bluuebunny/crossref_metadata_2025_split huggingface dataset:
Bupropion versus methylphenidate in the treatment of children with attention‐deficit/hyperactivity disorder: randomized double‐blind study
Authors: Jafarinia Morteza , Mohammadi Mohammad‐Reza , Modabbernia Amirhossein , Ashrafi Mandana , Khajavi Danial , Tabrizi Mina , Yadegari Noorollah , Akhondzadeh Shahin 
Published: July 2012

ObjectiveTo compare the safety and efficacy of bupropion with methylphenidate in children and adolescents with attention‐deficit/hyperactivity disorder (ADHD).MethodsIn a 6‐week randomized double‐blind study, 44 patients with a DSM‐IV‐TR diagnosis of ADHD were randomly assigned to receive bupropion 100–150 mg/day (100 mg/day for <30 kg and 150 mg/day for >30 kg) or methylphenidate 20–30 mg/day. Symptoms were assessed using Teacher and Parent Attention‐Deficit/Hyperactivity Disorder Rating Scale‐IV (ADHD‐RS‐IV) at baseline and weeks 3 and 6.ResultsForty patients had at least one post‐baseline measurement, and 38 patients completed the trial. No significant difference was found between the two groups on the Parent and Teacher ADHD‐RS‐IV scores ([F(1, 38) = 0.266, p = 0.609] and [F(1, 38) = 0.001, p = 0.972], respectively). By week 6, 18 patients (90%) in each group achieved response on the Parent scale (Fisher's exact test p‐value = 1.0). With the Teacher ADHD‐RS‐IV used, eight (40%) patients in the bupropion group and 12 (60%) patients in the methylphenidate group achieved response by week 6 (χ2(1) = 1.600, p = 0.206). Headache was observed more frequently in the methylphenidate group. Frequency of other side effects was not significantly different between the two groups.ConclusionsBupropion has a comparable safety and efficacy profile with methylphenidate in children and adolescents with ADHD. Copyright © 2012 John Wiley & Sons, Ltd.
The naringenin‐induced proapoptotic effect in breast cancer cell lines holds out against a high bisphenol a background
Authors: Bulzomi Pamela , Bolli Alessandro , Galluzzo Paola , Acconcia Filippo , Ascenzi Paolo , Marino Maria 
Published: July 2012

AbstractFruit and vegetable consumption has generally been associated with the prevention or suppression of cancer. However, food could contain a multitude of chemicals (e.g., bisphenol A; BPA) that could synergize or antagonize the effects of diet‐derived compounds. Remarkably, food containers (e.g., water and infant bottles) are the largest source of exposure to BPA for human beings. Here, the effects of the coexposure of naringenin (Nar, 1.0 × 10−9 M to 1.0 × 10−4 M) and BPA (1.0 × 10−5 M) in estrogen‐dependent breast cancer cell lines expressing (i.e., MCF‐7 and T47D) or not expressing (i.e., MDA‐MB‐231) estrogen receptor α (ERα) are reported. Although both Nar and BPA bind to ERα, they induce opposite effects on breast cancer cell growth. BPA induces cell proliferation, whereas Nar only decreases the number of ERα‐positive cells (i.e., MCF‐7 and T47D). Notably, even in the presence of BPA, Nar impairs breast cancer cell proliferation by activating caspase‐3. The molecular pathways involved require p38 activation, whereas, the BPA‐induced AKT activation is completely prevented by the Nar treatment. As a whole, Nar maintains its proapoptotic effects even in the presence of the food contaminant BPA, thus, enlarging the chemopreventive potential of this flavanone. © 2012 IUBMB IUBMB Life, 64(8): 690–696, 2012
Towards automated segmentation of cells and cell nuclei in nonlinear optical microscopy
Authors: Medyukhina Anna , Meyer Tobias , Schmitt Michael , Romeike Bernd F. M. , Dietzek Benjamin , Popp Jürgen 
Published: July 2012

AbstractNonlinear optical (NLO) imaging techniques based e.g. on coherent anti‐Stokes Raman scattering (CARS) or two photon excited fluorescence (TPEF) show great potential for biomedical imaging. In order to facilitate the diagnostic process based on NLO imaging, there is need for an automated calculation of quantitative values such as cell density, nucleus‐to‐cytoplasm ratio, average nuclear size. Extraction of these parameters is helpful for the histological assessment in general and specifically e.g. for the determination of tumor grades. This requires an accurate image segmentation and detection of locations and boundaries of cells and nuclei. Here we present an image processing approach for the detection of nuclei and cells in co‐registered TPEF and CARS images. The algorithm developed utilizes the gray‐scale information for the detection of the nuclei locations and the gradient information for the delineation of the nuclear and cellular boundaries. The approach reported is capable for an automated segmentation of cells and nuclei in multimodal TPEF‐CARS images of human brain tumor samples. The results are important for the development of NLO microscopy into a clinically relevant diagnostic tool. (© 2012 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Potential bioactivity of coatings formed on AZ91D magnesium alloy by plasma electrolytic anodizing
Authors: Vu Thanh‐Nam , Veys‐Renaux Delphine , Rocca Emmanuel 
Published: July 2012

AbstractMagnesium is a potential candidate as biodegradable orthopedic implant thanks to its remarkable mechanical properties closed to those of natural bone. But its low corrosion resistance in the body fluid is a limiting factor. By using electrolytic plasma (or microarc) anodizing process, 10–20 μm protective coatings were formed on AZ91D magnesium alloys at a constant current density of 20 mA cm−2. The effect of a small addition of CaO (1–3 g L−1) to a classical electrolytic bath (made of KOH 3 mol L−1, KF 0.5 mol L−1, and K2HPO4 1 mol L−1) was studied. The anodic films, investigated by X‐ray diffraction and scanning electron microscope–energy dispersive spectroscopy, show a porous structure containing crystallized Mg(OH)2, MgO, MgAl2O4, as well as Ca and P elements. The 1 g L−1 CaO‐containing electrolyte leads to morphology and composition permitting optimum corrosion behavior evaluated by stationary electrochemical measurements and impedance spectroscopy. This improvement is associated with both the appearing of a “sealing” layer and the precipitation of an outermost Ca/P‐containing layer (hydroxyapatite like) in simulated body fluid. The control of the corrosion behavior of coated magnesium alloys is therefore required to enhance their potential bioactivity. © 2012 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2012.
Co‐Occurring Anger in Young People With Asperger's Syndrome
Authors: Quek Lake‐Hui , Sofronoff Kate , Sheffield Jeanie , White Angela , Kelly Adrian 
Published: July 2012

ObjectivesThe co‐occurrence of anger in young people with Asperger's syndrome (AS) has received little attention despite aggression, agitation, and tantrums frequently being identified as issues of concern in this population. The present study investigated the occurrence of anger in young people with AS and explores its relationship with anxiety and depression.MethodSixty‐two young people (12–23 years old) diagnosed with AS were assessed using the Beck Anger Inventory for Youth, Spence Children's Anxiety Scale, and Reynolds Adolescent Depression Scale.ResultsAmong young people with AS who participated in this study, 41% of participants reported clinically significant levels of anger (17%), anxiety (25.8%) and/or depression (11.5%). Anger, anxiety, and depression were positively correlated with each other. Depression, however, was the only significant predictor of anger.ConclusionAnger is commonly experienced by young people with AS and is correlated with anxiety and depression. These findings suggest that the emotional and behavioral presentation of anger could serve as a cue for further assessment, and facilitate earlier identification and intervention for anger, as well as other mental health problems.
Study of iron sources and hydrogen peroxide supply in the photo‐Fenton process using acetaminophen as model contaminant
Authors: Carra Irene , Malato Sixto , Santos‐Juanes Lucas , Casas López José Luis , Sánchez Pérez José Antonio 
Published: July 2012

AbstractBACKGROUND: The aim of this study was the evaluation of iron (II) D‐gluconate and iron (II) sulfate as iron sources for the photo‐Fenton process at initial neutral pH. Acetaminophen was used as the contaminant for this purpose. The evaluation was carried out at laboratory and pilot‐plant scales. In addition, hydrogen peroxide dosage was analyzed in order to decrease reactant consumption.RESULTS: 20 mg Fe L−1 was added as iron salt or iron D‐gluconate; hydrogen peroxide dosage proved to be efficient when using iron sulfate, obtaining similar mineralization levels for one large H2O2 addition, two smaller additions and continuous dosage (78%, 74% and 78% mineralization, respectively). However, when D‐gluconate was used, H2O2 dosage resulted in a slower process rate: 74% mineralization for one large H2O2 addition versus 49% mineralization for two smaller additions.CONCLUSIONS: Results showed that iron complexes could form between iron and degradation by‐products increasing reaction efficiency. The ratio between the dissolved organic carbon concentrations of the contaminant and the iron complex proved to be important as well. H2O2 dosage confirmed that two reactant additions led to the best results, which was then corroborated with real wastewater. © 2012 Society of Chemical Industry
Expression and localization of translationally controlled tumor protein in rat urinary organs
Authors: Sheverdin Vadim , Bae Seong‐Yeon , Shin Dong Hae , Lee Kyunglim 
Published: July 2012

AbstractThis study describes the very first assessment of the expression and localization of translationally controlled tumor protein (TCTP) in adult rat urinary organs. TCTP expression levels in kidneys, urinary bladder, and urethra were evaluated by sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS–PAGE) and Western blotting, and its cellular localization was examined immunohistochemically in paraffin sections of various urinary organs. TCTP was found in all urinary organs. Its expression was high in the urethra and low in the bladder. TCTP was localized in glomerular podocytes, epithelium of proximal and distal renal tubules, in the loop of Henle, and in the transitional epithelium of the bladder and urethra, mostly in basal cell layers). The subcellular localization of TCTP in these urinary organs was cytoplasmic. These findings suggest that TCTP may be involved in urine formation and excretion. Microsc. Res. Tech. 2012. © 2012 Wiley Periodicals, Inc.
Non‐contrast enhanced MR angiography: Physical principles
Authors: Wheaton Andrew J. , Miyazaki Mitsue 
Published: July 2012

AbstractNoncontrast‐enhanced magnetic resonance angiography (NCE‐MRA) methods have been demonstrated in anatomies throughout the body. Previously established NCE‐MRA techniques suffered from long scan times or low sensitivity. Advances in hardware and software have made NCE‐MRA scan times clinically feasible. Recent concerns over the safety of gadolinium‐based contrast material combined with the expense of the material and its administration have generated a demand for NCE‐MRA. In response, several new NCE‐MRA methods have been developed. The physical mechanisms underlying five general classes of NCE‐MRA methods (inflow effect, flow‐dependency on cardiac phase, flow‐encoding, spin labeling, and relaxation) are explained. The original techniques of time‐of‐flight (TOF) and phase contrast MRA (PC‐MRA) are briefly introduced. New developments in NCE‐MRA, including hybrid of opposite‐contrast (HOP‐MRA), four dimensional PC‐MRA (4D Flow), cardiac‐gated 3D fast‐spin‐echo, flow‐sensitive dephasing (FSD), arterial spin labeling (ASL), and balanced steady‐state free‐precession (bSSFP) are highlighted. The primary applications, advantages, and limitations of established and emerging NCE‐MRA techniques are discussed. J. Magn. Reson. Imaging 2012;36:286–304. © 2012 Wiley Periodicals, Inc.
ERK activation and expression of neuronal cell cycle markers in the hippocampus after entorhinal cortex lesion
Authors: Hernández‐Ortega Karina , Arias Clorinda 
Published: July 2012

AbstractCurrent findings suggest that neuronal cell death is frequently associated with the aberrant expression of cell cycle‐regulatory proteins in postmitotic neurons. Aberrant cell cycle reentry has been implicated in diverse neurodegenerative conditions, including Alzheimer's disease (AD). Previously we reported that the appearance of cell cycle markers in postmitotic neurons of the entorhinal cortex (EC) after excitotoxic hippocampal damage is associated with the expression of phospho‐tau and amyloid precursor protein (APP). However, the question of the signaling pathway involved in this cell cycle reentry remains unresolved. Differentiated neurons use the molecular mechanisms initially acquired to direct cell proliferation, such as the Ras–extracellular signal‐regulated kinase (ERK1/2) pathway, to regulate synaptic plasticity. In this work we explored whether ERK1/2‐related signaling might contribute to the cell cycle reentry in hippocampal neurons after a unilateral EC lesion. We showed that, within the first 24 hr after hippocampal deafferentation, numerous neurons expressed phospho‐ERK1/2, concomitantly with the gradual increases in cyclin D1 and cyclin B immunoreactivity in the dentate gyrus and hilus. Several of these immunopositive cells to phospho‐ERK1/2 and cyclin B in hippocampus are postmitotic neurons, insofar as they are positive to NeuN. The intracisternal administration of U0126 (an MEK inhibitor), previous to the excitotoxic lesion, decreased the activation of ERK1/2 and the expression of cyclin D1 and cyclin B in the hippocampus. The present findings support the notion that ERK1/2 plays a role in cell cycle reactivation in mature neurons efferently connected to the lesion site. © 2012 Wiley Periodicals, Inc.
Mass transfer characteristics during convective, microwave and combined microwave–convective drying of lemon slices
Authors: Sadeghi Morteza , Mirzabeigi Kesbi Omid , Mireei Seyed Ahmad 
Published: July 2012

AbstractBACKGROUND: The investigation of drying kinetics and mass transfer phenomena is important for selecting optimum operating conditions, and obtaining a high quality dried product. Two analytical models, conventional solution of the diffusion equation and the Dincer and Dost model, were used to investigate mass transfer characteristics during combined microwave‐convective drying of lemon slices. Air temperatures of 50, 55 and 60 °C, and specific microwave powers of 0.97 and 2.04 W g−1 were the process variables.RESULTS: Kinetics curves for drying indicated one constant rate period followed by one falling rate period in convective and microwave drying methods, and only one falling rate period with the exception of a very short accelerating period at the beginning of microwave‐convective treatments. Applying the conventional method, the effective moisture diffusivity varied from 2.4 × 10−11 to 1.2 × 10−9 m2 s−1. The Biot number, the moisture transfer coefficient, and the moisture diffusivity, respectively in the ranges of 0.2 to 3.0 (indicating simultaneous internal and external mass transfer control), 3.7 × 10−8 to 4.3 × 10−6 m s−1, and 2.2 × 10−10 to 4.2 × 10−9 m2 s−1 were also determined using the Dincer and Dost model.CONCLUSIONS: The higher degree of prediction accuracy was achieved by using the Dincer and Dost model for all treatments. Therefore, this model could be applied as an effective tool for predicting mass transfer characteristics during the drying of lemon slices. © 2012 Society of Chemical Industry
The probiotic Lactobacillus rhamnosus BFE5264 and Lactobacillus plantarum NR74 promote cholesterol efflux and suppress inflammation in THP‐1 cells
Authors: Yoon Hong‐sup , Ju Jae‐hyun , Lee Ji‐eun , Park Hyun‐joon , Lee Jung‐min , Shin Hyeun‐kil , Holzapfel Wilhelm , Park Kun‐young , Do Myoung‐Sool 
Published: July 2012

AbstractBACKGROUND: The balance between the rate of cholesterol uptake/accumulation and the rate of cholesterol efflux is reflected in the amount of lipid accumulation in macrophages. Based upon the fact that liver X receptors (LXRs) play a role in cholesterol efflux, we studied the effects of probiotics on cholesterol efflux and anti‐inflammatory action in macrophages. We confirmed changes in LXR expression by treatment of LXR‐transfected CHO‐K1 cells with lactic acid bacteria (LAB), and co‐cultured THP‐1 cells with LAB to investigate changes in cholesterol efflux and inflammation.RESULTS: The experiment with CHO‐K1 cells showed upregulation of LXR‐β by LAB. Treatment of THP‐1 cells with LAB promoted LXR expression in THP‐1, which eventually led to significant upregulation of ABCA1 and ABCG1 expression. The treatment with live LAB also significantly promoted cholesterol efflux. LAB suppressed expression of interleukin (IL)‐1β and tumor necrosis factor (TNF)‐α, which resulted from activation of LXR.CONCLUSION: Our study shows that Lactobacillus rhamnosus BFE5264 and Lactobacillus plantarum NR74 activated LXR and induced cholesterol efflux by promoting expression of ABCA1 and ABCG1. Both strains also suppressed proinflammatory cytokines including IL‐1β and TNF‐α. This study could account for the observation that LAB may block foam cell formation by cholesterol efflux and immune modulation. © 2012 Society of Chemical Industry
Microfluidics as A Tool to Understand the Build‐Up Mechanism of Exponential‐Like Growing Films
Authors: Madaboosi Narayanan , Uhlig Katja , Jäger Magnus S. , Möhwald Helmuth , Duschl Claus , Volodkin Dmitry V. 
Published: July 2012

AbstractMicrofluidics is used here for the first time to efficiently tune the growth conditions for understanding the build‐up mechanism of exponentially growing polyelectrolyte (PE) films. The velocity of PE supply and time of interaction can be successfully altered during the layer‐by‐layer assembly. Another advantage of this method is that the deposition of poly‐L‐lysine/hyaluronic acid (PLL/HA) films in microchannels can be monitored online by fluorescence microscopy. The study demonstrates that PE mass transport to the film surface and diffusion in the film are key parameters affecting PLL/HA film build‐up. Increase of PE supply rate results in a change in the “transition” (exponential‐to‐linear growth) towards higher number of deposition steps, thus indicating a mass transport‐mediated growth mechanism.
The pathophysiology of echopraxia/echolalia: Relevance to Gilles De La Tourette syndrome
Authors: Ganos Christos , Ogrzal Timo , Schnitzler Alfons , Münchau Alexander 
Published: July 2012

AbstractEchopraxia and echolalia are subsets of imitative behavior. They are essential developmental elements in social learning. Their persistence or reemergence after a certain age, though, can be a sign of underlying brain dysfunction. Although echophenomena have been acknowledged as a typical sign in Gilles de la Tourette syndrome (GTS) since its first description, their clinical significance and neural correlates are largely unknown. Here, we review the course of their scientific historical development and focus on their clinical phenomenology and differential diagnosis with a particular view to GTS. The neural basis of echophenomena will also be addressed. © 2012 Movement Disorder Society
Novel chipless RF identification technology for on‐touch data transfer applications
Authors: Nair Sreejith M. , Shameena V. A. , Nijas M. , Mohanan P. 
Published: July 2012

AbstractThis article presents the design and development of a simple low‐cost chipless RFID system for secure near field data transfer.This system is ideal for use in credit cards, personal data keeping cards, and similar identification cards which are based on “data transfer by contact” which at present commonly uses the integrated circuits or magnetic strips in it. The proposed system consists of a compactable low‐cost RFID tag and a reader using a rectangular waveguide. © 2012 Wiley Periodicals, Inc. Microwave Opt Technol Lett 54:2325–2327, 2012; View this article online at wileyonlinelibrary.com. DOI 10.1002/mop.27044
Erratum: Compact wideband LTCC bandstop filter using vertical coupled‐line units
Authors: Qian Kewei , Tang Xiao‐Hong 
Published: July 2012

AbstractOriginal article published Microwave Opt Technol Lett 54:1173–1176, 2012.© 2012 Wiley Periodicals, Inc. Microwave Opt Technol Lett 54: 2445, 2012; View this article online at wileyonlinelibrary.com. DOI 10.1002/mop.27047 (Original article DOI 10.1002/mop.26787)
A miniaturized switchable circularly polarized patch antenna controlled by a single diode operation
Authors: Pyo Seongmin , Shin Imseob 
Published: July 2012

AbstractA novel switchable circularly polarized patch antenna with a compact size is proposed that uses only a single PIN diode. The proposed antenna consists of a corner‐truncated square radiating patch with a cross‐shaped slot on the ground, a triangular conductor, and one PIN diode. Because of the cross ground slot which is embedded on the diagonal direction, the resonant frequencies of each circular polarization sense are lowered about 41% for right‐hand circular polarization and 38% for left‐hand circular polarization. Moreover, by alternating the states of only one diode, a circular polarization sense is easily reconfigured without a radiating degradation. The simulated and measured results show that good CP characteristics are obtained with symmetrical radiation patterns at the lowered resonant frequencies. © 2012 Wiley Periodicals, Inc. Microwave Opt Technol Lett 54:2375–2378, 2012; View this article online at wileyonlinelibrary.com. DOI 10.1002/mop.27070
Dual‐mode dual‐band bandpass filter design using open‐loop resonators
Authors: Liu Haiwen , Zhao Yulong , Shi Liyun , Luo Hui 
Published: July 2012

AbstractThis letter presents a novel dual‐band bandpass filter using dual‐mode open‐loop resonator. Non‐degenerate modes of the dual‐mode resonator are excited by loading a center‐loaded T‐shaped stub and its nature is investigated through the even‐odd mode analysis. Based on the aforementioned dual‐mode resonators, a compact dual‐band filter is designed. Results verify that the fabricated filter with the central frequencies of 1.8 and 2.4 GHz and the fractional bandwidth of 8.3 and 12.9% are obtained. Also, there are several transmission zeros located at both sides of each passband. It provides the filter with improved selectivity and stopband suppression. © 2012 Wiley Periodicals, Inc. Microwave Opt Technol Lett 54:2370–2372, 2012; View this article online at wileyonlinelibrary.com.. DOI 10.1002/mop.27080
Anomalous forerunners in wave propagation: A temporal analysis
Authors: Ranfagni Anedio , Cacciari Ilaria , Agresti Alessandro , Mignani Roberto , Petrucci Andrea 
Published: July 2012

AbstractThe problem of the interpretation of anomalous forerunners as observed in microwave propagation experiments is re‐examined within the framework of a simpler model as compared to the one previously adopted. Furthermore, a time‐dependent analysis according to a saddle‐point procedure is developed. © 2012 Wiley Periodicals, Inc. Microwave Opt Technol Lett 54:2246–2248, 2012; View this article online at wileyonlinelibrary.com. DOI 10.1002/mop.27083