bluuebunny/crossref_metadata_2025_split huggingface dataset:
Interleukin‐27 inhibits human osteoclastogenesis by abrogating RANKL‐mediated induction of nuclear factor of activated T cells c1 and suppressing proximal RANK signaling
Authors: Kalliolias George D. , Zhao Baohong , Triantafyllopoulou Antigoni , Park‐Min Kyung‐Hyun , Ivashkiv Lionel B. 
Published: January 2010

AbstractObjectiveInterleukin‐27 (IL‐27) has stimulatory and regulatory immune functions and is expressed in rheumatoid arthritis (RA) synovium. This study was undertaken to investigate the effects of IL‐27 on human osteoclastogenesis, to determine whether IL‐27 can stimulate or attenuate the osteoclast‐mediated bone resorption that is a hallmark of RA.MethodsOsteoclasts were generated from blood‐derived human CD14+ cells. The effects of IL‐27 on osteoclast formation were evaluated by counting the number of tartrate‐resistant acid phosphatase–positive multinucleated cells and measuring the expression of osteoclast‐related genes. The induction of nuclear factor of activated T cells c1 (NFATc1) and the activation of signaling pathways downstream of RANK were measured by immunoblotting. The expression of key molecules implicated in osteoclastogenesis (NFATc1, RANK, costimulatory receptors, and immunoreceptor tyrosine–based activation motif–harboring adaptor proteins) was measured by real‐time reverse transcription–polymerase chain reaction. Murine osteoclast precursors obtained from mouse bone marrow and synovial fluid macrophages derived from RA patients were also tested for their responsiveness to IL‐27.ResultsIL‐27 inhibited human osteoclastogenesis, suppressed the induction of NFATc1, down‐regulated the expression of RANK and triggering receptor expressed on myeloid cells 2 (TREM‐2), and inhibited RANKL‐mediated activation of ERK, p38, and NF‐κB in osteoclast precursors. Synovial fluid macrophages from RA patients were refractory to the effects of IL‐27. In contrast to the findings in humans, IL‐27 only moderately suppressed murine osteoclastogenesis, and this was likely attributable to low expression of the IL‐27 receptor subunit WSX‐1 on murine osteoclast precursors.ConclusionIL‐27 inhibits human osteoclastogenesis by a direct mechanism that suppresses the responses of osteoclast precursors to RANKL. These findings suggest that, in addition to its well‐known antiinflammatory effects, IL‐27 plays a homeostatic role in restraining bone erosion. This homeostatic function is compromised under conditions of chronic inflammation such as in RA synovitis.
Cardiac involvement in Churg‐Strauss syndrome
Authors: Dennert Robert M. , van Paassen Pieter , Schalla Simon , Kuznetsova Tatiana , Alzand Becker S. , Staessen Jan A. , Velthuis Sebastiaan , Crijns Harry J. , Tervaert Jan Willem Cohen , Heymans Stephane 
Published: January 2010

AbstractObjectiveChurg‐Strauss syndrome (CSS) is a rare form of systemic vasculitis. Previous studies showing cardiac involvement in CSS patients were limited in the number of patients and were often based solely on clinical manifestations. The aim of the present study was to determine in detail the incidence of cardiac involvement in a large population of ambulatory CSS patients.MethodsThirty‐two consecutive patients with CSS in remission (mean ± SD duration of disease between diagnosis and enrollment 6.1 ± 5.8 years, mean ± SD age 61 ± 10 years) who were previously unaware of cardiac involvement were compared with 32 randomly selected age‐ and sex‐matched control subjects, using clinical evaluation, electrocardiography (EKG), echocardiography, and cardiac magnetic resonance imaging (MRI).ResultsDetailed cardiac evaluation revealed a 62% prevalence of cardiac involvement in CSS patients compared with 3% in controls (P < 0.001), with clinical symptoms in 26% and 3%, respectively (P = 0.009), EKG abnormalities in 66% and 3%, respectively (P < 0.001), and echocardiographic defects in 50% and 3%, respectively (P < 0.001). Cardiac MRI detected cardiac manifestations in 62% of CSS patients. In the presence of cardiac MRI abnormalities, echocardiography could detect cardiac involvement with a sensitivity of 83% and a specificity of 80%. The absence of symptoms or EKG abnormalities did not exclude cardiac involvement, because abnormalities could still be detected in 38% of these patients at the time of echocardiography or cardiac MRI.ConclusionThese results demonstrate a high incidence of cardiac involvement in CSS patients. Systematic cardiac evaluation including detailed imaging is required to properly identify CSS patients with cardiac involvement.
Biologic predictors of extension of oligoarticular juvenile idiopathic arthritis as determined from synovial fluid cellular composition and gene expression
Authors: Hunter Patricia J. , Nistala Kiran , Jina Nipurna , Eddaoudi Ayad , Thomson Wendy , Hubank Mike , Wedderburn Lucy R. 
Published: January 2010

AbstractObjectiveTo identify biomarkers in the first synovial fluid (SF) aspirate obtained from children with oligoarticular juvenile idiopathic arthritis (JIA), which could be used to identify children whose disease is likely to extend to a more severe phenotype.MethodsPatients with recent‐onset oligoarticular JIA were identified and grouped according to those whose mild disease persisted (persistent disease) or those whose disease would extend from a mild to more severe phenotype (extended‐to‐be disease) at 1 year after diagnosis. Flow cytometry was used to delineate differences in the mononuclear cell populations between the first blood sample and first SF aspirate from the same patient and between outcome (persistent versus extended‐to‐be) groups. Proportions of lymphocytes in the joint were modeled on chemotaxis of lymphocytes to CCL5, using Transwell migration assays. Levels of CCL5 in the SF were quantified by enzyme‐linked immunosorbent assay. RNA profiles of SF mononuclear cells were compared between groups using the Affymetrix GeneChip hybridization protocol and hierarchical clustering analyses.ResultsCompared with peripheral blood mononuclear cells, SF mononuclear cells displayed an expansion of CD8+ T cells, reduced proportion of B cells, and expansion of CD16− natural killer cells. The lower CD4:CD8 ratio in the SF was recapitulated in vitro by the observed migration of blood T cells in response to CCL5. Synovial CCL5 levels were higher in children whose disease extended to a more severe phenotype. The CD4:CD8 ratio in the SF was significantly lower in patients with extended‐to‐be oligoarticular JIA (0.57 compared with 0.90 in the persistent disease group, difference 0.33, 95% confidence interval 0.04–0.62; P = 0.009). Gene expression profiling revealed that 344 genes were >1.5‐fold differentially expressed between outcome groups (P < 0.05), and these included genes associated with inflammation and macrophage differentiation, which showed increased levels in patients with extended disease at 1 year, and genes associated with immune regulation, which showed increased levels in patients with persistent disease at 1 year.ConclusionAnalyses of the proportions of synovial lymphocytes, levels of CCL5, and differential gene expression yielded potential biomarkers with which to predict the likelihood of extension of oligoarticular JIA to a more severe disease phenotype.
Near‐peer role modeling: The fledgling scholars education paradigm
Authors: Singh Satendra 
Published: January 2010

AbstractPeer‐assisted learning as de rigueur is reverberating in medical institutions around the world. Anatomy classroom activities are challenging and different, and the stressful environment of dissection rooms poses a greater challenge than what can be addressed through peer‐assisted learning. It is here that “near‐peer role modeling” is not only likely to be more useful, both to the students as well as their near‐peer teachers, but also holds the answer to the worsening faculty shortage in anatomy education. Anat Sci Educ 3:50–51, 2010. © 2010 American Association of Anatomists.
Unnatural Polyketide Analogues Selectively Target the HER Signaling Pathway in Human Breast Cancer Cells
Authors: Kwon Seok Joon , Kim Moon Il , Ku Bosung , Coulombel Lydie , Kim Jin‐Hwan , Shawky Joseph H. , Linhardt Robert J. , Dordick Jonathan S. 
Published: January 2010

AbstractReceptor tyrosine kinases are critical targets for the regulation of cell survival. Cancer patients with abnormal receptor tyrosine kinases (RTK) tend to have more aggressive disease with poor clinical outcomes. As a result, human epidermal growth factor receptor kinases, such as EGFR (HER1), HER2, and HER3, represent important therapeutic targets. Several plant polyphenols including the type III polyketide synthase products (genistein, curcumin, resveratrol, and epigallocatechin‐3‐galate) possess chemopreventive activity, primarily as a result of RTK inhibition. However, only a small fraction of the polyphenolic structural universe has been evaluated. Along these lines, we have developed an in vitro route to the synthesis and subsequent screening of unnatural polyketide analogues with N‐acetylcysteamine (SNAc) starter substrates and malonyl‐coenzyme A (CoA) and methylmalonyl‐CoA as extender substrates. The resulting polyketide analogues possessed a similar structural polyketide backbone (aromatic‐2‐pyrone) with variable side chains. Screening chalcone synthase (CHS) reaction products against BT‐474 cells resulted in identification of several trifluoromethylcinnamoyl‐based polyketides that showed strong suppression of the HER2‐associated PI3K/AKT signaling pathway, yet did not inhibit the growth of nontransformed MCF‐10A breast cells (IC50>100 μM). Specifically, 4‐trifluoromethylcinnamoyl pyrone (compound 2 e) was highly potent (IC50<200 nM) among the test compounds toward proliferation of several breast cancer cell lines. This breadth of activity likely stems from the ability of compound 2 e to inhibit the phosphorylation of HER1, HER2, and HER3. Therefore, these polyketide analogues might prove to be useful drug candidates for potential breast cancer therapy.
ChemInform Abstract: Matrix Infrared Spectroscopic and Computational Investigation of Late Lanthanide Metal Hydride Species MHx(H2)y (M: Tb—Lu, x = 1‐4, y = 0‐3).
Authors: Wang Xuefeng , Andrews Lester , Infante Ivan , Gagliardi Laura 
Published: January 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Magnetic Transitions in the Gd5Si4‐xPx (x = 0.5, 0.75, 1.25) Phases. Magnetocaloric Effect of the Gd5Si2.75P1.25
Authors: Svitlyk Volodymyr , Mozharivskyj Yurij 
Published: January 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis and Characterization of Eu‐Doped Hydroxyapatite Through a Microwave Assisted Microemulsion Process.
Authors: Yang Chun , Yang Piaoping , Wang Wenxin , Gai Shili , Wang Jun , Zhang Milin , Lin Jun 
Published: January 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Crystal Growth of Ln3GaO6 (Ln: Nd, Sm, Eu and Gd): Structural and Optical Properties.
Authors: Zeier Wolfgang G. , Roof Irina P. , Smith Mark D. , zur Loye Hans‐Conrad 
Published: January 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis, Characterization and Magnetic Properties of Complex Oxides Ln2Mn2/3Re4/3O7 (Ln: Er, Y) and Y2Zn2/3Re4/3O7.
Authors: Bazuev G. V. , Chupakhina T. I. , Korolyov A. V. 
Published: January 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: One‐Pot Desymmetrization of meso‐1,2‐Hydrocarbon Diols Through Acylation and Oxidation.
Authors: Mueller Christian E. , Zell Daniela , Schreiner Peter R. 
Published: January 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: 2‐(Phenylseleno)‐1,4‐dioxane as a Convenient Reagent for the Selective Protection of Alcohols as 1,4‐Dioxan‐2‐yl Ethers.
Authors: Temperini Andrea , Terlizzi Raffaella , Testaferri Lorenzo , Tiecco Marcello 
Published: January 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Palladium Complexes with Abnormal N‐Heterocyclic Carbene Ligands Derived from 1,2,3‐Triazolium Ions and Their Application in Suzuki Coupling.
Authors: Karthikeyan Thandavamurthy , Sankararaman Sethuraman 
Published: January 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Lewis‐Acid‐Catalyzed Reactions of Bis(4‐alkoxyphenyl)methanol with (Diarylmethylene)‐ and (Dialkylmethylene)cyclopropanes.
Authors: Yao Liang‐Feng , Shi Min 
Published: January 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Modular Synthesis of 1H‐Indenes, Dihydro‐s‐indacene, and Diindenoindacene — A Carbon‐Bridged p‐Phenylenevinylene Congener.
Authors: Zhu Xiaozhang , Mitsui Chikahiko , Tsuji Hayato , Nakamura Eiichi 
Published: January 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Pd‐Catalyzed Cross‐Coupling of Functionalized Organozinc Reagents with Thiomethyl‐Substituted Heterocycles.
Authors: Metzger Albrecht , Melzig Laurin , Deshpotopoulou Christina , Knochel Paul 
Published: January 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis of 3,3‐ and 4,4‐Alkyl‐phenyl‐substituted Pyrrolidin‐2‐one Derivatives.
Authors: Kulig K. , Ignasik M. , Malawska B. 
Published: January 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: The Synthesis of Polysubstituted Pyrroles via the Coupling of Phenyliodonium Ylides and Enamine Esters.
Authors: Wang Jun‐Yan , Wang Xian‐Pei , Yu Zheng‐Sen , Yu Wei 
Published: January 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: An Asymmetric Hetero‐Claisen Approach to 3‐Alkyl‐3‐aryloxindoles.
Authors: Duguet Nicolas , Slawin Alexandra M. Z. , Smith Andrew D. 
Published: January 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: CuCN‐Mediated O‐Alkylation of N,N‐Dimethylformamide with Alkyl Halides.
Authors: Thirumamagal B. T. S. , Narayanasamy Sureshbabu 
Published: January 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Catalyst‐Free Aldol Condensation of Ketones and Isatins under Mild Reaction Conditions in DMF with Molecular Sieves 4 Å as Additive.
Authors: Chen Wen‐Bing , Liao Yu‐Hua , Du Xi‐Lin , Zhang Xiao‐Mei , Yuan Wei‐Cheng 
Published: January 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Construction of Nitrogen Heterocycles Bearing an Aminomethyl Group by Copper‐Catalyzed Domino Three‐Component Coupling—Cyclization.
Authors: Ohta Yusuke , Chiba Hiroaki , Oishi Shinya , Fujii Nobutaka , Ohno Hiroaki 
Published: January 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: New Thiazoline—Oxazoline Ligands and Their Application in the Asymmetric Friedel—Crafts Reaction.
Authors: McKeon Sean C. , Mueller‐Bunz Helge , Guiry Patrick J. 
Published: January 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Indole 3‐Alkylation/Vinylation under Catalysis of the Guanidium Ionic Liquids.
Authors: Rad‐Moghadam Kurosh , Sharifi‐Kiasaraie Masoumeh 
Published: January 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: A New Synthesis of Benzo[f]isoindole‐4,9‐diones by Radical Alkylation and Bromomethylation of 1,4‐Naphthoquinones.
Authors: Deblander Jurgen , Van Aeken Sam , Jacobs Jan , De Kimpe Norbert , Tehrani Kourosch Abbaspour 
Published: January 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Open Vessel Mode Microwave‐Assisted Synthesis of 2‐Oxazolines from Carboxylic Acids.
Authors: Sharma Rishi , Vadivel Subramaniah K. , Duclos Richard I. Jr. , Makriyannis Alexandros 
Published: January 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Stereoselective Synthesis of 2,6‐cis‐Tetrahydropyrans Through a Tandem Allylic Oxidation/Oxa‐Michael Reaction Promoted by the gem‐Disubstituent Effect: Synthesis of (+)‐Neopeltolide Macrolactone.
Authors: Kim Hyoungsu , Park Yangho , Hong Jiyong 
Published: January 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: A Revisit to the Hantzsch Reaction: Unexpected Products Beyond 1,4‐Dihydropyridines.
Authors: Shen Li , Cao Song , Wu Jingjing , Zhang Jian , Li Hui , Liu Nianjin , Qian Xuhong 
Published: January 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Exploring Catalyst and Solvent Effects in the Multicomponent Synthesis of Pyridine‐3,5‐dicarbonitriles.
Authors: Guo Kai , Thompson Mark J. , Chen Beining 
Published: January 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Ruthenium‐Catalyzed Oxidative Homo‐Coupling of 2‐Arylpyridines.
Authors: Guo Xiangyu , Deng Guojun , Li Chao‐Jun 
Published: January 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: A Highly Efficient Pd—C Catalytic Hydrogenation of Pyridine Nucleus under Mild Conditions.
Authors: Cheng Chuanjie , Xu Jimin , Zhu Rui , Xing Lixin , Wang Xinyan , Hu Yuefei 
Published: January 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.