bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Modified Dugoff Tire Model for Combined-slip Forces
Authors: Ding Nenggen , Taheri Saied 
Published: September 2010

Abstract
Easy-to-use tire models for vehicle dynamics have been persistently studied for such applications as control design and model-based on-line estimation. This paper proposes a modified combined-slip tire model based on Dugoff tire. The proposed model takes emphasis on less time consumption for calculation and uses a minimum set of parameters to express tire forces. Modification of Dugoff tire model is made on two aspects: one is taking different tire/road friction coefficients for different magnitudes of slip and the other is employing the concept of friction ellipse. The proposed model is evaluated by comparison with the LuGre tire model. Although there are some discrepancies between the two models, the proposed combined-slip model is generally acceptable due to its simplicity and easiness to use. Extracting parameters from the coefficients of a Magic Formula tire model based on measured tire data, the proposed model is further evaluated by conducting a double lane change maneuver, and simulation results show that the trajectory using the proposed tire model is closer to that using the Magic Formula tire model than Dugoff tire model.
RXRA introne polymorphism and ABO blood groups in chronic heart failure
Authors: Pavkova Goldbergova Monika , Spinarova Lenka , Spinar Jindrich , Vítovec Jiri , Parenica Jiri , Poloczek Martin , Vasku Anna 
Published: September 2010

Abstract
Retinoic X receptor alpha (RXRA), a member of nuclear receptor superfamily, plays a key role in development, metabolism, glucose homeostasis, and intestinal cholesterol balance. The aim of this study was to examine an association of RXR alpha introne 5 A(39526)AA polymorphism and ABO blood groups with chronic heart failure (CHF) in the Czech population. A total of 238 patients with chronic heart failure and a control group of 246 subjects were included in the study. The RXR alpha gene polymorphism and ABO blood groups were detected by PCR and RFLP methods. Significant differences in distributions of RXRA A(39526)AA alleles and genotypes between CHF patients and controls were observed (Pg=0.03, Pa=0.02). The RXRA gene polymorphism differences of within blood group A between CHF patients and controls were highly significant in genotype distributions (Pg=0.002) and in allele frequency comparisons (Pa=0.0001). The prevalence of AA allele in CHF patients with A blood group was four-fold lower than in controls with the same blood group (OR=0.24; Pcorr=0.0001). A highly significant association of RXRA introne single-nucleotide insertion polymorphism and A blood group in chronic heart failure was observed. Our results suggest close linkage between RXRA A(39526)AA polymorphism and ABO blood groups.
American College of Rheumatology hybrid analysis of certolizumab pegol plus methotrexate in patients with active rheumatoid arthritis: Data from a 52‐week phase III trial
Authors: van Vollenhoven R. F. , Felson D. , Strand V. , Weinblatt M. E. , Luijtens K. , Keystone E. C. 
Published: August 2010

AbstractObjectiveThe American College of Rheumatology (ACR) hybrid (a modified mean percent response to treatment) was officially recommended by the ACR as a revision to 20%, 50%, and 70% response criteria (ACR20/50/70) scores, but has not been tested in clinical trials. We performed a post hoc analysis of a phase III study of certolizumab pegol (Rheumatoid Arthritis Prevention of Structural Damage 1 [RAPID 1]) using the ACR hybrid.MethodsPatients with active rheumatoid arthritis were randomized to certolizumab pegol (200 mg or 400 mg every other week) plus methotrexate or placebo plus methotrexate. ACR hybrid scores were compared with ACR20/50/70 outcomes.ResultsDifferences between active treatment and placebo were significant throughout the study using the ACR20 and ACR hybrid outcomes. In the certolizumab pegol 200 mg group, the median ACR hybrid score at week 52 (last observation carried forward) was 49.99. A total of 258 (65.8%) of 392 and 172 (43.9%) of 392 patients had ACR20 and ACR50 responses, respectively. An additional 55 patients (14.0%) and 59 patients (15.1%) had mean improvements in ACR core measures of ≥20% and ≥50%, respectively, and therefore had positive ACR hybrid scores, despite lacking ACR20 and ACR50 responses, respectively. In the placebo group, median ACR hybrid scores were <10 at most time points; unlike other measures, the ACR hybrid measure indicated worsening scores for many patients.ConclusionACR hybrid analysis had greater sensitivity than traditional ACR20/50/70 criteria, demonstrating improvements in ACR20 nonresponders treated with certolizumab pegol. Negligible benefit was observed with placebo using ACR hybrid analysis.
Capture basin approximation using interval analysis
Authors: Lhommeau M. , Jaulin L. , Hardouin L. 
Published: August 2010

AbstractThis paper proposes a new approach for computing the capture basin C of a target T. The capture basin corresponds to the set of initial state vectors such that the target could be reached in finite time via an appropriate control input, before possibly leaving the target. Whereas classical capture basin characterization does not provide any guarantee on the set of state vectors that belong to the capture basin, interval analysis and guaranteed numerical integration allow us to avoid any indetermination. We present an algorithm that is able to provide guaranteed approximation of the inner C− and the outer C+ of the capture basin, such that C−⊆C⊂C+. In order to illustrate the principle and the efficiency of the approach, a testcase on the ‘car on the hill’ problem is provided. Copyright © 2010 John Wiley & Sons, Ltd.
Engineering Homochiral Metal‐Organic Frameworks for Heterogeneous Asymmetric Catalysis and Enantioselective Separation
Authors: Liu Yan , Xuan Weimin , Cui Yong 
Published: August 2010

AbstractOwing to the potential applications in technological areas such as gas storage, catalysis, separation, sensing and nonlinear optics, tremendous efforts have been devoted to the development of porous metal‐organic frameworks (MOFs) over the past ten years. Homochiral porous MOFs are particularly attractive candidates as heterogeneous asymmetric catalysts and enantioselective adsorbents and separators for production of optically active organic compounds due to the lack of homochiral inorganic porous materials such as zeolites. In this review, we summarize the recent research progress in homochiral MOF materials, including their synthetic strategy, distinctive structural features and latest advances in asymmetric heterogeneous catalysis and enantioselective separation.
Interfacial Rheology Through Microfluidics
Authors: Martin Jeffrey D. , Marhefka Joie N. , Migler Kalman B. , Hudson Steven D. 
Published: August 2010

AbstractThe bulk properties and structural characteristics of emulsions arise substantially from their interfacial rheology, which depends strongly on surfactant mass transfer and its coupling to flow. Typical methods used to measure such properties often employ simpler flows and larger drops than those encountered in typical processing applications. Mass transfer mechanisms are governed by droplet size; therefore experimentation at length scales typical of those encountered in applications is desired. Utilizing a microfluidic approach allows high‐throughput experimentation at relevant length scales and with adjustable flow dynamics. Using a microfluidic device that facilitates the measurement of interfacial tension in two‐phase droplet flows, particle tracers are also used to determine the droplet internal circulation velocity as a measure of interfacial mobility. Combining these measurements in a single device, the coupling between interfacial tension, interfacial retardation, and surfactant mass transfer is explored and mass transfer coefficients and interfacial mobility are measured for a two‐phase system containing a diffusing surfactant. Such a device is also used to probe the deformability of elastic capsules and viscoelastic biological cells.
Craniosynostosis in pycnodysostosis: Broadening the spectrum of the cranial flat bone abnormalities
Authors: Bertola Débora , Amaral Cassio , Kim Chong , Albano Lilian , Aguena Meire , Passos‐Bueno Maria Rita 
Published: September 2010

AbstractPycnodysostosis is a rare autosomal recessive skeletal dysplasia caused by the absence of active cathepsin K, which is a lysosomal cysteine protease that plays a role in degrading the organic matrix of bones, acting in bone resorption and bone remodeling. The disease is primarily characterized by osteosclerosis, bone fragility, short stature, acro‐osteolysis, and delayed closure of the cranial sutures. A differing feature, cranial synostosis, has occasionally been described in this disorder. We reviewed six unrelated patients with pycnodysostosis (mean age of 10 years and 4 months) in order to evaluate the presence of craniosynostosis. In addition to the typical findings of the condition, they all presented premature fusion of the coronal suture. Although none of them showed signs of cranial hypertension, one patient had had the craniosynostosis surgically corrected previously. These data suggest that the cranial sutures in pycnodysostosis can display contradictory features: wide cranial sutures, which are commonly described, and craniosynostosis. The clinical impact of this latter finding still remains to be elucidated. Further studies are necessary to address more precisely the role of cathepsin K in suture patency. © 2010 Wiley‐Liss, Inc.
Further characterization of microdeletion syndrome involving 2p15‐p16.1
Authors: Félix Têmis Maria , Petrin Aline Lourenço , Sanseverino Maria Teresa Vieira , Murray Jeffrey C. 
Published: August 2010

AbstractWe report on a patient presenting with cognitive delay, prenatal and postnatal growth deficiency, microcephaly, ptosis of eyelids, high and broad nasal root, and camptodactyly. Analysis of a dense whole genome single‐nucleotide polymorphism (SNP) array showed a de novo 3.35 Mb deletion on 2p15‐p16.1. In order to study the parental origin of the deletion we analyzed selected SNPs in the deleted area in the proband and her parents showing Mendelian incompatibilities suggesting a de novo deletion on the chromosome of paternal origin. Based on the five cases described previously in the literature, we have narrowed the critical region responsible for the 2p15‐p16.1 microdeletion syndrome phenotype. The critical region does not include the VRK2 gene that had been speculated to have a role in cortical dysplasia. However, the association of the VRK2 gene with cortical dysplasia remains to be determined, as MRI imaging of the brain and gene content of the 2p15‐16 deletion becomes established in more patients. © 2010 Wiley‐Liss, Inc.
Evidence for a recurrent microdeletion at chromosome 16p11.2 associated with congenital anomalies of the kidney and urinary tract (CAKUT) and Hirschsprung disease
Authors: Sampson Matthew G. , Coughlin Curtis R. , Kaplan Paige , Conlin Laura K. , Meyers Kevin E.C. , Zackai Elaine H. , Spinner Nancy B. , Copelovitch Lawrence 
Published: August 2010

AbstractCongenital Anomalies of the Kidney and Urinary Tract can be associated with Hirschsprung disease. We report on three children with a similar 16p11.2 microdeletion with a spectrum of clinical anomalies consisting of congenital anomalies of the kidney and urinary tract in two patients (Patients 1 and 2) and Hirschsprung disease in two patients (Patients 1 and 3), leading us to hypothesize that a gene in this region is associated with these phenotypes. Patient 1 presented with left renal agenesis, grade‐IV vesicoureteral reflux, and Hirschsprung disease, Patient 2 with left renal agenesis, chronic kidney disease, chronic constipation, seizures, and developmental delay, and Patient 3 with Hirschsprung disease and normal kidneys. Genome‐wide microarray analysis demonstrated overlapping microdeletions within 16p11.2. The shortest region of overlap in the three patients contained only eight genes, including the SH2 domain‐containing binding protein 1 (SH2B1), an adaptor protein which has been implicated in enhancement of the tyrosine kinase activity of RET, whose role in developmental disease of the kidney and enteric enervation is well established. Our findings suggest that 16p11.2 deletions are associated with abnormalities of renal and enteric development and we hypothesize that deletion of SH2B1 may account for the observed phenotype. © 2010 Wiley‐Liss, Inc.
Atypical presentations and specific genotypes are associated with a delay in diagnosis in females with Rett syndrome
Authors: Fehr Stephanie , Downs Jenny , Bebbington Ami , Leonard Helen 
Published: September 2010

AbstractThere is often delay between onset of Rett syndrome symptoms and its diagnosis, possibly related to symptom presentation or socio‐demographic factors. We hypothesized that girls with an atypical presentation or whose family had a lower socio‐economic status would receive a later diagnosis. Female subjects with a confirmed diagnosis of Rett syndrome were sourced from the Australian Rett Syndrome and InterRett Databases. Variables analyzed included timing and development of symptoms;MECP2mutation type; parental occupation and education; maternal age and birth order. Residential location and socio‐economic status were also analyzed for the Australian cases. Linear regression was used to determine relationships between these factors and age at diagnosis. A total of 909 cases were included. An older age of diagnosis was associated with later loss of hand function and speech, later onset of hand stereotypies and the presence of the p.R133C or p.R294XMECP2mutation. Socio‐economic factors did not predict age of diagnosis for Australian families. For families participating in the InterRett database, a younger age of diagnosis was associated with higher levels of parental education or occupation. A clinical picture consistent with the classic presentation of Rett syndrome is associated with an earlier diagnosis. Clinicians need to be alerted to the variable presentation of Rett syndrome including the milder phenotypes of cases with the p.R133C or p.R294X mutation. Educational resources to assist this understanding including guidance on when to request genetic testing could be useful to streamline the process of diagnosis in Rett syndrome. © 2010 Wiley‐Liss, Inc.
Synthesis, characterization and anti‐microbial studies of cadmium(II) compounds containing 3,10‐C‐meso‐Me8[14]aneC. Crystal and molecular structure of cis‐[CdLC(NO3)](NO3)
Authors: Roy Tapashi G. , Hazari Saroj K. S. , Barua Kanak K. , Anwar Nurul , Zukerman‐Schpector Julio , Tiekink Edward R. T. 
Published: August 2010

AbstractOne isomeric ligand, LC, among three isomers of 3,10‐C‐meso‐3,5,7,7,10,12,14,14‐octamethyl‐1,4,8,11‐tetraazacyclotet‐radecanes (LA, LB and LC, differing in the orientation of methyl groups on the chiral carbon atoms), on reaction with Cd(NO3)2, CdCl2 and CdI2 produces octahedral cis‐mononitrato nitrate, trans‐dichloro and trans‐diiodo cadmium(II) compounds of formulae cis‐[CdLC(NO3)](NO3), trans‐[CdLCCl2] and trans‐[CdLCI2], respectively. The cis octahedral compound undergoes substitution reactions with KSCN, NaClO4 and KBr to form the trans‐substitution products, trans‐[CdLC(NCS)2], trans‐[CdLC(ClO4)2] and trans‐[CdLCBr2], respectively, whereby the bidentate NO3− ligand is replaced by two monodentate ligands that occupy axial positions. All compounds were characterized on the basis of analytical, spectroscopic, conductometric and magnetochemical data. The crystal structure of cis‐CdLC(NO3)](NO3) was determined by X‐ray crystallography and showed the cadmium centre to exist within a cis‐N4O2 donor set that defined a distorted octahedral geometry. Non‐systematic variations in the CdO and CdN bond distances were correlated with significant hydrogen bonding interactions operating in the crystal structure. The latter interactions led to the formation of supramolecular two‐dimensional arrays. The anti‐fungal and anti‐bacterial activities of these compounds were studied against some phytopathogenic fungi and bacteria. Coordination of LC by cadmium resulted in more effective anti‐microbial agents; no significant dependence upon the nature of the counter‐ion was detected. Copyright © 2010 John Wiley & Sons, Ltd.
Antituberculosis, antifungal and thermal activity of mixed ligand transition metal complexes
Authors: Kharadi G. J. , Patel J. R. , Dholakiya B. Z. 
Published: August 2010

AbstractMixed‐ligand complexes of the type [M(CQ)(Ph)(OH)(H2O)], where M = Cu(II), Ni(II), Co(II) and Mn(II), have been investigated. Furthermore, there has been some additional work investigating the effect of metal ions on biological activity. Aiming to obtain novel transition metal complexes that exhibit biological activity, we have synthesized mixed ligand complexes using clioquinol (5‐chloro‐7‐iodo‐8‐hydroxyquinoline) and 1,10‐phenanthroline as ligands. The compounds were characterized using IR, FAB mass spectroscopy, elemental analyses, electronic spectra, magnetic measurements and gravimetric analyses. The kinetic parameters such as order of reaction, the energy of activation, the pre‐exponential factor, activation entropy, activation enthalpy and free energy of activation have been reported. The complexes show antituberculosis and antifungal (minimal inhibitory concentration) activities. Copyright © 2010 John Wiley & Sons, Ltd.
Synergistic inhibition effect of polyethylene glycol–polyvinyl pyrrolidone blends for mild steel corrosion in sulphuric acid medium
Authors: Umoren Saviour A. 
Published: August 2010

AbstractThe corrosion inhibition of mild steel in sulphuric acid solution in the presence of polyethylene glycol (PEG), polyvinyl pyrrolidone (PVP), and their blends was investigated using weight loss and hydrogen evolution techniques at temperature range of 30–60°C. It was found that inhibition efficiency (η%) increases with increase in concentration of the homopolymers and decreases with increase in temperature. Inhibition efficiency was found to be synergistically enhanced on blending the two polymers with highest inhibition efficiency obtained for (PEG : PVP) blending ratio of 1 : 3. The experimental data obtained fitted well into Temkin adsorption isotherm model. Physical adsorption mechanism is proposed from the trend of inhibition efficiency with temperature. The proposed mechanism is also corroborated by kinetic and thermodynamic parameters obtained. © 2010 Wiley Periodicals, Inc. J Appl Polym Sci, 2011
Effect of irradiation on mechanical and structural properties of ethylene vinyl acetate copolymers hollow fibers
Authors: Khodkar F. , Ebrahimi N. Golshan 
Published: August 2010

AbstractEffect of irradiation on mechanical and structural properties of ethylene vinyl acetate copolymers (EVA) hollow fibers was studied by the tests such as determination of gel content, density, tensile, FTIR, SEM, and DMA. These effects were discussed based on dose and irradiation environment. The results of gel content depicted that irradiated EVA in ambient conditions had tendency to chain scission while the crosslinking overcame in irradiated samples under nitrogen. Density insignificantly enhanced with irradiation dose. In tensile test, irradiation induced increase in tensile strength and decrease in elongation at break (especially in samples irradiated in nitrogen). Also, changing in layer orientation could be observed by SEM images. In addition, irradiation caused altering peak intensity in FTIR spectrum. DMA results demonstrated that irradiation broaden the elastic zone. Totally, irradiation enhances features especially in irradiated EVA18 in nitrogen. Since, according to stabilization of induced deformation and improvement of mechanical properties (that created by radiation), the irradiated samples can be used in different applications. © 2010 Wiley Periodicals, Inc. J Appl Polym Sci, 2011
Investigation on isothermal crystallization, melting behaviors, and spherulitic morphologies of multiblock copolymers containing poly(butylene succinate) and poly(1,2‐propylene succinate)
Authors: Zheng Liuchun , Li Chuncheng , Guan Guohu , Zhang Dong , Xiao Yaonan , Wang Dujin 
Published: August 2010

AbstractIn this article, isothermal crystallization, melting behaviors, and spherulitic morphologies of high‐impact multiblock copolymers, comprising of PBS as hard segment and poly(1,2‐propylene succinate) (PPSu) as soft segment with hexamethylene diisocyanate as a chain extender, were investigated. The results from differential scanning calorimetry (DSC) suggest that the two segments of multiblock copolymers are miscible in amorphous region. The crystallization kinetics were analyzed by the Avrami equation. The effect of PBS segment length as well as the introduction of PPSu segment on the crystallization kinetics and melting bebaviors of block copolymers was studied. Both crystallization rate (G) and spherulitic growth rate (g) are markedly increased with the increase of PBS segment length or decreased with the incorporation of PPSu segment. All the multiblock copolymers show the multiple melting behaviors, whose position and area depend on PBS segment length and the presence of PPSu segment. The melting peaks shift to higher temperature region with increasing PBS segment length. Spherulitic morphologies of the multiblock copolymers after being isothermally crystallized were examined by polarized optical microscopy. It is the first time to investigate the effect of one segment length on crystallization bebavior of block copolymers based on a fixed weight ratio systematically. © 2010 Wiley Periodicals, Inc. J Appl Polym Sci, 2011
Segmented poly(urethane‐urea) elastomers based on polycaprolactone: Structure and properties
Authors: May‐Hernández L. , Hernández‐Sánchez F. , Gomez‐Ribelles J. L. , Sabater‐i Serra R. 
Published: August 2010

AbstractA series of segmented poly(urethane‐urea) polymers have been synthesized varying the hard segments content, based on the combination of polycaprolactone diol and aliphatic diisocyanate (Bis(4‐isocyanatocyclohexyl)methane), using diamine (1,4‐Butylenediamine) as the chain extender. The microstructure and properties of the material highly depend on the hard segments content (from 14 to 40%). These PUUs with hard segment content above 23% have elastomeric behaviors that allow high recoverable deformation. The chemical structure and hydrogen bonding interactions were studied using FTIR and atomic force microscopy, which revealed phase separation that was also confirmed by DSC, dynamic‐mechanical, and dielectric spectroscopy. © 2010 Wiley Periodicals, Inc. J Appl Polym Sci, 2011