Questionnaire-based screening of adolescents and young adult women can identify markers associated with endometriosis
Authors: Chapron Charles , Marcellin Louis , Maitrot-Mantelet Lorraine , Bourdon Mathilde , Maignien Chloé , Parpex Guillaume , Santulli Pietro 
Published: June 2024

Abstract

STUDY QUESTION
Do adolescents and young adult women (YAW) with histologically proven endometriosis present a specific clinical history?

SUMMARY ANSWER
Questionnaire screening of adolescents and YAW can identify clinical markers associated with histologically proven endometriosis.

WHAT IS KNOWN ALREADY
Some validated questionaries can contribute to an earlier endometriosis diagnosis in adults. None of these scores, however, have been validated for adolescents or YAW.

STUDY DESIGN, SIZE, DURATION
This was an observational cross-sectional study using prospectively recorded data performed between January 2005 and January 2020 in a single university tertiary referral centre for endometriosis diagnosis and management. After a thorough surgical examination of the abdomino-pelvic cavity, women with histologically proven endometriosis were allocated to the endometriosis group, and symptomatic women without evidence of endometriosis were allocated to the endometriosis-free control group. The endometriotic patients were allocated into two sub-groups according to their age: adolescent (≤20 years) and YAW (21–24 years).

PARTICIPANTS/MATERIALS, SETTING, METHODS
Adolescents and YAW ≤24 years of age were operated for a symptomatic benign gynaecological condition with signed informed consent. A standardized questionnaire was prospectively completed in the month before the surgery and included epidemiological data, pelvic pain scores, family history of endometriosis, and symptoms experienced during adolescence. The study searched for correlations by univariate analysis to determine clinical markers of endometriosis in adolescents and YAW compared with endometriosis-free control patients.

MAIN RESULTS AND THE ROLE OF CHANCE
Of the 262 study participants, 77 women were adolescents (≤20 years of age) and 185 patients (70.6%) were YAW. The endometriosis group included 118 patients (45.0%) and 144 (55.0%) were assigned to the control group. A family history of endometriosis, absenteeism from school during menstruation, history of fainting spells during menstruation, and prescription of oral contraceptive pills for intense dysmenorrhea were significantly more frequently observed in the endometriotic patients. The prevalence and mean pain scores for dysmenorrhea, deep dyspareunia, non-cyclic chronic pelvic pain and gastrointestinal and lower urinary tract symptoms were significantly greater in the endometriosis group, as was experienced rectal bleeding.

LIMITATIONS, REASONS FOR CAUTION
The study was performed in a single referral centre that treats patients with potentially more severe disease. This questionnaire was evaluated on a population of patients with an indication for endometriosis surgery, which can also select patients with more severe disease. Women with asymptomatic endometriosis were not considered in this study. These factors can affect the external validity of this study.

WIDER IMPLICATIONS OF THE FINDINGS
Patient interviews are relevant to the diagnosis of endometriosis in adolescents and YAW. Combined with imaging and clinical examination, this approach will enable earlier diagnosis and treatment, while remaining non-invasive and rapid.

STUDY FUNDING/COMPETING INTEREST(S)
The study received no funding from external sources. There are no conflicts of interest.

TRIAL REGISTRATION NUMBER
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