bluuebunny/crossref_metadata_2025_split huggingface dataset:
Financial contagion: evolutionary optimization of a multinational agent‐based model
Authors: Caporale Guglielmo Maria , Serguieva Antoaneta , Wu Hao 
Published: July 2009

AbstractOver the past two decades, financial market crises with similar features have occurred in different regions of the world. Unstable cross‐market linkages during a crisis are referred to as financial contagion. We simulate crisis transmission in the context of a model of market participants adopting various strategies; this allows testing for financial contagion under alternative scenarios. Using a minority game approach, we develop an agent‐based multinational model and investigate the reasons for contagion. Although the phenomenon has been extensively investigated in the financial literature, it has not been studied through computational intelligence techniques. Our simulations shed light on parameter values and characteristics which can be exploited to detect contagion at an earlier stage, hence recognizing financial crises with the potential to destabilize cross‐market linkages. In the real world, such information would be extremely valuable in developing appropriate risk management strategies. Copyright © 2009 John Wiley & Sons, Ltd.
Return performance volatility and adaptation in an automated technical analysis approach to portfolio management
Authors: Ghandar Adam , Michalewicz Zbigniew , Zurbruegg Ralf 
Published: July 2009

AbstractThis paper discusses the design of a quantitative computational intelligence portfolio management system and evaluates the advantages of some adaptive mechanisms to enable the system to adjust its management approach as market conditions change. A detailed analysis of the performance of the system outside is also provided. It is found that an adaptive methodology where trading rules are able to adjust to market conditions performs better, having greater excess returns and lower volatility than a fixed rule approach. We consider several performance metrics, including portfolio alpha and information content. Copyright © 2009 John Wiley & Sons, Ltd.
Dynamic interaction networks in modelling and predicting the behaviour of multiple interactive stock markets
Authors: Widiputra Harya , Pears Russel , Serguieva Antoaneta , Kasabov Nikola 
Published: July 2009

AbstractThe behaviour of multiple stock markets can be described within the framework of complex dynamic systems. A representative technique of the framework is the dynamic interaction network (DIN), recently developed in the bioinformatics domain. DINs are capable of modelling dynamic interactions between genes and predicting their future expressions. In this paper, we adopt a DIN approach to extract and model interactions between stock markets. The network is further able to learn online and updates incrementally with the unfolding of the stock market time‐series. The approach is applied to a case study involving 10 market indexes in the Asia Pacific region. The results show that the DIN model reveals important and complex dynamic relationships between stock markets, demonstrating the ability of complex dynamic systems approaches to go beyond the scope of traditional statistical methods. Copyright © 2009 John Wiley & Sons, Ltd.
Ectopic osteogenic ability of calcium phosphate scaffolds cultured with osteoblasts
Authors: Nan Kaihui , Sun Shumao , Li Yuli , Chen Hao , Wu Tao , Lu Fan 
Published: July 2009

AbstractBone substitute materials can induce bone formation when combined with mesenchymal stem cells (MSC). The aim of the current study was to examine in vivo ectopic bone formation with MSC on tricalcium phosphate (TCP) ceramics. Osteoblasts isolated from bone marrow stromal cells (BMSCs) of New Zealand rabbits were cultured with TCP ceramics for 10 days, followed by implantation of the cultured TCP ceramics into the rabbit dorsum muscle. The cultured TCP and in vivo new bone formation with TCP biodegradation were evaluated histologically. Scanning electron microscopy showed that the surface of the cultured TCP ceramics was filled by osteoblasts with a cell‐free zone in the central area. New bone was formed on the cultured TCP ceramics with signs of gradual degradation of TCP ceramics at 8 weeks of implantation, indicating that TCP could be a potential scaffold for seeding cells used for development of bioengineering tissues. © 2009 Wiley Periodicals, Inc. J Biomed Mater Res 2010
Porcine gelatin microsphere/calcium phosphate cement composites: An in vitro degradation study
Authors: Habraken Wouter J. E. M. , Wolke Joop G. C. , Mikos Antonios G. , Jansen John A. 
Published: July 2009

AbstractScaffolds for bone tissue engineering preferably should be mechanically stable, osteoconductive, biodegradable and porous. To comply with these characteristics, calcium phosphate cements (CPCs) with porcine (type A) gelatin microspheres were formulated. In this experiment, in vitro degradation of 10 wt % gelatin type A microsphere CPCs (GELA CPCs) was followed for 12 weeks in proteolytic medium. Results showed a gradual decrease in mass, compression strength and E‐modulus. Morphology investigation showed that degradation of the spheres started at the surface of the composite and gradually proceeded to the inner part. Overall, porcine gelatin microspheres can be used to generate in situ macroporosity into an injectable CPC. © 2009 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 2009
Experimental immediate loading of dental implants in conjunction with grafting procedures
Authors: Neugebauer Joerg , Iezzi Giovanna , Perrotti Vittoria , Fischer Juergen H. , Khoury Fouad , Piattelli Adriano , Zoeller Joachim E. 
Published: July 2009

AbstractThe aim of this study was to evaluate immediate loading (IL) of dental implants in conjunction with grafting procedures. A total of 107 IL implants were inserted in six mini pigs. Before implant placement, crestal or apical defects were created, which were treated with bone chips, phycogene hydroxyapatite (HA), bovine HA, or bovine HA enhanced with a synthetic peptide. Crestal grafts were stabilized with titanium membranes. All bridges were in function and showed signs of chewing wear after 4‐month loading. Three out of 107 implants showed no osseointegration (2.7%). Most of the crestal defects showed incomplete regeneration, due to an infection of the membranes (74.3%) The difference in height between surgical and remaining defect was calculated as defect development, which was 2.3 ± 2.08 mm for bone chips with an area of regenerated bone of 22.8 ± 3.34% and 0.7 ± 2.22 mm for phycogene HA with 11.3 ± 4.36% regenerated bone. Bovine HA showed an increase of defects 1.3 ± 2.47 mm with only 7.9 ± 1.7% bone regeneration. Bovine HA enhanced with a peptide showed a defect development of 1.1 ± 1.42 mm with an area of regenerated bone of 18.2 ± 2.38%. In conclusion, local grafting procedures did not disturb the course of osseointegration for immediate loaded implants if primary stability was reached. The regeneration of apical defects was uneventful even with immediate loading. Crestal defects required membrane fixation with a careful flap elevation to avoid membrane exposure and loss of the graft. © 2009 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2009
ATR‐FTIR as a thickness measurement technique for hydrated polymer‐on‐polymer coatings
Authors: Kane Sheryl R. , Ashby Paul D. , Pruitt Lisa A. 
Published: July 2009

AbstractHydrated polymer coatings on polymer substrates are common for many biomedical applications, such as tissue engineering constructs, contact lenses, and catheters. The thickness of the coatings can affect the mechanical behavior of the systems and the cellular response, but measuring the coating thickness can be quite challenging using conventional methods. We propose a new method, that is, attenuated total reflection Fourier transform infrared spectroscopy (ATR‐FTIR) to determine the relative thickness, combined with atomic force microscopy to calibrate the ATR‐FTIR measurements. This technique was successfully employed to determine the hydrated thickness of a series of crosslinked tetraglyme coatings on ultrahigh molecular weight polyethylene substrates intended to reduce wear of acetabular cups in total hip replacements. The hydrated coatings ranged from 30 to 200 nm thick and were accurately measured despite the relatively high root‐mean‐square (RMS) roughness of the substrates, 20–35 nm (peak‐to‐peak roughness 55–100 nm). The calibrated ATR‐FTIR technique is a promising new method for measuring the thickness of many other polymer‐on‐polymer and hydrated coatings. © 2009 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2009
Evaluation of encapsulated Newcastle disease virus liposomes using various phospholipids administered to improve chicken humoral immunity
Authors: Tseng Li‐Ping , Chiou Chwei‐Jang , Deng Ming‐Chung , Lin Mei‐Hsiu , Pan Ryh‐Nan , Huang Yi‐You , Liu Der‐Zen 
Published: July 2009

AbstractWe propose the adjuvant effects of phospholipid liposome compositions using intranasal inoculation of a liposomal‐Newcastle disease virus (NDV) vaccine in chickens. The immunogenicity of three liposome formulations was determined in chickens using the hemagglutination‐inhibition (HI) test, nasal secretory immunoglobulin A and serum immunoglobulin A (IgG) antibody titers using the enzyme‐linked immunosorbent assay. The immune response against NDV antigens was determined after immunization with neutral charged liposomes composed of egg phosphatidylcholine (EPC) (60 μmol), cholesterol (Chol) (15 μmol), and EPC‐liposomes (EPC‐Lip), which elicited strong systemic (serum) and local (nasal) humoral responses. However, the intranasal administration with cationic charged liposomes composed of EPC (30 μmol), stearylamine (SA) (15 μmol), Chol (15 μmol), and SA‐liposomes (SA‐Lip) induced poor humoral immune responses. Only the vaccine formulated with anionic charged liposomes composed of EPC (30 μmol), dipalmitoylphosphatidylserine (15 μmol), Chol (15 μmol), and phosphatidylserine‐liposomes (PS‐Lip) elicited the highest titers of HI antibodies. These are the first results to suggest that antigen delivery using EPC‐Lip is very useful in enhancing antibody production at the mucosal site and in serum. © 2009 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2009
A comparison of experimental aneurysm occlusion determination by angiography, scanning electron microscopy, MICROFIL® perfusion, and histology
Authors: Cruise Gregory M. , Rivera Elias A. , Jones Russell M. , Vestal Maria , Virmani Renu , Ding Yong‐Hong , Kallmes David F. 
Published: July 2009

AbstractIn clinical practice, occlusion of embolized, intracerebral aneurysms is evaluated using angiography. Standard, two‐dimensional digital subtract angiography (DSA) is unable to quantify irregular aneurysm remnants, and even three‐dimensional rotational angiography cannot quantify the degree of occlusion. To better understand occlusion at the aneurysm neck, we compared angiographic results with MICROFIL® perfusion, histology, and scanning electron microscopy (SEM) results in 20 elastase‐induced saccular aneurysms in rabbits. Aneurysms were embolized with HydroCoil devices (n = 12) or platinum coils (n = 8). Aneurysm follow‐up occurred at 2 (n = 10) and 6 (n = 10) weeks. Aneurysm occlusion was evaluated using DSA, MICROFIL perfusion, histological ground sections, and SEM. Groups were compared statistically using ANOVA and χ2 tests. The MICROFIL perfusion results were not concordant with the angiographic results for the HydroCoil and platinum coil groups. Both increased and decreased occlusion was observed on the MICROFIL‐perfused aneurysms when compared with angiography. The histologic occlusion results of the HydroCoil group were concordant with the angiographic results; however, unoccluded areas not visible on angiography were routinely observed on the ground sections in the platinum coil group. SEM imaging of the aneurysm neck consistently showed decreased occlusion than angiographic results for both the HydroCoil and platinum coil groups. Although histology and MICROFIL‐perfusion analyses provided additional details of aneurysm occlusion when compared with angiography, complete visualization of the entire neck of the aneurysm and accurate assessment of aneurysm occlusion was possible only with SEM. © 2009 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2009
Nonlinear visco‐elastic finite element analysis of different porcelain veneers configuration
Authors: Sorrentino Roberto , Apicella Davide , Riccio Carlo , Gherlone Enrico , Zarone Fernando , Aversa Raffaella , Garcia‐Godoy Franklin , Ferrari Marco , Apicella Antonio 
Published: July 2009

AbstractThis study is aimed at evaluating the biomechanical behavior of feldspathic versus alumina porcelain veneers. A 3D numerical model of a maxillary central incisor, with the periodontal ligament (PDL) and the alveolar bone was generated. Such model was made up of four main volumes: dentin, enamel, cement layer and veneer. Incisors restored with alumina and feldspathic porcelain veneers were compared with a natural sound tooth (control). Enamel, cementum, cancellous and cortical bone were considered as isotropic elastic materials; on the contrary, the tubular structure of dentin was designed as elastic orthotropic. The nonlinear visco‐elatic behavior of the PDL was considered. The veneer volumes were coupled with alumina and feldspathic porcelain mechanical properties. The adhesive layers were modeled in the FE environment using spring elements. A 50N load applied at 60° angle with tooth longitudinal axis was applied and validated. Compressive stresses were concentrated on the external surface of the buccal side of the veneer close to the incisal margin; such phenomenon was more evident in the presence of alumina. Tensile stresses were negligible when compared to compressive ones. Alumina and feldspathic ceramic were characterized by a different biomechanical behavior in terms of elastic deformations and stress distributions. The ultimate strength of both materials was not overcome in the performed analysis. © 2009 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2009
Mold fabrication and biological assessment of porous DNA–chitosan complexes
Authors: Fukushima Tadao , Ohno Jun , Hayakawa Tohru , Kawaguchi Minoru , Inoue Yusuke , Takeda Shoji , Toyoda Mika , Okahata Yoshio 
Published: July 2009

AbstractA previous study revealed that DNA–chitosan complex prepared from the reaction between native DNA and chitosan in aqueous solution has suitable porosity for cell seeding, is nontoxic, and causes only a mild soft‐tissue response. This simple and easy fabrication method for porous DNA–chitosan complex provides for a wide variety of applications as a scaffold material. The present study evaluated whether rinsing with PBS solution can fabricate DNA–chitosan complex in a mold and the histopathological responses of rat soft tissues to fabricated DNA–chitosan complexes. DNA–chitosan complex paste was prepared by mixing distilled water and freeze‐dried water‐rinsed DNA–chitosan complex powder. A DNA–chitosan complex disk could be fabricated by rinsing with PBS buffer and subsequently freeze‐drying the DNA–chitosan complex paste in the mold. Thus, a wide range of applications of DNA–chitosan complex for tissue engineering can be anticipated using the present easy fabrication method. The porosity of the disk was 85%, and many pores were visible in the DNA–chitosan complex (before fabrication) and in the fabricated DNA–chitosan disk. The values of the complex disks gradually reduced in the tissues although 60% of disks remained in the tissues. In conclusion, an easy fabrication method for making porous DNA–chitosan complex disks was developed. It was found that the fabrication method can delay the biodegradation of the DNA–chitosan complex disk without serious tissue responses in vivo. DNA–chitosan complex is promising as a scaffold material, and a wide range of applications of DNA–chitosan complex for tissue engineering are anticipated. © 2009 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2009
Preparation of a completely autologous trileaflet valve‐shaped construct by in‐body tissue architecture technology
Authors: Nakayama Yasuhide , Yamanami Masashi , Yahata Yuki , Tajikawa Tsutomu , Ohba Kenkichi , Watanabe Taiji , Kanda Keiichi , Yaku Hitoshi 
Published: July 2009

AbstractThe aim of this study was to prepare completely autologous heart‐valve‐shaped constructs without using any artificial scaffold materials by in‐body tissue architecture technology, which is a practical concept of regenerative medicine based on the biological defense mechanism against foreign bodies. Silicone rods were used as molds to achieve the tubular shape of the arteries, which were implanted in the subcutaneous spaces of rabbits. After 2 weeks of primary in‐body tissue incubation, the silicone rods were completely encapsulated within a thin membranous connective tissue mainly consisting of collagen and having a thickness of ∼100 μm. To achieve the trileaflet shape of the valve, the cylindrical tissues obtained were rolled up with polyurethane belts cut in the shape of three semi‐ovals. The assembled tissues were reimplanted for 2 weeks for secondary incubation. The resulting tissues were over‐encapsulated with the newly developed membranous connective tissue having a thickness of ∼200–400 μm. The newly formed membranes were completely fused to the previously developed inner membrane. After the removal of the two artificial materials, tubular constructs with trileaflet‐shaped internal surface were obtained. By controlling the formation of the encapsulating tissue in the two‐step in‐body tissue incubation process, we were able to develop completely autologous trileaflet valve‐shaped constructs. © 2009 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2009
High molecular weight blood group A trisaccharide‐polyacrylamide glycoconjugates as synthetic blood group A antigens for anti‐A antibody removal devices
Authors: Alikhani Azadeh , Korchagina Elena Y. , Chinarev Alexander A. , Bovin Nicolai V. , Federspiel William J. 
Published: July 2009

AbstractSpecific immunoadsorption of blood group antibodies by synthetic antigens immobilized on support matrices in the peri‐transplantation period provides a promising solution to hyperacute rejection risk following ABO‐incompatible transplantation. In this study, we investigated binding interactions between anti‐A antibodies and synthetic blood group A trisaccharide conjugated with polyacrylamide of different molecular weights (30 and 1000 kDa). The glycopolymers were equipped with biotin tags and deposited on streptavidin‐coated sensor chips. The affinity and kinetics of anti‐A antibodies binding to glycoconjugates were studied using surface plasmon resonance (SPR). The high molecular weight conjugate (Atri‐PAA1000‐biotin) enhanced antibody binding capacity by two to three fold compared with the low molecular weight conjugate (Atri‐PAA30‐biotin), whereas varying the carbohydrate content in Atri‐PAA1000‐biotin (20 mol % or 50 mol %) did not affect antibody binding capacity of the glycoconjugate. The obtained results suggest that immunoadsorption devices, especially hollow fiber‐based antibody filters which are limited in available surface area for antigen immobilization, may greatly benefit from the new synthetic high molecular weight polyacrylamide glycoconjugates. © 2009 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2009
PC controls for troubled times
Authors: Reider Rob 
Published: July 2009

AbstractMany businesses of all sizes use personal computers (PCs) to process financial and accounting transactions and prepare financial statements. But many PC software packages are “user friendly” and allow the user to have only limited knowledge of control procedures. In addition, the severe economic downturn is causing downsizing and layoffs—and many disgruntled employees are tempted to steal data and sabotage PCs. Finally, as companies struggle to survive, they implement cost‐cutting measures, lowering the level of computer security even more.So what control measures should you put in place now? What steps are needed? The author supplies some detailed plans you can use immediately to reduce your risks. © 2009 Wiley Periodicals, Inc.
Surviving IT budget cuts with TERPS
Authors: Wright Harry R. , Mooney J. Lowell , Rogers Camille F. 
Published: July 2009

AbstractThe global economic downturn has forced many companies to reevaluate how they do business, in an aggressive effort to cut costs. Budget cuts are reaching 5 to 10 percent or more—and no part of a company is left untouched. But how can companies slash information technology costs and still maintain the same level of production? Here's one interesting strategy: use trained enterprise resource planning students, or TERPS. © 2009 Wiley Periodicals, Inc.
New IT risk framework
Authors: Harrast Steven , Weirich Thomas R. 
Published: July 2009

AbstractThe nonprofit, independent Information Technology Governance Institute (ITGI) recently issued an exposure draft of its new Risk IT Framework. The new framework is reported to be the missing link between enterprise resource management and IT risk management and control. But the greatest challenge posed by the new framework may be to identify all that can go wrong. The authors give us a useful overview of the new guidelines. © 2009 Wiley Periodicals, Inc.
Auditing IT projects
Authors: Bi Lily 
Published: July 2009

AbstractNo matter what industry your company is in, information technology (IT) is critical if you want to maintain a competitive edge, manage risks, and achieve business objectives. One way to ensure IT success is to tap the valuable in‐house expertise of your firm's internal auditors. But what is the best way to audit IT? © 2009 Wiley Periodicals, Inc.
Prostaglandin E2 inhibits the proliferation of human gingival fibroblasts via the EP2 receptor and Epac
Authors: Weinberg Evgeny , Zeldich Ella , Weinreb Max M. , Moses Ofer , Nemcovsky Carlos , Weinreb Miron 
Published: July 2009

AbstractElevated levels of prostaglandins such as PGE2 in inflamed gingiva play a significant role in the tissue destruction caused by periodontitis, partly by targeting local fibroblasts. Only very few studies have shown that PGE2 inhibits the proliferation of a gingival fibroblast (GF) cell line, and we expanded this research by using primary human GFs (hGFs) and looking into the mechanisms of the PGE2 effect. GFs derived from healthy human gingiva were treated with PGE2 and proliferation was assessed by measuring cell number and DNA synthesis and potential signaling pathways were investigated using selective activators or inhibitors. PGE2 inhibited the proliferation of hGFs dose‐dependently. The effect was mimicked by forskolin (adenylate cyclase stimulator) and augmented by IBMX (a cAMP‐breakdown inhibitor), pointing to involvement of cAMP. Indeed, PGE2 and forskolin induced cAMP generation in these cells. Using selective EP receptor agonists we found that the anti‐proliferative effect of PGE2 is mediated via the EP2 receptor (which is coupled to adenylate cyclase activation). We also found that the effect of PGE2 involved activation of Epac (exchange protein directly activated by cAMP), an intracellular cAMP sensor, and not PKA. While serum increased the amount of phospho‐ERK in hGFs by ∼300%, PGE2 decreased it by ∼50%. Finally, the PGE2 effect does not require endogenous production of prostaglandins since it was not abrogated by two COX‐inhibitors. In conclusion, in human gingival fibroblasts PGE2 activates the EP2—cAMP—Epac pathway, reducing ERK phosphorylation and inhibiting proliferation. This effect could hamper periodontal healing and provide further insights into the pathogenesis of inflammatory periodontal disease. J. Cell. Biochem. 108: 207–215, 2009. © 2009 Wiley‐Liss, Inc.