bluuebunny/crossref_metadata_2025_split huggingface dataset:
Note on the toxicity and the chemotherapeutic effectiveness of vitamin c derivative of bis (4‐aminophenyl)‐sulfone in guinea pigs infected with tuberculosis
Authors: Sah Peter P. T. 
Published: September 2010

AbstractVitamin C derivative of bis(4‐aminophenyl)‐sulfone was found to be moderately active in suppressing experimental tuberculosis in guinea pigs. The new sulfone drug is well absorbed, evenly distributed in the tissues, of sufficiently long retention in the animal body and does not possess too high toxicity, acute or chronic.
The interaction of phosphorus trichloride and benzaldehyde in presence of acetic anhydride
Authors: Atherton F. R. , Clark V. M. , Todd A. R. 
Published: September 2010

AbstractThe action of halogens on trivalent compounds of phosphorus has been generalised, and a new interpretation of the formation of α‐hydroxyphosphonic acids (RCHOH.PO(OH)2) by the action of phosphorus trichloride on carbonyl compounds examined on this basis.
Thermochemical investigations on arylethenes: I. Heats of combustion of phenylethenes
Authors: Coops J. , Hoijtink G. J. 
Published: September 2010

AbstractThe heats of combustions of all the phenylethenes except styrene Measured by E. J. Prosen, R. Gilmont and F. D. Rossini, J. Research Natl. Bur. Standards 34, 65 (1945); D. E. Roberts, W. W. Walton and R. I. Jessup, idem 38, 627 (1947).
), were measured. The values (UR) given in the table below refer to the isothermisochore reaction: CmHn + (m + 1/4 n) O2 → m CO2(g) + 1/2 n H2O(l) at 30 atm O2 and 25° C.
Urinary excretion of 17‐ketosteroids in normal human subjects under conditions of fatigue
Authors: Dingemanse E. , Veld L. G. Huis In 'T 
Published: September 2010

Abstract
The excretion of 17‐ketosteroids was determined in three normal men before, during and after extremely fatiguing work. The figures reported refer to 8‐hour periods.
It was ascertained that 17‐ketosteroid excretion was increased during fatiguing work.
Some reactions of picolyllithium
Authors: Gilman Henry , Towle J. Lewis 
Published: September 2010

AbstractPicollyllithium and picolylmagnesium bromide and iodide, unlike their structurally analogous compounds benzylmagnesium chloride and benzyllithium, react with acetyl chloride and wi ethylene oxide in the normal manner.Some anionic forms which may be involved have been considered.
Some remarks on the structure of the lithium compounds of α‐picoline and α,α′‐lutidine
Authors: Sixma F. L. J. , de Jong J. I. 
Published: September 2010

AbstractThe distribution of the α‐electrons in the α‐picolyl and in the α,α′ lutidylion is calculated by wave mechanics. On the basis of the results of this calculation some properties of the lithium compounds of α‐picoline and α,α′‐lutidine are discussed.
The Raman spectra of di‐, tri‐ and tetrathionate ions in aqueous solutions
Authors: Gerding H. , Eriks K. 
Published: September 2010

AbstractFrequency shifts and depolarization factors for the Raman lines of the S2O6“ion in aqueous solution are given. Three p and three dp lines are found. This proves ‐ in agreement with a conclusion drawn already by Duval and Lecomte from other evidence ‐, that the S2O6″ion has the staggered ethane‐like configuration with symmetry D3d. A few calculations for this ion are communicated. The Raman spectra of S3O6″ and S4O6″ in aqueous solution are determined. Incomplete polarization measurements for the Raman lines of the tetrathionate ion are given.
The raman spectrum of trichloroacrylic acid CCl2  CCl . COOH
Authors: Gerding H. , Haring H. G. 
Published: September 2010

AbstractThe Raman spectrum of liquid trichloroacrylic acid at 80° C is communicated. From this spectrum and from a comparison with the infrared absorption of solid trichloroacrylic acid and a number of salts, it is concluded that an equilibrium between monomeric and (probably) dimeric molecules exists in the liquid. No signs of an appreciable ionization have been found. The Raman spectrum of acrylic acid is briefly discussed.
Thermodynamic properties of mixtures of alkanes differing in chain length. II. Vapour pressures
Authors: van der Waals J. H. , Hermans J. J. 
Published: September 2010

AbstractA description is given of a micro‐method for the determination of vapour pressures at elevated temperatures. In this method the vapour over the solution is brought into thermodynamic equilibrium with that of the pure volatile component at a lower temperature. The pressure is indirectly determined by the accurate measurement of the difference in temperature between the solution and the pure volatile component.With this apparatus we have determined the vapour pressure of heptane in mixtures with dotriacontane at 73° C, and in mixtures with a polythene fraction at 109° C. In another apparatus the vapour pressure of 2,2,4‐trimethyl pentane‐hexadecane mixtures has been investigated at 24.9° C. The thermodynamic consequences of the heats of mixing and vapour pressures measured are discussed.
Etudes dans la Sêrie du Thiophène. V. ) Nouvelles cétones thiophéniques et leurs dérivés
Authors: Buu‐Hoï Ng. Ph. , Hoán Ng. , Xuong Ng. D. 
Published: September 2010

AbstractDans ce travail, les auteurs décrivent une série de cétones thiophéniques nouvelles, provenant de réactions de Friedel‐Crafts entre d'une part, le thiophène, le 2‐thiotolène, le 2,5‐thioxène, le 2‐chlorothiophène et le 2‐bromothiophène, et d'autre part, des chlorures d'acides aromatiques et d'acides thiophéniques porteurs de substituants variés. Les chlorures d'acides thiophéniques ont été également condensés avec le thioanisole, le thiophénétole, le biphényle, et le fluorène selon Friedel‐Crafts, et avec l'indole et le 2‐méthylindole selon Oddo. En vue d'études biologiques, certaines des cétones ainsi obtenues ont été transformées en α,β,β‐triaryléthénes; les cétones possédant des groupements méthoxyles ont été déméthylées en hydroxycétones, et ces dernières soumises à la réaction de Claisen (allylation puis transposition en orthoallyl‐hydroxycétones). La condensation de plusieurs thiophènes substitués avec les anhydrides phtalique et succinique a été étudiée, et les produits de réaction font l'objet d'études biologiques (effets sur les végétaux).
Investigations on quinones and quinone‐derivatives ). Preparation and antibiotic properties of some substituted p‐benzo‐and p‐toluquinones, hydroquinones and hydroquinone diesters
Authors: Huisman H. O. 
Published: September 2010

AbstractThe preparation of a number of substituted p‐benzo‐ and p‐toluquinones, hydroquinones and hydroquinone di‐esters is described.The antibiotic properties of these compounds have been tested in vitro against a yeast, various moulds and Gram‐positive and Gram‐negative micro‐organisms.The toxicity has been determined in white mice by oral administration and by intraperitoneal injection.The chemotherapeutic activity has been investigated in white mice injected with a lethal dose of pneumococci.
A polarographic determination of vitamin‐K3 (2‐methyl‐1,4‐naphthoquinone) in prepared feeds
Authors: Onrust H. , Wöstmann B. 
Published: September 2010

AbstractIn this article a description is given of a quantitative polarographic method of determining the synthetic vitamin‐K3 (2‐methyl‐1,4‐naphthoquinone).A non‐aqueous polarographic medium is made up from the petroleum ether extract of the prepared feeds which have been enriched with vitamin‐K3. The concentration of the vitamin‐K3 in this medium, which can dissolve about 8 per cent, by volume of wheat germ oil, can be determined polarographically with the help of an internal standard.The standard deviation of a determination in a sample with a content of about 80 γ/gram is equal to 2.6 γ, while the quantities of vitamin‐K2 added are in most cases recovered almost completely.
Synthèse de Stérols à chaînes latérales variées (II)
Authors: de Vries Harmen , Backer H. J. 
Published: September 2010

AbstractD'après le procédé décrit dans le premier mémoire 1) les auteurs ont synthétisé trois nouveaux stérols avec une chaîne latérale renfermant 8, 9 et 12 atomes de carbone. Plusieurs esters de ces stérols donnent des cristaux liquides.
The antitubercular activity of azo dyes. I. Bisazo dyes derived from tetrazotized bis(4‐aminophenyl)‐sulfone and various coupling components
Authors: Sah Peter P. T. 
Published: September 2010

AbstractIn order to find out whether the chemotherapeutic properties of bisazo dyes derived from bis(4‐aminophenyl)‐sulfone are due to the dyes themselves or to the amine tetrazotized (reduction product of the dye), thirty bisazo dyes were prepared by condensing tetrazotized bis(4‐aminophenyl)‐sulfone with various types of coupling components.Thein vitroactivity of these dyes againstM. Tb.was studied. The most active ones were those derived from 1,3‐diaminobenzene, meta‐aminobenzoic acid, salicylic acid, and 8‐hydroxy‐quinoline. They inhibited the growth of this micro‐organism completely at a concentration of 2 mg per 10 cm3culture. The derivative from meta‐amino‐benzoic acid was still strongly bacteriostatic at a concentration of 0.2 mg per 10 cm3culture.(3) Nine of the above bisazo dyes representing different types were also tested chemotherapeutically. Only three of them (derivatives from meta‐phenylene diamine, salicylic acid and H acid) were found to be as effective as sulfanilamide inStreptococcus hemolyticusinfected mice. The dye from meta‐phenylene diamine was also as effective as sulfadiazine in mice infected with McGovern, normal Type IPneumococcus. They were ineffective against tetanus toxemia, influenza virus, and rabic virus in mice.Five of these dyes were tested in vitro against ameba. Two of them (derivatives from 3,5‐diamino‐benzoic acid and 2‐methyl‐1,4‐naphthohydroquinone) were as effective as chloroquine standard. Derivatives from para‐amino‐benzoic acid and phloroglucinol were about one half as active, while the dye from H acid was only amebastatic at dilutions between 1: 500 and 1: 5000.The relationship between chemical structure and biological activity of these bisazo dyes was discussed.
Decomposition reactions of 4‐nitropyridine
Authors: den Hertog H. J. , Broekman F. W. , Combé W. P. 
Published: September 2010

Abstract4‐Nitropyridine is converted into a mixture containing salts of N‐(4′‐pyridyl)‐4‐pyridone and 4‐pyridone, when kept at room temperature for some weeks.The mechanism of this decomposition reaction is discussed.
Derivatives of oxazolidinedione‐2,4: II. The reaction of α‐hydroxy‐esters with isocyanates
Authors: Rekker R. F. , Faber A. C. , Tom D. H. E. , Verleur H. , Nauta W. Th. 
Published: September 2010

AbstractThe reaction between an isocyanate and an α‐hydroxy‐ester leads to the formation of an N‐substituted carbamylo‐α‐hydroxy‐ester, which can give an oxazolidinedione‐2,4 under the influence of a small amount of metallic sodium by ring closure with the splitting off of alcohol.This ring closure can sometimes be brought about without the use of sodium, by heating the carbamylo‐α‐hydroxy‐ester to a sufficiently high temperature.Whether or not the required ring closure takes place on heating, depends apparently upon the nature of the carbon substituents of the carbamylo‐α‐hydroxy‐ester, since the latter, on heating to a higher temperature, sometimes can give an isocyanate.
Preparation of 2‐amino‐3‐nitronaphthalene
Authors: van Rij J. H. , Verkade P. E. , Wepster B. M. 
Published: September 2010

AbstractSo far 2‐amino‐3‐nitronaphthalene has not been obtained in a pure state. The preparation of this substance by the partial reduction of 2,3‐dinitronaphthalene with sodium disulphide is described.
Osmotic permeability of cupric ferrocyanide membranes
Authors: Mibashan A. 
Published: September 2010

AbstractI. The osmotic permeability of a cupric ferrocyanide membrane deposited on porous pyrex was determined at 22° and 33° C for glucose solutions up to 25%, with errors below 2%.It was found that the so‐called “seasoning” of the cell took place at 33° in two jumps at an osmotic pressure of 33 atm. After seasoning the cell is considerably more permeable to water and the velocity vs. concentration curve displays greater steepness and less curvature.II. Experiments were carried out with the system glucose solution ‐ semipermeable membrane ‐ aminopyrine solution, and an increase of concentration of 11.7% resp. 23.0% in the latter was obtained.
Migration of halogen atoms in halogenoderivatives of 2,4‐dihydroxypyridine (I)
Authors: den Hertog H. J. , Schogt J. C. M. 
Published: September 2010

AbstractWhen 3‐bromo‐2,4‐dihydroxypyridine is chlorinated in aqueous hydrochloric acid solution by adding hydrogen peroxide solution, 5‐bromo‐3‐chloro‐2,4‐dihydroxypyridine is formed. Hence the chlorine atom enters the 3‐position, the bromine atom being removed from this position and reintroduced at the 5‐position.5‐Bromo‐3‐chloro‐2,4‐dihydroxypyridine was also prepared by brominating 3‐chloro‐2,4‐dihydroxypyridine and chlorinating 5‐bromo‐2,4‐dihydroxypyridine. Its structure was established in different ways, i. e. by converting it into 3‐chloro‐2,4‐dihydroxypyridine on partial reduction, by converting it into 4‐amino‐2,3‐dichloro‐5‐bromopyridine and into 4‐amino‐2,5‐dibromo‐3‐chloropyridine. The structure of the two compounds last mentioned was proved by synthesis.
Compounds related to provitamin D3 (III)): Homocholesterol and the corresponding provitamin (3‐homoprovitamin D3)
Authors: Strating J. , Backer H. J. 
Published: September 2010

Abstract3‐Homocholesterol (III), obtained by action of LiAlH4 on cholesteryl‐3‐carboxylic methyl ester (II), which has been prepared from cholesteryl chloride by Grignard reaction, has the same steric configuration (β) at carbon atom 3 as cholesterol. Bromination of its acetate (IV) by means of bromosuccinimide, followed by elimination of HBr, leads to the acetate of 3‐homoprovitamin D3 (Vα).This 3‐homoprovitamin D3 (IX) can be synthesized with a far better yield by introducing first the double bond 7 and then the hydroxymethyl group 3. The magnesium derivative of 7‐dehydrocholesteryl chloride is transformed by CO2 into the carboxylic acid (VII), which is readily methylated with diazomethane. Finally the 7‐dehydrocholesteryl‐3‐carboxylic methyl ester (VIII) is reduced with LiAlH4 to 3‐homoprovitamin D3 (IX).It is pointed out that the ultraviolet absorption characteristic for the conjugated system of double bonds 5‐7 is subjected to an influence of molecular size.
The synthesis and pyrolysis of radio‐active ethyl formate (HC14OOC2H5)
Authors: van den Bos B. G. , Aten A. H. W. 
Published: September 2010

AbstractThe synthesis is described of radioactive ethyl formate, labeled with C14 in the formate group. The pyrolysis of this compound yields radioactive carbon dioxide and inactive ethylene. This indicates that the decomposition is brought about by a simple splitting of the molecule.
Reactivity of 4‐nitropyridine‐N‐oxide: Preparation of 4‐substituted derivatives of pyridine‐N‐oxide and pyridine
Authors: den Hertog H. J. , Combé W. P. 
Published: September 2010

AbstractIt is shown that the nitro‐group in 4‐nitropyridine‐N‐oxide can be readily replaced by negative ions and that the N‐oxides thus obtained, can be reduced quantitatively to the corresponding pyridine derivatives.This fact reveals an excellent method for the preparation of several 4‐substituted pyridine‐N‐oxides and pyridines. It is all the more useful, since the synthesis of 4‐nitropyridine‐N‐oxide has been simplified.The preparation of 4‐bromo‐, 4‐chloro‐ and 4‐ethoxypyridine‐N‐oxide is described in detail.
Trichloracétamidines substitués
Authors: Backer H. J. , Wanmaker W. L. 
Published: September 2010

AbstractEn faisant réagir des amines aliphatiques et aromatiques sur le trichloracétonitrile, les auteurs ont préparé plusieurs trichloracétamidines. L'addition de guanidines et d'amidines à ce nitrile conduit à des dérivés moins simples de la trichloracétamidine.Trois nouveaux composés, soumis à l'examen bactériologique, ont présenté une activité bactériostatique. Cependant leur activité est inférieure à celle du sulfanilamide et leur toxicité en exclue l'application.
Quelques acides ptéroylglutamiques (foliques) substitués dans le noyau benzénique
Authors: Backer H. J. , Houtman A. C. 
Published: September 2010

AbstractLe mémoire décrit la préparation et les propriétés de six dérivés de l'acide ptéroylglutamique (folique) avec un substituant dans le noyau de l'acide p‐aminobenzoïque. Un de ces acides peut remplacer l'acide ptéroylglutamique comme facteur de croissance pour “Streptococcus faecalis R.”. Parmi les autres dérivés il y a trois acides doués de propriétés bactériostatiques. L'un d'eux est un antagoniste compétiteur puissant.
Cis‐ and trans‐dichloroethene
Authors: Johnsen S. E. J. , Fitzpatrick J. W. 
Published: September 2010

AbstractBroers, Ketelaar and van Velden (Rec. trav. chim. 69, 1122 (1950)) have reported values for the melting points and heats of fusion of cis‐ and trans‐dichloroethene. They compare their best values with those reported by Timmermans (Bull. soc. chim. Belg. 27, 337 (1913)), and Chavanne (Ibid. 26, 287 (1912)).
Volumetric amino‐nitrogen determinations in glycine and glycyl‐peptides
Authors: Sluyterman L. A. Æ. , Kooistra M. 
Published: September 2010

AbstractBy addition of mercuric chloride to the reaction‐mixture in the Van Slyke apparatus, practically the theoretical values for the amino‐nitrogen content of glycine and peptides having a terminal glycyl‐rest are obtained. If a considerable amount of lithium bromide is present at the same time, the effect of mercuric chloride is greatly lost. Using potassium iodide in that case the right value is found for glycine, but the values for diglycine and triglycine are 7% and 5% too high.
Partially hydrogenated naphthoic acids and α‐alkyl‐phenylacetic acids: Researches on plant growth regulators XIX. Structure/activity IV
Authors: Veldstra H. , van de Westeringh C. 
Published: September 2010

Abstract(dl) 1,2,3,4‐Tetrahydro‐α‐naphthoic acid, selected for investigation on account of the fact that we deemed it to meet especially well the spatial requirements for active compounds, proved to be very active in the pea‐test, After resolution of the racemate (with (−)menthylamine) it appeared that its activity for the greater part is due to that of the (−)acid (activity comparable with that of α‐naphthylacetic acid), the (+)acid being weakly active only.(dl)8‐Methyl‐1,2,3,4‐tetrahydro‐α‐naphthoic acid shows the same activity as the unsubstituted acid. 1,2,3,4‐Tetrahydro‐β‐naphthoic acid and its 8‐methyl‐derivative are inactive. A possible explanation for this inactivity is discussed.As “open” forms of these partially hydrogenated naphthoic acids a number of (dl)α‐alkyl‐phenylacetic acids was investigated, of which (dl)allyl‐phenylacetic acid proved to be the most active one. The resolution of this acid was carried out by means of (+) and (−)α‐phenyl‐ethylamine. Here the (−)acid is practically inactive, the whole of the activity being due to the (+)acid).There are indications that the active (−) 1,2,3,4‐tetrahydro‐α‐naphthoic acid and (+) allyl‐phenylacetic acid belong to the same steric series.
Symbiosis of tryptophan‐deficient mutants of E. coli B
Authors: Winkler K. C. , van Doorn A. W. J. , Royers A. F. M. 
Published: September 2010

AbstractIn his laboratory Bungenberg de Jong taught us the properties of complex‐systems of all kinds of bio‐colloids. In all this teaching “nucleic acid‐complexes” was his best subject, because here he set us many examples using his own genes as illustrations. Expressed in his many good qualities as an ingenious scientist and as a genial and generous man, these genes were the best possible illustrative material a student can ever have.The way Bungenberg de Jong affected his collaborators raises the question whether genetic transformations are possible only in pneumococci, I at least carry with me something for life!From artificial complex coacervates, crossing the borderland between colloid chemistry and biology — Bungenberg de Jong's own kingdom — I turned to the natural complex systems we call bacteria. May the following humble and unimportant note express in some way my admiration and love for the master who guided my steps and polarized my brain.
Orientation in cellulose fibers as derived from measurements of dichroism of dyed fibers
Authors: Hermans P. H. , Heikens D. 
Published: September 2010

AbstractFrom accurate measurements of dichroism on dyed model filaments by photoelectric and visual methods a measure for the overall orientation of the dyestuff molecules in the fiber is derived and compared to the overall onentation of the fiber substance as derived from X‐ray and optical measurements. The results are discussed in connection with similar measurements on rayon fibers.
Différents Équilibres de Phases dans Les Solutions D'acétate de Cellulose
Authors: Dervichian D. G. , Magnant C. 
Published: September 2010

AbstractLe systèm diacétate de cellulose + chloroforme + alcool a été étudié, du point de vue de l'equilibre des phases, dans toute l'étendue des concentrations possibles de chacun des trois constituants. En plus d'un second domaine de coacervation, on a pu ainsi mettre en évidence des phases isotropes et anisotropes et établir le diagramme général du systéme. Ce diagramme de phases rappelle par certains cǒtés ceux des systèmes contenant des électrolytes colloidaux en solutions aqueuses.
Influence of electric charge and valence of ions on the specific precipitation of diphtheria toxin with antitoxic horse serum)
Authors: Dekker W. A. L. , v. d. Meer C. 
Published: September 2010

AbstractThe striking similarity of phenomena found in specific precipitation with those encountered in complex colloid flocculation (in the sense of Bungenberg de Jong et al.) affords reason to expect a similarity of reaction mechanism. By studying the influence of neutral salts on the flocculation of diphtheria toxin with antitoxic horse serum we have tried to answer the question whether electrostatic attraction is as essential for specific precipitation as it is for complex colloid flocculation.
Reaction products of primary β‐hydroxy‐amines with carbonyl compounds. III. Ultraviolet spectra
Authors: Bergmann Ernst D. , Hirshberg Y. , Pinchas S. , Zimkin E. 
Published: September 2010

AbstractFor a number of products of the condensation between ethanolamine or 2‐amino‐3‐methyl‐butanol‐3 and aromatic aldehydes and ketones. the ultraviolet spectrum has been measured. The observations have been used to distinguish between oxazolidine and Schiff's base structures of the condensation products.The agreement between the results and the conclusions derived from measurements of the molecular refraction and the infrared spectrum, is satisfactory.For a number of simple model substances, too, the ultraviolet spectra have been measured, in order to determine the characteristics of the CN‐spectrum.
Reaction products of primary β‐hydroxy‐amines with carbonyl compounds. V. The dipole moments of 1,3‐dihetero‐substituted 5‐membered ring systems and some related problems
Authors: Bergmann Ernst D. , Fischer Ernst , Zimkin E. , Pinchas S. 
Published: September 2010

AbstractThe dipole moments have been determined for eleven 1,3‐dioxolanes, four oxazolidines and two isomeric Schiff's bases, and four imidazolidines. The influence of the molecular structure of the substances on these moments has been discussed. Certain anomalies appear consistently in the physical constants of the heterocyclic compounds, when they are derived from cyclopentanone, methylisobutylketone or diisobutylketone. In order to obtain a better insight into these anomalies, seven more 1,3‐dioxolanes have been synthesized and their molecular refraction and infrared spectrum studied. Furthermore, the condensation of three ketones with ethanolamine and 3‐methyl‐2‐amino‐butanol‐3 has been investigated, and the molecular refraction and infrared absorption of the products determined and evaluated.