bluuebunny/crossref_metadata_2025_split huggingface dataset:
Consumers’ level of patronage of halal business in Nigeria: Do religiosity and advertising matter?
Authors: Abdullahi Shafiu Ibrahim Ibrahim 
Published: June 2024

Purpose
The purpose of this paper is to measure the effects of religiosity and advertising on consumers’ patronage of halal industry in Nigeria.

Design/methodology/approach
Data for the study was collected using questionnaire survey. The collected data was analyzed using Tobit and ordered Logit models.

Findings
The findings of the work show that while the coefficient of religiosity is positive, but it is statistically insignificant, while advertising has a moderate negative effect on consumers’ patronage of halal business in Nigeria.

Practical implications
The study has implication on the use of advertising by halal business. It shows the limit of using advertisement to build brand; advertising shall be used together with other measures such as corporate social responsibility and other charitable undertakings.

Originality/value
To the best of the author’s knowledge, this work is the first of its kind that empirically tests the effect of advertising on patronage of halal business.
The optimal operation decision of gas station considering charging pile installation – conflict and coordination
Authors: Jiang Mingze , Jiang Minghui , Xue Jiaxin , Zhan Wentao , Liu Yuntao 
Published: June 2024

PurposeIn the construction of charging piles, traditional gas stations possess significant advantages in terms of regional and financial resources. The transformation of gas stations into “refueling+charging” integrated gas stations relies on charging pile manufacturers and government, involving coordination issues with them. This paper aims to propose a joint coordination contract based on the principles of cost-sharing and revenue-sharing. The objective is to achieve systemic coordination among integrated gas stations, charging pile manufacturers, and the government, optimizing the planning of the quantity of charging piles and charging prices.Design/methodology/approachWe have constructed an operational system model based on the Stackelberg game between charging pile manufacturers, integrated gas stations, and government. We have analyzed the optimal quantity of charging piles and charging prices under the impact of government subsidy policies in both decentralized and centralized operation scenarios. Additionally, we have proposed a joint coordination contract based on cost-sharing and revenue-sharing to coordinate this tripartite operational system.FindingsThe study reveals that, under simple cooperative contracts, the optimal decision does not yield maximum profits for the operational system due to the “double-marginal effect”. However, under the impact of the joint coordination contract, which combines cost-sharing and revenue-sharing as proposed in this paper, gas stations will consider the charging pile manufacturer’s costs and government subsidies when determining the optimal quantity and price. This not only achieves system coordination but also results in Pareto improvement in the benefits of all system members by adjusting contract parameters.Originality/valueThe value of this research lies in its insights into operational strategies for the construction of charging piles for electric vehicles. By analyzing optimal decisions under different contract arrangements, the study provides guidance to relevant stakeholders, enabling the operational system to achieve greater efficiency and coordination and realize more extensive Pareto improvements. Furthermore, it extends the application of coordination contract theory in the context of charging pile construction and operations.
“Difficulty mentioning the M word”: Perceptions of a woman disclosing negative menopause symptoms in the workplace
Authors: Daly Kara Lee , Pike Gemma , Clarke Victoria , Beck Vanessa 
Published: June 2024

PurposeThis qualitative study aims to explore general perceptions of a woman experiencing negative menopausal symptoms in the workplace. It examines the socio-cultural understandings informing the responses of a mixed participant group, including those unlikely to have experienced menopause, to a hypothetical scenario involving a woman disclosing negative menopausal symptoms in the workplace – to either a female or male manager.Design/methodology/approachUsing an innovative hybrid vignette-story completion (SC) technique, data were generated from 48 employees of a single UK-based organisation. Participants were presented with a vignette featuring a protagonist (Julie) experiencing negative menopausal symptoms, asked questions about their imaginings of Julie and how she might be perceived by others in the workplace, then presented with a story stem and asked to continue the story in the third person. The stem depicted Julie preparing to tell her manager about her symptoms and featured either a male or female manager, with one variation randomly presented to each participant. Responses were analysed using reflexive thematic analysis.FindingsThis study reports four themes: (1) the burden of menopause; (2) managing menopause at work; (3) menopause as not belonging in the workplace; and (4) menopause as unlocking new life potential? Limitations and directions for future research are discussed.Originality/valueUsing the innovative hybrid vignette-SC technique, this study contributes to the current discourse on menopause in the workplace by providing insight into how menopausal employees experiencing negative symptoms are perceived by others and the social understandings that shape these perceptions.
Tackling addictive behaviors through memory suppression: A scoping review and perspective
Authors: de Almeida‐Antunes Natália Alexandra , Sampaio Adriana Conceição Soares , Crego Manuel Alberto Barreiro , López‐Caneda Eduardo Guillermo 
Published: June 2024

AbstractForgetting is often viewed as a human frailty. However, over the years, it has been considered an adaptive process that allows people to avoid retrieval of undesirable memories, preventing them from suffering and discomfort. Evidence shows that the ability to suppress memories is affected by several psychopathological conditions characterized by persistent unwanted thoughts, including anxiety and posttraumatic stress disorders. Nevertheless, memory suppression (MS) mechanisms in addiction—a clinical condition characterized by recurrent drug‐related thoughts that contribute to repeated drug use—have received little attention so far. Addiction theories reveal that drugs change behavior by working on memory systems, particularly on declarative memory, which is related to the retrieval and encoding of drug‐related memories. In this review, the main behavioral and neurofunctional findings concerning the Think/No‐Think task—an adaptation of the classical Go/No‐Go tasks typically used to evaluate the suppression of motor response—are presented. We then show how the memory system can be involved in the craving or anticipation/preoccupation stage of the addiction cycle. Subsequently, the study of MS in the context of addictive behaviors is highlighted as a promising approach for gaining knowledge about the mechanisms contributing to the continuation of addiction. Finally, we discuss how interventions aiming to strengthen this ability could impact the anticipation/preoccupation stage by (i) reducing the accessibility of drug‐related memories, (ii) decreasing craving and attention toward drug‐related stimuli, and (iii) improving overall inhibition abilities. In conclusion, this review aims to illustrate how the study of MS may be a valuable approach to enhance our understanding of substance use disorders by unveiling the underlying cognitive and neural mechanisms involved, which could have important implications for addiction treatment.
Homozygous deleterious variants in the C‐terminal of TDRD5 impair spermiogenesis, causing severe oligoasthenoteratozoospermia in humans
Authors: Guo Rui , Ding Biao , Hu Kaiqin , Wang Kai , Tang Dongdong , Wang Xuegu , Sun Junpei , Li KuoKuo , Cheng Huiru , Xu Chuan , Sun Miao , Lu Likui , Liu Mingxi , Cao Yunxia , Yang Xiaoyu , He Xiaojin 
Published: June 2024

AbstractBackgroundPiRNA pathway factors, including evolutionarily conserved Tudor domain‐containing proteins, play crucial roles in suppressing transposons and regulating post‐meiotic gene expression. TDRD5 is essential for retrotransposon silencing and pachytene piRNA biogenesis; however, a causal link between TDRD5 variants and human infertility has not yet been established.ObjectiveTo identify the likely pathogenic variants of TDRD5 in infertile men, characterised by azoospermia or severe oligozoospermia.Material and methodsPotential candidate variants were identified and confirmed using whole‐exome and Sanger sequencing. Haematoxylin and eosin staining, immunofluorescence, and ultrastructural analyses were performed to investigate the structural and functional abnormalities of spermatozoa. The pathogenicity of the identified TDRD5 variants was verified using in vitro experiments. Functional effects of the C‐terminal nonsense variant were assessed via histology, immunofluorescence staining, and small‐RNA sequencing. Intracytoplasmic sperm injection (ICSI) was also performed to evaluate the efficacy of the clinical treatment.ResultsWe identified a homozygous missense variant (c.3043G > A, p.A1015T) and a homozygous nonsense variant (c.2293G > T, p.E765*) of TDRD5 in two unrelated infertile men. Both patients exhibited severe oligoasthenoteratozoospermia, characterised by the presence of spermatozoa with multiple heads and/or flagella, as well as acrosomal hypoplasia. In vitro experiments revealed that the p.A1015T variant caused a diffuse distribution of TDRD5 granules, whereas the p.E765* variant led to the production of a C‐terminal truncated protein with nuclear localisation, instead of the typical cytoplasmic localisation observed for the wild‐type protein. Functional investigations also revealed that truncation of the C‐terminal region of TDRD5 could potentially lead to a decline in the expression levels of intermitochondrial cement and chromatoid body components, such as MIWI (PIWIL1) and UPF1, and a slight decrease in the abundance of pachytene piRNA, ultimately resulting in compromised spermiogenesis. ICSI may be an effective treatment for these deficiencies.Discussion and conclusionThis study implicates TDRD5 as a novel candidate gene in the pathogenesis of human male infertility, emphasising the contribution of piRNA pathway genes to male infertility. In addition, our data suggest that ICSI could be a promising treatment for infertile men harbouring TDRD5 variants.
Review article: Hepatic steatosis and its associations with acute and chronic liver diseases
Authors: Koenig Aaron B. , Tan Albert , Abdelaal Hala , Monge Fanny , Younossi Zobair M. , Goodman Zachary D. 
Published: June 2024

SummaryBackgroundHepatic steatosis is a common finding in liver histopathology and the hallmark of metabolic dysfunction‐associated steatotic liver disease (MASLD), formerly known as non‐alcoholic fatty liver disease (NAFLD), whose global prevalence is rising.AimsTo review the histopathology of hepatic steatosis and its mechanisms of development and to identify common and rare disease associations.MethodsWe reviewed literature on the basic science of lipid droplet (LD) biology and clinical research on acute and chronic liver diseases associated with hepatic steatosis using the PubMed database.ResultsA variety of genetic and environmental factors contribute to the development of chronic hepatic steatosis or steatotic liver disease, which typically appears macrovesicular. Microvesicular steatosis is associated with acute mitochondrial dysfunction and liver failure. Fat metabolic processes in hepatocytes whose dysregulation leads to the development of steatosis include secretion of lipoprotein particles, uptake of remnant lipoprotein particles or free fatty acids from blood, de novo lipogenesis, oxidation of fatty acids, lipolysis and lipophagy. Hepatic insulin resistance is a key feature of MASLD. Seipin is a polyfunctional protein that facilitates LD biogenesis. Assembly of hepatitis C virus takes place on LD surfaces. LDs make important, functional contact with the endoplasmic reticulum and other organelles.ConclusionsDiverse liver pathologies are associated with hepatic steatosis, with MASLD being the most important contributor. The biogenesis and dynamics of LDs in hepatocytes are complex and warrant further investigation. Organellar interfaces permit co‐regulation of lipid metabolism to match generation of potentially toxic lipid species with their LD depot storage.
Pharmacokinetics of single‐dose rivaroxaban under fed state in obese vs. non‐obese subjects: An open‐label controlled clinical trial (RIVOBESE‐PK)
Authors: Alalawneh Majdoleen , Awaisu Ahmed , Abdallah Ibtihal , Elewa Hazem , Danjuma Mohammed , Matar Kamal M. , ElKashlan Akram M. , Elshayep Yasser , Ibrahim Fathy , Rachid Ousama 
Published: June 2024

AbstractThe evidence of rivaroxaban's pharmacokinetics in obese compared with non‐obese populations remains inconclusive. We aimed to compare the pharmacokinetic profile of rivaroxaban between obese and non‐obese populations under fed state. Participants who met the study's eligibility criteria were assigned into one of two groups: obese (body mass index ≥35 kg/m2) or non‐obese (body mass index 18.5–24.9 kg/m2). A single dose of rivaroxaban 20 mg was orally administered to each participant. Nine blood samples over 48 h, and multiple urine samples over 18 h were collected and analyzed for rivaroxaban concentration using ultra‐performance liquid chromatography coupled with tandem mass detector. Pharmacokinetic parameters were determined using WinNonlin software. Thirty‐six participants were recruited into the study. No significant changes were observed between obese and non‐obese participants in peak plasma concentration, time to reach peak plasma concentration, area under the plasma concentration–time curve over 48 h or to infinity, elimination rate constant, half‐life, apparent volume of distribution, apparent clearance, and fraction of drug excreted unchanged in urine over 18 h. Rivaroxaban's exposure was similar between the obese and non‐obese subjects, and there were no significant differences in other pharmacokinetic parameters between the two groups. These results suggest that dose adjustment for rivaroxaban is probably unwarranted in the obese population.
Effects of resistance training on muscle strength in adults with haemophilia: A systematic review and meta‐analysis
Authors: Núñez‐Cortés Rodrigo , Pérez‐Alenda Sofía , Calatayud Joaquín , Soto Verónica , Pinto Ronei S. , Andersen Lars Louis , Cruz‐Montecinos Carlos 
Published: June 2024

AbstractIntroductionAlthough resistance training is frequently prescribed for people with haemophilia (PWH), no previous meta‐analyses have quantified the effect of this intervention on muscle strength, nor the implications of the intervention's modality and duration.Aim(1) To determine the effects of resistance training on muscle strength in adults with haemophilia; (2) To determine the most effective duration and modality among the exercise protocols.MethodsA systematic search from inception until 28 November 2023 was conducted in PubMed, Embase, Web of Science, CENTRAL and CINAHL databases. We included randomised controlled trials or before‐after studies that involved resistance training without other physiotherapy co‐interventions. Study selection, data extraction and risk of bias assessment were independently performed by two reviewers. Disagreements were resolved in consultation with a third author. The level of evidence was determined according to the GRADE methodology.ResultsSeven studies were included. Measurements of knee extensor strength and elbow extensor strength were included in the meta‐analysis. Subgroup analysis showed significant effects for both elastic resistance protocols (SMD: 0.54; 95% CI: 0.02–1.07) and conventional training (isometric and weight‐based equipment) (SMD: 0.88; 95% CI: 0.50–1.25), demonstrating small and moderate effect sizes respectively. Additionally, both protocols of duration 5–7 weeks (SMD: 1.16, 95% CI: 0.63–1.69) as well as those of duration ≥8 weeks (SMD: 0.57, 95% CI: 0.20–0.94) showed a significant difference.ConclusionResistance training is effective in improving muscle strength of the knee and elbow extensors in PWH. Both elastic resistance and conventional training show benefits.
What aspects of health and wellbeing are most important to parent carers of children with disabilities?
Authors: McGlinchey Caomhan , Harniess Phillip , Borek Aleksandra J. , Garrood Alice , McDonald Annabel , Boyle Fleur , Logan Stuart , Morris Christopher 
Published: June 2024

AbstractIntroductionParent carers of children with special educational needs or disabilities are at risk of poorer health and wellbeing outcomes because of the distinct and challenging circumstances they face. Evaluations of interventions promoting the health of parent carers should focus on measuring the aspects of health and wellbeing which are most relevant to this group. As part of a programme of research on parent carer‐focused interventions, this study aimed to understand which aspects of health and wellbeing are perceived by parent carers as most meaningful and important.MethodsA qualitative study using semistructured online interviews was conducted. A purposive sample of parent carers was interviewed about relevant health and wellbeing outcomes. Transcripts were analysed thematically.ResultsThirty parent carers were interviewed, 19 of whom had experienced a health‐promoting intervention, either as participants (n = 14) or facilitators (n = 5). Three main themes were identified: ‘self, identity and beliefs’; ‘social connections and support’ and ‘health‐promoting practices and outcomes.’ Each theme encompassed the challenges participants faced, and the changes that helped them overcome these challenges. ‘Self‐identity’ challenges focused on the overwhelming nature of the parental care role and the emotional impact of this. Changes were brought about by developing a positive mindset, increasing confidence, and reconnecting with aspects of their identity which were important to them before they became parent carers. Challenges related to ‘social connections’ reflected parent carers' isolation. Change was brought about through increased peer support and peer interactions. Parent carers experienced challenges in terms of ‘health‐promoting activities’ because they lacked free time and experienced poor physical health. Changes were brought about by engagement in health‐promoting activities of various kinds.ConclusionParent carers view health and wellbeing in terms of overcoming the common challenges they face as a group. These challenges reflect the ways in which their physiological and psychological needs are often unmet. Researchers interested in measuring parent carer health and wellbeing should consider the specific challenges this group face, as well as theoretical frameworks which can make sense of these challenges, such as self‐determination theory.Patient or Public ContributionOur team carries out patient and public involvement (PPI) through a Family Faculty group facilitated by a Family Involvement Co‐ordinator (A. McD.) who is herself a parent carer. A study‐specific PPI working group was established which included members of the Family Faculty. The PPI group advised on various aspects of the research as reported in the paper. The manuscript was co‐authored by the team's Family Involvement Co‐ordinator (A. McD.).
Clinical spectrum of nasal involvement in cutaneous leishmaniasis
Authors: An İsa , Doni Nebiye Yentur 
Published: June 2024

AbstractBackgroundThe clinical appearance of cutaneous leishmaniasis (CL) lesions located in the nasal area can be confused with many inflammatory or tumoral diseases. In this study, we aimed to determine the frequency of nasal involvement and the morphological variants of CL lesions located in the nasal region.MethodsIn this retrospective study, we included patients who presented to our Skin and Venereal Diseases Clinic in the province of Şanlıurfa, located in the Southeastern Anatolia region of Turkey between September 2022 and October 2023, and were diagnosed with CL with nasal involvement. From the records of CL patients with nasal involvement in our clinic, we evaluated the clinical (lesion location, lesion type, lesion diameter, lesion duration, treatment) and demographic characteristics (age, gender).ResultsOf the patients (n = 278) diagnosed with CL using microscopic examination, 34 had nasal involvement, and the nasal involvement rate was 12.2%. Nineteen (55.8%) of the patients with nasal involvement were male, and 15 (44.2%) were female. Acute CL was detected in 28 patients (16 patients with dry‐type lesions, 12 patients with wet‐type lesions), and chronic CL was detected in six patients (four patients with lupoid and two patients with recidivant type lesions). According to the frequency distribution of clinical appearance, the most common lesions were eczema‐like lesions, erysipeloid‐type lesions, rhinophyma‐like lesions, and lymphoma‐like lesions.ConclusionPhysicians working in CL‐endemic regions should strictly consider CL in the differential diagnosis of nasal lesions. Early diagnosis and treatment of CL might prevent possible scarring and mucosal spread.
Accuracy of virtual articulation in maximal intercuspal position in direct and indirect digital workflows for fixed partial denture fabrication
Authors: Essam Yousra , El Kateb Mohammed , Morsy Noha 
Published: June 2024

AbstractPurposeTo assess the accuracy of virtual articulation in direct digital workflow (DDW) and indirect digital workflow (IDW) in arches prepared for fixed partial dentures (FPDs).Materials and MethodsFive pairs of master models were used in this study representing different clinical scenarios of full dentate (FD), and prepared arches for fixed partial dentures as follows: FD group, short span posterior (SSP group), long span posterior (LSP group), short span anterior (SSA group), and long span anterior (LSA). Fourteen pairs of interarch reference points were added to each set of master models to measure linear interarch distance with a caliper (reference measurements). The direct digital workflow included digital scans and virtual articulation with buccal scan images using an intraoral scanner. The indirect digital workflow included conventional polyvinylsiloxane impressions and bites followed by pouring, mounting, and scanning the stone models in a laboratory scanner. The scanned stone models were virtually articulated with buccal scanning in the laboratory scanner. Digital linear interarch measurements on all virtually‐articulated models were compared with reference measurements. The absolute mean differences in linear interarch distances were calculated. The Mann‐Whitney test was used for statistical analysis (α = .05).ResultsThe direct digital workflow produced significantly less linear interarch deviations in the virtually articulated models compared to the indirect digital workflow for all study groups (P < .05). However, the direct digital workflow had significantly less accuracy for virtual articulation in long span posterior, long span anterior, and short span anterior groups compared to the full dentate group. ConclusionsBoth workflows produced virtually‐articulated models with acceptable accuracy. However, the direct digital workflow had significantly better accuracy in all assessed clinical scenarios.