bluuebunny/crossref_metadata_2025_split huggingface dataset:
Four weeks of off‐treatment follow‐up is sufficient to determine virologic responses at off‐treatment week 12 in patients with hepatitis C virus infection receiving fixed‐dose pangenotypic direct‐acting antivirals
Authors: Liu Chen‐Hua , Chang Yu‐Ping , Lee Ji‐Yuh , Chen Chi‐Yi , Kao Wei‐Yu , Lin Chih‐Lin , Yang Sheng‐Shun , Shih Yu‐Lueng , Peng Cheng‐Yuan , Lee Fu‐Jen , Tsai Ming‐Chang , Huang Shang‐Chin , Su Tung‐Hung , Tseng Tai‐Chung , Liu Chun‐Jen , Chen Pei‐Jer , Kao Jia‐Horng 
Published: May 2024

AbstractEarly confirmation of sustained virologic response (SVR) or viral relapse after direct‐acting antivirals (DAAs) for hepatitis C virus (HCV) infection is essential based on public health perspectives, particularly for patients with high risk of nonadherence to posttreatment follow‐ups. A total of 1011 patients who achieved end‐of‐treatment virologic response, including 526 receiving fixed‐dose pangenotypic DAAs, and 485 receiving other types of DAAs, who had available off‐treatment weeks 4 and 12 serum HCV RNA data to confirm SVR at off‐treatment week 12 (SVR12) or viral relapse were included. The positive predictive value (PPV) and negative predictive value (NPV) of SVR4 to predict patients with SVR12 or viral relapse were reported. Furthermore, we analyzed the proportion of concordance between SVR12 and SVR24 in 943 patients with available SVR24 data. The PPV and NPV of SVR4 to predict SVR12 were 98.5% (95% confidence interval [CI]: 98.0–98.9) and 100% (95% CI: 66.4–100) in the entire population. The PPV of SVR4 to predict SVR12 in patients receiving fixed‐dose pangenotypic DAAs was higher than those receiving other types of DAAs (99.8% [95% CI: 98.9–100] vs. 97.1% [95% CI: 96.2–97.8], p < 0.001). The NPVs of SVR4 to predict viral relapse were 100%, regardless of the type of DAAs. Moreover, the concordance between SVR12 and SVR24 was 100%. In conclusion, an off‐treatment week 4 serum HCV RNA testing is sufficient to provide an excellent prediction power of SVR or viral relapse at off‐treatment week 12 among patients with HCV who are treated with fixed‐dose pangenotypic DAAs.
Automated Scoring of Scientific Creativity in German
Authors: Goecke Benjamin , DiStefano Paul V. , Aschauer Wolfgang , Haim Kurt , Beaty Roger , Forthmann Boris 
Published: May 2024

ABSTRACTAutomated scoring is a current hot topic in creativity research. However, most research has focused on the English language and popular verbal creative thinking tasks, such as the alternate uses task. Therefore, in this study, we present a large language model approach for automated scoring of a scientific creative thinking task that assesses divergent ideation in experimental tasks in the German language. Participants are required to generate alternative explanations for an empirical observation. This work analyzed a total of 13,423 unique responses. To predict human ratings of originality, we used XLM‐RoBERTa (Cross‐lingual Language Model‐RoBERTa), a large, multilingual model. The prediction model was trained on 9,400 responses. Results showed a strong correlation between model predictions and human ratings in a held‐out test set (n = 2,682; r = 0.80; CI‐95% [0.79, 0.81]). These promising findings underscore the potential of large language models for automated scoring of scientific creative thinking in the German language. We encourage researchers to further investigate automated scoring of other domain‐specific creative thinking tasks.
The impact of continuity correction methods in Cochrane reviews with single‐zero trials with rare events: A meta‐epidemiological study
Authors: Tsujimoto Yasushi , Tsutsumi Yusuke , Kataoka Yuki , Shiroshita Akihiro , Efthimiou Orestis , Furukawa Toshi A. 
Published: May 2024

AbstractMeta‐analyses examining dichotomous outcomes often include single‐zero studies, where no events occur in intervention or control groups. These pose challenges, and several methods have been proposed to address them. A fixed continuity correction method has been shown to bias estimates, but it is frequently used because sometimes software (e.g., RevMan software in Cochrane reviews) uses it as a default. We aimed to empirically compare results using the continuity correction with those using alternative models that do not require correction. To this aim, we reanalyzed the original data from 885 meta‐analyses in Cochrane reviews using the following methods: (i) Mantel–Haenszel model with a fixed continuity correction, (ii) random effects inverse variance model with a fixed continuity correction, (iii) Peto method (the three models available in RevMan), (iv) random effects inverse variance model with the treatment arm continuity correction, (v) Mantel–Haenszel model without correction, (vi) logistic regression, and (vii) a Bayesian random effects model with binominal likelihood. For each meta‐analysis we calculated ratios of odds ratios between all methods, to assess how the choice of method may impact results. Ratios of odds ratios <0.8 or <1.25 were seen in ~30% of the existing meta‐analyses when comparing results between Mantel–Haenszel model with a fixed continuity correction and either Mantel–Haenszel model without correction or logistic regression. We concluded that injudicious use of the fixed continuity correction in existing Cochrane reviews may have substantially influenced effect estimates in some cases. Future updates of RevMan should incorporate less biased statistical methods.
Zein/fucoidan‐coated phytol nanoliposome: preparation, characterization, physicochemical stability, in vitro release, and antioxidant activity
Authors: Chen Yadan , Wang Yanbin , He Liang , Wang Liling , Zhao Jianchen , Yang Zhenya , Li Qin , Shi Rui 
Published: May 2024

AbstractBACKGROUNDTo improve phytol bioavailability, a novel method of magnetic stirring and high‐pressure homogenization (HPH) combination was used to prepare zein/fucoidan‐coated phytol nanoliposomes (P‐NL‐ZF). The characterization, the simulated in vitro digestion, and the antioxidant activity of these phytol nanoliposomes from the different processes have been studied.RESULTSBased on the results of dynamic light scattering (DLS) and gas chromatography–mass spectrometer (GC–MS) analysis, P‐NL‐ZF prepared through the combination of magnetic stirring and HPH exhibited superior encapsulation efficiency at 76.19% and demonstrated exceptional physicochemical stability under a series of conditions, including storage, pH, and ionic in comparison to single method. It was further confirmed that P‐NL‐ZF by magnetic stirring and HPH displayed a uniform distribution and regular shape through transmission electron microscopy (TEM). Fourier‐transform infrared (FTIR) spectroscopy and differential scanning calorimetry (DSC) analysis showed that electrostatic interactions and hydrogen bonding were the primary driving forces for the formation of composite nanoliposomes. Additionally, an in vitro digestion study revealed that multilayer composite nanoliposomes displayed significant and favorable slow‐release properties (58.21%) under gastrointestinal conditions compared with traditional nanoliposomes (82.36%) and free phytol (89.73%). The assessments of chemical and cell‐based antioxidant activities demonstrated that the coating of zein/fucoidan on phytol nanoliposomes resulted in enhanced effectiveness in scavenging activity of ABTS free radical and hydroxyl radical and mitigating oxidative damage to HepG2 cells.CONCLUSIONBased on our studies, the promising delivery carrier of zein/fucoidan‐coated nanoliposomes is contributed to the encapsulation of hydrophobic natural products and enhancement of their biological activity. © 2024 Society of Chemical Industry.
Accurate tibial tunnel position in transtibial pullout repair for medial meniscus posterior root tears delays the progression of medial joint space narrowing
Authors: Kawada Koki , Okazaki Yuki , Tamura Masanori , Yokoyama Yusuke , Ozaki Toshifumi , Furumatsu Takayuki 
Published: May 2024

AbstractPurposeThis study aimed to evaluate the association between the progression of medial joint space (MJS) narrowing, medial meniscus extrusion (MME) and clinical scores and the tibial tunnel position in pullout repairs for medial meniscus posterior root tears (MMPRTs).MethodsThis retrospective study examined 54 patients. Changes in MJS (ΔMJS), MME (ΔMME) and clinical scores and their relationship with the tibial tunnel position were evaluated using correlation coefficients. The distance from the anatomical to technical attachment position in the tibial tunnel position was measured in the anterior and medial directions, and the direct distance was measured using the Pythagorean theorem.ResultsThe mean ΔMJS and ΔMME were 0.6 ± 0.8 and 1.3 ± 1.3 mm, respectively, and the mean anterior, medial and direct distances were 1.4 ± 2.3, 2.2 ± 1.7 and 3.4 ± 1.7 mm, respectively. ΔMJS had a significant positive correlation with the medial (r = 0.580, p < 0.001) and direct (r = 0.559, p < 0.001) distances, while ΔMME had a significant positive correlation with direct distance (r = 0.295, p = 0.030). Several clinical scores were significantly negatively correlated with these distances.ConclusionIn transtibial pullout repair for MMPRTs, accurate tibial tunnel position delayed the progression of MJS narrowing and MME, leading to improved clinical outcomes. The progression of MJS narrowing was associated with the mediolateral direction of the tibial tunnel position, while the clinical scores were associated with the anteroposterior direction of the tibial tunnel position. These findings indicate the need to orient the tip of the guide in a more posterolateral direction when creating the tibial tunnel.Level of EvidenceLevel IV.
The presence of a deep lateral femoral notch sign in ACL‐injured patients is associated with a 2.7° steeper posterior tibial slope and a 19% higher frequency of lateral meniscal injuries
Authors: Braz José N. P. da Silva Vilhena , Alves Luís F. T. G. , Ferreira Fábio A. L. , Barros António S. , de Sousa António M. S. N. , Gutierres Manuel A. P. 
Published: May 2024

AbstractPurposeThe purpose of this study was to study the relationship between the presence of a deep lateral femoral notch sign (DLFNS) in anterior cruciate ligament (ACL)‐injured patients and a higher posterior lateral tibial slope (LPTS), a reduced meniscal bone angle (MBA), a higher LPTS/MBA ratio and a higher incidence of concomitant injuries in primary ACL tears.MethodsA retrospective case‐control study was performed in patients submitted to primary ACL reconstruction with an available preoperative magnetic resonance imaging (MRI) scan. Patients with ACL tears and a femoral impactation with a depth ≥2 mm were assorted to the DLFNS group and patients with ACL tear and without a DLFNS to the control group. LPTS and MBA were measured in MRI. The presence of concomitant injuries (meniscal, posterior cruciate ligament, medial collateral ligament, lateral collateral ligament and bone injuries) was assessed in MRI. Quantitative data are presented in the median ± interquartile range (IQR).ResultsThere were 206 patients included in the study, with 46 patients assorted to the DLFNS group and 160 patients to the control group. In the DLFNS group, the median LPTS was 6.7° (IQR: 4.0–8.2) versus 4.0° in the control group (IQR: 2.2–6.5) (p = 0.003). The LPTS/MBA ratio was significantly higher in the DLFNS group, with a median of 0.32 (IQR: 0.19–0.44), in comparison to the control group, with a median of 0.19 (IQR: 0.11–0.31) (p < 0.001). The multivariable logistic regression analysis showed that the LPTS is an independent risk factor to having a DLFNS (odds ratio [OR] = 1.161; 95% confidence interval [CI]: 1.042–1.293, p = 0.007). There was a higher incidence of concomitant lateral meniscal injuries in the DLFNS group (67% vs. 48%, p = 0.017).ConclusionsIn patients with ACL tears, the presence of a DLFNS is associated with a steeper lateral posterior tibial slope, as well as a higher incidence of concomitant lateral meniscal injuries.Level of EvidenceLevel III.
Ameliorating saline‐sodic soils: A global meta‐analysis of field studies on the influence of exogenous amendments on crop yield
Authors: Wang Xiao , Ding Jianli , Wang Jinjie , Han Lijing , Tan Jiao , Ge Xiangyu 
Published: May 2024

AbstractAs the demand for food continues to rise, soil salinization and sodification pose an increasingly pressing challenge. Currently, there is a knowledge gap regarding how to effectively improve saline‐sodic soils to support sustainable agricultural production, especially the lack of systematic analysis on the effects of different amendments at a global scale. To address this gap, this study aims to explore the feasibility of using exogenous amendments to ameliorate saline‐sodic soils, conducting a global‐scale meta‐analysis based on 685 data pairs from 70 published studies. Our results showed that applying amendments to saline‐sodic soils significantly reduced electrical conductivity of saturated paste extract (ECe) by 33.0% and exchangeable sodium percentage (ESP) by 44.6%, while simultaneously increasing crop yield by 50.7%. Heterogeneity analysis further unveiled significant variations (p < 0.05) in the overall effect size, driven by factors such as initial soil properties (salinity and ESP levels), amendment type, climate and practical management conditions (application dose and experimental duration). The categorical variable analysis showed that, compared to soils with other salinization levels, the application of amendments in severe salinization soils was most effective in reducing soil ECe and enhancing crop yield. Considering the goals of mitigating soil salinity, sodicity, and increasing crop yield, the study suggests the application of mixed‐type amendments in practical settings. It is noteworthy that while extremely high doses (greater than 40 t ha−1) effectively increased crop yield, they also posed a risk of salt accumulation. In conclusion, this research offers critical insights for sustainable agriculture, guiding future work on soil health and food security in the context of global environmental challenges.
The windbreak effects of organic fence made from branches of Salix psammophila in Hobq Desert
Authors: Zhang Chao , Li Wanjiao , Cui Jian , Wang Peng , Tian Xiaoning , Dai Yuchen , Gao Yong , Qiu Guo Yu 
Published: May 2024

AbstractSalix sand barriers have been widely used in arid and semi‐arid regions of northern China as an environmentally friendly approach to control wind erosion. However, the inherent variability in length and thickness of Salix branches complicates achieving the desired fence porosity, typically resulting in an error of approximately 10% or more. This defect affects the fence's wind protection, thereby limiting their broader application. To address these challenges, we conducted a field experiment in the Hobq Desert, where we established Salix fences with porosities of 23%, 37%, and 44%, and measured the airflow velocities around these fences. The results indicated that the fence with 37% porosity exhibited the most effective sheltering effect, providing a protection distance up to 7.14 times of the fence height. A total of 44% porosity fences are also reasonably effective for practical purposes. On the other end of the spectrum, fences with 23% porosity demonstrated a better sediment interception than its high porosity peers, achieving an interception rate of 81.46%. Therefore, we conclude that organic fences made from Salix branches can serve as efficient windbreaks. Our findings provide foundational data for the application of organic fences in arid and semi‐arid regions of northern China, and potentially similar environments globally.
Deep Learning‐Driven Robust Glucose Sensing and Fruit Brix Estimation Using a Single Microwave Split Ring Resonator
Authors: Lee Seokho , Kim Kyungtae , Yang Younghwan , Seong Junhwa , Jung Chunghwan , Lee Hee‐Jo , Rho Junsuk 
Published: May 2024

AbstractExtracting the desired information from sensor data with various internal and external effects is a significant challenge in sensor applications. Difficult‐to‐control factors such as temperature, humidity, and sample position can significantly affect the stability and reliability of sensor data. In this paper, a deep learning‐based glucose sensing method that is robust to variations in sample position is proposed. It is shown that the variations in sample position affect the sensor data measured by the designed split ring resonator‐based microwave sensor. Then, artificial neural network and 1D convolutional neural network (CNN) models are evaluated for extracting glucose concentration information from the sensor data measured at random sample positions. The concentration of the glucose solution ranged from 1% to 23% (2% increments). The 1D CNN with all frequencies (0.5–18 GHz) of the and datasets outperformed the other model, with a mean absolute error (MAE) of 0.695% and a mean squared error (MSE) of 0.876 evaluated via cross‐validation. The study demonstrated that the sensor system can be applied in real life by performing fruit Brix estimation based on transfer learning of the previous 1D CNN network, and the MAE and MSE are 0.450% and 0.305, respectively.
Using Bayesian multispecies models to evaluate fish and invertebrate detection probability and distribution in the hypersaline Bahia Grande tidal basin
Authors: Ulibarri Roy M. , Eckert Catherine , Hicks David , Montagne Mike , Jones Brandon , Stewart David R. 
Published: May 2024

Abstract

Objective
In 2000, the Laguna Atascosa National Wildlife Refuge acquired the Bahia Grande (Texas) management unit, a space that had lain barren and arid for 70 years. A large cooperative partnership launched a restoration project to replenish the basin and recover its original tidal hydrology. In 2005, the construction of a pilot channel successfully restored water throughout the basin, and plans to eventually widen the channel were developed. Our study aims to evaluate an estuarine habitat restoration by assessing ecological drivers and the impacts on species diversity.

Methods
We evaluated species richness, detection/occupancy rates, and species–habitat relationships, and we estimated the sampling effort required to achieve a given level of relative precision if relative abundance was used instead of occupancy to inform future sampling. Sampling gear included bag seines for juvenile life stages and gill nets for capturing subadult and adult life stages. For analysis, we used a Bayesian negative binomial linear mixed-effects model to evaluate richness–habitat relationships and a hierarchical Bayesian multispecies model to evaluate individual species–habitat relationships, and we calculated the total number of fish captured and relative standard error by gear and sample year to produce a precise estimate of relative abundance.

Result
Overall, 29 species were caught between 2018 and 2021. Salinity emerged as a clear driver in the Bahia Grande, as both species richness and individual-level responses were negatively associated with high salinity values. We found that catch estimated as relative abundance had much variability, as is typical of most survey programs assuming constant detectability, and the number of net sets or seine hauls required to achieve a given level of relative precision varied considerably depending on the species, season, year, and gear type. The most collected species were found in the upper extremes of their salinity tolerances—potentially a unique adaptation to this hypersaline system.

Conclusion
Baseline data suggest that for the channel widening to be successful, there must be a noticeable increase in suitable habitat characteristics throughout the basin.
Fishing in muddy water? Climate policy uncertainty and corporate greenwashing in environmental, social, and governance
Authors: Zhang Zixuan , Ge Zhenyu 
Published: May 2024

AbstractThis study investigates the relationship between climate policy uncertainty and corporate greenwashing behavior using data from Chinese A‐share listed companies from 2009 to 2021. The results indicate that the increasing climate policy uncertainty significantly and robustly strengthens corporate greenwashing behavior, particularly among firms located in regions with weaker environmental regulations, within high‐polluting industries and with shorter‐term management perspectives. Additionally, the development and widespread adoption of digital technologies, along with enhanced external regulatory pressures, can inversely moderate the positive relationship between climate policy uncertainty and corporate greenwashing. In summary, this study contributes to our understanding of corporate behavior under climate risks and provides insights for achieving social sustainability.
A distributed algorithm with network‐independent step‐size and event‐triggered mechanism for economic dispatch problem
Authors: Chen Baitong , Yang Jianhua , Lu Wei , Pedrycz Witold , Sun Changhai 
Published: May 2024

AbstractThe economic dispatch problem (EDP) poses a significant challenge in energy management for modern power systems, particularly as these systems undergo expansion. This growth escalates the demand for communication resources and increases the risk of communication failures. To address this challenge, we propose a distributed algorithm with network‐independent step sizes and an event‐triggered mechanism, which reduces communication requirements and enhances adaptability. Unlike traditional methods, our algorithm uses network‐independent step sizes derived from each agent's local cost functions, thus eliminating the need for detailed network topology knowledge. The theoretical derivation identifies a range of step size values that depend solely on the objective function's strong convexity and the gradient's Lipschitz continuity. Furthermore, the proposed algorithm is shown to achieve a linear convergence rate, assuming the event triggering threshold criteria are met for linear convergence. Numerical experiments further validate the effectiveness and advantages of our proposed distributed algorithm by demonstrating its ability to maintain good convergence characteristics while reducing communication frequency.
Quality markers of Polygala fallax Hemsl decoction based on qualitative and quantitative analysis combined with network pharmacology and chemometric analysis
Authors: Li Yangling , Cheng Yanwei , Zhang Yingqi , Nan Huiling , Lin Ning , Chen Qing 
Published: May 2024

AbstractIntroductionPolygala fallax Hemsl (PFH) is a widely used herbal medicine in Guangxi, China. At present, research on PFH mainly focuses on extraction technology and cultivation, lacking quality control standards for systematic evaluation.ObjectivesThe study aimed to assess the quality of PFH from different sources and to predict markers that would help assess quality.MethodsFingerprinting of 15 batches of PFH samples was performed by ultra‐high performance liquid chromatography (UPLC) and similarity was assessed using hierarchical cluster analysis (HCA), principal component analysis (PCA), and orthogonal partial least squares discrimination (OPLS‐DA). Differential components were screened by mathematical analysis, and a “component‐target‐pathway” network map was constructed in combination with network pharmacology, quality markers (Q‐markers) of PFH were predicted, and quantitative analysis was performed.ResultsFifteen batches were fingerprinted for PFH, with 11 common peaks, and peak 5 was identified as 4‐hydroxybenzoic acid, which was generally consistent with the results of HCA, PCA, and OPLS‐DA. Network pharmacology screened 18 potential compounds, 45 core targets, and 20 key pathways, integrating fingerprinting, pattern recognition, and network pharmacology methods. One of the potential Q‐markers that can identify the principle of testability, efficacy, and specificity is 4‐hydroxybenzoic acid, whose content ranges from 0.0188 to 1.4517 mg/g.ConclusionThe potential Q‐markers of PFH were predicted by integrating fingerprinting, pattern recognition, and network pharmacological analysis, which provided a scientific basis for the overall control and evaluation of the quality of PFH and a theoretical reference for the study of the quality standard of multi‐base traditional Chinese medicine.