bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mechanisms of cerebrospinal fluid secretion by the choroid plexus epithelium: Application to various intracranial pathologies
Authors: Johnsen Laura Øllegaard , Friis Kathrine Abildskov , Møller‐Madsen Maria Kirstine , Damkier Helle Hasager 
Published: June 2024

AbstractThe choroid plexus (CP) is a small yet highly active epithelial tissue located in the ventricles of the brain. It secretes most of the CSF that envelops the brain and spinal cord. The epithelial cells of the CP have a high fluid secretion rate and differ from many other secretory epithelia in the organization of several key ion transporters. One striking difference is the luminal location of, for example, the vital Na+‐K+‐ATPase. In recent years, there has been a renewed focus on the role of ion transporters in CP secretion. Several studies have indicated that increased membrane transport activity is implicated in disorders such as hydrocephalus, idiopathic intracranial hypertension, and posthemorrhagic sequelae. The importance of the CP membrane transporters in regulating the composition of the CSF has also been a focus in research in recent years, particularly as a regulator of breathing and hemodynamic parameters such as blood pressure. This review focuses on the role of the fundamental ion transporters involved in CSF secretion and its ion composition. It gives a brief overview of the established factors and controversies concerning ion transporters, and finally discusses future perspectives related to the role of these transporters in the CP epithelium.
p‐Coumaric acid pronounced protective effect against potassium bromate‐induced hepatic damage in Swiss albino mice
Authors: Nivetha Selvaraj , Asha Kumaraswami Radha Thayammal , Srinivasan Subramani , Murali Raju , Kanagalakshmi Ambothi 
Published: June 2024

AbstractPotassium bromate (KBrO3) is a common dietary additive, pharmaceutical ingredient, and significant by‐product of water disinfection. p‐coumaric acid (PCA) is a naturally occurring nutritional polyphenolic molecule with anti‐inflammatory and antioxidant activities. The goal of the current investigation was to examine the protective effects of p‐coumaric acid against the liver damage caused by KBrO3. The five groups of animals‐control, KBrO3 (100 mg/kg bw), treatment with KBrO3 along with Silymarin (100 mg/kg bw), KBrO3, followed by PCA (100 mg/bw, and 200 mg/kg bw) were randomly assigned to the animals. Mice were slaughtered, and blood and liver tissues were taken for assessment of the serum biochemical analysis for markers of liver function (alanine transaminase, aspartate transaminase, alkaline phosphatase, albumin, and protein), lipid markers and antioxidant markers (TBARS), glutathione peroxidase [GSH‐Px], glutathione (GSH), and markers of hepatic oxidative stress (CAT), (SOD), as well as histological H&E stain, immunohistochemical stain iNOS, and COX‐2 as markers of inflammatory cytokines. PCA protects against acute liver failure by preventing the augmentation of blood biochemical markers and lipid profiles. In mice liver tissues, KBrO3 increases lipid indicators and depletes antioxidants, leading to an increase in JNK, ERK, and p38 phosphorylation. Additionally, PCA inhibited the production of pro‐inflammatory cytokines and reduced the histological alterations in KBrO3‐induced hepatotoxicity. Notably, PCA effectively mitigated KBrO3‐induced hepatic damage by obstructing the TNF‐α/NF‐kB‐mediated inflammatory process signaling system. Additionally, in KBrO3‐induced mice, PCA increased the intensities of hepatic glutathione (GSH), SOD, GSH‐Px, catalase, and GSH activities. Collectively, we demonstrate the molecular evidence that PCA eliminated cellular inflammatory conditions, mitochondrial oxidative stress, and the TNF‐α/NF‐κB signaling process, thereby preventing KBrO3‐induced hepatocyte damage.
Impact of Li Ion Transport Properties on Reversibility of Li Metal Electrode in Glyme‐Based Electrolytes
Authors: Murai Junichi , Ishikawa Toru , Wada Gakuto , Dokko Kaoru , Watanabe Masayoshi , Ueno Kazuhide 
Published: June 2024

AbstractThe demand for innovative batteries with high specific energy densities has increased. Li‐metal batteries employing Li‐metal anodes, regarded as the ultimate anodes with a high theoretical capacity, have been extensively studied over the past few decades. However, the poor reversibility and safety concerns regarding Li‐metal anodes remain unresolved. The importance of the electrode/electrolyte interface, especially the solid electrolyte interphase (SEI), for achieving reversibility of Li metal anodes has been extensively studied. Herein, we focused on the impact of the Li ion transport properties in oligoether (glyme)‐based electrolytes on the deposition/dissolution efficiency of Li metal anodes. Analysis of the low‐frequency impedance spectra of Li‐plated Cu/Li cells revealed that the diffusion resistance of Li ions (Rdiffusion) may be a dominant contributor to the internal resistance of the cells employing glyme‐based electrolytes. A higher Rdiffusion in poor‐mass‐transport electrolytes with a lower Li ion transference number resulted in larger polarization during Li deposition/dissolution, leading to more pronounced unfavorable side reactions and lower Coulombic efficiency. Rdiffusion rather than interfacial resistance affected the reversibility of the Li metal anode. Enhancing the Li ion mass transport ability of electrolytes is important for achieving highly reversible charge‐discharge performance of Li metal anodes at high current densities.
Electrochemical Behaviour and Sensing of Chlorpromazine at Polymer‐Free Kaolin‐Based Nanosodalite and Nanosodalite‐Graphene Foam Film modified Glassy Carbon Electrodes
Authors: Parfait Tchoumi Firmin , Ghislain Fotsop Cyrille , Bertrand Tamne Guy , Langmi Henrietta W. , Claude Kemmegne‐Mbouguen Justin , Ngameni Emmanuel 
Published: June 2024

AbstractA nanosodalite (SOD) was synthesized utilizing Cameroonian kaolin and then used to prepare a nanocomposite (SOD‐GF) with graphene foam (GF). The as‐synthesized materials were characterized using X‐ray diffractometry (XRD), Fourier transform‐infrared (FT‐IR) spectroscopy, N2 adsorption‐desorption and scanning electron microscopy coupled with emission dispersive X‐ray (SEM/EDX). The results show a pure sodalite with high degree of crystallinity with crystallite size and BET surface area of 38.3 nm and 22 m2/g, respectively. The composite's characterization revealed a well‐integrated material in which the structural integrity of each material is maintained, its surface area being 4‐fold that of pristine SOD. Stable SOD and SOD‐GF modified glassy carbon electrode (GCE) were prepared by drop coating without a binder and utilized to study the electrochemistry of chlorpromazine (CPZ) in acidic, neutral and basic pHs. It appeared that (i) CPZ's electrochemical oxidation was a two‐step one‐electron process at SOD/GCE and a one‐step two‐electron process at SOD‐GF/GCE and (ii) the electrochemical reaction mechanism was an EEC mechanism at SOD/GCE while at SOD‐GF/GCE the mechanism was EEC at pH<4 and EC for greater pH. SOD/GCE and SOD‐GF/GCE were used to sense CPZ within CPZ's concentration ranging from 0.5‐30 μM with low detection limits.
Enhancing Electrochemical Characteristics of Li‐Metal Electrodes: The Impact of Pre‐Treatment via CO2 Gas Reaction
Authors: Kim Yeji , Maldonado Nogales Paul , Lee Changhee , Jeong Soon‐Ki 
Published: June 2024

AbstractRegulation of the surface film characteristics of Li‐metal is a pivotal strategy for augmenting the electrochemical performance of Li‐metal batteries. This investigation elucidates a straightforward approach to surface film modification, namely, pre‐treatment via a CO2 gas reaction, and its subsequent impact on the electrochemical attributes of Li‐metal electrodes. Analysis of the topography and composition of the Li metal surfaces revealed the transformation of the surface film into a more uniform layer enriched with inorganic compounds, including Li2CO3 and Li2O, by pre‐treatment. This pre‐treatment process significantly enhances the electrochemical properties, such as cyclability and overpotential, in Li/Li symmetric cells, primarily because of the formation of an improved solid‐electrolyte interphase (SEI) derived from the altered surface film on Li metal electrodes. The reformed SEI significantly increases the mobility of Li ions through the interphase, thereby attenuating the impedance associated with Li‐ion migration within the SEI. This resistance attenuation is instrumental in alleviating the overpotentials, thereby significantly refining the electrochemical plating and stripping dynamics of Li metal electrodes.
Defining cornfield edge effect due to field microclimates
Authors: Licht Mark A. , White Tyler R. 
Published: June 2024

Plain Language SummaryAs profit margins become increasingly smaller for Midwest farmers, it is crucial to understand how a crop reacts to weather‐related stress. Cornfield edge effect is a new phenomenon Iowa farmers are experiencing where grain yield is lower at the field edge and progressively improves towards the field interior. Our objective was to verify if cornfield edge effect is occurring in Iowa along southern or western field edges when soybean is the adjacent field. And, if an edge effect is observed, determining the timing of the effect through the analysis of grain yield components. Field data collection was conducted in two regions of Iowa in 2019 and 2020 with observations at four distances from the field edge to interior. A field edge effect was detected in three of seven locations. We believe cornfield edge effect is occurring and that often it is a result of lower kernel numbers per ear and/or kernel weight.
The Electro‐Fenton Reaction in Chemistry Class
Authors: Lanfermann Philipp , Weidmann Christoph , Waitz Thomas 
Published: June 2024

AbstractIm vorliegenden Beitrag wird die Elektro‐Fenton‐Reaktion als nachhaltige Methode zur Beseitigung persistenter organischer Stoffe in Abwässern modellhaft nachvollzogen. Die Elektro‐Fenton‐Reaktion kombiniert dabei die elektrosynthetische Darstellung von Wasserstoffperoxid mit der Bildung hochreaktiver Hydroxyl‐ und Peroxyl‐Radikale, die organische Schadstoffe oxidativ mineralisieren können. Die am Abbau beteiligten Spezies und Reaktionen können durch den vorgeschlagenen experimentellen Unterrichtsgang anschaulich erarbeitet werden, wobei insbesondere Grundlagen der Elektrochemie, Katalyse und die Reaktivität von Radikalen als wichtige curricular angebundene Aspekte thematisiert werden.
Sphaeropsidin A C15–C16 Cross‐Metathesis Analogues with Potent Anticancer Activity
Authors: Wagh Sachin B. , Berthold Dino , Majeed Iram , Lewis L. Kevin , Schilter David , Mertens Birgit , Evidente Antonio , van Otterlo Willem A. L. , Mathieu Véronique , Kornienko Alexander 
Published: June 2024

AbstractWe recently discovered that sphaeropsidin A (SphA), a fungal metabolite from Diplodia cupressi, overcomes apoptosis resistance in cancer cells by inducing cellular shrinkage by impairing regulatory volume increase. Previously, we prepared a pyrene‐conjugated derivative of SphA by a cross‐metathesis reaction involving the phytotoxin's C15,C16‐alkene. This derivative's evaluation in a cancer cell panel revealed a significant increase in potency, with the IC50 values 5–10× lower than those displayed by the original natural product. Herein, we describe the preparation and anticancer evaluation of fifteen novel C15,C16‐alkene cross‐metathesis analogues in which the pyrene moiety was replaced with other aromatic or non‐aromatic hydrophobic groups. The idea for this replacement was to prepare a family of compounds that would not be predicted to be mutagenic compared with the original pyrene analogue. We predict several of our new compounds to be non‐mutagenic, while retaining the high potency of the original pyrene‐containing analogues. Examples of these potential lead compounds included those containing pentamethylphenyl and triphenylethylene pendant groups. As an additional feature of the current investigation, we prepared several deuterated pyrene‐containing compounds to overcome intellectual property issues associated with non‐patentability of the original pyrene derivative.
B‐N Co‐Doped Graphene: Stability and Catalytic Activity in Oxygen Reduction Reaction – A Theoretical Insight
Authors: Wang Jinlong , Guoa Jinmin , Liua Yang‐Yi , Lia Peng , Fanga Qiufeng , Li Xiao‐Chun , Song Wei 
Published: June 2024

AbstractWe systematically investigated the stable configurations and catalytic activity in the Oxygen Reduction Reaction (ORR) of graphene co‐doped with boron and nitrogen (B‐N) using first‐principles methods. Compared to single B/N doping, co‐doping with BN is energetically favored. We found that intermediate species of ORR process adsorb on boron atoms, which act as catalytic sites. The presence of neighboring nitrogen atoms around boron plays a crucial role in modulating the catalytic activity of boron. For the same adsorption configuration, the adsorption energy of the adsorbate increases with the number of neighboring nitrogen atoms around boron and generally correlates positively with the number of electrons gained by the adsorbate. Regarding the catalytic activity of ORR, excessively strong adsorption of adsorbates impedes their hydrogenation. The best substrates for ORR catalytic activity are B‐N‐graphene and N‐B2‐graphene, with the rate‐determining step being the hydrogenation of *OO and overpotentials of 0.49 V and 0.54 V, respectively.
Understanding the Factors That Contribute to Creating a Collaborative Psychological Formulation: A Qualitative Systematic Review
Authors: Thrower Naomi E. , Berry Katherine , Johnston Isobel , Morris Lydia 
Published: June 2024

ABSTRACTObjectivesCreating a formulation is one of the key competencies of a clinical psychologist and is understood to be important for guiding therapeutic input and understanding client distress. However, client experience of formulations can vary, with some reporting it is unhelpful and distressing. This novel review explores the experiences of clinicians and clients when creating a formulation, specifically the barriers and facilitators to collaborating on a formulation. This ultimately aims to improve client experience and engagement in formulation.MethodsA systematic search of PubMed, Web of Science, PsycINFO and EMBASE was conducted using PRISMA guidelines. The protocol was registered on PROSPERO. This search was conducted using terms related to ‘psychological formulation’ and ‘experience’. Nineteen qualitative papers met inclusion criteria and were appraised using the Critical Appraisal Skills Programme. Findings that pertained to formulation were thematically synthesised.ResultsThree analytical themes were identified: toleration of the formulation process—‘a necessary evil’, which highlights the potential emotional impact of formulation on the client and indicates the importance of responding to client readiness and expectations of formulation; development of the therapeutic relationship—‘it's like a two way thing, isn't it?’, which suggests that client empowerment, adapting to client needs and clinicians creating a safe and containing environment facilitated the formulation process; systemic factors—‘walking a tightrope’, which highlights the constraints of resources and team dynamics in therapists' ability to engage in collaborative formulation.ConclusionFacilitators to a collaborative formulation include the following: simple formulations, thorough assessment and preparation for formulation, ‘doing with’ activities such as timelines and diagrams and working environments that include supportive colleagues and time for reflection and training.
Development and Validation of Miniaturized Assays to Assess Protein Techno‐functional Properties
Authors: Ling Jordy Kim Ung , Gorelik Sergey , Subramanian Gomathy Sandhya , Sarwono Albertus Eka Yudistira , Lee Daryl , Antipina Maria N. , Ng Siew Bee 
Published: June 2024

AbstractTechno‐functional properties of protein isolates such as emulsification, foaming, and gelling serve as key indicators to determine their food applications. Conventional macro‐volume techniques used to measure these techno‐functional properties are usually time consuming, require large amounts of protein samples, and are impractical when diverse protein samples are handled at the early screening stage. To overcome these issues, we have developed scaled‐down (miniaturized) assays to test techno‐functional properties of protein samples. These assays are simple, efficient, and require <400 μl of protein solution. Specifically, the miniaturized emulsification and gelling assays require 25‐fold less protein than conventional macro‐volume techniques and the miniaturized foaming assay requires 100‐fold less sample. The performance of these assays has been thoroughly validated using conventional techno‐functional tests for each parameter. The protocols described herein offer high‐throughput screening capabilities, accelerating the testing process for protein techno‐functional properties and allowing for quick identification of samples of interest from diverse samples. © 2024 Wiley Periodicals LLC.Basic Protocol 1: Miniaturized emulsification assayAlternate Protocol 1: Conventional macro‐volume emulsification assayBasic Protocol 2: Miniaturized foaming assayAlternate Protocol 2: Conventional macro‐volume foaming assayBasic Protocol 3: Miniaturized gelling assayAlternate Protocol 3: Conventional macro‐volume gelling assay
Pressure‐Induced Enhancement in Chemical Looping Reforming of CH4: A Thermodynamic Analysis with Fe‐Based Oxygen Carriers
Authors: Zhang Xizhe , Cheng Nuo , Zhang Yuhan , Tian Sicong , Han Lujia 
Published: June 2024

AbstractChemical looping reforming of methane (CLRM) with Fe‐based oxygen carriers is widely acknowledged as an environmentally friendly and cost‐effective approach for syngas production, however, sintering‐caused deactivate of oxygen carriers at elevated temperatures of above 900 °C is a longstanding issue restricting the development of CLRM. Here, in order to reduce the reaction temperature without compromising the chemical‐looping CH4 conversion efficiency, we proposed a novel operation scheme of CLRM by manipulating the reaction pressure to shift the equilibrium of CH4 partial oxidation towards the forward direction based on the Le Chatelier's principle. The results from thermodynamic simulations showed that, at a fixed reaction temperature, the reduction in pressure led to the increase in CH4 conversion, H2 and CO selectivity, as well as carbon deposition rate of all investigated oxygen carriers. The pressure‐negative CLRM with Fe3O4, Fe2O3 and MgFe2O4 could reduce the reaction temperature to below 700 °C on the premise of a satisfactory CLRM performance. In a comprehensive consideration of the CLRM performance, energy consumption, and CH4 requirement, NiFe2O4 was the Fe‐based OCs best available for pressure‐negative CLRM, especially for an excellent syngas yield of 23.08 mmol/gOC. This study offered a new strategy to address sintering‐caused deactivation of materials in chemical looping from the reaction thermodynamics point of view.
“Point by point” source: The Chinese pine plantations in North China by evidence from mtDNA
Authors: Zhou Biao , Zhang Zijie , Zhang Hongjing , Li Yupeng , Ma Yanguang , Zhang Shubin , Niu Shihui , Li Yue 
Published: June 2024

AbstractThe geographical variation and domestication of tree species are an important part of the theory of forest introduction, and the tracing of the germplasm is the theoretical basis for the establishment of high‐quality plantations. Chinese pine (Pinus tabuliformis Carr.) is an important native timber tree species widely distributed in northern China, but it is unclear exactly where germplasm of the main Chinese pine plantation populations originated. Here, using two mtDNA markers, we analyzed 796 individuals representing 35 populations (matR marker), and 873 individuals representing 38 populations (nad5‐1 marker) of the major natural and artificial populations in northern China, respectively (Shanxi, Hebei and Liaoning provinces). The results confirmed that the core position of natural SX* populations (“*” means natural population) in the Chinese pine populations of northern China, the genetic diversity of HB and LN plantations was higher than that of natural SX* populations, and there was a large difference in genetic background within the groups of SX* and LN, HB showed the opposite. More importantly, we completed the “point by point” tracing of the HB and LN plantings. The results indicated that almost all HB populations originated from SX* (GDS*, ZTS*, GCS*, and THS*), which resulted in homogeneity of the genetic background of HB populations. Most of germplasm of the LN plantations originated from LN* (ZJS* and WF*), and the other part originated from GDS* (SX*), resulting in the large differences in the genetic background within the LN group. Our results provided a reliable theoretical basis for the scientific allocation, management, and utilization of Chinese pine populations in northern China, and for promoting the high‐quality establishment of Chinese pine plantations.
Comparison of seasonal viral prevalence supports honey bees as potential spring pathogen reservoirs for bumble bees
Authors: Wham Briana E. , McCormick Elyse C. , Carr Casey M. , Bracci Nicole R. , Heimann Ashley C. , Egner Timothy J. , Schneider M. Jesse , Hines Heather M. 
Published: June 2024

AbstractBee declines pose a serious risk to agricultural sustainability, wild plant diversity, and the commercial bee industry, generating local and global concerns about bee health. Parasites, including micro‐parasites and macro‐parasites, negatively impact bee population dynamics. Management of parasites requires an understanding of the cyclic trends in prevalence and the factors impacting these patterns. In this study, we advance understanding of parasite epidemiology and transmission among members of the bee community toward the goal of improving predictability of parasite prevalence seasonally. Honey bees and bumble bees were collected throughout an active season and across multiple overwintering periods. These bees were molecularly tested for two common bee viruses—deformed wing virus (DWV) and black queen cell virus (BQCV)—and morphologically screened for Vairimorpha spp., nematodes, and parasitic flies to determine whether these parasites exhibit unique seasonal trends, if overwintering behavior impacts parasite survival, and how these patterns differ between honey bees and bumble bees. The results suggest consistent seasonal trends between honey bees and bumble bees; however, these trends are parasite‐specific. Honey bees consistently exhibited a higher magnitude of viral prevalence compared with bumble bees. Both honey bees and bumble bees reduced viral prevalence over the winter; however, only in bumble bees did this drop to negligible prevalence each spring. These data suggest that honey bees may have a larger impact on parasite transmission, as they pose to reinfect bees which otherwise would have very low prevalence each spring and sustain high levels of infection in communities year‐round.