bluuebunny/crossref_metadata_2025_split huggingface dataset:
Utilisation Trends of Lisdexamfetamine: Insights From Recent Medicine Shortages in Australia
Authors: Janetzki Jack , Kalisch Lisa , Hall Kelly , Pratt Nicole 
Published: February 2025

ABSTRACTPurposeInvestigate the impact of recent notified medicine shortages on dispensing patterns of 30, 40, 50, and 60 mg strengths of lisdexamfetamine for treatment of Attention Deficit Hyperactivity Disorder (ADHD) in Australia.MethodsPharmaceutical Benefits Scheme (PBS) aggregate dispensing data for 2022–2024 were analysed. Monthly dispensings and Defined Daily Doses (DDDs) for lisdexamfetamine were calculated overall and by product strength.ResultsFrom January 2022 to August 2023, there was a constant increase in overall dispensing and volume of lisdexamfetamine likely due to expansion of PBS prescribing restrictions allowing subsidy of this medicine for patients 18 years and older in February 2021. Dispensings of the 30 mg strength decreased from August 2023 corresponding with shortages of this product. Dispensings of the 50 mg peaked in October 2023 then decreased. During the shortage of the 30 and 50 mg strengths, dispensings of the 40 and 60 mg strengths increased, however, by December 2023 dispensings of these strengths were also decreasing. Dispensings of 70 mg strengths grew steadily throughout 2024. DDDs changed substantially during the shortage period suggesting that people likely transitioned to different strengths of lisdexamfetamine to maintain their dose.ConclusionDispensing patterns of lisdexamfetamine, by strength, changed significantly during the medicines shortages periods revealing potential changes in prescriber and patient behaviours, such as switching to higher strength products or using medicines intermittently, to maintain continuity of care. To facilitate quality use of medicines during shortages, dispensing patterns must be monitored so that inequities of access can be identified and addressed.
A new generation of green rubber plasticizer: Study on the application of liquid polybutadiene rubber in green radial tread rubber
Authors: Zhao Guangxin , Yong Zhanfu 
Published: February 2025

AbstractLiquid rubber, an environmentally friendly oligomer with low viscosity, exhibits the capability of co‐crosslinking within the rubber matrix. In this paper, liquid butadiene rubber (LPBD) is employed to replace the plasticizer‐treated distillate aromatic extract (TDAE) in the green tread rubber. The results demonstrate the superior performance of LPBD compared to TDAE, particularly in terms of tensile strength at both high and room temperature, elongation at break, and rebound properties. Although the increase in DIN abrasion volume and loss factor at 60°C is relatively smaller, and the hardness is reduced in the case of equal replacement of TDAE, these performance improvements can be achieved by adjusting the crosslink density to achieve comparable results with TDAE plasticizer usage. In summary, LPBD can replace TDAE, reduce rolling resistance, and improve wet skid resistance, offering a promising solution to the long‐standing issue of plasticizer pollution in the rubber industry.Highlights
Feasibility of using LPBD instead of TDAE as a plasticizer in the green tread rubber.
Crosslinking of LPBD and rubber matrix improves mechanical properties at high temperature.
Adjustment of crosslinked network improves wet skid resistance and rolling resistance.
DPP‐IV Inhibitory Peptides From Whey Proteins: Production, Functional Mechanisms, Bibliometric Insights, and Future Directions for Type 2 Diabetes Therapy
Authors: García‐Curiel Laura , Berenice Olvera‐Rosales Laura , Elizabeth Cruz‐Guerrero Alma , Emmanuel Pérez‐Escalante , Pérez‐Flores Jesús Guadalupe , Guillermo González‐Olivares Luis 
Published: February 2025

ABSTRACTThis study addressed the therapeutic potential of dipeptidyl peptidase IV (DPP‐IV) inhibitory peptides obtained by whey protein hydrolysis as natural adjuvants to synthetic drugs for managing type 2 diabetes (T2D), a condition marked by insulin resistance and hyperglycemia. Given the rising global incidence of T2D, exploring such bioactive compounds is important for developing effective and sustainable treatment strategies. The research highlights the role of DPP‐IV inhibitors in promoting insulin secretion by preventing the degradation of incretin hormones, with whey‐derived peptides emerging as promising natural candidates for DPP‐IV inhibition. A bibliometric analysis revealed a steady growth in publication output since 2006, with significant contributions from China, France, and the USA, underscoring this field's global and interdisciplinary nature, which spans food science, physiology, and nutrition. The VOSviewer analysis identified key research clusters, including “Health Benefits and Biological Effects of Dairy Proteins,” “T2D/drug therapy,” and emerging areas like “insulin/metabolism” and “diet,” reflecting a growing interest in these topics. The findings emphasize the expanding focus on functional foods and bioactive compounds in chronic disease management, highlighting the necessity for further research to fully elucidate the impact of these peptides on T2D and their potential role in global health initiatives, emphasizing the importance of integrating bioactive compounds into functional foods to support long‐term health outcomes and the need for clinical trials to validate the efficacy further.
Validation of Thermal Models for Bifacial Photovoltaic Systems Under Various Albedo Conditions
Authors: Kirsten Vidal de Oliveira Aline , Braga Marília , Naspolini Helena Flávia , Rüther Ricardo 
Published: February 2025

ABSTRACTThis study evaluates the performance of three photovoltaic (PV) module operating temperature models—Ross, Faiman, and PVsyst®—using various measurement time resolutions for bifacial PV systems under various albedo conditions. This work also includes the application of these models using effective irradiance – incorporating both front and rear‐side plane of array irradiance – for the estimation of bifacial PV module temperature. The calculated heat transfer coefficients for each evaluated scenario are presented and discussed in detail. A comprehensive comparison of all simulated scenarios was carried out to recommend the most suitable model for each condition. Additionally, the use of estimated cell operating temperature from back‐of‐module temperature was evaluated across all scenarios. As expected, hourly resolutions provided better results for all scenarios, having the lowest error for temperature estimations across different models and ground (albedo) types. Accounting for rear‐side irradiance and using calculated coefficients led to more accurate temperature predictions, emphasizing the importance of model adaptations and precise parameterization. The results for different heat transfer coefficients varied significantly among the models. Ross's model, when applied with standard values (k between 0.02 and 0.04) showed close alignment with measured data. In contrast, Faiman's model with standard coefficients ( between 24 and 27 W/m2·°C, between 6 and 8 W/m2·°C/m/s) and PVsyst's standard coefficients ( = 29 W/m2·°C,  = 0 W/m2·°C/m/s) exhibited significant deviations. Adjusted coefficients for PVsyst® ( = 40 W/m2·°C,  = 0 W/m2·°C/m/s) provided better accuracy. The standard PVsyst® coefficients presented better results when compared against cell‐adjusted temperature estimates, rather than back‐of‐module measured values. This discrepancy can lead to significant estimation errors in both temperature output performance and for bifacial modules.
Key Considerations on CITE‐Seq for Single‐Cell Multiomics
Authors: Song Hye‐Wong , Martin Jody , Shi Xiaoshan , Tyznik Aaron J. 
Published: February 2025

ABSTRACTCITE‐Seq (Cellular Indexing of Transcriptomes and Epitopes by Sequencing) is an advanced single‐cell sequencing method to profile both gene expression and protein abundance simultaneously in individual cells using single‐cell mRNA sequencing techniques alongside antibody‐derived tags (ADTs), for protein detection. The characterization of both the transcriptome and the proteome from the same cells provides a powerful and multiomic approach for understanding the mechanisms of complex biological processes. This review focuses on the workflow of CITE‐Seq using a microwell‐based single‐cell analysis system as an example and provides key considerations for staining cells with ADTs. By highlighting critical information for CITE‐Seq library preparation, sequencing, and data analysis, this review provides a practical guide with which to perform comprehensive CITE‐Seq workflow.
Smart pH‐Sensitive Biopolymeric Nanocarrier Enables Controlled Release of Curcumin Through Biomimetic Biological Barriers
Authors: Fonseca Gislaine G. , Vieira Edileuza M. , Pereira Marcos V. S. , Andrade Tatianny de A. , Santos Anamaria M. , Gonçalves Amanda P. , Sarafini Mairim R. , Santos Anésia A. , de Figueiredo Eduardo Costa , de Jesus Jemmyson R. 
Published: February 2025

ABSTRACTHerein, the successful synthesis of a chitosan‐iron nanosphere‐based nanocarrier for smart delivery of curcumin (Cur) after penetration of the biomimetic barrier is reported. The synthesized nanocarrier displayed a spherical shape with an average size of 11 nm and a zeta potential value of −30.7 mV. The drug loading efficiency reached 64% ± 4% (n = 3). Infrared analysis confirmed the functionalization of the nanocarrier with Cur. Thermogravimetric analysis (TGA) demonstrated the nanocarrier's stability. The biopolymeric nanospheres exhibited a PCZ at pH 8.22. pH‐responsive study indicated Cur satisfactory release (> 80%) at pH = 7.4. Cur release kinetics followed a pseudo‐second order model (R2 = 0.933), indicating a controlled release behavior. In vitro permeation studies revealed that the polymeric nanocarrier successfully penetrated the biomimetic barrier and delivered Cur to the receptor compartment. Cytotoxicity studies using VERO cells and Artemia salina demonstrated that the nanocarrier exhibits low toxicity. Fluorescence microscopy images suggest that the nanocarrier has cytocompatibility with VERO cells, maintaining cell viability. However, hemolysis was observed at concentrations higher than 54 μmol L−1 in the hemolytic activity study. Finally, through albumin fluorescence suppression analysis, it was observed that the nanocarrier exhibited significant interaction with albumin, indicating its potential for transport through the circulatory system when administered intravenously.
Trajectories of Supportive Care Needs for People Who Travel to Receive Cancer Treatment: A Longitudinal Study in Australia
Authors: Ayre Susannah K. , Johnston Elizabeth A. , Ireland Michael , March Sonja , Dunn Jeff , Chambers Suzanne , Goodwin Belinda C. 
Published: February 2025

ABSTRACTObjectiveTo describe trajectories of change in unmet supportive care needs over a two‐year period among people diagnosed with cancer and assess whether these trajectories vary as a function of sociodemographic and clinical characteristics.MethodsThis analysis used data from a longitudinal study of people in Queensland, Australia who travelled largely from regional and remote areas to metropolitan centres to receive cancer care (N = 784). Supportive care needs were measured at baseline, then at 3‐, 12‐, and 24‐month post‐baseline across five domains (‘psychological’, ‘physical and daily living’, ‘health systems and information’, ‘patient care and support’, ‘sexuality’) using the Supportive Care Needs Survey‐Short Form. Latent Curve Growth Analysis was performed to examine trajectories of change in unmet needs and assess whether these trajectories were influenced by participant characteristics.ResultsSignificant linear slopes indicated a modest decrease in unmet supportive care needs for all domains, except sexuality. For most domains, significant variance in intercepts but not slopes indicated individual differences in needs at baseline but not in trajectories over time. At baseline, the proportion of unmet needs was highest for the ‘physical and daily living’ (M = 44.2%, SD = 39.1%) and ‘psychological’ domains (M = 37.8%, SD = 36.3%). Unmet needs at baseline were consistently higher among participants who were younger, had a higher education level, and who reported poorer QoL.ConclusionsThe proportion of unmet supportive care needs reported by people living with cancer may decrease over time, largely irrespective of sociodemographic and clinical characteristics. Despite this, unmet needs remain prevalent, particularly for physical and psychological support.
Frailty and Sleep in Adult Survivors of Childhood Cancer: A Childhood Cancer Survivor Study Report
Authors: Daniel Lauren C. , Lubas Margaret M. , Wang Huiqi , Szklo‐Coxe Mariana , Ness Kirsten K. , Williams AnnaLynn M. , Mulrooney Daniel A. , Howell Rebecca , Leisenring Wendy , Yasui Yutaka , Robison Leslie L. , Armstrong Gregory T. , Chow Eric J. , Krull Kevin R. , Brinkman Tara M. 
Published: February 2025

ABSTRACTBackgroundYoung adult survivors of childhood cancer exhibit rates of frailty similar to adults several decades older without a cancer history. Frailty has been associated with sleep disturbances in non‐cancer populations, but the relationship has not been examined in childhood cancer survivors who are known to exhibit elevated rates of sleep problems.AimsExamine associations between frailty and poor sleep quality in long‐term survivors of childhood cancer.MethodsThis study utilized data from 9044 participants (> 5 years from diagnosis, Mage = 40.8 years [SD = 9.5]) in the Childhood Cancer Survivor Study. Survivors' frailty status, chronic health conditions (CHC), health behaviors, mental health, and pain were collected in 2014–2016, and self‐reported sleep quality in 2017–2019. Multivariable logistic regression models examined frailty status as a predictor of clinically significant poor sleep. All models were adjusted for age at diagnosis, age at survey, sex, race/ethnicity, smoking, risky/heavy alcohol use, and physical inactivity. Separate models included treatment‐related variables, CHC burden (number/severity), and emotional health/pain as co‐variates.ResultsFrail survivors had 6‐fold (95% CI 4.48–7.96) increased odds of future poor sleep quality. Little attenuation of this association was observed when accounting for cancer diagnosis (Odds Ratio [OR] 5.80, 95% CI 4.47–7.52), treatment exposures (OR 5.80, 95% CI 4.43–7.71), or chronic health condition burden (OR 5.12, 95% CI 3.98–6.59), but adjustment for emotional health/pain (OR 2.88, 95% CI 2.18–3.82) attenuated the association appreciably.ConclusionsFrail childhood cancer survivors have a higher prevalence of clinically significant poor sleep quality. Addressing poor physiologic reserve may impact sleep in frail childhood cancer survivors.
The Botanical University Challenge: Bridging isolation and empowering plant‐aware students
Authors: Hall Hannah , Stroud Sebastian , Culham Alastair , Clubbe Colin , Batke Sven , Medcalf Susan , Jones Meriel G. , Baker Lauren , Lydon Susannah , McGale Erica , Acedo Carmen , Charmley Jonathan , Warren John M. , Mitchley Jonathan 
Published: February 2025

Societal Impact StatementIn some indigenous languages, plants are referred to as ‘those who care for us’, reflecting their essential role in tackling global challenges. Yet, urbanisation and other factors have reduced engagement with plants and botany, decreasing awareness, especially among students. To combat this, three botanists launched the Botanical University Challenge (BUC) to inspire plant‐aware students in the United Kingdom and Ireland. We show how, through competition, BUC fosters a community of budding botanists, equips students with skills to tackle environmental issues and bridges fragmented interest in plants. Its success has sparked similar contests internationally, showcasing BUC's broad appeal and potential to elevate botany globally.SummaryThe Botanical University Challenge (BUC) competition was first devised by three academic botanists in 2015 to champion plants and plant‐aware students and to help connect disparate and disconnected student botanists across the United Kingdom and Ireland. Since then, BUC has grown in popularity to become the largest annual botanical contest in Europe (and possibly the world) with teams competing from a total of 33 higher education institutions from the United Kingdom and the Republic of Ireland answering questions on the full breadth of the botanical sciences. Through running the competition and (since 2023) an associated Student Botany Festival, the BUC Planning Team has had the opportunity to engage with a diverse cohort of plant‐aware students, from undergraduate to doctoral level, enabling them to share their values, passions and concerns for the future. We discuss the development of BUC and our ambitions concerning the future growth and impact of the BUC competition and the ways in which BUC has supported plant‐aware students, such as skills training and career pathway development. We also present two international case studies where the BUC format has been used to facilitate student education and engagement in other countries. We envision BUC as a vehicle to enable connections between plant‐aware students, not only nationally within the United Kingdom but internationally, by encouraging and supporting other communities in similar endeavours.
Fluorescein Derivative Monomer for the Production of Fluorescent Latex Particles
Authors: Femia Anabela L. , Gugliotta Luis M. , Gonzalez Verónica D. G. 
Published: February 2025

AbstractThe use of fluorescent latex particles (FLP) as a tool for microscopy imaging or flux cytometry is an excellent choice for diagnosis, research, and development. They are suitable for complex formation with several biological molecules and macromolecules. A simple and cost‐effective method is here proposed to produce FLP. To this effect, the synthesis of a fluorescent monomer, capable of being copolymerized with vinyl monomers, is achieved by a reaction between fluorescein and glycidyl methacrylate, and monitored by UV–vis, IR, NMR, and Fluorescence spectrometry. The synthesis of fluorescent particles is carried out by emulsion copolymerization of styrene, methacrylic acid, and the fluorescent monomer. Latexes are characterized by measuring styrene/methacrylic acid conversion, average particle diameter, fluorescence, surface charge, and group density. Conversion reaches ≈90%, and negatively charged particles of 130–260 nm are obtained, which proved to have high fluorescence with an emission maximum of 511 nm. Cell fluorescent staining is carried out using the obtained particles. Observation of the FLP‐treated cells by confocal microscopy exhibited intense fluorescence within all the internal media, with a fluorescein‐like emission pattern. The production of stable fluorescent particles, with controlled size and high fluorescein incorporation, capable of interacting with proteins and cells efficiently, is confirmed.
AWSD Reactive Burn Model for High Explosive LX‐14
Authors: Craven Galen T , Ticknor Christopher 
Published: February 2025

ABSTRACTThe results of an Arrhenius–Wescott–Stewart–Davis (AWSD) reactive flow calibration for the HMX‐based high explosive LX‐14 are presented. The parameters in the AWSD model are calibrated to experimental thermodynamic and gas gun data and to computational results from thermochemical calculations. There is no experimental rate stick data available for LX‐14; therefore, scaled experimental results from other PBX‐based high explosives are used in the calibration to fill this gap in data. Strong agreement is observed between the calibrated AWSD model and experimental data for LX‐14, including validation data that were not used in the calibration procedure. The developed model more accurately describes experimental shock‐to‐detonation results compared to several other reactive flow models for LX‐14 from the literature. The presented results illustrate that the AWSD model is capable of quantitatively describing the reactive burn of LX‐14.
Physiotherapists' Use of Attentional Focus Instructions and Feedback in the Philippines: A Survey Study
Authors: Eguia Kathlynne F. , Ng Shamay S. M. , Wong Thomson W. L. 
Published: February 2025

ABSTRACTBackground and PurposeVerbal instructions and feedback are critical motor learning elements within physiotherapy practice. With evident advantages associated with instructions and feedback that direct learner attention externally, it has been recommended that knowledge about the focus of attention (FOA) be translated into physiotherapy practice. However, most existing information on this topic comes from non‐Asian and high‐resourced settings. This study aims to fill the knowledge gap regarding context‐specific practice patterns by examining the preferences of physiotherapists in the Philippines for external or internal FOA when delivering instructions and feedback across various practice areas. We also explored how professional characteristics relate to these preferences and considerations for delivering instructions and feedback.MethodsThis study employed a cross‐sectional survey design. A total of 223 physiotherapists completed an online survey, of which 182 answered questions on their preferences for external or internal FOA based on clinical scenarios. The survey also collected information on participants' professional and practice backgrounds, conscious planning in delivering instructions and feedback, and considerations for varying instructions and feedback.ResultsThe participants tended to prefer internal FOA for delivering instructions and feedback, which was not associated with educational background, years of experience, specialisation, geographic region, practice setting, or FOA familiarity. While only approximately half of the respondents were familiar with the concept of FOA, the majority tended to consciously plan the delivery of instructions and feedback based on clients' cognitive and impairment levels.DiscussionThere is an overall preference for internal FOA for delivering instructions and feedback among physiotherapists in the Philippines. Work is needed to enhance practitioners' knowledge of the evidence related to FOA and to facilitate knowledge translation that enables the utilisation of research in physiotherapy practice.
Special Issue Young People's Caring Practices in Transnational Families in Sweden and the UK: Care Ethics and Wellbeing
Authors: Suter Brigitte , Evans Ruth , Giralt Rosa Mas , Mozetič Katarina 
Published: February 2025

ABSTRACTChildren are often regarded as ‘dependents’ within migration studies, rendering their care work invisible. Drawing on the ethics of care, this paper analyses young people's active roles in caring for family members in Sweden and the UK and for transnational kin, based on qualitative and participatory research with young people (aged 6–25). Many young people provided emotional support, language brokering and practical assistance to navigate care, welfare and immigration systems. Some young people engaged in higher levels of caregiving, often linked to inadequate formal care resources and the absence of a parent or extended kin who would usually be expected to provide care. Caregiving was often accompanied by gendered and inter‐ and intra‐generational conflicts, which could impact on young people's wellbeing and competence to provide ‘good care’. More awareness is needed of young people's crucial roles in filling the gaps in care, welfare and migration regimes in transnational spaces.