bluuebunny/crossref_metadata_2025_split huggingface dataset:
Rethinking Parkinson's disease: could dopamine reduction therapy have clinical utility?
Authors: Sackner-Bernstein Jonathan 
Published: June 2024

AbstractFollowing reports of low striatal dopamine content in Parkinson’s disease, levodopa was shown to rapidly reverse hypokinesis, establishing the model of disease as one of dopamine deficiency. Dopaminergic therapy became standard of care, yet it failed to reverse the disease, suggesting the understanding of disease was incomplete. The literature suggests the potential for toxicity of dopamine and its metabolites, perhaps more relevant given the recent evidence for elevated cytosolic dopamine levels in the dopaminergic neurons of people with Parkinson’s. To understand the relevance of these data, multiple investigations are reviewed that tested dopamine reduction therapy as an alternative to dopaminergic agents. The data from use of an inhibitor of dopamine synthesis in experimental models suggest that such an approach could reverse disease pathology, which suggests that cytosolic dopamine excess is a primary driver of disease. These data support clinical investigation of dopamine reduction therapy for Parkinson’s disease. Doing so will determine whether these experimental models are predictive and this treatment strategy is worth pursuing further. If clinical data are positive, it could warrant reconsideration of our disease model and treatment strategies, including a shift from dopaminergic to dopamine reduction treatment of the disease.
Die nicht-ärztliche onkologische und hämatologische Pflegesprechstunde
Authors: Kaiser Ulrich , Kaiser Florian , Damnali Gamze , Vehling-Kaiser Ursula 
Published: June 2024

ZusammenfassungDie Versorgung von Patienten mit malignen Erkrankungen wird mit der kontinuierlichen Entwicklung neuer Therapieformern und insbesondere oraler Therapien zunehmend komplexer. Eine kontinuierliche und hochqualifizierte Überwachung ist in zunehmendem Maße erforderlich. Um diesem Anspruch auch in Zukunft gerecht zu werden, stellt die verstärkte Einbindung nicht-ärztlichen Fachpersonals in die Versorgung der Tumorpatienten eine wichtige Option dar. Hierfür existieren aktuell bereits mehrere Modelle. Im vorliegenden Beitrag soll beispielhaft ein solches Modell, nämlich die nicht-ärztliche onkologische und hämatologische Pflegesprechstunde, unter Berücksichtigung von existierender Literatur und Erfahrungswerten der Autoren präsentiert werden. Zusammenfassend stellen folgende Gesichtspunkte die wesentlichen Ziele einer nicht-ärztlichen onkologischen und hämatologischen Pflegesprechstunde dar: Erläuterung der jeweiligen Therapieform einschließlich des Nebenwirkungsmanagements; Adhärenzkontrolle; soziale Aspekte und organisatorische Aspekte. Neben der fachlichen Qualifikation der Mitarbeiter, die die Pflegesprechstunde durchführen, müssen auch strukturelle Voraussetzungen zur erfolgreichen Durchführung der Pflegesprechstunde erfüllt werden. Obschon aktuell keine zusätzliche Vergütung der nicht-ärztlichen onkologischen und hämatologischen Pflegesprechstunde vorgesehen ist, hat diese Versorgungsform durchaus das Potenzial, ein fester Bestandteil vor allem der ambulanten Versorgung von Tumorpatienten zu werden und diese sinnvoll zu ergänzen.
Performance enhancement of a vortex ring thruster by adopting the Coanda effect
Authors: Seok Woochan , Heo Young Min , Rhee Shin Hyung 
Published: June 2024

AbstractA vortex ring thruster (VRT) is a propulsion device in which a piston pushes fluid and thrusts it in reaction. As the fluid inside a VRT is moving, the boundary layer near the wall at the edge of the exit surface of a VRT separates and rolls up into a vortex ring. In this paper, we performed performance analysis on a regular VRT and a VRT enhanced by the Coanda effect (hereafter referred to as a CoVoRT) on axisymmetric geometry. A CoVoRT consists of two jets: a primary jet and a Coanda jet. The primary jet has a relatively large volume flow rate compared to the Coanda jet, and the Coanda jet attracts the surrounding fluid by flowing along the curved surface at a relatively small flow rate. The present study evaluates the propulsion performance in two ways using SNUFOAM. This software was developed based on OpenFOAM, which is an open-source computational fluid dynamics (CFD) toolkit and specialized for naval hydrodynamics. The first one quantifies the propulsion performance by calculating the ratio of energy input and energy output generated by two jets during a stroke of the piston motion. The second one is to observe the evolution and pinch-off process of a vortex ring with formation time, which is a non-dimensional time scale. The comparison of propulsion performance was conducted with changes in the curvature of the Coanda jet, changes in the length of the Coanda jet exit, and changes in the Coanda jet velocity and piston stroke ratio. For quantitative evaluation of propulsion performance, the propulsion performance evaluation index (PPEI) was introduced. The results showed that the PPEI of a CoVoRT was improved by about 50% compared to that of a VRT, and it was confirmed that the dynamic characteristics of a CoVoRT’s vortex ring were superior to those of a VRT in terms of propulsion performance.
Introducing an innovative surgical technique: gluteal turnover flap for posterior vaginal wall reconstruction: a case series
Authors: Kreisel S. I. , van den Braak Robert R. J. Coebergh , Rothbarth J. , Musters G. D. , Tanis P. J. 
Published: June 2024

AbstractFour patients with rectal cancer required reconstruction of a defect of the posterior vaginal wall. All patients received neoadjuvant (chemo)radiotherapy, followed by an en bloc (abdomino)perineal resection of the rectum and posterior vaginal wall. The extent of the vaginal defect necessitated closure using a tissue flap with skin island. The gluteal turnover flap was used for this purpose as an alternative to conventional more invasive myocutaneous flaps (gracilis, gluteus, or rectus abdominis). The gluteal turnover flap was created through a curved incision at a maximum width of 2.5 cm from the edge of the perineal wound, thereby creating a half-moon shape skin island. The subcutaneous fat was dissected toward the gluteal muscle, and the gluteal fascia was incised. Thereafter, the flap was rotated into the defect and the skin island was sutured into the vaginal wall defect. The contralateral subcutaneous fat was mobilized for perineal closure in the midline, after which no donor site was visible.The duration of surgery varied from 77 to 392 min, and the hospital stay ranged between 3 and 16 days. A perineal wound dehiscence occurred in two patients, requiring an additional VY gluteal plasty in one patient. Complete vaginal and perineal wound healing was achieved in all patients. The gluteal turnover flap is a promising least invasive technique to reconstruct posterior vaginal wall defects after abdominoperineal resection for rectal cancer.
Socio-emotional behavior, learning, and the distinct contributions of Executive Functions in primary graders
Authors: Ruffini Costanza , Bei Eva , Pecini Chiara 
Published: June 2024

AbstractSocio-emotional school behavior and learning are both fundamental aspects of children’s development influenced by cognitive control processes named Executive Functions (EF). Yet, research on school-age children has often focused on the relationship between EF and learning skills overlooking that of EF and school behavior, which has usually been examined among preschoolers. The current study investigated the contribution of EF in both school behavior and learning in school-age children. One hundred forty-six III–V graders were assessed using text comprehension and EF tasks and evaluated by teachers-rated inventories on behavioral difficulties and EF within the school context. The results suggested a different involvement of direct and indirect EF measures in the two domains considered: controlling for socioeconomic level and age, an EF direct measure, predicted reading comprehension whereas teacher-reported EF related to both behavior and text comprehension. The results contribute to defining the role of cognitive control processes on school behavior and learning in school-age children.
Random forest with differential privacy in federated learning framework for network attack detection and classification
Authors: Markovic Tijana , Leon Miguel , Buffoni David , Punnekkat Sasikumar 
Published: June 2024

AbstractCommunication networks are crucial components of the underlying digital infrastructure in any smart city setup. The increasing usage of computer networks brings additional cyber security concerns, and every organization has to implement preventive measures to protect valuable data and business processes. Due to the inherent distributed nature of the city infrastructures as well as the critical nature of its resources and data, any solution to the attack detection calls for distributed, efficient and privacy preserving solutions. In this paper, we extend the evaluation of our federated learning framework for network attacks detection and classification based on random forest. Previously the framework was evaluated only for attack detection using four well-known intrusion detection datasets (KDD, NSL-KDD, UNSW-NB15, and CIC-IDS-2017). In this paper, we extend the evaluation for attack classification. We also evaluate how adding differential privacy into random forest, as an additional protective mechanism, affects the framework performances. The results show that the framework outperforms the average performance of independent random forests on clients for both attack detection and classification. Adding differential privacy penalizes the performance of random forest, as expected, but the use of the proposed framework still brings benefits in comparison to the use of independent local models. The code used in this paper is publicly available, to enable transparency and facilitate reproducibility within the research community.
Do White Women Gain Status for Engaging in Anti-black Racism at Work? An Experimental Examination of Status Conferral
Authors: Berdahl Jennifer L. , Bhattacharyya Barnini 
Published: June 2024

AbstractBusinesses often attempt to demonstrate their commitment to diversity, equity, and inclusion (DEI) by showcasing women in their leadership ranks, most of whom are white. Yet research has shown that organizations confer status and power to women who engage in sexist behavior, which undermines DEI efforts. We sought to examine whether women who engage in racist behavior are also conferred relative status at work. Drawing on theory and research on organizational culture and intersectionality, we predicted that a white woman who expresses anti-Black racism is conferred more status in the workplace than a white woman who does not. A pilot study (N = 30) confirmed that making an anti-Black racist comment at work was judged to be more offensive than making no comment, but only for a white man, not a white woman. Study 1 (N = 330) found that a white woman who made an anti-Black racist comment at work was conferred higher status than a white woman who did not, whereas the opposite held true for a white man, with perceived offensiveness mediating these effects. Study 2 (N = 235) revealed that a white woman who made an anti-racist/pro-Black Lives Matter comment was conferred lower status than a white woman who did not, whereas the opposite held true for a white man. Finally, Study 3 (N = 295) showed that people who endorse racist and sexist beliefs confer more status to a white man than to a white woman regardless of speech, but that people low in racism and sexism confer the highest status to a white woman who engages in anti-Black racist speech. These studies suggest that white women are rewarded for expressing support for beliefs that mirror systemic inequality in the corporate world. We discuss implications for business ethics and directions for future research.
Coronary artery calcium quantification technique using dual energy material decomposition: a simulation study
Authors: Black Dale , Singh Tejus , Molloi Sabee 
Published: June 2024

AbstractCoronary artery calcification is a significant predictor of cardiovascular disease, with current detection methods like Agatston scoring having limitations in sensitivity. This study aimed to evaluate the effectiveness of a novel CAC quantification method using dual-energy material decomposition, particularly its ability to detect low-density calcium and microcalcifications. A simulation study was conducted comparing the dual-energy material decomposition technique against the established Agatston scoring method and the newer volume fraction calcium mass technique. Detection accuracy and calcium mass measurement were the primary evaluation metrics. The dual-energy material decomposition technique demonstrated fewer false negatives than both Agatston scoring and volume fraction calcium mass, indicating higher sensitivity. In low-density phantom measurements, material decomposition resulted in only 7.41% false-negative (CAC = 0) measurements compared to 83.95% for Agatston scoring. For high-density phantoms, false negatives were removed (0.0%) compared to 20.99% in Agatston scoring. The dual-energy material decomposition technique presents a more sensitive and reliable method for CAC quantification.
Affective Discernment as a Boundary Experience
Authors: Turcan Nicolae 
Published: June 2024

AbstractThis article is a theo-phenomenological study on discernment in Eastern Orthodox spirituality, particularly as it is described in the Philokalia and the Apophthegmata Patrum. The article focuses on two fundamental dimensions: firstly, discernment as both theoretical and practical wisdom, characterized by the importance of preliminary discernment criteria; secondly, discernment as a spiritual gift of the Holy Spirit, which can be interpreted phenomenologically through the figure of the saturated phenomenon. In its concluding sections, the article proposes a new approach to religious thought, termed “diacritical thought”. This innovative approach evolves from objective thought, grounded in value criteria and contextual understanding, towards relational thought. It emphasizes affectivity and the importance of engaging with others, ultimately leading to prayer and mystical experiences. Throughout these stages, discernment undergoes a transformation: it evolves from a poor phenomenon into a saturated phenomenon, going on a journey from ordinary experience to testing the boundaries of human experience.
A new perspective on the molecular dating of the stone crayfish with an extended phylogeographic information on the species
Authors: Stanković David , Zorić Katarina , Đuretanović Simona , Stamenković Gorana , Ilić Marija , Marković Vanja , Marić Saša 
Published: June 2024

AbstractReconstructing the origin and historical biogeography of the Austropotamobius torrentium is hampered by insufficient phylogeographic coverage of the Balkans and deep contradictions in previous molecular dating. The present work extends the phylogeographic coverage to Serbia, a country crucial for understanding the species southward dispersal. Our analysis revealed that the Southern Balkans lineage occurs in most of the country, the Central and southeastern Europe lineage is restricted to the southwest and northeast of the country, while a single population in the north of the country harbors the Lika and Dalmatia lineage, which was previously thought to be restricted to the northern-central Dinarides. Dataset expansion led to revised phylogenetic relationships, which indicated that the Apuseni lineage is not nested within Northern-central Dinarides lineages but arose after the most basal split within Austropotamobius torrentium. This ‘Apuseni first’ phylogeny provides a new perspective for molecular dating, according to which the split between Austropotamobius pallipes and A. torrentium took place in the Late Oligocene, while the formation of the phyletic lineages and the dispersal from the Dinarides to Serbia occurred in the late Miocene and is probably associated with the complex and protracted process of disintegration of the Neogene freshwater lakes in southeastern Europe.
Benefits and risks of orthokeratology treatment: a systematic review and meta-analysis
Authors: Sartor Lauren , Hunter Damien S. , Vo Mai Linh , Samarawickrama Chameen 
Published: June 2024

Abstract
Background
This meta-analysis reviews the evidence for the risks and benefits associated with orthokeratology (OK) treatment compared with other methods of myopia control in children and adults.

Methods
A systematic search of Cochrane Central Register of Controlled Trials, Pubmed, Embase and Ovid was conducted from database inception to 22nd August 2021. Studies that reported on risks, visual and ocular biometric effects of OK in patients > 5 years of age with myopia (− 0.75 to − 6.00D) were included. Main outcomes are change in axial length and any adverse event.

Results
Fourty-five papers were included in this systematic review and meta-analysis. The quality of data was variable and of moderate certainty, and selection bias likely skewed the results towards a relative benefit for OK. The rate of axial elongation in children was lower for OK treatment compared to other treatment modalities at one year (MD − 0.16 mm, 95% CI − 0.25 to − 0.07). Rate of change in axial length in children rebounded after OK discontinuation compared to participants who continued treatment (MD 0.10 mm, 95% CI 0.06 to 0.14). Adults and children wearing OK were up to 3.79 times more likely to experience an adverse event when compared with conventional contact lenses (OR 3.79, 95% CI 1.24 to ll.), though this evidence base is underdeveloped and requires additional well-designed studies for substantial conclusions to be drawn.

Conclusions
OK arrests myopia progression while in use, however, there remain unanswered questions about the optimal duration of treatment, discontinuation effects and long-term risk for adverse events.
New Methods for Old Questions: The Use of Elliptic Fourier Analysis for the Formal Study of Palaeolithic Art
Authors: García-Bustos Miguel , García Bustos Paula , Rivero Olivia 
Published: June 2024

AbstractOne of the main objectives of Palaeolithic art researchers is to study and systematise the form of artistic representations. Some methodologies include the analysis of qualitative variables, linear measurements or the use of geometric morphometry with landmarks. However, these techniques depend to a large extent on the subjectivity of the researcher, which often leads to biased results. To overcome this issue, we present an application of geometric morphometry using Elliptic Fourier Analysis (EFA), together with multivariate statistics and hypothesis testing, for the first time to the study of form in prehistoric art. In order to explain its use, the “duck-bill” convention of pre-Magdalenian horses, often used as a chronological and geographical marker, has been used as a case study. This formalism is described disparately in the literature, so the main objective is to use EFA to determine whether it is possible to characterise this type of convention according to the definitions given by certain authors. The results indicate a possible classification of the heads of these animals. Through this taxonomic proposal, it has been possible to verify the great diversity of forms in which the authors classify the duck-bill horses and, therefore, to demonstrate that this peculiar form can be considered neither a conventionalism nor a chronological/regional marker. In conclusion, the methodology based on EFA combined with multivariate statistics for the objective study of form in prehistoric art is effective and opens a new avenue of analysis in the art of prehistoric societies.
Test of Specificity in Signalling between Potato Plants in Response to Infection by Fusarium Solani and Phytophthora Infestans
Authors: Martín-Cacheda Lucía , Röder Gregory , Abdala-Roberts Luis , Moreira Xoaquín 
Published: June 2024

AbstractPlant-plant signalling via volatile organic compounds (VOCs) in response to insect herbivory has been widely studied, but its occurrence and specificity in response to pathogen attack has received much less attention. To fill this gap, we carried out a greenhouse experiment using two fungal pathogens (Fusarium solani and Phytophthora infestans) to test for specificity in VOC induction and signalling between potato plants (Solanum tuberosum). We paired potato plants in plastic cages, one acting as VOC emitter and the other as receiver, and subjected emitters to one of the following treatments: no infection (control), infected by F. solani, or infected by P. infestans. We measured total emission and composition of VOCs released by emitter plants to test for pathogen-specificity in VOC induction, and then conducted a pathogen infection bioassay to assess resistance levels on receiver plants by subjecting half of the receivers of each emitter treatment to F. solani infection and the other half to P. infestans infection. This allowed us to test for specificity in plant VOC signalling by comparing its effects on conspecific and heterospecific sequential infections. Results showed that infection by neither F. solani or P. infestans produced quantitative (total emissions) or qualitative (compositional) changes in VOC emissions. Mirroring these patterns, emitter infection treatment (control vs. pathogen infection) did not produce a significant change in pathogen infection levels on receiver plants in any case (i.e., either for conspecific or heterospecific sequential infections), indicating a lack of signalling effects which precluded pathogen-based specificity in signalling. We discuss possible mechanisms for lack of pathogen effects on VOC emissions and call for future work testing for pathogen specificity in plant-plant signalling and its implications for plant-pathogen interactions under ecologically relevant scenarios involving infections by multiple pathogens.
Geometry of entanglement and separability in Hilbert subspaces of dimension up to three
Authors: Liss Rotem , Mor Tal , Winter Andreas 
Published: June 2024

AbstractWe present a complete classification of the geometry of the mutually complementary sets of entangled and separable states in three-dimensional Hilbert subspaces of bipartite and multipartite quantum systems. Our analysis begins by finding the geometric structure of the pure product states in a given three-dimensional Hilbert subspace, which determines all the possible separable and entangled mixed states over the same subspace. In bipartite systems, we characterise the 14 possible qualitatively different geometric shapes for the set of separable states in any three-dimensional Hilbert subspace (5 classes which also appear in two-dimensional subspaces and were found and analysed by Boyer et al. (Phys Rev A 95:032308, 2017. https://doi.org/10.1103/PhysRevA.95.032308), and 9 novel classes which appear only in three-dimensional subspaces), describe their geometries, and provide figures illustrating them. We also generalise these results to characterise the sets of fully separable states (and hence the complementary sets of somewhat entangled states) in three-dimensional subspaces of multipartite systems. Our results show which geometrical forms quantum entanglement can and cannot take in low-dimensional subspaces.