bluuebunny/crossref_metadata_2025_split huggingface dataset:
L'aventure de la bâtardise critique : rupture, filiation et mise en abyme dans Les Faux-monnayeurs
Authors: Lacroix Michel 
Published: July 2011

Résumé Notre article examine le glissement progressif, opéré dans Les Fauxmonnayeurs , de l’héroïsation de la bâtardise et de l’aventure, vers une autre conception, plus critique, qui intègre rupture et filiation. Or, par le biais d’un jeu d’équivalence, ce double mouvement de valorisation et de critique de la rupture est reportée sur la figure du romancier, puis sur le roman lui-même, qui se fait roman impur, roman critique, bien plus que « pur roman », comme le conçoit une partie de la critique gidienne. Cette pensée et pratique du roman font de ce genre l’école de la rupture, de la recherche des règles, en même temps qu’un lieu où développer une pensée sur l’homme, sur la genèse des valeurs.
Cyclooxygenase inhibitor improved an exudative lesion of choroidal neovascularization in age-related macular degeneration
Authors: Suzuki Misa , Suzuki Takayoshi , Nagano Aoi , Hirasawa Manabu , Sakuyama Kenichi , Mizuki Nobuhisa 
Published: July 2011

Purpose To report a case in which a nonselective cyclooxygenase (COX) inhibitor improved an exudative lesion in age-related macular degeneration. Methods/Results A 64-year-old man had a complaint of metamorphopsia in the left eye. Visual acuity was 0.5 in the left eye. Fluorescein angiography and indocyanine angiography showed juxtafoveal occult choroidal neovascularization (CNV) in the left eye, and pegaptanib sodium 0.3 mg was administered once every 6 weeks. After 4 months, visual acuity improved to 0.8. After 8 months follow-up, optical coherence tomography (OCT) showed subretinal fluid (SRF) and retinal pigment epithelium (RPE) irregularity. Visual acuity was 0.4. We recommended further pegaptanib sodium injections, but the patient did not consent to the treatment. Onset of cellulitis of the left toe occurred 1 week before the scheduled visit after 9 months. The patient was treated with loxoprofen sodium (nonselective COX inhibitor) and cefdinir for 7 days. At 2 weeks after onset of cellulitis, SRF had disappeared and OCT showed improvement of RPE irregularity. Conclusions A COX inhibitor had an effect on vascular permeability in CNV and may have improved exudative changes.
Radiological Classification of Hip Arthropathy Associated with Long-Term Haemodialysis
Authors: Fukunishi Shigeo , Fukui Tomokazu , Nishio Shoji , Fujihara Yuki , Okahisa Shohei , Yoshiya Shinichi 
Published: July 2011

Various types of hip lesion associated with long-term haemodialysis have been observed. We present a new radiological classification system of haemodialysis-related hip arthropathy. In total, 103 hip lesions were analyzed in 84 patients undergoing haemodialysis for more than ten years. The hip lesions were classified into 3 types; Type I - cystic type with further subdivisions based on cyst location, Type II - arthritic type, and Type III - deformity of the femoral head. Surgery was performed on 60 hips. We believe our classification system assists decision making on behalf of these patients.
Role of Alpha-Fetoprotein in Selection of Patients with Hepatocellular Carcinoma Waiting for Liver Transplantation: Must we Reconsider it?
Authors: Lai Quirino , Avolio Alfonso W. , Manzia Tommaso M. , Agnes Salvatore , Tisone Giuseppe , Berloco Pasquale B. , Rossi Massimo 
Published: July 2011

Background Milan criteria (MC) represent the most commonly adopted criteria for the selection of patients with hepatocellular carcinoma (HCC) waiting for liver transplantation (LT). However, MC are exclusively based on morphological aspects. The aim of the present study was to evaluate pre-LT–detectable biological parameters, to compare them with morphological ones in terms of tumor recurrence prediction and patient survival. Methods A cohort of 153 consecutive adult patients who underwent LT for HCC on cirrhosis from January 1999 to March 2009 was retrospectively analyzed. Results HCC recurrence was observed in 12 patients (7.8%). At multivariate logistic regression analysis, serum alpha-fetoprotein (AFP) was the unique independent negative risk factor for the development of HCC recurrence (odds ratio 2.0, p=0.03). Adopting a cutoff value of 210 ng/mL, patients who presented serum AFP ≥210 ng/mL showed a 5-year survival rate of 23.3% versus 76.2% observed in patients with pre-LT serum AFP <210 ng/mL (log-rank test: <0.0001). Conclusions In our experience, AFP was the strongest predictor of HCC recurrence, stronger than tumor morphology. AFP could ameliorate the selection of LT candidates. Further studies to evaluate the combination of morphological and biological criteria are needed.
Orthopedic resident anatomy review course: A collaboration between anatomists and orthopedic surgeons
Authors: DeFriez Curtis B. , Morton David A. , Horwitz Daniel S. , Eckel Christine M. , Foreman K. Bo , Albertine Kurt H. 
Published: July 2011

AbstractA challenge for new residents and senior residents preparing for board examinations is refreshing their knowledge of basic science disciplines, such as human gross anatomy. The Department of Orthopaedics at the University of Utah School of Medicine has for many years held an annual Orthopedic Resident Anatomy Review Course during the summer months for all of its residents. The primary purpose of the course is to renew competencies in basic science disciplines so that incoming residents more quickly reach a level of functional proficiency and to afford senior residents a platform to teach their junior colleagues. Before 2005, this course was conducted with minimal participation from anyone outside of the Department of Orthopaedics. Many of the residents voiced concerns that the educational benefits were not proportionate to the time invested. To improve the teaching of orthopedic‐related anatomy, an educational collaboration between the Departments of Neurobiology and Anatomy and Orthopaedics was established in 2004 and continues to the present time. The major objectives of refining the course pedagogy, developing a Course Manual and Dissection Guide, and evaluating the results by administering a course survey questionnaire are described in this article. Implementation of all facets of the revised course has resulted in better participation by orthopedic faculty and more favorable reviews by the participating residents. Based on current levels of interest and positive comments from course participants, the Anatomy and Orthopedic faculty course directors plan to continue to develop course materials and pedagogy. Anat Sci Educ. © 2011 American Association of Anatomists.
In vivo ultra‐fast photoacoustic flow cytometry of circulating human melanoma cells using near‐infrared high‐pulse rate lasers
Authors: Nedosekin Dmitry A. , Sarimollaoglu Mustafa , Ye Jian‐Hui , Galanzha Ekaterina I. , Zharov Vladimir P. 
Published: July 2011

AbstractThe circulating tumor cells (CTCs) appear to be a marker of metastasis development, especially, for highly aggressive and epidemically growing melanoma malignancy that is often metastatic at early stages. Recently, we introduced in vivo photoacoustic (PA) flow cytometry (PAFC) for label‐free detection of mouse B16F10 CTCs in melanoma‐bearing mice using melanin as an intrinsic marker. Here, we significantly improve thespeed of PAFC by using a high‐pulse repetition rate laser operating at 820 and 1064 nm wavelengths. This platform was used in preclinical studies for label‐free PA detection of low‐pigmented human CTCs. Demonstrated label‐free PAFC detection, low level of background signals, and favorable safety standards for near‐infrared irradiation suggest that a fiber laser operating at 1064 nm at pulse repetition rates up to 0.5 MHz could be a promising source for portable clinical PAFC devices. The possible applications can include early diagnosis of melanoma at the parallel progression of primary tumor and CTCs, detection of cancer recurrence, residual disease and real‐time monitoring of therapy efficiency by counting CTCs before, during, and after therapeutic intervention. Herewith, we also address sensitivity of label‐free detection of melanoma CTCs and introduce in vivo CTC targeting by magnetic nanoparticles conjugated with specific antibody and magnetic cells enrichment. © 2011 International Society for Advancement of Cytometry
Modular anti‐EGFR and anti‐Her2 targeting of SK‐BR‐3 and BT474 breast cancer cell lines in the presence of ErbB receptor‐specific growth factors
Authors: Diermeier‐Daucher Simone , Breindl Stefanie , Buchholz Stefan , Ortmann Olaf , Brockhoff Gero 
Published: July 2011

AbstractOver the last decade, a number of monoclonal antibodies and small molecule inhibitors emerged as potent therapeutic agents in the treatment of Her2/neu overexpressing breast cancer. Numerous patients, however, do not adequately respond to anti‐epidermal growth factor receptor (EGFR)/Her2 receptor targeting. Receptor‐ and, in turn, growth‐stimulating effects, which potentially hamper antiproliferative cell treatment, have barely been investigated. BT474 and SK‐BR‐3 breast cancer cell lines were treated with Trastuzumab, Pertuzumab, and Lapatinib alone using different combinations and concentrations. Moreover, epidermal growth factor (EGF) or heregulin (HRG) was added to reveal potential growth factor‐mediated compensatory effects. Receptor and intracellular signaling were analyzed as a function of cell treatment. Read‐out parameters were cell proliferation and apoptosis. BT474 cells were efficiently driven into quiescence by Trastuzumab, but not by Pertuzumab treatment. Simultaneous EGF or HRG administration, however, restored the BT474 cell proliferation capacity. In contrast, neither therapeutic antibody treatment caused a profound inhibition of SK‐BR‐3 cell‐cycle progress. Lapatinib turned out to be the most potent cell‐cycle inhibitor in both cell lines even though its impact was significantly abrogated in the presence of EGF and HRG. The compensatory effect of EGF on Lapatinib‐induced cell‐cycle inhibition was reversed by Trastuzumab as well as by Pertuzumab treatment. Most importantly, HRG‐caused compensation of Lapatinib‐induced cell‐cycle exit was reversed by Pertuzumab but not by Trastuzumab. Apparently, multiple anti‐EGFR/Her2 targeting by using Trastuzumab, Pertuzumab, and Lapatinib more efficiently affects receptor function (interaction and activation) and consequently enhances their antiproliferative capacity. Growth inhibition by anticancer drugs targeted to Her/ErbB receptors, however, can be significantly undermined in the presence of EGF and in particular by HRG treatment, which suggests that specific therapeutic growth factor sequestration might further enhance anti‐EGFR/Her2 targeting. © 2011 International Society for Advancement of Cytometry
Estimating the future decline of wild coho salmon populations resulting from early spawner die-offs in urbanizing watersheds of the Pacific Northwest, USA
Authors: Spromberg Julann A , Scholz Nathaniel L 
Published: July 2011

Abstract
Since the late 1990s, monitoring efforts evaluating the effectiveness of urban stream restoration projects in the greater metropolitan area of Seattle, Washington, USA, have detected high rates of premature mortality among adult coho salmon (Oncorhynchus kisutch) in restored spawning habitats. Affected animals display a consistent suite of symptoms (e.g., disorientation, lethargy, loss of equilibrium, gaping, fin splaying) that ultimately progresses to death on a timescale of a few hours. Annual rates of prespawn mortality observed over multiple years, across several drainages, have ranged from approximately 20% to 90% of the total fall run within a given watershed. Current weight-of-evidence suggests that coho prespawn mortality is caused by toxic urban stormwater runoff. To evaluate the potential consequences of current and future urbanization on wild coho salmon, we constructed life-history models to estimate the impacts of prespawn mortality on coho populations and metapopulations. At the low (20%) and high (90%) ends of the range of observed mortality, model results indicated the mean time to extinction of localized coho populations in 115 and 8 y, respectively. The presence of productive source populations (i.e., unaffected by prespawn mortality) within a metapopulation reduced local extinction risk. However, as more populations within a metapopulation become affected by spawner die-offs prior to spawning, the source population's productivity declined. These simple models demonstrate the potential for rapid losses from coho populations in urbanizing watersheds. Because the models do not account for possible impacts of toxic runoff to other coho life stages, they likely underestimate the cumulative impacts of nonpoint source pollution on wild populations. Integr Environ Assess Manag 2011;7:648–656. © 2011 SETAC
Development of a self‐report instrument to assess social and emotional development
Authors: Seal Craig R. , Beauchamp Kenneth L. , Miguel Krystal , Scott Amy N. 
Published: July 2011

AbstractThe authors present a revised model and a new measure of social and emotional development in higher education. They describe the psychometric properties of the measure, using a sample of 632 freshman students at a small private university. Social emotional development is defined as the enhancement of individual capacity to recognize and regulate emotional information and behaviors to facilitate desirable social outcomes. The analysis of the Social Emotional Development Inventory indicates the current instrument has an appropriate factor structure and adequate internal consistency. Recommendations for future versions of the instrument are included.
A comparative analysis of affirmative action in the United Kingdom and United States
Authors: Archibong Uduak , Sharps Phyllis W. 
Published: July 2011

AbstractBased on research conducted during a large‐scale European Commission project on international perspectives on positive/affirmative action measures, the authors provide a comparative analysis of the legal context and perceptions of the impact of positive action in the United Kingdom and the United States. The study adopted participatory methods including consensus workshops, interviews, and legal analysis to obtain data from those individuals responsible for designing and implementing positive action measures. Findings are discussed, conclusions drawn, and wide‐ranging recommendations are made at governmental and organizational levels. The authors conclude by suggesting possible implications for policy and argue for widespread awareness‐raising campaigns of both the need for positive action measures for disadvantaged groups and the benefits of such measures for wider society. They also recommend the adoption of a more coherent and collaborative approach to the utilization and evaluation of the effectiveness of positive or affirmative action.
Youth development and the camp experience
Authors: Garst Barry A. , Browne Laurie P. , Bialeschki M. Deborah 
Published: July 2011

AbstractGrowth in the volume and rigor of camp research over the past decade has led to improved understanding of the value of the camp experience as a setting for positive youth development and the developmental outcomes of camp experiences for youth and adults, suggesting innovations and opportunities in the exploration of the camp experience.
Clostridium beijerinckii mutant with high inhibitor tolerance obtained by low-energy ion implantation
Authors: Guo Ting , Tang Yan , Zhang Qiu-yan , Du Teng-fei , Liang Da-feng , Jiang Min , Ouyang Ping-kai 
Published: July 2011

Abstract
Clostridium beijerinckii mutant strain IB4, which has a high level of inhibitor tolerance, was screened by low-energy ion implantation and used for butanol fermentation from a non-detoxified hemicellulosic hydrolysate of corn fiber treated with dilute sulfuric acid (SAHHC). Evaluation of toxicity showed C. beijerinckii IB4 had a higher level of tolerance than parent strain C. beijerinckii NCIMB 8052 for five out of six phenolic compounds tested (the exception was vanillin). Using glucose as carbon source, C. beijerinckii IB4 produced 9.1 g l−1 of butanol with an acetone/butanol/ethanol (ABE) yield of 0.41 g g−1. When non-detoxified SAHHC was used as carbon source, C. beijerinckii NCIMB 8052 grew well but ABE production was inhibited. By contrast, C. beijerinckii IB4 produced 9.5 g l−1 of ABE with a yield of 0.34 g g−1, including 2.2 g l−1 acetone, 6.8 g l−1 butanol, and 0.5 g l−1 ethanol. The remarkable fermentation and inhibitor tolerance of C. beijerinckii IB4 appears promising for ABE production from lignocellulosic materials.
The strong minimum principle for quasisuperminimizers of non-standard growth
Authors: Harjulehto P. , Hästö P. , Latvala V. , Toivanen O. 
Published: July 2011

We prove the strong minimum principle for non-negative quasisuperminimizers of the variable exponent Dirichlet energy integral under the assumption that the exponent has modulus of continuity slightly more general than Lipschitz. The proof is based on a new version of the weak Harnack estimate.

Résumé
Nous prouvons le fort principe du minimum pour des quasisuperminimizeurs non-négatifs de problème de Dirichlet de lʼexposant variable en supposant que lʼexposant a le module de continuité un peu plus général que Lipschitz. La démonstration est fondée sur une nouvelle version de la faible inégalité de Harnack.
Epigenetic, transcriptional and posttranscriptional regulation of the tyrosine hydroxylase gene
Authors: Lenartowski Robert , Goc Anna 
Published: July 2011

AbstractThe activity of tyrosine hydroxylase (TH, EC 1.14.16.2) gene and protein determines the catecholamine level, which, in turn, is crucial for the organism homeostasis. The TH gene expression is regulated by near all possible regulatory mechanisms on epigenetic, transcriptional and posttranscriptional levels. Ongoing molecular characteristic of the TH gene reveals some of the cis and trans elements necessary for its proper expression but most of them especially these responsible for tissue specific expression remain still obscure. This review will focus on some aspects of TH regulation including spatial chromatin organization of the TH locus and TH gene, regulatory elements mediating basal, induced and cell‐specific activity, transcriptional elongation, alternative TH RNA processing, and the regulation of TH RNA stability in the cell.
Modeling Alzheimer's disease progression using the disease system analysis approach
Authors: Gomeni Roberto , Simeoni Monica , Zvartau‐Hind Marina , Irizarry Michael C. , Austin Daren , Gold Michael 
Published: July 2011

AbstractA novel mechanistic model based on a disease system analysis paradigm was developed to explore the role of homeostatic mechanisms involved in Alzheimer's disease (AD) progression. We used longitudinal AD Assessment Scale‐cognitive subscale (ADAS‐cog) scores from 926 subjects with AD on stable acetylcholinesterase inhibitor therapy randomized to placebo treatment in two 54‐week clinical trials. Alternative mechanistic models were evaluated by assuming that the rate of change of ADAS‐cog over time was jointly regulated by a process characterizing the deterioration of ADAS‐cog and by a process associated with a compensatory regulatory response. The model based on a time‐varying deterioration rate of ADAS‐cog performed better than the model based on a time‐varying homeostatic control. The covariate analysis indicated that baseline Mini‐Mental State Examination score, education, age, and apolipoprotein ε4 genotype had a significant effect on the level and shape of the trajectories of the mean model predicted ADAS‐cog change from baseline.
Enhanced active choice: A new method to motivate behavior change
Authors: Keller Punam Anand , Harlam Bari , Loewenstein George , Volpp Kevin G. 
Published: July 2011

AbstractHigh rates of medication non‐adherence have significant public health and economic consequences. In other contexts such as savings behavior, opt‐out policies, in which the alternative preferred by the policy maker is made the default, have gotten great traction but may not be feasible in health care settings. After reviewing previous applications, we present a series of studies, including two field experiments, that test the effectiveness of an alternative, ‘active choice’ policy in which there is no default, but decision makers are required to make a choice (Carroll, Choi, Laibson, Madrian, & Metrick, 2009; Spital, 1993, 1995). In addition, we propose and test a modified version of active choice, that we call ‘enhanced active choice’ that favors one alternative by highlighting losses incumbent in the in the non‐preferred alternative. We recommend Enhanced Active Choice as a complement to automatic enrollment or when automatic enrollment is infeasible or unethical.
Prevalence of Prostate Cancer in Patients With Chronic Spinal Cord Injury
Authors: Patel Nikhil , Ngo Kenneth , Hastings James , Ketchum Nicholas , Sepahpanah Farhad 
Published: July 2011

ObjectiveTo determine the prevalence of prostate cancer in patients with chronic spinal cord injury (SCI), with regard to the duration, level, and severity of injury.DesignRetrospective chart review study.SettingInpatient and outpatient Veterans Affairs spinal cord unit.ParticipantsThe electronic medical records of 350 veterans with chronic SCI and 344 veterans without SCI as a control group were reviewed.Main Outcome MeasurePrevalence of prostate cancer in patients with chronic SCI with regard to the duration, level, and severity of injury.ResultsOf 350 veterans with chronic SCI, 7 individuals (2%) had prostate cancer. In comparison, of 344 age‐matched veterans without SCI, 18 (5.2%) had prostate cancer. In SCI group with prostate cancer, 2 patients had motor complete injury (American Spinal Cord Injury Association Impairment Scale [AIS] A and B), and 5 patients had motor incomplete injury (AIS C, D, and E). Patients with SCI and with prostate cancer were slightly older (mean [SD] age, 72.14 ± 8.25 years) than the control group (mean [SD] age, 69.83 ± 8.79 years) with cancer.ConclusionFindings from this study indicate a lower prevalence of prostate cancer among veterans with chronic SCI in comparison with age‐matched veterans without SCI. Given the small number of patients with SCI and with prostate cancer in this study, we did not find any statistically significant correlation between the prevalence of prostate cancer and the level, duration, and severity of injury.