bluuebunny/crossref_metadata_2025_split huggingface dataset:
Acute Ethanol Intoxication and the Trauma Patient: Hemodynamic Pitfalls
Authors: Bilello John , McCray Victor , Davis James , Jackson LaScienya , Danos Leigh Ann 
Published: July 2011

AbstractMany trauma patients are acutely intoxicated with alcohol. Animal studies have demonstrated that acute alcohol intoxication inhibits the normal release of epinephrine, norepinephrine, and vasopressin in response to acute hemorrhage. Ethanol also increases nitric oxide release and inhibits antidiuretic hormone secretion. This article studies the effects of alcohol intoxication (measured by blood alcohol level, BAL) on the presentation and resuscitation of trauma patients with blunt hepatic injuries. A retrospective registry and chart review was conducted of all patients who presented with blunt liver injuries at an ACS‐verified, level I trauma center. Data collected included admission BAL, systolic blood pressure, hematocrit, International Normalized Ratio (INR), liver injury grade, Injury Severity Score (ISS), intravenous fluid and blood product requirements, base deficit, and mortality. From September 2002 to May 2008, 723 patients were admitted with blunt hepatic injuries. Admission BAL was obtained in 569 patients, with 149 having levels >0.08%. Intoxicated patients were more likely to be hypotensive on admission (p = 0.01) despite a lower liver injury grade and no significant difference in ISS. There was no significant difference in the percent of intoxicated patients requiring blood transfusion. However, when blood was given, intoxicated patients required significantly more units of packed red blood cells (PRBC) than their nonintoxicated counterparts (p = 0.01). Intoxicated patients also required more intravenous fluid during their resuscitation (p = 0.002). Alcohol intoxication may impair the ability of blunt trauma patients to compensate for acute blood loss, making them more likely to be hypotensive on admission and increasing their PRBC and intravenous fluid requirements. All trauma patients should have BAL drawn upon admission and their resuscitation should be performed with an understanding of the physiologic alterations associated with acute alcohol intoxication.
Random UV-C mutagenesis ofScheffersomyces(formerlyPichia)stipitisNRRL Y-7124 to improve anaerobic growth on lignocellulosic sugars
Authors: Hughes Stephen R , Gibbons William R , Bang Sookie S , Pinkelman Rebecca , Bischoff Kenneth M , Slininger Patricia J , Qureshi Nasib , Kurtzman Cletus P , Liu Siqing , Saha Badal C , Jackson John S , Cotta Michael A , Rich Joseph O , Javers Jeremy E 
Published: July 2011

AbstractScheffersomyces (formerly Pichia) stipitis NRRL Y-7124 was mutagenized using UV-C irradiation to produce yeast strains for anaerobic conversion of lignocellulosic sugars to ethanol. UV-C irradiation potentially produces large numbers of random mutations broadly and uniformly over the whole genome to generate unique strains. Wild-type cultures of S. stipitis NRRL Y-7124 were subjected to UV-C (234 nm) irradiation targeted at approximately 40% cell survival. When surviving cells were selected in sufficient numbers via automated plating strategies and cultured anaerobically on xylose medium for 5 months at 28°C, five novel mutagenized S. stipitis strains were obtained. Variable number tandem repeat analysis revealed that mutations had occurred in the genome, which may have produced genes that allowed the anaerobic utilization of xylose. The mutagenized strains were capable of growing anaerobically on xylose/glucose substrate with higher ethanol production during 250- to 500-h growth than a Saccharomyces cerevisiae yeast strain that is the standard for industrial fuel ethanol production. The S. stipitis strains resulting from this intense multigene mutagenesis strategy have potential application in industrial fuel ethanol production from lignocellulosic hydrolysates.
Combined methylmalonic acidemia and homocystinuria, cblC type. II. Complications, pathophysiology, and outcomes
Authors: Carrillo‐Carrasco Nuria , Venditti Charles P. 
Published: July 2011

AbstractCombined methylmalonic acidemia and homocystinuria, cblC type, is stated to be the most common inborn error of intracellular cobalamin metabolism. The disorder can display a wide spectrum of clinical manifestations, spanning the prenatal period through late adulthood. While increased homocysteine concentrations and impaired methyl group metabolism may contribute to disease‐related complications, the characteristic macular and retinal degeneration seen in many affected patients appears to be unique to cblC disease. The early detection of cblC disease by newborn screening mandates a careful assessment of therapeutic approaches and provides a new opportunity to improve the outcome of affected patients. The following article reviews the current knowledge on the complications, pathophysiology, and outcome of cblC disease in an effort to better guide clinical practice and future therapeutic trials.
Natural history of alkaptonuria revisited: analyses based on scoring systems
Authors: Ranganath Lakshminarayan R. , Cox Trevor F. 
Published: July 2011

AbstractIncreased circulating homogentisic acid in body fluids occurs in alkaptonuria (AKU) due to lack of enzyme homogentisate dioxygenase leading in turn to conversion of HGA to a pigmented melanin‐like polymer, known as ochronosis. The tissue damage in AKU is due to ochronosis. A potential treatment, a drug called nitisinone, to decrease formation of HGA is available. However, deploying nitisinone effectively requires its administration at the most optimal time in the natural history. AKU has a long apparent latent period before overt ochronosis develops. The rate of change of ochronosis and its consequences over time following its recognition has not been fully described in any quantitative manner. Two potential tools are described that were used to quantitate disease burden in AKU. One tool describes scoring the clinical features that includes clinical assessments, investigations and questionnaires in 15 patients with AKU. The second tool describes a scoring system that only includes items obtained from questionnaires in 44 people with AKU. Analysis of the data reveals distinct phases of the disease, a pre‐ochronotic phase and an ochronotic phase. The ochronotic phase appears to demonstrate an earlier slower progression followed by a rapidly progressive phase. The rate of change of the disease will have implications for monitoring the course of the disease as well as decide on the most appropriate time that treatment should be started for it to be effective either in prevention or arrest of the disease.
Attitudes and Beliefs of African‐Americans Toward Genetics, Genetic Testing, and Sickle Cell Disease Education and Awareness
Authors: Long Katie A. , Thomas Stephen B. , Grubs Robin E. , Gettig Elizabeth A. , Krishnamurti Lakshmanan 
Published: July 2011

AbstractResearch among African‐Americans indicates this population perceives sickle cell (SCD) to be a serious disease and sickle cell trait (SCT) screening an important intervention. However, studies have consistently demonstrated a lower than desired uptake of SCD education, inadequate knowledge regarding personal and family trait status, and a low perceived susceptibility of giving birth to a child with the disease. We examined general attitudes and beliefs regarding genetics and genetic testing including prenatal testing and newborn screening; we used this information as the foundation to more specifically assess attitudes and beliefs regarding SCD and perceived barriers to SCD education and awareness. Thirty‐five African‐American adult men and women participated in one of four focus groups. Thematic analysis identified that both prenatal testing and newborn screening are acceptable forms of genetic testing. Based largely on their personal experiences, participants possessed an understanding of the natural progression of SCD but had a limited understanding of the inheritance and probable risk of giving birth to a child with the disease. Barriers to education and greater awareness of SCD were classified as personal, familial, and societal. Community based interventions focused on sharing the stories of individuals with first‐hand experiences with SCD should be considered.
Probabilistic Projections of the Total Fertility Rate for All Countries
Authors: Alkema Leontine , Raftery Adrian E. , Gerland Patrick , Clark Samuel J. , Pelletier François , Buettner Thomas , Heilig Gerhard K. 
Published: July 2011

AbstractWe describe a Bayesian projection model to produce country-specific projections of the total fertility rate (TFR) for all countries. The model decomposes the evolution of TFR into three phases: pre-transition high fertility, the fertility transition, and post-transition low fertility. The model for the fertility decline builds on the United Nations Population Division’s current deterministic projection methodology, which assumes that fertility will eventually fall below replacement level. It models the decline in TFR as the sum of two logistic functions that depend on the current TFR level, and a random term. A Bayesian hierarchical model is used to project future TFR based on both the country’s TFR history and the pattern of all countries. It is estimated from United Nations estimates of past TFR in all countries using a Markov chain Monte Carlo algorithm. The post-transition low fertility phase is modeled using an autoregressive model, in which long-term TFR projections converge toward and oscillate around replacement level. The method is evaluated using out-of-sample projections for the period since 1980 and the period since 1995, and is found to be well calibrated.
Acceptance and commitment therapy as guided self-help for psychological distress and positive mental health: a randomized controlled trial
Authors: Fledderus M. , Bohlmeijer E. T. , Pieterse M. E. , Schreurs K. M. G. 
Published: July 2011

BackgroundIn order to reduce the high prevalence of depression, early interventions for people at risk of depression are warranted. This study evaluated the effectiveness of an early guided self-help programme based on acceptance and commitment therapy (ACT) for reducing depressive symptomatology.MethodParticipants with mild to moderate depressive symptomatology were recruited from the general population and randomized to the self-help programme with extensive email support (n=125), the self-help programme with minimal email support (n=125) or to a waiting list control group (n=126). Participants completed measures before and after the intervention to assess depression, anxiety, fatigue, experiential avoidance, positive mental health and mindfulness. Participants in the experimental conditions also completed these measures at a 3-month follow-up.ResultsIn the experimental conditions significant reductions in depression, anxiety, fatigue, experiential avoidance and improvements in positive mental health and mindfulness were found, compared with the waiting list condition (effect sizes Cohen's d=0.51–1.00). These effects were sustained at the 3-month follow-up. There were no significant differences between the experimental conditions on the outcome measures.ConclusionsThe ACT-based self-help programme with minimal email support is effective for people with mild to moderate depressive symptomatology.
Amygdala to hippocampal volume ratio is associated with negative memory bias in healthy subjects
Authors: Gerritsen L. , Rijpkema M. , van Oostrom I. , Buitelaar J. , Franke B. , Fernández G. , Tendolkar I. 
Published: July 2011

BackgroundNegative memory bias is thought to be one of the main cognitive risk and maintenance factors for depression, but its neural substrates are largely unknown. Here, we studied whether memory bias is related to amygdala and hippocampal volume, two structures that are critical for emotional memory processes and that show consistent volume alterations in depression.MethodStructural magnetic resonance imaging (MRI) was carried out in 272 healthy participants (62% female, 18–50 years old). All images were acquired on 1.5 T Siemens MRI scanners. Automatic segmentation of amygdala and hippocampus was performed using the FIRST module of FSL. Negative memory bias was assessed by the self-referent encoding/evaluation test.ResultsNegative memory bias was associated with larger amygdala (p=0.042) and smaller hippocampal (p=0.029) volumes. In additional analyses, we found that, compared with the associations found with hippocampus and amygdala volume separately, a stronger association was found between negative memory bias and the ratio of amygdala:hippocampus volume (p=0.021).ConclusionsIn non-depressed subjects we found that larger amygdala and smaller hippocampal volumes are associated with negative memory bias. This suggests that an increased amygdala:hippocampus volume ratio plays a role in cognitive vulnerability often seen in individuals with high risk for depression and that these structural brain differences may pre-date the onset of depression.
Energy dissipation of ion beam in two-component plasma in the presence of laser irradiation
Authors: Hu Zhang-Hu , Song Yuan-Hong , Mišković Z.L. , Wang You-Nian 
Published: July 2011

AbstractWe use a two-dimensional particle-in-cell simulation to investigate the dynamic polarization and stopping power for an ion beam propagating through a two-component plasma, which is simultaneously irradiated by a strong laser pulse. Compared to the laser-free case, we observe a reduction in the instantaneous stopping power that initially follows the shape of the laser pulse and becomes particularly large as the laser frequency approaches the plasma electron frequency. We attribute this large reduction in the ion stopping power to an increase in plasma temperature due to the energy absorbed in the plasma from the laser pulse through the process of wave heating. In addition, dynamic polarization of the plasma by the ion is found to be strongly modulated by the laser field.
Nonlinear absorption of intense short pulse laser over a metal surface embedded with nanoparticles
Authors: Kumar Ashok , Verma A. L. 
Published: July 2011

AbstractThe anomalous absorption of laser, incident at an arbitrary angle of incidence on a metal surface embedded with nanoparticles, is studied. The electrons inside a nanoparticle resonantly absorb laser energy when the laser frequency equals the frequency of surface charge oscillations of the nanoparticle. A monolayer of nanoparticles of radius rnp0 ≈ 50 A with inter-particle separation d ~ 10rnp0 can cause up to 40% reduction of the reflection of p-polarized laser light. The absorption coefficient increases with the angle of incidence and has a sharp peak at a resonant frequency width of about 1%. At high laser power, even if the nanoparticles are initially off resonant with the laser, the particle heating and subsequent expansion reduces the resonance frequency, and the resonance absorption is realized after a time delay. The delay is found to be directly proportional to the cluster size and inversely proportional to the laser intensities.
An inverse optimization approach for determining weights of joint displacement objective function for upper body kinematic posture prediction
Authors: Zou Qiuling , Zhang Qinghong , Yang Jingzhou (James) , Gragg Jared 
Published: July 2011

SUMMARYHuman posture prediction can often be formulated as a nonlinear multiobjective optimization (MOO) problem. The joint displacement function is considered as a benchmark of human performance measures. When the joint displacement function is used as the objective function, posture prediction is a MOO problem. The weighted-sum method is commonly used to find a Pareto solution of this MOO problem. Within the joint displacement function, the relative value of the weights associated with each joint represents the relative importance of that joint. Usually, weights are determined by trial and error approaches. This paper presents a systematic approach via an inverse optimization approach to determine the weights for the joint displacement function in posture prediction. This inverse optimization problem can be formulated as a bi-level optimization problem. The design variables are joint angles and weights. The cost function is the summation of the differences between two set of joint angles (the design variables and the realistic posture). Constraints include (1) normalized weights within limits and (2) an inner optimization problem to solve for joint angles (predicted posture). Additional constraints such as weight limits and weight linear equality constraints, obtained through observations, are also implemented in the formulation to test the method. A 24 degree of freedom human upper body model is used to study the formulation and visualize the prediction. An in-house motion capture system is used to obtain the realistic posture. Four different percentiles of subjects are selected to run the experiment. The set of weights for the general seated posture prediction is obtained by averaging all weights for all subjects and all tasks. On the basis of obtained set of weights, the predicted postures match the experimental results well.
Toward safe and stable time-delayed mobile robot teleoperation through sampling-based path planning
Authors: Nieto Jorge , Slawiñski Emanuel , Mut Vicente , Wagner Bernardo 
Published: July 2011

SUMMARYThis work proposes a teleoperation architecture for mobile robots in partially unknown environments under the presence of variable time delay. The system is provided with artificial intelligence represented by a probabilistic path planner that, in combination with a prediction module, assists the operator while guaranteeing a collision-free motion. For this purpose, a certain level of autonomy is given to the system. The structure was tested in indoor environments for different kinds of operators. A maximum time delay of 2s was successfully coped with.
High-accuracy global localization filter for three-dimensional environments
Authors: Martín Fernando , Moreno Luis , Garrido Santiago , Blanco Dolores 
Published: July 2011

SUMMARYThe localization problem in mobile robotics can be defined as the search of the robot's coordinates in a known environment. If there is no information about the initial location, we are talking about global localization. In this work, we have developed an algorithm that solves this problem in a three-dimensional (3D) environment using evolutionary computation concepts. The method has been called RELF-3D and has many features that make it very robust and reliable: thresholding and discarding mechanisms, different cost functions, effective convergence criteria, and so on. The resulting global localization module has been tested in numerous experiments and the most important improvement obtained is the accuracy of the method, allowing its application in manipulation tasks.
The role of gesture in designing
Authors: Visser Willemien , Maher Mary Lou 
Published: July 2011

AbstractThis paper introduces the special issue of AI EDAM on the role of gesture in designing. It starts with the context of the papers submitted and a summary of the papers accepted. We then introduce gesture studies, one of the two main domains with which this Special Issue is concerned. We do not introduce design research: we suppose the readers of AI EDAM are familiar with this domain. After this general introduction to the domain of gesture studies, we provide an overview of gestures in design, that is, the research environment of the papers in this Special Issue. We then discuss some dimensions on which these papers differ, as well as some on which they are related.
Using speech to identify gesture pen strokes in collaborative, multimodal device descriptions
Authors: Herold James , Stahovich Thomas F. 
Published: July 2011

AbstractOne challenge in building collaborative design tools that use speech and sketch input is distinguishing gesture pen strokes from those representing device structure, that is, object strokes. In previous work, we developed a gesture/object classifier that uses features computed from the pen strokes and the speech aligned with them. Experiments indicated that the speech features were the most important for distinguishing gestures, thus indicating the critical importance of the speech–sketch alignment. Consequently, we have developed a new alignment technique that employs a two-step process: the speech is first explicitly segmented (primarily into clauses), then the segments are aligned with the pen strokes. Our speech segmentation step is unique in that it uses sketch features for locating segment boundaries in multimodal dialog. In addition, it uses a single classifier to directly combine word-based, prosodic (pause), and sketch-based features. In the second step, segments are initially aligned with strokes based on temporal correlation, and then classifiers are used to detect and correct two common alignment errors. Our two-step technique has proven to be substantially more accurate at alignment than the existing technique that lacked explicit segmentation. It is more important that, for nearly all cases, our new technique results in greater gesture classification accuracy than the existing technique, and performed nearly as well as the benchmark manual speech–sketch alignment.
Emergency oral rabies vaccination of foxes in Italy in 2009–2010: identification of residual rabies foci at higher altitudes in the Alps
Authors: MULATTI P. , MÜLLER T. , BONFANTI L. , MARANGON S. 
Published: July 2011

SUMMARYFollowing a resurgence of fox rabies in northeastern Italy in 2008–2009, two emergency oral rabies vaccination (ORV) campaigns were performed in the Alpine mountain ranges in 2009 and 2010 using aerial distribution to prevent the disease from spreading further inland. Vaccine baits were distributed only below the freezing point altitude, 1000 m above sea level (a.s.l.) in December 2009–January 2010 and 1500 m a.s.l. in April–May 2010, to avoid repeated freeze–thaw cycles. Spatial analysis unexpectedly identified fox rabies hotspots above the threshold altitudes, probably representing local residual rabies foci which may have contributed to maintaining the infectious cycle in areas not vaccinated at higher altitudes. Based on the results obtained, in May 2010, the second ORV campaign was extended to include threshold altitudes of up to 2300 m a.s.l. to eliminate residual foci. The observations made may help in the formulation of ORV strategies in countries sharing similar topographical features.