bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of three types of alpha‐1 adrenoceptor blocker on lower urinary tract symptoms and sexual function in males with benign prostatic hyperplasia
Authors: Yokoyama Teruhiko , Hara Ryoei , Fukumoto Kazuhiko , Fujii Tomohiro , Jo Yoshimasa , Miyaji Yoshiyuki , Nagai Atsushi , Sone Atsushi 
Published: January 2011

Objectives:  The aim of the present study was to explore the effects of three different types of alpha‐1 adrenoceptor blockers (α1‐blocker) on lower urinary tract symptoms (LUTS), erectile dysfunction (ED) and ejaculatory dysfunction (EjD) in patients with benign prostatic hyperplasia.Methods:  A total of 136 male LUTS patients aged 50–80 years with International Prostate Symptom Score (IPSS) ≥8 were enrolled. They were divided into three groups. Group S received silodosin at 4 mg twice a day; group T received tamsulosin at 0.2 mg once a day; and group N received naftopidil at 50 mg once a day. Assessment included IPSS, quality of life indexes (QOL), International Index of Erectile Function (IIEF‐5), an ejaculation questionnaire, Qmax and post‐void residual urine volume (PVR). These parameters were recorded at baseline, and at 1 and 3 months after treatment had ended.Results:  Mean IPSS and Qmax significantly improved after treatment in all groups without any significant difference among them. As for the IIEF‐5 score, only group N significantly improved at 1 and 3 months. After treatment, 2.6 and 2.4% of patients complained of a de novo reduced volume of ejaculation in both groups T and N, respectively. Ten out of 41 patients (24.4%) complained of a total absence of antegrade ejaculation in group S after treatment.Conclusions:  All three types of α1‐blockers provided an objective and subjective improvement of LUTS in the present study population. However, erectile function only improved in patients treated with naftopidil and a higher rate of EjD was observed in those receiving silodosin. Because of their variable effects, we should consider the sexual dimension when prescribing α1‐blockers for LUTS.
Incidence of osteoradionecrosis of the temporal bone
Authors: Morrissey David , Grigg Roger 
Published: January 2011

AbstractBackground: Osteoradionecrosis of the temporal bone is a serious, late complication of radiotherapy to the temporal bone region. The aim of this study was to determine the incidence, risk and protective factors relating to the development of osteoradionecrosis of the temporal bone.Methods: This is a retrospective review of prospectively collected data. A single surgeon collated a database over a 10‐year period regarding patients undergoing surgery and subsequent radiotherapy for head and neck malignancies. This was reviewed, and information pertaining to demographics, nature of disease, radiation treatment regime and complications including osteoradionecrosis was extracted. Statistical analysis was then completed independently.Results: A total of seven patients from the cohort of 82 developed osteoradionecrosis of the temporal bone within the period of the data collection. This represents an incidence of 8.5% (95% confidence interval = 3.6–13.4%). All who developed osteoradionecrosis had a metastatic parotid squamous cell carcinoma treated operatively with subsequent radiotherapy. There were no statistically significant risks or prognostic factors identified. Mean duration of follow‐up was 32 months.Conclusion: The incidence of osteoradionecrosis of the temporal bone was 8.5% (95% confidence interval = 3.6–13.4%). Osteoradionecrosis of the temporal bone can present in excess of 10 years after treatment completion. This result may actually under ‐represent the true incidence of the complication. It has significant morbidity associated with its development and, occasionally, mortality. Those people undergoing radiotherapy to the parotid region may be at higher risk of osteoradionecrosis. A new classification system for osteoradionecrosis of the temporal bone has been proposed.
Solitary metastasis of a clear cell ovarian adenocarcinoma to the small bowel mucosa
Authors: Nakamura Miwa , Mitsuhashi Akira , Tanaka Naotake , Nagai Yuichiro , Shozu Makio 
Published: January 2011

AbstractMetastasis of ovarian carcinoma to the small bowel parenchyma without peritoneal dissemination is uncommon. A 63‐year‐old woman underwent surgery for a clear cell adenocarcinoma of the ovary and received adjuvant chemotherapy. Eighteen months after the operation, she presented with recurrent occult bowel hemorrhage without evidence of an abdominal mass. Nine months later, a rapidly growing abdominal mass was detected. Laparoscopy revealed a solitary tumor of the ileum covered with an intact serosal layer. Partial ileectomy was performed for tumor resection. Histological examination revealed cells resembling the primary ovarian tumor in the mucosal surface of the small bowel along with an intact serosa. The tumor cells were positive for cytokeratin 7 and negative for cytokeratin 20, suggesting an ovarian origin. This is the first report of solitary metastasis of an ovarian carcinoma to the small bowel parenchyma without peritoneal dissemination. Metastasis to the small bowel should be considered in ovarian carcinoma patients with occult gastrointestinal hemorrhage.
Factors affecting surgical margins in nonpalpable breast tumors excised with the radioguided occult lesion localization approach
Authors: del Mar Vernet‐Tomas María , Ortega Marisa , Vidal Sergi , Corominas José M. , Carreras Ramon 
Published: January 2011

AbstractAim:  Most breast surgeons generally assume that obtaining negative margins in nonpalpable tumors is a matter of concern. The aim of this study was to examine whether it is easier to obtain negative margins in palpable tumors than in nonpalpable tumors excised with the radioguided occult lesion localization (ROLL) technique.Methods:  A retrospective review was made of nonpalpable breast cancers excised with the ROLL technique (ROLL group, n = 83) and palpable breast cancers in which breast conservative therapy was performed (Palpable group, n = 77). The margin status and the size of the minimum margin obtained when it was negative were reviewed.Results:  The percentage of resections with negative margins was similar in both groups: 51.9% in the Palpable group and 61.4% in the ROLL group. There was no difference between the two groups in the minimum margin obtained: mean ± SD, 5.53 ± 3.146 mm in the Palpable group and 5.96 ± 3.039 mm in the ROLL group. Risk factors for failing to obtain negative margins were analyzed in both groups and were similar. These risk factors included histological grade, extensive intraductal carcinoma and c‐erbB2 status.Conclusion:  It is concluded that excision of nonpalpable breast tumors with the ROLL approach obtains similar results for margins as conservative surgery performed for palpable tumors.
Assisted reproductive technologies in Thailand: 2001–2007 results generated from the ART Registry, Royal Thai College of Obstetricians and Gynaecologists
Authors: Vutyavanich Teraporn , Piromlertamorn Waraporn , Ellis Jason ,   On Behalf of the Reproductive Medicine Subcommittee, The Royal Thai College of Obstetricians and Gynaecologists
Published: January 2011

AbstractAim:  To present the results of assisted reproductive technology (ART) performed in Thailand during 2001–2007.Methods:  All licensed ART centers are obliged to submit annual reports on the number of patients, cycles, ART techniques and treatment outcomes to the Reproductive Medicine Subcommittee of the Royal Thai College of Obstetricians and Gynaecologists. Data from all centers were aggregated and analyzed retrospectively.Results:  Cycles were categorized into fresh and frozen/thawed embryo transfer (FET) cycles. Initiated cycles in the first category for 2001 to 2007 were 2183, 2112, 2780, 2717, 3458, 3579 and 4288, respectively. FET cycles during the same period were 467, 558, 733, 768, 1136, 1210 and 1473, respectively. The average pregnancy rate for in vitro fertilization (IVF) was 28.9% per retrieval (range, 26–32.3%) or 33.8% per transfer (range, 30.7–38.6%). Multiple pregnancies (of which 89.3% were twins) from all treatment procedures during this period were 11.4% (range, 9.2–14.5%). A congenital abnormality was reported in 0.56% of live births. The number of embryos per transfer in IVF decreased from 4.1 to 2.9, with no drop in pregnancy rates. Oocyte insemination by intracytoplasmic sperm injection (ICSI) was utilized more often than standard IVF, while gamete intrafallopian transfer and zygote intrafallopian transfer were almost completely replaced by IVF/ICSI. There was a significant difference in pregnancy rates (P < 0.01) when clinics were classified by cycle volumes (<100, 100–400 and >400 cycles/year).Conclusions:  Despite many limitations, the data provided in this report will help patients, clinicians and policy makers understand the current situation of ART practice in Thailand.
Arranged Marriages as Support for Intra‐ethnic Matchmaking? A Case Study on Muslim Migrants in Germany
Authors: Hense Andrea , Schorch Marén 
Published: January 2011

AbstractThis article discusses the behavioural and institutional mechanisms that guide the matchmaking process of arranged marriages1 amongst Muslim migrants in Germany and clarifies how this practice may influence ethnic homogamy. The focus is on general characteristics of arranged marriages rather than differences between diverse ethnic groups. The methodology is qualitative due to the sensitive and complex topic and the current state of research. Typically, the whole family is deeply involved in the process of arrangement, which consists of three stages (pre‐engagement, engagement, marriage). Thereby, the extension of parental scope of action by means of institutionalized admission procedures turns out to be vitally important. In consideration of the fact that mate selection takes place at the pre‐engagement stage, it is the most crucial. Furthermore, differences to other partner‐choosing processes are at their most distinct at this point, being responsible for the identification and labelling of this model as an arranged marriage. Selection criteria are mainly determined by the reputation of the marriage candidate and her/his family along with cultural features (such as belonging to a particular religious group, ethnicity or nationality). In our study, preferences for a cultural homogenous match were the most dominant ones. This inclination may cause the tendency towards transnational marriages when there are no suitable marriage candidates to be found in Germany.
Evaluation of algorithms for the diagnostic assessment and the reentry of blood donors who tested reactive for antibodies against hepatitis B core antigen
Authors: Juhl David , Luhm Jürgen , Görg Siegfried , Ziemann Malte , Hennig Holger 
Published: January 2011

BACKGROUND: Screening of blood donations for antibodies against hepatitis B core antigen (anti‐HBc) is an accepted method to prevent some transfusion‐transmitted hepatitis B virus (HBV) infections. However, anti‐HBc testing may result in donor loss due to unspecific results in the currently available anti‐HBc tests. Algorithms to distinguish true‐positive from false‐positive results and for reentry of those donors who tested false anti‐HBc positive were evaluated retrospectively.STUDY DESIGN AND METHODS: Samples that tested reactive for anti‐HBc by chemiluminescent microparticle immunoassay (CMIA) were investigated for anti‐HBc by microparticle immunoassay, for anti‐HBs and hepatitis B surface antigen (HBsAg) by CMIA, and for HBV DNA by individual‐donor nucleic acid testing. Results were classified true positive, indeterminate, and false positive for anti‐HBc. Donors who tested indeterminate and false positive were admitted for reentry if follow‐up testing for anti‐HBc became negative and no further evidence for an HBV infection was apparent.RESULTS: A total of 554 of 148,000 samples, taken from 30,000 individuals within 3 years tested reactive for anti‐HBc by CMIA. Of those, 553 could be further classified: 142 (26%) true positive, 76 (14%) indeterminate, and 335 (60%) false positive. A total of 214 of 411 (52%) samples termed indeterminate or false positive were admitted for reentry and able to provide further donations. In one donor, anti‐HBc–positive/HBsAg‐ and HBV DNA–negative HBV DNA was detectable during follow‐up.CONCLUSION: According to our proposed algorithm, 26% of anti‐HBc–reactive results tested by CMIA were true positive. Many donors tested indeterminate or false positive can provide future donations if our proposed algorithm for reentry is applied. One donor at risk for transmitting HBV was identified solely by anti‐HBc testing.
Qualification of a new and precise automatic tool for the assessment of hair diameters in phototrichograms
Authors: Scheede Stefan , Herpens Andreas , Burmeister Frank , Oltrogge Bernhard , Saenger K. , Schmidt‐Rose Thomas , Schreiner Volker , Wenck Horst , Knieps Torsten , Berlage Thomas 
Published: January 2011

Background/purpose: To automatically assess hair growth during cosmetic trials, incorporating parameters such as anagen‐to‐telogen rate, growth rate, and especially hair diameter.Methods: We designed and qualified a new and automatic phototrichogram system based on a high‐resolution DSLR camera system (theoretical resolution of 2.557 μm/pixel) and modular macrolens system with fixed focus, combined with a trainable pattern recognition software for automated analysis.Results: We improved the standard routine for dermatological phototrichogram technique to overcome inaccuracy in thickness measurements due to hair swelling by using an alternative immersion fluid, and increased the effective resolution for hair size and thickness measurement to <4 μm. After having qualified manual measurements as gold standard for the determination of hair diameters, we established a new trainable automatic picture analysis software able to locate and measure individual hairs in length and thickness even in picture series taken from the same skin area at different time points. Comparisons between manual and automatic measurements of the same hairs showed a >90% correlation, and by comparing the automatic results with manual measurements of the same images without individual hair annotation, we could find a correlation of at least 80%.Conclusion: According to the results and findings generated in this qualification study, we have a reliable tool now that enables us to test cosmetic products for hair treatment in a highly automated way with a sufficient degree of precision and accuracy to detect even small changes in hair diameter during cosmetic trials.
An indicator framework for the climatic adaptive capacity of natural ecosystems
Authors: Czúcz Bálint , Csecserits Anikó , Botta‐Dukát Zoltán , Kröel‐Dulay György , Szabó Rebeka , Horváth Ferenc , Molnár Zsolt 
Published: January 2011

AbstractQuestions: Can the climatic adaptive capacity of natural ecosystems be estimated with using landscape indicators based on vegetation or land‐cover data? Can species distribution model (SDM) outputs be enhanced using such indicators? What are the data requirements and optimal parameter values of potential indicators?Location: Indicator framework: unspecified. Case study: Kiskunság, Hungary.Methods: (1) We define a general framework for handling adaptation in ecological climate change impact assessments based on IPCC definitions. (2) As a part of this general framework, we propose an indicator framework consisting of two specific indicators (landscape connectivity and landscape diversity index) to estimate adaptive capacity of ecosystems to climate change. (3) Using old‐field regeneration as a proxy process, we test the proposed indicators, perform sensitivity analysis to optimize them and detect limits of their applicability.Results: Landscape metrics could provide significant information on regeneration success of old‐fields. A combination of large‐scale connectivity and local diversity had the highest explanatory power, with connectivity being clearly superior. The tested indicator framework can be applied on the basis of commonly available land‐cover data sets. Ecological factors (like dispersal distances) are more important determinants of indicator performance than technical parameters or data resolution, provided minimum data quality is given. The dispersal distance of characteristic species of the Kiskunság forest–steppe region was ∼1 to 8 km during the last one to four decades.Conclusions: The results convincingly show that relatively simple and tractable metrics can effectively indicate the landscape‐specific capacity of ecosystems to adjust to climatic changes. We argue that the use of adaptive capacity indicator frameworks consisting of simple but ecologically meaningful indicators should accompany every policy‐oriented SDM study.
Quantomo: Validation of a Computer-Assisted Methodology for the Volumetric Analysis of Intracerebral Haemorrhage
Authors: Kosior Jayme C. , Idris Sherif , Dowlatshahi Dar , Alzawahmah Mohamed , Eesa Muneer , Sharma Pranshu , Tymchuk Sarah , Hill Michael D. , Aviv Richard I. , Frayne Richard , Demchuk Andrew M. ,   for the PREDICT/Sunnybrook CTA ICH study investigators
Published: January 2011

Background Volume measurements of intracerebral haemorrhage are prognostically important and are increasingly used in clinical trials to measure the effects of potential interventions. The purpose of this work is to establish the reliability of haematoma volume measurements obtained using a computer-assisted method called Quantomo (for quantitative tomography) and the ABC/2 method. Hypothesis Quantomo reliably detects smaller changes in intracerebral haemorrhage volume as compared with the ABC/2 method because computer-assisted volume measurements are tailored to measure the geometry of individual haematoma volumes whereas the ABC/2 method approximates all haematoma volumes as ellipsoids. Methods Thirty randomly selected computed tomography scans with intracerebral haemorrhage were measured by four raters a total of four times each (two sessions using Quantomo and two using the ABC/2 method). Interrater and intrarater reliability for both techniques were calculated simultaneously using a two-way random-effects analysis of variance model. The precision of intracerebral haemorrhage volume measurement was quantified as the minimum detectable difference with 95% confidence intervals. Results The median (first quartile and third quartile) intracerebral haemorrhage volume measurements of all rater and sessions for Quantomo were 32·7 ml (6·2 and 54·4 ml) and for ABC/2 40·7 ml (8·6 and 76·0 ml). Quantomo intracerebral haemorrhage volume measurements were more precise, having an inter- and intrarater minimum detectable difference of 8·1 and 5·3 ml, while the inter- and intrarater minimum detectable difference for ABC/2 were 37·0 and 15·7 ml. Conclusions Quantomo is a computer-assisted methodology that is more reliable for quantifying intracerebral haemorrhage volume as compared with the ABC/2 method.
Algorithms of Common Solutions to Generalized Mixed Equilibrium Problems and a System of Quasivariational Inclusions for Two Difference Nonlinear Operators in Banach Spaces
Authors: Onjai-uea Nawitcha , Kumam Poom 
Published: January 2011

AbstractWe consider a new iterative algorithm for finding a common element of the set of generalized mixed equilibrium problems, the set of solutions of a system of quasivariational inclusions for two difference inverse strongly accretive operators, and common set of fixed points for strict pseudo-contraction mappings in Banach spaces. Furthermore, strong convergence theorems of this method were established under suitable assumptions imposed on the algorithm parameters. The results obtained in this paper improve and extend some results in the literature.
Identification of Peroxiredoxin-1 as a Novel Biomarker of Abdominal Aortic Aneurysm
Authors: Martinez-Pinna Roxana , Ramos-Mozo Priscila , Madrigal-Matute Julio , Blanco-Colio Luis M. , Lopez Juan A. , Calvo Enrique , Camafeita Emilio , Lindholt Jes S. , Meilhac Olivier , Delbosc Sandrine , Michel Jean-Baptiste , de Ceniga Melina Vega , Egido Jesus , Martin-Ventura Jose L. 
Published: January 2011

Objective—
In the search of novel biomarkers of abdominal aortic aneurysm (AAA) progression, proteins released by intraluminal thrombus (ILT) were analyzed by a differential proteomic approach.

Methods and Results—
Different layers (luminal/abluminal) of the ILT of AAA were incubated, and the proteins released were analyzed by 2-dimensional difference in-gel electrophoresis. Several differentially expressed proteins involved in main AAA pathological mechanisms (proteolysis, oxidative stress, and thrombosis) were identified by mass spectrometry. Among the proteins identified, peroxiredoxin-1 (PRX-1) was more released by the luminal layer compared with the abluminal layer of the ILT, which was further validated by Western blot, ELISA, and immunohistochemistry. We demonstrated increased PRX-1 serum levels in AAA patients compared with healthy subjects and also positive correlation among PRX-1 and AAA diameter, plasmin-antiplasmin, and myeloperoxidase levels. Finally, a prospective study revealed a positive correlation between PRX-1 serum levels and AAA expansion rate. Moreover, the combination of PRX-1 and AAA size had significantly additive value in predicting growth.

Conclusion—
Several proteins associated with AAA pathogenesis have been identified by a proteomic approach in ILT-conditioned medium. Among them, PRX-1 serum levels are increased in AAA patients and correlate with AAA size and growth rate, suggesting the potential use of PRX-1 as a biomarker for AAA evolution.
Primary Monocytes Regulate Endothelial Cell Survival Through Secretion of Angiopoietin-1 and Activation of Endothelial Tie2
Authors: Schubert Shai Y. , Benarroch Alejandro , Monter-Solans Juan , Edelman Elazer R. 
Published: January 2011

Objective—
Monocyte recruitment and interaction with the endothelium is imperative to vascular recovery. Tie2 plays a key role in endothelial health and vascular remodeling. We studied monocyte-mediated Tie2/angiopoietin signaling following interaction of primary monocytes with endothelial cells and its role in endothelial cell survival.

Methods and Results—
The direct interaction of primary monocytes with subconfluent endothelial cells resulted in transient secretion of angiopoietin-1 from monocytes and the activation of endothelial Tie2. This effect was abolished by preactivation of monocytes with tumor necrosis factor-α. Although primary monocytes contained high levels of both angiopoietin 1 and 2, endothelial cells contained primarily angiopoietin 2. Seeding of monocytes on serum-starved endothelial cells reduced caspase-3 activity by 46±5.1%, and 52±5.8% after tumor necrosis factor-α treatment and decreased detected single-stranded DNA levels by 41±4.2% and 40±3.5%, respectively. This protective effect of monocytes on endothelial cells was reversed by Tie2 silencing with specific short interfering RNA. The antiapoptotic effect of monocytes was further supported by the activation of cell survival signaling pathways involving phosphatidylinositol 3-kinase, STAT3, and AKT.

Conclusion—
Monocytes and endothelial cells form a unique Tie2/angiopoietin-1 signaling system that affects endothelial cell survival and may play critical a role in vascular remodeling and homeostasis.