bluuebunny/crossref_metadata_2025_split huggingface dataset:
Methamphetamine self-administration causes neuronal dysfunction in rat medial prefrontal cortex in a sex-specific and withdrawal time-dependent manner
Authors: Chen Lihua , Kreko-Pierce Tabita , Cassoday Stefanie L. , Al-Harthi Lena , Hu Xiu-Ti 
Published: February 2025

Methamphetamine (Meth) is one of the most widely used illicit drugs worldwide, exerting potent psychostimulant effects that fuels its highly addictive nature. Chronic Meth use is associated with severe cognitive impairments, particularly in executive functions, decision-making, and working memory, which persist long even after cessation of Meth use. These cognitive deficits are associated with dysfunction of glutamatergic pyramidal neurons in the medial prefrontal cortex (mPFC), which regulates addiction and cognition. Both human and animal studies highlight Meth-induced mPFC dysfunction that contributes to compulsive behaviors and relapse. Emerging evidence also highlights significant sex differences in Meth use disorder (MUD). Previous studies suggest that Meth-induced behavioral and neuronal dysfunctions are different between males and females, but the cellular and molecular mechanism are not fully understood. Using behavioral and electrophysiological approaches (whole-cell patching), this study determined certain sex differences in neuronal dysfunction in the mPFC of rats that self-administered Meth (Meth-SA) followed by a short (2–5 d) or long-term (≥30 d) withdrawal. We found that both male and female rats self-administered methamphetamine in a similar pattern; however, the resulting hypoactivity, hyperactivity, and calcium dysregulation in mPFC neurons differed between the sexes. Such sex-specific neuronal dysfunction was associated with, and depended on, short or long-term withdrawal, respectively. By understanding these sex-specific behavioral/neuronal differences following different Meth withdrawal period, our novel findings demonstrate the role of sex as a biological variable in Meth-use and relapse, and reveal the effects of drug-using environment on mPFC neuronal dysfunction during withdrawal, providing insights for gender-specific treatment strategies.
Cinnamic acid alleviates hypertensive left ventricular hypertrophy by antagonizing the vasopressor activity and the pro-cardiac hypertrophic signaling of angiotensin II
Authors: Cui Yimeng , Yang Yawei , Tang Xinmiao , Wang Peiwei , Cui Jingang , Chen Yu , Zhang Teng 
Published: February 2025

BackgroundHypertension is the most common cause of pathological left ventricular hypertrophy, a condition causally associated with debilitating heart failure and cardiovascular events in hypertensive patients. It is well recognized that the disease burden of hypertension-linked heart failure remains unabated with existing treatments. New therapies controlling hypertensive left ventricular hypertrophy are thus required to decelerate or prevent the development of heart failure. Our previous study has demonstrated that cinnamic acid, a naturally occurring monocarboxylic acid, mitigates transverse aortic constriction-induced pressure overload-mediated cardiac hypertrophy. However, whether cinnamic acid is effective at controlling hypertensive left ventricular hypertrophy remains unknown. Angiotensin II (ang II) plays a pivotal role in driving the pathogenesis of hypertensive left ventricular hypertrophy. The current work thus investigates the therapeutic potential and pharmacological mechanisms of cinnamic acid in the context of ang II-mediated hypertensive left ventricular hypertrophy.MethodsAng II-infused mice and cardiomyocytes were analyzed by histological, immunohistochemical, cellular and molecular biological methods to delineate the impact of cinnamic acid on hypertensive left ventricular hypertrophy.ResultsThe results showed that cinnamic acid lowered blood pressure and attenuated left ventricular hypertrophic and fibrotic alterations in the ang II-infused mice. Cinnamic acid counteracted hypertrophic responses, impairment of the mitochondrial function and overproduction of mitochondrial reactive oxygen species (ROS) in the cardiomyocytes exposed to ang II. At the molecular level, cinnamic acid mitigated ang II-induced activation of signal transducer and activator of transcription 3 (STAT3) and extracellular signal-regulated kinase 1/2 (ERK1/2) in cardiomyocytes. Additionally, cinnamic acid blunted STAT3 and ERK1/2 activation as well as the hypertrophic responses in cardiomyocytes exposed to interleukin 6 (IL-6) as well.ConclusionIn summary, this is the first study demonstrating that cinnamic acid is effective at mitigating hypertensive left ventricular hypertrophy. Cinnamic acid antagonizes the vasopressor activity of ang II at the systemic level and the ligand-dependent pro-hypertrophic signaling of ang II in cardiomyocytes. Furthermore, our present study presents new evidence supporting that cinnamic acid lessens the activation of STAT3 and ERK1/2, which may in part contribute to its anti-hypertrophic actions in cardiomyocytes.
A scoping review of longitudinal studies of athlete burnout
Authors: Dišlere Beate Evelīna , Mārtinsone Kristīne , Koļesņikova Jeļena 
Published: February 2025

IntroductionPrior research has shown that increasing training and competition loads, along with associated stressors, can negatively impact athletes’ mental health and contribute to burnout. While athlete burnout can be associated with various negative sports-related consequences, such as withdrawal from sports or injuries. Although most studies on athlete burnout employ cross-sectional designs, longitudinal approaches could provide valuable insights into athlete burnout changes over time and potential causal relationships between variables and burnout. Therefore, this study aims to systematically examine longitudinal design studies to offer a comprehensive methodological, conceptual, and practical overview of athlete burnout and its associated factors.MethodsFollowing PRISMA-ScR guidelines, this review explores what factors influence changes in burnout levels among athletes throughout a sports season. Therefore, studies were selected that examined athlete burnout across both genders, all age groups, and various sport types, using repeated measurements. Published articles from 2014 to 2024 were collected. Eligible studies were identified through three databases: PubMed, Scopus, and Web of Science.ResultsA total of 32 studies were analyzed. Quantitative mapping highlights study demographics, measurement approaches, and procedures, while qualitative mapping identifies 26 factors categorized as risk, protective, and factors influenced by burnout. The review highlights the use of tools like the Athlete Burnout Questionnaire and identifies optimal data collection intervals for tracking burnout dynamics.ConclusionThis scoping review offers insights into the multidimensional and nonlinear nature of athlete burnout, emphasizing its development through longitudinal studies and the importance of monitoring specific dimensions. The findings revealed various athlete burnout influencing personal and sport-environmental factors, including risk factors like perfectionistic concerns and negative social interaction, protective factors such as resilience-related skills and relatedness, and social support. The study emphasizes the importance of early detection and longitudinal monitoring to prevent burnout and mitigate its impact on athletes’ mental health and performance. Further research is needed to explore additional risk and protective factors to develop effective interventions aimed at reducing the risk of burnout in athletes.
Global burden and international disparities in NASH-associated liver Cancer: mortality trends (1990–2021) and future projections to 2045
Authors: Nie Qilong , Jiang Yongwen , Li Mingyang , Liang Qiuyan , Mo Xiaoai , Qiu Tengyu , Jiang Qunfang , Huang Kaizhou , Xie Youqing , Chen Ying , Ma Xiaojun , Li Jianhong , Jiang Kaiping 
Published: February 2025

BackgroundNASH-associated liver cancer (NALC) is a significant contributor to global cancer mortality, closely linked to the increasing prevalence of non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH). This study comprehensively examines the global burden of NALC from 1990 to 2021.MethodsThis study used data from the Global Burden of Disease (GBD) 2021 database to analyze NALC death and age-standardized death rates (ASDR) globally and regionally from 1990 to 2021. We applied Joinpoint regression analysis to assess temporal trends, calculating the annual percent change (APC) and average annual percent change (AAPC). Decomposition analysis was performed to break down mortality changes into contributions from population aging, growth, and epidemiological changes. A frontier analysis was used to evaluate the relationship between NALC burden and sociodemographic development using the Socio-Demographic Index (SDI). Prediction analysis of NALC deaths and ASDR from 2021 to 2045 were estimated using the Nordpred model.ResultsFrom 1990 to 2021, the global burden of NALC deaths increased significantly, with the ASDR rising from 0.38 per 100,000 in 1990 to 0.48 per 100,000 in 2021. Age-specific data in 2021 revealed that NALC deaths peaked in the 65–69 age group for men and 70–74 age group for women. Decomposition analysis indicated that population growth was the most significant contributor to the global NALC death toll, followed by population aging and epidemiological changes. Frontier analysis showed that countries like Mongolia and Gambia were farthest from the disease burden frontier, while Morocco and Ukraine were closest. Prediction analysis suggest a significant increase in NALC deaths by 2045 compared to 2021, with a larger rise in deaths among women.ConclusionThrough this study, a data-driven approach is provided to reduce the global disease burden of NALC. Essential data support for public health prevention strategies is offered, helping guide the development of targeted government interventions. Trends across global regions, countries, age groups, and genders have been analyzed, providing valuable insights for the formulation of evidence-based policies aimed at mitigating the impact of NALC worldwide.
“Know your medicines, know your health”—public perspectives on medicines and health awareness campaigns
Authors: Alhomoud Faten , Alameer Kawthar , Almousa Zahra’a , Almatar Manar , Alzlaiq Wafa , Alhomoud Farah Kais , Alsugeir Dana 
Published: February 2025

BackgroundIrrational medication use is likely to result in therapeutic failure and disease progression. One way to increase public awareness about appropriate medication use is to design and deliver a public health medicine awareness campaign. This study aims to assess the public’s attitudes and experiences related to medication use and health awareness campaigns in Saudi Arabia.MethodsThis is a cross-sectional survey study. Participants were aged 18 or over and able to speak Arabic or English. An online survey was distributed to a convenient sample of 451 participants by email and social media via an internet link, leading to a web-based survey platform in QuestionPro. Bivariate and multivariate analyses were used to assess the associations.ResultsThree hundred and forty-seven participants (76% female, aged 18–85 years) were on a mean (SD) of two (1.86) prescription-only-medicines (POMs), and 225 were on non-prescription medicines. Seventy-one and 63 % of those surveyed consulted a doctor or a pharmacist, respectively, for advice about their medications. The participants were curious mainly about the side effects of treatment (79%), followed by drug interactions and contraindications (55%). Most participants agreed or strongly agreed that their medications were necessary to improve their condition (82%), prevent the progress of their condition (85%), and reduce the risk of complications (90%). Seventy-seven percent of participants reported seeing a public health campaign previously. TV (58%) and Twitter (55%) were reported as the most appropriate tools to help deliver a good public health campaign. Ninety-one percent believed that a public health campaign can increase people’s awareness about their lifestyle, and 73% declared that medication should be part of it.ConclusionThe findings can be a foundation for developing and implementing medicines and health awareness campaigns to enhance public understanding of health and medication use.
“They seemed to forget about us little people”: the lived experiences of personal care attendants during the COVID-19 pandemic
Authors: Wendel Carrie , Sullivan Darcy L. , Babitzke Jennifer , La Pierre Tracey A. 
Published: February 2025

BackgroundPersonal care attendants (PCAs) provided essential care and support to home care clients during the COVID-19 pandemic and thus were a vital part of the pandemic response in helping to keep older adults and individuals with disabilities out of nursing homes. Furthermore, they are one of the largest and fastest growing workforces in the United States. Yet this essential workforce received little attention during the pandemic. Guided by feminist theories on caregiving and the principles of community-based participatory research, this study examined the experiences of PCAs during the COVID-19 pandemic.MethodsData from 78 in-depth interview participants representing Medicaid-Funded Home and Community-Based Services (HCBS) PCAs, clients, family caregivers, and service providers in Kansas, United States, as well as additional data from 176 PCA survey participants were analyzed. Findings from this interactive, convergent, mixed-methods study were integrated by theme using the weaving approach.ResultsFour major themes emerged from the analysis: (1) PCAs remained in this field during the pandemic out of a commitment to their clients; (2) PCAs were undervalued and invisible as an essential workforce; (3) direct care work had an emotional toll on PCAs during the pandemic; and (4) PCAs have mixed feelings about their satisfaction with the job, and, as good workers quit, they were difficult to replace.DiscussionPCAs held professional-level responsibilities without the recognition or pay of a professional. The pandemic had mixed impacts on job stress and satisfaction, suggesting that the intrinsic rewards of the job and social support had a protective impact. However, intrinsic rewards are not enough to retain this workforce, and the growing PCA workforce shortage leaves many clients having to choose between no care and poor care. Our findings indicate that institutions and systems must better support and recognize this essential workforce to build and maintain a quality in-home care services system.
Er(III) and Yb(III) Complexes with a Tripodal Nitroxyl Radical: Magnetochemical Study and Ab Initio Calculations
Authors: Perfetti Mauro , Dmitriev Alexey A. , Vostrikova Kira E. 
Published: February 2025

In this paper, we investigate the magnetic exchange interaction and magnetization dynamics of two new members of the [LnRad(NO3)3] family, where Rad is a tripodal nitroxide, and Ln is Er(III) or Yb(III), having the prolate type electron density. Single OK crystal and powder X-ray diffraction studies showed that these complexes are isostructural with their previously investigated Y, Gd, Dy, Tm, Tb, Eu, and Lu congeners. A magnetometric investigation, supported by ab initio calculations, showed the presence of antiferromagnetic coupling between the lanthanide ion and the radical in both compounds with estimated J values of ≈7 and ≈20 cm−1 for Er and Yb, respectively (+J Seff∙ S formalism).
Effect of pulse repetition frequency on efficiency of tissue erosion in histotripsy with ultrasonic focus scanning in the direction of propagation
Authors: Takahashi Kazuki , Mori Shohei , Yoshizawa Shin 
Published: February 2025

Abstract
Histotripsy is a non-invasive treatment method that mechanically destroys soft tissues using cavitation bubbles generated by high-intensity focused ultrasound (HIFU) sonication. Our previous study suggested that scanning the HIFU focus in the opposite direction of propagation could improve the time efficiency of shock scattering histotripsy. In this paper, we extend the method by increasing the number of focus scanning and experimentally investigate the dependence of treatment efficiency of the method on the pulse repetition frequency (PRF) of HIFU sonication. The results showed that the energy efficiency of treatment at high PRF decreased as the number of focal scans increased. This observation may be explained by the greater influence of residual bubbles, suggesting that the optimal number of focus scanning for maximizing treatment efficiency depends on the PRF.
Development and evaluation of Dona, a privacy-preserving donation platform for messaging data from WhatsApp, Facebook, and Instagram
Authors: Hakobyan Olya , Hillmann Paul-Julius , Martin Florian , Böttinger Erwin , Drimalla Hanna 
Published: February 2025

Abstract
Social interactions are a fundamental aspect of human life, yet, their objective and naturalistic measurement remains challenging for scientific research. This challenge can be addressed using digital communication data. To this end, we have developed Dona, an open-source platform for donating messaging data from WhatsApp, Facebook, and Instagram. Given the highly sensitive nature of messaging data, we ensure participant privacy through rigorous data minimization. Dona removes all sensitive information on the user side prior to donation, retaining only de-identified meta-data such as message length and timestamps. This paper presents an overview of the platform, a deployment guide, and example use cases. In addition, we evaluate the informativeness of minimized messaging data for studying social interactions with two approaches. First, we conducted a user study in which 85 participants donated their data, received visualizations of their messaging behavior and evaluated the informativeness of this visual feedback. Second, we performed a quantitative analysis using over 1500 donated chats to confirm whether minimized messaging data captures known aspects of human interactions, such as interaction balance, heterogeneity, and burstiness. The results demonstrate that minimized, de-identified messaging data reflects informative interaction features as assessed by both self-reports and objective metrics. In conclusion, Dona is a donation platform well suited for sensitive contexts in which researchers aim to balance participant privacy with the acquisition of objective and informative data on social interactions.
Enfoque del Cuidado de Enfermería para la Atención de Pacientes Embarazadas con Preeclampsia en el Servicio de Emergencia del Hospital Gineco Obstétrico Pediátrico Nueva Aurora
Authors: Llumitaxi Pilco Liliana Elizabeth , Inés Patricia Urgilés Vallejo 
Published: February 2025

Introducción: La preeclampsia es una complicación médica grave que puede surgir durante el embarazo y que requiere una atención especializada para garantizar la salud tanto de la madre como del feto. Dentro de este campo, el enfoque del cuidado de enfermería para las pacientes embarazadas con preeclampsia es fundamental para estabilizar el cuadro clínico y evitar complicaciones. Objetivo: Explorar desde la visión de las/os profesionales de enfermería el enfoque del cuidado utilizado por la disciplina para la atención de pacientes embarazadas con preeclampsia en el Área de Emergencia Obstétrica del Hospital Gineco-Obstétrico Luz Elena Arismendi. Materiales y métodos: La investigación tuvo un enfoque cualitativo, de diseño fenomenológico e incluyó a 15 profesionales de enfermería del Área de Emergencia Obstétrica del Hospital Gineco-Obstétrico Luz Elena Arismendi con una experiencia laboral de al menos 6 meses. Como técnica de recolección se utilizó una entrevista basada en un cuestionario estructurado acorde a las cuatro categorías de análisis. Resultados: acorde a los resultados obtenidos, los profesionales de enfermería del área de emergencia cuentan con vastos conocimiento y habilidades teórico-prácticas para el abordaje de la preeclampsia, en esta se incluye el control estricto de signos vitales e impregnación de sulfato de magnesio como medidas de primera línea. A más de ello, la aplicación de valores humanos y relación de ayuda resultaron primordiales. Conclusión: el enfoque del cuidado utilizado para la atención de pacientes embarazadas con preeclampsia en el Área de Emergencia Obstétrica del Hospital Gineco-Obstétrico Luz Elena Arismendi es integral por cuanto integra la evidencia científica de protocolos oficialmente reconocidos y a la vez el humanismo, empatía, compasión, respeto y ayuda para una adecuada satisfacción de necesidades físicas y mentales en la gestante preeclampsia.
Resolving Pleiades Binary Stars with Gaia and Speckle Interferometric Observations
Authors: Chulkov Dmitry , Strakhov Ivan , Safonov Boris 
Published: February 2025

Abstract
The Pleiades is the most prominent open star cluster visible from Earth and an important benchmark for simple stellar populations unified by common origin, age, and distance. Binary stars are its essential ingredient, yet their contribution remains uncertain due to heavy observational biases. A resolved multiplicity survey was conducted for a magnitude-limited G < 15mag sample of 423 potential cluster members, including sources with poorly fitted astrometric solutions in Gaia DR3. Speckle interferometric observations at the 2.5 m telescope of the Sternberg Astronomical Institute, Moscow State University observatory were combined with Gaia data, enabling the identification of 61 resolved binary or multiple systems within the 0

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04–10″ (5–1350 au) separation range. With speckle observations, we discovered 21 components in 20 systems. The existence of a Merope (23 Tau) companion is confirmed after several previous unsuccessful attempts. We show that the Gaia multipeak fraction is a strong predictor of subarcsecond multiplicity, as all sources with ipd_frac_multi_peak > 4% are successfully resolved. We found that 10% of Pleiades stars have a companion with a mass ratio q > 0.5 within the projected separation of 27 < s < 1350 au, and confirm a deficit of wide binaries with s > 300 au. An observed dearth of wide pairs with a large mass ratio (q > 0.55) may imprint the transition from hard to soft binaries regime at the early stages of cluster evolution. The total binary fraction for q > 0.5 systems is extrapolated to be around 25%.