bluuebunny/crossref_metadata_2025_split huggingface dataset:
Symptoms of depression in ICU physicians
Authors: Embriaco Nathalie , Hraiech Sami , Azoulay Elie , Baumstarck-Barrau Karine , Forel Jean-Marie , Kentish-Barnes Nancy , Pochard Frédéric , Loundou Anderson , Roch Antoine , Papazian Laurent 
Published: July 2012

AbstractBackgroundWork and family are the two domains from which most adults develop satisfaction in life. They also are responsible for stressful experiences. There is a perception in the community that work is increasingly the source of much of our stress and distress. Depressive symptoms may be related to repeated stressful experiences. Intensive care unit (ICU) physicians are exposed to major stressors. However, the existence of depressive symptoms in these doctors has been poorly studied. This study was designed to evaluate the prevalence and associated risk factors of depressive symptoms in junior and senior ICU physicians.MethodA one-day national survey was conducted in adult intensive care units (ICU) in French public hospitals. Symptoms of depression were assessed using the Centers of Epidemiologic Studies Depression Scale (CES-D).ResultsA total of 189 ICUs participated, and 901 surveys were returned (75.8% response rate). Symptoms of depression were found in 23.8% of the respondents using the CES-D scale. Fifty-eight percent of these intensivists presenting symptoms of depression wished to leave their job compared with only 33% of those who did not exhibit signs of depression as assessed by the CES-D scale (p < 0.0001). Multiple logistic regression showed that organizational factors were associated with the presence of depressive symptoms. Workload (long interval since the last nonworking weekend, absence of relief of service until the next working day after a night shift) and impaired relationships with other intensivists were independently associated with the presence of depressive symptoms. A high level of burnout also was related to the presence of depressive symptoms. In contrast, no demographic factors regarding ICU physicians and no factor related to the severity of illness of patients were retained by the model. The quality of relationships with other physicians (from other departments) was associated with the absence of depressive symptoms (protective effect).ConclusionsApproximately one of four intensivists presented symptoms of depression. The next step could be to test whether organization modification is associated with less depressive symptoms and less desire to leave the job.
Root anoxia effects on physiology and emissions of volatile organic compounds (VOC) under short-and long-term inundation of trees from Amazonian floodplains
Authors: Bracho-Nunez Araceli , Knothe Nina Maria , Costa Wallace R , Maria Astrid Liberato R , Kleiss Betina , Rottenberger Stefanie , Piedade Maria Teresa Fernandez , Kesselmeier Jürgen 
Published: July 2012

AbstractVolatile organic compound (VOC) emissions are affected by a variety of biotic and abiotic factors such as light intensity, temperature, CO2and drought. Another stress factor, usually overlooked but very important for the Amazon region, is flooding. We studied the exchange of VOCs in relation to CO2exchange and transpiration of 8 common tree species from the Amazonian floodplain forest grown up from seeds using a dynamic enclosure system. Analysis of volatile organics was performed by PTR-MS fast online measurements. Our study confirmed emissions of ethanol and acetaldehyde at the beginning of root anoxia after inundation, especially in less anoxia adapted species such asVatairea guianensis, but not forHevea spruceanaprobably due to a better adapted metabolism. In contrast to short-term inundation, long-term flooding of the root system did not result in any emission of ethanol or/and acetaldehyde. Emission of other VOCs, such as isoprenoids, acetone, and methanol exhibited distinct behavior related to the origin (igapó or várzea type of floodplain) of the tree species. Also physiological activities exhibited different response patterns for trees from igapó or várzea. In general, isoprenoid emissions increased within the course of some days of short-term flooding. After a long period of waterlogging, VOC emissions decreased considerably, along with photosynthesis, transpiration and stomatal conductance. However, even under long-term testing conditions, two tree species did not show any significant decrease or increase in photosynthesis. In order to understand ecophysiological advantages of the different responses we need field investigations with adult tree species.
Monocyte populations as markers of response to adalimumab plus MTX in rheumatoid arthritis
Authors: Chara Luis , Sánchez-Atrio Ana , Pérez Ana , Cuende Eduardo , Albarrán Fernando , Turrión Ana , Chevarria Julio , Sánchez Miguel A , Monserrat Jorge , de la Hera Antonio , Prieto Alfredo , Sanz Ignacio , Diaz David , Alvarez-Mon Melchor 
Published: July 2012

Abstract
Introduction
The treatment of rheumatoid arthritis (RA) patients with anti-tumor necrosis factor alpha (TNFα) biological drugs has dramatically improved the prognosis of these patients. However, a third of the treated patients do not respond to this therapy. Thus, the search for biomarkers of clinical response to these agents is currently highly active. Our aim is to analyze the number and distribution of circulating monocytes, and of their CD14+highCD16-, CD14+highCD16+ and CD14+lowCD16+ subsets in methotrexate (MTX) non-responder patients with RA, and to determine their value in predicting the clinical response to adalimumab plus MTX treatment.

Methods
This prospective work investigated the number of circulating monocytes, and of their CD14+highCD16-, CD14+highCD16+ and CD14+lowCD16+ subsets, in 35 MTX non-responder patients with RA before and after three and six months of anti-TNFα treatment using multiparametric flow cytometry. The number of circulating monocytes in an age- and sex-matched healthy population was monitored as a control.

Results
Non-responder patients with RA show an increased number of monocytes and of their CD14+highCD16-, CD14+highCD16+ and CD14+lowCD16+ subsets after three months of adalimumab plus MTX treatment that remained significantly increased at six months. In contrast, significant normalization of the numbers of circulating monocytes was found in responders at three months of adalimumab plus MTX treatment that lasts up to six months. CX3CR1 expression is increased in monocytes in non-responders. At three months of anti-TNFα treatment the number of circulating monocytes and their subsets was associated with at least 80% sensitivity, 84% specificity and an 86% positive predictive value (PPV) in terms of discriminating between eventual early responders and non-responders.

Conclusions
The absolute number of circulating monocytes and of their CD14+highCD16-, CD14+highCD16+ and CD14+lowCD16+ subsets at three months of adalimumab plus MTX treatment, have a predictive value (with high specificity and sensitivity) in terms of the clinical response after six months of anti-TNFα treatment in patients with RA.
Sustained low efficiency dialysis using a single-pass batch system in acute kidney injury - a randomized interventional trial: the REnal Replacement Therapy Study in Intensive Care Unit PatiEnts
Authors: Schwenger Vedat , Weigand Markus A , Hoffmann Oskar , Dikow Ralf , Kihm Lars P , Seckinger Jörg , Miftari Nexhat , Schaier Matthias , Hofer Stefan , Haar Caroline , Nawroth Peter P , Zeier Martin , Martin Eike , Morath Christian 
Published: July 2012

Abstract
Introduction
Acute kidney injury (AKI) is associated with a high mortality of up to 60%. The mode of renal replacement therapy (intermittent versus continuous) has no impact on patient survival. Sustained low efficiency dialysis using a single-pass batch dialysis system (SLED-BD) has recently been introduced for the treatment of dialysis-dependent AKI. To date, however, only limited evidence is available in the comparison of SLED-BD versus continuous veno-venous hemofiltration (CVVH) in intensive care unit (ICU) patients with AKI.

Methods
Prospective, randomized, interventional, clinical study at a surgical intensive care unit of a university hospital. Between 1 April 2006 and 31 January 2009, 232 AKI patients who underwent renal replacement therapy (RRT) were randomized in the study. Follow-up was assessed until 30 August 2009. Patients were either assigned to 12-h SLED-BD or to 24-h predilutional CVVH. Both therapies were performed at a blood flow of 100 to 120 ml/min.

Results
115 patients were treated with SLED-BD (total number of treatments n = 817) and 117 patients with CVVH (total number of treatments n = 877).The primary outcome measure, 90-day mortality, was similar between groups (SLED: 49.6% vs. CVVH: 55.6%, P = 0.43). Hemodynamic stability did not differ between SLED-BD and CVVH, whereas patients in the SLED-BD group had significantly fewer days of mechanical ventilation (17.7 ± 19.4 vs. 20.9 ± 19.8, P = 0.047) and fewer days in the ICU (19.6 ± 20.1 vs. 23.7 ± 21.9, P = 0.04). Patients treated with SLED needed fewer blood transfusions (1,375 ± 2,573 ml vs. 1,976 ± 3,316 ml, P = 0.02) and had a substantial reduction in nursing time spent for renal replacement therapy (P < 0.001) resulting in lower costs.

Conclusions
SLED-BD was associated with reduced nursing time and lower costs compared to CVVH at similar outcomes. In the light of limited health care resources, SLED-BD offers an attractive alternative for the treatment of AKI in ICU patients.

Trial registration
ClinicalTrials.gov NCT00322530
Prediction of severe community-acquired pneumonia: a systematic review and meta-analysis
Authors: Marti Christophe , Garin Nicolas , Grosgurin Olivier , Poncet Antoine , Combescure Christophe , Carballo Sebastian , Perrier Arnaud 
Published: July 2012

Abstract
Introduction
Severity assessment and site-of-care decisions for patients with community-acquired pneumonia (CAP) are pivotal for patients' safety and adequate allocation of resources. Late admission to the intensive care unit (ICU) has been associated with increased mortality in CAP. We aimed to review and meta-analyze systematically the performance of clinical prediction rules to identify CAP patients requiring ICU admission or intensive treatment.

Methods
We systematically searched Medline, Embase, and the Cochrane Controlled Trials registry for clinical trials evaluating the performance of prognostic rules to predict the need for ICU admission, intensive treatment, or the occurrence of early mortality in patients with CAP.

Results
Sufficient data were available to perform a meta-analysis on eight scores: PSI, CURB-65, CRB-65, CURB, ATS 2001, ATS/IDSA 2007, SCAP score, and SMART-COP. The estimated AUC of PSI and CURB-65 scores to predict ICU admission was 0.69. Among scores proposed for prediction of ICU admission, ATS-2001 and ATS/IDSA 2007 scores had better operative characteristics, with a sensitivity of 70% (CI, 61 to 77) and 84% (48 to 97) and a specificity of 90% (CI, 82 to 95) and 78% (46 to 93), but their clinical utility is limited by the use of major criteria.
ATS/IDSA 2007 minor criteria have good specificity (91% CI, 84 to 95) and moderate sensitivity (57% CI, 46 to 68). SMART-COP and SCAP score have good sensitivity (79% CI, 69 to 97, and 94% CI, 88 to 97) and moderate specificity (64% CI, 30 to 66, and 46% CI, 27 to 66). Major differences in populations, prognostic factor measurement, and outcome definition limit comparison. Our analysis also highlights a high degree of heterogeneity among the studies.

Conclusions
New severity scores for predicting the need for ICU or intensive treatment in patients with CAP, such as ATS/IDSA 2007 minor criteria, SCAP score, and SMART-COP, have better discriminative performances compared with PSI and CURB-65. High negative predictive value is the most consistent finding among the different prediction rules. These rules should be considered an aid to clinical judgment to guide ICU admission in CAP patients.
SNX5 is essential for efficient macropinocytosis and antigen processing in primary macrophages
Authors: Lim Jet Phey , Teasdale Rohan D. , Gleeson Paul A. 
Published: July 2012

SummaryMacropinocytosis mediates the bulk endocytosis of solute molecules, nutrients and antigens. As this endocytic pathway is considered important in functions associated with immune responses, the molecular mechanisms regulating this pathway in immune cells is of particular significance. However, the regulators of macropinocytosis in primary cells remain poorly defined. Members of the sorting nexin (SNX) family have been implicated in macropinosome biogenesis in cultured cells and here we have analyzed the role of two SNX family members, SNX1 and its binding partner SNX5, in macropinocytosis of mouse primary macrophages. We show that endogenous SNX1 and SNX5 are localised to newly-formed macropinosomes in primary mouse macrophages and, moreover, demonstrate that SNX5 plays an essential role in macropinosome biogenesis. Depletion of SNX5 in bone marrow-derived macrophages dramatically decreased both the number and size of macropinosomes. Depletion of SNX5 also resulted in dramatic reduction in uptake and processing of soluble ovalbumin in macrophages, indicating that the majority of antigen uptake and delivery to late endosomes is via macropinocytosis. By contrast, the absence of SNX1 had no effect on endogenous SNX5 localisation and macropinosome biogenesis using macrophages from SNX1 knockout mice. Therefore, SNX5 can function independently of SNX1 and is a modulator of macropinocytosis that influences the uptake and processing of soluble antigen in primary mouse macrophages.
Correction of dorsally-malunited extra-articular distal radial fractures using volar locked plates without bone grafting
Authors: Mahmoud M. , El Shafie S. , Kamal M. 
Published: July 2012

Malunion is the most common complication of the distal radius with many modalities of treatment available for such a problem. The use of bone grafting after an osteotomy is still recommended by most authors. We hypothesised that bone grafting is not required; fixing the corrected construct with a volar locked plate helps maintain the alignment, while metaphyseal defect fills by itself. Prospectively, we performed the procedure on 30 malunited dorsally-angulated radii using fixed angle volar locked plates without bone grafting. At the final follow-up, 22 wrists were available. Radiological evidence of union, correction of the deformity, clinical and functional improvement was achieved in all cases. Without the use of bone grafting, corrective open wedge osteotomy fixed by a volar locked plate provides a high rate of union and satisfactory functional outcomes.
Oxford phase 3 unicompartmental knee replacement in Korean patients
Authors: Lim H-C. , Bae J-H. , Song S-H. , Kim S-J. 
Published: July 2012

Medium-term survivorship of the Oxford phase 3 unicompartmental knee replacement (UKR) has not yet been established in an Asian population. We prospectively evaluated the outcome of 400 phase 3 Oxford UKRs in 320 Korean patients with a mean age at the time of operation of 69 years (48 to 82). The mean follow-up was 5.2 years (1 to 10). Clinical and radiological assessment was carried out pre- and post-operatively. At five years, the mean Knee Society knee and functional scores had increased significantly from 56.2 (30 to 91) pre-operatively to 87.2 (59 to 98) (p = 0.034) and from 59.2 (30 to 93) to 88.3 (50 to 100) (p = 0.021), respectively. The Oxford knee score increased from a mean of 25.8 (12 to 39) pre-operatively to 39.8 (25 to 58) at five years (p = 0.038). The ten-year survival rate was 94% (95% confidence interval 90.1 to 98.0). A total of 14 UKRs (3.5%) required revision. The most common reason for revision was dislocation of the bearing in 12 (3%). Conversion to a total knee replacement was required in two patients who developed osteoarthritis of the lateral compartment.This is the largest published series of UKR in Korean patients. It shows that the mid-term results after a minimally invasive Oxford phase 3 UKR can yield satisfactory clinical and functional results in this group of patients.
Association Between CASP8 and CASP10 Polymorphisms and Toxicity Outcomes With Platinum-Based Chemotherapy in Chinese Patients With Non-Small Cell Lung Cancer
Authors: Qian Ji , Qu Hui-Qi , Yang Lixin , Yin Ming , Wang Qiming , Gu Shaohua , Wu Qihan , Zhao Xueying , Wu Wenting , Wu Junjie , Tan Xiaoming , Chen Wenqing , Wang Haijian , Wang Jiucun , Fan Weiwei , Chen Hongyan , Han Baohui , Lu Daru , Wei Qingyi , Jin Li 
Published: July 2012

Abstract
Caspase-8 and caspase-10 play crucial roles in both cancer development and chemotherapy efficacy. In this study, we aimed to comprehensively assess single nucleotide polymorphisms (SNPs) of the caspase-8 (CASP8) and caspase-10 (CASP10) genes in relation to toxicity outcomes with first-line platinum-based chemotherapy in patients with advanced non-small cell lung cancer (NSCLC). We genotyped 13 tag SNPs of CASP8 and CASP10 in 663 patients with advanced NSCLC treated with platinum-based chemotherapy regimens. Associations between SNPs and chemotherapy toxicity outcomes were identified in a discovery set of 279 patients and then validated in an independent set of 384 patients. In both the discovery and validation sets, variant homozygotes of CASP8 rs12990906 and heterozygotes of CASP8 rs3769827 and CASP10 rs11674246 and rs3731714 had a significantly lower risk for severe toxicity overall. However, only the association with the rs12990906 variant was replicated in the validation set for hematological toxicity risk. In a stratified analysis, we found that some other SNPs, including rs3769821, rs3769825, rs7608692, and rs12613347, were significantly associated with severe toxicity risk in some subgroups, such as in nonsmoking patients, patients with adenocarcinoma, and patients treated with cisplatin combinations. Consistent results were also found in haplotype analyses. Our results provide novel evidence that polymorphisms in CASP8 and CASP10 may modulate toxicity outcomes in patients with advanced NSCLC treated with platinum-based chemotherapy. If validated, the findings will facilitate the genotype-based selection of platinum-based chemotherapy regimens.
Upper body musculoskeletal symptoms of Latino poultry processing workers and a comparison group of Latino manual workers
Authors: Schulz Mark R. , Grzywacz Joseph G. , Chen Haiying , Mora Dana C. , Arcury Thomas A. , Marín Antonio J. , Mirabelli Maria C. , Quandt Sara A. 
Published: July 2012

AbstractBackgroundUpper body musculoskeletal injuries are often attributed to rapid work pace and repetitive motions. These job features are common in poultry processing, an industry that relies on Latino immigrants. Few studies document the symptom burden of immigrant Latinos employed in poultry processing or other manual jobs.MethodsLatino poultry processing workers (n = 403) and a comparison population of 339 Latino manual workers reported symptoms for six upper body sites during interviews. We tabulated symptoms and explored factors associated with symptom counts.ResultsBack symptoms and wrist/hand symptoms lasting more than 1‐day were reported by over 35% of workers. Poultry processing workers reported more symptoms than comparison workers, especially wrist and elbow symptoms. The number of sites at which workers reported symptoms was elevated for overtime workers and workers who spoke an indigenous language during childhood.ConclusionWorkplace conditions facing poultry processing and indigenous language speaking workers deserve further exploration. Am. J. Ind. Med. 56:197–205, 2013. © 2011 Wiley Periodicals, Inc.
Employer, use of personal protective equipment, and work safety climate: Latino poultry processing workers
Authors: Arcury Thomas A. , Grzywacz Joseph G. , Anderson Andrea M. , Mora Dana C. , Carrillo Lourdes , Chen Haiying , Quandt Sara A. 
Published: July 2012

AbstractBackgroundThis analysis describes the work safety climate of Latino poultry processing workers and notes differences by worker personal characteristics and employer; describes the use of common personal protective equipment (PPE) among workers; and examines the associations of work safety climate with use of common PPE.MethodsData are from a cross‐sectional study of 403 Latino poultry processing workers in western North Carolina.ResultsWork safety climate differed little by personal characteristics, but it did differ consistently by employer. Provision of PPE varied; for example, 27.2% of participants were provide with eye protection at no cost, 57.0% were provided with hand protection at no cost, and 84.7% were provided with protective clothing at no cost. PPE use varied by type. Provision of PPE at no cost was associated with lower work safety climate; this result was counter‐intuitive. Consistent use of PPE was associated with higher work safety climate.ConclusionsWork safety climate is important for improving workplace safety for immigrant workers. Research among immigrant workers should document work safety climate for different employers and industries, and delineate how work safety climate affects safety behavior and injuries. Am. J. Ind. Med. 56:180–188, 2013. © 2011 Wiley Periodicals, Inc.
Fluid Phase Equilibria of the Binary Systems N2 + Ethane and N2 + Pentane Between 88 K and 313 K and at Pressures up to 200 MPa
Authors: Wisotzki K. D. , Schneider G. M. 
Published: July 2012

AbstractBinary mixtures of nitrogen with ethane and pentane, respectively, were investigated at pressures up to 200 MPa in an optical high‐pressure low‐temperature cell according to the synthetic method. The experimental p(T) isopleths show that both systems exhibit upper critical solution temperatures (UCST) at high pressures. The resulting critical curves start at the critical point of the pure alkane, respectively. With decreasing temperatures the critical p(T) curve of the system nitrogen + pentane runs to higher pressures exhibiting a positive curvature whereas the critical curve of the system nitrogen + ethane firstly goes through a slight pressure maximum and minimum successively and then runs steeply to increasing pressures showing a positive curvature, too. The critical curve of the system nitrogen + ethane ends at a critical end point on the three‐phase line lls ((176 ± 2) MPa, (105 ± 0.3) K) where two liquid phases become identical in the presence of solid ethane.
Molecular Photodissociation Dynamics Revealed by Multiphoton Ionisation Spectroscopy
Authors: Ashfold M. N. R. , Bayley J. M. , Dixon R. N. , Prince J. D. 
Published: July 2012

AbstractThis article highlights the utility of multiphoton ionisation Spectroscopy to studies of the predissociation dynamics of Rydberg states in small polyatomic molecules. Predissociation from various of the excited states of H2O, H2S and their respective deuterated analogues is demonstrated to be a sensitive function of parent rotational level and to be critically affected by H ↔ D isotopic substitution and by accidental near resonances with more heavily predissociated “doorway” states which provide more efficient coupling into the background continuum of dissociative levels.
The Photodissociation of Propynal
Authors: Brühlmann U. , Russegger P. , Stafast H. , Robert Huber J. 
Published: July 2012

AbstractThe lowest reaction channel on the electronic ground state potential surface of propynal HC  CCHO → HC  CH + CO as well as its calculated energy barrier have been examined by UV photolysis and by IR multiphoton decomposition.