bluuebunny/crossref_metadata_2025_split huggingface dataset:
Combined application of resistance inducer and Trichoderma control two tobacco soil‐borne diseases by regulating the field soil microbial composition
Authors: Xia Xianren , Wang Quanzhen , Guo Kai , Yuan GuoQin , Deng Tao , Zhao Zhenyu , Guo Qichao , Wu Kai , Chen Biao , Pan Yihong 
Published: June 2024

AbstractTobacco black shank (TBS) and tobacco root black rot (TRBR) are two of the most devastating tobacco soil‐borne diseases that threaten sustainable tobacco planting. This study investigated the effects of Trichoderma sp. and a resistance inducer (RI) extracted from traditional Chinese medicine, individually or in combination, on the control of TBS and TRBR. The results showed that the application of Trichoderma sp. and RI, individually or in combination, significantly controlled the two soil‐borne diseases by significantly affecting the bacterial, but not fungal, Shannon and Simpson diversity indexes. The disease indexes of TBS and TRBR in integrated application management were the lowest, resulting in the highest potassium contents in the tobacco leaves. The control efficacies of TBS and TRBR in the integrated application treatment were 71.52 ± 1.43% and 68.33 ± 0.69%, respectively. The integrated treatment altered the composition of the rhizosphere soil microbial community. The bacterial community, but not the fungal community, of the control treatment was separated from those of other treatments. The relative abundance of bacteria involved in chemoheterotrophy and fermentation in the control treatment increased, whereas that of bacteria involved in nitrification and aerobic ammonia oxidation decreased compared with the other treatments. Importantly, the application of Trichoderma sp. and RI, individually or in combination, clearly increased the relative abundance of saprotrophic fungi in contrast to the control treatment, while decreasing that of pathotrophic fungi. Our study suggests that a suitable integrated application of bioagents and RI has synergistic effects on the suppression of two tobacco soil‐borne diseases by altering the rhizosphere microbiome composition in the field.
Gendered personal nationalism: National cause as a resource of self‐construction in Finnish nineteenth‐century letters
Authors: Eiranen Reetta 
Published: June 2024

AbstractThe article studies the personal experience and meaning of nationalism for Finnish mid‐nineteenth‐century national protagonists from the gender perspective. Using the concept of personal nationalism and the group biographical approach, the article analyses experiential and narrative self‐construction in the correspondence exchanged between members of the key family of the contemporary Finnish national circles, the Tengströms. I argue that nationalism had a deep personal, even existential, meaning for these people. However, there were differences in the ways men and women could tap into nationalism as a resource of self‐construction and in the ways they could embody and express their personal nationalism. The national meanings were, in the end, somehow branded as masculine. Men tied the national cause intensively and explicitly to their entire existence, for instance, through emotional friendships and nationalised careers. Women had to use detours, like constructing proper national womanhood through countertypes and mediating their national engagement through men.
Aquaponics in schools: Hands‐on learning about healthy eating and a healthy planet
Authors: Kluczkovski Alana , Ehgartner Ulrike , Pugh Emily , Hockenhull Imogen , Heaps‐Page Rachel , Williams Abigail , Thomas Jens M. H. , Doherty Bob , Bryant Maria , Denby Katherine 
Published: June 2024

AbstractOur food system is giving rise to a growing social, health and environmental crisis. Much of the food consumed in the United Kingdom is cheap, nutrient‐poor and highly processed, leading to under‐consumption of essential foods such as grains, beans, vegetables and fruit. This has contributed to a rise in diet‐related diseases, with approximately 22% of primary school leavers being overweight or obese. Food production is unsustainable with agriculture responsible for 10% of the UK's greenhouse gas emissions and intensive farming practices have led to a significant loss of soil carbon and a decline in biodiversity. COVID‐19 increased inequalities in our food system. Therefore, there is an urgent need for interventions to counteract these adverse social, health and environmental impacts. Education can play a crucial role as an intervention to address challenges in the food system. We tested an innovative school initiative using portable aquaponic pods and aligned to the national curriculum, to engage pupils in food production and foster learning about sustainability, climate change and healthy eating. The evaluation, based on teacher surveys, aquapod chart data, student blogs and postcards and feedback from the development team, revealed positive impacts on students’ environmental awareness, as well as sustainability and practical food production knowledge. However, the programme encountered logistical challenges and we therefore highlight future improvements to produce a curriculum programme that can be delivered at scale to enhance food education and empower pupils to drive the agenda on tackling food sustainability and climate change.
Complicated obstructive uropathy after kidney biopsy: A case report highlighting the risk of biopsy‐related acute kidney injury in a patient with unilateral kidney hypoplasia
Authors: Tsai Chi‐Huan , Tang Yu‐Shuo , Cheng Chung‐Yi , Hong Wei‐Tse 
Published: June 2024

AbstractUnilateral kidney hypoplasia is a congenital condition characterized by the underdevelopment of one kidney. Although often asymptomatic, it can cause severe renal complications in patients combined with contralateral renal injury, leading to acute renal failure. This case report describes a patient with unilateral kidney hypoplasia who underwent a kidney biopsy on the contralateral normal‐sized kidney and subsequently developed oliguric acute kidney injury. This report discusses the challenges encountered while diagnosing and managing this rare case, highlighting the importance of awareness and recognition to perform timely intervention and optimize the patient's outcome.
Pyroptosis: A major trigger of excessive immune response in the gingiva
Authors: Xiang Xueyu , Zhang Jing , Yue Yuan 
Published: June 2024

AbstractObjectivesThe gingival mucosal barrier, an important oral cavity barrier, plays a significant role in preventing pathogenic microorganism invasion and maintaining periodontal tissue health. Pathogenic microorganism invasion of the gingival mucosa produces a large number of cytokines. Among them, pyroptosis is an important player in exacerbating immune‐inflammatory responses, leading to tissue destruction. However, the mechanism of pyroptosis and the immune response it triggers have not been fully elucidated. We provide an overview of recent advances in understanding gingival physical barrier pyroptosis and inflammation‐induced hyperimmunity.MethodsPubMed, Web of Science databases were searched for articles, reviews, and clinical studies published until March 2024.ResultsWe summarised the importance of the gingival barrier in terms of the functions of different cells, described the progress in research on gingival epithelial cell and gingival fibroblast pyroptosis and the immune‐inflammatory response it induces, and discussed the relationship between pyroptosis and systemic diseases, association of multiple cell death systems. Finally, we propose future directions for pyroptosis research.ConclusionsPyroptosis often triggers a range of inflammatory immune responses that lead to associated diseases. Therefore, further study of the molecular mechanisms of pyroptosis and the immune responses is warranted.
Proliferative verrucous and homogeneous Leukoplakias exhibit differential methylation patterns
Authors: Herreros‐Pomares Alejandro , Hervás David , Bagán Leticia , Proaño Alex , Bagan José 
Published: June 2024

AbstractObjectiveProliferative verrucous leukoplakia (PVL) is considered a clinically distinct entity from other oral leucoplakias (OLs) due to its clinical presentation and evolution. However, molecular differences between them remain unclear. We aimed to determine whether there are methylation differences between PVL and other forms of OLs.Materials and MethodsOral biopsies from 12 patients with PVL, eight patients with homogeneous leucoplakia (HL), and 10 healthy individuals were obtained for a genome‐wide DNA methylation analysis via the Infinium EPIC Platform.ResultsA total of 1815 differentially methylated CpGs were found between PVL and HL, with a prominent state of hypermethylation in HL patients. CpGs covered 813 genes with distinct roles, including cell adhesion, extracellular matrix organization, and cell and synaptic signaling. 43% of these genes had been previously described in cancer and associated with prognosis. We developed a multinomial logistic regression model able to differentiate HL, PVL, and control samples. The model had a cross‐validated estimate of 73% and included differentially methylated cancer‐related genes between the pathological conditions and the healthy donors, including ADNP, BRCA2, CDK13, GNB1, NIN, NUMB, PIK3C2B, PTK2, SHISA4, THSD7B, WWP1, and ZNF292. It also included CpGs covering differentially methylated genes in HL (MEN1 and TNRC6B) and PVL (ACOXL, ADH1B, CAMTA1, CBFA2T3, CPXM2, LRFN2, SORCS2, and SPN).ConclusionsPVL and HL present differential methylation patterns that could be linked to their differential clinical behavior. Our findings show the potential of methylation markers and suggest novel diagnostic biomarkers.
Efficacy of OFD with EMD for treatment of periodontal defects: A systematic review and meta‐analysis
Authors: Yang Ziyue , Yu Qin , Ren Lulu , Wang Hongyan , Zhu Lifang 
Published: June 2024

AbstractObjectivesIn order to enhance clinical improvement of periodontal defects, the addition of enamel matrix derivatives (EMD) to open flap debridement (OFD) has been investigated. The aim of this systematic review is to figure out whether such a combination, in comparison to the treatment with OFD alone has some effects on the following outcomes: clinical attachment level gain, probing depth reduction, and gingival recessions increase.MethodsElectronic databases (PubMed, Embase, Web of Science, and Cochrane) were searched for randomized controlled trials in humans addressing the use of a combination of OFD and EMD versus a control group with OFD alone for the treatment of periodontal defects, with a minimum of 6 months of follow‐up; meta‐analysis and trial sequential analysis were then performed.ResultsFrom a total of 204 records screened by title and abstract, 13 studies were read full‐text and eight out of them included in the meta‐analysis. Some significant differences have been demonstrated both for clinical attachment level gain and probing depth reduction between test and control groups.ConclusionsIn the treatment of periodontal defects, the addition of EMD to OFD seems to be beneficial in terms of clinical attachment level gain, probing depth reduction, promoting periodontal regeneration. However, such results should be considered with caution because of the small number of studies included in the meta‐analysis and their heterogeneity.
Tongue coating metabolic profiles of intra‐oral halitosis patients
Authors: Lo Kalam , Liman Aviella Nathania , Zhang Yu , Ye Wei 
Published: June 2024

AbstractObjectiveThis study focused on the metabolic characteristics of tongue coating in patients with intra‐oral halitosis (IOH) to investigate potential diagnostic biomarkers for IOH.MethodsOral healthy participants were enrolled in this study. Halitosis was evaluated with an organoleptic assessment, a Halimeter®, and an OralChroma™. Tongue coating samples were collected from 18 halitosis patients and 18 healthy controls. Liquid chromatography–mass spectrometry was conducted to reveal the IOH‐related metabolic variations in tongue coating.ResultsA total of 2214 metabolites were obtained. Most metabolites were shared between the two groups. A total of 274 upregulated metabolites, such as paramethasone acetate and indole‐3‐acetic acid, and 43 downregulated metabolites, including deoxyadenosine and valyl‐arginine, were detected in the halitosis group. Functional analysis indicated that several metabolic pathways, including arginine biosynthesis, arginine and proline metabolism, histidine metabolism, and lysine degradation were significantly enriched in the IOH group. The least absolute shrinkage and selection operator logistic regression analysis revealed that paramethasone acetate, {1‐[2‐(4‐carbamimidoyl‐benzoylamino)‐propionyl]‐piperidin‐4‐yloxy}‐acetic acid, indole‐3‐acetic acid, and valyl‐arginine were remarkably associated with IOH.ConclusionsThis study revealed the metabolites present in tongue coating and identified effective biomarkers, providing essential insights into the prediction, pathogenesis, and diagnosis of IOH.
Prevalence and associated factors of health anxiety in patients with temporomandibular disorders
Authors: Sun Wentian , Fang Shanbao , Wang Yu , Zheng Yunhao , Zhou Xueman , Yi Yating , Xiong Xin , Wang Jun 
Published: June 2024

AbstractObjectivesTo investigate the prevalence and associated factors of health anxiety (HA) in patients with Temporomandibular Disorders (TMDs) using the 8‐item Whiteley Index (WI‐8) scale.Materials and MethodsThree hundred and twenty‐nine TMDs patients completed the Visual Analog Scale (VAS), WI‐8, Jaw Functional Limitation Scale‐8 (JFLS‐8), Patient Health Questionnaire‐9 (PHQ‐9), and Generalized Anxiety Disorder‐7 (GAD‐7) scales. Clinical examinations were conducted following the Diagnostic Criteria for TMDs Axis I.ResultsThe prevalence of HA among TMDs patients was 18.54%. Patients with HA had higher scores of VAS‐current (p = 0.026), VAS‐maximum (p = 0.024), VAS‐average (p = 0.030), JFLS‐8 (p < 0.001), GAD‐7 (p < 0.001) and PHQ‐9 (p < 0.001), lower maximum mouth opening (p = 0.016), lower proportion of structure‐related TMDs (p = 0.028), and higher proportion of pain‐related TMDs (p < 0.001) compared to those without HA. The correlation coefficient was 0.61 (p < 0.001) between WI‐8 and GAD‐7 and 0.64 (p < 0.001) between WI‐8 and PHQ‐9.ConclusionApproximately one‐fifth of patients with TMDs experienced HA. HA was associated with pain perception, functional limitations, depressive, and anxiety symptoms in individuals with TMDs. HA may contribute to heightened subjective pain experiences rather than structural changes in the TMJ.
Association between Adverse Psychological Emotions and Postoperative Brace for Adolescent Idiopathic Scoliosis: A Prospective Cohort Study with Propensity Score Matching
Authors: Yang Ying , Zhang Haoran , Tian Xue , Wang Shengru , Chen Yaping , Zhang Jianguo 
Published: June 2024

ObjectiveAlthough the advantages of postoperative braces have been verified in many fields, it is not clear whether postoperative braces can help reduce patients' adverse psychological emotions such as kinesiophobia, anxiety, and depression. This study aims to analyze whether the use of a postoperative brace helps reduce adverse psychological emotions in adolescent idiopathic scoliosis (AIS) patients undergoing spinal deformity surgeries.MethodsAll consecutive patients who underwent spinal corrective surgeries at our institution between April 2023 and July 2023 formed the prospective cohort. Outcome measures were collected in the preoperative period, 3 months after surgery, and 6 months after surgery. All patients were assessed using the Tampa scale for kinesiophobia (TSK), the hospital anxiety and depression scale (HADS), and the numerical rating scale (NRS). A statistical model of propensity score matching was used to eliminate potential selection bias and maintain comparability. Multivariate linear regression models were used to determine the relationship between postoperative brace and adverse psychological emotions.ResultsAfter propensity score matching, this study ultimately enrolled 150 patients. There were no significant differences between the two groups in terms of demographic and perioperative variables. The fully adjusted model showed that the TSK scores of the non‐brace group at the 3‐month (ꞵ = 2.50, 95% CI 0.80–4.20, p = 0.005) and 6‐month follow‐up (ꞵ = 2.75, 95% CI 0.75–4.74, p = 0.007) were significantly higher than those of the brace group. The HADS score of the non‐brace group at the 3‐month follow‐up was significantly higher than that of the brace group (ꞵ = 1.75, 95% CI 0.28–3.22, p = 0.019). The NRS score of the non‐brace group at the 3‐month follow‐up was significantly higher than that of the brace group (ꞵ = 0.69, 95% CI 0.05–1.33, p = 0.034). At the 6‐month follow‐up, there were no significant difference for HADS score or NRS score between the two groups.ConclusionIn the early postoperative period, the postoperative brace could provide AIS patients with psychological supports and help them reduce the frequency of adverse psychological emotions. The postoperative brace could continuously improve the fear of movement within 6 months after surgery, and help reduce anxiety, depression, and pain within 3 months after surgery.
Is ischemic stimulus involved for J wave augmentation during coronary angiography and intracoronary administration of normal saline?
Authors: Nakayama Masafumi , Matsuo Hitoshi , Sato Takao , Okabe Masaaki , Aizawa Yoshifusa 
Published: June 2024

AbstractBackgroundJ waves may be augmented by coronary angiography (CAG) or intracoronary drug administration but the underlying mechanism is unknown.PurposeThe effect of intracoronary normal saline (NS) on J waves were investigated.Patients and methodsAfter the standard CAG using iopamidol (IopamiroR Inj), NS was injected into the right coronary artery in 10 patients with and eight patients without J waves at the baseline. The 12‐lead ECG was monitored, stored on a computer and retrieved later for measurement of the J wave amplitude before or during the coronary interventions.ResultsJ waves in leads II, III and aVF at baseline increased significantly in each lead during the right CAG and NS injection into the right coronary artery. The J wave changes were similar between the two interventions and distinct similar alterations were observed in the QRS complex.We postulated that the ischemic myocardium that was induced during CAG or intracoronary NS administration slowed the conduction velocity of depolarization in the perfusion territory and delayed the timing of J waves to appear. Then, the delayed appearance of J waves would be less opposed by electromotive force from other areas resulting in augmentation.ConclusionJ wave augmentation was observed during CAG and intracoronary NS administration. As a mechanism of augmentation, we postulated that contrast media and NS induce myocardial ischemia and delay the timing of J waves to a point of less opposition by electromotive force from other areas.Highlights
J wave augmentation has been reported during intracoronary injection of contrast media or drugs.
The present study confirmed that normal saline alone was able to augment J waves.
Mechanistically, coronary interventions using anoxic solutions can cause regional myocardial ischemia and reduce the conduction velocity of depolarization.
Then, delayed J waves are less opposed by the electromotive force from remote areas which leads to augmentation.
When a drug is diluted in normal saline and given intracoronarily, changes in J waves can be due to normal saline.
The pathophysiological and clinical significance of J waves augmented during coronary interventions need to be established.
Neighborhood Trust, Cohesion, and Diversity: How Demographic Patterns and Processes Shape Their Relationships
Authors: O'DONNELL JAMES 
Published: June 2024

AbstractCompelling evidence from around the world suggests that ethnic diversity is detrimental to neighborhood trust and cohesion. Much of this evidence derives from empirical associations found with static indicators of diversity, measuring the mix of ethnic groups at a single point in time, and controlling for a varied mix of individual and community‐level covariates. Less attention though has sought to understand how dynamic processes of migration and residential settlement both create diversity and influence trust and cohesion. In this study, census and survey data are used to analyze the demographic and economic characteristics and dynamics coinciding with diversity in local communities in Australia, and the implications for neighborhood trust and cohesion. Diverse communities are heavily concentrated in moderately and highly disadvantaged communities in large immigrant gateway cities. Highly diverse communities experience continual high levels of immigration and population turnover and contain young age structures and more diverse and transient housing and household structures. Survey analyses reveal that these characteristics substantially explain observed negative associations between diversity and neighborhood trust and cohesion. The results point to the near‐intractable difficulties in isolating the effects of diversity and the importance of understanding the dynamic demographic processes in the construction of neighborhood diversity, trust, and cohesion.
Plasma polyamines during pregnancy and their relationships with maternal allergies and the immune response of the neonates
Authors: Gázquez Antonio , García‐Serna Azahara M. , Hernández‐Caselles Trinidad , Martín‐Orozco Elena , Cantero‐Cano Esther , Prieto‐Sánchez María T. , Molina‐Ruano María D. , Castillo‐Lacalle Rafaela , Vioque Jesús , Morales Eva , García‐Marcos Luís , Larqué Elvira ,   the Nela Study Goup
Published: June 2024

AbstractBackgroundSome studies have reported that polyamine levels may influence immune system programming. The aim of this study was to evaluate the polyamine profile during gestation and its associations with maternal allergy and cytokine production in cord blood cells in response to different allergenic stimuli.MethodsPolyamines were determined in plasma of pregnant women (24 weeks, N = 674) and in umbilical cord samples (N = 353 vein and N = 160 artery) from the Mediterranean NELA birth cohort. Immune cell populations were quantified, and the production of cytokines in response to different allergic and mitogenic stimuli was assessed in cord blood.ResultsSpermidine and spermine were the most prevalent polyamines in maternal, cord venous, and cord arterial plasma. Maternal allergies, especially allergic conjunctivitis, were associated with lower spermine in umbilical cord vein. Higher levels of polyamines were associated with higher lymphocyte number but lower Th2‐related cells in cord venous blood. Those subjects with higher levels of circulating polyamines in cord showed lower production of inflammatory cytokines, especially IFN‐α, and lower production of Th2‐related cytokines, mainly IL‐4 and IL‐5. The effects of polyamines on Th1‐related cytokines production were uncertain.ConclusionsSpermidine and spermine are the predominant polyamines in plasma of pregnant women at mid‐pregnancy and also in umbilical cord. Maternal allergic diseases like allergic conjunctivitis are related to lower levels of polyamines in cord vein, which could influence the immune response of the newborn. Cord polyamine content is related to a decreased Th2 response and inflammatory cytokines production, which might be important to reduce an allergenic phenotype in the neonate.