bluuebunny/crossref_metadata_2025_split huggingface dataset:
Peroral endoscopic myotomy for hypercontractile (Jackhammer) esophagus: A retrospective multicenter series with long‐term follow‐up
Authors: Albers David , Witt Mana , Pandolfino John E. , Rösch Thomas , Schachschal Guido , Beyna Torsten , Neuhaus Horst , Gerges Christian , Kandler Jennis , Allescher Hans‐Dieter , Martinek Jan , Repici Alessandro , Ebigbo Alanna , Messmann Helmut , Schumacher Brigitte , Werner Yuki B. 
Published: June 2024

AbstractIntroductionLong‐term outcome data are limited for non‐achalasia esophageal motility disorders treated by peroral endoscopy myotomy (POEM) as a separate group. We investigated a subset of symptomatic patients with hypercontractile esophagus (Jackhammer esophagus).MethodsForty two patients (mean age 60.9 years; 57% female, mean Eckardt score 6.2 ± 2.1) treated by primary peroral myotomy for symptomatic Jackhammer esophagus 2012–2018 in seven European centers were retrospectively analyzed; myotomy included the lower esophageal sphincter but did not extend more than 1 cm into the cardia in contrast to POEM for achalasia. Manometry data were re‐reviewed by an independent expert. The main outcome was the failure rate defined by retreatment or an Eckardt score >3 after at least two years following POEM.ResultsDespite 100% technical success (mean intervention time 107 ± 48.9 min, mean myotomy length 16.2 ± 3.7 cm), the 2‐year success rate was 64.3% in the entire group. In a subgroup analysis, POEM failure rates were significantly different between Jackhammer‐patients without (n = 22), and with esophagogastric junction outflow obstruction (EGJOO, n = 20) (13.6% % vs. 60%, p = 0.003) at a follow‐up of 46.5 ± 19.0 months. Adverse events occurred in nine cases (21.4%). 14 (33.3%) patients were retreated, two with surgical fundoplication due to reflux. Including retreatments, an improvement in symptom severity was found in 33 (78.6%) at the end of follow‐up (Eckardt score ≤3, mean Eckardt change 4.34, p < 0.001). EGJOO (p = 0.01) and frequency of hypercontractile swallows (p = 0.02) were predictors of POEM failure. The development of a pseudodiverticulum was observed in four cases within the subgroup of EGJOO.ConclusionsPatients with symptomatic Jackhammer without EGJOO benefit from POEM in long‐term follow‐up. Treatment of Jackhammer with EGJOO, however, remains challenging and probably requires full sphincter myotomy and future studies which should address the pathogenesis of this variant and alternative strategies.
A preliminary global investigation into potential impacts on successful captive breeding for two species of Rhyticeros hornbill
Authors: Groot Kees , Brereton James E. , King Catherine E. , Rose Paul 
Published: June 2024

AbstractAsian hornbills have limited ex situ breeding success, yet these species are some of the most threatened of birds, in need of managed breeding programs. To optimize breeding and increase the sustainability of such populations, it is necessary to assess and improve their husbandry and welfare. Evidence to improve reproduction can be gathered through global husbandry surveys. A survey was sent out to all European Association of Zoos and Aquaria and Association of Zoos and Aquarium holders of the wreathed hornbill (Rhyticeros undulatus) and Papuan hornbill (R. plicatus) to determine predictors for ex situ breeding success. This research found that pairs that have spent more years together (p = .016) and that adding additional proteins to the diet (p = .006) are two significant predictors of breeding success for wreathed‐ and Papuan hornbill pairs. This paper found a general trend that successful hornbill pairs prefer nest boxes that are situated outside (p = .054). The behaviors of calling to each other and sitting in close proximity showed a general trend and were observed more frequently in successful pairs and, therefore, could be good indicators of bonded pairs. We recommend that ex situ institutions allow their hornbill pairs time to form strong bonds, and that pair compatibility is monitored regularly to ensure that such interactions are positive and not consistently negative. An increase in the percentage of dietary proteins, prior and during the breeding season appears to stimulate pairs to breed. If the management and husbandry alterations presented in this study are implemented, the sustainability of Rhyticeros hornbill populations may be enhanced.
Symmetry of the left and right tibial plafond; a comparison of 75 distal tibia pairs
Authors: Verbakel Joy , Boot Miriam R. , van der Gaast Nynke , Dunning Hans , Bakker Max , Jaarsma Ruurd L. , Doornberg Job N. , Edwards Michael J. R. , van de Groes Sebastiaan A. W. , Hermans Erik 
Published: June 2024

Abstract
Purpose
Tibia plafond or pilon fractures present a high level of complexity, making their surgical management challenging. Three-Dimensional Virtual Planning (3DVP) can assist in preoperative planning to achieve optimal fracture reduction. This study aimed to assess the symmetry of the left and right tibial plafond and whether left–right mirroring can reliably be used.

Methods
Bilateral CT scans of the lower limbs of 75 patients without ankle problems or prior fractures of the lower limb were included. The CT images were segmented to create 3D surface models of the tibia. Subsequently, the left tibial models were mirrored and superimposed onto the right tibia models using a Coherent Point Drift surface matching algorithm. The tibias were then cut to create bone models of the distal tibia with a height of 30 mm, and correspondence points were established. The Euclidean distance was calculated between correspondence points and visualized in a boxplot and heatmaps. The articulating surface was selected as a region of interest.

Results
The median left–right difference was 0.57 mm (IQR, 0.38 – 0.85 mm) of the entire tibial plafond and 0.53 mm (IQR, 0.37 – 0.76 mm) of the articulating surface. The area with the greatest left–right differences were the medial malleoli and the anterior tubercle of the tibial plafond.

Conclusion
The tibial plafond exhibits a high degree of bilateral symmetry. Therefore, the mirrored unfractured tibial plafond may be used as a template to optimize preoperative surgical reduction using 3DVP techniques in patients with pilon fractures.
Properties of sandwich boards with a core made of bio-composite particleboard containing wood particles and walnut shells
Authors: Dukarska Dorota , Grześkowiak Wojciech , Kawalerczyk Jakub , Klucewicz Maciej , Florczak Maciej , Góral Błażej 
Published: June 2024

AbstractThe aim of the research was to investigate the possibility of producing bio-composite particleboard with a density reduced to 500–550 kg/m3, containing 25% and 50% of walnut shells. In addition, the study also concerned the possibility of using these materials in sandwich systems. Based on the results, it was found that partial replacement of wood particles with ground shells leads to a significant reduction in the strength of the boards bonded with urea-formaldehyde (UF) resin. However, the implementation of a hybrid gluing method consisting of gluing wood particles with UF resin and walnut shells with 4,4′-methylenediphenyl isocyanate (pMDI) caused a significant improvement in the strength of the boards, especially for the variant with the highest shells content. Despite that, the manufactured materials still do not meet the requirements for furniture boards. The next step of the research has shown that these boards can perform well as a core layer in the sandwich boards covered with high-strength HDF boards. Moreover, it was found that increasing the share of walnut shells positively affected the dimensional stability of the resultant boards (thickness swelling and water absorption). However, substitution of wood with shells accelerated the ignition and flameout times of the boards. It increased the heat release without significantly affecting the percentage loss of the boards’ mass during exposure to fire.
Muscle synergies for multidirectional isometric force generation during maintenance of upright standing posture
Authors: Monte Andrea , Benamati Anna , Pavan Agnese , d’Avella Andrea , Bertucco Matteo 
Published: June 2024

AbstractMuscle synergies are defined as coordinated recruitment of groups of muscles with specific activation balances and time profiles aimed at generating task-specific motor commands. While muscle synergies in postural control have been investigated primarily in reactive balance conditions, the neuromechanical contribution of muscle synergies during voluntary control of upright standing is still unclear. In this study, muscle synergies were investigated during the generation of isometric force at the trunk during the maintenance of standing posture. Participants were asked to maintain the steady-state upright standing posture while pulling forces of different magnitudes were applied at the level at the waist in eight horizontal directions. Muscle synergies were extracted by nonnegative matrix factorization from sixteen lower limb and trunk muscles. An average of 5-6 muscle synergies were sufficient to account for a wide variety of EMG waveforms associated with changes in the magnitude and direction of pulling forces. A cluster analysis partitioned the muscle synergies of the participants into a large group of clusters according to their similarity, indicating the use of a subjective combination of muscles to generate a multidirectional force vector in standing. Furthermore, we found a participant-specific distribution in the values of cosine directional tuning parameters of synergy amplitude coefficients, suggesting the existence of individual neuromechanical strategies to stabilize the whole-body posture. Our findings provide a starting point for the development of novel diagnostic tools to assess muscle coordination in postural control and lay the foundation for potential applications of muscle synergies in rehabilitation.
Diet of non-breeding leach’s storm-petrels (Hydrobates leucorhous) in the sub-polar frontal zone of the North Atlantic
Authors: Silva Mónica C. , Catry Paulo , Newton Jason , Nunes Vera L. , Wakefield Ewan D. 
Published: June 2024

AbstractIn order to understand the drivers of the distribution and abundance of pelagic seabirds it is necessary to know what they eat, yet there remains little detailed, geo-referenced information on the diets of pelagic seabird. In particular, due to sampling difficulties, information is lacking for non-breeding stages, smaller species, such as storm-petrels, and remote oceanic areas, which may include important diversity hotspots. In this study, we aimed to characterize the trophic ecology of Leach’s storm-petrels foraging in the vicinity of the North Atlantic Current and Evlanov Seamount Marine Protected Area using a combination of survey methods. On a cruise undertaken in June 2017 to characterize the distribution and ecology of seabirds in the region, nineteen Leach’s storm-petrels were caught, sampled and released unharmed. Regurgitations and faecal samples were collected, as well as blood and feather tissues for stable isotope analyses. Of the 12 males, 6 females and 1 unsexed bird, 84% were in active flight feather moult, suggesting they were non-breeders. Prey species, assayed via molecular metabarcoding, were dominated by mesopelagic fish, principally lanternfishes (Myctophidae) and hatchetfishes (Sternoptychidae), but also included cephalopods and crustaceans. Additionally, almost half of the birds had microplastics in their regurgitates. Stable isotopic ratios did not differ significantly between sexes. Our results, combined with those of previous studies, suggest that within the oceanic North Atlantic, Leach’s storm-petrels feed at a similar trophic level to much larger seabirds, targeting mesopelagic fishes that are a key component of the North Atlantic pelagic food web.
Evaluation of oral health in 148 patients with systemic sclerosis—data from a prospective interdisciplinary monocentric cohort
Authors: Pecher Ann-Christin , Günaydin Bahar , Finke Hannah , Henes Jörg 
Published: June 2024

AbstractIn daily rheumatology practice, systemic sclerosis is primarily regarded as a potentially life-threatening disease characterized by fibrosis of various organs. Therefore, other manifestations, such as orofacial involvement, are often not of primary concern. Furthermore, due to its rarity, the disease might not be well known by dentists, which contrasts with the increased risk of various problems in the oral cavity. Periodontitis in particular is a known risk factor for morbidity and mortality and is associated with various systemic diseases. The risk of periodontitis appears to be increased in patients with systemic sclerosis, but little is known about the gender-specific differences. This study aims to elucidate the health-conscious behaviour of patients, their dental care and the risk of periodontitis with regard to gender-specific differences. This descriptive study of the Interdisciplinary Centre of Rheumatic Diseases (INDIRA) in collaboration with the Department of Orthodontics at the University Hospital of Tuebingen, Germany, examined the data of 148 patients with systemic sclerosis with regard to their oral health using a questionnaire and evaluating the risk of periodontitis with the DG Paro self-assessment score in this cohort. Among the participating patients, 90% reported regular visits to the dentist and good dental care. Nevertheless, more than half of the patients had missing teeth and problems opening their mouths. Sicca symptoms in the oral cavity were also common (40%). The risk of periodontitis among female participants was high (around 60%), and even higher among male study participants (around 80%). Gingival bleeding as a surrogate parameter for periodontitis was associated with salivary flow and the modified Rodnan skin score (mRSS). Despite a high awareness of dental health, we observed a high risk of periodontitis, especially in male patients with systemic sclerosis. In addition, the association between xerostomia and missing teeth as well as gingival bleeding and mRSS may indicate an increased risk in patients with a more progressive disease. We would therefore recommend regular dental consultations and careful oral hygiene for patients with systemic sclerosis in addition to the—more organ-focused—regular examinations of patients.
Unklare Ursache einseitiger Erblindung bei normwertigen Entzündungsparametern
Authors: Müller Felix , Pfob Christian Helmut , Wahle Matthias 
Published: June 2024

ZusammenfassungEine 70-jährige Patientin wird wegen akuter einseitiger Erblindung des rechten Auges vorgestellt. Bei unauffälligem C‑reaktivem Protein (CRP) und Blutsenkungsgeschwindigkeit (BSG) wird ein nichtarteriitischer embolischer Verschluss angenommen. Die weitere Anamnese ergibt jedoch den Verdacht auf eine Großgefäßvaskulitis, welcher durch die folgende bildgebende Diagnostik bestätigt wird. Dieser seltene Fall einer Großgefäßvaskulitis bei normwertigen Entzündungsparametern betont die Bedeutung von Anamnese und gezielter Diagnostik.
Bioavailability of Australian pre-schooler iron intakes at specific eating occasions is low
Authors: Atkins Linda A. , McNaughton Sarah A. , Spence Alison C. , Evans Lenore J. , Leech Rebecca M. , Szymlek-Gay Ewa A. 
Published: June 2024

Abstract
Purpose
Poor bioavailability may contribute to iron deficiency among children in high-resource countries, but iron bioavailability of Australian pre-schooler diets is unknown. This study aimed to estimate the bioavailability of Australian pre-schooler iron intakes across the day and by eating occasions to identify optimal timing for intervention, by using five previously developed algorithms, and to estimate the proportion of children with intakes of absorbable iron below the requirements.

Methods
Dietary data of children aged 2 to < 6 y (n = 812) from the 2011–12 National Nutrition and Physical Activity Survey were collected via two 24-h recalls. Usual food and nutrient intakes were estimated via Multiple Source Method. Phytate, polyphenol, and heme iron values were sourced from international databases or the literature. Five previously published algorithms were applied to observed dietary data to estimate iron bioavailability and calculate the prevalence of children with intakes of absorbable iron below requirements.

Results
Pre-schooler daily iron bioavailability was low (2.7–10.5%) and corresponded to intakes of 0.18–0.75 mg/d of absorbable iron. The proportion of children with inadequate intakes of absorbable iron ranged between 32 and 98%. For all eating occasions, dinner offered iron of the greatest bioavailability (4.2–16.4%), while iron consumed at breakfast was of the lowest bioavailability (1.2–5.6%).

Conclusion
Future strategies are required to improve intakes of bioavailable iron for pre-schoolers to prevent the risk of deficiency. These strategies could include the encouragement of concomitant consumption of enhancers of iron absorption with iron-rich sources, particularly at breakfast.
Genetics of bilateral pediatric cataract in the Israeli and Palestinian populations
Authors: Yahalom Claudia , Anteby Irene , Hendler Karen , Harel Tamar , Eilat Avital , Macarov Michal 
Published: June 2024

Abstract
Purpose
Bilateral pediatric cataract (BPC) is one of the most common causes of childhood visual impairment and blindness worldwide. A significant percentage of pediatric cataracts are caused by genetic alterations. We aim to characterize the set of genes and variants that cause BPC in the Israeli and Palestinian populations and to assess genotype-phenotype correlation.

Methods
Retrospective study in a multidisciplinary center for visual impairment, located in a tertiary medical center. Medical charts of families who underwent genetic counseling because of BPC in a family member were reviewed. Clinical characteristics and genetic tests results were obtained from medical records of affected subjects.

Results
Twenty-two families (47 patients) underwent genetic counseling and completed genetic testing. Causative variants were identified in 18/22 (81.8%) of the families, including 3 novel variants. Genetic testing used included mainly panel for congenital cataracts and whole exome sequencing. Eleven families performed genetic testing with the intention of future pregnancy planning. Main causative genes identified were crystalline genes followed by transcription factor genes. BCOR gene variants were associated with persistent fetal vasculature (PFV) cataract in two of three families.

Conclusions
Combined molecular techniques are useful in identifying variants causing pediatric cataracts and showed a high detection rate in our population. BCOR gene variants might be associated with PFV type of cataracts. The study of pathogenic variants may aid in family planning and prevention of pediatric cataracts in future pregnancies. Additionally, in certain cases, it assists in diagnosing non-suspected syndromic types of pediatric cataracts.
Morning physical activity may be more beneficial for blood lipids than afternoon physical activity in older adults: a cross-sectional study
Authors: Kim Hyeon-Ki , Kimura Yuga , Takahashi Masaki , Nakaoka Takashi , Yamada Yosuke , Ono Rei , Shibata Shigenobu 
Published: June 2024

Abstract
Background
The effect of differences in daily physical activity patterns on blood lipids has not been determined. This study examines the effects of the differences in free-living daily physical activity patterns (amount and intensity) on blood lipid levels in older adults.

Methods
This cross-sectional study included 51 older participants (71.8 ± 0.6 years, men = 8, women = 43). A triaxial accelerometer was used to assess physical activity patterns. The time from awakening to bedtime for each participant was used for group classification based on the amount (number of steps) and intensity (moderate-to-vigorous physical activity, MVPA) of physical activity. The morning step group (M Step) was defined as those who took more steps in the morning, and the afternoon step group (A Step) was defined as those who took more steps in the afternoon. The same method was used for MVPA (morning MVPA: M MVPA; afternoon MVPA: A MVPA). Blood samples were collected at the start of the study to determine blood lipid levels.

Results
Number of steps taken showed a trend toward lower low-density lipoprotein cholesterol (LDL-C) levels in the M Step group compared with the A Step group. The LDL/high-density lipoprotein (HDL) ratio was significantly lower in the M Step group than the A Step group (p < 0.05). The M MVPA group also had higher HDL-C levels and significantly lower LDL/HDL ratios than the A MVPA group (p < 0.05).

Conclusions
These results suggest that compared with afternoon physical activity, daily morning physical activity (amount and intensity) is more effective in improving blood lipid levels.
Optimal trade execution under small market impact and portfolio liquidation with semimartingale strategies
Authors: Horst Ulrich , Kivman Evgueni 
Published: June 2024

AbstractWe consider an optimal liquidation problem with instantaneous price impact and stochastic resilience for small instantaneous impact factors. Within our modelling framework, the optimal portfolio process converges to the solution of an optimal liquidation problem with general semimartingale controls when the instantaneous impact factor converges to zero. Our results provide a unified framework within which to embed the two most commonly used modelling frameworks in the liquidation literature and provide a foundation for the use of semimartingale liquidation strategies and the use of portfolio processes of unbounded variation. Our convergence results are based on novel convergence results for BSDEs with singular terminal conditions and novel representation results of BSDEs in terms of uniformly continuous functions of forward processes.
Non-numerical weakly relational domains
Authors: Seidl Helmut , Erhard Julian , Tilscher Sarah , Schwarz Michael 
Published: June 2024

AbstractThe weakly relational domain of Octagons offers a decent compromise between precision and efficiency for numerical properties. Here, we are concerned with the construction of non-numerical relational domains. We provide a general construction of weakly relational domains, which we exemplify with an extension of constant propagation by disjunctions. Since for the resulting domain of 2-disjunctive formulas satisfiability is NP-complete, we provide a general construction for a further, more abstract, weakly relational domain where the abstract operations of restriction and least upper bound can be efficiently implemented. In the second step, we consider a relational domain that tracks conjunctions of inequalities between variables, and between variables and constants for arbitrary partial orders of values. Examples are sub(multi)sets, as well as prefix, substring or scattered substring orderings on strings. When the partial order is a lattice, we provide precise polynomial algorithms for satisfiability, restriction, and the best abstraction of disjunction. Complementary to the constructions for lattices, we find that, in general, satisfiability of conjunctions is NP-complete. We therefore again provide polynomial abstract versions of restriction, conjunction, and join. By using our generic constructions, these domains are extended to weakly relational domains that additionally track disjunctions. For all our domains, we indicate how abstract transformers for assignments and guards can be constructed.