bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cilostazol protects against gastric ulcers by regulating PPAR-γ, HO-1, PECAM-1, pErk-1, NF-κB, Bcl-2, and cleaved caspase-3 protein expression
Authors: El-Shitany Nagla A. , EL-saidy Eman A. , EL-Naggar Mostafa E. , Sokar Samia S. 
Published: June 2024

AbstractMillions of individuals worldwide, across all age groups, suffer from the widespread health issue of gastric ulcers. In many experiments, cilostazol (Cls), a phosphodiesterase-3 inhibitor, was recently shown to have anti-ulcer activity. Notably, Cls increases the expression and transcriptional activity of PPAR-γ in vitro and in vivo. This study aimed to evaluate the protective effect of Cls against ethanol-induced gastric ulcers and clarify the possible underlying mechanisms with an emphasis on the role of PPAR-γ. Male albino rats were treated with ethanol to induce gastric ulcers, or they were pretreated with Cls, omeprazole (Omp), GW9662, or Cls + GW9662 for 14 consecutive days before receiving ethanol. Cls protects against ethanol-induced gastric ulcers. Cls treatment significantly reduced ethanol-induced upregulation of the pro-inflammatory markers (IL-1β, IL-6, TNF-α, and NF-κB), MDA (a marker of lipid peroxidation), and caspase-3 and cleaved caspase-3 (apoptotic markers). On the other hand, Cls treatment counteracted ethanol-induced downregulation of PPAR-γ, pErk-1, HO-1 and GSH (antioxidant markers), PECAM-1 and NO (healing markers), and Bcl-2 (antiapoptotic marker). However, when combined with GW9662, a potent antagonist of PPAR-γ, Cls loses its effects. In conclusion, these results suggest that PPAR-γ and pErk-1 are essential for Cls’s protective effects against ethanol-induced gastric ulcers.
Graphical abstract
Investigating the tamoxifen/high-fat diet synergy: a promising paradigm for nonalcoholic steatohepatitis induction in a rat model
Authors: Ezz-Eldin Yousra M. , Ewees Mohamed G. , Azouz Amany A. , Khalaf Marwa M. 
Published: June 2024

AbstractNon-alcoholic steatohepatitis (NASH) is a severe liver condition characterized by excessive fat deposition, ballooning, and lobular inflammation. This investigation was conducted to estimate the capability of concomitant tamoxifen administration (TAM) with a high fat diet (HFD) to induce a reliable NASH model that mimics human NASH features. Rats were administered TAM (25 mg/kg/day p.o.) and consumed HFD for 5 weeks. A time-course investigation was conducted to determine the optimal time for NASH development. Liver function indices, hepatic lipid profile factors, oxidative stress biomarkers, and inflammatory mediators were estimated. Additionally, macroscopic and microscopic changes were examined. Compared with the time-matched control group receiving vehicle alone, TAM/HFD significantly impaired liver function indices represented as marked elevation in ALT, AST, and ALP serum levels. TAM/HFD significantly increased lipid profile factors including high TG and TC hepatic levels. Additionally, TAM/HFD remarkably raised hepatic levels of TNF-α and IL-17 and significantly decreased IL-10. The combination also increases the oxidative status evidenced by high content of MDA as well as low activity of GPx and SOD. Accordingly, the combination of TAM and HFD for 5 weeks collaboratively promotes NASH development by initiating compromised hepatocyte functionality, elevated lipid levels, oxidative stress, and liver inflammation.
Graphical abstract
CIRSE Standards of Practice on Portal Vein Embolization and Double Vein Embolization/Liver Venous Deprivation
Authors: Bilhim Tiago , Böning Georg , Guiu Boris , Luz José Hugo , Denys Alban 
Published: June 2024

AbstractThis CIRSE Standards of Practice document is aimed at interventional radiologists and provides best practices for performing liver regeneration therapies prior to major hepatectomies, including portal vein embolization, double vein embolization and liver venous deprivation. It has been developed by an expert writing group under the guidance of the CIRSE Standards of Practice Committee. It encompasses all clinical and technical details required to perform liver regeneration therapies, revising the indications, contra-indications, outcome measures assessed, technique and expected outcomes.
Erythema nodosum
Authors: Weber Viktoria , Weimann Konstantin , Kolm Isabel , Meier-Schiesser Barbara 
Published: June 2024

ZusammenfassungDas Erythema nodosum (EN) ist die am häufigsten auftretende Form einer akuten Pannikulitis. Es wird charakterisiert durch schmerzhafte, rote bis livide, erhabene Knötchen oder Beulen, die typischerweise symmetrisch im Bereich der Schienbeine auftreten. Häufig handelt es sich beim EN um eine Reaktion des Immunsystems auf Infektionen, entzündliche Erkrankungen oder Medikamente. In etwa der Hälfte der Fälle ist kein Auslöser zu eruieren. Nach Behandlung der zugrunde liegenden Ursache ist das EN in der Regel selbstlimitierend.
Brain vasculature accumulates tau and is spatially related to tau tangle pathology in Alzheimer’s disease
Authors: Hoglund Zachary , Ruiz-Uribe Nancy , del Sastre Eric , Woost Benjamin , Bader Elizabeth , Bailey Joshua , Hyman Bradley T. , Zwang Theodore , Bennett Rachel E. 
Published: June 2024

AbstractInsoluble pathogenic proteins accumulate along blood vessels in conditions of cerebral amyloid angiopathy (CAA), exerting a toxic effect on vascular cells and impacting cerebral homeostasis. In this work, we provide new evidence from three-dimensional human brain histology that tau protein, the main component of neurofibrillary tangles, can similarly accumulate along brain vascular segments. We quantitatively assessed n = 6 Alzheimer’s disease (AD), and n = 6 normal aging control brains and saw that tau-positive blood vessel segments were present in all AD cases. Tau-positive vessels are enriched for tau at levels higher than the surrounding tissue and appear to affect arterioles across cortical layers (I–V). Further, vessels isolated from these AD tissues were enriched for N-terminal tau and tau phosphorylated at T181 and T217. Importantly, tau-positive vessels are associated with local areas of increased tau neurofibrillary tangles. This suggests that accumulation of tau around blood vessels may reflect a local clearance failure. In sum, these data indicate that tau, like amyloid beta, accumulates along blood vessels and may exert a significant influence on vasculature in the setting of AD.
Seeding activity of human superoxide dismutase 1 aggregates in familial and sporadic amyotrophic lateral sclerosis postmortem neural tissues by real-time quaking-induced conversion
Authors: Mielke Justin K. , Klingeborn Mikael , Schultz Eric P. , Markham Erin L. , Reese Emily D. , Alam Parvez , Mackenzie Ian R. , Ly Cindy V. , Caughey Byron , Cashman Neil R. , Leavens Moses J. 
Published: June 2024

AbstractAmyotrophic lateral sclerosis (ALS) is a rapidly progressive neurodegenerative disease with average lifespan of 2–5 years after diagnosis. The identification of novel prognostic and pharmacodynamic biomarkers are needed to facilitate therapeutic development. Metalloprotein human superoxide dismutase 1 (SOD1) is known to accumulate and form aggregates in patient neural tissue with familial ALS linked to mutations in their SOD1 gene. Aggregates of SOD1 have also been detected in other forms of ALS, including the sporadic form and the most common familial form linked to abnormal hexanucleotide repeat expansions in the Chromosome 9 open reading frame 72 (C9ORF72) gene. Here, we report the development of a real-time quaking-induced conversion (RT-QuIC) seed amplification assay using a recombinant human SOD1 substrate to measure SOD1 seeding activity in postmortem spinal cord and motor cortex tissue from persons with different ALS etiologies. Our SOD1 RT-QuIC assay detected SOD1 seeds in motor cortex and spinal cord dilutions down to 10–5. Importantly, we detected SOD1 seeding activity in specimens from both sporadic and familial ALS cases, with the latter having mutations in either their SOD1 or C9ORF72 genes. Analyses of RT-QuIC parameters indicated similar lag phases in spinal cords of sporadic and familial ALS patients, but higher ThT fluorescence maxima by SOD1 familial ALS specimens and sporadic ALS thoracic cord specimens. For a subset of sporadic ALS patients, motor cortex and spinal cords were examined, with seeding activity in both anatomical regions. Our results suggest SOD1 seeds are in ALS patient neural tissues not linked to SOD1 mutation, suggesting that SOD1 seeding activity may be a promising biomarker, particularly in sporadic ALS cases for whom genetic testing is uninformative.
Type 2 Biomarkers and Their Clinical Implications in Bronchiectasis: A Prospective Cohort Study
Authors: Chen Yen-Fu , Hou Hsin-Han , Chien Ning , Lu Kai-Zen , Chen Ying-Yin , Hung Zheng-Ci , Chien Jung-Yien , Wang Hao-Chien , Yu Chong-Jen 
Published: June 2024

Abstract
Purpose
Bronchiectasis is predominantly marked by neutrophilic inflammation. The relevance of type 2 biomarkers in disease severity and exacerbation risk is poorly understood. This study explores the clinical significance of these biomarkers in bronchiectasis patients.

Methods
In a cross-sectional cohort study, bronchiectasis patients, excluding those with asthma or allergic bronchopulmonary aspergillosis, underwent clinical and radiological evaluations. Bronchoalveolar lavage samples were analyzed for cytokines and microbiology. Blood eosinophil count (BEC), serum total immunoglobulin E (IgE), and fractional exhaled nitric oxide (FeNO) were measured during stable disease states. Positive type 2 biomarkers were defined by established thresholds for BEC, total IgE, and FeNO.

Results
Among 130 patients, 15.3% demonstrated BEC ≥ 300 cells/μL, 26.1% showed elevated FeNO ≥ 25 ppb, and 36.9% had high serum total IgE ≥ 75 kU/L. Approximately 60% had at least one positive type 2 biomarker. The impact on clinical characteristics and disease severity was variable, highlighting BEC and FeNO as reflective of different facets of disease severity and exacerbation risk. The combination of low BEC with high FeNO appeared to indicate a lower risk of exacerbation. However, Pseudomonas aeruginosa colonization and a high neutrophil-to-lymphocyte ratio (NLR ≥ 3.0) were identified as more significant predictors of exacerbation frequency, independent of type 2 biomarker presence.

Conclusions
Our study underscores the distinct roles of type 2 biomarkers, highlighting BEC and FeNO, in bronchiectasis for assessing disease severity and predicting exacerbation risk. It advocates for a multi-biomarker strategy, incorporating these with microbiological and clinical assessments, for comprehensive patient management.
Note on dose conversion for radon exposure
Authors: Beck Thomas R. 
Published: June 2024

AbstractThe epidemiological approach to converting radon exposure to effective dose is examined. Based on the definition of the effective dose, the dose conversion is obtained from the equivalence of lung-specific detriment associated with low-LET radiation and with radon exposure. This approach most reliably estimates effective dose per radon exposure on the basis of epidemiological data and implicitly includes the radiation weighting factor required to calculate the effective dose from radon exposure using the dosimetric approach, applying biokinetic and dosimetric models. Consistency between the results of the epidemiological and dosimetric approaches is achieved by using a radiation weighting factor of about 10 for alpha particles instead of the current ICRP value of 20. In contrast, the epidemiological approach implemented in ICRP 65, and referred to as dose conversion convention, was based on direct comparison of total radiation detriment with lung detriment from radon exposure. With the revision of radiation detriments in ICRP 103, this approach can be judged to overestimate the effective dose per radon exposure by about a factor of two because the tissue weighting factor for lung differs from the value of relative detriment to which it relates.
Interpolation-based immersogeometric analysis methods for multi-material and multi-physics problems
Authors: Fromm Jennifer E. , Wunsch Nils , Maute Kurt , Evans John A. , Chen Jiun-Shyan 
Published: June 2024

AbstractImmersed boundary methods are high-order accurate computational tools used to model geometrically complex problems in computational mechanics. While traditional finite element methods require the construction of high-quality boundary-fitted meshes, immersed boundary methods instead embed the computational domain in a structured background grid. Interpolation-based immersed boundary methods augment existing finite element software to non-invasively implement immersed boundary capabilities through extraction. Extraction interpolates the structured background basis as a linear combination of Lagrange polynomials defined on a foreground mesh, creating an interpolated basis that can be easily integrated by existing methods. This work extends the interpolation-based immersed isogeometric method to multi-material and multi-physics problems. Beginning from level-set descriptions of domain geometries, Heaviside enrichment is implemented to accommodate discontinuities in state variable fields across material interfaces. Adaptive refinement with truncated hierarchically refined B-splines (THB-splines) is used to both improve interface geometry representations and to resolve large solution gradients near interfaces. Multi-physics problems typically involve coupled fields where each field has unique discretization requirements. This work presents a novel discretization method for coupled problems through the application of extraction, using a single foreground mesh for all fields. Numerical examples illustrate optimal convergence rates for this method in both 2D and 3D, for partial differential equations representing heat conduction, linear elasticity, and a coupled thermo-mechanical problem. The utility of this method is demonstrated through image-based analysis of a composite sample, where in addition to circumventing typical meshing difficulties, this method reduces the required degrees of freedom when compared to classical boundary-fitted finite element methods.
The interplay between teachers’ value-related educational goals and their value-related school climate over time
Authors: Oeschger Thomas P. , Makarova Elena , Raman Evren , Hayes Beatrice , Döring Anna K. 
Published: June 2024

AbstractValues education within the school context is, among other elements, shaped by a value-related school climate as well as teachers’ value-related educational goals. This longitudinal study investigated the interplay between these two elements over fifteen months, starting in March 2021, and including four points of measurement (t1 − t4). The sample consisted of 118 primary school teachers (years 1 and 2) from primary schools in Switzerland. Teachers’ value-related educational goals were measured with the Portrait Values Questionnaire, and teachers’ perception of their school climate was measured with the 12-Item School Climate Measure Scale. Random Intercept Cross-Lagged Panel Models along with Multiple Imputation for missing data were used to investigate the reciprocal relationships along the four dimensions of value-related educational goals represented by Schwartz’s Higher-Order Value Types: Openness to Change, Conservation, Self-Enhancement, and Self-Transcendence and their corresponding dimensions of a perceived value-related school climate of Innovation, Stability, Performance, and Support. For the dimensions “Innovation and Openness to Change,” the analyses revealed that the perceived value-related school climate of Innovation predicted teachers’ value-related educational goals of Openness to Change significantly from t1 to t2, while an effect in the opposite direction from t2 to t3 and from t3 to t4 was found. For the dimension “Stability and Conservation,” the analyses revealed that the perceived value-related school climate of Stability predicted teachers’ value-related educational goals of Conservation from t3 to t4. These findings are discussed in light of the dynamic processes of values education within the school environment as well as in the context of environmental and societal developments.
Is there such a thing as felicitous underspecification?
Authors: Speaks Jeff 
Published: June 2024

AbstractIn Felicitous Underspecification, Jeffrey King draws our attention to a rich and underexplored collection of linguistic data. These are uses of context-sensitive expressions which seem perfectly felicitous despite being such that, on plausible assumptions, the context in which they are used falls short of securing for them a unique semantic value. This raises an immediate puzzle: if, as King argues, these uses of expressions really do lack unique semantic values in context, how can they—as they manifestly do—make contributions to the conversations in which they occur? King answers this question with a novel theory of conversational updating. Here I focus less on this theory than on King’s examples, and consider some ways of accommodating them without positing felicitous underspecification. In some cases I give some reasons for thinking that the alternative explanation is superior. But my aim is less to establish this conclusion than to suggest some new options for thinking about these examples, and hopefully by so doing to advance the conversation about the data to which King has drawn our attention.
Children’s Experiences of Undergoing Forensic Interviews and Forensic Medical Examinations in a Danish Child Advocacy Center
Authors: Haahr-Pedersen Ida , Bach Maria Hardeberg , Banner Jytte , Spitz Pernille , Balsløv Maria , Perera Camila , Bramsen Rikke Holm , Hansen Maj 
Published: June 2024

AbstractChild abuse is a severe global problem associated with various negative consequences. It is therefore important that the services received at Child Advocacy Centers (CACs) are perceived as positive as possible by children affected by abuse. Preliminary research indicates that CACs are successful in terms of providing coordinated, professional services. However, existing research has primarily focused on service and criminal justice system outputs, rather than documenting the experiences of the target group: i.e., children undergoing the CAC proceedings. The present study seeks to investigate the children’s experiences of the forensic procedures in a CAC. Qualitative interviews were conducted with 15 children undergoing case proceedings at a Danish CAC. The overall experiences of the children of the forensic interview and forensic medical examination were documented. Additionally, five overall themes were constructed using Thematic Analysis: Localities and surroundings, Relational and communicative work, Ambivalent experiences, Need of information and overview, and Missing out on everyday life. The findings of the current study underline the importance of the physical environment of the CAC, the need of information and overview as well as strong relational and communicative skills among professional as core elements in establishing positive encounters with the CAC. Furthermore, the results indicate how negative experiences of visiting a CAC are not necessarily directly linked to the CAC but may be a result of the children experiencing missing out on well-liked everyday activities. Altogether these results are important to consider when planning future CAC visits to support the well-being of the child.
SPEI-FL: Serverless Privacy Edge Intelligence-Enabled Federated Learning in Smart Healthcare Systems
Authors: Akter Mahmuda , Moustafa Nour , Turnbull Benjamin 
Published: June 2024

AbstractSmart healthcare systems promise significant benefits for fast and accurate medical decisions. However, working with personal health data presents new privacy issues and constraints that must be solved from a cybersecurity perspective. Edge intelligence-enabled federated learning is a new scheme that utilises decentralised computing that allows data analytics to be carried out at the edge of a network, enhancing data privacy. However, this scheme suffers from privacy attacks, including inference, free-riding, and man-in-the-middle attacks, especially with serverless computing for allocating resources to user needs. Edge intelligence-enabled federated learning requires client data insertion and deletion to authenticate genuine clients and a serverless computing capability to ensure the security of collaborative machine learning models. This work introduces a serverless privacy edge intelligence-based federated learning (SPEI-FL) framework to address these issues. SPEI-FL includes a federated edge aggregator and authentication method to improve the data privacy of federated learning and allow client adaptation and removal without impacting the overall learning processes. It also can classify intruders through serverless computing processes. The proposed framework was evaluated with the unstructured COVID-19 medical chest x-rays and MNIST digit datasets, and the structured BoT-IoT dataset. The performance of the framework is comparable with existing authentication methods and reported a higher accuracy than comparable methods (approximately 90% as compared with the 81% reported by peer methods). The proposed authentication method prevents the exposure of sensitive patient information during medical device authentication and would become the cornerstone of the next generation of medical security with serverless computing.
No standard modifiable cardiovascular risk factors in acute myocardial infarction: prevalence, pathophysiology, and prognosis
Authors: Saito Yuichi , Tsujita Kenichi , Kobayashi Yoshio 
Published: June 2024

AbstractStandard modifiable cardiovascular risk factors (SMuRFs), such as hypertension, diabetes, dyslipidemia, and current smoking, are associated with the development of atherosclerotic cardiovascular diseases including acute myocardial infarction (MI). Thus, therapeutic approaches against SMuRFs are important as primary and secondary prevention of cardiovascular diseases. In patients with acute MI, however, the prognosis is counterintuitively poor when SMuRFs are lacking. The growing evidence has explored the prevalence, pathophysiology, and prognosis of SMuRF-less patients in acute MI and suggested the potential underlying mechanisms. This review article summarizes the clinical evidence and relevance of the lack of SMuRFs in acute MI.
Integrated wellbore-reservoir modeling based on 3D Navier–Stokes equations with a coupled CFD solver
Authors: Ahammad Jalal M. , Rahman Mohammad Azizur , Butt Stephen D. , Alam Jahrul M. 
Published: June 2024

AbstractThe occurrence of fluid flow near a wellhead is the major concern of the petroleum industry, as pressure drop, loss of formation, and other variables of interest are mostly affected in this region. The fluid flows from the hydrocarbon reservoir to the wellbore can be characterized as laminar to turbulent; thus, it is important to model this phenomenon with the integrated wellbore-reservoir model. Using 3D Navier–Stokes equations, an integrated wellbore-reservoir model is created in this study, and it incorporates the formation damage zone. For the porous-porous and porous-fluid interfaces, the General Grid Interface (GGI) approach is applied in conjunction with the conservative mass flux interface model. Model equations are solved using a velocity-pressure coupling solver that is pressure-based. For reliable and quick results, the system of equations is solved using an algebraic multigrid approach. The pressure diffusivity equation’s analytical solution under steady-state flow circumstances is used to validate the model. The integrated wellbore-reservoir model is applied to different reservoir scenarios, for example, different production rates, formation zones, and reservoir formation conditions. The results indicate that the present Computational Fluid Dynamics (CFD) model can be extended to simulate the real field scale model. integrated wellbore-reservoir modeling based on 3D Navier–Stokes equations with efficient computational techniques can lead the field of petroleum industries to advance current knowledge.