bluuebunny/crossref_metadata_2025_split huggingface dataset:
The role of anoctamin 1 in liver disease
Authors: Li Xin , Wang Yongfeng , Zhang Li , Yao Shun , Liu Qian , Jin Hai , Tuo Biguang 
Published: April 2024

AbstractLiver diseases include all types of viral hepatitis, alcoholic liver disease (ALD), nonalcoholic fatty liver disease (NAFLD), cirrhosis, liver failure (LF) and hepatocellular carcinoma (HCC). Liver disease is now one of the leading causes of disease and death worldwide, which compels us to better understand the mechanisms involved in the development of liver diseases. Anoctamin 1 (ANO1), a calcium‐activated chloride channel (CaCC), plays an important role in epithelial cell secretion, proliferation and migration. ANO1 plays a key role in transcriptional regulation as well as in many signalling pathways. It is involved in the genesis, development, progression and/or metastasis of several tumours and other diseases including liver diseases. This paper reviews the role and molecular mechanisms of ANO1 in the development of various liver diseases, aiming to provide a reference for further research on the role of ANO1 in liver diseases and to contribute to the improvement of therapeutic strategies for liver diseases by regulating ANO1.
Glutathione peroxidase 4 restrains temporomandibular joint osteoarthritis progression by inhibiting ferroptosis
Authors: Pang Chunyan , Zhang Hongmei , Liu Yi , Tang Na , Tian Kun , Mu Yandong , Li Xue , Xiao Li 
Published: April 2024

AbstractThere are few effective therapeutic strategies for temporomandibular joint osteoarthritis (TMJOA) due to the unclear pathology and mechanisms. We aimed to confirm the roles of GPX4 and ferroptosis in TMJOA progression. ELISA assay was hired to evaluate concentrations of ferroptosis‐related markers. The qRT‐PCR assay was hired to assess gene mRNA level. Western blot assay and immunohistochemistry were hired to verify the protein level. CCK‐8 assay was hired to detect cell viability. Human fibroblast‐like synoviocytes (FLSs) were cultured to confirm the effects of GPX4 and indicated inhibitors, and further verified the effects of GPX4 and ferroptosis inhibitors in TMJOA model rats. Markers of ferroptosis including 8‐hidroxy‐2‐deoxyguanosine (8‐OHdG) and iron were notably increased in TMJOA tissues and primary OA‐FLSs. However, the activity of the antioxidant system including the glutathione peroxidase activity, glutathione (GSH) contents, and glutathione/oxidized glutathione (GSH/GSSG) ratio was notably inhibited in TMJOA tissues, and the primary OA‐FLSs. Furthermore, the glutathione peroxidase 4 (GPX4) expression was down‐regulated in TMJOA tissues and primary OA‐FLSs. Animal and cell experiments have shown that ferroptosis inhibitors notably inhibited ferroptosis and promoted HLS survival as well as up‐regulated GPX4 expression. Also, GPX4 knockdown promoted ferroptosis and GPX4 overexpression inhibited ferroptosis. GPX4 also positively regulated cell survival which was the opposite with ferroptosis. In conclusion, GPX4 and ferroptosis regulated the progression of TMJOA. Targeting ferroptosis might be an effective therapeutic strategy for TMJOA patients in the clinic.
The moderating role of conscientiousness in the temporal association of stress on sleep
Authors: Quaedflieg Conny W. E. M. , Bossi Camilla , Bruijel Jessica 
Published: April 2024

SummaryPersonality traits have been associated with sleep problems and stress experience. However, their impact on objective sleep and the temporal relationship of stress on sleep has remained elusive. This study examined whether daytime stress predicts sleep the following night, and the moderating role of neuroticism and conscientiousness in this relationship. To introduce stress variability in natural daily stressors, we measured college students (N = 92) during exams (e.g. high academic stress) and at the start of new course period (e.g. low academic stress). Both objective (actigraphy) and subjective sleep, and daily self‐reported stress, were measured for 14 days and personality traits once. Reported daily stress was significantly higher in the exam period compared with baseline, suggesting that our natural manipulation did indeed result in variation in stress levels. Intra‐individual daily variations in stress were not associated with the following night's sleep timing, duration or fragmentation, implying that more stress during the day did not affect sleep the following night. Higher levels of neuroticism were associated with poorer daily subjective sleep quality and higher stress levels over the complete period. Neuroticism did not moderate the temporal association of stress on sleep. Conscientiousness moderated the association between intra‐individual stress and sleep fragmentation, and intra‐individual stress and wake‐up time. This implied that highly conscientious participants experienced less sleep fragmentation and woke‐up earlier after more stressful days. These results suggest an interconnected relationship among stress, sleep and personality. Focusing on one aspect, like handling stress or enhancing sleep quality, might yield positive effects on the rest.
Older people's experiences of vulnerability in a trust‐based welfare society affected by the COVID‐19 pandemic
Authors: Lausund Hilde , Jøranson Nina , Breievne Grete , Myrstad Marius , Heiberg Kristi Elisabeth , Walle‐Hansen Marte Meyer , Heggestad Anne Kari Tolo 
Published: April 2024

AbstractThe early coronavirus disease 2019 (COVID‐19) outbreak inflicted vulnerability on individuals and societies on a completely different scale than we have seen previously. The pandemic developed rapidly from 1 day to the next, and both society and individuals were put to the test. Older people's experiences of the early outbreak were no exception. Using an abductive analytical approach, the study explores the individual experiences of vulnerability as described by older people hospitalised with COVID–19 in the early outbreak. In these older people, we found that the societal context and the individual experiences of vulnerability were inextricable linked. The study demonstrates that despite significant individual stress, informants displayed an interesting ability to also view their situation to reorient their perspective. The experience of vulnerability is both conditional and individual, which imposes a degree of unpredictability that neither they nor others were able to negotiate. The article discusses the phenomenon of unpredictability in light of a modern society with regard to how individuals and society may encounter unexpected events in the future where the potential to reorient will be vital.
ISPP presidential address: Why political psychology (and ISPP) benefit from including work (and members) from varieties of political systems, positions and locations, political cultures, theories, and methods
Authors: Pratto Felicia 
Published: April 2024

AbstractPolitical psychology has greatly benefited from work that together addresses the enormous variety of political problems faced by people around the world, including those that are universal (e.g., how one gains access to basic needs, how power should be governed) and problems that confront people in particular situations (e.g., transitions of governmental forms, war, group exclusion, rapid economic change, decolonization, external intervention, national dominance). Adopting multiple standpoints and research agendas is necessary for us collectively to make our work useful to publics and to further the work each of us does. Another strength of our discipline is to employ the assumptions of multiple disciplines and of a variety of research methods. I will illustrate these points with research examples from several ISPP members and discuss ways that those in our discipline try to confront the difficulties that lack of commonality in theory, standpoint, methods, and epistemological assumptions can pose. Finally, I will summarize some of the work that various ISPP members have done to promote the development of political psychology and our society this year and invite further suggestions and contributions from members in how we can serve one another.
Research in brief: How prevalent is rough sex? Results from a national online sample of adults in Germany
Authors: Döring Nicola , Mohseni M. Rohangis , Pietras Laura , Dekker Arne , Briken Peer 
Published: April 2024

AbstractBackgroundRough sex refers to consensual sexual activities that incorporate playful aggression, such as hair pulling, spanking, or choking. It is relevant in the context of sexual health as it can enhance sexual arousal, pleasure, and intimacy among consenting partners. However, it can also be associated with consent violations, discomfort, and injuries ranging from mild to severe or even fatal. The prevalence of rough sex in Germany is widely unknown. Our study aims to establish, for the first time, the overall age‐related and gender‐related prevalence rates of active and passive rough sex involvement among adults in Germany.MethodsA national online sample of 1101 adults from Germany, aged 18–69 years (50% men, 49% women, 1% gender‐diverse individuals) gave informed consent and reported on their lifetime engagement in rough sex in active and passive roles. We recruited participants through a professional panel provider for a multi‐themed sexual health survey. Data analysis was conducted using R, with 95% confidence intervals of prevalence rates computed to answer the research questions.ResultsLifetime prevalence of rough sex involvement was 29%. Adults below the age of 40 reported higher rates of involvement (up to 43%) than people over 40 (up to 26%). Men reported predominantly active role involvement and women reported primarily passive role involvement.DiscussionResults show that rough sex is common. Sexual health professionals, educators, and researchers should be prepared to guide current and aspiring practitioners of rough sex, helping them understand potential benefits, risks, and age‐ and gender‐related differences.
Innovating medical education: Development of an affordable, 3‐D printed knot‐tying simulator
Authors: Pourak Kian , Zugris Nicholas , Palmon Itai , Monovoukas Demetri , Waits Seth 
Published: April 2024

AbstractBackgroundThree‐dimensional (3‐D) printing offers an innovative option to produce clinical simulators because of its low production costs and widespread availability. We aimed to develop a low‐cost, 3‐D printed knot‐tying simulator that overcomes the barriers students face in self‐directed skills development.ApproachMedical students completing a procedural residency preparation course (PRPC) completed a pre‐survey with Likert scales and multiple choice questions to assess their perceptions of and barriers to self‐directed knot‐tying practice. Subsequently, a 3‐D printed knot‐tying simulator, which contains a progression of knot‐tying challenges and a designated video curriculum, was designed. After utilising the simulator in a 1‐hour, faculty‐guided knot‐tying session, PRPC students assessed the educational utility and usability of the simulator via a post‐survey.EvaluationThe primary barriers students faced in engaging in self‐directed knot‐tying practice included limited accessibility to simulators and insufficient knowledge of knot‐tying techniques. Many students (91.3%, n = 21) agreed that practicing with the simulator improved their knot‐tying motor skills and was easy to use (100%, n = 23). Twenty‐two (95.7%) students agreed that they would continue to use the simulator beyond the knot‐tying session and PRPC.ImplicationsWe demonstrate the educational utility and usability of a novel 3‐D printed knot‐tying simulator for medical education. Enabling students to engage in self‐directed technical skills development is critical in developing surgical skills that can translate to clinical environments. Our simulator highlights the benefits of 3‐D printers as an innovative, inexpensive option to improve the availability and accessibility to medical education tools.
The time‐asymptotic expansion for the compressible Euler equations with damping
Authors: Huang Feimin , Wu Xiaochun 
Published: April 2024

AbstractIn 1992, Hsiao and Liu first showed that the solution to the compressible Euler equations with damping time‐asymptotically converges to the diffusion wave of the porous media equation. Geng et al. proposed a time‐asymptotic expansion around the diffusion wave , which is a better asymptotic profile than . In this paper, we rigorously justify the time‐asymptotic expansion by the approximate Green function method and the energy estimates. Moreover, the large time behavior of the solution to compressible Euler equations with damping is accurately characterized by the time‐asymptotic expansion.
Laboratory Demonstration of Grating Embedded Mirrors for Single-Shot Heliostat Optical Metrology
Authors: Wisniewski Hayden J. , Arnold Ian J. , Kim Daewook , Zuo Heng E. , Chalifoux Brandon D. 
Published: April 2024

Abstract
Concentrated solar power (CSP) plants need to monitor the surface slope error of thousands of heliostats with sub-milliradian accuracy. Large numbers of heliostats installed in harsh environments mean that measurement speed and durability are key design considerations for metrology systems. We present a compact, accurate, and high-speed heliostat slope error metrology system that is robust to the harsh environmental conditions at CSP plants. The system is composed of (1) grating embedded mirrors (GEMs), which have multiple different phase diffraction gratings written within a glass mirror substrate, and (2) a compact optical system, the diffractive auto-stigmatic Hartmann camera (DASHCam). Using focused ultrafast laser pulses, we write phase gratings within second-surface float glass mirror without damaging the reflective coating on the backside. The gratings direct a small fraction of incident light to non-specular directions, which the DASHCam senses from a virtual center of curvature to measure the mirror slopes at each grating patch. In a CSP plant, each heliostat mirror would be a GEM, and the DASHCam would rapidly measure slope and canting errors during heliostat manufacturing, installation, or operation. We fabricated 0.1 meter-diameter GEMs with 24 grating patches, built a prototype DASHCam system, and tested the system repeatability and accuracy by comparing against a Fizeau interferometer. Our results show, in a laboratory environment, 24μrad root mean square (RMS) measurement repeatability and 47μrad RMS accuracy, with single-shot image capture. The combination of GEMs and DASHCam is a promising metrology approach that could lead to improved optical accuracy of heliostats throughout their life cycle. This work serves as a proof of principle for this system.
Practice Design and Coaching to Support Learning in Elite Youth Soccer Players: Recommendations From International Coaches, Coach Educators, and Researchers
Authors: Bergmann Fynn , Wachsmuth Svenja , O’Connor Donna , Larkin Paul , Dugandzic Damir , Höner Oliver 
Published: April 2024

Providing optimal learning support is a major challenge within talent development settings. To accomplish this challenge, practitioners’ decisions, and actions should be informed by a blend of practical experiences and academic knowledge. This study explored experts’ recommendations on how to facilitate learning in elite adolescent soccer players during practice. Special focus was dedicated to why certain practice and coaching approaches were recommended to better understand experts’ justifications. Eighteen semistructured interviews were conducted with international experts representing three complementary groups of expertise (i.e., six of each soccer coaches; coach educators/developers; and researchers in talent development, motor learning, or coaching pedagogy). By employing a reflexive thematic analysis three themes were constructed: (I) differentiating overarching learning goals to address players’ individual needs, (II) designing purposeful training sessions with the game in mind, and (III) coaching interventions to support player learning within a group environment. Overall, the experts recommended the complementary use of different practice and coaching strategies to address individual learning needs. While some strategies may be associated with conflicting theoretical paradigms and established pedagogical approaches, the findings inform a purposeful integration of those different approaches in practical work. Therefore, participants’ recommendations can be discussed by integrating interdisciplinary theoretical perspectives.
Measurement Reactivity in Ecological Momentary Assessment Studies of Movement-Related Behaviors
Authors: Maher Jaclyn P. , Arigo Danielle , Baga Kiri , Salvatore Gabrielle M. , Pasko Kristen , Hudgins Brynn L. , König Laura M. 
Published: April 2024

Measurement reactivity has implications for behavioral science, as it is crucial to determine whether changes in constructs of interest represent true change or are an artifact of assessment. This study investigated whether measurement reactivity occurs for movement-related behaviors, motivational antecedents of behavior, and associations between them. Data from ecological momentary assessment studies of older adults (n = 195) and women in midlife (n = 75) lasting 8–10 days with 5–6 prompts/day and ambulatory monitoring of movement were used for this secondary data analysis. To examine potential drop-off patterns indicative of measurement reactivity, multilevel models tested whether behavior, antecedents, and associations changed after the first or first 2 prompts compared with remaining prompts and the first, first 2, or first 3 days compared with remaining days. Older adults’ sedentary behavior was lower, and time spent upright and intentions and self-efficacy to stand/move were higher on the first 2 and first 3 days compared with remaining days. Associations between intentions and self-efficacy and subsequent sedentary behavior were weaker earlier in the study compared to later. For women in midlife, light physical activity was higher at the first and first 2 prompts compared with remaining prompts, and physical activity motivation was higher across all prompts and days tested. There was a stronger association between intended and observed minutes of moderate to vigorous physical activity on the first 2 days compared with remaining days. Measurement reactivity appeared as expected for movement-related behaviors and motivational antecedents, though changes in associations between these constructs are likely do not reflect measurement reactivity.
Efficacy of an oral lipid nanocrystal formulation of amphotericin B (MAT2203) in the neutropenic mouse model of pulmonary mucormycosis
Authors: Gu Yiyou , Gebremariam Teclegiorgis , Alkhazraji Sondus , Youssef Eman , El-Gamal Sabrina , Matkovits Theresa , Cobb Jenel , Mannino Raphael , Ibrahim Ashraf S. 
Published: April 2024

ABSTRACT

Invasive mucormycosis (IM) is associated with high mortality and morbidity. MAT2203 is an orally administered lipid nanocrystal formulation of amphotericin B, which has been shown to be safe and effective against other fungal infections. We sought to compare the efficacy of MAT2203 to liposomal amphotericin B (LAMB) treatment in a neutropenic mouse model of IM due to
Rhizopus arrhizus
var.
delemar
or
Mucor circinelloides f. jenssenii
DI15-131. In
R. arrhizus
var.
delemar
-infected mice, 15 mg/kg of MAT2203 qd was as effective as 10 mg/kg of LAMB in prolonging median survival time vs placebo (13.5 and 16.5 days for MAT2203 and LAMB, respectively, vs 9 days for placebo) and enhancing overall survival vs placebo-treated mice (40% and 45% for MAT2203 and LAMB, respectively, vs 0% for placebo). A higher dose of 45 mg/kg of MAT2203 was not well tolerated by mice and showed no benefit over placebo. Similar results were obtained with mice infected with
M. circinelloides
. Furthermore, while both MAT2203 and LAMB treatment resulted in a significant reduction of ~1.0–2.0log and ~2.0–2.5log in
Rhizopus delemar
or
M. circinelloides
lung and brain burden vs placebo mice, respectively, LAMB significantly reduced tissue fungal burden in mice infected with
R. delemar
vs tissues of mice treated with MAT2203. These results support continued investigation and development of MAT2203 as a novel and oral formulation of amphotericin for the treatment of mucormycosis.
Advancing metagenome-assembled genome-based pathogen identification: unraveling the power of long-read assembly algorithms in Oxford Nanopore sequencing
Authors: Chen Zhao , Grim Christopher J. , Ramachandran Padmini , Meng Jianghong 
Published: April 2024

ABSTRACT

Oxford Nanopore sequencing is one of the high-throughput sequencing technologies that facilitates the reconstruction of metagenome-assembled genomes (MAGs). This study aimed to assess the potential of long-read assembly algorithms in Oxford Nanopore sequencing to enhance the MAG-based identification of bacterial pathogens using both simulated and mock communities. Simulated communities were generated to mimic those on fresh spinach and in surface water. Long reads were produced using R9.4.1+SQK-LSK109 and R10.4 + SQK-LSK112, with 0.5, 1, and 2 million reads. The simulated bacterial communities included multidrug-resistant
Salmonella enterica
serotypes Heidelberg, Montevideo, and Typhimurium in the fresh spinach community individually or in combination, as well as multidrug-resistant
Pseudomonas aeruginosa
in the surface water community. Real data sets of the ZymoBIOMICS HMW DNA Standard were also studied. A bioinformatic pipeline (MAGenie, freely available at
https://github.com/jackchen129/MAGenie
) that combines metagenome assembly, taxonomic classification, and sequence extraction was developed to reconstruct draft MAGs from metagenome assemblies. Five assemblers were evaluated based on a series of genomic analyses. Overall, Flye outperformed the other assemblers, followed by Shasta, Raven, and Unicycler, while Canu performed least effectively. In some instances, the extracted sequences resulted in draft MAGs and provided the locations and structures of antimicrobial resistance genes and mobile genetic elements. Our study showcases the viability of utilizing the extracted sequences for precise phylogenetic inference, as demonstrated by the consistent alignment of phylogenetic topology between the reference genome and the extracted sequences. R9.4.1+SQK-LSK109 was more effective in most cases than R10.4+SQK-LSK112, and greater sequencing depths generally led to more accurate results.

IMPORTANCE

By examining diverse bacterial communities, particularly those housing multiple
Salmonella enterica
serotypes, this study holds significance in uncovering the potential of long-read assembly algorithms to improve metagenome-assembled genome (MAG)-based pathogen identification through Oxford Nanopore sequencing. Our research demonstrates that long-read assembly stands out as a promising avenue for boosting precision in MAG-based pathogen identification, thus advancing the development of more robust surveillance measures. The findings also support ongoing endeavors to fine-tune a bioinformatic pipeline for accurate pathogen identification within complex metagenomic samples.