bluuebunny/crossref_metadata_2025_split huggingface dataset:
GLP-1 receptor agonists and weight loss in schizophrenia – past, present, and future
Authors: Trott Mike , Arnautovska Urska , Siskind Dan 
Published: June 2024

Purpose of review
People with schizophrenia experience three to five times higher prevalence of diabetes and obesity than the general population, contributing to a 20-year reduced lifespan. The impacts of weight gain extend beyond physical health, affecting people's self-esteem, quality of life, and triggering treatment nonadherence, leading to relapse and deteriorations in health. Clinical guidelines recommend patients with antipsychotic-induced weight gain are treated with cognitive behaviour therapy and lifestyle changes; however, effective treatments for obesity in schizophrenia are critically lacking. Glucagon-like peptide-1 receptor agonists (GLP-RAs) have shown large effects in weight loss in the general population; however, effects are less clear in people with schizophrenia. This review aims to assess the clinical trials that have been completed, are in progress, and directions for future trials.

Recent findings
To date, six clinical trials have been completed, four of which have published their findings. Three further trials are currently in progress.

Summary
Results from completed trials suggest that GLP-1RAs decrease weight in people with schizophrenia, however effect sizes are mostly smaller than studies based on the general population. Future trials could focus on dual or triple agonist agents, and/or explore the effects of GLP-1 s at antipsychotic medication commencement, to potentially prevent antipsychotic weight gain.
Safety and adherence to self-administered intravaginal 5-fluorouracil cream following cervical intraepithelial neoplasia (CIN) 2/3 treatment among HIV-positive women in Kenya: A phase 1 clinical trial
Authors: Mungo Chemtai , Omoto Jackton , Ogollah Cirilus , Owaya Antony , Rop Mercy , Rota Gershon , Bukusi Elizabeth A , Tang Jennifer , Rahangdale Lisa 
Published: June 2024

AbstractObjectiveTo determine the safety, tolerance, and adherence to self-administered intravaginal 5% fluorouracil (5FU) cream as adjuvant therapy following cervical intraepithelial neoplasia grade 2 or 3 (CIN2/3) treatment among women living with HIV (WLWH) in Kenya.MethodsA Phase I Pilot trial was performed among 12 WLWH in Kenya, aged 18–49 years between March 2023-February 2024 (Clinicaltrials.govNCT05362955). Participants self-administered 2g of 5FU intravaginally every other week for eight applications. Safety was assessed using a standardized grading scale, and adherence was evaluated using self-report, inspection of used applicators, and weighing of the study drug.ResultsThe mean age and CD4 count were 43.9 years and 781 cells/mm3, respectively. Seven (58%) had an 8th-grade education or less. All 12 reported at least one grade I adverse event (AE), 1 (8%) reported a grade 2 AE, no grade 3 or 4 AEs were reported. Increased vaginal discharge (n=9, 75%) and irritation (n=5, 42%), with a mean duration of 3.2 and 2.8 days, respectively, were the most commonly reported AEs. Provider-observed AEs included grade 1 cervical erythema and superficial abrasions. All participants tolerated all eight 5FU doses, and 96% adherence was demonstrated.ConclusionSelf-administered 5FU following CIN2/3 treatment among WLWH in Kisumu, Kenya, was safe, tolerable, and associated with high adherence. Randomized trials are needed to investigate whether adjuvant 5FU can improve treatment outcomes or serve as primary cervical precancer treatment in sub-Saharan Africa. A self-administered therapy may be transformative in increasing access to treatment and, hence, secondary prevention of cervical cancer.
Exploring the restorative environments in Bratislava using EEG and VR: a neuro-urbanism approach
Authors: Elsayed Mirame , Elshater Abeer , Shehayeb Dina , Finka Maros , Afifi Samy M.Z. 
Published: June 2024

PurposeResiding in a densely populated urban area possesses its allure; nonetheless, it can significantly impact physical and mental well-being owing to the persistent stress and information overload inherent in urban settings. This study aims to introduce a neuro-urbanism framework that can guide urban planners and designers in quantitatively evaluating individuals' responses to virtual simulated environments.Design/methodology/approachOur study consisted of two phases after randomly selecting six locations representing three types of urban areas in Bratislava, Slovakia: urban spaces, urban streets, and public parks. First, we conducted a Mentimeter live polling (dialogic survey fusion), followed by an experiment involving volunteer participants from the Slovak University of Technology. This experiment employed an electroencephalogram (EEG) with virtual reality headsets to virtually explore participants' responses to the selected locations.FindingsThe EEG signal analysis revealed significant differences in relaxation levels across the selected locations in this study. Urban streets with commercial activities promote mental well-being more effectively than public parks, challenging the preconception that restorative environments are exclusively confined to public parks.Originality/valueThe results demonstrate a replicable neuro-urbanism framework comprising three distinct stages: problem-based technology rooted in neuroscience, experimental setup and deliverables, and identification of restorative environments.
A qualitative evaluation of an in-school social norms approach intervention for reducing unhealthy snacking behaviours amongst secondary school students
Authors: Calvert Sian , Dempsey Robert , Povey Rachel 
Published: June 2024

PurposeThe Social Norms Approach (SNA) is a health behaviour intervention which promotes positive behaviour change by challenging and reducing misperceived social norms of peer behaviours and attitudes. This study reports a novel qualitative evaluation of an in-school SNA intervention which aimed to reduce 11-to-12-year-old students’ unhealthy snacking behaviours by reducing misperceived peer norms.Design/methodology/approachA qualitative evaluation of seven teachers’ and eighteen students’ experiences of taking part in the SNA intervention based on focus group discussions and an open-ended survey.FindingsAn inductive reflexive thematic analysis indicated that the SNA intervention was an effective and engaging means of delivering normative feedback to younger adolescents. The use of a paper-and-pens creative poster-making activity, where students were tasked with designing the intervention materials featuring normative feedback based on their baseline data, encouraged students to discuss and reflect on the discrepancies between their perceived norms and the actual reported unhealthy snacking norms. Challenges were identified with ensuring intervention fidelity and in students’ understanding of how to record survey responses using Likert scales.Originality/valueThis study demonstrates the usefulness of exploring post-intervention perceptions of SNA interventions, particularly from the perspective of the intended recipients. The study also provides useful information for those intending to develop in-school SNA interventions in the future, particularly the importance of involving participants in the designing of intervention materials as a means of promoting engagement with an SNA-based dietary behaviour intervention.
Exploring and evaluating the development of an open application programming interface (Open API) architecture for the fintech services ecosystem
Authors: Wang Jen Sheng 
Published: June 2024

PurposeThe Open API (application programming interface) architecture will play an important role in promoting future FinTech service applications; however, it involves user data, and the current specialization and progression are less visible. Therefore, an evaluation framework for Open API development in the FinTech service ecosystem is constructed in this study.Design/methodology/approachThis study preliminarily selects the four most important key objects and factors of this ecosystem and conducts expert interviews to revise the evaluation framework. Then, this study uses the fuzzy analytic hierarchy process (FAHP) to evaluate the objects and their factor weights and finally uses the FAHP analysis results to further apply the evaluation based on distance from average solution (EDAS) approach to explore the strategy optimization scenarios.FindingsAccording to the analysis results, the co-creation object and productivity object are the two most significant objects, with weights of 0.275 and 0.272, respectively. The analysis shows that FinTech-related companies expect to increase productivity through co-creation. Finally, the results also indicate that mobile payment is the best Open API application scenario in the FinTech service ecosystem, followed by online banking. These results illustrate strategic and management implications.Originality/valueThis study screens key evaluation criteria with a literature review and expert questionnaire interviews to process quantitative research. It can determine the weights of objectives and criteria to clarify the strength of influence between the objectives and criteria. Next, this study measures the probable performance of Open API applied in various FinTech service ecosystem scenarios.
Customer experience management (CXM) and new product success: an empirical investigation
Authors: Athaide Gerard A. , Zhang Jason Q. , Klink Richard R. 
Published: June 2024

PurposeCustomer experience management (CXM) and Innovation are two important capabilities on which businesses compete today. However, research to date has not empirically investigated their potential symbiotic relationship. Specifically, does better CXM improve innovation; similarly, does better innovation improve CXM? As a starting point, our research focuses on the former: how does effective CXM correlate with innovation success?Design/methodology/approachData was collected by querying marketing managers from 251 goods and services firms involved in CX design and implementation. Managers answered questions related to their innovation efforts, customer experience management initiatives, and innovation outcomes. Cluster analysis was used to identify a taxonomy of CXM approaches contingent upon environmental factors (market turbulence, competitive intensity, and technological turbulence).FindingsOur research found that higher levels of CXM engagement result in greater innovation success – i.e. higher success rates, revenues, and profits from new products or services. In addition, we find that there are three distinct approaches to CXM: (1) Extensive CXM approach (43% of firms in our sample); (2) Moderate CXM approach (39%); and (3) Limited CXM approach (18%). Firms with an extensive CXM approach operate in intensely competitive environments that are characterized by very high technological turbulence. Firms that employ a limited CXM approach operate in environments with the lowest levels of competitive intensity and technological change. Market turbulence did not factor into the choice of CXM approach.Originality/valueTo our knowledge, our study is the first to provide empirical evidence that firms adopt different CXM approaches. Further, we identify factors external to the firm that are considered when selecting these CXM approaches; namely, market turbulence, competitive intensity, and technological turbulence. Finally, our findings related to CXM approaches and innovation success indicate that managers should make investments in CXM to help improve innovation.
The role of firm complexity in the relationship between integrated reporting and earnings management
Authors: Donkor Augustine , Trireksani Terri , Djajadikerta Hadrian Geri 
Published: June 2024

Purpose
This study aims to evaluate the relationship between integrated reporting and management’s opportunistic behavior (i.e., accrual and real earnings management) and the moderating role of firm complexity.

Design/methodology/approach
Data of firms at the Johannesburg Stock Exchange were collected and analyzed. The Johannesburg Stock Exchange is currently the primary exchange that mandates the practice of integrated reporting. Regression estimation models and robustness tests were applied to the analysis.

Findings
This study concludes that integrated reporting quality reduces firms’ accrual and real earnings management practices. It further concludes that the significant negative effect of integrated reporting quality on firms’ earnings management practices is impeded by higher firm complexity.

Originality/value
This study enhances the literature on the behavioral effect of a combined financial and sustainability disclosure practice on both accrual and real earnings management, specifically targeting South Africa’s listed companies – the primary market currently mandates integrated reporting practice.
Does top executive gender diversity matter for the value relevance of ESG controversies? Empirical evidence from European tech firms
Authors: Al-Hiyari Ahmad 
Published: June 2024

Purpose
Interest in environmental, social and governance (ESG) controversies is acquiring great relevance in the business and academic communities. Nonetheless, previous studies in the area have devoted little attention to how the market views ESG controversies. Against this backdrop, this paper aims to investigate whether ESG controversies are value-relevant to investors, as reflected in equity values. It also investigates whether top management team (TMT) gender diversity is likely to affect the association between ESG controversies and equity market values in the context of high-tech firms.

Design/methodology/approach
This paper uses a sample of high-tech firms listed on the STOXX 600 index during the period 2006–2022. The ESG data for the sample is retrieved from the Refinitiv Eikon database. This paper adopts a fixed-effect panel regression to test the hypotheses.

Findings
Based on the Ohlson’s (1995) valuation framework, the authors find evidence that ESG controversies are associated with a lower market valuation, suggesting that shareholders perceive ESG controversies as conveying negative information about future performance. The authors also find evidence that TMT gender diversity negatively moderates the relationship between ESG controversies and equity values, indicating that TMT gender diversity alleviates the detrimental effect of corporate controversies. These results remain consistent when using the return model of Easton and Harris (1991).

Originality/value
This paper throws more light on the economic consequences of ESG controversies in European high-tech firms. This is particularly important due to the increasing importance of ESG criteria in guiding investment choices. This paper also adds to the current literature by providing new evidence that the value-relevance of ESG controversies is affected by TMT gender diversity.
Gamification in cybersecurity education; a state of the art review and research agenda
Authors: Pramod Dhanya 
Published: June 2024

PurposeThe growth of the internet, access to technology and rapid digital transformations have paved the way for developing attack surfaces for individuals and organizations. There is a dire need to provide cybersecurity awareness most effectively. Gamification-based platforms have evolved to make cybersecurity education more engaging and effective. This study explores the gamification platforms available for cybersecurity training and awareness, the extent to which they are used and their benefits and challenges.Design/methodology/approachPRISMA 2020 was used to conduct the systematic literature review.FindingsThe study comprehends the game design elements and their role in the effectiveness of cybersecurity training and awareness. The study unveils that traditional education methodologies are insignificant in cybersecurity awareness, and gamification-based platforms are more beneficial. The paper summarizes the implications of the findings and further postulates future research directions.Originality/valueThis work comprehends the various forms of gamification platforms and frameworks available for cybersecurity training and will motivate further development of gamification platforms. This paper will help academia, private and public organizations and game designers enhance their gamification-based cybersecurity education interventions.
The effect of restatements on office-level audit quality
Authors: Nash Jonathan , Bailey Cristina 
Published: June 2024

Purpose
This study aims to provide evidence on how the issuance of a nonreliance restatement affects non-restating clients of the same audit office.

Design/methodology/approach
To test the effect of restatement issuance on office-level quality, this study runs regressions using both input- and output-based measures of audit quality.

Findings
This study finds that in the years where one or more clients of an audit office issue a restatement, audit effort is lower for non-restating clients of the same office. When two or more clients issue a restatement, other clients are charged lower audit fees, file later and are more likely to experience an audit failure.

Originality/value
This study contributes to the literature on office-level audit quality and provides an explanation for the longitudinal correlation of office-level audit failures.
Exploring the causal complexity of business models with organizational performance: a study for the pharmaceutical industry
Authors: Panchal Dinesh B. , Krishnamoorthy Bala , Bhattacharyya Som Sekhar 
Published: June 2024

PurposeAuthors analyze a business model (BM) based on organizational performance. BMs are strategic tools used to achieve high performance. This study is based on two characteristics of causal complexity: conjunction and equifinality. Authors also examine the applicability of causal asymmetry in the relationship between BMs and organizational performance.Design/methodology/approachGenerally, the relationship between BM elements and organizational performance is analyzed using a correlational approach. This relationship is marked by causal complexity, which cannot be analyzed via such approach. Authors applied a fuzzy-set qualitative comparative analysis with data from three time-periods and two performance variables for pharmaceutical firms.FindingsQualitative comparative analysis revealed that high performance resulted from configurations (combinations) of BM elements and not from the effects of individual elements. In addition, multiple configurations are available for achieving high performance. Causal asymmetry was observed in the configuration of the BM elements for high and low performances.Research limitations/implicationsUsing qualitative comparative analysis of data sets from three time-periods in the context of the pharmaceutical industry BM, authors integrated the theoretical constructs of causal complexity, namely conjunction, equifinality and causal asymmetry.Practical implicationsFindings related to conjunctions will help managers shift their focus from individual BM elements to combinations of BM elements. Additionally, the findings related to equifinality and causal asymmetry will allow flexibility in designing their company’s BM according to the resource constraints their company faces.Originality/valueThis was one of the first few studies on BMs using the twin indicators of the organizational performance relationship and causal complexity.
Vitality of autologous retromolar bone grafts for alveolar ridge augmentation after a 3‐months healing period: A prospective histomorphometrical analysis
Authors: Stricker Andres , Fretwurst Tobias , Abdullayeva Arzu , Bosshardt Dieter , Aghaloo Tara , Duttenhöfer Fabian , Cordaro Luca , Nelson Katja , Gross Christian 
Published: June 2024

AbstractObjectivesThe incorporation of retromolar bone grafts used for alveolar ridge augmentation is not well understood. This prospective observational study aims to supply histomorphometrical data from bone graft biopsies taken at the time of retrieval and after a 3‐month healing period using patient‐matched biopsies.Materials and MethodsIn 17 patients, trephine biopsies of the graft were acquired at the time of graft retrieval and after a 3‐month healing period. The biopsies were compared histomorphometrically regarding the number of osteocytes, appearance of osteocyte lacunae, quantity, surface area, and activity of the Haversian canals.ResultsAll grafts appeared clinically stable after screw removal and 17 implants were placed. Histomorphometric analysis revealed no significant difference in the number of osteocytes (p = .413), osteocyte lacunae (p = .611), the ratio of filled/empty osteocyte lacunae (p = .467) and active Haversian canals (p = .495) between the biopsies retrieved after a 3‐months healing period with those at the time of grafting. The only significant difference was noted in the mean surface area of the Haversian canals (p = .002). Specifically, the grafts post 3‐month healing showed a significantly larger mean area (0.069 mm2) compared to the time of grafting (0.029 mm2).ConclusionThis study demonstrates, compared to other data, a high rate of vital structures in retromolar bone block grafts after 3 months of healing, exhibiting the same histological features in comparison to the biopsies from the native alveolar ridge. Standard histomorphometrical parameters, e.g., the amount of filled or empty osteocyte lacunae for the description of the vitality of the graft need to be reappraised.
Low overhead vector codes with combination property and zigzag decoding for edge‐aided computing in UAV network
Authors: Dai Mingjun , Huang Ronghao , Wang Jinjin , Li Bingchun 
Published: June 2024

AbstractCodes that possess combination property (CP) and zigzag decoding (ZD) simultaneously (CP‐ZD) has broad application into edge aided distributed systems, including distributed storage, coded distributed computing (CDC), and CDC‐structured distributed training. Existing CP‐ZD code designs are based on scalar code, where one node stores exactly one encoded packet. The drawback is that the induced overhead is high. In order to significantly reduce the overhead, vector CP‐ZD codes are designed, where vector means the number of stored encoded packets in one node is extended from one to multiple. More specifically, in detailed code construction, cyclic shift is proposed, and the shifts are carefully designed for cases that each node stores two, three, and four packets, respectively. Comparisons show that the overhead is reduced significantly.