bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Role of Red Blood Cells in Cholesterol Accumulation and Atherosclerotic Plaque Instability: A Perspective on Atherosclerosis
Authors: Mohebbati Reza , Moghaddam Mohammad amin Momeni 
Published: February 2025

Abstract:
Atherosclerosis stands as the primary cause of CVD, characterized by the accumulation
of cholesterol deposits within macrophages in medium and large arteries. This deposition
promotes the proliferation of specific cell types within the arterial wall, gradually narrowing the
vessel lumen and impeding blood flow. Intra-plaque hemorrhages are recognized as critical
events in atherosclerotic plaques, leading to the deposition of red blood cells (RBCs) and the release
of hemoglobin (Hb). Approximately 40% of high-risk plaques exhibit intra-plaque hemorrhage.
Recent studies have demonstrated that intra-plaque hemorrhage is closely linked to plaque
progression and increased vulnerability, establishing it as a critical factor in the development of
acute clinical symptoms associated with atherosclerosis. The presence of RBC membranes within
atherosclerotic plaques contributes significantly to lipid accumulation, indicating a pivotal role
in plaque instability. Upon RBC degradation, cholesterol from both the membrane and its interior
can profoundly impact atherosclerotic plaque development. Considering that red blood cells
(RBCs) can contribute to the excretion of cholesterol through the hepatobiliary system alongside
HDL, and given that elevated cholesterol levels are a risk factor for the development and progression
of atherosclerotic plaques, RBCs may play a protective role in cardiovascular health.
However, when bleeding occurs within a plaque, RBCs that are trapped in the plaque environment,
an environment rich in oxidant compounds, can rupture. The cholesterol released from
these ruptured RBCs can significantly promote inflammatory reactions. This study aims to explore
the inconsistent role of RBCs and their cholesterol content in the progression of atherosclerotic
plaques.
Recent Trends in Physical Therapy Interventions and Neuromodulation Techniques to Improve Neurorehabilitation
Authors: Nath Patralika , Roy Barnana , Panigrahi Soumya Saswati , Islam Kamirul , Basak Asim Kumar 
Published: February 2025

Abstract:
Promoting neuroplasticity for better recovery and function restoration has lately become
the focus of rehabilitation techniques for individuals with neurologic disorders. A rapidly expanding
medical specialty, neuromodulation includes a broad variety of methods for activating particular
neurological pathways, such as Transcranial magnetic stimulation (TMS), Transcranial direct current
stimulation (tDCS), peripheral nerve stimulation, and SCS, among many others. Research on
the use of neuromodulation in the context of spinal cord injury (SCI) is limited, in contrast to the
abundance of literature on its potential benefits in chronic pain treatment. Combining exercise with
non-invasive neuromodulation improves recovery outcomes for some patient groups, according to
our research. While we mostly focus on the motor components of recovery, we do briefly mention
the non-motor effects of these disorders. The difficulties of applying ideas in clinical practice and
the gaps in the existing research are also brought to light. In order to better customize the individual
neuroplastic responses associated with each disease, we identify research gaps and propose routes
for future investigations. This review is useful for rehabilitation professionals and researchers since
it focuses on neuroplastic exercise treatments for specific illnesses and diagnoses. Few studies have
used long-term randomized-controlled trials, even though these approaches have great promise for
enhancing overall functionality and impairment levels. If these novel modalities may be therapeutically
employed to reduce pain, restore function, and improve the quality of life for individuals impacted,
then more study is required to support them.
Synthesis of Multi-Walled Carbon Nanotubes/CuO/Direct Blue 71 Nanocomposite: Characterization and Application in Uric Acid Sensing
Authors: Natarajan S.Karthik , Sridharan Gokul , Ganapathy Dhanraj , Sundramoorthy Ashok K. 
Published: February 2025

Background:
Uric acid is a key biomarker for diagnosing conditions, such as gout and
kidney disorders, highlighting the need for precise and efficient detection methods. Nanomaterialbased
biosensors, particularly those utilizing multi-walled carbon nanotubes (MWCNTs), copper
oxide (CuO), and direct blue 71 (DB), offer notable advantages due to their exceptional sensitivity
and selectivity.

Objective:
This study aims to design and evaluate an advanced electrochemical sensor for uric acid
detection, employing an MWCNTs/CuO/DB nanocomposite. By optimizing the component ratios,
the nanocomposite leverages synergistic interactions to achieve a superior performance.

Methods:
The MWCNTs/CuO/DB nanocomposite was synthesized and characterized using Field
Emission Scanning Electron Microscopy (FESEM), Energy-Dispersive X-ray Spectroscopy (EDX),
and elemental mapping to confirm its structural integrity and composition. Cyclic Voltammetry was
employed to assess the electrocatalytic behavior of the nanocomposite-modified glassy carbon electrode
(GCE). The sensor demonstrated a linear response to uric acid concentrations ranging from
100 to 1000 μM, with excellent electrocatalytic activity.

Results:
Material characterization revealed a uniform and well-dispersed structure of the MWCNTs,
CuO nanoparticles, and DB within the nanocomposite. Electrochemical analyses showed a concentration-
dependent response to uric acid, underscoring the sensitivity and reliability of the sensor for
biosensing applications.

Conclusion:
The MWCNTs/CuO/DB nanocomposite represents a highly promising electrochemical
platform for uric acid detection, combining an intricate structure, precise elemental composition,
and remarkable electrochemical performance. These findings highlight the potential of integrating
advanced nanomaterials into biosensing systems for clinical diagnostics and broader applications in
nanotechnology.
The Concept of Dignity in International Law
Authors: Szymaniec Piotr 
Published: February 2025

Summary
The first aims of the article is to trace the origins of the notion of human dignity in international law. It is emphasized that the concept of human dignity appeared in international law relatively late, in 1940s. and such concepts as “principle of humanity” or “laws of humanity”, used in the 19th century, are not identical with and do not even have to include human dignity. Moreover, a very different concept of “dignity of sovereign states” existed in international law from Vattel’s time until the 20th century. Nowadays, human dignity appears in international law as a value, legal principle and law. However, the right to dignity is less often explicitly mentioned in international law documents than the principle of human dignity. The minimum content of human dignity appears to include the recognition of the intrinsic value and moral autonomy of every human being.
The Instruments of Expeditiousness and Efficiency of the Arbitral Proceedings in the Rules of the International Arbitral Courts
Authors: Dobiáš Petr 
Published: February 2025

Summary
Currently, the emphasis in international commercial arbitration is on the speed and efficiency of arbitration proceedings in order for international commercial arbitration to maintain its position in resolving disputes in international trade. The article is based on the hypothesis that the need for permanent arbitral courts to remain competitive with state courts, whose proceedings are expedited at the national and EU level by legislation on summary proceedings, leads them to use instruments guaranteeing efficiency and speed in international arbitration. The subject of the analysis and comparison carried out in the article are recent amendments to the arbitration rules of selected permanent arbitration courts and a critical assessment of their applicability in legal practice. In particular, it compares the regulation of the preparation of the hearing of the dispute, consolidation of arbitration proceedings, on-line arbitration, remote oral hearing, and expedited proceedings.
The choice of a method of temporary hemostasis for injuries of the facial part of the skull resulting from road accidents
Authors: Masljakov V. V. , Barachevskij Yu. E. , Sidel›nikov S. A. , Pavlova O. N. , Pimenova A. A. , Polikarpov D A. , Polidanov M. A. , Sadovskov N. M. 
Published: February 2025

The purpose of the study. To determine the choice of the method of temporary hemostasis in patients with facial skull injuries resulting from road accidents.Materials and methods. The work is retrospective, the sample is continuous, based on the analysis of the results of 230 patients with facial skull injuries having both isolated and/or combined injuries sustained in road accidents in the Saratov region from 2010 to 2021. The average age of patients was 29±5 years (M±m). There were 159 men (69,1%) and 71 women (30,9%). Medical histories, outpatient cards, and accompanying sheets of the ambulance team were used as primary documentation. The study included all patients who were delivered by ambulance crews, who had open and closed, isolated, multiple and/or combined injuries to the facial skull resulting from road accidents, starting at the age of 15. Patients with combined injuries of the extremities, cervical spine, pelvis, as well as patients who were not delivered by ambulance crews were excluded. Isolated injuries were detected in 58,6% of the victims, combined and multiple — in 41,7% of people. In the majority of observations — 72,6% — medical care at the prehospital stage was provided by medical teams of emergency medical care, such assistance was provided by paramedic teams only in 27,4% of observations. The time of delivery of the wounded to the medical institution from the moment of injury was on average 27±8 minutes (M±m). At the time of admission, open injuries were registered in 34,4% of people, patients with closed injuries of the facial skull prevailed — 65,6% of the victims.Results. As a result of the study, it was found that all victims with such injuries can be conditionally divided into three groups, depending on the mechanism of injury: venous bleeding prevailed in the first group — in 6,9%, arterial bleeding was noted in 0,9% of cases, and capillary bleeding — in 3,9%. In the second group, bleeding was distributed as follows: capillary bleeding prevailed — in 13% of cases, arterial bleeding was noted in 2,6% of cases, and venous bleeding — in 4,3%. In the third group, capillary bleeding was detected in all 2.6% of cases. Based on this, the main method of temporary hemostasis was the imposition of a pressure bandage, which was applied in 23,5% of cases, in another 3,5% of cases, an anterior nasal tamponade was used to stop bleeding, in 7,4% of cases, a clamp was applied to stop bleeding. Of the total number of hemostases performed, as can be correctly characterized in 29,6% of cases, which was manifested by stopping bleeding. At the same time, in 4,8% of cases, the method of temporary hemostasis was not chosen correctly, which was manifested by continued bleeding at the time of delivery of the victim to a medical institution.
Antibacterial Activity of Bidara Arab Leaves (Ziziphus spina-christi L) Extract Against Gram-negative Anaerobic Subgingival Bacteria
Authors: Syahriel Dwis , Hervina Hervina , Sardi Ni Wayan Arni 
Published: February 2025

Background: Gram-negative anaerobic subgingival bacteria play an important role in the initiation and progression of periodontitis. The secondary metabolites contained in Bidara Arab leaves (Ziziphus spina-christi L) have potential to be antibacterial and inhibited the growth of pathogenic bacterial. The purposed of this study to evaluated the antibacterial activity of Bidara Leaves extract against gram-negative anaerobic subgingival bacteria. Method: Experimental laboratories using Mueller hinton agar to determine the antibacterial activity of Bidara leaves extract 40% and 60% against Porphyromonas gingivalis, Aggregatibacter ctinomycetemcomitans, and Fusobacterium nucleatum, with a comparison of the negative control group ethanol 96% and tetracycline as positive control. The production of extracts through maseration techniques and the subsequent phytochemical testing through tube reaction test. Result: The results of phytochemical analysis identified the presence of flavonoids, tannins, saponins, steroids. The inhibition test showed that the Bidara leaves extract exhibited strong inhibition and a concentration of 60% was more effective than 40% against Gram-negative anaerobic subgingival bacteria including Porphyromonas gingivalis, Aggregatibacter ctinomycetemcomitans, and Fusobacterium nucleatum. Conclusion: The Bidara Arab leaves (Ziziphus spina-christi L) extract at concentration 60% was more effective than 40% against gram-negative anaerobic bacteria
Analysis of Changes in Oral Microbiota for Interval of Post-Mortem Estimation: Review Article
Authors: Langit Ken Sekar , Prabowo Yoghi Bagus , Shifa Liftia Layyinatus 
Published: February 2025

Background: The microbiota change caused by the decomposition process after death can be used to determine the post-mortem interval. This condition is associated with changes in the oral microbiota. Oral microbiota can be used as an appropriate source for analysis without interfering with the corpse or breaking Indonesian law. This review will examine the changes in the oral microbiota to determine the time of death. Method: The literature search was carried out using PubMed, ScienceDirect, and Google Scholar, and the results were screened based on the inclusion and exclusion criteria. Result: The discussion was based on six literature reviews that met the criteria and subject matter of this review. Conclusion: The microbiota in the body contributes to the decomposition process after death. This condition allows it to be used as a reference for determining the postmortem interval. These changes, however, cannot be distinguished from the presence of factors such as temperature, pH, humidity, and an anaerobic environment. Consider these factors when analyzing post-mortem intervals using oral microbiota changes.
Oral Health Care and Aspiration Pneumonia
Authors: Salma Yasmin Hanifa , Murad Chrysanti , Megantara Imam 
Published: February 2025

Background: Oral health care is important to prevent aspiration pneumonia. Poor oral hygiene in elderly patients heightens the risk of aspiration pneumonia due to the growth of potential periodontopathogen bacteria. This literature review aims to describe the effect of oral health care on the incidence of pneumonia and/or the number of oral bacteria.Method: The literature search was conducted based on the PRISMA guideline with the PICO framework by utilizing electronic search engines in databases: PubMed, Cochrane's Library, and Google Scholar from March through May 2024. All articles to be reviewed were ‘’full text” published from 2014 to 2024. An eligibility assessment was conducted based on inclusion and exclusion criteria; thus, seven articles were selected.Result: Mechanical tooth and mouth cleaning, in addition to using mouthwash and moisturizing agents, effectively reduces the risk of aspiration pneumonia in the elderly.Conclusion: Oral health care with mechanical and pharmacological interventions are deemed appropriate to be given to elderly individuals to prevent aspiration pneumonia.
Género y vocación en el Trabajo Social
Authors: Pérez Castillo Estefanía , Rubio Guzmán Eva María 
Published: February 2025

Introducción: Este trabajo investiga si la elección profesional es una imposición social o una vocación intrínseca, destacando el papel del género en este proceso, especialmente en profesiones feminizadas como el Trabajo Social. Metodología: De enfoque cualitativa, mediante la realización de 10 entrevistas en profundidad a estudiantes y profesionales del trabajo social para captar su perspectiva sobre cómo el género afecta la selección y el desempeño profesional. Resultados: La investigación muestra que la socialización diferencial desde edades tempranas influye en las elecciones profesionales basadas en estereotipos de género. Además, en profesiones mayoritariamente femeninas, como el trabajo social, los hombres tienden a tener un mayor desarrollo profesional, resaltando las disparidades de género. Discusión: Este estudio corrobora junto a otros que las expectativas de género predisponen a las mujeres hacia profesiones de cuidado y a los hombres hacia trabajos con mayor reconocimiento social y nivel económico. Conclusiones: Promover la igualdad de género en el ámbito laboral es crucial para romper roles tradicionales y avanzar hacia una sociedad más inclusiva y equitativa que valore el potencial de todas las personas sin importar su género.
Análisis y clasificación de atributos de mantenibilidad del software: una revisión comparativa desde el estado del arte
Authors: Erazo Martínez Jennifer , Flórez Gómez Andrés , Pino Francisco J. 
Published: February 2025

Nowadays software maintenance is the most expensive stage in the life cycle of a software product. Identifying the attributes that influence software maintainability is an important aspect that will be useful when knowing the factors to be included during the development process in order to achieve a highly maintainable product. In this sense, this paper provides a comprehensive overview of the different maintainability attributes based on the literature, and proposes their classification taking into account the following items: (i) the maintainability sub-characteristics from the ISO/ IEC 25010 standard influenced by it, and (ii) the software development workflow of RUP (Rational Unified Process) in which it is presented. As a result of this research, a total of 18 attributes were obtained and classified, based on the criteria previously mentioned, which describe the different aspects to be considered when trying to develop a highly maintainable product. The maintainability attributes and the classification obtained in this research have been used to create a process reference model which supports the inclusion of maintainability sub-characteristics to the product during the software development process.
Estudio de la viabilidad del Lactobacillus casei en jugo de naranja (Citrus sinensis) adicionado con vitamina C, Calcio y oligofructosa1
Authors: Londoño Castaño María Cecilia , Lucas Aguirre Juan Carlos , Quintero Castaño Victor Dumar 
Published: February 2025

Valencia Orange was used to produce a juice enriched with probiotic bacteria (Lactobacillus casei). The optimal concentration of stabilizer was evaluated by performing a screening with three types of gums (xanthan, CMC, and pectin), evaluated using a factorial arrangement 33. Subsequently the microorganism at three different concentrations (0.4 -0.5 and 0.6 was added 6 Mc - Farland) and physiologically active compounds (calcium and vitamin C) 20% of the recommended daily value according to the resolution 333 of 2011 the ministry of social protection. The results showed that 0.02% pectin, CMC and Xanthan 0.015% 0.014% should be added. The analysis of the concentration of microorganisms during storage time shows that the initial concentration increased up to 7.21 * 109 CFU, and the pH remained constant from day 15 to 20 in 3.8.
Síntesis Digital Directa de Señales para Uso en Instrumentación Científica a Partir de un Generador de Ondas Programable
Authors: Espitia Javier , Velásquez Álvaro 
Published: February 2025

Devices based on direct digital synthesis (SDD) have become a very attractive tool for engineers and scientifics who develop electronic instrumentation, being each time more used than analogic systems for signal generation because them offer advantages in performance and ease of manipulation of the parameters of the signals. In this work we present the implementation of the SDD technique in order to generate arbitrary signals with the programmable waveform generator Agilent 33220A. By means of a macro developed in Visual Basic, which is executed from Excel, the data of arbitrary signals are sent to the generator through the general purpose bus interface (GPIB). As a particular application of the method, we present the digital direct synthesis of the control signal for the oscillations of a velocity transducer used in transmisión Mössbauer spectroscopy.
Akuntansi Pameran Seni Rupa (Kajian Pengembangan Ekonomi Kreatif Berbasis Seni Budaya Di Kota Banjarmasin)
Authors: Nikmah Nailiya , Julkawait  
Published: February 2025

Seni rupa merupakan salah satu bagian dari ekonomi kreatif berbasis seni dan budaya. Untuk menunjukkan hasil karya ciptanya, para pelaku seni bidang seni rupa memajang karyanya pada kegiatan yang bernama pameran. Pameran merupakan sebuah kegiatan yang diadakan untuk menarik masyarakat dari berbagai kalangan agar datang dan menikmati karya yang dipamerkan. Ditinjau dari sudut sebuah manajemen industri, pameran seni rupa dengan tujuan dan peran beragam pihak sesungguhnya memerlukan akuntansi sebagai salah satu komponen informatif dan diplomatis dalam pengambilan keputusan yang akuntabel dalam manajemen dalam hal ini manajemen pameran seni rupa. Jenis penelitian yang dilakukan adalah penelitian kualitatif. Penelitian dilakukan terhadap pelaku seni yang mengadakan pameran seni rupa di kota Banjarmasin. Hasil penelitian menyimpulkan bahwa pameran seni rupa di Banjarmasin memiliki potensi yang cukup bagus sebagai bagian dari pengembangan ekonomi kreatif namun masih memerlukan manajemen yang lebih serius terutama pada sisi akuntansinya.
Efektivitas Penggunaan Media YouTube dalam Pembelajaran Sistem Hybrid
Authors: Ariza Hidra 
Published: February 2025

The Covid-19 has an impact on accelerating the transformation of education in Indonesia. Starting from active online learning then developing into the implementation of hybrid learning. At this time, hybrid learning has become important to use due to the demands of developments in information and communication technology in all aspects of life, including in the world of education. The development of technology and information in the world of education has encouraged the emergence of innovative learning models which are useful as alternatives for solving the obstacles faced in traditional learning models. This hybrid learning system is seen as being able to support the concept of Independent Learning, Independent Campus. The use of a hybrid learning system at the tertiary level is a form of digital transformation in the world of higher education. Digital literacy is applied at the tertiary level in conjunction with the learning process using the hybrid learning method. One platform that can be used as a learning medium in this hybrid learning system is YouTube. YouTube was chosen as a learning medium because YouTube is easy to access and students can access learning materials on YouTube wherever and whenever they need. This research was conducted to see the effectiveness of using YouTube media in Hybrid system learning in the History of Islamic Education course. The results of the research that has been carried out is, YouTube media is effectively used as a learning medium for Islamic education history courses, this is proven by the result analysis that 74,33%. This means that most of the respondents agreed that YouTube media was effective in learning.