bluuebunny/crossref_metadata_2025_split huggingface dataset:
Combining multivariate statistical analysis to characterize changes in amino acids and volatiles during growth of Lou onion pseudostems
Authors: Hou Xiaojian , Wang Jianglong , Zhang Guangdi , Wang Yu , Wang Ting 
Published: June 2024

AbstractBACKGROUNDThe main edible part of the Lou onion is the pseudostem, which is highly valued for its distinctive flavour. However, harvesting decisions for the pseudostem are often based on size and market price, with little consideration given to flavour. By clarifying the growth of flavour in pseudostems, farmers and consumers may benefit from evidence‐based insights that help optimize harvesting time and maximize flavour quality.RESULTSThis study employed amino acid analysis and gas chromatography–ion migration spectroscopy (GC–IMS) to elucidate the compounds of the pseudostem across different growth phases, and 17 amino acids and 61 volatile substances. Subsequently, analysis revealed that 18 compounds, including arginine (Arg), aspartic acid (Asp), glutamic acid (Glu), valine (Val), (E)‐2‐nonenal, decanal, 2,4‐nonadienal, 2‐octenal, (Z)‐4‐decenal, 2,4‐decadienal benzeneacetaldehyde, linalool, eugenol, (Z)‐6‐nonen‐1‐ol, methyl anthranilate, 2‐acetylpyridine, 3‐sec‐butyl‐2‐methoxypyrazine, and 2,6‐dichlorophenol, were the key compounds in determining the flavour characteristics of the pseudostems, as assessed by taste activity value and relative odour activity value calculations. In addition, correlation analysis, focusing on five amino acids and 38 volatile compounds with variable importance for predictive components scores of >1, identified anisaldehyde, eugenol, (Z)‐6‐nonen‐1‐ol, 2,4‐decadienal, 3‐sec‐butyl‐2‐methoxypyrazine, Arg, Asp, and Val as the key differentiators and contributors to the pseudostems flavour profile.CONCLUSIONDuring the rapid growth of Lou onions just before the emergence of flower stems, the pseudostem exhibited the most prominent flavour, making this stage most suitable for harvesting compared to the regreening growth stage and the rapid growth period of the aerial bulbs. © 2024 Society of Chemical Industry.
Isolation of a surfactin‐producing strain of Bacillus subtilis and evaluation of the probiotic potential and antioxidant activity of surfactin from fermented soybean meal
Authors: Dai Chunhua , Shu Zhenzhen , Ma Chunfang , Yan Pengfei , Huang Liurong , He Ronghai , Ma Haile 
Published: June 2024

AbstractBACKGROUNDSurfactin, usually produced by microbial metabolism, has many advantages including low toxicity, high biodegradability, and stability at extreme pH levels and temperatures, making it suitable for industry. However, its commercial production has not yet been achieved.RESULTSA strain with a strong surfactin‐producing ability was isolated and identified as Bacillus subtilis SOPC5, based on the appearance of colonies, microscopic observation, and 16S rDNA sequencing. The isolate exhibited significant tolerance to acid, bile, gastric, and intestinal juices, and was sufficiently susceptible to antibiotics. Bacillus subtilis SOPC5 showed high levels of auto‐aggregation and surface hydrophobicity, and a strong capacity to secrete protease, amylase, and cellulase. The strain also exhibited antibacterial activity against Staphylococcus aureus 10 306 with a antibacterial circle diameter of 18.0 ± 1.1 mm. The maximal yield of surfactin (1.32 mg mL−1) was obtained by fermenting soybean meal (SBM) using the isolate under the following conditions: SBM 86 g L−1, inoculation 1.5 × 107 CFU mL−1, FeSO4 1.2 mg L−1, MnSO4 2.6 mg L−1, MgSO4 0.5 mg mL−1, L‐Glu 4 mg L−1, temperature 33 °C, duration 120 h, and shaking at 210 rpm. The purity of surfactin was 97.42% as measured by high‐performance liquid chromatography (HPLC). The half inhibitory concentration (IC50) values for surfactin to scavenge 1,1‐diphenyl‐2‐picrylhydrazyl (DPPH) and 2,2‐azino‐bis‐(3‐ethylbenzothiazoline‐6‐sulfonic acid) radical cation (ABTS·+) were 1.275 ± 0.11 and 0.73 ± 0.08 mg mL−1, respectively.CONCLUSIONThis study provides a scientific basis for the application of B. subtilis SOPC5 (as a potential probiotic) and the preparation of its metabolic product (surfactin). © 2024 Society of Chemical Industry.
Evaluation of a Novel Dermal Cooling System for the Treatment of Benign Pigmented Lesions in Asians
Authors: Wong Christina S. M. , Chan Mandy W. M. , Shek Samantha Y. N. , Yeung Chi Keung , Chan Henry H. L. 
Published: June 2024

ABSTRACTObjectiveOur study aimed to evaluate the efficacy of this novel dermal cooling system (DCS) in reducing pigmentation in benign pigmented lesions in Asian patients and its potential side effects.MethodsIt was a prospective open‐label single‐center study. Asian patients, with the presence of benign pigmented lesions mainly including lentigines, melasma, nevus spilus, ephelides, café au lait, and seborrheic keratosis were recruited for a novel DCS. The DCS provided localized cooling of the epidermal layer below freezing but was less intense than cryotherapy. Each patient received DCS at Week 0 and repeated at 4‐week intervals up to 10 sessions. Global aesthetic improvement scores (GAIS) by blinded physicians and subjects were recorded at 2, 6, and 12 months posttreatment follow‐up.ResultsEighty‐one patients were recruited with a total of 305 sessions performed and 1716 lesion sites treated. At 2‐month posttreatment, 76.5% and 58.6% treatment sites showed obvious to marked improvement respectively and the improvement sustained at 6 and 12 months. Only minor adverse events were reported. Erythema and edema were the most commonly anticipated effects immediately after treatment. The pain was minimal. Postinflammatory hyperpigmentation was only reported in 2.2% (38/1716) treated sites.ConclusionTo our knowledge, this study was the first study to demonstrate that this novel DCS was an effective, safe, and well‐tolerated treatment for benign pigmented lesions in Asians.
Presents with presence: The role of memory and essence in heirloom gift appreciation
Authors: Tezer Ali , Philp Matthew , Pancer Ethan , Zhu Queenie 
Published: June 2024

AbstractChoosing the right gift is a common challenge. Despite recent research suggesting that sentimental gifts are most appreciated, it remains unclear of the underlying value of such gifts. The current research examines sentimental gifts in the context of heirlooms and demonstrates that the value of such sentimental gifts comes from their memory value (being a reminder of loved ones) and essence value (being a receptacle of their spiritual presence). These findings emphasize the importance of prior physical contact with an item on the appreciation of heirloom gifts and demonstrates how ordinary store‐bought gifts can benefit from increased appreciation when framed as future heirlooms (being gifted with the intention to be 1 day gifted to future generations). Three experiments find support for these predictions. This research contributes to the understanding of gifting by exploring the mechanisms underlying heirloom gift appreciation and offers guidance to those looking to give gifts that will be well received.
A Water Polysaccharide–Protein Complex from Grifola frondosa Inhibit the Growth of Subcutaneous but Not Peritoneal Colon Tumor under Fasting Condition
Authors: Xu Yongzhao , Huang Chujun , Xu Tianxiong , Xiang Xiong , Amakye William Kwame , Zhao Zikuan , Yao Maojin , Zhu Ying , Ren Jiaoyan 
Published: June 2024

ScopeGrifola frondosa has been shown to induce immune modulatory, modulate autophagy, and apoptosis in cancer cells. However, little is known about its potential for managing tumor progression as an adjunct to nutrient restriction.Methods and resultsWater extract produces a G. frondosa polysaccharide–protein complex (G. frondosa PPC) of average molecular weight of 46.48 kDa, with glucose (54.8%) as the main constituent. Under serum‐restricted conditions, G. frondosa PPC can significantly inhibit MC38 colorectal tumor cell migration in vitro. Under alternate‐day fasting condition, G. frondosa PPC can only significantly inhibit the growth of subcutaneous (s.c.) tumor, but is feeble in halting its spread in the intraperitoneal (i.p.) cavity in tumor‐bearing mice. Histopathological examination and Raman imaging show a significant increase in lipid content in the tumor microenvironment (TME) tissue of the s.c. tumor‐bearing mice. G. frondosa PPC significantly increases C17:0 and C24:0 saturated fatty acids and significantly decreases C16:1 and C18:1 monounsaturated fatty acids in the TME of s.c. tumor‐bearing mice compared with the i.p. cavity model.ConclusionG. frondosa PPC significantly inhibits tumor growth in s.c. tumor‐bearing mice under intermittent fasting conditions by altering the fatty acid composition of the TME.
Registered nurses' experiences on job satisfaction in nursing home settings
Authors: Jakobsson Larsson Birgitta , Mannberg Marie , Pöder Ulrika , Hedström Mariann , Karlsson Ann‐Christin 
Published: June 2024

AbstractAimTo describe what registered nurses' experience to be important to job satisfaction in nursing home settings.DesignThis is a qualitative study based on data from individual interviews.MethodsSixteen registered nurses working in nursing homes were interviewed, and their responses were analysed with systematic text condensation.ResultsA total of six categories were developed to describe various aspects of job satisfaction among registered nurses at nursing homes: meaningfulness is essential, to possess control and manageability is central, a possibility to balance daily challenges with professional development, supportive leadership is imperative, the nursing team's competence and companionship, and being confident in one's own profession.ConclusionIn the present study, meaningfulness was essential to job satisfaction, and work was experienced to be meaningful and engaging when the demands were manageable, the workload controllable, and when the registered nurses felt supported by management and co‐workers. Conversely, if the demands were too high, the workload was beyond their control and the nurses felt unsupported, then the work felt meaningless and thus unsatisfactory.
The effect of computation interventions for students with autism spectrum disorder: A meta‐analysis and systematic review
Authors: Liu Di , Mao Yiwen , Lory Catharine , Lei Qingli , Zeng Yingying 
Published: June 2024

AbstractComputation is foundational to learning many mathematics concepts, as well as a functional skill in everyday life. Yet students with autism spectrum disorder (ASD) often have challenges in learning computation skills. The current study aimed to provide quantitative and descriptive analyses of single‐case experimental studies on computation interventions for students with ASD. Our systematic search and screening procedures yielded a total of 16 eligible studies for the final analyses. An analysis of publication bias indicated an absence of publication bias in the included studies. Tau‐U was used to calculate the overall intervention effect, resulting in an omnibus effect of 0.90 (95% CI [0.81, 1.00]), indicating a medium effect. Moderator analyses showed that variables such as study design, participant characteristics, intervention characteristics, and target skills did not moderate intervention effects. However, some evidence‐based practices were identified to significantly moderate maintenance effects. Implications for researchers and practitioners are discussed.
Investigation of thermal damage in explosive bridgewire detonators via discrete element method simulations
Authors: Wolf Ki T. , Clemmer Joel T. , Hobbs Michael L. , Kaneshige Michael , Bolintineanu Dan S. , Brown Judith A. 
Published: June 2024

AbstractExploding bridgewire (EBW) detonators are used to rapidly and reliably initiate energetic reactions by exploding a bridgewire via Joule heating. While the mechanisms of EBW detonators have been studied extensively in nominal conditions, comparatively few studies have addressed thermally damaged detonator operability. We present a mesoscale simulation study of thermal damage in a representative EBW detonator, using discrete element method (DEM) simulations that explicitly account for individual particles in the pressed explosive powder. We use a simplified model of melting, where solid spherical particles undergo uniform shrinking, and fluid dynamics are ignored. The subsequent settling of particles results in the formation of a gap between the solid powder and the bridgewire, which we study under different conditions. In particular, particle cohesion has a significant effect on gap formation and settling behavior, where sufficiently high cohesion leads to coalescence of particles into a free‐standing pellet. This behavior is qualitatively compared to experimental visualization data, and simulations are shown to capture several key changes in pellet shape. We derive a minimum and maximum limit on gap formation during melting using simple geometric arguments. In the absence of cohesion, results agree with the maximum gap size. With increasing cohesion, the gap size decreases, eventually saturating at the minimum limit. We present results for different combinations of interparticle cohesion and detonator orientations with respect to gravity, demonstrating the complex behavior of these systems and the potential for DEM simulations to capture a range of scenarios.
Zosterabisphenone B, a new diarylheptanoid heterodimer from the seagrass Zostera marina, induces apoptosis cell death in colon cancer cells and reduces tumour growth in mice
Authors: Cacciola Nunzio Antonio , De Cicco Paola , Amico Rebecca , Sepe Fabrizia , Li Yan , Grauso Laura , Nanì Maria Francesca , Scarpato Silvia , Zidorn Christian , Mangoni Alfonso , Borrelli Francesca 
Published: June 2024

AbstractColorectal cancer (CRC) is one of the most common malignant tumours worldwide. Diarylheptanoids, secondary metabolites isolated from Zostera marina, are of interest in natural products research due to their biological activities. Zosterabisphenone B (ZBP B) has recently been shown to inhibit the viability of CRC cells. The aim of this study was to investigate the therapeutic potential of ZBP B for targeting human CRC cells. Cell viability was determined using the MTT assay. Flow cytometry and Western blot analyses were used to assess apoptosis and autophagy. A CRC xenograft model was used to evaluate the in vivo effect of ZBP B. No cytotoxic effect on HCEC cells was observed in the in vitro experiments. ZBP B caused morphological changes in HCT116 colon cancer cells due to an increase in early and late apoptotic cell populations. Mechanistically, ZBP B led to an increase in cleaved caspase‐3, caspase‐8, caspase‐9, PARP and BID proteins and a decrease in Bcl‐2 and c‐Myc proteins. In the xenograft model of CRC, ZBP B led to a reduction in tumour growth. These results indicate that ZBP B exerts a selective cytotoxic effect on CRC cells by affecting apoptotic signalling pathways and reducing tumour growth in mice. Taken together, our results suggest that ZBP B could be a lead compound for the synthesis and development of CRC drugs.
A Study Into the Hot Tack and Cooled Seal Performance of Emerging Coated Papers for Primary Flexible Food Packaging
Authors: Bamps Bram , Samyn Pieter , Rosenow Phil , Stobinska Magdalena , Kamola Paulina , Tarnowiecka‐Kuca Alicja , Peeters Roos 
Published: June 2024

ABSTRACTIn response to the need to employ recyclable materials for food packaging, the resurgence of paper as a primary flexible packaging material is driven by consumer trust in paper and its renewable wood fibre composition, strengthened by a well‐established recycling infrastructure. A diverse range of coated papers and coatings has become accessible in the market, specifically tailored for applications in horizontal and vertical form‐fill sealing. Within the framework of the CORNET‐TETRA project HBC.2021.0288 REPAC2, a careful selection of 16 food‐grade coated papers and/or coatings, slated for introduction to the market either presently or within the next 2 years, has been undertaken. This study focused on evaluating the processing window for superior hot tack and cooled seal performance of coated papers, in relation with the composition of paper coatings as identified using Fourier transform infrared (FTIR) measurements, and their thermal softening or melting characteristics as identified through differential scanning calorimetry (DSC). Thermal behaviour in DSC thermograms is used to categorize the commercial coated papers into distinct classes. Class I papers, mainly with acrylic‐based coatings, exhibit high hot tack strengths (0.2–0.7 N/mm) and a glass transition temperature (Tg) close to the seal initiation temperature but do not considerably gain strength with further cooling. Class II papers are thermally inert in DSC with minimal thermoplastics, leading to weak seals. In contrast, classes III and IV, including wax‐based and polyolefin‐based or polyvinylalcohol‐based (PVOH) coatings, respectively, show low initial hot tack strengths that considerably increase upon adequate cooling. Particularly, the Class IV papers with polyolefin‐based coatings have well‐performing seals. Despite having relatively low hot tack strengths after cool times of 0.1 s, below 0.3 N/mm, high strengths can be obtained after adequate cooling with outliers reaching 0.74 and 1.14 N/mm. Additionally, the influences of seal parameters on seal performance were evaluated. The study reveals that cool time, seal pressure and, to a lesser extent, seal time significantly impact hot tack strength, consistent with prior research. The critical role of jaw temperature in heat conductive sealing is affirmed, as it dictates the efficacy of other seal parameters. Seal initiation occurs at 75°C for four papers, and nine others necessitate temperatures equal to or exceeding 100°C, with one paper only displaying seal initiation at 195°C. This variation highlights the requisite for tailored temperature windows for effective sealing of these papers. As such, deeper insights into the intricate interplay between coating composition, thermal properties and seal performance are obtained in order to support advances in sustainable packaging technology.
Exploring charge transfer effects on linear, non‐linear optical, and dye‐sensitized solar cell properties: A DFT and TD‐DFT investigation of carbazole and aniline‐based dyes
Authors: Sharma Suryapratap J. , Sekar Nagaiyan 
Published: June 2024

AbstractThe efficacy of aniline and carbazole‐based sensitizers used in dye‐sensitized solar cells (DSSCs) is correlated with the trends in density functional theory (DFT) based charge transfer (CT) and non‐linear optical (NLO) properties since both DSSC and NLO properties highly rely on CT properties. The aniline‐based donors showed a higher degree of planarity over carbazole‐based donor sensitizers. This improved planarity in aniline‐based sensitizers is attributed to efficient charge transfer and higher dipole moment. The efficient CT within the sensitizers is confirmed with bond‐length alternation (BLA), bond order alternation (BOA), and quinoid character (QC). A direct correlation of band‐gap (EG) with μ, ω, η, and Γ is witnessed. Time‐dependent DFT (TD‐DFT) results of vertical excitation demonstrated similar trends that are observed practically. Indeed, we observed a direct correlation between α and β and the experimentally observed DSSC efficiency. DFT and TD‐DFT methods, linear, employed for computing the CT and linear and DSSC properties as implemented in Gaussian 09. NLO properties were simulated through single‐point polar calculations. B3LYP and PBE1PBE functionals were used for geometry optimization. The linear and NLO properties were determined in various functionals, that is, global hybrid and range‐separated hybrid functionals. A polarizable continuum model (PCM) was used for solvation studies. To understand the realistic picture of the dye@TiO2 cluster, dye bound on TiO2 clusters were optimized using a LANL2DZ basis set specifically for the Ti atom.
Analysis of mutation‐originated gain‐of‐glycosylation using mass spectrometry‐based N‐glycoproteomics
Authors: Yang Hailun , Tian Zhixin 
Published: June 2024

RationaleA general N‐glycoproteomics analysis pipeline has been established for characterization of mutation‐related gain‐of‐glycosylation (GoG) at intact N‐glycopeptide molecular level, generating comprehensive site and structure information of N‐glycosylation.MethodsThis study focused on mutation‐originated GoG using a mass spectrometry‐based N‐glycoproteomics analysis workflow. In brief, GoG intact N‐glycopeptide databases were built, consisting of 2701 proteins (potential GoG N‐glycosites and amino acids derived from MUTAGEN, VARIANT and VAR_SEQ in UniProt) and 6709 human N‐glycans (≤50 sequence isomers per monosaccharide composition). We employed the site‐ and structure‐specific N‐glycoproteomics workflow utilizing intact N‐glycopeptides search engine GPSeeker to identify GoG intact N‐glycopeptides from parental breast cancer stem cells (MCF‐7 CSCs) and adriamycin‐resistant breast cancer stem cells (MCF‐7/ADR CSCs).ResultsWith the criteria of spectrum‐level false discovery rate control of ≤1%, we identified 87 and 94 GoG intact N‐glycopeptides corresponding to 37 and 35 intact N‐glycoproteins from MCF‐7 CSCs and MCF‐7/ADR CSCs, respectively. Micro‐heterogeneity and macro‐heterogeneity of N‐glycosylation from GoG intact N‐glycoproteins with VAR_SEQ and VARIANT were found in both MCF‐7 CSCs and MCF‐7/ADR CSCs systems.ConclusionsThe integration of site‐ and structure‐specific N‐glycoproteomics approach, conjugating with GoG characterization, provides a universal workflow for revealing comprehensive N‐glycosite and N‐glycan structure information of GoG. The analysis of mutation‐originated GoG can be extended to GoG characterization of other N‐glycoproteome systems including complex clinical tissues and body fluids.
Efficient state change detection method for modeling stateful time series data
Authors: Liu Xianmin , Luo Ruixin , Li Wenbo , Bi Qiang 
Published: June 2024

AbstractTime series analysis is an important research area and has wide real applications. Time series modeling has been identified and well known as the key fundamental problem in time series analysis, and it has received lots of research attentions. The hardness of achieving sophisticated and efficient time series models depends on the characteristic of the data met. In practical, time series data are usually generated by the physical process with several working states, which are determined by the system design. In such cases, the data characteristics of each state is quite different from the other states, where the modeling problem becomes much harder and it is more challenging to design modeling methods for stateful time series data. Therefore, this paper focuses on the stateful time series data, and studies the state change detection problem, which is identified as a key fundamental problem for modeling stateful data. To achieve effective and efficient state change detection, the proposed method utilizes two essential ideas. Since the discrepancy (a.k.a. histogram) based method has been proposed and verified to be more effective by previous works, the first idea is to improve its performance by involving more temporal information and utilizing the encoder–decoder techniques to reform the data. In view of the efficiency issue of the discrepancy‐based method, the second idea is to integrate both the Bayesian and discrepancy‐based detection methods, such that a perfect tradeoff between time efficiency and detection performance can be achieved. Experiments on both real and synthetic datasets show that the proposed methods are both effective and efficient, and the state change detection problem can be solved well by them on stateful time series data.