bluuebunny/crossref_metadata_2025_split huggingface dataset:
Brain Delivery of Protein Therapeutics by Cell Matrix‐Inspired Biomimetic Nanocarrier
Authors: Huang Jialin , Fu Yuli , Wang Antian , shi Kexing , Peng Yidong , Yi Yao , Yu Renhe , Gao Jinchao , Feng Junfeng , Jiang Gan , Song Qingxiang , Jiang Jiyao , Chen Hongzhuan , Gao Xiaoling 
Published: May 2024

AbstractProtein therapeutics are anticipated to offer significant treatment options for central nervous system (CNS) diseases. However, the majority of proteins are unable to traverse the blood–brain barrier (BBB) and reach their CNS target sites. Inspired by the natural environment of active proteins, the cell matrix components hyaluronic acid (HA) and protamine (PRTM) are used to self‐assemble with proteins to form a protein‐loaded biomimetic core and then incorporated into ApoE3‐reconstituted high‐density lipoprotein (rHDL) to form a protein‐loaded biomimetic nanocarrier (Protein‐HA‐PRTM‐rHDL). This cell matrix‐inspired biomimetic nanocarrier facilitates the penetration of protein therapeutics across the BBB and enables their access to intracellular target sites. Specifically, CAT‐HA‐PRTM‐rHDL facilitates rapid intracellular delivery and release of catalase (CAT) via macropinocytosis‐activated membrane fusion, resulting in improved spatial learning and memory in traumatic brain injury (TBI) model mice (significantly reduces the latency of TBI mice and doubles the number of crossing platforms), and enhances motor function and prolongs survival in amyotrophic lateral sclerosis (ALS) model mice (extended the median survival of ALS mice by more than 10 days). Collectively, this cell matrix‐inspired nanoplatform enables the efficient CNS delivery of protein therapeutics and provides a novel approach for the treatment of CNS diseases.
Design Approaches and Electromechanical Modeling of Conformable Piezoelectric‐Based Ultrasound Systems
Authors: Amiri Nikta , Shah Aastha , Bhayadia Amit Kumar , Yu Chia‐Chen , Karami M. Amin , Dagdeviren Canan 
Published: May 2024

AbstractPainless, needleless delivery of drugs through the skin can be realized through aphenomenon called sonophoresis by applying an ultrasound field to the biological tissue. Development of wearable embodiments of such systems demands comprehensive characterization of both the physical mechanism of sonophoresisas well as wearability parameters. Here, we present a framework for analyzing disk‐type piezoelectric transducers in a polymeric substrate to create acoustic cavitation in a fluid coupling medium for sonophoresis applications. The device design and operating parameters such as the working frequency, applied voltage range, acoustic pressure distribution, and transducer spacing were determine dusing a finite element methods (FEM),and verified with experimental measurements. The influence of the surrounding water and tank reflections on the acoustic pressure field, and the interaction between the elements in the array structure were also studied.Finally, the impact of skin and the substrate geometry on the acoustic pressure fields was characterized to simulate the invivo use‐case of the system. These analytical models can be used to guide critical parameters for device design such as the separation distance of the piezoelectric transducer from the skin boundary. We envision that this tool boxwill support rapid design iteration for realization of wearable ultrasound systems.
Mitochondria Energy Metabolism Depression as Novel Adjuvant to Sensitize Radiotherapy and Inhibit Radiation Induced‐Pulmonary Fibrosis
Authors: Zhou Zaigang , Jiang Xin , Yi Lei , Li Cheng , Wang Haoxiang , Xiong Wei , Li Zhipeng , Shen Jianliang 
Published: May 2024

AbstractCurrently, the typical combination therapy of programmed death ligand‐1 (PD‐L1) antibodies with radiotherapy (RT) still exhibits impaired immunogenic antitumor response in clinical due to lessened DNA damage and acquired immune tolerance via the upregulation of some other immune checkpoint inhibitors. Apart from this, such combination therapy may raise the occurrence rate of radiation‐induced lung fibrosis (RIPF) due to enhanced systemic inflammation, leading to the ultimate death of cancer patients (average survival time of about 3 years). Therefore, it is newly revealed that mitochondria energy metabolism regulation can be used as a novel effective PD‐L1 and transforming growth factor‐β (TGF‐β) dual‐downregulation method. Following this, IR‐TAM is prepared by conjugating mitochondria‐targeted heptamethine cyanine dye IR‐68 with oxidative phosphorylation (OXPHOS) inhibitor Tamoxifen (TAM), which then self‐assembled with albumin (Alb) to form IR‐TAM@Alb nanoparticles. By doing this, tumor‐targeting IR‐TAM@Alb nanoparticle effectively reversed tumor hypoxia and depressed PD‐L1 and TGF‐β expression to sensitize RT. Meanwhile, due to the capacity of heptamethine cyanine dye in targeting RIPF and the function of TAM in depressing TGF‐β, IR‐TAM@Alb also ameliorated fibrosis development induced by RT.
Expanded prenatal phenotype of ALG12‐associated congenital disorder of glycosylation including bilateral multicystic kidneys
Authors: Shanmugasundaram Manjushree , Wang Amanda , Morand Megan , Bixler Colin , Jain Sangeeta , Ray Joseph 
Published: May 2024

AbstractCongenital disorders of glycosylation (CDG) are a group of rare autosomal recessive genetic disorders caused by pathogenic variants in genes coding for N‐glycosylated glycoproteins, which play a role in folding, degrading, and transport of glycoproteins in their pathway. ALG12‐CDG specifically is caused by biallelic pathogenic variants in ALG12. Currently reported features of ALG12‐CDG include: developmental delay, hypotonia, failure to thrive and/or short stature, brain anomalies, recurrent infections, hypogammaglobulinemia, coagulation abnormalities, and genitourinary abnormalities. In addition, skeletal abnormalities resembling a skeletal dysplasia including shortened long bones and talipes equinovarus have been seen in more severe neonatal presentation of this disorder. We report on a case expanding the phenotype of ALG12‐CDG to include bilateral, multicystic kidneys in a neonatal demise identified with homozygous pathogenic variants in the ALG12 gene at c.1001del (p.N334Tfs*15) through clinical trio exome sequencing.
Orbital decompression surgery among Medicare beneficiaries in the post‐teprotumumab era
Authors: Bhat Akash M. , Soler Zachary M. , Schlosser Rodney J. , Metson Ralph B. , Rathi Vinay K. 
Published: May 2024

Key points
Utilization of orbital decompressions (ODS) increased (CAGR: +3.2%) from 2000 to 2019.
FDA approved teprotumumab in January 2020; ODS utilization decreased (CAGR: −14.9%) from 2019 to 2022.
In 2022, total spending was substantially higher for teprotumumab ($325 million) than surgery ($580,000).
Antidepressant exposure and long‐term dementia risk in a nationwide retrospective study on US veterans with midlife major depressive disorder
Authors: Ramos‐Cejudo Jaime , Corrigan June K. , Zheng Chunlei , Swinnerton Kaitlin N. , Jacobson Sean R. , La Jennifer , Betensky Rebecca A. , Osorio Ricardo S. , Madanes Sharon , Pomara Nunzio , Iosifescu Dan , Brophy Mary , Do Nhan V. , Fillmore Nathanael R. 
Published: May 2024

AbstractINTRODUCTIONThe use of antidepressants in major depressive disorder (MDD) has been reported to influence long‐term risk of Alzheimer's disease (AD) and AD‐related dementias (AD/ADRD), but studies are conflicting.METHODSWe used inverse probability weighted (IPW) Cox models with time‐varying covariates in a retrospective cohort study among midlife veterans with MDD within the US Veterans Affairs healthcare system from January 1, 2000 to June 1, 2022.RESULTSA total of 35,200 patients with MDD were identified. No associations were seen regarding the effect of being exposed to any antidepressant versus no exposure on AD/ADRD risk (events = 1,056, hazard ratio = 0.94, 95% confidence interval: 0.81 to 1.09) or the exposure to specific antidepressant classes versus no exposure. A risk reduction was observed for female patients in a stratified analysis; however, the number of cases was small.DISCUSSIONOur study suggests that antidepressant exposure has no effect on AD/ADRD risk. The association in female patients should be interpreted with caution and requires further attention.Highlights
We studied whether antidepressant use was associated with future dementia risk.
We specifically focused on patients after their first‐ever diagnosis of depression.
We used IPW Cox models with time‐varying covariates and a large observation window.
Our study did not identify an effect of antidepressant use on dementia risk.
A risk reduction was observed in female patients, but the number of cases was small.
Adaptive Response to Solvation in Flexible Molecules: Oligo Hydrates of 4‐Hydroxy‐2‐butanone
Authors: Li Meng , Li Wenqin , Pérez Cristóbal , Lesarri Alberto , Grabow Jens‐Uwe 
Published: May 2024

AbstractStructural changes induced by water play a pivotal role in chemistry and biology but remain challenging to predict, measure, and control at molecular level. Here we explore size‐governed gas‐phase water aggregation in the flexible molecule 4‐hydroxy‐2‐butanone, modeling the conformational adaptability of flexible substrates to host water scaffolds and the preference for sequential droplet growth. The experiment was conducted using broadband rotational spectroscopy, rationalized with quantum chemical calculations. Two different isomers were observed experimentally from the di‐ to the pentahydrates (4‐hydroxy‐2‐butanone‐(H2O)n=2–5), including the 18O isotopologues for the di‐ and trihydrates. Interestingly, to accommodate water molecules effectively, the heavy atom skeleton of 4‐hydroxy‐2‐butanone reshapes in every observed isomer and does not correspond to the stable conformer of the free monomer. All solvates initiate from the alcohol group (proton donor) but retain the carbonyl group as secondary binding point. The water scaffolds closely resemble those found in the pure water clusters, balancing between the capability of 4‐hydroxy‐2‐butanone for steering the orientation and position of the water molecules and the ability of water to modulate the monomer's conformation. The present work thus provides an accurate molecular description on how torsionally flexible molecules dynamically adapt to water along progressing solvation.
Enzyme‐Activatable Near‐Infrared Hemicyanines as Modular Scaffolds for in vivo Photodynamic Therapy
Authors: Cheng Zhiming , Benson Sam , Mendive‐Tapia Lorena , Nestoros Eleni , Lochenie Charles , Seah Deborah , Chang Kai Yee , Feng Yi , Vendrell Marc 
Published: May 2024

AbstractPhotodynamic therapy is an anti‐cancer treatment that requires illumination of photosensitizers to induce local cell death. Current near‐infrared organic photosensitizers are built from large and non‐modular structures that cannot be tuned to improve safety and minimize off‐target toxicity. This work describes a novel chemical platform to generate enzyme‐activatable near‐infrared photosensitizers. We optimized the Se‐bridged hemicyanine scaffold to include caging groups and biocompatible moieties, and generated cathepsin‐triggered photosensitizers for effective ablation of human glioblastoma cells. Furthermore, we demonstrated that enzyme‐activatable Se‐bridged hemicyanines are effective photosensitizers for the safe ablation of microtumors in vivo, creating new avenues in the chemical design of targeted anti‐cancer photodynamic therapy agents.
Bis‐Ortho‐Donor‐Modification of Boracyclic π‐Electron Systems beyond Steric Protection to Produce Thermally Activated Delayed Fluorescence Materials
Authors: Narita Hiroki , Min Hyukgi , Kubo Nanami , Hattori Izumi , Yasuda Takuma , Yamaguchi Shigehiro 
Published: May 2024

AbstractPolycyclic π‐conjugated compounds that contain tricoordinate boron atoms at their periphery represent an attractive class of materials with electron‐accepting character. Their molecular design generally requires the introduction of a bulky aryl group onto the boron atom, where it provides predominantly kinetic stabilization. The addition of extra functionality to the aryl group on the boron atom can be expected to further expand the potential utility of this class of materials. Herein, we report the synthesis of a series of boracyclic π‐conjugated molecules with firm ortho B⋅⋅⋅N nonbonding interactions by introducing N‐containing electron‐donors at the ortho‐positions of the aryl group on the boron atom. X‐ray crystallographic analysis revealed that the combination of a planar boracyclic π‐skeleton with only sp2 carbons and a strong electron‐donating phenothiazine moiety results in a particularly short B⋅⋅⋅N distance. Theoretical study provided insights into the inherent nature of the B⋅⋅⋅N interaction. Owing to their donor–acceptor (D−A) structures, these molecules exhibit substantially red‐shifted fluorescence in solution, albeit that the fluorescence quantum yields (ΦF) are low. In contrast, when incorporated into films, these compounds exhibit thermally activated delayed fluorescence (TADF) with improved ΦF values. Organic light‐emitting diodes (OLEDs) fabricated using the ortho‐donor‐substituted derivatives exhibit orange‐red electroluminescence.
Impact of marine debris on coral reef ecosystem of Palk Bay, Indian Ocean
Authors: Pillai Ranith Rajamohanan , Lakshmanan Senthilnathan , Mayakrishnan Machendiranathan , George Grinson , Menon Nandini 
Published: May 2024

Abstract

Coral reef ecosystems are highly sensitive to pollution from marine debris, especially if the regions are noted for tourism and fishing. Palk Bay on the south east coast of India is a famous tourist and fishing region, where the marine debris accumulation poses a great threat to the coastal ecosystem.
In this study during 2018–2020, the marine debris distribution and their interactions with coral reefs of Palk Bay were monitored from five stations. Derelict fishing gears (DFGs), including ropes (51 ± 2%) and fishing lines (43 ± 2.5%), were the dominant debris forms recorded.
Among the reef‐forming corals, Acropora sp. colonies experienced maximum physical injury and mortality from DFG entanglement. Plastic materials and anchors caused considerable physical damage and tissue loss in Porites sp, without any mortality.
Manual debris removal as a potential debris management method was assessed by regularly removing the accumulated debris from the test reef locations of all five stations, whereas the control reef locations were left undisturbed. Test reef locations showed a significant increase in live coral cover and coral recruit density in 2020, against that in 2018, compared with the control locations. Continuous accumulation and interaction of marine debris with the coral colonies of control reef locations resulted in significant reduction of live coral cover and coral recruit density at the control reef locations.
This study illustrates the impact of unsustainable fishing and other anthropogenic activities such as tourism and waste disposal on coral reef ecosystems like Palk Bay. The findings of this study demonstrates that manual removal of debris is an important strategy for marine debris management in coral reef ecosystem. Considering the importance of coral reefs in the livelihood of the coastal communities, it is important to tackle the marine debris issue through regular debris removal with stakeholder participation, awareness campaigns and strict legal and management measures.
Trajectory tracking of a wheeled mobile robot based on the predefined‐time sliding mode control scheme
Authors: Cong Shaoheng , Wang Zhonghua , Li Meng , Jiang Yutian , Zhang Ruwei 
Published: May 2024

AbstractIn this paper, a double‐loop control method is proposed to improve the trajectory tracking performance of a wheeled mobile robot (WMR) with slippage properties and external disturbances. Considering the strong robustness and the ability to enable the system to converge in a short time, the predefined‐time sliding mode control (PTSMC) strategy is applied to the design of a double‐loop controller. Furthermore, a nonlinear disturbance observer (NDO) is adopted to comply with the feedforward compensation of the external disturbances. In turn, the controller only needs to deal with the internal disturbance of the system under the premise of using the NDO, thereby reducing the burden of the sliding mode controller. Based on Lyapunov methods, the stability of the double‐loop controller and the NDO is analyzed. Finally, the feasibility of the double‐loop control strategy is proven by simulations of the WMR operating along circular, sin‐shaped, and eight‐shaped roads.
Integrating eco‐labeling and green advertising in achieving Sustainable Development Goal 12
Authors: Abbas Shahbaz , Munir Hania , Ahmad Yasir 
Published: May 2024

AbstractSustainable Development Goal 12 (SDG‐12), that is the responsible consumption and production, is aimed to encourage producers and consumers to consider sustainable development while producing and consuming products. However, it is imperative to estimate the social achievement of SDG‐12 objective at the consumption end. Eco‐labeling and green advertising are the common business marketing strategies employed to inform and influence consumers to make environmentally conscious choices. This study explores the integrated factors of these strategies to influence consumer perceptions, attitudes, and purchase intentions toward environmentally friendly products in a developing country. The data from 327 respondents using a survey questionnaire are analyzed using structural model equation to measure the hypothetical relationship of eco‐labeling and green advertising in achieving SDG‐12. The results indicate that perceived effectiveness, environmental awareness, green trust, and perceived information quality as instrumental factors directly contributing to consumers' intentions to engage in green purchases eventually ensuring SDG‐12 targets, while price sensitivity is the major challenge that is required to be addressed.
Dual‐functional and polydopamine‐coated vanadium disulfide for “fast‐charging” lithium‐ion batteries
Authors: Wang Lu , Dang Hao , He Tianqi , Liu Rui , Wang Rui , Ran Fen 
Published: May 2024

AbstractAs a typical representative of vanadium‐based sulfides, vanadium disulfide has attracted the attention of researchers ascribed to its high theoretical capacity and unique crystal structure. However, overcoming its structural collapse while achieving dual functionalization that serves as both active material and binder remains challenging. This study designs a dopamine‐coating vanadium disulfide core‐shell structure through the synergistic effect of V‐O bonds and hydrogen bonds between vanadium disulfide and dopamine, which is further employed as a dual‐function electrode material. The polydopamine‐coated vanadium disulfide without binder exhibits specific capacity of 682.03 mAh g−1, and the Coulombic efficiency of 99.78% at a current density of 200 mA g−1 after 400 cycles. More importantly, at a larger current density of 1000 mA g−1, the specific capacity is 385.44 mAh g−1 after 1500 cycles. After 3150 cycles, the specific capacity is 200.32 mAh g−1 at 2000 mA g−1. Electrochemical kinetics analysis displays that the polydopamine‐coated vanadium disulfide without binder exhibits fast ion‐diffusion kinetics, with the order of magnitude of ion‐diffusion coefficients ranging from 10−11 to 10−12. This kind of material has the potential to be a significantly promising electrode material for “fast‐charging” lithium‐ion batteries.
Therapeutic potential and impact of nanoengineered patient‐derived mesenchymal stem cells in a murine resection and recurrence model of human glioblastoma
Authors: Al‐Kharboosh Rawan , Bechtle Alex , Tzeng Stephany Y. , Zheng Jiaying , Mondal Sujan Kumar , Wilson David R. , Perez‐Vega Carlos , Green Jordan J. , Quiñones‐Hinojosa Alfredo 
Published: May 2024

AbstractConfounding results of engineered mesenchymal stem cells (MSCs) used as cellular vehicles has plagued technologies whereby success or failure of novel approaches may be dismissed or inaccurately ascribed solely to the biotechnology platform rather than suitability of the human donor. Polymeric materials were screened for non‐viral engineering of MSCs from multiple human donors to deliver bone morphogenic protein‐4 (BMP4), a protein previously investigated in clinical trials for glioblastoma (GBM) to combat a subpopulation of highly invasive and tumorigenic clones. A “smart technology” that target the migratory and stem‐like nature of GBM will require: (1) a cellular vehicle (MSC) which can scavenge and target residual cells left behind after surgical debulking and deliver; (2) anti‐glioma cargo (BMP4). Multiple MSC donors are safely engineered, though varied in susceptibility to accept BMP4 due to intrinsic characteristics revealed by their molecular signatures. Efficiency is compared via secretion, downstream signaling, differentiation, and anti‐proliferative properties across all donors. In a clinically relevant resection and recurrence model of patient‐derived human GBM, we demonstrate that nanoengineered MSCs are not “donor agnostic” and efficacy is influenced by the inherent suitability of the MSC to the cargo. Therefore, donor profiles hold greater influence in determining downstream outcomes than the technical capabilities of the engineering technology.
Histone deacetylase 6 as a novel promising target to treat cardiovascular disease
Authors: Wu Ya‐Xi , Li Bing‐Qian , Yu Xiao‐Qian , Liu Yu‐Lin , Chui Rui‐Hao , Sun Kai , Geng Dian‐Guang , Ma Li‐Ying 
Published: May 2024

AbstractHistone deacetylase 6 (HDAC6) belongs to a class of epigenetic targets that have been found to be a key protein in the association between tumors and cardiovascular disease. Recent studies have focused on the crucial role of HDAC6 in regulating cardiovascular diseases such as atherosclerosis, myocardial infarction, myocardial hypertrophy, myocardial fibrosis, hypertension, pulmonary hypertension, and arrhythmia. Here, we review the association between HDAC6 and cardiovascular disease, the research progress of HDAC6 inhibitors in the treatment of cardiovascular disease, and discuss the feasibility of combining HDAC6 inhibitors with other therapeutic agents to treat cardiovascular disease.