bluuebunny/crossref_metadata_2025_split huggingface dataset:
Modelling lake stage and water balance of Lake Tana, Ethiopia
Authors: Chebud Yirgalem A. , Melesse Assefa M. 
Published: October 2009

AbstractThe level of Lake Tana, Ethiopia, fluctuates annually and seasonally following the patterns of changes in precipitation. In this study, a mass balance approach is used to estimate the hydrological balance of the lake. Water influx from four major rivers, subsurface inflow from the floodplains, precipitation, outflow from the lake constituting river discharge and evapotranspiration from the lake are analysed on monthly and annual bases. Spatial interpolation of precipitation using rain gauge data was conducted using kriging. Outflow from the lake was identified as the evaporation from the lake's surface as well as discharge at the outlet where the Blue Nile commences. Groundwater inflow is estimated using MODular three‐dimensional finite‐difference ground‐water FLOW model software that showed an aligned flow pattern to the river channels. The groundwater outflow is considered negligible based on the secondary sources that confirmed the absence of lake water geochemical mixing outside of the basin. Evaporation is estimated using Penman's, Meyer's and Thornwaite's methods to compare the mass balance and energy balance approaches. Meteorological data, satellite images and temperature perturbation simulations from Global Historical Climate Network of National Oceanographic and Atmospheric Administration are employed for estimation of evaporation input parameters. The difference of the inflow and outflow was taken as storage in depth and compared with the measured water level fluctuations. The study has shown that the monthly and annually calculated lake level replicates the observed values with root mean square error value of 0·17 and 0·15 m, respectively. Copyright © 2009 John Wiley & Sons, Ltd.
Cumulus cell‐enclosed oocytes acquire a capacity to synthesize GSH by FSH stimulation during in vitro maturation in pigs
Authors: Ozawa Manabu , Nagai Takashi , Somfai Tamás , Nakai Michiko , Maedomari Naoki , Miyazaki Hitoshi , Kaneko Hiroyuki , Noguchi Junko , Kikuchi Kazuhiro 
Published: October 2009

AbstractWe investigated (i) follicle stimulating hormone (FSH)‐modulated changes in the expression of glutathione (GSH) and its rate‐limiting enzyme, glutamate cysteine ligase (GCL), in porcine oocytes and cumulus cells, and (ii) the contribution of gap‐junctional communications (GJCs) in cumulus‐oocyte complexes (COCs) to intraoocyte GSH accumulation. In experiment (i), COCs were cultured for 48 h with (+FSH group) or without FSH (−FSH group). The GSH content of oocytes increased with cultivation time in the +FSH group, but decreased in the −FSH group. The GSH content of cumulus cells at 48 h was also higher in the +FSH group than that in the −FSH group. Expression of GCL subunit mRNAs in oocytes and cumulus cells was increased by FSH stimulation until 12 h, and then fell to the baseline level. On the other hand, the amount of GCL subunit proteins in oocytes and cumulus cells increased gradually throughout the period of culture with FSH. In experiment (ii), blocking of GJCs in COCs during 0–24 h of culture led to a decrease in the GSH content of oocytes at 24 h of culture, whereas the GSH content at 48 h of culture did not differ even after blocking of the GJCs during 24–48 h of culture. These findings indicate that FSH initiates GSH synthesis in cumulus cells and oocytes by modulating the expression of GCL, and that porcine oocytes are able to synthesize GSH without GJC‐mediated support from cumulus cells, at least in the later half of maturation culture. J. Cell. Physiol. 222: 294–301, 2010. © 2009 Wiley‐Liss, Inc.
Comparative development of the crocodylian interclavicle and avian furcula, with comments on the homology of dermal elements in the pectoral apparatus
Authors: Vickaryous Matthew K. , Hall Brian K. 
Published: October 2009

AbstractThe pectoral apparatus (shoulder girdle plus sternum) of amniotes plesiomorphically includes an unpaired element of dermal origin. In crocodylians, lepidosaurs, and nontherian synapsids (monotremes and their ancestors) this element is identified as the interclavicle, in Testudines (turtles and tortoises) as the entoplastron, and in Aves as the furcula. We investigated embryonic development of the interclavicle in Alligator mississippiensis (American alligator) and of the furcula in Gallus gallus (domestic chicken). The interclavicle and furcula are among the first skeletal elements to ossify, beginning at Ferguson stage 19 (Alligator) and Hamburger and Hamilton stage 33 (Gallus). Both elements: occupy a similar mid‐ventral position within the pectoral apparatus; develop from paired (bilateral) cell condensations; never coexist at anytime during ontogeny or in the adult; and undergo intramembranous (i.e., direct) ossification. For both the interclavicle and the furcula, the initial onset of ossification is concomitant with mineralization of elements of the dermatocranium, and occurs in advance of mineralization of the replacement bones (e.g., scapula, metacoracoid) of the pectoral apparatus. Shortly after the initiation of ossification the paired condensations of both elements fuse. For each of Alligator and Gallus, only one pair of skeletogenic condensations is present during embryonic development. Based on these data and a review of the evolution and development of dermal elements in the pectoral apparatus, we conclude that the interclavicle is equally parsimonious as a homolog of the furcula. J. Exp. Zool. (Mol. Dev. Evol.) 314B:196–207, 2010. © 2009 Wiley‐Liss, Inc.
A further investigation on a MALDI‐based method for evaluation of markers of renal damage
Authors: Lapolla Annunziata , Molin Laura , Sechi Annalisa , Cosma Chiara , Ragazzi Eugenio , Seraglia Roberta , Traldi Pietro 
Published: October 2009

AbstractThe validity of the urinary protein profile to characterize the pathological states of diabetic, nephropathic and diabetic–nephropathic patients was considered on the basis of previously obtained results by MALDI/MS, showing a different abundance ratio of the collagen α1 and α5 chain precursor fragments at m/z 1219 and 2049 and of the uromodulin precursor fragment at m/z 1912 observed in healthy subjects and patients; a larger number of subjects was examined and the obtained results were statistically evaluated. The p values related to the observed differences indicate that they are statistically significant when comparing all patients versus healthy controls, diabetic with normo or microalbuminuria versus nephropathic with advanced renal disease patients and diabetic with normo or microalbuminuria versus diabetic with advanced nephropathy patients. The scatter plot matrix gives evidence of the strict inverse relationship between the abundances of ions at m/z 1912 and 1219, the correlation coefficient being particularly high (r = 0.921, p < 0.001). The relationship between the true positive rate (sensitivity) and false positive rate (1—specificity) for every possible cutoff value in abundance of the considered ionic species was investigated through the receiver‐operating characteristic (ROC) curve. The obtained data indicate that a good differentiation of nephropathic patients with advanced renal disease and diabetic patients with advanced nephropathy versus healthy subjects can be easily obtained by this approach. Copyright © 2009 John Wiley & Sons, Ltd.
Age, work experience, and the psychological contract
Authors: Ng Thomas W. H. , Feldman Daniel C. 
Published: October 2009

AbstractThe purpose of the current paper is to examine the ways in which age and work experience shape how individuals experience psychological contract breaches. We first introduce the concepts of contract malleability (the degree to which individuals can tolerate deviations from contract expectations) and contract replicability (the degree to which individuals believe that their psychological contracts can be replicated elsewhere). Next, we discuss the variety of reasons why contract malleability and replicability become greater with age and work experience and how contract malleability and replicability may temper negative reactions to psychological contract breaches. We also address the different ways contract malleability and replicability mediate the relationships between age and work experience, on one hand, and exit, voice, loyalty, and neglect behaviors on the other. We consider the moderating effects of age similarity and dissimilarity here as well. The paper concludes with a discussion of the implications for future research designs and for managing older and more experienced workers. Copyright © 2009 John Wiley & Sons, Ltd.
A typology of solo independent women travellers
Authors: McNamara Karen Elizabeth , Prideaux Bruce 
Published: October 2009

AbstractThis paper aims to profile solo independent women travellers in Tropical North Queensland, describe their key motivations for travel and behaviours, and locate this group on a typology of solo independent travellers in Australia. Previous research has painted solo independent women at one end of a travel spectrum as fearful and risk‐adverse and at another end, as risk‐takers who have few concerns about safety within the destination. This analysis is based on visitor surveys completed over 21 months at Cairns Airport (n = 2,618). The results indicated that solo independent women travellers (n = 228) felt safe in the destination and participated in a wide variety of activities including those with some degree of risk. Copyright © 2009 John Wiley & Sons, Ltd.
Sporadic late onset nemaline myopathy responsive to IVIg and immunotherapy
Authors: Milone Margherita , Katz Amiram , Amato Anthony A. , Soderland Carl A. , Segarceanu Miruna , Young Nathan P. , Jones H. Royden 
Published: October 2009

AbstractSporadic late onset nemaline myopathy (SLONM) is a progressive myopathy of indeterminate etiology and poor outcome. If associated with a monoclonal gammopathy, SLONM carries a more unfavorable prognosis. Immunotherapy was unsuccessful. We report two HIV‐negative SLONM/monoclonal gammopathy patients who improved following intravenous immunoglobulin (IVIg) treatment alone or in combination with immunosuppressant agents. This favorable response to treatment suggests that a dysimmune mechanism is operative in some SLONM individuals. We suggest that IVIg deserves initial consideration for SLONM therapy. Muscle Nerve, 2010
Rituximab in the management of refractory myasthenia gravis
Authors: Zebardast Nazlee , Patwa Huned S. , Novella Steven P. , Goldstein Jonathan M. 
Published: October 2009

AbstractMyasthenia gravis (MG) is an immune‐mediated disorder with a variable response to treatment. In this study, patients with refractory MG who were treated with rituximab were identified. A review of patients referred to the Yale Neuromuscular Clinic was performed. Patients with refractory MG who were treated with rituximab were reviewed for response to treatment. Patients who had muscle‐specific kinase (MuSK+) or acetylcholine receptor (AChR+) antibodies were included. Six patients were identified who met the criteria described. All patients tolerated rituximab without side effects and had a reduced need for immunosuppressants and/or improvement in clinical function. Patients with refractory MG appeared to respond to rituximab in this small, retrospective study. This result suggests that a larger, prospective trial is indicated. Muscle Nerve, 2009
The effect of particle shape and grain‐scale properties of shale: A micromechanics approach
Authors: Ortega J. A. , Ulm F.‐J. , Abousleiman Y. 
Published: October 2009

AbstractTraditional approaches for modeling the anisotropic elasticity response of the highly heterogeneous clay fabric in shale have mainly resorted to geometric factors such as definitions of particles shapes and orientations. However, predictive models based on these approaches have been mostly validated using macroscopic elasticity data. The recent implementation of instrumented indentation aimed at probing nano‐scale mechanical behaviors has provided a new context for characterizing and modeling the anisotropy of the porous clay in shale. Nanoindentation experimental data revealed the significant contribution of the intrinsic anisotropy of the solid clay to the measured elastic response. In this investigation, we evaluate both the effects of geometric factors and of the intrinsic anisotropic elasticity of the solid clay phase on the observed anisotropy of shale at multiple length scales through the development of a comprehensive theoretical micromechanics approach. It was found that among various combinations of these sources of anisotropy, the elastic response of the clay fabric represented as a granular ensemble of aligned effective clay particles with spherical morphology and anisotropic elasticity compares satisfactorily to nanoindentation and ultrasonic pulse velocity measurements at nano‐ and macroscopic length scales, respectively. Other combinations of sources of anisotropy could yield comparable predictions, particularly at macroscopic scales, at the expense of requiring additional experimental data to characterize the morphology and orientations of particles. Copyright © 2009 John Wiley & Sons, Ltd.
Axisymmetric interaction of a rigid disc with a transversely isotropic half‐space
Authors: Katebi Amir Aabbas , Khojasteh Ali , Rahimian Mohammad , Pak Ronald Y. S. 
Published: October 2009

AbstractA theoretical formulation is presented for the determination of the interaction of a vertically loaded disc embedded in a transversely isotropic half‐space. By means of a complete representation using a displacement potential, it is shown that the governing equations of motion for this class of problems can be uncoupled into a fourth‐order partial differential equation. With the aid of Hankel transforms, a relaxed treatment of the mixed‐boundary value problem is formulated as dual integral equations, which, in turn, are reduced to a Fredholm equation of the second kind. In addition to furnishing a unified view of existing solutions for zero and infinite embedments, the present treatment reveals a severe boundary‐layer phenomenon, which is apt to be of interest to this class of problems in general. The present solutions are analytically in exact agreement with the existing solutions for a half‐space with isotropic material properties. To confirm the accuracy of the numerical evaluation of the integrals involved, numerical results are included for cases of different degrees of the material anisotropy and compared with existing solutions. Further numerical examples are also presented to elucidate the influence of the degree of the material anisotropy on the response. Copyright © 2009 John Wiley & Sons, Ltd.
Hyaluronic acid ameliorates bladder hyperactivity via the inhibition of H2O2‐enhanced purinergic and muscarinic signaling in the rat
Authors: Yeh Chung‐Hsin , Chiang Han‐Sun , Chien Chiang‐Ting 
Published: October 2009

AbstractAimsWe hypothesize that increased H2O2 in the urinary bladder may affect ATP and acetylcholine release and activate urothelial purinergic and muscarinic signaling consequently leading to hyperactive bladder.Materials and MethodsWe infused 0.3% and 1.5% H2O2 to the urinary bladder to evaluate the voiding function and frequency, pelvic afferent (PANA) and pelvic efferent nerve activity (PENA) simultaneously in the urethane anesthetized rats. We measured ATP and acetylcholine content in the rat urinary bladder under saline or H2O2 stimulation. Hyaluronic acid, muscarinic, and purinergic receptor antagonists were used to evaluate their effects and mechanisms on H2O2‐induced hyperactive bladder.ResultsIntravesical H2O2 administration increased the frequency of voiding and the maximal amplitude of intravesical pressure (IVP) in the urethane anesthetized rats. Intravesical H2O2 decreased the threshold level of PANA and PENA for triggering micturition and increased ATP and acetylcholine contents in the H2O2‐treated bladder in the rat. Hyaluronic acid in vitro directly scavenged H2O2 in a dose‐dependent manner. Intravesical hyaluronic acid for 30 min attenuated H2O2‐elicited excitatory effects on the frequency of voiding, amplitude of IVP and the sensitization of PANA and PENA in the rats. Hyaluronic acid treatment reduced H2O2‐induced ATP and acetylcholine release in the urinary bladder. Intravesical administration of muscarinic receptor antagonist atropine methyl nitrate (50 µM) or purinergic receptor antagonist PPADS (1 mM) ameliorated H2O2‐induced hyperactive bladder.ConclusionsThese results indicate that hyaluronic acid treatment can ameliorate H2O2‐induced bladder hyperactivity possibly via the antioxidant activity and the inhibition of activating purinergic and muscarinic signaling pathway. Neurourol. Urodynam. 29:765–770, 2010. © 2010 Wiley‐Liss, Inc.
The Journal of Pathology 2008 Jeremy Jass Prize for Research Excellence in Pathology
Authors: Hall Peter A , Poulsom Richard , Coates Philip J , Du Ming‐Qing , Hogendoorn Pancras CW , Jones Louise J , Ladanyi Marc , Murray Graeme I , Niedobitek Gerald 
Published: October 2009

AbstractThe first Jass Prize for Research Excellence has been awarded to a group from Hannover in Germany. These authors discovered the epigenetic inactivation of microRNA gene hsa‐mir‐9‐1 in human breast cancer and characterized its biological and clinical relevance. This frequent epigenetic silencing was found to occur early in the development of breast cancer, and illustrates another mechanism by which tumour development is influenced by genes that operate without expression as proteins. Copyright © 2009 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
Adjuvant dendritic cell‐based tumour vaccination for children with malignant brain tumours
Authors: Ardon Hilko , De Vleeschouwer Steven , Van Calenbergh Frank , Claes Laurence , Kramm Christof M. , Rutkowski Stefan , Wolff Johannes E.A. , Van Gool Stefaan W. 
Published: October 2009

AbstractBackgroundA large experience with dendritic cell (DC)‐based vaccination for malignant brain tumours has been gained in adults. Here we focus on the results obtained in children with relapsed malignant brain tumours.ProcedureIn total 45 children were vaccinated: 33 high grade glioma (HGG), 5 medulloblastoma (MB)/primitive neuro‐ectodermal tumour (PNET), 4 ependymoma and 3 atypical teratoid‐rhabdoid tumour (ATRT). Autologous, monocyte‐derived DC were generated and loaded with tumour lysate, which was used as source of tumour‐associated antigens.ResultsIn 38 patients peripheral blood mononuclear cells (PBMC) were obtained from leukapheresis and in 7 patients from fresh blood samples. 7 HGG patients are still alive with median follow‐up (FU) of 35.7 months (range: 12.1–85.6). Median overall survival (OS) was 13.5 months (range: 1.4–85.6). All patients with MB/PNET died (median OS 5.7 months; range 4.3–51.2). One patient with ependymoma is still alive at 22.3 months FU. The other three patients died at, respectively, 7.7, 30.1 and 31.5 months. Two patients with ATRT are still alive at, respectively, 34.1 and 52.6 months FU. The third patient died at 50.5 months. No severe adverse events were noticed.ConclusionsIn this exploratory study, HGG and ATRT seem to respond more favourably to vaccination than MB/PNET and ependymoma. Although preliminary, our results are promising and support further testing of DC‐based immunotherapy in new treatment protocols for HGG and ATRT. Pediatr Blood Cancer 2010;54:519–525. © 2009 Wiley‐Liss, Inc.
Barrier properties of organic–inorganic hybrid coatings based on polyvinyl alcohol with improved water resistance
Authors: Minelli Matteo , De Angelis Maria Grazia , Doghieri Ferruccio , Rocchetti Marco , Montenero Angelo 
Published: October 2009

AbstractA comprehensive study of the gas barrier properties of hybrid organic–inorganic coatings formed by polyvinyl alcohol (PVOH) and Si‐SiO2, obtained via sol–gel technique, was carried out. It has been shown that the oxygen, nitrogen and carbon dioxide transfer rates of barrier polymers such as poly(ethylene terephthalate) and oriented polypropylene can be further reduced, by up to two orders of magnitude, with a thin coating (1–2 μm) of PVOH/Si‐SiO2. More notably, it has been observed that the material maintains this feature even after a prolonged contact with water, which is a strong solvent for PVOH. Direct moisture sorption measurements show that silica lowers the water uptake of PVOH and inhibits sorption‐induced swelling and plasticization of the polymer. Correlations between the gas transport properties of the hybrid coatings and factors such as the silica content, the type of polymeric substrate, the nature of penetrant and the temperature have been found, providing guidelines for the selection and design of multilayer materials for packaging applications. POLYM. ENG. SCI., 2010. © 2009 Society of Plastics Engineers
Preparation and evaluation of epoxy methacrylate UV‐curable coatings containing phthalazinone
Authors: Kou Yan , Wang Jinyan , Lv Mingxia , Jian Xigao 
Published: October 2009

AbstractEpoxy methacrylate resin (EMA) UV‐curable coatings exhibit high reactivity, low viscosity and excellent chemical resistance in environmentally friendly coatings. A novel EMA containing phthalazinone moieties for high temperature resistant UV‐curable coatings was synthesized. The formulations were cured with hexanediol diacrylate (HDDA) and trimethylol propane triacrylate (TMPTA) as reactive diluents promoted by a photoinitiator, and then interpenetrating polymer networks were generated. The mechanical, chemical and thermal properties of the clear coatings were characterized using Chinese National Standard methods (GB). EMA was used with UV radiation curing in combination with 6.7 wt% of HDDA and 13.4 wt% of TMPTA, and the properties of the cured films were as follows: pencil hardness of 5 H, 30% NaOH resistance for 30 days, 15% HCl resistance for 10 days, 3% NaCl resistance for 30 days and 5% weight loss temperature of 300.5 °C. EMA UV‐curable coatings containing phthalazinone exhibit excellent chemical and thermal stability, and could be potential candidates for UV‐curable zero volatile organic compound coatings applied in the fields of salt spray corrosion, strong radiation and high‐temperature resistance. Copyright © 2009 Society of Chemical Industry
Rejection sensitivity and negative self‐beliefs as mediators of associations between the number of borderline personality disorder features and self‐reported adult attachment
Authors: Boldero Jennifer M. , Hulbert Carol A. , Bloom Lisa , Cooper Jae , Gilbert Flora , Mooney Jessica L. , Salinger Jodi 
Published: October 2009

AbstractThe present two studies examine associations between self‐reported adult anxious and avoidant attachment and the number of borderline personality disorder (BPD) features reported by student samples. In addition, they examine the mediating roles of rejection sensitivity (RS) (Studies 1 and 2) and negative self‐beliefs (Study 2) on associations, independent of neuroticism. In both studies, higher anxious and avoidant attachment were associated with reporting more features, and RS partially mediated these associations. In Study 2, the self‐belief negativity was an additional mediator. These factors partially mediated the impact of anxious attachment and fully mediated that of avoidant attachment. The results are consistent with an attachment‐based model of BPD that highlights the role of internal working models of self and others as antecedents of the sensitivity to rejection seen in many with BPD. Copyright © 2009 John Wiley & Sons, Ltd.