bluuebunny/crossref_metadata_2025_split huggingface dataset:
Conformational and Substitution Effects on the Donor and Reducing Strength of Tin(II) Porphyrinogens
Authors: Ruppert Heiko , Meister Arne , Janßen Paul , Greb Lutz 
Published: May 2024

AbstractMeso‐octaalkylcalix[4]pyrrolates are a class of redox‐active porphyrinogen ligands. They have been well established in d‐ and f‐block chemistry for over three decades but have only recently been introduced as ligands for p‐block elements. Here, we present a study on the influence of meso‐substituents on the redox chemistry of calix[4]pyrrolato stannate(II) dianions [2R]2− (R=Me, Et). Expansion of the normal‐mode structural decomposition (NSD) method, well known for porphyrin chemistry, provides insights into the ligand conformation of a calix[4]pyrrolato p‐block complex. Combined with the results of spectroscopic donor scaling, electrochemical studies, and quantum mechanical bond analysis tools, subtle but significant substitution and conformational effects on the electronic structure are revealed. Exploiting this knowledge rationalizes the role of this class of tin(II) dianions to act as potent reducing agents, but can also be expanded for other central elements. Photoexcitation boosts this reactivity further, allowing for the reduction of even challenging chlorobenzene.
Research on multi‐mechanism synergistic effects of gas cross‐scale percolation in tight gas reservoirs of Yanchang oilfield
Authors: Gao Lijun , Bai Ning , Qiao Linsheng , Ji Wei , Miao Tao 
Published: May 2024

AbstractRevealing the gas transport patterns at the microscale and nanoscale is of great scientific and engineering significance for unconventional oil and gas exploration and development. This paper first systematically analyzes the properties of gas transport mechanism under different Knudsen number conditions. Second, the coupling modes of the cross‐scale multi‐drive mechanism are systematically categorized, and three typical coupling calculation methods are pointed out. Again, the rationality of the cross‐scale multi‐agency coupling is quantitatively calculated. The results show that (a) Under the influence of Fick's diffusion equation, when Knr > 0, the coupled ‘slip flow–Fick diffusion–Knudsen diffusion’ equation does not converge to the Knudson diffusion equation. (b) The ‘Fick diffusion–Knudsen diffusion’ coupled equation is calculated to be more than 102 times as large as the Knudsen diffusion equation.
Relevance of individual bronchial symptoms for asthma diagnosis and control in patients with rhinitis: A MASK‐air study
Authors: Sousa‐Pinto Bernardo , Louis Gilles , Vieira Rafael J. , Czarlewski Wienczyslawa , Anto Josep M. , Amaral Rita , Sá‐Sousa Ana , Brussino Luisa , Canonica G. Walter , Loureiro Claudia Chaves , Cruz Alvaro A. , Gemicioglu Bilun , Haahtela Tari , Kupczyk Maciej , Kvedariene Violeta , Larenas‐Linnemann Desirée E. , Pham‐Thi Nhân , Puggioni Francesca , Regateiro Frederico S. , Romantowski Jan , Sastre Joaquin , Scichilone Nicola , Taborda‐Barata Luis , Ventura Maria Teresa , Agache Ioana , Bedbrook Anna , Benfante Alida , Bergmann Karl C. , Bosnic‐Anticevich Sinthia , Bonini Matteo , Boulet Louis‐Philippe , Brusselle Guy , Buhl Roland , Cecchi Lorenzo , Charpin Denis , Costa Elisio M. , Del Giacco Stefano , Jutel Marek , Klimek Ludger , Kuna Piotr , Laune Daniel , Makela Mika , Morais‐Almeida Mario , Nadif Rachel , Niedoszytko Marek , Papadopoulos Nikolaos G. , Papi Alberto , Pfaar Oliver , Rivero‐Yeverino Daniela , Roche Nicolas , Samolinski Boleslaw , Shamji Mohamed H. , Sheikh Aziz , Ulrik Charlotte Suppli , Usmani Omar S. , Valiulis Arunas , Yorgancioglu Arzu , Zuberbier Torsten , Fonseca Joao A. , Pétré Benoit , Louis Renaud , Bousquet Jean ,   MASK‐air think tank
Published: May 2024

AbstractRationaleIt is unclear how each individual asthma symptom is associated with asthma diagnosis or control.ObjectivesTo assess the performance of individual asthma symptoms in the identification of patients with asthma and their association with asthma control.MethodsIn this cross‐sectional study, we assessed real‐world data using the MASK‐air® app. We compared the frequency of occurrence of five asthma symptoms (dyspnea, wheezing, chest tightness, fatigue and night symptoms, as assessed by the Control of Allergic Rhinitis and Asthma Test [CARAT] questionnaire) in patients with probable, possible or no current asthma. We calculated the sensitivity, specificity and predictive values of each symptom, and assessed the association between each symptom and asthma control (measured using the e‐DASTHMA score). Results were validated in a sample of patients with a physician‐established diagnosis of asthma.Measurement and Main ResultsWe included 951 patients (2153 CARAT assessments), with 468 having probable asthma, 166 possible asthma and 317 no evidence of asthma. Wheezing displayed the highest specificity (90.5%) and positive predictive value (90.8%). In patients with probable asthma, dyspnea and chest tightness were more strongly associated with asthma control than other symptoms. Dyspnea was the symptom with the highest sensitivity (76.1%) and the one consistently associated with the control of asthma as assessed by e‐DASTHMA. Consistent results were observed when assessing patients with a physician‐made diagnosis of asthma.ConclusionsWheezing and chest tightness were the asthma symptoms with the highest specificity for asthma diagnosis, while dyspnea displayed the highest sensitivity and strongest association with asthma control.
Results of ponatinib as frontline therapy for chronic myeloid leukemia in chronic phase
Authors: Haddad Fadi G. , Sasaki Koji , Nasr Lewis , Short Nicholas J. , Kadia Tapan , Dellasala Sara , Cortes Jorge , Nicolini Franck E. , Issa Ghayas C. , Jabbour Elias , Kantarjian Hagop 
Published: May 2024

ABSTRACTBackgroundPonatinib is a third‐generation BCR::ABL1 tyrosine kinase inhibitor (TKI) with robust activity in Philadelphia chromosome–positive leukemias. Herein, we report the long‐term follow‐up of the phase 2 trial of ponatinib in chronic myeloid leukemia in chronic phase.MethodsPatients received ponatinib 30 to 45 mg/day. The primary end point was the rate of 6‐month complete cytogenetic response (CCyR). The study was held in June 2014 because of the risk of cardiovascular toxicity, requiring patients to change TKI.ResultsFifty‐one patients were treated with ponatinib (median dose, 45 mg/day). Median age was 48 years (range, 21–75); 30 (59%) had baseline cardiovascular comorbidities. Median treatment duration was 13 months (range, 2–25). Fourteen patients (28%) discontinued ponatinib because of toxicities, 36 (71%) after the Food and Drug Administration warning/study closure, and one for noncompliance. Dasatinib was the most frequently chosen second‐line TKI (n = 34; 66%). Among 46 patients evaluable at 6 months, 44 (96%) achieved CCyR, 37 (80%) major molecular response, 28 (61%) MR4, and 21 (46%) MR4.5. The cumulative 6‐month rates of CCyR, major molecular response, MR4, and MR4.5 were 96%, 78%, 50%, and 36%, respectively. Durable MR4 ≥24 or ≥60 months was observed in 67% and 51% of patients, respectively. The 24‐month event‐free survival rate was 97%. After a median follow‐up of 128 months, the 10‐year overall survival rate was 90%. Eight patients (16%) had serious grade 2 to 3 cardiovascular adverse events, leading to permanent discontinuation in five (10%).ConclusionPonatinib yielded high cytogenetic and molecular responses in newly diagnosed chronic myeloid leukemia in chronic phase. Its use in the frontline setting is hindered by arterio‐/vaso‐occlusive and other severe toxicities.
Corporate biodiversity disclosure: The role of institutional factors and corporate governance
Authors: Hambali Ahmad , Adhariani Desi 
Published: May 2024

AbstractExtensive environmental degradation also has a negative impact on biodiversity, which plays a crucial role in both human survival and economic development. This condition has prompted various parties, including companies, to provide their contributions in preventing further severe damage. This study aims to examine the role of institutional factors, namely environmental performance and governance at the national level, as well as the role of corporate governance factors represented by board size, the proportion of independent directors, board diversity, and the presence of sustainability committees, in the corporate disclosure of biodiversity initiatives. The sample of this study comprises companies from 37 countries during the period 2016–2020. The study adopts a quantitative approach and utilizes analytical methods such as logistic regression and fixed‐effect panel data analysis. Research findings indicate that the national environmental performance as an institutional factor, board size, and the existence of sustainability committees as representatives of corporate governance mechanisms are positively associated with corporate biodiversity disclosure. Meanwhile, the national governance index and the proportion of independent directors have a negative impact. Lastly, in general, the proportion of female board members does not significantly affect biodiversity disclosure. However, additional tests reveal its significance in companies operating in the environmentally‐sensitive industries.
Conceptualizing avoidant/restrictive food intake disorder via an executive functioning lens
Authors: Richson Brianne N. , Abber Sophie R. , Wierenga Christina E. 
Published: May 2024

AbstractAvoidant/restrictive food intake disorder (ARFID) is a heterogeneous disorder wherein restrictive eating is primarily attributed to non‐shape/weight‐based reasons (e.g., sensory sensitivity) that empirical research continues to explore. Mounting evidence suggests that ARFID often presents alongside neurodevelopmental diagnoses (NDs) or divergent neurodevelopment broadly. Executive functioning (EF) differences often characterize divergent neurodevelopmental trajectories. Additionally, restrictive eating in anorexia nervosa has been conceptualized as related to EF factors (e.g., set shifting). Given the neurodevelopmental phenotype that may be associated with ARFID and the role of EF in anorexia nervosa, this paper proposes EF as a potentially important, yet understudied factor in ARFID pathology. We posit that various observed ARFID behavioral/cognitive tendencies can be conceptualized in relation to EF differences. We contextualize commonly observed ARFID presentations within “core” EF components (i.e., cognitive flexibility, working memory, inhibitory control), leading to hypotheses about EF in ARFID. Finally, we offer additional considerations/directions for future research on EF in ARFID. Increased research on EF in ARFID is needed to consider this potential common factor in the etiology and maintenance of this heterogeneous disorder. We aim to promote further consideration of EF in ARFID etiology, maintenance, and treatment‐outcome research.Public SignificanceThis article proposes that aspects of executive functioning (EF) may play a role in the onset and maintenance of avoidant/restrictive food intake disorder (ARFID), although this notion is largely untested by existing research. Further research on the role of EF in ARFID may assist with refining models and treatments for this heterogeneous disorder.
The impact of Ethiopian Green Legacy Initiative (GLI) on landscape functionality and plant species diversity in Lake Hawassa watershed, Ethiopia
Authors: Demisse Bezawit A. , Dittoh Saa , Salifu Eliasu , Moges Michael M. , Belete Mulugeta Dadi 
Published: May 2024

AbstractAs one of the responses to the global commitments against climate change, the Ethiopian Government launched a nationwide Green Legacy Initiative (GLI) in 2019, which largely focused on forest tree plantations with some inclusion of fruit trees. Despite its tremendous efforts and investments, its effectiveness and impacts have not been studied. This paper attempted to address this necessity by conducting a cross‐sectional quasi‐experiment in three randomly selected woredas/districts of Lake Hawassa Watershed from August 20 to September 2, 2023. The research hypothesized the likely impacts of GLI on four dependent variables (hydrological regulation, soil stability, nutrient cycling and plant species diversity). To achieve this, the research considered the two variants of GLI practices (plantation with and without soil and water conservation measures) and the corresponding control sites. Having three sites and three treatments with five replications, the study involved a total of forty‐five quadrats of the same size (20 m × 20 m). The first three parameters were analysed using the landscape functionality analysis method, while the fourth employed Shannon's diversity index. Results of ANOVA showed that, on average 87% of randomly selected quadrats were found to significantly improve the local hydrology (runoff potential) (≈ 83.3% with Av. p = 0.012), soil stability (≈100% with Av. p = 0.002), nutrient cycling (≈83.3% with Av. p = 0.017) and plant species diversity (≈83.3% with Av. p = 0.012). The research revealed positive results from the Ethiopian Green Legacy Initiative. The small number of samples is acknowledged as a limitation of the research.
Sex‐specific impact of psychosocial stress on hematopoiesis and blood leukocytes
Authors: Dolfi Bastien , Gallerand Alexandre , Caillot Zakariya , Castiglione Alexia , Zair Fairouz N. , Leporati Lorlana , Giacchero Margaux , Goës Eloïse , Strazzulla Axelle , Dombrowicz David , Guinamard Rodolphe R. , Bertola Adeline , Ivanov Stoyan 
Published: May 2024

AbstractStress exposure has been shown to modulate innate and adaptive immune responses. Indeed, stress favors myelopoiesis and monocyte generation and contributes to cardiovascular disease development. As sex hormones regulate innate and adaptive immune responses, we decided to investigate whether stress exposure leads to a different immune response in female and male mice. Our data demonstrated that psychosocial stressinduced neutrophilia in male, but not female mice. Importantly, we identified that B‐cell numbers were reduced in female, but not male mice upon exposure to stress. Thus, our study revealed that the stress‐induced immune alterations are sex‐dependent, and this is an important feature to consider for future investigations.
Synthesis of Molsidomine and Mesocarb Analog via Mechanochemistry
Authors: Pétry Nicolas , Bantreil Xavier , Lamaty Frédéric 
Published: May 2024

AbstractIminosydnones (ImSyds) have renowned biological activities and attractive chemical properties for chemical biology. However, access to N6‐functionalized iminosydnones involves tricky and hazardous procedures. Thanks to an innovative mechanochemical strategy using 1,1’‐carbonyldiimidazole (CDI) as an activating agent, a straightforward synthesis of molsidomine and of a mesocarb analog, two bioactive iminosydnones, was achieved. The whole process, involving 4 linear steps, was carried out in the solid state by ball‐milling and with safe reagents, offering efficient and sustainable access to N‐carbonylated iminosydnones, in agreement with the principles of green chemistry.
Vertical‐horizontal‐context‐based high numerical precision synthesis of masked line‐scan X‐ray image
Authors: Xiong Tianzhong , Ye Wenhua 
Published: May 2024

AbstractMaterial identification based on R_value (Transparency natural logarithm ratio of low‐energy to high‐energy.) of line‐scan dual‐energy X‐ray transmission (DE‐XRT) has a good prospect for industrial application. Unfortunately, the DE‐XRT signals before attenuation within the material range cannot be directly measured, whereas their precision has essential effect on R_value. Therefore, a vertical‐horizontal‐context‐based signal synthesis method was proposed to rebuilt incomplete/masked image, which takes the filtered signals outside the material range as the reference context, and takes into account the vertical (forward/column/Y) and horizontal (scanning/row/X) anisotropy. The vertical is a time series with continuity of signal trend; the horizontal is a spatial characteristic with the fluctuation synchronization within the same row signals. The vertical curves are synthesized one by one, thus extending to the whole surface. The special rigorous synthesis evaluations of curve synthesis difference and surface synthesis difference were also proposed. Experimental results show that the tow evaluations are both only around 0.0007, and it only takes 35 ms to complete the surface synthesis of 119 × 119 pixels on the CPU with 3.4 GHz main frequency. This high numerical precision can match the similarly filtered signals after attenuation so as to improve the accuracy of R_value. And this, together with calculation real‐time, can promote the application of industrial inline material identification.
Impact failure and disaster processes associated with rockfalls based on three‐dimensional discontinuous deformation analysis
Authors: Liu Guoyang , Zhong Zhirui , Ye Tangjin , Meng Jin , Zhao Shengze , Liu Junjie , Luo Shouyi 
Published: May 2024

AbstractRockfalls, a common geohazard in mountainous areas, have destructive impact capacity and may cause failure of dangerous rock masses in their runout range. For slope risk assessment, a thorough understanding of the impact failure processes and dynamic characteristics associated with rockfall movements is necessary. The aim of this study is to investigate the impact of rockfall failure behaviours and disaster processes on the dangerous rock mass along the way through three‐dimensional discontinuous deformation analysis (3D DDA). To validate the reliability and applicability of 3D DDA, numerous laboratory experiments are performed on the impact of downward moving blocks on the unstable block and block system (i.e. single block–single block, single block–block system and block column–block system models) by comparing the displacements, kinetic energies and movement states of blocks. Using the G318 national road in Tibet as an example, 3D DDA simulates the impact and disaster processes associated with upper rockfalls sourced from a complete giant block and multiple discrete blocks on lower dangerous rock mass. Further, rockfall failure modes, movement characteristics, block interactions and impact phenomena are investigated. Results show that 3D DDA can effectively simulate block movement and impact interaction. The upper rockfalls impact the initially stable lower dangerous rock mass, which is the triggering factor for failure of the lower dangerous rock mass. The blocks from the upper rockfalls interact and merge to move downward, increasing the total volume and impact capacity of the rockfalls. It has been discovered that the rockfall disaster caused by the impact of an upper rockfall comprising discrete blocks on a lower dangerous rock mass is more severe than that resulting from the impact of a complete block. Overall, the results of this research can be used to help predict and prevent rockfall disasters.
Intraspecific Variation in Mercury Contamination of Alligator Snapping Turtles (Macrochelys temminckii)
Authors: Rosenbaum David , Montaña Carmen G. , Zhang Yanli , Chumchal Matthew M. , Saenz Daniel , Schalk Christopher M. 
Published: May 2024

Abstract
Macrochelys temminckii (alligator snapping turtle) is an aquatic turtle endemic to the southeastern United States that was proposed for listing under the Endangered Species Act in 2021. In the present study we analyzed total mercury (THg) concentrations in skeletal muscle, tail clips, and nail tissue of 93 M. temminckii sampled from 14 waterbodies in eastern Texas (USA). Our objectives were to assess (1) the degree of correlation between internal tissue (skeletal muscle and tail clip samples) and keratin (nail samples), (2) the influence of ecological factors (turtle size and waterbody/sampling site) on THg concentrations, and (3) whether THg concentrations were high enough to pose a risk to human consumers. The mean (±SE) THg concentrations of muscle and nail were 1.16 ± 0.08 μg/g dry weight and 4.21 ± 0.24 μg/g dry weight, respectively, and THg concentrations were highly dependent on the sampling site. The THg concentrations of nails were correlated with muscle concentrations (R2 = 0.56, p &lt; 0.001). The effect of body size on THg concentrations varied by sampling site, indicating that size is not a good predictor of Hg concentration across sites. Finally, THg concentrations in M. temminckii of eastern Texas were high enough to pose a potential risk to human health based on US Environmental Protection Agency dietary guidelines. Environ Toxicol Chem 2024;43:1903–1913. © 2024 SETAC. This article has been contributed to by U.S. Government employees and their work is in the public domain in the USA.
The circulating IL‐35+ regulatory B cells are associated with thyroid associated opthalmopathy
Authors: Li Qian , Yang Cuixia , Liu Cheng , Zhang Yuehui , An Ningyu , Ma Xiumei , Zheng Yang , Cui Xiaomin , Li Qian 
Published: May 2024

AbstractBackgroundThyroid‐associated ophthalmopathy (TAO) is the most common orbital disease in adults, potentially leading to disfigurement and visual impairment. However, the causes of TAO are not fully understood. IL‐35+B cells are a newly identified regulatory B cells (Bregs) in maintaining immune balance in various autoimmune diseases. Yet, the influence of IL‐35+Bregs in TAO remains unexplored.MethodsThis study enrolled 36 healthy individuals and 14 TAO patients. We isolated peripheral blood mononuclear cells and stimulated them with IL‐35 and CpG for 48 h. Flow cytometry was used to measure the percentages of IL‐35+Bregs.ResultsThe percentage of circulating IL‐35+Bregs was higher in TAO patients, and this increase correlated positively with disease activity. IL‐35 significantly increased the generation of IL‐35+Bregs in healthy individuals. However, B cells from TAO patients exhibited potential impairment in transitioning into IL‐35+Breg phenotype under IL‐35 stimulation.ConclusionsOur results suggest a potential role of IL‐35+Bregs in the development of TAO, opening new avenues for understanding disease mechanisms and developing therapeutic approaches.
Varicella zoster virus‐induced autophagy in human neuronal and hematopoietic cells exerts antiviral activity
Authors: Heinz Johanna L. , Hinke Daniëla M. , Maimaitili Muyesier , Wang Jiayi , Sabli Ira K. D. , Thomsen Michelle , Farahani Ensieh , Ren Fanghui , Hu Lili , Zillinger Thomas , Grahn Anna , von Hofsten Joanna , Verjans Georges M. G. M. , Paludan Søren R. , Viejo‐Borbolla Abel , Sancho‐Shimizu Vanessa , Mogensen Trine H. 
Published: May 2024

AbstractAutophagy is a degradational pathway with pivotal roles in cellular homeostasis and survival, including protection of neurons in the central nervous system (CNS). The significance of autophagy as antiviral defense mechanism is recognized and some viruses hijack and modulate this process to their advantage in certain cell types. Here, we present data demonstrating that the human neurotropic herpesvirus varicella zoster virus (VZV) induces autophagy in human SH‐SY5Y neuronal cells, in which the pathway exerts antiviral activity. Productively VZV‐infected SH‐SY5Y cells showed increased LC3‐I‐LC3‐II conversion as well as co‐localization of the viral glycoprotein E and the autophagy receptor p62. The activation of autophagy was dependent on a functional viral genome. Interestingly, inducers of autophagy reduced viral transcription, whereas inhibition of autophagy increased viral transcript expression. Finally, the genotype of patients with severe ocular and brain VZV infection were analyzed to identify potential autophagy‐associated inborn errors of immunity. Two patients expressing genetic variants in the autophagy genes ULK1 and MAP1LC3B2, respectively, were identified. Notably, cells of both patients showed reduced autophagy, alongside enhanced viral replication and death of VZV‐infected cells. In conclusion, these results demonstrate a neuro‐protective role for autophagy in the context of VZV infection and suggest that failure to mount an autophagy response is a potential predisposing factor for development of severe VZV disease.