bluuebunny/crossref_metadata_2025_split huggingface dataset:
On the Ethical Priority of Problem Solving in Case‐Based Teacher Ethics: Grounding an Anti‐Oppressive Approach
Authors: Tanchuk Nicolas , Emery Alyssa 
Published: June 2024

AbstractA central problem for phronetic case‐based approaches to the ethics of teaching lies in the proper determination of normative ethical problems. Judgments about the character of normative ethical problems depend in part on background beliefs about what is (or is not) of ethical value. Thus, to distinguish genuinely normative ethical problems, teachers seem to first require knowledge of what is of ethical value, which practical problems themselves cannot generate. To resolve this practical and theoretical problem, Nicolas Tanchuk and Alyssa Emery argue for a Deweyan approach to teacher ethics that asserts two central theses: First, negatively, that inductive evidence warrants skepticism about any normative theory grounded in external reasons — (purported) reasons that are actually or possibly disconnected from an agent's motivational set of beliefs, desires, and dispositions. Second, that a cognitive and affective orientation toward solving problems through learning survives skepticism about external ethical reasons, grounding the commitments of many anti‐oppressive teacher educators.
Time‐dependent cost comparison and health economic impact analysis of second‐line interventions for transplant‐ineligible patients with relapsed or refractory diffuse large B cell lymphoma
Authors: Kurte Melina Sophie , Siefen Ann‐Cathrine , Jakobs Florian , Poos Tabea , von Tresckow Julia , von Tresckow Bastian , Reinhardt Hans Christian , Kron Florian 
Published: June 2024

AbstractObjectivesNovel interventions (axicabtagene ciloleucel [axi‐cel], lisocabtagene maraleucel [liso‐cel], tafasitamab‐lenalidomide [Tafa‐L], polatuzumab‐rituximab‐bendamustine [pola‐BR]) improve clinical outcomes in second‐line (2 L) treatment of transplant‐ineligible patients with early relapse or refractory (R/R) diffuse large B cell lymphoma (DLBCL). The costs vary depending on the respective treatment regimen and the treatment duration, difficult comparability in reimbursement decisions. The objective was to analyze the health economic impacts of novel 2 L interventions and conventional immunochemotherapies (bendamustine‐rituximab [BR], rituximab‐gemcitabine‐oxaliplatin [R‐GemOx]) from a German healthcare payer's perspective as a function of treatment duration.MethodsAn economic model was developed to compare treatment costs of 2 L interventions depending on the treatment duration. Treatment duration was measured by progression‐free survival (PFS), identified based on a systematic review. Total and average costs were calculated over 5 years to evaluate incremental costs at median PFS for each intervention.ResultsAverage costs per month at median PFS ranged from €2846 (95% CI: 5067‐1641) to €40 535 (95% CI: 91180‐N/A) for BR and liso‐cel, respectively. Incremental costs at the lowest median PFS (R‐GemOx: 5.3 months) revealed −€664, €5560, €11 817, €53 145, and €67 745 for BR, Tafa‐L, pola‐BR, axi‐cel, and liso‐cel as compared to R‐GemOx, respectively.ConclusionsAnalyses uncovered a variation of incremental costs of 2 L transplant‐ineligible DLBCL interventions as a function of time leading to amortization of high‐priced interventions.
Brain network topological changes in inflammatory bowel disease: an exploratory study
Authors: Polverino Arianna , Troisi Lopez Emahnuel , Minino Roberta , Romano Antonella , Miranda Agnese , Facchiano Angela , Cipriano Lorenzo , Sorrentino Pierpaolo 
Published: June 2024

AbstractAlthough the aetio‐pathogenesis of inflammatory bowel diseases (IBD) is not entirely clear, the interaction between genetic and adverse environmental factors may induce an intestinal dysbiosis, resulting in chronic inflammation having effects on the large‐scale brain network. Here, we hypothesized inflammation‐related changes in brain topology of IBD patients, regardless of the clinical form [ulcerative colitis (UC) or Crohn's disease (CD)]. To test this hypothesis, we analysed source‐reconstructed magnetoencephalography (MEG) signals in 25 IBD patients (15 males, 10 females; mean age ± SD, 42.28 ± 13.15; mean education ± SD, 14.36 ± 3.58) and 28 healthy controls (HC) (16 males, 12 females; mean age ± SD, 45.18 ± 12.26; mean education ± SD, 16.25 ± 2.59), evaluating the brain topology. The betweenness centrality (BC) of the left hippocampus was higher in patients as compared with controls, in the gamma frequency band. It indicates how much a brain region is involved in the flow of information through the brain network. Furthermore, the comparison among UC, CD and HC showed statistically significant differences between UC and HC and between CD and HC, but not between the two clinical forms. Our results demonstrated that these topological changes were not dependent on the specific clinical form, but due to the inflammatory process itself. Broader future studies involving panels of inflammatory factors and metabolomic analyses on biological samples could help to monitor the brain involvement in IBD and to clarify the clinical impact.
Depletion of SASP senescent cardiomyocytes with senolytic drugs confers therapeutic effects in doxorubicin‐related cardiotoxicity
Authors: Xia Wenzheng , Chen Hanbin , Yang Han , Zhu Liaoxiang , Xie Congying , Hou Meng 
Published: June 2024

Doxorubicin (Dox), an anthracycline antibiotic, is widely used in cancer treatment. Although its antitumor efficacy appears significant, its clinical use is greatly restricted by its induction of cardiotoxicity. Cardiac senescence drives the Dox‐induced cardiotoxicity, but whether diminishing these senescent cardiomyocytes could alleviate the cardiotoxicity remains unclear. Here, we assessed whether senescent cardiomyocytes have a senescence‐associated secretory phenotype (SASP) that affects healthy non‐senescent cardiomyocytes, rendering them senescent via the delivery of exosomes. Additionally, we explored whether targeting SASP senescent cardiomyocytes using a Bcl‐2 inhibitor could alleviate cardiotoxicity. Cardiac damage was induced in a mouse model of continuous Dox treatment in vivo, and cardiomyocytes in vitro. Immunofluorescence of the senescence markers of Cdkn2a, Cdkn1a and γ‐H2A.X was used to assess the SASP in the Dox‐treated heart. To explore the molecular mechanisms involved, the Bcl‐2 inhibitor ABT‐199 was employed to eliminate SASP senescent cardiomyocytes. We show that the cardiomyocytes acquire a SASP during Dox treatment. The senescent cardiomyocytes upregulated Bcl‐2, although treatment of mice with ABT‐199 selectively eliminated SASP senescent cardiomyocytes involved in Dox‐induced cardiotoxicity, thus leading to partial alleviation of Dox‐induced cardiotoxicity. Moreover, we concluded that SASP factors secreted by senescent cardiomyocytes induced by Dox renders otherwise healthy cardiomyocytes senescent through exosome delivery. Our findings suggest that SASP senescent cardiomyocytes are a significant component of the pathogenesis of Dox‐dependent cardiotoxicity and indicate that targeting the clearance of SASP senescent cardiomyocytes could be a new therapeutic approach for Dox‐induced cardiac injury.
VALIDATING HISTORICAL INTERPRETATIONS: AN APPROACH FROM CULTURAL ANTHROPOLOGY
Authors: ROSEN LAWRENCE 
Published: June 2024

ABSTRACTHistorians and anthropologists share a common problem of setting criteria for the validation of their interpretations. While many features are shared and explicit—for example, that a full range of data needs to be considered and that information should be reliably sourced—the actual criteria for assessing supportable interpretations are frequently left unexamined. Following consideration of schemes that have been put forth for validating interpretation in literature, this article considers the criteria applied to the history of an Indonesian town and those employed when scholars have revisited the site of a predecessor's research. Because no interpretation is without some theoretical backdrop, this article considers a particular theory of culture that may facilitate the refinement of standards. The criteria that are then suggested—conjuncture, scope, intersection, comparability, and self‐accounting—may help to pinpoint not uniquely correct interpretations but better or worse ones. To test these criteria, this article briefly analyzes two case studies of both historical and anthropological concern: one relates to the history and organization of tribal‐based polities and the other concerns the dispute over the circumstances surrounding the death of Captain James Cook. The article concludes that reinvigorating a conversation about such criteria can reinforce the shared interests of historians and anthropologists that have proven so fruitful to recent scholarship.
Flowering areas enhance insect pollinators and biological control agents in wheat intensive agro‐ecosystems
Authors: Magagnoli Serena , Bosi Sara , Negri Lorenzo , Dinelli Giovanni , Burgio Giovanni , Masetti Antonio 
Published: June 2024

Abstract
This 4‐year study (2018–2021) aimed at investigating the effects of flowering areas inserted at the margin of soft wheat fields (Triticum aestivum L.) in comparison with spontaneous field margins. The action formed part of a multidisciplinary initiative promoted by the Barilla food company, aimed at promoting the sustainable production of soft wheat.
Specific aims were to study the effects of flowering areas on (i) the abundance and species richness of insect pollinators, including wild bees, syrphids and butterflies; (ii) the levels of wheat aphid and bug infestations and (iii) the assemblages of biological control agents of aphids (coccinellids and aphid mummies as a result of parasitization).
Insect surveys were carried out on 61 wheat‐growing farms located in Northern Italy. Insect pollinators were sampled on all farms, whereas wheat aphids, wheat bugs and aphid biological control agents were investigated in a sub‐sample of 20 farms.
Results generally indicated a positive impact of flowering areas on multiple taxa in comparison with spontaneous field margins. The abundance of pollinators and coccinellids was significantly enhanced by the flowering areas. Aphid mummies showed an interaction between strategies and distances with more mummies at 5 m in wheat plots close to flowering areas and at 50 m in the plots close to spontaneous field margin (control).
Flowering areas were validated as an important tool for promoting beneficial taxa in agro‐ecosystems. However, the successful establishment of this ecological infrastructure was suggested to rely on several factors, which included both the selection of suitable flowering plant species and the implementation of appropriate management practices.
Treatment of sebaceous carcinoma with Mohs micrographic surgery versus wide local excision: a systematic review
Authors: Yadlapati Sujitha , Rosa‐Nieves Priscilla M. , Mehta Nina , Merritt Bradley G. , Carrasquillo Osward Y. 
Published: June 2024

AbstractSebaceous carcinoma (SC) is a rare neoplasm affecting periocular and extraocular sites. If inadequately treated, it can recur and cause morbidity. Specific management guidelines have not been established. Wide local excision (WLE) has been traditionally used; however, Mohs micrographic surgery (MMS) can be advantageous because of complete margin assessment and tissue‐sparing nature. This analysis aims to systematically review the surgical modalities used for the management of SC. Articles meeting eligibility criteria were identified using MEDLINE (via PubMed), Embase, Cochrane, and Scopus databases. All studies investigating surgical management of SC with WLE or MMS were considered. Seventy studies met inclusion criteria, including retrospective cohort studies, case series, and case reports. WLE was used in 32 studies, MMS in 29, and MMS and WLE in 9. Subgroup analysis showed that MMS has lower recurrence rates. For WLE, local, regional, and distant recurrence rates were 23.4%, 13.3%, and 11.0%, respectively, and for MMS, 6.8%, 4.3%, and 4.6%, respectively. Patients treated with WLE were more likely to have local recurrence than patients treated with MMS (P = 0.001). WLE cases were more likely to have a regional (P = 0.05) and distant recurrence (P = 0.001). Limitations of the study include heterogeneity of case reports, case series, and retrospective studies, variable follow‐up times between the two groups, and large tumors included in the WLE category. In addition, disease‐specific survival was not evaluated. MMS cases showed a superior outcome for local, regional, and distant recurrence, making it a good option for the management of SC.
Own or public? Later livelihoods of Ukrainian war migrant households in Poland
Authors: Kochaniak Katarzyna , Korzeniowska Anna M. , Pietrzak Michał Bernard 
Published: June 2024

AbstractThis paper presents empirical research on the livelihood resources of Ukrainian households that fled to Poland due to the Russian invasion and reside there long term. Using a nationwide sample of these households and an accurate econometric framework, we investigate the factors influencing the role of income from work, other private resources and public assistance in covering their living costs in exile. Our findings confirm the importance of public assistance addressed to professional activation and childcare for households' self‐reliance. Assistance from employers, housing conditions, intentions to settle permanently in Poland and financial responsibility for relatives in Ukraine are also among the decisive factors. However, sufficient monetary aid hinders households' self‐reliance, along with health problems, language barriers and a lack of professional qualifications. Household composition is also significant, as those with children face the most adverse outcomes. Based on our results, we provide recommendations for public authorities responsible for migration policy.
Evo‐devo in the ophiuroid family Ophiocomidae
Authors: Byrne Maria , Cisternas Paula , O'Hara Timothy , Selvakumaraswamy Paulina 
Published: June 2024

AbstractThe Ophiuroidea, the most diverse echinoderm class, exhibits an array of life history patterns and larval forms, the evolution of which is poorly understood. With a robust phylogeny available for the major family, the Ophiocomidae, we undertook an assessment of the evolution of development in these ophiuroids. We spawned 15 species and documented larval development in 14 of these. In total, data on egg size or larval development were available for 27 species across the four recognized genera (Breviturma, Ophiocoma, Ophiocomella, and Ophiomastix). Ophiocomids have a bimodal egg size distribution. Species with small eggs (x̄ = 82 μm diameter, range 55–100 μm diameter) and large eggs (x̄ = 424 μm diameter, range 335–550 μm diameter) have planktotrophic ophioplutei and lecithotrophic vitellariae, respectively. The advanced ophiopluteus transforms into an armless vitellaria prior to metamorphosis through resorption of the larval arms and rearrangement of the ciliary tracts into series of transverse bands. Thus, the Type II pattern of development (which includes both the ophiopluteus and vitellaria) may be characteristic of the Ophiocomidae. This is not seen in other ophiuroid families. Evolution of nonfeeding (lecithotrophic) development through a vitellaria larva appears to have occurred only once in this family, in the genus Ophiomastix. Several traits appear to be specific to some species or genera, including an ornate fertilization envelope (Ophiocoma species), the presence of an early barrel‐shaped larva (Breviturma species), and the presence of vibratile lobes in advanced ophioplutei (Breviturma, Ophiocomella). In species with lecithotrophic development, the vitellaria is distinct, with prominent ciliated lobes around the developing juvenile rudiment. Larval form may assist with identification of ophiocomid larvae in plankton samples.
Overexpression of olfactory receptor 78 ameliorates brain injury in cerebral ischaemia–reperfusion rats by activating Prkaca‐mediated cAMP/PKA‐MAPK pathway
Authors: Kang Tao , Zhu Lijuan , Xue Yanli , Yang Qian , Lei Qi , Wang Qianqian 
Published: June 2024

AbstractIschemic stroke is one of the main causes of disability and death. However, recanalization of occluded cerebral arteries is effective only within a very narrow time window. Therefore, it is particularly important to find neuroprotective biological targets for cerebral artery recanalization. Here, gene expression profiles of datasets GSE160500 and GSE97537 were downloaded from the GEO database, which were related to ischemic stroke in rats. Olfactory receptor 78 (Olfr78) was screened, and which highly associated with Calcium signalling pathway and MAPK pathway. Interacting protein of Olfr78, Prkaca, was predicted by STRING, and their interaction was validated by Co‐IP analysis. Then, a rat model of middle cerebral artery occlusion/reperfusion (MCAO/R) and a neuronal cell model stimulated by oxygen–glucose deprivation/reoxygenation (OGD/R) were constructed, and the results showed that expression of Olfr78 and Prkaca was downregulated in MCAO rats and OGD/R‐stimulated neurons. Overexpression of Olfr78 or Prkaca inhibited the secretion of inflammatory factors, Ca2+ overload, and OGD/R‐induced neuronal apoptosis. Moreover, Overexpression of Prkaca increased protein levels of cAMP, PKA and phosphorylated p38 in OGD/R‐stimulated neurons, while SB203580, a p38 inhibitor, treatment inhibited activation of the cAMP/PKA‐MAPK pathway and counteracted the effect of Olfr78 overexpression on improvement of neuronal functions. Meanwhile, overexpression of Olfr78 or Prkaca markedly inhibited neuronal apoptosis and improved brain injury in MCAO/R rats. In conclusion, overexpression of Olfr78 inhibited Ca2+ overload and reduced neuronal apoptosis in MCAO/R rats by promoting Prkaca‐mediated activation of the cAMP/PKA‐MAPK pathway, thereby improving brain injury in cerebral ischaemia–reperfusion.
Troponin T1 in tumorigenesis and immune modulation: Insights into multiple cancers and kidney renal clear cell carcinoma
Authors: Zhang Qianjin , Hao Lin , Wang Fengye , Yu Quansheng , Wu Shaoyuan , Han Conghui 
Published: June 2024

AbstractTroponin T1 (TNNT1) plays a crucial role in muscle contraction but its role in cancer, particularly in kidney renal clear cell carcinoma (KIRC), is not well‐understood. This study explores the expression, clinical significance and biological functions of TNNT1 in various cancers, with an emphasis on its involvement in KIRC. We analysed TNNT1 expression in cancers using databases like TCGA and GTEx, assessing its prognostic value, mutation patterns, methylation status and functional implications. The study also examined TNNT1's effect on the tumour microenvironment and drug sensitivity in KIRC, complemented by in vitro TNNT1 knockdown experiments in KIRC cells. TNNT1 is overexpressed in several cancers and linked to adverse outcomes, showing frequent upregulation mutations and abnormal methylation. Functionally, TNNT1 connects to muscle and cancer pathways, affects immune infiltration and drug responses, and its overexpression in KIRC is associated with advanced disease and reduced survival. Knocking down TNNT1 curbed KIRC cell growth. TNNT1's aberrant expression plays a significant role in tumorigenesis and immune modulation, highlighting its value as a prognostic biomarker and a potential therapeutic target in KIRC and other cancers. Further studies are essential to understand TNNT1's oncogenic mechanisms in KIRC.
How Do Crises Affect Policy Subsystems? The Evolution of Policy Core Beliefs in the EU Asylum Policy
Authors: Mastroianni Laura 
Published: June 2024

AbstractCrises, shocks, and perturbations are frequently considered turning points in public policy literature. The Advocacy Coalition Framework has become one of the most employed policy process frameworks, focusing on policy subsystems, belief systems and shocks as one of the drivers of policy change. Relying on a network approach, this article aims at analysing the EU asylum policy by exploring the prioritisation of policy core beliefs before, during and after the so‐called refugee crisis. From a methodological perspective, discourse network analysis (DNA) is employed. The results show that the system of policy core beliefs has not stabilised in the aftermath of the crisis, implying a ‘conservative’ crisis response approach and short‐term effects on the policy subsystem. The innovation of this article stands on the theoretical–analytical elaborations of some crisis management and public policy literature core concepts and the empirical testing of said concepts through an original dataset with DNA.
Attraction of microarthropods to dung of invasive mammals in meadows of northwestern Patagonia
Authors: Kun Marcelo E. , Galende Gladys I. 
Published: June 2024

AbstractThe attractive effect of dung on coprophagous beetle communities and their role in dung degradation are well‐known phenomena. However, little research has been conducted on the recruitment capacity of this substrate for other arthropods, especially those inhabiting the soil. With the aim of beginning to recognize general patterns in these relationships, the influence of the structure and origin of dung from invasive exotic mammals on the recruitment of microarthropods was investigated in two meadows within Nahuel Huapi National Park in southwestern Argentina. Abundance, richness and diversity of microarthropod communities collected on invasive mammal dung were studied. A total of 2478 microarthropods were collected and 52 species were identified. Recruitment of microarthropods on dung of two invasive coprophagic herbivores, the rabbit,Oryctolagus cuniculusand the hare,Lepus europaeus, were compared with two invasive non‐coprophagic mammals, one herbivorous, the red deer,Cervus elaphusand one omnivorous, the wild boar,Sus scrofa. Pellets ofS. scrofashowed the highest microarthropod abundance and richness while diversity was greatest on pellets ofC. elaphus. Pygmephorid and oribatid mites and springtails were the most abundant.Liposcelispsocopterans and oribatid mites were more abundant onS. scrofadung. Low similarity was observed when comparing dung of invasive mammals from different sites revealing spatial variability regarding species composition. Based on its more diverse diet, we conclude thatS. scrofadung exerts a strong influence on microarthropod communities by recruiting a greater number of individuals and species than the dung of the remaining invasive mammals.