bluuebunny/crossref_metadata_2025_split huggingface dataset:
Autologous protein solution inhibits MMP‐13 production by IL‐1β and TNFα‐stimulated human articular chondrocytes
Authors: Woodell‐May Jennifer , Matuska Andrea , Oyster Megan , Welch Zachary , O'Shaughnessey Krista , Hoeppner Jacy 
Published: March 2011

AbstractCatabolic inflammatory cytokines are prevalent in osteoarthritis (OA). The purpose of this study was to evaluate an autologous protein solution (APS) as a potential chondroprotective agent for OA therapy. APS was prepared from platelet‐rich plasma (PRP). The APS solution contained both anabolic (bFGF, TGF‐β1, TGF‐β2, EGF, IGF‐1, PDGF‐AB, PDGF‐BB, and VEGF) and anti‐inflammatory (IL‐1ra, sTNF‐RI, sTNF‐RII, IL‐4, IL‐10, IL‐13, and IFNγ) cytokines but low concentrations of catabolic cytokines (IL‐1α, IL‐1β, TNFα, IL‐6, IL‐8, IL‐17, and IL‐18). Human articular chondrocytes were pre‐incubated with the antagonists IL‐1ra, sTNF‐RI, or APS prior to the addition of recombinant human IL‐1β or TNFα. Following exposure to inflammatory cytokines, the levels of MMP‐13 in the culture medium were evaluated by ELISA. MMP‐13 production stimulated in chondrocytes by IL‐1β or TNFα was reduced by rhIL‐1ra and sTNF‐RI to near basal levels. APS was also capable of inhibiting the production of MMP‐13 induced by both IL‐1β and TNFα. The combination of anabolic and anti‐inflammatory cytokines in the APS created from PRP may render this formulation to be a potential candidate for the treatment of inflammation in patients at early stages of OA. © 2011 Orthopaedic Research Society Published by Wiley Periodicals, Inc. J Orthop Res 29: 1320–1326, 2011
Effect of shoulder taping on maximum shoulder external and internal rotation range in uninjured and previously injured overhead athletes during a seated throw
Authors: McConnell Jenny , Donnelly Cyril , Hamner Samuel , Dunne James , Besier Thor 
Published: March 2011

AbstractThe purpose of our study was to investigate whether shoulder taping affects shoulder kinematics in injured and previously injured overhead athletes during a seated throw. Twenty‐six overhead college athletes threw a handball three times with and without tape, while seated on a chair. An 8‐camera Vicon Motion Capture system recorded markers placed on the upper limb and trunk during each of the throwing conditions. Scaled musculoskeletal models of the upper limb were created using OpenSim and inverse kinematics used to obtain relevant joint angles. Shoulder taping had no main effect on external (ER) and internal (IR) rotation range (ROM) of the shoulder, but a significant interaction effect was found (p = 0.003 and 0.02, respectively), depending on previous injury status, whereby both the ER and IR ROM of the shoulder in the group of previously injured athletes decreased when taped (143–138° and 54–51°, respectively), but increased in the group who had never been injured (131–135° and 42–44°, respectively). Maximum abduction range and ball velocity were not affected by the application of shoulder taping, regardless of previous injury status. Thus, application of shoulder taping has a differential effect on maximum shoulder ER and IR ROM during throwing depending on previous injury status. These findings have implications for returning athletes to sport after injury and for screening athletes at risk of injury. © 2011 Orthopaedic Research Society Published by Wiley Periodicals, Inc. J Orthop Res 29: 1406–1411, 2011
Adolescent distress in traumatic stress research: Data from the National Survey of Adolescents‐Replication
Authors: Zajac Kristyn , Ruggiero Kenneth J. , Smith Daniel W. , Saunders Benjamin E. , Kilpatrick Dean G. 
Published: March 2011

AbstractSmall numbers of adults report distress in response to traumatic stress surveys. Less is known about adolescent research participants. We examined distress in response to a survey on traumatic stress using data from the National Survey of Adolescents‐Replication, a nationally representative sample of 3,614 youth aged 12–17 years. Although 204 (5.7%) adolescents found some questions distressing, only 8 (0.2%) remained upset at the end of the interview, and 2 (<0.1%) wished to speak to a counselor. Adolescents reporting traumatic experiences or mental health problems were significantly more likely to report distress compared to those not endorsing such problems. Significantly more girls (7.5%) reported distress than boys (3.9%). Findings suggest that survey questions about trauma pose minimal risk to adolescents.
A Highly Efficient Iron‐Mediated AGET ATRP of Methyl Methacrylate Using Fe(0) Powder as the Reducing Agent
Authors: Qin Jian , Cheng Zhenping , Zhang Lifen , Zhang Zhengbiao , Zhu Jian , Zhu Xiulin 
Published: March 2011

AbstractA new method, AGET ATRP mediated by an iron(III) catalyst using Fe(0) powder as a reducing agent and MMA as a model monomer, is reported. The polymerizations can be carried out in the absence or presence of a limited amount of air and show the features of a “living”/controlled radical polymerization. MMA conversions of 90.3 and 80.0% can be obtained in 3.5 and 4.0 h in the absence/presence of a limited amount of air, respectively, for the iron‐mediated AGET ATRP with a molar ratio of [MMA]0/[EBiB]0/[FeCl3 · 6H2O]0/[PPh3]0/[Fe(0)]0 = 600:1:0.5:2:0.1 at 90 °C. PMMA with molecular weights of 55 060 and 47 790 g · mol−1 and with molar‐mass dispersity of 1.24 and 1.28, respectively, can be obtained correspondingly. magnified image
Implementing an employee performance management system in a nonprofit organization
Authors: Becker Karen , Antuar Nicholas , Everett Cherie 
Published: March 2011

AbstractNonprofit organizations are not exempt from the imperatives of employee attraction, retention, and motivation. As competition for staff, donors, and funding increases, the need to manage employee performance will continue to be a critical human resource management issue. This article outlines a study of the introduction of a performance management system in an Australian nonprofit organization and analyzes its design and implementation. It explores how performance management can be introduced and used effectively within a nonprofit environment to benefit staff and the organization. However, the use of performance management is not without its challenges, and the research also identified initial employee resistance and a resulting initial spike in labor turnover. However, findings indicate that if nonprofit organizations are willing to undertake consultation with staff and ensure that the organization's specific context, values, and mission are reflected in the performance management system, it can be a useful tool for managers and a direct benefit to employees.
IL‐32 up‐regulation is associated with inflammatory cytokine production in allergic rhinitis
Authors: Jeong Hyun‐Ja , Shin Seung‐Youp , Oh Hyun‐A , Kim Min‐Ho , Cho Joong‐Saeng , Kim Hyung‐Min 
Published: March 2011

AbstractIL‐32 is a described pro‐inflammatory cytokine produced by T lymphocytes, natural killer cells, monocytes, and epithelial cells. However, the specific mechanism of IL‐32 on allergic rhinitis (AR) has not been elucidated. Here, we report a significant increase of IL‐32 protein and mRNA in the nasal mucosa of AR patients. In addition, in nasal mucosa tissue from AR patients, the level of IL‐32 production correlated with inflammation, IL‐1β, IL‐18, and granulocyte‐macrophage colony‐stimulating factor (GM‐CSF). In an AR animal model, IL‐32 significantly increased IgE and inflammatory cytokine levels. IL‐32 expression was induced by recombinant human GM‐CSF via activation of caspase‐1 in eosinophils. In addition, depletion of IL‐32 prevents the production of inflammatory cytokines in eosinophils. In conclusion, IL‐32 is an important cytokine involved in the inflammation of AR. The regulation of IL‐32 expression may form the basis of a new strategy for the treatment of AR. Copyright © 2011 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
Second neoplasm in children treated in EORTC 58881 trial for acute lymphoblastic malignancies: Low incidence of CNS tumours
Authors: Renard Marleen , Suciu Stefan , Bertrand Yves , Uyttebroeck Anne , Ferster Alice , van der Werff ten Bosch Jutte , Mazingue Françoise , Plouvier Emannuel , Robert Alain , Boutard Patrick , Millot Frédéric , Munzer Martine , Mechinaud Françoise , Lescoeur Brigitte , Baila Liliana , Vandecruys Els , Benoit Yves , Philippet Pierre ,   on behalf of EORTC Children Leukaemia Group (CLG)
Published: March 2011

AbstractBackgroundIntensive chemotherapy has markedly improved the survival of children with acute lymphoblastic leukaemia (ALL) or lymphoblastic lymphoma (LL). Evaluation of late effects and analysis of factors contributing to their occurrence has become of major importance. Second neoplasm (SN) belongs to the most severe late events.ProcedureWe report the incidence of SN which occurred in patients recruited in EORTC trial 58881 for children with ALL or LL. The front‐line treatment regimen was adapted from the BFM protocol, but did not include cranial radiotherapy, even in patients with initial involvement of the central nervous system. A total of 2,216 patients were recruited, of whom 2,136 achieved complete remission (CR).ResultsAt a median follow‐up of 7.5 years, 22 (1%) patients developed a SN: 20 during or after completion of front‐line therapy and 2 in second CR, after relapse treatment including haematopoietic stem cell transplantation (HSCT). Ten patients developed acute myeloblastic leukaemia. Only one SN, a glioblastoma, was a brain tumour. Other SN were: two Hodgkin lymphomas, one non‐Hodgkin lymphoma, two thyroid cancers, one osteosarcoma, two soft tissue sarcomas, one Ewing sarcoma, one cutaneous histiocytosis and one peritoneal carcinomatosis. The cumulative incidences of SN at 5, 8 and 13 years after registration were 0.8% (SE 0.2%), 1.0% (SE 0.2%) and 3.0% (SE 1.9%), respectively.ConclusionThe overall incidence rate of SN is comparable to that reported previously. In spite of short follow‐up time, the low incidence of brain tumours might be related to the omission of cranial radiotherapy. Pediatr Blood Cancer 2011;57:119–125. © 2011 Wiley‐Liss, Inc.
Using the Bracken Basic Concept Scale and Bracken Concept Development Program in the assessment and remediation of young children's concept development
Authors: Bracken Bruce A. , Panter Janet E. 
Published: March 2011

AbstractThis article presents a historical description of and research related to the development, validation, and combined use of the multiple editions of the Bracken Basic Concept Scale and its companion curriculum, the Bracken Concept Development Program. In tandem, the scale and curriculum were designed to assess and teach more than 300 basic language concepts that are fundamental to understanding and describing the world in which young children live. Basic concepts are represented in early childhood educational standards across all 50 states, and this article provides the theoretical and practical basis for understanding conceptual domains, subcategories, and the manner in which psychologists and early childhood educators can effectively assess and teach these concepts. © 2011 Wiley Periodicals, Inc.
Assessment of preschool early literacy skills: Linking children's educational needs with empirically supported instructional activities
Authors: Lonigan Christopher J. , Allan Nicholas P. , Lerner Matthew D. 
Published: March 2011

AbstractThe importance of the preschool period in becoming a skilled reader is highlighted by a significant body of evidence that preschool children's development in the areas of oral language, phonological awareness, and print knowledge is predictive of how well they will learn to read once they are exposed to formal reading instruction in elementary school. Although there are now a number of empirically supported instructional activities for helping children who are at risk of later reading difficulties to acquire these early literacy skills, limitations in instructional time and opportunities in most preschool settings require the use of valid assessment procedures to ensure that instructional resources are utilized efficiently. In this article, we discuss the degree to which informal, diagnostic, screening, and progress‐monitoring assessments of preschool early literacy skills can inform instructional decisions by considering the strengths and weaknesses of each approach to assessment. © 2011 Wiley Periodicals, Inc.
Proteomic characterization of a selenium‐metabolizing probiotic Lactobacillus reuteri Lb2 BM for nutraceutical applications
Authors: Lamberti Cristina , Mangiapane Erika , Pessione Alessandro , Mazzoli Roberto , Giunta Carlo , Pessione Enrica 
Published: March 2011

AbstractSelenium (Se), Se‐cysteines and selenoproteins have received growing interest in the nutritional field as redox‐balance modulating agents. The aim of this study was to establish the Se‐concentrating and Se‐metabolizing capabilities of the probiotic Lactobacillus reuteri Lb2 BM, for nutraceutical applications. A comparative proteomic approach was employed to study the bacteria grown in a control condition (MRS modified medium) and in a stimulated condition (4.38 mg/L of sodium selenite). The total protein extract was separated into two pI ranges: 4–7 and 6–11; the 25 identified proteins were divided into five functional classes: (i) Se metabolism; (ii) energy metabolism; (iii) stress/adhesion; (iv) cell shape and transport; (v) proteins involved in other functions. All the experimental results indicate that L. reuteri Lb2 BM is able to metabolize Se(IV), incorporating it into selenoproteins, through the action of a selenocysteine lyase, thus enhancing organic Se bioavailability. This involves endo‐ergonic reactions balanced by an increase of substrate‐level phosphorylation, chiefly through lactic fermentation. Nevertheless, when L. reuteri was grown on Se a certain degree of stress was observed, and this has to be taken into account for future applicative purposes. The proteomic approach has proven to be a powerful tool for the metabolic characterization of potential Se‐concentrating probiotics.
Surface Morphology in the Early Stages of Plasma Polymer Film Growth from Amine‐Containing Monomers
Authors: Michelmore Andrew , Martinek Petr , Sah Vasu , Short Robert D. , Vasilev Krasimir 
Published: March 2011

AbstractThe manner by which plasma polymers grow in the very first stages of deposition is a topic which has been almost overlooked. We show using atomic force microscopy (AFM) and X‐ray photoelectron spectroscopy (XPS) that in the early stages of plasma deposition there are significant differences in the way plasma polymers grow from two amine‐containing compounds onto silicon wafers. By AFM it is shown that films grown from n‐heptylamine (HA) initially show ‘island‐like’ growth before a continuous smooth film is formed. In contrast, films from allylamine grow smoothly from the very earliest stages. XPS data show substantial differences of plasma polymer chemistry in close proximity to the silicon surface manifested in the formation of ${\rm NH}_{{\rm 3}}^{{\rm + }} $ and NOx species which are more abundant in films of HA. We present a possible explanation for these results based upon post‐plasma surface phenomena in the case of HA.
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HIV sexual transmission and microbicides
Authors: Ariën Kevin K. , Jespers Vicky , Vanham Guido 
Published: March 2011

AbstractPathogens often rely on the contacts between hosts for transmission. Most viruses have adapted their transmission mechanisms to defined behaviours of their host(s) and have learned to exploit these for their own propagation. Some viruses, such as HIV, the human papillomavirus (HPV), HSV‐2 and HCV, cause sexually transmitted infections (STIs). Understanding the transmission of particular viral variants and comprehending the early adaptation and evolution is fundamental to eventually inhibiting sexual transmission of HIV. Here, we review the current understanding of the mechanisms of sexual transmission and the biology of the transmitted HIV. Next, we present a timely overview of candidate microbicides, including past, ongoing and future clinical trials of HIV topical microbicides. Copyright © 2011 John Wiley & Sons, Ltd.
Aptamers: turning the spotlight on cells
Authors: López‐Colón Dalia , Jiménez Elizabeth , You Mingxu , Gulbakan Basri , Tan Weihong 
Published: March 2011

AbstractThis article is a review of the development and application of aptamer probes for cell imaging. Aptamers selected against whole cells have been modified with different fluorescent dyes and nanomaterials, such as gold nanoparticles, quantum dots, and superparamagnetic iron oxide, for their use as imaging probes of live cells. These probes have been successfully used for cell imaging both in vitro and in vivo by optical imaging, magnetic resonance imaging (MRI), computed tomography (CT), and positron‐emission tomography (PET). In this article, we discuss the development of different aptamer‐based probes currently available for imaging of live cells and their applications in the biomedical field. WIREs Nanomed Nanobiotechnol 2011 3 328–340 DOI: 10.1002/wnan.133This article is categorized under:

Diagnostic Tools > In Vitro Nanoparticle-Based Sensing
Diagnostic Tools > In Vivo Nanodiagnostics and Imaging
Nanotechnology Approaches to Biology > Nanoscale Systems in Biology
Management of Right Colonic Uncomplicated Diverticulitis: Outpatient Versus Inpatient Management
Authors: Park Hyoung‐Chul , Kim Byoung Seup , Lee Bong Hwa 
Published: March 2011

AbstractBackgroundInitial conservative management may be the mainstay of therapy for uncomplicated right colonic diverticulitis. However, definitive treatment guidelines have not yet been established. In this study, we assessed the efficacy of outpatient management versus inpatient management for preventing recurrence of this condition.MethodsBetween 2007 and 2009, a total of 103 patients were consecutively enrolled at the first attack of uncomplicated right colonic diverticulitis. In this prospective observational study, 40 patients underwent an outpatient management regimen consisting of oral antibiotics (for 4 days), and 63 patients underwent an inpatient management regimen that included bowel rest and intravenous antibiotics (for 7–10 days). The treatment was selected by the patient. Failure to respond to therapy and the incidence of recurrence of this condition were assessed.ResultsBoth groups of patients were treated successfully, and their symptoms were relieved. The patients were followed up for a median time of 21 months. Of the 40 patients with short‐term oral antibiotic therapy on an outpatient basis, disease recurrence was observed in 4 patients (10%). Of these four patients, one underwent surgery and the remaining three were treated nonoperatively. Of the 63 patients on inpatient management, recurrence was observed in 7 patients (11%). Of these seven patients, one underwent surgery and the remaining six were treated nonoperatively.ConclusionsOutpatient management with short‐term oral antibiotic therapy for the treatment of uncomplicated right colonic diverticulitis is as effective as inpatient management in regard to preventing disease recurrence.
Art. VIII.—Corrections of the Canon of Ptolemy, required in order to place it in harmony with the Solar Eclipses of Jan. 11th, B.C. 689, and May 28th B.C. 585
Authors: Bosanquet J. W. 
Published: March 2011

In a paper which I had the honour of reading before this Society On the eighth of July last, I endeavoured to establish—First, that the remarkable astronomical phenomenon which occurred in the fourteenth year of Hezekiah, King of Jndah—viz., the retrograde motion of the sun's shadow on the dial, or steps, of the king's palace at Jerusalem, accompanied by some visible wonder in the heavens—must have been the effect of an eclipse of the sun. Secondly, that if the phenomenon was indeed caused by a solar eclipse, it must have been one combining the following distinguishing characters, viz.:—1st, That it should have been visible at Jerusalem.2nd, That it should have occurred within about twenty days of the winter solstice.3rd, That it should have occurred about noon-day.4th, That the occultation should have been on the upper limb of the sun.
Art. X.—Some Account of the Senbyú Pagoda at Mengún, near the Burmese Capital, in a Memorandum
Authors: Sladen E. H. , Yule Henry 
Published: March 2011

1. The Pagoda was built in the reign of king Bodo Piyah, in the Burmese year 1178 (A.D. 1816), by his grandson, Noungdau Gyee, now known as Bagyeedau Piyah, which specifies his relationship as paternal uncle to the present reigning king.2. It is situated at Mengoon, on the west bank of the Irrawaddy, a couple of hundred yards only from the huge brick ruin which is known as the Mengoon pagoda.
Art. V.—On the Age of the Ajantá Caves.
Authors: Bahadur Rájendralála Mitra Rai 
Published: March 2011

In a paper published in volume xlvii. of the Journal of the Asiatic Society of Bengal, I attempted to identify the nationality of some foreign figures depicted in the rock-cut caves at Ajantá. The conclusions I arrived at were:—1st. That the figures with long flowing coats and sugarloaf hats in one of the pictures were Persians.2nd. That the principal personages in three “Drinking scenes” were Bactrians.3rd. That the scenes represented phases of Indian life from 1800 to 2000 years ago.
Art. IV.—A Sculptured Tope on an old Stone at Dras, Ladak
Authors: Simpson William 
Published: March 2011

Dras is a village on the banks of a stream of the same name, about the distance of one march beyond the Bul-tul pass, on the road from Cashmere to Leh. There are two sculptured stones at this place, and as Cunningham has described them in his work on Ladak, I shall quote from him:“On the side of the road, between the hamlet of Styalbo and the village of Drás, there are two pillars of granitic mica-slate, which the people call Chomo, or ‘The Women,’ but which, I believe, have no connection with Tibetan Buddhism, as the nearly obliterated inscriptions are in Kashmiri Tákri, and not in Tibetan characters. The eastern pillar has one principal figure, a four-armed female, and two attendant females, one on each side, and each with one leg bent. They all wear necklaces, earrings, amulets, and anklets. On the pedestal are several small kneeling figures with their hands raised and joined in attitudes of prayer. This pillar is six feet nine inches high, one foot six inches broad, and one foot thick. The western pillar has the same principal figure, also a four-armed female, with two attendant females on each side. This pillar is six feet high, two feet nine inches broad, and one foot thick. From the style of these figures, as well as from the nature of the alphabetical characters, I have no hesitation in stating my opinion that they are Brahminical statues erected by some Kashmirian Hindus. This opinion is strengthened by the fact that there is a third undoubted Hindu pillar standing close to them, which I believe to be a Sati pillar. On one side is sculptured a horseman, which is the usual emblem, placed on the piUar of a Rajputni Sati, to denote that her husband was a soldier. On the back of the pillar there is an inscription of eight lines in Kashmirian Tákri, which I am. unable to translate satisfactorily.”—pp. 381–82.