bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sulforaphane enhanced muscle growth by promoting lipid oxidation through modulating key signaling pathways
Authors: Zhang Rui , Chen Suqin , Zhao Feng , Wang Wei , Liu Dayu , Chen Lin , Bai Ting , Wu Zhoulin , Ji Lili , Zhang Jiamin 
Published: June 2024

Abstract
Sulforaphane (SFN) has shown diverse effects on human health and diseases. SFN was administered daily to C57BL/6J mice at doses of 1 mg/kg (SFN1) and 3 mg/kg (SFN3) for 8 weeks. Both doses of SFN accelerated body weight increment. The cross-sectional area and diameter of Longissimus dorsi (LD) muscle fibers were enlarged in SFN3 group. Triglyceride (TG) and total cholesterol (TC) levels in LD muscle were decreased in SFN groups. RNA sequencing results revealed that 2455 and 2318 differentially expressed genes (DEGs) were found in SFN1 and SFN3 groups, respectively. Based on GO enrichment analysis, 754 and 911 enriched GO terms in the SFN1 and SFN3 groups, respectively. KEGG enrichment analysis shown that one KEGG pathway was enriched in the SFN1 group, while six KEGG pathways were enriched in the SFN3 group. The expressions of nine selected DEGs validated with qRT-PCR were in line with the RNA sequencing data. Furthermore, SFN treatment influenced lipid and protein metabolism related pathways including AMPK signaling, fatty acid metabolism signaling, cholesterol metabolism signalling, PPAR signaling, peroxisome signaling, TGFβ signaling, and mTOR signaling. In summary, SFN elevated muscle fibers size and reduced TG and TC content of in LD muscle by modulating protein and lipid metabolism-related signaling pathways.
Exploring galactic properties with machine learning
Authors: Zeraatgari F. Z. , Hafezianzadeh F. , Zhang Y.-X. , Mosallanezhad A. , Zhang J.-Y. 
Published: June 2024

Aims. We explore machine learning techniques to forecast the star-formation rate, stellar mass, and metallicity across galaxies with redshifts ranging from 0.01 to 0.3.
Methods. Leveraging CatBoost and deep learning architectures, we utilised multiband optical and infrared photometric data from SDSS and AllWISE trained on the SDSS MPA-JHU DR8 catalogue.
Results. Our study demonstrates the potential of machine learning to accurately predict galaxy properties solely from photometric data. We achieved minimised root mean square errors specifically by employing the CatBoost model. For the star-formation rate prediction, we attained a value of RMSESFR = 0.336 dex, while for the stellar mass prediction, the error was reduced to RMSESM = 0.206 dex. Additionally, our model yields a metallicity prediction of RMSEmetallicity = 0.097 dex.
Conclusions. These findings underscore the significance of automated methodologies in efficiently estimating critical galaxy properties amid the exponential growth of multi-wavelength astronomy data. Future research may focus on refining machine learning models and expanding datasets for even more accurate predictions.
Follow-up LOFAR observations of the τ Boötis exoplanetary system
Authors: Turner Jake D. , Grießmeier Jean-Mathias , Zarka Philippe , Zhang Xiang , Mauduit Emilie 
Published: June 2024

Context. Observing the radio emission from exoplanets is among the most promising methods to detect their magnetic fields and a measurement of an exoplanetary magnetic field will help constrain the planet’s interior structure, star-planet interactions, atmospheric escape and dynamics, and habitability. Recently, circularly polarized bursty and slow emission from theτBoötis (τBoo) exoplanetary system was tentatively detected using LOFAR (LOW-Frequency ARray) beamformed observations. If confirmed, this detection will be a major contribution to exoplanet science. However, follow-up observations are required to confirm this detection.Aims. Here, we present such follow-up observations of the τ Boo system using LOFAR. These observations cover 70% of the orbital period of τ Boo b including the orbital phases of the previous tentative detections.Methods. We used theBOREALISpipeline to mitigate radio frequency interference and to search for bursty and slowly varying radio signals.BOREALISwas previously used to find the tentative radio signals from τ Boo.Results. Our new observations do not show any signs of bursty or slow emission from the τ Boötis exoplanetary system.Conclusions. The cause for our non-detection is currently degenerate. It is possible that the tentative radio signals were an unknown instrumental systematic or that we are observing variability in the planetary radio emission due to changes in its host star. More radio data (preferably multi-site) and ancillary observations (e.g. magnetic maps) are required to further investigate the potential radio emission from the τ Boötis exoplanetary system.
The Spectra of IceCube Neutrino (SIN) candidate sources
Authors: Rodrigues X. , Karl M. , Padovani P. , Giommi P. , Paiano S. , Falomo R. , Petropoulou M. , Oikonomou F. 
Published: June 2024

Context. A correlation has been reported between the arrival directions of high-energy IceCube events and γ-ray blazars classified as intermediate- and high-synchrotron-peaked BL Lacs. Subsequent studies have investigated the optical properties of these sources, compiled and analyzed public multiwavelength data, and constrained their individual neutrino emission based on public IceCube point-source data.
Aims. We provide a theoretical interpretation of public multiwavelength and neutrino point source data for the 32 BL Lac objects in the sample previously associated with an IceCube alert event. We combined the individual source results to draw conclusions regarding the multimesssenger properties of the sample and the required power in relativistic protons.
Methods. We performed particle interaction modeling using open-source numerical simulation software. We constrained the model parameters using a novel and unique approach that simultaneously describes the host galaxy contribution, the observed synchrotron peak properties, the average multiwavelength fluxes, and, where possible, the IceCube point source constraints.
Results. We show that a single-zone leptohadronic model can describe the multiwavelength broadband fluxes from all 32 IceCube candidates. In some cases, the model suggests that hadronic emission may contribute a considerable fraction of the γ-ray flux. The required power in relativistic protons ranges from a few percent to a factor of ten of the Eddington luminosity, which is energetically less demanding compared to other leptohadronic blazar models in recent literature. The model can describe the 68% confidence level IceCube flux for a large fraction of the masquerading BL Lacs in the sample, including TXS 0506+056; whereas, for true BL Lacs, the model predicts a low neutrino flux in the IceCube sensitivity range. Physically, this distinction is due to the presence of photons from broad line emission in masquerading BL Lacs, which increase the efficiency of hadronic interactions. The predicted neutrino flux peaks between a few petaelectronvolt and 100 PeV and scales positively with the flux in the gigaelectronvolt, megaelectronvolt, X-ray, and optical bands. Based on these results, we provide a list of the brightest neutrino emitters, which can be used for future searches targeting the 10–100 PeV regime.
Genito-pelvine Schmerzstörung (Penetrationsstörung) – eine qualitative Interviewstudie zur Perspektive Betroffener auf die Versorgung im deutschen Gesundheitssystem
Authors: Wand Agnes 
Published: June 2024

Zusammenfassung
Einleitung Die genito-pelvine Schmerz-Penetrationsstörung (englische Abkürzung: GPPPD) hat eine hohe Prävalenz bei Menschen mit Vagina und stellt eine besondere Herausforderung für die medizinische Versorgung dar.
Forschungsziele Da es aktuell noch kein Wissen darüber gibt, wie Betroffene ihre gesundheitliche Versorgung in Deutschland erleben, wurden Menschen mit GPPPD hinsichtlich ihrer Erfahrungen im deutschen Gesundheitssystem befragt.
Methoden Personen mit GPPPD-Symptomen wurden in einer Physiotherapiepraxis und in Online-Selbsthilfe-Netzwerken rekrutiert. Es wurden halbstandardisierte Interviews durchgeführt, mit der qualitativen Inhaltsanalyse ausgewertet und kommunikativ validiert. Die acht Befragten waren zwischen 24 und 36 Jahren alt (Mittelwert: 30 Jahre). Die Themenfelder der Interviews bezogen sich auf den Zugang zu Diagnostik und Therapie, wahrgenommene Fachkenntnis, soziale Erfahrungen mit GPPPD in der Versorgung und deren Einfluss auf das soziale Leben sowie Wünsche hinsichtlich zukünftiger Versorgung.
Ergebnisse Innerhalb der medizinischen Regelversorgung wurde kaum Hilfe für Diagnostik und Therapie gefunden. Behandlungen wurden selten von ärztlichem Fachpersonal empfohlen und umfassten Psychotherapie, Physiotherapie und medikamentöse Interventionen. Eine ausbleibende Diagnosestellung konnte zu Hilflosigkeit dem Problem gegenüber sowie zu Isolation führen. Selbstständige Recherche wurde als Voraussetzung für den Zugang zu Diagnostik und Therapie berichtet. Soziale Komponenten der medizinischen Versorgung hatten einen hohen Stellenwert und die Erfahrungen wurden, neben Fachkenntnis, von Möglichkeiten zur Selbstbestimmung beeinflusst. Zusätzlich wurden heteronormativ geprägte Geschlechterrollen als problemverstärkend in medizinischer Versorgung und sozialem Leben identifiziert.
Schlussfolgerung Betroffene wünschen sich bessere Möglichkeiten, um qualitativ hochwertige Informationen über die Diagnose und Therapiemöglichkeiten erhalten zu können. Der Ausbau von gendersensiblen Ansätzen in der medizinischen Versorgung könnte Betroffene unterstützen. Die Ergebnisse sind nicht repräsentativ und es bedarf zukünftig weiterer Forschung, um Diagnose- und Behandlungsprozesse für GPPPD zu verbessern.
Prediction of Prognosis in Patients with Sepsis Based on
Platelet-Related Genes
Authors: Jiang Jing , Zhang Juan , Wang Ting , Yu Daihua , Ren Xiu 
Published: June 2024

AbstractThe study aimed to develop a risk prognostic model using platelet-related genes
(PRGs) to predict sepsis patient outcomes. Sepsis patient data from the Gene
Expression Omnibus (GEO) database and PRGs from the Molecular Signatures
Database (MSigDB) were analyzed. Differential analysis identified 1139
differentially expressed genes (DEGs) between sepsis and control groups. Gene
Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses
revealed enrichment in functions related to immune cell regulation and pathways
associated with immune response and infectious diseases. A risk prognostic model
was established using LASSO and Cox regression analyses, incorporating 10 PRGs
selected based on their association with sepsis prognosis. The model
demonstrated good stratification and prognostic effects, confirmed by survival
and receiver operating characteristic (ROC) curve analyses. It served as an
independent prognostic factor in sepsis patients. Further analysis using the
CIBERSORT algorithm showed higher infiltration of activated natural killer (NK)
cells and lower infiltration of CD8 T cells and CD4 T cells naïve in the
high-risk group compared to the low-risk group. Additionally, expression levels
of human leukocyte antigen (HLA) genes were significantly lower in the high-risk
group. In conclusion, the 10-gene risk model based on PRGs accurately predicted
sepsis patient prognosis and immune infiltration levels. This study provides
valuable insights into the role of platelets in sepsis prognosis and diagnosis,
offering potential implications for personalized treatment strategies.
Latest Developments on Palladium- and Nickel-Catalyzed Cross-Couplings Using Aryl Chlorides: Suzuki–Miyaura and Buchwald–Hartwig Reactions
Authors: Yamada Yoichi M. A. , Sen Abhijit 
Published: June 2024

AbstractPalladium- and nickel-catalyzed cross-couplings are powerful methods for constructing C–C and C–N bonds, particularly through Suzuki–Miyaura and Buchwald–Hartwig reactions. Although aryl iodides, bromides, and triflates are the most commonly used substrates, aryl chlorides are less frequently utilized due to their lower reactivity. However, they are appealing because they are readily available and inexpensive. This short review highlights recent developments on the Suzuki–Miyaura and Buchwald–Hartwig cross-couplings of aryl chlorides, using both homogeneous and heterogeneous catalysis with palladium and nickel.1	Introduction2	Suzuki–Miyaura Cross-Couplings2.1	Homogeneous Palladium Catalysis2.2	Heterogeneous Palladium Catalysis2.3	Homogeneous Nickel Catalysis2.4	Heterogeneous Nickel Catalysis3	Buchwald–Hartwig Amination Reactions3.1	Homogeneous Palladium Catalysis3.2	Heterogeneous Palladium Catalysis3.3	Homogeneous Nickel Catalysis3.4	Heterogeneous Nickel Catalysis4	Conclusion
Effect of zinc supplementation on the quality of cooled, stored equine sperm
Authors: Palacios Patricio D. , Ortiz Isabel , Dorado Jesús , Hidalgo Manuel , García Díaz Juan Ramón , Gambini Andrés 
Published: June 2024

Context Collecting, cooling, and cryopreserving semen is essential for accessing genetically superior stallions. However, preserving stallion sperm presents unique challenges compared with other species. Aims This study aimed to investigate the effect of zinc (Zn) supplementation on the quality of equine sperm during cold storage. Methods Various factors contributing to sperm quality were assessed at 24 and 48 h after cooling, and after subjecting the sperm samples to a heat-resistance test. In Experiment 1, four experimental groups were examined, each with different concentrations of Zn sulfate, as follows: 0, 1, 2, and 3 mM. Subsequently, Experiment 2 involved testing a wider range of concentrations (0, 0.1, 0.2, 0.4, 0.8, 1.6, and 3.2 mM), including evaluation of samples after incubation for 240 min at 37°C (heat-resistance test). Key results The addition of different concentrations of Zn to the extender INRA96 did not yield substantial improvements in sperm-quality parameters for cooling stallion semen after 24 or 48 h. Moreover, no protective benefits were observed when samples underwent a heat-resistance test. Concentrations of Zn surpassing 3 mM had an adverse effect on sperm-quality parameters. Conclusions and implications These findings have contributed to the understanding of Zn supplementation as a strategy for improving semen preservation in stallions.
Protective effect of curcumin on testicular damage caused by carbon tetrachloride exposure in rats
Authors: Bayramova Aysel , Keçeci Mete , Akpolat Meryem , Cengil Osman 
Published: June 2024

Context Carbon tetrachloride (CCl4) is a chemical that is still widely used in industry and has been shown to cause structural defects in rat testicles through oxidative stress. Aims In our study, the effect of curcumin on CCl4-mediated testicular damage was investigated. Methods Twenty-four adult Wistar albino male rats weighing 300–350 g were divided into four groups: control group (olive oil was applied by gavage every consecutive day for 3 weeks); curcumin and CCl4 + curcumin groups (200 mg/kg curcumin dissolved in olive oil was given by gavage once a day, every consecutive day for 3 weeks); and CCl4 and CCl4 + curcumin groups (0.5 mL/kg CCl4 was dissolved in olive oil at a ratio of 1/1 and given by i.p. injection every other day for 3 weeks). Tissue samples were examined histopathologically, histomorphometrically, immunohistochemically and biochemically. Key results CCl4 disrupted both testicular morphology and testosterone synthesis, whereas curcumin treatment resulted in an improvement in testicular morphology and biochemical parameters, as well as a decrease in caspase-3 and tumour necrosis factor-α expression. Conclusions Curcumin has a protective effect on testicular tissue damage caused by CCl4 with its anti-inflammatory, antiapoptotic and antioxantioxidant properties. Implications Curcumin can prevent testicular damage due to CCl4, an environmental pollutant.
A hybrid information fusion method for SINS/GNSS integrated navigation system utilizing GRU-aided AKF during GNSS outages
Authors: Xu Chuan , Chen Shuai , Hou Zhikuan 
Published: June 2024

Abstract
To enhance the performance of integrated inertial navigation system (INS) and global navigation satellite system (GNSS) during GNSS outages, this paper proposed a fusion positioning method based on predictive observation information and adaptive filter parameter. Combined with an adaptive Kalman filter (AKF) and a Gated Recurrent Unit neural network (NN) that directly relates the inertial measurement unit (IMU) output sequence to the error estimation, the hybrid information fusion system can provide effective corrections to compensate for horizontal position errors under the constraints of complex and dynamic vehicle movement data during GNSS outages. Meanwhile, the designed adaptive parameter of the integrated navigation filter can adjust the credibility of the state prediction section when the GNSS is reconnected, ensuring the system can switch rapidly between the INS/GNSS and INS/NN integrated modes. The performance of the proposed information fusion method has been experimentally validated using IMU and GNSS data collected in a vehicle navigation test conducted on a stretch of expressway. The comparison results indicate that the proposed algorithm has error suppression capabilities under various experimental constraints and demonstrates a degree of extendibility and reusability.
The first investigation of the dosimetric perturbations from the spot position errors in spot-scanning arc therapy (SPArc)
Authors: Liu Peilin , Zhao Lewei , Liu Gang , Cong Xiaoda , Li Xiaoqiang , Ding Xuanfeng 
Published: June 2024

Abstract

Objective. To quantitatively investigate the impact of spot position error (PE) on the dose distribution in (Spot-scanning arc therapy) SPArc plans compared to Intensity-Modulated Proton Therapy (IMPT). Approach. Twelve representative cases, including brain, lung, liver, and prostate cancers, were retrospectively selected. Spot PEs were simulated during dynamic SPArc treatment delivery. Two types of errors were generated, including random error and systematic error. Two different probability distributions of random errors were used (1) Gaussian distribution (PEran-GS) (2) uniform distribution (PEran-UN). In PEran-UN, four sub-scenarios were considered: 25%, 50%, 75%, and 100% spots were randomly selected in various directions on the scale of 0–1 mm or 0–2 mm of PE. Additionally, systematic error was simulated by shifting all the spot uniformly by 1 or 2 mm in various directions (PEsys). Gamma-index Passing Rate (GPR) is applied to assess the dosimetric perturbation quantitatively. Main results. For PEran-GS in the 1 mm scenario, both SPArc and IMPT are comparable with a GPR exceeding 99%. However, for PEran-GS in 2 mm scenario, SPArc could provide better GPR. As PEsys of 2 mm, SPArc plans have a much better GPR compared to IMPT plans: SPArc’s GPR is 99.59 ± 0.47%, 93.82 ± 4.07% and 64.58 ± 15.83% for 3 mm/3%, 2 mm/2% and 1 mm/1% criteria compared to IMPT with 97.49 ± 2.44%, 84.59 ± 4.99% and 42.02 ± 6.31%. Significance. Compared to IMPT, SPArc shows better dosimetric robustness in spot PEs. This study presents the first simulation results and the methodology that serves as a reference to guide future investigations into the accuracy and quality assurance of SPArc treatment delivery.
Spatial modulation instability and filamentation of Gaussian beam in metamaterials
Authors: Hashim N K , Shafeeque Ali A K , Gopi S , Asma Mir , Ullah Malik Zaka , Ahmad Fayyaz 
Published: June 2024

Abstract
This paper deals with a study on spatial modulation instability and propagation dynamics of a Gaussian beam in cubic and quintic nonlinear metamaterials. We explore the parametric regions where the laser beam can exhibit stable and unstable dynamics in terms of modulation instability of continuous waves. As the modulation instability is the precursor to forming an ultrashort pulse, here we generate trains of ultrashort pulses by the filamentation of the Gaussian beam. Also, we observe the modulational stability of continuous waves as well as the stable dynamics of Gaussian beam in metamaterials with competing cubic and quintic nonlinearities.
Dynamics of vortex and anti-vortex solitons in a vectorial cubic-quintic complex Ginzburg-Landau equation
Authors: Nko’o Nko’o Marius Jeannot , Djazet Alain , Mandeng Lucien Mandeng , Fewo Serge Ibraid , Tchawoua Clément , Kofané Timoléon Crépin , Tatchim Bemmo David 
Published: June 2024

Abstract
In this paper, we present a study of vortex and anti-vortex dynamics within a complex cubic-quintic Ginzburg-Landau vector equation (CCQGLVE). We employ a variational approach to address the analytical aspects, and the results obtained are subsequently confirmed numerically. The vortex vector (VV) and the anti-vortex vector (anti-VV) are defined with topological charges: m = 1 for VV and m = − 1 for anti-VV. Our investigation reveals that the stability zone map corresponds to the region where greater stability can be achieved for the two studied solutions. Notably, the radius of the vortex craters experiences variations either an increase or decrease depending on the competition between the coupling parameters associated with cubic and quintic cross-phase modulation (XPM). During the propagation, the interaction between a fundamental soliton and anti-VV transforms the soliton into a vortex after a short time, but both finally undergo self-confinement which probably will generates solitons. In the case of the interaction between a VV and a fundamental soliton, we observed a self-confinement and a transformation into solitons. Considering the interaction between a VV and an anti-VV, we found that both solutions are also self-confined but the anti-VV solution turns into a soliton faster than the VV solution. This confirms that the anti-VV is the better solution that can be managed with system coupling parameters than the VV one.
Phylogenetic differences in the morphology and shape of the central sulcus in great apes and humans: implications for the evolution of motor functions
Authors: Foubet Ophelie , Mangin Jean-François , Sun Zhong Yi , Sherwood Chet C , Hopkins William D 
Published: June 2024

Abstract
The central sulcus divides the primary motor and somatosensory cortices in many anthropoid primate brains. Differences exist in the surface area and depth of the central sulcus along the dorso-ventral plane in great apes and humans compared to other primate species. Within hominid species, there are variations in the depth and aspect of their hand motor area, or knob, within the precentral gyrus. In this study, we used post-image analyses on magnetic resonance images to characterize the central sulcus shape of humans, chimpanzees (Pan troglodytes), gorillas (Gorilla gorilla), and orangutans (Pongo pygmaeus and Pongo abelii). Using these data, we examined the morphological variability of central sulcus in hominids, focusing on the hand region, a significant change in human evolution. We show that the central sulcus shape differs between great ape species, but all show similar variations in the location of their hand knob. However, the prevalence of the knob location along the dorso-ventral plane and lateralization differs between species and the presence of a second ventral motor knob seems to be unique to humans. Humans and orangutans exhibit the most similar and complex central sulcus shapes. However, their similarities may reflect divergent evolutionary processes related to selection for different positional and habitual locomotor functions.