bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pre‐ and postnatal developmental toxicity study design for pharmaceuticals
Authors: Bailey Graham P. , Wise L. David , Buschmann Jochen , Hurtt Mark , Fisher J. Edward 
Published: December 2009

AbstractAssessment of potential developmental and reproductive toxicity of human pharmaceuticals is currently guided by the ICH S5(R2) document. The studies that assess the hazard of both pre‐ and postnatal exposure are predominantly conducted in rodents (rat and mouse). Utilizing the collective experience of the authors, acceptable designs for both the range‐finding and definitive studies are presented with detailed descriptions for the presentation of data. In addition, the suggested initiation and then total duration of these studies in relation to clinical studies are described. Optional parameters that may be included in the studies, as well as possible combination with other study designs are discussed. The details described herein will assist all laboratories performing these studies, individuals who need to plan for the studies, and regulatory agencies that ultimately review these studies. Birth Defects Res (Part B) 86:437–445, 2009. © 2009 Wiley‐Liss, Inc.
Juvenile animal toxicity study designs to support pediatric drug development
Authors: Cappon Gregg D. , Bailey Graham P. , Buschmann Jochen , Feuston Maureen H. , Fisher J. Edward , Hew Kok Wah , Hoberman Alan M. , Ooshima Yojiro , Stump Donald G. , Hurtt Mark E. 
Published: December 2009

AbstractThe objective of juvenile animal toxicity studies of pharmaceuticals is to obtain safety data, including information on the potential for adverse effects on postnatal growth and development. Studies in juvenile animals may assist in identifying postnatal developmental toxicities or other adverse effects that are not adequately assessed in the routine toxicity evaluations and that cannot be safely or adequately measured in pediatric clinical trials. Unlike the traditional reproductive and developmental toxicology studies that have been discussed in the accompanying reports, the design requirements for toxicity studies in juvenile animals are not explicitly defined in regulatory guidance. However, studies in juvenile animals can be useful in providing safety information necessary to enable pediatric clinical trials in pediatric patients or when there are special concerns for toxicities that cannot be safely or adequately measured in clinical trials. These juvenile animal toxicity studies are designed on a case‐by‐case basis. General design considerations and examples of study designs for assessment of juvenile animal toxicity are discussed. Birth Defects Res (Part B) 86:463–469, 2009. © 2009 Wiley‐Liss, Inc.
The nonclinical fertility study design for pharmaceuticals
Authors: Lerman Steven A. , Hew Kok Wah , Stewart Jane , Stump Donald G. , Wise L. David 
Published: December 2009

AbstractAssessment of potential developmental and reproductive toxicity of human pharmaceuticals is currently guided by the ICH S5(R2) document, “Detection of Toxicity to Reproduction for Medicinal Products and Toxicity to Male Fertility.” Studies that assess a candidate drug's effect on fertility are generally conducted in rats. The evolution of, and ultimate harmonization of, fertility study designs are reviewed, and specific elements of an acceptable design, as well as the recommendations for presentation of data, are described in detail. Additionally, the timing of nonclinical fertility studies in relation to clinical studies that enroll men and women of reproductive potential is reviewed. Possible strategies for combining fertility assessment with other study designs are also presented. This article provides testing laboratories, sponsors, and regulatory agencies with a comparison of current methods and designs, with the aim of providing a common understanding of the critical design features. Birth Defects Res (Part B) 86:429–436, 2009. © 2009 Wiley‐Liss, Inc.
DNA microarrays to define and search for genes associated with obesity
Authors: Kim Yunjung , Park Taesun 
Published: December 2009

AbstractOne of the major goals of this review was to identify obesity‐specific gene profiles in animal models to help comprehend the pathogenic mechanisms and the prediction of the phenotypic outcomes of obesity and its associated metabolic diseases. The genomic examination of insulin‐sensitive tissues, such as the adipose and hepatic tissues, has provided a wealth of information about the changes in gene expression in obesity and its associated metabolic diseases. The overexpression of genes related to inflammation, immune response, adhesion molecules, and lipid metabolism is a major characteristic of white adipose tissue, while the overexpression of the genes related to lipid metabolism, adipocyte differentiation, defense, and stress responses is noticeable in the non‐alcoholic fatty liver of obese rodents. The hepatic‐gene expression profiles led us to hypothesize that in obese rodents, the livers are supplied with large amounts of free fatty acids under conditions associated with obesity either through increased fatty acid biosynthesis or through decreased fatty acid oxidation, which may lead to increased mitochondrial respiratory activity. The wide list of genes that were identified in previous studies could be a source of potential therapeutic targets because most of these genes are involved in the key mechanisms of obesity development, from adipocyte differentiation to the disturbance of metabolism.
Closure of ostium secundum atrial septum defect with the Atriasept occluder: Early European experience
Authors: Stolt Valérie Steiger , Chessa Massimo , Aubry Pierre , Juliard Jean‐Michel , Schraeder Rainer , Berger Alexandre , Goy Jean‐Jacques 
Published: December 2009

AbstractObjectives: This multicentre study sought to report the safety and efficacy of the ATRIASEPT septal occluder to repair atrial septal defect (ASD). Background: The ATRIASEPT is a low profile, flexible, double disk occluder with centering system specifically designed for closure of ostium secundum ASD. Method: Patients were enrolled from four participating European sites and followed up for 12 months post procedure. Outcomes were evaluated, including closure success and incidence of adverse events. Results: Seventy‐six patients received the ATRIASEPT device. Mean size of the defect was 15 ± 4 mm. Closure success was observed in 69 patients (89%) at the end of the procedure. Sixty‐four patients had a six‐month follow up with a complete closure by 58 patients (90%). Minor adverse events occurred in two patients. Significant functional improvement was reported by all symptomatic patients. Conclusion: Percutaneous closure of ASD ostium secundum type defects with the ATRIASEPT is safe and effective with high success rate and excellent mid‐term outcome. © 2010 Wiley‐Liss, Inc.
Long‐term complication after LM bifurcation treatment
Authors: Wainstein Marco V. , Ribeiro Jorge P. 
Published: December 2009

AbstractTwo months after left anterior descending (LAD) artery and left circumflex (LCx) artery bare metal stent implantation, a proliferative subocclusive in‐stent restenosis in LCx coronary with severe LM coronary (LM) involvement developed. The present clinical case describes a simplified strategy for unprotected LM percutaneous coronary intervention using two bioabsorbable biolimus‐eluting stents without involvement of the LAD coronary using an “L” technique. © 2010 Wiley‐Liss, Inc.
Is the left anterior descending artery really absent?—A decisive input from coronary CT angiography
Authors: Hacioglu Yalcin , Budoff Matthew 
Published: December 2009

AbstractThis case report emphasizes the importance of coronary CT angiography (CTA) as a backup imaging modality in patients with suspected coronary anomalies and difficult canulation, during invasive coronary angiography by catheterization (Cath). In this patient, the numerous canulation attempts during Cath failed to identify a left anterior descending artery (LAD) leading to the diagnosis of absent LAD. CTA was done for further clarification, which easily visualized LAD originating from a separate ostium at the left sinus of Valsalva finalizing the diagnosis as absent left main artery with dual left coronary ostia. © 2010 Wiley‐Liss, Inc.
Covered stent to treat saphenous venous graft perforation—A case report
Authors: Baruah D.K. 
Published: December 2009

AbstractThis case report shows the immediate and long‐term clinical result of percutaneous coronary intervention in a patient with total occlusion of saphenous venous graft. The case also highlights the management of venous graft perforation during percutaneous intervention using a covered stent. © 2010 Wiley‐Liss, Inc.
Long‐term follow‐up after nonurgent percutaneous coronary intervention in unprotected left main coronary arteries
Authors: Beijk Marcel A.M. , Rittersma Saskia Z.H. , Koch Karel T. , Henriques José P.S. , Baan Jan , Vis Marije M. , Hoekstra Fokje , Tijssen Jan G.P. , Piek Jan J. , Kloek Jaap J. , de Mol Bas A.J.M. , de Winter Robbert J. 
Published: December 2009

AbstractObjectives: To evaluate the long‐term outcomes of the selected patients by the local Heart Team to undergo percutaneous coronary intervention (PCI) of unprotected left main coronary artery (ULMCA) stenosis and to compare patients considered at low surgical risk versus at high surgical risk for coronary artery bypass grafting (CABG). Background: CABG is recommended in patients with ULMCA stenosis according to the AHA/ACC and ESC guidelines, and there are limited data on the long‐term outcomes in patients selected by the local Heart Team to undergo PCI. Methods: Between 1996 and 2007, 227 patients underwent PCI for ULMCA stenosis based on decision of the local Heart Team and patient's and/or physician's preference. All patients were contacted at 1 year and in November 2008. Results: Long‐term follow‐up was up to 8 years with a mean of 3.9 ± 2.6 years. Overall, the Kaplan–Meier estimate of the composite of cardiac death, myocardial infarction (MI), or target lesion revascularization (TLR) was 14.8% at 1 year, 18.3% at 3 years, and 20.9% at 5 years with no events occurring thereafter. Patients considered at low surgical risk for CABG had a significantly lower incidence of cardiac death or MI compared to patients considered at high surgical risk at 8 years (1.4 vs. 16.8%; 1.4 vs. 14.8%, respectively); however, no significant difference was observed for cardiac death, MI, or TLR (18.6 vs. 24.4%). Conclusions: PCI of ULMCA stenosis in patients selected by the Heart Team resulted in good long‐term clinical outcomes with most events occurring within the 1st year. Patients considered at low surgical risk for CABG have a significantly better long‐term survival than patients at high risk for surgery. © 2010 Wiley‐Liss, Inc.
Efficient Intramolecular Charge Transfer in Oligoyne‐Linked Donor–π–Acceptor Molecules
Authors: Pålsson Lars‐Olof , Wang Changsheng , Batsanov Andrei S. , King Simon M. , Beeby Andrew , Monkman Andrew P. , Bryce Martin R. 
Published: December 2009

AbstractStudies are reported on a series of triphenylamine–(CC)n–2,5‐diphenyl‐1,3,4‐oxadiazole dyad molecules (n=1–4, 1, 2, 3 and 4, respectively) and the related triphenylamine‐C6H4–(CC)3–oxadiazole dyad 5. The oligoyne‐linked D–π–A (D=electron donor, A=electron acceptor) dyad systems have been synthesised by palladium‐catalysed cross‐coupling of terminal alkynyl and butadiynyl synthons with the corresponding bromoalkynyl moieties. Cyclic voltammetric studies reveal a reduction in the HOMO–LUMO gap in the series of compounds 1–4 as the oligoyne chain length increases, which is consistent with extended conjugation through the elongated bridges. Photophysical studies provide new insights into conjugative effects in oligoyne molecular wires. In non‐polar solvents the emission from these dyad systems has two different origins: a locally excited (LE) state, which is responsible for a π*→π fluorescence, and an intramolecular charge transfer (ICT) state, which produces charge‐transfer emission. In polar solvents the LE state emission vanishes and only ICT emission is observed. This emission displays strong solvatochromism and analysis according to the Lippert–Mataga–Oshika formalism shows significant ICT for all the luminescent compounds with high efficiency even for the longer more conjugated systems. The excited‐state properties of the dyads in non‐polar solvents vary with the extent of conjugation. For more conjugated systems a fast non‐radiative route dominates the excited‐state decay and follows the Engelman–Jortner energy gap law. The data suggest that the non‐radiative decay is driven by the weak coupling limit.
Systematic Investigation of Photoinduced Electron Transfer Controlled by Internal Charge Transfer and Its Consequences for Selective PdCl2 Coordination
Authors: Schwarze Thomas , Mickler Wulfhard , Dosche Carsten , Flehr Roman , Klamroth Tillmann , Löhmannsröben Hans‐Gerd , Saalfrank Peter , Holdt Hans‐Jürgen 
Published: December 2009

AbstractFluoroionophores of fluorophore–spacer–receptor format were prepared for detection of PdCl2 by fluorescence enhancement. The fluorescent probes 1–13 consist of a fluorophore group, an alkyl spacer and a dithiomaleonitrile PdCl2 receptor. First, varying the length of the alkylene spacer (compounds 1–3) revealed a dominant through‐space pathway for oxidative photoinduced electron transfer (PET) in CH2‐bridged dithiomaleonitrile fluoroionophores. Second, fluorescent probes 4–9 containing two anthracene or pyrene fragments connected through CH2 bridges to the dithiomaleonitrile unit were synthesized. Modulation of the oxidation potential (EOx) through electron‐withdrawing or ‐donating groups on the anthracene moiety regulates the thermodynamic driving force for oxidative PET (ΔGPET) in bis(anthrylmethylthio)maleonitriles and therefore the fluorescence quantum yields (Φf), too. The new concept was confirmed and transferred to pyrenyl ligands, and fluorescence enhancements (FE) greater than 3.2 in the presence of PdCl2 were achieved by 7 and 8 (FE=5.4 and 5.2). Finally, for comparison, monofluorophore ligands 10–13 were synthesized.
The Sequential Building of Chiral Macrocyclic Bis‐β‐Lactams by Double Staudinger–Cu‐Catalyzed Azide–Alkyne Cycloadditions
Authors: Pellico Daniel , Gómez‐Gallego Mar , Ramírez‐López Pedro , Mancheño María José , Sierra Miguel A. , Torres M. Rosario 
Published: December 2009

AbstractA novel approach for the synthesis of macrocyclic bis‐β‐lactams based on the Cu‐catalyzed alkyne–azide cycloaddition (CuAAC) is reported. The procedure is general and allows access to a full range of diastereomerically or enantiomerically pure macrocyclic cavities in good yields. The incorporation of chiral oxazolidinone fragments at C3 in the β‐lactam rings allows the total enantiocontrol of the process.
ChemInform Abstract: Tuning of Metal—Metal Bonding by Counterion Size in Hypothetical AeTiO2 Compounds.
Authors: Wen Xiao‐Dong , Cahill Thomas J. , Hoffmann Roald , Miura Akira 
Published: December 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Slater—Pauling Behavior within Quaternary Intermetallic Borides of the Ti3Co5B2 Structure‐Type.
Authors: Burghaus Jens , Dronskowski Richard , Miller Gordon J. 
Published: December 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Compositional Control of Electrical Transport Properties in the New Series of Defect Thiospinels, Ga1‐xGexV4S8‐δ (0 ≤ x ≤1).
Authors: Szkoda Iwona , Vaqueiro Paz , McDowall Andrew , Powell Anthony V. , Ritter Clemens 
Published: December 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Syntheses, Crystal Structures and Raman Spectra of Ba(BF4)(PF6), Ba(BF4)(AsF6) and Ba2(BF4)2(AsF6) (H3F4). The First Examples of Metal Salts Containing Simultaneously Tetrahedral BF‐4 and Octahedral AF‐6 Anions.
Authors: Lozinsek Matic , Bunic Tina , Goreshnik Evgeny , Meden Anton , Tramsek Melita , Tavcar Gasper , Zemva Boris 
Published: December 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis and Aqueous Colloidal Solutions of Ln2(OH)5NO3·nH2O (Ln: Nd and La).
Authors: Lee Kyung‐Hee , Byeon Song‐Ho 
Published: December 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: 2D Water Layer Enclathrated Between Mn(II)—Ni(CN)4 Coordination Frameworks.
Authors: Ray Ambarish , Bhowmick Indrani , Sheldrick William S. , Jana Atish Dipankar , Ali Mahammed 
Published: December 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Crystal Structure and Thermal Expansion Properties of New Compound La2Cu0.8Ge3.
Authors: Yan Jialin , Lu Xingwen , Shen Wenjun , Zeng Lingmin , Nong Liangqin 
Published: December 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Catalytic Asymmetric Intermolecular Stetter Reaction of Heterocyclic Aldehydes with Nitroalkenes: Backbone Fluorination Improves Selectivity.
Authors: DiRocco Daniel A. , Oberg Kevin M. , Dalton Derek M. , Rovis Tomislav 
Published: December 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Iridium‐Catalyzed X—H Insertions of Sulfoxonium Ylides.
Authors: Mangion Ian K. , Nwamba Ikenna K. , Shevlin Michael , Huffman Mark A. 
Published: December 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Cesium Salt‐Catalyzed Addition of Diphenyl Dichalcogenides to Alkynes: Selective Synthesis of Bis‐ and Mono(phenylchalcogeno)alkenes.
Authors: Nishiyama Yutaka , Ohnishi Haruko , Koguma Yuya 
Published: December 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Rhodium‐Catalyzed Oxidative Coupling of Aromatic Imines with Internal Alkynes via Regioselective C—H Bond Cleavage.
Authors: Fukutani Tatsuya , Umeda Nobuyoshi , Hirano Koji , Satoh Tetsuya , Miura Masahiro 
Published: December 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: A Metal‐Free General Procedure for Oxidation of Secondary Amines to Nitrones.
Authors: Gella Carolina , Ferrer Eric , Alibes Ramon , Busque Felix , de March Pedro , Figueredo Marta , Font Josep 
Published: December 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: An Efficient and Convenient Transformation of α‐Haloketones to α‐Hydroxyketones Using Cesium Formate.
Authors: Wong Fung Fuh , Chang Po‐Wei , Lin Hui‐Chang , You Bang‐Jau , Huang Jiann‐Jyh , Lin Shao‐Kai 
Published: December 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Asymmetric Reduction of Imines with Trichlorosilane, Catalyzed by Sigamide, an Amino Acid‐Derived Formamide: Scope and Limitations.
Authors: Malkov Andrei V. , Vrankova Kvetoslava , Stoncius Sigitas , Kocovsky Pavel 
Published: December 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Preparation of Several Active N‐Chloro Compounds from Trichloroisocyanuric Acid.
Authors: Shiri Azam , Khoramabadi‐zad Ahmad 
Published: December 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: IBX—I2 Redox Couple for Facile Generation of IOH and I+: Expedient Protocol for Iodohydroxylation of Olefins and Iodination of Aromatics.
Authors: Moorthy Jarugu Narasimha , Senapati Kalyan , Kumar Sarvesh 
Published: December 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.