bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pyogenic liver abscess and sepsis caused by mixed anaerobic bacteria in an immunocompetent adult: a case report
Authors: Fan Ziwen , Mei Mu , Chen Cen 
Published: February 2025

BackgroundAnaerobic bacterial communities in the digestive tract play an important role in digestive tract infections and aspiration pneumonia. However, ectopic infections originating from these communities are uncommon.Case reportWe present a rare case of a 64-year-old immunocompetent female was admitted with no significant medical history who developed a pyogenic liver abscess and sepsis caused by multiple anaerobic bacteria of digestive tract origin. Metagenomic next-generation sequencing (mNGS) detected four types of anaerobic bacteria in both peripheral blood and abscess puncture fluid. Culture confirmed the presence of three of these microorganisms. Treatment with a combination of meropenem and metronidazole resulted in the patient’s subsequent recovery and discharge.ConclusionThis report highlights the occurrence of ectopic infections caused by multiple anaerobic bacteria leading to pyogenic liver abscess and sepsis, underscoring the importance of considering anaerobic bacteria and conducting rapid comprehensive pathogen detection in clinical practice.
Long-term iron supplementation in four patients with X-linked erythropoietic protoporphyria: associations with serum proteins and erythrocyte protoporphyrin levels—a single-centre retrospective study
Authors: Minder Anna-Elisabeth , Granata Francesca , van Breemen Franziska , Schneider-Yin Xiaoye , Minder Elisabeth I. , Saleh Lanja , Barman-Aksözen Jasmin 
Published: February 2025

IntroductionX-linked erythropoietic protoporphyria (XLEPP) is an ultra-rare inborn error of the heme biosynthesis characterised by the accumulation of large amounts of protoporphyrin IX (PPIX) and zinc-protoporphyrin in the erythrocytes. PPIX absorbs the energy of the visible light range and upon exposure causes painful phototoxic reactions and tissue damage. In addition, PPIX is excreted via the liver and bile, and can induce liver failure that requires life-saving liver transplantation. Case reports and data from a limited number of patients enrolled in a prospective study indicate that supplementation with iron, a co-substrate of the heme biosynthesis, can decrease blood PPIX concentrations and improve liver damage and photosensitivity in patients with XLEPP. However, long-term data on safety and effectiveness of iron supplementation in XLEPP to support this treatment strategy is limited.MethodeHere, we report the experience and long-term effects over up to 8 years of iron supplementation of the four patients with XLEPP in the Swiss cohort.ResultsOur study shows that iron supplementation was safe and effective in lowering blood PPIX concentrations in our patients in the long term.DiscussionHowever, monitoring for adequate dosing and long-term effects is advisable and a standardisation of treatment protocols and international best practice guidelines are needed.
The relationship between lateral cervical lymph node positivity rate and recurrence after comprehensive treatment in differentiated thyroid carcinoma: a single-center retrospective cohort study from China
Authors: Ye Ting , Shao Shihan , Yao Shulin , Wang Ruimin 
Published: February 2025

IntroductionThe lateral cervical lymph node positivity rate has been hypothesized to correlate with the recurrence risk in differentiated thyroid carcinoma (DTC) patients. However, the extent of this association within the Chinese population remains understudied. This study seeks to elucidate the potential causal link between the lymph node positivity rate and DTC recurrence.MethodsWe conducted a retrospective cohort study, examining clinical records of 4,731 DTC patients who received surgical treatment at the First Medical Center of the General Hospital of the Chinese People’s Liberation Army from January 2015 to May 2020. The study variables encompassed demographic and clinical characteristics, including sex, age, tumor size, location, laterality, capsular invasion, lymph node metastasis counts, lymph node positivity rates, histological subtypes, Hashimoto’s thyroiditis co-occurrence, and the timing of iodine-131 therapy post-surgery. After applying strict inclusion criteria, 1,074 patients were selected for analysis. Recurrence was defined as structural incomplete response (SIR), confirmed by imaging or histological means. The lymph node positivity rate was calculated as the proportion of positive lymph nodes to the total lymph node count.ResultsMultivariate analysis revealed a nonlinear association between the lateral cervical lymph node positivity rate and post-treatment recurrence, with a significant threshold at 0.5. The recurrence risk was substantially elevated with a positivity rate below this threshold (HR: 27.48, 95% CI: 7.21–104.70, P&lt;0.0001), while no significant association was observed above it (HR: 0.17, 95% CI: 0.02–1.57, P=0.119). Subgroup analysis within the high-risk cohort did not yield a significant association between the positivity rate and recurrence risk (HR=0.43, 95% CI: 0.10–1.79, P=0.246).DiscussionIn conclusion, this study identifies a nonlinear relationship between the lateral cervical lymph node positivity rate and the risk of DTC recurrence post-treatment. A positivity rate of less than 0.5 is positively associated with recurrence, while this association diminishes in significance among high-risk patients. This differs from the results previously reported. Further studies are needed to determine the potential mechanisms of the associations observed in observational studies.
Evaluating the effectiveness of evidence-based falls prevention programs: a study on participant risk levels and program congruency
Authors: Elrod Cathy S. , Wong Rita A. 
Published: February 2025

BackgroundFalls are a leading cause of injury and injury-related deaths in older adults. A variety of community-delivered, evidence-based, fall risk-reduction programs have been developed and proven effective. These evidence-based fall prevention programs (EBFPP) have been classified along a fall-risk continuum, indicating the target fall-risk level of participants. The congruency between the program’s targeted and enrolled fall-risk level of participants is unknown. This study creates a fall-risk classification index, places participants into one of three fall risk categories, and then examines congruency of actual vs. recommended fall-risk of participants, by program.MethodsData came from the Healthy Aging Programs Integrated Database, created by the National Council on Aging (NCOA) funded by the Administration for Community Living (ACL) for use by ACL falls prevention program grantees. Using data from a pre-participation survey designed by the ACDL for their grantees, a fall risk index was created. The fall risk levels of the participants were then compared to the fall risk profile of the EBFPPs as identified in NCOA’s Evidence-based Falls Prevention Programs Risk Continuum Guidance for Program Selection in which they were enrolled.ResultsBetween July 2016 and June 2022, 105,323 older adults participated in one of eight EBFPPs. Participant characteristics varied among programs. Applying the fall risk index to the fall risk sample (31,064 older adults), 29% of participants were identified as being at high risk, 41% at moderate risk, and 30% at low risk. When the fall risk level of participants, by program, was compared to the target risk profile of the associated EBFPP, programs that had a risk profile targeting individuals at moderate to low risk were found to enroll a larger percentage of adults at high risk than expected. All programs enrolled at least some participants at each of the three risk levels.ConclusionAll eight EBFPPs enrolled participants across all three fall-risk levels with most programs being at least somewhat congruent with the fall-risk program continuum recommendations. More research is needed to better understand inconsistencies between risk-levels of program, target risk-levels, and actual participant risk-level, to guide either adaptations in the risk-level classification or program modifications to accommodate different risk-levels.
Saline–Alkali Tolerance Evaluation of Giant Reed (Arundo donax) Genotypes Under Saline–Alkali Stress at Seedling Stage
Authors: Cai Yangxing , Cao Xiuming , Liu Bin , Lin Hui , Luo Hailing , Liu Fengshan , Su Dewei , Lv Shi , Lin Zhanxi , Lin Dongmei 
Published: February 2025

Soil salinization and alkalization are serious global challenges that adversely affect crop growth and yield. In this study, six genotypes of giant reed (Arundo donax) seedlings (LvZhou_No.1, LvZhou_No.3, LvZhou_No.6, LvZhou_No.11, LvZhou_No.12 and LvZhou_Var.) originating from different regions of China and Rwanda were utilized as experimental materials. This study aimed to investigate the physiological and biochemical responses of various genotypes to saline–alkali stress and to identify stress-tolerant resources. A mixture saline–alkali solution with a molar ratio of NaCl: Na2SO4: NaHCO3: Na2CO3 = 1:1:1:1 was prepared at three concentrations (75, 150 and 225 millimolar (mM)) for a 7-day pot experiment. Growth and physiological indices were measured at the seedling stage, and salt tolerance was evaluated accordingly. The results indicated the following: the growth indices were significantly reduced across seedlings of all genotypes when the concentration of stress exceeded 150 mM (p < 0.05). There was no significant difference in chlorophyll content (SPAD value) and maximum photochemical efficiency of PS II (Fv/Fm) with increasing saline–alkali stress. However, the photosynthetic rate (Pn), stomatal conductance (Gs) and transpiration rate (Tr) exhibited decreasing trends, reaching their lowest levels at 225 mM. In contrast, the intercellular CO2 concentration (Ci) value decreased to its lowest at 150 mM but increased at 225 mM. Relative electrical conductivity (REC) and the contents of malondialdehyde (MDA), proline (Pro) and soluble sugar (SS) increased progressively with higher stress concentrations. The activities of superoxide dismutase (SOD), peroxidase (POD) and catalase (CAT) were significantly enhanced at stress concentrations above 150 mM. The saline–alkali tolerance of A. donax seedlings was comprehensively evaluated using principal component analysis and membership function analysis based on 15 parameters. The results indicate that Pn, Tr and Gs are effective physiological indicators for assessing saline–alkali tolerance of A. donax seedlings. The six genotypes were ranked for saline–alkali tolerance as follows: LZ_No.1 > LZ_No.11 > LZ_No.12 > LZ_Var. > LZ_No.3 > LZ_No.6. This indicates that LZ_No.1 shows the highest resistance to saline–alkali stress, whereas LZ_No.6 is the most severely affected, classifying it as a salinity-sensitive genotype. In conclusion, LZ_No.1 exhibits robust saline–alkali tolerance and represents a valuable germplasm resource for improving saline–alkali tolerance in A. donax propagation. The results not only support the development of resilient plants for saline–alkali environments but also offer insights into the mechanisms of salinity tolerance.
Non-Robotic Endoscopic-Assisted Internal Mammary Artery Harvest—A Historical Review and Recent Advancements
Authors: Görtzen De Qing , Sampon Fleur , Ter Woorst Joost , Akca Ferdi 
Published: February 2025

Background: The non-robotic endoscopic harvest of the internal mammary artery (IMA) facilitates minimally invasive bypass grafting while minimizing chest wall trauma. The technique was pioneered in the early 1990s and has recently regained popularity due to its accessibility and reproducibility. This review aims to provide an overview of endoscopic IMA harvest from its inception to the present. Methods: In August 2024, a literature search was performed using the electronic databases of the Cochrane Controlled Trials Register (CCTR) and PubMed. To obtain optimal search results, the keywords “thoracoscopic”, “endoscopic”, “minimally invasive”, “video-assisted”, “video-assisted thoracoscopic surgery VATS”, and “internal mammary artery” or “internal thoracic artery” were used, excluding the term “robotic”. References from the extracted articles were also reviewed to identify additional studies on endoscopic IMA harvest. Results: A total of 17 articles were included in the final analysis. Left internal mammary artery (LIMA) harvest times of between 17 and 164 min were reported, with an injury to LIMA rates between 0.7 and 2.2%. Conclusions: After a 15-year period without scientific publications, interest in the endoscopic-assisted approach has rekindled in recent years due to the reduction in chest trauma compared to direct vision harvest and the widespread availability of conventional endoscopic tools. This renewed focus underscores the potential to make minimally invasive coronary surgery available in all centers.
Direito, política e economia no processo de efetivação de direitos humanos: análise da crise venezuelana e a situação de refúgio
Authors: Barbosa Noêmia Carla Cruz , Sobrinho Luis Carlos dos Santos Lima 
Published: February 2025

O presente artigo analisa as interações dispostas entre o espaço político, econômico, jurídico e social no processo de concretização e viabilidade dos direitos humanos, propagado na esfera nacional e internacional por intermédio de institutos, decretos, tratados, sistemas e cortes. Neste contexto, objetiva-se incialmente apresentar breves reflexões acerca da proclamação da Declaração dos Direitos Humanos e a figura estatal como garantidora destes direitos, vinculando-se nesta análise a exposição de sistemas e instituições atuantes na defesa das aludidas garantias. Para isto, utiliza-se como procedimento metodológico o estudo dogmático, em análise qualitativa e método exploratório e descritivo, de forma que são apresentadas e contextualizadas obras e fontes documentais pertinentes a problemática da eventual pesquisa, objeto de análise de conteúdo. Adota-se como exemplificação a problemática centrada o efeito migratório advindo da crise venezuelana, analisando-se por fim, os desafios vivenciados por indivíduos que se encontram em situação de refúgio no Brasil. Ressalta-se a imprescindibilidade de condições necessárias para a efetivação dos respectivos direitos e as consequências advindas da não concepção de um cenário propício para o exercício das liberdades e garantias reconhecidas.
Prevalensi dan Hubungan Infeksi Protozoa Usus dengan Kejadian Diare di RSUD Kemayoran Tahun 2020-2021
Authors: Sari Monica Puspa , Pandapotan Roy Akur , Agustina Nurul Fitria 
Published: February 2025

Infeksi protozoa usus masih menjadi permasalahan di dunia, terutama di negara berkembang seperti Indonesia dengan angka prevalensi 10-18%. Infeksi protozoa usus dapat menyebabkan diare pada anak. Tujuan penelitian adalah ingin mengetahui prevalensi dan hubungan protozoa usus pada penderita diare yang dirawat di RSUD Kemayoran Jakarta. Metode penelitian yaitu analitik deskriptif dengan pendekatan cross sectional menggunakan data rekam medik penderita diare pada tahun 2020-2021 di RSUD Kemayoran. Hasil penelitian ini menunjukkan dari 76 responden didapatkan bahwa kejadian diare di RSUD Kemayoran pada tahun 2020 sampai 2021 paling banyak terjadi pada anak laki laki dengan prevalensi protozoa usus (10,5%). Entamoeba histolytica merupakan protozoa usus yang paling sering menyebabkan diare pada anak. Gejala mual ditemukan sebanyak 5,3%, tanpa dehidrasi sebanyak 6,6% dengan lama rawat 3 hari (9,2%). Hasil uji Fisher menunjukkan bahwa terdapat hubungan yang bermakna antara infeksi protozoa usus dengan gejala mual yang timbulkan (p=0,044), terdapat hubungan antara infeksi protozoa usus dengan karakteristik tinja yang cair (p=0,048) dan berlendir (p=0,045). Hasil uji Mann Whitney menunjukkan bahwa terdapat hubungan antara infeksi protozoa usus dengan usia, pekerjaan dan tingkat pendidikan (p=0,000) serta kadar hemoglobin (p=0,013). Kesimpulan terdapat hubungan antara infeksi protozoa usus dengan gejala mual, konsistensi tinja, usia, pekerjaan, tingkat pendidikan dan kadar hemoglobin.
Pour une acceptation chrétienne du trouble
Authors: Le Goaziou Thierry 
Published: February 2025

La crise sanitaire a brusquement plongé la planète dans l’ère de l’incertitude et du manque de lisibilité. Cette crise a le mérite de souligner une réalité méconnue ; celle de l’intervention sur autrui que les équipes de soignants exercent auprès des personnes souffrantes et handicapées. La gestion de la Covid met en évidence la vulnérabilité de l’être humain. L’irruption de ce virus est dérangeante car elle rappelle la proximité de la mort. La pandémie nous invite à apprendre à vivre avec nos craintes et nos peurs. La notion de trouble, issue de la rencontre avec le monde du handicap, constitue une topique majeure qui rappelle l’universalité de la sensibilité humaine. Au sein d’un espace communicationnel saturé et confus, le chrétien doit ainsi pouvoir rendre compte de sa capacité à vivre ses propres troubles au sein d’une acceptation lucide de ses limites. C’est comme un être troublé qu’il se tient devant la face de Dieu à travers trois repères : la liminalité, la confiance et la démaîtrise. Discipline : théologie morale
Quand le temps collectif est « usé ». Une réflexion d’anthropologie culturelle
Authors: Arènes Jacques 
Published: February 2025

L’incertitude est au cœur d’un travail contemporain de culture en un registre où la temporalité individuelle – c’est-à-dire la manière dont le psychisme humain compose avec le temps – se trouve mise en difficulté en raison de « l’usure » du temps collectif. Cet article analyse ainsi, dans une perspective d’anthropologie culturelle informée par la psychanalyse et par l’approche phénoménologique de la temporalité (notamment celle de Ludwig Binswanger et d’Eugène Minkowski), la manière dont la traversée de « l’épaisseur des temps », selon la formule de Péguy, serait encore possible, même si le futur se révèle difficile à « porter ». Il s’agit alors de penser une dimension « pathique » de l’existence, compatible avec un certain déterminisme psychanalytique, et d’en reconnaître néanmoins l’inventivité créative jusqu’au cœur des accidents et des bifurcations de la vie. Des exemples issus d’accompagnements psychothérapiques viennent en appui de l’apport théorique. Disciplines : psychanalyse, psychologie clinique .
Factores que inciden en la oferta de palma aceitera en Ecuador
Authors: Zambrano Carlos , Morales Fátima , Patiño Javier , Muñoz Kianna 
Published: February 2025

Además del precio del producto, entre los factores para determinar la cantidad de un artículo a ofertar en un momento determinado son los precios de los recursos, precios de otros bienes, tecnología y las expectativas del productor. La palma africana es cosechada para producir el aceite vegetal más usado en el mundo como materia prima para subproductos entre los que se destaca la grasa para alimentos de panificación, aceites de consumo humano, jabones, cosméticos y biocombustibles. El objetivo de este estudio fue evaluar los factores que inciden en la oferta de palma aceitera en el Ecuador. Los datos fueron obtenidos del Sistema de Información Pública Agropecuaria, Banco Central del Ecuador, y el Instituto Nacional de Estadísticas y Censos, para el período 2010-2023. La herramienta utilizada para registrar la información fue Microsoft Excel y para el modelamiento de factores el software SPSS. Estadísticamente existe una relación significativa entre la superficie cosechada y la cantidad exportada así también una asociación positiva muy fuerte entre los precios nacionales e internacionales. El modelo de regresión es adecuado en que la Superficie cosechada es altamente significativa, mientras que crédito público y cantidad de palma exportada presentan un bajo nivel de significación.
Possible provenance of IRD by tracing late Eocene Antarctic iceberg melting using a high-resolution ocean model
Authors: Elbertsen Mark V. , van Sebille Erik , Bijl Peter K. 
Published: February 2025

Abstract. The Eocene–Oligocene transition (EOT) is characterised by the inception of the large-scale Antarctic ice sheet. However, evidence of earlier glaciation during the Eocene has been found, including the presence of ice-rafted debris (IRD) at Ocean Drilling Program (ODP) Leg 113 Site 696 on the South Orkney Microcontinent (SOM) (Carter et al., 2017). This suggests marine-terminating glaciers should have been present in the southern Weddell Sea region during the late Eocene, generating sufficiently large icebergs to the South Orkney Microcontinent to survive the high Eocene ocean temperatures. Here, we use Lagrangian iceberg tracing in a high-resolution eddy-resolving ocean model of the late Eocene (Nooteboom et al., 2022) to show that icebergs released from offshore the present-day Filchner Ice Shelf region and Dronning Maud Land could reach the South Orkney Microcontinent during the late Eocene. The high melt rates under the Eocene warm climate require a minimum initial iceberg mass on the order of 100 Mt and an iceberg thickness of several tens of metres to be able to reach the South Orkney Microcontinent. Although this places the iceberg mass at the larger end of the present-day range of common iceberg masses around Antarctica, the minimum estimates are not unfeasible; hence, the present study confirms previous findings suggesting glaciation and iceberg calving were possible in the late Eocene.
Effectiveness of Behavioral and Lifestyle Changes in Reducing TMD Symptoms: Evidence from a Structured Intervention
Authors: Dunya Malhan Hanweet  , Karar Abdulzahra Mahdi  , Ansam Mahdi Khalel  , Ibrahim Salah M. 
Published: February 2025

Objective: To assess the effectiveness of behavioral measures in managing TMDs with an emphasis on pain, joint mobility and psychosocial status.
Methods: Forty-eight subjects with TMDs were enrolled based on the RDC/TMD criteria. Stress management, ergonomics training, dietary changes and stretching exercises were recommended as individualized lifestyle plans. The clinical, psychosocial and functional evaluations were done before and after three months of intervention.
Results: The frequency of myofascial pain without limited mouth opening was 45. 8% which was reduced to 20. The percentage of subjects with right and left TMJ arthralgia was also seen to have reduced significantly (70. 8% to 43. 7%, p = 0. 0133; 75% to 41. 6%, p = 0. 001). Right TMJ osteoarthrosis and osteoarthritis showed a considerable improvement (p < 0. 05) while the changes in the left TMJ were not significant. Disc displacement with reduction on the right and without reduction on the left side was also found to have improved markedly (p = 0. 036; p = 0. 041). Depression severity was also found to have reduced significantly with the normal levels increasing from 45. 8% to 83. 3% (p < 0. 05). Pain intensity as measured by VAS also reduced from 4. 72 ± 1. 44 to 3. 43 ± 1. 38 (p = 0. 001). There was also an enhancement in the non-specific physical symptoms but the differences were not statistically significant.
Conclusions: The present study demonstrated that the implementation of lifestyle modifications helps in decreasing the symptoms of TMD, increases the joint function and has a positive effect on the psychosocial status of the patients and therefore should be considered as the first-line treatment in the management of TMD.