bluuebunny/crossref_metadata_2025_split huggingface dataset:
A reliable non‐volatile in‐memory computing associative memory based on spintronic neurons and synapses
Authors: Rezaei Mahan , Amirany Abdolah , Moaiyeri Mohammad Hossein , Jafari Kian 
Published: April 2024

AbstractThis article introduces an innovative non‐volatile associative memory (AM) that leverages spintronic synapses, employing magnetic tunnel junctions (MTJ) in conjunction with neurons constructed using carbon nanotube field‐effect transistors (CNTFETs). Our proposed design represents a significant advancement in area optimization and outperforms prior designs. We adopt MTJ‐based spintronic devices due to their remarkable attributes, including dependable reconfigurability and nonvolatility. Simultaneously, CNTFETs effectively address the longstanding limitations traditionally associated with MOSFETs. In this work, our proposed design undergoes rigorous simulations that account for process variations. The results demonstrate that our AM system closely approximates its ideal mathematical model, even with significant process variations. Furthermore, we investigate the impact of Tunnel Magnetoresistance (TMR) on the performance of our proposed AM system. Our investigations reveal that, even with a TMR as low as 100%, our design matches and often surpasses the performance of its counterparts operating with a TMR of 300%. This achievement holds profound significance from a fabrication standpoint, as fabricating MTJs with high TMR values can be intricate and costly. Overall, our novel AM system represents a significant breakthrough in emerging technologies, harnessing the unique strengths of spintronic synapses and advanced carbon nanotube transistors while robustly addressing challenges in performance and variability.
Effects of axial compression ratio on seismic behavior of shallow‐buried rectangular stations: Hybrid simulation and quasi‐static test
Authors: Cai Xuesong , Yang Chengyu , Liu Zhiqian , Jiang Liming , Yuan Yong 
Published: April 2024

AbstractIn the absence of experimental investigations on column members of underground structures, full‐scale column specimens were tested to explore the seismic behavior of shallow‐buried subway stations at various depths. The axial compression ratios of internal column specimens were set as 0.16, 0.33, and 0.40. Both hybrid simulations and quasi‐static tests were performed on the station columns. The hybrid simulations illustrated the drift demands of internal columns, while the load‐carrying capacity and deformation capacity were obtained from the quasi‐static tests. Hybrid simulations at low, moderate, and high‐intensity levels were conducted to study the seismic responses of shallow‐buried rectangular stations. The hybrid simulations suggest that the most severe damage occurred in the station when the axial compression ratio of the tested column reached 0.40. Central columns suffered severe stiffness deterioration under high‐level earthquake excitation, especially in stations at greater depths. Meanwhile, the quasi‐static test results indicate that the ultimate load of the central columns increases with increasing axial compression, but this leads to a significant decrease in the ductility of columns. Besides, the sectional analysis results show that the central columns are prone to tension‐controlled failure, and the safety margin for flexural response deteriorates with an increasing axial compression ratio. The test results indicate that shallow‐buried rectangular stations are susceptible to flexure‐controlled structural failure when their central columns possess a relatively low axial compression ratio and a high shear span‐to‐depth ratio. The failure mechanism of station columns is revealed by both the hybrid simulations and quasi‐static tests, and the findings from the full‐scale tests are beneficial for the practical design of shallow‐buried rectangular stations.
Comparing Sensitivity of Different Bee Species to Pesticides: A TKTD modeling approach
Authors: Baas Jan , Goussen Benoit , Taenzler Verena , Roeben Vanessa , Miles Mark , Preuss Thomas G. , Berg Sanne , Roessink Ivo 
Published: April 2024

Abstract
Risk assessment for bees is mainly based on data for honey bees; however, risk assessment is intended to protect all bee species. This raises the question of whether data for honey bees are a good proxy for other bee species. This issue is not new and has resulted in several publications in which the sensitivity of bee species is compared based on the values of the 48-h median lethal dose (LD50) from acute test results. When this approach is used, observed differences in sensitivity may result both from differences in kinetics and from inherent differences in species sensitivity. In addition, the physiology of the bee, like its overall size, the size of the honey stomach (for acute oral tests), and the physical appearance (for acute contact tests) also influences the sensitivity of the bee. The recently introduced Toxicokinetic–Toxicodynamic (TKTD) model that was developed for the interpretation of honey bee tests (Bee General Uniform Threshold Model for Survival [BeeGUTS]) could integrate the results of acute oral tests, acute contact tests, and chronic tests within one consistent framework. We show that the BeeGUTS model can be calibrated and validated for other bee species and also that the honey bee is among the more sensitive bee species. In addition, we found that differences in sensitivity between species are smaller than previously published comparisons based on 48-h LD50 values. The time-dependency of the LD50 and the specifics of the bee physiology are the main causes of the wider variation found in the published literature. Environ Toxicol Chem 2024;43:1431–1441. © 2024 The Authors. Environmental Toxicology and Chemistry published by Wiley Periodicals LLC on behalf of SETAC.
Experimental Ecotoxicology Procedures Interfere with Honey Bee Life History
Authors: Desclos le Peley Victor , Grateau Stéphane , Moreau-Vauzelle Carole , Raboteau Daniel , Chevallereau Colombe , Requier Fabrice , Aupinel Pierrick , Richard Freddie-Jeanne 
Published: April 2024

Abstract
Apis mellifera was used as a model species for ecotoxicological testing. In the present study, we tested the effects of acetone (0.1% in feed), a solvent commonly used to dissolve pesticides, on bees exposed at different developmental stages (larval and/or adult). Moreover, we explored the potential effect of in vitro larval rearing, a commonly used technique for accurately monitoring worker exposure at the larval stage, by combining acetone exposure and treatment conditions (in vitro larval rearing vs. in vivo larval rearing). We then analyzed the life-history traits of the experimental bees using radio frequency identification technology over three sessions (May, June, and August) to assess the potential seasonal dependence of the solvent effects. Our results highlight the substantial influence of in vitro larval rearing on the life cycle of bees, with a 47.7% decrease in life span, a decrease of 0.9 days in the age at first exit, an increase of 57.3% in the loss rate at first exit, and a decrease of 40.6% in foraging tenure. We did not observe any effect of exposure to acetone at the larval stage on the capacities of bees reared in vitro. Conversely, acetone exposure at the adult stage reduced the bee life span by 21.8% to 60%, decreased the age at first exit by 1.12 to 4.34 days, and reduced the foraging tenure by 30% to 37.7%. Interestingly, we found a significant effect of season on acetone exposure, suggesting that interference with the life-history traits of honey bees is dependent on season. These findings suggest improved integration of long-term monitoring for assessing sublethal responses in bees following exposure to chemicals during both the larval and adult stages. Environ Toxicol Chem 2024;43:1320–1331. © 2024 The Authors. Environmental Toxicology and Chemistry published by Wiley Periodicals LLC on behalf of SETAC.
Forecasting Chinese crude oil futures volatility: New evidence based on dual feature processing of large‐scale variables
Authors: Qiao Gaoxiu , Pan Yijun , Liang Chao , Wang Lu , Wang Jinghui 
Published: April 2024

AbstractThis paper aims to study the volatility forecasting of Chinese crude oil futures from the large‐scale variables perspective by considering both the information on international futures markets volatility and technical indicators of Chinese crude oil futures. We employ the dual feature processing method (LASSO‐PCA) by integrating least absolute shrinkage and selection operator (LASSO) and principal component analysis (PCA) to extract important factors of the large‐scale exogenous variables. Besides the traditional ordinary least squares (OLS) estimation, the nonlinear support vector regression (SVR) approach is employed to integrate with the LASSO‐PCA method. The empirical results show that both the OLS and SVR combined with LASSO‐PCA can improve the forecasting accuracy, especially SVR‐LASSO‐PCA owns the best forecasting performance. The analysis of the selected variables finds international futures volatility is chosen more frequently. These results are further validated through a series of robust experiments. Finally, the time difference between China and the United States is also considered in order to obtain more reasonable out‐of‐sample forecasting.
A comparative analysis of the nutrient and phytochemical richness among different varieties of quinoa in China
Authors: Tang Yuan‐Mou , Liu Yi‐Zhi , Zhang Yan‐Hong , Cao Ya‐Nan , Song Pan‐Pan , Hou Li‐Ming , Peng Lian‐Xin 
Published: April 2024

AbstractQuinoa is a nutrient‐dense pseudocereal that has garnered global attention for its potential to bolster food security and nutrition. Despite its celebrated status, the detailed nutritional profiles of various quinoa varieties remain poorly understood, which poses a significant barrier to the strategic cultivation and utilization of quinoa's genetic diversity to combat malnutrition. The impetus for this research lies in the urgent need to identify superior quinoa strains that can be tailored to meet specific nutritional requirements and adapt to diverse agro‐ecological zones. Our findings reveal substantial variation in nutrient content across different quinoa varieties, highlighting the variety ZLZX‐8 as a particularly nutrient‐rich strain with the highest levels of protein, fat, essential fatty acids, amino acids, and key minerals such as Mg, K, and Zn. Moreover, ZLZX‐8's exceptional antioxidant capacity suggests it may have additional health benefits beyond its macronutrient profile. In contrast, ZLZX‐7 stands out for its dietary fiber and phenolic content, which are critical for digestive health and disease prevention, respectively. Meanwhile, ZLZX‐5, with its high starch content, could be better suited for energy production in dietary applications. Notably, the study also uncovers a correlation between grain color and nutrient profile, with colored quinoa varieties exhibiting superior fiber, inositol, phenolic content, and antioxidant activity compared to their white counterparts. This work lays the groundwork for an informed selection of quinoa varieties that can enhance dietary quality, support local and global food systems, and contribute to the fight against malnutrition.
Real‐life study on the use of response adapted therapy in patients with Hodgkin Lymphoma: Results from a multicenter experience
Authors: Zilioli Vittorio Ruggero , Cencini Emanuele , Lorenzo Sonya De , Pezzullo Luca , Merli Michele , Rivellini Flavia , Muzi Cristina , Emiliano Barbieri , Marcheselli Luigi , Luminari Stefano 
Published: April 2024

AbstractFew data are known regarding the use of interim positron emission tomography (iPET) after the first two cycles (iPET2) of chemotherapy in treatment‐naïve classical Hodgkin lymphoma (cHL) in routine clinical practice, and about the real‐life adoption of intensification strategies for iPET positive patients. We conducted a multicenter retrospective study on cHL to investigate the use of iPET in the real‐life setting, its prognostic role and outcomes of patients early shifted to intensification. Six hundreds and forty‐one patients were enrolled (62% had advanced stage). iPET2 was positive in 89 patients (14%) including 8.7% and 17% early and advanced stage patients, respectively (p = 0.003). Among iPET 2 positive cases treatment was immediately modified in 19 cases; in 14 cases treatment was modified after an additional positive iPET4. Overall 56 iPET2 positive patients never received intensified therapies. Most frequently used intensified therapy was autologous stem cell transplantation followed by BEACOPP. After a median follow‐up of 72 months, the 5‐year progression‐free survival (PFS) was 82% with iPET2 positive patients showing a worse PFS compared with iPET2 negative cases: 31% versus 85%. Focusing on advanced stage patients with a positive iPET2, the 5‐year PFS was 59% for patients shifted to intensified therapy at any time point versus 61% for patients who never received intensified therapy. Our study confirmed the higher curability of naïve cHL patients in a real‐world setting, and the prognostic role of iPET2 in this setting. A poor adherence to response‐adapted strategy which however did not translate into a difference in patient outcomes.
Genes involved in metastasis in oral squamous cell carcinoma: A systematic review
Authors: Mohtasham Nooshin , Zarepoor Marzieh , Shooshtari Zahra , Hesari Kiana Kamyab , Mohajertehran Farnaz 
Published: April 2024

AbstractBackground and AimsOral squamous cell carcinoma is the most prevalent malignancy in the oral cavity, with a significant mortality rate. In oral squamous cell carcinoma patients, the survival rate could decrease because of delayed diagnosis. Thus, prevention, early diagnosis, and appropriate treatment can effectively increase the survival rate in patients. In this systematic review, we discussed the role of different genes in oral squamous cell carcinoma metastasis. Herein, we aimed to summarize clinical results, regarding the potential genes that promote oral squamous cell carcinoma metastasis.MethodsThis systematic review was carried out under the Preferred Reporting Items for Systematic Reviews and Meta‐Analysis guidelines. An electronic search for all relevant articles published in English between January 2018 and April 2022 was performed using Scopus, PubMed, and Google Scholar search engines. All original studies published in English were included, and we excluded studies that were in a non‐English language.ResultsA total of 4682 articles were found, of which 14 were relevant and detected significant genes in oral squamous cell carcinoma progression. These findings investigated the overexpression of interferon‐induced proteins with tetratricopeptide repeats 1 and 3 (IFIT1, IFT3), high‐mobility group A2 (HMGA2), transformed growth factor‐beta‐induced, lectin galactoside‐binding soluble 3 binding protein (LGALS3BP), bromodomain containing 4, COP9 signaling complex 6, heterogeneous nuclear ribonucleoproteins A2B1 (HNRNPA2B1), 5′−3′ exoribonuclease 2 (XRN2), cystatin‐A (CSTA), fibroblast growth factors 8 (FGF8), forkhead box P3, cadherin‐3, also known as P‐cadherin and Wnt family member 5A, ubiquitin‐specific‐processing protease 7, and retinoic acid receptor responder protein 2 genes lead to promote metastasis in oral squamous cell carcinoma. Overexpression of some genes (IFIT1, 3, LGALS3BP, HMGA2, HNRNPA2B1, XRN2, CSTA, and FGF8) was proven to be correlated with poor survival rates in oral squamous cell carcinoma patients.ConclusionStudies suggest that metastatic genes indicate a poor prognosis for oral squamous cell carcinoma patients. Detecting these metastatic genes in oral squamous cell carcinoma patients may be of predictive value and can also facilitate assessing oral squamous cell carcinoma development and its response to treatment.
Vogt–Koyanagi–Harada disease after SARS‐CoV‐2 infection: Case report and literature review
Authors: Zou Hui , Zhang Ke , Chen Xuan , Sha Sha 
Published: April 2024

AbstractBackgroundSevere acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) is responsible for coronavirus disease 2019 (COVID‐19), a complex and multifaceted illness. COVID‐19 is associated with various ocular manifestations including conjunctivitis, retinal vein occlusion and optic neuritis. However, the case of Vogt‐Koyanagi‐Harada (VKH) disease associated with SARS‐CoV‐2 is infrequent, and the specific association is still unclear.Case PresentationIn the present study, a 35‐year‐old female patient without any significant medical history presented with 1 week of bilateral blurred vision, occurring 2 weeks after a clinical course of COVID‐19. Upon examination, both eyes exhibited bullous serous retinal detachments. She was diagnosed with incomplete VKH disease. Early diagnosis and treatment of VKH disease are essential for the visual prognosis of this aggressive disease. In this particular patient, ocular inflammatory signs and visual acuity improved via corticosteroid therapy. It is worth noting that the occurrence of VKH disease associated with SARS‐CoV‐2 is uncommon, and the specific connection between the two remains unknown. We review and summarize the clinical characteristics of VKH disease following SARS‐CoV‐2 infection, and discuss the potential mechanisms that may explain this phenomenon, based on similar studies previously reported.ConclusionDespite the unclear causality, it is important for ophthalmologists and physicians to be recognizant of the possible association between VKH disease and COVID‐19. SARS‐CoV‐2 may play a potential immunological triggering role in VKH disease. However, further in‐depth research is necessary to investigate the clinical and epidemiological features, as well as the underlying mechanisms of this association.
Maternal awareness, acceptability and willingness towards respiratory syncytial virus (RSV) vaccination during pregnancy in Ireland
Authors: McCormack Siobhan , Thompson Claire , Nolan Miriam , Imcha Mendinaro , Dee Anne , Saunders Jean , Philip Roy K 
Published: April 2024

AbstractBackgroundRespiratory syncytial virus (RSV) is the world's leading cause of viral acute lower respiratory infections (ALRI) in infants. WHO has identified maternal RSV vaccination a priority and candidate vaccines are in development; however, vaccine hesitancy remains an impediment to successful implementation of maternal immunization. This study, the largest antenatal survey conducted to‐date, aimed to examine maternal RSV awareness, likely acceptance of RSV vaccination in pregnancy, and attitudes to maternal vaccination.MethodsPregnant women of all gestations attending antenatal clinic of a university maternity hospital in Ireland were invited to participate. An information leaflet provided, consent obtained, and survey administered examining RSV awareness, willingness to avail of antenatal RSV vaccination, factors influencing acceptability and preferred sources of assistance. Research Ethics Committee (REC) approval obtained, and general data protection regulation (GDPR) guidelines followed.Results528 women completed the survey. A large proportion (75.6%) had never heard of RSV, yet 48.5% would still avail of a vaccine, 45.8% were undecided and only 5.3% would not. The main factor making vaccination acceptable to women (76.4%) was that it protects their infant from illness (p < .001, CV 0.336 for association with acceptance) and general practitioner (GP) was the preferred guidance source in decision‐making (57.7%).ConclusionsDespite low levels of maternal awareness of RSV, pregnant women in Ireland are open to availing of antenatal vaccination. Maternal immunization strategies need to focus on infant's protection from RSV‐associated ALRI along with vaccine safety, and build on an interdisciplinary collaboration of maternal, neonatal, primary care and public health services.
Successful treatment of eosinophilia associated with dialysis‐related renal cancer with radical nephrectomy
Authors: Goto Yuta , Tamura Daichi , Matsuura Tomohiko , Shiomi Ei , Ikarashi Daiki , Maekawa Shigekatsu , Kato Renpei , Kanehira Mitsugu , Obara Wataru 
Published: April 2024

IntroductionSecondary eosinophilia due to solid tumors is a rare case. This is the first study to report secondary eosinophilia due to renal cancer in a patient on dialysis.Case presentationA 70‐year‐old man, on long‐term hemodialysis was incidentally detected with right renal cancer, and workup performed revealed eosinophilia. Allergic symptoms caused by hemodialysis were initially considered; however, treatment did not lead to any improvement in eosinophilia. Therefore, nephrectomy for renal cancer was performed. The resolution of symptoms and eosinophilia after surgery suggested renal cancer as the cause of eosinophilia.ConclusionAs demonstrated in this patient with dialysis‐related renal cancer, eosinophilia associated with solid tumors may be addressed by treating the tumor.
Candidate reference measurement procedure for serum 17‐hydroxyprogesterone quantification via isotope dilution liquid chromatography–tandem mass spectrometry
Authors: Zhang Ji , Jiang Yang , Liu Ting , Liu Xiongwei , Huang Hui , Cheng Yanxiang , Li Jieyan , Cheng Bangning , Qian Chungen , Xiang Xufu , Xu Jun‐Fa 
Published: April 2024

AbstractBackgroundAccurate quantification of 17‐hydroxyprogesterone (17‐OHP) in serum is vital for clinical and research applications. However, inter‐laboratory variability in test results exists owing to the lack of a standardized reference measurement procedure (RMP). Therefore, in this study, we developed a highly accurate, cost‐effective, and user‐friendly candidate RMP (cRMP) for analyzing 17‐OHP in serum.MethodsWe quantified 17‐OHP in serum using a one‐step liquid–liquid extraction method with the addition of 17‐OHP‐13C3, followed by liquid chromatography–tandem mass spectrometry. The ability of these methods to suppress interference was evaluated by chromatographic analysis. We assessed accuracy, specificity, the lower limit of quantitation, linearity, and matrix effects by following the standards specified by the Clinical and Laboratory Standards Institute. The consistency between the developed cRMP and the chemiluminescence method was evaluated through experiments with 120 clinical samples.ResultsThe developed cRMP required only 8 min for accurate quantification of serum 17‐OHP without bias from matrix effects or interference from 19 metabolites added as potential interferents. The method exhibited favorable measurement performance, with a quantitation limit of 0.086 ng/mL, linear range of 0.1–400 ng/mL, a total imprecision of ≤2.90%, spike recovery of 100.1%–100.6%, and relative deviations from assigned target values (RfB Institution) of −2.91% to 1.10%. The cRMP demonstrated good consistency with the conventional assay (chemiluminescence method), with a correlation coefficient R of 0.96977.ConclusionA cRMP with high accuracy, cost‐effectiveness, and convenient operation was developed for quantifying 17‐OHP in serum. Its simplicity and robust performance make it an invaluable addition to the arsenal of analytical tools available for laboratories. This method can enhance the accuracy and reliability of 17‐OHP measurements across various laboratories.