bluuebunny/crossref_metadata_2025_split huggingface dataset:
Chronic ACLD Knees with Early Developmental Cartilage Lesions Exhibited Increased Posterior Tibial Translation during Level Walking
Authors: Zeng Xiaolong , Lin Fangzheng , Huang Wenhan , Kong Lingchuang , Zeng Jiajun , Guo Da , Zhang Yu , Lin Dingkun 
Published: May 2024

ObjectiveEarly articular cartilage lesion (CL) is a vital sign in the onset of posttraumatic knee osteoarthritis (PTOA) in patients with anterior cruciate ligament deficiency (ACLD). Researchers have suggested that altered kinematics could accelerate CLs and, therefore, lead to the onset of PTOA. However, little is known about whether specific knee kinematics exist that lead to early CL in chronic ACLD knees. Level walking is the most frequent and relevant in vivo activity, which greatly impacts knee health. We hypothesized that the knee kinematics during level walking in chronic ACLD knees with early tibiofemoral CL would significantly differ from those of chronic ACLD knees without early tibiofemoral CL.MethodsThirty patients with a chronic ACLD history, including 18 subjects with CLs and 12 subjects without CLs, and 35 healthy control subjects were recruited for the study from July 2020 to August 2022. The knee kinematic data during level walking were collected using a three‐dimensional motion analysis system. The kinematic differences between groups were compared using statistical parametric mapping with one dimension for One‐Way ANOVA. The cartilage statuses of the ACLD knees were assessed via MRI examination. The CLs distribution of subjects was evaluated using a modified Noyes scale and analyzed by chi‐square tests.ResultsACLD knees with CLs had significantly greater posterior tibial translation (7.7–8.0mm, 12%–18% gait cycle GC, p = 0.014) compared to ACLD knees without CLs during level walking. ACLD knees with CLs had greater posterior tibial translation (4.6–5.5mm, 0%–23% GC, p < 0.001; 5.8–8.0mm, 86%–100% GC, p < 0.001) than healthy controls during level walking. In the group of ACLD knees with CLs, CL is mainly located in the back of the tibia plateau and front of load bearing area of the medial femoral condyle (p < 0.05).ConclusionChronic anterior cruciate ligament deficient knees with cartilage lesions have increased posterior tibial translation compared to anterior cruciate ligament deficient knees without cartilage lesions and healthy subjects. The posterior tibial translation may play an important role in knee cartilage degeneration in ACLD knees. The increased posterior tibial translation and cartilage lesion characteristics may improve our understanding of the role of knee kinematics in cartilage degeneration and could be a helpful potential reference for anterior cruciate ligament deficient therapy, such as physical training to improve abnormal kinematic behavior.
Initial quantitative assessment of the enigmatic clade Paracrinoidea (Echinodermata)
Authors: Limbeck Maggie R. , Bauer Jennifer E. , Deline Bradley , Sumrall Colin D. 
Published: May 2024

AbstractGreat strides have been made in understanding the phylogeny of the five extant echinoderm classes, however, many Palaeozoic groups have yet to be examined in a rigorous, quantitative framework. The aberrant morphologies of Paracrinoidea, an unusual group of Palaeozoic echinoderms, have hindered their inclusion in large‐scale phylogenetic and morphologic studies. This study uses a combined approach of phylogenetic analysis and morphological disparity to elucidate species relationships within the clade. Findings from this study suggest that Paracrinoidea is a monophyletic group and that respiratory structures, oral plate arrangement, and ambulacral morphologies are important for defining subclades within Paracrinoidea. Examination of paracrinoids in a quantitative framework, facilitates their inclusion in larger projects examining Palaeozoic echinoderm evolution, ecology and biogeography.
Astaxanthin attenuates UV‐irradiation aging process via activating JNK‐1/DAF‐16 in Caenorhabditis elegans
Authors: Lin Xiuping , Shao Chang‐sheng , Elsherbiny Shereen M. , Huang Qing 
Published: May 2024

AbstractAstaxanthin (AST) is a xanthophyll carotenoid with strong oxidation resistance, which can effectively scavenge various free radicals and protect organisms from oxidative damage. AST is also known to have prominent anti‐aging effects, but the underlying mechanism of AST in anti‐radiation aging is largely unknown. In this work, we applied ultraviolet (UV) irradiation to accelerate the aging of Caenorhabditis elegans (C. elegans) and treated the nematodes with AST to explore whether and how AST could attenuate the radiation‐induced aging effect. Our results showed that AST improved the survival rate of C. elegans, reduced the aging biomarkers, and alleviated the mitochondrial dysfunction caused by the irradiation. Based on the transcriptome sequencing analysis, we identified that the key genes regulated by AST were involved in JNK‐MAPK and DAF‐16 longevity signaling pathways. Furthermore, we employed jnk‐1 and daf‐16 mutants and verified the role of the JNK‐1/DAF‐16 signaling pathway in the anti‐aging effect. As such, this study has not only demonstrated that AST can resist the aging process caused by UV‐irradiation but also revealed the anti‐aging mechanism of AST through JNK‐1/DAF‐16 activation in C. elegans.
Why prevent human extinction?
Authors: Fanciullo James 
Published: May 2024

AbstractMany of us think human extinction would be a very bad thing, and that we have moral reasons to prevent it. But there is disagreement over what would make extinction so bad, and thus over what grounds these moral reasons. Recently, several theorists have argued that our reasons to prevent extinction stem not just from the value of the welfare of future lives, but also from certain additional values relating to the existence of humanity itself (for example, humanity's “final” value, or the value of humanity in itself). In this paper, I argue against these “additional value” views. Despite their initial appeal, these views will inevitably face conflicts between the additional values to which they appeal, and the value of the welfare of future lives. And, I argue, the views cannot plausibly resolve these conflicts. In contrast, these conflicts do not arise for a rival view, on which our reasons to prevent extinction stem just from the value of the welfare of future lives. I conclude that this gives us reason to prefer the latter view, despite the greater initial plausibility of additional value views.
The neural correlates of reinforcement sensitivity theory: A systematic review of the frontal asymmetry and spectral power literature
Authors: Firth Jennifer , Standen Bradley , Sumich Alexander , Fino Emanuele , Heym Nadja 
Published: May 2024

AbstractThe original Reinforcement Sensitivity Theory (oRST) proposes two systems of approach (BAS) and avoidance (BIS) motivation to underpin personality and behavior. The revised‐RST (rRST) model separates avoidance motivation into passive (BIS; anxiety) and active (FFFS; fear) systems. Prior research has attempted to map RST onto lateralized frontal asymmetry to provide a neurophysiological marker of RST. The main aim is to examine the relationships of the o/rRST scales with trait (baseline) and state (manipulated through experimental paradigms) frontal asymmetry. A systematic review was conducted, resulting in 158 studies designated to neuroimaging research. In total, 54 studies were included in this review using either frontal asymmetry or spectral power. The results were split into three main categories: resting frontal alpha asymmetry (N = 23), emotional induction and state‐related frontal alpha asymmetry (N = 20), and spectral analysis (N = 16). Findings indicated that BAS was associated with enhanced left frontal asymmetry at baseline and during state‐related paradigms. Findings for BIS were more inconsistent, especially at rest, suggesting that BIS, in particular, may require active engagement with the environment. Only 9 of the 54 papers included used the revised RST model, highlighting the need for more rRST research.
Diffuse idiopathic skeletal hyperostosis (DISH): Detection on dental radiologic examinations in two older adults and overview of the literature
Authors: Brooks John K. , Parsa Azin , Craig Jessica S. , Bell Shereese , Song Julia , Varlotta Sharon L. , Price Jeffery B. 
Published: May 2024

AbstractBackgroundDiffuse idiopathic skeletal hyperostosis (DISH) is a potentially serious osteopathic disorder associated with coalescing ossifications of the anterior vertebrae and may be concomitant with a constellation of symptomatology and systemic comorbidities. There is limited dental literature describing this finding on panoramic radiographs and cone beam computed tomography (CBCT) scans.Case presentationsTwo case reports of DISH are provided. One patient manifested extensive ossifications along the cervical vertebrae and consequent episodes of dysphagia and hoarseness. The other affected patient's cervical ossification was found at an earlier stage of formation and without symptomatology. Panoramic radiography, cervical spine radiography, and CBCT examinations have been provided.ConclusionAttending dental healthcare practitioners should carefully evaluate all areas of interest and surrounding fields of view when taking panoramic radiographs and CBCT scans for manifestations of DISH and other potential disorders of the cervical vertebrae. A suspected radiologic finding of DISH should prompt timely referral for comprehensive medical assessment to mitigate neurologic deficits and other comorbidities.
Oral health status of prisoners in India: A systematic review and meta‐analysis
Authors: Mehta Vini , Tripathy Snehasish , Shamim Muhammad Aaqib , Sarode Gargi S. , Rizwan S. A. , Mathur Ankita , Sarode Sachin C. 
Published: May 2024

AbstractAimsGiven the high prevalence of oral health problems among prisoners, the goal of this systematic review is to provide a better knowledge of the scope of this problem.MethodsElectronic searches of PubMed/MEDLINE, Embase, Scopus, and Google Scholar were performed. Studies that investigated inmates aged 18 or older with oral health problems were eligible. Variables reported in four or less studies were described narratively. Conversely, for variables reported in more than four studies, a meta‐analysis was performed using random effect model. Furthermore, meta‐regression and sensitivity analysis is also performed to evaluate moderator effect on outcome. Doi and LFT index is applied to assess publication bias.ResultsOut of 494 results, 12 studies were included. The pooled prevalence of caries among prisoners is 78.42% (59.48%–92.58%). On meta‐regression, the prevalence of caries appears to be lower in studies with a higher male percentage; however, non‐significant (p = .079) due to small sample size. Community periodontal index (CPI) scores revealed periodontal disease, with scores of 3 and 4. Moreover, a significant need for oral hygiene instruction, prosthesis, extraction, and tooth ache, periodontal disease, oral mucosal lesions, leucoplakia, attrition, abrasion, bruxism, and smoking behaviors were also reported.ConclusionPoor oral health status in the incarcerated population highlights the urgent need for comprehensive oral health intervention in prisons.
Data‐bility: Endogamous social intimacies on dating apps in Mumbai
Authors: Dattani Kavita 
Published: May 2024

AbstractIn this paper I argue through the double entendre of ‘data‐bility’ that how dateable one is on a dating app relies on data. This techno‐social framework enables an understanding of how dating apps are reconfiguring a politics of sexuality, circumscribed by digital technologies and data. Drawing on research with middle‐class women and gender‐minority dating app users in Mumbai and one dating app executive, the paper investigates how algorithms and users' digital behaviour together constitute data‐bility in three ways. First, dating app algorithms are designed to match those of similar social identities to one another. Second, dating app users engage with others' digital data on profiles and through message chats, reading class through these processes, deciding who to match/reject and correspondingly who is data‐ble. Third, users and algorithmic infrastructures come together to create new regimes of verification, through deeming some users ‘real’ and others ‘fake’ on dating apps, extending violent legacies of categorisation. Together, these processes result in data‐bility, a techno‐social order of digital dating oriented around the exclusion of those labelled ‘creeps’ along class and caste lines.
Tripartite motif 2b (
trim2b
) restricts spring viremia of carp virus by degrading viral proteins and negative regulators NLRP12-like receptors
Authors: Fang Hong , Wu Xiao Man , Zheng Si Yao , Chang Ming Xian 
Published: May 2024

ABSTRACT

Tripartite motif (TRIM) proteins are involved in different cellular functions, including regulating virus infection. In teleosts, two orthologous genes of mammalian TRIM2 are identified. However, the functions and molecular mechanisms of piscine TRIM2 remain unclear. Here, we show that
trim2b
-knockout zebrafish are more susceptible to spring viremia of carp virus (SVCV) infection than wild-type zebrafish. Transcriptomic analysis demonstrates that NOD-like receptor (NLR), but not RIG-I-like receptor (RLR), signaling pathway is significantly enriched in the
trim2b
-knockout zebrafish.
In vitro
, overexpression of Trim2b fails to degrade RLRs and those key proteins involved in the RLR signaling pathway but does for negative regulators NLRP12-like proteins. Zebrafish Trim2b degrades NLRP12-like proteins through its NHL_TRIM2_like and IG_FLMN domains in a ubiquitin-proteasome degradation pathway. SVCV-N and SVCV-G proteins are also degraded by NHL_TRIM2_like domains, and the degradation pathway is an autophagy lysosomal pathway. Moreover, zebrafish Trim2b can interfere with the binding between NLRP12-like protein and SVCV viral RNA and can completely block the negative regulation of NLRP12-like protein on SVCV infection. Taken together, our data demonstrate that the mechanism of action of zebrafish
trim2b
against SVCV infection is through targeting the degradation of host-negative regulators NLRP12-like receptors and viral SVCV-N/SVCV-G genes.

IMPORTANCE

Spring viremia of carp virus (SVCV) is a lethal freshwater pathogen that causes high mortality in cyprinid fish. In the present study, we identified zebrafish
trim2b
, NLRP12-L1, and NLRP12-L2 as potential pattern recognition receptors (PRRs) for sensing and binding viral RNA. Zebrafish
trim2b
functions as a positive regulator; however, NLRP12-L1 and NLRP12-L2 function as negative regulators during SVCV infection. Furthermore, we find that zebrafish
trim2b
decreases host lethality in two manners. First, zebrafish Trim2b promotes protein degradations of negative regulators NLRP12-L1 and NLRP12-L2 by enhancing K48-linked ubiquitination and decreasing K63-linked ubiquitination. Second, zebrafish
trim2b
targets viral RNAs for degradation. Therefore, this study reveals a special antiviral mechanism in lower vertebrates.
Complete genome sequence of
Lacticaseibacillus paracasei
A02
Authors: Li Jiahao , Wu Xiuyun , Xing Sheng , Ding Bo 
Published: May 2024

ABSTRACT

Lacticaseibacillus paracasei,
a facultative anaerobic gram-positive bacterium, is commonly found in the gut of humans and animals, as well as in dairy products and plant ferments. Here, we report the complete genome sequence of
L. paracasei
A02, whose total genome length is 3,038,472 bp, with a GC content of 46.41%.
Complete genome sequence of
Cellulomonas
sp. strain ATA003
Authors: Bartholomäus Alexander , Mitzscherling Julia , Lipus Daniel , Wagner Dirk , Lavin Paris , Contreras Roberto , Oses Rómulo 
Published: May 2024

ABSTRACT

The Gram-positive, rod-shaped endophytic bacterium
Cellulomonas
sp. strain ATA003 was isolated from the endemic cactus
Maihueniopsis domeykoensis
seeds collected in the Coastal Atacama Desert, Chile. Here, we present a circular genome with a size of 4,084,881 bp and a GC content of 73.8% obtained by Nanopore sequencing.
Profiling the interplay and coevolution of
Microcystis aeruginosa
and cyanosiphophage Mic1
Authors: Wang Xiao-Qian , Du Kang , Chen Chaoyi , Hou Pu , Li Wei-Fang , Chen Yuxing , Li Qiong , Zhou Cong-Zhao 
Published: May 2024

ABSTRACT

The cyanosiphophage Mic1 specifically infects the bloom-forming
Microcystis aeruginosa
FACHB 1339 from Lake Chaohu, China. Previous genomic analysis showed that its 92,627 bp double-stranded DNA genome consists of 98 putative open reading frames, 63% of which are of unknown function. Here, we investigated the transcriptome dynamics of Mic1 and its host using RNA sequencing. In the early, middle, and late phases of the 10 h lytic cycle, the Mic1 genes are sequentially expressed and could be further temporally grouped into two distinct clusters in each phase. Notably, six early genes, including
gp49
that encodes a TnpB-like transposase, immediately reach the highest transcriptional level in half an hour, representing a pioneer cluster that rapidly regulates and redirects host metabolism toward the phage. An in-depth analysis of the host transcriptomic profile in response to Mic1 infection revealed significant upregulation of a polyketide synthase pathway and a type III-B CRISPR system, accompanied by moderate downregulation of the photosynthesis and key metabolism pathways. The constant increase of phage transcripts and relatively low replacement rate over the host transcripts indicated that Mic1 utilizes a unique strategy to gradually take over a small portion of host metabolism pathways after infection. In addition, genomic analysis of a less-infective Mic1 and a Mic1-resistant host strain further confirmed their dynamic interplay and coevolution via the frequent horizontal gene transfer. These findings provide insights into the mutual benefit and symbiosis of the highly polymorphic cyanobacteria
M. aeruginosa
and cyanophages.

IMPORTANCE

The highly polymorphic
Microcystis aeruginosa
is one of the predominant bloom-forming cyanobacteria in eutrophic freshwater bodies and is infected by diverse and abundant cyanophages. The presence of a large number of defense systems in
M. aeruginosa
genome suggests a dynamic interplay and coevolution with the cyanophages. In this study, we investigated the temporal gene expression pattern of Mic1 after infection and the corresponding transcriptional responses of its host. Moreover, the identification of a less-infective Mic1 and a Mic1-resistant host strain provided the evolved genes in the phage-host coevolution during the multiple-generation cultivation in the laboratory. Our findings enrich the knowledge on the interplay and coevolution of
M. aeruginosa
and its cyanophages and lay the foundation for the future application of cyanophage as a potential eco-friendly and bio-safe agent in controlling the succession of harmful cyanobacterial blooms.
Long-eccentricity pacing of alluvial stratigraphic architecture in the Eocene Bighorn Basin, Wyoming, USA
Authors: Wang Youwei , Baars Timothy F. , Storms Joep E.A. , Martinius Allard W. , Gingerich Philip D. , Abels Hemmo A. 
Published: May 2024

Abstract
Alluvial stratigraphy builds up over geologic time under the complex interplay of external climatic and tectonic forces and internal stochastic processes. This complexity makes it challenging to attribute alluvial stratigraphic changes to specific factors. Geological records indicate pronounced and persistent climatic changes during the Phanerozoic, while the effects of these changes on alluvial stratigraphy remain insufficiently documented. We provide evidence for 405 k.y. long-eccentricity climate forcing of alluvial stratigraphy in the lower Eocene Willwood Formation of the Bighorn Basin, Wyoming (USA). Two ~90-m-thick intervals, characterized by a relative paucity of sand, dominance of sinuous-river channels, and floodplain sediments with better-developed paleosols, coincide with eccentricity maxima as determined through integrated stratigraphic methods. These intervals are interspersed with three contrasting intervals, marked by relatively high sand content, prevalent braided-river channels, and less-developed paleosols, corresponding to eccentricity minima. A comprehensive genetic model that integrates climate, source-to-sink system, and alluvial dynamics to explain these findings remains to be elucidated. Given the consistent presence of the 405 k.y. eccentricity cycle throughout Earth’s history, it is plausible to infer that its influence may be discernible across a wide array of alluvial stratigraphic records.
Along-Strike Morphologic Variations of the Kyushu-Palau Ridge at 13°–17° N and Their Tectonic Implications
Authors: Li Panfeng , Qin Xuwen , Zhang Yong , Shang Luning , Shi Xianyao , Hu Gang , Lu Kai , Hou Fanghui , Lv Wenchao , Liu Jia , Li Xia , Du Runlin , Cong Jingyi , Yang Yuan 
Published: May 2024

Abstract
The paper provides a detailed description of the topographical distribution characteristics, along-strike morphologic variations, and tectonic implications of the Kyushu-Palau Ridge (KPR) in the 13°–17° N regions. The description is based on multibeam bathymetric data that was recently collected in the mid-southern segment of KPR and its surrounding areas. The findings indicate that the KPR in the studied region comprises several discontinuous seamounts and seamount chains. Along the ridge running from east to west, there is significant variation in the topography of the seafloor. Visible on this ridge are numerous deep-sea depressions and apparent topographical discontinuities. Geological tectonic processes such as plate subduction and seafloor spreading largely determine the topography of the seafloor. During the beginning of the Parece Vela Basin (PVB) spreading, the pre-existing volcanic arcs fractured under east-west extensional stress, resulting in the development of prominent seamounts, sharp ridges, relief alternations, and rift basins in the KPR. The east-west stress was subsequently transmitted to the weak and inactive mid-ocean ridge in the West Philippine Basin (WPB), which was reactivated and resulted in an episode of magma-poor spreading during 30–26 Ma. This episode caused the KPR to move eastward, stretched, and destroyed its pre-existing structure.
A case of naltrexone-induced acute eosinophilic pneumonia
Authors: Abdelghany Youmna , Glick Danielle Renee , Cutler Todd 
Published: May 2024

Acute eosinophilic pneumonia (AEP) is a rare cause of acute respiratory failure. Clinical presentations can range from dyspnoea, fever and cough, to rapidly progressive and potentially fulminant respiratory failure. While its exact cause is often unknown, associations with inhalational injuries and exposures to new medications have been described.We report a case of a middle-aged, non-smoking man with a history of alcohol use disorder. He presented with 4 days of shortness of breath that started hours after taking injectable naltrexone (Vivitrol). The patient had rapidly worsening hypoxaemia, necessitating emergent bronchoscopy with transbronchial biopsies and bronchoalveolar lavage which showed 66% eosinophils. The patient was intubated for the procedure and unable to get extubated due to worsening hypoxaemic respiratory failure with high fractional inspired oxygen requirements. Chest radiograph showed worsening lung infiltrates and with a high index of suspicion for AEP, he was started empirically on methylprednisolone. He had rapid improvement in his respiratory status and was extubated on day 5 of admission then discharged on day 8. Histopathological examination confirmed acute/subacute eosinophilic pneumonia. A 3-week post-discharge follow-up chest radiograph confirmed the full resolution of pulmonary infiltrates.Naltrexone-induced AEP is rare, with only six other cases reported in the literature. Careful history taking and prompt evaluation for AEP are important given the potential for rapid progression to acute hypoxic respiratory failure and the excellent response to steroid treatment.