bluuebunny/crossref_metadata_2025_split huggingface dataset:
Teledermatology: an Evidence Map of Systematic Reviews
Authors: Chow Aloysius , Smith Helen Elizabeth , Car Lorainne Tudor , Kong Jing Wen , Choo Kay Wee , Aw Angeline Ai Ling , Wong Marie Ann Mae En , Apfelbacher Christian 
Published: May 2024

Abstract

Background: Although the number of teledermatology studies is increasing, not all variables have been researched in equal depth, so there remains a lack of robust evidence for some teledermatology initiatives. This review describes the landscape of teledermatology research and identifies knowledge gaps and research needs.
Methods: Our evidence map was conducted according to the Campbell Collaboration checklist for evidence and gap maps. Eight databases were searched: CINAHL, Embase, PubMed, Scopus, Web of Science, Cochrane Library, JBI Database of Systematic Reviews and Implementation Reports, and OpenGray. From 909 records, 14 systematic reviews published between 2004 and 2023 were included. Our analysis focused on the systematic reviews’ characteristics, dermatological conditions studied, rate of overlap and quality assessment of primary studies reviewed, and main findings reported.
Results: Teledermatology was reportedly comparable with clinic dermatology and generally accepted by patients as a mode of care delivery for dermatological conditions. However, there are concerns about privacy, communication, completeness of information transmitted, familiarity with the technology, and technical problems. Healthcare professionals were generally satisfied with teledermatology, but found telemedicine consultations longer than face-to-face consultations, and less confident in asynchronous teledermatology than conventional consultations. Teledermatology was reportedly more cost-effective than clinic dermatology; especially considering the distance travelled by patients, referral volume to teledermatology, and clinic dermatology costs. Although patients and providers are satisfied with teledermatology, face-to-face dermatology has higher diagnostic and management accuracy. Teledermatology was also used for training medical professionals. Regarding the validity and reliability of teledermatology outcome measures, no significant discussions were found.
Conclusions: COVID-19 spotlighted telemedicine in clinical care, and we must ensure telemedicine continually improves with robust research. Further research is necessary for establishing a standardised outcome set, enhancing accuracy, concordance, cost-effectiveness, and safety, comparing teledermatology with non-dermatologist care, examining its effectiveness in non-Western low and middle-income countries, and incorporating patient involvement for improved study design.
Systematic review registration: The review was registered at https://www.researchregistry.com/ (Unique Identifying Number: reviewregistry878).
Predictors of Response to CDK4/6i Retrial After Prior CDK4/6i Failure in ER+ Metastatic Breast Cancer
Authors: Jhaveri komal , Mai Nicholas , Anjos Carlos Henrique dos , Razavi Pedram , Safonov Anton , Patil Sujata , Chen Yuan , Drago Joshua , Modi Shanu , Bromberg Jacqueline , Dang Chau , Liu Dazhi , Norton Larry , Robson Mark , Chandarlapaty Sarat 
Published: May 2024

Abstract

After disease progression on endocrine therapy (ET) plus a CDK4/6 inhibitor, there is no standardized sequence for subsequent treatment lines for estrogen receptor positive (ER+) metastatic breast cancer (MBC). CDK4/6i retrial as a treatment strategy is commonplace in modern clinical practice; however, the available prospective data investigating this strategy have had inconclusive results. To frame this data in a real-world context, we performed a retrospective analysis assessing the efficacy of CDK4/6is in 195 patients who had previous exposure to CDK4/6i in a prior treatment line at our institution. Among patients who had stopped a CDK4/6i due to toxicity, CDK4/6i retrial either immediately after with a different CDK4/6i or in a further treatment line with the same initial CDK4/6i was both safe and effective, with a median time to treatment failure (TTF) of 10.1 months (95%CI, 4.8-16.9). For patients whose disease progressed on a prior CDK4/6i, we demonstrated comparable median TTFs for patients rechallenged with the same CDK4/6i (4.3 months, 95%CI 3.2-5.5) and with a different CDK4/6i (4.7 months, 95%CI 3.7-6.0) when compared to the recent PACE, PALMIRA, and MAINTAIN trials. Exploratory genomic analysis suggested that the presence of mutations known to confer CDK4/6i resistance, such as TP53 mutations, CDK4 amplifications, and RB1 or FAT1 loss of function mutations may be molecular biomarkers predictive of CDK4/6i retrial failure.
Expression Patterns and Prognostic Model Construction of the Major Histocompatibility Complex-Related Gene Granzyme B in Oral Squamous Cell Carcinoma
Authors: Zhang Hongrong , Zhou Xue , Li Jingyi , Zhang Wanyue , Sun Zheyi , Wang Weihong 
Published: May 2024

Abstract

Oral squamous cell carcinoma (OSCC) accounts for 90% of malignant tumors in the oral and maxillofacial region, known for its high metastatic potential and poor prognosis. This study aims to investigate Major Histocompatibility Complex(MHC) related genes' involvement in OSCC, offering new insights for immunotherapy. We identified differentially expressed genes associated with MHC in OSCC, analyzed copy number variations and pathways enrichment, and developed a prognostic model using Cox regression analysis on patient data. Our model proved to be an independent prognostic indicator, effectively predicting patients' prognosis and showcasing its efficacy in estimating 5-year survival rates. Immunoinfiltration analysis highlighted Granzyme B (GZMB) as a key gene significantly correlated with immune cells, showing varied expression across tumor stages. Additionally, we characterized OSCC tissue grading, finding higher GZMB protein expression in well-differentiated compared to moderately differentiated tissues, both exceeding levels in normal tissues. Our findings suggest the developed prognostic model could serve as a reliable biomarker for OSCC prognosis, emphasizing the crucial role of GZMB in tumor progression.
Craniocaudal cyclic load improve risk assessment of lumbar pedicle screw loosening：finite element analysis based on computer tomography
Authors: Jiang Chenyu , ouyang Hanqiang , Li Yali , Ni Ming , Jin Dan , Zhang Yan , Jiang liang , Yuan Huishu 
Published: May 2024

Abstract

Background:
Screw loosening remains a prominent complication for osteoporotic patients with pedicle screw fixation surgeries, yet with limited risk assessment approach. The aim of this study was to investigate influence of craniocaudal cyclic load on pedicle screw fixation strength by computed tomography (CT) based finite element analysis (FEA) and we examined predict ability in pedicle screw loosening (PSL).
Methods:
12 clinical PSL cases (7 men, 5 women) and 12 age- and sex-matched controls were enrolled for CT based FEA. Simple axial pullout load and axial pullout load with preset craniocaudal cyclic load were applied to each model respectively, and the ultimate pullout force under both conditions is calculated as the fixed strength and compared. Besides, HU values of the vertebral body trabeculae and screw trajectory were measured as an assessment of osteoporosis. The ultimate pullout force and HU value were compared between PSL and controls cases.
Results
The cyclic load remarkably reduce the pullout force of pedicle screws (906.2 ± 180.2 N vs. 729.3 ± 172.3 N, p<0.0001) by CT based FEA. No significant difference between the PSL and the control group in the simple axial pull-out force and HU values of the vertebral body. But the pullout force with preset cyclic load (639.2 ± 169.4 N vs. 819.4 ± 125.1 N, p = 0.072) and the HU value of the screw trajectory (177.5 ± 43.8 vs. 217.2 ± 29.6, p = 0.016) in the PSL group is significantly lower than that in the control group. Area under receiver operating characteristic curve (ROC) revealed pullout force with preset cyclic load slightly better predicted PSL than HU value of the screw trajectory (AUC = 0.798 vs. 0.750).
Conclusions
The craniocaudal cyclic load significantly reduces the screw fixation strength. HU value of screw trajectory and pullout force with preset cyclic load by CT based FEA are helpful for the clinical prediction of PSL.
Plasma free hemoglobin is associated with LDH, AST, total bilirubin, reticulocyte count, and the hemolysis score in patients with sickle cell anemia
Authors: Liu Angela , Jacobs-McFarlane Charleen , Sebastiani Paola , Glassberg Jeffrey , McCuskee Sarah , Curtis Susanna 
Published: May 2024

Abstract

Plasma free hemoglobin (PFH) is a direct biomarker for hemolysis that has been associated with clinical complications such as pulmonary hypertension and death in patients with sickle cell disease (SCD). We sought to characterize the relationship between PFH and more clinically available hemolytic markers including lactate dehydrogenase (LDH), aspartate aminotransferase (AST), bilirubin, reticulocyte percentage and to derive a composite hemolysis score derived from principal component analysis (PCA) of these biomarkers. In 68 adult patients (median age 31 years old, IQR 25-39) with HbSS or HbSβ0-thalassemia enrolled in the IMPROVE II study, median PFH was elevated at 21.9 mg/dL (IQR 9.9-44.9 mg/dL). Using Pearson correlation analysis, PFH had a stronger relationship to LDH (R=0.699), AST (R=0.587), and total bilirubin (R=0.475), compared to reticulocyte count (R=0.316). The hemolysis score was significantly associated with PFH (R=0.677). When compared with other laboratory measures, PFH correlated with hemoglobin (R= -0.275) and HbS (R=0.277),but did not correlate with white blood cell count (WBC) or HbF. The hemolysis score was significantly associated with WBC (R=0.307), hemoglobin (R = -0.393), HbF (R=- 0.424), and HbS (R=0.423). This study confirms that the conventional hemolytic biomarkers LDH, AST, bilirubin, and reticulocyte percentage correlate with PFH. Additionally, the hemolysis score is a valid tool to measure hemolysis and that it may be a marker of global hemolysis as opposed to PFH, which quantifies intravascular hemolysis. Further studies will be needed to elucidate the role of PFH and intravascular hemolysis in the development of clinical complications of sickle cell disease.
Effects of high-intensity interval training on physical morphology, cardiopulmonary function, and metabolic indicators in older adults: A PRISMA-based systematic review and meta-analysis
Authors: #Men Jie , Zhao Chengrui , Xiang Chenmin , Zhu Guoyu , Yu Zhengyang , Wang Pengbo , Wu Simin , Zhang Yuxi , Li Yishan , Wang Liuliu , Gong Xueyan , Yang Xiang , Zou Shuangling , Ma Jia , Cui Chenglong , Li Hao , Ma Xuedi , Wu Wenjie , Wang Yaoming 
Published: May 2024

Abstract

Background
Despite the growing attention towards the efficacy of high-intensity interval training (HIIT) on elderly health, a consensus regarding the pleiotropic effects of HIIT in this population is yet to be reached. Previous studies have predominantly focused on specific outcomes or particular groups, lacking comprehensive analysis.
Objective
We aimed to conduct a systematic evaluation of the impact of HIIT on body composition, cardiopulmonary function, and metabolic parameters in older adults.
Methods
The databases searched included PubMed, Web of Science, Cochrane Library, Scopus, WanFang, and other relevant sources from the inception of the database until July 2023. We supplemented the randomized controlled trials (RCTs) and retrieved relevant meta-analyses, and found that 5 highly relevant non-RCTs were also included in the supplement to study the effects of high-intensity interval training (HIIT) on body composition, cardiopulmonary function and metabolic parameters in the elderly.
Result
A total of 92 studies, including 87 RCTs and 5 non-RCTs, involving a sample size of 4355 elderly individuals were included in the analysis. The meta-analysis results demonstrated that HIIT significantly improved body mass index (BMI) [MD: -0.38kg m-2,P = 0.01], body fat percentage (BF%) [MD༚-1.38%, P<0.00001], maximal oxygen uptake (VO2max) [MD:2.23ml min− 1kg− 1, P<0.00001], maximal heart rate (HRmax) [MD:2.84 beats min− 1, P = 0.02], and high-density lipoprotein levels (HDL) [MD:0.04mmol L− 1, P = 0.0007] among the elderly population. However, no significant improvements were observed for systolic blood pressure (SBP) [MD: -0.28mmHg, P = 0.75], resting heart rate (HRrest) [MD: -0.95time min− 1, P = 0.24], triglycerides (TG) [MD: -0.04mmol L− 1, P = 0.27], low-density lipoprotein (LDL) [MD: -0.05mmol L− 1, P = 0.23]. Sensitivity analysis found that HIIT significantly improved waist circumference (WC) [MD: -2.13cm, P = 0.04], diastolic blood pressure (DBO) [MD: -0.96 mmHg, P = 0.03], respiratory exchange rate (RER) [MD: 0.01, P = 0.04], total cholesterol (TC) [MD: 0.15 mmol L− 1, P = 0.009], fasting plasma glucose (FPG) [MD: -0.23 mmol L− 1, P = 0.04]in the elderly, but the results lacked robustness.
Conclusions
The results of this study provide further support for HIIT to improve the physical health of the elderly, especially in terms of body shape and cardiopulmonary function, more importantly, provide a reference for HIIT in clinical practice and family health management of the elderly and the development of HIIT guidelines.
Clinical evolution of patients with Intracerebral hemorrhage in relation to the achievement of intensive blood pressure lowering target
Authors: Vázquez-Justes Daniel , Paul-Arias Miriam 
Published: May 2024

Abstract

Introduction: Spontaneous intracerebral hemorrhage (ICH) is one of the most disabling forms of stroke. Intensive lowering of blood pressure (BP) has been postulated as one of the therapies that can improve functional outcomes. However, this intensive reduction is not always achieved.
We aimed to study the differences between patients in whom intensive BP lowering was achieved during the first 24 h after admission and those in whom this BP lowering was not possible.
Methods: We retrospectively reviewed medical charts to obtain information on BP management during the first 24 hours. Our protocol establishes that intensive BP lowering below 140 mmHg of SBP should be pursued.
Results: A total of 210 patients were included. In 103, an intensive target BP was achieved. This group of patients had a lower initial NIHSS score and better clinical evolution, with less early neurological deterioration, fewer requirements of antihypertensive treatment, less necessity for surgical evacuation, less withdrawal of life-sustaining therapies (WLST), and lower mortality at three months (all p < 0,05). However, in the multivariable analysis, BP target achievement was not related to mortality, and only NIHSS score (OR 1,010 [CI 95% 1,007 − 1,203], p = 0,034) and WLST (OR 10,816 [CI 95%: 2,768 − 42,270], p < 0,001) remained related.
Conclusions: In our study, patients with intensive BP lowering had better clinical outcomes and lower mortality at 3 months. However, this observation could be related to a better clinical situation at the onset of stroke and fewer requirements for antihypertensive treatment. The initial NIHSS score and adoption of WLST were independently associated with mortality at 3 months.
A randomized controlled trial exploring the effect of placement versus nonplacement of a drainage tube around the cervical anastomosis in McKeown esophagectomy
Authors: Oshikiri Taro , Goto Hironobu , Kato Takashi , Takiguchi Gosuke , Koterazawa Yasufumi , Kanaji Shingo , Yamashita Kimihiro , Matsuda Takeru , Nakamura Tetsu , Murakami Sae , Kakeji Yoshihiro , Hasegawa Hiroshi 
Published: May 2024

Abstract

Purpose
Esophageal cancer has an overall five-year survival rate of < 20%. The McKeown esophagectomy is invasive and carries a high risk of anastomotic leakage. Robust prospective outcome data comparing non-placement versus placement of a cervical drainage tube during McKeown esophagectomy are lacking. This study aimed to evaluate whether the placement of a cervical drainage tube is useful.
Methods
In this randomized controlled, noninferiority trial, 106 patients with histologically proven, surgically resectable esophageal carcinoma were randomized to either placement or non-placement of a cervical drainage tube. The primary outcome was the percentage of Clavien–Dindo grade 2 or higher anastomotic leakage. Secondary outcomes included the duration from surgery to oral intake, hospital stay, and type and dose of analgesics used during hospitalization.
Results
Fifty-two and 54 patients were randomized to McKeown esophagectomy with non-placement and placement of a cervical drainage tube, respectively. There was no significant difference in anastomotic leakage rates between the drain placement. However, non-inferiority was not demonstrated (13/54 [24%]) and non-placement groups (12/52 [23%]; risk difference, -0.100 [-0.17, 0.15]; p = 0.0591). There were no significant differences in the secondary outcome measures.
Conclusion
Non-inferiority of nonplacement of a drainage tube around the cervical anastomosis after McKeown esophagectomy to placement of that was not demonstrated. Further large multicenter studies are needed.
Trial registration
: Japan Registry of Clinical Trials (identification number: jRCT1052180016).
Analysis of abrasive impact wear of a bimetal composite using a newly designed wear testing rig
Authors: Yuan Shengnan , Wu Hui , Xie Haibo , Jia Fanghui , Liang Xiaojun , Zhao Xing , Jiao Sihai , Jiang Zhengyi 
Published: May 2024

Abstract

In this study, the abrasive impact wear behaviour of a bimetal composite made of MMSs and LCSs (Mn8/SS400) were investigated by comparison with the existing wear resistant steels (benchmark steels) using a newly designed wear testing rig. The parameters including wear loss, wear rate, and hardness were evaluated. Scanning electron microscopy (SEM), X-ray diffractometer (XRD), and electron backscatter diffraction (EBSD) were used to analyse the wear mechanisms. The wear resistance of Mn8/SS400 bimetal composite is up to 2.8 times higher than that of benchmark steels due to better work hardening sensitivity of the bimetal composite. After 300 h abrasive impact wear, the highest microhardness of the subsurface layer for Mn8 reaches 601.31 HV, which is much greater than that of matrix (292.24 HV), showing a remarkable work hardening effect. The wear mechanism of Mn8/SS400 bimetal composite is ascribed to synergistic effect of grain refinement strengthening, dislocation strengthening, and twin strengthening. Prior to the 200-h abrasive impact wear test, the dominant wear mechanism in the Mn8/SS400 bimetal composite is primarily attributed to twin strengthening. However, following the 300-h impact wear test, the contribution to wear resistance becomes increasingly significant from all three strengthening mechanisms (dislocation, grain refinement, and twin strengthening).
Proteomic profiling identifies muscle-invasive bladder cancers with distinct biology and responses to platinum-based chemotherapy
Authors: Contreras-Sanz Alberto , Negri Gian Luca , Reike Moritz , Oo Htoo Zarni , Scurll Joshua , Miko Sandra Spencer , Nielsen Karina , Ikeda Kenichiro , Wang Gang , Jackson Chelsea , Gupta Shilpa , Roberts Morgan , Berman David , Seiler Roland , Morin Gregg , Black Peter 
Published: May 2024

Abstract

Platinum-based neoadjuvant chemotherapy (NAC) prior to radical cystectomy is the preferred treatment for muscle-invasive bladder cancer (MIBC) despite modest survival benefit and significant associated toxicities. Here, we profiled the global proteome of MIBC tumours pre- and post-NAC treatment using archival formalin-fixed paraffin-embedded tissue. We identified four pre-NAC proteomic clusters with distinct biology and response to therapy and integrated these with transcriptomic subtypes and immunohistochemistry. We observed proteomic plasticity post-NAC that was associated with increased extracellular matrix and reduced keratinization compared to pre-NAC. Post-NAC clusters appeared to be differentially enriched for druggable proteins. For example, MTOR and PARP were over-expressed at the protein level in tumours identified as neuronal-like. In addition, we determined that high intratumoural proteome heterogeneity in pre-NAC tissue was associated with worse prognosis. Our work highlights new aspects of MIBC tumour biology associated with clinical outcomes, and suggests new biomarkers and therapeutic targets based on proteomic clusters.
A retrospective cohort study of coagulation function in patients with liver cirrhosis receiving cefoperazone/sulbactam with and without vitamin K1 supplementation
Authors: Liu Jianmo , Xiao Jingyang , Wu Hongfei , Ye Jinhua , Li Yun , Zou Bin , Li Yixiu 
Published: May 2024

Abstract

Background Cefoperazone/sulbactam is commonly prescribed for the treatment of infected patients with cirrhosis.Aim To investigate the effect of cefoperazone/sulbactam on coagulation in cirrhotic patients and assess the efficacy of vitamin K1 supplementation in preventing cefoperazone/sulbactam-induced coagulation disorders.Method This retrospective cohort study compared coagulation function in 217 cirrhotic patients who received Cefoperazone/sulbactam with and without vitamin K1 supplementation (vitamin K1 group, n = 108; non-vitamin K1 group, n = 109).Results In the non-vitamin K1 group, the post-treatment prothrombin time (PT) was 16.5 ± 6.5s and the activated partial thromboplastin time (aPTT) was 34.8 ± 9.4s. These were significantly higher than pre-treatment values (PT: 14.6 ± 2.4s, p = 0.005; aPTT: 30.4 ± 5.9s, p < 0.001). In the vitamin K1 group, no differences were observed in PT, thrombin time, or platelet count, except for a slightly elevated post-treatment aPTT (37.0 ± 10.4s) compared to that of pre-treatment (34.4 ± 7.2s, p = 0.033). The vitamin K1 group exhibited a lower risk of PT prolongation (OR: 0.211, 95% CI: 0.047–0.678) and coagulation disorders (OR: 0.257, 95% CI: 0.126–0.499) compared to that of the non-vitamin K1 group. Propensity score matching analysis confirmed a reduced risk in the vitamin K1 group for prolonged PT (OR: 0.128, 95% CI: 0.007–0.754) and coagulation disorders (OR: 0.222, 95% CI: 0.076–0.575). Additionally, the vitamin K1 group exhibited lower incidences of PT prolongation, aPTT prolongation, bleeding, and coagulation dysfunction compared to the non-vitamin K1 group.Conclusion Cefoperazone/sulbactam use may be linked to a higher risk of PT prolongation and coagulation disorders in cirrhotic patients. Prophylactic use of vitamin K1 can effectively reduce the risk.