bluuebunny/crossref_metadata_2025_split huggingface dataset:
Early predictive factors in routine clinical practice for rituximab therapy response in patients with rheumatoid arthritis
Authors: Mihajloska Evgenija , Dimkovski Aleksandar , Grozdanova Aleksandra , Vasilevska Ana , Antova Dubravka , Naumovska Zorica , Kapedanovska Nestorovska Aleksandra , Sterjev Zoran , Osmani Bashkim , Shuturkova Ljubica 
Published: June 2024

IntroductionIdentifying early predictive factors of how rheumatoid arthritis (RA) patients respond to rituximab (RTX) treatment is crucial for both individual treatment outcome and the improvement of clinical practice overall. This study aimed to identify early predictive factors available in standard clinical practice for predicting RTX treatment outcomes in RA patients.Material and methodsData on seventy patients diagnosed with RA treated with RTX (two 1,000 mg doses 2 weeks apart or two 500 mg doses 2 weeks apart) were retrospectively collected. Baseline information collected at the initiation of RTX treatment included patient characteristics such as age, sex, disease duration, disease activity, Health Assessment Questionnaire score, erythrocyte sedimentation rate, C-reactive protein, and serological status regarding rheumatoid factor and anti-cyclic citrullinated peptide antibodies. Clinical responses were analyzed 6 months after RTX initiation using the European Alliance of Associations for Rheumatology criteria. Potential predictors associated with positive RTX response at 6 months were identified using a multivariate ordinal logistic regression model.ResultsThe analysis showed that persistently active RA disease, Disease Activity Score in 28 Joints (DAS28) values at the treatment onset and after 3 months, along with erythrocyte sedimentation rate at treatment initiation, were negatively correlated with the response to RTX therapy (p < 0.05). All these correlations were statistically significant at the 99% confidence interval. The correlation and logistic regression analyses indicate that there are no significant association between rheumatoid factor and anti-cyclic citrullinated peptide antibodies concerning therapy response, despite a higher number of rituximab responders in the seropositive groups. Additionally, the study emphasizes the prognostic significance of the DAS28 value at treatment initiation in predicting therapy response at 6 months.ConclusionsThe optimal model for predicting RTX response at 6 months involves the interaction of all clinical factors examined in this study, as revealed by the analysis of multiple variables.
Analisis Produktivitas Usaha Kelap Sawit Pada PT. P. Bahrun & Sons di Kecamatan Juli Kabupaten Bireuen
Authors: Rizqi Safira , Nur T M 
Published: June 2024

ABSTRAK. Tujuan penelitian ini adalah untuk mengetahui Analisis Produktivitas Usaha Kelapa Sawit pada PT. P. BAHRUN & SONS di Kecamatan Juli Kabupaten Bireuen.Dalam mengelola data, penulis menggunakan metode kuantitatif dengan melihat aspek-aspek objek penelitian. Berdasarkan hasil penelitian diperoleh bahwa Biaya yang dikeluarkan oleh PT.P.BAHRUN & SONS di Kecamatan Juli Kabupaten Bireuen adalah sebanyak Rp.1.641.002.260/ tahun dan memperoleh pendapatan sebesar Rp.4.490.346.000, sehingga keuntungan yang diperoleh sebesar Rp. 2.849.343.740/tahun. Perhitungan produktivitas menunjukkan bahwa dalam setiap 1 ha lahan kebun kelapa sawit mampu menghasilkan 20,7089 ton kelapa sawit, dan dalam setiap Rp.1 biaya produksi yang dikeluarkan, PT.P.BAHRUN & SONS di Kecamatan Juli Kabupaten Bireuen mampu memperoleh keuntungan sebesar Rp.1,74.
Kata Kunci : Analisis, Produktivitas, Kelapa Sawit

ABSTRACT. The aim of this research is to determine the Analysis of Oil Palm Business Productivity at PT. P. BAHRUN & SONS in Juli Subdistrict, Bireuen Regency. In managing the data, the author utilized a quantitative method by examining various aspects of the research object. Based on the research findings, the cost incurred by PT. P. BAHRUN & SONS in Juli Subdistrict, Bireuen Regency is Rp.1,641,002,260 per year, with revenue amounting to Rp. 4,490,346,000, resulting in a profit of Rp. 2,849,343,740 per year. Productivity calculations indicate that each hectare of oil palm plantation is capable of producing 20.7089 tons of oil palm, and for every Rp.1 of production cost incurred, PT. P. BAHRUN & SONS in Juli Subdistrict, Bireuen Regency is able to generate a profit of Rp.1.74.
Keywords: Analysis, Productivity, Oil Palm
Safeguarding supply chains from cyber-physical system attacks frameworks and strategies
Authors: Motunrayo Oluremi Ibiyemi  , David Olanrewaju Olutimehin  
Published: June 2024

This review paper delves into the escalating challenge of safeguarding supply chains against cyber-physical system (CPS) attacks, emphasizing the critical role of CPS in modern supply chains and the multifaceted vulnerabilities they introduce. We systematically outline a comprehensive framework encompassing preventive measures, detection and response strategies, and recovery and resilience planning to mitigate these risks. Furthermore, we explore the implementation challenges inherent in integrating cybersecurity and physical security strategies, highlighting innovative technological solutions and the crucial role of policy and regulatory compliance. This paper aims to offer actionable insights for enhancing the security posture of supply chains, underscoring the importance of collaborative efforts among stakeholders to navigate the complex landscape of cyber-physical threats.
Keywords: Cyber-Physical Systems, Supply Chain Security, Cybersecurity, Physical Security, Recovery and Resilience, Policy and Regulation.
Cybersecurity in supply chains: Addressing emerging threats with strategic measures
Authors: Motunrayo Oluremi Ibiyemi  , David Olanrewaju Olutimehin  
Published: June 2024

This review paper explores the evolving landscape of cybersecurity threats within supply chains, highlighting strategic measures necessary to mitigate these risks. As supply chains integrate more deeply with digital technologies and global networks, they become more vulnerable to sophisticated cyber attacks that can severely disrupt operational integrity and security. This paper synthesizes existing literature to outline the major cybersecurity challenges faced by supply chains, examining case studies and best practices from various industries. Our findings underscore the prevalent threats such as ransomware, phishing, and insider attacks, which exploit the complex interdependencies and digital interfaces in supply chains. The review identifies effective strategic responses, including the integration of comprehensive cybersecurity frameworks, enhanced inter-organizational cooperation, and the implementation of real-time threat detection systems. Conclusively, the paper advocates for a holistic and proactive approach to cybersecurity, emphasizing continuous improvement and adaptive strategies to protect against the dynamic nature of cyber threats in supply chain contexts.
Keywords: Cybersecurity, Supply Chain Management, Risk Assessment, Continuous Monitoring, Incident Response, Blockchain Technology, Artificial Intelligence (AI), Collaboration and Information Sharing, Cyber Threats, Emerging Technologies.
Exploring Tuberculosis: A Theoretical Framework for Infection Regulation and Eradication
Authors: Naresh Kumar Jothi  
Published: June 2024

In this paper we explored the study of tuberculosis, throughout human history, tuberculosis (TB) has been a persistent challenge due to its severe consequences for society. It is an infectious disease transmitted by Mycobacterium tuberculosis (MT),more than 150 million years ago, it was thought to have originated from the genus Mycobacterium. Our theoretical framework presents methods for regulating and eradicating tuberculosis infections. This has led to the compartmentalization of the model population and the analytical solution of the ensuing model equations. To validate the outcomes of the theoretical approach, a numerical simulation has been deployed. This model carried out six compartment stage, susceptible, latent for a short time period and latent for long time period, infected in hospital, random infected at public place and the recovered class. In this model we examined Disease free equilibrium points (DFEP), Basic reproduction number R_0. Positive boundaries solution is used to describe the infection at particular stage. If R_0<1, the DFE is locally asymptotically stable, using Jacobian matrix we explored the negative Eigen values. Lyapunov function is used to examined the global stability of endemic equilibrium. We used Carrying out a simulation using random data in a selected region,using random values in MATLAB, to simulate the result of the model.
Limnophyes knispelae sp. n. and L. sartorii sp. n., two new crenophilous species from the Swiss Alps (Chironomidae, Orthocladiinae)
Authors: Moubayed Joel , Lods-Crozet Brigitte 
Published: June 2024

Limnophyes knispelae sp. n and L. sartorii sp. n. are diagnosed and described based on material collected in the high Alpine valley of the Rhône river and the cirque of Macun in the Swiss National Park (alt. 1800-2616 m a.s.l.). The first new species is described only as male adult, while the second as male adult and pupal exuviae. Main distinguishing characters found in the male adult of L. knispelae sp. n. L. sartorii sp. n. are: clypeus shield-like shaped; humeral pit typically circular with 3-4 or 9 lanceolate setae; virga strong spine-like; preepisternals vary from 4-6 to 4-8. The pupal exuviae of L. sartorii sp. n. is characterized by having frontal apotome domed; thoracic horn reduced to nose-like tubercle; posterior area of tergites II-VI with 1-7 rows of minute hooks; segment VIII with 5 lateral setae; inner posterior margin of anal lobe straight.
A combination of the latter relevant morphological characters has allowed us to consider each of the two new species as a local biogeographic representative of the Swiss Alps. Currently, the genus Limnophyes Eaton, 1875 is represented in Switzerland by 15 species. Consequently, the description of L. knispelae sp. n and L. sartorii sp. n. increases the total number in the genus to 17 known valid species from this country. Discussions and a differential diagnosis on the two new species are given, in which some morphological affinities and distinguishing characters with other related congeners are detailed and highlighted. Comments on the ecology and geographical distribution of the new species are also provided.
KEBIJAKAN FISKAL DI INDONESIA DALAM PERSPEKTIF ISLAM
Authors: Juwita Sari Della Tri , Apriani Rosi , Mariska Soneta , Hidayat Faisal 
Published: June 2024

The role of the state in Islam to maintain economic stability, ensuring the elwfare of its people. To achieve welfare, the government needs policy, namely fiscal policy. Expenditure budgets in Islam aims to achieve a society whose wealth is in accordance with material and spiritual values. The method used is literature study method where this method collect and searches for various information that can be obtained relevantly through books, articles, journals, and electronic sources such as eBook, website and others that support the search for information about fiscal policy in Indonesia the results of study are fiscal policy in Indonesia the perspective of Islamic economics. Fiscal policy consists of revenue and expenditure. In general, fiscal policy sourced from taxes in contrast to Islam the term tax is als called Dharibah. Fiscal policy based on Islam provides maslahah for community but the implementation of the policy will be hampered because Indonesia is based on the Law and Pancasila.
Um possível caminho para a aprendizagem crítica e colaborativa com alunos do quinto ano de uma escola publica estadual
Authors: Magalhães Benedita Neire Almeida de , Darsie Marta Maria Pontin 
Published: June 2024

Este artigo é resultado de uma parte da dissertação de mestrado defendida em 2023, e desenvolvida junto ao Programa de Pós-Graduação de Mestrado em Educação (PPGE), do Instituto de Educação da Universidade Federal de Mato Grosso (UFMT), na Linha de pesquisa: Educação Ciências e Educação Matemática. A mesma teve como objetivo de investigar a Contribuição da matemática critica baseado em resolução de problema colaborativa para a aprendizagem com alunos do 5º ano do ensino fundamental de uma escola pública da rede estadual de ensino no município de Jaciara_MT. A pesquisa caracteriza-se como de abordagem qualitativa e segue a perspectiva histórico-cultural como orientadora para a investigação. A produção dos dados se deu em 20 aulas, videografadas, envolvendo professor e alunos, tendo como metodologia de ensino a sequência didática, conforme os temas: “A vacinação de criança contra a Covid -19”, “As Queimadas no Pantanal” e o “Uso do Plástico doméstico”. Para este artigo trazemos dados e análise da temática “ A vacinação de crianças contra a Covid-19. A busca de informações pelos alunos sobre os temas propostos se deu na internet. Iniciamos encontros com uma roda de conversa e com a apresentação dos respectivos temas onde os alunos fizeram suas colocações, indagações a respeito dos mesmos. Em seguida a aplicação da Resolução Colaborativa de Problemas Matemáticos, que foram resolvidos nos grupos, ou seja, colaborativamente. A partir da análise interpretativa dos diálogos entre os estudantes participantes da ação didática e dos dados produzidos a partir de uma sequência didática é possivel apontar os seguintes resultados: o estímulo ao pensamento crítico que contribui para o debate e discussão em grupo; alunos mais ativos e colaborativos com os seus pares; desenvolvimento de habilidades da comunicação oral; melhora na aprendizagem dos alunos em relação ao conhecimento matemático; e a participação destes nos desafios de aprendizagem nas atividades propostas em sala de aula.
Biologia reprodutiva de Couepia ovalifolia (Schott.) Bentham (Chrysobalanaceae) na Restinga de Maricá, Rio de Janeiro, RJ
Authors: Gomes-Pimentel Rejane , Pinheiro Maria Celia Bezerra 
Published: June 2024

Couepia ovalifolia (Schott.) Bentham (Chrysobalanaceae) é um arbusto encontrado frequentemente nas restingas dos Estados de Alagoas, Pernambuco, Bahia, Espírito Santo e Rio de Janeiro. Este estudo abrange a biologia floral, o sistema de polinização, reprodução e os eventos fenológicos. A espécie possui flores brancas, perfeitas, nectaríferas, odoríferas e do tipo floral escova. As flores são protogínicas, com estigma receptivo (úmido e papiloso) na fase feminina. A abertura floral ocorre de forma lenta em diferentes horários do dia, sendo possível observar em uma mesma inflorescência botões e flores em diferentes estádios. Os grãos de pólen são pequenos, com 86% de viabilidade, sendo liberados de forma gradativa. A floração de C. ovalifolia é anual, abundante, contínua e assincrônica a nível populacional, com pico no mês de maio (estação fria e seca), período no qual 75% das plantas em florescendo na restinga. O tempo de floração de cada planta é de cerca de 20 dias. O fruto é do tipo drupa, de cor verde, com cerca de 4,7 cm. O desenvolvimento dos frutos ocorre em cerca de 172 dias (26 semanas), com pico de frutos maduros nos meses de outubro e novembro. A dispersão dos frutos é autocórica e foram registradas plântulas e plantas jovens no ambiente natural. As flores de C. ovalifolia são visitadas por 53 espécies de insetos de diferentes ordens. Os polinizadores efetivos e ocasionais são representados por abelhas, mariposas e borboletas. A espécie é auto-incompatível, produzindo frutos por xenogamia. A relação fruto/flor é baixa nas polinizações naturais (4,1%) e nas de xenogamia (10,6%).
Pengaruh Metode Pengolahan Terhadap Kadar Air, Kadar Abu, dan Kandungan
Authors: Elvira Ilian , Baihaqi Baihaqi , Faradilla RH Fitri , Rejeki Sri , Suci Ida Ayu 
Published: June 2024

Tanaman kelor (Moringa oleifera) merupakan spesies tanaman tropis yang tumbuh hampir diseluruh wilayah Sulawesi Tenggara. Tujuan penelitian ini yaitu untuk mengetahui pengaruh metode pengolahan terhadap nilai kadar air, kadar bau dan vitamin C daun kelor. Penelitian ini menggunakan metode pengamatan langsung pada penerapan beberapa teknologi pengolahan yang berbeda terhadap kualitas daun kelor. Hasil penelitian menunjukkan kadar air pada daun kelor segar yaitu 74,2 %. Kadar air mengalami penurunan signifikan pada daun kelor yang mengalami proses perlakuan pengeringan dan perlakuan blanshing+pengeringan yaitu 6,71% dan 13,23% namun dilain sisi proses perebusan menyebabkan peningkatan kadar air menjadi 83,46%. Selain itu, proses perlakuan pengeringan dan perlakuan blanshing+pengeringan juga menyebabkan menurunnya kadar vitamin C pada daun kelor yaitu 8,29% dan 29,25% berturut-turut. Secara keseluruhan semua perlakuan mampu meningkatkan kadar abu daun kelor yang dihasilkan.
IL PROGETTO “IL PAESAGGIO LINGUISTICO TORINESE”
Authors: Fiorentini Ilaria , Forlano Marco 
Published: June 2024

Il contributo intende fornire una descrizione del progetto “Il paesaggio linguistico torinese”, consistito in un’attività didattica di ricerca sul campo con studenti e studentesse universitarie che ha previsto la mappatura di quattro quartieri (San Salvario, Centro, Porta Palazzo, Quadrilatero) della città di Torino. Dopo una panoramica sugli studi sul paesaggio linguistico italiano e sulle loro possibili applicazioni in chiave educativa, verranno illustrati gli scopi, i metodi e i principali risultati del progetto, sia dal punto di vista didattico, sia rispetto ai dati raccolti e alle lingue documentate.

The project “The Linguistic Landscape of Turin”

The aim of this paper is to describe the project “The Linguistic Landscape of Turin”, which consisted of a fieldwork activity with university students that involved the mapping of four districts (San Salvario, Centro, Porta Palazzo, Quadrilatero) of the city of Turin. After an overview of studies on the Italian linguistic landscape and their possible pedagogical applications, the aims, methods and main results of the project are presented, both from an educational point of view and in terms of the data we collected and the languages we documented.
LO SVILUPPO DEL LINGUAGGIO FUNZIONALE IN UN ALUNNO CON ASD MEDIATO DALLA GAMIFICATION: UN CASO DI STUDIO
Authors: Tundo Carolina 
Published: June 2024

Tutt’altro che infrequenti risultano le difficoltà linguistiche, manifestate dai soggetti con un Disturbo dello Spettro Autistico, nel campo della comunicazione e della produzione di richieste funzionali. Tali difficoltà influenzano anche la sfera relazionale, determinando una marcata compromissione della dimensione sociale. Viene qui presentato un caso di studio incentrato su un’attività didattica ludificata digitale, interamente progettata per la fruizione da parte di un alunno con ASD frequentante una scuola secondaria di primo grado. L’obiettivo principale del gioco consiste nell’implementare l’emissione di richieste funzionali all’interno di uno specifico contesto (il supermercato), così da consentire all’alunno di fare la spesa in autonomia. Il gioco, infatti, basato su una sequenza di esercizi didattici di difficoltà crescente realizzati mediante piattaforme educazionali come Scratch, WordWall, e LearningApps, è stato costruito pensando a un curriculummultidisciplinare, capace di coniugare e integrare abilità di tipo linguistico e matematico (operare semplici calcoli o maneggiare il denaro per pagare il conto alla cassa del supermercato). L’attività didattica ludificata assistita dalle ICT ha consentito all’alunno autistico la realizzazione di quello che David Ausubel (1968) avrebbe definito un «apprendimento significativo», utile a un pieno sviluppo non soltanto di abilità linguistiche e comunicative, ma anche della dimensione dell’autonomia.

Functional language development in a pupil with ASD mediated by gamification: a case study

Individuals with ASD frequently manifest language difficulties in the area of communication and production of functional demands. Such difficulties also affect their relational sphere, leading to a marked impairment of the social dimension. A case study is presented here, focusing on a digitally ludified educational activity, which was entirely designed for use by a student with ASD attending a secondary school. The main objective of the game is to implement the output of functional demands within a specific context (the supermarket), so as to enable the student to shop independently. The game is based on a sequence of language education exercises with increasing difficulty; individual exercises were implemented using educational platforms such as Scratch, WordWall, and LearningApps. The entire game was designed on the basis of a multidisciplinary curriculum, capable of developing first and foremost language skills, but also mathematical ones (operating simple calculations or handling money to pay the bill at the supermarket checkout). ICT-assisted ludified teaching activities enabled the student with ASD to achieve what David Ausubel (1968) would have called «meaningful learning», useful for a more accomplished development of language skills, but also for the expansion of the dimension of autonomy.
Morphology Basis of Cervical Cancer
Authors: Memic Muhamed , Asotic Amir 
Published: June 2024

Background: Cervical cancer is a cancer that occurs in the cells of the cervix–the lower part of the uterus that connects it to the vagina and represents a global public health problem. For many years, we have known that the main cause of preinvasive lesions and cervical cancer is the human papilloma virus (HPV). HPV infection is most common in young, sexually active women under the age of 25, but cervical cancer is more common in older women. In developing countries, this prevalence is higher and describe most frequent clinical manifestations in the praxis. Objective: The aim of this study was to analyze and describe morphology basis of cervical cancer. Methods: This is cross-sectional study based on meta-analysis of the facts published in scientific literature stored in indexed databases about morphology basis of the cervical cancer with description of clinical manifestations and its consequences describing morbidity and mortality rate in the population worldwide. Results and Discussion: The development of cervical cancer is associated with persistent infection with oncogenic types of HPV. The most common oncogenic types of HPV worldwide are HPV 16 and HPV 18 and are responsible for the development of more than 70% of all cervical cancers. HPV 16 has the greatest oncogenic potential. Due to oncogenic potential, human papilloma viruses are divided into high-risk, low-risk and undefined malignant potential. Low-risk types cause genital warts, while high-risk types are associated with preinvasive cervical lesions and cervical cancer. HPV infects basal cells of the squamous epithelium of the genital tract. Infection occurs at the site of microtrauma, areas of metaplasia, and through certain, little-known cellular receptors. Of the total infected, 1% develop a persistent infection, and in a small number of cases, one of the premalignant or malignant changes develops. For the occurrence of malignant changes, it is necessary that the infected organism has a decline in the body’s defenses, the existence or occurrence of other diseases and other viral infections, all with the cooperation of general risk factors (smoking, UV radiation, chemical agents) and with some risk behavior (promiscuity). Cervical intraepithelial (CIN) lesion is a premalignant change of the cervix that occurs due to chronic infection with high-risk types of HPV. Conclusion: It is very important in the future to connect the area of cervical cancer, HPV and DNA methylation, in order to better determine the changes that precede cervical cancer. Prevention and screening measures could also greatly reduce the incidence of HPV infection and the mortality rate caused by cervical cancer.