bluuebunny/crossref_metadata_2025_split huggingface dataset:
Exploring the Rehabilitation Needs of Patients with Coronary Artery Diseases: An Effort to Design A Contextual Home-based Cardiac Rehabilitation through A Qualitative Enquiry
Authors: Yaqoob Adnan , Barolia Rubina , Ladak Laila , Khan Aamir Hameed , Pannu Furqan Yaqub , Hanif Asif , Sahar Wajeeha 
Published: May 2024

Abstract

Background
Cardiovascular diseases (CVDs) continue to be a major global public health concern, accounting for a considerable portion of the burden of morbidity and mortality. The CAD in Pakistan imposes a substantial economic and social burden on individuals, families, and the healthcare system. Despite advances in medical interventions and therapies, comprehensive cardiac rehabilitation programs in Pakistan remain underdeveloped and inaccessible to many patients, particularly those residing in rural or underserved areas.
Aim
This study aims to explore the needs of Pakistani patients with heart disease in helping to design contextual home-based cardiac rehabilitation.
Methods
Based on the data saturation, 20 individuals were interviewed using a qualitative descriptive exploratory approach. Semi-structured, in-depth interviews that lasted 40 to 50 minutes were used to gather the data. NVIVO software was used to conduct a thematic analysis of qualitative data.
Results
The qualitative data obtained from participants revealed five themes: Understanding heart disease, Cardiac anxiety, Challenges faced by patients, Difficulties in behavior change, and Patient readiness for home-based cardiac rehabilitation.
Conclusion
The findings uncover the importance of tailored interventions that address patients' preferences for guidance, support, and lifestyle modification.
Cerebral venous thrombosis with myelodysplastic syndrome: a rare case report
Authors: Zhang Jia , Jiang Tianfang , Chen Xu 
Published: May 2024

Abstract

Background: Cerebral venous thrombosis (CVT) is an important cause of stroke in young adults caused by complete or partial occlusion of the cerebral major venous sinuses or smaller feeding cortical veins. Myelodysplastic syndrome (MDS) represents a heterogeneous group of myeloid neoplasms that are characterized by ineffective hematopoiesis, variable cytopenias, and a risk of progression to acute myeloid leukemia. However, CVT is rarely reported in patients with MDS.
Case presentation: A 45-year-old woman with recurrent chronic headache for three months. Later, the headache symptoms gradually worsened, accompanied by disturbance of consciousness and cerebral hemorrhage. Multiple thromboses of the intracranial venous sinus were confirmed by cranial magnetic resonance venography (MRV). After treatment with heparin anticoagulation and mannitol dehydration, the symptoms gradually improved, and the hematoma was absorbed before discharge. Bone marrow biopsy revealed morbid hematopoiesis in the erythroid system and 10% of the circular iron granulocyte erythrocytes. Whole-exon detection revealed U2AF1 c.101C>T, CEBPA c.283G>A, and KMT2D c.468T>G gene mutations, which confirmed the diagnosis of MDS.
Conclusions: MDS complicated with venous sinus thrombosis is rare. A highindex of suspicion is needed for a correct diagnosis of CVT presenting with ICH or chronic headache in female patients.
TFAM downregulation contributes to cognitive dysfunction after anesthesia and surgery by activating STING-dependent endoplasmic reticulum stress and neuroinflammation
Authors: Zhu Yongliang , Fu Youli , Lian Jiahe , Liu Yinglong , Liu Yongxin , Huang Jingyao , Liu Jie , Zhang Zhihao , Zhang Zhenjiang , Zhang Rui 
Published: May 2024

Abstract

Background
Perioperative neurocognitive disorder (PND) is a common neurological complication during the perioperative period in the elderly, but no ideal prevention and treatment strategy has been found yet. cGAS-STING pathway has confirmed to play vital roles in to neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease and Huntington's disease. However, whether the cGAS–STING pathway participates in the regulatory process of neuroinflammation and apoptosis in the development of PND and the underlying mechanisms involved remain unclear.
Methods
In this study, 18-month-old C57BL/6 male mice were subjected to tibial fracture surgery with sevoflurane anesthesia to establish the PND animal model. In the interventional study, mice were treated with the cGAS inhibitor RU.521 or the combination of RU.521 and the STING agonist 2′3′-cGAMP. On the third and fourth postoperative days, novel object recognition(NOR)test and Y maze test were performed to assess the cognitive function in each group of mice. Thereafter, we determined the protein levels of TFAM, cGAS, STING, and GRP78, as well as the mRNA levels of the typical inflammatory factors IL-6, IL-1β and TNF-α in the hippocampus. In addition, we investigated the apoptosis in the hippocampus after the surgery by detecting Bax, Bcl2 apoptotic proteins, and the terminal deoxynucleotidyl transferase dUTP nick end labelling (TUNEL) staining assay.
Results
After anesthesia and surgery, the expression of TFAM in the hippocampus were down-regulation, leading to mitochondrial dysfunction, which further induced mitochondrial DNA (mtDNA) leakage into the cytoplasm. As the important source of damage-associated molecular patterns (DMAPs), the leaked mtDNA was recognized by the cytoplasmic DNA receptor cGAS, which activated the expression of downstream STING genes, causing endoplasmic reticulum stress (ERS), neuroinflammation and neuronal apoptosis in the hippocampus, and ultimately led to cognitive dysfunction in aged mice.
Conclusions
Collectively, our results revealed that TFAM downregulation contributes to cognitive dysfunction after anesthesia and surgery by activating STING-dependent ERS, neuroinflammation, and neuronal apoptosis in the hippocampus, which might serve as a promising therapeutic target for cognitive dysfunction after anesthesia and surgery.
"Pure" robot simple hysterectomy with four arms and no uterine manipulator: a retrospective, non-blind, and non-randomized, comparative study
Authors: Kawamura Shogo , Ota Kuniaki , Fujiwara Hitomi , Tasaka Keiichiro , Okamoto Hana , Morimoto Yumiko , Saito Wataru , Sugihara Sayaka , Koike Eiji , Takahashi Toshifumi , Shiota Mitsuru , Shimoya Koichiro , Ota Yoshiaki 
Published: May 2024

Abstract

Nearly 20 years have passed since the introduction of robotic surgery for total hysterectomy, and its development has accelerated. However, its advantages over laparoscopic and open surgeries remain unclear, especially since some its drawbacks include the requirement of skilled assistants and the effective use of the robotic arms. We developed a robotic hysterectomy technique (pure robotic simple hysterectomy [PRSH]). PRSH uses four robotic arms without interference and does not require a uterine manipulator, thereby minimizing the number of assistants. However, intraoperative use of a uterine manipulator may be necessary in some cases. We retrospectively compared the characteristics and surgical outcome of patients who underwent PRSH (113 patients) or PRSH with a uterine manipulator (58 patients). Patients in the PRSH group were significantly older and had significantly higher BMI than those in the PRSH with a uterine manipulator group (48.4 ± 6.3 versus 46.0 ± 5.5, P = 0.02 and 24.4 ± 4.3 versus 26.0 ± 4.6, P = 0.03, respectively). There were no statistically significant differences between the two subgroups in terms of type of benign disease. We additionally investigated the factors that necessitated the intraoperative use of a uterine manipulator using multivariate logistic analysis. We found that in complex cases, such as endometriosis with suspected Pouch of Douglas obliteration (PRSH versus PRSH with a uterine manipulator: 1.8% versus 25.9%, P < 0.0001) and cervical and broad ligament fibroids, it was difficult to continue with the uterine manipulator-free technique, requiring the intraoperative addition of a uterine manipulator. We suggest that in such cases, assistants should be prepared preoperatively to regulate uterine manipulation.
Efficacy and Safety of Immune Checkpoint Inhibitors Combined with Iodine-125 Seed Implantation in Driver-Gene-NSCLC: A Retrospective Study
Authors: Tao Xipeng , Liang Lan , Xu Junjie , Xie Lici , Wen Qing , Zhou Xiangdong , Luo Hu 
Published: May 2024

Abstract

Retrospective analysis of 95 patients with driver gene-negative NSCLC who visited First Affiliated Hospital of Army Medical University between December 2018 and December 2023. Among them, 33 cases in the observation group were treated with I125 seed implantation combined with chemotherapy and ICIs(ICIs + CT + I125), and 62 cases in the control group were treated with extracorporeal radiotherapy combined with chemotherapy and ICIs(ICIs + CT + RT). The primary observational endpoint was median progression-free survival(mPFS), while the secondary observational endpoints included the 1 and 2-year PFS rate and the incidence of adverse events. mPFS was not reached in the observation group and 11.8 months(95%CI 9.743–13.857) in the control group, a statistically significant difference(P<0.001). The restricted mean survival time (RMST) was 22.2(95% CI 18.257–26.101) and 13.8 months (95% CI 11.912–15.718) in both groups at 31.7 months, PFS was better in the observation group than in the control group. In the observation group, 2 cases(6.1%) developed grade 3 pneumothorax or hemorrhage, and in the control group, 16 cases(25.8%) developed grade 3 radiation pneumonitis, which was higher in the control group than in the observation group (P = 0.019). Compared to radiotherapy in combination with chemotherapy and immunotherapy, patients with driver gene-negative NSCLC who received I125 seed implantation had greater advantages about their longer survival and fewer adverse effects.
Length of hospital stay for liver cancer patients: risk factors and predictive model construction
Authors: Sun Bin , He Xiuying , Zhang Na 
Published: May 2024

Abstract

Purpose:
In the context of rapid rehabilitation, the length of hospital stay can serve as a reflection of the overall diagnosis and quality of nursing care provided. However, the factors influencing the duration of hospitalization in patients with primary liver cancer are currently not well understood. This research aimed to develop a predictive model for evaluating the length of hospital stay of patients.
Methods:
Admitting information of patients with liver cancer and undergoing surgical treatment were included in this study. This research analyzed 31 indicators. A binary logistic regression model was constructed with the length of hospital stay greater than the median as the dependent variable and presented in a line chart format. The performance of the line chart was tested through ROC curve, calibration plot, and decision curve analysis. Furthermore, the model underwent internal validation by utilizing the validation dataset.
Results:
This study included a total of 966 patient data. The research cohort was randomly divided into a training set and a validation set in a 7:3 ratio. Multifactor logistic regression analysis showed that factors such as Cholinesterase are predictive factors for prolonged hospital stay in patients with primary liver cancer. The nomogram model constructed using these factors demonstrated good consistency and accuracy. The AUC of the prediction model and internal validation set were .66 (95% CI .61-.70) and .56 (95% CI .49-.63) respectively. Hosmer-Lemeshow test values were p = .857 and p = .590. The calibration curve showed significant consistency between the nomogram model and actual observations. ROC and DCA indicated that the nomogram has good predictive performance.
Conclusion:
The model serves as a valuable tool for healthcare professionals to anticipate the risk factors associated with extended hospital stays in patients diagnosed with primary liver cancer.
Data-driven Design of Electrolyte Additives for High-Performance 5 V LiNi0.5Mn1.5O4 Cathodes
Authors: Liao Chen , Wang Bingning , Doan Hieu , Son Seoung-Bum , Abraham Daniel , Trask Stephen , Jansen Andrew , Xu Kang 
Published: May 2024

Abstract

LiNi0.5Mn1.5O4 (LNMO) is a high-capacity spinel-structured material with an average lithiation/de-lithiation potential at ca. 4.6–4.7 V, far exceeding the stability limits of electrolytes. An efficient way to enable LNMO in lithium-ion batteries is to reformulate an electrolyte composition that stabilizes both graphitic (Gr) anode with solid-electrolyte-interphase (SEI) and LNMO with cathode-electrolyte-interphase (CEI). In this study, we selected and tested a diverse collection of 28 single and dual additives for the LNMO||Gr system. Subsequently, we trained machine learning (ML) models using this dataset and employed these models to identify 6 optimal binary compositions out of 125, based on their predicted final area-specific-impedance, impedance-rise, and final specific-capacity. The additives generated through this ML approach demonstrated superior performance compared to those in the in the initial dataset. This finding not only underscores the efficacy of ML in identifying new materials in a highly complicated application space, but also showcases an accelerated material discovery workflow that directly integrates data-driven methods with battery testing experiments.
A Naturalistic Follow-up Study Focusing on Potential Sex Differences in Children and Adolescents with ADHD and Co-occurring Psychiatric Disorders
Authors: Uygun Sabide Duygu , Kosku Zeynep Toprak , Temeltürk Rahime Duygu , Uytun Merve Çıkılı , Yürümez Esra , Öztop Didem Behice , Babayiğit Tuğba Menteşe , Efendi Gökçe Yağmur , Kılıç Birim Günay 
Published: May 2024

Abstract

A retrospective study assessed the prevalence, timing, and distribution of psychiatric comorbidities in 322 Turkish children with ADHD (aged 6–18 years), focusing on potential sex differences. Data were collected from university-based clinical records. Assessments included periodic psychiatric examination, Wechsler Intelligence Scale for Children-Revised (WISC-R) and Conners’ Parent/Teacher Rating Scales (CP/TRS). Females with ADHD had higher psychiatric comorbidity rates compared to males (83.5% vs. 62.7%, p < .001). Intellectual disabilities and speech disorders were more prevalent in females (p < .001 and p = .028, respectively). Anxiety disorders were prevalent in both sexes. Higher rates of internalizing and externalizing disorders were observed in females. CTRS scores and indexes showed mild negative correlations with the timing of the first comorbidity other than neurodevelopmental disorders. Age and specific learning disorders (SLD) were predictors of comorbidity onset (p = .004 and p = .001, respectively). Females with ADHD need more clinical attention. ADHD severity, age, and SLD are important for the onset of comorbidities.
Application of chitosan-citric acid variant resins in the cyclic sorption-desorption of toxic ions from Zn dominant Adsorbate system
Authors: Patel Prabhat Kumar , Pandey Lalit Mohan , Uppaluri Ramagopal V.S 
Published: May 2024

Abstract

Targeted sorbents for the real-world adsorptive separation of heavy metals shall exhibit high sorption capacity, reusability, and cost-effectiveness. In this study, a novel composite sorbent has been synthesized for the concurrent mitigation of iron, lead, and zinc metal ions from synthetic wastewater systems. For this purpose, chitosan with alternate molecular weight (low, medium, and high) and with hydroxyl and amine functional groups was employed as a substrate. The successful anchoring of the organic compound citric acid was achieved with the glutaraldehyde crosslinker. The work focused on the concurrent elimination of iron, lead, and zinc ions under diverse conditions of sorbent dose (0.2 to 2 g L− 1), initial concentration (194.9-584.7 mg L− 1, 2.65–7.95 mg L− 1, and 104.8-314.4 mg L− 1 respectively for zinc, lead, and iron), and adsorbent contact duration (5 to 720 min). Accordingly, it was ascertained that other alternative ions in the adsorbate system significantly alter the sorption patterns. Following this, the desorption of metal ions was effective with simple basic and acidic eluents and for a three-cycle-based simultaneous regeneration. In summary, the findings demonstrate the promising performance of the sorbent for metal ions eradication from intricate solutions.
Exercise protects against AMLN diet-induced lipid deposition in hepatocytes during MAFLD progression by regulating the UPRmt and FGF21 secretion
Authors: Yuan Xinmeng , Xiang Mengqi , Gao Yaran , Feng Wanyu , Sun Wen , Xu Ye , Zhang Liumei , Wu Jingyi , Tang Qiang , Lu Jiao , Zhang Yuan 
Published: May 2024

Abstract

Background
A high-calorie diet and lack of exercise are the primary risk factors contributing to metabolic associated fatty liver disease (MAFLD) initiation and progression. Although mitochondrial dysfunction in MAFLD has been widely recognized, the precise molecular mechanisms of mitochondrial function alteration during MAFLD development remain to be fully elucidated.
Methods
A total of sixty male C57/black mice were maintained on a normal or amylin liver NASH (AMLN) diet for 6 and 10 weeks. Half of the AMLN diet mice were then subjected to 8 weeks of voluntary wheel running with an AMLN diet persistently, while the other AMLN diet mice were sedentary until 14 and 18 weeks. After the experimental intervention, the mice were sacrificed under anesthesia, blood and liver tissue were collected for further analysis. Changes in biochemical parameters, histopathology, lipid accumulation, endoplasmic reticulum stress, mitochondrial function and mitochondrial unfolded protein response-related proteins were assessed and correlation analysis of serum FGF21 and mitochondrial unfolded genes expression was also performed.
Results
The results showed that the hepatic lipid deposition and PERK-eIF2α-ATF4 pathway activation were significant increased with prolonged duration of AMLN diet. However, expression of mitochondrial unfolded protein response (UPRmt) genes, such as LONP1, HSP60, and HSP70, as well as mitokine FGF21 secretion were significantly enhanced in the 14-week AMLN diet mice, but were markedly reduced with the excessive lipid deposition induced by the 18-week AMLN diet. In addition, there is a significant positive correlation between circulating FGF21 and the amount of mitochondrial unfolded genes expression during MAFLD progression. Moreover, exercise intervention significantly rescued the hepatic phenotype through improving mitochondrial function, regulating UPRmt activation pattern and increasing FGF21 secretion.
Conclusions
During the development of AMLN diet-induced MAFLD, the relationship between the degree of lipid deposition and mitochondrial function is not a linear model of negatively correlation. Instead, mitochondria could experience self-remodeling at the earlier stage of lipid accumulation, then lose their self-repair ability due to lipid overload. Exercise effectively prevents excessive lipid deposition, through regulating UPRmt, remodeling mitochondrial protein homeostasis and promoting the secretion of mitokine FGF21, which plays an essential role in delaying the MAFLD occurrence and progression.
Laterite used as pigment source- Analysis of Geological cum Anthropogenic specimen found in the Kaimur range, India through SEM-EDX and WD-XRF
Authors: Kumar Dharini , Sanyal Anindya , Rao Prof N.V Chalpathi , Prakash Rajiv , Tiwary Sachin Kumar 
Published: May 2024

Abstract

This study investigates the possible ancient colour extraction methods by analysing a sample from the Adhaura block rock shelters in Bihar's Kaimur Range. The sample was collected based on the assumption of being Haematite. To state factual evidence, it was then analysed using scanning electron microscopy (SEM) and energy dispersive X-rays (EDX) for a detailed study of its morphology and composition and wavelength dispersive X-ray fluorescence (WDXRF) to determine the elemental composition and presence of trace elements in the bulk rock. The results provide a new perspective on rock art colour schemes and enable a basic understanding of the geological nature of the landform. The sample analysis indicates that locally sourced materials, including a geological lateritic formation containing Haematite and Goethite in distinct phases, were used instead of the commonly used Haematite. This study bridges the need for scientific analysis in understanding the material and techniques in archaeology and anthropology. The results of these analyses provided a novel geological perspective for understanding rock art colour schemes and enabled a basic theoretical understanding of the rock art site and the geochemical nature of the landform. It also is an ensemble of technological investigations and natural science that helped achieve the results.
Determination of Optimal Concentration of the Plastifier (DIDP) for a PVC/ DIDP Industrial Formulation
Authors: bendjaouahdou Chaouki 
Published: May 2024

Abstract

The objectif of this work is to investigate the effects of the concentation of a plastifier, i.e, Di-Iso-Decyl-Phtalate (DIDP) on the properties of p ol yvi nyl chlor ide ( P V C) po l yme r u s ed i n t he fab r i ca tio n o f el ec tr i ca l cab l e s he at h. T he r e s u l t e d bl e nd ba s e d o n DIDP and P V C resin is prepared by dry blending followed by melt extrusion. The obtained results showed a decrease the tensile strength and shore A hardness when the amount of the used plastifier (DIDP) increases before and after thermal ageing. Furthermore, the strain at the break increases when the amount of the plastifier (DIDP) increases before and after thermal ageing. The thermal stability (deshydrochloration or Beilstein test) is maximal when the c o n cen t r at i o n of t he DIDP plastifier was equal to 45 wt. %.
Growth of the WTE industry in China and environmental performance
Authors: Ma Wenchao , Boré Abdoulaye , Cui Jicui , Huang Zhuoshi , Chen Guanyi , Themelis Nickolas J. 
Published: May 2024

Abstract

In the last twenty years, the waste-to-energy (WTE) capacity of China has become greater than any other nation. This study examines the environmental performance of the Chinese WTE power plants, including greenhouse gas (GHG), SO2, NOx, HCl, dioxins, particulate matter (PM), and heavy metal (HMs, 11 types) emissions, from 2005 to 2020. The results showed that GHG, NOx, and HCl national emissions increased with increasing WTE capacity. In contrast, PM, CO, SO2, and dioxins peaked in 2015 and gradually declined by 26%, 33%, 28%, and 82%, respectively, in 2020. MSW generation intensity, GDP per capita, and population were factors driving up pollutant emissions, whereas enhancing emission control and MSW treatment structure were key to lower emissions. Between 2005 and 2020, emission factors decreased by 22%-96%. Replacing landfilling by combustion with energy recovery (WTE) reduced the carbon footprint by 137 million tons of CO2-eq in 2020. Limiting emissions of PM, SO2, and NOx in line with the ultra-low emission (ULE) requirements can result in a yearly health benefit of US$18.4 million.
An Innovative Teaching &amp; Learning Paradigm to Enhance College Students’ Long-Term Memory &amp; Learning Gains
Authors: Warley Raquel 
Published: May 2024

Abstract

This article elaborates on the active ingredients and theory of change used to explain an innovative model of teaching and learning called MISSAL. MISSAL is an abbreviation for Meaningful Instruction, Social, Self-Regulated, and Active Learning. This learning intervention is in the third year of research and development. Drawing upon prior scholarly investigations on brain-based learning and various instructional strategies, the active ingredients of this framework are summarized. Using a sample of 12 undergraduate social work students, I examined to what extent the MISSAL approach facilitates short- and long-term knowledge retention and recall of acquired learning, successful exam performance, and learning gains among students enrolled in a content-intensive course. Findings of this preliminary investigation are hopeful. Implications for the higher education sector and future research are discussed.