bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association between geriatric nutritional risk index and overactive bladder in the elderly population: a cross-sectional study
Authors: Zheng Wei , Zhou Chuanzan , Miao Jia , Yang Yunkai , Hu Xuanhan , Wang Heng , Zhang Xinyu , Zhang Qi , Wang Yifan 
Published: February 2025

BackgroundThe prevalence of overactive bladder (OAB) is increasing in the elderly population and there is growing evidence that malnutrition affects the urinary system. Despite this, research on the relationship between nutritional factors and OAB remains limited.MethodsWe included 17,161 elderly individuals from the National Health and Nutrition Examination Survey conducted between 2005 and 2018. Overactive Bladder Symptom Scores (OABSS) were utilized to assess symptoms of OAB. A multifactorial logistic regression analysis was employed to evaluate the independent association between the Geriatric Nutritional Risk Index (GNRI) and the prevalence of OAB. Restricted cubic spline plots examined the potential non-linear relationship between GNRI and OAB. Influencing factors were assessed through subgroup analyses, while the predictive utility of GNRI was assessed with receiver operating characteristic (ROC) curves. The influence of inflammatory response and cognitive function on the interaction between GNRI and OAB was also examined by mediation analysis.ResultsGNRI in the OAB group was significantly lower than that in the non-OAB group. Multifactorial logistic regression analysis revealed that GNRI significantly predicts OAB (p &lt; 0.05). The Restricted Cubic Spline (RCS) curve indicated a non-linear negative correlation between GNRI and the risk of OAB in the elderly (non-linear p = 0.0029). In receiver operating characteristic analysis, GNRI outperforms serum albumin or body mass index (BMI) alone in predicting OAB risk. The study revealed that inflammatory response mediates the relationship between GNRI and OAB, while cognitive function has a relatively weaker influence on the strength of the association between GNRI and OAB.ConclusionGNRI serves as a reliable predictive marker for OAB in the elderly population, demonstrating a nonlinear inverse correlation with OAB prevalence. Furthermore, this study elucidates the underlying inflammatory mechanisms that link GNRI to the development of OAB.
Diagnosis and treatment of thyroblastoma: a case report and review of literature
Authors: Chen Xiting , Xiong Lijuan , Liu Hongling , Wang Haoqiang , Cheng Donghai , Wang Wei , He Wenyuan , Xie Bo , Zhou Juan 
Published: February 2025

Background and objectiveThe diagnosis of thyroblastoma initially identified as a thyroid malignant teratoma was subsequently classified as a distinct entity by the World Health Organization (WHO) in 2022. This classification was based on the observation that the tumor presents with independent primitive multilineage elements and is frequently associated with DICER1 hotspot mutations.The objective of this study was to explore and investigate the clinicopathologic characteristics, molecular features and treatment strategies of patients with thyroblastoma, followed by a review of the previous relevant literature.MethodsThe clinical manifestations, pathological characteristics, molecular features and treatment strategies of the initial case of thyroblastoma pathologically confirmed in China were analyzed.ResultsThe tumor was revealed to have high invasive potential, rapid disease progression, and primitive multilineage elements of pathology, including immature thyroid epithelium, spindled mesenchymal proliferations, and neuroepithelial blastema. Next-generation sequencing (NGS) confirmed the presence of germline DICER1 heterozygous pathogenic mutation at p.G1784* in patient, accompanied by the somatic hotspot mutation at p.E1813D of the RNase IIIb domain. Despite local thyroid tumor resection, the disease continued to progress rapidly. However, chemotherapy with BEP led to a reduction in the tumor. The patient’s progression-free survival (PFS) reached 15 months following the administration of BEP chemotherapy in conjunction with local radiotherapy. The patient ultimately died of cardiac arrest resulting from the progression of the cancer thrombus to the right atrium and right ventricle.ConclusionAlthough thyroblastoma has been treated as a separate entity with its distinctive morphologic and molecular characteristics, its clinicopathological features, diagnosis and treatment methods and prognosis remain poorly understood, which requires more accumulated clinical case data to provide basis for the correct diagnosis and treatment in the future.
Assessment of awareness of keratoconus and its relation to eye rubbing among Saudi Arabia population
Authors: Alqasimi Nuwayyir Abdullah , Aljohani Lujain Hatim , Ambrósio Renato , AlQahtani Bader Saad , Al Haydar Nasser Saleh , Alanazi Bdour Raja , Alfurayhan Danah Tariq , Hussain Saber Lina Sami , Alsalem Fatemah Saleh , Alqahtani Nawaf Abdullah , Vargas Jose Manuel 
Published: February 2025

BackgroundKeratoconus (KC) is a bilateral, asymmetric, progressive thinning of the cornea that causes a decrease in optical quality due to induced myopia, irregular astigmatism, and higher order aberrations. KC affects 1.38 per 1,000 individuals globally, with a higher prevalence in Asian and Middle Eastern populations. Eye rubbing has been recognized as one of the leading risk factors for KC.ObjectivesThis study aimed to assess the knowledge and awareness about KC and its relation to eye rubbing among the population of the Kingdom of Saudi Arabia.MethodsA cross-sectional study was conducted in 2024 among people residing in different regions of Saudi Arabia. Data collection was carried out using an online questionnaire consisting of 21 questions, which were divided into two sections. Prior to administering the questionnaire, informed consent was obtained, and the confidentiality of the collected data was ensured.ResultsThis survey had a total of 2,059 respondents. The majority of the participants in the study were female, and their ages ranged from 18 to 30 years. Most of the participants held a university degree or higher. In total, 44% of respondents reported having allergic disorders, while 57.6% demonstrated a lack of knowledge regarding KC. The level of KC awareness was poor among Saudi residents, with 74.8% showing insufficient awareness. The group with acceptable awareness of KC was predominantly aged between 18 and 30 years and female, with a percentage of 30.4%.ConclusionThe study revealed that Saudi citizens are not knowledgeable about KC and the risks associated with eye rubbing. Additionally, the study identified several KC risk factors, including but not limited to eye rubbing, allergies, and family history. To alleviate the burden of KC in Saudi Arabia, it is imperative to enhance public health awareness and discourage the habit of eye rubbing.
Profile of STING agonist and inhibitor research: a bibliometric analysis
Authors: Wang Xuemei , Wang Qian , Gao Yidan , Jiang Lijuan , Tang Lingli 
Published: February 2025

BackgroundSTING is a core signaling hub molecule in the innate immune system, involved in various diseases, including infectious diseases, autoimmune diseases, tumors, aging, organ fibrosis, and neurodegenerative diseases. Its activation has shown great potential in anti-tumor and anti-infective therapies, with STING agonists emerging as a promising approach in cancer immunotherapy in recent years. This study identifies research trends and potential directions in the field by collecting and analyzing relevant literature.MethodsA total of 527 publications regarding STING agonists and 107 about inhibitors were retrieved from the WOS Core Collection database. Bibliometric information was extracted with CiteSpace and VOSviewer software for visualization.ResultsIt shows that research on both STING agonists and inhibitors is burgeoning rapidly. The United States and China are leading contributors in this field. Application of STING agonists primarily focuses on cancer immunotherapy, while STING inhibitors target inflammation, particularly neuroinflammation and acute lung injury.ConclusionCurrent research emphasizes optimizing STING agonists for permeability, efficacy, and safety, with nanotechnology and lipid nanoparticles being prominent delivery techniques. Future research is expected to focus on drug development and clinical applications. This comprehensive bibliometric analysis provides clinical insights and a guide for further investigation to STING agonist/inhibitor.
The physiological responses to volume-matched high-intensity functional training protocols with varied time domains
Authors: Smith Jessica S. , Bellissimo Gabriella F. , Amorim Fabiano T. 
Published: February 2025

BackgroundHigh-intensity functional training (HIFT) is typically performed with minimal or no rest periods, including “rounds for time” (RFT) or “as many rounds or repetitions as possible” (AMRAP) design. Alternatively, some HIFT workouts can be performed with prescribed rest intervals (e.g., “every minute on the minute” [EMOM]) that may have significant effects on physiological responses.PurposeTo compare the physiological responses between two different HIFT workouts (EMOM and RFT) that were matched for total work volume (TWV).MethodsTwelve trained individuals (six males and six females) performed two HIFT protocols, EMOM and RFT. Both the EMOM and RFT included five rounds of five power cleans, eight kipping pull-ups, six dumbbell thrusters, and ten burpees performed in this order. Measurements of heart rate (HR), oxygen consumption (VO2), rating of perceived exertion (RPE) (1–10 scale), blood lactate (BLA), creatine kinase (CK), excess post-exercise oxygen consumption (EPOC), and muscle oxygen saturation (SmO2) were performed.ResultsTime domains were significantly different for the EMOM and RFT workouts (20 vs. 12 min ± 3 min, p &lt; 0.00). There were significant differences between the EMOM and RFT for HR (153 ± 19 bpm vs. 171 ± 12 bpm, p &lt; 0.01), VO2 (30.8 ± 3 mL/kg/min vs. 38.1 ± 5 mL/kg/min, p &lt; 0.00), RPE (4 ± 1 vs. 7 ± 1, p &lt; 0.00), and EPOC-AUC (3.5 ± 1.2 mL/kg/min vs. 5.0 ± 1.3 mL/kg/min, p &lt; 0.00); however, there were no significant differences in mean SmO2 (p = 0.44). An interaction effect revealed that BLA was lower for the EMOM (6.5 ± 2.7 mmol/L) than the RFT (11.2 ± 2.1 mmol/L) post-exercise (p &lt; 0.00). Conversely, there was no interaction effect for CK (p &lt; 0.16), yet a significant increase was observed from pre- to post-exercise for both the EMOM and the RFT (p &lt; 0.01).ConclusionThe RFT induced greater physiological stress than the EMOM, indicating that prescribed rest intervals significantly affect the metabolic, cardiovascular, and perceptual responses during high-intensity functional exercise. Furthermore, the RFT may provide a greater cardiorespiratory stimulus, while the EMOM may be more suitable for technique development and recovery in trained individuals.
Employees’ attitudes and work-related stress in the digital workplace: an empirical investigation
Authors: Cavicchioli Maddalena , Demaria Fabio , Nannetti Francesca , Scapolan Anna Chiara , Fabbri Tommaso 
Published: February 2025

IntroductionIn the digital era, the integration of advanced, hyper-connected technologies deeply reshaped work dynamics and organizational practices, especially through the transformation of the spatial and temporal dimensions of work. This study examines the complex relationship between digitalization and work-related stress, with a particular emphasis on the impact of both digital activities (i.e., number of actions and virtual meetings) and employees’ attitudes (i.e., job satisfaction, person-organization fit, engagement, and work-life interface) on stress levels.MethodsDrawing on data from Microsoft 365 activity records and an online survey of employees in an Italian AI firm, this study applies Factor Analysis and Generalized Additive Models to analyze the above-mentioned interactions in a highly digitalized context.ResultsFindings indicate that the time–space intensification and extension of the working experience has a significant impact in terms of increasing work-related stress when exceeding certain number of off-hours digital actions and virtual meetings. Conversely, job satisfaction, perceptions of work-life enrichment and person-organization fit represent subjective employees’ attitudes that significantly influence and reduce work-related stress in a digitalized working environment.DiscussionThis study contributes to the existing academic literature by providing a more nuanced understanding of the dual impact of work digitalization on employees’ well-being. Furthermore, our findings offer practical insights into the management of employees and their level of stress in digital work settings.
Understanding stakeholder views of the use of digital therapeutic interventions within children and young people’s mental health services
Authors: Gee Brioney , Clarke Tim , Garner Jess , Teague Bonnie , Coote Georgianna , Dunne Aoife , McGuire Rachel , Laphan Andrew , Rathee Manjul , Wilson Jon 
Published: February 2025

BackgroundProviding the growing number of children and young people seeking mental health support with timely access to care poses a significant challenge. Increased use of digital technology in the delivery of children and young people’s mental health services has been proposed as a means of increasing access to treatment.MethodsWe conducted three interrelated studies to provide multi-perspective insights into the use of digital therapeutic interventions within children and young people’s mental health services in the UK. Study 1 used semi-structured interviews and an online survey to collect the views of digital therapeutic interventions of families who self-identified as facing additional barriers to accessing mental health support (n=13). Study 2 involved eight focus groups with children and young people’s clinicians, service managers, commissioners, and policy leads (n=28), exploring participants’ views and experiences of implementing and sustaining digital therapeutic interventions. Study 3 was a consensus exercise which aimed to identify actions needed to bridge the gap between the development and use of digital therapeutic interventions for children and young people’s mental health through focus groups with parents/carers and professionals (n=17), and three Delphi-survey rounds.ResultsOur findings revealed considerable enthusiasm for the increased use of digital mental health interventions for children and young people across stakeholder groups, but also identified key barriers to their implementation. Actions perceived to facilitate more effective implementation included: a) co-producing interventions, commissioning decisions and implementation plans with children and parents/carers, b) enhancing national guidance and local leadership, c) integration of digital offers within existing clinical pathways, and d) efforts to ensure accessibility and inclusivity.DiscussionDigital therapeutic interventions offer a promising solution to the challenge of improving access to mental health support for children and young people. Strengthened guidance and leadership, sustained funding and further evidence-generation are urgently needed to enable this promise to be realised.
Somatic comorbidities and health related uncertainty among Swedish adolescents with ADHD
Authors: Lundqvist Sara , Röjås Sara , Bador Kourosh , Råstam Maria , Kerekes Nóra 
Published: February 2025

IntroductionAttention-deficit/hyperactivity disorder (ADHD) frequently exists alongside psychiatric comorbidities. The coexistence of somatic diseases and ADHD constitutes a growing field of research.MethodThis study aimed to examine the prevalence of common somatic diseases in adolescents with ADHD and compare them with those in adolescents without any psychiatric diagnoses. A cross-sectional study was conducted among a convenient sample of Swedish upper secondary school students aged 15 to 19 years. Data were collected using an electronic version of the “Mental and Somatic Health without borders” survey. In 2020, 1608 adolescents completed the survey and provided self-reports of their psychiatric and somatic diagnoses.ResultsAmong the sample of Swedish adolescents, 5.5% reported having ADHD diagnoses. These adolescents reported more somatic comorbidities than those without any psychiatric diagnosis (comparison group). The most common somatic comorbidities among those with ADHD were allergies (43.4%), asthma (24.7%), and skin diseases (16.7%), which prevalences were significantly higher than those reported by adolescents in the comparison group. However the effect sizes of these differences were negligible (allergies: p=0.002, Cramer’s V=0.08; asthma: p=0.041, Cramer’s V=0.06; skin diseases: p=0.007, Cramer’s V=0.08), raising questions about the practical implications of these findings. Allergies were significantly more common in both genders with ADHD (p=0.038, Cramer’s V=0.08 in women and p=0.038, Cramer’s V=0.09 in men). Additionally, men with ADHD showed a significant association with skin diseases (p=0.007, Cramer’s V=0.12) while women with ADHD were significantly more likely to have migraine (p=0.038, Cramer’s V=0.08). Notably, adolescents with ADHD reported significantly higher rates of uncertainty regarding the existence of diabetes, rheumatoid diseases, asthma (with negligible effect sizes), and thyroid diseases (with a small effect size) than those without any psychiatric diagnoses, suggesting heightened health related anxiety within this group.ConclusionsAdolescents with ADHD reported more somatic comorbidities and greater uncertainty about the potential presence of additional somatic conditions compared to adolescents without psychiatric diagnoses. These findings highlight the importance of addressing both health literacy and access to healthcare. By focusing on this group, we cannot only improve their ability to understand and navigate the healthcare system but also strengthen their confidence in managing their own health.
Modifiable life style factors and male reproductive health: a cross-sectional study in IVF clinic attendees in Ghana
Authors: Amoah Brodrick Yeboah , Yao Bayamina Saliah , Gborsong Cosmos , Owusu Hubert , Asare George Awuku , Yeboah Emmanuel Kwabena , Ablakwa Josephine , Hammond Georgina 
Published: February 2025

BackgroundMale infertility is a significant global public health issue, with modifiable lifestyle factors such as smoking, obesity, and psychological stress contributing to impaired semen quality and hormonal dysregulation. This study investigates the relationships between modifiable lifestyle factors, reproductive hormones, and semen quality in Ghanaian males attending an IVF clinic.MethodsA cross-sectional study was conducted with 212 male participants recruited from a fertility clinic in Ghana. Lifestyle factors were assessed using standardized questionnaires, and semen samples were analyzed following WHO guidelines. Hormonal profiles (LH, FSH, testosterone, estradiol) were measured using the enzyme-linked fluorescent assay (ELFA). Statistical analyses included Pearson's product-moment correlation and Bonferroni correction.ResultsSmoking and psychological stress were significantly associated with reduced sperm motility, viability, and concentration (p &lt; 0.05). Elevated BMI correlated negatively with sperm concentration and testosterone levels (p &lt; 0.05). Alcoholic bitters was linked to decreased semen quality, while caffeine consumption showed a positive association with progressive sperm motility.ConclusionModifiable lifestyle factors, such as smoking, psychological stress, and increased body mass index (BMI), play a crucial role in male reproductive health by adversely affecting semen parameters and hormonal balance. These findings emphasize the need for public health interventions targeting modifiable behaviors to improve fertility outcomes.
Inter-agency collaboration in building urban fire resilience in Indonesia: how do metropolitan cities address it?
Authors: Harakan Ahmad , Hilman Yusuf Adam , Karso A. Junaedi , Awaluddin Awaluddin , Nurhalijah Nurhalijah , Muin Indah Sidrawaty , B Aldy Nurdiansyah , Fadillah Arfan , Hardi Rudi 
Published: February 2025

IntroductionUrban fire disasters pose a significant challenge to city resilience and sustainability, particularly in the Global South, where rapid urbanization exacerbates existing vulnerabilities. In Indonesia, recurring fire incidents, ranging from forest fires to residential fires in densely populated areas, highlight the urgent need for effective fire disaster management. This study focuses on Makassar, a metropolitan city facing increasing fire risks due to high population density, aging infrastructure, and limited preparedness.MethodsThis research employs a qualitative approach, drawing on fire incident data from 2018 to 2023, interviews, and historical analysis to assess collaboration mechanisms in fire disaster management. The study examines inter-agency coordination, communication gaps, and resource allocation issues, which hinder effective disaster response.ResultsFindings reveal a concerning rise in fire incidents in Makassar, leading to significant socio-economic impacts, including fatalities and property damage. The study identifies critical deficiencies in inter-agency collaboration, largely due to differing organizational cultures, inadequate coordination mechanisms, and resource distribution challenges.Discussion and conclusionBy evaluating global fire resilience models, the research proposes a governance framework to enhance inter-agency cooperation in Makassar. The study advocates for integrated strategies, combining infrastructure development with community-driven initiatives to strengthen disaster prevention, response, and recovery. These findings contribute to sustainable urban development, ensuring greater resilience against fire disasters in rapidly urbanizing cities.
Can handheld ultrasound probes reliably measure transabdominal prostate and bladder volumes? A prospective randomized point-of-care ultrasound study
Authors: Wright Henry C. , Corrigan Dillon , De Smita 
Published: February 2025

BackgroundNational guidelines recommend obtaining prostate gland volume (PGV) prior to benign prostate hyperplasia (BPH) surgery. Measurement of PGV with handheld ultrasound (HUS) probes shows promise.ObjectiveTo compare the reliability of two HUS probes (Butterfly iQ and Clarius C3) to the BPH guideline-recommended imaging (GIm) for both prostate and bladder volumetrics.MethodsMale patients with GIm were randomized to undergo transabdominal HUS PGV with one of the two probes. A subset underwent voided volume measurements with one of the two HUS and a conventional bladder scanner (BS). The reliability of the volume measurements was assessed for each probe via intraclass correlation coefficients (ICCs). We utilized the following standard criteria: ICC &lt; 0.5: poor reliability; 0.5 ≤ ICC &lt; 0.75: moderate reliability; and ICC ≥ 0.75: good reliability.ResultsA total of 78 men in the prostate arm (38 Butterfly, 40 Clarius) and 45 in the bladder arm (24 Butterfly, 21 Clarius) were randomized and included in this study. The mean prostate volume based on GIm was larger in the Clarius group (p = 0.044). Other baseline characteristics were similar between groups (p &gt; 0.05). The ICCs were 0.78 (95% CI: 0.62, 0.88) and 0.71 (95% CI: 0.51, 0.83) for the Butterfly and Clarius probes, respectively. Regarding bladder volumetrics, the ICCs were 0.82 (95% CI: 0.19, 0.95), 0.72 (95% CI: 0.44, 0.88), and 0.69 (95% CI: 0.13, 0.87) for the Butterfly, Clarius, and bladder scanner, respectively.ConclusionsThe Butterfly iQ demonstrated good reliability for PGV and voided volume measurements, in comparison to moderate reliability for Clarius C3.