bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sustained cooling comfort achieved through weft-knit spacer composite fabrics
Authors: Das Anik , Xu Lei , Shuofei Jia , Mia Rony , Assiri Mohammed A. 
Published: February 2025

This research introduces a groundbreaking weft-knitted spacer composite fabric designed for a continuous cool feeling effect. Fabrication involved a double-sided circular weft machine, incorporating ultra-high molecular weight polyethylene (UHMWPE) cool feeling fiber as the surface layer and carbon-coated nylon monofilament as the spacer layer. Quantitative assessments demonstrate a remarkable thermal conductivity of 0.329 W·m⁻1·K⁻1 for the developed fabric, significantly higher than the polyester spacer fabric used for comparison. The UHMWPE cool feeling fiber exhibited exceptional moisture conductivity and wettability, with a wicking height approaching 6 cm within the initial 3 minutes and a water contact angle of 44.47° after 40 seconds. This enables the capillary transport, diffusion, and evaporation of water molecules along the fiber surface. This process efficiently dissipates heat, resulting in a distinct tactile cool sensation. To further enhance the continuous cool feeling effect, the weft-knitted spacer fabric was integrated with needle-punched nonwoven fabrics containing phase change microcapsules (PCM) embedded viscose fiber. The PCM viscose fiber demonstrated a melting phase transition within 25–35°C, with an endothermic enthalpy of 6.48 J/g. This strategic incorporation not only amplifies the fabric’s cooling capabilities but also introduces an advanced dimension of temperature regulation, maintaining a temperature difference of approximately 1.2°C between the upper and lower surfaces of the composite fabric. The findings underscore the fabric’s multifaceted advantages, positioning it as a promising solution for diverse applications. Infrared thermal imaging revealed the composite fabric’s ability to maintain a lower surface temperature over time compared to polyester spacer fabric, while compression recovery tests showed its capacity to provide good mechanical support with a distinctive three-stage compression process. The innovative integration of materials yields a fabric with superior thermal and moisture management properties, making it ideal for applications ranging from advanced apparel to innovative seating materials. The quantitative thermal conductivity result, coupled with the synergistic effects of UHMWPE cool feeling fiber and PCM microcapsules, underscores the fabric’s potential to redefine comfort and functionality in textiles. This research serves as a foundation for future advancements in textile technologies, setting the stage for the creation of fabrics that offer sustained cooling, improved comfort, and enhanced user experiences.
Disparities in Aortic Aneurysm Mortality Trends: Revealing Sex and Racial Inequalities
Authors: Azuma Masashi , Ramirez Andrew , Moser G. William , Oh Kenny J. , Kashem Mohammed Abul , Toyoda Yoshiya , Mokashi Suyog 
Published: February 2025

Background Abdominal aortic dissection or aneurysm (AAA) is a significant health concern in developed nations often underdiagnosed with poor outcomes. Despite a decline in aortic dissection and aneurysm mortality rates in the US from 1999 to 2020, reported by the CDC, this improvement disproportionately favors males and Caucasians. This study aims to elucidate these disparities. Methods Data from the CDC Wonder database from 1999 to 2020 on aortic aneurysm, including abdominal, thoracic, and thoracoabdominal aneurysms and rupture related deaths in the US were analyzed. Mortality rates were compared across sex, race, and geographic location separated by state. Mortality was normalized based on population and analyzed with linear regression models with all plots showing goodness of fit. Results Overall, the mortality gap between male and female cohorts with aortic aneurysm-related deaths widened by 0.57 per 100,000 deaths per year ( P < 0.001). Mortality between Caucasians with African American and Asian American cohorts showed reductions of 0.41 per 100,000 per year ( P < 0.001). Caucasian and male cohorts started at higher mortality rates when compared to their competitive cohorts. Conclusions Despite a reduction in mortality rates among individuals with aortic aneurysm in the US from 1999 to 2020, this decline disproportionately benefits males and Caucasians over African American and Asian populations. Although Caucasians and males had higher mortality in 1999, their decline is significantly greater. Following current trends, Caucasian and male mortalities will be lower than minority groups by 2026. Targeted interventions are needed to address these disparities effectively.
Person-centered maternity care and satisfaction with post-abortion care: A facility-based cross-sectional survey in Northern Uganda
Authors: Udho Samson , Ekung Emmanuel , Namutebi Deborah Andrinar , Aryek-kwe Josephine , Rubaihayo Abraham , Musinguzi Marvin , Kigongo Eustes , Penduka Annaloice , Nsaba Uwera Yvonne Delphine , Opio Bosco , Ogwal-Okeng Jasper 
Published: February 2025

Background: The experience of post-abortion care (PAC) is crucial to the quality of PAC services. However, there is limited literature on women’s experience with PAC, particularly the aspects of person-centered maternity care (PCMC) and satisfaction with PAC services. Objective: To examine the relationship between PCMC and satisfaction with PAC services. Design: A facility-based analytical cross-sectional study. Methods: A survey was conducted among 370 women aged 15–49 who sought PAC services at public health facilities in Lira city, Northern Uganda. Data were collected using a validated questionnaire. Data analysis included descriptive statistics, the Spearman correlation test, and multiple linear regression. Results: The mean age of study participants was 26.1 (±6.3) years. The overall PCMC median score was 21.5 (interquartile range (IQR): 11) out of 36. The median scores for the sub-scales were as follows: 6 (IQR: 6–6) for dignity and respect out of 9; 9 (IQR: 5–13) for communication and autonomy out of 18; and 8 (IQR: 6–9) for supportive care out of 9. Satisfaction with PAC services’ score ranged from 6 to 42, and the median satisfaction score was 30 (IQR range: 28–32). Bivariate analysis revealed a weak but significant correlation between the overall PCMC scale and satisfaction with PAC services ( r = 0.21, p < 0.001). Sub-scales of dignity and respect and communication and autonomy also had a weak but significant correlation with satisfaction with PAC services ( r = 0.16, p = 0.002, and r = 0.21, p < 0.001 respectively). In a linear regression model, communication and autonomy score was significantly associated with higher satisfaction with PAC score ( β = 0.10; 95% confidence interval (CI): 0.01, 0.19; p < 0.001). Conclusions: PCMC, particularly the aspects of communication between clients and providers and the promotion of clients’ autonomy, is associated with higher satisfaction with PAC services. Efforts to increase clients’ satisfaction with PAC should focus on strengthening communication between clients and providers and promoting clients’ autonomy during care.
Intention to use digital-based psychosocial counseling and its predictors among students in University of Gondar, Northwest Ethiopia, 2023: Using modified unified theory of acceptance and use of technology model
Authors: Sendek Anteneh Deje , Kelkay Jenberu Mekurianew , Wubneh Henok Dessie , Beshir Miftah Abdella , Gashu Kassahun Dessie 
Published: February 2025

Background: Psychosocial problems are widely affecting the population around the world and worsening in university students. Timely access to psychosocial counseling and support remained challenging. Hence, implementing a digital-based approach to psychosocial counseling services could potentially improve access and efficiency for students in need. However, limited evidence on the intention to use digital-based psychosocial counseling and its predictors among university students in Ethiopia. This study aimed to assess the intention to use digital-based psychosocial counseling and its predictors among students at the University of Gondar, Northwest Ethiopia. Methods: A cross-sectional study was conducted on 759 students from 28 March until 28 April 2023 at the University of Gondar, Northwest, Ethiopia. Proportional allocation was done, and the participants were selected using stratified random sampling. The median score was used as a cutoff point. The student who scores median and above on intention to use construct was considered as intended to use digital-based psychosocial counseling otherwise unintended. The interviewer-administered questionnaire, adapted from the unified theory of acceptance and use of technology model and kobo collect app, was employed to collect the data. Data were exported to SPSS 20 for descriptive analysis and Analysis of Moment and Structure version 23 for structural equation modeling analysis to assess the significance of relationships between variables using a path coefficient and a p-value of <0.05. Results: A total of 750 (98.8%) responded to complete all the questionnaires. The proportion of intention to use digital-based psychosocial counseling was 54.9%, (95% CI: 51.3%–58.5%). A structural equation modeling shows that performance expectancy (β = 0.510, p-value < 0.001), effort expectancy (β = 0.082, p-value = 0.003), and social influence (β = 0.307, p-value < 0.001) had a direct relationship with intention to use digital-based psychosocial counseling. Gender (β = 0.545, p-value < 0.001) was moderate performance expectancy. Conclusion and recommendation: The study has shown a promising intention to use digital-based psychosocial counseling among university students. Performance expectancy, effort expectancy, and social influence had a positive effect on the intention to use digital-based psychosocial counseling. Thus, the implementers need to give priority to enhancing and creating awareness for students related to how to use digital-based counseling.
Telemonitoring in Chronic Heart Failure Among the Elderly: A Rapid Review of Literature
Authors: Roaquin Lucky , Apsay Khandy Lorraine , Pangan Cauline Ruth , Hangdaan Loida , Lin Yunzhao 
Published: February 2025

Introduction Chronic heart failure (HF) is a global health issue, with telemonitoring emerging as a key strategy for elderly patient management, aligning with the Universal Health Care Law. Objective To assess the impact of telemonitoring on the quality of life, hospitalization rate, and mortality rate among elderly patients with chronic HF. Methods A rapid review of 11 studies, including randomized controlled trials, quasi-experimental, prospective, and retrospective studies from 2013 to 2023, was performed using CINAHL. The studies encompassed 14,993 elderly patients with chronic HF from hospital and homecare settings. Results The impact of telemonitoring on quality of life, hospitalization, readmission, and mortality among elderly patients with chronic HF varies widely across studies. Three studies reported quality of life improvements in the intervention group, one showed no significant change, and most studies revealed no difference in all-cause hospitalizations and readmissions between intervention and control groups. Mortality rate comparisons also showed no significant differences. Discussion The studies, conducted between 2013 and 2020 primarily in high-income regions, highlight telemonitoring's growing role in managing chronic heart failure (CHF) among elderly patients, yet its global applicability remains limited by a lack of research from Asia and Africa. While telemonitoring systems showed promise in improving patient adherence, engagement, and potentially reducing mortality, their effectiveness on quality of life, hospitalization, and readmission rates is inconsistent, likely influenced by variability in system design and patient characteristics. Limitations such as reliance on a single database, a small number of studies, and underrepresentation of mortality data further constrain the generalizability and conclusiveness of the findings. Conclusion Telemonitoring is a complex, yet promising tool for elderly CHF patient management. To enhance care quality and fulfill universal healthcare goals, policymakers and healthcare practitioners should consider these insights to create precise, effective telemonitoring strategies.
Type 2 diabetes in stroke patients: Impact on outcomes, recurrence, resource use, and costs in France
Authors: Sibon Igor , Mohammedi Kamel , Quignot Nadia , Read Stephanie , Kapnang Raissa , Khachatryan Artak , Kikuchi Kazue , Ren Hongye , Massien Christine , Vigié Lucile , Larsen Sara , Fauchier Laurent 
Published: February 2025

Introduction: Contemporary estimates of the impact of type 2 diabetes (T2D) on stroke outcomes are important for care planning and resource allocation. This retrospective cohort study compared the incidence of stroke and subsequent clinical and economic outcomes following stroke among people with and without T2D. Patients and methods: Data were extracted from a subset of the French Système National des Données de Santé database. Stroke incidence as well as post-stroke clinical outcomes, healthcare resource utilization (HCRU), use of stroke preventative treatments, and costs were compared among people with and without T2D. Results: The study included 10,906 patients hospitalized for stroke including 2141 (19.6%) people with T2D. Age-standardized stroke incidence rates were 3.3 (95% confidence interval [CI] 3.1; 3.6) per 1000 person-years and 2.2 (2.1; 2.3) in people with and without T2D, respectively. Patients with T2D had significantly higher risk of stroke recurrence (adjusted hazard ratio [HR] 1.14, 95% CI: 1.01; 1.30) and mortality (HR 1.16, 95% CI: 1.08; 1.25) than patients without T2D. The proportion of patients with T2D treated with statins decreased from 27.3% pre-stroke to 20.6% post-stroke but remained relatively stable among patients without T2D (from 13.4% to 13.1%). The mean healthcare costs in the 12 months following stroke were higher among patients with T2D than those without (€22,635 vs €18,629). Discussion and Conclusion: The incidence and clinical and economic burden of stroke is considerably higher among people with T2D. Further efforts are needed to reduce this disparity.
Machine learning uncovers novel sex-specific dementia biomarkers linked to autism and eye diseases
Authors: Khan Ayub , Ghasemi Ali R , Ingram Krista K , Ay Ahmet 
Published: February 2025

Background Recently, microRNAs (miRNAs) have attracted significant interest as predictive biomarkers for various types of dementia, including Alzheimer's disease (AD), vascular dementia (VaD), dementia with Lewy bodies (DLB), normal pressure hydrocephalus (NPH), and mild cognitive impairment (MCI). Machine learning (ML) methods enable the integration of miRNAs into highly accurate predictive models of dementia. Objective To investigate the differential expression of miRNAs across dementia subtypes compared to normal controls (NC) and analyze their enriched biological and disease pathways. Additionally, to evaluate the use of these miRNAs in binary and multiclass ML models for dementia prediction in both overall and sex-specific datasets. Methods Using data comprising 1685 Japanese individuals (GSE120584 and GSE167559), we performed differential expression analysis to identify miRNAs associated with five dementia groups in both overall and sex-specific datasets. Pathway enrichment analyses were conducted to further analyze these miRNAs. ML classifiers were used to create predictive models of dementia. Results We identified novel differentially expressed miRNA biomarkers distinguishing NC from five dementia subtypes. Incorporating these miRNAs into ML classifiers resulted in up to a 27% improvement in dementia risk prediction. Pathway analysis highlighted neuronal and eye disease pathways associated with dementia risk. Sex-specific analyses revealed unique biomarkers for males and females, with miR-128-1-5 as a protective factor for males in AD, VaD, and DLB, and miR-4488 as a risk factor for female AD, highlighting distinct pathways and potential therapeutic targets for each sex. Conclusions Our findings support existing dementia etiology research and introduce new potential and sex-specific miRNA biomarkers.
Targeting NINJ1-mediated cell rupture to treat inflammatory diseases
Authors: Hur Claire Ju-Eun , Steinberg Benjamin Ethan 
Published: February 2025

Abstract
Cell death can terminate in plasma membrane rupture to release potent pro-inflammatory intracellular contents thereby contributing to inflammatory diseases. Cell rupture is an active process, mediated by the membrane protein ninjurin-1 (NINJ1) in pyroptosis, post-apoptosis lysis, ferroptosis, and forms of necrosis. Once activated, NINJ1 clusters into large oligomers within the membrane to initiate cellular lysis. Recent preclinical studies have demonstrated that inhibiting NINJ1 is a new strategy for treating immune-mediated diseases. Indeed, both small molecule inhibitors and neutralizing antibodies can target NINJ1 clustering to preserve plasma membrane integrity and mitigate disease pathogenesis. In this Perspective, we provide a summary of the current state of knowledge and recent developments in targeting cellular integrity during cell death through NINJ1 inhibition to treat inflammatory disease, with a focus on liver injury. As these NINJ1-mediated cell death pathways are pivotal in maintaining health and contribute to disease pathogenesis when dysregulated, the studies discussed within have broad implications across the immunologic basis of molecular medicine.
Commentary: Tolvaptan for Autosomal Dominant Polycystic Kidney Disease (ADPKD) - an update
Authors: Gittus Matt , Haley Helen , Harris Tess , Borrows Sarah , Padmanabhan Neal , Gale Danny , Simms Roslyn , Williams Terri , Acquaye Aaron , Wong Alisa , Chan Melanie , Lee Eduardo , Ong Albert CM 
Published: February 2025

Abstract
Autosomal Dominant Polycystic Kidney Disease (ADPKD) affects up to 70 000 people in the UK and the most common inherited cause of end-stage kidney disease (ESKD). It is generally a late-onset multisystem disorder characterised by bilateral kidney cysts, liver cysts and an increased risk of intracranial aneurysms. Approximately 50% of people with ADPKD reach ESKD by age 60. Disease-associated pain, discomfort, fatigue, emotional distress and, impaired mobility can impact health-related quality of life. The approval of tolvaptan, a vasopressin V2 receptor antagonist, has greatly advanced the care for people with ADPKD, shifting the focus from general chronic kidney disease management to targeted therapeutic approaches. While guidance from NICE and SMC provides a foundational framework, this is not clear or comprehensive enough to offer practical guidance for healthcare professionals in real-world settings. This commentary expands on the previous United Kingdom Kidney Association (UKKA) commentary in 2016 with an updated evidence base, the incorporation of real-world data and expert opinion to provide practical guidance to healthcare professionals. Through co-development with people affected by ADPKD, it now incorporates valuable patient perspectives and offers practical recommendations for the UK kidney community seeking to harmonise the quality of care of all people with ADPKD.
Comprehensive predictors of drug-resistant epilepsy in MELAS: clinical, EEG, imaging, and biochemical factors
Authors: Gao Rui , Gu Lihua , Zuo Wenchao , Wang Pan 
Published: February 2025

Abstract

Background
Seizures are a common but often overlooked manifestation of MELAS. This study aimed to describe the characteristics of seizures in MELAS and to analyze the clinical, electroencephalographic, imaging, and biochemical factors associated with drug-resistant epilepsy.

Methods
A single-center retrospective study was conducted to investigate the clinical characteristics of seizures in MELAS patients. The study collected data on clinical features, muscle biopsy results, genetic testing, seizure symptoms, electroencephalography (EEG), neuroimaging findings, cerebrospinal fluid and blood biochemistry, and the modified Rankin Scale (mRS). We also investigated the correlation between seizure frequency and mRS scores. In addition, we analyzed the risk factors for drug-resistant epilepsy in MELAS.

Results
A total of 37 patients with confirmed MELAS (24 males and 13 females) were included in the study. All patients experienced seizures, with an onset age ranging from 14 to 53 years and a mean of 32 years. These MELAS patients experienced a variety of seizure types, with generalized seizures being the most common. EEG findings revealed background rhythm abnormalities in all patients, and epileptiform discharges were observed in 37.8% of patients during the interictal phase. Status epilepticus (OR 16.499; 95% CI, 1.615–168.557; P = 0.018) and elevated resting serum lactate levels (OR 8.594; 95% CI, 1.342–59.733; P = 0.024) were identified as independent risk factors for drug-resistant epilepsy. In addition, changes in the seizure frequency at the last follow-up compared to baseline were positively correlated with the mRS score. (r = 0.533, p < 0.001).

Conclusion
Status epilepticus and elevated resting serum lactate levels were predictive of the development of drug-resistant epilepsy in MELAS. Poor seizure control was significantly associated with increased clinical disability. Early identification of high-risk patients for drug-resistant epilepsy could facilitate the development of more effective treatment plans.
Thriving at work as a mediator between nurses’ structural empowerment and job performance, work-personal life benefits, stress symptoms and turnover intentions: a cross-sectional study
Authors: Engström Maria , Björkman Annica , Silén Marit , Wahlberg Anna Carin , Skytt Bernice 
Published: February 2025

Abstract

Background
Nurses work in a knowledge-intensive sector with high demands for lifelong learning. Thriving is a positive psychological state, including a sense of mutual learning and vitality at work. Research on thriving, its antecedents and outcomes is called for. The study aim was to examine thriving as a mediator in the relationships between telephone nurses’ structural empowerment and the outcomes work-personal life benefits, job performance, work-related stress symptoms and turnover intentions, as well as to psychometrically test the Thriving Scale (Swedish version).

Methods
Questionnaire data, a national sample of 409 Swedish telephone nurses, were collected, and relationships were examined using multiple regression analyses with PROCESS macro. Factorial validity of the Thriving Scale was tested using confirmative factor analyses.

Results
There were statistically significant relationships between structural empowerment and the outcomes (work-personal life benefits, job performance, stress symptoms, turnover intentions), and these relationships were mediated by thriving. The Thriving Scale showed good internal consistency, and an acceptable to borderline mediocre fit for factorial validity. Thirty-two percent reported turnover intentions.

Conclusions
Good access to structural empowerment increases nurses’ thriving, which in turn improves work-personal life benefits, job performance, and decreases stress symptoms and turnover intentions. Managers should strive to improve nurses’ thriving at work, emphasizing good access to empowering structures.