bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Scanning Electron Micrographical Study of Root Surfaces and Subgingival Bacteria After Hand and Ultrasonic Instrumentation
Authors: Garnick Jerry J. , Dent J. 
Published: March 2012

The effects of hand and ultrasonic instrumentation on root surface topography and subgingival plaque were studied. One approximal subgingival root surface on each of two single rooted teeth of six patients was root planed. The opposing proximal surfaces were not treated and served as controls. On each patient, the two test surfaces were randomly treated by hand or ultrasonic instrumentation (Cavitron) until clinically smooth. The teeth were extracted, divided into mesial and distal sides, and processed for scanning electron microscopy (SEM). The observations were restricted to an area 2 mm by 3 mm just coronal to the plaque‐free zone. The root surfaces were scanned by SEM, both at low (× 100) and at higher magnifications (× 5000). At low power, a photomontage was produced of the surface area of the test teeth.At low magnifications (× 100, × 500), the topography resulting from hand instrumentation appeared smooth with parallel scratches compared to scaly but flat surfaces with occasional deep gouges with the ultrasonic method. At high magnifications (× 5000), tooth surfaces were similar in topography when instrumented by either hand or ultrasonic methods. Root surfaces were covered in some areas by a fibrillar‐like membrane that resembled fibrin. Individual bacteria were found on the surfaces of this material. On other areas not covered by this membrane, bacterial plaque was only observed when tooth surfaces had not been contacted by either hand or ultrasonic instrumentation.
Rheological behavior of chlorosulfonated polyethylene composites: Effect of filler and plasticizer
Authors: Nanda M. , Tripathy D. K. 
Published: March 2012

AbstractThe rheological properties of chlorosulfonated polyethylene (CSM) loaded with conductive carbon black filler were measured using capillary rheometer at three different temperatures (110, 120, and 130°C) and four different shear rates (12.26, 24.52, 61.3, and 122.6 s−1). The effect of filler and plasticizer [dioctyl phthalate (DOP)] loading on melt flow properties of CSM was also studied. The viscosities of all samples decrease with shear rate indicating their pseudoplastic or shear thinning nature. The higher shear viscosity is observed for the CSM loaded with higher filler content, which may be due to inhibition of the polymer chain motion by the filler particles. With increasing filler loading the extrudate swell clearly decreased, which is attributed to the limitation of the elastic recovery of the polymer chains by filler particulates. Further, the reduction in die‐swell ratio with increase in plasticizer loading indicates a reduction in melt elasticity compared with the composite containing no DOP. The dependence of shear viscosity on temperature obeyed the Arrhenius–Eyring expression, and the activation energy (Eγ) decreased with increasing shear rate. Extrudate swell is a non‐linear function of shear rate. © 2012 Wiley Periodicals, Inc. J Appl Polym Sci, 2012
ChemInform Abstract: Ru—OSO Coordination Photogenerated at 100 K in Tetraammineaqua(sulfur dioxide)ruthenium(II) (.+‐.)‐Camphorsulfonate.
Authors: Phillips Anthony E. , Cole Jacqueline M. , d'Almeida Thierry , Low Kian Sing 
Published: March 2012

AbstractThe photoinduced metastable O‐bound coordination mode in RuSO2 complexes, previously observed only at 13 K, is found to exists at 100 K in the title compound (RuC20H44O11N4S3, monoclinic space group C2/c, Z = 8; single crystal XRD).
ChemInform Abstract: Ba3Ga3N5 — A Novel Host Lattice for Eu2+‐Doped Luminescent Materials with Unexpected Nitridogallate Substructure.
Authors: Hintze Frauke , Hummel Franziska , Schmidt Peter J. , Wiechert Detlef , Schnick Wolfgang 
Published: March 2012

AbstractSingle crystals of Ba3Ga3N5 are prepared from a mixture of Ba, Sr, Ga, Mg, and NaN3 in a sodium flux (Ta ampule, 760 °C, 48 h).
ChemInform Abstract: Solution‐Based Synthesis and Characterization of Lithium‐Ion Conducting Phosphate Ceramics for Lithium Metal Batteries.
Authors: Key Baris , Schroeder David J. , Ingram Brian J. , Vaughey John T. 
Published: March 2012

AbstractLithium ion conducting Li1.3Al0.3Ti1.7(PO4)3 powder for us as solid electrolyte in lithium metal batteries is synthesized by evaporation of an aqueous solution containing H2[TiO(C2O4)2], Al(NO3)3, (NH4)2HPO4, and LiNO3, followed by annealing at temperatures as low as 650 °C (12 h).
ChemInform Abstract: Synthesis and Characterization of (H2dab) 2Cu8Ge4S14·2H2 O: An Expanded Framework Based on Icosahedral Cu8S12 Cluster.
Authors: Zhang Ren‐Chun , Zhang Chi , Ji Shou‐Hua , Ji Min , An Yong‐Lin 
Published: March 2012

AbstractThe new title compound (dab: 1,4‐diaminobutane) is solvothermally synthesized from a mixture of Cu, GeO2, S, and dab in a 1:1 mixture of MeOH and H2O (autoclave, 165 °C, 7 d, 62% yield).
ChemInform Abstract: NHC‐Carbene Cyclopentadienyl Iron Based Catalyst for a General and Efficient Hydrosilylation of Imines.
Authors: Misal Castro Luis C. , Sortais Jean‐Baptiste , Darcel Christophe 
Published: March 2012

AbstractAt general catalytic system for the efficient hydrosilylation of both aldimines and ketimines using a well‐defined iron complex as pre‐catalyst is developed which gives access to various amines (after hydrolysis).
ChemInform Abstract: A Newly‐Designed PE‐Supported Arsine for Efficient and Practical Catalytic Wittig Olefination.
Authors: Wang Peng , Liu Chun‐Rong , Sun Xiu‐Li , Chen Shuai‐Shuai , Li Jun‐Fang , Xie Zuowei , Tang Yong 
Published: March 2012

AbstractThe arsine efficiently catalyzes Wittig‐type olefinations of even inactive ketones, providing easy access to di‐, tri‐, and tetra‐substituted alkenes in high yields and with excellent stereoselectivities.
ChemInform Abstract: Copper‐Catalyzed Oxidative C—O Coupling by Direct C—H Bond Activation of Formamides: Synthesis of Enol Carbamates and 2‐Carbonyl‐Substituted Phenol Carbamates.
Authors: Kumar G. Sathish , Maheswari C. Uma , Kumar R. Arun , Kantam M. Lakshmi , Reddy K. Rajender 
Published: March 2012

AbstractA novel convenient copper‐catalyzed C—O bond coupling of formamides with β‐dicarbonyl compounds is presented, affording carbamates (III), (V) and (VIII) in moderate to good yields as single stereoisomers via a phosgene‐free pathway.
ChemInform Abstract: Palladium‐Catalyzed Desulfitative Cyanation of Arenesulfonyl Chlorides and Sodium Sulfinates.
Authors: Chen Jianbin , Sun Yang , Liu Bin , Liu Dongfang , Cheng Jiang 
Published: March 2012

AbstractThe title reaction, affording aromatic nitriles under mild conditions, shows wide functional group tolerance.
ChemInform Abstract: Synthesis of 2′,4‐Diarylbenzophenones Through Site‐Selective Suzuki—Miyaura Reactions of Bis(triflates) of 2′,4‐Dihydroxybenzophenones.
Authors: Nawaz Muhammad , Ullah Ihsan , Abid Obaid‐Ur‐Rahman , Villinger Alexander , Langer Peter 
Published: March 2012

AbstractThe reaction of bis(triflate) (I) with various arylboronic acids is used for the preparation of mino‐ or (symmetrical and unsymmetrical) bis‐arylated products.
ChemInform Abstract: Synthesis of an Antitumoral Diarylheptanoid Containing 1,3‐Diol Functionality.
Authors: Zhang Shaomin , Wu Yikang 
Published: March 2012

AbstractTitle compound (VIII) is synthesized starting from chiral epoxide (I) via ring opening and coupling reaction with the carbanion of dithiane (II), oxidative cleavage of key intermediate (IV) followed by treatment of (V) with Wittig—Horner reagent (VI) as the key steps.
ChemInform Abstract: Pd‐Catalyzed Cyclization Reaction: A Convenient Domino Process for Synthesis of α‐Carbonyl Furan Derivatives.
Authors: Cao Hua , Jiang Huan‐Feng , Huang Hua‐Wen , Zhao Jin‐Wu 
Published: March 2012

AbstractA novel two‐step one‐pot protocol for the preparation of α‐carbonyl compounds (III) from 1,3‐dicarbonyl compounds (I) and propargyl alcohols (II) is described.
ChemInform Abstract: Palladium‐Catalyzed Intramolecular Aminofluorination of Styrenes.
Authors: Xu Tao , Qiu Shuifa , Liu Guosheng 
Published: March 2012

Abstract2‐Aryltetrahydropyrroles are efficiently synthesized via a novel intramolecular oxidative aminofluorination of styrenes.
ChemInform Abstract: Carbon Monoxide‐Free One‐Step Synthesis of Isoindole‐1,3‐diones by Cycloaminocarbonylation of o‐Haloarenes Using Formamides.
Authors: Sawant Dinesh N. , Wagh Vogesh S. , Bhatte Kushal D. , Bhanage Bhalchandra M. 
Published: March 2012

AbstractThe reactions proceeds in the absence of CO and any solvent.
ChemInform Abstract: Palladium(II)‐Catalyzed One‐Pot Syntheses of 9‐(Pyridin‐2‐yl)‐9H‐carbazoles Through a Tandem C—H Activation/C—X (X: C or N) Formation Process.
Authors: Chu Jean‐Ho , Lin Pi‐Shan , Lee Ya‐Ming , Shen Wei‐Ting , Wu Ming‐Jung 
Published: March 2012

AbstractThe reaction of various N‐phenylpyridin‐2‐amines and potassium aryltrifluoroborates affords mostly mixtures of the major 9‐pyridyl‐carbazoles and arylated amines.
ChemInform Abstract: Modification of Biologically Active Amides and Amines with Fluoro‐Containing Heterocycles. Part 5. Fluoro‐Containing Heterocyclic Derivatives of 2‐Amino‐1,3,4‐thiadiazoles.
Authors: Sokolov V. B. , Aksinenko A. Yu. , Epishina T. A. , Goreva T. V. , Martynov I. V. 
Published: March 2012

AbstractImines, generated in situ from aminothiadiazoles (I) and methyl trifluoropyruvate (II) in the presence of the dehydrating system pyridine/thionyl chloride, undergo cyclocondensation with 1,3‐C,N‐ and 1,3‐N,N‐binucleophiles such as N‐substituted ureas (III), aminocrotononitrile (V), N‐substituted aminouracil (VIIa) and aminothiouracil (VIId), N‐substituted aminocyclohexenones (IX), and benzylbenzamidine (XI).
ChemInform Abstract: Synthesis of Nanoparticles Silica Supported Sulfuric Acid (NPs SiO2—H2SO4): A Solid Phase Acidic Catalyst for One‐Pot Synthesis of 4H‐Chromene Derivatives.
Authors: Sadeghi Bahareh , Hassanabadi Alireza , Bidaki Somayeh 
Published: March 2012

AbstractThe title acid is applied as efficient catalyst for the three‐component one‐pot synthesis of 4H‐chromene derivatives.
ChemInform Abstract: A Facile N‐Monoalkylation of Aminopyridines.
Authors: Tian Zhongzhen , Li Dongmei , Jiang Zhaoxing , Li Zhong 
Published: March 2012

AbstractThe N‐monoalkylation of 2‐ or 3‐aminopyridines by a carboxylic acid in the presence of sodium borohydride affords the corresponding alkylaminopyridines (III) under mild conditions and in good yields.
ChemInform Abstract: 4‐Hydroxy‐2‐quinolones. Part 197. The Search for Novel Diuretics Amongst Halo‐Substituted 6‐Hydroxy‐2‐methyl‐4‐oxo‐1,2‐dihydro‐4H‐pyrrolo [3,2‐1‐ij]quinoline‐5‐carboxylic Acid Anilides.
Authors: Ukrainets I. V. , Golik N. Yu. , Shemchuk A. L. , Naboka O. I. , Voronina Yu. V. , Turov A. V. 
Published: March 2012

AbstractChemical synthesis and in vivo diuretic activity are described.
ChemInform Abstract: Synthesis of New Pyrroles of Potential Antiinflammatory Activity.
Authors: Mohamed Mosaad S. , Kamel Rehab , Fathallah Samar S. 
Published: March 2012

AbstractNovel pyrrole derivatives and pyrrolo[2,3‐d]pyrimidine derivatives are synthesized and some of them are tested for their in vivo antiinflammatory activity.
ChemInform Abstract: Stereoselective Synthesis and Rearrangement‐Fragmentation of Arylidene N‐Alkoxydiketopiperazines.
Authors: Liu Shouxin , Mu Yun , Han Jianrong , Zhen Xiaoli , Yang Yihua , Tian Xia , Whiting Andrew 
Published: March 2012

AbstractNovel title compounds (II) are prepared via intramolecular acylation of oxime‐ethers (I).
ChemInform Abstract: Two New Cembranes from a Formosan Soft Coral Sinularia facile
Authors: Chen Bo‐Wei , Su Jui‐Hsin , Dai Chang‐Feng , Sung Ping‐Jyun , Wu Yang‐Chang , Lin Ying‐Ting , Sheu Jyh‐Horng 
Published: March 2012

Abstractisolation, structure elucidation and cytotoxicity of hydroxycembranes (I) and (II) and 2 known compounds
ChemInform Abstract: Microwave‐Assisted Claisen Rearrangement/Diels—Alder Cascade Reaction for the Synthesis of Caged Garcinia Natural Products and Analogues.
Authors: Li Xiang , Zhang Xiaojin , Yu Zhuoqin , Liu Xiaorong , You Qidong , Guo Qinglong 
Published: March 2012

AbstractThe regioselectivity observed in the cascade reaction is discussed under consideration of both electronic and steric effects.
ChemInform Abstract: Efficient Indole‐Based Receptor for Cu2+ Ion.
Authors: Geng Huamei , Liu Na , Tian Xin , Li Rong , Ma Jiantai 
Published: March 2012

AbstractThe new fluorescent sensor (I) exhibits good selectivity for Cu2+ ion in the 10‐7 to 10‐5 M range over other cations such as K+, Na+, Ca2+, Cr2+, Mg2+, Zn2+, Al3+, and Fe3+ in ethanol.
ChemInform Abstract: Design of Small‐Molecule Thrombin Inhibitors Based on the cis‐5‐Phenylproline Scaffold.
Authors: Kudryavtsev K. V. , Shulga D. A. , Chupakhin V. I. , Churakov A. V. , Datsuk N. G. , Zabolotnev D. V. , Zefirov N. S. 
Published: March 2012

AbstractMolecular docking studies, analysis of ligand‐protein interactions, followed by multistage targeted syntheses and biochemical investigations provide a series of novel nonbasic small‐molecule compounds based on the cis‐5‐phenylproline molecular scaffold.
ChemInform Abstract: First Total H+/Li+ Ion Exchange in Garnet‐Type Li5La3Nb2O12 Using Organic Acids and Studies on the Effect of Li Stuffing.
Authors: Truong Lina , Thangadurai Venkataraman 
Published: March 2012

AbstractLi5+xBaxLa2‐xNb2O12 exhibits H+/Li+ ion exchange using AcOH at room temperature of about 100, 40, and 13% completion for the x = 0, 0.5, and 1 species, respectively.
ChemInform Abstract: Synthesis, Characterization and Cytotoxic Activity of New Salicylaldehyde Benzoylhydrazone Derivatives as Potential Antiproliferative Agents.
Authors: Nikolova‐Mladenova Boriana , Halachev Nenko , Iankova Rumjana , Momekov Georgi , Ivanov Darvin 
Published: March 2012

AbstractThe cytotoxic effects of new hydrazones (I) are examined on a wide spectrum of human tumor cell lines.
ChemInform Abstract: Practically Usable C3 Building Blocks for the Synthesis of Nitro Heterocycles
Authors: Nishiwaki Nagatoshi , Hirao Shotaro , Sawayama Jun , Saigo Kazuhiro 
Published: March 2012

AbstractReview: e.g. pyridines, pyrimidines, pyrazoles, and diazepines; 68 refs.
ChemInform Abstract: Copper‐Catalyzed Domino Reaction of Heteroallenes Towards Benzo‐Heterocycle Compounds
Authors: Wang Fei , Zhao Peng , Xi Chanjuan 
Published: March 2012

AbstractReview: e.g. bezimidazoles, benzoxazoles, benzothiazoles, and quinazolinones; 53 refs.
Arginase‐1 is a more sensitive marker of hepatic differentiation than HepPar‐1 and glypican‐3 in fine‐needle aspiration biopsies
Authors: Fujiwara Mika , Kwok Shirley , Yano Hirohisa , Pai Reetesh K. 
Published: March 2012

AbstractBACKGROUND:Distinguishing hepatocellular carcinoma (HCC) from adenocarcinoma in fine‐needle aspiration biopsies (FNAB) is often diagnostically challenging. Arginase‐1 was recently described as a marker of hepatic differentiation in surgical resection specimens. We compared the expression of arginase‐1, HepPar‐1, and glypican‐3 in FNAB of HCC and adenocarcinoma involving the liver.METHODS:Ninety‐eight FNABs including 37 primary or metastatic HCCs (30 well or moderately differentiated and 7 poorly differentiated) and 61 adenocarcinomas involving the liver were evaluated for immunohistochemical expression of arginase‐1, HepPar‐1, and glypican‐3 using formalin‐fixed paraffin‐embedded cell block material.RESULTS:Arginase‐1 was more sensitive (81%) than HepPar‐1 (70%) or glypican‐3 (54%) for HCC. Arginase‐1 more often demonstrated diffuse staining, defined as reactivity in >50% of the tumor, in HCC (21 of 37; 57%) compared with HepPar‐1 (15 of 37; 41%) and glypican‐3 (12 of 37; 32%). Of the 7 poorly differentiated HCCs, 3 (43%) were immunoreactive for both arginase‐1 and glypican‐3, whereas only 1 (14%) demonstrated HepPar‐1 staining. Arginase‐1 expression was identified in adenocarcinomas of pancreatic, colorectal, and breast origin, and reactivity was diffuse in 2 pancreatic adenocarcinomas (2 of 15; 13%).CONCLUSIONS:Arginase‐1 is a more sensitive marker of hepatic differentiation than either HepPar‐1 or glypican‐3 in FNAB. In addition, arginase‐1 exhibits more diffuse staining in HCC than either HepPar‐1 or glypican‐3, making interpretation easier in limited FNAB samples. Arginase‐1 is not entirely specific for hepatic differentiation, as immunoreactivity can be identified in adenocarcinomas, particularly of pancreatic origin. Cancer (Cancer Cytopathol) 2012;. © 2012 American Cancer Society.
Vertical individualism and injustice: The self‐restorative function of revenge
Authors: Zdaniuk Agnes , Bobocel D. Ramona 
Published: March 2012

AbstractIn the current paper, we examine the role of vertical individualism in determining revenge behavior following an injustice. Drawing on existing theory and research, we hypothesized that victims who are more vertically individualistic will be more likely than those who are less vertically individualistic to engage in revenge following the experience of injustice as a means of restoring self‐esteem. The results from three studies—employing different methodologies and operationalizations of revenge—support our reasoning. Moreover, two of the studies provide support for the proposed self‐esteem maintenance mechanism underlying the relation between vertical individualism and revenge. Although much research in psychology and organizational justice has demonstrated that the experience of injustice can threaten one's identity, our data are the first to demonstrate that responding to injustice can restore people's self‐esteem to homeostasis. The present studies thus demonstrate that in some instances revenge may have an intrapsychic benefit for the victim, which helps to explain why some people engage in revenge despite possible negative interpersonal consequences. We discuss implications of our findings for social and organizational justice theory and for potentially mitigating revenge reactions to injustice. Copyright © 2012 John Wiley & Sons, Ltd.
Specific environmental release categories—A tool for improving chemical safety assessment in the EC—report of a multi-stakeholder workshop
Authors: Sättler Daniel , Schnöder Frank , Aust Nannett , Ahrens Andreas , Bögi Christian , Traas Theo , Tolls Johannes 
Published: March 2012

Abstract
In April 2011, experts from industry and authorities met for a workshop to discuss experience and future developments regarding the use of specific environmental release categories (SPERCs) in chemicals safety assessment (CSA) under the European Chemicals Regulation Registration, Evaluation and Authorization of Chemicals (REACH). This article provides a summary of the workshop. It briefly explains what a SPERC is, why SPERCs are needed, where the challenges of the concept are, and what improvements are needed to make SPERCs a useful tool for assessments under REACH. Integr Environ Assess Manag 2012; 8: 580–585. © 2012 SETAC
Generic Construction of Kraus Operators: d‐level Systems in a Thermal Bosonic Bath
Authors: Biswas Asoka , Brumer Paul 
Published: March 2012

AbstractThe dynamical evolution of open systems can be conveniently expressed in the operator sum representation in terms of Kraus operators. Here we introduce an expression for the canonical Kraus representation in terms of the eigenstates |γ〉 and eigenvalues Eγ of the total Hamiltonian, thus making a stronger connection to the tools in chemistry. The method is exact, and hence valid for non‐Markovian evolution of the system to all orders of the coupling to the bath. Significantly, it provides a starting point for developing approximate Kraus operators based upon perturbative approximations to |γ〉 and Eγ. As an example, the explicit form of these operators is derived for a d‐level system interacting with a single‐mode thermal bath.
Preparation, characterization, and in vitro enzymatic degradation of chitosan‐gelatine hydrogel scaffolds as potential biomaterials
Authors: Gorgieva Selestina , Kokol Vanja 
Published: March 2012

AbstractThe crosslinking of chitosan (CHT) and gelatin (GEL) accomplished with N‐(3‐dimethylaminopropyl)‐N′‐ethylcarbodiimide hydrochloride (EDC) and N‐hydroxysuccinimide (NHS) was investigated and optimized in relation to hydrogels stability by varying the CHT/GEL mass ratio and the EDC/NHS molar ratio at different and constant EDC concentrations. Hydrogels were also fabricated in the presence of α‐tocopherol to assess the release mechanism of a lipophilic drug from a highly‐hydrophilic CHT/GEL hydrogel network. Alterations in the physico‐chemical properties of hydrogels were characterized by differential scanning calorimetry (DSC) and fourier transform infrared spectroscopy (FTIR), and their biostability was studied within a simulated body‐fluid solution (PBS of pH 7.4) at 37°C for 24 h by evaluating the degree of swelling, followed by topography and morphology characterization using scanning electron microscopy (SEM). The analysis confirmed the formation of a modulated hydrogels porosity using different freezing temperatures prior to lyophilization. The in vitro degradation behaviors of the hydrogels were investigated for up to 5 weeks using collagenase, lysozyme, and N‐acetyl‐β‐D‐glucosaminidase by monitoring the weight‐losses of hydrogels and their degradation products, being identified by UV‐Vis spectroscopy and high‐performance liquid chromatography (HPLC) as well as the pH monitoring of degraded solutions. It was observed that an inner morphological hydrogel structure influences their swelling and degradation behavior, which is additionally reduced by in‐gel‐embedded α‐tocopherol because of hydrophobic interactions with their constituents, and hindering the effect on collagenase activity. © 2012 Wiley Periodicals, Inc. J Biomed Mater Res Part A, 2012.
Early detection of impending physiologic deterioration among patients who are not in intensive care: Development of predictive models using data from an automated electronic medical record
Authors: Escobar Gabriel J. , LaGuardia Juan Carlos , Turk Benjamin J. , Ragins Arona , Kipnis Patricia , Draper David 
Published: March 2012

AbstractBACKGROUND:Ward patients who experience unplanned transfer to intensive care units have excess morbidity and mortality.OBJECTIVE:To develop a predictive model for prediction of unplanned transfer from the medical–surgical ward to intensive care (or death on the ward in a patient who was “full code”) using data from a comprehensive inpatient electronic medical record (EMR).DESIGN:Retrospective case‐control study; unit of analysis was a 12‐hour patient shift. Shifts where a patient experienced an unplanned transfer were event shifts; shifts without a transfer were comparison shifts. Hospitalization records were transformed into 12‐hour shift records, with 10 randomly selected comparison shifts identified for each event shift. Analysis employed logistic regression and split validation.SETTING:Integrated healthcare delivery system in Northern California.PATIENTS:Hospitalized adults at 14 hospitals with comprehensive inpatient EMRs.MEASUREMENTS:Predictors included vital signs, laboratory test results, severity of illness scores, longitudinal chronic illness burden scores, transpired hospital length of stay, and care directives. Patients were also given a retrospective, electronically (not manually assigned) Modified Early Warning Score, or MEWS(re). Outcomes were transfer to the intensive care unit (ICU) from the ward or transitional care unit, or death outside the ICU among patients who were “full code”.RESULTS:We identified 4,036 events and 39,782 comparison shifts from a cohort of 102,422 patients' hospitalizations. The MEWS(re) had a c‐statistic of 0.709 in the derivation and 0.698 in the validation dataset; corresponding values for the EMR‐based model were 0.845 and 0.775.LIMITATIONS:Using these algorithms requires hospitals with comprehensive inpatient EMRs and longitudinal data.CONCLUSIONS:EMR‐based detection of impending deterioration outside the ICU is feasible in integrated healthcare delivery systems. Journal of Hospital Medicine 2012;. © 2012 Society of Hospital Medicine