bluuebunny/crossref_metadata_2025_split huggingface dataset:
Zero‐shot insect detection via weak language supervision
Authors: Feuer Benjamin , Joshi Ameya , Cho Minsu , Chiranjeevi Shivani , Deng Zi Kang , Balu Aditya , Singh Asheesh K. , Sarkar Soumik , Merchant Nirav , Singh Arti , Ganapathysubramanian Baskar , Hegde Chinmay 
Published: May 2024

AbstractCheap and ubiquitous sensing has made collecting large agricultural datasets relatively straightforward. These large datasets (for instance, citizen science data curation platforms like iNaturalist) can pave the way for developing powerful artificial intelligence (AI) models for detection and counting. However, traditional supervised learning methods require labeled data, and manual annotation of these raw datasets with useful labels (such as bounding boxes or segmentation masks) can be extremely laborious, expensive, and error‐prone. In this paper, we demonstrate the power of zero‐shot computer vision methods—a new family of approaches that require (almost) no manual supervision—for plant phenomics applications. Focusing on insect detection as the primary use case, we show that our models enable highly accurate detection of insects in a variety of challenging imaging environments. Our technical contributions are two‐fold: (a) We curate the Insecta rank class of iNaturalist to form a new benchmark dataset of approximately 6 million images consisting of 2526 agriculturally and ecologically important species, including pests and beneficial insects. (b) Using a vision‐language object detection method coupled with weak language supervision, we are able to automatically annotate images in this dataset with bounding box information localizing the insect within each image. Our method succeeds in detecting diverse insect species present in a wide variety of backgrounds, producing high‐quality bounding boxes in a zero‐shot manner with no additional training cost. This open dataset can serve as a use‐inspired benchmark for the AI community. We demonstrate that our method can also be used for other applications in plant phenomics, such as fruit detection in images of strawberry and apple trees. Overall, our framework highlights the promise of zero‐shot approaches to make high‐throughput plant phenotyping more affordable.
Taraxerone exerts antipulmonary fibrosis effect through Smad signaling pathway and antioxidant stress response in a Sirtuin1‐dependent manner
Authors: Chen Ziwei , Xie Weixi , Tang Siyuan , Lin Miao , Ren Lu , Huang Xiaoting , Deng Lang , Qian Rui , Wang Zun , Xiong Dayang , Xie Pingli , Liu Wei 
Published: May 2024

AbstractIdiopathic pulmonary fibrosis treatments are limited, often with severe side effects, highlighting the need for novel options. Taraxerone has diverse biomedical properties, but its mechanism remains unclear. This study investigates taraxerone's impact and the mechanisms involved in bleomycin‐induced pulmonary fibrosis in mice. After establishing a pulmonary fibrosis mouse model, taraxerone was intraperitoneally injected continuously for 14–28 days. The in vivo antifibrotic and antioxidative stress effects of taraxerone were assessed. In vitro, the influence of taraxerone on transforming growth factor‐β1‐induced myofibroblast transformation and oxidative stress was investigated. Subsequently, quantitative polymerase chain reaction screened the histone deacetylase and Sirtuin family, and taraxerone's effects on SIRT1 were assessed. After SIRT1 siRNA treatment, changes in myofibroblast transformation and antioxidant capacity in response to taraxerone were observed. Acetylation and phosphorylation levels of Smad3 were evaluated. We also examined the binding levels of SIRT1 with Pho‐Smad3 and Smad3, as well as the nuclear localization of Smad2/3. EX527 confirmed SIRT1's in vivo action in response to taraxerone. In vitro experiments suggested that taraxerone inhibited myofibroblast differentiation by activating SIRT1 and reducing oxidative stress. We also observed a new interaction between SIRT1 and the Smad complex. Taraxerone activates SIRT1, enabling it to bind directly to Smad3. This leads to reduced Smad complex phosphorylation and limited nuclear translocation. As a result, the transcription of fibrotic factors is reduced. In vivo validation confirms taraxerone's SIRT1‐mediated antifibrotic effectiveness. This suggests that targeting SIRT1‐mediated inhibition of myofibroblast differentiation could be a key strategy in taraxerone‐based therapy for pulmonary fibrosis.
Cascaded Nanozyme Based pH‐Responsive Oxygenation for Targeted Eradication of Resistant Helicobacter Pylori
Authors: Tong Yue , Liu Qian , Fu Hongli , Han Mengfan , Zhu Hanchen , Yang Kun , Xu Le , Meng Meng , Yin Yongmei , Xi Rimo 
Published: May 2024

AbstractNanozymes, as substitutes for natural enzymes, are constructed as cascade catalysis systems for biomedical applications due to their inherent catalytic properties, high stability, tunable physicochemical properties, and environmental responsiveness. Herein, a multifunctional nanozyme is reported to initiate cascade enzymatic reactions specific in acidic environments for resistant Helicobacter pylori (H. pylori) targeting eradication. The cobalt‐coated Prussian blue analog based FPB‐Co‐Ch NPs displays oxidase‐, superoxide dismutase‐, peroxidase‐, and catalase‐ mimicking activities that trigger • and H2O2 to supply O2, thereby killing H. pylori in the stomach. To this end, chitosan is modified on the surface to exert bacterial targeted adhesion and improve the biocompatibility of the composite. In the intestinal environment, the cascade enzymatic activities are significantly inhibited, ensuring the biosafety of the treatment. In vitro, sensitive and resistant strains of H. pylori are cultured and the antibacterial activity is evaluated. In vivo, murine infection models are developed and its success is confirmed by gastric mucosal reculturing, Gram staining, H&E staining, and Giemsa staining. Additionally, the antibacterial capacity, anti‐inflammation, repair effects, and biosafety of FPB‐Co‐Ch NPs are comprehensively investigated. This strategy renders a drug‐free approach that specifically targets and kills H. pylori, restoring the damaged gastric mucosa while relieving inflammation.
High‐Throughput Growth of Armored Perovskite Single Crystal Fibers for Pixelated Arrays
Authors: Li Cuicui , Ye Xin , Jiang Jinke , Guo Qing , Zheng Xiaoxin , Lin Qinglian , Ge Chao , Wang Shuwen , Chen Jiashuai , Gao Zeliang , Zhang Guodong , Tao Xutang , Liu Yang 
Published: May 2024

AbstractThe poor machinability of halide perovskite crystals severely hampered their practical applications. Here a high‐throughput growth method is reported for armored perovskite single‐crystal fibers (SCFs). The mold‐embedded melt growth (MEG) method provides each SCF with a capillary quartz shell, thus guaranteeing their integrality when cutting and polishing. Hundreds of perovskite SCFs, exemplified by CsPbBr3, CsPbCl3, and CsPbBr2.5I0.5, with customized dimensions (inner diameters of 150–1000 µm and length of several centimeters), are grown in one batch, with all the SCFs bearing homogeneity in shape, orientation, and optical/electronic properties. Versatile assembly protocols are proposed to directly integrate the SCFs into arrays. The assembled array detectors demonstrated low‐level dark currents (< 1 nA) with negligible drift, low detection limit (< 44.84 nGy s−1), and high sensitivity (61147 µC Gy−1 cm−2). Moreover, the SCFs as isolated pixels are free of signal crosstalk while showing uniform X‐ray photocurrents, which is in favor of high spatial resolution X‐ray imaging. As both MEG and the assembly of SCFs involve none sophisticated processes limiting the scalable fabrication, the strategy is considered to meet the preconditions of high‐throughput productions.
In situ Crystallization of Methanesulfonic Acid, CH3SO3H, and Serendipitous Single Crystal Formation of its Anhydride, (CH3)2S2O5
Authors: van Gerven David , Mertens Alisha , Eppers Katrin , Nickelsen Jasper , Wickleder Mathias S. 
Published: May 2024

AbstractMethanesulfonic acid, CH3SO3H, has been crystallized using an in situ technique on a single crystal diffractometer. The crystal structure is monoclinic (P21/c, Z=4, a=842.07(4) pm, b=582.20(3) pm, c=820.38(4) pm, β=106.459(2)°) and stamped by the presence of strong hydrogen bonds. Single crystals of the anhydride of methanesulfonic acid, (CH3)2S2O5, formed as a side product in the reaction of bis‐trimethylsilyl‐sulfate, [(CH3)3SiO]2SO2 with SO3 in a sealed glass ampoule. The monoclinic crystal structure (P21/n, Z=12, a=1794.5(2) pm, b=831.75(7) pm, 1383.4(1) pm, β=110.630(4)°) shows three crystallographically different (CH3)2S2O5 molecules in the unit cell. According to the orientation of the CH3 groups with respect to each other the (CH3)2S2O5 molecule appears as the so‐called trans‐conformer. The structure of both molecules is corroborated by quantum mechanical DFT calculations.
A preliminary study of roxadustat in the treatment of aplastic anemia patients with inadequate erythroid responses
Authors: Shi Yimeng , Zhao Yufei , Liang Weiru , Zhang Baohang , Kang Rui , Yang Wenrui , Zhao Xin , Zhang Fengkui 
Published: May 2024

AbstractSome aplastic anemia(AA) patients only have partial hematological responses after immunosuppressive therapy. Failure to achieve complete normalization of blood counts, particularly hemoglobin, will reduce their quality of life. This open-label pilot study was conducted to evaluate the efficacy and safety of roxadustat in this setting. A total of 14 patients with AA who had inadequate erythroid response after immunosuppressive therapy were included in the study. The primary efficacy endpoint was hemoglobin response at week 8 after roxadustat treatment. The median duration of roxadustat therapy was 14 (4–30) weeks, with 12 patients receiving roxadustat for ≥ 8 weeks. At week 8, nine patients (9/14, 64.3%) had their hemoglobin rising for at least 15 g/L, with two patients (2/14, 14.3%) achieving normal hemoglobin levels. By the last follow-up, hemoglobin responses were observed in 10 patients (10/14, 71.4%), with 4 patients(4/14, 28.6%) having normal hemoglobin levels. Roxadustat was tapered or discontinued in four responded patients; one relapsed after 12 weeks of tapering, and three maintained their response. Four patients (4/14, 28.6%) experienced mild adverse effects during therapy. Roxadustat is safe and well tolerated by patients with AA. Treatment with the hypoxia-inducible factor prolyl hydroxylase inhibitor improves hemoglobin levels in AA patients with inadequate erythroid responses.
Effects of Thickening Agents on the Mucociliary Transport Function: Comparison by the Type of Thickening Agents and the Viscosity of Thickened Water
Authors: Matsumura Erika , Nohara Kanji , Fukatsu Hikari , Tanaka Nobukazu , Fujii Nami , Sakai Takayoshi 
Published: May 2024

Abstract
Thickening agents effectively prevent liquid aspiration, but their impact on the ease of discharging aspirated liquids from the trachea remains unclear due to alterations in the physical properties of liquids. This study clarifies the effects of thickening agents, comprising various raw materials, on mucociliary transport function, focusing on the viscosities of thickened waters. The subjects were 23 healthy adults. Five types of saccharin solution were prepared: a solution without a thickening agent, a starch-based nectar-like solution, a starch-based honey-like solution, a xanthan-gum-based nectar-like solution, and a xanthan-gum-based honey-like solution. Using these five types of saccharin solutions randomly, each subject underwent five trials of the saccharine dye test to evaluate the mucociliary transport function of the respiratory tract. The saccharin time was defined as the time from the placement of the saccharin solution on the nasal vestibule of the subject to when the subject reported that they became aware of the sweetness. The saccharin transit times for all samples of thickened water were longer compared to those of water without a thickening agent (p < 0.01). A comparison between thickened water samples with different viscosities showed that the saccharin transit time was longer when thickened water samples with high viscosity were prepared using the same thickening agent (p < 0.01). This suggests that while thickening reduces aspiration, the use of thickening agents may increase the difficulty in discharging aspirated fluids from the trachea.
Validation and responsiveness of the English version of the Chemotherapy-Induced Alopecia Distress Scale (CADS) in breast cancer patients
Authors: Kraehenbuehl L. , Kang D. , Bang A. S. , Ketosugbo K. F. , Hay J. , Patil Sujata , Goldfarb S. , Cho J. , Lacouture M. E. 
Published: May 2024

Abstract
Purpose
This study aimed to validate the Chemotherapy-Induced Alopecia Distress Scale (CADS) in a diverse English-speaking population and patients with endocrine treatment-induced alopecia (EIA).

Objective
Chemotherapy and endocrine therapy commonly cause alopecia in breast cancer patients, leading to significant psychological and social challenges. The CADS was developed to assess the psychosocial impact of alopecia, but its generalizability beyond Korean patients requires further investigation.

Methods
Data from the CHANCE study (NCT02530177), which focused on non-metastatic breast cancer, was used. The cohort included 256 patients, and CADS data were collected at baseline, 6 months after chemotherapy completion, or 12 months after initiating endocrine therapy. The CADS questionnaire comprised 17 items covering physical and emotional health, daily activities, and relationships. Reliability was assessed using Cronbach’s alpha, and responsiveness was measured by effect size.

Results
The CADS exhibited good reliability, with Cronbach’s alpha of 0.91 for the overall score, indicating acceptable internal consistency in both chemotherapy (0.89) and endocrine therapy (0.86) groups. Longitudinal responsiveness was supported by an effect size of 0.49 between decreasing satisfaction with hair growth and increasing emotional distress. Cross-sectional validity was confirmed, with effect sizes of 0.91 and 0.92 for satisfaction with hair growth and emotional and activity domains, respectively.

Conclusion
The CADS is a valid and responsive tool for assessing the psychosocial impact of chemotherapy-induced alopecia and endocrine treatment-induced alopecia in a diverse Western patient population.
Predicting first time depression onset in pregnancy: applying machine learning methods to patient-reported data
Authors: Krishnamurti Tamar , Rodriguez Samantha , Wilder Bryan , Gopalan Priya , Simhan Hyagriv N. 
Published: May 2024

Abstract

Purpose
To develop a machine learning algorithm, using patient-reported data from early pregnancy, to predict later onset of first time moderate-to-severe depression.

Methods
A sample of 944 U.S. patient participants from a larger longitudinal observational cohortused a prenatal support mobile app from September 2019 to April 2022. Participants self-reported clinical and social risk factors during first trimester initiation of app use and completed voluntary depression screenings in each trimester. Several machine learning algorithms were applied to self-reported data, including a novel algorithm for causal discovery. Training and test datasets were built from a randomized 80/20 data split. Models were evaluated on their predictive accuracy and their simplicity (i.e., fewest variables required for prediction).

Results
Among participants, 78% identified as white with an average age of 30 [IQR 26–34]; 61% had income ≥ $50,000; 70% had a college degree or higher; and 49% were nulliparous. All models accurately predicted first time moderate-severe depression using first trimester baseline data (AUC 0.74–0.89, sensitivity 0.35–0.81, specificity 0.78–0.95). Several predictors were common across models, including anxiety history, partnered status, psychosocial factors, and pregnancy-specific stressors. The optimal model used only 14 (26%) of the possible variables and had excellent accuracy (AUC = 0.89, sensitivity = 0.81, specificity = 0.83). When food insecurity reports were included among a subset of participants, demographics, including race and income, dropped out and the model became more accurate (AUC = 0.93) and simpler (9 variables).

Conclusion
A relatively small amount of self-report data produced a highly predictive model of first time depression among pregnant individuals.
Five-year follow-up of the iBerry Study: screening in early adolescence to identify those at risk of psychopathology in emerging adulthood
Authors: Bouter D. C. , Ravensbergen S. J. , de Neve-Enthoven N. G. M. , Zarchev M. , Mulder C. L. , Hoogendijk W. J. G. , Roza S. J. ,   ESPRi Consortium, van Beek Wim , Hagestein-de Bruijn Carla , Kouijzer Mirjam E. J. , de Ridder Alex J. M. , van ’t Hooft-Nguyen Chi M. , Veen Natalie D. , Michielsen Philip J. S. , de Jong Mark H. , Grootendorst-van Mil N. H. 
Published: May 2024

AbstractThe iBerry Study, a Dutch population-based high-risk cohort (n = 1022) examines the transition from subclinical symptoms to psychiatric disorders in adolescents. Here, we present the first follow-up measurement, approximately 3 years after baseline assessment and 5 years after the screening based on self-reported emotional and behavioral problems (SDQ-Y). We give an update on the data collection, details on the (non)response, and the results on psychopathology outcomes. The first follow-up (2019–2022) had a response rate of 79% (n = 807). Our results at baseline (mean age 15.0 years) have shown the effectiveness of using the SDQ-Y to select a cohort oversampled for the risk of psychopathology. At first follow-up (mean age 18.1 years), the previously administered SDQ-Y remains predictive for selecting adolescents at risk. At follow-up, 47% of the high-risk adolescents showed significant mental health problems based on self- and parent reports and 46% of the high-risk adolescents met the criteria for multiple DSM-5 diagnoses. Compared to low-risk adolescents, high-risk adolescents had a sevenfold higher odds of significant emotional and behavioral problems at follow-up. Comprehensive assessment on psychopathology, substance abuse, psychotic symptoms, suicidality, nonsuicidal self-injury, addiction to social media and/or video gaming, and delinquency, as well as social development, and the utilization of healthcare and social services were conducted. This wave, as well as the ones to follow, track these adolescents into their young adulthood to identify risk factors, elucidate causal mechanisms, and discern pathways leading to both common and severe mental disorders. Results from the iBerry Study will provide leads for preventive interventions.
Iloprost infusion reduces serological cytokines and hormones of hypoxia and inflammation in systemic sclerosis patients
Authors: Pellicano Chiara , Colalillo Amalia , De Marco Oriana , Carnazzo Valeria , Basile Umberto , Gigante Antonietta , Cianci Rosario , Rosato Edoardo 
Published: May 2024

Abstract
Introduction
Systemic sclerosis (SSc) is characterized by microvascular damage of skin and internal organs with chronic hypoxia and release of cytokines and hormones such as neutrophil gelatinase-associated lipocalin (NGAL), fibroblast growth factor-23 (FGF-23) and Klotho. Aim of the study was to evaluate FGF-23, Klotho and NGAL serum levels in SSc patients and healthy controls (HC) and to evaluate serum levels changes of FGF-23, Klotho and NGAL after Iloprost.

Methods
Twenty-one SSc patients and 20 HC were enrolled. In SSc patients, peripheral venous blood samples were collected at the first day before the autumn Iloprost infusion (t0), 60 min (t1) and 14 days after Iloprost infusion (t2).

Results
SSc patients had higher serum level of FGF-23 [18.7 ± 6.4 pg/ml versus 3.6 ± 2.2 pg/ml, p < 0.001], Klotho [5.1 ± 0.8 pg/ml versus 2.3 ± 0.6 pg/ml, p < 0.001] and NGAL [20.9 ± 2.6 pg/ml versus 14.5 ± 1.7 pg/ml, p < 0.001] than HC.
Iloprost infusion reduces serum level of FGF-23 (18.7 ± 6.4 pg/ml versus 10.4 ± 5.5 pg/ml, p < 0.001), Klotho (5.1 ± 0.8 pg/ml versus 2.5 ± 0.6 pg/ml, p < 0.001) and NGAL (20.9 ± 2.6 pg/ml versus 15.1 ± 2.3 pg/ml, p < 0.001) between t0 and t1. The Iloprost infusion reduces serum level of FGF-23 (18.7 ± 6.4 pg/ml versus 6.6 ± 5.1 pg/ml), Klotho (5.1 ± 0.8 pg/ml versus 2.3 ± 0.4 pg/ml) and NGAL (20.9 ± 2.6 pg/ml versus 15.5 ± 1.9 pg/ml) between t0 and t2.

Conclusions
SSc patients had higher FGF-23, Klotho and NGAL than HC. Iloprost reduces serum levels of FGF-23, Klotho and NGAL.
CEO Narcissism and Credit Ratings
Authors: Hou Zehan , Fairchild Richard , Perotti Pietro 
Published: May 2024

Abstract
Prior research has investigated how narcissistic executives affect firm policies and outcomes and how these executives influence colleagues and followers. However, almost no research exists concerning the impact of narcissistic executives on external agents. We examine the case of credit ratings—where analysts are required to assess management competence and where undue management influence is a concern—to determine whether narcissistic CEOs exert an effect on their firm’s rating. Using the size of the CEO’s personal signature to measure narcissism, we find that CEO narcissism is associated with worse credit ratings. This effect is attenuated when firms face greater financial constraints, higher industry competition, and more concentrated institutional ownership. Our study contributes to the growing body of literature on CEO narcissism and suggests that these manipulative individuals are unable to exert an obvious upward influence on credit rating agencies.
Validation of the Hogg Climate Anxiety Scale
Authors: Hogg Teaghan L. , Stanley Samantha K. , O’Brien Léan V. 
Published: May 2024

AbstractAs one of the biggest environmental and equality challenges of our time, climate change is causing some people to experience climate anxiety. To address the need for valid and reliable measurement of this construct, we adapted the Hogg Eco-Anxiety Scale to measure climate anxiety in the United Kingdom (n = 501) and United States (n = 508). In both samples, we found the Hogg Climate Anxiety Scale (HCAS) was comprised of four dimensions: affective symptoms, behavioural symptoms, ruminative thoughts, and anxiety about one’s personal impact. The four-factor HCAS fit the data well, showed measurement invariance in these two samples, and all dimensions were internally consistent. Importantly, we also provide evidence for convergent validity by demonstrating that HCAS scores were positively correlated with an alternative measure of eco-anxiety and a more general indicator of worry in one’s daily life. The dimensions of the HCAS also showed distinct associations with theoretically related constructs, for example only personal impact anxiety and rumination were significant predictors of taking collective action on climate change, and personal impact anxiety was distinctly predictive of climate inequality beliefs. We recommend the HCAS as a brief (13 item) measurement tool to capture experiences of climate anxiety.