bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of Social Determinants of Health on Stroke Survivor Discharge Location from an Acute Comprehensive Stroke Center
Authors: Migliarese Sara , Adams Tiffany , McCloskey Kiran , Henao David , Gregory Chere 
Published: February 2025

Abstract

Objective
This study aimed to assess the influence of social determinants of health on discharge location after an acute care hospital admission due to stroke.

Design
Retrospective analyses assessed electronic medical records (EMR) from an acute facility in North Carolina dating from November 20, 2014, to December 29, 2019 (N = 4,603). All subjects were diagnosed with stroke and received at least one physical therapy session. Multinomial stepwise logistic regression assessed the clinical and demographic factors associated with being discharged to each home care with services, skilled nursing facilities, or inpatient rehabilitation in comparison to home care without services.

Results
After accounting for clinical variables, being younger, having a significant other, holding private insurance, being female, and being of Hispanic ethnicity were associated with a greater probability of being discharged to home care without services. Compared to White patients, Black patients were more likely to be discharged to home care with services than home care without services. Intraclass correlations indicated that zip code of residence may influence likelihood of being discharged to a skilled nursing facility.

Conclusion
This analysis demonstrates that social determinants of health are associated with discharge location.
A Systematic Review and Meta-Analysis of the Association Between Pain-Related Fear and Pain Intensity in Experimental Pain Models
Authors: Kutash Lindsay A. , Sayer MacKenzie A. , Delahanty Douglas L. 
Published: February 2025

Objective
Pain is a multifaceted experience influenced by sensory and affective factors, with significant variability in perception among individuals that affects pain management and recovery. Pain-related fear (PRF) has been linked to a number of adverse outcomes in clinical pain populations, including pain intensity. Experimental studies offer unique insight into the direction and magnitude of the PRF–pain intensity relationship; however, results of relevant studies are mixed. The present meta-analysis aimed to synthesize findings of laboratory studies investigating PRF and pain intensity in order to estimate the pooled effect of this relationship as well as to evaluate potential moderators and competing variables contributing to between-study variability (preregistration ID: CRD42023432110).

Methods
Searches in PubMed, PsychINFO, and Cochrane Library yielded 27 independent samples, totaling 1633 participants, that reported correlations between PRF and pain intensity in healthy, pain-free individuals.

Results
Results revealed a pooled effect size that was positive and significant (r = 0.22, p < .001), with the magnitude of the relationship varying by PRF measurement tool (Q = 8.48, p = .004). Specifically, studies that used the Fear of Pain Questionnaire (McNeil and Rainwater, 1998) reported more robust effect sizes than alternative PRF measurement tools. Although competing psychological variables were related to both PRF and pain intensity, PRF predicted pain intensity over and above these factors.

Conclusion
The present results indicate a unique positive effect of PRF, as measured in the absence of an ongoing pain experience, on later perceptions of pain intensity. The implications for future experimental pain studies and clinical translation are discussed.
Depression and Low Social Support Mediate the Association of Marital Stress and 12-Month Cardiac-Specific Quality of Life in Young Adults With Acute Myocardial Infarction
Authors: Zhu Cenjing , Dreyer Rachel P. , Li Fan , Spatz Erica S. , Caraballo César , Mahajan Shiwani , Raparelli Valeria , Leifheit Erica C. , Lu Yuan , Krumholz Harlan M. , Spertus John A. , D’Onofrio Gail , Pilote Louise , Lichtman Judith H. 
Published: February 2025

Objective
This study explored whether and how depression and low social support mediate the association between marital stress and cardiac-specific quality of life (QoL) in young adults (≤55 years) with acute myocardial infarction (AMI).

Methods
Data were obtained from 1593 married/partnered AMI survivors aged 18–55 years enrolled in the VIRGO study (2008–2012). Marital stress (Stockholm Marital Stress Scale) was self-reported at 1 month post-AMI and categorized as absent/moderate or severe. Significant depressive symptoms (Patient Health Questionnaire-9 score ≥10), low social support (ENRICHD Social Support Instrument score ≤3 on ≥2 items and total score ≤18), and cardiac-specific QoL (Seattle Angina Questionnaire) were assessed at 12 months post-AMI. Natural direct effect (NDE) of marital stress and indirect effects (NIE) through depression or low social support and the proportion mediated (PM) were estimated by causal mediation methods with adjustment for baseline QoL and sociodemographic factors.

Results
There was a significant direct effect from severe marital stress to lower cardiac-specific QoL after covariate adjustment (NDE = −4.83, 95% CI = −6.98 to −2.49, p < .001). Categorized depression and low social support mediated 11.5% (NIE = −0.63, 95% CI = −1.15 to −0.10, p = .014) and 13.5% (NIE = −0.69, 95% CI = −1.10 to −0.29, p < .001) of the total effect between marital stress and QoL, respectively. When examined as continuous scores, both mediator effects were of borderline significance (PHQ-9: PM = 38.2%, p = .086; social support: PM = 46.1%, p = .051).

Conclusions
Depression and low social support partially mediated the relationship between marital stress and cardiac-specific QoL, underscoring the need for further exploration of additional mediators to inform more comprehensive secondary prevention strategies.
Adverse Childhood Experiences Influence Longitudinal Changes in Leptin But Not Adiponectin
Authors: Matovic Sara , Rummel Christoph , Neumann Elena , McGrath Jennifer , Gouin Jean-Philippe 
Published: February 2025

Objective
Adverse childhood experiences (ACEs) are associated with a greater risk of obesity and cardiometabolic disease. Adipokines, including leptin and adiponectin, play vital roles in biological processes linked to obesity and cardiometabolic risk. The adiponectin/leptin ratio may represent a marker of impaired hormonal regulation of adipose tissue. Prior cross-sectional studies suggest patterns of higher plasma leptin and lower adiponectin among adults who have experienced ACEs. This study addresses whether ACEs influence longitudinal changes in leptin, adiponectin, and the adiponectin/leptin ratio, after accounting for current chronic stress and adiposity.

Methods
This longitudinal study included 192 middle-aged mothers (mean age = 46.78 years) experiencing higher (n = 108) and lower (n = 84) chronic caregiving stress. Adipokines and adiposity were measured at three timepoints: T1 (baseline), T2 (15 months later), and T3 (30 months after T1). ACEs were assessed retrospectively using the Childhood Trauma Questionnaire.

Results
Mixed-effect models showed that leptin and adiponectin increased over time. Greater ACEs exposure was associated with larger increases in leptin over time, but it was not related to adiponectin or the adiponectin/leptin ratio. Current caregiving stress was not related to leptin and adiponectin levels and did not interact with ACEs in predicting adipokine levels. Mediation analyses revealed that increases in waist circumference partially mediated the association between ACEs and increases in leptin over time.

Conclusions
ACEs may increase vulnerability to cardiometabolic risk in midlife caregiving mothers through its influence on longitudinal changes in leptin and central adiposity.
Prognostic Impacts of Depression and Inflammatory Factors in Pancreatic Cancer Patients
Authors: Chen Po See , Shen Yang-Chen , Lin Cheng-Feng , Liu Ping-Yen , Lin Peng-Chan , Su Pei-Fang , Yen Chia-Jui , Shan Yan-Shen 
Published: February 2025

Objective
This study explores the potential connections between clinical depression, inflammation, and cancer progression in pancreatic cancer patients.

Methods
Conducted from May 2021 to May 2023 at the National Cheng Kung University Hospital Clinical Data Warehouse, this prospective study involved 279 pancreatic cancer patients. The nine-item self-reported Patient Health Questionnaire (PHQ-9) was used to assess depressive symptoms. The study focused on the correlation between clinically significant depression (PHQ-9 scores >10), levels of inflammatory factors, and patient survival rates.

Results
At the time of diagnosis, 34.0% of the patients exhibited clinically significant depression. Analysis using Fixed Effects in Generalized Linear Mixed Models (GLMM) revealed a notable link between log-transformed C-reactive protein (ln CRP) levels with occurrence of depression (odds ratio [OR] = 1.274, p = .010). Furthermore, a univariate Cox proportional hazard model with time-varying covariates indicated a correlation between clinically significant depression and decreased overall survival (hazard ratio [HR] = 6.245, p < .001). A multivariate Cox model also showed significant associations of both ln CRP levels (HR = 1.966, p = .030) and clinically significant depression (HR = 3.611, p = .028) with survival outcomes.

Conclusions
The findings highlight a complex interplay between inflammation, depression, and survival in pancreatic cancer patients. However, the study is limited by the lack of control over all potential confounders, such as chronic conditions, which could independently influence both depression and inflammatory biomarkers.
Epilepsy Surgery Education: A Survey of US Epilepsy Fellowship Program Directors
Authors: Katyal Roohi , Sheikh Irfan S. , Gutierrez Camilo , Sinha Saurabh R. , Day B. Keith , Gavvala Jay R. , Sheth Sameer A. , Wirrell Elaine , Beniczky Sándor , Nascimento Fábio A. 
Published: February 2025

Purpose:
To understand the current state of epilepsy surgery education delivered to epilepsy fellows in the United States.

Methods:
An online survey focused on characteristics of epilepsy surgery education was distributed to all 93 epilepsy fellowship program directors listed on the ACGME website (accessed in May 2022). Programs were stratified per the number of fellows currently enrolled: 0 to 3 (group A) and ≥4 (group B).

Results:
Forty-one of 93 (44%) epilepsy fellowship programs were included in the study. The average number of resective surgeries, ablations, or corpus callosotomies per year was mostly 0 to 30 (54%) in group A and mostly >30 (80%) in group B (P = 0.05). The average number of intracranial implantations per year was mostly 0 to 20 (58%) in group A and mostly >20 (80%) in group B (P < 0.05). The average number of neurostimulation implantations per year was 15 (range 0–90; vagal nerve stimulation), 7 (range 0–25; responsive neurostimulation), and 4 (range 0–10; deep brain stimulation). In 78% of programs, fellows are not required to present a minimum number of epilepsy surgery cases in multidisciplinary conference before graduation. Roughly half of programs (51%) reported not using objective measures to assess fellow competency in epilepsy surgery.

Conclusions:
Our results suggest significant variability in epilepsy surgery volume and, consequently, fellow exposure to surgical cases and lack of standardized, objective measures in fellow teaching and assessment in the field of epilepsy surgery across programs in the United States. We advocate development of a core epilepsy surgery curriculum including minimum standards at the national level.
Resting calcium ion fluxes protect cells from fast mitochondrial fragmentation, cell stress responses, and immediate transcriptional reprogramming
Authors: Fecher Caroline , Sodmann Annemarie , Schlott Felicitas , Jaepel Juliane , Schmitt Franziska , Lengfelder Isabella , Bischler Thorsten , Nieswandt Bernhard , Winklhofer Konstanze F. , Blum Robert 
Published: February 2025

AbstractHomeostatic calcium ion (Ca2+) fluxes between the endoplasmic reticulum, cytosol, and extracellular space occur not only in response to cell stimulation but also in unstimulated cells. Using murine astrocytes as a model, we asked whether there is a signaling function of these resting Ca2+-fluxes. The data showed that endoplasmic reticulum (ER) Ca²⁺ depletion, induced by sarcoplasmic/endoplasmic reticulum Ca²⁺-ATPase (SERCA) inhibition, resulted to prolonged Ca²⁺ influx and mitochondrial fragmentation within 10 to 30 minutes. This mitochondrial fragmentation could be prevented in Ca2+- free medium or by inhibiting store-operated Ca2+entry (SOCE). Similarly, attenuation of STIM proteins, which are vital ER Ca2+sensors, protected mitochondrial morphology. On the molecular level, ER Ca2+depletion, achieved either by removing extracellular Ca2+or through acute SERCA inhibition, led to changes in gene expression of about 13% and 41% of the transcriptome within an hour, respectively. Transcriptome changes were associated with universal biological processes such as transcription, differentiation, or cell stress. Strong increase in expression was observed for the transcription factor ATF4, which is under control of the kinase PERK (EIF2AK3), a key protein involved in ER stress. Corroborating these findings, PERK was rapidly phosphorylated in Ca2+-free medium or after acute pharmacological inhibition of SOCE. In summary, resting, homeostatic Ca2+fluxes prevent immediate- early cell stress and transcriptional reprogramming.
Short- and long-term effects of uterine disease on oocyte developmental capacity in postpartum dairy cows
Authors: Caldeira M. O. , McDonald K. S. , Martinez E. S. M. , Moraes J. G. N. , Sellmer Ramos I. , Poock S. E. , Ortega M. S. , Lucy M. C. 
Published: February 2025

ABSTRACTThe hypothesis was that early postpartum uterine disease would reduce the developmental capacity of oocytes thus contributing to the reduced fertility of dairy cows with uterine disease. Dairy cows were diagnosed healthy or with metritis at 7 to 10 d postpartum. The reproductive tract was collected at approximately 1 mo (Exp. 1) or approximately 80 or 165 d (Exp. 2) postpartum for the collection of cumulus-oocyte complexes (COC). The COC were matured, co- incubated with sperm for fertilization, and cultured to the blastocyst stage (8 d) in vitro. For Exp.1, the disease diagnosis (healthy or metritis) did not affect the number of collected COC or the subsequent embryo development to the blastocyst stage. The presence of purulent material in the uterine lumen (endometritis) at time of oocyte collection, however, was associated with a reduced cleavage rate evaluated 3 d following fertilization. For Exp. 2, there was no effect of disease diagnosis (healthy or metritis) on the number of COC or their subsequent development. Reduced cleavage rates were observed in COC retrieved from cows slaughtered at 80 d postpartum, but not at 165 d postpartum, and this reduction was associated with a vaginal microbiome indicative of uterine disease at 4 to 5 wk postpartum. Regression analyses that included plasma haptoglobin or energy metabolite concentrations or uterine bacterial genera abundance did not explain a large percentage of the variation in oocyte development in vitro. We conclude that there is an effect of uterine disease at one month postpartum on the oocyte and its capacity for development (Exp. 1) and this effect may be present at 80 d postpartum (Exp. 2). In later postpartum cows (165 d postpartum; Exp. 2) there was no effect of uterine disease on in vitro oocyte development.GRAPHICAL ABSTRACTHIGHLIGHTSOocytes collected at 1 month postpartum from dairy cows with endometritis (purulent uterine lumen) had a lower cleavage rate following in vitro fertilization when compared with oocytes collected from healthy cows (Exp. 1).Oocytes collected at approximately 80 d postpartum from dairy cows with evidence of uterine disease at 4 to 5 wk postpartum had a lower cleavage rate following in vitro fertilization but this disease-associated difference was not observed when oocytes were collected from cows later postpartum (approximately 165 d postpartum; Exp. 2).Regardless of the study (Exp. 1 or 2), uterine disease primarily affected the percentage of oocytes that cleaved after fertilization.Statistical associations between circulating metabolites or relative abundance of uterine bacteria were either not significant or explained only a small percentage of the variation in the in vitro embryo development in either experiment.
Unravelling Sex Differences in the Genetic Architecture of Anxiety: A Genome-Wide Association Study in the UK Biobank
Authors: Hu Jihua , Lupton Michelle K. , Byrne Enda M. , Martin Nicholas G. , Whiteman David C. , Olsen Catherine M. , Thomas Jodi T. , Medland Sarah E. , Grasby Katrina L. , Mitchell Brittany L. 
Published: February 2025

AbstractBackgroundAnxiety disorders show striking sex differences in prevalence, symptoms, and clinical characteristics, shaping how they manifest and are experienced.MethodsThis study investigated the genetic basis of these differences using sex-specific genome-wide association studies (GWAS). GWAS were conducted separately in females (47,054 cases, 57,027 controls) and males (23,819 cases, 55,030 controls) within the UK Biobank. Functional annotation, sex-specific polygenic scores (PGS), and genetic correlations were performed to assess genetic differences and functional implications.ResultsIn females, 10 lead SNPs were significantly associated with anxiety, compared to four in males. Among these, three lead SNPs in females and two in males demonstrated significantly different effect sizes across sexes. In addition, SNP-based heritability estimates were significantly different and gene-based tests and functional prioritization identified different genes associated with anxiety in females and males. However, whole-genome analyses, including genetic correlations across sexes and PGS predictions, revealed no significant genetic differences between the sexes. Sex combined GWAS of several traits showed a trend toward sex differences with anxiety in genetic correlation analysis. Sex-specific GWAS on waist-to-hip ratio (WHR) adjusted for BMI enabled separate genetic correlation analyses with anxiety, revealing significant sex differences that were not observed in the combined GWAS.ConclusionsThis study is the first sex-specific GWAS of anxiety. While the overall genetic architecture of anxiety is largely shared between sexes, our findings reveal distinct sex-specific genetic associations and correlations, highlighting the value of analysing the sexes separately to uncover genetic signals that may be masked in sex-combined samples.
MilkOligoCorpus: a semantically annotated resource for knowledge extraction on mammalian milk oligosaccharides
Authors: Rumeau Mathilde , Courtin Marine , Bossy Robert , Sauvion Clara , Loux Valentin , Ba Mouhamadou , Knudsen Christelle , Combes Sylvie , Nédellec Claire , Deléger Louise 
Published: February 2025

AbstractMilk oligosaccharides are bioactive components that regulate the composition of the neonatal microbiota and exert immunomodulatory functions. Their beneficial effects depend on their structure. Numerous studies have shown intra- and inter-species variation in the structural composition and concentration of these compounds in mammalian milk, yet the biological significance of such variation remains poorly understood. Automated natural language processing methods are promising tools for extracting and gathering structured data from unstructured texts to get insight into the biological significance of milk oligosaccharide variation across mammals. These methods require training and evaluation on manually annotated text corpora. While annotated corpora exist for chemical substances, none are specifically designed for training natural language processing models to extract information on milk oligosaccharides.To this end, we propose MilkOligoCorpus, a new gold standard for milk oligosaccharide composition in mammalian species. MilkOligoCorpus’ annotation scheme is a rich entity/relation model designed to describe the diversity pattern of milk oligosaccharides according to female factor variability and to help better understand the structure-related function of milk oligosaccharides. MilkOligoCorpus consists of 30 PubMed texts fully annotated with entities related to individuals, samples, oligosaccharides and oligosaccharide quantification linked by binary and n-ary relationships. To address data interoperability across disparate publications and databases, four terminological resources were also developed to assign unique identifiers to the entities, supported by external ontologies.This paper presents the creation of the MilkOligoCorpus and its associated schema, along with the development of annotation guidelines and terminological resources. We also present experimental results obtained by baseline information extraction models on the corpus.
Integrating Natural Language Processing to Assess Effect of Loneliness and Social isolation on Cognitive Decline in Dementia: A Retrospective Cohort Analysis
Authors: Myers James , Stafford Tom , Koychev Ivan , Perneczky Robert , Bandmann Oliver , Vaci Nemanja 
Published: February 2025

INTRODUCTIONThe study aimed to compare cognitive trajectories between patients with reports of social isolation and loneliness and those without.METHODSReports of social isolation, loneliness, and Montreal Cognitive Assessment (MoCA) scores were extracted from dementia patients’ medical records using Natural Language Processing models and analysed using mixed-effects models.RESULTSLonely patients (n = 382) showed lower MoCA scores throughout the disease (B = - 0.83, t = −2.64, p = 0.008). Socially isolated patients (n = 523) experienced faster cognitive decline six months before diagnosis (B = −0.21, t = −2.18, p = 0.029), but were comparable to controls (n = 3912) before this period. This led to lower MoCA scores at diagnosis (B = −0.69, t = −2.53, p = 0.011) and in later stages.DISCUSSIONLower cognitive levels in lonely and socially isolated patients suggest that these factors may contribute to dementia progression.