bluuebunny/crossref_metadata_2025_split huggingface dataset:
Synthesis and Biological Applications of Coumarinyl-Chalcones
Authors: Ramadan Sayed K. , Rizk Sameh A. , El-Helw Eman A.E. 
Published: May 2024

Abstract:
This survey provides information on the synthesis and biological applications of
coumarinyl-chalcones. Chalcones are unsaturated ketones involving the reactive ketoethylenic
group (CO-CH=CH). Chalcones are naturally abundant in many medical plants,
including vegetables, fruits, and foods. Natural and synthetic chalcone compounds exhibit
a broad spectrum of biological properties like anticancer, anti-inflammatory, anti-HIV, antioxidant,
antimalarial, and antimicrobial. Some conventional, microwave, and grinding
techniques have been utilized for the synthesis of chalcones. Noteworthy, the Claisen-
Schmidt condensation reaction remains the most popular and effective method for synthesis.
It summarizes information about its synthetic methods as building blocks in some reactions
like cyclization reactions and medical applications. This review article presents an
overview of approaches and biological data for chalcones bearing a coumarin scaffold.
Advancements in CRISPR-Based Therapies for Genetic Modulation in Neurodegenerative Disorders
Authors: Bhushan Bharat , Singh Kuldeep , Kumar Shivendra , Bhardwaj Anjali 
Published: May 2024

:
Neurodegenerative disorders pose significant challenges in the realm of healthcare, as
these conditions manifest in complex, multifaceted ways, often attributed to genetic anomalies.
With the emergence of CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats)
technology, a new frontier has been unveiled in the quest for targeted, precise genetic manipulation.
This abstract explores the recent advancements and potential applications of CRISPR-based
therapies in addressing genetic components contributing to various neurodegenerative disorders.
The review delves into the foundational principles of CRISPR technology, highlighting its unparalleled
ability to edit genetic sequences with unprecedented precision. In addition, it talks about the
latest progress in using CRISPR to target specific genetic mutations linked to neurodegenerative
diseases like Huntington's disease, Alzheimer's disease, amyotrophic lateral sclerosis (ALS), and
Parkinson's disease. It talks about the most important studies and trials that show how well and
safely CRISPR-based therapies work. This shows how this technology can change genetic
variants that cause diseases. Notably, the discussion emphasizes the challenges and ethical considerations
associated with the implementation of CRISPR in clinical settings, including off-target effects,
delivery methods, and long-term implications. Furthermore, the article explores the
prospects and potential hurdles in the widespread application of CRISPR technology for treating
neurodegenerative disorders. It touches upon the need for continued research, improved delivery
mechanisms, and ethical frameworks to ensure responsible and equitable access to these groundbreaking
therapies.
Investigating the Effects of Urea-Zinc Sulfate-L Phenylalanine on the Corrosion Inhibition of Mild Steel Exposed to pH-4 Sulfuric Acid
Authors: Manoharan Geetha , Nithyanandam Rajesh , Antony Jenish Soosai , Rajendran Susai 
Published: May 2024

Background:
Corrosion of mild steel is a risk to material and stability. The practice of
corrosion inhibitors is a cost-effective corrosion modification method for mild steel. Organic inhibitors
rich in electrons might have an excellent ability to prevent corrosion. This study aims to assess
the inhibitory effect of the mixture of Urea, Zinc Sulfate, and L-Phenylalanine, which has a high
electron density

Methods:
MS corrosion was experimentally analyzed by dipping in H2SO4 solution at a pH – 4 for
24 hrs. Different gravimetric and conventional techniques, such as polarization, AC impedance
AFM, UV, and fluorescence, were used to examine the corrosion rate

Results:
According to gravimetric measurements, this combination produced 93% effective inhibition.
The findings of the impedance test proved that the mixture of inhibitors that was adsorbed on
the metal surface effectively prevented corrosion.

Conclusion:
Likewise, according to the Polarization measurements, the inhibitor exhibits mixed-type
performance with significant cathodic activity. UV, Fluorescence, and AFM findings showed that
MS corrosion was suppressed because the inhibitor molecule adhered to the metal's surface and reduced.
Optimizing a Classification Model to Evaluate Individual Susceptibility to Noise-induced Hearing Loss (Preprint)
Authors: Li Shiyuan , Yu Xiao , Ma Xinrong , Wang Ying , Guo Junjie , Wang Jiping , Shen Wenxin , Dong Hongyu , Salvi Richard J. , Wang Hui , Yin Shankai 
Published: May 2024

BACKGROUND

Noise-induced hearing loss (NIHL), one of the leading causes of hearing loss in young adults, is a major health care problem that has negative social and economic consequences. Among those exposed to the detrimental effects of workplace noise, some are especially vulnerable and develop NIHL after only a short time in the workplace, while other are extremely resistant and develop NIHL after many years of work.

OBJECTIVE

To determine an optimal model for detecting susceptible/resistant to NIHL and further explore phenotypic traits uniquely associated with susceptibility profiles.

METHODS

This study was performed from 2015 to 2021 at shipyards in Shanghai, China. Six methods were applied to our dataset to evaluated their classification performance. An machine learning (ML)-based diagnostic model employing frequencies from 0.25 to 12 kHz were developed to determine the most reliable frequencies, considering accuracy and area under the curve (AUC). An optimal method with most reliable frequencies was then constructed for detecting susceptible/resistant to NIHL. Phenotypic characteristics such as age, exposure time, cumulative noise exposure (CNE), and HTs, were explored for these group.

RESULTS

A total of 6276 participants (median [interquartile range (IQR)] age, 41.0 [33.0-47.0] years; 5372 [84.9%] men) were included in the analysis. An ML-based NIHL diagnostic model with misclassified subjects showed the most promising performance for identifying workers in NIHL susceptible group (NIHL-SG) and NIHL resistant group (NIHL-RG). The mean hearing thresholds (HTs) at 4 and 12.5 kHz frequencies demonstrates the highest predictive value for detecting NIHL-SG and NIHL-RG (accuracy = 0.78, AUC = 0.81). Individuals in the NIHL-SG selected by the optimized model were younger (28.0 [25.0-31.0] versus 35.0 [32.0-39.0] years old, p<0.001), with less duration of noise exposure (5.0 [2.0-8.0] versus 8.0 [4.0-12.0] years, p<0.001)and lower CNE (90.3 [85.7-92.4] versus 92.2 [89.2-94.7] dBA-year, p<0.001) but greater HTs than those in NIHL-RG (4&12.5 kHz: 58.8 [53.8-63.8] versus 8.8 [7.5-11.3] dB, p<0.001).

CONCLUSIONS

An ML-based NIHL diagnostic model with misclassified subjects, employing the mean HTs of 4 and 12.5kHz, was regarded as the most reliable method for identifying individuals susceptible or resistant to NIHL, proceeding with future studies on genetic that govern susceptibility to NIHL.

CLINICALTRIAL

This study was granted by the Institutional Ethics Review Board at Shanghai Sixth People’s Hospital affiliated with Shanghai Jiao Tong University and was registered in the Chinese Clinical Trial Registry under the identifier ChiCTR-RPC-17012580.
Lessening The Cost of Whistleblowing Through Hierarchy Peer-Reporting Type: A Grid-Group Cultural Theory Perspective
Authors: Hakami Akhmad Hafizh , Hakim Tito IM. Rahman , Muhammad Erfan 
Published: May 2024

Purpose – This study examines the moderating effect of peer-reporting type on the influence of microsocial ethical environment, anonymous reporting channel, and perceived personal cost on internal whistleblowing intentions.Methodology – This paper is an empirical study using accounting students at Trunojoyo Madura University and Bahaudin Mudhary University as respondents. By distributing an online questionnaire and using incidental sampling, 156 responses were obtained. WarpPLS software version 7.0 is used to test the hypotheses.Findings – Microsocial ethical environment and perceived personal costs have a significant effect on whistleblowing intentions. Anonymous reporting channel do not have a substantial impact on whistleblowing intentions. Peer-reporting type moderates the influence of anonymous reporting channel on whistleblowing intentions. Still, it does not significantly moderate the effect of microsocial ethical environment and the impact of perceived personal costs on whistleblowing intentions. This research also provides empirical evidence that the hierarchical dimension is a suitable policy to use to report wrongdoing among accounting students at Trunojoyo Madura University and Bahaudin Mudhary University who take forensic accounting courses.Originality – This study is among the earliest to investigate the moderation effect of peer-reporting type. A previous study based on grid-group cultural theory proposes peer-reporting type as one of the antecedents of whistleblowing intentions, albeit at the conceptual level. The present study tries to further develop this concept (peer-reporting type) as a moderating variable by transforming the peer-reporting type concept into a research instrument. Limititation/Implication – The peer-reporting type questionnaire in this research was created referring to the peer-reporting type concept proposed by the previous study. This instrument is based on the four-dimensional concept of grid-group cultural theory, which is still at the conceptual level. Therefore, the validity and reliability of this instrument need to be tested further through settings, respondents, and others research.
Development of Diffraction Research Methodologies for Mediloy S-CO Alloy Speciments Made Using LPBF Additive Manufacturing
Authors: Gadalińska Elżbieta , Malicki Maciej , Trykowska Anna , Moneta Grzegorz 
Published: May 2024

Abstract
This study focuses on the application and improvement of diffraction measurement methodologies for the optimization of manufacturing parameters of CoCr alloy components made by additive manufacturing (AM) – particularly for Mediloy S-Co alloy specimens made using Laser Powder Bed Fusion (LPBF) additive manufacturing. We measured the phase composition of specimens obtained in AM processes, the measurement of residual stresses resulting from the manufacture of these printed parts, as well as the effectiveness of stress relaxation through the use of heat treatments dedicated to this type of material. Findings reveal several insights into how printing strategies affect the porosity and residual stresses in additive manufacturing. Specimens with higher porosity, particularly those created using specific strategies that resulted in lower energy densities, exhibited lower residual stresses. Notably, printing direction and energy density were found to significantly affect the mechanical stresses within the specimens, with directional choices playing a critical role in the final properties of the parts. Additionally, our findings underscore the complex relationship between various printing parameters and the development of mechanical stresses, highlighting the impact of adjustments in printing strategy on the properties of printed components.
An unusually large superficial angiomyxoma with delayed presentation due to COVID-19: a case report
Authors: O’Hara Niall , Kolaityte Valdone , Eltigani Tigani 
Published: May 2024

Background:
Superficial angiomyxoma is a rare, benign, soft-tissue tumor. It has a non-specific presentation and there is no clear diagnostic investigation. Therefore, it is usually not suspected pre-operatively and managed incorrectly with a biopsy or narrow margin excision, which increases the recurrence rate.

Case Presentation:
A case of an unusually large superficial angiomyxoma is described with a delayed presentation to a plastic surgery clinic due to the COVID-19 pandemic. The patient was a 53-year-old male with an atraumatic 8 × 4 cm subcutaneous, mobile swelling to the left thigh. Excision was performed with no evidence of recurrence at 6 months. The mass was an uniloculated cyst with gelatinous myxoid stroma. Immunohistochemistry was positive for Alcian blue and CD34.

Conclusion:
This case report raises awareness of this rare lesion and provides a review of diagnostic aids as well as clear intra-operative photography of what a surgeon might expect when this tumor is encountered.
Percepção de sujeitos em processo de transexualização com relação a atenção e promoção dos serviços de saúde
Authors: Costa João Vitor Leme da , Paranhos Julie Stephanny de Souza Gurgel , Carvalho Beatriz Gonçalves , Souza Ana Clara Santana de 
Published: May 2024

Objetivo: Avaliar a percepção de sujeitos em processo de transexualização com relação à atenção e promoção dos serviços de saúde. Métodos: Estudo transversal, desenvolvido de forma remota, no período de junho a outubro de 2022, através de contatos telefônicos fornecidos pela instituição parceira: Casarão Brasil, localizada em São Paulo. A amostra foi composta por 28 sujeitos, com idade variando entre 22 a 52 anos e foram aplicados três questionários: 1. Questionário semi-estruturado; 2. Escala de Empatia – CARE Scale of empathy; 3. Questionário de Avaliação da Satisfação dos Usuários. Resultados: Da amostra, 96,43% declararam estar desempregados e 53,57% relataram possuir ensino médio e fundamental incompletos. Os sujeitos em processo de transexualização encontram dificuldades com relação ao acesso aos serviços de saúde, como longas esperas para marcação de consultas e para atendimentos nos serviços de saúde, despreparo dos profissionais ao atendê-los, dificuldade com o uso do nome social e patologização da transexualidade. Conclusão: Pode-se concluir, portanto, que a percepção das pessoas transexuais a respeito dos serviços de saúde é marcada pela discriminação, demora para conseguir atendimentos e falta de estrutura dos estabelecimentos.
The Current State of Intangible Cultural Heritage of Chinese-Russians of the Ergun City and the Prospects for Its Development: The Example of Folk Songs
Authors: Лян Ч. 
Published: May 2024

Статья посвящена нематериальному культурному наследию китайских русских города Эргуна Автономного района Внутренняя Монголия Китайской Народной Республики. Впервые для российских исследователей представлен весь список объектов китайских русских, принятых как на городском, так и на провинциальном и государственном уровне. Особое внимание уделено народной песне и практической работе по ее сохранению в городе Эргуна, которая является примером реализации современной культурной политики Китая, направленной на сплочение китайской нации и поддержку этнического и культурного многообразия региона.
This article is devoted to the intangible cultural heritage of the Chinese Russians in the Ergun District of Inner Mongolia, Autonomous Region of the People’s Republic of China. For the first time, it presents the entire list of Chinese- Russian cultural entities that have been recognized at city, provincial and state levels. Special attention is paid to folk songs and the practical work aimed at their preservation in the city of Erguna. This is an example of the implementation of modern Chinese cultural policy aimed both at uniting the Chinese nation and supporting ethnic and cultural diversity.
The Folk Tune “Sormach” in the Instrumental Tradition of the Nizhniy Novgorod Region: Typological Characteristics
Authors: Иванова О.В. 
Published: May 2024

Наигрыш «Сормача» занимает центральное место в инструментальной традиции Нижегородчины. Его разновидности встречаются и в других регионах России. В статье рассматриваются варианты наигрыша, зафиксированные в ходе экспедиций Московской консерватории на территории Нижегородской области начиная с 1960 г. по настоящее время. Анализируются характерные особенности «Сормача»: структура, гармоническая основа, координация текстов с инструментальным сопровождением. На примере локальных версий наигрыша затрагивается проблема типа и варианта. Впервые публикуются народные названия этого типа наигрыша, бытующего на обширной территории Поволжья и за ее пределами.
The folk tune “Sormach” has a central place in the instrumental folk tradition of the Nizhny Novgorod region and has been well studied. This article examines the variants of its instrumental form as recorded by expeditions of the Moscow Conservatory in the Nizhny Novgorod region from the 1960s to the present day. The characteristic features of “Sormach” are analyzed: its structure, harmonic basis, and the correspondence between singing and instrumental accompaniment. The problem of type and variant is discussed, based on an examination of local versions of the tune. The folk names for this type of music, practiced in the vast territory of the Volga region and beyond, are published for the first time.
Institute of Language, Literature and History, Karelian Research Centre, Russian Academy of Sciences
Authors: Марковская Е.В. 
Published: May 2024

Статья посвящена истории полевых исследований русского фольклора в Карелии. В основу исследования легли материалы фольклорного архива Карельского научного центра РАН с 1970 по 2000 г., который включает как звуковые и рукописные материалы, собранные сотрудниками Института языка, литературы и истории КарНЦ РАН, так и результаты фольклорных практик студентов Петрозаводского государственного университета и Карельского государственного педагогического института, а также материалы, поступившие от краеведов. В рассматриваемый период происходит значительное расширение области фольклора, в том числе включение в него этнографической и урбанистической составляющих. Как показал анализ научных публикаций и архивных материалов, история развития собирания фольклора рассматриваемого периода шла по нескольким главенствующим направлениям: совершенствовалась техника звукозаписи; разрабатывались новые методики, связанные с видеозаписью фольклора; все чаще использовался метод интервью; усложнились подходы к авторскому праву в отношении информанта и собирателя. Исследование показало, что архивные материалы отражают не только состояние традиции и развитие методов, использовавшихся собирателями, но и влияние исторических и политических, культурных и технологических преобразований на развитие фольклористики как в регионе, так и в стране.
This article analyzes the history of fieldwork in Karelia on Russian folklore. It is based on materials dating from 1970 to 2000 from the folklore archive of the Karelian Scientific Center of the Russian Academy of Sciences. These include audio and handwritten materials collected by employees of the Institute of Language, Literature and History of the KarSC RAS; work by students of Petrozavodsk State University and Karelian State Pedagogical Institute; and material received from local historians. During the period under review, there was a significant broadening of the field of folklore, including the incorporation of ethnographic and urban-studies elements. The author demonstrates how the collection of folklore improved by using new techniques, especially relating to the video recording of folklore. The method of interviewing grew in popularity, while issues of copyright in relation to both informant and collector became more complicated. The author suggests that archival materials reflect not only the state of tradition and changes in collectors’ methods, but also the impact of historical, cultural and technological transformations on the development of folklore, both local and nation-wide.
Faktor -Faktor Yang Berhubungan Dengan Keberhasilan Induksi Persalinan
Authors: Nur Rohmah Fayakun , Hani Edi Nawangsih Umu 
Published: May 2024

Sekitar 20-30% persalinan dilakukan melalui proses induksi persalinan. Induksi dilakukan untuk mengurangi mortalitas pada ibu dan morbiditas baik ibu mapun janin. Beberapa permasalahan pada ibu dapat timbul pada saat atau setelah induksi persalinan, persalinan dengan induksi persalinan meningkatkan resiko 1 kali terjadi perdarahan pada ibu bersalin. Keberhasilan induksi persalinan dipengaruhi oleh beberapa faktor yaitu: paritas, skor bishop, umur ibu dan umur kehamilan. Penelitian ini bertujuan untuk menggambarkan karakeristik ibu, jenis induksi dan keberhasilan induksi. Penelitian dilakukan di RSKIA PKU Muhammadiyah Kotagede, dengan jumlah sampel 93 ibu bersalin yang dipilih dengan teknik purposive sampling. Data diambil secara retrospektif dari rekam medis pasien. Hasil penelitian menunjukkan sebagian besar ibu yang bersalin dengan induksi berumur 20-35 tahun yaitu 76%, dengan paritas primipara. Mayoritas induksi dilakukan dengan pemberian oksitosin (81%) dan keberhasilan induksi sebesar 68%.
Perbedaan Fungsi Kognitif Lansia Di Tinjau Dari Tempat Tinggal
Authors: Untung Ida untari , Untari Dita Tri Susilowati , Untari Siti Sarifah 
Published: May 2024

Sindrom geriatrie urutan nomor 2 adalah penurunan fungsi kognitif. Fungsi kognitif diperlukan lansia dalam kemampuannya dalam beraktivitas sehari-hari. Penurunan fungsi kognitif, jika dibiarkan tanpa perawatan akan menurunkan kuliatas hidup lansia. Faktor-faktor yang mempengaruhi penurunan fungsi kognitif pada lansia adalah perubahan fisik, kesehatan umum, tingkat pendidikan dan lingkungan. Tujuan penelitian ini menganalisis perbedaan fungsi kognitif lansia di tinjau dari tempat tinggal. Metode penelitian yang digunakan berupa analitik komparatif, dengan mengambil populasi lansia di desa Komplang RW 26 Kadipiro Surakarta dan Panti Jompo Aisyiyah Surakarta pada bulan Januari 2018 - Februari 2018. Menggunakan teknik purposive sampling mendapatkan 46 responden. Instrumen pengukuran fungsi kognitif menggunakan MMSE dengan analisis menggunakan uji Mann-Whitney pada signifikan 5%. Ada perbedaan fungsi kognitif lansia ditinjau dari tempat tinggal dengan nilai p= 0.000 dimana lansia yang bersama keluarga mempunyai fungsi kognitif lebih baik daripada lansia yang berada di Panti Jompo.
Analysis Of Factors Affecting Interest Kai Access Application Users Using Models Unified Theory Of Acceptance And Use Of Technology 2 (UTAUT 2)
Authors: Firmansyah Rifki , Fauziah Yuli , Perwira Rifki Indra 
Published: May 2024

Purpose: This study aims to analyze the factors that influence user interest in the KAI Access application using the Unified Theory Of Acceptance And Use Of Technology 2 (UTAUT 2) model.Methodology: This study used the Structural Equation Modeling (SEM) method with two tests, namely the outer model and the inner model with the help of the SmartPLS Version 3 software. A total of 406 respondent data were used from the Special Region of Yogyakarta and also users of the KAI Access application.Results: The results of the study show that of the fourteen hypotheses proposed in the study, only seven were accepted, namely social influence, facilitating conditions, hedonic motivation, price value, and habit. The strongest factors that have a significant effect are hedonic motivation and habit.State of the art: based on previous research, this study has quite similar characteristics but different cases, variables, and research samples.