bluuebunny/crossref_metadata_2025_split huggingface dataset:
Muslinoma and muslin-induced foreign body inflammatory reactions after surgical clipping and wrapping for intracranial aneurysms: imaging findings and clinical features
Authors: Yoon Min A. , Kim Eunhee , Kwon Bae-Ju , Kim Jeong Eun , Kang Hyun-Seung , Park Jae Hyo , Sohn Chul-Ho , Kim Ji-Hoon , Lee Dong Hoon 
Published: September 2009

Object
Reinforcement of aneurysms with additional wrapping is an alternative procedure if the aneurysm cannot be completely clipped. Wrapping with muslin (cotton gauze) rarely incites foreign body inflammatory reactions. In this study, the authors describe the clinical and radiological features of muslinomas or muslin-induced foreign body reactions that can develop after treatment of intracranial aneurysms.

Methods
Over a 3-year period, 5 patients with muslinomas underwent treatment at the authors' institution. All patients underwent aneursym clipping and wrapping, and were subsequently readmitted with acute or subacute neurological symptoms. Clinical and imaging features on diffusion weighted MR images and cerebral angiography images were retrospectively reviewed. The patients' clinical course and follow-up imaging studies were also evaluated.

Results
In all 5 cases, muslinomas were seen as rim-enhancing inflammatory masses around the clipped aneurysms with perilesional edema visible on MR images at the time of clinical deterioration. The MR images also demonstrated adhesive arachnoiditis with a sterile intracranial abscess in 3 patients, optic neuropathy in 2, parent artery narrowing in 2, and a resultant acute ischemic infarction in 1 patient. Follow-up imaging revealed resolution of both the perilesional edema and adhesive arachnoiditis but no significant changes in the muslinomas. All patients underwent conservative management and fully recovered, but during the follow-up period, 2 patients experienced clinical and radiological relapses.

Conclusions
When a patient with a history of wrapping of an aneurysm presents with acute neurological symptoms and an enhancing intracranial mass in the region of the surgical site on MR imaging, a muslin-induced foreign body inflammatory reaction should be considered in the differential diagnosis, and careful clinical and radiological follow-up is advised.
Therapeutic management of intracranial dural arteriovenous shunts with leptomeningeal venous drainage: report of 53 consecutive patients with emphasis on transarterial embolization with acrylic glue
Authors: Guedin Pierre , Gaillard Stephan , Boulin Anne , Condette–Auliac Stephanie , Bourdain Frederic , Guieu Stephanie , Dupuy Michel , Rodesch Georges 
Published: September 2009

Object
There is a strong correlation between the venous drainage pattern of intracranial dural arteriovenous shunts (ICDAVSs) and the affected patients' clinical presentation. The ICDAVSs that have cortical venous reflux (CVR) (retrograde leptomeningeal drainage: Borden Type 2 and 3 lesions) are very aggressive and have a poor natural history. Although the necessity of treatment remains debatable in ICDAVSs that drain exclusively into a sinus (Borden Type 1), lesions with CVR must be treated because of the negative effects of the retrograde venous drainage. Surgery, radiosurgery, and embolization have been proposed for management of these lesions, but endovascular therapy is considered the most appropriate therapeutic strategy in ICDAVSs. New embolic materials, such as Onyx, have been recently developed and are considered to represent a kind of “gold standard” for embolization of these lesions. The purpose of this study is to emphasize the importance of transarterial embolization using acrylic glue in the therapeutic management of ICDAVSs with CVR, and to compare the results the authors obtained using this treatment with those reported in the literature for Onyx treatment of the same type of dural shunts.

Methods
The clinical and radiological records of 53 consecutive patients suffering from ICDAVSs with CVR (Borden Types 2 or 3) were reviewed. All cases were managed with the same angiographic and therapeutic protocol. Localization of the lesions, their clinical symptoms, their angioarchitecture, their therapeutic management, and the results were analyzed.

Results
Fourteen ICDAVSs were located at the superior sagittal sinus and/or convexity veins, 13 at the transverse and sigmoid sinuses, 10 at the tentorium, 5 in the anterior cranial fossa, 4 at the foramen magnum, 3 at the torcula, 2 at the straight sinus, and 1 at the vein of Galen. One patient presented with an infantile form of ICDAVS with multiple shunts. Hemorrhage had occurred in 36% of cases. Forty-three patients underwent transarterial embolization (42 with acrylic glue). Complete closure of the fistula was obtained in 34 patients. Suppression of the CVR with partial occlusion of the main shunt was achieved in all other cases. No mortality or permanent morbidity was observed in this series.

Conclusions
Intracranial dural arteriovenous shunts can be safely managed by transarterial embolization, which can be considered in most instances as an effective first-intention treatment. Acrylic glue still allows a cheap, fast, and effective treatment with high rates of cures that compare favorably to those obtained with new embolic materials.
Male Breast Cancer- Report of Two Cases
Authors: Uddin M Dayem , Hannan ABM Abdul 
Published: September 2009

Male breast cancer is rare. It accounts for 0.2% of all cancers, and 1% all breast cancers. Most patients present late for several reasons, including the absence of early signs and symptoms, and reduced awareness of the existence of such pathology among patients and physicians, Reporting these cases from among the Bangladeshi population, we tried to observe any differences in clinical manifestation from those reported in the literature, and aimed to increase the value assigned to male breast as a source of pathology among patients and physicians as well. doi: 10.3329/taj.v21i1.3226 TAJ 2008; 21(1): 80-82
Andropause: The Male Climacterium
Authors: Kabir M Rizaul , Al-Amin MA , Siddique M Afsar 
Published: September 2009

Andropause is a clinical condition characterized by a partial deficiency of androgens in blood and/or a decreased sensitivity in target tissues. This state of hypogonadism leads to a decline of physical energy, an altered state of well-being, a sexual dysfunction and various metabolic alterations. These issues may have deleterious effects on muscle mass, bone density, lipid profile and eventually cognitive functions. The diagnosis of andropause depends mainly on clinical features and laboratory investigations. Awareness about this condition may help to diagnosis it earlier. doi: 10.3329/taj.v21i1.3228 TAJ 2008; 21(1): 87-92
Long‐term effectiveness of eliglustat treatment: A real‐world analysis from the International Collaborative Gaucher Group Gaucher Registry
Authors: Mistry Pramod K. , Balwani Manisha , Charrow Joel , Lorber Jeremy , Niederau Claus , Carwile Jenny L. , Oliveira‐dos‐Santos Antonio , Perichon Maria Gabriela , Uslu Cil Sefika , Kishnani Priya S. 
Published: April 2024

AbstractGaucher disease type 1 (GD1) is known for phenotypic heterogeneity and varied natural history. Registrational clinical trials enrolled narrowly defined phenotypes, but greater diversity is encountered in clinical practice. We report real‐world outcomes with long‐term eliglustat treatment in adults with GD1 in the International Collaborative Gaucher Group Gaucher Registry. Among 5985 GD1 patients in the Registry as of January 6, 2023, 872 started eliglustat at ≥18 years old; of these, 469 met inclusion criteria. We compared clinical parameters at eliglustat initiation (i.e., baseline) and follow‐up in treatment‐naïve patients and used linear mixed models to estimate annual change from baseline in parameters among patients who switched to eliglustat after ≥1 year on enzyme replacement therapy. Over 4 years of follow‐up in non‐splenectomized treatment‐naïve patients, hemoglobin and platelet count increased, liver and spleen volume decreased, and total lumbar spine bone mineral density (BMD) Z‐score decreased slightly. Among non‐splenectomized switch patients, on average, hemoglobin decreased −0.030 (95% CI: −0.053, −0.008) g/dL (N = 272) and platelet count increased 2.229 (95% CI: 0.751, 3.706) × 103/mm3 (N = 262) annually up to 10 years; liver volume decreased (−0.009 [95% CI: −0.015, −0.003] MN) (N = 102) and spleen volume remained stable (−0.070 [95% CI: −0.150, 0.010] MN) (N = 106) annually up to 7 years; and total lumbar spine BMD Z‐score increased 0.041 (95% CI: 0.015, 0.066) (N = 183) annually up to 8 years. Among splenectomized switch patients, clinical parameters were stable over time. These long‐term, real‐world outcomes are consistent with the eliglustat clinical trials and emerging real‐world experience across the GD phenotypic spectrum.
Thermische und photoinduzierte Anellierungen über radikalische Kaskaden mit Arylisonitrilen: Ein Zugang zu Chinolin‐abgeleiteten Benzophospholoxiden
Authors: Banjare Shyam Kumar , Lezius Lena , Horst Elena S. , Leifert Dirk , Daniliuc Constantin G. , Alasmary Fatmah A. , Studer Armido 
Published: April 2024

AbstractIn diesem Artikel stellen wir eine Kaskade bestehend aus einer radikalischen Addition und Zyklisierung vor, um Chinolin‐basierte Benzophospholoxide aus ortho‐alkinylierten aromatischen Phosphanoxiden zu erhalten. Dabei werden verschiedene Arylisonitrile als Radikalakzeptoren und kostengünstiges tert‐Butylhydroperoxid (TBHP) als terminales Oxidationsmittel in Gegenwart einer katalytischen Menge Silberacetat verwendet. Alternativ kann die Kaskade auch über einen nachhaltigen photochemischen Ansatz unter Verwendung von 1,2,3,5‐Tetrakis(carbazol‐9‐yl)‐4,6‐dicyanobenzol (4CzIPN) als organischem Photokatalysator bei Raumtemperatur realisiert werden. Der vorgestellte modulare Ansatz zeigt eine breite Toleranz gegenüber funktionellen Gruppen und bietet einen einfachen Zugang zu komplexen P,N‐haltigen polyheterozyklischen Arenen. Diese neuartigen π‐erweiterten Benzophospholoxide besitzen interessante photophysikalische und elektrochemische Eigenschaften wie Absorption im sichtbaren Bereich, Emission und eine reversible Reduktion bei niedrigen Potentialen, weswegen sie vielversprechend für potenzielle materialwissenschaftliche Anwendungen sind. Die photophysikalischen Eigenschaften können weiterhin durch Zugabe externer Lewis‐ und Brønsted‐Säuren beeinflusst werden.
Stereoselective Entry into α,α’‐C‐Oxepane Scaffolds through a Chalcogen Bonding Catalyzed Strain‐Release C‐Septanosylation Strategy
Authors: Ma Wenpeng , Schmidt Annika , Strohmann Carsten , Loh Charles C. J. 
Published: April 2024

AbstractThe utility of unconventional noncovalent interactions (NCIs) such as chalcogen bonding has lately emerged as a robust platform to access synthetically difficult glycosides stereoselectively. Herein, we disclose the versatility of a phosphonochalcogenide (PCH) catalyst to facilitate access into the challenging, but biologically interesting 7‐membered ring α,α’‐C‐disubstituted oxepane core through an α‐selective strain‐release C‐glycosylation. Methodically, this strategy represents a switch from more common but entropically less desired macrocyclizations to a thermodynamically favored ring‐expansion approach. In light of the general lack of stereoselective methods to access C‐septanosides, a remarkable palette of silyl‐based nucleophiles can be reliably employed in our method. This include a broad variety of useful synthons, such as easily available silyl‐allyl, silyl‐enol ether, silyl‐ketene acetal, vinylogous silyl‐ketene acetal, silyl‐alkyne and silylazide reagents. Mechanistic investigations suggest that a mechanistic shift towards an intramolecular aglycone transposition involving a pentacoordinate silicon intermediate is likely responsible in steering the stereoselectivity.
Plasma‐Driven Efficient Conversion of CO2 and H2O into Pure Syngas with Controllable Wide H2/CO Ratios over Metal–Organic Frameworks Featuring In Situ Evolved Ligand Defects
Authors: Han Yali , Fan Guilan , Guo Yan , Guo Shoujun , Ding Junfang , Han Chenhui , Gao Yuliang , Zhang Jiangwei , Gu Xiaojun , Wu Limin 
Published: April 2024

AbstractWhile the mild production of syngas (a mixture of H2 and CO) from CO2 and H2O is a promising alternative to the coal‐based chemical engineering technologies, the inert nature of CO2 molecules, unfavorable splitting pathways of H2O and unsatisfactory catalysts lead to the challenge in the difficult integration of high CO2 conversion efficiency with produced syngas with controllable H2/CO ratios in a wide range. Herein, we report an efficient plasma‐driven catalytic system for mild production of pure syngas over porous metal–organic framework (MOF) catalysts with rich confined H2O molecules, where their syngas production capacity is regulated by the in situ evolved ligand defects and the plasma‐activated intermediate species of CO2 molecules. Specially, the Cu‐based catalyst system achieves 61.9 % of CO2 conversion and the production of pure syngas with wide H2/CO ratios of 0.05 : 1–4.3 : 1. As revealed by the experimental and theoretical calculation results, the in situ dynamic structure evolution of Cu‐containing MOF catalysts favors the generation of coordinatively unsaturated metal active sites with optimized geometric and electronic characteristics, the adsorption of reactants, and the reduced energy barriers of syngas‐production potential‐determining steps of the hydrogenation of CO2 to *COOH and the protonation of H2O to *H.
Degumming and bleaching process troubleshooting in a palm oil refining process using fuzzy expert system with thematic analysis
Authors: Ali Nur Syuhada Mohd , Salleh Intan Suhairi , Sulaiman Nurul Sulaiha , Malim‐Busu Tengku Zulaikha , Jamaluddin Hishamuddin , Othman Mohd Fauzi , Abdullah Shahrum Shah , Mohd‐Yusof Khairiyah 
Published: April 2024

AbstractDegumming and bleaching are critical steps in the palm oil refining process, as they are the precursors to the qualities of refined, bleached, and deodorized palm oil. In practice, plant operators often face oil rejections in these processes and solve the problem by trial and error. Hence, a fuzzy expert system is developed to troubleshoot the degumming and bleaching process, for identifying failures and suggesting actions. However, developing the knowledge base and inference engine in the fuzzy expert system for troubleshooting the degumming and bleaching process is challenging because the data in the actual palm oil refining process are poorly documented and must be obtained from various sources, including field observation, document analysis, and interviews, and need to be analyzed using thematic analysis. The results from the thematic analysis were represented as input and output variables of the fuzzy expert system. The developed fuzzy expert system is tested and validated against different data sets and industrial data to identify faults and suggest necessary actions. To evaluate the robustness of the troubleshooting system, the membership functions of the fuzzy expert system are adjusted based on the distributed control system (DCS). The results show that the troubleshooting system can effectively diagnose potential faults and provide necessary actions and can serve as a useful guidance for failures in the degumming and bleaching process.
Hepatic arterial infusion chemotherapy, lenvatinib plus programmed cell death protein‐1 inhibitors: A promising treatment approach for high‐burden hepatocellular carcinoma
Authors: Fu Shumin , Xu Yongkang , Mao Ye , He Mengting , Chen Zhimeng , Huang Shenglan , Li Dan , Lv Yaqin , Wu Jianbing 
Published: April 2024

AbstractBackgroundHepatic arterial infusion chemotherapy (HAIC) has demonstrated remarkable local therapeutic efficacy in treating patients with large unresectable hepatocellular carcinoma (HCC). Additionally, the combination of lenvatinib and programmed cell death protein‐1 (PD‐1) inhibitors has demonstrated promising antitumor effects in unresectable HCC. Therefore, we conducted a retrospective analysis to evaluate the efficacy and safety of combining HAIC with lenvatinib and PD‐1 inhibitors as a first‐line therapeutic approach in high‐burden HCC patients.MethodsWe conducted a retrospective analysis on patients diagnosed with high‐burden HCC who had major portal vein tumor thrombosis (Vp3 and Vp4) or tumor occupancy exceeding 50% of the liver. These patients received a first‐line treatment consisting of HAIC with a combination of 5‐fluorouracil, leucovorin, and oxaliplatin (FOLFOX), along with lenvatinib and PD‐1 inhibitors between November 2020 and June 2023. The primary endpoints of this study included progression‐free survival (PFS) and overall survival (OS), while the secondary endpoints were objective response rate (ORR), disease control rate (DCR), and treatment‐related adverse events (TRAEs).ResultsNinety‐one patients were enrolled in this study, with a median PFS of 8.8 months (95% confidence interval [CI]: 5.75–11.78) and a median OS of 14.3 months (95% CI: 11.23–17.31). According to RECIST 1.1 criteria, the ORR was 52.7%, and DCR was 95.6%. According to the mRECIST criteria, the ORR was 72.5%, and the DCR was 96.5%. Among all patients, 86 (94.5%) experienced TRAEs, and there were no instances of treatment‐related deaths.ConclusionThe combination of HAIC‐FOLFOX with lenvatinib and PD‐1 inhibitors as a first‐line therapy has exhibited notable therapeutic efficacy and well‐tolerated adverse events among patients with high‐burden HCC.
DFMO inhibition of neuroblastoma tumorigenesis
Authors: Gandra Divya , Mulama David H. , Foureau David M. , McKinney Kimberly Q. , Kim Elizabeth , Smith Kaitlyn , Haw Jason , Nagulapally Abhinav , Saulnier Sholler Giselle L. 
Published: April 2024

AbstractBackgroundMost high‐risk neuroblastoma patients who relapse succumb to disease despite the existing therapy. We recently reported increased event‐free and overall survival in neuroblastoma patients receiving difluoromethylornithine (DFMO) during maintenance therapy. The effect of DFMO on cellular processes associated with neuroblastoma tumorigenesis needs further elucidation. Previous studies have shown cytotoxicity with IC50 values >5–15 mM, these doses are physiologically unattainable in patients, prompting further mechanistic studies at therapeutic doses.MethodsWe characterized the effect of DFMO on cell viability, cell cycle, apoptosis, neurosphere formation, and protein expression in vitro using five established neuroblastoma cell lines (BE2C, CHLA‐90, SHSY5Y, SMS‐KCNR, and NGP) at clinically relevant doses of 0, 50, 100, 500, 1000, and 2500 μM. Limiting Dilution studies of tumor formation in murine models were performed. Statistical analysis was done using GraphPad and the level of significance set at p = 0.05.ResultsThere was not a significant loss of cell viability or gain of apoptotic activity in the in vitro assays (p > 0.05). DFMO treatment initiated G1 to S phase cell cycle arrest. There was a dose‐dependent decrease in frequency and size of neurospheres and a dose‐dependent increase in beta‐galactosidase activity in all cell lines. Tumor formation was decreased in xenografts both with DFMO‐pretreated cells and in mice treated with DFMO.ConclusionDFMO treatment is cytostatic at physiologically relevant doses and inhibits tumor initiation and progression in mice. This study suggests that DFMO, inhibits neuroblastoma by targeting cellular processes integral to neuroblastoma tumorigenesis at clinically relevant doses.
Cancer risks related to intellectual disabilities: A systematic review
Authors: Banda Amina , Naaldenberg Jenneken , Timen Aura , van Eeghen Agnies , Leusink Geraline , Cuypers Maarten 
Published: April 2024

AbstractBackgroundPeople with intellectual disabilities (ID) face barriers in cancer care contributing to poorer oncological outcomes. Yet, understanding cancer risks in the ID population remains incomplete.AimTo provide an overview of cancer incidence and cancer risk assessments in the entire ID population as well as within ID‐related disorders.MethodsThis systematic review examined cancer risk in the entire ID population and ID‐related disorders. We systematically searched PubMed (MEDLINE) and EMBASE for literature from January 1, 2000 to July 15, 2022 using a search strategy combining terms related to cancer, incidence, and ID.ResultsWe found 55 articles assessing cancer risks in the ID population at large groups or in subgroups with ID‐related syndromes, indicating that overall cancer risk in the ID population is lower or comparable with that of the general population, while specific disorders (e.g., Down's syndrome) and certain genetic mutations may elevate the risk for particular cancers.DiscussionThe heterogeneity within the ID population challenges precise cancer risk assessment at the population level. Nonetheless, within certain subgroups, such as individuals with specific ID‐related disorders or certain genetic mutations, a more distinct pattern of varying cancer risks compared to the general population becomes apparent.ConclusionMore awareness, and personalized approach in cancer screening within the ID population is necessary.
Environmental, social, and governance performance as an influencing factor of financial sustainability: Evidence from the global high‐tech sector
Authors: Nazir Marina , Akbar Minhas , Yu Xiaohong , Hussain Ammar , Svobodová Libuše 
Published: April 2024

AbstractThe corporate sector strives to improve its environmental, social, and governance (ESG) performance to transition from short‐term to sustainable long‐term profit maximisation. This study thus explores the impact of ESG performance on the financial sustainability (FS) of a sample of the top 100 global high‐tech firms. Specifically, we employ the two‐step generalised method of moments to control for endogeneity bias and a panel data fixed effects model to control for unobserved heterogeneity. Empirical findings reveal that overall ESG performance has a statistically negative association with the FS of global high‐tech firms. Individual pillar‐wise analysis reveals that the environmental and social (governance) pillar has a negative (positive) association with the FS of the sampled firms. This result proves that each ESG pillar exerts varying effects on corporate performance indicators. Overall, the results provide empirical evidence that could help policymakers devise policies for investing optimally in ESG indicators to spur corporate FS.