bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hemangiopericytoma: long-term outcome revisited
Authors: Schiariti Marco , Goetz Pablo , El-Maghraby Hussien , Tailor Jignesh , Kitchen Neil 
Published: July 2010

Object
Hemangiopericytomas are rare tumors that behave aggressively with a high rate of local recurrence and distant metastases. With the aim of determining the outcome and response to various treatment modalities, a series of 39 patients who underwent microsurgical resection for primary meningeal hemangiopericytoma over a 24-year period is presented.

Methods
Patients with hemangiopericytoma were identified from histopathology records and their medical records were analyzed retrospectively by 2 independent reviewers to collect data on surgical treatment, adjuvant therapy, postoperative course, local or distant recurrence, and follow-up.

Results
Of the 39 patients, 19 were male and 20 were female. Mean patient age was 44.1 years. Thirty-four tumors were intracranial and 5 were spinal. The mean follow-up period was 123 months. Twenty-eight patients developed local recurrence. The recurrence rate at 1, 5, and 15 years was 3.5%, 46%, and 92%, respectively. Extraneural metastasis occurred in 8 patients (26%) at an average of 123 months after initial surgery. Recurrences and metastases were treated by surgical excision, external beam radiation therapy (EBRT), chemotherapy, and/or stereotactic radiosurgery. Adjuvant EBRT following initial surgery was found to extend the disease-free interval from 154 months to 254 months, although it did not prevent the development of metastasis. In those patients with EBRT and complete resection, the mean recurrence-free interval was found to be 126.3 months longer (p = 0.04) and overall survival 126 months longer than without EBRT. Furthermore, adjusting for resection, patients undergoing EBRT had 0.33 times increased risk of recurrence compared with those who did not (p = 0.03). A majority of patients remained able to live independently despite revision surgery for recurrence.

Conclusions
The mean follow-up of this patient series represents the longest follow-up duration published to date and demonstrates extended survival in a significant number of patients with hemangiopericytoma. Gross-total resection followed by adjuvant EBRT provides patients with the highest probability of an increased recurrence-free interval and overall survival. Prolonged survival justifies long-term follow-up and aggressive treatment of initial, recurrent, and metastatic disease.
The Impact of Treatment Modality on Infection-Related Hospitalization Rates in Peritoneal Dialysis and Hemodialysis Patients
Authors: Williams Victoria R. , Quinn Robert , Callery Sandra , Kiss Alex , Oliver Matthew J. 
Published: July 2010

Background and Objectives Infection is a major cause of morbidity and mortality in the dialysis population. This study compares the rates of infection-related hospitalization (IRH) in incident chronic dialysis patients initiating outpatient peritoneal dialysis (PD) and hemodialysis (HD). Methods and Patients This was a retrospective cohort study at the dialysis program of a tertiary-care center in Toronto, Canada. Incident chronic dialysis patients that were eligible for both PD and HD and started outpatient dialysis between 1 January 2004 and 31 August 2008 were included. Dialysis modality was assigned at the start of outpatient dialysis treatment. All hospital admissions were reviewed and incidence of IRH was compared between PD and HD using Poisson regression. Results Of 264 incident chronic dialysis patients, 168 (64%) were eligible for both treatment modalities: 71 (42%) started outpatient PD and 97 (58%) started outpatient HD. The unadjusted and adjusted incidence rate ratios (IRR) of IRH did not differ significantly between PD and HD: 1.23 [95% confidence interval (CI) 0.65 - 2.32, p = 0.37] and 1.14 (95% CI 0.58 - 2.23, p = 0.71) respectively. There was no difference between PD and HD in the risk of access loss (28% vs 35%, p = 0.73), modality change (22% vs 0%, p = 0.10), or death (17% vs 6%, p = 0.60) following hospitalization for infection. Patients starting outpatient treatment on PD versus HD were more likely to be hospitalized for peritonitis (IRR 3.20, 95% CI 1.16 - 9.09; p = 0.029) and there was a trend for fewer hospitalizations for bacteremia (IRR 0.19, 95% CI 0.028 - 1.30; p = 0.091). The risk of IRH did not differ between PD and HD in the subgroup of patients that received adequate predialysis care (IRR 1.16, 95% CI 0.59 - 2.27; p = 0.67) or when patients starting outpatient HD with a central venous catheter were excluded (IRR 1.52, 95% CI 0.53 - 4.37; p = 0.44). Conclusions Patients that initiate outpatient peritoneal dialysis do not have a significantly increased risk of infection-related hospitalization compared to those that initiate outpatient hemodialysis.
Building an Organizational Culture of Caring: Caring Perceptions Enhanced with Education
Authors: Glembocki Margaret M. , Dunn Karen S. 
Published: July 2010

Background:
This pilot study was undertaken to determine whether an educational intervention called Reigniting the Spirit of Caring (RSC) from Creative Healthcare Management would enhance perceptions of caring behaviors among nurses. A pretest/posttest within-subjects research design was used to evaluate the educational intervention.

Methods:
Investigators used the licensed RSC program as the educational intervention. This study included 36 registered nurses employed in one Midwestern hospital.

Results:
Statistical differences were found in the pretest and posttest measurement of nurses’ perceptions of caring behaviors.

Conclusion:
The RSC program can be used as an effective educational intervention to increase nurses’ perceptions of caring, and the Caring Assessment for the Caregiver tool can be used as an effective tool to measure nurses’ perceptions of caring behaviors.
Reliability of the IOLMaster in Measuring Corneal Power Changes After Hyperopic Photorefractive Keratectomy
Authors: Rosa Nicola , De Bernardo Maddalena , Borrelli Maria , Filosa Maria Luisa , Minutillo Emma , Lanza Michele 
Published: July 2010

Purpose:
To test the accuracy of the IOLMaster (Carl Zeiss Meditec) in detecting corneal power changes after hyperopic photorefractive keratectomy (PRK).

Methods:
Forty-five consecutive eyes that underwent hyperopic PRK with the SCHWIND ESIRIS excimer laser, ranging from +0.75 to +7.00 diopters (D) (mean: +3.84±1.56 D), were analyzed. Data included pre- and postoperative (1, 3, and 6 months) fogging refraction and automated keratometry (K). Statistical analysis was performed to determine the correlation between the changes in refraction at the corneal plane and the changes in keratometry.

Results:

The mean difference between the changes in refraction and the measured corneal changes was +0.27±1.19 D (range: −1.91 to +4.28 D) (
P
=.18) at 1 month; +0.56±0.97 D (range: −1.00 to +2.96 D) (
P
=.006) at 3 months; and +0.67±0.80 D (range: −0.73 to +2.31 D) (
P
=.00002) at 6 months. Based on these results, we suggest using the regression formula found at 6-month follow-up (y=0.8074 x + 0.092) to better calculate the effective corneal power. Comparison between the data obtained with IOLMaster measurements and equivalent K readings from the Holladay report obtained with the Pentacam (Oculus Optikgeräte GmbH) shows good agreement (R
2
=0.9).

Conclusions:
Automated keratometry provided by the IOLMaster underestimates the effective refractive changes after hyperopic PRK, and a correcting factor is needed to calculate the corneal power in these cases.
Refractive Stability of LASIK with the VISX 20/20 Excimer Laser vs ZB5M Phakic IOL Implantation in Patients with High Myopia (>−10.00 D): A 10-Year Retrospective Study
Authors: Rosman Mohamad , Alió Jorge L. , Ortiz Dolores , Pérez-Santonja Juan J. 
Published: July 2010

Purpose:
To compare the long-term outcomes of LASIK and ZB5M phakic intraocular lens implantation (PIOL) (Domilens) for high myopia (>−10.00 diopters [D]).

Methods:
This long-term (10 years) follow-up retrospective interventional case series study included 126 eyes that underwent LASIK and 52 eyes that underwent ZB5M angle-supported PIOL implantation. Both groups of eyes were similar in terms of preoperative spherical equivalent refraction (SE), corrected distance visual acuity (CDVA), and age.

Results:

Mean preoperative SE was −14.33 D in the LASIK group and −14.84 D in the PIOL group. At 10-year follow-up, mean postoperative SE was −1.47±2.00 D in the LASIK group and −1.01±1.36 D in the PIOL group (
P
=.21). In the LASIK group, 67% of eyes were within ±1.00 D of emmetropia at 2 years after surgery, compared to 42% at 10 years. In the PIOL group, 68% of eyes were within ±1.00 D of emmetropia 2 years after implantation compared to 53% at 10 years. In the LASIK group, 43.5% of eyes achieved UDVA of 20/40 or better 10 years after surgery compared to 67.9% in the PIOL group (
P
=.02).

Conclusions:
The ZB5M angle-supported PIOL was shown to have better predictability and stability compared to LASIK over 10 years. However, reductions in endothelial cell count over time were observed in eyes with PIOLs.
Descemet’s Membrane Detachment Following Phacoemulsification
Authors: Sukhija Jaspreet , Ram Jagat , Kaushik Sushmita , Gupta Amod 
Published: July 2010

Background and Objective:
To determine the management options and the indications for surgical intervention in Descemet’s membrane detachment (DMD) after phacoemulsification.

Patients and Methods:
Clinical records of 11 consecutive eyes (11 patients) with DMD were reviewed. All cases had undergone phacoemulsification with posterior chamber intraocular lens implantation. Patients with DMD involving one-third or more of the cornea were analyzed.

Results:
All patients underwent clear corneal phacoemulsification. In three cases where the detachment was recognized intraoperatively, perfluoropropane gas was injected. Eight eyes (8 cases) had unexpected corneal edema detected as DMD postoperatively and managed by injecting perfluoropropane gas into the anterior chamber. Three eyes that required repeated surgical intervention postoperatively had more than 50% corneal involvement with significant separation of the membrane from the stroma and curling or folding of the membrane. At last follow-up, 10 eyes retained clear corneas and one had residual DMD not involving visual axis. All 11 eyes had best-corrected visual acuity of better than 6/12.

Conclusion:
DMD should be suspected in patients showing unexpected corneal edema postoperatively who have undergone uneventful phacoemulsification and be treated in a timely manner. Surgical intervention is recommended in cases with significant separation of the membrane from stroma and curling or folding of the Descemet’s membrane.
ROLE AND TIMING OF HEMATOPOIETIC CELL TRANSPLANTATION FOR MYELODYSPLASTIC SYNDROME
Authors: Field Teresa L , Anasetti Claudio 
Published: July 2010

Allogeneic hematopoietic cell transplantation (HCT) is the only curative treatment for patients with myelodysplastic syndromes (MDS). Most patients with MDS are older than 60 years and age-associated morbidities limit the patients’ options for curative transplant therapy. Since the development of conditioning regimens with reduced toxicity, the age limitations for HCT have waned for those patients with good performance status. This review will discuss the role of HCT for MDS based on prognostic features, the optimal timing of HCT, and outcomes based on patient age.
A longitudinal study to explain the pain‐depression link in older adults with osteoarthritis
Authors: Hawker Gillian A. , Gignac Monique A. M. , Badley Elizabeth , Davis Aileen M. , French Melissa R. , Li Ye , Perruccio Anthony V. , Power J. Denise , Sale Joanna , Lou Wendy 
Published: July 2010

AbstractObjectiveTo evaluate whether osteoarthritis (OA) pain determines depressed mood, taking into consideration fatigue and disability and controlling for other factors.MethodsIn a community cohort with hip/knee OA, telephone interviews assessed OA pain and disability (Western Ontario and McMaster Universities Osteoarthritis Index [WOMAC]), fatigue (Multidimensional Fatigue Symptom Inventory), depressed mood (Center for Epidemiologic Studies Depression Scale), and covariates (demographics, self‐rated health, comorbidity, pain coping, pain catastrophizing, and social support) at 3 time points over 2 years. Drawing on previous research, a path model was developed to test the interrelationships among the key concepts (pain, depression, fatigue, disability) over time, controlling for covariates.ResultsThe baseline mean age was 75.4 years; 78.5% of the subjects were women, 37.2% were living alone, and 15.5% had ≥3 comorbid conditions. WOMAC scores indicated moderate OA symptoms and disability. From the final model with 529 subjects, adjusting for covariates, we found that current OA pain strongly predicted future fatigue and disability (both short and long term), that fatigue and disability in turn predicted future depressed mood, that depressed mood and fatigue were interrelated such that depressed mood exacerbated fatigue and vice versa, and that fatigue and disability, but not depressed mood, led to worsening of OA pain.ConclusionControlling for other factors, OA pain determined subsequent depressed mood through its effect on fatigue and disability. These effects led to worsening of pain and disability over time. These results support the need for improved pain management in OA to prevent or attenuate the downstream effects of pain on disability and mood.
Tuning the Composition and Nanostructure of Pt/Ir Films via Anodized Aluminum Oxide Templated Atomic Layer Deposition
Authors: Comstock David J. , Christensen Steven T. , Elam Jeffrey W. , Pellin Michael J. , Hersam Mark C. 
Published: July 2010

AbstractNanostructured metal films have been widely studied for their roles in sensing, catalysis, and energy storage. In this work, the synthesis of compositionally controlled and nanostructured Pt/Ir films by atomic layer deposition (ALD) into porous anodized aluminum oxide templates is demonstrated. Templated ALD provides advantages over alternative synthesis techniques, including improved film uniformity and conformality as well as atomic‐scale control over morphology and composition. Nanostructured Pt ALD films are demonstrated with morphological control provided by the Pt precursor exposure time and the number of ALD cycles. With these approaches, Pt films with enhanced surface areas, as characterized by roughness factors as large as 310, are reproducibly synthesized. Additionally, nanostructured PtIr alloy films of controlled composition and morphology are demonstrated by templated ALD, with compositions varying systematically from pure Pt to pure Ir. Lastly, the application of nanostructured Pt films to electrochemical sensing applications is demonstrated by the non‐enzymatic sensing of glucose.
Piecewise linear relaxation of bilinear programs using bivariate partitioning
Authors: Hasan M. M. Faruque , Karimi I.A. 
Published: July 2010

AbstractSeveral operational and synthesis problems of practical interest involve bilinear terms. Commercial global solvers such as BARON appear ineffective at solving some of these problems. Although recent literature has shown the potential of piecewise linear relaxation via ab initio partitioning of variables for such problems, several issues such as how many and which variables to partition, which partitioning scheme(s) and relaxation model(s) to use, placement of grid points, etc., need detailed investigation. To this end, we present a detailed numerical comparison of univariate and bivariate partitioning schemes. We compare several models for the two schemes based on different formulations such as incremental cost (IC), convex combination (CC), and special ordered sets (SOS). Our evaluation using four process synthesis problems shows a formulation using SOS1 variables to perform the best for both partitioning schemes. It also points to the potential usefulness of a 2‐segment bivariate partitioning scheme for the global optimization of bilinear programs. We also prove some simple results on the number and selection of partitioned variables and the advantage of uniform placement of grid points (identical segment lengths for partitioning). © 2009 American Institute of Chemical Engineers AIChE J, 2010
Classifying the fluidization and segregation behavior of binary mixtures using particle size and density ratios
Authors: Rao Akhil , Curtis Jennifer S. , Hancock Bruno C. , Wassgren Carl 
Published: July 2010

AbstractExperimental investigations show that fluidized binary mixtures exhibit varied pressure drop profiles and segregation patterns, depending on the level of disparity due to size and/or density differences. In this study, different mixture types are mapped on a graph of density versus size ratios. It is found that the ratio of the minimum fluidization velocities of individual components can be used to categorize these mixtures. A simple correlation is developed to compute the ratio of the minimum fluidization velocities based on the density and size ratios. Categorizing the binary mixtures in this manner gives a qualitative understanding of how the different mixtures behave on fluidization. © 2010 American Institute of Chemical Engineers AIChE J, 2011
Conceptual design of distillation processes for mixtures with distillation boundaries: I. Computational assessment of split feasibility
Authors: Brüggemann Stefan , Marquardt Wolfgang 
Published: July 2010

AbstractGeometric design methods for the conceptual design of azeotropic distillation processes are fast and efficient tools for the economic screening of different process alternatives. This two‐part series presents a fully automated conceptual design method for finding an optimal recycle policy for the separation of mixtures with distillation boundaries. It does not require visualization and graphical inspection of residue curve or pinch maps and is, hence, not limited to ternary mixtures. The first part introduces a fully computational geometric split feasibility test based on bifurcation analysis. This bifurcation‐based feasibility test can be used as a valuable stand‐alone tool for the assessment of different separation options. It is also one of the core elements of the recycle optimization discussed in the second part of this series. © 2010 American Institute of Chemical Engineers AIChE J, 2011
Nanostrukturierte Kohlenstoffmaterialien aus molekularen Vorstufen
Authors: Hoheisel Tobias N. , Schrettl Stephen , Szilluweit Ruth , Frauenrath Holger 
Published: July 2010

AbstractNanostrukturierte Kohlenstoffmaterialien, also Kohlenstoffe, die eine charakteristische Größe im Nanometerbereich sowie eine eventuell funktionalisierte Oberfläche aufweisen, spielen eine zentrale Rolle in vielen wissenschaftlichen Disziplinen. Erste Anwendungen finden derartige Materialien dabei unter anderem in Bereichen wie der Erforschung alternativer Energiequellen, leistungsfähiger Energiespeichermaterialien, nachhaltiger chemischer Technologien oder auch im Gebiet der organisch‐elektronischen Materialien. Des Weiteren könnten diese Materialien mögliche Ansätze und Lösungen bieten, um dem voranschreitenden Verbrauch fossiler Brennstoffe und somit dem Klimawandel entgegenzusteuern. Ferner könnten nanostrukturierte Kohlenstoffmaterialien auch auf dem Gebiet der Mikroelektronik einen Durchbruch herbeiführen. Allerdings ist die Entwicklung neuer Herstellungsverfahren für kohlenstoffreiche Materialien unabdingbar, die unter anderem Kontrolle über die Oberflächenchemie, die mesoskopische Struktur und die Mikrostruktur ermöglichen. Ein vielversprechender Ansatz ist dabei die Synthese dieser Materialien aus wohldefinierten molekularen Vorstufen.
Zum Wirkungsbereich der chemischen Synthese: Aufbau einer Minipipeline in einem akademischen Labor
Authors: Wilson Rebecca M. , Danishefsky Samuel J. 
Published: July 2010

AbstractIn dieser Retrospektive erinnern wir an einige ausgewählte Beispiele für die Synergie zwischen der sehr anspruchsvollen chemischen Synthese und der Identifizierung von neuen vielversprechenden Wirkstoff‐Kandidaten als potenzielle Pharmazeutika. Die Weiterentwicklung von oft niedermolekularen Zielverbindungen zu solchen, deren Größe normalerweise mit biologischen Wirkstoffen assoziiert ist, wird ebenfalls dargelegt.
Preclinical and clinical investigation of a CCR5 antagonist, AZD5672, in patients with rheumatoid arthritis receiving methotrexate
Authors: Gerlag Daniëlle M. , Hollis Sally , Layton Mark , Vencovský Jiří , Szekanecz Zoltán , Braddock Martin , Tak Paul P. ,   ESCAPE Study Group
Published: July 2010

AbstractObjectiveTo investigate both the preclinical effects of blocking the chemokine receptor CCR5 and the clinical effects of this approach on the signs and symptoms of rheumatoid arthritis (RA) in patients with active disease.MethodsPreclinical evaluations of AZD5672, a small‐molecule antagonist of CCR5, were performed, including studies of ligand binding and chemotaxis. The pharmacokinetics of AZD5672 were assessed in both single‐ and multiple‐dose studies in healthy volunteers. A randomized, placebo‐controlled, phase IIb study was conducted in patients with active RA receiving methotrexate. Treatment arms were AZD5672 (20, 50, 100, or 150 mg orally, once daily), matched placebo, or open‐label etanercept (50 mg subcutaneously, once weekly). The primary end point was the proportion of patients achieving a 20% improvement response on the American College of Rheumatology improvement criteria (ACR20) at week 12. Secondary end points included the ACR20 over time, as well as 50% (ACR50) and 70% (ACR70) improvement responses, changes in individual components of the ACR improvement criteria, and disease activity measured with the Disease Activity Score based on the 28‐joint count.ResultsAZD5672 was a highly potent and selective antagonist of CCR5, displaying nonproportional steady‐state pharmacokinetics while inhibiting internalization of CCR5 in an ex vivo macrophage inflammatory protein 1β stimulation assay in which AZD5672 was evaluated over the 20–150‐mg dose range. In the phase IIb study testing this dose range in patients with RA (n = 371 patients randomized to received treatment), AZD5672 was generally well tolerated, with no unexpected adverse events. There was no statistically significant difference in the proportion of patients achieving an ACR20 response at week 12 between those receiving any dose of AZD5672 and those receiving placebo; etanercept was significantly more efficacious than AZD5672 and placebo.ConclusionDespite a clear rationale for targeting CCR5, this clinical study showed that AZD5672, administered orally, did not have any clinical benefit, suggesting that CCR5 antagonism alone is unlikely to be a viable therapeutic strategy in RA.