bluuebunny/crossref_metadata_2025_split huggingface dataset:
Diagnosis and Treatment of Gastroenteropancreatic Neuroendocrine Tumors: Current Data on a Prospectively Collected, Retrospectively Analyzed Clinical Multicenter Investigation
Authors: Niederle Martin B. , Niederle Bruno 
Published: April 2011

Abstract

Background.
The aim of this prospectively collected, retrospectively analyzed clinical investigation was to describe “unmasked” clinical symptoms and methods of diagnosis, treatment, and short-term follow-up of gastroenteropancreatic neuroendocrine tumors (GEP-NETs) diagnosed during 1 year in Austria.

Methods.
In total, 277 patients with GEP-NETs were documented. All tumors were immunhistochemically defined according to recently summarized criteria (World Health Organization, European Neuroendocrine Tumour Society). A standardized questionnaire comprising 50 clinical and biochemical parameters (clinical symptoms, mode of diagnosis, treatment, follow-up) was completed by attending physicians.

Results.
The most common initial symptoms were episodes of abdominal pain, diarrhea, weight loss, gastrointestinal bleeding, flushing, and bowel obstruction. Overall, 48.1% of tumors were diagnosed by endoscopy, 43.7% were diagnosed during surgery, 5% were diagnosed by fine-needle aspiration of the primary or metastases, and 2.5% were diagnosed during autopsy; 44.5% of tumors were not suspected clinically and were diagnosed incidentally during various surgical procedures. Overall, 18.7% of tumors were removed endoscopically and 67.6% were removed surgically; 13.7% of patients were followed without interventional treatment. Endoscopic or surgical intervention was curative in 81.4% of patients and palliative in 18.6% of patients. At the time of diagnosis, information on metastasis was available in 83.7% of patients with malignant NETs. Lymph node or distant metastases were documented in 74.7% of patients. In 19.3% of patients, 41 secondary tumors were documented, with 78.0% classified histologically as adenocarcinomas.

Conclusion.
This investigation summarizes the clinical presentation and current practice of management of GEP-NETs and thereby extends the understanding and clinical experience.
Relationships Between Eating Habits and Periodontal Condition in University Students
Authors: Tomofuji Takaaki , Furuta Michiko , Ekuni Daisuke , Irie Koichiro , Azuma Tetsuji , Iwasaki Yoshiaki , Morita Manabu 
Published: April 2011

Background: Being overweight is a risk factor for periodontitis. Unhealthy eating habits, which can induce overweight, may be involved in the development of periodontitis in young people. The present study aims to examine the relationships among overweight, eating habits, and the periodontal condition in Japanese university students.Methods: We conducted a cross‐sectional study of 801 university students (413 males and 388 females; age range: 18 to 25 years). Patients were classified as underweight (body mass index [BMI] <18.5 kg/m2), normal weight (BMI of 18.5 to 22.9 kg/m2), and overweight (BMI ≥23 kg/m2). Students completed a questionnaire including items related to eating habits and underwent oral health examinations. Patients with a community periodontal index (CPI) of 0 to 2 were considered controls, and patients with a CPI >2 were considered to have periodontitis.Results: The prevalence of underweight, normal weight, and overweight patients was 21%, 62%, and 17%, respectively. In overweight patients, the periodontitis risk was increased by the frequent consumption of fatty foods (adjusted odds ratio: 2.3; 95% confidence interval: 1.1 to 5.2; P <0.05) and reduced by the frequent consumption of vegetables (adjusted odds ratio: 0.2; 95% confidence interval: 0.1 to 0.7; P <0.01). In underweight and normal‐weight groups, eating habits did not differ significantly according to the presence of periodontitis.Conclusions: In overweight students, the frequent consumption of fatty foods and infrequent consumption of vegetables were associated with an increased risk of periodontitis. In underweight and normal‐weight students, eating habits had little effect on the periodontal condition.
Radar monitoring of seasonal bird migration over central Israel
Authors: Dinevich Leonid , Leshem Yossi 
Published: April 2011

Radar monitoring of seasonal bird migration over central Israel
A radar ornithological station has been created based on the meteorological radar MRL-5 and a specially designed algorithm. The system enables to plot radar charts within the radius of 60 km combining meteorological data with vectors of bird field flying at different heights and pass these charts online over to air traffic control operators. The data accumulated in the study made it possible to obtain certain characteristics of seasonal bird migration over central Israel. The system and the results of the study have become an integral part of ensuring air safety for Israeli military aircraft. The paper is an overview and summary of a development of the system, which was described in a few earlier publications.
Integrated high-resolution stratigraphy of a Middle to Late Miocene sedimentary sequence in the central part of the Vienna Basin
Authors: Paulissen Wieske , Luthi Stefan , Grunert Patrick , Ćorić Stjepan , Harzhauser Mathias 
Published: April 2011

Integrated high-resolution stratigraphy of a Middle to Late Miocene sedimentary sequence in the central part of the Vienna BasinIn order to determine the relative contributions of tectonics and eustasy to the sedimentary infill of the Vienna Basin a high-resolution stratigraphic record of a Middle to Late Miocene sedimentary sequence was established for a well (Spannberg-21) in the central part of the Vienna Basin. The well is located on an intrabasinal high, the Spannberg Ridge, a location that is relatively protected from local depocentre shifts. Downhole magnetostratigraphic measurements and biostratigraphical analysis form the basis for the chronostratigraphic framework. Temporal gaps in the sedimentary sequence were quantified from seismic data, well correlations and high-resolution electrical borehole images. Stratigraphic control with this integrated approach was good in the Sarmatian and Pannonian, but difficult in the Badenian. The resulting sedimentation rates show an increase towards the Upper Sarmatian from 0.43 m/kyr to > 1.2 m/kyr, followed by a decrease to relatively constant values around 0.3 m/kyr in the Pannonian. The sequence reflects the creation of accommodation space during the pull-apart phase of the basin and the subsequent slowing of the tectonic activity. The retreat of the Paratethys from the North Alpine Foreland Basin during the Early Sarmatian temporarily increased the influx of coarsergrained sediment, but eventually the basin acted mostly as a by-pass zone of sediment towards the Pannonian Basin. At a finer scale, the sequence exhibits correlations with global eustasy indicators, notably during the Sarmatian, the time of greatest basin subsidence and full connectivity with the Paratethyan system. In the Pannonian the eustatic signals become weaker due to an increased isolation of the Vienna Basin from Lake Pannon.
The Immediate Effects of Muscle Energy Technique on Posterior Shoulder Tightness: A Randomized Controlled Trial
Authors: Moore Stephanie D. , Laudner Kevin G. , Mcloda Todd A. , Shaffer Michael A. 
Published: April 2011

Study Design Randomized controlled trial. Objective To compare a muscle energy technique (MET) for the glenohumeral joint (GHJ) horizontal abductors and an MET for the GHJ external rotators to improve GHJ range of motion (ROM) in baseball players. Background Overhead athletes often exhibit loss of GHJ ROM in internal rotation, which has been associated with shoulder pathology. Current stretching protocols aimed at improving flexibility of the posterior shoulder have resulted in inconsistent outcomes. Although utilization of MET has been hypothesized to lengthen tissue, there are limited empirical data describing the effectiveness of such stretches for treating posterior shoulder tightness. Methods Sixty-one Division I baseball players were randomly assigned to 1 of 3 groups: MET for the GHJ horizontal abductors (n = 19), MET for the GHJ external rotators (n = 22), and control (n = 20). We measured preintervention and postintervention GHJ horizontal adduction and internal rotation ROM, and conducted analyses of covariance, followed by Tukey honestly significant difference post hoc analysis for significant group-by-time interactions (P<.05). Results The group treated with the MET for the horizontal abductors had a significantly greater increase in GHJ horizontal adduction ROM postintervention (mean ± SD, 6.8° ± 10.5°) compared to the control group (−1.1° ± 6.8°) (P = .011) and a greater increase in internal rotation ROM postintervention (4.2° ± 5.3°) compared to the group treated with the MET for the external rotators (0.2° ± 6.3°) (P = .020) and the control group (−0.2° ± 4.0°) (P = .029). No significant differences among groups were found for any other variables (P>.05). Conclusion A single application of an MET for the GHJ horizontal abductors provides immediate improvements in both GHJ horizontal adduction and internal rotation ROM in asymptomatic collegiate baseball players. Application of MET for the horizontal abductors may be useful to gain ROM in overhead athletes. Level Of Evidence Therapy, level 2b-. J Orthop Sports Phys Ther 2011;41(6):400–407, Epub 6 April 2011. doi:10.2519/jospt.2011.3292
Diagnostic Perils in Jaw Pain
Authors: Krishna Sowmya , Badam Rajkumar , Sobti Geetika 
Published: April 2011

ABSTRACTChronic pain in the orofacial region is a common complaint faced by clinicians. It is important for the dentists to have a thorough knowledge of various causes of jaw pain. Most common type reported is toothache. Since toothache is so common, it is important to determine if pain is from odontogenic or nonodontogenic origin. The need for careful diagnosis before undertaking any invasive treatment is the key to prevent misdiagnosis and mismanagement in patients with chronic orofacial pain. Emphasis in this article is on the differential diagnosis of jaw pain originating from muscular, neuropathic, cardiac, sinus and psychogenic origin.
Treatment of Osteonecrosis of the Femoral Head with Core Decompression and Bone Grafting
Authors: Wei Biao Fang , Ge Xiang Hua 
Published: April 2011

Osteonecrosis of the femoral head (ONFH) is a disorder that can lead to femoral head collapse. Various procedures have been advocated to avert the need for total hip replacement. These include vascularised and non-vascularised bone grafting procedures. We examined the effect of core decompression combined with an allogeneic, antigen-extracted, autolysed fibular allograft and autologous impacted bone grafting for the treatment of osteonecrosis of the femoral head. The study included 162 patients (223 hips; 61 females, 101 males; mean age 33.5 years, range 19–54 years) with stage II–III avascular necrosis of the femoral head according to the ARCO (Association Research Circulation Osseous) classification. The outcome was determined by changes in the Harris hip score, by progression in radiographic stages, and by the need for hip replacement. The mean follow-up was 24 months (range 7–42 months). Statistical evaluation included Kaplan-Meier survival analysis. The mean Harris hip score increased from 61 to 85. Excellent and good results were obtained in 93.3% of cases in stage II, and 87% in stages III with a survivorship of 81% in all cases. Core decompression combined with an allogeneic, antigen-extracted, autolysed fibular allograft and autologous impacted bone grafting may be the treatment of choice, particularly in the precollapse stage.
A Prospective Randomised Study of Periprosthetic Femoral Bone Remodeling Using Four Different Bearings in Hybrid Total Hip Arthroplasty
Authors: Zerahn Bo , Borgwardt Lotte , Ribel-Madsen Søren , Borgwardt Arne 
Published: April 2011

We performed a study to assess whether different bearing materials have an impact on femoral bone remodeling within the first four years after a hybrid total hip arthroplasty. 205 of 300 patients were available for 4 years follow-up after being randomly allocated to four prosthetic combinations: A: Zirconia ceramic head, polyethylene cup; B: Cobalt-Chrome-Molybdenum head and cup; C: Zirconia ceramic head, polyethylene moulded on the Titanium shell of the Asian cup; D: Alumina head and cup. Bone mineral density (BMD) was measured with Dual-Energy X-ray Absorptiometry in seven Gruen zones adjacent to the femoral implant. Scans were performed within one week after surgery and four years postoperatively. Clinical outcomes were monitored using the Oxford Hip Score (OHS). A high proportion of patients from group D were excluded due to re-operations (19 patients). BMD decreased significantly in all Gruen zones with the largest declines in group D. BMD changes in Gruen zones 1, 2, 3, 6, and 7 correlated with height, and body weight. Advanced age was associated with an increase in bone loss in Gruen zones 1, 2, 3, 6, and 7. A large stem size was associated with a decline in BMD in Gruen zones 1, 6, and 7. Bone remodeling after total hip arthroplasty may depend on the composition of bearing materials, but age, height, weight, and stem size are also related to changes in BMD.
Das Projekt NaWi‐aktiv
Authors: Höffler Tim N. , Lüthjohann Frank , Bertelsen Gesine , Demuth Reinhard , Parchmann Ilka 
Published: April 2011

AbstractLeistungsschwächere Kinder der fünften und sechsten Jahrgangsstufe mit ihren oft unentdeckten und wenig geförderten Talenten sind die Zielgruppe des Projektes NaWi‐aktiv. Eine Förderung naturwissenschaftlicher Kompetenzen und Interessen wird mit der Weiterentwicklung anderer Fähigkeiten und des allgemeinen Selbstkonzepts der Kinder verbunden. Dieser Beitrag stellt das an fünf Pilotschulen in Schleswig‐Holstein realisierte Projekt mit seiner Kombination aus wöchentlicher Naturwissenschafts‐Arbeitsgemeinschaft und einwöchigen „Forschercamps“ vor und berichtet von ersten Ergebnissen der Evaluation.
Small cell variant of malignant melanoma masquerading as lymphoma on fine‐needle aspiration cytology: A case report
Authors: Buehler Darya , Waknitz Michelle , Rehrauer William , Ranheim Erik , Selvaggi Suzanne 
Published: April 2011

AbstractThe morphologic and immunohistochemical diversity of malignant melanoma is well known to pathologists but despite this widespread awareness the diagnosis remains a constant challenge, particularly when a noncutaneous or metastatic tumor is evaluated by fine‐needle aspiration cytology. We present a case of the small cell variant of malignant melanoma mimicking lymphoma in a 78‐year‐old previously healthy male who presented with multiple pulmonary masses and a right‐sided pleural effusion. This particular case was also immunoreactive for the hematopoietic marker CD43, a feature not previously reported in malignant melanoma. Cytologic, histologic, and immunohistochemical features of this case are presented and discussed. Diagn. Cytopathol. 2012. © 2011 Wiley Periodicals, Inc.
Maxillary cementifying fibroma: A case report with fine‐needle aspiration cytology highlighting the expanding role of e‐medicine in cytopathologist collaborations
Authors: Sivasubramaniam Vanathi , Faduyile Francis , Zarka Matthew A. , Deery Alastair , Field Andrew 
Published: April 2011

AbstractCementifying fibroma is an uncommon fibro‐osseous lesion presenting in the oral cavity, which may present in children as an aggressive juvenile subtype of either psammomatoid or trabecular variant. Appropriate management, to achieve local control and prevent destructive expansion, requires early diagnosis, which fine‐needle aspiration cytology (FNAC) can provide rapidly in a minimally invasive manner. The role of FNAC is even more powerful in situations where medical facilities are limited or where surgical biopsy is contraindicated. We report a case of a 6‐year‐old boy from Lagos, Nigeria, whose initial diagnosis of cementifying fibroma was made on photographed digital images in jpeg format of FNAC slides, which were then emailed as attachments to Sydney, Australia and to Scottsdale, USA. The tumor was subsequently confirmed as a juvenile trabecular variant of cementifying fibroma on histopathology on a surgical excision in London, United Kingdom. The ability to electronically send cytopathology images around the world for a definitive second opinion is a practical example of the power of e‐medicine to achieve an accurate FNAC diagnosis. Diagn. Cytopathol. 2012. © 2011 Wiley Periodicals, Inc.
TGF‐β limits IL‐33 production and promotes the resolution of colitis through regulation of macrophage function
Authors: Rani Reena , Smulian Alan G. , Greaves David R. , Hogan Simon P. , Herbert De'Broski R. 
Published: April 2011

AbstractMϕs promote tissue injury or repair depending on their activation status and the local cytokine milieu. It remains unclear whether the immunosuppressive effects of transforming growth factor β (TGF‐β) serve a nonredundant role in Mϕ function in vivo. We generated Mϕ‐specific transgenic mice that express a truncated TGF‐β receptor II under control of the CD68 promoter (CD68TGF‐βDNRII) and subjected these mice to the dextran sodium sulfate (DSS) model of colitis. CD68TGF‐βDNRII mice have an impaired ability to resolve colitic inflammation as demonstrated by increased lethality, granulocytic inflammation, and delayed goblet cell regeneration compared with transgene negative littermates. CD68TGF‐βDNRII mice produce significantly less IL‐10, but have increased levels of IgE and numbers of IL‐33+ Mϕs than controls. These data are consistent with associations between ulcerative colitis and increased IL‐33 production in humans and suggest that TGF‐β may promote the suppression of intestinal inflammation, at least in part, through direct effects on Mϕ function.
Th17 differentiation is the default program for DPP2‐deficient T‐cell differentiation
Authors: Mele Deanna A. , Sampson James F. , Huber Brigitte T. 
Published: April 2011

AbstractDipeptidyl peptidase 2 (DPP2) is an N‐terminal dipeptidase, required for maintaining lymphocytes in a resting state. Mutant mice with T‐cell‐specific knock‐down (kd) of DPP2 (lck‐DPP2 kd) were generated and analyzed for their phenotype. Normal thymocyte development and a modest increase in the proportions of peripheral T cells were observed in these mice compared with littermate controls. Interestingly, the peripheral T cells were hyperactive upon TCR stimulation in vitro, although they did not express any activation markers. Furthermore, CD3‐crosslinking in the naïve CD4+ and CD8+ T cells of lck‐DPP2 kd mice resulted mainly in IL‐17 production. Similarly, the mutant T cells secreted primarily IL‐17 after in vivo priming and in vitro antigen‐specific restimulation. These data suggest that IL‐17 production is the default program for T‐cell differentiation in the absence of DPP2. Thus, DPP2 seems to impose a threshold for quiescent T cells, preventing them from drifting into cell cycle.
Rigid Luminescent Bis‐Zinc(II)–Bis‐Cyclen Complexes for the Detection of Phosphate Anions and Non‐Covalent Protein Labeling in Aqueous Solution
Authors: Bhuyan Mouchumi , Katayev Evgeny , Stadlbauer Stefan , Nonaka Hiroshi , Ojida Akio , Hamachi Itaru , König Burkhard 
Published: April 2011

AbstractA series of water‐soluble bis‐ and tetrakis‐ZnII–cyclen complexes with rigid structures was prepared to enhance the carboxylate and phosphate ion binding response in contrast to analogues with less‐confined molecular structures. Boc‐protected 6‐chloro‐1,3,5‐triazine–bis‐cyclen was coupled to different aryl and alkyl moieties in moderate to high yields and subsequently converted into the corresponding bis‐ or tetrakis‐ZnII–cyclen complexes. The bis‐ZnII–cyclen moiety is known for its affinity to anions. Depending on the arene substituent some of the synthesized synthetic receptors are luminescent. They were studied by absorption and emission spectroscopy for their response to the presence of phosphate anions of biological relevance in buffered aqueous solution at neutral pH and for their affinity to the genetically encodable oligoaspartate and glutamate sequences (D4 and E4 tag) recently introduced. The rigid structures of the compounds enhance the electronic coupling between the metal complex binding site and the reporter dye. This leads to an increased anion binding response in homogeneous aqueous solution.
Psychological resilience in young and older adults
Authors: Gooding P. A. , Hurst A. , Johnson J. , Tarrier N. 
Published: April 2011

BackgroundThe goal of the current study was to investigate psychological resilience in the older adults (>64 years) compared with that of the young ones (<26 years).MethodsQuestionnaire measures of depression, hopelessness, general health and resilience were administered to the participants. The resilience measure comprised three sub‐scales of social support, emotional regulation and problem solving.ResultsThe older adults were the more resilient group especially with respect to emotional regulation ability and problem solving. The young ones had more resilience related to social support. Poor perceptions of general health and low energy levels predicted low levels of resilience regardless of age. Low hopelessness scores also predicted greater resilience in both groups. Experiencing higher levels of mental illness and physical dysfunction predicted high resilience scores especially for the social support resilience scale in the older adults. The negative effects of depression on resilience related to emotional regulation were countered by low hopelessness but only in the young adults.ConclusionsThese results highlight the importance of maintaining resilience‐related coping skills in both young and older adults but indicate that different psychological processes underlie resilience across the lifespan. Copyright © 2011 John Wiley & Sons, Ltd.
Excitation profiles of resonant coherent Raman scattering by impurity molecules
Authors: Tehver Imbi , Kaasik Helle , Hizhnyakov Vladimir 
Published: April 2011

AbstractThe amplitudes and the excitation profiles of coherent resonant Raman scattering (coherent anti‐Stokes and Stokes Raman scattering (CARS and CSRS)) by impurity centers in crystals and/or molecules in solutions are studied, taking into account the coherence of the excited mode and the inhomogeneity of the environment. The CARS and CSRS excitation profiles can directly be related to one‐photon absorption when using the transform theory known from spontaneous resonant Raman scattering. The enlargement of the amplitude of the active mode reveals itself in an enhancement of the vibrational overtones. At large amplitudes, a splitting in the profiles caused by the contribution of two turning points of a strong coherent vibration is observed. The inhomogeneous broadening is different in the excitation profiles of CARS and CSRS. The overlapping contributions to spectrally narrow and broad transitions lead to Fano peculiarities. The effects are illustrated by model calculations. Copyright © 2011 John Wiley & Sons, Ltd.