bluuebunny/crossref_metadata_2025_split huggingface dataset:
PW01-59 - Effects Of An Internet Based Assessment Of Child And Adolescent Psychopathology (Dawba) On Clinical Decision Making
Authors: Kuhn C. , Winkler Metzke C. , Aebi M. , Steinhausen H.-C. 
Published: June 2010

ObjectivesThe main objective was to examine agreement between the internet based Development and Well-Being Assessment (DAWBA) generated diagnoses and clinical diagnoses. Second, we aimed to explore how disclosure of the DAWBA-diagnosis before clinical decision making influenced the clinicians diagnosis. Third, whether there were differences of influence for different categories of disorders. Last, we examined how the use of DAWBA information affected identification of co-morbidities.Methods315 patients from outpatient clinics were randomised into two groups. In 177 cases the clinician was informed about DAWBA diagnosis, in 155 cases the clinican was blind to DAWBA information. DAWBA is an internet based package of questionnaires and rating techniques designed to generate psychiatric ICD10 or DSM IV diagnoses for 5- 17 year old children and adolescents. Information from parents, teachers and self-reports are brought together by a computer programme that predicts likely diagnoses. An expert rater decides on the diagnosis by synopsis of these different inputs.ResultsDAWBA diagnoses and clinical diagnosis without information from DAWBA showed acceptable agreement with Cohens kappa 0,26 for emotional disorders, kappa of 0,29 for hyperactive disorders and kappa of 0.31 for disruptive disorders.There was a significant effect on clinical diagnoses for emotional disorders for disclosure of DAWBA (kappa of 0.26 without DAWBA information versus kappa of 0,52 with information, Fishers z of p< 0,05)There was no significant effect of information about DAWBA-diagnosis considering comorbidities.ConclusionsDAWBA showed the most pronounced effect on clinical diagnoses for emotional disorders in children and adolescents.
PW01-61 - Behavioural Dependences In Adolescents And Young Adults: Results From An Observational Study
Authors: Martinotti G. , Villella C. , Di Nicola M. , Cassano M. , Petruccelli F. , Conte G. , Janiri L. 
Published: June 2010

IntroductionOur study aims to assess the prevalence of behavioural addictions in an adolescent populations, evaluating the effects of gender and age, and to assess the correlations and associations between different behavioural addictions.MethodsA population of 2853 students (1142 F and 1711 M, mean age 16.7± 1.9) was assessed in order to evaluate the prevalence of behavioural dependences such as Pathological Gambling (PG), Compulsive Buying (CB), Exercise Addiction (EA), Internet Addiction (IA), and Work Addiction (WA). The South Oaks Gambling Screen-Revised Adolescent, the Compulsive Buying Scale, the Exercise Addiction Inventory, the Internet Addiction Test, and the Work Addiction Risk Test, were compiled anonymously by the students.ResultsOverall prevalence was 7.0% for PG, 11.3% for CB, 1.2% for IA, 7.6% for WA, 8.5% for EA. PG, and EA were more common among boys, while gender had no effect on the other conditions. CB was more common among younger (< 18 years old) students. Each of these conditions showed a strong association with others, and the scores of all of these scales were correlated.DiscussionIn line with previous studies our results indicate that behavioural addictions are quite common among adolescents. The strong association between behavioural addictions stresses the concept that treatment for one of these conditions should involve assessment and treatment for the others.
PW01-69 - Post-Infarct Depression In A General Hospital: Diagnosis And Therapy
Authors: Istikoglou C. , Vlissides D. , Foutsitzis D. , Papouli F. , Polonifis N. , Kanellos P. , Kogeorgos J. , Salla T. 
Published: June 2010

ObjectivesPost-infarct Depression appears to 15-30% of the patients treated in the Infarction Units, according to the International Standards. It appears 24-72 hours following an Acute Infarction of the Myocardium.MethodsWe studied 300 patients treated in the Infraction Treatment Unit for a period of three months, within the framework of a Liaison Consultation Psychiatry program. 180 patients were men (60%) and 120 patients were women (40%). The average age of male patients was 52 years and the average age of female patients was 58 years. These patients were submitted to the Montgomery-Arnsberg Depression Rating Scale (MADRS) to evaluate Depression. According to the results of the Scale, these 120 patients presented depressive symptomatology, 45 patients presented mild symptomatology, 70 patients presented average symptomatology, and 5 patients presented heavy symptomatology.ResultsAll the above patients were treated with SSRIs. In particular, they received Fluoxetin, Sitalopram, Esitalopram, Fluvoxamine, Sertraline. The MADRS Scale has been evaluated on 15 days, 1, 2, 3, and 6 months following the initiation of therapy. 110 patients (91%) presented a significant reduction of MADRS Scale, while 10 patients (9%) showed resistance to the treatment and had to switch their treatment scheme with SNRIS or NASSAS.ConclusionsThe SSRIs constitute the most advisable treatment for post-infraction depression, due to their low side-effect profile. The rate of positive outcome for post-infarction depression treatment was especially high (91%) during treatment with SSRIs at a level consistent with the international literature reference.
PW01-80 - The Effects On The Level Of Intestinal Endotoxemia In Alzheimer Disease Rats
Authors: Han D. , Wang F. 
Published: June 2010

AimThe objective of the study was to explore whether IETM participate in the development of Alzheimer disease's rats which were established by D-galactose and aluminum trichloride (AlCl3).MethodsAdult Wistar rats were subjected to 90 days of intraperitoneal injection with D-galactose and AlCl3 to establish the Alzheimer disease's model. After the administration, the study and memory ability of the Alzheimer disease's rats were observed by Morris water maze; The level of Lipopolysaccharide (LPS) in the sera of Alzheimer disease's rats was determined by tachypleus amebocyte lysate method; The level of tumor necrosis factor-α (TNF-α) and interleukin-1 (IL-1) in the sera of Alzheimer disease's rats were determined by radioimmunity method; The express of amyloid β-protein precursor (APP), presenilin 1 (PS1) and β-site APP-cleaving enzyme (BACE) in hippocampus of Alzheimer disease's rats were detected by RT-PCR.ResultsCompared with the normal control, the level of LPS in the sera and the express of APP, PSI, BACE mRNA in the hippocampus of Alzheimer disease's rats were markedly increased (P< 0.01).ConclusionsThe model of Alzheimer disease's rats which were established by D-galactose and AlCl3 is accompanied IETM. This result suggests that IETM play an important role in the development of Alzheimer disease.
PW01-85 - Atrial Fibrillation And The Risk For Conversion From Mild Cognitive Impairment To Dementia In Subjects Aged Over 65
Authors: Podea D.M. , Chenderes R.M. , Nanu P.D. , Mila C. 
Published: June 2010

BackgroundMild cognitive impairment (MCI) may be considered a pre-dementia cognitive state. The turn fromMCI to dementia is not clearly understood.It appears to be determined by the vascular risk factors of each individual.PurposeTo determine if atrial fibrillation (AF) is a risk factor for conversion from MCI to dementia in an elderly population subgroup with certifiedMCI (MMSEscore: 28-21).Material and methodThere were included 123 subjects with MCI, aged over 65. They were evaluated yearly for 2 years using the Mini Mental State Examination(MMSE), ECG, CT scan and medical history.ResultsThe average age was 72.8+/4.3 yrs,with a sex ration male to female 1.27:1. Of the123 subjects17.07% (n=21) had AF at admission. The average MMSE difference was 2.3 points between the two cohorts in favor for the non-AF subjects(n=102). At1year, theAF cohort increased to 28 subjects and at two years to 33. The MMSE scores remain lower in AF cohort with an average of 7.4 points on the scale (p< 0.001,CI95%) at 2 years. In the AF cohort 75.75% (n=25) of the subjects had certified dementia by the end of the study, while in non-AF group only 12.2% (n=12)conversed to dementia with a clear statistical difference between the two groups (p< 0.001, CI95%). When other vascular risk factors were considered the strongest correlations were associated with cerebral stroke (p=0.002, CI95%), hypertension (p=0.012, CI95%) and dyslipidemia (p=0.023, CI95%). The longest the time-span from the MCI onset positively correlated to MCI-dementia conversion in both cohorts (p< 0.001, CI95%).DiscussionsMCI is regarded as a precursor of dementia, but not all patients with MCIactually develop dementia. Alzheimer and vascular dementia share several pathogenic mechanisms and the involvement of vascular risk factors is determinant in the clinical course.ConclusionAtrial fibrillation may predict the conversion from MCI to dementia,but other vascular risk factors may concur to it.The time-span from MCI onset is an independent risk factor for conversion to dementia in MCI elderly subjects with a direct relation.
PW01-88 - Visualization And Quantification Of App Intracellular Domain (Aicd) Mediated Nuclear Signaling By Bimolecular Fluorescence Complementation
Authors: Riese F. , Goodger Z. , Kallinna K. , Konietzko U. 
Published: June 2010

Although several targets of APP intracellular domain (AICD) mediated transcriptional gene regulation have been published, the role of AICD in nuclear signaling in health and (Alzheimer's) disease remains under debate. We previously demonstrated that AICD forms nuclear complexes with two other proteins, Fe65 and Tip60, called AFT complexes. Functionally, these co-localization areas likely represent sites of transcription. However, it is currently unknown how the formation of these complexes is regulated.Bimolecular fluorescence complementation (BiFC) is a recently developped technique to visualize protein/protein interaction. We established a detection system based on BIFC to study the intracellular interaction of AICD, Fe65 and Tip60 in cell culture. By means of confocal microscopy the subcellular localization of the proteins was studied. The influence of several genetic mutations for familial Alzheimer's disease as well as for caspase cleavage and phosphorylation sites was quantified by fluorescence assisted cell sorting (FACS).Using our BiFC visualization system, we could verify known findings such as APP/APP dimerization in the membrane and the interaction of AICD, Fe65 and Tip60 in the nucleus. Our system furthermore revealed the regulatory effect of familial AD and caspase cleavage site mutations on AFT complex formation.AFT complex formation can be effectively visualized and quantified by means of our novel BiFC constructs, thus opening new insights into the functions of the amyloid precursor protein APP.
PW01-89 - Symtoms Of Dementia With Lewy Bodies Cluster In Persons With Mild Dementia
Authors: Rongve A. , Brønnick K. , Ballard C. , Aarsland D. 
Published: June 2010

ObjectivesTo explore the inter-relationship between the core and suggestive symptoms of Dementia with Lewy Bodies (DLB) and the cognitive profiles in persons with newly diagnosed mild dementia.Method139 persons with mild dementia were recruited from dementia clinics in Western Norway. Symptoms were rated using standardized instruments. A two-step cluster analysis was applied to classify persons into groups according to scores on scales for hallucinations, parkinsonism, fluctuations and REM sleep behavior disorder (RBD).ResultsFour distinct clusters were revealed: A “Lewy Body Dementia” (LBD) cluster with high scores for both hallucinations, parkinsonism and fluctuation, and a “non-LBD” cluster with low scores on all DLB symptom scales were identified. In addition, two clusters with high scores on either RBD or cognitive fluctuation scales emerged. Persons in the LBD cluster had lower scores for visuospatial cognitive abilities as compared to the non-LBD group.(p=.002)ConclusionWith a cluster analysis we provide empirical support for the existence of a distinct subgroup in mild dementia with high scores on scales for hallucinations, parkinsonism and cognitive fluctuations and a distinct cognitive profile, i.e. supporting the clinical diagnosis DLB.
PW01-91 - Italian Elderly Admitted To An Acute Psychiatric Unit: A Case-Control Study
Authors: Tomassi S. , Bonafede R. , Moretti F. , Pedrini E. , De Ronchi D. , Atti A.R. 
Published: June 2010

ObjectivesEven if medical and psychiatric co-morbidity often overlap, specific combined medical-psychiatric units do not exist in Italy and elderly who need urgent psychiatric care are usually admitted in the Acute Psychiatry Unit of general hospitals despite many difficulties. The aim of this study is to describe this phenomenon.Methods55 cases (>65 years) and 120 randomly selected controls (30-60 years), were picked-up among all patients hospitalized between 1st January-31st December 2008. Socio-demographic and clinical information were collected through the retrospective consultation of the case histories of all participants.ResultsCases were significantly different from controls in terms of psychiatric background, medical history and medical pharmacotherapy: mood disorders (38.2%) and positive medical histories (81.8%) prevailed among elderly as compared to adult controls (p< 0.001; p< 0.001 respectively). The use of drugs (other than psychotropic ones) was four-fold more frequent in the elderly (74.5% vs 16.6%; p< 0.001). Cases and controls used differently the service: elderly requiring more frequently medical pharmacotherapy (81.8% vs 27.5%; p< 0.001), specialist consults (38.2% vs 11.6%; p< 0.001), laboratory tests (76.4% vs 60%; p=0.04) and instrumental tests (chest radiography 9% vs 0.8%; p=0.01; brain neuroimaging 12.7% vs 2.5%; p=0.01).The multi-adjusted logistic regression analysis confirmed a different pattern of use of the acute psychiatric service for elderly as compared to adult controls.ConclusionsElderly have peculiar medical histories and distinguishing management needs, notably in the medical field. Our data suggested the need of a new clinical approach concerning combined psychiatric-medical inpatient acute units in Italy.
PW01-96 - False Diagnosis Of Mental Retardation: Wisc Iii Test'S Place In A Child Psychiatry Service
Authors: Pegoraro L.F.L. , Santos A. , Salán T.M. , Jacintho A.C.d.Á. , Celeri E.H.R.V. , Dalgalarrondo P. ,   Child and Adolescent Psychiatry Study Group
Published: June 2010

ObjectivesTo access the Intelligence Wechsler Scale for Children (WISC-III) as an auxiliary resource in the diagnosis of patients with suspected mental retardation.MethodsThirty patients were evaluated in a university psychiatric service for children and adolescents, consulted during 2008. Those patients underwent a psychiatric evaluation and, after, subsequently the WISC III scale was administered. Patients were classified, according to their intellectual coefficients, as with or without a mental retardation score, following ICD-10 criteria. The results were transferred to a SPSS (Statistical Package for Social Sciences) spreadsheet and then analyzed in its socio-demographic and clinic variables.ResultsOf the thirty patients, 18 (60%) were children and 12 (40%) adolescents; 22 (73,33%) were male and 8 (26,67%) female. Furthermore, the sample revealed that 20 (68,97%) patients had had an axis I diagnosis. For the participants, 7 (23,3%) had an IQ below the cutoff of 70, consistent with the mental retardation diagnosis, and agreeing with the psychiatric evaluation. The other 23 (76,7%) patients had an IQ within the normal range. From those considered intellectually deficient, 5 (71,43%) had a score for mild and 2 (28,57%) for moderate mental retardation.ConclusionsThis study showed that clinical diagnosis of mental retardation is difficult, especially for mild cases, when the characteristics are not very clear. The error probability is increased if an instrument such as WISC III is not administered. Therefore, WISC III is an important instrument in the diagnostic process for mental retardation, in many instances changing a first clinic impression.
PW01-101 - From Diagnosis To Treatment - An Analysis Of Access To Depression-Specific Outpatient Treatment For Patients With Depression
Authors: Bönisch S. , Mergl R. , Matschinger H. , Wimmer-Brunauer C. , Tauscher M. , Kramer D. , Hegerl U. , Bramesfeld A. , Kocalevent R.-D. 
Published: June 2010

BackgroundFormer studies show low treatment rates of outpatients with a diagnosis of depression. The aims of this study are to examine(1)the rate of diagnosed depression in outpatient care,(2)rates of treatment of depression according to individual and regional characteristics and(3)effects of individual and regional characteristics on getting depression-specific treatment in the federal state of Bavaria.MethodsPrevalence of depression and outpatient treatment for depression as well as individual and regional characteristics of outpatients diagnosed with depression were analysed based on secondary data from the Association of Statutory Health Insurance Physicians Bavaria in 2006 (N=780,226). Descriptive analyses were followed by logistic regression analysis (STATA, PASW) to examine predictive effects of individual and regional characteristics on getting depression-specific treatment.ResultsPrevalence of diagnosed depression is 9.2% for persons who are statutory health insured and older than 17 years. 55% of diagnosed depressed patients do not get a depression-specific treatment within one year. Rates of a depression-specific treatment are higher for persons who are female, of middle age, with a moderate or severe depression, with a psychiatric comorbidity, without somatic comorbidity, who live in more rural areas.ConclusionsThe access to depression-specific treatment after a diagnosis of depression must be facilitated. Training for physicians, psychoeducation for patients and anti-stigma campaigns are necessary measures to reach this goal. The knowledge about influence of individual characteristics on getting a depression-specific treatment is important to reach the groups who get least depression-specific treatment.
PW01-104 - Factors Associated to Use of Ambulatory Public Mental Health Services A Patients With Schizophrenia in Spain. Case Register Study: Resma
Authors: Moreno-Küstner B. , Navas-Campaña D. , Mayoral F. , Angona P. , García-Herrera J.M. , Moreno-Peral P. , Pérez O. 
Published: June 2010

ObjectiveTo identify factors associated with visits by patients with schizophrenia and related disorders to community mental health services, under the Mental Health Department of Carlos Haya Hospital in Malaga, Spain.MethodsWe undertook a cross-sectional study. Data on demographic and clinical factors and service use were obtained from the public mental health services database and centralized in the “Malaga Schizophrenia Case Register (RESMA)”. The outcome measure, defined as the total number of outpatient consultations during one year, was analyzed by multilevel multivariate linear regression.ResultsThe analysis included 1097 patients with diagnoses of schizophrenia and related disorders (F20-F29, ICD-10).The adjusted model explained 46.35% of the variance. Patients who contacted both types of professional (nurses and psychiatrists) had a higher number of visits compared to patients who only contacted a psychiatrist (p< 0.001), and the individual psychiatrist attending the patients was also associated with the number of visits (p< 0.001).Clinical variables, such as a higher global level of severity (p< 0.001), a diagnosis of a persistent delusion disorder and having an inpatient episode (p< 0.001), were also associated with a higher number of visits. Patients who were receiving welfare benefits or who had no formal education or were illiterate had a higher number of visits. Patients living alone, living outside the study area and living in more rural municipalities was associated with fewer ambulatory contacts.ConclusionAmong all variables, the role of psychiatrists and nurses in organized outpatient settings present the strongest association with the number of visits by similar patients.
PW01-109 - Epidemiology And Characteristics Of Suicidal Behaviour In General Population In Slovenia
Authors: Roskar S. , Kamin T. , Jericek Klanscek H. , Zorko M. , Bajt M. 
Published: June 2010

ObjectivesTo study and to evaluate the mental health of the general population of Slovenia with a special emphasis on suicidal behaviour.MethodsThe representative sample consisted of 846 randomly selected adult Slovene inhabitants, chosen from a pool of telephone subscribers (N = 2433). Data were gathered by the means of a telephone interview using standardised measures (RSES, Questionnaire of social support, Sense of Mastery) on specific variables related to mental health and suicidal behaviour, e.g. presence of mental illness, use of psychotropic substances, self esteem, sense of mastery of life, social support, etc.Results10% of participants have had suicidal ideation, 2% have had a plan for a suicide attempt (in both cases statistically significantly more women) whereas only 1% of the respondents actually attempted suicide. Greater risk for suicide was found among divorced and single persons and those living in rural areas. More than half of suicidal individuals didn’t seek help for their problems anywhere and those who did, mostly turned to relatives and friends. We observed statistically significant differences in help seeking among men and women (the later asking for help more). Suicidal individuals reported of statistically significant smaller social network, of smaller emotional support, lower self-esteem and lower feelings of having control over their own lives when compared to non-suicidal individuals.ConclusionOur results accord with specific theories of risk factors (sociological, psychological, etc.) and bear potential for directions to be taken when tailoring suicide prevention strategies, in particular when addressing the general population.
PW01-112 - Prevalence Of Adhd In School Children In Athens. Association Of Adhd Subtypes With Clinical Impairment
Authors: Skounti M. , Philalithis A. , Giannoukas S. , Dimitriou E. , Nikolopoulou S. 
Published: June 2010

ObjectivesThe aim of this study was to explore the prevalence of Attention Deficit Hyperactivity Disorder (ADHD) and social and academic impairment in 6-11 year-old children residents of Athens, Greece.MethodsFollowing the DSM-IV diagnostic criteria, the study combined information from teachers for 603 elementary school children following grades first to sixth. A 2-stage screening process was employed including the standardized ADHD test and the Teacher Report Form (TRF).ResultsAmong 603 children, 36 (6.0%) met the study criteria for ADHD. The estimated prevalence was 8% for boys and 3.8% for girls (p=0.028). The most prevalent subtype of ADHD was the Combined type (3.8%), followed by ADHD- Inattentive (1.7%) and Hyperactive-Impulsive type (0,5%). Gender differences were observed in the prevalence of ADHD-Combined subtypes (p=0.003). Statistical significant differences were observed between ADHD subtypes and gender (p=0.047). ADHD-Combined type was associated with greater impairment in both academic and social domains, where ADHD-Inattentive subtype showed a higher academic, but lower social impairment. The ADHD-Hyperactive-impulsive children were not significantly impaired in their academic functioning, while social functioning resulted moderately impaired.ConclusionsThe prevalence of ADHD among schoolchildren in Athens and the risk factors are comparable to those reported in several epidemiological studies worldwide. Impairment in social and academic functioning seems to be strongly associated with the subtype of ADHD. Further research into the association between ADHD symptoms and impairment is warrant.