bluuebunny/crossref_metadata_2025_split huggingface dataset:
Rinse fluid and imprint smear cytology of bronchial biopsies in diagnosis of lung tumors
Authors: Goyal Shilpa , Mohan Harsh , Uma Handa  , Saini Varinder 
Published: November 2010

AbstractThe usefulness of rinse fluid and imprint smear cytology of the bronchial biopsy has been studied in diagnosis of lung cancer. However, scarce data is available regarding rinse fluid cytology of biopsy. The aim of this study was to evaluate these cytologic techniques for their diagnostic accuracy. Bronchial biopsy was taken in 52 patients clinically/radiologically suspected to have lung carcinoma. Imprint smears of the biopsy were prepared, following which it was put in balanced saline solution to collect rinse fluid of biopsy before transferring it to formalin for fixation. Cytological diagnosis from imprint and rinse fluid smears was compared with histopathological diagnosis. Malignancy was detected in 45 cases of 52 patients on histopathology. Positive result was given by rinse fluid cytology in 34 (65.4%) cases while diagnostic accuracy was 78.8%. The imprint smears were positive for malignancy in 44 (84.6%) cases with diagnostic accuracy of 98.08%. There were no false–positive results, but one case was incorrectly typed by both the techniques. Imprint smear cytology has a better diagnostic accuracy and efficacy over rinse fluid while the two cytologic techniques can be used in combination routinely with biopsy to provide an early and reliable diagnosis in lung cancer. Diagn. Cytopathol. 2011. © 2010 Wiley Periodicals, Inc.
Calcinosis cutis: Diagnosis by fine needle aspiration cytology—A rare case report
Authors: Agrawal Pallavi , Banik Tarak , Dey Pranab 
Published: November 2010

AbstractCalcinosis cutis is characterized by deposition of calcium salts in the subcutaneous tissues in the body. In this study, we described a case of calcinosis cutis that was diagnosed by fine needle aspiration (FNA) in a 15‐year‐old male. The patient presented with multiple nodules over right forearm and right knee. FNA smears showed flakes of amorphous material indicating calcium along with few macrophages. The presence of amorphous calcium salts along with histiocytes in the appropriate clinical settings is diagnostic of calcinosis cutis. Diagn. Cytopathol. 2011. © 2010 Wiley Periodicals, Inc.
Microarray identification of novel downstream targets of FoxD4L1/D5, a critical component of the neural ectodermal transcriptional network
Authors: Yan Bo , Neilson Karen M. , Moody Sally A. 
Published: November 2010

AbstractFoxD4L1/D5 is a forkhead transcription factor that functions as both a transcriptional activator and repressor. FoxD4L1/D5 acts upstream of several other neural transcription factors to maintain neural fate, regulate neural plate patterning, and delay the expression of neural differentiation factors. To identify a more complete list of downstream genes that participate in these earliest steps of neural ectodermal development, we carried out a microarray analysis comparing gene expression in control animal cap ectodermal explants (ACs), which will form epidermis, to that in FoxD4L1/D5‐expressing ACs. Forty‐four genes were tested for validation by RT‐PCR of ACs and/or in situ hybridization assays in embryos; 86% of those genes up‐regulated and 100% of those genes down‐regulated in the microarray were altered accordingly in one of these independent assays. Eleven of these 44 genes are of unknown function, and we provide herein their developmental expression patterns to begin to reveal their roles in ectodermal development. Developmental Dynamics 239:3467–3480, 2010. © 2010 Wiley‐Liss, Inc.
The long‐term efficacy of three psychotherapies for anorexia nervosa: A randomized, controlled trial
Authors: Carter Frances A. , Jordan Jennifer , McIntosh Virginia V.W. , Luty Suzanne E. , McKenzie Janice M. , Frampton Christopher M.A. , Bulik Cynthia M. , Joyce Peter R. 
Published: November 2010

AbstractObjective:To evaluate the long‐term efficacy of three psychotherapies for anorexia nervosa.Method:Participants were women with broadly defined anorexia nervosa who had participated in a RCT comparing specialized psychotherapies (cognitive behavior therapy, CBT, and interpersonal psychotherapy, IPT) with a control condition (specialist supportive clinical management, SSCM), and attended long‐term follow‐up assessment (mean 6.7 years ± 1.2).Results:Forty three of the original sample of 56 women participated in long‐term follow‐up assessment (77%). No significant differences were found on any pre‐selected primary, secondary or tertiary outcome measures among the three psychotherapies at long‐term follow‐up assessment. Significantly different patterns of recovery were identified for the psychotherapies across time on the primary global outcome measure. Although SSCM was associated with a more rapid response than IPT, by follow‐up all three treatments were indistinguishable.Discussion:Potential implications for the timing of interventions to improve treatment response in anorexia nervosa are critically examined. © 2010 by Wiley Periodicals, Inc. Int J Eat Disord 2010
Computationally efficient bootstrap prediction intervals for returns and volatilities in ARCH and GARCH processes
Authors: Chen Bei , Gel Yulia R. , Balakrishna N. , Abraham Bovas 
Published: November 2010

AbstractWe propose a novel, simple, efficient and distribution‐free re‐sampling technique for developing prediction intervals for returns and volatilities following ARCH/GARCH models. In particular, our key idea is to employ a Box–Jenkins linear representation of an ARCH/GARCH equation and then to adapt a sieve bootstrap procedure to the nonlinear GARCH framework. Our simulation studies indicate that the new re‐sampling method provides sharp and well calibrated prediction intervals for both returns and volatilities while reducing computational costs by up to 100 times, compared to other available re‐sampling techniques for ARCH/GARCH models. The proposed procedure is illustrated by an application to Yen/U.S. dollar daily exchange rate data. Copyright © 2010 John Wiley & Sons, Ltd.
Characteristics of the 2000 fissure eruption and lava flow fields at Mount Cameroon volcano, West Africa: a combined field mapping and remote sensing approach
Authors: Wantim M.N. , Suh C.E. , Ernst G.G.J. , Kervyn M. , Jacobs P. 
Published: November 2010

AbstractThis study focuses on the compound pahoehoe lava flow fields of the 2000 eruption on Mount Cameroon volcano, West Africa and it comprehensively documents their morphology. The 2000 eruption of Mount Cameroon took place at three different sites (sites 1, 2 and 3), on the southwest flank and near the summit that built three different lava flow fields. These lava flow fields were formed during a long‐duration (28th May–mid September) summit and flank eruption involving predominantly pahoehoe flows (sites 2 and 3) and aa flows (site 1). Field observations of flows from a total of four cross‐sections made at the proximal end, midway and at the flow front, have been supplemented with data from satellite imagery (SRTM DEM, Landsat TM and ETM+) and are used to offer some clues into their emplacement. Detailed mapping of these lava flows revealed that site 1 flows were typically channel‐fed simple aa flows that evolved as a single flow unit, while sites 2 and 3 lava flow fields were fed by master tubes within fissures producing principally tube‐fed compound pahoehoe flows. Sites 2 and 3 flows issued from ∼ 33 ephemeral vents along four NE–SW‐trending faults/fissures. Pahoehoe morphologies at sites 2 and 3 include smooth, folded and channelled lobes emplaced via a continuum of different mechanisms with the principal mechanism being inflation. The dominant structural features observed on these flow fields included: fissures/faults, vents, levees, channels, tubes and pressure ridges. Other structural features present were pahoehoe toes/lobes, breakouts and squeeze‐ups. Slabby pahoehoe resulting from slab‐crusted lava was the transitionary lava type from pahoehoe to aa observed at all the sites. Transition zones correspond to slopes of > 10°. Variations in flow morphology and textures across profiles and downstream were repetitive, suggesting a cyclical nature for the responsible processes. Copyright © 2010 John Wiley & Sons, Ltd.
Indications for radiotherapy after neck dissection
Authors: Strojan Primož , Ferlito Alfio , Langendijk Johannes A. , Silver Carl E. 
Published: November 2010

AbstractUp‐front surgery and postoperative radiotherapy constitute a well‐recognized treatment concept for locally or regionally advanced squamous cell carcinoma of the head and neck. This “treatment package” is further intensified with the concomitant application of chemotherapy during irradiation when high‐risk features (ie, microscopically involved resection margins, extracapsular extension of the tumor from neck nodes, the presence of soft tissue deposits) are found on histopathologic examination of a resected specimen. With regard to neck disease, however, the demarcation line between low‐ and higher‐risk clinical situations, which would differ with respect to the need for postoperative radiotherapy, is not clear. In an attempt to define the low‐risk characteristics of disease in the neck that do not require adjuvant irradiation, we reviewed the available literature reports for any direct or indirect evidence on the value of postoperative radiotherapy in various clinical scenarios. The number of positive lymph nodes found in a dissected tissue specimen that should be used as a “cut‐off” point for introduction of postoperative radiotherapy was evaluated in the context of both primary tumor characteristics and type of neck dissection. © 2010 Wiley Periodicals, Inc. Head Neck, 2012
Complete resolution of laryngeal amyloidosis with radiation treatment
Authors: Neuner Geoffrey A. , Badros Ashraf A. , Meyer Tanya K. , Nanaji Nahid M. , Regine William F. 
Published: November 2010

AbstractBackground.Localized amyloidosis of the larynx is a rare entity of unclear etiology. Surgical debulking is the primary treatment modality but often is not curative.Methods and Results.A 41‐year‐old woman presenting with increasing hoarseness, dysphagia, dyspnea, and weight loss was found to have a submucosal mass in the left false vocal fold. Biopsy of the specimen revealed amyloid. After negative work‐up for systemic disease, the patient underwent surgical debulking. Specimens revealed a population of clonal plasma cells demonstrating lambda restriction. The patient was treated with adjuvant external beam radiation to a dose of 45 Gy. At 11 months, the patient's voice, breathing, and swallowing have all improved substantially.Conclusions.Recent pathologic studies suggest that localized amyloidosis of the larynx is caused by a localized, nonmalignant plasma cell disorder. Because full resection is difficult, we recommend a combination of surgery and radiation therapy to cure this disease. © 2010 Wiley Periodicals, Inc. Head Neck, 2012
Soil water movement under a bottomland hedgerow during contrasting meteorological conditions
Authors: Ghazavi R. , Thomas Z. , Hamon Y. , Merot Ph. 
Published: November 2010

AbstractLinear vegetation structures such as hedge tree networks (hedgerows), shelterbelts, and isolated trees play a major role on soil water transfer. Our objective is to evaluate the influence of a bottomland hedgerow on water flux in the saturated and unsaturated zones. Soil water movement was investigated in a hillslope crossed by a hedgerow using total water‐potential gradients and shallow groundwater dynamics. Results of a dry year were presented by Ghazavi et al. (2008). In this study, we analyse a wet year and then compare the two contrasting years (dry and wet). During the 2 years, the soil located at the vicinity of the hedgerow developed a drier status than the surrounding soils. Water flux in the unsaturated zone was directed towards the hedgerow for a longer period during the dry year than the wet year. The duration of delayed rewetting of the soil decreased from 3 months for the dry year to 1 month for the wet year. Variation in water storage calculated over the study period was highest near the hedgerow and lowest far from the hedgerow.In the hillslope studied, hedgerow and stream proximity controlled water transfer. It is clear that the hedgerow controlled water transfer in the unsaturated zone throughout the year, except for the period when the soil profile was fully saturated. First, hedgerows control water transfer by increasing lateral transfer, which is related to high soil water potential gradients in its vicinity. These processes may increase capillary rise and decrease groundwater recharge near the hedgerow. Second, reverse hydraulic gradient (upward flux of water) occurred during the period of lowest groundwater level, mainly because of groundwater and stream connectivity. Processes related to hedgerow presence, such as delayed soil rewetting and flow towards the hedgerow need to be considered to quantify the impact of linear vegetation structures on water flux. Copyright © 2010 John Wiley & Sons, Ltd.
Schnurri‐2 deficiency counteracts against bone loss induced by ovariectomy
Authors: Nagao Masashi , Saita Yoshitomo , Hanyu Ryo , Hemmi Hiroaki , Notomi Takuya , Hayata Tadayoshi , Nakamoto Tetsuya , Nakashima Kazuhisa , Kaneko Kazuo , Kurosawa Hisashi , Ishii Shunsuke , Ezura Yoichi , Noda Masaki 
Published: November 2010

AbstractSchnurri (Shn)‐2 is a transcriptional modulator of bone formation and bone resorption and its deficiency causes low turnover state with higher cancellous bone mass due to the defects in osteoclasts that exceeds the defects in osteoblasts in mice. We addressed whether such low turnover of bone remodeling in Shn2 deficiency may be modulated in the absence of estrogen that induces high turnover state in vivo. Ovariectomy reduced bone mass in wild type compared to sham operated control mice and such reduction in bone mass was also observed in Shn2 deficient mice. However, due to the high levels of basal bone mass in Shn2 deficient mice, the bone mass levels after ovariectomy were still comparable to sham operated wild‐type mice. Analysis indicated that estrogen depletion increased bone resorption at similar levels in wild type and Shn2 deficient mice though the basal levels of osteoclast number was slightly lower in Shn2‐deficient mice. In contrast, basal levels of bone marrow cell mineralization in cultures were low in Shn2‐deficeint mice while estrogen depletion increased the mineralization levels to those that were comparable to sham wild type. This indicates that Shn2‐deficient mice maintain bone mass at the levels comparable to wild‐type sham mice even after ovariectomy‐induced bone loss and this correlates with the high levels of mineralization activity in bone marrow cells after ovariectomy. J. Cell. Physiol. 226: 573–578, 2011. © 2010 Wiley‐Liss, Inc.
Osteoinduction by repeat plasmid injection of human bone morphogenetic protein‐2
Authors: Osawa Kenji , Okubo Yasunori , Nakao Kazumasa , Koyama Noriaki , Bessho Kazuhisa 
Published: November 2010

AbstractBackgroundBone morphogenetic protein‐2 (BMP‐2) is an osteoinductive protein and is considered useful for the treatment of skeletal disorders. Previous studies using BMP‐2 in clinical applications have encountered difficulties, including the lack of an efficient, safe, inexpensive and simple delivery system. The gene transfer approach is a promising option for utilizing BMP‐2. Although viral vector‐mediated gene transfer is efficient, safety concerns prevent its clinical application for common diseases. On the other hand, plasmid‐based gene transfer is a safe method and can be harnessed for practical applications.MethodsA plasmid encoding human BMP‐2 (pCAGGS‐BMP‐2) was used and injected repeatedly (one to eight times) into the skeletal muscle of mice at a divided dose. We compared the capability of osteoinduction in the skeletal muscle of mice after gene transfer by repeat injection. BMP‐2 production was assessed via immunohistochemistry, and osteoinduction was evaluated using radiography, histology and biochemical assays.ResultsThe BMP‐2 gene was transferred into the skeletal muscle of mice by repeat injection using pCAGGS‐BMP‐2. Mature bone was frequently observed in mice injected repeatedly with pCAGGS‐BMP‐2 at a divided dose. This confirms that, if the total dose is fixed, repeat injection with pCAGGS‐BMP‐2 at a divided dose causes osteoinduction more frequently in the skeletal muscle of mice.ConclusionsThese results suggest the possibility of the effective clinical use of human BMP‐2 gene therapy by direct DNA injection, and facilitate the clinical application of BMP‐2 gene therapy. Copyright © 2010 John Wiley & Sons, Ltd.
Facial bristle feather histology and morphology in New Zealand birds: Implications for function
Authors: Cunningham Susan J. , Alley Maurice R. , Castro Isabel 
Published: November 2010

AbstractKnowledge of structure in biology may help inform hypotheses about function. Little is known about the histological structure or the function of avian facial bristle feathers. Here we provide information on morphology and histology, with inferences for function, of bristles in five predominantly insectivorous birds from New Zealand. We chose species with differing ecologies, including: brown kiwi (Apteryx mantelli), morepork (Ninox novaezealandae), hihi (Notiomystis cincta), New Zealand robin (Petroica australis), and New Zealand fantail (Rhipidura fuliginosa). Average bristle length corrected for body size was similar across species. Bristles occurred in distinct groups on different parts of the head and upper rictal bristles were generally longest. The lower rictal bristles of the fantail were the longest possessed by that species and were long compared to bristles of other species. Kiwi were the only species with forehead bristles, similar in length to the upper rictal bristles of other species, and the lower rictal bristles of fantails. Herbst corpuscles (vibration and pressure sensitive mechanoreceptors) were found in association with bristle follicles in all species. Nocturnal and hole‐nesting birds had more heavily encapsulated corpuscles than diurnal open‐nesting species. Our results suggest that avian facial bristles generally have a tactile function in both nocturnal and diurnal species, perhaps playing a role in prey handling, gathering information during flight, navigating in nest cavities and on the ground at night and possibly in prey‐detection. These differing roles may help explain the observed differences in capsule thickness of the corpuscles. J. Morphol., 2011. © 2010 Wiley‐Liss, Inc.
Instability of syllable repetition in Parkinson's disease—Influence of levodopa and deep brain stimulation
Authors: Skodda Sabine , Flasskamp Andrea , Schlegel Uwe 
Published: November 2010

AbstractThe aim of this study was to test the hypothesis of a fundamental impairment of vocal pace performance in Parkinson's disease (PD) based on a syllable repetition paradigm and the influence of levodopa and deep brain stimulation of the subthalamic nucleus (STN‐DBS). Twenty‐two PD patients under stable dopaminergic medication, 14 patients with STN‐DBS, and 30 controls were tested. Participants had to repeat the syllable /pa/ in a steady pace. Percental coefficient of variance (COV) of interval length was measured for the description of pace stability. Patients were tested in the OFF state and again in the ON state after levodopa administration or ongoing STN‐DBS. COV was elevated in both PD subgroups. COV was not influenced by levodopa administration but showed a further deterioration under STN‐DBS. The impaired syllable repetition capacity shows similarities to the patterns of more complex speech rhythm abnormalities in PD and therefore might share the same pathophysiology. © 2010 Movement Disorder Society
The outcome and prognostic factors of twin–twin transfusion syndrome following fetoscopic laser surgery
Authors: Sago Haruhiko , Hayashi Satoshi , Saito Mari , Hasegawa Hiromi , Kawamoto Hiroshi , Kato Naomi , Nanba Yukiko , Ito Yushi , Takahashi Yuichiro , Murotsuki Jun , Nakata Masahiko , Ishii Keisuke , Murakoshi Takeshi 
Published: November 2010

AbstractObjectivesTo evaluate the outcome and preoperative risks of twin–twin transfusion syndrome (TTTS) following fetoscopic laser surgery (FLS).MethodsA retrospective cohort study of a series of 181 consecutive cases of TTTS before 26 weeks' gestation subjected to FLS at four centers in Japan between July 2002 and December 2006.ResultsThe chances of survival of at least one twin at 28 days of age and 6 months of age were 91.2% and 90.1%, respectively. The rate of major neurological complications in survivors at 6 months of age was 4.7%. Preoperative findings that were significant risk factors for death were as follows: (1) being donor [odds ratio (OR): 3.01, 95% confidence interval (CI): 1.24–7.31, P = 0.015]; (2) reversed (OR: 11.78, CI: 3.05–45.55, P < 0.001) and absent (OR: 3.95, CI: 1.66–9.43, P = 0.002) end‐diastolic velocity in the umbilical artery (EDV‐UA) of the donor; and (3) reversed blood flow in the ductus venosus of the recipient (OR: 2.35, CI: 1.04–5.29, P = 0.040).ConclusionsFLS leads to high survival rates and low neurological morbidity for fetuses in TTTS. FLS is an effective therapeutic option for TTTS before 26 weeks of gestation. Preoperative Doppler findings of the umbilical artery and the ductus venosus are useful in predicting prognosis following FLS. Copyright © 2010 John Wiley & Sons, Ltd.
Chemically bonded iron carbonyl for magnetic composites based on phthalonitrile polymers
Authors: Jia Kun , Xu Mingzhen , Zhao Rui , Liu Xiaobo 
Published: November 2010

AbstractDicarboxylic acid‐containing 1,3‐benzoxazine was synthesized and chemically bonded on iron carbonyl particles using a post‐coating method. Novel organic–inorganic hybrid magnetic composites were prepared via the interfacial reaction between magnetic phthalonitrile prepolymers and the benzoxazine functional coatings that chemically modified the iron carbonyl particles. The results showed that, compared with pure iron carbonyl particles, the modified particles could cure the phthalonitrile prepolymers efficiently and improve the interfacial compatibility of the functional composites. The magnetic composites with chemically modified particles exhibited stronger magnetism in comparison to composites containing bare particles: the saturation magnetization of the magnetic composites with equal concentration (5 wt%) of Fe(CO)5 increased from 41.12 to 48.82 emu g−1. Also, the magnetic composites obtained demonstrated excellent thermal stability up to 500 °C. Copyright © 2010 Society of Chemical Industry
Curing reactions and properties of organic–inorganic composites from hydrogenated carboxylated nitrile rubber and epoxycyclohexyl polyhedral oligomeric silsesquioxanes
Authors: Liu Qing , Ren Wentan , Zhang Yong , Zhang Yinxi 
Published: November 2010

AbstractNovel organic–inorganic composites were prepared by curing hydrogenated carboxylated nitrile rubber (HXNBR) with epoxycyclohexyl polyhedral oligomeric silsesquioxanes (POSS) through chemical bonding of carboxyl groups of HXNBR and epoxy groups of POSS. The process of the curing reaction was investigated using in situ Fourier transform infrared spectroscopy. The reaction order, the activation energy and the frequency factor were obtained through a kinetic analysis using differential scanning calorimetry. Through dynamic mechanical analysis, the glass transition temperature, crosslink density and degree of heterogeneity of the composites were estimated, and they showed an increasing tendency with increasing POSS content. The results of dielectric property measurements showed that the dielectric constant of the composites decreased with increasing POSS content in the studied frequency range. Copyright © 2010 Society of Chemical Industry