bluuebunny/crossref_metadata_2025_split huggingface dataset:
Objective factors affecting overall subjective evaluation of recovery after anterior cruciate ligament reconstruction
Authors: Muneta T. , Seklya I. , Ogiuchi T. , Yagishita K. , Yamamoto H. , Shinomiya K. 
Published: February 2011

Muneta T, Sekiya I, Ogiuchi T, Yagishita K, Yamamoto H, Shinomiya K. Objective factors affecting overall subjective evaluation of recovery after anterior cruciate ligament reconstruction.The goal of this prospective study was to determine how objective measurements affect the overall subjective evaluation of recovery after anterior cruciate ligament (ACL) reconstruction and to evaluate the effects of graft material, residual instability and sporting activity on patient satisfaction. Ninety‐seven patients with unilateral ACL injuries whose ACL was reconstructed using either a multi‐strand semitendinosus (ST) graft or a central‐third bone‐patellar tendon‐bone (BTB) graft were followed for an average of 30 months. An “overall subjective recovery score” was derived from the patients' evaluation of function of the operated knee as a percentage of the unoperated knee. The mean overall subjective recovery score at follow‐up was 80% (range, 20% to 100%). This study strongly suggested that integrity of the knee extension mechanism, that is, good recovery of knee extension strength with achievement of full extension and no problems in the patellofemoral joint, is the most important factor in patient satisfaction after ACL reconstruction.
Effects of physical exercise on bone mass, balance skill and aerobic capacity in women and men with low bone mineral density, after one year of training ‐ a prospective study
Authors: Kronhed A. C. Grahn , Möller M. 
Published: February 2011

Grahn Kronhed AC, Möller M. Effects of physical exercise on bone mass, balance skill and aerobic capacity in women and men with low bone mineral density, after one year of training ‐ a prospective study.Vadstena is a small community in the county of östergötland, Sweden, where a project began in 1989 to prevent osteoporosis and to lower the expected incidence of osteoporotic fractures. Persons aged 40–70 years who had a low bone mineral density (BMD) value at screening of the distal radius by single‐photon absorptiometry (SPA) were invited to participate in a training study during one year. The definition of low BMD was a densitometry value below −1 SD (standard deviation) from a sex‐ and age‐specific reference value (z‐score). Fifteeen persons wanted to exercise in a group and 15 persons wanted to become a control group. All participants answered a questionnaire about lifestyle, occupation, diseases, medication and heredity. Clinical tests were made regarding mobility of the joints and muscles, balance and physical fitness. BMD for the hip and the lumbar spine were assessed by dual‐energy X‐ray absorptiometry (DXA) before and after the investigation period. The training programme was carried out for 60 min twice a week during one year and had the intention to improve bone mass, muscle strength and flexibility, balance skill and aerobic capacity. After the training period there was a significant increase in BMD at the greater trochanter (P<0.01), in balance skill (standing on one leg with closed eyes and “ski step“‐test) (P<0.05) and in oxygen uptake capacity (P<0.05) in the exercise group. In the control group, there was a significant increase in BMD at the lumbar spine (P<0.05). However, these results should be judged with caution because several participants were over the age of 60, and at that age degenerative changes in the lumbar spine may increase to a greater or lesser extent. Regular weight‐bearing exercises during one year seem to influence BMD at the greater trochanter in a training group comprising both women and men. However, our study was small in number and further training studies are needed to assess the effect of weight‐bearing training on bone mass in different sex‐ and age‐specific groups.
Prediction of physical fitness and physical activity level in adulthood by physical performance and physical activity in adolescence ‐ An 18‐year follow‐up study
Authors: Barnekow‐Bergkvist M. , Hedberg G. , Janlert U. , Jansson E. 
Published: February 2011

Barnekow‐Bergkvist M, Hedberg G, Janlert U, Jansson E. Prediction of physical fitness and physical activity level in adulthood by physical performance and physical activity in adolescence ‐ An 18‐year follow‐up study.The aim of the study was to investigate relationships between physical fitness and self‐reported physical activity in adulthood and to what extent the level of physical fitness and leisure‐time physical activity in adulthood can be explained by anthropometric measures, physical performance, physical activity, attitudes to sports activities and socio‐demographic characteristics at the age of 16. A group of 157 men and 121 women was tested at the ages of 16 and 34 by means of questionnaires and fitness tests. Physically active men and women had higher estimated VO2 max and performed better in curl ups and bench press than those who were inactive. Performance in physical tests, height, weight and physical activity at the age of 16 contributed best to explain adult physical performance and physical activity. The magnitude of explanation varied between 10% (9‐min run test) and 56% (bench press test); it was in general lower in the men than in the women. The various fitness tests and physical activity were explained by different predictors and the predictors also differed between men and women. The findings about attitudes to sports and socio‐demographic factors at a young age that influence adult physical activity habits and fitness are very complex and further research is required to identify specific inactivity risks.
Update on cosmeceuticals
Authors: Kerscher Martina , Buntrock Heike 
Published: February 2011

SummaryAs youth and perception of beauty are considered to be of great importance, an increasing number of new cosmeceuticals have been developed in recent years. This article will briefly present the problems of distinguishing cosmetics, cosmeceuticals or drugs and describe important new developments in raw materials, carrier systems and ingredients from the dermatological point of view. Especially active ingredients against skin‐aging, here in particular antioxidants and cell regulators, are reviewed. Important parameters for the quality of cosmetics and cosmeceuticals are evidence‐based in‐vivo and in‐vitro efficacy as well as scientifically proven wanted and unwanted effects.
Biofilms of Listeria monocytogenes Produced at 12 ° C either in Pure Culture or in Co‐Culture with Pseudomonas aeruginosa Showed Reduced Susceptibility to Sanitizers
Authors: Lourenço António , Machado Henrique , Brito Luisa 
Published: February 2011

Abstract:  The biofilm‐forming ability of 21 Listeria monocytogenes isolates, previously pulsotyped and corresponding to 16 strains, from different origins was evaluated using the Calgary Biofilm Device®, at 37 °C. Biofilms of 4 selected strains were also produced either on pure cultures or on co‐cultures with Pseudomonas aeruginosa (PAO1), at 12 °C and at 37 °C. For these biofilms, the minimum biofilm eradication concentrations (MBECs) of 4 commercial dairy sanitizers (1 alkyl amine acetate based—T99, 2 chlorine based—T66 and DD, and 1 phosphoric acid based—BP) were determined. Listeria monocytogenes biofilms grown, either at 37 °C or 12 °C, were able to achieve similar cell densities by using different incubation periods (24 h and 7 d, respectively). In co‐culture biofilms, P. aeruginosa was the dominant species, either at 37 °C or at 12 °C, representing 99% of a total biofilm population of 6 to 7 log CFU/peg. Co‐culture biofilms were generally less susceptible than L. monocytogenes pure cultures. More interestingly, the biofilms produced at 12 °C were usually less susceptible to the sanitizers than when produced at 37 °C. Single or co‐culture biofilms of L. monocytogenes and PAO1, particularly produced at 12 °C, retrieved MBEC values for agents T99 and BP that were, at times, above the maximum in‐use recommended concentrations for these agents. The results presented here reinforce the importance of the temperature used for biofilm formation, when susceptibility to sanitizers is being assessed.Practical Application:  Since most food plants have cold wet growth niches in production and storage areas, susceptibility testing should be performed on biofilms produced at refrigeration temperatures. Moreover, the efficiency of the sanitizers used in food industries should be performed on mixed culture biofilms, since in field conditions these will predominate. The results presented here highlight the importance of the temperature used for biofilm formation, when susceptibility to disinfectants is being assessed, as biofilms produced at lower temperature were less susceptible to sanitizers.
Highly Stable, Edible Cellulose Films Incorporating Chitosan Nanoparticles
Authors: de Moura Márcia R. , Lorevice Marcos V. , Mattoso Luiz H.C. , Zucolotto Valtencir 
Published: February 2011

Abstract:  The need for biodegradable polymers for packaging has fostered the development of novel, biodegradable polymeric materials from natural sources, as an alternative to reduce amount of waste and environmental impacts. The present investigation involves the synthesis of chitosan nanoparticles–carboxymethylcellulose films, in view of their increasing areas of application in packaging industry. The entire process consists of 2‐steps including chitosan nanoparticles preparation and their incorporation in carboxymethylcellulose films. Uniform and stable particles were obtained with 3 different chitosan concentrations. The morphology of chitosan nanoparticles was tested by transmission electron microscopy, revealing the nanoparticles size in the range of 80 to 110 nm. The developed film chitosan nanoparticles–carboxymethylcellulose films were characterized by Fourier transform infrared spectroscopy (FT‐IR), thermogravimetric analysis, solubility tests, and mechanical analysis. Improvement of thermal and mechanical properties were observed in films containing nanoparticles, with the best results occurring upon addition of nanoparticles with 110 nm size in carboxymethylcellulose films.Practical Application:  Carboxymethylcellulose films containing chitosan nanoparticles synthesized and characterized in this article could be a potential material for food and beverage packaging applications products due to the increase mechanical properties and high stability. The potential application of the nanocomposites prepared would be in packaging industry to extend the shelf life of products.
Parental acceptance of restraint methods used for children with intellectual disabilities during dental care
Authors: Oliveira Ana Cristina Borges , Paiva Saul Martins , Pordeus Isabela Almeida 
Published: February 2011

ABSTRACTThis study evaluated 209 Brazilian parents' acceptance of the use of restraint during dental care for their children with intellectual disabilities. Participants were interviewed end they also watched a video on physical restraint techniques, sedation, and general anesthesia. There was a statistically significant relationship for 22.9% of the parents. The odds ratio revealed that participants were more likely to accept physical restraints for their child when parents were over the age of 35 and from an underprivileged economic class and when the children had previously experienced physical restraints. Dental healthcare professionals should consider the individual needs of each patient and consult with the child's family if there is a need to use restraints.
LACTIC ACIDOSIS AFTER CONCOMITANT TREATMENT WITH METFORMIN AND TENOFOVIR IN A PATIENT WITH HIV INFECTION
Authors: Aperis Georgios , Paliouras Christos , Zervos Angelos , Arvanitis Antonios , Alivanis Polichronis 
Published: February 2011

SUMMARYWe present an uncommon case of lactic acidosis after concomitant administration of Metformin and Tenofovir. This is a 74‐year‐old man with a history of diabetes mellitus receiving treatment with metformin. He had coronary artery disease and HIV infection treated with emtricitabine, tenofovir and recently started on efavirenz. He presented with zoster‐like abdominal pain, tachypnoea, nausea and vomiting. On clinical examination, the patient was afebrile, hypotensive and tachycardic, he was markedly dehydrated and oliguric. The abdomen was soft, tender on palpation, not distended without rebound tenderness. The arterial blood gases revealed marked lactic acidosis and the laboratory tests on admission showed acute renal failure. The patient received nine treatments of slow continuous veno‐venous hemofiltration (CVVHF). Despite the prolonged period of anuria, urine output progressively improved after 25 days and serum biochemical parameters of renal function returned to normal within 40 days. Health professionals must be aware of this uncommon effect in patients on antiretroviral treatment. Prompt initiation of CVVHF resulted in resolution of both lactic acidosis and renal failure.
TOTAL DOSE INFUSION OF INTRAVENOUS IRON IN PATIENTS WITH CHRONIC KIDNEY DISEASE RECEIVING HAEMODIALYSIS
Authors: Fenwick Sean , Peebles George 
Published: February 2011

SUMMARYA regimen of a single high dose iron administration was initially adopted for patients commencing haemodialysis (HD) treatment. Iron stores are established and iron metabolism and erythropoiesis stabilise allowing haematinic parameters to be more confidently assessed for use in anaemia management decisions. High doses of IV iron delay the need for subsequent iron supplementation. A high‐dose, low‐frequency iron infusion regimen for all HD patients was adopted. The outcomes of administering this dosage regimen are reported as observational retrospective analysis using patient record data in 2009.Patients received three [median; semi‐interquartile range (SIQR) 0.5] high‐dose iron infusions during the year. The median infusion dose was 1100 mg iron (SIQR 0.0) and the median amount of iron received during the year by each patient was 3200 mg (SIQR 750). The median haemoglobin (Hb) level prior to infusion was 108 g/l and post infusion 114 g/l; ZHb = 2.656, p = 0.008). Ferritin levels increased from a median of 376 μg/l preinfusion to 690 μg/l postinfusion; Zferritin =–4.796, p < 0.001.The median time between infusions was 125 days (approximately four months). The 51 patients (76%) who received three or less infusions within the study period received 2537 mg (mean) of iron. These findings indicate that both Hb and ferritin levels can be adequately managed using a high‐dose, low‐frequency regimen of IV iron in patients undergoing HD.
PREVENTION OF INFECTION IN PATIENTS WITH CHRONIC KIDNEY DISEASE PART II: HEALTHCARE‐ASSOCIATED INFECTIONS
Authors: Redmond Avril , Donlon Sheila , Boyle Gerard , McCann Margaret , Einarsdottir Hildur 
Published: February 2011

SUMMARYThis second article, in a three‐part CE series on the preventions of infection in patients with chronic kidney disease, focuses on healthcare‐associated infections and blood borne viruses that are prevalent within the haemodialysis environment. It also informs the reader of the relevant infection and prevention precaution guidelines and their application within a haemodialysis setting.
Cytologic patterns of lymphadenopathy in canine monocytic ehrlichiosis
Authors: Mylonakis Mathios E. , Borjesson Dori L. , Leontides Leonidas , Siarkou Victoria I. , Theodorou Konstantina , Koutinas Alexander F. 
Published: February 2011

Background: Recognition of different cytologic patterns in lymph nodes (LNs) from dogs with canine monocytic ehrlichiosis (CME) and noninfectious causes of lymphoid reactivity may have diagnostic utility.Objectives: The aims of the present study were to compare cytologic patterns in LNs of dogs with different phases of CME, to investigate the association of cytologic pattern and presence of Ehrlichia spp. morulae, and to compare patterns of lymphoid reactivity between dogs with CME and those with noninfectious causes of lymphoid hyperplasia.Methods: Cytologic preparations of LNs from 35 dogs with nonmyelosuppressive CME (group A), 16 dogs with myelosuppressive CME (group B), 26 dogs with noninfectious diseases (group C), and 15 healthy dogs (group D) were evaluated. Percentages of lymphocyte types, plasma cells, macrophages, neutrophils, and eosinophils were determined. Samples from dogs in groups A and B were evaluated for the presence of morulae.Results: Cytologic abnormalities in LNs were recorded in 54% of dogs in group A, 88% in group B, 39% in group C, and 0% in group D and were more frequent (P=.02) in dogs with myelosuppressive CME than those with nonmyelosuppressive CME. Plasma cell hyperplasia was more frequent in CME than in noninfectious diseases (P=.03). An association between the presence of cytologic abnormalities and morulae in group A dogs was not found.Conclusions: Dogs with myelosuppressive CME have more lymphoid cytologic abnormalities than dogs with nonmyelosuppressive CME. LN plasmacytosis is the major pattern of lymphadenopathy in dogs with CME and is found more frequently in dogs with CME than in dogs with noninfectious causes of lymphadenopathy.
Serum α‐1‐acid glycoprotein concentrations in 26 dogs with pyometra
Authors: Hagman Ragnvi 
Published: February 2011

Background:The acute phase protein, α‐1‐acid glycoprotein (AGP), has been proposed to have a role in immunomodulation and to be a nonspecific antimicrobial agent. We suggest that AGP may be increased in dogs with pyometra and possibly to a greater extent in dogs also manifesting signs of systemic inflammatory response syndrome (SIRS).Objectives:Our objectives were to evaluate serum AGP concentrations in dogs diagnosed with pyometra compared with clinically healthy female dogs and to determine if AGP concentrations were correlated with severity of disease.Methods:Twenty‐six dogs with pyometra and 18 clinically healthy intact female dogs were included in this prospective study. A diagnosis of pyometra was verified by histopathologic examination after ovariohysterectomy in the pyometra group. A commercially available single radial immunodiffusion test was used for AGP analysis. Clinical findings, laboratory variables, and hospitalization times were compared.Results:Mean AGP concentration in dogs with pyometra (1943 ± 913 mg/L, mean ± SD), was significantly higher (P<.001) than in healthy dogs (495 ± 204 mg/L). Mean AGP concentration in dogs in the pyometra group with (n=18) or without (n=8) SIRS did not differ. Animals with a prolonged hospital stay had higher AGP concentrations.Conclusions:Pyometra was associated with increased serum concentrations of the acute phase protein AGP. AGP concentrations were associated with severity of disease as measured by duration of hospitalization. As AGP binds basic drugs, further studies of its pharmacokinetic and pharmacodynamic propreties in cases of pyometra may be of clinical interest.
Discovery and Phylogenetic Analysis of Novel Members of Class b Enterotoxigenic Escherichia coli Adhesive Fimbriae
Authors: Nada Rania A. , Shaheen Hind I. , Khalil Sami B. , Mansour Adel , El-Sayed Nasr , Touni Iman , Weiner Matthew , Armstrong Adam W. , Klena John D. 
Published: February 2011

ABSTRACT

Enterotoxigenic
Escherichia coli
(ETEC) is recognized to be a common cause of acute watery diarrhea in children from developing countries. Colonization factors (CFAs) have been identified predominantly in ETEC isolates secreting heat-stable enterotoxin (ST) or cosecreting ST with a heat-labile toxin (LT). We hypothesized that LT-only-secreting ETEC produces unique colonization factors not previously described in ST and LTST-secreting ETEC. A set of degenerate primers based on nucleotide sequence similarities between the major structural genes of CS20 (
csnA
), CS18 (
fotA
), CS12 (
cswA
), and porcine antigen 987 (
fasA
) was developed and used to screen a collection of 266 LT-secreting ETEC isolates in which no known CFA was detected. PCR-amplified products of different molecular masses were obtained from 49 (18.4%) isolates. Nucleotide sequence analysis of the PCR amplicons followed by GenBank nucleotide BLASTn analysis revealed five novel DNA sequences; translated amino acid BLASTx analysis confirmed sequence similarity to class 1b major structural proteins encoded by
csnA
,
fotA
, and
fasA
. Strains expressing the novel CFAs were phylotyped and analyzed using multilocus sequence typing (MLST; Achtman scheme), and the types detected were compared to those of a collection of archived global
E. coli
strains. In conclusion, application of the degenerate primer sets to ETEC isolates from surveillance studies increased the total number of ETEC isolates with detectable CFAs by almost 20%. Additionally, MLST analysis suggests that for many CFAs, there may be a requirement for certain genetic backgrounds to acquire and maintain plasmids carrying genes encoding CFAs.
Evaluation of Four Commercial Rapid Immunochromatographic Assays for Detection of Cryptosporidium Antigens in Stool Samples: a Blind Multicenter Trial
Authors: Agnamey Patrice , Sarfati Claudine , Pinel Claudine , Rabodoniriina Meja , Kapel Nathalie , Dutoit Emmanuel , Garnaud Cécile , Diouf Momar , Garin Jean-François , Totet Anne , Derouin F. ,   for the ANOFEL Cryptosporidium National Network
Published: February 2011

ABSTRACT

In a multicenter study, potassium dichromate-preserved stools from patients infected with
Cryptosporidium parvum
(
n
= 20),
C. hominis
(
n
= 20), and other
Cryptosporidium
species (
n
= 10) and 60 controls were examined using four immunochromatographic assays. Assay sensitivity ranged between 50.1% and 86.7% for
C. parvum
and C.
hominis
but was <35% for other species.
Imipenem Disc for Detection of KPC Carbapenemase-Producing Enterobacteriaceae in Clinical Practice
Authors: Benenson Shmuel , Temper Violeta , Cohen Matan J. , Schwartz Carmela , Hidalgo-Grass Carlos , Block Colin 
Published: February 2011

ABSTRACT

The global spread of class A-carbapenemase-producing
Enterobacteriaceae
has made the development of a simple test a desirable goal. A disc diffusion test using imipenem was 100% sensitive and 96% specific in identifying carbapenemase-producing organisms, potentially reducing or eliminating the need for the relatively labor-intensive modified Hodge test.
Performance of the Abbott RealTime HIV-1 Viral Load Assay Is Not Impacted by Integrase Inhibitor Resistance-Associated Mutations
Authors: Young Thomas P. , Cloherty Gavin , Fransen Signe , Napolitano Laura , Swanson Priscilla , Herman Christine , Parkin Neil T. , Hackett John 
Published: February 2011

ABSTRACTThe Abbott RealTime HIV-1 viral load assay uses primers and probes targeted to integrase, which is also the target of integrase inhibitors such as raltegravir. Viral loads of 42 raltegravir-susceptible and 40 raltegravir-resistant specimens were determined using RealTime HIV-1 and Roche Monitor (v1.5). The differences in viral load measurements between assays were comparable in the two groups, demonstrating that the RealTime HIV-1 assay can tolerate raltegravir-selected mutations.