bluuebunny/crossref_metadata_2025_split huggingface dataset:
The impact of dynamic pricing on restaurant customers’ perceptions and price sentiment
Authors: Gómez-Talal Ismael , Talón-Ballestero Pilar , Leoni Veronica , González-Serrano Lydia 
Published: June 2024

Purpose
This study aims to examine how dynamic pricing impacts customer perceptions of restaurants and sentiment toward prices via online reputation metrics. In addition, to deepen the debate on dynamic pricing, a novel definition is drawn by exploring the specific forms of discrimination that can manifest in different industries.

Design/methodology/approach
Leveraging a comprehensive data set of restaurant reviews sourced from TripAdvisor, the study focuses on restaurants affiliated with one of the largest groups of restaurants in Spain. We used a quasi-experimental method (difference-in-differences), to study how dynamic pricing strategies influence customers’ perceptions of value based on numerical ratings. Meanwhile, we used a Bidirectional Encoder Representations from Transformers model on the textual component of reviews to dissect the emotional nuances of dynamic pricing.

Findings
Results did not reveal a causal impact of dynamic pricing strategies on customers’ perceptions. Moreover, the sentiment analysis shows no heightened negative view after introducing dynamic pricing in restaurants compared to the control group. Contrary to what previous literature suggests, our findings indicate that implementing dynamic pricing does not adversely affect customers’ perceptions or sentiments regarding prices in restaurants.

Research limitations/implications
The quasi-experimental setting of the study presents inherent challenges in establishing causality that require further investigation using controlled experimental settings. Nevertheless, our study reveals that restaurant customers do not perceive dynamic pricing as unfair. This finding is critical for restaurant managers when considering the implementation of dynamic pricing and revenue management strategies. In addition, our study highlights the importance of considering not only numerical ratings but customer sentiment analysis as well. This more holistic approach to assessing the impact of pricing strategies can give restaurant managers a deeper understanding of customer reactions. In addition, a more rigorous definition of dynamic pricing is provided, clarifying its nature and its distinction in using different price discrimination.

Originality/value
This study contributes to the evolving understanding of dynamic pricing strategies’ impact on customers’ perceptions and sentiments in the restaurant industry. It aims to fill the gap in understanding customer reactions to algorithmically determined prices (via revenue management systems such as DynamEat) in this industry. The combination of causal inference and sentiment analysis offers a novel perspective, shedding light on the nuanced connections between dynamic pricing implementation and customers’ emotions.
Exploring the impact of red mud on the mechanical, durability, and microstructure properties of concrete
Authors: Pawar Prathamesh , Patil Sudhir , Sathe Sandeep 
Published: June 2024

Purpose
This study investigated the potential of partially replacing cement with red mud (RM) in concrete and examined its effects on its mechanical properties and microstructure. This study aims to explore sustainable alternatives to traditional cement and evaluate the performance of concrete mixtures with varying percentages (%) of RM as cement replacement.

Design/methodology/approach
This research aims to comprehensively understand the impact of RM on concrete, aiming for both environmental sustainability and improved construction materials. Subsequently, concrete mixtures were prepared with varying RM contents, ranging from 0% to 21% in increments of 3%, replacing cement. The workability of these mixtures was evaluated using the Slump Cone Test, whereas their mechanical properties (compressive strength, flexural strength and split tensile strength) were assessed through standardized tests. The durability was further investigated via water absorption, acid attack, rapid chloride permeability tests, open porosity test and Sorptivity test. To gain deeper insights into the internal structure of concrete, microstructure analysis was conducted using X-ray diffraction and scanning electron microscopy. Finally, the results were analyzed and quantified.

Findings
The finding demonstrates that substituting 12% of cement with RM not only boosts the mechanical characteristics of concrete but also mitigates waste disposal. The microstructural analysis identified a denser cement matrix and improved bonding between the cement paste and the aggregates, suggesting potential improvements in strength and durability.

Originality/value
These results suggest that RM can be efficiently used to produce sustainable concrete with potential applications in construction projects with environmental considerations.
‘When all you have is a hammer, everything has to be a nail’: Managing diagnostic uncertainty in urinary tract infection
Authors: Kashouris Eleanor 
Published: June 2024

AbstractDiagnosis of urinary tract infections (UTI) is a routine part of medical work and yet is well recognised to be an area of high clinical uncertainty. Meanwhile, diagnosis of UTI is becoming increasingly important to policymakers globally due to concerns about antibiotic over‐prescription. Drawing on Mol’s concept of ontological multiplicity in clinical work, I explore how diagnostic uncertainty is co‐ordinated into certainty by a UK national diagnostic algorithm for UTI. The diagnosis of UTI is produced or withheld as a post hoc rationalisation of a prior decision whether to prescribe antibiotics or not. Work in the sociology of diagnosis has already noted that diagnostic steps are often re‐ordered by health‐care professionals taking diverse actions in the best interest of their patients. This article contributes an argument that ordering diagnostic work around antimicrobial stewardship agendas has the effect of narrowing possible actions. Exploring the consequences and effects of doing diagnosis in this way for different groups, I argue that a greater creativity about what could be done to care for painful bladders could be found in a return to more clinical ways of working.
Institutional vulnerability to urban flood risk management: A case study of the 7·20 flooding disaster in Zhengzhou, China
Authors: Shi Chunyu , Xie Chengyuan 
Published: June 2024

AbstractThe ‘vulnerability’ approach highlights institutional factors as the primary drivers of flooding risk. However, the intricate connections between institutional vulnerability and urban flood disaster risk have not been extensively explored until now. This study aims to address this gap by examining the case of the 7·20 heavy rainfall disaster in Zhengzhou. Employing a hybrid analysis methodology that integrates text coding, fault tree analysis and analytic hierarchy process methods, the study seeks to identify and assess the distinct contributions of various institutional factors and their interplay, culminating in ineffective urban flood risk management. In contrast to previous research findings that emphasize the determinant role of policy‐making and organizational coordination, this study demonstrates that inadequate legislative compliance constitutes the root cause determining the ineffectiveness of urban flood risk management. It is further exacerbated by insufficient policy attention, resulting in inadequate allocation of resources that ensure the legislative quality, risk coping skills and knowledge and stakeholders' coordination and collaboration. By emphasizing the significance of legislative compliance and policy attention, the study offers a fresh conceptual perspective to understand the factors influencing the efficiency of urban flood risk management. It provides valuable insights to develop targeted countermeasures for mitigating similar urban flood risks in the future.
Chinese exclusion? Agent response in the market for owner‐occupied housing
Authors: Hanson Andrew , Hawley Zackary 
Published: June 2024

AbstractWe design and implement a correspondence experiment to test for differences in real estate agent response to Chinese clients. In the full sample, real estate agents are no more likely to respond to white clients than Chinese clients. Subsample results show statistically significant differential treatment of Chinese clients in rural areas and in some states. White real estate agents favor white clients (7.90% higher response rate), and Chinese real estate agents favor Chinese clients by a wide margin (151.11% higher response rate).
The frailty in older hemodialysis patients and associations with depression, functional status, dialysis adequacy
Authors: Bulbul Elif , Namoglu Selda Selimoglu 
Published: June 2024

AbstractIntroductionThe aim of this study was to determine the level of frailty in older hemodialysis patients and to examine the relationship between their functional capacity, depression, and laboratory variables.MethodThis was a cross‐sectional study, and the data were collected 243 dialysis patients aged 65 and over between May 2021 and May 2022.ResultsThe frailty rate was 49%. A statistically significant positive correlation was found between the frailty and age, hemodialysis vintage, and the number of hospitalizations. The frailty was negatively correlated with body mass index, Kt/V, Albumin, and parathyroid hormone. There was a statistically significant positive correlation between frailty and depression and a negative correlation between functional capacity.ConclusionA relationship was found between frailty and depression, functional capacity, and laboratory variables. In addition, the variables affecting the level of frailty in geriatric dialysis patients included dialysis vintage, dialysis adequacy, number of hospitalizations, albumin level, and patient weight.
Risk factors for severe immune‐related pneumonitis after nivolumab plus ipilimumab therapy for non‐small cell lung cancer
Authors: Sumi Toshiyuki , Sekikawa Motoki , Koshino Yuta , Nagayama Daiki , Nagahisa Yuta , Matsuura Keigo , Shijubou Naoki , Kamada Koki , Suzuki Keito , Ikeda Takumi , Michimata Haruhiko , Watanabe Hiroki , Yamada Yuichi , Osuda Koichi , Tanaka Yusuke , Chiba Hirofumi 
Published: June 2024

AbstractBackgroundThe efficacy of anti‐CTLA‐4 antibody (ipilimumab) plus anti‐programmed cell death 1 antibody (nivolumab) in treating advanced non‐small cell lung cancer (NSCLC) is impeded by an elevated risk of severe immune‐related adverse events. However, our understanding of associations among pre‐existing fibrosis, emphysematous changes, and objective indicators as predictive factors is limited for severe pneumonitis in NSCLC patients receiving this combination therapy. Thus, we retrospectively investigated these associations, including overall tumor burden, before treatment initiation in the Japanese population.MethodsWe focused on patients (n = 76) with pre‐existing interstitial lung disease (ILD) to identify predictors of severe pneumonitis. Variables included age, sex, smoking status, programmed cell death ligand 1 expression, overall tumor burden, chest computed tomography‐confirmed fibrosis, serum markers, and respiratory function test results.ResultsSevere pneumonitis was more frequent in patients with squamous cell carcinoma, fibrosis, low diffusing capacity for carbon monoxide (%DLCO), and high surfactant protein D (SP‐D) level. Notably, squamous cell carcinoma, baseline %DLCO, and SP‐D level were significant risk factors. Our findings revealed the nonsignificance of tumor burden (≥85 mm) in predicting severe pneumonitis, emphasizing the importance of pre‐existing ILD. Conversely, in cases without pre‐existing fibrosis, severe pneumonitis was not associated with %DLCO or SP‐D level (93.2% vs. 91.9%, and 63.3 vs. 40.9 ng/mL, respectively) and was more common in patients with a large overall tumor burden (97.5 vs. 70.0 mm).ConclusionVigilant monitoring and early intervention are crucial for patients with squamous cell carcinoma, high SP‐D level, or low %DLCO undergoing ipilimumab plus nivolumab therapy.
Mapping the unicellular transcriptome of the ascending thoracic aorta to changes in mechanosensing and mechanoadaptation during aging
Authors: Rivera Cristobal F. , Farra Yasmeen M. , Silvestro Michele , Medvedovsky Steven , Matz Jacqueline , Pratama Muhammad Yogi , Vlahos John , Ramkhelawon Bhama , Bellini Chiara 
Published: June 2024

AbstractAortic stiffening is an inevitable manifestation of chronological aging, yet the mechano‐molecular programs that orchestrate region‐ and layer‐specific adaptations along the length and through the wall of the aorta are incompletely defined. Here, we show that the decline in passive cyclic distensibility is more pronounced in the ascending thoracic aorta (ATA) compared to distal segments of the aorta and that collagen content increases in both the medial and adventitial compartments of the ATA during aging. The single‐cell RNA sequencing of aged ATA tissues reveals altered cellular senescence, remodeling, and inflammatory responses accompanied by enrichment of T‐lymphocytes and rarefaction of vascular smooth muscle cells, compared to young samples. T lymphocyte clusters accumulate in the adventitia, while the activation of mechanosensitive Piezo‐1 enhances vasoconstriction and contributes to the overall functional decline of ATA tissues. These results portray the immuno‐mechanical aging of the ATA as a process that culminates in a stiffer conduit permissive to the accrual of multi‐gerogenic signals priming to disease development.
A drug–drug interaction study and physiologically based pharmacokinetic modelling to assess the effect of an oral 5‐lipoxygenase activating protein inhibitor on the pharmacokinetics of oral midazolam
Authors: Knöchel Jane , Panduga Vijender , Nelander Karin , Heijer Maria , Lindstedt Eva‐Lotte , Ali Hodan , Aurell Malin , Ödesjö Helena , Forte Pablo , Connolly Kat , Ericsson Hans , MacPhee Iain 
Published: June 2024

AimsEarly clinical studies have indicated that the pharmacokinetics of Atuliflapon (AZD5718) are time and dose dependent. The reason(s) for these findings is(are) not fully understood, but pre‐clinical profiling suggests that time‐dependent CYP3A4 inhibition cannot be excluded. In clinical practice, Atuliflapon will be co‐administered with CYP3A4 substrates; thus, it is important to determine the impact of Atuliflapon on the pharmacokinetics (PK) of CYP3A4 substrates. The aim of this study was to evaluate the effect of Atuliflapon on the pharmacokinetics of a sensitive CYP3A4 substrate, midazolam, and to explore if the time‐/dose‐dependent effect seen after repeated dosing could be an effect of change in CYP3A4 activity.MethodsOpen‐label, fixed‐sequence study in healthy volunteers to assess the PK of midazolam alone and in combination with Atuliflapon. Fourteen healthy male subjects received single oral dose of midazolam 2 mg on days 1 and 7 and single oral doses of Atuliflapon (125 mg) from days 2 to 7. A physiologically based pharmacokinetic (PBPK) model was developed to assess this drug–drug interaction.ResultsMean midazolam values of maximum plasma concentration (Cmax) and area under the curve (AUC) to infinity were increased by 39% and 56%, respectively, when co‐administered with Atuliflapon vs. midazolam alone. The PBPK model predicted a 27% and 44% increase in AUC and a 23% and 35% increase in Cmax of midazolam following its co‐administrations with two predicted therapeutically relevant doses of Atuliflapon.ConclusionsAtuliflapon is a weak inhibitor of CYP3A4; this was confirmed by the validated PBPK model. This weak inhibition is predicted to have a minor PK effect on CYP3A4 metabolized drugs.
The alleviatory effects of koumine on MSU‐induced gouty arthritis via the TLR4/NF‐κB/NLRP3 pathway
Authors: Lin Shi‐kang , Chen Shi‐ting , Zhan Ying , Guo Xin‐yue , Wu Wen‐tao , Lin Yi‐ting , Yu Chang‐xi , Yang Jian 
Published: June 2024

AbstractThe aim of this study was to validate the preventive effects of koumine (KM), a monoterpene indole alkaloid, on gouty arthritis (GA) and to explore its possible mechanisms. C57BL/6 mice were intraperitoneally administered KM (0.8, 2.4 or 7.2 mg/kg), colchicine (3.0 mg/kg) or sterile saline. One hour later, a monosodium urate (MSU) suspension was injected into the right hind paws of the mice to establish an acute gout model. Inflammation symptoms were evaluated at 0, 3, 6, 12 and 24 h, and the mechanical withdrawal threshold was evaluated at 0, 6 and 24 h. After 24 h, the mice were euthanized, and the joint tissue, kidney and blood were collected for subsequent experiments. Histological examination and antioxidant enzyme, kidney index and serum uric acid (UA) measurements were taken. The expression levels of the signalling pathway components were determined. KM effectively alleviated the symptoms of redness, swelling and pain; counteracted inflammatory cell infiltration; and increased antioxidant enzyme levels, reduced kidney index and serum UA levels through regulating UA excretion in MSU‐induced mice. The expression of toll‐like receptor 4 (TLR4)/nuclear factor kappa‐B (NF‐κB)/nucleotide‐binding oligomerization domain, leucine‐rich repeat and pyrin domain‐containing 3 (NLRP3) signalling pathway proteins and mRNA were reduced in the KM group. These results suggest that KM may be effective in alleviating GA through the TLR4/NF‐κB/NLRP3 pathway.
q‐Space Myelin Map: A new myelin‐specific imaging technique for treatment monitoring of multiple sclerosis
Authors: Kitagawa Satoshi , Kufukihara Kenji , Motegi Haruhiko , Sekiguchi Koji , Sato Yayoi , Nakahara Jin 
Published: June 2024

AbstractObjectivesIn multiple sclerosis (MS) patients, hyperintense signals on T2‐weighted images by magnetic resonance imaging are signs of demyelination; however, T2 signals lack specificity and fail to detect remyelination. For more precise monitoring of MS, a new magnetic resonance imaging technique, q‐space Myelin Map (qMM), which specifically identifies myelin, has been developed. This study aimed to explore clinical factors associated with remyelination for different disease‐modifying drugs, and to examine the utility and feasibility of qMM in clinical practice.MethodsData from sequential patients with relapsing–remitting MS initiating disease‐modifying drugs at our center were collected. After treatment initiation, qMM was carried out at 6‐month intervals and the resulting images analyzed for evidence of remyelination.ResultsA total of 48 patients with relapsing–remitting MS were included: 22 with dimethyl fumarate, 14 with fingolimod, four with glatiramer acetate and eight with natalizumab. qMM showed qMM‐remyelination in 22 patients (45.8%). In natalizumab patients, baseline ages were 33.6 ± 6.9 years (n = 5) and 47.3 ± 5.8 years (n = 3) in patients with or without qMM remyelination, respectively. In dimethyl fumarate patients, the proportion of women was 100% (n = 10) and 50% (n = 12) in patients with or without qMM myelination, respectively.ConclusionsThis exploratory study suggested the potential clinical utility of qMM for visualizing remyelination in MS patients and fine‐tuning their pharmacotherapy. Two potential clinical factors promoting qMM‐remyelination were identified: female sex with dimethyl fumarate and younger baseline age with natalizumab; a larger prospective study is warranted to confirm these results.
SIRT1 mediates the excitability of spinal CaMKIIα‐positive neurons and participates in neuropathic pain by controlling Nav1.3
Authors: Wang Yuanzeng , Zhang Yidan , Ma Nan , Zhao Wen , Ren Xiuhua , Sun Yanyan , Zang Weidong , Cao Jing 
Published: June 2024

AbstractAimsNeuropathic pain is a common chronic pain disorder, which is largely attributed to spinal central sensitization. Calcium/calmodulin‐dependent protein kinase II alpha (CaMKIIα) activation in the spinal dorsal horn (SDH) is a major contributor to spinal sensitization. However, the exact way that CaMKIIα‐positive (CaMKIIα+) neurons in the SDH induce neuropathic pain is still unclear. This study aimed to explore the role of spinal CaMKIIα+ neurons in neuropathic pain caused by chronic constriction injury (CCI) and investigate the potential epigenetic mechanisms involved in CaMKIIα+ neuron activation.MethodsCCI‐induced neuropathic pain mice model, Sirt1loxP/loxP mice, and chemogenetic virus were used to investigate whether the activation of spinal CaMKIIα+ neurons is involved in neuropathic pain and its involved mechanism. Transcriptome sequence, western blotting, qRT‐PCR, and immunofluorescence analysis were performed to assay the expression of related molecules and activation of neurons. Co‐immunoprecipitation was used to observe the binding relationship of protein. Chromatin immunoprecipitation (ChIP)‐PCR was applied to analyze the acetylation of histone H3 in the Scn3a promoter region.ResultsThe expression of sodium channel Nav1.3 was increased and the expression of SIRT1 was decreased in the spinal CaMKIIα+ neurons of CCI mice. CaMKIIα neurons became overactive after CCI, and inhibiting their activation relieved CCI‐induced pain. Overexpression of SIRT1 reversed the increase of Nav1.3 and alleviated pain, while knockdown of SIRT1 or overexpression of Nav1.3 promoted CaMKIIα+ neuron activation and induced pain. By knocking down spinal SIRT1, the acetylation of histone H3 in the Scn3a (encoding Nav1.3) promoter region was increased, leading to an increased expression of Nav1.3.ConclusionThe findings suggest that an aberrant reduction of spinal SIRT1 after nerve injury epigenetically increases Nav1.3, subsequently activating CaMKIIα+ neurons and causing neuropathic pain.
Differential associations of risk factors with severe and non‐severe hypoglycaemia: the Hypoglycaemia Assessment Tool prospective observational study in people with insulin‐treated type 1 diabetes and type 2 diabetes
Authors: He Ying , Kunutsor Setor K. , Kingsnorth Andrew P. , Gillies Clare , Choudhary Pratik , Khunti Kamlesh , Zaccardi Francesco 
Published: June 2024

AbstractAimTo assess the differential association of risk factors with severe and non‐severe hypoglycaemia.Materials and MethodsThe Hypoglycaemia Assessment Tool study evaluated the risk of hypoglycaemia over a 4‐week period in patients with type 1 diabetes (T1D) and type 2 diabetes (T2D) on insulin in 24 countries. Negative binomial regressions were applied to examine the associations of several risk factors with severe and non‐severe hypoglycaemia.ResultsThe median age was 41 years in 5949 patients with T1D and 62 years in 12 914 patients with T2D. The 4‐week rates of non‐severe hypoglycaemic were 5.57 and 1.40 episodes per person in T1D and T2D, respectively; the corresponding rates for severe hypoglycaemia were 0.94 and 0.30. The excess risk was 42% higher for severe than non‐severe hypoglycaemia in females versus males with T2D; 27% higher in patients with T2D with versus without a continuous glucose monitoring (CGM); and 47% lower in patients with T1D with versus without an insulin pump. The excess risk also differed across geographical areas and was marginally lower for severe than non‐severe hypoglycaemia for higher values of HbA1c in patients with T2D. Associations with severity of hypoglycaemia were not different for age, diabetes and insulin therapy duration, previous hypoglycaemic episodes and insulin regimen.ConclusionsThe risk of severe versus non‐severe hypoglycaemia differs in patients with T1D and T2D; sex, the use of a CGM and insulin pump, and geographical areas were differently associated with one type of hypoglycaemia than the other.