bluuebunny/crossref_metadata_2025_split huggingface dataset:
THE OPENING OF HISTORICAL FUTURES*
Authors: Simon Zoltán Boldizsár , Tamm Marek 
Published: June 2024

ABSTRACTWith a touch of irony, the project‐closing piece of the “Historical Futures” collective research endeavor pulls together the threads of its four years of explorative work by showcasing an opening of historical futures. Against the persisting myth of the closure of the future in contemporary societies, it claims that, as long as the future remains contested by virtue of the multiplicity of historical futures that societal practices and discourses entail or advocate, there can be no closure of the future. In support of this claim, the project‐closing piece outlines the reasons why the future is more radically open than ever and surveys the findings of the project contributions with the frame provided by the contemporary opening of historical futures.
Modelling thermal characteristics of cocoa butter using a feed‐forward artificial neural network based on multilayer perceptron
Authors: Rostami Omid , Saberi Farzad , Mohammadi Amirreza , Kamalirousta Leila , Rosell Cristina M. , Gasparre Nicola 
Published: June 2024

SummaryCocoa butter is the most important ingredient of chocolate, which determines its melting behaviour. Variations in the melting characteristics of cocoa butter can profoundly affect the performance and suitability for their industrial utilisation. Over time, researchers have been attempting to establish a logical relationship between cocoa butter's unique thermal properties and the amount of saturated to unsaturated fatty acids in mono, di and triglycerides, and fatty acids (as major components), and free fatty acids, soap, primary oxidation products, minerals, moisture, phospholipids, tocopherols, unsaponifiable matters and metals (as minor components) found in cocoa butter. In this research, the thermal behaviours of thirteen samples of cocoa butter with different origins were investigated using isothermal differential scanning calorimetry. The cocoa butters starting temperature of crystallisation, temperature of maximum heat release, temperature of completed crystallisation and the enthalpy of heat release during recrystallisation were evaluated. In addition, the chemical composition (moisture, acidity, peroxide, minerals and soap content), fatty acid and triacylglycerol composition were used to establish an MLP‐ANN with fourteen input neurons connected by two flexible, sigmoid activation function layers. The back‐propagation was used to train the artificial neural network (ANN) structure and optimise the error of prediction. The study showed that the MLP algorithm can predict the thermal behaviour of CB samples with trace error, regardless of plant growth and extract process condition.
High‐resolution HLA sequencing and hypocretin receptor 2 autoantibodies in narcolepsy type 1 and type 2
Authors: Hamdan Samia , Wasling Pontus , Lind Alexander 
Published: June 2024

AbstractNarcolepsy is a sleep disorder caused by an apparent degeneration of orexin/hypocretin neurons in the lateral hypothalamic area and a subsequent decrease in orexin/hypocretin levels in the cerebrospinal fluid. Narcolepsy is classified into type 1 (NT1) and type 2 (NT2). While genetic associations in the human leukocyte antigen (HLA) region and candidate autoantibodies have been investigated in NT1 to imply an autoimmune origin, less is known about the pathogenesis in NT2. Twenty‐six NT1 and 15 NT2 patients were included, together with control groups of 24 idiopathic hypersomnia (IH) patients and 778 general population participants. High‐resolution sequencing was used to determine the alleles, the extended haplotypes, and the genotypes of HLA‐DRB3, ‐DRB4, ‐DRB5, ‐DRB1, ‐DQA1, ‐DQB1, ‐DPA1, and ‐DPB1. Radiobinding assay was used to determine autoantibodies against hypocretin receptor 2 (anti‐HCRTR2 autoantibodies). NT1 was associated with HLA‐DRB5*01:01:01, ‐DRB1*15:01:01, ‐DQA1*01:02:01, ‐DQB1*06:02:01, ‐DRB5*01:01:01, ‐DRB1*15:01:01, ‐DQA1*01:02:01, ‐DQB1*06:02:01 (odds ratio [OR]: 9.15; p = 8.31 × 10−4) and HLA‐DRB5*01:01:01, ‐DRB1*15:01:01, ‐DQA1*01:02:01, ‐DQB1*06:02:01, ‐DRB4*01:03:01, ‐DRB1*04:01:01, ‐DQA1*03:02//03:03:01, ‐DQB1*03:01:01 (OR: 23.61; p = 1.58 × 10−4) genotypes. Lower orexin/hypocretin levels were reported in the NT2 subgroup (n = 5) that was associated with the extended HLA‐DQB1*06:02:01 haplotype (p = .001). Anti‐HCRTR2 autoantibody levels were not different between study groups (p = .8524). We confirmed the previous association of NT1 with HLA‐DQB1*06:02:01 extended genotypes. A subgroup of NT2 patients with intermediate orexin/hypocretin levels and association with HLA‐DQB1*06:02:01 was identified, indicating a possible overlap between the two distinct narcolepsy subtypes, NT1 and NT2. Low anti‐HCRTR2 autoantibody levels suggest that these receptors might not function as autoimmune targets in either NT1 or NT2.
The role of split‐thickness skin grafting in the treatment of vasculitic and pyoderma gangrenosum ulcers in a multidisciplinary wound centre
Authors: Suoniemi Laura , Salmi Teea , Huhtala Heini , Kaartinen Ilkka , Kiiski Juha , Kimpimäki Teija 
Published: June 2024

AbstractVasculitic and pyoderma gangrenosum ulcers are traditionally treated with immunosuppressants, and the role of surgery in the treatment of these atypical ulcers remains unclear. This study aimed to investigate the need for surgical intervention as well as the outcome and safety of skin grafting in the treatment of 46 patients with vasculitic ulcers and 34 with pyoderma gangrenosum ulcers using data recorded in the validated Wound Registry. Of the 80 patients with atypical ulcers, 14% (n = 11) were treated surgically; these patients were older (p = 0.039), had lower mobility status (p = 0.002), and more often pulmonary diseases, rheumatoid arthritis, and previous arterial procedures (p = 0.007; p = 0.031; p = 0.031, respectively) than those treated conservatively. Of 181 ulcers, 15% (n = 27) were surgically treated, 78% once and 22% multiple times. During follow‐up, 92.3% of both surgically and conservatively treated ulcers with available data healed. Of the surgically treated ulcers, median healing time after first surgical procedure was 96 days, and post‐surgical complications were considered mild or unrelated to surgery. Our results suggest that if surgery is indicated, skin grafting is a safe and efficient treatment method provided that multidisciplinary approach is applied.
Real‐world evidence demonstrates an appropriate atrial fibrillation population for hybrid convergent approach versus stand‐alone cryoballoon ablation: A long‐term safety and efficacy study
Authors: Lorenzo Christian , Ortiz‐Gonzalez Yahaira , Hill Dustin , Kinaga Jennifer , Filart Lauren , Bello David , Duran Aurelio , Bott Jeffery , Patel Shivangi , Sendin Mary Janette , Filart Roland 
Published: June 2024

AbstractIntroductionA hybrid convergent approach (endocardial and epicardial ablation) demonstrated superior effectiveness in a recent randomized study for long‐standing persistent atrial fibrillation (LSPAF). Yet, there is a lack of real‐world, long‐term evidence as to which patients are best candidates for a hybrid convergent approach compared to standard endocardial cryoballoon pulmonary vein isolation (CB PVI).Methods and ResultsThis single‐center, retrospective analysis spanning from 2010 to 2015 compared two distinctly different atrial fibrillation (AF) cohorts; one treated with stand‐alone cryoablation and one treated with a hybrid convergent approach. Baseline characteristics described candidates for each approach. The following criteria were utilized to determine CB PVI candidacy: (1) paroxysmal AF (PAF) (stage 3A) with failed class I/III antiarrhythmic drug (AAD) or (2) persistent/LSPAF (stage 3B/3C/3D) with failed class I/III AAD unwilling to undergo hybrid procedure. Selection criteria for the hybrid procedure included: (1) PAF refractory to both class I/III AAD and prior CB PVI (stage 3D) or (2) persistent/LSPAF (stage 3B/3C/3D) with failed class I/III AAD agreeable to hybrid procedure. Prior sternotomy was excluded. Serial electrocardiograms and continuous monitoring evaluated primary efficacy outcome of time‐to‐first recurrence of atrial arrhythmia after a 90‐day blanking period. Secondary outcomes were procedure‐related complications and AAD use (at discharge, 12, and 36 months). Kaplan‐Meier methods evaluated arrhythmia recurrence. Of 276 patients, 197 (64.2 ± 10.6 years old; 66.5% male; 74.1% 3A‐PAF; 18.3% 3B/3D‐persistent AF; 1.0% 3C‐LSPAF; 6.6% undetermined) underwent CB PVI and 79 (61.4 ± 8.1 years old; 83.5% male; 41.8% 3D‐PAF; 45.5% 3B/3D‐persistent AF; 12.7% 3C/3D‐LSPAF) underwent hybrid procedure. Arrhythmia freedom through 36 months was 55.2% for CB PVI and 50.4% for hybrid (p = .32). Class I AAD utilization at discharge occurred in 38 (19.3%) patients in the CB PVI group and 5 (6.3%) patients in the hybrid group (p = .01). CB PVI class I AAD utilization at 12 months occurred in 14 (9.0) patients versus 0 patients for hybrid convergent (p = .004). Patients with one or more adverse event were as follows: two (1.0%) in the CB PVI group (both transient phrenic nerve palsy) and three (3.7%) in the hybrid group (two with significant bleeding and one with wound infection) (p = .14).ConclusionThis study demonstrated that patients with more complex forms of AF (3D‐PAF or 3B/3C/3D‐persistent/LSPAF) could be well managed with a convergent approach. In a real‐world evaluation, outcomes match safety and efficacy thresholds achieved for patients with earlier, less complex AF etiologies treated by CB PVI alone.
Efficacy and safety of same‐day preparation with sodium picosulfate plus magnesium citrate on the day of colonoscopy for bowel preparation: Multicenter, single‐arm, open‐label study
Authors: Hori Hitomi , Ikezawa Nobuaki , Tanaka Shinwa , Ueda Chise , Fujisawa Mizuho , Hoki Shinya , Tanabe Hiroshi , Ishida Ryosuke , Okamoto Norihiro , Takayama Hiroshi , Miyazaki Haruka , Sakaguchi Hiroya , Kinoshita Masato , Abe Hirofumi , Yoshizaki Tetsuya , Ooi Makoto , Takao Madoka , Morita Yoshinori , Toyonaga Takashi , Kodama Yuzo 
Published: June 2024

AbstractBackground and AimSodium picosulfate plus magnesium citrate (SP + MC) is a well‐tolerated bowel preparation agent. However, Japan currently approves only two methods of taking SP + MC: the day‐before and split‐dose preparation, without approval of same‐day preparations. This study aimed to evaluate the efficacy and safety of same‐day SP + MC preparations.MethodsThis was a multicenter, single‐arm, nonrandomized, open‐label study. We enrolled 145 Japanese patients between June and December 2023. The patients received two sachets of SP + MC dissolved in 300 ml of water and 1200 mL or more of clear liquid on the day of colonoscopy. Bowel cleansing efficacy, adverse events (AEs), and patient satisfaction were evaluated.ResultsOf the enrolled patients, 137 underwent colonoscopy according to our protocol. Bowel preparation was adequate in 133 patients (97.1%). The mean total Boston Bowel Preparation Score was 8.3 ± 1.2. Five patients experienced AEs (3.6%): two (1.5%), abdominal pain; one (0.73%), ischemic enteritis; one (0.73%), vomiting or nausea; and one (0.73%), headache. All AEs were treated conservatively. None of the patients exhibited abnormal blood test results or clinical symptoms after receiving SP + MC. Regarding patient satisfaction, all patients were able to take SP + MC as directed; 136 (99.2%) expressed a preference for this bowel preparation for future colonoscopies.ConclusionThe same‐day SP + MC preparation showed high bowel‐cleansing efficacy and satisfaction in Japanese patients without serious AEs.
Epifluorescence microscopy study of a quadruple node of triple junctions of grain boundaries in a Eu2+‐decorated highly textured composite of (Cl, Br)(K, Rb) and I(K, Rb) solid solutions
Authors: Cordero‐Borboa A. E. , Unda‐Angeles R. 
Published: June 2024

AbstractThe structural nature and geometry, as well as the lattice‐relative orientation, of an arrangement of crystal defects in a highly textured Eu2+‐doped composite of two alkali‐halide solid solutions was studied by epifluorescence microscopy (EFM) using the doping ion as a fluorochrome. A three‐dimensional reconstruction and a skeleton type model, as built from a sequence of EFM images of different optical cross‐sections of this arrangement, are presented. Structurally, this arrangement is a quadruple node (QN) of triple junctions of grain boundaries. The QN core geometry is that of a tetragonal tristetrahedron (TTTH), centred at the QN site, whose tetrahedron vertices and edges are on the QN triple junctions and grain boundaries, respectively, whereas the tristetrahedron tetragonal axis is nearly parallel to the lattice [001]‐axis. The measured values of the angles between triple junctions and between the grain boundaries forming them are reported. The distinct chemical compositions of the composite solid solutions are discussed to be responsible, in last instance, for the tristetrahedron departure from a cubic configuration. Collaterally, certain families of translationally periodic almost‐parallel (TPAP)‐wall‐like regions which consist of TPAP‐columns of TPAP‐spindle‐like singularities, as well as certain zigzag arrays of columns of this like, existing into the QN grains, are reported to be observed. Three‐dimensional reconstructions of typical individuals of these families and arrays as well as of their constituent parts are presented and geometrically analysed. These families and arrays are discussed to be families of tilt subboundaries, whose constituent dislocations are decorated by cylindrical second‐phase europium di‐halide precipitates, and regularly faceted tilt subboundaries, respectively. Crystal growing and sample preparation, composite structural characterisation by powder and single‐slab X‐ray diffraction (PXRD and SSXRD, respectively), microscopy and fluorescence‐cube unit optics, image processing, electronic three‐dimensional reconstruction and measuring methodologies, are all described in detail.
Investigating the impact of botulinum toxin type a on the migration of normal human dermal fibroblasts: An in vitro wound healing assay
Authors: Thanasarnaksorn Wilai , Pomsoong Cherrin , Kanjanasirirat Phongthon , Jearawuttanakul Kedchin , Borwornpinyo Suparerk , Hongeng Suradej , Ratanapokasatit Yanisa , Rattananukrom Teerapong 
Published: June 2024

AbstractBackgroundBotulinum toxin A (BoNT‐A) is widely utilized in the management of hypertrophic and keloid scars. One proposed mechanism for scar prevention involves the inhibition of fibroblast migration in scars by BoNT‐A. However, the data regarding the effect of BoNT‐A on the migration of normal human dermal fibroblasts (NHDF) is limited.ObjectivesThe aim of this study was to investigate the inhibitory effect of different types and dilutions of BoNT‐A on the migration of NHDF.MethodsIn vitro scratch wound assay, NHDF cells were cultured, incubated, and subjected to scratching using a sterile tip. Subsequently, the scratched NHDF monolayer was treated with different types of BoNT‐A, including onabotulinumtoxinA (ONA), incobotulinumtoxinA (INCO), prabotulinumtoxinA (PRABO), or letibotulinumtoxinA (LETI), at varying concentrations of 10, 20, 25, 40, 50, and 100 units/milliliter (U/mL). Additionally, abobotulinumtoxinA (ABO) was administered at concentrations of 33, 50, 66, 71, 100, 150, 300, and 500 U/mL. Normal saline solution (NSS) served as a negative control. The extent of NHDF migration was evaluated by comparing each dilution of BoNT‐A with the controls using high‐content imaging at the 48‐h time point. Furthermore, the viability of the of NHDF was assessed.ResultsThe concentrations of 25, 40, and 50 U/mL of ONA (p < 0.001) and 25 U/mL of LETI (p < 0.05) demonstrated significantly inhibited NHDF migration in comparison to the control group. Conversely, all dilutions of PRABO, INCO, and ABO exhibited comparable NHDF migration to that of the control group. Regarding NHDF viability, no significant decrease was observed across any of the BoNT‐A types and dilutions.ConclusionDifferent types and dilutions of BoNT‐A demonstrated variable inhibitory effects on NHDF migration in vitro. The selection of BoNT‐A formulation may significantly impact the clinical outcome of scar prevention related to fibroblast migration.
Implementing purpose‐studies: A humanising approach for bridging the spaces between writers, their worlds and the test
Authors: Land Charlotte L. , Elliot Alison Eike , McKinnon Barbara 
Published: June 2024

AbstractTeachers of young writers often feel pressure to focus on narrow, tested conventions, forms and processes of writing. These pressures can contribute to instruction that does not consider students' interests, experiences, language or cultures, but rather can further deficit views of students whose backgrounds do not closely align with those making decisions about what counts as writing in schools. This paper explores purpose‐studies—an alternative to genre‐studies—Barbara, a fourth‐grade teacher, and Alison, a ninth‐grade teacher, used to help balance the needs of their students, position students as strong and capable writers and prepare students to write for the test and the world beyond the school walls.
The impact of space, host dissimilitude, and environment on prokaryotic communities of golf ball sponges
Authors: Cleary Daniel F. R. , de Voogd Nicole J. 
Published: June 2024

AbstractGolf ball sponges are small, sometimes inconspicuous, sponges. They can be found across a range of habitats varying from perturbed and pristine coral reefs to harbours and marine lakes and from the deep sea to shallow waters. They can be difficult to distinguish in the field and have presented some problems with taxonomists lumping and splitting species due to the difficulty in defining clear species boundaries. In the present study, we sampled golf ball sponges from Indo‐Pacific and Caribbean locations and used 16S gene amplicon sequencing to study their prokaryotic communities. We show that golf ball sponges harbour a wide variety of prokaryotic communities. Among the most prevalent operational taxonomic units (OTUs), several belonged to a range of taxa, including the bacterial AqS1 and EC94 groups, which have been associated with genes known to facilitate interactions between hosts and microbes. Certain host taxa were enriched with OTUs classified to the SAR202 clade of Chloroflexi. Our findings show that prokaryotic dissimilarity varied as a function of space (geographical distance) and host dissimilitude. The importance of space and host dissimilitude, however, varied depending on the data transformation with host dissimilitude a more important predictor of untransformed data whereas space was a more important predictor of log‐transformed data. Given that log‐transformation downscales the influence of abundant taxa, we interpret these results by the tendency of closely related host organisms to host similar sets of abundant symbiotic microorganisms; distantly sampled specimens, in contrast, tend to harbour less abundant prokaryotic microorganisms found in the surrounding environment (e.g., seawater or sediment).
On the philosophical proofs of absolute death by schizophrenia
Authors: Li Kuo 
Published: June 2024

AbstractThis paper begins by elucidating two common features in the application from spirit to the material world of objective idealism: first, all main representatives take the Absolute as the way to think about the inner negative foundation of spirit and, second, the Absolute has a self‐negation processual structure, which exits itself and then returns to itself. The paper points out that the exit‐return model can explain the objective world very well and meanwhile maintain the integrity of the spiritual ontology, in which the return to the Absolute is crucial. After the scientific revolution, the Enlightenment, and two world wars, however, followed by the development of irrational thinking, positivism, and practical philosophy, the Absolute ceased to be the foundation of spiritual functioning. The return to the Absolute points to emptiness, and exit without return creates persistent schizophrenia, while subverting the ontological foundation of concepts and language, objects and humankind.
„Nichts verlangte er von seiner Umwelt, außer dass er sie provozieren und vor den Kopf stoßen durfte“: Jesus‐Figuren in der modernen deutschsprachigen und polnischen Literatur
Authors: Jakubów Marek 
Published: June 2024

ZusammenfassungDie zahlreichen Romane in der deutschsprachigen und polnischen Literatur, die in den letzten, durch die Säkularisierungsprozesse geprägten Jahrzehnten erschienen sind und die Figur Jesu thematisieren, bilden kein einheitliches Phänomen und ergeben aus komparatistischer Sicht erhebliche Differenzen. Sie sind auf die andersartigen Deutungsmuster der romantischen Tradition zurückzuführen. Wenn sich im deutschsprachigen Raum in der der Konstruktion der Jesus‐Figur die Tendenz zur Überschreitung des durch die Sprache bestimmten Erkenntnisradius manifest macht, gilt sie bei den polnischen Autoren als überlieferter und ständig präsenter Teil des Bewusstseins, der in kritischer Hinterfragung seine Wandlungsetappen nach der Wendezeit markiert.
Integrating GWAS, RNA‐Seq and functional analysis revealed that BnaA02.SE mediates silique elongation by affecting cell proliferation and expansion in Brassica napus
Authors: Zhang Liyuan , Yang Bo , Li Xiaodong , Chen Si , Zhang Chao , Xiang Sirou , Sun Tingting , Yang Ziyan , Kong Xizeng , Qu Cunmin , Lu Kun , Li Jiana 
Published: June 2024

SummaryRapeseed (Brassica napus) silique is the major carbohydrate source for seed development, and the final silique length has attracted great attention from breeders. However, no studies had focused on the dynamic character of silique elongation length (SEL). Here, the dynamic SEL investigation in a natural population including 588 lines over two years indicate that dynamic SEL during 0–20 days after flowering was the most essential stage associated with seed number per silique (SPS) and thousand seed weight (TSW). Then, nine loci were identified to be associated with SEL based on GWAS analysis, among which five SNPs (over 50%) distributed on the A02 chromosome within 6.08 to 6.48 Mb. Subsequently, we screened 5078 differentially expressed genes between two extreme materials. An unknown protein, BnaA02.SE, was identified combining with GWAS and RNA‐Seq analysis. Subcellular localization and expression profiles analysis demonstrated that BnaA02.SE is a chloroplast‐ and nucleus‐localized protein mainly expressed in pericarps and leaves. Furthermore, transgenic verification and dynamic cytological observation reveal that overexpressed BnaA02.SE can promote silique elongation by regulating JA and IAA contents, affecting cell proliferation and expansion, respectively, and finally enhance seed yield by influencing SPS and TSW. Haplotype analysis reveal that the homologs of BnaA02.SE may also be involved in silique elongation regulation. Our findings provided comprehensive insights into a newly SEL trait, and cloned the first gene (BnaA02.SE) controlling silique elongation in B. napus. The identified BnaA02.SE and its homologs can offer a valuable target for improving B. napus yield.