bluuebunny/crossref_metadata_2025_split huggingface dataset:
Attentional Foci and Coping Strategies During Matches of Young Fencers in a Training Center: A Naturalistic Video-Assisted Study
Authors: Maurin Mathéo , Bracco Maëlle , Le Pape Steven , Lienhart Noémie , Bossard Cyril , Doron Julie , Martinent Guillaume 
Published: June 2024

The purpose of this study was twofold: (a) identify attentional foci (AF) and coping strategies used by young fencers during matches and (b) explore the links between these variables using a grounded-theory approach. Using a naturalistic qualitative video-assisted approach, analyses revealed the emergence of five categories of AF (movements and techniques, strategies and tactics, situation evaluation, states, and extraneous attention) and six categories of coping strategies (mastery coping, internal regulation, goal-withdrawal strategies, behavioral regulation, no regulation, and automatic regulation). The grounded theory highlighted that pleasant emotional experiences tended to be related to mastery coping, which in turn favored the orientation of the attention toward AF that appeared to be most effective in winning points (i.e., opponent, distance, plan). Conversely, unpleasant emotional experiences were consistently associated with goal-withdrawal strategies (or no regulation), which generally led to a lack of AF and lower performance. Intervention suggestions are made in relation to the results of the proposed grounded theory.
Improved complete genome sequence of
Bdellovibrio bacteriovorus
109J, a widely studied laboratory strain of predatory bacteria
Authors: Hoshiko Yuki , Okuno Miki , Yamamoto Takeshi , Maeda Toshinari , Ogura Yoshitoshi 
Published: June 2024

ABSTRACT

The complete genome sequence of
Bdellovibrio bacteriovorus
109J, a well-studied laboratory strain of predatory bacteria, first determined in 2014. Here we report an improved complete genome sequence of
B. bacteriovorus
109J, incorporating 16 assembly and 87 nucleotide corrections. This revised genome will be helpful to studies on the predatory bacteria.
Discrimination of tectonic provinces using zircon U-Pb ages from bedrock and detrital samples in the northern Andes
Authors: Sandoval Jose Ricardo , Pérez-Consuegra Nicolás , Mora Andrés , Horton Brian K. , Parra Mauricio , Beltrán Alejandro , Gómez Ricardo Andrés , Ibanez Mauricio , Valencia Víctor 
Published: June 2024

Abstract
The northern Andes of southern Colombia contain a rich geologic history recorded by Proterozoic to Cenozoic metamorphic, igneous, and sedimentary rocks. The region plays a pivotal role in understanding the evolution of topography in northwestern South America and the development of large river systems, such as the Amazon, Orinoco, and Magdalena rivers. However, understanding of the basement framework has been hindered by challenging access, security concerns, tropical climate, and outcrop scarcity. Further, an insufficient geochronologic characterization of Andean basement complicates provenance interpretations of adjacent basins and restricts understanding of the paleogeographic evolution of southern Colombia. To address these issues, this paper presents a zircon U-Pb geochronological dataset derived for 24 bedrock samples and 19 modern river samples. The zircon U-Pb results reveal that the Eastern Cordillera of southern Colombia is underlain by basement rocks that originated in various tectonic events since ca. 1.5 Ga, including the accretion of discrete terranes. The oldest rocks, found in the Garzon Massif, are high-grade metamorphic rocks with contrasting Proterozoic protolith crystallization ages. Whereas the SW part of the massif formed during the Putumayo Orogeny (ca. 1.2–0.9 Ga), we report orthogneisses for the NE segment with protoliths formed at ca. 1.5 Ga, representing the NW continuation of the Rio Negro Jurena province of the Amazonian Craton. In contrast, crystalline rocks of the Central Cordillera primarily consist of Permian–Triassic (ca. 270–250 Ma) and Jurassic–Cretaceous (ca. 180–130 Ma) igneous rocks formed in a magmatic arc. In southernmost Colombia, the Putumayo Mountains mainly consist of Jurassic–Cretaceous (180–130 Ma) plutonic and volcanic rocks. Furthermore, we analyzed the heavy mineral abundances in modern river sands in southern Colombia (spanning 1°N–5°N) and found that key minerals such as garnet and epidote can be utilized to trace high-grade metamorphic and igneous lithologies, respectively, in the river catchments. The differentiation of basement ages for separate tectonic provinces, combined with heavy mineral abundances in modern sands, can serve as unique fingerprints in provenance analyses to trace the topographic and exhumational evolution of different Andean regions through time.
Utility and acceptability of remote 6-lead electrocardiographic monitoring in children with inherited cardiac conditions
Authors: Lawley Claire Margaret , Luczak-Wozniak Katarzyna , Chung Sheng-Chia , Field Ella , Barnes Annabelle , Starling Luke , Cervi Elena , Kaski Juan Pablo 
Published: June 2024

ObjectiveThis pilot study sought to investigate the utility and acceptability of the KardiaMobile 6-lead ECG (KM6LECG) as a tool for remote monitoring in children with inherited cardiac conditions.DesignA single-centre prospective cohort study. Children underwent standard clinical evaluation including a 12-lead ECG and a KM6LECG in the clinic. Participants recorded KM6LECGs monthly at home for 3 months. Families completed a questionnaire on their experience.SettingGreat Ormond Street Hospital Centre for Inherited Cardiovascular Diseases.Participants64 children: 22 with hypertrophic cardiomyopathy (HCM); 22 with long QT syndrome and 20 unaffected siblings (controls).Main outcome measuresComparison of data extracted from the clinic 12-lead ECG and supervised KM6LECG, and the supervised and unsupervised KM6LECG recording.ResultsOf 64 children (35% female, mean age 12 years), 58 had a baseline 12-lead ECG and appropriate baseline KM6LECG. In children with HCM, abnormalities in ventricular depolarisation/repolarisation in the limb leads of the 12-lead ECG were reliably reproduced. From the whole cohort, there was a strong positive correlation between the corrected QT interval from the 12-lead ECG and baseline KM6LECG (intraclass correlation coefficient=0.839) and baseline KM6LECG with an unsupervised KM6LECG (intraclass correlation coefficient=0.736). Suspected ‘lead’ misplacement impacted 18% of unsupervised recordings. Overall, the acceptability of the KM6LECG to families was good.ConclusionsThe KM6LECG provides an accurate tool for assessing some ECG abnormalities associated with paediatric inherited cardiovascular disease and may provide a useful at-home adjunct to face-to-face clinical care of children requiring ECG assessment.
How do we define therapy-resistant constipation in children aged 4–18 years old? A systematic review with meta-narrative synthesis
Authors: Sinopoulou Vassiliki , Gordon Morris , Rajindrajith Shaman , Hathagoda Watshala , Rane Aditi Bhupendra , Sedghi Anita , Tabbers Merit , Di Lorenzo Carlo , Saps Miguel , Benninga Marc A 
Published: June 2024

BackgroundTherapy-resistant constipation often is a frustrating clinical entity recognised by the persistence of infrequent and painful bowel movements faecal incontinence and abdominal pain despite intensive treatment. It is important to clearly define therapy-resistant constipation before children are subjected to invasive diagnostic and therapeutic procedures.AimTo conduct a systematic review determining how paediatric interventional studies define therapy-resistant constipation.MethodWe searched CENTRAL, MEDLINE, Embase, WHO ICTR and ClinicalTrials.gov. Studies that included patients with therapy-resistant constipation were identified. Data were extracted on criteria used for defining therapy-resistant constipation and reported using a meta-narrative approach highlighting areas of convergence and divergence in the findings.ResultsA total of 1553 abstracts were screened in duplicate, and 47 studies were included in the review. There were at least seven definitions used in the paediatric literature to define medically resistant constipation. The term intractable was used in 24 articles and 21 used the term refractory to describe therapy-resistant constipation. Out of them, only 14 articles have attempted to provide an explicit definition including a predefined time and prior therapy. There were 10 studies without a clear definition for therapy-resistant constipation. The duration before being diagnosed as therapy-resistant constipation varied from 1 months to 2 years among studies. Seven studies employed the Rome criteria (Rome III or Rome IV) to characterising constipation while five adopted the Rome III and European and North American paediatric societies definition of paediatric gastroenterology, hepatology and nutrition guideline of management of constipation in children.ConclusionThe current literature has no explicit definition for therapy-resistant constipation in children. There is a need for a detailed consensus definition to ensure consistency of future research and to avoid unnecessary and maybe even harmful, invasive diagnostic and therapeutic interventions.
Assessing venous invasion in stage II colon cancer: optimal elastin stains and survival analysis
Authors: Lee Soo Hyun , Yilmaz Omer , Padmanabha Nandan , Deshpande Vikram , Yilmaz Osman 
Published: June 2024

AimsVenous invasion (VI) in colorectal carcinoma influences treatment strategies, especially in early stages. Despite elastin staining effectiveness in detecting VI, guidelines for its routine application, including the optimal number of slides for staining, are limited.MethodsElastin staining was performed for VI assessment in patients with colorectal adenocarcinoma. Patients were categorised into two groups: single elastin stain group (SEG, n=248) and multiple elastin stain group (MEG, n=204).ResultsThe average number of elastin-stained blocks was 2±1.7, increasing to 3.3±1.9 in MEG. VI detection was significantly higher in patients in MEG (50.5%) compared with SEG (37.0%) (p=0.004). VI detection rate was higher in MEG (63.7%) than in SEG (46.0%) among patients with stage III–IV disease (p=0.011), but did not significantly differ among patients with stage I–II disease. Staining two blocks improved VI detection without additional gains from more stains. Compared with elastin performed on a single block, VI detected by elastin stain on two or more blocks did not significantly impact progression-free or disease-free survival with stage II patients.ConclusionsEmploying two elastin stains on separate blocks significantly enhances VI detection in colorectal carcinoma without additional benefits from more extensive staining. This study suggests that while increasing sensitivity for VI detection, staining beyond two blocks may not benefit prognostication and could be counterproductive, warranting further research. We emphasise the need for strategic use of the elastin stain and cautious interpretation of the increased detection sensitivity of multiple elastin stains.
Long-term survival follow-up for tebentafusp in previously treated metastatic uveal melanoma
Authors: Sacco Joseph J , Carvajal Richard D , Butler Marcus O , Shoushtari Alexander N , Hassel Jessica C , Ikeguchi Alexandra , Hernandez-Aya Leonel , Nathan Paul , Hamid Omid , Piulats Josep M , Rioth Matthew , Johnson Douglas B , Luke Jason J , Espinosa Enrique , Leyvraz Serge , Collins Laura , Holland Chris , Sato Takami 
Published: June 2024

BackgroundTebentafusp, a bispecific (gp100×CD3) ImmTAC, significantly improved overall survival (OS) outcomes for HLA-A*02:01+ adult patients with untreated metastatic uveal melanoma (mUM) and showed promising survival in previously treated mUM with 1-year OS of 62% in the primary analysis of study IMCgp100-102. Here we report long-term outcomes from this phase 1/2 study in pretreated mUM.Patients and methodsPatients with previously treated mUM received tebentafusp weekly intravenous at 20 µg dose 1, 30 µg dose 2 and either 54, 64, 68, or 73 µg (phase 1) or 68 µg (phase 2) dose 3+. The primary objective was overall response rate. Secondary objectives included OS and safety. OS was estimated by Kaplan-Meier methods. Association between OS and baseline covariates, on-treatment Response Evaluation Criteria in Solid Tumors (RECIST) response, baseline tumor biopsy and circulating-tumor DNA (ctDNA) changes were assessed.Results146 patients were treated with tebentafusp: 19 in phase 1 and 127 in phase 2. With a median follow-up duration of 48.5 months, the median OS was 17.4 months (95% CI, 13.1 to 22.8), and the 1-year, 2-year, 3-year and 4-year OS rates were 62%, 40%, 23% and 14%, respectively. Improved survival was associated with lower ctDNA baseline levels and greater ctDNA reductions by week 9 on-treatment, with 100% 1-year, 73% 2-year and 45% 3-year OS rates for patients with ctDNA clearance. Baseline gp100 expression was not associated with survival, despite more RECIST responses among patients with higher expression. No new safety signals were reported with long-term dosing.ConclusionsThis study represents the longest follow-up of a Tcell receptor bispecific to date and confirms the durable survival benefits achieved with tebentafusp in previously treated mUM with good tolerability long-term. A role for ctDNA reduction as an early indicator of clinical benefit was again suggested for patients treated with tebentafusp.
Extending the clinical spectrum of X-linked Tonne-Kalscheuer syndrome (TOKAS): new insights from the fetal perspective
Authors: Cuinat Silvestre , Quélin Chloé , Effray Claire , Dubourg Christèle , Le Bouar Gwenaelle , Cabaret-Dufour Anne-Sophie , Loget Philippe , Proisy Maia , Sauvestre Fanny , Sarreau Mélie , Martin-Berenguer Sophie , Beneteau Claire , Naudion Sophie , Michaud Vincent , Arveiler Benoit , Trimouille Aurélien , Macé Pierre , Sigaudy Sabine , Glazunova Olga , Torrents Julia , Raymond Laure , Saint-Frison Marie-Hélène , Attié-Bitach Tania , Lefebvre Mathilde , Capri Yline , Bourgon Nicolas , Thauvin-Robinet Christel , Tran Mau-Them Frédéric , Bruel Ange-Line , Vitobello Antonio , Denommé-Pichon Anne-Sophie , Faivre Laurence , Brehin Anne-Claire , Goldenberg Alice , Patrier-Sallebert Sophie , Perani Alexandre , Dauriat Benjamin , Bourthoumieu Sylvie , Yardin Catherine , Marquet Valentine , Barnique Marion , Fiorenza-Gasq Maryse , Marey Isabelle , Tournadre Danielle , Doumit Raïa , Nugues Frédérique , Barakat Tahsin Stefan , Bustos Francisco , Jaillard Sylvie , Launay Erika , Pasquier Laurent , Odent Sylvie 
Published: June 2024

IntroductionTonne-Kalscheuer syndrome (TOKAS) is a recessive X-linked multiple congenital anomaly disorder caused byRLIMvariations. Of the 41 patients reported, only 7 antenatal cases were described.MethodAfter the antenatal diagnosis of TOKAS by exome analysis in a family followed for over 35 years because of multiple congenital anomalies in five male fetuses, a call for collaboration was made, resulting in a cohort of 11 previously unpublished cases.ResultsWe present a TOKAS antenatal cohort, describing 11 new cases in 6 French families. We report a high frequency of diaphragmatic hernia (9 of 11), differences in sex development (10 of 11) and various visceral malformations. We report some recurrent dysmorphic features, but also pontocerebellar hypoplasia, pre-auricular skin tags and olfactory bulb abnormalities previously unreported in the literature. Although no clear genotype–phenotype correlation has yet emerged, we show that a recurrent p.(Arg611Cys) variant accounts for 66% of fetal TOKAS cases. We also report two new likely pathogenic variants inRLIM, outside of the two previously known mutational hotspots.ConclusionOverall, we present the first fetal cohort of TOKAS, describe the clinical features that made it a recognisable syndrome at fetopathological examination, and extend the phenotypical spectrum and the known genotype of this rare disorder.
Spinal cord stimulation attenuates paclitaxel-induced gait impairment and mechanical hypersensitivity via peripheral neuroprotective mechanisms in tumor-bearing rats
Authors: Bakare Ahmed Olalekan , Stephens Kimberly , Sanchez Karla R , Liu Vivian , Zheng Lei , Goel Vasudha , Guan Yun , Sivanesan Eellan 
Published: June 2024

BackgroundTaxanes such as paclitaxel (PTX) induce dose-dependent chemotherapy-induced peripheral neuropathy (CIPN), which is associated with debilitating chronic pain and gait impairment. Increased macrophage-related proinflammatory activities have been reported to mediate the development and maintenance of neuropathic pain. While spinal cord stimulation (SCS) has been used for a number of pain conditions, the mechanisms supporting its use for CIPN remain to be elucidated. Thus, we aimed to examine whether SCS can attenuate Schwann cell-mediated and macrophage-mediated neuroinflammation in the sciatic nerve of Rowlette Nude (RNU) rats with PTX-induced gait impairment and mechanical hypersensitivity.MethodsAdult male tumor-bearing RNU rats were used for this study examining PTX treatment and SCS. Gait and mechanical hypersensitivity were assessed weekly. Cytokines, gene expression, macrophage infiltration and polarization, nerve morphology and Schwann cells were examined in sciatic nerves using multiplex immunoassay, bulk RNA sequencing, histochemistry and immunohistochemistry techniques.ResultsSCS (50 Hz, 0.2 milliseconds, 80% motor threshold) attenuated the development of mechanical hypersensitivity (20.93±0.80 vs 12.23±2.71 grams, p<0.0096) and temporal gait impairment [swing (90.41±7.03 vs 117.27±9.71%, p<0.0076), and single stance times (94.92±3.62 vs 112.75±7.27%, p<0.0245)] induced by PTX (SCS+PTX+Tumor vs Sham SCS+PTX+Tumor). SCS also attenuated the reduction in Schwann cells, myelin thickness and increased the concentration of anti-inflammatory cytokine interleukin (IL)−10. Bulk RNA sequencing revealed differential gene expression after SCS, with 607 (59.2%) genes upregulated while 418 (40.8%) genes were downregulated. Notably, genes related to anti-inflammatory cytokines and neuronal growth were upregulated, while genes related to proinflammatory-promoting genes, increased M2γ polarization and decreased macrophage infiltration and Schwann cell loss were downregulated.ConclusionSCS may attenuate PTX-induced pain and temporal gait impairment, which may be partly attributed to decreases in Schwann cell loss and macrophage-mediated neuroinflammation in sciatic nerves.
Mix optimization for expansive soil stabilized with a novel waste material-based geopolymerization approach
Authors: Maheepala M.M.A.L.N. , Nasvi M.C.M. , Robert D.J. , Gunasekara C. , Kurukulasuriya L.C. 
Published: June 2024

Extensive areal distribution of expansive soil is a timely concern in engineering challenges. Geopolymers outperform conventional cement/lime treatment in expansive soil stabilization due to their superior mechanical and durability performance. However, the excessive cost and carbon footprint of commercial alkaline activators hinder geopolymer's widespread application. This study aims to derive a cost-effective, carbon-conscious mix to stabilize expansive soil using waste-based geopolymerization. Class F fly ash was activated via a novel solution of rice husk ash (RHA)-derived silicate and NaOH. Three factors (NaOH/RHA, NaOH molarity, mixing duration) were considered using the Taguchi method and utility concept for mix optimization, while further investigations were tailored to explore the effects of curing temperature (room temperature, 30 °C, and 40 °C) and the curing period (7, 14, and 28 days) on the strength development of treated soil. The results indicate that NaOH/RHA = 0.6, NaOH molarity = 3 mol/L, and a mixing duration of 40 min with curing temperatures of around 30 °C are ideal for maximizing the strength cost-effectively while significantly reducing the swell pressure (up to 28%). The shift from commercial Na2SiO3 to RHA-silicate is 89% cheaper and reduces the carbon footprint by 70%. The study benefits sustainable ground stabilization and efficient waste management.
Quintessence scalar field model in Weyl-type f(Q, T) gravity with wD – w′D analysis
Authors: Bhardwaj Vinod Kumar , Garg Priyanka 
Published: June 2024

In the present study, we explore the dynamical characteristics of the quintessence cosmological model in Weyl-type f( Q, T) gravity. Here, T represents the trace of the matter energy–momentum tensor, and Q symbolizes the non-metricity tensor. We propose a solution to the field equation using the specific parametrization in the form q = β z(1 + z)−1 + α, which depicts the necessary transition of cosmos from decelerating era to the current accelerating scenario. The values of model parameters are estimated as H0 = 69.8 ± 1.2, α = −0.64 ± 0.027, and β = 1.549 ± 0.079 using the Markov Chain Monte Carlo analysis and limiting the model with a joint dataset of Pantheon, baryon acoustic oscillation, and cosmic chronometer. We discuss the cosmic behavior of many features of the derived model like EoS parameters, energy density, and cosmic pressure. Further, we have also explored the cosmological behavior of the quintessence model in Weyl f( Q, T) gravity. We have described the cosmic behavior of the model by [Formula: see text] analysis. The diagnosis of the model is also performed using statefinders and jerk parameters. In the end, we have discussed the energy conditions for the proposed model.
Metric-affine cosmological models and the inverse problem of the calculus of variations. Part 1: variational bootstrapping – the method
Authors: Ducobu Ludovic , Voicu Nicoleta 
Published: June 2024

AbstractThe method of variational completion allows one to transform an (in principle, arbitrary) system of partial differential equations – based on an intuitive “educated guess” – into the Euler–Lagrange one attached to a Lagrangian, by adding a canonical correction term. Here, we extend this technique to theories that involve at least two sets of dynamical variables: we show that an educated guess of the field equations with respect to one of these sets of variables only is sufficient to variationally complete these equations and recover a Lagrangian for the full theory, up to boundary terms and terms that do not involve the respective variables. Applying this idea to natural metric-affine theories of gravity, we prove that, starting from an educated guess of the metric equations only, one can find the full metric equations, together with a generally covariant Lagrangian, up to metric-independent terms. The latter terms (which can only involve the distortion of the connection) are then completely classified over 4-dimensional spacetimes, by techniques pertaining to differential invariants.
Gravitational lensing by transparent Janis–Newman–Winicour naked singularities
Authors: Chen Deyou , Chen Yiqian , Wang Peng , Wu Tianshu , Wu Houwen 
Published: June 2024

AbstractThe Janis–Newman–Winicour (JNW) spacetime can describe a naked singularity with a photon sphere that smoothly transforms into a Schwarzschild black hole. Our analysis reveals that photons, upon entering the photon sphere, converge to the singularity in a finite coordinate time. Furthermore, if the singularity is subjected to some regularization, these photons can traverse the regularized singularity. Subsequently, we investigate the gravitational lensing of distant sources and show that new images emerge within the critical curve formed by light rays escaping from the photon sphere. These newfound images offer a powerful tool for the detection and study of JNW naked singularities.