bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sex-specific associations of urinary mixed-metal concentrations with femoral bone mineral density among older people: an NHANES (2017–2020) analysis
Authors: Li Hecheng , Li Guoliang , Yi Mushi , Zhou Jiazhen , Deng Yaotang , Huang Yiqi , He Shuirong , Meng Xiaojing , Liu Lili 
Published: May 2024

BackgroundHeavy metal exposure is an important cause of reduced bone mineral density (BMD). Epidemiological studies focusing on the effects of mixed heavy metal exposure on BMD in middle-aged and older people are scarce. In single-metal studies, men and women have shown distinct responses of BMD to environmental metal exposure. This study therefore aimed to elucidate the association between mixed heavy metal exposure and BMD and to investigate whether it is sex-specific.MethodsData from the 2017–2020 National Health and Nutrition Examination Survey were selected for this cross-sectional study. The study used three statistical methods, i.e., linear regression, Bayesian kernel machine regression (BKMR) modeling, and weighted quartiles (WQS) regression, to explore the association between the urinary concentrations of 11 metals (barium, cadmium, cobalt, cesium, manganese, molybdenum, lead, antimony, tin, thallium, and Tungsten), either individually or as a mixture, and total femoral BMD.ResultsA total of 1,031 participants were included in this study. Femoral BMD was found to be higher in men than women. A significant negative correlation between the urinary concentrations of the 10 metals and femoral BMD was found in the overall cohort. Further gender sub-stratified analyses showed that in men, urinary metal concentrations were negatively correlated with femoral BMD, with cobalt and barium playing a significant and non-linear role in this effect. In women, although urinary metal concentrations negatively modulated femoral BMD, none of the correlations was statistically significant. Antimony showed sex-specific differences in its effect.ConclusionThe urinary concentrations of 10 mixed heavy metals were negatively correlated with femoral BMD in middle-aged and older participants, and this effect showed gender differences. These findings emphasize the differing role of mixed metal exposure in the process of BMD reduction between the sexes but require further validation by prospective studies.
Applications of natural language processing tools in the surgical journey
Authors: Le Khang Duy Ricky , Tay Samuel Boon Ping , Choy Kay Tai , Verjans Johan , Sasanelli Nicola , Kong Joseph C. H. 
Published: May 2024

BackgroundNatural language processing tools are becoming increasingly adopted in multiple industries worldwide. They have shown promising results however their use in the field of surgery is under-recognised. Many trials have assessed these benefits in small settings with promising results before large scale adoption can be considered in surgery. This study aims to review the current research and insights into the potential for implementation of natural language processing tools into surgery.MethodsA narrative review was conducted following a computer-assisted literature search on Medline, EMBASE and Google Scholar databases. Papers related to natural language processing tools and consideration into their use for surgery were considered.ResultsCurrent applications of natural language processing tools within surgery are limited. From the literature, there is evidence of potential improvement in surgical capability and service delivery, such as through the use of these technologies to streamline processes including surgical triaging, data collection and auditing, surgical communication and documentation. Additionally, there is potential to extend these capabilities to surgical academia to improve processes in surgical research and allow innovation in the development of educational resources. Despite these outcomes, the evidence to support these findings are challenged by small sample sizes with limited applicability to broader settings.ConclusionWith the increasing adoption of natural language processing technology, such as in popular forms like ChatGPT, there has been increasing research in the use of these tools within surgery to improve surgical workflow and efficiency. This review highlights multifaceted applications of natural language processing within surgery, albeit with clear limitations due to the infancy of the infrastructure available to leverage these technologies. There remains room for more rigorous research into broader capability of natural language processing technology within the field of surgery and the need for cross-sectoral collaboration to understand the ways in which these algorithms can best be integrated.
Microsurgical central lymphatic reconstruction—the role of thoracic duct lymphovenous anastomoses at different anatomical levels
Authors: Weinzierl Andrea , Grünherz Lisanne , Puippe Gilbert Dominique , Gnannt Ralph , von Reibnitz Donata , Giovanoli Pietro , Vetter Diana , Möhrlen Ueli , Wildgruber Moritz , Müller Andreas , Pieper Claus Christian , Gutschow Christian Alexander , Lindenblatt Nicole 
Published: May 2024

IntroductionIn recent years advances have been made in the microsurgical treatment of congenital or acquired central lymphatic lesions. While acquired lesions can result from any surgery or trauma of the central lymphatic system, congenital lymphatic lesions can have a variety of manifestations, ranging from singular thoracic duct abnormalities to complex multifocal malformations. Both conditions may cause recurrent chylous effusions and downstream lymphatic congestion depending on the anatomical location of the thoracic duct lesion and are associated with an increased mortality due to the permanent loss of protein and fluid.MethodsWe present a case series of eleven patients undergoing central lymphatic reconstruction, consisting of one patient with a cervical iatrogenic thoracic duct lesion and eleven patients with different congenital thoracic duct lesions or thrombotic occlusions.ResultsAnastomosis of the thoracic duct and a nearby vein was performed on different anatomical levels depending on the underlying central lymphatic pathology. Cervical (n = 4), thoracic (n = 1) or abdominal access (n = 5) was used for central lymphatic reconstruction with promising results. In 9 patients a postoperative benefit with varying degrees of symptom regression was reported.ConclusionThe presented case series illustrates the current rapid advances in the field of central microsurgical reconstruction of lymphatic lesions alongside the relevant literature.
Incidence of hand and wrist disorders in primary care: a retrospective cohort study
Authors: Krastman Patrick , de Schepper Evelien IT , Bindels Patrick JE , Bierma-Zeinstra Sita MA , Kraan Gerald , Runhaar Jos 
Published: May 2024

Background
The incidence of different types of hand and wrist disorders in primary care is unknown since there are no specific encodings for it.

Aim
To determine the overall incidence and the incidence of specific types of hand and wrist disorders in primary care.

Design & setting
A retrospective cohort study was undertaken, using a healthcare registration database from Dutch general practice, which contains medical records of more than 200 000 patients, and included approximately 25% of the population of the area of Rotterdam in The Netherlands.

Method
Patients aged ≥18 years with a new diagnosis of hand or wrist disorder from 1 January 2015–31 December 2019 were extracted using a search algorithm based on International Classification of Primary Care (ICPC) coding and search terms in free text.

Results
The mean incidence over the study period of a hand disorder was 5.9 per 1000 persons-years and of a wrist disorder 0.3 per 1000 persons-years. The incidence of trigger finger or thumb, hand or finger fracture, tendon or ligament tendinopathy, mallet finger, and hand or finger ligament injury were 3 (95% confidence interval [CI] = 2.69 to 3.15), 1 (95% CI = 1.03 to 1.33), 1 (95% CI = 0.98 to 1.28), 0.6 (95% CI = 0.48 to 0.69), and 0.1 (95% CI = 0.06 to 0.14) per 1000 persons-years, respectively. The incidence of a wrist fracture and ligament injury were 0.2 (95% CI = 0.13 to 0.25) and 0.1 (95% CI = 0.04 to 0.12) per 1000 persons-years, respectively.

Conclusion
There is a large difference between the number of patients presenting to the GP with hand and wrist complaints and the number of hand and wrist diagnoses reported in the medical files. Introducing specific ICPC codes for different types of hand and wrist disorders could (potentially) lead to a more accurate registration of a diagnosis and determination of the incidence figures.
Analisis Kualitas Website Stikes Garuda Putih Kota Jambi Menggunakan Metode Webqual 4.0
Authors: Syah Firman , Ahmad Husaein  , Ronald Naibaho  
Published: May 2024

Perkembangan IT yang pesat menjadikan website sebagai bagian yang tidak terpisahkan dari sebuah lembaga pendidikan khususnya dalam hal layanan bagi aktivitas akademika, dosen, mahasiswa, dan tenaga kependidikan. Layanan dalam suatu sistem informasi berbasis web perlu diukur untuk mengetahui tingkat kualitas website bagi pengguna. penelitian ini, untuk menentukan kualitas website STIKES Garuda Putih Kota Jambi dalam memenuhi kebutuhan penguna kepuasaan menggunakan metode webqual 4.0. Metode yang digunakan dalam menentukan kualitas website Stikes Garuda putih kota jambi adalah metode webqual 4.0 yang terdiri dari empat variabel yakni variable usability, information quality, interaction quality dan User Satisfaction. Sampel penelitian berjumlah 173 responden. Pengambilan sampel secara acak dan berstrata. Data dikumpulkan melalui angket berisi pernyataan tentang persepsi mahasiswa terhadap website SITKES Garuda Putih kota jambi. Data yang terkumpul diolah dengan SPSS serta melakukan uji untuk mengetahui kualitas website STIKES Garuda Putihkota jambi. Dari hasil perhitungan yang telah dilakukan oleh peneliti, diperoleh nilai variabel Intraction Quality lebih besar dibandingkan variabel Information Quality dan variabel Usability Quality, dengan begitu Variabel Intraction Quality memiliki pengaruh yang lebih besar daripada variabel yang lainnya, yang dapat dilihat dari nilai t hitung variabel Interaction Quality sebesar 5,946 dibadingkan nilai t hitung variabel Information Quality sebesar 1,510 dan variabel Usability Quality sebesar 2,838.

Daftar Pustaka (2015-2022)
The editions on historical and natural sciences 1923 year as a source of formation of Ukrainian museum work
Authors: Kepin Dmytro 
Published: May 2024

The article analyzes the books of 1923 on history and natural history of museum orientation, which are stored in the State Printing Archive of the Book Chamber of Ukraine. In total, 18 books have been identified, which are divided into the following types: scientific (2), popular science (4), popular (1), educational and educational-methodical (8), reference (3). According to the thematic orientation, there are 7 books on history, 5 — on natural science, 3 — on reference, 2 — on museum work, 1 — on book monumentology. The books of G. Levin-Dorsch and G. Kunov, M. Zieber, B. Vipper, M. Yavorsky, A. Winterhalter, M. Levin, B. Komarov, Iv. Trojanovski, O. Nikol'sky, P. Tutkovsky, V. Hnatyuk, F. Schmit are analyzed.
The processed editions make it possible to introduce unknown and little-known publications on museum studies of 1923 into scientific circulation, to reveal the "white spots" in the activities of specialists in museum pedagogy.
Sistem Artificial Intelligence Deteksi Penyakit THT dan Jantung Menggunakan Forward Chaining dan Image Processing
Authors: Wibowo Ari Purno Wahyu , Hamdani Dani , Heryono Heri , Pratama Rizky Fajar 
Published: May 2024

Heart disease and ENT (Ear, Nose and Throat) disease are serious can threaten human health and even life, the attacks of these two diseases can come suddenly without us realizing it, the symptoms are similar to ordinary diseases, the aim of this research is created based on AI (artificial intelligence) which is able to provide a quick response when a disease attacks us by looking for signs of physical changes or early symptoms in the body, examples of these symptoms are changes in skin color or finger nails which can indicate the presence of a serious disease, the method used is a combination of two detection methods using forward chaining and the heart disease detection system using the image processing method, the application created is able to detect disease symptoms and measure the level of accuracy of the detection results, so that the patient or doctor is able to measure the severity of the disease, from the experimental results it can be concluded that this system can recognize with an accuracy of above 80%, this application doesn't replace the doctor as a medical expert but is used for recognize early symptoms and carry out prevention processes disease becomes more serious.
HepG2.2.15-derived exosomes facilitate the activation and fibrosis of hepatic stellate cells
Authors: Gao Yang , Li Li , Zhang Sheng-Ning , Mang Yuan-Yi , Zhang Xi-Bing , Feng Shi-Ming 
Published: May 2024

BACKGROUND
The role of exosomes derived from HepG2.2.15 cells, which express hepatitis B virus (HBV)-related proteins, in triggering the activation of LX2 liver stellate cells and promoting liver fibrosis and cell proliferation remains elusive. The focus was on comprehending the relationship and influence of differentially expressed microRNAs (DE-miRNAs) within these exosomes.
AIM
To elucidate the effect of exosomes derived from HepG2.2.15 cells on the activation of hepatic stellate cell (HSC) LX2 and the progression of liver fibrosis.
METHODS
Exosomes from HepG2.2.15 cells, which express HBV-related proteins, were isolated from parental HepG2 and WRL68 cells. Western blotting was used to confirm the presence of the exosomal marker protein CD9. The activation of HSCs was assessed using oil red staining, whereas DiI staining facilitated the observation of exosomal uptake by LX2 cells. Additionally, we evaluated LX2 cell proliferation and fibrosis marker expression using 5-ethynyl-2′-deoxyuracil staining and western blotting, respectively. DE-miRNAs were analyzed using DESeq2. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways were used to annotate the target genes of DE-miRNAs.
RESULTS
Exosomes from HepG2.2.15 cells were found to induced activation and enhanced proliferation and fibrosis in LX2 cells. A total of 27 miRNAs were differentially expressed in exosomes from HepG2.2.15 cells. GO analysis indicated that these DE-miRNA target genes were associated with cell differentiation, intracellular signal transduction, negative regulation of apoptosis, extracellular exosomes, and RNA binding. KEGG pathway analysis highlighted ubiquitin-mediated proteolysis, the MAPK signaling pathway, viral carcinogenesis, and the toll-like receptor signaling pathway, among others, as enriched in these targets.
CONCLUSION
These findings suggest that exosomes from HepG2.2.15 cells play a substantial role in the activation, proliferation, and fibrosis of LX2 cells and that DE-miRNAs within these exosomes contribute to the underlying mechanisms.
Cell division cyclin 25C knockdown inhibits hepatocellular carcinoma development by inducing endoplasmic reticulum stress
Authors: Li Yan-Fei , Zheng Fang-Yuan , Miao Xin-Yu , Liu Hai-Long , Zhang Yao-Yao , Chao Nai-Xia , Mo Fa-Rong 
Published: May 2024

BACKGROUND
Cell division cyclin 25C (CDC25C ) is a protein that plays a critical role in the cell cycle, specifically in the transition from the G2 phase to the M phase. Recent research has shown that CDC25C could be a potential therapeutic target for cancers, particularly for hepatocellular carcinoma (HCC). However, the specific regulatory mechanisms underlying the role of CDC25C in HCC tumorigenesis and development remain incompletely understood.
AIM
To explore the impact of CDC25C on cell proliferation and apoptosis, as well as its regulatory mechanisms in HCC development.
METHODS
Hepa1-6 and B16 cells were transduced with a lentiviral vector containing shRNA interference sequences (LV-CDC25C shRNA) to knock down CDC25C . Subsequently, a xenograft mouse model was established by subcutaneously injecting transduced Hepa1-6 cells into C57BL/6 mice to assess the effects of CDC25C knockdown on HCC development in vivo . Cell proliferation and migration were evaluated using a Cell Counting Kit-8 cell proliferation assays and wound healing assays, respectively. The expression of endoplasmic reticulum (ER) stress-related molecules (glucose-regulated protein 78, X-box binding protein-1, and C/EBP homologous protein) was measured in both cells and subcutaneous xenografts using quantitative real-time PCR (qRT-PCR) and western blotting. Additionally, apoptosis was investigated using flow cytometry, qRT-PCR, and western blotting.
RESULTS
CDC25C was stably suppressed in Hepa1-6 and B16 cells through LV-CDC25C shRNA transduction. A xenograft model with CDC25C knockdown was successfully established and that downregulation of CDC25C expression significantly inhibited HCC growth in mice. CDC25C knockdown not only inhibited cell proliferation and migration but also significantly increased the ER stress response, ultimately promoting ER stress-induced apoptosis in HCC cells.
CONCLUSION
The regulatory mechanism of CDC25C in HCC development may involve the activation of ER stress and the ER stress-induced apoptosis signaling pathway.
Gold Mineralization, Hydrothermal Alteration, and Li Isotope Fractionation at Cochenour Orogenic Gold Deposit, Red Lake, Canada
Authors: Nadeau Olivier , Gatenby Alex J. , Xiao Yilin 
Published: May 2024

Abstract
Lithium isotopes have been used to study subduction zones, continental weathering, and magmatic–hydrothermal transitions, but little is known about their behavior in metasomatic footprints surrounding hydrothermal ore deposits. Although minerals such as biotite, chlorite, and white micas may sometimes be characteristic of Au mineralization, they are not truly diagnostic given that they also usually occur outside the ore zones. Here, whole rock δ7Li compositions are measured in samples from drill core cutting through metasomatized basalts from the Cochenour orogenic Au deposit, Red Lake, Canada, to verify whether Au ore-related biotite, chlorite, white micas, and quartz have specific δ7Li signatures. Laser ablation ICP-MS maps show 1000–1100 ppm Li in biotite, 200–600 ppm in chlorite, and 20–100 ppm in white mica. In the ‘arsenopyrite-bearing replacement-style’ alteration and mineralization, Au is associated with arsenopyrite, pyrrhotite, and chalcopyrite in the ore zone, but is more concentrated in white mica than in sulfides outside the ore zone. In the cross-cutting ‘quartz-actinolite vein-style’ alteration and mineralization, Au is distributed with chalcopyrite and arsenopyrite in the selvages of the veinlets, but is associated with pyrite, calcite, and biotite outside the ore zone. Mass balance calculations suggest that Au ore-related biotite, chlorite, white mica, and quartz have δ7Li values of ∼+4‰, ∼0 to +2‰, ∼−2‰, and ∼+6 to +12‰, respectively. This is explained by Li isotopic fractionation occurring during the retrograde sequence of auriferous biotite-chlorite-white mica alteration and the late auriferous quartz vein event, identified in the present samples as well as in the Red Lake-Campbell mine complex and the Red Lake greenstone belt. In the ‘arsenopyrite-bearing replacement-style’ alteration, the intercorrelation of δ7Li and Au and their correlation over distance show greater amounts of Au in biotite-enriched rocks, where biotite has δ7Li values of ∼+4‰. Such values indicate a mantle source for the early biotite-related auriferous fluid at Red Lake.
La Metacognición: Estrategia para el Desarrollo de Competencias Académicas
Authors: Molina Lara Luz María 
Published: May 2024

La “aldea global” de conocimiento en la que vive la sociedad contemporánea, demanda de la labor educativa y de sus protagonistas (maestros – educadores) la formación de personas con habilidades cognitivas; capaces de construir conocimientos y resolver situaciones problemas, a través del planteamiento de alternativas lógicas de solución; que propendan por el desarrollo de los saberes y competencias con las que cuenta sus conciudadanos (Llatas, 2016). De esta manera, el presente estudio tiene como finalidad realizar un análisis reflexivo, a partir de la revisión teórica y de antecedentes investigativos, sobre la contribución de la metacognición al desarrollo de la competencia académica a nivel escolar. Los hallazgos permiten dilucidar que desarrollar la cognición humana, implica llevar a cabo estrategias pedagógicas destinadas al desarrollo de habilidades de pensamiento, tal como la metacognición, que se constituye en una herramienta metodológica clave en el proceso de enseñanza – aprendizaje, hacia el fortalecimiento de procesos pedagógicos innovadores y de calidad; que incentivan la cognición y el desarrollo intelectual, de manera que respondan de forma holística al contexto de los educandos.
PENGGUNAAN MODEL PEMBELAJARAN CREATIVE PROBLEM SOLVING TERHADAP KEMAMPUAN BERPIKIR KRITIS SISWA PADA PEMBELAJARAN MATEMATIKA
Authors: Arlingga Illen Fitria , Yuhana Yuyu , Yandari Indhira Asih Vivi 
Published: May 2024

Penelitian ini bertujuan untuk mengetahui bagaimana kemampuan berpikir kritis peserta didik pada pembelajaran matematika melalui penggunaan model pembelajaran Creative Problem Solving (CPS) kelas IV SDN Cikasungka II. Penelitian ini dilatarbelakangi oleh rendahnya kemampuan berpikir kritis peserta didik pada pembelajaran matematika. Jenis penelitian ini adalah penelitian kuantitatif dengan metode penelitian kuasi eksperimen dan desain nonequivalent control group. Sampel dari penelitian ini ialah kelas IV A dan kelas IV B SDN cikasungka II yang berjumalah 55 peserta didik. 28 peserta didik kelas IV A dan 27 peserta didik kelas IV B. Teknik pengumpulan datanya yaitu menggunakan teknik tes dengan melakukan pre-test dan post-test. Teknik analisis datanya menggunakan analisis statistik deskriptif dan analisis statistik inferensial. Hasil penelitian menunjukkan bahwa penggunaan model pembelajaran Creative Problem Solving (CPS) lebih baik daripada sebelum diterapkannya model pembelajaran Creative Problem Solving (CPS). Hal ini ditunjukkan berdasarkan hasil akhir perhitungan dan data yang diperoleh dengan menggunakan uji t yaitu thitung = 0,24 dan ttabel = 1,67. Dikarenakan thitung lebih kecil dari ttabel, maka Ho diterima dan Ha ditolak, sehingga mendapatkan kesimpulan bahwa Kemampuan berpikir kritis peserta didik yang menggunakan model pembelajaran Creative Problem Solving (CPS) lebih baik daripada kemampuan berpikir kritis peserta didik yang menggunakan model pembelajaran langsung (Direct Instruction).