bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dengue haemorrhagic fever in chronic kidney disease and heart failure: challenges in fluid management
Authors: Vidanapathirana Manudi 
Published: April 2024

AbstractDengue haemorrhagic fever (DHF) is recognized to have high mortality in patients with chronic kidney disease (CKD) and heart failure (HF). They are at high risk of shock during the ascending limb of the critical phase of DHF, fluid overload during convalescence and bleeding throughout the entire illness. Physiological changes and medications used in CKD/HF make the diagnosis and monitoring of DHF difficult. Treatment with standard fluid regimens also poses a challenge due to the propensity for fluid overload. As a result, standard dengue guidelines do not provide recommendations on fluid management regimens in DHF with CKD/HF. This article provides a narrative review on the existing evidence for management of DHF in patients with volume-changed states such as HF, CKD and nephrotic/ nephritic syndromes. It will explore the relevant diagnostic and therapeutic dilemmas, acknowledge the challenges for developing guidelines and recommend strategies to improve fluid management in these groups of patients.
Fluoroscopically calibrated 3D-printed patient-specific instruments improve the accuracy of osteotomy during bone tumor resection adjacent to joints
Authors: Wang Chen , Huang Siyi , Yu Yue , Liang Haijie , Wang Ruifeng , Tang Xiaodong , Ji Tao 
Published: April 2024

Abstract
Background
Inadequate surface matching, variation in the guide design, and soft tissue on the skeletal surface may make it difficult to accurately place the 3D-printed patient-specific instrument (PSI) exactly to the designated site, leading to decreased accuracy, or even errors. Consequently, we developed a novel 3D-printed PSI with fluoroscopy-guided positioning markers to enhance the accuracy of osteotomies in joint-preserving surgery. The current study was to compare whether the fluoroscopically calibrated PSI (FCPSI) can achieve better accuracy compared with freehand resection and conventional PSI (CPSI) resection.

Methods
Simulated joint-preserving surgery was conducted using nine synthetic left knee bone models. Osteotomies adjacent to the knee joint were designed to evaluate the accuracy at the epiphysis side. The experiment was divided into three groups: free-hand, conventional PSI (CPSI), and fluoroscopically Calibrated PSI (FCPSI). Post-resection CT scans were quantitatively analyzed. Analysis of variance (ANOVA) was used.

Result
FCPSI improved the resection accuracy significantly. The mean location accuracy is 2.66 mm for FCPSI compared to 6.36 mm (P < 0.001) for freehand resection and 4.58 mm (P = 0.012) for CPSI. The mean average distance is 1.27 mm compared to 2.99 mm (p < 0.001) and 2.11 mm (p = 0.049). The mean absolute angle is 2.16° compared to 8.50° (p < 0.001) and 5.54° (p = 0.021). The mean depth angle is 1.41° compared to 8.10° (p < 0.001) and 5.32° (p = 0.012). However, there were no significant differences in the front angle compared to the freehand resection group (P = 0.055) and CPSI (P = 0.599) group. The location accuracy observed with FCPSI was maintained at 4 mm, while CPSI and freehand resection exhibited a maximum deviation of 8 mm.

Conclusion
The fluoroscopically calibrated 3D-printed patient-specific instruments improve the accuracy of osteotomy during bone tumor resection adjacent to joint joints compared to conventional PSI and freehand resection. In conclusion, this novel 3D-printed PSI offers significant accuracy improvement in joint preserving surgery with a minimal increase in time and design costs.
Cholestatic liver injury secondary to over-the-counter cyproheptadine: case report and review of literature
Authors: Agarwal Ayush , Shastri Arpit , Ganesh C. P. , Shastri Malvika , Mitra Suvradeep , Ray Debadrita , De Arka 
Published: April 2024

Abstract
Background
Cyproheptadine is an easily available over-the-counter first-generation antihistaminic that is often used as an appetite stimulant. Although it is usually a safe drug, rare instances of drug-induced liver injury may occur.

Case presentation
We report a case of cholestatic liver injury secondary to cyproheptadine in a young pharmacy student with chronic hepatitis B and review the literature of cyproheptadine-induced liver injury.

Conclusion
Although cyproheptadine is largely a safe drug, its potential for significant liver toxicity cannot be ignored.
INTERNACIONALIZAÇÃO DE BIOJOIAS
Authors: Silva Givan Aparecido Fortuoso da , Martins Adriana de Souza , Oliveira Érica Santos , Silva Márcia Joviano da 
Published: April 2024

Analisar se a sociobiodiversidade brasileira contribui para a inserção dos produtores de biojoias no mercado internacional corresponde ao objetivo geral deste estudo. Como objetivos específicos tem-se verificar quais fatores da sociobiodiversidade brasileira contribuem para agregação de valor para os produtores de biojoias ingressarem no mercado internacional; averiguar se a inserção das biojoias brasileiras no mercado internacional contribui para a formação de cadeias produtivas de interesses dos povos e das comunidades tradicionais e de agricultores familiares; e constatar se a produção de biojoias por povos e comunidades tradicionais colabora para a manifestação da cultura popular e de sua capacidade criativa. A pesquisa qualitativa de caráter exploratório fez uso de um roteiro de entrevista para a coleta de dados. Os resultados demonstram que, mais que contribuir para a inserção das biojoias no mercado internacional, a sociobiodiversidade reiterou valores sociais, culturais e econômicos, ajudando na diversificação das peças e aumentando as oportunidades para os produtores.
Detection and analysis of serum bile acid profile in patients with colonic polyps
Authors: Ji Xin , Chen Hong 
Published: April 2024

BACKGROUND
Analyzing the variations in serum bile acid (BA) profile can provide a certain biological basis for early warning and prevention of various diseases. There is currently no comprehensive study on the relationship between the serum BA profile and colonic polyps.
AIM
To study the serum BA profile detection results of patients with colonic polyps, and analyze the correlation between BA and colonic polyps.
METHODS
From January 1, 2022, to June 1, 2023, 204 patients with colonic polyps who were diagnosed and treated at Zhongda Hospital Southeast University were chosen as the study subjects, and 135 non-polyp people who underwent physical examination were chosen as the control group. Gathering all patients' clinical information, typical biochemical indicators, and BA profile.
RESULTS
Compared with the control group, the serum levels of taurocholic acid, glycocholic acid, glycochenodeoxycholic acid, and taurochenodeoxycholic acid in the colonic polyp group were significantly higher than those in the control group, while the content of deoxycholic acid (DCA) was lower than that in the control group (P < 0.05). When colonic polyps were analyzed as subgroups, it was shown that there was a strong correlation between changes in the BA profile and polyp diameter, location, morphology, pathological kind, etc.
CONCLUSION
The serum BA profile showed significant changes in patients with colonic polyps, with a significant increase in primary conjugated BA content and a decrease in secondary free bile acid DCA content. There is a certain correlation between primary free BA and pathological parameters of polyps.
Relationship between clinical belonging, professional identity, and nursing information ability among nursing interns: Model construction
Authors: Zhang Gai , Huang Shao-Juan , Li Shu-Fang 
Published: April 2024

BACKGROUND
Clinical belonging refers to the feeling that clinical medical staff feel recognized and accepted by others or groups. The level of clinical belonging of nursing interns affects students’ learning motivation and confidence, which in turn affects their clinical practice behavior.
AIM
To explore the effects of professional identity and nursing information ability on clinical belonging among nursing interns and establish a relationship model for these factors.
METHODS
The researchers used the convenience sampling method to select 682 nursing interns from China. The survey was conducted using a general information questionnaire, clinical sense of belonging scale, nursing information ability self-assessment scale, and a nursing student professional identity questionnaire. The mediating effect of nursing information ability between their professional identity and clinical sense of belonging was analyzed using SPSS 21.0 and the path analysis in structural equation modeling.
RESULTS
The total scores of clinical belonging, professional identity, and nursing information ability of nursing interns were (104.29 ± 13.11) points, (57.89 ± 7.16) points, and (70.29 ± 6.20) points, respectively. Nursing information ability had a direct effect on the clinical sense of belonging (effect value = 0.46, P < 0.05). Occupational identity had a direct effect (effect value = 0.52, P < 0.05) and an indirect effect (effect value = 0.21, P < 0.05) on clinical belonging.
CONCLUSION
Nursing administrators in nursing colleges and hospitals should take effective measures to improve the professional identity and nursing information ability of nursing interns, as well as the clinical sense of belonging among nursing interns.
Rim 18F-fluorodeoxyglucose uptake of hepatic cavernous hemangioma on positron emission tomography/computed tomography: A case report
Authors: Hu Yong-An , Guo Ya-Xin , Huang Qi-Feng 
Published: April 2024

BACKGROUND
Peripheral FDG accumulation in a hepatic hemangioma presenting in a patient with prolonged fever is rare. Therefore, clinicians should pay close attention to patients with hepatic mass.
CASE SUMMARY
A 54-year-old woman with a 4-wk history of daily fevers was admitted to our hospital. A whole body 18F-Fluordesoxyglucose (PET-FDG) positron emission tomography/computed tomography (PET/CT) was performed to elucidate the source of the fever. However, whole body 18F-FDG PET/CT raised the suspicion of a malignant lesion because of peripheral FDG accumulation (SUVmax 3.5 g/mL) higher than that of the normal liver parenchyma (SUVmax 1.6 g/mL) surrounding a hypoactive area, and no other abnormalities were showed. Subsequently, the patient underwent liver mass resection. Histopathology showed a hepatic cavernous hemangioma with fatty infiltration around the lesion. The fever disappeared four days after surgery and the patient did not present any complications during follow-up.
CONCLUSION
Fatty infiltration in the peripheral parts of hepatic cavernous hemangioma may lead to subacute inflammation which further activate the Kupffer cells. This may cause prolonged fever and peripheral rim FDG accumulation on PET/CT.
Recovering from prolonged cardiac arrest induced by electric shock: A case report
Authors: Zhang Jian , Qiao Yan-Ru , Yang Ya-Dong , Pan Guo-Zheng , Lv Chong-Qing 
Published: April 2024

BACKGROUND
Cardiac arrest (CA) induced by electric shock is a rare occurrence, particularly in cases of prolonged CA. Currently, there is limited literature on similar incidents, and we present a relevant case report.
CASE SUMMARY
A 27-year-old Asian male man, experiencing respiratory CA due to electric shock, was successfully restored to sinus rhythm after 50 min of cardiopulmonary resuscitation and 8 electrical defibrillation sessions. In the subsequent stages, the patient received multiple organ function protection measures, leading to a successful recovery and eventual discharge from the hospital.
CONCLUSION
Prolonging resuscitation time can enhance the chances of survival for patients, this study provide valuable insights into the management of electric shock-induced CA.
Refractory autoimmune hemolytic anemia in a patient with systemic lupus erythematosus and ulcerative colitis: A case report
Authors: Chen Dai-Xing , Wu Yue , Zhang Sui-Feng , Yang Xiao-Jun 
Published: April 2024

BACKGROUND
Ulcerative colitis (UC) and systemic lupus erythematosus (SLE) are both systemic immunoreactive diseases, and their pathogenesis depends on the interaction between genes and environmental factors. There are no reports of UC with SLE in China, but six cases of SLE with UC have been reported in China. The combination of these two diseases has distinct effects on the pathogenesis of both diseases.
CASE SUMMARY
A female patient (30 years old) came to our hospital due to dull umbilical pain, diarrhea and mucous bloody stool in August 2018 and was diagnosed with UC. The symptoms were relieved after oral administration of mesalazine (1 g po tid) or folic acid (5 mg po qd), and the patient were fed a control diet. On June 24, 2019, the patient was admitted for treatment due to anemia and tinnitus. During hospitalization, the patient had repeated low-grade fever and a progressively decreased Hb level. Blood tests revealed positive antinuclear antibody test, positive anti-dsDNA antibody, 0.24 g/L C3 (0.9-1.8 g/L), 0.04 g/L C4 (0.1-0.4 g/L), 32.37 g/L immunoglobulin (8-17 g/L), and 31568.1 mg/24 h total 24-h urine protein (0-150 mg/24 h). The patient was diagnosed with SLE involving the joints, kidneys and blood system. Previously reported cases of SLE were retrieved from PubMed to characterize clinicopathological features and identify prognostic factors for SLE.
CONCLUSION
The patient was discharged in remission after a series of treatments, such as intravenous methylprednisolone sodium succinate, intravenous human immunoglobulin, cyclophosphamide injection, and plasma exchange. After discharge, the patient took oral prednisone acetate tablets, cyclosporine capsules, hydroxychloroquine sulfate tablets and other treatments for symptoms and was followed up regularly for 1 month, after which the patient's condition continued to improve and stabilize.
Condição digital e desigualdades educacionais
Authors: DIAS VANINA , Rodrigues Ione , Rodrigues Ione 
Published: April 2024

Este ensaio visou analisar em que aspectos a necessidade de uso, quase que obrigatório das Tecnologias Digitais da Informação e Comunicação durante a pandemia da Covid-19, potencializou as desigualdades já presentes no acesso aos recursos tecnológicos e virtuais para estudantes brasileiros e ainda de que forma esta desigualdade impactou os processos de ensino-aprendizagem. Tomou-se como norteadores desse estudo os conceitos de Cultura Digital e Condição Digital. Assim, partiu-se de uma revisão bibliográfica e documental sobre o uso e os acessos à Internet no Brasil, principalmente pela população escolar, para analisar esse panorama, dialogando com pesquisadores e estudiosos do campo da educação, da sociologia e da comunicação. Nesse percurso foi possível concluir que, tanto para os desiguais quanto para aqueles que se encontram em uma condição privilegiada de acesso à Cultura Digital, é preciso construir um novo contrato social que envolva uma agenda para elaboração de políticas públicas que garantam o acesso à Internet como um direito universal. Por outro lado, é importante fazer uso dos espaços digitais como apropriação de uma Cultura Digital que muda o mundo, o jeito de ser nele e seus valores. Nesse sentido, o digital não é apenas um ambiente, é um novo ecossistema que nos abriga.
Nelson e Carolina
Authors: De Castro Noronha da Silva Sheila , Lisbôa Costa de Oliveira Marcia 
Published: April 2024

O artigo apresenta resultados de uma pesquisa que objetivou desenvolver uma proposta antirracista de ensino de Língua Portuguesa na Educação de Jovens e Adultos (EJA), pautada em estudos contemporâneos sobre os letramentos. O quadro teórico da pesquisa interliga discussões sobre EJA (ARROYO, 2017) a análises sobre racismo e educação antirracista desenvolvidas por Djamila Ribeiro (2019), Chimamanda Ngozi Adichie (2019), bell hooks (2013) e Silvio Luiz de Almeida (2018), entrelaçando-as ao campo dos estudos sobre letramentos (STREET, 2014; KALANTZIS, COPE, PINHEIRO, 2020) e letramentos críticos (FREIRE, 1987; FREIRE e MACEDO, 2015; JANKS, 2000, 2014; CERVETTI, PARDALES e DAMICO 2001). A investigação qualitativa articulou pesquisa bibliográfica e propositiva, tendo como meta a produção de material didático para o ensino crítico de Língua Portuguesa na segunda etapa do ensino fundamental na modalidade EJA. Assim, foi elaborado um caderno pedagógico temático em torno de duas personalidades negras de grande relevância na resistência ao racismo e às injustiças sociais - Nelson Mandela e Carolina Maria de Jesus. A proposta do caderno pedagógico “Nelson e Carolina: vidas que inspiram” colocou em destaque a representatividade dessas personalidades negras, enfatizando reflexões sobre racismo, desigualdades e antirracismo, valorizando as vozes dos estudantes da EJA.
Skin in the game: a review of single-cell and spatial transcriptomics in dermatological research
Authors: Schepps Samuel , Xu Jonathan , Yang Henry , Mandel Jenna , Mehta Jaanvi , Tolotta Julianna , Baker Nicole , Tekmen Volkan , Nikbakht Neda , Fortina Paolo , Fuentes Ignacia , LaFleur Bonnie , Cho Raymond J. , South Andrew P. 
Published: April 2024

Abstract
Single-cell RNA sequencing (scRNA-seq) and spatial transcriptomics (ST) are two emerging research technologies that uniquely characterize gene expression microenvironments on a cellular or subcellular level. The skin, a clinically accessible tissue composed of diverse, essential cell populations, serves as an ideal target for these high-resolution investigative approaches. Using these tools, researchers are assembling a compendium of data and discoveries in healthy skin as well as a range of dermatologic pathophysiologies, including atopic dermatitis, psoriasis, and cutaneous malignancies. The ongoing advancement of single-cell approaches, coupled with anticipated decreases in cost with increased adoption, will reshape dermatologic research, profoundly influencing disease characterization, prognosis, and ultimately clinical practice.
Biosynthesis and screening of cobalt nanoparticles using citrus species for antimicrobial activity
Authors: Ali Huma , Dixit Savita , Alarifi Saud 
Published: April 2024

Abstract
The synthesis of the nanomaterial is crucial for its characteristics, as well as physiological features. Green nanoparticle production, which reduces metal ions using natural extracts rather than industrial chemical agents, has been created to lower costs, minimize pollution, and improve environmental and human health safety. An aqueous and methanolic extract of a combination of Citrus sinensis and Citrus limetta peel was utilized for the green synthesis of cobalt nanoparticles. UV–Visible, Fourier-transform Infrared, X-ray diffraction (XRD), scanning of electron microscopy (SEM) and other techniques were employed to describe the prepared cobalt nanoparticles. The crystal structure of cobalt nanoparticles was revealed by XRD study. The SEM images of the cobalt nanoparticles revealed the usual subdivision dimensions of 20–30 nm. Using the well diffusion method, the antibacterial activity of the crude extract derived from the combination of the two plants mentioned above and the biosynthesized cobalt nanoparticles was assessed. The result showed that the crude extract and cobalt nanoparticles exhibited antibacterial activity and cobalt nanoparticles exhibited much higher activity than the crude extract. Overall, these findings revealed that formulated cobalt nanoparticle treatment considerably prevented the development of different micro-organisms.
The existence of multiple solutions for a class of upper critical Choquard equation in a bounded domain
Authors: Chen Yongpeng , Yang Zhipeng 
Published: April 2024

Abstract
In this article, we consider the following Choquard equation with upper critical exponent:

−
Δ
u
=
μ
f

(

x

)

∣
u
∣

p
−
2

u
+
g

(

x

)

(

I

α

*

(

g

∣
u
∣

2

α

*

)

)

∣
u
∣

2

α

*

−
2

u
,

x
∈
Ω
,

-\Delta u=\mu f\left(x){| u| }^{p-2}u+g\left(x)({I}_{\alpha }* \left(g{| u| }^{{2}_{\alpha }^{* }})){| u| }^{{2}_{\alpha }^{* }-2}u,\hspace{1.0em}x\in \Omega ,

where

μ
>
0

\mu \gt 0

is a parameter,

N
>
4

N\gt 4

,

0
<
α
<
N

0\lt \alpha \lt N

,

I

α

{I}_{\alpha }

is the Riesz potential,

N

N
−
2

<
p
<
2

\frac{N}{N-2}\lt p\lt 2

,

Ω
⊂

R

N

\Omega \subset {{\mathbb{R}}}^{N}

is a bounded domain with smooth boundary, and

f

f

and

g

g

are continuous functions. For

μ

\mu

small enough, using variational methods, we establish the relationship between the number of solutions and the profile of potential

g

g

.
Random forests for survival data: which methods work best and under what conditions?
Authors: Berkowitz Matthew , Altman Rachel MacKay , Loughin Thomas M. 
Published: April 2024

Abstract
Few systematic comparisons of methods for constructing survival trees and forests exist in the literature. Importantly, when the goal is to predict a survival time or estimate a survival function, the optimal choice of method is unclear. We use an extensive simulation study to systematically investigate various factors that influence survival forest performance – forest construction method, censoring, sample size, distribution of the response, structure of the linear predictor, and presence of correlated or noisy covariates. In particular, we study 11 methods that have recently been proposed in the literature and identify 6 top performers. We find that all the factors that we investigate have significant impact on the methods’ relative accuracy of point predictions of survival times and survival function estimates. We use our results to make recommendations for which methods to use in a given context and offer explanations for the observed differences in relative performance.
A phenomenological account for causality in terms of elementary actions
Authors: Janzing Dominik , Mejia Sergio Hernan Garrido 
Published: April 2024

Abstract
Discussions on causal relations in real life often consider variables for which the definition of causality is unclear since the notion of interventions on the respective variables is obscure. Asking “what qualifies an action for being an intervention on the variable

X

X

” raises the question whether the action impacted all other variables only through X or directly, which implicitly refers to a causal model. To avoid this known circularity, we instead suggest a notion of “phenomenological causality” whose basic concept is a set of elementary actions. Then the causal structure is defined such that elementary actions change only the causal mechanism at one node (e.g. one of the causal conditionals in the Markov factorization). This way, the principle of independent mechanisms becomes the defining property of causal structure in domains where causality is a more abstract phenomenon rather than being an objective fact relying on hard-wired causal links between tangible objects. In other words, causal relations between variables get defined by the interface between the system and an external agent (who is able to perform the elementary actions), rather than being an internal property of links between the variables. We describe this phenomenological approach to causality for toy and hypothetical real-world examples and argue that it is consistent with the causal Markov condition when the system under consideration interacts with other variables that control the elementary actions.