bluuebunny/crossref_metadata_2025_split huggingface dataset:
FENOMENA LINGUISTIS GADIS AUTIS DALAM FILM INNOCENT WITNESS: KAJIAN PSIKOLINGUISTIK
Authors: Santosa Farihanum Shania Izza , Labibah Jihan , Herowati Kurnia Sari 
Published: June 2024

Penelitian ini mengkaji fenomena linguistik gangguan berbahasa gadis autis dengan sindrom Asperger dalam film Innocent Witness karya Lee Han. Metode deskriptif kualitatif digunakan untuk mendapatkan pemahaman yang lebih mendalam tentang kondisi tersebut, dengan pendekatan yang mencakup analisis teori Scovel tentang tahapan konseptualisasi, formulasi, artikulasi, dan pemantauan diri dalam produksi bahasa. Teknik pengumpulan data melibatkan peninjauan film,z transkripsi dialog, dan analisis isi untuk mengidentifikasi gangguan berbahasa yang dialami karakter autis. Tujuan penelitian ini adalah untuk memahami kondisi autisme, khususnya sindrom Asperger, yang memengaruhi kemampuan berbahasa dan komunikasi karakter Ji-woo. Hasil penelitian mengungkapkan dominasi gangguan konseptualisasi dalam interaksi Ji-woo, menyoroti tantangan yang dihadapi individu dengan autisme dalam berkomunikasi. Penelitian ini diharapkan dapat meningkatkan kesadaran publik tentang autisme, serta mendorong penerimaan dan inklusi yang lebih baik bagi individu dengan gangguan berbahasa dalam masyarakat.
Biphasic bone substitutes coated with PLGA incorporating therapeutic ions Sr2+ and Mg2+: cytotoxicity cascade and in vivo response of immune and bone regeneration
Authors: Ren Yanru , Jung Ole , Batinic Milijana , Burckhardt Kim , Görke Oliver , Alkildani Said , Köwitsch Alexander , Najman Stevo , Stojanovic Sanja , Liu Luo , Prade Ina , Barbeck Mike 
Published: June 2024

The incorporation of bioactive ions into biomaterials has gained significant attention as a strategy to enhance bone tissue regeneration on the molecular level. However, little knowledge exists about the effects of the addition of these ions on the immune response and especially on the most important cellular regulators, the macrophages. Thus, this study aimed to investigate the in vitro cytocompatibility and in vivo regulation of bone remodeling and material-related immune responses of a biphasic bone substitute (BBS) coated with metal ions (Sr2+/Mg2+) and PLGA, using the pure BBS as control group. Initially, two cytocompatible modified material variants were identified according to the in vitro results obtained following the DIN EN ISO 10993-5 protocol. The surface structure and ion release of both materials were characterized using SEM-EDX and ICP-OES. The materials were then implanted into Wistar rats for 10, 30, and 90 days using a cranial defect model. Histopathological and histomorphometrical analyses were applied to evaluate material degradation, bone regeneration, osteoconductivity, and immune response. The findings revealed that in all study groups comparable new bone formation were found. However, during the early implantation period, the BBS_Sr2+ group exhibited significantly faster regeneration compared to the other two groups. Additionally, all materials induced comparable tissue and immune responses involving high numbers of both pro-inflammatory macrophages and multinucleated giant cells (MNGCs). In conclusion, this study delved into the repercussions of therapeutic ion doping on bone regeneration patterns and inflammatory responses, offering insights for the advancement of a new generation of biphasic calcium phosphate materials with potential clinical applicability.
Potential perioperative cardiovascular outcomes in cannabis/cannabinoid users. A call for caution
Authors: Echeverria-Villalobos Marco , Guevara Yosira , Mitchell Justin , Ryskamp David , Conner Joshua , Bush Margo , Periel Luis , Uribe Alberto , Weaver Tristan E. 
Published: June 2024

BackgroundCannabis is one of the most widely used psychoactive substances. Its components act through several pathways, producing a myriad of side effects, of which cardiovascular events are the most life-threatening. However, only a limited number of studies address cannabis's perioperative impact on patients during noncardiac surgery.MethodsStudies were identified by searching the PubMed, Medline, EMBASE, and Google Scholar databases using relevant keyword combinations pertinent to the topic.ResultsCurrent evidence shows that cannabis use may cause several cardiovascular events, including abnormalities in cardiac rhythm, myocardial infarction, heart failure, and cerebrovascular events. Additionally, cannabis interacts with anticoagulants and antiplatelet agents, decreasing their efficacy. Finally, the interplay of cannabis with inhalational and intravenous anesthetic agents may lead to adverse perioperative cardiovascular outcomes.ConclusionsThe use of cannabis can trigger cardiovascular events that may depend on factors such as the duration of consumption, the route of administration of the drug, and the dose consumed, which places these patients at risk of drug-drug interactions with anesthetic agents. However, large prospective randomized clinical trials are needed to further elucidate gaps in the body of knowledge regarding which patient population has a greater risk of perioperative complications after cannabis consumption.
3D deformation analysis for earth dam monitoring based on terrestrial laser scanning (TLS) and the iterative closest point (ICP) algorithm
Authors: Ning Xing-Yi , Zhang Kun , Jiang Nan , Luo Xiang-Long , Zhang Dong-Ming , Peng Ju-Wei , Luo Xiao-Xiong , Zheng Yong-Sheng , Guo Ding 
Published: June 2024

Introduction: The conventional 3-D point cloud-based deformation analysis methods, such as the shortest distance (SD), cloud-to-cloud (C2C), and multiscale model-to-model cloud comparison (M3C2), essentially regard the closest distance between two periods of point cloud data as the deformation, rather than the true position of the same point in 3-D space before and after deformation.Methods: This paper proposes a method based on the ICP algorithm to calculate the differences between the chunked multi-period point clouds to recognizes the 3-D deformations.Results and discussion: The results show that the obtained results are very close to the GNSS data but with a much larger spatial monitoring range. The accuracy is higher than that of the SD method. Moreover, we analyze the statistical relationship between the point cloud block size and the deformation vector error and determine the optimal block size. The aim of this article is to optimize the deformation analysis method and improve its accuracy to provide techniques and ideas for the wider surface deformation monitoring research field. For instance, combining this method with data from contact methods constructs a 3D overall deformation model of the mountain, enabling real-time monitoring and early warning of debris flows.
Association between life’s essential 8 and male biochemical androgen deficiency: evidence from NHANES 2013–2016
Authors: Huang Weisheng , Chen Mutong , Zhang Haiyu , Zhang Zhongfu , Yin Cong , Huang Meiyang , Shi Bentao 
Published: June 2024

PurposeTo evaluate the association of Life’s Essential 8 (LE8) and its subscales with male biochemical androgen deficiency (MBAD) and total testosterone based on the data from the national health and nutrition examination survey (NHANES) database.MethodsData of males aged 20 years or older from NHANES of 2013–2016 were extracted. LE8 score was calculated based on American Heart Association definitions. Total testosterone (TT) values were measured in NHANES using precise isotope dilution liquid chromatography. MBAD was defined as serum TT of &lt;300 ng/dL. Univariate and multivariable analyses were conducted. Propensity score matching (PSM) and weighted regression after matching were added as sensitivity analyses. The generalized additive model, smooth curve fitting, and the recursive algorithm were used to determine the potential inflection points. Piecewise regression models with log-likelihood ratio test were used to quantify nonlinear effects.ResultsA total of 3094 participants who were males and aged 20 years or above were included. Out of them, 805 males were diagnosed with MBAD. After adjusting the confounders in the multivariable model, LE8 was independently associated with MBAD (OR 0.96, P &lt; 0.001) and TT (β 2.7, P &lt; 0.001). The association remained robust even after PSM. The non-linear relationship of LE8 behaviors score with MBAD and TT was revealed.ConclusionLE8 was an independent protective factor of MBAD and a feasible approach to promote male endocrine sexual function.
The impact of clomiphene citrate on the endometrium in comparison to gonadotropins in intrauterine insemination cycles: is it thinner and does it matter?
Authors: Lu Yao , Cherouveim Panagiotis , Jiang Victoria , Dimitriadis Irene , James Kaitlyn E. , Bormann Charles , Souter Irene 
Published: June 2024

ObjectiveTo determine whether endometrial thickness (EMT) differs between i) clomiphene citrate (CC) and gonadotropin (Gn) utilizing patients as their own controls, and ii) patients who conceived with CC and those who did not. Furthermore, to investigate the association between late-follicular EMT and pregnancy outcomes, in CC and Gn cycles.MethodsRetrospective study. Three sets of analyses were conducted separately for the purpose of this study. In analysis 1, we included all cycles from women who initially underwent CC/IUI (CC1, n=1252), followed by Gn/IUI (Gn1, n=1307), to compare EMT differences between CC/IUI and Gn/IUI, utilizing women as their own controls. In analysis 2, we included all CC/IUI cycles (CC2, n=686) from women who eventually conceived with CC during the same study period, to evaluate EMT differences between patients who conceived with CC (CC2) and those who did not (CC1). In analysis 3, pregnancy outcomes among different EMT quartiles were evaluated in CC/IUI and Gn/IUI cycles, separately, to investigate the potential association between EMT and pregnancy outcomes.ResultsIn analysis 1, when CC1 was compared to Gn1 cycles, EMT was noted to be significantly thinner [Median (IQR): 6.8 (5.5–8.0) vs. 8.3 (7.0–10.0) mm, p&lt;0.001]. Within-patient, CC1 compared to Gn1 EMT was on average 1.7mm thinner. Generalized linear mixed models, adjusted for confounders, revealed similar results (coefficient: 1.69, 95% CI: 1.52–1.85, CC1 as ref.). In analysis 2, CC1 was compared to CC2 EMT, the former being thinner both before [Median (IQR): 6.8 (5.5–8.0) vs. 7.2 (6.0–8.9) mm, p&lt;0.001] and after adjustment (coefficient: 0.59, 95%CI: 0.34–0.85, CC1 as ref.). In analysis 3, clinical pregnancy rates (CPRs) and ongoing pregnancy rates (OPRs) improved as EMT quartiles increased (Q1 to Q4) among CC cycles (p&lt;0.001, p&lt;0.001, respectively), while no such trend was observed among Gn cycles (p=0.94, p=0.68, respectively). Generalized estimating equations models, adjusted for confounders, suggested that EMT was positively associated with CPR and OPR in CC cycles, but not in Gn cycles.ConclusionsWithin-patient, CC generally resulted in thinner EMT compared to Gn. Thinner endometrium was associated with decreased OPR in CC cycles, while no such association was detected in Gn cycles.
Cardiovascular adverse events associated with immune checkpoint inhibitors: a meta-analysis
Authors: Li Xi , Li Dan 
Published: June 2024

ObjectiveTo evaluate the cardiovascular safety of anticancer drug immune checkpoint inhibitors (ICIs) used in patients with malignant tumors.MethodsFour clinical research databases that have been completed since their establishment were searched, and the odds ratios and 95% confidence intervals of each indicator were statistically calculated.Results62 randomized controlled trial and controlled trials were included. In single drug treatment ICIs group, the overall risk of cardio cerebral Vascular disease at all levels was higher than that in the placebo/chemotherapy group. Especially in all grades of Myocarditis and above grade 3 compared with normal controls, except for pericardial lesions, other indicators have no obvious side effects.ConclusionSingle drug use of an anti-tumor ICIs may increase cardiovascular side effects risk in cancer patients, so we need to strengthen monitoring, identification and management, and timely intervention to manage ICI induced adverse events.
Inhibiting SIRT-2 by AK-7 restrains airway inflammation and oxidative damage promoting lung resurgence through NF-kB and MAP kinase signaling pathway
Authors: Yadav Vandana , Pandey Vinita , Gaglani Pratikkumar , Srivastava Atul , Soni  , Subhashini  
Published: June 2024

IntroductionChronic obstructive pulmonary disease (COPD) is a major global cause of mortality with limited effective treatments. Sirtuins (SIRT) are histone deacetylases that are involved in the regulation of redox and inflammatory homeostasis. Hence, the present study aims to investigate the role of SIRT-2 in modulating inflammation in a murine model of COPD.MethodsCOPD in mice was established by cigarette smoke (CS) exposure for 60 days, and AK-7 was used as the specific SIRT-2 inhibitor. AK-7 (100 µg/kg and 200 µg/kg body weight) was administered intranasally 1 h before CS exposure. Molecular docking was performed to analyze the binding affinity of different inflammatory proteins with AK-7.ResultsImmune cell analysis showed a significantly increased number of macrophages (F4/80), neutrophils (Gr-1), and lymphocytes (CD4+, CD8+, and CD19+) in the COPD, group and their population was declined by AK-7 administration. Total reactive oxygen species, total inducible nitric oxide synthase, inflammatory mediators such as neutrophil elastase, C-reactive protein, histamine, and cytokines as IL4, IL-6, IL-17, and TNF-α were elevated in COPD and declined in the AK-7 group. However, IL-10 showed reverse results representing anti-inflammatory potency. AK-7 administration by inhibiting SIRT-2 decreased the expression of p-NF-κB, p-P38, p-Erk, and p-JNK and increased the expression of Nrf-2. Furthermore, AK-7 also declined the lung injury by inhibiting inflammation, parenchymal destruction, emphysema, collagen, club cells, and Kohn pores. AK-7 also showed good binding affinity with inflammatory proteins.DiscussionThe current study reveals that SIRT-2 inhibition mitigates COPD severity and enhances pulmonary therapeutic interventions, suggesting AK-7 as a potential therapeutic molecule for COPD medication development.
Analysis of physical activity in psoriatic arthritis: relationship with clinical and analytical parameters and comorbidity—description of the sedentary patient
Authors: Toledano Esther , Chacón Carolina Cristina , Compán Olga , Gómez-Lechón Luis , Hidalgo Cristina , Ibañez Marta , Márquez Antonio , Montilla Carlos 
Published: June 2024

ObjectiveThis study aimed to relate physical activity and a sedentary lifestyle to clinical, biological, functional, and comorbid parameters in a cohort of patients with psoriatic arthritis (PsA).MethodsA cross-sectional study was conducted with 232 PsA patients. Physical activity and sedentary lifestyle were obtained using the International Physical Activity Questionnaire (IPAQ) questionnaire. The demographic, clinical, and biological variables measured were age, time since PsA diagnosis, smoking, type of treatment used, clinical form, presence of enthesitis, dactylitis (present or past), fatigue, tumor necrosis factor (TNF)-alpha, and interleukin 6 (IL-6). Activity and functionality were measured using the Disease Activity Index for Psoriatic Arthritis (DAPSA) and Health Assessment Questionnaire (HAQ) in peripheral forms, while the Ankylosing Spondylitis Disease Activity Score (ASDAS-PCR) and Bath Ankylosing Spondylitis Functional Index (BASFI) were measured in axial forms. Disease impact was assessed using the Psoriatic Arthritis Impact of Disease (PsAID) questionnaire. Alongside comorbidities, obesity, anxiety, depression [Hospital Anxiety and Depression Scale (HADS)], and sleep quality [Insomnia Severity Index (ISI)] were assessed.ResultsThe mean age was 54.6 (SD: 11.4) years, with 54.3% being male. A total of 25.6% of patients were sedentary. Physical activity and sedentary lifestyle were inversely correlated with fatigue, activity, functionality, and disease impact. Within comorbidities, they correlated with anxiety, depression, and insomnia. In addition, physical activity was inversely correlated with obesity. In linear regression analysis, physical activity was found to be related to body mass index (BMI) with a ß coefficient of −0.1 (p &lt; 0.04; 95%CI: −194.1–−4.5), and an R2 value of 0.11. In logistic regression analysis, a sedentary lifestyle was found to be related to pain, with an odds ratio (OR) of 1.5 (p &lt; 0.001; 95%CI:1.1–1.8) and an R2 Nagelkerke value of 0.36.ConclusionA quarter of the patients were sedentary. Lack of physical activity correlated with worse parameters of clinical activity, functionality, disease impact, and the presence of comorbidities.
The association between vitamin D and the progression of diabetic nephropathy: insights into potential mechanisms
Authors: Gao Jiachen , Song Xiujun , Ou Hongling , Cheng Xiyu , Zhang Lishu , Liu Chen , Dong Ya , Wang Xinru 
Published: June 2024

AimsVitamin D deficiency (VDD) is prevalent in the population, with inadequate intake, impaired absorption and metabolism as the main causative factors. VDD increases the risk of developing chronic diseases such as type 2 diabetes mellitus (T2DM) and diabetic nephropathy (DN), but the molecular mechanisms underlying this phenomenon are not known. The aim of this study was to investigate the association and potential mechanisms of vitamin D levels with the progression of DN by analyzing general clinical data and using bioinformatics methods.MethodsThe study included 567 diabetes mellitus type 2 (T2DM) patients from the Rocket Force Characteristic Medical Center as the case group and 221 healthy examinees as the normal control group. T2DM patients were categorized into T2DM, early diabetic nephropathy (EDN), and advanced diabetic nephropathy (ADN) based on the progression of diabetic nephropathy. The renal RNA-seq and scRNA-seq data of patients with DN were mined from public databases, and the differential expression of vitamin D-related genes in normal-EDN-ADN was analyzed by bioinformatics method, protein interaction network was constructed, immune infiltration was evaluated, single cell map was drawn, and potential mechanisms of VD and DN interaction were explored.ResultsChi-square test showed that vitamin D level was significantly negatively correlated with DN progression (p &lt; 0.001). Bioinformatics showed that the expression of vitamin D-related cytochrome P450 family genes was down-regulated, and TLR4 and other related inflammatory genes were abnormally up-regulated with the progression of DN. Vitamin D metabolism disturbance up-regulate “Nf-Kappa B signaling pathway,” B cell receptor signaling pathway and other immune regulation and insulin resistance related pathways, and inhibit a variety of metabolic pathways. In addition, vitamin D metabolism disturbance are strongly associated with the development of diabetic cardiomyopathy and several neurological disease complications.ConclusionVDD or vitamin D metabolism disturbance is positively associated with the severity of renal injury. The mechanisms may involve abnormal regulation of the immune system by vitamin D metabolism disturbance, metabolic suppression, upregulation of insulin resistance and inflammatory signalling pathways.
The effect of EMS, IFC, and TENS on patient-reported outcome measures for chronic low back pain: a systematic review and meta-analysis
Authors: Wolfe Daniel , Rosenstein Brent , Fortin Maryse 
Published: June 2024

IntroductionChronic low back pain (CLBP) is the leading cause of years lived with disability worldwide. Transcutaneous electrotherapies have been widely used to treat CLBP but, with the partial exception of transcutaneous electrical nerve stimulation (TENS), their effect on pain, disability, quality-of-life, and psychosocial outcomes have not been systematically reviewed. The purpose of this systematic review and meta-analysis was to clarify the overall effect of transcutaneous electrotherapies on patient-reported outcome measures (PROMs) in CLBP patients.MethodsFour databases and two study registries were searched for studies that utilized transcutaneous electrotherapies as a primary intervention for CLBP, compared against active or passive controls. Two reviewers independently extracted study data and assessed risk of bias. Studies were grouped by intervention vs. comparison, and by time of follow-up. Meta-analyses were conducted where appropriate.ResultsA total of 89 full-text were assessed for eligibility; 14 studies were included, with 6 in the meta-analyses (all TENS or mixed TENS). Pain: meta-analyses revealed no significant difference for TENS vs. active control, TENS vs. passive control, or mixed TENS vs. active control at post-intervention, nor for mixed TENS vs. active control at 1-month post-intervention. Interferential current (IFC) was more effective than active control (2 studies), while electromyostimulation (EMS) was generally superior to passive, but not active, controls (6 studies).DisabilityMeta-analyses revealed no significant difference for TENS vs. active control at post-intervention, mixed TENS vs. active control at post-intervention, or mixed TENS vs. active control at 1-month post-intervention. IFC was more effective than active control (2 studies), while the EMS results were mixed (6 studies). We were unable to perform meta-analyses for quality-of-life or psychosocial outcomes.ConclusionThere is moderate evidence that TENS is similar to all controls for improving pain and disability. There is limited evidence that IFC is superior to active controls for improving pain and disability. There is limited evidence that EMS is superior to passive but not active controls for improving pain, and similar to all controls for improving disability.Systematic Review Registrationhttps://www.crd.york.ac.uk/prospero/display_record.php?RecordID=452851, Identifier (CRD42023452851).
Clinical and hematological characteristics of children infected with the omicron variant of SARS-CoV-2: role of the combination of the neutrophil: lymphocyte ratio and eosinophil count in distinguishing severe COVID-19
Authors: Jin Qiaoyan , Ma Wenxian , Zhang Wei , Wang Huiyuan , Geng Yiongxiang , Geng Yan , Zhang Yang , Gao Dan , Zhou Jing , Li Lin , Gou Yaping , Zhong Bo , Li Jing , Hou Wei , Lu Shemin 
Published: June 2024

PurposeInvestigate the clinical/hematological characteristics of children infected with the Omicron variant of severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) and identify an effective indicator to distinguish coronavirus disease 2019 (COVID-19) severity in children.MethodsA retrospective study was conducted through electronic medical records from pediatric patients. The demographic, clinical, and routine blood test (RBT) features of children diagnosed by real-time PCR for SARS-CoV-2 were collected.ResultsData of 261 patients were analyzed. The most common abnormality shown by RBTs was increased monocyte count (68%). Children had “mild-moderate” or “severe” forms of COVID-19. Prevalence of abnormal neutrophil count (p = 0.048), eosinophil count (p = 0.006), mean corpuscular volume (p = 0.033), mean platelet volume (p = 0.006), platelet-large cell ratio (p = 0.043), and red blood cell distribution width-standard deviation (p = 0.031) were significantly different in the two types. A combination of the neutrophil: lymphocyte ratio (NLR) and eosinophil count for diagnosing severe COVID-19 presented the largest AUC (0.688, 95% CI = 0.599–0.777; p &lt; 0.001), and the AUC increased with a decrease in age.ConclusionsCombination of the NLR and eosinophil count might be a promising indicator for identifying severe COVID-19 in children at infection onset.