bluuebunny/crossref_metadata_2025_split huggingface dataset:
Genetic profile of RHCE, Kell, Duffy, Kidd, Diego and MNS hybrid glycophorins blood groups in ethnic northeastern Thais: Alleles, genotypes and risk of alloimmunisation
Authors: Simtong Piyapong , Jumnainsong Amonrat , Leelayuwat Chanvit 
Published: May 2024

AbstractBackgroundAntibodies against blood group antigens play a key role in the pathophysiology of haemolytic transfusion reactions (HTRs) and haemolytic disease of the fetus and newborn (HDFN). This study aimed to determine the frequencies of alleles, genotypes, and risk of alloimmunisation of clinically significant blood group systems in ethnic northeastern Thais.MethodsIn total, 345 unrelated, healthy, ethnic northeastern Thais were tested using the in‐house PCR‐sequence specific primers (PCR‐SSP) method for simultaneously genotyping of RHCE, Kell, Duffy, Kidd, Diego and MNS glycophorin hybrids and results confirmed by Sanger sequencing.ResultsIn this cohort, the alleles RHCE*C (81.0%) and RHCE*e (84.8%) were more prevalent than RHCE*c (19.0%) and RHCE*E (15.2%). The most common predicted haplotype combinations of the RHCE alleles were C+c‐E−e+(R1R1) (59.4%) followed by the C+c+E+e+ (R1R2) (20.6%) and C+c+E−e+ (R1r) (11.3%). The KEL*01 allele was not found in this study. The frequencies of FY*01 and FY*02 were 88.3% and 11.7%, respectively. The genotype FY*02/02 was found in four samples (1.2%). The frequencies of JK*01 and JK*02 were 52.5% and 47.5%, respectively. Homozygous JK*02/02 was found in 81 samples (23.5%). The frequencies of DI*01 and DI*02 were 0.6% and 99.4%, respectively. In total, 64 samples (18.6%) were found to carry the MNS glycophorin hybrids.ConclusionsOur results indicated a possible high risk of c, E, Fyb, Jka, Jkb and Mia alloimmunisation in these populations. Moreover, methods established for genotyping clinically significant blood groups in this study can now be utilised in routine clinical application.
Phosphate deficiency increases plant susceptibility to Botrytis cinerea infection by inducing the abscisic acid pathway
Authors: Jaskolowski Aime , Poirier Yves 
Published: May 2024

SUMMARYPlants have evolved finely regulated defense systems to counter biotic and abiotic threats. In the natural environment, plants are typically challenged by simultaneous stresses and, amid such conditions, crosstalk between the activated signaling pathways becomes evident, ultimately altering the outcome of the defense response. As an example of combined biotic and abiotic stresses, inorganic phosphate (Pi) deficiency, common in natural and agricultural environments, can occur along with attack by the fungus Botrytis cinerea, a devastating necrotrophic generalist pathogen responsible for massive crop losses. We report that Pi deficiency in Arabidopsis thaliana increases its susceptibility to infection by B. cinerea by influencing the early stages of pathogen infection, namely spore adhesion and germination on the leaf surface. Remarkably, Pi‐deficient plants are more susceptible to B. cinerea despite displaying the appropriate activation of the jasmonic acid and ethylene signaling pathways, as well as producing secondary defense metabolites and reactive oxygen species. Conversely, the callose deposition in response to B. cinerea infection is compromised under Pi‐deficient conditions. The levels of abscisic acid (ABA) are increased in Pi‐deficient plants, and the heightened susceptibility to B. cinerea observed under Pi deficiency can be reverted by blocking ABA biosynthesis. Furthermore, high level of leaf ABA induced by overexpression of NCED6 in Pi‐sufficient plants also resulted in greater susceptibility to B. cinerea infection associated with increased spore adhesion and germination, and reduced callose deposition. Our findings reveal a link between the enhanced accumulation of ABA induced by Pi deficiency and an increased sensitivity to B. cinerea infection.
Internet linkage and international trade: From the perspective of risk alleviation
Authors: Duan Jie , Hu Zengxi 
Published: May 2024

AbstractExtensive research has studied the effect of the Internet on trade, yet little is known about its role in trade facilitation through risk alleviation. This research investigates how Internet linkage facilitates exports, particularly through the novel channel of risk alleviation. Theoretically, this paper introduces a gravity model augmented with export risk to establish the stimulating effect of Internet linkage on exports. Empirically, this paper uses inter‐domain hyperlinks as a proxy for Internet linkage in 2009, uncovering a statistically significant positive impact of Internet linkage on exports. Notably, there is a 27.8% increase in exports in reaction to a doubling of the Internet linkage intensity. By employing various techniques, we meticulously address potential endogeneity issues and substantiate the risk‐alleviation mechanism at both the country and product levels. Particularly, we find that exports to riskier countries and of riskier products benefit more from the Internet linkage. This study sheds new light on the novel channel through which the Internet promotes exports, enriching the existing literature in this field.
Invertible topological field theories
Authors: Schommer‐Pries Christopher 
Published: May 2024

AbstractA ‐dimensional invertible topological field theory (TFT) is a functor from the symmetric monoidal ‐category of ‐bordisms (embedded into and equipped with a tangential ‐structure) that lands in the Picard subcategory of the target symmetric monoidal ‐category. We classify these field theories in terms of the cohomology of the ‐connective cover of the Madsen–Tillmann spectrum. This is accomplished by identifying the classifying space of the ‐category of bordisms with as an ‐space. This generalizes the celebrated result of Galatius–Madsen–Tillmann–Weiss (Acta Math. 202 (2009), no. 2, 195–239) in the case , and of Bökstedt–Madsen (An alpine expedition through algebraic topology, vol. 617, Contemp. Math., Amer. Math. Soc., Providence, RI, 2014, pp. 39–80) in the ‐uple case. We also obtain results for the ‐category of ‐bordisms embedding into a fixed ambient manifold , generalizing results of Randal–Williams (Int. Math. Res. Not. IMRN 2011 (2011), no. 3, 572–608) in the case . We give two applications: (1) we completely compute all extended and partially extended invertible TFTs with target a certain category of ‐vector spaces (for ), and (2) we use this to give a negative answer to a question raised by Gilmer and Masbaum (Forum Math. 25 (2013), no. 5, 1067–1106. arXiv:0912.4706).
Exercise‐induced changes in left ventricular strain are affected by interleukin‐6 activity: An exploratory analysis of a randomised‐controlled trial in humans with abdominal obesity
Authors: Jønck Simon , Løk Mathilde , Durrer Cody , Wedell‐Neergaard Anne‐Sophie , Lehrskov Louise Lang , Legaard Grit Elster , Krogh‐Madsen Rikke , Rosenmeier Jaya , Lund Morten Asp Vonsild , Pedersen Bente Klarlund , Ellingsgaard Helga , Berg Ronan M. G. , Christensen Regitse Højgaard 
Published: May 2024

AbstractWhilst the exercise‐induced myokine interleukin‐6 (IL‐6) plays a beneficial role in cardiac structural adaptations, its influence on exercise‐induced functional cardiac outcomes remains unknown. We hypothesised that IL‐6 activity is required for exercise‐induced improvements in left ventricular global longitudinal strain (LV GLS). In an exploratory study 52 individuals with abdominal obesity were randomised to 12 weeks’ high‐intensity exercise or no exercise in combination with IL‐6 receptor inhibition (IL‐6i) or placebo. LV strain and volume measurements were assessed by cardiac magnetic resonance. Exercise improved LV GLS by −5.4% [95% CI: −9.1% to −1.6%] (P = 0.007). Comparing the change from baseline in LV GLS in the exercise + placebo group (−4.8% [95% CI: −7.4% to −2.2%]; P < 0.0004) to the exercise + IL‐6i group (−1.1% [95% CI: −3.8% to 1.6%]; P = 0.42), the exercise + placebo group changed −3.7% [95% CI: −7.4% to −0.02%] (P = 0.049) more than the exercise + IL6i group. However, the interaction effect between exercise and IL‐6i was insignificant (4.5% [95% CI: −0.8% to 9.9%]; P = 0.09). Similarly, the exercise + placebo group improved LV global circumferential strain by −3.1% [95% CI: −6.0% to −0.1%] (P = 0.04) more compared to the exercise + IL‐6i group, yet we found an insignificant interaction between exercise and IL‐6i (4.2% [95% CI: −1.8% to 10.3%]; P = 0.16). There was no effect of IL‐6i on exercise‐induced changes to volume rates. This study underscores the importance of IL‐6 in improving LV GLS in individuals with abdominal obesity suggesting a role for IL‐6 in cardiac functional exercise adaptations.
Research on Fatigue Stress Reconstruction of Major Equipment Based on Neural Network
Authors: Yang Bowen , Yang Chenxu , Li Hua , Yang Fan , Gao Jian , Huo Junzhou 
Published: May 2024

Abstract
This article first proposes a stress/strain reconstruction method based on neural networks. The construction of the dataset and the setting of the network structure are introduced around this method. Standard component strain reconstruction experiments are carried out to verify the method, and the error between the reconstructed values and the measured values is within 15%. This article further takes the tunnel boring machine (TBM) disk cutter shaft as the research object, extracts the coordinate load stress dataset of dangerous positions through finite element method, trains and tests the stress reconstruction model, and the error between the reconstruction value and the simulation value is within 10%. Finally, this article utilized a stress reconstruction model to reconstruct the stress time history of the dangerous position of the TBM rolling cutter shaft and evaluated the fatigue life of the cutter shaft based on various life criteria.
VEXAS syndrome diagnosis starting from ultrasound findings: a case report
Authors: Rácz Tamás , Burciu Sergiu , Torok Tunde , Damian Laura , Rednic Simona , Simon Siao-Pin 
Published: May 2024

VEXAS syndrome is a recently described condition characterized by systemic inflammation, predisposition to hematologic malignancy and a high rate of venous thrombosis. Here we report the case of an elderly male with erythema nodosumlike lesions, ankle arthralgia, and general symptoms. B-mode and Doppler ultrasound of the subcutis diagnosed superficial thrombophlebitis of the lower limbs, which turned out to be the manifestation of a paucisymptomatic VEXAS syndrome. VEXAS should be considered in any patient who presents with unexplained superficial thrombophlebitis, macrocytic anemia and unexplained systemic inflammation.
Barriers and facilitators of implementing a multicomponent intervention to improve faecal immunochemical test (FIT) colorectal cancer screening in primary care clinics, Alberta
Authors: Adhikari Kamala , Mah Sharon S , Patterson Michelle , Teare Gary F , Manalili Kimberly 
Published: May 2024

Background and objectiveColorectal cancer (CRC) screening is effective at reducing the incidence and mortality of CRC. To address suboptimal CRC screening rates, a faecal immunochemical test (FIT) multicomponent intervention was piloted in four urban multidisciplinary primary care clinics in Alberta from September 2021 to April 2022. The interventions included in-clinic distribution of FIT kits, along with FIT-related patient education and follow-up. This study explored barriers and facilitators to implementing the intervention in four primary clinics using the Consolidated Framework for Implementation Research (CFIR).MethodsIn-depth qualitative semistructured key informant interviews, guided by the CFIR, were conducted with 14 participants to understand barriers and facilitators of the FIT intervention implementation. Key informants were physicians, quality improvement facilitators and clinical staff. Interviews were analysed following an inductive–deductive approach. Implementation barriers and facilitators were organised and interpreted using the CFIR to facilitate the identification of strategies to mitigate barriers and leverage facilitators for implementation at the clinic level.ResultsKey implementation facilitators reported by participants were patient perceived needs being met; the clinics’ readiness to implement FIT, including staff’s motivation, skills, knowledge, and resources to implement; intervention characteristics—evidence-based, adaptable and compatible with existing workflows; regular staff communications; and use of the electronic medical record (EMR) system. Key barriers to implementation were patient’s limited awareness of FIT screening for CRC and discomfort with stool sample collection; the impacts of COVID-19 (patients missed appointment, staff coordination and communication were limited due to remote work); and limited clinic capacity (knowledge and skills using EMR system, staff turnover and shortage).ConclusionFindings from the study facilitate the refinement and adaption of future FIT intervention implementation. Future research will explore implementation barriers and facilitators in rural settings and from patients’ perspectives to enhance the spread and scale of the intervention.
Implementation of Agile in healthcare: methodology for a multisite home hospital accelerator
Authors: Desai Meghna , Tardif-Douglin Miriam , Miller Indigo , Blitzer Stephanie , Gardner David L , Thompson Teresa , Edmondson LaPonda , Levine David M 
Published: May 2024

BackgroundThe diffusion of innovation in healthcare is sluggish. Evidence-based care models and interventions take years to reach patients. We believe the healthcare community could deliver innovation to the bedside faster if it followed other sectors by employing an organisational framework for efficiently accomplishing work. Home hospital is an example of sluggish diffusion. This model provides hospital-level care in a patient’s home instead of in a traditional hospital with equal or better outcomes. Home hospital uptake has steadily grown during the COVID-19 pandemic, yet barriers to launch remain for healthcare organisations, including access to expertise and implementation tools. The Home Hospital Early Adopters Accelerator was created to bring together a network of healthcare organisations to develop tools necessary for programme implementation.MethodsThe accelerator used the Agile framework known as Scrum to rapidly coordinate work across many different specialised skill sets and blend individuals who had no experience with one another into efficient teams. Its goal was to take 40 weeks to develop 20 ‘knowledge products’,or tools critical to the development of a home hospital programme such as workflows, inclusion criteria and protocols. We conducted a mixed-methods evaluation of the accelerator’s implementation, measuring teams’ productivity and experience.Results18 healthcare organisations participated in the accelerator to produce the expected 20 knowledge products in only 32 working weeks, a 20% reduction in time. Nearly all (97.4%) participants agreed or strongly agreed the Scrum teams worked well together, and 96.8% felt the teams produced a high-quality product. Participants consistently remarked that the Scrum team developed products much faster than their respective organisational teams. The accelerator was not a panacea: it was challenging for some participants to become familiar with the Scrum framework and some participants struggled with balancing participation in the Accelerator with their job duties.ConclusionsImplementation of an Agile-based accelerator that joined disparate healthcare organisations into teams equipped to create knowledge products for home hospitals proved both efficient and effective. We demonstrate that implementing an organisational framework to accomplish work is a valuable approach that may be transformative for the sector.
Association between the frontoparietal network, clinical symptoms and treatment response in individuals with untreated anorexia nervosa
Authors: He Qianqian , Zheng Hui , Zhang Jialin , Yue Ling , Kang Qing , Lian Cheng , Guo Lei , Chen Yan , Hu Yanran , Wang Yuping , Peng Sufang , Wang Zhen , Liu Qiang , Chen Jue 
Published: May 2024

BackgroundAnorexia nervosa (AN) has been characterised as a psychiatric disorder associated with increased control. Currently, it remains difficult to predict treatment response in patients with AN. Their cognitive abilities are known to be resistant to treatment. It has been established that the frontoparietal control network (FPCN) is the direct counterpart of the executive control network. Therefore, the resting-state brain activity of the FPCN may serve as a biomarker to predict treatment response in AN.AimsThe study aimed to investigate the association between resting-state functional connectivity (RSFC) of the FPCN, clinical symptoms and treatment response in patients with AN.MethodsIn this case-control study, 79 female patients with AN and no prior treatment from the Shanghai Mental Health Center and 40 matched healthy controls (HCs) were recruited from January 2015 to March 2022. All participants completed the Questionnaire Version of the Eating Disorder Examination (version 6.0) to assess the severity of their eating disorder symptoms. Additionally, RSFC data were obtained from all participants at baseline by functional magnetic resonance imaging. Patients with AN underwent routine outpatient treatment at the 4th and 12th week, during which time their clinical symptoms were evaluated using the same measures as at baseline.ResultsAmong the 79 patients, 40 completed the 4-week follow-up and 35 completed the 12-week follow-up. The RSFC from the right posterior parietal cortex (PPC) and dorsolateral prefrontal cortex (dlPFC) increased in 79 patients with AN vs 40 HCs after controlling for depression and anxiety symptoms. By multiple linear regression, the RSFC of the PPC to the inferior frontal gyrus was found to be a significant factor for self-reported eating disorder symptoms at baseline and the treatment response to cognitive preoccupations about eating and body image, after controlling for age, age of onset and body mass index. The RSFC in the dlPFC to the middle temporal gyrus and the superior frontal gyrus may be significant factors in the treatment response to binge eating and loss of control/overeating in patients with AN.ConclusionsAlterations in RSFC in the FPCN appear to affect self-reported eating disorder symptoms and treatment response in patients with AN. Our findings offer new insight into the pathogenesis of AN and could promote early prevention and treatment.
Association of initial assessment variables and mortality in severe pediatric traumatic brain injury
Authors: Bergus Katherine C , Patterson Kelli N , Asti Lindsey , Bricker Josh , Beyene Tariku J , Schulz Lauren N , Schwartz Dana M , Thakkar Rajan K , Sribnick Eric A 
Published: May 2024

BackgroundPredictive scales have been used to prognosticate long-term outcomes of traumatic brain injury (TBI), but gaps remain in predicting mortality using initial trauma resuscitation data. We sought to evaluate the association of clinical variables collected during the initial resuscitation of intubated pediatric severe patients with TBI with in-hospital mortality.MethodsIntubated pediatric trauma patients <18 years with severe TBI (Glasgow coma scale (GCS) score ≤8) from January 2011 to December 2020 were included. Associations between initial trauma resuscitation variables (temperature, pulse, mean arterial blood pressure, GCS score, hemoglobin, international normalized ratio (INR), platelet count, oxygen saturation, end tidal carbon dioxide, blood glucose and pupillary response) and mortality were evaluated with multivariable logistic regression.ResultsAmong 314 patients, median age was 5.5 years (interquartile range (IQR): 2.2–12.8), GCS score was 3 (IQR: 3–6), Head Abbreviated Injury Score (hAIS) was 4 (IQR: 3-5), and most had a severe (25-49) Injury Severity Score (ISS) (48.7%, 153/314). Overall mortality was 26.8%. GCS score, hAIS, ISS, INR, platelet count, and blood glucose were associated with in-hospital mortality (allp<0.05). As age and GCS score increased, the odds of mortality decreased. Each 1-point increase in GCS score was associated with a 35% decrease in odds of mortality. As hAIS, INR, and blood glucose increased, the odds of mortality increased. With each 1.0 unit increase in INR, the odds of mortality increased by 1427%.ConclusionsPediatric patients with severe TBI are at substantial risk for in-hospital mortality. Studies are needed to examine whether earlier interventions targeting specific parameters of INR and blood glucose impact mortality.
Case 325: Persistent Craniopharyngeal Canal
Authors: Suthar Pokhraj Prakashchandra , Nagarajan Murali , Bhabad Sudeep 
Published: May 2024

History A 76-year-old female patient with a history of rheumatoid arthritis, Sjögren syndrome, and hypertension presented with headache, fever, and dysphagia. The patient was taking prednisone and leflunomide to treat rheumatoid arthritis. The headache was primarily left sided and occasionally radiated to the occipital region. The patient had a high-grade fever spike, with a temperature of 104 °F (40 °C). Results of a prior lumbar puncture and temporal artery biopsy from an outside hospital were negative. Findings of a neurologic examination were unremarkable. Oropharyngeal examination for dysphagia revealed minimal pharyngeal motility, with pooling of food in the pharynx, which was thought to be due to cranial nerve dysfunction. Laboratory analysis revealed that, except for anemia, complete blood count parameters were within normal limits. C-reactive protein level (49.7 mg/L; reference range, 0.0–8.0 mg/L), erythrocyte sedimentation rate (>140 mm/h with Westergren method; reference range, 0–27 mm/h), and brain-type natriuretic peptide level (145 pg/mL; reference range, 0–100 pg/mL) were elevated. Blood and urine cultures were negative. A lumbar puncture was performed, which revealed cloudy cerebrospinal fluid (CSF), with an elevated CSF protein level (78 mg/dL; reference range, 7.0–35.0 mg/dL) and a low CSF glucose level (37 mg/dL [2.05 mmol/L]; reference range, 45–70 mg/dL [2.50–3.89 mmol/L]); otherwise, CSF encephalopathy, an autoimmune panel, and cultures were negative. CT and MRI of the brain with paranasal sinus were performed. Nasal endoscopy-guided drainage of the preclival fluid collection was performed, and biopsy of nasopharyngeal tissue was performed. Fluid culture revealed the growth of Candida albicans, as well as Pseudomonas and Enterobacter aerogenes. The patient received fluconazole, ceftriaxone, vancomycin, and metronidazole. Follow-up MRI was performed after 2 weeks.