bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evolving fill‐and‐spill patterns across linked early post‐rift depocentres control lobe characteristics: Los Molles Formation, Argentina
Authors: Privat Aurélia M‐L. J. , Peakall Jeff , Hodgson David M. , Schwarz Ernesto , Jackson Christopher A‐L. , Arnol Jonatan A. 
Published: June 2024

ABSTRACTInherited rift topography controls the sediment routing, timing of sand supply, and sedimentary linkage of early post‐rift depocentres. Exhumed examples of early post‐rift turbidite systems are rare and previous studies have examined the evolution of individual depocentres; in contrast, the detailed evolution of early post‐rift turbidite systems across multiple depocentres has never been documented. Current fill‐and‐spill models do not detail the stratigraphic architecture and evolution of sedimentological characteristics of multiple intraslope fans developed across topography, including bed type distributions. Here, the evolution of three intraslope fans that developed across two early post‐rift depocentres is documented along an 18 km long transect in the southern Neuquén Basin, Argentina. The relative chronology of sand supply in depocentres is constrained with new U–Pb ages, and sediment source areas with provenance analysis. The early post‐rift intraslope fans record progradation of the system and progressive sedimentary linkage of post‐rift depocentres, transverse to local syn‐rift structures, with sediment routing subparallel to the cratonic basin margin. The large‐scale stratigraphic architecture of intraslope fans indicates an evolution as a fill‐and‐spill system, with initial confinement through flow stripping and overspill to spillover with erosion and bypass across a transverse topographic high separating the depocentres. Changes in early post‐rift intraslope fan characteristics, including thickness, sandstone content, lobe complex stacking patterns, stratal termination patterns and bed type distribution, record changing confinement through time within a depocentre, and spatially across depocentres. The strong spatial and vertical stratigraphic variability of transitional flow deposits and hybrid event beds reflects enhanced erosion, sediment bypass and flow transformation across transverse relief between the two depocentres during the spillover phase. These findings advance current understanding of early post‐rift turbidite systems and refine fill‐and‐spill models, which will help the prediction of spatial and vertical changes in rock quality and connectivity in subsurface hydrocarbon reservoirs and CO2 storage sites.
Confidence intervals in monotone regression
Authors: Groeneboom Piet , Jongbloed Geurt 
Published: June 2024

AbstractWe construct bootstrap confidence intervals for a monotone regression function. It has been shown that the ordinary nonparametric bootstrap, based on the nonparametric least squares estimator (LSE) , is inconsistent in this situation. We show that an ‐consistent bootstrap can be based on the smoothed , to be called the SLSE (Smoothed Least Squares Estimator). The asymptotic pointwise distribution of the SLSE is derived. The confidence intervals, based on the smoothed bootstrap, are compared to intervals based on the (not necessarily monotone) Nadaraya Watson estimator and the effect of Studentization is investigated. We also give a method for automatic bandwidth choice, correcting work in Sen and Xu (2015). Analogous methods for constructing confidence intervals in the current status model are discussed, improving on work in Groeneboom and Hendrickx (2018).
Stop wasting time on mechanical weed control research that lacks a theoretical foundation
Authors: Rasmussen Jesper 
Published: June 2024

AbstractIn mechanical weed control research, there is a tendency to prioritise practical application over the establishment of a solid theoretical foundation. This emphasis can lead to a fragmented knowledge base and relatively modest research progress. The widespread use of ANOVA exacerbates this issue by primarily focusing on the differences between treatments, neglecting an exploration of the mechanisms behind the observed results. In response to these limitations and in line with rapid advances in sensor and robotics technology, this paper presents a proposal to establish a theoretical framework for mechanical weed control. The framework aims to emphasise understanding of the underlying mechanisms of mechanical weed control, rather than solely focusing on their observable outcomes. As part of this proposal, a simulation model known as HarrowSim based on regression parameters is presented. Simulation runs show the importance of factors such as treatment intensity, selectivity, crop tolerance and weed pressure in relation to crop yield response to post‐emergence weed harrowing. While currently parameterised for post‐emergence weed harrowing, it is argued that HarrowSim is relevant for all post‐emergence mechanical weed control methods, and is useful for teaching purposes and for inspiring future research. While the theoretical framework and HarrowSim have their weaknesses, these can also be perceived as opportunities since they can help focus attention on key issues for future research.
A High-Gain Observer Approach to Robust Trajectory Estimation and Tracking for a Multirotor Unmanned Aerial Vehicle
Authors: Boss Connor J. , Srivastava Vaibhav 
Published: June 2024

Abstract
Using the context of trajectory estimation and tracking for multirotor unmanned aerial vehicles (UAVs), we explore the challenges in applying high-gain observers to highly dynamic systems. The multirotor will operate in the presence of external disturbances and modeling errors. At the same time, the reference trajectory is unknown and generated from a reference system with unknown or partially known dynamics. We assume the only measurements that are available are the position and orientation of the multirotor and the position of the reference system. We adopt an extended high-gain observer (EHGO) estimation framework to estimate the unmeasured multirotor states, modeling errors, external disturbances, and the reference trajectory. We design a robust output feedback controller for trajectory tracking that comprises a feedback linearizing controller and the EHGO. The proposed control method is rigorously analyzed to establish its stability properties. Finally, we illustrate our theoretical results through numerical simulation and experimental validation in which a multirotor tracks a moving ground vehicle with an unknown trajectory and dynamics and successfully lands on the vehicle while in motion.
Aerobic Exercise as an Intervention for Mild Traumatic Brain Injury: A Critically Appraised Topic
Authors: Florez Makayla , Roberge Erin , Ostrowski Jennifer 
Published: June 2024

Clinical Scenario: As of 2020, the lifetime prevalence of at least one self-reported concussion is 24.6%. Athletic trainers in all settings work with patients who are at risk of sustaining a concussion or mild traumatic brain injury (mTBI) and developing persistent postconcussive symptoms. Aerobic exercise is emerging as an intervention for decreasing symptoms in patients who have sustained mTBI; however, the majority of research has been performed on pediatric patients. It is of interest whether aerobic exercise is an effective intervention for adult patients with mTBI. Focused Clinical Question: In adults who have sustained mTBI, does traditional therapy decrease symptoms more than aerobic exercise? Summary of Search: A systematic search of 4 databases was performed to answer this question. Three randomized controlled trials were identified that compared aerobic exercise to traditional therapy, which consists of physical and cognitive rest. Two studies found no significant differences in symptoms between the 2 groups while 1 study found decreased symptoms in the aerobic exercise group. Clinical Bottom Line: The current evidence is clear that there is no decrease in mTBI symptoms with traditional therapy as compared with aerobic exercise, with 1 study showing decreased symptoms with aerobic exercise. Strength of Evidence: Based on the Center for Evidence-Based Medicine grades of evidence, the clinical bottom line is based on grade A evidence.
Specific Contribution of the Transversus Abdominis for Postural Control Against Perturbation Caused by Kinesthetic Illusion
Authors: Akuzawa Hiroshi , Morito Tsuyoshi , Oshikawa Tomoki , Okubo Yu , Brumagne Simon , Kaneoka Koji 
Published: June 2024

Functional independence of the transversus abdominis (TrA) from other trunk muscles for postural control is still unclear. This study aimed to clarify the specific function of the TrA to control standing posture by vibratory stimulation of the triceps surae. Fifteen men participated in this study. Muscle activity of the TrA, internal oblique, lumbar multifidus, gluteus maximus, rectus femoris, biceps femoris, gastrocnemius, and tibialis anterior was measured using fine-wire and surface electrodes. Participants were asked to maintain a quiet standing posture with and without vibration of the triceps surae, which induced a kinesthetic illusion and the concomitant backward sway of the body. The muscle activity of each muscle for 10 s was extracted with and without vibration. The muscle activity levels were compared between the conditions by a paired t-test or Wilcoxon signed-rank test. The activity of the TrA and rectus femoris was increased, whereas the internal oblique showed no change as a result of the induced kinesthetic illusion. In addition, the activity of the multifidus and biceps femoris was decreased. The TrA and rectus femoris could contribute to control the backward sway of the body. Furthermore, the TrA may have functional independence from the internal oblique during standing postural control. These results warrant further study in patients with low back pain.
One Adventure after Another: Turning Challenges into Opportunities
Authors: Wilson* Frederic H. 
Published: June 2024

ABSTRACT
Born in Chicago, Illinois, I am a beneficiary of doors being opened during the 1960s. I was able to attend the University of Chicago Laboratory High School, and after high school, I attended Michigan Technological University. Thinking I’d like to become an architect, I enrolled in the civil engineering program. During orientation week, I discovered the geology department, and as my first class as a civil engineering major was Principles of Geology, it wasn’t long before the hook was set! However, I never really considered a career as a geologist after college because I assumed the draft and the Vietnam War would determine my ultimate fate. But I wasn’t drafted, and, ultimately, I took a job with Shell Oil Company in New Orleans as an “engineer,” though I had a geology degree. Realizing this was not the job I wanted or the place I wanted to be, I sought an adventure by going to the University of Alaska to get a master’s degree. This led to many more adventures and challenges as I learned to adapt to a new environment far different from my past experience. As I finished the master’s degree, I was invited to join the U.S. Geological Survey (USGS) and began a long career with the Alaska group of the USGS. It, too, has been one continuing adventure, working with and learning from some amazing people through the years. I only hope that others can find their way to their own adventures in the geosciences. There have been barriers thrown up along the way at times, sometimes reflecting that I’m African American. Yet, in all cases, I’ve found ways to adapt or overcome. My style has been to get along, but sometimes I’ve needed to push through barriers to accomplish my goal at the time.
Disseminated nocardiosis presenting as a superinfected thyroglossal duct cyst in a patient with diabetes
Authors: Schmid Anouk , Ahmad Nader , Haubitz Sebastian , Speth Marlene Maria 
Published: June 2024

We introduce the case of a male patient in his 60s who was admitted to our emergency department with a persisting sore throat for the last 3 weeks and dysphagia. Fibre-endoscopic evaluation revealed an asymmetry at the base of the tongue. In combination with elevated white cell count and C reactive protein, a computerized tomography showed a superinfected thyroglossal duct cyst. Intravenous antibiotics were initiated, and the patient was taken to the operating room for cervicotomy. The microbiological swab taken intraoperatively detectedNocardia paucivorans. Additional imaging revealed disseminated nocardiosis with cerebral and pulmonary manifestations.The patient was treated with oral trimethoprim/sulfamethoxazole and, over time, showed complete remission of central nervous system lesions and improvement of pulmonary involvement. Following this, the treatment was stopped 8 months after the initial diagnosis. In this report, we discuss treatment standards and outcomes of nocardiosis based on our management strategies of our patient.
Primary pure squamous cell carcinoma of the gallbladder
Authors: Burke Cynthia Elaine , Wong William G , Khouzam Simone , Ruggiero Francesca M , Vining Charles C 
Published: June 2024

SummarySquamous cell carcinoma (SCC) is an uncommon and frequently aggressive subtype of gallbladder cancer known for its poor outcomes compared with other gallbladder tumours. Gallbladder SCC typically presents as higher grade and more advanced than adenocarcinoma, resulting in lower estimated survival. Early recognition of these tumours is ideal, but infrequently achieved. Herein is a case of a male patient in his 80s with new onset abdominal pain who was initially diagnosed with cholecystitis, but diagnostic imaging revealed a gallbladder mass. Surgical resection and pathology revealed pure SCC of the gallbladder without local organ invasion or metastatic disease. Pure SCC histology of the gallbladder is rare, with limited studies on clinical presentation, natural history, and optimal treatment.
Abstract PO-018: Commensal bacteria are required for chronic inflammation and B lymphoma development in myeloid cell-specific TRAF3-deficient mice
Authors: Jung Jaeyong , Zhu Sining , Lalani Almin I , Shakarchi Judith , Wu Guojun Gary , Zong Wei-Xing , Zhao Liping , Xie Ping 
Published: June 2024

Abstract
Myeloid cells are the major players of innate immunity and inflammation. The function of myeloid cells is critically regulated by the adaptor protein TRAF3. We previously reported that aging myeloid cell-specific TRAF3-deficient (M-Traf3-/- ) mice spontaneously develop chronic inflammation and B-cell lymphoma (BCL). Here we sought to identify the internal trigger of chronic inflammation and aberrant B cell activation in these mice. We first detected gut dysbiosis and transmigration of commensal bacteria to the liver in aging M-Traf3-/- mice using 16s rRNA gene sequencing of fecal bacterial DNA and bacterial culture of liver homogenates, respectively. To determine if gut dysbiosis and bacterial transmigration induce chronic inflammation and aberrant B cell activation, we treated mice with broad-spectrum antibiotics. We found that depletion of commensal bacteria with antibiotics effectively prevented chronic inflammation and BCL development in aging M-Traf3-/- mice. We next demonstrated that systemic IgG responses against commensal bacteria were induced in the mice as shown by fecal bacteria FACS analysis. Interestingly, our sequencing data of the IgH gene VDJ region revealed that many malignant B cell clones of M-Traf3-/- mice had undergone class switch recombination and contained somatic hypermutations, indicating their origination from germinal center (GC) or post-GC B cells. We also noticed that the CDR3 sequences of malignant B cell clones derived from M-Traf3-/- mice exhibit high homology to prevalent bacteria-reactive Ig clonotypes. Furthermore, aging M-Traf3-/- mice with BCL contained high titers of antibodies against commensal bacteria, but not autoantigens, in the serum. Taken together, our findings suggest that commensal bacteria dysbiosis and transmigration can promote chronic inflammation and BCL development in individuals with compromised innate immunity. Accordingly, inhibition of commensal bacteria may serve as an effective therapeutic strategy for the prevention and treatment of chronic inflammation and B-cell lymphomas in these patients.
Citation Format: Jaeyong Jung, Sining Zhu, Almin I Lalani, Judith Shakarchi, Guojun Gary Wu, Wei-Xing Zong, Liping Zhao, Ping Xie. Commensal bacteria are required for chronic inflammation and B lymphoma development in myeloid cell-specific TRAF3-deficient mice [abstract]. In: Proceedings of the Fourth AACR International Meeting on Advances in Malignant Lymphoma: Maximizing the Basic-Translational Interface for Clinical Application; 2024 Jun 19-22; Philadelphia, PA. Philadelphia (PA): AACR; Blood Cancer Discov 2024;5(3_Suppl):Abstract nr PO-018.
Analysis of the effect of superselective ophthalmic artery thrombolysis for central retinal artery occlusion
Authors: Kang Ningyu , Xue Yan , Wang Fei , Guan Qingliang , Li Min 
Published: June 2024

Introduction To investigate the clinical efficacy of superselective ophthalmic artery thrombolysis for central retinal artery occlusion (CRAO).
Methods Retrospective study of CRAO patients who attended the Department of Ophthalmology of Affiliated Hospital of Weifang Medical University from January 2022 to July 2023, 138 CRAO patients with onset time of 1-3 days were selected for the study. Among them, 86 patients refused thrombolytic treatment and chose to adopt traditional treatment, which was categorized as the control group; 52 patients adopted superselective ophthalmic artery thrombolytic treatment, which was categorized as the observation group. The visual acuity of the patients treated with traditional modality on the 4th day after the onset of the disease and the visual acuity of the patients treated with superselective ophthalmic artery thrombolysis on the 1st postoperative day were recorded, and the visual acuity improvement after different modalities of treatment was compared between the two groups.
Results In the control group, 77 (89.5%) of the treated patients had no improvement in visual acuity, 9 (10.5%) had improvement, 0 (0.0%) had significant improvement, and the total improvement was 9 (10.5%); in the observation group, 18 (34.6%) of the treated patients had no improvement in visual acuity, 21 (40.4%) had improvement, 13 (25.0%) had significant improvement, and the total improvement was 34 (65.4%). The total improvement rate of treatment in the observation group was 65.4%, which was significantly higher than the 10.5% in the control group, and the difference was statistically significant (P&lt;0.05).
Conclusion Superselective ophthalmic artery thrombolysis for patients with CRAO is clinically effective, promotes improvement in patient vision, and has a high safety profile.
TRAUMA KIMIA MATA YANG DISEBABKAN POTASSIUM PERMANGANAT (KMNO4)
Authors: Amajida Saraya , Ayu Niluh Putu , Octaviany Efi , Natan Priscilla Christina 
Published: June 2024

Pendahuluan: Trauma kimia mata adalah kegawatdaruratan yang sering pada anak-anak. Trauma mata disebabkan oleh senyawa asam maupun basa. Salah satu penyebab trauma kimia pada mata yang jarang ditemui adalah Potassium Permanganat (KMnO4). Laporan kasus ini bertujuan untuk mendeskripsikan tatalaksana trauma kimia mata yang disebabkan Potassium Permanganat di PMN RS Mata Cicendo Bandung.
Laporan Kasus: Seorang anak laki-laki berusia 3 tahun datang ke Instalasi Gawat Darurat (IGD) Rumah Sakit Mata Cicendo dengan keluhan nyeri, merah dan bengkak pada mata kiri. Pasien terkena cairan KMNO4 ketika sedang bermain 10 jam sebelum masuk ke rumah sakit. Pemeriksaan visus pada mata kanan 6/6 sedangkan mata kiri sulit untuk diperiksa. Terdapat bengkak pada kelopak mata atas dan bawah, senyawa KMnO4 melekat kuat pada konjungtiva tarsal dan konjungtiva bulbi. Kornea keruh dan tes bayangan positif.
Diskusi: Pasien didiagnosa dengan Trauma Kimia Ropper Hall derajat II OS. Pasien diirigasi dengan 2 liter cairan salin normal sampai mencapai pH 7. Pasien dilakukan transplantasi membran amnion dan debridemen permukaan mata dalam anestesi. Tatalaksana fase awal kasus ini adalah irigasi. Terapi definitif memerlukan pembedahan untuk mempercepat proses penyembuhan. Komplikasi yang sering terjadi adalah defisiensi sel limbus kornea, mata kering, simblepharon, glaukoma sekunder, dan katarak.
Kesimpulan: Penanganan yang cepat dan agresif diperlukan dalam kasus-kasus seperti ini untuk untuk mendapatkan penyembuhan yang lebih baik.
KARAKTERISTIK PASIEN DIABETES MELLITUS YANG MENGIKUTI PROGRAM SKRINING RETINOPATI DIABETIK BERBASIS KOMUNITAS DI KOTA BANDUNG OLEH RUMAH SAKIT MATA CICENDO PADA TAHUN 2022
Authors: Effendy Varrel Geary Effendy , Rini Mayang , Ratnaningsih Nina , Irfani Irawati , Natalya Susanti 
Published: June 2024

Pendahuluan: Retinopati diabetik merupakan komplikasi mikrovaskular yang diakibatkan oleh penyakit diabetes mellitus kronis. Retinopati diabetik memerlukan skrining sebagai deteksi dini untuk mengontrol keparahannya.
Metode: Penelitian ini bertujuan untuk mengetahui karakteristik pasien retinopati diabetik yang terjaring skrining oleh Rumah Sakit Mata Cicendo pada tahun 2022 serta kelompok yang rentan yang mengalami retinopati diabetik. Karakteristik pasien dikategorikan menjadi karakteristik demografi, klinis, dan status oftalmologis. Desain penelitian ini berupa studi deskriptif potong lintang menggunakan data kuesioner skrinining pasien yang dilakukan pada tahun 2022.
Hasil: Rumah sakit mata cicendo berhasil melakukan skrining terhadap 435 pasien. Data yang terkumpul menunjukkan pasien yang mengikuti skrining mayoritas perempuan (71,49%), berusia 60-79 tahun (64,6%), memiliki riwayat hipertensi (66,44%), dan memiliki durasi diabetes 5-10 tahun (42,99%). Prevalensi DR dan VTDR dari pasien diabetes mellitus yang mengikuti skrining adalah 20,23% dan 3,68%. Mayoritas pasien berjenis kelamin perempuan (21,54%), kelompok umur 40-59 tahun (23,36%), memiliki riwayat hipertensi (20,76%), memiliki riwayat dislipidemia (22,22%) dan durasi diabetes 5-10 tahun (25,13%) mengalami retinopati diabetik.
Kesimpulan: Retinopati diabetik rentan terjadi pada orang dengan jenis kelamin perempuan, umur 40-59 tahun, riwayat hipertensi, riwayat dislipidemia, dan durasi diabetes 5-10 tahun.