bluuebunny/crossref_metadata_2025_split huggingface dataset:
Morbidity and mortality after liver resection for benign and malignant hepatobiliary lesions
Authors: Erdogan Deha , Busch Olivier R. C. , Gouma Dirk J. , Van Gulik Thomas M. 
Published: March 2010

AbstractAim: Although most partial liver resections are performed for malignant lesions, an increasing contingent of benign lesions is also considered for surgery. The aim was to assess post‐operative morbidity and mortality after liver resection for benign hepatobiliary lesions in comparison with outcome after resection of malignant lesions.Methods: A total of 286 liver resections were undertaken between January 1992 and December 2004. After exclusion of resection for bile duct tumours or hepatocellular carcinoma, 205 partial liver resections were retrospectively analysed.Results: Patients with benign lesions comprised 34% of the group (n=70). Benign lesions mainly consisted of focal nodular hyperplasia (n=12; 17%) and liver haemangiomas (11; 15.7%). The malignant lesions consisted of colorectal tumour metastases (n=121; 89%). Patients with benign lesions predominantly underwent minor liver resections (66 vs. 47%; P=0.013). The overall post‐operative morbidity occurred in 31% (64/205). Major morbidity occurred in 16% (22/135) in the malignant group compared with 9% (6/70) in the benign group (P=0.099). No differences were seen in major post‐operative morbidity in the earlier period compared with the later period (14 vs. 14.3%, P=0.950). In multivariate analysis, only presence of comorbidity (P=0.017), prolonged surgical procedure (P=0.021) and surgical irradicality (P=0.039) maintained significance as independent risk factors for major morbidity.Conclusion: Limited liver resections for the treatment of a wide range of benign hepatobiliary lesions are associated with low morbidity and no mortality. However, the indications must be assessed with care. The presence of comorbidity, prolonged surgical time and incomplete resections were associated with major morbidity.
Non‐alcoholic fatty liver disease and its association with obesity, insulin resistance and increased serum levels of C‐reactive protein in Hispanics
Authors: Riquelme Arnoldo , Arrese Marco , Soza Alejandro , Morales Arturo , Baudrand René , Pérez‐Ayuso Rosa María , González Robinson , Alvarez Manuel , Hernández Verónica , García‐Zattera María José , Otarola Francisco , Medina Brenda , Rigotti Attilio , Miquel Juan Francisco , Marshall Guillermo , Nervi Flavio 
Published: March 2010

AbstractBackground: Non‐alcoholic fatty liver disease (NAFLD) is a metabolic disorder of the liver, which may progress to fibrosis or cirrhosis. Recent studies have shown a significant impact of ethnicity on susceptibility to steatosis‐related liver disease.Aims: To estimate the prevalence of NAFLD among Chilean Hispanics as well as the clinical and biochemical variables associated with the disease.Methods: Population‐based study among Chilean Hispanics. The diagnosis of NAFLD was made on the basis of ultrasound evidence of fatty liver and absence of significant alcohol consumption and hepatitis C virus infection.Results: A total of 832 Hispanic subjects were included. Ultrasound findings revealed diffuse fatty liver in 23% of the subjects. Variables associated with fatty liver in multivariate analysis were body mass index >26.9 [odds ratio (OR) 6.2; 95% confidence interval (CI) 3.3–11.5], abnormal aspartate aminotransferase levels (OR 14; 95% CI 8.2–23.7), presence of insulin resistance as measured by homoeostasis model assessment‐insulin resistance (OR 3; 95% CI 1.8–4.8) and serum levels of high‐sensitivity C‐reactive protein (hs‐CRP) greater than 0.86 mg/L (OR 2.9; 95% CI 1.6–5.2). Among subjects with NAFLD, levels of hs‐CRP were similar regardless of the alanine aminotransferase (ALT) level.Conclusions: Chilean Hispanics exhibit a high prevalence of NAFLD. Obesity, insulin resistance, abnormal aminotransferase levels and elevated hs‐CRP were independently associated with the presence of NAFLD. ALT elevation underestimates the presence of ultrasonographical fatty liver, whereas hs‐CRP is a sensitive independent marker of NAFLD, which may be useful for detecting fatty liver in the general population.
Homocysteine levels and sustained virological response to pegylated‐interferon α2b plus ribavirin therapy for chronic hepatitis C: a prospective study
Authors: Borgia Guglielmo , Gentile Ivan , Fortunato Giuliana , Borrelli Francesco , Borelli Salvatore , De Caterina Maurizio , Di Taranto Maria Donata , Simone Maria , Borgia Federico , Viola Chiara , Reynaud Laura , Cerini Raimondo , Sacchetti Lucia 
Published: March 2010

AbstractBackground: Chronic hepatitis C affects about 3% of the world's population. Pegylated interferon (IFN) α plus ribavirin is the gold standard treatment. Methylenetetrahydrofolate reductase(MTHFR) is a key enzyme in the metabolism of homocysteine. MTHFR gene polymorphisms and high levels of homocysteine are associated with a high degree of steatosis and fibrosis, conditions associated with a low sustained virological response (SVR) rate.Aims: To evaluate whether MTHFR polymorphisms and homocysteine levels are predictors of the outcome of treatment in 102 prospectively enrolled patients with chronic hepatitis C naive to treatment.Methods: Patients were treated with pegylated interferon α‐2b plus ribavirin. All patients underwent blood tests, assessment of homocysteine, vitamin B12, folate, hepatitis C virus (HCV)‐RNA levels, screening for MTHFR gene polymorphisms and liver ultrasound examination.Results: Homocysteine levels were deranged (>16 μmol/L) in 10.5% of MTHFR wild‐type patients vs 40.3% of non‐wild‐type patients (P=0.015). Homocysteine levels were 14.4 μmol/L in SVR patients and 15.5 μmol/L in non‐SVR patients (P=0.049). The SVR rate was 40.0% in MTHFR wild‐type patients, 52.0% in heterozygote mutants and 39.3% in homozygote mutants (P=0.467). At logistic regression analysis, genotypes 2 and 3 (odds ratio: 12.328, 95% confidence interval: 3.390–44.837, P=0.0001), homocysteine <16 μmol/L (odds ratio: 3.397, 95% confidence interval: 1.033–11.177, P=0.044) and aspartate aminotransferase (AST) levels <48 U/L (odds ratio: 3.262, 95% confidence interval: 1.125–9.458, P=0.029) were independent predictors of SVR.Conclusions: In patients with chronic hepatitis C, homocysteine levels are associated with the outcome of pegylated‐IFNα plus ribavirin treatment, while polymorphisms of MTHFR are not.
Prognostic factors and evaluation of a clinical score for predicting survival after resection of colorectal liver metastases
Authors: Konopke Ralf , Kersting Stephan , Distler Marius , Dietrich Jeannine , Gastmeier Jörg , Heller Axel , Kulisch Eberhard , Saeger Hans‐Detlev 
Published: March 2010

AbstractBackground: Patient outcome after resection of colorectal liver metastases can be predicted by various prognostic factors.Aims: Development of a model for risk stratification based on analysis of prognostic factors.Methods: Data of 201 patients were collected prospectively and included in a single‐centre trial. A total of 20 factors were analysed as to their influence on recurrence‐free and overall survival. Independent prognostic factors were entered into a model of a clinical risk score.Results: Median recurrence‐free survival reached 24 months for all patients; median overall survival was 50 months. Only a synchronous manifestation of primary colorectal carcinoma and liver metastases, the presence of four or more metastases and a carcino‐embryonic antigen level of 200 ng/ml or more significantly influenced recurrence‐free and overall survival in the multivariate analysis. The derived risk stratification grouped the patients according to the following criteria: low risk, zero prognostic factors (n=112); intermediate risk, one factor (n=74); high risk, two or more factors (n=15). The median recurrence‐free survival for low, intermediate and high risk were 30.0, 23.0 and 11.0 months, respectively; the median overall survival was 94.0, 40.0 and 33.0 months. Compared with the low‐risk group, patients with intermediate risk demonstrated an increased hazard ratio (HR) of 1.57‐fold for recurrence (P=0.018) and 1.91‐fold for mortality (P=0.007). For the high‐risk group, the HR rose significantly to 3.26 for recurrence (P<0.0005) and to 3.10 for mortality (P=0.001).Conclusions: The presented clinical score may allow for patients with colorectal liver metastases to be stratified appropriately and for optimization of their subsequent therapeutic management.
A multicenter retrospective cohort study of practice patterns and clinical outcome on radiotherapy for hepatocellular carcinoma in Korea
Authors: Seong Jinsil , Lee Ik Jae , Shim Su Jung , Lim Do Hoon , Kim Tae Hyun , Kim Jong Hoon , Jang Hong Seok , Kim Mi Sook , Chie Eui Kyu , Kim Jin Hee , Nam Taek‐Keun , Lee Hyung Sik , Han Chul Joo 
Published: March 2010

AbstractAim: To determine the national practice processes of care and outcomes of radiotherapy for hepatocellular carcinoma (HCC) in Korea.Patients and Methods: A national survey of 53 institutions nationwide was conducted by requesting data on their experience of radiotherapy for HCC. Among them, 10 institutions were selected for performing more detailed analysis, based on the radiotherapy experience of at least five HCC patients between 2004 and 2005.Results: This study covered the treatment of 398 HCC patients for 2 years. Most patients (78%) were in stage III or IV. Radiotherapy was chosen after the failure of other treatments, most frequently transarterial chemoembolization. Radiotherapy was performed predominantly using the three‐dimensional conformal technique (3D‐CRT, 81.9%) mostly with a total dose of ≥45 Gy. In 9.3% of the patients, radiotherapy was performed using radiosurgery. In a biologically effective dose (BED) with 10 Gy of α/β, 4.2–124.3 Gy10 was delivered. The median survival time was 12 months, and the 2‐year overall survival rate was 27.9%. A tumour size <5 cm, a negative lymph node and BED >53.1 Gy10 were shown by multivariate analysis to be significant factors for a better prognosis. In a subset analysis for the 326 patients treated with 3D‐CRT, better liver function with Child–Pugh class A was shown to be an additional factor for a better prognosis.Conclusions: Radiotherapy has been used to treat advanced HCC in various modes, but mostly as a salvage treatment. Although this study was retrospective, it indicates that radiotherapy is a quite effective modality for HCC patients.
Industrial Recycling Networks as Starting Points for Broader Sustainability‐Oriented Cooperation?
Authors: Posch Alfred 
Published: March 2010

SummaryClosing loops by intercompany recycling of by‐products is a core theme of industrial ecology (IE). This article considers whether industrial recycling networks or industrial symbiosis projects can be used as a starting point for much broader intercompany cooperation for sustainable development. Evidence presented is based on the results of an empirical investigation of the recycling network Styria in Austria, the recycling network Oldenburger Münsterland in Germany, and the manufacturing sector in Austria.Statistical analysis shows that the percentage of by‐products that are passed on to other companies for recycling purposes is not higher in member companies of the recycling networks than in the other companies of the manufacturing sector in Austria. In terms of cooperation, the relationships with the respective recycling partners are found to be very similar to regular customer relations. Furthermore, the companies of the recycling networks remain unaware of the network to which they belong. Instead, one of the main findings of this study is that intercompany recycling activities are regarded by the company representatives as bilateral market transactions, not as collaborative network activities.This has potentially significant implications for the use of industrial symbiosis networks as starting points for sustainability networks with broader cooperation toward sustainability. The findings raise interesting questions as to whether such broader cooperation might result from a conscious planning process or might emerge largely spontaneously as part of normal market coordination. In any case, intercompany recycling is clearly considered to be a very important field of collaborative action for sustainability in industry.
Maximum Daily 6 Minutes of Activity: An Index of Functional Capacity Derived from Actigraphy and Its Application to Older Adults with Heart Failure
Authors: Howell Jason , Strong B. Michelle , Weisenberg Jenny , Kakade Anagha , Gao Qian , Cuddihy Paul , Delisle Susan , Kachnowski Stan , Maurer Mathew S. 
Published: March 2010

OBJECTIVES: To compare the correlation between the maximum 6 minutes of daily activity (M6min) and standard measures of functional capacity in older adults with heart failure (HF) with that in younger subjects and its prognostic utility.DESIGN: Prospective, cohort study.SETTING: Tertiary care, academic HF center.PARTICIPANTS: Sixty, ambulatory, adults, New York Heart Association (NYHA) Class I to III, stratified into young (50.9 ± 9.4) and older cohorts (76.8 ± 8.0).MEASUREMENTS:Correlation between M6min and measures of functional capacity (6‐minute walk test; 6MWT) and peak oxygen consumption (VO2) according to cardiopulmonary exercise testing in a subset of subjects. Survival analysis was employed to evaluate the association between M6min and adverse events.RESULTS: Adherence to actigraphy was high (90%) and did not differ according to age. The correlation between M6min and 6MWT was higher in subjects aged 65 and older than in those younger than 65 (correlation coefficient (r=0.702, P<.001 vs r=0.490, P=.002). M6min was also significantly associated with peak VO2 (r=0.612, P=.006). During the study, 26 events occurred (2 deaths, 10 hospitalizations, 8 emergency department visits, and 6 intercurrent illnesses). The M6min was significantly associated with subsequent events (hazard ratio=2.728, 95% confidence interval=1.10–6.77, P=.03), independent of age, sex, ejection fraction, NYHA class, brain natriuretic peptide, and 6MWT.CONCLUSION: The high adherence to actigraphy and association with standard measures of functional capacity and independent association with subsequent morbid events suggest that it may be useful for monitoring older adults with HF.
Depressive Symptoms and Cognitive Decline in Community‐Dwelling Older Adults
Authors: Köhler Sebastian , van Boxtel Martin P.J. , van Os Jim , Thomas Alan J. , O'Brien John T. , Jolles Jelle , Verhey Frans R.J. , Allardyce Judith 
Published: March 2010

OBJECTIVES: To examine the temporal association between depressive symptoms and cognitive functioning and estimate the effect measure modification of the apolipoprotein E (APOE) ɛ4 allele on this relationship.DESIGN: Prospective cohort study.SETTING: General community.PARTICIPANTS: Population‐based sample of 598 cognitively intact older adults aged 60 and older, with re‐assessments after 3 (N=479) and 6 years (N=412).MEASUREMENTS: Depressive symptoms (Symptom Checklist) and neurocognitive functioning (memory, Visual Verbal Learning Test; attention, Stroop Color–Word Test; processing speed, Letter Digit Substitution Test; general cognition, Mini‐Mental State Examination). Longitudinal associations were assessed using linear mixed models. The risk for cognitive impairment, no dementia (CIND) was examined using logistic regression.RESULTS: Adjusting for age, sex, education, and baseline cognition, the rate of change in memory z‐scores was 0.00, −0.11, −0.20, and −0.37 for those in the lowest (reference group), second, third, and highest depressive symptom quartiles at baseline, respectively (P<.001 for highest vs lowest quartile). The odds ratios for developing CIND with amnestic features were 1.00, 0.87, 0.69, and 2.98 for the four severity groups (P=.05 for highest vs lowest quartile). Associations were strongest for those with persistent depressive symptoms, defined as high depressive symptoms at baseline and at least one follow‐up visit. Results were similar for processing speed and global cognitive function but were not as strong for attention. No APOE interaction was observed.CONCLUSION: Depression and APOE act independently to increase the risk for cognitive decline and may provide targets for prevention and early treatment.
Temporary Test Occlusion of Distal Middle Cerebral Artery Using GDC Coil
Authors: Douds G. Logan , Kalapos Paul , Cockroft Kevin M. 
Published: March 2010

ABSTRACT The treatment of small distal intracranial aneurysms often requires parent vessel occlusion. However, this may be particularly challenging in patients in which the parent vessel serves eloquent brain. Superselective amytal testing is often conducted in these cases, but may prove unreliable or inconclusive. In order to more specifically assess the functional significance of the parent vessel in this patient with a distal left middle cerebral artery pseudoaneurysm who had failed superselective amytal testing, we used a Guglielmi Detachable coil to perform a temporary test occlusion. Testing was performed with the patient awake and examinable, and after no neurological changes were noted, the vessel was permanently occluded, successfully treating the aneurysm. To our knowledge, this is the first report to describe this unique method for assessing a parent vessel that previously had been thought to supply eloquent brain during amytal testing.
Structural Correlates of Functional Language Dominance: A Voxel‐Based Morphometry Study
Authors: Jansen Andreas , Liuzzi Gianpiero , Deppe Michael , Kanowski Martin , Ölschläger Christian , Albers Johannes M. , Schlaug Gottfried , Knecht Stefan 
Published: March 2010

ABSTRACTBACKGROUND AND PURPOSE The goal of this study was to explore the structural correlates of functional language dominance by directly comparing the brain morphology of healthy subjects with left‐ and right‐hemisphere language dominance. METHODS Twenty participants were selected based on their language dominance from a cohort of subjects with known language lateralization. Structural differences between both groups were assessed by voxel‐based morphometry, a technique that automatically identifies differences in the local gray matter volume between groups using high‐resolution T1‐weighted magnetic resonance images. RESULTS The main findings can be summarized as follows: (1) Subjects with right‐hemisphere language dominance had significantly larger gray matter volume in the right hippocampus than subjects with left‐hemisphere language dominance. (2) Leftward structural asymmetries in the posterior superior temporal cortex, including the planum temporale (PT), were observed in both groups. CONCLUSIONS Our study does not support the still prevalent view that asymmetries of the PT are related in a direct way to functional language lateralization. The structural differences found in the hippocampus underline the importance of the medial temporal lobe in the neural language network. They are discussed in the context of recent findings attributing a critical role of the hippocampus in the development of language lateralization.
Quantitative and Qualitative Measures of Hippocampal Atrophy Are Not Correlated in Healthy Older Men
Authors: Ferguson Karen J. , Wardlaw Joanna M. , MacLullich Alasdair M. J. 
Published: March 2010

ABSTRACTBACKGROUND AND PURPOSE In neuroimaging studies of dementia and mild cognitive impairment, hippocampal atrophy (HA) is commonly assessed by qualitative ratings of hippocampal appearance, or by measuring hippocampal volumes. These estimates of HA are considered to be equivalent. However, few studies have examined their relationship, especially in healthy older individuals. We therefore examined the relationship between hippocampal qualitative atrophy scores and quantitative volumetric measurements in healthy older men. METHODS Ninety‐seven healthy community‐dwelling 65‐70‐year‐old men underwent magnetic resonance imaging scanning. Hippocampal volumes were measured and adjusted for intracranial size. A validated 4‐point visual rating scale was used to assess hippocampal atrophy. RESULTS There was a wide range of unadjusted hippocampal volumes among subjects (right: 2,582 to 5,196 mm3[mean 3,626 mm3; SD 465.5 mm3] and left: 2,111 to 4,580 mm3[mean 3,501 mm3; SD 439.5 mm3]), which was maintained following adjustment for intracranial size. However, only 9% of subjects were rated as having moderate or severe HA. Qualitative and quantitative measures were not significantly correlated (left hippocampus: rho = .07, P= .52; right hippocampus: rho = .10, P= .34). CONCLUSIONS This study shows that qualitative and quantitative indices of hippocampal atrophy in healthy older men are not equivalent. Small hippocampal volumes do not necessarily equate to hippocampal atrophy.
Meta‐regression analysis of the initial bone height for predicting implant survival rates of two sinus elevation procedures
Authors: Chao Yueh‐Ling , Chen Hsiu‐His , Mei Chih‐Chun , Tu Yu‐Kang , Lu Hsein‐Kun 
Published: March 2010

Chao Y‐L, Chen H‐H, Mei C‐C, Tu Y‐K, Lu H‐K. Meta‐regression analysis of the initial bone height for predicting implant survival rates of two sinus elevation procedures. J Clin Periodontol 2010; 37: 456–465. doi: 10.1111/j.1600‐051X.2010.01555.x.AbstractAim: To undertake a systematic review for the association between the initial alveolar bone height and the success of dental implants with sinus elevation procedures.Materials and Methods: An online search was performed using the following electronic databases: PubMed, Medline, Science Direct, and Blackwell synergy. Two investigators independently assessed publications for inclusion and extracted data. Meta‐regression analyses were used to test the associations between the initial alveolar bone height and implant survival with lateral window or osteotome sinus elevation procedures.Results: Of 635 studies, 21 were included for analysis. A quadratic curve‐fitting meta‐regression showed an increasing trend of implant survival rate with greater initial bone height for the lateral window technique (p<0.0001, adjusted R2=0.97). The result of the meta‐regression for hazard rates showed a decreasing trend (p=0.0041, adjusted R2=0.89). No association was found for the osteotome technique.Conclusions: For the lateral window technique, meta‐regression analysis suggested a positive association between the initial alveolar bone height and implant survival rates. No relationship was found between the initial alveolar bone height and implant survival rate for the osteotome technique due to a lack of data below 4 mm of initial bone height.