bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mechanisms Underlying Age- and Performance-related Differences in Working Memory
Authors: Daffner Kirk R. , Chong Hyemi , Sun Xue , Tarbi Elise C. , Riis Jenna L. , McGinnis Scott M. , Holcomb Phillip J. 
Published: July 2010

AbstractThis study took advantage of the subsecond temporal resolution of ERPs to investigate mechanisms underlying age- and performance-related differences in working memory. Young and old subjects participated in a verbal n-back task with three levels of difficulty. Each group was divided into high and low performers based on accuracy under the 2-back condition. Both old subjects and low-performing young subjects exhibited impairments in preliminary mismatch/match detection operations (indexed by the anterior N2 component). This may have undermined the quality of information available for the subsequent decision-making process (indexed by the P3 component), necessitating the appropriation of more resources. Additional anterior and right hemisphere activity was recruited by old subjects. Neural efficiency and the capacity to allocate more resources to decision-making differed between high and low performers in both age groups. Under low demand conditions, high performers executed the task utilizing fewer resources than low performers (indexed by the P3 amplitude). As task requirements increased, high-performing young and old subjects were able to appropriate additional resources to decision-making, whereas their low-performing counterparts allocated fewer resources. Higher task demands increased utilization of processing capacity for operations other than decision-making (e.g., sustained attention) that depend upon a shared pool of limited resources. As demands increased, all groups allocated additional resources to the process of sustaining attention (indexed by the posterior slow wave). Demands appeared to have exceeded capacity in low performers, leading to a reduction of resources available to the decision-making process, which likely contributed to a decline in performance.
Assessing the Neural Basis of Uncertainty in Perceptual Category Learning through Varying Levels of Distortion
Authors: Daniel Reka , Wagner Gerd , Koch Kathrin , Reichenbach Jürgen R. , Sauer Heinrich , Schlösser Ralf G. M. 
Published: July 2010

AbstractThe formation of new perceptual categories involves learning to extract that information from a wide range of often noisy sensory inputs, which is critical for selecting between a limited number of responses. To identify brain regions involved in visual classification learning under noisy conditions, we developed a task on the basis of the classical dot pattern prototype distortion task [M. I. Posner, Journal of Experimental Psychology, 68, 113–118, 1964]. Twenty-seven healthy young adults were required to assign distorted patterns of dots into one of two categories, each defined by its prototype. Categorization uncertainty was modulated parametrically by means of Shannon's entropy formula and set to the levels of 3, 7, and 8.5 bits/dot within subsets of the stimuli. Feedback was presented after each trial, and two parallel versions of the task were developed to contrast practiced and unpracticed performance within a single session. Using event-related fMRI, areas showing increasing activation with categorization uncertainty and decreasing activation with training were identified. Both networks largely overlapped and included areas involved in visuospatial processing (inferior temporal and posterior parietal areas), areas involved in cognitive processes requiring a high amount of cognitive control (posterior medial wall), and a cortico-striatal–thalamic loop through the body of the caudate nucleus. Activity in the medial prefrontal wall was increased when subjects received negative as compared with positive feedback, providing further evidence for its important role in mediating the error signal. This study characterizes the cortico-striatal network underlying the classification of distorted visual patterns that is directly related to decision uncertainty.
The Evolution of Meaning: Spatio-temporal Dynamics of Visual Object Recognition
Authors: Clarke Alex , Taylor Kirsten I. , Tyler Lorraine K. 
Published: July 2010

Abstract
Research on the spatio-temporal dynamics of visual object recognition suggests a recurrent, interactive model whereby an initial feedforward sweep through the ventral stream to prefrontal cortex is followed by recurrent interactions. However, critical questions remain regarding the factors that mediate the degree of recurrent interactions necessary for meaningful object recognition. The novel prediction we test here is that recurrent interactivity is driven by increasing semantic integration demands as defined by the complexity of semantic information required by the task and driven by the stimuli. To test this prediction, we recorded magnetoencephalography data while participants named living and nonliving objects during two naming tasks. We found that the spatio-temporal dynamics of neural activity were modulated by the level of semantic integration required. Specifically, source reconstructed time courses and phase synchronization measures showed increased recurrent interactions as a function of semantic integration demands. These findings demonstrate that the cortical dynamics of object processing are modulated by the complexity of semantic information required from the visual input.
Potential Temperature and Potential Vorticity Inversion: Complementary Approaches
Authors: Egger Joseph , Hoinka Klaus-Peter 
Published: July 2010

Abstract
Given the distribution of one atmospheric variable, that of nearly all others can be derived in balanced flow. In particular, potential vorticity inversion (PVI) selects potential vorticity (PV) to derive pressure, winds, and potential temperature θ. Potential temperature inversion (PTI) starts from available θ fields to derive pressure, winds, and PV. While PVI has been applied extensively, PTI has hardly been used as a research tool although the related technical steps are well known and simpler than those needed in PVI. Two idealized examples of PTI and PVI are compared. The 40-yr European Centre for Medium-Range Weather Forecasts (ECMWF) Re-Analysis (ERA-40) datasets are used to determine typical anomalies of PV and θ in the North Atlantic storm-track region. Statistical forms of PVI and PTI are applied to these anomalies. The inversions are equivalent but the results of PTI are generally easier to understand than those of PVI. The issues of attribution and piecewise inversion are discussed.
Long-Range Dependence and Climate Noise Characteristics of Antarctic Temperature Data
Authors: Franzke Christian 
Published: July 2010

Abstract
This study examines the long-range dependency, climate noise characteristics, and nonlinear temperature trends of eight Antarctic stations from the Reference Antarctic Data for Environmental Research (READER) dataset. Evidence is shown that Antarctic temperatures are long-range dependent. To identify possible nonlinear trends, the ensemble empirical mode decomposition (EEMD) method is used, and then the question of whether the observed trends can arise from internal atmospheric fluctuations is examined. To answer this question, surrogate data are generated from two paradigmatic null models: a standard first-order autoregressive process representing a short-range dependent process and a fractional integrated process representing a long-range dependent process. It is found that three of the eight stations show statistically significant trends when tested against the short-range dependent process while only the Faraday–Vernadsky station temperature time series shows a significant trend when tested against the long-range dependent null model. All other considered stations show no trends that are statistically significant against the two null models, and thus they can be explained by internal atmospheric variability. These results imply that more attention should be given to assessing the correlation structure of climate time series.
A Consensus Model for Seasonal Hurricane Prediction
Authors: Jagger Thomas H. , Elsner James B. 
Published: July 2010

Abstract
The authors apply a procedure called Bayesian model averaging (BMA) for examining the utility of a set of covariates for predicting the distribution of U.S. hurricane counts and demonstrating a consensus model for seasonal prediction. Hurricane counts are derived from near-coastal tropical cyclones over the period 1866–2008. The covariate set consists of the May–October monthly averages of the Atlantic SST, North Atlantic Oscillation (NAO) index, Southern Oscillation index (SOI), and sunspot number (SSN). BMA produces posterior probabilities indicating the likelihood of the model given the set of annual hurricane counts and covariates. The September SSN covariate appears most often in the higher-probability models. The sign of the September SSN parameter is negative indicating that the probability of a U.S. hurricane decreases with more sunspots. A consensus hindcast for the 2007 and 2008 season is made by averaging forecasts from a large subset of models weighted by their corresponding posterior probability. A cross-validation exercise confirms that BMA can provide more accurate forecasts compared to methods that select a single “best” model. More importantly, the BMA procedure incorporates more of the uncertainty associated with making a prediction of this year’s hurricane activity from data.
Hepatic Drug-Metabolizing Enzyme Induction and Implications for Preclinical and Clinical Risk Assessment
Authors: Mohutsky Michael A. , Romeike Annette , Meador Vince , Lee William M. , Fowler John , Francke-Carroll Sabine 
Published: July 2010

Hepatic drug metabolizing enzyme (DME) induction complicates the development of new drugs owing to altered efficacy of concomitant treatments, reduction in exposure resulting from autoinduction, and potential generation of toxic metabolites. Risk assessment of DME induction during clinical evaluation is confounded by several uncertainties pertaining to hazard identification and dose response analysis. Hepatic DME induction rarely leads to clinical evidence of altered metabolism and toxicity in the patient, which typically occur only if the DME induction is relatively severe. High drug doses are associated with a greater likelihood of hepatic DME induction and downstream effects; therefore, drugs of low potency requiring higher dosing tend to lead to a greater risk of drug–drug interactions. Vigilance in clinical trials for increased or diminished drug effect and, specifically, pharmacokinetic studies in the presence of other drugs and concomitant diseases are necessary for a drug risk assessment profile.Efforts to remove hepatic DME-inducing drugs from development can be facilitated with current in vitro and in vivo assessments and will improve with the development of newer technologies. A carefully tailored case-by-case approach will lead to the development of efficacious drugs with an acceptable risk/benefit profile available to patients.
Sports Activity after Anatomical Total Shoulder Arthroplasty
Authors: Schumann Katrin , Flury Matthias P. , Schwyzer Hans-Kaspar , Simmen Beat R. , Drerup Susann , Goldhahn Joerg 
Published: July 2010

Background Implant functionality has clearly increased over the past decades because of improvements in total shoulder arthroplasty systems. This means that prostheses are now being implanted in younger patients with high sports activity. Hypothesis The implantation of the total shoulder arthroplasty does not mainly influence the sports activity. Study Design Case series; Level of evidence, 4. Methods One hundred consecutive patients with unilateral total shoulder arthroplasty, followed for at least 1 year, were included in the study. Assessment preoperatively and 1 year and 2 years after operation included clinical examination and a validated questionnaire (Constant, Shoulder Pain and Disability Index [SPADI], and Disabilities of the Arm, Shoulder and Hand [DASH] scores, and the Short Form 36 [SF-36]). In addition, all patients received a sports questionnaire developed in house. Results Of the 55 patients who took part in sports before having shoulder disease, 49 (89%) were still able to participate after a mean follow-up of 2.8 years (range, 1.3-4.6 years). Seventeen patients had given up sports before total shoulder arthroplasty; 11 of them resumed activities after joint replacement but 6 did not start again. No patient had to stop sports because of the total shoulder arthroplasty. The sports most commonly mentioned were swimming (10 patients [20.4%]), golf (8 patients [16.3%]), cycling (8 patients [16.3%]), and fitness training (8 patients [16.3%]). Strength and range of motion, as well as the physical component summary (PCS) of the SF-36 and the Constant score (CS) after total shoulder arthroplasty, were significantly better in the sports group (49 of 100; PCS = 46, CS = 77) than in the nonsports group (45 of 100; PCS = 41,CS = 71). Eighteen patients (36.7%) stated that even after joint replacement, they still suffered restrictions on their sports activities because of shoulder problems. Whereas the overall mean age at follow-up was 68.9 years (range, 26-92 years), the mean age of patients participating in sports was significantly lower than in the nonsports group (63 vs 70 years; P = .002). Conclusion Total shoulder arthroplasty allows patients to participate in sports without significant restriction of their level of activity. The probability of being able to do sports postoperatively—if done preoperatively—is high. Long-term studies are needed to determine whether the greater loading on the joint will lead to more rapid wear and a higher rate of loosening with time.
Incidence of Acute Traumatic Patellar Dislocation among Active-Duty United States Military Service Members
Authors: Hsiao Mark , Owens Brett D. , Burks Robert , Sturdivant Rodney X. , Cameron Kenneth L. 
Published: July 2010

Background Although some studies have reported an increased incidence of patellar dislocations within active populations, few studies have reported incidence rates and examined risk factors for this injury. Purpose To examine the incidence of patellar dislocation injuries and the influence of demographic and occupational risk factors associated with injury among active-duty United States (US) service members between 1998 and 2007. Study Design Cohort study; Level of evidence, 3. Methods Using the Defense Medical Surveillance System, a search was performed for International Classification of Disease, 9th Revision (ICD-9) code 836.3 among all US service members on active duty during the study period. Multivariable Poisson regression analysis was used to estimate the rate of patellar dislocation per 1000 person-years at risk to injury. Incidence rates (IRs) and incidence rate ratios (IRRs) for patellar dislocation along with 95% confidence intervals (CIs) were estimated by gender, age, race, branch of military service, and rank while controlling for the other variables in the model. Results There were a total of 9299 individuals with documented patellar dislocation injuries among a population at risk of 13 443 448 person-years. The IR was 0.69 per 1000 person-years at risk. Women were 61% more likely (IRR, 1.61; 95% CI, 1.53-1.69) to sustain a patellar dislocation injury than men. Rates were highest in the youngest age group and decreased with increasing age. Service members aged <20 years were 84% more likely (IRR, 1.84; 95% CI, 1.61-2.10) to sustain a patellar dislocation injury as service members aged ≥40 years. Differences were also noted by race, service, and rank. Conclusion The incidence of patellar dislocation injuries among US service members was an order of magnitude greater than that previously reported in civilian population studies. Gender, age, race, rank, and branch of military service are important risk factors related to the incidence of patellar dislocation injuries in this population.
Alterations in serum MMP-8, MMP-9, IL-12p40 and IL-23 in multiple sclerosis patients treated with interferon-β1b
Authors: Alexander JS , Harris MK , Wells SR , Mills G. , Chalamidas K. , Ganta VC , McGee J. , Jennings MH , Gonzalez-Toledo E. , Minagar A. 
Published: July 2010

Background: Interferon-β1b (IFN-β1b), an effective treatment for multiple sclerosis (MS), lessens disease severity in MS patients. However, the mechanisms of its immunoregulatory and anti-inflammatory effects in MS remain only partially understood. Matrix metalloproteinases (MMP) and tissue inhibitor of matrix metalloproteinase-1 (TIMP-1) are involved in blood brain barrier disruption and formation of MS lesions. Th1/Th17 cytokines e.g. interleukins IL-12p40, IL-17, and IL-23, are associated with MS disease activity and are significant players in pathogenesis of MS. Objective: During a 1-year prospective study, we serially measured serum MMP-8, MMP-9, TIMP-1, IL-12p40, IL-17, and IL-23 in 24 patients with relapsing—remitting MS. We compared the results to clinical course and to brain magnetic resonance imaging. IFN-β1b decreased serum MMP-8 and MMP-9 (not TIMP-1). Results: The sustained treatment with IFN-β1b attenuated the pro-inflammatory environment by significantly reducing the serum IL-12p40, IL-23, and showed a trend for decreasing IL-17. Decreased serum MMP-8, MMP-9, IL-12 and IL-23 levels were correlated with a decrease in the number of contrast-enhanced T2-weighted lesions. Conclusion: Early treatment of MS with IFN-β1b may stabilize clinical disease by attenuating levels of inflammatory cytokines and MMPs. Serial measurement of inflammatory mediators may serve as sensitive markers to gauge therapeutic responses to IFN-β1b during the first year of treatment.
Fc-engineered anti-CD40 antibody enhances multiple effector functions and exhibits potent in vitro and in vivo antitumor activity against hematologic malignancies
Authors: Horton Holly M. , Bernett Matthew J. , Peipp Matthias , Pong Erik , Karki Sher , Chu Seung Y. , Richards John O. , Chen Hsing , Repp Roland , Desjarlais John R. , Zhukovsky Eugene A. 
Published: July 2010

AbstractCD40 is highly expressed on various B-lineage malignancies and represents an attractive immunotherapy target for neoplastic disease. Previous work showed that engineering the Fc domain of an antibody for increased binding to Fcγ receptors (FcγRs) significantly enhanced Fc-mediated immune effector function and antitumor activity in vitro and in vivo. We developed a humanized anti-CD40 antibody similarly Fc-engineered for increased FcγR binding (XmAbCD40) and compared its efficacy with that of an anti-CD40 native IgG1 analog and the anti-CD20 antibody rituximab. XmAbCD40 increased antibody-dependent cell-mediated cytotoxicity (ADCC) up to 150-fold relative to anti-CD40 IgG1 against B-lymphoma, leukemia, and multiple myeloma cell lines, and significantly enhanced ADCC against primary tumors. XmAbCD40 was also superior to rituximab in enhancing ADCC (both in cell lines and primary tumors) and in augmenting antibody-dependent cellular phagocytosis. XmAbCD40 significantly inhibited lymphoma growth in disseminated and established mouse xenografts and was more effective than the IgG1 analog or rituximab. An anti-CD40 antibody constructed to abrogate FcγR binding showed no reduction of tumor growth, indicating that the in vivo antitumor activity of XmAbCD40 is primarily mediated via FcγR-dependent mechanisms. These data demonstrate that XmAbCD40 displays potent antitumor efficacy and merits further evaluation for the treatment of CD40+ malignancies.
Severe congenital neutropenia resulting from G6PC3 deficiency with increased neutrophil CXCR4 expression and myelokathexis
Authors: McDermott David H. , De Ravin Suk See , Jun Hyun Sik , Liu Qian , Priel Debra A. Long , Noel Pierre , Takemoto Clifford M. , Ojode Teresa , Paul Scott M. , Dunsmore Kimberly P. , Hilligoss Dianne , Marquesen Martha , Ulrick Jean , Kuhns Douglas B. , Chou Janice Y. , Malech Harry L. , Murphy Philip M. 
Published: July 2010

AbstractMutations in more than 15 genes are now known to cause severe congenital neutropenia (SCN); however, the pathologic mechanisms of most genetic defects are not fully defined. Deficiency of G6PC3, a glucose-6-phosphatase, causes a rare multisystem syndrome with SCN first described in 2009. We identified a family with 2 children with homozygous G6PC3 G260R mutations, a loss of enzymatic function, and typical syndrome features with the exception that their bone marrow biopsy pathology revealed abundant neutrophils consistent with myelokathexis. This pathologic finding is a hallmark of another type of SCN, WHIM syndrome, which is caused by gain-of-function mutations in CXCR4, a chemokine receptor and known neutrophil bone marrow retention factor. We found markedly increased CXCR4 expression on neutrophils from both our G6PC3-deficient patients and G6pc3−/− mice. In both patients, granulocyte colony-stimulating factor treatment normalized CXCR4 expression and neutrophil counts. In G6pc3−/− mice, the specific CXCR4 antagonist AMD3100 rapidly reversed neutropenia. Thus, myelokathexis associated with abnormally high neutrophil CXCR4 expression may contribute to neutropenia in G6PC3 deficiency and responds well to granulocyte colony-stimulating factor.
Role of Krüppel-like factors in leukocyte development, function, and disease
Authors: Cao Zhuoxiao , Sun Xinghui , Icli Basak , Wara Akm Khyrul , Feinberg Mark W. 
Published: July 2010

AbstractThe Krüppel-like transcription factor (KLF) family participates in diverse aspects of cellular growth, development, differentiation, and activation. Recently, several groups have identified new connections between the function of these factors and leukocyte responses in health and disease. Gene targeting of individual KLFs in mice has uncovered novel and unexpected physiologic roles among myeloid and lymphocyte cell lineage maturation, particularly in the bone marrow niche and blood. In addition, several KLF family members are downstream targets of stimuli and signaling pathways critical to T-cell trafficking, T regulatory cell differentiation or suppressor function, monocyte/macrophage activation or renewal, and B memory cell maturation or activation. Indeed, KLFs have been implicated in subtypes of leukemia, lymphoma, autoimmunity, and in acute and chronic inflammatory disease states, such as atherosclerosis, diabetes, and airway inflammation, raising the possibility that KLFs and their upstream signals are of therapeutic interest. This review focuses on the relevant literature of Krüppel-like factors in leukocyte biology and their implications in clinical settings.