bluuebunny/crossref_metadata_2025_split huggingface dataset:
Integrative analysis of metabolome and transcriptome reveals regulatory mechanisms of flavonoid biosynthesis in soybean under salt stress
Authors: Wang Yubin , Liu Wei , Li Wei , Wang Caijie , Dai Haiying , Xu Ran , Zhang Yanwei , Zhang Lifeng 
Published: June 2024

IntroductionSalt stress is a major environmental factor that constrains soybean growth, development, and productivity. Flavonoids are key secondary metabolites that play a crucial role in enhancing plant resistance to both biotic and abiotic stress. However, a comprehensive understanding of the regulatory mechanisms underlying flavonoid biosynthesis under salt stress in soybean is lacking.MethodsIn this study, an integrative analysis of soybean metabolome and transcriptome was conducted using two soybean lines, FQ03 (salt-sensitive, SS) and FQ07 (salt-tolerant, ST).ResultsA total of 650 significantly changed metabolites were identified in SS and ST after salt stress treatment. Among them, 151 flavonoids were categorized into nine classes, with flavones and flavonols being the predominant flavonoid types in soybean. Heatmap analysis showed higher contents of most flavonoid metabolites in ST than in SS under salt stress, and the total flavonoid content in ST was significantly higher than that in SS. In addition, transcriptome analysis revealed a higher number of differentially expressed genes (DEGs) in ST than in SS under salt stress. KEGG enrichment analysis revealed that DEGs were mainly enriched in pathways related to phenylpropanoid biosynthesis, isoflavonoid biosynthesis, flavonoid biosynthesis, as well as flavone and flavonol biosynthesis. Notably, 55 DEGs that were mapped to the flavonoid biosynthetic pathway were identified, with most showing higher expression levels in ST than in SS. Weighted gene correlation network analysis identified eight structural genes and six transcription factor genes as key regulators of flavonoid biosynthesis within the blue module. Furthermore, qRT-PCR results confirmed the accuracy of the transcriptomic data and reliability of the identified candidate genes.DiscussionThis study provides insights into the regulatory mechanisms underlying salt stress responses in soybean and highlights hub genes as potential targets for developing salt-tolerant soybean varieties.
Early cognitive assessment in premature infants: the discriminatory value of eye-tracking vs. Bayley Scales
Authors: Kaltsa Maria , Babacheva Evgenia , Fotiadou Georgia , Goutsiou Evanthia , Kantziou Katerina , Nicolaidis Katerina , Soubasi Vasiliki 
Published: June 2024

IntroductionThe testing of visuocognitive development in preterm infants shows strong interactions between perinatal characteristics and cognition, learning and overall neurodevelopment evolution. The assessment of anticipatory gaze data of object-location bindings via eye-tracking can predict the neurodevelopment of preterm infants at the age of 3 years; little is known, however, about the early cognitive function and its assessment methods during the first year of life.MethodsThe current study presents data from a novel assessment tool, a Delayed Match Retrieval (DMR) paradigm via eye-tracking was used to measure visual working memory (VWM) and attention skills. The eye-tracking task that was designed to measure infants’ ability to actively localize objects and to make online predictions of object-location bindings. 63 infants participated in the study, 39 preterm infants and 24 healthy full term infants – at a corrected age of 8–9 months for premature infants and similar chronological age for full term infants. Infants were also administered the Bayley Scales of Infant and Toddler Development.ResultsThe analysis of the Bayley scores showed no significant difference between the two groups while the eye-tracking data showed a significant group effect on all measurements. Moreover, preterm infants’ VWM performance was significantly lower than full term’s. Birth weight affected the gaze time on all Areas Of Interest (AOIs), overall VWM performance and the scores at the Cognitive Bayley subscale. Furthermore, preterm infants with fetal growth restriction (FGR) showed significant performance effects in the eye-tracking measurements but not on their Bayley scores verifying the high discriminatory value of the eye gaze data.ConclusionVisual working memory and attention as measured via eye-tracking is a non-intrusive, painless, short duration procedure (approx. 4-min) was found to be a significant tool for identifying prematurity and FGR effects on the development of cognition during the first year of life. Bayley Scales alone may not pick up these deficits. Identifying tools for early neurodevelopmental assessments and cognitive function is important in order to enable earlier support and intervention in the vulnerable group of premature infants, given the associations between foundational executive functional skills and later cognitive and academic ability.
Influence of anxious attachment on the relationship between primary emotions and substance-related addictive behaviors
Authors: Fuchshuber Jürgen , Andres Deborah , Prandstätter Theresa , Roithmeier Lisa , Schmautz Beate , Schwerdtfeger Andreas , Unterrainer Human-Friedrich 
Published: June 2024

ObjectivesTo date there is no universally accepted model that describes the development of substance related addictive behavior. In order to address this gap, the study sought to examine whether the association between primary emotions and the inclination toward addictive behavior is mediated by an anxious attachment style.MethodsThe total sample consisted of 900 German speaking non-clinical adults (age: M = 27; SD = 9.60; 71.6% female). Structural Equation Modeling (SEM) was applied to examine the connection between the primary emotions (SADNESS and ANGER), and the latent variables attachment anxiety and symptoms of addictive behavior.ResultsSubstance use symptomatology was correlated with higher attachment anxiety (r = 0.15), SADNESS (r = 0.15), and ANGER (r = 0.11). The effect of SADNESS on addictive behavior is mediated by attachment anxiety (p &lt; 0.01) whereas ANGER had a direct effect on addictive behavior (p &lt; 0.01). The final SEM explains 4% of the variance of addictive behaviors and 22% of attachment anxiety.ConclusionOur findings suggest that both SADNESS and ANGER, along with attachment anxiety, are dispositions that contribute to the risk of engaging in addictive behavior. However, while ANGER directly influences addictive behavior, SADNESS acts through its impact on attachment anxiety.
Contextual emotion detection in images using deep learning
Authors: Limami Fatiha , Hdioud Boutaina , Oulad Haj Thami Rachid 
Published: June 2024

IntroductionComputerized sentiment detection, based on artificial intelligence and computer vision, has become essential in recent years. Thanks to developments in deep neural networks, this technology can now account for environmental, social, and cultural factors, as well as facial expressions. We aim to create more empathetic systems for various purposes, from medicine to interpreting emotional interactions on social media.MethodsTo develop this technology, we combined authentic images from various databases, including EMOTIC (ADE20K, MSCOCO), EMODB_SMALL, and FRAMESDB, to train our models. We developed two sophisticated algorithms based on deep learning techniques, DCNN and VGG19. By optimizing the hyperparameters of our models, we analyze context and body language to improve our understanding of human emotions in images. We merge the 26 discrete emotional categories with the three continuous emotional dimensions to identify emotions in context. The proposed pipeline is completed by fusing our models.ResultsWe adjusted the parameters to outperform previous methods in capturing various emotions in different contexts. Our study showed that the Sentiment_recognition_model and VGG19_contexte increased mAP by 42.81% and 44.12%, respectively, surpassing the results of previous studies.DiscussionThis groundbreaking research could significantly improve contextual emotion recognition in images. The implications of these promising results are far-reaching, extending to diverse fields such as social robotics, affective computing, human-machine interaction, and human-robot communication.
The rapidly changing field of predictive biomarkers of non-small cell lung cancer
Authors: Tóth László József , Mokánszki Attila , Méhes Gábor 
Published: June 2024

Lung cancer is a leading cause of cancer-related death worldwide in both men and women, however mortality in the US and EU are recently declining in parallel with the gradual cut of smoking prevalence. Consequently, the relative frequency of adenocarcinoma increased while that of squamous and small cell carcinomas declined. During the last two decades a plethora of targeted drug therapies have appeared for the treatment of metastasizing non-small cell lung carcinomas (NSCLC). Personalized oncology aims to precisely match patients to treatments with the highest potential of success. Extensive research is done to introduce biomarkers which can predict the effectiveness of a specific targeted therapeutic approach. The EGFR signaling pathway includes several sufficient targets for the treatment of human cancers including NSCLC. Lung adenocarcinoma may harbor both activating and resistance mutations of the EGFR gene, and further, mutations of KRAS and BRAF oncogenes. Less frequent but targetable genetic alterations include ALK, ROS1, RET gene rearrangements, and various alterations of MET proto-oncogene. In addition, the importance of anti-tumor immunity and of tumor microenvironment has become evident recently. Accumulation of mutations generally trigger tumor specific immune defense, but immune protection may be upregulated as an aggressive feature. The blockade of immune checkpoints results in potential reactivation of tumor cell killing and induces significant tumor regression in various tumor types, such as lung carcinoma. Therapeutic responses to anti PD1-PD-L1 treatment may correlate with the expression of PD-L1 by tumor cells. Due to the wide range of diagnostic and predictive features in lung cancer a plenty of tests are required from a single small biopsy or cytology specimen, which is challenged by major issues of sample quantity and quality. Thus, the efficacy of biomarker testing should be warranted by standardized policy and optimal material usage. In this review we aim to discuss major targeted therapy-related biomarkers in NSCLC and testing possibilities comprehensively.
Treatment specifics for sialadenosis of the parotid glands in patients undergoing eradication therapy
Authors: Konovalova T. A. , Kozlova M. V. , Chorbinskaya S. A. , Manuilov B. M. , Aleshkin V. A. 
Published: June 2024

Relevance. Treating patients with comorbid pathologies of the parotid salivary glands (PSGs) and the gastrointestinal tract presents a significant clinical challenge. Sialadenosis commonly develops in acid-dependent diseases associated with H. pylori (HP) infection, often manifesting as complaints of dry mouth. This condition leads to a reduction in local immunological defense due to decreased levels of sIgA, which is predominantly sourced from parotid secretion. Gastroenterologists typically prescribe eradication therapy that includes a proton pump inhibitor (PPI), which, according to its pharmacodynamic properties, can cause drug-induced xerostomia.Material and methods. A total of 115 individuals with sialadenosis of the PSGs and HP infection, confirmed by a positive urease rapid test in parotid secretion, aged 46.42 ± 6.21 years, were examined. The participants were randomly assigned into groups based on the prescription of absorbable gingival collagen membranes and the dose of a complex immunoglobulin preparation (CIP). The groups were as follows: Group I – 35 individuals without local therapy; Group II – 40 patients receiving 30 mg CIP; Group III – 40 patients receiving 60 mg CIP. Additionally, a control group consisting of 20 healthy individuals aged 44.46 ± 4.12 years was included. Gastroenterologists prescribed a standard triple eradication regimen, which included a proton pump inhibitor (PPI) at double dosage, 1000 mg amoxicillin, and 500 mg clarithromycin, taken twice daily for 14 days. All participants underwent comprehensive dental examinations at various stages: diagnosis, day 14 of eradication, and days 21 and 28 of observation.Results. A significant increase in PSG sialometry and sIgA levels in parotid secretion was observed in patients using absorbable gingival collagen membranes and CIP in addition to standard treatment. At a CIP dose of 60 mg, a negative urease rapid test was determined in parotid secretion by day 14, while at 30 mg, this occurred by day 21, confirming the effectiveness of the therapy.Conclusion. Treating patients with PSG sialadenosis undergoing eradication therapy requires a comprehensive interdisciplinary approach. It is necessary to include absorbable gingival collagen membranes and CIP at a dose of 60 mg twice daily for 21 days.
Determinan Penggunanan Digital Banking Pada Generasi Y Dan Generasi Z Muslim Di Kota Banda Aceh
Authors: Muliza Muliza 
Published: June 2024

The development of information technology has given a new face to the financial and banking industry, such as the presence of digital banks. Implementation of Aceh Qanun Number 11 of 2018 concerning Sharia Financial Institutions (LKS) also does not become an obstacle for digital banking, because digital banks do not require physical services to carry out their activities. Currently, more than 90% of digital banks in Indonesia use conventional systems. The movement in the development of digital banks has shown quite significant growth in Indonesia, especially during the Covid-19 pandemic when demands for physical meetings were implemented. This research aims to look at the determinants of digital bank use among generations Y and Z Muslims in Banda Aceh City by analyzing the relationship between eight independent variables, namely economic value, ease of use, social influence, company reputation, promotion, features, curiosity and appreciation. The population in this research is all generations Y and Z Muslims in Banda Aceh City who have used digital banking services for at least 4 months. The sample used was 100 people using a purposive sampling technique. Data was collected by distributing questionnaires using a Likert scale instrument, which was then analyzed using multiple linear regression analysis techniques. The research results show that all variables except the sales promotion and curiosity variable have a significant effect on the intention to use digital banking in the city of Banda Aceh.
Keywords : Digital Banking, Generation Y and Generation Z
Christian Sacred Geography of the Kalamun Plateau in the Middle Ages and Modern Era
Authors: Панченко К.А. 
Published: June 2024

В статье рассматриваются пути эволюции христианской сакральной географии на примере плато Каламун в центральной Сирии (селения Сайдная, Маалула, Кара и др.), до недавнего времени – области компактного расселения христиан и бытования новоарамейского языка. По данным археологии и искусствоведения, древнейшая фаза выстраивания христианского сакрального ландшафта в регионе относится к ранневизантийской эпохе (IV–VI вв.). После полосы «темных веков» (VII–X вв.) появляется целый ряд письменных источников, позволяющих реконструировать систему св. мест региона, начиная с XI в. Большая часть этих текстов связана с культом Сайднайской иконы Богоматери, выступавшей в Высокое Средневековье святыней общехристианского масштаба. С XV в. уровень почитания Сайднайской иконы снижается до регионального, а с XVII в. заметно сокращение христианского населения плато Каламун вследствие миграций и исламизации, вслед за чем деградирует система местной сакральной географии. Различные фазы этого упадка отражены путешественниками кон. XVII–XIX вв.
The article explores the evolution of Christian sacred geography, as exemplified by the Kalamun Plateau in central Syria (including the villages of Sednayah, Maalula, Qara, etc.), which until recently was an area densely populated by Christians, where the New Aramaic language was spoken. Insights from archaeology and art history indicate that the earliest phase of Christian sacred landscape's emergence in the region dates back to the early Byzantine period (4th—6th centuries). Following a period known as the «Dark Ages» (7th—10th centuries), numerous written sources emerged that facilitate the reconstruction of the region's sacred site system, starting from the 11th century. Most of these sources are associated with the veneration of the Icon of Our Lady of Sednayah, which was considered a pan-Christian relic during the High Middle Ages. From the 15th century onward, worship of the Sednayah Icon shrank to just the regional level, and in the 17th century, the Christian population of the Kalamun Plateau began to decline noticeably due to migration and the spread of Islam; the local sacred geography system deteriorated as a result. The various stages of this decline are documented by travellers in the late 17th through 19th centuries.
ТВОРЧА ДІЯЛЬНІСТЬ НАЦІОНАЛЬНОЇ ЗАСЛУЖЕНОЇ КАПЕЛИ БАНДУРИСТІВ УКРАЇНИ ІМЕНІ Г.І. МАЙБОРОДИ В СУСПІЛЬНО-ІСТОРИЧНИХ УМОВАХ 2013-2024 РОКІВ
Authors: Пронь Софія 
Published: June 2024

Досліджується творча діяльність Національної заслуженої капели бандуристів України ім. Г. Майбороди в умовах суспільно-історичних подій 2013-2024 рр. Виокремлено основні етапи становлення капели в контексті національно-визвольних змагань в Україні; охарактеризовано концертно-гастрольну діяльність капели під орудою головного диригента, народного артиста України Юрія Курача (2013-2024 рр.) та мистецький внесок керівників-диригентів, композиторів-аранжувальників у формуванні виконавського стилю колективу. Акцентується на культурно-мистецькій діяльності капели, пов’язаній з суспільно-історичними подіями 2013-2024 рр. Назвати важливі ансамблеві форми концертно-виконавської діяльності. Систематизовано мистецькі програми, репрезентовані різноманітним жанрово-стильовим репертуаром; простежено співпрацю капели бандуристів з оперними й камерними співаками, композиторами, майстрами художнього слова; проаналізовано приклади спільних проєктів із громадськими організаціями, музичними колективами, творчими спілками. Доведено, що Національна заслужена капела бандуристів ім. Г. Майбороди популяризує, зберігає національно-культурну спадщину, патріотичні цінності, представляючи бандурне виконавство не лише в Україні, але й за її межами.
ТЕНДЕНЦІЇ СИНТЕЗУ РЕГІОНАЛЬНИХ ТЕКСТИЛЬНИХ ТРАДИЦІЙ ТА НОВАЦІЙ У ТВОРЧОСТІ МАРТИ ТА ІВАННИ ТОКАР
Authors: Локшук Ірина 
Published: June 2024

Стаття присвячена розвитку текстильного мистецтва на Рівненщині. Розглядаються творчий доробок М. Токар, яка зосереджувала свою діяльність на теренах Львова, Рівного, а також мистецька діяльність її доньки – І. Токар. Текстильна спадщина останньої зосереджена в руслі виконання гобелена, батика, текстильної пластики тощо. Виявляється мистецький доробок М. Токар, творчість якої тісно переплітається зі створенням сценічних костюмів для музичних українських колективів. При формуванні сценічного костюму художниця вивчала етнографічну базу та традиції народного вбрання регіонів Полісся та Волині. Серед іншого, були виконані костюми для студентського фольклорно-етнографічного ансамблю «Джерело» (1989-1990 рр.) та костюми для студентського оркестру народної музики «Мереживо» РДГУ (1998-1999 рр.).
Вивчається творчість І. Токар, яка виробила власну манеру передачі ідеї, образу, композиції, застосування колористичних відтінків у текстильному мистецтві. Наслідуючи почерк своєї матері, мисткиня сформувалася у львівському середовищі, а нині її текстильна творчість збагатилася регіональними поліськими та волинськими акцентами. Це помітно у використанні художницею природних матеріалів (лляних ниток) під час ткання гобеленів, у наданні переваги насиченим та вибіленим відтінкам сірого кольору, червоного і вкраплення чорного кольорів, притаманних для традиційних поліських тканин. Так, у 1990-х рр. вона відтворила спроектовані М. Токар комплекти вбрання для ансамблю скрипалів під керівництвом завідувача кафедри народних інструментів РДГУ О. Степанова.Простежується синтез регіональних текстильних традицій та новацій у творчості М. Токар та І. Токар. Традиція через елементи культури, які передаються від покоління до покоління, і зберігаються протягом тривалого часу та слугують регулятором суспільних стосунків, є основою міцно збереженої регіональної ткацької звичаєвості на Поліссі.
The use of hydrogen peroxide as a chemical in drinking water supply
Authors: Селюков А.В. , Байкова И.С. 
Published: June 2024

Рассмотрено применение перекиси водорода для очистки природных подземных вод от железа и сероводорода в контексте рекомендаций новой редакции СП 31.13330.2021 «СНиП 2.04.02-84*. Водоснабжение. Наружные сети и сооружения». Приводится краткий обзор имеющихся данных о химических закономерностях процессов окисления железа и сероводорода и факторах, оказывающих влияние на их протекание. На основании данных натурных испытаний, а также опыта длительной эксплуатации водопроводных очистных сооружений в городах Новом Уренгое и Ноябрьске предложена формула для расчета дозы перекиси водорода при очистке природных подземных вод от железа. Даны рекомендации по оценке потребности в этом окислителе при очистке воды от сероводорода. Такая технология обеспечивает получение питьевой воды нормативного качества. Сделан вывод о перспективности применения перекиси водорода в качестве реагента питьевого водоснабжения ввиду ее работоспособности при низких значениях рН, щелочности, температуры воды, независимости процесса от содержания кремния, углекислоты, кислорода, а также невысокой стоимости, низкой энергоемкости и трудоемкости обслуживания необходимого оборудования. Также рекомендуется включить предложенную формулу для расчета дозы перекиси водорода в рекомендации СП 31.13330.2021 по обезжелезиванию подземных вод.
The use of hydrogen peroxide for the removal of iron and hydrogen sulfide from natural groundwater is considered in the context of the recommendations of the new edition of CP 31.13330.2021 «SNiP 2.04.02-84*. Water supply. External networks and structures». A brief overview of the available data on the chemical regularities of the iron and hydrogen sulfide oxidation processes, and the factors affecting their behavior is provided. Based on data of the field tests, as well as on the experience of long-term operation of the water treatment facilities in the cities of Novy Urengoy and Noyabrsk, a formula is proposed for calculating the dose of hydrogen peroxide while removing iron from natural groundwater. Recommendations are given for estimating the demand for this oxidizer while removing hydrogen sulfide from natural groundwater. This technology provides for the drinking water of standard quality. The conclusion is drawn that the use of hydrogen peroxide as a chemical is promising for drinking water supply owing to its working efficiency at low pH values, alkalinity, water temperature; process independence from the silicon, carbon dioxide, oxygen concentrations, as well as low cost, low energy intensity and serviceability of the required equipment. It is also recommended to include the proposed formula for calculating the dose of hydrogen peroxide in the recommendations of CP 31.13330.2021 on groundwater de-ironing.