bluuebunny/crossref_metadata_2025_split huggingface dataset:
Great Salt Lake–Effect Precipitation: Observed Frequency, Characteristics, and Associated Environmental Factors
Authors: Alcott Trevor I. , Steenburgh W. James , Laird Neil F. 
Published: April 2012

Abstract
This climatology examines the environmental factors controlling the frequency, occurrence, and morphology of Great Salt Lake–effect (GSLE) precipitation events using cool season (16 September–15 May) Weather Surveillance Radar-1988 Doppler (WSR-88D) imagery, radiosonde soundings, and MesoWest surface observations from 1997/98 to 2009/10. During this period, the frequency of GSLE events features considerable interannual variability that is more strongly correlated to large-scale circulation changes than lake-area variations. Events are most frequent in fall and spring, with a minimum in January when the climatological lake surface temperature is lowest. Although forecasters commonly use a 16°C lake–700-hPa temperature difference (ΔT) as a threshold for GSLE occurrence, GSLE was found to occur in winter when ΔT was only 12.4°C. Conversely, GSLE is associated with much higher values of ΔT in the fall and spring. Therefore, a seasonally varying threshold based on a quadratic fit to the monthly minimum ΔT values during GSLE events is more appropriate than a single threshold value. A probabilistic forecast method based on the difference between ΔT and this seasonally varying threshold, 850–700-hPa relative humidity, and 700-hPa wind direction offers substantial improvement over existing methods, although forecast skill is diminished by temperature and moisture errors in operational models. An important consideration for forecasting because of their higher precipitation rates, banded features—with a horizontal aspect ratio of 6:1 or greater—dominate only 20% of the time that GSLE is occurring, while widespread, nonbanded precipitation is much more common. Banded periods are associated with stronger low-level winds and a larger lake–land temperature difference.
Trends in alcohol-related deaths in the EU countries in 1980–2003
Authors: Innamorati Marco , Pompili Maurizio , Martinotti Giovanni , Serafini Gianluca , Amore Mario , Lester David , Girardi Paolo , Janiri Luigi 
Published: April 2012

Aims: To explore temporal trends since 1980 in alcohol-related death for people resident in the European Union (EU) and to examine differences between EU members admitted prior to 2004 and new EU members admitted since 2004. Methods: The data were extracted from the World Health Organization’s European mortality database and the European Health for All database. Results: New EU members had higher rates of alcohol-related deaths (135.0 ± 18.48 vs 88.9 ± 18.93; t = −8.55 (d.f. = 46), p < .001) and higher death rates from alcohol abuse (whole population: 3.4 ± 1.24 vs 2.6 ± 0.12; t = −2.98 (d.f. = 23.45), p < .01; male population: 6.1 ± 2.17 vs 4.4 ± 0.19; t = −3.87 (d.f. = 23.35), p < .001) than early EU countries. However, a mortality gradient between groups of countries was visible only for female alcohol-related deaths when controlling for mortality rates from all causes. Multivariate regression analyses also indicated that alcohol-related deaths and alcohol consumption were associated negatively with the gross national product (GNP) of EU countries and positively with levels of urbanization. Conclusions: Alcohol-related deaths represent more than 10% of all EU mortality and confirm the importance of national prevention strategies for alcohol problems.
Expressions of P53 and CD68 in mouse liver with Schistosoma mansoni infection and the protective role of silymarin
Authors: Tousson Ehab , Beltagy Doha M , Gazia Maha Abo , Al-Behbehani Bahija 
Published: April 2012

Schistosomiasis is one of the major human parasitic diseases in many developing countries and is one of the causes of morbidity and mortality in the human population. The present work has been planned to study the histopathological and immunohistochemical expression of P53 and CD68 in mouse liver tissues experimentally infected with Schistosoma mansoni, in addition to the ameliorating role of silymarin. A total of 50 adult male mice were divided into 5 groups (10 animals each). Groups 1 and 2 were the control and silymarin groups, respectively, while group 3 was the infected group in which the mice were infected with S. mansoni live cercariae for 6 weeks. Groups 4 and 5 were the cotreated and posttreated groups, respectively, in which mice were infected with cercariae of S. mansoni and treated with silymarin during and after Schistosoma infection, respectively. The major histopathological lesions were variable numbers of perioval granulomas, diffuse infiltration of inflammatory cells, mainly eosinophils and small mononuclear cells, and fibrosis of portal areas and interlobular septa. Treatment with silymarin led to a significant reduction in granuloma area in all treated infected mice compared with nontreated infected mice. Immunohistochemical observations of the liver tissues showed a significant increase in the apoptotic proteins P53 and CD68 after the infection with the cercariae of Schistosoma, compared with the control group. The expression of the cytoplasmic P53 and CD68 was very low in the control liver sections. A significant decrease in the expression of the cytoplasmic P53 and CD68 was observed after silymarin treatment.
Comparison of patients’ and clinicians’ views of the therapeutic relationship: a pilot project
Authors: Djurkov Anthony , Sertsou Liz 
Published: April 2012

Objective: Our aim was to find out whether psychiatrists’ views of the quality of the therapeutic relationship were shared by their patients, and to ascertain a feasible way to explore these relationships routinely. Method: Sixty-one outpatients selected by two receptionists completed the Helping Alliance Scale (HAS), client version and the Relationship Questionnaire. The two participating psychiatrists were not involved in patient selection and were blind to patients’ responses. They recorded their view of the relationships using the clinician version of HAS. The Big Five Inventory and Relationship Questionnaire were also utilized. Without identifying patients, each psychiatrist analysed the data of the other clinician. Results: Both clinicians had an agreement rate above 75%. The differences in the details reflected gender and personality differences. There was no benchmark with which to compare these results. Conclusions: Assessing and recording the therapeutic relationship in community practice is feasible and provides invaluable knowledge. The next challenge is to consider whether and how this could be done routinely.
Nasopharyngeal Disease in Cats
Authors: Reed Nicki , Gunn-Moore Danièlle 
Published: April 2012

Practical relevance: Nasopharyngeal disease is a common presenting problem in feline medicine. Clinical challenges: The management of feline nasopharyngeal disease can be challenging at a number of levels. In many cases, a specific diagnosis may remain elusive. Some conditions may not be curable so owners need to understand the requirement for long-term management. In addition, treatment may be compromised by poor patient compliance. Audience: This review, which is directed at any clinicians involved in the management of cats with nasopharyngeal disease, discusses acute rhinitis (cat ’flu) and a variety of conditions causing chronic rhinosinusitis/chronic nasopharyngeal disease. The intention is to assist treatment decision making by reviewing the most appropriate therapies from the options available for these patients. Evidence base: The information presented in this article is based on peer-reviewed publications and the clinical experience of the authors.
AAFP and ISFM Feline-Friendly Nursing Care Guidelines
Authors: Carney Hazel C , Little Susan , Brownlee-Tomasso Dawn , Harvey Andrea M , Mattox Erica , Robertson Sheilah , Rucinsky Renee , Manley Donna Stephens 
Published: April 2012

Nursing care: The term nursing care means different things to different people. The authors of these AAFP and ISFM Feline-Friendly Nursing Care Guidelines define nursing care as any interaction between the cat and the veterinary team (veterinarian, technician or nurse, receptionist or other support staff) in the clinic, or between the cat and its owner at home, that promotes wellness or recovery from illness or injury and addresses the patient’s physical and emotional wellbeing. Nursing care also helps the sick or convalescing cat engage in activities that it would be unable to perform without help. Guidelines rationale: The purpose of the Guidelines is to help all members of the veterinary team understand the basic concepts of nursing care, both in the clinic and at home. This includes methods for keeping the patient warm, comfortable, well nourished, clean and groomed. The Guidelines provide numerous practical tips gleaned from the authors’ many years of clinical experience and encourage veterinary team members to look at feline nursing care in ways they previously may not have considered. Overarching goal: The primary goal of feline-friendly nursing care is to make the cat feel safe and secure throughout its medical experience.
Environment correspondents in China in their own words: Their perceptions of their role and the possible consequences of their journalism
Authors: de Burgh Hugo , Zeng Rong 
Published: April 2012

There is widespread dismay at the effects of Chinese economic development on the environment. The government is cognisant of the issues and seeking to raise awareness. Among the means are the media, such that a new specialism has appeared in China in recent years, that of the environment correspondent. This study gives voice to these specialists in order to understand their attitudes towards the environment, their means of operation and their views on the significance of their own work. The findings of the study are that Chinese environment correspondents are tentatively exploiting the opportunities that the government’s worry about the environment may give them, even as they doubt their capacity to respond adequately to the challenges posed by taking the environment seriously and the responsibility for raising awareness and identifying transgressions. Just as journalists became the evangelists of China’s economic revolution, so they may be becoming the promoters of environment awareness. In the course of so doing, it may be that they are among those contributing to a new consensus about how decisions are being taken, and should be made, in their society.
Medication management: The perspectives of people with dementia and family carers
Authors: While Christine , Duane Fleur , Beanland Christine , Koch Susan 
Published: April 2012

The safe self management of medicines will be affected by the presence of dementia. A qualitative study using grounded theory was undertaken by a community nursing organisation in Melbourne, Australia, in order to develop a strength-based and person-centred approach to the assessment of medication ability. The perspectives of the person with dementia and their carers were explored to see if there were any significant differences in their medication management experiences when compared to those of older adults without dementia and their carers. People with dementia are able to sustain self management of their medicines using established routines and strategies. As cognitive changes affect short-term memory, external strategies and task allocation to family members are introduced by the individual to support their continuing independence. The family member assumed the carer role as their concern for medication safety increased, but this role engendered stress and a burden that was unacknowledged by the health professional.
Clinical features and outcome of multiple primary malignancies involving hepatocellular carcinoma: A long-term follow-up study
Authors: Zeng Qing-An , Qiu Jiliang , Zou Ruhai , Li Yijie , Li Shengping , Li Binkui , Huang Pinzhu , Hong Jian , Zheng Yun , Lao Xiangming , Yuan Yunfei 
Published: April 2012

Abstract

Background
The prolonged survival of individuals diagnosed with cancer has led to an increase in the number of secondary primary malignancies. We undertook to perform a definitive study to characterize and predict prognosis of multiple primary malignancies (MPM) involving hepatocellular carcinoma (HCC), due to the scarcity of such reports.

Methods
Clinicopathological data were analyzed for 68 MPM patients involving HCC, with 35 (target group) underwent curative liver resection. Additional 140 HCC-alone patients with hepatectomy were selected randomly during the same period as the control group.

Results
Of the 68 patients with extrahepatic primary malignancies (EHPM), 22 were diagnosed synchronously with HCC, and 46 metachronously. The most frequent EHPM was nasophargeal carcinoma, followed by colorectal and lung cancer. Univariate analysis demonstrated that synchronous (P = 0.008) and non-radical treatment for EHPM (P < 0.001) were significant risk factors associated with poorer overall survival (OS). While, Cox modeling revealed that the treatment modality for EHPM, but not the synchronous/metachronous determinant, was an independent factor for OS, and that therapeutic option for HCC was an independent factor for HCC-specific OS. Moreover, no HCC-specific overall and recurrence-free survival benefit were observed in the control group when compared with that of the target group (P = 0.607, P = 0.131, respectively).

Conclusions
Curative treatment is an independent predictive factor for OS and HCC-specific OS, and should been taken into account both for synchronous and metachronous patients. MPM patients involving HCC should not be excluded from radical resection for HCC.
Geo-mapping of time trends in childhood caries risk a method for assessment of preventive care
Authors: Strömberg Ulf , Holmn Anders , Magnusson Kerstin , Twetman Svante 
Published: April 2012

Abstract

Background
Dental caries is unevenly distributed within populations with a higher burden in low socio-economy groups. Several attempts have been made to allocate resources to those that need them the most; there is a need for convenient approaches to population-based monitoring of caries risk over time. The aim of this study was to develop the geo-map concept, addressing time trends in caries risk, and demonstrate the novel approach by analyzing epidemiological data from preschool residents in the region of Halland, Sweden.

Methods
The study population consisted of 9,973 (2006) and 10,927 (2010) children between 3 to 6years of age (~77% of the eligible population) from whom caries data were obtained. Reported dmfs>0 for a child was considered as the primary caries outcome. Each study individual was geo-coded with respect to his/her residence parish (66 parishes in the region). Smoothed caries risk geo-maps, along with corresponding statistical certainty geo-maps, were produced by using the free software Rapid Inquiry Facility and the ESRI ArcGIS system. Parish-level socioeconomic data were available.

Results
The overall proportion of caries-free (dmfs=0) children improved from 84.0% in 2006 to 88.6% in 2010. The ratio of maximum and minimum (parish-level) smoothed relative risks (SmRRs) increased from 1.76/0.44=4.0 in 2006 to 2.37/0.33=7.2 in 2010, which indicated an increased geographical polarization of early childhood caries in the population. Eight parishes showed evidential, positional changes in caries risk between 2006 and 2010; their corresponding SmRRs and statistical certainty ranks changed markedly. No considerable parallel changes in parish-level socioeconomic characteristics were seen during the same time period.

Conclusion
Geo-maps based on caries risk can be used to monitor changes in caries risk over time. Thus, geo-mapping offers a convenient tool for evaluating the effectiveness of tailored health promotion and preventive care in child populations.
Influence of the relative composition of trace elements and vitamins in physicochemical stability of total parenteral nutrition formulations for neonatal use
Authors: Lobo Bianca W , da Veiga Venício F , Cabral Lúcio M , Michel Ricardo C , Volpato Nádia M , de Sousa Valéria P 
Published: April 2012

Abstract

Objective
The present study aimed to evaluate the influence of the relative composition of trace elements and vitamins in physicochemical stability of neonatal parenteral nutrition.

Material and methods
Three formulations for neonatal administration were selected; the main variable was the presence of trace elements and vitamins. The analyses where carried out immediately after preparation and at 24 h, 48 h, 72 h and 7 days after preparation. Three methods were selected to determine globule size: light obscuration, dynamic light scattering and optical microscopy. Complementary evaluation including visual inspection, determination of pH and osmolarity, peroxide levels and measurements of zeta potential were also performed.

Results
There was an observable alteration in color and phase separation in the PN stored at 25°C and 40°C. Neither globule size pattern, nor any other physicochemical characteristic evaluated appeared to be considerably altered in any of the analyzed formulations even after 7 days of storage at 5°C. Globule size in all the PN studied was consistent with the established limit, below 500 nm by DLS measurement, and PFAT5 was below 0.05% under all storage temperatures.

Conclusion
Concomitant presence of trace elements and vitamins in the same neonatal formulation did not alter the evaluated aspects of stability.
The cytotoxicity of polycationic iron oxide nanoparticles: Common endpoint assays and alternative approaches for improved understanding of cellular response mechanism
Authors: Hoskins Clare , Cuschieri Alfred , Wang Lijun 
Published: April 2012

Abstract

Background
Iron oxide magnetic nanoparticles (MNP's) have an increasing number of biomedical applications. As such in vitro characterisation is essential to ensure the bio-safety of these particles. Little is known on the cellular interaction or effect on membrane integrity upon exposure to these MNPs. Here we synthesised Fe3O4 and surface coated with poly(ethylenimine) (PEI) and poly(ethylene glycol) (PEG) to achieve particles of varying surface positive charges and used them as model MNP's to evaluate the relative utility and limitations of cellular assays commonly applied for nanotoxicity assessment. An alternative approach, atomic force microscopy (AFM), was explored for the analysis of membrane structure and cell morphology upon interacting with the MNPs. The particles were tested in vitro on human SH-SY5Y, MCF-7 and U937 cell lines for reactive oxygen species (ROS) production and lipid peroxidation (LPO), LDH leakage and their overall cytotoxic effect. These results were compared with AFM topography imaging carried out on fixed cell lines.

Results
Successful particle synthesis and coating were characterised using FTIR, PCS, TEM and ICP. The particle size from TEM was 30 nm (−16.9 mV) which increased to 40 nm (+55.6 mV) upon coating with PEI and subsequently 50 nm (+31.2 mV) with PEG coating. Both particles showed excellent stability not only at neutral pH but also in acidic environment of pH 4.6 in the presence of sodium citrate. The higher surface charge MNP-PEI resulted in increased cytotoxic effect and ROS production on all cell lines compared with the MNP-PEI-PEG. In general the effect on the cell membrane integrity was observed only in SH-SY5Y and MCF-7 cells by MNP-PEI determined by LDH leakage and LPO production. AFM topography images showed consistently that both the highly charged MNP-PEI and the less charged MNP-PEI-PEG caused cell morphology changes possibly due to membrane disruption and cytoskeleton remodelling.

Conclusions
Our findings indicate that common in vitro cell endpoint assays do not give detailed and complete information on cellular state and it is essential to explore novel approaches and carry out more in-depth studies to elucidate cellular response mechanism to magnetic nanoparticles.
Carbon nanotube counter electrode for high-efficient fibrous dye-sensitized solar cells
Authors: Huang Shuqing , Sun Huicheng , Huang Xiaoming , Zhang Quanxin , Li Dongmei , Luo Yanhong , Meng Qingbo 
Published: April 2012

Abstract
High-efficient fibrous dye-sensitized solar cell with carbon nanotube (CNT) thin films as counter electrodes has been reported. The CNT films were fabricated by coating CNT paste or spraying CNT suspension solution on Ti wires. A fluorine tin oxide-coated CNT underlayer was used to improve the adherence of the CNT layer on Ti substrate for sprayed samples. The charge transfer catalytic behavior of fibrous CNT/Ti counter electrodes to the iodide/triiodide redox pair was carefully studied by electrochemical impedance and current-voltage measurement. The catalytic activity can be enhanced by increasing the amount of CNT loading on substrate. Both the efficiencies of fibrous dye-sensitized solar cells using paste coated and sprayed CNT films as counter electrodes are comparative to that using Pt wires, indicating the feasibility of CNT/Ti wires as fibrous counter electrode for superseding Pt wires.
Aging, cancer, and cancer vaccines
Authors: Mazzola Paolo , Radhi Saba , Mirandola Leonardo , Annoni Giorgio , Jenkins Marjorie , Cobos Everardo , Chiriva-Internati Maurizio 
Published: April 2012

AbstractWorld population has experienced continuous growth since 1400 A.D. Current projections show a continued increase - but a steady decline in the population growth rate - with the number expected to reach between 8 and 10.5 billion people within 40 years. The elderly population is rapidly rising: in 1950 there were 205 million people aged 60 or older, while in 2000 there were 606 million. By 2050, the global population aged 60 or over is projected to expand by more than three times, reaching nearly 2 billion people [1]. Most cancers are age-related diseases: in the US, 50% of all malignancies occur in people aged 65-95. 60% of all cancers are expected to be diagnosed in elderly patients by 2020 [2]. Further, cancer-related mortality increases with age: 70% of all malignancy-related deaths are registered in people aged 65 years or older [3]. Here we introduce the microscopic aspects of aging, the pro-inflammatory phenotype of the elderly, and the changes related to immunosenescence. Then we deal with cancer disease and its development, the difficulty of treatment administration in the geriatric population, and the importance of a comprehensive geriatric assessment. Finally, we aim to analyze the complex interactions of aging with cancer and cancer vaccinology, and the importance of this last approach as a complementary therapy to different levels of prevention and treatment. Cancer vaccines, in fact, should at present be recommended in association to a stronger cancer prevention and conventional therapies (surgery, chemotherapy, radiation therapy), both for curative and palliative intent, in order to reduce morbidity and mortality associated to cancer progression.