bluuebunny/crossref_metadata_2025_split huggingface dataset:
Are they listening to my voice?
Authors: Fikry Amily 
Published: December 2011

PurposeThis paper aims to describe the ways to market electrical and electronic household appliances to the teenagers market.Design/methodology/approachThe paper reviews the debate and key statistical insights on Malaysian teenagers are described to show the overview of the current scenario in Malaysia. Various marketing strategies are suggested to market electrical and electronic household appliances to the teenagers market.FindingsThe paper finds that there is a need to listen to the needs and wants of these teenagers. Marketers are then able to direct their marketing strategies to fulfill the needs and wants of these teenagers segment.Research limitations/implicationsResults are limited to practitioners involved in the electrical and electronic household appliances industries only.Practical implicationsManagerial implications suggest several strategies to market electrical and electronic household appliances to these teenagers, with a great emphasis on the impact of technological means towards the teenagers market.Originality/valueNew technological approaches are proposed as a means to market electrical and electronic household appliances to the teenagers market. Previously, the importance of teenagers' influence on the purchase of electrical and electronic household appliances has been largely ignored due to an underestimate of these young consumers' power.
Adopting TQM approach to achieve customer satisfaction
Authors: Kristianto Yohanes , Ajmal Mian M. , Sandhu Maqsood 
Published: December 2011

PurposeThe purpose of this paper is to present the results of a survey of customer satisfaction with regard to the strategy of total quality management (TQM) adopted in a wheat flour milling company.Design/methodology/approachA survey was conducted to learn more about customer expectations and satisfaction. The respondents were all customers of a flour‐based food processor. Quality function deployment (QFD) was applied to improve customer service performance by focusing on customer satisfaction, value and retention.FindingsThe results show that customer satisfaction has increased steadily over a period of three years. The QFD approach helped to design a competitive product by aligning the company resources to customers’ needs.Research limitations/implicationsThe findings are limited to a specific food manufacturing company and for this reason they cannot be generalized to the whole in service sector. Further research is needed for other service companies.Practical implicationsThe findings may support manufacturing companies hoping to achieve customer satisfaction by focusing on TQM implementation efforts. Furthermore, companies can focus their efforts on improving the way in which they meet certain customers’ needs if these needs are more extensively related to a certain component of quality management.Originality/valueThe paper presents evidence to managers of the value of implementing TQM strategy to effectively achieve customer satisfaction that ultimately leads to greater market share and profit maximization.
Higher education regionalization in Asia Pacific
Authors: Neubauer Deane 
Published: December 2011

PurposeThe purpose of this paper is to outline some of the historic ways of reviewing patterns of regional engagement, with special attention to how the emergent concepts of higher education (HE) regionalization stand in relationship to regionalism. Additional implications are spelled out for governance, citizenship and university transformation.Design/methodology/approachThis conceptual essay is meant to appear in conjunction with more discrete, case‐oriented examinations of Asia Pacific HE regionalization.FindingsDiscussions of regionalism in Asian HE are being replaced by those focused on regionalization; the former is a nation‐state and geographic policy framework whereas the latter tends to refer to emergent empirical relationships. Regionalization itself can be further distinguished in terms of its “older” forms, focused on geographic proximities and exchanges defined and carried out within those proximities. New regionalization is increasingly linked to global circuits of exchange in which the currencies of such exchanges are closely linked to the emergent dynamics of the knowledge society and economy. These dynamics in turn are closely linked to patterns of migration and mobility in HE and the efforts of higher education institutions (HEIs) and regional governments to develop new governance structure structures appropriate for this style of regionalization. These regional dynamics reflect tensions that draw institutions and nations together (centripetal forces) and those that keep them apart (centrifugal forces). These processes are marked by governance dynamics, those of affinity and affiliation, transnational innovation, and redefinitions of the responsibilities and promises of citizenship.Originality/valueUse of these modal concepts can be used to promote and extend a region‐wide discussion and related research relevant to HE transformation within the region.
Regional cooperation in higher education in Asia and the Pacific
Authors: Lee Molly N.N. 
Published: December 2011

PurposeThe purpose of this paper is to present a general overview of the kinds of regional cooperation that are commonly found in the higher education (HE) sector among countries in Asia and the Pacific.Design/methodology/approachThe research methodology is literature review, collecting primary data from the web sites set up by the various organizations that are being reviewed.FindingsThe types of university exchanges can be broadly categorized as academic exchange, research collaboration and university‐community engagement. Some of the regional cooperation are initiated by intergovernmental organizations while others are initiated by non‐governmental organizations. The paper reviews intergovernmental initiatives by UNESCO, SEAMEO RIHED, ASEAN, ASEM, EAS, and APEC. It also reviews several higher education networks including ASAHIL, UMAP, APRU, AUF, AAOU and APAIE, as well as two regional initiatives, APQN and the UNESCO Regional Convention on the Recognition of Studies, Diplomas and Degrees in Higher Education in Asia and the Pacific.Originality/valueThis is an original piece of analytical work on the roles and functions of various HE organizations and networks in the Asia‐Pacific region.
Exporting Filipino graduates to the global labor market
Authors: Ordonez Regina M. 
Published: December 2011

PurposeThe purpose of this paper is to present the need for quality reform in the Philippine higher education “industry,” given the challenges of Government regulators on the one hand, and college degree holders on the other, in meeting international standards necessary to compete in the global labor market.Design/methodology/approachAside from selected academic articles focusing on the interplay between Philippine higher education and the global market, interviews with key players validated and rounded off the findings and conclusions drawn.FindingsThe marketplace of higher education institutions today is driven largely by profit seeking, whose indiscriminate growth as an industry has brought into question the quality of educational offerings for students whose dream of working abroad for potentially higher incomes may be frustrated by their unpreparedness in meeting global job requirements, despite their academic training in higher education institutions.Originality/valueThis paper is one more call for the Commission on Higher Education and its accreditation partners to insist on enforcing international standards and best practices in education upon tertiary institutions of learning in the country, even if it means closure of programs or even schools. This requires political will.
Possibility of East Asian integration through the regional networks and universities’ cooperation in higher education
Authors: Sugimura Miki 
Published: December 2011

PurposeThe purpose of this paper is to clarify the function and issues of intra‐ and inter‐regional cooperation of international higher education in Asia and consider the possibility of East Asian integration as regionalization.Design/methodology/approachThe research consists of two steps. First, by comparing with examples of regional networks and universities’ cooperation programs, it breaks down the current situation of regional cooperation. Second, it analyses the structure of those networks and programs.FindingsBoth regional education networks and universities’ cooperation programs develop in multi‐layers and in different phases, and they have a function of distribution of Asian higher education as public goods for regionalization. There are still issues such as immigration control relating to the people's and programs’ mobility, program language, financial and personnel affairs, as well as adjustments to be made in accreditation assessment, credit compatibility and quality assurance including curriculum setting. Retaining the autonomy of countries and higher education agencies in international cooperation is also the major issue in promoting these programs. However, such international cooperation produces the new forms of international higher education for human resource development.Research limitations/implicationsNot all networks and programs can be examined, but the trend and characteristics of the cooperation in higher education can be highlighted.Practical implicationsThe findings give significance to the “Campus Asia” concept which is now in preparation for realization by the agreement at the summit of China, Japan and South Korea in October 2009.Originality/valueWhile integration and regionalization in East Asia has been discussed previously from the political and economic aspects, this paper responds to the subject from the socio‐cultural aspect by focusing on international higher education in Asia.
Targeted therapy in prostate cancer
Authors: Corcoran Niall M , Gleave Martin E 
Published: December 2011

Corcoran N M & Gleave M E  (2012) Histopathology60, 216–231Targeted therapy in prostate cancerThe therapeutic approach to advanced prostate cancer has seen greater changes in the last 7 years than it did in the preceding 70. Although only one of the newly approved agents that improve overall survival is a targeted agent, it is a validation of the method of pathway analysis and drug design in delivering novel, clinically usable agents. As our knowledge of the molecular circuitry of tumour invasion, metastases and treatment resistance has become more refined, the number of new, potentially useful, targets has grown exponentially. This is reflected in the vast array of diverse targeted agents that are currently being evaluated in human trials. In this review, we briefly describe some of the key pathways that are involved in the evolution of the prostate cancer ‘lethal phenotype’, and review the clinical activity of some of the newly approved targeted therapies or those in advanced phases of clinical development.
Histological variants of prostatic carcinoma and their significance
Authors: Humphrey Peter A 
Published: December 2011

Humphrey P A  (2012) Histopathology60, Histological variants of prostatic carcinoma and their significanceThe vast majority of prostatic cancers are acinar adenocarcinomas. Histological variants of prostatic carcinoma have been variably defined. One approach is to consider two groups of variants. The first group comprises histological variants of acinar adenocarcinoma and the second group non‐acinar carcinoma variants or types. Variants of usual acinar adenocarcinoma defined in 2004 by the World Health Organization (WHO) include atrophic, pseudohyperplastic, foamy, colloid, signet ring, oncocytic and lymphoepithelioma‐like carcinomas. The second group of non‐acinar carcinoma histological variants or types of prostatic carcinoma accounts for about 5–10% of carcinomas that originate in the prostate. These include sarcomatoid carcinoma, ductal adenocarcinoma, urothelial carcinoma, squamous and adenosquamous carcinoma, basal cell carcinoma, and neuroendocrine tumours, specifically small‐cell carcinoma. Recently characterized variants not present in the 2004 WHO classification, including microcystic adenocarcinoma, prostatic intraepithelial neoplasia‐like adenocarcinoma, large‐cell neuroendocrine carcinoma, and pleomorphic giant cell carcinoma, are also described. The aims of this review are to present the essential histomorphological diagnostic attributes of these variants, and to emphasize the clinical signficance of the variants, when different from usual acinar adenocarcinoma, including clinical presentation and outcome.
Pathology and virology findings in cases of fatal influenza A H1N1 virus infection in 2009–2010
Authors: Bal Amanjit , Suri Vikas , Mishra Baijayantimala , Bhalla Ashish , Agarwal Ritesh , Abrol Anil , Ratho Radha Kanta , Joshi Kusum 
Published: December 2011

Bal A, Suri V, Mishra B, Bhalla A, Agarwal R, Abrol A, Ratho R K & Joshi K  (2012) Histopathology 60, 326–335  Pathology and virology findings in cases of fatal influenza A H1N1 virus infection in 2009–2010Aims:  To describe the pathological findings, immunohistochemical localization of viral antigen and tissue reverse transcriptase polymerase chain reaction (RT‐PCR) findings of different organs in cases of fatal H1N1 influenza virus infection from North India.Methods and results:  Nine patients positive for H1N1 virus by a throat swab real‐time RT‐PCR (rRT‐PCR) were included. Underlying risk factors included pregnancy, respiratory diseases, rheumatic heart disease, and chronic kidney disease. Pathological evidence of tracheitis, necrotizing bronchiolitis and diffuse alveolar damage was noted in all of the cases. Influenza viral antigen was observed by immunohistochemistry in the epithelium of the tracheobronchial tree, bronchial glands, gland ducts, and, less frequently, the alveolar epithelial cells. Viral particles were confirmed by electron microscopy in three autopsy cases. Tissue rRT‐PCR for H1N1 viral RNA was positive in lung samples, but negative in other organs. Secondary bacterial pneumonia, cytomegalovirus infection and angio‐invasive zygomycosis were detected.Conclusions:  The pulmonary findings are similar to those described in past pandemics. Secondary fungal and viral infections, which have not been reported previously, were noted. Although the number of cases in this study is small, the findings reinforce the notion that changes in extrapulmonary organs are attributable to multiorgan dysfunction syndrome rather than a viral cytopathic effect, and that there is no transplacental transmission of virus.
Diagnostic and prognostic molecular biomarkers for prostate cancer
Authors: Kristiansen Glen 
Published: December 2011

Kristiansen G  (2012) Histopathology 60, 125–141Diagnostic and prognostic molecular biomarkers for prostate cancerProstate cancer is the most common malignant tumour in men and is a major research focus of pathologists, urologists and uro‐oncologists alike. The pathologist is confronted with an increasing number of biospsies, necessitating ancillary tests in morphologically challenging cases. Next to basal cell markers, additional positive markers that aid in the differential diagnosis are presented here. The clinical decision of urologists, whom and how to treat these men, is dependent predominantly on pathological parameters, but still the grid spanned by these is too wide to allow a sufficient prognostication of the individual case. Here, a brief and critical overview is given of recent developments of prognostic biomarkers in prostate cancer.
Intramucosal variant of nasal natural killer (NK)/T cell lymphoma has a better survival than does invasive variant: implication on loss of E26 transformation‐specific sequence 1 (ETS‐1) and T‐box expressed in T cells (T‐bet) with invasion
Authors: Lin Ting‐Chu , Chen Shee‐Uan , Chen Ya‐Fang , Chang Yeun‐Chung , Lin Chung‐Wu 
Published: December 2011

Lin T‐C, Chen S‐U, Chen Y‐F, Chang Y‐C & Lin C‐W  (2012) Histopathology 60, 287–295  Intramucosal variant of nasal natural killer (NK)/T cell lymphoma has a better survival than does invasive variant: implication on loss of E26 transformation‐specific sequence 1 (ETS‐1) and T‐box expressed in T cells (T‐bet) with invasionAims:  Nasal natural killer/T cell lymphoma (NNKTCL) arises from the nasal mucosa, and spreads to adjacent tissues via local invasion or to regional lymph nodes and distant sites via metastasis. The aims of this study were to determine the impact of invasion on the prognosis of NNKTCL, and correlate invasion with the expression of cytotoxic markers of lymphoma cells.Methods and results:  Histopathological evaluations of invasion and immunohistochemistry for cytotoxic markers, including E26 transformation‐specific sequence 1 (ETS‐1), T‐box expressed in T cells (T‐bet), signal transducer and activator of transcription (STAT‐1), CD56 and granzyme B (GB), were performed in 64 NNKTCLs. There were 17 stage I cases without invasion (stage Ia or intramucosal), 21 stage I cases with invasion (stage Ib), 16 stage II cases and 10 stages III/IV cases. Stage Ia NNKTCLs had a better 5‐year overall survival rate than that of stages Ib, II or III/IV NNKTCLs (85%, 38%, 33% and 20%, respectively, P < 0.001 by log‐rank test). Loss of ETS‐1 was found in 24% (four of 17) stage Ia NNKTCLs and in 65% (28 of 43) stages Ib/II/III/IV NNKTCLs (P = 0.04, Fisher’s exact test); loss of T‐bet was found in 29% (five of 17) stage Ia NNKTCLs and in 67% (30 of 45) stages Ib/II/III/IV NNKTCLs (P = 0.02, Fisher’s exact test).Conclusions:  NNKTCL is classically an aggressive lymphoma, but the intramucosal variant is less aggressive. Loss of ETS‐1 or T‐bet correlated weakly with invasion, a finding that requires further confirmation.
Presence of cytogenetic abnormalities in Spitz naevi: a diagnostic challenge for fluorescence in‐situ hybridization analysis
Authors: Martin Vittoria , Banfi Sara , Bordoni Andrea , Leoni‐Parvex Sandra , Mazzucchelli Luca 
Published: December 2011

Martin V, Banfi S, Bordoni A, Leoni‐Parvex S & Mazzucchelli L  (2012) Histopathology 60, 336–346  Presence of cytogenetic abnormalities in Spitz naevi: a diagnostic challenge for fluorescence in‐situ hybridization analysisAims:  Spitz naevi are difficult to diagnose, because of significant overlap with melanomas. It has been recently demonstrated that the LSI RREB1(6p25)/LSI MYB(6q23)/LSI CCND1(11q13)/CEP6 fluorescence in‐situ hybridization (FISH) assay is a reliable tool with which to distinguish benign naevi and melanomas. Little is known about its diagnostic usefulness in Spitz naevi.Methods and results:  We investigated 51 patients with Spitz naevi and long‐term median follow‐up (8.18 years) with the multicolour FISH probe. Control groups included 11 benign naevi and 14 melanomas. Spitz naevi from 32 (63%) patients did not show cytogenetic abnormalities (FISH−). In contrast, Spitz naevi from 19 (37%) patients showed changes in the investigated loci (FISH+). Spitz naevi with the FISH+ profile showed chromosome X polysomy in 14/18 (78%) patients. All Spitz naevi with the FISH− profile were disomic. All melanomas displayed a FISH+ profile, and 4/11 (36%) showed chromosome X polysomy. No differences in clinicopathological features were detected between Spitz naevi with and without genetic abnormalities.Conclusions:  The presence of gene copy number changes in Spitz naevi as detected by FISH is higher than expected, and Spitz naevi at the genetic level represent a heterogeneous group. The findings of similar cytogenetic alterations in Spitz naevi and melanomas suggest that there should be cautious interpretation of FISH analysis in this setting.
Ocular adnexal IgG4‐related disease: comparative analysis with mucosa‐associated lymphoid tissue lymphoma and other chronic inflammatory conditions
Authors: Go Heounjeong , Kim Ji Eun , Kim Young A , Chung Ho Kyung , Khwarg Sang In , Kim Chul‐Woo , Jeon Yoon Kyung 
Published: December 2011

Go H, Kim J E, Kim Y A, Chung H K, Khwarg S I, Kim C‐W & Jeon Y K  (2012) Histopathology 60, 296–312  Ocular adnexal IgG4‐related disease: comparative analysis with mucosa‐associated lymphoid tissue lymphoma and other chronic inflammatory conditionsAims:  Making a differential diagnosis of IgG4‐related disease from mucosa‐associated lymphoid tissue (MALT) lymphoma or any other chronic inflammation is often challenging. Moreover, the association with secondary lymphoma of ocular adnexal IgG4‐related disease needs to be elucidated.Methods and results:  We investigated 14 cases of IgG4‐related disease, nine MALT lymphomas and 12 other chronic inflammations involving the lacrimal gland and orbit. Bilateral involvement was frequent in IgG4‐related diseases. The number of IgG4‐positive cells and the ratio of IgG4/IgG‐positive cells were higher in patients with IgG4‐related disease than in those with MALT lymphoma (P = 0.016; P < 0.001) and other types of inflammation (P < 0.001; P < 0.001). Monoclonal B cell proliferation was suspected in two cases (14.3%) of IgG4‐related disease. One of these patients also displayed monomorphous features suggesting secondary MALT lymphoma. In the other case, κ‐chain restriction in IgG4‐positive cells was observed, raising the possibility of IgG4‐producing MALT lymphoma. Trisomy 3, trisomy 18 or MALT1 translocation was observed in none of the IgG4‐related cases. Regulatory T‐cell infiltration was higher in cases of IgG4‐related disease than in MALT lymphomas (P < 0.001) and other types of inflammation (P = 0.006).Conclusions:  Some genetically and morphologically complicated cases of ocular adnexal IgG4‐related disease emphasize the need for in‐depth studies to differentiate this disease from MALT lymphoma, and to exclude secondary lymphoma.
Insulin‐like growth factor II mRNA‐binding protein 3 (IMP3) expression in hepatocellular carcinoma. A clinicopathological analysis with emphasis on diagnostic value
Authors: Wachter David L , Kristiansen Glen , Soll Christopher , Hellerbrand Claus , Breuhahn Kai , Fritzsche Florian , Agaimy Abbas , Hartmann Arndt , Riener Marc‐Oliver 
Published: December 2011

Wachter D L, Kristiansen G, Soll C, Hellerbrand C, Breuhahn K, Fritzsche F, Agaimy A, Hartmann A & Riener M‐O  (2012) Histopathology 60, 278–286  Insulin‐like growth factor II mRNA‐binding protein 3 (IMP3) expression in hepatocellular carcinoma. A clinicopathological analysis with emphasis on diagnostic valueAims:  Patients with hepatocellular carcinoma (HCC) usually present with advanced disease and rarely qualify for curative therapy. Immunohistochemical markers that help to discriminate benign from malignant processes early, and that have prognostic significance, would be useful. Expression of the oncofetal protein insulin‐like growth factor II mRNA‐binding protein 3 (IMP3) in malignant cells of different tumour types correlates with reduced overall survival.Methods and results:  Tissue microarrays (TMAs) containing 55 normal liver samples, 365 HCCs (122 with corresponding non‐tumorous liver), 10 hepatocellular adenomas, 13 focal nodular hyperplasias and nine dysplastic nodules from western European patients were stained for IMP3. IMP3 was analysed in 61 core needle biopsies and findings were compared to glypican‐3 and CD34. HCCs in TMAs were strongly positive for IMP3 in 18.4% of cases compared to absent expression in normal and non‐tumorous liver tissue and benign liver tumours. Patients with IMP3 expression in HCCs showed significantly poorer overall survival in multivariate analysis (P = 0.044). Of the 61 core needle biopsies analysed, 32 (52.5%) of the HCCs were IMP3‐positive.Conclusions:  In core needle biopsies, IMP3 expression seems to be of limited use as a single marker for the diagnosis of HCC, given a sensitivity of 52%, but it may be helpful in combination with other markers.