bluuebunny/crossref_metadata_2025_split huggingface dataset:
Fire the Big Box!?
Authors: Zeller Thomas L , Palzer Thomas J , Tressler Andrew D 
Published: May 2011

ABSTRACT
Durable Glove, Inc. faces a common problem. The traditional reporting system does not capture a valid measure of customer profitability. The reporting structure no longer captures how customers consume resources differently throughout the value chain. Their value chain begins in Asia and ends at the United States (U.S.) retail storefront. Management is searching for a better reporting solution in their efforts to increase shareholders' value.
In this case, you make an important recommendation to Durable Glove's management. Should management decide to keep or to fire the Big Box retailer? You base the recommendation upon allocations and customer profitability reports that show how customers consume resources differently. The spreadsheet template1 that complements this case provides a structure for the allocations and reports. The completed reports capture an approximation of Durable Glove's customer profitability. You evaluate the reports and make a recommendation to improve Durable Glove's customer profitability, which focuses on keeping or firing the Big Box customer.
Generic Health Care Hospital: The Road to an Integrated Risk Management System
Authors: Burnaby Priscilla , Hass Susan , O'Reilly Anthony 
Published: May 2011

ABSTRACT
Three related areas—Sarbanes-Oxley's requirements for control reports, COSO's Enterprise Risk Management (ERM) suggested control structure, and the enterprise risk management process—need more classroom materials to demonstrate to students the importance of a cohesive risk analysis process and control system for an organization to be successful and competitive. This case requires students to understand the importance of risk management, the implementation of an internal control structure, and a controls review in a hospital setting for compliance and administration of Medicare and Medicaid costs. Although the facts of the case are based on professionals' consulting experiences, the hospital in the case is fictional and is a composite of many client engagements. This case is appropriate for an analysis for potential fraud, a Sarbanes-Oxley Act (SOX) review of risks and internal controls, assessment of compliance with laws and regulations, and implementation of an enterprise-wide risk management system.
Evaluation of the effect of force direction on stationary anchorage success of mini-implant with a lever-arm–shaped upper structure
Authors: Park Ki-Ho , Lee Eun-Man , Shin Seung-il , Kim Seong-Hun , Park Young-Guk , Kim Su-Jung 
Published: May 2011

Abstract

Objective:
To compare the effect of clockwise and counterclockwise torque on the primary stability of a mini-implant with a lever-arm–shaped upper structure.

Materials and Methods:
Twenty-four white rabbits were used for this study. Two screw-type mini-implants were placed in each tibia. In all, 96 screws were inserted. Two weeks later, a 2-N force was applied to the mini-implants without an upper structure in eight rabbits (control group). The mini-implants of the other 16 rabbits were loaded with an upper structure (experimental group). In the experimental group, the two left mini-implants were loaded in a clockwise direction (CW group) and the two right implants were loaded in a counterclockwise direction (CCW group). The rabbits were sacrificed at 1 week or 8 weeks after loading in both control and experimental groups. The removal torque value (RTV) was measured in 15 of 16 mini-implants in each group and the remaining implant was processed for histologic examination.

Results:
At 1 week there were no significant differences in the mean RTV between the control, CW, and CCW groups. At 8 weeks, the RTV was higher in the control and experimental groups than in the respective 1-week groups. At 8 weeks, there were no significant differences in the RTV between the control and CW groups, but the CCW group showed a lower RTV.

Conclusions:
CCW torque can decrease the stability of a mini-implant, whereas a CW torque has no effect.
Mutations of the Same Conserved Glutamate Residue in NBD2 of the Sulfonylurea Receptor 1 Subunit of the KATP Channel Can Result in Either Hyperinsulinism or Neonatal Diabetes
Authors: Männikkö Roope , Flanagan Sarah E. , Sim Xiuli , Segal David , Hussain Khalid , Ellard Sian , Hattersley Andrew T. , Ashcroft Frances M. 
Published: May 2011

OBJECTIVE
Two novel mutations (E1506D, E1506G) in the nucleotide-binding domain 2 (NBD2) of the ATP-sensitive K+ channel (KATP channel) sulfonylurea receptor 1 (SUR1) subunit were detected heterozygously in patients with neonatal diabetes. A mutation at the same residue (E1506K) was previously shown to cause congenital hyperinsulinemia. We sought to understand why mutations at the same residue can cause either neonatal diabetes or hyperinsulinemia.

RESEARCH DESIGN AND METHODS
Neonatal diabetic patients were sequenced for mutations in ABCC8 (SUR1) and KCNJ11 (Kir6.2). Wild-type and mutant KATP channels were expressed in Xenopus laevis oocytes and studied with electrophysiological methods.

RESULTS
Oocytes expressing neonatal diabetes mutant channels had larger resting whole-cell KATP currents than wild-type, consistent with the patients’ diabetes. Conversely, no E1506K currents were recorded at rest or after metabolic inhibition, as expected for a mutation causing hyperinsulinemia. KATP channels are activated by Mg-nucleotides (via SUR1) and blocked by ATP (via Kir6.2). All mutations decreased channel activation by MgADP but had little effect on MgATP activation, as assessed using an ATP-insensitive Kir6.2 subunit. Importantly, using wild-type Kir6.2, a 30-s preconditioning exposure to physiological MgATP concentrations (&gt;300 µmol/L) caused a marked reduction in the ATP sensitivity of neonatal diabetic channels, a small decrease in that of wild-type channels, and no change for E1506K channels. This difference in MgATP inhibition may explain the difference in resting whole-cell currents found for the neonatal diabetes and hyperinsulinemia mutations.

CONCLUSIONS
Mutations in the same residue can cause either hyperinsulinemia or neonatal diabetes. Differentially altered nucleotide regulation by NBD2 of SUR1 can explain the respective clinical phenotypes.
Identifications à l'autre différent et projections déshumanisantes
Authors: André-Fustier Francine 
Published: May 2011

Résumé Le bébé se construit en différenciant l’environnement humain et l’environnement non humain (minéral, végétal, animal) grâce à un environnement primaire suffisamment bon, c’est-à-dire suffisamment stable et en continuité avec ses besoins. En cas de rupture dans cet environnement (troubles somatiques graves, hospitalisations) le bébé tente de rester en contact avec des éléments non humains de son environnement, ce qui engendre des pathologies graves entraînant une dé-différenciation animé/inanimé ou humain/non humain. Il importe que l’entourage, à qui le bébé transmet ses angoisses, ne l’enferme pas dans ses manifestations animales ou plus généralement non humaines.
Grasping et casting, des modalités du lien à l'intérieur d'un couple
Authors: Bianchini Barbara , Dallanegra Laura , Vitalini Lidia 
Published: May 2011

Résumé Dans ce travail, les auteurs essayent d’approfondir la théorisation de A. Ferro concernant d’une part le grasping , réflexe primaire d’agrippement propre à notre espèce, et d’autre part le casting , tentative d’exprimer des parties muettes ou clivées, à travers une recherche de personnages adaptés pour jouer un rôle. Ces deux aspects peuvent aider à comprendre comment se forme et comment fonctionne une relation de couple. Le choix du partenaire peut renvoyer au casting , autrement dit à la tentative, en formant un couple avec une autre personne, de donner une voix à des parties muettes ou à des aspects non développés ou clivés de la personnalité. La maturation des individus au sein d’un couple peut-elle se faire par la renonciation, dans la limite du possible, à l’agrippement (grasping) à ce qui est déjà connu ? Peut-elle se faire grâce à la reconnaissance de la subjectivité de l’autre et grâce à un plus grand contact avec des zones inexplorées de notre personnalité, comme dans une tentative de donner une voix à de nouveaux personnages, en étant des « metteurs en scène » plus conscients ? Enfin, la thérapie psychanalytique de couple peut-elle aider à cette opération de partielle intégration d’aspects clivés, pour conduire à une plus grande capacité d’être en relation avec l’autre ? À travers des réflexions et des exemples cliniques le travail approfondit ces hypothèses.
Les modèles de management : une étude exploratoire des discours des organisations
Authors: Bensebaa Faouzi , Autissier David 
Published: May 2011

Résumé Cette recherche étudie les questions majeures traitées par les modèles de management et la façon dont les organisations les opérationnalisent. Méthodologiquement, le travail mené s’appuie sur l’analyse de onze modèles de management au moyen de données secondaires. Les résultats obtenus laissent entendre que les modèles de management constituent un outil d’organizing, fondé sur quatre variables clés - l’implication des individus ; la recherche de performance ; les valeurs et les principes éthiques ; l’expertise du métier - reflétant la combinaison des approches axées sur le management scientifique, les relations humaines et la structure, ainsi que celles fondées sur la légitimité et la normalisation.
Vygostki, la carriérologie profane et le succès de carrière
Authors: Pralong Jean 
Published: May 2011

Résumé La littérature sur les carrières est largement organisée autour de l’opposition entre carrières subjectives et carrières objectives. Les travaux de ceux qui, depuis Vygotski, ont pris l’activité comme unité molaire d’analyse, permettent de dépasser cette opposition et d’analyser comment les individus se sont appropriés les transformations en cours pour saisir quelles sont les logiques qui les animent. Grâce à l’examen d’extraits de 21 cas, ce texte propose de définir et d’illustrer la notion de « carriérologie profane » et ses relations avec l’activité et la subjectivité. Il mobilise et décrit la technique des événements critiques de carrière. Elle permet d’observer la carriérologie profane au ras de l’activité et de comprendre comment les sujets la mobilisent. Elle rend possible l’analyse de l’entremêlement du travail et de la carrière ou des enjeux subjectifs et objectifs des parcours. Elle ouvre un accès, enfin, aux moments de développement et à leurs ressources.
Le pétrole du Moyen-Orient est-il géo- politiquement si précieux ? Réflexions autour d'une contestable centralité économique, stratégique et énergétique
Authors: Encel Frédéric 
Published: May 2011

Résumé Il est communément admis que le pétrole du Moyen-Orient constitue l’un des grands enjeux géopolitiques internationaux. Est-ce si évident ? En scrutant sérieusement les grandes évolutions du monde depuis le début du XXè siècle, on s’aperçoit que l’or noir abondant de cette région instable ne fut que rarement l’objectif d’Etats prédateurs, et presque jamais le moteur des tensions et des guerres internes que connut le Moyen-Orient. En outre, la concurrence non seulement des ressources pétrolières d’autres zones mais aussi des produits énergétiques alternatifs, pourrait à terme rendre moins décisif encore le précieux liquide de cette région.
Le développement énergétique en Turquie : quels effets en attendre ?
Authors: Schalck Christophe 
Published: May 2011

Résumé L’objet de cette étude est d’identifier la problématique énergétique en Turquie et d’analyser les conséquences sur son économie. L’étude se base sur une analyse couvrant la période 1960-2007. L’article montre un risque économique du fait d’une relation entre la consommation énergétique et le revenu national. Il montre que la position de « hub » a un enjeu géopolitique et économique puisqu’elle est un élément moteur pour l’industrie même si cela implique une disparité régionale.
Evidence thatCd101Is an Autoimmune Diabetes Gene in Nonobese Diabetic Mice
Authors: Rainbow Daniel B. , Moule Carolyn , Fraser Heather I. , Clark Jan , Howlett Sarah K. , Burren Oliver , Christensen Mikkel , Moody Val , Steward Charles A. , Mohammed Javid P. , Fusakio Michael E. , Masteller Emma L. , Finger Erik B. , Houchins J. P. , Naf Dieter , Koentgen Frank , Ridgway William M. , Todd John A. , Bluestone Jeffrey A. , Peterson Laurence B. , Mattner Jochen , Wicker Linda S. 
Published: May 2011

AbstractWe have previously proposed that sequence variation of the CD101 gene between NOD and C57BL/6 mice accounts for the protection from type 1 diabetes (T1D) provided by the insulin-dependent diabetes susceptibility region 10 (Idd10), a &lt;1 Mb region on mouse chromosome 3. In this study, we provide further support for the hypothesis that Cd101 is Idd10 using haplotype and expression analyses of novel Idd10 congenic strains coupled to the development of a CD101 knockout mouse. Susceptibility to T1D was correlated with genotype-dependent CD101 expression on multiple cell subsets, including Foxp3+ regulatory CD4+ T cells, CD11c+ dendritic cells, and Gr1+ myeloid cells. The correlation of CD101 expression on immune cells from four independent Idd10 haplotypes with the development of T1D supports the identity of Cd101 as Idd10. Because CD101 has been associated with regulatory T and Ag presentation cell functions, our results provide a further link between immune regulation and susceptibility to T1D.
Netting Neutrophils Induce Endothelial Damage, Infiltrate Tissues, and Expose Immunostimulatory Molecules in Systemic Lupus Erythematosus
Authors: Villanueva Eneida , Yalavarthi Srilakshmi , Berthier Celine C. , Hodgin Jeffrey B. , Khandpur Ritika , Lin Andrew M. , Rubin Cory J. , Zhao Wenpu , Olsen Stephen H. , Klinker Matthew , Shealy David , Denny Michael F. , Plumas Joel , Chaperot Laurence , Kretzler Matthias , Bruce Allen T. , Kaplan Mariana J. 
Published: May 2011

Abstract
An abnormal neutrophil subset has been identified in the PBMC fractions from lupus patients. We have proposed that these low-density granulocytes (LDGs) play an important role in lupus pathogenesis by damaging endothelial cells and synthesizing increased levels of proinflammatory cytokines and type I IFNs. To directly establish LDGs as a distinct neutrophil subset, their gene array profiles were compared with those of autologous normal-density neutrophils and control neutrophils. LDGs significantly overexpress mRNA of various immunostimulatory bactericidal proteins and alarmins, relative to lupus and control neutrophils. In contrast, gene profiles of lupus normal-density neutrophils do not differ from those of controls. LDGs have heightened capacity to synthesize neutrophils extracellular traps (NETs), which display increased externalization of bactericidal, immunostimulatory proteins, and autoantigens, including LL-37, IL-17, and dsDNA. Through NETosis, LDGs have increased capacity to kill endothelial cells and to stimulate IFN-α synthesis by plasmacytoid dendritic cells. Affected skin and kidneys from lupus patients are infiltrated by netting neutrophils, which expose LL-37 and dsDNA. Tissue NETosis is associated with increased anti-dsDNA in sera. These results expand the potential pathogenic roles of aberrant lupus neutrophils and suggest that dysregulation of NET formation and its subsequent responses may play a prominent deleterious role.
An aggregation model reduction method for one‐dimensional distributed systems
Authors: Linhart Andreas , Skogestad Sigurd 
Published: May 2011

AbstractA method for deriving reduced dynamic models of one‐dimensional distributed systems is presented. It inherits the concepts of the aggregated modeling method of Lévine and Rouchon originally derived for simple staged distillation models and can be applied to both spatially discrete and continuous systems. The method is based on partitioning the system into intervals of steady‐state systems, which are connected by dynamic aggregation elements. By presolving and substituting the steady‐state systems, a discrete low‐order dynamic model is obtained. A characteristic property of the aggregation method is that the original and the reduced model assume identical steady states. For spatially continuous systems, the method is an alternative to discretization methods like finite‐difference and finite‐element methods. Implementation details of the method are discussed, and the principle is illustrated on three example systems, namely a distillation column, a heat exchanger, and a fixed‐bed reactor. © 2011 American Institute of Chemical Engineers AIChE J, 2012
Input reconstruction for statistical‐based fault detection and isolation
Authors: Schubert Udo , Kruger Uwe , Wozny Günter , Arellano‐Garcia Harvey 
Published: May 2011

AbstractIn this work, an input reconstruction scheme for detecting and isolating sensor, actuator, and process faults is proposed. The scheme uses model‐based and statistical‐based FDI methods, which yields an improved analysis of abnormal operation conditions in chemical processes. The main advantage of the proposed approach over existing works lies in the reconstruction of system inputs and the subsequent estimation of fault signatures. This advantage is demonstrated through simulation examples and the analysis of recorded process data from a reactive batch distillation column. © 2011 American Institute of Chemical Engineers AIChE J, 2012
Preparation of a novel phthalimidomethylated polysulfone/unmodified polysulfone blend affinity membrane and applications for removal of p‐nitrophenol
Authors: Sun Yanwei , Wang Bing 
Published: May 2011

AbstractA novel phthalimidomethyl polysulfone (PIPSf)/polysulfone(PSf) blend affinity membrane was prepared and applied for the removal of p‐nitrophenol from aqueous solutions. In this work, the chloromethylated polysulfone (CMPSf) was used to introduce phthalimido groups onto the polysulfone backbone by Gabriel reaction. The polymers can be easy to phthalimidomethylate to different degrees by control of the reaction temperature and time. Structures of the resulting polymers were confirmed by FT‐IR. The obtained polymers showed good solubility in dimethylformamide, dimethylacetamide and formed the affinity membrane blending with polysulfone at different blend compositions by the phase‐inversion method. Thus the properties of films were characterized with respect to water flux, pore size, and porosity. The surface and cross‐sectional views of the blend membranes were analyzed by scanning electron microscopy (SEM). The research on treatment of removal p‐nitrophenol was carried out by affinity membrane process. The adsorption capacity increased with increasing the initial concentration of p‐nitrophenol in aqueous solution, and the adsorption isotherm fitted the Freundlichmodel well. © 2011 Wiley Periodicals, Inc. J Appl Polym Sci, 2011
Control release of some pesticides from starch/(ethylene glycol‐co‐methacrylic acid) copolymers prepared by γ‐irradiation
Authors: Abd El‐Mohdy H. L. , Hegazy E. A. , El‐Nesr E. M. , El‐Wahab M. A. 
Published: May 2011

AbstractStarch/(Ethylene glycol‐co‐Methacrylic acid) [Starch/(EG‐co‐MAA)] hydrogels were designed for controlled delivery of pesticides, such as Fluometuron (FH); Thiophanate Methyl (TF) and Trifluralin (TI) which are use in the agricultural field. The delivery device was prepared by using γ‐irradiation and was characterized by FTIR, DSC, and SEM. The swelling behavior of hydrogels as a function of copolymer composition and irradiation dose was detected. This article discusses the swelling kinetics of polymer matrix and release dynamics of Trifluralin from hydrogels for the evaluation of the diffusion mechanism and diffusion coefficients. The values of the diffusion exponent ‘n’ for both the swelling of hydrogels and the release of Trifluralin from the hydrogels have been observed between 0.56 and 0.86 when the MAA content in the polymers was varied from 20 to 80 wt %, respectively. It is inferred from the values of the ‘n’ that non‐Fickian diffusion mechanism has occurred for different EG/MAA compositions. The release rate from matrices prepared under different conditions was studied to determine which factors have the most affect and control over the hydrogel matrix release property. The preparation conditions such as EG/MAA hydrogel composition, pesticide concentration, type of pesticide and irradiation dose greatly affect the pesticide release rate, which also influenced by the pH and temperature of the matrix‐surrounding medium. The pesticide release rate decreased as the irradiation dose and pH increased, but it increased as the MAA content, pesticide concentration and temperature increased. The release rate of Trifluralin is the highest one, whereas the Fluometuron is the lowest. The properties of the prepared hydrogels may make them acceptable for practical use as bioactive controlled release matrices. © 2011 Wiley Periodicals, Inc. J Appl Polym Sci, 2011
Multicomponent antimicrobial transparent polymer coatings
Authors: Chan Charis M. N. , Cheng H. S. , Djurišić Aleksandra B. , Ng A. M. C. , Leung Frederick C. C. , Chan Wai Kin 
Published: May 2011

AbstractTransparent poly vinyl alcohol (PVA) based coatings with antimicrobial activity against a wide range of microorganisms have been prepared. The films have been prepared by spincoating a mixture of PVA, ammonium dichromate and metal (zinc or silver) precursor from water solutions, and then rendered insoluble by crosslinking under UV illumination. Antimicrobial activity has been tested against different bacteria and fungi, such as Bacillus atrophaeus, Bacillus megaterium, Staphylococcus aureus, Enterococcus faecium, Pseudomonas aeruginosa, Salmonella enterica, Escherichia coli, Neurospora crassa, and Saccharomyces cerevisiae. It was found that combining the zinc and silver precursors resulted in films which had excellent antimicrobial activity and at the same time exhibited superior environmental stability compared to films containing prepared with single metal precursor. © 2011 Wiley Periodicals, Inc. J Appl Polym Sci, 2011
Chick Amniogenesis is Mediated by an Actin Cable
Authors: Tipping Nuala , Wilson David 
Published: May 2011

AbstractThis study examined the process of chick amniogenesis to determine whether the actin cable mechanism operating during amnion wound repair is a recapitulation of developmental events. Staining of the developing amnion with fluorescein isothiocyanate‐labeled phalloidin indicated the presence of an actin cable in the amniotic head fold, which persisted through to the closure of the amnion. Transmission electron microscopy of the developing amnion revealed linearly arranged actin microfilaments in the elongated cells at the leading edge of the amnion, adjacent to either side of a nodule of numerous cells at the point of midline fusion. A mesh of cytoplasmic actin filaments was seen dispersed throughout the accumulated cells of the nodule. Lamellapodia were absent suggesting that cell crawling is not involved in amniogenesis. Addition of an enzyme inhibitor of Rho, cell‐permeable C3 transferase, to the surface of the developing amnion prior to closure appeared to inhibit amniogenesis at the early embryonic stages. Anat Rec, 2011. © 2011 Wiley‐Liss, Inc.