bluuebunny/crossref_metadata_2025_split huggingface dataset:
Temporal and Spatial Variability of the Electron Environment at the Orbit of Ganymede as Observed by Juno
Authors: Pelcener S. , André N. , Nénon Q. , Rabia J. , Rojo M. , Kamran A. , Blanc M. , Louarn P. , Penou E. , Santos‐Costa D. , Allegrini F. , Ebert R. W. , Wilson R. J. , Szalay J. , Mauk B. H. , Paranicas C. , Clark G. , Bagenal F. , Bolton S. 
Published: May 2024

AbstractThe thermal and energetic electrons along Ganymede's orbit not only weather the surface of the icy moon, but also represent a major threat to spacecraft. In this article, we rely on Juno plasma measurements to characterize the temporal and spatial variability of the electron environment upstream of Ganymede. In particular, we find that electron spectra observed by Juno have fluxes larger by a factor of 2–9 at energies above 10 keV than what was measured two decades earlier by Galileo. This result will advance our understanding of the surface weathering and may be a concern for the radiation safety of the JUICE mission. Furthermore, the June 2021 close fly‐by of Ganymede through the moon's wake reveals that the open field line regions of its magnetosphere attenuate electron fluxes at all energies by a factor of 1.6–5, thereby offering a natural shelter to visiting spacecraft crossing this region.
Periodic Oscillation of VLF Transmitter Signals Measured in Low and Middle Latitude Regions
Authors: Xu Wei , Feng Jingyuan , Gu Xudong , Ni Binbin , Wang Shiwei , Cheng Wen , Ma Wenchen , Xu Haotian , Pan Yudi 
Published: May 2024

AbstractMeasurements of Very Low Frequency (VLF) signals from navy transmitters carry direct information about the D‐region ionosphere and have been widely utilized for detecting the electron density at D‐region altitudes, but not frequently for the atmospheric waves therein. Atmospheric waves have been extensively studied using the total ionospheric electron content, but if and how they are correlated with the D‐region ionosphere and VLF measurements still remains poorly investigated. In this study, we have conducted a comprehensive analysis using 7‐year measurements (2016–2022) of VLF signals from the JJI, NWC, and VTX transmitters as being recorded in Suizhou, China. These three transmitter‐receiver paths are representative and the corresponding observations constitute a valuable data set to investigate the periodicities of VLF data. Different from previous studies, we have utilized the ensemble empirical mode decomposition and Lomb‐Scargle methods to determine the periodicities of these data. By contrasting these paths, prominent periodicities ranging from 2 to 730 days have been found, with clear diurnal variation and suggestive latitudinal/longitudinal dependence. Moreover, we have found that the mesospheric temperature is closely related with the annual oscillation of VLF measurements, while this oscillation has a low correlation with solar Lyman‐α fluxes or geomagnetic activity. The oscillations with relatively shorter periods are likely atmospheric waves such as gravity waves, planetary waves, or harmonics of these waves. Our results suggest that, in addition to the electron density, the subionospheric VLF technique can be potentially utilized to remotely sense atmospheric waves that propagate up to or through the D‐region ionosphere.
Sea Surface Temperatures Across the Coral Sea Over the Last Glacial‐Interglacial Cycle
Authors: Hollstein Martina , Kienast Markus , Lückge Andreas , Yokoyama Yusuke , Mohtadi Mahyar 
Published: May 2024

AbstractSea surface temperature (SST) across the Coral Sea is tightly coupled to the regional and larger‐scale ocean circulation and climate. Continuous records that reflect past changes in Coral Sea SST in high resolution are missing, however. Here, we present Mg/Ca‐ and alkenone‐based SST reconstructions from the northwestern Coral Sea that cover the past 130 kyr. Our SST estimates vary in line with southern hemisphere high latitude climate variability, linked to atmospheric CO2. Combining the newly generated with published records, we find that the SST changes across the Coral Sea show a large spatial heterogeneity during the last glacial‐interglacial cycle. Particularly prior to 60 ka, precession exerts a discernible influence on the meridional SST gradients across the Coral Sea, as well as between the Coral Sea and southern Western Pacific Warm Pool. We posit that these changes are linked to the regional trade winds and the South Pacific subtropical gyre circulation, and/or to changes in the El Niño Southern Oscillation.
A Comprehensive Northern Hemisphere Particle Microphysics Data Set From the Precipitation Imaging Package
Authors: King Fraser , Pettersen Claire , Bliven Larry F. , Cerrai Diego , Chibisov Alexey , Cooper Steven J. , L’Ecuyer Tristan , Kulie Mark S. , Leskinen Matti , Mateling Marian , McMurdie Lynn , Moisseev Dimitri , Nesbitt Stephen W. , Petersen Walter A. , Rodriguez Peter , Schirtzinger Carl , Stuefer Martin , von Lerber Annakaisa , Wingo Matthew T. , Wolff David B. , Wong Telyana , Wood Norman 
Published: May 2024

AbstractMicrophysical observations of precipitating particles are critical data sources for numerical weather prediction models and remote sensing retrieval algorithms. However, obtaining coherent data sets of particle microphysics is challenging as they are often unindexed, distributed across disparate institutions, and have not undergone a uniform quality control process. This work introduces a unified, comprehensive Northern Hemisphere particle microphysical data set from the National Aeronautics and Space Administration precipitation imaging package (PIP), accessible in a standardized data format and stored in a centralized, public repository. Data is collected from 10 measurement sites spanning 34° latitude (37°N–71°N) over 10 years (2014–2023), which comprise a set of 1,070,000 precipitating minutes. The provided data set includes measurements of a suite of microphysical attributes for both rain and snow, including distributions of particle size, vertical velocity, and effective density, along with higher‐order products including an approximation of volume‐weighted equivalent particle densities, liquid equivalent snowfall, and rainfall rate estimates. The data underwent a rigorous standardization and quality assurance process to filter out erroneous observations to produce a self‐describing, scalable, and achievable data set. Case study analyses demonstrate the capabilities of the data set in identifying physical processes like precipitation phase‐changes at high temporal resolution. Bulk precipitation characteristics from a multi‐site intercomparison also highlight distinct microphysical properties unique to each location. This curated PIP data set is a robust database of high‐quality particle microphysical observations for constraining future precipitation retrieval algorithms, and offers new insights toward better understanding regional and seasonal differences in bulk precipitation characteristics.
Sulfide Melt Wetting Properties in Earth's Mantle: New Constraints From Combined 2D and 3D Imaging
Authors: Beyer C. , Fonseca R. O. C. , Bissbort T. , Schröer L. , Cnudde V. 
Published: May 2024

AbstractBase‐metal sulfur liquids (mattes) play a crucial role as metasomatic agents and carriers of highly siderophile elements (HSE) within the Earth's mantle. Prior research has predominantly focused on sulfur‐poor metallic liquids involved in core formation scenarios. We conducted high‐pressure experiments using a multi‐anvil apparatus to investigate the effects of pressure, non‐ferrous compounds in mattes, and the mineral composition of the silicate host on matte wetting properties. Specifically, we explored conditions representing both the lithospheric (6 and 7 GPa) and sub‐lithospheric Earth's mantle (13 GPa). We characterized the experiments using the distribution of the dihedral angle in backscattered‐electron sections and the sphericity and network topology of the mattes in tomography scans. Our findings reveal distinct behaviors: while the matte in olivine‐dominated samples exhibited behaviors consistent with previous studies, such as high dihedral angle values (94° and 100°), the majorite‐bearing sample run at 13 GPa formed a disseminated network with a mean dihedral angle of 43°, below the connectivity threshold of 60°. Furthermore, in an experiment involving a garnet‐bearing silicate host, we observed a decrease in the matte's dihedral angle to 72°. Our results suggest that pressure within mafic hosts contributes to increased matte mobility in the sub‐lithospheric Earth's mantle, especially inasmuch as the stability of garnet phases is concerned. Consequently, mattes within subducted oceanic crusts may efficiently transport HSE into surrounding lithologies, while mattes within depleted, more harzburgitic lithologies and the ambient mantle may remain trapped within the silicate host at low melt fractions.
Unraveling the Light‐Absorbing Properties of Brown Carbon at a Molecular Level
Authors: Xu Nan , Hu Min , Li Xiao , Zeng Linghan , Wang Yujue , Qiu Yanting , Song Kai , Li Shuangde , Shuai Shijin , Chen Yunfa , Hu Jianlin , Guo Song 
Published: May 2024

AbstractBrown carbon (BrC) exhibits a highly complex chemical composition with diverse light‐absorbing properties, which complicates our understanding of its climate impacts. This study examined the impact of molecular characteristics (including molecular mass, unsaturation, oxidation state, and polarity) and heteroatoms on the light‐absorbing properties (absorptivity and wavelength dependence) of BrC from a molecular perspective, based on the ultraviolet‐visible spectra of over 40,000 light‐absorbing substances in aerosol from different sources and ambience. Our findings reveal that the light‐absorptivity of BrC molecules increases with decreasing polarity and O/C ratio, while it rises with higher molecular mass and unsaturation. We developed predictive models for molecular absorptivity based on its double bond equivalent and O/C ratio. In addition, we observed an inverse correlation between absorptivity and wavelength dependence at the molecular level, as determined through mathematical analysis. This molecular‐level understanding provides valuable insights into BrC absorbing mechanisms, facilitating more accurate characterization in atmospheric models.
Does cardiometabolic risk profile differ among individuals with traumatic and non-traumatic spinal cord injury (SCI): the evidence from the multicenter SCI cohort in Switzerland (SwiSCI)
Authors: Raguindin Peter Francis , Itodo Oche Adam , Eriks-Hoogland Inge , Muka Taulant , Brach Mirjam , Stucki Gerold , Stoyanov Jivko , Glisic Marija 
Published: May 2024

Abstract
Study design
Longitudinal study.

Objective
To explore whether individuals with traumatic spinal cord injury (TSCI) and non-traumatic SCI (NTSCI) experience different trajectories in changes of cardiometabolic disease (CMD) factors during initial rehabilitation stay.

Setting
Multicenter Swiss Spinal Cord Injury Cohort (SwiSCI) study.

Methods
Individuals without history of cardiovascular diseases were included. CMD factors and Framingham risk score (FRS) were compared between TSCI and NTSCI. Linear mixed models’ analysis was employed to explore the trajectory in CMD factors changes over rehabilitation period and a multivariate linear regression analysis was used at discharge from inpatient rehabilitation to explore factors associated with CMD risk profile in TSCI and NTSCI. We performed age and sex-stratified analyses.

Results
We analyzed 530 individuals with SCI (64% with TSCI and 36% NTSCI). The median age was 53 years (IQR:39-64) with 67.9% (n = 363) of the study cohort being male. The median rehabilitation duration was 4.4 months (IQR 2.4-6.4). At admission to rehabilitation, FRS (9.61 vs. 5.89) and prevalence of hypertension (33.16% vs. 13.62%), diabetes (13.68% vs. 4.06%), and obesity (79.05% vs. 66.67%) were higher in NTSCI as compared to TSCI, No difference was observed in cardiometabolic syndrome between the groups (around 40% in both groups). Overall, we observed longitudinal increases in total cholesterol, HDL-C and HDL/total cholesterol ratio, and a decrease in fasting glucose over the rehabilitation period. No differences in longitudinal changes in cardiovascular risk factors were observed between TSCI and NTSCI.

Conclusions
There was no deterioration in cardiometabolic risk factors over rehabilitation period, at discharge from initial rehabilitation stay. Both TSCI and NTSCI experienced high burden of cardiometabolic syndrome components with NTSCI experiencing more disadvantageous risk profile. The effectiveness of therapeutic and lifestyle/behavioral strategies to decrease burden of cardiometabolic disease and its components in early phase should be explored in future studies.
The cell cycle regulator p16 promotes tumor infiltrated CD8+ T cell exhaustion and apoptosis
Authors: Zhang Xin , Wang Jiajia , Tang Kun , Yang Yu , Liu Xiaowei , Yuan Shengtao , Guo Feng , Zhang Lianjun , Ma Kaili 
Published: May 2024

AbstractThe therapeutic efficacy of adoptive T cell therapy is largely restricted by reduced viability and dysfunction of CD8+ T cells. Continuous antigen stimulation disrupts the expansion, effector function, and metabolic fitness of CD8+ T cells, leading to their differentiation into an exhausted state within the tumor microenvironment (TME). While the function of the cell cycle negative regulator p16 in senescent cells is well understood, its role in T cell exhaustion remains unclear. In this study, we demonstrated that TCR stimulation of CD8+ T cells rapidly upregulates p16 expression, with its levels positively correlating with TCR affinity. Chronic TCR stimulation further increased p16 expression, leading to CD8+ T cell apoptosis and exhaustion differentiation, without inducing DNA damage or cell senescence. Mechanistic investigations revealed that p16 downregulates mTOR, glycolysis, and oxidative phosphorylation (OXPHOS) associated gene expression, resulting in impaired mitochondrial fitness, reduced T cell viability, and diminished effector function. Furthermore, the deletion of p16 significantly enhances the persistence of CD8+ T cells within tumors and suppresses the terminal exhaustion of tumor-infiltrating T cells. Overall, our findings elucidate how increased p16 expression reshapes T cell intracellular metabolism, drives T cell apoptosis and exhaustion differentiation, and ultimately impairs T cell anti-tumor function.
Ferroptosis: a potential bridge linking gut microbiota and chronic kidney disease
Authors: Mao Zi-Hui , Gao Zhong-Xiuzi , Pan Shao-Kang , Liu Dong-Wei , Liu Zhang-Suo , Wu Peng 
Published: May 2024

AbstractFerroptosis is a novel form of lipid peroxidation-driven, iron-dependent programmed cell death. Various metabolic pathways, including those involved in lipid and iron metabolism, contribute to ferroptosis regulation. The gut microbiota not only supplies nutrients and energy to the host, but also plays a crucial role in immune modulation and metabolic balance. In this review, we explore the metabolic pathways associated with ferroptosis and the impact of the gut microbiota on host metabolism. We subsequently summarize recent studies on the influence and regulation of ferroptosis by the gut microbiota and discuss potential mechanisms through which the gut microbiota affects ferroptosis. Additionally, we conduct a bibliometric analysis of the relationship between the gut microbiota and ferroptosis in the context of chronic kidney disease. This analysis can provide new insights into the current research status and future of ferroptosis and the gut microbiota.
Roles of long noncoding RNAs in human inflammatory diseases
Authors: Zhang Yuliang , Liu Hongliang , Niu Min , Wang Ying , Xu Rong , Guo Yujia , Zhang Chunming 
Published: May 2024

AbstractChemokines, cytokines, and inflammatory cells mediate the onset and progression of many diseases through the induction of an inflammatory response. LncRNAs have emerged as important regulators of gene expression and signaling pathways. Increasing evidence suggests that lncRNAs are key players in the inflammatory response, making it a potential therapeutic target for various diseases. From the perspective of lncRNAs and inflammatory factors, we summarized the expression level and regulatory mechanisms of lncRNAs in human inflammatory diseases, such as cardiovascular disease, osteoarthritis, sepsis, chronic obstructive pulmonary disease, asthma, acute lung injury, diabetic retinopathy, and Parkinson’s disease. We also summarized the functions of lncRNAs in the macrophages polarization and discussed the potential applications of lncRNAs in human inflammatory diseases. Although our understanding of lncRNAs is still in its infancy, these data will provide a theoretical basis for the clinical application of lncRNAs.
Changes in crystal morphology induced by lanthanide doping into diacetylene lamellar crystals
Authors: Kohri Michinari , Isomura Sojiro , Tachibana Kyoka , Hikichi Ryota , Oaki Yuya , Wadati Hiroki , Kanoh Hirofumi , Kishikawa Keiki 
Published: May 2024

AbstractIn this study, we show that doping lanthanides into lamellar crystals reorganizes the lamellar structure and dramatically changes the crystal morphology. Azo-DA, a compound with azobenzene derivatives and carboxylic acids at both ends of the diacetylene moiety, formed plate-like lamellar crystals. The doping of holmium (Ho), a lanthanide, into the film obtained by stacking Azo-DA lamellar crystals, promoted a dramatic change in crystal morphology, resulting in the formation of an Azo-DA/Ho film with a radial lamellar crystal structure. A detailed investigation of the crystal growth process revealed that Azo-DA/Ho, which is slightly formed in the solution phase during Ho doping, acts as a pseudonucleating agent and dramatically changes the morphology of the lamellar crystals. Additionally, the morphological changes in the lamellar crystal films significantly changed the surface properties of the films, such as their appearance and water repellency. Similar morphological changes in lamellar crystals were induced when other lanthanide elements were used instead of Ho, and the type of lanthanide dopant can affect the magnetic properties of the films.
A study on the early metabolic effects of salt and fructose consumption: the protective role of water
Authors: Hasbal Nuri Baris , Bakir Cicek Nur , Incir Said , Siriopol Dimitrie , Sanchez-Lozada Laura G. , Lanaspa Miguel A. , Johnson Richard J. , Kanbay Mehmet 
Published: May 2024

AbstractIncreasing serum osmolality has recently been linked with acute stress responses, which over time can lead to increased risk for obesity, hypertension, and other chronic diseases. Salt and fructose are two major stimuli that can induce acute changes in serum osmolality. Here we investigate the early metabolic effects of sodium and fructose consumption and determine whether the effects of sodium or fructose loading can be mitigated by blocking the change in osmolality with hydration. Forty-four healthy subjects without disease and medication were recruited into four groups. After overnight fasting, subjects in Group 1 drank 500 mL of salty soup, while those in Group 2 drank 500 mL of soup without salt for 15 min. Subjects in Group 3 drank 500 mL of 100% apple juice in 5 min, while subjects in Group 4 drank 500 mL of 100% apple juice and 500 mL of water in 5 min. Blood pressure (BP), plasma sodium, and glucose levels were measured every 15 min in the first 2 h. Serum and urine osmolarity, serum uric acid, cortisol, fibroblast growth factor 21 (FGF21), aldosterone, adrenocorticotropic hormone (ACTH) level, and plasma renin activity (PRA) were measured at the baseline and 2 h. Both acute intake of salt or fructose increased serum osmolality (maximum ∼4 mOsm/L peaking at 75 min) associated with a rise in systolic and diastolic BP, PRA, aldosterone, ACTH, cortisol, plasma glucose, uric acid, and FGF21. Salt tended to cause greater activation of the renin-angiotensin-system (RAS), while fructose caused a greater rise in glucose and FGF21. In both cases, hydration could prevent the osmolality and largely block the acute stress response. Acute changes in serum osmolality can induce remarkable activation of the ACTH-cortisol, RAS, glucose metabolism, and uric acid axis that is responsive to hydration. In addition to classic dehydration, salt, and fructose-containing sugars can activate these responses. Staying well hydrated may provide benefits despite exposure to sugar and salt. More studies are needed to investigate whether hydration can block the chronic effects of sugar and salt on disease.
Microbial adaptation to spaceflight is correlated with bacteriophage-encoded functions
Authors: Irby Iris , Broddrick Jared T. 
Published: May 2024

AbstractEvidence from the International Space Station suggests microbial populations are rapidly adapting to the spacecraft environment; however, the mechanism of this adaptation is not understood. Bacteriophages are prolific mediators of bacterial adaptation on Earth. Here we survey 245 genomes sequenced from bacterial strains isolated on the International Space Station for dormant (lysogenic) bacteriophages. Our analysis indicates phage-associated genes are significantly different between spaceflight strains and their terrestrial counterparts. In addition, we identify 283 complete prophages, those that could initiate bacterial lysis and infect additional hosts, of which 21% are novel. These prophage regions encode functions that correlate with increased persistence in extreme environments, such as spaceflight, to include antimicrobial resistance and virulence, DNA damage repair, and dormancy. Our results correlate microbial adaptation in spaceflight to bacteriophage-encoded functions that may impact human health in spaceflight.
Identifying proteomic risk factors for cancer using prospective and exome analyses of 1463 circulating proteins and risk of 19 cancers in the UK Biobank
Authors: Papier Keren , Atkins Joshua R. , Tong Tammy Y. N. , Gaitskell Kezia , Desai Trishna , Ogamba Chibuzor F. , Parsaeian Mahboubeh , Reeves Gillian K. , Mills Ian G. , Key Tim J. , Smith-Byrne Karl , Travis Ruth C. 
Published: May 2024

AbstractThe availability of protein measurements and whole exome sequence data in the UK Biobank enables investigation of potential observational and genetic protein-cancer risk associations. We investigated associations of 1463 plasma proteins with incidence of 19 cancers and 9 cancer subsites in UK Biobank participants (average 12 years follow-up). Emerging protein-cancer associations were further explored using two genetic approaches, cis-pQTL and exome-wide protein genetic scores (exGS). We identify 618 protein-cancer associations, of which 107 persist for cases diagnosed more than seven years after blood draw, 29 of 618 were associated in genetic analyses, and four had support from long time-to-diagnosis ( > 7 years) and both cis-pQTL and exGS analyses: CD74 and TNFRSF1B with NHL, ADAM8 with leukemia, and SFTPA2 with lung cancer. We present multiple blood protein-cancer risk associations, including many detectable more than seven years before cancer diagnosis and that had concordant evidence from genetic analyses, suggesting a possible role in cancer development.