bluuebunny/crossref_metadata_2025_split huggingface dataset:
Digital Amputation in Systemic Sclerosis: Prevalence and Clinical Associations. A Retrospective Longitudinal Study
Authors: CARAMASCHI PAOLA , BIASI DOMENICO , CAIMMI CRISTIAN , BARAUSSE GIOVANNI , SABBAGH DANIA , TINAZZI ILARIA , LA VERDE VALENTINA , TONETTA SARA , ADAMI SILVANO 
Published: June 2012

Objective.To evaluate the prevalence of digital necrosis requiring surgical amputation in a single-center group of patients with systemic sclerosis (SSc) and to compare the characteristics of patients with and those without this severe complication.Methods.We reviewed the medical records of 188 patients with SSc [162 women, 26 men, mean age 59.2 yrs, mean disease duration 8.0 yrs, mean time from onset of Raynaud’s phenomenon (RP) 11.7 yrs, median followup duration 92 mo] enrolled in the Rheumatology Unit since 2004. Demographic and clinical features were collected, as well as the presence of the typical risk factors for atherosclerosis.Results.Nine patients (4.8%) underwent partial or total surgical digital amputation because of necrotic process; all these patients except 1 had a long history of multiple and persisting digital ulcers. All 9 patients had concomitant large-vessel involvement. Comparison of cases with and without digital amputation showed that this complication was associated with older age, long history of RP, long disease duration, presence of anticentromere antibody, and coexistence of peripheral artery disease and hypercholesterolemia.Discussion.We noted that 4.8% of patients with SSc underwent digital amputation. Our retrospective analysis suggests that peripheral artery disease is strongly associated with digital amputation. The preventive strategy for digital ulcers and amputation associated with SSc should include an extensive diagnostic and preventive investigation for peripheral atherosclerosis.
Y a-t-il une machine derrière la machine ?
Authors: Zimra Georges 
Published: June 2012

L’homme et la machine sont désormais dans un rapport de consubstantialité. Impossible de penser l’homme sans la technique, impossible de penser le monde sans les machines. Le problème est de savoir comment cette dépendance s’est organisée à travers les discours philosophique, médical, économique. Comment la langue s’en trouve profondément transformée et comment cette transformation nous affecte en retour ? La question donc n’est pas tant de nous défier des machines mais de nous demander à quoi servent-elles ? Qui servent-elles ? À quelle idéologie obéissent-elles ? Faut-il machiner les hommes ou humaniser les machines ? C’est toute une conception que nous nous faisons du monde qui est ici posée et qui organise le lien social en politique.
Lacan et les états-limites
Authors: Lebrun Jean-Pierre 
Published: June 2012

Lacan ne cautionnait nullement ce concept d’« état-limite ». Il s’y est opposé par exigence de ne pas céder sur le fait d’avoir à répondre de la structure, névrotique, psychotique ou perverse. Pourtant, la phénoménologie des états-limites est de plus en plus fréquente. Y aurait-il là une quatrième structure ? Pour en rendre compte, j’ai parlé de perversion ordinaire , mais aussi de sujet des limbes , ou de mèreversion , et plus tard encore d’une économie de l’arrière pays. Ne serait-ce pas en ce cas toujours une névrose mais qui, effectivement, n’est plus patrocentrée ? De ce fait, la névrose orientée seulement selon le versant maternel – qui, rappelons-le, ne fait pas centre – est favorisée et donc est valorisée non pas une nouvelle économie psychique au sens d’un changement radical mais une névrose qui se présente très différemment. S’en suit une série de conséquences qu’il s’agit d’éclairer.
La dette : illusion comptable et aveuglement suicidaire
Authors: Moulier-Boutang Yann 
Published: June 2012

Résumé Après avoir distingué entre différents types de dette, cet article propose une réflexion de fond sur l’obsolescence de la façon dont nos calculs économiques comptabilisent la création de richesse. La crise de la dette est d’abord une crise de la mesure. L’analogie de la pollinisation permet de faire comprendre ce dont il s’agit : nous ne comptons que le miel produit par nos activités sans inclure la pollinisation, ni prendre soin de la survie des abeilles. La dette est un artifice comptable, qui résulte de cette double cécité, dont certains abusent pour exploiter les autres. Elle risque de nous faire tous sombrer dans son aveuglement.
La dette est-elle bonne ou mauvaise ?
Authors: Guérin Isabelle 
Published: June 2012

Résumé Le microcrédit, en Inde comme ailleurs, a été présenté ces dernières années comme un outil d’éradication de la pauvreté, permettant d’abolir des formes d’endettement informelles asservissantes, de soutenir la diffusion du capitalisme populaire et de promouvoir l’émancipation féminine. Plusieurs années de recherche en Inde rurale du Sud (Tamil Nadu) montrent que le microcrédit a surtout pour effet de renforcer une « démocratie de patronage ». La dette, sous toutes ses formes, reste un puissant moteur de paupérisation des travailleurs pauvres mais aussi de construction des identités individuelles et collectives et de différentiation sociale.
Autocrine IFN-γ Promotes Naive CD8 T Cell Differentiation and Synergizes with IFN-α To Stimulate Strong Function
Authors: Curtsinger Julie M. , Agarwal Pujya , Lins Debra C. , Mescher Matthew F. 
Published: June 2012

AbstractAutocrine IFN-γ signaling is important for CD4 differentiation to Th1 effector cells, but it has been unclear whether it contributes to CD8 T cell differentiation. We show in this paper that naive murine CD8 T cells rapidly and transiently produce low levels of IFN-γ upon stimulation with Ag and B7-1, with production peaking at ∼8 h and declining by 24 h. The autocrine IFN-γ signals for upregulation of expression of T-bet and granzyme B and induces weak cytolytic activity and effector IFN-γ production. IFN-α acts synergistically with IFN-γ to support development of strong effector functions, whereas IL-12 induces high T-bet expression and strong function in the absence of IFN-γ signaling. Thus, IFN-γ is not only an important CD8 T cell effector cytokine, it is an autocrine/paracrine factor whose contributions to differentiation vary depending on whether the response is supported by IL-12 or type I IFN.
TGF-β Mediates Proinflammatory Seminal Fluid Signaling in Human Cervical Epithelial Cells
Authors: Sharkey David J. , Macpherson Anne M. , Tremellen Kelton P. , Mottershead David G. , Gilchrist Robert B. , Robertson Sarah A. 
Published: June 2012

AbstractThe cervix is central to the female genital tract immune response to pathogens and foreign male Ags introduced at coitus. Seminal fluid profoundly influences cervical immune function, inducing proinflammatory cytokine synthesis and leukocyte recruitment. In this study, human Ect1 cervical epithelial cells and primary cervical cells were used to investigate agents in human seminal plasma that induce a proinflammatory response. TGF-β1, TGF-β2, and TGF-β3 are abundant in seminal plasma, and Affymetrix microarray revealed that TGF-β3 elicits changes in Ect1 cell expression of several proinflammatory cytokine and chemokine genes, replicating principal aspects of the Ect1 response to seminal plasma. The differentially expressed genes included several induced in the physiological response of the cervix to seminal fluid in vivo. Notably, all three TGF-β isoforms showed comparable ability to induce Ect1 cell expression of mRNA and protein for GM-CSF and IL-6, and TGF-β induced a similar IL-6 and GM-CSF response in primary cervical epithelial cells. TGF-β neutralizing Abs, receptor antagonists, and signaling inhibitors ablated seminal plasma induction of GM-CSF and IL-6, but did not alter IL-8, CCL2 (MCP-1), CCL20 (MIP-3α), or IL-1α production. Several other cytokines present in seminal plasma did not elicit Ect1 cell responses. These data identify all three TGF-β isoforms as key agents in seminal plasma that signal induction of proinflammatory cytokine synthesis in cervical cells. Our findings suggest that TGF-β in the male partner’s seminal fluid may influence cervical immune function after coitus in women, and potentially be a determinant of fertility, as well as defense from infection.
Platelets Present Antigen in the Context of MHC Class I
Authors: Chapman Lesley M. , Aggrey Angela A. , Field David J. , Srivastava Kalyan , Ture Sara , Yui Katsuyuki , Topham David J. , Baldwin William M. , Morrell Craig N. 
Published: June 2012

Abstract
Platelets are most recognized for their vital role as the cellular mediator of thrombosis, but platelets also have important immune functions. Platelets initiate and sustain vascular inflammation in many disease conditions, including arthritis, atherosclerosis, transplant rejection, and severe malaria. We now demonstrate that platelets express T cell costimulatory molecules, process and present Ag in MHC class I, and directly activate naive T cells in a platelet MHC class I-dependent manner. Using an experimental cerebral malaria mouse model, we also demonstrate that platelets present pathogen-derived Ag to promote T cell responses in vivo, and that platelets can be used in a cell-based vaccine model to induce protective immune responses. Our study demonstrates a novel Ag presentation role for platelets.
Differential Idiotype Utilization for the In Vivo Type 14 Capsular Polysaccharide-Specific Ig Responses to Intact Streptococcus pneumoniae versus a Pneumococcal Conjugate Vaccine
Authors: Colino Jesus , Duke Leah , Arjunaraja Swadhinya , Chen Quanyi , Liu Leyu , Lucas Alexander H. , Snapper Clifford M. 
Published: June 2012

Abstract
Murine IgG responses specific for the capsular polysaccharide (pneumococcal capsular polysaccharide serotype 14; PPS14) of Streptococcus pneumoniae type 14 (Pn14), induced in response to intact Pn14 or a PPS14–protein conjugate, are both dependent on CD4+ T cell help but appear to use marginal zone versus follicular B cells, respectively. In this study, we identify an idiotype (44.1-Id) that dominates the PPS14-specific IgG, but not IgM, responses to intact Pn14, isolated PPS14, and Group B Streptococcus (strain COH1-11) expressing capsular polysaccharide structurally identical to PPS14. The 44.1-Id, however, is not expressed in the repertoire of natural PPS14-specific Abs. In distinct contrast, PPS14-specific IgG responses to a soluble PPS14–protein conjugate exhibit minimal usage of the 44.1-Id, although significant 44.1-Id expression is elicited in response to conjugate attached to particles. The 44.1-Id elicited in response to intact Pn14 was expressed in similar proportions among all four IgG subclasses during both the primary and secondary responses. The 44.1-Id usage was linked to the Igha, but not Ighb, allotype and was associated with induction of relatively high total PPS14-specific IgG responses. In contrast to PPS14–protein conjugate, avidity maturation of the 44.1-Id–dominant PPS14-specific IgG responses was limited, even during the highly boosted T cell-dependent PPS14-specific secondary responses to COH1-11. These results indicate that different antigenic forms of the same capsular polysaccharide can recruit distinct B cell clones expressing characteristic idiotypes under genetic control and suggest that the 44.1-Id is derived from marginal zone B cells.
Cutting Edge: Mast Cells Critically Augment Myeloid-Derived Suppressor Cell Activity
Authors: Saleem Sheinei J. , Martin Rebecca K. , Morales Johanna K. , Sturgill Jamie L. , Gibb David R. , Graham Laura , Bear Harry D. , Manjili Masoud H. , Ryan John J. , Conrad Daniel H. 
Published: June 2012

Abstract
Myeloid-derived suppressor cells (MDSCs) are primarily recognized for their immunosuppressive properties in malignant disease. However, their interaction with other innate immune cells and their regulation of immune responses, such as in parasitic infection, necessitate further characterization. We used our previously published mouse model of MDSC accumulation to examine the immunoregulatory role of MDSCs in B16 melanoma metastasis and Nippostrongylus brasiliensis infection. In this study, we demonstrate that the activity of MDSCs is dependent on the immune stimuli and subset induced. Monocytic MDSCs predictably suppressed antitumor immune responses but granulocytic MDSCs surprisingly enhanced the clearance of N. brasiliensis infection. Intriguingly, both results were dependent on MDSC interaction with mast cells (MCs), as demonstrated by adoptive-transfer studies in MC-deficient (KitWsh/Wsh) mice. These findings were further supported by ex vivo cocultures of MCs and MDSCs, indicating a synergistic increase in cytokine production. Thus, MCs can enhance both immunosuppressive and immunosupportive functions of MDSCs.
Analysis of T Cell Responses to the Major Allergens from German Cockroach: Epitope Specificity and Relationship to IgE Production
Authors: Oseroff Carla , Sidney John , Tripple Victoria , Grey Howard , Wood Robert , Broide David H. , Greenbaum Jason , Kolla Ravi , Peters Bjoern , Pomés Anna , Sette Alessandro 
Published: June 2012

Abstract
Bla g allergens are major targets of IgE responses associated with cockroach allergies. However, little is known about corresponding T cell responses, despite their potential involvement in immunopathology and the clinical efficacy of specific immunotherapy. Bioinformatic predictions of the capacity of Bla g 1, 2, 4, 5, 6, and 7 peptides to bind HLA-DR, -DP, and -DQ molecules, and PBMC responses from 30 allergic donors, identified 25 T cell epitopes. Five immunodominant epitopes accounted for more than half of the response. Bla g 5, the most dominant allergen, accounted for 65% of the response, and Bla g 6 accounted for 20%. Bla g 5 induced both IL-5 and IFN-γ responses, whereas Bla g 6 induced mostly IL-5, and, conversely, Bla g 2 induced only IFN-γ. Thus, responses to allergens within a source are independently regulated, suggesting a critical role for the allergen itself, and not extraneous stimulation from other allergens or copresented immunomodulators. In comparing Ab with T cell responses for several donor/allergen combinations, we detected IgE titers in the absence of detectable T cell responses, suggesting that unlinked T cell–B cell help might support development of IgE responses. Finally, specific immunotherapy resulted in IL-5 downmodulation, which was not associated with development of IFN-γ or IL-10 responses to any of the Bla g-derived peptides. In summary, the characteristics of T cell responses to Bla g allergens appear uncorrelated with IgE responses. Monitoring these responses may therefore yield important information relevant to understanding cockroach allergies and their treatment.
Exogenous Administration of 15d-PGJ2–Loaded Nanocapsules Inhibits Bone Resorption in a Mouse Periodontitis Model
Authors: Napimoga Marcelo H. , da Silva Carlos A. T. , Carregaro Vanessa , Farnesi-de-Assunção Thais S. , Duarte Poliana M. , de Melo Nathalie F. S. , Fraceto Leonardo F. 
Published: June 2012

Abstract
The 15-deoxy-Δ12,14-PG J2 (15d-PGJ2) has demonstrated excellent anti-inflammatory results in different experimental models. It can be used with a polymeric nanostructure system for modified drug release, which can change the therapeutic properties of the active principle, leading to increased stability and slower/prolonged release. The aim of the current study was to test a nanotechnological formulation as a carrier for 15d-PGJ2, and to investigate the immunomodulatory effects of this formulation in a mouse periodontitis model. Poly (D,L-lactide-coglycolide) nanocapsules (NC) were used to encapsulate 15d-PGJ2. BALB/c mice were infected on days 0, 2, and 4 with Aggregatibacter actinomycetemcomitans and divided into groups (n = 5) that were treated daily during 15 d with 1, 3, or 10 μg/kg 15d-PGJ2-NC. The animals were sacrificed, the submandibular lymph nodes were removed for FACS analysis, and the jaws were analyzed for bone resorption by morphometry. Immunoinflammatory markers in the gingival tissue were analyzed by reverse transcriptase-quantitative PCR, Western blotting, or ELISA. Infected animals treated with the 15d-PGJ2-NC presented lower bone resorption than infected animals without treatment (p &lt; 0.05). Furthermore, infected animals treated with 10 μg/kg 15d-PGJ2-NC had a reduction of CD4+CD25+FOXP3+ cells and CD4/CD8 ratio in the submandibular lymph node (p &lt; 0.05). Moreover, CD55 was upregulated, whereas RANKL was downregulated in the gingival tissue of the 10 μg/kg treated group (p &lt; 0.05). Several proinflammatory cytokines were decreased in the group treated with 10 μg/kg 15d-PGJ2-NC, and high amounts of 15d-PGJ2 were observed in the gingiva. In conclusion, the 15d-PGJ2-NC formulation presented immunomodulatory effects, decreasing bone resorption and inflammatory responses in a periodontitis mouse model.
CD2AP/SHIP1 Complex Positively Regulates Plasmacytoid Dendritic Cell Receptor Signaling by Inhibiting the E3 Ubiquitin Ligase Cbl
Authors: Bao Musheng , Hanabuchi Shino , Facchinetti Valeria , Du Qiumei , Bover Laura , Plumas Joel , Chaperot Laurence , Cao Wei , Qin Jun , Sun Shao-Cong , Liu Yong-Jun 
Published: June 2012

Abstract
The human plasmacytoid dendritic cell (pDC) receptor BDCA2 forms a complex with the adaptor FcεR1γ to activate an ITAM-signaling cascade. BDCA2 receptor signaling negatively regulates the TLR7/9-mediated type 1 IFN responses in pDCs, which may play a key role in controlling self-DNA/RNA–induced autoimmunity. We report in this article that CD2-associated adaptor protein (CD2AP), which is highly expressed in human pDCs, positively regulates BDCA2/FcεR1γ receptor signaling. By immunoprecipitation and mass spectrometry analyses, we found that CD2AP bound to SHIP1. Knockdown of CD2AP or SHIP1 reduced the BDCA2/FcεR1γ-mediated ITAM signaling and blocked its inhibition of TLR9-mediated type 1 IFN production. Knockdown of CD2AP or SHIP1 also enhanced the ubiquitination and degradation of Syk and FcεR1γ that was mediated by the E3 ubiquitin ligase Cbl. This led us to discover that, upon BDCA2 cross-linking, the CD2AP/SHIP1 complex associated with Cbl and inhibited its E3 ubiquitin ligase activity. In human primary pDCs, cross-linking of the BDCA2/FcεR1γ complex induced the recruitment of the CD2AP/SHIP1/Cbl complex to the plasma membrane of pDCs, where it colocalized with the BDCA2/FcεR1γ complex. Therefore, CD2AP positively regulates BDCA2/FcεR1γ signaling by forming a complex with SHIP1 to inhibit the E3 ubiquitin ligase Cbl.
A Clinical Study on Dental Air Force Home Dental Cleaning System on Adult Chronic Periodontitis Patients and its Assessment to C-Reactive Protein Levels
Authors: Vadvadgi Vinay , Anarthe Raju , Mani Shubhangi 
Published: June 2012

ABSTRACT

Aim
The study was outlined to determine and assess the C-reactive protein (CRP) level in chronic periodontitis patients and to assess the CRP values after using Dental Air Force home dental cleaning system.

Materials and methods
A total of 100 adult chronic periodontitis subjects were recruited voluntarily for this study. Clinical assessment of plaque index, gingival index, probing depth, clinical attachment level and C-reactive protein (CRP) levels were made prior to phase-1 therapy and at 7th and 15th day posttherapy. Effects of treatment were assessed by paired tests and analysis of variance by treatment group with baseline covariates. Comparative assessments were done among all the patients that were divided into four groups.

Results
The results of this study showed that there was 35% decrease in CRP level in periodontitis patients that used Dental Air Force home dental cleaning system without undergoing phase 1 (complete scaling and root planing) therapy. There was 100% decrease in CRP in group D (phase 1 therapy followed by use of Dental Air Force home dental cleaning system) as compare to group C (phase 1 therapy followed by use of toothbrush) where there were 89.61% decrease in CRP level from baseline to 15th day of recordings.

Conclusion
There was strong correlation between periodontal diseases and CRP level and as there is progression and remission of periodontal disease; CRP values follow the same. Dental Air Force home dental cleaning system with the access to interdentally area helps in preventing the accumulation of dental plaque biofilm, thus able to maintain the CRP at lower levels as compare to traditional toothbrushing.

How to cite this article
Mani A, Vadvadgi V, Anarthe R, Saini R, Mani S. A Clinical Study on Dental Air Force Home Dental Cleaning System on Adult Chronic Periodontitis Patients and its Assessment to C-Reactive Protein Levels. Int J Exper Dent Sci 2012;1(1):14-18.
Case of Compound Composite Odontome: Diagnostic Criteria for Odontomas
Authors: Tejasvi Avinash , Babu Balaji , Avinash CK Anulekha , Venkateswarlu M , Geetha P , Kinikar Ketaki , Afroze Malik 
Published: June 2012

ABSTRACT
Odontomas behave more like developmental abnormalities (hamartomas) than true neoplasms. Odontomas are developmental anomalies resulting from the growth of completely differentiated epithelial and mesenchymal cells that give rise to ameloblast and odontoblast. Odontomas are classified as complex odontoma and compound odontomas. The purpose of the article is to enumerate the diagnostic criteria for odontomas.

How to cite this article
Tejasvi A, Babu B, Avinash CKA, Venkateswarlu M, Geetha P, Kinikar K, Afroze M. Case of Compound Composite Odontome: Diagnostic Criteria for Odontomas. Int J Exper Dent Sci 2012;1(1):19-22.
Inverted and Impacted Maxillary Third Molar: Removal by Lateral Transposition Method
Authors: Chhabra Shruti , Chhabra Naveen , Dhillon Guneet 
Published: June 2012

ABSTRACT

Background
Third molars are one of the most commonly impacted teeth in the oral cavity. But in very rare cases, the impacted molars can be inverted as well. In this case, the patient presented with an inverted and impacted left maxillary third molar. The aim of the operating surgeon was to execute the procedure in the least hazardous manner, to avoid any surgical complications.

Methods
The surgical extraction of the tooth by lateral transposition method was carried out rather than the classical method owing to the inverted position of the impacted tooth. The surgery was carried out under local anesthesia. An incision was made at the crest of the ridge with an anterior releasing incision. Bone overlying the impacted molar was removed following which the tooth was luxated and laterally transposed. The socket was thoroughly irrigated and closure was done by simple interrupted suture, using 3-0 mersilk.

Results
The impacted and inverted maxillary third molar was successfully removed by lateral transposition method without any complications.

Conclusion
The impacted and inverted maxillary third molars are not commonly encountered in dental practice. Subsequently, their removal can be a challenging job on the part of an oral surgeon. The surgeon should preoperatively weigh carefully the associated risk factors and explain them thoroughly to the patient.

How to cite this article
Chhabra S, Chhabra N, Dhillon G. Inverted and Impacted Maxillary Third Molar: Removal by Lateral Transposition Method. Int J Exper Dent Sci 2012;1(1):26-29.
Nonsurgical Endodontic Retreatment: A Case of Dental Quackery
Authors: Tewari Rajendra Kumar , Mishra Surendra Kumar , Kharade Pankaj 
Published: June 2012

ABSTRACTDental quackery is a common practice in India. The poor people who cannot afford for specialty dental treatment prefer to go to unregistered cheap dental practitioners. A case of self-styled fixation of traumatic maxillary anterior teeth reported in Department of Conservative Dentistry, Dental College, AMU, Aligarh and was treated successfully.How to cite this articleTewari RK, Mishra SK, Sharma S, Kharade P. Nonsurgical Endodontic Retreatment: A Case of Dental Quackery. Int J Exper Dent Sci, 2012;1(1):34-36.