bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association between epidermal growth factor receptor–tyrosine kinase inhibitors and venous thromboembolism among older patients with advanced non–small cell lung cancer
Authors: Byun Joo‐Young , Aiyeolemi Ayobami , Qdaisat Aiham , Park Chanhyun 
Published: June 2024

AbstractBackgroundVenous thromboembolism (VTE) risk is higher among patients with non–small cell lung cancer (NSCLC) and specific subgroups, including the elderly, but little is known about the VTE risk of different generations of epidermal growth factor receptor–tyrosine kinase inhibitors (EGFR‐TKIs) and whether the risk differs by demographic characteristics. This study aims to compare the risk of VTE (deep venous thromboembolism [DVT]; pulmonary embolism [PE]) between a third‐generation EGFR‐TKI and first/second‐generation EGFR‐TKIs and stratify VTE risk by sex, age, and race/ethnicity in third‐generation EGFR‐TKI users.MethodsVia the 2006–2019 Surveillance, Epidemiology, and End Results–Medicare database, this retrospective cohort study included older patients (aged ≥65 years) with advanced NSCLC who initiated on a third‐generation EGFR‐TKI (n = 493) and first/second‐generation EGFR‐TKIs (n = 1036). We estimated the hazard ratio (HR) and its 95% confidence interval (95% CI) with the Cox proportional hazards model.ResultsA third‐generation EGFR‐TKI had a significantly higher VTE risk than first/second‐generation EGFR‐TKIs (HR, 1.26 [95% CI, 1.01–1.57]; p = .037), with an elevated risk in males (HR, 2.16 [95% CI, 1.47–3.19]; p < .001), patients aged ≥75 years (HR, 1.38 [95% CI, 1.04–1.83]; p = .026), and non‐Hispanic Whites (HR, 1.46 [95% CI, 1.10–1.95]; p = .010). Males consistently showed a significantly higher risk of DVT (HR, 2.49 [95% CI, 1.29–4.80]; p = .007) and PE (HR, 2.00 [95% CI, 1.29–3.11]; p = .002). A significantly higher risk of DVT (HR, 1.54 [95% CI, 1.00–2.37]; p = .050) and PE (HR, 1.47 [95% CI, 1.06–2.05]; p = .021) was shown in patients aged ≥75 years and non‐Hispanic Whites, respectively. Among third‐generation EGFR‐TKI users, non‐Hispanic Whites had a significantly higher risk of VTE (HR, 2.04 [95% CI, 1.03–4.02]; p = .041) and PE (HR, 2.88 [95% CI, 1.24–6.70]; p = .014) than non‐Hispanic Asian/Pacific Islanders.ConclusionsClose monitoring of VTE events in high‐risk patients is essential to promote early diagnosis and treatment.
Raman Spectral Analysis in the CHx‐Stretching Region as a Guiding Beacon for Non‐Targeted, Disruption‐Free Monitoring of Germination and Biofilm Formation in the Green Seaweed Ulva
Authors: Schultz Constanze , Zopf David , Holzinger Andreas , Silge Anja , Meyer‐Zedler Tobias , Schmitt Michael , Wichard Thomas , Popp Juergen 
Published: June 2024

AbstractRaman spectroscopy was used to study the complex interactions and morphogenesis of the green seaweed Ulva (Chlorophyta) and its associated bacteria under controlled conditions in a reductionist model system. Integrating multiple imaging techniques contributes to a more comprehensive understanding of these biological processes. Therefore, Raman spectroscopy was introduced as a non‐invasive, label‐free tool for examining chemical information of the tripartite community Ulva mutabilis‐Roseovarius sp.‐Maribacter sp. The study explored cell differentiation, cell wall protrusion, and bacterial‐macroalgae interactions of intact algal thalli. Using Raman spectroscopy, the analysis of the CHx‐stretching wavenumber region distinguished spatial regions in Ulva germination and cellular malformations under axenic conditions and upon inoculation with a specific bacterium in bipartite communities. The spectral information was used to guide in‐depth analyses within the fingerprint region and to identify substance classes such as proteins, lipids, and polysaccharides, including evidence for ulvan found in cell wall protrusions.
Vicinal diaryl pyrazole with tetrazole/urea scaffolds as selective angiotensin converting enzyme‐1/cyclooxygenase‐2 inhibitors: Design, synthesis, anti‐hypertensive, anti‐fibrotic, and anti‐inflammatory
Authors: Fadaly Wael A. A. , Elshaier Yaseen A. M. M. , Ali Fares E. M. , El‐Bahrawy Ali H. , Abdellatif Khaled R. A. , Nemr Mohamed T. M. 
Published: June 2024

AbstractAs a hybrid weapon, two novel series of pyrazoles, 16a‐f and 17a‐f, targeting both COX‐2 and ACE‐1‐N‐domain, were created and their anti‐inflammatory, anti‐hypertensive, and anti‐fibrotic properties were evaluated. In vitro, 17b and 17f showed COX‐2 selectivity (SI = 534.22 and 491.90, respectively) compared to celecoxib (SI = 326.66) and NF‐κB (IC50 1.87 and 2.03 μM, respectively). 17b (IC50 0.078 μM) and 17 f (IC50 0.094 μM) inhibited ACE‐1 comparable to perindopril (PER) (IC50 0.048 μM). In vivo, 17b decreased systolic blood pressure by 18.6%, 17b and 17f increased serum NO levels by 345.8%, and 183.2%, respectively, increased eNOS expression by 0.97 and 0.52 folds, respectively and reduced NF‐κB‐p65 and P38‐MAPK expression by −0.62, −0.22, −0.53, and −0.24 folds, respectively compared to
l‐NAME (−0.34, −0.45 folds decline in NF‐κB‐p65 and P38‐MAPK, respectively). 17b reduced ANG‐II expression which significantly reversed the cardiac histological changes induced by L‐NAME.
Oxymatrine attenuates sepsis‐induced inflammation and organ injury via inhibition of HMGB1/RAGE/NF‐κB signaling pathway
Authors: He Junbing , Qin Wanbing , Jiang Shusong , Lin Yao , Lin Yingying , Yang Ruoxuan , Xu Mingwei , Liu Qinghua 
Published: June 2024

AbstractSepsis is a life‐threatening organ dysfunction that endangers patient lives and is caused by an imbalance in the host defense against infection. Sepsis continues to be a significant cause of morbidity and mortality in critically sick patients. Oxymatrine (OMT), a quinolizidine alkaloid derived from the traditional Chinese herb Sophora flavescens Aiton, has been shown to have anti‐inflammatory effects on a number of inflammatory illnesses according to research. In this study, we aimed to evaluate the therapeutic effects of OMT on sepsis and explore the underlying mechanisms. We differentiated THP‐1 cells into THP‐1 macrophages and studied the anti‐inflammatory mechanism of OMT in a lipopolysaccharide (LPS)‐induced THP‐1 macrophage sepsis model. Activation of the receptor for advanced glycation end products (RAGE), as well as NF‐κB, was assessed by Western blot analysis and immunofluorescence staining. ELISA was used to measure the levels of inflammatory factors. We found that OMT significantly inhibited HMGB1‐mediated RAGE/NF‐κB activation and downstream inflammatory cytokine production in response to LPS stimulation. Finally, an in vivo experiment was performed on septic mice to further study the effect of OMT on injured organs. The animal experiments showed that OMT significantly inhibited HMGB1‐mediated RAGE/NF‐κB activation, protected against the inflammatory response and organ injury induced by CLP, and prolonged the survival rate of septic mice. Herein, we provide evidence that OMT exerts a significant therapeutic effect on sepsis by inhibiting the HMGB1/RAGE/NF‐κB signaling pathway.
An evolutionary case for plant rarity: Eucalyptus as a model system
Authors: Nytko Alivia G. , Senior John K. , Wooliver Rachel C. , O'Reilly‐Wapstra Julianne , Schweitzer Jennifer A. , Bailey Joseph K. 
Published: June 2024

AbstractSpecies rarity is a common phenomenon across global ecosystems that is becoming increasingly more common under climate change. Although species rarity is often considered to be a stochastic response to environmental and ecological constraints, we examined the hypothesis that plant rarity is a consequence of natural selection acting on performance traits that affect a species range size, habitat specificity, and population aggregation; three primary descriptors of rarity. Using a common garden of 25 species of Tasmanian Eucalyptus, we find that the rarest species have 70% lower biomass than common species. Although rare species demonstrate lower biomass, rare species allocated proportionally more biomass aboveground than common species. There is also a negative phylogenetic autocorrelation underlying the biomass of rare and common species, indicating that traits associated with rarity have diverged within subgenera as a result of environmental factors to reach different associated optima. In support of our hypothesis, we found significant positive relationships between species biomass, range size and habitat specificity, but not population aggregation. These results demonstrate repeated convergent evolution of the trait‐based determinants of rarity across the phylogeny in Tasmanian eucalypts. Furthermore, the phylogenetically driven patterns in biomass and biomass allocation seen in rare species may be representative of a larger plant strategy, not yet considered, but offering a mechanism as to how rare species continue to persist despite inherent constraints of small, specialized ranges and populations. These results suggest that if rarity can evolve and is related to plant traits such as biomass, rather than a random outcome of environmental constraints, we may need to revise conservation efforts in these and other rare species to reconsider the abiotic and biotic factors that underlie the distributions of rare plant species.
Markers of Fertility in Adolescents With Chronic Endocrinopathies at Transition From Paediatric to Adult Care
Authors: Choukair Daniela , Mittnacht Janna , Bettendorf Markus 
Published: June 2024

ABSTRACTObjectiveDuring the process of transition from paediatric to adult health care, counselling concerning fertility is an important issue and is based mainly on serum markers of gonadal function. Here, we analysed these markers in adolescents with various underlying endocrine diseases at the time of transition.MethodsAfter reaching near adult height and late puberty (girls: bone age [BA] ≥14 years, and boys: BA ≥16 years), we assessed stages of puberty according to Tanner and measured testes or ovarian volumes and serum markers of gonadal function (anti‐Mullerian hormone [AMH], inhibin B, 17β‐estradiol, testosterone).ResultsOne hundred and ten patients (56 females and 54 males) were included from May 2010 to March 2016 with multiple pituitary hormone deficiency (MPHD; n = 17), growth hormone deficiency (GHD; n = 35), Turner syndrome (TS; n = 27), short stature after being born small for gestational age (SGA; n = 20) and Klinefelter syndrome (KS; n = 11). Female and male adolescents exhibited mature secondary sexual characteristics. The levels of serum inhibin B and AMH were lower in TS and female MPHD than in GHD and SGA, each independently (p < 0.05). The levels of serum AMH were higher whereas serum inhibin B were lower in male MPHD and KS (p < 0.05). Ovary volumes were significantly smaller in patients with TS, and testicular volumes were smaller in patients with KS.ConclusionsAfter current established treatments with sex steroids, the development of secondary sexual characteristics was mature. However, impaired markers of fertility have been identified in patients with TS, KS and MPHD, reflecting gonadal dysgenesis in TS and KS, but gonadal immaturity in MPHD as gonadal gonadotropin stimulation is lacking throughout development. Consequently, in patients with MPHD, these markers cannot reliably predict individual fertility, which warrants consideration and incorporation in future treatment concepts.
Edible corn oil: A holistic exploration from processing to market dynamics
Authors: Boukid Fatma , Rosentrater Kurt A. 
Published: June 2024

AbstractCorn oil is a major agricultural commodity, and it is a staple in kitchens worldwide. This comprehensive review aims to provide a holistic understanding of corn oil processing, composition, nutritional benefits, properties, and market dynamics. The processing of corn oil poses challenges in achieving optimal extraction efficiency while addressing environmental concerns. Currently, hexane‐extracted corn oil dominates the market, with cold‐pressed corn oil being a niche product. Ongoing efforts within the industry focus on exploring alternative, environmentally friendly extraction methods such as critical CO2 and enzymatic‐assisted extraction. Corn oil is recognized for its rich composition in monounsaturated and polyunsaturated fats, tocopherol content, and potential antioxidant benefits. However, its high omega‐6 fatty acid content, while contributing to its stability, has raised discussions about its potential impact on inflammatory responses when consumed excessively. Due to its high smoke point, corn oil is suitable for high‐temperature cooking without compromising its neutral taste. Yet, its oxidation stability is lower compared to other commercial oils. Relying on oleic‐rich varieties or incorporating antioxidants could help enhance its stability and mitigate potential oxidative concerns. In the future, advancements in processing technologies promise to elevate the nutritional profile of corn oil, aligning it with the evolving preferences of health‐conscious consumers and addressing sustainability concerns.Practical Applications. This review provides crucial insights into the processing, nutritional profile, and market dynamics of corn oil, benefiting researchers and industry professionals. By understanding the challenges and advancements in extraction methods, researchers can develop more sustainable and efficient processes. The detailed analysis of corn oil's composition and functionality provides practical solutions for improving product shelf‐life and quality. This comprehensive review supports the optimization of corn oil production and utilization and aids in positioning corn oil as a competitive and versatile option in the global vegetable oil market.
Binding of Linear Anions and Formation of Anion Encapsulated Dimeric Capsular Assembly by Cis‐5,15‐bis(3,5‐trifluoromethylphenyl)calix[4]pyrrole
Authors: Patra Ashoke Kumar , Roy Anik , Gomila Rosa M. , Kundu Somenath , Srimayee Soumya , Halder Dibakar , Saha Rajat , Lee Chang‐Hee , Hossain Maidul , Frontera Antonio , Manna Debasis , Saha Indrajit 
Published: June 2024

AbstractCis‐5,15‐bis(3,5‐trifluoromethylphenyl)calix[4]pyrrole (1) forms stable 1/1 complexes with linear anions such as N3−, SCN− and NCO‐ with the highest affinity for NCO− anion in acetonitrile solution. Crystallization of receptor 1 with TBASCN and (TMA)2SO4 resulted in the formation of dimeric capsular assembly, {(TMA)2[12 ⋅ (SCN)2]}, in which two thiocyanate anions are encapsulated. On the other hand, 1 ⋅ OCN(TMA) and 1 ⋅ N3(TMA) complexes form one dimensional columnar structure in the solid state.
Stereoselective Synthesis of Key Skeleton of Mohangic Acids A‐E
Authors: Mondal Joyanta , Guchhait Sandip , Sharma Himangshu , Goswami Rajib Kumar 
Published: June 2024

AbstractThe key skeleton that could allow to access structurally intriguing mohangic acids A−E has been synthesized in stereoselective manner. The salient features of this synthesis include Evans syn‐aldol reaction to construct the C‐11 and C‐12 centers, HWE olefination to construct C14−C15 bond, Evans asymmetric methylation to install C‐14 center and Crimmins acetate aldol to generate C‐15 center whereas Wittig and Takai olefinations to prepare the C8–C9 & C6–C7 alkenes, respectively, and Heck reaction to couple C1–C5 & C6–C17 segments of the molecules. The developed route is highly modular and useful for accessing diverse natural product like molecules for future investigations.
Study of composite polymer degradation for high pressure hydrogen vessel by machine learning approach
Authors: Kadri K. , Kallel A. , Guerard G. , Abdallah A. Ben , Ballut S. , Fitoussi J. , Shirinbayan M. 
Published: June 2024

AbstractThe aim of this article is to study the degradation of a composite material under static pressure. The high pressure condition is similar to the one encountered inside hydrogen tanks. Damage modeling was used to evaluate the behavior of hydrogen tanks to high pressure. A practical approach, coupling a finite element method (FEM) simulation and machine learning (ML) algorithm, is suggested. The representative volume element (RVE) was used in association with a choice of a behavior law and a damage law as an input data. Algorithms for ML classification such as K‐nearest neighbors (k‐NN) and a special k‐NN with a dynamic time warping metric were used. The hierarchical clustering through dendrograms visualizations allowed to exhibit the impact of composite parameters in relation to fiber, matrix properties and fiber volume fraction on the strain degradation under external static pressure. Continuing this, the optimum RVE which shows a low degradation value will be exhibited.
Microvascular reconstruction of midface osteoradionecrosis
Authors: Sweeny Larissa , Konuthula Neeraja , Jackson Ryan , Wax Mark K. , Curry Joseph M. , Yang Sara , Amin Dev , Kane Anne C. , Cannady Steve B. , Tasche Kendall , DiLeo Michael , Lander Daniel , Kejner Alexandra E. , Pipkorn Patrik 
Published: June 2024

AbstractBackgroundHead and neck osteoradionecrosis (ORN) of the midface requiring free flap (FF) reconstruction is uncommon. This multi‐institutional study was designed to review outcomes for this rare patient population.MethodsRetrospective multi‐institutional review of FF reconstruction for midface ORN (2005–2022; n = 54).ResultsThe FF survival rate was 87% (n = 54). Patients were less likely to be tolerating a regular diet at 3 months postoperative if they had a preoperative history of prior head and surgery (80% vs. 95%; p = 0.02), a pathologic fracture (50% vs. 90%; p = 0.04), exposed bone intraorally (43% vs. 94%; p = 0.002), or a fistula (67% vs. 96%; p = 0.03). Mean albumin was higher in patients whose FF survived (3.6 ± 0.5 vs. 2.7 ± 1.4; p = 0.03). Patients with low prealbumin were more likely to undergo a hematoma evacuation (27% vs. 0%; p = 0.02).ConclusionIn this series of midface ORN requiring FF reconstruction preoperative nutritional status impacted postoperative complications. Preoperative occurrence of a fistula, pathologic fracture, and intraoral bone exposure correlated with decreased tolerance of a regular diet following reconstruction.
Convective heat loss from a modified solar cavity receiver with vertical plate fins: An experimental assessment
Authors: Mobasheri‐Shiri Hamideh , Yazdanipour Tahereh , Razzaghi Kiyanoosh 
Published: June 2024

AbstractExperimental investigations have been conducted to study the convective heat transfer from a cylindrical solar cavity receiver with vertical fins. The experiments were performed under varying surface heat flux levels and at seven inclination angles, ranging from −90° (upward facing) to +90° (downward facing) at 30° intervals. The impact of fins on the heat transfer process was studied by conducting experiments in two scenarios, namely, finned and unfinned cavities. The findings of the study showed that with an increase in cavity inclination, the magnitude of convective heat loss decreased in both finned and unfinned cavities, while the cavity surface temperature increased. At +90° inclination, the convective heat loss and Nusselt number were observed to have the lowest value, while the surface temperature had the highest value. For a downward‐facing cavity, the fins reduced convective heat loss, leading to an increase in cavity surface temperature. The finned cavity performed better for a vertically downward‐facing inclination (+90°) as it had a contribution of only 11% for convection heat loss compared with the unfinned cavity, which had a contribution of 21% for the same. Furthermore, an empirical model was developed based on the experimental results for the Nusselt number, which correlates experimental data with an error margin of ±15%. This model can be used to predict the Nusselt number for different inclination angles and surface heat flux levels. The presence of vertical fins in the cavity was found to be effective in reducing convective heat loss, especially for downward‐facing cavities. Understanding the influence of fin and cavity inclination on convective heat transfer can lead to enhanced efficiency and performance of solar receivers, thereby increasing the overall energy output of the system.
Quantitative susceptibility mapping as an early neuroimaging biomarker for amyotrophic lateral sclerosis: A review
Authors: Mohammadi Sana , Ghaderi Sadegh , Fatehi Farzad 
Published: June 2024

AbstractQuantitative susceptibility mapping (QSM) is an advanced post‐processing technique in magnetic resonance imaging that offers precise measurements of tissue magnetic susceptibility with impressive spatial resolution and sensitivity. This review examines the potential of QSM as a biomarker for early detection and monitoring of amyotrophic lateral sclerosis (ALS). Since 2015, studies have consistently reported increased QSM values in the motor regions of individuals with ALS, indicating significant iron deposition. Iron accumulation is associated with dysfunction of the upper motor neurons and faster disease progression. Notably, increased QSM values were also observed in the critical subcortical areas responsible for motor function and cognitive control. However, standardizing optimized protocols, including background field removal algorithms, phase unwrapping approaches, and methods for final susceptibility map reconstruction, has the potential to enhance the consistency and reliability of QSM as an ALS biomarker. Overall, the current body of evidence strongly supports QSM in detecting iron dysregulation associated with neurodegeneration in both motor and extra‐motor regions in ALS. Furthermore, QSM's remarkable sensitivity to early pathological iron changes and its high specificity in distinguishing ALS positions make it a promising diagnostic and progression‐tracking biomarker.
Comparison of synchronous reinforcement and accumulated reinforcement for increasing on‐task behavior in preschoolers
Authors: Diaz de Villegas Sara C. , Dozier Claudia L. , Kanaman Ky C. , Leslie Stacha C. , Kamlowsky Marissa E. 
Published: June 2024

AbstractIn synchronous‐reinforcement schedules, the duration of behavior directly controls the duration of reinforcement on a moment‐to‐moment basis. We replicated and extended Diaz de Villegas et al. (2020) by comparing the effects of synchronous reinforcement with two accumulated‐reinforcement schedules for increasing on‐task behavior for seven preschoolers. One accumulated schedule was the same as the one used in Diaz de Villegas et al. and did not include tokens, whereas the other accumulated schedule included the delivery of tokens within session. Furthermore, we assessed preference for the three reinforcement schedules. The results showed that synchronous reinforcement was effective for increasing on‐task behavior for all seven participants. Furthermore, it was most effective for increasing on‐task behavior for three out of seven participants and preferred by all participants. For some participants, other schedules were also similarly effective. The results are discussed with respect to implications for application.