bluuebunny/crossref_metadata_2025_split huggingface dataset:
Germline rare variants in HER2-positive breast cancer predisposition: a systematic review and meta-analysis
Authors: de Baumont Angelica Cerveira , Cadore Nathan Araujo , Pedrotti Luana Giongo , Curzel Giovana Dallaio , Schuch Jaqueline Bohrer , Bessel Marina , Bordignon Cláudia , Rosa Mahira Lopes , Macedo Gabriel de Souza , Rosa Daniela Dornelles 
Published: June 2024

IntroductionApproximately 10% of breast cancer (BC) cases result from hereditary causes. Genetic testing has been widely implemented in BC care to determine hereditary cancer syndromes and personalized medicine. Thus, identification of individuals carrying germline pathogenic variants could be useful to provide appropriate prophylactic or screening measures for each BC subtype, however, there are few formal recommendations for genetic testing in this sense so far. In this study, we assessed rare germline variants in a specific group of genes in order to determine the association with human epidermal growth factor 2 enriched (HER2+) BC phenotype through a systematic review and meta-analysis comparing subtypes overexpressing HER2 with other clinically recognized subtypes of BC. This review was registered with PROSPERO (ID: CRD42023447571).MethodsWe conducted an online literature search in PubMed (MEDLINE), Scopus, and EMBASE databases. We included original studies that investigated germline variants in HER2+ BC patients and selected the studies that reported only rare and/or pathogenic germline variants. We assessed the risk of bias and quality of the studies using the Joanna Briggs Institute Critical Appraisal checklists and the Modified Newcastle-Ottawa Scale for Genetic Studies, respectively. Considering hormone receptor and HER2 expression status, we compared gene-based risks initially in HR-HER2-, HR+HER2-, HR+HER2+, and HR-HER2+ groups, conducting separate meta-analyses using the random effects model for each comparison, and within them for each gene.ResultsOf the total 36 studies describing germline variants, 11 studies provided information on the prevalence of variants in the different clinically relevant BC subtypes and allowed comparisons. Germline variants within eight genes showed significant differences when meta-analyzed between the BC groups: BRCA1, BRCA2, TP53, ATM, CHEK2, PALB2, RAD51C, and BARD1. Notably, TP53, ATM, and CHEK2 germline variants were identified as predisposing factors for HER2+ subtypes, whereas BRCA1, BRCA2, PALB2, RAD51C, and BARD1 germline variants were associated with a predisposition to low HER2 expression. Main concerns about bias and quality assessment were the lack of confounding factors control; and comparability or outcome assessment, respectively. DiscussionOur findings underscore the connection between germline variants and differential expression of the HER2 protein and BC subtypes.Systematic review registrationhttps://www.crd.york.ac.uk/PROSPERO, identifier CRD42023447571.
Hungry pigeons prefer sooner rare food over later likely food or faster information
Authors: Wittek Neslihan , Sayin Berna Selin , Okur Nurdem , Wittek Kevin , Gül Naciye , Oeksuez Fatma , Güntürkün Onur , Anselme Patrick 
Published: June 2024

IntroductionMaking decisions and investing effort to obtain rewards may depend on various factors, such as the delay to reward, the probability of its occurrence, and the information that can be collected about it. As predicted by various theories, pigeons and other animals indeed mind these factors when deciding.MethodsWe now implemented a task in which pigeons were allowed to choose among three options and to peck at the chosen key to improve the conditions of reward delivery. Pecking more at a first color reduced the 12-s delay before food was delivered with a 33.3% chance, pecking more at a second color increased the initial 33.3% chance of food delivery but did not reduce the 12-s delay, and pecking more at a third color reduced the delay before information was provided whether the trial will be rewarded with a 33.3% chance after 12 s.ResultsPigeons’ preference (delay vs. probability, delay vs. information, and probability vs. information), as well as their pecking effort for the chosen option, were analyzed. Our results indicate that hungry pigeons preferred to peck for delay reduction but did not work more for that option than for probability increase, which was the most profitable alternative and did not induce more pecking effort. In this task, information was the least preferred and induced the lowest level of effort. Refed pigeons showed no preference for any option but did not drastically reduce the average amounts of effort invested.DiscussionThese results are discussed in the context of species-specific ecological conditions that could constrain current foraging theories.
A critical reflection on using the Patient Engagement In Research Scale (PEIRS) to evaluate patient and family partners' engagement in dementia research
Authors: Wong Joey , Hung Lillian , Bayabay Cates , Wong Karen Lok Yi , Berndt Annette , Mann Jim , Wong Lily , Jackson Lynn , Gregorio Mario 
Published: June 2024

IntroductionResearch involvement of people with lived experiences is increasing. Few tools are designed to evaluate their engagement in research. The Patient Engagement In Research Scale (PEIRS) is one of the few validated tools. Our team employed the PEIRS with patient and family partners with lived experiences of dementia every 6 months in a two-year telepresence robot project. This reflection paper reports our self-study on key learnings and proposes practical tips on using the PEIRS to evaluate patient and family partners' engagement in dementia research. It is the first to document a case using the PEIRS multiple times in a dementia research project.MethodsGuided by Rolfe et al.'s reflective model, we conducted three team reflective sessions to examine the team's experiences using the PEIRS to improve and evaluate patient and family partners' engagement in the research. We also reviewed our meeting notes and fieldnotes documented in the research journal. A reflexive thematic analysis was performed.ResultsThe team identified three key learnings: the values of using the PEIRS survey, the adaptations, and the factors influencing its implementation as an evaluation tool. Using the PEIRS provided significant benefits to the project, although some patient and family partners felt it was burdensome. The evaluation tool was enhanced with emojis and comment boxes based on suggestions from patient partners. The emojis introduced an element of fun, while the comment boxes allowed for personalized responses. Several factors influenced the PEIRS tool's effectiveness: the interviewer's identity, the confidentiality of responses and follow-ups, the timing and frequency of using the tool, and the presentation of the evaluations. These learnings led to the development of six practical tips,—“ENGAGE”: Enjoyable and fun process, Never impose, Get prepared early, Adapt to the team's needs, Give people options, and Engage and reflect.ConclusionWith the emerging trend of including people with lived experiences in dementia research, there is a need for ongoing assessment of engagement from both patient and family partners and the research team strategies. Future research can further explore survey logistics, co-development of evaluation tools, and the use of tools with people living with dementia.
Quimioterapia metronómica en paciente hematológico como alternativa no curativa, en el Hospital Nacional de Niños “Dr. Carlos Sáenz Herrera” de enero 2016 a diciembre 2019.
Authors: Valverde Muñoz Kathia , Chacón Hernández Gabriela , Gutiérrez Valverde Daniela , Rodríguez Rodríguez Jorge , Granados Alfaro Paola 
Published: June 2024

La Quimioterapia Metronómica consiste en la administración de quimioterapia a dosis bajas y en intervalos, utilizada en casos de cáncer avanzado con mínimos efectos secundarios, para mantener la enfermedad estable y mejorar la calidad de vida, junto con soporte paliativo. Este es un estudio observacional retrospectivo, que abarca un período de 3 años, de enero de 2016 a diciembre de 2019, a partir del cual se caracterizan los pacientes con enfermedad hematológica que utilizan quimioterapia metronómica como opción no curativa del Hospital Nacional de Niños “Dr. Carlos Sáenz Herrera” de la Caja Costarricense del Seguro Social. De un total de 52 pacientes, el género que predominó fue el sexo masculino con un 75.0%. En la tasa de incidencia según provincia, Limón fue de mayor auge con 6.9 x 100 000 habitantes menores de 13 años, seguido de San José con 6.4 x 100 000 habitantes menores de 13 años y Guanacaste con 6.2 x 100 000 habitantes menores de 13 años. La sintomatología durante el tratamiento fue dolor articular en 35.2%, inapetencia 21.1%, cansancio 13%, y sangrado en 7.7%. El 92.3% de los pacientes fallecieron antes de los 3 años; 5.8% han tenido una enfermedad estable. El 72.3% de los pacientes fallecieron en la casa y solo un 27.6% en el hospital. Se concluye que el régimen de quimioterapia metronómica fue bien tolerado, con una tendencia positiva para los pacientes que han agotado las posibilidades terapéuticas vigentes; incluyendo un abordaje multidisciplinario con el equipo de cuidado paliativo.
Presentación Dossier: Perspectivas Pedagógicas Acerca de los problemas de la Educación
Authors: Garatte María Luciana , Todone Virginia , Marini Paula , Pellegrini Malpiedi Micaela 
Published: June 2024

El presente Dossier denominado “Perspectivas Pedagógicas acerca de los problemas de la Educación”, propone un espacio de intercambio y debate acerca del lugar que ha tenido históricamente la Pedagogía. Cuando nos referimos a ella, solemos entenderla en relación a las reflexiones que se generan alrededor de la educación. Es así, que preguntamos por el contenido de esas reflexiones, su naturaleza, los contenidos que trata la Pedagogía y su configuración histórica.
La reflexión pedagógica puede pensarse a partir de preguntas simples, situación que no quita que demanden un gran recorrido y un esfuerzo para llegar a algunas respuestas. En este sentido, el vocabulario que usamos para hablar de educación no es una mera cuestión de terminología. Sostenemos que vale la pena interrogarse por los objetos y reglas que definen y han definido históricamente sus límites y fronteras, los contenidos que incluye y los que excluye. Por otro lado, la situación que vivimos durante la pandemia puso sobre la mesa la necesidad de producción de conocimiento pedagógico, y del acompañamiento y la intervención de las y los educadores.
PENGEMBANGAN SISTEM PENJUALAN USAHA MIKRO KECIL MENENGAH (UMKM) BERBASIS WEB MENGGUNAKAN ODOO.
Authors: Ermi Ermi saraswati , Wimar ardana gulo  , Ryano marcel praditya  , Dimas muhammad ilham  , Agung Wibowo  
Published: June 2024

Umkm memiliki peranan yang sangat krusial dalam roda perekonomian nasional, umkm merupakan pilar utama dalam perekonomian nasional. Tercatat umkm memiliki kontribusi sebesar 61.07% terhadap produk domestik bruto. Namun terdapat permasalahan dimana persaingan yang semakin ketat menyebabkan sulit bersaing dalam hal promosi dengan produk-produk lainya. Penelitian ini berfokus pada pengembangan sebuah sistem berbasis web dengan menggunakan software open source odoo, tujuan dari pembuatan website adalah untuk merancang sistem informasi penjualan bunga plastik, perkembangan teknologi internet yang sekarang sudah berkembang dengan sangat cepat hal ini berdampak pada kemudahan dalam berbagai bidang pekerjaan, sehingga pengembang web akan lebih mudah dan cepat. Tahapan dalam pengembangan sistem website ini menggunakan metodology waterfall, dan langkah-langkah metodenya yaitu metode pengumpulan data yang diperoleh dengan mempelajari, meneliti dan membaca buku,jurnal,skripsi yang berhubungan dengan pengembangan sistem. Hasil pengujian dapat disimpulkan bahwa sistem informasi umkm berbasis web dapat membantu untuk mempromosikan pelaku umkm secara online yang dapat dengan mudah di akses oleh orang awam cukup dengan mengunjungi web. Dan analisi ini menunjukan bahwa studi yang berfokus pada pengembangan sebuah sistem berbasis web berkaitan dengan daya saing bisnis pasar.
Kata Kunci: Sistem Penjualan, UMKM, ODOO
ANALISI PERBANDINGAN PENDAPATAN SEMANGKA NON BIJI DAN SEMANGKA BIJI DI KELOMPOK TANI MILENIAL (POKTAN MILENIAL) DESA NOELBAKI KECAMATAN KUPANG TENGAH KABUPATEN KUPANG
Authors: Daka Ifoni Bulu , Olviana Tomycho , Elvani Siska 
Published: June 2024

This research aims to determine the analysis of non-seed watermelon and seeded watermelon in the Millennial Farmer Group (Poktan Millenial) in Noelbaki Village, Central Kupang District, Kupang Regency, followed by finding a comparison of the income of non-seed watermelon and seeded watermelon farmers. The location was determined deliberately based on certain considerations, because this location is one of the watermelon producing areas in the Millennial Farmers Group (Poktan Millennial). The method used in this research is quantitative descriptive using revenue analysis and income analysis. The results of this research show that the income from non-seed watermelon farming is greater when compared to seeded watermelon farming. Where non-seed watermelon farming income is more than IDR 40,968,613, while seed watermelon farming income is IDR 16,137,863. The comparison of income from non-seed watermelon farming and seed watermelon farming of Rp. 24,830,750 hah is proven that the results of the t-count test are known. The t-count value is 3.092> the t-table value is 2.073. Thus, there is a very significant difference between non-seed watermelon farming and seed watermelon farming. Comparative analysis of the income of non-seed watermelon and seeded watermelon in the Millennial Farmer Group (Poktan Millennial) has a significant effect on farmer income.
Health status of Hemodialysis Patients with End Stage Kidney Disease in Kirkuk City
Authors: Taha Mujda Najim , Kumait Abid Salih 
Published: June 2024

Background: Hemodialysis is a treatment for end-stage renal disease (ESRD) in which a machine filters waste and excess fluids from the blood for patients whose kidneys can no longer perform this function on their own. The health status of a hemodialysis patient can vary depending on several factors, including the underlying cause of their kidney disease, their overall health and medical history, the effectiveness of their dialysis treatments, and their adherence to their treatment plan.
Aim: This study aimed to assess health status of hemodialysis patients with end stage kidney disease in Kirkuk city: 2023-2024.
Methods: Cross –sectional study design conducted from 10 February 2023 to 22 May 2024.This study was conducted at Kirkuk City Hospitals . A purposive sample (non-probability) consisting of 100 patients under hemodialysis at Kirkuk city hospitals . . Data were collected using an interview-structured questionnaire. The structured questionnaire consisted of three main domain includes demographic data, medical data and health status domain which includes (independency, daily physical activity, psychosocial, and life adaptation. A three-point Likert scale was employed, with (3) representing always, (2) some times and (1) for never. Mean of score categorized as low significant less than 1.8, moderate significant :1.8 to 2.39 and high significant between 2.4 to 3. The data were prepared, organized and entered into the computer file; Statistical Package for Social Science (SPSS) (23 version .The significance level for statistical analysis was set at p<0.05.. The descriptive data analysis (frequencies, percentages) and inferential statics by use Anova and T, test was used for categorical variables
Results: The results shows the male more than female and constitute 60 (60.0%), most of "Age Groups", between (50-59) years and constitute 35.0% in the dialysis patients
Conclusions: health status of patients with hemodialysis patients different according to independency, daily physical activities, psycho- social aspects, and adaptation of life., mean score for hemodialysis patients were high and moderate in most items, Health status of hemodialysis patients were poor, Socio-demographic characteristics of hemodialysis patients age, gender, marital status and occupation has significant effect on health status at p<0.05.
Naming in a multilingual context: Norms for the ICMR-Manipal colour picture corpus in Kannada from the Indian context
Authors: Shenoy Rajath , Nickels Lyndsey , Krishnan Gopee 
Published: June 2024

AbstractThere have been many published picture corpora. However, more than half of the world’s population speaks more than one language and, as language and culture are intertwined, some of the items from a picture corpus designed for a given language in a particular culture may not fit another culture (with the same or different language). There is also an awareness that language research can gain from the study of bi-/multilingual individuals who are immersed in multilingual contexts that foster inter-language interactions. Consequently, we developed a relatively large corpus of pictures (663 nouns, 96 verbs) and collected normative data from multilingual speakers of Kannada (a southern Indian language) on two picture-related measures (name agreement, image agreement) and three word-related measures (familiarity, subjective frequency, age of acquisition), and report objective visual complexity and syllable count of the words. Naming labels were classified into words from the target language (i.e., Kannada), cognates (borrowed from/shared with another language), translation equivalents, and elaborations. The picture corpus had > 85% mean concept agreement with multiple acceptable names (1–7 naming labels) for each concept. The mean percentage name agreement for the modal name was > 70%, with H-statistics of 0.89 for nouns and 0.52 for verbs. We also analyse the variability of responses highlighting the influence of bi-/multilingualism on (picture) naming. The picture corpus is freely accessible to researchers and clinicians. It may be used for future standardization with other languages of similar cultural contexts, and relevant items can be used in languages from different cultures, following suitable standardization.
SEMA3: A free smartphone platform for daily life surveys
Authors: O’Brien Sarah T. , Dozo Nerisa , Hinton Jordan D. X. , Moeck Ella K. , Susanto Rio , Jayaputera Glenn T. , Sinnott Richard O. , Vu Duy , Alvarez-Jimenez Mario , Gleeson John , Koval Peter 
Published: June 2024

AbstractTraditionally, behavioral, social, and health science researchers have relied on global/retrospective survey methods administered cross-sectionally (i.e., on a single occasion) or longitudinally (i.e., on several occasions separated by weeks, months, or years). More recently, social and health scientists have added daily life survey methods (also known as intensive longitudinal methods or ambulatory assessment) to their toolkit. These methods (e.g., daily diaries, experience sampling, ecological momentary assessment) involve dense repeated assessments in everyday settings. To facilitate research using daily life survey methods, we present SEMA3 (http://www.SEMA3.com), a platform for designing and administering intensive longitudinal daily life surveys via Android and iOS smartphones. SEMA3 fills an important gap by providing researchers with a free, intuitive, and flexible platform with basic and advanced functionality. In this article, we describe SEMA3’s development history and system architecture, provide an overview of how to design a study using SEMA3 and outline its key features, and discuss the platform’s limitations and propose directions for future development of SEMA3.
Les solidarités afro-asiatiques des écrivains communistes turcs
Authors: Cadeau Noémie 
Published: June 2024

Si le parcours internationaliste du poète Nâzım Hikmet est bien connu, sa figure a éclipsé ses successeurs de l’historiographie des lettres turques. Or, depuis la fondation de l’Association des écrivains afro-asiatiques en 1958 à Tachkent, les écrivains communistes turcs ont pris part à ces réseaux tiers-mondistes placés sous l’égide soviétique. Les écrivains turcs avaient un statut ambivalent dans les associations afro-asiatiques, la Turquie n’étant ni un ancien pays colonisé, ni un État socialiste. Les communistes turcs étaient donc marginaux au sein de ces réseaux de solidarité anticolonialistes : à la fois orientaux et occidentaux, à la fois temporairement colonisés et tributaires d’un passé impérial, c’est davantage leur statut de communistes exilés et opprimés qui leur a permis de s’intégrer dans les organisations afro-asiatiques. Les correspondances, témoignages et archives du satiriste Aziz Nesin et du poète Ataol Behramoğlu sont mis en regard afin d’explorer cette hypothèse.
Commun de la liberté ou constitution du droit social ? Catherine Colliot-Thélène et la défense des droits subjectifs
Authors: Bourdeau Vincent 
Published: June 2024

Dans son dernier ouvrage, Le commun de la liberté (2022), Catherine Colliot-Thélène opère un retour à Kant qui lui paraît offrir une défense plus robuste des droits subjectifs et offrir, surtout, à ces droits toutes les garanties nécessaires à leur effectivité, notamment à partir d’une réflexion sur l’universalisation de la propriété privée comprise comme un droit fondamental. Cette voie – qui permet de renforcer la définition du sujet de droit comme sujet politique défendue dans La démocratie sans « demos » (2011) – rejoint celle de la réciprocité des pouvoirs, décrite – et écartée – dans le néo-républicanisme de Philip Pettit. Notre article cherchera à comprendre si un retour à Hegel, interprété à la lumière des analyses proposées par Colliot-Thélène dans un précédent ouvrage, Le désenchantement de l’État (1992), n’offre pas une meilleure stratégie pour la défense des droits subjectifs, en adossant ces derniers à l’antécédence d’un ordre social juste.
Des « vaincus » en prison : imaginaire et discours de collaborateurs épurés à la Libération
Authors: Limare Antoine 
Published: June 2024

L’histoire de l’épuration en France s’intéresse de plus en plus aux acteurs et à leur vécu au moment de la Libération. Pourtant, si les statistiques concernant la répression de la collaboration sont bien connues, il est peu fait cas de la manière dont les peines ont été appliquées, en particulier concernant l’enfermement des collaborateurs. L’étude de l’imaginaire des épurés permet d’envisager à la fois ce phénomène particulier de la « prison politique » tout en montrant en quoi l’épuration est un phénomène matriciel pour l’extrême droite française, dans la seconde moitié du XXe siècle.
Poursuivre la lutte contre le régime franquiste malgré l’enfermement : les combats des militants des Commissions ouvrières incarcérés à Carabanchel entre 1970 et 1975
Authors: Sudre Virginie Robleda 
Published: June 2024

Les conditions de détention des prisonniers politiques dans la prison de Carabanchel à Madrid révèlent les défis auxquels ils étaient confrontés et mettent en lumière leur résilience face à l’oppression. Malgré leur enfermement, les prisonniers politiques continuent à mener des combats qui prolongent efficacement le travail de sape entrepris par l’opposition en dehors des murs de la prison. Le constat des conditions d’incarcération des prisonniers politiques à Carabanchel dans les années 1970 nous permet de réaffirmer que la violence à l’encontre de ses opposants demeurait un élément central du régime dictatorial. Les prisonniers politiques ont su adapter leurs stratégies de lutte pendant leur détention. Les deux principaux axes de leur combat étaient la demande de reconnaissance du statut de prisonnier politique des militants enfermés par le régime, et la médiatisation des procès politiques montrant le vrai visage d’une dictature toujours bien présente mais se fissurant peu à peu. L’enfermement des opposants politiques se retournait ainsi contre la dictature : s’il contraignait les voix divergentes, il ne permettait pas de les réduire au silence, et leur lutte sans cesse renouvelée permettait de mettre un peu plus en lumière l’autoritarisme du régime.