bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluating Extended Curettage and Adjuvant Therapy Against Wide Resection and Reconstruction in the Management of Distal Radius Giant Cell Tumors: A Systematic Review and Meta-analysis
Authors: Seth Ishith , Bulloch Gabriella , Lim Bryan , Xie Yi , Seth Nimish , Rozen Warren M. , Ng Sally Kiu-Huen 
Published: April 2024

Background: The management of distal radius giant cell tumors (GCTs) remains challenging, and the optimal approach is still a matter of debate. This systematic review and meta-analysis aimed to compare the outcomes of extended curettage and wide resection, the mainstays of treatment. Methods: Medline (via PubMed), Cochrane Library, Web of Science, Google Scholar, ClinicalTrials.gov, and Embase databases were searched for comparative studies that assessed extended curettage with adjuvant therapy and wide resection with reconstruction in patients with GCTs of the distal radius up to April 2023. Data were collected and analyzed on rates of local recurrence, metastasis, overall complications, and functional outcomes. The Newcastle-Ottawa scale was used to appraise the risk of bias within each study. Results: Fifteen studies (n = 373 patients) were included and analyzed. Patients who underwent curettage were more likely to develop recurrence (risk ratio [RR] = 3.02 [95% confidence interval; CI, 1.87-4.89], P < .01), showed fewer complications (RR = 0.32 [95% CI, 0.21-0.49], P < .01), and showed greater improvement in Visual Analog Scale and lower Disabilities of the Arm, Shoulder, and Hand scores ( P < .00001) than those who underwent wide resection. No significant difference was found regarding metastasis (RR = 1.03 [95% CI, 0.38-2.78], P = .95). Conclusions: Regarding the surgical approach to GCT of the distal radius, curettage with adjuvant therapy was associated with a higher likelihood of recurrence compared with wide resection with reconstruction. Nevertheless, the curettage approach resulted in significantly lower rates of operative complications, decreased pain scores, and better functional outcomes in comparison to the resection group.
A Living Lab for Family Centered Knowledge Exchange in Pediatric Rehabilitation and Development Research: A Study Protocol
Authors: Archibald Mandy M. , Akinwale Omolara , Hammond Elizabeth , Mora Aniela , Woodgate Roberta L. , Wittmeier Kristy 
Published: April 2024

Background Historically, the experiences and voices of children and youth living with neurodiversity or rehabilitation needs and their families have not been fully represented in health research. Formative research in this context indicates that families value learning from the experiences of other families as well as from empirical research. However, innovative systems are needed to support this imperative. In response, we co-designed a virtual living lab with families and clinicians to support family-centered knowledge exchange in neurodiversity and rehabilitation research. Living labs are collaborative, user-centered, long-term, and multimethod systems with potential to support the exchange of knowledge of lived experience. This proposal outlines a longitudinal arts-based and qualitative research study that incorporates storytelling as a powerful tool to elicit and exchange stories of lived experience through the virtual living lab, and subsequent usability testing of the platform. Methods and Analysis Stage 1- We will conduct an integrated knowledge translation study inclusive of user centered lab design and construction. Stage 2- We will conduct a 6-month longitudinal qualitative storytelling study with 30–40 participants including neurodiverse children and youth ages 5–19 years, their siblings, and parent/guardians, guided by the F-words framework which is based on the International Classification of Functioning, Disability, and Health. Following user-registration within the virtual lab, participants will complete a minimum of 1 story monthly, accompanied by an arts-based component, for 6 months. Conclusion Findings will inform the co-development of an arts-based knowledge translation resource to communicate key findings. Stage 3- A subset of families will be sampled to complete usability testing of the living lab platform and storytelling feature using a sequential explanatory mixed methods design. Usability evaluation will inform future platform refinements and provide indications of acceptability and use across subgroups.
Classification and measurement of displacement of isolated greater tuberosity fractures: Intra and interobserver reliability
Authors: Ismayl Ghiath , Ogbechie Catherine , Goundry Samuel , Budworth Luke , Ejiofor Ikechukwu , Sheikh Hassaan , McCormack Paul , Tunstall Charlotte , Philipson Mark , Cowling Paul 
Published: April 2024

Background Literature demonstrates variability in the amount of displacement of isolated greater tuberosity (GT) fractures and measurement techniques that orthopaedic surgeons deem warrant surgical intervention. This study aims to assess the intra and interobserver reliability for classifying and measuring the displacement amount for isolated GT fractures. Methods Eight surgeons, consisting of four shoulder specialists and four trainee surgeons, reviewed 25 plain radiographs on two separate occasions, 3 months apart. They were required to morphologically classify the GT fracture, measure the displacement distance on anteroposterior and axillary views, calculate the GT displacement ratio, and state whether they would offer surgical treatment. Results There was a lack of good reliability for the classification of the depression and avulsion fracture types. There was good intraobserver but poor interobserver consistency in classifying the split-type fractures. The measurement of the displacement distance showed good intraobserver reliability, but not as good interobserver agreement. Also, the displacement ratio calculated revealed poor consistency. We found good agreement between and within the raters for the treatment decision. No significant difference was noted when comparing the senior surgeons to the junior surgeons. Conclusions This study has revealed ongoing inconsistency in the classification and measurement of isolated GT fractures.
Development of a Real-time Force-based Algorithm for Infusion Failure Detection
Authors: Blanco Luis E. , Wilcox John H. , Hughes Michael S. , Lal Rayhan A. 
Published: April 2024

Background: Continuous subcutaneous insulin infusion (CSII) is a common treatment option for people with diabetes (PWD), but insulin infusion failures pose a significant challenge, leading to hyperglycemia, diabetes burnout, and increased hospitalizations. Current CSII pumps’ occlusion alarm systems are limited in detecting infusion failures; therefore, a more effective detection method is needed. Methods: We conducted five preclinical animal studies to collect data on infusion failures, utilizing both insulin and non-insulin boluses. Data were captured using in-line pressure and flow rate sensors, with additional force data from CSII pumps’ onboard sensors in one study. A novel classifier model was developed using this dataset, aimed at detecting different types of infusion failures through direct utilization of force sensor data. Performance was compared against various occlusion alarm thresholds from commercially available CSII pumps. Results: The testing dataset included 251 boluses. The Bagging classifier model showed the highest performance metrics among the models tested, exhibiting high accuracy (96%), sensitivity (94%), and specificity (98%), with lower false-positive and false-negative rate compared with traditional occlusion alarm pressure thresholds. Conclusions: Our study developed a novel non-threshold classifier that outperforms current occlusion alarm systems in CSII pumps in detecting infusion failures. This advancement has the potential to reduce the risk of hyperglycemia and hospitalizations due to undetected infusion failures, offering a more reliable and effective CSII therapy for PWD. Further studies involving human participants are recommended to validate these findings and assess the classifier’s performance in a real-world setting.
Phytochemical and Pharmacological Review of the Genus Antidesma
Authors: Nguyen-Ngoc Hieu , Le-Thi-Phuong Thao , Vu-Van Tuan , Pham-Ha-Thanh Tung , Nguyen-Huu Tung 
Published: April 2024

Background Antidesma is a large genus consisting of around 100 species, which are widely distributed in the tropics and subtropics of Asia, some species can be found in Africa, the Pacific islands, and Australia. The uses of Antidesma plants range from food (for juice, jam, and red wine production) to medicinal purposes (for treatment of indigestion, pneumonia, menstrual regulation, and osteoarthritis). Methods The review was conducted by gathering relevant literature from secondary databases, including Web of Science, Google Scholar, and PubMed, as well as specialized books and websites. Results There have been more than 140 compounds reported as chemical constituents of the genus Antidesma, which mainly belonged to alkaloid, phenolic, flavonoid, lignan, and terpenoid classes. The high content of phenolic compounds was found in A. bunius and A. thwaitesianum fruits, which also correlates with the potential anti-oxidant activities of respective plants. Besides that, the antibiotic, antifungal, and anti-inflammatory activities, as well as effects on metabolism were also investigated and reported. Conclusion The plants of the Antidesma genus have a wide range of applications in food and medicine. The published results have shown that the genus is a precious source of bioactive natural compounds, which was shown beneficial for preventive medicine. Further research is required to promote the application in the healthcare system.
COVID-19 surveillance based on consumer wearable devices
Authors: Zhang Chunbo , Sun Aijun , Liao Jiping , Zhang Cheng , Yu Kunyao , Ma Xiaoyu , Wang Guangfa 
Published: April 2024

Background Consumer wearable devices such as wristbands and smartwatches have potential application value in communicable disease surveillance. Objective We investigated the ability of wearable devices to monitor COVID-19 patients of varying severity. Methods COVID-19 patients with mobile phones supporting wearable device applications were selected from Dalian Sixth People Hospital. Physiological parameters from the wearable devices and electronic questionnaires were collected from the device wearing until 14 days post-discharge. Clinical information during hospitalization was also recorded. Based on imaging data, the patients were categorized into the milder group without pneumonia and the more severe group with pneumonia. We plotted the curves of the physiological parameters of the two groups to compare the differences and changes. Results Ninety-eight patients were included in the analysis. The mean age was 39.6 ± 10.5 years, including 45 males (45.9%). There were 24 asymptomatic patients, 10 mild patients, 60 moderate patients, and 4 severe patients. Compared with the milder group, the more severe group had higher heart rate-related parameters, while the heart rate variability (HRV) was the opposite. In the more severe group, the heart rate-related parameters showed a downward trend from 0 to 7 days after the fever resolution. Among them, the resting heart rate and sleep heart rate decreased on the 25th day after the onset and were close to the milder group 1 week after discharge. Conclusions Consumer wearable devices have the potential to monitor respiratory infections. Heart rate-related parameters obtained from these devices can be sensitive indicators of COVID-19 severity and correlate with disease evolution. Trial registration ClinicalTrials.gov NCT04459637.
Introduction: Feminist media production and beyond
Authors: Zhang Tracy Ying , Harvey Alison 
Published: April 2024

This special issue features five articles written by a group of established and emerging researchers, who carefully examined the challenges and opportunities for women's participation in media production across platforms and nations. Overall, the case studies in this special issue extend and broaden current conversations about gendered media-making practices by emphasizing an intersectional, transnational, and critical feminist perspective on identity, subjectivity, embodiment, and labour. Further, these studies highlight both structural barriers that women face in the global media industries as well as emergent resistant and interventionist tactics. Taken together, they demonstrate the value of local, situated analyses and expose the shared patriarchal repressions as well as opportunities of development for feminist media production within a transnational context.
Outer-context determinants on the implementation of school-based interventions for LGBTQ+ adolescents
Authors: Shattuck Daniel , Willging Cathleen E. , Peterson Jeffery , Ramos Mary M. 
Published: April 2024

Background Schools are critical venues for supporting LGBTQ+ youth well-being. Implementing LGBTQ-supportive practices can decrease experiences of stigmatization, discrimination, and victimization that lead to adverse mental health outcomes like anxiety, depression, and suicidality. However, schools are also subject to a wide range of outer-context pressures that may influence their priorities and implementation of LGBTQ-supportive practices. We assessed the role of emergent outer-context determinants in the context of a 5-year cluster randomized controlled trial to study the implementation of LGBTQ-supportive evidence-informed practices (EIPs) in New Mexico high schools. Method Using an iterative coding approach, we analyzed qualitative data from annual interviews with school professionals involved in EIP implementation efforts. Results The analysis yielded three categories of outer-context determinants that created challenges and opportunities for implementation: (a) social barriers related to heterocentrism, cisgenderism, and religious conservatism; (b) local, state, and national policy and political discourse; and (c) crisis events. Conclusions By exploring the implications of outer-context determinants for the uptake of LGBTQ-supportive practices, we demonstrate that these elements are dynamic—not simply reducible to barriers or facilitators—and that assessing outer-context determinants shaping implementation environments is crucial for addressing LGBTQ health equity.
Current and upcoming treatment approaches to uncommon subtypes of PTCL (EATL, MEITL, SPTCL, and HSTCL)
Authors: Marchi Enrica , Craig Jeffrey W. , Kalac Matko 
Published: April 2024

Abstract
Rare subtypes of peripheral T-cell lymphoma (PTCL) including enteropathy-associated T-cell lymphoma (EATL), monomorphic epitheliotropic intestinal T-cell lymphoma (MEITL), subcutaneous panniculitis–like T-cell lymphoma (SPTCL), and hepatosplenic T-cell lymphoma (HSTCL) are underrepresented in most registries and clinical studies. Most of the literature is obtained from small case series, single-institution retrospective studies, and subgroup analyses of the largest studies with few recent and ongoing exceptions. Although the pathogenesis and biology of these entities have yet to be fully elucidated, global efforts by the scientific community have started to shed some light on the most frequently deregulated pathways. In this review, we highlight the most pertinent clinical and pathologic features of rare subtypes of PTCL including EATL/MEITL, SPTCL, and HSTCL. We also summarize the results of recent developments identifying potential targets for novel therapeutic strategies based on molecular studies. Finally, we highlight the underrepresentation of these rare subtypes in most clinical trials, making evidence–based therapeutic decisions extremely challenging.
Gasdermin D drives focal crystalline thrombotic microangiopathy by accelerating immunothrombosis and necroinflammation
Authors: Watanabe-Kusunoki Kanako , Li Chenyu , Bandeira Honda Tâmisa Seeko , Zhao Danyang , Kusunoki Yoshihiro , Ku John , Long Hao , Klaus Martin , Han Chao , Braun Attila , Mammadova-Bach Elmina , Linkermann Andreas , Van Avondt Kristof , Richter Mathis , Soehnlein Oliver , Linder Monika I. , Klein Christoph , Steiger Stefanie , Anders Hans-Joachim 
Published: April 2024

Abstract
Thrombotic microangiopathy (TMA) is characterized by immunothrombosis and life-threatening organ failure but the precise underlying mechanism driving its pathogenesis remains elusive. In this study, we hypothesized that gasdermin D (GSDMD), a pore-forming protein that serves as the final downstream effector of the pyroptosis/interleukin-1β (IL-1β) pathway, contributes to TMA and its consequences by amplifying neutrophil maturation and subsequent necrosis. Using a murine model of focal crystalline TMA, we found that Gsdmd deficiency ameliorated immunothrombosis, acute tissue injury, and failure. Gsdmd−/− mice exhibited a decrease in mature IL-1β, as well as in neutrophil maturation, β2-integrin activation, and recruitment to TMA lesions, in which they formed reduced neutrophil extracellular traps in both arteries and interstitial tissue. The GSDMD inhibitor disulfiram dose-dependently suppressed human neutrophil pyroptosis in response to cholesterol crystals. Experiments with GSDMD–deficient, human–induced, pluripotent stem cell–derived neutrophils confirmed the involvement of GSDMD in neutrophil β2-integrin activation, maturation, and pyroptosis. Both prophylactic and therapeutic administration of disulfiram protected the mice from focal TMA, acute tissue injury, and failure. Our data identified GSDMD as a key mediator of focal crystalline TMA and its consequences, including ischemic tissue infarction and organ failure. GSDMD could potentially serve as a therapeutic target for the systemic forms of TMA.
Correlation of immune fitness with response to teclistamab in relapsed/refractory multiple myeloma in the MajesTEC-1 study
Authors: Cortes-Selva Diana , Perova Tatiana , Skerget Sheri , Vishwamitra Deeksha , Stein Sarah , Boominathan Rengasamy , Lau Onsay , Calara-Nielsen Karl , Davis Cuc , Patel Jaymala , Banerjee Arnob , Stephenson Tara , Uhlar Clarissa , Kobos Rachel , Goldberg Jenna , Pei Lixia , Trancucci Danielle , Girgis Suzette , Wang Lin Shun Xin , Wu Liviawati S. , Moreau Philippe , Usmani Saad Z. , Bahlis Nizar J. , van de Donk Niels W. C. J. , Verona Raluca I. 
Published: April 2024

AbstractTeclistamab, an off-the-shelf B-cell maturation antigen (BCMA) × CD3 bispecific antibody that mediates T-cell activation and subsequent lysis of BCMA-expressing myeloma cells, is approved for the treatment of patients with relapsed/refractory multiple myeloma (R/RMM). As a T-cell redirection therapy, clinical outcomes with teclistamab may be influenced by patient immune fitness and tumor antigen expression. We correlated tumor characteristics and baseline immune profiles with clinical response and disease burden in patients with R/RMM from the pivotal phase 1/2 MajesTEC-1 study, focusing on patients treated with 1.5 mg/kg of teclistamab (N = 165). Peripheral blood samples were collected at screening, and bone marrow samples were collected at screening and cycle 3. Better clinical outcomes to teclistamab correlated with higher baseline total T-cell counts in the periphery. In addition, responders (partial response or better) had a lower proportion of immunosuppressive regulatory T cells (Tregs), T cells expressing coinhibitory receptors (CD38, PD-1, and PD-1/TIM-3), and soluble BCMA and a T-cell profile suggestive of a more cytolytic potential, compared with nonresponders. Neither frequency of baseline bone marrow BCMA expression nor BCMA-receptor density was associated with clinical response to teclistamab. Improved progression-free survival was observed in patients with a lower frequency of T cells expressing exhaustion markers and immunosuppressive Tregs. Overall, response to teclistamab was associated with baseline immune fitness; nonresponders had immune profiles suggestive of immune suppression and T-cell dysfunction. These findings illustrate the importance of the contribution of the immune landscape to T-cell redirection therapy response. This trial was registered at www.ClinicalTrials.gov as #NCT03145181/NCT04557098.
How I treat Philadelphia chromosome–like acute lymphoblastic leukemia in children, adolescents, and young adults
Authors: Tran Thai Hoa , Tasian Sarah K. 
Published: April 2024

Abstract
Philadelphia chromosome–like acute lymphoblastic leukemia (Ph-like ALL) represents a high-risk B-lineage ALL subtype characterized by adverse clinical features and poor relapse-free survival despite risk–adapted multiagent chemotherapy regimens. The advent of next-generation sequencing has unraveled the diversity of kinase-activating genetic drivers in Ph-like ALL that are potentially amenable to personalized molecularly-targeted therapies. Based upon robust preclinical data and promising case series of clinical activity of tyrosine kinase inhibitor (TKI)–based treatment in adults and children with relevant genetic Ph-like ALL subtypes, several clinical trials have investigated the efficacy of JAK- or ABL-directed TKIs in cytokine receptor-like factor 2 (CRLF2)/JAK pathway-mutant or ABL-class Ph-like ALL, respectively. The final results of these trials are pending, and standard-of-care therapeutic approaches for patients with Ph-like ALL have yet to be defined. In this How I Treat perspective, we review recent literature to guide current evidence-based treatment recommendations via illustrative clinical vignettes of children, adolescents, and young adults with newly diagnosed or relapsed/refractory Ph-like ALL, and we further highlight open and soon-to-open trials investigating immunotherapy and TKIs specifically for this high-risk patient population.
Efficacy of CAR T-cell therapy is not impaired by previous bispecific antibody treatment in large B-cell lymphoma
Authors: Crochet Gilles , Iacoboni Gloria , Couturier Audrey , Bachy Emmanuel , Iraola-Truchuelo Josu , Gastinne Thomas , Cartron Guillaume , Fradon Tom , Lesne Bastien , Kwon Mi , Gounot Romain , Martínez-Cibrian Nuria , Castilla-Llorente Cristina , Abrisqueta Pau , Guerreiro Manuel , Sarkozy Clémentine , Aspa-Cilleruelo Jose María , Camus Vincent , Guidez Stéphanie , Chauchet Adrien , Deconinck Eric , Bouabdallah Krimo , Bosch Francesc , Barba Pere , Morschhauser Franck , Houot Roch 
Published: April 2024

Abstract
In this retrospective study, chimeric antigen receptor T cells remained effective in patients with relapsed/refractory large B-cell lymphoma after prior exposure to bispecific antibodies (BsAbs) targeting different antigens. These results are relevant to clinical practice, particularly given the increasing use of BsAbs in earlier treatment lines.