bluuebunny/crossref_metadata_2025_split huggingface dataset:
The treatment of night eating: the patient's perspective
Authors: Goncalves Marcus D. , Moore Reneé H. , Stunkard Albert J. , Allison Kelly C. 
Published: April 2009

AbstractNight eating (NE) is recognizable and treatable. The purpose of this study was to assess patients' satisfaction with their doctors' treatment of NE and to compare it to that of treatment of a control condition, ‘headache’. An Internet‐based questionnaire assessed patients' (n = 103) perceptions of their doctors' knowledge and treatment of NE versus headache, levels of treatment satisfaction and demographic and descriptive aspects of their NE. Most patients (61%) were ‘not at all satisfied’ with their doctors' treatment of NE. Patients reported low recognition and high levels of dismissal of NE by their doctors. Of patients who had been treated for both NE and headache by the same doctor, 29% were ‘not at all satisfied’ with their treatment of headache compared to 76% ‘not at all satisfied’ with their treatment of NE (p = 0.02). In conclusion, most patients reported that their doctors did not identify or treat NE, which led to dissatisfaction with their care. Copyright © 2009 John Wiley & Sons, Ltd and Eating Disorders Association.
Economic model‐based radio resource management with QoS guarantees in the CDMA uplink
Authors: Pei Xuebing , Zhu Guangxi , Wang Qingping , Qu Daiming , Liu Jian 
Published: April 2009

AbstractIn this paper, radio resource management based on economic model is investigated in detail in the CDMA uplink. A novel economic model is proposed to allocate the radio resources with QoS guarantees in an efficient manner. Firstly, we deduce the resources usage constraint that takes the multi‐cell interference power into account in the CDMA uplink. Then a novel utility function is designed to evaluate the total network revenue from the limited radio resources, it considers the factors of both network resources and user preferences such as data rate or signal quality. Under the resources usage constraint of considering multi‐cell interference, the radio resource allocation is formulated into an optimisation problem with the objective function of maximising the total network revenue, which is solved to get the optimal transmission rate for each user while guaranteeing the level of signal quality. Numerical results show that approximately more than 20% number of users and another 5% network revenue are achieved according to our resource allocation algorithm compared with traditional ones; meanwhile, signal quality of each mobile user is guaranteed effectively. Copyright © 2009 John Wiley & Sons, Ltd.
New estimates of the demand for physical and mental health treatment
Authors: Meyerhoefer Chad D. , Zuvekas Samuel H. 
Published: April 2009

AbstractConsumers' price responsiveness is central to US health‐care reform proposals, but the best available estimates are now more than 25 years old. We estimate health‐care demands by calculating expected end‐of‐year prices and incorporating them into a zero‐inflated ordered probit model applied to several overlapping panels of data from 1996 to 2003. Results from our correlated random effects specification indicate that the price responsiveness of ambulatory mental health treatment has decreased substantially and is now slightly lower than physical health treatment. This suggests that concerns over moral hazard alone do not warrant less generous coverage for mental health. However, prescription drug demand is more price elastic. Published in 2009 by John Wiley & Sons, Ltd.
Supplemental health insurance and equality of access in Belgium
Authors: Schokkaert Erik , Van Ourti Tom , De Graeve Diana , Lecluyse Ann , Van de Voorde Carine 
Published: April 2009

AbstractThe effects of supplemental health insurance on health‐care consumption crucially depend on specific institutional features of the health‐care system. We analyse the situation in Belgium, a country with a very broad coverage in compulsory social health insurance and where supplemental insurance mainly refers to extra‐billing in hospitals. Within this institutional background, we find only weak evidence of adverse selection in the coverage of supplemental health insurance. We find much stronger effects of socio‐economic background. We estimate a bivariate probit model and cannot reject the assumption of exogeneity of insurance availability for the explanation of health‐care use. A count model for hospital care shows that supplemental insurance has no significant effect on the number of spells, but a negative effect on the number of nights per spell. We comment on the implications of our findings for equality of access to health care in Belgium. Copyright © 2009 John Wiley & Sons, Ltd.
Synthesis of 5,7‐Dihydrodibenzo[b,f][1,7]naphthyridine‐6,12‐dione, an Unexpected Isolate from Isatis tintoria
Authors: Riepl Herbert M. , Kellermann Melanie 
Published: April 2009

Abstractmagnified imageThe dye plant Isatis tinctoria yields a number of heterocyclic compounds with interesting anti‐inflammatory and cytotoxic properties, formed mainly in an unknown manner by post‐harvest treatment. A synthesis of the incidently isolated 5,7‐dihydrodibenzo[b,f][1,7]naphthyridine‐6,12‐dione (4a) is presented. Starting from different 1,2‐diarylhydrazines, adducts 11 with acetylenedicarboxylates (=but‐2‐ynedioates) are thermally treated (Scheme). In a Fischer‐type rearrangement, 3‐(arylamino)quinolinecarboxylic acids 9 are obtained, which can be cyclized under Friedel–Crafts conditions to yield a number of analoga 4 of the title compound.
Molecular Rearrangement of 9b‐Hydroxy‐1H‐imidazo[4,5‐c]quinoline‐2,4‐diones – A Convenient Pathway to Spiro‐Linked Imidazolidine–Oxindole Derivatives
Authors: Klásek Antonín , Lyčka Antonín , Mikšík Ivan , Růžička Aleš 
Published: April 2009

Abstractmagnified imageThe 1‐substituted 3‐alkyl/aryl‐3‐aminoquinoline‐2,4(1H,3H)‐diones 1 react with alkyl/aryl isocyanates to give novel 3‐alkyl/aryl‐3‐ureidoquinoline‐2,4(1H,3H)‐diones (=N‐(3‐alkyl/aryl‐1,2,3,4‐tetrahydro‐2,4‐dioxoquinolin‐3‐yl)ureas) 2 and/or 3a‐alkyl/aryl‐3,3a,5,9b‐tetrahydro‐9b‐hydroxy‐1H‐imidazo[4,5‐c]quinoline‐2,4‐diones 3 in high yields. Compounds 2 and 3 rearrange by boiling in AcOH or concentrated HCl solution to give three different types of spiro[imidazolidine‐4,3′‐[3H]indole]‐2,2′(1′H)‐diones, i.e., 10, 11, and 12, depending on the kind of substituents at C(3) and C(3a), respectively. All compounds were characterized by 1H‐ and 13C‐NMR and IR spectroscopy as well as by atmospheric‐pressure chemical‐ionization (APCI) mass spectra. The structures of compounds 11c and 12Al were investigated by single‐crystal X‐ray diffraction analysis.
Fused Isothiazole S‐Oxide Systems from Cycloaddition Reactions of N‐Benzylisothiazol‐3‐amine 1‐Oxide
Authors: Clerici Francesca , Casoni Alessandro , Contini Alessandro , Gelmi Maria L. , Pellegrino Sara 
Published: April 2009

Abstractmagnified imageThe racemic N‐benzylisothiazol‐3‐amine 1‐oxide (2) was demonstrated to be an efficient partner in Diels–Alder reactions (Schemes 2–4) and a good dipolarophile in 1,3‐dipolar cycloaddition reactions with nitrile oxides (Scheme 5). Polycyclic isothiazole S‐oxides with different substitution patterns were obtained from 2 in good yield and in a fully regioselective way. Improved diastereoselection was observed performing the Diels–Alder or 1,3‐dipolar cycloaddition reactions in H2O.
Diterpenoid and Norditerpenoid Alkaloids from the Roots of Aconitum yesoense var. macroyesoense
Authors: Wada Koji , Kawahara Norio 
Published: April 2009

Abstractmagnified imageA new diterpenoid alkaloid, macroyesoenline (1), and a new norditerpenoid alkaloid, 9‐hydroxyvirescenine (2), have been isolated from the roots of Aconitum yesoense var. macroyesoense. Their structures were elucidated on the basis of spectral data (1D‐ and 2D‐NMR experiments) and mass spectrometry. The known norditerpenoid and diterpenoid alkaloids delphinifoline (3) and cochlearenine (13) were isolated for the first time from this plant.
Photocleavage of Peptides and Oligodeoxynucleotides Carrying 2‐Nitrobenzyl Groups
Authors: Ramos Roger , Manning Brendan , Aviñó Anna , Gargallo Raimundo , Eritja Ramon 
Published: April 2009

Abstractmagnified imagePeptides and oligodeoxynucleotides containing photolabile 2‐nitrobenzyl groups as mid‐sequences were prepared. Photocleavage of aqueous solutions of these compounds neared completion within 30 min to a few hours depending on the photolabile group used. A photolabile group was introduced in the loop of an intramolecular oligodeoxynucleotide hairpin. Melting curves of the hairpin with and without the complementary oligodeoxynucleotide showed a preference for the intramolecular hairpin form, but an intermolecular duplex was observed after photolysis. These results open the possibility of using photolabile DNA hairpins for the fabrication of patterned surfaces.
Ecdysteroids from Silene viridiflora
Authors: Simon András , Tóth Noémi , Tóth Gábor , Kele Zoltán , Groska Judit , Báthori Mária 
Published: April 2009

Abstractmagnified imageTwo new ecdysteroid acetonide derivatives, 5α‐2‐deoxy‐20‐hydroxyecdysone 20,22‐acetonide (6) and makisterone C 2,3;20,22‐diacetonide (8), were isolated from the dried herb of Silene viridiflora. The already known 5β‐2‐deoxy‐20‐hydroxyecdysone 20,22‐acetonide (7) is additionally reported here as a new constituent of S. viridiflora. Five earlier described S. viridiflora ecdysteroids, integristerone A (1), 5,20,26‐trihydroxyecdysone (26‐hydroxypolipodine B; 2), 20,26‐dihydroxyecdysone (3), 2‐deoxy‐20‐hydroxyecdysone (4), 2‐deoxyintegristerone A (5), are also included because of their improved characterization. The structures were established via spectroscopic analyses, including one‐ and two‐dimensional NMR and mass spectrometry.
New C20‐Diterpenoid Alkaloids from Delphinium anthriscifolium var. savatieri
Authors: Liu Xiao‐Yu , Chen Qiao‐Hong , Wang Feng‐Peng 
Published: April 2009

Abstractmagnified imageFive new vakognavine‐type C20‐diterpenoid alkaloids, anthriscifolmines D–H (1–5, resp.), were isolated from the whole herb of Delphinium anthriscifolium var. savatieri. The structures of these new alkaloids were determined by spectroscopic techniques, including HR‐ESI‐MS, 1D‐, and 2D‐NMR experiments.
Scalarane Sesterterpenes from the Chinese Sponge Phyllospongia foliascens
Authors: Zhang Hong‐Jun , Tang Hai‐Feng , Yi Yang‐Hua , Lin Hou‐Wen 
Published: April 2009

Abstractmagnified imageThree new scalarane sesterterpenes, phyllofolactone L (1), phyllofenone D (2) and phyllofenone E (3), were isolated from the acetone extract of the South China Sea sponge Phyllospongia foliascens. Their structures were elucidated on the basis of spectroscopic analysis. Phyllofenone D (2) was cytotoxic against the P388 leukemia cell line with an IC50 value of 6.5 μg/ml.
Selectivity Enhancement for the Jacobsen–Katsuki Epoxidation in Fluorinated Solvents
Authors: Havare Nizam , Plattner Dietmar A. 
Published: April 2009

Abstractmagnified imageIn 1,1,1,2,3,4,4,5,5,5‐Decafluoropentane using 2‐phenylpyridine N‐oxide as donor ligand, the enantioselectivity of the Jacobsen–Katsuki epoxidation is improved up to 10% ee as compared to established protocols.
FAK overexpression and p53 mutations are highly correlated in human breast cancer
Authors: Golubovskaya Vita M. , Conway‐Dorsey Kathleen , Edmiston Sharon N. , Tse Chiu‐Kit , Lark Amy A. , Livasy Chad A. , Moore Dominic , Millikan Robert C. , Cance William G. 
Published: April 2009

AbstractFocal adhesion kinase (FAK) is overexpressed in a number of tumors, including breast cancer. Another marker of breast cancer tumorigenesis is the tumor suppressor gene p53 that is frequently mutated in breast cancer. In the present study, our aim was to find a correlation between FAK overexpression, p53 expression and mutation status in a population‐based series of invasive breast cancer tumors from the Carolina Breast Cancer Study. Immunohistochemical analyses of 622 breast cancer tumors revealed that expression of FAK and p53 were highly correlated (p = 0.0002) and FAK positive tumors were 1.8 times more likely to be p53 positive compared to FAK negative tumors [odds ratio (OR) = 1.8; 95% Confidence Interval (CI) 1.2–2.8, adjusted for age, race and stage at diagnosis]. Tumors positive for p53 expression showed higher intensity of FAK staining (p < 0.0001) and higher percent of FAK positive staining (p < 0.0005). From the same study, we evaluated 596 breast tumors for mutations in the p53 gene, using single strand conformational polymorphism and sequencing. Statistical analyses were performed to determine the correlation between p53 mutation status and FAK expression in these tumors. We found that FAK expression and p53 mutation were positively correlated (p < 0.0001) and FAK positive tumors were 2.5 times more likely to be p53 mutation positive compared to FAK negative tumors [adjusted OR = 2.5, 95% CI 1.6–3.9]. This is the first analysis demonstrating a high correlation between FAK expression and p53 mutations in a population‐based series of breast tumors. © 2009 UICC
Single nucleotide polymorphism of rs430397 in the fifth intron of GRP78 gene and clinical relevance of primary hepatocellular carcinoma in Han Chinese: Risk and prognosis
Authors: Zhu Xiao , Chen Min‐Shan , Tian Lin‐Wei , Li Dong‐Pei , Xu Pei‐Lin , Lin Marie C. M. , Xie Dan , Kung Hsiang‐Fu 
Published: April 2009

AbstractLarge number of data showed that allele variants in certain genes are markers for hepatocellular carcinoma (HCC). GRP78 is a stress‐associated protein which is a central regulator of endoplasmic reticulum homeostasis due to its multiple functional roles in the folding, maturation and transport of proteins. A case‐control study was conducted on 576 HCC patients, and 539 age‐ and gender‐matched healthy subjects to examine whether rs430397 polymorphism in the fifth intron of GRP78 gene is associated with the development and prognosis of HCC. Polymorphism in rs430397 was analyzed by resequencing and TaqMan real‐time PCR. Allele A, genotype AA and combined genotypes (AG+AA) displayed significantly increased risk for HCC (OR = 1.48, 95%CI = 1.07–1.79, p = 0.010; OR = 2.25, 95%CI= 1.08–3.38, p = 0.019; and OR = 1.50, 95%CI = 1.09–1.85, p = 0.012, respectively). Genotypes AA and AG were mainly associated with HBV‐related HCC (85.8%; p < 0.00001 versus HBV noncarriers with HCC) and cirrhosis‐related HCC (90%; p = 0.011 versus noncirrhosis HCC). Patients carrying the AA genotype had a shorter survival time (median 23.0 months in all cases; median 21.0 months in the cases carrying HBsAg). Like HBV and cirrhosis, the rs430397 is an independent prognostic factor influencing the survival of HCC. In conclusion, allele A and genotypes AA and AG of rs430397 may represent high risk and poor prognosis for HCC. © 2009 UICC
Photodynamic therapy with 5‐aminolevulinic acid and diamino acid derivatives of protoporphyrin IX reduces papillomas in mice without eliminating transformation into squamous cell carcinoma of the skin
Authors: Kwitniewski Mateusz , Jankowski Dawid , Jaskiewicz Kazimierz , Dziadziuszko Halina , Juzeniene Asta , Moan Johan , Ma Li‐Wei , Peksa Rafal , Kunikowska Danuta , Graczyk Alfreda , Kwasny Miroslaw , Kaliszewski Miron , Glosnicka Renata 
Published: April 2009

AbstractPhotodynamic therapy (PDT) is used to treat malignant and nonmalignant diseases. It is also used for cosmetological skin treatment. PDT is generally considered to have a low risk of carcinogenicity. However, instances of nonmalignant human tumors turning malignant have been linked to PDT. In this study, we used 5‐aminolevulinic (ALA) acid and 3 water soluble photosensitizers‐PP(Arg)2, PP(Ser)2Arg2, PP(Ala)2Arg2, all diamino acid derivatives of protoporphyrin IX‐to treat benign papillomas in FVB/N mice induced by 7,12‐dimethylbenz(a)anthracene (DMBA)‐12‐O‐tetradecanoyl‐phorbol‐13‐acetate (TPA). Of these drugs, ALA and PP(Arg)2 were found the most efficient. PDT reduced the number of papillomas, but with increasing effectiveness of the drugs, the risk of malignant transformation of the papillomas into squamous cell carcinomas increased. The underlying mechanisms are not clear and further investigations are needed. © 2009 UICC
TOB suppresses breast cancer tumorigenesis
Authors: O'Malley Sean , Su Hua , Zhang Tao , Ng Crystal , Ge Hong , Tang Careen K. 
Published: April 2009

AbstractTransducer of ErbB‐2 (TOB) is a member of the TOB/Btg gene family. A role for TOB in the suppression of human tumorigenesis has been proposed, based on the observations that TOB‐knockout mice spontaneously form tumors and TOB expression is lost in human lung and thyroid cancers. However, the role of TOB in human breast cancer remains unknown. To evaluate the this role, we screened a panel of breast cancer cell lines for TOB expression levels and found that they are inversely correlated with the tumorigenicity and metastatic potential of the cell lines. In addition, we demonstrated for the first time that TOB expression is inversely correlated with breast cancer progression in clinical specimens. These results strongly indicate that the loss of TOB expression plays a role in breast cancer progression. We have also provided the first evidence that TOB functions as a tumor suppressor in breast cancer MCF‐7 cells, using gain‐of‐function and loss‐of‐function approaches to manipulate TOB expression. Cell‐cycle analysis further revealed that TOB can prolong the G1‐S phase transition by inducing arrest at G1‐S phase. Moreover, upregulation of the cyclin‐dependent kinase inhibitor p27 and downregulation of the antiapoptotic proteins Bcl‐2 and Bcl‐XL were observed in MCF7/TOB transfectants. Conversely, opposite results were observed in shRNA‐TOB transfectants. Furthermore, decreased activity of Erk2, AKT, CrkL, PDK1, and Smads were observed in TOB‐overexpressing cells. Taken together, these data provide evidence that TOB can function as a tumor suppressor in breast cancer through modulation and regulation of multiple signaling pathways. © 2009 UICC
Down‐regulation of the transcriptional mediator subunit Med1 contributes to the loss of expression of metastasis‐associated dapk1 in human cancers and cancer cells
Authors: Gade Padmaja , Singh Ashish K. , Roy Sanjit K. , Reddy Sekhar P. , Kalvakolanu Dhananjaya V. 
Published: April 2009

AbstractDAPK1, a ca+2/calmodulin regulated serine/threonine kinase, is a major tumor suppressor, whose expression is lost in multiple tumor types. However, the mechanisms contributing to it are unclear. We have recently shown that CCAAT/Enhancer binding protein‐β (C/EBP‐β) is required for the basal and interferon γ (IFN‐γ)‐induced expression of dapk1 in many cell types. C/EBP‐β interacts with the transcriptional Mediator, a multisubunit complex that couples enhancer bound transcription factors to the basal transcriptional machinery in an IFN‐γ dependent manner for regulating dapk1 expression. Specifically, the Med1 (TRAP220/PBP/DRIP220/CRSP220) subunit associates with the enhancer bound C/EBP‐β at the CRE/ATF site of dapk1 in an IFN‐γ dependent manner for stimulating gene expression. Therefore, we investigated if the mechanism responsible for the loss of dapk1 expression in human cancers involves a failure to recruit C/EBP‐β and/or Med1 to the dapk1 promoter. We compared the relative occupancy of these factors at the dapk1 promoter at CRE/ATF sites in normal and cancer cell lines. A significantly lower binding of these factors to the CRE/ATF site of dapk1 promoter occurred in human cancer cell lines than in normal cells. We show that loss of Med1 expression correlates with a corresponding loss of dapk1 expression in a number of primary human lung carcinomas. Med1 levels were significantly lower in cancer cell lines than in normal controls. Importantly, we show that restoration of Med1 induces the expression of dapk1 in these cancer cells and also attenuates their metastatic potential in vivo. Our studies reveal a critical parameter limiting dapk1 expression in cancer cell lines. © 2009 UICC
Parity and age at first childbirth in relation to the risk of different breast cancer subgroups
Authors: Butt Salma , Borgquist Signe , Anagnostaki Lola , Landberg Göran , Manjer Jonas 
Published: April 2009

AbstractThe aim of the present study was to examine parity and age at first childbirth, in relation to the risk of specific breast cancer subgroups. A prospective cohort, The Malmö Diet and Cancer Study, including 17,035 women were followed with linkage to Swedish Cancer Registry until December 31, 2004. A total of 622 incident breast cancers were diagnosed during follow‐up and were evaluated regarding invasiveness, tumour size, axillary lymph node status, Nottingham grade, tumour proliferation (Ki67), HER2, cyclin D1 and p27. The tumours were also examined for WHO type and hormone receptor status. Nulliparity was associated with an overall increased risk of breast cancer, although not statistically significant (the relative risk was 1.39 with a 95% confidence interval of 0.92–2.08). Nulliparity was also associated with large tumours (>20 mm) (1.89: 0.91–3.91), high Ki67 levels (1.95: 0.93–4.10), high cyclin D1 levels (2.15: 0.88–5.27), grade III (2.93: 1.29–6.64) and HER2 positive tumours (3.24: 1.02–10.25). High parity was not statistically significantly associated with any specific breast cancer subgroup. Older age at first childbirth (>30) was associated with a slightly increased risk of breast cancer (1.39: 0.94–2.07). There was a statistically significant association between late first childbirth and lobular type (2.51: 1.01–6.28), grade III tumours (2.67: 1.19–6.02), high levels of cyclin D1 (2.69: 1.18–6.12) and low levels of p27 (2.23: 1.15–4.35). We conclude that nulliparity and late first childbirth are associated with relatively more aggressive breast cancer subgroups. © 2009 UICC
Artemisinin dimer anticancer activity correlates with heme‐catalyzed reactive oxygen species generation and endoplasmic reticulum stress induction
Authors: Stockwin Luke H. , Han Bingnan , Yu Sherry X. , Hollingshead Melinda G. , ElSohly Mahmoud A. , Gul Waseem , Slade Desmond , Galal Ahmed M. , Newton Dianne L. 
Published: April 2009

AbstractAnalogs of the malaria therapeutic, artemisinin, possess in vitro and in vivo anticancer activity. In this study, two dimeric artemisinins (NSC724910 and 735847) were studied to determine their mechanism of action. Dimers were >1,000 fold more active than monomer and treatment was associated with increased reactive oxygen species (ROS) and apoptosis induction. Dimer activity was inhibited by the antioxidant L‐NAC, the iron chelator desferroxamine and exogenous hemin. Similarly, induction of heme oxygenase (HMOX) with CoPPIX inhibited activity, whereas inhibition of HMOX with SnPPIX enhanced it. These results emphasize the importance of iron, heme and ROS in activity. Microarray analysis of dimer treated cells identified DNA damage, iron/heme and cysteine/methionine metabolism, antioxidant response, and endoplasmic reticulum (ER) stress as affected pathways. Detection of an ER‐stress response was relevant because in malaria, artemisinin inhibits pfATP6, the plasmodium orthologue of mammalian sarcoplasmic/endoplasmic reticulum Ca2+‐ATPases (SERCA). A comparative study of NSC735847 with thapsigargin, a specific SERCA inhibitor and ER‐stress inducer showed similar behavior in terms of transcriptomic changes, induction of endogenous SERCA and ER calcium mobilization. However, thapsigargin had little effect on ROS production, modulated different ER‐stress proteins and had greater potency against purified SERCA1. Furthermore, an inactive derivative of NSC735847 that lacked the endoperoxide had identical inhibitory activity against purified SERCA1, suggesting that direct inhibition of SERCA has little inference on overall cytotoxicity. In summary, these data implicate indirect ER‐stress induction as a central mechanism of artemisinin dimer activity. © 2009 UICC