bluuebunny/crossref_metadata_2025_split huggingface dataset:
Regulatory Diversity as Key to the “Myth” of Drug Patenting in Sub-Saharan Africa
Authors: Adusei Poku 
Published: March 2010

AbstractThis article critiques the subject of patent protection of drugs in the light of the threat posed by HIV/AIDS in sub-Saharan Africa. It contends that the basis for sustaining the prevailing international patent system in developing countries is a “myth”: one of deception. This “myth” is validated by highlighting the dysfunctions associated with the prevailing international patent system. The article proposes the adoption of diverse patent systems that would suit the cultural and human development needs of countries in sub-Saharan Africa. Such diversity implies a drug patent model that meets human needs and shows respect for communal interests, a model that permits differences and is amenable to change in the light of socio-economic needs, a model that confronts “unfreedoms” which constrain human development, and a model that ensures respect and protection for the fundamental right to health care.
Traditional Courts and the Struggle against State Impunity for Civil Wartime Offences in Mozambique
Authors: Igreja Victor 
Published: March 2010

AbstractIn the Mozambican context of the state amnesty for civil war crimes, war survivors have used their local ethics of reciprocity to create justice. This article analyses how survivors have attempted to persuade judges in traditional courts to adjudicate in serious wartime disputes. These judges, who have no official mandate to redress wartime offences, tried to preserve the conflicting interests of the litigants and the state. This positioning, coupled with the fact that the local ethics of reciprocity are embedded in uneven power and gender relations, resulted in some cases being adjudicated and others not, and in some disputes receiving no gender justice. Nevertheless, some of the interventions indicate that national and international institutions of justice are not the only ones engaged in the struggle against impunity for wartime crimes. In Mozambique, specific attention must be paid to the study of traditional justice mechanisms as fonts of redress for wartime crimes and for the long-term contribution they can make.
Economic potential of individual variation in milk yield response to concentrate intake of dairy cows
Authors: ANDRÉ G. , BERENTSEN P. B. M. , VAN DUINKERKEN G. , ENGEL B. , LANSINK A. G. J. M. OUDE 
Published: March 2010

SUMMARYThe objectives of the current study were to quantify the individual variation in daily milk yield response to concentrate intake during early lactation and to assess the economic prospects of exploiting the individual variation in milk yield response to concentrate intake. In an observational study, data from 299 cows on four farms in the first 3 weeks of the lactation were collected. Individual response in daily milk yield to concentrate intake was analysed by a random coefficient model. Marked variation in individual milk yield response to concentrate intake was found on all four farms. An economic simulation was carried out, based on the estimated parameter values in the observational study. Individual optimization of concentrate supply is compared with conventional strategies for concentrate supply based on averaged population response parameters. Applying individual economic optimal settings for concentrate supply during early lactation, potential economic gain ranges from €0·20 to €2·03/cow/day.
Accuracy and stiffness analysis of a 3-RRP spherical parallel manipulator
Authors: Enferadi Javad , Tootoonchi Alireza Akbarzadeh 
Published: March 2010

SUMMARYIn this paper, accuracy and stiffness analysis of a 3-RRP spherical parallel manipulator (SPM) (Enferadi and Tootoonchi, A novel spherical parallel manipulator: Forward position problem, singularity analysis and isotropy design, Robotica, vol. 27, 2009, pp. 663–676) with symmetrical geometry is investigated. At first, the 3-RRP SPM is introduced and its inverse kinematics analysis is performed. Isotropic design, because of its design superiority, is selected and workspace of the manipulator is obtained. The kinematics conditioning index (KCI) is evaluated on the workspace. Global conditioning index (GCI) of the manipulator is calculated and compared with another SPM. Unlike traditional stiffness analysis, the moving platform is assumed to be flexible. A continuous method is used for obtaining mathematical model of the manipulator stiffness matrix. This method is based on strain energy and Castigliano's theorem. The mathematical model is verified by finite element model. Finally, using mathematical model, kinematics stiffness index (KSI), and global stiffness index (GSI) are evaluated.
Of the Family Tree: Congruence on Filial Obligation between Older Parents and Adult Children in Japanese Canadian Families
Authors: Kobayashi Karen M. , Funk Laura 
Published: March 2010

RÉSUMÉS’inspirant de l’hypothèse d’enjeu intergénérationelle (Bengtson and Kuypers, 1971), cet’article étudie la congruence et l’in-congruence entre les générations sur l’obligation filiale, et les implications pour l’assistance sociale, entre les parents anciens nisei (la seconde génération) et les enfants adultes de sansei (la troisième génération) dans les familles canadiennes japonaises. À l’aide des données des entretiens semi-structurés avec 100 dyads parent-enfant en la Colombie Britannique, la congruence sur des réponses fermées aux déclarations de valeur (la congruence de degré) et la congruence de contenu des réponses ouvertes sont examinés. Les conclusions montrent que la majorité des dyads parent-enfant indique congruence globale (degré et contenu) en ligne directe d’obligation, surtout lorsqu’un parent est féminin, veuf, ou dont l’état de santé est mauvaise ou passable. Nous concluons que, malgré des expériences sensiblement différentes dans le cours de la vie et des processus d’acculturation différents, les deux générations continuent de considérer l’obligation filiale comme importante. Ces conclusions sont discutées quant aux implications pour les échanges de soutien social, étant donné une évaluation continue de l’obligation filiale en Asie post-immigrant (né en Amérique du Nord) et familles immigrantes.
Relations between Immigrant Care Workers and Older Persons in Home and Long-Term Care
Authors: Bourgeault Ivy Lynn , Atanackovic Jelena , Rashid Ahmed , Parpia Rishma 
Published: March 2010

RÉSUMÉLes aidants immigrés jouent un rôle de plus en plus important dans les soins de domicile et les soins de longue durée au Canada, mais l’ampleur totale de leurs relations avec les personnes âgées dans ces cadres est relativement inconnue. Cet article examine le rôle des aidants immigrés dans les deux secteurs de domicile et de soins de longue durée, mettant l’accent sur les relations avec les anciens et les implications pour la qualité des soins. Les données proviennent des entrevues avec les travailleurs, les employeurs et les clients anciens menées dans divers services d’accueil et de soins de longue durée pour personnes âgées dans trois provinces canadiennes: l’Ontario, la Colombie-Britannique et le Québec. Les facteurs qui découlent des origines ethniques ou raciales des aidants immigrés, barrières linguistiques et facteurs contextuels tels que la pénurie de personnel en soins de différents paramètres pour les personnes âgées compliquent la relation entre les aidants immigrés et leurs clients. Dans certains cas, ces facteurs diminuent la qualité des soins. Nous indiquons quelques politiques alternatives que nos conclusions suggèrent devraient être considérées.
Fibrillin-1 gene intron 56 polymorphism in Turkish children with mitral valve prolapse
Authors: Ozdemir Osman , Olgunturk Rana , Karaer Kadri , Ergun Mehmet Ali , Tunaoglu Fatma Sedef , Kula Serdar , Percin Ferda Emriye 
Published: March 2010

AbstractObjectiveMitral valvar prolapse is the most common anomaly of the mitral valve apparatus throughout childhood. Fibrillin is one of the structural components of the elastin-associated microfibrils found in the mitral valve. A case-controlled study has performed to investigate the relationship between fibrillin 1 gene intron 56 polymorphism and risk of mitral valvar prolapse in Turkish children.Patients and methodsA total of 77 patients with mitral valvar prolapse diagnosed by clinical evaluation and echocardiography and 89 normal children of same age and sex were studied. The fibrillin-1 gene intron 56 polymorphism was identified by the polymerase chain reaction-based restriction analysis.ResultsThere was a significant difference in the distribution of fibrillin-1 gene intron 56 genotypes (p = 0.0001) and allelic frequency (p = 0.0001) between the cases and the controls.ConclusionsPatients with mitral valvar prolapse have higher frequencies of fibrillin-1 gene intron 56 GC genotypes. Healthy children have higher frequencies of fibrillin-1 gene intron 56 CC genotypes. We speculate that the higher frequency of fibrillin-1 gene intron 56 G-allele increases the risk of mitral valvar prolapse.
Direct non-medical and indirect costs for families with children with congenital cardiac defects in Germany: a survey from a university centre
Authors: Gerber Andreas U. , Hompanera Torre Agnieszka , Büscher Guido , Stock Stephanie A.K. , Graf Christine , Schickendantz Sabine , Brockmeier Konrad , Lüngen Markus 
Published: March 2010

AbstractIntroductionParents of children with congenital cardiac disease suffer from psychological stress and financial burdens. These costs have not yet been quantified.Materials and methodsIn cooperation with paediatricians, social workers, and parents, a questionnaire was devised to calculate direct non-medical and indirect costs. Direct non-medical costs include all costs not directly related to medical services such as transportation. Indirect costs include lost productivity measured in lost income from wages. Parents were retrospectively queried on costs and refunds incurred during the child’s first and sixth year of life. The questionnaire was sent out to 198 families with children born between 1980 and 2000. Costs were adjusted for inflation to the year 2006. Children were stratified into five groups according to the severity of their current health status.ResultsFifty-four families responded and could be included into the analysis (27.7%). Depending on severity, total direct non-medical and indirect costs in the first year of life ranged between an average of €1654 in children with no or mild (remaining) cardiac defects and an average €2881 in children with clinically significant (residual/remaining) findings. Mean expenses in the sixth year of life were as low as €562 (no or mild (remaining) cardiac defects) and as high as €5213 (potentially life-threatening findings). At both points in time, the highest costs were lost income and transportation; and day care/ babysitting for siblings was third.DiscussionFamilies of children with congenital cardiac disease and major sequelae face direct non-medical and indirect costs adding up to €3000 per year on average. We should consider compensating families from low socioeconomic backgrounds to minimise under-use of non-medical services of assistance for their children.
Chaotic atrial tachycardia-related ventricular fibrillation in a 2-month-old baby with Wolff-Pakinson-White syndrome
Authors: Ko Jae K. , Kim Young H. , Park In S. 
Published: March 2010

AbstractA 2-month-old baby was resuscitated from ventricular fibrillation attributed to a concurrent chaotic atrial tachycardia with Wolff-Parkinson-White syndrome. He underwent successful radiofrequency catheter ablation of an accessory pathway. Throughout the 4-year follow-up after the procedure, the boy remained free of any drugs, was in sinus rhythm without ventricular pre-excitation and his growth and development were normal.
Pregnancy-associated cardiomyopathy occurring in a young patient with nephropathic cystinosis
Authors: Ramappa Arun J. , Pyatt Jason R. 
Published: March 2010

AbstractCystinosis is a rare autosomal recessive metabolic disorder characterised by an intracellular accumulation of cystine leading to severe organ dysfunction. It affects renal function, has extra-renal complications but has rarely been associated with cardiac disease. Renal transplantation and cysteamine have dramatically improved the prognosis in the nephropathic form. We present the case of a young adult Caucasian female diagnosed with nephropathic cystinosis and receiving haemodialysis who subsequently developed dilated cardiomyopathy. She presented with acute cardiac failure occurring early after stillbirth following an unplanned pregnancy when her cysteamine had been stopped. Transthoracic echocardiography showed typical features of dilated cardiomyopathy which was absent on pre-pregnancy scans. Investigations failed to identify an underlying cause for her cardiomyopathy. She responded to conventional treatment and currently has had full recovery of her cardiac function confirmed on follow-up echocardiography. As cardiomyopathy rarely co-exists with cystinosis, we believe that this case represents pregnancy-associated cardiomyopathy rather than direct involvement by her cystinosis, particularly as a minority of pregnant patients with associated cardiomyopathy develop heart failure early before the conventional period for peripartum cardiomyopathy. Patient characteristics and maternal outcomes are similar, albeit with higher risk of premature delivery suggesting the same underlying pathological process.
Dating the cyanobacterial ancestor of the chloroplast
Authors: Falcón Luisa I , Magallón Susana , Castillo Amanda 
Published: March 2010

Abstract
Cyanobacteria have had a pivotal role in the history of life on Earth being the first organisms to perform oxygenic photosynthesis, which changed the atmospheric chemistry and allowed the evolution of aerobic Eukarya. Chloroplasts are the cellular organelles of photoautotrophic eukaryotes in which most portions of photosynthesis occur. Although the initial suggestion that cyanobacteria are the ancestors of chloroplasts was greeted with skepticism, the idea is now widely accepted. Here we attempt to resolve and date the cyanobacterial ancestry of the chloroplast using phylogenetic analysis and molecular clocks. We found that chloroplasts form a monophyletic lineage, are most closely related to subsection-I, N2-fixing unicellular cyanobacteria (Order Chroococcales), and heterocyst-forming Order Nostocales cyanobacteria are their sister group. Nostocales and Chroococcales appeared during the Paleoproterozoic and chloroplasts appeared in the mid-Proterozoic. The capability of N2 fixation in cyanobacteria may have appeared only once during the late Archaean and early Proterozoic eons. Furthermore, we found that oxygen-evolving cyanobacteria could have appeared in the Archaean. Our results suggest that a free-living cyanobacterium with the capacity to store starch through oxygenic CO2 fixation, and to fix atmospheric N2, would be a very important intracellular acquisition, which, as can be recounted today from several lines of evidence, would have become the chloroplast by endosymbiosis.
Analysis of the interactions between the C-terminal cytoplasmic domains of KCNQ1 and KCNE1 channel subunits
Authors: Zheng Renjian , Thompson Keith , Obeng-Gyimah Edmond , Alessi Dana , Chen Jerri , Cheng Huiyong , McDonald Thomas V. 
Published: March 2010

Ion channel subunits encoded by KCNQ1 and KCNE1 produce the slowly activating K+ current (IKs) that plays a central role in myocardial repolarization. The KCNQ1 α-subunit and the KCNE1 β-subunit assemble with their membrane-spanning segments interacting, resulting in transformation of channel activation kinetics. We recently reported a functional interaction involving C-terminal portions of the two subunits with ensuing regulation of channel deactivation. In the present study, we provide evidence characterizing a physical interaction between the KCNQ1-CT (KCNE1 C-terminus) and the KCNE1-CT (KCNE1 C-terminus). When expressed in cultured cells, the KCNE1-CT co-localized with KCNQ1, co-immunoprecipitated with KCNQ1 and perturbed deactivation kinetics of the KCNQ1 currents. Purified KCNQ1-CT and KCNE1-CT physically interacted in pull-down experiments, indicating a direct association. Deletion analysis of KCNQ1-CT indicated that the KCNE1-CT binds to a KCNQ1 region just after the last transmembrane segment, but N-terminal to the tetramerization domain. SPR (surface plasmon resonance) corroborated the pull-down results, showing that the most proximal region (KCNQ1 amino acids 349–438) contributed most to the bimolecular interaction with a dissociation constant of ~4 μM. LQT (long QT) mutants of the KCNE1-CT, D76N and W87F, retained binding to the KCNQ1-CT with comparable affinity, indicating that these disease-causing mutations do not alter channel behaviour by disruption of the association. Several LQT mutations involving the KCNQ1-CT, however, showed various effects on KCNQ1/KCNE1 association. Our results indicate that the KCNQ1-CT and the KCNE1-CT comprise an independent interaction domain that may play a role in IKs channel regulation that is potentially affected in some LQTS (LQT syndrome) mutations.
Signal peptide peptidase (SPP) assembles with substrates and misfolded membrane proteins into distinct oligomeric complexes
Authors: Schrul Bianca , Kapp Katja , Sinning Irmgard , Dobberstein Bernhard 
Published: March 2010

SPP (signal peptide peptidase) is an aspartyl intramembrane cleaving protease, which processes a subset of signal peptides, and is linked to the quality control of ER (endoplasmic reticulum) membrane proteins. We analysed SPP interactions with signal peptides and other membrane proteins by co-immunoprecipitation assays. We found that SPP interacts specifically and tightly with a large range of newly synthesized membrane proteins, including signal peptides, preproteins and misfolded membrane proteins, but not with all co-expressed type II membrane proteins. Signal peptides are trapped by the catalytically inactive SPP mutant SPPD/A. Preproteins and misfolded membrane proteins interact with both SPP and the SPPD/A mutant, and are not substrates for SPP-mediated intramembrane proteolysis. Proteins interacting with SPP are found in distinct complexes of different sizes. A signal peptide is mainly trapped in a 200 kDa SPP complex, whereas a preprotein is predominantly found in a 600 kDa SPP complex. A misfolded membrane protein is detected in 200, 400 and 600 kDa SPP complexes. We conclude that SPP not only processes signal peptides, but also collects preproteins and misfolded membrane proteins that are destined for disposal.
Imaging and manipulation of the competing electronic phases near the Mott metal-insulator transition
Authors: Kim Tae-Hwan , Angst M. , Hu B. , Jin R. , Zhang X.-G. , Wendelken J. F. , Plummer E. W. , Li An-Ping 
Published: March 2010

The complex interplay between the electron and lattice degrees of freedom produces multiple nearly degenerate electronic states in correlated electron materials. The competition between these degenerate electronic states largely determines the functionalities of the system, but the invoked mechanism remains in debate. By imaging phase domains with electron microscopy and interrogating individual domains in situ via electron transport spectroscopy in double-layered Sr
3
(Ru

1-
x

Mn

x

)
2
O
7
(
x
= 0 and 0.2), we show in real-space that the microscopic phase competition and the Mott-type metal-insulator transition are extremely sensitive to applied mechanical stress. The revealed dynamic phase evolution with applied stress provides the first direct evidence for the important role of strain effect in both phase separation and Mott metal-insulator transition due to strong electron-lattice coupling in correlated systems.
Developing reliable, repeatable, and accessible methods to provide high-resolution estimates of fishing-effort distributions from vessel monitoring system (VMS) data
Authors: Lee Janette , South Andy B. , Jennings Simon 
Published: March 2010

Abstract
Lee, J., South, A. B., and Jennings, S. 2010. Developing reliable, repeatable, and accessible methods to provide high-resolution estimates of fishing-effort distributions from vessel monitoring system (VMS) data. – ICES Journal of Marine Science, 67: 1260–1271. Vessel monitoring systems (VMS) are used primarily for fisheries enforcement purposes, but also provide information on the spatial and temporal distribution of fishing activity for use in fisheries and environmental assessment and management. A reliable, repeatable, and accessible method using readily available software for estimating fishing effort from unprocessed VMS data is developed, tested, and applied. Caveats associated with the method are identified, and the biases introduced by our assumptions are quantified. Application of the method provides a high-resolution description of gear-specific fishing activity by UK vessels. An index is developed to describe variation in the spatial pattern of fishing effort generated by different gears. The proposed method for VMS analysis involves removing duplicate VMS records and records close to ports, calculating the time interval between successive records to identify periods of activity, linking each record to a vessel and gear type, differentiating fishing and non-fishing activity, and summing fishing records in time and space to estimate fishing effort. The approach is a step towards the development of standardized methods to facilitate wider exchange and use of European VMS data. A clear audit trail for the methods of VMS analysis already used to inform management needs to be documented.