bluuebunny/crossref_metadata_2025_split huggingface dataset:
Softness‐Aided Mild Hyperthermia Boosts Stiff Nanomedicine by Regulating Tumor Mechanics
Authors: Li Zheng , Zhu Yabo , Zhang Zhijie , Wang Huimin , Wang Chong , Xu Chen , Li Shiyou , Zhang Shuya , Yang Xiangliang , Li Zifu 
Published: May 2024

AbstractAberrant tumor mechanical microenvironment (TMME), featured with overactivated cancer‐associated fibroblasts (CAFs) and excessive extracellular matrix (ECM), severely restricts penetration and accumulation of cancer nanomedicines, while mild‐hyperthermia photothermal therapy (mild‐PTT) has been developed to modulate TMME. However, photothermal agents also encounter the barriers established by TMME, manifesting in limited penetration and heterogeneous distribution across tumor tissues and ending with attenuated efficiency in TMME regulation. Herein, it is leveraged indocyanine green (ICG)‐loaded soft nanogels with outstanding deformability, for efficient tumor penetration and uniform distribution, in combination with mild‐PTT to achieve potent TMME regulation by inhibiting CAFs and degrading ECM. As a result, doxorubicin (DOX)‐loaded stiff nanogels gain greater benefits in tumor penetration and antitumor efficacy than soft counterparts from softness‐mediated mild‐PTT. This study reveals the crucial role of nanomedicine mechanical properties in tumor distribution and provides a novel strategy for overcoming the barriers of solid tumors with soft deformable nanogels.
Integrating Computational and Biological Hemodynamic Approaches to Improve Modeling of Atherosclerotic Arteries
Authors: Vuong Thao Nhu Anne Marie , Bartolf‐Kopp Michael , Andelovic Kristina , Jungst Tomasz , Farbehi Nona , Wise Steven G. , Hayward Christopher , Stevens Michael Charles , Rnjak‐Kovacina Jelena 
Published: May 2024

AbstractAtherosclerosis is the primary cause of cardiovascular disease, resulting in mortality, elevated healthcare costs, diminished productivity, and reduced quality of life for individuals and their communities. This is exacerbated by the limited understanding of its underlying causes and limitations in current therapeutic interventions, highlighting the need for sophisticated models of atherosclerosis. This review critically evaluates the computational and biological models of atherosclerosis, focusing on the study of hemodynamics in atherosclerotic coronary arteries. Computational models account for the geometrical complexities and hemodynamics of the blood vessels and stenoses, but they fail to capture the complex biological processes involved in atherosclerosis. Different in vitro and in vivo biological models can capture aspects of the biological complexity of healthy and stenosed vessels, but rarely mimic the human anatomy and physiological hemodynamics, and require significantly more time, cost, and resources. Therefore, emerging strategies are examined that integrate computational and biological models, and the potential of advances in imaging, biofabrication, and machine learning is explored in developing more effective models of atherosclerosis.
Development of a Specific Aptamer‐Modified Nano‐System to Treat Esophageal Squamous Cell Carcinoma
Authors: Xie Fei , Qiu Jinrong , Sun Congyong , Feng Lulu , Jun Yali , Luo Chao , Guo Xiamei , Zhang Bowei , Zhou Yu , Wang Yuting , Zhang Li , Wang Qilong 
Published: May 2024

AbstractEsophageal squamous cell carcinoma (ESCC) is a prevalent gastrointestinal cancer characterized by high mortality and an unfavorable prognosis. While combination therapies involving surgery, chemotherapy, and radiation therapy are advancing, targeted therapy for ESCC remains underdeveloped. As a result, the overall five‐year survival rate for ESCC is still below 20%. Herein, ESCC‐specific DNA aptamers and an innovative aptamer‐modified nano‐system is introduced for targeted drug and gene delivery to effectively inhibit ESCC. The EA1 ssDNA aptamer, which binds robustly to ESCC cells with high specificity and affinity, is identified using cell‐based systematic evolution of ligands by exponential enrichment (cell‐SELEX). An EA1‐modified nano‐system is developed using a natural egg yolk lipid nanovector (EA1‐EYLNs‐PTX/siEFNA1) that concurrently loads paclitaxel (PTX) and a small interfering RNA of Ephrin A1 (EFNA1). This combination counters ESCC's proliferation, migration, invasion, and lung metastasis. Notably, EFNA1 is overexpressed in ESCC tumors with lung metastasis and has an inverse correlation with ESCC patient prognosis. The EA1‐EYLNs‐PTX/siEFNA1 nano‐system offers effective drug delivery and tumor targeting, resulting in significantly improved therapeutic efficacy against ESCC tumors. These insights suggest that aptamer‐modified nano‐systems can deliver drugs and genes with superior tumor‐targeting, potentially revolutionizing targeted therapy in ESCC.
A MXene Hydrogel‐Based Versatile Microrobot for Controllable Water Pollution Management
Authors: Yang Kuo , Dong Qianqian , Liu Hang , Wu Lei , Zong Shenfei , Wang Zhuyuan 
Published: May 2024

AbstractThe urgent demand for addressing dye contaminants in water necessitates the development of microrobots that exhibit remote navigation, rapid removal, and molecular identification capabilities. The progress of microrobot development is currently hindered by the scarcity of multifunctional materials. In this study, a plasmonic MXene hydrogel (PM‐Gel) is synthesized by combining bimetallic nanocubes and Ti3C2Tx MXene through the rapid gelation of degradable alginate. The hydrogel can efficiently adsorb over 60% of dye contaminants within 2 min, ultimately achieving a removal rate of >90%. Meanwhile, the hydrogel exhibits excellent sensitivity in surface enhanced Raman scattering (SERS) detection, with a limit of detection (LOD) as low as 3.76 am. The properties of the plasmonic hydrogel can be further adjusted for various applications. As a proof‐of‐concept experiment, thermosensitive polymers and superparamagnetic particles are successfully integrated into this hydrogel to construct a versatile, light‐responsive microrobot for dye contaminants. With magnetic and optical actuation, the robot can remotely sample, identify, and remove pollutants in maze‐like channels. Moreover, light‐driven hydrophilic‐hydrophobic switch of the microrobots through photothermal effect can further enhance the adsorption capacity and reduced the dye residue by up to 58%. These findings indicate of a broad application potential in complex real‐world environments.
Ultrapotent Broadly Neutralizing Human‐llama Bispecific Antibodies against HIV‐1
Authors: Xu Jianliang , Zhou Tongqing , McKee Krisha , Zhang Baoshan , Liu Cuiping , Nazzari Alexandra F. , Pegu Amarendra , Shen Chen‐Hsiang , Becker Jordan E. , Bender Michael F. , Chan Payton , Changela Anita , Chaudhary Ridhi , Chen Xuejun , Einav Tal , Kwon Young Do , Lin Bob C. , Louder Mark K. , Merriam Jonah S. , Morano Nicholas C. , O'Dell Sijy , Olia Adam S. , Rawi Reda , Roark Ryan S. , Stephens Tyler , Teng I‐Ting , Tourtellott‐Fogt Emily , Wang Shuishu , Yang Eun Sung , Shapiro Lawrence , Tsybovsky Yaroslav , Doria‐Rose Nicole A. , Casellas Rafael , Kwong Peter D. 
Published: May 2024

AbstractBroadly neutralizing antibodies are proposed as therapeutic and prophylactic agents against HIV‐1, but their potency and breadth are less than optimal. This study describes the immunization of a llama with the prefusion‐stabilized HIV‐1 envelope (Env) trimer, BG505 DS‐SOSIP, and the identification and improvement of potent neutralizing nanobodies recognizing the CD4‐binding site (CD4bs) of vulnerability. Two of the vaccine‐elicited CD4bs‐targeting nanobodies, G36 and R27, when engineered into a triple tandem format with llama IgG2a‐hinge region and human IgG1‐constant region (G36×3‐IgG2a and R27×3‐IgG2a), neutralized 96% of a multiclade 208‐strain panel at geometric mean IC80s of 0.314 and 0.033 µg mL−1, respectively. Cryo‐EM structures of these nanobodies in complex with Env trimer revealed the two nanobodies to neutralize HIV‐1 by mimicking the recognition of the CD4 receptor. To enhance their neutralizing potency and breadth, nanobodies are linked to the light chain of the V2‐apex‐targeting broadly neutralizing antibody, CAP256V2LS. The resultant human‐llama bispecific antibody CAP256L‐R27×3LS exhibited ultrapotent neutralization and breadth exceeding other published HIV‐1 broadly neutralizing antibodies, with pharmacokinetics determined in FcRn‐Fc mice similar to the parent CAP256V2LS. Vaccine‐elicited llama nanobodies, when combined with V2‐apex broadly neutralizing antibodies, may therefore be able to fulfill anti‐HIV‐1 therapeutic and prophylactic clinical goals.
Sex‐Specific Association Between Childhood Adversity and Accelerated Biological Aging
Authors: Yu Jie , Pu Fan , Yang Gan , Hao Meng , Zhang Hui , Zhang Jingyun , Cao Xingqi , Zhu Lijun , Wan Yuhui , Wang Xiaofeng , Liu Zuyun 
Published: May 2024

AbstractIs childhood adversity associated with biological aging, and if so, does sex modify the association, and do lifestyle and mental health mediate the association? A lifespan analysis is conducted using data on 142 872 participants from the UK Biobank to address these questions. Childhood adversity is assessed through the online mental health questionnaire (2016), including physical neglect, physical abuse, emotional neglect, emotional abuse, sexual abuse, and a cumulative score. Biological aging is indicated by telomere length (TL) measured from leukocyte DNA using qPCR, and the shorter TL indicates accelerated biological aging; a lifestyle score is constructed using body mass index, physical activity, drinking, smoking, and diet; mental disorder is assessed using depression, anxiety, and insomnia at the baseline survey. The results reveal a sex‐specific association such that childhood adversity is associated with shorter TL in women after adjusting for covariates including polygenic risk score for TL, but not in men. Unhealthy lifestyle and mental disorder partially mediate the association in women. The proportions of indirect effects are largest for sexual and physical abuse. These findings highlight the importance of behavioral and psychological interventions in promoting healthy aging among women who experienced childhood adversity, particularly sexual and physical abuse.
Scanning Electron Microscopy Imaging of Large DNA Molecules Using a Metal‐Free Electro‐Stain Composed of DNA‐Binding Proteins and Synthetic Polymers
Authors: Noh Chanyoung , Kang Yoonjung , Heo Sujung , Kim Taesoo , Kim Hayeon , Chang Junhyuck , Sundharbaabu Priyannth Ramasami , Shim Sanghee , Lim Kwang‐il , Lee Jung Heon , Jo Kyubong 
Published: May 2024

AbstractThis paper presents the first scanning electron microscopy (SEM)‐based DNA imaging in biological samples. This novel approach incorporates a metal‐free electro‐stain reagent, formulated by combining DNA‐binding proteins and synthetic polymers to enhance the visibility of 2‐nm‐thick DNA under SEM. Notably, DNA molecules stain with proteins and polymers appear as dark lines under SEM. The resulting DNA images exhibit a thickness of 15.0±4.0 nm. As SEM is the primary platform, it integrates seamlessly with various chemically functionalized large surfaces with the aid of microfluidic devices. The approach allows high‐resolution imaging of various DNA structures including linear, circular, single‐stranded DNA and RNA, originating from nuclear and mitochondrial genomes. Furthermore, quantum dots are successfully visualized as bright labels that are sequence‐specifically incorporated into DNA molecules, which highlights the potential for SEM‐based optical DNA mapping. In conclusion, DNA imaging using SEM with the novel electro‐stain offers electron microscopic resolution with the ease of optical microscopy.
Mitochondria‐Targeted Nanoadjuvants Induced Multi‐Functional Immune‐Microenvironment Remodeling to Sensitize Tumor Radio‐Immunotherapy
Authors: Zhou Zaigang , Li Cheng , Li Chao , Zhou Lei , Tan Shuo , Hou Weibin , Xie Congying , Wang Long , Shen Jianliang , Xiong Wei 
Published: May 2024

AbstractIt is newly revealed that collagen works as a physical barrier to tumor immune infiltration, oxygen perfusion, and immune depressor in solid tumors. Meanwhile, after radiotherapy (RT), the programmed death ligand‐1 (PD‐L1) overexpression and transforming growth factor‐β (TGF‐β) excessive secretion would accelerate DNA damage repair and trigger T cell exclusion to limit RT efficacy. However, existing drugs or nanoparticles can hardly address these obstacles of highly effective RT simultaneously, effectively, and easily. In this study, it is revealed that inducing mitochondria dysfunction by using oxidative phosphorylation inhibitors like Lonidamine (LND) can serve as a highly effective multi‐immune pathway regulation strategy through PD‐L1, collagen, and TGF‐β co‐depression. Then, IR‐LND is prepared by combining the mitochondria‐targeted molecule IR‐68 with LND, which then is loaded with liposomes (Lip) to create IR‐LND@Lip nanoadjuvants. By doing this, IR‐LND@Lip more effectively sensitizes RT by generating more DNA damage and transforming cold tumors into hot ones through immune activation by PD‐L1, collagen, and TGF‐β co‐inhibition. In conclusion, the combined treatment of RT and IR‐LND@Lip ultimately almost completely suppressed the growth of bladder tumors and breast tumors.
HydrogelFinder: A Foundation Model for Efficient Self‐Assembling Peptide Discovery Guided by Non‐Peptidal Small Molecules
Authors: Ren Xuanbai , Wei Jiaying , Luo Xiaoli , Liu Yuansheng , Li Kenli , Zhang Qiang , Gao Xin , Yan Sizhe , Wu Xia , Jiang Xingyue , Liu Mingquan , Cao Dongsheng , Wei Leyi , Zeng Xiangxiang , Shi Junfeng 
Published: May 2024

AbstractSelf‐assembling peptides have numerous applications in medicine, food chemistry, and nanotechnology. However, their discovery has traditionally been serendipitous rather than driven by rational design. Here, HydrogelFinder, a foundation model is developed for the rational design of self‐assembling peptides from scratch. This model explores the self‐assembly properties by molecular structure, leveraging 1,377 self‐assembling non‐peptidal small molecules to navigate chemical space and improve structural diversity. Utilizing HydrogelFinder, 111 peptide candidates are generated and synthesized 17 peptides, subsequently experimentally validating the self‐assembly and biophysical characteristics of nine peptides ranging from 1–10 amino acids—all achieved within a 19‐day workflow. Notably, the two de novo‐designed self‐assembling peptides demonstrated low cytotoxicity and biocompatibility, as confirmed by live/dead assays. This work highlights the capacity of HydrogelFinder to diversify the design of self‐assembling peptides through non‐peptidal small molecules, offering a powerful toolkit and paradigm for future peptide discovery endeavors.
Electron Manipulation and Surface Reconstruction of Bimetallic Iron–Nickel Phosphide Nanotubes for Enhanced Alkaline Water Electrolysis
Authors: Wang Xinqiang , Zhou Jinhao , Cui Wengang , Gao Fan , Gao Yong , Qi Fulai , Liu Yanxia , Yang Xiaoying , Wang Ke , Li Zhenglong , Yang Yaxiong , Chen Jian , Sun Wenping , Sun Lixian , Pan Hongge 
Published: May 2024

AbstractDeveloping high‐efficiency and stable bifunctional electrocatalysts for water splitting remains a great challenge. Herein, NiMoO4 nanowires as sacrificial templates to synthesize Mo‐doped NiFe Prussian blue analogs are employed, which can be easily phosphorized to Mo‐doped Fe2xNi2(1‐x)P nanotubes (Mo‐FeNiP NTs). This synthesis method enables the controlled etching of NiMoO4 nanowires that results in a unique hollow nanotube architecture. As a bifunctional catalyst, the Mo‐FeNiP NTs present lower overpotential and Tafel slope of 151.3 (232.6) mV at 100 mA cm−2 and 76.2 (64.7) mV dec−1 for HER (OER), respectively. Additionally, it only requires an ultralow cell voltage of 1.47 V to achieve 10 mA cm−2 for overall water splitting and can steadily operate for 200 h at 100 mA cm−2. First‐principles calculations demonstrate that Mo doping can effectively adjust the electron redistribution of the Ni hollow sites to optimize the hydrogen adsorption‐free energy for HER. Besides, in situ Raman characterization reveals the dissolving of doped Mo can promote a rapid surface reconstruction on Mo‐FeNiP NTs to dynamically stable (Fe)Ni‐oxyhydroxide layers, serving as the actual active species for OER. The work proposes a rational approach addressed by electron manipulation and surface reconstruction of bimetallic phosphides to regulate both the HER and OER activity.
High‐Performance Aluminum Fuels Induced by Monolayer Self‐Assembly of Nano‐Sized Energetic Fluoride Vesicles on the Surface
Authors: Wang Ruibin , Zhang Lichen , Li Xiaodong , Zhu Lixiang , Xiang Zilong , Xu Jin , Xue Dichang , Deng Zitong , Su Xing , Zou Meishuai 
Published: May 2024

AbstractSurface modification is frequently used to solve the problems of low combustion properties and agglomeration for aluminum‐based fuels. However, due to the intrinsic incompatibility between the aluminum powder and the organic modifiers, the surface coating is usually uneven and disordered, which significantly deteriorates the uniformity and performances of the Al‐based fuels. Herein, a new approach of monolayer nano‐vesicular self‐assembly is proposed to prepare high‐performance Al fuels. Triblock copolymer G‐F‐G is produced by glycidyl azide polymer (GAP) and 2,2′‐(2,2,3,3,4,5,5‐Octafluorohexane‐1,6‐diyl) bis (oxirane) (fluoride) ring‐open addition reaction. By utilizing G‐F‐G vesicular self‐assembly in a special solvent, the nano‐sized vesicles are firmly adhered to the surface of Al powder through the long‐range attraction between the fluorine segments and Al. Meanwhile, the electrostatic repulsion between vesicles ensures an extremely thin coating thickness (≈15 nm), maintaining the monolayer coating structure. Nice ignition, combustion, anti‐agglomeration, and water‐proof properties of Al@G‐F‐G(DMF) are achieved, which are superior among the existing Al‐based fuels. The derived Al‐based fuel has excellent comprehensive properties, which can not only inspire the development of new‐generation energetic materials but also provide facile but exquisite strategies for exquisite surface nanostructure construction via ordered self‐assembly for many other applications.
Stepwise Toward Pure Blue Organic Light‐Emitting Diodes by Synergetically Locking and Shielding Carbonyl/Nitrogen‐Based MR‐TADF Emitters
Authors: Yu Jie‐Rong , Tan Hong‐Ji , Gao Xiu‐Qi , Wang Bing , Long Zhi‐Qiang , Liu Jia‐Li , Lin Zhi‐Zhong , Li Xing‐Yi , Zhu Ze‐Lin , Jian Jing‐Xin , Tong Qing‐Xiao , Lee Chun‐Sing 
Published: May 2024

AbstractDeep‐blue multi‐resonance (MR) emitters with stable and narrow full‐width‐at‐half‐maximum (FWHM) are of great importance for widening the color gamut of organic light‐emitting diodes (OLEDs). However, most planar MR emitters are vulnerable to intermolecular interactions from both the host and guest, causing spectral broadening and exciton quenching in thin films. Their emission in the solid state is environmentally sensitive, and the color purity is often inferior to that in solutions. Herein, a molecular design strategy is presented that simultaneously narrows the FWHM and suppresses intermolecular interactions by combining intramolecular locking and peripheral shielding within a carbonyl/nitrogen‐based MR core. Intramolecularly locking carbonyl/nitrogen‐based bears narrower emission of 2,10‐dimethyl‐12,12‐diphenyl‐4H‐benzo[9,1]quinolizino[3,4,5,6,7‐defg]acridine‐4,8(12H)‐dione in solution and further with peripheral‐shielding groups, deep‐blue emitter (12,12‐diphenyl‐2,10‐bis(9‐phenyl‐9H‐fluoren‐9‐yl)−4H‐benzo[9,1]quinolizino[3,4,5,6,7‐defg]acridine‐4,8(12H)‐dione, DPQAO‐F) exhibits ultra‐pure emission with narrow FWHM (c.a., 24 nm) with minimal variations (∆FWHM ≤ 3 nm) from solution to thin films over a wide doping range. An OLED based on DPQAO‐F presents a maximum external quantum efficiency (EQEmax) of 19.9% and color index of (0.134, 0.118). Furthermore, the hyper‐device of DPQAO‐F exhibits a record‐high EQEmax of 32.7% in the deep‐blue region, representing the first example of carbonyl/nitrogen‐based OLED that can concurrently achieve narrow bandwidth in the deep‐blue region and a high electroluminescent efficiency surpassing 30%.
Self‐Powered Autonomous Electrostatic Dust Removal for Solar Panels by an Electret Generator
Authors: Ding Rong , Cao Zeyuan , Teng Junchi , Cao Yujia , Qian Xiaoyu , Yue Wei , Yuan Xiangzhu , Deng Kang , Wu Zibo , Li Shuiqing , Lin Liwei , Ye Xiongying 
Published: May 2024

AbstractSolar panels often suffer from dust accumulation, significantly reducing their output, especially in desert regions where many of the world's largest solar plants are located. Here, an autonomous dust removal system for solar panels, powered by a wind‐driven rotary electret generator is proposed. The generator applies a high voltage between one solar panel's output electrode and an upper mesh electrode to generate a strong electrostatic field. It is discovered that dust particles on the insulative glass cover of the panel can be charged under the high electrical field, assisted by adsorbed water, even in low‐humidity environments. The charged particles are subsequently repelled from the solar panel with the significant Coulomb force. Two panels covered with sand dust are cleaned in only 6.6 min by a 15 cm diameter rotary electret generator at 1.6 m s−1wind speed. Experimental results manifest that the system can work effectively in a wide range of environmental conditions, and doesn't impact the panel performance for long‐term operation. This autonomous system, with its high dust removal efficiency, simplicity, and low cost, holds great potential in practical applications.
The Long Non‐Coding RNA Obesity‐Related (Obr) Contributes To Lipid Metabolism Through Epigenetic Regulation
Authors: Kaimala Suneesh , Lootah Shareena Saeed , Mehra Neha , Kumar Challagandla Anil , Marzooqi Saeeda Al , Sampath Prabha , Ansari Suraiya Anjum , Emerald Bright Starling 
Published: May 2024

AbstractObesity is a multifactorial disease that is part of today's epidemic and also increases the risk of other metabolic diseases. Long noncoding RNAs (lncRNAs) provide one tier of regulatory mechanisms to maintain metabolic homeostasis. Although lncRNAs are a significant constituent of the mammalian genome, studies aimed at their metabolic significance, including obesity, are only beginning to be addressed. Here, a developmentally regulated lncRNA, termed as obesity related (Obr), whose expression in metabolically relevant tissues such as skeletal muscle, liver, and pancreas is altered in diet‐induced obesity, is identified. The Clone 9 cell line and high‐fat diet‐induced obese Wistar rats are used as a model system to verify the function of Obr. By using stable expression and antisense oligonucleotide‐mediated downregulation of the expression of Obr followed by different molecular biology experiments, its role in lipid metabolism is verified. It is shown that Obr associates with the cAMP response element‐binding protein (Creb) and activates different transcription factors involved in lipid metabolism. Its association with the Creb histone acetyltransferase complex, which includes the cAMP response element‐binding protein (CBP) and p300, positively regulates the transcription of genes involved in lipid metabolism. In addition, Obr is regulated by Pparγ in response to lipid accumulation.