bluuebunny/crossref_metadata_2025_split huggingface dataset:
Coeliac disease and type 2 diabetes risk: a nationwide matched cohort and Mendelian randomisation study
Authors: Yuan Shuai , Leffler Dan , Lebwohl Benjamin , Green Peter H. R. , Sun Jiangwei , Carlsson Sofia , Larsson Susanna C. , Ludvigsson Jonas F. 
Published: May 2024

Abstract
Aims/hypothesis
While the association between coeliac disease and type 1 diabetes is well documented, the association of coeliac disease with type 2 diabetes risk remains undetermined. We conducted a nationwide cohort and Mendelian randomisation analysis to investigate this link.

Methods
This nationwide matched cohort used data from the Swedish ESPRESSO cohort including 46,150 individuals with coeliac disease and 219,763 matched individuals in the comparator group selected from the general population, followed up from 1969 to 2021. Data from 9053 individuals with coeliac disease who underwent a second biopsy were used to examine the association between persistent villous atrophy and type 2 diabetes. Multivariable Cox regression was employed to estimate the associations. In Mendelian randomisation analysis, 37 independent genetic variants associated with clinically diagnosed coeliac disease at p<5×10−8 were used to proxy genetic liability to coeliac disease. Summary-level data for type 2 diabetes were obtained from the DIAGRAM consortium (80,154 cases) and the FinnGen study (42,593 cases).

Results
Over a median 15.7 years’ follow-up, there were 6132 (13.3%) and 30,138 (13.7%) incident cases of type 2 diabetes in people with coeliac disease and comparator individuals, respectively. Those with coeliac disease were not at increased risk of incident type 2 diabetes with an HR of 1.00 (95% CI 0.97, 1.03) compared with comparator individuals. Persistent villous atrophy was not associated with an increased risk of type 2 diabetes compared with mucosal healing among participants with coeliac disease (HR 1.02, 95% CI 0.90, 1.16). Genetic liability to coeliac disease was not associated with type 2 diabetes in DIAGRAM (OR 1.01, 95% CI 0.99, 1.03) or in FinnGen (OR 1.01, 95% CI 0.99–1.04).

Conclusions/interpretation
Coeliac disease was not associated with type 2 diabetes risk.

Graphical Abstract
In vivo demonstration of globotriaosylceramide brain accumulation in Fabry Disease using MR Relaxometry
Authors: Pontillo Giuseppe , Tranfa Mario , Scaravilli Alessandra , Monti Serena , Capuano Ivana , Riccio Eleonora , Rizzo Manuela , Brunetti Arturo , Palma Giuseppe , Pisani Antonio , Cocozza Sirio 
Published: May 2024

Abstract
Purpose
How to measure brain globotriaosylceramide (Gb3) accumulation in Fabry Disease (FD) patients in-vivo is still an open challenge. The objective of this study is to provide a quantitative, non-invasive demonstration of this phenomenon using quantitative MRI (qMRI).

Methods
In this retrospective, monocentric cross-sectional study conducted from November 2015 to July 2018, FD patients and healthy controls (HC) underwent an MRI scan with a relaxometry protocol to compute longitudinal relaxation rate (R1) maps to evaluate gray (GM) and white matter (WM) lipid accumulation. In a subgroup of 22 FD patients, clinical (FAbry STabilization indEX -FASTEX- score) and biochemical (residual α-galactosidase activity) variables were correlated with MRI data. Quantitative maps were analyzed at both global (“bulk” analysis) and regional (“voxel-wise” analysis) levels.

Results
Data were obtained from 42 FD patients (mean age = 42.4 ± 12.9, M/F = 16/26) and 49 HC (mean age = 42.3 ± 16.3, M/F = 28/21). Compared to HC, FD patients showed a widespread increase in R1 values encompassing both GM (pFWE = 0.02) and WM (pFWE = 0.02) structures. While no correlations were found between increased R1 values and FASTEX score, a significant negative correlation emerged between residual enzymatic activity levels and R1 values in GM (r = -0.57, p = 0.008) and WM (r = -0.49, p = 0.03).

Conclusions
We demonstrated the feasibility and clinical relevance of non-invasively assessing cerebral Gb3 accumulation in FD using MRI. R1 mapping might be used as an in-vivo quantitative neuroimaging biomarker in FD patients.
Cardiac and Liver Fibrosis Assessed by Multiparametric MRI in Patients with Fontan Circulation
Authors: Innocenzi Adriana , Rangel Isabela , Póvoa-Corrêa Mariana , Parente Daniella Braz , Perez Renata , Rodrigues Rosana Souza , Fukuyama Lúcia Tomoko , Barroso Julia Machado , Oliveira Neto Jaime Araújo , Silvestre de Sousa Andréa , Luiz Ronir Raggio , Barbosa Rosa Célia Pimentel , Camargo Gabriel Cordeiro , Moll-Bernardes Renata 
Published: May 2024

AbstractThe abnormal hemodynamics in Fontan circulation due to persistently increased systemic venous pressure results in hepatic venous congestion and Fontan-associated liver disease. Combined assessment of cardiac and liver fibrosis and cardiac remodeling using multiparametric MRI in this context have not been fully explored. To evaluate cardiac and liver fibrosis and cardiac remodeling using multiparametric MRI in patients who have undergone Fontan procedures. Thirty-eight patients and 23 controls underwent cardiac and liver MRI examinations in a 3.0-T scanner. Mann–Whitney, Fisher exact test, and Spearman’s correlation were applied to evaluate myocardial volumes, function, native cardiac and liver T1 mapping, ECVs and liver stiffness. The mean native cardiac T1 value (p = 0.018), cardiac ECV (p < 0.001), liver native T1 (p < 0.001), liver ECV (p < 0.001), and liver stiffness (p < 0.001) were higher in patients than controls. The indexed end-diastolic volume (EDVi) correlated with the myocardial ECV (r = 0.356; p = 0.033), native liver T1 (r = 0.571; p < 0.001), and with liver stiffness (r = 0.391; p = 0.015). In addition, liver stiffness correlated with liver ECV (r = 0.361; p = 0.031) and native liver T1 (r = 0.458; p = 0.004). An association between cardiac remodeling and cardiac and liver fibrosis were found in this population. The usefulness of MRI to follow cardiac and liver involvement in these patients is critical to improve treatment strategies and to prevent the need for combined liver and heart transplantation.
Improving the mechanical and abrasion properties of silica-reinforced styrene-butadiene rubber composites by optimizing the concentrations of compatibilizers
Authors: Sayfo Petra , Pölöskei Kornél , Mészáros László 
Published: May 2024

AbstractSilica (chemical formula SiO2) is a promising, more environmentally friendly alternative to carbon black (CB) used in the rubber industry as a filler. Although silica is already used in rubber products, it is not used as extensively as CB because the polar surface of silica cannot interact well with the apolar polymer molecules of the most frequently used rubbers. To solve this problem, experts have tried different grafting methods and several coupling agents for a stronger silica-elastomer connection. In this article, we used bis[3-(triethoxysilyl)propyl] tetrasulfide (TESPT) and polyethylene glycol (PEG) combined to improve the connection between the surface of silica and the apolar styrene-butadiene rubber (SBR) matrix. We examined mechanical and structural properties and found that adding 3 phr PEG and 4.5 phr TESPT to SBR is optimal for 60 phr silica content. This ratio of additives resulted in a 48% improvement in tensile strength. The positive effect of the coupling agents shows up in abrasion mass loss and tear strength as well.
The influence of APOEε4 on the pTau interactome in sporadic Alzheimer’s disease
Authors: Thierry Manon , Ponce Jackeline , Martà-Ariza Mitchell , Askenazi Manor , Faustin Arline , Leitner Dominique , Pires Geoffrey , Kanshin Evgeny , Drummond Eleanor , Ueberheide Beatrix , Wisniewski Thomas 
Published: May 2024

AbstractAPOEε4 is the major genetic risk factor for sporadic Alzheimer’s disease (AD). Although APOEε4 is known to promote Aβ pathology, recent data also support an effect of APOE polymorphism on phosphorylated Tau (pTau) pathology. To elucidate these potential effects, the pTau interactome was analyzed across APOE genotypes in the frontal cortex of 10 advanced AD cases (n = 5 APOEε3/ε3 and n = 5 APOEε4/ε4), using a combination of anti-pTau pS396/pS404 (PHF1) immunoprecipitation (IP) and mass spectrometry (MS). This proteomic approach was complemented by an analysis of anti-pTau PHF1 and anti-Aβ 4G8 immunohistochemistry, performed in the frontal cortex of 21 advanced AD cases (n = 11 APOEε3/ε3 and n = 10 APOEε4/ε4). Our dataset includes 1130 and 1330 proteins enriched in IPPHF1 samples from APOEε3/ε3 and APOEε4/ε4 groups (fold change ≥ 1.50, IPPHF1vs IPIgG ctrl). We identified 80 and 68 proteins as probable pTau interactors in APOEε3/ε3 and APOEε4/ε4 groups, respectively (SAINT score ≥ 0.80; false discovery rate (FDR) ≤ 5%). A total of 47/80 proteins were identified as more likely to interact with pTau in APOEε3/ε3 vs APOEε4/ε4 cases. Functional enrichment analyses showed that they were significantly associated with the nucleoplasm compartment and involved in RNA processing. In contrast, 35/68 proteins were identified as more likely to interact with pTau in APOEε4/ε4 vs APOEε3/ε3 cases. They were significantly associated with the synaptic compartment and involved in cellular transport. A characterization of Tau pathology in the frontal cortex showed a higher density of plaque-associated neuritic crowns, made of dystrophic axons and synapses, in APOEε4 carriers. Cerebral amyloid angiopathy was more frequent and severe in APOEε4/ε4 cases. Our study supports an influence of APOE genotype on pTau-subcellular location in AD. These results suggest a facilitation of pTau progression to Aβ-affected brain regions in APOEε4 carriers, paving the way to the identification of new therapeutic targets.
Intermediate-term impact on corneal endothelial cells and efficacy of Preserflo MicroShunt implantation in patients with open-angle glaucoma – a prospective study over two years
Authors: Gassel Caroline J. , Wenzel Daniel A. , Nasyrov Emil , Strasser Torsten , Voykov Bogomil 
Published: May 2024

Abstract
Introduction
Preserflo MicroShunt is a novel microinvasive bleb forming device for the treatment of primary open-angle glaucoma. The intermediate- and long-term success and the impact of this procedure on corneal endothelial cell density remain to be investigated.

Methods
In this prospective observational study, 62 eyes of 55 glaucoma patients (mean age ± SD: 67.0 ± 15.0 years) receiving a Preserflo MicroShunt were included. Corneal endothelial cell density, intraocular pressure and best corrected visual acuity were assessed preoperatively and at 3, 6, 9, 12, 18 and 24 months postoperatively. Success rates, bleb revision rates and complications were analysed. Complete success was defined as an intraocular pressure reduction of ≥ 20% and achieving a target pressure of ≤ 18, ≤ 15 or ≤ 12 mmHg without antiglaucoma medication. Qualified success indicated that the criteria were reached with or without medication.

Results
Corneal endothelial cells showed no significant decline over 24 months (p > 0.05). Intraocular pressure showed a substantial reduction postoperatively (p < 0.001), decreasing from 29.6 ± 8,3 mmHg to 13.0 ± 4.3 mmHg after 24 months (p < 0.001). Complete and qualified success with a target pressure ≤ 15 mmHg was achieved in 52.9% and 54.6% of cases after 24 months, respectively. Best corrected visual acuity did not change after 24 months.

Conclusion
Preserflo MicroShunt had no negative side effects on corneal endothelial cells and showed favourable success rates after 2 years in patients with open-angle glaucoma.
Long-term weight loss of distal gastric bypass is moderately superior compared to proximal gastric bypass in patients with a BMI of 37–44 Kg/m2
Authors: Cereser Teresa , Heil Jan , Schöb Othmar , Schlumpf Rolf , Gantert Walter A. , Infanger David , Böckmann Michael , Beissner Philippe , Bach-Kliegel Birgit , Potoczna Natascha , Schiesser Marc 
Published: May 2024

Abstract
Purpose
The laparoscopic Roux-en-Y gastric bypass (LRYGB) is one of the standard procedures in metabolic surgery. Different limb lengths have been proposed in the past to maximize weight loss (WL) and reduce metabolic complications. Distal gastric bypass surgery with a very short common channel (CC) (up to 100 cm) has been often criticized due to frequent side effects such as malnutrition, bone weakening and short-bowel syndrome. We introduced a modified version of a distal LRYGB with a 50–70 cm long biliopancreatic limb (BPL) and an intermediate short CC (120–150 cm). Our primary goal was to compare the long-term WL between distal and proximal LRYGB in two cohorts of patients. Secondary outcomes were weight regain (WR), insufficient weight loss (IWL), postoperative complications and metabolic changes 5 years after surgery.

Methods
In this retrospective study we collected data from 160 patients operated between 2014 and 2015, with a BMI of 37–44 Kg/m2. 101 patients underwent a distal and 59 patients a proximal LRYGB in two bariatric centers. WL was calculated as percent of excess of BMI loss (%EBMIL), loss of body mass index (Delta-BMI), percent of excess weight loss (%EWL) and percent of total weight loss (%TWL). Data were collected 3, 6, 9, 12, 24, 48 and 60 months after surgery.

Results
The distal LRYGB resulted in significantly better 5-year-WL compared to the proximal bypass in terms of %EBMIL (median at 5 years: 83% vs. 65%, p = 0.001), %TWL (median at 5 years: 32% vs. 26%, p = 0.017) and %EWL (median at 5 years: 65% vs. 51%, p = 0.029), with equal major complications and metabolic alterations. In addition, WR was significantly lower in patients with distal bypass (18% vs. 35%, p = 0.032).

Conclusions
Distal LYRGB with a 120–150 long CC results in better WL and WL-maintenance compared to proximal LRYGB without major side effects after five years.
Predictive models for treated clayey soils using waste powdered glass and expanded polystyrene beads using regression analysis and artificial neural network
Authors: Akis E. , Cigdem O. Y. 
Published: May 2024

AbstractWaste materials contribute to a wide range of environmental and economic problems. To minimize their effects, a safe strategy for reducing such negative impact is required. Recycling and reusing waste materials have proved to be effective measures in this respect. In this study, an eco-friendly treatment is investigated based on using waste powdered glass (WGP) and EPS beads (EPSb) as mechanical and chemical admixers in soils. For this purpose, Atterberg limit, standard proctor, free swell, and unconfined compression tests are performed on soil samples with different ratios of waste materials at their optimum moisture contents. The obtained test results indicate that adding WGP to cohesive soils increases the unconfined compressive strength (UCS) and reduces free swell (FS). In contrast, using EPSb reduces both FS and UCS of the treated soil samples. An optimum combination of both waste materials is determined for the improvement of the properties of high plasticity clay used in this study. Furthermore, multiple linear regression (MLR) and artificial neural network (ANN) methods are used to predict the FS and UCS of the clayey soils based on the data obtained here and the experimental test results reported in the literature. Once the FS and UCS values of untreated soil and additive percentages are defined as independent variables, both methods are shown to predict the FS and UCS values of the treated soil samples on a satisfactory level with the coefficient of correlation ($${R}^{2}$$

R

2

) values greater than 0.926. Additionally, when only the index properties (liquid limit, plastic limit, and plasticity index) of the soil samples with waste materials are used as dependent variables, the $${R}^{2}$$

R

2

values obtained by the ANN method are 0.968 and 0.974 for FS and UCS, respectively. The results of the untreated soil samples' FS and UCS tests are known, and the linear regression and ANN techniques yield similar results. Lastly, the ANN method is used to predict the FS and UCS of the treated samples in accordance to the limited predictors (e.g., only the Atterberg limits of the soil sample).
Fast computation of General SimRank on heterogeneous information network
Authors: Zhang Chuanyan , Hong Xiaoguang , Zheng Yongqing 
Published: May 2024

AbstractSimilarity computation is a fundamental aspect of information network analysis, underpinning many research tasks including information retrieval, clustering, and recommendation systems. General SimRank (GSR), an extension of the well-known SimRank algorithm, effectively computes link-based global similarities incorporating semantic logic within heterogeneous information networks (HINs). However, GSR inherits the recursive nature of SimRank, making it computationally expensive to achieve convergence through iterative processes. While numerous rapid computation methods exist for SimRank, their direct application to GSR is impeded by differences in their underlying equations. To accelerate GSR computation, we introduce a novel approach based on linear systems. Specifically, we transform the pairwise surfer model of GSR on HINs into a new random walk model on a node-pair graph, establishing an equivalent linear system for GSR. We then develop a fast algorithm utilizing the local push technique to compute all-pair GSR scores with guaranteed accuracy. Additionally, we adapt the local push method for dynamic HINs and introduce a corresponding incremental algorithm. Experimental results on various real datasets demonstrate that our algorithms significantly outperform the traditional power method in both static and dynamic HIN contexts.
A Credibility Framework for Extreme Value-at-Risk
Authors: Mitic Peter 
Published: May 2024

AbstractValue-at-risk estimates derived from extreme value data by fitting fat-tailed distributions can be so large that their validity is open to question. In this paper, an objective criterion, and a framework from which it was developed, are presented in order to decide whether or not a fitted distribution is inappropriate for the purpose of value-at-risk calculation. That criterion is based on established extreme value theory (principally the Pickands-Balkema-deHaan Theorem), which is used to calculate a sequence of reference value-at-risk estimates using Generalised Pareto distributions. Those estimates are used to develop a closed-form formula for calculating a theoretical ’maximum’ value-at-risk. The method is validated by generating 100 random data sets and testing them against the framework for varying input parameter values. Approximately 75% of those cases passed the validation test.
On a General Family of 2-Orthogonal Polynomial Eigenfunctions of a Third Order Differential Equation via Symbolic Computation
Authors: Mesquita Teresa Augusta 
Published: May 2024

AbstractThe search for 2-orthogonal polynomial eigenfunctions, with respect to a third order differential operator that does not increase the degree of polynomials, was recently developed in [23] by means of a symbolic approach. This work allowed us to establish some impossible cases as also to present a few families of such 2-orthogonal polynomial sequences. In this paper, we apply the symbolic setup proposed in [23] in order to enlighten us about further 2-orthogonal polynomial solutions of this problem. Concerning a general family inhere described, it is also proved its Hahn-classical character. Additionally, some functional identities are established.
Sensitivity of daily reference evapotranspiration to weather variables in tropical savanna: a modelling framework based on neural network
Authors: Gupta Sanjeev , Kumar Pravendra , Kishore Gottam , Ali Rawshan , Al-Ansari Nadhir , Vishwakarma Dinesh Kumar , Kuriqi Alban , Pham Quoc Bao , Kisi Ozgur , Heddam Salim , Mattar Mohamed A. 
Published: May 2024

AbstractAccurate prediction of reference evapotranspiration (ETo) is crucial for many water-related fields, including crop modelling, hydrologic simulations, irrigation scheduling and sustainable water management. This study compares the performance of different soft computing models such as artificial neural network (ANN), wavelet-coupled ANN (WANN), adaptive neuro-fuzzy inference systems (ANFIS) and multiple nonlinear regression (MNLR) for predicting ETo. The Gamma test technique was adopted to select the suitable input combination of meteorological variables. The performance of the models was quantitatively and qualitatively evaluated using several statistical criteria. The study showed that the ANN-10 model performed superior to the ANFIS-06, WANN-11 and MNLR models. The proposed ANN-10 model was more appropriate and efficient than the ANFIS-06, WANN-11 and MNLR models for predicting daily ETo. Solar radiation was found to be the most sensitive input variable. In contrast, actual vapour pressure was the least sensitive parameter based on sensitivity analysis.
Sustainability indicator for evaluating the ATES system in Halabja-Khurmal sub-basin NE-Iraq using GIS-based MCDA method
Authors: Rauf Lanja F. , Ali Salahalddin S. , Al-Ansari Nadhir , Nordell Bo 
Published: May 2024

AbstractThermal energy is utilized as an environmentally friendly energy source for seasonal heat and cold storage on a global scale. Specifically, the aquifer thermal energy storage system is highlighted for being cost-effective in cooling and heating applications. The study assesses the sustainability of the aquifer thermal energy storage in the Halabja-Khurmal sub-basin by evaluating six critical criteria: groundwater transmissivity, groundwater temperature, groundwater discharge, groundwater chemistry, population density, and per capita GDP. A multi-criteria decision analysis judgment is applied to analyze all criteria, resulting in a consistency ratio of 0.3% in the analytical hierarchy process. Consequently, the sustainability map for Aquifer Thermal Energy Storage in the Halabja-Khurmal sub-basin for heating reveals that 26.45% of the area is strongly sustainable located in the north and southwestern part of the sub-basin, 73.53% is moderate in the east, central, southeast, and southern regions, 0.02% is weakly sustainable as a tiny area in the southwestern. On the other hand, the sustainability map for Aquifer Thermal Energy Storage in the Halabja-Khurmal sub-basin for cooling reveals that 19% of the area is strongly sustainable located in the north, and southwestern parts of the sub-basin, 78% is moderate in the northeast, east, southeast, west, central, and southern regions, 3% is weakly sustainable as spots in the west and southwestern areas.