bluuebunny/crossref_metadata_2025_split huggingface dataset:
Warfarin without Therapeutic Monitoring is a Rodenticide, but this Time it Kills the Patient: A Warfarin Toxicity Case Report
Authors: Mirzahosseini Hossein Karballaei , Moradpour Nioosha , Mazhin Ehsan Yousefi , Najafi Atabak , Mojtahedzadeh Amirmahdi , Mojtahedzadeh Mojtaba 
Published: February 2025

According to the American Association of Poison Control Centers (AAPCC), 761 single exposures to the pharmaceutical warfarin were reported in 2021, accounting for more than 10 percent of anticoagulant cases. The cost and mortality caused by warfarin toxicity are very high and usually incurable and fatal. The most important action in the field of warfarin toxicity is to prevent its occurrence. To emphasize how warfarin toxicity occurs, a case is introduced in this regard. A 61-year-old man is found unconscious with a seizure on the street and transported to the hospital by Emergency Medical Services (EMS). In the emergency car, he received a diazepam injection for generalized seizures. His vital signs in the postictal state were as follows: blood pressure 82/44 mmHg, pulse rate 91 bpm, and oxygen saturation (SaO2) 93%. His past medical history includes an ischemic stroke and a myocardial infarction 12 years ago. He underwent Mitral valve repair 11 years ago and a mechanical-type Mitral valve replacement 2 years ago. After undergoing mitral valve replacement surgery, he continued taking warfarin and aspirin for 2 years without consulting a cardiologist or undergoing PT and INR tests. As a result, he suffered a massive intracerebral hemorrhage when his INR level rose above 6. It's important to note that he has no history of depression or suicide attempts. After experiencing decreased consciousness and seizures, he was quickly intubated. A brain CT scan revealed extensive evidence of intracerebral hemorrhage, and he was then transferred to the operating room for craniotomy. To manage the bleeding and because Prothrombin complex concentrate (PCC) was not available, the patient received two grams of fibrinogen, two units of Fresh Frozen Plasma (FFP), 10 mg of vitamin K, and one unit of Packed Red Blood Cells. Unfortunately, after a month-long stay in the ICU, the patient passed away as a result of Ventilator-associated pneumonia (VAP) and sepsis.
Pernikahan Merariq Sebagai Bentuk Hubungan Sosial Dalam Mempertahankan Nilia-Nilai Maskulinitas Suku Sasak [Merariq Marriage as a Form of Social Relations in Maintaining Sasak Tribe Masculinity Values]
Authors: Angelique Jesslyn 
Published: February 2025

Indonesia yang terbentang dari sabang sampai merauke memiliki keragaman suku budaya yang sangat banyak. Salah satu budaya yang sampai sekarang masih ada dan dijalankan adalah budaya Kawin Lari atau Merariq oleh suku Sasak di desa Sade, Lombok. Proses Merariq sendiri berlangsung secara panjang dan terdapat peran masing-masing dari setiap pelaku Merariq. Jika ditelaah secara lebih mendalam, laki-laki memainkan peran yang vital dalam melaksanakan kegiatan ini, didorong dengan nilai-nilai maskulinitas yang dikonstruksi oleh desa Sade. Penelitian ini menggunakan pendekatan kualitatif dengan metode etnografi. Pengumpulan data penelitian dilakukan dengan data primer, yaitu wawancara dan observasi serta data sekunder berupa data lain dari jurnal, buku maupun sumber lain yang relevan dengan topik yang dibahas. Wawancara dilakukan kepada local guide, anggota local guide serta pelaku Merariq sendiri. Hasil penelitian menunjukan bahwa Merariq digunakan sebagai sebuah bentuk hubungan sosial dalam mempertahankan nilai-nilai maskulinitas dan sampai sekarang keberadaannya terus ada seiring terus dilakukannya kegiatan Merariq. Kedudukan laki-laki yang mendominasi sendiri bukan menjadi sesuatu yang buruk melainkan bisa membantu mensukseskan kegiatan Merariq sendiri.

Indonesia, which stretches from Sabang to Merauke, has a great diversity of ethnic cultures. One culture that still exists and is practiced today is the Elopement or Merariq culture by the Sasak tribe in Sade village, Lombok. The Merariq process itself takes a long time and there is a role for each Merariq actor. If examined in more depth, men play a vital role in carrying out this activity, driven by the values of masculinity constructed by Sade village. This research uses a qualitative approach with ethnographic methods. Research data collection was carried out using primary data, namely interviews and observations as well as secondary data in the form of other data from journals, books and other sources relevant to the topic discussed. Interviews were conducted with local guides, local guide members and Merariq actors themselves. The research results show that Merariq is used as a form of social relationship in maintaining masculinity values and to this day its existence continues to exist as Merariq activities continue to be carried out. The dominating position of men in itself is not a bad thing but can help make Merariq's activities a success.
Potential of ethanol to reduce grapevine transpiration
Authors: Ait Kaci Neila , Quinquiry Beatrice , Diot Alice , Yobregat Olivier , Pellegrino Anne , Maury Pierre , Chervin Christian 
Published: February 2025

This study investigates whether ethanol (EtOH) modulates response to drought in grapevine, as demonstrated previously in Arabidopsis, rice and wheat. We ran a potted-cutting experiment with a progressive soil water deficit. Plants pre-treated with 250 mM EtOH solutions exhibited slower depletion of the fraction of transpirable soil water (FTSW), compared to controls. While 250 mM EtOH decreased transpiration in the early days, these EtOH pre-treated plants maintained higher leaf transpiration than controls after 10 days of soil water depletion. The FTSW threshold for the transpiration process was significantly higher in plants treated with 250 mM EtOH than in controls. These results suggest that EtOH may alter grapevine response to drought, leading to potential water savings in wine-growing regions prone to high water shortages, linked to climate change. This should encourage further testing under various vineyard conditions.
Assessing Risk in Long-Term CO2 Storage Under Uncertainty via Survival Analysis-Based Surrogates
Authors: Gurwicz A. , Chen J. , Gutman D. H. , Gildin E. 
Published: February 2025

Summary
Reservoir simulations for CO2 sequestration are computationally expensive because they rely on being run for large timescales. Shortened, cheaper simulation timelines prevent the observation of gas leakages that might occur over a longer duration. In the statistics community, the exclusion of these leakages is called censorship. We propose a fast simulator surrogate that captures these potentially unobservable long-term risks. The crux of our approach is survival analysis, a branch of statistics tailored to handle censored data.
Our proposed framework begins by sampling scenarios with varied injection and production rates from a number of geological and flow uncertainty realizations. The potentially censored time to gas leakage is recorded for each simulated scenario. We then leverage a variety of survival analysis methods, ranging from Kaplan-Meier to random survival forests, to create a computationally cheap, and highly interpretable, simulator surrogate. The surrogate can predict the risk of CO2 leakage in new scenarios for significantly shorter simulations than usual in carbon sequestration studies, or no new simulations at all. This eases the computational burden of centuries-long, expensive simulations.
To validate our methodology, we constructed an exploratory case study with a shortened monitoring window. The proposed framework is implemented within a compositional simulation model where CO2 is injected into a saline aquifer. To assess the risk of leakage and caprock integrity, we simulated scenarios where we inject CO2 for permanent storage using four injector wells, while five producer wells are used for pressure maintenance. This model is run for 2,000 days under varied permeability realizations to monitor CO2 breakthrough from the production wells. We then infer the occurrence of leakage in new scenarios and compare these results to full simulations via appropriate statistical metrics such as hypothesis testing, metrics tailored for the censored data context, and common prediction metrics. Initial results show that the proposed method predicts time to gas leakage with good accuracy without the need for any new simulations at all.
To the best of the authors’ knowledge, this is the first paper to approach the broader reservoir engineering for carbon capture area with survival analysis, a clear fit due to the presence of censored data coming from shortened simulations. Our unique, novel framework yields a simulator surrogate built with techniques never before seen in this context. Also, we fill the gap other approaches leave open by focusing on interpretability, a model quality that is paramount to decision-making under high uncertainty.
Downregulation of UDP-glucose 6-dehydrogenase predicts adverse prognosis in colorectal cancer and promotes tumorigenesis
Authors: Wang Mengyuan , Ge Zhiming , Fan Xianxian , Zhao Hongbo , Shi Zhenfu , Zhang Jiucun , Jin Li , Li Yan , Wang Jie , Zao Xiaobin , Yang Yun 
Published: February 2025

Abstract

Backgrounds: UDP-glucose 6-dehydrogenase (UGDH) is the key enzyme of glucuronic acid metabolism and a key mediator in several cancer developmental signaling pathways. However, the expression and function of UGDH in colorectal cancer (CRC) are unclear.
Method:Bioinformatics analysis was conducted to research the expression, diagnosis, prognosis, functional enrichment, genetic alterations, and immune characteristics of UGDH in CRC. The UGDH gene was knocked down in HCT-8 cells. CCK8 and cell wound scratch assays were further performed in UGDH wild-type and knocked-down HCT-8 cells.
Results: UGDH is remarkably decreased in CRC compared to normal tissues, which predicts a poor prognosis. UGDH’s lower expression is associated with a high gene promoter methylation level and genome deletion. UGDH expression is proportional to immune cell infiltration and immune-related genes. UGDH expression is correlated to the p53 signaling pathway. Compared to the normal colonic epithelial cells, UGDH is downregulated in CRC cells. Knockdown of UGDH in HCT-8 cells promotes the proliferation and migration ability.
Conclusions: UGDH could be useful as a valuable prognostic biomarker and potential therapeutic target in CRC. UGDH could inhibit the proliferation and migration of CRC cells, possibly by modulating the p53 signaling pathway.
Prehabilitation in Major Surgery: An Evaluation of Cost Savings in a Tertiary Hospital
Authors: Mudarra-García Natalia , Roque-Rojas Fernando , Izquierdo-Izquierdo Visitación , García-Sánchez Francisco Javier 
Published: February 2025

Abstract

Background: Prehabilitation emerges as a program designed to enhance the patient’s functional capacity before surgery by addressing three key aspects: physical activity, proper nutrition, and the reduction of anxiety and frustration. Various prehabilitation models exist to optimize patients before surgery, including programs led by anesthesiologists, surgeons, endocrinologists, etc. The existing models demonstrate that appropriate patient optimization before surgery reduces postoperative complications, hospital stay, and re-admissions.(2)
Methods: A total of 211 patients were included, of whom 76 were not enrolled in the surgical prehabilitation program based on the advanced practice nursing and internist model (control group), while 135 benefited from this program (intervention group).; (3)
Results: Following the surgical prehabilitation model led by an advanced practice nurse in collaboration with an internist, a significant reduction was achieved in blood transfusions (p=0.014), postoperative complications (p<0.001), and hospital length of stay (p=0.004). Likewise, annual costs were reduced by a total of €593,453. (4)
Conclusions: Following a surgical prehabilitation model reduces the number of postoperative complications, decreases hospital length of stay, and increases the savings on red blood cell transfusions. Likewise, implementing a model led by an advanced practice nurse in collaboration with an internist significantly reduces the annual costs of a tertiary hospital.
Experimental Study on Laser Structuring of Circumferential Surfaces on Cemented Carbide for Slip Force Enhancement
Authors: Schlegel Eduard , Hartmann Felix 
Published: February 2025

Abstract

Due to a combination of high surface quality, rigidity, and low tool change times, shrink fit tool holders are a popular choice for machining tool clamping. However, tool slippage and runout can be observed at high-performance machining, especially with low tool diameters. This study provides a possible solution to prevent slippage in shrink fit tool holders. For this, honeycomb-like laser structures are applied to circumferential surfaces of fine-grained 4-mm carbide tool rods with different material compositions. Laser structuring is carried out with a Yb:YAG infrared laser with a pulse duration of 900 fs. In preliminary tests, the ablation behavior of the laser is studied for different materials. Using this data, laser structures with different structure depths and spot-to-spot spacings are generated by varying the laser parameters. Laser-structured tool rods are then clamped in a specifically designed test bench using a radial clamping element and loaded until slippage occurs. Laser-structured tool rods achieve a slip load up to 2.4 times higher than their unstructured counterparts. Slippage almost exclusively occurs due to the wear of the radial clamping element used in the test bench. Lower spot-to-spot spacings as well as higher structure depths generally result in higher slip loads. However, at structure depths of 15 µm or greater, tool rods fracture, which is attributed to the notch effect. An effect of the composition of the tool rods on the slip loads or laser ablation behavior could not be observed.
Global Population Dynamics and Evolutionary Selection in Classical Swine Fever Virus Complete Genomes: Insights from Bayesian Coalescent Analysis
Authors: Mahadevaswamy Roopa , Muruganantham Vijay , Ramesh Varsha , Mambully Shijili , Suresh Kuralayanapalya Puttahonnappa , Hiremath Jagadish , Nayakvadi Shivasharanappa , Gulati Baldev , Patil Sharanagouda 
Published: February 2025

Abstract

Classical swine fever virus (CSFV) is a pathogen that affects pigs and wild boars. This contagious RNA virus is a high threat to swine industries throughout the world because it has high mortality and morbidity rates, leading to economic losses. Although previous studies primarily focused on isolated regions or specific genotypes, our study leverages a global dataset of 220 CSFV whole-genome sequences retrieved from the NCBI repository along with2 CSFV complete genome sequence from our laboratory (Accession number: MH734359.1 and OR4282229.1) and carefully curated to 66 sequences. The refined dataset is subjected to Bayesian analysis along with selection pressure analysis. The outcome of this experiment, the mean substitution rate was estimated at 2.06 x 10− 3 substitutions/site/year with the Highest Posterior Density (HPD) (95% HPD 6.8012 x 10− 4 − 3.3044 x 10− 3), and the estimated average time to the most recent common ancestor (tMRCA) for the analyzed dataset was the year 1877 (95% HPD 1833.8181–1932.3176). Among the curated data set, 2 CSFV complete genome sequences (Accession number: MH734359.1 and OR428229.1) from our laboratory showed of Chinese origin. Additionally, pervasive and episodic selection pressure revealed that both had ongoing diversifying natural positive selection, which could lead to increased genetic diversity and possibly emergence of the new lineage. This potential information could be used for future evaluation of strategies to control emerging new genotypes of CSFV with high mortality and morbidity.
Development and validation of the Brazilian Dietary Guidelines Adherence Score (BraScore): a novel index to assess the adherence to the Dietary Guidelines for the Brazilian Population
Authors: Souza Thays Nascimento , Gabe Kamila T. , Cacau Leandro T. , Carneiro Letícia B.V. , Lassale Camille , Levy Renata B. , Inês R.R. Castro , Louzada Maria Laura C. 
Published: February 2025

Abstract

Background: The Dietary Guidelines for the Brazilian Population (hereinafter referred to as the Guidelines) provide recommendations for a healthy and sustainable diet.
Objective:To describe the development and validation of the Brazilian Dietary Guidelines Adherence Score (BraScore).
Methods:This work involved multiple methodological steps: defining guiding principles for the development, identifying food components, setting cut-off points for scores, and assessing content validity, construct validity, and reliability. To evaluate construct validity, we used dietary intake data from the 2017-2018 Household Budget Survey. It included: the assessment of the correlation of the BraScore with total energy intake, the evaluation of the BraScore variability and the number of patterns explaining this variability through Principal Component Analysis, the ability to distinguish between population subgroups (gender, age group, income quartiles, and area of residence), and the analysis of the scores for diets developed by nutritionists. Reliability was assessed using Cronbach's Alpha.
Results:The BraScore is composed of 10 components divided into three dimensions: to be consumed (legumes; fruits; vegetables; diversity), to be limited (red meat; eggs, fish, milk, and poultry; processed foods; table sugar; table salt), and to be avoided (ultra-processed foods). The BraScore ranges from 0 to 100 points, with higher scores indicating greater adherence to the Guidelines. The analyses showed weak correlation with energy intake (coefficient: -0.13). There was substantial variability among individuals (scores ranged from 28.9 to 86.2 between the 1th and 99th percentiles), with multiple patterns explaining this variability. The score distinguishes population groups (elderly individuals, people with lower income and residents of rural areas tend to have a higher BraScore) and higher scores were found for diets developed by nutritionists (ranging from 84.6 to 97.6 points). Cronbach’s Alpha was 0.53, indicating acceptable reliability.
Conclusions:The BraScore achieved satisfactory performance in assessing adherence to the Dietary Guidelines for the Brazilian Population.
Amendment-assisted myco-phytostabilization potential of plants on copper tailings in a pot-scale experiment
Authors: Neagoe Aurora , Manu Minodora , Onete Marilena , Mihai Luiza-Silvia , Dincă George , Jianu Denisa , Stelian Ion , Iordache Virgil 
Published: February 2025

Abstract

Mining activities have as a secondary result the production of residues stored in tailings dumps and ponds which lead to the serious environmental hazards over time. For this reason, it is necessary to install and accelerate the ecological succession on the tailings ponds, their phytostabilization being an ongoing challenge. The aim of this study was to apply an eco-technology already successfully demonstrated on two tailing dams, on a third one with a specific geochemical structure, knowing that each polluted area is a unique entity. A pot-scale experiment was carried out in a growth chamber amending the mining substrate with top soil and green fertilizers, inoculating it with 1% and 2% fungi, and sowing it with Agrostis capillaris alone, or mixed with Melilotus albus. The experimental design consisted of 14 treatments, each with 5 replicates. For the treatment with 2% fungi and sown with a mixture of two plant species, plant biomasses, technosoil respiration, total Kjeldahl nitrogen content and assimilatory pigments recorded statistically significantly higher values, compared to the other treatments. Lipid peroxidation and the content of some toxic elements in plants registered a statistically significant decrease for the same treatment. There was no statistically significant difference in mycorrhizal colonization between 1% and 2% fungi under these particular experimental conditions. This eco-technology could be successfully applied to the surface of the new tailing dam. The novelties are the success of inoculation with both 2% and 1% fungi, which substantially reduces the costs of large-scale phytostabilization using a mixture of two plants.
Natrojarosite formed in the Matanomadh Formation, Kutch, India; a Na analog of jarosite on Mars
Authors: Ray Dwijesh , Das Aditya , Sarkar Subham , Bhattacharya Satadru , Nayak Chandrani 
Published: February 2025

Abstract
We report mineralogy, chemical composition, visible near-infrared (VNIR) spectroscopy, and X-ray near-edge spectroscopy of phyllosilicate-sulfate mineral assemblages including natrojarosite from Matanomadh Formation (Palaeocene) of the Kutch region in Gujarat, India. The unit cell parameters of sulfate minerals and VNIR spectral properties are consistent with natrojarosite and other minerals. The mineralogy and unit cell parameters indicate supergene or hydrothermal alteration condition within the Kutch region. The Fe oxidation record (Fe3+/ total Fe ∼ 0.83) is quantified using Fe K-edge XANES. Additionally, the Fe-S bond length for natrojarosite is determined to be 3.158 Å, and the experimental data fits well with the modeled iron sulfate data curve. The occurrences of natrojarosite and associated natroalunite and kaolinite in the post-Deccan volcanic province are consistent with an oxidizing environment and periodic shift of humid to arid environments that appear to be similar to the early geologic history of Mars. The oxidative alteration of pyrite further enhances the formation of natrojarosite. Our results, in concert with earlier studies, highlight the formation process of natrojarosite and provide insights into detailed mineralogy at the Kutch region and the magnitude of the redox state. The natrojarosite and the associated minerals (including anhydrite and other sulfates) argue for acidic and water-limited conditions analogous to the Noachian-Hesperian epoch of Mars with implications for past weathering processes.
How to Wash a Body
Authors: Bu Shea Staci 
Published: February 2025

It is common to learn about natural body care and bathing rituals through end-of-life doula training. At the time of my training in 2020/2021, I hadn’t washed a dead body yet, so I practiced what I was learning on my partner and later described the event in “How to Wash a Body.” The literary examples I’ve come across so far that recount this act of care often describe the uncanny aspects of encountering the loved one’s body becoming corpse. I wanted to emphasize the reverse: the current aliveness of my partner, awareness and forms of preparedness for my/another’s death, and how learning and performing such acts of care like washing a beloved’s body is an integral part of grieving and reconnection in the chain of events following their death.