bluuebunny/crossref_metadata_2025_split huggingface dataset:
Challenges in blood transfusion caused by anti-Hr0: A rare case of D-- Phenotype in Asia Abstract
Authors: Luo Yuanyuan , Ma Chunya , Fu Lihui , Yu Yang 
Published: May 2024

Abstract
Introduction
D–Phenotype is linked to abnormal expression of RHCE gene. Consequently, individuals with this condition may develop antibodies against high-prevalence Rh antigens when exposed to a normal Rh phenotype, leading to challenges in blood matching.

Case presentation
A 90-year-old male was admitted to the hospital due to prostatitis and acute retention of urinary. Surgery was planned after evaluation by urologist. A request was made for 2 units of red blood cells (RBC). The result for unexpected antibody screening was positive, and the antibody was identified as anti-Hr0 alloantibody , a rare RHCE * CE-D (5) – CE was discovered by genetic testing. The patient has only one history of blood transfusion, which may result in the production of the anti-Hr0 antibody. Compatible blood donors for this patient were not found, even after extensive screening.

Conclusion
This report records a rare case of a D-- phenotype individual who produced anti-Hr0 alloantibody. Subsequent analysis of RH gene sequencing revealed a genotype that has not been previously reported in Asia.
Feasibility, acceptability and preliminary effect of a community-led HIV self-testing model among adolescent girls and young women in Rural Northern Uganda: a quasi-experimental study protocol
Authors: Olum Ronald , Geng Elvin H. , Kitutu Freddy E. , Musoke Philippa M. 
Published: May 2024

Abstract
Background
Adolescent girls and young women (AGYW) in sub-Saharan Africa face a disproportionately higher HIV/AIDS burden despite the global decline in incidence. Existing interventions often fail to adequately address their unique social, economic, and cultural challenges, limiting access to essential HIV/AIDS services, including HIV testing. Emerging evidence indicates that HIV self-testing, a user-friendly and confidential method, enhances HIV diagnosis and linkage to care by targeting these barriers. This study aims to assess the feasibility, acceptability, and preliminary impact of a peer-delivered, community-health worker (CHW)-facilitated HIV self-testing intervention for AGYW in Northern Uganda.

Methods
This mixed-methods quasi-experimental implementation science study will employ a three-fold approach. Firstly, we will conduct baseline formative qualitative research with 50 AGYW, 50 parents/partners to AGYW, 30 CHWs, 15 community leaders, and the district health office to inform the design of a peer-delivered CHW-facilitated HIV self-testing intervention tailored to AGYW’s needs in Northern Uganda. Secondly, we will implement a mixed-methods pilot study to assess the intervention’s feasibility and acceptability, involving 415 AGYW, 30 AGYW peer leaders, and 10 CHWs in selected parishes and villages in Omoro district, Northern Uganda. Lastly, we will evaluate the implementation outcomes and preliminary impact of the intervention on HIV self-testing rates and linkage to care by collecting and analyzing quantitative data pre- and post-intervention, laying the groundwork for a future robust randomized controlled trial.

Discussion
Our intervention combines CHWs and peer-led strategies to address the unique challenges of AGYW in Northern Uganda, leveraging community resilience and peer influence. Successful completion of this project will provide a scalable model to be evaluated in a randomized trial and replicated in similar contexts.

Trial registration number
PACTR202404851907736. Registered with the Pan-African Clinical Trials Registry on April 22, 2024.
Early maladaptive schemas, distress tolerance and self-injury in Iranian adolescents: serial mediation model of transdiagnostic factors
Authors: Babaeifard Maryam , Akbari Mehdi , Mohammadkhani Shahram , Hasani Jafar , Shahbazian Reza , Selby Edward A. 
Published: May 2024

BackgroundNon-suicidal self-injury (NSSI) is prevalent behaviour among adolescents. Although there are different etiological models of NSSI, there is a general lack of evidence-based, comprehensive and transdiagnostic models of NSSI in adolescents.AimsThe aim of this study was to investigate a model of transdiagnostic factors of NSSI in adolescents, testing a serial mediation model of the relationship between early maladaptive schemas (EMS), distress tolerance and NSSI through experiential avoidance and rumination.MethodA community sample was identified of 1014 adolescents aged 13–17, of whom 425 had a history of NSSI. A serial mediation path analytic method was utilised to examine the relationships between NSSI and its associated functions as criterion variables, EMS and distress tolerance as predictors, experiential avoidance as the first mediator and rumination as the second mediator.ResultsThe path analytic model fit indices were good (X2/d.f. = 2.25, goodness of fit index = 0.98, normed fit index = 0.97, comparative fit index = 0.98, root mean square error of approximation = 0.054, standardised root mean squared residual = 0.028). Rumination significantly mediated the relationship between schemas of ‘vulnerability to harm’, ‘emotional deprivation’, ‘social isolation’, ‘insufficient self-control’, and NSSI frequency and intrapersonal functions. In serial fashion, experiential avoidance mediated the role of rumination in the relationship between social isolation, and insufficient self-control and NSSI frequency and intrapersonal functions. All indirect effects were significant.ConclusionsKey indirect effects were found linking maladaptive schemas and distress tolerance to NSSI frequency, and NSSI intrapersonal functions via experiential avoidance and rumination. Thus, it is important to address these transdiagnostic factors with particular emphasis on the sequential mediating role of experiential avoidance and rumination in conceptualisation and therapeutic interventions for NSSI.
Spin-orbit torque-driven domain wall motion in the absence of Dzyaloshinskii-Moriya interactions
Authors: Thiaville André , Miltat Jacques 
Published: May 2024

Abstract
The fine structure and dynamics of magnetic domain walls in ultrathin films with perpendicular magnetization, in the presence of a secondary anisotropy, is analysed owing to micromagnetics. Two cases are considered, a cubic anisotropy typical for (111) oriented garnet epitaxial films, and an orthorhombic anisotropy as found in, e.g., Co/W(110) films. The statics is solved first, showing that, in general, domain walls are not of the pure Bloch type. The dynamics under the spin Hall effect induced by a current flowing in an adjacent layer is then monitored. Finite and non-negligible domain wall velocities are predicted in both cases, in the absence of Dzyaloshinskii-Moriya interactions, with distinct behaviours regarding the current density and its orientation with respect to the secondary anisotropy axes. The relevance of these results to recent reports of current-driven domain wall dynamics in insulating ultrathin garnet films, capped with platinum, is discussed.
Gender-Affirming Treatment and Employment Rate in 3812 Danish Transgender Persons and 38 120 Controls
Authors: Glintborg Dorte , Møller Jens-Jakob Kjer , Rubin Katrine Hass , Lidegaard Øjvind , T’Sjoen Guy , Larsen Mie-Louise Julie Ørsted , Hilden Malene , Andersen Marianne Skovsager 
Published: May 2024

Abstract

Objective
Gender-affirming care could be associated with higher employment rate. We assessed employment rates in transgender persons compared to controls and demographic, health, and treatment-related factors associated with employment in transgender persons.

Methods
National register-based cohort study in Danish persons with diagnosis code of gender dysphoria during year 2000-2021. Five age-matched controls of the same sex at birth and 5 age-matched controls of the other sex at birth were included. The date of study inclusion was the first date of transgender diagnosis. Employment was the primary study outcome.

Results
The cohort included 3812 transgender persons and 38 120 cisgender controls. The median age (interquartile range) was 19 (15; 24) years for transgender men, n = 1993 and 23 (19; 33) years for transgender women, n = 1819. In transgender men compared to control cisgender women, the odds ratio (OR) (95% CI) for employment was 0.33 (0.29; 0.38) before study inclusion and 0.24 (0.20; 0.29) in the fifth calendar year after index; in transgender women compared to control cisgender men, corresponding ORs were 0.30 (0.70; 0.34) and 0.21 (0.18; 0.25). Similar findings were observed between transgender persons and cisgender controls of other sex. Use of gender-affirming hormone in transgender men increased probability of employment at all time points after 5 years (OR 1.61 [95% CI: 1.08; 2.42], P = .02). In transgender women, use of hormone treatment was not associated with changed employment rates at 5 years (OR 1.31 [0.94; 1.82], P = .11).

Conclusion
Masculinizing hormone treatment was associated with higher probability of employment.
Reassessing Chronic Strain: A Research Note on Women's Income Dynamics After Divorce and Separation
Authors: Leopold Thomas , Kalmijn Matthijs 
Published: May 2024

Abstract
The economic consequences of divorce and separation for women are commonly associated with the chronic strain model, according to which women's losses are large and persistent. This research note shifts the focus to a crisis model highlighting women's potential of, and routes to, recovery from initial losses. Drawing on German Socio-Economic Panel data (1984–2021) on women in marital and cohabiting unions (N ∼ 27,000 women, N ∼ 3,400 divorces and separations), we use fixed-effects regression models and event-history models to analyze changes in equivalized monthly household income and poverty risk across the process of divorce and separation. Results show that most women recovered from their initial economic declines. Although initial losses were common and often sizable, large fractions of women eventually returned to or exceeded the household income expected in the absence of divorce and separation. Recovery was facilitated by the “traditional” route of repartnering and the “modern” route of women mobilizing their productive skills. Both routes appeared more important than the absence of barriers, such as children in the household. We conclude that for the majority of women, the economic consequences of divorce and separation are better described as a temporary crisis than as a chronic strain.
Endothelial HIF2α suppresses retinal angiogenesis in neonatal mice by upregulating NOTCH signaling
Authors: Duan Li-Juan , Jiang Yida , Fong Guo-Hua 
Published: May 2024

ABSTRACT
Prolyl hydroxylase domain (PHD) proteins are oxygen sensors that use intracellular oxygen as a substrate to hydroxylate hypoxia-inducible factor (HIF) α proteins, routing them for polyubiquitylation and proteasomal degradation. Typically, HIFα accumulation in hypoxic or PHD-deficient tissues leads to upregulated angiogenesis. Here, we report unexpected retinal phenotypes associated with endothelial cell (EC)-specific gene targeting of Phd2 (Egln1) and Hif2alpha (Epas1). EC-specific Phd2 disruption suppressed retinal angiogenesis, despite HIFα accumulation and VEGFA upregulation. Suppressed retinal angiogenesis was observed both in development and in the oxygen-induced retinopathy (OIR) model. On the other hand, EC-specific deletion of Hif1alpha (Hif1a), Hif2alpha, or both did not affect retinal vascular morphogenesis. Strikingly, retinal angiogenesis appeared normal in mice double-deficient for endothelial PHD2 and HIF2α. In PHD2-deficient retinal vasculature, delta-like 4 (DLL4, a NOTCH ligand) and HEY2 (a NOTCH target) were upregulated by HIF2α-dependent mechanisms. Inhibition of NOTCH signaling by a chemical inhibitor or DLL4 antibody partially rescued retinal angiogenesis. Taken together, our data demonstrate that HIF2α accumulation in retinal ECs inhibits rather than stimulates retinal angiogenesis, in part by upregulating DLL4 expression and NOTCH signaling.
Publicly Traded Debt Restructuring Methods, Corporate Investment, and Debt Contracting
Authors: Fan Xin 
Published: May 2024

I use an important ruling, Marblegate Asset Management v. Education Management Corporation (EMC), to study the economic role of two publicly traded debt restructuring methods: coercive bond exchange offers and Chapter 11. This ruling restricted firms from employing coercive bond exchange offers to facilitate out-of-court restructurings, thereby increasing the likelihood of restructuring publicly traded debt under Chapter 11. Following the ruling, investment in affected distressed firms decreased substantially, but investment efficiency improved. The changes in covenant, maturity, and offering yield of newly issued bonds suggested that existing bondholders with covenants gained more bargaining power than shareholders and new bondholders. The paper provides causal evidence from a large sample analysis, demonstrating the divergent effects of these two publicly traded debt restructuring methods on investment policies. This paper was accepted by Victoria Ivashina, finance. Funding: Funding for this research was provided by University of Pittsburgh (Doctoral Fellowship) and Vanderbilt University (standard research funds). Supplemental Material: The online appendix and data files are available at https://doi.org/10.1287/mnsc.2022.01831 .
Reactive oxygen species in endothelial signaling in COVID-19: Protective role of the novel peptide PIP-2
Authors: Paul Oindrila , Akolia Isha K. , Qin Tao Jian , Jain Nikita , Louneva Natalia , Montone Kathleen T. , Fisher Aron B. , Rajapakse Chamith S. , Bermudez Christian , Chatterjee Shampa 
Published: May 2024

Introduction
Recent research suggests that endothelial activation plays a role in coronavirus disease 2019 (COVID-19) pathogenesis by promoting a pro-inflammatory state. However, the mechanism by which the endothelium is activated in COVID-19 remains unclear.

Objective
To investigate the mechanism by which COVID-19 activates the pulmonary endothelium and drives pro-inflammatory phenotypes.

Hypothesis
The “inflammatory load or burden” (cytokine storm) of the systemic circulation activates endothelial NADPH oxidase 2 (NOX2) which leads to the production of reactive oxygen species (ROS) by the pulmonary endothelium. Endothelial ROS subsequently activates pro-inflammatory pathways.

Methods
The inflammatory burden of COVID-19 on the endothelial network, was recreated in vitro, by exposing human pulmonary microvascular endothelial cells (HPMVEC) to media supplemented with serum from COVID-19 affected individuals (sera were acquired from patients with COVID-19 infection that eventually died. Sera was isolated from blood collected at admission to the Intensive Care Unit of the Hospital of the University of Pennsylvania). Endothelial activation, inflammation and cell death were assessed in HPMVEC treated with serum either from patients with COVID-19 or from healthy individuals. Activation was monitored by measuring NOX2 activation (Rac1 translocation) and ROS production; inflammation (or appearance of a pro-inflammatory phenotype) was monitored by measuring the induction of moieties such as intercellular adhesion molecule (ICAM-1), P-selectin and the NLRP3 inflammasome; cell death was measured via SYTOX™ Green assays.

Results
Endothelial activation (i.e., NOX2 activation and subsequent ROS production) and cell death were significantly higher in the COVID-19 model than in healthy samples. When HPMVEC were pre-treated with the novel peptide PIP-2, which blocks NOX2 activation (via inhibition of Ca2+-independent phospholipase A2, aiPLA2), significant abrogation of ROS was observed. Endothelial inflammation and cell death were also significantly blunted.

Conclusions
The endothelium is activated during COVID-19 via cytokine storm-driven NOX2-ROS activation, which causes a pro-inflammatory phenotype. The concept of endothelial NOX2-ROS production as a unifying pathophysiological axis in COVID-19 raises the possibility of using PIP-2 to maintain vascular health.
The usage of a modified straight-leg raise neurodynamic test and hamstring flexibility for diagnosis of non-specific low back pain: A cross-sectional study
Authors: Hermosura Joan , Lohman Everett , Bartnik-Olson Brenda , Venezia Jonathan , Daher Noha 
Published: May 2024

Objectives
The main purpose of this research study was to compare mean modified straight-leg raise test (mSLR) and hamstring muscle length (HL) between chronic non-specific low back pain (LBP) and healthy subjects to understand the possibility of neuropathic causes in LBP population as it may impact the diagnosis and treatment of LBP. Another purpose was to compare mean mSLR between those with lumbar nerve root impingement and those without as determine by magnetic resonance imaging (MRI).

Methods
The design of the study is cross sectional and included 32 subjects with ages ranging from 18–50 years old. Clinical exam objective measures were collected such as patient questionnaires, somatosensory tests, HL range of motion, and a mSLR test, and were compared to the findings from a structural lumbar spine MRI.

Results
There were no significant differences in mean HL angulation and mSLR angulation between LBP and healthy subjects (p>0.05). There was no significant difference in mean HL by impingement by versus no impingement (38.3±15.6 versus 44.8±9.4, p = 0.08, Cohen’s d = 0.50). On the other hand, there was a significant difference in mean mSLR angulation by impingement (57.6.3±8.7 versus 63.8±11.6, p = 0.05, Cohen’s d = 0.60).

Conclusions
The mSLR test was found to be associated with lumbar nerve root compression, regardless of the existence of radiating leg symptoms, and showed no association solely with the report of LBP. The findings highlight the diagnostic dilemma facing clinicians in patients with chronic nonspecific LBP with uncorrelated neuroanatomical image findings. Clinically, it may be necessary to reevaluate the common practice of exclusively using the mSLR test for patients with leg symptoms. This study may impact the way chronic LBP and neuropathic symptoms are diagnosed, potentially improving treatment methods, reducing persistent symptoms, and ultimately improving disabling effects.
Systematic review of contemporary interventions for improving discharge support and transitions of care from the patient experience perspective
Authors: Jesus Tiago S. , Stern Brocha Z. , Lee Dongwook , Zhang Manrui , Struhar Jan , Heinemann Allen W. , Jordan Neil , Deutsch Anne 
Published: May 2024

AimTo synthesize the impact of improvement interventions related to care coordination, discharge support and care transitions on patient experience measures.MethodSystematic review. Searches were completed in six scientific databases, five specialty journals, and through snowballing. Eligibility included studies published in English (2015–2023) focused on improving care coordination, discharge support, or transitional care assessed by standardized patient experience measures as a primary outcome. Two independent reviewers made eligibility decisions and performed quality appraisals.ResultsOf 1240 papers initially screened, 16 were included. Seven studies focused on care coordination activities, including three randomized controlled trials [RCTs]. These studies used enhanced supports such as improvement coaching or tailoring for vulnerable populations within Patient-Centered Medical Homes or other primary care sites. Intervention effectiveness was mixed or neutral relative to standard or models of care or simpler supports (e.g., improvement tool). Eight studies, including three RCTs, focused on enhanced discharge support, including patient education (e.g.,teach back) and telephone follow-up; mixed or neutral results on the patient experience were also found and with more substantive risks of bias. One pragmatic trial on a transitional care intervention, using a navigator support, found significant changes only for the subset of uninsured patients and in one patient experience outcome, and had challenges with implementation fidelity.ConclusionEnhanced supports for improving care coordination, discharge education, and post-discharge follow-up had mixed or neutral effectiveness for improving the patient experience with care, compared to standard care or simpler improvement approaches. There is a need to advance the body of evidence on how to improve the patient experience with discharge support and transitional approaches.
Impact of institutional support and green knowledge transfer on university students’ absorptive capacity and green entrepreneurial behavior: The moderating role of environmental responsibility
Authors: Yang Yejun 
Published: May 2024

Aim/objective
Given an escalated interest in fostering environmental protection, scholars have associated green entrepreneurial behavior as a stimulating factor and the cornerstone of green entrepreneurial performance. Nevertheless, the underlying mechanism that nurtures university students’ green entrepreneurial behavior is yet to be explored in the extant literature. Our study proposes the antecedent effects of institutional support and green knowledge transfer to enhance university students’ green entrepreneurial behavior. Moreover, we also expand the boundary conditions of these relationships and suggest the mediating effect of university students’ absorptive capacity and the moderating effect of environmental responsibility.

Methodology
The study samples university graduates in Chinese universities (N = 434) by adopting a lagged research design spanning over three months. We assessed the proposed model through the multivariate analytical technique.

Findings
The findings indicate that institutional support and green knowledge transfer significantly elevate university students’ green entrepreneurial behavior. Further, these relationships are intervened considerably through absorptive capacity’s mediating effect and environmental responsibility’s moderating effect.

Implications
By investigating the crucial roles of institutional support and green knowledge transfer in culminating university students’ green entrepreneurial behavior, our study extends the boundary conditions of these relationships and investigates the hitherto unexplored moderated mediation model.