bluuebunny/crossref_metadata_2025_split huggingface dataset:
Linking digital transformational leadership, symmetrical internal communication with innovation capability: a moderated mediation model
Authors: Majumdarr Shubh , Dasgupta Shilpee A. , Hassan Yusuf , Behl Abhishek , Pereira Vijay 
Published: May 2024

Purpose
The purpose of this study is to investigate the relationship between digital transformational leadership (DTL) and innovation capability (IIC) in multinational (MNC) firms’ settings. The current study emphasises the mediating-moderating impact of symmetrical internal communication (SIC) and trust in leadership (TIL) in further shaping this relationship.

Design/methodology/approach
The researchers adopted three-wave data consisting of responses from 323 cross-border team members working in MNC firms. A moderated-mediation model was tested using Hynes’ Process Macro and IBM Amos.

Findings
The empirical findings underscore a positive relationship between DTL and IIC and the mediation by SIC. Furthermore, the researchers also identified a moderated mediation relationship of TIL.

Originality/value
To the best of the authors’ knowledge, this is the first study to investigate the moderated mediation relationship among DTL, SIC, IIC and TIL using the complexity leadership theory perspective.
Switzerland: Political Developments and Data in 2023
Authors: FREIBURGHAUS RAHEL 
Published: May 2024

AbstractIn 2023, Switzerland's profound integration into the globalized world was particularly evident, fundamentally challenging the notion of political sovereignty. Yet, this interconnectedness also means that Swiss domestic rules strongly reverberate around the world, such as in the case of policy failure regarding financial regulation. This article explores how global developments shape Swiss politics, from campaign dynamics ahead of the 2023 federal elections to externally imposed legislative agendas. Even the notorious “Swiss” direct democracy no longer solely reflects citizen‐initiated proposals as further evidenced that year. The article also underscores the inertia of Swiss‐style consensus democracy in gearing up its institutional design for polycrisis. It concludes with a discussion of two major political issues: the collapse of Credit Suisse, one of Switzerland's two leading banks, which marks the most far‐reaching shake‐up of the global banking sector since the 2008 financial crisis, and a potential break‐through in the longstanding stalemate in Swiss–EU relations.
Cytokine adsorption in patients with acute‐on‐chronic liver failure (CYTOHEP): A single center, open‐label, three‐arm, randomized, controlled intervention pilot trial
Authors: Sekandarzad Asieb , Graf Erika , Prager Eric Peter , Luxenburger Hendrik , Staudacher Dawid L. , Wengenmayer Tobias , Bettinger Dominik , Supady Alexander 
Published: May 2024

AbstractBackgroundTo investigate the efficacy of bilirubin reduction by hemoadsorption with CytoSorb® in patients with acute‐on‐chronic liver failure (ACLF) receiving continuous renal replacement therapy (CRRT).MethodsA prospective, randomized, single‐center, open‐label, controlled pilot trial. Patients with ACLF, acute kidney injury, and serum bilirubin ≥5 mg/dL were assigned 1:1:1 to one of three study groups (CRRT with or without hemoadsorption, no CRRT). In the hemoadsorption group, the CytoSorb adsorber was incorporated into the CRRT system, replaced after 12, 24, and 48 h, and removed after 72 h. The primary endpoint was the serum bilirubin level after 72 h.ResultsCYTOHEP was terminated early due to difficulties in recruiting patients and ethical concerns. Three of 9 patients (33%) were treated in each group. Comparing the three groups, mean bilirubin levels after 72 h were lower by −8.0 mg/dL in the “CRRT with hemoadsorption” group compared to “CRRT without hemoadsorption” (95% CI, −21.3 to 5.3 mg/dL; p = 0.17). The corresponding mean difference between “CRRT without hemoadsorption” and “no CRRT” was −1.4 mg/dL (95% CI, −14.2 to 11.5 mg/dL; p = 0.78). Comparing “CRRT with hemoadsorption” and “no CRRT,” it was −9.4 mg/dL (95% CI, −20.8 to 2.1 mg/dL; p = 0.0854). Only 1/9 patients (11%, “no CRRT” group) survived day 30 after study inclusion but died on day 89. IL‐6, liver function parameters, and clinical scores were similar between the study groups.ConclusionsCYTOHEP failed to demonstrate that extracorporeal hemoadsorption combined with CRRT can reduce serum bilirubin in ACLF patients with acute kidney failure.
Acetazolamide‐induced pulmonary oedema: A disproportionality analysis from the EudraVigilance database
Authors: García Montserrat , Albizua Madariaga Itziar , Sainz‐Gil María , Lertxundi Unax 
Published: May 2024

AbstractTo our knowledge, no prior study has analysed a possible association between acetazolamide and pulmonary oedema. The aim of this study was to use data from the EudraVigilance to detect a safety signal for acetazolamide‐induced pulmonary oedema. We performed a disproportionality analysis (case–noncase method), calculating reporting odds ratios (RORs) up to 22 February 2024. Among 11 684 208 spontaneous cases of adverse reactions registered in EudraVigilance, 38 275 were pulmonary oedemas. Acetazolamide was involved in 31 cases. In more than half of those cases, the patients received a single dose of acetazolamide after undergoing cataract surgery: latency was 10–90 min. Remarkably, there were five cases of positive rechallenge and six cases resulted in death. The ROR for acetazolamide was 3.63 (95% CI 2.55–5.17). Disproportionality was also observed in VigiBase®: ROR 4.44 (95% CI 3.34–5.90). Our study confirms a signal that suggests a risk of serious pulmonary oedema associated with acetazolamide.
Symmetrical drug‐related intertriginous and flexural exanthema (SDRIFE) after administration of corticosteroids: Case series and review of literature
Authors: Steininger Julian , Bauer Andrea , Hasler Helena , Beissert Stefan , Abraham Susanne 
Published: May 2024

AbstractBackgroundCutaneous manifestations of drug‐induced type IV reactions vary widely, with symmetrical drug‐related intertriginous and flexural exanthema (SDRIFE) being a less common presentation. Corticosteroids (CS), primarily known for their anti‐inflammatory effects, rarely induce hypersensitivity reactions.ObjectiveThe aim of this case series is to report four cases of SDRIFE following systemic prednisolone therapy and to review existing CS classification proposals to better understand cross‐reactivity of CS.Patients/MethodsPatients recruited at a German dermatology centre underwent allergologic evaluation including prick and patch testing with various CS. Positive cases underwent oral challenge testing with alternative agents. The classification systems of Coopman et al. and Baeck et al. were taken into account.DiscussionDespite a paucity of literature, CS‐induced type IV reactions do occur, including SDRIFE. Classification systems based on chemical structure provide insight into cross‐reactivity patterns. Provocation tests with alternative CS highlight the complexity of managing CS hypersensitivity.ConclusionSDRIFE may develop following systemic prednisolone therapy. Classification systems are helpful in understanding cross‐reactivity and help in the selection of alternative preparations but are not always reliable. Individualised assessment is crucial for managing CS hypersensitivity, with consideration of alternative agents and emergency use of CS when necessary.
Pioglitazone‐induced alterations of purine metabolism in healthy male subjects
Authors: Kang Jihyun , Li Yufei , Lee SeungHwan , Yu Kyung‐Sang , Cho Joo‐Youn 
Published: May 2024

AbstractPioglitazone is class of thiazolidinediones that activates peroxisome proliferator‐activated receptors (PPARs) in adipocytes to improve glucose metabolism and insulin sensitivity and has been used as a treatment for type 2 diabetes. However, the underlying mechanisms of associated pioglitazone‐induced effects remain unclear. Our study aimed to investigate endogenous metabolite alterations associated with pioglitazone administration in healthy male subjects using an untargeted metabolomics approach. All subjects received 30 mg of pioglitazone once daily in the assigned sequence and period. Urine samples were collected before pioglitazone administration and for 24 h after 7 days of administration. A total of 1465 compounds were detected and filtered using a coefficient of variance below 30% and 108 metabolites were significantly altered upon pioglitazone administration via multivariate statistical analysis. Fourteen significant metabolites were identified using authentic standards and public libraries. Additionally, pathway analysis revealed that metabolites from purine and beta‐alanine metabolisms were significantly altered after pioglitazone administration. Further analysis of quantification of metabolites from purine metabolism, revealed that the xanthine/hypoxanthine and uric acid/xanthine ratios were significantly decreased at post‐dose. Pioglitazone‐dependent endogenous metabolites and metabolic ratio indicated the potential effect of pioglitazone on the activation of PPAR and fatty acid synthesis. Additional studies involving patients are required to validate these findings.
Adding mechanobiological cell features to finite element analysis of an immediately loaded dental implant
Authors: Martinello Poliana Alexandra , Cartagena‐Molina Andrés Felipe , Capelletti Lucas Kravchychyn , Fernandes Bruno Viezzer , Franco Ana Paula Gebert de Oliveira , Mercuri Emilio Graciliano Ferreira , Bombarda Nara Hellen Campanha 
Published: May 2024

AbstractFinite element analysis (FEA) has been used to analyze the behavior of dental materials, mainly in implantology. However, FEA is a mechanical analysis and few studies have tried to simulate the biological characteristics of the healing process of loaded implants. This study used the rule of mixtures to simulate the biological healing process of immediate implants in an alveolus socket and bone‐implant junction interface through FEA. Three‐dimensional geometric models of the structures were obtained, and material properties were derived from the literature. The rule of mixtures was used to simulate the healing periods—immediate and early loading, in which the concentration of each cell type, based on in vivo studies, influenced the final elastic moduli. A 100 N occlusal load was simulated in axial and oblique directions. The models were evaluated for maximum and minimum principal strains, and the bone overload was assessed through Frost's mechanostat. There was a higher strain concentration in the healing regions and cortical bone tissue near the cervical portion. The bone overload was higher in the immediate load condition. The method used in this study may help to simulate the biological healing process and could be useful to relate FEA results to clinical practice.
Related barriers to using HIV pre‐exposure prophylaxis among MSM: A multicentre cross‐sectional survey
Authors: Yang Xue , Zhang Guang , Kang Wenting , Guo Jiahuan , Liu An , Tang Houlin , Liu Tongtong , Sun Lijun 
Published: May 2024

AbstractObjectiveThe objective of this study was to gain insight into the barriers hindering the use of pre‐exposure prophylaxis (PrEP) among men who have sex with men (MSM) in five cities in China.MethodsMSM were recruited via community‐based organizations in an online “snowball” manner. Participants completed the questionnaire anonymously and shared it with key MSM peers (seeds) in five cities in China. Based on the results of univariate analysis, we used a structural equation model to analyse the role of PrEP knowledge awareness, PrEP counselling, and other behavioural variables on PrEP use.ResultsThe study collected a total of 4223 valid questionnaires, and 18.2% of participants reported PrEP use. The results of the standardized total effects showed that the following paths were statistically significant (p < 0.05): from the age of first sex with men to PrEP knowledge awareness (β = −0.113) and PrEP use (β = 0.042); from high‐risk sexual behaviour scores to PrEP counselling (β = 0.039) and PrEP use (β = 0.103); from the number of HIV tests in the last year to PrEP knowledge awareness (β = 0.034), PrEP counselling (β = 0.170), and PrEP use (β = 0.197); from the level of self‐perceived risk of HIV infection to PrEP counselling (β = −0.115); from PrEP knowledge awareness to PrEP use (β = −0.049); and from PrEP counselling to PrEP use (β = 0.420).ConclusionsThe proportion of PrEP use among MSM was relatively low. Age at first sex with men, number of HIV tests, high‐risk sexual behaviour, and PrEP counselling had a positive effect on PrEP use, whereas PrEP knowledge awareness had an inverse effect on PrEP use.
Indirect Discrimination and the Hospital Relocation Cases
Authors: Hutler Brian 
Published: May 2024

ABSTRACTThis article develops a theory of indirect discrimination by analyzing a series of lawsuits that challenged hospital relocations in the 1970s. In these cases, civil rights groups argued that the relocation of hospitals from cities to suburbs was a form of racial discrimination. Although these lawsuits failed, I aim to support the plaintiffs' arguments that the hospital relocations were discriminatory. Drawing on three recent theories – those of Benjamin Eidelson, Deborah Hellman, and Sophia Moreau – I develop an account of indirect discrimination that is rooted in resource‐specific equality rights such as those found in international human rights law. Building on this account, I argue that the human right to health equity can explain why the hospital relocations were discriminatory.
Monitoring post‐spawning movement, habitat use, and survival of adult anadromous rainbow smelt using acoustic telemetry in a New Hampshire estuary
Authors: Pearson Chloe F. , Hammer Lars J. , Eberhardt Alyson L. , Kenter Linas W. , Berlinsky David L. , Costello Wellsley J. , Hermann Nathan T. , Caldwell Aliya , Burke Emily A. , Walther Benjamin D. , Furey Nathan B. 
Published: May 2024

AbstractAnadromous rainbow smelt (Osmerus mordax, [Mitchill 1814]) are found along the northeast Atlantic coastline of North America, with their range now limited to north of Cape Cod, Massachusetts, USA. Although their anadromous life cycles are described broadly, gaps remain regarding how adult rainbow smelt use estuaries post‐spawning, including movement behaviors, habitats used, and specific timing of emigration to coastal waters. In spring 2021, we used acoustic telemetry to characterize movements during and after the spawning season of rainbow smelt captured in tributaries to Great Bay, New Hampshire, USA, a large estuarine system near the southern edge of their range. Forty‐four adult rainbow smelt (n = 35 male, n = 9 female) were tagged with Innovasea V5 180‐kHz transmitters and an array of 22,180 kHz VR2W receivers were deployed throughout Great Bay to detect movements of tagged fish from March to October 2021. Rainbow smelt were detected 14,186 times on acoustic telemetry receivers, with 41 (93%) of the tagged individuals being detected at least once post‐tagging. Individuals were detected moving between tributaries, revealing that rainbow smelt can use multiple rivers during the spawning season (March–April). Mark‐recapture Cormack‐Jolly‐Seber models estimated 83% (95% confidence interval 66%–92%) of rainbow smelt survived to the mainstem Piscataqua River, and a minimum of 50% (22 of 44) reached the seaward‐most receivers and were presumed to have survived emigration. Most individuals that survived remained in the estuary for multiple weeks (average = 19.47 ± 1.99 standard error days), displaying extended use of estuarine environments. Downstream movements occurred more frequently during ebb tides and upstream movements with flood tides, possibly a mechanism to reduce energy expenditures. Fish emigrated from the estuary by mid‐May to the coastal Gulf of Maine. Our results underscore that rainbow smelt need access to a variety of habitats, including multiple tributaries and high‐quality estuarine habitat, to complete their life cycle.
Emerging innovative pre‐ and post‐harvest management practices to mitigate patulin‐linked food safety risks in apple and its products
Authors: Singh Sukhvinder Pal , Sharma Rakesh , Suthar Priyanka , Thakur Monika 
Published: May 2024

AbstractPatulin, a toxic secondary metabolite produced by certain molds (Penicillium, Aspergillus, and Byssochlamys), poses a significant health risk when present in apple juice products above permissible levels. Its presence is a major concern for both consumers and regulatory bodies due to its potential carcinogenic and mutagenic effects. Minimizing patulin concentration in apple juice products requires a multifaceted approach involving various stages of apple fruit production, from orchard management to processing and storage. This review explores the pre‐ and postharvest strategies associated with minimizing patulin concentration in apple juice products. It examines the role of good agricultural practices in reducing mold contamination in orchards and discusses the importance of proper postharvest handling, including fruit sorting and washing to remove contaminated apples before processing. During processing, factors such as temperature, pH, and processing time play crucial roles in minimizing patulin levels. Innovative processing technologies, such as pulsed electric fields (PEF), ultraviolet (UV) radiation, high‐pressure processing, enzymatic, and chemical degradation have shown promise in reducing patulin concentration while preserving the sensory and nutritional quality of the juice. Furthermore, effective storage practices, such as maintaining proper temperature and humidity levels, are essential for preventing patulin formation during storage. Continuous monitoring and analytical testing for patulin content throughout the production chain are necessary to ensure compliance with regulatory standards and to guarantee the safety of apple juice products. Despite advancements in technology and production practices, challenges remain in effectively minimizing patulin concentration. These include the need for further research to develop more efficient detection methods, the adoption of sustainable and eco‐friendly practices in orchard management, and the dissemination of knowledge and best practices to stakeholders across the apple juice supply chain. In conclusion, minimizing patulin concentration in apple juice products requires a holistic approach that integrates preventive measures, innovative processing technologies, and stringent quality control measures. By addressing these challenges, the apple juice industry can ensure the production of safe and high‐quality products that meet regulatory standards and consumer expectations.
Correlative analysis of different treatments of persistent occipitotransverse position on the outcome for mother and infant
Authors: Lin Chunxia , Zhou Jun , Mao Shengyan , Tang Jia , Qiu Guangyin , Zheng Zhaoping , Wang Litao , Lin Jie 
Published: May 2024

AbstractObjectiveTo explore the clinical feasibility of different treatment methods for persistent occipitotransverse position and the influence on maternal and infant complications.MethodDuring the trial of vaginal delivery from April 2020 to March 2023 in our hospital, the cervix was fully dilated and the presentation was located at +2 station. Ninety‐six pregnant women with fetal presentation at +4 station, occipitotransverse fetal position, maternal complications, abnormalities in the second stage of labor, and or fetal distress were divided into two groups: 65 patients with Kielland forceps vaginal delivery and 31 patients underwent emergency cesarean section. The delivery time, vaginal laceration rate, postpartum blood loss volume, puerperal infection rate, neonatal birth injury rate, and neonatal 1 min Apgar scores were analyzed.ResultsThe delivery outcomes and maternal and neonatal complications of 96 pregnant women were analyzed: the application of Kielland forceps delivery time was shorter, while the vaginal laceration rate, postpartum hemorrhage, puerperal infection rate were significantly lower than that of patients undergoing emergency cesarean section and the neonatal 1 min Apgar score was higher than that of emergency cesarean section group (p < 0.05).ConclusionIt was clinically appropriate to use Kielland forceps in vaginal delivery when the persistent occipitotransverse position was present and delivery needed to be expediated. Use of Kielland forceps can shorten the delivery time, improve the success rate of vaginal delivery and reduce the complications of mothers and infants.
OsMPK12 positively regulates rice blast resistance via OsEDC4‐mediated transcriptional regulation of immune‐related genes
Authors: Lu Ling , Zhang Jing , Zheng Xingxing , Xia Na , Diao Zhijuan , Wang Xun , Chen Zhiwei , Tang Dingzhong , Li Shengping 
Published: May 2024

AbstractMitogen‐activated protein kinase (MAPK) signalling cascades are functionally important signalling modules in eukaryotes. Transcriptome reprogramming of immune‐related genes is a key process in plant immunity. Emerging evidence shows that plant MAPK cascade is associated with processing (P)‐body components and contributes to transcriptome reprogramming of immune‐related genes. However, it remains largely unknown how this process is regulated. Here, we show that OsMPK12, which is induced by Magnaporthe oryzae infection, positively regulates rice blast resistance. Further analysis revealed that OsMPK12 directly interacts with enhancer of mRNA decapping protein 4 (OsEDC4), a P‐body‐located protein, and recruits OsEDC4 to where OsMPK12 is enriched. Importantly, OsEDC4 directly interacts with two decapping complex members OsDCP1 and OsDCP2, indicating that OsEDC4 is a subunit of the mRNA decapping complex. Additionally, we found that OsEDC4 positively regulates rice blast resistance by regulating expression of immune‐related genes and maintaining proper mRNA levels of some negatively‐regulated genes. And OsMPK12 and OsEDC4 are also involved in rice growth and development regulation. Taken together, our data demonstrate that OsMPK12 positively regulates rice blast resistance via OsEDC4‐mediated mRNA decay of immune‐related genes, providing new insight into not only the new role of the MAPK signalling cascade, but also posttranscriptional regulation of immune‐related genes.