bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cognitive outcome of parietooccipital resection in children with epilepsy
Authors: Lippé Sarah , Bulteau Christine , Dorfmuller Georg , Audren François , Delalande Olivier , Jambaqué Isabelle 
Published: June 2010

SummaryPurpose:  We followed the neuropsychological development of five children who underwent unilateral neurosurgery of the occipitoparietal lobes as a treatment for epilepsy caused by a developmental lesion (cortical dysplasia).Methods:  The follow‐up period ranged from 3–7 years postsurgery.Results:  Two participants had a verbal intelligence quotient (IQ) >100 and three had a verbal IQ between 65 and 80. All five children had abnormal nonverbal IQ and exhibited deficits related to visual attention, object recognition, and praxis. Nevertheless, our results suggest that brain plasticity after parietooccipital epilepsy surgery in young children allows for a schooling level of cognitive skills such as reading and arithmetic.Discussion:  Although recovery for visual perceptual cognition was more limited than for verbal functions, long‐term neuropsychological outcomes showed that early surgery for epilepsy offers the possibility of optimizing cognitive outcomes in children with posterior intractable epilepsies.
Reduction in potassium concentration of stored red blood cell units using a resin filter
Authors: Yamada Chisa , Heitmiller Eugenie S. , Ness Paul M. , King Karen E. 
Published: June 2010

BACKGROUND: Hyperkalemia is a serious complication of rapid and massive blood transfusion due to high plasma potassium (K) in stored red blood cell (RBC) units. A potassium adsorption filter (PAF) was developed in Japan to remove K by exchanging with sodium (Na). We performed an in vitro evaluation of its efficacy and feasibility of use.STUDY DESIGN AND METHODS: Three AS‐3 RBC units were filtered by each PAF using gravity; 10 PAFs were tested. Blood group, age, flow rate, and irradiation status were recorded. Total volume, K, Na, Cl, Mg, total Ca (tCa), RBC count, hemoglobin (Hb), hematocrit (Hct), and plasma Hb were measured before and after filtering each unit. Ionized Ca (iCa), pH, and glucose were measured for some units.RESULTS: After filtration, the mean decrease in K was 97.5% in the first RBC unit, 91.2% in the second unit, and 64.4% in the third unit. The mean increases in Na, Mg, and tCa were 33.0, 151.4, and 116.1%, respectively. iCa and pH remained low; glucose was unchanged. RBC count, Hb, and Hct decreased slightly after filtration of first units; plasma Hb was unchanged. After filtration, there was no visual evidence of increased hemolysis or clot formation.CONCLUSION: The PAF decreased K concentration in stored AS‐3 RBC units to minimal levels in the first and second RBC units. Optimally, one filter could be used for 2 RBC units. Although Na increased, the level may not be clinically significant. PAF may be useful for at‐risk patients receiving older units or blood that has been stored after gamma irradiation.
Delayed recovery after autologous peripheral hematopoietic cell transplantation: potential effect of a high number of total nucleated cells in the graft
Authors: Trébéden‐Negre Hélène , Rosenzwajg Michelle , Tanguy Marie‐Laure , Lefrere François , Azar Nabih , Heshmati Farhad , Belhocine Ramdane , Vernant Jean‐Paul , Klatzmann David , Norol Françoise 
Published: June 2010

BACKGROUND: Some patients demonstrate delayed recoveries after autologous hematopoietic stem cell transplantation despite infusion of an adequate number of CD34+ cells/kg and clinically stable status. Factors considered being possible predictors of this outcome in this context were explored.STUDY DESIGN AND METHODS: A total of 246 patients were evaluated in terms of engraftment. Delayed recovery was defined by white blood cell recovery time exceeding mean + 1 SEM. Clinical factors and graft characteristics were examined. Comparisons between patients with normal or delayed engraftment were made. Proinflammatory cytokines and proteolytic enzyme quantification and CXCR4+ and CD44+ cell enumeration were performed on peripheral hematopoietic stem cells (PHSC) product samples of patients with delayed engraftment and patients with usual engraftment time.RESULTS: Sixteen patients, who received at least 3 × 106 CD34+ cells/kg without known clinical factors likely to affect engraftment, demonstrated a delayed recovery time of over 20 days. Some graft variables were found to be significantly increased in these patients by univariate analysis. One variable was the total number of nucleated cells cryopreserved and infused. Among the nucleated cells, the absolute number of granulocytes before and after cryopreservation also differed significantly between the two groups. A multivariate analysis showed that the main predictive factor for delayed recovery was the number of nucleated cells in the graft (p = 0.0044). The influence of contaminating cells might be related to the release of elastase, matrix metalloproteinase‐9, interleukin (IL)‐1β, and IL‐6 involved in stem cell homing.CONCLUSION: Therefore, the numeration of total nucleated cells and granulocytes should be considered as a possible quality control variable of PHSCs submitted for cryopreservation.
Atypical Presentation of Postpartum Cerebral Angiopathy Shown as a Small Penetrating Arterial Territory Infarct with Severe Peri‐Infarct Edema
Authors: Cho A‐Hyun , Lim Sung Chul , Kim Beum Saeng , Yang Dong Won , Shon Young‐Min 
Published: June 2010

ABSTRACT Postpartum cerebral angiopathy mostly occurs in the large or medium‐sized cerebral arteries. In this case, we aimed to report a case of postpartum cerebral angiopathy presented as an asymmetrical penetrating arterial territory infarct with severe surrounding vasogenic edema. A 26‐year‐old woman admitted because of sudden headache after an attack of seizure. On initial computerized tomography (CT), hypodense lesion in the right basal ganglia was observed. The diffusion‐weighted image on 5th day revealed focal acute ischemic infarction with surrounding extensive vasogenic edema in right basal ganglia. The CT angiography showed multifocal arterial narrowing of intracranial cerebral arteries that completely resolved on the follow‐up study. This case suggested that asymmetrical small penetrating arterial territory infarct can occur as an atypical presentation of postpartum cerebral angiopathy.
Voxel‐Based Morphometry and Voxel‐Based Relaxometry in Parkinsonian Variant of Multiple System Atrophy
Authors: Tzarouchi Loukia C. , Astrakas Loukas G. , Konitsiotis Spyridon , Tsouli Sofia , Margariti Persefoni , Zikou Anastasia , Argyropoulou Maria I. 
Published: June 2010

ABSTRACTBACKGROUND AND PURPOSE Multiple system atrophy (MSA) is a progressive neurodegenerative disorder divided into a parkinsonian (MSA‐P) and a cerebellar variant. The purpose of this study was to assess regional brain atrophy and iron content using Voxel‐based morphometry (VBM) and Voxel‐based relaxometry (VBR) respectively, in MSA‐P. METHODS Using biological parametric mapping the effect of brain atrophy was evaluated in T2 relaxation time (T2) measurements by applying analysis of covariance (ANCOVA) and correlation analysis to the VBM and VBR data. Eleven patients with MSA‐P (aged 61.9 ± 11.7 years, disease duration 5.42 ± 2.5 years) and 11 controls were studied. RESULTS In comparison to the controls the patients showed decreased gray matter in the putamen, the caudate nuclei, the thalami, the anterior cerebellar lobes, and the cerebral cortex, and white matter atrophy in the pons, midbrain, and peduncles. VBR analysis showed prolonged T2 in various cortical regions. On ANCOVA, when controlling for gray and white matter volume, these regions of prolonged T2 were shrunk. Negative correlation was demonstrated between T2 and gray and white matter volume. CONCLUSIONS Diffuse brain atrophy, mainly in the motor circuitry is observed in MSA‐P. Normalization for atrophy should always be performed in T2 measurements.
Intra‐arterial Administration of Microbubbles and Continuous 2‐MHz Ultrasound Insonation to Enhance Intra‐arterial Thrombolysis
Authors: Ribo Marc , Molina Carlos A. , Alvarez Beatriz , Rubiera Marta , Alvarez‐Sabin Jose , Matas Manel 
Published: June 2010

ABSTRACTBACKGROUND Microbubbles (MB) and ultrasound have been shown to enhance thrombolysis. We sought to evaluate safety and efficacy on middle cerebral artery (MCA) recanalization of local MB administration during intra‐arterial (IA) thrombolysis and continuous transcranial Doppler (TCD) monitoring. METHODS Patients with acute M1‐MCA occlusion were treated with intravenous tissue plasminogen activator (iv‐tPA) and continuously monitored with TCD. If recanalization was not achieved during first‐hour bridging IA‐rescue was adopted: MB + tPA direct intraclot microcatheter infusion. TCD flow monitoring allowed continuous insonation at clot location. Recanalization was angiographically assessed (thrombolysis in cerebral infarction [TICI] score) and compared with simultaneous TCD data. IA procedures were stopped at 6 hours. Recanalization was reassessed at 12 hours (TCD). Neurological status was repeatedly assessed (National Institutes of Health Stroke Scale [NIHSS]). At three months, patients were considered independent if mRS ≤ 2. RESULTS Of the 18 included patients (mean age 72), 16 received standard iv‐tPA (.9 mg/kg). Nine patients were recanalized during tPA infusion and 9 patients underwent IA‐rescue procedures. Median pre‐IA NIHSS score: 20. Median time to IA initiation was 175 ± 63 minutes. Mean IA doses were tPA = 10 ± 3 mg and MB = 3 ± 1 mL. TCD monitoring allowed direct visualization of massive MB arrival during every administration. In‐procedure recanalization was observed in 78% (n= 7): complete‐TICI3 in 22% (n= 2), partial‐TICI2 in 56% (n= 5). Perfect correlation was observed between TICI and TCD scores. At 12 hours complete recanalization increased to 56%, partial to 22%. One patient (11%) experienced symptomatic intracranial hemorrhage accounting for the only death. Median NIHSS evolution was 12 at 24 hours and 10 at discharge. At 3 months 4 patients (44%) were independent. CONCLUSION The combination of ultrasound and IA MB and tPA may be a strategy to enhance the thrombolytic effect and increase recanalization rates.
Cerebral Atrophy in Cerebrovascular Disorders
Authors: Jouvent Eric , Viswanathan Anand , Chabriat Hugues 
Published: June 2010

ABSTRACTBACKGROUND AND PURPOSE Various neurological disorders have been shown to accelerate the natural course of brain volume loss during normal aging. Recent data suggest that brain atrophy is prominent in various cerebrovascular disorders. Studies of the effects of different cerebrovascular magnetic resonance imaging (MRI) markers and of the effects of various vascular risk factors on the cerebral volume have been analyzed. SUMMARY OF REVIEW A significant association between white matter hyperintensities and cerebral atrophy has been reported in population‐based studies. However, these results remain controversial since they have not yet been confirmed in longitudinal studies. The association between lacunar infarctions and cerebral atrophy was only rarely investigated. This was also true for cerebral microbleeds. In contrast, different data suggest that brain atrophy is associated with elevated blood pressure values or hyperglycemia, independent of the occurrence of extension of visible MRI markers of vascular lesions. CONCLUSION Additional studies are needed to determine the exact impact of vascular risk factors or other cerebrovascular lesions seen on MRI on the course of cerebral atrophy. In the future, new MRI markers may help to better delineate the role of focal tissue lesions from that of diffuse effects of vascular risk factors on the cerebral atrophy process.
Comparison of Diffusion Tensor‐Based Tractography and Quantified Brain Atrophy for Analyzing Demyelination and Axonal Loss in MS
Authors: Fink Frauke , Klein Jan , Lanz Michael , Mitrovics Tibor , Lentschig Markus , Hahn Horst K. , Hildebrandt Helmut 
Published: June 2010

ABSTRACT We combined diffusion tensor imaging (DTI) measures of the corpus callosum (CC) and the superior longitudinal fascicle (SLF) with calculation of brain atrophy in 53 patients with relapsing—remitting multiple sclerosis (MS) and 15 healthy controls, to analyze their interrelation and their correlation with disease duration and clinical impairment. The lateral ventricle volume in MS patients was increased; the fractional anisotropy in the CC was decreased as was the fiber volume. Perpendicular (in the literature also referred to as radial) diffusivity (ped), which reflects the diffusion perpendicular to the long axis of the axons within the fiber bundle, was increased in the SLF and the posterior CC, but contrary to our predictions, parallel (also called axial) diffusivity (pad) that refers to the amount of diffusion in the direction of the axon was increased, too. Brain atrophy and DTI‐derived parameters were highly intercorrelated and both correlated with disease duration. Discriminant analysis showed that DTI‐derived atrophy measures are superior to brain atrophy measures in classifying patients and controls. In light of our results, animal studies focusing on demyelination and axonal loss are reinterpreted.
Pseudo‐Guillain‐Barre Syndrome Due to “Whippet”‐Induced Myeloneuropathy
Authors: Tatum William O. , Bui Daniel D. , Grant Edmund G. , Murtagh Ryan 
Published: June 2010

ABSTRACT Guillain‐Barre syndrome (GBS) is the rubric encompassing highly variable phenotypic subgroups of acute, postinfectious, immune‐mediated peripheral neuropathy. The hallmark of GBS phenomenology is a rapidly progressive ascending lower extremity weakness. GBS taxonomy includes a motor and sensory axonal neuropathy (AMSAN). Nitrous oxide (NO) abuse may create a pattern of neurological dysfunction almost identical to subacute combined degeneration. We report an adult with myeloneuropathy due to NO abuse that mimicked the presenting features of the GBS‐subtype AMSAN.
Intraaneurysmal Neuroform Stent Implantation with Compartmental Dual Microcatheter Coil Embolization: Technical Case Report
Authors: Gordhan Ajeet D. 
Published: June 2010

ABSTRACTBACKGROUND AND PURPOSE A complex middle cerebral artery (MCA) aneurysm failed surgical clipping. The aneurysm morphology was characterized by a broad neck with incorporated diminutive branch vasculature and mural calcification. To preserve flow within incorporated branch vessels, coil embolization with intraaneurysmal Neuroform stent implantation was achieved with a novel technique. METHODS AND RESULTS A 52‐year‐old female presented with an unruptured complex configuration right MCA bifurcation aneurysm. Endovascular coil embolization with intraaneurysmal stent deployment and compartmental dual microcatheter placement was performed a month after failed surgical clipping. Successful occlusion of the aneurysm with coil packing within and external to the stent was achieved with preservation of flow to the branch vessels. CONCLUSIONS Neuroform stent implantation within the aneurysm lumen and subsequent dual catheter coil embolization of the compartments external and internal to the stent is useful for successful occlusion of complex configuration cerebral aneurysms with incorporated branch vasculature.
Mandibular implant‐supported overdentures and oral function
Authors: Van Der Bilt Andries , Burgers M. , Van Kampen F.M.C. , Cune M.S. 
Published: June 2010

AbstractObjectives: Oral rehabilitation by means of implant‐retained mandibular overdentures is known to improve oral function. The aim of this study was to evaluate the long‐term effects of mandibular implant treatment on oral function. We quantified maximum bite force and masticatory performance 10 years after implant treatment. It was hypothesized that these outcome measures would not change in this period.Materials and methods: Eighteen edentulous patients were scheduled for re‐evaluation of their oral function 10 years after they had participated in a randomized cross‐over clinical trial. In that trial, they had received two mandibular implants and a new denture with successively magnet‐, ball‐socket, and bar‐clip attachments.Results: At the 10‐year follow‐up, 14 of the initial 18 patients participated in the evaluation. As a result of the implant treatment, the average maximum bite force more than doubled, from 162 to 341 N, whereas the average number of chewing cycles to halve the initial partcle size decreased from 55 to 27 cycles. No significant changes in maximum bite force and masticatory performance were observed after 10 years. However, the average maximum bite force obtained with implant‐retained overdentures is still significantly lower than that of dentate subjects (569 N).Conclusion: Maximum bite force and masticatory performance significantly increased after implant treatment and remained unaltered during the following 10‐year period. Thus, implant treatment greatly improves oral function for a long period of time. To cite this article:
van der Bilt A, Burgers M, van Kampen FMC, Cune MS. Mandibular implant‐supported overdentures and oral function. Clin. Oral Impl. Res. 21, 2010; 1209–1213. doi: 10.1111/j.1600‐0501.2010.01915.x
MMP‐13 expression in keratocyst odontogenic tumour associated with NBCCS and sporadic keratocysts
Authors: Leonardi R , Matthews JB , Caltabiano R , Greco M , Lombardo C , Loreto C , Santarelli A , Lo Muzio L 
Published: June 2010

Oral Diseases (2010) 16, 795–800Objective:  To investigate the matrix metalloproteinase (MMP)‐13 expression in associated and non‐nevoid basal cell carcinoma syndrome (NBCCS) Odontogenic Keratocysts (OCKs) in order to contribute to a better understanding of the differences in the growth pattern between them.Materials and methods:  Thirty‐nine paraffin‐embedded blocks of OCKs, 26 sporadic OCKs and 11 NBCCS‐associated KCOTs were studied by immunohistochemistry to evaluate MMP‐13 expression both in epithelial and stromal layers. A semi‐quantitative scale was used to evaluate immunostaining. Obtained data were compared between the two groups, using Fischer’s exact test and the chi‐square test.Results:  Only 13 of 26 sporadic OCKs showed a positive immunostaining, whilst 11 KCOTs resulted in positive labelling for MMP‐13 expression. Moreover, syndromic cysts displayed a more intense and diffuse MMP‐13 labelling of the stromal tissue. Instead, in non‐syndromic forms, the staining pattern of MMP‐13 in stromal tissue was completely absent. Fisher's exact test showed a statistically significant greater prevalence of KCOTs‐immunolabelled cysts with respect to sporadic OCKs.Conclusions:  Results from this study point out that the biological behaviour of these cysts could be related not only to the epithelial layer but also to stromal tissue in that... MMP‐13 overexpression in stromal tissue of NBCCS‐associated KCOTs could clarify the higher aggressiveness of these cysts.
Bladder catheter–induced obstructive bilateral hydroureteronephrosis in a newborn
Authors: Allegaert Karel , Smet Marleen , Debeer Anne , Breysem Luc 
Published: June 2010

AbstractWe describe a dynamic, bladder catheter–related obstructive bilateral hydroureteronephrosis in a newborn documented during ultrasound. The normal findings at foetal ultrasound and the absence of muscular hypertrophy of the bladder hereby served as indicators of the iatrogenic nature of the initial abnormal ultrasound findings.Conclusion:  A Foley bladder catheter can induce obstructive bilateral hydroureteronephrosis in newborns.
Selection Bias in Web Surveys
Authors: Bethlehem Jelke 
Published: June 2010

Summary At first sight, web surveys seem to be an interesting and attractive means of data collection. They provide simple, cheap, and fast access to a large group of potential respondents. However, web surveys are not without methodological problems. Specific groups in the populations are under‐represented because they have less access to Internet. Furthermore, recruitment of respondents is often based on self‐selection. Both under‐coverage and self‐selection may lead to biased estimates. This paper describes these methodological problems. It also explores the effect of various correction techniques (adjustment weighting and use of reference surveys). This all leads to the question whether properly design web surveys can be used for data collection. The paper attempts to answer this question. It concludes that under‐coverage problems may solve itself in the future, but that self‐selection leads to unreliable survey outcomes.
Corrigendum: ‘On certain algebraic curves related to polynomial maps, Compositio Math. 103 (1996), 319–350’
Authors: Morton Patrick 
Published: June 2010

AbstractAn argument is given to fill a gap in a proof in the author’s articleOn certain algebraic curves related to polynomial maps, Compositio Math. 103(1996), 319–350, that the polynomial Φn(x,c), whose roots are the periodic points of periodnof a certain polynomial mapx→f(x,c), is absolutely irreducible over the finite field of pelements, provided thatf(x,1) has distinct roots and that the multipliers of the orbits of periodnare also distinct over$\mathbb { F}_p$. Assuming that Φn(x,c) is reducible in characteristic p, we show that Hensel’s lemma and Laurent series expansions of the roots can be used to obtain a factorization of Φn(x,c) in characteristic 0, contradicting the absolute irreducibility of this polynomial over the rational field.
Clinical Efficacy of Combination of Rifampin and Streptomycin for Treatment ofMycobacterium ulceransDisease
Authors: Sarfo Fred Stephen , Phillips Richard , Asiedu Kingsley , Ampadu Edwin , Bobi Nana , Adentwe E. , Lartey Awuli , Tetteh Ishmael , Wansbrough-Jones M. 
Published: June 2010

ABSTRACTWe have evaluated the clinical efficacy of the combination of oral rifampin at 10 mg/kg of body weight and intramuscular streptomycin at 15 mg/kg for 8 weeks (RS8), as recommended by the WHO, in 160 PCR-confirmed cases ofMycobacterium ulceransdisease. In 152 patients (95%) with all forms of disease from early nodules to large ulcers, with or without edema, the lesions healed without recourse to surgery. Eight patients whose ulcers were healing poorly had skin grafting after completion of antibiotics. There were no recurrences among 158 patients reviewed at the 1-year follow-up. The times to complete healing ranged from 2 to 48 weeks, according to the type and size of the lesion, but the average rate of healing (rate of reduction in ulcer diameter) varied widely. Thirteen subjects had positive cultures forM. ulceransduring or after treatment, but all the lesions healed without further antibiotic treatment. Adverse events were rare. These results confirm the efficacy of RS8 delivered in a community setting.
Role of Methionine Sulfoxide Reductases A and B of
Enterococcus faecalis
in Oxidative Stress and Virulence
Authors: Zhao Chen , Hartke Axel , La Sorda Marilena , Posteraro Brunella , Laplace Jean-Marie , Auffray Yanick , Sanguinetti Maurizio 
Published: June 2010

ABSTRACT

Methionine sulfoxide reductases A and B are antioxidant repair enzymes that reduce the
S
- and
R
-diastereomers of methionine sulfoxides back to methionine, respectively.
Enterococcus faecalis
, an important nosocomial pathogen, has one
msrA
gene and one
msrB
gene situated in different parts of the chromosome. Promoters have been mapped and mutants have been constructed in two
E. faecalis
strains (strains JH2-2 and V583) and characterized. For both backgrounds, the mutants are more sensitive than the wild-type parents to exposure to H
2
O
2
, and in combination the mutations seem to be additive. The virulence of the mutants has been analyzed in four different models. Survival of the mutants inside mouse peritoneal macrophages stimulated with recombinant gamma interferon plus lipopolysaccharide but not in naïve phagocytes is significantly affected. The
msrA
mutant is attenuated in the
Galleria mellonella
insect model. Deficiency in either Msr enzyme reduced the level of virulence in a systemic and urinary tract infection model. Virulence was reconstituted in the complemented strains. The combined results show that Msr repair enzymes are important for the oxidative stress response, macrophage survival, and persistent infection with
E. faecalis.