bluuebunny/crossref_metadata_2025_split huggingface dataset:
Do MRI features distinguish Wilson's disease from other early onset extrapyramidal disorders? An analysis of 100 cases
Authors: Prashanth L.K. , Sinha S. , Taly A.B. , Vasudev M.K. 
Published: March 2010

AbstractMagnetic resonance imaging (MRI) is frequently used in the evaluation of various extrapyramidal disorders. Among the plethora of MRI features in Wilson's disease (WD), only “face of the giant panda” sign has been recognized to distinguish WD from other early onset extrapyramidal disorders (EOEPD). To ascertain the value of various MRI features in differentiating neuropsychiatric form of WD from other EOEPD. This retrospective analysis included 100 patients (M:F = 56:44) of EOEPD (5–40 years), who had undergone MRI during Jan'03 to Nov'08. Their clinical features were recorded and the following MR sequences were analyzed: T1WI, T2WI, FLAIR. Fifty‐six patients had WD (M:F = 28:30, age at onset: 14 ± 6.8 years) and 44 had other EOEPD (M:F = 27:17, age at onset: 19 ± 9.8 years) that included Huntington's disease‐4, young‐onset Parkinson's disease‐7, mitochondrial disorders‐2, Hallervorden‐Spatz disease‐8, non‐Wilsonian hepatolenticular degeneration‐2, toxic/metabolic disorder‐1, and others‐20. The duration of illness at the time of MRI was comparable (WD: 3.1 ± 4.9 years; Other EOEPD: 2.8 ± 2.4 years). MR signal characteristics varied in topography and severity in both the groups. All the patients of WD had signal abnormalities in MRI, as against 16/44 of the other EOEPD group. The following MR observations were noted exclusively in WD: “Face of giant panda” sign (14.3%), tectal plate hyperintensity (75%), central pontine myelinolysis (CPM)‐like abnormalities (62.5%), and concurrent signal changes in basal ganglia, thalamus, and brainstem (55.3%). Besides “Face of giant panda” sign, hyperintensities in tectal‐plate and central pons (CPM‐like), and simultaneous involvement of basal ganglia, thalamus, and brainstem are virtually pathognomonic of WD. © 2010 Movement Disorder Society
Imaging essential tremor
Authors: Isaias Ioannis U. , Marotta Giorgio , Hirano Shigeki , Canesi Margherita , Benti Riccardo , Righini Andrea , Tang Chengke , Cilia Roberto , Pezzoli Gianni , Eidelberg David , Antonini Angelo 
Published: March 2010

AbstractTo investigate over time changes in striatal dopamine transporter (DAT), we performed two sequential N‐ω‐fluoropropyl‐2β‐carbomethoxy‐3β‐(4‐iodophenyl) tropane single photon computed tomography (SPECT) scans in 20 subjects with essential tremor (ET), in 13 with Parkinson disease (PD) and in 23 healthy controls (HC, one scan only). We also performed an [99mTc]ethyl cysteinate dimer bicisate SPECT exam for regional brain network analysis in 9 ET, in a second group of 18 PD (9 with tremor, tPD and 9 akinetic‐rigid dominant, arPD) and in 8 HC. PD subjects had a reduced DAT binding in comparison to ET and HC with an annual decline rate of 7.3% in the contralateral putamen. There were no mean uptake differences between ET and HC at baseline and no uptake loss over time in ET. A discriminant analysis grouped 30% (first scan) and 5% (second scan) of ET as PD and a partition analysis showed overlap between ET and PD for caudate nucleus uptake. Spatial covariance analysis revealed that the expression of the PD‐related regional pattern separated both tPD and arPD from ET and HC. In conclusion, PD and ET do not share a common pattern of dopaminergic loss over time. However, mild impairment of dopamine transporter in the caudate nucleus may contribute to tremor onset in ET. © 2010 Movement Disorder Society
Movement disorders and pregnancy: A review of the literature
Authors: Kranick Sarah M. , Mowry Ellen M. , Colcher Amy , Horn Stacy , Golbe Lawrence I. 
Published: March 2010

AbstractPregnant patients are rarely encountered in the movement disorders clinic, but they present significant dilemmas regarding treatment and counseling for neurologists. While movement disorders in pregnancy once described those disorders arising de novo during pregnancy, such as chorea gravidarum or restless leg syndrome, advancing maternal age in Western countries will likely increase the number of women in whom pregnancy complicates a pre‐existing movement disorder. Physicians treating these women must be aware of the impact of the movement disorder and its treatment on fertility, pregnancy, fetal development, lactation, and infant care. This review summarizes retrospective series and case reports to both guide clinicians and to stimulate and direct the design of prospective studies. © 2010 Movement Disorder Society
Increased 5‐HT2Areceptors in the temporal cortex of parkinsonian patients with visual hallucinations
Authors: Huot Philippe , Johnston Tom H. , Darr Tayyeba , Hazrati Lili‐Naz , Visanji Naomi P. , Pires Donna , Brotchie Jonathan M. , Fox Susan H. 
Published: March 2010

AbstractWell‐formed visual hallucinations (VH) are common in patients with Parkinson's disease (PD). The pathophysiology of VH in PD is unknown but may involve structures mediating visual processing such as the inferior temporal cortex. Serotonergic type 2A (5‐HT2A) receptors have been linked to many psychiatric disorders, including psychosis. We hypothesized that enhanced 5‐HT2Areceptor levels may be involved in VH in PD. Autoradiographic binding using [3H]‐ketanserin and spiperone, to define 5‐HT2Areceptors, was performed in 6 PD patients with VH, 6 PD patients without VH, and 5 healthy, age‐matched controls. The cerebral regions studied included the orbitofrontal cortex, inferolateral temporal cortex, motor cortex, striatum, and substantia nigra. There was a significant (45.6%) increase in the levels of [3H]‐ketanserin binding in the inferolateral temporal cortex of PD patients with VH when compared with PD patients without VH (54.3 ± 5.2 fmol/mg vs. 37.3 ± 4.3 fmol/mg,P= 0.039). Additionally, there was a significant increase in the levels of 5‐HT2Areceptors in the motor cortex of all PD patients taken as a group when compared with controls (57.8 ± 5.7 fmol/mg vs. 41.2 ± 2.6 fmol/mg,P= 0.0297). These results suggest that enhanced 5‐HT2A‐mediated neurotransmission in the inferolateral temporal cortex, a critical structure in visual processing, might be associated with the development of VH in PD. Our results provide new insights into the pathophysiology of VH in PD and provide an anatomical basis to explain why compounds with 5‐HT2Aantagonist activity are effective at alleviating this debilitating complication. © 2010 Movement Disorder Society
Types of lymphoscintigraphy and indications for lymphaticovenous anastomosis
Authors: Maegawa Jiro , Mikami Taro , Yamamoto Yasushi , Satake Toshihiko , Kobayashi Shinji 
Published: March 2010

AbstractSeveral authors have reported the usefulness and benefits of lymphoscintigraphy. However, it is insufficient to indicate microvascular treatment based on lymphedema. Here, we present the relationships between lymphoscintigraphic types and indications for lymphatic microsurgery. Preoperative lymphoscintigraphy was performed in 142 limbs with secondary lymphedema of the lower extremity. The images obtained were classified into five types. Type I: Visible inguinal lymph nodes, lymphatics along the saphenous vein and/or collateral lymphatics. Type II: Dermal backflow in the thigh and stasis of an isotopic material in the lymphatics. Type III: Dermal backflow in the thigh and leg. Type IV: Dermal backflow in the leg. Type V: Radiolabeled colloid remaining in the foot. Lymphaticovenous anastomosis was performed in 35 limbs. The average number of anastomoses per limb was 3.3 in type II, 4.4 in type III, 3.6 in type IV, and 3 in type V. The highest number of anastomosis was performed in type III. In conclusion, type III is suggested to be the best indication for anastomosis compared with types IV and V. © 2010 Wiley‐Liss, Inc. Microsurgery 30:437–442, 2010.
A case of intraoperative venous congestion of the entire DIEP‐flap—A novel salvage technique and review of the literature
Authors: Momeni Arash , Lee Gordon K. 
Published: March 2010

AbstractThe deep inferior epigastric perforator (DIEP) flap is gaining popularity for autologous breast reconstruction as it reportedly reduces abdominal donor site morbidity when compared with the transverse rectus abdominis musculocutaneous (TRAM) flap. Disadvantages include greater technical difficulties during flap harvest and a greater incidence of vascular compromise. A well‐known and feared complication is venous congestion which requires immediate intervention. We present a novel salvage technique in a case of total flap venous congestion in the setting of absent drainage via the deep inferior epigastric vein (DIEV). Utilizing the superficial venous system via the superficial inferior epigastric vein (SIEV) and using the DIEV as a venous interposition graft resulted in successful salvage of the DIEP flap. © 2010 Wiley‐Liss, Inc. Microsurgery 30:443–446, 2010.
Novel Approach for Clustering Zeolite Crystal Structures
Authors: Lach‐hab M. , Yang S. , Vaisman I. I. , Blaisten‐Barojas E. 
Published: March 2010

AbstractInformatics approaches play an increasingly important role in the design of new materials. In this work we apply unsupervised statistical learning for identifying four framework‐type attractors of zeolite crystals in which several of the zeolite framework types are grouped together. Zeolites belonging to these super‐classes manifest important topological, chemical and physical similarities. The zeolites form clusters located around four core framework types: LTA, FAU, MFI and the combination of EDI, HEU, LTL and LAU. Clustering is performed in a 9‐dimensional space of attributes that reflect topological, chemical and physical properties for each individual zeolite crystalline structure. The implemented machine learning approach relies on hierarchical top‐down clustering approach and the expectation maximization method. The model is trained and tested on ten partially independent data sets from the FIZ/NIST Inorganic Crystal Structure Database
Structural correlations for 1H, 13C and 15N NMR coordination shifts in Au(III), Pd(II) and Pt(II) chloride complexes with lutidines and collidine
Authors: Pazderski Leszek , Pawlak Tomasz , Sitkowski Jerzy , Kozerski Lech , Szłyk Edward 
Published: March 2010

Abstract1H, 13C and 15N NMR studies of gold(III), palladium(II) and platinum(II) chloride complexes with dimethylpyridines (lutidines: 2,3‐lutidine, 2,3lut; 2,4‐lutidine, 2,4lut; 3,5‐lutidine, 3,5lut; 2,6‐lutidine, 2,6lut) and 2,4,6‐trimethylpyridine (2,4,6‐collidine, 2,4,6col) having general formulae [AuLCl3], trans‐[PdL2Cl2] and trans‐/cis‐[PtL2Cl2] were performed and the respective chemical shifts (δ1H, δ13C, δ15N) reported. The deshielding of protons and carbons, as well as the shielding of nitrogens was observed. The 1H, 13C and 15N NMR coordination shifts (Δ1Hcoord, Δ13Ccoord, Δ15Ncoord; Δcoord = δcomplex − δligand) were discussed in relation to some structural features of the title complexes, such as the type of the central atom [Au(III), Pd(II), Pt(II)], geometry (trans‐ or cis‐), metal‐nitrogen bond lengths and the position of both methyl groups in the pyridine ring system. Copyright © 2010 John Wiley & Sons, Ltd.
Synthesis and NMR elucidation of novel pentacycloundecane‐based peptides
Authors: Altaib Mohamed S. , Arvidsson Per I. , Govender Thavendran , Maguire Glenn E. M. , Makatini Maya , Onajole Oluseye K. , Kruger Hendrik G. 
Published: March 2010

AbstractThe synthesis and NMR elucidation of two novel pentacycloundecane (PCU)‐based peptides are reported. The PCU cage amino acids were synthesised as racemates and the incorporation of the cage amino acid with (S)‐natural amino acids produced diastereomeric peptides. The diastereomeric ‘cage’ peptides were separated using preparative HPLC and the NMR elucidation of these PCU containing peptides are reported for the first time. The 1H and 13C NMR spectra showed series of overlapping signals of the cage skeleton and that of the peptide, making it extremely difficult to resolve the structure using one‐dimensional NMR techniques only. The use of two‐dimensional NMR techniques proved to be a highly effective tool in overcoming this problem. Copyright © 2010 John Wiley & Sons, Ltd.
Assignment and conformational investigation of asymmetric phenylindenylidene ruthenium complexes bearing N,O‐bidentate ligands
Authors: Hendrickx P. M. S. , Drozdzak R. , Verpoort F. , Martins J. C. 
Published: March 2010

AbstractThe NMR conformational study of three asymmetric phenylindenylidene ruthenium complexes 4.1–4.3, is presented. Complete 1H and 13C assignments could be obtained for 4.1–4.3 in benzene solution from multiple 2D homonuclear and heteronuclear NMR techniques. Our NMR analysis shows that each complex exists as a 55:45 mixture of two rotational isomers in slow exchange on the NMR chemical shift timescale. They are shown to be related by a 180° flip of the indenylidene ligand along the RuCR bond. Both rotational isomers can be discriminated by means of NOEs contacts between the various ligands coordinating to the Ru. By matching these stereospecific assignments to the chemical shift, a chemical shift based fingerprint of the isomers that may allow straightforward assignment of future asymmetric phenylindenylidene ruthenium complexes is proposed. Copyright © 2010 John Wiley & Sons, Ltd.
Localized electrical current propagation in anisotropically perturbed atmospheres
Authors: Zohdi T. I. 
Published: March 2010

AbstractThe trajectory of free atmospheric electrical currents, such as lightning and sparks, is strongly influenced by microscale events that occur at the current front. In particular, highly conductive pathways can occur at the free surface front due to dielectric breakdown. The specific directions of the local pathways are minutely perturbed, due to the gaseous, disordered, nature of the media at the small scale. This results in highly conductive, anisotropically perturbed, continuum‐level properties at the electrical current front. In this work, a model is developed to investigate the role of the resulting anisotropically perturbed conductivity at the propagation front on the overall trajectory of free atmospheric electrical currents. The approach is to relate the electrical current velocity to the local anisotropic conductivity at the propagation front and the surrounding electric field. The conductive anisotropy is decomposed into an isotropic ‘base state’ and an anisotropic perturbation. The current trajectory is shown to be governed by a set of non‐linear differential equations, for which a numerical solution scheme is developed. The difference between paths taken through anisotropically perturbed and isotropic media is analytically bounded and quantified numerically as a function of the magnitude of the anisotropic perturbation. The analysis and numerical experiments indicate that, in a statistical sense, the difference in the paths taken in anisotropically perturbed and isotropic media depends quasilinearly on the perturbation magnitude. Copyright © 2010 John Wiley & Sons, Ltd.
Linear viscoelasticity, probe tack, and extrusion flow results of SEBS copolymers
Authors: Arevalillo Alfonso , Fernández Mercedes , Muñoz María Eugenia , Santamaría Anton 
Published: March 2010

AbstractMicrophase‐separated poly(styrene‐b‐ethylene‐co‐butylene‐ b‐styrene) copolymers of different molecular weights with polystyrene (PS) volume fraction ϕ = 0.30 are investigated. Linear dynamic viscoelastic data reveal the blocking effect of the ordered PS microdomains, which produces a predominantly elastic response at low frequencies, associated with a mechanical relaxation. These results are correlated with tack and extrusion flow measurements, which involve polymer/metal adhesion processes. Nonlinearity implied in some experiments alters the ordered morphology of low molecular weight samples producing a viscous dominant behavior. Dissipation is reflected in viscous‐like adhesion and lack of viscoplastic response in extrusion flow experiments. For the highest molecular sample, only a rubbery or entangled state (G′ > G″ and G′ > 105 Pa) is observed in the linear viscoleastic regime. This is associated with the lack of adhesion seen in both, probe tack experiments and capillary flow measurements. This lack of adhesion gives rise to a plug‐flow as the polymer slips in the capillary wall. POLYM. ENG. SCI., 2010. © 2010 Society of Plastics Engineers
Prediction of glass transition temperatures of aromatic heterocyclic polyimides using an ANN model
Authors: Liu Wanqiang 
Published: March 2010

AbstractAromatic heterocyclic polyimides are used extensively in industries for their excellent mechanical properties, high glass transition temperatures (Tg), and so on. A quantitative structure–property relationship (QSPR) model was developed to predict the Tg values with 54 aromatic heterocyclic polyimides by using an artificial neural network (ANN) back‐propagation algorithm. Fifty‐four aromatic heterocyclic polyimides were randomly divided into a training set (36) and a test set (18). Three molecular descriptors (the connectivity index X1A, the topological descriptor PW3, and the 3D‐MoRSE descriptor Mor09e) were selected to produce the mode. Simulated with the final optimum ANN model with 3‐3‐1 structure, the results show that the predicted Tg values are in good agreement with the experimental ones, with the root mean square errors (RMSEs) of 12.4 K (R = 0.935) and 16.4 K (R = 0.937) for the training set and the test set, respectively. POLYM. ENG. SCI., 50:1547–1557, 2010. © 2010 Society of Plastics Engineers
Quantitative milk proteomics – Host responses to lipopolysaccharide‐mediated inflammation of bovine mammary gland
Authors: Danielsen Marianne , Codrea Marius C. , Ingvartsen Klaus L. , Friggens Nicolas C. , Bendixen Emøke , Røntved Christine M. 
Published: March 2010

AbstractIntramammary infusion of lipopolysaccharide (LPS) in cows induces udder inflammation that partly simulates mastitis caused by infection with Gram‐negative bacteria. We have used this animal model to characterize the quantitiative response in the milk proteome during the time course before and immediately after the LPS challenge. Milk samples from three healthy cows collected 3 h before the LPS challenge were compared with milk samples collected 4 and 7 h after the LPS challenge, making it possible to describe the inflammatory response of individual cows. Quantitative protein profiles were obtained for 80 milk proteins, of which 49 profiles changed significantly for the three cows during LPS challenge. New information obtained in this study includes the quantified increase of apolipoproteins and other anti‐inflammatory proteins in milk, which are important for the cow's ability to balance the immune response, and the upregulation of both complement C3 and C4 indicates that more than one complement pathway could be activated during LPS‐induced mastitis. In the future, this analytical approach may provide valuable information about the differences in the ability of individual cows to resist and recover from mastitis.
Unbearable suffering of patients with a request for euthanasia or physician‐assisted suicide: an integrative review
Authors: Dees Marianne , Vernooij‐Dassen Myrra , Dekkers Wim , van Weel Chris 
Published: March 2010

AbstractPurpose: In the legal performance of the euthanasia procedure, unbearable suffering, one of the requirements of due care, is difficult to assess. Evaluation of the current knowledge of unbearable suffering is needed in the ongoing debate about the conditions on which EAS can be approved.Methods: Using an integrative literature review, we evaluated publications with definitions of suffering in general or in end‐of‐life situations and with descriptions of suffering in the context of a request for EAS.Data synthesis: From the 1482 citations identified, we included 55 publications: 20 articles about definitions of suffering and 35 empirical studies on suffering. We found no definition of unbearable suffering in the context of a request for EAS. Qualitative patient‐centered studies revealed the most motivations, and the most motivations named by only one of the three parties involved. The studies of relatives were limited, mainly quantitative and retrospective. We found no studies that brought together the views of the patients, relatives, and healthcare professionals.Conclusions: There is no generally accepted definition of ‘unbearable suffering’ in the context of a request for EAS. On the basis of the articles reviewed, we propose the following conceptual definition: ‘Unbearable suffering in the context of a request for EAS is a profoundly personal experience of an actual or perceived impending threat to the integrity or life of the person, which has a significant duration and a central place in the person's mind’. Further patient‐centered qualitative research into suffering is needed to clarify this definition. Copyright © 2009 John Wiley & Sons, Ltd.
Crystal structure of the crenarchaeal conserved chromatin protein Cren7 and double‐stranded DNA complex
Authors: Feng Yingang , Yao Hongwei , Wang Jinfeng 
Published: March 2010

AbstractCren7 is a crenarchaeal conserved chromatin protein discovered recently. To explore the mechanism of the DNA packaging in Crenarchaeota, the crystal structure of Cren7–GCGATCGC complex has been determined and refined at 1.6 Å resolution. Cren7 kinks the dsDNA sharply similar to Sul7d, another chromatin protein existing only in Sulfolobales, which reveals that the “bending and unwinding” compacting mechanism is conserved in Crenarchaeota. Significant structural differences are revealed by comparing both protein–dsDNA complexes. The kinked sites on the same dsDNA in the complexes with Sul7d and Cren7 show one base pair shift. For Cren7, fewer charged residues in the β‐barrel structural region bind to DNA, and additionally, the flexible loop Lβ3β4 is also involved in the binding. Electrophoretic mobility shift assays indicate that loop Lβ3β4 is essential for DNA‐binding of Cren7. These differences provide insight into the functional difference of both chromatin proteins, suggesting that Cren7 may be more regulative than Sul7d in the DNA‐binding affinity by the methylation in the flexible loop Lβ3β4
in vivo.
Solution structure of the N‐terminal domain of DC‐UbP/UBTD2 and its interaction with ubiquitin
Authors: Song Ai‐Xin , Zhou Chen‐Jie , Guan Xiao , Sze Kong‐Hung , Hu Hong‐Yu 
Published: March 2010

AbstractDC‐UbP/UBTD2 is a ubiquitin (Ub) domain‐containing protein first identified from dendritic cells, and is implicated in ubiquitination pathway. The solution structure and backbone dynamics of the C‐terminal Ub‐like (UbL) domain were elucidated in our previous work. To further understand the biological function of DC‐UbP, we then solved the solution structure of the N‐terminal domain of DC‐UbP (DC‐UbP_N) and studied its Ub binding properties by NMR techniques. The results show that DC‐UbP_N holds a novel structural fold and acts as a Ub‐binding domain (UBD) but with low affinity. This implies that the DC‐UbP protein, composing of a combination of both UbL and UBD domains, might play an important role in regulating protein ubiquitination and delivery of ubiquitinated substrates in eukaryotic cells.
Direct identification of the site of binding on the chaperone SecB for the amino terminus of the translocon motor SecA
Authors: Randall Linda L. , Henzl Michael T. 
Published: March 2010

AbstractProtein export mediated by the general secretory Sec system in Escherichia coli proceeds by a dynamic transfer of a precursor polypeptide from the chaperone SecB to the SecA ATPase motor of the translocon and subsequently into and through the channel of the membrane‐embedded SecYEG heterotrimer. The complex between SecA and SecB is stabilized by several separate sites of contact. Here we have demonstrated directly an interaction between the N‐terminal residues 2 through 11 of SecA and the C‐terminal 13 residues of SecB by isothermal titration calorimetry and analytical sedimentation velocity centrifugation. We discuss the unusual binding properties of SecA and SecB in context of a model for transfer of the precursor along the pathway of export.