bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dihydroartemisinin-driven selective anti-lung cancer proliferation by binding to EGFR and inhibition of NRAS signaling pathway-induced DNA damage
Authors: Li Liu-Gen , Peng Xing-Chun , Yang Zi-Yi , Han Ning , Gou Chang-Long , Shi Jun , Yu Li-Li , Chen Nan-Nan , Yu Ting-Ting , Li Tong-Fei , Li Xian-Yu , Hu Jun 
Published: May 2024

AbstractChemotherapeutic agents can inhibit the proliferation of malignant cells due to their cytotoxicity, which is limited by collateral damage. Dihydroartemisinin (DHA), has a selective anti-cancer effect, whose target and mechanism remain uncovered. The present work aims to examine the selective inhibitory effect of DHA as well as the mechanisms involved. The findings revealed that the Lewis cell line (LLC) and A549 cell line (A549) had an extremely rapid proliferation rate compared with the 16HBE cell line (16HBE). LLC and A549 showed an increased expression of NRAS compared with 16HBE. Interestingly, DHA was found to inhibit the proliferation and facilitate the apoptosis of LLC and A549 with significant anti-cancer efficacy and down-regulation of NRAS. Results from molecular docking and cellular thermal shift assay revealed that DHA could bind to epidermal growth factor receptor (EGFR) molecules, attenuating the EGF binding and thus driving the suppressive effect. LLC and A549 also exhibited obvious DNA damage in response to DHA. Further results demonstrated that over-expression of NRAS abated DHA-induced blockage of NRAS. Moreover, not only the DNA damage was impaired, but the proliferation of lung cancer cells was also revitalized while NRAS was over-expression. Taken together, DHA could induce selective anti-lung cancer efficacy through binding to EGFR and thereby abolishing the NRAS signaling pathway, thus leading to DNA damage, which provides a novel theoretical basis for phytomedicine molecular therapy of malignant tumors.
Contact lenses as novel tear fluid sampling vehicles for total RNA isolation, precipitation, and amplification
Authors: Boychev Nikolay , Lee Seokjoo , Yeung Vincent , Ross Amy E. , Kuang Liangju , Chen Lin , Dana Reza , Ciolino Joseph B. 
Published: May 2024

AbstractThe tear fluid is a readily accessible, potential source for biomarkers of disease and could be used to monitor the ocular response to contact lens (CL) wear or ophthalmic pathologies treated by therapeutic CLs. However, the tear fluid remains largely unexplored as a biomarker source for RNA-based molecular analyses. Using a rabbit model, this study sought to determine whether RNA could be collected from commercial CLs and whether the duration of CL wear would impact RNA recovery. The results were referenced to standardized strips of filtered paper (e.g., Shirmer Strips) placed in the inferior fornix. By performing total RNA isolation, precipitation, and amplification with commercial kits and RT-PCR methods, CLs were found to have no significant differences in RNA concentration and purity compared to Schirmer Strips. The study also identified genes that could be used to normalize RNA levels between tear samples. Of the potential control genes or housekeeping genes, GAPDH was the most stable. This study, which to our knowledge has never been done before, provides a methodology for the detection of RNA and gene expression changes from tear fluid that could be used to monitor or study eye diseases.
Exploring grandiose narcissism among surgeons: a comparative analysis
Authors: Moellmann Henriette L. , Rana Majeed , Daseking Monika , Petersohn Hendric , Rana Madiha 
Published: May 2024

AbstractThe concept of narcissism encompasses various personality traits, including cognitive, emotional and behavioural characteristics, which often lead to difficulties in maintaining a healthy self-esteem. This study examines the prevalence of narcissism traits (Admiration and Rivalry) in the surgical profession and their association with age, gender and professional experience. A total of 1390 participants (408 women, 982 men) took part in an online survey. The results show that female participants have significantly lower levels of rivalry than male colleagues. Additionally, age was found to be inversely correlated with both facets of narcissism, demonstrating that levels of narcissism decrease as age increases. Participants who are still in education tend to show higher levels of both facets. These results improve our understanding of personality traits in surgery and provide valuable insights for researchers and practitioners.
Static graph approximations of dynamic contact networks for epidemic forecasting
Authors: Shirzadkhani Razieh , Huang Shenyang , Leung Abby , Rabbany Reihaneh 
Published: May 2024

AbstractEpidemic modeling is essential in understanding the spread of infectious diseases like COVID-19 and devising effective intervention strategies to control them. Recently, network-based disease models have integrated traditional compartment-based modeling with real-world contact graphs and shown promising results. However, in an ongoing epidemic, future contact network patterns are not observed yet. To address this, we use aggregated static networks to approximate future contacts for disease modeling. The standard method in the literature concatenates all edges from a dynamic graph into one collapsed graph, called the full static graph. However, the full static graph often leads to severe overestimation of key epidemic characteristics. Therefore, we propose two novel static network approximation methods, DegMST and EdgeMST, designed to preserve the sparsity of real world contact network while remaining connected. DegMST and EdgeMST use the frequency of temporal edges and the node degrees respectively to preserve sparsity. Our analysis show that our models more closely resemble the network characteristics of the dynamic graph compared to the full static ones. Moreover, our analysis on seven real-world contact networks suggests EdgeMST yield more accurate estimations of disease dynamics for epidemic forecasting when compared to the standard full static method.
Application of a neural network model in estimation of frictional features of tribofilms derived from multiple lubricant additives
Authors: Noma Hiroshi , Aoki Saiko , Kobayashi Kenji 
Published: May 2024

AbstractIn the field of tribology, many studies now use machine learning (ML). However, ML models have not yet been used to evaluate the relationship between the friction coefficient and the elemental distribution of a tribofilm formed from multiple lubricant additives. This study proposed the possibility of using ML to evaluate that relationship. Friction tests revealed that, calcium tribofilms formed on the friction surface, with the friction coefficient increasing as a result of the addition of OBCS. Therefore, we investigated whether the convolutional neural network (CNN) model could recognize the tribofilms formed from OBCS and classify image data of the elemental distributions of these tribofilms into high and low friction-coefficient groups. The CNN model classifies only output values, and it’s difficult to see how the model has learned. Gradient-weighted class activation mapping (Grad-CAM) was performed using a CNN-based model, and this allowed the visualization of the areas important for classifying elemental distributions into friction coefficient groups. Furthermore, dimension reductions enabled the visualization of these distributions for classification into the groups. The results of this study suggested that the CNN model, the Grad-CAM, and the dimension reductions are useful for evaluating frictional features of tribofilms formed from multiple lubricant additives.
Northwestern Pacific Oceanic circulation shaped by ENSO
Authors: Wang You-Lin , Jin Fei-Fei , Wu Chau-Ron , Qiu Bo 
Published: May 2024

AbstractThe intricate currents of the Northwest Pacific Ocean, with strong manifestations along the westside rim, connect tropical and subtropical gyres and significantly influence East Asian and global climates. The El Niño/Southern Oscillation (ENSO) originates in the tropical Pacific Ocean and disrupts this ocean circulation system. However, the spatiotemporal dependence of the impact of ENSO events has yet to be elucidated because of the complexities of both ENSO events and circulation systems, as well as the increased availability of observational data. We thus combined altimeter and drifter observations to demonstrate the distinct tropical and subtropical influences of the circulation system on ENSO diversity. During El Niño years, the North Equatorial Current, North Equatorial Countercurrent, Mindanao Current, Indonesian Throughflow, and the subtropical Kuroshio Current and its Extension region exhibit strengthening, while the tropical Kuroshio Current weakens. The tropical impact is characterized by sea level changes in the warm pool, whereas the subtropical influence is driven by variations in the wind stress curl. The tropical and subtropical influences are amplified during the Centra Pacific El Niño years compared to the Eastern Pacific El Niño years. As the globe warms, these impacts are anticipated to intensify. Thus, strengthening observation systems and refining climate models are essential for understanding and projecting the enhancing influences of ENSO on the Northwest Pacific Oceanic circulation.
An empirical study on social network analysis for small residential communities in Gangwon State, South Korea
Authors: Jeong Dae-hyun , Lee Sang-Kyu , Ahn Moo-Eob , Kim Sang Mi , Ryu Ohk-Hyun , Park Kyung Suk , Shin Se Gye , Han Jae Hyun 
Published: May 2024

AbstractSocial Network Analysis (SNA) provides a dynamic framework for examining interactions and connections within networks, elucidating how these relationships impact behaviors and outcomes. This study targeted small residential communities in Gangwon State, South Korea, to explore network formation theories and derive strategies for enhancing health promotion services in rural communities. Conducted in 12 small residential areas, the survey led to a network categorization model distinguishing networks as formal, informal, or non-existent. Key findings demonstrated that demographic and socio-economic factors, specifically age, income, living environment, leisure activities, and education level, significantly influence network formation. Importantly, age, environmental conditions, satisfaction with public transportation, and walking frequency were closely associated with the evolution of formal networks. These results highlight the importance of early community network assessments, which must consider distinct network traits to develop effective health promotion models. Utilizing SNA early in the assessment process can improve understanding of network dynamics and optimize the effectiveness of health interventions.
Let there be Skyglow—light pollution from a large outdoor music festival (Lollapalooza Berlin 2016)
Authors: Jechow Andreas 
Published: May 2024

AbstractLive music is often linked to elaborate light shows, particularly at large outdoor music festivals. However, artificial light at night is one form of environmental pollution, light pollution, and because outdoor festivals emit a substantial amount of artificial light into the environment, they are a potential source of light pollution. So far, no studies that quantified the impact of such festivals on urban light pollution and skyglow exist. Here, the light pollution produced by a major rock festival (Lollapalooza Berlin 2016 with 70,000 visitors per day in an urban park) was investigated with ground-based radiometry and night-time light data. A small night-sky radiometer installed near the main stages and a calibrated digital camera from a nearby observation spot inside of the park were used to quantify changes in night sky brightness and direct light emissions within the park. The impact of the music festival on the urban skyglow was indeed measurable. Zenith luminance increased locally by up to a factor of 8 and illuminance increased by about 50% at the observation spot within the park. The radiance detected by night-time satellite was also increased during the festival. This is the first time, that light pollution from such a major rock music event was quantified.
One-year outcomes and safety assessment of faricimab in treatment-naïve patients with neovascular age-related macular degeneration in Japan
Authors: Mukai Ryo , Kataoka Keiko , Tanaka Koji , Miyara Yasunori , Maruko Ichiro , Nakayama Makiko , Watanabe Yuto , Yamamoto Akiko , Wakatsuki Yu , Onoe Hajime , Wakugawa Sorako , Terao Nobuhiro , Hasegawa Taiji , Kawai Moeko , Maruko Ruka , Itagaki Kanako , Honjo Jyunichiro , Okada Annabelle A. , Mori Ryusaburo , Koizumi Hideki , Iida Tomohiro , Sekiryu Tetsuju 
Published: May 2024

AbstractThis multicentre retrospective study evaluated the 1-year outcomes and safety profile of faricimab in treatment-naïve patients with neovascular age-related macular degeneration (nAMD). Fifty-five patients (57 eyes) underwent loading therapy comprising three monthly faricimab injections. If dryness was achieved by the third month, subsequent treat-and-extend (TAE) follow-up continued at a minimum 8-week interval thereafter. If wet macula persisted at the third month, a fourth dose was administered, followed by the TAE regimen. After 1 year, improvements in visual acuity (0.44 ± 0.46 [baseline] to 0.34 ± 0.48; p < 0.01) and central foveal thickness (326 ± 149 [baseline] to 195 ± 82 μm; p < 0.0001) were significant. Dry macula, characterised by the absence of intraretinal or subretinal fluid, was achieved in 65% of cases. Treatment intervals varied, ranging from 8 to 16 weeks, with 44% of eyes extending to a 16-week interval, followed by 33% at 8 weeks, 16% at 12 weeks, 5% at 14 weeks, and 2% at 10 weeks. Notably, 50% of the polypoidal choroidal vasculopathy patients exhibited complete regression of polypoidal lesions between 12 and 15 months. Faricimab treatment in nAMD patients induced significant improvements in central vision and retinal morphology. Two cases of retinal pigment epithelial tears and one case of iritis were reported as ocular complications.
Inhibitory mechanisms of docosahexaenoic acid on carbachol-, angiotensin II-, and bradykinin-induced contractions in guinea pig gastric fundus smooth muscle
Authors: Xu Keyue , Shimizu Miyuki , Yamashita Toma , Fujiwara Mako , Oikawa Shunya , Ou Guanghan , Takazakura Naho , Kusakabe Taichi , Takahashi Keisuke , Kato Keisuke , Yoshioka Kento , Obara Keisuke , Tanaka Yoshio 
Published: May 2024

AbstractWe studied the inhibitory actions of docosahexaenoic acid (DHA) on the contractions induced by carbachol (CCh), angiotensin II (Ang II), and bradykinin (BK) in guinea pig (GP) gastric fundus smooth muscle (GFSM), particularly focusing on the possible inhibition of store-operated Ca2+ channels (SOCCs). DHA significantly suppressed the contractions induced by CCh, Ang II, and BK; the inhibition of BK-induced contractions was the strongest. Although all contractions were greatly dependent on external Ca2+, more than 80% of BK-induced contractions remained even in the presence of verapamil, a voltage-dependent Ca2+ channel inhibitor. BK-induced contractions in the presence of verapamil were not suppressed by LOE-908 (a receptor-operated Ca2+ channel (ROCC) inhibitor) but were suppressed by SKF-96365 (an SOCC and ROCC inhibitor). BK-induced contractions in the presence of verapamil plus LOE-908 were strongly inhibited by DHA. Furthermore, DHA inhibited GFSM contractions induced by cyclopiazonic acid (CPA) in the presence of verapamil plus LOE-908 and inhibited the intracellular Ca2+ increase due to Ca2+ addition in CPA-treated 293T cells. These findings indicate that Ca2+ influx through SOCCs plays a crucial role in BK-induced contraction in GP GFSM and that this inhibition by DHA is a new mechanism by which this fatty acid inhibits GFSM contractions.
Development of an individualized model for predicting postoperative delirium in elderly patients with hepatocellular carcinoma
Authors: Yan Mingfang , Lin Zhaoyan , Zheng Huizhe , Lai Jinglan , Liu Yuming , Lin Zhenmeng 
Published: May 2024

AbstractPostoperative delirium (POD) is a common complication in older patients with hepatocellular carcinoma (HCC) that adversely impacts clinical outcomes. We aimed to evaluate the risk factors for POD and to construct a predictive nomogram. Data for a total of 1481 older patients (training set: n=1109; validation set: n=372) who received liver resection for HCC were retrospectively retrieved from two prospective databases. The receiver operating characteristic (ROC) curve, calibration plot, and decision curve analysis (DCA) were used to evaluate the performance. The rate of POD was 13.3% (148/1109) in the training set and 16.4% (61/372) in the validation set. Multivariate analysis of the training set revealed that factors including age, history of cerebrovascular disease, American Society of Anesthesiologists (ASA) classification, albumin level, and surgical approach had significant effects on POD. The area under the ROC curves (AUC) for the nomogram, incorporating the aforementioned predictors, was 0.798 (95% CI 0.752–0.843) and 0.808 (95% CI 0.754–0.861) for the training and validation sets, respectively. The calibration curves of both sets showed a degree of agreement between the nomogram and the actual probability. DCA demonstrated that the newly established nomogram was highly effective for clinical decision-making. We developed and validated a nomogram with high sensitivity to assist clinicians in estimating the individual risk of POD in older patients with HCC.
Mixture composition design of magnesium oxychloride cement-stabilized crushed stone materials applied as a pavement base
Authors: Zhang Huzhu , Luo Aolin , Sun Lijuan 
Published: May 2024

AbstractConventional binding materials, such as silicate cement and lime, present high energy consumption, pollution, and carbon emissions. Therefore, we utilize crushed stone as a stabilization material. Magnesium oxychloride cement (MOC) is modified and used as an inorganic admixture owing to its eco-friendly nature and low carbon content. We analysed the control indicators of an integrated design of MOC-stabilized crushed stone by conducting unconfined compressive strength and water-resistance tests. The optimum mixing composition of the MOC-stabilized crushed stone was determined through the response surface methodology. We determined the best approach and dosage for improving the water resistance of MOC-stabilized crushed stone by comparing the effects of four modification methods: fly ash, citric acid + silica fume, phosphoric acid + waterborne polyurethane, and dihydrogen phosphate potassium salt. We also perform a comparison with 5% ordinary silicate cement-stabilized crushed stone. The results indicate that the MOC-stabilized crushed stone exhibits a rapid increase in strength in the early stage, but this rate reduces after 28 days. The mixing design employs the 4-day unconfined compressive strength and 1-day water resistance coefficient as the technical indicators. The best mixing composition includes a 4.27% MOC dosage and a molar ratio of MgO/MgCl2 of 5.85. We use 1% citric acid + 10% silica fume in equal amounts to replace the MOC dopant method for composite modification of the MOC stabilized crushed stone. Consequently, the 1-day water resistance coefficient before water immersion is significantly increased from 0.78 to 0.91 and its 4-day unconfined compressive strength is only reduced by 0.10 MPa. This significantly improves the water resistance of the MOC-stabilized crushed stone and ensures that its strength remains unaffected, which is the optimal modification method. However, this method must ensure that a small amount of citric acid and silica fume are uniformly distributed in the MOC-stabilized crushed stone, which increases the construction difficulty of the road base.
Public perception of cultural ecosystem services in historic districts based on biterm topic model
Authors: Pan Ying , Nik Hashim Nik Hazwani , Goh Hong Ching 
Published: May 2024

AbstractHistoric districts are integral components of urban space, possessing diverse ecosystems that can offer various cultural services to the public. Urbanization and tourism development have led to the degradation of the ecological landscapes within historic districts, impacting sustainable development. Incorporating Cultural Ecosystem Services (CES) into the environmental research of historic districts can meet people's spiritual needs, enhance intangible benefits for humanity, and promote the conservation of the ecological environment within historic districts. Therefore, this study conducted perceptual quantification research on CES in four typical historic districts in Fuzhou City, crawling the online comment data through Python, mined its potential themes using Biterm Topic Model (BTM), and extracted and categorized the indicators of CES of historic districts by combining with expert consultation; meanwhile, the satisfaction of CES of historic districts is further explored with the help of two methods, namely, sentiment analysis and Importance-Performance analysis (IPA), and summarized the public perception of CES of historic districts. The results of the study show that: (1) the dimensions of public perception of CES in urban historic districts include Cultural Heritage, Leisure Tourism, Aesthetic Enjoyment, Spiritual Fulfillment, Inspiration, and Science Education six indicators, of which Leisure Tourism is most easily perceived by the public, but its satisfaction is not high; (2) the public's perception of positive emotions towards the CES of historic districts in Fuzhou is greater than negative emotions, with positive emotions accounting for 80.61%; (3) the public's overall satisfaction with the CES of Fuzhou's historic districts is high, and according to the final analysis results of the IPA, the four historic districts of Fuzhou are respectively proposed to improve the opinions. Based on big data, this study explores the public perception characteristics of CES in Fuzhou historic districts to promote its sustainable development and improve public well-being, which is of great significance to protecting the ecological environment of historic districts and improving the quality of cultural services.
Transient Myeloproliferative Disorder in a Neonate without Down Syndrome—A Rare Case Report and Review of the Literature
Authors: Menon Kizhakke Vellatt Devaki , Jayaraman Dhaarani , Amuthan Shwetha , Balakrishnan Umamaheswari , Koshy Teena , Subramanian Arun Kumar , Scott Julius Xavier 
Published: May 2024

AbstractTransient myeloproliferative disorder (TMD) is a self-limiting disorder characteristically seen in neonates with Down syndrome with or without somatic mosaicism. Trisomy-21 limited to the hematopoietic lineage alone has been described; awareness of which is very important for appropriate evaluation and counseling in phenotypically normal children.We report a newborn with TMD who presented at birth with intracranial bleed secondary to thrombocytopenia. Peripheral smear showed 10% blasts and flow cytometry further revealed myeloid blasts of megakaryocytic lineage. The child had no phenotypic features of Down syndrome.Cytogenetic analysis (fluorescence in situ hybridization) and the conventional karyotyping from peripheral blood showed trisomy-21 in blast cells and the findings completely cleared with peripheral clearance of blasts. The possibility of Down syndrome with mosaicism was considered, however, repeat conventional karyotyping from peripheral blood at D36 and D60 of life was normal, suggesting the gain of chromosome 21 was restricted to the TMD clones.The child was supported with irradiated platelet transfusions and adequate hydration. Spontaneous resolution with resolution of cytopenias and peripheral clearance of blasts were noted from D10 of life. The child is neurologically normal and growing well.Very few reports of TMD in newborn babies without Down syndrome have been described in the literature. Awareness about the diagnostic entity of TMD even without Down syndrome would help in appropriate management and counseling.