bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Effect of Spent Acid on Carbonate Rock Wettability
Authors: Saneifar Mehrnoosh 
Published: February 2010

Abstract
This is a study aimed at improving the efficiency of the matrix acidizing process, a well stimulation procedure applied to thousands of wells annually around the world. In these treatments, aqueous solutions of strong acid are injected into the formation. The injected water, which is referred to as spent acid after it reacts with the formation, will penetrate deeper into the formation beyond the stimulated zone. The spent acid needs to be easily removed so that the permeability to oil or gas can be restored. The time required for the cleanup of the spent acid from the formation depends on the formation permeability as well as the wettability and relative permeability characteristics.
An investigation of the possible changes in the wettability of the carbonate rock due to the invasion of spent acid and as a result of the additives added to the acid treatment showed that the carbonate rock by itself is relatively water wet and spent HCl does not change wettability of the rock. Experiments were further repeated with Zonly-8740, as a surface tension reducer additive and showed that Zonly-8740 changes wettability to gas wetting. A future plan is underway to investigate the effect of various additives and to study the long term effect on the wettability at reservoir conditions.
Effect of Prior Intensive Therapy in Type 1 Diabetes on 10-Year Progression of Retinopathy in the DCCT/EDIC: Comparison of Adults and Adolescents
Authors: White Neil H. , Sun Wanjie , Cleary Patricia A. , Tamborlane William V. , Danis Ronald P. , Hainsworth Dean P. , Davis Matthew D. ,   for the DCCT-EDIC Research Group
Published: February 2010

OBJECTIVE
The aim of this study was to examine differences between adolescents and adults in persistence of the benefits of intensive therapy 10 years after completion of the Diabetes Control and Complications Trial (DCCT).

RESEARCH DESIGN AND METHODS
During the Epidemiology of Diabetes Interventions and Complications (EDIC) study, progression of retinopathy from DCCT closeout to EDIC year 10 was evaluated in 1,055 adults and 156 adolescents.

RESULTS
During 10 years of follow-up, HbA1c (A1C) was similar between original intensive (INT) and conventional (CON) groups and between former adolescents and adults. At EDIC year 10, adults in the former INT group continued to show slower progression of diabetic retinopathy than those in the CON group (adjusted hazard reduction 56%, P &lt; 0.0001), whereas in adolescents this beneficial effect had disappeared (32%, P = 0.13). Seventy-nine percent of observed differences in the prolonged treatment effect between adults and adolescents at year 10 were explained by differences in mean A1C during DCCT between adolescents and adults (8.9 vs. 8.1%), particularly between INT adolescents and adults (8.1 vs. 7.2%).

CONCLUSIONS
Prior glycemic control during DCCT is vital for the persistence of the beneficial effects of INT therapy 10 years later. Lowering A1C to as close to normal as safely possible without severe hypoglycemia and starting as early as possible should be attempted for all subjects with type 1 diabetes. These results underscore the importance of maintaining A1C at target values for as long as possible because the benefits of former INT treatment wane over time if A1C levels rise.
Application of Fungal Waste Biomass Originating from Steroid Hormone Manufacture for Heavy Metals Removal
Authors: Paraszkiewicz Katarzyna , Felczak Aleksandra , Długoński Jerzy 
Published: February 2010

The biomass of Curvularia lunata, used previously for hydrocortisone production, was investigated as a heavy metal biosorbent. Removal of lead, zinc and cadmium ions was evaluated as a function of biosorbent dosages, initial ion concentrations, mode of mycelium modifications, initial pH of metal solutions and when these metals ions where presented in binary as well in ternary combinations. The results presented in this paper indicate the potential utility of C. lunata waste biomass for lead and, to a lower extent, for zinc and cadmium ions removal from acid solutions.
A Comparison of two Sphenoidotomy Approaches using a Novel Computerized Tomography grading System
Authors: Gheriani Heitham , Flamer David , Orton Trent , Mechor Brad , Javer Amin R. 
Published: February 2010

Background Endoscopic management of sphenoid sinus disease has great potential for surgical complications. A variety of endoscopic surgical techniques have been described for entering the sphenoid sinus. The utility of these surgical techniques is based on the position of the superior turbinate attachment to the sphenoid face (Parson's ridge). We introduce a novel computerized tomography (CT) grading system for the attachment of the superior turbinate to the sphenoid face. Using this new grading system, we recommend a safer systematic approach for entry into the sphenoid sinus. Methods A grading based on the attachment of the superior turbinate to the sphenoid face at the level of the natural sphenoid ostium was developed. A total of 53 patients were enrolled. Types A, B, and C refer to the superior turbinate attachment at the medial, middle, or lateral third of the anterior sphenoid face, respectively, and type D refers to orbital attachment of the superior turbinate. The surgical approach used (superior turbinate intact [STI] or superior turbinate resection [STR]) was recorded and correlated to the type of superior turbinate attachment. Results The overall incidence of the various superior turbinate attachments were 40% (41) for type A, 41% (42) for type B, 18% (19) for type C, and 1% (1) for type D. STR was used in 38 sides (44%) and STI was used in 48 sides (56%). Spearman correlation study showed that the closer the superior turbinate attachment was to the orbit the more likely STR was used as the choice of entry into the sphenoid (p < 0.001). Conclusion To perform a safe sphenoid entry it is pertinent to evaluate the superior turbinate attachment to the sphenoid face before making a decision on the method of entry.
Up-Regulation of Heparanase in the Ethmoid Sinus Mucosa of Patients with Chronic Sinusitis
Authors: Kim Tae Hoon , Lee Heung Man , Lee Seung Hoon , Choi Whan , Kim Ha Kyun , Lee Jung Hoon , Oh Kyoung Ho , Lee Sang Hag 
Published: February 2010

Background Heparanase (HPA) is known to be involved in tissue remodeling of various organs with inflammatory diseases. The aim of this study was to investigate the level of expression and the pattern of distribution of HPA in normal human sinus mucosa, inflammatory sinus mucosa, and nasal polyps to evaluate the possible effect of HPA on the tissue remodeling of chronic inflammatory sinus mucosa and nasal polyps. Methods Normal sinus mucosa was obtained from the ethmoid sinus during endoscopic reduction in 25 patients with blowout fractures. Inflammatory sinus mucosa and nasal polyps were obtained from 25 patients undergoing endoscopic sinus surgery for chronic sinusitis with nasal polyps. The levels of expression and the pattern of distribution of HPA were evaluated in normal human sinus mucosa, inflammatory sinus mucosa, and nasal polyps, using reverse transcriptase-polymerase chain reaction, immunohistochemical analysis, and Western blot analysis. Results HPA mRNA and protein were detected in inflammatory sinus mucosa and nasal polyps but not in normal sinus mucosa. HPA was mainly localized in the vascular endothelium, epithelium, submucosal glands, and inflammatory cells of inflammatory sinus mucosa. In nasal polyps, inflammatory cells and vascular endothelium showed immunopositivity in the entire portion, whereas glands and epithelial cells did not show positivity. Conclusion Our results indicate that HPA is not constitutively expressed in normal sinus mucosa and is upregulated in chronic inflammatory sinus mucosa and nasal polyps, suggesting that HPA may play an important role in the tissue remodeling in chronic sinusitis.
Endoscopic Endonasal Repair of Difficult-To-Access Cerebrospinal Fluid Leaks of the Frontal Sinus
Authors: Becker Samuel S. , Duncavage James A. , Russell Paul T. 
Published: February 2010

Background Cerebrospinal fluid (CSF) leaks located within the frontal sinus can be difficult to repair effectively. Additional challenges arise from the need to simultaneously repair the leak or defect and to ensure the future patency of the sinus itself. Methods The cases of two patients who underwent surgical repair of CSF leaks and skull base defects located in difficult to access locations within their frontal sinuses were reviewed. Results Two patients with CSF leaks in the frontal sinus underwent surgery to repair the leaks. The leaks were in the superomedial and superolateral locations within the sinus. One leak (in the superolateral location) was secondary to iatrogenic surgical trauma during craniotomy. The second leak (in the superomedial location) was secondary to congenital encephalocele. Surgical approach to ensure adequate exposure was via endoscopic modified Lothrop procedure. Successful repair was undertaken via underlay technique. At follow-up (27 and 7 months, respectively), frontal sinuses remained patent without evidence of CSF leak. Conclusion CSF leaks located in medial and lateral areas of the frontal sinus may be successfully repaired via endonasal approach with endoscopic modified Lothrop. Repair in this manner requires that attention be paid both to achieving a complete repair and to maintaining a patent sinus drainage pathway.
Endoscopic Ligation of the Sphenopalatine Artery and the Maxillary Artery for the Treatment of Intractable Posterior Epistaxis
Authors: Seno Satoshi , Arikata Masahiko , Sakurai Hironori , Owaki Shigehiro , Fukui Jun , Suzuki Mikio , Shimizu Takeshi 
Published: February 2010

Background Intractable posterior epistaxis sometimes requires intensive treatment, such as surgery or embolization. Maxillary artery ligation has been widely used for the treatment of intractable posterior epistaxis. It is highly effective, but significant complications may occur, including an oroantral fistula and damage to the infraorbital nerve. Embolization is less invasive and can be performed in poor surgical candidates. However, it has more serious complications, such as facial nerve paralysis and hemiplegia. This investigation evaluates the effectiveness and complications of endoscopic ligation of the sphenopalatine or maxillary artery for the treatment of intractable posterior epistaxis. Methods Between April 2003 and March 2007, 46 patients were hospitalized for the treatment of severe posterior epistaxis in our University Hospital. Thirty patients were successfully treated by anterior and/or posterior nasal packing, and five patients were treated by electrocoagulation. Endoscopic ligation was performed under general anesthesia in 11 patients (6 men and 5 women; age range, 50-80 years). Results Eight patients underwent endoscopic ligation of the sphenopalatine artery, and three patients underwent endoscopic ligation of the maxillary artery through the middle meatus and posterior antral wall opening. There were no complications, and the patients’ postoperative courses were uneventful. Recurrent epistaxis occurred in one patient on oral anticoagulants 15 months after ligation of the sphenopalatine artery, and it was successfully treated by anterior nasal packing. Conclusion Endoscopic ligation of the sphenopalatine or maxillary artery is safer than arterial embolization and is less invasive than transantral ligation of the maxillary artery. This technique appears to be a simple and highly effective surgical treatment for patients with intractable posterior epistaxis.
Minitrephination of the Frontal Sinus: Indications and uses in Today's Era of Sinus Surgery
Authors: Seiberling Kristin , Jardeleza Camille , Wormald Peter-John 
Published: February 2010

Background This study reviews the role of frontal sinus minitrephination in today's era of endoscopic sinus surgery. Retrospective chart review was performed of 163 patients undergoing a total of 149 bilateral and 39 unilateral frontal sinus minitrephinations. Methods Charts were reviewed for patient demographics and outcomes. Details obtained from the chart included type of surgery performed, reason for minitrephine placement, pathology, Lund score, complications, and endoscopic patency. Results One hundred eighty-eight minitrephines were placed during 80 modified Lothrop and 108 frontal sinusotomies. Trephines were placed when there was difficulty finding the frontal recess, severe edema/polyps, obstructing frontal cells (type 3/type 4 frontoethmoidal cells and intersinus septum cell), and to aid the dissection and postoperative irrigation during the modified Lothrop. Twelve complications occurred with infection at the trephine site being the most common. Follow-up ranged from 2 to 122 months (average, 25.5 months) with 92% showing endoscopic patency at last visit. Conclusion Frontal sinus trephination is a safe useful procedure that can be extremely helpful in identifying the pathway to the frontal sinus. Fluorescein flushes through the trephine help guide the dissection in a modified Lothrop. Lastly, it may be used in the postoperative period to flush the sinus with saline and steroids to promote patency of the frontal sinus.
Do Single-Photon Emission Computerized Tomography Findings Predict Severity of Chronic Rhinosinusitis: A Pilot Study
Authors: Saylam Güleser , Gorgülü Orhan , Korkmaz Hakan , Dursun Engin , Ortapamuk Hülya , Eryilmaz Adil 
Published: February 2010

Background Chronic rhinosinusitis (CRS) is basically an inflammatory disease of the mucosa and periosteum of the sinuses. The possibility of local osteitis can cause persistent mucosal inflammation and lead to failure of treatment. Bone scintigraphy is the gold standard procedure for detecting the bone involvement. This study was designed to evaluate whether single-photon emission computerized tomography (SPECT) findings predict severity of chronic sinusitis and subjective response to medical treatment. A prospective case control study was done. Methods Twenty-four patients with CRS were involved. SPECT findings for bone involvement and computed tomography-based staging (limited disease, stage 1; extensive disease, stages 2 and 3) were compared. These data were also analyzed in terms of subjective response to medical treatment and prognosis. Results SPECT uptakes were positive in 79.2% (19/24) and negative in 20.8% (5/24) of the patients. SPECT was positive in 4/8 of the patients with limited disease and 15/16 of the patients with extensive disease. In subjective assessment of medical treatment 5/8 of the limited disease versus 1/16 the extensive disease patients had good response; whereas 5/5 of SPECT− patients versus 1/19 of SPECT+ patients had good response. Conclusion Bone SPECT results were found to be correlated with the stage of CRS. Poorer subjective response was observed in patients with positive SPECT.
Contribution of Nasal Biopsy to Leprosy Diagnosis
Authors: Naves Marcell Melo , Patrocinio Lucas Gomes , Patrocinio José Antonio , Naves Mota Flávia Marques , De Souza Antônio Diniz , Fleury Raul Negrão , Bernardes Goulart Isabela Maria 
Published: February 2010

Background The nasal mucosa plays the main role as the entry and the exit of leprosy bacilli and the nasal involvement may precede the skin lesions by several years. Nasal biopsy has been used in research but its clinical application has not been described. We evaluated the contribution of the nasal biopsy for the diagnosis of leprosy and its correlation to skin biopsy and skin smear in untreated patients. Methods We evaluated changes in nasal biopsy in 227 leprosy patients. Patients were clinically classified and skin and nasal biopsies and skin smear were performed. Results Nasal biopsy showed positivity in 100% of the lepromatous spectrum decreasing toward the tuberculoid (TT) pole. Patients with TT or indeterminate forms did not present any nasal alterations, showing that they are the true paucibacillary forms. Also, the nasal biopsies of two patients were the only exam to show positivity. The bacillary index of the nasal biopsy was strongly correlated to skin biopsy and slit-skin smear. Additionally, the agreement among the exams was good, revealing the reliability of the nasal biopsy in leprosy diagnosis. Conclusion The present study showed a rate of 48% of positivity in nasal biopsy of untreated patients, correlating well with skin biopsy and skin smear. Thus, the method in leprosy diagnosis and clinical form classification has shown great reliability.
Influence of the Turbinate Volumes as Measured by Magnetic Resonance Imaging on Nasal Air Conditioning
Authors: Lindemann Joerg , Tsakiropoulou Evangelia , Vital Victor , Keck Tilman , Leiacker Richard , Pauls Sandra , Wacke Florian , Wiesmiller Kerstin M. 
Published: February 2010

Background Changes in nasal airflow caused by varying intranasal volumes and cross-sectional areas affect the contact between air and surrounding mucosa entailing alterations in nasal air conditioning. This study evaluates the correlation between nasal air conditioning and the volumes of the inferior and middle turbinates as measured by magnetic resonance imaging (MRI). Methods Fourteen healthy volunteers were enrolled. Each volunteer had been examined by rhinomanometry, acoustic rhinometry, intranasal air temperature, and humidity measurements at defined intranasal sites as well as MRI of the nasal cavity and the paranasal sinuses. The volumetric data of the turbinates was based on the volumetric software Amira. Results Comparable results were obtained regarding absolute humidity values and temperature values within the nasal valve area and middle turbinate area for both the right and the left side of the nasal cavity. No statistically significant differences were found in the rhinomanometric values and the acoustic rhinometry results of both sides (p > 0.05). No statistical correlations were found between the volumes of the inferior (mean, 6.1 cm3) and middle turbinate (mean, 1.8 cm3) and the corresponding humidity and temperature values. Additionally, the air temperature and humidity values did not correlate with the rhinometrical endonasal volumes (0–20 mm and 20–50 mm from the nasal entrance). Conclusion The normal range of volumes of the inferior and middle turbinate does not seem to have a significant impact on intranasal air conditioning in healthy subjects. The exact limits where alterations of the turbinate volume negatively affect nasal air conditioning are still unknown.
Current Management of Juvenile Nasopharyngeal Angiofibroma: A Tertiary Center Experience 1999–2007
Authors: Bleier Benjamin S. , Kennedy David W. , Palmer James N. , Chiu Alexander G. , Bloom Jason D. , O'Malley Bert W. 
Published: February 2010

Background Over the past 10 years, the management of juvenile nasopharyngeal angiofibroma (JNA) has been redefined because of the improvement of transnasal skull base techniques. However, the limits of endoscopic resection still have to be fully defined. The purpose of this study was to report on a series of patients presenting with JNA in an effort to further define an optimal treatment algorithm and improve outcomes. Methods A retrospective review was performed of 18 patients presenting to a tertiary care institution with JNA from 1999 to 2007. Patients were categorized by Andrews stage and data were collected on presentation, operative technique, and postoperative course. Results All patients underwent preoperative embolization. Stages 1, 2, and one 3a lesions were approached endoscopically while the remainder underwent open resection. In the endoscopic group the intraoperative blood loss was almost half that of the open group (506 versus 934 mL) and the average hospital stay was 1 day less (3 vs. 4 days). Conclusion Endoscopic resection is reasonable for Andrews stage 1, 2, and select 3a lesions and may allow for less bleeding and a shorter hospital stay. This study supports the current trend of expansion of indications for endoscopic JNA resection.
Indications for External Frontal Sinus Procedures for Inflammatory Sinus Disease
Authors: Hahn Samuel , Palmer James N. , Purkey Michael T. , Kennedy David W. , Chiu Alexander G. 
Published: February 2010

Background In the modern age of endoscopic sinus surgery (ESS), there is an undefined role for external approaches in the treatment of inflammatory disease. This study examines the frontal sinus surgery practices of three experienced rhinologists with a focus on those who underwent an external approach. Our goal was to characterize these patients and propose indications for the use of an external approach alone or in combination with functional ESS (FESS) for frontal sinus inflammatory disease. Methods A retrospective review was performed of frontal sinus procedures performed for inflammatory disease at one institution from 2004 to 2007. Results Seven hundred seventeen procedures were performed, 38 (5.3%) of which were external alone (14 procedures) or in combination with FESS (24 procedures). Osteoplastic flap with obliteration (12/14) made up the majority of external alone procedures and the most common indication was neo-osteogenesis of the frontal recess. Trephination was the most common external adjunct to FESS (12/24), and often was performed for type 3 frontal recess cells or in the initial management of acute frontal bone osteomyelitis (FOM). Twenty-eight of 38 (74%) patients had a history of previous surgery. Of the 10 patients with no history of previous surgery, 6 (60%) had an external adjunct for frontal recess neo-osteogenesis. There were no major complications but 9/38 (23.7%) patients required revision surgery for persistent/recurrent symptoms. Conclusion External approaches alone and in combination with FESS are predominantly secondary to neo-osteogenesis of the frontal recess. Factors associated with neo-osteogenesis include previous trauma, endoscopic surgery, and FOM. External frontal sinus surgery provides adequate management of inflammatory disease but has a high revision rate.
Efficacy of Targeted Medical Therapy in Chronic Rhinosinusitis, and Predictors of Failure
Authors: Lal Devyani , Scianna Joseph M. , Stankiewicz James A. 
Published: February 2010

Background No standardized medical therapy for chronic rhinosinusitis (CRS) is universally accepted. Success of medical therapy is reportedly 50% to 88%, but studies differ in inclusion criteria, medications, duration of therapy, and defining “success.” The objectives of this study were to determine efficacy of a standardized targeted medical therapy (TMT) regimen in CRS and to analyze factors associated with failure of therapy. Methods Retrospective analysis of prospectively collected data was performed. CRS was diagnosed based on CRS Taskforce guidelines. TMT was defined as a minimum 4-week treatment with oral antibiotics, oral steroids, topical nasal steroids, topical nasal decongestant rotation, and saline nasal douching. “Failure” was defined as relapse/persistence of signs/symptoms or need for surgery. One hundred forty-five patients that received TMT, with a minimum 2-month follow-up, were identified. The results of therapy were reviewed to determine efficacy and analyze factors associated with failure. Results Seventy-four patients (51.03%) were successfully treated. Failures included 26 patients (17.8%) with only partial improvement and 45 (31.03%) who underwent surgery. Only history of facial pressure/pain (p = 0.049), presence of mucosal inflammation (p = 0.013), and higher endoscopic severity grade (p = 0.011) were associated with failure of TMT. Conclusions TMT was unequivocally successful in 51% of patients. Failures included 31% who underwent surgery and 18% with partial benefit. Surgery was avoided in 69%. Facial pressure/pain, mucosal inflammation, and higher endoscopic severity grade were associated with failure of medical therapy.