bluuebunny/crossref_metadata_2025_split huggingface dataset:
On–off and proportional–integral controller for a morphing wing. Part 1: Actuation mechanism and control design
Authors: Grigorie T L , Popov A V , Botez R M , Mamou M , Mébarki Y 
Published: November 2011

The main objective of this research work is the development of an actuation control concept for a new morphing actuation mechanism made of smart materials, which is built from a shape memory alloy (SMA). Two lines of smart actuators were incorporated to a rectangular wing to modify the upper wing surface, made of a flexible skin, with the intention to move the laminar-to-turbulent transition point closer to the wing trailing edge. After a brief introduction of the morphing wing system architecture and requirements, the actuation lines' design and instrumentation are presented. The integrated controller controls the SMA actuators via an electrical current supply, so that the transducer position can be used to eliminate the deviation between the required values for vertical displacements (corresponding to the optimized airfoils) and their physical values. The final configuration of the integrated controller is a combination of a bi-positional (on–off) controller and a PI (proportional–integral) controller, due to the two heating and cooling phases of the SMA wires' interconnection. This controller must behave like a switch between the cooling and the heating phases, situations where the output current is 0 A, or is controlled by a PI type law. The PI controller for the heating phase is optimally tuned using integral and surface minimum error criteria (Ziegler–Nichols). The controller is numerically tested on the linear identified system in terms of time response, Bode diagram, amplitude and phase stability margins, and root-locus.
Verifying a questionnaire diagnosis of asthma in children using health claims data
Authors: Yang Connie L , To Teresa , Foty Richard G , Stieb David M , Dell Sharon D 
Published: November 2011

AbstractBackgroundChildhood asthma prevalence is widely measured by parental proxy report of physician-diagnosed asthma in questionnaires. Our objective was to validate this measure in a North American population.MethodsThe 2884 study participants were a subsample of 5619 school children aged 5 to 9 years from 231 schools participating in the Toronto Child Health Evaluation Questionnaire study in 2006. We compared agreement between "questionnaire diagnosis" and a previously validated "health claims data diagnosis". Sensitivity, specificity and kappa were calculated for the questionnaire diagnosis using the health claims diagnosis as the reference standard.ResultsPrevalence of asthma was 15.7% by questionnaire and 21.4% by health claims data. Questionnaire diagnosis was insensitive (59.0%) but specific (95.9%) for asthma. When children with asthma-related symptoms were excluded, the sensitivity increased (83.6%), and specificity remained high (93.6%).ConclusionsOur results show that parental report of asthma by questionnaire has low sensitivity but high specificity as an asthma prevalence measure. In addition, children with "asthma-related symptoms" may represent a large fraction of under-diagnosed asthma and they should be excluded from the inception cohort for risk factor studies.
Dysglycemia induces abnormal circadian blood pressure variability
Authors: Kumarasamy Sivarajan , Gopalakrishnan Kathirvel , Kim Dong Hyun , Abraham Nader G , Johnson William D , Joe Bina , Gupta Alok K 
Published: November 2011

Abstract

Background
Prediabetes (PreDM) in asymptomatic adults is associated with abnormal circadian blood pressure variability (abnormal CBPV).

Hypothesis
Systemic inflammation and glycemia influence circadian blood pressure variability.

Methods
Dahl salt-sensitive (S) rats (n = 19) after weaning were fed either an American (AD) or a standard (SD) diet. The AD (high-glycemic-index, high-fat) simulated customary human diet, provided daily overabundant calories which over time lead to body weight gain. The SD (low-glycemic-index, low-fat) mirrored desirable balanced human diet for maintaining body weight. Body weight and serum concentrations for fasting glucose (FG), adipokines (leptin and adiponectin), and proinflammatory cytokines [monocyte chemoattractant protein-1 (MCP-1) and tumor necrosis factor-α (TNF-α)] were measured. Rats were surgically implanted with C40 transmitters and blood pressure (BP-both systolic; SBP and diastolic; DBP) and heart rate (HR) were recorded by telemetry every 5 minutes during both sleep (day) and active (night) periods. Pulse pressure (PP) was calculated (PP = SBP-DBP).

Results
[mean(SEM)]: The AD fed group displayed significant increase in body weight (after 90 days; p < 0.01). Fasting glucose, adipokine (leptin and adiponectin) concentrations significantly increased (at 90 and 172 days; all p < 0.05), along with a trend for increased concentrations of systemic pro-inflammatory cytokines (MCP-1 and TNF-α) on day 90. The AD fed group, with significantly higher FG, also exhibited significantly elevated circadian (24-hour) overall mean SBP, DBP, PP and HR (all p < 0.05).

Conclusion
These data validate our stated hypothesis that systemic inflammation and glycemia influence circadian blood pressure variability. This study, for the first time, demonstrates a cause and effect relationship between caloric excess, enhanced systemic inflammation, dysglycemia, loss of blood pressure control and abnormal CBPV. Our results provide the fundamental basis for examining the relationship between dysglycemia and perturbation of the underlying mechanisms (adipose tissue dysfunction induced local and systemic inflammation, insulin resistance and alteration of adipose tissue precursors for the renin-aldosterone-angiotensin system) which generate abnormal CBPV.
Haptoglobin genotype predicts development of coronary artery calcification in a prospective cohort of patients with type 1 diabetes
Authors: Simpson Melissa , Snell-Bergeon Janet K , Kinney Gregory L , Lache Orit , Miller-Lotan Rachel , Anbinder Yefim , Rewers Marian J , Levy Andrew P 
Published: November 2011

Abstract

Background
Coronary artery disease has been linked with genotypes for haptoglobin (Hp) which modulates extracorpuscular hemoglobin. We hypothesized that the Hp genotype would predict progression of coronary artery calcification (CAC), a marker of subclinical atherosclerosis.

Methods
CAC was measured three times in six years among 436 subjects with type 1 diabetes and 526 control subjects participating in the Coronary Artery Calcification in Type 1 Diabetes (CACTI) study. Hp typing was performed on plasma samples by polyacrylamide gel electrophoresis.

Results
The Hp 2-2 genotype predicted development of significant CAC only in subjects with diabetes who were free of CAC at baseline (OR: 1.95, 95% CI: 1.07-3.56, p = 0.03), compared to those without the Hp 2-2 genotype, controlling for age, sex, blood pressure and HDL-cholesterol. Hp 2 appeared to have an allele-dose effect on development of CAC. Hp genotype did not predict CAC progression in individuals without diabetes.

Conclusions
Hp genotype may aid prediction of accelerated coronary atherosclerosis in subjects with type 1 diabetes.
Calcium-sensing receptor and calcium kidney stones
Authors: Vezzoli Giuseppe , Terranegra Annalisa , Rainone Francesco , Arcidiacono Teresa , Cozzolino Mario , Aloia Andrea , Dogliotti Elena , Cusi Daniele , Soldati Laura 
Published: November 2011

Abstract
Calcium nephrolithiasis may be considered as a complex disease having multiple pathogenetic mechanisms and characterized by various clinical manifestations. Both genetic and environmental factors may increase susceptibility to calcium stones; therefore, it is crucial to characterize the patient phenotype to distinguish homogeneous groups of stone formers. Family and twin studies have shown that the stone transmission pattern is not mendelian, but complex and polygenic. In these studies, heritability of calcium stones was calculated around 50%
Calcium-sensing receptor (CaSR) is mostly expressed in the parathyroid glands and in renal tubules. It regulates the PTH secretion according to the serum calcium concentration. In the kidney, it modulates electrolyte and water excretion regulating the function of different tubular segments. In particular, CaSR reduces passive and active calcium reabsorption in distal tubules, increases phosphate reabsorption in proximal tubules and stimulates proton and water excretion in collecting ducts. Therefore, it is a candidate gene for calcium nephrolithiasis.
In a case-control study we found an association between the normocitraturic stone formers and two SNPs of CaSR, located near the promoters region (rs7652589 and rs1501899). This result was replicated in patients with primary hyperparathyroidism, comparing patients with or without kidney stones. Bioinformatic analysis suggested that the minor alleles at these polymorphisms were able to modify the binding sites of specific transcription factors and, consequently, CaSR expression.
Our studies suggest that CaSR is one of the candidate genes explaining individual predisposition to calcium nephrolithiasis. Stone formation may be favored by an altered CaSR expression in kidney medulla involving the normal balance among calcium, phosphate, protons and water excretion.
A trial for the use of qigong in the treatment of pre and mild essential hypertension: a study protocol for a randomized controlled trial
Authors: Park Ji-Eun , Liu Yan , Park Taeseob , Hong Sanghoon , Kim Jung-Eun , Kim Tae-Hun , Kim Ae-Ran , Jung So-Young , Park Hyoju , Choi Sun-Mi 
Published: November 2011

Abstract

Background
Hypertension is a risk factor for cardiovascular disease, and the prevalence of hypertension tends to increase with age. Current treatments for hypertension have side effects and poor adherence. Qigong has been studied as an alternative therapy for hypertension; however, the types of qigong used in those studies were diverse, and there have not been many well-designed randomized controlled trials.
Our objectives are the following: 1) To evaluate the effects of qigong on blood pressure, health status and hormone levels for pre- or mild hypertension. 2) To test the methodological appropriateness of this clinical trial and calculate a sample size for future randomized trials.

Methods
Forty subjects with pre- or mild hypertension will be randomized to either the qigong exercise group or the non-treated group. Participants in the qigong group will conduct qigong exercises 5 times per week for 8 weeks, and participants in the non-treated group will maintain their current lifestyle, including diet and exercise. The use of antihypertensive medication is not permitted. The primary endpoint is a change in patient blood pressure. Secondary endpoints are patient health status (as measured by the SF-36 and the MYMOP2 questionnaires) and changes in hormone levels, including norepinephrine, epinephrine, and cortisol.

Discussion
This study will be the first randomized trial to investigate the effectiveness of qigong exercises for the treatment of pre- and mild hypertension. The results of this study will help to establish the optimal approach for the care of adults with pre- or mild hypertension.

Trial registration
Clinical Research Information Service KCT0000140
Nek family of kinases in cell cycle, checkpoint control and cancer
Authors: Moniz Larissa , Dutt Previn , Haider Nasir , Stambolic Vuk 
Published: November 2011

Abstract
Early studies in lower Eukaryotes have defined a role for the members of the NimA related kinase (Nek) family of protein kinases in cell cycle control. Expansion of the Nek family throughout evolution has been accompanied by their broader involvement in checkpoint regulation and cilia biology. Moreover, mutations of Nek family members have been identified as drivers behind the development of ciliopathies and cancer. Recent advances in studying the physiological roles of Nek family members utilizing mouse genetics and RNAi-mediated knockdown are revealing intricate associations of Nek family members with fundamental biological processes. Here, we aim to provide a comprehensive account of our understanding of Nek kinase biology and their involvement in cell cycle, checkpoint control and cancer.
Promoter de-methylation of cyclin D2 by sulforaphane in prostate cancer cells
Authors: Hsu Anna , Wong Carmen P , Yu Zhen , Williams David E , Dashwood Roderick H , Ho Emily 
Published: November 2011

Abstract
Sulforaphane (SFN), an isothiocyanate derived from cruciferous vegetables, induces potent anti-proliferative effects in prostate cancer cells. One mechanism that may contribute to the anti-proliferative effects of SFN is the modulation of epigenetic marks, such as inhibition of histone deacetylase (HDAC) enzymes. However, the effects of SFN on other common epigenetic marks such as DNA methylation are understudied. Promoter hyper-methylation of cyclin D2, a major regulator of cell cycle, is correlated with prostate cancer progression, and restoration of cyclin D2 expression exerts anti-proliferative effects on LnCap prostate cancer cells. Our study aimed to investigate the effects of SFN on DNA methylation status of cyclin D2 promoter, and how alteration in promoter methylation impacts cyclin D2 gene expression in LnCap cells. We found that SFN significantly decreased the expression of DNA methyltransferases (DNMTs), especially DNMT1 and DNMT3b. Furthermore, SFN significantly decreased methylation in cyclin D2 promoter regions containing c-Myc and multiple Sp1 binding sites. Reduced methlyation of cyclin D2 promoter corresponded to an increase in cyclin D2 transcript levels, suggesting that SFN may de-repress methylation-silenced cyclin D2 by impacting epigenetic pathways. Our results demonstrated the ability of SFN to epigenetically modulate cyclin D2 expression, and provide novel insights into the mechanisms by which SFN may regulate gene expression as a prostate cancer chemopreventive agent.
Comparing the effects of two inhaled glucocorticoids on allergen‐induced bronchoconstriction and markers of systemic effects, a randomised cross‐over double‐blind study
Authors: Lötvall Jan , Palmqvist Mona , Arvidsson Peter 
Published: November 2011

AbstractBackgroundInhaled glucocorticoids are efficient in protecting against asthma exacerbations, but methods to compare their efficacy vs systemic effects have only been attempted in larger multi‐centre studies. The aim of the current study was therefore to directly compare the effects of two separate inhaled glucocorticoids, mometasone and budesonide, to compare the effects on the early and late asthmatic responses to inhaled allergen in patients with mild allergic asthma, and sputum eosinophils, and to relate the clinical positive effects to any systemic effects observed.MethodsTwelve patients with documented early and late asthmatic responses (EAR and LAR) to inhaled allergen at a screening visit were randomized in a double‐blind fashion to treatment with mometasone (200 μg × 2 or 400 μg × 2), budesonide (400 μg × 2) or placebo in a double‐blind crossover fashion for a period of seven days. Challenge with the total allergen dose causing both an EAR and LAR was given on the last day of treatment taken in the morning. Lung function was assessed using FEV1, and systemic glucocorticoid activity was quantified using 24 h urinary cortisol.ResultsMometasone and budesonide attenuate both EAR and LAR to allergen to a similar degree. No significant dose‐related effects on the lung function parameters were observed. Both treatments reduced the relative amount of sputum eosinophils (%) after allergen. At the dose of 800 μg daily, mometasone reduced 24 h urinary cortisol by approximately 35%. Both drugs were well tolerated.ConclusionsMometasone and budesonide are equieffective in reducing early and late asthmatic responses induced by inhaled allergen challenge. Mometasone 800 μg given for seven days partially affects the HPA axis.
Application of a MANET Testbed for horizontal and vertical scenarios: performance evaluation using delay and jitter metrics
Authors: Hiyama Masahiro , Kulla Elis , Oda Tetsuya , Ikeda Makoto , Barolli Leonard 
Published: November 2011

AbstractMobile ad hoc networks are attracting attention for their potential use in several fields such as collaborative computing and communications in indoor areas. Mobility and the absence of any fixed infrastructure make MANETs very attractive for mobility and rescue operations and time-critical applications. Considering mobility of the terminals, routing is a key process for operation of MANETs. In this paper, we analyze the performance of Optimized Link State Routing protocol in an indoor environment considering different scenarios for horizontal and vertical topologies. We evaluate the scenarios based on delay and jitter metrics. The experimental results show that for vertical topology the performance is affected more by mobility and number of hops, in comparison with the horizontal topology.
A Case-Match Study Comparing Unilateral With Synchronous Bilateral Breast Cancer Outcomes
Authors: Nichol Alan M. , Yerushalmi Rinat , Tyldesley Scott , Lesperance Mary , Bajdik Chris D. , Speers Caroline , Gelmon Karen A. , Olivotto Ivo A. 
Published: November 2011

Purpose There is controversy about whether patients with synchronous bilateral breast cancer (SBBC) have similar or worse outcomes compared with patients with unilateral breast cancer. The purpose of this study was to determine whether survival outcomes for patients with SBBC can be estimated from the characteristics of their individual cancers. Patients and Methods Patients had invasive breast cancer, without metastases or inflammatory disease, diagnosed in British Columbia between 1989 and 2000. There were 207 cases with SBBC (diagnosed ≤ 2 months apart) and 15,497 with unilateral breast cancer. By using 10-year breast cancer–specific survival (BCSS) estimates, the higher-risk cancer of each SBBC case was determined and matched with three breast cancers from the unilateral cohort to select 621 high-risk matches. The priority sequence of matching the prognostic and predictive variables was positive lymph node number, primary tumor size, age, grade, lymphovascular invasion, estrogen receptor status, local therapy used, margin status, treating clinic, diagnosis year, and type of systemic therapy used. Results With a median follow-up of 10.2 years, the overall 10-year BCSS was significantly higher for the unilateral cohort (81%; 95% CI, 81% to 82%) than for the SBBC cases (71%; 95% CI, 63% to 77%). The SBBC cases had significantly higher mean age and stage at presentation. The 10-year BCSS was 74% (95% CI, 69% to 77%) for the high-risk matches. Conclusion BCSS was not significantly different between the SBBC cases and their high-risk matches.
Plasma MicroRNA Panel to Diagnose Hepatitis B Virus–Related Hepatocellular Carcinoma
Authors: Zhou Jian , Yu Lei , Gao Xue , Hu Jie , Wang Jiping , Dai Zhi , Wang Jie-Fei , Zhang Zhiyong , Lu Shaohua , Huang Xiaowu , Wang Zheng , Qiu Shuangjian , Wang Xiaoying , Yang Guohuan , Sun Huichuan , Tang Zhaoyou , Wu Ying , Zhu Hongguang , Fan Jia 
Published: November 2011

Purpose More than 60% of patients with hepatocellular carcinoma (HCC) do not receive curative therapy as a result of late clinical presentation and diagnosis. We aimed to identify plasma microRNAs for diagnosing hepatitis B virus (HBV) –related HCC. Patients and Methods Plasma microRNA expression was investigated with three independent cohorts including 934 participants (healthy, chronic hepatitis B, cirrhosis, and HBV-related HCC), recruited between August 2008 and June 2010. First, we used microarray to screen 723 microRNAs in 137 plasma samples for diagnosing HCC. Quantitative reverse-transcriptase polymerase chain reaction assay was then applied to evaluate the expression of selected microRNAs. A logistic regression model was constructed using a training cohort (n = 407) and then validated using an independent cohort (n = 390). Area under the receiver operating characteristic curve (AUC) was used to evaluate diagnostic accuracy. Results We identified a microRNA panel (miR-122, miR-192, miR-21, miR-223, miR-26a, miR-27a and miR-801) that provided a high diagnostic accuracy of HCC (AUC = 0.864 and 0.888 for training and validation data set, respectively). The satisfactory diagnostic performance of the microRNA panel persisted regardless of disease status (AUCs for Barcelona Clinic Liver Cancer stages 0, A, B, and C were 0.888, 0.888, 0.901, and 0.881, respectively). The microRNA panel can also differentiate HCC from healthy (AUC = 0.941), chronic hepatitis B (AUC = 0.842), and cirrhosis (AUC = 0.884), respectively. Conclusion We found a plasma microRNA panel that has considerable clinical value in diagnosing early-stage HCC. Thus, patients who would have otherwise missed the curative treatment window can benefit from optimal therapy.
Telangiectasia and venous reflux in the Edinburgh Vein Study
Authors: Ruckley C V , Allan P L , Evans C J , Lee A J , Fowkes F G R 
Published: November 2011

Objective The purpose of this study was to correlate the clinical findings in the Edinburgh Vein Study with the results of duplex scanning of the deep and superficial venous systems. Methods An age-stratified random sample of 1566 people (699 men and 867 women) aged 16–64 were selected from computerized age–sex registers of participating practices (twelve general practices with catchment areas geographically and socioeconomically distributed throughout Edinburgh). Screening included clinical examination, photography and duplex ultrasonography of the superficial veins and the deep veins down to popliteal level. Telangiectasia and varicose veins were graded 1–3 according to severity. Results Since there was good agreement between the duplex findings of the right versus left legs, the current analyses are based on 1092 subjects (486 men and 606 women) with complete duplex scan data in their left legs. There was no significant trend of increasing incompetence in either the deep veins only ( P = 0.214) or in the combined deep and superficial veins ( P = 0.111) with increasing severity of the telangiectasia. There was a statistically significant trend for increasing incompetence in (a) the superficial veins ( P = 0.006) and (b) either the superficial or deep veins ( P < 0.001) to be associated with advancing grade of telangiectasia. When stratified by gender, significant trends were maintained for male superficial vein incompetence and for either superficial or deep incompetence in both genders. Examination of incompetence in individual venous segments showed that increasing severity of telangiectasia was significantly associated with an increasing proportion of reflux in the upper and lower great saphenous and femoral vein segments. There was no significant association between small saphenous incompetence and increasing grade of telangiectasia. Conclusion There is a significant, but not wholly consistent, association between grade of telangiectasia and reflux in both the deep and superficial systems. This association does not apply to the small saphenous system.