bluuebunny/crossref_metadata_2025_split huggingface dataset:
She is the boss: determinants of legitimacy of women as family business leaders
Authors: Lapeira Maria , Samara Georges 
Published: February 2025

PurposeWomen often face multiple challenges when they are involved in the business. Their situation is even more complex in the family business setting, where multiple family and non-family stakeholders may challenge their legitimacy as a business leader. However, while some women remain invisible, others are able to become legitimate leaders in the family business. This study explores the circumstances that enable women to become legitimate and successful leaders in family businesses embedded in patriarchal contexts.Design/methodology/approachConsidering that our research question is aimed at exploring the determinants of legitimacy of women in the family business, we employed a qualitative research approach using multiple case studies. Data were collected through interviews, secondary sources (internal documents and websites), conversations and observations. Semi-structured interviews were conducted separately with three or four respondents from each firm.FindingsThis study finds that women can have a legitimate “professional” role when they are involved in the business early, when they have outside work experience, when they are provided with equal opportunities for learning and development compared to their male siblings and when they are provided with adequate mentoring opportunities from women role models.Originality/valueThis study makes several contributions to the study of gender dynamics in family businesses by unpacking the determinants of women’s legitimacy as leaders in family businesses. This paper also expands on the typologies that Curimbaba (2002) provides, while the typology identifies the different roles that women can play in a family business (i.e. invisible, anchors or professionals), it does not clearly delineate why some women are considered legitimate professional leaders, while others are treated as invisible or anchors. Additionally, this study offers novel insights coming from a patriarchal non-developed context, Colombia.
Business transformation processes and Society 5.0: opportunities and challenges
Authors: Silva Daniela C. , Ferreira Fernando A.F. , Milici Alexandra , Ferreira João J.M. , Ferreira Neuza C.M.Q.F. 
Published: February 2025

PurposeIn light of the challenges and opportunities posed by globalization and technological advancements, this study aims to develop a decision-support system to assist companies in identifying, structuring and prioritizing variables influencing their transformation and adaptation processes to Society 5.0.Design/methodology/approachThe research employs a methodological approach focused on knowledge creation through expert discussions involving diverse backgrounds. Cognitive mapping and interpretive structural modeling (ISM) guide the process, allowing for the integration of subjective elements into the analysis system while ensuring objectivity through ISM. The methodology involves structuring the decision problem, identifying and ranking key factors and evaluating their cause-and-effect relationships.FindingsThe analysis underscores the significance of technology and external factors compared to other areas of interest within the model. Consequently, the study emphasizes the necessity for companies to pay special attention to these types of factors during their transformation processes.Research limitations/implicationsWhile the study provides valuable insights, the reliance on expert discussions may introduce biases or overlook certain perspectives. Additionally, the findings may not be universally applicable and may require customization based on specific organizational contexts or industries. However, the proposed decision-support system offers a practical tool for companies seeking successful adaptation to Society 5.0.Originality/valueThis study provides a novel approach to addressing the challenges posed by globalization and technological advancements. It presents a valuable resource for organizations striving to adapt effectively in the evolving socioeconomic landscape.
Steady state creep of the silver-tin TLP interconnections of power modules
Authors: Gharaibeh Mohammad A. , Feisst Markus , Wilde Jürgen 
Published: February 2025

PurposeThis paper aims to investigate the steady-state creep of the multilayer Silver-Tin transient liquid phase (AgSn-TLP) interconnects of the power modules using experiments and constitutive modeling.Design/methodology/approachA series of engineered creep tests is executed at different temperatures and stress levels to produce creep strain versus time data. Accordingly, steady-state creep parameters are acquired through nonlinear regressions. Two steady-state creep relations, including hyperbolic sine and power laws, are created, and validated with measured data. Afterwards, numerical studies are executed to examine the thermomechanical response of the AgSn-TLP interconnects compared to other bond materials.FindingsGenerally, the AgSn- TLP interconnections showed higher resistance to the accumulation of creep strains, indicating their potential to perform efficiently in high temperature applications.Originality/valueThis paper models the steady-state creep response of the silver-tin TLP bonds using hyperbolic sine and power laws. These models are important for stress and strain analysis using numerical simulations.
Effect of process parameters on wire-arc direct energy deposited Inconel 718 superalloy
Authors: Kumar Parveen , Raj Singh Ratnesh Kumar , Sharma Satish Kumar 
Published: February 2025

Purpose
Owing to its leverage of high deposition rate, the wire arc additive manufacturing (WAAM) process is being adopted for the development of IN718 alloy used in aerospace, transportation and energy sectors. The purpose of this study is to observe the effect of process parameters on the mechanical properties of the IN718 superalloy.

Design/methodology/approach
This study emphasizes the effect of WAAM process parameters on mechanical and metallurgical properties of developed multilayer structures of IN718 alloy by means of orthogonally designed experiments.

Findings
The results show that high current and voltage settings, combined with low welding speed, provide increase bead width, height and effective wall area, while resulting in decrease surface waviness, hardness and tensile properties. The scanning electron microscopy and energy dispersive spectroscopy results show the presence of secondary precipitates such as NbC and Ni3(Al, Ti) in low-heat samples, which improve the mechanical properties of the material. However, the presence of Laves phases deteriorates the mechanical properties in high-heat samples. The electron backscatter diffraction results confirmed the presence of more grain boundaries and highly textured surfaces in lower heat samples, which improves mechanical properties.

Originality/value
The effect of process parameters on the microstructural features and mechanical properties along with bead characteristic are studied in-depth and influence of each parameter are discussed.
CEO power and gender diversity in corporate boards: evidence from European companies
Authors: Sghaier Adnene 
Published: February 2025

Purpose
This study aims to examine the impact of CEO power and regulatory frameworks, particularly gender quotas, on board gender diversity. It explores how CEO power interacts with regulations to influence women’s representation on boards and assesses the role of female CEOs in this context.

Design/methodology/approach
This study uses a quantitative research approach, analyzing data from 2003 to 2023. It uses ordinary least squares regression and entropy balance to evaluate relationships between CEO power, regulatory stringency and board gender diversity. Instrumental variables and the two-step generalized method of moments are used to address endogeneity and ensure the robustness of the results.

Findings
The power of the CEO significantly enhances the diversity of board genders. Female CEOs also contribute to this, reinforcing the role model effect. While regulatory gender quotas boost diversity, they may result in “tokenism” once targets are reached. The synergy of CEO power and regulatory frameworks maximizes diversity, with female CEOs being most effective when supported by both quotas and CEO influence.

Practical implications
This study emphasizes the importance of powerful CEOs in promoting gender diversity, particularly when working in tandem with strong regulatory frameworks. It suggests that organizations take advantage of CEO influence and regulatory support to exceed quota compliance and foster a genuine diversity culture. Female leadership plays a key role in improving board diversity.

Originality/value
This research uniquely demonstrates the combined effect of CEO power and regulatory frameworks on board diversity, highlighting the critical role of female CEOs. It offers new insights into how organizational and regulatory dynamics interact to advance gender equality in corporate governance.
Drivers of phenological transitions in the seedling life stage
Authors: Slate Mandy L. , Sporbert Maria , Hensen Isabell , Hierro Jose L. , Korell Lotte , Larios Loralee , Nagy Dávid U. , Pearson Dean E. , Waller Lauren , Wolf Felicitas , Rosche Christoph 
Published: February 2025

Abstract

Plant functional ecology research has primarily focused on juvenile and adult plants even though regeneration from seed can be the most consequential life‐history bottleneck with cascading influence on later stages of growth and reproduction. Understandings of relationships among phenology, morphology and growth‐related functional traits have improved our knowledge of plant life‐history strategies and adaptive responses to changing climate. However, whether relationships among phenological and morpho‐physiological traits exist during plant regeneration is unknown. We also lack understanding of the relative importance of these relationships compared with those of regeneration phenology with other factors like plant phylogeny, geographic location and whether a species is native or non‐native to the location.

To better understand these gaps in knowledge, we evaluated three phenological traits (days to germination, first and third true leaves) and six morpho‐physiological traits (seed mass, relative growth rate, root elongation rate, root: shoot ratio, specific leaf area and seedling C:N) associated with regeneration for 131 forb species from six globally distributed grasslands.

Morpho‐physiological traits showed several significant correlations with phenological traits. Boosted regression trees revealed that their relative importance in predicting phenological traits varied among the three phenological stages (34%–51%). Interestingly, the relative importance of morpho‐physiological traits on the phenological stages was comparable to that of phylogeny (36%–46%). In general, species with faster phenologies produced seedlings that grew faster. The influence of geographic location on phenological traits was strongest at germination (29%) and decreased (8%–15%) at later phenological stages. Native versus non‐native origin had little to no impact (0%–2%) on regeneration phenology.

Strong relationships between days to germination and geographic location indicate signatures of local adaptation in the earliest life stages. Similar morpho‐physiological trait values between native and non‐native forbs imply that trait matching may be essential for non‐native establishment. While associations between phenological and morpho‐physiological traits during regeneration have not been previously recognized, our results suggest that these are complex and variable across plant regeneration. Better understanding of these associations and their variation across plant life stages may help capture species shifts with ongoing climate change and be used to develop novel approaches to seed‐based restoration.

Read the free Plain Language Summary for this article on the Journal blog.
Impact of Oxygen Availability on the Organelle‐Specific Redox Potentials and Stress in Recombinant Protein Producing Komagataella phaffii
Authors: Kostopoulou Aliki , Rebnegger Corinna , Ferrero‐Bordera Borja , Mattanovich Matthias , Maaß Sandra , Becher Dörte , Gasser Brigitte , Mattanovich Diethard 
Published: February 2025

ABSTRACTThe yeast Komagataella phaffii (syn. Pichia pastoris) is a highly effective and well‐established host for the production of recombinant proteins. The redox balance of its secretory pathway, which is multi‐organelle dependent, is of high importance for producing secretory proteins. Redox imbalance and oxidative stress can significantly influence protein folding and secretion. Glutathione serves as the main redox buffer of the cell and cellular redox conditions can be assessed through the status of the glutathione redox couple (GSH‐GSSG). Previous research often focused on the redox potential of the endoplasmic reticulum (ER), where oxidative protein folding and disulphide bond formation occur. In this study, in vivo measurements of the glutathione redox potential were extended to different subcellular compartments by targeting genetically encoded redox sensitive fluorescent proteins (roGFPs) to the cytosol, ER, mitochondria and peroxisomes. Using these biosensors, the impact of oxygen availability on the redox potentials of the different organelles was investigated in non‐producing and producing K. phaffii strains in glucose‐limited chemostat cultures. It was found that the transition from normoxic to hypoxic conditions affected the redox potential of all investigated organelles, while the exposure to hyperoxic conditions did not impact them. Also, as reported previously, hypoxic conditions led to increased recombinant protein secretion. Finally, transcriptome and proteome analyses provided novel insights into the short‐term response of the cells from normoxic to hypoxic conditions.
Does it matter why we try? How goal‐focused extrinsic emotion regulation influences co‐worker's relational outcomes
Authors: Kunst Hannah , Nguyen Helena , Johnson Anya , MacCann Carolyn 
Published: February 2025

AbstractAt work and in everyday life, people regulate each other's emotions (i.e., extrinsic emotion regulation). To date, research on workplace extrinsic emotion regulation has focused primarily on the outcomes of regulation and less on why people regulate others' emotions (i.e., emotion regulation goals) and how they do it (i.e., the emotion regulation strategies used). In this paper, we investigate how regulation goals influence the regulation strategies people use to regulate their co‐workers' emotions, and how these relate to co‐worker relationship quality (conflict and team‐member exchange). Across three studies using experimental and field study designs (Study 1: N = 216; Study 2: N = 471; Study 3: N = 277 co‐workers regulated by N = 143 employees) we find that employees with pro‐hedonic goals are more likely to use the strategy of receptive listening (allowing co‐workers to talk about their problems), which is associated with lower relationship conflict. Employees with instrumental goals, specifically keeping up appearances at work, are more likely to use expressive suppression (asking co‐workers to suppress expressions of emotion), which is associated with higher relationship conflict and lower team‐member exchange. These results extend theoretical insights into extrinsic emotion regulation and have important practical implications for promoting high‐quality interactions between colleagues as well as interventions for building positive workplace cultures and emotion regulation norms within organizations.
Mechanistic Evaluation of Anti‐CD19 CAR‐T Cell Therapy Repurposed in Systemic Lupus Erythematosus Using a Quantitative Systems Pharmacology Model
Authors: Park Hyunseo , Mugundu Ganesh M. , Singh Aman P. 
Published: February 2025

ABSTRACTCAR‐T cell therapy, renowned for its success in oncology, is now venturing into the realm of B cell‐mediated autoimmune diseases. Recent observations have revealed significant pharmacological effects of CD19 CAR‐T cells in patients with systemic lupus erythematosus (SLE), suggesting promising applications in other autoimmune conditions. Consequently, as of December 2024, there are 116 different clinical trials evaluating CAR‐T cells against autoimmune conditions. While the field is starting to understand the overall pharmacological actions of CAR‐T cells in autoimmune diseases, the dose‐exposure‐response relationship remains inadequately characterized due to limited clinical data. To address these uncertainties, we have developed a Quantitative Systems Pharmacology (QSP) model using short‐term limited clinical data of anti‐CD19 CAR‐Ts in autoimmune disease patients (n = 5), followed by a model qualification step utilizing an external dataset (n = 13). The developed QSP model integrated and effectively characterized the (1) cellular kinetics of different immunophenotypic population of CAR‐T cells, (2) impact of lymphodepletion chemotherapy on host immune cells, (3) CAR‐mediated elimination of CD19+ B‐cells and (4) dynamic changes in disease surrogate biomarkers and its relationship with clinical score. The key pharmacological biomarkers which were incorporated within the QSP model included anti double stranded DNA (anti‐dsDNA) antibodies, proteinuria, C3 protein and IFN‐alpha. Later, a linear regression analysis‐based relationship was developed between continuous disease biomarkers and the categorical SLE disease activity index (SLE‐DAI) determined by the investigators offering a predictive framework for disease progression in SLE patients. This proposed QSP model holds potential to elucidate quantitative pharmacology and expedite clinical advancement of autologous and allogeneic cell therapies in autoimmune diseases.
Safety, tolerability, pharmacokinetics and pharmacodynamics of GZR4, a novel once‐weekly basal insulin, in healthy participants: A randomized trial
Authors: Tang Chengyong , Su Rui , Wan Lei , Zhu Mingxue , Pu Junliang , Hao Chunyue , Zhao Jing , He Anshun , Xie Tian , Li Yue , Chen Wei , Gan Zhong‐Ru 
Published: February 2025

AbstractAimsInsulin GZR4 (GZR4), a novel once‐weekly basal insulin, has demonstrated a favourable safety and low toxicity profile, as well as notable in vivo glycaemic control effects, in preclinical studies. The study aimed to evaluate the safety, tolerability, pharmacokinetics (PK) and pharmacodynamics (PD) of GZR4 in healthy Chinese participants.MethodsIn this randomized, single‐blind, dose‐escalation Phase 1a study, healthy male adults aged 18–45 years, with a BMI of 19–24 kg/m2 were enrolled in five cohorts. Participants in Cohorts 1–4 were randomized 4:1 to receive subcutaneous injections of GZR4 at doses of 1, 3, 6, and 12 nmol/kg or placebo. Participants in Cohort 5 received 0.4 U/kg (2.4 nmol/kg) of insulin degludec (IDeg). Euglycaemic glucose clamps were conducted 24–48 h (Day 2) and 144–168 h (Day 7) after GZR4 administration, and 0–24 h (Day 1) after IDeg administration. The primary endpoints were the safety and tolerability of GZR4.ResultsA total of 43 participants were enrolled, and 42 of them completed the study. No deaths, serious adverse events (SAEs), or discontinuations related to the investigational product were reported. The most common treatment‐emergent adverse events (TEAEs) were hypoglycaemia, which occurred exclusively in the 12 nmol/kg GZR4 group. All TEAEs were mild to moderate in severity. The PK parameters of GZR4 increased linearly with the dose from 1 to 12 nmol/kg, and the glucose‐lowering effect was sustained for approximately 1 week. The AUCGIR,24‐48h and AUCGIR,144‐168h for the 6 nmol/kg GZR4 dose (54.91 and 37.84 h × mg/kg/min) were comparable with that of IDeg (AUCGIR,0‐24h, 40.59 h × mg/kg/min), suggesting that GZR4's potency may be approximately 3.2‐times greater than IDeg weekly.ConclusionOnce‐weekly GZR4 demonstrated good safety and tolerability in healthy participants. It exhibited a dose‐dependent and sustained glucose‐lowering effect over a full week and demonstrated stronger daily glucose‐lowering efficacy than once‐daily IDeg under similar molar concentrations. These results support further investigation of once‐weekly GZR4 for glycaemic control in patients with diabetes.
Cognitive Remediation for Adolescents With Mental Health Disorders: A Systematic Review and Meta‐Analysis
Authors: East‐Richard Caroline , Cayouette Audrey , Allott Kelly , Anderson Élizabeth , Haesebaert Frédéric , Cella Matteo , Cellard Caroline 
Published: February 2025

ABSTRACTIntroductionThe effects of cognitive remediation therapy (CRT) in adults with mental health disorders have been widely documented, but its effects in adolescents with mental health disorders remain poorly understood. This review aims to (1) determine the effects of CRT on cognition, symptoms and functioning for adolescents with mental health disorders and (2) evaluate the methodological quality of studies on CRT.MethodsA systematic review and meta‐analysis were conducted of randomised controlled trials of CRT involving adolescents with mental health disorders. Searches were conducted in databases for studies pertaining to CRT effects on cognition, social functioning and clinical symptoms. Methodological quality was assessed using the Clinical Trials Assessment Measure.ResultsFourteen studies (N = 14) were included, with 11 independent samples (k = 11, 592 participants). Participants had various mental health disorders. CRT showed a small significant effect on cognition (g = 0.14, p = 0.02), particularly on processing speed, working memory and episodic memory. No significant effects were found for clinical symptoms (g = 0.04, p = 0.58) and social functioning (g = 0.06, p = 0.39). Methodological quality of included studies was variable, ranging from poor to good quality.ConclusionIncluded studies showed a small significant effect of CRT on cognition, and non‐significant effects on clinical symptoms and social functioning in adolescents with mental health disorders. The lack of effects may be partly explained by limitations in the methodology of included studies. A critical analysis of current studies is presented and recommendations of core techniques to consider for future CRT studies are discussed.
The impact of nonmarket strategies in the CEE region: Evidence from Romanian and polish firms
Authors: Parnell John A. , Văduva Sebastian , Fotea Silvia 
Published: February 2025

AbstractWe surveyed 249 Polish and 159 Romanian firms about their nonmarket strategies (NMS). The results revealed similar links among relative firm size, market strategies, NMS, and firm performance. Firm size did not influence market orientation, but it influenced political and social NMS. Firm performance was influenced primarily by global growth and differentiation, not cost leadership. Social NMS, but not political NMS, was a significant performance driver in both countries. Relative firm size was significantly associated with firm performance in Romania but not Poland. Our findings suggest that firms in Central and Eastern Europe (CEE) can integrate market and NMS to drive performance, but NMS creates more value in the social realm than in the political sphere.