bluuebunny/crossref_metadata_2025_split huggingface dataset:
Randomized, double‐blind, multicenter evaluation of pramipexole extended release once daily in early Parkinson's disease
Authors: Hauser Robert A. , Schapira Anthony H.V. , Rascol Olivier , Barone Paolo , Mizuno Yoshikuni , Salin Laurence , Haaksma Monika , Juhel Nolwenn , Poewe Werner 
Published: July 2010

AbstractThe objective of this study was to evaluate the efficacy and safety of pramipexole extended release (ER) administered once daily in early Parkinson's disease (PD). Pramipexole immediate release (IR) administered three times daily (TID) is an efficacious and generally well‐tolerated treatment for PD. A pramipexole ER formulation is now available. We performed a randomized, double‐blind, placebo and active comparator–controlled trial in subjects with early PD. The primary efficacy and safety evaluation of pramipexole ER compared with placebo took place at week 18. Two hundred fifty‐nine subjects were randomized 2:2:1 to treatment with pramipexole ER once daily, pramipexole IR TID, or placebo. Levodopa rescue was required by 7 subjects in the placebo group (14%), 3 subjects in the pramipexole ER group (2.9%, P = 0.0160), and 1 subject in the pramipexole IR group (1.0%, P = 0.0017). Adjusted mean [standard error (SE)] change in Unified Parkinson Disease Rating Scale (UPDRS) II [activities of daily living (ADL)] + III (motor) scores from baseline to week 18, including post‐levodopa rescue evaluations, was −5.1 (1.3) in the placebo group, −8.1 (1.1) in the pramipexole ER group (P = 0.0282), and −8.4 (1.1) in the pramipexole IR group (P = 0.0153). Adjusted mean (SE) change in UPDRS ADL + motor scores, censoring post‐levodopa rescue data, was −2.7 (1.3) in the placebo group, −7.4 (1.1) in the pramipexole ER group (P = 0.0010), and −7.5 (1.1) in the pramipexole IR group (P = 0.0006). Adverse events more common with pramipexole ER than placebo included somnolence, nausea, constipation, and fatigue. Pramipexole ER administered once daily was demonstrated to be efficacious compared with placebo and provided similar efficacy and tolerability as pramipexole IR administered TID. © 2010 Movement Disorder Society
Cardiac autonomic dysfunction in idiopathic REM sleep behavior disorder
Authors: Postuma Ronald B. , Lanfranchi Paola A. , Blais Helene , Gagnon Jean‐Francois , Montplaisir Jacques Y. 
Published: July 2010

AbstractMore than 50% of persons with idiopathic REM sleep behavior disorder (RBD) will develop Parkinson's disease or Lewy body dementia. Symptom screens and metaiodobenzylguanine (MIBG)‐scintigraphy suggest autonomic abnormalities in idiopathic RBD, but it is unclear whether autonomic abnormalities can predict neurodegenerative disease. From a cohort of 99 patients with idiopathic RBD, we selected those who developed parkinsonism or dementia. These were matched by age, sex, and follow‐up duration to patients with RBD who remained disease free and to matched controls. From the polysomnographic trace performed at baseline evaluation, measures of beat‐to‐beat RR variability including time domains (mean RR‐interval and RR‐standard deviation) and frequency domains (low and high frequency components) were retrospectively assessed. Twenty‐one patients with idiopathic RBD who developed neurodegenerative disease were included (Parkinson's disease‐11, multiple system atrophy‐1, and dementia‐9). Age at PSG was 66 years, and 86% were male. PSG was performed on average 6.7 years before defined neurodegenerative disease. Comparing all patients with idiopathic RBD to controls, there were significant reductions in RR‐standard deviation (24.6 ± 2.2 ms vs. 35.2 ± 3.5 ms, P = 0.006), very low frequency components (238.6 ± 99.6 ms2 vs. 840.1 ± 188.3 ms2, P < 0.001), and low frequency components (127.8 ± 26.3 ms2 vs. 288.7 ± 66.2 ms2, P = 0.032). However, despite clear differences between patients with idiopathic RBD and controls, there were no differences in any measure between those who did or did not develop disease. RR‐variability analysis demonstrates substantial autonomic dysfunction in idiopathic RBD. However, this dysfunction is identical in patients who will or will not develop defined neurodegenerative disease. This suggests that autonomic dysfunction is linked with RBD independent of associated Parkinson's disease or Lewy body dementia. © 2010 Movement Disorder Society
The impact of stroke: insights from patients in Taiwan
Authors: Lee Ya‐Chen , Chen Yi‐Miau , Hsueh I‐Ping , Wang Yen‐Ho , Hsieh Ching‐Lin 
Published: July 2010

AbstractClinical stroke trials have been increasing interest in patient‐centred assessments such as functional status and health‐related quality of life. There is a consensus that these measurement factors must be relevant to, and obtained from, the patients of interest. The main purpose of this study was to evaluate the patients' reactions and concerns that individuals experience after having had a stroke. A focus group and individual interviews were conducted to identify and describe the patients' reactions to living with the results of a stroke. One hundred twelve patients participated in the study. Fifteen factors were identified as problems for the 112 participants. For the level of impact and importance, the highest percentages of responses rated by the participants in each factor were all towards the physical aspects of functioning such as hand/arm function and mobility. These findings provide important information on the impact of stroke that could be useful for occupational therapists in treatment planning and outcome measurement. Further research is recommended to understand the impact of a stroke on an individual's adjustment at home and in the community. Copyright © 2010 John Wiley & Sons, Ltd.
Solvent, salt and high pressure effects on the rate and equilibrium constants for the formation of tri‐n‐butylphosphoniumdithiocarboxylate
Authors: Iskhakova Gulnara G. , Kiselev Vladimir D. , van Eldik Rudi , Zahl Achim , Shihab Mehdi S. , Konovalov Alexander I. 
Published: July 2010

AbstractSolvent, salt and high pressure effects on the rate and equilibrium constants for the formation of tri‐n‐butylphosphoniumdithiocarboxylate at 298.2 K are reported. This equilibrium is shifted to the phosphobetaine in polar solvents, salt solutions and under high external pressure. The reaction volume changes dramatically on going from less polar diethyl ether (−69 cm3 mol−1) and tetrahydrofurane (THF) (−66 cm3 mol−1), to more polar acetonitrile (−39 cm3 mol−1) and acetone (−38 cm3 mol−1). Copyright © 2010 John Wiley & Sons, Ltd.
Sickness absence and full return to work after cancer: 2‐year follow‐up of register data for different cancer sites
Authors: Roelen Corné A. , Koopmans Petra C. , Groothoff Johan W. , van der Klink Jac J. , Bültmann Ute 
Published: July 2010

AbstractObjective: Cancer survival has improved in recent years, but data on return to work (RTW) after cancer are sparsely published. Therefore, this study analysed RTW after cancer.Methods: Employees diagnosed with breast cancer, genital cancer, gastro‐intestinal cancer, lung cancer, skin cancer, or blood malignancies were selected from an occupational health register. Sickness absence was followed for 2 years after diagnosis and full RTW at equal earnings as before sickness absence was assessed for each cancer site using Cox proportional hazards regression analysis stratifying for age and gender.Results: 3701 (73%) of 5074 employees with cancer had full RTW after a median duration of 290 days. Employees with lung cancer had the longest duration of sickness absence and only 45% of them had full RTW 2 years after diagnosis compared with 88% of employees with genital cancer and 87% of employees with skin cancer. Age was associated with the time to full RTW among employees with genital cancer: women aged⩾35 years had a longer time to full RTW compared with women <35 years and men aged⩾55 years had a longer time to full RTW compared with men <35 years. Gender was associated with the time to full RTW among survivors of blood malignancies with women having a longer time to full RTW than men.Conclusions: Most employees had full RTW within 2 years after the diagnosis of cancer and the time to RTW was largely independent of age and gender. Copyright © 2010 John Wiley & Sons, Ltd.
Do risk factors for persistent asthma modify lung function in infants and young children with recurrent wheeze?
Authors: Keklikian Esteban , Sanchez‐Solis Manuel , Bonina Angel Jose , Meneguzzi Alejandra , Pastor‐Vivero Maria Dolores , Mondejar‐Lopez Pedro , Garcia‐Marcos Luis 
Published: July 2010

AbstractBackgroundThere is very limited information on how the risk of persistent asthma in recurrent wheezing (RW) infants modifies their lung function early in life. The aim of this study is to compare lung function of RW infants and young children with a positive or negative asthma predictive index (API), an index previously used to anticipate asthma persistence into childhood and adolescence.MethodsTwo groups of RW infants and young children were recruited in two centres in Spain (Palma de Mallorca and Murcia). Lung function was measured according to the thoracho‐abdominal compression technique (RCT), and values of the maximal flow at functional residual capacity ${\rm (V}_{{\rm maxFRC}}^{\rm '} {\rm )}$ were expressed as Z‐scores. Other variables included in the study, as independent factors, were: gender, age, length, weight, and parental smoking habits together with information regarding API.ResultsExpressed as mean ± SD, API+ RW infants (n = 50; age in months 11.9 ± 4.9) had a lower ${\rm V}_{{\rm maxFRC}}^{\rm '} $ Z‐score than API− RW ones (n = 41; age in months 12.3 ± 6.2; −2.01 ± 0.79 vs. −1.64 ± 0.77, P = 0.026, respectively). Centre and tobacco exposition did not have an effect on lung function.ConclusionAmong RW infants and young children, those having a positive API have a significant lower lung function as measured by ${\rm V}_{{\rm maxFRC}}^{\rm '} $ at an early age. Pediatr. Pulmonol. 2010; 45:914–918. © 2010 Wiley‐Liss, Inc.
Does presenting with meconium ileus affect the prognosis of children with cystic fibrosis?
Authors: Johnson Jo‐Anne , Bush Andrew , Buchdahl Roger 
Published: July 2010

AbstractIt is a matter of debate as to what extent the long‐term outcome of cystic fibrosis (CF) is affected by presenting with meconium ileus (MI). We compared long‐term clinical outcomes of CF children who presented with MI, to those presenting with other symptoms (non‐MI) in an era of non new‐born‐screening (NBS).We collected annual lung function data between the ages of 8–15 years in terms of percent predicted first second forced expired volume (FEV1%pr), percent predicted forced vital capacity (FVC%pr), and between the ages of 2–15 years annual height and weight Z‐scores (HtZ and WtZ respectively) for children attending the Royal Brompton Hospital CF clinic. To be included in the study, subjects had to have at least five pulmonary function tests and five anthropometric measurements recorded over this period.Thirty‐eight MI and 76 non‐MI subjects were compared. There were no significant differences in genotype, sex, chronic Pseudomonas infection, or pancreatic enzyme use between the two groups. The median age of diagnosis was 1 day (MI) versus 7 months (non‐MI). There was a decline in spirometry and anthropometric variables over the study period for both MI and non‐MI groups apart from WtZ score in the non‐MI group. Mixed model analysis adjusting for potential confounders including genotype, pancreatic status, sex, chronic Pseudomonas aeruginosa lung infection, and age of diagnosis revealed no difference between the two groups in terms of lung function and growth during the time period of the study, however there was a non‐significant trend for subjects presenting with MI to do better in all four parameters.We conclude that babies presenting with MI have no worse long‐term outcome than those presenting symptomatically later in infancy, despite having undergone invasive procedures in the newborn period. This underscores the importance of early diagnosis and treatment in CF. Pediatr Pulmonol. 2010; 45:951–958. © 2010 Wiley‐Liss, Inc.
Development of a new dispenser for microbiological control agents and evaluation of dissemination by bumblebees in greenhouse strawberries
Authors: Mommaerts Veerle , Put Kurt , Vandeven Jessica , Jans Kris , Sterk Guido , Hoffmann Lucien , Smagghe Guy 
Published: July 2010

AbstractBACKGROUND: To date, in modern agriculture, biological control strategies are increasingly becoming the preferred pest management approach. However, the success of microbiological control agents (MCAs) largely depends on efficient dissemination into the crop. The pollinator‐and‐vector technology employs pollinating insects like bees for a better dissemination. In this study, a new dispenser for bumblebee workers of Bombus terrestris L. was developed. Binab‐T‐vector and Prestop‐Mix were used as two typical MCA products for dissemination.RESULTS: In a first series of experiments in the laboratory for optimisation, the newly developed dispenser was a two‐way type dispenser, 20 cm long, with two rectangular compartments and different entrance and exit holes. In addition, the amounts of MCA loaded on the workers were 10 times higher with the new dispenser as compared with the side‐by‐side passageway (SSP) dispenser. Typically, the highest amounts were recovered from the thorax and legs of the workers. In a second series of experiments under greenhouse conditions with the use of queen‐right B. terrestris hives, successful dissemination in strawberry flowers was obtained at different distances from the hive (0–8 m, 8–18 m and 18–21 m), and the workers inoculated the first, second and third flowers that were consecutively visited. In addition, the new dispenser caused no adverse effects on worker foraging intensity, whereas a dramatic reduction was scored with an SSP dispenser. Finally, the data suggested that it is necessary to refill the newly developed dispenser at 3 day intervals.CONCLUSIONS: The results demonstrated that, with the use of the newly developed dispenser, bumblebee workers carried high amounts of MCA, and this resulted in a successful dissemination of MCA into strawberry flowers. Copyright © 2010 Society of Chemical Industry
Construction by replacement: a new approach to simulation modeling
Authors: Hines James , Malone Thomas , Gonçalves Paulo , Herman George , Quimby John , Murphy‐Hoye Mary , Rice James , Patten James , Ishii Hiroshi 
Published: July 2010

AbstractSimulation modeling can be valuable in many areas of management science, but it is often costly, time‐consuming, and difficult to do. To reduce these problems, system dynamics researchers have previously developed standard pieces of model structure, called molecules, that can be reused in different models. However, the models assembled from these molecules often lacked feedback loops and generated few, if any, insights. This paper describes a new and more promising approach to using molecules in system dynamics modeling. The heart of the approach is a systematically organized library (or taxonomy) of predefined model components, or molecules, and a set of software tools for replacing one molecule with another. Users start with a simple generic model and progressively replace parts of the model with more specialized molecules from a systematically organized library of predefined components. These substitutions either create a new running model automatically or request further manual changes from the user. The paper describes our exploration using this approach to construct system dynamics models of supply chain processes in a large manufacturing company. The experiment included developing an innovative “tangible user interface” and a comprehensive catalog of system dynamics molecules. The paper concludes with a discussion of the benefits and limitations of this approach. Copyright © 2010 System Dynamics Society.
CFD Benchmark for a Single Strand Tundish (Part II)
Authors: Odenthal H.‐J. , Javurek M. , Kirschen M. , Vogl N. 
Published: July 2010

AbstractIn a comparative benchmark, nine participants of the German Steel Institute VDEh working group “Fluid Mechanics and Fluid Simulation” studied the melt flow in a 16‐t single‐strand tundish. Starting with a steady‐state simulation of the melt flow, the transient flow behaviour was simulated for an idealized ladle change involving a sudden jump in temperature and concentration. In addition, the separation of non‐metallic particles to the melt surface was examined. No guidelines and limitations were made regarding the simulation strategy. The predicted flow profiles, temperature and concentration distributions coincide with each other within a good approximation. Systematic differences in the transient temperature and turbulence fields are explained by the selection of the boundary condition at the free surface. All CFD programs reproduce the fundamental flow structure with a good degree of accuracy. The separation rate for non‐metallic particles calculated on the basis of the Lagrange Method are greater than would be expected according to theory and measurement results obtained on the water model.
NY‐ESO‐1 protein glycosylated by yeast induces enhanced immune responses
Authors: Wadle Andreas , Mischo Axel , Strahl Sabine , Nishikawa Hiroyoshi , Held Gerhard , Neumann Frank , Wullner Beate , Fischer Eliane , Kleber Sascha , Karbach Julia , Jager Elke , Shiku Hiroshi , Odunsi Kunle , Shrikant Protul A. , Knuth Alexander , Cerundolo Vincenzo , Renner Christoph 
Published: July 2010

AbstractVaccine strategies that target dendritic cells to elicit potent cellular immunity are the subject of intense research. Here we report that the genetically engineered yeast Saccharomyces cerevisiae, expressing the full‐length tumour‐associated antigen NY‐ESO‐1, is a versatile host for protein production. Exposing dendritic cells (DCs) to soluble NY‐ESO‐1 protein linked to the yeast a‐agglutinin 2 protein (Aga2p) protein resulted in protein uptake, processing and MHC class I cross‐presentation of NY‐ESO‐1‐derived peptides. The process of antigen uptake and cross‐presentation was dependent on the glycosylation pattern of NY‐ESO‐1‐Aga2p protein and the presence of accessible mannose receptors. In addition, NY‐ESO‐1‐Aga2p protein uptake by dendritic cells resulted in recognition by HLA‐DP4 NY‐ESO‐1‐specific CD4+ T cells, indicating MHC class II presentation. Finally, vaccination of mice with yeast‐derived NY‐ESO‐1‐Aga2p protein led to an enhanced humoral and cellular immune response, when compared to the bacterially expressed NY‐ESO‐1 protein. Together, these data demonstrate that yeast‐derived full‐length NY‐ESO‐1‐Aga2p protein is processed and presented efficiently by MHC class I and II complexes and warrants clinical trials to determine the potential value of S. cerevisiae as a host for cancer vaccine development. Copyright © 2010 John Wiley & Sons, Ltd.
Disiloxanediolates and Metallasilsesquioxanes of the Rare Earth Elements
Authors: Lorenz Volker , Edelmann Anja , Gießmann Stephan , Hrib Cristian G. , Blaurock Steffen , Edelmann Frank T. 
Published: July 2010

AbstractThis research report summarizes recent results in the chemistry of lanthanide disiloxanediolates and metallasilsesquioxanes. Both classes of compounds can be regarded as realistic model compounds for silica‐supported lanthanide catalysts.
The physiological advantage of an ecological filter species, Indocalamus longiauritus, over co‐occurring Fagus lucida and Castanopsis lamontii seedlings
Authors: Bai Kundong , Jiang Debing , Cao Kunfang , Liao Debao , Wan Xianchong 
Published: July 2010

AbstractIndocalamus longiauritus (a dwarf bamboo) dominates forest understory and functions as an ecological filter to hinder the regeneration of canopy tree species in many temperate forests. However, the physiological mechanism underlying the function of ecological filters is not clear. In this study, we measured leaf‐level carbon capture ability and use efficiency of the dwarf bamboo and the co‐existing Fagus lucida (beech) and Castanopsis lamontii (chinkapin) seedlings in forest understory and small gaps in a beech–chinkapin mixed forest in the summer of 2005. The results indicated that I. longiauritus exhibited greater carbon capture ability, as indexed by light‐saturated photosynthetic rate (Pmax), maximal carboxylation rate, maximal electron transport rate and carboxylation efficiency, than the co‐occurring F. lucida and C. lamontii seedlings in both forest understory and small gaps. Higher carbon capture ability in I. longiauritus was related to its greater partition of absorbed light energy to photochemistry. I. longiauritus had higher photosynthetic nitrogen use efficiency than F. lucida and C. lamontii seedlings in both light environments. However, water use efficiency (WUE) in I. longiauritus was higher than F. lucida but lower than C. lamontii. This intermediate WUE in I. longiauritus was related to its intermediate light‐saturated stomatal conductance. In addition, I. longiauritus reduced metabolic cost by increasing the ratio of Pmax to respiration rate, leading to increased net carbon balance. On the other hand, F. lucida and C. lamontii seedlings had greater plasticity of carbon capture ability and leaf structural traits, which might facilitate colonization of gaps and realization of natural regeneration in these species.
Comparative metagenomics of bathypelagic plankton and bottom sediment from the Sea of Marmara
Authors: Quaiser Achim , Zivanovic Yvan , Moreira David , López-García Purificación 
Published: July 2010

Abstract
To extend comparative metagenomic analyses of the deep-sea, we produced metagenomic data by direct 454 pyrosequencing from bathypelagic plankton (1000 m depth) and bottom sediment of the Sea of Marmara, the gateway between the Eastern Mediterranean and the Black Seas. Data from small subunit ribosomal RNA (SSU rRNA) gene libraries and direct pyrosequencing of the same samples indicated that Gamma- and Alpha-proteobacteria, followed by Bacteroidetes, dominated the bacterial fraction in Marmara deep-sea plankton, whereas Planctomycetes, Delta- and Gamma-proteobacteria were the most abundant groups in high bacterial-diversity sediment. Group I Crenarchaeota/Thaumarchaeota dominated the archaeal plankton fraction, although group II and III Euryarchaeota were also present. Eukaryotes were highly diverse in SSU rRNA gene libraries, with group I (Duboscquellida) and II (Syndiniales) alveolates and Radiozoa dominating plankton, and Opisthokonta and Alveolates, sediment. However, eukaryotic sequences were scarce in pyrosequence data. Archaeal amo genes were abundant in plankton, suggesting that Marmara planktonic Thaumarchaeota are ammonia oxidizers. Genes involved in sulfate reduction, carbon monoxide oxidation, anammox and sulfatases were over-represented in sediment. Genome recruitment analyses showed that Alteromonas macleodii ‘surface ecotype’, Pelagibacter ubique and Nitrosopumilus maritimus were highly represented in 1000 m-deep plankton. A comparative analysis of Marmara metagenomes with ALOHA deep-sea and surface plankton, whale carcasses, Peru subsurface sediment and soil metagenomes clustered deep-sea Marmara plankton with deep-ALOHA plankton and whale carcasses, likely because of the suboxic conditions in the deep Marmara water column. The Marmara sediment clustered with the soil metagenome, highlighting the common ecological role of both types of microbial communities in the degradation of organic matter and the completion of biogeochemical cycles.