bluuebunny/crossref_metadata_2025_split huggingface dataset:
Decompressive Surgery in Cerebrovenous Thrombosis
Authors: Ferro José M. , Crassard Isabelle , Coutinho Jonathan M. , Canhão Patrícia , Barinagarrementeria Fernando , Cucchiara Brett , Derex Laurent , Lichy Christoph , Masjuan Jaime , Massaro Ayrton , Matamala Gonzalo , Poli Sven , Saadatnia Mohammad , Stolz Erwin , Viana-Baptista Miguel , Stam Jan , Bousser Marie-Germaine ,   Second International Study on Cerebral Vein and Dural Sinus Thrombosis (ISCVT 2) Investigators
Published: July 2011

Background and Purpose—
Herniation attributable to unilateral mass effect is the major cause of death in cerebral venous thrombosis (CVT). Decompressive surgery may be lifesaving in these patients.

Methods—
Retrospective registry of cases of acute CVT treated with decompressive surgery (craniectomy or hematoma evacuation) in 22 centers and systematic review of all published cases of CVT treated with decompressive surgery. The primary outcome was the score on the modified Rankin Scale (mRS) score at last follow-up, dichotomized between favorable (mRS score, 0–4) and unfavorable outcome (mRS score, 5 or death). Secondary outcomes were complete recovery (mRS score 0–1), independence (mRS score, 0–2), severe dependence (mRS score, 4–5), and death at last available follow-up.

Results—

Sixty-nine patients were included and 38 were from the registry. Decompressive craniectomy was performed in 45 patients, hematoma evacuation was performed in 7, and both interventions were performed in 17 patients. At last follow-up (median, 12 months) only 12 (17.4%) had un unfavorable outcome. Twenty-six (37.7%) had mRS score 0 to 1, 39 (56.5%) had mRS score 0 to 2, 4 (5.8%) were alive with mRS score 4 to 5, and 11 (15.9%) patients died. Three of the 9 patients with bilateral fixed pupils recovered completely. Comatose patients were less likely to be independent (mRS score 0–2) than noncomatose patients (45% versus 84%;
P
=0.003). Patients with bilateral lesions were more likely to have unfavorable outcomes (50% versus 11%;
P
=0.004) and to die (42% versus 11%;
P
=0.025).

Conclusions—
In CVT patients with large parenchymal lesions causing herniation, decompressive surgery was lifesaving and often resulted in good functional outcome, even in patients with severe clinical conditions.
Safety and Functional Outcome of Thrombolysis in Dissection-Related Ischemic Stroke
Authors: Zinkstok Sanne M. , Vergouwen Mervyn D.I. , Engelter Stefan T. , Lyrer Philippe A. , Bonati Leo H. , Arnold Marcel , Mattle Heinrich P. , Fischer Urs , Sarikaya Hakan , Baumgartner Ralf W. , Georgiadis Dimitrios , Odier Céline , Michel Patrik , Putaala Jukka , Griebe Martin , Wahlgren Nils , Ahmed Niaz , van Geloven Nan , de Haan Rob J. , Nederkoorn Paul J. 
Published: July 2011

Background and Purpose—
The safety and efficacy of thrombolysis in cervical artery dissection (CAD) are controversial. The aim of this meta-analysis was to pool all individual patient data and provide a valid estimate of safety and outcome of thrombolysis in CAD.

Methods—
We performed a systematic literature search on intravenous and intra-arterial thrombolysis in CAD. We calculated the rates of pooled symptomatic intracranial hemorrhage and mortality and indirectly compared them with matched controls from the Safe Implementation of Thrombolysis in Stroke–International Stroke Thrombolysis Register. We applied multivariate regression models to identify predictors of excellent (modified Rankin Scale=0 to 1) and favorable (modified Rankin Scale=0 to 2) outcome.

Results—
We obtained individual patient data of 180 patients from 14 retrospective series and 22 case reports. Patients were predominantly female (68%), with a mean±SD age of 46±11 years. Most patients presented with severe stroke (median National Institutes of Health Stroke Scale score=16). Treatment was intravenous thrombolysis in 67% and intra-arterial thrombolysis in 33%. Median follow-up was 3 months. The pooled symptomatic intracranial hemorrhage rate was 3.1% (95% CI, 1.3 to 7.2). Overall mortality was 8.1% (95% CI, 4.9 to 13.2), and 41.0% (95% CI, 31.4 to 51.4) had an excellent outcome. Stroke severity was a strong predictor of outcome. Overlapping confidence intervals of end points indicated no relevant differences with matched controls from the Safe Implementation of Thrombolysis in Stroke–International Stroke Thrombolysis Register.

Conclusions—
Safety and outcome of thrombolysis in patients with CAD-related stroke appear similar to those for stroke from all causes. Based on our findings, thrombolysis should not be withheld in patients with CAD.
Dietary Potassium Intake and Risk of Stroke
Authors: Larsson Susanna C. , Orsini Nicola , Wolk Alicja 
Published: July 2011

Background and Purpose—
Potassium intake has been inconsistently associated with risk of stroke. Our aim was to conduct a meta-analysis of prospective studies to assess the relation between potassium intake and stroke risk.

Methods—
Pertinent studies were identified by a search of PubMed from January 1966 through March 2011 and by reviewing the reference lists of retrieved articles. We included prospective studies that reported relative risks with 95% CIs of stroke for ≥3 categories of potassium intake or for potassium intake analyzed as a continuous variable. Study-specific results were pooled using a random-effects model.

Results—
Ten independent prospective studies, with a total of 8695 stroke cases and 268 276 participants, were included in the meta-analysis. We observed a statistically significant inverse association between potassium intake and risk of stroke. For every 1000-mg/day increase in potassium intake, the risk of stroke decreased by 11% (pooled relative risk, 0.89; 95% CI, 0.83 to 0.97). In the 5 studies that reported results for stroke subtypes, the pooled relative risks were 0.89 (95% CI, 0.81 to 0.97) for ischemic stroke, 0.95 (95% CI, 0.83 to 1.09) for intracerebral hemorrhage, and 1.08 (95% CI, 0.92 to 1.27) for subarachnoid hemorrhage.

Conclusions—
Dietary potassium intake is inversely associated with risk of stroke, in particular ischemic stroke.
Local time policies in Europe
Authors: Mückenberger Ulrich 
Published: July 2011

Urban temporal policies – policies intended to coordinate working times, public and private service times, and the urban time schedules to the needs of human beings, individuals, families, communities – seem to gain ground across Europe. They stem from new time compression experiences in everyday working, leisure and family life of citizens, but particularly among women. They focus on different local policy areas – like transport, school, child- and elderly-care, security, services, urban planning, work-life balance, etc. – and tend to restructure these areas in a humane, time-aware mode. Local time policies are necessarily participative policies including stakeholders as the subjects of change. Since the early 1990s this new type of policy has spread over West Europe – starting from Italy (‘tempi della città’) and extending to Germany, France, Spain, Ireland, and Finland. Now, time policies are becoming more influential in central and eastern Europe as well. Recently, on 28 October 2010, the Congress of Local and Regional Authorities of the Council of Europe adopted a recommendation (Rec 295(2010)) and a resolution (Res 313 (2010)) addressed to its 47 member states favouring local time policies. In 2009, the Congress’s Committee for Social Cohesion had taken up the issue. The political reporter, Clotilde Tascon-Mennetrier, and the scientific commentator, Professor Ulrich Mückenberger, submitted a proposal of recommendations to the Committee. After two extensive deliberations, supported by both reporter and commentator, the Committee unanimously adopted these recommendations on 16 March 2010 (CPL/SOC(17)2). In October 2010, after a slight redraft, the docu-ment was passed by the Congress implementing large parts of the opinion of Professor Mückenberger. Now it is up to the Committee of Ministers to deliberate the resolution and to take measures accordingly. In the following, two texts from this process are documented. When taking up the subject of local time policies, the Committee of Social Cohesion asked Professor Mückenberger to be the general commentator for Europe and to submit a general report with policy recommendations for the Council of Europe.1 The following article basically corresponds to this report; the policy recommendations are left aside because they have been mainly integrated into both the Congress of Local and Regional Authorities’ recommendation 295(2010) (see Appendix 1 below) and the Congress resolution 313 (2010) (see Appendix 2 below).
Perceived Family Resources Based on Number of Members With ADHD
Authors: Corwin Melinda , Mulsow Miriam , Feng Du 
Published: July 2011

Objective: This study examines how the number of family members with ADHD affects other family members’ perceived resources. Method: A total of 40 adolescents diagnosed with ADHD and their mothers, fathers, and adolescent siblings living in the household participated. Hierarchical linear modeling was used to analyze family-level data from a total of 130 participants. Results: Mothers reported more resources when only the target adolescent had ADHD and more nonsupportive factors when more than one member of the family had ADHD. Fathers reported more supportive factors when only one member of the family had ADHD. Conclusion: Parents reported greater resources and strengths when only one adolescent family member had ADHD; however, family members had varying viewpoints. The ADHD Family Scale examined issues specific to ADHD, compared with general family stress and resource scales, and may be a useful tool for examining the impact of ADHD on all members of a family.
Hemodynamic and clinical onset in patients with hereditary pulmonary arterial hypertension and BMPR2 mutations
Authors: Pfarr Nicole , Szamalek-Hoegel Justyna , Fischer Christine , Hinderhofer Katrin , Nagel Christian , Ehlken Nicola , Tiede Henning , Olschewski Horst , Reichenberger Frank , Ghofrani Ardeschir HA , Seeger Werner , Grünig Ekkehard 
Published: July 2011

Abstract

Background
Mutations in the bone morphogenetic protein receptor 2 (BMPR2) gene can lead to idiopathic pulmonary arterial hypertension (IPAH). This study prospectively screened for BMPR2 mutations in a large cohort of PAH-patients and compared clinical features between BMPR2 mutation carriers and non-carriers.

Methods
Patients have been assessed by right heart catheterization and genetic testing. In all patients a detailed family history and pedigree analysis have been obtained. We compared age at diagnosis and hemodynamic parameters between carriers and non-carriers of BMPR2 mutations. In non-carriers with familial aggregation of PAH further genes/gene regions as the BMPR2 promoter region, the ACVRL1, Endoglin, and SMAD8 genes have been analysed.

Results
Of the 231 index patients 22 revealed a confirmed familial aggregation of the disease (HPAH), 209 patients had sporadic IPAH. In 49 patients (86.3% of patients with familial aggregation and 14.3% of sporadic IPAH) mutations of the BMPR2 gene have been identified. Twelve BMPR2 mutations and 3 unclassified sequence variants have not yet been described before. Mutation carriers were significantly younger at diagnosis than non-carriers (38.53 ± 12.38 vs. 45.78 ± 11.32 years, p < 0.001) and had a more severe hemodynamic compromise. No gene defects have been detected in 3 patients with HPAH.

Conclusion
This study identified in a large prospectively assessed cohort of PAH- patients new BMPR2 mutations, which have not been described before and confirmed previous findings that mutation carriers are younger at diagnosis with a more severe hemodynamic compromise. Thus, screening for BMPR2 mutations may be clinically useful.
Application of an efficient Bayesian discretization method to biomedical data
Authors: Lustgarten Jonathan L , Visweswaran Shyam , Gopalakrishnan Vanathi , Cooper Gregory F 
Published: July 2011

Abstract

Background
Several data mining methods require data that are discrete, and other methods often perform better with discrete data. We introduce an efficient Bayesian discretization (EBD) method for optimal discretization of variables that runs efficiently on high-dimensional biomedical datasets. The EBD method consists of two components, namely, a Bayesian score to evaluate discretizations and a dynamic programming search procedure to efficiently search the space of possible discretizations. We compared the performance of EBD to Fayyad and Irani's (FI) discretization method, which is commonly used for discretization.

Results
On 24 biomedical datasets obtained from high-throughput transcriptomic and proteomic studies, the classification performances of the C4.5 classifier and the naïve Bayes classifier were statistically significantly better when the predictor variables were discretized using EBD over FI. EBD was statistically significantly more stable to the variability of the datasets than FI. However, EBD was less robust, though not statistically significantly so, than FI and produced slightly more complex discretizations than FI.

Conclusions
On a range of biomedical datasets, a Bayesian discretization method (EBD) yielded better classification performance and stability but was less robust than the widely used FI discretization method. The EBD discretization method is easy to implement, permits the incorporation of prior knowledge and belief, and is sufficiently fast for application to high-dimensional data.
Rigorous assessment and integration of the sequence and structure based features to predict hot spots
Authors: Chen Ruoying , Chen Wenjing , Yang Sixiao , Wu Di , Wang Yong , Tian Yingjie , Shi Yong 
Published: July 2011

AbstractBackgroundSystematic mutagenesis studies have shown that only a few interface residues termed hot spots contribute significantly to the binding free energy of protein-protein interactions. Therefore, hot spots prediction becomes increasingly important for well understanding the essence of proteins interactions and helping narrow down the search space for drug design. Currently many computational methods have been developed by proposing different features. However comparative assessment of these features and furthermore effective and accurate methods are still in pressing need.ResultsIn this study, we first comprehensively collect the features to discriminate hot spots and non-hot spots and analyze their distributions. We find that hot spots have lower relASA and larger relative change in ASA, suggesting hot spots tend to be protected from bulk solvent. In addition, hot spots have more contacts including hydrogen bonds, salt bridges, and atomic contacts, which favor complexes formation. Interestingly, we find that conservation score and sequence entropy are not significantly different between hot spots and non-hot spots in Ab+ dataset (all complexes). While in Ab- dataset (antigen-antibody complexes are excluded), there are significant differences in two features between hot pots and non-hot spots. Secondly, we explore the predictive ability for each feature and the combinations of features by support vector machines (SVMs). The results indicate that sequence-based feature outperforms other combinations of features with reasonable accuracy, with a precision of 0.69, a recall of 0.68, an F1 score of 0.68, and an AUC of 0.68 on independent test set. Compared with other machine learning methods and two energy-based approaches, our approach achieves the best performance. Moreover, we demonstrate the applicability of our method to predict hot spots of two protein complexes.ConclusionExperimental results show that support vector machine classifiers are quite effective in predicting hot spots based on sequence features. Hot spots cannot be fully predicted through simple analysis based on physicochemical characteristics, but there is reason to believe that integration of features and machine learning methods can remarkably improve the predictive performance for hot spots.
Genome evolution in the fish family salmonidae: generation of a brook charr genetic map and comparisons among charrs (Arctic charr and brook charr) with rainbow trout
Authors: Timusk Evan R , Ferguson Moira M , Moghadam Hooman K , Norman Joseph D , Wilson Chris C , Danzmann Roy G 
Published: July 2011

Abstract

Background
Salmonids are regarded as 4R derivative species, having experienced 4 whole genome duplication events in their ancestry. Many duplicated chromosome regions still share extensive homology with one another which is maintained primarily through male-based homeologous chromosome pairings during meiosis. The formation of quadrivalents during meiosis leads to pseudolinkage. This phenomenon is more prevalent within 5 of the 12 ancestral teleost linkage groups in salmonids.

Results
We constructed a genetic linkage map for brook charr and used this in combination with the genetic map from Arctic charr, to make comparisons with the genetic map of rainbow trout. Although not all chromosome arms are currently mapped, some homologous chromosome rearrangements were evident between Arctic charr and brook charr. Notably, 10 chromosome arms in brook charr representing 5 metacentric chromosomes in Arctic charr have undergone rearrangements. Three metacentrics have one arm translocated and fused with another chromosome arm in brook charr to a make a new metacentrics while two metacentrics are represented by 4 acrocentric pairs in brook charr. In two cases (i.e., BC-4 and BC-16), an apparent polymorphism was observed with the identification of both a putative metacentric structure (similar to metacentric AC-4 = BC-4 and a joining of acrocentric AC-16 + one arm of AC-28 = BC-16), as well as two separate acrocentric linkage groups evident in the mapping parents. Forty-six of the expected 50 karyotypic arms could be inter-generically assigned. SEX in brook charr (BC-4) was localized to the same homologous linkage group region as in Arctic charr (AC-4). The homeologous affinities detected in the two charr species facilitated the identification of 20 (expected number = 25) shared syntenic regions with rainbow trout, although it is likely that some of these regions were partial or overlapping arm regions.

Conclusions
Inter-generic comparisons among 2 species of charr (genus Salvelinus) and a trout (genus Oncorhynchus) have identified that linkage group arm arrangements are largely retained among these species. Previous studies have revealed that up to 7 regions of high duplicate marker retention occur between Salmo species (i.e., Atlantic salmon and brown trout) and rainbow trout, with 5 of these regions exhibiting higher levels of pseudolinkage. Pseudolinkage was detected in the charr species (i.e., BC-1/21, AC-12/27, AC-6/23, = RT-2p/29q, RT-12p/16p, and RT-27p/31p, respectively) consistent with three of the five 'salmonid-specific' pseudolinkage regions. Chromosome arms with the highest number of duplicated markers in rainbow trout are the linkage group arms with the highest retention of duplicated markers in both charr species.
Addressing challenges in the production and analysis of illumina sequencing data
Authors: Kircher Martin , Heyn Patricia , Kelso Janet 
Published: July 2011

Abstract
Advances in DNA sequencing technologies have made it possible to generate large amounts of sequence data very rapidly and at substantially lower cost than capillary sequencing. These new technologies have specific characteristics and limitations that require either consideration during project design, or which must be addressed during data analysis. Specialist skills, both at the laboratory and the computational stages of project design and analysis, are crucial to the generation of high quality data from these new platforms. The Illumina sequencers (including the Genome Analyzers I/II/IIe/IIx and the new HiScan and HiSeq) represent a widely used platform providing parallel readout of several hundred million immobilized sequences using fluorescent-dye reversible-terminator chemistry. Sequencing library quality, sample handling, instrument settings and sequencing chemistry have a strong impact on sequencing run quality. The presence of adapter chimeras and adapter sequences at the end of short-insert molecules, as well as increased error rates and short read lengths complicate many computational analyses. We discuss here some of the factors that influence the frequency and severity of these problems and provide solutions for circumventing these. Further, we present a set of general principles for good analysis practice that enable problems with sequencing runs to be identified and dealt with.
Patterns, trends and sex differences in HIV/AIDS reported mortality in Latin American countries: 1996-2007
Authors: Alonso Gonzalez Monica , Martin Luise , Munoz Sergio , Jacobson Jerry O 
Published: July 2011

Abstract

Background
International cohort studies have shown that antiretroviral treatment (ART) has improved survival of HIV-infected individuals. National population based studies of HIV mortality exist in industrialized settings but few have been presented from developing countries. Our objective was to investigate on a population basis, the regional situation regarding HIV mortality and trends in Latin America (LA) in the context of adoption of public ART policies and gender differences.

Methods
Cause of death data from vital statistics registries from 1996 to 2007 with "good" or "average" quality of mortality data were examined. Standardized mortality rates and Poisson regression models by country were developed and differences among countries assessed to identify patterns of HIV mortality over time occurring in Latin America.

Results
Standardized HIV mortality following the adoption of public ART policies was highest in Panama and El Salvador and lowest in Chile. During the study period, three overall patterns were identified in HIV mortality trends- following the adoption of the free ART public policies; a remarkable decrement, a remarkable increment and a slight increment. HIV mortality was consistently higher in males compared to females. Mean age of death attributable to HIV increased in the majority of countries over the study period.

Conclusions
Vital statistics registries provide valuable information on HIV mortality in LA. While the introduction of national policies for free ART provision has coincided with declines in population-level HIV mortality and increasing age of death in some countries, in others HIV mortality has increased. Barriers to effective ART implementation and uptake in the context of free ART public provision policies should be further investigated.