bluuebunny/crossref_metadata_2025_split huggingface dataset:
TOPOIIα and HER‐2/neu overexpression/amplification in Barrett’s oesophagus, dysplasia and adenocarcinoma
Authors: Rossi Elisa , Villanacci Vincenzo , Bassotti Gabrio , Donato Francesco , Festa Andrea , Cengia Gianpaolo , Grisanti Salvatore , Cestari Renzo 
Published: June 2010

Rossi E, Villanacci V, Bassotti G, Donato F, Festa A, Cengia G, Grisanti S & Cestari R (2010) Histopathology 57, 81–89 TOPOIIα and HER‐2/neu overexpression/amplification in Barrett’s oesophagus, dysplasia and adenocarcinomaAims:  Topoisomerase IIα (TOPOIIα) and HER‐2/neu are chromosome 17q genes coamplified in various cancers; no data exist for Barrett’s oesophagus (BO) and BO adenocarcinoma (ADC). The aim was to investigate gene amplification and protein overexpression of TopoIIα and Her‐2/neu in non‐dysplastic BO, dysplastic BO, Barrett ADC, and chromosome 17 aneusomy.Methods and results:  Forty‐four patients [18 BO, 13 BO with dysplasia (five low‐grade dysplasia, eight high‐grade dysplasia) and 13 ADC in BO] were evaluated by immunohistochemistry and fluorescence in situ hybridization (FISH). Genes (HER‐2/neu and TOPOIIα) and chromosome 17 were evaluated by FISH. Patients with BO, dysplasia and ADC were compared. A significant association was found between TOPOIIα protein overexpression and TopoIIα gene amplification, chromosome 17 aneusomy, HER‐2/neu gene amplification and HER‐2 protein overexpression as well as between HER‐2 protein and HER‐2/neu gene, TopoIIα gene and aneusomy for chromosome17, and between the genes TOPOIIα and HER‐2/neu. Gene amplification (HER‐2/neu, TOPOIIα), protein overexpression (HER‐2/TOPOIIα), and chromosome 17 aneusomy were associated with dysplasia or ADC. Most BO patients showed no amplification/overexpression/aneusomy for the above genes, proteins and chromosome, with no differences between dysplasia and ADC.Conclusions:  HER‐2/neu and TOPOIIα amplification/overexpression might discriminate between BO and dysplasia/ADC. Chromosome 17 aneusomy is associated with dysplasia or ADC in BO.
Managing breastfeeding and work: a Foucauldian secondary analysis
Authors: Payne Deborah , Nicholls David A. 
Published: June 2010

payne d. & nicholls d.a. (2010) Managing breastfeeding and work: a Foucauldian secondary analysis. Journal of Advanced Nursing 66(8), 1810–1818.AbstractTitle.  Managing breastfeeding and work: a Foucauldian secondary analysis. Aim. This paper is a report of a secondary analysis of the experiences of employed breastfeeding mothers.Background. Health promotion policies exhort mothers to feed their infants breastmilk exclusively for the first 6 months and partially until the age of 2 years. More mothers are returning to paid employment less than a year after having a baby. Combining breastfeeding and paid work is an issue for nursing and midwifery as predominantly female professions caring for women and their children.Method. Foucauldian discourse analysis was used for a secondary analysis of interviews performed in 2005 with 20 women who continued to breastfeed on their return to work. The discursive positions and disciplinary practices were identified and analysed.Findings. Combining breastfeeding and paid work required negotiating the positions of good mother and good worker. Being a good mother conferred health benefits on infants. Being a good worker required the mothers to constrain their breastfeeding practices. The practices performed by the mothers involved stockpiling breastmilk, maintaining milk supply, preparing the baby ready for absence, making sacrifices and remaining silent and invisible as a breastfeeding worker.Conclusion. Breastfeeding workers have the potential to threaten the focus of the workplace. They discipline themselves to minimize their disruptive potential. Such strategies serve to maintain the marginalization of breastfeeding in the workplace and to keep women’s efforts to continue breastfeeding invisible. The work of breastfeeding workers needs to be better recognized and supported.
The Pregnant Women with HIV Attitude Scale: development and initial psychometric evaluation
Authors: Tyer‐Viola Lynda A. , Duffy Mary E. 
Published: June 2010

tyer‐viola l.a. & duffy m.e. (2010) The Pregnant Women with HIV Attitude Scale: development and initial psychometric evaluation. Journal of Advanced Nursing 66(8), 1852–1863.AbstractTitle.  The Pregnant Women with HIV Attitude Scale: development and initial psychometric evaluation. Aim.  This paper is a report of the development and initial psychometric evaluation of the Pregnant Women with HIV Attitude Scale.Background.  Previous research has identified that attitudes toward persons with HIV/AIDS have been judgmental and could affect clinical care and outcomes. Stigma towards persons with HIV has persisted as a barrier to nursing care globally. Women are more vulnerable during pregnancy. An instrument to specifically measure obstetric care provider’s attitudes toward this population is needed to target identified gaps in providing respectful care.Methods.  Existing literature and instruments were analysed and two existing measures, the Attitudes about People with HIV Scale and the Attitudes toward Women with HIV Scale, were combined to create an initial item pool to address attitudes toward HIV‐positive pregnant women. The data were collected in 2003 with obstetric nurses attending a national conference in the United States of America (N = 210). Content validity was used for item pool development and principal component analysis and analysis of variance were used to determine construct validity. Reliability was analysed using Cronbach’s Alpha.Results.  The new measure demonstrated high internal consistency (alpha estimates = 0·89). Principal component analysis yielded a two‐component structure that accounted for 45% of the total variance: Mothering‐Choice (alpha estimates = 0·89) and Sympathy‐Rights (alpha estimates = 0·72).Conclusion.  These data provided initial evidence of the psychometric properties of the Pregnant Women with HIV Attitude Scale. Further analysis is required of the validity of the constructs of this scale and its reliability with various obstetric care providers.
Living alone with dementia: an interpretive phenomenological study with older women
Authors: De Witt Lorna , Ploeg Jenny , Black Margaret 
Published: June 2010

de witt l., ploeg j. & black m. (2010) Living alone with dementia: an interpretive phenomenological study with older women. Journal of Advanced Nursing 66(8), 1698–1707.AbstractTitle.  Living alone with dementia: an interpretive phenomenological study with older women. Aim.  This paper is a report of a study of the meaning of living alone from the perspective of older people with dementia.Background.  Risks and problems experienced by older women living alone have been investigated mostly through quantitative research. Balancing their safety and autonomy is a serious international community care dilemma. Older people’s perspectives have been muted in qualitative research on living alone with dementia.Method.  Using an interpretive phenomenological approach and van Manen’s method, 14 interviews were conducted in Ontario, Canada from January 2004 to April 2005 with eight older women diagnosed with Alzheimer disease or a related dementia.Findings.  The theme holding back time expressed the temporal meaning of living alone. Pharmacological treatments represented stored time, offering the opportunity to hold back future dreaded time. Past experience with others with dementia was a context for holding on to now and facing some risks of living alone with memory loss. The women acknowledged the limited time remaining for, and identified endpoints to, living alone.Conclusion.  Insight into the impact of past experience with others with dementia could inform nursing assessment and advocacy for health/social services that are sensitive to the potential emotional impact of mixing people with varied levels of dementia in the same programme.
Effectiveness of the implementation of an evidence‐based nursing model using participatory action research in oncohematology: research protocol
Authors: Abad‐Corpa Eva , Meseguer‐Liza Cristobal , Martínez‐Corbalán José Tomás , Zárate‐Riscal Lourdes , Caravaca‐Hernández Amor , Paredes‐Sidrach de Cardona Antonio , Carrillo‐Alcaraz Andrés , Delgado‐Hito Pilar , Cabrero‐García Julio 
Published: June 2010

abad‐corpa e., meseguer‐liza c., martínez‐corbalán j.t., zárate‐riscal l., caravaca‐hernández a., paredes‐sidrach de cardona a., carrillo‐alcaraz a., delgado‐hito p. & cabrero‐garcía j. (2010) Effectiveness of the implementation of an evidence‐based nursing model using participatory action research in oncohematology: research protocol. Journal of Advanced Nursing 66(8), 1845–1851.AbstractTitle.  Effectiveness of the implementation of an evidence‐based nursing model using participatory action research in oncohematology: research protocol. Aim.  To generate changes in nursing practice introducing an evidence‐based clinical practice (EBCP) model through a participatory process. To evaluate the effectiveness of the changes in terms of nurse‐sensitive outcome (NSO).Background.  For international nursing science, it is necessary to explore the reasons for supporting EBCP and evaluate the real repercussions and effectiveness.Methods.  A mixed methods study with a sequential transformative design will be conducted in the bone marrow transplant unit of a tertiary‐level Spanish hospital, in two time periods >12 months (date of approval of the protocol: 2006). To evaluate the effectiveness of the intervention, we will use a prospective quasi‐experimental design with two non‐equivalent and non‐concurrent groups. NSO and patient health data will be collected: (a) impact of psycho‐social adjustment; (b) patient satisfaction; (c) symptom control; (d) adverse effects. All patients admitted during the period of time will be included, and all staff working on the unit during a participatory action research (PAR). The PAR design will be adopted from a constructivist paradigm perspective, following Checkland’s “Soft Systems” theoretical model. Qualitative techniques will be used: 2‐hour group meetings with nursing professionals, to be recorded and transcribed. Field diaries (participants and researchers) will be drawn up and data analysis will be carried out by content analysis.Discussion.  PAR is a rigorous research method for introducing changes into practice to improve NSO.
Comparing self‐guided learning and educator‐guided learning formats for simulation‐based clinical training
Authors: Brydges Ryan , Carnahan Heather , Rose Don , Dubrowski Adam 
Published: June 2010

brydges r., carnahan h., rose d. & dubrowski a. (2010) Comparing self‐guided learning and educator‐guided learning formats for simulation‐based clinical training.Journal of Advanced Nursing 66(8), 1832–1844.AbstractTitle. Comparing self‐guided learning and educator‐guided learning formats for simulation‐based clinical training.Aim. In this paper, we tested the over‐arching hypothesis that progressive self‐guided learning offers equivalent learning benefit vs. proficiency‐based training while limiting the need to set proficiency standards.Background. We have shown that self‐guided learning is enhanced when students learn on simulators that progressively increase in fidelity during practice. Proficiency‐based training, a current gold‐standard training approach, requires achievement of a criterion score before students advance to the next learning level.Methods. Baccalaureate nursing students (n = 15/group) practised intravenous catheterization using simulators that differed in fidelity (i.e. students’ perceived realism). Data were collected in 2008. Proficiency‐based students advanced from low‐ to mid‐ to high‐fidelity after achieving a proficiency criterion at each level. Progressive students self‐guided their progression from low‐ to mid‐ to high‐fidelity. Yoked control students followed an experimenter‐defined progressive practice schedule. Open‐ended students moved freely between the simulators. One week after practice, blinded experts evaluated students’ skill transfer on a standardized patient simulation. Group differences were examined using analyses of variance.Results. Proficiency‐based students scored highest on the high‐fidelity post‐test (effect size = 1·22). An interaction effect showed that the Progressive and Open‐ended groups maintained their performance from post‐test to transfer test, whereas the Proficiency‐based and Yoked control groups experienced a significant decrease (P < 0·05). Surprisingly, most Open‐ended students (73%) chose the progressive practice schedule.Conclusion. Progressive training and proficiency‐based training resulted in equivalent transfer test performance, suggesting that progressive students effectively self‐guided when to transition between simulators. Students’ preference for the progressive practice schedule indicates that educators should consider this sequence for simulation‐based training.
Women’s toileting behaviour related to urinary elimination: concept analysis
Authors: Wang Kefang , Palmer Mary H. 
Published: June 2010

wang k. & palmer m.h. (2010) Women’s toileting behaviour related to urinary elimination: concept analysis. Journal of Advanced Nursing 66(8), 1874–1884.AbstractTitle.  Women’s toileting behaviour related to urinary elimination: concept analysis. Aim.  This paper is a report of analysis of the concept of women’s toileting behaviour related to urinary elimination.Background.  Behaviours related to emptying urine from the bladder can contribute to bladder health problems. Evidence exists that clinical interventions focusing on specific behaviours that promote urine storage and controlled emptying are effective in reducing lower urinary tract symptoms. The concept of women’s toileting behaviour related to urinary elimination has not been well‐developed to guide nursing research and intervention.Data sources.  The CINAHL, Medline, PsycInfo and ISI Citation databases were searched for publications between January, 1960 and May, 2009, using combinations of keywords related to women’s toileting behaviour. Additional publications were identified by examining the reference lists in the papers identified.Review methods.  Johnson’s behavioural system model provided the conceptual framework to identify the concept. Walker and Avant’s method was used for this concept analysis.Results.  Women’s toileting behaviour related to urinary elimination can be defined as voluntary actions related to the physiological event of emptying the bladder, which is comprised of specific attributes including voiding place, voiding time, voiding position and voiding style. This behaviour is also influenced by the physical and social environments.Conclusion.  An explicit definition of women’s toileting behaviour can offer a basis for nurses to understand the factors involved in women’s toileting behaviour. It also facilitates the development of an instrument to assess women’s toileting behaviour better, and to facilitate development of behavioural interventions designed to prevent, eliminate, reduce and manage female lower urinary tract symptoms.
Patients treated with therapeutic hypothermia after cardiac arrest: relatives’ experiences
Authors: Löf Susanna , Sandström Agneta , Engström Åsa 
Published: June 2010

löf s., sandström a. & engström å. (2010) Patients treated with therapeutic hypothermia after cardiac arrest: relatives’ experiences. Journal of Advanced Nursing 66(8), 1760–1768.AbstractTitle.  Patients treated with therapeutic hypothermia after cardiac arrest: relatives’ experiences. Aim.  This paper is a report of a study describing the experiences of relatives when someone they care for survived a cardiac arrest and was treated with therapeutic hypothermia in an intensive care unit.Background.  Witnessing a family member suffering a cardiac arrest is a traumatic event for relatives. Relatives constitute an important support for critically ill patients. It is suggested that therapeutic hypothermia improves the outcome for patients who survive cardiac arrest.Method.  Qualitative personal interviews were conducted during 2009 with eight relatives of patients who had survived cardiac arrest and been treated with therapeutic hypothermia. The interview texts were subjected to qualitative content analysis.Findings.  The analysis resulted in three themes and eight categories. Relatives described the event of the cardiac arrest as frightening. Seeing the patient connected to tubes and equipment induced a feeling of unreality; the patient was experienced as cold, lifeless and hard to recognize. The relatives faced an anxiety‐filled future not knowing what the outcome for their relative would be. Relatives supported each other during this the difficult time, and kept hoping that the patient would survive injury.Conclusion.  Seeing a patient who has had a cardiac arrest and received therapeutic hypothermia is extremely demanding for relatives, as the patient seems to be lifeless. Relatives need to know what is happening on a continual basis during the patient’s entire stay in hospital and even afterwards, and they need to be given opportunities to discuss their own situation and worries.
Health promotion lifestyle profile‐II: Chinese version short form
Authors: Teng Hsiu‐Lan , Yen Miaofen , Fetzer Susan 
Published: June 2010

teng h.‐l., yen m. & fetzer s. (2010) Health promotion lifestyle profile‐II: Chinese version short form. Journal of Advanced Nursing 66(8), 1864–1873.AbstractTitle.  Health promotion lifestyle profile‐II: Chinese version short form. Aim.  This paper is a report of an examination of the validity and reliability of the Chinese version of the Health Promoting Lifestyle Profile.Background.  The Health Promotion Lifestyle Profile, a well‐known instrument measuring health promotion lifestyle behaviours and developed by Walker in 1987 and later refined, has been translated into several languages. The original Chinese translated version, based on Walker’s 48‐item 1987 version, detected six dimensions of health promotion lifestyle behaviours. The 52‐item revised Health Promotion Lifestyle Profile‐II has not been tested for Mandarin‐speakers.Method.  After the English version of the Health Promotion Lifestyle Profile‐II was translated into Chinese using established forward‐backward translation procedures, the psychometric properties of the translated version were determined with 331 Taiwanese Mandarin‐speaking adults. Data were collected from August 2007 to July 2008 at outpatient clinics for health screening in Southern Taiwan. The psychometric properties of the instrument were evaluated, including the internal consistency, test–retest reliability, item analysis and factor analysis.Results.  Neither Walker’s original 6‐factor model nor a forced 6‐factor solution of the 52 items of the Health Promotion Lifestyle Profile‐II was supported. Parallel analysis suggested that five factors be retained, with the 5‐factor solution statistically and conceptually satisfactory. The 5‐factor Chinese version of the Health Promoting Lifestyle Profile explained 53% of the variance in healthy lifestyles. Thirty items were retained for the Chinese version of the Health Promoting Lifestyle Profile.Discussion.  Deletion of 22 items from the Health Promotion Lifestyle Profile‐II did not impair the ability of the Chinese version of the Health Promoting Lifestyle Profile to measure a healthy lifestyle among a sample of Taiwanese adults. The data support the fact that lifestyle is influenced by culture.
Fear of falling in older fallers presenting at emergency departments
Authors: Hill Keith , Womer Makenzie , Russell Melissa , Blackberry Irene , McGann Anne 
Published: June 2010

hill k., womer m., russell m., blackberry i. & mcgann a. (2010) Fear of falling in older fallers presenting at emergency departments. Journal of Advanced Nursing 66(8), 1769–1779.AbstractTitle.  Fear of falling in older fallers presenting at emergency departments. Aim.  This paper is a report of an investigation of fear of falling in older people presenting to emergency departments after a fall.Background.  Falls are a common and disabling cause of attendance at emergency departments. Fear of falling is an often unrecognized consequence of falls that affects older people’s function.Methods.  Sub‐analysis was conducted of a randomized trial of a falls prevention programme for people aged 60 years and older presenting to emergency departments after a fall. Data were collected between 2003 and 2006 with 712 participants recruited (mean age 75, 70% female). Baseline and 12‐month measurements included fear of falling (Modified Falls Efficacy Scale), falls risk, depression, and balance/mobility measures. Intervention participants received interventions based on assessment findings, while control participants received usual care. Repeated measures analysis of variance and logistic regression were used to determine change over time between groups and factors associated with fear of falling, respectively.Results.  Sixty per cent of participants had fear of falling. Statistically significant improvement occurred in overall fear of falling (repeated measures analysis of variance –F = 37·3; P < 0·001) and 13 of 14 sub‐items of the Modified Falls Efficacy Scale at 12 months, but there was no difference between groups. Multivariate logistic regression identified a number of factors associated with statistically significant increased odds of higher fear of falling persisting at12 months, including higher baseline fear of falling and multiple falls in the 12‐month follow‐up.Conclusion.  Nursing staff in emergency departments have an important role in identifying fear of falling, which may guide the need for referral for further assessment and management after discharge from the emergency department.
Association between long working hours and sleep problems in white‐collar workers
Authors: NAKASHIMA MOTOKO , MORIKAWA YUKO , SAKURAI MASARU , NAKAMURA KOSHI , MIURA KATSUYUKI , ISHIZAKI MASAO , KIDO TERUHIKO , NARUSE YUCHI , SUWAZONO YASUSHI , NAKAGAWA HIDEAKI 
Published: June 2010

SummaryThe purpose of this study is to examine the association between long work hours and sleep disturbance among white‐collar workers. We evaluated 1510 male white‐collar full‐time employees, between the ages of 18 and 59 years, using a comprehensive sleep quality questionnaire, the Pittsburgh Sleep Quality Index (PSQI). All subjects worked in a light metal products factory in Japan. The mean number of monthly overtime work hours was determined using data from the previous 6 months from timecard records. Subjects were divided into five groups based on quintiles of the mean number of monthly overtime work hours: <26 h month−1; ≥26 but <40; ≥40 but <50; ≥50 but <63; and >63. Leisure time physical activity, drinking habits just before sleep, presence of family/partner and health status were used as confounding factors in the multiple regression model. The prevalence of short sleep hours, impairment of sleep efficiency and daytime dysfunction among seven components of PSQI increased, in a dose–response relationship, with overtime work hours. The prevalence of high global score (>5.5 points) was highest in workers with overtime hours ≥50 h week−1. The odds ratios after adjustment for confounding factors for high global score using less than 26 h as a reference group were 1.67 for workers with ≥50 h and <63 h, and 1.87 for workers with 63 h and more. To conclude, the present results suggest that long work hours correlate with reduced sleep quality in a dose–response manner.