bluuebunny/crossref_metadata_2025_split huggingface dataset:
Psychiatric and Medical Comorbidity and Quality of Life Outcomes in Childhood-Onset Epilepsy
Authors: Baca Christine B. , Vickrey Barbara G. , Caplan Rochelle , Vassar Stefanie D. , Berg Anne T. 
Published: November 2011

OBJECTIVE:We compared associations of epilepsy remission status and severity as well as psychiatric and other comorbidities with child and parent-proxy reports of health-related quality of life (HRQoL) in adolescents previously diagnosed with epilepsy.METHODS:In a prospective, community-based study of newly diagnosed childhood epilepsy, HRQoL of 277 children was assessed 8 to 9 years after diagnosis by using child and parent-proxy versions of the Child Health Questionnaire (CHQ). Multiple linear regression models adjusted for age and gender were used to compare associations of epilepsy remission and “complicated” epilepsy (secondary to an underlying neurologic insult or epileptic encephalopathy) status and psychiatric and other comorbidities with HRQoL.RESULTS:Mean age of epilepsy onset was 4.4 years (SD: 2.6). At the 9-year reassessment, children were, on average, 13.0 years old (SD: 2.6); 64% were seizure-free for 5 years, 31% were taking antiepileptic drugs, and 19% had a complicated epilepsy. Prevalence of comorbidities at follow-up were 26% psychiatric diagnosis; 39% neurodevelopmental spectrum disorder (NDSD); 24% chronic medical illness; and 15% migraine. In multivariable analysis, having a psychiatric disorder was broadly associated with child (6 of 11 scales) and parent-proxy (7 of 12 scales) HRQoL (P ≤ .0125). Five-year remission and complicated epilepsy status had few or no associations with HRQoL. Although parent-proxy HRQoL was strongly associated with NDSD (6 of 11 scales), child-reported HRQoL was not (2 of 11 scales).CONCLUSIONS:Psychiatric comorbidities are strongly associated with long-term HRQoL in childhood-onset epilepsy, which suggests that comprehensive epilepsy care must include screening and treatment for these conditions, even if seizures remit.
Thoughts on Thinking: Engaging Novice Music Students in Metacognition
Authors: Bathgate Meghan , Sims‐Knight Judith , Schunn Christian 
Published: November 2011

SummaryAchieving expertise in any area requires extensive practice and engagement with the subject one desires to master. As not all practice yields good progress, methods must be found that lead learners to practice effectively. Many experts employ highly tailored practice involving metacognitive processes, but novices rarely engage in frequent and explicit metacognitive strategies during practice. As a result, novice progress may be impeded through repetition of systematic errors and ineffective techniques. Our study provides evidence of the effectiveness of teaching metacognition to novice music students through weekly lessons. Thirty‐five adolescent students of six instructors were randomly assigned to metacognitive focus or existing practice teaching conditions. Students receiving metacognitive teaching achieved higher performance ratings when compared with students receiving control instruction, even though practice time did not vary between groups. These results suggest that having students explicitly verbalize and reflect on their learning process produces more efficient practice and greater end performance. Copyright © 2011 John Wiley & Sons, Ltd.
Heterogeneous Green Catalyst for Oxidation of Cyclohexene and Cyclooctene with Hydrogen Peroxide in the Presence of Host (Nanocavity of Y‐zeolite)/Guest (N4‐Cu(II) Schiff Base Complex) Nanocomposite Material
Authors: Lashanizadegan Maryama , Rayati Saeed , Dejparvar Derakhshan Zeinab 
Published: November 2011

AbstractCopper(II) complex of a Schiff base ligand derived from pyrrolcarbaldehyde and o‐phenylenediamine (H2L) has been synthesized and encapsulated in Y‐zeolite matrix. The hybrid material has been characterized by elemental analysis, IR and UV‐Vis spectroscopic studies as well as X‐ray diffraction (XRD) pattern. The encapsulated copper(II) catalyst is an active catalyst for the oxidation of cyclooctene and cyclohexene using H2O2 as oxidant. Under the optimized reaction conditions 81% conversion of cyclohexene with 65% selectivity for 2‐cyclohexenone formation and 87% conversion of cyclooctene with 46% selectivity for epoxide formation were obtained.
Validation of the Essential ClpP Protease in Mycobacterium tuberculosis as a Novel Drug Target
Authors: Ollinger Juliane , O'Malley Theresa , Kesicki Edward A. , Odingo Joshua , Parish Tanya 
Published: November 2011

ABSTRACT

Mycobacterium tuberculosis
is a pathogen of major global importance. Validated drug targets are required in order to develop novel therapeutics for drug-resistant strains and to shorten therapy. The Clp protease complexes provide a means for quality control of cellular proteins; the proteolytic activity of ClpP in concert with the ATPase activity of the ClpX/ClpC subunits results in degradation of misfolded or damaged proteins. Thus, the Clp system plays a major role in basic metabolism, as well as in stress responses and pathogenic mechanisms.
M. tuberculosis
has two ClpP proteolytic subunits. Here we demonstrate that ClpP1 is essential for viability in this organism in culture, since the gene could only be deleted from the chromosome when a second functional copy was provided. Overexpression of
clpP1
had no effect on growth in aerobic culture or viability under anaerobic conditions or during nutrient starvation. In contrast,
clpP2
overexpression was toxic, suggesting different roles for the two homologs. We synthesized known activators of ClpP protease activity; these acyldepsipeptides (ADEPs) were active against
M. tuberculosis
. ADEP activity was enhanced by the addition of efflux pump inhibitors, demonstrating that ADEPs gain access to the cell but that export occurs. Taken together, the genetic and chemical validation of ClpP as a drug target leads to new avenues for drug discovery.
Thermal Behavior of Sr(II) and Ba(II)‐Diclofenac Complexes in Solid State: Study of the Dehydration and Thermal Decomposition
Authors: Kobelnik Marcelo , Cassimiro Douglas Lopes , Santos Diógenesdos Dos , Ribeiro Clóvis Augusto , Crespi Marisa Spirandeli 
Published: November 2011

AbstractSolid state compounds of general formula Sr(Diclof)2·5.7H2O and Ba(Diclof)2·4.8H2O were obtained. Thermogravimetry (TG), differential scanning calorimetry (DSC), X‐ray diffraction powder patterns and microscopy analysis were used to characterize these compounds. Details concerning the dehydration and thermal decomposition as well as data of kinetic parameters have been described here. The kinetic behaviors of these stages were evaluated from several heating rates with samples masses of 2 and 5 mg in open crucibles under a nitrogen atmosphere. The results of the present study improve the knowledge on these compounds including their dehydration and thermal stability. The obtained data depend on the mass of the sample which results in two kinetic behavior patterns.
Enhanced Visible‐Light‐Induced Photoelectrocatalytic Degradation of Methyl Orange by CdS Sensitized TiO2 Nanotube Arrays Electrode
Authors: Jiang Dawei , Zhou Tianshu , Sun Qi , Yu Yanyan , Shi Guoyue , Jin Litong 
Published: November 2011

AbstractIn this work, CdS sensitized TiO2 nanotube arrays (CdS/TiO2NTs) electrode was synthesized with the CdS deposition on the highly ordered titanium dioxide nanotube arrays (TiO2NTs) by sequential chemical bath deposition method (S‐CBD). The as‐prepared CdS/TiO2NTs was characterized by field‐emission scanning electron microscopy (FE‐SEM) and X‐ray diffraction (XRD). The results indicated that the CdS nanoparticles were effectively deposited on the surface of TiO2NTs. The amperometric I‐t curve on the CdS/TiO2NTs electrode was also presented. It was found that the photocurrent density was enhanced significantly from 0.5 to 1.85 mA/cm2 upon illumination with applied potential of 0.5 V at the central wavelength of 253.7 nm. The photoelectrocatalytic (PEC) activity of the CdS/TiO2NTs electrode was investigated by degradation of methyl orange (MO) in aqueous solution. Compared with TiO2NTs electrode, the degradation efficiencies of CdS/TiO2NTs electrode increased from 78% to 99.2% under UV light in 2 h, and from 14% to 99.2% under visible light in 3 h, which was caused by effective separation of the electrons and holes due to the effect of CdS, hence inhibiting the recombination of electron/hole pairs of TiO2NTs.
FARMERS' WILLINGNESS TO PAY FOR AGRICULTURAL EXTENSION SERVICE: EVIDENCE FROM NIGERIA
Authors: Ozor Nicholas , Garforth Chris J. , Madukwe Michael C. 
Published: November 2011

AbstractThe study was undertaken to investigate how willing would farmers be to pay for agricultural extension service in Nigeria. A multistage random sampling technique was used to select 268 respondents. Results showed that most farmers (95.1 per cent) were willing to pay for improved extension service as long as the service remained relevant to their needs. Farmers were willing to pay N1000 annually as their own share of the service cost. The most important factors that influenced farmers' willingness to pay were states of origin, items originally paid for, major occupation, minor occupation, number of years in school and sale of farm produce. Copyright © 2011 John Wiley & Sons, Ltd.
Patterns of subjective quality of life among older adults in rural Vietnam and Indonesia
Authors: Van Minh Hoang , Ng Nawi , Byass Peter , Wall Stig 
Published: November 2011

Aim:  This paper aims to assess the subjective quality of life (SQOL) and its correlates among older adults in rural communities of Vietnam and Indonesia.Methods:  The paper uses the data from the INDEPTH/WHO Study on global aging and adult health (SAGE). The study was carried out in the FilaBavi Health and Demographic Surveillance System (HDSS) site in Vietnam and in Purworejo HDSS in Indonesia. All people aged 50 years and over who lived in these two HDSS areas were surveyed. Face‐to‐face household interviews were carried out by trained surveyors using the standardized summary version of the INDEPTH/WHO SAGE questionnaire. The SQOL was assessed by asking the respondents “How would you rate your overall quality of life?” The response set was a five‐point scale where 1 = Very good, 2 = Good, 3 = Moderate, 4 = Bad, 5 = Very bad.Results:  In both countries, the SQOL was reported to be higher among (i) men; (ii) people with higher education; (iii) people who were in a marital partnership; (iv) people who lived with other family members; and (v) those with higher economic status, compared with that in those of other category(ies) of the same characteristic. In Vietnam, people who belonged to the second to fifth economic quintiles and had more than 6 years of education were sevenfold more likely to report very good/good quality of life compared with those who belonged to the first economic quintile (poorest) and had no formal education. The corresponding figure was 2.7 for Indonesia.Conclusions:  The patterns of sociodemographic determinants of SQOL show that inequality in quality of life exists among older adults in the two study settings. Geriatr Gerontol Int 2012; 12: 397–404.
Effective professional development for e‐learning: What do the managers think?
Authors: Wilson Amy 
Published: November 2011

AbstractIntroducing new methods of teaching and learning requires an institutional approach to professional development in order to cater for the different levels and requirements of staff. The increase in e‐learning use has prompted many institutions to adopt a whole organisation approach to professional development for lecturers.This paper proposes to answer three related questions. How do institutions of vocational education within New Zealand structure their institutional provision of e‐learning professional development? What training or other development opportunities are provided by institutions? What do e‐learning managers feel are the types of e‐learning professional development that work best in terms of lecturer development and support?A literature review was completed and interviews were held with e‐learning managers from 13 institutions. The data collected from the interviews were then analysed using a grounded analysis approach.The analysis process yielded concepts that were related to different types of professional development training, information and support. The analysis provided a structure of professional development. Furthermore, the efficiency of the types of e‐learning professional development was analysed based on e‐learning managers' perception and evaluation models. Professional development with opportunities for skill acquisition and collaboration was deemed the most effective.Practitioner NotesWhat is already known about this topic
Academic staff need new skills to teach e‐learning.
There are different levels of professional development, which vary in duration and scope.
Professional development needs to be relevant for academic staff to benefit.
What this paper adds
This paper discusses the types of professional development made available at tertiary institutions for staff new to e‐learning.
This paper explains what e‐learning managers feel is the most effective professional development format.
This paper analyses why the e‐learning managers feel this format is the most effective.
Implications for practice and/or policy
Managers will be better informed why particular types of professional development for e‐learning work well.
Academic staff will be better informed about what professional development might best suit them.
Academic staff will be better informed about what managers feel about effective professional development and be able to have a greater role in the evaluation feedback cycle.
Confusion regarding cervical cancer screening and chlamydia screening among sexually active young women: Table 1
Authors: Ogbechie Oluwatobi Awele , Hacker Michele R , Dodge Laura E , Patil Mitalee Milan , Ricciotti Hope A 
Published: November 2011

ObjectiveThe American Congress of Obstetricians and Gynecologists (ACOG) recently recommended that cervical cancer screening begin at 21 years of age and occur biennially for low-risk women younger than 30 years. Earlier studies suggested that women may have limited understanding of the differences between cervical cancer screening and chlamydia screening. This study assessed the knowledge of chlamydia and cervical cancer screening tests and schedules in younger women.MethodsA survey regarding knowledge of chlamydia and cervical cancer screening was administered to 60 younger women aged 18–25 years in an obstetrics and gynaecology clinic at an urban community health centre.ResultsThe majority of respondents recalled having had a Pap smear (93.3%) or chlamydia test (75.0%). Although many respondents understood that a Pap smear checks for cervical cancer (88.3%) and human papillomavirus (68.3%), 71.7% mistakenly believed that a Pap smear screens for chlamydia. No respondent correctly identified the revised cervical cancer screening schedule, and 83.3% selected annual screening. Few respondents (23.3%) identified the annual chlamydia screening schedule and 26.7% were unsure.ConclusionMany younger women in an urban community health centre believed that cervical cancer screening also screens for chlamydia and were confused about chlamydia screening schedules. As there is limited knowledge of the revised ACOG cervical cancer screening guidelines, there is a risk that currently low chlamydia screening rates may decrease further after these new guidelines are better known. Obstetrician gynaecologists and primary care providers should educate younger women about the differences between chlamydia and cervical cancer screening and encourage sexually active younger women to have annual chlamydia screening.
Prevalent Serum Antibody Is Not a Marker of Immune Protection against Acquisition of Oncogenic HPV16 in Men
Authors: Lu Beibei , Viscidi Raphael P. , Wu Yougui , Lee Ji-Hyun , Nyitray Alan G. , Villa Luisa L. , Lazcano-Ponce Eduardo , da Silva Roberto J. Carvalho , Baggio Maria Luiza , Quiterio Manuel , Salmeron Jorge , Smith Danelle C. , Abrahamsen Martha E. , Papenfuss Mary R. , Stockwell Heather G. , Giuliano Anna R. 
Published: November 2011

Abstract
In women, naturally induced anti–human papilloma virus (HPV) serum antibodies are a likely marker of host immune protection against subsequent HPV acquisition and progression to precancerous lesions and cancers. However, it is unclear whether the same is the case in men. In this study, we assessed the risk of incident genital infection and 6-month persistent genital infection with HPV16 in relation to baseline serostatus in a cohort of 2,187 men over a 48-month period. Genital swabs were collected every 6 months and tested for HPV presence. Incidence proportions by serostatus were calculated at each study visit to examine whether potential immune protection attenuated over time. Overall, incidence proportions did not differ statistically between baseline seropositive and seronegative men at any study visit or over the follow-up period. The risk of incident and 6-month persistent infection was not associated with baseline serostatus or baseline serum antibody levels in the cohort. Our findings suggest that baseline HPV seropositivity in men is not associated with reduced risk of subsequent HPV16 acquisition. Thus, prevalent serum antibodies induced by prior infection may not be a suitable marker for subsequent immune protection against genital HPV16 acquisition in men. Cancer Res; 72(3); 676–85. ©2011 AACR.
Design, Synthesis, and Insecticidal Activity of 1,5‐Diphenyl‐1‐pentanone Analogues
Authors: Yang Shaoxiang , Kang Tieniu , Rui Changhui , Yang Xinling , Sun Yufeng , Cui Zining , Ling Yun 
Published: November 2011

AbstractThree series of novel 1,5‐diphenyl‐1‐pentanone derivatives were designed and synthesized. Their structures were characterized by IR, 1H NMR techniques, and elemental analysis. The insecticidal activities of the new compounds were preliminarily evaluated. The bioassay results indicated that the compounds X11–X30 displayed better aphicidal activity against Aphis gossypii than compounds X1–X10 and the lead compound (E)‐1,5‐diphenyl‐1‐penten‐1‐one (A). The inhibitory rates of compounds X6 and X29 were 100% against Plutella xylostella (L.) at 600 mg·L−1. Compounds X12, X13, X19, X24, X25, X26 and X27 showed higher insecticidal activity against Tetranychus cinnabarinus (Boisduval) at 600 mg·L−1 than the lead compound (A).
Mapping the morphogenetic potential of antler fields through deleting and transplanting subregions of antlerogenic periosteum in sika deer (Cervus nippon)
Authors: Gao Zhiguang , Yang Fuhe , McMahon Chris , Li Chunyi 
Published: November 2011

AbstractMorphogenetic fields are a localised and regionally regulated group of cells capable of responding to signals leading to the development of organs. In this study, we sought to determine if antlers develop from such a field. We divided antler fields into four subregions: anterior, posterior, medial and lateral. The antlerogenic periosteum (AP) in each subregion (half of the AP) was deleted and then transplanted into an ectopic site. Antlers form from the cells exclusively residing in the AP, which is located in an antler field. The morphogenetic potential of each subregion was assessed by the antler growth from both the defective field and the transplantation site. The results showed that when the AP anterior half was absent, the fields formed antlers missing the first tine, whereas when the anterior half was present, the ectopic sites regenerated antlers containing the first tine. When the medial half was deleted, the fields could only grow spike antlers, and when the medial half was present, the ectopic sites developed branched antlers. In contrast, the antler fields were able to compensate the defects caused by ablation of the posterior or the lateral half to form relatively normal antlers; and the ectopic sites containing these grafted halves only formed spike antlers. Therefore, antler morphogenetic information was primarily held in the AP anterior‐medial halves. This study substantiates the presence of morphogenetic fields in regulating the distinct pattern of antler growth, and demonstrates that antler development is a useful model for the study of morphogenetic fields.
Nonpharmacologic Intervention to Reduce Blood Pressure in Older Patients With Mild Hypertension
Authors: Applegate William B. , Miller Stephen T. , Elam Janet T. , Cushman William C. , El Derwi Douaa , Brewer Amy , Graney Marshall J. 
Published: November 2011

• Background.—Although nonpharmacologic interventions are widely recommended in the therapy of high blood pressure in older adults, surprisingly little data exist to confirm the efficacy of these interventions in older persons.Methods.—We conducted a randomized, controlled clinical trial in persons aged 60 to 85 years with a diastolic blood pressure of 85 to 100 mm Hg. The experimental arm was a nonpharmacologic intervention combining weight reduction, sodium restriction, and increased physical activity. The nonpharmacologic intervention consisted of eight weekly group and two individual sessions during the intensive phase, followed by four monthly group sessions during the maintenance phase. The control group received no treatment during the study. Blood pressure was assessed by certified technicians (blinded to group assignment) using random zero sphygmomanometers.Results.—Of 56 participants randomized, 47 completed the entire 6-month trial (21 in the intervention group and 26 in the control group). Attendance at the intervention sessions was excellent. The intervention group lost more weight (-2.1 kg) over 6 months than the control group (+0.3 kg). Trends for decreasing 24-hour urine sodium excretion in both the intervention and control groups, with greater trend in the intervention group, were not statistically significant. The intervention group experienced more reduction in systolic and diastolic blood pressure than did the control group (mean differences between groups at 6 months, 4.2/4.9 mm Hg, respectively).Conclusions.—Our data indicate that a nonpharmacologic intervention will lower systolic and diastolic blood pressure levels in older people with borderline or mild elevations of diastolic blood pressure.