bluuebunny/crossref_metadata_2025_split huggingface dataset:
Acupuncture for hot flashes in hormone receptor‐positive breast cancer: A pooled analysis of individual patient data from parallel randomized trials
Authors: Lu Weidong , Giobbie‐Hurder Anita , Tanasijevic Anna , Kassis Sylvia Baedorf , Park Sung Hwan , Jeong Young Ju , Shin Im Hee , Yao Chang , Jung Hyun Jung , Zhu Zhiyuan , Bao Chao , Bao Ting , Yang EunMee , Bierer Barbara E. , Ligibel Jennifer A. 
Published: June 2024

AbstractBackgroundHot flashes are a common side effect of endocrine therapy (ET) that contribute to poor quality of life and decreased treatment adherence.MethodsPatients with breast cancer wo were receiving ET and experiencing hot flashes were enrolled through three parallel, randomized trials conducted in the United States, China, and South Korea. Participants were randomized to either immediate acupuncture (IA) or delayed acupuncture control (DAC). IA participants received 20 acupuncture sessions over 10 weeks, whereas DAC participants received usual care, then crossed over to acupuncture with a reduced intensity. The primary end point was a change in score on the endocrine symptom subscale of the Functional Assessment of Cancer Therapy (FACT)‐Endocrine Symptoms between baseline and week 10. Secondary end points included the hot flash score and the FACT‐Breast score. A planned pooled analysis of individual patient data was performed using longitudinal mixed models.ResultsIn total, 158 women with stage 0–III breast cancer were randomized (United States, n = 78; China, n = 40; South Korea, n = 40). At week 10, IA participants reported statistically significant improvements in the endocrine symptom subscale score (mean change ± standard error: 5.1 ± 0.9 vs. 0.2 ± 1.0; p = .0003), the hot flash score (−5.3 ± 0.9 vs. −1.4 ± 0.9; p < .003), and the FACT‐Breast total score (8.0 ± 1.6 vs. −0.01 ± 1.6; p = .0005) compared with DAC participants. The effect of the acupuncture intervention differed by site (p = .005).ConclusionsAcupuncture led to statistically and clinically meaningful improvements in hot flashes, endocrine symptoms, and breast cancer‐specific quality of life in women undergoing ET for breast cancer in the United States, China, and South Korea.
Pressure‐Induced Pre‐Lithiation Enables High‐Performing Si Anodes in All‐Solid‐State Batteries
Authors: Hu Weifei , Li Yuanyuan , Liu Jinping 
Published: June 2024

A commentary on pressure‐induced pre‐lithiation towards Si anodes in all‐solid‐state Li‐ion batteries (ASSLIBs) using sulfide electrolytes (SEs) is presented. First, feasible pre‐lithiation technologies for Si anodes in SE‐based ASSLIBs especially the significant pressure‐induced pre‐lithiation strategies are briefly reviewed. Then, a recent achievement by Meng et al. in this field is elaborated in detail. Finally, the significance of Meng's work is discussed.
Closed‐Form Formulae for Variance and Volatility Swaps Under Stochastic Volatility With Stochastic Liquidity Risks
Authors: Lin Sha , He Xin‐Jiang 
Published: June 2024

ABSTRACTWe construct a stochastic volatility model considering stochastic liquidity risks when valuing variance and volatility swaps with discrete sampling. We base our model on Heston stochastic volatility, which is adopted for the modeling of stock prices when the market is perfectly liquid. Stock dynamics are further revised by discounting their prices through the employment of mean reverting market liquidity. We convert the stock dynamics under the physical measure into the one under a risk‐neutral measure via measure transform, with which the analytical valuation of variance and volatility swaps is realized. By taking the limit of sampling frequency, we further consider how both swaps with continuous sampling can be priced. Numerical implementation is finally carried out, with which the capability of the constructed model in capturing the influence of the two common types of financial risks can be clear.
Geography and environment: New conversations, new communities
Authors: Parsons Laurie , Bickerstaff Karen , Darvill Christopher , Yu Le 
Published: June 2024

AbstractIn this Editorial, the Geo: Geography and Environment Editors reflect on the journal over the past year, highlighting some of the key papers published and ‘Geo Themes’ being developed: ‘Decolonising Climate Geography’; ‘Climate Change, AI and Sustainability’; ‘Geographies of Energy Futures’. The Editors renew the call for submissions on these topics and put out a new call for Special Section proposals on subjects around the environment, climate and sustainability.
Effect of alternative and complementary medicine on male infertility: An umbrella review
Authors: Fasanghari Maryam , Keramat Afsaneh , Tansaz Mojgan , Moini Ashraf , Chaman Reza 
Published: June 2024

AbstractBackground and AimsThere is increasing interest worldwide in using alternative and complementary approaches for treating male infertility. This interest has spawned a multitude of published systematic reviews and meta‐analyses. The aim of this Umbrella review was to consolidate the available evidence regarding the effect of complementary and alternative medicine on male infertility to inform clinical decision‐making processes.MethodsA comprehensive search was conducted to identify systematic reviews and meta‐analyses pertaining to the effects of complementary and alternative medicine on male infertility. This search encompassed various databases including MEDLINE, CINAHL, PubMed, Scopus, Proquest, Google Scholar, SID, EMBASE, Magiran, Cochrane Library, Iranmedex, ScienceDirect, SAGE. Subsequently, two researchers independently extracted the data from the selected meta‐analyses and systematic reviews, and evaluated their methodological quality using the assessment of multiple systematic reviews 2 (AMSTAR2).ResultsThis analysis encompassed 11 studies, with four originating from Iran, two from Korea and five from China. The results regarding the effectiveness of complementary and alternative medicine are controversial, indicating a need for further research. The methodological quality of the systematic reviews and meta‐analyses appraised by AMSTAR 2 was rated as low or critically low. This assessment is attributed to inadequate examination of publication biases in the reviews and a lack of discussion regarding the effect of risk of bias.ConclusionThe existing evidence regarding the effectiveness of alternative and complementary medicine in addressing male infertility is limited. Furthermore, the overall methodological quality of the published systematic reviews and meta‐analyses may have been underestimated as the use of AMSTAR2 appears to be a more precise appraisal instrument compared to its predecessor.
A nurse driven care management program to engage older diabetes patients in personalized goal setting and disease management
Authors: Zhu Mengqi , Cui Michael , Nathan Aviva G. , Press Valerie G. , Wan Wen , Miles Cristy , Ali Rabia , Pusinelli Mariko , Huisingh‐Scheetz Megan , Huang Elbert S. 
Published: June 2024

AbstractBackground and AimsMultiple diabetes care guidelines have called for the personalization of risk factor goals, medication management, and self‐care plans among older patients. Study of the implementation of these recommendations is needed. This study aimed to test whether a patient survey embedded in the Electronic Healthcare Record (EHR), coupled with telephonic nurse care management, could engage patients in personalized goal setting and chronic disease management.MethodsWe conducted a single‐center equal‐randomization delayed comparator trial at the primary care clinics of the University of Chicago Medicine from 2018.6 to 2019.12. Patients over the age of 65 years with type 2 diabetes with an active patient portal account were recruited and randomized to receive an EHR embedded goal setting and preference survey immediately in the intervention arm or after 6 months in the delayed intervention control arm. In the intervention arm, nurses reviewed American Diabetes Association recommendations for A1C goals based on health status class, established personalized goals, and provided monthly telephonic care management phone calls for a maximum of 6 months. Our primary outcome was the documentation of a personalized A1C goal in the EHR.ResultsA total of 100 patients completed the trial (mean age, 72.51 [SD, 5.22] years; mean baseline A1C, 7.14% [SD, 1.06%]; 68% women). The majority were in the Healthy (59%) followed by Complex (30%) and Very Complex (11%) health status classes. Documentation of an A1C goal in the EHR increased from 42% to 90% (p < 0.001) at 6 months in the intervention group and from 54% to 56% in the control group. Across health status classes, patients set similar A1C goals.ConclusionsOlder patients can be engaged in personalized goal setting and disease management through an embedded EHR intervention. The clinical impact of the intervention may differ if deployed among older patients with more complex health needs and higher glucose levels.Trial RegistrationClinicalTrials.gov Identifier: NCT03692208.
Building literacy connections after disaster: Teacher candidates engaging with community through a service‐learning lens
Authors: Hulan Nancy Franklin , Bailey‐Tarbett Leslee K. 
Published: June 2024

AbstractThis study examines the experiences of 17 teacher candidates who participated in a literacy‐focused service‐learning initiative in the aftermath of destructive tornadoes in their community. In response to the natural disaster, the Literacy Ambassadors, composed of university literacy faculty and teacher candidates, sought to address the critical need for book access among area students impacted by the tornadoes. Over the course of 8 months, researchers collected initial questionnaires, participant reflections, meeting transcripts, and anecdotal notes as the group met to learn about book matching, text complexity, and to acquire, sort, and curate book bags for individual preK‐12 students. Books were shared with community members on three occasions—two occurred 12 months after the tornadoes and served eight schools; another occurred 16 months after the event and served one school. Participants revealed themes of shifting identity, a developing understanding of the complexity of literacy, and the relational power of literacy—offering valuable insights into the impact of community engagement on teacher candidates in response to disaster. These findings support previous research that emphasizes the potential of service‐learning as real‐life experiences that address community needs while simultaneously enriching the professional growth of future educators.
The seeds of change: Antecedent variables and their impact in building grit and resilience through outdoor adventure education
Authors: Davidson Curt , Foster Stephen 
Published: June 2024

AbstractIntroductionThis study examines the impact of Outdoor Adventure Education (OAE) on developing grit and resilience in adolescents. Focusing on a United States‐based sample collected in 2015, it explores how antecedent variables such as age and gender influence these outcomes, integrating the PERMA model of well‐being to investigate underlying mechanisms.MethodsThe research employed a cross‐sectional design with 350 participants aged 14–18 from various OAE courses. Data collection involved pre/post surveys assessing grit and resilience as experiences through mastery, relatedness, and emotional reactivity. The study utilized established inventories for grit and the Resilience Scales for Children and Adolescents.ResultsFindings revealed significant grit, mastery, and relatedness increases following the OAE program. Participants demonstrated enhanced perseverance and passion toward goals, increased sense of mastery, and better relational dynamics. However, emotional reactivity scores remained largely unchanged. Notably, the impact of these programs varied based on participants' gender and socioeconomic status, indicating differential effects across demographic groups.ConclusionsThe study suggests that OAE programs effectively foster grit and resilience in adolescents, with varying impacts based on demographic factors. It highlights the necessity for inclusive and adaptive program designs that cater to diverse participant needs. The results contribute valuable insights to the field of youth development, emphasizing the role of OAE in enhancing key psychological traits essential for adolescents' growth and adaptation.
Effects of nanomodified titanium surfaces considering bacterial colonization and viability of osteoblasts and fibroblasts
Authors: Astasov‐Frauenhoffer Monika , Marot Laurent , Sanchez Fabien , Steiner Roland , Lohberger Birgit , Bornstein Michael M. , Wagner Raphael S. , Kühl Sebastian , Mukaddam Khaled 
Published: June 2024

AbstractThis study investigates nanostructured titanium surfaces (Ti2 spikes) that promote the viability of osteoblasts and fibroblasts and prevent bacterial colonisation. Helium ion irradiation was adopted to produce nanometric‐sized cones on titanium. Human osteoblasts (hFOB) and human gingiva fibroblasts (hGF) were used for analysis. A viability and a cytotoxicity assay were conducted to evaluate the lactate dehydrogenase (LDH) activity and assess cell damage in Ti2 spikes compared to titanium discs with a sandblasted and acid‐etched (Ti2 SLA) surface. The antibacterial activity was investigated against Escherichia coli, Streptococcus mutans, Fusobacterium nucleatum, and Porphyromonas gingivalis. In the course of the cultivation, both hGF and hFOB demonstrated significantly reduced viability on the Ti2 spikes surface. hGF cells exhibited a slight but significant increase in LDH release. In contrast, hFOB showed reduced cytotoxicity on this surface. On the Ti2 spikes surface, hGF cells exhibited a significant reduction in gene expression of VCL, Src‐1, and ITGα5. However, the integrin subunits ITGα1 and ITGα3 showed upregulation on the Ti2 spikes surface. The Ti2 spikes surface significantly increased the expression of almost all osteogenic markers. The results of conventional culturing demonstrated a statistically significant decrease in the number of viable cells for S. mutans, F. nucleaum, and greater quantities of P. gingivalis on Ti2 spikes surface compared to control. However, no such reduction was detected for E. coli. The long‐term success of implants relies on establishing and maintaining hard and soft peri‐implant tissues. Ti2 spikes represent a novel and promising approach to enhance osseointegration and optimize biocompatibility.
Predictors of outcome in self‐guided internet‐delivered cognitive‐behavior therapy for obsessive‐compulsive disorder: A preliminary investigation
Authors: Wootton Bethany M. , McDonald Sarah , Karin Eyal , Titov Nickolai , Dear Blake F. 
Published: June 2024

AbstractInternet‐delivered cognitive‐behavioral therapy (ICBT) is an effective treatment for obsessive‐compulsive disorder (OCD). ICBT can be delivered in a self‐guided or clinician‐guided format. While a literature is emerging on the predictors of response to clinician‐guided ICBT, there is a lack of research examining the predictors of response to self‐guided ICBT. The aim of the present study was to examine predictors of outcome in a large sample of participants with OCD who commenced a self‐guided ICBT intervention. One hundred and fifty‐seven participants (Mage = 34.82; SD = 10.49; 78% female) were included in the study. Regression analyses were conducted to determine clinical and demographic predictors of (1) posttreatment symptom severity and (2) a clinically meaningful treatment response for both the intention‐to‐treat (ITT) and completer samples. The regression models significantly predicted posttreatment outcome for both the ITT (F(8, 148) = 15.844, p < .001) and completer sample (F(8, 101) = 5.929, p < .001), explaining 46% and 34% of the variance respectively. Higher baseline OCD severity, younger age, experiencing higher contamination or symmetry symptoms, and a history of past treatment were all found to be significantly associated with higher posttreatment severity in the ITT sample. In the completer sample only higher baseline OCD severity and severity of harm‐related obsessions and checking compulsions was significantly associated with higher posttreatment severity. When predicting treatment response the regression models for both the ITT and completer sample were nonsignificant.
Time tracking and comparison of genetic counseling tasks in inpatient and outpatient settings
Authors: Osborne Alexandra , Bland Emily Magness , Diamonstein Callie , Fishler Kristen 
Published: June 2024

AbstractGenetic counselors (GCs) practice in critical care settings. Some GCs have full‐time inpatient roles, while most GCs who see inpatients do so as needed or on a rotating schedule in addition to seeing patients in an outpatient setting. Few studies have tracked and compared the amount of time it takes GCs to perform tasks in the inpatient and outpatient settings. Genetic counselors were invited to participate in this study via the National Society of Genetic Counselors research listserv. Participants completed an online survey asking how their role is structured and what types of support are available to them while seeing inpatients. They also performed time tracking for 16 tasks known to be associated with inpatient and/or outpatient care via RedCap. These tasks include direct patient care, care coordination, and other tasks which encapsulate a new patient encounter from beginning to end. Forty‐two inpatient encounters and 26 outpatient encounters were analyzed. The total average time spent on an inpatient consult (3 h and 38.5 min) was significantly higher than the time spent on an outpatient consult (2 h and 24.7 min; p < 0.05). Individually, genetic counselors spent significantly more time on the following tasks in an inpatient setting: direct follow‐up encounters, multidisciplinary team communication, results disclosure encounters, results disclosure documentation, traveling, and waiting. Follow‐up encounters, traveling, and waiting happen almost exclusively in inpatient settings. Short answer prompts regarding structure of GC role and available support revealed themes including lack of inpatient role structure, challenges with balancing between inpatient and outpatient tasks, and varied institutional support. These results promote further discussion about how to support GCs who see inpatients as these roles expand. Some suggestions include increased FTE/protected time and/or GCA support specific to the inpatient role.
Attainable bounds for algebraic connectivity and maximally connected regular graphs
Authors: Exoo Geoffrey , Kolokolnikov Theodore , Janssen Jeanette , Salamon Timothy 
Published: June 2024

AbstractWe derive attainable upper bounds on the algebraic connectivity (spectral gap) of a regular graph in terms of its diameter and girth. This bound agrees with the well‐known Alon–Boppana–Friedman bound for graphs of even diameter, but is an improvement for graphs of odd diameter. For the girth bound, we show that only Moore graphs can attain it, and these only exist for well‐known special cases. For the diameter bound, we use a combination of stochastic algorithms and exhaustive search to find graphs which attain it. For 3‐regular graphs, we find attainable graphs for all diameters up to and including (the case of is open). These graphs are extremely rare and also have high girth; for example, we found exactly 45 distinct cubic graphs on 44 vertices attaining the upper bound when ; all have girth 8. We also exhibit several infinite families attaining the upper bound with respect to diameter or girth. In particular, when is a power of prime, we construct a ‐regular graph having diameter 4 and girth 6 which attains the upper bound with respect to diameter.
Purification, Characterization, and Assessment of Anticancer Activity of Iron Oxide Nanoparticles Biosynthesized by Novel Thermophilic Bacillus tequilensis ASFS1‏
Authors: Satarzadeh Naghmeh , Shakibaie Mojtaba , Forootanfar Hamid , Amirheidari Bagher 
Published: June 2024

ABSTRACTMagnetic nanoparticles (MNPs), particularly iron oxide nanoparticles (IONPs), are a fascinating group of nanoparticles that have been considerably investigated for biomedical applications because of their superparamagnetic properties, biodegradable nature, and biocompatibility. A novel Gram‐positive moderately thermophilic bacterial strain, namely Bacillus tequilensis ASFS.1, was isolated and identified. This strain is capable of producing superparamagnetic Fe3O4 nanoparticles and exhibiting magnetotaxis behavior. This strain swimming behavior was investigated under static and dynamic environments, where it behaved very much similar to the magnetotaxis in magnetotactic bacteria. This study is the first report of a bacterium from the Bacillaceae family that has the potential to intracellular biosynthesis of IONPs. MNPs were separated by a magnetic and reproducible method which was designed for the first time for this study. In addition, UV‐visible spectrophotometer, Fourier‐transform infrared spectroscopy, vibrating sample magnetometer, field emission scanning electron microscopy (FESEM), X‐ray diffraction, and thermal gravimetric analysis were utilized to characterize the bio‐fabricated magnetite nanoparticles. Analysis of the particle size distribution pattern of the biogenic MNPs by FESEM imaging revealed the size range of 10–100 nm with the size range of 10–40 nm MNPs being the most frequent particles. VSM analysis demonstrated that biogenic MNPs displayed superparamagnetic properties with a high saturation magnetization value of 184 emu/g. After 24 h treatment of 3T3, U87, A549, MCF‐7, and HT‐29 cell lines with the biogenic MNPs, IC50 values were measured to be 339, 641, 582, 149, and 184 μg mL−1, respectively. This study presents the novel strain ASFS.1 capable of magnetotaxis by the aid of its magnetite nanoparticles and paving information on isolation, characterization, and in vitro cytotoxicity of its MNPs. The MNPs showed promising potential for biomedical applications, obviously subject to additional studies.
Growth patterns in infants born to women with pregestational overweight/obesity supplemented with docosahexaenoic acid during pregnancy
Authors: De Toro Valeria , Alberti Gigliola , Dominguez Angelica , Carrasco‐Negüe Karina , Ferrer Pedro , Valenzuela Rodrigo , Garmendia Maria Luisa , Casanello Paola 
Published: June 2024

AbstractBackgroundPrevious studies of maternal docosahexaenoic acid (DHA) supplementation during pregnancy have controversial and contrasting results on the short and long‐term effects on early child growth. The impact of this nutritional intervention on the postnatal growth patterns in the offspring of women with pregestational overweight/obesity (PGO) also remains controversial.ObjectiveTo analyze the postnatal growth patterns during the first 4 months of life in the offspring of women with PGO randomly supplemented with 800 mg/day (PGO‐800) compared with normative doses of 200 mg/day (PGO‐200) of DHA during pregnancy (<15 weeks of gestation until delivery).MethodsThis study evaluated the growth patterns during the first 4 months of life of 169 infants of the women that participated in the MIGHT study (NCT02574767). We included the infants of women from the PGO‐200 (n = 81) and PGO‐800 group (n = 88). The growth patterns (weight, length, and head circumference) and change in z‐score (World health Organization charts) were evaluated.ResultsThroughout the first 4 months of life, the infants of the PGO‐800 group had lower weight‐for‐length z‐score (coef. −0.65, 95% confidence interval [CI] −1.07, −0.22, p = 0.003) and lower body mass index‐for‐age z‐score (coef. −0.56, 95% CI −0.99, −0.12, p = 0.012) compared with the PGO‐200 group adjusted by maternal body mass index, gestational weight gain, gestational age, insulin in cord blood and infant feeding (exclusive breastfed, not breastfed, and partially breastfed).ConclusionsMaternal supplementation with DHA during pregnancy could beneficially limit the offspring's postnatal weight gain during the first 4 months of life.