bluuebunny/crossref_metadata_2025_split huggingface dataset:
Relationship between obesity and foot pain and its association with fat mass, fat distribution, and muscle mass
Authors: Tanamas Stephanie K. , Wluka Anita E. , Berry Patricia , Menz Hylton B. , Strauss Boyd J. , Davies‐Tuck Miranda , Proietto Joseph , Dixon John B. , Jones Graeme , Cicuttini Flavia M. 
Published: October 2011

AbstractObjectiveTo examine the relationship between obesity, body composition, and foot pain as assessed by the Manchester Foot Pain and Disability Index (MFPDI).MethodsSubjects 25–62 years of age (n = 136) were recruited as part of a study examining the relationship between obesity and musculoskeletal health. Foot pain was defined as current foot pain and pain in the last month, and an MFPDI score of ≥1. Body composition (tissue mass and fat distribution) was measured using dual x‐ray absorptiometry.ResultsThe body mass index (BMI) in this population was normally distributed around a mean of 32.1 kg/m2. The prevalence of foot pain was 55.1%. There was a positive association between BMI and foot pain (odds ratio [OR] 1.11, 95% confidence interval [95% CI] 1.06–1.17). Foot pain was also positively associated with fat mass (OR 1.05, 95% CI 1.02–1.09) and fat mass index (FMI; OR 1.16, 95% CI 1.06–1.28) when adjusted for age, sex, and skeletal muscle mass and age, sex, and fat‐free mass index (FFMI), respectively. When examining fat distribution, positive associations were observed for android/total body fat ratio (OR 1.42, 95% CI 1.11–1.83) and android/gynoid fat ratio (OR 35.15, 95% CI 2.60–475.47), although gynoid/total body fat ratio was inversely related to foot pain (OR 0.83, 95% CI 0.73–0.93). Skeletal muscle mass and FFMI were not associated with foot pain when adjusted for fat mass or FMI, respectively.ConclusionIncreasing BMI, specifically android fat mass, is strongly associated with foot pain and disability. This may imply both biomechanical and metabolic mechanisms.
Association analysis of ANK3 gene variants in nordic bipolar disorder and schizophrenia case–control samples
Authors: Tesli Martin , Koefoed Pernille , Athanasiu Lavinia , Mattingsdal Morten , Gustafsson Omar , Agartz Ingrid , Rimol Lars M. , Brown Andrew , Wirgenes Katrine V. , Smorr Lisa‐Lena , Kähler Anna K. , Werge Thomas , Mors Ole , Mellerup Erling , Jönsson Erik G. , Melle Ingrid , Morken Gunnar , Djurovic Srdjan , Andreassen Ole A. 
Published: October 2011

AbstractGenetic variants in ankyrin 3 (ANK3) have recently been shown to be associated with bipolar disorder (BD). We genotyped three ANK3 SNPs previously found to be associated with BD (rs10994336, rs1938526, and rs9804190) in a Scandinavian BD case–control sample (N = 854/2,614). Due to evidence of genetic overlap between BD and schizophrenia (SZ), we also genotyped these three SNPs in a Scandinavian SZ case–control sample (N = 1,073/2,919). Combining our Scandinavian samples with an Icelandic sample (N = 435 BD cases, 651 SZ cases, and 11,491 healthy controls), we found rs10994336 and rs9804190 to be nominally significantly associated with BD in this combined Nordic BD sample (N = 1,289/14,105). Nominal P was 0.015/0.018 (fixed/random effect) for rs10994336 (Bonferroni corrected P = 0.044/0.053) and 0.023 for rs9804190 (Bonferroni corrected P = 0.069). None of the SNPs were significantly associated with SZ in the combined Nordic SZ case–control sample (N = 1,724/14,410). These results further support that ANK3 is a susceptibility gene specific to BD and that more than one risk locus is involved. © 2011 Wiley Periodicals, Inc.
Effect of adamantyl methacrylate on the thermal and mechanical properties of thermosensitive poly(N‐isopropylacrylamide) hydrogels
Authors: Zhu Dongyu , Lu Mangeng , Guo Jianwei , Liang Liyan , Lan Yanxun 
Published: October 2011

AbstractA series of thermosensitive hydrogels containing adamantyl groups were fabricated by copolymerization of N‐isopropylacrylamide and adamantyl methacrylate (AdMA). The thermal properties of such copolymeric hydrogels were studied by differential scanning calorimetry. The mechanical properties were emphasized through compression, tension, and dynamic mechanical analysis (DMA). Moreover, Rubber elasticity theory was used to evaluate the network parameters based on compressive stress–strain measurements. The results indicate that both the microstructure and physical properties strongly depend on the quantity of AdMA in the copolymeric gels. As the content of AdMA increases, the volume phase transition temperature of hydrogels decreases linearly, and the mechanical strength can be significantly improved, the effective crosslinking density (νe) increases monotonously, while the polymer‐water interaction parameter (χ) decreases first and then increases with AdMA content. © 2011 Wiley Periodicals, Inc. J Appl Polym Sci, 2012
Crystallization behaviors and mechanical performance of polypropylene/tetrapod‐shaped zinc oxide whisker composites
Authors: Bianying Wen , Binbin Ji 
Published: October 2011

AbstractPolypropylene (PP)/tetrapod‐shaped zinc oxide whisker (T‐ZnOw) composites are prepared via a melt‐mixing method in combination with a Haake rheometer. Differential scanning calorimetery (DSC) is used to investigate the nonisothermal and isothermal crystallization behaviors of the composites. Crystalline morphology is observed using hot‐stage optical microscopy, and the mechanical performance of the composites is investigated. Results indicate that T‐ZnOw has no heterogeneous nucleation effect on PP; in fact, it retards the growth of the crystal. Filled T‐ZnOw in PP matrix decreases the peak crystallization and melting temperatures of PP. T‐ZnOw shows either a reinforcing or toughening effect on the PP matrix at very lower weight ratios. These effects, however, decline with increasing T‐ZnOw contents because the size of the spherulitic crystals becomes bigger. © 2011 Wiley Periodicals, Inc. J Appl Polym Sci, 2012
Supercritical fluid processing of Nafion® membranes: Methanol permeability and proton conductivity
Authors: Pulido Ayazo Juan C. , Suleiman David 
Published: October 2011

AbstractNafion® membranes commonly used in direct methanol fuel cells (DMFC) are typically limited by high methanol permeability. These membranes have phase‐segregated sulfonated ionic domains in a perfluorinated backbone, which make processing difficult and limited by phase equilibria considerations. This study used supercritical fluids (SCFs) as a processing alternative, since the gas‐like mass transport properties of SCFs allow for better penetration into the membranes and the use of polar cosolvents could also influence their morphology, thus fine‐tuning their physical and transport properties. The SCF processing was performed at 40°C and 200 bars using pure CO2 and CO2 with several polar cosolvents of different size and chemical functionalities like: acetic acid, acetone, acetonitrile, cyclohexanone, dichloromethane, ethanol, isopropanol, methanol, and tetrahydrofuran. Methanol permeability measurements revealed that the SCF processed membranes reduced the permeation of methanol by several orders of magnitude, especially with the use of some small polar cosolvents. Proton conductivity measurements, using AC electrochemical impedance spectroscopy, were on the order of 0.03–0.09 S/cm, which indicates that processing with SCF CO2 plus some cosolvents maintained the high proton conductivity while reducing the methanol permeability. The results are explained using XRD and SAXS. XRD analysis of the SCF processed samples revealed an increasing pattern in the crystallinity, which influenced the transport properties of the membrane. SAXS measurements confirmed the morphological differences that led to the changes in transport properties of the SCF processed membranes. Finally, processing flow direction (parallel versus perpendicular flow) played a major role in the morphological changes of this anisotropic membrane. © 2011 Wiley Periodicals, Inc. J Appl Polym Sci, 2012
Differential Expression of Estrogen Receptors in Two Hippocampal Regions During the Estrous Cycle of the Rat
Authors: Mendoza‐garcés Luciano , Mendoza‐rodríguez Carmen Adriana , Jiménez‐trejo Francisco , Picazo Ofir , rodríguez María Carmen , Cerbón Marco 
Published: October 2011

AbstractIn the hippocampus, estrogens increase dendritic arborization, long‐term potentiation, neuroprotection, and participate in many functions related with learning, memory, and affective behaviors. The presence of both estrogen receptors alpha (ERα) and beta (ERβ) isoforms has been described in the hippocampus where they play different physiological roles. The aim of this study was to investigate, by using both techniques immunohistochemistry and Western Blot, the expression pattern of ERα and ERβ in the hippocampus of the rat along the estrous cycle. Western blot analysis was used to confirm the specificity of the antibodies used against ERα and ERβ and its relative content in the hippocampus. Results from immunohistochemical studies indicate that ERβ expression increased more than the ERα in CA1 and CA3 regions during all phases of the estrous cycle. ERβ immunoreactivity was mainly located in the nucleus and predominantly expressed in CA1 during estrous and metestrus, and in CA3 during diestrus. ERα was more abundant during estrous in comparison to other phases of the cycle in CA1 region, while it was more abundant during metestrus in CA3. Interestingly, the immunolocalization of ERα subtype was both cytoplasmic and nuclear. The overall results indicate that there is a differential expression, cellular localization, and distribution of both ER subtypes in CA1 and CA3 regions, suggesting different roles for these two receptors in the hippocampus along the estrous cycle. Anat Rec, 2011. © 2011 Wiley‐Liss, Inc.
Involvement of activation of Toll‐like receptors and nucleotide‐binding oligomerization domain–like receptors in enhanced IgG4 responses in autoimmune pancreatitis
Authors: Watanabe Tomohiro , Yamashita Kouhei , Fujikawa Saori , Sakurai Toshiharu , Kudo Masatoshi , Shiokawa Masahiro , Kodama Yuzo , Uchida Kazushige , Okazaki Kazuichi , Chiba Tsutomu 
Published: October 2011

AbstractObjectiveIgG4‐related disease is a recently recognized entity affecting multiple organs, including the pancreas, biliary tracts, and salivary glands. Although IgG4‐related disease is characterized by systemic IgG4 antibody responses and by infiltration of IgG4‐expressing plasma cells, the innate immune responses leading to adaptive IgG4 antibody responses are poorly understood. The aim of this study was to clarify the innate immune responses leading to IgG4 antibody production.MethodsIgG4 and cytokine responses to various nucleotide‐binding oligomerization domain (NOD)–like receptor (NLR) and Toll‐like receptor (TLR) ligands were examined using peripheral blood mononuclear cells (PBMCs) from healthy control subjects and patients with IgG4‐related autoimmune pancreatitis.ResultsActivation of NOD‐2 in monocytes from healthy control subjects induced IgG4 production by B cells in a BAFF‐dependent and T cell–independent manner. In addition, PBMCs from patients with IgG4‐related disease produced a large amount of IgG4 upon stimulation with NLR and TLR ligands; this enhanced IgG4 production was associated with the induction of BAFF by NLR and TLR ligands. Monocytes from patients with IgG4‐related disease induced IgG4 production by B cells from healthy control subjects upon stimulation with NLR and TLR ligands.ConclusionThe results of these studies suggest that abnormal innate immune responses against microbial antigens may underlie the immunopathogenesis of IgG4‐related disease.
Microarray analysis reveals age‐related differences in gene expression during the development of osteoarthritis in mice
Authors: Loeser Richard F. , Olex Amy L. , McNulty Margaret A. , Carlson Cathy S. , Callahan Michael F. , Ferguson Cristin M. , Chou Jeff , Leng Xiaoyan , Fetrow Jacquelyn S. 
Published: October 2011

AbstractObjectiveTo better understand the contribution of age to the development of osteoarthritis (OA).MethodsSurgical destabilization of the medial meniscus (DMM) was used to model OA in 12‐week‐old and 12‐month‐old male C57BL/6 mice. OA severity was evaluated histologically. RNA used for microarray and real‐time polymerase chain reaction analysis was isolated from joint tissue collected from the medial side of the joint, including cartilage, meniscus, subchondral bone, and the joint capsule with synovium. Computational analysis was used to identify patterns of gene expression, and immunohistochemistry was used to evaluate tissue distribution of selected proteins.ResultsOA was more severe in older mice than in young mice. Only 55 genes showed a similar expression with DMM‐induced OA in the 2 age groups, while 493 genes showed differential expression, the majority having increased expression in older mice. Functional categories for similarly expressed genes included extracellular matrix– and cell adhesion–related genes; differentially expressed genes included those related to muscle structure and development and immune response genes. Comparison of expression in sham‐operated control joints revealed an age‐related decrease in matrix gene expression and an increase in immune and defense response gene expression. Interleukin‐33 was present in multiple joint tissue cells, while CCL21 was more localized to chondrocytes and meniscal cells. Periostin was found in the extracellular matrix of cartilage and meniscus.ConclusionAge affects both the basal pattern of gene expression in joint tissues and the response to surgically induced OA. Examining tissue from the joint beyond only cartilage revealed novel genes and proteins that would be important to consider in OA.
Interleukin‐21 promotes osteoclastogenesis in humans with rheumatoid arthritis and in mice with collagen‐induced arthritis
Authors: Kwok Seung‐Ki , Cho Mi‐La , Park Mi‐Kyung , Oh Hye‐Joa , Park Jin‐Sil , Her Yang‐Mi , Lee Seon‐Yeong , Youn Jeehee , Ju Ji Hyeon , Park Kyung Su , Kim Sung‐Il , Kim Ho‐Youn , Park Sung‐Hwan 
Published: October 2011

AbstractObjectiveBone destruction is a critical pathology involved in the functional disability caused by rheumatoid arthritis (RA). Osteoclasts, which are specialized bone‐resorbing cells regulated by cytokines such as RANKL, are implicated in bone destruction in RA. The aim of this study was to determine whether interleukin‐21 (IL‐21), a potent immunomodulatory 4–α‐helical bundle type 1 cytokine, has osteoclastogenic activity in patients with RA and in mice with collagen‐induced arthritis (CIA).MethodsThe expression of IL‐21 in synovial tissue was examined using immunohistochemistry. The concentrations of IL‐21 in serum and synovial fluid were determined by enzyme‐linked immunosorbent assay. The levels of RANKL and osteoclastogenic markers were measured using real‐time polymerase chain reaction. CD14+ monocytes from patients with RA or mouse bone marrow cells were cocultured with fibroblast‐like synoviocytes (FLS) from patients with RA or CD4+ T cells from mice with CIA in the presence of IL‐21 and subsequently stained for tartrate‐resistant acid phosphatase activity to determine osteoclast formation.ResultsIL‐21 was up‐regulated in the synovium, synovial fluid, and serum of patients with RA and in the synovium and serum of mice with CIA. IL‐21 induced RANKL expression in mixed joint cells and CD4+ T cells from mice with CIA and in CD4+ T cells and FLS from patients with RA. Moreover, IL‐21 enhanced in vitro osteoclastogenesis without the presence of RANKL‐providing cells and by inducing RANKL expression in CD4+ T cells and FLS.ConclusionOur data suggest that IL‐21 promotes osteoclastogenesis in RA. We believe that therapeutic strategies targeting IL‐21 might be effective for the treatment of patients with RA, especially in preventing bone destruction.
Interleukin‐17–positive mast cells contribute to synovial inflammation in spondylarthritis
Authors: Noordenbos Troy , Yeremenko Nataliya , Gofita Ioana , van de Sande Marleen , Tak Paul P. , Caňete Juan D. , Baeten Dominique 
Published: October 2011

AbstractObjectiveStudies comparing spondylarthritis (SpA) to rheumatoid arthritis (RA) synovitis suggest that innate immune cells may play a predominant role in the pathogenesis of SpA. Recent observations have indicated a marked synovial mast cell infiltration in psoriatic SpA. We therefore undertook the present study to investigate the potential contribution of mast cells to synovial inflammation in SpA.MethodsSynovial tissue and fluid were obtained from patients with either nonpsoriatic or psoriatic SpA (n = 82) and patients with RA (n = 50). Synovial biopsy tissue was analyzed by immunostaining and used in ex vivo cultures. Synovial fluid was analyzed by enzyme‐linked immunosorbent assay.ResultsWe observed a strong and specific increase of c‐Kit–positive mast cells in the synovium from patients with SpA compared to the synovium from patients with RA synovitis, which was independent of disease subtype (nonpsoriatic versus psoriatic), disease duration, and treatment. Staining of mast cell granules, analysis of synovial fluid, and results in ex vivo tissue culture did not indicate increased degranulation in SpA synovitis. However, mast cells expressed significantly more interleukin‐17 (IL‐17) in SpA than in RA synovitis, and mast cells constituted the major IL‐17–expressing cell population in the SpA synovium. Ex vivo targeting of synovial mast cells with the c‐Kit inhibitor imatinib mesylate significantly decreased the production of IL‐17 as well as other proinflammatory cytokines in synovial tissue cultures. Analysis of paired pre‐ and posttreatment synovial tissue samples indicated that the mast cell/IL‐17 axis in SpA was not modulated by effective tumor necrosis factor (TNF) blockade.ConclusionThe specific and TNF‐independent increase in IL‐17–expressing mast cells may contribute to the progression of synovial inflammation in peripheral SpA.
Application of plasma surface modification techniques to improve hemocompatibility of vascular grafts: A review
Authors: Solouk Atefeh , Cousins Brian G. , Mirzadeh Hamid , Seifalian Alexander M. 
Published: October 2011

AbstractSurface modification using plasma processing can significantly change the chemical and physical characteristics of biomaterial surfaces. When used in combination with additional modification techniques such as direct chemical or biochemical methods, it can produce novel biomaterial surfaces, which are anticoagulant, bioactive, and biomimetic in nature. This article reviews recent advances in improving hemocompatibility of biomaterials by plasma surface modification (PSM). The focus of this review is on PSM of the most commonly used polymers for vascular prostheses such as expanded polytetrafluoroethylene (PTFE), polyethylene terephthalate (Dacron®), and next generation of biomaterials, including polyhedral oligomeric silsesquioxane nanocomposite.
Friend or foe: In enjoying playfulness, do innovative consumers tend to switch brand?
Authors: Aroean Lukman 
Published: October 2011

ABSTRACTPlayful consumption has been an extraordinary phenomenon in the modern era, but little attention has been paid to how likely innovative consumers are to seek to enjoy this particular experience. Using structural equation modeling and invariant tests, this article examines empirically the relationship between innovativeness, brand switching, and playful consumption, with gender and age as moderators. Innovativeness has been found to predict playful consumption, and although it also predicts brand switching, interestingly, the latter was not found to predict playful consumption. That, for innovative consumers, encountering playfulness is not enhanced by different brands suggests that being able to enjoy playful rewards requires familiarity, which is more likely to be provided by ongoing rather than by new brands. This article therefore presents a friendly message for marketers: In enjoying playfulness, innovative consumers tend not to switch brand. More theoretical and practical implications, as well as future research, are also identified.Copyright © 2011 John Wiley & Sons, Ltd.
Using Alba Emoting™ to work with emotions in psychotherapy
Authors: Kalawski Juan Pablo 
Published: October 2011

Alba Emoting™ is a physical method to help recognize, induce, express and regulate the basic emotions. This is achieved through specific breathing, postural and facial behaviours. Alba Emoting is based on psychophysiological research by Susana Bloch and her collaborators, who have applied this method mainly to train actors. Alba Emoting can be used in psychotherapy to facilitate emotion awareness, regulation and transformation. It can also help therapists better recognize their own and their clients' emotions. The application of Alba Emoting in psychotherapy is illustrated with a case example. Copyright © 2011 John Wiley & Sons, Ltd.Key Practitioner Message

Alba Emoting is a physical, scientific method for working with emotions.
Alba Emoting can help therapists better recognize their own and their clients' emotions.
Alba Emoting can help clients achieve better emotional awareness and regulation.
Alba Emoting can also help clients experience and express emotions they may normally inhibit.
Unfolding personalities: The importance of studying ontogeny
Authors: Groothuis Ton G.G. , Trillmich Fritz 
Published: October 2011

AbstractWe aim to stimulate an ontogenetic approach to personalities. We explain the importance of studying development for understanding proximate and ultimate aspects of personality and critically discuss, partly by perhaps provocative statements, our current lack of knowledge and potential approaches to the study of personality development. We first clarify some terminology and argue for a difference between behavioral profiles (BP; at the descriptive level) and personality (at the explanatory level). We then focus on the issue of temporal stability of personality, arguing that based on evolutionary theory, neurophysiological knowledge, and recent findings, personality is probably less stable than often thought. Next we consider the potential influence of genes, discussing gene by environment correlations and interactions and argue that developmental changes in the regulation of DNA expression are probably more relevant than individual differences in DNA sequence. We end by suggesting perspectives for future research. © 2011 Wiley Periodicals, Inc. Dev Psychobiol 53:641–655, 2011.
Similarity in temperament between mother and offspring rhesus monkeys: Sex differences and the role of monoamine oxidase‐a and serotonin transporter promoter polymorphism genotypes
Authors: Sullivan Erin C. , Mendoza Sally P. , Capitanio John P. 
Published: October 2011

AbstractTemperament is usually considered biologically based and largely inherited, however, the environment can shape the development of temperament. Allelic variation may confer differential sensitivity to early environment resulting in variations in temperament. Here we explore the relationship between measures of temperament in mothers and their first‐born offspring and the role of genetic sensitivity in establishing the strength of these associations. Temperament ratings were conducted on 3‐ to 4‐month‐old rhesus monkeys after a 25‐hr biobehavioral assessment. Factor analysis revealed a four‐factor structure of temperament. Females assessed as infants have reproduced and their offspring have also been evaluated through the standardized testing paradigm. Canonical correlation analysis revealed statistically significant associations between factor scores of mothers and sons, but not mothers and daughters. Further, offspring possessing the high activity, “low risk,” alleles of therhMAOA‐LPRorrh5‐HTTLPRshowed statistically significant canonical correlations, whereas those possessing other alleles did not, suggesting differential genetic sensitivity to the normative early experience of maternal temperament. © 2011 Wiley Periodicals, Inc. Dev Psychobiol 53:549–563, 2011.