bluuebunny/crossref_metadata_2025_split huggingface dataset:
Intracranial stenting as monotherapy in subarachnoid hemorrhage and sickle cell disease
Authors: Ediriwickrema Asiri , Williamson Theresa , Hebert Ryan , Matouk Charles , Johnson Michele H , Bulsara Ketan R 
Published: January 2012

IntroductionAlthough there have been a few reports of coiling intracranial aneurysms in patients with sickle cell disease (SCD), there are no reports of intracranial stent placement in this patient population. A patient in whom stent placement was utilized as monotherapy to treat a blister-like aneurysm is described and the implications of SCD and endovascular treatment are discussed.Case reportA 37-year-old man with SCD presented with diffuse subarachnoid hemorrhage. Angiography confirmed a 2 mm irregular aneurysm on the posterior cerebral artery which was treated with an oversized Neuroform 3 stent that was placed across the aneurysm neck by the senior author (KRB). Follow-up CT angiography showed no residual aneurysmal filling. The patient was discharged home in a stable condition, and he continues to do well 4 weeks following the procedure with no recurrence of the aneurysm.DiscussionThis report reviews hypercoagulability in SCD and the treatment options for intracranial aneurysms in patients with SCD. Additionally, the reported case suggests that intracranial stent placement may be a viable option for treating complex intracranial aneurysms in SCD patients.
Optimizing index scans on flash memory SSDs
Authors: Lee Eun-Mi , Lee Sang-Won , Park Sangwon 
Published: January 2012

Unlike harddisks, flash memory SSDs have very fast latency in random reads and thus the relative bandwidth gap between sequential and random read is quite small, though not negligible. For this reason, it has been believed that index scan would become more attractive access method in flash memory storage devices. In reality, however, the existing index scan can outperform the full table scan only in very selective predicates.
In this paper, we investigate how to optimize the index scan on flash memory SSDs. First, we empirically show that the index scan underperforms the full table scan even when the selectivity of selection predicate is less than 5% and explain its reason. Second, we revisit the idea of sorted index scan and demonstrate that it can outperform the full table scan even when the selectivity is larger than 30%. However, one drawback of the sorted index scan is that it loses the sortedness of the retrieved records. Third, in order to efficiently resort the result from the sorted index scan, we propose a new external index-based sort algorithm, partitioned sort, which exploits the information of key value distribution in the index leaf nodes. It can sort data in one pass regardless of the available sort memory size.
SAP HANA database
Authors: Färber Franz , Cha Sang Kyun , Primsch Jürgen , Bornhövd Christof , Sigg Stefan , Lehner Wolfgang 
Published: January 2012

The SAP HANA database is positioned as the core of the SAP HANA Appliance to support complex business analytical processes in combination with transactionally consistent operational workloads. Within this paper, we outline the basic characteristics of the SAP HANA database, emphasizing the distinctive features that differentiate the SAP HANA database from other classical relational database management systems. On the technical side, the SAP HANA database consists of multiple data processing engines with a distributed query processing environment to provide the full spectrum of data processing -- from classical relational data supporting both row- and column-oriented physical representations in a hybrid engine, to graph and text processing for semi- and unstructured data management within the same system.
From a more application-oriented perspective, we outline the specific support provided by the SAP HANA database of multiple domain-specific languages with a built-in set of natively implemented business functions. SQL -- as the lingua franca for relational database systems -- can no longer be considered to meet all requirements of modern applications, which demand the tight interaction with the data management layer. Therefore, the SAP HANA database permits the exchange of application semantics with the underlying data management platform that can be exploited to increase query expressiveness and to reduce the number of individual application-to-database round trips.
Quantifying the channel quality for interference-aware wireless sensor networks
Authors: Noda Claro , Prabh Shashi , Alves Mário , Boano Carlo Alberto , Voigt Thiemo 
Published: January 2012

Reliability of communications is key to expand application domains for sensor networks. Since Wireless Sensor Networks (WSN) operate in the license-free Industrial Scientific and Medical (ISM) bands and hence share the spectrum with other wireless technologies, addressing interference is an important challenge. In order to minimize its effect, nodes can dynamically adapt radio resources provided information about current spectrum usage is available.
We present a new channel quality metric, based on availability of the channel over time, which meaningfully quantifies spectrum usage. We discuss the optimum scanning time for capturing the channel condition while maintaining energy-efficiency. Using data collected from a number of Wi-Fi networks operating in a library building, we show that our metric has strong correlation with the Packet Reception Rate (PRR). This suggests that quantifying interference in the channel can help in adapting resources for better reliability. We present a discussion of the usage of our metric for various resource allocation and adaptation strategies.
Factors influencing college students' confidence in using electronic books as learning tools
Authors: Booker Queen E. , Kitchens Fred L. 
Published: January 2012

An earlier version of this paper was presented at the 2011 IEEE International Symposium on Technology and Society (ISTAS) at Saint Xavier University in Chicago, Illinois (and printed in the 2011 ISTAS proceedings).This paper examines factors in college student confidence in using electronic books as learning tools between 2007 and 2009. The study was done in response to the growing concern over the cost of textbooks and the increase in the use of e-textbooks to counteract that cost. This study shows that despite a lack of a gap between comfort of use of computers, students whose parents income is above the national median income are more confident in learning from electronic books than students whose parents income is not. Not only is this gap existent but it widened between 2007 and 2009 despite the growing confidence in the use of electronic books by both groups. The results of this study suggests that this gap, and its concomitant widening, could be associated with exposure to computer classes in high school and the choice of major.
Improving classroom visual accessibility with cooperative smartphone recordings
Authors: Kushalnagar Raja S. , Trager Brian P. 
Published: January 2012

An earlier version of this paper was presented at the 2011 IEEE International Symposium on Technology and Society (ISTAS) at Saint Xavier University in Chicago, Illinois (and printed in the 2011 ISTAS proceedings).
We propose a cooperative approach by students in recording lecture activities such that the classroom becomes more visually accessible for everyone, especially for deaf, hard of hearing and low-vision students. Students utilize their personal camera-equipped smart phones to capture and share their views of a visually inaccessible classroom to students' devices. We show this approach virtually retrofits a classroom to make it a more visually accessible learning environment. This approach can be used in meetings to get and share optimal views of the meeting for all participants.
Getting started with GENI
Authors: Duerig Jonathon , Ricci Robert , Stoller Leigh , Strum Matt , Wong Gary , Carpenter Charles , Fei Zongming , Griffioen James , Nasir Hussamuddin , Reed Jeremy , Wu Xiongqi 
Published: January 2012

GENI, the Global Environment for Network Innovations, is a National Science Foundation project to create a "virtual laboratory at the frontiers of network science and engineering for exploring future internets at scale." It provides researchers, educators, and students with resources that they can use to build their own networks that span the country and---through federation---the world. GENI enables experimenters to try out bold new network architectures and designs for networked systems, and to deploy and evaluate these systems on a diverse set of resources over a large footprint.
This tutorial is a starting point for running experiments on GENI. It provides an overview of GENI and covers the process of creating a network and running a simple experiment using two tools: the Flack GUI and the INSTOOLS instrumentation service.
Metastasis-Associated Protein 1/Nucleosome Remodeling and Histone Deacetylase Complex in Cancer
Authors: Li Da-Qiang , Pakala Suresh B. , Nair Sujit S. , Eswaran Jeyanthy , Kumar Rakesh 
Published: January 2012

AbstractCancer cells frequently exhibit deregulation of coregulatory molecules to drive the process of growth and metastasis. One such group of ubiquitously expressed coregulators is the metastasis-associated protein (MTA) family, a critical component of the nucleosome remodeling and histone deacetylase (NuRD) complex. MTA1 occupies a special place in cancer biology because of its dual corepressor or coactivator nature and widespread overexpression in human cancers. Here, we highlight recent advances in our understanding of the vital roles of MTA1 on transformation, epithelial–mesenchymal transition, and the functions of key cancer-relevant molecules such as a nexus of multiple oncogenes and tumor suppressors. In addition to its paramount role in oncogenesis, we reveal several new physiologic functions of MTA1 related to DNA damage, inflammatory responses, and infection, in which MTA1 functions as a permissive “gate keeper” for cancer-causing parasites. Further, these discoveries unraveled the versatile multidimensional modes of action of MTA1, which are independent of the NuRD complex and/or transcription. Given the emerging roles of MTA1 in DNA repair, inflammation, and parasitism, we discuss the possibility of MTA1-targeted therapy for use not only in combating cancer but also in other inflammation and pathogen-driven pathologic conditions. Cancer Res; 72(2); 387–94. ©2012 AACR.
Association of HER2/ErbB2 Expression and Gene Amplification with Pathologic Features and Prognosis in Esophageal Adenocarcinomas
Authors: Yoon Harry H. , Shi Qian , Sukov William R. , Wiktor Anne E. , Khan Maliha , Sattler Christopher A. , Grothey Axel , Wu Tsung-Teh , Diasio Robert B. , Jenkins Robert B. , Sinicrope Frank A. 
Published: January 2012

Abstract
Purpose: We examined the frequency, tumor characteristics, and prognostic impact of HER2 protein expression and gene amplification in patients with curatively resected esophageal adenocarcinoma (EAC).
Experimental Design: HER2 expression was analyzed by immunohistochemistry (IHC) in surgical EAC specimens (n = 713). Gene amplification was examined by FISH in a large subset (n = 344). Most tumors were T3–4 (66%) or node positive (72%); 95% were located in the esophagus or gastroesophageal junction. No patient received neoadjuvant therapy. Cox models were used.
Results: Overall, 17% of EACs were HER2 positive (i.e., IHC3+ or IHC2+ with amplification), with strong agreement between HER2 amplification (HER2/CEP17 ratio ≥2) and expression (κ = 0.83). HER2 positivity was significantly associated with lower tumor grade, less invasiveness, fewer malignant nodes, and the presence of adjacent Barrett's esophagus (BE). EACs with BE had higher odds of HER2 positivity than EACs without BE, independent of pathologic features [OR = 1.8 (95% CI: 1.1–2.8), P = 0.014]. Among all cases, HER2 positivity was significantly associated with disease-specific survival (DSS) in a manner that differed by the presence or absence of BE (Pinteraction = 0.0047). In EACs with BE, HER2 positivity was significantly associated with improved DSS [HR = 0.54 (95% CI: 0.35–0.84), P = 0.0065] and overall survival (P = 0.0022) independent of pathologic features, but was not prognostic among EACs without BE.
Conclusions: HER2 positivity was shown in 17% of resected EACs and associated with reduced tumor aggressiveness. EACs with BE had nearly twice the odds of being HER2 positive and, within this subgroup, HER2 positivity was independently associated with improved survival. Clin Cancer Res; 18(2); 546–54. ©2012 AACR.
Early outcomes of carotid artery stenting
Authors: Akar Bayram N , Bozkurt E , Ayhan H , Gürkaş E , Orhan G , Ak F , Bilen E , Sarı C , Akçay M , Durmaz T , Keleş T 
Published: January 2012

Background and aim: Ischemic cerebrovascular events are the most common reason for patients to be bedridden and the third most common reason for death. Many studies in recent years have demonstrated that carotid artery stenting (CAS) may be an alternative to carotid endarterectomy (CEA). In this study, we aimed to report early outcomes of patients who were treated with CAS in our clinic and discuss practicability, advantages and safety of CAS. Methods and Findings: Eighty patients who underwent CAS between December 2009 and May 2011 were eligible. The mean age was 65 years (range, 49 - 89 years). Of the study group, 73.75% were males and 26.25% were female. The percentage of asymptomatic patients was 11.7%, and the remaining patients were symptomatic. A distal embolic protection device (Angioguard®) was used in 22% of the patients whereas, in the other patients (78%), a proximal blockage system (Mo.MA®) was used. Self-expandable hybrid stents were implanted in all patients and post-dilatation was performed after implantation. None of the patients suffered from stroke, myocardial infarction or death due to CAS during their hospital stay. The mean follow-up period was 10 months (range 2 - 18 months) after discharge. None of the patients had died or had a stroke, a transient ischemic attack (TIA), or a myocardial infarction during the follow-up period. Re-stenosis was not observed in the follow-up carotid Doppler ultrasonography; flow rates were within normal limits. Conclusion: No major complication was observed during the early follow-up period in patients who underwent CAS in our clinic. Only 2 (2.5%) patients showed transient numbness and weakness and these did not lead to morbidity. In the management guide of extracranial carotid and vertebral artery diseases, CAS, in the light of recent studies, is recommended as an alternative to CEA in recommendations for revascularization. One of the important issues emphasized in this guide is the experience of centers. Very low complication rates after CAS suggested that, with suitable patient selection and an experienced team, similar results may be obtained.
RETRACTED: Supply Chain Management: Value Configuration Analysis Approach
Authors: Baig Viqar Ali , Akhtar Javaid 
Published: January 2012

Retraction Notice: Viqar Ali Baig and Javaid Akhtar (2011). ‘Supply Chain Management: Value Configuration Analysis Approach: A Case Study’, Vision: The Journal of Business Perspective, 15(3), 251–266. Doi: 10.1177/097226291101500305 has been retracted because this article contains unattributed overlap with material from the following article: Lars Huemer (2006). ‘Supply Management: Value creation, coordination and positioning in supply relationships’, Long Range Planning, 39(2), 133–153. The editor of Vision: The Journal of Business Perspective and the Publisher extend their sincere apology to Dr Lars Huemer. Value creation in the supply chain literature normally builds on the value chain model (VCM). This results in a focus on succedent interdependencies, a focus on coordination by planning and a restricted view of likely positioning options. This article contributes an original approach to the supply chain management (SCM) debate, based on value configuration analysis (VCA). VCA recognizes the value chain logic (VCL), but finds it restraining in particular business systems, and also includes recognition of the value network model (VNM) as representing the layered supply chain relationships (SCRs) classically related with a mediating presence. In general, this article contributes in two ways: by enlightening some of the complexities to be addressed in managing SCRs and by looking at how SCRs function despite this complexity. In particular, it presents an alternative view of how value creation happens between, as well as within, firms in SCRs. It discloses how more complex sets of supply chain interdependencies exist in SCRs than in simple chains, and that these necessitate managing by a variety of coordination machineries to achieve efficient working. Finally, it suggests a novel way to define a firm’s supply chain position beyond that covered by the conventional upstream/downstream terms. These arguments are illustrated with the help of a case study and are related to previous work on supply chains and networks.
Effect of the tin- versus air-side plate-glass orientation on the impact response and penetration resistance of a laminated transparent armour structure
Authors: Grujicic M , Bell W C , Pandurangan B , Cheeseman B A , Patel P , Dehmer P G 
Published: January 2012

Our recently developed continuum-level, physically based, high strain-rate, large-strain, high-pressure mechanical material model for soda-lime glass has been enhanced to include differences in the flaw-size population between the so-called air-side and the so called tin-side of float-glass plates, and adapted for use in the case of borosilicate glass. The model was structured in such a way that it is suitable for direct incorporation, as a material user-subroutine, into standard commercial transient non-linear dynamics finite-element-based software packages. The model was parameterized using various open-literature sources. The experimental portion of the work, which consisted of 28 projectile impacts onto glass/polyurethane/polycarbonate-based test laminates, was intended to allow for quantification of the effect of air- versus tin-side borofloat strike surface when incorporated into a multi-layer, multi-functional test laminate. Experimental findings indicated the lack of a significant difference in the impact resistance of air- versus tin-side test laminate strike surfaces. Subsequent to these findings, computational simulations were carried out in order to establish if the proposed borofloat material model could capture the prominent experimentally observed damage modes and the measured V50, reconfirming the experimental findings. In general, a good agreement was found between the computational and the experimental results.
Association between angiotensin-converting enzyme gene polymorphism and diabetic retinopathy in the Chinese population
Authors: Lu Yan , Ge Yirui , Hu Qinrui , Shi Yuhua , Xue Chunyan , Shi Yao , Chen Suihua , Huang Zhenping 
Published: January 2012

Objective: The angiotensin-converting enzyme ( ACE) gene has been implicated in the development of diabetic retinopathy (DR). However, the results have been conflicting. In this study, we performed a meta-analysis to assess the association of insertion/deletion (I/D) polymorphism in the ACE gene with DR in the Chinese population. Methods: Published literature from PubMed, CNKI, CBM and Wanfang Data were retrieved. Pooled odds ratio (OR) with 95% confidence interval (CI) was calculated using fixed- or random-effects model. Results: Seventeen studies (1039 cases and 1185 controls) for I/D polymorphism in the ACE gene were identified. The results suggested that I/D polymorphism D allele might increase the risk of DR (DD vs. II: OR = 1.73, 95% CI 1.19–2.51; DD+ID vs. II: OR = 1.41, 95% CI 1.16–1.72; DD vs. ID+II: OR = 1.55, 95% CI 1.13–2.12). Subgroup analyses based on the type of DR showed that the effect size was statistically significant for proliferative DR (PDR) (DD vs. II: OR = 2.67, 95% CI 1.53–4.64; DD+ID vs. II: OR = 1.86, 95% CI 1.18–2.93; DD vs. ID+II: OR = 2.22, 95% CI 1.38–3.55), but not for background DR (BDR) (DD vs. II: OR = 1.38, 95% CI 0.85–2.25; DD+ID vs. II: OR = 1.40, 95% CI 0.98–2.02; DD vs. ID+II: OR = 1.15, 95% CI 0.74–1.79). Conclusion: The results indicated that I/D polymorphism in the ACE gene was associated with PDR, but not with BDR in the Chinese population.
Effects of tiotropium and formoterol on quiet breathing pattern assessed by optoelectronic plethysmography in COPD patients: a pilot study
Authors: Dal Negro Roberto Walter , Turati Claudio , Micheletto Claudio , Menegoni Francesco 
Published: January 2012

Introduction: Chronic obstructive pulmonary disease (COPD) is a disease characterized by an airflow limitation that is not fully reversible. β2-agonists and anticholinergics represent the most effective therapeutic options. Optoelectronic plethysmography (OEP) is a novel technology, which provides noninvasive steady-state measurements of chest wall kinematics, together with the assessment of the relative contribution of all different thoracic and abdominal compartments to tidal volume. Objectives: The aim of this pilot study was to investigate the changes in quiet breathing due to different long-acting bronchodilators (namely, formoterol and tiotropium) administered to COPD patients of different severity. Methods: Eight moderate-to-severe COPD patients were studied according to a randomized crossover design. All subjects received both the long-acting bronchodilators: formoterol (long-acting β2-agonist, 24 µg) and tiotropium (long-acting anticholinergic bronchodilator, 18 µg). The effect of bronchodilators on quiet breathing was evaluated by means of OEP at base conditions, and 2 and 7 hours after inhalation. Results: Both bronchodilators caused changes in the quiet breathing pattern in COPD patients that had previously reported only negligible changes in FEV1 (ΔFEV1 = 2.6% after salbutamol). The main changes were observed in increased ventilation per minute, inspiratory and expiratory flow, and decreased breath-by-breath variability. Formoterol induced its main effects during the first 2 hours after inhalation, while tiotropium caused improvements between 2 and 7 hours. Conclusion: Even though a greater cohort of COPD patients is needed in order to confirm the present results, this pilot study reports a novel piece of evidence concerning the effects of bronchodilators on quiet breathing pattern in severe and very severe COPD patients.