bluuebunny/crossref_metadata_2025_split huggingface dataset:
HIPEC application potential in the treatment of extensive carcinomatosis in ovarian cancer (retrospective study)
Authors: Radostev S. I. , Kolomiets L. A. , Shelekhov A. V. , Zubkov R. A. , Morikov D. D. , Medvednikov А. A. 
Published: June 2024

Background. The high prevalence of advanced forms of cancer currently requires new treatment approaches. Only modern high-tech surgical procedures can provide means for improving the results of treatment.The aim. To study the results of treatment of patients with ovarian cancer with symptoms of peritoneal carcinomatosis using the HIPEC (Hyperthermic IntraPEritoneal Chemotherapy) method.Materials and methods. The study was conducted in Irkutsk Regional Cancer Center and included 88 patients. They were divided into 2 groups: group 1 – primary cytoreductive surgery (CRS) with the HIPEC method (41 patients); group 2 – primary cytoreductive surgery (47 patients). The most important criterion was the peritoneal cancer index (PCI). If the PCI was ≤ 14, we chose cytoreductive surgery with or without HIPEC.Results. PCI analysis showed differences in its values between the study groups (CRS – 10.17 ± 0.952; CRS + HIPEC – 12.93 ± 0.744; p = 0.002). There was an increase in length of stay in patients who underwent major surgeries in combination with HIPEC (21.8 ± 0.9 days versus 14.5 ± 0.6 days in the CRS group; p = 0.001). The CRS + HIPEC group had a longer duration of surgery (394.88 ± 19.935 min vs. 172.98 ± 11.514 min in the CRS group; p = 0.001). There was an increase in the overall percentage of postoperative complications in the CRS + HIPEC group – up to 26.8 % without statistically significant differences with the CRS group – 8.5 % (p = 0.082). The median time of relapse onset in the CRS + HIPEC group was 26 ± 4.3 months, while in the CRS group it was 18 ± 2.6 months.Conclusion. Using HIPEC method has proven its significance in increasing diseasefree survival.
Histological features of the structure of the long head of biceps brachii tendon in patients with concomitant injuries of the rotator cuff
Authors: Kolmakov D. O. , Zagorodniy N. V. , Korolev A. V. , Ilyin D. O. , Ushkova O. G. 
Published: June 2024

Background. The long head of biceps brachii tendon plays an important role in shoulder pain. Surgical tactics remain controversial. There are two approaches: tenotomy of the long head of biceps brachii tendon and tenodesis. Both have positive and negative sides. There is also no consensus on the effective position for performing tenodesis.The aim. To assess the histological structure of various parts of the long head of biceps brachii tendon, which may be the causes for persistent pain syndrome.Materials and methods. In this study, we examined the histological structure of the long head of biceps brachii tendon in 12 patients aged 18–59 years having chronic anterior shoulder pain with concomitant damage to the supraspinatus and subscapularis tendons. In all cases, magnetic resonance imaging (MRI) revealed changes that made it impossible to perform intraarticular tenodesis. Patients were divided into two groups according to the World Health Organization classification: young (18–44 years) and middle-aged (45–59 years). All patients underwent arthroscopy with subpectoral tenodesis and correction of concomitant pathology. The obtained macropreparations are divided into three zones: the proximal zone, the intertubercular zone and the zone below the intertubercular groove. All macropreparations were sent for histological examination.It was revealed that the most common changes occur in the area of the intertubercular groove in all categories, however, in the middle-aged group, the signs of inflammation and degeneration are equally evident in this zone and in the proximal part of the tendon.Conclusions. Young and middle-aged patients with damage to the tendons of the supraspinatus and subscapularis muscles and signs of chronic tendinitis of the long head of biceps brachii tendon tendon and pronounced structural changes according to MRI should undergo a subpectoral tenodesis procedure; it is also necessary to take into account the anatomical features of the tendon and possible surgical risks.
Assessment of the therapeutic effect of the drug Molixan in the treatment of Syrian hamsters experimentally infected with the SARS-CoV-2 virus
Authors: Gulyaeva M. A. , Shestopalova L. V. , Din X. , Alekseev A. Yu. , Markhaev A. G. , Filippova А. Yu. , Antonov V. G. , Trashkov A. P. , Shestopalov A. M. 
Published: June 2024

Background. Studying the characteristics of the course of coronavirus infection caused by SARS-CoV-2 remains relevant due to the high mutagenicity of the virus and the prevalence of the disease in the world. The search for new drugs to eliminate clinical manifestations of COVID-19, as well as against its agent, is essential. During the pandemic caused by SARS-CoV-2, dexamethasone was recognized as the only effective anti-inflammatory drug for the treatment of patients with severe form of the disease, but its use leads to a large number of side effects.The aim. To study the therapeutic effect of the drug Molixan in the treatment of coronavirus infection in model animals – Syrian hamsters.Methods. To assess the effectiveness of the drug Molixan, we carried out a visual assessment of the condition of the lungs using light microscopy and the morphometry of the lung tissue of experimentally infected Syrian hamsters on the day 6 after infection under different Molixan treatment regimens and during dexamethasone therapy. The test drug was administered using three different doses (22.2 mg/kg, 44.4 mg/kg and 88.8 mg/kg, which are equivalent to doses of 3 mg/kg, 6 mg/kg and 12 mg/kg of human body weight) once daily or dividing the dose into two within 12 h interval in case of multiple (5 days) intramuscular administration. Dexamethasone (comparison drug) was administered at a dose of 20 mg/kg once daily for 5 days.Results. The studies showed statistically significant effectiveness of using Molixan at a dose of 44.4 mg/kg, divided into two doses, during 5 days. When compared with untreated hamsters, this treatment regimen reduces the degree of generalization and severity of the inflammatory process in the lungs; and the pathomorphological picture is similar to that observed during treatment with Dexamethasone.Conclusion. The studied drug Molixan is effective as an anti-inflammatory drug in the treatment of the disease caused by SARS-CoV-2.
Pharmaceutical composition of 1,2,4-trioxolanes with betulin in fish oil. Effect on oxidative and energy metabolism in the treatment of burns in rats
Authors: Malygina D. S. , Yastrebov P. V. , Fayans A. E. , Spitskaya I. V. , Esipovich A. L. , Soloveva А. G. , Peretyagin P. V. , Melnikova N. B. 
Published: June 2024

Background. Ozonation products of unsaturated fatty acids in fats and oils – 1,2,4-trioxolanes – which contribute to the normalization of oxidative and energy metabolism in various diseases, may be a promising substance for the creation of new combined anti-burn drugs.The aim. To study the effect of 1,2,4-trioxolanes in a pharmaceutical composition with betulin, which exhibits wound-healing properties, on indicators of oxidative stress and on energy metabolism in the treatment of burns in an experiment onrats. Methods. The experiments were carried out on 50 male Wistar rats with seconddegree skin burns. We assessed the activity of glutathione reductase, glucose-6-phosphate dehydrogenase, lactate dehydrogenase, aldehyde dehydrogenase, superoxide dismutase and catalase, as well as the level of lipid peroxidation indicators.Results. The properties of 1,2,4-trioxolanes were studied and a pharmaceutical composition of 1,2,4-trioxolanes with betulin from birch bark in fish oil was developed. The effect of this composition on oxidative and energy metabolism in rats during the treatment of burns was studied. The activation of NADP/H and NAD/H dependent enzymes (glutathione reductase, glucose-6-phosphate dehydrogenase, lactate dehydrogenase, aldehyde dehydrogenase), as well as superoxide dismutase and catalase, and the normalization of lipid peroxidation parameters under the influence of the studied composition in the treatment of burns were revealed. The effect of the composition on the energy metabolism of erythrocytes was noted, which was assessed by changes in the ratio of lactate dehydrogenase activity in the reverse and direct reactions. Morphohistological studies showed that using the composition under normal conditions and in case of a burn had no effect on the structure of the stomach wall, and also improved the condition of the burn wound on the day 10 compared to the wound condition in animals without treatment.Conclusion. The proposed composition of 1,2,4-trioxolanes and betulin in fish oil, which allows normalizing oxidative and energy metabolism and improving the condition of a burn wound without toxic effects on the stomach wall, can be used as an element of additional therapy in the treatment of burns.
Clinical case of pregnancy complicated by thrombotic thrombocytopenic purpura
Authors: Semenova M. V. , Sarrakhov D. D. , Gilimkhanova A. R. , Kamalova A. R. , Vakhitov P. G. , Musina А. A. , Islamgaraev B. A. 
Published: June 2024

Background. Thrombotic thrombocytopenic purpura is a rare blood disease characterized by increased thrombogenesis in the microcirculation. One of the most common triggers for the development of this disease is pregnancy. The article describes a case of pregnancy complicated by thrombotic thrombocytopenic purpura.Materials and methods. To assess the clinical case, we used a retrospective analysis of medical documentation: maternity case record, birth history, results of laboratory and instrumental research methods.Results. A 32-year-old patient was admitted to hospital at week 32 of gestation with manifestations of moderate preeclampsia, thrombocytopenia, and moderate anemia. Due to worsening of the condition, the delivery was performed by cesarean section. Subsequently, the mother’s condition did not improve: thrombocytopenia and hyperbilirubinemia progressed; the level of transaminases increased; ADAMTS13 activity was 8 %. Teleconferences were repeatedly held with experts from the National Medical Research Center for Obstetrics, Gynecology and Perinatology named after Academician V.I. Kulakov (Moscow). Complex therapy including extracorporeal methods led to a positive result; the patient was discharged in satisfactory condition under the supervision of a hematologist and obstetrician-gynecologist.Conclusion. Thrombotic thrombocytopenic purpura treatment tactics have its own characteristics; it is necessary to diagnose this pathology in a timely manner to provide qualified medical care and to prevent maternal and perinatal losses.
Clinical and laboratory prognostic factors in patients with mixed infection of erythema form of ixodic tick-borne borreliosis and tick-borne encephalitis
Authors: Ilyinskikh E. N. , Filatova E. N. , Semenova A. V. , Samoylov K. V. , Portnyagina E. V. , Minakova Iu. V. , Kolganova G. N. 
Published: June 2024

Background. Early diagnosis of the mixed infection of ixodic tick-borne borreliosis and tick-borne encephalitis can be difficult without laboratory confirmation of the diagnosis.The aim. To assess clinical and laboratory predictors in patients for building the models of early differential diagnosis between mixed infection of erythema form of ixodic tick-borne borreliosis and febrile form of tick-borne encephalitis and monoinfection of erythema form of ixodic tick-borne borreliosis.Materials and methods. The clinical study included 26 patients with mixed infection of the erythema form of ixodic tick-borne borreliosis with tick-borne encephalitis (mean age – 46.7 years) and 30 patients with monoinfection of the erythema form of ixodic tick-borne borreliosis (mean age – 48.5 years). 59 clinical, epidemiological and laboratory parameters, including 6 leukocyte blood indices, standard and extended hemogram profiles were studied in these patients the first week of the disease. For statistical analysis, we used Pearson and Mann – Whitney goodness-of-fit tests, ROC analysis with calculation of the area under curve (AUC) and logistic regression. Results. Patients with mixed infection, compared to the patients with monoinfection, had increased odds of having febrile fever, weakness, headache and orbital pain; meningism symptoms occurred only in patients with mixed infection. Early predictors of a preliminary diagnosis of mixed infection were elevated values of fever (AUC = 0.87), intoxication syndrome score (AUC = 0.71), leukocyte count (AUC = 0.64) and neutrophils (AUC = 0.71) in the hemogram, levels of leukocyte intoxication index according to V.K. Ostrovsky (AUC = 0.67) and neutrophil-leukocyte index (AUC = 0.65), as well as a decrease in the number of platelets (AUC = 0.77), eosinophils (AUC = 0.72) and basophils (AUC = 0.79) in peripheral blood. Two prognostic models which included clinical and laboratory parameters demonstrated excellent prediction of mixed infection (AUC = 0.90 and AUC = 0.91).Conclusion. Early clinical and laboratory predictors have been established and models have been developed that make it possible, with excellent prognosis quality, to calculate in patients the probability of a preliminary diagnosis of mixed infection of the erythema form of ixodic tick-borne borreliosis with tick-borne encephalitis in comparison with borreliosis monoinfection.
Кузбасс: возможности инновационно-инвестиционного роста
Authors: Фридман Ю.А. , Речко Г.Н. , Логинова Е.Ю. 
Published: June 2024

Несмотря на официально провозглашенную и закрепленную в документах стратегического планирования Кемеровской области – Кузбасса нацеленность на инновационно-инвестиционный путь развития, у региона до сих пор нет общепризнанной концепции такого развития, а сложившаяся структура экономики не способствует инновационному росту. Представленные в статье результаты анализа воспроизводственной структуры экономики Кузбасса показывают, что инновационно-инвестиционный блок отраслей на протяжении последних полутора десятков лет здесь практически не развивался, и многие необходимые его элементы отсутствуют. Ставка на передовые западные технологии, что активно практиковал регион в конце 1990-х – начале 2000-х гг., в настоящее время не работает. Кемеровской области в обозримой перспективе предстоит выработать новую модель инновационно-инвестиционного роста, которая будет нацелена на адаптацию к новым вызовам, и опираться на ограниченный научно-технологический и инвестиционный потенциал. Одним из наиболее вероятных мегапроектов такой модели развития для региона может стать глубокая переработка угля.
PROGRAM PELATIHAN DETEKSI DINI DAN STIMULASI TUMBUH KEMBANG PADA ORANG TUA SERTA GURU ANAK USIA 3-6 TAHUN DI TK DHARMA WANITA DUKUH 2 KECAMATAN NGADILUWIH
Authors: Wulaningtyas Eko Sri , Yanti Entin Srihadi , Dari Puspo , Alsabah M. Akbar Husein , Puspitasari Oktavia , Fauziah Asmaul , Rahmadini Siska Nuriya , Bale Emerensiana 
Published: June 2024

Kegiatan Pengabdian kepada Masyarakat (PKM) berupa â€œProgram Pelatihan Deteksi Dini Dan Stimulasi Tumbuh Kembang Pada Orang tua serta guru Anak Usia 3-6 Tahun Di TK Dharma Wanita Dukuh 2 Kecamatan Ngadiluwihâ€. Program ini dilatarbelakangi indikator SDGâ€™s 4.2.1 yaitu anak usia dibawah 5 tahun yang berkembang dengan baik (on the track) dalam bidang Kesehatan, pembelajaran dan psikososial (BPS, 2018). Populasi anak Indonesia mencapai 31,56 % dari total seluruh penduduk, yaitu 84.4 juta anak (Kemen PPPA, 2020). Terdapat lebih dari 200 juta anak balita di seluruh dunia diperkirakan mengalami gangguan perkembangan kognitif dan sosial emosional (Zhang J et al, 2018). Anak menjadi modal kemajuan bangsa yang perlu mendapat jaminan pertumbuhan dan perkembangan yang optimal (BPS, 2018). Setiap orang tua mengharapkan tumbuh kembang optimal bagi anak mereka, sayangnya hal ini tidak diiringi pengetahuan dan kemampuan yang optimal dan deteksi dini serta stimulasi tumbuh kembang anak. Penelitian menunjukkan adanya hubungan antara pengetahuan ibu terhadap perkembangan motorik anak usia balita di TK Dharma Wanita Desa Ringinsari Kediri (Eko Sri, 2022).Â Tujuan kegiatan PKM yaitu 1) menjadi program percontohan dalam optimalisasi tumbuh kembang anak usia 3-6 tahun; 2) meningkatkan pengetahuan dan kemampuan orang tua dan guru yang memiliki/mengajar anak usia 3-6 tahun untuk dapat melakukan deteksi dini dan simulasi tumbuh kembang secara mandiri dan berkesinambungan. Target luaran yang ingin dicapai yaitu publikasi artikel pada jurnal ber ISSN (luaran wajib) serta modul aplikatif. Metode yang digunakan berupa penyuluhan, demo, pelatihan dan monitoring pasca kegiatan. Kegiatan PKM berlangsung selama 6 bulan (Agustus sampai Januari 2022).
PENYULUHAN BAHAYA SEDENTARY LIFESTYLE PADA MAHASISWA FAKULTAS ILMU KESEHATAN UNIVERSITAS KADIRI
Authors: Etika Arif Nurma , Agnes Yeni Lufiana Novita , Sulistyawati Wiwin , Suharto Idola Perdana Sulistyoning , Jayani Indah , Susmiati Susmiati , Nurseskasatmata Satria Eureka , Ramayanti Eva Dwi , Lutfi Erik Irham , Yunalia Endang Mei 
Published: June 2024

A Sedentary lifestyle is a low energy expenditure, which expends calories 1.5 METs or less. It most likely leads to various metabolic diseases, such as Diabetic Mellitus. Some factors influencing a sedentary lifestyle are knowledge, attitudes, gender, convenience, transportation, technological advances, COVID-19 outbreaks, and consequences. A sedentary behavior becomes a typical lifestyle among teenagers, including students. Therefore, counseling about a sedentary lifestyle and its effects is very much needed among students. This counseling aims to increase knowledge about the sedentary lifestyle and its dangers so that students can avoid it and increase physical activity. The implementation method in this counseling consists of 3 stages, these stages are preparation, implementation and evaluation. Sixty-five nursing students attended this counseling activity; most participants (70%) were female. The result shows that some respondents did not know about the sedentary lifestyle and its dangers. After counseling, almost all respondents knew about the sedentary lifestyle and its risks. Moreover, they were committed to reducing sedentary behavior and increasing physical activity. Based on the results, it can be concluded that counseling may increase students’ commitment to physical activity and sports.

Keywords: physical activity, Sedentary lifestyle
Possibilities of using the tetraploid interspecific hybrid <i>Hordeum bulbosum</i> L. × <i>Hordeum vulgare</i> L. in obtaining new recombinant barley lines
Authors: Pendinen G. I. , Chernov V. E. , Scholz M. 
Published: June 2024

Background. Hordeum bulbosum L. is the only wild species of the genus Hordeum, the gene pool of which is successfully used in introgressive hybridization to increase the genetic diversity of H. vulgare L. When creating introgression forms based on hybrids of H. vulgare with H. bulbosum, it is necessary to take into consideration the ploidy of the parent species, and their genetic features that determine the intensity of the process of H. bulbosum chromosomes elimination in embryogenesis. The purpose of our investigation was to study the features associated with the elimination of bulbous barley chromosomes in embryos obtained in various combinations of crosses involving the tetraploid hybrid H. bulbosum with H. vulgare for its effective use in obtaining introgression lines of H. vulgare. Material and methods. The analysis was performed on 9-15 days old embryos obtained in crosses of the tetraploid hybrid F2 (H. bulbosum A17 (4x) × H. vulgare ‘Borwina’ (4x)) (HbHbHvHv) with ‘Igri’ (2x) and ‘Borwina’ (2x) barley varieties, with H. bulbosum A17 (4x), as well as during its self-pollination. The chromosomal composition of embryos of different ages was analyzed on squashed embryo slides using genomic in situ hybridization (GISH). Results. Among the 11-15 days old embryos obtained from self-pollination of the hybrid, approximately half of the studied ones were mixoploids, while in other embryos the majority of cells contained only the genomic material of H. vulgare. The elimination process was very intensive in crosses of the hybrid with the barley varieties ‘Igri’ (2x) and ‘Borwina’ (2x), and by day 10-11 after pollination cells containing only the genomic material of H. vulgare predominated in all embryos, regardless of the direction of crossing and the variety used. Hybrid embryos with a stable chromosomal composition resulted from a cross of a tetraploid hybrid with H. bulbosum A17 (4x). Embryos with recombinant H. vulgare chromosomes carrying alien genetic material of bulbous barley were identified in all types of crosses. Conclusion. The most efficient way for the mass production of introgression lines of cultivated barley varieties based on the partially fertile hybrid F2 (H. bulbosum A17 (4x) × H. vulgare ‘Borwina’ (4x)), is the crossing with varieties of H. vulgare (2x). The progeny from such crosses will contain only cultivated barley plants, among which it is possible to identify forms with the introgression of H. bulbosum and use already the first generation from their self-pollination for selecting H. vulgare lines carrying the genetic material of bulbous barley in both homologs.
On the anniversary of the breeder Grigory Fedorovich Monakhos
Authors: Kurkiev K. U. , Monakhos S. G. , Khlestkina E. K. 
Published: June 2024

On March 20, 2024, an outstanding Russian breeder Grigory Fedorovich Monakhos, Head of a scientific school in the field of vegetable breeding, turned 70 years old. The labor, scientific and pedagogical activities of Grigory Fedorovich for more than forty years have been associated with «Timiryazevka” – the Russian State Agrarian University – Moscow Timiryazev Agricultural Academy. Grigory Fedorovich is the author/ co-author of more than 70 hybrids of vegetable crops, of which more than 40 are of white cabbage. In his breeding work, G.F. Monakhos paid the greatest attention to the most complex aspects: the genetic resistance of plants to phytopathogens and pests. Under his leadership, 18 candidates of science defended their theses. G.F. Monakhos is a co-author of more than 130 publications, including a textbook and educational manuals. Grigory Fedorovich is a member of the editorial boards of scientific journals “Izvestiya of Timiryazev Agricultural Academy” and “Potato and Vegetables”.
Il "Ciclo del Cossovo" di Milan Rakić
Authors: Perillo Francesco S. 
Published: June 2024

The essay examines one of the central themes of the work of Milan Rakić, one of the greatest exponents of Serbian Modernism: the cycle of compositions that focus on the history and current affairs of that region, which has always been disputed by Serbs and Albanians. These poems arise from Rakić’s personal experience in Kosovo, still subject to the Ottoman Empire, where he had been sent at the beginning of his diplomatic career. Of the seven poems in the cycle, five sing about the tragic destiny of that land, the cradle of Serbian religiosity; one, Na Gazi Mestanu, associates the taste for historical reenactments of Parnassi’s poetics with the passionate defense and proud exaltation of the Serbian people who in centuries-old relations with their homeland have drawn the stimulus for rebirth; the last, Legacy, the most evocative and vibrant, raises that indissoluble bond with the spiritual richness of the past as a reason for existential comfort. What the love of a woman had not been able to give to the poet is offered to him by the rediscovered communion with the historical consciousness of his own race.