bluuebunny/crossref_metadata_2025_split huggingface dataset:
No effect of 12 weeks' supplementation with 1 g DHA-rich or EPA-rich fish oil on cognitive function or mood in healthy young adults aged 18–35 years
Authors: Jackson Philippa A. , Deary Michael E. , Reay Jonathon L. , Scholey Andrew B. , Kennedy David O. 
Published: August 2011

Then-3 PUFA are a unique class of fatty acids that cannot be manufactured by the body, and must be acquired via dietary sources. In the UK, as well as in other Western nations, these ‘essential’ fatty acids are consumed in quantities that fall below government guidelines. The present study explored the effects of 12 weeks' dietary supplementation with 1 g/d of two types of fish oil (FO; DHA-rich and EPA-rich) in 159 healthy young adults aged 18–35 years. An assessment of performance on a battery of computerised cognitive tasks and mood measures took place before and following the 12-week treatment regimen. Venous blood samples were also supplied by participants at both time points which were later analysed for serum fatty acid concentrations. Despite good adherence to the study protocol – as reflected in increased concentrations ofn-3 serum fatty acids – compared with placebo, the observed effects of both active treatments were minimal. The only finding of note revealed that supplementation with EPA-rich FO may reduce subjective mental fatigue at times of high cognitive demand, although further investigation is required. These findings, taken together with other recent reports of null effects, suggest that dietary supplementation withn-3 PUFA in healthy, normally developing and impairment-free populations is unlikely to result in cognitive enhancement.
Isolation and identification of an AP2/ERF factor that binds an allelic cis-element of rice gene LRK6
Authors: WANG QIANJIE , QI WEIWEI , WANG YING , SUN FAN , QIAN XIAOYIN , LUO XIAOJIN , YANG JINSHUI 
Published: August 2011

SummaryAllelic expression of the rice yield-related gene, leucine-rich receptor-like kinase 6 (LRK6), in the hybrid of 93-11 (Oryza sativa L. subsp. Indica var. 93-11) and Nipponbare (O. sativa L. subsp. Japonica var. Nipponbare) is determined by allelic promoter cis-elements. Using deletion analysis of the LRK6 promoter, we identified two distinct regions that might contribute to LRK6 expression. Sequence alignment revealed differences in these LRK6 promoter regions in 93-11 and Nipponbare. One of the segments, named differential sequence of LRK6 promoter 2 (DSLP2), contains potential transcription factor binding sites. Using a yeast one-hybrid assay, we isolated an ethylene-responsive factor (ERF) protein that binds to DSLP2. Sequence analysis and a GCC-box assay showed that the ERF gene, O. sativa ERF 3 (OsERF3), which belongs to ERF subfamily class II, has a conserved ERF domain and an ERF-associated amphiphilic repression repressor motif. We used an in vivo mutation assay to identify a new motif (5′-TAA(A)GT-3′) located in DSLP2, which interacts with OsERF3. These results suggest that OsERF3, an AP2 (APETALA 2 Gene)/ERF transcription factor, binds the LRK6 promoter at this new motif, which might cause differential expression of LRK6 in the 93-11/Nipponbare hybrid.
An anatomical study of the myelination of human laryngeal nerves
Authors: Fleming J C , Gibbins N , Ingram P J , Harries M 
Published: August 2011

AbstractObjective:To determine the differences in myelination between the human recurrent laryngeal nerve and superior laryngeal nerve.Methods:Fifteen confirmed laryngeal nerve specimens were harvested from five cadavers. Cross-sections were examined under a photomicroscope and morphometric analysis performed.Results:There was a significantly greater number of myelinated fibres than unmyelinated fibres, in both the recurrent laryngeal nerve (p = 0.018) and the superior laryngeal nerve (p = 0.012). There was a significantly greater number of myelinated fibres in the superior laryngeal nerve, compared with the recurrent laryngeal nerve (p = 0.028). However, there was no significant difference in the number of unmyelinated fibres, comparing the two nerves (p = 0.116).Conclusion:These findings support those of previous studies, and provide further evidence against the historical plexus theory of laryngeal nerve morphology. The differences in the degree of myelination, both within and between the human laryngeal nerves, may have clinical consequence regarding recovery of function following nerve injury.
A longitudinal etiologic model for symptoms of anxiety and depression in women
Authors: Kendler K. S. , Gardner C. O. 
Published: August 2011

BackgroundDesigned as state measures to monitor treatment response, symptoms of anxiety and depression (SxAnxDep) also have trait-like characteristics. No comprehensive etiologic model for SxAnxDep has illuminated the inter-relationship between their state- and trait-like characteristics, while including key predictor variables.MethodIn a prospective three-wave study of 2395 female twins from the Virginia Adult Twin Study of Psychiatric and Substance Use Disorders (VATSPSUD), we examined, using structural equation modeling, how genes, childhood and past-year environmental stressors, personality and episodes of major depression (MD) and generalized anxiety disorder (GAD) influence SxAnxDep.ResultsThe best-fit model, which explained 68–74% of the variance in SxAnxDep, revealed two etiologic pathways. Stable levels of SxAnxDep resulted largely from neuroticism, which in turn was influenced by genetic and early environment risk factors. Occasion-specific influences resulted from stressful events mediated through episodes of MD or GAD. These two pathways, which had approximately equal influences on levels of SxAnxDep, were substantially correlated because the genetic, early environmental and personality factors that impacted on stable symptom levels also predisposed to event exposure and disorder onset. No significant interaction was seen between the two pathways.ConclusionsSxAnxDep in women in the general population arise from two inter-related causal pathways. The first, the ‘trait-like’ pathway, reflects genetic and early environmental risk factors, and is mediated largely through personality. The second pathway is mediated through episodes of MD and GAD, and is the result of both recent environmental adversities and trait-like factors that influence event exposure and the probability of disorder onset.
Wittgenstein on the language of rituals: the scapegoat remark reconsidered
Authors: HOYT CHRISTOPHER 
Published: August 2011

AbstractWittgenstein's remarks on religion suggest a provocative and nuanced account of what makes rituals meaningful – and why some living rituals might have little or no meaning despite their hold on congregants. Wittgenstein's view has been obscured, I argue, in part by the consistent misinterpretation of his controversial ‘scapegoat remark’, which has been taken to be a comment on the internal incoherence of the ancient Jewish scapegoat rite. In fact, Wittgenstein's point is that the scapegoat ritual is particularly easy to misinterpret, and so reflection on it helps illustrate the sort of confusion that plagues much thinking about religion and ritual.
Keeping Bayesian models rational: The need for an account of algorithmic rationality
Authors: Danks David , Eberhardt Frederick 
Published: August 2011

AbstractWe argue that the authors’ call to integrate Bayesian models more strongly with algorithmic- and implementational-level models must go hand in hand with a call for a fully developed account of algorithmic rationality. Without such an account, the integration of levels would come at the expense of the explanatory benefit that rational models provide.
Don't throw out the Bayes with the bathwater
Authors: Fernbach Philip M. , Sloman Steven A. 
Published: August 2011

AbstractWe highlight one way in which Jones & Love (J&L) misconstrue the Bayesian program: Bayesian models do not represent a rejection of mechanism. This mischaracterization obscures the valid criticisms in their article. We conclude that computational-level Bayesian modeling should not be rejected or discouraged a priori, but should be held to the same empirical standards as other models.
What the Bayesian framework has contributed to understanding cognition: Causal learning as a case study
Authors: Holyoak Keith J. , Lu Hongjing 
Published: August 2011

AbstractThe field of causal learning and reasoning (largely overlooked in the target article) provides an illuminating case study of how the modern Bayesian framework has deepened theoretical understanding, resolved long-standing controversies, and guided development of new and more principled algorithmic models. This progress was guided in large part by the systematic formulation and empirical comparison of multiple alternative Bayesian models.
Reverse engineering the structure of cognitive mechanisms
Authors: Pietraszewski David , Wertz Annie E. 
Published: August 2011

AbstractDescribing a cognitive system at a mechanistic level requires an engineering task analysis. This involves identifying the task and developing models of possible solutions. Evolutionary psychology and Bayesian modeling make complimentary contributions: Evolutionary psychology suggests the types of tasks that human brains were designed to solve, while Bayesian modeling provides a rigorous description of possible computational solutions to such problems.
FP-INJECTIVE COMPLEXES AND FP-INJECTIVE DIMENSION OF COMPLEXES
Authors: WANG ZHANPING , LIU ZHONGKUI 
Published: August 2011

AbstractIn this paper we extend the notion of FP-injective modules to that of complexes and characterize such complexes. We show that some characterizations similar to those for injective complexes exist for FP-injective complexes. We also introduce and study the notion of an FP-injective dimension associated to every complex of left R-modules over an arbitrary ring. We show that there is a close connection between the FP-injective dimension of complexes and flat dimension.
A biogeographic distribution of magnetotactic bacteria influenced by salinity
Authors: Lin Wei , Wang Yinzhao , Li Bi , Pan Yongxin 
Published: August 2011

AbstractMagnetotactic bacteria (MTB), which synthesize intracellular ferromagnetic magnetite and/or greigite magnetosomes, have significant roles in global iron cycling in aquatic systems, as well as sedimentary magnetism. The occurrence of MTB has been reported in aquatic environments from freshwater to marine ecosystems; however, the distribution of MTB across heterogeneous habitats remains unclear. Here we examined the MTB communities from diverse habitats across northern and southern China, using comprehensive transmission electron microscopy and comparison of 16S rRNA gene analyses. A total of 334 16S rRNA gene sequences were analyzed, representing the most comprehensive analysis on the diversity and distribution of MTB to date. The majority (95%) of sequences belong to the Alphaproteobacteria, whereas a population of giant magnetotactic rod is affiliated with the Nitrospirae phylum. By a statistical comparison of these sequence data and publicly available MTB sequences, we infer for the first time that the composition of MTB communities represents a biogeographic distribution across globally heterogeneous environments, which is influenced by salinity.
Novel anti-diabetic effect of SCM-198 via inhibiting the hepatic NF-κB pathway in db/db mice
Authors: Huang Hui , Xin Hong , Liu Xinhua , Xu Yajun , Wen Danyi , Zhang Yahua , Zhu Yi Zhun 
Published: August 2011

There are reports of early evidence that suggest the involvement of chronic low-grade inflammation in the pathogenesis of Type 2 diabetes. Thus, substances that have effects in reducing inflammation could be potential drugs for Type 2 diabetes. Leonurine (4-guanidino-n-butyl syringate; SCM-198) is an alkaloid in HL (Herba leonuri), which was reported to possess anti-inflammatory properties. We hypothesize that SCM-198 may have beneficial effects on Type 2 diabetes. In the present study, we attempted to test this hypothesis by evaluating the anti-diabetic effect of SCM-198 and the possible underlying mechanisms of its effects in db/db mice. SCM-198 (50, 100 and 200 mg/kg of body weight), pioglitazone (50 mg/kg of body weight, as a positive control) or 1% CMC-Na (sodium carboxymethylcellulose) were administered to the db/db or db/m mice once daily for 3 weeks. After 3 weeks, SCM-198 (200 mg/kg of body weight) treatment significantly reduced the fasting blood glucose level and increased the plasma insulin concentration in the db/db mice, meanwhile it significantly lowered the plasma TAG (triacylglycerol) concentration and increased the HDL (high-density lipoprotein)-cholesterol concentration. Moreover, the dysregulated transcription of the hepatic glucose metabolic enzymes, including GK (glucokinase), G6Pase (glucose-6-phosphatase) and PEPCK (phosphoenolpyruvate carboxykinase), was recovered by an Akt-dependent pathway. The pro-inflammatory mediators {such as TNFα (tumour necrosis factor α), IL (interleukin)-6, IL-1β, degradation of IκB [inhibitor of NF-κB (nuclear factor-κB)] α and thereafter activation of NF-κB} were reversed by SCM-198 treatment in the db/db mice. The present study provides first evidence that SCM-198 exhibits anti-inflammatory activity and has an ameliorating effect on diabetic symptoms via inhibiting of NF-κB/IKK (IκB kinase) pathway. Consequently, we suggest that SCM-198 may be a prospective agent for prevention and/or moderation of the progress of Type 2 diabetes.
Role of Oral History in Preparing Biographies
Authors: Ladjevardi Habib 
Published: August 2011

Back in the fall of 1980, Edward Keenan, then Dean of the Graduate School of Arts and Sciences, Harvard University, asked whether I would organize an oral history project on Iran. A Soviet specialist, Keenan saw certain similarities between the Russian and the Iranian revolutions and considered the immigration to the West of hundreds of former Iranian officials to be an exceptional opportunity to collect and preserve valuable historical data.In our subsequent discussions it became clear that an in-depth study of the internal workings of Iran's former regime was difficult, as few reliable primary sources are available for this purpose. Because of the autocratic nature of Iran's political system, government papers, documents, and reports were (and still are) infrequently prepared prior to major decisions and subsequent to important events. Moreover, the relevant documents that were produced have not been preserved systematically and, in cases where they do exist, are not generally available to researchers.
Reliability and validity of judging in women's artistic gymnastics at University Games 2009
Authors: Bučar Maja , Čuk Ivan , Pajek Jernej , Karacsony Istvan , Leskošek Bojan 
Published: August 2011

AbstractThe aim of our research was to analyse the reliability and validity of judging on all women's apparatuses and all sessions (qualification, all round finals and apparatus finals) at the World University Games‐Universiade 2009 in Belgrade. For validity assessment, mean absolute and rank deviations of judges’ execution scores were calculated. For consistency and reliability assessment, Cronbach's alpha coefficient, intra‐class correlations, Armor's theta and Kendall's W coefficient were calculated. Vault and floor exercise finals were the sessions with the highest scores and the lowest score dispersion. The overall highest individual judge average absolute deviation was 0.34 point and the largest mean rank deviation was 0.88 with most values well below this. A correlation matrix for between‐judge correlations identified three judges (out of 20) in the apparatus finals sessions with remarkably inferior correlations with others. Except for vault and floor finals, the results in terms of consistency (Cronbach's alpha mostly above 0.95) and reliability (Armor's theta mostly above 0.94, intra‐class correlation for single and average measures above 0.87 and 0.94, respectively) were satisfactory. In conclusion, overall high values of reliability and consistency indices were found. Sessions where the variability between competitors is low (such as vault and floor finals in this competition) should be inspected with special care in future judging analyses.
Effect of warm‐up exercise on delayed‐onset muscle soreness
Authors: Takizawa Kazuki , Soma Toshio , Nosaka Kazunori , Ishikawa Tomoji , Ishii Kojiro 
Published: August 2011

AbstractIn this study, we wished to determine whether a warm‐up exercise consisting of 100 submaximal concentric contractions would attenuate delayed‐onset muscle soreness and decreases in muscle strength associated with eccentric exercise‐induced muscle damage. Ten male students performed two bouts of an elbow flexor exercise consisting of 12 maximal eccentric contractions with a warm‐up exercise for one arm (warm‐up) and without warm‐up for the other arm (control) in a randomized, counterbalanced order separated by 4 weeks. Muscle temperature of the biceps brachii prior to the exercise was compared between the arms, and muscle activity of the biceps brachii during the exercise was assessed by surface integral electromyogram (iEMG). Changes in visual analogue scale for muscle soreness and maximal voluntary isometric contraction strength (MVC) of the elbow flexors were assessed before, immediately after, and every 24 h for 5 days following exercise, and compared between the warm‐up and control conditions by a two‐way repeated‐measures analysis of variance. The pre‐exercise biceps brachii muscle temperature was significantly (P<0.01) higher for the warm‐up (35.8±0.2°C) than the control condition (34.4±0.2°C), but no significant differences in iEMG and torque produced during exercise were evident between conditions. Changes in muscle soreness and MVC were not significantly different between conditions, although these variables showed significant (P<0.05) changes over time. It was concluded that the warm‐up exercise was not effective in mitigating delayed‐onset muscle soreness and loss of muscle strength following maximal eccentric exercise.
Antisense Suppression of the Small Chloroplast Protein CP12 in Tobacco Alters Carbon Partitioning and Severely Restricts Growth
Authors: Howard Thomas P. , Fryer Michael J. , Singh Prashant , Metodiev Metodi , Lytovchenko Anna , Obata Toshihiro , Fernie Alisdair R. , Kruger Nicholas J. , Quick W. Paul , Lloyd Julie C. , Raines Christine A. 
Published: August 2011

Abstract
The thioredoxin-regulated chloroplast protein CP12 forms a multienzyme complex with the Calvin-Benson cycle enzymes phosphoribulokinase (PRK) and glyceraldehyde-3-phosphate dehydrogenase (GAPDH). PRK and GAPDH are inactivated when present in this complex, a process shown in vitro to be dependent upon oxidized CP12. The importance of CP12 in vivo in higher plants, however, has not been investigated. Here, antisense suppression of CP12 in tobacco (Nicotiana tabacum) was observed to impact on NAD-induced PRK and GAPDH complex formation but had little effect on enzyme activity. Additionally, only minor changes in photosynthetic carbon fixation were observed. Despite this, antisense plants displayed changes in growth rates and morphology, including dwarfism and reduced apical dominance. The hypothesis that CP12 is essential to separate oxidative pentose phosphate pathway activity from Calvin-Benson cycle activity, as proposed in cyanobacteria, was tested. No evidence was found to support this role in tobacco. Evidence was seen, however, for a restriction to malate valve capacity, with decreases in NADP-malate dehydrogenase activity (but not protein levels) and pyridine nucleotide content. Antisense repression of CP12 also led to significant changes in carbon partitioning, with increased carbon allocation to the cell wall and the organic acids malate and fumarate and decreased allocation to starch and soluble carbohydrates. Severe decreases were also seen in 2-oxoglutarate content, a key indicator of cellular carbon sufficiency. The data presented here indicate that in tobacco, CP12 has a role in redox-mediated regulation of carbon partitioning from the chloroplast and provides strong in vivo evidence that CP12 is required for normal growth and development in plants.
Children's pain perspectives
Authors: Esteve R. , Marquina‐Aponte V. 
Published: August 2011

AbstractBackground  Previous studies on children's pain perspectives remain limited to English‐speaking populations.Methods  An exploratory cross‐sectional descriptive design was used to investigate the developmental progression of children's pain perspectives, including their pain experience, its definition and attributes, causality and coping. The Children's Pain Perspectives Inventory was applied to 180 healthy Spanish children. A coding system was developed following the content analysis method. Three age groups were compared: 4–6 years, corresponding to the Piagetian pre‐operational stage of cognitive development; 7–11 years, corresponding to stage of concrete operations; and 12–14 years, corresponding to the period of early formal operations.Results  In children between 4 and 6, the predominant narratives related to physical injuries, the notion of causality and the definition of pain. In children between 7 and 11, the predominant narratives were those in which pain was described as a sensation in one part of the body. The view of pain as having an emotional basis significantly increased with age and was more frequent in adolescents. In contrast, children between 4–6 and 7–11 indicated that pain occurs spontaneously. The denial of any positive aspects of pain significantly decreased with age; some children between 7 and 11 referred to the ‘possibility of relief’, while the view that pain is a ‘learning experience’ was significantly more frequent among adolescents aged between 12 and 14 years. The use of cognitive strategies to control pain significantly increased with age. Between 12 and 14 years of age, adolescents communicate pain by non‐verbal behaviour and reported that they do not express demands for relief.Conclusions  There was a progression from concrete to more complex notions of pain as age increased. These results may be of use to health professionals and parents to understand how children at various developmental stages express and cope with pain and to develop tools that effectively assess and manage pain in children.