bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pain perception is altered in patients with medication-overuse headache but can improve after detoxification
Authors: Munksgaard Signe Bruun , Bendtsen Lars , Jensen Rigmor Højland 
Published: July 2012

Abstract

Background
Previously, central sensitization has been found in chronic, primary headaches but pain perception in MOH patients has only scarcely been studied.

Aim
To investigate pain perception before and during detoxification in patients with medication overuse headache (MOH).

Methods
35 patients with MOH following structured detoxification programmes were tested before and 2, 6 and 12 months after withdrawal and 40 age and sex matched, healthy volunteers were tested for comparison. We measured cephalic and extra cephalic pressure pain thresholds (PPT) and supra-threshold pressure pain (STPP) as well as extra cephalic pain thresholds, supra-threshold pain and wind-up for electrical stimulation.

Results
At baseline, cephalic and extra cephalic PPTs were significantly lower in patients with MOH compared with healthy volunteers. Cephalic STPP was significantly higher in MOH patients compared with healthy volunteers but decreased significantly from baseline to the 6-month and 12-month follow-up. Supra-threshold pain for a single electrical stimulus was significantly higher in MOH patients compared with healthy volunteers. In contrast to healthy volunteers, patients with MOH did not exhibit wind-up before withdrawal. After 2 months, MOH patients had regained ability to wind-up and this persisted at 6-month and 12-month follow-up.

Conclusions
Patients with MOH have altered pain sensation and exhibit both allodynia and hyperalgesia indicating central sensitization. Withdrawal from medication overuse causes significant decrease in central sensitization. The ability to wind-up is altered in MOH patients, probably as a consequence of medication overuse, but it can be regained after withdrawal. These findings emphasize the need for detoxification in MOH.
Detoxification in a structured programme is effective for medication-overuse headache
Authors: Munksgaard Signe Bruun , Bendtsen Lars , Jensen Rigmor Højland 
Published: July 2012

Abstract

Aim
To evaluate the long-term efficacy of two different treatment programmes for medication-overuse headache (MOH) in so-called treatment-resistant patients.

Methods
MOH patients, who had previously been unsuccessfully treated by neurologists, were enrolled in one of 2 structured detoxification programmes in a tertiary headache centre: (A) a one-week withdrawal with restricted analgesics, rescue medications and prophylactics from Day 1 followed by advice of restricted intake of symptomatic medications or (B) a 2-month drug-free period and multidisciplinary education in groups and subsequent initiation of restricted symptomatic medication and prophylactics as required. All patients were closely followed up for a year.

Results
86 of 98 patients completed the 12-month follow-up. Totally, headache frequency was reduced by 39% (p <0.001), medication use by 63% (p <0.001) and 83% remained cured of MOH. Headache frequency was reduced with more than 50% in 42 patients (49%) and 52 (61%) reverted to episodic headache, and with no difference between the groups. Patients in programme B used significantly less symptomatic medication: 6.5 days/4 weeks compared with 8.7 days/4 weeks in programme A (p = 0.02), and the 56% of patients in programme B who needed prophylactic medication was significantly less than the 80% in programme A (p = 0.02). Further, programme B required fewer resources from the staff.

Conclusion
Structured detoxification with close follow-up by a multidisciplinary team for one year is highly effective in patients with previously treatment-resistant MOH. We recommend a multidisciplinary educational programme for patients in groups due to cost-effectiveness and limited use of medication.
Generation of internal waves from rest: extended use of complex coordinates, for a sphere but not a disk
Authors: Davis Anthony M. J. 
Published: July 2012

AbstractThe anisotropy created by stratification and or rotation places restrictions, severe if viscosity is present, on the construction of analytic solutions to wave generation and scattering problems. Consequently, much literature is devoted to frequency space and so careful consideration of oscillatory motion generated from rest is advisable. Moreover, the use of complex coordinates in the inviscid case has been incompletely presented. The detailed inversion of the Fourier time transform for a breathing or heaving sphere demonstrates an expanded, perhaps more crucial, role for the complex coordinates and shows that the known phase changes in the energy propagation regions are present throughout the St Andrew’s cross that circumscribes the sphere. However, the different solution structure for the heaving disk requires and allows a more direct calculation. Though the inclusion of rotation does not affect the dynamics, it enables the significance of their relative magnitude to be identified and reference to rotation only results achieved.
Breast-feeding duration: influence on taste acceptance over the first year of life
Authors: Schwartz Camille , Chabanet Claire , Laval Caroline , Issanchou Sylvie , Nicklaus Sophie 
Published: July 2012

Early feeding experiences, e.g. related to milk feeding, can affect later food and taste preferences. However, consequences of breast-feeding on taste acceptance are under-investigated. The objective of the present study was to examine the impact of exclusive breast-feeding duration (DEB) on taste acceptance at 6 and 12 months in the same infants (n122). Mothers recorded the DEB. Acceptance of solutions of each of the five basic tastes relative to water was evaluated in the laboratory at 6 and 12 months by the ingestion ratio (IR). Kendall correlations were calculated between the DEB and the IR. Only 16 % completed at least 6 months of exclusive breast-feeding; 79 % had begun complementary feeding by 6 months. At 6 months, infants preferred sweet, salty and umami solutions over water and were indifferent to sour and bitter solutions. The longer an infant was breast-fed, the more s/he accepted the umami solution at 6 months. At 12 months, infants preferred sweet and salty solutions over water and were indifferent to sour, bitter and umami solutions. The relationship between the DEB and acceptance of the umami solution was not observed at 12 months. No relationship was observed between the DEB and sweet, salty, sour and bitter taste acceptance at 6 or 12 months. The association between the DEB and umami taste acceptance at 6 months may relate to the higher glutamate content of human milk compared with formula milk. Beyond the acknowledged metabolic benefits of breast-feeding, this suggests that prolonged breast-feeding could also be associated with an impact on sensory preference at the beginning of complementary feeding.
Detrital zircon evidence for the linkage of the South China block with Gondwanaland in early Palaeozoic time
Authors: DUAN LIANG , MENG QING-REN , WU GUO-LI , MA SHOU-XIAN , LI LIN 
Published: July 2012

AbstractLA-ICP-MS U–Pb dating of Lower Devonian detrital zircon samples from three representative sections in the South China block yields dominant Grenvillian and Pan-African populations, similar to the age distribution of early Palaeozoic samples from Gondwana, the Tethyan Himalaya and West Australia, in particular. Hf isotopic compositions indicate the contributions of juvenile crust at 1.6 Ga and 2.5 Ga, and bear a resemblance to their counterparts from SE Australia and West Antarctica, revealing the mixed origin of the Pan-African and Grenvillian grains from juvenile magmas and melting of pre-existing crustal rocks. These results suggest that the South China block should be considered an integral part of East Gondwana in early Palaeozoic time, rather than a discrete continental block in the Palaeo-Pacific or a fragment of Laurentia.
Management of recurrent acute otitis media in children: systematic review of the effect of different interventions on otitis media recurrence, recurrence frequency and total recurrence time
Authors: Cheong K H , Hussain S S M 
Published: July 2012

AbstractObjective:To conduct a systematic review comparing the effect of three interventions (prophylactic antibiotics, tympanostomy tube insertion and adenoidectomy) on otitis media recurrence, recurrence frequency and total recurrence time.Methods:Literature on recurrent otitis media was identified using the PubMed and Scopus search engines for the period January 1990 to March 2011. A hand search of the reference lists of relevant articles and textbooks was conducted to identify additional studies. Randomised, controlled trials with a minimum of 40 children and follow up of at least 12 months were included.Results:Eighteen publications were identified. Each was assessed using preset inclusion criteria; seven publications met these criteria.Conclusion:Prophylactic antibiotics are effective in reducing otitis media recurrence, recurrence frequency and total recurrence time. Tympanostomy tube insertion failed to reduce the prevalence of otitis media recurrence, but reduced the recurrence frequency and total recurrence time. Adenoidectomy reduced otitis media recurrence; results on otitis media recurrence frequency differed but on average there was a reduction; however, the two studies with relevant data on total recurrence time had contradictory results.
Cirsoid aneurysm of the right pre-auricular region: an unusual cause of tinnitus managed by endovascular glue embolisation
Authors: Kumar A , Ahuja C K , Khandelwal N , Bakshi J B 
Published: July 2012

AbstractObjective:We report an interesting case of a right temporal pre-auricular arteriovenous fistula (cirsoid aneurysm) causing intractable tinnitus successfully managed by transarterial n-butyl cyanoacrylate glue embolisation.Case report:A 52-year-old female presented with a one-year history of tinnitus and pulsatile swelling in the right pre-auricular region. A colour Doppler ultrasound test and magnetic resonance angiography revealed a high-flow scalp arteriovenous fistula with a feeder vessel from the distal superficial temporal artery, which drained into the corresponding, dilated, tortuous vein. The patient underwent diagnostic digital subtraction angiography. This was followed by transarterial embolisation of the fistula using a 50 per cent mixture of n-butyl cyanoacrylate glue and Lipiodol®, with manual distal venous occlusion. A successful outcome was achieved with instant relief of symptoms.Conclusion:Cirsoid aneurysms of the facial region, an uncommon cause of tinnitus, can be effectively managed by endovascular embolisation. This treatment obviates the need for surgery, which is associated with an increased risk of complications such as scarring, deformity and bleeding.
Effects of the 2010 Chile and 2011 Japan tsunamis on the Antarctic coastal waters as detected via online mooring system
Authors: He Jianfeng , Zhang Fang , Lin Ling , Cai Minghong , Yang Haizhen , Wang Xiangnan 
Published: July 2012

AbstractSea level oscillations associated with both the 2010 Chile and 2011 Japan tsunamis were recorded in the coastal waters of King George Island off the west coast of Antarctica with an online coastal mooring system. The Chile tsunami arrived at the detection site within around five hours of the earthquake. The largest wave (84.4 mm) was measured 27 hours after the first arrival. In contrast, the Japan tsunami was detected around 26 hours after the earthquake, and the maximum wave height (180.8 mm) was observed around 11 hours after the initial wave. The energy level of the earthquake and the direction of energy propagation are probably the two most significant causes of the comparatively high amplitudes of the 2011 Japan tsunami, despite the fact that its epicentre was much further away than that of 2010 Chile tsunami. The sea level oscillations associated with the tsunami increased the level of mixing of seawater in the shallow Antarctic coastal waters and influenced the environment temporarily.
Complexity of Ising Polynomials
Authors: KOTEK TOMER 
Published: July 2012

This paper deals with the partition function of the Ising model from statistical mechanics, which is used to study phase transitions in physical systems. A special case of interest is that of the Ising model with constant energies and external field. One may consider such an Ising system as a simple graph together with vertex and edge weights. When these weights are considered indeterminates, the partition function for the constant case is a trivariate polynomialZ(G;x,y,z). This polynomial was studied with respect to its approximability by Goldberg, Jerrum and Paterson.Z(G;x,y,z) generalizes a bivariate polynomialZ(G;t,y), which was studied in by Andrén and Markström.We consider the complexity ofZ(Gt,y) andZ(G;x,y,z) in comparison to that of the Tutte polynomial, which is well known to be closely related to the Potts model in the absence of an external field. We show thatZ(G;x,y,z) is #P-hard to evaluate at all points in3, except those in an exceptional set of low dimension, even when restricted to simple graphs which are bipartite and planar. A counting version of the Exponential Time Hypothesis, #ETH, was introduced by Dell, Husfeldt and Wahlén in order to study the complexity of the Tutte polynomial. In analogy to their results, we give under #ETHa dichotomy theorem stating that evaluations ofZ(G;t,y) either take exponential time in the number of vertices ofGto compute, or can be done in polynomial time. Finally, we give an algorithm for computingZ(G;x,y,z) in polynomial time on graphs of bounded clique-width, which is not known in the case of the Tutte polynomial.
Quadricuspid aortic valve with ruptured sinus of Valsalva
Authors: Akerem Khan Shamruz Khan , Tamin Syahidah Syed , Burkhart Harold M. , Araoz Philip A. , Young Phillip M. 
Published: July 2012

AbstractWe present a case of a 24-year-old woman who was diagnosed with quadricuspid aortic valve with ruptured sinus of Valsalva. Quadricuspid aortic valve is a rare congenital cardiac anomaly. The recognition of quadricuspid aortic valve has clinical significance as it causes aortic valve dysfunction, and is often associated with other congenital cardiac abnormalities. We showed the important role of multimodality imaging in diagnosing a quadricuspid aortic valve associated with ruptured sinus of Valsalva.
Basic-Level Emergency Medical Technician Administration of Fluids and Glucose via Enzyme-Assisted Subcutaneous Infusion Access
Authors: Soremekun Olanrewaju A. , Shear Melissa L. , Connolly Jay , Stewart Charles E. , Thomas Stephen H. 
Published: July 2012

AbstractIntroductionDuring disasters and mass-casualty incidents (MCIs), there may be insufficient numbers of advanced life support (ALS) providers to provide intravenous (IV) access to all patients requiring parenteral fluids and/or medications. Enzyme-assisted subcutaneous infusion (EASI) access, in which human recombinant hyaluronidase (HRH) augments subcutaneous fluid dispersion and absorption, may be useful when ALS resources are insufficient to meet intravascular access needs. The utility of the use of the EASI lies, in part, in its ease of placement by ALS personnel.ObjectivesThe objectives of this study were to document the feasibility, comfort, and speed/degree of infused-glucose uptake through EASI lines placed by basic-level emergency medical technicians (EMT-Bs).MethodsEighteen EMT-Bs instituted EASI access on each other. A total of 150 units (1 mL) of HRH were administered through the EASI line, followed by the administration of 250 mL of tracer-labeled D5W. Timed phlebotomy enabled gas chromatography/mass spectrometry characterization of glucose uptake. Enzyme-assisted subcutaneous infusion placement and comfort ratings were tracked and analyzed using non-parametric statistics and Fisher's Exact Test.ResultsIn all 18 subjects, EASI access required only one attempt and was rated by the EMT-Bs as easy to accomplish. Glucose was absorbed quickly (within five minutes) in all subjects. The rate of infusion was rapid (median 393 mL/hour) and was comfortable for the recipients (median pain score 1/10).ConclusionsThe use of EASI may be viable as a fast, simple, and reliable method for the administration of fluid and glucose by EMT-Bs.Soremekun OA, Shear ML, Connolly J, Stewart CE, Thomas SH. Basic-level emergency medical technician administration of fluids and glucose via enzyme-assisted subcutaneous infusion access. Prehosp Disaster Med. 2012;27(3):1-6.
Differences in Medical Care Usage between Two Mass-Gathering Sporting Events
Authors: Burton James O. , Corry Stephen J. , Lewis Gareth , Priestman William S. 
Published: July 2012

AbstractBackgroundEvent planning for mass gatherings involves the utilization of methods that prospectively can predict medical resource use. However, there is growing recognition that historical data for a specific event can help to accurately forecast medical requirements. This study was designed to investigate the differences in medical usage rates between two popular mass-gathering sports events in the UK: rugby matches and horse races.MethodsA retrospective study of all attendee consultations with the on-site medical teams at the Leicester Tigers Rugby Football Club and the Leicester Racecourse from September 2008 through August 2009 was undertaken. Patient demographics, medical usage rates, level of care, as well as professional input and the effects of alcohol use were recorded.ResultsMedical usage rates were higher at the Leicester Racecourse (P < .01), although the demographics of the patients were similar and included 24% children and 16% staff. There was no difference in level of care required between the two venues with the majority of cases being minor, although a higher proportion of casualties at the Leicester Tigers event were seen by a health care professional compared with the Leicester Racecourse (P < .001). Alcohol was a contributing factor in only 5% of consultations.ConclusionsThese two major sporting venues had similar attendance requirements for medical treatment that are comparable to other mass-gathering sports events. High levels of staff and pediatric presentations may have an impact on human resource planning for events on a larger scale, and the separation of treatment areas may help to minimize the number of unnecessary or opportunistic reviews by the on-site health care professionals.BurtonJO, CorrySJ, LewisG, PriestmanWS. Differences in medical care usage between two mass-gathering sporting events. Prehosp Disaster Med.2012;27(4):1-5.
Independent Application of the Sacco Disaster Triage Method to Pediatric Trauma Patients
Authors: Cross Keith P. , Cicero Mark X. 
Published: July 2012

AbstractIntroductionThough many mass-casualty triage methods have been proposed, few have been validated in an evidence-based manner. The Sacco Triage Method (STM) has been shown to accurately stratify adult victims of blunt and penetrating trauma into groups of increasing mortality risk. However, it has not been validated for pediatric trauma victims.PurposeEvaluate the STM's performance in pediatric trauma victims.MethodsRecords from the United States’ National Trauma Data Base, a registry of trauma victims developed by the American College of Surgeons, were extracted for the 2007-2009 reporting years. Patients ≤18 years of age transported from a trauma scene with complete initial scene data were included in the analysis. Sacco triage scores were assigned to each registry patient, and receiver-operator curves were developed for predicting mortality, along with several secondary outcomes. Area under the receiver-operator curve (AUC) was the main outcome statistic. Sensitivity analysis was performed using a Sacco score without age adjustment, using blunt versus penetrating trauma, and using patients <12 years of age.ResultsThere were 210,175 pediatric records, of which 90,037 had complete data for analysis. The STM with age adjustment predicted pediatric trauma mortality with an AUC of 0.933 (95% CI: 0.925-0.940). Without the age adjustment term, it predicted mortality with an AUC of 0.924 (95% CI: 0.916-0.933). The STM with age adjustment predicted blunt trauma mortality in 72,467 patients with an AUC of 0.938 (95% CI: 0.929-0.947) and penetrating trauma mortality in 10,099 patients with an AUC of 0.927 (95% CI: 0.911-0.943). These findings did not change significantly when analysis was limited to patients <12 years of age. The Sacco Triage Method was also predictive of some secondary outcomes, such as major injury and death on arrival to the emergency department.ConclusionThe Sacco Triage Method, with or without its age adjustment term, was a highly accurate predictor of mortality in pediatric trauma patients in this registry database. This triage method appears to be a valid strategy for the prioritization of injured children.Cross KP, Cicero MX. Independent application of the Sacco Disaster Triage Method to pediatric trauma patients. Prehosp Disaster Med. 2012;27(4):1-6.
Traditional and Social Media Coverage and Charitable Giving Following the 2010 Earthquake in Haiti
Authors: Lobb Ano , Mock Nancy , Hutchinson Paul L. 
Published: July 2012

AbstractIntroductionMedia reports on disasters may play a role in inspiring charitable giving to fund post-disaster recovery, but few analyses have attempted to explore the potential link between the intensity of media reporting and the amount of charitable donations made. The purposes of this study were to explore media coverage during the first four weeks of the 2010 earthquake in Haiti in order to assess changes in media-intensity, and to link this information to data on contributions for emergency assistance to determine the impact of media upon post-disaster charitable giving.MethodsData on newspaper and newswire coverage of the 2010 earthquake in Haiti were gathered from the NexisLexis database, and traffic on Twitter and select Facebook sites was gathered from social media analyzers. The aggregated measure of charitable giving was gathered from the Center for Philanthropy at Indiana University. The intensity of media reporting was compared with charitable giving over time for the first month following the event, using regression modeling.ResultsPost-disaster coverage in traditional media and Twitter was characterized by a rapid rise in the first few days following the event, followed by a gradual but consistent decline over the next four weeks. Select Facebook sites provided more sustained coverage. Both traditional and new media coverage were positively correlated with donations: every 10% increase in Twitter messages relative to the peak percentage was associated with an additional US $236,540 in contributions, while each additional ABC News story was associated with an additional US $963,800 in contributions.ConclusionsWhile traditional and new media coverage wanes quickly after disaster-causing events, new and social media platforms may allow stories, and potentially charitable giving, to thrive for longer periods of time.Lobb A, Mock N, Hutchinson PL. Traditional and social media coverage and charitable giving following the 2010 earthquake in Haiti.Prehosp Disaster Med. 2012; 27(4):1-6.