bluuebunny/crossref_metadata_2025_split huggingface dataset:
L'intérêt clinique du concept d'efficacité personnelle
Authors: de Almeida Carapato Elodia , Petot Jean-Michel 
Published: October 2010

Résumé La notion de sentiment d’efficacité personnelle se ramène à une idée très simple mais très éclairante, issue de la réflexion sur la pratique des thérapies comportementales : la capacité d’une personne à entreprendre certaines actions dépend largement de sa croyance dans cette capacité. Cette théorie éclaire les premières contributions de Bandura : la notion d’apprentissage vicariant, et donc la technique psychothérapeutique du modeling , qui est interprétée, comme le sont finalement tous les procédés des thérapies cognitivo-comportementales, comme autant de moyens d’augmenter le sentiment d’efficacité du patient et donc son efficacité réelle. La croyance dans sa propre efficacité apparaît dès lors comme un phénomène fondamental dans l’ensemble des processus qui assurent l’adaptation, la santé et le bien-être psychiques. Cette théorie rend également compte des troubles psychopathologiques les plus courants -anxiété, dépressions, troubles du comportement alimentaire et addictions - en termes de défaillances spécifiques de la croyance dans sa propre efficacité.
Orientation des adultes et formation tout au long de la vie
Authors: Aubret Jacques , Demouge Nicole 
Published: October 2010

Résumé À partir d’un recueil d’entretiens biographiques réalisés sur un public d’adultes engagés dans un stage de formation dans une période de mobilité professionnelle, nous analysons les rapports que l’on peut établir entre l’orientation des adultes et les injonctions à la formation tout au long de la vie. Deux variables (genre et statut professionnel), particulièrement influentes sur la carrière professionnelle, sont prises en compte. Les résultats montrent que les récits manifestent, mais de manière différenciée dans les groupes constitués sur la base du croisement des variables, un certain réalisme des sujets en ce qui concerne l’expression de leurs aspirations : ouverture pour les uns, adaptation aux environnements du travail et de la famille pour d’autres, résignation pour d’autres encore. Ils valident l’idée que l’entrée en formation n’est qu’un moment dans un processus d’orientation et que les pratiques d’accompagnement des adultes, telles que le bilan de compétences, trouvent leur justification dans la nécessité de proposer aux étapes cruciales de leur parcours de vie des activités de réflexion sur soi, d’analyse de l’expérience, d’aide à l’évaluation, susceptibles de développer de nouvelles motivations à s’investir, lorsque les contraintes du travail et de l’environnement tendent à enfermer les personnes sur elles-mêmes.
GM-CSF Is an Essential Regulator of T Cell Activation Competence in Uterine Dendritic Cells during Early Pregnancy in Mice
Authors: Moldenhauer Lachlan M. , Keenihan Sarah N. , Hayball John D. , Robertson Sarah A. 
Published: October 2010

Abstract
Uterine dendritic cells (DCs) are critical for activating the T cell response mediating maternal immune tolerance of the semiallogeneicfetus. GM-CSF (CSF2), a known regulator of DCs, is synthesized by uterine epithelial cells during induction of tolerance in early pregnancy. To investigate the role of GM-CSF in regulating uterine DCs and macrophages, Csf2-null mutant and wild-type mice were evaluated at estrus, and in the periconceptual and peri-implantation periods. Immunohistochemistry showed no effect of GM-CSF deficiency on numbers of uterine CD11c+ cells and F4/80+ macrophages at estrus or on days 0.5 and 3.5 postcoitum, but MHC class II+ and class A scavenger receptor+ cells were fewer. Flow cytometry revealed reduced CD80 and CD86 expression by uterine CD11c+ cells and reduced MHC class II in both CD11c+ and F4/80+ cells from GM-CSF–deficient mice. CD80 and CD86 were induced in Csf2−/− uterine CD11c+ cells by culture with GM-CSF. Substantially reduced ability to activate both CD4+ and CD8+ T cells in vivo was evident after delivery of OVA Ag by mating with Act-mOVA males or transcervical administration of OVA peptides. This study shows that GM-CSF regulates the efficiency with which uterine DCs and macrophages activate T cells, and it is essential for optimal MHC class II- and class I-mediated indirect presentation of reproductive Ags. Insufficient GM-CSF may impair generation of T cell-mediated immune tolerance at the outset of pregnancy and may contribute to the altered DC profile and dysregulated T cell tolerance evident in infertility, miscarriage, and preeclampsia.
Ground States of Two-component Bose-Einstein Condensates with an Internal Atomic Josephson Junction
Authors: Bao Weizhu , Cai Yongyong 
Published: October 2010

AbstractIn this paper, we prove existence and uniqueness results for the ground states of the coupled Gross-Pitaevskii equations for describing two-component Bose-Einstein condensates with an internal atomic Josephson junction, and obtain the limiting behavior of the ground states with large parameters. Efficient and accurate numerical methods based on continuous normalized gradient flow and gradient flow with discrete normalization are presented, for computing the ground states numerically. A modified backward Euler finite difference scheme is proposed to discretize the gradient flows. Numerical results are reported, to demonstrate the efficiency and accuracy of the numerical methods and show the rich phenomena of the ground sates in the problem.
A Blueprint for Telerehabilitation Guidelines
Authors: Brennan David , Tindall Lyn , Theodoros Deborah , Brown Janet , Campbell Michael , Christiana Diana , Smith David , Cason Jana , Lee Alan 
Published: October 2010

Telerehabilitation refers to the delivery of rehabilitation services via information and communication technologies. Clinically, this term encompasses a range of rehabilitation and habilitation services that include assessment, monitoring, prevention, intervention, supervision, education, consultation, and counseling. Telerehabilitation has the capacity to provide service across the lifespan and across a continuum of care. Just as the services and providers of telerehabilitation are broad, so are the points of service, which may include health care settings, clinics, homes, schools, or community-based worksites. This document was developed collaboratively by members of the Telerehabilitation SIG of the American Telemedicine Association, with input and guidance from other practitioners in the field, strategic stakeholders, and ATA staff. Its purpose is to inform and assist practitioners in providing effective and safe services that are based on client needs, current empirical evidence, and available technologies. Telerehabilitation professionals, in conjunction with professional associations and other organizations are encouraged to use this document as a template for developing discipline-specific standards, guidelines, and practice requirements.
Heavy Smoking in Midlife and Long-term Risk of Alzheimer Disease and Vascular Dementia
Authors: Rusanen Minna , Kivipelto Miia , Quesenberry Charles P. , Zhou Jufen , Whitmer Rachel A. 
Published: October 2010

BackgroundSmoking is a risk factor for several life-threatening diseases, but its long-term association with dementia is controversial and somewhat understudied. Our objective was to investigate the long-term association of amount of smoking in middle age on the risk of dementia, Alzheimer disease (AD), and vascular dementia (VaD) several decades later in a large, diverse population.MethodsWe analyzed prospective data from a multiethnic population-based cohort of 21 123 members of a health care system who participated in a survey between 1978 and 1985. Diagnoses of dementia, AD, and VaD made in internal medicine, neurology, and neuropsychology were collected from January 1, 1994, to July 31, 2008. Multivariate Cox proportional hazards models were used to investigate the association between midlife smoking and risk of dementia, AD, and VaD.ResultsA total of 5367 people (25.4%) were diagnosed as having dementia (including 1136 cases of AD and 416 cases of VaD) during a mean follow-up period of 23 years. Results were adjusted for age, sex, education, race, marital status, hypertension, hyperlipidemia, body mass index, diabetes, heart disease, stroke, and alcohol use. Compared with nonsmokers, those smoking more than 2 packs a day had an elevated risk of dementia (adjusted hazard ratio [HR], 2.14; 95% CI, 1.65-2.78), AD (adjusted HR, 2.57; 95% CI, 1.63-4.03), and VaD (adjusted HR, 2.72; 95% CI, 1.20-6.18).ConclusionsIn this large cohort, heavy smoking in midlife was associated with a greater than 100% increase in risk of dementia, AD, and VaD more than 2 decades later. These results suggest that the brain is not immune to long-term consequences of heavy smoking.
Color Tunable Poly (N‐Isopropylacrylamide)‐co‐Acrylic Acid Microgel–Au Hybrid Assemblies
Authors: Sorrell Courtney D. , Carter Matthew C. D. , Serpe Michael J. 
Published: October 2010

AbstractA new class of materials that are capable of color tunability over 300 nm with a 15 °C temperature change is introduced. The materials are assembled from thermoresponsive poly (N‐isopropylacrylamide)‐co‐acrylic acid (pNIPAm‐co‐AAc) microgels, which are deposited on Au coated glass substrates. The films are also pH responsive; the temperature‐induced color change was suppressed at high pH and is consistent with the behavior of a solution of suspended microgels. The mechanism proposed to account for the observed optical properties suggests that they result from the two Au layers being separated from each other by the “monolithic” microgel film, much like a Fabry‐Pérot etalon or interferometer. It is the modulation of the distance between these two layers, facilitated by the microgel collapse transition at high temperature, that allows the color to be tuned. The sensitivity of the system presented here will be used for future sensing and biosensing applications, as well as for light filtering applications.
Divergent Preparation of Fluoroalkylated Sulfilimine and Sulfilimino Iminium Salts
Authors: Urban Céline , Macé Yohan , Cadoret Frédéric , Blazejewski Jean‐Claude , Magnier Emmanuel 
Published: October 2010

AbstractWe have successfully extended our previously described methodology for the preparation of trifluoromethyl N‐acyl sulfilimines to the case of bromodifluoro‐ and dichlorofluoromethyl derivatives. Attempts to convert such N‐acyl sulfilimines to free NH‐sulfilimines failed. However, a strategy based on the reaction of their direct ditriflyl ketal precursor with amines allows the isolation of either original sulfilimino iminium salts using secondary amines or of free NH‐sulfilimines using primary amines. The latter were further easily N‐functionalized with electron‐withdrawing groups giving structures close to those of efficient perfluoroalkylating agents. Preliminary experiments showed that these new sulfilimine‐based compounds have poor perfluoroalkylating abilities, demonstrating that the sulfilimine function is not sufficiently activating for that purpose, contrary to sulfur(VI) reagents.
Combination Catalysis in Enantioselective Trifluoromethylation
Authors: Zheng Yan , Ma Jun‐An 
Published: October 2010

AbstractThe application of combination catalysis in enantioselective trifluoromethylation reactions is illustrated. Four ground‐breaking studies have described the efficient catalytic enantioselective nucleophilic trifluoromethylation of ketones and azomethine imines in the presence of the combination of a Cinchona alkaloid‐derived ammonium salt and different nucleophilic initiators, whereas the highly enantioselective electrophilic and radical trifluoromethylation of aldehydes could be achieved via the combination of chiral organocatalysts and metal salts.
Targeting prevention programs for young and new healthcare workers: what is the association of age and job tenure with occupational injury in healthcare?
Authors: Siow Serena , Ngan Karen , Yu Shicheng , Guzman Jaime 
Published: October 2010

AbstractBackgroundPrevious evidence suggests young and new workers experience an increased risk of occupational injury. We sought to confirm this observation for healthcare workers.MethodsA retrospective cohort of 42,771 healthcare workers (88.2% women) was constructed from an active injury surveillance database. Over 2 years, incidence rates and crude and adjusted relative risks for occupational injury were compared between age groups and job tenures.ResultsThere were opposite trends in the two main types of injuries which cancelled each other: new workers and young workers had a decreased (not increased) risk of musculoskeletal sprain and strain injuries (adjusted RR [95% CI] for new hires was 0.60 [0.48, 0.73], and 0.85 [0.73, 0.98] for workers <25 years old); but an increased risk of cut and puncture injuries (1.25 [1.07, 1.45] for new hires, 1.28 [0.99, 1.67] for workers <25 years old).ConclusionsContrary to studies of other sectors, younger age and shorter tenure were not universal risk factors for occupational injuries in the female dominated healthcare sector. Young and new workers had increased risk of cuts and punctures, but a decreased risk of musculoskeletal injuries. Am. J. Ind. Med. 54:32–39, 2011. © 2010 Wiley‐Liss, Inc.
Germinal mosaicism in Noonan syndrome: A family with two affected siblings of normal parents
Authors: Elalaoui Siham Chafai , Kraoua Lilia , Liger Céline , Ratbi Ilham , Cavé Hélène , Sefiani Abdelaziz 
Published: October 2010

AbstractNoonan syndrome (NS; OMIM 163950) is an autosomal dominant disorder with variable clinical expression and genetic heterogeneity. Clinical manifestations include characteristic facial features, short stature, and cardiac anomalies. Mutations in protein‐tyrosine phosphatase, non‐receptor‐type 11 (PTPN11), encoding SHP‐2, account for about half of NS patients. We report on a Moroccan family with two children with NS and apparently unaffected parents. The molecular studies showed the heterozygous mutation c.922A>G of PTPN11 gene in the two affected sibs. Neither the parents, nor the oldest brother carries this mutation in hematologic cells. The mutation was also absent in buccal epithelial cells and fingernails of both parents. We believe this is the first report of germ cell mosaicism in NS and suggest an empirical risk for recurrence of that is less than 1%. © 2010 Wiley‐Liss, Inc.
HERV‐mediated genomic rearrangement of EYA1 in an individual with branchio‐oto‐renal syndrome
Authors: Sanchez‐Valle Amarilis , Wang Xueqing , Potocki Lorraine , Xia Zhilian , Kang Sung‐Hae L. , Carlin Mary E. , Michel Donnice , Williams Patricia , Cabrera‐Meza Gerardo , Brundage Ellen K. , Eifert Anna L. , Stankiewicz Pawel , Cheung Sau Wai , Lalani Seema R. 
Published: October 2010

AbstractBranchio‐oto‐renal syndrome is characterized by branchial defects, hearing loss, preauricular pits, and renal anomalies. Mutations in EYA1 are the most common cause of branchio‐oto‐renal and branchio‐otic syndromes. Large chromosomal aberrations of 8q13, including complex rearrangements occur in about 20% of these individuals. However, submicroscopic deletions and the molecular characterization of genomic rearrangements involving the EYA1 gene have rarely been reported. Using the array‐comparative genomic hybridization, we identified non‐recurrent genomic deletions including the EYA1 gene in three patients with branchio‐oto‐renal syndrome, short stature, and developmental delay. One of these deletions was mediated by two human endogenous retroviral sequence blocks, analogous to the AZFa microdeletion on Yq11, responsible for male infertility. This report describes the expanded phenotype of individuals, resulting from contiguous gene deletion involving the EYA1 gene and provides a molecular description of the genomic rearrangements involving this gene in branchio‐oto‐renal syndrome. © 2010 Wiley‐Liss, Inc.
Southeast Asian origins of five Hill Tribe populations and correlation of genetic to linguistic relationships inferred with genome‐wide SNP data
Authors: Listman J.B. , Malison R.T. , Sanichwankul K. , Ittiwut C. , Mutirangura A. , Gelernter J. 
Published: October 2010

AbstractIn Thailand, the term Hill Tribe is used to describe populations whose members traditionally practice slash and burn agriculture and reside in the mountains. These tribes are thought to have migrated throughout Asia for up to 5,000 years, including migrations through Southern China and/or Southeast Asia. There have been continuous migrations southward from China into Thailand for approximately the past thousand years and the present geographic range of any given tribe straddles multiple political borders. As none of these populations have autochthonous scripts, written histories have until recently, been externally produced. Northern Asian, Tibetan, and Siberian origins of Hill Tribes have been proposed. All purport endogamy and have nonmutually intelligible languages. To test hypotheses regarding the geographic origins of these populations, relatedness and migrations among them and neighboring populations, and whether their genetic relationships correspond with their linguistic relationships, we analyzed 2,445 genome‐wide SNP markers in 118 individuals from five Thai Hill Tribe populations (Akha, Hmong, Karen, Lahu, and Lisu), 90 individuals from majority Thai populations, and 826 individuals from Asian and Oceanean HGDP and HapMap populations using a Bayesian clustering method. Considering these results within the context of results ofrecent large‐scale studies of Asian geographic genetic variation allows us to infer a shared Southeast Asian origin of these five Hill Tribe populations as well ancestry components that distinguish among them seen in successive levels of clustering. In addition, the inferred level of shared ancestry among the Hill Tribes corresponds well to relationships among their languages. Am J Phys Anthropol, 2011. © 2010 Wiley‐Liss, Inc.
Behavioral thermoregulation in a gregarious lemur, Eulemur collaris: Effects of climatic and dietary‐related factors
Authors: Donati Giuseppe , Ricci Eva , Baldi Nicoletta , Morelli Valentina , Borgognini‐Tarli Silvana M. 
Published: October 2010

AbstractPrimates deal with fluctuations of the thermal environment by both physiological and behavioral mechanisms of thermoregulation. In this article we focus on nonhibernating lemurs, which are hypometabolic and have to cope with a seasonal environment. Behavioral thermoregulation has received little attention compared with specific physiological adaptations to seasonality, i.e., hibernation and torpor, which characterize a number of lemurs. We investigated the role of seasonality and dietary‐related factors in determining frequencies of resting, social and postural thermoregulation, and microhabitat selection in collared lemurs, Eulemur collaris. We observed two groups of collared lemurs over a 14‐month period in the littoral forest of Sainte Luce, Southern Madagascar. Frequencies of total resting and time spent in huddling, prone, and curled postures were collected via 5‐min instantaneous sampling. Microhabitat selection was evaluated as the proportion of time spent in the upper canopy as compared with other layers. Climatic variables were recorded by automatic data loggers, while dietary variables were derived from phenological data and nutritional analyses of the ingested food items. We weighted the combined effects of climatic and dietary variables on the different types of behavioral thermoregulation by means of canonical correlation analysis. The model with the strongest canonical correlation included a first root representing mainly feeding time, day length, and ambient temperature and a second root representing diet quality and height of feeding trees. The output indicated that collared lemurs adapt to thermal and dietary‐related metabolic stress by adjusting resting time, social, and postural thermoregulation. Am J Phys Anthropol, 2011. © 2010 Wiley‐Liss, Inc.
U‐Shaped Conformation of Alkyl Chains Bound to a Synthetic Receptor Cucurbit[8]uril
Authors: Ko Young Ho , Kim Youngkook , Kim Hyunuk , Kim Kimoon 
Published: October 2010

AbstractThe behavior of a series of alkanes bound to the molecular host cucurbit[8]uril (CB[8]) has been systematically studied by 2D 1H NMR spectroscopy and isothermal titration calorimetry (ITC). CB[8] and alkyltrimethylammonium (CmTA+, (CH3)3N+CmH2m+1, m=6–16) form 1:1 host–guest complexes with a high binding constant (K≈106 m−1). The shortest hexyl chain of C6TA+ can be fully encapsulated in an extended conformation inside the CB[8] cavity, which is driven by both enthalpy and entropy. However, for the longer aliphatic chains, C8–C16, the long alkyl tails take a U‐shaped conformation inside the cavity, and their complexation is dominantly or almost exclusively enthalpy‐driven, owing to the increased van der Waals contact between the folded aliphatic chain and the inner wall of the host cavity. As the chain length increases from C8 to C16, the ammonium head group of the guests moves away from the portal of CB[8] while the long aliphatic tails maintain the U‐shaped conformation inside the cavity. The complexation of CmTA+ with CB[8] follows the enthalpy–entropy compensation rule commonly observed in molecular recognition systems. For example, among the guest molecules, C12TA+ shows the highest enthalpic gain (most favorable), owing to the large van der Waals contact between the guest and the host cavity, and at the same time the most unfavorable entropic contribution, owing to the severe conformational restriction of the U‐shaped alkyl chain inside the host. The enthalpy–entropy compensation plot for the complexation suggests large conformational changes of the long alkyl chains and extensive dehydration associated with the inclusion complex formation.
HIV protease inhibitors: garlic supplements and first‐pass intestinal metabolism impact on the therapeutic efficacy
Authors: Berginc Katja , Trdan Tina , Trontelj Jurij , Kristl Albin 
Published: October 2010

AbstractBackground/Aims. The aim of this study was to elucidate the impact of first‐pass intestinal metabolism to therapeutic efficacy of antiretrovirals and to ascertain interaction mechanisms between garlic supplements (aged garlic extract) and HIV‐protease inhibitors.Methods. In vitro permeability through rat jejunum, Caco‐2 cell monolayers was determined and CYP3A4 metabolism studies were performed.Results. Saquinavir and darunavir efflux from enterocytes into gastrointestinal lumen significantly increased in the presence of aged garlic extract, whereas their CYP3A4 metabolism was inhibited. In the case of saquinavir a significant increase of its efflux was observed also in the presence of lower ritonavir doses. Because both drugs bound to different binding sites on P‐glycoprotein and/or multidrug resistance associated protein 2 than garlic phytochemicals or ritonavir, lower amounts of antiretrovirals were absorbed.Conclusions. The fractions of tested anti‐HIV drugs absorbed could decrease significantly during self‐medication with garlic supplements or ritonavir dose adjustments. Due to distinct saquinavir and darunavir preferences for binding sites on efflux transporters, the presence of other compounds (garlic phytochemicals, ritonavir), capable of influencing intestinal transporter–enzyme interplay, might lead to pharmacokinetic interactions observed in clinical studies and case reports with anti‐HIV drugs. Copyright © 2010 John Wiley & Sons, Ltd.