bluuebunny/crossref_metadata_2025_split huggingface dataset:
Identifying Symptom Profiles of Depression and Anxiety in Patients with an Acute Coronary Syndrome Using Latent Class and Latent Transition Analysis
Authors: Tisminetzky Mayra , Bray Bethany C. , Miozzo Ruben , Aupont Onesky , McLaughlin Thomas J. 
Published: December 2011

Objective: To identify symptom profiles of depression and anxiety in patients with an acute coronary syndrome (ACS), to examine changes in symptom profiles over time, and finally, to examine the effects of age and sex on patients' symptom profiles. Methods: One hundred ACS patients with mild to severe symptoms of depression and/or anxiety at 1 month post-hospital discharge were enrolled in a randomized trial of cognitive behavioral therapy. Latent class and latent transition analyses were used to identify symptom profiles and describe change over the time in profile membership. Results: A two-class solution was selected to describe depression and anxiety symptom profiles. Class I (76% of patients at baseline) was labeled “depression and some anxiety symptoms.” Class II (24% of patients at baseline) was labeled “anxiety and some depression symptoms.” Approximately 25% of patients in the treatment condition transitioned from the depression and some anxiety symptoms class to the anxiety and some depression symptoms class at follow-up compared to 10% of patients in the control condition at follow-up; nearly 50% of patients in the control condition showed worsening of symptoms as compared to 28% in the treatment condition. Results suggested age differences in the probabilities of transitioning between the classes; older patients were more likely to continue having depression and some anxiety symptoms at the time of follow-up. Conclusions: Identifying symptom profiles of depression and anxiety in patients with an ACS may improve diagnostic practices and help to design tailored interventions.
Bacteriological and Physicochemical Analyses of the Raw and Treated Water of Saidabad Water Treatment Plant, Dhaka
Authors: Hossain M Alamgir , Begum Tahmina , Fakhruddin ANM , Khan Sirajul Islam 
Published: December 2011

Bacteriological and physicochemical parameters of the raw and treated water of the Saidabad Water Treatment Plant were analysed during the period January through December 2004. It was found that during dry season Sitalakhya River water was adversely polluted and most of the bacteriological and physicochemical parameters increased to an alarming level. Total coliform and thermotolerant-coliform counts of raw water were highest in months of January through March and lowest during the months of April through November. Ammonia concentration of the raw water was very high (3.08-7.06 mg/l) during the dry months from January to April that coincided with high (2.57-6.08 mg/l) ammonia contamination in the treated water. The others physicochemical parameters like turbidity, conductivity, total dry solid (TDS), hardness and alkalinity were high during the dry months. The residual chlorine in treated water was always below 0.50 mg/l. The study clearly indicated that the load of coliform increased when the concentration of ammonia was high in raw water that, to some extent, influenced the aesthetic properties of the treated water like turbidity, colour, taste, odour, alkalinity, TDS, etc. In spit of that the treated water could be used for domestic and drinking purposes for most of the year. Keywords: Water quality, Total coliform, Thermotolerant-coliform, Ammonia, Physicochemical properties, Residual chlorine DOI: http://dx.doi.org/10.3329/bjm.v23i2.878 Bangladesh J Microbiol, Volume 23, Number 2, December 2006, pp 133-136
Isolation and Identification of Indigenous Bakers' Yeast
Authors: Jahan Nasrin , Azmuda Nafisa , Khan Anisur Rahman 
Published: December 2011

This investigation was performed to isolate and identify indigenous bakers' yeast. Initially, 75 yeast isolates were collected from different sources such as decomposed fruits, fermented rice and fermented fruit juices. Twenty five isolates were selected by primary screening; among them, ten isolates were considered as potential bakers' yeasts on the basis of their ability to produce high amount of biomass and leavening action. Two isolates were identified as Saccharomyces cerevisiae, seven as Saccharomyces species and only one as Kluyveromyces species. These isolates have sufficient potential to be produced commercially after evaluation of some baking parameters like texture and organoleptic properties.Keywords: Bakers' yeast, Saccharomyces cerevisiae, Cell mass, Leavening actionDOI: http://dx.doi.org/10.3329/bjm.v24i1.1241 Bangladesh J Microbiol, Volume 24, Number 1, June 2007, pp 65-66
Effect of Nutrients and Cellobiose Octaacetate on Cellulolytic Enzyme Productions by <i>Streptomyces albolongus</i>
Authors: Das Sanit Kumar , Alam M Zobaidul , Manchur M Abul , Anwar M Nural 
Published: December 2011

The cellulolytic mesophilic isolate Streptomyces albolongus (A5) was used to determine the effect of nitrogen and carbon sources on the production of cellulolytic enzymes using cellobiose octaacetate (COA) as an inducer. The isolate was able to degrade various cellulosic carbon sources. However, the rate of degradation, production of extracellular protein, reducing sugar, saccharification and production of enzyme were enhanced when 0.6% COA was used as an inducer in addition to the main substrate. Among the nitrogen sources tested, beef extract showed maximum production of the enzyme (136.7 U/ml CMCase) in Winstead's medium. The enzyme production was further enhanced in the medium supplemented with 0.6% COA, which corresponded to 154.69 U/ml CMCase activity. Among the carbon sources, carboxymethylcellulose (CMC) was found to be the best carbon source and again supplementation of the medium with 0.6% COA enhances CMCase production. Other than CMCase activity, the organism also produced appreciable levels of filter paper cellulase (FPase), avicelase and Ã¢-glucosidase activities.Keywords: Streptomyces albolongus, Carboxymethylcellulose (CMC), Cellobiose octaacetate (COA), InductionDOI: http://dx.doi.org/10.3329/bjm.v24i1.1243 Bangladesh J Microbiol, Volume 24, Number 1, June 2007, pp 70-72
Antimicrobial Activity of Crude Extract Obtained from the Root of <i>Plumbago zeylanica</i>
Authors: Rahman M Shafiqur , Anwar M Nural 
Published: December 2011

Ethanolic extract of Plumbago zeylanica root was investigated for its antimicrobial activities against 11 human pathogenic bacteria and 6 phytopathogenic fungi using disc diffusion method and poisoned food technique respectively. The extract exhibited good antibacterial and antifungal activities against the test organisms. Among the test bacteria, Vibrio cholerae was found to be the most sensitive to the extract showing the highest diameter of zone of inhibition and lowest minimum inhibitory concentration (MIC) value (200 Î¼g/ml). The extract was also very effective against Escherichia coli and Pseudomonas aeruginosa showing MIC value of 250 Î¼g/ml. Among the phytopathogenic fungi tested, Curvularia lunata exhibited the highest sensitivity to the extract with an MIC value of 150 Î¼g/ml, which was followed next by Colletotrichum corchori and Fusarium equiseti (MIC value 250 Î¼g/ml). The root extract from P. zeylanica seems promising since it showed both antibacterial and antifungal activities. Keywords: Antimicrobial activity, Plumbago zeylanica, Ethanolic extract, Minimum inhibitory concentration (MIC)DOI: http://dx.doi.org/10.3329/bjm.v24i1.1244 Bangladesh J Microbiol, Volume 24, Number 1, June 2007, pp73-75
Trogocytosis Is a Gateway to Characterize Functional Diversity in Melanoma-Specific CD8+ T Cell Clones
Authors: Uzana Ronny , Eisenberg Galit , Sagi Yael , Frankenburg Shoshana , Merims Sharon , Amariglio Ninette , Yefenof Eitan , Peretz Tamar , Machlenkin Arthur , Lotem Michal 
Published: December 2011

Abstract
Trogocytosis, the transfer of membrane patches from target to immune effector cells, is a signature of tumor–T cell interaction. In this study, we used the trogocytosis phenomenon to study functional diversity within tumor-specific T cell clones with identical TCR specificity. MART-126–35–specific CD8 T cell clones, which differed in their trogocytosis capacity (low [2D11], intermediate [2G1], high [2E2]), were generated from melanoma patients. Functional evaluation of the clones showed that the percentage of trogocytosis-capable T cells closely paralleled each clone’s IFN-γ and TNF-α production, lysosome degranulation, and lysis of peptide-pulsed targets and unmodified melanoma. The highly cytotoxic 2E2 clone displayed the highest TCR peptide binding affinity, whereas the low-activity 2D11 clone showed TCR binding to peptide-MHC in a CD8-dependent manner. TCR analysis revealed Vβ16 for clones 2E2 and 2G1 and Vβ14 for 2D11. When peptide-affinity differences were bypassed by nonspecific TCR stimulation, clones 2E2 and 2D11 still manifested distinctive signaling patterns. The high-activity 2E2 clone displayed prolonged phosphorylation of ribosomal protein S6, an integrator of MAPK and AKT activation, whereas the low-activity 2D11 clone generated shorter and weaker phosphorylation. Screening the two clones with identical TCR Vβ by immunoreceptor array showed higher phosphorylation of NK, T, and B cell Ag (NTB-A), a SLAM family homophilic receptor, in clone 2E2 compared with 2G1. Specific blocking of NTB-A on APCs markedly reduced cytokine production by CD8 lymphocytes, pointing to a possible contribution of NTB-A costimulation to T cell functional diversity. This finding identifies NTB-A as a potential target for improving anti-cancer immunotherapy.
IL-27 Enhances LPS-Induced Proinflammatory Cytokine Production via Upregulation of TLR4 Expression and Signaling in Human Monocytes
Authors: Guzzo Christina , Ayer Amit , Basta Sameh , Banfield Bruce W. , Gee Katrina 
Published: December 2011

AbstractIL-27, which is produced by activated APCs, bridges innate and adaptive immunity by regulating the development of Th cells. Recent evidence supports a role for IL-27 in the activation of monocytic cells in terms of inflammatory responses. Indeed, proinflammatory and anti-inflammatory activities are attributed to IL-27, and IL-27 production itself is modulated by inflammatory agents such as LPS. IL-27 primes LPS responses in monocytes; however, the molecular mechanism behind this phenomenon is not understood. In this study, we demonstrate that IL-27 priming results in enhanced LPS-induced IL-6, TNF-α, MIP-1α, and MIP-1β expression in human primary monocytes. To elucidate the molecular mechanisms responsible for IL-27 priming, we measured levels of CD14 and TLR4 required for LPS binding. We determined that IL-27 upregulates TLR4 in a STAT3- and NF-κB–dependent manner. Immunofluorescence microscopy revealed enhanced membrane expression of TLR4 and more distinct colocalization of CD14 and TLR4 upon IL-27 priming. Furthermore, IL-27 priming enhanced LPS-induced activation of NF-κB family members. To our knowledge, this study is the first to show a role for IL-27 in regulating TLR4 expression and function. This work is significant as it reveals new mechanisms by which IL-27 can enhance proinflammatory responses that can occur during bacterial infections.
Mice with Mutations in Fas and Fas Ligand Demonstrate Increased Herpetic Stromal Keratitis following Corneal Infection with HSV-1
Authors: Morris Jessica E. , Zobell Stephanie , Yin Xiao-Tang , Zakeri Hamideh , Summers Bretton C. , Leib David A. , Stuart Patrick M. 
Published: December 2011

AbstractHSV-1 infection of the cornea leads to a potentially blinding immunoinflammatory lesion of the cornea, termed herpetic stromal keratitis. It has also been shown that one of the factors limiting inflammation of the cornea is the presence of Fas ligand (FasL) on corneal epithelium and endothelium. In this study, the role played by FasL expression in the cornea following acute infection with HSV-1 was determined. Both BALB/c and C57BL/6 (B6) mice with HSV-1 infection were compared with their lpr and gld counterparts. Results indicated that mice bearing mutations in the Fas Ag (lpr) displayed the most severe disease, whereas the FasL-defective gld mouse displayed an intermediate phenotype. It was further demonstrated that increased disease was due to lack of Fas expression on bone marrow-derived cells. Of interest, although virus persisted slightly longer in the corneas of mice bearing lpr and gld mutations, the persistence of infectious virus in the trigeminal ganglia was the same for all strains infected. Further, B6 mice bearing lpr and gld mutations were also more resistant to virus-induced mortality than were wild-type B6 mice. Thus, neither disease nor mortality correlated with viral replication in these mice. Collectively, the findings indicate that the presence of FasL on the cornea restricts the entry of Fas+ bone marrow-derived inflammatory cells and thus reduces the severity of HSK.
Case report: Dot-in-circle sign - An MRI and USG sign for "Madura foot"
Authors: Sen Anitha , Pillay Rajesh Subramonia 
Published: December 2011

AbstractMycetoma is a chronic granulomatous disease that is more common in tropical than in temperate regions. Early diagnosis is important due to the therapeutic implications. Although biopsy and microbiological culture provide definitive diagnosis, they are time-consuming procedures and may not be able to provide a definite diagnosis in cases of fastidious organisms. The "dot-in-circle" sign has recently been proposed as a highly specific magnetic resonance imaging (MRI) and ultrasonography (USG) sign of mycetoma, which may allow a noninvasive as well as early diagnosis. We present a case of histologically proven mycetoma that demonstrated this sign.
Technical note: Real-time sonoelastography evaluation of achilles tendon
Authors: Palle Lalitha , Reddy MCH Balaji , Reddy K Jagannath , Kumari M Vijaya 
Published: December 2011

AbstractSonoelastography (SE) is a new USG-based technique that is being used to assess the elasticity and pliability of various tissues and lesions. We evaluated normal and abnormal Achilles tendons and correlated SE findings with those of high-resolution USG. This article briefly discusses the principle and technique of sonoelastography and the variations in elasticity and pliability between normal and abnormal Achilles tendons.
A Model for Worksite Cancer Prevention: Integration of Health Protection and Health Promotion in the WellWorks Project
Authors: Sorensen Glorian , Himmelstein Jay S. , Hunt Mary Kay , Youngstrom Richard , Hebert James R. , Hammond S. Katharine , Palombo Ruth , Stoddard Anne , Ockene Judith K. 
Published: December 2011

Objectives. To describe a theoretic approach and rationale for the integration of health protection and health promotion in worksite cancer prevention programs and to describe an intervention study designed to implement this integration. Methods. Twenty-four worksites were recruited to participate in this randomized, controlled study. The theoretically based intervention model integrates health promotion and health protection through (1) joint worker-management participation in program planning and implementation, (2) consultation on worksite changes, and (3) educational programs targeting health behavior change. Results. Although the primary purpose of this paper is to describe a theoretic approach to the integration of health promotion and health protection, preliminary results are also noted. In these predominantly manufacturing worksites, many workers faced the double jeopardy of exposures to occupational carcinogens and personal risks such as smoking or poor dietary habits. Production workers' job responsibilities frequently limited their full participation. Barriers to participation were identified early in the project, and strategies were developed to facilitate maximal worker involvement and worksite changes. Conclusions. Lifestyle changes such as smoking cessation or dietary changes may be more effectively promoted among blue collar audiences when programs also encourage management actions to reduce occupational exposures. Public health professionals trained in health promotion and health protection must work together to effectively address the health concerns of this population.
The Conceptualization and Measurement of Perceived Wellness: Integrating Balance across and within Dimensions
Authors: Adams Troy , Bezner Janet , Steinhardt Mary 
Published: December 2011

Purpose. The impact of individual perceptions on health is well-established. However, no valid and reliable measure of individual wellness perceptions exists. Therefore, the purpose was to introduce a measure called the Perceived Wellness Survey (PWS). Design. Convenience sampling facilitated recruitment of a sample large enough to perform factor analysis with adequate power (.85). The appropriateness of factor analysis is supported by Bartlett's test ( χ2 = 7110, p ≤ .01) and the Kaiser-Meyer-Olkin measure of sampling adequacy (.91). Setting. The sample (n = 558) was composed of 3M Inc. employees from multiple sites in Austin, Texas (n = 393); employees from MuRata Electronics, Inc., College Station, Pennsylvania (n = 53); and students enrolled at the University of Texas at Austin (n = 112). Subjects. Racial, gender, and age distribution was, respectively, 6.3% African-American (n = 35), 8.2% Asian (n = 46), 73.3% Caucasian (n = 409), 9.5% Hispanic (n = 53), and 2.7% other (n = 15); 47.8% male (n = 267), and 52.2% female (n = 291); and 36.8 years. Measures. Measures included the Perceived Wellness Survey, and two additional versions of the Perceived Wellness Survey designed to measure both discriminant and face validity. Perceived Wellness Survey subscales include physical, spiritual, intellectual, psychological, social, and emotional dimensions. Results. All subscales were correlated ( p ≤ . 05) with the Perceived Wellness Survey composite and with each other. Evidence of internal consistency (α = .88 to .93), and discriminant, face, and factorial validity was provided. Finally, the Perceived Wellness Survey appears to be a unidimensional scale. Conclusion. The unidimensional nature of the Perceived Wellness Survey suggests that perceptions of wellness in various dimensions are intertwined by their affective nature. The Perceived Wellness Survey appears to be reasonably valid and reliable; however, further research is needed.
Development of a School-Based Nutrition Intervention for High School Students: Gimme 5
Authors: Nicklas Theresa A. , Johnson Carolyn C. , Farris Rosanne , Rice Rochelle , Lyon Lisa , Shi Runhua 
Published: December 2011

Purpose. To describe a 4-year intervention targeting fruit/vegetable consumption by high school students. Design. This is a cohort study involving six pairs of schools (n = 12) matched on gender, race, enrollment, and location with schools randomly assigned within pairs to intervention or control conditions. Setting. Twelve Archdiocese of New Orleans high schools. Subjects. Cohort was defined as students (n = 2339) who were ninth-graders in the 1993–94 school year who provided baseline data. Intervention. Four components of the intervention are: (1) school-wide media-marketing campaign, (2) school-wide meal and snack modification, (3) classroom workshops and supplementary subject matter activities, and (4) parental involvement. Measures. Focus groups were conducted for target population input and program development. Process evaluation included student feedback on media-marketing intervention materials and activities reported here. Process measures also included school meal participation, student characteristics, and verification of intervention activities. Results. Focus groups indentified barriers to increased consumption of fruit and vegetables as lack of availability, variety, and inconsistency in taste. Student attitudes were favorable regarding a school program to improve diet and parental involvement. Low consumption of fruits/vegetables was reported. After a 2-month school-wide program introduction utilizing various media-marketing materials and activities, 93% of students were aware of the program and 96% could identify the healthy eating message. Conclusions. Program development can be guided and enriched by student input via focus groups. Media-marketing activities effectively delivered health messages and attracted students' attention. Materials and activities used were acceptable channels for increasing awareness, positive attitudes, and knowledge about fruits/vegetables.
FLOCCULATION, REINFORCEMENT, AND GLASS TRANSITION EFFECTS IN SILICA-FILLED STYRENE-BUTADIENE RUBBER
Authors: Robertson C. G. , Lin C. J. , Bogoslovov R. B. , Rackaitis M. , Sadhukhan P. , Quinn J. D. , Roland C. M. 
Published: December 2011

Abstract
The introduction of silanes to improve processability and properties of silica-reinforced rubber compounds is critical to the successful commercial use of silica as a filler in tires and other applications. The use of silanes to promote polymer–filler interactions is expected to limit the development of a percolated filler network and may also affect the mobility of polymer chains near the particles. Styrene-butadiene rubber (SBR) was reinforced with silica particles at a filler volume fraction of 0.19, and various levels of filler–filler shielding agent (n-octyltriethoxysilane) and polymer–filler coupling agent (3-mercaptopropyltrimethoxysilane) were incorporated. Both types of silane inhibited the filler flocculation process during annealing the uncured rubber materials, thus reducing the magnitude of the Payne effect. In contrast to the significant reinforcement effects noted in the strain-dependent shear modulus, the bulk modulus from hydrostatic compression was largely unaltered by the silanes. Addition of polymer–filler linkages using the coupling agent yielded bound rubber values up to 71%; however, this bound rubber exhibited glass transition behavior which was similar to the bulk SBR response, as determined by calorimetry and viscoelastic testing. Modifying the polymer–filler interface had a strong effect on the nature of the filler network, but it had very little influence on the segmental dynamics of polymer chains proximate to filler particles.
Impact of TP53 Codon 72 and MDM2 Promoter 309 Allelic Dosage in a Moroccan Population with Hepatocellular Carcinoma
Authors: Ezzikouri Sayeh , El Feydi Abdellah Essaid , Afifi Rajae , Benazzouz Mustapha , Hassar Mohammed , Pineau Pascal , Benjelloun Soumaya 
Published: December 2011

Single-nucleotide polymorphisms (SNPs) in codon 72 of the TP53 gene (rs1042522) and in the promoter region of the MDM2 gene (SNP309; rs2279744) have been shown to play a role in the predisposition to many cancers. However, these findings were inconsistent in other tumor types, and ethnicity is suspected to be a critical factor influencing the effects of these SNPs on the cancer risk. The aim of the present study was to investigate whether these functional SNPs were associated with an enhanced risk of liver tumorigenesis in Moroccan patients. We have genotyped both polymorphisms in 96 patients with hepatocellular carcinoma (HCC) and 222 controls without HCC matched for age, gender and ethnicity by PCR-RFLP confirmed by sequencing. A joint effect between the MDM2 and TP53 polymorphisms and an increased risk of liver cancer was detected, with the odds ratio for the presence of both MDM2 309GG and TP53 72Pro/Pro genotypes being 10 (95% confidence interval 0.39-255.55). Interestingly, a significant increase in the HCC risk was observed when at least two deleterious alleles were present, indicating an allele dosage effect. There was no evidence for any association with early age of HCC onset when deleterious alleles of MDM2 SNP309 and TP53 Arg72Pro where present. Our findings suggest that the combination of TP53 72Pro and MDM2 309G polymorphisms enhance the risk of developing HCC. These results deserve further confirmation in other populations.