bluuebunny/crossref_metadata_2025_split huggingface dataset:
Zoonotic spillover and extreme weather events drive the global outbreaks of airborne viral emerging infectious diseases
Authors: Wang Zekun , Pei Shaojun , Cui Haoliang , Zhang Jianyi , Jia Zhongwei 
Published: June 2024

AbstractOutbreaks of airborne viral emerging infectious diseases (EIDs) cause an increasing burden on global public health, particularly with a backdrop of intensified climate change. However, infection sources and drivers for outbreaks of airborne viral EIDs remain unknown. Here, we aim to explore the driving mechanisms of outbreaks based on the one health perspective. Outbreak information for 20 types of airborne viral EIDs was collected from the Global Infectious Disease and Epidemiology Network database and a systematic literature review. Four statistically significant and high‐risk spatiotemporal clusters for airborne viral EID outbreaks were identified globally using multivariate scan statistic tests. There were 112 outbreaks with clear infection sources, and zoonotic spillover was the most common source (95.54%, 107/112). Since 1970, the majority of outbreaks occurred in healthcare facilities (24.82%), followed by schools (17.93%) and animal‐related settings (15.93%). Significant associations were detected between the number of earthquakes, storms, duration of floods, and airborne viral EIDs' outbreaks using a case‐crossover study design and multivariable conditional logistic regression. These findings implied that zoonotic spillover and extreme weather events are driving global outbreaks of airborne viral EIDs, and targeted prevention and control measures should be made to reduce the airborne viral EIDs burden.
Incidence of pulmonary vein stenosis in two types of cryoballoon systems
Authors: Shiomi Satoko , Tokuda Michifumi , Sakurai Ryutaro , Yamazaki Yoshito , Matsumoto Takuya , Sato Hidenori , Oseto Hirotsuna , Yokoyama Masaaki , Tokutake Kenichi , Kato Mika , Yamashita Seigo , Yamane Teiichi , Yoshimura Michihiro 
Published: June 2024

AbstractBackgroundCurrently, two types of cryoballoon (CB) systems are available for catheter ablation of atrial fibrillation (AF). Since the POLARx (Boston Scientific) is softer during freezing than the Arctic Front Advance Pro (AFA‐Pro; Medtronic), it tends to go more deeply into the pulmonary vein (PV), risking PV stenosis.MethodsNinety‐one patients underwent initial CB ablation for paroxysmal AF (AFA‐Pro 56; POLARx 35). Twenty‐six from each group were extracted using propensity score matching. The PV cross‐sectional area (PVA) was measured by tracing the area within the PV plane at 5‐mm intervals from the PV ostium in a distal direction for 20 mm or to the bifurcation in each PV. The PVA was compared before and 3 months after ablation.ResultsTime to balloon temperatures of −30 and − 40°C was significantly shorter and the nadir temperature was significantly lower with POLARx than with AFA‐Pro. In the left inferior (LI) PV and right superior (RS) PV, the freezing balloon position was significantly deeper in POLARx than in AFA‐pro. The freezing position in RSPV with mild to moderate narrowing was deeper than those without (10.2 ± 3.3 mm vs. 8.2 ± 1.8 mm, p = .01). In RSPV, the reduction of PVA tended to be greater with the POLARx than with the AFA‐Pro (26.1% ± 14.1% vs. 19.9% ± 10.3%, p = .07).ConclusionThere was no significant difference in the incidence of PV stenosis between POLARx and AFA‐Pro. However, if POLARx goes deep into the PVs, we will still have to be careful.
The Semantic Integration of Multiple Unconscious Stimuli in Creative Problem‐Solving
Authors: Liu Chengzhen , Huang Qianling , Li Geng , Xu Dahong , Li Xi , Shi Zifu , Tu Shen 
Published: June 2024

ABSTRACTThe process of creative problem‐solving (CPS) commonly demands that individuals consciously or unconsciously integrate creative ideas from a vast array of diverse information. Using a masked priming paradigm and the Chinese remote associates test (RAT), this study provides innovative behavioral evidence for the integration of multiple unconscious stimuli during CPS. In Experiment 1, three masked Chinese characters were simultaneously presented in the RAT, the first and third characters could be combined to form an answer. Two Chinese two‐character words were presented in parallel, each containing the answer in Experiment 2, and required the complete word information to be split and subsequently re‐integrated in a more complex manner than in Experiment 1. Interestingly, in both the experiments, multiple unconsciously processed stimuli generated a priming effect on creative performance. Specifically, a positive priming effect was observed in response to the difficult RATs, whereas a negative priming effect was observed in response to the easy RATs. Overall, our study verified that semantic integration between different unconsciously perceived stimuli can occur, which provides insights into the mechanisms underlying unconscious priming effects and contributes to a better understanding of how creative cognitive processing is influenced by multiple types of unconscious information.
Internalizing and externalizing behaviors in children and adolescents with Wilson's disease in the context of quality of life
Authors: Biernacka Marta , Jakubowska‐Winecka Anna , Biernacki Marcin , Janowski Kamil , Jańczyk Wojciech , Socha Piotr 
Published: June 2024

AbstractPatients with Wilson's disease (WD) are at increased risk of poor quality of life (QoL) and social‐emotional outcomes. The above data has been well established in the adult population. What are the predictors of QoL in children and adolescents with WD are unknown. Our study examined whether subjective feelings about QoL are related to the psychosocial functioning in paediatric patients. A cross‐sectional study among 50 children with WD, aged 7–18 years. Participants completed the KINDL QoL questionnaire and the Child Behavior Checklist assessing internalizing and externalizing behaviors. Internalizing and externalizing behaviors and their interaction are significant in predicting the QoL of children with WD. Internalizing behaviors are significant predictor of the QoL β = −0.328 (p < 0.05). The effect of internalizing behavior on the QoL varies with the level of externalizing behavior β = −0.344* (p < 0.05). Simple effects analysis indicates that the highest QoL for children with WD is in the group characterized by both low levels of internalizing and medium levels of externalizing behaviors, t = −3.052 (df = 46) and p < 0.01, or high levels of externalizing behaviors, t = −2.725 (df = 46) p < 0.01. The interaction between internalizing behaviors explained an additional 7.5% of the variance in scores on the QoL scale. Overall, the final regression model explained 14.9% of the scores on the QoL scale. Monitoring internalizing and externalizing behaviors will allow a better understanding of the course of treatment. In chronic disease, the QoL is an aspect that determines the doctor‐patient relationship and often determines the course of the therapeutic process.
Effect of γ‐oryzanol/β‐sitosterol‐based oleogels on the physicochemical and gel properties of Nemipterus virgatus myofibrillar protein
Authors: Mi Hongbo , Yang Yingci , Yi Shumin , Li Jianrong , Chen Jingxin , Li Xuepeng 
Published: June 2024

AbstractBACKGROUNDThe effect of oleogels prepared with peanut oil and different concentrations of γ‐oryzanol and β‐sitosterol mixture (γ/β; 20, 40, 60, 80 and 100 g kg−1) on the physicochemical and gel properties of myofibrillar protein (MP) was investigated.RESULTSThe solubility and average particle size of MP first decreased and then increased with increasing γ/β concentration. Peanut oil or oleogels could induce the exposure of hydrophobic amino acids and the unfolding of MP, thus significantly increasing the surface hydrophobicity, sulfhydryl content and absolute value of zeta potential, which reached maximum values when the γ/β concentration was 60 g kg−1 (P < 0.05). The addition of peanut oil decreased the gel strength and water holding capacity of MP gel. However, oleogels prepared with 60 g kg−1 γ/β could significantly increase the hydrophobic interactions and disulfide bond content of MP gel (P < 0.05), which promoted the crosslinking and aggregation of MP, enhancing the gel properties. Peanut oil had no significant influence on the secondary structure of MP, while oleogels promoted the transition of MP conformation from α‐helix to β‐sheet structure. The results of light microscopy and confocal laser scanning microscopy indicated that oleogels prepared with 60 g kg−1 γ/β filled in the pores of MP gel network to form denser and more uniform structure.CONCLUSIONOleogels prepared with 60 g kg−1 γ/β could effectively improve the quality of MP gel and have promising application prospects in surimi products. © 2024 Society of Chemical Industry.
Radiology–Pathology Concordance and Prognostication of Nodal Features in pN+ Oral Cavity Cancer
Authors: Duguet‐Armand Marie , Su Jie , O'Sullivan Brian , de Almeida John , Hosni Ali , Weinreb Ilan , Perez‐Ordonez Bayardo , Smith Stephen , Witterick Ian , Yao Christopher , Goldstein David , Hope Andrew , Hahn Ezra , Waldron John , Ringash Jolie , Spreafico Anna , Yu Eugene , Huang Shao Hui 
Published: June 2024

Background and PurposeThe aims of our study are to evaluate the diagnostic performance and prognostic value of radiological lymph node (LN) characteristics in pN+ oral cavity squamous carcinoma (OSCC).Materials and MethodspN+ OSCC treated between 2012 and 2020 were included. Preoperative imaging was reviewed by a single radiologist blinded to pathologic findings for the following nodal features: imaging‐positive LN (iN+), laterality and total number, and image‐identified extranodal extension (iENE). The sensitivity of iN+ for pN+ was calculated. The diagnostic performance of other nodal features was evaluated in the iN+ subgroup. The association of radiologic nodal features with overall survival (OS) was evaluated. Inter‐rater kappa for radiologic nodal features was assessed in 100 randomly selected cases.ResultsOf 406 pN+ OSCC, 288 were iN+. The sensitivity of iN+ for pN+ was 71% overall, and improved to 89% for pN+ LN >1.5 cm. Within iN+, sensitivity/specificity for LN size (>3 cm), total LN number (>4), and ENE were 0.44/0.95, 0.57/0.84, and 0.27/0.96, respectively. Sensitivity of iENE was higher in the subset, with major (>2 mm) versus minor (≤2 mm) pENE (43% vs. 13%, p = 0.001). Reduced OS was observed in iN+ versus iN– (p = 0.006), iENE+ versus iENE– (p = 0.004), LN size >3 versus ≤3 cm (p < 0.001), and higher LN number (p < 0.001). Inter‐rater kappa for iN+, laterality, total LN number, and presence of iENE were 0.71, 0.57, 0.78, and 0.69, respectively.ConclusionOur study shows that despite modest sensitivity of most radiological nodal features, the specificity of image‐identified nodal features is high and their prognostic values are retained in pN+ OSCC.Level of Evidence3 (retrospective review comparing cases and controls) Laryngoscope, 134:4947–4955, 2024
Crosslinking Vinyl‐Addition Polynorbornenes via Difunctional Diazirines to Generate Low Dielectric‐Constant and Low Dielectric‐Loss Thermosets
Authors: Kandanarachchi Pramod , Meyer Gerhard A. , Musolino Stefania F. , Wulff Jeremy E. , Rhodes Larry F. 
Published: June 2024

AbstractThermosets having low dielectric constant (Dk < 3) and low dielectric dissipation factor (Df < 0.003), high glass transition temperature (Tg > 150 °C), and good adhesion to copper are desirable for the low loss layers of the copper clad laminates (CCL) in next generation printed circuit boards. Three different difunctional diazirines are evaluated for both thermal and photochemical crosslinking of a high Tg vinyl‐addition polynorbornene resin: poly(5‐hexyl‐1‐norbornene) (poly(HNB)). The substrate polymer, crosslinked by the carbenes generated from the activated diazirines, forms thermosets with Dk < 2.3 and Df < 0.001 at 10 GHz depending on the identity of the diazirine and the loading. The Dk and Df values for one composition are stable for 1600 h at 125 °C in air and for 1400 h at 85 °C and 85% relative humidity, suggesting good long‐term reliability of this thermoset. Adhesion of poly(HNB) to copper can be enhanced by priming the copper surface with a diazirine prior to high temperature lamination; peel strength values of greater than 7.5 N cm−1 are achieved. Negative‐tone photopatterning of poly(HNB) with diazirines upon exposure to 365 nm light is demonstrated.
Silver Coated Multifunctional Liquid Crystalline Elastomer Polymeric Composites as Electro‐Responsive and Piezo‐Resistive Artificial Muscles
Authors: Ince Joshua C. , Duffy Alan R. , Salim Nisa V. 
Published: June 2024

AbstractLiquid crystalline elastomers (LCEs) are a class of shape‐changing polymers with exceptional mechanical properties and potential as artificial muscles/polymer actuators. In this study, multifunctional LCE actuators with strain sensing and joule heating responsivity are developed. LCEs are successfully synthesized using the thiol‐ene two‐staged michael addition polymerization (TMAP) method. The LCE films are further functionalized via sequential polydopamine (PDA) and silver electroless coating. It is found that the PDA coating enabled the anchoring of the Ag particles to the LCE, thereby enabling the electrical conductivity of the Ag‐LCEs (<0.1 Ω cm−1). The studies confirm that the Ag/PDA coated LCEs can sense up to ≈30% strain, sense their own actuation strokes, and actuate at a rate of 1.83% s−1 while lifting a weight ≈50 times its mass in response to a 12 V 2A DC current.
Integration of proteinogenic amino acids in the pathogenesis of schizophrenia
Authors: Carvalho Michelle S. , Sforca Mauricio Luis , Rocco Silvana Aparecida , Furtado Danielle Zildeana Sousa , Silverio Cristiane da Silva , Nunes Marielle F. Queiroz , Vella Nunes Marcel , Adelino Marcelo P. Machado , Afonso dos Santos Leonardo , Jackowski Andrea , Affonseca Bressan Rodrigo , Lacerda Acioly Luiz Tavares , Assunção Nilson Antônio 
Published: June 2024

AbstractBackgroundSchizophrenia (SCZ) is a severe mental disorder of multifactorial origin in which the role of amino acids is relatively unknown. Based on the hypothesis that there is an imbalance in amino acid levels in individuals with SCZ compared with healthy controls (HCs), the aim of this study was to identify the 20 proteinogenic amino acids involved in protein synthesis.MethodsThis study included 43 sex‐ and age‐matched individuals: 20 HCs and 23 with SCZ diagnosed using the Diagnostic and Statistical Manual of Mental Disorders criteria. Using proton nuclear magnetic resonance, we identified the serum levels of the 20 amino acids proteinogenic. We perform multivariate statistical exploratory analyzes to identify compounds, quantify, and identify the main biomarkers of SCZ.ResultsWe identified the serum levels of 19 of the 20 amino acids. Cysteine, the main precursor of glutathione, was not detected. Multivariate exploratory analysis identified lysine, Tryptophan (TRP), and glutamate as possible biomarkers of SCZ. Both lysine and TRP levels were lower and glutamate levels were higher in individuals with SCZ than in HCs. The observed reduction in plasma TRP levels in SCZ was attributed to the activation of the kynurenine pathway and has implications for serotonin synthesis. A strong positive correlation was observed between lysine and TRP, and a weak negative correlation between lysine and glutamate. This result is consistent with the lysine catalysis process because lysine degradation generates glutamate and favors an increase in dopamine.ConclusionsThe results are consistent with the lysine catalysis process because lysine degradation generates glutamate and favors an increase in dopamine. We were unable to identify any studies suggesting a relationship between lysine catabolism and SCZ pathophysiology, but we recognize this association as innovative.
Mitigating against the between‐ensemble‐member precipitation bias in a lagged sub‐seasonal ensemble
Authors: Mittermaier Marion , Kolusu Seshagiri Rao , Robbins Joanne 
Published: June 2024

AbstractThe Met Office GloSea5‐GC2 sub‐seasonal‐to‐seasonal 40‐member lagged ensemble consists of members who are up to 10 days different in age such that the between‐ensemble‐member bias is not internally consistent. Reforecasts tend to be used to convert these ensemble forecasts into anomalies from a normal state. These anomalies are however not that useful for applications where individual ensemble members are needed to drive downstream applications in the hazard and impact space. Here we explore whether there is a way of correcting for the within‐ensemble bias without using reforecasts. An investigation into the individual daily precipitation distributions from the JJAS 2019 Indian monsoon season, stratified by forecast horizon, highlights how the distribution changes, and shows that the model distribution is markedly different to the observed. Initial results suggest that it could be better to use recent model forecast distribution(s) as the reference for adjusting the model rainfall accumulations as a function of lead day horizon, that is, not attempting to correct the members to a vastly different (observed) distribution shape, but a more subtle shift towards the model's best guess of reality, rather than reality itself, to remove the between‐ensemble‐member bias. A combination of Exponential and Generalized Pareto distributions are used for parametric quantile mapping to remove this internal ensemble bias using computationally efficient pre‐computed lookup tables. Within‐ and out‐of‐sample results for the 2019 and 2020 monsoon seasons show that the method is effective in tightening precipitation gradients, with improvements in spread, accuracy and skill, especially for low accumulations.
Beat Pilot Tone (BPT): Simultaneous MRI and RF motion sensing at arbitrary frequencies
Authors: Anand Suma , Lustig Michael 
Published: June 2024

AbstractPurposeTo introduce a simple system exploitation with the potential to turn MRI scanners into general‐purpose radiofrequency (RF) motion monitoring systems.MethodsInspired by Pilot Tone (PT), this work proposes Beat Pilot Tone (BPT), in which two or more RF tones at arbitrary frequencies are transmitted continuously during the scan. These tones create motion‐modulated standing wave patterns that are sensed by the receiver coil array, incidentally mixed by intermodulation in the receiver chain, and digitized simultaneously with the MRI data. BPT can operate at almost any frequency as long as the intermodulation products lie within the bandwidth of the receivers. BPT's mechanism is explained in electromagnetic simulations and validated experimentally.ResultsPhantom and volunteer experiments over a range of transmit frequencies suggest that BPT may offer frequency‐dependent sensitivity to motion. Using a semi‐flexible anterior receiver array, BPT appears to sense cardiac‐induced body vibrations at microwave frequencies (1.2 GHz). At lower frequencies, it exhibits a similar cardiac signal shape to PT, likely due to blood volume changes. Other volunteer experiments with respiratory, bulk, and head motion show that BPT can achieve greater sensitivity to motion than PT and greater separability between motion types. Basic multiple‐input multiple‐output ( MIMO) operation with simultaneous PT and BPT in head motion is demonstrated using two transmit antennas and a 22‐channel head‐neck coil.ConclusionBPT may offer a rich source of motion information that is frequency‐dependent, simultaneous, and complementary to PT and the MRI exam.
Muscle diffusion tensor imaging in facioscapulohumeral muscular dystrophy
Authors: Barzaghi Leonardo , Paoletti Matteo , Monforte Mauro , Bortolani Sara , Bonizzoni Chiara , Thorsten Feiweier , Bergsland Niels , Santini Francesco , Deligianni Xeni , Tasca Giorgio , Ballante Elena , Figini Silvia , Ricci Enzo , Pichiecchio Anna 
Published: June 2024

AbstractIntroduction/AimsMuscle diffusion tensor imaging has not yet been explored in facioscapulohumeral muscular dystrophy (FSHD). We assessed diffusivity parameters in FSHD subjects compared with healthy controls (HCs), with regard to their ability to precede any fat replacement or edema.MethodsFat fraction (FF), water T2 (wT2), mean, radial, axial diffusivity (MD, RD, AD), and fractional anisotropy (FA) of thigh muscles were calculated in 10 FSHD subjects and 15 HCs. All parameters were compared between FSHD and controls, also exploring their gradient along the main axis of the muscle. Diffusivity parameters were tested in a subgroup analysis as predictors of disease involvement in muscle compartments with different degrees of FF and wT2 and were also correlated with clinical severity scores.ResultsWe found that MD, RD, and AD were significantly lower in FSHD subjects than in controls, whereas we failed to find a difference for FA. In contrast, we found a significant positive correlation between FF and FA and a negative correlation between MD, RD, and AD and FF. No correlation was found with wT2. In our subgroup analysis we found that muscle compartments with no significant fat replacement or edema (FF < 10% and wT2 < 41 ms) showed a reduced AD and FA compared with controls. Less involved compartments showed different diffusivity parameters than more involved compartments.DiscussionOur exploratory study was able to demonstrate diffusivity parameter abnormalities even in muscles with no significant fat replacement or edema. Larger cohorts are needed to confirm these preliminary findings.
Mothers' experience of infant massage in child health care: A qualitative interview study
Authors: Danielsson Marlene , Lustig Hanna Hansson , Garmy Pernilla , Einberg Eva‐Lena 
Published: June 2024

AbstractAimTo investigate mothers' experience of infant massage.DesignThis was an exploratory‐descriptive qualitative study based on individual interviews.MethodsA qualitative interview study with an inductive approach was used according to the COREQ guidelines. The participants in the study were mothers (n = 11) residing in Sweden who received training in infant massage from the child health care nurse in the child health care services. The transcribed interviews were analysed using a qualitative content analysis.ResultsThe collected material resulted in two categories and eight subcategories. The categories were learning infant massage and using infant massage as a tool. The eight subcategories were massaging in a parent group, massaging at home, massage movements and the child health care nurse's supporting hand, reading the child's signals, creating time and relaxation together, interaction and connection between the child and the parent, relief from stomach problems and anxiety and continuing to massage the older child.The study showed that mothers experienced that the relationship created through infant massage brought more joy, tenderness and security to the child. The child health care nurse had an important role in supporting the mothers, especially when it came to different views on doing infant massage at home and in groups.Patient or Public ContributionMothers with experience of infant massage were interviewed.