bluuebunny/crossref_metadata_2025_split huggingface dataset:
Predicting podcast preference: An analysis framework and its application
Authors: Tsagkias Manos , Larson Martha , de Rijke Maarten 
Published: November 2009

AbstractFinding worthwhile podcasts can be difficult for listeners since podcasts are published in large numbers and vary widely with respect to quality and repute. Independently of their informational content, certain podcasts provide satisfying listening material while other podcasts have little or no appeal. In this paper we present PodCred, a framework for analyzing listener appeal, and we demonstrate its application to the task of automatically predicting the listening preferences of users. First, we describe the PodCred framework, which consists of an inventory of factors contributing to user perceptions of the credibility and quality of podcasts. The framework is designed to support automatic prediction of whether or not a particular podcast will enjoy listener preference. It consists of four categories of indicators related to the Podcast Content, the Podcaster, the Podcast Context, and the Technical Execution of the podcast. Three studies contributed to the development of the PodCred framework: a review of the literature on credibility for other media, a survey of prescriptive guidelines for podcasting, and a detailed data analysis. Next, we report on a validation exercise in which the PodCred framework is applied to a real‐world podcast preference prediction task. Our validation focuses on select framework indicators that show promise of being both discriminative and readily accessible. We translate these indicators into a set of easily extractable “surface” features and use them to implement a basic classification system. The experiments carried out to evaluate system use popularity levels in iTunes as ground truth and demonstrate that simple surface features derived from the PodCred framework are indeed useful for classifying podcasts.
An exploration of criminal thinking styles among civil psychiatric patients
Authors: Carr William Amory , Rosenfeld Barry , Magyar Melissa , Rotter Merrill 
Published: November 2009

AbstractBackground Several studies have found a relationship between psychiatric illness and criminal behaviour. Despite this, few studies have examined the presence of criminal thinking among civil psychiatric patients.Aims The aim of this study is to explore the patterns and correlates of criminal thinking, using the Psychological Inventory of Criminal Thinking Styles (PICTS), in a sample of civil psychiatric patients.Method The PICTS (Layperson Edition) and the Brief Psychiatric Rating Scale (Anchored Version; BPRS) were administered to 76 civil psychiatric patients. PICTS scores were compared with those of offenders from a previously published study. Bivariate tests were conducted between selected PICTS scales, BPRS factors, demographic and criminal history variables. Stepwise multiple regressions were performed to assess those variables that predicted the general criminal thinking, proactive and reactive composite scales of the PICTS.Results Independent samples t‐tests revealed that five PICTS thinking styles were significantly higher in the psychiatric sample compared with the comparison sample of criminal offenders. Bivariate correlations revealed that the PICTS proactive composite scale was significantly related to and predicted by substance abuse and arrest history.Conclusions/clinical implications: Thinking styles which are typically associated with criminality were found in this sample of civil psychiatric patients. Cognitive remediation strategies targeting these may help to prevent criminal activity in psychiatric patients. Copyright © 2009 John Wiley & Sons, Ltd.
Quartiles of Peak Troponin Are Associated with Long‐term Risk of Death in Type 1 and STEMI, but Not in Type 2 or NSTEMI Patients
Authors: Gonzalez Manuel A. , Porterfield Christopher P. , Eilen Dana J. , Marzouq Rana A. , Patel Hiren R. , Patel Amit A. , Nasir Summiyah , Lim Heang M. , Babb Joseph D. , Rose John D. , Cascio Wayne E. 
Published: November 2009

AbstractBackgroundThe prognostic value of peak cardiac troponin (cTn) in different types of acute myocardial infarction (AMI) under the universal clinical classification is unknown.HypothesisWe tested the hypothesis that the prognostic value of cTn varies with its peak level and type of AMI.MethodsWe studied 345 consecutive patients with AMI with mean follow‐up of 30.6 months according to quartiles of peak cTn level (QPTL) and the type of AMI. The study outcomes were the major adverse cardiovascular events (MACE; composite of all causes of mortality and recurrent AMI) and the individual components of MACE.ResultsThe study included patients with AMI Type 1 (n = 276), type 2 (n = 54), ST‐segment elevation myocardial infarction (STEMI; n = 159), and non‐ST‐segment elevation myocardial infarction (NSTEMI; n = 186). Overall, peak cTn level was an independent predictor of MACE (hazard ratio [HR]: 1.001, 95% confidence interval [CI]: 1.000–1.003, P = 0.01) and death (HR: 1.002, 95% CI: 1.001–1.004, P = 0.003), but not of recurrent AMI. The highest risk of MACE and death was in the highest QPTL (61.6%, P = .016 and 66.3%, P = 0.021, respectively) while the highest risk of recurrent AMI was in the lowest QPTL (83.7%, P = 0.04). Quartiles of peak cTn level were significantly associated with increased risk of MACE and death in patients with Type 1 (all P = 0.01) and STEMI (P = 0.01 and P = 0.02, respectively), but no association existed in type 2 or NSTEMI patients.ConclusionsOverall, peak cTn predicts the risk of MACE and death but not the risk of AMI. While in Type 1 and STEMI patients, QPTL are associated with risk of MACE and death, no association exists in type 2 or NSTEMI patients. Copyright © 2009 Wiley Periodicals, Inc.
Acute Chest Pain Evaluated by Coronary CT Angiography
Authors: Richard Conti C. 
Published: November 2009

AbstractMost of my time these days (at least 26 weeks out of every year) is spent on an inpatient cardiology service. Patients are general cardiology patients, mostly admitted from our emergency department (ED). Approximately half of these patients have a principle diagnosis of acute chest pain. Copyright © 2009 Wiley Periodicals, Inc.
Electrochemical Hydrogen Storage in Ti1.6V0.4Ni1−xCox Icosahedral Quasicrystalline Alloys
Authors: Hu Wen , Niu Xiao D. , Watada Masaharu , Kawabe Yoshiteru , Wu Yao M. , Wang Li D. , Wang Li M. 
Published: November 2009

AbstractThe discovery of the icosahedral phase (i‐phase) in rapidly quenched Ti1.6V0.4Ni1−xCox (x=0.02–0.1) alloys is described herein. The i‐phase occurs in a similar amount relative to the coexisting β‐Ti phase. The electron diffraction patterns show the distinct spot anisotropy, indicating that the i‐phase is metastable. The electrochemical hydrogen storage performances of these five alloy electrodes are also reported herein. The hydrogen desorption of nonelectrochemical recombination in the cyclic voltammetric (CV) response exhibits the demand for electrocatalytic activity improvement. A discharge capacity of 261.5 mA h g−1 was measured in a Ti1.6V0.4Ni0.96Co0.04 alloy electrode at 30 mA g−1 and 303 K and it is shown that an appropriate amount of Co element addition would enhance the cycling stability at the expense of high‐rate discharging ability.
Lactic acid in cancer and mitochondrial disease
Authors: Steliou Kosta , Perrine Susan P. , Faller Douglas V. 
Published: November 2009

AbstractCancer and the mitochondrial diseases are disparate disorders that have in common a failure of normal cellular respiratory activity in disease‐affected tissues. In mitochondrial diseases, the impairment in the mitochondria is often the result of abnormalities in their mtDNA, whereas in cancerous cells, the altered respiration is driven by the Warburg effect. The oxidation of glucose (as pyruvate in the mitochondria) is inhibited and energy production relies on cytoplasmic glycolysis. This suppressed mitochondrial activity confers in tumor cells a state of resistance to apoptosis and, in mitochondrial diseases like mitochondrial encephalopathy, lactic acidosis, and stroke‐like episodes (MELAS), the altered respiration leads to lactic acidosis. Driving glucose to its complete oxidation inside the mitochondria has potential in cancer therapy to reconstitute apoptotic competence in tumor cells and, in mitochondrial disease, to treat lactic acidosis. This minireview investigates the development of small molecule agents for suppressing the Warburg effect in cancer therapy and lactic acidosis in mitochondrial disease. Drug Dev Res 70:499–511, 2009. © 2009 Wiley‐Liss, Inc.
Response Behavior of Amperometric Glucose Biosensors Based on Different Carbon Substrate Transducers Coated with Enzyme‐Active Layer: A Comparative Study
Authors: Mauko Lea , Ogorevc Bozidar , Pihlar Boris 
Published: November 2009

AbstractCarbon electrodes (glassy carbon, GC, screen‐printed carbon, SPC, and carbon fiber, CF) were used as substrate transducers to prepare glucose biosensors of different sizes and geometries, based on iron‐ruthenium hexacyanoferrate as H2O2 reduction mediator and glucose oxidase immobilized in a poly(1,2‐phenylenediamine) membrane. Their response behavior under hydrodynamic amperometric conditions at an operating potential of −0.02 V vs. Ag/AgCl was studied and compared. While the GC and SPC based conventional size biosensors showed enzymatic catalysis controlled current response with nonlinear concentration dependence, the CF based micro‐biosensor exhibited, due to diffusion‐controlled current response, extended linear range calibration curves with relatively lower sensitivity and longer response times. Several preparation parameters responsible for the improvement of biosensor performance were also investigated.
Preparation and Properties of the Hybrid Material n‐Propyl(3‐methylpyridinium)silsesquioxane Chloride. Application in Electrochemical Determination of Nitrite
Authors: Magosso Hérica A. , Luz Rita C. S. , Gushikem Yoshitaka 
Published: November 2009

AbstractThe synthesis and properties of the ion exchange polymer 3‐n‐propyl(3‐methylpyridinium)silsesquioxane chloride (SiPy+Cl−) are described. Based on the Langmuir model, the equilibrium constant at the solid‐solution interface for the reaction, SiPy+Cl−+NO$\rm{{_{2}^{-}}}$⇌SiPy+NO$\rm{{_{2}^{-}}}$, was calculated for nitrite adsorption. The value found, β=8.7×103 L mol−1, indicates good affinity of the anion for the solid phase. A carbon paste electrode of the material was tested for NO$\rm{{_{2}^{-}}}$ oxidation and a linear response, in the concentration range between 6.3 and 143.6 μmol L−1, was obtained by amperometry. The analytical applicability of the proposed system was ascertained by the satisfactory results attained in its application to monitoring of nitrite in natural waters.
A Novel Glucose Biosensor Based on Glucose Oxidase Immobilized on AuPt Nanoparticle – Carbon Nanotube – Ionic Liquid Hybrid Coated Electrode
Authors: Zhang Yafen , Guo Gaiping , Zhao Faqiong , Mo Zhirong , Xiao Fei , Zeng Baizhao 
Published: November 2009

AbstractA novel amperometric glucose biosensor is presented in this article, which is based on the adsorption of glucose oxidase on gold‐platinum nanoparticle (AuPt NP)‐multiwalled carbon nanotube (MWNT) – ionic liquid (i.e., 1‐octyl‐3‐methylimidazolium hexafluorophosphate, [OMIM]PF6) composite. The gold‐platinum nanoparticles is prepared through direct electrodeposition. Owing to the synergistic action of AuPt nanoparticle, MWNT and [OMIM]PF6, the biosensor shows good response to glucose, with wide linear range (0.01 to 9.49 mM), short response time (3 s), and high sensitivity (3.47 μA mM−1). With the biosensor the determination of glucose in human serum is performed.
An Oxidizable Anion‐Excluding Polymer‐Overlayer for Oxygen Electrodes
Authors: Kang Chan , Cho Sangeun , Shin Hyosul , Heller Adam 
Published: November 2009

AbstractHere we describe an anion excluding ion‐permeable membrane, which we evaluate on an O2‐electroreducing cathode poised at a strongly oxidizing potential, near the reversible potential of the O2/H2O half cell. The bioelectrocatalyst of the O2 cathode consists of the cross‐linked electrostatic adduct of a polycationic redox hydrogel and bilirubin oxidase (BOD), a polyanion at neutral at pH 7.3. If an uncured Nafion dispersion is applied on this bioelectrocatalyst, the polyanionic Nafion displaces the BOD in the electrostatic adduct, de‐wiring the BOD. We show here that insertion of a polycationic poly(acrylamide‐co‐vinylimidazole) (PAA‐PVI) between the bioelectrocatalyst and the Nafion prevents the dewiring of BOD. The resulting bi‐layer membrane effectively excludes the urate, thiocyanate and NADH anions.
Real‐time imaging of single cancer‐cell dynamics of lung metastasis
Authors: Kimura Hiroaki , Hayashi Katsuhiro , Yamauchi Kensuke , Yamamoto Norio , Tsuchiya Hiroyuki , Tomita Katsuro , Kishimoto Hiroyuki , Bouvet Michael , Hoffman Robert M. 
Published: November 2009

AbstractWe have developed a new in vivo mouse model to image single cancer‐cell dynamics of metastasis to the lung in real‐time. Regulating airflow volume with a novel endotracheal intubation method enabled controlling lung expansion adequate for imaging of the exposed lung surface. Cancer cells expressing green fluorescent protein (GFP) in the nucleus and red fluorescent protein (RFP) in the cytoplasm were injected in the tail vein of the mouse. The right chest wall was then opened in order to image metastases on the lung surface directly. After each observation, the chest wall was sutured and the air was suctioned in order to re‐inflate the lung, in order to keep the mice alive. Observations have been carried out for up to 8 h per session and repeated up to six times per mouse thus far. The seeding and arresting of single cancer cells on the lung, accumulation of cancer‐cell emboli, cancer‐cell viability, and metastatic colony formation were imaged in real‐time. This new technology makes it possible to observe real‐time monitoring of cancer‐cell dynamics of metastasis in the lung and to identify potential metastatic stem cells. J. Cell. Biochem. 109: 58–64, 2010. © 2009 Wiley‐Liss, Inc.
Unwinding protein complexes in ALTernative telomere maintenance
Authors: Bhattacharyya Saumitri , Sandy April , Groden Joanna 
Published: November 2009

AbstractTelomeres are composed of specialized chromatin that includes DNA repair/recombination proteins, telomere DNA‐binding proteins and a number of three dimensional nucleic acid structures including G‐quartets and D‐loops. A number of studies suggest that the BLM and WRN recQ‐like helicases play important roles in recombination‐mediated mechanisms of telomere elongation or Alternative Lengthening of Telomeres (ALT), processes that maintain/elongate telomeres in the absence of telomerase. BLM and WRN localize within ALT‐associated nuclear bodies in telomerase‐negative immortalized cell lines and interact with the telomere‐specific proteins POT1, TRF1 and TRF2. Helicase activity is modulated by these interactions. BLM functions in DNA double‐strand break repair processes such as non‐homologous end joining, homologous recombination‐mediated repair, resolution of stalled replication forks and synthesis‐dependent strand annealing, although its precise functions at the telomeres are speculative. WRN also functions in DNA replication, recombination and repair, and in addition to its helicase domain, includes an exonuclease domain not found in other recQ‐like helicases. The biochemical properties of BLM and WRN are, therefore, important in biological processes other than DNA replication, recombination and repair. In this review, we discuss some previous and recent findings of human rec‐Q‐like helicases and their role in telomere elongation during ALT processes. J. Cell. Biochem. 109: 7–15, 2010. © 2009 Wiley‐Liss, Inc.
Nicotine, through upregulating pro‐survival signaling, cooperates with NNK to promote transformation
Authors: Nishioka Takashi , Guo Jinjin , Yamamoto Daisuke , Chen Lihua , Huppi Petra , Chen Chang Yan 
Published: November 2009

AbstractCigarette smoking is a mixture of thousands of compounds, many of which are carcinogens, such as NNK [4‐(methylnitrosamino)‐1‐(3‐pyridyl)‐1‐butanone]. Nicotine, as an addictive substance in cigarette, has been shown to promote growth of non‐neuronal cells. It is unclear how nicotine cooperates with tobacco‐related carcinogens during tumorigenesis. Here, by concurrent treatment of nicotine and NNK, we investigate the effect of the cooperation of these two compounds on cell growth and apoptosis in various different lung epithelial (RLE) or cancer (LKR) cells. We demonstrated that short‐term nicotine exposure moderately activated mitogenic signaling pathways (such as PKC, ERK, and Akt) and a mediocre protection against cisplatin‐mediated apoptosis. In contrast, NNK strongly stimulated mitogenic signaling and rendered the cells a high resistance to cisplatin. The pre‐ligation of nAChR by nicotine interfered with NNK‐mediated mitogenic signaling and resistance to cisplatin, the magnitude of which was similar as that exposed to nicotine alone. Interestingly, a week after the exposure to nicotine or nicotine plus NNK, Bcl‐2 expression was augmented, accompanied with the increased resistance to cisplatin‐induced apoptosis. In comparison, long‐term NNK treatment provided very little protection of the cells from cisplatin. We also showed that the combination treatment promoted more cells to grow in an anchorage‐independent fashion than NNK exposure alone. Thus, the data suggest that through occupying nAChR, nicotine appears to modulate NNK‐mediated signaling and persistently sustain pro‐survival activities to promote transformation. J. Cell. Biochem. 109: 152–161, 2010. © 2009 Wiley‐Liss, Inc.
Profiling and comparing transcription factors activated in non‐metastatic and metastatic nasopharyngeal carcinoma cells
Authors: Su Bo , Xiang Bo , Wang Li , Cao Li , Xiao Lan , Li Xiaoling , Li Xiayu , Wu Minghua , Li Guiyuan 
Published: November 2009

AbstractTranscription factors (TFs) are modulators of gene expression that are critically important in the establishment and progression of human cancers. In the current study, the activity profiles of TFs in a normal nasopharyngeal epithelial cell line and in nasopharyngeal carcinoma (NPC) cell lines were studied using oligonucleotide array‐based TF assays. Compared to the normal epithelial cell line NP69, nine TFs in the non‐metastatic NPC cell line (6‐10B) and eight TFs in a metastatic NPC cell line (5‐8F) were upregulated. Among upregulated TFs, Sp1, AP2, and ATF/CREB families exhibited relatively high activities in NPC cell lines. Transcription levels of Sp1, ATF‐1, ATF‐2, AP2α, AP2γ, and CREB1 were higher in 5‐8F cells than in 6‐10B cells. In addition, higher expression of the Sp1 target genes MMP‐9 and VEGF was observed in 5‐8F cells. Sp1 silencing reduced VEGF and MMP‐9 expression. Inhibition of Sp1 expression and activity in 5‐8F cells by mithramycin resulted in downregulated expression and secretion of MMP‐9 and VEGF, concomitant with inhibition of cell migration and invasion. These results suggest that dynamic changes in TF activities occur in NPC cells and that these changes may play important roles in regulating the expression of genes associated with the development and progression of NPC. J. Cell. Biochem. 109: 173–183, 2010. © 2009 Wiley‐Liss, Inc.
Suberoylanilide hydroxamic acid (SAHA) at subtoxic concentrations increases the adhesivity of human leukemic cells to fibronectin
Authors: Kuželová Kateřina , Pluskalová Michaela , Brodská Barbora , Otevřelová Petra , Elknerová Klára , Grebeňová Dana , Hrkal Zbyněk 
Published: November 2009

AbstractSuberoylanilide hydroxamic acid (SAHA) is an inhibitor of histone deacetylases (HDACs) which is being introduced into clinic for the treatment of hematological diseases. We studied the effect of this compound on six human hematopoietic cell lines (JURL‐MK1, K562, CML‐T1, Karpas‐299, HL‐60, and ML‐2) as well as on normal human lymphocytes and on leukemic primary cells. SAHA induced dose‐dependent and cell type‐dependent cell death which displayed apoptotic features (caspase‐3 activation and apoptotic DNA fragmentation) in most cell types including the normal lymphocytes. At subtoxic concentrations (0.5–1 µM), SAHA increased the cell adhesivity to fibronectin (FN) in all leukemia/lymphoma‐derived cell lines but not in normal lymphocytes. This increase was accompanied by an enhanced expression of integrin β1 and paxillin, an essential constituent of focal adhesion complexes, both at the protein and mRNA level. On the other hand, the inhibition of ROCK protein, an important regulator of cytoskeleton structure, had no consistent effect on SAHA‐induced increase in the cell adhesivity. The promotion of cell adhesivity to FN seems to be specific for SAHA as we observed no such effects with other HDAC inhibitors (trichostatin A and sodium butyrate). J. Cell. Biochem. 109: 184–195, 2010. © 2009 Wiley‐Liss, Inc.
Characterisation of the osteoclastogenic potential of human osteoblastic and fibroblastic conditioned media
Authors: Costa‐Rodrigues João , Teixeira Cristina A. , Sampaio Paula , Fernandes Maria H. 
Published: November 2009

AbstractAlthough M‐CSF and RANKL are sufficient to promote in vitro osteoclastogenesis, in vivo this is a complex process which requires the action of many signalling molecules and cellular crosstalks. In this work, isolated or combined conditioned media, obtained from human adult skin fibroblast and bone marrow cells, were tested for their osteoclastogenic potential, through an indirect co‐culture system, in the absence of recombinant M‐CSF and RANKL. Osteoclastogenesis was assessed on human peripheral blood mononuclear cells (PBMC) and CD14+ cell cultures by quantification of total protein content, tartrate‐resistant acid phosphatase (TRAP) activity, presence of multinucleated cells positive for TRAP, RT‐PCR of TRAP, CATK, CA2, c‐myc and c‐src and presence of multinucleated cells displaying actin rings, vitronectin and calcitonin receptors. Cultures supplemented with M‐CSF and RANKL were used as positive controls. It was observed that the conditioned medium from dexamethasone osteogenic‐induced bone marrow cell cultures displayed the highest osteoclastogenic potential, with similar behaviour to that observed in the presence of both M‐CSF and RANKL. Comparatively, fibroblastic conditioned medium elicited a slightly lower osteoclastogenic response. Combination of both conditioned media resulted in a significant increase of TRAP activity. On the other hand, conditioned medium from non‐osteogenic‐induced bone marrow cell cultures presented the lowest osteoclastogenic potential. These results were observed for both PBMC and CD14+ cell cultures, suggesting that fibroblast and osteoblast cells are able to modulate osteoclastogenesis in the absence of physical cell–cell interactions. In addition, osteoclastogenic potential of bone marrow cells increases with their osteoblastic differentiation. J. Cell. Biochem. 109: 205–216, 2010. © 2009 Wiley‐Liss, Inc.