bluuebunny/crossref_metadata_2025_split huggingface dataset:
Individual and contextual‐level predictors of progression in the bystander intervention model
Authors: Nickerson Amanda B. , Jenkins Lyndsay N. , Yang Yanyun , Harrison Dylan S. 
Published: June 2024

AbstractThe situational model of bystander behavior is a validated 5‐step process for understanding intervention in bullying and sexual harassment, yet the individual‐level and contextual‐level factors that facilitate the progression from one step to the next are not well understood. The purpose of the current study was to examine whether individual characteristics (social‐emotional skills, affective empathy, cognitive empathy, and personal attitudes toward bullying and sexual harassment) and contextual‐level factors (school climate and perceived peer attitudes toward bullying and sexual harassment) explained the association between subsequent steps of the bystander intervention model. A sample of 788 high school students completed several validated measures of these constructs. Structural equation modeling analysis revealed that each step significantly and positively predicted the next step, and the addition of a direct path from accepting responsibility to helping improved model fit. The mediational model indicated that individual‐level characteristics had significant direct effects on interpreting bullying and sexual harassment as problems, accepting responsibility, and helping, and indirect effects from noticing the bullying and sexual harassment to all subsequent steps except knowing. In contrast, contextual‐level effects contributed to accepting responsibility in an inverse direction.
Exposure to aggression in three contexts of emergency response: A longitudinal examination of the relationship with psychological characteristics of the emergency responder
Authors: van Reemst Lisa , Jongerling Joran 
Published: June 2024

AbstractSome emergency responders are more often exposed to workplace aggression than others. Victimological theories and previous studies suggest that characteristics of the target may predict exposure to workplace aggression. This paper examines the relationship between negative affect, hostile attribution, dominance, empathy, self‐evaluations, and exposure to workplace aggression among emergency responders. Emergency medical workers, firefighters and police officers in the Netherlands filled in a survey during three measurement occasions (6 months apart). Results from the three occupational groups were presented separately. Results suggest that some psychological characteristics are related to exposure to workplace aggression, but that the contribution of these characteristics in the explanation of exposure to workplace aggression is limited. In addition, although differences between occupational groups could not be statistically tested due to differences in the factor structure of exposure to workplace aggression between the three groups of emergency response, differences seem to occur in models between emergency response contexts. Implications and suggestions for future research are discussed.
Tracing Immunological Interaction in Trimethylamine N‐Oxide Hydrogel‐Derived Zwitterionic Microenvironment During Promoted Diabetic Wound Regeneration
Authors: Li Zheng , Li Longwei , Yue Muxin , Peng Qingyu , Pu Xiong , Zhou Yongsheng 
Published: June 2024

AbstractThe diabetic wound healing is challenging due to the sabotaged delicate balance of immune regulation via an undetermined pathophysiological mechanism, so it is crucial to decipher multicellular signatures underlying diabetic wound healing and seek therapeutic strategies. Here, this work develops a strategy using novel trimethylamine N‐oxide (TMAO)‐derived zwitterionic hydrogel to promote diabetic wound healing, and explore the multi‐cellular ecosystem around zwitterionic hydrogel, mapping out an overview of different cells in the zwitterionic microenvironment by single‐cell RNA sequencing. The diverse cellular heterogeneity is revealed, highlighting the critical role of macrophage and neutrophils in managing diabetic wound healing. It is found that polyzwitterionic hydrogel can upregulate Ccl3+ macrophages and downregulate S100a9+ neutrophils and facilitate their interactions compared with polyanionic and polycationic hydrogels, validating the underlying effect of zwitterionic microenvironment on the activation of adaptive immune system. Moreover, zwitterionic hydrogel inhibits the formation of neutrophil extracellular traps (NETs) and promotes angiogenesis, thus improving diabetic wound healing. These findings expand the horizons of the sophisticated orchestration of immune systems in zwitterion‐directed diabetic wound repair and uncover new strategies of novel immunoregulatory biomaterials.
Quantifying Asymmetric Zinc Deposition: A Guide Factor for Designing Durable Zinc Anodes
Authors: Wang Shixun , Huang Zhaodong , Zhu Jiaxiong , Wang Yiqiao , Li Dedi , Wei Zhiquan , Hong Hu , Zhang Dechao , Xiong Qi , Li Shimei , Chen Ze , Li Nan , Zhi Chunyi 
Published: June 2024

AbstractZinc metal is recognized as the most promising anode for aqueous energy storage but suffers from severe dendrite growth and poor reversibility. However, the coulombic efficiency lacks specificity for zinc dendrite growth, particularly in Zn||Zn symmetric cells. Herein, a novel indicator (fD) based on the characteristic crystallization peaks is proposed to evaluate the growth and distribution of zinc dendrites. As a proof of concept, triethylenetetramine (TETA) is adopted as an electrolyte additive to manipulate the zinc flux for uniform deposition, with a corroborating low fD value. A highly durable zinc symmetric cell is achieved, lasting over 2500 h at 10 mA cm−2 and 400 h at a large discharge of depth (10 mA cm−2, 10 mAh cm−2). Supported by the low fD value, the Zn||TETA‐ZnSO4||MnO2 batteries overcome the sudden short circuit and fast capacity fading. The study provides a feasible method to evaluate zinc dendrites and sheds light on the design of highly reversible zinc anodes.
Gut Dysbiosis Drives Inflammatory Bowel Disease Through the CCL4L2‐VSIR Axis in Glycogen Storage Disease
Authors: Lan Jiaoli , Zhang Yuxin , Jin Cuiyuan , Chen Huan , Su Zexiong , Wu Jiaxing , Ma Ni , Zhang Xiaoyan , Lu Yiyun , Chen Yongxin , Zeng Xiaolu , Zhang Huiqiong , Zheng Guilang , Sun Yueyu , Wang Chun , Hu Yan , Wang Yifei , Liu Yumei , Zeng Zhaoyang , Shi Liyun , He Jun , Cao Aihua , Wang Yichao , Pan Xu , Jin Gulei , Wang Ying , Jiang Xun , Shen Huiqing , Tang Qing , Xie Xiaoli , Xiao Yuan , Zhong Xuemei , Zhang Xuchao , Zeng Liang , Ye Liping , Xie Jing , Geng Lanlan , Li Zhiling , Wu Xiaohui , Wang Ying , Mao Ren , Zhang Shaojun , Huang Siyuan , Liu Suling , Zeng Hanshi , Xu Wanfu , Gong Sitang , Guo Yuxiong , Yang Min 
Published: June 2024

AbstractPatients with glycogen storage disease type Ib (GSD‐Ib) frequently have inflammatory bowel disease (IBD). however, the underlying etiology remains unclear. Herein, this study finds that digestive symptoms are commonly observed in patients with GSD‐Ib, presenting as single or multiple scattered deep round ulcers, inflammatory pseudo‐polyps, obstructions, and strictures, which differ substantially from those in typical IBD. Distinct microbiota profiling and single‐cell clustering of colonic mucosae in patients with GSD are conducted. Heterogeneous oral pathogenic enteric outgrowth induced by GSD is a potent inducer of gut microbiota immaturity and colonic macrophage accumulation. Specifically, a unique population of macrophages with high CCL4L2 expression is identified in response to pathogenic bacteria in the intestine. Hyper‐activation of the CCL4L2‐VSIR axis leads to increased expression of AGR2 and ZG16 in epithelial cells, which mediates the unique progression of IBD in GSD‐Ib. Collectively, the microbiota‐driven pathomechanism of IBD is demonstrated in GSD‐Ib and revealed the active role of the CCL4L2‐VSIR axis in the interaction between the microbiota and colonic mucosal immunity. Thus, targeting gut dysbiosis and/or the CCL4L2‐VISR axis may represent a potential therapy for GSD‐associated IBD.
GbPP2C80 Interacts with GbWAKL14 to Negatively Co‐Regulate Resistance to Fusarium and Verticillium wilt via MPK3 and ROS Signaling in Sea Island Cotton
Authors: Zhao Nan , Guo Anhui , Wang Weiran , Li Bin , Wang Meng , Zhou Zixin , Jiang Kaiyun , Aierxi Alifu , Wang Baoliang , Adjibolosoo Daniel , Xia Zhanghao , Li Huijing , Cui Yanan , Kong Jie , Hua Jinping 
Published: June 2024

AbstractFusarium wilt (FW) is widespread in global cotton production, but the mechanism underlying FW resistance in superior‐fiber‐quality Sea Island cotton is unclear. This study reveals that FW resistance has been the target of genetic improvement of Sea Island cotton in China since the 2010s. The key nonsynonymous single nucleotide polymorphism (SNP, T/C) of gene Gbar_D03G001670 encoding protein phosphatase 2C 80 (PP2C80) results in an amino acid shift (L/S), which is significantly associated with FW resistance of Sea Island cotton. Silencing GbPP2C80 increases FW resistance in Sea Island cotton, whereas overexpressing GbPP2C80 reduces FW resistance in Arabidopsis. GbPP2C80 and GbWAKL14 exist synergistically in Sea Island cotton accessions with haplotype forms “susceptible–susceptible” (TA) and “resistant–resistant” (CC), and interact with each other. CRISPR/Cas9‐mediated knockout of GbWAKL14 enhances FW and Verticillium wilt (VW) resistance in upland cotton and overexpression of GbWAKL14 and GbPP2C80 weakens FW and VW resistance in Arabidopsis. GbPP2C80 and GbWAKL14 respond to FW and VW by modulating reactive oxygen species (ROS) content via affecting MPK3 expression. In summary, two tandem genes on chromosome D03, GbPP2C80, and GbWAKL14, functions as cooperative negative regulators in cotton wilt disease defense, providing novel genetic resources and molecular markers for the development of resistant cotton cultivars.
Thermodynamics‐Guided High‐Throughput Discovery of Eutectic High‐Entropy Alloys for Rapid Solidification
Authors: Han Liuliu , Sun Zhongji , Xia Wenzhen , Tsai Shao‐Pu , Zhang Xukai , Rao Jing , Wang Pei , Ngo Andrew Chun Yong , Li Zhiming , Liu Yong , Raabe Dierk 
Published: June 2024

AbstractExcellent castability, significantly refined microstructure, and good mechanical properties make eutectic high‐entropy alloys (EHEAs) a natural fit for rapid solidification processes, e.g., additive manufacturing. Previous investigations have focused on developing EHEAs through trial and error and mixing known binary eutectic materials. However, eutectic compositions obtained from near‐equilibrium conditions do not guarantee a fully eutectic microstructure under rapid solidifications. In this work, a thermodynamically guided high‐throughput framework is proposed to design EHEAs for rapid solidification. Empirical formulas derived from past experimental observations and thermodynamic computations are applied and considered phase growth kinetics under rapid solidification (skewed phase diagram). The designed alloy candidate, Co25.6Fe17.9Ni22.4Cr19.1Ta8.9Al6.1 (wt.%), contains nanostructured eutectic lamellar and shows a high Vickers hardness of 675 Hv. In addition to this specific composition, the alloy design toolbox enables the development of new EHEAs for rapid solidification without the limitation of previous knowledge.
Nanobody‐Engineered Biohybrid Bacteria Targeting Gastrointestinal Cancers Induce Robust STING‐Mediated Anti‐Tumor Immunity
Authors: Xu Xiaolong , Ding Youbin , Dong Yafang , Yuan Haitao , Xia Peng , Qu Chengming , Ma Jingbo , Wang Huifang , Zhang Xiaodong , Zhao Liang , Li Zhijie , Liang Zhen , Wang Jigang 
Published: June 2024

AbstractBacteria can be utilized for cancer therapy owing to their preferential colonization at tumor sites. However, unmodified non‐pathogenic bacteria carry potential risks due to their non‐specific targeting effects, and their anti‐tumor activity is limited when used as monotherapy. In this study, a biohybrid‐engineered bacterial system comprising non‐pathogenic MG1655 bacteria modified with CDH17 nanobodies on their surface and conjugated with photosensitizer croconium (CR) molecules is developed. The resultant biohybrid bacteria can efficiently home to CDH17‐positive tumors, including gastric, pancreatic, and colorectal cancers, and significantly suppress tumor growth upon irradiation. More importantly, biohybrid bacteria‐mediated photothermal therapy (PTT) induced abundant macrophage infiltration in a syngeneic murine colorectal model. Further, that the STING pathway is activated in tumor macrophages by the released bacterial nucleic acid after PTT is revealed, leading to the production of type I interferons. The addition of CD47 nanobody but not PD‐1 antibody to the PTT regimen can eradicate the tumors and extend survival. This results indicate that bacteria endowed with tumor‐specific selectivity and coupled with photothermal payloads can serve as an innovative strategy for low‐immunogenicity cancers. This strategy can potentially reprogram the tumor microenvironment by inducing macrophage infiltration and enhancing the efficacy of immunotherapy targeting macrophages.
Stable and Lead‐Safe Polyphenol‐Encapsulated Perovskite Solar Cells
Authors: Dipta Shahriyar Safat , Christofferson Andrew J. , Kumar Priyank V. , Kundi Varun , Hanif Muhammad , Tang Jianbo , Flores Nieves , Kalantar‐Zadeh Kourosh , Uddin Ashraf , Rahim Md. Arifur 
Published: June 2024

AbstractLead (Pb) halide perovskite solar cells (PSCs) exhibit impressive power conversion efficiencies close to those of their silicon counterparts. However, they suffer from moisture instability and Pb safety concerns. Previous studies have endeavoured to address these issues independently, yielding minimal advancements. Here, a general nanoencapsulation platform using natural polyphenols is reported for Pb‐halide PSCs that simultaneously addresses both challenges. The polyphenol‐based encapsulant is solution‐processable, inexpensive (≈1.6 USD m−2), and requires only 5 min for the entire process, highlighting its potential scalability. The encapsulated devices with a power conversion efficiency of 20.7% retained up to 80% of their peak performance for 2000 h and up to 70% for 7000 h. Under simulated rainfall conditions, the encapsulant rich in catechol groups captures the Pb ions released from the degraded perovskites via coordination, keeping the Pb levels within the safe drinking water threshold of 15 ppb.
Development of a prediction model for cognitive impairment of sarcopenia using multimodal neuroimaging in non‐demented older adults
Authors: Kim Sunghwan , Wang Sheng‐Min , Kang Dong Woo , Um Yoo Hyun , Yoon Han Min , Lee Soyoung , Choe Yeong Sim , Kim Regina EY , Kim Donghyeon , Lee Chang Uk , Lim Hyun Kook 
Published: June 2024

AbstractINTRODUCTIONDespite prior research on the association between sarcopenia and cognitive impairment in the elderly, a comprehensive model that integrates various brain pathologies is still lacking.METHODSWe used data from 528 non‐demented older adults with or without sarcopenia in the Catholic Aging Brain Imaging (CABI) database, containing magnetic resonance imaging scans, positron emission tomography scans, and clinical data. We also measured three key components of sarcopenia: skeletal muscle index (SMI), hand grip strength (HGS), and the five times sit‐to‐stand test (5STS).RESULTSAll components of sarcopenia were significantly correlated with global cognitive function, but cortical thickness and amyloid‐beta (Aβ) retention had distinctive relationships with each measure. In the path model, brain atrophy resulting in cognitive impairment was mediated by Aβ retention for SMI and periventricular white matter hyperintensity for HGS, but directly affected by the 5STS.DISCUSSIONTreatments targeting each sub‐domain of sarcopenia should be considered to prevent cognitive decline.Highlights
We identified distinct impacts of three sarcopenia measures on brain structure and Aβ.
Muscle mass is mainly associated with Aβ and has an influence on the brain atrophy.
Muscle strength linked with periventricular WMH and brain atrophy.
Muscle function associated with cortical thinning in specific brain regions.
Interventions on sarcopenia may be important to ease cognitive decline in the elderly.
Systemic immune response of burns from the acute to chronic phase
Authors: Osuka Akinori , Shigeno Ayami , Matsuura Hiroshi , Onishi Shinya , Yoneda Kazuhiro 
Published: June 2024

AbstractImmune responses that occur following burn injury comprise a series of reactions that are activated in response to damaged autologous tissues, followed by removal of damaged tissues and foreign pathogens such as invading bacteria, and tissue repair. These immune responses are considered to be programmed in living organisms. Developments of modern medicine have led to the saving of burned patients who could not be cured previously; however, the programmed response is no longer able to keep up, and various problems have arisen. This paper describes the mechanism of immune response specific to burn injury and the emerging concept of persistent inflammation, immunosuppression, and catabolism syndrome.
Photoswitchable Carbamazepine Analogs for Non‐Invasive Neuroinhibition In Vivo
Authors: Camerin Luisa , Maleeva Galyna , Gomila Alexandre M. J. , Suárez‐Pereira Irene , Matera Carlo , Prischich Davia , Opar Ekin , Riefolo Fabio , Berrocoso Esther , Gorostiza Pau 
Published: June 2024

AbstractA problem of systemic pharmacotherapy is off‐target activity, which causes adverse effects. Outstanding examples include neuroinhibitory medications like antiseizure drugs, which are used against epilepsy and neuropathic pain but cause systemic side effects. There is a need of drugs that inhibit nerve signals locally and on‐demand without affecting other regions of the body. Photopharmacology aims to address this problem with light‐activated drugs and localized illumination in the target organ. Here, we have developed photoswitchable derivatives of the widely prescribed antiseizure drug carbamazepine. For that purpose, we expanded our method of ortho azologization of tricyclic drugs to meta/para and to N‐bridged diazocine. Our results validate the concept of ortho cryptoazologs (uniquely exemplified by Carbazopine‐1) and bring to light Carbadiazocine (8), which can be photoswitched between 400–590 nm light (using violet LEDs and halogen lamps) and shows good drug‐likeness and predicted safety. Both compounds display photoswitchable activity in vitro and in translucent zebrafish larvae. Carbadiazocine (8) also offers in vivo analgesic efficacy (mechanical and thermal stimuli) in a rat model of neuropathic pain and a simple and compelling treatment demonstration with non‐invasive illumination.
Multiple Chirality Switching of a Dye‐Grafted Helical Polymer Film Driven by Acid & Base
Authors: Shi Aiyan , Wang Haoran , Yang Guojian , Gu Chang , Xiang Chaoyu , Qian Lei , Lam Jacky W. Y. , Zhang Ting , Tang Ben Zhong 
Published: June 2024

AbstractA stimuli‐responsive multiple chirality switching material, which can regulate opposed chiral absorption characteristics, has great application value in the fields of optical modulation, information storage and encryption, etc. However, due to the rareness of effective functional systems and the complexity of material structures, developing this type of material remains an insurmountable challenge. Herein, a smart polymer film with multiple chirality inversion properties was fabricated efficiently based on a newly‐designed acid & base‐sensitive dye‐grafted helical polymer. Benefited from the cooperative effects of various weak interactions (hydrogen bonds, electrostatic interaction, etc.) under the aggregated state, this polymer film exhibited a promising acid & base‐driven multiple chirality inversion property containing record switchable chiral states (up to five while the solution showed three‐state switching) and good reversibility. The creative exploration of such a multiple chirality switching material can not only promote the application progress of current chiroptical regulation technology, but also provide a significant guidance for the design and synthesis of future smart chiroptical switching materials and devices.
Ultra‐Fast Selenol‐Yne Click (SYC) Reaction Enables Poly(selenoacetal) Covalent Adaptable Network Formation
Authors: Zhang Mengyao , Chen Sisi , Xu Guichuan , Lu Weihong , Li Jiajia , Zhang Jiandong , Zhang Zhengbiao , Zhu Jian , Pan Xiangqiang 
Published: June 2024

AbstractThe emergence of covalent adaptable networks (CANs) based on dynamic covalent bonds (DCBs) presents a promising avenue for achieving resource recovery and utilization. In this study, we discovered a dynamic covalent bond called selenacetal, which is obtained through a double click reaction between selenol and activated alkynes. Density functional theory (DFT) calculations demonstrated that the ΔG for the formation of selenoacetals ranges from 12 to 18 kJ mol−1, suggesting its potential for dynamic reversibility. Dynamic exchange experiments involving small molecules and polymers provide substantial evidence supporting the dynamic exchange properties of selenoacetals. By utilizing this highly efficient click reaction, we successfully synthesized dynamic materials based on selenoacetal with remarkable reprocessing capabilities without any catalysts. These materials exhibit chemical recycling under alkaline conditions, wherein selenoacetal (SA) can decompose into active enone selenide (ES) and diselenides. Reintroducing selenol initiates a renewed reaction with the enone selenide, facilitating material recycling and yielding a newly developed dynamic material exhibiting both photo‐ and thermal responsiveness. The results underscore the potential of selenoacetal polymers in terms of recyclability and selective degradation, making them a valuable addition to conventional covalent adaptable networks.
Clustering‐Resistant Cu Single Atoms on Porous Au Nanoparticles Supported by TiO2 for Sustainable Photoconversion of CO2 into CH4
Authors: Xie Zhongkai , Li Longhua , Gong Shanhe , Xu Shengjie , Luo Hongyun , Li Di , Chen Hongjing , Chen Min , Liu Kuili , Shi Weidong , Xu Dongbo , Lei Yong 
Published: June 2024

AbstractPhotocatalysts based on single atoms (SAs) modification can lead to unprecedented reactivity with recent advances. However, the deactivation of SAs‐modified photocatalysts remains a critical challenge in the field of photocatalytic CO2 reduction. In this study, we unveil the detrimental effect of CO intermediates on Cu single atoms (Cu‐SAs) during photocatalytic CO2 reduction, leading to clustering and deactivation on TiO2. To address this, we developed a novel Cu‐SAs anchored on Au porous nanoparticles (CuAu‐SAPNPs‐TiO2) via a vectored etching approach. This system not only enhances CH4 production with a rate of 748.8 μmol ⋅ g−1 ⋅ h−1 and 93.1 % selectivity but also mitigates Cu‐SAs clustering, maintaining stability over 7 days. This sustained high performance, despite the exceptionally high efficiency and selectivity in CH4 production, highlights the CuAu‐SAPNPs‐TiO2 overarching superior photocatalytic properties. Consequently, this work underscores the potential of tailored SAs‐based systems for efficient and durable CO2 reduction by reshaping surface adsorption dynamics and optimizing the thermodynamic behavior of the SAs.