bluuebunny/crossref_metadata_2025_split huggingface dataset:
Abelson Tyrosine Kinase Inhibitors in Parkinson's Disease and Lewy Body Dementia: A Systematic Review, Meta-analysis, and Meta-regression
Authors: Gosch Berton Giovanni , Cyntia Lima Fonseca Rodrigues Amanda , dos Santos Borges Rafael , Rodrigues Cardoso Nicole , de Oliveira Thiago Abrahão , Oliveira Marques Marcos Vinícius 
Published: May 2024

Background
Alpha-synucleinopathies are incurable neurodegenerative diseases. Abelson tyrosine kinase inhibitors (Abl TKIs) may be disease-modifying therapies. This systematic review, meta-analysis, and meta-regression evaluated the use of Abl TKIs in their treatment.

Methods
We searched PubMed, Embase, and Cochrane databases for trials using Abl TKIs in patients with Parkinson's disease and Lewy body dementia published until July 2023. The outcome was the change in the MDS-UPDRS-III (Movement Disorder Society–Sponsored Revision of the Unified Parkinson's Disease Rating Scale III). DerSimonian-Laird random-effects model was used to calculate the pooled effect estimates. Leave-one-out forest plots were used for the sensitivity analysis, and meta-regression (restricted maximum likelihood) was performed.

Results
Five studies (197 patients) were included. Nilotinib 300 mg had an effect size of −1.154 (95% confidence interval [CI], −3.000 to 0.692). Nilotinib 150 mg and bosutinib 100 mg versus placebo yielded 0.82 (95% CI, −3.76 to 5.41). Sensitivity analysis showed that 1 trial changed the significance of the nilotinib 300 mg single-arm analysis (MD = −1.723; 95% CI, −2.178 to −1.268). Meta-regression revealed that lower age (EC = −0.9103, SE = 0.2286, P < 0.0001) and higher baseline MDS-UPDRS-III scores (EC = 0.1210, SE = 0.0168, P < 0.0001) could explain the inefficacy of nilotinib 300 mg.

Conclusions
Nilotinib (300 mg) proved effective postsensitivity analysis, unlike lower doses and bosutinib in Parkinson's disease/Lewy body dementia. Abl TKIs showed reduced efficacy in younger, more impaired patients, indicating the need for further testing with higher-potency drugs in patients who have diseases that are in the early stage but with a later onset.
Compartmentalization of Transcripts During Antibody Mediated Rejection in Renal Transplants
Authors: Margeta Dajana , Noguchi Hirotsugu , Khazaie Sepideh , Herlitz Leal C. , Augustine Joshua J. , Heeger Peter S. , Tambur Anat R. , Fairchild Robert L. , Baldwin William M. 
Published: May 2024

AbstractWe used Digital Spatial Profiling to localize transcripts in glomeruli and tubulointerstitial compartments in a series of 4 biopsies from a patient diagnosed with acute antibody-mediated rejection (AMR). The 4 biopsies included: a baseline protocol biopsy 25 days after transplantation; a 3 month biopsy diagnosed as acute AMR; a biopsy 4 months after treatment with intravenous immunoglobulin (IVIg) showing ongoing AMR with a mild increase in tubulointerstitial fibrosis; and a biopsy 7 months later with resolution of glomerulitis. Glomeruli were captured in regions of interest (ROIs) for whole exome sequencing. Compared to baseline glomeruli, 17 transcripts were increased and 39 decreased in the 3 subsequent biopsies (> 2-fold and p < 0.005). Increased signatures for macrophages correlated with increased numbers of CD68 positive cells imaged in the corresponding glomeruli. The Human Cell Atlas classified the 39 transcripts decreased during the initial rejection as characteristic of podocytes and this gene signature did not recover in the subsequent 2 biopsies. Additional ROIs encompassing areas of tubulointerstitial fibrosis disclosed signatures for memory B cells in the acute AMR sample. Treatment with IVIg did not eliminate the B cell signal in the subsequent biopsy.Collectively these data demonstrate a compartmentalization of injury processes. Innate immune cells including macrophages were located in glomerular and tubulointerstitial compartments, whereas, adaptive immune cells including memory B cells localized to the tubulointerstitial compartment. Furthermore, podocyte transcripts were decreased in glomeruli and did not recover with treatment indicating a vulnerability of these cells to acute AMR.
A Cell-Based Papain-like Protease (PLpro) Activity Assay for Rapid Detection of Active SARS-CoV-2 Infections and Antivirals
Authors: Jimenez-Campos Anahi G. , Maestas Lucas I. , Velappan Nileena , Beck Brian , Ye Chunyan , Wernsing Keith , Mata-Solis Yaniksa , Bruno William J. , Bussmann Silas C. , Bradfute Steven , Baca Justin T. , Rininsland Frauke H. 
Published: May 2024

AbstractSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and its variants are a continuous threat to human life and prosperity. An urgent need remains for simple and fast tests that reliably detect active infections with SARS-CoV-2 and its variants in asymptomatic and presymptomatic carriers. Here we introduce a simple and rapid activity-based diagnostic (ABDx) test that identifies SARS-CoV-2 infections by measuring the activity of a viral enzyme, Papain-Like protease (PLpro). The test system consists of a peptide that fluoresces when cleaved by SARS PLpro that is active in crude, unprocessed lysates from human tongue scrapes and saliva. Test results are obtained in 30 minutes or less using widely available fluorescence plate readers, or a battery-operated portable instrument for testing at point of care (PoC) sites and in low-resource and hard to reach populations. Proof-of-concept was obtained in a clinical study on clinical specimens collected from patients with COVID-19 like symptoms who tested positive (n=10) or negative (n=10) with diagnostic LIAT RT-PCR using nasal mid turbinate swabs. When saliva from these patients was tested with in-house endpoint RT-PCR only 3 specimens were negative and 17 were positive. PLpro activity correlated in 17 of these cases (3 out of 3 negatives and 14 out of 16 positives, with one invalid specimen. Despite the small number of samples, the agreement was significant (p value = 0.01). In one presumptive false positive patient viral RNA was detected in saliva 5 days later by endpoint RT-PCR. Two false negatives were detected, one from a sample with a late Ct value of 35 in diagnostic RT-PCR, indicating that an active infection was no longer present. The PLpro activity assay is easily scalable and expected to detect all viable SARS-CoV-2 variants and recombinants, making it attractive as a screening and surveillance tool. Additionally, we show feasibility of the platform as a new homogeneous phenotypic assay for rapid screening of SARS-CoV-2 antiviral drugs and neutralizing antibodies.
Temporal-Coherence Induces Binding of Responses to Sound Sequences in Ferret Auditory Cortex
Authors: Lu Kai , Dutta Kelsey , Mohammed Ali , Elhilali Mounya , Shamma Shihab 
Published: May 2024

ABSTRACTBinding the attributes of a sensory source is necessary to perceive it as a unified entity, one that can be attended to and extracted from its surrounding scene. In auditory perception, this is the essence of the cocktail party problem in which a listener segregates one speaker from a mixture of voices, or a musical stream from simultaneous others. It is postulated that coherence of the temporal modulations of a source’s features is necessary to bind them. The focus of this study is on the role of temporal-coherence in binding and segregation, and specifically as evidenced by the neural correlates of rapid plasticity that enhance cortical responses among synchronized neurons, while suppressing them among asynchronized ones. In a first experiment, we find that attention to a sound sequence rapidly binds it to othercoherentsequences while suppressing nearbyincoherentsequences, thus enhancing the contrast between the two groups. In a second experiment, a sequence of synchronized multi-tone complexes, embedded in a cloud of randomly dispersed background of desynchronized tones, perceptually and neurally pops-out after a fraction of a second highlighting the binding among its coherent tones against the incoherent background. These findings demonstrate the role of temporal-coherence in binding and segregation.
Occupancy of the HbYX hydrophobic pocket is sufficient to induce gate opening in the archaeal 20S proteasomes
Authors: Chuah Janelle J.Y. , Daugherty Madalena R. , Smith David M. 
Published: May 2024

ABSTRACTEnhancing proteasome function has been a long-standing but challenging target of interest for the potential treatment of neurodegenerative diseases, emphasizing the importance of understanding proteasome activation mechanisms. Most proteasome activator complexes use the C-terminal HbYX (hydrophobic-tyrosine-almost any residue) motif to bind and trigger gate-opening in the 20S proteasome. This study defines a critical molecular interaction in the HbYX mechanism that triggers gate opening. We focus on the Hb site interaction and find it plays a surprisingly central and crucial role in driving the allosteric conformational changes that induce gate opening in the archaeal 20S. We examined the cryo-EM structure of two mutant archaeal proteasomes, αV24Y T20S and αV24F T20S. These two mutants were engineered to place a bulky aromatic residue in the HbYX hydrophobic pocket; both mutants are highly active, though their mechanisms of activation are undefined. Collectively, our findings indicate that the interaction between the Hb group of the HbYX motif and its corresponding hydrophobic pocket is sufficient to induce gate opening in a mechanistically similar way to the HbYX motif. The activation mechanism studied here involves the expansion of the hydrophobic binding site, allosterically altering the state of the IT switch thus triggering gate-opening. Furthermore, we show that the canonical αK66 residue, previously understood to be critical for proteasome activator binding, also plays a key role in stabilizing the open gate, irrespective of activator binding. This study differentiates between the residues in the HbYX motif that support binding interactions (“YX”) versus those that allosterically contribute to gate opening (“Hb”). The insights reported here will guide future drug development efforts, particularly in designing small molecule proteasome activators, by targeting the identified hydrophobic pocket.
State-resolved mutual neutralization of
O+16
with
H−1
and
H−2
at collision energies below 100 meV
Authors: Schmidt-May Alice F. , Barklem Paul S. , Grumer Jon , Amarsi Anish M. , Björkhage Mikael , Blom Mikael , Dochain Arnaud , Ji MingChao , Martini Paul , Reinhed Peter , Rosén Stefan , Simonsson Ansgar , Zettergren Henning , Cederquist Henrik , Schmidt Henning T. 
Published: May 2024

We measured the product-state distribution and its dependence on the hydrogen isotope for the mutual neutralization between O+16 and H−1,2 at the double electrostatic ion-beam storage ring DESIREE for center-of-mass collision energies below 100 meV. We find at least six product channels into ground-state hydrogen and oxygen in different excited states. The majority of oxygen products populate terms corresponding to 2s22p3(4S∘)4s with S∘5 as the main reaction product. We also observe product channels into terms corresponding to 2s22p3(4S)3p. Collisions with the heavier hydrogen isotope yield a branching into these lower excited states smaller than collisions with H−1. The observed reaction products agree with the theoretical predictions. The detailed branching fractions, however, differ between the theoretical results, and none of them fully agree with the experiment.

Published by the American Physical Society
2024
Use of HIS in achieving preventive care performance: a resource orchestration study
Authors: Mohd Fadhil Noor Fadzlina , Teoh Say Yen , Young Leslie W. , Wickramasinghe Nilmini 
Published: May 2024

PurposeThis study investigated two key aspects: (1) how a hospital bundles limited resources for preventive care performance and (2) how to develop IS capabilities to enhance preventive care performance.Design/methodology/approachA case study method was adopted to examine how a hospital integrates its limited resources which leads to the need for resource bundles and an understanding of IS capabilities development to understand how they contribute to the delivery of preventive care in a Malaysian hospital.FindingsThis research proposes a comprehensive framework outlining resource-bundling and IS capabilities development to improve preventive care.Research limitations/implicationsWe acknowledge that the problem of transferring and generalizing results has been a common criticism of a single case study. However, our objective was to enhance the reader’s understanding by including compelling, detailed narratives demonstrating how our research results offer practical examples that can be generalized theoretically. The findings also apply to similar-sized public hospitals in Malaysia and other developing countries, facing challenges like resource constraints, HIS adoption levels, healthcare workforce shortages, cultural and linguistic diversity, bureaucratic hurdles, and specific patient demographics and health issues. Further, lessons from this context can be usefully applied to non-healthcare service sector domains.Practical implicationsThis study provides a succinct strategy for enhancing preventive care in Malaysian public hospitals, focusing on system integration and alignment with hospital strategy, workforce diversity through recruitment and mentorship, and continuous training for health equity and inclusivity. This approach aims to improve resource efficiency, communication, cultural competence, and healthcare outcomes.Social implicationsEfficiently using limited resources through HIS investment is essential to improve preventive care and reduce chronic diseases, which cause approximately nine million deaths annually in Southeast Asia, according to WHO. This issue has significantly impacted the socioeconomic development of developing countries.Originality/valueThis research refines resource orchestration theory with new mechanisms for resource mobilization, extends IS literature by identifying how strategic bundling forms specialized healthcare IS capabilities, enriches preventive care literature through actionable resource-bundling activities, and adds to HIS literature by advocating for an integrated, preventive care focus from the alignment of HIS design, people and institutional policies to address concerns raised by other research regarding the utilization of HIS in improving the quality of preventive care.
Short video narratives, brand equity dimensions and horti-tourism patronage: does real-world video matter?
Authors: Mohammed Iddrisu , Mahmoud Mahmoud Abdulai , Hinson Robert Ebo 
Published: May 2024

PurposeUsing the transportation theory, and the brand equity model, this study aims to examine how short video narratives from a tourist perspective increased brand equity dimensions which could lead to intention to patronise. Further, the study tested the moderating role of real-world video between the brand equity dimensions and intention to patronise.Design/methodology/approachA sequential explanatory mixed method is adopted for this study. An empirical study was conducted in the first phase with 1,119 participants. In the second phase, the quantitative results were used to develop a semi-structured interview guide for in-depth interviews with 9 respondents to validate the quantitative outcomes. The structural equation modelling technique was utilised to analyse the quantitative data, whereas content analysis was used for the qualitative data.FindingsThe results revealed that short video narratives lead to horti-awareness, image and value. Additionally, horti-awareness, and value had a significant impact on intention to patronise horti-tourism destinations. Another interesting observation is that the negative perceived quality might be as a result of the short video emanating from a tourist perspective. Importantly, potential tourists perceived the real-world video to be authentic, thus strengthening the relationship between the brand equity dimensions and intention to patronise.Practical implicationsThis research provided valuable insights for marketers/management and stakeholders within the tourism and hospitality sector to achieve benefits derived from the findings of the study.Originality/valueTo the best of the authors knowledge, this study is the first attempt to embed the theory of transportation and the brand equity model in understanding horti-tourism destinations, which can rarely be found in extant literature.
Religiosity as an intervening variable in consumers’ increased green purchase intention (GPI) toward natural dye batik in Indonesia
Authors: Susminingsih Susminingsih , Mujib Abdul , Wahdati Anis , Baharuddin Mochammad Achwan , Maylawati Dian Sa'adillah 
Published: May 2024

Purpose
This study aims to examine the factors that influence the increase in purchase intention toward green batik products with religiosity as an intervening variable.

Design/methodology/approach
The study used a survey method that involved a sample size of 185 participants selected through purposive and accidental sampling techniques. The analysis was conducted by using IBM SPSS AMOS 21 software. The collected data were subjected to path analysis using multiple linear regression models.

Findings
The result indicated that religiosity plays a mediating role in the association between factors and the intention to purchase green product (GPd) of the Indonesian natural dye batik product. This finding is in accordance with the construction of theory of planned behavior in understanding consumer purchase intentions. GPd, green brand and green price exhibited a positive correlation with green purchase intention (GPI). Interestingly, the price was found to no longer serve as the primary factor in GPI.

Research limitations/implications
The analysis would have been more compelling if it had used a mixed-method approach by introducing the variables of customer satisfaction and promotion.

Practical implications
This research postulates that increased prices are no longer a deterrent to the purchase of GPd. Instead, consumer consciousness regarding GPd plays a pivotal role in driving GPI. GPd have revolutionized individuals’ consumption patterns to contribute to environmental preservation. The use of green batik products is seen as advantageous in helping mitigate environmental degradation.

Originality/value
The present research assesses the impact of religiosity, as an intervening variable, on the augmentation of GPI by gauging its significance in enhancing ecological consciousness and moral values.
Study on site selection evaluation of emergency material storage based on improved TOPSIS
Authors: Pang Xiaona , Yang Wenguang , Miao Wenjing , Zhou Hanyu , Min Rui 
Published: May 2024

PurposeThrough the scientific and reasonable evaluation of the site selection of the emergency material reserve, the optimal site selection scheme is found, which provides reference for the future emergency decision-making research.Design/methodology/approachIn this paper, we have chosen three primary indicators and twelve secondary indicators to construct an assessment framework for the determination of suitable locations for storing emergency material reserves. By mean of the improved entropy weight-order relationship weight determination method, the evaluation model of kullback leibler-technique for order preference by similarity to an ideal solution (KL-TOPSIS) emergency material reserve location based on relative entropy is established. On this basis, 10 regional storage sites in Beijing are selected for evaluation.FindingsThe results show that the evaluation model of the location of emergency material reserve not only respects the objective knowledge, but also considers the subjective information of the experts, which makes the ranking result of the location of the emergency material reserve more accurate and reliable.Originality/valueFirstly, the modification factor is added to the calculation formula of traditional entropy weight method to complete the improvement of entropy weight method. Secondly, the order relation analysis method is used to assign subjective weights to the indicators. The principle of minimum information entropy is introduced to determine the comprehensive weight of the index. Finally, KL distance and TOPSIS method are combined to determine the relative entropy and proximity degree of alternative solutions and positive and negative ideal solutions, and the scientific and effective of the method is proved by case study.
A synthetic difference-in-differences model for the influence of CR Express on Chongqing’s economy
Authors: Zhang Rong , Li Qi 
Published: May 2024

PurposeThe China–Europe Railway Express (CR Express) in Chongqing has operated regularly and undergone large-scale development. Its impact on Chongqing’s economic growth has become increasingly evident, necessitating further research in this field.Design/methodology/approachThis study employs the opening of CR Express as a quasi-natural experiment, designating Chongqing, which inaugurated the CR Express in 2011, as the treatment group. 13 provinces and cities that had not yet opened the CR Express until 2017 were selected as the control group. Utilizing panel data from 14 provinces across China spanning from 2006 to 2017, the synthetic control method (SCM) is employed to synthetically construct Chongqing. To quantify the difference in economic development levels between Chongqing with the operation of the CR express and Chongqing without its operation. Key metrics such as gross domestic product (GDP), per capita GDP, total retail sales of consumer goods, import and export value and the proportions of the secondary and tertiary industries are employed to measure urban economic development capabilities. Chongqing is designated as the experimental group, and a double-difference model is constructed to regress the operation of the CR Express against economic development capabilities. Robustness tests are conducted to validate the analytical results.FindingsThe results indicate that, compared to provinces without the operation of the CR Express, the initiation of the CR Express in Chongqing significantly enhances the economic development level of the city. The opening of the CR Express exhibits a pronounced positive impact on Chongqing’s economic development, and these findings remain robust and effective even after parallel trend tests and placebo tests.Originality/valueThe study represents an expansion of the theoretical framework. In contrast to previous studies that relied on a single indicator such as GDP, this study selects six indicators from the dimensions of economy, trade and industry to measure regional economic development capabilities. Furthermore, employing the grey relational analysis method, the study screens these indicators, thereby providing a theoretical basis for the selection of indicators for measuring regional economic development capabilities.