bluuebunny/crossref_metadata_2025_split huggingface dataset:
Human immunodeficiency virus protease inhibitors reduce the growth of human tumors via a proteasome‐independent block of angiogenesis and matrix metalloproteinases
Authors: Toschi Elena , Sgadari Cecilia , Malavasi Laura , Bacigalupo Ilaria , Chiozzini Chiara , Carlei Davide , Compagnoni Daniela , Bellino Stefania , Bugarini Roberto , Falchi Mario , Palladino Clelia , Leone Patrizia , Barillari Giovanni , Monini Paolo , Ensoli Barbara 
Published: July 2010

AbstractHuman immunodeficiency virus protease inhibitors (HIV‐PIs), such as indinavir and saquinavir, have been shown to block angiogenesis and tumor cell invasion and to induce tumor cell apoptosis and growth arrest, respectively, both in vitro and in vivo. These findings have suggested that HIV‐PIs or their analogues can be used as antitumor drugs. To this regard, indinavir and saquinavir were assessed for their ability to inhibit in vivo the growth of highly prevalent human tumors, such as lung, breast, colon and hepatic adenocarcinomas. We show here that both HIV‐PIs significantly inhibited the growth of all adenocarcinomas tested in the mice model. This was not mediated by effects on proteasome‐dependent cell growth arrest or on apoptosis but by the block of angiogenesis and matrix metalloproteinase activity. Accordingly, therapeutic steadystate concentrations of indinavir or saquinavir were highly effective in inhibiting invasion of tumor cells in vitro. In contrast, growth arrest was induced only by high concentrations of saquinavir that are not reached or are only transiently present in plasma of treated patients, likely through a proteasome‐mediated mechanism. These data suggest that HIV‐PIs or their analogues, characterized by a better biodistribution and lower toxicity, may represent a new class of antitumor drugs capable of targeting both matrix metalloproteinases and the proteasome for a most effective antitumor therapy.
Collagen/heparin coating on titanium surface improves the biocompatibility of titanium applied as a blood‐contacting biomaterial
Authors: Chen Jialong , Chen Cheng , Chen Zhuoyue , Chen Junying , Li Quanli , Huang Nan 
Published: July 2010

AbstractThrombosis and restenosis are the main causes leading to failure of cardiovascular and other blood‐contacting biomedical devices. It is recognized that rapid re‐endothelialization is a promising method for preventing these complications. This article deals with improving the endothelial progenitor cell (EPC) compatibility and hemocompatibility of titanium by coating an extracellular matrix‐like film with heparin(hep) and collagen(col) by a layer‐by‐layer (LBL) self‐assembly technique. In the work described here, LBL‐produced col/hep coating growth is initialized by deposition of a layer of poly‐L‐lysine on a titanium surface, which is negatively charged after treatment with NaOH, followed by formation of a multilayer film formed by alternating deposition of negatively charged heparin and positively charged collagen using electrostatic interaction. The X‐ray photoelectron spectroscopy results and fluorescence staining of collagen show that collagen is predominant on the surface and that collagen interpenetrates the heparin layer.In vitroEPC attachment and proliferation increase greatly on the col/hep coating. Immunofluorescent staining of cytoskeleton actin reveals that cells on the col/hep coating form a compact confluent cell layer after culture for 3 days. After culture for 5 days, cell viability on the col/hep increases persistently and on titanium the cell viability begins to decrease, showing that the coating possesses the ability to maintain cell viability. Platelet adhesion under dynamic conditionsin vitroimplies that the hemocompatibility of the col/hep coating is superior to that of titanium. The col/hep coating improves the biocompatibility of titanium and has good potential for application in blood‐contacting biomaterials. © 2010 Wiley Periodicals, Inc. J Biomed Mater Res Part A, 2010.
Rinseback during red blood cell exchange with COBE Spectra does not affect fraction of cells remaining or post‐exchange hematocrit
Authors: Bhagat Ramesh , Matevosyan Karén , Jones Rebecca , Vetus Maria L. , Burner James , Sarode Ravi 
Published: July 2010

AbstractCaridianBCT currently does not recommend rinseback with its COBE Spectra cell separator during red blood cell (RBC) exchange procedure, as the machine's software does not take into account the “rinseback” when calculating the fraction of cells remaining (FCR, and therefore target hemoglobin S (HbS) value) and postexchange hematocrit (Hct). To our knowledge, no study has investigated the effect of rinseback on these laboratory values. Therefore, we performed pre‐ and postrinseback evaluations of FCR and Hct in 22 consecutive combined Isovolemic Hemodilution/Red blood cell (IHD‐RBCx) exchange procedures in sickle cell anemia patients with stroke currently enrolled in our institution's chronic RBC exchange program. The pre‐ and‐post rinseback values for HbS were 9.9 ± 4.66 and 10.7 ± 4.83 (P = 0.56) with corresponding FCRs of 22.6 ± 8.57 and 24.7 ± 8.75 (P = 0.44), and for Hct were 32.4 ± 2.93% and 32.2 ± 3.19% (P = 0.79), respectively. Since there was no significant difference in the “pre” and “post” values, we conclude that rinseback can be used during RBC exchange without any concern for significantly affecting Post Exchange HbS and Hct and possibly not waste 53 mL of precious red cell mass in the rinseback. J. Clin. Apheresis, 2010. © 2010 Wiley‐Liss, Inc.
Ion Exchange Properties of Pyridinium Molybdoarsenate
Authors: Jain Ajay K. , Srivastava Suresh K. , Singh Raj P. , Agrawal Sushma 
Published: July 2010

AbstractThe ion exchange behaviour of pyridinium molybdoarsenate has been investigated with some uni‐ and bi‐valent cations. The slopes of the isotherms are widely different for various cations suggesting that separation of these ions is feasible. Barrer's equation has been applied to the exchange reaction and various thermodynamic parameters, viz. interaction energy between the ions on surface, thermodynamic equilibrium constant and free energy change for the exchange process, have been evaluated. This exchanger is found to be highly specific for Tl+ ions and can be used for its removal from mixtures of various uni‐ and bi‐valent cations.
Pore Structure of Silica Gel
Authors: Saran Tripurari , Paul Indu B. , Chatterjee Deb S. , Ramachandran Lakshminarayanapuram V. , Mukherjee Phanindra N. 
Published: July 2010

AbstractThe effect of washing on the texture of silica gel has been investigated in terms of parameters such as porosity, pore size distribution, surface area and absorption of moisture. It was observed that if silica gel (before activation) is washed with water containing dissolved ions such as Ca and Mg wider pores are formed at the expense of smaller ones. This phenomenon has been explained in terms of change in the size distribution of gel particles which is brought about by solution of very fine particles followed by growth, through condensation, of larger particles. The experimental observations have been interpreted to suggest guidelines to control the texture of gels by washing with solutions comaining different cations.
Kinetics of the hydrolysis of ethyl acetate catalysed by cation‐exchange resin
Authors: Rajamani Kuppuswami , Shenoy Subhash C. , Rao Musti S. , Rao Manthripragada G. 
Published: July 2010

AbstractThe mechanism of the hydrolysis of ethyl acetate, catalysed by Dowex 50 W resins, was studied using a batch reactor. The effects of resin cross‐linkage and initial reactant ratio on the conversion were investigated. At the high stirring speed used, the film diffusional resistance was found to be insignificant. The results were analysed using the Langmuir‐Hinshelwood models. It was found that the irreversible surface reaction between ethyl acetate and water in the adsorbed state (dual site mechanism) was the most plausible rate‐controlling step. The rate data were best denoted by the model:

where a1 denotes the activity of the species i.
Synthesis of molybdenum(IV) sulphide: I. Reaction of hydrogen sulphide with molybdenum(vi) oxide in the presence of ammonium chloride
Authors: Bhuiyan Nurul Haque 
Published: July 2010

AbstractMolybdenum(VI) oxide reacted with hydrogen sulphide to give, either a mixture of molybdenum(IV) sulphide and molybdenum(IV) oxide, which is very difficult to separate, or, at higher temperatures molybdenum(IV) oxide only. In the presence of ammonium chloride, the reaction gave pure lubricant grade molybdenum(IV) sulphide. The reaction was studied with different process variables. Under optimum can be conditions 81.5% pure MoS2 was obtained at 700°C. The overall reaction represented as:

The densities of the products were measured. X‐ray diffraction patterns of pure samples were taken.
Virtual electron microscopy in cell biology
Authors: Mione Sylvia , Bacher Klaus , Thierens Hubert , Cornelissen Maria 
Published: July 2010

AbstractVirtual microscopy of histological glass slides can emulate conventional light microscopy. Up till now, such a digital simulation does not exist for ultrathin electron microscopic slides. Because of the relative inaccessibility of electron microscopy, evaluation of subcellular structures by (bio)medical students is performed with the aid of photographic prints. In this article, the generation and evaluation of virtual electron microscopic slides is discussed. A T‐lymphoblastic cell was used as an example. Electron microscopic pictures were taken at two magnifications (25,000 and 50,000), processed in an analogue or digital way and stitched to reconstruct the image of the total cell. This image is viewed with a webviewer equipped with pan and zoom functions. The possibility of distinguishing the trilaminar structure of cellular membranes was the requisite. Virtual images obtained at an original magnification of 25,000, scanned at a resolution of 800 ppi could compete with pictures developed directly from negatives obtained by electron microscopy. It is possible to navigate and zoom into details in a way emulating electron microscopy. Virtual electron microscopy is innovative and offers new perspectives to interpret cytological pictures and to teach cell biology in an interactive and unique way. Microsc. Res. Tech., 2010. © 2010 Wiley‐Liss, Inc.
Acetic acid treatment for wrinkle‐free oral mucosal epithelia in paraffin section preparation
Authors: Ahsan MD. Shahidul , Maruyama Satoshi , Cheng Jun , Al‐Eryani Kamal , Yamazaki Manabu , Hasegawa Mayumi , Tsuneki Masayuki , Saku Takashi 
Published: July 2010

AbstractFor histopathological assessment of oral borderline malignancies, it is important to carefully detect subtle epithelial changes on fully stretched tissue sections. However, it is not generally easy to obtain wrinkle‐free sections when using formalin‐fixed paraffin‐embedded oral mucosal samples. Since acetic acid treatment is already utilized for large brain tissue sections, we examined whether that treatment was also effective for oral mucosal tissues containing normal to malignant epithelial lesions. Paraffin sections were floated in various concentrations of acetic acid for 10 min after stretching in water for 1 min, then wrinkle formations were examined using hematoxylin and eosin staining, as well as for staining intensity with keratin immunohistochemistry. Wrinkles were formed in both epithelial and connective tissue zones of sections treated with less than a 40‐mM (0.25%) concentration of acetic acid. In contrast, treatments with concentrations at 80 mM (0.5%) and higher resulted in cracking between the epithelial layer and lamina propria, as well as poor immunohistochemical results for keratins 13 and 17, even though the wrinkles completely disappeared. These results indicate that 40 mM is the optimal concentration of acetic acid solution to prevent wrinkles in the epithelial layer while maintaining the immunohistochemical qualities of oral mucosa tissue sections, especially those containing borderline malignant epithelial lesions. Microsc. Res. Tech., 2010. © 2010 Wiley‐Liss, Inc.
Technique for visual demonstration of germinating arbuscular mycorrhizal spores and their multiplication in pots
Authors: Panwar Jitendra , Tarafdar Jagadish C. , Yadav Ranjeet S. , Saini Vinod K. , Aseri Gajendra K. , Vyas Anil 
Published: July 2010

AbstractWe describe a simple technique for the germination of arbuscular mycorrhizal (AM)–fungal spores and their multiplication in pots. Glomus fasciculatum, G. mosseae, and Gigaspora margarita were used. A single wheat seedling was tied to a glass slide, previously covered with filter paper with the help of thread. One single surface‐sterilized AM‐fungal spore was placed on the middle portion of the root of the wheat seedling using a sterilized syringe. The slide was placed vertically in a 100 mL glass beaker filled with 25 mL of root exudates–water (1:4, v/v) solution, which was collected by growing twenty wheat seedlings in a 150 mL beaker filled with 100 mL sterilized distilled water for 7 d. The slide was observed daily using a compound microscope to follow the time course of germination. In this technique, the spore is directly in contact with the host root, and a visualization of spore germination, hyphal development, and appressorium formation is possible without disrupting fungal growth or the establishment of the symbiosis. The method allows to document the germination events and to assess hyphal‐elongation rates by photographing the same spore on consecutive days. The inoculated seedling was used to initiate single‐spore multiplication in a sterilized (autoclave on 3 alternate days at 120°C for 120 min at 1.05 kg cm–2 pressure) potted sandy soil (150 mL volume) into which the slide with the inoculated seedling was inserted carefully through a previously made slit. The wheat seedlings in all pots (4 treatments and 15 replications) became colonized by mycorrhiza, confirming that the establishment of the AM‐fungal symbiosis is highly reproducible. Our technique permits the relatively undisturbed growth of the symbiotic partners, the visualization of germinating AM‐fungal spores, and their multiplication in pots. This simple and low‐cost method facilitates the production of pure lines of AM fungi from single spores, allowing for the study of intraspecific variation and potentiality for cytological, biochemical, physiological, and taxonomical studies.
Podzol: Soil of the Year 2007. A review on its genesis, occurrence, and functions
Authors: Sauer Daniela , Sponagel Herbert , Sommer Michael , Giani Luise , Jahn Reinhold , Stahr Karl 
Published: July 2010

AbstractThe Podzol has been elected “Soil of the year 2007” in Germany. This article reviews the present knowledge on the development, functions, and threats of Podzols. The main theories on mobilization and transport of organic matter, Fe, Al, and Si are (1) metal‐organic migration, (2) metal reduction, and (3) inorganic sol migration. Immobilization theories include precipitation or polymerization due to increasing pH/abundance of base cations with depth, mechanical filtering in soil pores, oxidation of metal‐organic complexes, biodegradation of the organic part, decreasing C‐to‐metal ratios during translocation, adsorption to soil particles, and flocculation at the point of zero charge. Podzolization is discussed also on the catena scale, where vertical and lateral translocation processes (across pedon boundaries) need to be considered to understand Podzol patterns in landscapes. Chronosequence studies show that incipient podzolization usually becomes visible between 100 and 500 y and mature Podzols develop in 1,000–6,000 y. The occurrence of Podzols worldwide is concentrated mainly on the boreal zone and mountain regions within the humid temperate zone. Smaller Podzol areas are found in some perhumid tropical and subtropical regions. In Germany, Podzols occur in the Alps, in the glaciofluvial valleys and heathlands of N Germany, and in the mountain ranges. They fulfil several ecological functions, especially for groundwater recharge. Main threats for these mostly sandy soils are wind erosion and surface mining of sand. Two pedons which were chosen to represent the “Soil of the year 2007” are presented. Finally, some conclusions about podzolization processes are drawn, which may explain the diverse observations reported in the literature.
Type, Cotype Constants and Clarkson's Inequalities for Banach Spaces
Authors: Kato Mikio , Takahashi Yasuji 
Published: July 2010

AbstractIt is shown that a Banach space satisfies Clarkson's inequalities if and only if its “type or cotype constant” is 1, which implies in particular that the notions of Go ‐ and Gn ‐ Fourier type by Milman [16] are equivalent. A sequence of related results is also given.
A case–control study of multiple system atrophy in Korean patients
Authors: Seo Joo‐Hyun , Yong Seok Woo , Song Sook K. , Lee Ji E. , Sohn Young H. , Lee Phil Hyu 
Published: July 2010

AbstractA few case–control studies of multiple system atrophy (MSA) have been reported in Western populations. In this study, we included various epidemiological factors to evaluate whether the risk factors for MSA differed in Korean and Western populations. A total of 100 consecutive MSA patients and 104 controls at two referral hospitals participated. Information was obtained through face‐to‐face interviews using a structured questionnaire: history of living area, occupational history, food habits, alcohol and tobacco consumption, and use of drugs. Odds ratios and 95% confident intervals (OR [95% CI]) were computed using logistic regression. The multivariate logistic regression analysis revealed that use of antihypertensive medication (OR = 0.30 [0.12–0.78]) and vitamins (OR = 0.30 [0.14–0.64]) and consumption of meat and poultry (OR = 0.27 [0.13–0.56]) were associated with decreasing risk for MSA, whereas use of herbal medications (OR = 3.17 [1.28–7.84]) was associated with increasing risk for MSA. In univariate analysis adjusted for age, sex, education level, and recruitment center, use of aspirin (OR = 0.21 [0.07–0.61]) and coffee consumption (OR = 0.44 [0.23–0.84]) were significantly less frequent in MSA patients than in controls, whereas heavy smoking (≥40 pack‐years) was significantly more prevalent in MSA patients than in controls (OR = 3.44 [1.05–11.23]). There was no difference in living area, participation in farming, or exposure to agrichemicals and solvents between groups. This study showed that MSA in Korea is characterized by risk factors that are both similar to and different from those affecting Western populations and that herbal medicines constitute a new MSA risk factor for the Korean population. © 2010 Movement Disorders Society
Die Mallophagengattung Trinoton
Authors: Eichler Wolfdietrich , Mitwirkung unter , Vasjukova Tamara T. 
Published: July 2010

AbstractThe available literature on Trinoton species is analyzed and reviewed. Rich material especially from Yakutia is studied. The taxonomic features of species and subspecies are compared. A new species is described, Trinoton verakopskeae spec. nov. from Baikal teal, Nettion (Sibirionetta) formosum. Some more probably new subspecies or species are discussed.
Die Untergattung cosmolaelaps berlese, 1903, der Raubmilbengattung hypoaspis canestrini, 1884 (Acarina, Parasitiformes)
Authors: Karg Wolfgang 
Published: July 2010

AbstractThe subgenus Cosmolaelaps BERLESE of Hypoaspis CANESTRINI is revised. Keys for determination of the females of 40 species are arranged. 9 new species are described and documented by figures. The subgenus is divided into 3 species‐complexes.
Die Köcherfliegenfauna der Mongolei (Insecta, Trichoptera)
Authors: Mey Wolfram , Dulmaa Ayuur 
Published: July 2010

The Caddisflies of Mongolia (Insecta, Trichoptera)The paper presents a complete list of caddisfly species that have been recorded in the Mongolian People's Republic. Distributional records, collecting sites and seasonal occurrence of each are indicated. Annotations for some species include notes on taxonomic and zoogeographic problems. At present a total of 94 species are recorded from localities in Mongolia. It is expected that this number will increase considerably in the next years.
Beiträge zur Insektenfauna der DDR: Coleoptera – Bruchidae (Chrysomeloidea). I. Zur Biologie und Verbreitung
Authors: Wendt Hella 
Published: July 2010

On the Biology and Distribution of Bruchidae (Coleoptera, Chrysomeloidea) in the GDRAbout 6000 specimens of 11 genera of Burchidae from many localities of the GDR have been studied. 14 species are thriving now in the natrual habitats whereas further species have been brought in once several times some of which became pests to legumens thus having a temporal economic significance. The family Bruchidae, three subfamilies and most of the species hitherto recorded in the GDR are characterised and their distribution is given in detail.
Bemerkungen über die Sammlung der Cyprinodontiformes (Pisces: Teleostei) des Zoologischen Museums Berlin. I. Die Gattungen Aphyosemion Myers, 1924 und Fundulosoma Ahl, 1924. Teil 1
Authors: Seegers Lothar 
Published: July 2010

Remarks on the Collection of Cyprinodontiformes (Pisces: Teleostei) of the Zoological Museum, Berlin. I. The Genera Aphyosemion Myers, 1924 and Fundulosoma Ahl, 1924. Part 1This paper is the first part of a revision of the type specimens of the Cyprinodontiformes sensu PARENTI (1981) of the ichthyological collection of the Zoological Museum Berlin including most species of the genus Aphyosemion MYERS, 1924 as we understand these species and its synonyms nowadays.
Bemerkungen über die Sammlung der Cyprinodontiformes (Pisces: Teleostei) des Zoologischen Museums Berlin. I. Die Gattungen Aphyosemion MYERS, 1924 und Fundulosoma AHL, 1924. Teil 2
Authors: Seegers Lothar 
Published: July 2010

Remarks on the Collection of Cyprinodontiformes (Pisces: Teleostei) of the Zoological Museum Berlin I. The Genera Aphyosemion MYERS, 1924 and Fundulosoma AHL, 1924. Part 2The species of the genera Aphyosemion MYERS, 1924 and Fundulosoma AHL, 1924 which are not mentioned in the first part of this revision of the type specimens of these genera stored in the collections of the Zoological Museum of Berlin are included in this second part.
Kritischer Katalog der Typen der Fischsammlung des Zoologischen Museums Berlin. Teil 2: Agnatha, Chondrichthyes
Authors: Paepke Hans‐Joachim , Schmidt Karin 
Published: July 2010

Critical Catalogue of the Types of the Fish Collection of the Zoological Museum Berlin. Part 2: Agnatha, ChondrichthyesThis paper is the second part of the catalogue of the Agnatha and fish types stored at the Zoological Museum of the Humboldt‐University of Berlin. It includes the types of the Agnatha classes Myxini and Cephalaspidomorphi with the orders Myxiniformes and Petromyzontiformes as well as the types of the Gnathostomata class Chondrichthyes with the orders Chimaeriformes, Squaliformes, Squatiniformes, Orectolobiformes, Lamniformes, Carcharhiniformes, Torpediniformes, Rajiformes and Myliobatiformes. Some remarks about the history and special problems of the research activities on this groups in the 19th century in Berlin (connected with the names of J. MÜLLER and F. G. J. HENLE as well as some others) are given in a short introduction.
Beiträge zur Insektenfauna der DDR: Coleoptera – Bruchidae (Chrysomeloidea). II. Bestimmungstabellen der heimischen Arten
Authors: Wendt Hella 
Published: July 2010

Determination Keys for the Species of Bruchidae (Coleoptera, Chrysomeloidea) in the GDRIn continuation of part I, determination keys for the species of Bruchidae hitherto recorded in the GDR are given.