bluuebunny/crossref_metadata_2025_split huggingface dataset:
AMPK and glucose deprivation exert an isoform-specific effect on the expression of Na+,K+-ATPase subunits in cultured myotubes
Authors: Vidović Anja , Dolinar Klemen , Chibalin Alexander V. , Pirkmajer Sergej 
Published: May 2024

AbstractIn skeletal muscle, Na+,K+-ATPase (NKA), a heterodimeric (α/β) P-type ATPase, has an essential role in maintenance of Na+ and K+ homeostasis, excitability, and contractility. AMP-activated protein kinase (AMPK), an energy sensor, increases the membrane abundance and activity of NKA in L6 myotubes, but its potential role in regulation of NKA content in skeletal muscle, which determines maximum capacity for Na+ and K+ transport, has not been clearly delineated. We examined whether energy stress and/or AMPK affect expression of NKA subunits in rat L6 and primary human myotubes. Energy stress, induced by glucose deprivation, increased protein content of NKAα1 and NKAα2 in L6 myotubes, while decreasing the content of NKAα1 in human myotubes. Pharmacological AMPK activators (AICAR, A-769662, and diflunisal) modulated expression of NKA subunits, but their effects only partially mimicked those that occurred in response to glucose deprivation, indicating that AMPK does not mediate all effects of energy stress on NKA expression. Gene silencing of AMPKα1/α2 increased protein levels of NKAα1 in L6 myotubes and NKAα1 mRNA levels in human myotubes, while decreasing NKAα2 protein levels in L6 myotubes. Collectively, our results suggest a role for energy stress and AMPK in modulation of NKA expression in skeletal muscle. However, their modulatory effects were not conserved between L6 myotubes and primary human myotubes, which suggests that coupling between energy stress, AMPK, and regulation of NKA expression in vitro depends on skeletal muscle cell model.
Modelling Afthairetic Modality
Authors: Venturi Giorgio , Yago Pedro 
Published: May 2024

AbstractDespite their controversial ontological status, the discussion on arbitrary objects has been reignited in recent years. According to the supporting views, they present interesting and unique qualities. Among those, two define their nature: their assuming of values, and the way in which they present properties. Leon Horsten has advanced a particular view on arbitrary objects which thoroughly describes the earlier, arguing they assume values according to a sui generis modality, which he calls afthairetic. In this paper, we offer a general method for defining the minimal system of this modality for any given first-order theory, and possible extensions of it that incorporate further aspects of Horsten’s account. The minimal system presents an unconventional inference rule, which deals with two different notions of derivability. For this reason and the failure of the Necessitation rule, in its full generality, the resulting system is non-normal. Then, we provide conditional soundness and completeness results for the minimal system and its extensions.
“I Felt Like I Was Cut in Two”: Postcesarean Bodies and Complementary and Alternative Medicine in Switzerland
Authors: Chautems Caroline 
Published: May 2024

AbstractIn neoliberal cultural contexts, where the ideal prevails that female bodies should be unchanged by reproductive processes, women often feel uncomfortable with their postpartum bodies. Cesareaned women suffer from additional discomfort during the postpartum period, and cesarean births are associated with less satisfying childbirth experiences, fostering feelings of failure among women who had planned a vaginal delivery. In Switzerland, one in three deliveries is a cesarean. Despite the frequency of this surgery, women complain that their biomedical follow-up provides minimal postpartum support. Complementary and alternative medicine (CAM) therapists address these issues by providing somatic and emotional postcesarean care. CAM is heavily gendered in that practitioners and users are overwhelmingly women and in that most CAM approaches rely on the essentialization of bodies. Based on interviews with cesareaned women and with CAM therapists specialized in postcesarean recovery, I explore women’s postpartum experiences and how they reclaim their postcesarean bodies.
Unveiling Trichosporon austroamericanum sp. nov.: A Novel Emerging Opportunistic Basidiomycetous Yeast Species
Authors: Francisco Elaine C. , Desnos-Ollivier Marie , Dieleman Chendo , Boekhout Teun , Santos Daniel Wagner de C. L. , Medina-Pestana José O. , Colombo Arnaldo L. , Hagen Ferry 
Published: May 2024

AbstractDuring an epidemiological survey, a potential novel species within the basidiomycetous yeast genus Trichosporon was observed. The clinical strain was obtained from a urine sample taken from a Brazilian kidney transplant recipient. The strain was molecularly identified using the intergenic spacer (IGS1) ribosomal DNA locus and a subsequent phylogenetic analysis showed that multiple strains that were previously reported by other studies shared an identical IGS1-genotype most closely related to that of Trichosporon inkin. However, none of these studies provided an in-depth characterization of the involved strains to describe it as a new taxon. Here, we present the novel clinically relevant yeast for which we propose the name Trichosporon austroamericanum sp. nov. (holotype CBS H-24937). T. austroamericanum can be distinguished from other siblings in the genus Trichosporon using morphological, physiological, and phylogenetic characters.
Use of complementary therapies and supportive measures of patients with intracranial gliomas—a prospective evaluation in an outpatient clinic
Authors: Ottenhausen Malte , Renovanz Mirjam , Bartz Isabell , Poplawski Alicia , Kalasauskas Darius , Krenzlin Harald , Keric Naureen , Ringel Florian 
Published: May 2024

Abstract
Purpose
Patients with intracranial gliomas frequently seek for complementary and alternative medicine (CAM), in addition to guideline-directed therapy. In this study, we therefore assessed patients’ information needs regarding treatment and support, and evaluated their attitudes toward experimental trials and alternative therapies.

Methods
A prospective, cross-sectional, descriptive survey was conducted in our center. We developed an interview focusing on how patients obtain further information about therapy and the use of alternative/complementary therapies.

Results
A total of 102 patients participated in the survey. 50% (n = 51) of patients reported that they had not attempted any additional therapies. When patients attempted self-therapy, it was most commonly in the areas of nutrition (25%, n = 26) and dietary supplements (17%, n = 17). Alternative or complementary therapies were used by 14% (n = 14) of the patients. Younger age (Odds ratio (OR) 0.96 (95% Confidence interval (CI) 0.92–0.99, p = 0.012) and tumor entity (OR 5.01 (95% CI 1.66–15.11, p = 0.004) for grade 4 vs. 3 tumors and OR 7.22 (95% CI 1.99–26.28) for grade 4 vs. other tumors p = 0.003) were significantly associated with a greater interest in CAM.

Conclusions
Interest in complementary and alternative medicine, as well as nutrition and dietary supplements is high (51%) among glioma patients, and significantly higher among younger patients and those with a worse diagnosis (WHO grade 4). A comprehensive approach to information, including paramedical topics, is needed to provide optimal patient counseling and care for glioma patients.
Preschool teachers’ literacy beliefs, their evaluations of children’s writing, and their recommendations for ways to support it
Authors: Besser-Biron Shira , Bergman Deitcher Deborah , Elimelech Adi , Aram Dorit 
Published: May 2024

AbstractPreschool teachers’ literacy-related beliefs and literacy knowledge relate to their educational practices and preschoolers’ literacy skills. In this light, we explored how preschool teachers’ beliefs regarding early literacy and its promotion predict their knowledge, reflected in how they evaluate three young children’s writing products and their recommendations for ways to promote these children’s writing, taking into consideration teacher and classroom variables (teacher training, preschool age group, and preschool SES). Participants were 110 teachers of preschoolers (aged 4–6). The teachers completed a literacy beliefs questionnaire. They were then presented with three products written by anonymous 5.5-year-old preschoolers, representing three writing levels: initial, intermediate, and advanced, and asked what each child knows about writing and recommendations for how they can be promoted. Responses were coded for the following aspects: letters, phonology, orthography, the writing system, and composing. Results showed that preschool teachers believe children’s early literacy and its promotion are important, and that these beliefs predicted some of their evaluations and recommendations. In the evaluations, the teachers did not relate at all to composing. They related primarily to letters and phonology, both in their assessments of the children’s knowledge and their recommendations for promoting the children’s writing. At more advanced writing levels, they also related to Hebrew orthography and the writing system, and made recommendations regarding these aspects. The study suggests that preschool teachers should be encouraged to incorporate composing and more complex aspects of writing into their writing activities and instruction.
Hemodynamic gain index and risk of chronic kidney disease: A prospective cohort study of middle-aged and older men
Authors: Kunutsor Setor K. , Laukkanen Jari A. 
Published: May 2024

AbstractThe hemodynamic gain index (HGI), a novel non-invasive hemodynamic marker, represents a promising advancement in cardiovascular risk assessment. Cardiovascular disease and chronic kidney disease (CKD) are closely intertwined and share bidirectional relationships. We aimed to assess the association of HGI with CKD risk in a prospective study. Hemodynamic gain index was calculated using heart rate and systolic blood pressure (SBP) responses measured in 1765 men aged 42–61 years with normal kidney function during exercise testing using the formula: [(Heart ratemax x SBPmax)—(Heart raterest x SBPrest)]/(Heart raterest x SBPrest). Multivariable adjusted hazard ratios (HRs) (95% confidence intervals, CIs) were estimated for CKD. Over a median follow-up duration of 25.9 years, 175 CKD cases occurred. In analysis adjusted for established risk factors, a unit (bpm/mmHg) higher HGI was associated with a decreased risk of CKD (HR 0.78, 95% CI 0.65–0.95). Comparing extreme tertiles of HGI, the corresponding adjusted HR (95% CI) for CKD was 0.53 (0.33–0.85). Addition of HGI to a CKD risk prediction model containing established risk factors improved risk discrimination and reclassification (p-value for difference in -2 log likelihood = .011; net-reclassification-improvement = 59.37%, p = .018; integrated-discrimination-improvement = 0.0064, p = .008). Higher HGI is associated with a lower CKD risk and improves the prediction and classification of CKD beyond common established risk factors.
Design and architecture of a slender and flexible underwater robot
Authors: Wang Jia-Lin , Song Jia-Ling , Liu Ai-Rong , Liang Jia-Qiao , Zhou Fo-Bao , Liang Jia-Jian , Fu Ji-Yang , Chen Bing-Cong 
Published: May 2024

AbstractThis paper presents the design and analysis of a biomimetic underwater snake-like robot, addressing the main limitations of current underwater robotic systems in terms of maneuverability and adaptability in complex environments. The innovative design incorporates flexible joint modules that significantly enhance the robot’s ability to navigate through narrow and irregular terrains, which is a notable limitation in traditional rigidly connected underwater robots. These flexible joints provide increased degrees of freedom and enable the robot to absorb and release energy, ensuring stability even under external impacts, thus extending the operational lifespan of the robot. Finite element analysis demonstrates the flexible joints’ superior performance in various underwater conditions, offering a greater range of motion and workspace compared to rigid connections. The results indicate that the robot’s modular design, combined with the flexible joint module, leads to improved agility and maneuverability, allowing for precise and intentional operation. The control module, equipped with advanced sensors and a CPU, manages the complex dynamics introduced by the flexible joints, ensuring effective navigation and operation. The specific advantages of this design include the robot’s enhanced structural integrity, its ability to conform to irregular surfaces, and its adaptability to environmental variations. The paper concludes with a discussion on the implications of these findings for the future design and operation of underwater serpentine robots, emphasizing the need for a balance between the effects of elastic modulus and workspace to maximize the benefits of flexible joints.
Using Photovoice to Improve Engagement in Community Health Assessments Addressing Behavioral Health
Authors: Li Stacey , Gulley Jennifer , Booty Marisa , Firchow Bradley , McGladrey Margaret L. 
Published: May 2024

AbstractBehavioral health disorders are well-known to have close links with the social determinants of health, yet little is known about how impacted communities perceive these links. Qualitative participatory methods can not only provide insight into how communities conceptualize these relationships but also empower those with lived experience to contextualize their perspectives and formulate calls to action. This study used Photovoice as a participatory method to supplement the Clark County Health Department Community Health Assessment and determine priority facilitators and barriers contributing to the behavioral health of Clark County, KY, residents. A secondary aim was to gain a greater understanding of how the Photovoice methodology impacts community engagement efforts in Community Health Assessments. Twenty-three Clark County residents participated in four Photovoice groups involving five weekly sessions, which included photograph “show and tell,” critical group dialogue, participatory analysis, and planning for dissemination. Secondary analysis of Photovoice focus group discussions revealed behavioral health facilitators and barriers were most influenced by (1) public sector unresponsiveness, (2) strong partnerships formed between community and grassroots organizations, and (3) the siloed division of responsibility between agencies and across sectors. The authors also found the Photovoice method successfully enhanced engagement and empowered those with lived experience to frame their perspectives of the behavioral health landscape. This project has implications for enhancing community engagement and empowerment in behavioral health–focused public health assessments and shaping policy to promote multi-sector collaboration.
Comparative analysis of residential building decarbonization policies in major economies: insights from the EU, China, and India
Authors: Xia-Bauer Chun , Gokarakonda Sriraj , Guo Siyue , Filippidou Faidra , Thomas Stefan , Maheshwari Jyoti R. , Vishwanathan Saritha Sudharmma 
Published: May 2024

AbstractThe global building sector, responsible for over 30% of CO2 emissions, necessitates urgent decarbonization efforts. This paper examines residential building decarbonization policies in three major economies—the European Union (EU), China, and India. It provides an overview of diverse policies through policy landscape analysis and delves into the design specifics with a detailed policy intensity analysis of building energy codes, information disclosure, and financial incentives in each region. Our findings reveal a diverse mix of policies targeting residential building decarbonization in all three regions. While the EU and China have long-established diverse policy instruments, India's building energy efficiency policies are relatively recent and limited. Detailed analyses of building energy codes, information disclosure, and financial incentives expose variations in ambition, scope, and implementation, even with shared policy instruments. Significant advancements in building energy codes, particularly in stringency and compliance checks, are evident in the EU and China. Conversely, India faces a notable obstacle with limited adoption of residential building energy codes, impacting its journey towards net-zero. The EU leads in building energy labelling policies, while China and India encounter various challenges hindering widespread implementation. Financial incentives across the three regions predominantly take the form of subsidies, potentially straining public budgets. The study concludes with reflections on the pressing need for future research extending beyond the operational phase of buildings.
Contraception and Menstrual Management in Transmasculine and Gender-Diverse Individuals
Authors: Chiem Adrian , Marcos Maria Cristina , Schwartz Beth I. 
Published: May 2024

Abstract
Purpose of Review
This review outlines the current evidence on the contraceptive and menstrual management methods that are used for transmasculine or gender-diverse (TGD) individuals, as well as the gaps in the literature for this population.

Recent Findings
Contraception and menstrual management continue to be an understudied area in the care of TGD individuals, with much of existing research extrapolated from cisgender populations. Emerging studies have looked at contraceptive and menstrual management choices and outcomes in adolescents and highlight the 52 mg LNG-IUD as an option that is efficacious for both indications, as well as high-dose progestin-only pills for menstrual suppression only.

Summary
The best method for contraception and menstrual management is the one a patient feels most comfortable using. Clinicians should work to understand the nuances and interplay of pregnancy prevention, menstruation, and gender dysphoria in TGD patients to help them achieve their goals. Further research on these topics that focus on TGD populations is needed to better drive current recommendations and guidelines in supporting a vulnerable population.
How natural language processing derived techniques are used on biological data: a systematic review
Authors: Oikonomou Emmanouil D. , Karvelis Petros , Giannakeas Nikolaos , Vrachatis Aristidis , Glavas Evripidis , Tzallas Alexandros T. 
Published: May 2024

AbstractThe decoding of the human genome, completed two decades ago, marked a revolutionary moment in biology by introducing a vast amount of data. This avalanche of information presented several computational challenges. Machine Learning has become the dominant method to address these challenges, with Natural Language Processing playing a significant role and offering promising results. In this systematic review, we will explore the application of Machine Learning and Natural Language Processing to the study of biological data. On the one hand, Machine Learning is widely used in Artificial Intelligence to improve automation, carry out tasks that require no human interaction, and perform analytical and physical activities. It helps advance our understanding of biology and improve healthcare and drug development processes in bioinformatics. On the other hand, improved machine-human language interaction is the aim of Natural Language Processing. Its three main goals are character sequence processing, pattern recognition, and algorithm development. The use of Natural Language Processing is becoming increasingly important for the analysis of omics data using both modern and conventional Machine Learning models, underscoring the necessity for a systematic review. In this work, 82 studies were included following the PRISMA guidelines, sourced from PubMed, Scopus and IEEE Xplore on April 4th, 2023. The evaluation of the publications was based on the type of the studied biological data and the employed NLP techniques. Through our in-depth exploration of NLP approaches, we highlight their significance and potential in advancing the field of bioinformatics.
Influence of Preterm Birth and Low Birthweight on Physical Fitness: A Systematic Review, Meta-Analysis, and Meta-Regression
Authors: Martínez-Zamora Marcos D. , Martín-Martínez Carlos , Martínez-de-Quel Óscar , Valenzuela Pedro L. 
Published: May 2024

Abstract
Background
Preterm birth and low birthweight (LBW) might be associated with reduced physical fitness, although evidence remains inconclusive.

Objective
To examine the influence of preterm birth and LBW on physical fitness, as well as to assess whether variables such as gestational age, birthweight, or age at assessment moderate these effects.

Methods
PubMed, Scopus, and PsycINFO were systematically searched from inception to 7 December 2023 for case–control and cohort studies analyzing the association between preterm birth or LBW (or gestational age or birthweight as continuous variables) with at least one physical fitness-related outcome (i.e., cardiorespiratory fitness (CRF), muscle strength, flexibility, speed, agility). Random-effects meta-analysis and meta-regression models were used to estimate the pooled effect size, as well as to examine potential associations between the magnitude of the effect and gestational age, birthweight, or age at assessment.

Results
Fifty-two studies (n = 920,603 participants, average age ranging from 4.7 to 34.4 years) were included. Preterm birth was associated with reduced CRF (standardized mean difference (SMD) = −0.38, 95% confidence interval (CI) = −0.51 to −0.25) and muscle strength (SMD = −0.44, 95% CI = −0.79 to −0.08). LBW was associated with reduced CRF (SMD = −0.40, 95% CI = −0.64 to −0.17), muscle strength (SMD = −0.18, 95% CI = −0.24 to −0.13), flexibility (SMD = −0.11, 95% CI = −0.22 to −0.01), and agility (SMD = −0.99, 95% CI = −1.91 to −0.07). Meta-regression analyses showed that a lower gestational age or birthweight were associated with larger reductions in physical fitness, whereas no consistent association was found for the age at assessment.

Conclusion
Both preterm birth and LBW seem associated with reduced physical fitness regardless of age, with larger reductions overall observed in individuals with lower gestational age or birthweight. These findings might support the implementation of preventive strategies (e.g., fitness monitoring and physical exercise interventions) in these populations through the life course.
PROSPERO registration: CRD42021231845.

Graphical Abstract