bluuebunny/crossref_metadata_2025_split huggingface dataset:
Uji efek sedatif ekstrak etanol genjer (Limnocharis flava) terhadap mencit (Mus musculus)
Authors: Panduwiguna Ivans , Hardiana Iyan , Priatma Ari Putra , Hardiyati Iin 
Published: May 2024

Tanaman genjer merupakan salah satu jenis tanaman di perairan darat yang telah lama dimanfaatkan oleh masyarakat Indonesia yang digunakan secara empiris sebagai sedatif. Tujuan dari penelitian ini adalah untuk melihat efek sedatif dari ekstrak etanol genjer (Limnocharis flava). Metode uji efek sedasi yang digunakan yaitu metode yang modifikasi berenang paksa (Forced swimming test) dan penggantungan ekor (Tail suspension test) dan menganalisis Immobility time dari mencit tersebut dengan melakukan pengamatan terhadap kelompok kontrol positif dengan dosis diazepam (0,39 mg/g BB) dan perlakuan sesuai dengan dosis yang telah di tetapkan dalam tiga besaran dosis yaitu dosis 1(143 mg/g BB), dosis 2 (214 mg/g BB) dan dosis 3 (283 mg/g BB) tiap ekstrak. Hasil peneltian diketahui bahwa ekstrak etanol batang dan daun genjer (L. Flava) menghasilkan efek sedasi dilihat dari dosis batang 1 sampai 3 bahwa semakin besar dosis semakin terjadi penurunan immobility time pada mencit, sedangkan pada dosis daun 1 sampai 3 terjadi peningkatan gerak pada mencit terlihat dari semakin tinggi dosis maka semakin aktif atau banyaknya mencit bergerak, dimana meningkatkan mobilitas si mencit pada permukaan air dengan hasil Two Way Anova 0,1874. Pada metode tail suspension test kita bisa melihat bahwa mencit cenderung tidak banyak bergerak pada dosis 1 baik batang maupun daun, dan mobilitas mencit meningkat seiring penurunan dosis yang di berikan pada dosis ekstrak batang dan didapati nilai paling baik ialah di dosis 1 batang semakin rendah dosis dapat memiliki efek sedasi yang lebih baik dengan hasil uji wilcoxon 0,0078.
Kata kunci: Gangguan tidur; genjer (Limnocharis flava); sedasi, force swimming test; tail suspension test; diazepam
Analysis of the Surface Matrix of Copper Cable in Jointing as the Effect of Increasing Current and Heating on Fire Application
Authors: Hasugian Supriedi , Hasan Syafruddin , Rambe Ali Hanafiah , Supiyani  
Published: May 2024

This research aims to analysis of the surface matrix of copper cable in jointing as the imfluence of increasing current and heating on fire experiment. The investigation makes it easier to observe parts of its material of the surface matrix changes of copper cable in jointing as increasing of heating. The study was observed the material surface of general requirements for electrical installations (PUIL) jointed cables and standard NYA ø 1.5 mm2 cables at current load of 50 A and 110A using HIROX digital microscope, XRF (X-ray fluorescence), Raman spectroscopy, and fluke infrared thermometer (FLIR). The results of the study were obtained that the PUILsample jointing heat cable reached of 201oC and 1087oC with heat standard cable of 25.6oC. The copper cable will melt when the cable reached in over heating of 1080oC that it caused the deformation of the cross-sectional area of the cable which are observed in changes in the surface matrix of the burned cable structure. This research can be used as scientific basic for inverstigating the caused of fires and the heat maximum application on the cables.
Analisa Klasifikasi Penyakit Diabetes Dengan Algoritma Neural Network
Authors: Sutrisno Sutrisno , Jupron  
Published: May 2024

Metode yang populer dan efektif untuk mengidentifikasi dan klasifikasi diabetes adalah algoritma deep learning untuk klasifikasi diabetes. Algoritma deep learning, terutama jaringan saraf tiruan juga dikenal sebagai neural networks telah terbukti sangat efektif dalam menangani tugas klasifikasi data medis, seperti diabetes. Dalam penelitian sebelumnya, algoritma neural network digunakan untuk mengklasifikasikan penyakit diabetes, tetapi nilai akurasinya masih di bawah 80,5%. Karena nilai akurasi masih kurang maksimal, penelitian ini bertujuan untuk meningkatkannya. Penggunaan metode pemrosesan yang lebih akurat, kemudian fine tuning hyperparameter dengan algoritma neural network. Beberapa tindakan pembaharuan yang dilakukan dalam penelitian ini merupakan bagian dari serangkaian metode yang digunakan. Tujuan dari pembaharuan ini adalah untuk meningkatkan akurasi yang lebih besar, serta meningkatkan hasil presisi, recall dan F1. Dataset yang digunakan dalam penelitian ini adalah data umum atau sekunder dari kaggle. Penelitian ini dibuat untuk pengetahuan dalam pencegahan penyakit diabetes. Penyakit ini merupakan dengan gejala kadar gula yang sewaktu lebih dari 200 mg/dl dan kadar gula puasa lebih dari 126.mg/dl. Peningkatan kasus diabetes didunia yang sangat tinggi yaitu dari 108 juta meningkat menjadi 422 juta, data ini dari badan Kesehatan dunia pada tahun 1998-2014.
Pengaruh Berbagai Jenis dan Dosis Kompos terhadap Pertumbuhan Bibit Pisang Barangan pada Tahap Aklimatisasi di Lapangan (Transplanting II)
Authors: Eliyanti Eliyanti , Zulkarnain Zulkarnain , Ichwan Budiyati , Situmorang Sonando 
Published: May 2024

This research aimed to investigate the type and dosage of growing media for Barangan banana seedlings during acclimatization in the field (transplanting II). The study was conducted at the Teaching and Research Farm, Faculty of Agriculture, University of Jambi. The trial used a randomized block design with two factors, namely types and doses of compost. The types of compost used were banana pseudostem compost, chicken manure compost, and golden snail compost (kosarmas). While the doses used consisted of 0 mg per kg of planting media, 5 g per kg of planting media, 10 g per kg of planting media, and 15 g per kg of planting media. Each treatment was repeated three times. The results showed that various types and doses of compost did not show significant interactions. Different types and doses of compost media provide good growth of Barangan banana seedlings so that at the age of two months they can be transplanted to the field.The seedlings planted in media with chicken manure compost at a dose of 10 g per kg of planting media tend to showbetter growth performance than other media.
Role of invasive hemodynamics monitoring in sepsis intensive care
Authors: Kozlov I. A. , Ovezov A. M. , Rautbart S. A. 
Published: May 2024

The objective was to study the effect of early planned use of transpulmonary thermodilution (TPTD) and therapeutic measures to stabilize blood circulation on the clinical outcome of sepsis.Materials and methods. The cohort study involved 132 patients with abdominal sepsis with SOFA >7 and blood lactate >1.6 mmol/L. Septic shock was diagnosed in 56 % of patients. TPTD in the early periods of intensive care was began in 53.8 % of patients. Logistic regression and ROC-analysis were used to process the data.Results. Early use of invasive monitoring (OR 2,3715, 95 % CI 1,1107–5,0635, p=0,026, AUC 0.655) and infusion volume >43 ml/kg per day (OR 1.0313, 95 % CI 1.0073–1.0558, p=0.01, AUC 0.677) were predictors of survival in patients with abdominal sepsis. The use of TPTD compared to patients of group II was accompanied by an increase in the daily infusion volume (53.7 [38.1–63.5] vs 38.2 [29.9–47.2], ml/kg per day, p = 0.0001), more frequent use of inotropic drugs (39.4 vs 16.4 %, p = 0.004), and higher level of the inotropic scale (0 [0–4.7] vs 0 [0–0], p = 0.01). There were no differences in the frequency of prescription (57.7 vs 65.5 %, p = 0.376) and dosages (0.2 [0.1–0.4] vs 0.3 [0.2–0.4] μg/kg/min, p = 0.554) of norepinephrine. Twenty-eight-day mortality in groups I and II was 31 and 50.8 % (p = 0.022), hospital mortality was 32.9 and 54.0 % (p = 0.014).Conclusion. When assessed by SOFA > 7 points and lactatemia > 1.6 mmol/L, the onset of TPTD and infusion volume > 43 mL/kg/day increase the likelihood of survival of patients with abdominal sepsis, as a result, 28-day and hospital mortality decrease by 1.6 times. The use of invasive monitoring of central hemodynamics in this clinical situation is accompanied by an increase in the prescription of inotropes by 2.4 times with an unchanged intensity of norepinephrine use.
The long-term effects of the fenestration in patients with extracardiac Fontan circulation—a multicenter Korean cohort study based on national Fontan registry
Authors: Ko Hoon , Song Jinyoung , Chi Sang Ah , Lee Sang-Yun , Kim Soo-Jin , Lee Chang-Ha , Park Chun Soo , Choi Eun Seok , An Hyo Soon , Kang I. Seok , Yoon Ja Kyoung , Baek Jae-Suk , Lee Jae-Young , Lee Joowon , Huh June , Ahn Kyung-Jin , Jung Se Yong , Cha Seul Gi , Kim Yeo-Hyang , Lee Young-Seok 
Published: May 2024

IntroductionThe long-term effects of fenestration in patients with Fontan circulation remain unclear. We aim to evaluate the fenestration impact on early and late outcomes in patients with extracardiac Fontan (ECF) using a propensity score matching analysis.MethodsWe performed an extensive retrospective multicenter clinical data review of the Korean Fontan registry and included 1,233 patients with surgical ECF (779 fenestrated, 454 non-fenestrated). Demographics, baseline, and follow-up data were collected and comprehensively analyzed. Patients were divided into two groups according to the baseline presence or absence of surgical fenestration. Subsequently, patients were sub-divided according to the fenestration status at the last follow-up. Propensity-score matching was performed to account for collected data between the 2 groups using a multistep approach. The primary outcomes were survival and freedom from Fontan failure (FFF). We also looked at postoperative hemodynamics, cardiopulmonary exercise test results, oxygen saturations, and functional status.ResultsAfter propensity-score matching (454 matched pairs), there was no difference in survival or FFF between the 2 groups. However, ECF patients with baseline fenestration had significantly lower oxygen saturation (p = 0.001) and lower functional status (p &lt; 0.001). Patients with fenestration had significantly longer bypass times, higher postoperative central venous pressure, higher postoperative left atrial pressure, and less prolonged pleural effusion in the early postoperative period. The propensity score matching according to the fenestration status at the last follow-up (148 matched pairs) showed that patients with a persistent fenestration had significantly lower oxygen saturation levels (p &lt; 0.001). However there were no intergroup differences in the functional status, survival and FFF.ConclusionsOur results showed no long-term benefits of the Fenestration in terms of survival and FFF. Patients with persistent fenestration showed oxygen desaturation but no difference in exercise intolerance was shown between the 2 groups.
Influence of nonalcoholic fatty liver disease severity on carotid adventitial vasa vasorum
Authors: León-Mengíbar Josep , Sánchez Enric , Herrerías Ferrán , De La Fuente Mari Cruz , Santamaría Maite , Valdivielso José Manuel , Bermúdez-López Marcelino , Castro Eva , Pallarés Judit , Matias-Guiu Xavier , Vilardell Felip , Caixàs Assumpta , Bueno Marta , Martí Raquel , Lecube Albert 
Published: May 2024

IntroductionNonalcoholic fatty liver disease (NAFLD) affects a quarter of the world’s population and encompasses a spectrum of liver conditions, from non-alcoholic steatohepatitis (NASH) to inflammation and fibrosis. In addition, NAFLD also links to extrahepatic conditions like diabetes or obesity. However, it remains unclear if NAFLD independently correlates with the onset and progression of atherosclerosis.Material and methodsThis cross-sectional study aimed to explore the relationship between NAFLD severity, assessed via liver biopsy, and early atherosclerosis using adventitial vasa vasorum (VV) density. It included 44 patients with obesity (33 with steatosis, 11 with NASH) undergoing bariatric surgery.ResultsResults revealed no significant differences in adventitial VV density between steatosis and NASH groups, neither in the mean values [0.759 ± 0.104 vs. 0.780 ± 0.043, P=0.702] nor left-right sides. Similarly, carotid intima-media thickness (cIMT) did not vary between these groups. Additionally, no linear correlation existed between VV density and cIMT. Only gender showed an association with VV density.ConclusionThese findings suggest that NASH severity doesn’t independently drive early atherosclerosis or affects cIMT. Gender might play a role in early atherosclerotic disease in NAFLD, impacting VV density and cIMT. This highlights the need to consider other risk factors when evaluating cardiovascular risk in NAFLD patients.
Current immunotherapeutic approaches to diffuse intrinsic pontine glioma
Authors: Lin Catherine , Smith Christian , Rutka James 
Published: May 2024

Diffuse intrinsic pontine glioma (DIPG) is an aggressive brain tumour that occurs in the pons of the brainstem and accounts for over 80% of all brainstem gliomas. The median age at diagnosis is 6–7 years old, with less than 10% overall survival 2 years after diagnosis and less than 1% after 5 years. DIPGs are surgically inaccessible, and radiation therapy provides only transient benefit, with death ensuing from relentless local tumour infiltration. DIPGs are now the leading cause of brain tumour deaths in children, with a societal cancer burden in years of life lost (YLL) of more than 67 per individual, versus approximately 14 and 16 YLL for lung and breast cancer respectively. More than 95 clinical drug trials have been conducted on children with DIPGs, and all have failed to improve survival. No single or combination chemotherapeutic strategy has been successful to date because of our inability to identify targeted drugs for this disease and to deliver these drugs across an intact blood-brain barrier (BBB). Accordingly, there has been an increased focus on immunotherapy research in DIPG, with explorations into treatments such as chimeric antigen receptor T (CAR-T) cells, immune checkpoint blockades, cancer vaccines, and autologous cell transfer therapy. Here, we review the most recent advances in identifying genetic factors influencing the development of immunotherapy for DIPG. Additionally, we explore emerging technologies such as Magnetic Resonance-guided Focused Ultrasound (MRgFUS) in potential combinatorial approaches to treat DIPG.
Exploring the genetic causal association of TIMP3 on CKD and kidney function: a two-sample mendelian randomization
Authors: Chen Huang , Chen Lixun , Chen Yufeng , Guo Qinyu , Lin Shirong 
Published: May 2024

Background: Numerous studies have demonstrated a positive association between the level of tissue inhibitor of metalloproteinase 3 (TIMP3) and chronic kidney disease (CKD). Nevertheless, whether those associations reflect causal links still to be determined. This study intended to research the causal relationship of TIMP3 with CKD and markers of kidney function, such as creatinine‐based estimated glomerular filtration rate (eGFRcrea), cystatin C‐based estimated glomerular filtration rate (eGFRcys), eGFRcrea in diabetics (eGFRcrea (DM)) and eGFRcrea in non diabetics (eGFRcrea (No DM)).Methods: In this study, we investigated the causal relationships between TIMP3 and CKD and kidney function markers using a two-sample Mendelian randomization (MR) technique. We used summary level datasets for TIMP3 and CKD from genome-wide association studies that we were able to access through the study by Suhre K and Pattaro C.Results: We found that TIMP3 had a significant positive causal effect on the risk of CKD (Inverse variance weighted (IVW):odds ratio (OR):0.962, 95% confidence interval (CI): (0.936-0.988),P:0.005). However TIMP3 levels had no significant effect on risk of eGFRcys (PIVW: 0.114),eGFRcrea (PIVW:0.333). After grouping patients based on their diabetes status, we found that genetically higher levels of TIMP3 had a significant impact on eGFRcrea in participants without diabetes (OR:1.003,95%CI (1.001-1.006),P IVW:0.007), but not in participants with diabetes (PIVW = 0.057). Heterogeneity and pleiotropy analyses were carried out to verify the accuracy of the MR findings. Their findings were all not statistically significant.Conclusion: Our study suggests that TIMP3 may be causally associated with CKD and eGFRcrea (No DM)in people of European ancestry. Strategies aimed to increase TIMP3 levels may provide new ways to delay the deterioration of renal function.
Clinical biomarkers for thyroid immune-related adverse events in patients with stage III and IV gastrointestinal tumors
Authors: Xing Na , Liu Jing , Hou Lin , Zhao Yue , Ma Hongfang , Wang Fujun , Guo Zhanjun 
Published: May 2024

BackgroundThyroid immune-related adverse events (irAEs) associated with immune checkpoint inhibitor (ICI) treatment appear to correlate with a better prognosis. We aimed to investigate clinical biomarkers associated with thyroid irAEs.MethodsWe retrospectively analyzed data from 129 patients receiving programmed cell death protein 1 (PD-1) inhibitors for stage III and IV gastrointestinal tumors. Patients were divided into two groups: “thyroid irAEs” group and “no thyroid irAEs” group. We compared continuous variables using Mann–Whitney U and Kruskal–Wallis tests and categorical variables using Pearson’s chi–square test. Survival curves were generated using the Kaplan–Meier method, and associations between clinical features and thyroid irAEs were assessed using univariate and multivariate logistic regression models. Associations for thyroid irAEs and outcomes [progression-free survival (PFS), overall survival (OS)] of the patients were performed with a Cox proportional hazard model.ResultsA total of 129 patients, including 66 gastric cancer, 30 esophageal squamous cell carcinoma, and 33 hepatocellular carcinoma (HCC), were involved in this analysis with 47 cases of thyroid irAEs occurrence. The Cox proportional hazard model analysis confirmed the extended PFS [hazard rate (HR) = 0.447, 95% confidence interval (CI): 0.215 to 0.931, p = 0.031] and OS (HR = 0.424, 95% CI: 0.201 to 0.893, p = 0.024) for thyroid irAEs group when compared with those of the no thyroid irAEs group. Association between thyroid irAEs and clinical characteristics at baseline was analyzed subsequently by univariate analysis. Higher body mass index (p = 0.005), increased eosinophil count (p = 0.014), increased lactate dehydrogenase (p = 0.008), higher baseline thyroid stimulating hormone (TSH) (p = 0.001), HCC (p = 0.001) and increased adenosine deaminase (ADA) (p = 0.001) were linked with thyroid irAEs occurrence. The multivariable logistic regression model indicated that ADA [odds rate (OR) = 4.756, 95% CI: 1.147 to 19.729, p = 0.032] was independently associated with thyroid irAEs occurrence.ConclusionsIncreased baseline level of ADA was associated with thyroid irAEs occurrence in patients with advanced gastrointestinal tumors who received ICI treatment. In the case of abnormal ADA, attention should be paid to the risk of thyroid irAEs.
Lower thermal tolerance restricts vertical distributions for juvenile albacore tuna (Thunnus alalunga) in the northern limit of their habitats
Authors: Matsubara Naoto , Aoki Yoshinori , Aoki Akiko , Kiyofuji Hidetada 
Published: May 2024

IntroductionEvaluating the thermal tolerance of commercially valuable tuna species and their behavioral responses to the limits of this tolerance is essential for evaluating the effects of changes in water temperature driven by global climate change on their distribution and fisheries. We aimed to identify the lower thermal tolerance (Tmin) of juvenile albacore tuna (ALB) and evaluate their behavioral response to Tmin by focusing on wild behavior in the northern distributional limit. Additionally, we investigated how vertical behavior is linked to the vulnerability of ALB to Japanese longline (LL) and pole-and-line (PL) fisheries.MethodsWe explored the swimming depths and water temperatures of four previously reported tagged individuals migrating from subtropical to temperate areas and identified Tmin and its depths in the water column as unfavorable depths (DTmin). To investigate the spatial patterns of ALB fishery grounds for LL and PL fisheries, we analyzed hotspots specific to each type of gear using the historical Japanese fishery logbook for both fisheries.ResultsComparisons of the fishery grounds between the two fisheries revealed that PL hotspots appeared in the northern areas, while LL hotspots were in the southern regions. We also discovered that the vertical distribution of ALB became shallow in high-latitude areas, which were strongly affected by DTmin shallowing at high latitudes.DiscussionThese results provide evidence of a behavioral response among juvenile ALB that avoids Tmin by remaining at the surface. We discuss the implications of the results for latitudinal changes in the vulnerability of ALB to fisheries in terms of the overlapping depth between ALB vertical habitats and the gear-setting depth for each fishery.
Factors influencing survival and mortality among adult Aboriginal Australians with bronchiectasis—A 10-year retrospective study
Authors: Heraganahally Subash S. , Gibbs Claire , Ravichandran Shiidheshwar J. , Erdenebayar Davaadorj , Abeyaratne Asanga , Howarth Timothy 
Published: May 2024

BackgroundThe prevalence of bronchiectasis among adult Aboriginal Australians is higher than that of non-Aboriginal Australians. However, despite evidence to suggest higher prevalence of bronchiectasis among Aboriginal people in Australia, there is sparce evidence in the literature assessing clinical parameters that may predict survival or mortality in this population.MethodsAboriginal Australians residing in the Top End Health Service region of the Northern Territory of Australia aged &gt;18 years with chest computed tomography (CT) confirmed bronchiectasis between 2011 and 2020 were included. Demographics, body mass index (BMI), medical co-morbidities, lung function data, sputum microbiology, chest CT scan results, hospital admissions restricted to respiratory conditions and all-cause mortality were assessed.ResultsA total of 459 patients were included, of whom 146 were recorded deceased (median age at death 59 years). Among the deceased cohort, patients were older (median age 52 vs. 45 years, p = 0.023), had a higher prevalence of chronic obstructive pulmonary disease (91 vs. 79%, p = 0.126), lower lung function parameters (median percentage predicted forced expiratory volume in 1 s 29 vs. 40%, p = 0.149), a significantly greater proportion cultured non-Aspergillus fungi (65 vs. 46%, p = 0.007) and pseudomonas (46 vs. 28%, p = 0.007) on sputum microbiology and demonstrated bilateral involvement on radiology. In multivariate models advancing age, prior pseudomonas culture and Intensive care unit (ICU) visits were associated with increased odds of mortality. Higher BMI, better lung function on spirometry, prior positive sputum microbiology for Haemophilus and use of inhaled long-acting beta antagonist/muscarinic agents may have a favourable effect.ConclusionThe results of this study may be of use to stratify high risk adult Aboriginal patients with bronchiectasis and to develop strategies to prevent future mortality.