bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hierarchical Bayesian adaptive lasso methods on exponential random graph models
Authors: Han Dan , Modisette Vicki , Forthofer Melinda , Paul Rajib 
Published: April 2024

AbstractThe analysis of network data has become an increasingly prominent and demanding field across multiple research fields including data science, health, and social sciences, requiring the development of robust models and efficient computational methods. One well-established and widely employed modeling approach for network data is the Exponential Random Graph Model (ERGM). Despite its popularity, there is a recognized necessity for further advancements to enhance its flexibility and variable selection capabilities. To address this need, we propose a novel hierarchical Bayesian adaptive lasso model (BALERGM), which builds upon the foundations of the ERGM. The BALERGM leverages the strengths of the ERGM and incorporates the flexible adaptive lasso technique, thereby facilitating effective variable selection and tackling the inherent challenges posed by high-dimensional network data. The model improvements have been assessed through the analysis of simulated data, as well as two authentic datasets. These datasets encompassed friendship networks and a respondent-driven sampling dataset on active and healthy lifestyle awareness programs.
Unlocking the Potential: A Systematic Review of Master Protocol in Pediatrics
Authors: Li Yimei , Nelson Robert , Izem Rima , Broglio Kristine , Mundayat Rajiv , Gamalo Margaret , Wen Yansong , Pan Haitao , Sun Hengrui , Ye Jingjing 
Published: April 2024

AbstractThe use of master protocols allows for innovative approaches to clinical trial designs, potentially enabling new approaches to operations and analytics and creating value for patients and drug developers. Pediatric research has been conducted for many decades, but the use of novel designs such as master protocols in pediatric research is not well understood. This study aims to provide a systematic review on the utilization of master protocols in pediatric drug development. A search was performed in September 2022 using two data sources (PubMed and ClinicalTrials.gov) and included studies conducted in the past10 years. General study information was extracted such as study type, study status, therapeutic area, and clinical trial phase. Study characteristics that are specific to pediatric studies (such as age of the participants and pediatric drug dosing) and important study design elements (such as number of test drug arms and whether randomization and/or concurrent control was used) were also collected. Our results suggest that master protocol studies are being used in pediatrics, with platform and basket trials more common than umbrella trials. Most of this experience is in oncology and early phase studies. There is a rise in the use starting in 2020, largely in oncology and COVID-19 trials. However, adoption of master protocols in pediatric clinical research is still on a small scale and could be substantially expanded. Work is required to further understand the barriers in implementing pediatric master protocols, from setting up infrastructure to interpreting study findings.
A retrospective chart review assessing antibiotic treatment of hospitalized patients with discordant Clostridioides difficile assays in an urban hospitalized setting
Authors: Stoddart Clare , Kuo Irene , Spence Matthew A. , Palmore Tara N. 
Published: April 2024

Abstract
Clostridioides difficile infection (CDI) threatens vulnerable populations in health care. Two-step testing improves specificity, avoiding over-treatment. This study analyzed inpatient records to estimate diagnostic outcomes and identify characteristics associated with treatment after discordant testing. Among discordant patients, those aged 65+ years were significantly more likely to be prescribed antibiotics (67% vs 39%).
Subordination and the Wrong of Discrimination
Authors: Viehoff Daniel 
Published: April 2024

AbstractSophia Moreau, in her important book, offers an insightful account of (one strand of) the wrong of discrimination based on the evil of subordination. My symposium contribution seeks to clarify the structure of Moreau's account of subordination and its normative and axiological status. On one plausible view, subordination is fundamentally bad or wrong. On another view, subordination is a distinctive social phenomenon, which is bad or wrong only derivatively. I will outline each view, and consider the implications each has for certain issues central to Moreau's book.
Multiple Consciousness and Philosophical Method
Authors: Eisen Jessica 
Published: April 2024

AbstractSophia Moreau's Faces of Inequality adopts a provocative philosophical methodology: centring the experiences of victims of discrimination, and the basic contours of anti-discrimination law, in developing an account of wrongful discrimination. If, however, we take seriously sceptical accounts of law developed within feminist and critical race scholarship, we begin to see a tension within Moreau's methodological dyad: if victims of discrimination often experience discrimination law as hostile and disbelieving, how can both be treated as authoritative? This contribution will explore this tension as it emerges in Faces of Inequality, in light of Mari Matsuda's theory of “multiple consciousness.”
On the Periodic Variation of the Ion Density in the Martian Dayside Ionosphere During the Regional Dust Storm in September 2016
Authors: Hara Takuya , Masunaga Kei , Terada Naoki , Sakai Shotaro , Osanai Taiga , Seki Kanako , Fowler Christopher M. , Hanley Kathleen Gwen , McFadden James P. , Curry Shannon M. 
Published: April 2024

AbstractDust storms and the atmospheric waves can play a significant role in the dynamics in the upper neutral atmosphere of Mars. Recent observations found that a periodic variation of neutral H and O exists in the upper atmosphere, which is likely associated with atmospheric waves that occurred during the regional dust storm on 4 September 2016. However, such periodic variations accompanying the dust storm are far from understood in terms of the Martian ionized particles (i.e., ionosphere). Here we investigated the periodic variation of the ion density in the Martian ionosphere during the regional dust storm in September 2016 based on the MAVEN/STATIC observations. Assuming a simple Chapman layer model, we implemented numerical fitting for the ion density altitude profile to retrieve the peak ion densities in the Martian ionosphere. We then applied periodogram analysis to these peak ion densities in order to identify the peak periodicities together with their confidence levels. We identified several distinct peak periodicities with a scale from ∼1 day up to ∼20 days. The peak periodicities around 6–9 days are comparable to those seen in the Martian neutral atmosphere. In addition, the other peak periodicities likely correspond to the periodic crossings of the local crustal fields and periodic variation of the upstream solar wind, indicating a strong regional coupling between the lower atmosphere and the upstream solar wind.
The Role of Cloud Radiative Effects in the Propagating Southern Annular Mode
Authors: Lu Jian , Harrop Bryce E. , Lubis Sandro W. , Smith Samuel , Chen Gang , Leung L. Ruby 
Published: April 2024

AbstractThe Southern Annular Mode (SAM) is the most dominant natural mode of variability in the mid‐latitudes of the Southern Hemisphere (SH). However, both the sign and magnitude of the feedbacks from the diabatic processes, especially those associated with clouds, onto the SAM remain elusive. By applying the cloud locking technique to the Energy Exascale Earth System Model (E3SM) atmosphere model, this study isolates the positive feedback from the cloud radiative effect (CRE) to the SAM. Feedback analysis based on a wave activity‐zonal momentum interaction framework corroborates this weak but positive feedback. While the magnitude of the CRE feedback appears to be secondary compared to the feedbacks from the dry and other diabatic processes, the indirect CRE effects through the interaction with other dynamical and thermodynamical processes appear to play as important a role as the direct CRE in the life cycle of the SAM. The cross‐EOF analysis further reveals the obstructive effect of the interactive CRE on the propagation mode of the SH zonal wind directly through the CRE wave source and/or indirectly through modulating other diabatic processes. As a result, the propagation mode becomes more persistent and the SAM it represents becomes more predictable when the interactive CRE is disabled by cloud locking. Future efforts on inter‐model comparisons of CRE‐denial experiments are important to build consensus on the dynamical feedback of CRE.
Circumtropical distribution and cryptic species of the meiofaunal enteropneust Meioglossus (Harrimaniidae, Hemichordata)
Authors: Defourneaux Éloïse , Herranz Maria , Armenteros Maickel , Sørensen Martin V. , Norenburg Jon L. , Park Taeseo , Worsaae Katrine 
Published: April 2024

AbstractHemichordata has always played a central role in evolutionary studies of Chordata due to their close phylogenetic affinity and shared morphological characteristics. Hemichordates had no meiofaunal representatives until the surprising discovery of a microscopic, paedomorphic enteropneust Meioglossus psammophilus (Harrimaniidae, Hemichordata) from the Caribbean in 2012. No additional species have been described since, questioning the broader distribution and significance of this genus. However, being less than a millimeter long and superficially resembling an early juvenile acorn worm, Meioglossus may easily be overlooked in both macrofauna and meiofauna surveys. We here present the discovery of 11 additional populations of Meioglossus from shallow subtropical and tropical coralline sands of the Caribbean Sea, Red Sea, Indian Ocean, and East China Sea. These geographically separated populations show identical morphology but differ genetically. Our phylogenetic reconstructions include four gene markers and support the monophyly of Meioglossus. Species delineation analyses revealed eight new cryptic species, which we herein describe using DNA taxonomy. This study reveals a broad circumtropical distribution, supporting the validity and ecological importance of this enigmatic meiobenthic genus. The high cryptic diversity and apparent morphological stasis of Meioglossus may exemplify a potentially common evolutionary ‘dead-end’ scenario, where groups with highly miniaturized and simplified body plan lose their ability to diversify morphologically.
Multiple objective energy optimization of a trade center building based on genetic algorithm using ecological materials
Authors: Kabiri Elham , Maftouni Negin 
Published: April 2024

AbstractIt is crucial to optimize energy consumption in buildings while considering thermal comfort. The first step here involved an EnergyPlus simulation on a trade center building located in Tehran, Bandar Abbas, and Tabriz, Iran. A multi-objective optimization was then performed based on non-dominated sorting genetic algorithm II (NSGA-II) in jEPlus + EA to establish the building in the selected city where would benefit the most from implementing the radiant ceiling cooling system. Efforts were undertaken to choose environmentally-friendly materials. The final solution by Pareto charts resulted in a 52% reduction in energy consumption, a 37.3% decrease in cooling load, and a 17.4% improvement in comfort hours compared to the original design. Annual emission of greenhouse gas reduced as 167.67 tone of CO2 equivalent emission, 25.77 ton of CH4, and 0.2 ton of NO2. The mentioned algorithm was conducted for the first time on a trade center, including a DOAS system and radiant ceiling cooling system. Simultaneously, the environmental-friendly materials were dealt with. The procedure holds significant relevance for the design and optimization of buildings in Iran, especially wherever the climate is hot and humid. This approach offers advantages to the environment by reducing the impact on energy resources and utilizing environmentally-friendly materials.
Biological feasibility of discharge a local WTTP sludge to sewer network and centralized WWTP; a case study: Tehran, Iran
Authors: Karami Samira , Farzadkia Mahdi , Kermani Majid , Kalantary Roshanak Rezaei , Pasalari Hasan 
Published: April 2024

AbstractOver the recent years, ever-increasing population growth and higher wastewater production has been a challenge for decentralized wastewater treatment plants (WWTPs). In addition, sludge treatment due to high cost for equipment and place make authorities to find a sustainable approach in both of economical and technical perspectives. One of the proposed solutions is transferring the sludge produced from decentralized WWTP to centralized WWTP. However, the appropriate proportional ratio of raw sludge to raw sewage is a challenge, otherwise, it make anaerobic conditions and sewage rotting along the sewer network based on permissible limit of dihydrogen sulfide (H2S) gas (5 ppm). In the present study, seven reactors with different ratios of sludge to raw sewage (0, 15, 20, 25, 50, 75, 100) were used to stimulate the feasibility of transferring Shahrake Gharb WWTP sludge along the wastewater transfer pipe to the centralized sewage treatment south Tehran WWTP plant in Tehran, Iran. The septic situation and H2S emission of different reactors within 7 h (Time to reach the compound in the south treatment plant) was analyzed by gas meter. The results indicated that the optimum ratio of sludge to raw sewage was 15% without H2S production during 7 h. In addition, due to the high volume of sludge produced by the Shahrake Gharb WWTP, the optimal ratio of lime to total solids (TS) in sludge (gr/gr) (0.6) increased the sludge loading rate from 15 to 30% without any H2S emission during the stimulation study period. Therefore, the lime stabilization and transfer of sludge from a decentralized WWTP to a centralized WWTP is a feasible way to manage the sludge and enhance the treatment capacity in local WWTP.
Neutron instrument concepts for a high intensity moderator at the European spallation source
Authors: Samothrakitis Stavros , Bertelsen Mads , Willendrup Peter K. , Knudsen Erik B. , Larsen Camilla B. , Rizzi Nicola , Zanini Luca , Santoro Valentina , Strobl Markus 
Published: April 2024

AbstractIn the course of the Horizon 2020 project HighNESS, a second moderator concept has been developed for the European Spallation Source, which complements the currently built moderator and is optimized for high intensity with a large viewable surface area. In this work we introduce conceptual designs for neutron instruments for condensed matter research designed to make optimal use of the capabilities of this moderator. The focus is on two concepts for small-angle neutron scattering and one neutron imaging instrument, which are intended to complement corresponding instruments that are already under construction at the European Spallation Source. One small-angle neutron scattering instrument concept resembles a conventional pinhole collimator geometry and aims to profit from the proposed second moderator by enabling to illuminate larger samples and providing particularly high resolution, drawing on a 30 m collimation and corresponding detector distance. A second small-angle neutron scattering instrument concept adopts nested mirror optics that enable to efficiently exploit the large moderator size and provide high resolution by focusing on the detector. The neutron imaging instrument concept is a typical pinhole instrument that can be found at continuous sources and draws on the corresponding strengths of high flux and large homogeneous fields-of-view, while still providing moderate wavelength resolution for advanced imaging methods.
Practice variation in surgical treatment for lumbar degenerative disc disease: exploring regional and hospital factors influencing surgical rates
Authors: van Munster Juliëtte J. C. M. , Halperin Ilan J. Y. , Ardesch Frank H. , van den Hout Wilbert B. , van Benthem Peter Paul G. , Moojen Wouter , Peul Wilco C. 
Published: April 2024

AbstractThe presence of significant, unwarranted variation in treatment suggests that clinical decision making also depends on where patients live instead of what they need and prefer. Historically, high practice variation in surgical treatment for lumbar degenerative disc disease (LDDD) has been documented. This study aimed to investigate current regional variation in surgical treatment for sciatica resulting from LDDD. We conducted a retrospective, cross-sectional analysis of all Dutch adults (>18 years) between 2016 and 2019. Demographic data from Statistics Netherlands were merged with a nationwide claims database, covering over 99% of the population. Inclusion criteria comprised LDDD diagnosis codes and relevant surgical codes. Practice variation was assessed at the level of postal code areas and hospital service areas (HSAs). Multivariable logistic regression analysis was employed to identify variables associated with surgical treatment. Among the 119,148 hospital visitors with LDDD, 14,840 underwent surgical treatment. Practice variation for laminectomies and discectomies showed less than two-fold variation in both postal code and HSAs. However, instrumented fusion surgery demonstrated a five-fold variation in postal code areas and three-fold variation in HSAs. Predictors of receiving surgical treatment included opioid prescription and patient referral status. Gender differences were observed, with males more likely to undergo laminectomy or discectomy, and females more likely to receive instrumented fusion surgery. Our study revealed low variation rates for discectomies and laminectomies, while indicating a high variation rate for instrumented fusion surgery in LDDD patients. High-quality research is needed on the extent of guideline implementation and its influence on practice variation.
Two-view topogram-based anatomy-guided CT reconstruction for prospective risk minimization
Authors: Liu Chang , Klein Laura , Huang Yixing , Baader Edith , Lell Michael , Kachelrieß Marc , Maier Andreas 
Published: April 2024

AbstractTo facilitate a prospective estimation of the effective dose of an CT scan prior to the actual scanning in order to use sophisticated patient risk minimizing methods, a prospective spatial dose estimation and the known anatomical structures are required. To this end, a CT reconstruction method is required to reconstruct CT volumes from as few projections as possible, i.e. by using the topograms, with anatomical structures as correct as possible. In this work, an optimized CT reconstruction model based on a generative adversarial network (GAN) is proposed. The GAN is trained to reconstruct 3D volumes from an anterior-posterior and a lateral CT projection. To enhance anatomical structures, a pre-trained organ segmentation network and the 3D perceptual loss are applied during the training phase, so that the model can then generate both organ-enhanced CT volume and organ segmentation masks. The proposed method can reconstruct CT volumes with PSNR of 26.49, RMSE of 196.17, and SSIM of 0.64, compared to 26.21, 201.55 and 0.63 using the baseline method. In terms of the anatomical structure, the proposed method effectively enhances the organ shapes and boundaries and allows for a straight-forward identification of the relevant anatomical structures. We note that conventional reconstruction metrics fail to indicate the enhancement of anatomical structures. In addition to such metrics, the evaluation is expanded with assessing the organ segmentation performance. The average organ dice of the proposed method is 0.71 compared with 0.63 for the baseline model, indicating the enhancement of anatomical structures.
Probing corporeal awareness in women through virtual reality induction of embreathment illusion
Authors: Cantoni Chiara , Salaris Andrea , Monti Alessandro , Porciello Giuseppina , Aglioti Salvatore Maria 
Published: April 2024

AbstractWe capitalized on the respiratory bodily illusion that we discovered in a previous study and called ‘Embreathment’ where we showed that breathing modulates corporeal awareness in men. Despite the relevance of the issue, no such studies are available in women. To bridge this gap, we tested whether the synchronization of avatar-participant respiration patterns influenced females’ bodily awareness. We collected cardiac and respiratory interoceptive measures, administered body (dis)satisfaction questionnaires, and tracked participants’ menstrual cycles via a mobile app. Our approach allowed us to characterize the ‘Embreathment’ illusion in women, and explore the relationships between menstrual cycle, interoception and body image. We found that breathing was as crucial as visual appearance in eliciting feelings of ownership and held greater significance than any other cue with respect to body agency in both women and men. Moreover, a positive correlation between menstrual cycle days and body image concerns, and a negative correlation between interoceptive sensibility and body dissatisfaction were found, confirming that women’s body dissatisfaction arises during the last days of menstrual cycle and is associated with interoception. These findings have potential implications for corporeal awareness alterations in clinical conditions like eating disorders and schizophrenia.
Identifying the causal relationship between immune factors and osteonecrosis: a two-sample Mendelian randomization study
Authors: Wang Chao , Zhu Yong , Pan Ding 
Published: April 2024

AbstractA wealth of evidence intimates a profound connection between the immune system and osteonecrosis, albeit the specific immune factors underlying this connection remain largely veiled. A bidirectional Mendelian randomization (MR) study was conducted based on genome-wide association study summary data to identify causal links between 731 immune factors and osteonecrosis including drug-induced osteonecrosis. Preliminary MR analysis was accomplished utilizing the inverse-variance weighted method under a multiplicative random effects model, and heterogeneity and potential horizontal pleiotropy were evaluated through Cochrane's Q-test, MR-Egger intercept test, MR-PRESSO global test, and leave-one-out analysis. Upon false discovery rate correction, the gene-predicted level of one immune factor (CD62L − monocyte %monocyte) exhibited a significant positive correlation with osteonecrosis, while eight immune traits associated with monocytes, dendritic cells, and NK cells demonstrated significant causal effects with drug-induced osteonecrosis. Reverse MR revealed no significant correlations. This MR research provides genetic evidence for the causal associations between a broad spectrum of immune factors and osteonecrosis. Such a study aids in unraveling the intricate interaction patterns between the immune and skeletal systems, elucidating the pathogenesis of osteonecrosis, and identifying potential novel therapeutic approaches.