bluuebunny/crossref_metadata_2025_split huggingface dataset:
Orlistat accentuates the fat-induced fall in blood pressure in older adults
Authors: Tai Kamilia , Gentilcore Diana , Jones Karen L. , Banh Lisa , Gilja Odd Helge , Hammond Angela J. , Feinle-Bisset Christine , Horowitz Michael , Chapman Ian M. 
Published: March 2011

Postprandial hypotension may be influenced by the digestion of fat. The aim of the present study was to evaluate the hypothesis that products of fat digestion mediate the hypotensive response to fat. In part A of the study, nine healthy older subjects were studied on three separate occasions in randomised order. Blood pressure, heart rate (HR), plasma TAG and gastric emptying were measured following the ingestion of equivolaemic drinks: (1) 300 ml of high-fat drink (88 % fat); (2) fat drink mixed with 120 mg orlistat (lipase inhibitor); (3) water (control). In part B of the study, ten healthy older subjects were studied on two separate occasions. Blood pressure, HR, plasma TAG and superior mesenteric artery flow were measured during 90 min intraduodenal infusions of 10 % intralipid (2·7 ml/min), with and without 120 mg orlistat. Oral fat ingestion was associated with decreases in systolic and diastolic blood pressures (both P = 0·0001) that were greater when orlistat was co-administered (both P < 0·05), and an increase in HR (P = 0·0001) that was inhibited by orlistat co-administration (P < 0·03). Gastric emptying was slowed by oral fat digestion, and orlistat administration inhibited this slowing (P < 0·04). Intraduodenal fat infusion was not associated with changes in blood pressure but increased HR (P < 0·0001), an effect attenuated by orlistat (P < 0·05). In conclusion, orlistat potentiates the hypotensive response to oral fat in older adults, possibly as a result of faster gastric emptying of fat. The results do not support a role for fat digestion in lowering blood pressure.
A new species ofExrima,synonymy of four species ofAphotopontius, StygiopontiusandRhogobius, and record of first copepodid stage of Dirivultidae (Copepoda: Siphonostomatoida) from deep-sea hydrothermal vents of the East Pacific Rise (13°N)
Authors: Ivanenko Viatcheslav N. , Defaye Danielle , Segonzac Michel , Khripounoff Alexis , Sarrazin Jozée , Ferrari Frank D. 
Published: March 2011

Females of the new speciesExrima walterisp. nov. were found in sediment trap samples deployed over different sites of the East Pacific Rise (13°N) at 2600 m depth. Four traps were deposited during the HOPE99 cruise (1999) and recovered during the AMISTAD (1999) cruise on the research vessel ‘L'Atalante’. The new species is distinguished from congeners,E. singulaHumes, 1987 andE. dolichopusHumes, 1987, by the following derived characters: first somite of the urosome with 3 (one dorsal and two lateral) stout conical extensions; distal endopodal segment on the swimming leg 4 broad. In addition, many specimens of copepodids I and lecithotrophic nauplii, identified as belonging to Dirivultidae gen. sp., were found in the samples of all sediment traps. This is the first record of copepodids I and of a nauplius of dirivultids from the Pacific Ocean. Study of type and additional material collected during different Ifremer cruises at different vent sites (HERO91, EXOMAR, PHARE and MoMARETO) required synonymy of four species ofAphotopontiusHumes, 1987,StygiopontiusHumes, 1987 andRhogobiusHumes, 1987.Aphotopontius rapunculusHumes and Segonzac, 1998 is transferred to the genusRhogobiusbecause it possesses all presumed derived attributes of this genus: last abdominal somite with lobes at sides of anal operculum; second segment of antennal endopod elongate and slender. A new study of the type material suggests that:Aphotopontius temperatusHumes, 1997 is a synonym ofA. atlanteusHumes, 1996;Stygiopontius lumigerHumes, 1989 is a synonym ofS. sentiferHumes, 1987 whileS. bulbisetigerHumes, 1996 is a synonym ofS. pectinatusHumes, 1987. Females of the three synonymized species were found to be sub-adult females at copepodid V. Leg 6 on these specimens is one seta located dorsolaterally on the posterior part of the genital somite. This position for leg 6 is unknown for copepodid V of other siphonostomatoids whose leg 6 is located ventrally at copepodid V; the dorsolateral position is presumed derived and shared by the dirivultid generaAphotopontiusHumes, 1987 andStygiopontiusHumes, 1987. A new key to the Dirivultidae genera is presented.
Rigidity and mapping class group for abstract tiling spaces
Authors: KWAPISZ JAROSLAW 
Published: March 2011

AbstractWe study abstract self-affine tiling actions, which are an intrinsically defined class of minimal expansive actions of ℝdon a compact space. They include the translation actions on the compact spaces associated to aperiodic repetitive tilings or Delone sets in ℝd. In the self-similar case, we show that the existence of a homeomorphism between tiling spaces implies conjugacy of the actions up to a linear rescaling. We also introduce the general linear group of an (abstract) tiling, prove its discreteness, and show that it is naturally isomorphic with the (pointed) mapping class group of the tiling space. To illustrate our theory, we compute the mapping class group for a five-fold symmetric Penrose tiling.
Seeking respite: issues around the use of day respite care for the carers of people with dementia
Authors: ROBINSON ANDREW , LEA EMMA , HEMMINGS LYNN , VOSPER GILLIAN , McCANN DAMHNAT , WEEDING FELICITY , RUMBLE ROGER 
Published: March 2011

ABSTRACTAgeing in Place policies have transferred responsibility for many frail elderly people and those living with dementia from residential to in-home care. Despite this placing a greater obligation on families, in Australia carers continue to under-use day respite services. This qualitative design study identified issues around the use of day respite care from the perspective of the family carer, focusing on barriers to attendance and strategies to facilitate attendance. Telephone interviews were held in 2007 with Tasmanian carers whose family member refused to attend day respite care (ten carers) and those whose family member attended (17). Carers considering day respite care were often overwhelmed by the quantity of information, confused about the process, and worried about the recipient's safety in an unfamiliar environment. They felt anxious about public acknowledgement of the condition leading to fear of embarrassment. Day respite care users appreciated the break it provided them and the opportunity for their family member to socialise. To facilitate a greater uptake of day respite care, reliable information sources and strategies to help carers deal with the emotions they face on a daily basis, together with a wider social acceptance of dementia, are important. Furthermore, carers need an opportunity to talk with others, enabling them to gain support from those who have successfully introduced a family member to day respite care.
A gendered lifecourse examination of sleep difficulties among older women
Authors: WALKER RUTH B. , LUSZCZ MARY A. , HISLOP JENNY , MOORE VIVIENNE 
Published: March 2011

ABSTRACTRecent research has suggested that understanding and addressing the high prevalence of sleep difficulties in older women requires going beyond a purely physiological focus to address the role of social contextual pressures and demands. We take a gendered lifecourse approach to explore how sleep difficulties have evolved and how their management might reflect the position of older women in society more broadly. We conducted in-depth interviews with 12 oldest-old (average age 86) community-dwelling women who currently experienced sleep difficulties. Five themes emerged from the analysis: significant life stages; contingent lives; daily concerns in relation to ageing; attitudes and responses of women and general practitioners; and stigma and sleeping pills, which provided a conceptual framework through which to explain the reality of sleep difficulties for these women. For all women, sleep difficulties were not related to physical aspects such as pain or discomfort, but were largely shaped by demands associated with family relationships at different times in the lifecourse. Furthermore, our findings suggest that responses by women themselves, and health professionals, reflect a sense of stigma around sleep difficulties and use of sleeping pills. More emphasis on the social contextual explanations underpinning sleep difficulties might lead to better prevention and treatment of such problems, and increase quality of life.
Bad data equals bad policy: how to trust estimates of ecosystem loss when there is so much uncertainty?
Authors: FRIESS D. A. , WEBB E. L. 
Published: March 2011

SummaryScientific evidence will be better incorporated into conservation action and environmental policy if it is deemed credible by decision-makers. However, huge uncertainties are inherent in large-scale ecosystem statistics. Two wetland case studies relating to mangrove areal extent in Peninsular Malaysia and saltmarsh loss in the UK indicate the major causes of information uncertainty, relating to poor methodological description, traceability and assumptions associated with the use of grey literature. Furthermore, potentially inaccurate information can be propagated throughout the research community and gain ‘proof by assertion’, especially if the information originates from an authoritative source. Researchers must better consider implicit and explicit uncertainty and be critical of secondary information. Future information production requires the use of rigorous peer-reviewed methodologies in order to decrease and quantify error. Such steps will increase the credibility of scientific evidence, so researchers can better contribute to a two-way science and policy deliberation approach.
Resolving management conflicts: could agricultural land provide the answer for an endangered species in a habitat classified as a World Heritage Site?
Authors: SMITH REBECCA K. , RYAN EMMA , MORLEY EMMA , HILL RUSSELL A. 
Published: March 2011

SUMMARYThe short-interval fires required to promote grazing for large herbivores within the Cape Floristic Region World Heritage Site are detrimental to plant diversity. At the same time, longer interval fires significantly reduce graze quality. Conservation managers thus face an enormous challenge when the herbivores are also a conservation priority, since the competing conservation objectives are difficult to reconcile. Population growth rates of genetically important populations of endangered Cape mountain zebra (Equus zebra zebra) are low or declining following management focused on their fynbos habitat. Investigation of spatial and temporal habitat use and the diet of Cape mountain zebra, focusing on the use of land historically converted to agricultural grassland within fynbos in De Hoop Nature Reserve (South Africa), determined factors limiting populations and facilitated development of management strategies. Zebras selected grassland over other habitat types, despite grassland accounting for only a small proportion of the reserve. Grasses also made up the greatest proportion of diet for zebras throughout the year. Time spent on grasslands increased with grass height and was likely to have been influenced by grass protein levels. It is likely that grazing resources are a limiting factor for zebra, and so options for improving and/or increasing grassland at De Hoop should be considered. Translocation of surplus males to other conservation areas, reductions in other herbivore populations and targeted burns to increase grassland availability all offer short-term solutions. However, the acquisition of agricultural grassland adjacent to reserves is likely to be a viable long-term management strategy for this and other genetically important Cape mountain zebra populations. Low conservation priority habitats, such as farmland, should be considered for other management conflicts, as they have the potential to play a vital role in conservation.
Entamoeba species associated with chronic diarrhoea in Pakistan
Authors: YAKOOB J. , ABBAS Z. , BEG M. A. , NAZ S. , KHAN R. , JAFRI W. 
Published: March 2011

SUMMARYWe determined the prevalence of Entamoeba (E.) histolytica, E. dispar and E. moshkovskii in patients with chronic diarrhoea associated with abdominal pain or discomfort mimicking irritable bowel syndrome. Stool samples were collected from 161 patients with chronic diarrhoea and from 157 healthy controls. Stool microscopy with modified trichrome stain, culture and polymerase chain reaction (PCR) for Entamoeba spp. differentiation was performed. Microscopy demonstrated Entamoeba cysts in 44% (57/129) of patients with diarrhoea compared to 29% (44/151) of controls (P=0·009). In patients with diarrhoea, PCR for E. histolytica was positive in 9% (11/129) (P=0·008), E. dispar in 19% (24/129) (P=0·117) and E. moshkovskii in 19% (24/129) (P<0·001). E. histolytica and E. moshkovskii were significantly associated with diarrhoea while E. dispar was found equally in both groups.
Psittacosis outbreak after participation in a bird fair, Western France, December 2008
Authors: BELCHIOR E. , BARATAUD D. , OLLIVIER R. , CAPEK I. , LAROUCAU K. , DE BARBEYRAC B. , HUBERT B. 
Published: March 2011

SUMMARYIn December 2008, three hospitalized cases of suspected psittacosis infection were notified by respiratory disease clinicians from a local hospital to the Regional Epidemiology Unit of Pays de la Loire, France. They all had attended a bird fair. A retrospective cohort study was conducted among exhibitors and organizers to identify potential risk factors in relation to this fair. Environmental and veterinary investigations were implemented to trace potential sources of infection. We identified two confirmed, two probable and 44 possible cases among participants. The attack rate in exhibitors and organizers was 38% (33/86). The median incubation period was 11 days (range 6–22 days). Individuals located in two particular sectors of the showroom were found to be at double the risk of developing psittacosis (relative rate 2·1, 95% confidence interval 1·03–4·18) than those in other sectors. Pooled faecal samples of birds belonging to a possible case exhibitor tested positive for Chlamydiaceae by PCR. Ventilation conditions in the showroom were inadequate. This investigation allowed the formulation of recommendations to prevent psittacosis in bird exhibitions which are held weekly in France.
Combining current land use and farmers' knowledge to design land-use requirements and improve land suitability evaluation
Authors: Ziadat Feras M. , Sultan Kais A. 
Published: March 2011

AbstractLand suitability analysis is very important to assess and propose the most suitable land-use options. The reliability of land suitability evaluation is controlled by choosing the most limiting land characteristics and their ratings for the proposed land utilization types (LUTs). This study aims at examining the possibility of using current land use and farmers' knowledge as a starting point to suggest and/or modify land evaluation criteria, and to improve the land suitability evaluation process. The potential suitability of land for five LUTs (open range, improved range, rainfed barley, drip-irrigated vegetables and drip-irrigated trees) was evaluated near Al-Mafraq in Jordan using the maximum limitation method. The results indicated variable agreement levels between potential land suitability and current land use for different LUTs. Sixteen farms were selected to represent different cases of disagreement between potential suitability and current land use and were visited to explore the farmers' improved management practices adopted to overcome land-use limitations. Using proposed criteria, only 1% of the study area was highly suitable for drip irrigation, whereas most of the area was moderately or marginally suitable for other uses. This represents the conventional land evaluation procedures, which, in most cases, overlook the farmers' knowledge and practices that are adopted in a particular area to overcome biophysical limitations. The ratings for different land characteristics were modified based on comparisons with current land use, and by referring to farmers’ adopted management practices. Using modified criteria, the highly suitable area for drip-irrigated vegetables increased by 18% and the highly suitable area for drip-irrigated trees increased by 25%. The results emphasized that the consideration of the farmer's indigenous knowledge and current land use improve the land evaluation process, which leads to better utilization of limited land resources in fragile environments.
PRIMe: a method for characterization and evaluation of pleiotropic regions from multiple genome-wide association studies
Authors: Huang Jie , Johnson Andrew D. , O'Donnell Christopher J. 
Published: March 2011

Abstract
Motivation: The concept of pleiotropy was proposed a century ago, though up to now there have been insufficient efforts to design robust statistics and software aimed at visualizing and evaluating pleiotropy at a regional level. The Pleiotropic Region Identification Method (PRIMe) was developed to evaluate potentially pleiotropic loci based upon data from multiple genome-wide association studies (GWAS).
Methods: We first provide a software tool to systematically identify and characterize genomic regions where low association P-values are observed with multiple traits. We use the term Pleiotropy Index to denote the number of traits with low association P-values at a particular genomic region. For GWAS assumed to be uncorrelated, we adopted the binomial distribution to approximate the statistical significance of the Pleiotropy Index. For GWAS conducted on traits with known correlation coefficients, simulations are performed to derive the statistical distribution of the Pleiotropy Index under the null hypothesis of no genotype–phenotype association. For six hematologic and three blood pressure traits where full GWAS results were available from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium, we estimated the trait correlations and applied the simulation approach to examine genomic regions with statistical evidence of pleiotropy. We then applied the approximation approach to explore GWAS summarized in the National Human Genome Research Institute (NHGRI) GWAS Catalog.
Results: By simulation, we identified pleiotropic regions including SH2B3 and BRAP (12q24.12) for hematologic and blood pressure traits. By approximation, we confirmed the genome-wide significant pleiotropy of these two regions based on the GWAS Catalog data, together with an exploration on other regions which highlights the FTO, GCKR and ABO regions.
Availability and Implementation: The Perl and R scripts are available at http://www.framinghamheartstudy.org/research/gwas_pleiotropictool.html.
Contact: odonnellc@nhlbi.nih.gov
Supplementary information: Supplementary data are available at Bioinformatics online.
TEQC: an R package for quality control in target capture experiments
Authors: Hummel Manuela , Bonnin Sarah , Lowy Ernesto , Roma Guglielmo 
Published: March 2011

Abstract
Summary: TEQC is an R/Bioconductor package for quality assessment of target enrichment experiments. Quality measures comprise specificity and sensitivity of the capture, enrichment, per-target read coverage and its relation to hybridization probe characteristics, coverage uniformity and reproducibility, and read duplicate analysis. Several diagnostic plots allow visual inspection of the data quality.
Availability and implementation: TEQC is implemented in the R language (version &gt;2.12.0) and is available as a Bioconductor package for Linux, Windows and MacOS from www.bioconductor.org.
Contact: manuela.hummel@crg.es
Integral business transformation: a global case study
Authors: Pérez la Rotta Alberto , Campos Herrera Laura 
Published: March 2011

PurposeThe purpose of this paper is to share an integral business transformation approach and to illustrate its application in a real case in the pharmaceutical industry.Design/methodology/approachThis model has been inspired and developed after years of research, successfully working with different leading organizations in Latin America. Its main pillars are the identification of new rules of success and the awareness of the transformation implications. It links the strategy, the people, and the processes as a system in a new way which will respond better to the challenging and changing conditions of the environment. It allows for the creation of new relationships inside and outside the organization. This facilitates employee/customer engagement, results, and fulfillment as the basis for business sustainability.FindingsResults indicate that the identification of new rules of success and the re‐articulation of the system implies a transformation of the individuals as well as the organization in a connected way. The capability to do this generates business results.Practical implicationsLeaders must be aware of the implications in their role as context creators in which customer and employee emotional engagement occurs. Leaders also need to rearticulate the human and business system to discover and implement new rules of success as the key success factors for growth.Originality/valueThis is the first time, according to the authors, there is sharing of the application of an integrated approach linking business and emotional issues which lead to performance and fulfillment.
The Genos employee motivation assessment
Authors: Gignac Gilles E. , Palmer Benjamin R. 
Published: March 2011

PurposeThis paper aims to describe a new measure of employee motivational fit, namely the Genos employee motivation assessment (GEMA), its predictive validity and use in learning and organizational development activities.Design/methodology/approachWithin three different organizations, employees completed GEMA via an online web survey system. Correlation analyses were then performed with a series of job performance and employee engagement data.FindingsMotivational fit (i.e. the degree of alignment between what an individual is motivated by and experiences in their work), within four areas measured by GEMA (namely, role fit, management fit, team fit, and organization fit), were found to be associated with average predictive validity correlation coefficients equal to 0.46, .073, 0.67, and 0.52, respectively.Research limitations/implicationsStatistical analyses at the individual level would be beneficial in future research. Additionally, whether motivational fit can be improved via learning and/or organizational development interventions, and whether such improvement leads to corresponding improvements in performance and engagement remains to be determined.Practical implicationsIntervention initiatives designed to improve motivational fit need to be designed and tested. The findings of this study suggest that successful interventions may result in improvements in job performance and employee engagement.Originality/valueThis paper will be of interest to professionals in recruitment, learning and organizational development interested in the improvement of job performance and employee engagement. This is the first study to examine the validity of GEMA scores and to propose the potential use of motivational fit as an intervention medium to improve these areas.