bluuebunny/crossref_metadata_2025_split huggingface dataset:
An Intraocular Lens Power Calculation Formula Based on Optical Coherence Tomography: A Pilot Study
Authors: Tang Maolong , Li Yan , Huang David 
Published: August 2010

Purpose:
To develop an intraocular lens (IOL) power calculation formula based on optical coherence tomography (OCT) that would not be biased by previous laser vision correction.

Methods:
Twenty-seven eyes of 27 cataract patients without prior laser vision correction who underwent phacoemulsification were included in the study. An optical coherence biometer (IOLMaster, Carl Zeiss Meditec) measured anterior corneal curvature and axial eye length. A high-speed (2000 Hz) anterior segment OCT prototype mapped corneal thickness and measured anterior chamber depth and crystalline lens thickness. Posterior corneal curvature was computed by combining IOLMaster keratometry with OCT corneal thickness mapping. A new IOL formula was developed based on these parameters. One month after phacoemulsification, the manifest refraction spherical equivalent (MRSE) was measured. The prediction error in postoperative MRSE of the OCT-based IOL formula was compared with that of three theoretic formulae: SRK/T, Hoffer Q, and Holladay II.

Results:
The mean prediction error in postoperative MRSE of the OCT-based formula was 0.04±0.44 diopters (D). The SRK/T was the best of the theoretic formulae, and its prediction error was −0.35±0.42 D. Twenty-one (78%) eyes were within 0.50 D using the OCT formula compared to 18 (67%) eyes using the SRK/T. No statistically significant differences were noted among the formulae.

Conclusions:
For cataract patients without prior laser vision correction, the OCT-based IOL formula was as accurate as the current theoretic formulae. This new formula is based on direct OCT assessment of the posterior curvature and avoids the calculation errors inherent in conventional IOL formulae.
Anterior Segment Optical Coherence Tomography Measurement of Flap Thickness After Myopic LASIK Using the Moria One Use-Plus Microkeratome
Authors: Chen Hui-Jin , Xia Ying-Jie , Zhong Yan-Ying , Song Xiao-Li , Chen Yue-Guo 
Published: August 2010

Purpose:To analyze the accuracy and consistency of corneal flap thickness created in myopic LASIK using the Moria One Use-Plus microkeratome compared with the Moria M2 Single Use 90-μm microkeratome.Methods:Bilateral LASIK was performed in 68 myopic patients. Flaps were created using the One Use-Plus microkeratome in 82 eyes (41 patients) and the M2 90-μm microkeratome in 54 eyes (27 patients). Flap complications and visual outcomes were evaluated. Horizontal “High Res. Corneal” scan pattern of anterior segment optical coherence tomography (AS-OCT) was applied to measure flap thickness at five locations (0, ±2, and ±3.5 mm from the corneal vertex) on the first postoperative day.Results:No significant differences were noted in flap complications and visual outcomes between groups. The central flap thickness was dramatically thinner in the One Use-Plus group (114.7±10.1μm and 109.4±11.0μm for right and left eyes, respectively) than in the M2 group (155.6±14.8μm and 151.6±12.5μm for right and left eyes, respectively) (P<.001). The One Use-Plus did not show a markedly better uniformity than the M2; the variation was mainly observed in the periphery. Multiple linear regression showed that for the One Use-Plus, the steeper the preoperative keratometry, the thicker the flap thickness, and for the M2, the thicker the preoperative pachymetry, the thicker the flap (P<.1).Conclusions:The One Use-Plus and M2 microkeratomes have similar safety and efficacy. The flap created by the One Use-Plus was much thinner than the flap created with the M2; however, the One Use-Plus can not realize a fully planar-shaped flap.
Development of a New Subjective Questionnaire: The Freedom from Glasses Value Scale (FGVS)
Authors: Lévy Pierre , Elies Dani , Dithmer Ole , Gil-Campos Irène , Benmedjahed Khadra , Berdeaux Gilles , Arnould Benoit 
Published: August 2010

Purpose:
To develop a patient self-administered questionnaire assessing the added value of complete independence from spectacles (hereafter referred to as glasses) after multifocal intraocular lens (IOL) surgery.

Methods:
Exploratory interviews with five cataract patients and six presbyopic patients with AcrySof ReSTOR IOLs (Alcon Laboratories Inc) implanted in both eyes for at least 6 months were conducted. The questionnaire’s conceptual framework was developed after interview analysis. Based on the identified concepts, items were generated simultaneously in French and Spanish using patients’ own words, and comprehension tested with six French patients; the Spanish questionnaire underwent clinician review and was further tested with four Spanish patients. French and Spanish versions were accordingly refined. The questionnaire was linguistically validated in UK English and Danish.

Results:
Interview analysis resulted in the identification of 9 global concepts: global vision, practical constraints related to wearing glasses, impact of eye surgery on the patient’s life, improvement of practical issues without glasses, improvement of psychological constraints without glasses, physical appearance/aesthetic aspect, self-image and in the eyes of others, eyesight problems left behind after surgery, and recommendation of surgery to others. The initial version of the test questionnaire contained 23 items; 2 items were deleted and changes were made after clinician review and patient testing. The final questionnaire named Freedom from Glasses Value Scale (FGVS) contained 21 items and four general additional questions.

Conclusions:
Beyond functional aspects, this qualitative study identified additional benefits in cataract and presbyopic patients living free of glasses after receiving multifocal IOLs. The FGVS now needs to be psychometrically validated (eg, construct validity and reliability).
Cutting Edge: Mutation of Francisella tularensis mviN Leads to Increased Macrophage Absent in Melanoma 2 Inflammasome Activation and a Loss of Virulence
Authors: Ulland Tyler K. , Buchan Blake W. , Ketterer Margaret R. , Fernandes-Alnemri Teresa , Meyerholz David K. , Apicella Michael A. , Alnemri Emad S. , Jones Bradley D. , Nauseef William M. , Sutterwala Fayyaz S. 
Published: August 2010

Abstract
The mechanisms by which the intracellular pathogen Francisella tularensis evades innate immunity are not well defined. We have identified a gene with homology to Escherichia coli mviN, a putative lipid II flippase, which F. tularensis uses to evade activation of innate immune pathways. Infection of mice with a F. tularensis mviN mutant resulted in improved survival and decreased bacterial burdens compared to infection with wild-type F. tularensis. The mviN mutant also induced increased absent in melanoma 2 inflammasome-dependent IL-1β secretion and cytotoxicity in macrophages. The compromised in vivo virulence of the mviN mutant depended upon inflammasome activation, as caspase 1- and apoptosis-associated speck-like protein containing a caspase recruitment domain-deficient mice did not exhibit preferential survival following infection. This study demonstrates that mviN limits F. tularensis-induced absent in melanoma 2 inflammasome activation, which is critical for its virulence in vivo.
Copy number variation analysis in single‐suture craniosynostosis: Multiple rare variants including RUNX2 duplication in two cousins with metopic craniosynostosis
Authors: Mefford Heather C. , Shafer Neil , Antonacci Francesca , Tsai Jesse M. , Park Sarah S. , Hing Anne V. , Rieder Mark J. , Smyth Matthew D. , Speltz Matthew L. , Eichler Evan E. , Cunningham Michael L. 
Published: August 2010

AbstractLittle is known about genes that underlie isolated single‐suture craniosynostosis. In this study, we hypothesize that rare copy number variants (CNV) in patients with isolated single‐suture craniosynostosis contain genes important for cranial development. Using whole genome array comparative genomic hybridization (CGH), we evaluated DNA from 186 individuals with single‐suture craniosynostosis for submicroscopic deletions and duplications. We identified a 1.1 Mb duplication encompassing RUNX2 in two affected cousins with metopic synostosis and hypodontia. Given that RUNX2 is required as a master switch for osteoblast differentiation and interacts with TWIST1, mutations in which also cause craniosynostosis, we conclude that the duplication in this family is pathogenic, albeit with reduced penetrance. In addition, we find that a total of 7.5% of individuals with single‐suture synostosis in our series have at least one rare deletion or duplication that contains genes and that has not been previously reported in unaffected individuals. The genes within and disrupted by CNVs in this cohort are potential novel candidate genes for craniosynostosis. © 2010 Wiley‐Liss, Inc.
Identification of genomic loci contributing to agenesis of the corpus callosum
Authors: O'Driscoll Mary C. , Black Graeme C. M. , Clayton‐Smith Jill , Sherr Elliott H. , Dobyns William B. 
Published: August 2010

AbstractAgenesis of the corpus callosum (ACC) is a common brain malformation of variable clinical expression that is seen in many syndromes of various etiologies. Although ACC is predominantly genetic, few genes have as yet been identified. We have constructed and analyzed a comprehensive map of ACC loci across the human genome using data generated from 374 patients with ACC and structural chromosome rearrangements, most having heterozygous loss or gain of genomic sequence and a few carrying apparently balanced rearrangements hypothesized to disrupt key functional genes. This cohort includes more than 100 previously unpublished patients. The subjects were ascertained from several large research databases as well as the published literature over the last 35 years. We identified 12 genomic loci that are consistently associated with ACC, and at least 30 other recurrent loci that may also contain genes that cause or contribute to ACC. Our data also support the hypothesis that many ACC loci confer susceptibility to other brain malformations as well as ACC, such as cerebellar hypoplasia, microcephaly, and polymicrogyria. The database presented here provides a valuable resource for diagnosis and management of individuals with ACC and individuals with chromosome rearrangements in whom ACC should be suspected, and of course for identifying ACC causal and contributory genes. Well‐defined diagnostic criteria, improved scanning techniques, and increased recognition of associated abnormalities will further facilitate gene mapping and allow definition of distinct syndromes within this heterogeneous group of patients. © 2010 Wiley‐Liss, Inc.
Gene expression patterns in the bone tissue of women with fibrous dysplasia
Authors: Kiss János , Balla Bernadett , Kósa János P. , Borsy Adrienn , Podani János , Takács István , Lazáry Áron , Nagy Zsolt , Bácsi Krisztián , Kis Adrián , Szlávy Eszter , Szendrői Miklós , Speer Gábor , Orosz László , Lakatos Péter 
Published: August 2010

AbstractFibrous dysplasia is an isolated skeletal disorder caused by a somatic activating mutation ofGNASgene with abnormal unmineralized matrix overproduction and extensive undifferentiated bone cell accumulation in the fibro‐osseous lesions. The aim of our investigation was to identify genes that are differently expressed in fibrous versus non‐fibrous human bone and to describe the relationships between these genes using multivariate data analysis. Six bone tissue samples from female patients with fibrous dysplastia (FD) and seven bone tissue samples from women without FD (non‐FD) were examined. The expression differences of selected 118 genes were analyzed by the TaqMan probe‐based quantitative real‐time RT‐PCR system. The Mann–WhitneyU‐test indicated marked differences in the expression of 22 genes between FD and non‐FD individuals. Nine genes were upregulated in FD women compared to non‐FD ones and 18 genes showed a downregulated pattern. These altered genes code for minor collagen molecules, extracellular matrix digesting enzymes, transcription factors, adhesion molecules, growth factors, pro‐inflammatory cytokines, and lipid metabolism‐affected substrates. Canonical variates analysis demonstrated that FD and non‐FD bone tissues can be distinguished by the multiple expression profile analysis of numerous genes controlled via a G‐protein coupled pathway and BMP cascade as well as genes coding for extracellular matrix composing molecules. The remarkable changed gene expression profile observed in the fibrous dysplastic human bone tissue may provide further insight into the pathogenetic process of fibrous degeneration of bone. © 2010 Wiley‐Liss, Inc.
Regulation of facial morphogenesis by endothelin signaling: Insights from mice and fish
Authors: Clouthier David E. , Garcia Elvin , Schilling Thomas F. 
Published: August 2010

AbstractCraniofacial morphogenesis is accomplished through a complex set of developmental events, most of which are initiated in neural crest cells within the pharyngeal arches. Local patterning cues from the surrounding environment induce gene expression within neural crest cells, leading to formation of a diverse set of skeletal elements. Endothelin‐1 (Edn1) is one of the primary signals that establishes the identity of neural crest cells within the mandibular portion of the first pharyngeal arch. Signaling through its cognate receptor, the endothelin‐A receptor, is critical for patterning the ventral/distal portion of the arch (lower jaw) and also participates with Hox genes in patterning more posterior arches. Edn1/Ednra signaling is highly conserved between mouse and zebrafish, and genetic analyses in these two species have provided complementary insights into the patterning cues responsible for establishing the craniofacial complex as well as the genetic basis of facial birth defect syndromes. © 2010 Wiley‐Liss, Inc.
Temple–Baraitser syndrome: A rare and possibly unrecognized condition
Authors: Jacquinet Adeline , Gérard Marion , Gabbett Michael T. , Rausin Léon , Misson Jean‐Paul , Menten Björn , Mortier Geert , Van Maldergem Lionel , Verloes Alain , Debray François‐Guillaume 
Published: August 2010

AbstractTemple–Baraitser syndrome, previously described in two unrelated patients, is the association of severe mental retardation and abnormal thumbs and great toes. We report two additional unrelated patients with Temple–Baraitser syndrome, review clinical and radiological features of previously reported cases and discuss mode of inheritance. Patients share a consistent pattern of anomalies: hypo or aplasia of the thumb and great toe nails and broadening and/or elongation of the thumbs and halluces, which have a tubular aspect. All patients were born to unrelated parents and occurred as a single occurrence in multiple sibships, suggesting sporadic inheritance from a de novo mutation mechanism. Comparative genomic hybridization in Patients 1, 2 and 3 did not reveal any copy number variations. We confirm that Temple–Baraitser syndrome represents a distinct syndrome, probably unrecognized, possibly caused by a de novo mutation in a not yet identified gene. © 2010 Wiley‐Liss, Inc.
Complex rearrangements between chromosomes 6, 10, and 11 with multiple deletions at breakpoints
Authors: Lee Ni‐Chung , Chen Ming , Ma Gwo‐Chin , Lee Dong‐Jay , Wang Tzu‐Jou , Ke Yu‐Yuan , Chien Yin‐Hsiu , Hwu Wuh‐Liang 
Published: August 2010

AbstractHere we report on a girl with minor facial anomalies, cleft palate, seizures, microcephaly, psychomotor retardation, and a congenital heart defect. Complex of cytogenetic methods [GTG‐banding, spectral karyotyping (SKY), fluorescence in situ hybridization (FISH), multicolor banding (mBAND), and comparative genomic hybridization (array CGH)] showed complex chromosomal rearrangements (CCRs) involving chromosomes 6, 10, and 11 and 4 deletions at the breakpoints. Her father had an unrelated translocation between chromosomes 3 and 16, suggesting the possibility of an autosomal dominant trait that predisposes to complex synapses and recombination between multiple chromosomes during meiosis. This study demonstrates the power of combining available chromosome analysis technologies in resolving CCR. © 2010 Wiley‐Liss, Inc.
Simulation of NOx Formation in Methane‐Air Turbulent Combustion Using an Improved Second‐Order Moment Model
Authors: Zheng C. G. , Zhou L. X. , Yin J. 
Published: August 2010

AbstractThe NOx formation in methane‐air turbulent combustion is simulated using an improved second‐order moment (NSOM) model of turbulence‐chemistry interaction. The predicted results from three different versions of the presumed probability density function (PDF) model are compared with the experimental data from the literature. The results show that the NSOM model with algebraic expression of second‐order moments is as good as the proposed PDF model using transport equations of second‐order moments, but the former needs much less computation time than the latter. Therefore, the NSOM model can be used to simulate turbulent combustion and NOx formation with detailed known chemistry, while the proposed PDF model is more difficult to apply.
Heat and Mass Transfer Model Including Shrinkage Applied to Ellipsoidal Products: Case Study for Drying of Bananas
Authors: De Lima A.G.B. , Queiroz M.R. , Nebra S.A. 
Published: August 2010

AbstractThis paper presents an investigation of the simultaneous heat and mass transfer in solids with prolate spheroidal shape. A two‐dimensional unsteady diffusion model applied to a prolate spheroid is presented assuming that liquid diffusion is the sole mechanism of moisture transport, with convective and evaporative boundary conditions at the surface of the solid. The resulting equations were solved numerically using the finite‐volume method. To validate the numerical model, results of the mean moisture content and center temperature were compared with experimental data on banana drying and good results were achieved. The convective and transport coefficients were obtained by fitting the model with experimental data using the least squares error method.
Incorporating a concept of altruism into psychoanalytic theory
Authors: Nielsen Mary L. 
Published: August 2010

AbstractThis paper proposes the existence of an intrinsic, non‐conflictual altruistic impulse, and presents arguments from human behavior studies, evolutionary theory, attachment theory, and psychoanalytic writings to support this thesis. Altruism has been previously regarded as a defensive phenomenon based on assumptions about the superego, competitiveness, individualism, and self‐interested libido. This paper proposes that the element of primary other‐orientedness makes possible a non‐neurotic component of oedipal resolution, based on triadic love. Finally, the paper defines remorse as an altruistic or other‐oriented repair. Copyright © 2010 John Wiley & Sons, Ltd.
State estimation for multi‐channel stochastic singular systems with multiplicative noise
Authors: Chu Dongsheng , Gao Shouwan , Guo Lina 
Published: August 2010

AbstractThe state estimation problem for multi‐channel singular systems with multiplicative noise is considered based on singular value decomposition. First, two equivalent reduced order subsystems are obtained via the decomposition. Then, in order to solve the estimation problem, the subsystems are rewritten into a new form. It is noted that the measurement noise here becomes colored noise, which contains the dynamic noise, measurement noise, and multiplicative noise of the original system. In this situation, existing filtering methods cannot be directly applied, so a modified filtering method is given. The recursive algorithm for the state estimation is obtained by the filtering method. In addition, the estimation of dynamic noise is derived via the algorithm. A simulation example is given to show the effectiveness of the proposed algorithm.Copyright © 2010 John Wiley and Sons Asia Pte Ltd and Chinese Automatic Control Society
Global set‐point tracking control for a class of nonlinear systems with iISS inverse dynamics
Authors: Yu Jiang‐Bo , Wu Yu‐Qiang 
Published: August 2010

AbstractIn this paper, we consider the problem of global set‐point tracking control for a class of nonlinear systems with dynamic uncertainty. Unlike the existing works, the investigated system is with the integral input‐to‐state stable (iISS) inverse dynamics and more general uncertain nonlinearities. By using a recursive design method, a partial‐state feedback controller is designed. The tuning function technique is applied in this procedure to avoid the overparametrization. It is shown that the developed control procedure could guarantee that the tracking error is driven to the origin and the other signals are bounded. In addition, it can also reduce to a linear or even a classical PI control law under some sufficient conditions. Simulation results are illustrated to show the effectiveness of the proposed algorithm.Copyright © 2010 John Wiley and Sons Asia Pte Ltd and Chinese Automatic Control Society
Urban tracer dispersion experiment in London (DAPPLE) 2003: field study and comparison with empirical prediction
Authors: Martin D. , Nickless G. , Price C.S. , Britter R.E. , Neophytou M.K. , Cheng H. , Robins A.G. , Dobre A. , Belcher S.E. , Barlow J.F. , Tomlin A.S. , Smalley R.J. , Tate J.E. , Colvile R.N. , Arnold S.J. , Shallcross D.E. 
Published: August 2010

AbstractThe DAPPLE (Dispersion of Air Pollutants and their Penetration into the Local Environment) project seeks to characterise near‐field urban atmospheric dispersion using a multidisciplinary approach. In this paper we report on the first tracer dispersion experiment carried out in May 2003. Results of concurrent meteorological measurements are presented. Variations of receptor tracer concentration with time are presented. Meteorological observations suggest that in‐street channelling and flow‐switching at intersections take place. A comparison between roof top and surface measurements suggest that rapid vertical mixing occurs, and a comparison between a simple dispersion model and maximum concentrations observed are presented. Copyright © 2010 Royal Meteorological Society
Association of folate receptor (folr1, folr2, folr3) and reduced folate carrier (slc19a1) genes with meningomyelocele
Authors: O'Byrne Michelle R. , Au Kit Sing , Morrison Alanna C. , Lin Jone‐Ing , Fletcher Jack M. , Ostermaier Kathryn K. , Tyerman Gayle H. , Doebel Sabine , Northrup Hope 
Published: August 2010

AbstractBackgroundMeningomyelocele (MM) results from lack of closure of the neural tube during embryologic development. Periconceptional folic acid supplementation is a modifier of MM risk in humans, leading toan interest in the folate transport genes as potential candidates for association to MM.METHODSThis study used the SNPlex Genotyping (ABI, Foster City, CA) platform to genotype 20 single polymorphic variants across the folate receptor genes (FOLR1, FOLR2, FOLR3) and the folate carrier gene (SLC19A1) to assess their association to MM. The study population included 329 trio and 281 duo families. Only cases with MM were included. Genetic association was assessed using the transmission disequilibrium test in PLINK.RESULTSA variant in the FOLR2 gene (rs13908), three linked variants in the FOLR3 gene (rs7925545, rs7926875, rs7926987), and two variants in the SLC19A1 gene (rs1888530 and rs3788200) were statistically significant for association to MM in our population.CONCLUSIONThis study involved the analyses of selected single nucleotide polymorphisms across the folate receptor genes and the folate carrier gene in a large population sample. It provided evidence that the rare alleles of specific single nucleotide polymorphisms within these genes appear to be statistically significant for association to MM in the patient population that was tested. Birth Defects Research (Part A), 2010. © 2010 Wiley‐Liss, Inc.