bluuebunny/crossref_metadata_2025_split huggingface dataset:
Minocycline in the eradication of Helicobacter pylori infection: A systematic review and meta-analysis
Authors: Zhou Kai , Li Cai-Ling , Zhang Hua , Suo Bao-Jun , Zhang Yu-Xin , Ren Xin-Lu , Wang Yu-Xin , Mi Chang-Min , Ma Ling-Ling , Zhou Li-Ya , Tian Xue-Li , Song Zhi-Qiang 
Published: April 2024

BACKGROUND
Difficulty in obtaining tetracycline, increased adverse reactions, and relatively complicated medication methods have limited the clinical application of the classic bismuth quadruple therapy. Therefore, the search for new alternative drugs has become one of the research hotspots. In recent years, minocycline, as a semisynthetic tetracycline, has demonstrated good potential for eradicating Helicobacter pylori (H. pylori ) infection, but the systematic evaluation of its role remains lacking.
AIM
To explore the efficacy, safety, and compliance of minocycline in eradicating H. pylori infection.
METHODS
We comprehensively retrieved the electronic databases of PubMed, Embase, Web of Science, China National Knowledge Infrastructure, SinoMed, and Wanfang database as of October 30, 2023, and finally included 22 research reports on H. pylori eradication with minocycline-containing regimens as per the inclusion and exclusion criteria. The eradication rates of H. pylori were calculated using a fixed or a random effect model, and the heterogeneity and publication bias of the studies were measured.
RESULTS
The single-arm meta-analysis revealed that the minocycline-containing regimens achieved good overall H. pylori eradication rates, reaching 82.3% [95% confidence interval (CI): 79.7%-85.1%] in the intention-to-treat analysis and 90.0% (95%CI: 87.7%-92.4%) in the per-protocol analysis. The overall safety and compliance of the minocycline-containing regimens were good, demonstrating an overall incidence of adverse reactions of 36.5% (95%CI: 31.5%-42.2%). Further by traditional meta-analysis, the results showed that the minocycline-containing regimens were not statistically different from other commonly used eradication regimens in eradication rate and incidence of adverse effects. Most of the adverse reactions were mild to moderate and well-tolerated, and dizziness was relatively prominent in the minocycline-containing regimens (16%).
CONCLUSION
The minocycline-containing regimens demonstrated good efficacy, safety, and compliance in H. pylori eradication. Minocycline has good potential to replace tetracycline for eradicating H. pylori infection.
The ZTF Source Classification Project. III. A Catalog of Variable
Sources
Authors: Healy Brian F. , Coughlin Michael W. , Mahabal Ashish A. , Jegou du Laz Theophile , Drake Andrew , Graham Matthew J. , Hillenbrand Lynne A. , van Roestel Jan , Szkody Paula , Zielske LeighAnna , Guiga Mohammed , Hassan Muhammad Yusuf , Hughes Jill L. , Nir Guy , Parikh Saagar , Park Sungmin , Purohit Palak , Rebbapragada Umaa , Reed Draco , Warshofsky Daniel , Wold Avery , Bloom Joshua S. , Masci Frank J. , Riddle Reed , Smith Roger 
Published: April 2024

Abstract
The classification of variable objects provides insight into a wide variety of
astrophysics ranging from stellar interiors to galactic nuclei. The Zwicky
Transient Facility (ZTF) provides time-series observations that record the
variability of more than a billion sources. The scale of these data necessitates
automated approaches to make a thorough analysis. Building on previous work,
this paper reports the results of the ZTF Source Classification Project
(SCoPe), which trains neural network and XGBoost
(XGB) machine-learning (ML) algorithms to perform dichotomous classification of
variable ZTF sources using a manually constructed training set containing
170,632 light curves. We find that several classifiers achieve high precision
and recall scores, suggesting the reliability of their predictions for
209,991,147 light curves across 77 ZTF fields. We also identify the most
important features for XGB classification and compare the performance of the two
ML algorithms, finding a pattern of higher precision among XGB classifiers. The
resulting classification catalog is available to the public, and the software
developed for SCoPe is open source and adaptable to
future time-domain surveys.
Blasting off with NASA’s Neurodiversity Network
Authors: Hellman Hannah , Cominsky Lynn 
Published: April 2024

Abstract
NASA’s Neurodiversity Network (N3) is a five-year program that is funded as part of NASA’s Science Activation Network. N3's main goal is to provide a pathway to NASA participation and Science, Technology, Engineering, and Mathematics (STEM) employment for neurodiverse learners, with a focus on those on the autism spectrum. Through the N3 program, we are enabling STEM education for a segment of the population that is significantly underserved through a process in which existing NASA education resources are redesigned with significant input from autistic learners and their instructors. The co-design process occurs primarily in informal environments, including high school summer programs, and camps and activity sessions for middle school students sponsored by the New York Hall of Science. N3 also offers a mentored summer internship program for at least ten neurodiverse high school students each year. Mentoring is provided by NASA Subject Matter Experts, individuals who collectively possess expertise that spans NASA’s Science Mission Directorate.
Dual-band, Multi-aperture Polarization Measurements of β Pictoris
Authors: Cotton Daniel V. , Marshall Jonathan P. , Bailey Jeremy , Kedziora-Chudczer Lucyna , Bott Kimberly 
Published: April 2024

Abstract
We present high precision, dual-band aperture polarimetry of the β Pictoris debris disk. The polarization is aperture dependent, increasing from 5″ to 19″ and peaking, after interstellar subtraction at around 230–240 ppm in both

g
′

and

r
′

bands; the polarization vector is oriented perpendicular to the disk major-axis. By simple calculations, lower limits are placed on the polarization of scattered light interior to 200 au. The observations and calculations are consistent with prior spatially resolved polarimetric measurements of the disk that probe greater angular separations, and models for the interior developed from them.
Alterações ortográficas em escolares dos anos finais do ensino fundamental: uma categorização centrada em aspectos fonológicos
Authors: Castro Pâmela Oliveira de , Simioni Taíse 
Published: April 2024

O presente artigo tem como objetivo geral apresentar um diagnóstico de alterações ortográficas produzidas por alunos dos anos finais do ensino fundamental. Os objetivos específicos são identificar as alterações ortográficas nas produções escritas de alunos dos anos finais do ensino fundamental; categorizar as alterações ortográficas analisando-as sob aspectos fonológicos; observar quais alterações são mais frequentes nos anos finais do ensino fundamental. Para tal, são analisadas produções textuais escritas de alunos do 7º ao 9º ano de uma escola pública municipal de Bagé (RS). Para a elaboração da produção textual, os participantes da pesquisa, em um primeiro momento, leram um conto de terror e, em um segundo momento, recriaram o conto por escrito, alterando seu final. Foram identificadas as seguintes categorias de alterações ortográficas: alteração decorrente de múltiplas representações do fonema /s/; alteração decorrente de hipercorreção; alteração por omissão de coda; alteração por omissão de núcleo e coda; alteração decorrente da representação de falsos ditongos; alteração decorrente de múltiplas representações do fonema /ʃ/; alteração decorrente de etimologia. Os resultados mostram que a alteração ortográfica mais frequente envolveu as múltiplas representações do fonema /s/, embora, dentro desta categoria, a maioria das alterações não possa ser justificada pela arbitrariedade do sistema alfabético. Tais resultados evidenciam a importância da formação em fonologia e fonética para os professores da Educação Básica, a fim de que possam, a partir de um diagnóstico bem realizado, propor uma intervenção adequada. Embora tenhamos consciência de que a escrita não se resume à ortografia, não podemos negar que ela é um de seus elementos constitutivos que merece a devida atenção no contexto escolar.
Direitos autorais e Estratégias de tokenização no contexto das ICTs públicas: uso dos NFTs para proteção de ativos de propriedade Intelectual no IFBA de Vitória da Conquista
Authors: Dias Edmilson Silva Dias Silva , De Souza André Luis Rocha 
Published: April 2024

A pesquisa teve por objetivo descortinar e apresentar as oportunidades trazidas pelas NFTs, inerentes ao direito autoral, que podem ser exploradas pelos pesquisadores do IFBA/Campus de Vitória da Conquista. Foi realizada uma pesquisa bibliográfica, com análise documental com abordagem qualitativa descritiva. Foram coletados dados secundários de produção científica do IFBA/Vitória da Conquista, cujo objetivo foi compreender os tipos de produções intelectuais e, a partir disso, ancorado no referencial teórico da pesquisa, desenvolver as oportunidades de aplicação dos NFTs na proteção dos ativos objeto de direitos autorais. Por fim, pode-se concluir que os NFTs apresentam potencial tecnológico que pode ser analisado como forma de melhorar a proteção dos produtos intelectuais produzidos pelos pesquisadores no âmbito das ICTs pública, em particular, do IFBA de Vitória da Conquista. Contudo, os desafios passam por regulamentação, desenvolvimento de padrões de processos e sistema de gestão.
Can FDG-PET assess the response to chemotherapy and predict tissue necrosis in osteosarcoma and Ewing sarcoma?
Authors: Andreani Lorenzo , Ipponi Edoardo , Ruinato Alfio Damiano , Lupi Tommaso , Di Sacco Federico , Volterrani Duccio , Coccoli Luca , Capanna Rodolfo 
Published: April 2024

Introduction: Osteosarcoma (OS) and Ewing sarcoma (ES) represent the pediatric population’s most common malignant bone tumors. 18-Fluorodeoxyglucose positron emission tomography has been shown to be effective in both the diagnostic and staging phases of cancer treatment. In recent years, some studies have also explored the possibility that FDG-PET could have a prognostic role.
Aim: Our research aimed to evaluate if maximum standardized uptake value (SUVmax) variations after chemotherapy could be correlated with tissue necrosis and be linked with patients’ survival rates.
Materials and methods: This observational retrospective study included all cases treated for skeletal OS or ES in our institution between 2006 and 2018. We recorded patients’ SUVmax values before and after chemotherapy, the necrosis grade (for those who received surgery), and survivorship. Forty-one cases (17 OS and 24 ES) were included. Among the 36 cases that received surgery, 15 were responders, and 20 were non-responders.
Results: Our data suggested a statistically significant correlation between tumor necrosis and differential SUVmax after neoadjuvant treatment (p=0.007). In particular, cases with differential SUVmax higher than 4.7 or a variation higher than 63% had better oncological outcomes.
Conclusion: Our study testifies to the effectiveness of FDG-PET in predicting tissue necrosis on ES and OS, thereby representing a promising prognostic factor.
Jean-Jacques Becker et l’historiographie franco-allemande de la Grande Guerre
Authors: Krumeich Gerd 
Published: April 2024

Cette contribution montre que l’un des apports essentiels de Jean-Jacques Becker à l’historiographie de la Grande Guerre a été de l’avoir envisagée dans une perspective résolument comparative et européenne. Gerd Krumeich explique comment a été concrètement mise en œuvre cette « Histoire franco-allemande de la Grande Guerre », par la confrontation des points de vue et par la discussion, ainsi que par le pilotage de projets de recherches de grande ampleur.
Le potentiel du design thinking pour les politiques publiques : Développer les capacités créatives pour co-construire la ville inclusive avec les personnes âgées
Authors: Castro-Gonçalves Luciana , Josion-Portail Margaret , Zadra-Veil Cathy 
Published: April 2024

L’adaptation des villes au vieillissement constitue un défi majeur pour les politiques publiques bottom-up . Dans ce cadre, cette recherche s’intéresse aux adaptations des méthodes de design thinking (DT) pour permettre la participation des citoyens âgés aux dispositifs de co-construction des innovations urbaines. L’analyse de trois ateliers de créativité montre comment les facteurs liés à la préparation des ateliers (appui sur des acteurs tiers, adoption d’une configuration intergénérationnelle, sensibilisation des participants âgés quant au rôle qu’ils peuvent jouer dans la génération de solutions) et à l’atteinte des finalités du processus créatif participent au développement des capacités créatives des personnes âgées. Les résultats sont discutés sous l’angle des apports à la littérature sur le DT et sur la participation des publics vulnérables au processus créatif.	Codes JEL : R580, H750, O360, O350
Institutions américaines et démocratie
Authors: Zoller Élisabeth 
Published: April 2024

Les prochaines élections présidentielles de novembre 2024 seront un test pour les institutions américaines. Conçues par les constituants de 1787 selon les principes de la philosophie des Lumières écossaises, leur idée de base est que la politique peut être traitée comme une science soumise à des lois. Leur objet est d’éviter l’arrivée au pouvoir d’un Donald Trump en neutralisant les atteintes à la démocratie qu’un homme imprévisible tel que lui peut commettre. Mais seront-elles à la hauteur des espoirs qu’elles font naître ?
BHLHE40 Regulates Myeloid Cell Polarization through IL-10–Dependent and –Independent Mechanisms
Authors: Hendrix Skyler V , Mreyoud Yassin , McNehlan Michael E , Smirnov Asya , Chavez Sthefany M , Hie Brian , Chamberland Megan M , Bradstreet Tara R , Webber Ashlee M , Kreamalmeyer Darren , Taneja Reshma , Bryson Bryan D , Edelson Brian T , Stallings Christina L 
Published: April 2024

Abstract
Better understanding of the host responses to Mycobacterium tuberculosis infections is required to prevent tuberculosis and develop new therapeutic interventions. The host transcription factor BHLHE40 is essential for controlling M. tuberculosis infection, in part by repressing Il10 expression, where excess IL-10 contributes to the early susceptibility of Bhlhe40−/− mice to M. tuberculosis infection. Deletion of Bhlhe40 in lung macrophages and dendritic cells is sufficient to increase the susceptibility of mice to M. tuberculosis infection, but how BHLHE40 impacts macrophage and dendritic cell responses to M. tuberculosis is unknown. In this study, we report that BHLHE40 is required in myeloid cells exposed to GM-CSF, an abundant cytokine in the lung, to promote the expression of genes associated with a proinflammatory state and better control of M. tuberculosis infection. Loss of Bhlhe40 expression in murine bone marrow–derived myeloid cells cultured in the presence of GM-CSF results in lower levels of proinflammatory associated signaling molecules IL-1β, IL-6, IL-12, TNF-α, inducible NO synthase, IL-2, KC, and RANTES, as well as higher levels of the anti-inflammatory–associated molecules MCP-1 and IL-10 following exposure to heat-killed M. tuberculosis. Deletion of Il10 in Bhlhe40−/− myeloid cells restored some, but not all, proinflammatory signals, demonstrating that BHLHE40 promotes proinflammatory responses via both IL-10–dependent and –independent mechanisms. In addition, we show that macrophages and neutrophils within the lungs of M. tuberculosis–infected Bhlhe40−/− mice exhibit defects in inducible NO synthase production compared with infected wild-type mice, supporting that BHLHE40 promotes proinflammatory responses in innate immune cells, which may contribute to the essential role for BHLHE40 during M. tuberculosis infection in vivo.
Psychiatric Referrals in a Tertiary Care Hospital in North India: A Retrospective Study
Authors: Bhardwaj Akansha , Gupta Dimple , Prakash Rashmi , Jose Nimmi A. 
Published: April 2024

Background and Aim:
There is high prevalence of mental disorders in specialist treatment seekers across specialties. Still, psychiatry referral rates have been found to be very low. A physician refers a patient to psychiatric services for reasons like known case of mental disorder, physical symptoms without adequate explanation, or if the physician feels inadequate in dealing with psychological symptoms. A multi disciplinary approach should be encouraged for the management of such patients, facilitating early recognition and management of psychiatric problems. The aim is to study the sociodemographic variables of psychiatric referrals, reasons and diagnostic categories of psychiatric referrals, and the distribution of psychiatric diagnoses according to reasons and sources of referrals.

Materials and Methods:
A retrospective hospital based study was conducted in the Department of Psychiatry, Hamdard Institute of Medical Sciences and Research, New Delhi, by analyzing the recorded data of referrals to the Psychiatry Department from various other specialties from January 2019 to March 2020. All referred patients were evaluated by a Psychiatrist (MD Psychiatry) and the diagnosis was made as per the International Statistical Classification of Diseases 10 criteria. The data obtained were analyzed using descriptive statistical methods.

Results:
This study included 315 psychiatric referrals. The mean age and standard deviation of the entire sample were 37.75 ± 17.63. The referral rate was minimum from January to March 2020. The highest number of referrals was from Medicine Department (66.3%). Among those, the most common diagnoses were that of alcohol dependence (27%). The most common overall reason for referral was substance use (26.2%). The most common psychiatric diagnosis was alcohol dependence (24%). Hypertension was the most common physical comorbidity. The most common diagnosis for known case of psychiatric illness and follow ups were psychotic disorders (27.3% and 26.3%).

Conclusion:
The findings of this study give us insight that consultation liaison psychiatry should focus on early recognition and wholesome management of psychiatric disorders in patients with physical illness through consultation psychiatry services in general hospital settings.
Mucormycosis Associated with Global Coronavirus Disease-19 Pandemic: A Study of Fungal Profile from a Tertiary Health-care Center
Authors: Purohit Snigdha , Mourya Kavita , Pathan Nazneen , Agarwal Sunita , Vyas Vithika , Vyas Aruna 
Published: April 2024

Background and Aim:
In this era of the coronavirus disease (COVID) pandemic, new health issues appear quickly and cause an outbreak in India. Here, we focus on invasive fungal infections (IFA), namely mucormycosis, aspergillosis, and candidiasis. Hence, in this article, we focus on conventional techniques for early diagnosis of fungus to help clinicians start empirical treatment for the patient and take necessary steps thereby.

Materials and Methods:
This observational study was conducted for 1 month, from May 2021 to June 2021, on 200 patients admitted to our mucormycosis ward. Samples were first examined microscopically using potassium hydroxide (KOH) wet mounts followed by culture on sabouraud dextrose agar and the gross appearance of the growth was observed. Further identification of species was achieved through the use of lactophenol cotton blue mounts and slide culture technique.

Results:
Out of 200 patients, 65.5% were male and 34.5% female. We divided these patients into three age groups, i.e., 20–30 years (15%), 40–60 years (54%), and 60–80 years (31%). Seventy-four percent of patients presented with a history of diabetes mellitus, 50% had a history of steroids taken in their past, and 48% had a history of oxygen therapy taken at the time of COVID-19 positivity (52%) samples positive for mucormycosis. Forty-one percent were KOH-positive for Mucorales and 35.5% were culture positive. The most commonly isolated fungus was Rhizopus, followed by Mucor,
Lichthemia,
Aspergillus
spp.,
and Candida
spp.

Conclusion:
To improve test sensitivity and enable early diagnosis, other serum biomarkers such as galactomannan, beta-D-glucan, cryptococcal antigenemia, and blood quantitative polymerase chain reaction for Aspergillus or Mucorales should be implemented.
Effect of Russian Current in Motor Performance among Chronic Stroke Survivors: A Pilot Study
Authors: Joy Joshin , Ravichandran Hariharasudhan , Vavachan Noble , Nambiar Adwaid , Shetty Archana , Alexander Joseph Oliver Raj 
Published: April 2024

Background and Aim:
Stroke is a leading cause of permanent disability in developing nations. Motor impairment in stroke contributes to limitations in activities of daily life, participation in community, and overall quality of life. Recovery following stroke is challenged by poor lower-limb muscle performance interfering with balance, gait, and functional tasks.

Objective:
The objective of this study was to investigate the effect of Russian current over the quadriceps muscle in 10-m walk performance and Brunnstrom stages of lower-extremity recovery in chronic stroke survivors.

Materials and Methods:
The Institutional Review Board approval was obtained for this pilot study, and a total of 36 chronic stroke survivors were recruited from the outpatient department of Alva’s College of Physiotherapy and Research Center, Moodubidire, Karnataka. Consent was obtained from the voluntary participants, and they were randomly assigned to one of the two groups; intervention and the control groups. Participants in the intervention group received Russian current over the quadriceps muscle in addition to the conventional rehabilitation, whereas the control group participants received only conventional rehabilitation. The study duration was 6 weeks. The outcomes measured were 10-m walk test and Brunnstrom stages of lower-extremity recovery.

Results:
Statistical analysis was performed with SPSS statistical software. The Kolmogorov–Smirnov test was performed for normality. The paired t-test, within-group analysis, demonstrated a significant increase in the 10-m walk test (P < 002) and Brunnstrom stage of lower extremity (P < 0.043) for the intervention group. The independent t-test demonstrated a highly significant (P = 0.001) value for the intervention group than the control group.

Conclusion:
Statistical results conclude that Russian current is effective in improving 10-m walk performance and Brunnstrom stages of motor recovery of lower limb in chronic stroke survivors.