bluuebunny/crossref_metadata_2025_split huggingface dataset:
Post‐marketing surveillance of quetiapine fumarate extended‐release tablets in patients with bipolar depression
Authors: Kishi Taro , Iwata Nakao , Irie Hiroyuki , Aikawa Masaru 
Published: April 2024

AbstractAimThis study aimed to verify the real‐world efficacy and safety of quetiapine fumarate extended‐release tablets (Bipresso® 50 mg and 150 mg; marketing authorization holder is KYOWA Pharmaceutical Industry Co., Ltd., Osaka, Japan) in patients with bipolar depression.MethodsWe performed a post‐marketing surveillance with an observation period of 12 weeks.ResultsIn the safety analysis group (n = 345), adverse drug reactions (ADRs) occurred in 111 patients (32.17%). The most common ADRs (>1%) were somnolence in 55 patients (15.94%), akathisia in 11 (3.19%), dizziness in 10 (2.90%), weight increase in 6 (1.74%), thirst in 5 (1.45%), and hypersomnia, constipation, and nausea in 4 patients each (1.16%). The only severe ADR was one patient of suicidal ideation, and “longer time since the onset of the first episode” (p = 0.011) and “presence of complications” (p < 0.001) were identified as significant risk factors for the occurrence of ADRs. In the efficacy analysis group (n = 265), the average changes from baseline in the total Montgomery–Åsberg Depression Rating Scale (MADRS) score were −7.3 ± 8.8, −12.2 ± 10.7, −16.8 ± 12.7, and −13.2 ± 12.7 points after 4, 8, and 12 weeks, and at the last evaluation, respectively. The mean MADRS total score decrease had no significant association with maximum daily dose, diagnosis, and presence or absence of prior or concomitant treatment for bipolar disorder with mood stabilizers/antipsychotics/antidepressants.ConclusionThe efficacy of quetiapine fumarate extended‐release tablets was confirmed in clinical practice, and no new safety concerns or risks were identified.
Sound Exposure Promotes Intratympanic Drug Delivery to the Inner Ear
Authors: Ungar Omer J. , Situ Yumai , Spiegel Jennifer L. , Chen Joseph M. , Lin Vincent Y.W. , Le Trung N. 
Published: April 2024

AbstractObjectiveTo investigate the impact of sound exposure, with the resultant windows vibration on perilymphatic concentrations following intratympanic (IT) dexamethasone and gentamicin in an animal model.Study DesignAnimal model blinded study.SettingAnimal facility of a tertiary medical center.MethodsBilateral IT dexamethasone or gentamicin was applied to 15 tested rats. Following injections, each rat was exposed for 3 minutes to free field 30 dB sound pressure level (SPL), 512 vHz noise, with 1 external auditory canal plugged (contralateral control). Following noise exposure, perilymph was obtained from both ears. Drug concentrations were measured using ultrahigh‐performance liquid chromatography‐mass spectrometer.ResultsFor dexamethasone, the average (±SD) perilymphatic steroidal concentration was 0.417 µg/mL (±0.549) in the control ears versus 0.487 µg/mL (±0.636) in the sound‐exposed ears (P = .008). The average (±SD) gentamicin perilymphatic concentration was 8.628 µg/mL (±2.549) in the sound‐exposed ears, compared to 4.930 µg/mL (±0.668) in the contralateral control (nonsound exposed) ears. Sound exposure promoted steroidal and gentamicin diffusion to the inner ear by an averaged (±SD) factor of 1.431 and 1.730 (±0.291 and 0.339), respectively.ConclusionLow‐intensity noise (30 dB SPL) was found to enhance dexamethasone phosphate and gentamicin diffusion to the inner ear (by an averaged factor of ∼1.4 and 1.7, respectively) in a murine model.
Injection Laryngoplasty for Children with Dysphagia after Cardiac Surgery
Authors: Sheen Derek , Houser Thomas K. , Olsson Sofia E. , Dabbous Helene , Kou Yann‐Fuu , Johnson Romaine F. , Chorney Stephen R. 
Published: April 2024

AbstractObjectiveTo determine whether injection laryngoplasty (IL) resolves thin liquid aspiration among children with unilateral vocal cord paralysis (UVCP) after cardiac surgery.Study DesignRetrospective case‐control.SettingTertiary children's hospital.MethodsConsecutive children (<5 years) between 2012 and 2022 with UVCP after cardiac surgery were included. Resolution of thin liquid aspiration after IL versus observation was determined for children obtaining videofluoroscopic swallow studies (VFSS).ResultsA total of 32 children with left UVCP after cardiac surgery met inclusion. Initial surgeries were N = 9 (28%) patent ductus arteriosus ligations, N = 7 (22%) aortic arch surgeries, N = 9 (28%) surgeries for hypoplastic left heart syndrome, and N = 7 (22%) other cardiac surgeries. The mean age at initial surgery was 1.8 months (SD: 3.7). All children had a VFSS obtained after surgery that confirmed aspiration. There were 17 children that obtained an IL at 33.6 months (SD: 20.9) after cardiac surgery and 15 children observed without IL procedure. No surgical complications after IL were noted. The rate of aspiration resolution based on postoperative VFSS was N = 14 (82%) for the IL group and N = 9 (60%) for the control group P = .24. Documented VFSS aspiration resolution after cardiac surgery occurred by 9.6 months (SD: 10.0) in the observation group and 47.4 months (SD: 24.1) in the IL group (P < .001).ConclusionIL can help treat aspiration in children with UVCP after cardiac surgery but the benefit beyond observation remains unclear. Future studies should continue to explore the utility for IL in managing dysphagia in this pediatric population.
The relationship between patient‐reported and objective measures of physical function among cancer survivors receiving rehabilitation care: A correlation analysis
Authors: Oza Sonal , Kramer Andy , Ying Jian , Cushman Daniel M. 
Published: April 2024

AbstractBackgroundPhysical function is associated with cancer‐related quality of life and survival. The correlation of patient‐reported and objective measures of physical function has not been quantified previously in the cancer rehabilitation medicine setting.ObjectiveTo correlate patient‐reported physical function with objective measures of physical function. The secondary aim is to correlate fatigue and social participation levels with objective measures of physical function.DesignRetrospective.SettingTertiary university cancer center.ParticipantsA total of 226 cancer survivors referred to an outpatient cancer rehabilitation medicine clinic.InterventionNot applicable.Main Outcome MeasureCorrelation of Patient‐Reported Outcomes Measurement Information System (PROMIS) Cancer Function Brief 3D Profile domains with objective physical function measured by the 30‐second sit‐to‐stand and hand grip strength.ResultsPearson correlation analysis revealed a moderate correlation between patient‐reported physical function and the 30‐second sit‐to‐stand test (r = 0.57; p <.001), and a weak correlation of patient‐reported physical function and handgrip strength (r = 0.27; p <.001). Multivariable regression modeling controlling for age, gender, and receipt of systemic therapy demonstrated a significant association between patient‐reported physical function and the 30‐second sit‐to‐stand test (estimated confidence interval 0.76 [0.60, 0.92], p < .01), in addition to patient‐reported function and handgrip strength (estimated 0.22 [0.10, 0.34], p < .01). Multiple myeloma but no other cancer type was inversely associated with lower physical function.ConclusionsPatient‐reported physical function correlated moderately with the 30‐second sit‐to‐stand test, whereas hand grip strength demonstrated a weak correlation. The 30‐second sit‐to‐stand test is a suitable substitute for patient‐reported physical function. Further work evaluating how measures relate to each other across cancer populations is needed before recommending a standardized set of outcome measures.
Effects of EB irradiation on the properties of xanthan in solid state for utilization as adjuvant to improve foliar applications
Authors: Van Binh Nguyen , Quynh Tran Minh , An Tran Xuan , Thao Hoang Phuong , Diep Tran Bang 
Published: April 2024

AbstractIn this study, xanthan was irradiated by electron beam accelerator (EB) in solid state and the viscosity and molecular weight of the irradiated xanthan were investigated to provide a better understanding on the EB radiation effect on molecular properties of xanthan. Both viscosity and molecular weight of xanthan were greatly decreased by EB at 25 kGy then slowly decreased with further increase of irradiation dose to 200 kGy. Contact angles and adhesion degrees of the irradiated xanthan solutions were rather smaller than those of commercial xanthan. These results suggested that the xanthan was EB irradiated at 100 kGy can be utilized as a good adjuvant to improve spraying application of foliar fertilizer for promoting the growth and yield of water spinach.
Introduction: Stable Isotope Tracers Used for the Identification of Contaminants in Agro-Ecosystems
Authors: Skrzypek G. , Adu-Gyamfi J. , Imfeld G. , Heng L. 
Published: April 2024

AbstractThis chapter provides an overview of the stable isotope tracers used in agro-contaminant studies, summarizing essential information about each tracer, including the range of values, sample collection and preparation, and the most common applications. The chapter provides an overview of the book’s concept and contents and refers readers to the chapters of interest.
Savanna chimpanzee (Pan troglodytes) crop feeding at Dindefelo, Senegal: challenges and implications for conservation
Authors: Dotras Laia , Barciela Amanda , Llana Manuel , Galbany Jordi , Hernandez-Aguilar R. Adriana 
Published: April 2024

AbstractChimpanzees (Pan troglodytes) are categorized as Endangered by the International Union for Conservation of Nature, and habitat loss due to conversion of land for agriculture is one of the major threats to wild populations of this species. This challenging scenario can lead to negative human-chimpanzee interactions, including crop feeding. Chimpanzees consume crops across their geographical range, although little is known about this behavior in savanna habitats. Here we provide new evidence of crop feeding by savanna chimpanzees. We conducted our observations at Dindefelo, a community nature reserve in southeastern Senegal. The chimpanzees were observed to feed on mango (Mangifera indica) and also on baobab (Adansonia digitata), a wild species considered a crop by local people when found in and around villages. Although local people use the fruits of these species for food and income, they tolerated crop-feeding events until recently. In 2023, a case of harassment of a crop-feeding chimpanzee in a mango orchard was witnessed, and four days later a chimpanzee corpse was found at the same place. We conclude that habitat conversion into agricultural fields, uncontrolled bush fires and extraction of wild fruits are the important factors influencing crop-feeding events at Dindefelo. Our findings highlight the need to better understand human-chimpanzee interactions in the anthropogenic landscape of Dindefelo to help mitigate negative attitudes and behaviors towards chimpanzees.
ZAP70: A Key Gene Identified by Differential Expression Analysis for Early Diagnosis of Fetuses with Emanuel Syndrome
Authors: Hu Jing , Wang Mengyue , Xiang Ruiyao 
Published: April 2024

AbstractEmanuel syndrome is a rare autosomal disorder characterized by microcephaly, heart defects, cleft palate and developmental delay. However, there is a lack of specific prenatal screening for Emanuel syndrome. To screen for early diagnostic marker genes in fetuses with karyotype+der[22]t(11;22)(q23;q11) of Emanuel syndrome. Transcriptome sequencing and clinical trait data of t(11;22)(q23;q11) translocation samples were screened from the GEO database. The differentially expressed genes (DEGs) were screened by principal component analysis of gene expression by R package, and intersections were taken with balanced and unbalanced DEGs. Then, the correlation with clinical traits was determined by WGCNA analysis, GO and KEGG enrichment analysis, and then univariate Cox analysis and Lasso analysis were performed to obtain the key genes. The core regulatory genes were obtained after protein–protein interaction (PPI) network analysis. A total of 50 DEGs were obtained after differential analysis. WGCNA analysis showed that DEG was associated with the chromosomal imbalance and age module. GO and KEGG enrichment analyses showed candidate genes were associated with exocytic vesicle membrane, synaptic vesicle membranes, glycoprotein complex, dystrophin-associated glycoprotein complex and malaria. COX and Lasso analyses yielded 5 hub genes, including ZBED9, RGS20, SGCB, ETV5, and ZAP70. The results of PPI identified the key regulatory gene associated with chromosomal imbalance as the ZAP70 gene. ZAP70 may be a key gene for early diagnosis of Emanuel syndrome in fetuses with+der[22]t(11;22)(q23;q11) karyotype.
Driving sustainability in organizations: polymathic responsible leadership and circular economy
Authors: Wihler Andreas , Nolan Ryan C. , Zheng Yaxin , Inceoglu Ilke , Leroy Hannes , Charnley Fiona 
Published: April 2024

AbstractIssues around environmental sustainability have significantly increased in importance in both management practice and scholarship. One approach to address these is the transformative concept of the circular economy, which offers an alternative to traditional models of production and consumption. With organizations starting to adopt circular economy models and principles, the pivotal role of leaders in reshaping organizational practices from linear to circular approaches has begun to emerge. In this paper we introduce a novel perspective on responsible leadership emphasizing the need for a polymathic approach to address sustainability and apply this to the context of the circular economy. Viewing responsibility in leadership through a meta-taxonomy of effective leadership orientations, we apply our framework to a case study and illustrate its usefulness in guiding research and practice in the area of sustainability within organizations.
Problem solving in mathematics education: tracing its foundations and current research-practice trends
Authors: Santos-Trigo Manuel 
Published: April 2024

AbstractIn tracing recent research trends and directions in mathematical problem-solving, it is argued that advances in mathematics practices occur and take place around two intertwined activities, mathematics problem formulation and ways to approach and solve those problems. In this context, a problematizing principle emerges as central activity to organize mathematics curriculum proposals and ways to structure problem-solving learning environments. Subjects’ use of concrete, abstract, symbolic, or digital tools not only influences the ways to pose and pursue mathematical problems; but also shapes the type of representation, exploration, and reasoning they engage to work and solve problems. Problem-solving foundations that privilege learners’ development of habits of mathematical practices that involve an inquiry method to formulate conjectures, to look for different ways to represent and approach problems, and to support and communicate results shed light on directions of current research trends and the relevance of rethinking curriculum proposals and extending problem-solving environments in terms of teachers/students’ consistent use of digital tools and online developments.
The molecular tumor board—a key element of precision oncology
Authors: Boos Laura , Wicki Andreas 
Published: April 2024

SummaryTumor profiling techniques have become an essential tool in cancer diagnostics creating an opportunity for individualized cancer care. Interpretation of results of molecular analyses and their integration into clinical practice, however, can be challenging. Molecular tumor boards play a key role in translating molecular findings into cancer treatment recommendations. In this short review we address important questions regarding the molecular tumor board set-up and highlight aspects of interest and challenges ahead.
Business text classification with imbalanced data and moderately large label spaces for digital transformation
Authors: Arslan Muhammad , Cruz Christophe 
Published: April 2024

AbstractDigital transformation refers to an organization’s use of digital technology to improve its products, services, and operations, aligning them with evolving business requirements. To demonstrate this transformative process, we present a real-life case study where a company seeks to automate the classification of their textual data rather than relying on manual methods. Transitioning to automated classification involves deploying machine learning models, which rely on pre-labeled datasets for training and making predictions on new data. However, upon receiving the dataset from the company, we faced challenges due to the imbalanced distribution of labels and moderately large label spaces. To tackle text classification with such a business dataset, we evaluated four distinct methods for multi-label text classification: fine-tuned Bidirectional Encoder Representations from Transformers (BERT), Binary Relevance, Classifier Chains, and Label Powerset. The results revealed that fine-tuned BERT significantly outperformed the other methods across key metrics like Accuracy, F1-score, Precision, and Recall. Binary Relevance also displayed competence in handling the dataset effectively, while Classifier Chains and Label Powerset exhibited comparatively less impressive performance. These findings highlight the remarkable effectiveness of fine-tuned BERT model and the Binary Relevance classifier in multi-label text classification tasks, particularly when dealing with imbalanced training datasets and moderately large label spaces. This positions them as valuable assets for businesses aiming to automate data classification in the digital transformation era.
Insights into chloroplast genome evolution in Rutaceae through population genomics
Authors: Li Chao-Chao , Bao Yi , Hou Ting , Li Jia-Cui , Ma Zhi-Yao , Wang Nan , Wu Xiao-Meng , Xie Kai-Dong , Zhou Yong-Feng , Guo Wen-Wu 
Published: April 2024

AbstractChloroplast genomes, pivotal for understanding plant evolution, remain unexplored in Rutaceae, a family with key perennial crops like citrus. Leveraging next-generation sequencing data from 509 Rutaceae accessions across 15 species, we conducted a de novo assembly of 343 chloroplast genomes, unveiling a chloroplast variation map highlighting the heterogeneous evolution rates across genome regions. Notably, differences in chloroplast genome size primarily originate from large single-copy and small single-copy regions. Structural variants predominantly occurred in the single-copy region, with two insertions located at the single-copy and inverted repeat region boundary. Phylogenetic analysis, principal component analysis, and population genetic statistics confirmed the cohesive clustering of different Citrus species, reflecting evolutionary dynamics in Citrus diversification. Furthermore, a close chloroplast genetic affinity was revealed among Atalantia (previously regarded as primitive citrus), Clausena, and Murraya. Zanthoxylum formed a distinct group with heightened genetic diversity. Through expanding our analysis to include 34 published chloroplast genomes, we explored chloroplast gene selection, revealing divergent evolutionary trends in photosynthetic pathways. While Photosystem I and Photosystem II exhibited robust negative selection, indicating stability, the Nicotinamide adenine dinucleotide (NADH) dehydrogenase pathway demonstrated rapid evolution, which was indicative of environmental adaptation. Finally, we discussed the effects of gene length and GC content on chloroplast gene evolution. In conclusion, our study reveals the genetic characterization of chloroplast genomes during Rutaceae diversification, providing insights into the evolutionary history of this family.
Integrating Tehran metropolitan air pollution into the current transport system and sprawl growth: an emphasis on urban performance and accessibility
Authors: Talkhabi Hamidreza , Jafarpour Ghalehteimouri Kamran , Toulabi Nejad Meysam 
Published: April 2024

AbstractAir pollution is one of the most challenging issues for urban environment and environmental management. The goal of this study was to determine the impact of Tehran metropolitan's performance and accessibility on urban transportation and air pollution as sprawl grows. Tehran, with a population of 15.98 million people, has many environmental issues, including air pollution. Secondary data were collected from the Tehran Air Quality Control Company as well as Landsat satellite imagery (OLI). The raw data of intra-city and suburban traffic counts for spatial analysis of movements, combined with the raw data of measuring stations, were then used as a sample in the ArcGIS software environment for three selected days in 2013, 2014, and 2016. Following geometric and radiometric correction, programming methods and a multivariate regression algorithm were applied to the images, yielding results in the form of additional stations. According to the results obtained (about 3.29 m) root-mean-square error (RMSE), the Inverse Distance Weighting (IDW) model was used in air pollution maps for better assessment. The findings suggest that Tehran is not the only source of air pollution and that TMA performance and accessibility play a significant role in the amount of air pollution. Furthermore, there is a strong correlation (more than 75%) between air pollution maps and transportation flow maps on specific days (February 23, 2013, February 26, 2015, and December 28, 2016). Finally, the analysis of this situation in three circles showed that the highest volume of traffic was done in the city of Tehran (CBD), suburban area (Suburban), and suburban area (Exurban), respectively, and the pattern of distribution and spatial accumulation of pollution has also been a function of this situation.
Social Group Moral Encroachment
Authors: Mitova Veli 
Published: April 2024

AbstractAccording to moral encroachers, the moral stakes of a belief partly determine how much evidence we need for the belief to count as knowledge. This view concerns the beliefs of individual believers. In this paper, I argue for a social group version of moral encroachment: dominant groups, such as white people or men, need to have more evidence than the marginalised in order for some of their beliefs to constitute knowledge. I argue for this claim in three steps. First, I spell out the group moral stakes involved – the harms dominant knowers cause the marginalised and the knowledge economy. Second, I show off the theoretical benefits of having the notion of social group moral encroachment at our disposal: it can be an invaluable tool for decolonial and feminist epistemologists if they want to avoid the relativistic ring to their views (a ring that tends to put off many well-wishers). Finally, I start on a positive account of social group moral encroachment by addressing a potential puzzle and responding to objections.
The study of Italian regional politics and the composition of the regional political class. The ITREGPARL dataset
Authors: Pansardi Pamela , Baraldi Francesco , Salvati Eugenio 
Published: April 2024

AbstractOne of the most persistent challenges in the study of regional politics in Italy is the lack of systematized data and information about the composition of regional legislatures and governments and the profiles of elected officials. In this paper, we describe the ITREGPARL dataset, a new comprehensive dataset of Italian regional politics comprising 6077 regional politicians from 1993 to 2020. It includes information about regional councillors, regional ministers, presidents and vice-presidents of the regional council, regional presidents and vice-presidents. Along with socio-demographic characteristics – gender, age, previous profession, education – it includes data such as experience and incumbency, number of mandates, length of service and partisanship. It also includes region-level variables, such as geographical area, type of gender quotas and the regional authority index.