bluuebunny/crossref_metadata_2025_split huggingface dataset:
Synthèse et étude physico‐chimique de sulfures, sulfoxydes et sulfones en série thiazolique
Authors: Vernin Gaston , Siv Chhan , Metzger Jacques 
Published: April 2009

AbstractL'alkylation des Δ‐4‐thiazolines thiones‐2 dans les conditions de la catalyse biphasique conduit aux thioéthers correspondants avec d'excellents rendements. L'action de l'acide méta chloroperbenzoique sur ces sulfures conduit suivant les conditions expérimentales aux sulfoxydes et sulfones correspondantes avec des rendements de 80 à 90%. Le comportement chromatographique et les caractéristiques spectroscopiques de ces composés sont décrits.
Mass spectral fragmentation pattern of heterocycles part I. 1,4‐Benzoxthians
Authors: Caputo James F. , Martin Arnold R. 
Published: April 2009

AbstractThe mass spectral fragmentation pattern of a series of substituted 1,4‐benzoxathians is reported. The di‐substituted compounds show a characteristic fragment peak at mass 137. This same fragmentation peak is also present in some of the monosubstituted compounds. In the former case the 137 mass peak is quite intense and is the base peak for some of the di‐substituted‐1, 4‐benzoxathians. The mass peak at 137 has been assigned the empirical formula of C7H5OS.
Reactions of 2‐nitro‐2‐(4‐pyridyl) propane with nucleophiles. Substitution at tertiary carbon
Authors: Feuer Henry , Doty James K. , Kornblum Nathan 
Published: April 2009

AbstractThe reaction of 2‐nitro‐2‐(4‐pyridyl) propane (I) with lithium 2‐propanenitronate, lithium cyclohexanenitronate, and sodium thiophenoxide affords excellent yields of the C‐alkylation products 2‐nitro‐3‐(4‐pyridyl)‐2,3‐dimethylbutane (II), 2‐(4‐pyridyl)‐2‐(1‐nitrocyclohexyl) propane (V) and 2‐thiophenyl‐2‐(4‐pyridyl) propane (VI), respectively. In contrast, the reaction of compound I with sodium azide does not afford the expected tertiary azide; but instead gives the dimer 2,3‐bis(4‐pyridyl)‐2,3‐dimethylbutane (III), in near quantitative yield. Evidence has been obtained that all of these transformations proceed via electron transfer pathways.
The facile synthesis of some N‐heleroarylacetic esters
Authors: Iwao Masatomo , Kuraishi Tsukasa 
Published: April 2009

AbstractMethyl and ethyl 2‐quinolylacetate were prepared from quinoline 1‐oxide via acetoacetie ester derivatives. Methyl 2‐quinolyl, 1‐isoquinolyl, 6‐methoxy‐3‐pyridazinyl, 4‐pyridyl and 2‐methyl‐4‐pyridylacetate were synthesized from the corresponding heterocyclic N‐oxides via β‐aminoerotonie ester derivatives.
The reaction of indolizines with tetracyanoethylene
Authors: Ceder Olof , Hall Bengt 
Published: April 2009

AbstractTetracyanoethylene (TCNE) reacts with indolizines (1a‐c) to give mixtures of 1‐ and 3‐sub‐stituted tricyanovinylindolizines, respectively. The isomers are identified by nmr spectroscopy. The occurrence of intramolecular charge‐transfer bands in the visible spectra is discussed.
Structural assignments of 2‐aryl and 3‐arylbenzofurans by carbon‐13 nmr
Authors: Kuo George Y. , Ross Stephen T. 
Published: April 2009

AbstractThe 1–3C chemical shifts of 2‐aryl and 3‐arylbenzofurans are discussed. Pairs of isomers can be differentiated based on the chemical shifts of C‐2 in 3‐arylbenzofurans and C‐3 in 2‐arylbenzofurans. A signal near 100 ppm (101 ± 1.7) indicates a 2‐arylbenzofuran and a signal near (141 ± 1.3) indicates a 3‐arylbenzofuran.
4‐Amino‐6‐hydroxy‐1H‐pyrrolo[3,2‐c] pyridine (3,7‐dideazaisoguanine)
Authors: Schneller S. W. , Hosmane R. S. 
Published: April 2009

AbstractThe preparation of 4‐amino‐6‐hydroxy‐1H‐pyrrolo[3,2‐c]pyridine (3,7‐dideazaisoguanine) (1) in five steps from 1H‐pyrrolo[3,2‐c]pyridin‐4,6(5H,7H) dione (3,7‐dideazaxanthine) (2) is described. Furthermore, prolonged treatment of 1 with 10% aqueous sodium carbonate solution is reported to lead to ring opening of the pyridine of 1 resulting in 3‐carboxamidopyrrole‐2‐acetic acid (3).
Addition d'hétérocycles azotés aux alcynes arylés; synthèse de N‐styrylazoles
Authors: Bourgeois Paul , Lucrece Jacqueline , Dunoguès Jacques 
Published: April 2009

AbstractLes azoles (pyrazoles, imidazoles) se fixent sur la triple liaison du phénylacétylène et du phénylméthylacétylène selon des réactions d'addition, stéréosélectives et stéréospécifiques. Ceci permet la synthèse de divers styrylazoles.
Carbon‐13 nuclear magnetic resonance spectra of methaqualone metabolites
Authors: Brine G. A. , Coleman M. L. , Carroll F. I. 
Published: April 2009

AbstractCarbon‐13 chemical shifts are reported for methaqualone, seven hydroxylated methaqualone metabolites, and four acetate derivatives. The signals are assigned on the basis of chemical shift theory, SFORD multiplicities, signal intensities, and comparisons with model compounds.
Aporphines 24. The synthesis of N‐alkylderivatives of bulbocapnine and isoeorydine
Authors: Elmaleh David R. , Granchelli Felix E. , Neumeyer John L. 
Published: April 2009

AbstractThe synthesis of three new racemic aporphine alkaloids (1b, 1c and 2) is reported and these alkaloids are fully characterized. The method of synthesis involved either a Bischler‐Napieralski‐Psehorr sequence or a Reissert alkylation‐Pschorr cyclization route. The Pschorr cyclization also gave the morphinandienones 7a and 7b, respectively.
[3+2] Cycloaddition nach addition von allylalkohol und allylaminen an 5‐diazourazile
Authors: Romani Sigrun , Schönholzer P. , Klötzer W. 
Published: April 2009

AbstractThe non‐isolable allylalcohol adduct 2c of 5‐diazouracil 1 undergoes intramolecular [3+2] cycloaddition to afford the tricyclic pyrazolofuropyrimidine 3. In a similar way the reaction of the 5‐diazouracils 2, 2a and 2d with allylamine and diallylamine proceeds via the 6‐amino‐adducts to provide the tricyclic pyrazolopyrrolopyrimidines 5, 5a, 7 and 7a. With allylamine and 2a, the 1,2,3‐triazolederivative 6 is obtained as a byproduct.
A new one‐step synthesis of 2,3‐dihydro‐5H‐thiazolo[2,3‐b]quinazolin‐5‐one and 3,4‐dihydro‐2h,6h[1,3]thiazino[2,3‐b] quinazolin‐6‐one
Authors: Payne L. G. , Przytycki J. , Patchett A. A. , Wu M. T. 
Published: April 2009

Abstract2,3‐Dihydro‐5H‐thiazolo[2,3‐b]quinazolin‐5‐one and 3,4‐dihydro‐2H,6H[1,3] thiazino[2,3‐b]‐quinazolin‐6‐one have been synthesized in one step by the reaction of methyl anthranilate with ehloroalkyl isothiocyanates.
Synthèse d'amino‐4 aryl‐3 triazol‐1,2,4 ones‐5
Authors: Milcent René , Redeuilh Catherine 
Published: April 2009

AbstractLa synthèse des arnino‐4 aryl‐3 triazol‐1,2,4 ones‐5 a été réalisée par quatre méthodes: a partir du carbohydrazide par reactions avec les chlorhydrates d'aryliminoéthers, l'orthobenzoate d'éthyle ou le trichlorophénylméthane, et aussi à partir du N‐carbéthoxyhydrazone du benzoate d'éthyle et de ses dérivés par réaction avec l'hydrazine. Les mécanismes de ces reactions sont proposés; ils ont en commun la formation d'un intermédiaire, la monocarbohydrazone du benzoate d'éthyle. Les spectres ir, uv, rmn de ces hétérocycles sont discutés.
A new simple synthesis of 1,4‐benzodiazepines
Authors: Sugasawa T. , Adachi M. , Toyoda T. , Sasakura K. 
Published: April 2009

AbstractA convenient synthesis of 1,4‐benzodiazepines starting from secondary‐2‐aminobenzhydrols, which are easily obtained from secondary anilines and benzaldehydes, is described. 7‐Nitro‐1‐methyl‐1,4‐benzodiazepine 1d can be formed from 5‐nitro‐2‐methylaminomethylacylaminobenzo‐phenone 10b and c by using ammonium carbonate instead of ammonia, which gives only the Smiles‐rearranged product 11.
Application of photoelectron spectroscopy to biologically active molecules and their constituent parts IV. Methylnitroimidazoles
Authors: Kajfež F. , Klasinc L. , Šunjić V. 
Published: April 2009

AbstractPhotoelectron (PE) spectra of imidazole (1), 1‐methylimidazole (2), 2‐methylimidazole (3), 4(5)‐nitroimidazole (4), 2‐methyl‐4(5)nitroimidazole (5), 1,2‐dimethyl‐5‐nitroimidazole (6), 1‐ethyl‐2‐methyl‐5‐nitroimidazole (7), 1‐bromoethyl‐2‐methyl‐5‐nitroimidazole (8) and 1‐hydroxyethyl‐2‐methyl‐5‐nitroimidazole (9) have been recorded using Hel excitation. The electronic structure of the potent antitrichomonal agent 9 is discussed in comparison with compounds 1–8 allowing for the study of the influence of substituents on the imidazole ring.
The insertion and extrusion of heterosulfur bridges. X. Conversions in the triphenylene‐triphenylo[4,5‐bcd] thiophene system
Authors: Klemm L. H. , Lawrence Ross F. 
Published: April 2009

AbstractSulfur bridging of triphenylene (3) to form triphenylo[4,5‐bcd]thiophene (4) is effected in 18% yield by means of hydrogen sulfide and a molybdena catalyst (CMA‐1) at 500°. Compound 4 is purified through its sulfoxide, converted into its sulfone (6), and desulfurized (by means of CMA‐1 plus methanol‐benzene) back to 3. The ultraviolet absorption spectrum of 4 resembles closely that of benzo[e]pyrene. On electron impact 4 shows little skeletal fragmentation, while 6 readily evolves sulfur monoxide and the formyl group.
Synthesis of 4‐aminothieno[2,3‐b] pyridine‐5‐carboxylie acids
Authors: Lalezari Iradj 
Published: April 2009

Abstract2‐Amino‐3‐cyanothiophenes were reacted with ethyl aminocrotonate in the presence of catalytic amounts of p‐toluensulfonic acid. The intermediates 2‐[N‐(3′‐ethoxycarbonyl‐2′‐propenylamino]‐3‐cyanothiophenes obtained were cyclized with sodium ethoxide to give the desired ethyl 4‐aminothieno[2,3‐b] pyridine‐5‐carboxylate. Hydrolysis of the latter aminoesters afforded 4‐aminothieno[2,3‐b]pyridine‐5‐carboxylic acid. The overall yields were about 80%.
Hydrolysis of amides. Electronic effects on kinetics and mechanism of the basic hydrolysis of TV‐substituted benzoylpyrroles
Authors: Cipiciani A. , Linda P. , Savelli G. 
Published: April 2009

AbstractThe hydroxide ion catalyzed hydrolysis of a series of N‐substituted benzoylpyrroles has been studied in water at 25°. Hammett treatment of data shows that substituents affect in a very similar way the rate of formation and of decomposition of the tetrahedral intermediate.
Hydrolysis of amides. Steric effects on kinetics and mechanism of the basic hydrolysis of N‐acylcarbazoles
Authors: Cipiciani A. , Linda P. , Savelli G. 
Published: April 2009

AbstractThe hydroxide ion catalyzed hydrolysis of a series of N‐acylcarbazoles has been studied in water at 25°. Both the rate constants of formation of the tetrahedral intermediate and of its collapse to products are strongly increased by alkyl group branching in the acyl portion.
1,3‐Dipolar cycloadditions of cyclopentadienones with nitrile TV‐oxides
Authors: Argyropoulos N. G. , Alexandrou N. E. 
Published: April 2009

AbstractThe cycloaddition reactions of nitrile oxides with several substituted cyclopentadienones leads to the formation of condensed mono‐isoxazolines (3α,5‐bis‐substituted‐6,6α‐diphenyl‐3αH,4H,6αH‐cyclopenta[2,3‐d]isoxazol‐4‐ones) and in some cases to bis‐isoxazoline derivatives as minor products. The cycloaddition to mono‐adducts is regioselective and only one regioisomer is formed, which can be predicted after consideration of the frontier molecular orbitals of the reacting species. The spectral data of the isoxazolines 3–7 are examined, whereas their structure was fully characterized by X‐ray analysis.
Heterocyclic compounds. XVI . Chemistry of the 1,4,2,3,5,6‐dithiatetrazine ring system
Authors: Weinstein Boris , Hahn Louis T. , Eng Alvin K. 
Published: April 2009

AbstractDerivatives of 1,4,2,3,5,6‐dithiatetrazine‐2,3,5,6‐tetracarboxylate 1,4‐dioxide can be made by reacting 1,2‐dialkyl hydrazinodicarboxylates with thionyl chloride.
Oxidation of aminoindole radical cations
Authors: Bruni P. , Cardellini L. , Fava G. , Tosi G. 
Published: April 2009

AbstractThe varying stabilities of certain aminoindole radical cations toward oxidation with molecular oxygen have been studied. Oxidation leads to different products depending upon the environment around the N‐amino nitrogen. A plausible reaction mechanism is proposed based on electronic and magnetic resonance spectroscopy.
Synthesis and photolysis of doxyl derivatives of 5β‐androstan‐3‐ones
Authors: Smith Douglas L. , Spencer Thomas A. 
Published: April 2009

AbstractIn an unsuccessful attempt to effect remote functionalization at C9, 4,4‐dimethyloxazolidine‐N‐oxyl (doxyl) derivatives at C3 of 5β‐androstan‐3,17‐dione and 5β‐androstan‐17β‐ol‐3‐one were prepared and photolyzed. The former doxyl yielded its C13 stereoisomer; the latter was converted very slowly to intractable material.
Synthesis and stereochemistry of 2‐benzylidene‐4‐carbethoxy‐5‐methyl‐3‐(2H)‐furanones
Authors: Pitta Ivan da Rocha , Lacerda Maria do Socorro , Duc Cuong Luu 
Published: April 2009

AbstractThe title products were obtained by Knoevenagel condensation between 4‐carbethoxy‐5‐methyl‐3‐(2H)furanone and substituted benzaldehydes (or 4‐chloroacetophenone). The configuration of the resulting compounds was investigated by 1H nmr using the lanthanide shift reagent.
A new method for the oxidation of 2‐Keto‐1,2,3,4‐tetrahydro‐quinoxaline, investigations on the complex formed between 2‐hydroxyquinoxaline and cuprous chloride
Authors: Borthakur Naleen , Bhattacharya Alok K. , Prasad Rajendra , Garg Avinash , Rastogi Ramesh C. 
Published: April 2009

Abstract2‐Keto‐1,2,3,4‐tetrahydroquinoxaline I is rapidly oxidised to 2‐hydroxyquinoxaline II on reaction with cupric chloride. This is an oxidation‐reduction reaction in which the cupric chloride in the process is reduced to cuprous chloride. The latter instantaneously reacts with II forming an insoluble brick red complex. Compound II can be regenerated from the complex by treatment with alkali. The properties of this new complex are discussed.
The synthesis of 1‐cyclohexyl‐2‐phenyl‐3‐nitroaziridine and the stereochemistry of cyclization
Authors: Edasery James P. , Cromwell Norman H. 
Published: April 2009

AbstractThe title compound was synthesized by the cyclization of α,β‐dibromonitrostyrene with three moles of cyclohexylamine. Evidence for the steric course of the cyclization reaction is also reported.
Heterocycles from substituted semicarbazides and thionyl chloride. 1‐oxo‐1, 2,3,5‐thiatriazolidin‐4‐one
Authors: Ziman S. D. 
Published: April 2009

AbstractReaction of thionyl chloride and semicarbazides or thiosemicarbazides produces the novel 1‐oxo‐1,2,3,5‐thiatriazolidin‐4‐one or 4‐thione ring system.
A new method for the preparation of 2‐carhoalkoxypyrazolo [5,1 ‐B] quinazolin‐9(1H)ones
Authors: Beam Charles F. , Brown Jane , Dawkins Donna R. , Fives William P. , Fleindel Ned D. 
Published: April 2009

AbstractAnthranilic acid hydrazides were condensed with acetylene diesters, and the intermediate adduets were identified as aeylhydrazones of oxalacetic diester. These anthranilic hydrazones could be thermally cyclized to 2‐carboalkoxypyrazolo[5,1‐b] quinazolin‐9(1H)ones.
Réduction alkylante de quelques composés hétéroaromatiques polyazotés
Authors: Costnao Jean‐Marie , Collision Noéul , Quéaguiner Gay 
Published: April 2009

AbstractLa réduction alkylante de la quinoxaline, de la phlalazine et de la pyrido[2,3‐b] pyrazine, par le tétrahydruroborate de potassium en présence d'acide carboxylique est décrite. Les acides formique, acétique, chloroacétique et n‐propionique sont utilisés, Généralement la réduction et l'alkylation concernent le cycle diazinique du substrat, conduisant au dérivé tétrahydro‐di‐N‐alkylé correspondant. Avec le couple quinoxaline‐acide formique, la réaction de N‐formylation peut devenir prépondérante. L'utilisation de tétradeutérioborate de sodium a permis d'isoler un dérivé héxadeutérié.
A novel reaction of thionyl chloride with 3‐aryl‐2,1‐benzisoxazoles
Authors: Boruah Romesh Chandra , Sandhu J. S. , Thyagarajan G. 
Published: April 2009

AbstractNovel reductive chlorination of 3‐aryl‐2,1‐benzisoxazoles with thionyl chloride is described.The chlorinated aminobenzophenones have been characterised.
Synthesis of some new fluorine‐containing 5‐amino‐1,3‐disubstituted pyrazoles and 1H‐pyrazolo[3,4‐b]pyridines
Authors: Joshi Krishna C. , Pathak Vijai N. , Garg Urmila 
Published: April 2009

AbstractNine new fluorine containing 5‐amino‐1,3‐disubstituted pyrazoles have been synthesized and characterized by spectral studies. Condensation reactions of these 5‐amino‐1,3‐disubstituted pyrazoles with fluorinated 1,3‐diketones in the presence of glacial acetic acid have been studied and the structures of the resulting 1H‐pyrazolo[3,4‐b]pyridines have been confirmed by ir, pmr and 19F nmr spectral studies.
The synthesis of di‐ and tetramethyl substituted macrocyclic polyether‐diester ligands
Authors: Bradshaw Jerald S. , Jolley Scott T. 
Published: April 2009

AbstractThree series of macrocyclic polyether‐diester ligands have been prepared from dimethyl triethylene glycol (20), two dimethyl tetraethylene glycols (21,23), dimethyl pentaethylene glycol (22) and tetramethyl tetraethylene glycol (24) and diglycolyl chloride (products 5–9), thiadiglycolyl chloride (products 10–14) and 2,6‐pyridine dicarbonyl chloride (products 15–19). The eighteen‐membered rings (6 and 16) formed solid potassium thiocyanate complexes. The eighteen‐ and twenty‐one‐membered ring compounds 6–8 and 16–18 complexed with benzylammonium perchlorate in methylene chloride‐d2 as shown by significant chemical shift changes in the 1H nmr spectra.
Condensed pyridazines. Part III. Rearrangement and ring cyclization during the thermolysis of (z)‐methyl 3‐(6‐azido‐3‐chloro‐1‐methyl‐4‐oxo‐1,4‐dihydropyridazin‐5‐yl)‐2‐methylacrylate
Authors: Maeba Isamu , Castle Raymond N. 
Published: April 2009

AbstractThe thermolysis of (Z)‐methyl 3‐(6‐azido‐3‐chloro‐1‐methyl‐4‐oxo‐1,4‐dihydropyridazin‐5‐yl)‐2‐methylacrylate (II) provides a new synthetic route to pyrrolo[2,3‐c‐]pyridazines, specifically, methyl 3‐chloro‐1,6‐dimethyl‐4‐oxo‐1,4‐dihydro‐7H‐pyrrolo[2,3‐c]pyridazine‐5‐carboxylate (III) in 91% yield. Treatment of III with ozone provides an entry into the novel pyridazino[3,4‐d][1,3]oxazine ring system, specifically, 3‐chloro‐1,7‐dimethylpyridazino[3,4‐d][1,3]oxazine‐4,5‐dione (IV) in 73% yield. Compound IV is smoothly hydrolyzed into 6‐acetylamino‐3‐chloro‐1‐methyl‐4‐oxo‐1,4‐dihydropyridazine‐5‐carboxylic acid (V) which is readily recyclized into IV by dehydration with acetic anhydride. Furthermore, IV undergoes a facile reductive ring opening reaction with sodium borohydride to give 3‐chloro‐6‐ethylamino‐1‐methyl‐4‐oxo‐1,4‐dihydropyridazine‐5‐carboxylic acid (VI) in 95% yield.
Ir and pmr spectra of 2‐aryl‐4‐thiazolidinones. III. Stereochemical analysis of 2‐aryl‐3‐(2‐pyridyl)‐4‐thiazolidinones
Authors: Vigorita M. G. , Chimirri A. , Grasso S. , Fenech G. 
Published: April 2009

AbstractThe long‐range coupling through the sulphur atom observed in a number of 2‐aryl‐3‐(2‐pyridyl)‐4‐thiazolidinones suggests that the C2 proton and one of methylene protons are in a cis 1,3 diequatorial relationship. Some additional information concerning the preferred orientations of the substituents in this system are given from Eu(fod)3, [tris(1,1,1,2,2,3,3‐heptafluoro‐7,7‐dimethyloctane‐4,6‐dionato)]europium, induced shift data.
Chemistry of thienopyridines. XXVI. Synthesis of 6‐(γ‐diethylaminopropylamino)thieno[2,3‐b]pyridine
Authors: Klemm L. H. , Bajer Marietta 
Published: April 2009

Abstract6‐(γ‐Diethylaminopropylamino)thieno[2,3‐b]pyridine (3b) was obtained (58% yield) from copper‐promoted aminodechlorination of 6‐chlorothieno[2,3‐b]pyridine at 168°. A mechanistic rationalization for the reaction and the mass spectral fragmentation pattern for 3b are presented.
Carbon‐13 nuclear magnetic resonance spectra of phenycyclidine analogs
Authors: Brine G. A. , Williams E. E. , Boldt K. G. , Carroll F. I. 
Published: April 2009

AbstractNatural abundance carbon‐13 chemical shifts are reported for the hydrochloride salts of phencyclidine (1a) and sixteen analogs. The signals are assigned on the basis of chemical shift theory, SFORD multiplicities, signal intensities, and comparisons with model compounds. In addition to its forensic value, the data suggests that the solution conformations of the analogs are similar to that of phencyclidine hydrochloride.
Selenium heterocycles. XXVIII . Synthesis of pyrrolo[3,2‐d]selenazole and pyrrolo[3,2‐d|thiazole. Two novel heterocycles
Authors: Shafiee A. , Mazloumi A. , Cohen V. I. 
Published: April 2009

AbstractStarting from the readily available 2‐substituted‐4‐formylselenazoles and 2‐substituted‐4‐formylthiazoles, a series of substituted‐pyrrolo[3,2‐d]selenazoles and substituted‐pyrrolo[3,2‐d|‐thiazoles were prepared respectively.
An attempt to convert heterocyclic amines into azides by an aza‐transfer reaction under phase‐transfer reaction conditions
Authors: Stanovnik B. , Tišler M. , Gabrijelčič D. , Kunaver M. , Žmitek J. 
Published: April 2009

AbstractThe conversion of heterocyclic amines into the corresponding azides or tetrazoloazines under phase transfer reaction conditions is described. It was found that this transformation is limited ordy to aminopyridine (1a‐d) aminoisoquinoline (1e) and 2‐aminobenzothiazole (1f) derivatives, while other heterocyclic amines (1g‐w) could not be transformed under these conditions.
A simple one‐step synthesis of 3‐amino‐2,4(1H,3H)quinazolinediones
Authors: Lalezari Iraj , Stein C. A. 
Published: April 2009

AbstractAnthranilic acids and alkyl carbazates in refluxing quinoline give high yields of 3‐arnino‐2,4(1H,3H)‐quinazolinediones.
Acylation reaction of γ,β‐unsaturated β‐keto esters and of ethyl hydrogen malonate. Synthesis of 6‐alkenyl‐5‐ethoxycarbonyl‐2,3‐dihydro‐4H‐pyran‐4‐ones and 4,5‐dioxo‐2,3,7,8‐tetrahydro‐4H,5H‐pyrano[4,3‐b]pyran derivatives
Authors: Chantegrel Bernard , Nadi Abdel‐Ilah , Gelin Suzanne 
Published: April 2009

AbstractThe syntheses of 6‐alkenyl‐5‐ethoxycarbonyl‐2,3‐dihydro‐4H‐pyran‐4‐one derivatives by acylation of γ,β‐unsaturated β‐keto esters or by diacylation of ethyl hydrogen malonate with α,β‐unsaturated acyl chlorides are described. These compounds were converted to 4,5‐dioxo‐2,3,7,8‐tetrahydro‐4H,5H‐pyrano[4,3‐b]pyran derivatives.
The reformatsky reaction of 1‐aryl‐2(1H)pyrimidinones
Authors: Katoh Akira , Omote Yoshimori , Kashima Choji 
Published: April 2009

Abstract1‐Aryl‐2(1H)pyrimidinones I reacted with α‐haloesters in the presence of zinc to give mainly 3,4‐dihydro‐4‐alkoxycarbonylmethyl‐1‐aryl‐2(1H)pyrimidinones IV in addition to the minor products of 3,6‐dihydro‐6‐alkoxycarbonylmethyl‐1‐aryl‐2(1H)pyrimidinones V. Further, 3,4‐dihydro derivatives IVa‐c were successfully converted into the corresponding exomethylene compounds Vla‐c in high yields.
Selenium‐sulfur analogs. 7. Synthesis and characterization of 4‐aralkyl‐1,3‐selenazoles and ‐1,3‐thiazoles
Authors: Hanson Robert N. 
Published: April 2009

AbstractThe diketones 3 and 7 were brominated to give the bromomethyldiketones 4 and 8 which were condensed with selenourea and thiourea to give the corresponding 2‐amino‐1,3‐selenazoles 5a, 9a and 2‐amino‐1,3‐thiazoles 5b, 9b. Reaction with acetic anhydride and benzoic anhydride yielded the 2‐acylated derivatives. Biologic evaluation of these compounds indicated some activity as adrenocortical enzyme inhibitors, but significantly less than that of metyropone.
Synthesis and structure elucidation of 3‐methoxy‐1‐methyl‐1H‐1,2,4,‐triazol‐5‐amine and 5‐methoxy‐1‐methyl‐1H‐1,2,4,‐triazol‐3‐amine
Authors: Selby T. P. , Lepone G. E. 
Published: April 2009

AbstractPreviously it was shown that condensation of dimethyl N‐cyanodithioimidocarbonate (1a) with methylhydrazine gave predominantly 1‐methyl‐5‐methylthio‐1H‐,2,4‐triazol‐3‐amine (2), which was initially identified erroneously as the regioisomer l‐methyl‐3‐methylthio‐1H‐1,2,4‐triazol‐5‐amine (3). We have found that reaction of dimethyl N‐cyanoimidocarbonate (1b) with methyl hydrazine affords a high yield of 3‐methoxy‐1‐methyl‐1H‐1,2,4‐triazol‐5‐amine (4) rather than the regioisomer 5‐methoxy‐1‐methyl‐1H‐1,2,4‐triazol‐3‐amine (5). The structure assignment of 4 was confirmed by X‐ray crystallographic analysis of the benzenesulfonyl isocyanate adduct 7. Triazole 5 was obtained after reacting dimethyl N‐cyanothioimidocarbonate (1c) with methylhydrazine.