bluuebunny/crossref_metadata_2025_split huggingface dataset:
Upgrading the Compressor Stage of the CAT250TJ Micro Gas Turbine Engine
Authors: van Eck Hano , van der Spuy Sybrand Johannes 
Published: June 2024

AbstractDue to their simplicity and relative ease of manufacture, single-stage centrifugal and mixed flow micro gas turbine (MGT) engines are preferred in thrust-based remotely piloted aerial vehicles. A single-stage mixed-flow compressor upgrade for the 200 N CAT250TJ MGT engine is numerically evaluated and presented. An in-house developed mean line application and commercial CFD software is used for the design and performance evaluation of the proposed upgrade configurations. The CAT250TJ – Gen1 engine features a single-stage centrifugal compressor, annular combustor, and single stage axial turbine. Apart from an upgraded impeller, a new crossover diffuser configuration is introduced to replace the wedge-type, straight outlet diffuser configuration of the Gen1 engine. The new single vane crossover diffuser configuration provides a design point total-to-total efficiency and pressure ratio increase of 8.3% and 12.1%, respectively. A disadvantage of a single-vaned crossover diffuser compared to legacy diffusers is a narrower operating range. To alleviate this issue, various combinations of tandem and splitter vane crossover diffuser configurations are proposed. These provide an enhanced operating range, comparable with the operating range displayed by the Gen1 configuration. A turbine power matching analysis is additionally completed to ensure proper compressor integration. Gas turbine cycle software is used to evaluate the on-engine performance of the upgraded compressor configurations. It is shown that the new baseline, single vane crossover diffuser configuration provides a 10.74% increase in design point static thrust.
The Transformed MG-Extended Exponential Distribution: Properties and Applications
Authors: Menberu Addisalem Assaye , Goshu Ayele Taye 
Published: June 2024

AbstractOur research paper introduces a newly developed probability distribution called the transformed MG-extended exponential (TMGEE) distribution. This distribution is derived from the exponential distribution using the modified Frechet approach, but it has a more adaptable hazard function and unique features that we have explained in detail. We conducted simulation studies using two methods: rejection sampling and inverse transform sampling, to produce summaries and show distributional properties. Moreover, we applied the TMGEE distribution to three real datasets from the health area to demonstrate its applicability. We used the maximum likelihood estimation technique to estimate the distribution’s parameters. Our results indicate that the TMGEE distribution provides a better fit for the three sets of data as compared to nine other commonly used probability distributions, including Weibull, exponential, and lognormal distributions.
Design issues concerning circular economy assessment methods at the product level: a comparative analysis through a case study of a mobile tiny house
Authors: Ruiz-Pastor Laura , Altavilla Stefania , Borgianni Yuri 
Published: June 2024

Abstract
Sustainability evaluations are increasingly relevant in the design of products. Within sustainability-related frameworks, circular economy (CE) has gained attention in the last few years, and this has vastly affected design, leading, for example, to design for circularity. This article deals with the wide range of product-level CE assessment tools, out of which some are applied to a case study from the building sector, namely a tiny house made with hemp bricks. Attention was specifically paid to those methods through which a single circularity indicator could be extrapolated. Overall, the objective of this work is to study the convergence of existing CE assessment methods in providing consistent circularity performances. The results show similarities in the overall circularity scores despite differences in the variables used to achieve that final score. Thus, despite the lack of standard methods, the results suggest that many of these tools are sufficiently interchangeable, also in consideration of consistent indications to improve the circularity of the tiny house. This means that consistent inputs are provided to anyone willing to redesign the tiny house with the objective of making it more circular irrespective of the assessment tool used.
Design and analysis of a negative pressure wall-climbing robot with an omnidirectional characteristic for cylindrical wall
Authors: Yuan Chunyang , Chang Yong , Song Yifeng , Lin Song , Jing Fengren 
Published: June 2024

AbstractA negative pressure wall-climbing robot is a special robot for climbing vertical walls, which is widely used in construction, petrochemicals, nuclear energy, shipbuilding, and other industries. The mobility and adhesion of the wheel-track wall-climbing robot with steering-straight mode are significantly decreased on the cylindrical wall, especially during steering. The reason is that the suction chamber may separate from the wall and the required driving force for movement increases, during steering. In this paper, a negative pressure wall-climbing robot with omnidirectional movement mode is developed. By introducing a compliant adjusting suction mechanism and omni-belt wheels, an omnidirectional movement mode is formed instead of the steering-straight mode, and the performances of adhesion and mobility are improved. We establish the safety adhesion model for the robot on a cylindrical wall and obtain the safety adhesion forces. We designed and manufactured an experimental prototype based on the analysis. Experiments showed that the robot has the ability of full maneuverability in cylindrical walls.
Seasonal and Interannual Salish Sea Inflow Origins Using Lagrangian Tracking
Authors: Beutel Becca , Allen Susan E. 
Published: June 2024

AbstractThe Salish Sea is a semi‐enclosed sea between Vancouver Island and the coast of British Columbia and Washington State, invaluable from both an economic and ecologic perspective. Here we explore the contribution of Pacific water masses to the flow through Juan de Fuca Strait (JdF), the Salish Sea's primary connection to the Pacific Ocean. Quantitative Lagrangian particle tracking within Ariane, an offline Lagrangian tool capable of volume transport calculations, was applied to two numerical ocean models to track the paths and physical properties of water parcels before entering JdF (CIOPS) and within the Salish Sea (SalishSeaCast). During summer upwelling, flow from the north shelf and offshore dominate Pacific inflow, while during winter downwelling, flow from the south shelf and surface flow from the Columbia River plume are the dominant Pacific sources. A weaker and less consistent estuarine flow regime in the winter leads to less Pacific inflow overall and a smaller percentage of said inflow reaching the Salish Sea's inner basins than in the summer. Nevertheless, it was found that winter dynamics are a large driver of interannual variability. This analysis extends the knowledge on the dynamics of Pacific inflow to the Salish Sea and highlights the importance of winter inflow to interannual variability.
The Vigil Magnetometer for Operational Space Weather Services From the Sun‐Earth L5 Point
Authors: Eastwood J. P. , Brown P. , Magnes W. , Carr C. M. , Agu M. , Baughen R. , Berghofer G. , Hodgkins J. , Jernej I. , Möstl C. , Oddy T. , Strickland A. , Vitkova A. 
Published: June 2024

AbstractSevere space weather has the potential to cause significant socio‐economic impact and it is widely accepted that mitigating this risk requires more comprehensive observations of the Sun and heliosphere, enabling more accurate forecasting of significant events with longer lead‐times. In this context, it is now recognized that observations from the L5 Sun‐Earth Lagrange point (both remote and in situ) would offer considerable improvements in our ability to monitor and forecast space weather. Remote sensing from L5 allows for the observation of solar features earlier than at L1, providing early monitoring of active region development, as well as tracking of interplanetary coronal mass ejections through the inner heliosphere. In situ measurements at L5 characterize the solar wind's geoeffectiveness (particularly stream interaction regions), and can also be ingested into heliospheric models, improving their performance. The Vigil space weather mission is part of the ESA Space Safety Program and will provide a real‐time data stream for space weather services from L5 following its anticipated launch in the early 2030s. The interplanetary magnetic field is a key observational parameter, and here we describe the development of the Vigil magnetometer instrument for operational space weather monitoring at the L5 point. We summarize the baseline instrument capabilities, demonstrating how heritage from science missions has been leveraged to develop a low‐risk, high‐heritage instrument concept.
X‑chromosome loss rescues Sertoli cell maturation and spermatogenesis in Klinefelter syndrome
Authors: Winge Sofia B. , Skakkebaek Niels E. , Aksglaede Lise , Saritaş Gülizar , Rajpert-De Meyts Ewa , Goossens Ellen , Juul Anders , Almstrup Kristian 
Published: June 2024

AbstractKlinefelter syndrome (47,XXY) causes infertility with a testicular histology comprising two types of Sertoli cell-only tubules, representing mature and immature-like Sertoli cells, and occasionally focal spermatogenesis. Here, we show that the immature-like Sertoli cells highly expressed XIST and had two X-chromosomes, while the mature Sertoli cells lacked XIST expression and had only one X-chromosome. Sertoli cells supporting focal spermatogenesis also lacked XIST expression and the additional X-chromosome, while the spermatogonia expressed XIST despite having only one X-chromosome. XIST was expressed in Sertoli cells until puberty, where a gradual loss was observed. Our results suggest that a micro-mosaic loss of the additional X-chromosome is needed for Sertoli cells to mature and to allow focal spermatogenesis.
Enantioselective synthesis of chiral amides by carbene insertion into amide N–H bond
Authors: Zhang Xuan-Ge , Yang Zhi-Chun , Pan Jia-Bin , Liu Xiao-Hua , Zhou Qi-Lin 
Published: June 2024

AbstractChiral amides are important structure in many natural products and pharmaceuticals, yet their efficient synthesis from simple amide feedstock remains challenge due to its weak Lewis basicity. Herein, we describe our study of the enantioselective synthesis of chiral amides by N-alkylation of primary amides taking advantage of an achiral rhodium and chiral squaramide co-catalyzed carbene N–H insertion reaction. This method features mild condition, rapid reaction rate (in all cases 1 min) and a wide substrate scope with high yield and excellent enantioselectivity. Further product transformations show the synthetic potential of this reaction. Mechanistic studies reveal that the non-covalent interactions between the catalyst and reaction intermediate play a critical role in enantiocontrol.
Multipolar condensates and multipolar Josephson effects
Authors: Xu Wenhui , Lv Chenwei , Zhou Qi 
Published: June 2024

AbstractWhen single-particle dynamics are suppressed in certain strongly correlated systems, dipoles arise as elementary carriers of quantum kinetics. These dipoles can further condense, providing physicists with a rich realm to study fracton phases of matter. Whereas recent theoretical discoveries have shown that an unconventional lattice model may host a dipole condensate as the ground state, we show that dipole condensates prevail in bosonic systems due to a self-proximity effect. Our findings allow experimentalists to manipulate the phase of a dipole condensate and deliver dipolar Josephson effects, where supercurrents of dipoles arise in the absence of particle flows. The self-proximity effects can also be utilized to produce a generic multipolar condensate. The kinetics of the n-th order multipoles unavoidably creates a condensate of the (n + 1)-th order multipoles, forming a hierarchy of multipolar condensates that will offer physicists a whole new class of macroscopic quantum phenomena.
Ultrafast electron transfer at the In2O3/Nb2O5 S-scheme interface for CO2 photoreduction
Authors: Deng Xianyu , Zhang Jianjun , Qi Kezhen , Liang Guijie , Xu Feiyan , Yu Jiaguo 
Published: June 2024

AbstractConstructing S-scheme heterojunctions proves proficient in achieving the spatial separation of potent photogenerated charge carriers for their participation in photoreactions. Nonetheless, the restricted contact areas between two phases within S-scheme heterostructures lead to inefficient interfacial charge transport, resulting in low photocatalytic efficiency from a kinetic perspective. Here, In2O3/Nb2O5 S-scheme heterojunctions are fabricated through a straightforward one-step electrospinning technique, enabling intimate contact between the two phases and thereby fostering ultrafast interfacial electron transfer (<10 ps), as analyzed via femtosecond transient absorption spectroscopy. As a result, powerful photo-electrons and holes accumulate in the Nb2O5 conduction band and In2O3 valence band, respectively, exhibiting extended long lifetimes and facilitating their involvement in subsequent photoreactions. Combined with the efficient chemisorption and activation of stable CO2 on the Nb2O5, the resulting In2O3/Nb2O5 hybrid nanofibers demonstrate improved photocatalytic performance for CO2 conversion.
Zebrafish Avatar-test forecasts clinical response to chemotherapy in patients with colorectal cancer
Authors: Costa Bruna , Estrada Marta F. , Gomes António , Fernandez Laura M. , Azevedo José M. , Póvoa Vanda , Fontes Márcia , Alves António , Galzerano António , Castillo-Martin Mireia , Herrando Ignacio , Brandão Shermann , Carneiro Carla , Nunes Vítor , Carvalho Carlos , Parvaiz Amjad , Marreiros Ana , Fior Rita 
Published: June 2024

AbstractCancer patients often undergo rounds of trial-and-error to find the most effective treatment because there is no test in the clinical practice for predicting therapy response. Here, we conduct a clinical study to validate the zebrafish patient-derived xenograft model (zAvatar) as a fast predictive platform for personalized treatment in colorectal cancer. zAvatars are generated with patient tumor cells, treated exactly with the same therapy as their corresponding patient and analyzed at single-cell resolution. By individually comparing the clinical responses of 55 patients with their zAvatar-test, we develop a decision tree model integrating tumor stage, zAvatar-apoptosis, and zAvatar-metastatic potential. This model accurately forecasts patient progression with 91% accuracy. Importantly, patients with a sensitive zAvatar-test exhibit longer progression-free survival compared to those with a resistant test. We propose the zAvatar-test as a rapid approach to guide clinical decisions, optimizing treatment options and improving the survival of cancer patients.
Difluorocarbene-induced [1,2]- and [2,3]-Stevens rearrangement of tertiary amines
Authors: Su Jianke , Guo Yu , Li Chengbo , Song Qiuling 
Published: June 2024

AbstractThe [1,2]- and [2,3]-Stevens rearrangements are one of the most fascinating chemical bond reorganization strategies in organic chemistry, and they have been demonstrated in a wide range of applications, representing a fundamental reaction tactic for the synthesis of nitrogen compounds in chemical community. However, their applicabilities are limited by the scarcity of efficient, general, and straightforward methods for generating ammonium ylides. Herein, we report a general difluorocarbene-induced tertiary amine-involved [1,2]- and [2,3]-Stevens rearrangements stemmed from in situ generated difluoromethyl ammonium ylides, which allows for the rearrangements of versatile tertiary amines bearing either allyl, benzyl, or propargyl groups, resulting in the corresponding products in one reaction under the same reaction conditions with a general way. Broad substrate scope, simple operation, mild reaction conditions and late-stage modification of natural products highlight the advantages of this strategy, meanwhile, this general rearrangement reaction is believed to bring opportunities for the transformations of nitrogen ylides and the assembly of valuable tertiary amines and amino acids. This will further enrich the reaction repertoire of difluorocarbene species, facilitate the development of reactions involving difluoromethyl ammonium salts, and provide an avenue for the development of this type of rearrangement reactions.
Targeting dependency on a paralog pair of CBP/p300 against de-repression of KREMEN2 in SMARCB1-deficient cancers
Authors: Sasaki Mariko , Kato Daiki , Murakami Karin , Yoshida Hiroshi , Takase Shohei , Otsubo Tsuguteru , Ogiwara Hideaki 
Published: June 2024

AbstractSMARCB1, a subunit of the SWI/SNF chromatin remodeling complex, is the causative gene of rhabdoid tumors and epithelioid sarcomas. Here, we identify a paralog pair of CBP and p300 as a synthetic lethal target in SMARCB1-deficient cancers by using a dual siRNA screening method based on the “simultaneous inhibition of a paralog pair” concept. Treatment with CBP/p300 dual inhibitors suppresses growth of cell lines and tumor xenografts derived from SMARCB1-deficient cells but not from SMARCB1-proficient cells. SMARCB1-containing SWI/SNF complexes localize with H3K27me3 and its methyltransferase EZH2 at the promotor region of the KREMEN2 locus, resulting in transcriptional downregulation of KREMEN2. By contrast, SMARCB1 deficiency leads to localization of H3K27ac, and recruitment of its acetyltransferases CBP and p300, at the KREMEN2 locus, resulting in transcriptional upregulation of KREMEN2, which cooperates with the SMARCA1 chromatin remodeling complex. Simultaneous inhibition of CBP/p300 leads to transcriptional downregulation of KREMEN2, followed by apoptosis induction via monomerization of KREMEN1 due to a failure to interact with KREMEN2, which suppresses anti-apoptotic signaling pathways. Taken together, our findings indicate that simultaneous inhibitors of CBP/p300 could be promising therapeutic agents for SMARCB1-deficient cancers.
General mechanisms of task engagement in the primate frontal cortex
Authors: Grohn Jan , Khalighinejad Nima , Jahn Caroline I , Bongioanni Alessandro , Schüffelgen Urs , Sallet Jerome , Rushworth Matthew F. S. , Kolling Nils 
Published: June 2024

AbstractStaying engaged is necessary to maintain goal-directed behaviors. Despite this, engagement exhibits continuous, intrinsic fluctuations. Even in experimental settings, animals, unlike most humans, repeatedly and spontaneously move between periods of complete task engagement and disengagement. We, therefore, looked at behavior in male macaques (macaca mulatta) in four tasks while recording fMRI signals. We identified consistent autocorrelation in task disengagement. This made it possible to build models capturing task-independent engagement. We identified task general patterns of neural activity linked to impending sudden task disengagement in mid-cingulate gyrus. By contrast, activity centered in perigenual anterior cingulate cortex (pgACC) was associated with maintenance of performance across tasks. Importantly, we carefully controlled for task-specific factors such as the reward history and other motivational effects, such as response vigor, in our analyses. Moreover, we showed pgACC activity had a causal link to task engagement: transcranial ultrasound stimulation of pgACC changed task engagement patterns.
Coexistence of state, choice, and sensory integration coding in barrel cortex LII/III
Authors: Gardères Pierre-Marie , Le Gal Sébastien , Rousseau Charly , Mamane Alexandre , Ganea Dan Alin , Haiss Florent 
Published: June 2024

AbstractDuring perceptually guided decisions, correlates of choice are found as upstream as in the primary sensory areas. However, how well these choice signals align with early sensory representations, a prerequisite for their interpretation as feedforward substrates of perception, remains an open question. We designed a two alternative forced choice task (2AFC) in which male mice compared stimulation frequencies applied to two adjacent vibrissae. The optogenetic silencing of individual columns in the primary somatosensory cortex (wS1) resulted in predicted shifts of psychometric functions, demonstrating that perception depends on focal, early sensory representations. Functional imaging of layer II/III single neurons revealed mixed coding of stimuli, choices and engagement in the task. Neurons with multi-whisker suppression display improved sensory discrimination and had their activity increased during engagement in the task, enhancing selectively representation of the signals relevant to solving the task. From trial to trial, representation of stimuli and choice varied substantially, but mostly orthogonally to each other, suggesting that perceptual variability does not originate from wS1 fluctuations but rather from downstream areas. Together, our results highlight the role of primary sensory areas in forming a reliable sensory substrate that could be used for flexible downstream decision processes.
Perception of motion salience shapes the emergence of collective motions
Authors: Xiao Yandong , Lei Xiaokang , Zheng Zhicheng , Xiang Yalun , Liu Yang-Yu , Peng Xingguang 
Published: June 2024

AbstractDespite the profound implications of self-organization in animal groups for collective behaviors, understanding the fundamental principles and applying them to swarm robotics remains incomplete. Here we propose a heuristic measure of perception of motion salience (MS) to quantify relative motion changes of neighbors from first-person view. Leveraging three large bird-flocking datasets, we explore how this perception of MS relates to the structure of leader-follower (LF) relations, and further perform an individual-level correlation analysis between past perception of MS and future change rate of velocity consensus. We observe prevalence of the positive correlations in real flocks, which demonstrates that individuals will accelerate the convergence of velocity with neighbors who have higher MS. This empirical finding motivates us to introduce the concept of adaptive MS-based (AMS) interaction in swarm model. Finally, we implement AMS in a swarm of ~102 miniature robots. Swarm experiments show the significant advantage of AMS in enhancing self-organization of the swarm for smooth evacuations from confined environments.
Supramolecular assembly activated single-molecule phosphorescence resonance energy transfer for near-infrared targeted cell imaging
Authors: Zhou Xiaolu , Bai Xue , Shang Fangjian , Zhang Heng-Yi , Wang Li-Hua , Xu Xiufang , Liu Yu 
Published: June 2024

AbstractPure organic phosphorescence resonance energy transfer is a research hotspot. Herein, a single-molecule phosphorescence resonance energy transfer system with a large Stokes shift of 367 nm and near-infrared emission is constructed by guest molecule alkyl-bridged methoxy-tetraphenylethylene-phenylpyridines derivative, cucurbit[n]uril (n = 7, 8) and β-cyclodextrin modified hyaluronic acid. The high binding affinity of cucurbituril to guest molecules in various stoichiometric ratios not only regulates the topological morphology of supramolecular assembly but also induces different phosphorescence emissions. Varying from the spherical nanoparticles and nanorods for binary assemblies, three-dimensional nanoplate is obtained by the ternary co-assembly of guest with cucurbit[7]uril/cucurbit[8]uril, accompanying enhanced phosphorescence at 540 nm. Uncommonly, the secondary assembly of β-cyclodextrin modified hyaluronic acid and ternary assembly activates a single intramolecular phosphorescence resonance energy transfer process derived from phenyl pyridines unit to methoxy-tetraphenylethylene function group, enabling a near-infrared delayed fluorescence at 700 nm, which ultimately applied to mitochondrial targeted imaging for cancer cells.