bluuebunny/crossref_metadata_2025_split huggingface dataset:
COVID-19 in three waves in a tertiary referral hospital in Belgium: a comparison of patient characteristics, management, and outcome
Authors: De Paepe Andreas , Vlieghe Erika , Brusselaers Nele , Soentjens Patrick , Theunissen Caroline , Brosius Isabel , Grouwels Jeroen , Van Petersen Lida , van Tiggelen Hanne , Verbrugghe Walter , Jorens Philippe G , Lapperre Thérèse , Peeters Karen , Vermeulen Griet , van Ierssel Sabrina H 
Published: May 2024

Abstract
Purpose
Few studies have compared patient characteristics, clinical management, and outcome of patients with COVID-19 between the different epidemic waves. In this study, we describe patient characteristics, treatment, and outcome of patients admitted for COVID-19 in the Antwerp University Hospital over the first three epidemic waves of 2020–2021.

Methods
Retrospective observational study of COVID-19 patients in a Belgian tertiary referral hospital. All adult patients with COVID-19, hospitalized between February 29, 2020, and June 30, 2021, were included. Standardized routine medical data was collected from patient records. Risk factors were assessed with multivariable logistic regression.

Results
We included 722 patients, during the first (n = 179), second (n = 347) and third (n = 194) wave. We observed the lowest disease severity at admission during the first wave, and more elderly and comorbid patients during the second wave. Throughout the subsequent waves we observed an increasing use of corticosteroids and high-flow oxygen therapy. In spite of increasing number of complications throughout the subsequent waves, mortality decreased each wave (16.6%,15.6% 11.9% in 1st, 2nd and 3rd wave respectively). C-reactive protein above 150 mg/L was predictive for the need for intensive care unit admission (odds ratio (OR) 3.77, 95% confidence interval (CI) 2.32–6.15). A Charlson comorbidity index ≥ 5 (OR 5.68, 95% CI 2.54–12.70) and interhospital transfers (OR 3.78, 95% CI 2.05–6.98) were associated with a higher mortality.

Conclusions
We observed a reduction in mortality each wave, despite increasing comorbidity. Evolutions in patient management such as high-flow oxygen therapy on regular wards and corticosteroid use may explain this favorable evolution.
Harvesting nature's bounty: exploring the ethnobotanical landscape of wild edible plants in the Awi Agäw community, Northwestern Ethiopia
Authors: Fassil Amare , Mazengia Ethiopia , Gebreamanuel Bekele , Dessie Yitayih , Kumera Bulti , Atnkut Belsti , Mullualem Destaw , Tsega Alemu , Van Damme Patrick 
Published: May 2024

Abstract
Background
Feeding the world's future population while still facing a variety of socioeconomic and climate change scenarios with uncertain outcomes is a key global societal concern that should be addressed in a science-based manner. Ethiopia boasts a great diversity of wild edible plant species (WEPS), but millions of its citizens still suffer from chronic hunger every year. In this context, we here document the use and conservation of WEPS in the Awi Agäw community, Northwestern Ethiopia.

Methods
We performed a cross-sectional study from October 2021 to June 2022. Ethnobotanical and conservation status data were collected via semi-structured interviews, focus group discussions, field walks and market surveys. A total of 374 respondents from three districts (Guangua, Jawi and Ankasha) were purposely selected for the study. Descriptive statistics, including preference rankings, frequencies and direct matrix rankings, were employed for the data analysis.

Results
We identified a total of 39 WEPS plant taxa distributed among 26 families and 32 genera. The Moraceae and Rosaceae had the greatest numbers of plants, with five and three species, respectively. The WEPS are regularly consumed in the study area to alleviate hunger. However, threats such as habitat loss, agricultural expansion, deforestation for firewood and other reasons, and pesticide use threaten WEPS availability.

Conclusion
Therefore, community-based conservation interventions need to be encouraged to safeguard WEPS and associated traditional knowledge. Furthermore, nutritional quality analysis is recommended for the selection of promising WEPS candidates.
The incidence of and risk factors for radiation pneumonitis in patients treated with simultaneous bevacizumab and thoracic radiotherapy
Authors: Chen Feihu , Niu Jiling , Wang Min , Zhu Hui , Guo Zhijun 
Published: May 2024

Abstract
Background
First-line chemotherapy combined with bevacizumab is one of the standard treatment modes for patients with advanced non-small cell lung cancer (NSCLC). Thoracic radiotherapy (TRT) can provide significant local control and survival benefits to patients during the treatment of advanced NSCLC. However, the safety of adding TRT has always been controversial, especially because of the occurrence of radiation pneumonia (RP) during bevacizumab treatment. Therefore, in this study, we used an expanded sample size to evaluate the incidence of RP when using bevacizumab in combination with TRT.

Patients and methods
Using an institutional query system, all medical records of patients with NSCLC who received TRT during first-line chemotherapy combined with bevacizumab from 2017 to 2020 at Shandong Cancer Hospital and Institute were reviewed. RP was diagnosed via computed tomography and was classified according to the RTOG toxicity scoring system. The risk factors for RP were identified using univariate and multivariate analyses. The Kaplan–Meier method was used to calculate progression-free survival (PFS) and overall survival (OS).

Results
Ultimately, 119 patients were included. Thirty-eight (31.9%) patients developed Grade ≥ 2 RP, of whom 27 (68.1%) had Grade 2 RP and 11 (9.2%) had Grade 3 RP. No patients developed Grade 4 or 5 RP. The median time for RP occurrence was 2.7 months (range 1.2–5.4 months). In univariate analysis, male, age, KPS score, V20 > 16.9%, V5 > 33.6%, PTV (planning target volume)-dose > 57.2 Gy, and PTV-volume > 183.85 cm3 were correlated with the occurrence of RP. In multivariate analysis, male, V20 > 16.9%, and PTV-volume > 183.85 cm3 were identified as independent predictors of RP occurrence. The mPFS of all patients was 14.27 (95% CI, 13.1–16.1) months. The one-year and two-year PFS rates were 64.9% and 20.1%, respectively. The mOS of all patients was 37.09 (95% CI, 33.8–42.0) months. The one-year survival rate of all patients was 95%, and the two-year survival rate was 71.4%.

Conclusions
The incidence of Grade ≥ 2 RP in NSCLC patients who received both bevacizumab and TRT was 31.9%. Restricting factors such as V20 and PTV will help reduce the risk of RP in these patients. For patients who receive both bevacizumab and TRT, caution should be exercised when increasing TRT, and treatment strategies should be optimized to reduce the incidence of RP.
Structural and viscosity studies of dendritic hyper branched polymer as viscosity index improvers
Authors: El-shazly Reham I. , Kamal Rasha S. , Farag Reem K. 
Published: May 2024

AbstractStar-like structural compounds were synthesized from different moles % of either dodecyl acrylate or triethylenetetramine using a one-pot commercial synthesis technique. The polymers that were created had various terminations. Fourier Transform Infrared (FTIR) spectroscopy and 1HNMR were used to verify the produced polymers' chemical composition with different terminations. Furthermore, by analysis of Dynamic Light Scattering (DLS), the size and distribution of the synthesised branched polymers were evaluated. Using a Gel-permeation chromatograph, the modified hyperbranched polymer's molecular weight, synthesized with various end points, were assessed. The unorganized structured prepared compounds with various molar feed ratios dodecyl acrylate: triethylenetetramine (DDA: TETA) was designed as A, B, C, D and E. Moreover, the synthesized additives function as viscosity index improvers (VII). As the concentration of polymeric additives increases, it leads to higher VI values. Similarly, with the increase in percentage of triethylenetetramine in the prepared hyperbranched polymers, the VI also increases. Notably, the most effective VI achieved is (E) = 212. It is noteworthy that all the synthesized hyperbranched polymers exhibited Newtonian behavior in the rheological study.
Learning-based light field imaging: an overview
Authors: Mahmoudpour Saeed , Pagliari Carla , Schelkens Peter 
Published: May 2024

AbstractConventional photography can only provide a two-dimensional image of the scene, whereas emerging imaging modalities such as light field enable the representation of higher dimensional visual information by capturing light rays from different directions. Light fields provide immersive experiences, a sense of presence in the scene, and can enhance different vision tasks. Hence, research into light field processing methods has become increasingly popular. It does, however, come at the cost of higher data volume and computational complexity. With the growing deployment of machine-learning and deep architectures in image processing applications, a paradigm shift toward learning-based approaches has also been observed in the design of light field processing methods. Various learning-based approaches are developed to process the high volume of light field data efficiently for different vision tasks while improving performance. Taking into account the diversity of light field vision tasks and the deployed learning-based frameworks, it is necessary to survey the scattered learning-based works in the domain to gain insight into the current trends and challenges. This paper aims to review the existing learning-based solutions for light field imaging and to summarize the most promising frameworks. Moreover, evaluation methods and available light field datasets are highlighted. Lastly, the review concludes with a brief outlook for future research directions.
Akkermansia muciniphila postbiotic administration mitigates choline-induced plasma Trimethylamine-N-Oxide production in mice
Authors: Xu Hongjuan , Bian Xiaoyun , Wang Hongxing , Huang Lin , Chen Xiaoxi 
Published: May 2024

Abstract
Background
Trimethylamine-N-Oxide (TMAO) is believed to be linked to increased likelihood of cardiovascular disease. While probiotics have shown limited effectiveness in reducing TMAO levels, the potential of postbiotics remains underexplored. This study aimed to evaluate the impact of Akkermansia muciniphila (A. muciniphila) postbiotic administration on choline-induced TMAO production in mice by modifying the gut microbiota.

Methods
Female C57BL/6J mice were divided into six groups, including a control group, high-choline diet group, live A. muciniphila probiotic group, pasteurized A. muciniphila postbiotic group, sodium butyrate group, and sodium propionate group. Various measurements and analyses were conducted, including TMAO and TMA levels in serum, urine, and cecal contents, as well as the expression of FXR and FMO3 in liver tissues. Additionally, metabolic parameters, body weight, serum lipid profile, hepatic protein expression (FMO3, FXR, CutC, and CutD), and gut microbiota composition were assessed.

Results
Administration of A. muciniphila postbiotic significantly reduced choline-induced plasma TMAO levels in mice. Furthermore, improvements in serum lipid profiles and liver enzyme levels suggested potential enhancements in lipid metabolism and liver function. The study also observed modulation of specific proteins related to TMAO production and metabolism, including CutC and CutD.

Conclusion
The findings highlight the potential of A. muciniphila postbiotics as a dietary strategy for mitigating cardiovascular disease risk by modulating the gut-TMAO axis. Postbiotics, particularly A. muciniphila, offer advantages over probiotics and warrant further investigation for their therapeutic applications in gastrointestinal and metabolic disorders.

Graphical Abstract
The effectiveness of interventions for offending behaviours in adults with autism spectrum disorders (ASD): a systematic PRISMA review
Authors: Salter Jody , Blainey Sarah 
Published: May 2024

AbstractPrevious research has suggested that the core features of autism spectrum disorders (ASD) may contribute to offending behaviours and increased vulnerability within the Criminal Justice System. To date, there is a paucity of evidence assessing the effectiveness of interventions for offending behaviour in adults with ASD but without co-occurring intellectual disability (ID) across a broad range of forensic settings. The lack of robust evidence is concerning, as limited effectiveness may contribute to an increased likelihood of prolonged incarceration, particularly in the most restrictive settings. A PRISMA systematic review was conducted with a narrative synthesis to: (a) evaluate the evidence of the effectiveness of interventions aimed at reducing recidivism, (b) assess whether the core features of ASD impact the effectiveness of these interventions, and (c) identify additional factors that may affect the effectiveness of interventions within this population. Seven studies involving ten male participants were identified. The findings suggest that interventions for offending behaviours in adults with ASD without intellectual disability (ID) are largely inadequate, and that core ASD features need to be considered. Additionally, a complex interplay of risk factors potentially impacting intervention effectiveness was suggested. Limitations include heterogeneity across intervention types, measures of effectiveness, and what constitutes effectiveness. Despite the limited number of studies and data quality, the review aligns with a growing body of literature highlighting vulnerability and a need for evidence-based interventions for people with ASD. The review also discusses the broader implications of ineffective interventions.
Energy supply during nocturnal endurance flight of migrant birds: effect of energy stores and flight behaviour
Authors: Jenni-Eiermann Susanne , Liechti Felix , Briedis Martins , Rime Yann , Jenni Lukas 
Published: May 2024

Abstract
Background
Migrating birds fly non-stop for hours or even for days. They rely mainly on fat as fuel complemented by a certain amount of protein. Studies on homing pigeons and birds flying in a wind-tunnel suggest that the shares of fat and protein on total energy expenditure vary with flight duration and body fat stores. Also, flight behaviour, such as descending flight, is expected to affect metabolism. However, studies on free flying migrant birds under natural conditions are lacking.

Methods
On a Swiss Alpine pass, we caught three species of nocturnal migrant passerines out of their natural migratory flight. Since most night migrants start soon after dusk, we used time since dusk as a measure of flight duration. We used plasma concentrations of metabolites of the fat, protein, and carbohydrate metabolism as indicators of relative fuel use. We used flight altitudes of birds tracked with radar and with atmospheric pressure loggers to characterize flight behaviour.

Results
The indicators of fat catabolism (triglycerides, very low-density lipoproteins, glycerol) were positively correlated with body energy stores, supporting earlier findings that birds with high fat stores have a higher fat catabolism. As expected, plasma levels of triglycerides, very low-density lipoproteins, glycerol and ß-hydroxy-butyrate increased at the beginning of the night, indicating that nocturnal migrants increased their fat metabolism directly after take-off. Surprisingly, fat catabolism as well as glucose levels decreased in the second half of the night. Data from radar observations showed that the number of birds aloft, their mean height above ground and vertical flight speed decreased after midnight. Together with the findings from atmospheric pressure-loggers put on three species, this shows that nocturnal migrants migrating over continental Europe descend slowly during about 1.5 h before final landfall at night, which results in 11–30% energy savings according to current flight models.

Conclusions
We suggest that this slow descent reduces energy demands to an extent which is noticeable in the plasma concentration of lipid, protein, and carbohydrate metabolites. The slow descent may facilitate the search for a suitable resting habitat and serve to refill glycogen stores needed for foraging and predator escape when landed.
Undergraduates’ reactions to errors mediates the association between growth mindset and study strategies
Authors: Chouvalova Anastasia , Navlekar Anisha S. , Mills Devin J. , Adams Mikayla , Daye Sami , De Anda Fatima , Limeri Lisa B. 
Published: May 2024

Abstract
Background
Students employ a variety of study strategies to learn and master content in their courses. Strategies vary widely in their effectiveness for promoting deep, long-term learning, yet most students use ineffective strategies frequently. Efforts to educate students about effective study strategies have revealed that knowledge about effective strategies is by itself insufficient for encouraging widespread and lasting changes. An important next step is to uncover factors that influence the decisions students make about study strategy use. We explored the association between beliefs about intelligence (mindset, universality, and brilliance) and study strategies. The most effective study strategies are error-prone, and beliefs about intelligence carry implications for whether errors are a normal and even beneficial part of the learning process (e.g., growth mindset) or signs of insufficient intelligence (e.g., fixed mindset). Therefore, we hypothesized that beliefs about and reactions to errors would mediate a relationship between beliefs about intelligence and study strategies. We tested this hypothesis by surveying 345 undergraduates enrolled in an introductory biology class at a public, research-active university in northwestern United States.

Results
Confirmatory factor analysis indicated that the internal structure of all measures functioned as expected in our sample. We fit a structural equation model to evaluate our hypothesized model. We found that mindset, but not universality nor brilliance, predicts variance in both beliefs about errors and reactions to errors. In turn, adaptive reactions to errors (but not beliefs about errors) are associated with the use of highly effective study strategies and spacing study sessions. There was a significant indirect relationship between growth mindset and spacing of study sessions.

Conclusions
Our results provide evidence for a mechanism explaining the association between students’ mindset beliefs and academic outcomes: believing that intelligence is improvable is associated with more adaptive reactions to making errors, which correlates with choosing more error-prone and therefore more effective study strategies. Future interventions aimed at improving students’ study strategies may be more effective if they simultaneously target reacting adaptively to errors and emphasize that intelligence is improvable.
Comparative Effectiveness of Different Exercises for Reducing Pain Intensity in Primary Dysmenorrhea: A Systematic Review and Network Meta-analysis of Randomized Controlled Trials
Authors: Tsai I-Chen , Hsu Chih-Wei , Chang Chun-Hung , Lei Wei-Te , Tseng Ping-Tao , Chang Ke-Vin 
Published: May 2024

Abstract
Background
Studies have demonstrated that exercise can mitigate the intensity of menstrual pain in primary dysmenorrhea, but the most effective type of exercise remains unclear. The objective of this systematic review and network meta-analysis was to evaluate the effectiveness of different exercise regimens in reducing pain associated with primary dysmenorrhoea.

Methods
Randomized controlled trials investigating the relationship between menstrual pain and exercise were selected from major electronic databases until February 2, 2024. The primary outcome was the effect of exercise on pain intensity measured by the mean difference on a 10-cm visual analogue scale at 4 and 8 weeks after intervention. The secondary outcome was the difference in risk of dropout at 8 weeks. The study protocol was registered as INPLASY202330050.

Results
This systematic review and network meta-analysis included 29 randomized controlled trials, which involved 1808 participants with primary dysmenorrhea. Exercise interventions included relaxation exercise, strength training, aerobic activity, yoga, mixed exercise, and the Kegel maneuver. Relaxation exercise was the most effective in reducing menstrual pain in 4 weeks (− 3.56; 95% confidence interval: − 5.03 to − 2.08). All exercise interventions were effective in reducing menstrual pain at 8 weeks, with reductions ranging from − 3.87 (95% CI − 5.51 to − 2.22) for relaxation exercise to − 2.75 (95% CI − 4.00 to − 1.51) for yoga, compared to the control group. Relaxation exercises were found to have a significantly lower dropout risk (− 0.11; 95% CI  − 0.20 to 0.02), while none of the exercise types was associated with a higher dropout risk than the control group.

Conclusion
All exercise interventions were effective in reducing menstrual pain in primary dysmenorrhea after 8 weeks of intervention. However, relaxation exercise was found to be the most effective intervention at 4 and 8 weeks and had the lowest risk of dropout.

Graphical Abstract
Developing a production workflow for 3D-printed temporal bone surgical simulators
Authors: Ang Andre Jing Yuen , Chee Shu Ping , Tang Joyce Zhi En , Chan Ching Yee , Tan Vanessa Yee Jueen , Lee Jordan Adele , Schrepfer Thomas , Ahamed Noor Mohamed Nisar , Tan Mark Bangwei 
Published: May 2024

Abstract
Introduction
3D-printed temporal bone models enable the training and rehearsal of complex otological procedures. To date, there has been no consolidation of the literature regarding the developmental process of 3D-printed temporal bone models. A brief review of the current literature shows that many of the key surgical landmarks of the temporal bone are poorly represented in models. This study aims to propose a novel design and production workflow to produce high-fidelity 3D-printed temporal bone models for surgical simulation.

Methods
Developmental phases for data extraction, 3D segmentation and Computer Aided Design (CAD), and fabrication are outlined. The design and fabrication considerations for key anatomical regions, such as the mastoid air cells and course of the facial nerve, are expounded on with the associated strategy and design methods employed. To validate the model, radiological measurements were compared and a senior otolaryngologist performed various surgical procedures on the model.

Results
Measurements between the original scans and scans of the model demonstrate sub-millimetre accuracy of the model. Assessment by the senior otologist found that the model was satisfactory in simulating multiple surgical procedures.

Conclusion
This study offers a systematic method for creating accurate 3D-printed temporal bone models for surgical training. Results show high accuracy and effectiveness in simulating surgical procedures, promising improved training and patient outcomes.
Key derivable signature and its application in blockchain stealth address
Authors: Wang Ruida , Li Ziyi , Lu Xianhui , Zhang Zhenfei , Wang Kunpeng 
Published: May 2024

AbstractStealth address protocol (SAP) is widely used in blockchain to achieve anonymity. In this paper, we formalize a key derivable signature scheme (KDS) to capture the functionality and security requirements of SAP. We then propose a framework to construct key separation KDS, which follows the key separation principle as all existing SAP solutions to avoid the reuse of the master keys in the derivation and signature component. We also study the joint security in KDS and construct a key reusing KDS framework, which implies the first compact stealth address protocol using a single key pair. Finally, we provide instantiations based on the elliptic curve (widely used in cryptocurrencies) and on the lattice (with quantum resistance), respectively.