bluuebunny/crossref_metadata_2025_split huggingface dataset:
Otitis externa in dogs (prevalence, etiology, clinical course, and treatment regimens)
Authors: Datsiuk D. L. , Hunchak V. M. , Gutyj B. V. , Khariv I. I. , Vasiv R. O. , Martynyshyn V. P. 
Published: June 2024

Otitis externa is a reasonably common problem in dogs. The most difficult is the treatment of recurrent chronic otitis media. After all, otitis externa in dogs is a polyetiological disease; therefore, to prescribe effective treatment, the doctor needs to identify the primary cause and take it under control, as well as identify and eliminate secondary infections and develop a prevention plan following predisposing factors. That is why a detailed analysis of the scientific literature on the distribution, etiology, clinical course, and scheme of treatment of dogs with the development of otitis externa was made. To ensure the accuracy and speed of diagnosis of otitis externa, it is promising to develop a diagnostic algorithm that will help the general practitioner clearly understand the etiological factors and eliminate them or take them under control. Many researchers have confirmed that otitis is characterized by seasonality (18.6 % occurs in summer, 30.2 % in autumn, 15.6 % in winter, and 35.6 % in spring). Depending on otitis's etiology in small domestic animals, microorganisms, fungi, and mites are decisive. According to the reports of some authors, otitis externa can be secondary; that is, the etiology of such pathology is already an infection (Staphylococcus and Pseudomonas bacteria, Malassezia yeast). Clinically, otitis externa in dogs, as a rule, is manifested by characteristic symptoms, while the existing peculiarities of the course are, in most cases, determined by etiological factors. In most cases, otitis externa is treated locally with drugs applied directly to the ear. Most of these products contain different ingredients that are active against bacteria, yeast, and inflammation at the same time. There are several remedies for the treatment of otitis externa at the veterinarian's choice, which require different treatment regimens. Recently, the practice of veterinary medicine has increasingly included complex drugs that, on the one hand, are effective in the treatment of otitis and, on the other hand, are safe for the animal body. Such drugs, as a rule, should show, at the same time, anti-inflammatory, anti-parasitic, anti-allergic, analgesic, immunomodulating, and other types of action. Because of this, the search and development of new drugs in the system of comprehensive measures for the prevention and treatment of inflammation of the external ear is relevant and promising.
Diseño e implementación de cápsulas educativas para facilitar el modelo “flipped classroom” en estudiantes vespertinos trabajadores de Chile
Authors: Donoso Gormaz Gonzalo 
Published: June 2024

En esta experiencia, se abordan el diseño y la implementación de cápsulas educativas destinadas a respaldar la metodología del flipped classroom en el contexto de estudiantes vespertinos trabajadores de una universidad privada en Chile. El interés surge de las altas tasas de reprobación y carencia de contexto en la asignatura de Matemática en estudiantes con años sin una educación formal continua y con deberes laborales en paralelo. El diseño experimental incluyó la creación de cápsulas educativas adaptadas a las necesidades de los estudiantes, considerando sus horarios, turnos y ritmos de estudio. La recopilación de datos se llevó a cabo mediante la implementación de las cápsulas educativas en un entorno educativo real, seguido de un análisis estadístico para evaluar la mejora en el rendimiento académico y la participación activa de los estudiantes. Los resultados revelaron beneficios significativos en términos de comprensión del contenido y participación en comparación con métodos tradicionales. A pesar de reconocer algunas limitaciones, este estudio proporciona una base sólida para la integración efectiva de cápsulas educativas en entornos educativos vespertinos, lo que respalda la implementación exitosa del modelo en este contexto específico.
PENGARUH LOKASI USAHA, KEMASAN PRODUK DAN PERSEPSI HARGA TERHADAP KEPUTUSAN PEMBELIAN
Authors: Widianto Galih Raka , Lukiarti Ming Ming 
Published: June 2024

Abstract: In this research, the problem examined is the influence of business location, product packaging and price perceptions on purchasing decisions for Ayam Geprek Pop Chicken Lasem consumers. The purpose of the researcher taking this title is to find out how big the independent variables are in relation to the dependent variable. In this research, the method that researchers used was accidental sampling as a research method. By using this method the researcher determined the criteria for respondents who could be the sample in this research, namely anyone who happened to meet the researcher could be used as a sample. The technique used in this research consists of multiple linear regression analysis tests using SPSS 23 tools. The results of the research prove that business location has an insignificant positive effect on purchasing decisions, while product packaging and price perceptions have a significant positive effect on purchasing decisions.

Keyword : Business location, product packaging, price perception, purchasing decisions

Abstrak: Pada penelitian ini permasalahan yang diteliti adalah mengenai pengaruh lokasi usaha, kemasan produk dan persepsi harga terhadap keputusan pembelian pada konsumen Ayam Geprek Pop Chicken Lasem. Tujuan mengapa peneliti mengambil judul tersebut adalah untuk mengetahui seberapa besar variabel-variabel independen terhadap variabel dependen. Pada penelitian ini metode yang peneliti gunakan adalah accidental sampling sebagai metode penelitian. Dengan menggunakan metode ini peneliti menetapkan kriteria responden yang dapat menjadi sampel dalam penelitian ini yaitu siapa saja yang secara kebetulan bertemu dengan peneliti dapat digunakan sebagai sampel. Teknik yang digunakan dalam penelitian ini terdiri dari uji analisis regresi linier berganda dengan alat bantu SPSS 23. Hasil penelitian membuktikan bahwa lokasi usaha berpengaruh positif tidak signifikan terhadap keputusan pembelian sedangkan kemasan produk dan persepsi harga berpengaruh positif signifikan terhadap keputusan pembelian.

Kata Kunci : Lokasi usaha, kemasan produk, persepsi harga, keputusan pembelian
Diagnosis of 7q11.23 deletion in a patient from Manaus, Amazonas with Williams-Beuren syndrome: Case report
Authors: Carvalho Natalia Dayane Moura , Prazeres Vania Mesquita Gadelha , Rezende Cleiton Fantin 
Published: June 2024

Williams-Beuren Syndrome is a rare disease caused by a chromosomal microdeletion in region 7q11.23. It is characterized as multisystemic, including intellectual and learning disabilities, distinct facial features, short stature, hypersocial behavior, and many malformations. Its diagnosis is traditionally clinical, but cytogenomic analyses such as fluorescence in situ hybridization can also be used for better etiological characterization of the syndrome. Our objective is to report the case of a boy in Manaus/Amazonas with Williams-Beuren Syndrome that presents a microdeletion in region 7q11.23. The patient is male, 12 years, of non-consanguineal parents, and no family history of hereditary diseases. The patient was sent for genetic testing after assessment of possible genetic syndrome, as the physical exams presented a gnome-like face, short nasal bridge, full lips, frequent smile, short stature, difficulty learning and atrioventricular dysplasia of valves with mild insufficiency and a cist in the left kidney. The results of the karyotype exam were normal and the fluorescence in situ hybridization revealed the microdeletion of region 7q11.23. Upon the follow-up, the subject was diagnosed with Williams-Beuren Syndrome. This microdeletion results in the loss of various genes that affect genic dosage/genic haploinsufficiency, resulting in a cytogenetic imbalance, consequently contributing to the patient’s phenotype. Therefore, the cytogenomic analysis was instrumental for the etiological diagnosis, in which microdeletion 7q11.23 was identified, allowing for proper diagnosis and prognosis, genetic counseling, and medical decisions, granting a better quality of life for the patient.
Influence of maternal body mass index on pregnancy complications and outcomes: a systematic review and meta-analysis
Authors: Zhang Yi , Lu Mei , Yi Ying , Xia Luming , Zhang Renjun , Li Chao , Liu Ping 
Published: June 2024

BackgroundThe prevalence of obesity among women of reproductive age is increasing worldwide, with implications for serious pregnancy complications.MethodsFollowing PRISMA guidelines, a systematic search was conducted in both Chinese and English databases up to December 30, 2020. Pregnancy complications and outcomes including gestational diabetes mellitus (GDM), gestational hypertension (GHTN), pre-eclampsia, cesarean section (CS), induction of labor (IOL), and postpartum hemorrhage (PPH) were analyzed. Random-effects or fixed-effects models were utilized to calculate the odds ratio (OR) with 95% confidence intervals (CIs).ResultsWomen with overweight and obesity issues exhibited significantly higher risks of GDM (OR, 2.92, 95%CI, 2.18-2.40 and 3.46, 95%CI, 3.05-3.94, respectively) and GHTN (OR, 2.08, 95%CI, 1.72-2.53 and 3.36, 95%CI, 2.81-4.00, respectively) compared to women of normal weight. Pre-eclampsia was also significantly higher in women with overweight or obesity, with ORs of 1.70 (95%CI, 1.44-2.01) and 2.82 (95%CI, 2.66-3.00), respectively. Additionally, mothers with overweight or obesity issues had significantly higher risks of CS (OR, 1.44, 95%CI, 1.41-1.47, and 2.23, 95%CI, 2.08-2.40), IOL (OR, 1.33, 95%CI, 1.30-1.35 and 1.96, 95%CI, 1.85-2.07), and PPH (OR, 1.67, 95%CI, 1.42-1.96 and 1.88, 95%CI, 1.55-2.29).ConclusionWomen with overweight or obesity issues face increased risks of pregnancy complications and adverse outcomes, indicating dose-dependent effects.
Performance of pitcher-type POU filters for the removal of 75 PFAS from drinking water: comparing different water sources
Authors: Teymoorian Termeh , Dinh Quoc Tuc , Barbeau Benoit , Sauvé Sébastien 
Published: June 2024

This study presents a comprehensive assessment of the performance of popular pitcher-type point-of-use (POU) water filters to remove PFAS contaminants from tap waters. The evaluated filters, Brita (Elite and Standard), ZeroWater, Aquagear, and ClearlyFiltered, were tested for their efficacy in removing 75 targeted PFAS, total organic carbon (TOC), total dissolved solids (TDS), chloride, and sulfate from two Canadian tap waters with background Σ75 PFAS concentrations of 13 and 56 ng/L. Overall, the performances of the filters varied depending on the structure of the filter media, the water source, and the specific contaminants present. ZeroWater was the top performer in the case of total PFAS removal. The volume-weighted average removal of total PFAS after 160 L of filtration using Saint-Donat tap water was 99% for ZeroWater, 99% for ClearlyFiltered, 77% for Aquagear, and 20% for Brita (Elite). In the case of Montreal tap water, which had different water characteristics and lower total PFAS levels, the volume-weighted average removal for PFAS was ≈100% for ZeroWater, 96% for ClearlyFiltered, 60% for Aquagear, 48% for Brita (Elite), and 38% for Brita (Standard). Both laboratory and home tests involving ZeroWater filters yielded similar high-performance results using Montreal tap water. Although ZeroWater exhibited high PFAS removal (99%) in Saint-Donat water, TDS and TOC desorption and a significant drop in pH were observed after 80 L, a phenomenon which was explained by the higher total concentration of anions in this water. In contrast, no desorption was observed in Montreal tap water for TDS and TOC due to the lower concentrations of anions. The Aquagear filter demonstrated an unusual increase in concentrations of sulfate after the initial 20 L, which needs further evaluation. This study discusses individual filter performance, the influence of tap water characteristics, and the potential to meet the new NSF guidelines, which provides valuable insights for consumers seeking to choose an appropriate easy-to-use water filtration system to ensure safe and clean drinking water in different regions.
Association of the oxidative balance score with sarcopenia among young and middle-aged adults: findings from NHANES 2011–2018
Authors: Cai Zhi , Dong Dantong 
Published: June 2024

BackgroundSarcopenia is associated with oxidative stress. The Oxidative Balance Score (OBS) is commonly used to assess dietary and lifestyle exposure to oxidative stress. However, few studies in the literature have assessed the correlation between sarcopenia and OBS.AimThis study aimed to assess the association between OBS and sarcopenia among young and middle-aged adults in the United States using data from the National Health and Nutrition Examination Survey (NHANES).MethodWeighted logistic regression analysis was used to investigate the association between OBS and sarcopenia based on data from NHANES 2011–2018. Subgroup analyses were performed to observe the consistency of the outcomes, and the stability of the results was tested using sensitivity analyses.ResultThe final sample included 5,525 young and middle-aged American adults. A higher OBS was associated with a lower risk of sarcopenia. In the fully adjusted model, the second (odds ratio [OR]: 0.62, 95% confidence interval [CI]: 0.41, 0.94; p = 0.023), third (OR: 0.50; 95% CI: 0.34, 0.74; p &lt; 0.001), and highest quartiles (OR: 0.18; 95% CI: 0.11, 0.28; p &lt; 0.001) of the OBS were associated with higher risks of sarcopenia when compared to the lowest quartile. This association was consistent across both dietary and lifestyle OBS scores. Our subgroup analysis revealed no significant differences between the subgroups of variables included in the interaction analysis. Sensitivity analyses revealed similar results.ConclusionOur study showed that higher antioxidant and lower antioxidant exposure may decrease the risk of developing sarcopenia. Higher OBS scores may indicate greater protection against sarcopenia; however, further clinical studies are warranted to confirm these findings.
Intensity-based optoretinography reveals sub-clinical deficits in cone function in retinitis pigmentosa
Authors: Gaffney Mina , Connor Thomas B. , Cooper Robert F. 
Published: June 2024

IntroductionClinical tools have been widely used in the diagnosis, description, and monitoring the progression of retinitis pigmentosa (RP); however, many of these methods have inherently low sensitivity and specificity, and significant photoreceptor disruption can occur before RP progression has clinically manifest. Adaptive optics scanning light ophthalmoscopy (AOSLO) has shown promise as a powerful tool for assessing photoreceptor disruption both structurally and functionally due to its increased resolution.MethodsHere we assess photoreceptor structure and function at the cellular level through AOSLO by acquiring intensity based optoretinography (iORG) in 15 individuals with no reported retinal pathology and 7 individuals with a prior clinical diagnosis of RP. Photoreceptor structure was quantified by calculating cone nearest neighbor distance (NND) across different retinal eccentricities from the AOSLO images. Cone outer segment length was measured across different retinal eccentricities using optical coherence tomography (OCT) derived longitudinal reflectivity profiles (LRPs). Finally, iORG measures of photoreceptor function were compared to retinal sensitivity as measured using the macular integrity assessment (MAIA) microperimeter.ResultsBroadly, participants with RP exhibited increasing cone nearest neighbor distances and decreasing cone outer segment length as a function of retinal eccentricity, consistent with prior reports for both controls and individuals with RP. Nearly all individuals with RP had reduced iORG amplitudes for all retinal eccentricities when compared to the control cohort, and the reduction was greater in eccentricities further from the fovea. Comparing iORG amplitudes to MAIA retinal sensitivity, we found that the iORG was more sensitive to early changes in photoreceptor function whereas MAIA was more sensitive to later stages of disease.DiscussionThis highlights the utility of iORG as a method to detect sub-clinical deficits in cone function in all stages of disease progression and supports the future use of iORG for identifying cells that are candidates for cellular based therapies.
Study protocol for “Psilocybin in patients with fibromyalgia: brain biomarkers of action”
Authors: Bornemann Julia , Close James B. , Ahmad Kirran , Barba Tommaso , Godfrey Kate , Macdonald Lauren , Erritzoe David , Nutt David , Carhart-Harris Robin 
Published: June 2024

BackgroundChronic pain is a leading cause of disability worldwide. Fibromyalgia is a particularly debilitating form of widespread chronic pain. Fibromyalgia remains poorly understood, and treatment options are limited or moderately effective at best. Here, we present a protocol for a mechanistic study investigating the effects of psychedelic-assisted-therapy in a fibromyalgia population. The principal focus of this trial is the central mechanism(s) of psilocybin-therapy i.e., in the brain and on associated mental schemata, primarily captured by electroencephalography (EEG) recordings of the acute psychedelic state, plus pre and post Magnetic Resonance Imaging (MRI).MethodsTwenty participants with fibromyalgia will complete 8 study visits over 8 weeks. This will include two dosing sessions where participants will receive psilocybin at least once, with doses varying up to 25mg. Our primary outcomes are 1) Lempel-Ziv complexity (LZc) recorded acutely using EEG, and the 2) the (Brief Experiential Avoidance Questionnaire (BEAQ) measured at baseline and primary endpoint. Secondary outcomes will aim to capture broad aspects of the pain experience and related features through neuroimaging, self-report measures, behavioural paradigms, and qualitative interviews. Pain Symptomatology will be measured using the Brief Pain Inventory Interference Subscale (BPI-IS), physical and mental health-related function will be measured using the 36-Item Short Form Health Survey (SF-36). Further neurobiological investigations will include functional MRI (fMRI) and diffusion tensor imaging (changes from baseline to primary endpoint), and acute changes in pre- vs post-acute spontaneous brain activity – plus event-related potential functional plasticity markers, captured via EEG.DiscussionThe results of this study will provide valuable insight into the brain mechanisms involved in the action of psilocybin-therapy for fibromyalgia with potential implications for the therapeutic action of psychedelic-therapy more broadly. It will also deliver essential data to inform the design of a potential subsequent RCT.
Portuguese cork industry: filling the knowledge gap regarding occupational exposure to fungi and related health effects
Authors: Viegas Carla , Dias Marta , Pacífico Cátia , Faria Tiago , Clérigo Anália , Brites Hermínia , Caetano Liliana Aranha , Carolino Elisabete , Gomes Anita Quintal , Viegas Susana 
Published: June 2024

IntroductionThe presence of the Penicillium section Aspergilloides (formerly known as Penicillium glabrum) in the cork industry involves the risk of respiratory diseases such as suberosis.MethodsThe aim of this study was to corroborate the predominant fungi present in this occupational environment by performing a mycological analysis of 360 workers’ nasal exudates collected by nasal swabs. Additionally, evaluation of respiratory disorders among the cork workers was also performed by spirometry.ResultsPenicillium section Aspergilloides was detected by qPCR in 37 out of the 360 nasal swabs collected from workers’ samples. From those, 25 remained negative for Penicillium sp. when using culture-based methods. A significant association was found between ventilatory defects and years of work in the cork industry, with those people working for 10 or more years in this industry having an approximately two-fold increased risk of having ventilatory defects compared to those working less time in this setting. Among the workers who detected the presence of Penicillium section Aspergilloides, those with symptoms presented slightly higher average values of CFU.DiscussionOverall, the results obtained in this study show that working in the cork industry may have adverse effects on worker’s respiratory health. Nevertheless, more studies are needed (e.g., using serological assays) to clarify the impact of each risk factor (fungi and dust) on disease etiology.
Overweight, Obesity, and Associated Risk Factors among Students at the Faculty of Medicine, Jazan University
Authors: Alqassimi Sameer , Elmakki Erwa , Areeshi Areej Siddiq , Aburasain Amani Baker Mohammed , Majrabi Aisha Hassan , Masmali Enas Mohammed Ali , Refaei Eman Adel Ibrahim , Mobaraki Raghad Abdu Ali , Qahtani Reem Mohammed A. , Oraibi Omar , Darraj Majid , Madkhali Mohammed Ali , Mohrag Mostafa 
Published: June 2024

Background and Objectives: This study aimed to determine the prevalence of overweight, obesity, and the associated risk factors among medical students at Jazan University in Saudi Arabia. Materials and Methods: A cross-sectional study was conducted among 228 medical students from their second to sixth academic years at the Faculty of Medicine, Jazan University. A self-administered questionnaire was used to collect data regarding sociodemographic characteristics, physical activity, dietary habits, comorbidities, medication use, family history, and lifestyle factors. Anthropometric measurements including height, weight, and waist circumference were recorded. Chi-square test and binary logistic regression were used to identify the risk factors associated with obesity. Results: The prevalence of overweight and obesity among the participants was 13.3% and 15%, respectively. Hence, the combined prevalence of overweight and obesity is 28.3%. The mean weight was 63.39 ± 18.93 kg, and the mean height was 163.48 ± 9.78 cm. On the other hand, 17.3% of participants were underweight, whereas 54.4% had normal BMI. Most of the participants (61%) did not engage in regular exercise. A high proportion consumed fruits (82.9%) and vegetables (58.8%) 3 or fewer days per week, and 84.2% consumed 3 or fewer meals per day. Fast-food consumption more than 3 days per week was reported by 42.1% of participants. Obesity was not significantly associated with sociodemographic factors, physical activity, dietary habits, comorbidities, medication use, or family histories. However, those with a monthly family income of SAR 15,000–24,999 had significantly lower odds of obesity than those in the lowest income group (OR 0.230, p = 0.045). Conclusions: The prevalence of overweight and obesity among medical students at Jazan University is high. Although no significant associations were found between obesity and most risk factors, this study highlights the need for interventions that promote healthy lifestyles among medical students. Further research is needed to identify effective strategies for preventing and managing obesity in this population.