bluuebunny/crossref_metadata_2025_split huggingface dataset:
Tripartite Motif-Containing Protein 28 Is a Small Ubiquitin-Related Modifier E3 Ligase and Negative Regulator of IFN Regulatory Factor 7
Authors: Liang Qiming , Deng Hongying , Li Xiaojuan , Wu Xianfang , Tang Qiyi , Chang Tsung-Hsien , Peng Hongzhuang , Rauscher Frank J. , Ozato Keiko , Zhu Fanxiu 
Published: September 2011

Abstract
IFN regulatory factor 7 (IRF7) is a potent transcription factor of type I IFNs and IFN-stimulated genes and is known as the master regulator of type I IFN-dependent immune responses. Because excessive responses could harm the host, IRF7 itself is delicately regulated at the transcriptional, translational, and posttranslational levels. Modification of IRF7 by small ubiquitin-related modifiers (SUMOs) has been shown to regulate IFN expression and antiviral responses negatively, but the specific E3 ligase needed for IRF7 SUMOylation has remained unknown. As reported in this article, we have identified the tripartite motif-containing protein 28 (TRIM28) as a binding partner of IRF7. We have demonstrated that TRIM28 also interacts with the SUMO E2 enzyme and increases SUMOylation of IRF7 both in vivo and in vitro, suggesting it acts as a SUMO E3 ligase of IRF7. Unlike the common SUMO E3 ligase, protein inhibitor of activated STAT1, the E3 activity of TRIM28 is specific to IRF7, because it has little effect on IRF7’s close relative IRF3. TRIM28 is therefore, so far as we know, the first IRF7-specific SUMO E3 reported. TRIM28-mediated SUMOylation of IRF7 is increased during viral infection, and SUMOylation of transcription factors usually results in transcriptional repression. Overexpression of TRIM28 therefore inhibits IRF7 transactivation activity, whereas knockdown of TRIM28 has the opposite effect and potentiates IFN production and antiviral responses. Collectively, our results suggest that TRIM28 is a specific SUMO E3 ligase and negative regulator of IRF7.
Hemorrhagic Shock Activation of NLRP3 Inflammasome in Lung Endothelial Cells
Authors: Xiang Meng , Shi Xiaolian , Li Yuehua , Xu Jia , Yin Lianhua , Xiao Guozhi , Scott Melanie J. , Billiar Timothy R. , Wilson Mark A. , Fan Jie 
Published: September 2011

AbstractHemorrhagic shock (HS) due to major trauma and surgery predisposes the host to the development of systemic inflammatory response syndrome (SIRS), including acute lung injury (ALI), through activating and exaggerating the innate immune response. IL-1β is a crucial proinflammatory cytokine that contributes to the development of SIRS and ALI. Lung endothelial cells (EC) are one important source of IL-1β, and the production of active IL-1β is controlled by the inflammasome. In this study, we addressed the mechanism underlying HS activation of the inflammasome in lung EC. We show that high mobility group box 1 acting through TLR4, and a synergistic collaboration with TLR2 and receptor for advanced glycation end products signaling, mediates HS-induced activation of EC NAD(P)H oxidase. In turn, reactive oxygen species derived from NAD(P)H oxidase promote the association of thioredoxin-interacting protein with the nucleotide-binding oligomerization domain-like receptor protein NLRP3 and subsequently induce inflammasome activation and IL-1β secretion from the EC. We also show that neutrophil-derived reactive oxygen species play a role in enhancing EC NAD(P)H oxidase activation and therefore an amplified inflammasome activation in response to HS. The present study explores a novel mechanism underlying HS activation of EC inflammasome and thus presents a potential therapeutic target for SIRS and ALI induced after HS.
Case-matched series of enhanced versus standard recovery pathway in minimally invasive colorectal surgery
Authors: Lovely J K , Maxson P M , Jacob A K , Cima R R , Horlocker T T , Hebl J R , Harmsen W S , Huebner M , Larson D W 
Published: September 2011

Abstract

Background
Accelerated recovery pathways may reduce length of hospital stay after surgery but there are few data on minimally invasive colorectal operations.

Methods
An enhanced recovery pathway (ERP) was instituted, including preoperative analgesia, limited intravenous fluids and opiates, and early feeding. Intrathecal analgesia was administered as needed, but epidural analgesia was not used. The first 66 patients subjected to the ERP were case-matched by surgeon, procedure and age (within 5 years) with patients treated previously in a fast-track pathway (FTP). Short-term and postoperative outcomes to 30 days were compared.

Results
Hospital stay was shorter with the ERP than the FTP: median (interquartile range, i.q.r.) 3 (2–3) versus 3 (3–5) days (P &lt; 0·001). A 2-day hospital stay was achieved in 44 and 8 per cent of patients respectively (P &lt; 0·001). Patients in the ERP had a shorter time to recovery of bowel function: median (i.q.r.) 1 (1–2) versus 2 (2–3) days (P &lt; 0·001). Thirty-day complication rates were similar (32 per cent ERP, 27 per cent FTP; P = 0·570). Readmissions within 30 days were more common with ERP, but the difference was not statistically significant (10 versus 5 patients; P = 0·170). Total hospital stay for those readmitted was shorter in the ERP group (18 versus 23 days).

Conclusion
ERP decreased the length of hospital stay after minimally invasive colorectal surgery. Copyright © 2011 British Journal of Surgery Society Ltd. Published by John Wiley & Sons, Ltd.
Time‐Dependent Density Functional Theory for Calculating Origin‐Independent Optical Rotation and Rotatory Strength Tensors
Authors: Autschbach Jochen 
Published: September 2011

AbstractAn approach to calculate origin‐independent electronic chiroptical property tensors using time‐dependent density functional theory (TDDFT) and gauge‐including atomic orbital (GIAO) basis sets is evaluated. Computations of origin‐dependent optical rotation tensors and of rotatory strengths needed to simulate circular dichroism spectra are presented. The optical rotation tensor computations employ solutions of coupled perturbed Kohn–Sham equations for a dynamic electric field and a static magnetic field. Because the magnetic field is time independent, the GIAO treatment is somewhat simplified compared to a previously reported method, at some added computational cost if hybrid functionals are employed. GIAO rotatory strengths are also calculated, using transition density matrices from a standard TDDFT excitation energy module. A new implementation in the NWChem quantum chemistry package is employed for representative computations of origin‐invariant chiroptical response tensors for methyloxirane, norbornenone, and the ketosteroid androstadienone. For the steroid molecule the vibrational structure of the CD spectrum is modeled explicitly by using calculated Franck–Condon factors. The agreement with experiment is favorable.
Degradation‐induced changes of mechanical properties of an electro‐spun polyester‐urethane scaffold for soft tissue regeneration
Authors: Krynauw Hugo , Bruchmüller Lucie , Bezuidenhout Deon , Zilla Peter , Franz Thomas 
Published: September 2011

AbstractThe aim of this study was the in vitro investigation of the change in mechanical properties of a fast‐degrading electro‐spun polymeric scaffold for the use in soft tissue regenerative implants. Tubular scaffolds were electro‐spun from a DegraPol® D30 polyesther‐urethane solution (target outer diameter: 5.0 mm; scaffold wall thickness: 0.99 ± 0.18 mm). Scaffold samples were subjected to hydrolytic in vitro degradation for up to 34 days. The fiber network structure and fiber surfaces were inspected on scanning electron micrographs. Following vacuum drying and determination of mass, flat samples (9.69 ± 0.21 × 18.47 ± 2.62 mm, n = 5) underwent uni‐axial tensile testing (5 load cycles, strain ε = 0 to 20%; final extension to failure) in circumferential scaffold direction after 5, 10, 14, 18, 22, 26, 30, and 34 days of degradation. Scaffold mass did not change with degradation. Maximum elastic modulus, maximum stress and associated strain were Emax = 1.14 ± 0.23 MPa, σmax = 0.52 ± 0.12 MPa and εmax = 176.8 ± 21.9% before degradation and Emax = 0.43 ± 0.26 MPa, σmax = 0.033 ± 0.028 MPa and εmax = 24.6 ± 3.0% after 34 days of degradation. The deterioration of mechanical properties was not reflected in the ultrastructural surface morphology of the fibers. The current exploratory study provides a basis for the development of constitutive computational models of biodegradable scaffolds with future extension of the investigation most importantly to capture mechanical effects of regenerating tissue. Future studies will include degradation in biological fluids and assessment of molecular weight for an advanced understanding of the material changes during degradation. © 2011 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2011.
Testate amoebae as estuarine water‐level indicators: modern distribution and the development of a transfer function from a freshwater tidal marsh (Scheldt estuary, Belgium)
Authors: Ooms Marijke , Beyens Louis , Temmerman Stijn 
Published: September 2011

AbstractLittle is known about the century‐scale response of water levels in inland estuaries to sea‐level change and human modifications to estuarine morphology. This study explored the ability of using testate amoebae (Protozoa, Rhizopoda) from sediments of a freshwater tidal marsh as indicators of water level in an inland estuary. The hypothesis was that modern testate amoeba assemblages change with surface elevation (approximately the duration of tidal flooding) within a freshwater tidal marsh. Variation in testate amoeba assemblages in relation to multiple environmental variables and sediment characteristics was studied through redundancy analysis. This demonstrated that a significant part of the variation in modern testate amoeba assemblages could be explained by flooding frequency, surface elevation, organic content and particle size of the soil. Transfer functions, partial least squares and weighted average regressions were made to show that testate amoebae can be used for reconstruction of water level (with an accuracy of 0.05 Normalized Elevation). A preliminary test of application of the transfer function to palaeo testate amoeba assemblages showed promising results. Testate amoebae from a freshwater tidal marsh provide a potentially powerful new tool for estuarine water‐level reconstructions. Copyright © 2011 John Wiley & Sons, Ltd.
Geophysical surveys of the sediments of Loch Ness, Scotland: implications for the deglaciation of the Moray Firth Ice Stream, British–Irish Ice Sheet
Authors: Turner Andrew J. , Woodward John , Dunning Stuart A. , Shine Adrian J. , Stokes Chris R. , Cofaigh Colm Ó 
Published: September 2011

AbstractWe present results from three geophysical campaigns using high‐resolution sub‐bottom profiling to image sediments deposited in Loch Ness, Scotland. Sonar profiles show distinct packages of sediment, providing insight into the loch's deglacial history. A recessional moraine complex in the north of the loch indicates initial punctuated retreat. Subsequent retreat was rapid before stabilisation at Foyers Rise formed a large stillstand moraine. Here, the calving margin produced significant volumes of laminated sediments in a proglacial fjord‐like environment. Subsequent to this, ice retreated rapidly to the southern end of the loch, where it again deposited a sequence of proglacial laminated sediments. Sediment sequences were then disturbed by the deposition of a thick gravel layer and a large turbidite deposit as a result of a jökulhlaup from the Spean/Roy ice‐dammed lake. These sediments are overlain by a Holocene sheet drape. Data indicate: (i) a former tributary of the Moray Firth Ice Stream migrated back into Loch Ness as a major outlet glacier with a calving margin in a fjord‐like setting; (ii) there was significant sediment supply to the terminus of this outlet glacier in Loch Ness; and (iii) that jökulhlaups are important for sediment supply into proglacial fjord/lake environments and may compose >20% of proglacial sedimentary sequences. Copyright © 2011 John Wiley & Sons, Ltd.
Density‐dependence in the survival and reproduction of Bald Eagles: Linkages to Chum Salmon
Authors: Elliott Kyle Hamish , Elliott John E. , Wilson Laurie K. , Jones Iain , Stenerson Ken 
Published: September 2011

AbstractDuring the late 20th Century, due to decreases in both contamination and persecution, bald eagle (Haliaeetus leucocephalus) populations increased dramatically. Currently, mechanisms regulating eagle populations are not well understood. To examine potential regulating processes in the Pacific Northwest, where eagles are no longer primarily regulated by contaminants or direct persecution, we examined bald eagle reproductive success, breeding populations, winter populations, mortality, and salmon stream use. Wintering and breeding eagle populations in south‐coastal British Columbia (BC) quadrupled between the early 1980s and the late 1990s, and have since stabilized. Density‐dependent declines in reproduction occurred during 1986–2009, but not through changes in site quality. Mid‐winter survival was crucial as most mortality occurred then, and models showed that density‐dependent reductions in population growth rates were partially due to reduced survival. Wintering eagles in British Columbia fed heavily on chum salmon (Oncorhynchus keta) runs, and then switched to birds in late winter, when mortality was highest. Eagles tended to arrive after the peak in salmon availability at streams in BC as part of a migration associated with salmon streams from Alaska to northern Washington. Eagles were most abundant in southern BC during cold Alaskan winters and in years of high chum salmon availability. We suggest that eagle populations in the Pacific Northwest are currently partially limited by density on the breeding grounds and partially by adult mortality in late winter, likely due to reduced late winter salmon stocks forcing eagles to exploit more marginal prey supplies. Larger eagle populations have affected some local prey populations. © 2011 The Wildlife Society.
High selectivity dual‐wideband bandpass filter with triple‐mode stub‐loaded stepped‐impedance resonators
Authors: Deng Hong‐Wei , Liu Bing , Zhao Yong‐Jiu , Chen Wen , Zhang Xue‐Shun 
Published: September 2011

AbstractA novel high selectivity dual‐wideband microstrip bandpass filter (BPF) with two triple‐mode stub‐loaded stepped‐impedance resonators (SIRs) is proposed in this letter. Either of the SIRs can not only separately generate one passband but also control the passband performance. Because of the intrinsic characteristics of the SIRs, four transmission zeros can be generated to improve the selectivity. A dual‐wideband filter with the fractional bandwidth 15.4% and 10.2% is designed and fabricated. The dual‐wideband filter is evaluated by experiment and simulation with good agreement. © 2011 Wiley Periodicals, Inc. Microwave Opt Technol Lett 53:2851–2854, 2011; View this article online at wileyonlinelibrary.com. DOI 10.1002/mop.26371
Design of a broadband power amplifier using an optimized feedback network
Authors: Kim K. , Seo M. , Jeon J. , Kim M. , Kim H. , Lim H. , Park C. , Yang Y. 
Published: September 2011

AbstractThis article presents a systematic design method for ultra broadband power amplifiers using an optimized feedback network. Based on the analysis using the network parameters for the open‐loop circuit and feedback network, a design and optimization procedure was established. To make the gain response as flat as possible throughout the broad operating frequency band, the optimized component values of the feedback network were found using an optimization program which was built based on the least‐mean‐square‐error algorithm in MATLAB. Single‐ended broadband power amplifiers were implemented to verify the optimization results for various target gains, as well as source and load impedance sets. One of the single‐ended amplifiers was selected for use as part of the push–pull power amplifier which includes broad‐band 1:1 transmission line transformers. For the operational bandwidth from 8 to 800 MHz, the ultra broad‐band push–pull power amplifier exhibited a flat gain response of ±0.331 dB from 17.2 dB, a P1dB of more than 40.5 dBm, and high PAE from 26.7 to 45 % at each P1dB point. © 2011 Wiley Periodicals, Inc. Microwave Opt Technol Lett 53:2846–2851, 2011; View this article online at wileyonlinelibrary.com. DOI 10.1002/mop.26372
A novel microstrip band‐pass filter based on hole coupling structure
Authors: Yuan Yan , Xu Jun , Xu Yan‐Qing , Zhang Xiao‐Chuan 
Published: September 2011

AbstractA novel C‐band hole‐coupled bandpass filter with metallized post (or via‐hole) arrays directly embedded in middle of the microstrip line is presented in this letter.The proposed filter removes via‐hole arrays embedded along waveguide section from the half‐mode substrate integrated waveguide filter, while the new concept simplifies the structure of previous filter. Simulated and experimental results show that the proposed filter of this paper has good performances of low insertion loss, return loss, and better rejection characteristics. The insertion loss of measured four‐pole filter is about 0.8 dB, and the return loss is better than −25 dB in the whole passband. Keeping the advantages of excellent performances, the proposed filter can be constructed more conveniently and is suitable for low‐cost planar circuit. © 2011 Wiley Periodicals, Inc. Microwave Opt Technol Lett 53:2811–2814, 2011; View this article online at wileyonlinelibrary.com. DOI 10.1002/mop.26373
CMOS (2.28 mW, 67.28–80.78 GHz) divide‐by‐4 direct injection‐locked frequency divider using tunable LC source‐degeneration
Authors: Chen Chang‐Zhi , Wang Chien‐Chin , Lin Yo‐Sheng , Huang Guo‐Wei 
Published: September 2011

AbstractA 67.28–80.78 GHz CMOS divide‐by‐4 direct injection‐locked frequency divider (DILFD4) using tunable LC source‐degeneration (TLCSD) for operation frequency and locking range (LR) enhancement is demonstrated.The TLCSD is made by adding two tunable LC tanks, where varactors are used as the required capacitors, to the source terminals of the cross‐coupled transistor pair of the DILFD4. Compared with the traditional cross‐coupled transistor pair, the proposed one significantly decreases the equivalent parallel capacitance (CEQ). This in turn results in the increase of both the operation frequency and the LR of the DILFD4. The DILFD4 dissipated 2.28 mW from a 1.2 V power supply and achieved a total LR of 18.24% (i.e., 13.5 GHz, from 67.28 to 80.78 GHz). Furthermore, the DILFD4 achieved excellent output phase‐noise of −137.14 dBc/Hz at 1 MHz offset when the input signal was locked at 68.116 GHz. The chip area was 1.025 × 0.765 mm2 excluding the test pads. © 2011 Wiley Periodicals, Inc. Microwave Opt Technol Lett 53:2776–2781, 2011; View this article online at wileyonlinelibrary.com. DOI 10.1002/mop.26385
A transceiver with injection‐locked frequency multiplier for short‐range wireless applications
Authors: Chen Hsiao‐Chin , Kuo Chia‐Hao , Lee Wei‐Kan 
Published: September 2011

AbstractA transceiver with injection‐locked frequency multiplier is presented in 0.18‐μm CMOS technology for short‐range wireless medical applications. The injection‐locked technique is applied to a frequency multiplier to synthesize the low‐phase‐noise RF carrier of the transmitter, where a crystal oscillator is used as the signal source for injection and an 888‐MHz carrier is synthesized from the 55.5‐MHz crystal by the frequency multiplier. At 888 MHz, the injection‐locked frequency multiplier exhibits low phase noise of −116 dBc/Hz within offset frequency range from 100 kHz to 1 MHz. In addition, a receiver is implemented by adopting envelope detection architecture. The transmitter delivers an output power of −14 dBm at 22.2 mW and the receiver achieves a sensitivity of −58 dBm at 4.1 mW. With off‐chip antennas, a wireless link can be established by the transmitter and the receiver at a distance of 30 cm. © 2011 Wiley Periodicals, Inc. Microwave Opt Technol Lett 53:2733–2737, 2011; View this article online at wileyonlinelibrary.com. DOI 10.1002/mop.26387
Enhanced optical single sideband modulation based on fiber nonlinearity
Authors: Tsai W. S. , Lin Z.S. , Hsu C. H. 
Published: September 2011

AbstractWe propose an optical single sideband (OSSB) modulation scheme using stimulated Brillouin scattering (SBS) in fiber to achieve OSSB modulation. Drive with 10.87‐GHz radio frequency signal into Mach–Zehnder modulator (MZM). Because of the SBS effect, lower sideband of modulated signal is amplified and upper sideband is attenuated as well. By properly adjust the phase shifter for phase difference between the two paths of electrical signal. Output signal is OSSB format, after 25‐km SMF transmission, we can observe good system performances including sideband power ratio and phase noise using by an optical spectrum analyzer and an electrical spectrum analyzer. © 2011 Wiley Periodicals, Inc. Microwave Opt Technol Lett 53:2730–2733, 2011; View this article online at wileyonlinelibrary.com. DOI 10.1002/mop.26388
All‐electronic terahertz spectrometer for biosensing
Authors: Debus Christian , Spickermann Gunnar , Nagel Michael , Bolívar Peter Haring 
Published: September 2011

AbstractA compact and cost‐efficient all‐electronic terahertz (THz) system is presented for the spectroscopic read‐out of marker‐free THz biosensor chips. The table‐top system is based on only one oscillator for emitter and quasi‐heterodyne detector operation. Frequency mixing is applied to perform THz signal frequency sweeps from 220 to 320 GHz in less than 250 μs. The concept is explained and demonstrated at exemplary biochip measurements. Results and performance of the electronic system are compared with the laser‐based THz‐time‐domain spectroscopy. © 2011 Wiley Periodicals, Inc. Microwave Opt Technol Lett 53:2889–2902, 2011; View this article online at wileyonlinelibrary.com. DOI 10.1002/mop.26392
HF Antenna design optimization for railway spot signalling systems
Authors: Sancho Juan Ignacio , Mendizábal Jaizki , Gurutzeaga Iñaki , Villaro Almir , Adin Iñigo , Bistue Guillermo 
Published: September 2011

AbstractTransmitting antenna in a Railway Spot Signalling System needs to be optimized in order to ensure data transfer reliability and minimize the required power. This paper analyses the improvement of the HF transmitting antenna taking into account the size of the receiving antenna, the presence of metallic objects and the misalignment between transmitting and receiving antennas. A novel HF transmitting antenna structure is proposed and verified to improve the read range. © 2011 Wiley Periodicals, Inc. Microwave Opt Technol Lett 53:2742–2746, 2011; View this article online at wileyonlinelibrary.com. DOI 10.1002/mop.26400