bluuebunny/crossref_metadata_2025_split huggingface dataset:
A long‐term study on the impact of climatic variables on two common nest‐dwelling ectoparasites of the Eurasian blue tit (Cyanistes caeruleus)
Authors: MERINO Maritxu , GARCÍA‐DEL RÍO Marina , CASTAÑO‐VÁZQUEZ Francisco , MERINO Santiago 
Published: May 2024

AbstractWe explored the potential influence of temperature and precipitation on the abundance of two nest‐dwelling ectoparasites (blowflies and mites) of Eurasian blue tits (Cyanistes caeruleus) during a period of 21 years and compared the results with those of a shorter period. The abundance of blowflies was negatively related to precipitation, which could prevent flies from locating their host, and laying date. In addition, blowflies were positively related to brood size (more food implies more parasites) and the interaction between precipitation and temperature. The highest abundances of blowfly pupae were attained in conditions of increasing precipitation and decreasing temperature, which should be more common at the beginning of the bird breeding season. Mites were significantly and positively related to laying date and the interaction between average precipitation and temperature but only for the larger dataset. Higher abundances of mites were related to intermediate values of temperature and precipitations, conditions that are found at the end of the breeding season. These results imply that optimal conditions for both parasites differ, with blowflies preferring earlier breeders and colder and more humid conditions than mites. Thus, the effects of the climatic conditions studied on parasite abundances are non‐monotonic and can vary with years and parasite species. Finally, the fact that average temperature and precipitation decreases across the years of study is probably due to the advancement in Eurasian blue tit laying date because we calculated those variables for the period of birds’ reproduction. This earlier nesting does not affect parasite abundance.
The rhizosphere of a drought‐tolerant plant species in Morocco: A refuge of high microbial diversity with no taxon preference
Authors: Legeay Jean , Errafii Khaoula , Ziami Abdelhadi , Hijri Mohamed 
Published: May 2024

AbstractArid and semi‐arid areas are facing increasingly severe water deficits that are being intensified by global climate changes. Microbes associated with plants native to arid regions provide valuable benefits to plants, especially in water‐stressed environments. In this study, we used 16S rDNA metabarcoding analysis to examine the bacterial communities in the bulk soil, rhizosphere and root endosphere of the plant Malva sylvestris L. in Morocco, along a gradient of precipitation. We found that the rhizosphere of M. sylvestris did not show significant differences in beta‐diversity compared to bulk soil, although, it did display an increased degree of alpha‐diversity. The endosphere was largely dominated by the genus Rhizobium and displayed remarkable variation between plants, which could not be attributed to any of the variables observed in this study. Overall, the effects of precipitation level were relatively weak, which may be related to the intense drought in Morocco at the time of sampling. The dominance of Rhizobium in a non‐leguminous plant is particularly noteworthy and may permit the utilization of this bacterial taxon to augment drought tolerance; additionally, the absence of any notable selection of the rhizosphere of M. sylvestris suggests that it is not significatively affecting its soil environment.
Bank sentiment and liquidity hoarding
Authors: Berger Allen N. , Kim Hugh Hoikwang , Ma Xiaonan “Flora” 
Published: May 2024

AbstractWe analyze how bank sentiment affects bank liquidity hoarding, distinguishing unexplained beliefs of bank managers from fundamental‐based beliefs. We build a bank management sentiment measure from textual analysis of 10‐Ks and utilize a comprehensive bank liquidity hoarding measure. We find that negative bank sentiment increases liquidity hoarding not warranted by a bank's fundamental conditions or external circumstances. Further analysis confirms that our findings reflect bank volition rather than being driven solely by borrowers or depositors. We address endogeneity concerns using exogenous weather conditions as instruments. Overall, our findings suggest that bank sentiment can influence how much liquidity banks provide to the economy and financial system.
Glycemic control assessed by continuous glucose monitoring during pregnancy in women with type 1 diabetes and its association with preeclampsia, an observational Swedish cohort study
Authors: Englund Ögge Linda , Dotevall Annika , Elfvin Anders , Sandgren Ulrika , Linden Karolina , Bohlin Linnea , Wallstersson Bernadette , Sjödell Mårten , Augustinsson Jaine , Hagman Anna 
Published: May 2024

AbstractIntroductionWomen with type 1 diabetes have an increased risk of preeclampsia (PE), but it is not fully understood if degree of glycemic control is associated with this risk. The aim of this study was to assess glycemic control during pregnancy analyzed by continuous glucose monitoring (CGM) in women with and without PE and to investigate if glycemic control is associated with increased risk of PE.Material and MethodsA total of 120 pregnant Swedish women with type 1 diabetes using CGM were included. Background factors and pregnancy outcomes were collected from medical records. CGM data were collected via the internet‐based platform Diasend. Mean glucose, standard deviation of mean glucose, percentage of time in target, time below target, and time above target were presented for each trimester in women who did or did not develop PE. Associations between CGM‐derived metrics and PE were analyzed with logistic regression and adjusted for confounders.ResultsTwenty‐two women (18.3%) developed PE. There were no significant differences in maternal characteristics between women with and without PE. Glycemic control improved in each trimester but was suboptimal in both groups. Time in target increased from 59% in the non‐PE group and 54% in the PE group in the first trimester to 65% in both groups in the third trimester. There were no significant associations between glycemic control and PE after adjustment for confounders.ConclusionsDegree of glycemic control during pregnancy assessed by CGM was not associated with development of PE in women with type 1 diabetes. However, more research is needed to understand the role of glycemic control in relation to development of PE.
Women with a history of gestational diabetes mellitus present an accumulation of cardiovascular risk factors at age 46—A birth cohort study
Authors: Bakiris Evi , Luiro Kaisu , Jokelainen Jari , Morin‐Papunen Laure , Keinänen‐Kiukaanniemi Sirkka , Kaikkonen Kari , Piltonen Terhi , Tapanainen Juha S. , Auvinen Juha 
Published: May 2024

AbstractIntroductionThe incidence of gestational diabetes mellitus (GDM) is globally increasing, and it has been associated with later type 2 diabetes, metabolic syndrome (MetS), and cardiovascular disease (CVD). However, long‐term population‐based studies investigating common CVD risk factors years after pregnancy are lacking. To evaluate the future mortality and morbidity in cardiovascular and metabolic diseases, we conducted a thorough investigation of midlife risk factors in women with and without previous GDM.Material and MethodsA prospective population‐based cohort study was conducted of 3173 parous women from the Northern Finland Birth Cohort, 1966. Study participants were obtained from the national register or patient records. Those with a GDM diagnosis formed the GDM cohort (n = 271), and those without a previous GDM diagnosis formed the control cohort (n = 2902). Clinical examinations were performed on participants at the age of 46 and included anthropometric measurements, oral glucose tolerance test (OGTT), biochemical measurements, and cardiovascular assessment.ResultsAt the age of 46, women in the GDM cohort had a higher body mass index (BMI, 29.0 kg/m2 vs 26.3 kg/m2, p < 0.001) and greater waist circumference (94.1 cm vs 86.5 cm, p < 0.001) than the control cohort. In the GDM cohort, a higher incidence of impaired glucose tolerance (12.6% vs 7.3%, p = 0.002), more previously diagnosed and OGTT‐detected type 2 diabetes (23.3% vs 3.9%, p < 0.001), lower high‐density lipoprotein (1.53 mmol/L vs 1.67 mmol/L, p = 0.011), higher triglycerides (1.26 mmol/L vs 1.05 mmol/L, p = 0.002) and a higher fatty liver index (6.82 vs 2.47, p < 0.001), were observed even after adjusting for BMI, polycystic ovary syndrome, parity, level of education, physical activity, smoking, and alcohol consumption. The women in the GDM cohort also had more MetS (42.6% vs 21.9%, p < 0.001) and higher risk scores for CVD and fatal events (Framingham 4.95 vs 3.60, p < 0.001; FINRISK 1.71 vs 1.08, p < 0.001).ConclusionsWomen with a previous diagnosis of GDM exhibit more risk factors for CVD in midlife and are at a higher risk for cardiovascular events later in life.
Current evidence of synaptic dysfunction after stroke: Cellular and molecular mechanisms
Authors: Li Chuan , Jiang Min , Fang Zhi‐Ting , Chen Zhiying , Li Li , Liu Ziying , Wang Junmin , Yin Xiaoping , Wang Jian , Wu Moxin 
Published: May 2024

AbstractBackgroundStroke is an acute cerebrovascular disease in which brain tissue is damaged due to sudden obstruction of blood flow to the brain or the rupture of blood vessels in the brain, which can prompt ischemic or hemorrhagic stroke. After stroke onset, ischemia, hypoxia, infiltration of blood components into the brain parenchyma, and lysed cell fragments, among other factors, invariably increase blood–brain barrier (BBB) permeability, the inflammatory response, and brain edema. These changes lead to neuronal cell death and synaptic dysfunction, the latter of which poses a significant challenge to stroke treatment.ResultsSynaptic dysfunction occurs in various ways after stroke and includes the following: damage to neuronal structures, accumulation of pathologic proteins in the cell body, decreased fluidity and release of synaptic vesicles, disruption of mitochondrial transport in synapses, activation of synaptic phagocytosis by microglia/macrophages and astrocytes, and a reduction in synapse formation.ConclusionsThis review summarizes the cellular and molecular mechanisms related to synapses and the protective effects of drugs or compounds and rehabilitation therapy on synapses in stroke according to recent research. Such an exploration will help to elucidate the relationship between stroke and synaptic damage and provide new insights into protecting synapses and restoring neurologic function.
The expression characteristic and prognostic role of Siglec‐15 in lung adenocarcinoma
Authors: Sun Haijun , Du Qilong , Xu Yuyu , Rao Cheng , Xu Li , Yang Junrong , Mao Yuan , Wang Lin 
Published: May 2024

AbstractSialic acid‐binding immunoglobulin‐like lectin‐15 (Siglec‐15) has been identified as an immune suppressor and a promising candidate for immunotherapy of cancer management. However, the association between Siglec‐15 expression and clinicopathological features of lung adenocarcinoma (LUAD), especially the prognostic role, is not fully elucidated. In this present study, a serial of bioinformatics analyses in both tissue and cell levels were conducted to provide an overview of Siglec‐15 expression. Real‐time quantitative PCR (qPCR) test, western blotting assay, and immunohistochemistry (IHC) analyses were conducted to evaluate the expression of Siglec‐15 in LUAD. Survival analysis and Kaplan–Meier curve were employed to describe the prognostic parameters of LUAD. The results of bioinformatics analyses demonstrated the up‐regulation of Siglec‐15 expression in LUAD. The data of qPCR, western blotting, and IHC analyses further proved that the expression of Siglec‐15 in LUAD tissues was significantly increased than that in noncancerous tissues. Moreover, the expression level of Siglec‐15 protein in LUAD was substantially associated with TNM stage. LUAD cases with up‐regulated Siglec‐15 expression, positive N status, and advance TNM stage suffered a critical unfavorable prognosis. In conclusion, Siglec‐15 could be identified as a novel prognostic biomarker in LUAD and targeting Siglec‐15 may provide a promising strategy for LUAD immunotherapy.
Structural and functional effects of global invasion pressure on benthic marine communities—patterns, challenges and priorities
Authors: Zaiko Anastasija , Cardeccia Alice , Carlton James T. , Clark Graeme F. , Creed Joel C. , Davidson Ian , Floerl Oliver , Galil Bella , Grosholz Edwin , Hopkins Grant A. , Johnston Emma L. , Kotta Jonne , Marchini Agnese , Ojaveer Henn , Ruiz Gregory , Therriault Thomas W. , Inglis Graeme J. 
Published: May 2024

AbstractAimRetrospective (pre‐ vs. post‐invasion) and cross‐sectional comparisons of ecosystems exposed to high and low bioinvasion pressure, provide an alternative approach to evaluate shifts in biological communities associated with non‐indigenous species (NIS) introductions. In this study, we aimed to examine general patterns of change in community composition, structure and function in six well‐studied and globally distributed marine ecosystems that had documented histories of biological invasions.LocationGlobal.MethodsBy considering a range of regional datasets and different sampling approaches, we evaluated trends within and among ecosystems by comparing paired measures of community and functional structure in either space or time.ResultsOur analyses revealed different patterns of structural and functional change at ecosystem scales, but direct comparisons across regions were hindered by confounding effects of study designs and other drivers of change. The most prominent shifts in community composition were observed in the retrospective studies, characterised by the greatest relative contribution of NIS. No uniform pattern of change in functional metrics was observed across study regions. However, functional evenness and dispersion showed a tendency to increase in systems under higher invasion pressure, refuting the hypothesis of selective accumulation of specific traits and functional homogenisation within ecosystems exposed to high invasion pressure.Main ConclusionsAccumulation of NIS within broader communities can be a subtle process, with inherent spatial and temporal variability. Nonetheless, not only do species' proportional contributions to communities change over time in areas subjected to high bioinvasion pressure, but trait profiles can incrementally shift, which alters the original ecology of an area. Planned, long‐term studies that incorporate a range of measures of environmental drivers and ecosystem response are crucial for better understanding of cumulative, community‐level and ecosystem‐scale change associated with biological invasions.
Validation of the Individualized Metabolic Surgery score in predicting long‐term remission of diabetes after duodenal switch‐type procedures
Authors: Almuallem Sultan , Ali Abdulaziz Karam , Vourtzoumis Phil , Demyttenaere Sebastian , Court Olivier , Andalib Amin 
Published: May 2024

AbstractAimTo validate the Individualized Metabolic Surgery (IMS) score and assess long‐term remission of type 2 diabetes (T2D) after duodenal switch (DS)‐type procedures in patients with obesity. In addition, to help guide metabolic procedure selection for those patients categorized as having severe T2D.Materials and MethodsThis is a retrospective single cohort study of all patients with T2D and severe obesity, who underwent DS‐type procedures at a single institution from December 2010 to December 2018. Study endpoints included validating the IMS score in our cohort and evaluating the impact of DS‐type procedures on long‐term (≥ 5 years) remission of T2D, especially in patients with severe disease. A receiver operator characteristic curve was used to assess the accuracy of the IMS score using the area under the curve (AUC).ResultsThe study cohort included 30 patients with complete baseline and long‐term glycaemic data after their index DS‐type surgery. Twelve patients (40%) were classified with severe T2D, and the distribution of IMS‐based severity groups was similar between our cohort and the original IMS study (P = .42). IMS scores predicted long‐term T2D remission with AUC = 0.77. Patients with IMS‐based severe diabetes achieved significantly higher long‐term remission after DS‐type procedures compared with gastric bypass and/or sleeve gastrectomy from the original IMS study (42% vs. 12%; P < .05).ConclusionsThe IMS score properly classifies the severity of T2D in our study cohort and adequately predicts its long‐term remission after DS‐type procedures. While T2D remission decreases with more severe IMS scores, long‐term remission remains high after DS‐type procedures among patients with severe disease.
Absence of female preference and the origin of a unisexual species, the Amazon molly (Poecilia formosa)
Authors: Smith Caden , Berbel‐Filho Waldir Miron , Spikes Montrai , Fyon Frederic , Úbeda Francisco , Schlupp Ingo 
Published: May 2024

AbstractThe role of hybridization as a formative process in evolution has received much attention in the past few decades. A particularly fascinating outcome of hybrid speciation is the formation of asexual hybrid species. The Amazon molly (Poecilia formosa) is such a hybrid and originated from a P. mexicana mother and a P. latipinna father. Consequently, a heterospecific mating must have occurred leading to the Amazon molly, indicating a breakdown of any potential prezygotic isolation between parental species. Here we studied the female mate preferences of extant P. mexicana and P. latipinna from several populations using standard binary choice tests with males of both sexual species that were matched for size. Poecilia mexicana and P. latipinna can be crossed in the lab, however, the offspring are not asexual, but sexual F1s. In our study, we generated F1s and tested their mating preferences with sexual males of both P. mexicana and P. latipinna against F1 males. Overall, our results show that in extant P. mexicana and P. latipinna no female preference for conspecific males was detectable. Consequently, heterospecific matings are possible and not hindered by any apparent behavioral prezygotic isolation. If female preferences in these species were comparable around the time the Amazon molly originated as a hybrid species ca. 100,000 years ago, matings leading to hybrids would be very likely. F1 females also have no discernable mating preferences for either sexual males or F1 males. Such lack of prezygotic behavioral isolation could potentially lead to F2 individuals, backcrosses, and introgression.
Realist synthesis of a rapid response system in managing mental state deterioration in acute hospital settings
Authors: Dziruni Tendayi Bruce , Hutchinson Alison M. , Coomer Jack , Keppich‐Arnold Sandra , Bucknall Tracey 
Published: May 2024

AbstractMental state deterioration in patients poses significant challenges in healthcare, potentially resulting in adverse outcomes for patients and continued reliance on restrictive interventions. Implementing evidence‐based approaches such as a rapid response system that prioritises early identification and intervention can effectively manage adverse outcomes. However, little is known regarding the effectiveness of these interventions. The objective of this synthesis was to test and refine initial programme theories by synthesising evidence to understand what works, for whom and under what circumstances. Based on the realist synthesis methodology, we searched EMBASE, CINAHL, MEDLINE, the Cochrane Library and grey literature for evidence to inform contexts, mechanisms and outcomes on the functioning of a rapid response model. We identified 28 relevant sources encompassing peer‐reviewed journal articles and grey literature. This synthesis identified three important elements that contribute to the effectiveness of a rapid response system for managing mental state deterioration: care processes, therapeutic practices and organisational support. Essential elements include improving confidence and clinical skills through training, timely assessment and intervention, teamwork, communication and the creation of governance structures for monitoring and evaluation. To ensure the effectiveness, an organisation must adopt a comprehensive approach that incorporates organisational support, resource allocation, training, clear communication channels and commitment to continuous quality improvement. However, implementing interventions within a complex healthcare system requires thoughtful consideration of the organisational culture and governance structures. By taking a comprehensive and holistic approach to improvement initiatives, organisations can strive to achieve optimal outcomes in managing mental state deterioration and improving patient care.
Cross‐Reactive Antibody Responses to Coronaviruses Elicited by SARS‐CoV‐2 Infection or Vaccination
Authors: Lee Richard S. H. , Cheng Samuel M. S. , Zhao Jin , Tsoi Annie Y. S. , Lau Kaman K. M. , Chan CoCo H. C. , Li John K. C. , Hui David S. C. , Peiris Malik , Yen Hui‐Ling 
Published: May 2024

ABSTRACTBackgroundThe newly emerged SARS‐CoV‐2 possesses shared antigenic epitopes with other human coronaviruses. We investigated if COVID‐19 vaccination or SARS‐CoV‐2 infection may boost cross‐reactive antibodies to other human coronaviruses.MethodsPrevaccination and postvaccination sera from SARS‐CoV‐2 naïve healthy subjects who received three doses of the mRNA vaccine (BioNTech, BNT) or the inactivated vaccine (CoronaVac, CV) were used to monitor the level of cross‐reactive antibodies raised against other human coronaviruses by enzyme‐linked immunosorbent assay. In comparison, convalescent sera from COVID‐19 patients with or without prior vaccination history were also tested. Pseudoparticle neutralization assay was performed to detect neutralization antibody against MERS‐CoV.ResultsAmong SARS‐CoV‐2 infection−naïve subjects, BNT or CV significantly increased the anti‐S2 antibodies against Betacoronaviruses (OC43 and MERS‐CoV) but not Alphacoronaviruses (229E). The prevaccination antibody response to the common cold human coronaviruses did not negatively impact the postvaccination antibody response to SARS‐CoV‐2. Cross‐reactive antibodies that binds to the S2 protein of MERS‐CoV were similarly detected from the convalescent sera of COVID‐19 patients with or without vaccination history. However, these anti‐S2 antibodies do not possess neutralizing activity in MERS‐CoV pseudoparticle neutralization tests.ConclusionsOur results suggest that SARS‐CoV‐2 infection or vaccination may potentially modulate population immune landscape against previously exposed or novel human coronaviruses. The findings have implications for future sero‐epidemiological studies on MERS‐CoV.
Isolation of Naegleria lustrarea n. sp. (Excavata, Discoba, Heterolobosea) from the feces of Ambystoma annulatum (Ringed Salamander) in Northwest Arkansas
Authors: Becker Brian M. , Banson Idan , Walker James M. , Deshwal Anant , Brown Matthew W. , Silberman Jeffery D. 
Published: May 2024

AbstractThe salamander, Ambystoma annulatum, is considered a “species of special concern” in the state of Arkansas, USA, due to its limited geographic range, specialized habitat requirements and low population size. Although metazoan parasites have been documented in this salamander species, neither its native protists nor microbiome have yet been evaluated. This is likely due to the elusive nature and under‐sampling of the animal. Here, we initiate the cataloguing of microbial associates with the identification of a new heterlobosean species, Naegleria lustrarea n. sp. (Excavata, Discoba, Heterolobosea), isolated from feces of an adult A. annulatum.