bluuebunny/crossref_metadata_2025_split huggingface dataset:
PERCEPÇÕES DE ENFERMEIROS QUANTO À SISTEMATIZAÇÃO DA ASSISTÊNCIA DE ENFERMAGEM EM TERAPIA INTENSIVA
Authors: Romão Francisca Samila Pinto , Lemos Maria Cristiane Soares de , Carneiro Luziana de Paiva , Moraes Antonia Janielly Negreiros de , Viana Vanessa Araujo , Cisne Alana Freire 
Published: April 2024

A pesquisa teve como objetivo identificar o significado bem como os entraves da Sistematização de Enfermagem na Unidade de Terapia Intensiva, na percepção dos enfermeiros. Trata-se de um estudo descritivo, exploratório, de abordagem qualitativa, com análise de conteúdo de Bardin. A coleta de dados foi realizada por meio de entrevista semi-estruturada, com assinatura dos termos de consentimentos livre e esclarecido, realizadas em Maio de 2015 com dezessete enfermeiros assistencialistas nas Unidades de Terapia Intensiva do Hospital Santa Casa de Misericórdia de Sobral-CE, conforme aprovação do Comitê de Ética em Pesquisa da Escola de Saúde Pública do Ceará e mediante CAAE n. 43800415.0.0000.5037, recebendo parecer favorável para sua publicação sob Protocolo n. 1.055.916 . A partir das análises das entrevistas, emergiram quatro categorias a serem discutidas: Significado da Sistematização; Aplicação da SAE no dia-a-dia; Desafios enfrentados na utilização da Sistematização e Sugestões para Implantação da Sistematização. E como conclusão apesar dos enfermeiros reconhecerem o singular significado da Sistematização de enfermagem, sua aplicação na prática assistencial deixa muito a desejar e vários entraves contribuem para que isso ocorra, dentre eles carência de profissional de enfermagem capacitado; déficit na quantidade de enfermeiros no setor; excesso de atividades administrativo-burocráticas que sobrecarregam o enfermeiro.
The Neurons That Restore Walking After Paralysis
Authors: Editorial Staff  
Published: April 2024

Paralysis after a spinal cord injury is due to the cut-off signaling between the brain and brainstem, especially those pathways that lead to a lumbar spinal cord. Kathe and her colleagues demonstrated that walking in nine patients with spinal cord injury significantly improved during the neurorehabilitation process in which the lumbar spinal cord's spatiotemporal epidural electrical stimulation (EES) was used. A decrease in the lumber spinal cord neuronal activity was counterintuitively accompanied by improved human walking. The authors thought that this decrease in neuronal activity suggests the selection of a particular neuronal subpopulation essential for walking. To find this out, they recapitulated the same study in mouse models. They used transcriptomics and single-nucleus sequencing to chart the molecular circuitry of these mice from paralysis to recovery. They found a subset of neurons within the intermediate laminate. Interestingly, these neurons are not required for normal walking in healthy individuals, but the authors demonstrated that these neurons are essential for walking after a spinal injury. They further confirmed their findings by ablating these neurons, which prevented the recovery from a spinal injury, whereas augmenting these neurons further improved the recovery. The authors found a subset of neurons that organize the rescue of walking after spinal injury and provided a new framework for using molecular cartography to identify neurons required for certain behaviors. Nature (2022) DOI: https://doi.org/10.1038/s41586-022-05385-7.
Enhanced T cell Effector Activity by Targeting the Mediator Kinase Module
Authors: Editorial Staff  
Published: April 2024

T cells play important roles in combating various diseases, including cancers. To find out what genes hinder the function of T cells, Freitas and colleagues performed genome-wide CRISPR knock-out experiments in human chimeric antigen receptor T cells. They found that two genes, MED12 and CCNC, which are part of the Mediator kinase module, had the most significant effect. They discovered that antitumor activity was increased when MED12 was selectively deleted, and the effector phenotype was maintained in chimeric antigen receptor and T cell receptor-engineered T cells. They found increased occupancy of core Mediator chromatin at transcriptionally active enhancers in MED12-deficient cells. This effect was most evident for enhanced IL2RA expression and STAT and AP-1 transcription factors. The authors concluded that Mediator plays a vital role in T cell effector programming and that antitumor T cell response may be enhanced by targeting the Mediator kinase module. Science (2022). DOI: 10.1126/science.abn5647.
Dukungan Keluarga Pasien Paska Operasi terhadap Kepatuhan Pasien Selama Berada di Ruang Perawatan
Authors: Dame Panjaitan Junifer , Rahmah Vavi , Eka Septian Maliky Ezhar 
Published: April 2024

Setiap tindakan operasi memiliki karakteristik khusus, dan dampak paska operasi dapat bervariasi tergantung pada jenis operasi yang dilakukan. Untuk mempercepat kesembuhan pasien paska operasi, maka dibutuhkan kepatuhan berobat pada pasien paska operasi untuk memastikan pemulihan yang optimal dan mencegah komplikasi. Kepatuhan berobat adalah kewajiban pasien sesuai dengan UU no 17 th 2023 pasal 277 ayat b. Dan keluarga memiliki kewajiban untuk membantu pasien agar dapt mematuhi segala aturan yang diberikan oleh Rumah Sakit dan Tenaga Kesehatan sesuai dengan UU no 17 th 2023 pasal 5 ayat b bahwa : “Setiap orang berkewajiban menjaga dan meningkatkan derajat kesehatan bagi orang lain yang menjadi tanggungjawabnya.”. Namun terkadang, pemahaman keluarga pasien mengenai kewajiban ini masih rendah. Masih banyak keluarga yang mengabaikan kepatuhan terhadap aturan RS dan Nakes dengan alasan : pasien menolak, atau pasien menginginkan sesuatu yang tidak diperbolehkan secara aturan RS (seperti makanan), atau alasan kasihan terhadap kondisi pasien jika mengikuti aturan RS dan Nakes. Padahal dengan dukungan yang tepat, diharapkan pasien dapat mengikuti perawatan dengan lebih baik. Semakin pasien patuh menjalani perawatan akan semakin terhindar dari komplikasi penyakitnya. Adapun penulisan jurnal ini bertujuan untuk mengetahui hubungan antara dukungan keluarga dengan kepatuhan tentang pengobatan pasien paska operasi selama di ruang perawatan Rumah Sakit. Metode yang digunakan adalah metode penelitian hukum normatif yang dikolaborasikan dengan penelitian hukum empiris. Kesimpulan. Dukungan Keluarga sangat penting khususnya pada pasien paska operasi untuk menjalani proses pengobatan. Agar dapat mempercepat pemulihan pasien.
THE IMPACT OF BENIGN PROSTATE HYPERPLASIA TREATMENT MODALITIES ON THE INCIDENCE AND PROGRESSION OF URETHRAL STRICTURE : A COMPREHENSIVE SYSTEMATIC REVIEW
Authors: Dwitawira Wibowo Nanchita , Rizky Hidayat Muhammad 
Published: April 2024

Background: Urinary tract symptoms in elderly men are frequently caused by BPH, which frequently results in urethral stricture. Perioperative morbidity might result from surgical methods such as simple open prostatectomy and transurethral resection. Several techniques, such as HoLEP, have surfaced as novel therapies.
Methods: Following PRISMA 2020 guidelines, this systematic review concentrated on full-text English literature published between 2014 and 2024. Editorials and review articles that appeared in the same journal as the submission were not accepted without a DOI. The literature was assembled using a variety of online databases, including ScienceDirect, PubMed, and SagePub.
Result: The study utilized reliable sources like Science Direct, SagePub, and PubMed for screening over 500 publications. Six papers were identified as relevant for systematic analysis, followed by further study and examination of the complete document.
Conclusion: The treatment of BPH patients using the TURis system and TUEP is effective in preventing postoperative complications like urethral strictures. However, further large-scale multicentre RCTs are needed to confirm these findings. BMA is suitable for short proximal bulbar urethral strictures, and the inverted omega En-bloc HoLEP technique is safe and effective for all prostate sizes.
Impact of motor activity restriction on physical and psychological health
Authors: Святова Н.В. , Васенков Н.В. , Смелкова Е.В. 
Published: April 2024

в статье рассматриваются возможные проблемы и заболевания, которые могут быть вызваны в результате ограничения двигательной активности. Отмечается, что малоподвижный образ жизни оказывает влияние не только на физиологию, но и на психику человека. Цель исследования: анализ изменений в физическом и психологическом состоянии человека в процессе снижения его двигательной активности. Сделаны выводы: Из причин влияющих на ограничение двигательной активности студенты КГЭУ на первое место поставили увлечение социальными сетями – 73%, на второе наличие работы – 65%. Студенты КФ РГУП, так же как и студенты КГЭУ, считают, что увлечение соц. сетями является основной причиной ограничения двигательной активности. На втором месте у них – напряжённый учебный процесс.
the article discusses possible problems and diseases that can be caused as a result of restriction of physical activity. It is noted that a sedentary lifestyle affects not only physiology, but also the human psyche. The purpose of the study is to analyze changes in the physical and psychological state of a person in the process of reducing his motor activity. Conclusions: Of the reasons influencing the limitation of motor activity, KSPEU students put the hobby of social networks in the first place – 73%, the second – the availability of work – 65%. Students of the Faculty of Economics of the Russian State University of Economics, as well as students of KSPEU, believe that the hobby of social networks is the main cause of motor activity restriction. In second place for them is the intense educational process.
The study of historical figures in extracurricular activities
Authors: Мукин Д.П. 
Published: April 2024

в статье рассматриваются и выявляются методические аспекты раскрытия роли личности на школьном курсе всеобщей истории. Методические основы процесса освещения исторических деятелей охватывают требования к отбору и оформлению содержания учебного исторического материала и подходы к выбору и применению определенных средств и методов обучения во внеурочной деятельности. Определены современные теоретические проблемы преподавания истории в отечественной школе. Показаны приемы изучения главных фактов, воспроизведения образов исторических деятелей, событий и явлений в их жизни общества. Для повышения эффективности изучения исторических личностей во внеурочной деятельности предложены практические рекомендации по изучению таких личностей во внеурочной деятельности. Доказано, что разрабатывая и внедряя новые технологии по изучению исторических личностей во внеурочной деятельности, следует позаботиться о том, чтобы изменить отношение учащихся к учебной работе, стимулировать положительную мотивацию и стремление заниматься внеурочной работой с полной отдачей сил и творчества, обеспечить ситуацию успеха для каждого ученика.
the article examines and identifies methodological aspects of revealing the role of personality in the school course of universal history. The methodological foundations of the process of highlighting historical figures cover the requirements for the selection and design of the content of educational historical material and approaches to the selection and application of certain means and methods of teaching in extracurricular activities. The modern theoretical problems of teaching history in the national school are identified. The techniques of studying the main facts, reproducing images of historical figures, events and phenomena in their social life are shown. To increase the effectiveness of studying historical figures in extracurricular activities, practical recommendations for studying such personalities in extracurricular activities are proposed. It is proved that by developing and implementing new technologies for the study of historical figures in extracurricular activities, care should be taken to change the attitude of students to academic work, stimulate positive motivation and the desire to engage in extracurricular activities with full dedication and creativity, ensure a situation of success for each student.
The importance of functional literacy for students of pedagogical training areas
Authors: Пакина Т.А. , Ретивина В.В. 
Published: April 2024

цель исследования – выявить значение функциональной грамотности для студентов педагогических направлений подготовки. В статье отражен результат изучения особенностей процесса формирования функциональной грамотности обучающихся как одной из важных задач современной системы образования. Научная новизна исследования состоит в систематизации понятия функциональной грамотности и выявлении ее роли в становлении современного педагога. В результате проведенного анализа установлено, что особенно важным является развитие функциональной грамотности у студентов педагогических направлений подготовки в связи с тем, что именно педагоги вносят значительный вклад в обучение и воспитание подрастающих поколений грамотных, мотивированных, высококвалифицированных личностей. Большую роль в формировании функционально грамотной личности играет развитие соответствующих личностных и профессиональных компетенций.
the aim of the study is to identify the importance of functional literacy for students of pedagogical training areas. The article reflects the result of studying the features of the process of formation of functional literacy of students as one of the important tasks of the modern education system. The scientific novelty of the research consists in the systematization of the concept of functional literacy and the identification of its role in the formation of a modern teacher. As a result of the analysis, it was found that the development of functional literacy among students of pedagogical training areas is especially important due to the fact that it is teachers who make a significant contribution to the education and upbringing of the younger generations of literate, motivated, highly qualified individuals. An important role in the formation of a functionally literate personality is played by the development of appropriate personal and professional competencies.
Beneficios que ofrece el Método Tomatis para el desarrollo cognitivo de niños en edad escolar
Authors: Culqui Ceron Patricia Catherine 
Published: April 2024

Dr. Tomatis said "Sacred sound charge the cortex of the brain and stimulate health and wellness", his Tomatis Method is a type of auditory therapy whose function is to improve listening and communication skills, in addition its field of action is directed to voice, language, control of emotions, motor skills and coordination, language learning, Autism Spectrum Disorder and learning. The present research will be focused on the benefitsof this Audio-Psycho-Phonology for the treatment of children with learning difficulties; whose methodology used was with a quali-quantitative approach, exploratory level and mixed design. The results obtained show that the application of the method has a positive impact on the treatment of cognitive development and learning disorders in children through music and language, however it is a little known method in Ecuador and requires publicity actions to promote it.
Uji Efektivitas Ekstrak Dekok Daun Namnam (Cynometra cauliflora L.) Terhadap Penurunan Kadar Gula Darah Pada Tikus Putih Jantan (Rattus norvegicus) Yang Diinduksi Aloksan.
Authors: Dede Komarudin  , Reza Putri  , Reza Putri  
Published: April 2024

Namnam leaf (Cynometra cauliflora L.) is one of the plants that has medicinal properties. Various secondary metabolites, such as phenols and flavonoids, are thought to reduce blood glucose levels. The aim of this study was to determine the effectiveness of namnam leaf dekok extract (Cynometra cauliflora L.) on reducing blood sugar levels in male white rats (Rattus norvegicus) induced by alloxan. The study was an experimental study, using experiments on male white rats (Rattus norvegicus) using namnam leaf decoction extract (Cynometra cauliflora L.) and data obtained from measuring blood sugar using the microlab 200 levels were statistically analyzed using the One Way ANOVA SPSS 21 method to determine the existence the difference between the treatments. Based on the results obtained, it can be concluded that the extract of namnam leaf dekok (Cynometra cauliflora L.) has an effect in reducing blood sugar levels. The dose of namnam leaf dekok extract dose 3 showed the best reduction in blood sugar levels compared to dose 1 and dose 2. The most optimal dose was found at dose 3 namnam leaf dekok extract (Cynomtetra cauliflora L.). And based on the results of the study, the comparison drug used was metformin, and the dose that was almost as significant as the comparator drug was dose 3.
Қазіргі заман жеткіншектерінің өзіндік бағалау ерекшеліктері
Authors: Алматай Қуаныш , Умирзакова Гулзар 
Published: April 2024

Қазіргі қоғамдағы әлеуметтік-экономикалық өзгерістер келешек ұрпақтың тұлғалық қалыптасу процесі мен олардың әлеуметтік-психологиялық бейімделу деңгейіне айтарлықпай ықпал етуде. Бұл әсіресе ішкі қарама-қайшылықтармен сипатталатын жеткіншектік кезеңде орын алады.Жеткіншектік кезең өзіндік сана мен мінез-құлықтың қалыптасуы, өзіндік бағалау мен өзіндік қатынастың дербес, тәуелсіз жүйесінің өңделуі. Осындай жағдайлар дамудың осы кезеңіндегі өзіндік бағалау мәселесіне кеңінен тоқталуға негіз болды. Сонымен қатар, түрлі психологиялық және әлеуметтік факторлармен қатар, өзіндік бағалау баланың әлеуметтенуі мен қоғамдық мінез-құлық нормаларының қалыпты жүзеге асуына зор ықпал етеді.Мақалада қазіргі заман жеткіншектерінің тұлғалық дамуындағы психологиялық ерекшеліктеріне, «өзіндік бағалау» түсінігінің мәні, құрылымы мен қызметтеріне теориялық талдау жасалып, сол теориялық білімнің негізінде өзіндік бағалаудың құрылымдық үлгісі құрылды және оқыту мен тәрбиелеудің қазіргі жағдайындағы жеткіншектердің өзіндік бағалау ерекшеліктері анықталды. Соның негізінде 7-10 сынып оқушыларының өзіндік бағалау ерекшеліктері қарастырылды. Сонымен қатар, бұл ғылыми жұмыстың отбасында жеткіншектердің өзара қатынасы мен өзара түсіністігін жақсарту мақсатында және жеткіншектермен жұмыс істейтін педагогикалық кадрларды даярлау ісінде қолданылу қажеттілігі зор болып табылады.
Analysis on the impact of dynamic innovation investment strategy of green supply chain enabled by blockchain
Authors: Guo Fangfang , Wu Zhuang , Wang Yuanyuan , Liu Chenjun 
Published: April 2024

Background
The emergence of the green supply chain represents a natural evolution from the traditional model. However, this transition has created trust concerns in operational processes. Fortunately, blockchain technology offers a promising solution to address this issue and help businesses overcome related obstacles. As artificial intelligence and blockchain continue to advance, enterprises are increasingly exploring opportunities for green innovation investments, although the optimal timing for successful product innovation can be difficult to predict.

Methods
The effects of successful innovation on eco-friendly supply chains are analyzed through various factors such as optimal investment strategy, level of blockchain technology, and overall system profit. Differential game theory is used to determine the most effective approach across three alliance modes: horizontal cooperative, non-cooperative, and vertical cooperative. Additionally, the impact of innovation uncertainty on member strategies and alliance selection is thoroughly examined.

Results
According to the results, predicting the likelihood of innovation realization can influence decision makers to prioritize current profits. Both horizontal and vertical cooperative alliance models can lead to Pareto improvements in total system profit, both before and after innovation success. However, the vertical cooperative alliance model proves to be more effective, especially at higher realization rates. Green suppliers stand to benefit from the vertical cooperative alliance model, as it can enhance their innovative investment strategy, while platform cooperation does not significantly affect their strategy. Platforms, on the other hand, can benefit from the vertical cooperative alliance model, as it can promote their innovative investment strategy and level of blockchain technology.
Measurement of Phenylalanine Monooxygenase (PAH) Activities
Authors: Steventon Glyn B. , Mitchell Stephen C. 
Published: August 2009

AbstractMammalian phenylalanine monooxygenase (phenylalaninase, phenylalanine hydroxylase, PAH; EC 1.14.16.1) is a member of the large aromatic amino acid hydrolase cohort of enzymes that include tyrosine monooxygenase and tryptophane monooxygenase. PAH is a non‐heme‐iron‐dependent protein that normally catalyzes the C‐oxidation of phenylalanine (Phe) to tyrosine (Tyr) in the presence of BH4, utilizing molecular dioxygen as an additional substrate. However, over recent years, the presumed narrow substrate specificity of PAH has been questioned and catalytic activity towards alternative xenobiotic substrates (both environmental and drugs) has been reported. Like the cytochrome P450 system, PAH is able to oxidize both aliphatic and aromatic carbon centers in addition to undertaking the S‐oxidation of aliphatic thioethers (including the two mucoactive drugs S‐carboxymethyl‐L‐cysteine and S‐methyl‐L‐cysteine).Curr. Protoc. Toxicol. 41:4.29.1‐4.29.11. © 2009 by John Wiley & Sons, Inc.
Genotyping Escherichia coli O157:H7 for Its Ability to Cause Disease in Humans
Authors: Bono James L. 
Published: August 2009

AbstractEscherichia coli are ubiquitous in the world, and for the most part are non‐pathogenic and part of the normal lower gastrointestinal tract in mammals. However, some pathogenic isolates can cause severe disease that range from meningitis to hemorrhagic colitis (HC). In recent years, Shiga toxin‐containing E. coli (STEC) have been a major cause of food borne and environmental cases of HC and hemolytic uremic syndrome. One STEC serotype, O157:H7, has been responsible for numerous food‐associated outbreaks and recalls worldwide. The protocols in this unit will allow the reader to use real‐time polymerase chain reaction genotyping to identify isolates that are more likely to cause disease in humans. The genotyping assay targets a single‐nucleotide polymorphism (SNP) in the tir gene. The tir gene is located in a virulence operon called the locus for enterocyte effacement and functions as a receptor for the tight adherence of E. coli O157:H7 to epithelial cells. As more genomes are sequenced, informative SNPs that associate with phenotypes will be identified. Identifying isolates not only by their genus and species, but also by using other informative genomic traits will increase the general knowledge about their genetic diversity. Curr. Protoc. Microbiol. 14:5A.3.1‐5A.3.10. © 2009 by John Wiley & Sons, Inc.
Propagation of Major Plant‐Virus Hosts
Authors: Hull Roger 
Published: August 2009

AbstractPlant viruses are propagated in host plants, which are usually grown in glasshouses, screen houses, or growth cabinets. In most cases, the plants are grown from seed; in some cases, they are propagated as cuttings. This unit describes the basic techniques of growing suitable plants from seed and cuttings. Curr. Protoc. Microbiol. 14:16A.2.1‐16A.2.4. © 2009 by John Wiley & Sons, Inc.