bluuebunny/crossref_metadata_2025_split huggingface dataset:
Super‐Resolution Imaging of Nanoscale Inhomogeneities in hBN‐Covered and Encapsulated Few‐Layer Graphene
Authors: Jäckering Lina , Wirth Konstantin G. , Conrads Lukas , Profe Jonas B. , Rothstein Alexander , Kyoseva Hristiyana , Watanabe Kenji , Taniguchi Takashi , Kennes Dante M. , Stampfer Christoph , Waldecker Lutz , Taubner Thomas 
Published: February 2025

AbstractEncapsulating few‐layer graphene (FLG) in hexagonal boron nitride (hBN) can cause nanoscale inhomogeneities in the FLG, including changes in stacking domains and topographic defects. Due to the diffraction limit, characterizing these inhomogeneities is challenging. Recently, the visualization of stacking domains in encapsulated four‐layer graphene (4LG) has been demonstrated with phonon polariton (PhP)‐assisted near‐field imaging. However, the underlying coupling mechanism and ability to image subdiffractional‐sized inhomogeneities remain unknown. Here, direct replicas and magnified images of subdiffractional‐sized inhomogeneities in hBN‐covered trilayer graphene (TLG) and encapsulated 4LG, enabled by the hyperlensing effect, are retrieved. This hyperlensing effect is mediated by hBN's hyperbolic PhP that couple to the FLG's plasmon polaritons. Using near‐field microscopy, the coupling is identified by determining the polariton dispersion in hBN‐covered TLG to be stacking‐dependent. This work demonstrates super‐resolution and magnified imaging of inhomogeneities, paving the way for the realization of homogeneous encapsulated FLG transport samples to study correlated physics.
HDAC2‐Mediated METTL3 Delactylation Promotes DNA Damage Repair and Chemotherapy Resistance in Triple‐Negative Breast Cancer
Authors: He Xiaoniu , Li Yuanpei , Li Jian , Li Yu , Chen Sijie , Yan Xia , Xie Zhangrong , Du Jiangfeng , Chen Guoan , Song Jianbo , Mei Qi 
Published: February 2025

AbstractThe current treatment of triple‐negative breast cancer (TNBC) is still primarily based on platinum‐based chemotherapy. However, TNBC cells frequently develop resistance to platinum and experience relapse after drug withdrawal. It is crucial to specifically target and eliminate cisplatin‐tolerant cells after platinum administration. Here, it is reported that upregulated N
6‐methyladenosine (m6A) modification drives the development of resistance in TNBC cells during cisplatin treatment. Mechanistically, histone deacetylase 2 (HDAC2) mediates delactylation of methyltransferase‐like 3 (METTL3), facilitating METTL3 interaction with Wilms’‐tumor‐1‐associated protein and subsequently increasing m6A of transcript‐associated DNA damage repair. This ultimately promotes cell survival under cisplatin. Furthermore, pharmacological inhibition of HDAC2 using Tucidinostat can enhance the sensitivity of TNBC cells to cisplatin therapy. This study not only elucidates the biological function of lactylated METTL3 in tumor cells but also highlights its negative regulatory effect on cisplatin resistance. Additionally, it underscores the nonclassical functional mechanism of Tucidinostat as a HDAC inhibitor for improving the efficacy of cisplatin against TNBC.
Confinement‐Enhanced Multi‐Wavelength Photon Upconversion Based on Triplet–Triplet Annihilation in Nanostructured Glassy Polymers
Authors: Hu Xueqian , Pollice Luca , Ronchi Alessandra , Roccanova Marco , Mauri Michele , Lardani Davide , Vanhecke Dimitri , Monguzzi Angelo , Weder Christoph 
Published: February 2025

AbstractSensitized triplet–triplet annihilation photon upconversion (sTTA‐UC) allows blue‐shifting non‐coherent low‐intensity light and is potentially useful in solar‐powered devices, bioimaging, 3D printing, and other applications. For technologically viable solar energy harvesting systems, solid materials that capture a large fraction of the solar spectrum and efficiently upconvert the absorbed energy must be developed. Here, it is shown that broadband‐to‐blue UC is possible in air‐tolerant, easy‐to‐access, nanostructured polymers comprising a rigid hydrophilic matrix and liquid nanodroplets with dimensions on the order of tens of nanometers. The droplets contain 9,10‐bis[(triisopropylsilyl)ethynyl] anthracene (TIPS‐Ac) as emitter/annihilator and palladium(II) octaethyl porphyrin (PdOEP) and palladium(II) meso‐tetraphenyl tetrabenzoporphine (PdTPBP) as sensitizers. The confinement of the three dyes in the liquid domains renders the various bimolecular energy transfer processes that are pivotal for the TIPS‐Ac's triplet sensitization highly efficient, and the simultaneous use of multiple light harvesters with triplet energy levels resonant with the emitter/annihilator increases the absorption bandwidth to ca. 150 nm. The UC process at low power densities is most efficient when both sensitizers are simultaneously excited, thanks to their confinement in the nanodroplets, which leads to an increase in the triplet density, and therefore TTA rate and yield, optimizing the use of the harvested energy.
The role of intrinsic motivation and continuous enhancement on the intention to implement animal welfare practices in dairy farming
Authors: Grotsch Henrike , Mergenthaler Marcus , Kühl Sarah , Schulze Holger 
Published: February 2025

AbstractAnimal welfare programs alone are insufficient to ensure better welfare for farm animals. Effective farm management, driven by dairy farmers' intrinsic motivation, plays a pivotal role. This study examines the factors influencing dairy farmers' intention to implement animal welfare practices and their commitment to continuously enhancing welfare. Based on a survey of 682 German dairy farmers, the results underscore the importance of intrinsic motivation, habitual behavior, and knowledge acquisition. Farmers' willingness to engage in continuous improvement suggests that policies should focus less on formal programs and more on enabling intrinsic motivation. The study introduces the construct of “continuous enhancement,” offering a novel framework for understanding and improving animal welfare practices.
Harnessing Aggregation‐Induced Emission‐Based Detection Toolbox for Diagnostics of Urogenital Tumors
Authors: Chen Wenzhe , Guan Hantian , Lu Yongfeng , Zeng Guohua , Gu Di , Guo Keying , Jiang Cheng , Liu Hongxing 
Published: February 2025

ABSTRACTUrogenital system tumors include prostate cancer, bladder cancer, ovarian cancer, and other very common solid tumor diseases with high morbidity and high mortality. The unique physiological and anatomical features of the urogenital system render it particularly amenable to the application of tissue imaging techniques for diagnostic purposes. The advancement of aggregation‐induced emission (AIE) materials has addressed the limitations associated with conventional fluorescent materials that are prone to aggregation‐caused quenching. This advancement has facilitated the development of innovative AIE fluorescent materials characterized by enhanced photostability, an increased signal‐to‐noise ratio, and improved imaging quality. This article reviews the research progress of AIE biosensors in the diagnosis of urogenital tumors. It mainly involves biomarker diagnostic in vitro and fluorescence imaging in urogenital solid tumors such as prostate cancer, uterine cancer, bladder cancer, and ovarian cancer, which are based on AIE biosensors. In addition, a comprehensive description of AIE biosensors’ synthesis and application strategies is provided. This includes a detailed elucidation of in vitro diagnostic platforms and intracellular imaging mechanisms based on the basic principles of AIE, accompanied by a presentation of quantitative analysis and cell imaging results. In addition, the limitations, challenges and suggestions of AIE biosensors application in the field of tumor diagnosis are summarized, and the development prospect of AIE biosensors in the field of tumor diagnosis is prospected. This article reviews the application of AIE biosensors in the diagnosis of urogenital tumors, and also provides a catalyst for exploring the characteristics of AIE biosensors and its wide application in the field of disease diagnosis.
An integrated scheduling and control scheme with two economic layers for demand side management of chemical processes
Authors: Schulze Jan C. , Papadimitriou Chrysanthi , Kolmer Paul , Mitsos Alexander 
Published: February 2025

AbstractIntegrated dynamic scheduling (IDS) and economic nonlinear model predictive control (eNMPC) enable economic operation of chemical plants subject to volatile energy prices. Herein, we combine the two concepts into an integrated two‐layer scheme. Therein, IDS performs “long‐horizon” scheduling on a day‐ahead (DA) market and eNMPC “short‐horizon” improvements on an intra‐day (ID) market. A case study demonstrates 5% economic savings over stationary operation. In contrast, stand‐alone IDS and eNMPC using DA prices reach 1% and 2.5% savings, respectively. We identify arbitrage as the main driver generating the additional benefit. Additionally, we compare our scheme to stand‐alone eNMPC in three ID price scenarios, where our approach consistently realizes savings of 5%. Conversely, eNMPC is price sensitive with variable revenue between 1% higher costs and 10% savings. Finally, requiring significantly shorter prediction horizons than stand‐alone eNMPC, our approach eases price forecasting and enhances real‐time capability.
Effect of Polymeric Additives on Aqueous Alumina Ceramic Slurry for Tape Casting
Authors: Chu Yuanzhen , Lyu Yang , Wang Xingjun , Ouyang Xueqiong , Shen Yi , Wang Shuangxi 
Published: February 2025

ABSTRACTA large number of toxic, flammable, and volatile organic solvents are used in the organic tape‐casting process, which have significant adverse effects on both the natural environment and human health. This study reports an aqueous polymer–ceramic slurry suitable for tape casting using water as the solvent instead of traditional organic solvents. The effects of chemical additives (dispersant, binder, plasticizer, and defoamer) on the viscosity, stability, and bubble content of the water‐based alumina ceramic slurry used for aqueous tape casting were investigated. The results showed that when the dispersant (ammonium polyacrylate) (PAA‐NH4) and defoaming agent (M15‐01) contents were 1.5 and 0.1 wt%, respectively, and the ratio of binder (polyvinyl alcohol) (PVA) to plasticizer (glycerol) was 0.6, the surface of the green tape obtained by aqueous tape casting was the smoothest and flattest. Moreover, the alumina ceramic substrate of a size of 100 mm × 100 mm obtained by cutting and sintering the green tape exhibited dielectric constant, thermal conductivity, and breaking tenacity of 9.73, 23.16 W m−1 K−1, and 4.34 MPa m1/2, respectively, making it an ideal candidate for high‐power integrated circuits. This study not only addresses the environmental and health concerns associated with organic solvents but also presents a promising solution for developing advanced aqueous polymer–ceramic slurries.
An Unusual Protuberant Lithophyllum sp. From Southern Spain Increases Structural Complexity in Urchin Barrens
Authors: Ramos Dino Angelo E. , Del Río Jesús , Peñas Julio , Braga Juan C. 
Published: February 2025

ABSTRACTUrchin barrens (‘blanquizales’) are habitats dominated by encrusting non‐geniculate coralline algae and maintained by urchin grazing. Taxonomic information of coralline communities in Mediterranean blanquizales is limited. Lumpy to fruticose coralline algal specimens, unusual in blanquizales, were found along the southern Spanish coast. Sequences from these specimens resolved with foliose samples morpho‐anatomically identified as Lithophyllum dentatum. Initial observations suggested that this protuberant Lithophyllum species increases diversity in the otherwise species‐poor exposed blanquizales. When present, higher macroalgal cover was observed with algae and microfauna frequently observed as epibiotic among the coralline's protuberances.
Electroantennogram and Behavioral Responses of Nematus Hequensis Xiao Adult to Volatiles of Salix alba Leaves
Authors: Song Zhenhao , Chen Yiqu , Dong Xiao , Sun Zhaoxu , Guo Xinnan , Yu Kun , Tang Xiaoqin , Zang Jiancheng 
Published: February 2025

ABSTRACTThe aim of this study was to investigate how leaf volatiles from Salix alba affect the orientation of Nematus hequensis Xiao adults towards host plants and contribute to the development of plant‐based attractants for N. hequensis. Solid‐phase microextraction (SPME) coupled with gas chromatograph‐mass spectrometry (GC‐MS) was used to extract, identify, and screen leaf volatiles from S. alba aged 10–15 years during the peak eclosion of N. hequensis. Electroantennogram (EAG) and Y‐shaped olfactometry assays were utilized to identify volatiles with relative content > 1% and determine the optimal concentration for attracting, 1‐day‐old unmated males and females. The results showed that among the 15 volatiles with a relative content of more than 1%, (E)‐2‐hexenal, benzaldehyde, and 2‐hydroxybenzaldehyde elicited the strongest EAG response in adult males and females at a concentration of 100 μg·μL‐1, with (E)‐2‐hexenal exhibiting a greater effect than 2‐hydroxybenzaldehyde, which in turn was more effective than benzaldehyde. At this concentration, the attractive effects of (E)‐2‐Hexenal, and benzaldehyde on adult males and females were significant. These findings provide an important basis for developing attractants and repellents used in control of this insect pest.
Pd/NHCs‐Catalyzed Denitrative/Dechlorinated N‐Arylation of Nitroarenes/Chloroarenes to Hydrazine Derivatives
Authors: Wang Xuejie , Chen Wei , Chen Wanzhi 
Published: February 2025

Palladium‐catalyzed denitrative/dechlorinated C‐N coupling reactions of nitroaromatics/chloroarenes with hydrazines/hydrazones were performed using sterically bulky N‐heterocyclic ligands (NHC = 2‐aryl‐5‐(2,4,6‐triisopropylphenyl)‐2,3‐imidazolylidene[1,5‐a]pyridines). A range of N‐arylbenzophenone hydrazones/hydrazine derivatives were obtained in good to excellent yields. This protocol provides an efficient method for the preparation of hydrazones/hydrazines via C‐N coupling of inexpensive nitroarenes and chloroarenes.
Organophotocatalytic Three‐Component Assembly of C4‐Cyanoalkylated Phthalazin‐1(2H)‐Ones
Authors: Mishra Poornima , Kant Ruchir , Rastogi Namrata 
Published: February 2025

AbstractThe present work documents construction of C4‐cyanoalkylated phthalazinones under visible light‐mediated conditions. The three‐component reaction involving aryl hydrazines, 2‐formylbenzoic acids and cyclobutanone oxime esters with organic dye Eosin Y as photocatalyst, features initial formation and subsequent cyanoalkylation of phthalazin‐1(2H)‐one in one pot. The reaction is notable for mild conditions, operational simplicity, wide substrate scope and good yields of the products. The phthalazinone products were further converted into other valuable organic derivatives.
Vorhersage der Wirkung trockener Luft auf die Haut durch Kopplung von Gebäudesimulation, Raumluftströmung und Personenmodell
Authors: Rösler Markus , Gritzki Ralf , Kozak Wojciech , Felsmann Clemens 
Published: February 2025

AbstractUm Effekte der Luftfeuchte auf das Raumklima besser abbilden zu können, wurde ein AmI‐Plattformkonzept (AmI = Ambient Intelligence) auf Basis einer integrierten Gebäudesimulation in Verbindung mit einem Personenmodell entwickelt. Hierzu wurden vielfältige Untersuchungen raumklimatischer Situationen in Büros in unterschiedlicher Detaillierung auf Basis gekoppelter Gebäude‐, Anlagen‐ und Raumluftströmungssimulationen durchgeführt. Das Simulationsmodell wurde zudem um ein Personenmodell erweitert, das aus raumklimatischen Bedingungen eine Verdunstungsrate über die Haut generiert. Parallel erfolgten für die experimentelle Bestimmung der Verdunstungsraten in der Bundesanstalt für Arbeitsschutz und Arbeitsmedizin (BAuA) in Dortmund umfangreiche Probandenversuche in einer speziell zu diesem Zweck konzipierten Klimakammer. Die Probandenversuche wurden in zwei Serien durchgeführt und es entstanden für jeweils zwei unterschiedliche Raumtemperaturen, Lüftungsarten und relative Luftfeuchten insgesamt 380 Datensätze. Die Ergebnisse wurden ausführlich dargestellt, bewertet und mit den Daten des weiterentwickelten, neuartigen Simulationsmodells für Gebäude‐, Anlagen‐ und Raumluftströmungsberechnung inklusive Personenmodell verglichen.
Survival Analysis of 4 Different Age Groups of Pancreatic Ductal Adenocarcinoma After Radical Resection From Retrospective Multi‐Center Analysis (YPB‐003)
Authors: Matsui Hiroto , Ioka Tatsuya , Kawaoka Toru , Takahashi Tsuyoshi , Inokuchi Toshihiro , Harada Eijiro , Sakamoto Kazuhiko , Suto Ryuichiro , Maeda Yoshinari , Nishimura Taku , Shindo Yoshitaro , Tokumitsu Yukio , Nakajima Masao , Kimura Yuta , Takami Taro , Ito Katsuyoshi , Tanaka Hidekazu , Hamano Kimikazu , Nagano Hiroaki ,   Yamaguchi Pancreatic/Biliary Disease Study Group (YPB)
Published: February 2025

ABSTRACTAimThis study aimed to investigate the efficacy of radical resection and postoperative adjuvant chemotherapy on the survival benefit in patients with pancreatic ductal adenocarcinoma (PDAC), stratified by age, frailty, and other factors in actual clinical practice.MethodsWe retrospectively analyzed the clinicopathological and follow‐up data of 414 patients with PDAC who underwent surgical resection at nine institutions under the Yamaguchi Pancreat/Biliary Disease Study Group, between January 1997 and December 2016. Recurrence‐free survival (RFS) and overall survival (OS) were calculated using the Kaplan–Meier method. Associations between survival and prognostic factors were evaluated by univariate and multivariate analyses.ResultsThere were 30.5% of patients with PDAC who were aged < 65 years, 37.9% aged 65–74 years, 17.6% aged 75–79 years, and 14.0% aged ≥ 80 years. Notably, RFS declined with increasing age (median RFS: 12.9, 10.2, 9.4, and 7.4 months, respectively), although the differences were not significant (p = 0.223). OS significantly decreased with age (median OS: 21.6, 21.2, 17.0, and 13.9 months, respectively; p = 0.005). In patients aged < 75 years, independent prognostic factors identified by univariate and multivariate analyses included lymph node metastasis (hazard ratio [HR], 1.598; p = 0.007), tumor size (HR, 1.489; p = 0.043), R status (HR, 1.536; p = 0.011), and serum albumin levels (HR, 1.526; p = 0.031). In patients aged ≥ 75 years, a high modified frailty index (HR, 2.446; p = 0.012) emerged as an independent prognostic factor, along with lymph node metastasis, CA19‐9 level (HR, 1.897; p = 0.017), and R status (HR, 2.087; p = 0.007).ConclusionThe prognosis for older patients with PDAC was shorter than that of younger patients. Frailty may contribute to their poorer prognosis in older age.
Macrophage‐to‐Myofibroblast Transition Contributes to Cutaneous Scarring Formation Through the TGF‐β/Smad3 Signaling Pathways
Authors: Jia Yuan , Qin Yi , Yuan Feng‐Lai , Shen Jie‐Hong 
Published: February 2025

ABSTRACTCutaneous scarring typically arises after surgery, trauma, and infection, occurring when normal skin tissue is replaced by fibrous tissue during the healing process. Myofibroblasts have been identified as a significant contributor to this scarring. While the differentiation of fibroblasts into myofibroblasts is well‐recognized as essential for wound healing and tissue repair, the mechanisms underlying the macrophage‐myofibroblast transition (MMT) remain largely unexplored. This study aimed to investigate the role and potential mechanisms of MMT in cutaneous scarring. In specimens of hypertrophic scars, keloid and scleroderma, we confirmed the coexistence of MMT markers CD68 and α‐smooth muscle actin (α‐SMA) in areas of skin fibrosis. Additionally, most MMT cells in human cutaneous scar co‐expressed the M2‐type macrophage marker CD206. Fate‐mapping in Lyz2‐Cre/Rosa26‐tdTomato mice further demonstrated that the majority of myofibroblasts in cutaneous scars were derived from bone marrow macrophages. Furthermore, higher levels of TGF‐β were released from scar fibroblasts, which contributed to MMT through the Smad3 pathways. In vivo studies inhibiting Smad3 reduced MMT and scarring. Macrophage depletion with clodronate liposomes also reduced cutaneous scar formation. Our findings indicate that MMT plays a pivotal role in cutaneous scarring through the TGF‐β/Smad3 pathways. Consequently, inhibiting MMT may be a novel strategy for the treatment of cutaneous scarring.
Long‐Term Outcomes of Stent‐Less Strategy Using Directional Coronary Atherectomy for the Ostial Left Circumflex Artery
Authors: Matsumura Hidenari , shimoji Kenichiro 
Published: February 2025

ABSTRACTBackgroundLong‐term outcomes of percutaneous coronary intervention (PCI) for left circumflex artery (LCX) ostial lesions remain suboptimal. While a stent‐less strategy using directional coronary atherectomy (DCA) and drug‐eluting balloon (DEB) may offer a potential solution, no studies have reported on its long‐term outcomes.AimsThis study aims to evaluate the long‐term outcomes of a stent‐less PCI strategy using DCA and DEB for LCX ostial lesions.MethodsWe retrospectively analyzed consecutive patients treated for LCX ostial lesions with DCA to reduce plaque area to < 60%, followed by DEB angioplasty, at Saiseikai Utsunomiya Hospital, Tochigi, Japan, between January 2019 and January 2024. The primary endpoint was clinically driven target lesion revascularization. Secondary endpoints included major adverse cardiac events, defined as a composite of cardiac death, myocardial infarction (MI), and ischemia‐driven target vessel revascularization, as well as bleeding complications.ResultsTen patients were included, five of whom had diabetes mellitus. A total of 80% had concomitant left main trunk (LMT) to left anterior descending artery (LAD) lesions; 60% underwent crossover stenting for LMT‐LAD after LCX DCA, while two were treated with DCA and DEB for both LCX and LMT‐LAD. All patients underwent follow‐up using coronary computed tomography or angiography, with a follow‐up period ranging from 8 to 56 months (median: 22 months, IQR: 21.7). TLR occurred in one patient (10%). No cases of cardiac death, MI, or bleeding complications were observed.ConclusionsDCA followed by DEB demonstrated favorable long‐term outcomes for LCX ostial lesions, providing a viable alternative to conventional stent‐based PCI strategies.
Left Ventricular Apical Thrombosis as an Early Alarming Indicator of Left Ventricular Apical Pseudoaneurysm
Authors: Fallah Flora , Asl‐Fallah Sahar , Ghorbanzadeh‐Aghdam Mani , Hosseinsabet Ali 
Published: February 2025

ABSTRACTIn patients with myocardial infarction, left ventricular pseudoaneurysm is uncommon and may present insidiously. Left ventricular apical thrombosis may accompany the left ventricular apical pseudoaneurysm and may be an early alarming indicator. Accordingly, close follow‐up of patients with left ventricular apical thrombosis in the context of myocardial infarction via appropriate imaging modalities may be required.