bluuebunny/crossref_metadata_2025_split huggingface dataset:
Routine outcome monitoring in the Netherlands: practical experiences with a web‐based strategy for the assessment of treatment outcome in clinical practice
Authors: de Beurs E. , den Hollander‐Gijsman M. E. , van Rood Y. R. , van der Wee N. J. A. , Giltay E. J. , van Noorden M. S. , van der Lem R. , van Fenema E. , Zitman F. G. 
Published: March 2010

AbstractRoutine outcome monitoring (ROM) is a method devised to systematically collect data on the effectiveness of treatments in everyday clinical practice. ROM involves documenting the outcome of treatments through repeated assessments. Assistants are employed who perform a baseline assessment comprising a standardized diagnostic interview, administration of rating scales and completion of several self‐report measures by the patient. At fixed time intervals, assessments are repeated. Dedicated Web‐based software has been developed to assist in this task. ROM informs therapists and patients on the severity of the complaints at intake, and the waxing and waning of symptoms over the course of treatment. Researchers can use ROM for effectiveness research, and managers can use it for benchmarking. The use of ROM for research is illustrated by presenting data on the diagnostic status of patients participating in ROM and data on treatment outcome of a subgroup of patients (with panic disorder) in our database. The results show that implementation of ROM is feasible, and after some initial reservations, most therapists now consider ROM to be a necessary and important adjunct to the clinical treatment. In addition, ROM furthers research as the data can be used to study the phenomenology of psychiatric disorders and the outcome of treatments delivered in everyday practice. Copyright © 2010 John Wiley & Sons, Ltd.Key Practitioner Message:• A form of tracking the progress of treatment through routine outcome monitoring (ROM) is described.• Implementation of ROM appears feasible and can be carried out in large institutions as well as smaller practices.• Providing feedback about outcome in an appealing format is highly valued by both therapists and patients.• ROM data enable investigation of the effectiveness of treatments in everyday clinical practice.
An innovative model to promote CSR among SMEs operating in industrial clusters: evidence from an EU project
Authors: Battaglia Massimo , Bianchi Lara , Frey Marco , Iraldo Fabio 
Published: March 2010

AbstractThis paper presents the findings of our EU co‐funded project, an idea developed to better understand the opportunities to formalize corporate social responsibility (CSR) practices for small and medium enterprises (SMEs) in a clustered system. Small companies often have to compete in a global market; for this reason, cooperation among SMEs, and with local stakeholders and intermediary institutions, might be facilitated by a collective answer to new market requests. Cooperation and social capital are key elements to facilitate trust amongst involved local actors. Moreover, they can also play a key role in the formalization of CSR policies and practices for small companies. In our project, we aimed at identifying and understanding the role of the ‘intermediary institutions’ (such as trade unions, local authorities, business consortia) in the cluster. Throughout the paper, we focus on the analysis of three industrial clusters in Tuscany (Italy). Copyright © 2010 John Wiley & Sons, Ltd and ERP Environment.
Authenticated route optimization scheme for network mobility (NEMO) support in heterogeneous networks
Authors: Koo Jung‐Doo , Oh Seong‐Hoon , Lee Dong‐Chun 
Published: March 2010

AbstractFor the efficient communications between mobile or fixed hosts in mobile networks, the route optimization and its security are indispensable. So, the Internet Engineering Task Force introduced a NEMO basic support protocol in 2005. However, this protocol does not provide a strong security between hosts and especially in nested‐mobile network it can incur a pinball routing problem. And the previous Proxy Binding Update (PUB) protocol has an advantage that can prove the ownership of address of a host using Multi‐key Cryptographically Generated Address (MCGA) which can alleviate a neighbor bombing attack. However, a Mobile Network Node (MNN) belonging to the mobile network which can have low power or limited computing capability may be require burdened costs such as signification and verification of messages. Also, the PUB protocol does not provide the secure message communication architecture between the MNN and its Mobile Router (MR). In this paper we propose a CGA‐based Authentication Route Optimization scheme (CARO) in mobile hotspots with heterogeneous networks. The proposed CARO protocol satisfies two problems using IPsec Encapsulating Security Payload (ESP) tunnel, a secret mobile group key, and the CGA. And we also do not require the considerable computing costs to the MNN or a Correspondent Node. In performance analysis, we prove more secure and efficient protocols than the previous protocols using the defense of various attacks and the result of computational cost, etc. Copyright © 2010 John Wiley & Sons, Ltd.
Kinetics of trichloroethylene and toluene toxicity to Pseudomonas putida F1
Authors: Singh Rajveer , Olson Mira Stone 
Published: March 2010

Abstract
The goal of the present study was to elucidate the distribution of viable bacteria in chemical gradients and to evaluate the toxic effect of high concentrations of contaminants on contaminant-degrading bacteria under prolonged exposure. Accumulations of viable Pseudomonas putida F1 (P. putida F1) cells were observed surrounding trichloroethylene (TCE)-containing plugs. Results from this work indicate that P. putida F1 immediately adjacent to a TCE source become nonviable, whereas cells accumulating farther away use chemotaxis to migrate toward regions with optimal chemical concentrations in the form of concentrated bacterial bands. A method was developed to test the toxicity of model contaminant stressors, TCE and toluene, to P. putida F1; data obtained from toxicity experiments were fit to linear and exponential bacterial viability-decay models. Toxicity of TCE to P. putida F1 was best described with an exponential viability-decay model, with a viability-decay constant kTCE = 0.025 h−4.95 (r2 = 0.965). Toluene toxicity showed a marginally better fit to the linear viability-decay model (r2 = 0.976), with a viability-decay constant ktoluene = 0.208 h−1. Best-fit model parameters obtained for both TCE and toluene were used to predict bacterial viability in toxicity experiments with higher contaminant concentrations and matched well with experimental data. Results from the present study can be used to predict bacterial accumulation and viability near nonaqueous-phase liquid (NAPL) sources in groundwater and may be helpful in designing bioremediation strategies for sites contaminated with residual NAPLs. Environ. Toxicol. Chem. 2010;29:56–63. © 2009 SETAC
Toxicity of methyl tert butyl ether to soil invertebrates (springtails: Folsomia candida, Proisotoma minuta, and Onychiurus folsomi) and lettuce (Lactuca sativa)
Authors: Dodd Matthew , Addison Janet A. 
Published: March 2010

Abstract
Experiments were conducted to assess the toxicity of methyl tert butyl ether (MTBE) to three species of Collembola (Proisotoma minuta, Folsomia candida, and Onychiurus folsomi) and lettuce (Lactuca sativa L.) using an artificial Organization for Economic Cooperation and Development (OECD) soil and field-collected sandy loam and silt loam soil samples. Soil invertebrate tests were carried out in airtight vials to prevent volatilization of MTBE out of the test units and to allow for direct head-space sampling and gas chromatography-mass spectrometry (GC-MS) analysis for residual MTBE. The use of the airtight vial protocol proved to be very successful, in that the measured MTBE concentrations at the beginning of the experiments were within 95% of nominal concentrations. The test methods used in this study could be used to test the toxicity of other volatile organic compounds to Collembola. The soil invertebrates tested had inhibitory concentration (ICx) and lethal concentration (LCx) values that ranged from 242 to 844 mg MTBE/kg dry soil. When the three test species of Collembola were tested under identical conditions in the artificial OECD soil, O. folsomi was the most sensitive collembolan, with a median inhibitory concentration (IC50; reproduction) of 296 mg MTBE/kg dry soil. The most sensitive endpoint for lettuce was an IC50 for root length of 81 mg MTBE/kg dry soil after 5 d of germination in OECD soil. Data on the loss of MTBE from the three test soils over time indicated that MTBE was retained in the silt loam soil longer than in either the sandy loam or the artificial OECD soil. Environ. Toxicol. Chem. 2010;29:338–346. © 2009 SETAC
The toxic effects of benzyl glucosinolate and its hydrolysis product, the biofumigant benzyl isothiocyanate, to Folsomia fimetaria
Authors: Jensen John , Styrishave Bjarne , Gimsing Anne Louise , Bruun Hansen Hans Christian 
Published: March 2010

Abstract
Natural isothiocyanates (ITCs) are toxic to a range of pathogenic soil-living species, including nematodes and fungi, and can thus be used as natural fumigants called biofumigants. Natural isothiocyanates are hydrolysis products of glucosinolates (GSLs) released from plants after cell rupture. The study investigated the toxic effects of benzyl-GSL and its hydrolysis product benzyl-ITC on the springtail Folsomia fimetaria, a beneficial nontarget soil-dwelling micro-arthropod. The soil used was a sandy agricultural soil. Half-lives for benzyl-ITC in the soil depended on the initial soil concentration, ranging from 0.2 h for 67 nmol/g to 13.2 h for 3,351 nmol/g. For benzyl-ITC, the concentration resulting in 50% lethality (LC50) value for F. fimetaria adult mortality was 110 nmol/g (16.4 mg/kg) and the concentration resulting in 50% effect (EC50) value for juvenile production was 65 nmol/g (9.7 mg/kg). Benzyl-GSL proved to be less toxic and consequently an LC50 value for mortality could not be estimated for springtails exposed to benzyl-GSL. For reproduction, an EC50 value was estimated to approximately 690 nmol/g. The study indicates that natural soil concentrations of ITCs may be toxic to beneficial nontarget soil-dwelling arthropods such as springtails. Environ. Toxicol. Chem. 2010;29:359–364. © 2009 SETAC
Effects of pulp and paper mill effluent on fish: A temporal assessment of fish health across sampling cycles
Authors: Barrett Timothy J. , Lowell Richard B. , Tingley Maureen A. , Munkittrick Kelly R. 
Published: March 2010

Abstract
The Canadian environmental effects monitoring (EEM) program is a regulated, cyclical, industry-funded program designed to determine whether receiving water impacts exist when a mill is in compliance with its discharge limits. The results from three cycles of the fish monitoring program (1992 to 2004) are available from over 200 surveys of fish compared between sites located upstream and downstream of pulp and paper mill effluent outfalls. Previous meta-analyses have shown a national average response pattern across cycles characterized by an increase in endpoints measuring energy storage and growth and a decrease in a reproductive endpoint, consistent with a response of nutrient enrichment in combination with some form of metabolic disruption. Although the national average pattern of effects was temporally consistent, there was some variability in the magnitude of effects among cycles. Questions were raised as to whether the intercycle variability was due to changes in effluent quality or due, at least in part, to other factors. The present study compares responses over the first three cycles, and shows that the choice of sentinel species is likely to be a major contributing factor to the variability in observed effects. Subset analyses using studies from mills that used the same sentinel species across cycles reveal fairly uniform responses and little evidence of significant improvements in overall fish health from cycles one to three. However, a meta-analysis using 1991 data collected from 10 mills before the implementation of the EEM program and data from the same mills collected during cycles one to three of the program reveal significantly reduced effects on relative liver weight and potential improvements in other endpoints. Environ. Toxicol. Chem. 2010;29:440–452. © 2009 SETAC
Phage display as a novel screening tool for primary toxicological targets
Authors: Van Dorst Bieke , De Coen Wim , Blust Ronny , Robbens Johan 
Published: March 2010

Abstract
In the present study the use of phage display as a screening tool to determine primary toxicological targets was investigated. These primary toxicological targets are the targets in the cell with which a chemical compound initially interacts and that are responsible for consecutive (toxic) effects. Nickel was used as model compound for the present study. By selection of Ni-binding peptides out of a 12-mer peptide phage library, it was possible to identify primary toxicological targets of Ni (and other metals). The selected Ni-binding peptides showed similarities to important primary toxicological targets of Ni, such as the hydrogenase nickel incorporation protein (hypB) and the Mg/Ni/Co transporter (corA). This shows that phage display, which is already widely used in other research fields, also has potential in ecotoxicology, as a novel screening tool with which to determine primary toxicological targets of chemical compounds. Environ. Toxicol. Chem. 2010;29:250–255. © 2009 SETAC
Mercury and other metals in muscle and ovaries of goldeye (Hiodon alosoides)
Authors: Donald David B. , Sardella Gino D. 
Published: March 2010

Abstract
Concentrations of 24 trace metals were assessed in gravid ovaries and in muscle of female juvenile and adult female goldeye (Hiodon alosoides), a fish with both low annual growth (16 g/year as adults) and a long life span (maximum longevity of 30 years). It was hypothesized that adult fish with these life-history characteristics would maintain stable concentrations of metals in their tissues with higher levels of essential elements compared with those that are potentially toxic. As hypothesized, the concentration of most metals in muscle of adult female goldeye was similar at all ages, suggesting that uptake and excretion of metals was equal. Mercury was a notable exception. Total Hg concentrations in muscle of adults increased throughout life from a mean of 206 ng/g wet weight at age 8 to 809 ng/g at age 28, or by 26.2 ng/g/year. Concentrations of Hg were low in ovaries (mean 21.1 ng/g wet wt) compared to the mean for muscle, only 7% of the concentration in muscle. This was the lowest percent of muscle concentration of all 24 metals. Concentrations of Al, Ba, La, V, and Mn were significantly greater in muscle of juveniles and in ovaries than in muscle of adults. Concentrations of 13 metals were higher in ovaries relative to muscle, seven were similar, and four were depleted. Silver was enriched by over 50-fold in ovaries. Overall, the present study suggests that low concentrations of some metals in muscle of adult female goldeye, relative to concentrations in female juveniles and ovaries, may be maintained in part by transfer of metals to the external environment in eggs at spawning. Environ. Toxicol. Chem. 2010;29:373–379. © 2009 SETAC
A comparison of the copper sensitivity of six invertebrate species in ambient salt water of varying dissolved organic matter concentrations
Authors: Arnold W. Ray , Cotsifas Jeffrey S. , Ogle R. Scott , DePalma Sarah G. S. , Smith D. Scott 
Published: March 2010

Abstract
The copper sensitivity of four saltwater invertebrates (the mussel Mytilus galloprovincialis, the oyster Crassostrea virginica, the sand dollar Dendraster excentricus, and the sea urchin Strongylocentrotus purpuratus) was determined experimentally using chronic-estimator embryo-larval test procedures. The effect of sample dissolved organic matter (DOM) content on Cu bioavailability was determined for these species using commonly prescribed test procedures. Comparisons were made among these test results and test results reported previously for two other invertebrate species: the mussel Mytilus edulis and the copepod Eurytemora affinis. All six species exhibited a direct and significant relationship between the sample dissolved organic carbon (DOC; a surrogate measure of DOM) and either the dissolved Cu median lethal concentration (LC50) values or median effect concentration (EC50) values. This relationship is significant even when the DOM has different quality as evidenced by molecular fluorescence spectroscopy. Once normalized for the effects of DOM, the Cu sensitivity of these species from least to most sensitive were E. affinis &lt; D. excitricus &lt; C. virginica ≈ S. purpuratus ≈ M. edulis ≈ M. galloprovincialis. This ranking of species sensitivity differs from the saltwater species sensitivity distribution proposed in 2003 by the U.S. Environmental Protection Agency. These results support the need to account for factors that modify Cu bioavailability in future saltwater Cu criteria development efforts. More specifically, Cu saltwater species sensitivity distribution data will need to be normalized by factors affecting Cu bioavailability to assure that accurate and protective criteria are subsequently developed for saltwater species and their uses. Environ. Toxicol. Chem. 2010;29:311–319. © 2009 SETAC
Pulp and paper mill effluents induce distinct gene expression changes linked to androgenic and estrogenic responses in the fathead minnow (Pimephales promelas)
Authors: Werner Julieta , Ouellet Jacob D. , Cheng Caroline S. , Ju Young-Jun , Law R. David 
Published: March 2010

AbstractAlthough effluent treatment systems within pulp and paper mills remove many toxicants and improve wastewater quality, there is a need to understand and quantify the effectiveness of the treatment process. At a combined news and kraft pulp and paper mill in northwestern Ontario, Canada, fathead minnow (FHM) reproduction and physiology were examined before, during, and after a short-term (6-d) exposure to 10% (v/v) untreated kraft mill effluent (UTK), 25% (v/v) secondary treated kraft mill effluent (TK), and 100% (v/v) combined mill outfall (CMO). Although UTK exposure significantly decreased egg production, neither TK nor CMO caused any reproductive changes. The expression of six genes responsive to endocrine-disrupting compounds, stress, or metals was then examined in livers of these fish using real-time polymerase chain reaction. In female FHMs, none of the three effluents induced significant expression changes in any genes investigated. By contrast, in males there were significant increases in the mRNA levels of androgen receptor, estrogen receptor (ER) β, and cytochrome P4501A (CYP1A) upon UTK and TK exposure but no changes in ERα or vitellogenin (VTG) gene expression, whereas CMO exposure significantly increased the mRNA levels of ERα, VTG, and CYP1A. Together, these results suggest that kraft effluent before and after biological treatment contained compounds able to induce androgenic effects in FHMs, and that combination of kraft and newsmill effluents eliminated the androgenic compounds while inducing distinct and significant patterns of gene expression changes that were likely due to estrogenic compounds produced by the newsmill. Environ. Toxicol. Chem. 2010;29:430–439. © 2009 SETAC
Estimating potential risks to terrestrial invertebrates and plants exposed to bisphenol A in soil amended with activated sludge biosolids
Authors: Staples Charles , Friederich Urs , Hall Tilghman , Klečka Gary , Mihaich Ellen , Ortego Lisa , Caspers Norbert , Hentges Steven 
Published: March 2010

Abstract
Bisphenol A (BPA) is a high production volume substance primarily used to produce polycarbonate plastic and epoxy resins. During manufacture and use, BPA may enter wastewater treatment plants. During treatment, BPA may become adsorbed to activated sludge biosolids, which may expose soil organisms to BPA if added to soil as an amendment. To evaluate potential risks to organisms that make up the base of the terrestrial food web (i.e., invertebrates and plants) in accordance with international regulatory practice, toxicity tests were conducted with potworms (Enchytraeids) and springtails (Collembolans) in artificial soil, and six plant types using natural soil. No-observed-effect concentrations (NOEC) for potworms and springtails were equal to or greater than 100 and equal to or greater than 500 mg/kg (dry wt), respectively. The lowest organic matter-normalized NOEC among all tests (dry shoot weight of tomatoes) was 37 mg/kg-dry weight. Dividing by an assessment factor of 10, a predicted-no-effect concentration in soil (PNECsoil) of 3.7 mg/kg-dry weight was calculated. Following international regulatory guidance, BPA concentrations in soil hypothetically amended with biosolids were calculated using published BPA concentrations in biosolids. The upper 95th percentile BPA biosolids concentration in North America is 14.2 mg/kg-dry weight, and in Europe is 95 mg/kg-dry weight. Based on recommended biosolids application rates, predicted BPA concentrations in soil (PECsoil) would be 0.021 mg/kg-dry weight for North America and 0.14 mg/kg-dry weight for Europe. Hazard quotients (ratio of PECsoil and PNECsoil) for BPA were all equal to or less than 0.04. This indicates that risks to representative invertebrates and plants at the base of the terrestrial food web are low if exposed to BPA in soil amended with activated sludge biosolids. Environ. Toxicol. Chem. 2010;29:467–475. © 2009 SETAC
Error analysis of predicted fate of anthracene in a simulated pond
Authors: Bartell Steven M. , Gardner Robert H. , O'Neill Robert V. , Giddings Jeffrey M. 
Published: March 2010

Abstract
Statistical regressions that relate rates of transport processes to chemical characteristics of polycyclic aromatic hydrocarbons were used to estimate parameters in a model that predicts the fate of a simulated anthracene spill onto the surface (25 m2) of a 12.5 m3 pond ecosystem. During 60 d following a simulated spill of 2.0 g/m2 anthracene, predicted concentration in sediments peaked at 550 μg/m2. Predicted bioaccumulation was maximal in rooted macrophytes (0.35 μg/g dry weight), followed by benthic invertebrates (0.23 μg/g dry weight) and zooplankton (0.04 μg/g dry weight). Precision of predicted concentrations depends upon precise estimation of model parameters that define maximum water solubility and that regulate photolytic degradation, volatilization, sorption and bioaccumulation of anthracene. In 200 simulations, values of 29 model parameters were chosen at random from distributions with standard deviations that ranged between 0.5 and 53% of their means. Results demonstrate greater precision in predictions of the relative distribution of anthracene among water, sediments and total biota than precision of predicted concentrations of individual pond components.