bluuebunny/crossref_metadata_2025_split huggingface dataset:
Exploring mental health in veterinary students: common stressors and effective coping strategies: a narrative review
Authors: Islam Rahib K. , Cobb Emily K. , McCowan Hannah K. , Watson Kylie , Bhattacharya Kaustuv , Chandra Anjali , Mohiuddin Warda , Gruszynski Karen , Wilkerson Amanda H. , Dascanio John J. , Davis Robert E. , Nahar Vinayak K. 
Published: February 2025

IntroductionVeterinary students face significant challenges impacting their mental health and wellbeing. The rigorous academic curriculum, high expectations, and demanding clinical training create an environment of intense pressure and constant stress. This review explores the demographic and psychosocial variables influencing mental health outcomes, highlighting common stressors and coping strategies.MethodsA systematic literature search was conducted using PubMed, CAB Abstracts, and Google Scholar. Studies published up to 2021 involving veterinary students were included. Twenty-one peer-reviewed studies met the inclusion criteria. Demographic data, stressors, mental health measures, and coping strategies were extracted and analyzed. Studies focused on various mental health aspects, including stress, anxiety, depression, and coping mechanisms. The final selection was based on relevance, quality, and comprehensiveness.ResultsThe reviewed studies indicated that rigorous academic demands, high expectations, and clinical training contribute to elevated stress levels among veterinary students. Women reported higher levels of stress, anxiety, and depression compared to men, necessitating gender-specific interventions. Social support and relationship quality were crucial for mental wellbeing, with students in supportive environments experiencing lower stress. Effective coping strategies included exercise and social activities; whereas, harmful behaviors like substance misuse exacerbated mental health issues. Despite using mental health services, barriers such as stigma and lack of awareness hindered access for some students.ConclusionThe findings underscore the need for targeted support systems to enhance the mental health and resilience of veterinary students. Interventions to promote healthy coping mechanisms, reduce stigma, and improve access to mental health resources are essential. Veterinary schools should prioritize creating a supportive environment to ensure students can manage the demands of their profession while maintaining their mental health and wellbeing.
Exploring Antimycobacterial Potential: Safety Evaluation and Active Compound Isolation from Gymnopilus junonius
Authors: Didloff Jenske , Boukes Gerhardt J. , Nyambe Mutenta N. , Beukes Denzil R. , Lerata Mookho S. , Vilane Velile , Lee Michael , Govender Sharlene , van de Venter Maryna 
Published: February 2025

Background/Objectives: Tuberculosis remains a major public health crisis, and it is imperative to search for new antimycobacterial drugs. Natural products, including medicinal macrofungi, have been used as sources for the discovery of pharmaceuticals; however, research on their antimycobacterial activity remains limited. This study aimed to isolate and identify the bioactive compound responsible for antimycobacterial activity, thereby expanding on the limited knowledge regarding the antimicrobial activity and bioactive compounds present in Gymnopilus junonius. Methods: Bioassay-guided fractionation using column chromatography and preparative thin-layer chromatography were employed to isolate the active compound. Antimycobacterial activity against Mycobacterium tuberculosis H37 was assessed using a resazurin microplate assay (REMA). The chemical structure was determined by 1H nuclear magnetic resonance (NMR) spectroscopy, heteronuclear single quantum coherence (HSQC) spectroscopy, heteronuclear multiple bond correlation (HMBC) spectroscopy, and high-resolution electrospray ionization mass (HR-ESI-MS) spectrometry. Transmission electron microscopy (TEM) was used to observe the ultrastructural changes in M. tuberculosis induced by the compound. Cytotoxicity was evaluated in African green monkey kidney cells (Vero), human liver cells (C3A), and zebrafish embryos/larvae. Results: Bioassay-guided fractionation led to the isolation of gymnopilene, which showed inhibitory activity against M. tuberculosis (MIC: 31.25 µg/mL). TEM analysis revealed that treatment with gymnopilene caused ultrastructural damage observed as the disruption and disintegration of the cell wall. While gymnopilene demonstrated cytotoxicity in Vero and C3A cells, no toxicity was observed in zebrafish embryos/larvae for the crude extract. Conclusions: This study highlights that macrofungi, such as G. junonius, could be a valuable resource of bioactive compounds.
The Potential Role of Intestinal Microbiota on the Intestine-Protective and Lipid-Lowering Effects of Berberine in Zebrafish (Danio rerio) Under High-Lipid Stress
Authors: Gao Chang , Wang Heng , Xue Xuan , Qi Lishun , Lin Yanfeng , Wang Lei 
Published: February 2025

Background: Berberine has extremely low oral bioavailability, but shows a potent lipid-lowering effect, indicating its potential role in regulating intestinal microbiota, which has not been investigated. Methods: In the present study, five experimental diets, a control diet (Con), a high-lipid diet (HL), and high-lipid·diets·supplemented with an antibiotic cocktail (HLA), berberine (HLB), or both (HLAB) were fed to zebrafish (Danio rerio) for 30 days. Results: The HLB group showed significantly greater weight gain and feed intake than the HLA and other groups, respectively (p < 0.05). Hepatic triglyceride (TG) and total cholesterol (TC) levels, lipogenesis, and proinflammatory cytokine gene expression were significantly upregulated by the high-lipid diet, but significantly downregulated by berberine supplementation. Conversely, the expression levels of intestinal and/or hepatic farnesoid X receptor (fxr), Takeda G protein-coupled receptor 5 (tgr5), lipolysis genes, and zonula occludens 1 (zo1) exhibited the opposite trend. Compared with the HLB group, the HLAB group displayed significantly greater hepatic TG content and proinflammatory cytokine expression, but significantly lower intestinal bile salt hydrolase (BSH) activity and intestinal and/or hepatic fxr and tgr5 expression levels. The HL treatment decreased the abundance of certain probiotic bacteria (e.g., Microbacterium, Cetobacterium, and Gemmobacter) and significantly increased the pathways involved in cytochrome P450, p53 signaling, and ATP-binding cassette (ABC) transporters. The HLB group increased some probiotic bacteria abundance, particularly BSH-producing bacteria (e.g., Escherichia Shigella). Compared with the HLB group, the abundance of BSH-producing bacteria (e.g., Bifidobacterium and Enterococcus) and pathways related to Notch signaling and Wnt signaling were reduced in the HLAB group. Conclusions: This study revealed that berberine’s lipid-lowering and intestine-protective effects are closely related to the intestinal microbiota, especially BSH-producing bacteria.
Exploring Viscoelasticity: An Outreach Workshop for Middle and High School Students
Authors: Kardashina Tatiana , Pallarez Jessica A. , Talipov Marat R. , Serrano Elba E. , Drach Borys 
Published: February 2025

ABSTRACT
Engaging students in hands-on activities and providing out-of-school experiences have been shown to improve academic performance and spark interest in science. Our interdisciplinary team developed a workshop for middle and high school students as part of a summer program at a Hispanic-serving institution in southern New Mexico. The goal was to foster interest and readiness for science, technology, engineering, and mathematics careers and college entry. The workshop introduced students to viscoelasticity, a key concept in biophysics that describes the mechanical behavior of biological tissues, which is vital for understanding their structural and functional properties under various physical forces and conditions. The curriculum included a presentation, a discussion linking mechanical properties with biology, and hands-on experiments that demonstrated viscoelastic principles. Pre- and postworkshop surveys assessed students’ experiences and understanding of the material. Analysis revealed that students could relate the concepts to their daily lives, gained a basic understanding of mechanical properties, and found at least one experiment enjoyable and interesting.
A ChatGPT-Assisted Reading Protocol for Undergraduate Research Students
Authors: Sambar Marcus , Vázquez Gonzalo R. , Vázquez Anne V. , Vázquez Frank X. 
Published: February 2025

ABSTRACT
A major challenge for undergraduate students is reading scientific literature. This is especially true in biophysics, where many of the concepts may not have been covered in undergraduate courses. Students can become overwhelmed, which may lead to less overall engagement with the scientific literature. In response, we have developed a guided reading protocol that combines prereading strategies, structured note-taking, and ChatGPT to help students clarify unfamiliar concepts in an interactive way. To test the protocol, participants in this study were given an initial survey to determine their experience with reading scientific literature. After this, they were given an abridged biophysics paper and the protocol. The ChatGPT transcripts were analyzed by using open coding, and the students were given a poststudy survey. We found that most students did not appear to regularly engage with the literature, possibly because of content barriers they encountered. Analyzing their transcripts, we observed that students asked for definitions, explanations, summaries, and simplifications. Overall, students reported that using ChatGPT was a positive experience and that they expected to use ChatGPT in the future. From this work, we expect that this new protocol may be a way to keep novice students from becoming discouraged when reading scientific papers and keep them engaged with the current literature.
Automatización de la Justicia: ¿Puede un Algoritmo Reemplazar a un Juez?
Authors: Valladolid Mera Juan Carlos , Muñoa Vidal Tania , Véliz Valencia Yolange Dioclesiana 
Published: February 2025

El uso de las Tecnologías de Información y Comunicación (TIC), y los algoritmos, se imponen hoy en lo que a gobernanza digital respecta, razón por la cual el presente artículo aborda esta problemática focalizándose en términos de administración de justicia, con el objetivo de analizar las implicaciones éticas y legales de que un algoritmo reemplace a un juez en la toma de decisiones judiciales. La investigación se desarrolló bajo un enfoque cualitativo, con apoyo en la recolección de datos que consistió en la revisión de literatura o estado del arte, y análisis jurídico comparado. Los resultados señalan el riesgo de vulnerar derechos y principios procesales fundamentales como el de tutela judicial efectiva, el debido proceso y el principio de igualdad cuando se utiliza la IA en el poder judicial. De este modo, se obtuvieron como conclusiones que, a pesar de los beneficios de la implementación de algoritmos en los procesos judiciales, estos deben ser tomados como herramientas de agilización y no como un reemplazo directo, esto debido a la racionalidad que exige el papel del juez en la impartición de justicia y la propia humanización que axiológicamente caracteriza la misma y que bajo ningún concepto debe tergiversarse.
Increasing Utilization of Standardized Tools for Measurement-Based Care in the Management of Generalized Anxiety Disorder
Authors: Azhar Erum , Fatima Hira , Umer Mudasir , Afridi Asif Khan , Arif Mobeena , Barrera Trajan , Patel Feroza , Waheed Abdul 
Published: February 2025

ABSTRACT

Introduction
Generalized anxiety disorder (GAD) is a common mental health condition encountered in primary care settings. GAD screening, diagnosis, and management are challenging, among other issues that capture the attention of primary care physicians (PCPs). Measurement-based care (MBC) involves the systematic assessment of patients’ symptoms and treatment progress using standardized tools. Generalized Anxiety Disorder 7-Item (GAD-7) is a well-known screening and symptom-monitoring tool for GAD. It quantifies subjective symptoms objectively by measuring the patient’s anxiety level. We aimed to increase utilization of GAD-7 in outpatient clinics to improve diagnosis and management of GAD through educational interventions and by educating PCPs to access the GAD-7 tool in the EPIC electronic medical record (EMR) with ease.

Methods
This study employed a quasi-experimental interrupted time series design over 12 months. The intervention involved displaying posters educating family physicians on accessing GAD-7 screening tools in EMR and using smart phrases to document GAD-7 results in two outpatient family medicine clinics. SlicerDicer measured total anxiety encounters and GAD-7 utilization 3 months before and 9 months after intervention. Statistical process control was used, and control charts were created using the statistical software JMP Pro-16. A Poisson regression model was used to detect statistically significant differences using statistical software SAS 9.4.

Results
GAD-7 utilization increased from 4.5 in the preintervention period to 20.5 in the postintervention period. There was a significant increase in GAD-7 utilization over time after implementing our QI intervention. The control chart phase analysis showed a shift in the process with an increase in the average rate of GAD-7 utilization from 11.5 per 100 encounters per week in the preintervention phase to an average of 35.8 per 100 encounters per week postintervention phase. The effect was sustained over a year postintervention. The Poisson regression model also showed a 21% increase (p &lt; 0.0001) in the incidence rate ratio in the post-intervention period as compared with the preintervention.

Conclusion
Utilization of GAD-7 as an application of MBC improved with the implementation of a bundled intervention using quality improvement tools. Other programs may replicate this in their similar quality improvement endeavors.
Strengthening Reliability and Sustainability: Integrating Training Within Industry (TWI) in a Quality Improvement Collaborative
Authors: Borem Paulo , de Moura Rafaela Moraes , dos Santos Helena Barreto , Santos Guilherme Cesar Silva Dias , Bopsin Patrícia dos Santos , Ramos Beatriz , Gushken Andrea Keiko Fujinami , Braga Samara de Campos , Piusi Edileusa Novaes , Garzella Priscila Martini Bernardi , Baltazar Lais Silvestre Bizerra , Silva Karen Cristina da Conceição Dias , dos Santos Teilor Ricardo , Saavedra Bravo Marco Antonio , Petenate Ademir Jose , Cristalda Cristiane Maria Reis , Ue Luciana Yumi , de Barros Claudia Garcia , Vernal Sebastian ,   on behalf of the Saúde em Nossas Mãos collaborative study group
Published: February 2025

ABSTRACT

Introduction
Integrating process improvement tools into healthcare has shown promising results, yet the application of “training within industry” (TWI) still needs to be explored in this context. This study focuses on implementing job instruction (JI), one of the three components of TWI, within a large breakthrough series collaborative (BTS) in a middle-income country.

Methods
We evaluated the deployment of JI during a nationwide initiative aimed at reducing three critical healthcare-associated infections (HAIs)—central line–associated bloodstream infections (CLABSI), ventilator-associated pneumonia (VAP), and catheter-associated urinary tract infections (CAUTI)—across 189 Brazilian public intensive care units (ICUs). Our quality improvement (QI) project outlines the integration of JI to enhance the reliability of care bundles and empower frontline teams to reduce variation, one fundamental condition to maintain ongoing improvements.

Results
The implementation strategy included structured JI training for the hub’s leaders, which facilitated the gradual adoption and customization of JI and visual management techniques into daily ICU care. We detailed the four stages of JI training, the content of each session, and how they were incorporated into the existing BTS framework alongside visual management tools. The mean compliance to prevention bundles exceeded 90%, and the project results reached an overall reduction of 44%, 52%, and 54% for CLABSI, VAP, and CAUTI, respectively.

Conclusion
Our findings suggest that JI can be seamlessly integrated into routine QI activities. This structure promotes consistency in carrying out each aspect of care bundles, preventing HAI and strengthening patient safety.
A General Overview on the Medico Legal Provisions of Bharathiya Nyaya Sanhita 2023
Authors: Padmakumar Krishnankutty Nair  
Published: February 2025

The Bharatiya Nyaya Sanhita 2023 brought about very extensive alteration in the criminal justice system of India because it aims at overhauling the Indian Penal Code of 1860. This review article analyzes the new code from the medico-legal perspective, focusing on the provisions that might be of interest to medical and legal professionals. Specific parts of the act regarding consent, injury, criminal responsibility, medical negligence, sexual offenses, and other important areas are discussed in order to understand legislative purpose and real-life implications. Analyzing these provisions the article exposes how strategies of the healthcare delivery are interrelated with legal obligations, patients’ entitlements, professionalism, and the quest for justice in practice. Specifically, the goal of this review is to help practitioners, legal scholars, and policymakers as well as physicians be more aware and thus more cautious in the new legal environment that has emerged.
Фрагментарный роман: обязательные и факультативные характеристики жанра
Authors: Марьяновская Е.Л. 
Published: February 2025

Фрагментарный роман, представляющий собой единство формы и содержания как на уровне рассказа-фрагмента, так и на уровне всего единства, обладает обязательными и факультативными характеристиками, свойственными жанру. Единый заголовочный комплекс, тематический стержень, достаточно строгая последовательность эпизодов в единстве должны обязательно обнаруживаться при анализе. Факультативное наличие сквозного персонажа, а также единая композиционная организация каждого фрагмента, будучи вариативными характеристиками при наличии, лишь усиливают реализацию авторского замысла.
Having defined a fragmentary novel as a unity of form and content realized on all the levels, the author of the paper assumes that for the sake of the further successful study of the phenomenon it is necessary, first, to single out the nomenclature of semantic features characteristic of this genre, and second, to divide these features into obligatory and optional. Obligatory characteristics (both formal and meaningful) include a unifying title, which gathers the episodes of the fragmentary novel together foreshadowing the author’s message and communicative intention, a conceptual (thematic) pivot, a fixed order of the episodes in the unity. However, a similar composition of all the fragments functioning as independent stories and a pivotal character who may appear in a sequence of the stories are proved to be optional features. If present, they enhance the unity of the fragmentary novel on the level of form and content. Their absence doesn’t violate the unity either but involves the reader further into a more complicated process of restoring the missing fragments.
Ground-based Reconnaissance Observations of 21 Exoplanet Atmospheres with the Exoplanet Transmission Spectroscopy Imager
Authors: Oelkers Ryan J. , Schmidt Luke M. , Cook Erika , Limbach Mary Anne , DePoy D. L. , Marshall J. L. , Ardoin Jimmy , Barry Mitchell , Batteas Evan , Boone Alexandra , Conway Brant , Delgado Adrande Silvana , Dixon John D. , Gonzalez-Vega Enrique , Guajardo Alexandra , Holcomb Landon , Lambert Christian , Menon Shravan , Mishra Divya , Purcell Jacob , Reed Zachary , Sala Nathan , Siebersma Noah , Ton Nhu Ngoc , Walker Raenessa M. L. , Wang Z. Franklin , Webber Kaitlin 
Published: February 2025

Abstract
One of the most prolific methods of studying exoplanet atmospheres is transmission spectroscopy, which measures the difference between the depth of an exoplanet's transit signal at various wavelengths and attempts to correlate the depth changes to potential features in the exoplanet's atmosphere. Here we present reconnaissance observations of 21 exoplanet atmospheres measured with the Exoplanet Transmission Spectroscopy Imager (ETSI), a recently deployed spectrophotometer on the McDonald Observatory Otto Struve 2.1 m telescope. ETSI measurements are mostly free of systematics through the use of a novel observing technique called common-path multiband imaging (CMI), which has been shown to achieve photometric color precision on par with space-based observations (300 ppm or 0.03%). This work also describes the various statistical tests performed on the data to evaluate the efficacy of the CMI method and the ETSI instrument in combination. We find that none of the eight comparisons of exoplanet atmospheres measured with ETSI and other observatories (including the Hubble Space Telescope) provide evidence that the spectra are statistically dissimilar. These results suggest that ETSI can provide initial transmission spectroscopy observations for a fraction of the observational and monetary overhead previously required to detect an exoplanet's atmosphere. Ultimately these reconnaissance observations increase the number of planets with transmission spectroscopy measurements by ~10% and provide an immediate prioritization of 21 exoplanets for future follow-up with more precious observatories, such as the James Webb Space Telescope. The reconnaissance spectra are available through the Filtergraph visualization portal at the URL https://filtergraph.com/etsi/.
De la donnée contribuée à l’effet de réseau :modélisation du graphe de l’écologie territoriale
Authors: Loubière Vincent , Huraux Thomas , Veyrin-Forrer Luca , Wolff Yannick 
Published: February 2025

Orientée vers le déploiement massif de capteurs ou traceurs, l’optimisation et l’exploitation des flux (ressources, énergie, agents …), la smart city s’incarne de façon descendante et techniciste au cœur des dynamiques de grandes plateformes qui tendent à la centralisation. Cet article propose une approche ancrée sur le terrain, pour penser « par le bas » l’alternative d’un principe de « donnée contribuée » capable de produire un graphe de l’écologie territoriale, commun du territoire circulaire. S’appuyant sur une expérimentation en cours sur le territoire de Plaine Commune en Ile-de-France, cet article décrit le déploiement opérationnel d’une plateforme numérique territorialisée capable de mobiliser l’effet de réseau à travers une démarche d’encapacitation systémique des acteurs, afin de conduire une planification écologique ascendante. On s’écarte alors du smart citizen vers la notion d’empowered citizen.