bluuebunny/crossref_metadata_2025_split huggingface dataset:
Why Human Rights Fail to Protect Undocumented Migrants
Authors: Noll Gregor 
Published: April 2010

AbstractIn this article, I depart from the factual difficulties of undocumented migrants to access a state’s protection mechanisms for avowedly universal human rights. I relate this aporia to two competing conceptions of territorial jurisdictions. Drawing on the Convention on the Rights of the Child and the Migrant Workers Convention, I separate the sphere of the political community (the polis) and that of the house-hold (the oikos) in developing a political theory of undocumented migration. It rests two central tenets: one is a tributary transaction between sending state and host state, in the course of which the undocumented migrant worker is offered without conditions attaching, yet with the hope of remittances flowing in return. This offering relates to the oikos, which makes available a limited degree of protection under labour law. The second is a contractual form of submission by the undocumented migrant worker, which is structurally analogous to the master-slave relationship developed in Hobbes’ defense of war slavery. This is related to the polis, which denies all meaningful political activity to the undocumented migrant (as reflected in the denied right to found labour unions). Finally, drawing on Werner Hamacher’s work, I analyse how human rights are intrinsically related to a position of privacy, which escalates into a form of isolation under the structures producing undocumented migrants.
Tracking and Mean Structure of Easterly Waves over the Intra-Americas Sea
Authors: Serra Yolande L. , Kiladis George N. , Hodges Kevin I. 
Published: April 2010

Abstract
Easterly waves (EWs) are prominent features of the intertropical convergence zone (ITCZ), found in both the Atlantic and Pacific during the Northern Hemisphere summer and fall, where they commonly serve as precursors to hurricanes over both basins. A large proportion of Atlantic EWs are known to form over Africa, but the origin of EWs over the Caribbean and east Pacific in particular has not been established in detail. In this study reanalyses are used to examine the coherence of the large-scale wave signatures and to obtain track statistics and energy conversion terms for EWs across this region. Regression analysis demonstrates that some EW kinematic structures readily propagate between the Atlantic and east Pacific, with the highest correlations observed across Costa Rica and Panama. Track statistics are consistent with this analysis and suggest that some individual waves are maintained as they pass from the Atlantic into the east Pacific, whereas others are generated locally in the Caribbean and east Pacific. Vortex anomalies associated with the waves are observed on the leeward side of the Sierra Madre, propagating northwestward along the coast, consistent with previous modeling studies of the interactions between zonal flow and EWs with model topography similar to the Sierra Madre. An energetics analysis additionally indicates that the Caribbean low-level jet and its extension into the east Pacific—known as the Papagayo jet—are a source of energy for EWs in the region. Two case studies support these statistics, as well as demonstrate the modulation of EW track and storm development location by the MJO.
Separating the Dynamical Effects of Climate Change and Ozone Depletion. Part I: Southern Hemisphere Stratosphere
Authors: McLandress Charles , Jonsson Andreas I. , Plummer David A. , Reader M. Catherine , Scinocca John F. , Shepherd Theodore G. 
Published: April 2010

Abstract
A version of the Canadian Middle Atmosphere Model that is coupled to an ocean is used to investigate the separate effects of climate change and ozone depletion on the dynamics of the Southern Hemisphere (SH) stratosphere. This is achieved by performing three sets of simulations extending from 1960 to 2099: 1) greenhouse gases (GHGs) fixed at 1960 levels and ozone depleting substances (ODSs) varying in time, 2) ODSs fixed at 1960 levels and GHGs varying in time, and 3) both GHGs and ODSs varying in time. The response of various dynamical quantities to the GHG and ODS forcings is shown to be additive; that is, trends computed from the sum of the first two simulations are equal to trends from the third. Additivity is shown to hold for the zonal mean zonal wind and temperature, the mass flux into and out of the stratosphere, and the latitudinally averaged wave drag in SH spring and summer, as well as for final warming dates. Ozone depletion and recovery causes seasonal changes in lower-stratosphere mass flux, with reduced polar downwelling in the past followed by increased downwelling in the future in SH spring, and the reverse in SH summer. These seasonal changes are attributed to changes in wave drag caused by ozone-induced changes in the zonal mean zonal winds. Climate change, on the other hand, causes a steady decrease in wave drag during SH spring, which delays the breakdown of the vortex, resulting in increased wave drag in summer.
Role of Parameterized Eddies in the Energy Budget of the Global Thermohaline Circulation: Cabbeling versus Restratification
Authors: Urakawa L. Shogo , Hasumi Hiroyasu 
Published: April 2010

Abstract
The gravitational potential energy (GPE) budget of the global thermohaline circulation is investigated with a non-eddy-resolving model under a realistic configuration. The model incorporates parameterizations for mesoscale eddies and an equation of state that takes pressure dependency of density into account. Both vertical mixing and energy conversion from kinetic energy equally supply the GPE to the ocean, and its total amount is about 680 GW. Earlier studies point out that most of the GPE supplied by vertical mixing and energy conversion from kinetic energy is consumed by the cabbeling effect associated with the diabatic diffusion process. However, this study reveals that over 60% of the supplied GPE is adiabatically converted to eddy kinetic energy by the layer thickness diffusion and undergoes viscous dissipation, which is not resolved in the low-resolution model used here. Although the cabbeling effect on the GPE budget reduces in the presence of parameterizations of mesoscale eddies, its contribution is not necessarily negligible.
A New Parameterization for Entrainment in Overflows
Authors: Cenedese Claudia , Adduce Claudia 
Published: April 2010

Abstract
Dense overflows entrain surrounding waters at specific locations, for example, sills and constrictions, but also along the descent over the continental slope. The amount of entrainment dictates the final properties of these overflows, and thus is of fundamental importance to the understanding of the formation of deep water masses. Even when resolving the overflows, coarse resolution global circulation and climate models cannot resolve the entrainment processes that are often parameterized. A new empirical parameterization is suggested, obtained using an oceanic and laboratory dataset, which includes two novel aspects. First, the parameterization depends on both the Froude number (Fr) and Reynolds number of the flow. Second, it takes into account subcritical (Fr &lt; 1) entrainment. A weak, but nonzero, entrainment can change the final density and, consequently, the depth and location of important water masses in the open ocean. This is especially true when the dense current follows a long path over the slope in a subcritical regime, as observed in the southern Greenland Deep Western Boundary Current. A streamtube model employing this new parameterization gives results that are more consistent with previous laboratory and oceanographic observations than when a classical parameterization is used. Finally, the new parameterization predictions compare favorably to recent oceanographic measurements of entrainment and turbulent diapycnal mixing rates, using scaling arguments to relate the entrainment ratio to diapycnal diffusivities.
On the methodology of drug trials in migraine with aura
Authors: Hauge Anne Werner , Hougaard Anders , Olesen Jes 
Published: April 2010

Introduction: Specific problems occur in clinical treatment trials for migraine with aura that differ from those encountered in treatment trials for migraine without aura. Discussion: Based on our experience with four such trials, we point to a number of possible solutions and outline areas for future inquiry. We make recommendations about subject selection; the choice, definition and assessment of outcome measures; optimal treatments in relation to aura and headache; and we provide samples of study report forms used to record occurrence of aura and headache in this population.
Biomechanical Comparisons of Knee Stability After Anterior Cruciate Ligament Reconstruction Between 2 Clinically Available Transtibial Procedures
Authors: Kondo Eiji , Merican Azhar M. , Yasuda Kazunori , Amis Andrew A. 
Published: April 2010

Background: Several trials have compared the clinical results between anatomic double-bundle and single-bundle anterior cruciate ligament reconstruction procedures. However, it remains controversial whether the anatomic double-bundle procedure is superior to the single-bundle procedure. Hypothesis: The anatomic double-bundle procedure will be better than the single-bundle procedure at resisting anterior laxity, internal rotation laxity, and pivot-shift instability. Study Design: Controlled laboratory study. Methods: Eight cadaveric knees were tested in a 6 degrees of freedom rig using the following loading conditions: 90-N anterior tibialforce, 5-N·m internal and external tibial torques, and a simulated pivot-shift test. Tibiofemoral kinematics during the flexion-extension cycle were recorded with an optical tracking system for (1) intact, (2) anterior cruciate ligament–deficient knee, (3) anatomic double-bundle reconstruction, and (4) single-bundle reconstruction placed at 11 o’clock in the intercondylar notch. Results: There were significant reductions of anterior laxity of 3.5 mm at 20° of flexion, internal rotational laxity of 2.5° at 20° of flexion, and anterior translations (2 mm) and internal rotations (5°) in the simulated pivot-shift test in the double-bundle reconstruction com-pared with the single-bundle reconstruction. There were no significant differences between the 2 procedures for external rotation laxity. Conclusion: The postoperative anterior translation and internal rotation stability after anatomic double-bundle anterior cruciate ligament reconstruction were significantly better than after single-bundle reconstruction, in both static tests and the pivot shift. Clinical Relevance: Unlike previous laboratory studies, this work used clinical arthroscopic methods for anterior cruciate ligament reconstruction, and found that the anatomic reconstruction was superior to a single graft placed at 11 o’clock.
A tutorial on principal stratification-based sensitivity analysis: application to smoking cessation studies
Authors: Egleston Brian L , Cropsey Karen L , Lazev Amy B , Heckman Carolyn J 
Published: April 2010

Background One problem with assessing effects of smoking cessation interventions on withdrawal symptoms is that symptoms are affected by whether participants abstain from smoking during trials. Those who enter a randomized trial but do not change smoking behavior might not experience withdrawal-related symptoms. Purpose We present a tutorial of how one can use a principal stratification sensitivity analysis to account for abstinence in the estimation of smoking cessation intervention effects. The article is intended to introduce researchers to principal stratification and describe how they might implement the methods. Methods We provide a hypothetical example that demonstrates why estimating effects within observed abstention groups is problematic. We demonstrate how estimation of effects within groups defined by potential abstention that an individual would have in either arm of a study can provide meaningful inferences. We describe a sensitivity analysis method to estimate such effects, and use it to investigate effects of a combined behavioral and nicotine replacement therapy intervention on withdrawal symptoms in a female prisoner population. Results Overall, the intervention was found to reduce withdrawal symptoms but the effect was not statistically significant in the group that was observed to abstain. More importantly, the intervention was found to be highly effective in the group that would abstain regardless of intervention assignment. The effectiveness of the intervention in other potential abstinence strata depends on the sensitivity analysis assumptions. Limitations We make assumptions to narrow the range of our sensitivity analysis estimates. While appropriate in this situation, such assumptions might not be plausible in all situations. Conclusions A principal stratification sensitivity analysis provides a meaningful method of accounting for abstinence effects in the evaluation of smoking cessation interventions on withdrawal symptoms. Smoking researchers have previously recommended analyses in subgroups defined by observed abstention status in the evaluation of smoking cessation interventions. We believe that principal stratification analyses should replace such analyses as the preferred means of accounting for post-randomization abstinence effects in the evaluation of smoking cessation programs. Clinical Trials 2010; 7: 286—298. http://ctj.sagepub.com
The RNA interference pathway affects midgut infection- and escape barriers for Sindbis virus in Aedes aegypti
Authors: Khoo Cynthia CH , Piper Joseph , Sanchez-Vargas Irma , Olson Ken E , Franz Alexander WE 
Published: April 2010

Abstract

Background
The RNA interference (RNAi) pathway acts as an innate antiviral immune response in Aedes aegypti, modulating arbovirus infection of mosquitoes. Sindbis virus (SINV; family: Togaviridae, genus: Alphavirus) is an arbovirus that infects Ae. aegypti in the laboratory. SINV strain TR339 encounters a midgut escape barrier (MEB) during infection of Ae. aegypti. The nature of this barrier is not well understood. To investigate the role of the midgut as the central organ determining vector competence for arboviruses, we generated transgenic mosquitoes in which the RNAi pathway was impaired in midgut tissue of bloodfed females. We used these mosquitoes to reveal effects of RNAi impairment in the midgut on SINV replication, midgut infection and dissemination efficiencies, and mosquito longevity.

Results
As a novel tool for studying arbovirus-mosquito interactions, we engineered a transgenic mosquito line with an impaired RNAi pathway in the midgut of bloodfed females by silencing expression of the Aa-dcr2 gene. In midgut tissue of the transgenic Carb/dcr16 line, Aa-dcr2 expression was reduced ~50% between 1-7 days post-bloodmeal (pbm) when compared to the recipient mosquito strain. After infection with SINV-TR339EGFP, Aa-dcr2 expression levels were enhanced in both mosquito strains. In the RNAi pathway impaired mosquito strain SINV titers and midgut infection rates were significantly higher at 7 days pbm. There was also a strong tendency for increased virus dissemination rates among the transgenic mosquitoes. Between 7-14 days pbm, SINV was diminished in midgut tissue of the transgenic mosquitoes. Transgenic impairment of the RNAi pathway and/or SINV infection did not affect longevity of the mosquitoes.

Conclusions
We showed that RNAi impaired transgenic mosquitoes are a useful tool for studying arbovirus-mosquito interactions at the molecular level. Following ingestion by Ae. aegypti, the recombinant SINV-TR339EGFP was confronted with both MEB and a midgut infection barrier (MIB). Impairment of the RNAi pathway in the midgut strongly reduced both midgut barriers for the virus. This confirms that the endogenous RNAi pathway of Ae. aegypti modulates vector competence for SINV in the midgut. The RNAi pathway acts as a gatekeeper to the incoming virus by affecting infection rate of the midgut, intensity of infection, and dissemination from the midgut to secondary tissues.
Identification and characterization of NAGNAG alternative splicing in the moss Physcomitrella patens
Authors: Sinha Rileen , Zimmer Andreas D , Bolte Kathrin , Lang Daniel , Reski Ralf , Platzer Matthias , Rensing Stefan A , Backofen Rolf 
Published: April 2010

Abstract

Background
Alternative splicing (AS) involving tandem acceptors that are separated by three nucleotides (NAGNAG) is an evolutionarily widespread class of AS, which is well studied in Homo sapiens (human) and Mus musculus (mouse). It has also been shown to be common in the model seed plants Arabidopsis thaliana and Oryza sativa (rice). In one of the first studies involving sequence-based prediction of AS in plants, we performed a genome-wide identification and characterization of NAGNAG AS in the model plant Physcomitrella patens, a moss.

Results
Using Sanger data, we found 295 alternatively used NAGNAG acceptors in P. patens. Using 31 features and training and test datasets of constitutive and alternative NAGNAGs, we trained a classifier to predict the splicing outcome at NAGNAG tandem splice sites (alternative splicing, constitutive at the first acceptor, or constitutive at the second acceptor). Our classifier achieved a balanced specificity and sensitivity of ≥ 89%. Subsequently, a classifier trained exclusively on data well supported by transcript evidence was used to make genome-wide predictions of NAGNAG splicing outcomes. By generation of more transcript evidence from a next-generation sequencing platform (Roche 454), we found additional evidence for NAGNAG AS, with altogether 664 alternative NAGNAGs being detected in P. patens using all currently available transcript evidence. The 454 data also enabled us to validate the predictions of the classifier, with 64% (80/125) of the well-supported cases of AS being predicted correctly.

Conclusion
NAGNAG AS is just as common in the moss P. patens as it is in the seed plants A. thaliana and O. sativa (but not conserved on the level of orthologous introns), and can be predicted with high accuracy. The most informative features are the nucleotides in the NAGNAG and in its immediate vicinity, along with the splice sites scores, as found earlier for NAGNAG AS in animals. Our results suggest that the mechanism behind NAGNAG AS in plants is similar to that in animals and is largely dependent on the splice site and its immediate neighborhood.
Physical activity in pregnancy: a qualitative study of the beliefs of overweight and obese pregnant women
Authors: Weir Zoe , Bush Judith , Robson Stephen C , McParlin Catherine , Rankin Judith , Bell Ruth 
Published: April 2010

Abstract

Background
Whilst there has been increasing research interest in interventions which promote physical activity during pregnancy few studies have yielded detailed insights into the views and experiences of overweight and obese pregnant women themselves. The qualitative study described in this paper aimed to: (i) explore the views and experiences of overweight and obese pregnant women; and (ii) inform interventions which could promote the adoption of physical activity during pregnancy.

Methods
The study was framed by a combined Subtle Realism and Theory of Planned Behaviour (TPB) approach. This enabled us to examine the hypothetical pathway between beliefs and physical activity intentions within the context of day to day life. The study sample for the qualitative study was chosen by stratified, purposive sampling from a previous study of physical activity measurements in pregnancy. Research participants for the current study were recruited on the basis of Body Mass Index (BMI) at booking and parity. Semi-structured, in-depth interviews were conducted with 14 overweight and obese pregnant women. Data analysis was undertaken using a Framework Approach and was informed by TPB.

Results
Healthy eating was often viewed as being of greater importance for the health of mother and baby than participation in physical activity. A commonly cited motivator for maintaining physical activity during pregnancy is an aid to reducing pregnancy-related weight gain. However, participants often described how they would wait until the postnatal period to try and lose weight. A wide range of barriers to physical activity during pregnancy were highlighted including both internal (physical and psychological) and external (work, family, time and environmental). The study participants also lacked access to consistent information, advice and support on the benefits of physical activity during pregnancy.

Conclusions
Interventions to encourage recommended levels of physical activity in pregnancy should be accompanied by accessible and consistent information about the positive effects for mother and baby. More research is required to examine how to overcome barriers to physical activity and to understand which interventions could be most effective for overweight/obese pregnant women. Midwives should be encouraged to do more to promote activity in pregnancy.
Organic Transistors Based on Octamethylenetetrathiafulvalenes
Authors: Inoue Jun-ichi , Kanno Masato , Ashizawa Minoru , Seo Chayeon , Tanioka Akihiko , Mori Takehiko 
Published: April 2010

Abstract
Organic field-effect transistors (OFET) based on octamethylenetetrathiafulvalene (OMTTF) and the t-butyl derivative are investigated. The parent OMTTF shows poor transistor performance owing to the flat molecular arrangement, but the t-butyl substitution realizes standing molecular arrangement and high OFET performance. The tetracyanoquinodimethane (TCNQ) complex of OMTTF exhibits n-channel properties despite the strong donor ability of OMTTF.
Magnetorheology of Magnetic Poly(vinyl alcohol) Gels with High Mechanical Toughness
Authors: Negami Keisuke , Mitsumata Tetsu 
Published: April 2010

Abstract
A magnetic-field-sensitive gel that demonstrates both drastic changes in dynamic modulus and high mechanical toughness was obtained. The magnetic gel consists of cross-linked poly(vinyl alcohol) (PVA), iron oxide particles, and water. The storage and loss shear moduli of the magnetic gel remarkably increased by applying a magnetic field, similarly to magnetic carrageenan gels. Compression revealed high mechanical toughness of the magnetic PVA gel and the maximum strain of 0.64 was achieved without inducing permanent strain.