bluuebunny/crossref_metadata_2025_split huggingface dataset:
Longitudinal follow‐up and prognostic factors in nitrous oxide‐induced neuropathy
Authors: Fortanier Etienne , Delmont Emilien , Corazza Giovanni , Kouton Ludivine , Micallef Joelle , Attarian Shahram 
Published: May 2024

AbstractBackground and AimRecreational use of nitrous oxide (N2O) has been associated with the development of severe nitrous oxide‐induced neuropathy (N2On). Follow‐up of these patients poses challenges, and their clinical progression remains largely unknown. The identification of prognostic factors is made difficult by the lack of standardized longitudinal assessments in most studies. The objective was to document the course of neuropathy through systematic follow‐up assessments in N2On patients to identify prognostic factors for persistent disability after 6 months.MethodsWe gathered demographic, clinical, biological, and electrophysiological data from N2On patients hospitalized in the Referral center in Marseille, both at baseline and during a standardized follow‐up assessment at 6 months.ResultsWe retrospectively included 26 N2On patients (mean age 22.6 ± 4.4). Significant improvements were observed in all main clinical scores including Rankin, ONLS, and MRC testing (p < .01). Electrophysiological studies (EDX) revealed a predominantly motor neuropathy with marked reduction in CMAP in the lower limbs at baseline, and no significant improvement in motor parameters (p = .543). Rankin score at 6 months correlated with the initial weekly N2O consumption (r = .43, p = .03) and the CMAP sum score in the lower limbs at the first EDX (r = −.47, p = .02). Patients with and without myelitis showed similar Rankin and ONLS score after 6 months.InterpretationThe clinical course generally improved favorably at 6 months with notable amelioration in the primary disability scores, sensory deficits, and ataxia. However, distal motor impairment associated with peripheral neuropathy persisted, with distal axonal loss emerging as the main prognostic factor for long‐term disability in these young patients.
Machine learning evaluation of inequities and disparities associated with nurse sensitive indicator safety events
Authors: Georgantes Erika R. , Gunturkun Fatma , McGreevy T. J. , Lough Mary E. 
Published: May 2024

AbstractPurposeTo use machine learning to examine health equity and clinical outcomes in patients who experienced a nurse sensitive indicator (NSI) event, defined as a fall, a hospital‐acquired pressure injury (HAPI) or a hospital‐acquired infection (HAI).DesignThis was a retrospective observational study from a single academic hospital over six calendar years (2016–2021). Machine learning was used to examine patients with an NSI compared to those without.MethodsInclusion criteria: all adult inpatient admissions (2016–2021). Three approaches were used to analyze the NSI group compared to the No‐NSI group. In the univariate analysis, descriptive statistics, and absolute standardized differences (ASDs) were employed to compare the demographics and clinical variables of patients who experienced a NSI and those who did not experience any NSIs. For the multivariate analysis, a light grading boosting machine (LightGBM) model was utilized to comprehensively examine the relationships associated with the development of an NSI. Lastly, a simulation study was conducted to quantify the strength of associations obtained from the machine learning model.ResultsFrom 163,507 admissions, 4643 (2.8%) were associated with at least one NSI. The mean, standard deviation (SD) age was 59.5 (18.2) years, males comprised 82,397 (50.4%). Non‐Hispanic White 84,760 (51.8%), non‐Hispanic Black 8703 (5.3%), non‐Hispanic Asian 23,368 (14.3%), non‐Hispanic Other 14,284 (8.7%), and Hispanic 30,271 (18.5%). Race and ethnicity alone were not associated with occurrence of an NSI. The NSI group had a statistically significant longer length of stay (LOS), longer intensive care unit (ICU) LOS, and was more likely to have an emergency admission compared to the group without an NSI. The simulation study results demonstrated that likelihood of NSI was higher in patients admitted under the major diagnostic categories (MDC) associated with circulatory, digestive, kidney/urinary tract, nervous, and infectious and parasitic disease diagnoses.ConclusionIn this study, race/ethnicity was not associated with the risk of an NSI event. The risk of an NSI event was associated with emergency admission, longer LOS, longer ICU‐LOS and certain MDCs (circulatory, digestive, kidney/urinary, nervous, infectious, and parasitic diagnoses).Clinical RelevanceMachine learning methodologies provide a new mechanism to investigate NSI events through the lens of health equity/disparity. Understanding which patients are at higher risk for adverse outcomes can help hospitals improve nursing care and prevent NSI injury and harm.
Neonatal head circumference to maternal mid‐transverse pelvic distance ratio as a key anatomical predictor for dystocia: Retrospective case–control study
Authors: Baek Min Jung , Na Eun Duc , Lee Hanna , Park So Hyeon , Kim Seoyeon , Kim Taeho , Jung Sang Hee , Jang Ji Hyon 
Published: May 2024

AbstractObjectiveThis study aimed to examine maternal and neonatal factors in cesarean deliveries due to dystocia, including cephalopelvic disproportion, latent‐phase prolongation, and fetal malposition or malpresentation. Additionally, we sought to compare the differences between the dystocia subgroups.Method and MaterialsThis retrospective case–control study included women who delivered between January 2010 and June 2021 after 37 weeks of pregnancy and underwent abdominal‐pelvic CT scans within 5 years before and after delivery. Neonatal factors were extracted from medical charts immediately after delivery.ResultsAmong the 292 women studied, those with cesarean deliveries for dystocia were older (mean ± SD, 34.2 ± 4.27 vs. 32.2 ± 3.8, p‐value = 0.002), had higher pre‐pregnancy BMI (22.7 ± 3.67 vs. 21.4 ± 3.48, p‐value = 0.012) and term‐BMI (27.4 ± 3.72 vs. 25.9 ± 3.66, p‐value = 0.010), shorter interspinous distance (ISD, the distance between ischial spine) (10.8 ± 0.76 vs. 11.2 ± 0.85 cm, p‐value = 0.003), and longer head circumference (HC) (35 ± 1.47 vs. 34.4 ± 1.36 cm, p‐value = 0.003) compared to those who had vaginal deliveries. Univariate logistic regression for dystocia revealed associations between HC/maternal height and HC/ISD ratios (OR, 2.02 [95% confidence interval, CI, 1.4 ~ 2.92], 12.13 [3.2 ~ 46.04], respectively). Multivariate logistic analysis indicated that maternal age, ISD, and HC were significant factors for dystocia (OR, 1.11 [95% CI, 1.01 ~ 1.21], 0.49 [0.26 ~ 0.91], 1.53 [1.07 ~ 2.19], respectively). The subgroup with latent‐phase prolongation exhibited the lowest birthweight/term‐BMI ratio (124 ± 18.8 vs. 113 ± 10.3 vs. 134 ± 19.1, p‐value = 0.013).ConclusionThe HC/ISD ratio emerged as a crucial predictor of dystocia, suggesting that reducing term‐BMI could potentially mitigate latent‐phase prolongation. Further research assessing the maternal mid‐pelvis during pregnancy and labor is warranted, along with efforts to reduce BMI during pregnancy.
Towards a decolonial developmental science: Adolescent development in the Majority World taking center stage
Authors: Abubakar Amina , Brandelli Costa Angelo , Cui Lixian , Koller Silvia H. , Nwafor Chidozie Edwin , Raval Vaishali V. 
Published: May 2024

AbstractWhile aspiring to be a diverse and global science, developmental science continues to be dominated by EuroAmerican epistemologies, researchers, and communities in its published scholarship. Adolescents in communities across Africa, Asia, the Middle East, and Latin America comprise 85% of the world's adolescent population, and yet their experiences and perspectives are marginalized in our science. Adolescents in the Majority World live in highly diverse social, cultural, political, economic, educational and healthcare contexts that contribute to their development, and we have much to learn from their experiences. This article situates the marginalization of the global majority within coloniality embedded in developmental science. The article describes the impetus for this special issue Towards a decolonial developmental science and the process of putting it together, along with providing an overview of the 18 articles in this collection that push us towards decoloniality. The special issue serves as a call to transform developmental science to be decolonial by empowering adolescent development in Majority World communities to take center stage. Adolescent development research from Majority World communities has the potential to challenge the knowledge base generated from Minority World samples, contributing to a science that is comprehensive, inclusive, and can inform prevention and intervention efforts to support the well‐being of adolescents globally.
Evaluation of antagonistic activity of DAPG‐producing fluorescent pseudomonads from rhizospheres of Solanaceous crops for biocontrol of bacterial wilt
Authors: Suansia Anjali , Senapati Akshaya Kumar , Samantaray Deviprasad , Mohanty Mahendra Kumar 
Published: May 2024

AbstractPseudomonads produce a wide array of antimicrobial compounds including 2,4‐diacetylphloroglucinol (DAPG), which possess a broad‐spectrum antagonistic effect against phytopathogens. Rhizospheric soil samples were collected from the Solanaceous crops for isolation of fluorescent pseudomonads (FPs). Out of the 32 fluorescent bacterial isolates, 21 showed antagonistic activity against Ralstonia solanacearum (NAIMCC‐B‐01630) with the highest zone of inhibition at 38.33 mm. Among them, 11 bacterial isolates depicted the production of DAPG in Kings' B medium. DAPG production was detected by TLC and quantified through HPLC analysis. Moreover, the bacterial isolate OD13 exhibited higher DAPG production. Further, the presence of the DAPG‐encoding phlD gene within the size of 629 bp and 725 bp was also validated through amplification. These bacterial isolates belonged to the genera Pseudomonas as confirmed by morpho‐physiological characterization using the VITEK 2 system. The higher DAPG‐producing bacterial isolate was identified as Pseudomonas aeruginosa by polyphasic approach with GenBank accession number OQ781265. Thus, the DAPG‐producing rhizospheric Pseudomonas strains can be used as biocontrol agents for bacterial wilt. However, field study is highly essential before its successful application.
Shifting the perspective on labor exploitation: Non‐commercial organizations' contribution toward supply chain governance
Authors: Shirgholami Zahra , Cole Rosanna , Aitken James 
Published: May 2024

AbstractLabor exploitation persists within global supply chains regardless of governmental legislation, private governance mechanisms, and increasing consumer demands. Notably, non‐commercial organizations have been lauded as potential facilitators of improvements in labor standards through their capability to influence supply chain actors. Through an analysis of 45 semi‐structured interviews across three cases, this research provides rich evidence of non‐commercial organizations' contribution to governance linked to the persistence of labor exploitation. The findings reveal that the constraining factors of change capabilities of non‐commercial organizations are (1) recognition of their limitations to enact improvements when their organizations are positioned in a heterogeneous supply chain context, (2) lack of a level playing field that provides a fair competitive environment to improve labor standards, and (3) labor deregulation. Similarly, the complex situation faced by non‐commercial organizations created dilemmas that hindered progress in addressing labor exploitation. Governance inertia is an overarching issue that circumscribes the ambitions of non‐commercial organizations to enhance labor standards. This research emphasizes the issues and challenges that constrain these uniquely placed organizations in facilitating positive change in global apparel supply chains.
Treatment outcomes of digital nasoalveolar moulding in infants with cleft lip and palate: A systematic review with meta‐analysis
Authors: Chaudhari Prabhat Kumar , Rajasekaran Abirami , Haldar Partha , Zere Edlira , Dhingra Kunaal , Manas Raj Kumar , Yang Xianrui 
Published: May 2024

AbstractThe aim of this systematic review was to compare the treatment outcomes of digital nasoalveolar moulding (dNAM) technique with conventional nasoalveolar moulding (cNAM) or non‐presurgical intervention protocol in infants with unilateral (UCLP) or bilateral (BCLP) cleft lip and palate. A bibliometric search by MEDLINE (via Ovid), Embase, Cochrane Library, grey literature and manual method was conducted without language restriction until November 2023. Literature screening and data extraction were undertaken in Covidence. The risk of bias was evaluated using the Newcastle‐Ottawa Scale and RoB‐2. Pooled effect sizes were determined through random‐effects statistical model using R‐Software, and the certainty of evidence was assessed using the GRADE approach. Among 775 retrieved articles, nine studies were included for qualitative synthesis (6‐UCLP, 3‐BCLP), with only three eligible UCLP studies for meta‐analysis. In the UCLP group, very low certainty of evidence indicated no difference in alveolar cleft width (SMD, 0.13 mm; 95% CI, −0.31 to 0.57; I2, 0%), soft tissue (lip) cleft gap, nasal width, nasal height, and columellar deviation angle changes between dNAM and cNAM. In the BCLP group, qualitative synthesis suggested similar changes in alveolar, lip, and nasal dimensions with dNAM and cNAM. In both cleft groups (UCLP, BCLP), reduced alveolar cleft width was observed in the dNAM group compared to the non‐presurgical intervention protocol, along with fewer clinical visits and reduced chairside time for dNAM compared to cNAM. It can be concluded that the treatment outcomes with dNAM were comparable to cNAM in reducing malformation severity and were advantageous in terms of chairside time and clinical visit frequency. However, the overall quality of evidence is very low and standardization is needed for the virtual workflow regarding the alveolar movements and growth factor algorithms. Registration: PROSPERO‐database (CRD42020186452).
Childhood atopic disorders in relation to placental changes—A systematic review and meta‐analysis
Authors: Bakoyan Zaki , Cao Yang , Hansson Stefan R. , Karlsson Johanna Patriksson , Lodefalk Maria 
Published: May 2024

AbstractFetal programming may arise from prenatal exposure and increase the risk of diseases later in life, potentially mediated by the placenta. The objective of this systematic review was to summarize and critically evaluate publications describing associations between human placental changes and risk of atopic disorders during childhood. The review adhered to the Preferred Reporting Items for Systematic Reviews and Meta‐analysis guidelines. The inclusion criteria were original research articles or case reports written in English describing a human placental change in relation to disease occurring in offspring during childhood. The MEDLINE and EMBASE databases were searched for eligible studies. Risk of bias (RoB) was assessed using the ROBINS‐I tool. The results were pooled both in a narrative way and by a meta‐analysis. Nineteen studies were included (n = 12,997 participants). All studies had an overall serious RoB, and publication bias could not be completely ruled out. However, five studies showed that histological chorioamnionitis in preterm‐born children was associated with asthma‐related problems (pooled odds ratio = 3.25 (95% confidence interval = 2.22–4.75)). In term‐born children, a large placenta (≥750 g) increased the risk of being prescribed anti‐asthma medications during the first year of life. Placental histone acetylation, DNA methylation, and gene expression differences were found to be associated with different atopic disorders in term‐born children. There is some evidence supporting the idea that the placenta can mediate an increased risk of atopic disorders in children. However, further studies are needed to validate the findings, properly control for confounders, and examine potential mechanisms.
Septic arthritis of the cervical facet joint: Clinical report and review of the literature
Authors: Quoilin Melanie , Vu Peter D. , Bansal Vishal , Chen Jason W. 
Published: May 2024

AbstractBackgroundFacet joint septic arthritis (FJSA) is an uncommon cause of neck pain, most frequently occurring in the lumbosacral spine. Cervical facet joint septic arthritis is particularly rare. Symptoms typically include spinal or paraspinal pain and tenderness, with severe infections potentially causing neurological impairments. This condition can progress to discitis and osteomyelitis. High clinical suspicion is required for accurate diagnosis and timely treatment.ObjectiveTo present the first known case of cervical spine FJSA caused by Moraxella species and provide an updated narrative review of cervical spine FJSA.MethodsA case study of a 66‐year‐old male with cervical spine FJSA caused by Moraxella osloensis is detailed. Additionally, a librarian‐assisted literature search was conducted on MEDLINE Pubmed, filtering for adult human trials and including various study types, resulting in the inclusion of 9 relevant manuscripts.ResultsThe patient’s symptoms included neck, right upper thoracic, and periscapular pain, with episodes of numbness and tingling. MRI revealed septic arthritis at the C7‐T1 facet joint and associated osteomyelitis. Cultures identified Moraxella osloensis as the causative agent. The patient was successfully treated with antibiotics and experienced significant symptom improvement. Literature review highlights that Staphylococcus aureus is the most common causative agent of cervical FJSA, with diagnosis typically involving MRI and culture tests. Treatment generally includes long‐term antibiotics, with some cases requiring surgical intervention.ConclusionsThis report underscores the need for high clinical suspicion in diagnosing FJSA and highlights the importance of early intervention. It documents the first known case of cervical spine FJSA caused by Moraxella osloensis, contributing valuable information to the limited literature on this rare condition.
Severe congenital ichthyosiform dermatosis in CHIME syndrome successfully treated with ixekizumab
Authors: Flowers Lauren E. , Dyer Jonathan A. , Eisenstein Kimberly A. 
Published: May 2024

AbstractColoboma, congenital heart disease, ichthyosiform dermatosis, intellectual disability, conductive hearing loss, and epilepsy (CHIME) syndrome is a rare autosomal recessive neuroectodermal disorder caused by PIGL gene mutations. There is emerging literature to support the use of interleukin‐17 (IL‐17) antagonists in the treatment of certain ichthyosiform dermatoses. Here, we report a case of severe ichthyosiform dermatosis in a child with CHIME syndrome who was recalcitrant to multiple topical medications and dupilumab. This is the first reported case of successful treatment of congenital ichthyosiform dermatosis in a CHIME syndrome patient with ixekizumab, an IL‐17A antagonist.
The burden of treatment of propranolol for infantile hemangiomas: A mixed methods study
Authors: O'Connor Cathal , Murphy Michelle 
Published: May 2024

AbstractThe burden of treatment (BOT) related to propranolol treatment for infantile hemangiomas (IH) has never previously been explored. A modified validated questionnaire, the Treatment Burden Questionnaire, and one‐on‐one semi‐structured interviews were used to assess the BOT for propranolol for IH. Out of 80 caregivers, the overall burden score was very low at 1.2 out of 10; thematic analysis of interviews grouped themes into administration, monitoring, financial, and associated anomalies. The BOT of propranolol for IH is very low but could be reduced further by offering age‐based risk stratification related to feeding frequency and risk of hypoglycemia, pragmatic advice around timing of doses before sleep, and reducing frequency of vital sign monitoring.
Coinfection of cotton plants with cotton leafroll dwarf virus‐atypical and a novel cotton begomovirus
Authors: Delfosse Veronica C. , Debat Humberto , Zavallo Diego , Alvarez Liliana , Gomez‐Talquenca Sebastien , Bonacic Kresic Ivan , Asurmendi Sebastián , Distéfano Ana J. 
Published: May 2024

AbstractCotton is a commercial crop of global importance whose versatile fibre is widely used in the textile industry. Cotton is vulnerable to infectious pathogens, including viruses, that are a major threat to cotton production. Cotton blue disease is caused by cotton leafroll dwarf virus (CLRDV), a polerovirus transmitted by aphids. This virus is controlled by sowing cotton varieties resistant to CLRDV, although, in recent years an atypical variant (CLRDV‐at), that breaks the resistance, has been identified. An outbreak of a disease occurred in cotton fields of the province of Chaco, in the north‐west of Argentina, in the 2014–2015 growing season. NuOpal cotton plants (a variety resistant to CLRDV and susceptible to CLRDV‐at) showed mosaic symptoms and had virus‐transmitting insect vectors, such as aphids and whiteflies (Bemisia tabaci). The symptoms were common for virus infections but different from those caused by CLRDV or CLRDV‐at. According to a reverse transcription‐PCR analysis with polerovirus primers and sequencing, the plants contained CLRDV‐at. To identify the complete virome of these plants, we performed a massive RNA‐based deep sequencing assay using Illumina technology. As a result, a new begomovirus that infects cotton in Argentina was identified. Structural and functional annotation indicated that its sequences corresponded to complete DNA components A and B of a novel New World bipartite begomovirus. Genetic distance and evolutionary analyses support that the detected sequences correspond to a new virus, which we propose to name cotton mosaic virus (CoMV). In addition, we report the first begomovirus and polerovirus coinfection in cotton.
Molecular characterization of Secreted in Xylem 1 (Six1) gene of Fusarium oxysporum causing wilt of potato (Solanum tuberosum)
Authors: Ghosal Debraj , Datta Bejoysekhar 
Published: May 2024

AbstractDeciphering effector genes of plant‐pathogenic fungi is key to understanding their role in pathogenicity because acquisition of such genes through horizontal transfer may result in emergence of new pathogenic races. A full‐length (837 bp) Six1 gene has been cloned and sequenced from the genome of Fusarium oxysporum FPo isolated from roots of wilted potatoes in West Bengal, India. The isolate was identified based on conidial morphology and sequencing of the 28S rDNA and elongation factor 1α gene. Koch's postulates established that the isolate could incite wilting in potato plants. The Six Gene Expression 1 gene (Sge1) was amplified from the isolate and compared with that of other wilt‐causing F. oxysporum isolates. The Six1 gene had no intron and it encoded 278 amino acids, with a calculated molecular weight of 30.6 kDa, estimated isoelectric point 5.66 and theoretical extinction coefficient of 57,410 M−1 cm−1. Multiple sequence alignment of SIX1 amino acid sequences showed that the length of SIX1 varied among F. oxysporum formae speciales and different isolates of the same forma specialis. The predicted secondary structure of FPoSIX1 contained four α‐helices and 14 β‐sheets. Its predicted tertiary structure showed 92% query coverage and 67.37% identity with the template of the SIX1 protein of F. oxysporum f. sp. lycopersici PDB code: 7t69. The QMEAN score of this model was −2.53 and the model was validated using the Ramachandran Phi/Psi plot. Structure analysis of the effector protein will be helpful to identify its specific function and recognition by the host resistance protein.