bluuebunny/crossref_metadata_2025_split huggingface dataset:
The immediate effects of Porang-processed rice (Amorphophallus muelleri) on triglyceride levels in patients with type 2 diabetes mellitus and dyslipidemia
Authors: Wicaksono Satrio Adi , Palisma Zahrien Assyifa Nur , Nugroho Taufik Eko , Utami Sulistiyati Bayu 
Published: May 2024

Link of Video Abstract: https://youtu.be/HSObtemRZ0M

Background: Diabetes Mellitus (DM) is a major cause of death and disability worldwide. Diabetes mellitus is related to metabolic disorders in glucose and lipid levels. Porang tubers contain glucomannan, a substance with many health benefits, such as ameliorating blood glucose and lipid profiles, and has been processed as many food products, such as porang-processed rice (PR). This study investigated the immediate effects of PR on triglyceride levels compared to white rice (WR) in patients with diabetes mellitus (DM) and dyslipidemia.
Methods: It was a randomized clinical study with an experimental pre-and post-test control group design held from October to November 2021 in Diponegoro National Hospital, Semarang, Indonesia. A total of 24 study subjects were selected by consecutive sampling. The inclusion criteria were (1) patients diagnosed with diabetes mellitus (DM) or who have been consuming routine oral antidiabetic drugs and (2) have signed the written informed consent. These subjects were divided into 2 groups, i.e., the treatment group (n=12) and the control group (n=12). The treatment group was given a porang rice (PR) diet of 300 grams, 3 times a day, for 5 days. The control group will consume a white rice (WR) diet for 5 days. Triglyceride levels were measured and compared between both groups before and after the treatment. Triglyceride levels were measured using venous blood sampling. All subjects were still consuming routine medications during the study.
Results: There were no differences in participants' baseline demographic and clinical characteristics. At pre-treatment, there was no significant difference in triglyceride levels between the group with PR and WR (201.5 ± 102.29 vs 220.8 ± 92.08; respectively, p=0.564). At post-treatment, there was no significant difference in triglyceride levels between the group with PR and that with WR (200.0 ± 90.67 vs 224.3 ± 88.03; respectively, p=0.513). However, there was a larger decrease of triglyceride levels (Δtriglyceride) in a group with PR compared to that with WR (29.4 ± 22.81 vs 12.6 ± 7.12; p=0.016).
Conclusion: There were no significant differences in the triglyceride levels before and after porang-processed rice (PR) or white rice (WR) in patients with DM and dyslipidemia. However, there was a larger decrease in triglyceride levels (Δtriglyceride) in a group with PR compared to that with WR. If confirmed by further studies, porang-processed rice might have the role of nutraceutical plants in stabilizing lipid profiles, especially triglyceride levels, in patients with DM and dyslipidemia.
The relationship between the cycle threshold value of SARS CoV-2 with neutrophil lymphocyte ratio (NLR), absolute lymphocyte count (ALC), severity degrees, long of treatment, and outcomes COVID-19 patients
Authors: Aina Nurlaila  , Mohamad Isa  , Rahmiati Lao  , Ira Nurrasyidah  , Isa Ansori  , Erna Kusumawardhani  
Published: May 2024

Link of Video Abstract: https://youtu.be/uGfZNQrEQqY

Background: Coronavirus disease 2019 (COVID-19) has caused serious public health problems since the end of 2019. Viral load is known in COVID-19 infection, which indicates the number of causative agents and is indirectly assessed by the Cycle threshold value (Ct value). Ct value assessment has not been declared an essential parameter in COVID-19 infection. Due to the high number of COVID-19 cases, an additional strategy is needed to help identify patients at high risk of experiencing severe clinical conditions by knowing the relationship between the Ct value of SARS CoV-2 and neutrophil lymphocyte ratio (NLR), absolute lymphocyte count (ALC), severity, length of stay, and outcomes.
Methods: This was an analytic observational study with cross-sectional approach in confirmed COVID-19 patients to investigate the relationship between the Ct value of SARS CoV-2 and NLR, ALC, severity, length of stay, and outcome of COVID-19 patients. There were 337 patients analyzed with chi square test.
Results: The results of this study indicate that the majority of subjects were male (51%), aged <60 years (27%), Ct value ≤29 (70%), had a critical severity (36.5%), length of stay >10 days (64.1%) and survived (74.7%). Inflammatory markers examination shows NLR<3,13 (57.9%) and ALC<1500 (66.2%). The chi-square test shows a significant relationship between Ct value and ALC, degree of severity, and outcome in COVID-19 patients (p <0.05). No association was found between Ct value, NLR, and length of stay (p>0.05).
Conclusion: There is a relationship between Ct value and ALC, degree of severity, and outcome in COVID-19 patients.
Wound healing of gaster perforation with Human Dried Amniotic Membrane (H-DAM) as biomaterial patch viewing from the fibroblasts counts and collagen density
Authors: Ramadhani Astri Taufi , Ariandi Setiawan  , I Gusti Bagus Adria Hariastawa  
Published: May 2024

Link of Video Abstract: https://youtu.be/UldBMnzIelE

Background: Gastric perforation in neonates is an emergency in neonatology with a mortality rate of up to 75%. Many studies have been carried out to improve tissue healing, including using various surgical techniques and materials, one of which is using H-DAM technology. Therefore, this study aims to evaluate the differences in the number of fibroblasts and collagen density in gastric perforation repair with H-DAM as a biomaterial patch compared to using an omental patch in New Zealand white rabbits.
Methods: A true-experimental study was conducted among 30 samples of rabbits and none of them dropped out. The inclusion criteria for this study are New Zealand White Rabbit male sex, age 6-9 months with a weight of 2-3 kg, healthy and active. The Exclusion criteria for this study are rabbits not fasted for 12 hours. During the 12-hour fasting period, it behaved aggressively, attacked other rabbits, and found surgical site infection. Data were analyzed using SPSS version 25.0 for Windows.
Results: From the examination results, there was a significant difference in gastric healing in terms of examining the number of fibroblasts with the Kruskal-Wallis test (p=0.000. The One-way ANOVA analysis found that the three data groups had no significant difference (p=0.234).
Conclusion: There is an increase in the number of fibroblasts and collagen density in gastric perforation repair with H-DAM as a biological dressing compared to primary repair of gastric perforation using an omental patch in rabbit models so that H-DAM can be the repair technique of choice in gastric perforation in the rabbit.
Survival rate of children acute lymphoblastic leukemia at the end of therapy protocol with minimal residual disease (MRD) in Prof I G.N.G. Ngoerah General Hospital Denpasar
Authors: Sanjaya Dewa Gde Windu , Ketut Ariawati  , Putu Junara Putra  , Karyana I Putu Gede , Eka Gunawijaya  , I Made Gde Dwi Lingga Utama  
Published: May 2024

Link of Video Abstract: https://youtu.be/5DFCQHg86rU

Background: Acute lymphoblastic leukemia (ALL) is the most common malignancy in children. Although the survival rate of pediatric patients with ALL is currently improving, cases of relapse still occur. Minimal residual disease (MRD) status is a prognostic factor that plays an important role in recurrence of ALL patients who have been through induction therapy. Aim: To determine the survival rate in pediatric patients with ALL based on negative MRD examination is better than positive MRD at the end of therapy.
Method: A retrospective cohort study with inclusion criteria including pediatric patients aged 1 to 18 years who were diagnosed with ALL in the period of 2017-2019 at Sanglah General Hospital, Denpasar. Subject’s recruitment was initiated when the minimum number of subjects was fulfilled.
Result: From 32 research subjects, the mean age was 5.1 years, the majority obtained MRD+ results, the dominant sex was male, the average leukocyte was 28.33 thousand, most of the subjects had no mediastinal masses, and generally experienced remissions. MRD levels were found to be significantly lower in remitting patients than patients who did not achieve remission (p value <0.05). The Kaplan-Meier estimates for event-free survival on MRD status (negative versus positive) were 84.6% and 42.1% (P = 0.030).
Conclusion: There was a significant relation between MRD levels and the survival rate to achieve remission and MRD levels are significantly lower in remitting patients than patients who do not achieve remission.
Relationship of quinolinic acid and serotonin with depression and pain degree in cancer pain patients: a cross-sectional study
Authors: Ningrum Aji Mustika , Airlangga Prananda Surya , Maskoep Wiwiek Indriyani , Putri Herdiani Sulistyo 
Published: May 2024

Link of Video Abstract: https://youtu.be/zg5vubHMcDY

Introduction: Chronic pain requires a thorough assessment if it persists in patients with cancer. Depressive disorder is one of the psychosocial problems that can occur in cancer patients. Depressive disorders affect up to 34.4% of patients with cancer in Indonesia, causing increased morbidity and complicating the management of patients. Quinolinic acid (QUIN) and serotonin (5-HT) are chemicals that can affect pain perception and depressive disorders. This study aims to analyze the relationship between quinolinic acid and serotonin levels with depression and pain degree in cancer pain patients.
Methods: A cross-sectional study design was conducted at the Palliative Polyclinic of Dr. Soetomo Surabaya General Hospital, Indonesia. Patients were collected with purposive sampling. The patient's quinolinic acid and serotonin plasma were collected through blood samples and assessed using enzyme-linked immunosorbent assay (ELISA) method. Spearman's comparison test determined the correlation between quinolinic acid and serotonin levels with depression and pain degree.
Results: A total of 76 cancer patients were included in this study. The cancer types reported were pelvic cancer (23 patients, 30.3%), head and neck cancer (21 patients, 27.6%), abdominal cancer (ten patients 13.2%), breast cancer (seven patients, 9.2%), lung cancer (five patients, 6.6%), skin cancer (three patients, 3.9%), and other types of cancers (seven patients, 9.2%). As many as 24 patients (31.6%) had mild depression and only three patients (3.9%) experienced major depression. Mild pain was reported by 47 patients (61.8%) and 11 patients (14.5%) suffered from severe pain. Spearman's comparison test was conducted on quinolinic acid and serotonin levels against depression degree and pain degree, resulting in a weak correlation.
Conclusion: Quinolinic acid and serotonin levels are related to depression and pain degree in cancer pain patients (p<0.05), though with a weak correlation. However, further study is needed to confirm the findings of this study.
Effect of Blood Flow Restriction in Low-Intensity Resistance Training of the Quadriceps Femoris Muscle on Joint Position Sense and Threshold to Detect Passive Motion in Patients with Knee Osteoarthritis
Authors: Sri Wulandari Pramana I Gusti Agung Ayu , Subadi Imam , Wardhani Indrayuni Lukitra , Andriana Meisy , Utomo Dwikora Novembri , Melaniani Soenarnatalina 
Published: May 2024

Backgrounds: The functional ability of knee OA (KOA) patients is mainly affected by muscle weakness and poor proprioception function. Quadriceps femoris strengthening exercises can improve proprioceptive function in patients with KOA, whereas low-intensity resistance exercises with Blood Flow Restriction have been shown to produce hypertrophy and increase muscle strength equivalent to high-intensity resistance exercises. However, prescriptions for exercise with BFR are still very diverse, and only a few studies show the effects of BFR training on proprioceptive function in patients with KOA. This study aims to determine the impact of BFR in LI-RT of the quadriceps femoris muscle on joint position sense and threshold to detect passive motion in patients with KOA.
Methods: This randomized control trial study designed a clinical experiment with a before and after test. The research enrolled 28 people with KOA grades 2 and 3. The JPS and TTDPM, which reflect proprioceptive function, were measured before and after 6 weeks of exercise. This study's statistical analysis utilized the Monte Carlo test, independent t-test, and paired t-test. The effect size was noticed using Cohen's-d calculation to investigate the statistical influence of alterations further. The significance level was less than 0.05.
Results: The mean age of the control group was 61.43 ± 5.70 years old, and the treatment group was 57.71 ± 5.25 years old. There were significant improvements in JPS and TTDPM results before and after training in each group (p < 0,05). There was no significant difference in JPS and TTDPM results between the two groups on the post-test on delta values (p> 0,05).
Conclusions: The addition of BFR in LI-RT for 6 weeks did not affect JPS and TTDPM in patients with KOA.
Clinical research capacity evaluation at Prof. I.G.N.G Ngoerah General Hospital, Denpasar: Teaching general hospital, Indonesia
Authors: Agustini Tri Fajari , Sjaaf Amal Chalik , Sulistiadi Wachyu , Hendrawan Harimat 
Published: May 2024

Link of Video Abstract: https://youtu.be/0zW7g_T0heE

Introduction: Applying research activity in hospitals in Indonesia is a kind of challenge. This study aimed to assess the research’s capacity in Prof. I.G.N.G Ngoerah General Hospital. It is related to the indicators and cultural analysis at the team, organization, and individual levels in Prof. I.G.N.G Ngoerah General Hospital.
Methods: A cross-sectional study and qualitative analysis using Focus Group Discussion (FGD) were conducted in July-August 2022 at Prof. I.G.N.G Ngoerah General Hospital. The Research Capacity and Culture (RCC) validated survey measured self-reported research capacity at leadership, individual, team, and organization levels. Additionally, this study explored barriers and motivators. The rate of research capacity decisions and the domains in this study use the ROC curve. This statistical analysis used chi-square with a significance of p-value < 0.05.
Results: One hundred and thirty respondents were analyzed. The individual characteristics were 45-54 years old, male, medical specialist, clinician without structural position, with a master’s degree or specialist, internal medicine department and pediatric department, 0–10 years of work history, 1–10 journal publications, and having a research history. In leadership and team capacity, most have low scores, and in individual capacity, organization and research capacity have high scores. There is a statistically strong relationship between each domain and research capacity.
Conclusions: High research capacity in a hospital is very important. Evidence-based research can be used to support the services and progress of the hospital itself, especially as a teaching hospital.
Exploring rutinoside's impact on inflammation in a rat knee OA model induced by monosodium iodoacetate (MIA)
Authors: Normasari Rena , Purwanto Bambang , Tinduh Damayanti 
Published: May 2024

Link of Video Abstract: https://youtu.be/Dl8sYvPfd6o

Introduction: Osteoarthritis (OA) is a common joint disease characterized by persistent inflammation and cartilage breakdown. Monosodium iodoacetate (MIA) is often used to generate OA in rats. This study aims to explore the anti-inflammatory benefits of rutinoside, a natural flavonoid glycoside, in rats with MIA-induced knee OA.
Methods: The male Wistar rats were divided into five groups (n = 6) and randomly allocated to one of five treatments: control, OA, rutinoside, glucosamine sulfate, and sodium diclofenac-treated group. 3 mg of monosodium iodoacetate (MIA) was injected intra-articularly into the knee joints of rats to induce osteoarthritis. Rutinoside, glucosamine sulfate, and sodium diclofenac were given daily for four weeks. Body weight, joint swelling, knee bend score, interleukin-1 (IL-1) levels, interleukin-8 (IL-8) levels, and C-terminal telopeptide type II collagen (CTX-II) levels were all assessed.
Result: Rutinoside significantly decreased body weight loss, joint edema, and knee bend test scores compared to the untreated OA group. Furthermore, rutinoside was equally effective as glucosamine sulfate and sodium diclofenac in these parameters. The rutinoside, glucosamine sulfate, and sodium diclofenac groups had significantly lower IL-1, IL-8, and CTX-II levels than the untreated OA group.
Conclusion: Rutinoside reduced inflammatory responses, lowered joint edema, and improved knee bend test scores in a rat model of MIA-induced osteoarthritis. Its efficacy in preventing illness was comparable to glucosamine sulfate and sodium diclofenac. More study is needed to better understand rutinoside's underlying mechanisms and long-term consequences for treating osteoarthritis.
The effect of ascorbic acid on leukocyte reduction in burns injury patient: A short communication
Authors: Wahdono Muhammad Ihsan , Saputro Iswinarno Doso , Budi Agus Santoso 
Published: May 2024

Link of Video Abstract: https://youtu.be/-_-efYtOGxk

Introduction: Challenges in managing burn injury include a high risk of sepsis and mortality. The study aimed to determine the effect of ascorbic acid on leukocyte reduction in burns injury patients.
Methods: The design of this study was a case series reported using retrospectives. Data collection was carried out from January to December 2020. All participants were diagnosed with burn injuries. Participants received burn wound care with and without ascorbic acid or Vitamin C (Vit. C). Participants measured leukocyte levels on the first and fifth days.
Result: The mean age of the participants was 32.08 ± 17.78 years, of which most of the participants were men (59.38%) with an average age of 35.21 ± 13.45 years, while the average age in women was 27.51 ± 22.52 years old. The mean TBSA of participants was 34.20 ± 21.21%, of which the mean TBSA for males was 39.45 ± 20.01% and for females 26.54 ± 21.32%. The mean participant leukocyte value on the first day was 21.49 ± 9.55 × 103/µL and on the fifth day, it was 11.26 ± 3.86 × 103/µL (z = -4.507; p <0.001). There was a significant difference in the leukocyte participant values on days 1 and 5 of -10.23 ± 9.77 × 103/µL (t = -2.504; p = 0.018).
Conclusion: Use of Vit. C in the management of burn injury has been shown to significantly reduce the number of leukocytes on the fifth day and reduce the risk of sepsis and mortality.
Risk factors for increasing leprosy treatment dropout cases reported in specific areas in Tangerang District
Authors: Sity Kunarisasi  , Jatty Puspaningtias  , Farah Segeir  
Published: May 2024

Link of Video Abstract: https://youtu.be/WPu8KQqNFNM

Introduction: In 2020, Indonesia announced the elimination of leprosy in the whole country, including the Banten Province, with new cases detected 568 cases (4.8 per 100,000 population), higher than the national average of 4.12 per 100,000 population. Although information on the percentage of dropouts in Indonesia is not known, it still occurs in the field, If the case is cleared out unchecked, it will become a source of transmission of wellbeing problems in the community. This study aims to determine the influence of socio-demographic factors, leprosy patients, and health services on leprosy dropout rates and detect new cases in the Panongan Community Health Center working area.
Methods: Secondary data on leprosy patients at the Panongan Community Health Center during 2019-2022 and primary data from cross-sectional surveys through home visits, interviews, face-to-face, and screening. Screening for leprosy symptoms in close contact with the patient's family using a questionnaire that includes independent variables of socio-demographic, patient, and health center with the dependent variable of treatment dropout. Purposive sampling technique in 5 villages with leprosy cases. The total sample size was 79 people. Data were processed and analyzed using STATA 14.0.
Results: The logistic regression test was found to be significant (p-value < 0.05) including age, (p=0.003), occupation (p=0.002), stigma (p=0.001), family of leprosy patients (p=0.003), close contact (p=0,000), healthy eating habits (p=0.002), perception of taking medicine (p=0.000) and a woman, 60 years old, was found to be infected with leprosy within the family of a drug withdrawal patient who was in near contact for 1 year, although multivariate testing was not statistically significant (p-value: > 0.05).
Conclusion: Increasing compliance through health education and motivation of patients and families, also monitoring medication taking by health service staff, groups of former patients, and cadres.
Pregnancy with uterine didelphys and history of recurrent pregnancy loss: Case report
Authors: Pratama Dito Oktawijaya , Wicaksono Budi 
Published: May 2024

Link of Video Abstract: https://youtu.be/H7Y7XoPOUAw

Background: Uterine didelphys is an embryologic disorder that arises from the failure of Mullerian duct fusion. It is characterized by the presence of two distinct cervices, two vaginas, and two uterine horns. Obstetric complications may arise during pregnancy when uterine didelphys is present; these may include spontaneous abortion, premature labour, and fetal malpresentation.
Case Presentation: A 25-year-old woman has been married for three years and had history of six gravid, zero parity, and five abortion. The patient had uterine didelphys. A fully septated uterus with double cervices and vaginas was found on pelvic magnetic resonance imaging. The patient arrived at the hospital at 27/28 weeks. Periodic sonograms demonstrated breech presentation and no (Intrauterine Growth Restriction) IUGR evidence. At 38/39 weeks, the patient was scheduled for cesarean surgery. Uterine didelphys morphology, pregnancy on the left side of the uterus, and the septum separating the left and right uterine cavities were all observed during the caesarean section. The newborn had three umbilical cords wrapped around his neck. The infant was female, 2800 grams, 48 cm, Apgar score 7-8, Ballard score (BS) 38 weeks, Lubchenco score (LS) p25-50.
Conclusion: Antenatal care is required for investigating risks of uterine didelphys, including cervical incompetence, spontaneous abortion, and preterm birth, using serial sonograms to assess fetal well-being and cervical length.