bluuebunny/crossref_metadata_2025_split huggingface dataset:
Natural abundance 17O NMR spectroscopy of heterocyclic N‐oxides and Di N‐oxides. Structural effects
Authors: Boykin D. W. , Balakrishnan P. , Baumstark A. L. 
Published: April 2009

AbstractThe 17O chemical shift data for a series of azine N‐oxides, diazine N‐oxides and di‐N‐oxides at natural abundance are reported. Isomeric methyl substituted quinoline N‐oxides exhibited chemical shifts which are interpreted in terms of electronic and compressional effects. The 17O chemical shift for 8‐methylquinoline N‐oxide (370 ppm) is deshielded by 25 ppm more than predicted, based upon electronic considerations. The 17O chemical shift for the N‐oxide of 8‐hydroxyquinoline (289 ppm) is substantially shielded as a result of intramolecular hydrogen bonding. The relative 17O chemical shifts for diazine N‐oxides of pyrazine, pyridazine and pyrimidine follow predictions based on back donation considerations. Because of solubility limitations, spectra of only two N,N′‐dioxides were obtained. The chemical shift of benzopyrazine di N‐oxide in acetonitrile was shielded by 18 ppm compared to that of its mono N‐oxide.
Reactivity of some 3‐substituted derivatives of 2,6‐dihalogenopyridines towards potassium amide in liquid ammonia [a]
Authors: Streef J. W. , Den Hertog H. J. , Van Der Plas H. C. 
Published: April 2009

AbstractReactions of 2,6‐dichloro‐3‐phenyl‐, 2,6‐dibromo‐3‐phenyl‐, 2,6‐dichloro‐3‐dimethylamino‐ and 2,6‐dibromo‐3‐dimethylaminopyridine with potassium amide in liquid ammonia were investigated. Whereas 2,6‐dichloro‐3‐phenylpyridine yields 4‐amino‐2‐benzylpyrimidine, from 2,6‐dibromo‐3‐phenylpyridine as a product of a novel ring fission 2‐amino‐l‐cyano‐l‐phenyl‐but‐l‐en‐3‐yne was isolated, together with 4‐amino‐6‐bromo‐3‐phenylpyridine and 2,6‐diamino‐3‐phenylpyridine. It was shown that neither 2‐amino‐6‐bromo‐3‐phenyl‐ nor 6‐amino‐2‐bromo‐3‐phenylpyridine are intermediates in the formation of the 2,6‐diamino derivative, as these bromo compounds are transformed in the basic medium into 1,3‐dicyano‐l‐phenylpropene. From both 2,6‐di‐chloro‐3‐dimethylamino‐ and 2,6‐dibromo‐3‐dimethylaminopyridine mixtures are obtained from which only 2‐amino‐l‐cyano‐l‐dimethylamino‐but‐l‐en‐3‐yne and 4‐amino‐6‐halogeno‐3‐dimethylaminopyridine were isolated.Mechanisms for the reactions studied are proposed, i.e. a SN(ANRORC) mechanism for the aminodebromination of 2,6‐dibromo‐3‐phenylpyridine into the corresponding 2,6‐diamino compound.
Mannich base derivatives of bioactive benzyl‐1,3‐benzodioxo‐5‐ols
Authors: Jurd Leonard 
Published: April 2009

Abstract3,4‐Methylenedioxyphenol (sesamol) reacts with equimolecular quantities of an aromatic aldehyde and morpholine or piperidine in methanol to give Mannich bases 7 and 8, related to insect growth regulators and anti‐leukemic and antimitotic benzyl‐1,3‐benzodioxole derivatives.
Réaction de l'acide chromone‐2 carboxylique avec les carbodiimides: Synthèse de spiro [(chromanone‐4)‐2: 5′‐hydantoïnes]
Authors: Filliatre Claude , Servens Et Christian 
Published: April 2009

AbstractLa réaction de l'acide chromone‐2 carboxylique avec des carbodiimides donne des N‐acylurées. Ces N‐acylurées se cyclisent facilement pour conduire aux spirochromanones correspondantes.
New synthesis of 5,6,7,8‐tetrahydro‐4H‐thieno[2,3‐d]azepine
Authors: Fréhel Daniel , Badorc Alain , Pereillo Jean‐Marie , Maffrand Jean‐Pierre 
Published: April 2009

AbstractThis paper describes two new access routes to 5,6,7,8‐tetrahydro‐4H‐thieno[2,3‐d]azepine from 2‐(2‐thienyl)ethylamine or its N‐(2‐chlorobenzyl) derivative. One of these two syntheses involves a new ring expansion from a 6,7‐dihydro[3,2‐c]pyridinium derivative, chloromethylated in position 4.
Substitution in the hydantoin ring. Part IX. N‐cyanohydantoins
Authors: Zinczuk Juan , Orazi Orfeo O. , Corral Renée A. , Roncaglia Hugo 
Published: April 2009

AbstractThe N1‐and N3‐cyanohydantoins, a new series of derivatives, were prepared by reaction of the parent hydantoin with a base and a cyanogen halide. Analysis of ir, pmr, and mass spectral data allowed the assignment of ring position‐3 to the cyano group in derivatives IIa,b of 1,3‐unsubstituted hydantoins. 3‐Cyanohydantoins can transfer the cyano substituent to strong nucleophiles via an addition‐elimination process.
Synthetic antibacterials. VIII. 7‐(1′‐alkylhydrazino)‐1,8‐naphthyridines and related compounds
Authors: Nishigaki Sadao , Mizushima Noriko , Kanazawa Hashime , Ichiba Misuzu , Senga Keitaro 
Published: April 2009

AbstractSynthesis and in vitro antibacterial activity of 7‐(1′‐alkylhydrazino)‐1,8‐naphthyridines related to nalidixic acid were investigated. Namely, treatment of 7‐alkylamino‐1‐ethyl‐1,4‐dihydro‐4‐oxo‐1,8‐naphthyridine‐3‐carboxylic acids 1a‐d with sodium nitrite in the presence of hydrochloric acid gave the 1‐ethyl‐1,4‐dihydro‐7‐(N‐nitrosoalkylamino)‐4‐oxo‐1,8‐naphthyridine‐3‐carboxylic acids 2a‐d, which upon reacting with zinc dust in acetic acid gave the 7‐(1′‐alkylhydrazino)‐1‐ethyl‐1,4‐dihydro‐4‐oxo‐1,8‐naphthyridine‐3‐carboxylicacids 3a‐d. The compound 3a was alternately obtained by the reaction of 7‐chloro‐1‐ethyl‐1,4‐dihydro‐4‐oxo‐1,8‐naphth‐yridine‐3‐carboxylic acid (4) with methylhydrazine. The reaction of 7‐chloro‐4‐hydroxy‐1,8‐naphthyridine‐3‐carboxylic acid (5) with methylhydrazine gave the 4‐hydroxy‐7‐(1′‐methylhydrazino)‐4‐oxo‐1,8‐naphthyridine‐3‐carboxylic acid (6), which upon treatment with alkyl halides afforded the 1‐alkyl‐1,4‐dihydro‐7‐(1′‐methyl‐hydrazino)‐4‐oxo‐1,8‐naphthyridines 3a and 3e‐g. The reaction of the appropriate 3 with ketones gave the corresponding 7‐(1′‐methylalkylidenehydrazino)‐1,8‐naphthyridines 7a‐c and 8a‐b. Among the compounds prepared, certain 3 and 7 exhibited good activity against Gram‐negative bacteria.
A regiospecific synthesis of 1‐methylamino‐6‐fluoro‐7‐(4‐methylpiperazin‐1‐yl)‐1,4‐dihydro‐4‐oxoquinoline‐3‐carboxylic acid
Authors: Chu Daniel T. W. 
Published: April 2009

AbstractAn efficient and regiospecific synthesis of 1‐methylamino‐6‐fluoro‐7‐(4‐methylpiperizin‐1‐yl)‐1,4‐dihydro‐4‐oxoquinoline‐3‐carboxylic acid (3) via an intramolecular nucleophilic displacement cyclization reaction is reported.
Syntheses of isomers of protoporphyrin‐IX with permuted propionic side‐chains
Authors: Smith Kevin M. , Pandey Ravindra K. 
Published: April 2009

AbstractTotal syntheses of hemins with permutations of the propionic side‐chains in the C and D rings (compared with protoporphyrin‐IX) are described. The products, 3, 2 and 4, are the dimethyl esters of protoporphyrins ‐I, ‐XI, and ‐XIV, respectively. They are of interest in connection with nmr studies designed to elucidate the structural features of the heme crevice in myoglobin and the effect of structural modifications of the C and D rings on the kinetics of heme‐apoprotein reconstitutions, as well as studies of substrate specificity of the heme degradation enzyme, heme oxygenase.
Synthesis of new 1,2,4‐triazolo[4,3‐b]pyridazines and related compounds
Authors: Sircar Ila 
Published: April 2009

AbstractThe synthesis of novel 6‐[4‐(1H‐imidazol‐1‐yl)phenyl]‐1,2,4‐triazolo[4,3‐b]pyridazines 8a‐f and related compounds is described. Although the intermediate hydrazine derivatives 7 and 9 possess good positive inotropic activity, the fused bicyclic pyridazines 8a‐f are significantly less potent than the 3(2H)‐pyridazinone 5. Compounds 8a‐f are potent but nonselective inhibitors of cardiac phosphodiesterase.
The reactivity of 2,3‐diaminopyridine toward alkyl chloroformates and dicarbonates
Authors: Zecchini Giampiero Pagani , Torrini Ines , Paradisi Mario Paglialunga 
Published: April 2009

AbstractThe reaction of 2,3‐diaminopyridine (DAP) with alkyl chloroformates and dialkyl dicarbonates is affected by the nature of the acylating agent and the acylation conditions. Mono and dicarbamates of DAP were obtained using chloroformates, while the formation of alkoxycarbonyl derivatives of imidazo[4,5‐b]pyridin‐2‐one was observed when the reaction with dicarbonates was performed at room temperature in THF‐pyridine. Our procedure for the synthesis of imidazopyridin‐2‐ones represents an improvement over the previous methods which require rather severe conditions. The revised structure for a monoacetyl derivative of the above bicyclic system is also reported.
The chemistry of 2H‐3,1‐benzoxazine‐2,4(1H)‐dione (isatoic anhydride). 18. A short synthesis of swietenidin A
Authors: Coppola Gary M. 
Published: April 2009

AbstractN‐Methylisatoic anhydrides react with the lithium enolate of ethyl methoxyacetate at low temperatures to produce intermediates which, when cyclized, afford 4‐hydroxy‐3‐methoxy‐2(1H)‐quinolinones. By this route, 3‐methoxy‐N‐methylisatoic anhydride (8) can be converted to the alkaloid swietenidin A (2) in 71% yield.
Synthesis and anticonvulsant evaluation of 1‐amino‐1,3‐dihydro‐2H‐benzimidazol‐2‐ones
Authors: Kornet M. J. , Beaven W. , Varia T. 
Published: April 2009

Abstract1‐Amino‐2‐benzimidazolinones containing alkyl substituents on the amino nitrogen have been prepared by the sodium bis (2‐methoxyethoxy)aluminum hydride reduction of 1‐acylamino‐2‐benzimidazolinones. The latter compounds were obtained in two steps from o‐nitro‐β‐acylphenylhydrazines. All of the 1‐amino‐2‐benzimidazolinones exhibited activity in the standard anticonvulsant tests except for the 1‐benzylamino compound. The most active compound was 1‐ethylamino‐2‐benzimidazolinone which protected mice in the maximal electroshock seizure test at 30 mg/kg.
The mass spectra of small‐ring heterocycles. IV
Authors: Tarburton Philip , Sun Tung , Gross Michael L. , Cromwell Norman H. 
Published: April 2009

AbstractBoth the high and low resolution mass spectra of fourteen isomeric trans‐ and cis‐aroylaziridines are presented. In contrast to earlier low resolution mass spectral work on these compounds [1], a new fragmentation pathway for the loss of hydroxyl is presented. Also, the simple fission of the N‐alkylnitrogen bond is described. Detailed fragmentation mechanisms are presented and discussed for the major ions found in the mass spectra.
Synthesis of 4,5‐dihydro‐4‐phenyl‐3H‐1,3,4‐benzotriazepines
Authors: Martin Lawrence L. , Agnew Marc N. , Setescak Linda L. 
Published: April 2009

AbstractSeveral 4,5‐dihydro‐4‐phenyl‐3H‐1,3,4‐benzotriazepines were synthesized by conversion of 1‐[(2‐nitrophenyl)methyl]‐1‐phenylhydrazine to either 1‐[(2‐aminophenyl)methyl]‐1‐phenylhydrazine or 1‐[(2‐aminophenyl)‐methyl]‐2‐methyl‐1‐phenylhydrazine. Ring closure of these intermediates with triethyl orthoacetate or triethyl orthopropionate gave the title compounds in overall yields of 40‐60%.
Synthesis and X‐Ray crystal structure of a 2,4,5‐trisubstituted 1,2,4‐triazolin‐3‐one
Authors: Madding Gary D. , Smith David W. , Sheldon Robert I. , Lee B. 
Published: April 2009

AbstractThe synthesis and x‐ray crystal structure of BMY 13754, a 1,2,4‐triazolin‐3‐one under clinical evaluation as an antidepressant agent, is described. Several synthetic strategies are discussed.
Synthesis of some 3‐alkenyl‐4‐oxo‐6,7‐dihydro‐4H‐pyrano[3,4‐d]isoxazoles
Authors: Chantegrel Bernard , Nadi Abdel‐Ilah , Gelin Suzanne 
Published: April 2009

AbstractA series of 3‐alkenyl‐4‐oxo‐6,7‐dihydro‐4H‐pyrano[3,4‐d]isoxazole derivatives was prepared by reaction of hydroxylamine with 4,5‐dioxo‐2,3,7,8‐tetrahydro‐4H,5H‐pyrano[4,3‐b]pyran derivatives.
Synthesis of the 7‐deaza and 5‐aza‐7‐deaza purine analogs of the antiherpes agent 9‐[(1,3‐dihydroxy‐2‐propoxy)methyl]guanine (DHPG)
Authors: Mcgee Danny P. C. , Martin John C. , Verheyden Julien P. H. 
Published: April 2009

AbstractSynthesis of 2‐amino‐7‐[(1,3‐dihydroxy‐2‐propoxy)methyl]pyrrolo[2,3‐d]pyrimidin‐4‐one (3) a 7‐deaza purine analogue and 2‐amino‐8‐[(1,3‐dihydroxy‐2‐propoxy)methyl]imidazo[1,2‐a]‐s‐triazin‐4‐one (4) a 5‐aza‐7‐deaza purine analogue of DHPG (2) are reported.
Base strengths and polarographic behaviour of a number of pyrazine derivatives
Authors: Gumbley Stewart J. , Lee T. W. S. , Stewart Ross 
Published: April 2009

AbstractThe pK1 and pK2 values and the Polarographic half‐wave reduction potentials for a series of methyl substituted pyrazines are reported, together with the reduction potentials of several of their N‐alkyl derivatives. There is a linear inverse relationship between pK1 and E1/2 for the pyrazines.
Synthesis of some 2‐(heteroarylamino)benzimidazoles and their cyclization with phosgene
Authors: Bossio Ricardo , Marcaccini Stefano , Parrini Valerio , Pepino Roberto 
Published: April 2009

Abstract2‐(Benzimidazol‐2‐ylamino)pyridine (4a), 2‐(benzimidazol‐2‐ylamino)pyrazine (4b), and 2‐(benzimidazol‐2‐ylamino)thiazole (4c) underwent a ring‐closure reaction on treatment with phosgene affording 6H‐pyrimido‐[1′,2′:5,4][1,3,5]triazino[1,2‐a]benzimidazol‐6‐one (1a), 6H‐pyrazino[1′,2′:5,4][1,3,5]triazino[1,2‐a]benzimidazol‐6‐one (1b), and 5H‐thiazolo[2′,3′:4,5][1,3,5]triazino[1,2‐a]benzimidazol‐5‐one (1c) respectively. The structure of these hitherto unknown heterocyclic systems was confirmed by their ir and mass spectra.
New agents for alkoxycarbonylation of amines
Authors: Ohta Akihiro , Inagawa Yukiko , Inoue Masami , Shimazaki Makoto , Mamiya Yukari 
Published: April 2009

AbstractAlkoxycarbonylated pyrazinols and pyrazinethiols were prepared. These compounds were shown to be convenient agents for alkoxycarbonylation of aliphatic amines.
Elektronenreiche olefine mit pyran‐4‐yliden‐einheit
Authors: Krasuski Witold , Regitz Manfred 
Published: April 2009

AbstractFür die Synthese der bisher unbekannten elektronenreichen Olefine mit einer Pyran‐4‐yliden‐Einheit werden zwei Wege beschritten:1) Pyryliumsalze (6a‐c) werden mit 2‐Piperidino‐1,3‐dithiolen (5a,b) zu 2‐(Pyran‐4‐yliden)‐1,3‐dithiolen (7a‐f) in Acetonitril bei 70° kondensiert. Auf analogem Wege werden die 2‐(Pyran‐4‐yliden)‐1,3,4‐thiadiazoline 13a‐f erhalten.2) Pyryliumsalze (6a‐c) werden über die (Pyran‐4‐yl)‐phosphoniumsalze 8a‐c in die (Pyran‐4‐yliden)‐phosphorane 9a‐c umgewandelt, die mit Dithioliumsalzen (10a,b) die Olefine 7a,c,e und g‐i liefern. Umsetzung von 9a,b mit den Thiadiazoliumsalzen 14a,b macht 13a‐c zugänglich.
Synthesis of 2‐isopropylidenehydrazinylthiazole and its subsequent annelation to the corresponding thiazolo[2,3‐c]‐s‐triazole
Authors: Houssin Raymond , Bernier Jean‐Luc , Hénichart Jean‐Pierre 
Published: April 2009

AbstractAn unequivocal synthesis of a new thiazolo[2,3‐c]‐s‐triazole substituted at the C‐5 position by a very useful methyl triphenylphosphonium salt has been achieved starting from the corresponding 2‐isopropylidenehydrazinylthiazole and formic acid. Ring closure was found to be very easy without isolation of a formylhydrazino intermediate. The thiazole derivative was prepared from isopropylidenethiosemicarbazide and (3‐chloro‐2‐oxo)propyltriphenylphosphonium chloride in a good yield.
Addition of 3‐thienyllithium to phthalic anhydride: A simple method for the synthesis of 9,10‐dihydro‐4H‐benzo[4,5]cyclohepta[1,2‐b]thiophen‐10‐one
Authors: Majchrzak Michal W. 
Published: April 2009

AbstractAddition of 3‐thienyllithium to phthalic anhydride produces a mixture of materials from which 2‐(3‐thienoyl)benzoic acid was easily separated. Elaboration of the acid side chain and ring closure produced the title compound in good yield.
Synthesis of 2‐(1‐methyl‐4‐piperylid‐3‐ene)‐9,10‐dihydro‐4H‐benzo[4,5]‐ cyclohepta[1,2‐b]thiophen‐10‐one, a new potential antiasthmatic analogue of zaditene
Authors: Majchrzak Michal W. 
Published: April 2009

AbstractThe title compound has been prepared in four steps from readily available starting material. The key reaction is the metallation of 10‐methoxy‐4H‐benzo[4,5]cyclohepta[1,2‐b]thiophene, which occurs exclusively at the desired 2 position.
Bromination of sydnones. II Bromination of 3‐(2‐aminophenyl)sydnone and related compounds
Authors: Hodson Stephen J. , Turnbull Kenneth 
Published: April 2009

AbstractBromination of 3‐(2‐aminophenyl)sydnone 2 under a variety of conditions is reported. The products obtained are interrelated by a series of subsequent reactions. One major product is the bromoaryl compound 8, the first example of bromination on the aryl rather than sydnone ring when the two are in competition. Surprisingly, bromoaminosydnone 9, prepared from its nitro analogue, was not among the products obtained by direct bromination of 2.
Synthesis of 8‐substituted naphtho[2,1‐b]thiophenes with cationic side chains at position 4
Authors: Kusuma Srihari , Wilson W. David , Boykin David W. 
Published: April 2009

AbstractA series of five 8‐substituted α‐[bis(2‐hydroxyethyi)aminoethyl]naphtho[2,1‐b]thiophenes 7 and a series of seven N‐(3‐dimethylaminopropyl)‐8‐substituted naphtho[2,1‐b]thiophene‐4‐carboxamides 8 have been synthesized. The naphtho[2,1‐b]thiophene‐4‐carboxylic acids 4 were prepared by photooxidative cyclization of α‐(2‐thienyi)‐β‐arylacrylic acids 3. The carboxylic acids 4 were converted by a conventional five step route involving α‐bromoketone intermediates to the a‐[bis(2‐hydroxyethyl)aminomethyl]‐8‐substituted naphtho‐[2,1‐6]thiophene‐4‐methanols 7 and by a standard two‐step amide preparation to the N‐(3‐dimethylaminopropyl)‐8‐substituted naphtho[2,1‐6]thiophene‐4‐carboxamides 8.
Chemistry of thienopyridines. XXXIII. Synthetic routes to 5‐ and 7‐substituted thieno[3,2‐b]pyridines from the N‐oxide
Authors: Klemm L. H. , Louris John N. , Boisvert William , Higgins Clay , Muchiri Daniel R. 
Published: April 2009

AbstractThieno[3,2‐b]pyridine (1) is oxidized to N‐oxide 1a by means of m‐chloroperoxybenzoic acid (83%). Compound 1a forms adducts with hydrogen chloride and picric acid and gives ring substitution alpha or gamma to the heteronitrogen atom. Thus, 1a plus nitric and sulfuric acids produces the 7‐nitro‐N‐oxide 1m (63%), or plus phosphorus oxychloride gives a mixture of 5‐chloro and 7‐chloro (1j) derivatives of 1. Compound 1m is convertible into a variety of other derivatives of 1, viz. 7‐chloro‐N‐oxide, 1j, 7‐bromo‐N‐oxide, 7‐nitro and 7‐amino. 5‐Cyano‐1, formed from 1a, is, in turn, transformed into a methyl imidate (93%), cyclic amidines, and a 5‐tetrazolyl‐1 (91%). These results confirm the prediction that 1a, thieno[2,3‐b]pyridine‐4‐oxide and quinoline 1‐oxide should exhibit closely similar (i.e. analogous) chemical reactions.
Nitrogen bridgehead compounds. Part 51 Autoxidation of 9‐aminotetrahydro‐4H‐pyrido[1,2‐a]pyrimidin‐4‐ones. Synthesis and stereochemistry of 9‐amino‐ and 9‐hydroxy‐6,7‐dihydro‐4H‐pyrido[1,2‐a]‐pyrimidin‐4‐ones
Authors: Breining Tibor , Hermecz István , Podányi Benjamin , Sessi John 
Published: April 2009

AbstractIn solution the 9‐phenylaminotetrahydro‐4H‐pyrido[1,2‐a]pyrimidin‐4‐ones 1‐5 were oxidized into the 9‐aminodihydro compounds 15‐19 by atmospheric oxygen at ambient temperature. Autoxidation is most probably a free‐radical chain process, which takes place with ground‐state triplet oxygen via the radical cation of the enamine form. The 9‐aminodihydro derivatives were also prepared from 9,9‐dibromo compounds 10 and 11 and from 9‐hydroxydihydro compounds 12‐14. The 9‐hydroxydihydro derivatives, obtained from the 9‐amino compounds 16, 19 and 21 by acidic hydrolysis, showed a solvent‐dependent and R1 substituent‐dependent oxo‐enol tautomerism. The enol form was stabilized by electron‐withdrawing R1 groups and a polar solvent. However, for the 9‐aminodihydropyrido[1,2‐a]pyrimidines 15‐26 only the enamine tautomer (E) could be identified independently of the substituent and the solvent. The chemical structures of the synthesized products were studied by uv, ir, 1H‐ and 13C‐nmr spectroscopy.
Synthesis of 2‐thiobenzimidazole derivatives as potential antifilarial agents
Authors: Ram Siya , Wise Dean S. , Townsend Leroy B. 
Published: April 2009

AbstractSeveral 5‐benzoyl‐2‐thiobenzimidazole and 2‐thiobenzimidazole aliphatic acids, esters, and N,N‐dialkyl‐carboxamides and thiocarboxamides were prepared by reacting bromo aliphatic acids, bromo aliphatic esters, and N,N‐dialkylcarbamoyl or thiocarbamoyl chlorides with 5‐benzoyl‐2‐thiobenzimidazole or 2‐thiobenzimidazole in the presence of base. 2‐Thiocarbomethoxy‐ and 2‐thiocarboethoxybenzimidazole were prepared by the reaction of 2‐thiobenzimidazole with methyl or ethyl chloroformate in the presence of base. However, the reaction of 5‐benzoyl‐2‐thiobenzimidazole with ethyl chloroformate, afforded 5‐benzoyl‐2‐ethylthiobenz‐imidazole.
Synthesis and properties of some 7‐dimethylamino‐1,4‐benzoxazin‐2‐ones
Authors: Le Bris Marie‐Thérèse 
Published: April 2009

AbstractThe synthesis of the 7‐dimethylamino‐1,4‐benzoxazin‐2‐ones (5), fluorescent dyes, by condensing α‐keto‐acids with 2‐amino‐5‐dimethylaminophenol is described. When the 3‐substituent is a methyl group, these compounds can be further condensed with aromatic aldehydes to provide the styryl dyes (6). These products are easily opened by hydrochloric acid in ethanolic solution to afford the corresponding benzalketoacid ethyl esters (7).
Synthèse d'analogues azotés d'esters chrysanthémiques et pyréthriques
Authors: Expert Jacques , Gelas‐Mialhe Yvonne , Vessière Roger 
Published: April 2009

AbstractLes diméthyl‐3,3 vinyl‐2 éthoxycarbonyl‐1 aziridines sont préparées par action de phosphoranes, phospho‐nate ou α‐triméthylsilylcarbanion sur des acyl‐2 aziridines. Nous décrivons également la synthèse d'une diméthyl‐3,3 éthoxycarbonyl‐2N‐vinylaziridine. Ces composés constituent des analogues des esters chrysanthémiques et pyréthriques.
Reaction of 2,5‐diisopropyl‐ and 2,5‐di‐sec‐butylpyrazine 1‐oxide. Derivatives with phosphoryl chloride and acetic anhydride
Authors: Inoue Masami , Abe Reiko , Tamamura Hideo , Ohta Minoru , Asami Keiko , Kitani Hisayuki , Kamei Hideko , Nakamura Yumiko , Watanabe Tokuhiro , Ohta Akihiro 
Published: April 2009

AbstractIn order to examine the α‐substitution of side chains, various derivatives of 2,5‐diisopropyl‐ and 2,5‐disec‐butylpyrazine 1‐oxides were subjected to the reaction with phosphoryl chloride and acetic anhydride. Chlorination and acetoxylation were recognized to take place on the pyrazine ring in almost all cases.
Cesium fluoride assisted synthesis of macrocyclic polyethers with aromatic subunits
Authors: Czech Bronislaw P. , Czech Anna , Bartsch Richard A. 
Published: April 2009

AbstractSeveral features of the synthesis of crown ethers with aromatic subunits by reactions of dihydroxyaromatic or bis(hydroxyaromatic) compounds with cesium fluoride and polyethylene glycol tosylates are explored. The method is utilized to prepare several new crown ethers and to synthesize known crown compounds in improved yields.
Synthèse d'azamacrocycles polysubstitués par des peptides biologiquement actifs
Authors: Kraus Jean Louis 
Published: April 2009

AbstractDans le but d'étudier le phénomène de clustérisation des récepteurs membranaires, nous rapportons la Synthèse de nouveaux dérivés tétraazacycloalkanes substitués par l'intermédiaire d'intercalateurs à des peptides (N‐formyl‐Met‐Leu‐Phe)biologiquement actifs.
Preparation and reactions of mono‐reissert compounds and analogs at the 3,4‐position of quinazoline
Authors: Kant Joydeep , Popp Frank D. , Uff Barrie C. 
Published: April 2009

AbstractQuinazoline, acid chlorides, and trimethylsilyl cyanide have been converted to mono‐Reissert compounds at the 3,4‐position of the quinazoline system. Various reactions of these quinazoline Reissert compounds are reported.
Reactions of 2,3‐diamino‐4(3H)‐pyrimidinones. II
Authors: Hlavka Joseph J. , Bitha Panayota , Lin Yang‐I , Strohmeyer Timothy 
Published: April 2009

AbstractThe reaction of 2,3‐diamino‐4(3H)‐pyrimidinones with α,β‐diketones and orthoesters is described.
The nitration of 3,5‐ and 2,6‐diphenyl‐4‐pyrone
Authors: Katritzky Alan R. , Faid‐Allah Hassan 
Published: April 2009

Abstract3,5‐Diphenyl‐4‐pyrone is nitrated in the phenyl groups under different conditions ortho and/or para to yield the 2′,2″‐di‐, the 4′,4″‐di‐, and the 2′,2″,4′,4″‐tetranitro derivatives. 2,6‐Diphenyl‐4‐pyrone undergoes meta nitration to give the 3′,3″‐dinitro derivative.
Synthèse d'analogues furannique et nitro‐2 furannique du benzo[e]pyrène
Authors: Demerseman Pierre , Trie Bernadette , Royer René , Strapélias Hélène 
Published: April 2009

AbstractLe pyréno[4,5‐b]furanne et le nitro‐10 pyréno[4,5‐b]furanne sont obtenus à partir du formyl‐5 hydroxy‐4 pyrène qui est lui‐měme préparé, en six étapes, à partir du pyrène.