bluuebunny/crossref_metadata_2025_split huggingface dataset:
Chromosomes 4 and 8 implicated in a genome wide SNP linkage scan of 762 prostate cancer families collected by the ICPCG
Authors: Lu Lingyi , Cancel‐Tassin Geraldine , Valeri Antoine , Cussenot Olivier , Lange Ethan M. , Cooney Kathleen A. , Farnham James M. , Camp Nicola J. , Cannon‐Albright Lisa A. , Tammela Teuvo L.J. , Schleutker Johanna , Hoegel Josef , Herkommer Kathleen , Maier Christiane , Vogel Walther , Wiklund Fredrik , Emanuelsson Monica , Grönberg Henrik , Wiley Kathleen E. , Isaacs Sarah D. , Walsh Patrick C. , Helfand Brian T. , Kan Donghui , Catalona William J. , Stanford Janet L. , FitzGerald Liesel M. , Johanneson Bo , Deutsch Kerry , McIntosh Laura , Ostrander Elaine A. , Thibodeau Stephen N. , McDonnell Shannon K. , Hebbring Scott , Schaid Daniel J. , Whittemore Alice S. , Oakley‐Girvan Ingrid , Hsieh Chih‐Lin , Powell Isaac , Bailey‐Wilson Joan E. , Cropp Cheryl D. , Simpson Claire , Carpten John D. , Seminara Daniela , Zheng S. Lilly , Xu Jianfen , Giles Graham G. , Severi Gianluca , Hopper John L. , English Dallas R. , Foulkes William D. , Maehle Lovise , Moller Pal , Badzioch Michael D. , Edwards Steve , Guy Michelle , Eeles Ros , Easton Douglas , Isaacs William B. ,   International Consortium for Prostate Cancer Genetics
Published: July 2011

AbstractBACKGROUNDIn spite of intensive efforts, understanding of the genetic aspects of familial prostate cancer (PC) remains largely incomplete. In a previous microsatellite‐based linkage scan of 1,233 PC families, we identified suggestive evidence for linkage (i.e., LOD ≥ 1.86) at 5q12, 15q11, 17q21, 22q12, and two loci on 8p, with additional regions implicated in subsets of families defined by age at diagnosis, disease aggressiveness, or number of affected members.METHODSIn an attempt to replicate these findings and increase linkage resolution, we used the Illumina 6000 SNP linkage panel to perform a genome‐wide linkage scan of an independent set of 762 multiplex PC families, collected by 11 International Consortium for Prostate Cancer Genetics (ICPCG) groups.RESULTSOf the regions identified previously, modest evidence of replication was observed only on the short arm of chromosome 8, where HLOD scores of 1.63 and 3.60 were observed in the complete set of families and families with young average age at diagnosis, respectively. The most significant linkage signals found in the complete set of families were observed across a broad, 37 cM interval on 4q13–25, with LOD scores ranging from 2.02 to 2.62, increasing to 4.50 in families with older average age at diagnosis. In families with multiple cases presenting with more aggressive disease, LOD scores over 3.0 were observed at 8q24 in the vicinity of previously identified common PC risk variants, as well as MYC, an important gene in PC biology.CONCLUSIONSThese results will be useful in prioritizing future susceptibility gene discovery efforts in this common cancer. Prostate 72:410–426, 2012. © 2011 Wiley Periodicals, Inc.
JNK Inhibition by SP600125 Attenuates trans‐10, cis‐12 Conjugated Linoleic Acid‐Mediated Regulation of Inflammatory and Lipogenic Gene Expression
Authors: Martinez Kristina , Kennedy Arion , McIntosh Michael K. 
Published: July 2011

AbstractSupplementation with a mixture of trans‐10, cis‐12 (t10,c12) and cis‐9, trans‐11 (c9,t11) isomers of conjugated linoleic acid (CLA), or t10,c12 CLA alone, reduces body weight and fat deposition in animals and some humans. However, these anti‐obesity actions of t10,c12 CLA are routinely accompanied by increased markers of inflammation and insulin resistance. Thus, we examined the extent to which blocking c‐Jun NH2‐terminal kinase (JNK) signaling using the JNK inhibitor SP600125 attenuated markers of inflammation and insulin resistance in primary human adipocytes treated with t10,c12 CLA. SP600125 attenuated t10,c12 CLA‐mediated phosphorylation of cJun and increased protein levels of activating transcription factor (ATF) 3, two downstream targets of JNK. SP600125 attenuated t10,c12 CLA‐mediated induction of inflammatory genes, including interleukin (IL)‐6, IL‐8, IL‐1β, ATF3, monocyte chemoattractant protein (MCP)‐1, and cyclooxygenase‐2. Consistent with these data, SP600125 prevented t10,c12 CLA‐mediated secretion of IL‐8, IL‐6, and MCP‐1. SP600125 prevented t10,c12 CLA suppression of lipogenic genes including peroxisome proliferator activated receptor gamma, liver X receptor, sterol regulatory element binding protein, acetyl‐CoA carboxylase, and stearoyl‐CoA desaturase. Additionally, SP600125 blocked t10,c12 CLA‐mediated induction of suppressor of cytokine synthesis‐3 and suppression of adiponectin and insulin‐dependent glucose transporter 4 mRNA levels. Collectively, these data suggest that JNK signaling plays an important role in t10,c12 CLA‐mediated regulation of inflammatory and lipogenic gene expression in primary cultures of human adipocytes.
2‐Polyunsaturated Acyl Lysophosphatidylethanolamine Attenuates Inflammatory Response in Zymosan A‐Induced Peritonitis in Mice
Authors: Hung Nguyen Dang , Kim Mee Ree , Sok Dai‐Eun 
Published: July 2011

AbstractIn the present study, the anti‐inflammatory action of lysophosphatidylethanolamine (lysoPtdEtn), orally administered, in zymosan A‐induced peritonitis was examined. Oral administration of 2‐DHA‐lysoPtdEtn (ED50, ~111 μg/kg) or 2‐ARA‐lysoPtdEtn (ED50, 221 μg/kg) was found to inhibit the plasma leakage in mice treated with zymosan A. In support of this, 2‐polyunsaturated acyl‐lysoPtdEtn diminished the formation of LTC4, a lipid mediator responsible for vascular permeability. Next, 2‐DHA‐lysoPtdEtn (ED50, 110 μg/kg) or 2‐ARA‐lysoPtdEtn (ED50, 123 μg/kg) effectively inhibited the leukocyte extravasation into the peritoneum. Consistent with this, each polyunsaturated‐lysoPtdEtn diminished the formation of LTB4 and 12‐HETE, potent chemotactic factors. Additionally, the level of pro‐inflammatory mediator (IL‐1 β, IL‐6, TNF‐α or NO) was lowered remarkably in contrast to the augmentation of anti‐inflammatory interleukin IL‐10. Furthermore, 2‐(15‐HETE)‐lysoPtdEtn and 2‐(17‐HDHE)‐lysoPtdEtn, 15‐lipoxygenation product of 2‐ARA‐lysoPtdEtn and 2‐DHA‐lysoPtdEtn, respectively, were more potent than corresponding lysoPtdEtn, suggesting the action of 2‐acyl‐lysoPtdEtn might be expressed through 15‐lipoxygenation. In support of this, the formation of 15‐HETE and LXA4 was upgraded in accordance with an increasing dose of 2‐ARA‐lysoPtdEtn. Separately, anti‐inflammatory actions, 2‐polyunsaturated acyl‐lysoPtdEtns also drastically diminished leukocyte infiltration in a later phase of zymosan A‐induced peritonitis, indicating that these lipids also possess pro‐resolving activity. Taken together, it is suggested that polyunsaturated lysoPtdEtns and their lipoxygenation derivatives, could be classified as potent anti‐inflammatory lipids.
La chronique de la gynéco: Human papillomavirus et assistance médicale à la procréation: « Liaisons dangereuses » ou flirts sans lendemain ?
Authors: Seznec C. 
Published: July 2011

Résumé
Au début de ce XXIe siècle, il est nécessaire de s’interroger sur la coexistence des Human papillomavirus (HPV), virus quasi ubiquitaires, et des techniques d’assistance médicale à la procréation (AMP) non pas sous l’angle des résultats de l’AMP mais du risque potentiel encouru par les femmes de développer des lésions épithéliales du tractus génital suite à une transmission de certains de ces virus oncogènes lors des techniques d’AMP intraconjugale ou par tiers donneur.
Emergency physician point-of-care ultrasound in the diagnosis of sialolithiasis
Authors: Duprey K. , Bramante Robert M. , Cirilli Angela R. , Raio Christopher C. 
Published: July 2011

Abstract
Sialolithiasis is a relatively common diagnosis, with an uncertain etiology, that must be considered in patients presenting with a neck mass. Traditionally, invasive sialography was used to detect salivary stones. Currently, computed tomography has been the test of choice. Ultrasound presents an alternative, rapid, and safe imaging modality for the diagnosis of sialolithiasis. We report a case of sialolithiasis diagnosed by emergency physicians using point-of-care ultrasonography.
Effect of gonadal steroid hormones on formalin‐induced temporomandibular joint inflammation
Authors: Torres‐Chávez K.E. , Sanfins J.M. , Clemente‐Napimoga J.T. , Pelegrini‐Da‐Silva A. , Parada C.A. , Fischer L. , Tambeli C.H. 
Published: July 2011

AbstractWe have recently demonstrated that gonadal steroid hormones decrease formalin‐induced temporomandibular joint nociception in rats. Given that the attenuation of inflammation is a potential mechanism underlying this antinociceptive effect, we evaluated the effect of gonadal steroid hormones on formalin‐induced temporomandibular joint inflammation. Plasma extravasation, a major sign of acute inflammation, and neutrophil migration, an important event related to tissue injury, were evaluated. Formalin induced significantly lower temporomandibular joint plasma extravasation and neutrophil migration in proestrus females than in males and in diestrus females. Since estradiol serum level is high in proestrus females and low in diestrus females and in males, these findings suggest that the high physiological level of estradiol decreases temporomandibular joint inflammation. Estradiol but not progesterone administration in ovariectomized females significantly decreased formalin‐induced plasma extravasation and neutrophil migration, an effect that was blocked by the estrogen receptor antagonist ICI 182780. Plasma extravasation and neutrophil migration were not affected by orchiectomy, but testosterone or estradiol administration in orchidectomized males significantly decreased them. The androgen receptor antagonist flutamide blocked the anti‐inflammatory effect of testosterone while ICI 182780 blocked that of estradiol in males. Previous intravenous administration of a nonspecific selectin inhibitor significantly decreased formalin‐induced temporomandibular joint nociception and neutrophil migration in males, revealing a potent and positive correlation between temporomandibular joint nociception and inflammation. Taken together, these findings demonstrate a pronounced anti‐inflammatory effect of estradiol and testosterone in the temporomandibular joint region and suggest that this effect may mediate, at least in part, the antinociceptive effect of these hormones.
Arsenic speciation in biomedical sciences: Recent advances and applications
Authors: Hsu Keng‐Chang , Sun Chien‐Che , Huang Yeou‐Lih 
Published: July 2011

AbstractSpeciation analysis of trace elements is an important issue in biomedical and toxicological sciences because different elemental species have different effects on health and the environment. For humans, arsenic (As) is a toxic element; the toxicity of As compounds is highly dependent on its chemical form. Although inorganic As compounds are human carcinogens, organic arsenicals are relatively less toxic. This article deals with recent advances and applications of methods for As speciation in biomedical sciences, with emphasis on the specimens commonly encountered in biomedical laboratories.
Transcriptional modulation induced by ionizing radiation: p53 remains a central player
Authors: Rashi‐Elkeles Sharon , Elkon Ran , Shavit Seagull , Lerenthal Yaniv , Linhart Chaim , Kupershtein Ana , Amariglio Ninette , Rechavi Gideon , Shamir Ron , Shiloh Yosef 
Published: July 2011

AbstractThe cellular response to DNA damage is vital for maintaining genomic stability and preventing undue cell death or cancer formation. The DNA damage response (DDR), most robustly mobilized by double‐strand breaks (DSBs), rapidly activates an extensive signaling network that affects numerous cellular systems, leading to cell survival or programmed cell death. A major component of the DDR is the widespread modulation of gene expression. We analyzed together six datasets that probed transcriptional responses to ionizing radiation (IR) – our novel experimental data and 5 published datasets – to elucidate the scope of this response and identify its gene targets. According to the mRNA expression profiles we recorded from 5 cancerous and non‐cancerous human cell lines after exposure to 5 Gy of IR, most of the responses were cell line‐specific. Computational analysis identified significant enrichment for p53 target genes and cell cycle‐related pathways among groups of up‐regulated and down‐regulated genes, respectively. Computational promoter analysis of the six datasets disclosed that a statistically significant number of the induced genes contained p53 binding site signatures. p53‐mediated regulation had previously been documented for subsets of these gene groups, making our lists a source of novel potential p53 targets. Real‐time qPCR and chromatin immunoprecipitation (ChIP) assays validated the IR‐induced p53‐dependent induction and p53 binding to the respective promoters of 11 selected genes. Our results demonstrate the power of a combined computational and experimental approach to identify new transcriptional targets in the DNA damage response network.
Gesundheitsökonomischer Nutzen der betrieblichen Gesundheitsförderung
Authors: Ahrens Dieter , Goldgruber Judith 
Published: July 2011

Einleitung
Zur Beurteilung des wirtschaftlichen Nutzens der betrieblichen Gesundheitsförderung ist zunächst eine Betrachtung der Wirksamkeit der gesundheitsbezogenen Interventionen im Setting Betrieb erforderlich. Dieser Beitrag fasst den derzeitigen Stand zur Wirksamkeit dieser Maßnahmen zusammen und gibt einen Ausblick auf mögliche wirtschaftliche Nutzenpotenziale der Betrieblichen Gesundheitsförderung.
Messung psychischer Belastungen am Arbeitsplatz
Authors: Nübling Matthias 
Published: July 2011

Einleitung
Auf Grund gesetzlicher Verpflichtungen und wegen des starken Ansteigens der Arbeitsunfähigkeitstage und –fälle mit psychischen Diagnosen in den letzten 20 Jahren ist das Thema psychische Belastungen am Arbeitsplatz mehr und mehr in den Fokus von Wissenschaft und Praxis gerückt.
Die zwei führenden Theorien der letzten Jahrzehnte waren das job-strain-model (demand-control-support model, DCS) und das effort-reward imbalance model (ERI).
In jüngerer Zeit wurden Instrumente entwickelt, die durch eine breitere Palette der Aspekte versuchen, ein möglichst vollständiges Bild der psychosozialen Faktoren am Arbeitsplatz zu zeichnen- ein Beispiel hierfür ist der COPSOQ (Copenhagen Psychosocial Questionnaire). Es konnte gezeigt werden, dass diese zusätzlichen Aspekte auch einen höheren Varianzanteil in den Belastungsfolgen (outcomes) erklären können.
Da für die Bewertung der psychischen Belastungen keine cutoff-Werte existieren, ist im praktischen Einsatz solcher Verfahren im Rahmen der Gefährdungsbeurteilung die Verfügbarkeit von tätigkeitsspezifischen Referenzwerten für die Interpretation von Ergebnissen und die Ableitung von Präventionsmaßnahmen hilfreich bzw. notwendig.
Rückengerechte Arbeitsweisen in der Pflege – was wirkt?
Authors: Michaelis Martina 
Published: July 2011

Einleitung
Der Beitrag beschäftigt sich mit dem Stand evidenzbasierter Forschung zur Wirksamkeit von Maßnahmen, die die Prävention von Muskel- und Skeletterkrankungen (MSE) bei Pflegenden fokussieren. Effekte singulär durchgeführter Maßnahmen auf MSE scheinen aktuell entweder ungenügend, widersprüchlich oder nicht vorhanden. Für mehrdimensionale Programme ist der Wirksamkeitsgrad nachweislich besser. Es werden Defizite diskutiert, die bestimmend für die Wirksamkeitsbeurteilung einer arbeitsbezogenen Präventionsmaßnahme sind.
Umsetzung des Betrieblichen Eingliederungsmanagements: Praxisprobleme und Empfehlungen
Authors: Vater Gudrun 
Published: July 2011

EinleitungMenschen mit Behinderung oder gesundheitlicher Einschränkung sind in hohem Maße gefährdet, ihren Arbeitsplatz zu verlieren. Der Wiedereinstieg ins Erwerbsleben stellt für diese Personen eine kaum zu bewältigende Herausforderung dar. Vor diesem Hintergrund gewinnen präventive Ansätze der Beschäftigungssicherung immer mehr an Bedeutung. Mit der Einführung des Betrieblichen Eingliederungsmanagement § 84, 2 SGB IX (BEM) hat der Gesetzgeber im Jahr 2004 auf diese Situation reagiert.
The assessment of food security in homeless individuals: a comparison of the Food Security Survey Module and the Household Food Insecurity Access Scale
Authors: Holland Anna C , Kennedy Matthew C , Hwang Stephen W 
Published: July 2011

AbstractObjectiveTo compare the Household Food Insecurity Access Scale (HFIAS), the US Food Security Survey Module (US FSSM) and a modified version of the US FSSM in which references to buying food were changed to references to getting food, in terms of their classification of food security levels among homeless individuals, and to determine which of these instruments was most preferred by homeless individuals.DesignA cross-sectional survey.SettingRecruitment of participants took place at seven shelters and from three drop-in programmes that serve homeless individuals in Toronto, Canada.SubjectsFifty individuals who were ≥18 years of age, able to communicate in English and currently homeless.ResultsThe modified US FSSM assigned 20 % of participants to a lower ordinal food security category compared with the US FSSM, and only 8 % to a higher food security category. The HFIAS assigned 30 % of participants to a lower food security category compared with either the US FSSM or the modified US FSSM, and only 10–16 % of participants to a higher food security category. When asked to compare all three instruments, the majority of respondents (62 %) selected the HFIAS as the best instrument for people who are homeless.ConclusionsA majority of homeless individuals selected the HFIAS as the best food security instrument for people who are homeless. Our findings suggest that the HFIAS is a more appropriate instrument than the US FSSM for measuring food security in the homeless population.
The Influences of Body Size, Habitat Quality, and Competition on the Movement and Survival of Juvenile Coho Salmon during the Early Stages of Stream Recolonization
Authors: Pess G. R. , Kiffney P. M. , Liermann M. C. , Bennett T. R. , Anderson J. H. , Quinn T. P. 
Published: July 2011

AbstractUnderstanding the factors influencing the success of juvenile Pacific salmon Oncorhynchus spp. in newly colonized habitats is essential to their recovery in large areas across the West Coast of the United States and Canada. We studied biotic and abiotic factors associated with survival during the early stages of colonization and population establishment of juvenile coho salmon O. kisutch in Rock Creek, a tributary of the upper Cedar River in the Lake Washington basin of Puget Sound, Washington. The stream was occupied by resident fishes (e.g., rainbow trout O. mykiss, cutthroat trout O. clarkii, speckled dace Rhinichthys osculus, and several sculpins Cottus spp.), but adult coho salmon and other anadromous fishes had been excluded by a dam from 1901 until fish ladder installation in 2003. We defined logistic regression models and used an information‐theoretic approach to predict apparent survival with various combinations of individual fish condition, location competition, and local habitat quality. The best‐approximating models included measures of brood year, body size, habitat, and migration timing. Survival was positively associated with body size and habitat quality and negatively associated with competition. Survival from late summer to smolt migration varied among years (mean ± SD = 27 ± 11%) and was significantly higher within Rock Creek (73 ± 11%) than during seaward migration in the Cedar River and Lake Washington (38 ± 14%). Juvenile coho salmon established a population and outnumbered resident salmonid species by 40% in the lower 2 km of Rock Creek within 5 years of colonization. Overall, the results revealed the linkage between the colonization success of juvenile coho salmon and the biotic features and habitat quality in a newly accessible environment during the stream‐rearing phase of their life history.
Whatever happened to entitlement in the National Curriculum?
Authors: Willan Patrick T. 
Published: July 2011

ABSTRACTIn this article I recount the origins of the concept of entitlement in relation to the com‐ pulsory curriculum, particularly the government position (DES, 1987) as stated in the proposal for a National Curriculum. I suggest that the term ‘entitlement’ was then in clanger of being little more than a legitimating shibboleth, employed to lend authority to an educational programme that was substantially political rather than educational. With reference to my own doctoral research, and to subsequent National Curriculum developments, I observe that the passing of a decade has lent weight to this view, even as Sir Ron Dearing's major review (SCAA, 1994) continued to make various claims for entitlement being conveyed upon children.
Broadening the basis of assessment to prevent the narrowing of learning
Authors: James Mary , Gipps Caroline 
Published: July 2011

ABSTRACTThis article presents an argument for a reconsideration of the types of assessment promoted by national policy. It argues that education for the twenty‐first century should place emphasis on higher‐order skills and ‘deep learning’ while not neglecting basic skills. The evidence relating to the impact of assessment on learning is briefly reviewed, as is the current state of understanding about different types of learning. On this basis it is argued that the range of types of assessments used, both formally and informally, should be expanded to illuminate and support a wide spectrum of relevant learning, including both the learning of facts and skills, deeper understandings of concepts and principles and their application in unfamiliar contexts. The implications for policy and for the refocusing of national assessment in England are then discussed and an alternative framework is proposed.
Providing opportunities for active learning: assessing incidence and impact
Authors: Halsall Rob , Cockett Mike 
Published: July 2011

ABSTRACTAn active learning methodology has been advanced by a number of people as a means of promoting more meaningful and effective learning and has underpinned initiatives in schools such as TVEI. However, while there is an extensive literature concerning principles and pedagogy, there have been few attempts to assess the incidence of the provision of active learning opportunities or, indeed, to assess whether such learning has been effected. Two major attempts are reviewed prior to the presentation and discussion of new data which were gathered utilizing newly developed sets of indicators of the provision of active learning opportunities and of active learning itself. The article concludes with a discussion of the constraints on such provision and of the reasons why a renewed focus on active learning might be imminent.
Uncovering music in the National Curriculum ‐ a social semiotic approach to the title page
Authors: Bray Elizabeth 
Published: July 2011

ABSTRACTThis article embraces the notion that visual design, with or without accompanying text, has developed particular characteristics that encode messages between author and reader which often operate below a level of consciousness. As such, it accepts the premise put forward by Kress (1993) that all signs are motivated, rather than arbitrary, and draws heavily on the work of Kress and Van Leeuwen (1996) and other extensive literature in the field. The design subjected to this type of analysis or reading is the title page of Music in the National Curriculum published by the Department For Education in 1995. The article tries to show how the design alone represents a particular view of knowledge and a particular approach to curriculum design, which is then confirmed in the subsequent pages.