bluuebunny/crossref_metadata_2025_split huggingface dataset:
Thigmotaxis maintains processions of late‐instar caterpillars of Ochrogaster lunifer
Authors: STEINBAUER MARTIN J. 
Published: November 2009

Abstract.Processionary behaviour is a distinctive feature of the dispersal of caterpillars of a number of Lepidoptera, including Ochrogaster lunifer Herrich‐Schäffer (Lepidoptera: Notodontidae) from Australia. By cutting hairs on either the first or last three segments of the bodies of caterpillars and re‐introducing them into processions of normal caterpillars, the present study provides strong evidence that thigmotaxis is the mechanism that maintains single‐file, head‐to‐tail movement of groups of individuals. The inclusion of caterpillars whose posterior hairs have been cut results in the breakage of processions, whereas the inclusion of caterpillars whose anterior hairs have been cut rarely results in the breakage of processions. The breakage of processions occurs because caterpillars whose posterior hairs had been cut are difficult to follow and they will not stop when those behind became detached. The speed of movement of processions incorporating caterpillars whose hairs on the posterior segments of their bodies have been cut also has a significant effect on the likelihood of maintaining processionary movement; faster‐moving processions are more likely to break than are more slowly‐moving processions.
The relationship between pre‐oviposition flight behaviour and reproductive timing in whitefly parasitoids
Authors: ASPLEN MARK K. , HARDIN JESSE A. , BYRNE DAVID N. 
Published: November 2009

Abstract.Although the timing of oögenesis appears to be a major life‐history organizer in the parasitoid Hymenoptera, relatively little is known about how this trait correlates with population dispersal by flight in these wasps. Pre‐oviposition flight behaviours of 1‐day‐old female wasps in a vertical flight chamber are measured to test correlations between these traits and with reproductive timing. The focus of the present study is on two genera of whitefly parasitoids (Encarsia and Eretmocerus) that differ in reproductive timing when feeding on a shared host (Bemisia tabaci). The two Eretmocerus species engage in vertical flight within 3 min of release far more frequently than the three Encarsia species. Because the former typically possess a more time‐limited reproductive strategy than the latter, this lends support for a positive interspecific association between early‐life reproduction and early‐life flight incidence. Within species, however, egg load does not correlate with flight propensity for any of the tested species. Furthermore, in Eretmocerus eremicus, the relationship between effective flight distance (i.e. the product of vertical climb rate and flight duration) and egg load appears to be labile rather than fixed because different trials show evidence for either negative or positive correlations between these variables. The source of this context dependence may be variation in either biotic (e.g. longevity) or abiotic (e.g. temperature and relative humidity) factors.
Circadian rhythms and the evolution of photoperiodic timing in insects
Authors: SAUNDERS DAVID S. 
Published: November 2009

Abstract.This review discusses possible evolutionary trends in insect photoperiodism, mainly from a chronobiological perspective. A crucial step was the forging of a link between the hormones regulating diapause and the systems of biological rhythms, circadian or circannual, which have independently evolved in eukaryotes to synchronize physiology and behaviour to the daily cycles of light and darkness. In many of these responses a central feature is that the circadian system resets to a constant phase at the beginning of the subjective night, and then ‘measures’ the duration of the next scotophase. In ‘external coincidence’, one version of such a clock, light now has a dual role. First, it serves to entrain the circadian system to the stream of pulses making up the light/dark cycle and, second, it regulates the nondiapause/diapause switch in development by illuminating/not illuminating a specific light sensitive phase falling at the end of the critical night length. Important work by A. D. Lees on the aphid Megoura viciae using so‐called ‘night interruption experiments' demonstrates that pulses falling early in the night lead to long‐day effects that are reversible by a subsequent dark period longer than the critical night length and also show maximal sensitivity in the blue–green range of the spectrum. Pulses falling in the latter half of the night, however, produce long‐day effects that are irreversible by a subsequent long‐night and show a spectral sensitivity extending into the red. With movement to higher latitudes, insects develop genetic clines in various parameters, including critical night length, the number of long‐night cycles needed for diapause induction, the strength of the response, and the ‘depth’ or intensity of the diapause thus induced. Evidence for these and other types of photoperiodic response suggests that they provided strong selective advantages for insect survival.
Can herbivore‐induced plant volatiles inform predatory insect about the most suitable stage of its prey?
Authors: YONEYA KINUYO , KUGIMIYA SOICHI , TAKABAYASHI JUNJI 
Published: November 2009

Abstract.The leaf beetle Plagiodera versicolora (Coleoptera: Chrysomelidae) is a specialist herbivore, all of whose mobile stages feed on the leaves of salicaceous plants. Both the larval and adult stages of the ladybird Aiolocaria hexaspilota (Coleoptera: Coccinellidae) are dominant natural enemies of the larvae of the leaf beetle. To clarify the role of plant volatiles in prey‐finding behaviour of A. hexaspilota, the olfactory responses of the ladybird in a Y‐tube olfactometer are studied. The ladybird adults show no preference for willow plants Salix eriocarpa that are infested by leaf beetle adults (nonprey) over that for intact plants but move more to the willow plants infested by leaf beetle larvae (prey) than to intact plants. Moreover, ladybird larvae show no preference for willow plants infested by leaf beetle larvae or adults over intact plants. Using gas chromatography‐mass spectrometry, six volatile compounds are released in larger amounts in the headspace of willow plants infested by leaf beetle larvae than in the headspace of willow plants infested by leaf beetle adults. In addition, the total amount of volatiles emitted from willow plants that are either intact or infested by leaf beetle adults is much smaller than that from willow plants infested by leaf beetle larvae. These results indicate that volatiles from S. eriocarpa infested by P. versicolora inform A. hexaspilota adults about the presence of the most suitable stage of their prey, whereas A. hexaspilota larvae do not use such information.
The mitochondrial PPR protein LOVASTATIN INSENSITIVE 1 plays regulatory roles in cytosolic and plastidial isoprenoid biosynthesis through RNA editing
Authors: Tang Jianwei , Kobayashi Keiko , Suzuki Masashi , Matsumoto Shogo , Muranaka Toshiya 
Published: November 2009

SummaryUnlike animals, plants synthesize isoprenoids via two pathways, the cytosolic mevalonate (MVA) pathway and the plastidial 2‐C‐methyl‐d‐erythritol‐4‐phosphate (MEP) pathway. Little information is known about the mechanisms that regulate these complex biosynthetic networks over multiple organelles. To understand such regulatory mechanisms of the biosynthesis of isoprenoids in plants, we previously characterized the Arabidopsis mutant, lovastatin insensitive 1 (loi1), which is resistant to lovastatin and clomazone, specific inhibitors of the MVA and MEP pathways, respectively. LOI1 encodes a pentatricopeptide repeat (PPR) protein localized in mitochondria that is thought to have RNA binding ability and function in post‐transcriptional regulation of mitochondrial gene expression. LOI1 belongs to the DYW subclass of PPR proteins, which is hypothesized to be correlated with RNA editing. As a result of analysis of RNA editing of mitochondrial genes in loi1, a defect in RNA editing of three genes, nad4, ccb203 and cox3, was identified in loi1. These genes are related to the respiratory chain. Wild type (WT) treated with some respiration inhibitors mimicked the loi1 phenotype. Interestingly, HMG‐CoA reductase activity of WT treated with lovastatin combined with antimycin A, an inhibitor of complex III in the respiratory chain, was higher than that of WT treated with only lovastatin, despite the lack of alteration of transcript or protein levels of HMGR. These results suggest that HMGR enzyme activity is regulated through the respiratory cytochrome pathway. Although various mechanisms exist for isoprenoid biosynthesis, our studies demonstrate the novel possibility that mitochondrial respiration plays potentially regulatory roles in isoprenoid biosynthesis.
Lower risk of urinary tract infection with low‐dose trimethoprim/sulfamethoxazole compared to dapsone prophylaxis in older renal transplant patients on a rapid steroid‐withdrawal immunosuppression regimen
Authors: Giullian Jeffrey Allen , Cavanaugh Kerri , Schaefer Heidi 
Published: November 2009

Giullian JA, Cavanaugh K, Schaefer H. Lower risk of urinary tract infection with low‐dose trimethoprim/sulfamethoxazole compared to dapsone prophylaxis in older renal transplant patients on a rapid steroid‐withdrawal immunosuppression regimen. Clin Transplant 2009 DOI: 10.1111/j.1399‐0012.2009.01129.x © 2009 John Wiley & Sons A/S.Abstract:  Background:  Urinary tract infections (UTI) are common in renal transplant recipients. Trimethoprim/sulfamethoxazole (TMP/SMZ) in moderate to high daily doses prevents Pneumocystis jiroveci (PCP) and reduces the risk of UTI in renal transplant patients. Low‐dose TMP/SMZ also reduces the risk of PCP, although its ability to reduce the risk of UTI is uncertain.Design:  Retrospective review of 158 patients who received a renal transplant without corticosteroids for maintenance immunosuppression.Results:  Forty percent of patients initially prescribed TMP/SMZ ultimately stopped this medication early because of an adverse reaction. Urinary infection occurred in 16% without a significant difference in the risk of UTI between those treated with dapsone vs. those treated with TMP/SMZ (HR [95%CI]: 1.7 [0.75, 3.9], p = 0.2). In the subset of patients who were older than age 47 yr (mean age for this cohort, SD ± 6.2 yr), those treated with dapsone originally or who switched from TMP/SMZ to dapsone had a greater risk of UTI compared to patients who remained on TMP/SMZ (HR [95%CI]: 4.3 [1.2, 15.5], p = 0.024).Conclusions:  For renal transplant recipients over the age of 47 yr, treated without long‐term glucocorticoids, our retrospective data suggest that low‐dose TMP/SMZ is associated with a lower risk of UTI compared to dapsone prophylaxis.
Decreasing plasma soluble IL‐1 receptor antagonist and increasing monocyte activation early post‐transplant may be involved in pathogenesis of delayed graft function in renal transplant recipients
Authors: Sadeghi Mahmoud , Daniel Volker , Naujokat Cord , Schmidt Jan , Mehrabi Arianeb , Zeier Martin , Opelz Gerhard 
Published: November 2009

Sadeghi M, Daniel V, Naujokat C, Schmidt J, Mehrabi A, Zeier M, Opelz G. Decreasing plasma soluble IL‐1 receptor antagonist and increasing monocyte activation early post‐transplant may be involved in pathogenesis of delayed graft function in renal transplant recipients Clin Transplant 2010: 24: 415–423. © 2009 John Wiley & Sons A/S.Abstract:  Delayed graft function (DGF) increases the risk of acute allograft rejection and may affect long‐term graft survival. We compared pre‐transplant, early post‐transplant, and late post‐transplant serum creatinine (Cr) and plasma levels of neopterin, cytokines, and cytokine receptors/antagonists in patients with DGF (n = 39), slow graft function (SGF) (n = 43), or immediate graft function (IGF) (n = 30). Three and eight days post‐transplant, plasma neopterin (p < 0.001; p < 0.001), Soluble Interleukin‐6 (IL‐6) receptor (R) (p = 0.002; p = 0.001), and IL‐10 (p = 0.003; p = 0.001) were higher in DGF than IGF patients. One month post‐transplant, plasma neopterin (p < 0.001) and IL‐10 (p < 0.001) were higher in DGF than IGF patients. Three days post‐transplant, the results indicated reduced sIL‐1 receptor antognist (RA) production in DGF patients (p = 0.001). Simultaneously, plasma sIL‐6R and IL‐10 increased in DGF (p < 0.001; p = 0.003) and SGF (p = 0.007; p = 0.030) patients, indicating increased production of sIL‐6R and IL‐10. Lower sIL‐1 production in DGF than IGF patients early post‐transplant might promote the increased production of monocyte‐derived neopterin, sIL‐6R, and IL‐10. This monocyte/macrophage activation might induce inflammation in the graft and subsequently cause an impairment of graft function. Blocking of monocyte activity after renal transplantation may be considered a potential approach for improving graft outcome.
Comparison of urological complications with primary ureteroureterostomy versus conventional ureteroneocystostomy
Authors: Nie Zhilin , Zhang Keqin , Huo Wenqian , Li Qiansheng , Zhu Fangqiang , Jin Fengshuo 
Published: November 2009

Nie Z, Zhang K, Huo W, Li Q, Zhu F, Jin F. Comparison of urological complications with primary ureteroureterostomy versus conventional ureteroneocystostomy. Clin Transplant 2009 DOI: 10.1111/j.1399‐0012.2009.01134.x © 2009 John Wiley & Sons A/S.Abstract:  Urological complications after kidney transplantation may be serious and carry a high risk of graft loss. The purpose of this study was to compare urological complications with primary ureteroureterostomy versus conventional ureteroneocystostomy retrospectively. Between December 1993 and April 2008, 1287 kidney transplants were performed at our institution. Urological complications such as urine leakage, ureteral obstruction and vesicoureteral reflux (VUR) were summarized according to the different ways of urinary tract reconstruction, ureteroureterostomy (U‐U) and ureteroneocystostomy (U‐C). Overall, urological complications were encountered in 94 (7.3%) cases, including urine leakage (n = 44, 3.4%), ureteral obstruction (n = 36, 2.8%), VUR (n = 14, 1.1%). Seventy‐six cases (7.8%) were in the U‐C group and 18 cases (5.8%) were in the U‐U group. Ninety‐three recipients were successfully treated, and one lost the graft because of pelvis and ureteral necrosis. There was no recipient loss secondary to these complications. In conclusion, U‐U does not change the overall incidence of urological complications comparing to U‐C, but it can decrease the incidence of urine leakage. It is a good first option with a greater possibility of resolving a ureteral stenosis with endourology and no risk of reflux.
Hepatic and cardiac iron overload among patients with end‐stage liver disease referred for liver transplantation
Authors: O’Glasser Avital Y. , Scott David L. , Corless Christopher L. , Zaman Atif , Sasaki Anna , Gopal Deepak V. , Rayhill Stephen C. , Orloff Susan L. , Ham John M. , Rabkin John M. , Flora Ken , Davies Crispin H. , Broberg Craig S. , Schwartz Jonathan M. 
Published: November 2009

O’Glasser AY, Scott DL, Corless CL, Zaman A, Sasaki A, Gopal DV, Rayhill SC, Orloff SL, Ham JM, Rabkin JM, Flora K, Davies CH, Broberg CS, Schwartz JM. Hepatic and cardiac iron overload among patients with end‐stage liver disease referred for liver transplantation. Clin Transplant 2009 DOI: 10.1111/j.1399‐0012.2009.01136.x. © 2009 John Wiley & Sons A/S.Abstract: Background:  Iron overload is associated with fatal cardiovascular events following liver transplantation. Myocardial iron deposits were observed post‐mortem in patients who died of cardiac events after transplantation at our institution. This observation prompted testing to exclude cardiac iron in subsequent transplant candidates.Aims:  To assess the results of testing for iron overload in liver transplant candidates at our institution.Methods:  Ferritin, TIBC, and serum iron were measured in cirrhotics referred for transplantation. Patients with transferrin saturation ≥50% and ferritin ≥250 ng/mL underwent liver biopsy graded for iron. Patients with 3–4+ hepatic iron deposits underwent HFE mutation analysis and endomyocardial biopsy with iron staining.Results:  Eight hundred and fifty‐six patients were evaluated for liver transplantation between January 1997 and March 2005. Two hundred and eighty‐seven patients (34%) had transferrin saturation ≥50% and ferritin ≥250 ng/mL. Patients with markers of iron overload had more advanced liver disease than those with normal iron indices. One hundred and fifty‐three patients underwent liver biopsy. Twenty‐six patients (17%) had 3–4+ hepatic iron staining. One patient was a C282Y heterozygote. Endomyocardial biopsy was performed in 14 patients of whom nine had cardiac iron deposition.Conclusions:  Non‐HFE‐related cardiac iron overload can occur in advanced liver disease We therefore recommend screening for cardiac iron prior to liver transplantation.
Prospective study of polyomavirus BK replication and nephropathy in renal transplant recipients in China: a single‐center analysis of incidence, reduction in immunosuppression and clinical course
Authors: Huang Gang , Chen Li‐Zhong , Qiu Jiang , Wang Chang‐Xi , Fei Ji‐Guang , Deng Su‐Xiong , Li Jun , Chen Guo‐Dong , Zhang Lei , Fu Qian , Zeng Wen‐Tao , Zhao Da‐Qiang 
Published: November 2009

Huang G, Chen L‐Z, Qiu J, Wang C‐X, Fei J‐G, Deng S‐X, Li J, Chen G‐D, Zhang L, Fu Q, Zeng W‐T, Zhao D‐Q. Prospective study of polyomavirus BK replication and nephropathy in renal transplant recipients in China: a single‐center analysis of incidence, reduction in immunosuppression and clinical course. Clin Transplant 2009 DOI: 10.1111/j.1399‐0012.2009.01141.x © 2009 John Wiley & Sons A/S.Abstract:  Background:  BK virus (BKV)‐associated nephropathy (BKVAN) in renal transplant recipients is an important cause of renal transplant dysfunction. Our aim was to determine the kinetics of BKV load within one yr after kidney transplantation under the impact of intensive monitoring and reduction in maintenance immunosuppression, the incidence of BKVAN, and the outcome of BKVAN treatment.Methods:  Urine and peripheral blood (PB) were taken from 90 renal transplant recipients for BKV cytological testing and real‐time PCR for BKV DNA at one, three, six, nine, and 12 months after transplantation and treatment. Graft biopsies and urinary sediments of recipients with BKVAN were taken to monitor viral particles by conventional transmission electron microscopy (TEM).Results:  By one post‐transplant year, urinary decoy cells (median, 8/10 HPF), BKV viruria (median, 2.60 × 105 copies/mL), viremia (median, 9.65 × 103 copies/mL), and BKVAN occurred in 42.2%, 45.6%, 22.2%, and 5.6% of patients, respectively. The incidence of BK infection was lower in patients who received cyclosporine A (CsA) (28.9%) compared to tacrolimus (FK506) (57.7%) (p = 0.007). An increased hazard of BK infection was associated with the use of FK506 (HR 2.6, p = 0.009) relative to CsA. After reduction in immunosuppression, viremia resolved in 95%, without increased acute rejection, allograft dysfunction, or graft loss. BKVAN was diagnosed in five patients (5.6%). The treatment of immunosuppression reduction was effective (i.e., decreased the viral load and number of decoy cells, and improved graft function) in our five patients with BKVAN. Quantitative count of decoy cells (e.g., >10 per 10 HPF) as a marker of viremia and BKVAN had increased positive predictive values of 85.7% and 57.1%, respectively.Conclusions:  Choice of FK506 as immunosuppressive agent is an independent risk factor affecting BKV infection. Monitoring and pre‐emptive of immunosuppression reduction were associated with resolution of viremia and showed effective in BKVAN recipients at the early stage without acute rejection or graft loss. Quantitative count of urine cytology is a very convenient, useful, and sensitive method for evaluating BKV infection in renal transplant recipients.
Discrepancies between clinical and autopsy diagnoses in lung transplant recipients
Authors: Akindipe Olufemi A. , Fernandez‐Bussy Sebastian , Staples Edward D. , Baz Maher A. 
Published: November 2009

Akindipe OA, Fernandez‐Bussy S, Staples ED, Baz MA. Discrepancies between clinical and autopsy diagnoses in lung transplant recipients. Clin Transplant 2009 DOI: 10.1111/j.1399‐0012.2009.01144.x. © 2009 John Wiley & Sons A/S.Abstract:  We sought to investigate the role of autopsy diagnoses in lung transplantation by comparing the clinically derived cause of death with autopsy deduced cause of death in a cohort of lung transplant recipients. We retrospectively reviewed all consecutive autopsy findings on lung transplant recipients transplanted between March 1994 and March 2007. We reviewed medical records and our lung transplant database to determine the clinical diagnosis of cause of death based on the clinical assessment and discharge summary at the time of death. Our study showed that 21% of the autopsies performed on lung transplant recipients at our institution revealed findings unsuspected at the time of death. Myocardial infarction, pulmonary embolism, high grade acute cellular rejection and infections were the most frequently missed diagnoses. The autopsy remains a useful tool in confirming diagnostic accuracy in lung transplant recipients.
Chances and limitations of non‐invasive tests in the assessment of liver fibrosis in liver transplant patients
Authors: Kamphues Carsten , Lotz Katharina , Röcken Christoph , Berg Thomas , Eurich Dennis , Pratschke Johann , Neuhaus Peter , Neumann Ulf P. 
Published: November 2009

Kamphues C, Lotz K, Röcken C, Berg T, Eurich D, Pratschke J, Neuhaus P, Neumann UP. Chances and limitations of non‐invasive tests in the assessment of liver fibrosis in liver transplant patients. Clin Transplant 2009 DOI:10.1111/j.1399‐0012.2009.01152.x © 2009 John Wiley & Sons A/S.Abstract:  Because fibrosis progression resulting in liver cirrhosis represents the main reason for graft lost in patients after liver transplantation, an early detection of liver fibrosis is crucial. In recent years, several non‐invasive tests for the assessment of liver fibrosis have been developed. We prospectively assessed the stage of liver fibrosis of 135 liver transplant patients (94 hepatitis C virus [HCV], 41 alcoholic cirrhosis) using liver biopsy, transient elastography, and serum markers. In the HCV group, the area under the receiver operating characteristic curve (AUROC) for diagnosis of significant fibrosis (F ≥ 2) and cirrhosis (F = 4) was 0.81 (negative predictive value [NPV] = 0.58, positive predictive value [PPV] = 0.9) and 0.87 (NPV = 0.94, PPV = 0.56), respectively. In the alcoholic cirrhosis group, significant fibrosis (F ≥ 2) was diagnosed with an AUROC of 0.83 (NPV = 1.00, PPV = 0.23). In both groups, higher AUROC values were reached in patients with a body mass index of <25 kg/m2, and both serum markers showed no significant correlation to liver fibrosis. The transient elastography is a reliable test for exclusion of liver cirrhosis in HCV transplant and significant liver fibrosis in alcoholic transplant patients. For the diagnosis of significant liver fibrosis in HCV transplant patients, the transient elastography reaches good results but cannot replace liver biopsy. Both serum markers AST‐to‐platelet ratio index and FIB‐4 are not feasible to assess liver fibrosis in liver transplant patients.