bluuebunny/crossref_metadata_2025_split huggingface dataset:
Enabling high‐speed asynchronous data extraction and transfer using DART
Authors: Docan Ciprian , Parashar Manish , Klasky Scott 
Published: March 2010

AbstractAs the complexity and scale of applications grow, managing and transporting the large amounts of data they generate are quickly becoming a significant challenge. Moreover, the interactive and real‐time nature of emerging applications, as well as their increasing runtime, make online data extraction and analysis a key requirement in addition to traditional data I/O and archiving. To be effective, online data extraction and transfer should impose minimal additional synchronization requirements, should have minimal impact on the computational performance and communication latencies, maintain overall quality of service, and ensure that no data is lost. In this paper we present Decoupled and Asynchronous Remote Transfers (DART), an efficient data transfer substrate that effectively addresses these requirements. DART is a thin software layer built on RDMA technology to enable fast, low‐overhead, and asynchronous access to data from a running simulation, and supports high‐throughput, low‐latency data transfers. DART has been integrated with applications simulating fusion plasma in a Tokamak, being developed at the Center for Plasma Edge Simulation (CPES), a DoE Office of Fusion Energy Science (OFES) Fusion Simulation Project (FSP). A performance evaluation using the Gyrokinetic Toroidal Code and XGC‐1 particle‐in‐cell‐based FSP simulations running on the Cray XT3/XT4 system at Oak Ridge National Laboratory demonstrates how DART can effectively and efficiently offload simulation data to local service and remote analysis nodes, with minimal overheads on the simulation itself. Copyright © 2010 John Wiley & Sons, Ltd.
SCCS: Spatiotemporal clustering and compressing schemes for efficient data collection applications in WSNs
Authors: Pham Ngoc Duy , Le Trong Duc , Park Kwangjin , Choo Hyunseung 
Published: March 2010

AbstractThe development of large‐scale wireless sensor networks engenders many challenging problems. Examples of such problems include how to dynamically organize the sensor nodes into clusters and how to compress and route the sensing information to a remote base station. Sensed data in sensor systems reflect the spatial and temporal correlations of physical attributes existing intrinsically in the environment. Noteworthy efficient clustering schemes and data compressing techniques proposed recently leverage the spatiotemporal correlation. These include the framework of Liuet al.and schemes introduced by Gediket al.However, the previous clustering schemes are based on an impractical assumption of a single‐hop network architecture and their cluster construction communication cost is relatively expensive. On the other hand, the computational overhead of recent compressing techniques (e.g. the work of Liuet al.and Douglaset al.) is quite significant; therefore, it is hard for sensor nodes with limited processing capability to perform these techniques. With such motivation, we propose a novel and one‐round distributed clustering scheme based on spatial correlation between sensor nodes, and propose a novel light‐weight compressing algorithm to effectively save the energy at each transmission from sensors to the base station based on temporal correlation of the sensed data. Besides, the aim of the proposed clustering scheme is not only to group the nodes with the highest similarity in observations into the same cluster, but also to construct and maintain a dynamic backbone for efficient data collection in the networks (with the consideration of sink mobility). Computer simulation shows that the proposed schemes significantly reduce the overall number of communications in the cluster construction phase and the energy consumed in each transmission, while maintaining a low variance between the readings of sensor nodes in the same clusters and high reliability of the compressed data. Copyright © 2010 John Wiley & Sons, Ltd.
Distributed spatial–temporal precoding with limited feedback in MIMO multi‐relay systems
Authors: Long Hang , Zheng Kan , Wang Fangxiang , Wang Wenbo 
Published: March 2010

AbstractPrecoding techniques can be introduced into multi‐relay systems due to the similarity between cooperative communication systems and traditional multi‐input–multi‐output (MIMO) systems. In this paper, a channel state information (CSI) feedback scheme based on the zero‐forcing (ZF) relaying protocol is proposed at first, where the information of relaying channel and noise related to each relay node can be compressed into two positive real parameters. Then, based on the proposed feedback scheme, the singular‐vector‐based local temporal precoder is presented at the source node through two continuous transmitted vectors, which is termed as distributed spatial–temporal precoding (DSTP). Moreover, various spatial data rates can be conveniently supported by DSTP. Based on the analysis on DSTP, it is better that the number of data streams is not larger than the number of antennas equipped at the source node. The unitary DSTP with the proposed feedback scheme outperforms not only the close‐loop direct transmission but also the simple ZF relaying method. Copyright © 2010 John Wiley & Sons, Ltd.
Performance–lifetime tradeoff for source extraction in multihop sensor networks
Authors: Chen Hongbin , Feng Jiuchao , Tse Chi K. 
Published: March 2010

AbstractThis paper intends to reveal the performance–lifetime tradeoff for source extraction in a multihop sensor network. The randomly deployed sensor network consists of multiple independent branches. The leaf node in each branch takes an observation from the sensing field. The observation is assumed to be a noisy instantaneous linear mixture of the sources. To account for the bandwidth constraint, each leaf node quantizes its observation and sends the quantized data to the sink in a multihop fashion. The observed mixtures are reconstructed at the sink and are utilized to extract the sources. The accumulated bit error probability in each branch depends on the number of hops and the bit error probability of each channel in that branch. The communication errors affect the accuracy of reconstructing mixtures, and hence affect the performance of source extraction. Network lifetime is defined and analyzed under both per‐sensor energy constraint and network energy constraint. The tradeoff between performance and network lifetime is described by optimization problems and the conditions for optimization are identified. As a by‐product, the conditions for maximizing the network lifetime are also identified. Simulation results demonstrate that the tradeoff exists under certain situations. Copyright © 2010 John Wiley & Sons, Ltd.
Spatio‐temporal dynamics of gene expression of the Edn1‐Dlx5/6 pathway during development of the lower jaw
Authors: Vieux‐Rochas Maxence , Mantero Stefano , Heude Eglantine , Barbieri Ottavia , Astigiano Simonetta , Couly Gérard , Kurihara Hiroki , Levi Giovanni , Merlo Giorgio R. 
Published: March 2010

AbstractThe morphogenesis of the vertebrate skull results from highly dynamic integrated processes involving the exchange of signals between the ectoderm, the endoderm, and cephalic neural crest cells (CNCCs). Before migration CNCCs are not committed to form any specific skull element, molecular signals exchanged in restricted regions of tissue interaction are crucial in providing positional identity to the CNCCs mesenchyme and activate the specific morphogenetic process of different skeletal components of the head. In particular, the endothelin‐1 (Edn1)‐dependent activation of Dlx5 and Dlx6 in CNCCs that colonize the first pharyngeal arch (PA1) is necessary and sufficient to specify maxillo‐mandibular identity. Here, to better analyze the spatio‐temporal dynamics of this process, we associate quantitative gene expression analysis with detailed examination of skeletal phenotypes resulting from combined allelic reduction of Edn1, Dlx5, and Dlx6. We show that Edn1‐dependent and ‐independent regulatory pathways act at different developmental times in distinct regions of PA1. The Edn1→Dlx5/6→Hand2 pathway is already active at E9.5 during early stages of CNCCs colonization. At later stages (E10.5) the scenario is more complex: we propose a model in which PA1 is subdivided into four adjacent territories in which distinct regulations are taking place. This new developmental model may provide a conceptual framework to interpret the craniofacial malformations present in several mouse mutants and in human first arch syndromes. More in general, our findings emphasize the importance of quantitative gene expression in the fine control of morphogenetic events. genesis 48:362–373, 2010. © 2010 Wiley‐Liss, Inc.
Predicting reading and spelling difficulties in transparent and opaque orthographies: a comparison between Scandinavian and US/Australian children
Authors: Furnes Bjarte , Samuelsson Stefan 
Published: March 2010

AbstractIn this study, predictors of reading and spelling difficulties among children learning more transparent (Norwegian/Swedish) and less transparent (English) orthographies were examined longitudinally from preschool through Grade 2 using parallel versions of tests. A series of logistic regression analysis indicated three main findings. First, phonological awareness as a predictor of reading difficulties in the Scandinavian sample was time‐limited to Grade 1, but remained as a significant predictor in the English‐speaking sample. Second, phonological awareness predicted spelling difficulties similarly across orthographies. Third, preschool and kindergarten RAN was a significant predictor of reading and spelling difficulties at both Grades 1 and 2 across orthographies. The authors conclude that phonological awareness diminishes as a predictor of reading difficulties in transparent orthographies after the first years of schooling, that RAN is a better long‐term predictor of reading difficulties, and that phonological awareness is associated with spelling difficulties similarly in transparent and opaque orthographies. Copyright © 2010 John Wiley & Sons, Ltd.
The MyD88 protein 88 pathway is differently involved in immune responses induced by distinct substrains of Leishmania major
Authors: Revaz‐Breton Mélanie , Ronet Catherine , Ives Annette , Torre Yazmin Hauyon‐La , Masina Slavica , Tacchini‐Cottier Fabienne , Launois Pascal 
Published: March 2010

AbstractHost resistance to Leishmania major is highly dependent on the development of a Th1 immune response. The TLR adaptator myeloid differentiation protein 88 (MyD88) has been implicated in the Th1 immune response associated with the resistant phenotype observed in C57BL/6 mice after infection with L. major. To investigate whether the MyD88 pathway is differentially used by distinct substrains of parasites, MyD88−/− C57BL/6 mice were infected with two substrains of L. major, namely L. major LV39 and L. major IR75. MyD88−/− mice were susceptible to both substrains of L. major, although with different kinetics of infection. The mechanisms involved during the immune response associated with susceptibility of MyD88−/− mice to L. major is however, parasite substrain‐dependent. Susceptibility of MyD88−/− mice infected with L. major IR75 is a consequence of Th2 immune‐deviation, whereas susceptibility of MyD88−/− mice to infection with L. major LV39 resulted from an impaired Th1 response. Depletion of regulatory T cells (Treg) partially restored IFN‐γ secretion and the Th1 immune response in MyD88−/− mice infected with L. major LV39, demonstrating a role of Treg activity in the development of an impaired Th1 response in these mice.
Efficient and versatile manipulation of the peripheral CD4+ T‐cell compartment by antigen targeting to DNGR‐1/CLEC9A
Authors: Joffre Olivier P. , Sancho David , Zelenay Santiago , Keller Anna M. , Reis e Sousa Caetano 
Published: March 2010

AbstractDC NK lectin group receptor‐1 (DNGR‐1, also known as CLEC9A) is a C‐type lectin receptor expressed by mouse CD8α+ DC and by their putative equivalents in human. DNGR‐1 senses necrosis and regulates CD8+ T‐cell cross‐priming to dead‐cell‐associated antigens. In addition, DNGR‐1 is a target for selective in vivo delivery of antigens to DC and the induction of CD8+ T‐cell and Ab responses. In this study, we evaluated whether DNGR‐1 targeting can be additionally used to manipulate antigen‐specific CD4+ T lymphocytes. Injection of small amounts of antigen‐coupled anti‐DNGR‐1 mAb into mice promoted MHC class II antigen presentation selectively by CD8α+ DC. In the steady state, this was sufficient to induce proliferation of antigen‐specific naïve CD4+ T cells and to drive their differentiation into Foxp3+ regulatory lymphocytes. Co‐administration of adjuvants prevented this induction of tolerance and promoted immunity. Notably, distinct adjuvants allowed qualitative modulation of CD4+ T‐cell behavior: poly I:C induced a strong IL‐12‐independent Th1 response, whereas curdlan led to the priming of Th17 cells. Thus, antigen targeting to DNGR‐1 is a versatile approach for inducing functionally distinct CD4+ T‐cell responses. Given the restricted pattern of expression of DNGR‐1 across species, this strategy could prove useful for developing immunotherapy protocols in humans.
Synthesis, Structures, and Magnetic Properties of N‐Trialkylsilyl‐8‐amidoquinoline Complexes of Chromium, Manganese, Iron, and Cobalt as well as of Wheel‐Like Hexanuclear Iron(II) and Manganese(II) Bis(8‐amidoquinoline)
Authors: Malassa Astrid , Agthe Christine , Görls Helmar , Podewitz Maren , Yu Lian , Herrmann Carmen , Reiher Markus , Westerhausen Matthias 
Published: March 2010

AbstractThe transamination of 8‐(tert‐butyldimethylsilylamino)quinoline with (thf)2Cr[N(SiMe3)2]2 yields monomeric bis[8‐(tert‐butyldimethylsilylamido)quinoline]chromium(II) (1). Similar reactions of M[N(SiMe3)2]2 (M = Mn, Fe, Co) with 8‐(trialkylsilylamino)quinoline lead to the formation of monomeric bis[8‐(trialkylsilylamido)quinoline]metal(II) [M = Mn, SiR3 = SiMe2tBu (2a), SiiPr3 (2b); M = Fe, SiR3 = SiMe2tBu (3a),SiiPr3 (3b); M = Co, SiR3 = SiMe2tBu (4a), SiiPr3 (4b)]. The transamination of 8‐aminoquinoline with M[N(SiMe3)2]2 (M = Mn, Fe, Co) allows the isolation of the heteroleptic 1:1 and homoleptic 2:1 products. The 1:1 complexes bis[8‐amidoquinoline metal(II)bis(trimethylsilyl)amide] [M = Mn (5), Fe (6), Co (7)] are dimeric with bridging 8‐amidoquinoline moieties. The 2:1 complexes of Mn and Fe, bis(8‐amidoquinoline)manganese(II) (8) and bis(8‐amidoquinoline)iron(II) (9), form hexamers with wheel‐like molecular structures consisting of metal‐centered nitrogen octahedra interconnected by common N···N edges. The cobalt complex, bis(8‐amidoquinoline)cobalt(II) (10), precipitates as a microcrystalline powder. Investigations of the magnetic properties by DFT corroborate the experimental data for the Mn derivative 8, where an antiferomagnetic coupling is observed. By contrast, calculations on the Fe6‐wheel 9 yield very close‐lying ferromagnetically and antiferromagnetically coupled states.
f,f Homodinuclear and d,f or f,f′ Heterodinuclear Complexes with a [2+2] Macrocyclic Compartmental Schiff Base
Authors: Tamburini Sergio , Peruzzo Valentina , Benetollo Franco , Vigato P. Alessandro 
Published: March 2010

AbstractThe [2+2] compartmental macrocyclic complexes [Ln(H2‐L)(NO3)], where H2‐L is the cyclic Schiff base, derived from the condensation of 2,6‐diformyl‐4‐chlorophenol (H‐LA) or 2,6‐diformyl‐4‐methylphenol (H‐LB) and N,N‐bis(2‐aminoethyl)‐2‐hydroxybenzylamine·3HCl (HA′·3HCl), contains a free N3O3 coordination chamber and can act as a ligand toward an identical or a different lanthanide(III) ion and a d transition metal(II) ion to give the related f,f homodinuclear [Ln2(L)(X)2] and f,f′ heterodinuclear [LnLn′(L)(X)2] or d,f heterodinuclear [LnM(L)(X)] complexes. They have been characterized by ESEM‐EDS, ESI‐MS, and IR and 1H and 13C NMR spectroscopy. The X‐ray single‐crystal analysis of the [2+1] acyclic complex [Lu2(L′)2], derived from partial hydrolysis of the related [2+2] homodinuclear complex [Lu2(L)(Cl)2], followed by the loss of one lutetium(III) ion with the free formyl groups turning into diacetal ones, is also reported.
Photocontrolled Molecular Assembler Based on Cucurbit[8]uril: [2+2]‐Autophotocycloaddition of Styryl Dyes in the Solid State and in Water
Authors: Gromov Sergey P. , Vedernikov Artem I. , Kuz'mina Lyudmila G. , Kondratuk Dmitry V. , Sazonov Sergey K. , Strelenko Yuri A. , Alfimov Michael V. , Howard Judith A. K. 
Published: March 2010

AbstractThree styryl dyes of the 4‐pyridine series that form syn‐head‐to‐tail dimeric pairs in polycrystalline films were synthesised. NMR and UV/Vis spectroscopic studies showed that this promotes stereospecific [2+2]‐autophotocycloaddition (PCA) in the dimeric pairs to give rctt‐isomers of cyclobutane derivatives. For the dye with an N‐ammoniopropyl substituent, this transformation was accomplished according to the single‐crystal‐to‐single‐crystal pattern. In aqueous solutions, the dyes and cucurbit[n]urils (CB[n], n = 7, 8) form complexes with a pseudorotaxane structure. CB[7] tends to form 1:1 complexes, and CB[8] forms 1:1 and 2:1 complexes. The structure of the termolecular complex formed by the betaine of the N‐sulfonatopropyl styryl dye and CB[8] was determined by X‐ray diffraction. The stability of the complexes was measured by 1H NMR titration in a D2O/[D3]MeCN (10:1) mixture (log K1:1 ≥ 3.2, log K2:1 ≥ 2.6). Free dyes and their complexes with CB[7] in water undergo only (E)/(Z) photoisomerisation. Termolecular complexes of all dyes with CB[8] were found to undergo effective stereospecific PCA reactions to give rctt isomers of cyclobutane derivatives. The 1:1 complexes of the obtained cyclobutanes with CB[8] (log Kcb = 3.2–4.8) are less stable than those of the starting dyes with the same stoichiometry. Thus, CB[8] can play the role of a photocontrolled molecular assembler, i.e., even in the presence of 5 mol‐% of CB[8], complete conversion of styryl dyes into the corresponding cyclobutane derivatives takes place upon irradiation in solution.
About the Inhibition of Grignard Reagent Formation by p‐Dinitrobenzene: Comparing the Mechanism of Grignard Reagent Formation and the SRN1 Mechanism
Authors: Bodineau Nicolas , Mattalia Jean‐Marc , Hazimeh Hassan , Handoo Kishan L. , Timokhin Vitaliy , Négrel Jean‐Claude , Chanon Michel 
Published: March 2010

AbstractBoth SRN1‐type reactions and Grignard reagent formation are inhibited by trace amounts (with respect to the halide) of p‐dinitrobenzene (DNB) and other oxidising agents such as CuCl2 or dioxygen. Both are believed to be triggered by an electron‐transfer step. In this report we examine the patterns of reactivity shared by these two types of reaction. Although the two reactions display an amazing number of similarities, the chain character of the Grignard reaction mechanism has been rejected by major contributors to this field. We have performed new experiments to explore the inhibiting effect associated with the addition of trace amounts of p‐dinitrobenzene during Grignard reagent formation. This inhibition involves very reactive nanoparticles of magnesium prepared by metal vapour synthesis. The magnesium slurries studied, in the absence of p‐dinitrobenzene, display no induction period at all. If the p‐dinitrobenzene is added to the solution containing magnesium slurries 25 min before adding the organic halide (here bromobenzene), the reaction is neatly inhibited but, if one waits long enough, the Grignard reagent is nevertheless formed. If, however, the same trace amounts of p‐dinitrobenzene are diluted in the organic halide and this mixture is added to the magnesium slurries, the inhibiting effect is far less pronounced. The addition of the nBu4NBr salt drastically diminishes the inhibiting power of DNB. These observations, in addition to the ESR study of radical anions formed in THF by the reaction of magnesium nanoparticles and DNB with various polyaromatics, suggest a mechanism for the observed inhibitions that involves a series of reversible adsorptions of the present species. This adsorption would depend on both thermodynamic and kinetic factors. Thermodynamics would favour the adsorption of DNB radical anions but C–X bond cleavage of the less strongly adsorbed aromatic radical anions would provide a kinetic driving force for displacing the equilibria in the direction of Grignard reagent formation. Salt effects could operate by displacing the equilibrium – adsorbed DNB radical anion or dianion versus solvated radical anion (with the counterion nBu4N+) – to the right, accelerating therefore the liberation of active sites on the magnesium surface. It appears that the inhibiting effect of the same compound finds its origin in two different molecular series of events in SRN1 and in Grignard reagent formation. The heterogeneous character of the Grignard reagent makes it possible to envision the possibility of active sites even on nanoparticles, whereas the inhibition of the SRN1 mechanism by DNB occurs in homogeneous solution.
The 3‐Hydroxypiperidine Skeleton: Key Element in Natural Product Synthesis
Authors: Wijdeven Marloes A. , Willemsen Jorgen , Rutjes Floris P. J. T. 
Published: March 2010

AbstractThe 3‐hydroxypiperidine moiety is a privileged scaffold that is encountered in many bioactive compounds and natural products. This review summarizes the investigations ofvarious research groups concerning the synthesis of natural products containing this scaffold.
Synthesis, Optical Properties, and Crystal Structure of 1,4‐Dipropyltetracene
Authors: Kitamura Chitoshi , Matsumoto Chika , Yoneda Akio , Kobayashi Takashi , Naito Hiroyoshi , Komatsu Toshiki 
Published: March 2010

AbstractWe synthesized 1,4‐dipropyltetracene on a 200‐mg scale, the key step of which involved a Diels–Alder reaction between alkyl‐substituted o‐quinodimethane, generated in situ, and 1,4‐naphthoquinone. The product was obtained as an orange solid, which was soluble in organic solvents including hexane. The optical properties of the product in solution showed no marked differences from those of other 1,4,7,10‐tetraalkyltetracenes. Solid‐state absorption and fluorescence spectra exhibited 20–30 nm blueshifts compared with those of 1,4,7,10‐tetrapropyltetracene. X‐ray analysis revealed that two propyl groups were coplanar with the tetracene ring, that there was no π overlap along the stacking direction, and that the molecules formed a herringbone structure. The peripheral alkyl chains were found to be important for controlling the molecular packing and optical properties in the solid state.
Functionalization of Mono‐ and Oligonucleotides with Phosphane Ligands by Amide Bond Formation
Authors: Nuzzolo Marzia , Grabulosa Arnald , Slawin Alexandra M. Z. , Meeuwenoord Nico J. , van der Marel Gijsbert A. , Kamer Paul C. J. 
Published: March 2010

AbstractSeven phosphane‐functionalized deoxyuridines have been prepared by amide bond formation between aminodeoxyuridines and phosphanylcarboxylic acids. X‐ray crystal structures for two of these new modified nucleosides have been obtained. The same coupling method has been extended to oligonucleotides. The phosphane containing strands have been purified and characterized by MALDI‐TOF and, for the first time, 31P NMR spectrometry. Coordination of a phosphane‐modified 15‐mer to a [PdCl(η3‐allyl)] moiety has been confirmed by 31P NMR spectroscopy.
NiII–(σ‐Aryl) Complex Catalyzed Suzuki Reaction of Aryl Tosylates with Arylboronic Acids
Authors: Fan Xin‐Heng , Yang Lian‐Ming 
Published: March 2010

AbstractA practical, efficient protocol was developed for the Suzuki reaction of aryl tosylates with arylboronic acids. The process was promoted by a nickel‐based catalyst system consisting of the easily available NiII–(σ‐aryl) complex and the simple ligand PPh3 in toluene in the presence of the base K2CO3. The convenient operation, high yield, generality, and low cost make this method viable for most common laboratories and applicable in large‐scale preparations.