bluuebunny/crossref_metadata_2025_split huggingface dataset:
Human mesenchymal stem cells in synovial fluid increase in the knee with degenerated cartilage and osteoarthritis
Authors: Sekiya Ichiro , Ojima Miyoko , Suzuki Shiro , Yamaga Mika , Horie Masafumi , Koga Hideyuki , Tsuji Kunikazu , Miyaguchi Ken , Ogishima Soichi , Tanaka Hiroshi , Muneta Takeshi 
Published: December 2011

AbstractWe investigated whether mesenchymal stem cells (MSCs) in synovial fluid (SF) increased in the knee with degenerated cartilage and osteoarthritis. SF was obtained from the knee joints of 22 patients with anterior cruciate ligament (ACL) injury during ACL reconstruction, and cartilage degeneration was evaluated arthroscopically. SF was also obtained from the knee joints of 6 healthy volunteers, 20 patients with mild osteoarthritis, and 26 patients with severe osteoarthritis, in which the grading was evaluated radiographically. The cell component in the SF was cultured for analyses. Synovium (SYN) and bone marrow (BM) were also harvested during total knee arthroplasties. The MSC number in SF was correlated with the cartilage degeneration score evaluated by arthroscopy. The MSC number in the SF was hardly noticed in normal volunteers, but it increased in accordance with the grading of osteoarthritis. Though no significant differences were observed regarding surface epitopes, or differentiation potentials, the morphology and gene profiles in SF MSCs were more similar to those in SYN MSCs than in BM MSCs. We listed 20 genes which were expressed higher in both SYN MSCs and SF MSCs than in BM MSCs, and 3 genes were confirmed by quantitative RT‐PCR. MSCs in SF increased along with degenerated cartilage and osteoarthritis. © 2011 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 30:943–949, 2012
Comorbidity among depression, conduct disorder, and drug use from adolescence to young adulthood: Examining the role of violence exposures
Authors: Cerdá Magdalena , Tracy Melissa , Sánchez Brisa N. , Galea Sandro 
Published: December 2011

AbstractWe assessed relations among depression, conduct disorder, and drug use from adolescence to young adulthood, and evaluated whether exposure to violence contributed to disorder co‐occurrence. We used data from the Project on Human Development in Chicago Neighborhoods. Respondents were 12–15 years old in 1995–1997 (N = 1,517), and were reinterviewed in 1997–2000 (n = 1,315), and 2000–2002 (n = 1,210). We examined exposure to violence at ages 12–15 and 14–17, and depression, conduct disorder, and drug use at ages 14–17 and 17–20. Multivariate transition models revealed an association between prior conduct disorder and drug use, as well as a relationship between prior depression and conduct disorder. Adolescent exposure to violence was associated with higher odds of conduct disorder and drug use but not depression. Comorbid relations between conduct disorder and drug use were independent of prior exposure to violence. Although preventing adolescent exposure to violence may reduce the risk of conduct disorder and drug use by young adulthood, future research needs to investigate alternative determinants of sequential comorbidity among depression, conduct disorder, and drug use in adolescence and young adulthood.
Laryngeal electromyography for prognosis of vocal fold palsy: A Meta‐Analysis
Authors: Rickert Scott M. , Childs Lesley F. , Carey Bridget T. , Murry Thomas , Sulica Lucian 
Published: December 2011

AbstractObjectives/Hypothesis:To analyze existing evidence regarding utility of laryngeal electromyography (LEMG) for prognosis in cases of vocal fold palsy (VFP).Study Design:Meta‐analysis of studies reporting LEMG results and clinical outcomes in 503 patients with of VFP identified by literature search.Methods:Studies were identified by literature search. Method of diagnosis, interval to LEMG, criteria for prognostication, and outcome were assessed. Criteria for prognosis were standardized to the extent possible across all studies, and studies were checked for consistency in outcome measures and assessments. Pooled data were subjected to statistical analysis.Results:A total of 296/503 patients (58.8%) had findings predictive with poor prognosis, whereas 207/503 (41.2%) had findings of recovery. According to laryngoscopic examination, 269/296 patients with predicted poor recovery had poor recovery (positive predictive value = 90.9%), whereas 27/296 (9.1%) had good recovery. In patients with findings consistent with recovery, 115/207 (negative predictive value = 55.6%) noted return of motion, whereas 88/207 (44.4%) did not. The odds ratio was 11.56 with 95% confidence interval of 7.10‐18.81.Conclusions:LEMG is a good predictor of poor recovery in patients with VFP and is clinically useful in identifying candidates for early definitive intervention.
Gluten sensitivity in Meniere's disease
Authors: Di Berardino Federica , Cesarani Antonio 
Published: December 2011

AbstractObjectives/Hypothesis:Wheat is one of the most common food allergens found in patients with Meniere's disease (MD). Gluten from wheat has been identified to have a etiopathogenetic role in celiac disease, IgE hypersensitivity to wheat disease, and recently to gluten sensitivity. The aim of this study was to verify the incidence of gliadin prick test response in patients affected by MD.Study Design:Prospective individual case‐control study.Methods:There were 58 adult patients with definite MD, 25 healthy volunteers, and 25 patients with grass pollen rhinoconjunctivitis tested with skin prick test to gliadin.Results:A total of 33 MD patients (56.9%) proved to be sensitive to gliadin, eight of whom were positive to prick test after 20 minutes, 13 after 6 hours, 11 after 12 hours, and one after 24 hours.Conclusions:This is the first report of gliadin skin test response in MD. Further studies are needed to define the relationship between immune response to wheat proteins and MD symptoms.
Wet air as an alternative to traditional water irrigation during caloric vestibular testing
Authors: Gudziol Hilmar , Koch Carolin , Bitter Thomas , Guntinas‐Lichius Orlando 
Published: December 2011

AbstractObjectives/Hypothesis:To evaluate whether caloric vestibular testing by wet air (WAI) is better than by dry air (DAI) in comparison to the gold standard using water (WAT).Study Design:Prospective study, comparison with reference standard.Methods:Fifty volunteers with normal ear and balance function were enrolled in a prospective study. After side‐specific warm and cold DAI, WAI, and WAT experimental nystagmuses were recorded using video‐oculography. Peak slow nystagmus phase velocity (SPV) data at test culmination and the subjective tolerance of the methods were analyzed by visual analog scale.Results:The three methods differed significantly with respect to warm versus cold stimulation and stimulus side, with one exception. In the case of cold stimulation on the left side, SPV values did not differ between DAI and WAI. The intraclass correlation coefficients (ICCs) of WAT versus WAI were indicative of a medium to high agreement with the SPV data for all four individual irrigations. The ICCs of the WAT/DAI comparison were usually smaller. Generally, smaller individual differences were shown in Bland‐Altman plots comparing WAI and WAT than plots comparing DAI and WAT. WAI had better subjective tolerability than WAT.Conclusions:WAI is an alternative caloric test method for anxious subjects oversensitive to WAT and probably for patients with suspected pathological ear canal and tympanic membrane findings.
Comparison of conventional continuous positive airway pressure to continuous positive airway pressure titration performed with sleep endoscopy
Authors: Civelek Senol , Emre Ismet Emrah , Dizdar Denizhan , Cuhadaroglu Caglar , Eksioglu Birsen Karaci , Eraslan Algın Kayar , Turgut Suat 
Published: December 2011

AbstractObjectives/Hypothesis:To evaluate the effect and obtain a pressure value of continuous positive airway pressure (CPAP) under direct visualization using drug‐induced sleep endoscopy (DISE) and compare the pressure values with values obtained using conventional CPAP.Study Design:Prospective, double‐blinded, cohort study.Methods:Sixteen patients with obstructive sleep apnea syndrome (OSAS) were included in the study. Each patient underwent polysomnographic evaluation. After diagnosis of OSAS, patients underwent conventional CPAP titration. Patients were then taken to the operating theatre and put under sedation, where CPAP titration with nasendoscopy was performed (DISE CPAP).Results:There were no statistically significant differences between the two techniques regarding pressure levels that decreased apneas in conventional CPAP and provided sufficient opening during DISE CPAP.Conclusions:Results with conventional CPAP titration and endoscopy‐assisted CPAP titration showed no statistically significant difference. Endoscopy‐assisted CPAP is a cheaper and less time consuming alternative to conventional CPAP and has similar results.
Virtual temporal bone dissection system: OSU virtual temporal bone system
Authors: Wiet Gregory J. , Stredney Don , Kerwin Thomas , Hittle Bradley , Fernandez Soledad A. , Abdel‐Rasoul Mahmoud , Welling D. Bradley 
Published: December 2011

AbstractObjectives/Hypothesis:The objective of this project was to develop a virtual temporal bone dissection system that would provide an enhanced educational experience for the training of otologic surgeons.Study Design:A randomized, controlled, multi‐institutional, single‐blinded validation study.Methods:The project encompassed four areas of emphasis: structural data acquisition, integration of the system, dissemination of the system, and validation.Results:Structural acquisition was performed on multiple imaging platforms. Integration achieved a cost‐effective system. Dissemination was achieved on different levels including casual interest, downloading of software, and full involvement in development and validation studies. A validation study was performed at eight different training institutions across the country using a two‐arm randomized trial where study subjects were randomized to a 2‐week practice session using either the virtual temporal bone or standard cadaveric temporal bones. Eighty subjects were enrolled and randomized to one of the two treatment arms; 65 completed the study. There was no difference between the two groups using a blinded rating tool to assess performance after training.Conclusions:A virtual temporal bone dissection system has been developed and compared to cadaveric temporal bones for practice using a multicenter trial. There was no statistical difference between practice on the current simulator compared to practice on human cadaveric temporal bones. Further refinements in structural acquisition and interface design have been identified, which can be implemented prior to full incorporation into training programs and used for objective skills assessment.
Founders' syndrome in women's nonprofit organizations: Implications for practice and organizational life
Authors: English Leona , Peters Nancy 
Published: December 2011

AbstractThis qualitative study examines the impact of “founders' syndrome” in ten feminist nonprofit organizations, giving attention to the ways in which original members and organizers (founders) retain control and set the agenda of these organizations beyond their official terms of office. In these community‐based organizations, founders' syndrome provides stability, but it also affects the ability of younger members to contribute and influence organizational direction. Implications for practice are drawn from the study's results.
Determining person–organization fit for healthcare CEOs: How executive equity sensitivity relates to nonprofit and for‐profit sector selection
Authors: Sass Mary D. , Liao‐Troth Matthew A. , Wonder Bruce D. 
Published: December 2011

AbstractThis article empirically examines the relationship between the trait of equity sensitivity and employment sector (for‐profit, public, and nonprofit) for senior executives. By controlling for industry (healthcare), we show a relationship between this trait and employment sector in both a single‐state survey and a multistate survey. Findings indicate that benevolents have a propensity to pursue nonprofit positions whereas entitleds are likely to gravitate toward for‐profit positions. Implications for job seekers, employers, and academics are provided.
Antiangiogenic metronomic therapy for children with recurrent embryonal brain tumors
Authors: Peyrl Andreas , Chocholous Monika , Kieran Mark W. , Azizi Amedeo A. , Prucker Christina , Czech Thomas , Dieckmann Karin , Schmook Maria‐Theresa , Haberler Christine , Leiss Ulrike , Slavc Irene 
Published: December 2011

AbstractBackgroundMedian survival time of recurrent embryonal brain tumors is short regardless of salvage chemotherapy used. An evolving alternative approach to conventional chemotherapy is to target neovascularization by interfering with tumor angiogenesis at various levels.ProcedureFrom November 2006 to December 2010, 16 patients (median age: 9 years) with recurrent (9 first, 7 multiple) embryonal brain tumors were treated with an antiangiogenic multidrug combination regimen (bevacizumab, thalidomide, celecoxib, fenofibrate, etoposide, and cyclophophamide) and additional intraventricular therapy (etoposide and liposomal cytarabine).ResultsAt a median of 33 months, 10/16 patients are alive. 4/4 patients with CNS primitive neuroectodermal tumors (CNS PNET) and 1/7 patients with medulloblastoma (MB) died of tumor progression during the first year. Another patient with MB died of an accident after 23 months, the remaining five patients with MB are alive for 12, 33, 33, 37, and 58 months. For the seven patients with MB, both overall survival (OS) and event free survival (EFS) after 6 months was 100%, after 12 months 85.7 ± 13%, and after 24 months 68.6 ± 19%. In contrast, for patients with CNS PNET, both OS and EFS after 6 months was 75.0 ± 22% and 0.0% and all patients had died by 12 months. Low‐dose oral etoposide and cyclophosphamide was reduced after a median of 2 months and discontinued after a median of 11 months. Toxicities were manageable and therapy was generally well tolerated.ConclusionOur results suggest that the chosen antiangiogenic drug combination is particularly beneficial for patients with MB and warrants further investigation. Pediatr Blood Cancer 2012;59:511–517. © 2011 Wiley Periodicals, Inc.
Thermal Decomposition Study of HNIW by Synchrotron Photoionization Mass Spectrometry
Authors: Dong Linmao , Li Xiaodong , Yang Rongjie 
Published: December 2011

AbstractThermal decomposition of hexanitrohexaazaisowurtzitane (HNIW) was investigated through tuneable vacuum ultraviolet photoionization with molecular‐beam sampling mass spectrometry (MBMS). According to photoionization efficiency (PIE) spectroscopic results, the initial decomposition products of HNIW were identified including HCN, CO, NO, HNCO, N2O, CO2 (a little), NO2, C2H2N2, C3H3N3, C4H3N3, C3H4N4, C5H4N4, C5H5N5 and C6H6N6. The possible ionization energies of C2H2N2, C4H3N3, C3H4N4 and C6H6N6 were analyzed on basis of the PIE spectra. The data were compared with those of thermogravimetry‐mass spectrometry (TG‐MS) and thermogravimetry‐Fourier transform‐infrared spectroscopy (TG‐FT‐IR). The kinetic parameters for the formation of HNCO, HCN and CO2 were calculated from the current curves of species by TG‐FT‐IR spectroscopy, typically the apparent activation energy (Ea) and prefactor (A) for HNCO were Ea=161.3 ± 2.5 kJ mol−1 and A=38.9 ± 0.6 s−1 with an optimal mechanism function f(α)=(1−α). Global thermal decomposition reaction and Arrhenius equation of HNIW were suggested at the end.
Ground‐state structure of KNbO3/KTaO3 superlattices: Array of nearly independent ferroelectrically ordered planes
Authors: Lebedev Alexander I. 
Published: December 2011

AbstractPhonon spectra of the paraelectric phase, structure and distribution of polarization in the polar ground state, and energies of ferroelectrically and antiferroelectrically ordered phases were calculated for stress‐free (KNbO3)1(KTaO3)n superlattices (n = 1–7) from first principles within the density‐functional theory. Quasi‐two‐dimensional ferroelectric state with the polarization localized in the KNbO3 layer was revealed to be the ground state for the superlattices with n ≥ 2. The interaction between these polarized layers decreases exponentially with increasing the interlayer distance, and the ground‐state structure transforms to an array of nearly independent ferroelectrically ordered planes at large n.
Acetone and 2‐butanone creation associated with biological and chemical remediation of environmental contamination
Authors: Fowler Troy , Thompson Bruce , Mueller Jim 
Published: December 2011

AbstractRemediating environmental contamination by either biological or chemical methods typically results in the generation of temporary chemical intermediates as part of the process. These intermediate compounds may be related to either contaminant degradation pathways or reactions generated from the amendment itself. This article summarizes previously researched pathways and representative case studies discussing the authors' experience in generating relatively high concentrations of acetone and 2‐butanone (also referred to as methyl ethyl ketone [MEK]) during both biological and chemical treatments. Experience shows that even relatively high concentrations of acetone and MEK intermediates are quickly attenuated and prove not to be a hazard outside of the treatment area. © 2011 Wiley Periodicals, Inc.
Insufficient source area remediation results in the rebound of TCE breakdown products in groundwater
Authors: Dickson James R. , Stenson Rob 
Published: December 2011

AbstractIn the early 1990s, a soil removal action was completed at a former disposal pit site located in southern Michigan. This action removed waste oil, cutting oil, and chlorinated solvents from the unsaturated zone. To contain groundwater contaminant migration at the site, a groundwater pump‐and‐treat system comprised of two extraction wells operating at a combined flow of 50 gallons per minute, carbon treatment, and a permitted effluent discharge was designed, installed, and operated for over 10 years. Groundwater monitoring for natural attenuation parameters and contaminant attenuation modeling demonstrated natural attenuation of the contaminant plume was adequate to attain site closure. As a result of incomplete contaminant source removal, a rebound of contaminants above the levels established in the remedial action plan (RAP) has occurred in the years following system shutdown and site closure. Groundwater concentrations have raised concerns regarding potential indoor air quality at adjacent residential properties constructed in the past 9 to 10 years. The only remedial option available in the original RAP is to resume groundwater pump‐and‐treat. To remediate the source area, an alternate remediation strategy using an ozone sparge system was developed. The ozone sparge remediation strategy addresses the residual saturated zone contaminants beneath the former disposal pit and reestablishes site closure requirements without resumption of the pump‐and‐treat system. A pilot study was completed successfully; and the final system design was subsequently approved by the Michigan Department of Environmental Quality. The system was installed and began operations in July 2010. As of the January 2011 monitoring event, the system has shown dramatic improvement in site contaminant concentrations. The system will continue to operate until monitoring results indicate that complete treatment has been obtained. The site will have achieved the RAP objectives when the system has been shut down and meets groundwater residential criteria for four consecutive quarters. © 2011 Wiley Periodicals, Inc.
Pilot scale testing composite swellable organosilica nanoscale zero‐valent iron—Iron‐Osorb®—for in situ remediation of trichloroethylene
Authors: Edmiston Paul L. , Osborne Christine , Reinbold Karl P. , Pickett Deanna C. , Underwood Laura A. 
Published: December 2011

AbstractIron‐Osorb® is a solid composite material of swellable organosilica with embedded nanoscale zero‐valent iron that was formulated to extract and dechlorinate solvents in groundwater. The unique feature of the highly porous organosilica is its strong affinity for chlorinated solvents, such as trichloroethylene (TCE), while being impervious to dissolved solids. The swellable matrix is able to release ethane after dechlorination and return to the initial state. Iron‐Osorb® was determined to be highly effective in reducing TCE concentrations in bench‐scale experiments. The material was tested in a series of three pilot scale tests for in situ remediation of TCE in conjunction with the Ohio Environmental Protection Agency at a site in central Ohio. Results of these tests indicate that TCE levels were reduced for a period of time after injection, then leveled out or bounced back, presumably due to depletion of zero‐valent iron. Use of tracer materials and soil corings indicate that Iron‐Osorb® traveled distances of at least 20 feet from the injection point during soil augmentation. The material appears to remain in place once the injection fluid is diluted into the surrounding groundwater. Overall, the technology is promising as a remediation method to treat dilute plumes or create diffuse permeable reactive barriers. Keys to future implementation include developing injection mechanisms that optimize soil distribution of the material and making the system long‐lasting to allow for continual treatment of contaminants emanating from the soil matrix. © 2011 Wiley Periodicals, Inc.
A study on hot spot detection possibility in simulated oil‐filled‐type transformer tank by using ultrasonic methods
Authors: Chen Fa‐Chung , Tang Zhi‐Cheng 
Published: December 2011

AbstractFailure of oil‐filled‐type (OFT) power transformers usually results in very big losses comprising the loss of the transformer itself as well as production loss in industry. Most of the energy lost in OFT transformers, induced by faults, will become heat at a location close to the fault, which then becomes a hot spot. The detection of hot spots in OFT transformers can be an effective way for transformer fault location and diagnosis. As the OFT transformer enclosure is completely sealed and is opaque, to date there is no effective way to find out hot spots in them. It is known that ultrasonic energy can be transmitted into the sealed transformer enclosure which is filled with the fluid, and ultrasonic waves can be affected by the temperature of the materials they propagate through; so the ultrasonic method can be a possible method for hot spot detection. In this paper, we describe a study on the possibility of developing a method to detect hot spots in an environment filled with a fluid, simulating a transformer. Trails using a different times‐of‐flight (TOFs) evaluation techniques and attenuation measurement of the ultrasonic energy propagated were carried out, which showed encouraging results for locating the hot spot as well as measuring the hot spot temperature in fluids; we also discuss the possibility of applying these results to the diagnosis of OFT transformers eventually. © 2011 Institute of Electrical Engineers of Japan. Published by John Wiley & Sons, Inc.