bluuebunny/crossref_metadata_2025_split huggingface dataset:
Retracted: Restoring sensitivity to oxaliplatin by a novel approach in gemcitabine‐resistant pancreatic cancer cells in vitro and in vivo
Authors: Banerjee Sanjeev , Kong Dejuan , Azmi Asfar S. , Wang Zhiwei , Ahmad Aamir , Sethi Seema , Sarkar Fazlul H. 
Published: September 2010

AbstractThis article has been retracted at the request of: Editor‐in‐Chief and Co‐author‘Restoring sensitivity to oxaliplatin by a novel approach in gemcitabine‐resistant pancreatic cancer cells in vitro and in vivo’ by Banerjee, S., Kong, D., Azmi, A. S., Wang, Z., Ahmad, A., Sethi, S. and Sarkar, F. H.The above article, published online on 16 November 2010, in Wiley Online Library (wileyonlinelibrary.com), has been retracted by agreement between the authors, the journal Editor‐in‐Chief, Professor Peter Lichter, and Wiley Periodicals, Inc. A university investigation involving the first and corresponding author determined that several figures in this paper were mislabeled, manipulated, or duplicated and relabeled while processing/compiling the final figures assembled from the original data sources. Therefore, the authors are retracting the paper in its entirety although they maintain that these issues did not affect the major conclusions. They apologize for any inconvenience this may have caused.ReferenceBanerjee, S., Kong, D., Azmi, A. S., Wang, Z., Ahmad, A., Sethi, S. and Sarkar, F. H. (2011), Restoring sensitivity to oxaliplatin by a novel approach in gemcitabine‐resistant pancreatic cancer cells in vitro and in vivo. Int. J. Cancer, 128: 1240–1250. doi: 10.1002/ijc.25658
Superconformal Electrodeposition for 3‐Dimensional Interconnects
Authors: Moffat Thomas P. , Josell Daniel 
Published: September 2010

AbstractElectrodeposition is a key fabrication process used in the state‐of‐the‐art multilevel Cu metallization of microelectronic interconnects, from transistor to circuit board length scale. Recent electrochemical surface science and feature filling studies have provided mechanistic insight into the role of additives in superconformal film growth responsible for void‐free filling of recessed surface features. These studies have shown that a physical model based on mass conservation of accelerating surfactant species during area change very effectively describes feature filling of Cu, Ag, and Au from different electrolytes. This paper presents a selective and cursory review of some relevant developments underway in our laboratory.
Two‐photon microscopy of healthy, infarcted and stem‐cell treated regenerating heart
Authors: Wallenburg Marika A. , Wu Jun , Li Ren‐Ke , Vitkin I. Alex 
Published: September 2010

AbstractTwo‐photon excitation autofluorescence (produced in myocytes) and second‐harmonic generation (produced mainly by collagen) allow label‐free visualization of these two important components of myocardium. Because of their different emission wavelengths, these two signals can be separated spectrally. Here, we examine two‐photon microscopy images of healthy, infarcted and stem‐cell treated rat hearts. We find that in infarcted heart, regions distant from the site of infarct are similar to healthy tissue in composition (mostly myocytes, very little collagen) and organization (densely packed myocytes), but infarct regions are characterized by sparse myocytes and high collagen content indicative of scar tissue formation. Stem cell treated hearts, in contrast, show regions of intertwined myocytes and collagen throughout the infarct, suggesting reduced tissue damage. Finally, these results offer interesting insights into our ongoing polarized light studies of cardiac tissue anisotropy, and reveal that both tissue composition and tissue micro‐organization are reflected in polarization‐measured linear retardance values. (© 2011 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
White‐collar crime: A due diligence issue in India
Authors: Ralph Byington J. , Ann McGee Jo 
Published: September 2010

AbstractIndia is one of the most attractive targets for mergers and acquisitions (M&As), second only to China. But it is also one of the riskiest locations for that kind of investment. One part of that risk is white‐collar crime (WCC), which continues to grow worldwide at an incredible rate. It is a plague that affects all countries‐and India is no exception.But how pervasive is WCC in India? What forms does it take? And what due diligence measures must U.S. companies take if they want to do business there? © 2010 Wiley Periodicals, Inc.
Effectiveness of a course designed to teach handoffs to medical students
Authors: Chu Eugene S. , Reid Mark , Burden Marisha , Mancini Diana , Schulz Tara , Keniston Angela , Sarcone Ellen , Albert Richard K. 
Published: September 2010

AbstractINTRODUCTION:Handoffs of patient care are increasingly common and are known to contribute to medical errors. A significant number, if not the large majority, of first‐year Internal Medicine residents have not received formal education pertaining to handoffs during medical school.AIM:To develop a program designed to teach handoffs to medical students entering their fourth year of training.SETTING:University of Colorado Denver School of Medicine.PROGRAM DESCRIPTION:Our Handoff Selective was first offered in April 2007 as part of a 2‐week Integrated Clinician's Course conducted once yearly between the third and fourth years of medical school. The Selective consisted of a didactic session in which communication theory and elements were discussed and a practicum in which students used faculty‐developed case scenarios to practice both giving and receiving handoffs.PROGRAM EVALUATION:Sixty (the maximum number of spots available) out of 150 students participated in the course, although many more students chose the course than spots available. Prior to taking the Selective, medical students' confidence in performing handoffs was poor, but it improved after the course (P < 0.001); 92% of students felt the Handoff Selective was “useful” or “extremely useful.” While both components of the course were thought to be useful to the large majority of students, the practicum portion was thought to be more useful (P < 0.001).DISCUSSION:Formal education on handoffs is well received by medical students and improves their self‐perceived understanding and performance of handoffs. Journal of Hospital Medicine 2010;5:344–348. © 2010 Society of Hospital Medicine.
Systematic review of time studies evaluating physicians in the hospital setting
Authors: Tipping Matthew D. , Forth Victoria E. , Magill David B. , Englert Kate , Williams Mark V. 
Published: September 2010

AbstractBACKGROUND:Time studies, first developed in the late 19th century, are now being used to evaluate and improve worker efficiency in the hospital setting. This is the first review of hospital time study literature of which we are aware.PURPOSE:We performed a systematic review of the literature to better understand the available time study literature describing the activities of hospital physicians.DATA SOURCES:We searched MEDLINE, EMBASE, EMBASE Classic, PsycINFO, Cochrane Library, CINAHL, and Web of Science. We also manually reviewed the reference lists of retrieved articles and consulted experts in the field to identify additional articles for review.STUDY SELECTION:We selected studies that used time‐motion or work‐sampling performed via direct observation, included physicians, medical residents, or interns in their study population, and were performed on an inpatient hospital ward.DATA EXTRACTION:We abstracted data on subject population, study site, collection tools, and percentage of time spent on key categories of activity.DATA SYNTHESIS:Our search produced 11 time‐motion and 2 work‐sampling studies that met our criteria. These studies focused primarily on academic hospitals (92%) and the activities of physicians in training (69%). Other results varied widely. A lack of methodological standardization and dissimilar activity categorizations inhibited our efforts to summarize detailed findings across studies. However, we consistently found that activities indirectly related to a patient's care took more of hospital physicians' time than direct interaction with hospitalized patients.CONCLUSIONS:Time studies, when properly performed, have a great deal to offer in helping us understand and reengineer hospital care. Journal of Hospital Medicine 2010;5:353–359. © 2010 Society of Hospital Medicine.
The impact of fragmentation of hospitalist care on length of stay
Authors: Epstein Kenneth , Juarez Esther , Epstein Anne , Loya Kathy , Singer Adam 
Published: September 2010

AbstractBACKGROUND:Different hospitalist staffing models provide different levels of inpatient continuity of care, which may impact length of stay (LOS).OBJECTIVE:To determine if fragmentation of care (FOC) by hospitalist physicians is associated with LOS.DESIGN:Concurrent control study.SETTING:Hospitalist practices managed by IPC The Hospitalist Company.PATIENTS:A total of 10,977 patients admitted for diagnosis‐related group (DRG) of 89 pneumonia with complications or comorbidities (PNA) or a DRG of 127 heart failure and shock (HF) between December 2006 and November 2007.MEASUREMENTS:FOC was defined as the percentage of care given by hospitalists other than the hospitalist who saw the patient the majority of the stay. Negative binomial regression was performed on DRG 89 and DRG 127 patients with LOS as the dependent variable. We adjusted for gender, age, severity of illness (SOI) scores, risk of mortality (ROM) scores, and number of secondary diagnoses, and admission day of the week.RESULTS:A 10% increase in fragmentation was associated with an increase of 0.39 days (P < 0.0001) in the LOS for pneumonia, and an increase of 0.30 days (P < 0.0001) in LOS for heart failure.CONCLUSIONS:As FOC increased for pneumonia and heart failure, the LOS increased significantly. Methods to reduce fragmentation should be explored, while more research is needed to identify the source of the relationship between FOC and LOS. Journal of Hospital Medicine 2010;5:335–338. © 2010 Society of Hospital Medicine.
Determination of the cultivar and aging of Sicilian olive oils using HPLC‐MS and linear discriminant analysis
Authors: Agozzino Pasquale , Avellone Giuseppe , Bongiorno David , Ceraulo Leopoldo , Indelicato Serena , Indelicato Sergio , Vèkey Kàroly 
Published: September 2010

AbstractA large number of certified samples (84) of Sicilian olive oils arising from the eight cultivars most represented in Sicily (Biancolilla, Cerasuola, Moresca, Nocellara del Belice, Nocellara Etnea, Oglialora Messinese, Brandofino and Tonda Iblea) have been collected and analyzed by HPLC/MS using an atmospheric pressure chemical ionization (APCI) source. The sample preparation is very simple; in fact, the oil samples are diluted without any chemical derivatization. A following statistical data treatment by general discriminant analysis (GDA) allows the determination of the olive oil cultivar. Furthermore, changes in the composition of glyceridic components of the olive oils lead to easy discrimination between fresh oils and 1‐year‐old samples. Copyright © 2010 John Wiley & Sons, Ltd.
Human papillomavirus and WHO type I nasopharyngeal carcinoma
Authors: Lo Emily J. , Bell Diana , Woo Jason S. , Li Guojun , Hanna Ehab Y. , El‐Naggar Adel K. , Sturgis Erich M. 
Published: September 2010

AbstractObjectives:Nasopharyngeal carcinoma (NPC) is a rare cancer in the United States. An association between NPC and Epstein‐Barr virus (EBV) is well‐established for World Health Organization (WHO) types II and III (WHO‐II/III) NPC but less well‐established for WHO type I (WHO‐I) NPC. Given the rise in oropharyngeal tumors positive for high‐risk human papillomavirus (HPV) and the unique biology of WHO‐I NPC, we examined the relationship between HPV and WHO‐I NPC.Study Design:Retrospective case‐comparison study.Methods:A search of a large multidisciplinary cancer center tumor registry identified 183 patients seen from January 1999 to December 2008 with incident NPC and no prior cancer. Available paraffin‐embedded tumor specimens (N = 30) were analyzed for oncogenic HPV status by in situ hybridization (ISH) and polymerase chain reaction (PCR) for HPV‐16 and HPV‐18; EBV status by ISH; and p16 expression by immunohistochemistry. Demographic parameters, including race and smoking, were obtained from the medical records.Results:Among the 18 WHO‐I NPC patients, 66% (N = 12) were smokers and 17% (N = 3) Asian; among the 165 WHO‐II/III NPC patients, 44% (N = 73) were smokers and 24% (N = 39) Asian. Eight WHO‐I NPC patients had available paraffin blocks; five of six were HPV‐16‐positive by PCR and four of eight were HPV‐positive by ISH; only two of eight (25%) were EBV‐positive. Twenty‐two WHO‐II/III NPC patients had available paraffin blocks; only 1 was HPV‐positive by ISH, and 13 of 22 (60%) were EBV‐positive.Conclusions:These results suggest that WHO‐I NPC is associated with oncogenic HPV, although larger studies are needed to verify these findings. Laryngoscope, 2010
Levodopa and subthalamic deep brain stimulation responses are not congruent
Authors: Zaidel Adam , Bergman Hagai , Ritov Ya'acov , MD Zvi Israel 
Published: September 2010

AbstractThere is a consensus that in Parkinson's disease, the extent of preoperative levodopa responsiveness predicts the efficacy of subthalamic nucleus deep brain stimulation (STN DBS). However, this may be the result of statistical methods and primary assumptions. We were able to reproduce previously published correlation results on our data (N = 49 patients). Yet, these same results were demonstrated even after random shuffling of our data. Notably, we did not observe a correlation between STN DBS efficacy and preoperative levodopa responsiveness when using their respective baselines and fractional scores of motor improvement. Furthermore, postoperative responses were not limited by preoperative scores, with tremor demonstrating the greatest discrepancy. We conclude that preoperative levodopa responsiveness does not predict or limit the outcome of STN DBS. These results imply different therapeutic mechanisms for levodopa and STN DBS and therefore question the validity of using substantial preoperative levodopa responsiveness as a selection criterion for STN DBS. © 2010 Movement Disorder Society
A capacitively coupled temperature‐jump arrangement for high‐resolution biomolecular NMR
Authors: Gal Maayan , Zibzener Koby , Frydman Lucio 
Published: September 2010

AbstractA simple design for performing rapid temperature jumps within a high‐resolution nuclear magnetic resonance (NMR) setting is presented and exemplified. The design is based on mounting, around a conventional NMR glass tube, an inductive radiofrequency (RF) irradiation coil that is suitably tuned by a resonant circuit and is driven by one of the NMR's console high‐power RF amplifiers. The electric fields generated by this coil's thin metal strips can lead to a fast and efficient heating of the sample, amounting to temperature jumps of ≈ 20 °C in well within a second—particularly in the presence of lossy dielectric media like those provided by physiological buffers. Moreover, when wound around a 4‐mm NMR tube, the resulting device fits a conventional 5‐mm inverse probe and is wholly compatible with the field homogeneities and sensitivities expected for high‐resolution biomolecular NMR conditions. The performance characteristics of this new system were tested using saline solutions, as well as on a lyotropic liquid crystal capable of undergoing nematic → isotropic transitions in the neighborhood of ambient temperature. These settings were then incorporated into the performance of a new kind of single‐scan 2D NMR spectroscopy acquisition, correlating the anisotropic and isotropic patterns elicited by solutes dissolved in such liquid‐crystalline systems, before and after a sudden temperature jump occurring during an intervening mixing period. Copyright © 2010 John Wiley & Sons, Ltd.
Interpretation of vicinal proton–proton coupling constants of heteroaromatic molecules in terms of topological electron density descriptors
Authors: Sánchez‐Mendoza Ernesto , Hernández‐Trujillo Jesús 
Published: September 2010

AbstractThe indirect vicinal proton–proton coupling constants for pyrrole, furan, thiophene and 15 related heteroaromatic compounds were calculated using the Khon–Sham approximation. An analysis of the four Ramsey contributions to the coupling constants was carried out showing that the Fermi contact term is always positive and dominant, although the remaining contributions have a nonnegligible net negative contribution. The trends observed for the proton–proton coupling constants were rationalized in terms of the properties of the electron density. It was found that electron delocalization between the corresponding hydrogen atoms plays a major role on the observed behavior with the charges of the carbon atoms bonded to them and the accompanying geometric variations being also of importance in the coupling mechanism. Copyright © 2010 John Wiley & Sons, Ltd.
Dyskerin and cancer: more than telomerase. The defect in mRNA translation helps in explaining how a proliferative defect leads to cancer
Authors: Montanaro Lorenzo 
Published: September 2010

AbstractPoint mutations in the DKC1 gene that encodes dyskerin cause the rare inherited syndrome called X‐linked dyskeratosis congenita, characterized by a failure of proliferating tissues and increased susceptibility to cancer. Dyskerin is a nucleolar protein with different functions, all fundamental to basic cellular events such as protein expression, growth, and proliferation. The two best‐characterized dyskerin activities are the stabilization of the telomerase RNA component, allowing the proper function telomerase enzymatic complex, and the modification of specific uridine residues of ribosomal RNA by converting them to pseudouridine, thus allowing proper ribosome processing and function. In light of the recent findings, this review focuses on the molecular pathogenesis of dyskeratosis congenita, discussing how a defect in ribosomal function might impact on the translation of a subset of mRNAs encoding for tumour suppressors, thus providing an explanation for the apparent paradox of dyskeratosis congenita in which reduced cell proliferation is associated with cancer susceptibility. In addition, the current evidence pointing to a role played by dyskerin in tumours in the general population is also discussed. Copyright © 2010 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
Thermochemistry, bond energies and internal rotor barriers of methyl sulfinic acid, methyl sulfinic acid ester and their radicals
Authors: Gunturu Anjani , Asatryan Rubik , Bozzelli Joseph W. 
Published: September 2010

AbstractSulfur–Oxygen containing hydrocarbons are formed in oxidation of sulfides and thiols in the atmosphere, on aerosols and in combustion processes. Understanding their thermochemical properties is important to evaluate their formation and transformation paths. Structures, thermochemical properties, bond energies, and internal rotor potentials of methyl sulfinic acid CH3S(O)OH, its methyl ester CH3S(O)OCH3 and radicals corresponding to loss of a hydrogen atom have been studied. Gas phase standard enthalpies of formation and bond energies were calculated using B3LYP/6‐311G (2d, p) individual and CBS‐QB3 composite methods employing work reactions to further improve accuracy of the ${\Delta} _{{\bf f}} H_{{\bf 298}}^{{\bf o}} $. Molecular structures, vibration frequencies, and internal rotor potentials were calculated. Enthalpies of the parent molecules CH3S(O)OH and CH3S(O)OCH3 are evaluated as −77.4 and −72.7 kcal mol−1 at the CBSQB3 level; Enthalpies of radicals C•H2S(O)OH, CH3S•(O)2, C•H2S(O)OCH3 and CH3S(O)OC•H2 (CBS‐QB3) are −25.7, −52.3, −22.8, and −26.8 kcal mol−1, respectively. The CH3C(O)O—H bond dissociation energy is of 77.1 kcal mol−1. Two of the intermediate radicals are unstable and rapidly dissociate. The CH3S(O)O. radical obtained from the parent CH3S(O)OH dissociates into methyl radical (${\bf CH}_{{\bf 3}}^{{\bf .}} $) plus SO2 with endothermicity (ΔHrxn) of only 16.2 kcal mol−1. The CH3S(O)OC•H2 radical dissociates into CH3S•=O and CH2=O with little or no barrier and an exothermicity of −19.9 kcal mol−1. DFT and the Complete Basis Set‐QB3 enthalpy values are in close agreement; this accord is attributed to use of isodesmic work reactions for the analysis and suggests this combination of B3LYP/work reaction approach is acceptable for larger molecules. Copyright © 2010 John Wiley & Sons, Ltd.
Noncovalent functionalization of multiwalled carbon nanotubes using graft copolymer with naphthalene and its application as a reinforcing filler for poly(styrene‐co‐acrylonitrile)
Authors: Kim Kyung Tae , Jo Won Ho 
Published: September 2010

AbstractA new compatibilizer, poly(vinyl benzyloxy ethyl naphthalene)‐graft‐poly(methyl methacrylate), for poly(styrene‐co‐acrylonirile) (SAN)/multi‐walled carbon nanotubes (MWCNTs) composites was synthesized. It has been identified that naphthalene unit in backbone of compatibilizer interacts with MWCNTs via ππ interaction and that the PMMA graft of the compatibilizer is miscible with the SAN matrix. When a small amount of compatibilizer was added to SAN/MWCNT composites, MWCNTs were more homogeneously dispersed in SAN matrix than the case without compatibilizer, indicating that the compatibilizer improves the compatibility between SAN and MWCNTs. As a consequence, mechanical and electrical properties of the composites with compatibilizer were largely improved as compared with those of composites without compatibilizer. © 2010 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 48: 4184–4191, 2010
Electrochemical synthesis of poly(3,4‐ethylenedioxythiophene) nanotube arrays using ZnO templates
Authors: Döbbelin M. , Tena‐Zaera R. , Carrasco P. M. , Sarasua J.‐R. , Cabañero G. , Mecerreyes D. 
Published: September 2010

AbstractA new method toward vertically oriented poly(3,4‐ethylenedioxythiophene) (PEDOT) nanotube arrays on transparent conductive oxide substrates is presented. The approach is based on the use of ZnO nanowire arrays as templates for the electropolymerization of PEDOT. Robust arrays of vertically oriented PEDOT nanotubes with different lengths and wall thicknesses were obtained by modifying the ZnO nanowire length and charge density passed during the electropolymerization, respectively. Furthermore, PEDOT nanotubes with different morphologies (top‐closed and mushroom‐like) were successfully designed by varying the PEDOT electropolymerization kinetics or monomer diffusion or both. © 2010 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem, 2010