bluuebunny/crossref_metadata_2025_split huggingface dataset:
Upwelling signals in radiocarbon from early 20th-century Peruvian bay scallop (Argopecten purpuratus) shells
Authors: Jones Kevin B. , Hodgins Gregory W.L. , Etayo-Cadavid Miguel F. , Andrus C. Fred T. 
Published: August 2009

AbstractWe quantified Δ14C, δ18O, and δ13C cycles along ontogeny within four bay scallop (Argopecten purpuratus) shells collected from Callao Bay, Salaverry, and Sechura Bay, Peru following the 1907–1908 non-El Niño years and the 1925–1926 El Niño. Δ14C and δ13C generally covary; Δ14C and δ18O vary inversely. Simultaneous decreases in Δ14C and increases in δ18O in non-El Niño shells are followed by constant Δ14C and gradually decreasing δ18O, which we interpret as evidence for discrete marine upwelling events followed by warming of the initially cold upwelled water. Upwelling changes from El Niño events are detectable with difficulty in mollusk shell Δ14C.
Ileal digestibility of dietary protein in the growing pig and adult human
Authors: Deglaire Amélie , Bos Cécile , Tomé Daniel , Moughan Paul J. 
Published: August 2009

The suitability of the pig as an animal model for predicting protein digestibility in man was evaluated. Healthy adult human subjects (mean body weight 67 kg;n11) and growing pigs (mean body weight 40 kg;n15) were fed semi-synthetic mixed meals containing, as a sole source of N, casein (C), hydrolysed casein (HC) or rapeseed isolate (R). There was no prior adaptation to the test meal. Ileal digesta were sampled through a naso-ileal tube (human subjects) or a post-valve T-caecum cannula (pigs) after ingestion of a bolus meal. The protein sources were15N-labelled. Amino acid (AA) digestibilities were not determined for R. Ileal apparent N digestibility was markedly lower (14–16 %;P < 0·001) in human subjects than in pigs (C, HC, R). Similarly, most apparent ileal AA digestibilities were lower (8 % on average;P < 0·05) in human subjects (C, HC). Ileal true N digestibility was slightly lower (3–5 %;P < 0·001) in human subjects than in pigs (C, HC, R) and most true ileal AA digestibilities were similar (P>0·05) between the species (C, HC). Exceptions were for phenylalanine, tyrosine, lysine, histidine and aspartic acid for which digestibilities were lower (3 % on average;P < 0·001) in human subjects. A similar ranking of the diets was observed for true ileal N digestibility between species. The inter-species correlation for true ileal digestibility was high for N (r0·98 over 3 × 2 data;P = 0·11) and AA (r0·87 over 26 × 2 data;P < 0·0001). Overall, this supports the use of the pig as a model for predicting differences among dietary protein digestibility, especially regarding true ileal N digestibility, in man.
Soya protein does not affect glycaemic control in adults with type 2 diabetes
Authors: Gobert Colleen P. , Pipe Elizabeth A. , Capes Sarah E. , Darlington Gerarda A. , Lampe Johanna W. , Duncan Alison M. 
Published: August 2009

Evidence from observational, animal and human studies supports a role for soya protein and its isoflavones in the improvement of glycaemic control in type 2 diabetes. The objective of the present study was to determine the effect of isoflavone-rich soya protein on markers of glycaemic control in adults with type 2 diabetes. Using a randomised, crossover, double-blind, placebo-controlled design, adults with diet-controlled type 2 diabetes (n 29) consumed soya protein isolate (SPI) and milk protein isolate (MPI) for 57 d each separated by a 4-week washout. Blood was collected on days 1 and 57 of each treatment period for analysis of fasting HbA1C, and fasting and postprandial glucose, insulin and calculated indices of insulin sensitivity and resistance. Urine samples of 24 h were collected at the end of each treatment period for analysis of isoflavones. Urinary isoflavone excretion was significantly greater following consumption of SPI compared with MPI, and 20·7 % of the subjects (n 6) were classified as equol excretors. SPI consumption did not significantly affect fasting or postprandial glucose or insulin, fasting HbA1C, or indices of insulin sensitivity and resistance. These data do not support a role for soya protein in the improvement of glycaemic control in adults with diet-controlled type 2 diabetes and contribute to a limited literature of human studies on the effects of soya protein on the management of type 2 diabetes.
Information design to promote better nutrition among pantry clients: four methods of formative evaluation
Authors: Evans Susan H , Clarke Peter , Koprowski Carol 
Published: August 2009

AbstractObjectiveTo demonstrate the use of four different qualitative methods in creating content, including text and graphic design for print interventions to support better nutrition in low-income households that rely on charitable pantries.DesignFour methods were used for measuring household cooks’ responses to the content and design of recipes and food-use tips especially designed for low-income households: (i) focus groups with pantry clients; (ii) questionnaires administered at sites where the Women, Infants and Children (WIC) programme beneficiaries gather, to survey cooks’ judgements about the appeal of recipes; (iii) recruitment of WIC clients to prepare recipes at home, followed by phone interviews about the cooks’ actual experiences preparing and serving dishes; and (iv) a new technique to gauge pantry clients’ preferred ordering of print information, using bits of content backed by Velcro™ strips that participants applied to felt boards. Ten sets of illustrated recipes and food-use tips were prepared, each set focusing on a different fresh vegetable that is periodically available from charitable sources.SubjectsLow-income recipients of food from community pantries in the USA, and beneficiaries of the WIC programme.ResultsIllustrative findings show how the four types of qualitative evaluations can inform decisions about content and about graphic design. Discoveries from this formative research illuminate challenges of supporting better nutrition among households that depend on charitable sources of food supply.ConclusionsThese multi-method evaluation techniques can be adapted to the development of any print material, whether intended for widespread dissemination or for field research into nutrition behaviour.
Children’s magazines: reading resources or food marketing tools?
Authors: Jones Sandra C , Reid Amanda 
Published: August 2009

AbstractObjectiveMagazines targeted at children under 12 years old are growing in popularity; past studies have asserted that food items are rarely exposed, but methodological issues may have covered the true extent of covert promotion. The primary purpose of the present study was to quantify the nature and extent of the promotion of branded food products in Australian children’s magazines.DesignWe conducted a content analysis of possible food promotions in seven top-selling Australian children’s magazines published in 2005. In addition to regular food advertisements, the number of advertisements for premiums, editorials, puzzles or games, competitions and branded non-food promotions by food companies was recorded. Category frequencies are reported with a detailed description of the promotions present during September 2005.ResultsOnly fifty-eight out of the 444 items identified could be classed as regular food advertisements. Several advertisements appeared to be in breach of codes regarding advertising to children and premiums.ConclusionsThe pervasiveness of covert food marketing in the present study was contrary to previous findings and raises questions about the effectiveness of legal restrictions and self-regulation of advertising in protecting children from commercial food messages that may not be regarded as advertising.
Halo effect of a weight-loss trial on spouses: the DIRECT-Spouse study
Authors: Golan Rachel , Schwarzfuchs Dan , Stampfer Meir J , Shai Iris 
Published: August 2009

AbstractObjectiveWe examined the halo effect of a 2-year weight-loss diet trial, the Dietary Intervention Randomized Controlled Trial (DIRECT), on the weight and nutritional patterns of participants' spouses.DesignDIRECT participants in a research centre workplace were randomly assigned to one of three diets: Low-fat, Mediterranean or Low-carbohydrate. A sample of wives of the DIRECT participants, who attended support update meetings specific to their husband's diet during the first 6 months, were followed for 2 years.SettingSouth Israel.SubjectsSeventy-four women (mean age = 51 years, mean BMI =26·6 kg/m2).ResultsAmong the wives of husbands randomised to the Low-fat, Mediterranean and Low-carbohydrate diet, self-reported weight change was respectively −1·48 kg, −2·30 kg and −4·62 kg after 6 months, and +0·39 kg, −3·00 kg and −2·30 kg after 2 years. Weight loss among wives whose husbands were in the alternative diet groups combined (Mediterranean+Low-carbohydrate) was significantly greater than among wives whose husbands were in the Low-fat group after 6 months (P = 0·031) and 2 years (P = 0·034). Overweight wives experienced more weight loss. The weight change of couples was significantly correlated (r = 0·42, P < 0·001). Across all dietary groups, wives had significant improvement in their dietary patterns in all food groups according to their husbands' diets, mainly by a larger significant decrease in carbohydrate consumption in the Low-carbohydrate group (P = 0·013 compared to Low-fat). Six-month weight change among the seventy-four DIRECT participants whose wives took part in the group support sessions was −5·2 kg, compared to −3·5 kg among the 248 DIRECT participants whose wives did not take part in these sessions (P = 0·020).ConclusionsFocusing on the couple as a unit could provide a cost-effective approach to weight-loss programmes.
Understanding the nineteenth century origins of disciplines: lessons for astrobiology today?
Authors: Brazelton William J. , Sullivan Woodruff T. 
Published: August 2009

AbstractAstrobiology's goal of promoting interdisciplinary research is an attempt to reverse a trend that began two centuries ago with the formation of the first specialized scientific disciplines. We have examined this era of discipline formation in order to make a comparison with the situation today in astrobiology. Will astrobiology remain interdisciplinary or is it becoming yet another specialty?As a case study, we have investigated effects on the scientific literature when a specialized community is formed by analyzing the citations within papers published during 1802–1856 in Philosophical Transactions of the Royal Society (Phil. Trans.), the most important ‘generalist’ journal of its day, and Transactions of the Geological Society of London (Trans. Geol. Soc.), the first important disciplinary journal in the sciences. We find that these two journals rarely cited each other, and papers published in Trans. Geol. Soc. cited fewer interdisciplinary sources than did geology papers in Phil. Trans. After geology had become established as a successful specialized discipline, geologists returned to publishing papers in Phil. Trans., but they wrote in the new, highly specialized style developed in Trans. Geol. Soc. They had succeeded in not only creating a new scientific discipline, but also a new way of doing science with its own modes of research and communication.A similar citation analysis was applied to papers published over the period 2001–2008 in the contemporary journals Astrobiology and the International Journal of Astrobiology to test the hypothesis that astrobiologists are in the early stages of creating their own specialized community. Although still too early to reliably detect any but the largest trends, there is no evidence yet that astrobiologists are drifting into their own isolated discipline. Instead, to date they appear to remain interdisciplinary.
Contingent valuation: what needs to be done?
Authors: Smith Richard D. , Sach Tracey H. 
Published: August 2009

AbstractContingent valuation (CV) has been argued to have theoretical advantages over other approaches for benefit valuation used by health economists. Yet, in reality, the technique appears not to have realised these advantages when applied to health-care issues, such that its influence in decision-making at national levels has been non-existent within the health sector. This is not a result of a lack of methodological work in the area, which has continued to flourish. Rather, it is a result of such activities being undertaken in a rather uncoordinated and unsystematic fashion, leading CV to be akin to a ‘ship without a sail’. This paper utilises a systematic review of the CV literature in health to illustrate some important points concerning the conduct of CV studies, before providing a comment on what the remaining policy and research priorities are for the technique, and proposing a guideline for such studies. It is hoped that this will initiate some wider and rigorous debate on the future of the CV technique in order to make it seaworthy, give it direction and provide the right momentum.
Direct Magnitude Estimation of Articulation Rate in Boys With Fragile X Syndrome
Authors: Zajac David J. , Harris Adrianne A. , Roberts Joanne E. , Martin Gary E. 
Published: August 2009

PurposeTo compare the perceived articulation rate of boys with fragile X syndrome (FXS) with that of chronologically age-matched (CA) boys and to determine segmental and/or prosodic factors that account for perceived rate.MethodTen listeners used direct magnitude estimation procedures to judge the articulation rates of 7 boys with FXS only, 5 boys with FXS and a diagnosis of autism spectrum disorder (ASD), and 12 CA boys during sentence repetition. Sentences had similar articulation rates in syllables per second as determined acoustically. Four segmental/prosodic factors were used to predict perceived rate: (a) percentage consonants correct, (b) overall fundamental frequency (F0) level, (c) sentence-final F0drop, and (d) acoustically determined articulation rate with the final word of the sentence excluded.ResultsBoys with FXS and ASD were judged to talk faster than CA controls. Multiple linear regression indicated that articulation rate with the final word of the sentence excluded and sentence-final F0drop accounted for 91% of the variance for perceived rate.ConclusionsDescriptions of speakers with FXS as having fast and/or fluctuating articulation rates may be influenced by autism status. Also, atypical sentence-final prosody may be related to perceived rate in boys with FXS and ASD.
Clinical and Molecular Epidemiology of Human Rhinovirus C in Children and Adults in Hong Kong Reveals a Possible Distinct Human Rhinovirus C Subgroup
Authors: Lau Susanna K. P. , Yip Cyril C. Y. , Lin Ada W. C. , Lee Rodney A. , So Lok-Yee , Lau Yu-Lung , Chan Kwok-Hung , Woo Patrick C. Y. , Yuen Kwok-Yung 
Published: August 2009

Abstract
BackgroundA novel human rhinovirus (HRV) species, HRV-C, was recently discovered, but its clinical features and epidemiology, compared with HRV-A and HRV-B, remains poorly understood, especially in adults
MethodsOne thousand two hundred nasopharyngeal aspirate samples obtained from hospitalized children and adults during a 1-year period were subject to reverse-transcriptase polymerase chain reaction to detect HRV. The clinical and molecular epidemiology of the 3 HRV species was analyzed
ResultsHRVs were detected in 178 (29.7%) of 600 nasopharyngeal aspirate samples from children and 42 (7%) of 600 nasopharyngeal aspirate samples from adults. HRV-A was most prevalent (n=111), followed by HRV-C (n=91) and HRV-B (n=18). Although upper respiratory tract infection was the most common presentation in children, 8 (62%) of the 13 adults with HRV-C infection had pneumonia, compared with 6 (27%) of the 22 adults with HRV-A infection (P&lt;.05). Wheezing episodes were also more common among individuals with HRV-C (37%) and HRV-A (20%) infection than among those with HRV-B (0%) infection (P&lt;.05). Clinical and molecular data analysis revealed HRV-C as a frequent cause of community and institutionalized outbreaks. A diverse set of HRV-C genotypes was circulating throughout the year, among which a potential distinct subgroup of strains was observed
ConclusionHRV-C is associated with pneumonia in adults and outbreaks of respiratory infections requiring hospitalization. A potential novel HRV-C subgroup was identified
Medical and Nursing Students with Suboptimal Protective Immunity against Vaccine-Preventable Diseases
Authors: Pavlopoulou Ioanna D. , Daikos George L. , Tzivaras Andreas , Bozas Evangelos , Kosmidis Chris , Tsournakas Constantinos , Theodoridou Maria 
Published: August 2009

Objectives.Medical and nursing students (hereafter referred to as “healthcare students”) are at risk of contracting and transmitting infectious diseases in a hospital Setting. The aim of our study was to evaluate the vaccination history of healthcare students and their serologic immunity against vaccine-preventable diseases.Design.Prospective cohort study.Setting.A tertiary care children's hospital in Athens, Greece, which is affiliated with the University of Athens.Methods.Healthcare students were recruited during April through November 2007. The information obtained from these students during personal interviews included demographics and whether there was a history of varicella, measles, mumps, rubella, and/or hepatitis A or B virus infection. Vaccination history and documentation of disease were abstracted from available medical records. Serum antibodies against the above-mentioned viral agents were determined by use of an enzyme-linked immunosorbent assay. Seronegative students and those with immunization gaps were referred to local vaccination clinics, and compliance was assessed 3 months later.Results.A total of 187 healthcare students were recruited, 131 (70.1%) of whom provided complete documentation of vaccination history. Adequate immunity against diphtheria and tetanus was documented for 55 (37.2%) and 73 (49.3%) of the 148 participants, respectively, whereas age-appropriate vaccination against pertussis, diphtheria, tetanus, and poliomyelitis was noted for 138 (93.2%), 147 (99.3%), 147 (99.3%), and 147 (99.3%) healthcare students, respectively. Of 185 healthcare students, 171 (92.4%) were immune to varicella. Of 182 healthcare students, 179 (98.4%) were immune to measles, 163 (89.6%) were immune to mumps, and 176 (96.7%) were immune to rubella. Of 179 healthcare students, 151 (84.4%) were immune to hepatitis B virus. Of 178 healthcare students, 26 (14.6%) were immune to hepatitis A virus. Antibodies (10 IU/L or higher) to hepatitis B surface antigen were detected for 151 (84.4%) of 179 healthcare students, and antibodies (10 IU/L or higher) to hepatitis A virus were detected for 26 (14.6%) of 178 healthcare students. Fewer than 30% of participants were in full compliance with recommended vaccinations.Conclusions.We have determined that there is a certain proportion of healthcare students who are susceptible to certain vaccine-preventable diseases. The development of an appropriate vaccination strategy is required to decrease the risk of transmission in a hospital setting.
Next generation software for functional trend analysis
Authors: Berriz Gabriel F. , Beaver John E. , Cenik Can , Tasan Murat , Roth Frederick P. 
Published: August 2009

Abstract
Summary: FuncAssociate is a web application that discovers properties enriched in lists of genes or proteins that emerge from large-scale experimentation. Here we describe an updated application with a new interface and several new features. For example, enrichment analysis can now be performed within multiple gene- and protein-naming systems. This feature avoids potentially serious translation artifacts to which other enrichment analysis strategies are subject.
Availability: The FuncAssociate web application is freely available to all users at http://llama.med.harvard.edu/funcassociate.
Contact: fritz_roth@hms.harvard.edu
LBD18/ASL20Regulates Lateral Root Formation in Combination withLBD16/ASL18Downstream ofARF7andARF19in Arabidopsis
Authors: Lee Han Woo , Kim Nan Young , Lee Dong Ju , Kim Jungmook 
Published: August 2009

AbstractThe LATERAL ORGAN BOUNDARIES DOMAIN/ASYMMETRIC LEAVES2-LIKE (LBD/ASL) genes encode proteins harboring a conserved amino acid domain, referred to as the LOB (for lateral organ boundaries) domain. While recent studies have revealed developmental functions of some LBD genes in Arabidopsis (Arabidopsis thaliana) and in crop plants, the biological functions of many other LBD genes remain to be determined. In this study, we have demonstrated that the lbd18 mutant evidenced a reduced number of lateral roots and that lbd16 lbd18 double mutants exhibited a dramatic reduction in the number of lateral roots compared with lbd16 or lbd18. Consistent with this observation, significant β-glucuronidase (GUS) expression in ProLBD18:GUS seedlings was detected in lateral root primordia as well as in the emerged lateral roots. Whereas the numbers of primordia of lbd16, lbd18, and lbd16lbd18 mutants were similar to those observed in the wild type, the numbers of emerged lateral roots of lbd16 and lbd18 single mutants were reduced significantly. lbd16 lbd18 double mutants exhibited additively reduced numbers of emerged lateral roots compared with single mutants. This finding indicates that LBD16 and LBD18 may function in the initiation and emergence of lateral root formation via a different pathway. LBD18 was shown to be localized into the nucleus. We determined whether LBD18 functions in the nucleus using a steroid regulator-inducible system in which the nuclear translocation of LBD18 can be regulated by dexamethasone in the wild-type, lbd18, and lbd16 lbd18 backgrounds. Whereas LBD18 overexpression in the wild-type background induced lateral root formation to some degree, other lines manifested the growth-inhibition phenotype. However, LBD18 overexpression rescued lateral root formation in lbd18 and lbd16lbd18 mutants without inducing any other phenotypes. Furthermore, we demonstrated that LBD18 overexpression can stimulate lateral root formation in auxin response factor7/19 (arf7 arf19) mutants with blocked lateral root formation. Taken together, our results suggest that LBD18 functions in the initiation and emergence of lateral roots, in conjunction with LBD16, downstream of ARF7 and ARF19.
ArabidopsisSTN7 Kinase Provides a Link between Short- and Long-Term Photosynthetic Acclimation
Authors: Pesaresi Paolo , Hertle Alexander , Pribil Mathias , Kleine Tatjana , Wagner Raik , Strissel Henning , Ihnatowicz Anna , Bonardi Vera , Scharfenberg Michael , Schneider Anja , Pfannschmidt Thomas , Leister Dario 
Published: August 2009

AbstractFlowering plants control energy allocation to their photosystems in response to light quality changes. This includes the phosphorylation and migration of light-harvesting complex II (LHCII) proteins (state transitions or short-term response) as well as long-term alterations in thylakoid composition (long-term response or LTR). Both responses require the thylakoid protein kinase STN7. Here, we show that the signaling pathways triggering state transitions and LTR diverge at, or immediately downstream from, STN7. Both responses require STN7 activity that can be regulated according to the plastoquinone pool redox state. However, LTR signaling does not involve LHCII phosphorylation or any other state transition step. State transitions appear to play a prominent role in flowering plants, and the ability to perform state transitions becomes critical for photosynthesis in Arabidopsis thaliana mutants that are impaired in thylakoid electron transport but retain a functional LTR. Our data imply that STN7-dependent phosphorylation of an as yet unknown thylakoid protein triggers LTR signaling events, whereby an involvement of the TSP9 protein in the signaling pathway could be excluded. The LTR signaling events then ultimately regulate in chloroplasts the expression of photosynthesis-related genes on the transcript level, whereas expression of nuclear-encoded proteins is regulated at multiple levels, as indicated by transcript and protein profiling in LTR mutants.