bluuebunny/crossref_metadata_2025_split huggingface dataset:
Causal relationship between periodontal disease-related phenotype and knee osteoarthritis: A two-sample mendelian randomization analysis
Authors: Shen Longqiang , Niu Di , Deng Gang 
Published: May 2024

Objective
This study aimed to explore the bidirectional causal relationship between periodontal disease-related phenotype (PDRP) and knee osteoarthritis (KOA) in a European population using a two-sample Mendelian Randomization (MR) approach.

Methods
We leveraged publicly available GWAS summary statistics for PDRP (n = 975) and KOA (n = 403,124), assessing their roles as both exposures and outcomes. Our comprehensive MR analysis employed various methods, including inverse variance weighting (IVW), weighted median, Egger regression, simple mode, and weighted mode, to enhance the robustness of our findings. To ensure the reliability of our instrumental variables, we implemented a rigorous screening process based on p-values and F-values, utilized Phenoscanner to investigate potential confounders, and conducted sensitivity analyses.

Results
Our analysis identified five SNPs associated with PDRP and three SNPs with KOA, all surpassing the genome-wide significance threshold, as instrumental variables. The IVW method demonstrated a significant causal relationship from PDRP to KOA (beta = 0.013, SE = 0.007, P = 0.035), without evidence of directional pleiotropy (MR-Egger regression intercept = 0.021, P = 0.706). No support was found for reverse causality from KOA to PDRP, as further MR analyses yielded non-significant P-values. Additionally, funnel plots and Cochran’s Q test detected no significant heterogeneity or directional pleiotropy, confirming the robustness of our results. In multivariate analysis, when considering smoking, alcohol consumption, BMI collectively no direct causal relationship between KOA and PDRP. Conversely, smoking and higher BMI were independently associated with an increased risk of KOA.

Conclusion
In conclusion, our analysis revealed no direct causal relationship from KOA to PDRP. However, a causal relationship from PDRP to KOA was observed. Notably, when adjusting for potential confounders like smoking, alcohol intake, and BMI, both the causal connection from PDRP to KOA and the inverse relationship were not substantiated.
Machine learning prediction of nutritional status among pregnant women in Bangladesh: Evidence from Bangladesh demographic and health survey 2017–18
Authors: Begum Najma , Rahman Mohd. Muzibur , Omar Faruk Mohammad 
Published: May 2024

Aim
Malnutrition in pregnant women significantly affects both mother and child health. This research aims to identify the best machine learning (ML) techniques for predicting the nutritional status of pregnant women in Bangladesh and detect the most essential features based on the best-performed algorithm.

Methods
This study used retrospective cross-sectional data from the Bangladeshi Demographic and Health Survey 2017–18. Different feature transformations and machine learning classifiers were applied to find the best transformation and classification model.

Results
This investigation found that robust scaling outperformed all feature transformation methods. The result shows that the Random Forest algorithm with robust scaling outperforms all other machine learning algorithms with 74.75% accuracy, 57.91% kappa statistics, 73.36% precision, 73.08% recall, and 73.09% f1 score. In addition, the Random Forest algorithm had the highest precision (76.76%) and f1 score (71.71%) for predicting the underweight class, as well as an expected precision of 82.01% and f1 score of 83.78% for the overweight/obese class when compared to other algorithms with a robust scaling method. The respondent’s age, wealth index, region, husband’s education level, husband’s age, and occupation were crucial features for predicting the nutritional status of pregnant women in Bangladesh.

Conclusion
The proposed classifier could help predict the expected outcome and reduce the burden of malnutrition among pregnant women in Bangladesh.
Oasis: An Optimal Disjoint Segmented Learned Range Filter
Authors: Chen Guanduo , He Zhenying , Li Meng , Luo Siqiang 
Published: May 2024

The learning-enhanced data structure has inspired the development of the range filter, bringing significantly better false positive rate (FPR) than traditional non-learned range filters. Its core idea is to employ piece-wise linear functions that uniformly map the entire key space into a bitmap sequentially. Nonetheless, such uniform mapping can be space-ineffective, impacting FPRs.
This paper introduces Oasis, a novel learned range filter that divides the key space into disjointed intervals by excluding large empty ranges explicitly and optimally maps those unpruned intervals into a compressed bitmap. The configuration optimality in Oasis is guaranteed by a careful theoretical analysis. To enhance the versatility of Oasis, we further propose Oasis+, which integrates the design space of both learned and non-learned filters, delivering robust performance across a wide range of workloads. We evaluate the performance of both Oasis and Oasis+ when integrated into the key-value system RocksDB, using a diverse set of real-world and synthetic datasets and workloads. In RocksDB, Oasis and Oasis+ improve the performance by up to 1.4× and 6.2× when compared to state-of-the-art learned and non-learned range filters.
New Apostolic Reformation und Bund Freikirchlicher Pfingstgemeinden
Authors: Spornhauer Dirk 
Published: May 2024

Zusammenfassung
Die New Apostolic Reformation (NAR) spielt in der weltweiten Pfingstbewegung seit dem Beginn des 21. Jahrhunderts eine immer größere Rolle. Sie betont hierarchische Organisationsformen. Der vorliegende Artikel untersucht aktuelle Auswirkungen dieser Bewegung auf die kongregationalistisch organisierte deutsche Pfingstorganisation „Bund Freikirchlicher Pfingstgemeinden“ (BFP). Dazu wird die Position des BFP in diesem Punkt mit der der Mutterkirche „Assemblies of God“ (AoG) verglichen. Zusätzlich werden exemplarisch die Einflüsse der NAR-Theologie auf drei BFP-Gemeinderegionen dargestellt. Zu Beginn werden einzelne Überzeugungen der NAR skizziert.
The Model of the Higher Church Administration of the Russian Church as of the Local Council 1917–1918 Decisions
Authors: Mramornov Alexander I. 
Published: May 2024

Abstract
The author of this article reviews the reforms of the higher administration of the Russian Church that were carried out by the All-Russian Local Council in 1917–1918. These reforms decisively changed the system of government of one of the largest Orthodox Churches in the world. The model included the regular holding of Local Councils of various types, the leadership of the Church by the Patriarch, the work of permanent bodies of church power – the Synod and the Supreme Church Council (with the participation of not only bishops but also clergy and laity), the creation of church districts on the territory of the former Russian Empire. New managing mechanisms began their work, but after a few years they were curtailed due to repressions against Russian Orthodoxy, but at the end of the twentieth and beginning of the twenty-first centuries they were not resumed for other, even though also political, reasons.
Zur Frage demokratischer Leitung und Mitbestimmung in apostolischen Gemeinschaften
Authors: Eberle Mathias 
Published: May 2024

Zusammenfassung
Wie denken apostolische Christen über Leitung? Woher kommen ihre Haltungen und wie sieht es mit demokratischer Mitbestimmung in der Neuapostolischen Kirche, den Katholisch-apostolischen Gemeinden und weiteren apostolischen Gemeinschaften heute aus? Der Artikel erläutert die Verortung der Apostolischen im politischen Kontext des frühen 19. Jahrhunderts als im Selbstverständnis geistliche Gegenbewegung zu Demokratisierungsbestrebungen der Zeit und beleuchtet daraus folgende gegenwärtige Herausforderungen.
Der pseudoaugustinische

Sermo 167: Beobachtungen und Überlegungen zu Ursprung und Überlieferung mitsamt einer Edition seiner vermuteten Vorlage
Authors: Scheerer Christoph 
Published: May 2024

Abstract
The pseudo-augustinian Sermo 167 (PL 39:2069–2070) is a text of two pieces containing a short Easter homily and a list of benedictions of the Sunday. The oldest known but reworked exemplar is part of a larger homily in the manuscript Cambridge, Pembroke College Ms. 25 (s. 11). Though, in the manuscript Würzburg, Universitätsbibliothek M.p.th.q.28b (s. 8/9) the main parts of Sermo 167,1 and the list of benedictions as separate pieces were detected (fol. 22r–24v), similarly at the end of another larger homily; it was substantiated that Sermo 167,1 is a derivative cento of the larger Würzburg-homily which has been combined with the originally independent list of benedictions; a anglo-saxon context was proposed; the text of the whole Würzburg-homily and the list in the version of this manuscript has been emended and established; quotations and allusions were identified and indicated; a translation was added. Thus, this sermo of the manuscript Würzburg, Universitätsbibliothek M.p.th.q.28b as the predecessor of pseudo-augustinian Sermo 167 gives insights into the process of working and reworking of homilies in the carolingian and pre-carolingian aera.
Comparison of blood loss in total knee replacement surgery with and without tranexamic acid: a prospective, time framed and observational analytical study
Authors: Mandal Shaival , Chatterjee B. D. , Kar Abheek , Agarwal Saumya 
Published: May 2024

Background: Total knee replacement is one of the common orthopaedic procedures performed worldwide. Blood transfusion is one of the major requirements in TKR procedure due to the amount of blood loss during and after the procedure. We carried out a prospective study to determine the efficacy of tranexamic acid in controlling blood loss during TKR procedure.
Methods: Study was conducted at a tertiary care centre, involving cases operated by a single surgeon. Study included 140 patients undergoing primary TKR for advance degenerative disease of knee and were divided into two groups of 70 each, one group that received tranexamic acid before surgery and another group that did not receive tranexamic acid before surgery. Patient with allergy to the drug, hepato/renal dysfunction, DVT, abnormal PT and INR were not included. Tranexamic acid was given intravenously as well as intra-articular.
Results: Pre-operative haemoglobin ranged from 10.2 gm% to 14.4 gm% in the group getting tranexamic acid and from 10% to 14 % in the group not getting tranexamic acid. Post operatively haemoglobin varied from 8.4 gm% to 12.8 gm% in Group 1 and from 7.8 gm% to 12 gm% in Group 2. Difference of mean post-operative Hb (p=0.0045) and PCV (p=0.0024) in two groups was statistically significant.
Conclusions: We concluded that administration of tranexamic acid reduces the blood loss as well as need of blood transfusion in a patient undergoing total knee replacement.
Expérience de prise en charge de Xeroderma Pigmentosum au service de Dermatologie-vénérologie à Cotonou
Authors: Guérendo Peggy Mboli-Goumba , Diané Boh Fanta , Mekoun Nadège Agbessi , Koudoukpo Christiane , Akpadja Fabrice , Dégboé Bérénice 
Published: May 2024

Introduction: Le Xeroderma pigmentosum (XP) est une maladie génétique, entraînant une sensibilité accrue au rayonnement ultraviolet avec pour conséquences des lésions cutanées spécifiques sur les zones photoexposées. Observation clinique: Il s’agissait d’un garçon de 3 ans, sans antécédent familial particulier, reçu pour des troubles pigmentaires du visage, évoluant depuis un an, avec un début en période néonatale marqué par l’apparition de lésions bulleuses cutanées sur les zones photoexposées. Aucun facteur déclenchant n’était identifié. L’évolution de la maladie était marquée par l’apparition de macules bigarrées. Les signes accompagnateurs étaient une photophobie et un larmoiement. Les lésions cutanées évoluaient par périodes de poussées et rémissions dans un contexte de retard psychomoteur. Le XP était évoqué sur la base d’arguments cliniques. Aucun examen paraclinique spécifique n’était réalisé. Une protection solaire et un émollient étaient prescrits. La surveillance était ophtalmologique et neurologique. Conclusion : Le XP était évoqué uniquement sur la base d’arguments cliniques. Un bilan paraclinique aurait permis la confirmation du diagnostic. Devant les risques de complications, une prise en charge multidisciplinaire est nécessaire.

Introduction : Xeroderma pigmentosum (XP) is a genetic disorder, that leads to increased sensitivity to ultraviolet radiation with consequences such as specific skin lesions on areas of photoexposure. Case report : It was about a 3-year-old boy, with no particular family history, received for skin discolorations of the face, evolving since one year, with a beginning during a neonatal period marked with the occurrence of bullous skin lesions on photoexposed areas. No triggering factor was identified. The course of the disease was marked by the appearance of discolored macules. Accompanying signs were photophobia and tearing. The skin lesions were evolving through outbreaks and remission periods in the context of psychomotor retardation. XP was discussed based on clinical arguments. No specific paraclinic assessment was performed. Sun protection and a skin emollient were prescribed. Monitoring was ophthalmologic and neurological. Conclusion : XP was discussed based solely on clinical findings. Paraclinic assessment would have allowed the confirmation of the diagnosis. With the risks of complications, multidisciplinary management is necessary.
Using the TSS-RESTREND Methodology to Diagnose Post-Reclamation Vegetation Trends on the Western Slope of Colorado
Authors: Di Stéfano Sean , Karl Jason W. , Duniway Michael C. 
Published: May 2024

Reclamation Highlights:
A gradual positive increase in plant community response to precipitation occurred over time, indicating long-term recovery of plant communities in response to reclamation efforts. There was a diminishing effect of aridity on reclamation outcomes over time, suggesting that water availability has a reduced impact on long-term reclamation success. Variations were discovered in reclamation success among different management actions, highlighting the need for coordinated strategies and enhanced operator communication to maximize the effectiveness of reclamation.
Prevalence and risk factors of SARS-CoV-2 antibody responses and asymptomatic carriers among a cohort of 2,455 healthcare workers of a general hospital during the Covid-19 Pandemic
Authors: Barrufet Pilar , Serra-Prat Mateu , Palomera Elisabet , Ruiz Alicia , Tapias Gemma , Montserrat Noemí , Valladares Nicolau , Ruz Fran , Bolívar-Prados Mireia , Clavé Pere 
Published: May 2024

Abstract

Observational and prospective study to establish an immunological map of SARS-CoV-2 exposure of 2,455 healthcare workers (HCW) at the Maresme Health Consortium (CSdM), Catalonia, during COVID-19 pandemic, with serum sampling for antibody determination. In pre-vaccination serum samples, we performed an initial chemiluminescence immunoassay (CLIA) to detect: IgG+IgM+IgA and, in those with positive results, a differential analysis of IgM+IgA vs IgG by ELISA to detect an acute or past infection. A PCR was performed in nasopharyngeal swabs in positive IgM+IgA to confirm the non-diagnosed carriers of the virus. In post-vaccination samples, we assessed IgG SARS-CoV2 SPIKE-TRIMERIC and total antibodies to the nucleocapsid (N) protein of SARS-CoV-2. The individual occupational, social and health risk factors were assessed by a self-administrated epidemiological survey at each serum sampling period. Relatively large sample size, high participation rate in all phases of the study with four blood samples over time, high vaccination acceptance, and follow-up of the study cohort for 17 months (6-7 months before and 10-11 months after vaccination), represent important strengths of the study. As this is a study with an open cohort (with entrances and exits), it has made it possible to obtain an accurate picture of the epidemiological characteristics of the pandemic among CSdM HCW in real life. However, this open cohort design has made it difficult to assess risk factors that, on the other hand, have shown some changes over time due to progressive implementation of protective and preventive measures. Moreover, this is not a clinical trial but an observational study, so it is not the best design to assess the efficacy of a vaccine. However, it allows us to assess its effectiveness in terms of immunological response in real conditions.
Amplification and sequencing of HBV pol gene
Authors: Marcelino Rute 
Published: May 2024

Abstract

This is a homemade protocol designed to amplify and sequence a 943bp fragment of the HBV pol gene. The polymerase region amplified here can be used to analyze drug resistance mutations. We use this protocol with HBV nucleic acid extracted from 200 µl of plasma sample, using the QIAamp DNA Blood Mini Kit (Qiagen, USA) following the manufacturer's procedure.
A Global Systematic Review, Meta-analysis and Health Risk Assessment of the Concentration of Polycyclic Aromatic Hydrocarbons (PAHs) in Bread: A Protocol for a Systematic Review with Meta-analysis
Authors: Touranlou Fateme Asadi , Sani seyedeh Belin Tavakkoli , Ghavami Vahid , Hashemi Mohammad 
Published: May 2024

Abstract

Background: Polycyclic aromatic hydrocarbons are formed during various industrial processes and activities, mainly through pyrolysis, especially when organic matter is incompletely combusted. There is evidence that PAHs affect host resistance, humoral immunity, and immune system development. These health problems may occasionally be linked to genotoxicity, chronic intoxication symptoms, and carcinogenic, mutagenic, and teratogenic effects. One of the most common food sources in human nutrition is bread . Bread can be contaminated with PAHs due to contamination of baking ingredients (mainly flour) and the baking process. So, this study describes a systematic review protocol with meta-analysis on the concentration of PAHs in bread on a global scale.
Methods: Literature searches will be conducted in Science Direct, PubMed, web of Science, Scopus, and Google Scholar will be searched from early to September 2022. Each database will be searched independently, and the reference lists of all studies will be manually searched for relevant literature, which may be omitted during the search. We will use keywords related to the terms “polycyclic aromatic hydrocarbons” and “PAHs”. These keywords are then combined with the terms “bread” and “health risk” to be used.
Discussion: A systematic review with meta-analysis to assess the health risks associated with PAH levels in bread will be conducted. This study will be investigated all bread consumed on a global scale. In order to be able to compare the amount of PAHs in bread, the type of bread, the type of oven, and the geographical origin will be used to determine which Factor is most effective in raising PAHs concentration.
In situ neutral detergent fibre digestibility, in vitro organic matter digestibility and methane production of four Namibian rangeland encroacher bush species used as fodder
Authors: Shiningavamwe Katrina Lugambo , Mupangwa Johnfisher , Lutaaya Emmanuel , Halmemies-Beauchet-Filleau Anni , Vanhatalo Aila 
Published: May 2024

Abstract

Encroacher bush species have been undervalued due to insufficient information about their potential feeding value. This study evaluated the in situ neutral detergent fibre (NDF) digestibility, in vitro organic matter digestibility (OMD) and methane production of Senegalia mellifera, Dichrostachys cinerea, Terminalia sericea and Rhigozum trichotomum. Leaves and twigs (≤ 20 mm) were harvested during late dry and early rainy seasons. The indigestible neutral detergent fibre (iNDF) and digestible neutral detergent fibre (dNDF) were determined by the in sacco nylon bag technique. The in vitro organic matter digestibility (OMD) of bush samples were based on the two-stage pepsin + cellulase solubility technique. Methane gas production was determined by in vitro method using the Gas Endeavour Automatic Gas Flow Measuring System. The iNDF for D. cinerea and S. mellifera decreased (P < 0.0001) from late dry to early rainy season, while that of R. trichotomum and T. sericea increased. Digestible NDF decreased (P < 0.001) from late dry to early rainy season for all species, except S. mellifera. Species and species x season interaction affected (P < 0.0001) OMD. Except for S. mellifera, the in vitro OMD decreased (P < 0.001) from late dry to early rainy season. In vitro methane gas production of all species was higher (P = 0.0004) during the late dry season compared to the early rainy season (147.6 versus 92.0 mL/g DM). In conclusion, based on the low OMD and high iNDF, the studied species may require further intervention to improve their digestibility and feeding value.
Imatinib mesylate reduces c-Myc translocation in double-hit lymphoma cells by suppressing inducible cytidine deaminase
Authors: Zhang JingCheng , Zhou Sheng , Jiang SiSi , He Fang , Tu Yan , Hu HuiXian 
Published: May 2024

Abstract

Double-hit lymphoma (DHL) with c-Myc gene translocation is highly aggressive and has a poor prognosis. In DHL cells, activation-induced cytidine deaminase (AID) promotes antibody class switch recombination (CSR), ultimately leading to c-Myc gene translocation caused by Myc/IgH DNA double-strand breaks. In this study, imatinib mesylate downregulated the AID and c-Myc proteins in patients with chronic myelogenous leukemia associated with DHL. In addition, imatinib mesylate reduced AID expression and c-Myc gene translocation in SU-DHL-4 and OCI-Ly18 DHL cells with c-Myc gene translocation. Imatinib mesylate exerted significant inhibitory effects on the proliferation and metastasis of SU-DHL-4 and OCI-Ly18 cells. Finally, imatinib mesylate reduced not only tumor burden in DHL mouse models, but also AID expression and c-Myc gene translocation in vivo. These findings reveal that imatinib mesylate effectively reduces the carcinogenic function of c-Myc in DHL, providing novel strategies for developing therapies targeting c-Myc-driven DHL.