bluuebunny/crossref_metadata_2025_split huggingface dataset:
Holographic reflected entropy and islands in interface CFTs
Authors: Basak Jaydeep Kumar , Basu Debarshi , Malvimat Vinay , Parihar Himanshu , Sengupta Gautam 
Published: May 2024

Abstract
We investigate the reflected entropy for various mixed state configurations in the two dimensional holographic conformal field theories sharing a common interface (ICFTs). In the AdS3/ICFT2 framework, we compute the holographic reflected entropy for the required configurations in the vacuum state of the ICFT2 which is given by twice the entanglement wedge cross section (EWCS) in a spacetime involving two AdS3 geometries glued along a thin interface brane. Subsequently, we evaluate the EWCS in the bulk geometry involving eternal BTZ black strings with an AdS2 interface brane, which is dual to an ICFT2 in the thermofield double (TFD) state. We explore the system from a doubly holographic perspective and determine the island contributions to the reflected entropy in the two dimensional semi-classical description involving two CFT2s coupled to an AdS2 brane. We demonstrate that the results from the island formula match precisely with the bulk AdS3 results in the large tension limit of the interface brane. We illustrate that the phase structure of the reflected entropy is quite rich involving many novel induced island phases and demonstrate that it obeys the expected Page curve for the reflected entropy in a radiation bath coupled to the AdS2 black hole.
w1+∞ and Carrollian holography
Authors: Saha Amartya 
Published: May 2024

Abstract
In a 1 + 2D Carrollian conformal field theory, the Ward identities of the two local fields $$ {S}_0^{+} $$

S
0
+

and $$ {S}_1^{+} $$

S
1
+

, entirely built out of the Carrollian conformal stress-tensor, contain respectively up to the leading and the subleading positive helicity soft graviton theorems in the 1 + 3D asymptotically flat space-time. This work investigates how the subsubleading soft graviton theorem can be encoded into the Ward identity of a Carrollian conformal field $$ {S}_2^{+} $$

S
2
+

. The operator product expansion (OPE) $$ {S}_2^{+}{S}_2^{+} $$

S
2
+

S
2
+

is constructed using general Carrollian conformal symmetry principles and the OPE commutativity property, under the assumption that any time-independent, non-Identity field that is mutually local with $$ {S}_0^{+} $$

S
0
+

, $$ {S}_1^{+} $$

S
1
+

, $$ {S}_2^{+} $$

S
2
+

has positive Carrollian scaling dimension. It is found that, for this OPE to be consistent, another local field $$ {S}_3^{+} $$

S
3
+

must automatically exist in the theory. The presence of an infinite tower of local fields $$ {S}_{k\ge 3}^{+} $$

S

k
≥
3

+

is then revealed iteratively as a consistency condition for the $$ {S}_2^{+}{S}_{k-1}^{+} $$

S
2
+

S

k
−
1

+

OPE. The general $$ {S}_k^{+}{S}_l^{+} $$

S
k
+

S
l
+

OPE is similarly obtained and the symmetry algebra manifest in this OPE is found to be the Kac-Moody algebra of the wedge sub-algebra of w1+∞. The Carrollian time-coordinate plays the central role in this purely holographic construction. The 2D Celestial conformally soft graviton primary $$ {H}^k\left(z,\overline{z}\right) $$

H
k

z

z
¯

is realized to be contained in the Carrollian conformal primary $$ {S}_{1-k}^{+}\left(t,z,\overline{z}\right) $$

S

1
−
k

+

t
z

z
¯

. Finally, the existence of the infinite tower of fields $$ {S}_k^{+} $$

S
k
+

is shown to be directly related to an infinity of positive helicity soft graviton theorems.
Secondary massive quarks with the Mellin-Barnes expansion
Authors: Bris Alejandro , Mateu Vicent 
Published: May 2024

Abstract
Processes involving only massless or massive quarks at tree-level get corrections from massive (lighter, heavier, or equal-mass) secondary quarks starting at two-loop order, generated by a virtual gluon splitting into a massive quark anti-quark pair. One convenient approach to compute such two-loop corrections is starting with the one-loop diagram considering the virtual gluon massive. Carrying out a dispersive integral with a suitable kernel over the gluon mass yields the desired two-loop result. On the other hand, the Mellin-Barnes representation can be used to compute the expansion of Feynman integrals in powers of a small parameter. In this article we show how to combine these two ideas to obtain the corresponding expansions for large and small secondary quark masses to arbitrarily high orders in a straightforward manner. Furthermore, the convergence radius of both expansions can be shown to overlap, being each series rapidly convergent. The advantage of our method is that the Mellin representation is obtained directly for the full matrix element from the same one-loop computation one needs in large-β0 computations, therefore many existing results can be recycled. With minimal modifications, the strategy can be applied to compute the expansion of the one-loop correction coming from a massive gauge boson. We apply this method to a plethora of examples, in particular those relevant for factorized cross sections involving massless and massive jets, recovering known results and obtaining new ones. Another bonus of our approach is that, postponing the Mellin inversion, one can obtain the small- and large-mas expansions for the RG-evolved jet functions. In many cases, the series can be summed up yielding closed expressions.
Can quantum statistics help distinguish Dirac from Majorana neutrinos?
Authors: Akhmedov Evgeny , Trautner Andreas 
Published: May 2024

Abstract
Finding out if neutrinos are Dirac or Majorana particles is known to be extremely difficult due to the smallness of neutrino mass and the fact that in the limit mν = 0 both Dirac and Majorana neutrinos become Weyl fermions, i.e. are indistinguishable. There have been suggestions in the literature that in the case of processes with production of a neutrino-antineutrino pair (if neutrinos are Dirac particles) or two neutrinos (if they are of Majorana nature) quantum statistics may be of help. This is because for Majorana neutrinos quantum indistinguishability of identical particles requires the amplitude of the process to be antisymmetrized with respect to the interchange of the final-state neutrinos, whereas no such antisymmetrization must be done for Dirac neutrinos. It has been claimed that the resulting differences between the cross sections for Dirac and Majorana neutrinos persist even for arbitrarily small but not exactly vanishing neutrino mass. We demonstrate that, at least in the framework of the Standard Model, this is not the case. We also give a general proof that within the Standard Model quantum statistics does not help tell Dirac and Majorana neutrinos apart in the limit of negligibly small mν/E.
Non-hydrodynamic response in QCD-like plasma
Authors: Ke Weiyao , Yin Yi 
Published: May 2024

Abstract
Quark-gluon plasma’s (QGP) properties at non-hydrodynamic and non-perturbative regimes remain largely unexplored. Here, we examine the response functions describing how a QGP-like plasma responds to initial energy-momentum disturbance in both static and Bjorken-expanding plasma at non-hydrodynamic gradient using the Boltzmann equation in the relaxation-time approximation (RTA). We show that the resulting response functions are remarkably similar in both static and expanding backgrounds at non-hydrodynamic gradients. While non-hydrodynamic response can not be described by the conventional first-order and second-order theories, its behavior is reasonably captured by the extended version of hydrodynamics proposed by us [1]. The potential sensitivity of the Euclidean correlator to non-hydrodynamic response is also illustrated.
Circular RNAs in EMT-driven metastasis regulation: modulation of cancer cell plasticity, tumorigenesis and therapy resistance
Authors: Ashrafizadeh Milad , Dai Jingyuan , Torabian Pedram , Nabavi Noushin , Aref Amir Reza , Aljabali Alaa A. A. , Tambuwala Murtaza , Zhu Minglin 
Published: May 2024

AbstractThe non-coding RNAs comprise a large part of human genome lack of capacity in encoding functional proteins. Among various members of non-coding RNAs, the circular RNAs (circRNAs) have been of importance in the pathogenesis of human diseases, especially cancer. The circRNAs have a unique closed loop structure and due to their stability, they are potential diagnostic and prognostic factors in cancer. The increasing evidences have highlighted the role of circRNAs in the modulation of proliferation and metastasis of cancer cells. On the other hand, metastasis has been responsible for up to 90% of cancer-related deaths in patients, requiring more investigation regarding the underlying mechanisms modulating this mechanism. EMT enhances metastasis and invasion of tumor cells, and can trigger resistance to therapy. The cells demonstrate dynamic changes during EMT including transformation from epithelial phenotype into mesenchymal phenotype and increase in N-cadherin and vimentin levels. The process of EMT is reversible and its reprogramming can disrupt the progression of tumor cells. The aim of current review is to understanding the interaction of circRNAs and EMT in human cancers and such interaction is beyond the regulation of cancer metastasis and can affect the response of tumor cells to chemotherapy and radiotherapy. The onco-suppressor circRNAs inhibit EMT, while the tumor-promoting circRNAs mediate EMT for acceleration of carcinogenesis. Moreover, the EMT-inducing transcription factors can be controlled by circRNAs in different human tumors.
Candida albicans ergosterol disorders as a consequence of the new sulfone derivative action mode
Authors: Staniszewska Monika , Kazek Michalina , Rogalska Marta , Wojewódzka Anna , Kuryk Łukasz , Ochal Zbigniew 
Published: May 2024

AbstractA series of novel sulfone derivatives were synthesized and screened in vitro for their cytotoxicity and antifungal activity with annotated primary mechanism of action (MOA). We prioritized sulfones with high (4-(bromodichloromethylsulfonyl)benzoic acid 4, 4-(difluoromethylsulfonyl)benzoic acid 12), little (3-[4-(bromodichloromethylsulfonyl)phenyl]propanoic acid 8, difluoromethyl 4-methylphenyl sulfone 11, 4-(difluoromethylsulfonyl)benzoic acid 12), or no cytotoxicity of 4-(4-(dichloromethylsulfonyl)benzoic acid 3) and 3-[4-(dichloromethylsulfonyl)phenyl]propanoic acid 7 against mammalian cell lines. 3 was found to be the most potent sulfone against Candida albicans (Rlog=7.25 at 128–256 µg/mL). The mutation in the CNB1 gene (1) increased the sensitivity of the C. albicans biofilm to 3; (2) reduced ergosterol production and therefore generated higher susceptibility to 4. Sulfone 4 at 128 µg/mL increased cellular RH-123 fluorescence in the wild-type cells of C. albicans, except CNB1/cnb1∆. Moreover, the uptake of sulfones into the cell was unaffected regardless of the presence or absence of RH-123, and the uptake of sulfones was strictly cell/strain dependent. Both RH123 and sulfones cumulatively competed with one another for access to transporters. Calcineurin played a role in this mechanism.
Topology optimization of broadband acoustic transition section: a comparison between deterministic and stochastic approaches
Authors: Mousavi Abbas , Uihlein Andrian , Pflug Lukas , Wadbro Eddie 
Published: May 2024

AbstractThis paper focuses on the topology optimization of a broadband acoustic transition section that connects two cylindrical waveguides with different radii. The primary objective is to design a transition section that maximizes the transmission of a planar acoustic wave while ensuring that the transmitted wave exhibits a planar shape. Helmholtz equation is used to model linear wave propagation in the device. We utilize the finite element method to solve the state equation on a structured mesh of square elements. Subsequently, a material distribution topology optimization problem is formulated to optimize the distribution of sound-hard material in the transition section. We employ two different gradient-based approaches to solve the optimization problem: namely, a deterministic approach using the method of moving asymptotes (MMA), and a stochastic approach utilizing both stochastic gradient (SG) and continuous stochastic gradient (CSG) methods. A comparative analysis is provided among these methodologies concerning the design feasibility and the transmission performance of the optimized designs, and the computational efficiency. The outcomes highlight the effectiveness of stochastic techniques in achieving enhanced broadband acoustic performance with reduced computational demands and improved design practicality. The insights from this investigation demonstrate the potential of stochastic approaches in acoustic applications, especially when broadband acoustic performance is desired.
Inducing hydrophobicity in stainless steel 304 by mechanical texturing and chemical functionalization
Authors: Nanou Paraskevi , Zarkadoulas Athanasios , Pandis Pavlos K. , Tsilikas Ioannis , Katis Ilias , Almpani Despoina , Orfanoudakis Nikolaos , Vourdas Nikolaos , Stathopoulos Vassilis 
Published: May 2024

AbstractThis study investigates the impact of combined texturing by micromachining and chemical functionalization on the wetting behavior and water condensation on stainless steel 304. The transition from Wenzel to Cassie-Baxter or impregnated Cassie-Baxter regimes is investigated. Understanding this transition is critical for advancing surface engineering, as it enables precise control over wetting behavior for various applications. Herein, we report on the wire EDM (wEDM) machining on stainless steel 304 to produce two distinct microstructure patterns with directional canals or pyramidal structure, and their performance in water condensation. These patterns significantly impact water condensation performance. wEDM is employed to create surface roughness, followed by phosphoric acid treatment and chemical functionalization with trichloro-1H,1H,2H,2H-perfluorooctyl silane. Contact angle measurements reveal a synergistic effect between groove direction and silane coating, leading to hydrophobic surfaces and dropwise water condensation. Specimens with directional canals exhibit a contact angle of 150°, while specimens with pyramidal structures exhibit 151o. Roll-off angle experiments showcased distinct behavior among specimens featuring canals or pyramidal structures. Specimens with canals exhibit notably lower roll-off angles compared to both flat surfaces and those with pyramidal patterns, leading to a dependence of roll-off angles on the orientation of canals. In humid environments, micromachined specimens exhibit superior water condensation capability compared to untreated SS304 surfaces. Chemically functionalized grooved specimens present larger condensate droplet diameters than flat surfaces. An enhancement in water condensation and a sevenfold higher latent heat transfer coefficient is reported. Specimens with chemical functionalization achieve corrosion protection with an efficiency reaching 82.9%.
Toward cleaner space explorations: a comparative life cycle assessment of spacecraft propeller tank manufacturing technologies
Authors: Kokare Samruddha , Moraes Luis , Fernandes Nuno , Norman Andrew , Godina Radu 
Published: May 2024

AbstractThe traditional method of manufacturing propellant tanks for rockets and spaceships involves significant amounts of forging, and machining, making it expensive and environmentally unfriendly. A novel approach for manufacturing propellant tanks that reduces the need for machining and friction stir welding processes has been presented in this paper. This approach involves manufacturing a tank half starting from a single metal plate, using innovative and advanced metal forming processes such as hot stretch forming, magnetic pulse forming, hub forming, and integrated stiffened cylinder (ISC) flow forming followed by orbital welding of two tank halves. A life cycle assessment (LCA) study was conducted in accordance with ISO 14044:2006 standard using the ReCiPe 2016 Midpoint (H) method to compare the environmental impacts of the traditional and newly developed approaches for manufacturing propellant tanks. The results of the LCA study showed that the new approach based on advanced forming technologies reduced carbon footprint by 40%, cumulative energy demand by 35%, water footprint by 17%, and materials waste by 4% compared to traditional manufacturing. The lower environmental impact of the new approach was attributed to a decrease in friction stir welding requirements due to the implementation of advanced forming techniques that enable integrated tank production. This lowered the overall energy consumption in the novel approach by a factor of 1.5 and in turn resulted in lower environmental impact compared to traditional forging and machining-based method. Furthermore, a futuristic scenario that involves in-house tank production using the novel approach with minimal transportation of inventories was also simulated. Based on the LCA results, it was seen that the newly developed approach for manufacturing propellant tanks was more environmentally friendly than the traditional approach and its environmental footprint could be further reduced by implementing the futuristic scenario with minimal transportation. This novel approach is also expected to reduce the lead time and production cost of manufacturing a propellant tank. Hence, future efforts in cost assessment and further optimization of raw material and energy usage are recommended.
Entropy and Thermodynamic Temperature in Nonequilibrium Classical Thermodynamics as Immediate Consequences of the Hahn–Banach Theorem: II Properties
Authors: Feinberg Martin , Lavine Richard B. 
Published: May 2024

AbstractIn a companion article it was shown in a certain precise sense that, for any thermodynamical theory that respects the Kelvin–Planck second law, the Hahn–Banach theorem immediately ensures the existence of a pair of continuous functions of the local material state—a specific entropy (entropy per mass) and a thermodynamic temperature—that together satisfy the Clausius–Duhem inequality for every process. There was no requirement that the local states considered be states of equilibrium. This article addresses questions about properties of the entropy and thermodynamic temperature functions so obtained: To what extent do such temperature functions provide a faithful reflection of “hotness”? In precisely which Kelvin–Planck theories is such a temperature function essentially unique, and, among those theories, for which is the entropy function also essentially unique? What is a thermometer for a Kelvin–Planck theory, and, for the theory, what properties does the existence of a thermometer confer? In all of these questions, the Hahn–Banach Theorem again plays a crucial role.
Dutch translation and cultural adaptation of new LYMPH-Q- scales measuring impact on work and lymphedema worry
Authors: Mos Julia S. , Beelen Louise Marie , van Dishoeck Anne-Margreet , Cornacchi Sylvie D. , Kaur Manraj N. , Breitkopf Trisia , Pusic Andrea L. , Klassen Anne F. , Vasilic Dalibor 
Published: May 2024

Abstract

Background
Breast cancer-related lymphedema (BCRL) is a significant complication of breast cancer treatment that can impact patients’ quality of life. This study focuses on the translation and cultural adaptation of two new LYMPH-Q scales ‘Impact on Work’ and ‘Lymphedema worry’ into Dutch to assess the work-related challenges and worries experienced by patients with BCRL in the Netherlands.

Methods
The translation process followed established guidelines from the International Society for Pharmacoeconomics and Outcomes Research (ISPOR) and the World Health Organization (WHO). Forward and back translations, expert panel reviews, cognitive debriefing interviews with patients with BCRL, and proofreading were conducted to refine the Dutch translation of the scales. The translation aimed to ensure conceptual equivalence and cultural relevance.

Results
The translation process resulted in the Dutch versions of the LYMPH-Q ‘Impact on Work’ and ‘Lymphedema worry’ scales. The forward translation revealed discrepancies in meaning, word order and synonyms. The back translation and review resulted in changes in item formulation. The expert panel meeting and cognitive debriefing interviews provided valuable input for further refinement.

Conclusion
The translated LYMPH-Q ‘Impact on Work’ and ‘Lymphedema worry’ scales provide healthcare professionals with an instrument to assess and monitor the impact of BCRL on work-related challenges and on worries. This comprehensive translation process, involving patients with BCRL and experts, ensured the linguistic accuracy, cultural relevance, and clarity of the Dutch versions. The translated scales will contribute to a better understanding of the multifaceted impact of BCRL and facilitate the development of tailored interventions to improve patients’ well-being and functional outcomes.

Level of Evidence:
Not ratable
Radiolabelling and preclinical characterisation of [89Zr]Zr-Df-ATG-101 bispecific to PD-L1/4–1BB
Authors: Cao Zhipeng , Wichmann Christian Werner , Burvenich Ingrid Julienne Georgette , Osellame Laura Danielle , Guo Nancy , Rigopoulos Angela , O’Keefe Graeme Joseph , Scott Fiona Elizabeth , Lorensuhewa Nirmal , Lynch Kevin Patrick , Scott Andrew Mark 
Published: May 2024

Abstract
Purpose
ATG-101, a bispecific antibody that simultaneously targets the immune checkpoint PD-L1 and the costimulatory receptor 4-1BB, activates exhausted T cells upon PD-L1 crosslinking. Previous studies demonstrated promising anti-tumour efficacy of ATG-101 in preclinical models. Here, we labelled ATG-101 with 89Zr to confirm its tumour targeting effect and tissue biodistribution in a preclinical model. We also evaluated the use of immuno-PET to study tumour uptake of ATG-101 in vivo.

Methods
ATG-101, anti-PD-L1, and an isotype control were conjugated with p-SCN-Deferoxamine (Df). The Df-conjugated antibodies were radiolabelled with 89Zr, and their radiochemical purity, immunoreactivity, and serum stability were assessed. We conducted PET/MRI and biodistribution studies on [89Zr]Zr-Df-ATG-101 in BALB/c nude mice bearing PD-L1-expressing MDA-MB-231 breast cancer xenografts for up to 10 days after intravenous administration of [89Zr]Zr-labelled antibodies. The specificity of [89Zr]Zr-Df-ATG-101 was evaluated through a competition study with unlabelled ATG-101 and anti-PD-L1 antibodies.

Results
The Df-conjugation and [89Zr]Zr -radiolabelling did not affect the target binding of ATG-101. Biodistribution and imaging studies demonstrated biological similarity of [89Zr]Zr-Df-ATG-101 and [89Zr]Zr-Df-anti-PD-L1. Tumour uptake of [89Zr]Zr-Df-ATG-101 was clearly visualised using small-animal PET imaging up to 7 days post-injection. Competition studies confirmed the specificity of PD-L1 targeting in vivo.

Conclusion
[89Zr]Zr-Df-ATG-101 in vivo distribution is dependent on PD-L1 expression in the MDA-MB-231 xenograft model. Immuno-PET with [89Zr]Zr-Df-ATG-101 provides real-time information about ATG-101 distribution and tumour uptake in vivo. Our data support the use of [89Zr]Zr-Df-ATG-101 to assess tumour and tissue uptake of ATG-101.