bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pulmonary Function and Bronchopulmonary Dysplasia Classification: Insights from the Spanish Registry
Authors: Ramos-Navarro Cristina , Sánchez-Luna Manuel , Pérez-Tarazona Santiago , Sanz-López Ester , Maderuelo-Rodriguez Elena , Rueda-Esteban Santiago , Sánchez-Torres Ana , Concheiro-Guisán Ana , Sánchez-Solís Manuel , Network GEIDIS Research 
Published: April 2024

Abstract

Background and Aims
In 2016, the Spanish Research Group on Bronchopulmonary Dysplasia (BPD) (GEIDIS) established a national registry with participation of 66 hospitals to collect information on clinical characteristics and long-term outcomes of BPD infants into adulthood. The aim of this study is to examine forced spirometry data in early childhood and to assess their correlation with the respiratory support required at 36 weeks postmenstrual age (PMA).
Methods
The study analyzed data from preterm infants with BPD born between January 2016 and December 2017 who underwent forced spirometry at 5-7 years of age.
Statistical analyses were conducted to investigate the relationships between spirometry results, perinatal factors, and the required respiratory support at 36 weeks PMA.
Results
The study involved 143 patients with a median gestational age (GA) of 27.3 weeks (range: 25.7-28.7) and a median weight of 880 grams (range: 740-1135). Pathological spirometry was observed in 39.2% (56) of the patients.
Among patients diagnosed with BPD type 3, those requiring over 30% oxygen at 36 weeks PMA exhibited an increased risk of pathological spirometry (OR 4.48; 95% CI: 1.11-18.13) compared to those requiring positive pressure with less than 30% oxygen. In addition, this subgroup had a higher risk of developing a restrictive-mixed pattern compared to those with BPD type 1 (OR 10,65; 95% IC 2,06-54,98) and BPD type 2 (OR 6,76; 95% IC 1,09-42,06). No significant differences were found in the incidence of an obstructive pattern between BPD types. Additionally, the study revealed distinct etiopathogenic mechanisms underlying the development of restrictive versus obstructive patterns.
Conclusions:
The requirement of more than 30% oxygen at 36 weeks PMA serves as a risk indicator for pulmonary function impairment in school-aged children with BPD. These findings suggest persistent airway and parenchymal injury in this specific patient population, and highlight the importance of careful monitoring to evaluate their long-term effects on lung function.
An Adrenal Mass After Colorectal Carcinoma, Is It a Primer Lesion, a Metastasis or Nothing? A Case Report
Authors: DAŞ Adalet , CAKCAK İbrahim Ethem , KARABULUT Derya , TÜRK Dicle TAMER 
Published: April 2024

Abstract

INTRODUCTION: Liver is the most frequent metastatic site of colorectal carcinoma. Adrenal metastasis is the second most common reason of “adrenal incidentaloma”. The presence of solitaire adrenal metastasis from colorectal carcinoma (CRC) is unusual but adrenal metastasis from CRC is not an uncommon event.
CASE PRESENTATION: We present 60-year-old man who has a history of colorectal cancer with a suspicion of solitary adrenal metastasis from colorectal carcinoma. The patient underwent open adrenalectomy after radiological examinations’ and laboratory tests’ compatible results. Histopathological examination showed inflammatory cells with hemorrhage and necrosis.
CONCLUSION: We made a literature analysis regarding the accuracy of imaging evaluations and laboratory tests. It is seen that radiological examinations and laboratory test results do not always comply with the post-op results. Differential diagnosis and different diagnostic procedures should be considered.
Assessment of Rhizopus arrhizus RL (OR398886) chitosan-based films as a sustainable option for fresh beef packaging
Authors: Mahmoud Mohamed A. A. , Yehyei Samah M. , Oraby Mona M. , Abou-Taleb Khadiga A. A. , Amin Shimaa A. , Abou-Taleb Kh. A.A. 
Published: April 2024

Abstract

Meat spoilage is a significant concern in the food industry, prompting the need for effective preservation methods to prolong shelf life and maintain product quality. This study aimed to investigate the effects of fungal-based chitosan films at different concentration levels (5%, 10%, 15%, and 20%) on the sensory, chemical, and microbiological characteristics of beef meat stored at 4°C ± 1 for 12 days. The results showed that the Rhizopus arrhizus RL (OR398886) chitosan-based films, especially at higher concentrations, improved the moisture retention, lipid preservation, and sensory attributes of the meat samples. Moreover, these films exhibited notable antimicrobial properties against bacteria, yeast, and fungi. The survival test and the chemometric analysis confirmed that the samples wrapped in 15% and 20% fungal chitosan-based films maintained the highest acceptability and quality for 12 days, therefore demonstrating their potential as an effective strategy for extending the shelf-life and enhancing the quality of meat products.
China's Revitalized Primary Care and Its Impact on Triple Aims for Chronic Diseases Patients: A Retrospective Cohort Study
Authors: Wang Yang , Chu Hongling , Yang Hui , Jin Hua , Zou Chuan , Fang Hai 
Published: April 2024

Abstract

Objective To evaluate the effectiveness, patient experience, and cost-efficiency of primary care versus hospital care for middle-aged and elderly patients with chronic diseases in China, in the context of achieving the triple aim of healthcare: improving population health, reducing per capita costs, and enhancing patient satisfaction.Methods A longitudinal cohort analysis using data from the China Health and Retirement Longitudinal Study (CHARLS) spanning the years 2011, 2013, 2015, and 2018.The study included participants aged 45 and older from 450 communities across mainland China, specifically targeting those with chronic diseases. Individuals without chronic conditions or with incomplete data were excluded.Results The analysis encompassed 50,800 subjects. Those who visited hospitals for outpatient treatment—mainly urban residents with higher education and income levels, and with comprehensive insurance coverage—demonstrated poorer health outcomes (OR = 1.06, 95%CI 1.02–1.10, p = 0.002) and higher medical expenses (OR = 1.99, 95% CI 1.93–2.06, p < 0.001) compared to those who utilized primary care facilities. No significant difference was observed in satisfaction levels between the two groups (OR = 0.99, 95% CI 0.92–1.07, p = 0.85).Conclusions This study indicates that for patients over 45 with chronic diseases, China's primary care can achieve health outcomes comparable to or better than large hospitals, at significantly lower costs. Despite some data limitations, it highlights the effectiveness of primary care in improving health for socioeconomically disadvantaged groups, advocating for more government investment and policy support to enhance primary care's affordability and functionality.
Comparison of Machine Learning Methods for Predicting 3-Year Survival in Elderly Esophageal squamous cancer Patients Based on Oxidative Stress
Authors: Xie Jin-Biao , Huang Shi-Jie , Gao Lei , Yang Tian-Bao , Wang Wu , Chen Bo-Yang 
Published: April 2024

Abstract

Background There is currently a lack of machine learning model studies exploring the relationship between oxidative stress score (OSS) and the prognosis of elderly Esophageal squamous cancer(ESCC) patients.
MethodsThis study included elderly ESCC patients who underwent curative resection surgery from January 2013 to December 2020. Machine learning strategies including decision tree (DT), random forest (RF), and support vector machine (SVM) were employed to construct a predictive model for 3-year overall survival (OS) for elder ESCC base on OSS.
ResultsPatients were divided into derivation cohort and validation cohort, and consisted of 340 and 145 patients, respectively. 8 important features which were the most important factors influencing 3-year OS (pathological N stage, pathological T stage, tumor histological type, vascular invasion, CEA, OSS, CA 19-9, and the amount of bleeding) were included in training the RF, DT and SVM. In the derivation cohort, the RF model exhibited the highest predictive performance with an AUC of 0.975(0.962-0.987), while the DT model is 0.784(0.739-0.830) and the SVM is 0.879(0.843-0.916). In the external validation cohort showed the similar trend .
Conclusion The random forest clinical prediction model constructed based on OSS can effectively predict the prognosis of elderly ESCC patients after curative surgery.
Detection of clinically significant prostate cancer following initial omission of biopsy in multiparametric MRI era
Authors: Li Eric , Busza Anna , Siddiqui Mohammad , Aguiar Jonathan , Keeter Mary-Kate , Neill Clayton , Kumar Sai , Mi Xinlei , Schaeffer Edward , Patel Hiten , Ross Ashley 
Published: April 2024

Abstract

Background Multiparametric prostate MRI (mpMRI) is being increasingly adopted for work-up of prostate cancer. For patients selected to omit biopsy, we identified factors associated with repeat MRI, eventual prostate biopsy, and subsequent detection of clinically significant prostate cancer (csPCa, Grade Group ≥ 2).Methods We identified biopsy-naïve men presenting with PSA 2–20 ng/mL (March 2018-June 2021) undergoing initial mpMRI with PIRADS 1–3 lesions who were not selected for biopsy with ≥ 6 months follow-up. We examined factors associated with repeat mpMRI, progression to biopsy, and subsequent detection of csPCa with univariable and multivariable logistic regression.Results Of 1494 men, 31% (463/1494) did not pursue biopsy. PSA density (PSAD) ≤ 0.1, prostate health index (PHI) < 55, and PIRADS 1–2 were associated with omission of prostate biopsy. csPCa diagnosis-free survival was 97.6% (326/334) with median follow up of 23.1 months (IQR 15.1–34.6 months). Black race, PSA, PHI, PSA density, and PSA and PHI velocity were significant predictors of undergoing repeat mpMRI (15.6%, 52/334) and subsequent biopsy (8.4%, 28/334). 8 men were subsequently diagnosed with csPCa (N = 7 on prostate biopsy; N = 1 incidentally on holmium enucleation of prostate). All patients diagnosed with csPCa had PIRADS 4–5 on repeat mpMRI.Conclusions The subsequent detection rate of csPCa among patients not initially biopsied after mpMRI was low at 2.4%. Decisions to omit biopsy after reassuring PHI and mpMRI appear safe.
CT radiomics for Predicting Survival in Patients with Unresectable Pancreatic Ductal Adenocarcinoma after Chemotherapy
Authors: Zhu Yong , Cui Wenjing , Jin Hailin , Wang Jianhua , Wang Zhongqiu 
Published: April 2024

Abstract

Objective: To investigate the ability of preoperative CT-based radiomics signature to be used as prognostic indicators of unresectable pancreatic ductal adenocarcinoma (PDAC) after chemotherapy and develop radiomics-based prediction models.
Methods: Clinicopathological data and radiomics features of 146 pancreatic cancer patients (102 in the training cohort and 44 in the testing cohort) were retrospectively reviewed. Radiomics features were selected by the lasso cox regression model. Multivariate Cox regression analysis was used to establish the radiomics model, clinicopathologic model, and combined model in the training cohort to predict survival of PDAC after chemotherapy, and then verified in the testing cohort.
Results: Of 855 extracted radiomics features in portal venous CT images, 15 most stable features were selected. Multivariate Cox regression analysis identified radiomics model riskscore, diabetes, common hepatic artery invasion, and splenic vein invasion to construct a combined model for predicting overall survival (OS) of unresectable PDAC (with AUC of 0.949 in the validation set; 95% CI 0.889-1.000). While the AUC of the radiomics model and clinicopathologic model were 0.901 (95% CI, 0.812-0.990) and 0.556 (95% CI, 0.382-0.730), respectively.
Conclusion: CT radiomics signature is a powerful predictor associated with OS in patients with unresectable PDAC after chemotherapy. The combined model performed well in predicting survival.
Correlation of non-auditory comorbidities and hearing loss in tinnitus patients
Authors: Tziridis Konstantin , Neubert Benjamin , Seehaus Anna , Krauss Patrick , Schilling Achim , Brüggemann Petra , Mazurek Birgit , Schulze Holger 
Published: April 2024

Abstract

Tinnitus is a symptom often associated with hearing loss (HL) and is in many cases more burdening to the individual than the HL itself. Many approaches have been made to explain the development and chronification of the phantom percept as well as different treatment strategies to lower the tinnitus related burden. In many studies, the variance of the HL data is high and therefore the interpretation of specific data might be difficult. With this retrospective study, we attempt to explain a part of this variance by investigating specifically the effects of non-auditory comorbidity categories on pure-tone audiometric data in a tinnitus patient collective that was homogeneous with respect to auditory comorbidities. We found age dependent as well as number of non-auditory comorbidity (e.g. diabetes mellitus) dependent differences in the mean HL of the tinnitus patients as well as differences in the peak HL frequency relative to the tinnitus frequency. The analysis of the age dependent HL within the different non-auditory comorbidities revealed specific – partially opposed – effects of endocrine, circulatory, muscle-skeletal and digestive disease categories on the hearing thresholds of tinnitus patients. Taken together we argue that in future tinnitus (and non-tinnitus) patient studies also non-auditory comorbidities should be taken into account as possible covariables that might explain the variance found in the auditory threshold development of these patients.
Multi-objective grey correlation analysis based on CFRP helical milling simulation model
Authors: Zhou Lan , Wang Yunlong , An Guosheng , Zhu Ruibiao , Li Guangqi , Ma Rong 
Published: April 2024

Abstract

Helical milling is widely used in aerospace as a key processing technology for Carbon fiber reinforced polymer (CFRP). However, the eccentric machining characteristics lead to an unusually complex pattern of cutting force and residual stress distribution on the work-piece during helical milling processing. Based on the Hashin failure criterion, a 3D FEM model of CFRP helical milling was built for analyzing the changing law of cutting force, then the three factors and three levels orthogonal tests were used to investigate the influence of machining parameters on axial force, radial force and minimum principal residual stress, finally the multi-objective optimization based on grey correlation analysis was realized. Results showed that the errors of axial force and radial force obtained by simulation and experiment were 10.68% and 12.26%, respectively. The axial force and radial force were negatively correlated to the spindle speed, positively correlated to the axial cutting depth, and uncorrelated to the feed per tooth. The minimum principal residual stress was negatively correlated to the spindle speed, positively correlated to the feed per tooth, and uncorrelated to the axial cutting depth. The degree of influence on optimization of machining parameters was: spindle speed>axial cutting depth>feed per tooth. The corresponding average grey correlation degree differences were 0.280981, 0.216859 and 0.013422, respectively. The maximum value of grey correlation degree in the orthogonal test was 0.874372, and the corresponding optimal parameters combination was the spindle speed 8000 r/min, feed per tooth 0.03 mm/z and axial cutting depth 0.2 mm/r.
Neuropharmacological profile of Parawixin-11, purified from Parawixia bistriata spider venom (Araneae, Araneidae), in Wistar rats
Authors: Pereira Adriana Colsera , Cunha Alexandra Olimpio Siqueira , Mortari Márcia Renata , Fachim Helene Aparecida , Campos Gabriel Avohay Alves , Lopes Norberto Peporine , Santos Wagner Ferreira 
Published: April 2024

Abstract

The pharmacological treatment of epilepsy is often complex, involving lack of efficacy in several patients due to individual characteristics and profound side effects from current drugs such as sedation, motor impairment and teratogenesis. In the context of drug development for epilepsy, animal venoms represent an important source of new neuroactive molecules acting in different targets such as ion channels and neurotransmitter receptor. In this work we investigated the antiepileptic potential of compounds isolated from the venom of Parawixia bistriata spider. One compound, named here as Parawixin-11, revealed anticonvulsivant effect against seizures induced by bicuculline, pentylenetetrazole, strychnine, pilocarpine and NMDA in a dose-response manner. We also investigated whether the intracerebroventricular administration of Parawixin-11 induced significant motor or cognitive impairment in rats submitted to three tests: open field, rotarod and Morris water maze. No difference was observed on exploration or movement when animals were treated with either 0.3, 0.2 or 0.1 ug of Parawixin-11. An increased latency to find platform was observed in the acquisition phase of the Morris water maze test even though no difference in retention of spatial memory was observed. Considering that Parawixin-11 was more potent against NMDA induced crisis, we hypothesize that this molecule might be modulating the glutamatergic system, consistent with the mechanism of several spider polyamines.
Comparison of Remimazolam Versus Dexmedetomidine on the Quality of Recovery in Functional Endoscopic Sinus Surgery ： A Randomized Clinical Trial
Authors: Li Yaqiong , Gao Fanfan , Guan Qianqian , Zhou Hui , Wang Shengbin , Tan Yvqing , Hu Shenghong 
Published: April 2024

Abstract

Background: The quality of recovery (QoR) of remimazolam versus dexmedetomidine was compared as measured by QoR-40 scores in functional endoscopic sinus surgery (FESS).
Methods: 120 patients (18–65 years) scheduled for FESS were randomly allocated to the group R , group D or group C. Group R received remimazolam 0.075 mg/kg loading, 0.1mg/kg/h infusion.Group D received dexmedetomidine 1.0 µg/kg loading, 0.5 µg/kg/h infusion.Group C received the placebo equal to dexmedetomidine.The primary outcome was QoR-40 scores on the day before surgery and postoperative day 1 (POD1).Secondary outcomes were the time to awareness,the length of stay in the PACU,sedation score upon PACU arrival, pain, postoperative nausea and vomiting (PONV). Adverse effects were recorded.
Results: The total QoR-40 scores (median, IQR) on POD1 were decreased less(154.5, 152.0 to159.0) in the groups R and D (155.0, 154.8 to159.3)than in the group C (139.0, 136.8 to142.0) (P=0.000).The time to awareness and the length of stay in the PACU were significantly lower in the groups R and C than in the group D (P=0.000).The level of sedation upon PACU arrival (median, IQR) in the groups R (-2.0, -2.0 to -1.0) and D (-2.0, -3.0 to -2.0) was deeper than in the group C (1.0, 0.0 to 1.0)(P=0.000). Compared to the group C, the pain intensity was reduced inthe groups R and D (P=0.000). The incidence of PONV was lower in the groups R (6,15.0%) and D (8,20.0%) than in the group C (17,42.5%)(P=0.011).15 patients had bradycardia in the group D,while no bradycardia was noted in the groups R and C(P=0.000).
Conclusion: Administration of remimazolam could provided a similar QoR to dexmedetomidine. And remimazolam can be a promising option for improving the QoR in FESS.
Trial registration: ChiCTR2300076209. (Prospective registered). Initial registration date was 27/9/2023.
Meta-analysis on the entomological effects of differentially treated ITNs in a multi-site experimental hut study in sub-Saharan Africa
Authors: Lissenden Natalie , Bradley John , Menze Benjamin , Wondji Charles , Edi Constant , Koudou Benjamin , N’Guessan Raphael , Bayili Koama , Diabaté Abdoulaye , Mbewe Njelembo , Emidi Basiliana , Mosha Jacklin , Manjurano Alphaxard , Small Graham , Oumbouke Welbeck , Moore Sarah Jane , Nimmo Derric Nimmo , Snetselaar Janneke 
Published: April 2024

Abstract

Background:
Restricting the placement of active ingredients (AIs) to specific panels on insecticide-treated nets (ITNs) has the potential to reduce the amount of AI required to treat a net. If the restricted placement of the AIs can exploit mosquito behaviour, particularly where they interact with the bed net interface, and not impact the net's effectiveness, then the reduction in AI could result in cost reductions.
Methods:
Nine individual experimental hut trials were conducted to compare the efficacy of three different hybrid net designs relative to fully treated nets; roof-only treated nets, side-only treated nets, and nets with treated roof and pyrethroid-only side panels. These trials were conducted on a range of net products with different AIs, across a range of geographies in Africa (East and West), vector species (An. gambiae, An. coluzzii, An. arabiensis, and An. funestus), hut designs (east and west African style) and hosts (cows and humans). The combined data from these trials were analysed in a meta-analysis, and odds ratios for the effect of the different net designs on mortality and blood-feeding were estimated using mixed effects logistic regression.
Results:
The results of this meta-analysis demonstrated that fully treated nets provide greater mosquito killing and reduction in blood-feeding effects than any configuration of insecticide treatment restricted to specific panels.
Conclusions:
This meta-analysis showed that hybrid net strategies that restrict the insecticide treatment to specific panels of an ITN do not give equivalency or superiority in either mortality or blood-feeding inhibition to fully treated nets. The implications of these findings are discussed.
Experimental study on ultrasonic reduction of irreducible water saturation in low permeability reservoir
Authors: Qiang HUA , liu pengcheng , li guangpu , yang fengmin , liu xiaoxiao 
Published: April 2024

Abstract

Using the self-developed ultrasonic generator, the natural low permeability cores of different physical properties were selected to carry out the indoor oil flooding experiment, and the effect of ultrasonic action on the saturation of irreducible water in low-permeability reservoirs was evaluated. It was found that ultrasound can further reduce the saturation of irreducible water on the basis of oil flooding. The influence of different frequencies of ultrasound on the saturation of reservoir core irreducible water is different, and there is an optimal range of ultrasonic frequencies. Increasing the ultrasonic power can effectively reduce the saturation of the core irreducible water in the low-permeability reservoir, and increasing the ultrasonic power can compensate for the adverse effects caused by the increase in frequency. With the increase of ultrasonic power, the thickness of the water film first decreases rapidly, and then gradually stabilizes. The effect of ultrasound on the reduction of the saturation of irreducible water gradually deteriorates, with the increase of temperature, and at a higher temperature of 70°C, the ultrasonic effect can still reduce the saturation of irreducible water. The effect of ultrasound on the saturation of irreducible water at low temperature is more intense, and the ultrasonic effect is more suitable for low temperature treatment. The effect of ultrasound on the reduction of saturation of irreducible water in reservoirs with poor physical properties is more obvious.