bluuebunny/crossref_metadata_2025_split huggingface dataset:
ChemInform Abstract: 7‐Phenylplatensimycin (IIIa) and 11‐Methyl‐7‐phenylplatensimycin (IIIb): More Potent Analogues of Platensimycin
Authors: Jang Ki Po , Kim Chan Hyuk , Na Seong Wook , Jang Dong Seok , Kim Hiyoung , Kang Heonjoong , Lee Eun 
Published: August 2010

Abstractsynthesis of the title compounds (III) utilizing a carbonyl ylide cycloaddition strategy
ChemInform Abstract: Halogenated Analogues of 1′‐Acetoxychavicol Acetate, Rev‐Export Inhibitor from Alpinia galanga, Designed from Mechanism of Action.
Authors: Tamura Satoru , Shiomi Atsushi , Kimura Tominori , Murakami Nobutoshi 
Published: August 2010

AbstractA quinone methide intermediate is assumed to be essential for exerting the inhibitory activity of 1′‐acetoxychavicol acetate (ACA), the Rev‐export inhibitor from the medicinal plant Alpinia galanga.
ChemInform Abstract: Synthetic Studies on Natural Products. Part 73. Stereoselective Synthesis of Bioactive Natural Spiroacetals Aculeatins A and B.
Authors: Das Biswanath , Krishnaiah Martha , Sudhakar Chithaluri 
Published: August 2010

AbstractA new and efficient route to spiroacetals aculeatin A (VI) and B (VII) is presented.
ChemInform Abstract: The First F‐Ring Modified Ciguatoxin Analogue Showing Significant Toxicity.
Authors: Ishihara Yuuki , Lee Nayoung , Oshiro Naomasa , Matsuoka Shigeru , Yamashita Shuji , Inoue Masayuki , Hirama Masahiro 
Published: August 2010

AbstractThe total synthesis of a 10‐membered F‐ring analogue of 51‐hydroxyCTX3C is described which constitutes the first example of an F‐ring modified ciguatoxin that exhibits potent cytotoxicity as well as mouse acute toxicity.
ChemInform Abstract: Developing an Anion Host for Lipid A Binding and Antibacterial Activity.
Authors: Henderson Luke C. , Li Jian , Nation Roger L. , Velkov Tony , Pfeffer Frederick M. 
Published: August 2010

AbstractNew structural amphiphiles (I) bind the diphosphate lipid A anion and show potential as lead compounds for the development of novel antibacterial agents.
ChemInform Abstract: Catalytic Properties of Single Site Catalysts Prepared via Surface Organometallic Chemistry on Oxides and on Metals
Authors: Basset Jean‐Marie , Baudouin Anne , Bayard Francois , Candy Jean‐Pierre , Coperet Christophe , De Mallmann Aimery , Godard Gregory , Kuntz Emile , Lefebvre Frederic , Lucas Christine , et al. et al. 
Published: August 2010

AbstractReview: 118 refs.
First molecules, biological chirality, origin(s) of life
Authors: Caglioti Luciano , Micskei Károly , Pályi Gyula 
Published: August 2010

AbstractOrigin(s) of biological chirality appear(s) to be intimately connected to origin(s) of life. Prebiotic evolution toward these important turning points can be traced back to single chiral molecules. These can be small (monomeric) units as amino acids or monosaccharides or oligomers as oligo‐RNA type molecules. Earlier speculations about these two kinds of entries to biological chirality are critically reviewed. Chirality, 2011. © 2010 Wiley‐Liss, Inc.
Estimating chromatographic enantioselectivity (α) from gradient enantioselective chromatography data
Authors: Gong Xiaoyi , Craven Tim , Schafer Wes , Pirzada Zainab , Biba Mirlinda , Welch Christopher J. 
Published: August 2010

AbstractCalculation of chromatographic enantioselectivity (α) is critically important in enantioselective chromatographic method development studies. The fact that α can only be calculated from isocratic elution conditions, whereas gradient elution conditions are predominantly used in method development screening, presents some problems for the use of α as a scoring indicator for automated, intelligent enantioselective chromatography method development systems. In this study, an empirical algorithm was developed to estimate α at isocratic conditions based upon information collected from a gradient elution. The algorithm was validated for SFC applications and has been shown to accurately predict enantioselectivity for a wide variety of racemic test analytes eluted on different chiral column and mobile phase conditions. Chirality, 2011. © 2010 Wiley‐Liss, Inc.
Three‐dimensional direct simulation of a droplet impacting onto a solid sphere with low‐impact energy
Authors: Yan‐Peng Li , Huan‐Ran Wang 
Published: August 2010

AbstractIn this paper, a numerical model is developed for direct simulation of droplet impinging onto a spherical surface on a fixed Eulerian mesh. The model couples the level‐set method and the interfacial cell immersed boundary method to the single‐fluid formulation of the Navier–Stokes equations which are solved by a finite‐volume projection technique. Moving contact lines are modelled here with a simple static contact angle model. The model is shown to converge, and to agree with previous work in the literature. The model is then applied to investigate the impact behaviour of a droplet onto solid sphere of different diameters at low Weber number and low Reynolds number. The simulation results show that the droplet used in present study seems to deposit on different spherical surfaces through oscillating. The simulated results also suggest that the impacted‐sphere size has a significant effect on the impact dynamics of the droplet. A local breakage phenomenon may be found in the centre of the droplet collision with a smaller sphere during the first recoiling stage. A regime map is then established to provide quantitative analysis for the breakage mode of the current impacting process.
Sorafenib in patients with metastatic renal cell carcinoma refractory to either sunitinib or bevacizumab
Authors: Garcia Jorge A. , Hutson Thomas E. , Elson Paul , Cowey C. Lance , Gilligan Timothy , Nemec Cheryl , Dreicer Robert , Bukowski Ronald M. , Rini Brian I. 
Published: August 2010

AbstractBACKGROUND:Bevacizumab and sunitinib are standard initial therapy in metastatic renal cell carcinoma (mRCC). Despite common use, the safety and activity of sorafenib in bevacizumab‐ or sunitinib‐refractory mRCC have not been prospectively investigated.METHODS:Metastatic RCC patients with Response Evaluation Criteria in Solid Tumors (RECIST)‐defined disease progression (PD) after treatment with either bevacizumab or sunitinib received twice daily 400 mg of sorafenib in a multicenter, prospective phase 2 study. Dose escalation was permitted in the absence of significant toxicity. The primary endpoint was tumor burden reduction rate, defined as the proportion of patients with ≥5% reduction in the sum of RECIST‐defined target lesions without other PD. Secondary endpoints included progression‐free survival (PFS), duration of response, overall survival, and safety. A 2‐stage accrual design was used to test the alternative hypothesis that the tumor burden reduction rate was >20% versus <5%.RESULTS:Forty‐eight patients were enrolled. The tumor burden reduction rate was 30% (95% confidence interval [CI], 17%‐45%). One unconfirmed objective partial response was observed. The median PFS was 4.4 months (95% CI, 3.6‐5.9). There was no association of PFS and tumor shrinkage with response to prior therapy. Most treatment‐related adverse events were of mild‐to‐moderate intensity, and included fatigue, hypertension, diarrhea, and palmoplantar erythrodysesthesia (PPE). Patients previously treated with bevacizumab tended to develop more PPE (P = .03) and mucositis (P = .06), whereas sunitinib‐treated patients tended to develop more skin rash (P = .06).CONCLUSIONS:Administration of sorafenib is safe and feasible in patients with mRCC refractory to either bevacizumab or sunitinib. Modest clinical activity was observed supporting current practice patterns of sequential vascular endothelial growth factor‐targeted therapy in mRCC. Cancer 2010. © 2010 American Cancer Society.
Endoscopic esophageal tumor length
Authors: Gaur Puja , Sepesi Boris , Hofstetter Wayne L. , Correa Arlene M. , Bhutani Manoop S. , Watson Thomas J. , Swisher Stephen G. ,   Members of the M. D. Anderson Esophageal Cancer Group and the University of Rochester School of Medicine and Dentistry Foregut Group
Published: August 2010

AbstractBACKGROUND:Pathologic esophageal tumor length (pL) is an independent predictor of long‐term survival. However, whether patients with longer (high‐risk) tumors can be identified by endoscopy before surgery has not been established. The objective of the current study was to determine the value of endoscopically measured tumor length (cL) in predicting overall survival in patients with esophageal adenocarcinoma.METHODS:All patients with esophageal adenocarcinoma who had undergone resection without neoadjuvant therapy and who had documented preoperative endoscopy findings were identified retrospectively by using prospectively collected databases at 2 institutions: The University of Texas M. D. Anderson Cancer Center (n = 164; training set) and University of Rochester Medical Center (n = 109; validation set). Esophageal tumors were assessed preoperatively by endoscopy for cL, depth (cT), and lymph node involvement (cN). Univariate and multivariate analyses of cL and other standard prognostic factors were performed.RESULTS:In the training set, cL was correlated directly with pL (Pearson correlation [r] = 0.683;P< .001). Regression tree analyses suggested an optimum cutoff point of cL >2 cm to identify patients with decreased long‐term survival (5‐year survival rate: cL >2 cm, 29%; cL ≤2 cm, 78%;P< .001). Multivariate Cox regression analysis demonstrated that cL >2 cm was an independent risk factor for long‐term survival (hazard ratio, 2.3; 95% confidence interval, 1.1‐4.4;P= .02) even after controlling for age, cT, and cN. Validation with the validation dataset confirmed that cL was correlated directly with pL (r= 0.657;P< .001) and predicted long‐term survival using a cL cutoff point of >2 cm (hazard ratio, 2.8; 95% confidence interval, 1.4‐5.8;P= .004; univariate analysis).CONCLUSIONS:Endoscopic esophageal tumor length was identified as an independent predictor of long‐term survival and may help to identify high‐risk patients before they receive cancer‐directed therapy. Cancer 2011. © 2010 American Cancer Society.
Incorporating fertility preservation into the care of young oncology patients
Authors: Redig Amanda J. , Brannigan Robert , Stryker Steven J. , Woodruff Teresa K. , Jeruss Jacqueline S. 
Published: August 2010

AbstractAs the number of cancer survivors continues to increase, oncologists are faced with the challenge of providing cancer therapy to patients who may 1 day want to have children. Yet, gonadotoxic cancer treatments can compromise future fertility, either temporarily or permanently. There are established means of preserving fertility before cancer treatment; specifically, sperm cryopreservation for men and in vitro fertilization and embryo cryopreservation for women. Several innovative techniques are being actively investigated, including oocyte and ovarian follicle cryopreservation, ovarian tissue transplantation, and in vitro follicle maturation, which may expand the number of fertility preservation choices for young cancer patients. Fertility preservation may also require some modification of cancer therapy; thus, patients' wishes regarding future fertility and available fertility preservation alternatives should be discussed before initiation of therapy. This commentary provides an overview of the range of fertility preservation options currently available and under development, using case‐based discussions to illustrate ways in which fertility preservation can be incorporated into oncology care. Cases involving breast cancer, testicular cancer, and rectal cancer are described to illustrate fertility issues experienced by male and female patients, as well as to provide examples of strategies for modifying surgical, medical, and radiation therapy to spare fertility. Current guidelines in oncology and reproductive medicine are also reviewed to underscore the importance of communicating fertility preservation options to young patients with cancer. Cancer 2011. © 2010 American Cancer Society.
Clinical impact of amphiregulin expression in patients with epidermal growth factor receptor (EGFR) wild‐type nonsmall cell lung cancer treated with EGFR‐tyrosine kinase inhibitors
Authors: Chang Myung Hee , Ahn Hee Kyung , Lee Jeeyun , Jung Chan‐Kwon , Choi Yoon‐La , Park Yeon Hee , Ahn Jin Seok , Park Keunchil , Ahn Myung‐Ju 
Published: August 2010

AbstractBACKGROUND:In patients with nonsmall cell lung cancer (NSCLC), several studies have demonstrated a positive correlation between somatic mutation in the epidermal growth factor receptor (EGFR) tyrosine kinase domain and clinical outcomes with the use of EGFR tyrosine kinase inhibitors (TKIs). However, some patients with wild‐type (WT) EGFR also responded to EGFR TKIs and remained stable. Recently, amphiregulin (AR) has been suggested as a predictive marker for EGFR TKIs in patients with WT EGFR‐positive NSCLC. The objective of the current study was to evaluate the association between AR expression and the efficacy of using EGFR TKIs in the treatment of patients with WT EGFR‐positive NSCLC.METHODS:Seventy‐three patients with WT EGFR‐positive NSCLC received treatment with gefitinib or erlotinib between May 2005 and December 2008. AR expression was assessed by immunohistochemistry.RESULTS:The clinical response to EGFR TKIs was reassessed for all patients as follows: 16 of 73 patients had a partial response (21.9%), 12 patients had stable disease (16.5%), and 45 patients had progressive disease (61.6%). AR expression was positive in 24 of 40 patients (60%). The ability to achieve disease control did not differ significantly between AR‐positive patients and AR‐negative patients (P = .188). At a median follow‐up of 25.4 months (range, 10.5‐53.3 months), progression‐free survival was 8.1 weeks in AR‐positive patients and 4 weeks in AR‐negative patients (P = .025), and overall survival was significantly longer in AR‐positive patients than in AR‐negative patients (12.2 months vs 4.1 months; P = .001).CONCLUSIONS:The current results suggested that patients with WT EGFR‐positive NSCLC who have AR‐positive tumors may benefit clinically from treatment with EGFR TKIs, indicating that AR expression may be a potential marker for the selection of EGFR‐TKI treatment for patients with WT EGFR‐positive NSCLC. Cancer 2011. © 2010 American Cancer Society.
Cytologic diagnosis and differential diagnosis of lung carcinoid tumors a retrospective study of 63 cases with histologic correlation
Authors: Stoll Lisa Marie , Johnson Michael W. , Burroughs Frances , Li Qing Kay 
Published: August 2010

AbstractBACKGROUND:Neuroendocrine (NE) neoplasms of the lung are a spectrum of tumors including typical carcinoid (TC), atypical carcinoid tumor (ACT), small cell lung carcinoma (SCLC), and large cell NE carcinoma (LCNEC). Given the overlapping features within these tumors, misclassification is a known risk, with significant treatment consequences.METHODS:A search of the pathology archives from The Johns Hopkins Hospital yielded 390 cases of TC diagnosed over 20 years. Sixty‐three cytology cases with corresponding surgical material were identified. The cytology specimens were comprised of 49 cases of lung fine‐needle aspiriation specimens and 14 cases of lung brushings/washings.RESULTS:Among 63 paired cases, 32 cases (51%) demonstrated concordant and 31 cases (49%) demonstrated discordant diagnoses. Among discordant cases, the most notable findings included overdiagnosis of TC as SCLC (4 cases; 6%), ACT (4 cases; 6%), and poorly differentiated carcinoma with NE features (5 cases; 8%) as well as misdiagnosis of other lesions as TC (4 cases; 6%) on cytology.CONCLUSIONS:The significant morphologic factors for distinguishing low‐grade TC from ACT, SCLC, or carcinoma remain the critical evaluation of nuclear features, chromatin patterns, and assessment of nucleoli. Nuclear molding and crowding are not discernible features because they may be found on smears with increased cellularity. Crush artifact can occur in both low‐grade and high‐grade NE neoplasms and may cause a misinterpretation of SCLC. Other artifacts resulting from delayed fixation or poor processing and sampling error are potential causes of incorrect interpretations. Ki‐67 staining may be useful in difficult cases. Cancer (Cancer Cytopathol) 2010. © 2010 American Cancer Society.
Effects of natural convection within the anterior chamber on the ocular heat transfer
Authors: Ooi E. H. , Ng E. Y. K. 
Published: August 2010

AbstractThe aqueous humor inside the anterior chamber has been known to be in constant circulation. It is widely accepted that this flow is caused mainly by the thermal gradient inside the anterior chamber, which induces buoyancy. This generates natural convection inside the anterior chamber, which may affect the overall heat transfer inside the human eye. Nevertheless, most of the studies in the past that investigated the temperature distribution inside the human eye have not included this into their mathematical model. This study seeks to investigate the significance of natural convection inside the anterior chamber on the heat transfer inside the human eye. For this purpose, a two‐dimensional model of the anterior chamber is developed using the boundary element method. Copyright © 2010 John Wiley & Sons, Ltd.
Cyber Physical Socio Ecology
Authors: Shi Xiaoqing , Zhuge Hai 
Published: August 2010

AbstractExploring the laws of the nature and the rules of human society is the grand challenge of sciences. The Internet, Web, various communication networks and digital devices are connecting each other to form an enormous cyber space. The cyber space gradually connects the natural physical space via various cyber‐physical interfaces to form Cyber Physical Systems. Interacting with humans, Cyber Physical Systems will connect human society to form a new world—Cyber Physical Society. Humans' daily life and work will become increasingly relying on the new world. Billions of years' evolution creates the most elegant and efficient natural ecosystem. It will be ideal if the Cyber Physical Society can be an ecosystem that harmoniously evolves with society, economy, culture, sciences and technologies. The natural ecosystem gives us inspiration to ensure the harmony of the Cyber Physical Society. From ecosystem point of view, this paper proposes the notion, method, scientific issues, general architecture and resource management of Cyber Physical Society. The study of the Cyber Physical Socio Ecology (CPSE) could lead to a new branch of sciences. Copyright © 2010 John Wiley & Sons, Ltd.
Assessing service protocol adaptability based on protocol reduction and graph search
Authors: Zhou Zhangbing , Bhiri Sami , Zhuge Hai , Hauswirth Manfred 
Published: August 2010

AbstractGiven the inherent autonomy, heterogeneity, and continuous evolution of Web services, mismatches usually exist between service protocols. Adapters are typically used to reconcile these mismatches. Before synthesizing an adapter, a service requestor is often willing to assess whether her expected interactions can be conducted or not. The effort of synthesizing an adapter is beneficial only if the result of this assessment is positive. Previous effort analyzing service interactions focused on either (i) compatibility analysis for checking whether interactions can be conducted in a direct manner or (ii) adapter synthesization for reconciling mismatches. In this paper we propose a new kind of adaptability assessment that (i) determines whether two service protocols of a requestor and a provider are adaptable, (ii) computes an adaptation degree, and (iii) identifies conditions that determine when these two service protocols can be adapted. This adaptability assessment provides complementary criteria to the service requestor for selecting a suitable service protocol from a set of functionally equivalent candidates according to her requirements. Copyright © 2010 John Wiley & Sons, Ltd.
Energy‐aware scheduling of bag‐of‐tasks applications on master–worker platforms
Authors: Pineau Jean‐François , Robert Yves , Vivien Frédéric 
Published: August 2010

AbstractWe consider the problem of scheduling an application composed of independent tasks on a fully heterogeneous master–worker platform with communication costs. We introduce a bi‐criteria approach aiming at maximizing the throughput of the application while minimizing the energy consumed by participating resources. Assuming arbitrary super‐linear power consumption laws, we investigate different models, with energy overheads and memory constraints. Building upon closed‐form expressions for the uni‐processor case, we derive asymptotically optimal solutions for all models. Copyright © 2010 John Wiley & Sons, Ltd.
Kinetics and Mechanisms for the Reactions of Ozone with Unsaturated Oxygenated Compounds
Authors: Al Mulla Ismael , Viera Lisa , Morris Rebecca , Sidebottom Howard , Treacy Jack , Mellouki Abdelwahid 
Published: August 2010

AbstractRate coefficients for the reaction of ozone with a series of unsaturated oxygenated compounds are determined in air at atmospheric pressure and (298±3) K. Rate data are obtained using both relative and absolute rate techniques, and the measured rate coefficients are found to be in good agreement. The results show that the reactivity of the compounds with respect to addition of ozone to the double bond is a function of the nature of the oxygenated substituent. Product distribution studies on the reactions provide information on the decomposition pathways for the primary ozonides, and on the effect of the oxygenated group on the relative importance of the degradation pathways. The results are discussed in terms of their importance in the atmospheric oxidation of unsaturated oxygenated compounds.
Metal‐Free Porphyrin‐Sensitized Mesoporous Titania Films For Visible‐Light Indoor Air Oxidation
Authors: Ismail Adel A. , Bahnemann Detlef W. 
Published: August 2010

AbstractTransparent cubic mesoporous TiO2 films coated on soda‐lime glass have been developed. A metal free meso‐tetrakis(4‐sulfonatophenyl) porphyrin (TPPS) has been adsorbed on these TiO2 films from aqueous solutions. The results indicated that the obtained mesoporous TiO2 and 3D TPPS/TiO2 films are optically transparent and crack free (thickness ca. 200±20 nm). The introduction of the TPPS molecules has only a very small influence on the pore system and some limited pore blocking seems to occur. Transmission electron microscopy (TEM) images revealed that the adsorption of TPPS does not disrupt the meso order of TPPS/TiO2. The particle size of these TiO2 nanocrystals has been measured to be approximately 5–8 nm. TPPS/TiO2 photocatalysts, exhibiting regularly ordered mesopores, large surface area (ca. 102.5 cm2 cm−2), and specific pore volume of about 0.1 mm3 cm−2, show improved light‐harvesting efficiency as compared with other transparent TiO2 films. Employing the 3D TPPS/TiO2 photocatalyst, a quantum efficiency of 0.059 % has been obtained for the photodegradation of CH3CHO in the gas phase under visible‐light illumination. Recycling tests demonstrated that the newly synthesized photocatalyst was quite stable during this gas–solid heterogeneous photocatalytic process because no significant decrease in photocatalytic activity was observed even after being used repetitively up to five times. Therefore, the newly synthesized transparent 3D TPPS/TiO2 photocatalysts can potentially be applied for low‐cost air purification and self‐cleaning applications.