bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pulmonary transplant complications: a radiologic review
Authors: Friedlander Samuel , Pogatchnik Brian , Furuya Yuka , Allen Tadashi 
Published: May 2024

AbstractLung transplantation has become the definitive treatment for end stage respiratory disease. Numbers and survival rates have increased over the past decade, with transplant recipients living longer and with greater comorbidities, resulting in greater complexity of care. Common and uncommon complications that occur in the immediate, early, intermediate, and late periods can have significant impact on the course of the transplant. Fortunately, advancements in surgery, medical care, and imaging as well as other diagnostics work to prevent, identify, and manage complications that would otherwise have a negative impact on survivability. This review will focus on contextualizing complications both categorically and chronologically, with highlights of specific imaging and clinical features in order to inform both radiologists and clinicians involved in post-transplant care.
Study on risk factors and treatment strategies of hypoxemia after acute type a aortic dissection surgery
Authors: Yu Wenbo , Liang Yuan , Gao Jianfeng , Xiong Jianxian 
Published: May 2024

AbstractAcute type A aortic dissection is a life-threatening cardiovascular disease characterized by rapid onset and high mortality. Emergency surgery is the preferred and reliable treatment option. However, postoperative complications significantly impact patient prognosis. Hypoxemia, a common complication, poses challenges in clinical treatment, negatively affecting patient outcomes and increasing the risk of mortality. Therefore, it is crucial to study and comprehend the risk factors and treatment strategies for hypoxemia following acute type A aortic dissection to facilitate early intervention.
Risk factors and prognostic significance of early postoperative complications for patients who underwent pneumonectomy for lung cancer
Authors: Batıhan Güntuğ , Ceylan Kenan Can , Kaya Şeyda Örs 
Published: May 2024

Abstract
Background
Although pneumonectomy has relatively high mortality and morbidity rates, it remains valid in the surgical treatment of lung cancer. This study aims to evaluate the prognostic significance of postoperative complications after pneumonectomy and demonstrate the risk factors related to early postoperative complications.

Methods
Patients who underwent pneumonectomy for non-small cell lung cancer between January 2008 and May 2021 were included in the study. Factors related to the development of early postoperative complications and overall survival were evaluated by univariate and multivariate analyses.

Results
A total of 136 patients were included in the study. Early postoperative complications were seen in 33 (24.3%) patients and late postoperative complications in 7 (5.1%) patients. The amount of cigarette smoking, and the operation side were the independent variables that affect the development of early postoperative complications. In multivariate analysis, smoking amount and pericardial invasion were associated with the development of postoperative hemorrhage, and advanced age was associated with the development of postoperative pneumonia.

Conclusions
Early postoperative complications have a negative effect on the prognosis after pneumonectomy therefore careful patient selection and preoperative risk assessment are essential to minimize the occurrence of complications and improve patient outcomes.

Trial registration
This observational study was approved by the (Ethical Committee of Dr. Suat Seren Chest Diseases and Chest Surgery Education and Research Center) Institutional Review Board of our center (E-49109414-604.02.02-218625439).
Chronic pain enhances excitability of corticotropin-releasing factor-expressing neurons in the oval part of the bed nucleus of the stria terminalis
Authors: Uchida Ryoko , Mukai Yasutaka , Amano Taiju , Sakimura Kenji , Itoi Keiichi , Yamanaka Akihiro , Minami Masabumi 
Published: May 2024

AbstractWe previously reported that enhanced corticotropin-releasing factor (CRF) signaling in the bed nucleus of the stria terminalis (BNST) caused the aversive responses during acute pain and suppressed the brain reward system during chronic pain. However, it remains to be examined whether chronic pain alters the excitability of CRF neurons in the BNST. In this study we investigated the chronic pain-induced changes in excitability of CRF-expressing neurons in the oval part of the BNST (ovBNSTCRF neurons) by whole-cell patch-clamp electrophysiology. CRF-Cre; Ai14 mice were used to visualize CRF neurons by tdTomato. Electrophysiological recordings from brain slices prepared from a mouse model of neuropathic pain revealed that rheobase and firing threshold were significantly decreased in the chronic pain group compared with the sham-operated control group. Firing rate of the chronic pain group was higher than that of the control group. These data indicate that chronic pain elevated neuronal excitability of ovBNSTCRF neurons.
CXCR6-positive circulating mucosal-associated invariant T cells can identify patients with non-small cell lung cancer responding to anti-PD-1 immunotherapy
Authors: Qu Jingjing , Wu Binggen , Chen Lijun , Wen Zuoshi , Fang Liangjie , Zheng Jing , Shen Qian , Heng Jianfu , Zhou Jianya , Zhou Jianying 
Published: May 2024

Abstract
Background
Mucosal-associated invariant T (MAIT) cells have been reported to regulate tumor immunity. However, the immune characteristics of MAIT cells in non-small cell lung cancer (NSCLC) and their correlation with the treatment efficacy of immune checkpoint inhibitors (ICIs) remain unclear.

Patients and methods
In this study, we performed single-cell RNA sequencing (scRNA-seq), flow cytometry, and multiplex immunofluorescence assays to determine the proportion and characteristics of CD8+MAIT cells in patients with metastatic NSCLC who did and did not respond to anti-PD-1 therapy. Survival analyses were employed to determine the effects of MAIT proportion and C-X-C chemokine receptor 6 (CXCR6) expression on the prognosis of patients with advanced NSCLC.

Results
The proportion of activated and proliferating CD8+MAIT cells were significantly higher in responders-derived peripheral blood mononuclear cells (PBMCs) and lung tissues before anti-PD-1 therapy, with enhanced expression of cytotoxicity-related genes including CCL4, KLRG1, PRF1, NCR3, NKG7, GZMB, and KLRK1. The responders’ peripheral and tumor-infiltrating CD8+MAIT cells showed an upregulated CXCR6 expression. Similarly, CXCR6+CD8+MAIT cells from responders showed higher expression of cytotoxicity-related genes, such as CST7, GNLY, KLRG1, NKG7, and PRF1. Patients with ≥15.1% CD8+MAIT cells to CD8+T cells ratio and ≥35.9% CXCR6+CD8+MAIT cells to CD8+MAIT cells ratio in peripheral blood showed better progression-free survival (PFS) after immunotherapy. The role of CD8+MAIT cells in lung cancer immunotherapy was potentially mediated by classical/non-classical monocytes through the CXCL16-CXCR6 axis.

Conclusion
CD8+MAIT cells are a potential predictive biomarker for patients with NSCLC responding to anti-PD-1 therapy. The correlation between CD8+MAIT cells and immunotherapy sensitivity may be ascribed to high CXCR6 expression.
Simultaneous measurement of duloxetine hydrochloride and avanafil at dual-wavelength using novel ecologically friendly TLC-densitometric method: application to synthetic mixture and spiked human plasma with evaluation of greenness and blueness
Authors: Derayea Sayed M. , Elhamdy Hadeer A. , Oraby Mohamed , El-Din Khalid M. Badr 
Published: May 2024

AbstractThe simultaneous assay of duloxetine hydrochloride (DLX) and avanafil (AVN) in their pure forms, synthetic mixtures, and spiked human plasma was achieved using a novel, eco-friendly, sensitive, and specific HPTLC methodology that have been established and validated. Measuring the levels of co-administered antidepressants and sexual stimulants in biological fluids is an important step for individuals with depression and sexual problems. Separation was performed successfully using pre-coated silica gel 60-F254 as a stationary phase and a mobile phase composed of methanol, acetone, and 33% ammonia (8:2:0.05, v/v/v). Compact bands were produced by the optimized mobile phase that was chosen for development (Rf values were 0.23 and 0.75 for DLX and AVN, individually) after dual-wavelength detection for DLX and AVN at 232 and 253 nm, respectively. The results of polynomial regression analysis were exceptional (r = 0.9999 for both medicines) over concentration ranges of 5-800 and 10-800ng/spot for DLX and AVN, respectively. The quantitation limits were 4.69 and 9.53 ng/spot (0.31 and 0.94 µg/mL), whereas the detection limits were 1.55 and 3.15 ng/spot (0.63 and 1.91 µg/mL), for DLX and AVN, respectively. The International Council for Harmonization (ICH) criteria served as the basis for validating the established approach. Moreover, the proposed technique was evaluated in terms of greenness using four contemporary ecological metrics: The Analytical Greenness software (AGREE), the Green Analytical Procedure Index (GAPI), Eco-Scale, and the National Environmental Method Index (NEMI). Additionally, the Blue Applicability Grade Index (BAGI), a newly developed tool for evaluating the practicality (blueness) of procedures, was taken into consideration when evaluating the sustainability levels of the established approach.
Dissecting zero trust: research landscape and its implementation in IoT
Authors: Liu Chunwen , Tan Ru , Wu Yang , Feng Yun , Jin Ze , Zhang Fangjiao , Liu Yuling , Liu Qixu 
Published: May 2024

AbstractAs a progressive security strategy, the zero trust model has attracted notable attention and importance within the realm of network security, especially in the context of the Internet of Things (IoT). This paper aims to evaluate the current research regarding zero trust and to highlight its practical applications in the IoT sphere through extensive bibliometric analysis. We also delve into the vulnerabilities of IoT and explore the potential role of zero trust security in mitigating these risks via a thorough review of relevant security schemes. Nevertheless, the challenges associated with implementing zero trust security are acknowledged. We provide a summary of these issues and suggest possible pathways for future research aimed at overcoming these challenges. Ultimately, this study aims to serve as a strategic analysis of the zero trust model, intending to empower scholars in the field to pursue deeper and more focused research in the future.
Minimal Residual Disease Status in Multiple Myeloma 1 Year After Autologous Hematopoietic Cell Transplantation and Lenalidomide Maintenance Are Associated With Long-Term Overall Survival
Authors: Pasquini Marcelo C. , Wallace Paul K. , Logan Brent , Kaur Manmeet , Tario Joseph D. , Howard Alan , Zhang Yali , Brunstein Claudio , Efebera Yvonne , Geller Nancy , Giralt Sergio , Hari Parameswaran , Horowitz Mary M. , Koreth John , Krishnan Amrita , Landau Heather , Somlo George , Shah Nina , Stadtmauer Edward , Vogl Dan T. , Vesole David H. , McCarthy Philip L. , Hahn Theresa 
Published: May 2024

PURPOSE Prognostic Immunophenotyping in Myeloma Response (PRIMeR) is an ancillary study of minimal residual disease (MRD) assessment for multiple myeloma by next-generation multiparameter flow cytometry (MFC). Patients were enrolled on a three-arm randomized control trial (Blood and Marrow Transplants Clinical Trials Network 0702 Stem Cell Transplant for Myeloma in Combination of Novel Agents [STaMINA]; ClinicalTrials.gov identifier: NCT01109004 ). METHODS Four hundred and thirty-five patients consented to the MRD panel, which included 10 monoclonal antibodies measured via six-color MFC. MRD was measured at baseline/preautologous hematopoietic cell transplant (BL/preAutoHCT), premaintenance (PM), and 1 year (Y1) after AutoHCT with a sensitivity of 10–5 to 10–6. The primary objective was to assess MRD-negative (MRDneg) at 1 year after AutoHCT and progression-free survival and overall survival (PFS/OS). RESULTS Similar to the STaMINA results, at a median follow-up of 70 months, there was no significant difference in PFS/OS by treatment arm in the PRIMeR patients. MRDneg at all three time points was associated with significantly improved PFS, and MRDneg at Y1 had significantly longer OS. Multivariate analysis of PFS, adjusting for disease risk and treatment arm, demonstrated hazard ratios (HRs) in MRD-positive patients compared with MRDneg patients at BL, PM, and Y1 of 1.55 ( P = .0074), 1.83 ( P = .0007), and 3.61 ( P < .0001), respectively. Corresponding HRs for OS were 1.19 ( P = .48), 0.88 ( P = .68), and 3.36 ( P < .001). Patients with sustained MRDneg or who converted to MRDneg by Y1 had similar PFS/OS. CONCLUSION To our knowledge, this first, prospective US cooperative group, multicenter study demonstrates that MRDneg at Y1 after AutoHCT with lenalidomide maintenance is prognostic for improved 6-year PFS and OS. Serial MRD measurements may direct trials to test how further therapy may improve long-term PFS and OS.
Pseudomagnetic fields in bilayer phononic crystals
Authors: Fu Zhenlin , Zheng Riyi , Liang Jialuo , Lu Jiuyang , Deng Weiyin , Ke Manzhu , Huang Xueqin , Liu Zhengyou 
Published: May 2024

Abstract
Pseudomagnetic field (PMF), as an artificial gauge field, has attracted widespread attention in the exploration of magnetic-like effects in artificial structural materials. It offers a novel mechanism for manipulating wave fields in classical wave systems where there is no or weak response to actual magnetic fields. In this work, we construct acoustic PMFs in bilayer phononic crystals by imposing uniaxial linear gradient strain on the scatterers of both layers. Under the PMFs, the linear nodal rings, occurring at around the K and

points of the bilayer phononic crystals, split into acoustics Landau levels (LLs). Specifically, the n = 0 plateau of the LLs splits into two discrete ones due to the interlayer coupling. Furthermore, we construct two heterostructures by splicing two phononic crystals with opposite PMFs and observe unique in-plane snake-like propagations of the edge state as well as oscillations between the upper and lower layers. Bilayer structure provides additional degree of freedom to generate PMFs in various types of semimetals and enriches the manipulation of acoustic wave propagations. In addition, it can be extended to other classical wave systems, such as electromagnetic wave and mechanical systems.
Metabolic Syndrome and the Risk of Kidney Stones: Evidence from 487 860 UK Biobank Participants
Authors: Liu Minghui , Gao Meng , Wu Jian , Zhu Zewu , Hu Jiao , Chen Hequn , Chen Zhiyong , Chen Jinbo 
Published: May 2024

Abstract

Context
While some studies have suggested an association between metabolic syndrome and kidney stones, the quality and level of evidence in these studies vary.

Objective
Whether some individual characteristics and clustering of metabolic syndrome traits increase the risk of kidney stones has not been examined in a large-scale prospective cohort.

Materials
We conducted a retrospective analysis of data from a prospective cohort of 487 860 UK Biobank participants who were free from kidney stones at baseline. The presence of metabolic syndrome was based on 5 criteria: abdominal obesity, high triglyceride levels, low high-density lipoprotein (HDL) cholesterol levels, high blood pressure (HBP), and type 2 diabetes mellitus (T2DM). Cox proportional hazards regression models were used to evaluate the association between metabolic syndrome and risk of kidney stones.

Results
After an average follow-up period of 12.6 years, a total of 5213 of the 487 860 participants included in the UK Biobank study developed kidney stones. The partial traits of metabolic syndrome, including waist circumference (hazard ratio [HR]: 1.15; 95% CI, 1.10-1.20), HDL cholesterol (0.66; 95% CI, 0.55-0.79), HBP (1.11; 95% CI, 1.03-1.19), and T2DM (1.14; 95% CI, 1.04-1.21), were independently associated with the occurrence of kidney stones. The clustering of metabolic syndrome is significantly associated with kidney stone formation, and as the number of metabolic syndrome traits increases, the risk of kidney stones gradually increases.

Conclusion
Metabolic syndrome is a significant and independent risk factor for the development of kidney stones. This association suggests that kidney stones may represent a systemic disorder influenced by the interplay of various metabolic risk factors.
The Influence of Trinucleotide Repeats in the Androgen Receptor Gene on Androgen-related Traits and Diseases
Authors: Sasako Takayoshi , Ilboudo Yann , Liang Kevin Y H , Chen Yiheng , Yoshiji Satoshi , Richards J Brent 
Published: May 2024

Abstract

Context
Trinucleotide repeats in the androgen receptor have been proposed to influence testosterone signaling in men, but the clinical relevance of these trinucleotide repeats remains controversial.

Objective
To examine how androgen receptor trinucleotide repeat lengths affect androgen-related traits and disease risks and whether they influence the clinical importance of circulating testosterone levels.

Methods
We quantified CAG and GGC repeat lengths in the androgen receptor (AR) gene of European-ancestry male participants in the UK Biobank from whole-genome and whole-exome sequence data using ExpansionHunter and tested associations with androgen-related traits and diseases. We also examined whether the associations between testosterone levels and these outcomes were affected by adjustment for the repeat lengths.

Results
We successfully quantified the repeat lengths from whole-genome and/or whole-exome sequence data in 181 217 males. Both repeat lengths were shown to be positively associated with circulating total testosterone level and bone mineral density, whereas CAG repeat length was negatively associated with male-pattern baldness, but their effects were relatively small and were not associated with most of the other outcomes. Circulating total testosterone level was associated with various outcomes, but this relationship was not affected by adjustment for the repeat lengths.

Conclusion
In this large-scale study, we found that longer CAG and GGC repeats in the AR gene influence androgen resistance, elevate circulating testosterone level via a feedback loop, and play a role in some androgen-targeted tissues. Generally, however, circulating testosterone level is a more important determinant of androgen action in males than repeat lengths.
Thyroid Dysfunction Risk After Iodinated Contrast Media Administration: A Prospective Longitudinal Cohort Analysis
Authors: Sohn Seo Young , Inoue Kosuke , Bashir Muhammad T , Currier Jesse W , Neverova Natalia V , Ebrahimi Ramin , Rhee Connie M , Lee Martin L , Leung Angela M 
Published: May 2024

Abstract

Context
Iodinated contrast media (ICM) is a common source of excess iodine in medical settings, given the common use of iodinated radiologic procedures.

Objective
To determine the long-term risks of thyroid dysfunction following iodinated contrast administration in a prospective study.

Methods
A longitudinal cohort study was conducted of patients in the United States Veterans Affairs medical system who received ICM. Serum thyroid function, thyroid antibody, and inflammatory markers were measured at baseline. Thyroid function tests were repeated at 1 month, 3 months, and every 6 months thereafter until 36 months. Risk of thyroid dysfunction and longitudinal changes in thyroid hormone levels were assessed using mixed effect models.

Results
There were 122 participants (median age, 70.0 [interquartile range 62.2-74.0] years; 98.4% male). At baseline, 6 subjects had subclinical thyroid dysfunction prior to ICM receipt. During median follow-up of 18 months, iodine-induced thyroid dysfunction was observed in 11.5% (14/122); 6 (4.9%) developed hyperthyroidism (including 1 with overt hyperthyroidism) and 8 (6.6%) subclinical hypothyroidism. At last follow-up, 10 of 20 subjects with thyroid dysfunction (14 new-onset cases and 6 with preexisting thyroid dysfunction) had persistent subclinical hyperthyroidism or hypothyroidism. There were also subtle changes in thyroid hormones observed longitudinally within the reference ranges in the overall cohort.

Conclusion
There is a rare long-term risk of an excess iodine load on thyroid dysfunction even among individuals from an overall iodine-sufficient region, supporting the need for targeted monitoring following iodinated contrast administration.
Feminism against Cisness
Authors: Heaney Emma 
Published: May 2024

The contributors to Feminism against Cisness showcase the future of feminist historical, theoretical, and political thought freed from the conceptual strictures of cisness: the fallacy that assigned sex determines sexed experience. The essays demonstrate that this fallacy hinges on the enforcement of white and bourgeois standards of gender comportment that naturalize brutalizing race and class hierarchies. It is, therefore, no accident that the social processes making cisness compulsory are also implicated in anti-Blackness, misogyny, Indigenous erasure, xenophobia, and bourgeois antipathy for working-class life. Working from trans historical archives and materialist trans feminist theories, this volume demonstrates the violent work that cis ideology has done and thinks toward a future for feminism beyond this ideology's counterrevolutionary pull.
Contributors. Cameron Awkward-Rich, Marquis Bey, Kay Gabriel, Jules Gill-Peterson, Emma Heaney, Margaux L. Kristjansson, Greta LaFleur, Grace Lavery, Durba Mitra, Beans Velocci, Joanna Wuest
Cost Structure and the Usefulness of Earnings
Authors: Cadman Brian , Ferracuti Elia 
Published: May 2024

We investigate the relation between the usefulness of earnings and firm cost structure. We document that the usefulness of earnings to external users decreases in the degree of operating leverage, which measures the proportion of fixed to variable costs, and that this decline extends at least partially from the relation between the degree of operating leverage and two earnings properties: aggressive revenue recognition to meet an earnings target and earnings volatility. Our results illustrate how firm fundamentals influence a firm’s information environment and thereby the usefulness of earnings to external users. This paper was accepted by Ranjani Krishnan, accounting. Supplemental Material: The data files are available at https://doi.org/10.1287/mnsc.2021.03023 .
Initial evaluation of a technologyenabled change in delivery of the dementia service during COVID-19 in North Warwickshire
Authors: Singh Sid , Moore Ellie , Melissa Paolo , Patel Vinod , Brown James , Davidson Jan 
Published: May 2024

Background: Remote monitoring technologies show potential to help health professionals deliver preventative interventions which can avoid hospital admissions and allow patients to remain in a home setting. Aims: To assess whether an Internet of Things (IoT) driven remote monitoring technology, used in the care pathway of community dementia patients in North Warwickshire improved access to care for patients and cost effectiveness. Method: Patient level changes to anonymised retrospective healthcare utilisation data were analysed alongside costs. Results: Urgent care decreased following use of an IoT driven remote monitoring technology; one preventative intervention avoided an average of three urgent interventions. A Chi-Square test showing this change as significant. Estimates show annualised service activity avoidance of £201,583 for the cohort; £8764 per patient. Conclusions: IoT driven remote monitoring had a positive impact on health utilisation and cost avoidance. Future expansion of the cohort will allow for validation of the results and consider the impact of the technology on patient health outcomes and staff workflows.