bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical and Radiological Outcomes of Two Implants with Different Prosthetic Interfaces and Neck Configurations: Randomized, Controlled, Split‐Mouth Clinical Trial
Authors: Pozzi Alessandro , Agliardi Enrico , Tallarico Marco , Barlattani Alberto 
Published: June 2012

ABSTRACTBackground: Peri‐implant bone loss seems to occur following implant placement/loading regardless of all the efforts to eliminate it. Several factors, including surgical trauma, biologic width establishment, lack of passive fit of the superstructures, implant‐abutment microgap, and occlusal overloading, may increase peri‐implant bone loss. Over the years, new interface designs were introduced and clinical studies suggest that internal conical connection and platform shifting may be advantageous for marginal bone preservation.Purpose: To compare clinical and radiological outcomes of two implant designs with different prosthetic interfaces and neck configurations in a randomized, controlled, split‐mouth clinical trial.Materials and Methods: Thirty‐four partially edentate patients randomly received at least one internal conical connection with back‐tapered collar and platform shifting design or external‐hexagon implants with flat‐to‐flat implant‐abutment interface. Primary end point was peri‐implant bone level changes at different time points, failures of implants and/or prosthesis, any complications, implant stability quotient (ISQ) values, and periodontal parameters.Results: No dropout occurred. Marginal bone changes were statistically significantly different with better results for the internal conical connection. No implants and prosthesis failures have been observed, yielding a cumulative survival rate of 100%. A high ISQ value was found for both implants, and no statistically significant difference was found for ISQ mean values between interventions at each time point (p > .05). All implants showed no bleeding on probing and a very slight amount of plaque at the 1‐year‐in‐function visit.Conclusions: Both implant designs investigated performed similarly in terms of failure rates, providing successful results up to 1 year after loading. The back‐tapered neck configuration with conical connection and built‐in platform shifting showed statistically lower marginal bone loss than straight neck configuration with flat‐to‐flat implant‐abutment interface and external‐hexagonal connection.
Teaching narrative writing using comics:Delainey andRasmussen, the creators ofBetty, share their composing strategies as rich literacy resources for elementary teachers
Authors: Nixon Rhonda 
Published: June 2012

AbstractThe author explores how comics texts and writing practices are rich literacy resources for educators. Few studies report on how teachers explore such texts and practices in their classrooms. The author examines how drawing improves students' narrative writing and presents findings from a 7‐month case study of Delainey and Rasmussen's collaborative composing routines. Delainey and Rasmussen are the creators of the daily syndicated comic strip, Betty, an internationally published family comic strip that has been in newspapers for 20 years. The author explores Delainey and Rasmussen's collaborative routines and composing practices and provides parallel suggestions for classroom work.
Messing about with metaphor: multimodal aspects to children's creative meaning making
Authors: Taylor Roberta 
Published: June 2012

AbstractChildren's classroom talk and the connections between talk and text are current concerns for teachers. A deeper understanding of what child communication entails can ensure greater pedagogic support for the processes involved in text production. This article reports on a research project using multimodal discourse analysis to investigate child‐to‐child interaction in class. This research sought to uncover what multimodal analysis can reveal about the collaborative and creative meaning making, which children employ in spontaneous classroom discourse. Creativity here is understood in terms of everyday creativity in language. Instantiations of video‐recorded classroom communication between children have been closely analysed using a framework based on a functional view of interaction, specifically the work of the textual meta‐function. Attention to cohesive devices of intertextual referencing, idiom and metaphor as well as repetition and reference through a multimodal lens has revealed the ways in which all modes work in an integrated ensemble to make meaning. Examples in this article of the ways in which children ‘mess about’ with multimodal semiotic resources, employing them intertextually in metaphorical meaning making, have been taken from a Year 5 mixed primary geography lesson on the water cycle.
Dynamic flux balance analysis of the metabolism of Saccharomyces cerevisiae during the shift from fully respirative or respirofermentative metabolic states to anaerobiosis
Authors: Jouhten Paula , Wiebe Marilyn , Penttilä Merja 
Published: June 2012

Dynamic flux balance analysis was utilized to simulate the metabolic behaviour of initially fully respirative and respirofermentative steady‐state cultures of Saccharomyces cerevisiae during sudden oxygen depletion. The hybrid model for the dynamic flux balance analysis included a stoichiometric genome‐scale metabolic model as a static part and dynamic equations for the uptake of glucose and the cessation of respirative metabolism. The yeast consensus genome‐scale metabolic model [Herrgård MJ et al. (2008) Nat Biotechnol26, 1155–1160; Dobson PD et al. (2010) BMC Syst Biol4, 145] was refined with respect to oxygen‐dependent energy metabolism and further modified to reflect S. cerevisiae anabolism in the absence of oxygen. Dynamic flux balance analysis captured well the essential features of the dynamic metabolic behaviour of S. cerevisiae during adaptation to anaerobiosis. Modelling and simulation enabled the identification of short time‐scale flux distribution dynamics under the transition to anaerobic metabolism, during which the specific growth rate was reduced, as well as longer time‐scale process dynamics when the specific growth rate recovered. Expression of the metabolic genes was set into the context of the identified dynamics. Metabolic gene expression responses associated with the specific growth rate and with the cessation of respirative metabolism were distinguished.
National Coroners Information System: A valuable source of lessons for emergency medicine
Authors: Curran Justin , McD Taylor David 
Published: June 2012

AbstractObjectiveTo interrogate the National Coroners Information System (NCIS) to determine the recurrent themes among coroners’ recommendations that aimed to increase the safety of ED care.MethodsThis was a retrospective analysis of NCIS closed cases, from Queensland, New South Wales, Tasmania, Victoria, Australian Capital Territory, South Australia and North Territory, entered since its inception in 2000. The keyword ‘emergency department’ returned 1645 cases, of which 180 were found to be relevant. The primary outcomes were the number and nature of cases where recommendations for improvements in ED care had been made and the recurrent themes of these recommendations that could inform education initiatives.ResultsOf the 180 cases, 108 (60.0%) were of deceased men and subject age ranged from 2 days to 91 years. The commonest causes of death were trauma (26.7%), infection (24.4%), cardiac events (15.0%) and poisoning (8.9%). No coronial recommendations were required in 19 cases. For the remainder, recommendation themes related to issues of risk management/medico‐legal, diagnostic/therapeutic error, education, documentation/communication and re‐presentation. The themes associated with the different doctor designations (consultant, registrar, resident/intern) were similar, although registrars and residents/interns tended towards more diagnostic/therapeutic errors. The themes associated with hospital type (referral, urban, regional/rural) were also similar. Although theme analysis is important, some individual cases were particularly instructive.ConclusionThe NCIS data theme analysis indentifies important high‐risk patients and presenting complaints. These should be incorporated into emergency physician training. EDs should review the coronial recommendations to ensure that, where possible, they have been adopted.
Prevalence of suicidality in asymptomatic adolescents in the paediatric emergency department and utility of a screening tool
Authors: Hopper Sandy M , Woo Jia Wei , Sharwood Lisa N , Babl Franz E , Long Elliot J 
Published: June 2012

AbstractObjectiveMany authorities recommend screening adolescents for risk of suicide. The ED is a potential setting for such screening. The aim of this study is to explore the use of the Risk of Suicide Questionnaire (RSQ) as a screening tool for suicidality in patients who come to the ED without mental health concerns and without recent mental health history. The Suicide Ideation Questionnaire (SIQ) was the comparison standard.MethodsA cross‐sectional convenience sample of overtly psychiatrically asymptomatic adolescents presenting to a large paediatric ED underwent both the RSQ and SIQ. Adolescents with positive screens underwent formal assessment by mental health practitioners.ResultsTwo hundred and one patients were identified and 110 consented to participate. One hundred participants completed both questionnaires. Twenty‐two per cent of participants had positive RSQ (95% CI 14–31%). No adolescent yielded a positive SIQ: prevalence of suicidality was 0.0% (95% CI 0.0–3.6%). No participant showed suicidal ideation on formal review. One question in the RSQ – ‘Has something very stressful happened to you in the past few weeks?’ – accounted for the majority of false positive screens.ConclusionThe prevalence of suicidal ideation in asymptomatic patients presenting to this paediatric ED is very low. Using this selection method, the RSQ could not be validated, but would be unlikely to be suitable for screening this low‐risk population with a high false positive rate.
Transport media for avulsed teeth: A review
Authors: Udoye Christopher I. , Jafarzadeh Hamid , Abbott Paul V. 
Published: June 2012

AbstractManagement protocols for avulsed teeth should include management of the pulp and periodontal ligament (PDL) cells in order to improve the long‐term prognosis and survival of these teeth. The use of an inappropriate transport or storage medium potentially increases the risk of PDL cell necrosis, which can result in ankylosis and replacement resorption of the tooth root. Considering the critical role of these media, an informed choice of a suitable medium is essential for a favourable outcome. The literature regarding transport media for avulsed teeth was reviewed using PubMed/MEDLINE up to February 2010. This review outlines the common storage media that are available and highlights their specific features or problems. Although HBSS, ViaSpan and Eagle's medium have great potential to maintain the PDL cells in a viable state after avulsion, the practicalities of using these solutions, the costs and the lack of ready availability to the general public make them less than ideal. Milk remains the most convenient, cheapest and readily available solution in most situations while also being capable of keeping PDL cells alive. Hence, milk remains the storage medium of choice for avulsed teeth that cannot be replanted immediately or very soon after the avulsion.
Exercise training, genetics and type 2 diabetes‐related phenotypes
Authors: Hagberg J. M. , Jenkins N. T. , Spangenburg E. 
Published: June 2012

AbstractType 2 diabetes mellitus (T2DM) is at virtually pandemic levels world‐wide. Diabetes has been referred to as ‘a geneticist's nightmare’. However, dramatic advances in our understanding of the genetics of T2DM have occurred in the past 5 years. While endurance exercise training and increased habitual physical activity levels have consistently been shown to improve or be associated with improved T2DM‐related phenotypes, there is substantial interindividual variation in these responses. There is some evidence that T2DM‐related phenotype responses to exercise training are heritable, indicating that they might have a genetic basis. Genome‐wide linkage studies have not identified specific chromosomal loci that could account for these differences, and no genome‐wide association studies have been performed relative to T2DM‐related phenotype responses to exercise training. From candidate gene studies, there are relatively strong and replicated data supporting a role for the PPARγ Pro12Ala variant in the interindividual differences in T2DM‐related phenotype responses to training. This is a potentially important candidate locus because it affects T2DM susceptibility, has high biological plausibility and is the target for the primary pharmaceutical method for treating T2DM. Is it time to conduct a hypothesis‐driven large‐scale exercise training intervention trial based on PPARγ Pro12Ala genotype with T2DM‐related phenotypes as the primary outcome measures, while also assessing potential mechanistic changes in skeletal muscle and adipose tissue? Or would it be more appropriate to propose a smaller trial to address the specific skeletal muscle and adipose tissue mechanisms affected by the interaction between the PPARγ Pro12Ala genotype and exercise training?
Retesting the Separability of China's Rural Households
Authors: Wu Cuirong , Xin Xian 
Published: June 2012

AbstractThis article retests the separability of China's rural households in light of growing doubt about the sustainability of high economic growth in China. If a household's production decisions are “separable” from the household's consumption decisions, generally this suggests there is no surplus labor. Many scholars aver that China's surplus rural labor has spurred rapid economic growth, but concerns have arisen as to whether China still has surplus labor available. We investigate this issue using rural household panel data from 1993 to 2009 The regression results confirm that households in rural China have progressed from being non‐separable to separable. The estimation results for both the entire country and regions reject the separability hypothesis before 2004 but fail to reject the hypothesis after 2004 (with the exception of the central region). These results suggest that China's surplus labor supply is dwindling, especially in the eastern and the western regions. The sustainability of China's high economic growth is questionable in the absence of a large reservoir of surplus rural labor.
Developing Social Citizenship? A Case Study of Education and Health Services in Yantian Village of Guangdong Province
Authors: Hu Biliang , Saich Tony 
Published: June 2012

AbstractSocial policy is an indispensable element of rule and China's current leadership has moved policy to a more inclusive system based on a notion of citizenship. The extension of social welfare provision is examined through a case study of education and health care in the South China village of Yantian. Yantian lies at the core of the Pearl River Delta, which has become a key link in the global reorganization of manufacturing and production. Consequently the village is home to some 80 000 migrant workers who complement the 3000 registered inhabitants. A study of education and health‐care provision reveals that in terms of equity, registered villagers enjoy significant advantages in seeking welfare resources. Although living in the same village, the two groups inhabit “different worlds.” However, provision, while selective, has become more inclusive. The present research suggests that “social citizenship” will precede “political citizenship.”
Rising Consumption of Animal Products in China and India: National and Global Implications
Authors: Fu Wenge , Gandhi Vasant P. , Cao Lijuan , Liu Hongbo , Zhou Zhangyue 
Published: June 2012

AbstractOver the past two decades, the consumption of animal products has increased rapidly in China and India, driven by rising income and large populations. Such strong demand for animal products could have substantial impacts on both their own and global food and feed demand and supply. This paper examines the nature of rising demand for animal products in China and India and discusses national and global implications.
Chinese Offshore RMB Currency and Bond Markets: The Role of Hong Kong
Authors: Fung Hung‐Gay , Yau Jot 
Published: June 2012

AbstractThis paper discusses the role of Hong Kong in China's grand scheme to build up the RMB as a global reserve currency. We highlight the economic importance of Hong Kong to China in terms of channeling foreign direct investment into China, some of which, in the future, will be denominated in the RMB. We discuss the development of China's RMB currency swap and deposit markets in Hong Kong. These offshore markets enable the RMB to trade freely, setting the stage for the RMB to become fully convertible and allowing market forces to play a role in pricing the value of the RMB, and help in the development of the RMB‐denominated bond (or dim sum bond) market in Hong Kong. Finally, we present evidence of the phenomenal growth of the dim sum bond market in Hong Kong, which can further enhance and strengthen the use of the RMB outside China.
MET Gain in Diffuse Astrocytomas is Associated with Poorer Outcome
Authors: Pierscianek Daniela , Kim Young‐Ho , Motomura Kazuya , Mittelbronn Michel , Paulus Werner , Brokinkel Benjamin , Keyvani Kathy , Wrede Karsten , Nakazato Yoichi , Tanaka Yuko , Mariani Luigi , Vital Anne , Sure Ulrich , Ohgaki Hiroko 
Published: June 2012

AbstractGlioblastoma may develop rapidly without evidence for precursor lesions (primary glioblastomas), or progress from diffuse or anaplastic astrocytomas (secondary glioblastomas). Despite having distinct genetic profiles, these glioblastoma subtypes have similar histological features. We hypothesized that the highly malignant phenotype of glioblastoma may be attributable to genetic alterations that are common to both glioblastoma subtypes. In the present study, we first searched for commonly (>35%) amplified genes in glioblastomas with IDH1 mutation (a hallmark of secondary glioblastoma) and those without IDH1 mutation (typical for primary glioblastoma) in data from The Cancer Genome Atlas (TCGA). A total of 25 genes were identified, of which 21 were located at 7q31‐34. We then screened 264 gliomas (70 glioblastomas, 112 diffuse astrocytomas, 82 oligodendrogliomas) for gain of the MET at 7q31.2 with quantitative polymerase chain reaction (PCR). MET gain was detected in primary glioblastomas (47%) and secondary glioblastomas (44%), suggesting that this genetic alteration plays a role in the pathogenesis of both glioblastoma subtypes. MET gain was also common in diffuse astrocytomas (38%), but less frequent in oligodendrogliomas (16%). MET gain in diffuse astrocytomas was associated with shorter survival (median, 43.0 vs. 70.7 months; P = 0.004), suggesting that MET gain is a useful prognostic marker for diffuse astrocytomas.
Antioxidant, Antihyperglycemic, and Antihyperlipidemic Effects of Coriandrum sativum Leaf and Stem in Alloxan‐Induced Diabetic Rats
Authors: Sreelatha S. , Inbavalli R. 
Published: June 2012

Abstract:  In India's indigenous system of medicine, Coriandrum sativum (CS), commonly used as a food ingredient, is claimed to be useful for various ailments. To establish its utility in diabetes mellitus, the present study evaluated the antidiabetic and antioxidant effects of CS in alloxan‐induced diabetic rats. The extracts were shown to contain bioactive compounds including phenolics, flavonoids, steroids, and tannins. The extracts of CS in alloxan‐induced diabetic rats were found to significantly lower blood glucose levels. Antidiabetic activity of the CS extracts was compared with the clinically available drug glibenclamide. The levels of serum total cholesterol, triglycerides, and low‐density lipoprotein cholesterol were lower in the extract‐treated group and high‐density lipoprotein cholesterol was higher than the diabetic control rats. The extracts of CS exhibited strong scavenging effect on 2, 2‐diphenyl‐2‐picrylhydrazyl free radical and inhibition of lipid peroxidation. The free radical scavenging effect of the extracts was comparable with that of the reference antioxidants. Furthermore, it also showed an improved antioxidant potential as evidenced by decreased lipid peroxidation and a significant increase in the activity of various antioxidant enzymes such as catalase, superoxide dismutase, and glutathione peroxidase in the liver of diabetic rats. These results indicate that the extracts could protect liver function and exhibited hypoglycemic, hypolipidemic, and antioxidant efficacies in the diabetic rats. These results support the use of this plant extract to manage diabetes mellitus.Practical Applications:  The leaves and stem of this plant Coriandrum sativum if used in cuisine would be a remedy for diabetes.
Evaluation is a Dynamic Process: Moving Beyond Dual System Models
Authors: Van Bavel Jay J. , Jenny Xiao Yi , Cunningham William A. 
Published: June 2012

AbstractOver the past few decades, dual attitude/process/system models have emerged as the dominant framework for understanding a wide range of psychological phenomena. Most of these models characterize the unconscious and conscious mind as being built from discrete processes or systems: one that is reflexive, automatic, fast, affective, associative, and primitive, and a second that is deliberative, controlled, slow, cognitive, propositional, and more uniquely human. Although these models serve as a useful heuristic for characterizing the human mind, recent developments in social and cognitive neuroscience suggest that the human evaluative system, like most of cognition, is widely distributed and highly dynamic. Integrating these advances with current attitude theories, we review how the recently proposed Iterative Reprocessing Model can account for apparent dual systems as well as discrepancies between traditional dual system models and recent research revealing the dynamic nature of evaluation. Furthermore, we describe important implications this dynamical system approach has for various social psychological domains.
Iron Homeostasis during Cystic Fibrosis Pulmonary Exacerbation
Authors: Gifford Alex H. , Moulton Lisa A. , Dorman Dana B. , Olbina Gordana , Westerman Mark , Parker H. Worth , Stanton Bruce A. , O’Toole George A. 
Published: June 2012

AbstractBackground: Hypoferremia is a marker of disease severity in cystic fibrosis (CF). The effect of systemic antibiotics on iron homeostasis during CF pulmonary exacerbation (CFPE) is unknown. Our central hypotheses were that, by the completion of treatment, serum iron would increase, serum concentrations of interleukin‐6 (IL‐6) and hepcidin‐25, two mediators of hypoferremia, would decrease, and sputum iron would decrease.Methods: Blood and sputum samples were collected from 12 subjects with moderate‐to‐severe CF (median percentage‐predicted forced expiratory volume in 1 second (FEV1%) = 29%; median weight = 56 kg) within 24 hours of starting and completing a course of systemic antibiotics.Results: After treatment, subjects showed median FEV1% and body weight improvements of 4.5% and 2.0 kg, respectively (p < 0.05). Median serum iron rose by 2.4 μmol/L (p < 0.05), but 75% of patients remained hypoferremic. Median serum IL‐6 and hepcidin‐25 levels fell by 12.1 pg/mL and 37.5 ng/mL, respectively (p < 0.05). Median serum erythropoietin (EPO) and hemoglobin levels were unaffected by treatment. We observed a trend toward lower sputum iron content after treatment.Conclusions: Hypoferremia is a salient characteristic of CFPE that improves with waning inflammation. Despite antibiotic treatment, many patients remain hypoferremic and anemic because of ineffective erythropoiesis. Clin Trans Sci 2012; Volume 5: 368–373