bluuebunny/crossref_metadata_2025_split huggingface dataset:
How the discovery of Cold Noise delayed the production of ATLAS ITk strip tracker modules by a year
Authors: Dyckes G.I. , Kurth M.G. ,   the ITk Strip collaboration
Published: April 2024

Abstract
The construction of the ATLAS strip tracker barrel will require the assembly of 12,000 barrel detector modules over the course of 3.5 years. In 2022, during the module pre-production phase, modules were found to display clusters of noisy channels outside required specifications when tested at operating temperatures (-35°C), called “Cold Noise”. Extensive investigations into the cause and mechanism of Cold Noise interrupted pre-production and occupied most barrel module assembly sites. This contribution presents an overview of the year-long investigations into Cold Noise, the final identification of the underlying mechanism and necessary changes for the transition to production.
Optimizing time resolution and power consumption in a current-mode circuit for SiPMs
Authors: Manera R. , Gómez S. , Mariscal-Castilla A. , Mauricio J. , Ballabriga R. , Gascón D. 
Published: April 2024

Abstract
Several applications that employ SiPMs require high time precision readout electronics. This work presents a study for the optimization of timing resolution of readout electronics for SiPMs focused on the effect of sensor area, transistor scaling and power consumption on electronic jitter. The design of the most critical stages are presented, specially the front-end input stage in current-mode. The performance of three different technologies (180, 130 and 65 nm) are studied. 65 nm is the best option to obtain good timing resolution with less power consumption. Dividing the sensor into smaller segments improves the Single Photon Electronics Jitter (SPEJ), but does not translate into a better Coincidence Time Resolution (CTR) when keeping the power per unit area constant, performing analog summation or employing an averaging algorithm of the time stamps for small LSO:Ce:%0.2Ca scintillator crystal.
Living emission abolish filters (LEAFs) for methane mitigation: design and operation
Authors: Hamilton Richard , Griffith Nicholas , Salamon Peter , Handler Robert , Kalyuzhnaya Marina G 
Published: April 2024

Abstract
As one of the most potent greenhouse gases, methane is a critical target for the near-term mitigation of global warming. Efficient, scalable, easy-to-implement, and robust mitigation technologies are urgently needed to assist in reaching methane abolishment. The goal of this research was to test the applicability of active, extremophilic methanotrophic cells as a baseline concept for engineered systems aiming at methane capturing. The system, named living emission abolish filters (LEAFs), represents an array of immobilized biomaterials capable of capturing methane directly from vent streams. The biomaterials were made using cells of Methylotuvimicrobium alcaliphilum 20ZR, a robust halophilic methanotrophic bacterium with the ability to consume methane gas at low concentrations. Several critical parameters were tested, including (i) the composition of the matrix and optimal immobilization to increase catalyst load, (ii) the stability of methanotrophic cells, and (iii) the toxicity of trace gases (i.e. CO). We found that hydrogels coated with 2.3 mg cell dry weight/cm3 methanotrophic cells represent the best-performing biomaterials. The methane reduction potential of LEAFs fluctuated from 20% to 95% and depended on the methane concentration in the gas stream and the stream flow rates. The potential for commercial-scale deployment and emissions reductions was also evaluated. Total greenhouse gas emissions (combined using the global warming potential GWP100) from an example using a ventilation air methane source over a one-year period was shown to be reduced in two LEAF scenarios by 51% and 75%. Over longer time horizons, more significant reductions are possible as consistent methane consumption can be sustained. The study highlights the overall potential of the liquid-free bio-based composite methane mitigation system. Further improvements essential for system assembly and implementations should include (a) optimization of the cell immobilization protocols to improve cell load and the shelf-life of the system and (b) implementation of matrix moldings for cell immobilization to achieve optimal gas flow and increase the cell-gas interface.
Genome structural dynamics: insights from Gaussian network analysis of Hi-C data
Authors: Banerjee Anupam , Zhang She , Bahar Ivet 
Published: April 2024

Abstract
Characterization of the spatiotemporal properties of the chromatin is essential to gaining insights into the physical bases of gene co-expression, transcriptional regulation and epigenetic modifications. The Gaussian network model (GNM) has proven in recent work to serve as a useful tool for modeling chromatin structural dynamics, using as input high-throughput chromosome conformation capture data. We focus here on the exploration of the collective dynamics of chromosomal structures at hierarchical levels of resolution, from single gene loci to topologically associating domains or entire chromosomes. The GNM permits us to identify long-range interactions between gene loci, shedding light on the role of cross-correlations between distal regions of the chromosomes in regulating gene expression. Notably, GNM analysis performed across diverse cell lines highlights the conservation of the global/cooperative movements of the chromatin across different types of cells. Variations driven by localized couplings between genomic loci, on the other hand, underlie cell differentiation, underscoring the significance of the four-dimensional properties of the genome in defining cellular identity. Finally, we demonstrate the close relation between the cell type–dependent mobility profiles of gene loci and their gene expression patterns, providing a clear demonstration of the role of chromosomal 4D features in defining cell-specific differential expression of genes.
Blood Biomarkers for the Management of Mild Traumatic Brain Injury in Clinical Practice
Authors: Oris Charlotte , Kahouadji Samy , Bouvier Damien , Sapin Vincent 
Published: April 2024

Abstract

Background
Despite the use of validated guidelines in the management of mild traumatic brain injury (mTBI), processes to limit unnecessary brain scans are still not sufficient and need to be improved. The use of blood biomarkers represents a relevant adjunct to identify patients at risk for intracranial injury requiring computed tomography (CT) scan.

Content
Biomarkers currently recommended in the management of mTBI in adults and children are discussed in this review. Protein S100 beta (S100B) is the best-documented blood biomarker due to its validation in large observational and interventional studies. Glial fibrillary acidic protein (GFAP) and ubiquitin carboxyterminal hydrolase L-1 (UCH-L1) have also recently demonstrated their usefulness in patients with mTBI. Preanalytical, analytical, and postanalytical performance are presented to aid in their interpretation in clinical practice. Finally, new perspectives on biomarkers and mTBI are discussed.

Summary
In adults, the inclusion of S100B in Scandinavian and French guidelines has reduced the need for CT scans by at least 30%. S100B has significant potential as a diagnostic biomarker, but limitations include its rapid half-life, which requires blood collection within 3 h of trauma, and its lack of neurospecificity. In 2018, the FDA approved the use of combined determination of GFAP and UCH-L1 to aid in the assessment of mTBI. Since 2022, new French guidelines also recommend the determination of GFAP and UCH-L1 in order to target a larger number of patients (sampling within 12 h post-injury) and optimize the reduction of CT scans. In the future, new cut-offs related to age and promising new biomarkers are expected for both diagnostic and prognostic applications.
Authoritarian Resistance and Judicial Complicity: Turkey and the European Court of Human Rights
Authors: Kurban Dilek 
Published: April 2024

Abstract
International courts face growing contestations to their authority. Scholars have conceptualized the forms and grounds of such resistance as well as the response of international courts. Much empirical research has focused on regional courts with human rights mandates. Yet, in focusing on overt resistance, not differentiating between authoritarian and democratic regimes, and depicting courts at the receiving end of resistance, scholarship does not account for discrete forms of resistance tolerated and enabled by courts. In addition, studies on the European Court of Human Rights (ECtHR) base their analyses exclusively on judgments, which constitute a mere 9 per cent of this Court’s jurisprudence. This methodological bias, combined with a time frame limited to the post-2010s when the ECtHR has faced public contestations to its authority, have led to inaccurate and incomplete conclusions regarding the Strasbourg Court’s response to backlash and illiberalism. This article calls for a goal-orientated conceptualization of resistance and a methodology that analyses the ECtHR’s non-judgment jurisprudence in its entirety to reach accurate conclusions on its response to authoritarianism. Based on an in-depth and contextual analysis of the ECtHR-Turkey case, the article puts forth empirically grounded insights on authoritarian resistance and judicial complicity. It argues that authoritarian regimes seek to lessen international courts’ oversight of their policies, not to undermine the authority of these courts as such, and that international courts are not always resilient vis-à-vis authoritarian resistance but can also be complicit with it. The forms of authoritarian resistance and judicial response depend on the institutional set-up of the human rights regime in question as well as the ways in which international courts exercise their review powers. The two phenomena influence and reinforce each other, resulting in the simultaneous or consecutive occurrence of various forms of authoritarian resistance and judicial response depending on the particular political context in which they interact.
Impact of preventive substrate catheter ablation on implantable cardioverter-defibrillator interventions in patients with ischaemic cardiomyopathy and infarct-related coronary chronic total occlusion
Authors: Žižek David , Mrak Miha , Jan Matevž , Zupan Mežnar Anja , Ivanovski Maja , Žlahtič Tadej , Kajdič Nina , Antolič Bor , Klemen Luka , Skale Rafael , Avramovič Gregorič Jurij , Štublar Jernej , Pernat Andrej , Šinkovec Matjaž 
Published: April 2024

Abstract

Aims
Primary prevention patients with ischaemic cardiomyopathy and chronic total occlusion of an infarct-related coronary artery (CTO) are at a particularly high risk of implantable cardioverter-defibrillator (ICD) therapy occurrence. The trial was designed to evaluate the efficacy of preventive CTO-related substrate ablation strategy in ischaemic cardiomyopathy patients undergoing primary prevention ICD implantation.

Methods and results
The PREVENTIVE VT study was a prospective, multicentre, randomized trial including ischaemic patients with ejection fraction ≤40%, no documented ventricular arrhythmias (VAs), and evidence of scar related to the coronary CTO. Patients were randomly assigned 1:1 to a preventive substrate ablation before ICD implantation or standard therapy with ICD implantation only. The primary outcome was a composite of appropriate ICD therapy or unplanned hospitalization for VAs. Secondary outcomes included the primary outcome’s components, the incidence of appropriate ICD therapies, cardiac hospitalization, electrical storm, and cardiovascular (CV) mortality. Sixty patients were included in the study. During the mean follow-up of 44.7 ± 20.7 months, the primary outcome occurred in 5 (16.7%) patients undergoing preventive substrate ablation and in 13 (43.3%) patients receiving only ICD [hazard ratio (HR): 0.33; 95% confidence interval (CI): 0.12–0.94; P = 0.037]. Patients in the preventive ablation group also had fewer appropriate ICD therapies (P = 0.039) and the electrical storms (Log-rank: P = 0.01). While preventive ablation also reduced cardiac hospitalizations (P = 0.006), it had no significant impact on CV mortality (P = 0.151).

Conclusion
Preventive ablation of the coronary CTO-related substrate in patients undergoing primary ICD implantation is associated with the reduced risk of appropriate ICD therapy or unplanned hospitalization due to VAs.
Planned oocyte cryopreservation: a systematic review and meta-regression analysis
Authors: Hirsch Ayala , Hirsh Raccah Bruria , Rotem Reut , Hyman Jordana H , Ben-Ami Ido , Tsafrir Avi 
Published: April 2024

Abstract

BACKGROUND
Awareness of the age-related decline in fertility potential has increased the popularity of planned oocyte cryopreservation (POC). However, data regarding outcomes of POC, including rates of women returning to thaw oocytes, as well as pregnancy and live birth rates, are scarce and based mostly on small case series.

OBJECTIVE AND RATIONALE
POC was defined as cryopreservation exclusively for prevention of future age-related fertility loss. The primary outcome was live birth rate per patient. The secondary outcomes included the return to thaw rate and laboratory outcomes. A meta-regression analysis examining the association between live birth and age above 40 or below 35 was conducted.

SEARCH METHODS
We conducted a systematic database search from inception to August 2022. The search included PubMed (MEDLINE) and EMBASE. Our search strategies employed a combination of index terms (Mesh) and free text words to compile relevant concepts. The systematic review and meta-regression were undertaken following registration of systematic review (PROSPERO registration number CRD42022361791) and were reported following guidelines of Preferred Reporting Items for Systematic Review and Meta-Analyses 2020 (PRISMA 2020).

OUTCOMES
The database search yielded 3847 records. After the selection process, 10 studies, conducted from 1999 to 2020, were included. Overall, 8750 women underwent POC, with a mean cryopreservation age of 37.2 (±0.8). Of those, 1517 women returned to use their oocytes with a return rate of 11.1% (± 4.7%). The mean age at the time of cryopreservation for women who returned to use their oocytes was 38.1 (±0.4), with an average of 12.6 (±3.6) cryopreserved oocytes per woman. In a meta-analysis, the oocyte survival rate was 78.5% with a 95% CI of 0.74–0.83 (I2 = 93%). The live birth rate per patient was 28% with a 95% CI of 0.24–0.33 (I2 = 92%). Overall, 447 live births were reported. In a sub-group analysis, women who underwent cryopreservation at age ≥40 achieved a live birth rate per patient of 19% (95% CI 0.13–0.29, I2 = 6%), while women aged ≤35 years old or younger had a higher live birth rate per patient of 52% (95% CI 0.41–0.63, I2 = 7%).

WIDER IMPLICATIONS
POC emerges as a feasible option for women aiming to improve their chances of conceiving at a later reproductive age. Nonetheless, it must be acknowledged that the overall success rates of POC are limited and that the likelihood of successful live birth declines as the age at cryopreservation rises. With increasing interest in POC, the collation of comprehensive and high-quality data is imperative to clearly define the outcomes for various age groups.

REGISTRATION NUMBER
CRD42022361791.
What Contributes to the Minimum Inhibitory Concentration? Beyond β-Lactamase Gene Detection in Klebsiella pneumoniae
Authors: Maclean Alyssa K W , Morrow Stacey , Niu Fang , Hanson Nancy D 
Published: April 2024

Abstract

Background
Klebsiella pneumoniae is capable of resistance to β-lactam antibiotics through expression of β-lactamases (both chromosomal and plasmid-encoded) and downregulation of outer membrane porins. However, the extent to which these mechanisms interplay in a resistant phenotype is not well understood. The purpose of this study was to determine the extent to which β-lactamases and outer membrane porins affected β-lactam resistance.

Methods
Minimum inhibitory concentrations (MICs) to β-lactams and inhibitor combinations were determined by agar dilution or Etest. Outer membrane porin production was evaluated by Western blot of outer membrane fractions. β-lactamase carriage was determined by whole genome sequencing and expression evaluated by real-time reverse-transcription polymerase chain reaction.

Results
Plasmid-encoded β­-lactamases were important for cefotaxime and ceftazidime resistance. Elevated expression of chromosomal SHV was important for ceftolozane-tazobactam resistance. Loss of outer membrane porins was predictive of meropenem resistance. Extended-spectrum β-lactamases and plasmid-encoded AmpCs (pAmpCs) in addition to porin loss were sufficient to confer resistance to the third-generation cephalosporins, piperacillin-tazobactam, ceftolozane-tazobactam, and meropenem. pAmpCs (CMY-2 and DHA) alone conferred resistance to piperacillin-tazobactam.

Conclusions
Detection of a resistance gene by whole genome sequencing was not sufficient to predict resistance to all antibiotics tested. Some β-lactam resistance was dependent on the expression of both plasmid-encoded and chromosomal β-lactamases and loss of porins.
Transient States and Timeless Ties: (In)Formality, Power Networks, and the EU Mission in Kosovo
Authors: Tripathi Siddharth , Richter Solveig 
Published: April 2024

Abstract
State-building by external actors can be understood as a practice of intervention in post-conflict spaces characterized by convergences and contestations between different actors striving for power and legitimacy. Informal non-state (armed) groups and clientele networks profit from the contingencies during transition and “capture” emerging formal state institutions to secure private gains and public positions. Order in this newly formed state is established through a dynamic process involving both external actors and domestic power networks. Most of the literature on intervention either focuses on top-down effects of external actors or resistance by local actors, thus falling short of describing the timeless ties of post-war networks and individuals in their day-to-day interaction patterns. How can we then understand the interaction and collusion between post-conflict power networks and external “statebuilders”? We use Bourdieu’s concept of the field to examine the local spaces of interventions and argue that interventions are social and relational practices characterized by day-to-day routines and overlapping, yet co-existing modes of formal and informal interactions. Empirically, we rely on qualitative social network analysis and interviews to visibilize these social practices and collusion between external actors and power networks in Kosovo and its impact on “state-building” efforts by the international community.
Plasma concentrations of antiretroviral drugs in a successful 4-days-a-week maintenance treatment strategy in HIV-1 patients (ANRS 170-Quatuor trial)
Authors: Abe Emuri , Landman Roland , Assoumou Lambert , Amat Karine , Lambert-Niclot Sidonie , Bellet Jonathan , Gibowski Séverine , Girard Pierre-Marie , Morand-Joubert Laurence , de Truchis Pierre , Alvarez Jean-Claude 
Published: April 2024

Abstract

Objectives
Charaterization of the plasma concentrations of antiretrovirals in a 4-days-a-week maintenance treatment strategy in the ANRS-170-QUATUOR study.

Methods
Patients were randomized in two groups receiving triple therapy taken 4-days-ON and 3-days-OFF (4/7) or continuous therapy (7/7). Plasma antiretroviral concentrations were monitored during the ‘ON-treatment period’ (Day 3 or 4 of the 4-day treatment block) and the ‘OFF-treatment period’ (Day 3 of the 3-day drug cessation) for the 4/7 group, or before the daily drug intake for the 7/7 group, until week-48 (W48). After W48, all patients switched to the 4/7 strategy and were followed until W96.

Results
W0 measured concentrations were comparable in both groups, except for raltegravir, concentrations of which were higher in the 4/7 group, and were all above the values usually recommended to be effective in therapeutic drug monitoring. Comparison of ON-period median concentrations between the two groups showed a statistical difference for rilpivirine [88 ng/mL (interquartile range (IQR) = 64–112) for 4/7 arm versus 130 ng/mL (82–160) for 7/7 arm, P &lt; 0.001] and tenofovir [tenofovir disoproxil fumarate: 93 ng/mL (73–135) for 4/7 arm versus 117 ng/mL (83–160) for 7/7 arm, P &lt; 0.001; tenofovir alafenamide: 11 ng/mL (7–15) for 4/7 arm versus 14 ng/mL (11–18) for 7/7 arm, P = 0.001]. Median OFF concentrations were significantly lower (P &lt; 0.001) at the 48 week analysis for all medications except for raltegravir (P = 0.493) and atazanavir (P = 0.105), for which the numbers of patients were very small.

Conclusions
The 4/7-day treatment option led to antiretroviral blood levels close to continuous treatment after the four consecutive days of medication, and to low levels at the end of the non-treatment period.
Genomic estimated breeding values for bovine respiratory disease resistance in Angus feedlot cattle
Authors: Hayes Ben J , Duff Christian J , Hine Bradley C , Mahony Timothy J 
Published: April 2024

Abstract
Bovine respiratory disease (BRD) causes major losses in feedlot cattle worldwide. A genetic component for BRD resistance in feedlot cattle and calves has been reported in a number of studies, with heritabilities ranging from 0.04 to 0.2. These results suggest selection could be used to reduce the incidence of BRD. Genomic selection could be an attractive approach for breeding for BRD resistance, given the phenotype is not likely to be recorded on breeding animals. In this study, we derived GEBVs for BRD resistance and assessed their accuracy in a reasonably large data set recorded for feedlot treatment of BRD (1213 Angus steers, in two feedlots). In fivefold cross validation, genomic predictions were moderately accurate (0.23 ± 0.01) when a BayesR approach was used. Expansion of this approach to include more animals and a diversity of breeds is recommended to successfully develop a GEBV for BRD resistance in feedlots for the beef industry.
Simulation and analysis of the transient electromagnetic method response in double-layer water-filled goaf in coal mines
Authors: Yu Chuantao , Ma Jie , Xue Junjie 
Published: April 2024

Abstract
The resolution ability of the transient electromagnetic method (TEM) for double-layer water-filled goaf is affected by the low resistance shielding effect of the overlying strata. Currently, there is a lack of quantitative research on how the parameter changes of the upper water-filled goaf affect its resolution capability. In this study, through numerical and physical simulations, the relative error of the TEM response between single- and double-layer water-filled goafs was regarded as the evaluation index to analyse and summarize the resolution capability of the TEM for double-layer water-filled goaf under different burial depths, thicknesses, and areas of the upper water-filled goaf. The results are summarized as follows. (ⅰ) The resolution capability of the TEM for double-layer water-filled goaf decreased with the increasing burial depth, thickness, or area of the upper water-filled goaf. (ⅱ) The rate of decrease in resolution gradually accelerated as the burial depth increased. Conversely, as the thickness increased, the decrease rate in resolution gradually reduced. Furthermore, the resolution decreased rapidly and then tended towards a fixed value as the area increased. (ⅲ) The maximum value of the relative error curve moved towards the early stage with the increasing burial depth, resulting in a detection depth of the target body smaller than the actual value. Moreover, it moved towards the later stage with the increasing thickness or area, resulting in a detection depth of the target body greater than the actual value.