bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Surface Radiation Budget over Oceans and Continents
Authors: Garratt J. R. , Prata A. J. , Rotstayn L. D. , McAvaney B. J. , Cusack S. 
Published: March 2011

Abstract
An updated evaluation of the surface radiation budget in climate models (1994–96 versions; seven datasets available, with and without aerosols) and in two new satellite-based global datasets (with aerosols) is presented. All nine datasets capture the broad mean monthly zonal variations in the flux components and in the net radiation, with maximum differences of some 100 W m−2 occurring in the downwelling fluxes at specific latitudes. Using long-term surface observations, both from land stations and the Pacific warm pool (with typical uncertainties in the annual values varying between ±5 and 20 W m−2), excess net radiation (RN) and downwelling shortwave flux density (So↓) are found in all datasets, consistent with results from earlier studies [for global land, excesses of 15%–20% (12 W m−2) in RN and about 12% (20 W m−2) in So↓]. For the nine datasets combined, the spread in annual fluxes is significant: for RN, it is 15 (50) W m−2 over global land (Pacific warm pool) in an observed annual mean of 65 (135) W m−2; for So↓, it is 25 (60) W m−2 over land (warm pool) in an annual mean of 176 (197) W m−2.
The effects of aerosols are included in three of the authors’ datasets, based on simple aerosol climatologies and assumptions regarding aerosol optical properties. They offer guidance on the broad impact of aerosols on climate, suggesting that the inclusion of aerosols in models would reduce the annual So↓ by 15–20 W m−2 over land and 5–10 W m−2 over the oceans. Model differences in cloud cover contribute to differences in So↓ between datasets; for global land, this is most clearly demonstrated through the effects of cloud cover on the surface shortwave cloud forcing. The tendency for most datasets to underestimate cloudiness, particularly over global land, and possibly to underestimate atmospheric water vapor absorption, probably contributes to the excess downwelling shortwave flux at the surface.
CAPE Variations in the Current Climate and in a Climate Change
Authors: Ye Bing , Del Genio Anthony D. , Lo Kenneth K-W. 
Published: March 2011

Abstract
Observed variations of convective available potential energy (CAPE) in the current climate provide one useful test of the performance of cumulus parameterizations used in general circulation models (GCMs). It is found that frequency distributions of tropical Pacific CAPE, as well as the dependence of CAPE on surface wet-bulb potential temperature (Θw) simulated by the Goddard Institute for Space Studies’s GCM, agree well with that observed during the Australian Monsoon Experiment period. CAPE variability in the current climate greatly overestimates climatic changes in basinwide CAPE in the tropical Pacific in response to a 2°C increase in sea surface temperature (SST) in the GCM because of the different physics involved. In the current climate, CAPE variations in space and time are dominated by regional changes in boundary layer temperature and moisture, which in turn are controlled by SST patterns and large-scale motions. Geographical thermodynamic structure variations in the middle and upper troposphere are smaller because of the canceling effects of adiabatic cooling and subsidence warming in the rising and sinking branches of the Walker and Hadley circulations. In a forced equilibrium global climate change, temperature change is fairly well constrained by the change in the moist adiabatic lapse rate and thus the upper troposphere warms to a greater extent than the surface. For this reason, climate change in CAPE is better predicted by assuming that relative humidity remains constant and that the temperature changes according to the moist adiabatic lapse rate change of a parcel with 80% relative humidity lifted from the surface. The moist adiabatic assumption is not symmetrically applicable to a warmer and colder climate: In a warmer regime moist convection determines the tropical temperature structure, but when the climate becomes colder the effect of moist convection diminishes and the large-scale dynamics and radiative processes become relatively important. Although a prediction based on the change in moist adiabat matches the GCM simulation of climate change averaged over the tropical Pacific basin, it does not match the simulation regionally because small changes in the general circulation change the local boundary layer relative humidity by 1%–2%. Thus, the prediction of regional climate change in CAPE is also dependent on subtle changes in the dynamics.
Means and Trends of Shortwave Irradiance at the Surface Estimated from Global Energy Balance Archive Data
Authors: Gilgen H. , Wild M. , Ohmura A. 
Published: March 2011

Abstract
Means and trends of shortwave irradiance at the earth’s surface are calculated from pyranometer measurements stored in the Global Energy Balance Archive (GEBA) database. The GEBA database contains the most comprehensive set of shortwave irradiance monthly means. The relative random error of measurement is approximately 5% of a monthly mean in general and approximately 2% of a yearly mean. The shortwave irradiance yearly means are analyzed in a 2.5° × 2.5° grid. In average example grid cells in Europe (no large altitude differences, no coasts), the difference of shortwave irradiance yearly means measured at different stations (station effect) is less than 5% of the cell mean, and the interannual variability is approximately 4% of the cell mean. On most continents, shortwave irradiance decreases significantly in large regions, and significant positive trends are observed only in four small regions.
The 1995 and 1996 North Atlantic Hurricane Seasons: A Return of the Tropical-Only Hurricane
Authors: Kimberlain Todd B. , Elsner James B. 
Published: March 2011

Abstract
Hurricane activity over the North Atlantic basin during 1995 and 1996 is compared to the combined hurricane activity over the previous four years (1991–94). The earlier period produced a total of 15 hurricanes compared to a total of 20 hurricanes over the latter period. Despite this similarity in numbers, the hurricanes of 1995 and 1996 were generally of the tropical-only variety, which marks a substantial departure from activity during the early 1990s. The return of tropical-only hurricanes to the Atlantic basin is likely the result of several global and local factors, including cool SST conditions in the equatorial central and eastern Pacific and warm SSTs in the tropical Atlantic. The hurricane activity of 1995 and 1996 is more reminiscent of activity of some seasons during the early and mid-1950s.
Changes in the Number of Lightning Deaths in the United States during the Twentieth Century
Authors: López Raúl E. , Holle Ronald L. 
Published: March 2011

Abstract
Long-term changes in the number of lightning deaths from 1900 to 1991 have been examined for the contiguous United States. The population-normalized series revealed an exponential decrease in the number of deaths per million people. This exponential trend is also present in the decrease of the rural U.S. population for the period. The two datasets agree remarkably well and this suggests the downward trend in lightning deaths resulted to a large extent from the reduction of the rural population.
Superimposed on the overall downward trend in lightning deaths were fluctuations of two or three decades in duration. The patterns of these fluctuations are paralleled by nationwide changes in thunder-day frequencies and average surface temperature values. Thus, it appears that the lightning death fluctuations are climatically induced.
Response of Climate Simulation to a New Convective Parameterization in the National Center for Atmospheric Research Community Climate Model (CCM3)*
Authors: Zhang Guang J. , Kiehl Jeffrey T. , Rasch Philip J. 
Published: March 2011

AbstractThis study examines the response of the climate simulation by the National Center for Atmospheric Research Community Climate Model (CCM3) to the introduction of the Zhang and McFarlane convective parameterization in the model. It is shown that in the CCM3 the simulated surface climate in the tropical convective regimes, especially in the western Pacific warm pool, is markedly improved, yielding a much better agreement with the recent observations. The systematic bias in the surface evaporation, surface wind stress over the tropical Pacific Ocean in previous model simulations is significantly reduced, owing to the better simulation of the surface flow.Experiments using identical initial and boundary conditions, but different convection schemes, are performed to isolate the role of the convection schemes and to understand the interaction between convection and the large-scale circulation in a convecting atmosphere. The comparison of the results from these experiments in the western Pacific warm pool suggests that use of the Zhang and McFarlane scheme makes a significant contribution to the improved climate simulation in CCM3. The simulated atmosphere using the Zhang and McFarlane scheme exhibits a quasi-equilibrium between convection and the large-scale processes. When this scheme is removed from the CCM3, such a quasi-equilibrium is no longer observed. In addition, the simulated thermodynamic structures, the surface evaporation, and surface winds in the Pacific warm pool become very similar to those in the CCM2 climate.Examination of the temporal evolution of the various fields demonstrates that the stabilization of the atmosphere using the new convection scheme takes place during the transition from nonequilibrium to quasi equilibrium at the beginning of the time integration. After quasi equilibrium is reached, the atmosphere is warmer and more stable compared to the run without the new scheme. Associated with the more stable stratification, the atmospheric circulation becomes weaker, thus the surface winds and evaporation are weaker because of the coupling between thermodynamics and dynamics in the tropical troposphere.
Coupled Modes of the Warm Pool Climate System. Part I: The Role of Air–Sea Interaction in Maintaining Madden–Julian Oscillation
Authors: Wang Bin , Xie Xiaosu 
Published: March 2011

Abstract
Over the warm pool of the equatorial Indian and western Pacific Oceans, both the climatological mean state and the processes of atmosphere–ocean interaction differ fundamentally from their counterparts over the cold tongue of the equatorial eastern Pacific. A model suitable for studying the coupled instability in both the warm pool and cold tongue regimes is advanced. The model emphasizes ocean mixed layer physics and thermodynamical coupling that are essential for the warm pool regime. Different coupled unstable modes are found under each regime.
In contrast to the cold tongue basic state, which favors coupled unstable low-frequency SST mode, the warm pool regime (moderate mean surface westerlies and deep thermocline) is conducive for high-frequency (intraseasonal timescale) coupled unstable modes. The wind–mixed layer interaction through entrainment/evaporation plays a central role in the warm pool instability. The cloud-radiation feedback enhances the instability, whereas the ocean wave dynamics have little impact. The thermodynamic coupling between the atmosphere and ocean mixed layer results in a positive SST anomaly leading convection, which provides eddy available potential energy for growing coupled mode. The relatively slow mixed layer response to atmospheric forcing favors the growth of planetary-scale coupled modes. The presence of mean westerlies suppresses the low-frequency SST mode.
The characteristics of the eastward-propagating coupled mode of the warm pool system compares favorably with the large-scale features of the observed Madden–Julian Oscillation (MJO). This suggests that, in addition to atmospheric internal dynamic instability, the ocean mixed layer thermodynamic processes interacting with the atmosphere may play an active part in sustaining the MJO by (a) destabilizing atmospheric moist Kelvin waves, (b) providing a longwave selection mechanism, and (c) slowing down phase propagation and setting up the 40–50-day timescale.
A Pilot Study Examining U.S. Winter Cyclone Frequency Patterns Associated with Three ENSO Parameters
Authors: Noel James , Changnon David 
Published: March 2011

Abstract
Teleconnections were used to link three El Niño–Southern Oscillation (ENSO) parameters to winter (December–February) cyclone frequencies over the United States during the 1949–96 period. Since each ENSO event is not exactly the same, small subsets of ENSO events were examined in addition to the more common composite ENSO event. Mean winter cyclone frequencies, derived by counting cyclones passing through 30, 5° latitude equal-area circles located in a grid from 70° to 120°W and 30° to 50°N were determined for classes of El Niños and La Niñas based on 1) the intensity of the equatorial Pacific sea surface temperature anomaly, 2) the intensity of the Tahiti–Darwin sea level pressure anomaly, and 3) the location of the 28°C isotherm. The average cyclone count for each class of El Niño and La Niña was compared to the average count for winters when no ENSO event occurred.
Expected differences in cyclone frequency patterns when comparing an average of all El Niño winters to all La Niña winters were found; however, large pattern differences were also determined when comparing winters with strong El Niños to moderate–weak El Niños and similarly for La Niñas. Significant differences in number of cyclones were found in 8 of 30 circles located in the Pacific Northwest, the Great Lakes, New England, and the Southeast. The differences found in the cyclone frequency patterns for El Niños and La Niñas of different intensities and locations indicated that using a composite of all El Niños or La Niñas may provide misleading information while examination of each of these parameters independently may assist in the preparation of long-range climate predictions.
Changes in renal vessels following the long-term administration of an angiotensin II receptor blocker in Zucker fatty rats
Authors: Nakanishi Kazushige , Nagai Yohko , Honglan Piao  , Akimoto Tatsuo , Kato Hirohito , Yanakieva-Georgieva Nadezhda , Ishikawa Yukio , Yoshihara Kastunori , Ito Kinji , Yamanaka Nobuaki , Oite Takashi 
Published: March 2011

Introduction: The nephro-protective effects of angiotensin II receptor blockers (ARBs) are widely known; however, there are few reports of long-term effects focusing on the renal vessels. We studied afferent arteriolar changes induced by the long-term administration of an ARB. Materials and Methods: Thirty-two 6-week-old male Zucker fatty rats (ZFRs) were divided into following four groups ( n = 8 in each): ZFR Group and ZFR+High Group fed a standard or high-salt diet, respectively; ZFR+ARB Group and ZFR+High+ARB Group fed a standard or high-salt diet with ARB (Olmesartan, 5 mg/kg/day), respectively. Blood pressure, proteinuria, morphological examinations and glomerular haemodynamics in vivo were studied. Results: Marked proliferative changes in the afferent arteriolar smooth muscle cells (SMCs) were frequently observed in the two groups given ARBs; in the ZFR+ARB group (77.3±10.3%) compared with the two groups without ARB (1.7%, p < 0.005; 1.2%, p < 0.0005) and 37.4±15.6% in the ZFR+High+ARB group. Proteinuria markedly decreased in the groups treated with ARBs, but the glomerular erythrocyte velocities showed no differences. Conclusions: Our findings indicate that long-term ARB administration induced unusual proliferative changes in SMCs of afferent arterioles of ZFRs. These changes could narrow arteriolar lumens and reduce intraglomerular pressure, but they could cause also irreversible damage to the arterioles.
Silencing of c-Fos expression by microRNA-155 is critical for dendritic cell maturation and function
Authors: Dunand-Sauthier Isabelle , Santiago-Raber Marie-Laure , Capponi Leonardo , Vejnar Charles E. , Schaad Olivier , Irla Magali , Seguín-Estévez Queralt , Descombes Patrick , Zdobnov Evgeny M. , Acha-Orbea Hans , Reith Walter 
Published: March 2011

Abstract
MicroRNAs (miRNAs) are small, noncoding RNAs that regulate target mRNAs by binding to their 3′ untranslated regions. There is growing evidence that microRNA-155 (miR155) modulates gene expression in various cell types of the immune system and is a prominent player in the regulation of innate and adaptive immune responses. To define the role of miR155 in dendritic cells (DCs) we performed a detailed analysis of its expression and function in human and mouse DCs. A strong increase in miR155 expression was found to be a general and evolutionarily conserved feature associated with the activation of DCs by diverse maturation stimuli in all DC subtypes tested. Analysis of miR155-deficient DCs demonstrated that miR155 induction is required for efficient DC maturation and is critical for the ability of DCs to promote antigen-specific T-cell activation. Expression-profiling studies performed with miR155−/− DCs and DCs overexpressing miR155, combined with functional assays, revealed that the mRNA encoding the transcription factor c-Fos is a direct target of miR155. Finally, all of the phenotypic and functional defects exhibited by miR155−/− DCs could be reproduced by deregulated c-Fos expression. These results indicate that silencing of c-Fos expression by miR155 is a conserved process that is required for DC maturation and function.
Monocytes control natural killer cell differentiation to effector phenotypes
Authors: Soderquest Katrina , Powell Nick , Luci Carmelo , van Rooijen Nico , Hidalgo Andrés , Geissmann Frederic , Walzer Thierry , Lord Graham M. , Martín-Fontecha Alfonso 
Published: March 2011

Abstract
Natural killer (NK) cells play a major role in immunologic surveillance of cancer. Whether NK-cell subsets have specific roles during antitumor responses and what the signals are that drive their terminal maturation remain unclear. Using an in vivo model of tumor immunity, we show here that CD11bhiCD27low NK cells migrate to the tumor site to reject major histocompatibility complex class I negative tumors, a response that is severely impaired in Txb21−/− mice. The phenotypical analysis of Txb21-deficient mice shows that, in the absence of Txb21, NK-cell differentiation is arrested specifically at the CD11bhiCD27hi stage, resulting in the complete absence of terminally differentiated CD11bhiCD27low NK cells. Adoptive transfer experiments and radiation bone marrow chimera reveal that a Txb21+/+ environment rescues the CD11bhiCD27hi to CD11bhiCD27low transition of Txb21−/− NK cells. Furthermore, in vivo depletion of myeloid cells and in vitro coculture experiments demonstrate that spleen monocytes mediate the terminal differentiation of peripheral NK cells in a Txb21- and IL-15Rα–dependent manner. Together, these data reveal a novel, unrecognized role for Txb21 expression in monocytes in promoting NK-cell development and help appreciate how various NK-cell subsets are generated and participate in antitumor immunity.
Bone marrow histopathology in POEMS syndrome: a distinctive combination of plasma cell, lymphoid, and myeloid findings in 87 patients
Authors: Dao Linda N. , Hanson Curtis A. , Dispenzieri Angela , Morice William G. , Kurtin Paul J. , Hoyer James D. 
Published: March 2011

Abstract
POEMS is an uncommon syndromic disorder characterized by polyneuropathy, organomegaly, endocrinopathy, monoclonal protein, and skin changes. There are few descriptions of the bone marrow pathology of POEMS; therefore, peripheral blood smears and bone marrow aspirates and biopsies from 87 patients (143 total, 67 pretreatment, 76 posttreatment cases) with POEMS were studied. Plasma cell clonality was analyzed by flow cytometry, immunohistochemistry, and/or in situ hybridization. Monotypic plasma cells were detected in 44 pretreatment cases (66%); the majority of plasma cells expressed λ light chain (91%). The monotypic plasma cells typically were present in a background of increased polytypic plasma cells. Lymphoid aggregates were found in 33 (49%) pretreatment cases and in most cases were rimmed by plasma cells (97%). Megakaryocyte hyperplasia (36 cases) and clusters (62 cases) were frequent; however, none of the 43 cases tested had the JAK2V617F mutation. In summary, we have identified a novel constellation of features that should strongly suggest POEMS syndrome as part of the differential diagnosis. The constellation of λ-restricted monoclonal gammopathy, plasma cell rimming around lymphoid aggregates, and megakaryocytic hyperplasia in a bone marrow is highly suggestive of this diagnosis, especially in the context of a peripheral neuropathy.
The dynamic influence of the DRB1*1101 allele on the resistance of sheep to experimental Teladorsagia circumcincta infection
Authors: Hassan Musa , Good Barbara , Hanrahan James P , Campion Deirdre , Sayers Gearoid , Mulcahy Grace , Sweeney Torres 
Published: March 2011

AbstractSuffolk sheep carrying theDRB1*1101(previously referred to as-DRB1*0203or G2) allele have been reported to show increased resistance to naturalTeladorsagia circumcinctainfection compared to non-carriers. The objective of this study was to compare the biochemical and physiological responses ofDRB1*1101carrier and non-carrier twin lambs to an experimental infection with 3 × 104L3Teladorsagia circumcincta. The variables studied included worm burden, faecal egg count, abomasal mast cells, IgA, IgE, IgG1 plus IgG2 and haematological parameters at 0, 3, 7, 21 and 35 days post infection (dpi), and duodenal smooth muscle contractility at 0 and 35 dpi.DRB1*1101carrier lambs had significantly lower worm burden, higher mast cell and plasma platelet counts than theDRB1*1101non-carriers (P< 0.05). Before infection, the non-carrier lambs exhibited significantly higher mucosal levels of all antibody isotypes measured compared to the carriers; these levels remained relatively stable over the course of infection in the non-carriers while there was a slow build up of these antibodies in the carriers up to day 21 post infection (pi). TheDRB1*1101non-carrier lambs had a significantly higher plasma lymphocyte count, and produced greater duodenal contractile force relative to the carrier lambs (P< 0.05). There was no significant difference between genotypes in the level of plasma eosinophils, monocytes, neutrophils or FEC. This evidence suggests that resistance conferred byDRB1*1101is acquired rather than innate, depends on worm expulsion rather than fecundity and is dependent on mucosal mast cell proliferation, platelet activation, and IgA and IgE antibody responses.
Vascular disrupting agent DMXAA enhances the antitumor effects generated by therapeutic HPV DNA vaccines
Authors: Peng Shiwen , Monie Archana , Pang Xiaowu , Hung Chien-Fu , Wu T-C 
Published: March 2011

Abstract
Antigen-specific immunotherapy using DNA vaccines has emerged as an attractive approach for the control of tumors. Another novel cancer therapy involves the employment of the vascular disrupting agent, 5,6-dimethylxanthenone-4-acetic acid (DMXAA). In the current study, we aimed to test the combination of DMXAA treatment with human papillomavirus type 16 (HPV-16) E7 DNA vaccination to enhance the antitumor effects and E7-specific CD8+ T cell immune responses in treated mice. We determined that treatment with DMXAA generates significant therapeutic effects against TC-1 tumors but does not enhance the antigen-specific immune responses in tumor bearing mice. We then found that combination of DMXAA treatment with E7 DNA vaccination generates potent antitumor effects and E7-specific CD8+ T cell immune responses in the splenocytes of tumor bearing mice. Furthermore, the DMXAA-mediated enhancement or suppression of E7-specific CD8+ T cell immune responses generated by CRT/E7 DNA vaccination was found to be dependent on the time of administration of DMXAA and was also applicable to other antigen-specific vaccines. In addition, we determined that inducible nitric oxide synthase (iNOS) plays a role in the immune suppression caused by DMXAA administration before DNA vaccination. Our study has significant implications for future clinical translation.