bluuebunny/crossref_metadata_2025_split huggingface dataset:
Optimization and validation of multiresidual extraction methods for pharmaceuticals in Soil, Lettuce, and Earthworms
Authors: Mravcová Ludmila , Amrichová Anna , Navrkalová Jitka , Hamplová Marie , Sedlář Marian , Gargošová Helena Zlámalová , Fučík Jan 
Published: April 2024

AbstractThe presence of human and veterinary pharmaceuticals (PhACs) in the environment poses potential risks. To comprehensively assess these risks, robust multiresidual analytical methods are essential for determining a broad spectrum of PhAC classes in various environmental compartments (soil, plants, and soil organisms). This study optimized extraction methods for analyzing over 40 PhACs from various matrices, including soil, lettuce, and earthworms. A four-step ultrasonic extraction method with varying extraction conditions and subsequent solid phase extraction was developed for soil samples. QuEChERS methods were optimized for extracting PhACs from lettuce and earthworm samples, addressing a literature gap in these less-studied matrices. The quantification of PhACs in soil, lettuce, and earthworm extracts was performed using a single LC–MS/MS method. Following thorough method validation, earthworms and lettuce were exposed to a mixture of 27 pharmaceuticals in a soil environment. The method validation results demonstrated the robustness of these methods for a broad spectrum of PhACs. Specifically, 29 out of 42 PhACs were extracted with an average efficiency > 50% and RSD < 30% from the soil; 40 out of 42 PhACs exhibited average efficiency > 50% and %RSD < 30% from the earthworms, while 39 out of 42 PhACs showed average efficiency > 50% and RSD < 30% from the lettuce. Exposure experiments confirmed the viability of these methods for quantifying a diverse range of PhACs in different environmental compartments. This study presents three thoroughly validated methods for determining more than 40 PhACs in diverse matrices, enabling a comprehensive assessment of PhAC dissemination in the environment.
Graphical Abstract
Multiplicative arithmetic functions and the generalized Ewens measure
Authors: Elboim Dor , Gorodetsky Ofir 
Published: April 2024

AbstractRandom integers, sampled uniformly from [1, x], share similarities with random permutations, sampled uniformly from Sn. These similarities include the Erdős–Kac theorem on the distribution of the number of prime factors of a random integer, and Billingsley’s theorem on the largest prime factors of a random integer. In this paper we extend this analogy to non-uniform distributions.Given a multiplicative function α: ℕ → ℝ≥0, one may associate with it a measure on the integers in [1, x], where n is sampled with probability proportional to the value α(n). Analogously, given a sequence {θi}i≥1 of non-negative reals, one may associate with it a measure on Sn that assigns to a permutation a probability proportional to a product of weights over the cycles of the permutation. This measure is known as the generalized Ewens measure.We study the case where the mean value of α over primes tends to some positive θ, as well as the weights α(p) ≈ (log p)γ. In both cases, we obtain results in the integer setting which are in agreement with those in the permutation setting.
Adeno-associated Virus-mediated Ezh2 Knockdown Reduced the Increment of Newborn Neurons Induced by Forebrain Ischemia in Gerbil Dentate Gyrus
Authors: Sehara Yoshihide , Hashimotodani Yuki , Watano Ryota , Ohba Kenji , Uchibori Ryosuke , Shimazaki Kuniko , Kawai Kensuke , Mizukami Hiroaki 
Published: April 2024

AbstractIt is established that neurogenesis of dentate gyrus is increased after ischemic insult, although the regulatory mechanisms have not yet been elucidated. In this study, we focused on Ezh2 which suppresses gene expression through catalyzing trimethylation of lysine 27 of histone 3. Male gerbils were injected with adeno-associated virus (AAV) carrying shRNA targeting to Ezh2 into right dentate gyrus 2 weeks prior to forebrain ischemia. One week after ischemia, animals were injected with thymidine analogue to label proliferating cells. Three weeks after ischemia, animals were killed for histological analysis. AAV-mediated knockdown of Ezh2 significantly decreased the ischemia-induced increment of proliferating cells, and the proliferated cells after ischemia showed significantly longer migration from subgranular zone (SGZ), compared to the control group. Furthermore, the number of neural stem cells in SGZ significantly decreased after ischemia with Ezh2 knockdown group. Of note, Ezh2 knockdown did not affect the number of proliferating cells or the migration from SGZ in the non-ischemic condition. Our data showed that, specifically after ischemia, Ezh2 knockdown shifted the balance between self-renewal and differentiation toward differentiation in adult dentate gyrus.
Stones that Tell Stories
Authors: Pereira Dolores 
Published: April 2024

AbstractWhen a historical building, monument, or cultural heritage artifact is affected by a natural or anthropic event, the first reaction is to recover and restore to maintain our heritage for the next generations. If they are made of stone, some are completely destroyed, but it is often still possible to recognize the facts that made them a cultural item. In many cases, the marks of violent actions are visible on the stone, especially if the impacts came from a non-massive destructive weapon, such as rifle bullet marks or cannon marks from centuries ago, with a lower level of destruction than today. These marks are also part of our heritage and, as a reminder of the history of our cities and countries for generations, it is recommended that they be preserved as a testimony to avoid the repetition of unnecessary violence. This is the aim of the stones that tell stories.
The habitat utilization and environmental resilience of Homo heidelbergensis in Europe
Authors: Trájer Attila J. 
Published: April 2024

AbstractThe European populations of Homo heidelbergensis may have contributed to the genetic heritage of modern Eurasians. A better understanding of the possible effects of palaeoenvironmental alterations on the evolution of ancient humans can help to understand the origin of developed traits. For this purpose, the spatiotemporal alterations of physical factors were modelled in Europe for the period of 670–190 ka, covering the existence of Homo heidelbergensis in Europe. The factors included the following: paleoclimatic conditions, climatic suitability values of ancient humans, two prey species, and the European beech. Furthermore, the distribution and features of wood used for toolmaking were also investigated. Finally, changes in the relative mortality risk, the percentage of the body covered by clothing, and daily energy expenditure values in the coldest quarter of the year were modelled. The results suggest that H. heidelbergensis inhabited dominantly temperate regions in Europe where prey such as red deer were present. In the northern regions, European beech trees were abundant. When making wood tools, they preferred relatively light but not the strongest woods, which were readily available in the vicinity of the sites. Although hard and heavy woods were also occasionally used, at a European level, significant changes were observed in the relative mortality risk, the percentage of the body covered by clothing, and daily energy expenditure values during the period of 670–190 ka. However, substantial differences between archaeological sites in these values, indicating somewhat ecological variations, were not found during the studied period.
Examination of Drone Usage in Estimating Hardwood Plantations Structural Metrics
Authors: Corbin Tyler , Bataineh Mohammad 
Published: April 2024

AbstractPlanting hardwood trees on retired marginal agricultural land is one of the main strategies used to restore forested wetlands. Evaluating effectiveness of wetland restoration requires efficient monitoring to evaluate recovery trajectories and desired conditions. Recent advancements in unmanned aerial system (UAS) technologies have prompted wide-scale adoption of UAS platforms in providing a range of ecological data. In this study, we examined the use of UAS Structure from Motion (SfM) derived point clouds in estimating tree density, canopy height, and percent canopy cover for bottomland hardwood plantations within four wetland reserve easements. Using a local maxima approach for individual tree detection produced plantation level estimates with mean absolute errors of 150 trees per hectare, 0.5 m, and 18.4% for tree density, canopy height, and percent canopy cover, respectively. At the plot level, UAS-derived tree counts (r = 0.53, p < 0.01) and canopy height (r = 0.57, p < 0.01) were significantly correlated with ground-based estimates. We demonstrate that UAS-SfM is a viable method of assessing bottomland hardwood plantations for applications that require precision levels congruent with the mean absolute errors reported here. The accuracy of tree density estimates was reliant upon specific local maxima window parameters relative to stand conditions. Therefore, acquisition of leaf-off and leaf-on imagery may allow for better individual tree detection and subsequently more accurate tree density and other structural attributes.
The partnerships between hermit crabs and sea anemones: an overview
Authors: Karplus Ilan 
Published: April 2024

AbstractThe hermit crab-sea anemone (HCA) partnership is a common facultative mutualism. The anemone protects its host from predators such as cephalopods and shell crushing crabs by its stinging cells. The crab provides the anemone with a hard substrate and increased access to oxygenated water and food and in some cases with protection from predators. These partnerships are extremely diverse and complex. This overview addresses issues related to formation of the associations, the early history of these partnerships, placement of anemones on the hermit crab shell, intra and interspecific competition amongst hermit crabs over sea anemones, costs and benefits for crab and anemone from being associated and the evolution of these partnerships based on molecular phylogenies using nuclear and mitochondrial markers.
Control of Discrete Event Systems by Using Symbolic Transition Model: An Application to Power Grids
Authors: Özbaltan Mete 
Published: April 2024

AbstractIn this paper, a new symbolic modeling framework is proposed for the control of discrete event systems (discrete controller synthesis). Reactive infinite-state systems are generally dynamic systems with inputs and outputs. Modeling the outputs in existing symbolic modeling methods for reactive infinite-state systems has not been extensively discussed in the literature. It is crucial to realistically model the outputs and obtain reliable controllers. One of the main contributions and innovations in this study is the ability to symbolically model their output. In this direction, symbolic transition models are offered, where events are defined as guarded symbolic transitions. The framework considers input/output reactive infinite-state systems to satisfy safety and optimization objectives. Effective algorithms and safety control policies are offered to solve the safety control problem (i.e., satisfy the safety objective) for input/output infinite-state systems. Another contribution in this work provides optimization targets within a given cost function based on state transitions, without specifying the target states. The framework is then applied to power grids to demonstrate the effectiveness of the symbolic transition models and experimentally evaluate the new control algorithms. The results showed that the approach is very effective compared to other approaches found in the literature. The computation times required to achieve both safety and optimization objectives are obtained relatively quickly compared to other deterministic methods found in the literature.
Photocatalytic degradation of biological contaminant (E. coli) in drinking water under direct natural sunlight irradiation using incorporation of green synthesized TiO2, Fe2O3 nanoparticles
Authors: Abd Elmohsen Sohila A. , Daigham Ghadir E. , Mohmed Samah A. , Sidkey Nagwa M. 
Published: April 2024

Abstract
Globally, there is a severe problem of widespread water contamination. Adsorption and photocatalytic degradation are considered the most suitable methods for removing these water pollutants because of their simplicity, environmental friendliness, and capacity to generate high-quality water. By a completely green route, in this recent study, the fungus Aspergillus tubingensis was able to synthesize TiO2 and Fe2O3 NPs with an average diameter of 28.0 and 65 nm, respectively. The smallest NPs diameters were produced when the precursor salt concentrations were 10−3 M and 10−2 M for TiO2 and Fe2O3, respectively, at pH 3 and an incubation time of 72 h. The biosynthesized NPs were characterized using DLS, TEM, EDX, and VSM. They were then applied in the preparation of titanium-iron nanocomposites with different ratios (1:1, 1:2, and 2:1 (w/w)) and characterized by FTIR and XRD. In this study, Escherichia coli (E. coli) was photo-catalytically inactivated using a TiO2–Fe2O3 nanocomposite as a photocatalyst in the presence of direct sunlight. This material’s photocatalytic performance was evaluated in comparison to that of TiO2 and Fe2O3 NPs. After 60 min of exposure to direct sunlight, the cell death was estimated as 97.97%, 99.32%, 89.06%, 30.96%, and 25.14% in the presence of TF-1, TF-2, TF-3, TiO2, and Fe2O3, respectively. Under direct natural sunlight irradiation for 60 min, TiO2 and Fe2O3 nanoparticles alone have the least impact on E. coli, whereas TF-2 nanocomposite has a higher level of photocatalytic bacterial inactivation competency than TF-1 and TF-3 nanocomposites. No significant toxicity has been observed for TF-2-treated water samples in the toxicity assessment.
Dietary Modification Combined with Nutrition Education and Counseling for Metabolic Comorbidities in Multiple Sclerosis: Implications for Clinical Practice and Research
Authors: Allogmanny Shoroog , Probst Yasmine 
Published: April 2024

Abstract
Purpose of Review
Metabolic comorbidities such as obesity, diabetes, hypertension, and dyslipidemia are common to multiple sclerosis (MS) and are associated with negative outcomes of the disease. Dietary intervention has the potential to improve MS co-morbidities; thus, it is a high priority for people living with MS to self-manage their disease. The present review aimed to summarize the recent evidence on the impacts of combining dietary modification with nutrition education and counseling on managing metabolic comorbidity markers in MS.

Recent Findings
Evidence suggests important roles for tailored dietary change strategies and nutrition education and counseling in managing metabolic comorbidities for MS. There is also indirect evidence suggesting a relationship between dietary fiber, the gut microbiome, and improved metabolic markers in MS, highlighting the need for more research in this area. For people living with MS, addressing both barriers and facilitators to dietary changes through behavior change techniques can help them achieve sustainable and tailored dietary behavior changes. This will support person-centered care, ultimately improving metabolic comorbidity outcomes.

Summary
Metabolic comorbidities in MS are considered modifiable diseases that can be prevented and managed by changes in dietary behavior. However, the impact of targeted dietary interventions on mitigating MS-related metabolic comorbidities remains inadequately explored. Therefore, this review has provided insights into recommendations to inform future best practices in MS. Further well-designed studies based on tailored dietary strategies applying behavior change theories are needed to address the underlying determinants of dietary practice in this population.
Rapid identification of Ips sexdentatus (Boerner, 1766) (Curculionidae) from adults and frass with real-time PCR based on probe technology
Authors: Rizzo D. , Zubieta C. G. , Carli M. , Marrucci A. , Ranaldi C. , Palmigiano B. , Bartolini L. , Pennacchio F. , Bracalini M. , Garonna A. P. , Panzavolta T. , Moriconi M. 
Published: April 2024

AbstractA molecular tool has been developed for the molecular identification of Ips sexdentatus (Börner 1776) (Coleoptera Curculionidae Scolytidae), the well-known six thooted bark beetle, widely distributed in Eurasia, where it infests several species of the genus Pinus and occasionally a few conifer species of the genera Abies, Larix and Picea. The developed test can be useful both in countries where I. sexdentatus is handled as a quarantine species and, to greater reason, in Europe to discriminate biological traces of this commonly found beetle from those produced by regulated pests. The protocol is based on real-time PCR with TaqMan probe technology and has been developed on whole insect bodies (adults) as well as on artificial frass contaminated by DNA of the beetle. The molecular test developed here for both direct and indirect identification of I. sexdentatus has proven effective in terms of analytical specificity, analytical sensitivity, reliability and reproducibility. The recommended protocol is a practical diagnostic tool allowing a rapid identification of the six toothed bark beetle in the presence of any biological trace of other xylophagous pests collected at points of entry during phytosanitary surveys.
Analysis of activity rhythm and behavior pattern for plateau pika in degraded alpine meadow
Authors: Su Xiaoxue , Li Xilai , Sun Huafang , Song Zihan 
Published: April 2024

AbstractThis paper proposes a behavior observation method for plateau pika (Ochotona curzoniae) in degraded alpine meadow in the Source Zone of the Yellow River (SZYR) on the Qinghai–Tibet Plateau based on continuous monitoring videos to observe its activity rhythm. The video surveillance cameras are installed facing toward degraded alpine meadow in the SZYR and run from March 2021 to February 2022 to record time allocation of plateau pika behavior (i.e., digging, foraging, guarding, moving and other behaviors) and its daily, monthly, and seasonal activity rhythm. The results indicate that: (1) The most active ground activity time is between 10:00 and 16:00, meanwhile it is inactive at night, which proves it plateau pika is diurnal animals. (2) Digging and foraging are frequently occurring behaviors among its daily activities, which occurs from 9:00 to 12:00 and 16:00. (3) Compare to other season, winter sees relatively frequent occurrences of digging and foraging according to the seasonal analysis results. (4) From annual perspective, digging and foraging accounted for 66.13% of plateau pika activity, while guarding accounted for 13.35%, moving accounted for 11.64%, and other behaviors accounted for 8.88%. There is a significant difference in the frequency of each behavior between the two groups (P < 0.05). The behavior observation method using video surveillance camera contributes to behavioral ecology information of plateau pika.
The study of the natural frequency evolution and numerical simulation of retrogressive landslides
Authors: Zhao Liuyuan , Wu Zhixiang , Shi Anchi , Xie Mowen , Du Yan , Wu Simiao 
Published: April 2024

AbstractA retrogressive landslide is influenced by the cyclical fluctuations in reservoir water levels is considered a common natural disaster. Tension cracks are important indicators for assessing landslide status in the case of retrogressive landslides. Displacement monitoring is a commonly used method and provides an intuitive reflection of the landslide deformation; however, it does not directly indicate the depth of the tension cracks. Based on the principles of vibrational dynamics, a retrogressive landslide is proposed to be initially classified as a single-mass spring oscillator model before the development of cracks. Following the development of tension cracks, the model can be classified as a double-mass spring oscillator model. The model patterns are verified through numerical simulations using ABAQUS. Based on the numerical simulations, with an increase in the number of reservoir water cycle fluctuations, the displacement and stress of the landslide exhibit periodic growth. However, during displacement growth, the tension cracks do not necessarily increase. As the tension cracks deepen, the landslide transitions from a single-mass spring oscillator model to a double-mass spring oscillator model, with the appearance of a second-order natural frequency. Moreover, as the tension cracks deepen, the numerical values of the natural frequency change. The maximum change in first-order natural frequency is 3.5 Hz. The maximum change in second-order natural frequency is 4.5 Hz. The variation in the natural frequency can reflect the depth of development of the landslide's tension cracks and, consequently, indicate changes in the stability state of the landslide.
A Deep Learning Approach for Digital Color Reconstruction of Van Gogh’s Paintings Using Unpaired Areas Under the Frame
Authors: Parvathaneni Tirumala Sai Ram , Pisarenco Maxim , Onvlee Hans 
Published: April 2024

AbstractFactors such as dirt accumulation, aging of paint materials and chemical reactions with the surrounding atmosphere lead to alteration and degradation of paintings. As a result, colors in the paintings can change. Van Gogh’s paintings are no exception to this process, and virtual reconstruction of the original colors is a very challenging problem. In this work we propose a novel approach for color reconstruction that does not require any pre-existing digital reconstructions, physical reproductions or artificial aging experiments, and relies purely on the data within the painting. We exploit the fact that areas of the painting located under the frame are typically well-preserved (mainly due to the protection from light exposure and dirt accumulation offered by the frame) and contain colors which are relatively close to their original look. Inspired by the recent advances in machine learning techniques for unpaired image-to-image translation, a practical weakly supervised approach for digital color reconstruction is formulated. Moreover, its performance is demonstrated for paintings by Vincent van Gogh. To our knowledge, this is the first time that a method for color reconstruction that relies purely on the data available within one painting is described in literature.
Millet-Based Food Products: An Overview
Authors: Siroha Anil Kumar , Bangar Sneh Punia 
Published: April 2024

Abstract
Purpose of Review
Climate change has the potential to induce increased aridity in soils, high temperatures, and reduced water resources, consequently exerting a direct impact on food security. This scenario can lead to heightened food prices and a decreased availability of food resources. Therefore, there is a need to search for non-traditional food crops that may be grown in adverse environmental conditions. Millets, possessing nutritional value comparable to traditional crops, can be cultivated in challenging conditions, making them versatile for various food applications. Because they are gluten-free, millet products are beneficial for persons with celiac disease.

Recent Findings
Millets find applications in probiotics, prebiotics, and alcoholic and non-alcoholic beverages. Millets are widely used to prepare bakery products, i.e., bread, biscuits, and cookies. Products formulated from millet had some drawbacks related to taste, texture, and anti-nutrient factors. Compared to wheat, millet products are the least acceptable. So, to improve its acceptability, products are prepared by blending millet flour with wheat flour.

Summary
The development of various products and their consumer acceptability is discussed in this article. Millet crops may be a good substitute for conventional crops for food applications. This review explores the manifold food applications of millets.