bluuebunny/crossref_metadata_2025_split huggingface dataset:
Multiple Zeta-Functions Associated with Linear Recurrence Sequences and the Vectorial Sum Formula
Authors: Essouabri Driss , Matsumoto Kohji , Tsumura Hirofumi 
Published: December 2010

Abstract We prove the holomorphic continuation of certain multi-variable multiple zeta-functions whose coefficients satisfy a suitable recurrence condition. In fact, we introduce more general vectorial zeta-functions and prove their holomorphic continuation. Moreover, we show a vectorial sum formula among those vectorial zeta-functions fromwhich some generalizations of the classical sum formula can be deduced.
Descemet Stripping Automated Endothelial Keratoplasty Combined with Phacoemulsification in Chandler Syndrome
Authors: Kymionis George D. , Kontadakis Georgios A. , Agorogiannis George I. , Bennett Merran , Angelidou Filio 
Published: December 2010

Purpose TO report a case of Descemet stripping automated endothelial keratoplasty (DSAEK) in combination with phacoemulsification and implantation of intraocular lens (IOL) (triple procedure) in a patient with Chandler syndrome. Methods A patient with visually significant corneal edema due to Chandler syndrome and cataract underwent DSAEK combined with phacoemulsification and IOL implantation (DSAEK triple procedure). Results One year postsurgery the patient's uncorrected distance visual acuity improved from counting fingers to 20/63, and the corrected distance visual acuity to 20/32. The cornea was clear with absence of corneal edema. Conclusions In the presented case, DSAEK triple procedure was an effective treatment for corneal edema secondary to Chandler syndrome in the presence of cataract.
Interstitial deletion of 14q24.3‐q32.2 in a male patient with plagiocephaly, BPES features, developmental delay, and congenital heart defects
Authors: Cingöz Sultan , Bache Iben , Bjerglund Lise , Ropers Hans‐Hilger , Tommerup Niels , Jensen Hanne , Brøndum‐Nielsen Karen , Tümer Zeynep 
Published: December 2010

AbstractDistal interstitial deletions of chromosome 14 involving the 14q24‐q23.2 region are rare, and only been reported so far in 20 patients. Ten of these patients were analyzed both clinically and genetically. Here we present a de novo interstitial deletion of chromosome 14q24.3‐q32.2 in a male patient with developmental delay, language impairment, plagiocephaly, BPES features (blepharophimosis, ptosis, epicanthus), and congenital heart defect. The deletion breakpoints were fine mapped using fluorescence in situ hybridization (FISH) and the size of the deletion is estimated to be approximately 23 Mb. Based on genotype–phenotype comparisons of the 10 previously published patients and the present case, we suggest that the shortest regions for deletion overlap may include candidate genes for speech impairment, mental retardation, and hypotonia. © 2010 Wiley‐Liss, Inc.
Muenke syndrome with pigmentary disorder and probable hemimegalencephaly: An expansion of the phenotype
Authors: Abdel‐Salam Ghada M. H. , Flores‐Sarnat Laura , El‐Ruby Mona O. , Parboosingh Jillian , Bridge Peter , Eid Maha M. , El‐Badry Tarek H. , Effat Laila , Curatolo Paolo , Temtamy Samia A. 
Published: December 2010

AbstractWe describe a 2‐year‐old boy born to healthy, consanguineous parents. He had craniofacial asymmetry with left frontal bossing, midface hypoplasia, proptosis, and low‐set ears. In addition, he had curly, light hair, and oval hypomelanotic patches in the abdomen, lower limbs and back and one hyperpigmented patch in the groin without acanthosis nigricans. Cranial three‐dimensional CT scan showed right‐coronal, sagittal, and lambdoid suture synostoses. His cranial MRI at 2‐months of age showed left hemimegalencephaly, hypoplasia of corpus callosum, and an abnormal configuration of hippocampus. In spite of these cranial findings, he had mild developmental delay and his neurological examination showed symmetric strength, tone and reflexes. Apart from febrile seizures, there was no history of epilepsy. The proband developed asymmetric hydrocephalus at the age of 18 months that required third ventriculostomy. Post‐operative cranial MRI showed Chiari I‐ like malformation and asymmetry of cerebral hemispheres but less dysplastic cerebral cortex. Mutation analysis of FGFR3 showed a c.749C > G, p.Pro250Arg substitution. To the best of our knowledge, these manifestations have not been reported in patients with Muenke syndrome. © 2010 Wiley‐Liss, Inc.
IGF1R variants associated with isolated single suture craniosynostosis
Authors: Cunningham Michael L. , Horst Jeremy A. , Rieder Mark J. , Hing Anne V. , Stanaway Ian B. , Park Sarah S. , Samudrala Ram , Speltz Matthew L. 
Published: December 2010

AbstractThe genetic contribution to the pathogenesis of isolated single suture craniosynostosis is poorly understood. The role of mutations in genes known to be associated with syndromic synostosis appears to be limited. We present our findings of a candidate gene resequencing approach to identify rare variants associated with the most common forms of isolated craniosynostosis. Resequencing of the coding regions, splice junction sites, and 5′ and 3′ untranslated regions of 27 candidate genes in 186 cases of isolated non‐syndromic single suture synostosis revealed three novel and two rare sequence variants (R406H, R595H, N857S, P190S, M446V) in insulin‐like growth factor I receptor (IGF1R) that are enriched relative to control samples. Mapping the resultant amino acid changes to the modeled homodimer protein structure suggests a structural basis for segregation between these and other disease‐associated mutations found in IGF1R. These data suggest that IGF1R mutations may contribute to the risk and in some cases cause single suture craniosynostosis. © 2010 Wiley‐Liss, Inc.
Two concurrent chromosomal aberrations involving interstitial deletion in 1q24.2q25.2 and inverted duplication and deletion in 10q26 in a patient with stroke associated with antithrombin deficiency and a patent foramen ovale
Authors: Kibe Tetsuya , Mori Yuka , Okanishi Tohru , Shimojima Keiko , Yokochi Kenji , Yamamoto Toshiyuki 
Published: December 2010

AbstractAdvanced high‐throughput molecular cytogenetic analysis has enabled the identification of small chromosomal rearrangements, and two or more concurrently occurring chromosomal rearrangements have been identified using this technique. A girl with severe psychomotor developmental delay associated with an uncertain abnormality (detected by conventional karyotyping) in chromosome 10q had a sudden stroke at the age of 35 months. Laboratory and radiographic examinations revealed antithrombin (AT) deficiency and a patent foramen ovale (PFO). Two concurrent chromosomal aberrations, inverted duplication and deletion in the 10q26 region and a microdeletion in the 1q24.2q25.2 region including the AT gene (SERPINC1), were identified by microarray‐based comparative genomic hybridization analysis. Both chromosomal aberrations were found to be of paternal origin. This study described the concurrence of chromosomal rearrangements involving two chromosomes, and estimated the frequency of two or more chromosomal aberrations as 2–4%. © 2010 Wiley‐Liss, Inc.
Neurologic features and genotype‐phenotype correlation in Wolfram syndrome
Authors: Chaussenot Annabelle , Bannwarth Sylvie , Rouzier Cecile , Vialettes Bernard , Mkadem Samira Ait El , Chabrol Brigitte , Cano Aline , Labauge Pierre , Paquis‐Flucklinger Véronique 
Published: December 2010

AbstractObjectiveWolfram syndrome (WS) is a rare neurodegenerative disorder characterized by juvenile‐onset diabetes mellitus and optic atrophy. Our aim was to describe the nature and the frequency of the neurologic manifestations, which had been poorly studied until now.MethodsWe performed a detailed clinical study with genotype‐phenotype correlation in a series of 59 patients with WS.ResultsThe onset of neurologic symptoms, with a median age of 15 years, was much earlier than previously reported. Cognitive impairment, which was not frequent in previous reports, was observed in 32% of patients with neurologic signs. Like epilepsy, it was mainly found in patients who developed neurologic signs before 15 years of age. In contrast to previous series, we also found malformations of cortical development on magnetic resonance imaging in epileptic children and white matter involvement, including diffuse leukoencephalopathy, in adult patients. We identified 109 mutated alleles corresponding to 56 different mutations of the WFS1 gene, among which 10 were novel. Homozygosity or compound heterozygosity for missense mutation does not seem to influence the age of onset and the occurrence of neurologic complications. However, an interesting point concerns a possible correlation between the location of the mutations and the development of the neurologic manifestations.InterpretationThis series concerns the largest cohort of WS patients reported to date. It illustrates the wide variety of neurologic signs in this syndrome and the necessity of rapid therapeutic coverage to improve the prognosis. Ann Neurol 2010.
Experimentelle Überprüfung der Tragsicherheit von Stahlbetonrippendecken
Authors: Opitz Heinz , Hampel Torsten , Michler Harald , Popp Thomas , Scheerer Silke 
Published: December 2010

AbstractVor zehn Jahren wurde die Richtlinie des Deutschen Ausschusses für Stahlbeton (DAfStb) “Belastungsversuche an Betontragwerken” veröffentlicht [1]. Die nachfolgend vorgestellten Untersuchungen, die an einer Deckenkonstruktion eines 1958 errichteten Bauwerks der TU Dresden durchgeführt wurden, sind nur ein Beispiel der mittlerweile zahlreichen Anwendungen dieser Richtlinie. Gründe für den Nachweis der aktuellen Trag sicherheit der Stahlbetonrippendecke waren die geplante Umnutzung einiger Räume, der gegenwärtige bauliche Zustand, der berechtigte Zweifel hinsichtlich Tragfähigkeit, Gebrauchstauglichkeit und Brandschutz aufwarf, und die vorausgegangenen statischen Berechnungen des Tragwerksplaners vom Ingenieurbüro KÖRNER + HACKEL (Dresden).Experimental verification of load bearing capacity of reinforced concrete ribbed slabs. Ten years ago the guideline of the Deutscher Ausschuss für Stahlbeton (DAfStb) “Loading tests on concrete structures” was published [1]. The following proposed studies that were conducted on a reinforced concrete ribbed slab construction of a structure built in 1958 at the TU Dresden are just one example of the now numerous applications of this guideline. Reasons for the detection of the current structural safety of the slab construction were the planned conversion of some rooms, the current structural condition, doubts over capacity, performance and fire protection and the previous structural analysis of the consulting engineers from KÖRNER + HACKEL (Dresden).
Firmen und Verbände: Bautechnik 1/2011
Authors: lsselmann Kari‐Heinz , Gürpinar Hasan 
Published: December 2010

AbstractNachhaltigkeitsanforderungen in den Planungs‐ und Bauablauf integrieren — Bericht zu einer Veranstaltung an der RWTH AachenGeorg‐Donges‐Förderpreis verliehen
In vitro labeling of hydroxyapatite minerals by an engineered protein
Authors: Yuca Esra , Karatas Ayten Yazgan , Seker Urartu Ozgur Safak , Gungormus Mustafa , Dinler‐Doganay Gizem , Sarikaya Mehmet , Tamerler Candan 
Published: December 2010

AbstractBiological and biomimetic synthesis of inorganics have been a major focus in hard tissue engineering as well as in green processing of advanced materials. Among the minerals formed by organisms, calcium phosphate mineralization is studied extensively to understand the formation of mineral‐rich tissues. Herein, we report an engineered fusion protein that not only targets calcium phosphate minerals but also allows monitoring of biomineralization. To produce the bi‐functional fusion protein, nucleotide sequence encoding combinatorially selected hydroxyapatite‐binding peptides (HABP) was genetically linked to the 3′ end of the open reading frame of green fluorescence protein (GFPuv) and successfully expressed in Escherichia coli. The fluorescence and binding activities of the bi‐functional proteins were characterized by, respectively, using fluorescence microscopy and quartz crystal microbalance spectroscopy. The utility of GFPuv‐HABP fusion protein was assessed for both time‐wise monitoring of mineralization and the visualization of the mineralized tissues. We used an alkaline phosphatase‐based reaction to control phosphate release, thereby mimicking biological processes, to monitor calcium phosphate mineralization. The increase in mineral amount was observed using the fusion protein at different time points. GFPuv‐HABP1 was also used for efficient fluorescence labeling of mineralized regions on the extracted human incisors. Our results demonstrate a simple and versatile application of inorganic‐binding peptides conjugated with bioluminescence proteins as bi‐functional bioimaging molecular probes that target mineralization, and which can be employed to a wide range of biomimetic processing and cell‐free tissue engineering. Bioeng. 2011; 108:1021–1030. © 2010 Wiley Periodicals, Inc.
Biological analysis of herbal medicines used for the treatment of liver diseases
Authors: Chien Chao‐Feng , Wu Yu‐Tse , Tsai Tung‐Hu 
Published: December 2010

AbstractHerbal medicines have been used to treat liver disorders for thousands of years in the East and have now become a promising therapy internationally for pathological liver conditions. Biological analysis of hepatoprotective herbs is an important issue from the pharmacokinetic perspective in developing new therapeutic managements for liver disease. The biological analysis focuses on the pretreatment methods, separation and quantification of herbal medicines in biological samples. We have compiled and discuss the biological analytical method of six herbal medicines for liver protection containing Silybum marianum(silymarin), Glycyrrhiza glabra, Scutellaria baicalensis, Schisandra chinensis, Salvia miltiorrhiza and Astragalus membranaceus. This review provides a convenient reference for researchers to reduce time‐consuming method optimization. Copyright © 2010 John Wiley & Sons, Ltd.
Oxygen reduction electrode in advanced chlor‐alkali with ruthenium as electro‐catalyst
Authors: Joudaki E. , Hashemi S. J. , Mohammadi F. , Yousefi A. , Eivazkhani M. 
Published: December 2010

AbstractThe platinum (Pt) diffusion gas electrodes are frequently used in chlor‐alkali process industry. The platinum (Pt) diffusion gas electrodes used in advanced chlor‐alkali process has encountered many disadvantages such as flooding, which is the result of peroxide production phenomenon. The flooding reduces the process efficiency. In this article new electrodes are used to overcome some of the above‐mentioned disadvantages to increase efficiency. The effects of seven process parameters are also individually studied. The results show the brine concentration increase CCE by increasing, anolyte, oxygen temperatures, and flow rates. The brine concentration decreases as the current density increases. The Ru/C catalyst performance is higher than Pt/C catalyst. Besides, Ru effectively prevents the aggregation and growth of platinum nano‐particles in the thermal heating process. The higher activity, good stability, and the better caustic current efficiency of the Ru/C catalyst make it more suitable cathode in advanced chlor‐alkali process.
Fluidization and hydraulic behaviour of natural zeolite particles used for removal of contaminants from wastewater
Authors: Gallant J. , Prakash A. , Hogg LuVerne E. W. 
Published: December 2010

AbstractFluidization, bed expansion, pressure drop, and hydraulic characteristics of beds of natural zeolite particles have been studied for their potential application in the treatment of aqueous waste. The measurements in the bed of zeolite particles are compared with regular shaped glass beads. The bed of zeolite particles required to be fully fluidized before getting reproducible pressure measurements in the bed. This is attributed to their wider size distribution and resulting segregation. The mean size of the particles ranged from 550 to 900 µm. Minimum fluidization velocity was determined from pressure measurements below the distributor and compared with values from pressure measurements inside the bed. Experiments conducted with slurry out the bed showed that it could be easily drained in expanded mode from the column through a small diameter opening near the bottom.
Distribution and function of splash, an achaete‐scute homolog in the adult olfactory organ of the Caribbean spiny lobster Panulirus argus
Authors: Tadesse Tizeta , Schmidt Manfred , Walthall William W. , Tai Phang C. , Derby Charles D. 
Published: December 2010

Abstractachaete‐scute complex (ASC) genes, which encode basic helix‐loop‐helix transcription factors, regulate embryonic and adult neurogenesis in many animals. In adult arthropods, including crustaceans, ASC homologs have been identified but rarely functionally characterized. We took advantage of the recently identified crustacean homolog, splash (spiny lobster achaete scute homolog), in the olfactory organ of the Caribbean spiny lobster Panulirus argus to examine its role in adult neurogenesis. We tested the hypothesis that splash is associated with but not restricted to sensory neuron formation in the olfactory organ, the antennular lateral flagellum (LF), of adult spiny lobsters. We demonstrated splash labeling in epithelial cells across LF developmental zones (i.e., proliferation and mature zones), in auxiliary cells surrounding dendrites of olfactory receptor neurons (ORNs), and in immature and mature ORNs, but not in granulocytes or chromatophores. Since ORN proliferation varies with molt stage, we examined splash expression across molt stages and found that molt stage affected splash expression in the ORN mature zone but not in the proliferation zone. In vivo incorporation of bromodeoxyuridine (BrdU) showed no correlation in the cellular pattern of splash expression and BrdU labeling. The intensity of splash labeling was dramatically enhanced in the proliferation zones following LF damage, suggesting enhanced splash expression during repair and/or regeneration. We conclude that splash is not closely associated with the formation of sensory neurons under normal physiological conditions, and we propose that splash is involved in repair and regeneration. We also propose that splash has additional roles other than neurogenesis in adult crustaceans. © Wiley Periodicals, Inc. Develop Neurobiol 71: 316–335, 2011
Synthesis of a Small Library of Estradiol‐Based Glycosteroid Mimics Containing a Modified D‐Ring
Authors: Ekholm Filip S. , Schneider Gyula , Wölfling János , Leino Reko 
Published: December 2010

AbstractGlycosylated steroids, such as cardenolides and saponins, are widely distributed in nature and have been shown to possess various types of biological activities. In the present study, carbohydrate donors were evaluated for the glycosylation of steroids; the results show that benzoylated imidate donors were superior in terms of efficiency and operational simplicity. These donors were then applied to the synthesis of a limited library of estradiol‐based glycosteroid mimics containing a modified D‐ring. The deprotected molecules contained three types of variations in the steroid backbone and four types of variations in the sugar moiety. The synthesized structures will be screened for biological activity and for their potential use in drug delivery systems.
Reversible Aminal Formation: Controlling the Evaporation of Bioactive Volatiles by Dynamic Combinatorial/Covalent Chemistry
Authors: Buchs (née Levrand) Barbara , Godin Guillaume , Trachsel Alain , de Saint Laumer Jean‐Yves , Lehn Jean‐Marie , Herrmann Andreas 
Published: December 2010

AbstractDynamic mixtures generated by reversible aminal formation efficiently prolong the duration of evaporation of bioactive volatile aldehydes. Secondary diamines used for the generation of dynamic mixtures are obtained by treatment of primary diamines with carbonyl compounds and reduction of the diimines with NaBH4. The reversibilities of the reactions were demonstrated by NMR measurements in buffered aqueous solutions. Kinetic rate constants and equilibrium constants for the formation and hydrolysis of aminals were determined. The performance of dynamic mixtures as delivery systems for perfumery ingredients was tested after deposition onto cotton, and the long‐lastingness of fragrance evaporation was investigated by dynamic headspace analysis against a reference sample. The simplicity of the concept together with its excellent performance makes this delivery system highly interesting for applied perfumery. Reversible aminal formation might also be successfully applicable to dynamic combinatorial/covalent chemistry for screening of pharmaceutically or catalytically active ligands and receptors.
Optimal conditions for stability of photoemission and freeze drying of two luminescent bacteria for use in a biosensor
Authors: Camanzi Laura , Bolelli Luca , Maiolini Elisabetta , Girotti Stefano , Matteuzzi Diego 
Published: December 2010

Abstract
Bioluminescent bacteria have been used for many years for biotoxicological analysis. One of the main concerns with this microorganism is the low experimental repeatability when subjected to external factors. The aim of the present study was to obtain accurate, sensitive, and repeatable measurements with stable signals (during the detection and over days) for application in a water-analysis device for the detection of pollutants. Growth conditions were tested and optimized. An optimal freeze-drying procedure for the constitutive bioluminescent bacteria Vibrio fischeri and Photobacterium phosphoreum was developed. The luminescence stability after rehydration was also investigated. Freeze drying was found to be a critical process in survival and signal stability of luminescent bacteria; for this reason, different suspension fluids and various bacterial pellet/suspension fluid ratios (g/ml) were evaluated. The toxicity of heavy metals and organic compounds in water was determined to investigate the applicability of a test based on bacteria obtained in this way, comparing the data with legal limits. A scale-up process was developed with industrial technology: freeze-dried bacteria that emitted a stable luminous signal after rehydration were obtained. Moreover, the median effective concentration (EC50) was calculated with these bacteria. Environ. Toxicol. Chem. 2011; 30:801–805. © 2010 SETAC