bluuebunny/crossref_metadata_2025_split huggingface dataset:
Single-cell transcriptomics and Mendelian randomization reveal LUCAT1’s role in right-sided colorectal cancer risk
Authors: Shang Zhihao , Xi Songyang , Lai Yueyang , Cheng Haibo 
Published: April 2024

Background: Colorectal cancer (CRC) is a malignancy with high incidence and mortality rates globally, categorized into left-sided and right-sided CRC, each exhibiting significant differences in molecular characteristics, clinical manifestations, and prognosis.Methods: This study employed single-cell transcriptomic data and various bioinformatics approaches, such as two-sample Mendelian randomization, reverse Mendelian randomization, colocalization analysis, directed filtering, pseudotime analysis, and intercellular communication analysis. It analyzed cellular-level disparities between left-sided and right-sided CRC, identifying distinct subpopulations with characteristic variations. For these cells, two-sample Mendelian randomization was utilized to explore gene-to-one-sided CRC causality.Results: LUCAT1 was enriched in high-abundance monocyte subpopulations in right-sided CRC and demonstrated potential risk factor status through Mendelian randomization analysis. The specific single-nucleotide polymorphism (SNP) rs10774624 was associated with an increased risk of CRC. Moreover, metabolic pathway analysis revealed that LUCAT1+ monocytes exhibit lower communication activity in the tumor microenvironment and heightened activity in metabolic functions like glycosaminoglycan degradation. Its biological functions are related to the positive regulation of interleukin-6 production and NF-kappa B signaling, among others.Conclusion: This study confirmed a potential causal relationship between LUCAT1 and right-sided CRC risk through Mendelian randomization analysis. These findings provide novel insights into the pathogenesis of right-sided CRC and may aid in developing early detection and treatment strategies for right-sided CRC.
The top 100 most cited articles in the past 30 years of wheat allergy: a bibliometric analysis
Authors: Zhan Mengyuan , Hou Yibo , Wen Liping , Xu Tengda 
Published: April 2024

BackgroundWheat allergy (WA), characterized by immunological responses to wheat proteins, is a gluten-related disorder that has become increasingly recognized in recent years. Bibliometrics involves the quantitative assessment of publications within a specific academic domain.ObjectivesWe aimed to execute an extensive bibliometric study, focusing on the past 30 years of literature related to wheat allergy.MethodsWe searched the Web of Science database on 5th Dec 2023. We used the keywords “wheat allergy or wheat anaphylaxis or wheat hypersensitivity,” “gliadin allergy or gliadin anaphylaxis or gliadin hypersensitivity,” “wheat-dependent exercise-induced anaphylaxis,” and “baker's asthma” for our search. All items published between 1993 and 2023 were included. The top 100 most cited articles were identified and analyzed.ResultsOur study conducted an in-depth bibliometric analysis of the 100 most-cited articles in the field of wheat allergy, published between 2002 and 2019. These articles originated from 20 different countries, predominantly Japan and Germany. The majority of these articles were centered on the pathogenesis and treatment of wheat allergy (WA). The Journal of Allergy and Clinical Immunology (JACI) was the most prolific contributor to this list, publishing 14 articles. The article with the highest citation count was published by Biomed Central (BMC) and garnered 748 citations. The peak citation year was 2015, with a total of 774 citations, while the years 1998, 2001, and 2005 saw the highest publication frequency, each with 7 articles.ConclusionOur study aims to provide physicians and researchers with a historical perspective for the scientific progress of wheat allergy, and help clinicians effectively obtain useful articles that have a significant impact on the field of wheat allergy.
Correlation between serum leptin level and sleep monitoring indexes in patients with obstructive sleep apnea hypopnea syndrome and its predictive value: a cross-sectional analysis
Authors: Li Ji , Zhou Kejing , Chen Xing , Lu Xu , Kong Deqiu 
Published: April 2024

ObjectiveTo investigate the association between serum leptin (LP) level and polysomnography (PSG) parameters in patients with obstructive sleep apnea hypopnea syndrome (OSAHS).MethodsA cross-sectional study was conducted. The data of subjects who underwent PSG at hospital between January 2021 and December 2022 were collected retrospectively, 220 participants were included. The subjects were categorized into simple snoring group (n = 45), mild OSAHS group (n = 63), moderate OSAHS group (n = 52), and severe OSAHS group (n = 60). The general characteristics, PSG indices, and serological indices were collected retrospectively. Pearson correlation analysis was used to observe the correlation between serum LP level and PSG parameters. The value of serum LP level in predicting OSAHS was analyzed by receiver operating characteristic curve.ResultsThe serum LP level was positively correlated with micro-arousal count, micro-arousal index (MAI), high apnea hypopnea index, times of blood oxygen decreased by≥3% and time in saturation lower 90%, and negatively correlated with lowest nocturnal oxygen saturation and mean oxygen saturation (p &lt; 0.05). The area under the curve (AUC) of serum LP level in predicting the occurrence of OSAHS was 0.8276 (95% CI: 0.7713–0.8839), and when the Youden index was 0.587, the sensitivity was 72.00%, and the specificity was 86.67% (p &lt; 0.0001). In the population with high MAI, the AUC of serum LP level in predicting the occurrence of OSAHS was 0.8825 (95% CI: 0.7833–0.9817), and when the Youden index was 0.690, the sensitivity was 79.00% and the specificity was 90.00% (p &lt; 0.0001).ConclusionSerum LP level is associated with the severity of OSAHS. Serum LP level demonstrates a strong predictive value for the occurrence of OSAHS, particularly in population with high MAI.
Exploring the link between obesity and hypothyroidism in autoimmune thyroid diseases: a metabolic perspective
Authors: Jing Mengzhe , Shao Shanshan , Ma Shizhan , Gao Ling , Wang Qian , Zhou Meng 
Published: April 2024

Background: The management of primary hypothyroidism demands a comprehensive approach that encompasses both the implications of autoimmune thyroid disease and the distinct effects posed by obesity and metabolic irregularities. Despite its clinical importance, the interplay between obesity and hypothyroidism, especially in the context of metabolic perspectives, is insufficiently explored in existing research. This study endeavors to classify hypothyroidism by considering the presence of autoimmune thyroid disease and to examine its correlation with various metabolic obesity phenotypes.Method: This research was conducted by analyzing data from 1,170 individuals enrolled in the Thyroid Disease Database of Shandong Provincial Hospital. We assessed four distinct metabolic health statuses among the participants: Metabolically Healthy No Obese Metabolically Healthy Obese Metabolically Unhealthy No Obese and Metabolically Unhealthy Obese Utilizing logistic regression, we investigated the association between various metabolic obesity phenotypes and hypothyroidism.Results: The study revealed a significant correlation between the Metabolically Unhealthy Obese (MUO) phenotype and hypothyroidism, particularly among women who do not have thyroid autoimmunity. Notably, the Metabolically Unhealthy No Obese (MUNO) phenotype showed a significant association with hypothyroidism in individuals with thyroid autoimmunity, with a pronounced prevalence in women. Furthermore, elevated levels of triglycerides and blood glucose were found to be significantly associated with hypothyroidism in men with thyroid autoimmunity and in women without thyroid autoimmunity.Conclusion: Effective treatment of hypothyroidism requires a thorough understanding of the process of thyroid autoimmune development. In patients without concurrent thyroid autoimmunity, there is a notable correlation between obesity and metabolic issues with reduced thyroid function. Conversely, for patients with thyroid autoimmunity, a focused approach on managing metabolic abnormalities, especially triglyceride levels, is crucial.
Effectiveness of tranexamic acid on chronic subdural hematoma recurrence: a meta-analysis and systematic review
Authors: Pan Wani , Hu Jinyang , Huang Xin , Jin Erlang , Yao Longfei , Han Jing , Liu Tiantian 
Published: April 2024

ObjectivesOur objective was to compare the effectiveness of TXA in improving recurrence in patients with chronic subdural hematoma (CSDH).MethodsEligible randomized controlled trials (RCTs), prospective trials and retrospective cohort studies were searched in PubMed, Cochrane Library, Embase, and CNKI from database inception to December 2023. After the available studies following inclusion and exclusion criteria were screened, the main outcome measures were strictly extracted. Reman v5.4. was used to assess the overall recurrence rate. A random-effects model was used to assess pooled ORs, with the Mantel–Haenszel estimation method applied. Cochran Q (Chi-square) test and I2 statistics were used to assess inter-study heterogeneity. Funnel plots were used to evaluate publication bias.ResultsFrom the 141 articles found during initial citation screening, 9 literatures were ultimately included in our study. Our NMA results illustrated that patients with newly diagnosed Chronic subdural hematoma revealed a significantly improved recurrence rate when patients were treated with Tranexamic acid (OR: 0.33; 95% CI 0.26–0.41; p &lt; 0.00001) compared with standard neurosurgical treatment. There was no significant difference in the incidence rates of thrombosis (OR: 0.84; 95% CI 0.63–1.12; p = 0.23) and mortality (OR: 1.0; 95% CI 0.57–11.76; p = 0.99), Occurrence of myocardial infarction was significantly less frequent in TXA users than in nonusers (OR: 0.18; 95% CI 0.04–0.82; p = 0.03).ConclusionTXA can effectively improve the recurrence rate of CDSH. It provides a high level of evidence-based medicine for clinical treatment. In addition, multicenter randomized controlled trials, with dose adjustments, are still needed to determine whether TXA intervention improves neurological function or prognosis.
Efficacy of repetitive transcranial magnetic stimulation in post-stroke cognitive impairment: an overview of systematic reviews
Authors: Zhang Linli , Gao Shan , Wang Chengshuo , Li Yuanyuan , Yuan Huateng , Cao Longjun , Gao Chong 
Published: April 2024

ObjectiveThe reliability of clinical evidence depends on high-quality meta-analyses/ systematic reviews (MAs/SRs). However, there has been no assessment of the quality of MAs/SRs for repetitive transcranial magnetic stimulation (rTMS) in post-stroke cognitive impairment (PSCI), both nationally and internationally. This article seeks to use radar plotting to visually present the quality of MAs/SRs on rTMS for improving cognitive function in PSCI, aiming to offer an intuitive foundation for clinical research.MethodsEight Chinese or English databases were systematically searched to collect comprehensive literature, and the retrieval time ranged from inception to 26 March 2024. Literature ranking was calculated using six dimensions: publication year, design type, AMSTAR-2 score, PRISMA score, publication bias, and homogeneity. Finally, radar plots were drafted to present a multivariate literature evaluation. The GRADE tool assessed the strength of evidence for the outcome indicators included in the MAs/SRs.ResultsThe 17 articles included had average scores of 12.29, 17, 9.88, 9.71, 12.88, and 12.76 for each dimension. The radar plot showed that an article published in 2023 had the highest rank and a large radar plot area, while an article published in 2021 had the lowest rank and a small radar plot area. The GRADE tool evaluation revealed that 51 pieces of evidence were of very low quality, 67 were of low quality, 12 were of moderate quality, and only one was of high quality.ConclusionThe average rank score of literature ranged from 8.50 to 17, with higher rankings indicating greater significance in literature reference. Variations in literature quality were attributed to inadequate study planning, irregular literature search and screening, insufficient description of inclusion criteria for studies, and inadequate consideration of bias risk in the included studies. Most MAs/SRs indicated that rTMS was more effective than the control group in enhancing the global cognitive function and activities of daily living in PSCI patients. However, the overall quality of the literature was generally low and needs validation from future high-quality evidence.Systematic review registration:https://www.crd.york.ac.uk/prospero/, identifier CRD42023491280.
Changing trends in the disease burden of uterine cancer globally from 1990 to 2019 and its predicted level in 25 years
Authors: Song Shuang , Zhang Dandan , Wang Yizi , Song Zixuan 
Published: April 2024

BackgroundWe aim to evaluate the global, regional, and national burden of Uterine Cancer (UC) from 1990 to 2019.MethodsWe gathered UC data across 204 countries and regions for the period 1990-2019, utilizing the Global Burden of Disease Database (GBD) 2019 public dataset. Joinpoint regression analysis was employed to pinpoint the year of the most significant changes in global trends. To project the UC trajectory from 2020 to 2044, we applied the Nordpred analysis, extrapolating based on the average trend observed in the data. Furthermore, the Bayesian Age-Period-Cohort (BAPC) model with integrated nested Laplace approximations was implemented to confirm the stability of the Nordpred analysis predictions.ResultsGlobally, the age-standardized rate (ASR) of incidence for UC has increased from 1990 to 2019 with an Average Annual Percentage Change (AAPC) of 0.50%. The ASR for death has declined within the same period (AAPC: -0.8%). An increase in the ASR of incidence was observed across all Socio-demographic Index (SDI) regions, particularly in High SDI regions (AAPC: 1.12%), while the ASR for death decreased in all but the Low SDI regions. Over the past 30 years, the highest incidence rate was observed in individuals aged 55-59 (AAPC: 0.76%). Among 204 countries and regions, there was an increase in the ASR of incidence in 165 countries and an increase in the ASR of deaths in 77 countries. Our projections suggest that both the incidence and death rates for UC are likely to continue their decline from 2020 to 2044.ConclusionsUC has significantly impacted global health negatively, with its influence stemming from a range of factors including geographical location, age-related and racial disparities, and SDI.
Clinical exome sequencing by general pediatricians: high clinical utility and no evidence of inappropriate testing
Authors: Baz Danya Salah , Baz Dareen , Alrwuili Fawzah , Aldowaish Abdullah , Shamseldin Hanan E. , Elhomoudi Ayman , Alkuraya Fowzan S. 
Published: April 2024

BackgroundGenetic disorders account for a large percentage of admissions and outpatient visits to children's hospitals around the world. Clinical exome sequencing (CES) is a valuable diagnostic tool in the workup of these disorders; however, it is not routinely requested by general pediatricians. This may represent a missed opportunity to increase patient access to this powerful diagnostic tool. In our institution, general pediatricians can directly order CES. In this context, this study aims to evaluate the appropriateness of CES and its clinical utility when ordered by general pediatricians.MethodsWe retrospectively reviewed all CES tests ordered by general pediatricians in our institution between 2019 and 2023 and recorded their indications and results. General pediatricians were interviewed to evaluate how CES impacted the domains of clinical utility by assessing changes in management, communication, subsequent testing, and counseling. In addition, feedback was obtained, and barriers faced by general pediatricians to order CES were assessed.ResultsThe study cohort (n = 30) included children from the inpatient (60%) and outpatient (40%) departments. A positive finding (a pathogenic or likely pathogenic variant that explains the phenotype) was observed in 11 of 30 cases (37%), while 3 (10%) and 16 (53%) received ambiguous (variant of uncertain significance) and negative results, respectively. The indication was deemed appropriate in all 30 cases (100%). Clinical utility was reported in all 11 positive cases (100%). Reproductive counseling is a notable utility in this highly consanguineous population, as all variants identified, in the 11 positive cases, were autosomal recessive.ConclusionWe show that CES ordered by general pediatricians is appropriately indicated and provides a diagnostic yield comparable to that requested by specialists. In addition, we note the high clinical utility of positive results as judged by the ordering pediatricians. The findings of this study can empower general pediatricians to advocate for expanded CES adoption to improve patient access and shorten their diagnostic odyssey.
Design, synthesis, molecular docking, and molecular dynamic studies of novel quinazoline derivatives as phosphodiesterase 7 inhibitors
Authors: El-Malah Afaf A. , Gineinah Magdy M. , Khayat Maan T. , Aljahdali Anfal S. , Safar Marwa M. , Almazmumi Hadeel A. , Khinkar Roaa M. 
Published: April 2024

Introduction: Phosphodiesterase 7 (PDE7) is a high-affinity cyclic AMP (cAMP)-specific PDE that is expressed in immune and proinflammatory cells. In this work, we explore the possibility that selective small molecule inhibitors of this enzyme family could provide a novel approach to alleviate the inflammation that is associated with many inflammatory diseases.Methods: A series of novel substituted 4-hydrazinoquinazoline derivatives and fused triazoloquinazolines were designed, synthesized, and evaluated in vitro for their PDE7A inhibition activities, in comparison with Theophylline, a non-selective PDE inhibitor, and BRL50481, a selective PDE7A inhibitor. This series of novel quinazoline derivatives were synthesized via multi-step reactions. The reaction sequence began with selective monohydrazinolysis of compounds 2a,b to give 3a,b. Schiff bases 4a-h were synthesized by the reaction of the quinazolylhydrazines 3a,b with various substituted aromatic aldehydes. The reaction of 4a-h with bromine in acetic acid, in turn, gave fused triazoloquinazolines 5a-h. These compounds were characterized by satisfied spectrum analyses mainly including 1HNMR, 13CNMR, and MS together with elemental analyses.Results and discussion: The results of in vitro PDE7A inhibition activity clearly indicated that compounds 4b, 4g, 5c, and 5f exhibited good potency. Molecular docking and molecular dynamic simulation studies further supported our findings and provided the basis of interaction in terms of conventional hydrogen bonds and π-π stacking patterns. The present results lay the groundwork for developing lead compounds with improved phosphodiesterase seven inhibitory activities.
LogMS: a multi-stage log anomaly detection method based on multi-source information fusion and probability label estimation
Authors: Yu Zhongjiang , Yang Shaoping , Li Zhongtai , Li Ligang , Luo Hui , Yang Fan 
Published: April 2024

Introduction: Log anomaly detection is essential for monitoring and maintaining the normal operation of systems. With the rapid development and maturation of deep learning technologies, deep learning-based log anomaly detection has become a prominent research area. However, existing methods primarily concentrate on directly detecting log data in a single stage using specific anomaly information, such as log sequential information or log semantic information. This leads to a limited understanding of log data, resulting in low detection accuracy and poor model robustness.Methods: To tackle this challenge, we propose LogMS, a multi-stage log anomaly detection method based on multi-source information fusion and probability label estimation. Before anomaly detection, the logs undergo parsing and vectorization to capture semantic information. Subsequently, we propose a multi-source information fusion-based long short-term memory (MSIF-LSTM) network for the initial stage of anomaly log detection. By fusing semantic information, sequential information, and quantitative information, MSIF-LSTM enhances the anomaly detection capability. Furthermore, we introduce a probability label estimation-based gate recurrent unit (PLE-GRU) network, which leverages easily obtainable normal log labels to construct pseudo-labeled data and train a GRU for further detection. PLE-GRU enhances the detection capability from the perspective of label information. To ensure the overall efficiency of the LogMS, the second-stage will only be activated when anomalies are not detected in the first stage.Results and Discussion: Experimental results demonstrate that LogMS outperforms baseline models across various log anomaly detection datasets, exhibiting superior performance in robustness testing.
The dynamic nature of parenting practices: a qualitative enquiry of parenting adolescents during COVID-19
Authors: Babu Nandita , Fatima Mehreen , Arora Manushi 
Published: April 2024

IntroductionParenting practices are known to be dynamic, evolving in response to various factors such as societal changes, cultural norms, and individual circumstances. Understanding the dynamic nature of parenting is essential for comprehending its influence on children’s development. This study aimed to explore the adaptive nature of parenting practices amidst the backdrop of the COVID-19 pandemic, a global event that provided a unique context for examining these dynamics.MethodsIn-depth semi-structured qualitative interviews were conducted with six heterogeneous couples who were parenting at least one adolescent during the pandemic. Attride-Sterling’s thematic network analysis was employed to analyze the interview data.ResultsFive global themes emerged from the data, namely, change in parenting style due to stressors, paternal versus maternal style of parenting, intergenerational transmission of parenting practices, child-centric parenting practices, positive parenting practices and evolving parent–child relationship during COVID-19.DiscussionThe findings highlight the tendency of parents to adapt their parenting styles to meet the evolving needs of their children. Understanding these dynamics is crucial for supporting families during times of crisis. Future research should explore the long-term effects of these changes and effective strategies for promoting positive parent-child relationships.
The effect of student-perceived teacher support on math anxiety: chain mediation of teacher–student relationship and math self-efficacy
Authors: Wang Chao , Xu Qing , Fei Wei-qun 
Published: April 2024

IntroductionThis study investigates the mechanisms linking students’ perceived teacher support with math anxiety, focusing on the mediating roles of the teacher–student relationship and mathematics self-efficacy.MethodsThe research was conducted with 401 fifth-grade students in China, utilizing scales for Students’ Perceived Teacher Support, Teacher–Student Relationship, Math Self-Efficacy, and Math Anxiety.ResultsFindings revealed that student-perceived math teacher support, teacher–student relationship, and math self-efficacy were all significantly negatively correlated with math anxiety. It was notably found that student-perceived math teacher support influenced math anxiety through the chain mediation of teacher–student relationship and math self-efficacy. Additionally, the effect of students’ perceived emotional support from math teachers on math anxiety, mediated by teacher–student relationship intimacy, was significant only among male students.DiscussionThese results underscore the importance of fostering positive teacher–student interactions and enhancing self-efficacy to reduce math anxiety among primary school students. The gender-specific findings regarding emotional support and relationship intimacy highlight the need for tailored strategies in addressing math anxiety.