bluuebunny/crossref_metadata_2025_split huggingface dataset:
One‐pot construction of polydopamine‐based superhydrophobic coating with enhanced chemical stability and anti‐fouling performance
Authors: Xia Gongwei , Xu Xiao , Chen Jianfang , Jiang Ruitao , Zheng Hao 
Published: May 2024

AbstractA facile strategy to construct superhydrophobic coatings was carried out by one‐pot process using novel nano zero‐valent iron and hydrogen peroxide as trigger in ethanol and Tris buffer mixed system containing dopamine and 1H,1H,2H,2H‐perfluorodecanethiol (PFDT) for the first time. The polydopamine (PDA) modified by PFDT composite coating can be deposited onto various substrates including glass slides, polyurethane sheets, polytetrafluoroethylene wafers, 304 stainless steel sheets, and polyurethane sponges, revealing excellent hydrophobicity with the water contact angles from 157.1° to 162.2° and the sliding angle lower than 1°. The flourier transformed infrared spectroscopy and x‐ray photoelectron spectroscopy information of the composite coating demonstrated the successful covalent interaction between catechol group in PDA and thiol group of PFDT via Michael addition reaction. As‐prepared PFDT/PDA composite coatings exhibited enhanced chemical stability in highly acidic solutions for 6 days, alkaline aqueous solutions for 5 days, salty solutions (3.5 wt%) for 28 days, and polar organic solvents for 24 h, respectively, as well as resistance to algae adhesion. The excellent corrosion resistance and chemical stability of the composite coating and their simple, time saving and inexpensive construction process are expected to be widely applied in various areas, including marine anti‐corrosion, anti‐fouling, and oil–water separation.
Role of small nucleolar RNAs in alternative splicing of the doublesex gene in the silkworm, Bombyx mori
Authors: Qian Yu‐Xin , Guo Shi‐Gang , Zhao Xu‐Hui , Li Zhong‐Wei , Qiu Reng , Kan Yun‐Chao , Li Dan‐Dan 
Published: May 2024

AbstractMore and more evidence shows that small noncoding RNAs (ncRNAs) play diverse roles in development, stress response and other cellular processes, but functional study of intermediate‐size ncRNAs is still rare. Here, the expression profile of 16 intermediate‐size ncRNAs in ovary and testis of silkworm Bombyx mori were analyzed. Twelve ncRNAs, including 5 small nucleolar RNAs (snoRNAs) and 7 unclassified ncRNAs, accumulated more in the testis than in the ovary of silkworm, especially Bm‐163, Bm‐51 and Bm‐68. Four ncRNAs (including three orphan snoRNAs and one unclassified ncRNA) had higher expression level in the ovary than in the testis, especially Bm‐86. Overexpression of the testis‐enriched snoRNA Bm‐68 in the female led to the accumulation of male‐specific isoform of doublesex (BmdsxM) and increased the expression ratio of BmdsxM: BmdsxF. While overexpression of ovary‐enriched snoRNA Bm‐86 in the male decreased the expression ratio of BmdsxM: BmdsxF, indicating the roles of the two snoRNAs played in the alternative splicing of Bmdsx of silkworm, which will provide new clues for the functional study of snoRNAs in insects.
Sneaked references: Fabricated reference metadata distort citation counts
Authors: Besançon Lonni , Cabanac Guillaume , Labbé Cyril , Magazinov Alexander 
Published: May 2024

AbstractWe report evidence of an undocumented method to manipulate citation counts involving “sneaked” references. Sneaked references are registered as metadata for published scientific articles in which they do not appear. This manipulation exploits trusted relationships between various actors: publishers, the Crossref metadata registration agency, digital libraries, and bibliometric platforms. By collecting metadata from various sources, we show that extra undue references are actually sneaked in at Digital Object Identifier (DOI) registration time, resulting in artificially inflated citation counts. As a case study, focusing on three journals from a given publisher, we identified at least 9% sneaked references () mainly benefiting two authors. Despite not being present in the published articles, these sneaked references exist in metadata registries and inappropriately propagate to bibliometric dashboards. Furthermore, we discovered “lost” references: the studied bibliometric platform failed to index at least 56% () of the references present in the HTML version of the publications. This research led to an investigation by Crossref (confirming our findings) and to subsequent corrective actions. The extent of the distortion—due to sneaked and lost references—in the global literature remains unknown and requires further investigations. Bibliometric platforms producing citation counts should identify, quantify, and correct these flaws to provide accurate data to their patrons and prevent further citation gaming.
Correlation Between Li‐Fe Anti‐Site and Memory Effect of LiFePO4 in Li‐Ion Batteries
Authors: Lu Xingguang , Ren Yuanyuan , Chen Daming , Guo Xiaolong , Li De , Chen Yong 
Published: May 2024

AbstractIn Li‐ion batteries, the origin of memory effect in Al‐doped Li4Ti5O12 has been revealed as the reversible Al‐ion switching between 8a and 16c sites in the spinel structure, but it is still not clear about that for olivine LiFePO4, which is one of the most important cathode materials. In this work, a series of Na‐doped and Ti‐doped LiFePO4 are prepared in a high‐temperature solid‐state method, electrochemically investigated in Li‐ion batteries and characterized by X‐Ray Diffraction (XRD), Fourier Transform Infrared Spectroscopy (FTIR) and Magic‐Angle‐Spinning Nuclear Magnetic Resonance (MAS NMR). Compared with non‐doped LiFePO4, the Ti doping can simultaneously suppress the memory effect and the Li−Fe anti‐site, while they are simultaneously enhanced by the Na doping. Meanwhile, the Ti doping improves the electrochemical performance of LiFePO4, opposite to the Na doping. Accordingly, a schematic diagram of phase transition is proposed to interpret the memory effect of LiFePO4, in which the memory effect is attributed to the defect of Li−Fe anti‐site.
Novel Pyrazole‐Chalcone Hybrids: Synthesis and Computational Insights Against Breast Cancer
Authors: Dabhade Pratap S. , Dabhade Manjushri P. , Rathod Lala S. , Dhawale Sachin A. , More Shweta A. , Chaudhari Somdatta Y. , Mokale Santosh N. 
Published: May 2024

AbstractMore women die of breast cancer than of any other malignancy. The resistance and toxicity of traditional hormone therapy created an urgent need for potential molecules for treating breast cancer effectively. Novel biphenyl‐substituted pyrazole chalcones linked to a pyrrolidine ring were designed by using a hybridization approach. The hybrids were assessed against MCF‐7 and MDA‐MB‐231 cells by NRU assay. Among them, 8 k, 8 d, 8 m, 8 h, and 8 f showed significantly potent IC50 values: 0.17, 5.48, 8.13, 20.51, and 23.61 μM) respectively, on MCF‐7 cells compared to the positive control Raloxifene and Tamoxifen. Furthermore, most active compound 8 k [3‐(3‐(4‐fluorophenyl)‐1‐phenyl‐1H‐pyrazol‐4‐yl)‐1‐(2‐(2‐(pyrrolidin‐1‐yl)‐ethoxy)‐phenyl)‐chalcone] showed cell death induced through apoptosis, cell cycle arrest at the G2/M phase, and demonstrated decrease of ER‐α protein in western blotting study. Docking studies of 8 k and 8 d established adequate interactions with estrogen receptor‐α as required for SERM binding. The active hybrids exhibited good pharmacokinetic properties for oral bioavailability and drug‐likeness. Whereas, RMSD, RMSF, and Rg values from Molecular dynamics studies stipulated stability of the complex formed between compound 8 k and receptor. All of these findings strongly indicate the antiproliferative potential of pyrazole‐chalcone hybrids for the treatment of breast cancer.
Capsaicin reverses cisplatin resistance in tongue squamous cell carcinoma by inhibiting the Warburg effect and facilitating mitochondrial‐dependent apoptosis via the AMPK/AKT/mTOR axis
Authors: Liu Xiayang , Li Zhuang , Zhao Qiwei , Zhou Xinyue , Wang Yu , Zhao Gang , Guo Xiaohong 
Published: May 2024

AbstractCisplatin is commonly used for the chemotherapy of tongue squamous cell carcinoma (TSCC); however, adverse side effects and drug resistance impact its therapeutic efficacy. Capsaicin is an active ingredient in chili peppers that exerts antitumor effects, whether it exerts antitumor effects on cisplatin‐resistant cells remains unknown. Therefore, in this study, we investigated the effect of capsaicin on cisplatin resistance in TSCC cells and explored the underlying mechanisms. A cisplatin‐resistant TSCC cell line was established by treated with increasing cisplatin concentrations. Combined treatment with cisplatin and capsaicin decreased the glucose consumption and lactate dehydrogenase activity and increased the adenosine triphosphate production both in vitro and in vivo, suggesting the inhibition of the Warburg effect. Moreover, this combined treatment induced cell apoptosis and significantly upregulated the levels of proapoptotic proteins, such as Bax, cleaved caspase‐3, ‐7, and ‐9, and apoptosis‐inducing factor. In contrast, levels of the antiapoptotic protein, Bcl‐2, were downregulated. Additionally, LKB1 and AMPK activities were stimulated, whereas those of AKT and mTOR were suppressed. Notably, AMPK knockdown abolished the inhibitory effects of capsaicin and cisplatin on the AKT/mTOR signaling pathway and Warburg effect. Overall, combined treatment with capsaicin and cisplatin reversed cisplatin resistance by inhibiting the Warburg effect and facilitating mitochondrial‐dependent apoptosis via the AMPK/AKT/mTOR axis. Our findings suggest combination therapy with capsaicin and cisplatin as a potentially novel strategy and highlight capsaicin as a promising adjuvant drug for TSCC treatment.
Homogeneous Iron Catalyzed C−H Amination
Authors: Possenti Dario , Olivo Giorgio 
Published: May 2024

AbstractIron‐catalyzed C−H amination is emerging as an attractive and sustainable method to install amine functionalities into organic compounds. Amination of C(sp3)−H bonds is usually mediated by an iron‐nitrene intermediate via a Hydrogen Atom Abstraction/Radical Recombination mechanism reminiscent of biomimetic C−H oxidation. Accordingly, this transformation can be catalyzed by engineered iron enzymes, heme and nonheme iron complexes as well as iron salts, although it is often limited to intramolecular reactions and/or activated positions. Aromatic C(sp2)−H amination is mediated by addition of electrophilic iron nitrenes or protonated N‐radical intermediates (produced with Fe catalysts) to aromatic systems. Again, high selectivity is obtained via (pseudo) intramolecular reactions. From a mechanistic perspective, several iron nitrene intermediates have been isolated and characterized over the years in different ligand scaffolds and iron oxidation states. Structure‐activity correlations have been drawn only in few cases and point to a key role of the spin density on the nitrene ligand and of the iron oxidation state. This review describes the state of the art for homogeneous iron catalyzed C(sp3)−H and C(sp2)−H amination focusing on the last 5 years (2019–2023) from a mechanism‐driven catalyst design perspective.
An Alternative Cascade for the Selective Methylation of Catechols and Tetrahydroisoquinolines by O‐Methyltransferases
Authors: Salinger Matthew T. , Castellano Garrido Daniel , Lamming Eleanor D. , Ward John M. , Moody Thomas S. , Jeffries Jack W. E. , Hailes Helen C. 
Published: May 2024

AbstractMethyltransferases are gaining traction as a method to achieve greener and regioselective methylations of a wide array of substrates. In this work, a halide methyltransferase biomethylation cascade was successfully adapted with the incorporation of a methionine adenosyltransferase to generate the S‐adenosyl‐L‐methionine (SAM) methylation cofactor in situ from less costly ATP and L‐methionine, instead of directly adding SAM to start the cascade. Furthermore, this cascade was applied to achieve novel catechol and tetrahydroisoquinoline methylations with the O‐methyltransferases RnCOMT, MxSafC and NpN4OMT with high conversions and regioselectivities. In addition, the cascade was successfully trialled with the less toxic methyl group donor, methyl tosylate.
Catalysed Aryl Amine Syntheses via Azides: From Azidation of Aryl Halides to Azide Reduction and Direct Amination
Authors: Roemer Max 
Published: May 2024

AbstractThis review summarises and discusses aryl amine and azide syntheses from aryl halides employing azides. The majority of the reported reactions proceed with copper catalysis or mediation. Often, an aryl azide is formed in the first step, which is then reduced in situ to an aryl amine in a second step. The occurrence of the second step, the reduction, depends on the chosen reaction conditions and the substrates. The formation of only aryl azides through Cu‐mediated C−N bond formations is discussed, followed by mediated and catalytic aryl azide reduction employing different catalytic systems, and azidation with in situ azide reduction to amines, viz. azidation‐amination strategies. The azidation‐amination allows for the synthesis of complex heterocycles in multi‐step one‐pot procedures, of which several are summarised here. Examples of the application of azidation‐amination for synthesising important aryl amines employed in or as biologically active compounds, catalysis and materials science are also summarised. Finally, conducted control reactions have been collected and discussed in combination with mechanistic proposals. This literature survey allows us to pinpoint design criteria for the azide reduction to valuable amines, which includes the choice of reaction conditions such as solvent system and additives, involved metal and promising substrates.
Grain Boundary Defect Engineering in Rutile Iridium Oxide Boosts Efficient and Stable Acidic Water Oxidation
Authors: Zhang Ning , Fan Yingqi , Wang Depeng , Yang Hong , Yu Yang , Liu Jianwei , Zeng Jianrong , Bao Di , Zhong Haixia , Zhang Xinbo 
Published: May 2024

AbstractProton exchange membrane water electrolysis (PEMWE) is considered a promising technology for coupling with renewable energy sources to achieve clean hydrogen production. However, constrained by the sluggish kinetics of the anodic oxygen evolution reaction (OER) and the acidic abominable environment render the grand challenges in developing the active and stable OER electrocatalyst, leading to low efficiency of PEMWE. Herein, we develop the rutile‐type IrO2 nanoparticles with abundant grain boundaries and the continuous nanostructure through the joule heating and sacrificial template method. The optimal candidate (350‐IrO2) demonstrates remarkable electrocatalytic activity and stability during the OER, presenting a promising advancement for efficient PEMWE. DFT calculations verified that grain boundaries can modulate the electronic structure of Ir sites and optimize the adsorption of oxygen intermediates, resulting in the accelerated kinetics. 350‐IrO2 affords a rapid OER process with 20 times higher mass activity (0.61 A mgIr−1) than the commercial IrO2 at 1.50 V vs. RHE. Benefiting from the reduced overpotential and the preservation of the stable rutile structure, 350‐IrO2 exhibits the stability of 200 h test at 10 mA cm−2 with only trace decay of 11.8 mV. Moreover, the assembled PEMWE with anode 350‐IrO2 catalyst outputs the current density up to 2 A cm−2 with only 1.84 V applied voltage, long‐term operation for 100 h without obvious performance degradation at 1 A cm−2.
Spectroscopy and Photochemistry of [Al, N, C, O, H]: Connectivity to Aluminium‐Bearing Species in the Universe
Authors: Wang Lina , Jiang Xin , Sun Beibei , Trabelsi Tarek , Francisco Joseph S. , Zeng Xiaoqing , Zhou Mingfei 
Published: May 2024

AbstractAluminium is one of the most abundant metals in the universe and impacts the evolution of various astrophysical environments. Currently detected Al‐bearing molecules represent only a small fraction of the aluminium budget, suggesting that aluminium may reside in other species. AlO and AlOH molecules are abundant in the oxygen‐rich supergiant stars such as VY Canis Majoris, a stellar molecular factory with 60+ molecules including the prebiotic NC‐bearing species. Additional Al‐bearing molecules with N, C, O, and H may form in O‐rich environments with radiation‐accelerated chemistry. Here, we present spectroscopic identification of novel aluminium‐bearing molecules composed of [Al, N, C, O, H] and [Al, N, C, O] from the reactions of Al atoms and HNCO in solid argon matrix, which are potential Al‐bearing molecules in space. Photoinduced transformations among six [Al, N, C, O, H] isomers and three [Al, N, C, O] isomers, along with their dissociation reactions forming the known interstellar species, have been disclosed. These results provide new insight into the chemical network of astronomically detected Al‐bearing species in space.
Tetrazole‐Functionalized Organoboranes Exhibiting Dynamic Intramolecular N→B‐Coordination and Cyanide‐Selective Anion Binding
Authors: Schepper Jonas , Orthaber Andreas , Pammer Frank 
Published: May 2024

AbstractStarting from two different cyano‐functionalized organoboranes, we demonstrate that 1,3‐dipolar [3+2] azide‐nitrile cycloaddition can serve to generate libraries of alkyl‐tetrazole‐functionalized compounds capable of intramolecular N→B‐Lewis adduct formation. Due to the relatively low basicity of tetrazoles, structures can be generated that exhibit weak and labile N→B‐coordination. The reaction furnishes 1‐ and 2‐alkylated regio‐isomers that exhibit different effective Lewis‐acidities at the boron centers, and vary in their optical absorption and fluorescence properties. Indeed, we identified derivatives capable of selectively binding cyanide over fluoride, as confirmed by 11B NMR. This finding demonstrates the potentialities of this synthetic strategy to systematically fine‐tune the properties of lead structures that are of interest as chemical sensors.
Towards sustainable, direct printed, organic transistors with biocompatible copolymer gate dielectrics
Authors: Massey Roslyn , Song Xiaoyu , Ashoori Shiva , Guan Jingwen , Prakash Ravi 
Published: May 2024

AbstractWe have investigated the potential of three dielectric materials to meet the future demands of green dielectrics: Polycaprolactone (PCL) thermoplastic, polyvinyl alcohol (PVA)‐carrageenan (CAR) crosslinked biopolymer, and boron nitride nanotubes (BNNTs) as a nano additive in PVA. Metal–insulator–metal (MIM) capacitors and organic thin film transistors (OTFT) were built with bilayer dielectric stacks of PVA‐CAR, PVA‐PCL, and PVA‐BNNT materials to examine their electrical properties. The PVA‐CAR layer uses a cyclic freeze thaw process to crosslink PVA and CAR for superior mechanical and electrical properties to either material alone. The PVA‐CAR MIM capacitors showed a dielectric constant of 23, which was found to be consistent with the extracted OTFT gate dielectric characteristics. Of the OTFT devices tested, PVA‐CAR OTFT showed highest device currents at low applied biases and produced an ON/OFF ratio of 104–105, both values were highest amongst the tested gate dielectrics. This material is therefore extremely promising for green electronics. The PVA‐PCL OTFT had very low leakage current and beneficial hydrophilic properties with comparable electrical properties to the commonly used organic material polytetrafluoroethylene. PVA‐BNNT MIM capacitors showed a low dielectric constant of 0.7, and the high resistivity makes this a promising material for shielding or substrates in high frequency applications. All three materials have the potential to fulfil different niches in a sustainable electronics future.
Association of transportation noise with cardiovascular diseases
Authors: Shah Badar ud Din , Raj Rohan , Kaur Parvinder , Karim Ali , Bansari Raveena Bai , Mehmoodi Amin , Malik Jahanzeb 
Published: May 2024

AbstractThis comprehensive article delves into the intricate and multifaceted issue of noise pollution, shedding light on its diverse sources, profound health implications, and the economic burden it imposes on societies. Noise pollution is an increasingly prevalent environmental challenge, impacting millions of people worldwide, often without their full awareness of its adverse effects. Drawing from a wealth of scientific research, the article underscores the well‐established links between noise pollution and a spectrum of health issues, including cardiovascular diseases, sleep disturbances, and psychological stress. While exploring the sources and consequences of noise pollution, the article highlights the urgent need for a holistic and collaborative approach to mitigate its impact. This entails a combination of regulatory measures, technological innovations, urban planning strategies, and public education campaigns. It is increasingly evident that the detrimental effects of noise pollution extend beyond physical health, encompassing mental and social well‐being. The article also addresses the synergistic relationship between noise pollution and other environmental stressors, emphasizing the importance of considering noise in conjunction with factors like air pollution and access to green spaces. It examines the potential of green spaces to mitigate the effects of noise pollution and enhance overall health.
Roles of myosin 1e and the actin cytoskeleton in kidney functions and familial kidney disease
Authors: Liu Pei‐Ju , Sayeeda Kazi , Zhuang Cindy , Krendel Mira 
Published: May 2024

AbstractMammalian kidneys are responsible for removing metabolic waste and maintaining fluid and electrolyte homeostasis via selective filtration. One of the proteins closely linked to selective renal filtration is myosin 1e (Myo1e), an actin‐dependent molecular motor found in the specialized kidney epithelial cells involved in the assembly and maintenance of the renal filter. Point mutations in the gene encoding Myo1e, MYO1E, have been linked to familial kidney disease, and Myo1e knockout in mice leads to the disruption of selective filtration. In this review, we discuss the role of the actin cytoskeleton in renal filtration, the known and hypothesized functions of Myo1e, and the possible explanations for the impact of MYO1E mutations on renal function.
Statin use and risks of breast cancer recurrence and mortality
Authors: Guo Hanbing , Malone Kathleen E. , Heckbert Susan R. , Li Christopher I. 
Published: May 2024

AbstractBackgroundPreclinical evidence suggests improved breast cancer survival associated with statin use, but findings from observational studies are conflicting and remain inconclusive. The objective of this study was to assess the association between statin use after cancer diagnosis and cancer outcomes among breast cancer patients.MethodsIn this retrospective cohort study, 38,858 women aged ≥66 years who were diagnosed with localized and regional stage breast cancer from 2008 through 2017 were identified from the linked Surveillance, Epidemiology, and End Results Medicare database. Statin use was ascertained from Medicare Part D pharmacy claims data. Multivariable Cox proportional hazards models were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) for the association between post‐diagnosis statin use and risks of breast cancer recurrence and breast cancer–specific mortality.ResultsOver a median follow‐up of 2.9 years for recurrence and 3.7 years for mortality, 1446 women experienced a recurrence, and 2215 died from breast cancer. The mean duration of post‐diagnosis statin use was 2.2 years. Statin use post‐diagnosis was not associated with recurrence risk (HR, 1.05; 95% CI, 0.91–1.21), but was associated with a reduced risk of cancer‐specific mortality (HR, 0.85; 95% CI, 0.75–0.96). The reduction was more pronounced in women with hormone receptor–positive/human epidermal growth factor receptor 2–negative breast cancer (HR, 0.71; 95% CI, 0.57–0.88).ConclusionsThese findings suggest that post‐diagnosis statin use is associated with improved cancer‐specific survival in women with breast cancer and should be confirmed in randomized trials of statin therapy in breast cancer patients.