bluuebunny/crossref_metadata_2025_split huggingface dataset:
Lumbosacral transitional vertebrae in children and adolescents (literature review, illustrated with clinical observations)
Authors: Skryabin E. G. , Krivtsov A. Yu. , Kicherova O. A. , Klokov I. N. , Zotov P. B. , Akselrov M. A. 
Published: April 2024

Introduction An analysis of the medical literature devoted to various aspects of transitional lumbosacral vertebrae shows that there are very few publications covering the course of this disease in the pediatric and adolescent population.Aim To study the issues of epidemiology, diagnosis, treatment and prevention of transitional lumbosacral vertebrae in paediatric and adolescent patients based on the analysis of current medical literature and illustrate the material with our own clinical observations.Material and methods To analyze the literature on the topic, 75 papers published between 1984 and 2023 were selected. Among them, there were 7 (9.3 %) domestic literary sources, 68 (90.7 %) were foreign. In the process of searching for scientific articles, the resources of the electronic databases of current medical information PubMed and CyberLeninka were used.Results and discussion The incidence of transitional vertebrae in children and adolescents is 16.8 % of clinical observations, as reported. In the structure of the transitional vertebrae in children, type II of the disease predominates according to the classification Castellvi et al (1984), 43.2 % of cases. The main clinical symptom of the pathology is pain of lumbosacral location, the intensity of which on the visual analog scale in children corresponds to an average of 3.0 points. In adult patients with similar pathology, the average pain intensity measured with the same scale is 7.5 points. The most informative method for diagnosing the disease is computed tomography, which allows obtaining both 3D images and sections at the level of pseudarthrosis between the enlarged transverse process (or processes) of the suprasacral vertebra and the wing of the sacrum. To relieve pain in children with transitional vertebrae, both conservative and surgical methods are used. The most commonly used procedure is pseudarthrectomy. The study of long-term results one year after the intervention allowed us to record the absence of pain in children who underwent surgery. Prevention measures for transitional lumbosacral vertebrae have not been developed.Conclusion The analysis of the published literature shows that transitional vertebrae are a frequently diagnosed pathology in children and adolescents. Current methods of imaging are able to accurately detect not only the presence of the disease, but also to differentiate its type. The main clinical symptom of transitional vertebrae is pain in the lumbosacral spine which is difficult to relieve with conservative therapy. Pseudarthrectomy is the most frequent surgical method of treatment in children and adolescents that provides stable relief of vertebrogenic pain syndrome. Measures for specific prevention of the disease have not been developed.
Evolution of the first metatarsophalangeal joint replacement
Authors: Kotelnikov G. P. , Nikolaenko A. N. , Grankin I. O. , Ivanov V. V. , Isaykin P. Yu. , Doroganov S. O. , Zgirsky D. O. 
Published: April 2024

Introduction The diseases of the first metatarsophalangeal (1 MTP) joint that require surgical treatment include osteoarthritis (69 %), rheumatoid arthritis (26 %), tumors, tumor-like diseases and purulent arthritis (5 %). The treatment of arthritic 1 MTP is aimed at reducing pain and improving function. Joint replacement implants are meant to support body weight, maintain the length of the first metatarsal, provide metatarsal‑sesamoid joint functioning and restore joint motion. The purpose of the work was to analyze data from foreign and domestic literature on endoprosthetics of the 1 MTP, and briefly present analytical data on the results of using various implants.Material and methods The article presents the summary of the Russian and foreign publications on 1 MTP joint replacement. The original literature search was conducted on key resources including PubMed, eLIBRARY, MedLine, Scopus. The search strategy was comprised of keywords: “replacement of the first metatarsophalangeal joint”, “surgical treatment of hallux rigidus”, “osteoarthrosis of the first metatarsophalangeal joint”, “results of endoprosthetics of the 1st metatarsophalangeal joint”, "modernization of implants of the 1st metatarsophalangeal joint". Publications brought out between 1968 and 2022 inclusive were analyzed.Results and discussion The ideal implant should restore functional range of motion, improve function, maintain joint stability, distribute the stress across joint surfaces being wear-resistant. Over the years, various materials have been used to provide simple and reliable designs. Implants have been improved and divided into groups based on material and design, limited degrees of freedom, tribological pair composition, and the amount of articular surface replacement.Conclusion New generation implants have a more durable design, anatomical shape and improved osseointegration. The advances in joint replacement have resulted in greater patient satisfaction and increased service life. The complication rate for replacement of the 1 MTP joint remains high. This indicates the need for continued research and further work to improve implants to make them more effective and easier to use.
Effect of Melissa officinalis on Chemotherapy-Induced Peripheral Neuropathy in Cancer Patients: A Randomized Trial
Authors: Ehsani Zohreh , Salehifar Ebrahim , Habibi Emran , Alizadeh-Navaei Reza , Moosazadeh Mahmoud , Tabrizi Nasim , Zaboli Ehsan , Omrani-Nava Versa , Shekarriz Ramin 
Published: April 2024

Background: Chemotherapy-induced peripheral neuropathy (CIPN) is a significant cancer treatment side effect that can influence both quality of life and treatment course. Melissa Officinalis (MO), due to its high content of flavonoids, has antioxidant, anti-inflammatory, and neuroprotective properties.
Materials and Methods: The cancer patients diagnosed with CIPN attended a referral center in Sari (Iran). The hydroalcoholic extract of MO leaves was extracted by the maceration method. The control group received a placebo along with gabapentin as the standard treatment, and the intervention group received 500 mg Melissa officinalis 2 times daily for 3 months plus gabapentin. Patients were evaluated at the baseline and 3 months later, according to Common Terminology Criteria for Adverse Effects (CTCAE) and EORTC QLQ-C30 (Integrated System for Quality of Life Assessment).
Results: A total of 40 patients were considered as group D (intervention group), and 35 patients completed the study. Out of 40 subjects in the placebo group (P), 3 patients could not tolerate the drug due to gastrointestinal disturbances. The final values of CTCAE showed a statistically significant difference (p=0.010). Indicators related to the quality of life in both groups showed a significant improvement. In the intervention group, the pain perception and diarrhea experience were significantly reduced.
Conclusion: Quality of life indicators were improved by prescribing gabapentin with and without Melissa officinalis. The addition of Melissa officinalis to the chemotherapy regimen may improve diarrhea and pain perception.
Silibinin, Synergistically Enhances Vinblastine-Mediated Apoptosis in Triple Negative Breast Cancer Cell Line: Involvement of Bcl2/Bax and Caspase-3 Pathway
Authors: Dariushnejad Hassan , Roshanravan Neda , Wasman Hunar Mustafa , Cheraghi Mostafa , Pirzeh Lale , Ghorbanzadeh Vajihe 
Published: April 2024

Background: Triple-negative breast cancer (TNBC) with a poor prognosis and survival is the most invasive subtype of breast cancer. Usually, TNBC requires a chemotherapy regimen at all stages, but chemotherapy drugs have shown many side effects. We assumed that combination therapy of vinblastine and silibinin might reduce the vinblastine toxicity and dose of vinblastine.
Materials and Methods: The MDA-MB-231 were cells subjected to MTT assay for IC50 determination and combination effects, which were measured based on Chou-Talalay's method. The type of cell death was determined by using a Flow-cytometric assay. Cell death pathway markers, including Bcl-2, Bax, and caspase-3 were analyzed by western blot and Real-Time PCR.
Results: The treatment of MDA-MB-231 cells exhibited IC50 and synergism at the combination of 30 µM of silibinin and 4 µm of vinblastine in cell viability assay (CI=0.69). YO-PRO-1/PI double staining results showed a significant induction of apoptosis when MDA-MB-231 cells were treated with a silibinin and vinblastine combination (p<0.01). Protein levels of Bax and cleaved caspase-3 were significantly upregulated, and Bcl-2 downregulated significantly. Significant upregulation of Bax (2.96-fold) and caspase-3 (3.46-fold) while Bcl-2 was downregulated by 2-fold.
Conclusion: Findings established a preclinical rationale for the combination of silibinin and vinblastine. This combination produces synergistic effects in MDA-MB-231 cells by altering pro- and anti-apoptotic genes, which may reduce the toxicity and side effects of vinblastine.
Hemoglobin C Disorder in Anemic Patients Referred to the National Center for Thalassemia and Genetic Counseling in Damascus
Authors: Ahmad Aya , Fattoum Karam , Imam Wael , Mukhalalaty Mhd Yasser , Murad Musab , Al Quobaili Faizah Ali 
Published: April 2024

Background: Hemoglobinopathies are common inherited blood disorders in our Mediterranean area. The main structural hemoglobin variants are hemoglobin S and hemoglobin C, due to their prevalence.
We conducted this retrospective study to investigate and characterize hemoglobin C patients referred to the National Center for Thalassemia and Genetic Counseling and the management of hemoglobin C disease in Damascus.
Materials and Methods: The study included patients referred to the National Center for Thalassemia and Genetic Counseling in Damascus between 2000 and 2022 for hemoglobin C detection. Gender, age, geographical origin, hemoglobin electrophoresis profile, and blood transfusion were considered for hemoglobin C patient classification. Blood transfusion in five consecutive years and linear regression with hemoglobin S and C values were determined.
Results: 30 (14 males and 16 females) out of 624 patients between 3 and 46 years old (mean ± SD: 17.3 ± 9.7 years) showed hemoglobin C disease. Only eight patients (one male and seven females) received blood transfusions, and the remaining patients (13 males and 9 females) did not receive any transfusion. Only one patient with 100% hemoglobin C was detected; 19 showed HbSC, and 10 had HbAC. There was a significant correlation between hemoglobin S and geographical origin (P-value=0).
Conclusion: A Homozygote hemoglobin C patient has mild hemolytic anemia, whereas the hemoglobin C 100% patient has only a one-time blood transfusion (he was 17 years old) in our study. The inherited combination of hemoglobin C and S is less severe than hemoglobin S alone. There is a significant relationship between hemoglobin S and geographical origin (p-value=0).
The Role of Digitalization in Enhancing Legal Competencies of Sharia Economic Law Graduates: A Case Study of graduate users in South Kalimantan
Authors: Rahmaniah Amelia , Luthfi Fuad , Haris Muhammad 
Published: April 2024

Abstract: This study aims to identify the needs of graduate users and also show the strategies adopted by the Sharia Economic Law Study Program at Antasari State Islamic University in designing innovative curriculum and learning processes to produce graduate standards that are under the needs and desires of users. The informants in this study were graduate users who were selected based on the criteria of having alumni working in both government and non-government (private) agencies in South Kalimantan. The results showed that the needs of graduate users of the Sharia Economic Law Study Program include integrity, professionalism, foreign language skills, information technology skills, communication skills, cooperation skills, and self-development skills. In addition, the integration of technology in the learning process has also increased efficiency and effectiveness in transferring legal knowledge and skills to students.Keywords: Legal Competence, Sharia Economic Law, Graduate Users, Science Integration. Abstrak: Penelitian ini bertujuan untuk mengidentifikasi kebutuhan pengguna lulusan dan juga menunjukkan strategi yang ditempuh oleh Program Studi Hukum Ekonomi Syariah Universitas Islam Negeri Antasari dalam merancang kurikulum dan proses pembelajaran inovatif untuk menghasilkan standar lulusan yang sesuai dengan kebutuhan dan keinginan para pengguna. Informan dalam penelitian ini adalah para pengguna lulusan yang dipilih berdasarkan kriteria adanya alumni yang bekerja baik di instansi pemerintah dan non pemerintah (swasta) yang ada di Kalimantan Selatan. Hasil penelitian menunjukkan bahwa kebutuhan pengguna lulusan terhadap Program Studi Hukum Ekonomi Syariah meliputi integritas, profesionalisme, kemampuan bahasa asing, kemampuan teknologi informasi, kemampuan komunikasi, kemampuan kerjasama, dan kemampuan pengembangan diri. Selain itu, integrasi teknologi dalam proses pembelajaran juga telah meningkatkan efisiensi dan efektivitas dalam mentransfer pengetahuan dan keterampilan hukum kepada mahasiswa.Kata Kunci: Kompetensi Hukum, Hukum Ekonomi Syariah, Pengguna Lulusan, Integrasi Ilmu.
Legal Consequences For A Notary Public With Double Professions As A Rector Of A Private University Based On Law On Office Of Notary Public
Authors: Effendy Jaraputri Rabi'ah Adawiyah Phonna , Rahayu Sri Walny , Din Mohd. , Ghifari Muhammad Suhail 
Published: April 2024

Abstract: This research discusses juridical consequences for a notary with double professions as a rector of a private university according to Law on office of notary public. The purpose of this research is to explore and analyze the juridical consequences and sanctions for a notary with double professions as a rector or lecturer of a private university according to Law on office of notary public and code of ethics. This is normative legal research. This research shows that Article 17 Letter f of UUJN explicitly mentions the prohibition for a notary to has double professions as a manager or an employee of a State-owned Enterprise, a Municipally-owned Corporation, or a private company. A notary public who becomes a rector or lecturer at a private university is not assumed to violate the provision of Article 17 letter f UUJN. However, a notary with double professions can get administrative sanction in the form of a written warning, temporary layoff, honorably or dishonorably discharge.Keywords: Doubling for a notary; Rector of Private University Abstrak: Penelitian ini membahas mengenai konsekuensi yuridis bagi notaris yang merangkap jabatan sebagai pimpinan perguruan tinggi swasta menurut undang-undang jabatan notaris. Penelitian ini bertujuan untuk mengkaji dan menganalisis mengenai konsekuensi yuridis serta penerapan sanksi bagi notaris yang merangkap jabatan sebagai pimpinan atau dosen di perguruan tinggi swasta menurut undang-undang jabatan notaris dan kode etik. Jenis Penelitian ini ialah penelitian yuridis normatif. Hasil Penelitian menunjukkan bahwa dalam Pasal 17 huruf f UUJN secara eksplisit disebutkan bahwa adanya larangan bagi pengemban profesi Notaris untuk merangkap jabatan sebagai pemimpin atau pegawai BUMN, BUMD atau badan usaha swasta. Seseorang yang mengemban jabatan Notaris menjadi pimpinan dan dosen pada Perguruan Tinggi Swasta tidak melanggar ketentuan Pasal 17 huruf f UUJN. Serta terkait notaris yang melakukan rangkap jabatan dapat dikenakan sanksi administratif berupa peringatan tertulis, pemberhentian sementara, pemberhentian dengan hormat atau tidak hormat.Kata Kunci: Rangkap Jabatan Notaris, Pimpinan Perguruan Tinggi Swasta.
Self-Rated Health and Medically Diagnosed Chronic Disease Association among Adults in Puerto Rico
Authors: Gago Cristina , O’Neill H. June , Tamez Martha , López-Cepero Andrea , Rodríguez-Orengo José F. , Mattei Josiemer 
Published: April 2024

Introduction
Latinos report lower self-rated health (SRH) than non-Hispanic White persons. However, the association between SRH and medically diagnosed chronic diseases (MDCDs) remains understudied in Latino populations. This study assessed the relationship between a single-item SRH indicator and MDCD status among predominantly Latino adults in Puerto Rico.

Methods
Participants (30–75 years; n=965) of the Puerto Rico Observational Study of Psychosocial, Environmental, and Chronic Disease Trends (PROSPECT) reported SRH (excellent/very good, good, or fair/poor) and MDCD (ever vs never). We performed multivariate logistic regressions to evaluate the association between SRH and MDCD, which adjusted for key socioeconomic, demographic, and behavioral confounders.

Results
Twenty-seven percent of participants reported excellent/very good SRH, 39% good, and 34% fair/poor. Participants with fair/poor SRH (vs excellent/very good) were more likely to report MDCD for painful inflammation (odds ratio [OR]=4.95 [95% CI, 3.27–7.48]), kidney disease (4.64 [2.16–9.97]), sleep disorder (4.47 [2.83–7.05]), migraine headaches (4.07 [2.52–6.58]), overweight/obesity (3.84 [2.51–5.88]), depression (3.61 [2.28–5.74]), hypertension (3.59 [2.43–5.32]), high blood sugar (3.43 [2.00–5.89]), cardiovascular disease (3.13 [2.01–4.87]), anxiety (2.87 [1.85–4.44]), arthritis (2.80 [1.83–4.30]), diabetes (2.46 [1.57–3.83]), respiratory problems (2.45 [1.59–3.79]), stomach problems (2.44 [1.57–3.81]), eye disease (2.42 [1.44–4.06]), gallbladder disease (2.34 [1.35–4.05]), liver disease (2.26 [1.38–3.70]), heartburn (2.25 [1.55–3.26]), hyperlipidemia (2.10 [1.44–3.06]), and thyroid conditions (2.04 [1.30–3.21]).

Conclusions
SRH may reflect MDCD burden and serve as a valid screener to efficiently identify Latino individuals in high need of clinical services. This is relevant in Puerto Rico, where chronic disease rates remain high amid limited, disparate access to health care.
The Use of Navigators to Increase Patient Portal Enrollment among Patients in a Federally Qualified Health Care System
Authors: Matthews Alicia K. , Steffen Alana D. , Burke Larisa A. , Donenberg Geri , Duangchan Cherdsak , Akufo Jennifer , Opuada Hope , Oyaluade Damilola , Vilona Brittany Harris , Diaz Hilda , Dodd Darcy 
Published: April 2024

Purpose
To describe the training, preliminary results, and lessons learned from using patient navigators to increase the enrollment of low-income patients in a health system–supported and electronic health record–linked patient portal.

Methods
Patient navigators (n=4) were trained to assist patients in a federally qualified health center to enroll in and use patient portals. Patient navigators were stationed at 3 clinic locations. Data from the electronic health record system (Epic) were used to compare MyChart patient portal activation rates and use among patients for the 8 months before and after patient navigation services were offered.

Results
Navigators offered 83% of eligible patients with activation assistance. Sixty-four percent of the patients (n=1062) offered MyChart enrollment assistance accepted help. Seventy-four percent of assisted patients with no prior MyChart enrollment activated their accounts during that clinic visit. The primary reason for declining MyChart assistance was a lack of access to or comfort with technology. Patient portal activation increased during the 8 months when navigators were at the clinics (51%) compared to the previous 8 months (44%). Most new users viewed lab results and read a message [χ2(1)=49.3, p&lt;.001], with significant increases evident for African Americans [44% before, 49% during; χ2(1)=40.4, p&lt;.001] and Latinx patients [52% before, 60% during; χ2(1)=6.15, p=.013].

Conclusion
Study results suggest that using patient navigators is feasible and beneficial for increasing patient enrollment in the Federally Qualified Health Centers context. However, patient-, clinic-, and system-level factors were identified as barriers and should be addressed in future research studies.
Impacts of the Methylated Cyclodextrin KLEPTOSE® CRYSMEB on Inflammatory Responses in Human In Vitro Models
Authors: Truffin Damien , Marchand Flora , Chatelais Mathias , Chêne Gérald , Saias Laure , Herbst Frauke , Lipner Justin , King Alastair 
Published: April 2024

KLEPTOSE® CRYSMEB is a methylated cyclodextrin derivative displaying less methylated group substitution than randomly methylated cyclodextrin. It has demonstrated an impact on atherosclerosis and neurological diseases. linked in part to cholesterol complexation and immune response, but the impact on inflammatory cascade pathways was not clear. Thus, the impact of KLEPTOSE® CRYSMEB on various pharmacological targets was assessed using human umbilical vein endothelial cells in physiological and inflammatory conditions, followed by screening against twelve human primary cell-based systems designed to model complex human tissue and disease biology of the vasculature, skin, lung, and inflammatory tissues using the BioMAP® Diversity PLUS® Panel. Finally, the anti-inflammatory mechanism was investigated on peripheral blood mononuclear cells to evaluate anti-inflammatory or pro-resolving properties. The results showed that KLEPTOSE® CRYSMEB can modulate the immune system in vitro and potentially manage vascular issues by stimulating the expression of molecules involved in the crosstalk between immune cells and other cell types. It showed anti-inflammatory effects driven by pro-inflammatory cytokine secretion inhibition and could have different impacts on different tissue types. Moreover, this cyclodextrin showed no clear impact on pro-resolving lipid mediators. Finally, it appeared that the mechanism of action of KLEPTOSE® CRYSMEB seems to not be shared by well-known anti-inflammatory molecules.
Change of Natural Oscillation Frequencies of Buildings and Structures Depending on External Factors
Authors: Seleznev V.S. , Liseikin A.V. , Kokovkin I.V. , Soloviev V.M. 
Published: April 2024

Abstract
—This work is devoted to the development of the engineering seismic monitoring method created in Geophysical Survey of the Russian Academy of Sciences (GS RAS). In previous years, the “method of standing waves” was created and put into practice. It helps to separate natural oscillation modes of buildings and other engineering structures. The natural oscillations of hundreds of various objects (buildings, bridges, dams, etc.) had been studied and identified. We assumed that the physical condition of studied constructions could be controlled during exploitation by measuring the changes of natural oscillation frequencies. That would help to identify the appearance of defects in constructions, to prevent the risk of their destruction. However, it turned out that not everything is that simple: changes in frequency values are logically affected by changes in the environment around the studied objects. This article provides examples of these relations, influence of changes in environmental temperature, mass of objects and precipitation on the frequencies of natural oscillations.