bluuebunny/crossref_metadata_2025_split huggingface dataset:
P01-13 - The Bipolar Patients Observance and Participation in Cognitive Behavioral Therapy Groups Tend to be Improved Through Mindfulness Meditation
Authors: Bonvalot T. , Placines B. , Bouché C. , Le Moigne L. , Boldi I. , Millet B. , Thym Breizh 
Published: June 2010

Cognitive-behavioral therapy (CBT) is being used, individually or in group format, to improve outcome and prevent relapse of patients with bipolar disorder (BD). CBT shows nevertheless limitations with regard, mainly, to patients having undergone a great number of mood episodes. In one published study, patients with more than 12 mood episodes typically did not respond favorably to the procedures, and for some, their clinical condition worsened.Understandably, a high dropout rate has also been observed in other studies.ObjectivesTo overcome these limitations, we combined CBT with mindfulness meditation.MethodsIn our mood clinic, two different programs have been proposed to this day:- A short mindfulness-based, stress-reduction program (8 weekly sessions), well-adapted to bipolar patients :- A program of 20 weekly relapse prevention sessions, including 5 consecutive constructive therapy stages (T. Bonvalot et al.: Constructive Psychotherapy of Bipolar Disorder: A New Approach (abstract) - Bipolar Disorders, special issue, June 2009).Bipolar patients with more extensive clinical conditions are successively invited to participate to both programs.ResultsEvery session has been facilitated by a mindful attitude progressively developed by the patients all along the programs.We observed that mindfulness meditation, along with CBT, presents most often a high acceptation level on the part of most bipolar patients, and a capacity to restore self-image, self-confidence and hopefulness.ConclusionThe patients’ involvement in the treatment programs have developed on a regular basis, and consequently a low dropout rate has been observed.These observations are to be now formally evaluated.
P01-14 - Efficacy of a Newly Developed Method of Receptive Music Therapy for the Treatment of Depression
Authors: Brandes V. , Terris D.D. , Fischer C. , Loerbroks A. , Jarczok M.N. , Ottowitz G. , Titscher G. , Fischer J.E. , Thayer J.F. 
Published: June 2010

ObjectivesCurrent treatment approaches for depression center on various forms of psychosocial therapy and the use of antidepressant drugs. The response rates for both of these approaches are similar, with mostly reduction, but not complete remission, of symptoms. Poor adherence to recommended treatment is an issue complicating the management of depression and prevention of recurrent episodes. This study evaluated the efficacy of a novel form of receptive music therapy which can be easily adminstered to out patients.MethodsEnrolled subjects (n=203, average age 49.6 ± 13.1 years, 28.1% male) were randomized into four arms: Music Therapy 1 (MT1), Music Therapy 2 (MT2), Placebo (nature sounds) and waiting-list Control. Subjects listened for 30 minutes, twice daily. Multivariate linear regression models assessed depressive symptom changes over five weeks, based on a composite scale (COMP) and the Hamilton Rating Scale for Depression (HAM-D), Beck Depression Inventory (BDI) and Hospital Anxiety and Depression Scale (HADS-D) alone.ResultsOn average, a significant, positive change in COMP was observed for MT1 (β=1.44, p=0.030), but not for MT2 (β=1.14, p=0.059) or Placebo (β=0.57, p=0.397). After 15 weeks, study participation was associated with a mean HAM-D score reduction of 60% for 89,1% of the compliant probands.ConclusionsNewly composed receptive music therapy, as explored in this study, is associated with reduced depressive symptoms and high treatment compliance, and may therefore potentially represent an effective depression treatment alternative or adjunctive therapy to pharmacological and psychosocial approaches.
P01-19 - Patients with Depression in Primary Care: Approach Through Psychoeducational Group Intervention
Authors: Casañas R. , del Val Garcia J.L. , Raya A. , Romero T. ,   The Research Group on Depression (Psychoeducational Group Program)
Published: June 2010

ObjectivesTo compare the effectiveness of a psychoeducational group program and conventional treatment versus individual conventional care in patients with a mild/moderate depression disorder in urban primary healthcare centers (PHCC).Methods:Designrandomized controlled trial of two groups.Samplepatients aged 20 years attended in 13 PHCC, identified by general practitioners and nurses with diagnosis of mid/moderate depression disorder (BDI scale) between December 2008 and April 2009.The intervention group received a psycoeducational group program (12 weeks, two nurses). The program provided health education about the illness, pharmacological treatment, diet, physical exercise, problem solving, and cognitive-behavioral therapy.The control group received conventional care.The evolution of patients is monitoring up to 1 year after the inclusion by an individual interview (baseline and 3, 6, 9 months).The battery of assessment included: Sociodemographic, BDI and EuroQol-5D questionnaires.Results241 patients (126 intervention Group (IG); 115 control Group (CG)), 217 women (53% IG and 47%CG) with a mean age of 54, 11 (SD=12,656). 92% Spanish. 45% married. Academic level: 76, 5 % study and 13,5% non-study.The mean BDI in the baseline GI 21, 66 (SD=6,87) and CG 19.62(SD=6.85), follow up 3 months, GI 13,91(SD=8.22) and CG 17,07(SD=7,930). The mean of EuroQoL in the baseline IG 48, 29 (SD= 17,77) and CG 53,0 (SD= 19,06), follow up 3m, GI 56,57(SD=22,12) and CG 45,28(SD=23,74).ConclusionsThe two groups are comparable for all variables analyzed. There is an improvement in the IG versus CG on depressive symptoms and quality of life.
P01-23 - Compliance with Treatment - a Prerequisite for Diagnosing and Treatment Efficacy
Authors: Dadic Hero E. , Ruzic K. , Medved P. , MacDonald E. , Tatalovic Vorkapic S. 
Published: June 2010

AimLack of patient compliance in a general psychiatric ambulatory causes delays in diagnosing as well as in patient treatment efficacy.Methoda 30 year old patient underwent a psychiatric treatment which lasted two yaers. He was treated with a combination of psychopharmacs and psychotheraphy.ResultsThe patient contacted a psychiatrist for the first time exhibiting the following symptoms: loss of will and interests, weight gain, lowered general mood, avoidance of social contacts. A depressive episode was diagnosed and and antidepressive was introduced to his therapy (fluvoxamine). He did not comply to the therapy assigned nor he attended his scheduled examination.His medicamentous therapy was intensified (fluoxamine, alprazolam, promazine). After six months, the patient returned in company with his family, and his non-compliance with the therapy was revealed.After a sucessfful therapy an improvement in his mental state was noticed. During the last year, he was regular at his examinations and medication, with psychotherapy once a week.ConclusionPatient compliance is a prerequisite for diagnosing and a successful treatment. Combined treatment methods (psychopharmacotherapy, psychotherapy) with an adherend patient guarantee a good remission.
P01-30 - Folate Deficiency in Outpatients with a Diagnosis of Unipolar Depression in Mental Health Center
Authors: Doll A. , Perez A. , Pina L. , Mena A. , Martin M. , Portoles J.J. 
Published: June 2010

Folate deficiency have been linked to depression, anxiety, persistent depressive symptoms, and poor antidepressant response.ObjectivesDetermine levels of folic acid and vitamin B12 in a sample of depressed patients in the first visit to mental health center.AimsDemonstrate a high prevalence of folate and vitamin B12 deficiency in this group of patients and the relation with the depression and treatment resistant.MethodThe sample was all the patients with a diagnosis of unipolar depression, who were derivated by general practitioner (GP) between January and June 2009 to Vallecas Villa Mental Health Center in Madrid. The sample was 82 patients, they were between 20 and 86 years old. In 62 cases the GP derivated the patients because resistant to treatment, and in 20 cases were naive-treatment. In the first visit folate serum and vitamin B12 were measured.Results69 patients present low levels of folate (84,14%), and 4 low levels of vitamin B12 (4,87%). The mean of folate was 2,2 ng/ml in low-serum folate sample and the mean of vitamin B12 was 93 pg/ml in low vitamin B2 sample. 90,80% (56) of the resistant-treatment group presents low folate serum, in the naive sample was 65% (13).ConclusionsIn our sample depression is associated to a very high prevalence of folate deficiency. The highest prevalence appeared in the resistant-treatment group, so it could be a factor that influence in the persistent depressive symptoms, and poor antidepressant response.
P01-33 - System of Screening for the Depressive Pattern
Authors: Enatescu V. , Enatescu V.R. 
Published: June 2010

The models of non-verbal behavior and communication constitute the basis of the clinical experience that determinate the presumptive diagnoses or initial diagnoses.In depression, according to statistics, the majority of cases aren’t detected being treated by other medicine specialties or remaining without being treated.We propose a study that would develop a system of screening which would detect the cases suspected of depression. This is based on the gait pressure analyses, model AGILE, the analyses of the physical specter of speech, the automatic analyses of gesture. All these three investigations can be realized in a very short period of time, of a few minutes for every case.The pressure of the gat analyses took only tens of seconds. The suspected cases go forward to gesture and speech analyses, which took three minutes.The determination of the diagnostic is made after the psychiatric clinical examination, after the known criteria.At this system can be add the recognizing of depressive facies, after methods known in the natural intelligence.Between the non-verbal communication channels: gait, voice, gesture, mimic, exists a solidarity, which increases the chance of recognizing the depression, the solidarity loosing in schizophrenia and this could be recognized as an element of semiology in the differential diagnostic.
P01-34 - The Influence of Clinical and non Clinical Factors on Academic Skills in a Romanian Sample with Recurrent Depression
Authors: Enatescu V.R. , Enatescu I. 
Published: June 2010

IntroductionRecurrent depression could be considered as a stumbling block for the individuals during their active period of life. Beside the global functionality, recurrent depression could affect negatively academic skills of depressed subjects that will result in considerable higher indirect costs of the disorder. Our main objective was to reveal the clinical and non clinical factors correlated with academic impairment in subjects with recurrent depression.Material and methodsWe performed a longitudinal retrospective study on 248 patients admitted in our Clinic for Recurrent depressive disorder during 2001 - 2005. Two control samples were done, one with Bipolar affective disorder (N=44) and other with Persistent delusional disorder (N=59).ResultsFrom 90 depressed subjects who were employed at the onset of psychiatric disorder, 56 (62.2%) became retired and another 6 (6.6%) became unemployed. Despite the treatability of recurrent depression the negative outcome on academic skills was similar to that occurring in both control groups that traditionally are considered as being more disabling. The clinical factors that concurred to the worsening of academic status were the more advancing age at the onset and actual moment of recurrent depression (p=0.006 and p=0.012 respectively), along with longer total duration of recurrent depression (p< 0.001), the absolute total number of depressive episodes and psychiatric hospitalizations (p=0.001).Conclusions and discussionsRecurrent depression has a significant negative outcome on academic skills. The disabling character of recurrent depression could be caused by its high chronicity along with high recurrent pattern of clinical evolution.
P01-44 - Euthymic Bipolar Patients’ Deficits in in Social Cognition Tasks
Authors: Hajnal A. , Varga E. , Herold R. , Tényi T. , Fekete S. , Simon M. 
Published: June 2010

ObjectivesTheory of mind (ToM) has been proved to play a crucial role in social cognition and functioning. In our study, higher order mentalization performance of euthymic bipolar I patients were compared with that of healthy controls. The impact of demographic data, course of the disorder and patients’ current functioning were also considered while interpreting mentalization data.MethodsThe mentalizing performance (computerized faux pas task and false irony task), neurocognitive functioning, and IQ of twenty-three euthymic bipolar I patients and 31 matched (IQ, age) healthy controls were examined. In the patients group, the age at onset, the occurrence of psychotic symptoms, age, education, current employment status, and global functioning were also taken into account.ResultsBipolar patients scored significantly lower in false irony tasks than healthy controls (p< 0,02). The deficit in irony tasks positively correlated with the number of episodes. Among the examined variables, the performance in the faux pas task predicted most closely the functional outcome in bipolar I disorder. No correlation was found between the ToM and irony deficits and the occurrence of psychotic symptoms, the length of the bipolar disorder or neurocognitive functioning.ConclusionOur results showed impaired performance in faux pas and irony tasks, which correlates with the number of previous episodes. Additionally, the impairment of ToM functions predicts a worse functional outcome.
P01-46 - Depression in Diabetic Women and Identification by Primary Care Physicians in UAE
Authors: Hawamdeh S. 
Published: June 2010

ObjectiveThe aim was to:1)identify the prevalence of depression in diabetic women presenting in a primary care clinic;2)determine if the primary care physician detected depression in these patients; and3)determine if a relationship existed between depression and glycemic control (Hgb A1C) in these patients.MethodProspective, convenience sample. All women with a diagnosis of Type I or II Diabetes Mellitus were included. Participant's charts were audited for documentation of Hgb A1C levels, and the diagnosis of depression. Patients were asked to complete Beck Depression Inventory (BDI II) scale. Participants who score 16 or higher on the BDI were considered depressed. Participants' scores on BDI II and their Hgb A1C levels were compared with demographic data, and chart verification of depression. Statistical analyses was accomplished using Chi-Square for categorical variables and student's t-test for independent variables all analyses was run using SPSS v. 10Results61 patients participated. When prevalence of depression in diabetic participants was compared with BDI II scores, 47% (N=24) of participants were found to be depressed. Primary care physician recognized and documented depression in 4% (N=2) of the depressed participants. The mean Hgb A1C was higher for depressed participants (9.31%) when compared to non-depressed participants (8.03%), but was not statistically significant I II (p =.788).ConclusionsDepression was a major problem for patients with diabetes presenting to primary care clinic, and that diabetes was under diagnosed. Contrary to previous studies, patients in this study with diabetes and depression had similar glycemic control.
P01-48 - Haloperiol is a Better Choice than Risperidone for Patients with Schizopherenia with Positive Familial History
Authors: Kalbasi Anaraki P. 
Published: June 2010

IntroductionSchizophrenia is still one of the most mysterious and costliest mental disorders in terms of human suffering and societal expenditure that affects about 1.1 percent of the world population. But is there any difference for treating schizophrenia due to its cause? In this study we evaluate the therapeutic effect of haloperidol and risperidone in patients with positive familial history.Method and materialsWe had chosen 110 men with schizophrenia with positive familial history, who refer to psychology institute of Rasul Hospital in Tehran in 2000 to 2009. We divided these patients into two main groups by random, each group have 55 patients. For case group Haloperidol was used to control their symptoms and for the control group risperidone was used. During a period of one year we evaluate their response to the treatment in different groups.ResultsThe mean age of patients in case group was 34.8 and for control group it was 34.4. From the case group 45.2% show decrease in their symptoms and in control group just 36.6% so the therapeutic effect of haloperidol was significantly better than risperidon for patients who have positive familial history. In addition after 6 months of therapy just 12% of patient in case group have remission but is control group we faced 28.3%.DiscussionIt is better to use the first line anti psychotic, haloperidol, in patients with positive familial history. This help to more decrease in symptoms and also the less chance for remission.
P01-49 - The Study Protocol of the Norwegian Randomized Controlled Trial of Electroconvulsive Therapy in Treatment Resistant Depression in Bipolar Disorder
Authors: Kessler U. , Schøyen H. , Vaaler A. , Ødegaard K. , Bergsholm P. , Andreassen O.A. , Malt U. , Morken G. 
Published: June 2010

IntroductionThe treatment of depressive phases of bipolar disorder is challenging. Electroconvulsive therapy (ECT) is generally considered to be the most effective treatment even if there are no randomized controlled trials (RCT) of ECT in bipolar depression. The safety of ECT is well documented, but there are some controversies as to the cognitive side effects.ObjectivesTo compare the effects and side effects of ECT with pharmacological treatment in treatment resistant bipolar depression. Cognitive changes during the treatment will be measured, as well as quality of life.MethodA prospective, randomised controlled multi-centre trial. 6- week acute treatment trial with 7 clinical assessments. Follow up visit at 26 weeks or until remission (max 52 weeks). A neuropsychological test battery designed to be sensitive to changes in cognitive function will be used.SettingNine study centres across Norway, all acute psychiatric wardsSample132 patients aged 18 and over, who fulfil criteria for treatment resistant depression in bipolar disorder, MADRS score of at least 25 at baselineInterventionIntervention group: 3 sessions per week for up to 6 weeks, total up to 18 sessions. Control group: algorithm-based pharmacological treatment as usual.ResultsSix departments have included 43 patients since start in May 2008.ConclusionThis study is the first randomized controlled trial that aims to investigate whether ECT is better than pharmacological treatment as usual in treatment resistant bipolar depression. Possible long lasting cognitive side effects will be evaluated. The study is investigator initiated, without support from industry.
P01-51 - Depressed Mood in Divorced and Undivorced Women
Authors: Khanmohammadi Otaghsara A. , Yaghoubi Hasankola G. 
Published: June 2010

Objective & aimThe study aims to investigate depression in sample of women in divorced situation and comparison with normal ones (undivorced women).MethodMethod research is causative-comparative (Ex post facto). 30 divorced and 30 undivorced women age between 25-30 randomly were selected and Beck's depression questionnaire was administered on them. T independence test was used to analyze the data.ResultsFindings shows significant differences between tow groups. Divorced women have high scores in depression questionnaire. Also 70 percent of divorced women were in deep depression.ConclusionThe findings indicated rate of depression in divorced women range from moderate to deep with affective and emotional disturbances that shows psychiatric disorders in the women and is needed plans and programs to relieve their depression and back them to social life.
P01-52 - State-of-art Neuroimaging Technologies and Negotiation of the Pharmacological Resistance in Anxious-obsessive and Depressive Disorders
Authors: Korzenev A. , Shamrey V. , Abritalin E. , Tarumov D. , Lebedev A. , Belousova A. , Fokin V. , Sokolov A. 
Published: June 2010

IntroductionThe neuroleptics, which were invented in the middle of the last century, have changed psychiatry as the clinical discipline, and a problem of the pharmacological resistance insensibly has become the main problem. A radical way to overcome the resistance of the anxious and depressive disorders lies in the field of the modern neurosurgical techniques. However, the verification of the resistance still requires more developed approach.AimThe main aim of our study was to develop and test an integrated neuropsychiatric approach in order to objectify the resistance and the disease severity for the selection of patients for surgical treatment.Methods and participantsWe used different types of neuroimaging techniques for reviewing clinical and neurophysiological correlations: positron-emission tomography (PET), functional magnetic resonance imaging (fMRI), diffusion-tensor imaging (DTI) and its relations to the electroencephalography (EEG) data.We examined 110 patients with depressive and anxious-obsessive disorders. 40 of them were examined using fMRI, 35 using PET and 35 using DTI. The patients were divided into groups by the ICD-10 criteria. The average age of the group was 46.3 years, the number of males and females in groups was approximately equal.ResultsIt was revealed that the degree of resistance had a significant correlation with the number of functional and structural neuroimaging indicators.ConclusionsWe obtained data which objectifies the concept of resistance. We also represent our understanding of clinical and physiological approach to the selection of target structures for stereotaxic neurosurgical exposure (in particular for deep brain stimulation) in the complex treatment.
P01-53 - Local Adherence to National Guidelines in the Management of Bipolar Affective Disorders
Authors: Kumar A. , Rao K.P. 
Published: June 2010

IntroductionBipolar affective disorders contribute significant mortality and morbidity in the management of mental disorders in developed and developing countries. A recent review reported 12- month estimates of approximately 1% (range 0.5% - 1.1%). The current practice reveals large variations in the standards of care delivery with non existent protocols in third world countries. National Institute of Health and Clinical Excellence (NICE, United Kingdom) has developed guidelines that dictate the best practice in the management of Bipolar disorder in England and Wales.ObjectivesWe compared local adherence to and uptake of NICE guidelines for Bipolar affective disorders (supposedly the best practice).AimsTo feedback Managers and practicing psychiatrists in the local trust about the shortcomings in the best practice as per national guidelines.MethodsWe reviewed the clinical notes of nearly one-third of all the service users diagnosed with Bipolar Affective Disorder (ICD code F31) in a rural county in England.Results & conclusionsThe need to discuss pharmacological options with the patients to help make them an informed choice as well as offering psychological treatments and life style advice were the most deficient areas of practice. We plan to reaudit the practice to document changes in practice.