bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Relationship between the Level of Coagulative Function Hypertensive Disorder Complicating Pregnancy
Authors: Lin Z , Fang B , Zhu D , Wang D , Lin X , Yu X , Wang F , Yang C 
Published: May 2024

Background and Aim:
Preeclampsia, a pregnancy complication associated with significant maternal and perinatal mortality and morbidity, has been found to be closely linked to dysfunction in the blood coagulation–fibrinolysis system. However, the relationship between hematologic data and severity and onset time of preeclampsia remains unclear. This study aimed to identify specific hematologic parameters in both preeclamptic and normotensive pregnant women and determine their potential significance in the pathogenesis of preeclampsia.

Materials and Methods:
A total of 112 patients with gestational hypertension disease were divided into two groups: early-onset preeclampsia (32 cases) and late-onset preeclampsia (80 cases). A control group of 82 normotensive pregnant women matched for age and parity was also selected. Blood samples were collected from all participants to test for specific hematologic parameters.

Results:
Mild and severe preeclampsia were associated with lower hemoglobin level (P = 0.01 and P = 0.03, respectively), higher mean platelet volume (P = 0.01 and P = 0.01, respectively) and fibrinogen (P = 0.01 and P = 0.01, respectively), and shorter prothrombin time (P = 0.02 and P = 0.01, respectively) and activated partial thromboplastin time (P = 0.01 and P = 0.02, respectively).

Conclusion:
These findings have provided evidence on the hematologic coagulative actors in the pathogenesis and severity of preeclampsia.
Determination of Breast Cancer Risk and Knowledge Levels in Women: The Case of Cyprus
Authors: Mammadov B , Yarıcı F 
Published: May 2024

Background:
Breast cancer is the type of cancer that is seen all over the world and ranks first among female cancers in terms of incidence and cause of death.

Objective:
This research was conducted to determine the breast cancer risk level and breast cancer knowledge level in women living in Northern Cyprus.

Methods:
The study, which was planned as a relational survey, was carried out as web-based. The research was completed with 657 adult female participants living in Northern Cyprus who volunteered to participate in the study. In order to collect data, the first section includes the introductory features, the second section includes the "Breast Cancer Risk Assessment Form" for determining breast cancer risk levels, the third section includes the "Comprehensive Breast Cancer Knowledge Test" to determine the breast cancer knowledge levels of the participants, and the fourth section includes the "Champion Health Belief Model Scale” was used.

Results:
It was determined that 95.2% of women were in the low risk group for breast cancer. The knowledge test mean score is 12.05, and it can be said that the scores obtained are above the average (min:4- max:18). It was found that 55.7% of the women knew how to do Breast Self-Examination (BSE), but only 15.4% of them regularly performed BSE every month. It was found that 80.9% of the women never had mammography and their knowledge scores increased with increasing education level (p< 0.001) and there was a significant relationship between non-smokers and their knowledge levels (p< 0.01).

Implications for Practice:
Despite the high scores of women in knowledge tests, it was observed that the frequency of applying BSE and having mammography was very low. Regardless of the risk factors for breast cancer, the importance of regular check-ups and BSE for every woman should be taught to women by health professionals, and group trainings should be planned for women who do not have training on this subject.
Parental Knowledge and Attitudes to Childhood Hearing Loss and Hearing Services in the Kingdom of Saudi Arabia
Authors: Khurayzi Tawfiq A. , Gadi Wala H. , Alandijani Hamza A. , Almutairi Abdulaziz. B , Zogel Basem A. , Akoor Atheer A. , Hakami Alshomokh M. , Alsallum Manar H. 
Published: May 2024

Abstract

Background:
Childhood hearing is critical to the development of speech, language, and social skills. Hearing loss (HL) can interfere with learning and requires early detection and management. This study aimed to evaluate parental knowledge with attitudes toward childhood HL, and available hearing services across the Kingdom of Saudi Arabia.

Methods:
This cross-sectional study was conducted among parents of children from different regions of Saudi Arabia. Data were collected using an online self-administered questionnaire and analyzed using SPSS version 23. This study examined the relationships among socio-demographic characteristics and knowledge and attitudes toward HL using a Chi-square test.

Results:
Assessment of the prevalence of various aspects of knowledge and attitudes among parents toward childhood HL revealed that 732 (58.4%) participants had a good level of knowledge, while 521 (41.6%) had poor knowledge. Furthermore, the attitude analysis revealed that 871 (69.5%) participants expressed a good attitude, whereas 382 (29.5%) had a poor attitude. A significant association was noted between age group and attitude (P = 0.005).

Conclusion:
The findings demonstrated a gap in the level of knowledge and significant variation regarding a certain set of risk factors responsible for HL, which highlighted the need for establishing educational programs across the Kingdom to mitigate these harms and promote parental awareness. Parental attitudes toward auditory services were satisfactory; however, efforts are needed to familiarize parents with newborn hearing screening programs that are widely available in the Kingdom.
Mitigative effect of Naringenin in bleomycin induced systemic sclerosis model; role of Notch signaling pathway
Authors: Morshedy Dina I M , Atef Marwa M , Soliman Nema A , Fouda Abdallah M 
Published: May 2024

Background
An immunological, proinflammatory, and vascular disorder called systemic sclerosis (SSc) frequently leading to progressive tissue fibrosis. Reactive oxidizing species are thought to have a substantial influence on disease initiation and progression, based on a variety of studies. Also, Notch signaling is known to modulate fibroblast homeostasis, angiogenesis, and lymphocyte development.

Aim
This experimental study was designed to shed light on the possible ameliorating mechanism of naringenin as antioxidant in bleomycin-induced SSc model via focusing on Notch signaling cascade.

Materials and methods
50 male albino mice were employed for the test, while being allocated randomly to one of five equal groups as follows: Control group (group I), Naringenin-treated group (group II), Bleomycin-treated group (group III), and group IV (Naringenin/Bleomycin co-treated group) and group V (Bleomycin followed by Naringenin treated group). Plasma hydrogen peroxide level, skin tissue hydrogen peroxide and hydroxyproline levels were measured using colorimetric assay. A Disintegrin and metalloproteinase domain containing protein 17 and neuregulin 1 levels in skin tissue were measured by Enzyme-linked immunosorbent assay. Histological evaluation was also performed.

Results
Plasma hydrogen peroxide, skin tissue hydrogen peroxide, hydroxyproline, a Disintegrin and metalloproteinase domain containing protein 17 and neuregulin 1 levels in the bleomycin-treated group were significantly increased than other studied groups. Naringenin administration in parallel with the induction mitigated the obtained biochemical changes and protected against the chemical induction of SSc.

Conclusion
Naringenin could protect against bleomycin-induced SSc through its antioxidant role.
Long-term outcome of local muscles transposition for the functional restoration of large upper or lower lip defects
Authors: Alsharkawy Kareem , Mostafa Ibrahim , Elmelegy Nader 
Published: May 2024

Background
Although more than 200 techniques have been reported for the reconstruction of their and lower lip defects since 1000 BC, none of them is ideal.
Local flaps come at the expense of extra skin scarring and, in some cases, the surgeon may be confronted with the lack of sufficient tissues for the reconstruction of large defects.
It has been reported that several methods exist for performing near-total lip reconstruction. Currently, free micro-vascular tissue transfer and local flap repair (the Bernard von Burrow-Webster method) are the two most prominent methods.

Aim
To evaluate the functional results of using local muscles transposition-assisted dermal fat flap and muco-buccal flap to treat upper or lower lip defects.

Patients and methods
This study was carried out on 128 patients, who presented to us with malignant tumors affecting the lips.

Results
Lip defect sizes ranged from four to 6 cm in length. There was no evidence of flap failure, and the aesthetic and functional outcomes are very well. All patients healed successfully, and 100% of the flaps survived. No cases of microstomia were reported.

Conclusion
The use of local muscle transposition, assisted with dermal fat flap and muco-buccal flap technique, showed excellent results in regaining, oral competence, and lip mobility, and as much as possible, increasing the aesthetic outcome.
Ear keloid treatment using subepidermal excision-assisted electrophotobiomodulation
Authors: Alsharkawy Kareem , Mostafa Ibrahim , Elmelegy Nader 
Published: May 2024

Background
Keloids are challenging problems that have an aesthetic and psychological impact on patients who are genetically susceptible, especially in exposed areas. Moreover, treatment modalities are known to have a high incidence of recurrence.

Aim
We present our experience in subepidermal excision combined with E-light therapy (electrophotobiomodulation) in the treatment of ear keloids.

Patients and methods
Thirty-five patients who were presented with ear keloids were included. Under local anesthesia, a flap of keloid epidermis and a thin layer of the scar underneath were raised from the fibrous keloid core which, in turn, was extirpated leaving a thin margin of scar tissue (subepidermal excision).
2 weeks later after complete healing, all patients were subjected to a combination of radiofrequency (RF) and intense pulsed light (IPL) sessions (E-light). The outcome was assessed by the incidence of keloid recurrence at any time within the 2-year follow-up.

Result
The age of the patients ranged from 12 to 52 years with a median age of 34 years. There were 25 females (71%) and 10 males (29%). The average number of E-light therapy sessions was 6 (range 4–8 treatment sessions) at 4-week intervals. Keloid size had an average of 1 × 3 cm. In the 2-year follow-up, only two cases reported keloid recurrence. Of the patients, 33 did not report recurrence with a success rate of 95%.

Conclusions
Subepidermal keloid excision with a combination of radiofrequency and intense pulsed light is a promising multimodality treatment for ear keloids.
Histological study of the effect of hydroxychloroquine sulfate on the retina and the possible protective role of propolis in adult male albino rats
Authors: Noseir Ghada Adel Fetoh , Elkaliny Heba Hassan , Elhafez Amal Ali Ahmed Abd , Salah Ehsan Farouk 
Published: May 2024

Background
Hydroxychloroquine sulfate (HCS) is a widely used antimalarial drug. Recently, it garnered attention about its possible effect against COVID-19. Retinopathy is one of its dangerous side effects which may be untreated. Propolis is a substance made by honeybees and has a neuroprotective effect.

Aim
The study aimed to assess the impact of HCS on the retina and the possible ameliorative role of propolis in adult male albino rats.

Materials and methods
In all, 32 adult male albino rats were separated into four groups; group (I): the control group, group II: rats had received 100 mg/kg propolis for 12 weeks, group III: the HCS dose of 55 mg/kg/day had been administered to the rats for a period of 10 days, group IV: rats had received 55 mg/kg/day of HCS concomitant with 100 mg/kg propolis for 10 days and then propolis was continued to complete 12 weeks. Retinal specimens were obtained and processed for histological and morphometric analyses.

Results
Group III revealed vacuolations of photoreceptors; nuclei are widely separated in the outer and inner nuclear layers Also nuclei are darkly pigmented in the inner nuclear layer and the ganglion cell layer. Statistical analysis showed that there was a significant drop in the average number of ganglion cells when contrasted with the control group. These changes were markedly ameliorated in group HCS and propolis-treated group.

Conclusion
Hydroxychloroquine sulfate induced damaging effects on the rat retina and receiving propolis could attenuate these effects.
Predictive accuracy of ultrasonography on upper ends of radius and ulna in age estimation in a sample of Egyptian population
Authors: Seada Donia A A , Fayed Manar M , Elkhouly Radwa M , Hashem Ahmed A 
Published: May 2024

Background
Forensic age estimation is considered a prime focus of forensic anthropological analysis of living and human skeletal remains.

Aim
This study aimed to assess the accuracy of ultrasonography (US) in bone age estimation and to compare the predictability of age detection using ultrasound on the upper ends of the radius and ulna in a sample of Egyptian population.

Patients and methods
This cross-sectional study was conducted on 111 Egyptian volunteers of both sexes aged from 10 to 25 years old and subjected to the sonographic examination of the elbow joint. The volunteers were grouped into three age groups: group 1 (from 10 up to <12 years), group 2 (from 12 up to 16 years), and group 3 (> 16 up to 25 years).

Results
There was no statistically significant difference between both sexes concerning the age groups suggested by the stage of the epiphyseal union of the upper ends of the radius and ulna detected by US examination. The Kappa agreement test showed that there was a good agreement between the age estimated by the US examination based on the stage of the epiphyseal union of proximal ends of radius and ulna and the official age (Kappa=0.756, and 0.630, respectively).

Conclusion
US can be used as a suitable alternative modality for age estimation. The studied bone ends showed good agreement between the official age and the US estimated age. The proximal radius was with the highest agreement.
Histological study on the toxic effect of titanium dioxide nanoparticles on the prostate gland of adult albino rats and the protective role of coenzyme Q10
Authors: Elewa Nourhan G , Elabd Shereen S , Moustafa Khaled A , Shalaby Nawar M 
Published: May 2024

Background
Titanium dioxide nanoparticles have numerous clinical and commercial applications. Coenzyme Q10 has antioxidant and free radical-scavenging capabilities in addition to functions like vitamins.

Aim
To identify changes in the ventral prostatic lobe of adult albino rats exposed to titanium dioxide nanoparticles and to evaluate the possible protective role of coenzyme Q 10.

Materials and methods
Forty adult male albino rats were used in this study. Group I was the control, Group II received coenzyme Q10 at a dose of 20 mg/kg, Group III received titanium dioxide nanoparticles at a dose of 600 mg/kg, and Group IV received both coenzyme Q10 and nanoparticles. Prostate glands sections were stained with hematoxylin and eosin. A morphometric study and statistical analysis were performed on the epithelial height.

Results
Sections of group III showed some histological abnormalities in the form of widely spaced prostatic acini, an increase in the amount of connective tissue stroma, with numerous dilated blood vessels and perivascular cellular infiltration. The mean height of the prostatic epithelium in group III was significantly higher than in the control group. Prostatic epithelial height was found to be significantly lower in group IV as compared to group III.

Conclusion
Titanium dioxide nanoparticles induce changes in the prostatic ventral lobe which can be ameliorated by coenzyme Q10 supplementation.
Efficacy of corneal debridement combined with intrastromal voriconazole injection as adjunctive therapy for recalcitrant fungal keratitis
Authors: Elmohamedy Sarah E , Ghoneim Ahmed M , Sabry Moataz M , Khater Mohammad M 
Published: May 2024

BackgroundFungal keratitis is a serious cause of blindness worldwide, especially in developing countries. Many trial were done to accelerate healing and improve outcome of recalcitrant fungal keratitis unresponsive to standard clinical treatment.AimTo evaluate the efficacy of corneal debridement combined with intrastromal voriconazole injection as an adjunctive treatment for recalcitrant mycotic keratitis.Patients and methodsThis prospective randomized interventional study was carried out on 40 eyes of 40 patients with resistant fungal corneal ulcers. Patients were equally divided into two groups: in one group, corneal debridement combined with intrastromal voriconazole in the same setting (group A) was done as adjunctive therapy to topical treatment, and in the other group, only topical antifungal therapy was used guided with culture and sensitivity results (group B). All patients were subjected to ophthalmic examination and were followed-up daily for the first week then weekly till complete healing.ResultsHealing was achieved in 95% of cases of group A at the fourth week while healing was achieved in group B in only 55% of cases at the same duration with a statistically significant difference between both groups (X2=14.983,P= 0.002). No cases required amniotic membrane transplantation (AMT) in group A while 4 cases in group B required AMT due to thinning.ConclusionsCorneal debridement combined with intrastromal injection of voriconazole may offer a good option as adjunctive therapy to traditional topical therapy for recalcitrant fungal keratitis and may shorten the duration of the treatment with faster recovery of vision.
The beneficial effects of Berberine on experimental model of Acrylamide induced nephrotoxicity
Authors: El Gendy Dalia A M , Nasef Nahla A , El-Ghaffar Heabah Nehal A , Gaafar Nagah K , Dawood Lamees M 
Published: May 2024

Background
Acrylamide (AA) is an industrial monomer which is used in many industries. Dietary or occupational exposure affects high percentage of population. It causes multi-organ toxicity including neurotoxicity, hepatotoxicity and nephrotoxicity via induction of oxidative stress and inflammation. AA induced nephrotoxicity is a major health problem that needs our concern. Berberine (BBR) is an alkaloid that has nephroprotective effects as being an antioxidant and an anti-inflammatory.

Aim
The aim of this work was to shed light on autophagy and nucleotide binding oligomerization domain like receptor family pyrin domain containing 3 (NLRP3) inflammasome formation and to assess the ameliorating effect of BBR as antioxidant, anti-inflammatory and autophagy modulator on experimental model of AA induced nephrotoxicity.

Materials and methods
This study was done on 50 male rats, which were randomly divided equally into 5 groups: control group; Acrylamide group (received AA only); Berberine-Acrylamide co-treatment group (received AA and BBR simultaneously); prophylaxis group (given BBR alone for 10 days followed by BBR and AA for another 10 days); and Berberine group (received BBR only).

Results
Administration of BBR as a prophylactic agent enhanced kidney function, restored electrolyte balance, suppressed oxidative stress and NLRP3 inflammasome and induced mitophagy. However, its administration as a co-treatment with AA showed ameliorating effect. The histopathological changes were consistent with the biochemical results.

Conclusion:
BBR could protect against AA induced nephrotoxicity through reduction of oxidative stress, suppression of NLRP3 inflammasome and induction of mitophagy. The usage of BBR as a protective drug against the progression of nephrotoxicity seems to be promising.
Can Microfinance-Based Poverty Alleviation Programs Help Patients with Severe Mental Illness?
Authors: Javed Afzal , Naeem Farooq 
Published: May 2024

Background:
While the social security programs offer financial assistance to patients with severe mental illness in high-income countries, no such systems exist in low- and middle-income countries. During recent years, poverty alleviation programs have been found to alleviate poverty in many countries. However, such programs have not been tried in persons with severe mental illness. We report 1-year outcomes of a microfinance program to alleviate poverty in patients with schizophrenia in a low-income country.

Objectives:
The objectives were to assess the feasibility and acceptability of a poverty alleviation program and to study the effect of the program on clinical and financial variables.

Methods:
Twenty-five (25) unemployed, young persons (19–35) with severe mental illness living with the family were recruited into a microfinance-based poverty alleviation program. Feasibility was assessed through recruitment and retention. Psychopathology and functioning were assessed through Positive and Negative Syndrome Scale (PANSS), Brief Psychiatric Rating Scale, and Global Assessment of Functioning at baseline and 12 months.

Results:
The program was feasible and acceptable, with excellent recruitment and retention rates. There were statistically significant improvements in PANSS-positive symptoms (P < 0.000), PANSS-negative symptoms (P < 0.000), PANSS-general score (P < 0.000), and functioning (P < 0.001). At 12 months, participants earned an average of $USD 40/month, with an average of $USD 10 spent on medication, $USD 12.5 on loan repayment, and $USD 17.5 contribution to family living.

Conclusions:
Poverty alleviation programs can be used to help younger persons with severe mental illness. However, this study has numerous limitations, and there is a need to conduct definitive trials in this area.
Patronage und deutsche Literatur im 18. Jahrhundert
Authors: Ghanbari Nacim 
Published: May 2024

Eine in unserer Gegenwart verfemte Beziehung, die im 18. Jahrhundert individuelle Lebensläufe und das literarische Leben wesentlich mitbestimmte Patronage ist eine schriftintensive soziale Praxis. Sie ermöglicht die Aufnahme in soziale Netzwerke und die Entstehung literarischer Öffentlichkeiten. Briefe und Ratgeberliteratur über Briefe, aus freundschaftlicher Bewunderung und Kritik entstandene Texte, an Gönnerinnen und Gönner adressierte Lebensgeschichten erschaffen eine literarische Sphäre, die eigenen Gesetzen folgt. Glanz und Elend der Patronage als Ermöglichungsbedingung literarischen Überlebens sind nirgends schärfer gezeichnet als bei Anna Louisa Karsch und Jakob Michael Reinhold Lenz. Hier zeigt sich paradigmatisch, wie sich Patronage auf die Rezeption, Zirkulation und Überlieferung literarischer Texte auswirkt.