bluuebunny/crossref_metadata_2025_split huggingface dataset:
TAO: Re-Thinking DL-based Microarchitecture Simulation
Authors: Pandey Santosh , Yazdanbakhsh Amir , Liu Hang 
Published: May 2024

Microarchitecture simulators are indispensable tools for microarchitecture designers to validate, estimate, optimize, and manufacture new hardware that meets specific design requirements. While the quest for a fast, accurate and detailed microarchitecture simulation has been ongoing for decades, existing simulators excel and fall short at different aspects: (i) Although execution-driven simulation is accurate and detailed, it is extremely slow and requires expert-level experience to design. (ii) Trace-driven simulation reuses the execution traces in pursuit of fast simulation but faces accuracy concerns and fails to achieve significant speedup. (iii) Emerging deep learning (DL)-based simulations are remarkably fast and have acceptable accuracy, but fail to provide adequate low-level microarchitectural performance metrics such as branch mispredictions or cache misses, which is crucial for microarchitectural bottleneck analysis. Additionally, they introduce substantial overheads from trace regeneration and model re-training when simulating a new microarchitecture.
Re-thinking the advantages and limitations of the aforementioned three mainstream simulation paradigms, this paper introduces TAO that redesigns the DL-based simulation with three primary contributions: First, we propose a new training dataset design such that the subsequent simulation (i.e., inference) only needs functional trace as inputs, which can be rapidly generated and reused across microarchitectures. Second, to increase the detail of the simulation, we redesign the input features and the DL model using self-attention to support predicting various performance metrics of interest. Third, we propose techniques to train a microarchitecture agnostic embedding layer that enables fast transfer learning between different microarchitectural configurations and effectively reduces the re-training overhead of conventional DL-based simulators. TAO can predict various performance metrics of interest, significantly reduce the simulation time, and maintain similar simulation accuracy as state-of-the-art DL-based endeavors. Our extensive evaluation shows TAO can reduce the overall training and simulation time by 18.06x over the state-of-the-art DL-based endeavors.
FDA Approval Summary: Fruquintinib for the Treatment of Refractory Metastatic Colorectal Cancer
Authors: Fusco Michael J. , Casak Sandra J. , Mushti Sirisha L. , Cheng Joyce , Christmas Brian J. , Thompson Matthew D. , Fu Wentao , Wang Hezhen , Yoon Miyoung , Yang Yuching , Moore Jason N. , Bi Youwei , Nan Yang , Long Craig E. , Auth Doris , Rahman Nam A. , Tang Shenghui , Pazdur Richard , Fashoyin-Aje Lola A. , Kluetz Paul G. , Lemery Steven J. 
Published: May 2024

Abstract
On November 8, 2023, the FDA approved fruquintinib, an inhibitor of vascular endothelial growth factor receptor (VEGFR)-1, -2, and -3, for the treatment of patients with metastatic colorectal cancer (mCRC) who have been previously treated with fluoropyrimidine-, oxaliplatin-, and irinotecan-based chemotherapy, an anti-VEGF therapy, and if RAS wild-type and medically appropriate, an anti-EGFR therapy. Approval was based on Study FRESCO-2, a globally conducted, double-blind, placebo-controlled randomized trial. The primary endpoint was overall survival (OS). The key secondary endpoint was progression-free survival. A total of 691 patients were randomly assigned (461 and 230 into the fruquintinib and placebo arms, respectively). Fruquintinib provided a statistically significant improvement in OS with a hazard ratio (HR) of 0.66 [95% confidence interval (CI), 0.55, 0.80; P &lt; 0.001]. The median OS was 7.4 months (95% CI, 6.7, 8.2) in the fruquintinib arm and 4.8 months (95% CI, 4.0, 5.8) for the placebo arm. Adverse events observed were generally consistent with the known safety profile associated with the inhibition of VEGFR. The results of FRESCO-2 were supported by the FRESCO study, a double-blind, single-country, placebo-controlled, randomized trial in patients with refractory mCRC who have been previously treated with fluoropyrimidine-, oxaliplatin-, and irinotecan-based chemotherapy. In FRESCO, the OS HR was 0.65 (95% CI, 0.51, 0.83; P &lt; 0.001). FDA concluded that the totality of the evidence from FRESCO-2 and FRESCO supported an indication for patients with mCRC with prior treatment with fluoropyrimidine, oxaliplatin-, and irinotecan-based chemotherapy, an anti-VEGF biological therapy, and if RAS wild-type and medically appropriate, an anti-EGFR therapy.
Venetoclax Induces BCL-2–Dependent Treg to TH17 Plasticity to Enhance the Antitumor Efficacy of Anti–PD-1 Checkpoint Blockade
Authors: Liao Rosy , Hsu Jocelyn Y. , Aboelella Nada S. , McKeever Joshua A. , Thomas-Toth Anika T. , Koh Andrew S. , LaBelle James L. 
Published: May 2024

Abstract
The specific BCL-2 small molecule inhibitor venetoclax induces apoptosis in a wide range of malignancies, which has led to rapid clinical expansion in its use alone and in combination with chemotherapy and immune-based therapies against a myriad of cancer types. While lymphocytes, and T cells in particular, rely heavily on BCL-2 for survival and function, the effects of small molecule blockade of the BCL-2 family on surviving immune cells is not fully understood. We aimed to better understand the effect of systemic treatment with venetoclax on regulatory T cells (Treg), which are relatively resistant to cell death induced by specific drugging of BCL-2 compared to other T cells. We found that BCL-2 blockade altered Treg transcriptional profiles and mediated Treg plasticity toward a TH17-like Treg phenotype, resulting in increased IL17A production in lymphoid organs and within the tumor microenvironment. Aligned with previously described augmented antitumor effects observed when combining venetoclax with anti–PD-1 checkpoint inhibition, we also demonstrated that Treg-specific genetic BCL-2 knockout combined with anti–PD-1 induced tumor regression and conferred overlapping genetic changes with venetoclax-treated Tregs. As long-term combination therapies using venetoclax gain more traction in the clinic, an improved understanding of the immune-modulatory effects caused by venetoclax may allow expansion of its use against malignancies and immune-related diseases.
Introduction
Authors: Mehl Margaret 
Published: May 2024

The Introduction outlines the case for treating music, in the broad sense of music-related activities, as part of the general history of human activity, with reference to relevant (albeit scarce) scholarship. The author argues that examining music provides a valuable path to understanding global processes such as globalization in the sense of global integration, and the formation of national identity. The main argument is stated, namely that music was central to the making of modern Japan, and a brief chapter-by-chapter outline relates their respective topics to the overall theme.
The main section of the book is divided into three interconnected parts, relating to the global, the national, and the local level. Globalization and nation-building, two major trends in the nineteenth and twentieth centuries, can only be fully understood if developments in the different and diverse localities within the nation’s borders are taken into account: a nation-state has to unite the people within its borders. The chapters in Part Three are central to the book (which is reflected in their length and level of detail), because it is at the local level that we see most clearly the vital role played by music in drawing together the Japanese people in order to actively participate in the nation as well as experiencing themselves as part of a world of nation. It is also at the local level that the importance of personal initiative by individuals is most evident.
6. Civilizing Citizens
Authors: Mehl Margaret 
Published: May 2024

Chapter 6, ‘Civilizing Citizens: Music Reform’ discusses Isawa’s goal of reforming Japanese music with the help of Western music. In this he was joined by other members of the Meiji elite, and the topic is discussed in. Strongly influenced by their education in the Chinese classics (kangaku), reformers argued that reforming music was an essential means to reform the manners and customs of the people. Japanese music was perceived to be unsuited to the purpose, while Western music was perceived to have desirable characteristics that Japanese music lacked. The need for music reform became a major argument in defence of the Tokyo Academy of Music when it was threatened by budget cuts in 1890. Ultimately, official efforts at blending Western and Japanese music were short-lived.
Compared to Isawa, the role of non-state actors in the dissemination of Western music has received little attention.
7. Shikama Totsuji
Authors: Mehl Margaret 
Published: May 2024

Chapter 7, ‘Shikama Totsuji: Music Reform and a Nationwide Network’ introduces one of them, whose importance is equal to Isawa’s. In 1890, just before the debate about the role of the Tokyo Academy of Music took off, Shikama Totsuji founded Japan’s first magazine devoted to music: Ongaku zasshi, with the additional English title, The Musical Magazine. Shikama had completed a short training course for music teachers at the Academy, and his stated purpose was to promote music reform. In addition, Shikama Totsuji engaged in several other music-related activities to further his agenda. They underline the scope of his ambitions and illustrate the way individual actors, often (like Shikama himself) with minimal training in Western music, contributed to transforming musical culture.
Shikama and other individual actors continued to pursue music reform after official efforts had ceased.
Evaluation of Biomechanical and Mental Workload During Human–Robot Collaborative Pollination Task
Authors: Yerebakan Mustafa Ozkan , Gu Yu , Gross Jason , Hu Boyi 
Published: May 2024

Objective The purpose of this study is to identify the potential biomechanical and cognitive workload effects induced by human robot collaborative pollination task, how additional cues and reliability of the robot influence these effects and whether interacting with the robot influences the participant’s anxiety and attitude towards robots. Background Human–Robot Collaboration (HRC) could be used to alleviate pollinator shortages and robot performance issues. However, the effects of HRC for this setting have not been investigated. Methods Sixteen participants were recruited. Four HRC modes, no cue, with cue, unreliable, and manual control were included. Three categories of dependent variables were measured: (1) spine kinematics (L5/S1, L1/T12, and T1/C7), (2) pupillary activation data, and (3) subjective measures such as perceived workload, robot-related anxiety, and negative attitudes towards robotics. Results HRC reduced anxiety towards the cobot, decreased joint angles and angular velocity for the L5/S1 and L1/T12 joints, and reduced pupil dilation, with the “with cue” mode producing the lowest values. However, unreliability was detrimental to these gains. In addition, HRC resulted in a higher flexion angle for the neck (i.e., T1/C7). Conclusion HRC reduced the physical and mental workload during the simulated pollination task. Benefits of the additional cue were minimal compared to no cues. The increased joint angle in the neck and unreliability affecting lower and mid back joint angles and workload requires further investigation. Application These findings could be used to inform design decisions for HRC frameworks for agricultural applications that are cognizant of the different effects induced by HRC.
Exploring the FAO Minimum Dietary Diversity Indicator as a Suitable Proxy of Micronutrient Adequacy in Men and Women Across Reproductive and Non-reproductive Ages in 8 Latin American Countries
Authors: Gómez Georgina , Monge-Rojas Rafael , Vargas-Quesada Rulamán , Previdelli Agatha Nogueira , Quesada Dayana , Kovalskys Irina , Herrera-Cuenca Marianella , Cortes Lilia Yadira , García Martha Cecilia Yépez , Liria-Domínguez Reyna , Rigotti Attilio , Fisberg Regina Mara , Ferrari Gerson , Fisberg Mauro , Brenes Juan C 
Published: May 2024

Background: Women’s Dietary Diversity Score (WDDS) is an indicator of dietary diversity, a key component of diet quality in women of reproductive age (WRA). Limited information is available regarding its applicability in other population groups. Objective: To examine the ability of the Minimum Dietary Diversity for Women (MDD-W) of 5-food groups cutoff to predict micronutrient adequacy in men and women 15 to 65 years old from 8 Latin American countries. Methods: We used a 24-hour recall from 9216 participants in the Latin American Study on Nutrition and Health (ELANS) to determine Dietary Diversity Score (DDS) based on the consumption of 10 food groups. The Mean Probability of Adequacy (MPA) was associated with DDS for the overall sample, for men, WRA, and women of nonreproductive age (WNRA). Sensitivity and specificity analyses were performed to determine if the 5-food groups cutoff point for MDD can be used to correctly identify men, WRA, and WNRA with adequate micronutrient adequacy (MPA ≥ 0.70). Results: We found a mean DDS of 4.78 ± 1.33 and an MPA of 0.64 ± 0.16, with 59% of participants showing a diverse diet (DDS ≥ 5). The 5-food groups-cutoff point showed a better balance between sensitivity and specificity predicting an MPA ≥0.70 in men, WRA, and WNRA. MPA was significantly associated with DDS in WRA and for men and WNRA, as well. Conclusion: The 5-food group MDD, originally intended to be used in WRA, performed equally well in predicting MPA ≥0.70 in men, WRA, and WNRA, and can be used as a proxy of micronutrient adequacy in Latin American population.
Clinical Staging for Personality Disorders in Older Adults
Authors: Conjaerts Jeroen A. P. , Videler Arjan C. , Schepman Roel , Elfeddali Iman , Rosowsky Erlene , van Alphen Sebastiaan P. J. 
Published: May 2024

Objective This scientific research aimed to investigate the feasibility of implementing a clinical staging (CS) model for personality disorders (PDs) in older adults. The CS model could provide valuable insights into the life course of personality pathology, prognosis, and treatment decisions for PDs in older adults. Methods/Design The study employed an international Delphi methodology with three rounds and involved 21 experts. Results Consensus was achieved on 12 out of 17 statements, confirming the viability of a CS model for PDs in older adults. The proposed model incorporates the Alternative Model for PDs, criterion A, and integrates life course information, distinguishing between chronic PD, re-emergent PD, late-onset PD, and past PD. Conclusion The findings suggest that international experts support the implementation of a CS model for PDs in older adults, considering both the severity of personality functioning and the retrospective life course of PD expression.
Evaluation of Methods to Obtain Peripheral Blood Mononuclear Cells From Deceased Donors for Tolerance-Induction Protocols
Authors: Yao Ming , Henriksson Jarmo , Fahlander Henrik , Guisti Coitinho Pablo , Lundgren Torbjörn , Ågren Nils , Ericzon Bo-Göran , Kumagai-Braesch Makiko 
Published: May 2024

Regulatory cell therapies have shown promise in tolerance-induction protocols in living donor organ transplantation. These protocols should be pursued in deceased donor transplantation. Donor peripheral mononuclear cells (PBMCs) are an optimal source of donor antigens for the induction of donor-specific regulatory cells. During the development of a regulatory cell tolerance-induction protocol with organs from deceased donors, we compared 3 methods of obtaining PBMCs from deceased donors focusing on cell yield, viability, and contamination of unwanted cell types.  PBMC procurement methods:  1. During organ procurement at the time of cold perfusion, blood was collected from the vena cava and placed into a 10-liter blood collection bag, and thereafter transported to Karolinska University Hospital, where leukapheresis was performed (BCL).  2. Blood was collected via the vena cava into blood donation bags before cold perfusion. The bags underwent buffy coat separation and thereafter automated leukocyte isolation system (BCS).  3. To collect PBMCs, leukapheresis was performed via a central dialysis catheter on deceased donors in the intensive care unit (ICU) prior to the organ procurement procedure (LEU). All 3 methods to obtain PBMC from deceased donors were safe and did not affect the procurement of organs. BCL contained around 50% of NK cells in lymphocytes population. LEU had a highest yield of donor PBMC among 3 groups. LEU had the lower amount of granulocyte contamination, compared to BCS and BCL. Based on these results, we choose LEU as the preferred method to obtain donor PBMC in the development of our tolerance-induction protocol.
Prediction of vitreomacular traction syndrome outcomes with deep learning: A pilot study
Authors: Usmani Eiman , Bacchi Stephen , Zhang Hao , Guymer Chelsea , Kraczkowska Amber , Qinfeng Shi Javen , Gilhotra Jagjit , Chan Weng Onn 
Published: May 2024

Purpose To investigate the potential of an Optical Coherence Tomography (OCT) based Deep-Learning (DL) model in the prediction of Vitreomacular Traction (VMT) syndrome outcomes. Design A single-centre retrospective review. Methods Records of consecutive adult patients attending the Royal Adelaide Hospital vitreoretinal clinic with evidence of spontaneous VMT were reviewed from January 2019 until May 2022. All patients with evidence of causes of cystoid macular oedema or secondary causes of VMT were excluded. OCT scans and outcome data obtained from patient records was used to train, test and then validate the models. Results For the deep learning model, ninety-five patient files were identified from the OCT (SPECTRALIS system; Heidelberg Engineering, Heidelberg, Germany) records. 25% of the patients spontaneously improved, 48% remained stable and 27% had progression of their disease, approximately. The final longitudinal model was able to predict ‘improved’ or ‘stable’ disease with a positive predictive value of 0.72 and 0.79, respectively. The accuracy of the model was greater than 50%. Conclusions Deep-learning models may be utilised in real-world settings to predict outcomes of VMT. This approach requires further investigation as it may improve patient outcomes by aiding ophthalmologists in cross-checking management decisions and reduce the need for unnecessary interventions or delays.
Impact of adverse childhood experiences and family resilience on sleep duration in autistic children
Authors: Sadikova Eleonora , Soland Jim , Menezes Michelle , Mazurek Micah 
Published: May 2024

Autistic children are at higher risk of experiencing adverse childhood experiences, which lead to negative health outcomes such as sleep difficulties. In the general population, family resilience can help reduce the negative impact of adverse childhood experiences on child functioning. The aim of this study was to examine the impact of adverse childhood experiences on sleep duration, and whether family resilience moderates this impact in autistic children. With data from 2882 caregivers of children with autism from the National Survey of Children’s Health, we examined the role of family resilience on the relationship between adverse childhood experiences and sleep duration. As shown in previous findings, there was a main effect of adverse childhood experiences on sleep duration. There was no significant main effect of family resilience on sleep duration. Results also show that family resilience moderates the relationship between adverse childhood experiences and sleep duration, possibly serving as a protective factor. Lay abstract Autistic children are more likely to have sleep difficulties and to experience adverse childhood experiences. Adverse childhood experiences can include parental divorce, bullying, or witnessing violence. We also know that children in families who are resilient (e.g. families who are connected, work together, and help each other) are less impacted by adverse childhood experiences. Our study examined whether there was a relationship between adverse childhood experiences and sleep duration in autistic children. We also wanted to find out whether family resilience protects from the negative impact of adverse childhood experiences on sleep duration. We used data from 3247 parent surveys about their children that we got from the National Survey of Children’s Health. We found that children with adverse childhood experiences are more likely to get less sleep. We also found that children with resilient families were more likely to get more sleep. Our results show that family resilience helps weaken the relationship between adverse childhood experiences and sleep, so it is important to help families build resilience.
Multicentric Use of Commercially Available Infrarenal Endografts During Fenestrated Endovascular Aortic Repair: A Feasibility Study
Authors: Karelis Angelos , Jonsson Magnus , Budtz-Lilly Jacob , Jirström Wendela , Sonesson Björn , Dias Nuno V. 
Published: May 2024

Purpose: This study aimed to assess the feasibility and short-term outcomes of different manufactured proximal and distal stent graft components during fenestrated endovascular aortic repair (FEVAR). Materials and methods: A multicenter retrospective review was conducted at 3 aortic centers, involving all consecutive patients who underwent FEVAR utilizing a customized Dacron-based tubular proximal and a distal bifurcated polytetrafluoreten (PTFE)-based commercially available stent grafts. Primary outcomes were 30 day mortality, major adverse events, and technical and clinical success. Secondary outcomes assessed stent graft migration, occurrence of types I/III endoleak, and reintervention. Results: A total of 23 FEVAR cases across all centers were included in this study. Technical success was achieved in all cases, with a median procedure time of 183 (153–244) minutes. There were no major adverse events, except for 1 transient acute renal failure. The median follow-up period was 23 (17–28) months. All target vessels retained patent with the exception of 1 right renal fenestration that showed signs of kinking at the first follow-up, and despite secondary intervention with relining and distal extension, there was an occlusion afterward and 1 hepatic artery with a separate fenestration. This and 1 successful relining of a superior mesenteric artery kink were the only reinterventions in this cohort. One case of persistent type 1b endoleak was reported in a patient with chronic type B aortic dissection, which resolved with distal extension on the external iliac artery 5 months after the index procedure. No deaths occurred throughout the follow-up with, and there were no signs of stent graft migration or type 3 endoleak. Conclusion: The use of commercially available PTFE-based bifurcated stent grafts to extend distally the tubular graft appears to be a feasible approach during FEVAR, with promising short-term outcomes. Further studies are necessary to define the applicability of this solution and evaluate long-term outcomes. Clinical Impact This multicentric study on fenestrated endovascular aortic repair (FEVAR) demonstrates the feasibility and good short-term outcomes of utilizing a PTFE-based commercially available stent graft to extend the proximal tubular custom-made fenestrated stent graft. The high technical success rate, absence of major adverse events, and low occurrence of complications such as stent graft migration and endoleaks highlight the potential clinical benefits of this approach with an off-the-shelf distal extension whose delivery system does not cross the fenestrations intraoperatively.