bluuebunny/crossref_metadata_2025_split huggingface dataset:
Peritoneal washing cytologic analysis of ovarian serous tumors of low malignant potential to detect peritoneal implants and predict clinical outcome
Authors: Sneige Nour , Thomison John B. , Malpica Anais , Gong Yun , Ensor Joe , Silva Elvio G. 
Published: July 2012

AbstractBACKGROUND:Patients with ovarian serous tumors of low malignant potential (OSLMP) who have peritoneal implants, especially invasive implants, are at an increased risk of developing tumor recurrence. To the best of the authors' knowledge, the ability of peritoneal washing (PW) cytology to detect the presence and type of peritoneal implants has not been adequately investigated, and its prognostic significance is unknown.METHODS:Records and PW specimens of 101 patients diagnosed with and treated for OSLMP between 1996 and 2010 at The University of Texas MD Anderson Cancer Center were retrospectively reviewed. Patients' staging biopsy findings were compared with the results of the authors' review of the PWs. Follow‐up data were also analyzed.RESULTS:Of the 96 patients for whom staging biopsy results were available, 26 (27%) had peritoneal implants (17 noninvasive and 9 invasive), 19 (20%) had endosalpingiosis, and 51 (53%) had negative findings. The PW specimens of 18 of the 26 patients (69%) with peritoneal implants were positive for serous neoplasm, and a correlation was found between cytologic and histologic findings (P < .0001). The sensitivity, specificity, positive predictive value, and negative predictive value were 69%, 84%, 62%, and 88%, respectively. Four of 101 patients had disease recurrence; 3 of these patients had invasive implants and 1 patient had noninvasive implants. None of the patients who had negative staging biopsy findings or endosalpingiosis but did have PW specimens that were positive for serous neoplasm developed disease recurrence.CONCLUSIONS:PW cytology detects the presence of peritoneal implants with moderate accuracy. However, long‐term studies are needed to determine whether positive PW cytologic findings are an independent predictor of tumor recurrence. Cancer (Cancer Cytopathol) 2012;. © 2012 American Cancer Society.
Selective expression of α‐synuclein‐immunoreactivity in vesicular acetylcholine transporter‐immunoreactive axons in the guinea pig rectum and human colon
Authors: Sharrad Dale F. , de Vries Elsbeth , Brookes Simon J.H. 
Published: July 2012

AbstractParkinson's disease is a neurodegenerative disorder characterized by motor and nonmotor impairments, including constipation. The hallmark pathological features of Parkinson's disease are Lewy bodies and neurites, of which aggregated α‐synuclein is a major constituent. Frequently, Lewy pathology is identified in the distal gut of constipated Parkinson's disease patients. The neurons that innervate the distal gut that express α‐synuclein have not been identified. We used multiple‐labeling immunohistochemistry and anterograde tracing to quantify which neurons projecting to the guinea pig rectum and human colon expressed α‐synuclein in their axons. α‐Synuclein‐immunoreactivity was present in 24 ± 0.7% of somatostatin (SOM)‐immunoreactive (IR) varicosities; 20 ± 4.3% of substance P (SP)‐IR varicosities and 9 ± 1.3% vasoactive intestinal polypeptide (VIP)‐IR varicosities in guinea pig rectal myenteric ganglia. However, α‐synuclein‐immunoreactivity was localized in significantly more vesicular acetylcholine transporter (VAChT)‐IR varicosities (88 ± 3%,P< 0.001). Of SOM‐IR, SP‐IR, and VIP‐IR varicosities that lacked VAChT‐immunoreactivity, only 1 ± 0.3%, 0 ± 0.3%, and 0% contained α‐synuclein‐immunoreactivity, respectively. 71 ± 0.8% of VAChT‐IR varicosities in myenteric ganglia of human colon were α‐synuclein‐IR. In guinea pig rectal myenteric ganglia, α‐synuclein‐ and VAChT‐immunoreactivity coexisted in 15 ± 1.4% of biotinamide‐labeled extrinsic varicosities; only 1 ± 0.3% of biotinamide‐labeled extrinsic varicosities contained α‐synuclein‐immunoreactivity without VAChT‐immunoreactivity. α‐Synuclein expression in axons to the distal gut correlates closely with expression of the cholinergic marker, VAChT. This is the first report of cell‐selective α‐synuclein expression in the nervous system. Our results suggest cholinergic neurons in the gut may be vulnerable in Parkinson's disease. J. Comp. Neurol. 521:657–676, 2013. © 2012 Wiley Periodicals, Inc.
Semantic link‐based constructing of multi‐dimensional service resource space for collaboration
Authors: Zhao Anping , Ma Yan 
Published: July 2012

ABSTRACTAutomatic service collaboration calls for the development of semantically structured service resource space to maximize the utility of Web services. Semantic links contain rich semantic information that may indicate important relationships among services. We provided an effective method for constructing multi‐dimensional service resource space based on semantic links for service collaboration, in which similar and related semantic relationship between services are considered. We first clustered services with similar and related relations on the basis of a hierarchical structure respectively and then took advantage of the resource space model to construct multi‐dimensional service resource space. Finally, experimental results show the effectiveness of the method. Concurrency and Computation: Practice and Experience, 2012.© 2012 Wiley Periodicals, Inc.
Spectral Diffusion of Single Dibenzoterrylene Molecules in 2,3‐Dimethylanthracene
Authors: Tian Yuxi , Navarro Pedro , Kozankiewicz Boleslaw , Orrit Michel 
Published: July 2012

AbstractWe study single dibenzoterrylene molecules embedded in the dipolar disordered crystal 2,3‐dimethylanthracene at 1.25 K. Broad linewidths (about 1 GHz, ∼30 times broader than in the anthracene crystal), high saturation excitation intensities (∼1000 times larger than in anthracene), as well as strong spectral diffusions are observed. Additionally, spectral jumping is studied by varying the excitation intensity and the temperature. We propose that the spectral diffusion and dynamic disorder in this system arise from the combination of a static disorder with slight reorientations of the methyl groups of the host molecules.
Structured youth dialogue to empower peacebuilding and leadership
Authors: Ungerleider John 
Published: July 2012

AbstractThrough structured dialogue during Youth Peacebuilding and Leadership Programs, high school and college students from Cyprus, Iraq, Serbia, Armenian, Azerbaijan, Denmark, the U.K., and the United States developed expressive, relational, intercultural, and analytical skills, plus a sense of personal transformation. Well‐facilitated peer dialogue promotes self‐awareness, compassion, diverse perspectives on current issues, and capacities for social action. Facilitators structure process and content for sessions, creating a mood of safety and openness, focusing topics for appropriate risk and relevance, reconciliation, and empowerment. Participants practice communication skills essential for shared leadership: listening and speaking effectively, recognizing cross‐cultural difference, analyzing issues cooperatively, and making decisions collaboratively.
Transfer up or down? Dialogue groups between Turkish and Armenian communities in the United States
Authors: Ohanyan Anna 
Published: July 2012

AbstractDrawing from four case studies of dialogue groups between Turkish American and Armenian American communities organized over the past decade, this article examines the political value of grassroots diplomacy. In particular, it questions the emphasis on the transfer‐up paradigm prevalent in the literature of conflict resolution, which is premised on the ultimate importance of governmental structures in brokering a resolution. Instead, the article focuses on the role that grassroots communities can play in civil society development between two communities as an alternate pathway toward conflict resolution and reconciliation. The article also takes up the dilemma that dialogue groups face: to promote a resolution to a conflict versus advancing social justice and human rights. The article concludes with a set of theoretical and policy recommendations.
Transesterification of Diethyl Oxalate with Phenol over Sol–Gel MoO3/TiO2 Catalysts
Authors: Kotbagi Trupti , Nguyen Duy Luan , Lancelot Christine , Lamonier Carole , Thavornprasert Kaew‐Arpha , Wenli Zhu , Capron Mickaël , Jalowiecki‐Duhamel Louise , Umbarkar Shubhangi , Dongare Mohan , Dumeignil Franck 
Published: July 2012

AbstractThe transesterification of diethyl oxalate (DEO) with phenol to form diphenyl oxalate (DPO) has been carried out in the liquid phase over very efficient MoO3/TiO2 solid‐acid sol–gel catalysts. A selectivity of 100 % with a remarkable maximum yield of 88 % were obtained, which opens the route to downstream phosgene‐free processes for the synthesis of polycarbonates. Interpretation of the results of various acidity measurements (NH3 and pyridine desorption, methanol oxidation as a probe reaction) allowed us to identify the catalytic sites as Lewis acid sites.
Effects of retinoic acid and Gbx1 on feather‐bud formation and epidermal transdifferentiation in chick embryonic cultured dorsal skin
Authors: Obinata Akiko , Akimoto Yoshihiro 
Published: July 2012

AbstractBackground: Retinoic acid, an active metabolite of retinol, is known to regulate cell proliferation, differentiation, and morphogenesis during normal development of many tissues. Using chick embryonic tarsometatarsal skin, we showed previously that the expression of Gbx1, a divergent homeobox gene, is increased in the epidermis through interaction with retinol‐pretreated dermal fibroblasts followed by epidermal transdifferentiation to mucous epithelium. This present study was performed to elucidate the effects of retinoic acid and Gbx1 on feather‐bud formation and epidermal transdifferentiation. Results: We showed that Gbx1 was expressed in the chick embryonic dorsal epidermis as early as at placode stage (Hamburger and Hamilton stage 31) and increased in amount during feather‐bud formation. Treatment with 1 μM retinoic acid for 24 hr inhibited feather‐bud formation and induced the transdifferentiation of the epidermis to a mucosal epithelium with a concomitant increase in Gbx1 mRNA expression in the epithelium. Furthermore, transient transfection of the epidermis with Gbx1 cDNA by electroporation induced elongation of the feather bud, but did not result in transdifferentiation. Conclusions: These results indicate that Gbx1 was involved in the feather‐bud formation and was one of target genes of retinoic acid and that other signals in addition to Gbx1 were required for epidermal mucous transdifferentiation. Developmental Dynamics 241:1405–1412, 2012. © 2012 Wiley Periodicals, Inc.
Microarray‐based identification of Pitx3 targets during Xenopus embryogenesis
Authors: Hooker Lara , Smoczer Cristine , KhosrowShahian Farhad , Wolanski Marian , Crawford Michael J. 
Published: July 2012

AbstractBackground: Unexpected phenotypes resulting from morpholino‐mediated translational knockdown of Pitx3 in Xenopus laevis required further investigation regarding the genetic networks in which the gene might play a role. Microarray analysis was, therefore, used to assess global transcriptional changes downstream of Pitx3. Results: From the large data set generated, selected candidate genes were confirmed by reverse transcriptase‐polymerase chain reaction (RT‐PCR) and in situ hybridization. Conclusions: We have identified four genes as likely direct targets of Pitx3 action: Pax6, β Crystallin‐b1 (Crybb1), Hes7.1, and Hes4. Four others show equivocal promise worthy of consideration: Vent2, and Ripply2 (aka Ledgerline or Stripy), eFGF and RXRα. We also describe the expression pattern of additional and novel genes that are Pitx3‐sensitive but that are unlikely to be direct targets. Developmental Dynamics 241:1487–1505, 2012. © 2012 Wiley Periodicals, Inc.
A pilot evaluation of appetite‐awareness training in the treatment of childhood overweight and obesity: A preliminary investigation
Authors: Bloom Taryn , Sharpe Louise , Mullan Barbara , Zucker Nancy 
Published: July 2012

AbstractObjective:The aim of this study was to conduct a preliminary evaluation of Children's Appetite Awareness Training (CAAT), a treatment for childhood obesity which encourages overweight children to eat in response to internal appetite cues.MethodOverweight children (ages 6–12 years old) were randomized to either the CAAT treatment group (N = 23), to receive 1‐h treatment sessions over 6 weeks, or a wait‐list group (N = 24). Weight and height of children and parents in both groups were assessed at pre‐ and post‐treatment (or equivalent time for wait‐list control) and at a 6‐month follow‐up for those in the CAATgroup.Results:The intervention had a significant, short‐term effect on the BMI of children who participated. Although at 6‐month follow‐up, children's BMI has not increased significantly, the difference between pretreatment and follow‐up BMI was no longer significant.Discussion:These results are encouraging for the use of CAAT with overweight children. Long‐term effectiveness could be enhanced through increasing the duration of the program, adding booster sessions and increased involvement of parents. © 2012 by Wiley Periodicals, Inc. (Int J Eat Disord 2013)
Absence of seasonal pattern of birth in patients with anorexia nervosa
Authors: Vellisca María Y. , Latorre José I. , Santed Miguel A. , Reales José M. 
Published: July 2012

AbstractObjective:An excess of spring births has been suggested in patients with anorexia nervosa (AN), especially in the restricting subtype, but most of the research has been carried out inside the United Kingdom. The aim of this study was to assess whether there is a seasonal pattern of birth in a representative sample of patients with AN in a different latitude in the northern hemisphere.Method:We examined the month of birth in a sample of 210 female patients with a DSM‐IV diagnosis of AN at first presentation to a specialized eating disorders service in Spain.Results:We found no evidence of significant variation in month or season of birth in AN when compared to general population.Discussion:There is not enough evidence of a season of birth bias under the latitude of the United Kingdom in the risk of developing AN. © 2012 by Wiley Periodicals, Inc. (Int J Eat Disord 2013)
The disappearing northern leopard frog (Lithobates pipiens): conservation genetics and implications for remnant populations in westernNevada
Authors: Rogers Serena D. , Peacock Mary M. 
Published: July 2012

AbstractGlobal amphibian declines suggest a major shift in the amount and quality of habitat for these sensitive taxa. Many species that were once widespread are now experiencing declines either in part of or across their historic range. The northern leopard frog (Rana[Lithobates]pipiens] has undergone significant declines particularly in the westernUnitedStates andCanada. Leopard frog population losses inNevada are largely due to habitat fragmentation and the introduction of nonnative fish, amphibian, and plant species. Only two populations remain in theTruckee andCarsonRiver watersheds of westernNevada which represents the western boundary of this species range. We used sequence data for an 812 base pair fragment of the mitochondrialNADHdehydrogenase 1 (ND1) gene to support a native origin for westernNevada populations. All frogs had a single haplotype (W07) from the distinct westernNorthAmericaND1 haplotype clade. Data from seven polymorphic microsatellite loci show thatTruckee andCarsonRiver populations are highly differentiated from each other and from leopard frogs collected from easternNevada sites. Lack of gene flow among and distinct color morphs among the westernNevada populations likely predates the current geographical isolation. Comparisons with other peripheralL. pipienspopulations show westernNevada populations have similar levels of gene diversity despite their contemporary isolation (HE0.411, 0.482). Restoration of leopard frog populations in these watersheds will be challenging given well‐entrenched nonnative bullfrog populations and major changes to the riparian zone over the past century. Declines of once common amphibian species has become a major conservation concern. Contemporary isolation of populations on a species range periphery such as the leopard frog populations in theTruckee andCarson rivers further exacerbate extirpation risk as these populations are likely to have fewer genetic resources to adaptively respond to rapidly changing biotic and abiotic environments.
From Coordination Polymers to Doped Rare‐Earth Oxides
Authors: Demars Thomas , Boltoeva Maria , Vigier Nicolas , Maynadié Jérôme , Ravaux Johann , Genre Caroline , Meyer Daniel 
Published: July 2012

AbstractA series of bimetallic coordination polymers were synthesised from lanthanide salts (chlorides or nitrates of Ce, Nd, Gd) and 2,5‐dihydroxy‐1,4‐benzoquinone (DHBQ) under aqueous and anhydrous conditions, to be used as preceramics for mixed oxide synthesis. Syntheses in water or tetrahydrofuran (THF) gave rise to two different types of metal–organic frameworks. A new polymeric species, [Gd(DHBQ)Cl(THF)2]n, was characterised by single‐crystal X‐ray diffraction {[Gd(DHBQ)Cl(THF)2]n, a = 8.643(2) Å, b = 9.917(5) Å, c = 10.422(3) Å, α = 104.611(3)°, β = 109.623(3)°, γ = 96.097(3)°, V = 796.1(5) Å3, triclinic, P$\bar {1}$, Z = 2}. Characterisation by IR and Raman spectroscopy, powder X‐ray diffraction and scanning electron microscopy showed that the mixed‐metal polymers are solid solutions and highlighted the fact that their shape and morphology are strongly influenced by the presence of water in the reaction mixture. Micrometric, well‐defined cylindrical objects were obtained from the aqueous synthesis, while the reaction in anhydrous THF led to nanometric spheres. Calcination at 850 °C of the coordination polymer preceramics easily yielded mixed NdxGd(1–x) and NdxCe(1–x) oxides as solid solutions, in which x varies between 0 and 1. The morphology of the preceramic powders is retained upon calcination. This allows easy control of some of the oxide properties from the coordination compound synthesis step. Indeed, BET measurements pointed out that the choice of anhydrous reaction conditions for the preceramic synthesis leads to enhancement of the specific surface areas of the oxides by one order of magnitude.
Luminescent AuI–CuI Triphosphane Clusters That Contain Extended Linear Arylacetylenes
Authors: Shakirova Julia R. , Grachova Elena V. , Melekhova Anna A. , Krupenya Dmitrii V. , Gurzhiy Vladislav V. , Karttunen Antti J. , Koshevoy Igor O. , Melnikov Alexei S. , Tunik Sergey P. 
Published: July 2012

AbstractReactions of the [(tppm)Au3Cl3] [tppm = tris(diphenylphosphanyl)methane] precursor and CuI ions with a stoichiometric amount of the corresponding linear mono‐ [HC2(C6H4)nC6H5; n = 1, 2] and diacetylenes [HC2(C6H4)nC2H; n = 1–3] that contain extended polyaryl moieties afford a series of luminescent heterometallic complexes with a common structural motif based on the {(AuC2)3Cu} cluster core. The complexes obtained were characterized by using X‐ray crystallography and NMR spectroscopy. All compounds studied display dual singlet and triplet luminescence, the former component of which can be completely suppressed in concentrated solution by a self‐absorption phenomenon. The results of the photophysical measurements together with the quantum chemical calculations (PBE0‐DFT level of theory) indicate that singlet emission originates mainly from copper‐perturbed intraligand transitions, whereas the phosphorescence can be assigned to the {(AuC2)3Cu} core‐centered transitions. Due to the low contribution of the gold atoms to the orbitals responsible for the singlet and triplet emission, the emissive excited states are very weakly coupled, thereby resulting in a negligible energy transfer between these excited states.
Heterogeneous Bifunctional Metal/Acid Catalysts for Selective Chemical Processes
Authors: Barbaro Pierluigi , Liguori Francesca , Linares Noemi , Marrodan Carmen Moreno 
Published: July 2012

AbstractHeterogeneous catalysts enabling multiple reaction sequences in one pot have a great potential for large‐scale production processes in terms of productivity, cost‐effectiveness, and low environmental impact. This paper reviews the most representative examples and the recent achievements in the field of solid bifunctional metal/acid‐site catalysts and their application to the production of fine chemicals through selective, cooperative, or sequential processes in single reactor units. The literature that appeared from January 2009 to January 2012 is covered.
Homotypic cell cannibalism, a cell‐death process regulated by the nuclear protein 1, opposes to metastasis in pancreatic cancer
Authors: Cano Carla E. , Sandí María José , Hamidi Tewfik , Calvo Ezequiel L. , Turrini Olivier , Bartholin Laurent , Loncle Céline , Secq Véronique , Garcia Stéphane , Lomberk Gwen , Kroemer Guido , Urrutia Raul , Iovanna Juan L. 
Published: July 2012

AbstractPancreatic adenocarcinoma (PDAC) is an extremely deadly disease for which all treatments available have failed to improve life expectancy significantly. This may be explained by the high metastatic potential of PDAC cells, which results from their dedifferentiation towards a mesenchymal phenotype. Some PDAC present cell‐in‐cell structures whose origin and significance are currently unknown. We show here that cell‐in‐cells form after homotypic cell cannibalism (HoCC). We found PDAC patients whose tumours display HoCC develop less metastasis than those without. In vitro, HoCC was promoted by inactivation of the nuclear protein 1 (Nupr1), and was enhanced by treatment with transforming growth factor β. HoCC ends with death of PDAC cells, consistent with a metastasis suppressor role for this phenomenon. Hence, our data indicates a protective role for HoCC in PDAC and identifies Nupr1 as a molecular regulator of this process.
Genetic and environmental factors in late onset dementia: possible role for early parental death
Authors: Whalley Lawrence J. , Staff Roger T. , Murray Alison D. , Deary Ian J. , Starr John M. 
Published: July 2012

ObjectiveWe aimed to investigate three reports of a possible role of early parental death in late onset dementia. We tested a multivariate model of risk factors for late onset dementia that included established (female sex, a family history of dementia, APOE ε4) and putative influences (vascular risk factors, years of full‐time education, parental ages at death, and childhood IQ) on dementia risk.MethodsWe examined contributions of early life and late life risk factors for dementia by using childhood social and family data and blood samples obtained at interview at age about 78 years. In 1997–1999, we recruited 281 subjects without dementia from a 1932 Scottish IQ survey of children born in 1921 and followed them up to 2010 (at age 88). Binary logistic regression and Bayesian structural equation modelling were used to model dementia risk.ResultsRisk of dementia was associated with increasing age from 77 to 88 years, female sex, death of either parent before age 11 and APOE ε4 genotype. Family history of dementia, childhood IQ, years of education and vascular risk factors did not contribute to the model.ConclusionsOur multivariate models of the possible causes of late onset dementia confirm previous associations of dementia with female sex and APOE ε4 genotype and supports earlier reports of a role for early parental death. Copyright © 2012 John Wiley & Sons, Ltd.