Interviewees discussed technologic and nontechnologic challenges as well as strategies to address technology issues. Strategies were more frequently discussed by providers when the barrier was viewed at the client level (eg, low technology literacy) versus the broader system (eg, canceled primary care visits).

Conclusions
Community mental health staff described barriers beyond technology in caring for individuals with SMIs and physical health conditions. Further research should examine how implementation strategies address both technologic and nontechnologic barriers to collaborative care.
TINDAK TUTUR ILOKUSI DALAM REPRESENTASI HUMOR PADA ACARA TELEVISI LAPOR PAK!
Authors: Saputro Eko Wahyu , Sumarwati Sumarwati , Ulya Chafit , Sohnui Suhailee 
Published: April 2024

<span class="s11">Humor memiliki manfaat penting dalam berkomunikasi, misalnya </span><span class="s6">meredakan ketegangan dan membuat orang lain menjadi lebih rileks</span><span class="s6"> serta memberi hiburan</span><span class="s6">.</span><span class="s6"> </span><span class="s11">Bertutur yang merepresentasikan humor bermuatan humor tidak dimiliki setiap orang, namun kompetensi tersebut dapat dipelajari dari tuturan para pelaku humor, termasuk </span><span class="s11">dalam acara</span><span class="s11"> humor di televisi. Penelitian ini bertujuan untuk mengidemtifikasi bentuk dan fungsi tindak tutur ilokusi pada acara televise </span><span class="s15">Lapor Pak!</span><span class="s11"> Pendekatan penelitiannya adalah analaisis pragmatik dengan metode kualitatif deskriptif. Yang menjadi sumber data adalah video acara humor </span><span class="s15">Lapor Pak! </span><span class="s11">yang</span><span class="s11"> diperolah dari Youtube</span><span class="s15">.</span><span class="s11"> Teknik pengambilan sampel menggunakan </span><span class="s15">purposive </span><span class="s11">sampling. Untuk mengumpulkan data dilakukan analisis dokumen. Teknik uji validitas yang diterapkan adalah triangulasi teori. Hasil penelitian menunjukkan ada lima bentuk tindak tutur ilokusi pada acara humor </span><span class="s15">Lapor Pak!</span><span class="s11"> </span><span class="s11">yaitu</span><span class="s11"> tindak tutur asertif, tindak tutur direktif, tindak tutur ilokusi ekspresif, tindak tutur ilokusi komisif dan tindak tutur ilokusi deklaratif. </span><span class="s11">Fungsi tindak tutur bermuatan humor antara lain fungsi memohon, meminta, mengajak, menekan, mendoa, bertanya, menginterogasi, memerintah, menginstruksikan, melarang, membatasi, membolehkan, memberi wewenang, memberi izin, menasihatkan, memperingatkan, dan menyarankan. </span><span class="s6">Bentuk tindak tutur ilokusi yang dominan adalah tindak tutur ilokusi direktif, sedangkan fungsi tindak tutur yang paling dominan adalah fungsi memerintah. Hal itu relevan dengan konteks judul acara Lapor Pak yaitu ber-setting di kantor polisi yang menerima laporan kasus-kasus dan memberi perintah untuk mengatasinya.</span>