bluuebunny/crossref_metadata_2025_split huggingface dataset:
How do both firm‐level resources and country‐level competitiveness shape the relationship between alliance portfolio diversity and radical innovation? A comparison between the food and other manufacturing industries
Authors: Ancín María , Zouaghi Ferdaous , Sánchez Mercedes 
Published: May 2024

AbstractThis study examines how European food companies can operationally leverage the value created by strategic alliances into commercially viable products. More importantly, it emphasizes that the effects of alliance portfolio diversity (APD) on radical innovation performance can be achieved not only directly, but also via moderating roles, that is, the firm's social capital and the level of competitiveness of the country. Using three waves of the European Community Innovation Survey, our results show that the optimal level of APD varied depending on the industry in which the company operates (food manufacturing industry vs. the rest of manufacturing industries). Furthermore, social capital seems to be a crucial factor to mitigate the difficulties of leveraging very diverse knowledge from partners, especially in the food manufacturing industry. Moreover, the external environmental context where the firm is operating, measured as the growth competitive index that reflects the competitive level of the country, was shown to have an influence on the firms' innovative efforts.[EconLit Citations: M10, 013, 036].
Impact of perioperative prognostic nutritional index changes on the survival of patients with stage II/III colorectal cancer
Authors: Tatsuta Kyota , Sakata Mayu , Kojima Tadahiro , Akai Toshiya , Shimizu Mikihiro , Morita Yoshifumi , Kikuchi Hirotoshi , Hiramatsu Yoshihiro , Kurachi Kiyotaka , Takeuchi Hiroya 
Published: May 2024

AbstractAimTo assess the impact of perioperative prognostic nutritional index (PNI) changes on prognosis and recurrence after colorectal cancer surgery.MethodsA total of 475 patients who underwent curative resection for primary colorectal adenocarcinoma and were diagnosed with pathological stage (pStage) II/III were retrospectively reviewed. The patients were divided into two groups: the high group (preoperative PNI ≤ postoperative PNI, n = 290) and the low group (preoperative PNI > postoperative PNI, n = 185).ResultsThe low group exhibited significantly higher recurrence and mortality rates (all p < 0.001). Kaplan–Meier analysis showed worse overall and recurrence‐free survival in the low group (all p < 0.001). Perioperative PNI changes predicted prognosis and recurrence independent of preoperative nutritional conditions. Subgroup analyses showed better overall survival and recurrence‐free survival in the high group across various parameters, such as patient background, surgical outcomes, adjuvant chemotherapy, and pathological characteristics. Multivariate analysis revealed that the low group based on perioperative PNI changes (hazard ratio [HR]: 5.809, 95% confidence interval [CI]: 3.451–9.779, p < 0.001), pathological T stage (HR: 1.962, 95% CI: 1.184–3.253, p = 0.009), and pathological N stage (HR: 3.434, 95% CI: 1.964–6.004, p < 0.001) were identified as independent predictors of worse overall survival.ConclusionsPatients with pStage II/III colorectal cancer who demonstrate a lower postoperative PNI levels compared to preoperative had poorer overall survival and recurrence‐free survival. Perioperative PNI changes can serve as useful biomarkers for predicting survival and recurrence.
Roles of Ferric Peroxide Anion Intermediates (Fe3+O2−, Compound 0) in Cytochrome P450 19A1 Steroid Aromatization and a Cytochrome P450 2B4 Secosteroid Oxidation Model
Authors: Tateishi Yasuhiro , McCarty Kevin D. , Martin Martha V. , Yoshimoto Francis K. , Guengerich F. Peter 
Published: May 2024

AbstractCytochrome P450 (P450, CYP) 19A1 is the steroid aromatase, the enzyme responsible for the 3‐step conversion of androgens (androstenedione or testosterone) to estrogens. The final step is C−C bond scission (removing the 19‐oxo group as formic acid) that proceeds via a historically controversial reaction mechanism. The two competing mechanistic possibilities involve a ferric peroxide anion (Fe3+O2−, Compound 0) and a perferryl oxy species (FeO3+, Compound I). One approach to discern the role of each species in the reaction is with the use of oxygen‐18 labeling, i.e., from 18O2 and H218O of the reaction product formic acid. We applied this approach, using several technical improvements, to study the deformylation of 19‐oxo‐androstenedione by human P450 19A1 and of a model secosteroid, 3‐oxodecaline‐4‐ene‐10‐carboxaldehyde (ODEC), by rabbit P450 2B4. Both aldehyde substrates were sensitive to non‐enzymatic acid‐catalyzed deformylation, yielding 19‐norsteroids, and conditions were established to avoid issues with artifactual generation of formic acid. The Compound 0 reaction pathway predominated (i.e., Fe3+O2−) in both P450 19A1 oxidation of 19‐oxo‐androstenedione and P450 2B4 oxidation of ODEC. The P450 19A1 results contrast with our prior conclusions (J. Am. Chem. Soc. 2014, 136, 15016–16025), attributed to several technical modifications.
Waste‐derived low‐grade glycerol purification and recovery from biorefineries: an experimental investigation
Authors: Attarbachi Taha , Kingsley Martin , Spallina Vincenzo 
Published: May 2024

AbstractA combination of different physio‐chemical treatment steps was applied to purify industrially derived crude glycerol at laboratory scale. The full process included acid–base treatments, phase separation, and adsorption, and the glycerol purity and recovery were optimized by varying the pH during saponification and acidification, the solvent‐to‐glycerol ratio, and type of base used in the process to enhance both. The testing campaign resulted in a final purity of up to 87% wt starting from a very low‐quality ‘end‐of‐life’ waste glycerol sampled from different refineries. The net glycerol recovery at laboratory scale reached 42% of the initial glycerol in the feedstock and the maximum ash removal exceeded 90% given the low quality of the feedstock and high content of impurities and the attempt to achieve high glycerol recovery. The experiment showed that mild operations such as saponification with KOH (pH of 8), acidification with H3PO4 (pH of 6), an ideal 2‐propanol to glycerol volume ratio equal to 3 and potassium hydroxide as a base for the neutralisation step were the optimum conditions despite the differences between samples. The sequence of the processes proposed was therefore considered a viable option to treat any kind of crude glycerol to make it profitable for fuel and chemical applications.
Prevalence and biopsychosocial indicators of fatigue in cancer patients
Authors: Zeilinger Elisabeth L. , Zrnic‐Novakovic Irina , Oppenauer Claudia , Fellinger Matthäus , Knefel Matthias , Unseld Matthias , Wagner Theresa , Lubowitzki Simone , Bartsch Rupert , Zöchbauer‐Müller Sabine , Raderer Markus , Staber Philipp B. , Valent Peter , Gaiger Alexander 
Published: May 2024

AbstractIntroductionSymptoms of cancer‐related fatigue (CRF) can have a significant impact on patients' quality of life and treatment adherence. We aimed to investigate the relationship between CRF and multiple psychosocial and somatic indicators within a large mixed cancer sample.MethodsIn this cross‐sectional study, N = 1787 outpatients with cancer were assessed for CRF, pain, anxiety, and depression using validated screening instruments. We further obtained clinical parameters (Hb, CRP, creatinine, leukocytes, ASAT, and ALAT), sociodemographic data (age, gender, income, education level, marital status, parenthood, and living area), and lifestyle factors. Multivariate linear regression models were applied to estimate the impact of each indicator on CRF.ResultsOverall, 90.6% of patients experienced some CRF, with 14.8% experiencing severe CRF. No gender difference was found in the prevalence of CRF. Patients with higher levels of pain, depressive symptoms, and lower Hb levels had significantly higher levels of CRF (ps <0.001). Lower levels of CRF were observed in patients who had children (p = 0.03), had less education (p < 0.001), and were physically active for more than 2 h per week before their oncological diagnosis (p = 0.014). The latter was only a significant indicator in the male subsample.ConclusionThe present results demonstrate a high prevalence of CRF and highlight that not only somatic and psychosocial factors, but also lifestyle factors prior to diagnosis appear to be associated with the etiology and persistence of CRF. To effectively treat CRF, a biopsychosocial, personalized approach is recommended.
Community sport, Australian sport policy, and advocacy: The views of community sport club officials
Authors: Mountifield Charles 
Published: May 2024

AbstractIn Australia, the policy priorities and processes of government and national governing bodies of sport impact how community sport organizations operate. This study explored the views of community sport club (CSC) officials (n = 53) in the Illawarra region in New South Wales, where there is a disparity in impact compared with their better‐resourced urban counterparts concerning sustainability, policy, and advocacy matters. Participants were surveyed for their views about the typically top‐down policy processes, inter‐organizational relationships, and advocacy for community sport. CSC officials participated in an online survey to assess opinions on resource issues and policy processes. The findings demonstrated that community sport is challenging to sustain and that CSC officials have little influence on policy. The outcome points to an appetite for advocacy from CSC officials in policy creation. Further, the Advocacy Coalition Framework is proffered as a platform for evaluating the viability of advocacy within community sport.
PL‐ReliefTMplus Alleviates Atopic Dermatitis and Regulates Inflammatory Responses via Inhibiting NF‐κB Signaling Pathway
Authors: Zhang Xiaohan , Shen Zhiyuan , Zhu Wei , Lin Lin , Fan Yangyi , Cheng Xiaoyu , Yu Min , Yu Sanjian , Zhao Bing 
Published: May 2024

AbstractBackground: Atopic dermatitis (AD) has various detrimental effects on individuals with limited drug cure rates which necessitate the development of new treatment methods. PL‐ReliefTMplus (PLR) is composed of SupraOlive, Crocus Sativus extracts and Citrus reticulata extracts. The effect of PLR on AD remains to be explored. Methods: 2,4‐dinitrofluorobenzene‐induced AD model mice were involved and the histopathology of the skin lesions was observed along with the levels of inflammatory chemokines levels were measured. To further validate the molecular mechanism of PLR, RNA‐seq was performed in HaCaT cells. Western blotting and immunofluorescence were performed to investigate NF‐κB signaling pathways response in AD. Results: Due to PLR treatment, the thickening of the epidermis and dermis was inhibited and the number of eosinophils, mast cells, and CD4+ T cells in the skin lesion was decreased. In addition, the levels of inflammatory cytokines were decreased in dorsal skin tissues and LPS‐stimulated HaCat cells. Furthermore, KEGG pathway analysis suggested that most identified downstream biological functions were associated with inflammatory response. PLR inhibited NF‐κB signaling in AD mice and HaCaT cells. Conclusions: These results indicate that PLR is a potent therapeutic agent for attenuating symptoms of AD.
Oncostatin M suppresses bone morphogenetic protein‐4‐induced osteoprotegerin synthesis in MC3T3‐E1 osteoblast‐like cells: p70 S6 kinase attenuation
Authors: Hioki Tomoyuki , Tachi Junko , Matsushima‐Nishiwaki Rie , Iida Hiroki , Kozawa Osamu , Tokuda Haruhiko 
Published: May 2024

AbstractEvidence is accumulating that osteal macrophages, in addition to bone‐resorbing osteoclasts and bone‐forming osteoblasts, participate vitally in bone remodeling process. Oncostatin M (OSM), an inflammatory cytokine belonging to interleukin‐6 superfamily, is recognized as an essential factor secreted by osteal macrophages to orchestrate bone remodeling. Osteoprotegerin (OPG) produced by osteoblasts regulates osteoclastogenesis. We have reported that bone morphogenetic protein‐4 (BMP‐4) stimulates OPG synthesis in MC3T3‐E1 osteoblast‐like cells, and that SMAD1/5/8(9), p38 mitogen‐activated protein kinase (MAPK), and p70 S6 kinase are involved in the OPG synthesis. The present study aims to investigate the effect of OSM on the synthesis of OPG stimulated by BMP‐4 in osteoblasts. OSM suppressed the release and the mRNA expression of OPG upregulated by BMP‐4 in MC3T3‐E1 cells. Neither the BMP‐4‐induced phosphorylation of SMAD1/5/9 nor that of p38 MAPK was affected by OSM. On the other hand, the phosphorylation of p70 S6 kinase stimulated by BMP‐4 was considerably suppressed by OSM. These results strongly suggest that OSM suppresses the BMP‐4‐stimulated OPG synthesis via inhibition of the p70 S6 kinase‐mediated pathway in osteoblast‐like cells.
Sunflower Pollen‐Derived Microspheres Selectively Absorb DNA for microRNA Detection
Authors: Yang Yao , Mou Ziye , Liu Qian , Wang Bin , Luo Chenjing , Xu Yuhang , Huang Qiuhong , He Binfeng , Chang Kai , Wang Guansong , You Zaichun , Qian Hang 
Published: May 2024

AbstractHerein, we report the finding that a naturally sunflower pollen‐derived microspheres (HSECs) with hierarchical structures can selectively absorb polyC and polyA with high efficiency and affinity. HSECs exhibit the capability to selectively absorb polyC and polyA ssDNA under neutral and acidic conditions. It has been observed that the presence of metal cations, specifically Ca2+, enhances the absorption efficiency of HSECs. Mechanically, this absorption phenomenon can be attributed to both electrostatic interactions and cation‐π interactions. Such an appealing property enables the functionalization of HSECs for broad potential biomedical applications, such as microRNA detection.
Polymer‐Based Nanoparticles for Inner Ear Targeted Trans Differentiation Gene Therapy
Authors: Foster Thomas , Lim Patrick , Jones Melissa , Wagle Susbin Raj , Kovacevic Bozica , Ionescu Corina Mihaela , Wong Elaine Y. M , Mooranian Armin , Al‐Salami Hani 
Published: May 2024

AbstractHearing loss is a significant disability that often goes under recognised, largely due to poor identification, prevention, and treatment. Steps are being made to amend these pitfalls in the investigation of hearing loss, however, the development of a cure to reverse advanced forms remains distant. This review details some current advances in the treatment of hearing loss, with a particular focus on genetic‐based nanotechnology and how it may provide a useful avenue for further research. This review presents a broad background on the pathophysiology of hearing loss and some current interventions. We also highlight some potential genes that may be useful in the amelioration of hearing loss. Pathways of cellular differentiation from stem or supporting cell to functional hair cell are covered in detail, as this mechanism represents a key means of regenerating these cell types. Overall, we believe that polymer‐based nanotechnology coupled with novel excipients represents a useful area of further research in the treatment of hearing loss, although further studies in this area are required.
Theoretical Investigations of Hydrolysis Mechanisms of N(SiMe3)3
Authors: Zhou Ying , Wang Jian , Peng Xiaomeng , Zhang Wenhua 
Published: May 2024

AbstractTris(trimethylsilyl)amine (N(SiMe3)3) is one of the most important intermediate products in the indirect synthesis of ammonia (NH3) from nitrogen (N2), which could be hydrolyzed to NH3 under mild conditions. Herein, the hydrolysis mechanism of N(SiMe3)3 has been systematically investigated using density functional theory (DFT) with explicit combined implicit water models. Under neutral conditions, the active barrier of the hydrolysis of N(SiMe3)3 is 17.6 kcal mol−1 in water solvent. The attacking of proton to N center and OH group to the Si atom from water is decoupled for the stabilization of OH group by solvent water molecules, which lower the hydrolysis energy barriers. Furthermore, under acid conditions, N(SiMe3)3 is easily coordinated with proton to form [NH(SiMe3)3]+, and the energy barrier of the hydrolysis reaction could be reduced to 11.5 kcal mol−1 of the first stage, making it being promoted according to the chemical equilibrium. Thus, the results provide an explanation for the possible mechanism of the quantitative conversion of N(SiMe3)3 to NH3 under mild conditions. The decoupled hydrolysis mechanism may play important role in other hydrolysis processes.
Photochemical Vs Thermal Acid Catalysed Cyclization of Cannabigerol (CBG): An Unexpected Selectivity
Authors: Bini Arianna , Mella Mariella , Merli Daniele , Protti Stefano 
Published: May 2024

AbstractThe reactivity of Cannabigerol (CBG, 1) in organic solvents under photochemical and acid catalyzed conditions has been investigated in detail. The obtained results pointed out the presence of different reaction paths in the photochemical and the acid‐catalyzed conditions, with a remarkable selectivity toward the formation of a 2,2‐disubstituted‐chromane derivative in the first case.
Demystifying early childhood computational thinking: An umbrella review to upgrade the field
Authors: Yang Weipeng , Su Jiahong , Li Hui 
Published: May 2024

AbstractBy transforming abstract problems into tangible solutions, computational thinking (CT) emerges as a foundational competency. This umbrella review synthesizes the current landscape of CT in early childhood, pivotal for fostering 21st‐century skills across multiple domains. A systematic search across Scopus, ACM Digital Library, and Web of Science yielded 13 review studies for analysis, addressing the integration of CT in early childhood education. Employing a narrative synthesis approach, the review illuminated key findings and highlighted future research trajectories. Findings indicate the centrality of creating sequences and events in imparting CT in early childhood, recommending more sophisticated concepts like loops and conditionals for older children. Instructional designs unearthed include scaffolding with narratives, tangible objects, and physical embodiments, balancing structured tasks and open‐ended engagement. Three categories of computational kits were discerned: physical, virtual, and hybrid kits. The Bee‐Bot and various LEGO kits were prevalent among CT learning tools, with interfaces ranging from physical buttons to hybrid systems. Efficacy was noted in tangible activities like unplugged applications and robotics in enhancing concrete understanding and competencies in coding, CT, and spatial skills. Concluding remarks discuss research gaps, future prospects, and provide actionable insights for educators and policy makers, calling for the co‐creation of an ecosystem of CT integration across early childhood curricula.
Ethanol embolotherapy of mandibular arteriovenous malformation‐induced acute oral hemorrhage after tooth extraction
Authors: Shen Yuchen , Wang Deming , Su Lixin , Fan Xindong , Yang Xitao 
Published: May 2024

AbstractBackgroundMandibular arteriovenous malformation (AVM) is rare. Our work aims to introduce the ethanol embolization of a patient suffering from acute oral hemorrhage induced by mandibular AVM.MethodsA 35‐year‐old woman without coagulopathy underwent tooth extraction, and the acute oral bleeding occurred intraoperatively. Imaging examinations indicated the enhancement of vascular mass with bone destruction inside the mandible. Angiography finally confirmed the high blood flow nature and the diagnosis of AVM.ResultsDuring the interventional procedure, the coils were first applied into the dilated outflowing vein to slow down the blood flow rate of mandibular AVM. Absolute ethanol was injected in a multi‐bolus modality to destroy the nidus of AVM. Her mandibular lesion had been stable in the 12‐month re‐examined angiography, no further bleeding occurred during the period.ConclusionsEthanol embolotherapy was a less invasive, more precise, and quick‐action approach managing AVM of the jaw and related emergency medicine.
Heavy metals toxicity on epigenetic modifications in the pathogenesis of Alzheimer's disease (AD)
Authors: Venkatesan Dhivya , Muthukumar Sindduja , Iyer Mahalaxmi , Babu Harysh Winster Suresh , Gopalakrishnan Abilash Valsala , Yadav Mukesh Kumar , Vellingiri Balachandar 
Published: May 2024

AbstractAlzheimer's disease (AD) is a progressive decline in cognitive ability and behavior which eventually disrupts daily activities. AD has no cure and the progression rate varies unlikely. Among various causative factors, heavy metals are reported to be a significant hazard in AD pathogenesis. Metal‐induced neurodegeneration has been focused globally with thorough research to unravel the mechanistic insights in AD. Recently, heavy metals suggested to play an important role in epigenetic alterations which might provide evidential results on AD pathology. Epigenetic modifications are known to play towards novel therapeutic approaches in treating AD. Though many studies focus on epigenetics and heavy metal implications in AD, there is a lack of research on heavy metal influence on epigenetic toxicity in neurological disorders. The current review aims to elucidate the plausible role of cadmium (Cd), iron (Fe), arsenic (As), copper (Cu), and lithium (Li) metals on epigenetic factors and the increase in amyloid beta and tau phosphorylation in AD. Also, the review discusses the common methods of heavy metal detection to implicate in AD pathogenesis. Hence, from this review, we can extend the need for future research on identifying the mechanistic behavior of heavy metals on epigenetic toxicity and to develop diagnostic and therapeutic markers in AD.
Efficient electrochemical immunosensor for detection of bovine interferon gamma‐based gold nanoparticles/chitosan composite
Authors: Wang Yuru , Li Jiayin , Yang Juan , Yang Linan , Chen Qingwen , Long Yan , Cao Liuyang , Yang Zhanjun , Chen Hui , Li Juan 
Published: May 2024

AbstractInterferon gamma (IFN‐γ) released by T lymphocytes, plays an important role in immune regulation and is also an important biomarker for the early diagnosis of bovine tuberculosis. In this work, an electrochemical immunosensor based on gold nanoparticles (AuNPs)/chitosan composite was developed for highly sensitive determination of bovine IFN‐γ. AuNPs/chitosan composite shows high surface area and good hydrophilicity. The bovine IFN‐γ immunosensor was prepared by immobilizing IFN‐γ antibody on AuNPs/chitosan composite‐modified glassy carbon electrode. The immunosensors were characterized by scanning electron microscopy, electrochemical impedance spectroscopy, and cyclic voltammetry (CV). Using horseradish peroxidase (HRP)‐labeled IFN‐γ antibody as amplification probe, the concentration of bovine IFN‐γ can be monitored via the increasing current signal, which can be attributed to the specific immune binding between bovine IFN‐γ antigen and HRP‐labeled IFN‐γ antibody, as well as the efficient catalysis reaction between thionine and HRP with the presence of H2O2. The developed electrochemical immunosensor exhibited a wide linear range of 0.01 to 30 ng/mL, and low detection limit of 0.003 ng/mL with good specificity and stability. This study provides a simple and promising method for diagnosis of bovine tuberculosis, which can be expanded to determine other biomarkers.