bluuebunny/crossref_metadata_2025_split huggingface dataset:
Assessing disordered speech and voice in Parkinson's disease: a telerehabilitation application
Authors: Constantinescu Gabriella , Theodoros Deborah , Russell Trevor , Ward Elizabeth , Wilson Stephen , Wootton Richard 
Published: January 2010

Background: Patients with Parkinson's disease face numerous access barriers to speech pathology services for appropriate assessment and treatment. Telerehabilitation is a possible solution to this problem, whereby rehabilitation services may be delivered to the patient at a distance, via telecommunication and information technologies. A number of studies have demonstrated the capacity of telerehabilitation to provide reliable and valid assessments of speech, voice and language. However, no studies have specifically focused on assessing patients with Parkinson's disease.Aims: To investigate the validity and reliability of a telerehabilitation application for assessing the speech and voice disorder associated with Parkinson's disease.Methods & Procedures: Sixty‐one participants with Parkinson's disease and hypokinetic dysarthria were simultaneously assessed in an online and face‐to‐face environment by two speech–language pathologists. The assessment protocol included perceptual measures of voice and oromotor function, articulatory precision, speech intelligibility, and acoustic measures of vocal sound pressure level, phonation time and pitch range. Online assessments were conducted via a personal computer‐based videoconferencing system with store‐and‐forward capabilities, operating on a 128 kbit/s Internet connection. The level of agreement between the online and face‐to‐face ratings was determined using several different analyses, depending on the parameter. These included per cent close agreement, quadratic weighted Kappa, and the Bland and Altman limits of agreement.Outcomes & Results: Per cent close agreement between the two environments was within a predetermined clinical criterion of 80% agreement for all voice and oromotor parameters, articulatory precision and speech intelligibility in conversation. Levels of agreement between the environments, based on quadratic weighted Kappa, ranged from poor to good for vocal parameters and from fair to very good for oromotor parameters. Bland and Altman limits of agreement analyses revealed comparability between online and face‐to‐face environments for vocal sound pressure level, phonation time, pitch range, sentence intelligibility and communication efficiency in reading. Intra‐ and inter‐rater reliability scores for all tasks were comparable between the online and face‐to‐face environments.Conclusions & Implications: For the majority of parameters, comparable levels of agreement were achieved between the two environments. Online assessment of disordered speech and voice in Parkinson's disease appears to be valid and reliable. The telerehabilitation application described in this study provides evidence for the delivery of online assessment for the dysarthric speech disorder associated with Parkinson's disease.
THE LEPIDOPTERA OF THE SETON LAKE REGION, BRITISH COLUMBIA
Authors: McDunnough J. 
Published: January 2010

Nemoria darwiniata Dyar. A single ♀, June 15.Nemoria hudsonaria Tayl. Quite common during the latter half of June. In a few of the specimens the inner transverse lines are obsolete and these could as well be placed under unilinearia Tayl. as under hudsonaria. I am not sure at the present time whether the differences given by Taylor are of specific value and until I can study the matter further I use the older of the two names.
NEW SPECIES OF LABOPIDEA AND MACROTYEOIDES (HEMIPTERA, MIRIDAE)
Authors: Knight Harry H. 
Published: January 2010

Allied to simplex Uhler, but distinguished by the fine, uniformly pale pubescence, shorter rostrum and more tumid frons.♂ .Length 5 mm., width 1.8 mm. Head: width 1.09 mm., vertex 666 mm.; frons more tumid than in simplex, pale greenish, becoming fuscous each side of frons and a spot each side of vertex. Rostrum, length 1.09 mm., just attaining hind margin of sternum, pale greenish, last two segments blackish. Antennae: segment I, length .42mm.; II, 1.6 mm.; III, 1.18 mm.; IV, broken; black. Pronotum: length .72 mm., width at base 1.54 mm.; calli becoming blackish on hind margins.
A NEW PTENIDIUM FROM CALIFORNIA (COLEOP.)
Authors: Psota F. J. , Ray E. 
Published: January 2010

Subelliptical-elongate, upper surface of body clothed with short, silvery pubescence. Head and thorax black; elytra rufo-castaneous, with suture darker.Head rounded in front, three strong foveae in a line near the base. Eyes coarsely granulate. Mouth parts and antennae flavous, the latter with a slender club composed of the last three joints.
NEW COLEOPTERA XIII
Authors: Fall H. C. 
Published: January 2010

Elongate, entire body and antennae ferruginous, legs a little paler; pubescence very short, yellowish gray, lustre dull from the density of the punctuation.Head nearly as wide as the prothorax, densely punctate, feebly broadly impressed. Antennae slender, passing by one or two joints the hind angles of the thorax, 3rd joint slightly longer than the 2nd, these together subequal to the 4th.
NOTES ON THE PITYOPHTHORINAE (COLEOPT. IPIDAE): I. DESCRIPTION OF NEW SPECIES
Authors: Schedl K. E. 
Published: January 2010

Description of the adult female. Dark brown in colour; 2.00 mm. long, 2.62 times as long as wide, allied to ponderosae Blackm.Front of the head plano-convex below, closely, moderately finely punctured, coarser and sparsely on vertex, the interspaces between the punctures minutely reticulate; longitudinal carina moderately strongly developed and elevated, extending from the slightly arcuate epistomal margin up to a level of the upper angle of the eyes; indistinctly clothed with short yellow hairs.
NOTES ON THE PITYOPHTHORINAE (COLEOPTERA IPIDAE) II THREE NEW SPECIES
Authors: Schedl K. 
Published: January 2010

Female. Dark brown in colour; 2.37 mm. long, 2.62 times as long as wide; allied to various Schedl.Front flattened on a semicircular area below, rather finely moderately closely punctured, interspaces finely rugose, with very fine, inconspicuous hairs and with a distinctly but not strongly developed longitudinal carina which extends up to a level of the middle of the eyes; antennae concolourous, club 1.65 times as long as the funicle, 1.33 times as long as wide, first suture straight, second feebly arcuate, third strongly arcuate; eyes moderately coarsely granulate, the inner line emarginate, emargination wider than deep.
OUR IGNORANCE CONCERNING INSECTS
Authors: Lutz Frank E. 
Published: January 2010

Choosing the title of a talk is often a difficult task.Being naturally optimistic, I wanted to speak concerning some recent advances in our knowledge of insects. But coming to Canada with a talk bearing such a title would seem like carrying coals to Newcastle, since many of the recent American advances in entomological knowledge have been made on this side of the line, and, in the English-speaking world as a whole, most of the advances have been made under the British flag. Furthermore, being naturally a timid soul, I feared discrimination in the selection of examples.
NEW COLEOPTERA XV
Authors: Fall H. C. 
Published: January 2010

Moderately slender, parallel, black, the apices of the last two ventral segments narrowly nebulouslly paler; legs pale testaceous; surface shining, the abdomen rather less so, pubescence somewhat obscure in color.Head with a few coarse punctures mostly postero-laterally, with much finer ones sparsely dispersed. Eyes not quite attaining the basal nrargin of the head. Antennae of the usual type, outer joints decreasing in length but all perceptibly longer than wide.
ADDITIONAL NEW RHOPALOCERA (LEPIDOPTERA)
Authors: Gunder J. D. 
Published: January 2010

Papilio cresphontes Cram., tr. f. forsythae new tr f.In typical Florida and southern United States examples of cresphontes, the ground color is pale yellow. In this tr. f. the ground color is a deep canary yellow, practically an orange or burnt umber, similar to Papilio rutulus ammoni Behrens which is well illustrated on pl. I of Comstock's “Butterflies of California.”
NEW COLEOPTERA XVI
Authors: Fall H. C. 
Published: January 2010

Length 5.7 to 6.1 mm., width 1.65 to 1.75 mm. Form narrow, parallel, color piceous bronzed, base of antennae, prosternal lobe and legs reddish, surface moderately shining, distinctly pale pubescent.In size, form, color and all other details except as mentioned below, this species is so similar to the common quercinus as to be practically indistinguishable to the casual eye.
THREE NEW SPECIES OF HYDROPORUS BELONGING TO THE VILIS GROUP. (COLEOPTERA)
Authors: Wallis J. B. 
Published: January 2010

While, as Mr. Fall points out, the species of this group are rather closely allied, there seems to be a number of forms not yet described. Mr. W. J. Brown has recently described two species from British Columbia and the three treated in this paper seem clearly distinct.The distinctions among the species are rather difficult to define, though, with the exception of certain forns of vilis and planiusculus, the differences may be seen clearly when secimens are at hand.
NOTES ON TROPAEA LUNA, ACTIAS SELENE AND THEIR HYBRIDS (LEPID.)
Authors: Wickwire Harriet A. , Calale Adele 
Published: January 2010

On the night of June 4, 1933, we “tied out” seven females of Tropaea luna and by 11 p. m. four of them had found mates.On June 10 at 1.30 p. m., a male and a female Actias selene emerged from cocoons which we had purchased in New York. The following day two males emerged. Copulation occurred with one of these at 11.55 p. m. The mates separated at 2.30 the next morning and the female began ovipositing at once.
TWO NEW SPECIES OF PHLOEOSINUS CHAPUIS (SCOLYTIDAE-COLEOPTERA)
Authors: Bruck C. R. 
Published: January 2010

A small robust species, length 1.5-2.5 mm.Front of the male deeply concave, clothed with short bristle-like hairs, sparsely granulate-punctate, surface opaque, with a long, shining, median carina; second suture of the antennal club subtransverse. Pronotum wider than long, 5.5:3.5; sides slightly rounded, narrowing on the anterior half, constricted behind the anterior margin; the constriction extends across the dorsum, widening on the disk thereby simulating a wide, deep impression on the anterior third; anterior margin is broadly rounded; the surface is moderately clothed with short setae and the punctures are large, dense, and deep.
A NEW ATAENIUS FROM FLORIDA. (COLEOPTERA, SCARABAEIDAE)
Authors: Cartwright O. L. 
Published: January 2010

Oblong oval, convex, piceous opaque. Antennae and palpi rufo-testaceous.Head moderately convex, densely punctate, the punctures across the occiput coarser, those of the front finer and united longitudinally in groups of two or more, single and still finer approaching the clypeus, the clypeus nearly smooth at middle. Clypeus impresseed in front, broadly emarginate, the angles broadly rounded, sides arcuate ; genae obtuse, not prominent.Thorax convex, one-third wider than long, sides sub-parallel, feebly arcuate, the edges partly hidden when viewed directly from above; angles obtuse, the hind angles especially so; base broadly arcuate, marginal line distinct ; punctures rather coarse and close at base and sides, a little finer in front.
THREE NEW SPECIES OF SCOLYTIDAE (COLEOPTERA)
Authors: Swaine J. M. 
Published: January 2010

Length 2.5 mm., width 1.1 mm. Pronotum and elytra equal in width, sides straight and parallel, elytra arcuately narrowed on the caudal third, very broadly obtuse behind; dark reddish brown; pubescence sparse, erect and yellow, more evident about the apex of the pronotum and on the elytral declivity.The head has the frons broadly, feebly convex, the median line feebly carinate with a narrow, transverse epistomal impression, the entire surface subopaque from minute reticulations, marked with sparse, coarse, shallow punctures with minute setae on the caudal half, more finely and closely granulatepunctate in front, the punctures bearing long yellow hairs erect on the frons, longer and recumbent from the transverse impression, forming the epistomal fringe, the epistomal margin smooth, narrow and feebly elevated; the eyes with a deep triangular emargination.
THE COLEOPTERA OF GLACIER PARK, MONTANA
Authors: Mank Edith W. 
Published: January 2010

The following list of beetles is the result of collecting done in Glacier National Park, Montana, during three summer vacations, 1924, 1929, and 1931.It is readily recalled that this park covers an area of fifty miles from north to south and about thirty-five miles from east to west, running along the international boundary.
Age-Associated Decrease in TLR Function in Primary Human Dendritic Cells Predicts Influenza Vaccine Response
Authors: Panda Alexander , Qian Feng , Mohanty Subhasis , van Duin David , Newman Frances K. , Zhang Lin , Chen Shu , Towle Virginia , Belshe Robert B. , Fikrig Erol , Allore Heather G. , Montgomery Ruth R. , Shaw Albert C. 
Published: January 2010

Abstract
We evaluated TLR function in primary human dendritic cells (DCs) from 104 young (age 21–30 y) and older (≥65 y) individuals. We used multicolor flow cytometry and intracellular cytokine staining of myeloid DCs (mDCs) and plasmacytoid DCs (pDCs) and found substantial decreases in older compared with young individuals in TNF-α, IL-6, and/or IL-12 (p40) production in mDCs and in TNF-α and IFN-α production in pDCs in response to TLR1/2, TLR2/6, TLR3, TLR5, and TLR8 engagement in mDCs and TLR7 and TLR9 in pDCs. These differences were highly significant after adjustment for heterogeneity between young and older groups (e.g., gender, race, body mass index, number of comorbid medical conditions) using mixed-effect statistical modeling. Studies of surface and intracellular expression of TLR proteins and of TLR gene expression in purified mDCs and pDCs revealed potential contributions for both transcriptional and posttranscriptional mechanisms in these age-associated effects. Moreover, intracellular cytokine production in the absence of TLR ligand stimulation was elevated in cells from older compared with young individuals, suggesting a dysregulation of cytokine production that may limit further activation by TLR engagement. Our results provide evidence for immunosenescence in DCs; notably, defects in cytokine production were strongly associated with poor Ab response to influenza immunization, a functional consequence of impaired TLR function in the aging innate immune response.
Histone Deacetylase Inhibitors Suppress Inflammatory Activation of Rheumatoid Arthritis Patient Synovial Macrophages and Tissue
Authors: Grabiec Aleksander M. , Krausz Sarah , de Jager Wilco , Burakowski Tomasz , Groot Dion , Sanders Marjolein E. , Prakken Berent J. , Maslinski Wlodzimierz , Eldering Eric , Tak Paul P. , Reedquist Kris A. 
Published: January 2010

Abstract
Macrophages contribute significantly to the pathology of many chronic inflammatory diseases, including rheumatoid arthritis (RA), asthma, and chronic obstructive pulmonary disease. Macrophage activation and survival are tightly regulated by reversible acetylation and deacetylation of histones, transcription factors, and structural proteins. Although histone deacetylase (HDAC) inhibitors (HDACis) demonstrate therapeutic effects in animal models of chronic inflammatory disease, depressed macrophage HDAC activity in patients with asthma, chronic obstructive pulmonary disease, or RA may contribute to inflammation in these diseases, potentially contraindicating the therapeutic administration of HDACis. In this study, we directly examined whether HDACis could influence the activation of macrophages derived from the inflamed joints of patients with RA. We found that inhibition of class I/II HDACs or class III sirtuin HDACs potently blocked the production of IL-6 and TNF-α by macrophages from healthy donors and patients with RA. Two HDACis, trichostatin A and nicotinamide, selectively induced macrophage apoptosis associated with specific downregulation of the antiapoptotic protein Bfl-1/A1, and inflammatory stimuli enhanced the sensitivity of macrophages to HDACi-induced apoptosis. Importantly, inflammatory and angiogenic cytokine production in intact RA synovial biopsy explants was also suppressed by HDACis. Our study identifies redundant, but essential, roles for class I/II and sirtuin HDACs in promoting inflammation, angiogenesis, and cell survival in RA.
The Supersingular Locus of the Shimura Variety for GU(1, s)
Authors: Vollaard Inken 
Published: January 2010

AbstractIn this paper we study the supersingular locus of the reduction modulopof the Shimura variety for GU(1,s) in the case of an inert primep. Using Dieudonné theory we define a stratification of the corresponding moduli space ofp-divisible groups. We describe the incidence relation of this stratification in terms of the Bruhat–Tits building of a unitary group.In the case of GU(1, 2), we show that the supersingular locus is equidimensional of dimension 1 and is of complete intersection. We give an explicit description of the irreducible components and their intersection behaviour.
Mild and Efficient One‐Pot Curtius Rearrangement: Preparation of

N

‐
tert
‐Butyl Adamantanyl‐1‐Yl‐Carbamate
Authors: Leogane Olivier , Lebel Hélène 
Published: January 2010

Abstract

N‐tert‐Butyl adamantan‐1‐yl‐carbamate

Sodium azide

Adamantine‐1‐carboxylic acid

Tetra‐
n‐
butyl ammonium bromide

Zinc triflate

Di‐
tert‐
butyl dicarbonate
Epidemiology of holoprosencephaly: Prevalence and risk factors
Authors: Orioli Iêda M. , Castilla Eduardo E. 
Published: January 2010

AbstractThe wide variation in cerebral and facial phenotypes and the recognized etiologic heterogeneity of holoprosencephaly (HPE) contribute to the observed inter‐study heterogeneity. High lethality during the early stages of embryonic and fetal development makes HPE detection age dependent. By reviewing 21 HPE epidemiologic articles, the observed prevalence rate differences can be largely explained by the pregnancy outcome status of the studied cohort: livebirth, stillbirth, and terminations of pregnancy (TOPs): lower than 1 per 10,000 when live and still births were included, higher when TOPs were included, and between 40 and 50 per 10,000 in two classical Japanese studies on aborted embryos. The increasing secular trend observed in some studies probably resulted from an increasing use of prenatal sonography. Ethnic variations in birth prevalence rates (BPRs) could occur in HPE, but the available data are not very convincing. Higher BPRs were generally observed in the less favored minorities (Blacks, Hispanics, Pakistanis), suggesting a bias caused by a lower prenatal detection rate of HPE, and consequently less TOPs. Severe ear defects, as well as microstomia, were part of the spectrum of HPE. Non‐craniofacial anomalies, more frequently associated with HPE than expected, were genital anomalies (24%), postaxial polydactyly (8%), vertebral defects (5%), limb reduction defects (4%), and transposition of great arteries (4%). The variable female predominance, found in different HPE studies, could also depend on the proportion of early conceptions in each study sample, as males are more likely to be lost through spontaneous abortions. © 2010 Wiley‐Liss, Inc.
Holoprosencephaly and craniosynostosis: A report of two siblings and review of the literature
Authors: Raam Manu S. , Solomon Benjamin D. , Shalev Stavit A. , Muenke Maximilian 
Published: January 2010

AbstractHoloprosencephaly (HPE) and craniosynostosis are separate conditions that have occasionally been observed to occur simultaneously in the same patient. Here, we compile patients with both conditions who have been documented in the literature thus far; moreover, we report on two additional siblings who have not been previously described. We also compare the clinical features of these patients and discuss the previously hypothesized possibility of an independent association including both HPE and craniosynostosis. Published 2010 Wiley‐Liss, Inc.
Holoprosencephaly and agnathia spectrum: Presentation of two new patients and review of the literature
Authors: Kauvar Emily F. , Solomon Benjamin D. , Curry Cynthia J.R. , van Essen Anthonie J. , Janssen Nicole , Dutra Amalia , Roessler Erich , Muenke Maximilian 
Published: January 2010

AbstractHoloprosencephaly (HPE), the most common developmental disorder of the human forebrain, is occasionally associated with the spectrum of agnathia, or virtual absence of the mandible. This condition results in a constellation of structural cerebral and craniofacial abnormalities. Here we present two new patients and review 30 patients from the literature with HPE and variants of agnathia. The majority of these patients are female and have the most severe forms of HPE, with cyclopia present more frequently than is usually observed in cohorts of patients with HPE. Also, many patients have additional clinical findings not typical in patients with classic HPE, particularly situs abnormalities. Recent animal studies suggest that the association of HPE and agnathia may relate to alterations in signaling from forebrain and foregut endoderm organizing centers and subsequent first pharyngeal arch development, although present models are inadequate to explain all of the clinical findings of this enigmatic human syndrome. Further research is required to better elucidate the causal and pathogenic basis of this association. Published 2010 Wiley‐Liss, Inc.
Neuroimaging advances in holoprosencephaly: Refining the spectrum of the midline malformation
Authors: Hahn Jin S. , Barnes Patrick D. 
Published: January 2010

AbstractHoloprosencephaly (HPE) is a complex congenital brain malformation characterized by failure of the forebrain to bifurcate into two hemispheres, a process normally completed by the fifth week of gestation. Modern high‐resolution brain magnetic resonance imaging (MRI) has allowed detailed analysis of the cortical, white matter, and deep gray structural anomalies in HPE in living humans. This has led to better classification of types of HPE, identification of newer subtypes, and understanding of the pathogenesis. Currently, there are four generally accepted subtypes of HPE: alobar, semilobar, lobar, and middle interhemispheric variant. These subtypes are defined primarily by the degree and region of neocortical nonseparation. Rather than there being four discrete subtypes of HPE, we believe that there is a continuum of midline neocortical nonseparation resulting in a spectrum disorder. Many patients with HPE fall within the border zone between the neighboring subtypes. In addition, there are patients with very mild HPE, where the nonseparation is restricted to the preoptic (suprachiasmic) area. In addition to the neocortex, other midline structures such as the thalami, hypothalamic nuclei, and basal ganglia are often nonseparated in HPE. The cortical and subcortical involvements in HPE are thought to occur due to a disruption in the ventral patterning process during development. The severity of the abnormalities in these structures determines the severity of the neurodevelopmental outcome and associated sequelae. © 2010 Wiley‐Liss, Inc.
Holoprosencephaly flashcards: A summary for the clinician
Authors: Solomon Benjamin D. , Pineda‐Alvarez Daniel E. , Mercier Sandra , Raam Manu S. , Odent Sylvie , Muenke Maximilian 
Published: January 2010

AbstractThis material contains general information regarding the approach to patients with holoprosencephaly. For more detailed discussion, please refer to specific articles in this issue. Published 2010 Wiley‐Liss, Inc.