bluuebunny/crossref_metadata_2025_split huggingface dataset:
To share or not to share: When is influencer self‐disclosure perceived as appropriate?
Authors: Leite Fernanda Polli , Pontes Nicolas , Septianto Felix 
Published: May 2024

AbstractInfluencers' personal stories on social media can shape consumer behavior. Yet little is known about how intimacy, valence, and topic of self‐disclosure affect perceptions of credibility. In two studies, results reveal that intimate (vs. non‐intimate) self‐disclosure reduces perceived message appropriateness and influencer credibility, while positive (vs. negative) self‐disclosure enhances it. Furthermore, the effect of positive intimate self‐disclosure on appropriateness is stronger for topics related to mental health (vs. relationships). This research broadens the theoretical understanding of how consumers perceive influencer credibility by analyzing various dimensions of self‐disclosure, providing practical insights for integrating self‐disclosure into social media recommendations.
An Active and Versatile Electron Transport System for Cytochrome P450 Monooxygenases from the Alkane Degrading Organism Acinetobacter sp. OC4
Authors: Schultes Fabian Peter Josef , Welter Leon , Hufnagel Doreen , Heghmanns Melanie , Kasanmascheff Müge , Mügge Carolin 
Published: May 2024

AbstractCytochrome P450 monooxygenases (CYPs) are valuable biocatalysts for the oxyfunctionalization of non‐activated carbon‐hydrogen bonds. Most CYPs rely on electron transport proteins as redox partners. In this study, the ferredoxin reductase (FdR) and ferredoxin (FD) for a cytochrome P450 monooxygenase from Acinetobacter sp. OC4 are investigated. Upon heterologous production of both proteins independently in Escherichia coli, spectral analysis showed their reduction capability towards reporter electron acceptors, e. g., cytochrome c. The individual proteins’ specific activity towards cytochrome c reduction was 25 U mg−1. Furthermore, the possibility to enhance electron transfer by artificial fusion of the units was elucidated. FdR and FD were linked by helical linkers [EAAAK]n, flexible glycine linkers [GGGGS]n or rigid proline linkers [EPPPP]n of n=1–4 sequence repetitions. The system with a glycine linker (n=4) reached an appreciable specific activity of 19 U mg−1 towards cytochrome c. Moreover, their ability to drive different members of the CYP153A subfamily is demonstrated. By creating artificial self‐sufficient P450s with FdR, FD, and a panel of four CYP153A representatives, effective hydroxylation of n‐hexane in a whole‐cell system was achieved. The results indicate this protein combination to constitute a functional and versatile surrogate electron transport system for this subfamily.
In‐cell Catalysis by Tethered Organo−Osmium Complexes Generates Selectivity for Breast Cancer Cells
Authors: Coverdale J. P. C. , Bedford R. A. , Carter O. W. L. , Cao S. , Wills M. , Sadler P. J. 
Published: May 2024

AbstractAnticancer agents that exhibit catalytic mechanisms of action offer a unique multi‐targeting strategy to overcome drug resistance. Nonetheless, many in‐cell catalysts in development are hindered by deactivation by endogenous nucleophiles. We have synthesised a highly potent, stable Os‐based 16‐electron half‐sandwich (‘piano stool’) catalyst by introducing a permanent covalent tether between the arene and chelated diamine ligand. This catalyst exhibits antiproliferative activity comparable to the clinical drug cisplatin towards triple‐negative breast cancer cells and can overcome tamoxifen resistance. Speciation experiments revealed Os to be almost exclusively albumin‐bound in the extracellular medium, while cellular accumulation studies identified an energy‐dependent, protein‐mediated Os accumulation pathway, consistent with albumin‐mediated uptake. Importantly, the tethered Os complex was active for in‐cell transfer hydrogenation catalysis, initiated by co‐administration of a non‐toxic dose of sodium formate as a source of hydride, indicating that the Os catalyst is delivered to the cytosol of cancer cells intact. The mechanism of action involves the generation of reactive oxygen species (ROS), thus exploiting the inherent redox vulnerability of cancer cells, accompanied by selectivity for cancerous cells over non‐tumorigenic cells.
Importance of clinico‐pathologic correlation in rare, chronic infectious diseases: Actinomycetoma misdiagnosed as botryomycosis—A case report
Authors: Masuka Josiah Tatenda , Mthembu Luanda , Duze Khumo , Moodley Ameshin , Rikhotso Tshikani Norman , Mosam Anisa 
Published: May 2024

Key Clinical MessageThis case report explores the clinical journey of a patient initially diagnosed with botryomycosis, only to later reveal the underlying and rare condition of actinomycosis. The report highlights the challenges in getting to an accurate diagnosis, emphasizing the importance of considering uncommon pathologies, the utility of multi‐disciplinary teams and clinico‐pathologic correlation in clinical practice.
Preparation of Magnetically Recyclable MIL‐101‐immobilized Frustrated Lewis Pairs for the Reduction of Aldehydes and Ketones
Authors: Chen Miaomiao , Xue Han , Zhao Huili , Ji Min , Wang Min 
Published: May 2024

AbstractFrustrated Lewis pairs (FLPs), composed of spatially hindered Lewis acids and bases, are promising catalysts for the catalytic hydrogenation of unsaturated organic substrates, but the lack of reusability limits their development. The functionalization of solid materials with molecular FLP is a promising method for preparing heterogeneous FLP catalysts. In this work, a magnetically recyclable FLP catalyst was successfully prepared for the reductive carbonyl compounds to the corresponding alcohols. FLP of 2‐Ph2PPhCHO/B(C6F5)3 was grafted into NH2‐MIL‐101@Fe3O4 composite material through an aldehyde‐amine condensation reaction. The as‐prepared FLP‐NH‐MIL‐101@Fe3O4 exhibited remarkable catalytic activity for aldehyde/ketone carbonyl compounds. In addition, FLP‐NH‐MIL‐101@Fe3O4 displays outstanding magnetic recyclability and can be reused 8 times without loss of activity.
Selective Oxidations of Toluenes and Benzyl Alcohols by an Unspecific Peroxygenase (UPO)
Authors: Pogrányi Balázs , Mielke Tamara , Cartwright Jared , Unsworth William P. , Grogan Gideon 
Published: May 2024

AbstractUnspecific Peroxygenases (UPOs) have emerged as robust biocatalysts for selective oxygenation reactions, as they are easily produced at scale and require only hydrogen peroxide as the external oxidant. UPOs can catalyze the oxygenation of the primary benzylic carbons of toluenes to give alcohol, aldehyde and carboxylic acid products. They can also catalyze hydroxylation at the benzylic position of ethylbenzenes, and the subsequent oxidation of the secondary alcohols to ketones. In this study, we have investigated factors that affect the balance of products in UPO‐catalyzed benzylic oxygenations using a range of functionalised toluenes and ethyl benzenes, and a UPO from Agrocybe aegerita (rAaeUPO‐PaDa‐I‐H variant). The product distribution is dependent upon a mixture of steric and electronic effects and, in selected cases, controlling the reaction conditions permits products from each product series to be generated chemoselectively. In this way, electron poor toluenes were converted directly into carboxylic acids in isolated yields of 36–99 % on preparative scale.
Reactivity and Durability of Covalent Organic Frameworks Derived Co‐Based Hybrid Bifunctional Electrocatalysts for Zinc‐Air Batteries
Authors: Zhang Yuling L. , Xiao Longfei F. , Mo Yiping P. , Liu Guilin L. , Liu Shanshan S. , Lu Wangyang Y. 
Published: May 2024

AbstractDeveloping bifunctional non‐precious metal electrocatalysts of superior reactivity and durability is essential. Herein, we report a class of phthalocyanine‐based covalent organic frameworks as self‐sacrificial precursors derived Co‐based hybrid electrocatalysts for oxygen reduction reaction (ORR) and oxygen evolution reaction (OER). The fabricated Co‐COFs/CNT‐700 catalysts displayed highly efficient ORR properties with a half‐potential of 0.83 V, while its half‐wave potential in alkaline solution at a current density of 10 mA cm−2 is 1.70 V in the OER test, reflecting exceptional OER activity. Moreover, zinc‐air batteries assembled with Co‐COFs/CNT‐700 catalysts exhibit a marginally higher power density (114 mW cm2) than traditional Pt/C−IrO2 batteries in an air atmosphere, along with an enhanced cycling stability (5.1 % potential loss after 65 h). This work may pave a facile and efficient approach for fabricating electrocatalytic materials with controllably introduced metals and heteroatoms.
Combined selection for productivity, adaptability, and stability in corn genotypes for baby corn production
Authors: Nascimento Maxwel Rodrigues , de Melo Gérsia Gonçalves , de Oliveira Luciano Antonio , da Silva Alessandra Querino , da Silva Carlos Pereira , Ricardo dos Santos Paulo , Daher Rogério Figueiredo 
Published: May 2024

AbstractBaby corn is the name given to the female inflorescence of corn (Zea mays L.) before fertilization, being harvested in 2–3 days after the issuance of the styles‐stigmata. Currently, in Brazil, there is no specific corn cultivar for baby corn production, which leads to the use of popcorn and sweet corn cultivars because they are more accepted in the food industry. Therefore, the objective of this work was to estimate the genetic parameters and determine the efficiency of simultaneous selection based on productivity, adaptability, and stability of corn genotypes for baby corn production in the state of Espírito Santo, Brazil. The evaluations were conducted in 2019 on family properties in six municipalities in the state of Espírito Santo. Eleven corn genotypes were evaluated for baby corn production, being a double hybrid, four native varieties, and six commercial varieties. The design was randomized blocks with four repetitions each. The genetic parameters were estimated, which were obtained using the best linear unbiased prediction (BLUP), and the selection was carried out by the harmonic mean of the relative performance of genotypic values (HMRPGV). It was observed that the environments influenced the performance of the genotypes, configuring specific adaptation. The genotypes AG 1051, Aliança, and BR 106 presented the best performances in all the environments evaluated, considering, simultaneously, the productivity, adaptability, and stability of marketable ears. The HMRPGV method provided optimized selection of corn genotypes to produce baby corn with high productive potential, predictable behavior, and responsive to environmental stimuli.
Substitution mapping of yield‐related traits utilizing three Cybonnet rice × wild introgression libraries
Authors: Eizenga Georgia C. , Edwards Jeremy D. , Jackson Aaron K. , Huggins Trevis D. 
Published: May 2024

AbstractImproving rice (Oryza sativa L.) yields is a major objective of breeding programs worldwide. The Oryza rufipogon species complex (ORSC), which includes the rice ancestral species O. rufipogon Griff. and O. nivara S. D. Sharma & Shastry, is an underutilized resource. Using three phenotypically and genotypically diverse ORSC accessions identified as OrA, OrB, and OrC, three Cybonnet × ORSC chromosome segment substitution line (CSSL) libraries were developed to make this genepool more accessible to breeders. The objective was to characterize these libraries for 20 yield‐related traits to discover genes not currently deployed for rice improvement. Cybonnet and 212 CSSLs from these libraries were evaluated for 2 years in field studies for six agronomic, six panicle architecture, and eight seed traits. Across the three libraries, 62 CSSLs were found to be significantly different from Cybonnet for one or more traits. Of these, 27 CSSLs were significantly different for seed size traits. To ascertain the chromosome region and underlying candidate gene(s) causing these differences, substitution mapping was performed with previously reported genotypes. Mapping with the CSSLs, which had delayed heading under long days, revealed five known genes associated with rice flowering time pathways. The OsMADS50, RFT1, HD3A, SE1, and GHD7 genes were mapped in the OrB and OrC derived CSSLs but only OsMADS50 mapped in the OrA derived CSSLs. Employing this approach for the other 19 traits revealed 28 total candidate genes. A total of 12 of these genes are currently not deployed for yield enhancement. The introgressed ORSC regions associated with these genes are potential sources of novel variation for rice improvement.
Progress toward impact at scale of orange‐fleshed sweetpotato in Ghana
Authors: Abidin Putri E. , Dorgbetor Isaac K. , Adofo Kwadwo , Acheremu Kwabena , Adjebeng‐Danquah Joseph , Conduah Isaac , Ebregt Marjolein , Adekambi Souleimane A. , Carey Edward E. 
Published: May 2024

AbstractSweetpotato (Ipomoea batatas L.) was known as a minor root crop in Ghana. Starting in 2010, the International Potato Center (CIP) and multiple partners implemented orange‐fleshed sweetpotato (OFSP) projects to reposition this crop in Ghana. CIP‐led projects from 2010 to 2021 were identified as Research for Development Initiative projects. These projects consisted of (i) new variety development and commercial seed systems (Sweetpotato Action for Security and Health in Africa: 2009–2019); (ii) OFSP products for business development, breeding‐seed system linkages, strategic awareness for demand creation, sensitization, capacity building, advocacy, and strengthen public‐private partnerships (Jumpstarting OFSP: 2014–2017); (iii) research on shelf‐life and appropriate storage practices (two U.S. Agency for International Development's Office of U.S. Foreign Disaster Assistance: 2013–2015 and 2017–2018); and (iv) innovative on‐farm variety testing using the ClimMob‐CitizenScience method (Triadic Comparison of Technologies– roots, tubers, and bananas scaling: 2020–2021). In November 2020, CIP withdrew from Ghana, and the scaling partner, the Reputed Agriculture 4 Development Foundation, led this project up to the end. Strengthened partnerships have driven the expansion of OFSP into value chains. Key partners driving changes were private sector producers and processors, small‐holder farmers, Council for Scientific and Industrial Research institutes, universities, Women in Agricultural Development, Government Extension, Ghana Health Service, and Ghana School Feeding Program. AGRA OFSP for scaling in Ghana (2021–2022) revealed OFSP notably contributed to food security, health, and wealth. It fits in the Food System and contributes to Food Justice in Ghana. Future scaling will depend on consistent policies and efforts to respond to challenges and opportunities along the value chain for sustainability. Impact pathways of theories of change and scaling helped us understand the scaling progress of OFSP in Ghana.
Verifying a novel bile cytology scoring system
Authors: Hayakawa Chie , Hoshikawa Masahiro , Imura Johji , Ueno Takahiko , Koike Junki 
Published: May 2024

AbstractBackgroundThe scoring system for bile cytology (SSBC) aims to improve bile cytology diagnostic accuracy. Here, the practicality of SSBC was verified by multiple cytotechnologists.MethodsBile cytological specimens were evaluated by 24 cytotechnologists using SSBC. The samples were assessed before using the SSBC (first‐time assessment) according to three categories: benign, indeterminate, and malignant. A first scoring evaluation (FSE) was then performed using SSBC; each item in the scoring system was classified as present or absent. After distributing an instruction sheet with diagnostic criteria, a second scoring evaluation (SSE) was performed using SSBC. Each method was evaluated using diagnostic accuracy and interobserver and intraobserver agreement.ResultsSeveral samples were assessed as indeterminate in the first‐time assessment. Although the specificity of the SSE improved, the sensitivity and accuracy decreased compared with those of the FSE. The overall interobserver agreement was fair for all parameters, including abnormal chromatin, irregular internuclear distances, irregularly overlapped nuclei, irregular cluster margins, and final evaluation in the FSE and SSE. The final evaluation by histological type exhibited slight agreement for well‐differentiated tubular adenocarcinoma and almost perfect agreement for poorly differentiated tubular adenocarcinoma in the FSE and SSE. For moderately differentiated tubular adenocarcinoma, agreement was moderate in the FSE and fair in the SSE. For cholangitis, a slight agreement was observed in the FSE, which improved to fair in the SSE.ConclusionsAlthough the SSBC is expected to improve specificity, there exists ambiguity regarding SSBC criteria and interindividual assessment differences. Therefore, the objective assessment method should be revised.
Characteristics and drivers of vegetation productivity sensitivity to increasing CO2 at Northern Middle and High Latitudes
Authors: Chai Yuanfang , Hu Yong 
Published: May 2024

AbstractUnderstanding and accurately predicting how the sensitivity of terrestrial vegetation productivity to rising atmospheric CO2 concentration (β) is crucial for assessing carbon sink dynamics. However, the temporal characteristics and driving mechanisms of β remain uncertain. Here, observational and CMIP6 modeling evidence suggest a decreasing trend in β at the Northern Middle and High Latitudes during the historical period of 1982–2015 (−0.082 ± 0.005% 100 ppm−1 year−1). This decreasing trend is projected to persist until the end of the 21st century (−0.082 ± 0.005% 100 ppm−1 year−1 under SSP370 and −0.166 ± 0.006% 100 ppm−1 year−1 under SSP585). The declining β indicates a weakening capacity of vegetation to mitigate warming climates, posing challenges for achieving the temperature goals of the Paris Agreement. The rise in vapor pressure deficit (VPD), that triggers stomata closure and weakens photosynthesis, is considered as the dominated factor contributing to the historical and future decline in β, accounting for 62.3%–75.2% of the effect. Nutrient availability and water availability contribute 15.7%–21.4% and 8.5%–16.3%, respectively. These findings underscore the significant role of VPD in shaping terrestrial carbon sink dynamics, an aspect that is currently insufficiently considered in many climate and ecological models.
Enhancing ecological success in Yangtze River channel construction: A numerical modelling approach
Authors: Li Pengcheng , Li Yike , Yang Yang , Wang Qianqian , Yao Weiwei 
Published: May 2024

AbstractChannel constructions significantly impact river hydrodynamics, subsequently influencing river ecosystems. To mitigate the negative influence of channel construction and protect fish habitat, it is essential to evaluate fish habitat suitability through the integration of hydrodynamic and habitat models. This study models channel constructions on both the left and right riverbanks to evaluate habitat suitability for Four Major Chinese Carps and the Chinese sturgeon. Initially, flow velocity, water depth and grain size are simulated, followed by an assessment of habitat conditions using the Habitat Suitability Index (HSI) for three distinct construction strategies. Results reveal that constructing channels on the left bank mitigates adverse effects on fish habitat, while constructions on the right bank and both riverbanks lead to habitat degradation. Long‐term effects on riverbed elevation and fish habitat suitability post‐construction were also investigated. Notably, the Four Major Chinese Carps consistently demonstrate greater suitability for the studied river, regardless of flow rate or construction strategies, in comparison to the Chinese sturgeon. These findings underscore diverse responses to channel construction, providing valuable insights for identifying critical habitat areas for endemic fish conservation. This research presents a robust framework for assessing fish ecology in river systems, offering support for conservation decision‐makers.
Update on Endogenous HNO Production: An Exploration of Unanswered Questions and Challenges
Authors: Vargas Paola , Doctorovich Fabio A. , Suarez Sebastian A. 
Published: May 2024

AbstractThis review consolidates the evidence supporting endogenous HNO generation through enzymatic and non‐enzymatic pathways, emphasizing advancements in real‐time HNO sensing within living systems. Azanone (nitroxyl, HNO) is the one‐electron‐reduced congener of nitric oxide (NO•) and shares various biological actions. HNO exhibits unique properties, including positive inotropic and lusitropic effects, along with resistance to scavenging by reactive oxygen species (ROS), particularly superoxide. Research on HNO has intensified over the last two decades, focusing on its reactivity and the prospect of endogenous formation due to its potential significance. The high reactivity of HNO arises from reactions with biologically relevant species such as oxygen, NO•, and thiols, as well as self‐dimerization. Detecting and quantifying HNO has posed challenges, initially relying on nitrous oxide (N2O) detection, a byproduct of dimerization. Recent advancements, including fluorescent probes and a specific electrochemical nanomolar‐level sensor, have facilitated direct detection, enhancing understanding of HNO reactivity and formation.
Synthesis and Aerobic Oxidation of Perfluoroalkyl d10 Metal Complexes Supported by 2,7‐Dimethyl‐1,8‐Naphthyridine
Authors: Moradi Hanieh , Govindarajan R. , Nguyen Huy Gia , Deolka Shubham , Dinh Hoan M. , Khaskin Eugene , Fayzullin Robert R. , Vasylevskyi Serhii , Khusnutdinova Julia R. 
Published: May 2024

AbstractThe coordination chemistry of 2,7‐dimethyl‐1,8‐naphthyridine has been explored with perfluoroalkyl d10 metals, CuI, ZnII, and AgI. This ligand was shown to form dicoordinate CuI and AgI mono‐perfluoroalkyl complexes where naphthyridine coordinates with only one N‐donor, while bidentate coordination with both N‐atoms was observed in Zn bis(perfluoroalkyl) complexes forming a strained four‐membered chelate ring. Copper complexes undergo facile oxidation in the presence of air or excess O2 to give tetracoordinate CuII complexes coordinated to perfluorocarboxylates formed by oxygenation of the metal‐adjacent α‐CF2 position of the corresponding perfluoroalkyl ligands. Another type of product formed by the oxidation of perfluoroethylcopper(I) complexes in the presence of substoichiometric O2 are binuclear CuI⋅⋅⋅CuI complexes with two perfluorocarboxylate ligands. In the presence of an external substrate, alkene, O‐atom transfer was observed to give oxygenated products, resembling the recently reported O‐transfer reactivity of naphthyridine‐supported Ni long‐chain perfluoroalkyl complexes.