bluuebunny/crossref_metadata_2025_split huggingface dataset:
Integrating modern dermatology and Ayurveda in the treatment of vitiligo and lymphedema in India
Authors: Narahari Saravu R. , Ryan Terence J. , Bose Kuthaje S. , Prasanna Kodimoole S. , Aggithaya Guruprasad M. 
Published: February 2011

AbsractBackground  Globally, governments have recognized the growing popularity of Complementary and Alternative Medicines and the possibility of their combined use with biomedicine. Decisions within the Government of India have led to a conducive environment for conducting clinical studies, to achieve integration of more than one system of medicine, so that their combined benefits can be brought to bear on chronic, difficult‐to‐treat conditions.Aim  To develop integrative dermatology treatment protocols for patients with long‐standing skin diseases who have received treatment from many centers.Materials and Methods  A team of doctors from modern dermatology, Ayurveda, yoga therapy, and homeopathy studied recruited patients to develop mutual orientation on each therapeutic system and a working knowledge of approach to their clinical diagnosis. Six‐hundred thirty‐eight patients affected by lower limb lymphedema requiring skin care as a major part of treatment were treated integrating modern dermatology and Ayurveda. Three‐hundred eighty‐one vitiligo patients were examined and treated to understand the clinical presentations and treatment options in Ayurveda.Results  A two‐step cluster analysis performed by SPSS Version 16 showed average volume reductions of 13.3% and 23% on day 14, 19.7% and 31.1% on day 45, and 23.4% and 39.7% on day 90 of treatment in small and large lymphedematous limbs. Inflammatory episodes before the onset on this treatment was reported by 79.5% of our lymphedema patients, and 9.4% reported this at the end of three months after our treatment. Among vitiligo patients, we found that 39.6% of patients had kapha, 39.8%pitta, 10.8% had vatha and 0.52% has tridoshaja presentation. There are over 100 treatment options available in Ayurveda to treat vitiligo.Discussion  Each system of medicine recognizes the same disease albeit with minor difference in description. Skin care procedures like washing and emollients restore the barrier function and skin health. We have converged Ayurvedic skin care with that of dermatology with an aim of achieving patient management that is better than that achievable by a single system alone. Overload of the lymphatic system due to loss of epidermal barrier function and consequent inflammation from bacteria and soil irritants is responsive to selected Ayurvedic herbal preparations.Conclusion  It is evident that integration at the therapeutic level is possible, although the pathological basis is interpreted differently. Irrespective of background understanding of the given disease, a mutually oriented multisystem therapeutic team was able to effectively use medicines from more than one system of medicine and to develop guidelines for their prescription and a patient care algorithm.
Do physicians’ recommendations pull patients away from their preferred treatment options?
Authors: Mendel Rosmarie , Traut‐Mattausch Eva , Frey Dieter , Bühner Markus , Berthele Achim , Kissling Werner , Hamann Johannes 
Published: February 2011

AbstractContext and objective  Shared decision making is especially advocated for preference‐sensitive decisions. We investigated whether physicians’ recommendations pull patients away from their preferred treatment option when making a preference‐sensitive decision.Design, participants and methods  Inpatients (N = 102 with schizophrenia, N = 101 with multiple sclerosis) were presented with a hypothetical scenario (the choice between two drugs). They were first asked about their preferences concerning the two drugs and then they received a (fictitious) clinician’s recommendation that was contrary to their preferences. Subsequently they made a final choice between the two drugs.Main outcome measures  The main outcome measure was whether the patient followed the physician’s advice in the hypothetical scenario. Thereby patient’s (pre‐recommendation) preferences served as a baseline.Results  In the decision scenario, about 48% of the patients with schizophrenia and 26% of the patients with multiple sclerosis followed the advice of their physician and thus chose the treatment option that went against their initial preferences. Patients who followed their physician’s advice were less satisfied with their decision than patients not following their physician’s advice (schizophrenia: t = 2.61, P = 0.01; multiple sclerosis: t = 2.67, P = 0.009).Discussion and conclusions  When sharing decisions with patients, physicians should be aware that their advice might influence patients’ decisions away from their preferred treatment option. They should encourage their patients to identify their own preferences and help to find the treatment option most consistent with them.
Age‐related sensitization profiles for hazelnut (Corylus avellana) in a birch‐endemic region
Authors: De Knop K. J. , Verweij M. M. , Grimmelikhuijsen M. , Philipse E. , Hagendorens M. M. , Bridts C. H. , De Clerck L. S. , Stevens W. J. , Ebo D. G. 
Published: February 2011

To cite this article: De Knop KJ, Verweij MM, Grimmelikhuijsen M, Philipse E, Hagendorens MM, Bridts CH, De Clerck LS, Stevens WJ, Ebo DG. Age‐related sensitization profiles for hazelnut (Corylus avellana) in a birch‐endemic region. Pediatr Allergy Immunol 2011; 22: e139–e149.AbstractBackground:  Symptoms of hazelnut allergy seem related to geographic and possibly age variations in allergen recognition.Objective:  To investigate sensitization profiles of hazelnut allergy in different age groups in a birch‐endemic region using component resolved diagnosis (CRD) by microarray.Methods:  Sixty‐five patients with hazelnut allergy, 27 healthy control individuals tolerant to hazelnut, and 34 birch pollen allergic but hazelnut tolerant individuals were included. All blood samples were analyzed using ISAC microarray.Results:  Twenty‐nine patients with hazelnut allergy suffered from a systemic reaction (17 preschool children with a median age of 2 years, six school children, and six adults), whereas 36 patients reported an oral allergy syndrome (OAS; three preschool and nine school children and 24 adults). In the hazelnut allergic preschool children with systemic reactions, 65% were sensitized to Cor a 9, 12% to Cor a 8, 18% to Cor a 1.04, 6% to Cor a 1.0101, and 29% to Bet v 1. Of the school‐aged systemic reactors, 50% were sensitized to Cor a 9, 17% to Cor a 8, 50% to Cor a 1.04 and Cor a 1.0101, and 67% to Bet v 1. In adults with hazelnut allergy, 3.3% were sensitized to Cor a 9, 6.7% to Cor a 8, 90% to Cor a 1.04 and Bet v 1, and 87% to Cor a 1.0101. In regard to systemic reactors in this group, 17% were sensitized to Cor a 9, 33% to Cor a 8 and Cor a 1.0101, and 50% to Cor a 1.04 and Bet v 1. In the patients with OAS, irrespective the age group, all were sensitized to Bet v 1 and over 97% to Cor a 1.04 and Cor a 1.0101. No sensitization to Cor a 9 or Cor a 8 was found in patients with only an OAS. Of the patients with birch pollen allergy, tolerant to hazelnut, none were sensitized to Cor a 9 or Cor a 8, 56% to Cor a 1.0101, 82% to Cor a 1.04, and 92% to Bet v 1. In healthy controls, no sensitization to components of hazelnut, hazel pollen or birch pollen was demonstrable.Conclusion:  Hazelnut allergy in a birch‐endemic region exhibits age‐related sensitization profiles with distinct clinical outcomes that can be identified using CRD. The majority of hazelnut allergic preschool and school children in a birch‐endemic region show systemic reactions on consumption of processed hazelnut, mostly being sensitized to the hazelnut legumin‐like allergen Cor a 9 but unrelated to birch pollen allergy. In contrast, adults generally suffer from an OAS apparently as a result of cross‐reactivity between Cor a 1.04 from hazelnut and Bet v 1 from birch pollen.
Season of birth and childhood food allergy in Australia
Authors: Mullins Raymond James , Clark Sunday , Katelaris Constance , Smith Victoria , Solley Graham , Camargo Jr Carlos A. 
Published: February 2011

To cite this article: Mullins RJ, Clark S, Katelaris C, Smith V, Solley G, Camargo CA, Jr. Season of birth and childhood food allergy in Australia. Pediatric Allergy Immunology 2011; 22: 583–589.AbstractBackground:  Recent studies suggest a possible role for low ultraviolet radiation exposure and low vitamin D status as a risk factor for food allergy. We hypothesized that children born in autumn/winter months (less sun exposure) might have higher food allergy rates than those born in spring/summer.Methods:  We compared IgE‐mediated food allergy rates by season of birth in 835 children aged 0–4 yr assessed 1995–2009 in a specialist referral clinic, using population births as controls. To address potential concerns about generalizability, we also examined national prescriptions for adrenaline autoinjectors (2007) and infant hypoallergenic formula (2006–2007).Results:  Although live births in the general ACT population showed no seasonal pattern (50% autumn/winter vs. 50% spring/summer), autumn/winter births were more common than spring/summer births among food allergy patients (57% vs. 43%; p < 0.001). The same seasonal pattern was observed with peanut (60% vs. 40%; p < 0.001) and egg (58% vs. 42%; p = 0.003). Regional UVR intensity was correlated with relative rate of overall food allergy (β, −1.83; p = 0.05) and peanut allergy (β, −3.27; p = 0.01). National data showed that autumn/winter births also were more common among children prescribed EpiPens (54% vs. 46%; p < 0.001) and infant hypoallergenic formula (54% vs. 46%; p < 0.001).Conclusions:  The significantly higher rates of food allergy in children born autumn/winter (compared to spring/summer), the relationship between relative food allergy rates and monthly UVR, combined with national adrenaline autoinjector and infant hypoallergenic formula prescription data, suggest that ultraviolet light exposure/vitamin D status may be one of many potential factors contributing to childhood food allergy pathogenesis.
The treatment of an unusual complication associated with a HeartMate II LVAD in an adolescent
Authors: Echo Anthony , Kelley Brian P. , Bullocks Jamal M. , Morales David L. 
Published: February 2011

Echo A, Kelley BP, Bullocks JM, Morales DL. The treatment of an unusual complication associated with a HeartMate II LVAD in an adolescent.Abstract:  The HeartMate II LVAD has provided a bridge to heart transplantation or a permanent fixture for destination therapy for patients with heart failure. LVAD infections are associated with significant morbidity even when treated with explantation, device exchange, or a salvage procedure. We present an unusual complication following the placement of the HeartMate II device in an adolescent, whereby a pocket infection resulted in a large soft tissue defect overlying and surrounding the device. The novel use of a VRAM flap was successfully used to repair the defect and salvage the device.
Antigen‐binding specificity of anti‐αGal reagents determined by solid‐phase glycolipid‐binding assays. A complete lack of αGal glycolipid reactivity in α1,3GalT‐KO pig small intestine
Authors: Diswall Mette , Gustafsson Anki , Holgersson Jan , Sandrin Mauro S. , Breimer Michael E. 
Published: February 2011

Diswall M, Gustafsson A, Holgersson J, Sandrin MS, Breimer ME. Antigen‐binding specificity of anti‐αGal reagents determined by solid‐phase glycolipid‐binding assays. A complete lack of αGal glycolipid reactivity in α1,3GalT‐KO pig small intestine. Xenotransplantation 2011; 18: 28–39. © 2011 John Wiley & Sons A/S.Abstract:  Background:  αGal‐specific lectins, monoclonal and polyclonal antibodies (Abs) are widely used in xenotransplantation research. Immunological assays such as immunohistochemistry, flow cytometry, Western blot and thin layer chromatography are often the only applicable characterization procedures when limited amount of tissue is available and biochemical characterization is impossible. Hence, detailed knowledge of the Ab/lectin carbohydrate‐binding specificity is essential.Methods:  The binding specificity of human blood group AB serum, three different affinity‐purified human polyclonal anti‐Gal Ab batches, and two anti‐Gal mAb clones (TH5 and 15.101) as well as Griffonia simplicifolia isolectin B4 and Marasmius oreades agglutinin were examined for reactivity with glycolipid fractions isolated from human and pig (wild‐type and α1,3GalT‐KO) tissues using thin layer chromatogram and microtiter well binding assays.Results:  All anti‐Gal‐specific reagents reacted with the pentaglycosylceramide Galα1,3nLc4, and several 6–12 sugar compounds in wild‐type pig kidneys. However, their staining intensity with different αGal antigens varied considerably. Some, but not all, anti‐Gal reagents cross‐reacted with a pure iGb3 glycolipid reference compound. No reactivity with glycolipids isolated from α1,3GalT‐KO pig small intestine or human tissues was found, confirming the specificity of the anti‐Gal reagents in those tissues for α1,3Gal‐epitopes produced by the α1,3GalT (GGTA1).Conclusions:  Different anti‐Gal reagents vary in their carbohydrate epitope specificity. Mono‐/polyclonal Abs and lectins have different carbohydrate epitope fine specificity toward pig glycolipids as well as purified Galα1,3nLc4, and iGb3. Despite the difference in αGal specificity, all reagents were completely non‐reactive with glycolipids isolated from α1,3GalT‐KO pig small intestine.
Antioxidant Profile and Polyphenol Oxidase Activities in Apple Leaves after Erwinia amylovora Infection and Pretreatment with a Benzothiadiazole‐type Resistance Inducer (BTH)
Authors: Skłodowska Maria , Gajewska Ewa , Kuźniak Elżbieta , Wielanek Marzena , Mikiciński Artur , Sobiczewski Piotr 
Published: February 2011

AbstractThis study focused on the biochemical effects of benzo‐(1,2,3)‐thiadiazole‐7‐carbothioic acid S‐methyl ester (BTH), an active compound of the commercial preparation Bion, as an elicitor of resistance to fire blight (Erwinia amylovora) in apple. We determined activities of main antioxidant enzymes: ascorbate peroxidase (APX), catalase, glutathione peroxidase (GSH‐Px) and glutathione transferase (GST), enzymes associated with phenolic metabolism: phenylalanine ammonia‐lyase and polyphenol oxidases (PPOs), levels of low molecular antioxidants [ascorbate, glutathione, tocopherol (TOC)], phenolic acids and flavonoids as well as markers of oxidative processes: superoxide anion radical (O2·−) and thiobarbituric acid reactive substances in apple leaf tissues pretreated and non‐pretreated with BTH before inoculation with E. amylovora. The results indicate that successful invasion of pathogen might be associated with a significant decrease in the ascorbate pool in an early phase of plant–pathogen interaction. Generation of O2·− and changes in some antioxidant parameters (APX, GSH‐Px, GST, TOC) were less intensive and/or occurred earlier in the BTH‐pretreated apple leaves than in non‐pretreated ones. In the BTH‐pretreated group, PPOs activities were higher than in the control throughout the experiment, whereas in the non‐pretreated group, the increase started from the 7th day after inoculation. Infection strongly enhanced chlorogenic and o‐coumaric acids accumulation, and BTH weakened this effect. The opposite was observed with respect to phloretin and phloridzin.
Effects of Breeding at the Second Oestrus or After Post‐Weaning Hormonal Treatment with Altrenogest on Subsequent Reproductive Performance of Primiparous Sows
Authors: Werlang RF , Argenti LE , Fries HCC , Bernardi ML , Wentz I , Bortolozzo FP 
Published: February 2011

ContentsThis study investigated the effects of breeding at the second oestrus after weaning or after feeding an orally active progestagen (altrenogest) on the subsequent reproductive performance of primiparous sows. After 3 weeks of lactation, 663 weaned sows of two genotypes were allocated into three groups: G1 – breeding at the first oestrus after weaning; G2 – breeding at the second oestrus after weaning and G3 – treatment with altrenogest for 5 days after weaning and breeding at the first oestrus after the end of the treatment. Body weight at breeding was lower in G1 and G3 than in G2 sows (p < 0.05). The interval to show oestrus was similar for G1 and G2 groups (p > 0.05) but higher (p < 0.05) than that observed in G3 group. Within genotype A, percentages of females in oestrus within 10 days were not different (p > 0.05) among groups, whereas in genotype B, more G1 and G2 sows (p < 0.05) showed oestrus than G3 sows. In both genotypes, lower farrowing rates were observed in G3 than in G1 and G2 sows (p < 0.05) and a greater litter size (p < 0.05) was observed in G2 sows. In genotype A, the number of total born piglets was similar for G1 and G3 groups (p > 0.05), whereas in genotype B, G1 sows had a greater litter size than G3 sows (p < 0.05). Body weight at weaning and at breeding was similar (p > 0.05) between farrowed and non‐farrowed sows in all groups. Reproductive performance is not improved in primiparous sows treated with altrenogest during 5 days after weaning. The reproductive performance of genotype B sows is compromised in Control and Altrenogest‐treated sows but not in those bred at the second oestrus after mating. Breeding at the second oestrus after weaning allows primiparous sows to gain weight between weaning and service, and increases their farrowing rate and subsequent litter size.
Spatial and Temporal Gene Expression of Fn‐Type II and Cysteine‐Rich Secretory Proteins in the Reproductive Tracts and Ejaculated Sperm of Chinese Meishan Pigs
Authors: Song CY , Gao B , Wu H , Wang XY , Zhou HY , Wang SZ , Li BC , Chen GH , Mao JD 
Published: February 2011

ContentsFibronectin type II and cysteine‐rich secretory proteins have been well studied in the murine and human. The present study evaluated CRISP1, CRISP2, CRISP3 and Fn‐type II (ELSPBP1 and pB1) gene expression patterns in ejaculated sperm and reproductive tracts of Chinese Meishan pigs from birth to day 150 of age. In ejaculated sperm, except for ELSPBP1, all others genes studied were detectable. In sexually mature boars and gilts, CRISP1 gene was expressed strongly in whole epididymides, moderate in prostate and weak in seminal vesicle. CRISP2 gene represented extensive distribution along reproductive tracts with highest abundance in testis. CRISP3 gene was expressed highly in prostate and bulbourethral gland, but weakly in testis. ELSPBP1 gene was expressed with highest abundance in cauda epididymides, moderate in corpus epididymides and weak in seminal vesicle and prostate. pB1 mRNA expression was also abundant along reproductive tracts. During the sexual development of boars after birth, these genes showed different expression patterns. CRISP1 and CRISP3 gene expression was high on day 1 and maintained until day 150, while CRISP2 expression was detectable on day 60 with high abundance and maintained until day 90 and dropped on day 150. ELSPBP1 showed low expression at birth and increased significantly on day 30 (p < 0.05) and then kept static until day 150. pB1 gene displayed moderate expression from birth to day 30 and increased significantly on day 60 (p < 0.05) and maintained at high level until day 150. Collectively, CRISP and Fn‐type II genes were expressed extensively along genital tracts, and most of them showed mRNA signal in ejaculated sperm. The expression of CRISP1 and CRISP3 genes in Meishan boar was not age‐dependent, while CRISP2 and pB1 gene expression was parallel with sexual development. Their unique gene expression patterns may shed light on the mechanism for the high prolificacy of Meishan pigs.
Spatial–temporal distribution of ornithochorous seeds from an Elaeagnus umbellata community dominating a riparian habitat
Authors: KOHRI MARI , KAMADA MAHITO , NAKAGOSHI NOBUKAZU 
Published: February 2011

AbstractThe dispersal efficiency and potential distribution of ornithochorous seeds of Elaeagnus umbellata in a riparian habitat were evaluated to clarify this species' establishment site in relation to the disturbance regime of the floodplain. Fruit removal by avian frugivores was monitored using fruit bags, and the spatial distribution of excreted seeds was quantified by seed traps set randomly on a gravel bar as an isolated seed source in the Yoshino River throughout an autumn fruiting season. Although more than 45% of the fruits remained on the twigs in the fruit bags, almost all fruits on the control twigs without fruit bags were exploited by the beginning of January. The fruit removal rate and seed dispersal distance were positively correlated with an increase in wintering bird species and their abundance. Intact bird‐dispersed seeds of E. umbellata were trapped within a 400‐m range and damaged seeds were limited to traps set within 50 m from the seed source. Frugivore behavior, such as feces excretion on rocks near water drinking sites and perching on surrounding woodland, greatly influenced the spatial and temporal dispersal pattern of the seed rain. In the present study, the avian frugivores showed upstream seed dispersal; thus, in years with stochastic autumnal floods, secondary dispersal via hydrochory downstream may be facilitated. The intensive seed dispersal in E. umbellata indicates that the present distribution of parent trees in the restricted elevation range of the gravel bars is the result of survival through disturbance, rather than seed dispersal limitation.
Effects of salinity and temperature onex situgermination of the threatened Gulf of St. Lawrence Aster,Symphyotrichum laurentianumFernald (Nesom)
Authors: HEARD STEPHEN B. , ANCHETA JUSTIN 
Published: February 2011

AbstractThe threatened Gulf of St. Lawrence Aster,Symphyotrichum laurentianumFernald (Nesom), is an annual coastal halophyte of the southern Gulf of St. Lawrence, Canada. We examined the effects of salinity (0–20 g/L) and temperature (16–30°C) on germination ofS. laurentianumseeds over 32 days. The time‐course of germination was significantly affected by both salinity and temperature. At lower temperatures (16°C and 23°C), germination was inhibited by salt water at days 16 and 32. However, at 30°C germination rates after 16 days were highest at an intermediate salinity, whereas after 32 days germination was uniformly high in all salinity treatments. Overall, the effect of temperature on germination was much stronger than the effect of salinity. Delays in germination resulting from exposure to salinity or from low soil temperatures could set up strong size asymmetries between seedlings ofS. laurentianumand the surrounding vegetation, leading to suppression of growing seedlings via shading. Because germination has the potential to be a significant population bottleneck for this seed‐dependent annual, conservation efforts should consider microsite suitability for germination in the management of natural populations and in the selection of sites for explants.
Parental age and child growth and development: Child health check‐up data
Authors: Iwayama Mariko , Kira Ryutaro , Kinukawa Naoko , Sakai Yasunari , Torisu Hiroyuki , Sanefuji Masafumi , Ishizaki Yoshito , Nose Yoshiaki , Matsumoto Toshimichi , Hara Toshiro 
Published: February 2011

AbstractBackground:  The aim of the present study was to determine whether parental age has any influence on child health.Methods:  Well‐baby check‐up data at 1 month and at 12 months of age were used. The trends of parental age in association with growth measurements, incidence of physical and developmental abnormalities, occurrence of low birthweight, and maternal history of spontaneous abortion were analyzed.Results:  Associations between increasing paternal age and incidence of psychomotor developmental delay at 12 months, increasing paternal and maternal age and increasing birthweight, and increasing parental age and higher incidence of history of spontaneous abortion were found. The incidence of low‐birthweight infants was significantly decreased with increasing paternal age.Conclusions:  Not only increasing maternal age but also increasing paternal age have influences on child development and growth in the general population.