bluuebunny/crossref_metadata_2025_split huggingface dataset:
Room‐Temperature Solid‐State Nitrogen‐Based Magneto‐Ionics in CoxMn1−xN Films
Authors: López‐Pintó Nicolau , Jensen Christopher J. , Chen Zhijie , Tan Zhengwei , Ma Zheng , Liedke Maciej Oskar , Butterling Maik , Wagner Andreas , Herrero‐Martín Javier , Menéndez Enric , Nogués Josep , Liu Kai , Sort Jordi 
Published: May 2024

AbstractThe increasing energy demand in information technologies requires novel low‐power procedures to store and process data. Magnetic materials, central to these technologies, are usually controlled through magnetic fields or spin‐polarized currents that are prone to the Joule heating effect. Magneto‐ionics is a unique energy‐efficient strategy to control magnetism that can induce large non‐volatile modulation of magnetization, coercivity and other properties through voltage‐driven ionic motion. Recent studies have shown promising magneto‐ionic effects using nitrogen ions. However, either liquid electrolytes or prior annealing procedures are necessary to induce the desired N‐ion motion. In this work, magneto‐ionic effects are voltage‐triggered at room temperature in solid state systems of CoxMn1‐xN films, without the need of thermal annealing. Upon gating, a rearrangement of nitrogen ions in the layers is observed, leading to changes in the co‐existing ferromagnetic and antiferromagnetic phases, which result in substantial increase of magnetization at room temperature and modulation of the exchange bias effect at low temperatures. A detailed correlation between the structural and magnetic evolution of the system upon voltage actuation is provided. The obtained results offer promising new avenues for the utilization of nitride compounds in energy‐efficient spintronic and other memory devices.
Revealing Interaction of Fluorinated Propylamine Hydrochloride with Precursor and Defect States of Perovskite Films Toward Efficient Flexible Solar Cells
Authors: Cao Shuguang , Bi Zhuoneng , Zheng Tongjun , Luo Shizi , Gutsev Lavrenty G. , Ramachandran Bala R. , Ozerova Victoria V. , Emelianov Nikita A. , Slesarenko Nikita A. , Zheng Yupeng , Taye Biniyam Zemene , Gutsev Gennady L. , Aldoshin Sergey M. , Troshin Pavel A. , Xu Xueqing 
Published: May 2024

AbstractThe trap state at the surfaces and grain boundaries of perovskite is one of the major obstacles to the further commercialization of flexible perovskite solar cells (FPSCs). Herein, two innovative multifunctional fluorinated propylamine salt 2,2,3,3,3‐pentafluoropropylamine hydrochloride (PFPACl) and 3,3,3‐triflupropylamine hydrochloride (TFPACl) are in situ introduced onto the photo absorbing layer to improve the performance of the FPSCs. The nuclear magnetic resonance (NMR) spectroscopy indicates strong interactions of both PFPACl and TFPACl with the perovskite precursor components. For the first time, the structures of the supramolecular complexes formed by two additives with FAI are deduced from NOESY NMR data, thus pointing to the importance of the preorganization of the perovskite components in solution before film casting. The experiments and density functional theory（DFT) calculations reveal that PFPACl is likely dissociated more into the form of R‐NH3+‐Cl− due to the higher electronegativity of the fluoroalkyl tail. Therefore, PFPA+ binds more strongly to VFA defects than TFPA+, and anion Cl− has strong enough interaction with VFAI and uncoordinated Pb2+, leading to homogeneous coverage of PFPACl on the entire surface of the perovskite films and better energy alignment with the hole transport layer. Consequently, PFPACl‐treated FPSCs achieved a relatively high PCE of 23.59% with excellent mechanical robustness and operational stability.
3D Cell Migration Chip (3DCM‐Chip): A New Tool toward the Modeling of 3D Cellular Complex Systems
Authors: Buonvino Silvia , Di Giuseppe Davide , Filippi Joanna , Martinelli Eugenio , Seliktar Dror , Melino Sonia 
Published: May 2024

Abstract3D hydrogel‐based cell cultures provide models for studying cell behavior and can efficiently replicate the physiologic environment. Hydrogels can be tailored to mimic mechanical and biochemical properties of specific tissues and allow to produce gel‐in‐gel models. In this system, microspheres encapsulating cells are embedded in an outer hydrogel matrix, where cells are able to migrate. To enhance the efficiency of such studies, a lab‐on‐a‐chip named 3D cell migration‐chip (3DCM‐chip) is designed, which offers substantial advantages over traditional methods. 3DCM‐chip facilitates the analysis of biochemical and physical stimuli effects on cell migration/invasion in different cell types, including stem, normal, and tumor cells. 3DCM‐chip provides a smart platform for developing more complex cell co‐cultures systems. Herein the impact of human fibroblasts on MDA‐MB 231 breast cancer cells’ invasiveness is investigated. Moreover, how the presence of different cellular lines, including mesenchymal stem cells, normal human dermal fibroblasts, and human umbilical vein endothelial cells, affects the invasive behavior of cancer cells is investigated using 3DCM‐chip. Therefore, predictive tumoroid models with a more complex network of interactions between cells and microenvironment are here produced. 3DCM‐chip moves closer to the creation of in vitro systems that can potentially replicate key aspects of the physiological tumor microenvironment.
A Pseudo‐Surfactant Chemical Permeation Enhancer to Treat Otitis Media via Sustained Transtympanic Delivery of Antibiotics
Authors: Liu Sophie S. , White Joanna M. , Chao Zhongmou , Li Ruye , Wen Shuxian , Garza Ally , Tang Wenjing , Ma Xiaojing , Chen Pengyu , Daniel Susan , Bates Frank S. , Yeo Jingjie , Calabrese Michelle A. , Yang Rong 
Published: May 2024

AbstractChemical permeation enhancers (CPEs) represent a prevalent and safe strategy to enable noninvasive drug delivery across skin‐like biological barriers such as the tympanic membrane (TM). While most existing CPEs interact strongly with the lipid bilayers in the stratum corneum to create defects as diffusion paths, their interactions with the delivery system, such as polymers forming a hydrogel, can compromise gelation, formulation stability, and drug diffusion. To overcome this challenge, differing interactions between CPEs and the hydrogel system are explored, especially those with sodium dodecyl sulfate (SDS), an ionic surfactant and a common CPE, and those with methyl laurate (ML), a nonionic counterpart with a similar length alkyl chain. Notably, the use of ML effectively decouples permeation enhancement from gelation, enabling sustained delivery across TMs to treat acute otitis media (AOM), which is not possible with the use of SDS. Ciprofloxacin and ML are shown to form a pseudo‐surfactant that significantly boosts transtympanic permeation. The middle ear ciprofloxacin concentration is increased by 70‐fold in vivo in a chinchilla AOM model, yielding superior efficacy and biocompatibility than the previous highest‐performing formulation. Beyond improved efficacy and biocompatibility, this single‐CPE formulation significantly accelerates its progression toward clinical deployment.
Advances in Microfluidic‐Based Core@Shell Nanoparticles Fabrication for Cancer Applications
Authors: Almeida Duarte R. S. , Gil João Ferreira , Guillot Antonio José , Li Jiachen , Pinto Ricardo J. B. , Santos Hélder A. , Gonçalves Gil 
Published: May 2024

AbstractCurrent research in cancer therapy focuses on personalized therapies, through nanotechnology‐based targeted drug delivery systems. Particularly, controlled drug release with nanoparticles (NPs) can be designed to safely transport various active agents, optimizing delivery to specific organs and tumors, minimizing side effects. The use of microfluidics (MFs) in this field has stood out against conventional methods by allowing precise control over parameters like size, structure, composition, and mechanical/biological properties of nanoscale carriers. This review compiles applications of microfluidics in the production of core‐shell NPs (CSNPs) for cancer therapy, discussing the versatility inherent in various microchannel and/or micromixer setups and showcasing how these setups can be utilized individually or in combination, as well as how this technology allows the development of new advances in more efficient and controlled fabrication of core‐shell nanoformulations. Recent biological studies have achieved an effective, safe, and controlled delivery of otherwise unreliable encapsulants such as small interfering RNA (siRNA), plasmid DNA (pDNA), and cisplatin as a result of precisely tuned fabrication of nanocarriers, showing that this technology is paving the way for innovative strategies in cancer therapy nanofabrication, characterized by continuous production and high reproducibility. Finally, this review analyzes the technical, biological, and technological limitations that currently prevent this technology from becoming the standard.
Nanozymes for Treating Ocular Diseases
Authors: Wong Ka‐Ying , Wong Man‐Sau , Liu Juewen 
Published: May 2024

AbstractNanozymes, characterized by their nanoscale size and enzyme‐like catalytic activities, exhibit diverse therapeutic potentials, including anti‐oxidative, anti‐inflammatory, anti‐microbial, and anti‐angiogenic effects. These properties make them highly valuable in nanomedicine, particularly ocular therapy, bypassing the need for systemic delivery. Nanozymes show significant promise in tackling multi‐factored ocular diseases, particularly those influenced by oxidation and inflammation, like dry eye disease, and age‐related macular degeneration. Their small size, coupled with their ease of modification and integration into soft materials, facilitates the effective penetration of ocular barriers, thereby enabling targeted or prolonged therapy within the eye. This review is dedicated to exploring ocular diseases that are intricately linked to oxidation and inflammation, shedding light on the role of nanozymes in managing these conditions. Additionally, recent studies elucidating advanced applications of nanozymes in ocular therapeutics, along with their integration with soft materials for disease management, are discussed. Finally, this review outlines directions for future investigations aimed at bridging the gap between nanozyme research and clinical applications.
Inhibiting Residual Solvent Induced Side Reactions in Vinylidene Fluoride‐Based Polymer Electrolytes Enables Ultra‐Stable Solid‐State Lithium Metal Batteries
Authors: Zhang Dechao , Liu Yuxuan , Yang Shuo , Zhu Jiaxiong , Hong Hu , Li Shimei , Xiong Qi , Huang Zhaodong , Wang Shixun , Liu Jun , Zhi Chunyi 
Published: May 2024

AbstractResidual solvents in vinylidene fluoride (VDF)‐based solid polymer electrolytes (SPEs) have been recognized as responsible for their high ionic conductivity. However, side reactions by the residual solvents with the lithium (Li) metal induce poor stability, which has been long neglected. This study proposes a strategy to achieve a delicate equilibrium between ion conduction and electrode stability for VDF‐based SPEs. Specifically, 2,2,2‐trifluoro‐N,N‐dimethylacetamide (FDMA) is developed as the nonside reaction solvent for poly(vinylidene fluoride‐co‐hexafluoropropylene) (PVHF)‐based SPEs, achieving both high ionic conductivity and significantly improved electrochemical stability. The developed FDMA solvent fosters the formation of a stable solid electrolyte interphase (SEI) through interface reactions with Li metal, effectively mitigating side reactions and dendrite growth on the Li metal electrode. Consequently, the Li||Li symmetric cells and Li||LiFePO4 cells demonstrate excellent cycling performance, even under limited Li (20 µm thick) supply and high‐loading cathodes (>10 mg cm−2, capacity >1 mAh cm−2) conditions. The stable Li||LiCoO2 cells operation with a cutoff voltage of 4.48 V indicates the high‐voltage stability of the developed SPE. This study offers valuable insights into the development of advanced VDF‐based SPEs for enhanced lithium metal battery performance and longevity.
A self‐regulated phototheranostic nanosystem with single wavelength‐triggered energy switching and oxygen supply for multimodal synergistic therapy of bacterial biofilm infections
Authors: Wang Cheng , Lv Shuyi , Sun Zhencheng , Xiao Minghui , Fu Hao , Tian Liang , Zhao Xianhao , Shi Linqi , Zhu Chunlei 
Published: May 2024

AbstractThe exploration of antibiotic‐independent phototherapy strategies for the treatment of bacterial biofilm infections has gained significant attention. However, efficient eradication of bacterial biofilms remains a challenge. Herein, a self‐regulated phototheranostic nanosystem with single wavelength‐triggered photothermal therapy (PTT)/photodynamic therapy (PDT) transformation and oxygen supply for multimodal synergistic therapy of bacterial biofilm infections is presented. This approach combines a eutectic mixture of natural phase‐change materials (PCMs) and an aggregation‐induced emission (AIE) phototheranostic agent TPA‐ICN to form colloidally stable nanopartcicles (i.e. AIE@PCM NPs). The reversible solid−liquid phase transition of PCMs facilitates the adaptive regulation of the aggregation states of TPA‐ICN, enabling a switch between the energy dissipation pathways for enhanced PDT in solid PCMs or enhanced PTT in liquid PCMs. Additionally, oxygen‐carrying thermoresponsive nanoparticles are also introduced to alleviate the hypoxic microenvironment of biofilms by releasing oxygen upon heating by AIE@PCM NPs with enhanced PTT. The nanosystem exhibits outstanding therapeutic efficacy against bacterial biofilms both in vitro and in vivo, with an antibacterial efficiency of 99.99%. This study utilizes a self‐regulated theranostic nanoplatform with adaptive PTT/PDT transformation via the phase transition of PCMs and heat‐triggered oxygen release, holding great promise in the safe and efficient treatment of bacterial biofilm infections.
Adding injury to insult: Unfair treatment at work and occupational injury among hospital patient‐care workers
Authors: Sabbath Erika L. , Pan Yixin , McTernan Melissa L. , Peters Susan E. , Lovett Sharonda M. , Stelson Elisabeth A. , Wagner Gregory R. , Hopcia Karen , Boden Leslie I. 
Published: May 2024

AbstractBackgroundHospital patient‐care workers have high occupational injury rates. While physical hazards within hospital work environments are established determinants of injury, social exposures may also contribute. This study examined how reports of unfair treatment at work, a dimension of work‐related experiences of discrimination, were associated with injury among hospital‐based patient‐care workers.MethodsWe used data from the Boston Hospital Workers Health Study, a longitudinal cohort of nurses and nursing assistants at two Boston‐area hospitals. In 2018, we conducted a worker survey asking about three types of unfair treatment at work and occupational injuries during the past year. We used mixed‐effects logistic regression models to evaluate associations between specific types, total load, and high‐frequency exposure of unfair treatment with injury, adjusting for age, gender, race and ethnicity, job title, and unit type.ResultsAmong 1001 respondents, 21% reported being humiliated in front of others at work, 28% reported being watched more closely than other workers, and 47% reported having to work twice as hard as others for the same treatment. For each type of unfair treatment, we observed a monotonic relationship with occupational injury wherein increasing frequency of exposure was associated with increased odds of injury. We also observed monotonic relationships between total load and high‐frequency exposure to unfair treatment and odds of injury.ConclusionsWork‐related unfair treatment is associated with injury among hospital workers. Programs and policies that focus on preventing unfair treatment may lessen injury burden in hospital workers.
Golden lion tamarin metapopulation dynamics five years after heavy losses to yellow fever
Authors: Dietz James M. , Mickelberg Jennifer , Traylor‐Holzer Kathy , Martins Andréia F. , Souza Mateus N. , Hankerson Sarah J. 
Published: May 2024

AbstractThe golden lion tamarin (GLT) is an Endangered primate endemic to Brazil's lowland Atlantic Forest. After centuries of deforestation and capture for the pet trade, only a few hundred individuals survived, all in isolated forest fragments 85 km from Rio de Janeiro city. Intensive conservation actions, including reintroduction of zoo‐born tamarins, increased numbers to about 3700 in 2014. The most severe yellow fever epidemic/epizootic in Brazil in 80 years reduced two of the largest GLT populations by over 90%. Herein we report the results of a 2023 survey of GLTs designed to examine the dynamics of population recovery following yellow fever. Results indicate that populations hard hit by yellow fever are recovering due in part to immigration from adjacent forest fragments. No local extirpations were observed. About 4800 GLTs live in the survey area. This represents a 31% increase since the baseline survey completed in 2014. Two factors explain most of the increase: four large areas that had no GLTs or very low‐density populations in 2014 are now at moderate density (three areas) or low density (one area), explaining 71% of overall increase since 2014. Increase in forest area within our survey area may explain up to 16% of the increase in GLT numbers since 2014. Results of computer simulations suggest that strengthening forest connectivity will facilitate metapopulation resilience in the face of mortality factors such as yellow fever.
Effiziente enzymatische Synthese von Carbamaten in Wasser durch promiskuitive Esterasen/Acyltransferasen
Authors: Meinert Hannes , Oehlschläger Florian , Cziegler Clemens , Rockstroh Jan , Marzuoli Irene , Bisagni Serena , Lalk Michael , Bayer Thomas , Iding Hans , Bornscheuer Uwe T. 
Published: May 2024

AbstractDie Biokatalyse bietet einen attraktiven Ansatz, um synthetische Reaktionen in wässriger Lösung zu ermöglichen. Motiviert durch die Entdeckung der vielseitigen Aminolyseaktivität von Esterasen haben wir die Esterase aus Pyrobaculum calidifontis VA1 (PestE) für die Synthese von Carbamaten aus verschiedenen aliphatischen, aromatischen und arylaliphatischen Aminen sowie einer Reihe von Carbonaten wie Dimethyl‐, Dibenzyl‐ oder Diallylcarbonat genutzt. So konnten Anilin‐ und Benzylaminderivate, aliphatische und sogar sekundäre Amine effizient in die entsprechenden Benzyloxycarbonyl (Cbz)‐ oder Allyloxycarbonyl (Alloc)‐geschützten Produkte in wässriger Lösung, mit (isolierten) Ausbeuten von bis zu 99 % umgesetzt werden.
Aromatic linker variations in novel dopamine D2 and D3 receptor ligands
Authors: Di Biase Cristian , Leitzbach Luisa , Frank Annika , Zivkovic Aleksandra , Stark Holger 
Published: May 2024

AbstractDopamine D2‐like receptors, especially D2 and D3 receptor subtypes, are important targets of antipsychotic agents. Many of these antipsychotics share an aliphatic linker element between a protonable amine group and an acyl‐like moiety. Here, we have modified this aliphatic linker into phenylmethyl and phenylethyl linkers substituted in different positions. The design, synthesis, and in vitro evaluation of 18 dopamine D2 and D3 receptor ligands were performed in this study. Using a radioligand displacement assay, all ligands were found to have modest nanomolar affinity to D2R and D3R. N‐(4‐{2‐[4‐(2‐Methoxyphenyl)piperazin‐1‐yl]ethyl}phenyl)acetamide (6c) demonstrates the highest D3R and D2R affinity values (pKi values of 7.83 [D2R] and 8.04 [D3R]), featuring a slight preference to D3R. This derivative can be taken as a reference structure for the development of a new class of D2R and D3R ligands.
Copper Catalyzed Borylation of Alkynes: An Experimental Mechanistic Study
Authors: Rutz Philipp M. , Kleeberg Christian 
Published: May 2024

AbstractThe copper catalyzed hydroboration of alkynes with B2pin2 was studied by in detail studies of individual relevant steps along the catalytic pathway. A number of reaction steps were retraced by in situ NMR spectroscopy as well as central intermediates and side‐products were isolated and comprehensively characterized. A copper boryl complex is central to the catalytic process by inserting the terminal alkyne substrate into the B−Cu bond. The selectivity of this step – depending on the NHC auxiliary ligand – determines the α/β selectivity observed in the product. The latter complex is protonated by the auxiliary alcohol reagent resulting in hydroboration product formation and formation of a Cu alkoxido complex. Reaction of the latter with B2pin2 results in the regeneration of the central copper boryl complex. This alcoholysis step depends on the acidity of the alcohol, in particular on the relative acidity of the alcohol vs. the alkyne substrate. A number of side reactions leading to the hydrogenation product of the alkyne substrate and a bis hydroborated product were identified and studied in some detail. It is concluded that the performance of a particular catalytic system depends crucially on the relative acidities of the reagents and generalizations may be difficult.
Hexagonal Halide Perovskite Cs2LiInCl6: Cation Ordering, Face‐Shared Octahedral Trimers and Mn2+ Luminescence
Authors: Wang Bingqi , Liu Pan , Fernández‐Carrión Alberto J. , Fu Hui , Zhu XiuHui , Ming Xing , You Weixiong , Xiao Zongliang , Tang Mingxue , Lei Xiuyun , Yin Congling , Kuang Xiaojun 
Published: May 2024

AbstractThe In‐based double perovskite halides have been widely studied for promising optical‐electric applications. The halide hexagonal perovskite Cs2LiInCl6 was isolated using solid‐state reactions and investigated using X‐ray diffraction and solid‐state NMR spectra. The material adopts a 12‐layered hexagonal structure (12R) consisting of layered cationic orders driven by the cationic charge difference and has Li+ cations in the terminal site and In3+ in the central site of face‐shared octahedron trimers. Such a cationic ordering pattern is stabilized by electrostatic repulsions between the next‐nearest neighboring cations in the trimers. The LiCl6 octahedron displays large distortion and is confirmed by 7Li SS NMR in the Cs2LiInCl6. The Cs2LiInCl6 material has a direct bandgap of ~4.98 eV. The Cs2LiInCl6: Mn2+ displays redshift luminescence (centered at ~610–622 nm) from the substituted Mn2+ emission in octahedron with larger PLQY (17.8 %–48 %) compared with that of Cs2NaInCl6: Mn2+. The Mn‐doped materials show luminescent concentration quenching and thermal quenching. The composition Cs2Li0.99In0.99Mn0.02Cl6 exhibits the highest PL intensity, a maximum PLQY of 48 %, and high luminescent retention rate of ~86 % below 400 K and is suitable for application for pc‐LED. These findings contribute to our understanding of the chloride perovskites and hold potential for widespread optical applications.