bluuebunny/crossref_metadata_2025_split huggingface dataset:
Identifying predictors and determining mortality rates of septic cardiomyopathy and sepsis-related cardiogenic shock: A retrospective, observational study
Authors: Hendrickson Kathryn W. , Cirulis Meghan M. , Burk Rebecca E. , Lanspa Michael J. , Peltan Ithan D. , Marshall Hunter , Groat Danielle , Jephson Al , Beesley Sarah J. , Brown Samuel M. 
Published: April 2024

Introduction
Septic shock is a severe form of sepsis that has a high mortality rate, and a substantial proportion of these patients will develop cardiac dysfunction, often termed septic cardiomyopathy (SCM). Some SCM patients may develop frank cardiac failure, termed sepsis-related cardiogenic shock (SeRCS). Little is known of SeRCS. This study describes baseline characteristics of patients with SCM and SeRCS compared to patients with septic shock without cardiac dysfunction. We compare clinical outcomes among SCM, SeRCS, and septic shock, and identify risk factors for the development of SCM and SeRCS.

Methods
Septic patients admitted to the ICU with an echocardiogram obtained within 72 hours were included. Left ventricular ejection fraction of ≤55% was used to define SCM, and cardiac index ≤2.1 L/min/m2 among patients with SCM defined SeRCS. Machine learning was used to identify risk factors for development of SCM and SeRCS. Logistic regression was used to compare mortality among groups.

Results
Among 1229 patients, 977 patients had septic shock without cardiac dysfunction, 207 had SCM, and 45 had SeRCS. In patients with septic shock, the strongest predictor for developing SCM and SeRCs was a prior history of cardiac dysfunction. Mortality did not significantly differ among the three groups.

Conclusions
SCM and SeRCS affect a minority of patients with septic shock, disproportionately affecting individuals with a history of cardiac disease. We did not identify a mortality difference associated with SCM or SeRCS. Additional work is needed to define further subtypes and treatment options for this patient population.
Joint observation in NICU (JOIN): A randomized controlled trial testing an early, one-session intervention during preterm care to improve perceived maternal self-efficacy and other mental health outcomes
Authors: Schneider Juliane , Harari Mathilde Morisod , Faure Noémie , Lacroix Alain , Borghini Ayala , Tolsa Jean-François , Horsch Antje ,   on behalf of the JOIN Research Consortium
Published: April 2024

Background
Parents of preterm infants in the Neonatal Intensive Care Unit (NICU) environment may experience psychological distress, decreased perceived self-efficacy, and/or difficulties in establishing an adaptive parent-infant relationship. Early developmental care interventions to support the parental role and infant development are essential and their impact can be assessed by an improvement of parental self-efficacy perception. The aims were to assess the effects of an early intervention provided in the NICU (the Joint Observation) on maternal perceived self-efficacy compared to controls (primary outcome) and to compare maternal mental health measures (perceived stress, anxiety, and depression), perception of the parent-infant relationship, and maternal responsiveness (secondary outcomes).

Methods
This study was a monocentric randomized controlled trial registered in clinicatrials.gov (NCT02736136), which aimed at testing a behavioural intervention compared with treatment-as-usual. Mothers of preterm neonates born 28 to 32 6/7 weeks gestation were randomly allocated to either the intervention or the control groups. Outcome measures consisted of self-report questionnaires completed by the mothers at 1 and 6 months after enrollment and assessing perceived self-efficacy, mental health, perception of the parent-infant relationship and responsiveness, as well as satisfaction with the intervention.

Results
No statistically significant group effects were observed for perceived maternal self-efficacy or the secondary outcomes. Over time, perceived maternal self-efficacy increased for mothers in both groups, while anxiety and depression symptoms decreased. High satisfaction with the intervention was reported.

Conclusions
The joint observation was not associated with improved perceived maternal self-efficacy or other mental health outcomes, but may constitute an additional supportive measure offered to parents in a vulnerable situation during the NICU stay.
Cervical spine immobilisation following blunt trauma in pre-hospital and emergency care: A systematic review
Authors: Pandor Abdullah , Essat Munira , Sutton Anthea , Fuller Gordon , Reid Stuart , Smith Jason E. , Fothergill Rachael , Surendra Kumar Dhushy , Kolias Angelos , Hutchinson Peter , Perkins Gavin D. , Wilson Mark H. , Lecky Fiona 
Published: April 2024

Objectives
To assess whether different cervical spine immobilisation strategies (full immobilisation, movement minimisation or no immobilisation), impact neurological and/or other outcomes for patients with suspected cervical spinal injury in the pre-hospital and emergency department setting.

Design
Systematic review following Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines.

Data sources
MEDLINE, EMBASE, CINAHL, Cochrane Library and two research registers were searched until September 2023.

Eligibility criteria
All comparative studies (prospective or retrospective) that examined the potential benefits and/or harms of immobilisation practices during pre-hospital and emergency care of patients with a potential cervical spine injury (pre-imaging) following blunt trauma.

Data extraction and synthesis
Two authors independently selected and extracted data. Risk of bias was appraised using the Cochrane ROBINS-I tool for non-randomised studies. Data were synthesised without meta-analysis.

Results
Six observational studies met the inclusion criteria. The methodological quality was variable, with most studies having serious or critical risk of bias. The effect of cervical spine immobilisation practices such as full immobilisation or movement minimisation during pre-hospital and emergency care did not show clear evidence of benefit for the prevention of neurological deterioration, spinal injuries and death compared with no immobilisation. However, increased pain, discomfort and anatomical complications were associated with collar application during immobilisation.

Conclusions
Despite the limited evidence, weak designs and limited generalisability, the available data suggest that pre-hospital cervical spine immobilisation (full immobilisation or movement minimisation) was of uncertain value due to the lack of demonstrable benefit and may lead to potential complications and adverse outcomes. High-quality randomised comparative studies are required to address this important question.

Trial registration
PROSPERO REGISTRATION Fiona Lecky, Abdullah Pandor, Munira Essat, Anthea Sutton, Carl Marincowitz, Gordon Fuller, Stuart Reid, Jason Smith. A systematic review of cervical spine immobilisation following blunt trauma in pre-hospital and emergency care. PROSPERO 2022 CRD42022349600 Available from: https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42022349600.
Research practice, satisfaction, motivation, and challenges among university academics in Kurdistan Region of Iraq
Authors: Ahmed Hamdia Mirkhan , Alkhateeb Nazdar Ezzaddin , Shabila Nazar P. , Ahmad Amir Abdulrahman 
Published: April 2024

Background
Researchers in universities and academic institutions must be in a leading position in generating research evidence to inform and direct national policies and strategies, improve service delivery, and achieve the main objectives. This study aimed to determine the factors that promote or hinder research productivity and quality among university academics in Kurdistan Region of Iraq.

Methods
A cross-sectional study was conducted on 949 university academics from all public universities in the Kurdistan Region of Iraq. The authors developed a questionnaire that included sociodemographic data, challenges, satisfaction, and motivation for conducting research. Data were collected using a Google form. Frequencies, percentages, and the Chi-square test were used to analyze the data.

Results
Most university academics (94.6%) believed that research was part of their job, but only 51.6% were satisfied with their role as academic researchers. The lack of financial motivation was the main reason for dissatisfaction, while the main incentive to conduct research was the passion for science. Around 21% of the university academics had not published any research, while 53.1% published 1–5 articles. Half of the participants (49.7%) lacked training in writing research proposals, and the majority (86.1%) have not applied for international grants. Approximately half of university academics (46.9%) shared their research findings with stakeholders, and the primary method was by sharing their published papers (59.4%), followed by seminars (42.2%). One of the important challenges in conducting research was the lack of funding (62.8%).

Conclusions
The academics at universities in the Kurdistan Region of Iraq are passionate about their role as researchers, but face many challenges in conducting effective research. A strategic plan is needed to provide an encouraging environment for university academics regarding infrastructure, financial, and technical support. More studies are needed to identify the root factors of academic staff needs and challenges.
Direct and indirect effects of CYTOR lncRNA regulate HIV gene expression
Authors: Kuzmina Alona , Sadhu Lopamudra , Hasanuzzaman Md , Fujinaga Koh , Schwartz Jacob C. , Fackler Oliver T. , Taube Ran 
Published: April 2024

The implementation of antiretroviral therapy (ART) has effectively restricted the transmission of Human Immunodeficiency Virus (HIV) and improved overall clinical outcomes. However, a complete cure for HIV remains out of reach, as the virus persists in a stable pool of infected cell reservoir that is resistant to therapy and thus a main barrier towards complete elimination of viral infection. While the mechanisms by which host proteins govern viral gene expression and latency are well-studied, the emerging regulatory functions of non-coding RNAs (ncRNA) in the context of T cell activation, HIV gene expression and viral latency have not yet been thoroughly explored.
Here, we report the identification of the Cytoskeleton Regulator (CYTOR) long non-coding RNA (lncRNA) as an activator of HIV gene expression that is upregulated following T cell stimulation. Functional studies show that CYTOR suppresses viral latency by directly binding to the HIV promoter and associating with the cellular positive transcription elongation factor (P-TEFb) to activate viral gene expression. CYTOR also plays a global role in regulating cellular gene expression, including those involved in controlling actin dynamics. Depletion of CYTOR expression reduces cytoplasmic actin polymerization in response to T cell activation. In addition, treating HIV-infected cells with pharmacological inhibitors of actin polymerization reduces HIV gene expression. We conclude that both direct and indirect effects of CYTOR regulate HIV gene expression.
Reducing Eosinophil Counts in Eosinophilic Esophagitis in Children Is Associated With Reduction in Later Stricture Development
Authors: Strauss Starling Alexandra , Ren Yue , Li Hongzhe , Spergel Jonathan M. , Muir Amanda B. , Lynch Kristle L. , Liacouras Chris A. , Falk Gary W. 
Published: April 2024

INTRODUCTION:
There are limited longitudinal data on the impact of chronic therapy on the natural history of eosinophilic esophagitis (EoE), a chronic allergic disease of the esophagus. The purpose of this study was to evaluate if patients with well-controlled EoE were less likely to develop fibrostenotic complications.

METHODS:
Subjects were identified from a database of pediatric patients with EoE at the Children's Hospital of Philadelphia started in 2000. Patients were then searched in adult medical records to identify patients who transitioned care. All office visits, emergency department visits, and endoscopic, histologic, and imaging reports were reviewed for the primary outcome of strictures and the secondary outcomes of food impactions and dysphagia. Cox proportional hazard regression was performed for outcomes.

RESULTS:
One hundred five patients were identified with the mean follow-up of 11.4 ± 4.9 years. 52.3% (n = 55) had a period of histologic disease control defined as ≥2 consecutive endoscopies with histologic remission. These patients were less likely to develop strictures compared with patients who did not have a period of histologic control (HR 0.232; 95% CI 0.084–0.64, P = 0.005). Patients who were diagnosed at younger ages were less likely to develop strictures. Presentation with dysphagia or impaction was associated with higher rate of stricture development.

DISCUSSION:
In this cohort study with > 10 years of follow-up, children with EoE with a period of histologic disease control and diagnosed at younger ages were less likely to develop esophageal strictures. While this suggests histologic remission is associated with reduction of remodeling complications, additional prospective data with long-term follow-up are needed.
Florence Marryat’s Sensational Ecologies of Empire, 1865–1897: Imaginary Tropics, White Proto-Feminism, and a Comforting Plantationocene
Authors: Espinoza Garrido Felipe 
Published: April 2024

Abstract
Among Florence Marryat’s vast canon of work, scholars have mostly focused on her spiritualism, her alleged proto-feminism, and, not least, the racial politics of her most famous novel, The Blood of the Vampire (1897). Little attention, however, has been paid to the role of her abundant nature imaginations that infuse most of her colonial fictions. Among these, Marryat’s decades-spanning engagement with ‘the tropics’ stands out, ranging from the miasmic and deceitful Caribbean in Too Good for Him (1865), the lush Brazilian jungles of Her Father’s Name (1876), the glimpses of post-revolutionary Haitian Voodoo in A Daughter of the Tropics (1887) to the plantation settings of A Crown of Shame (1888) and The Blood of the Vampire. With attention to Marryat’s ecological fictions, I argue that these novels’ allegedly liberatory rhetoric marks the tropics of the Caribbean and the Americas as a distinct epistemic problem for the imperial project, in that they confound the affective balance of white, English perception, and colonial desire. As a result, charting, understanding, and thereby re-mastering ‘nature’ are framed as foundational processes for white – often specifically female – self-awareness. Written in the wake of the brutally curbed 1865 Jamaican Morant Bay Rebellion, Marryat’s tropics thus lament not women’s social exclusion per se but specifically white women’s exclusion from the imperial project. Ultimately, the nature encounter in Marryat’s tropics offers proto-feminist empire fictions as a remedy for the perceived erosion of the late nineteenth-century plantation ecologies.
“She is the Great Outside”: Ecofeminist Potentiality in H. G. Wells’s The Sea Lady
Authors: Kalthoff Katharina Andrea 
Published: April 2024

Abstract
H. G. Wells’s serial fable The Sea Lady (1902) offers a satirical commentary on the Victorian Age: It draws a societal allegory that criticises both a cohesive conception of the natural world, and Victorian notions of the domestic realm – in the private and national sense of the term. Yet the story has long been regarded as an oddity in the author’s oeuvre. Wells’s Victorian contemporaries criticised its lack of scientific detail so characteristic of his more successful scientific romances. The reason for this appears to be the story’s eponymous central figure – a mermaid, supposedly rather the stuff of legend, folklore and fairy tales. However, by opening up a utopian realm in which ‘better dreams’ await, the figure of the sea lady destabilises Victorian moral orders as a potential discovery of the future lingers on the horizon of the century’s turn. In this article, I foreground the story’s ecofeminist potential by analysing the intersections between its unconventional form, the ‘untameable female’ protagonist at its centre, and the specific oceanic and littoral environments it presents.
Quality control in the Netherlands; todays practices and starting points for guidance and future research
Authors: van Rossum Huub H. , van Schrojenstein Lantman Marith , Severens Michel , Vermeer Henricus J. , Verboeket-van de Venne Wilhelmine P.H.G. , Oosterhuis Wytze , de Jonge Niels 
Published: April 2024

Abstract

Objectives
Adequate analytical quality of reported results is primarily ensured by performing internal quality control (iQC). Currently, several different iQC practices are in use. As a prelude to the revision of a Dutch guidance document on analytical QC, a questionnaire was sent out to gain insights in the applied practices and the need for guidance.

Methods
A questionnaire, containing 20 multiple-choice questions with possibilities for explanation and comment on iQC practices and aspects was distributed to all clinical chemistry laboratories within the Netherlands. Results were reported descriptively.

Results
Responses were received from 27 clinical laboratories (response 43 %). In 30 % the iQC was based on the analytical characteristics only, while 30 % used a 6-Sigma method, 19 % risk-based beyond 6-Sigma and 22 % used an alternative approach. 89 % of laboratories used a virtual analyzer model for iQC setup within one or more laboratory sites. Practices for determining standard deviation (SD) values included determining SD for each new iQC material (35 %), using historical SD values for new materials (35 %), and incorporating clinical tolerances into the SD value (31 %). Furthermore, 44 % of laboratories used patient moving averages for one or more tests. Daily iQC management was based on either “traffic lights” indicating in or out of control status, and review of all QC charts, often using multiple software systems.

Conclusions
A large heterogeneity of iQC practices in clinical laboratories was observed in the Netherlands. Several starting points for further research and/or guidance were identified, particularly in relation to the determination of SD values, the virtual analyzer model and methods to ensure analyzer equivalence.
A miniaturized dual band pass frequency selective surface insensitive to oblique angles and polarizations of wave
Authors: Shah Gulab , Cao Qunsheng , Ahmed Afzal , Wang Bin 
Published: April 2024

Abstract
A Dualband Pass Frequency Selective Structure (DPSFSS) with miniaturized elements is proposed in this article. The miniaturized elements induce high inductance and capacitance values. The meandered line concept is used which extensively increases inductance of the dipole element. Very large capacitance is obtained between two meandered elements which have wide common area perpendicular to electric field for wave propagating in Z-direction. Two pass band poles and two zeros are obtained by perpendicular arrangement of meandered patterns on two sides of the substrate. Orthogonal arrangement of patterns ensure polarization symmetry (polarization insensitive) for Transverse Electric (TE) and Transverse Magnetic (TM) modes of exciting wave. Two pass band pole frequencies are positioned at 1.84 GHz and 4.53 GHz with low Insertion Losses (IL) of 0.67 dB and 1 dB, respectively. The lower and higher frequency bands have factional bandwidths of 41 % and 46 %, respectively. The transmission nulls occupy 2.8 GHz and 6.58 GHz frequencies. The structure is miniaturized to 0.032λ
0 × 0.032λ
0 dimensions with respect to lowest resonance residing at 1.83 GHz. The low IL at both pass bands is realized despite of using a lossy FR-4 material that can be improved to less than 0.5 dB at both the bands using less lossy materials such as F4BME or RO4003C. The proposed DPSFSS design is elaborated using Equivalent Circuit Model (ECM) and Surface Current Distribution (SCD). Measurements are performed on fabricated DPSFSS prototype and it is observed that the measured results coincide well with the simulated response. Angle stability of the DPSFSS is excellent and no unwanted resonances are observed at oblique angles upto 80° for dual polarizations of wave.
Optimization of the temperature profile of cake batter in an ohmic heating – assisted printing nozzle for 3D food printing applications
Authors: Niane Mamadou L. , Rouaud Olivier , Ogé Anthony , Quéveau Delphine , Le-Bail Alain , Le-Bail Patricia 
Published: April 2024

Abstract
3D printing of food has great potential for applications such as the design of customised food or the creation of innovative textures. However, printed products often do not retain their structure due to the composition of the material, especially in the case of cereal products. Cooking such products with a nozzle could be an alternative to meet this challenge. The objective of this work was to develop, with the help of a numerical model, a 3D cake batter printing nozzle in which ohmic heating is used for baking. The use of a temperature and shear rate dependent viscosity allowed the solidification of the batter during baking due to starch gelatinization. The numerical model made it possible to predict heterogeneity in temperature distribution. Optimization procedures were used to reach desired temperature profiles at the outlet of the nozzle, reducing by 17 % the electrical power used for heating and by 78 % the energy evacuated during cooling.
Analgesia nociception index is an indicator of laparoscopic trocar insertion-induced transient nociceptive stimuli
Authors: Liu Jun , Wang Zhuodan , Huang Wan , Cheng Nan , Chen Weiqiang , Wu Weijun , Li Shangrong 
Published: April 2024

Abstract

Objective
This study aimed to investigate whether analgesia nociception index (ANI) could be an indicator of perioperative pain during laparoscopic trocar insertion.

Methods
A total of 280 participants of anesthesia receiving laparoscopic surgery were enrolled. Anesthesia induction and maintenance were performed using the Marsh model for target propofol and the Minto model for remifentanil. Systolic blood pressure (SBP), heart rate (HR), and ANI were recorded at skin incision, the first-, second, the last-trocar insertion, and 5 min after the last trocar insertion.

Results
ANI was significantly different among the five groups in the last four time points (all P < 0.05). Pearson’s correlation showed that ANI was negatively correlated with SBP (r = −0.114, P = 0.077) and HR (r = −0.247, P < 0.001). The area under the curve of ANI was positively correlated with those of SBP (r = 0.493, P < 0.001) and HR (r = −0.420, P < 0.001). Multivariate logistic regression showed that the ANI was an independent factor associated with intraoperative hemodynamic adverse events only at 5 min after the last trocar insertion.

Conclusions
Under general anesthesia, the change in ANI was consistent with changes in the balance between analgesia and nociceptive stimuli. The ANI can reflect the extent of transient pain but had a poor predictive performance for hemodynamic adverse events.