bluuebunny/crossref_metadata_2025_split huggingface dataset:
Middle aortic syndrome with renal involvement: A staged strategy to manage systemic hypertension
Authors: Morgan Gareth , Benson Lee , Geary Denis 
Published: July 2011

AbstractLong segment narrowing of the thoracoabdominal aorta or so‐called middle aortic syndrome (MAS), is an uncommon lesion presenting variably with physical signs of coarctation of the aorta, hypertension, renal insufficiency and or mesenteric ischemia. The etiologies are multiple, but Takayasu's arteritis is a leading cause. Variable involvement of diverse systemic arterial systems requires individualized management strategies. We report a case of a successful treatment algorithm for severe MAS using a strategy of percutaneous aortic endovascular stent implantation to rebuild the distal aorta and renal auto‐implantation to address systemic hypertension. © 2011 Wiley Periodicals, Inc.
Retroperitoneal hemorrhage after percutaneous coronary intervention in the current practice era: Clinical outcomes and prognostic value of abdominal/pelvic computed tomography
Authors: Maluenda Gabriel , Mitulescu Lavinia , Ben‐Dor Itsik , A. Gaglia Michael , Weissman Gaby , Torguson Rebecca , F. Satler Lowell , Pichard Augusto D. , Bernardo Nelson L. , Waksman Ron 
Published: July 2011

AbstractBackground: Retroperitoneal hemorrhage (RPH) is a serious but infrequent complication of percutaneous coronary intervention (PCI). This study aimed to describe the clinical outcomes of patients who developed RPH following PCI in the current practice era, with particular focus on treatment strategies and the related prognostic value of abdominal/pelvic computed tomography (CT). Methods: Among 20,904 patients undergoing PCI, we identified 93 RPH (0.45%) confirmed by CT or by unequivocal surgical findings. We identified three groups with RPH for comparison: patients who developed refractory shock (systolic blood pressure <80 mm Hg for ≥30 min despite fluids and vasopressors, n = 16 [17.2%]); patients with transient hypotension (<30 min, n = 34 [36.6%]); and patients without hypotension (n = 43 [46.2%]). The primary endpoint was a composite of in‐hospital mortality, myocardial infarction, and cerebral vascular accident (CVA). Results: Baseline clinical, angiographic, and procedural characteristics were similar among the three groups. Patients who developed refractory shock had significantly more bleeding quantified by abdominal/pelvic CT (P < 0.001), had a higher rate and amount of red blood cell transfusion (P < 0.001), and were managed invasively more frequently (68.7%) than the rest of the population. The primary endpoint trended higher in patients presenting with refractory shock; however, this difference was not statistically significant. The volume of bleeding quantified by CT and the timing of imaging diagnosis did not correlate with the primary endpoint. Red blood cell transfusion, but not clopidogrel discontinuation, was associated with the primary endpoint. Conclusions: RPH remains as a serious complication of PCI and is associated with high rates of mortality and morbidity independently of the therapeutic strategy. In patients who were hemodynamically stable, RPH volume as quantified by non‐contrast abdominal/pelvic CT did not contribute to prognosis. © 2011 Wiley Periodicals, Inc.
Incomplete arterial healing 8 years after the implantation of sirolimus‐eluting stent. In vivo visualization by optical coherence tomography
Authors: Bouki Konstantina P. , Sakkali Eleni K. , Apostolou Thomas S. 
Published: July 2011

AbstractThe time course of complete arterial healing after drug eluting stent implantation is unknown. We present a case of incomplete endothelialization and late stent malapposition identified by optical coherence tomography 8 years after a sirolimus‐eluting stent implantation, which was not related with any adverse clinical event. © 2011 Wiley Periodicals, Inc.
Pseudoaneurysm after transradial cardiac catheterization: Case series and review of the literature
Authors: Collins Nicholas , Wainstein Rodrigo , Ward Michael , Bhagwandeen Rohan , Dzavik Vladimir 
Published: July 2011

AbstractIntroduction: Radial artery access for diagnostic and therapeutic procedures offers clear advantages in terms of vascular complications. While radial artery occlusion may occasionally complicate radial artery access, new methods of hemostasis are now utilized to avoid this complication. In contrast, pseudoaneurysm following radial artery access is an extremely uncommon complication. Methods: We describe a series of patients who developed radial artery pseudoaneurysm after their procedure. Results: Five patients developed radial pseudoaneurysm after diagnostic and interventional procedures, likely reflecting inadequate hemostasis following the procedure and delayed bleeding complicating systemic anticoagulation. Conclusions: While uncommon, radial artery pseudoaneurysm may complicate cardiac catheterization procedures, with anticoagulation an important contributor. The clinical presentation, likely precipitating mechanisms and treatment options are discussed. © 2011 Wiley Periodicals, Inc.
Quality improvement in the door‐to‐balloon times for ST‐elevation myocardial infarction patients presenting without chest pain
Authors: Borden William B. , Fennessy Michelle M. , O'Connor Anne M. , Mulliken Robert A. , Lee Linda , Nathan Sandeep , Nichols Jearlyn , Lopez John J. 
Published: July 2011

AbstractObjective: To assess a quality improvement initiative aimed at minimizing door‐to‐balloon (DTB) times for ST‐elevation myocardial infarction (STEMI) patients presenting without chest pain. Background: Timely percutaneous coronary intervention (PCI) is the cornerstone of STEMI care. The absence of chest pain delays PCI. Improvements in DTB times may need to focus on atypical presentation patients. Methods: We compared DTB times on all STEMI patients admitted through the emergency department who underwent PCI before (Phase I; October 2004–June 2007) and after (Phase II; July 2007–October 2009) the quality improvement effort, which mandated rapid electrocardiogram (ECG) triage for an expanded list of presenting symptoms. Results: In Phase I (69 patient, 60 with chest pain), patients with chest pain had a shorter mean time to first ECG (ECG Interval) by 32.0 min (P < 0.01) and nonsignificantly faster mean DTB time by 42.0 min (P = 0.07) compared to patients who presented without chest pain. In Phase II (62 patients, 56 with chest pain) compared to Phase I, mean ECG interval decreased by 44 min (P = 0.02) and mean DTB time by 99 min (P = 0.01) in patients without chest pain, eliminating the differences in ECG intervals between typical and atypical presentations (12 min vs. 11 min, P = 0.91). Multivariable analysis controlling for on/off hours and patient characteristics confirmed these findings. Conclusions: A simple modification of emergency room ECG triage protocol, which expands indications for rapid ECG performance, was successful in improving rapid reperfusion for patients with STEMI presenting without chest pain. © 2011 Wiley‐Liss, Inc.
Reduced antiplatelet therapy after drug‐eluting stenting: Multicenter janus flex carbostent implantation with short dual antiplatelet treatment for 2 or 6 months—matrix study
Authors: Cassese Salvatore , De Luca Giuseppe , Villari Bruno , Berti Sergio , Bellone Pietro , Alfieri Alfonso , Montinaro Antonio , Quaranta Gaetano , Marraccini Paolo , Piscione Federico ,   on behalf of MATRIX Study Investigators
Published: July 2011

AbstractObjectives: The Multicentre registry with Antiplatelet TReatment two–sIX months (MATRIX) evaluated safety and efficacy at 12‐month follow‐up of Janus Flex stenting with 2‐ or 6‐month dual antiplatelet therapy (DAT) period. Background: There are no data of Janus Flex stent (Carbostent and Implantable Devices—CID, Saluggia, Italy), a polymer‐free, tacrolimus‐eluting coronary stent, followed by short‐term DAT, in daily practice. Methods: Patients were prospectively enrolled at 12 high‐volume procedures centres. After stenting, four sites prescribed 2‐month DAT, eight sites 6‐month DAT. Major adverse cardiac events (MACE) and stent thrombosis (ST) rate was evaluated at 12‐month follow‐up, for entire population, as well as for 2‐ and 6‐month DAT groups, distinctly. MACE included cardiac death, myocardial infarction (MI), and target lesion revascularization (TLR). Results: From March 2007 to June 2008, 572 patients (mean age 64.91 ± 11 years, 77.45% males) were enrolled. After successful stenting, 12‐month follow‐up showed a 12.74% MACE occurrence (cardiac death 0.98%; MI 3.13%; TLR 8.62%), with good Janus Flex safety profile confirmed by only two (0.39%) ST. After adjustment for potential confounding, no significant differences were noted at 12‐month follow‐up among 2‐ or 6‐month DAT groups (MACE—8.99% versus 12.47%, P = 0.16; cardiac death—0.54% versus 1.14%, P = 0.52; MI—2.38% versus 2.71%, P = 0.83; TLR—5.66% versus 10.60%, P = 0.20; ST—0% versus 0.55%, P = 0.99). At multivariable analysis, DAT time duration was not an independent risk factor for adverse events (adjusted HR 0.47, 95% confidence interval 0.16–1.35, P = 0.16). Conclusions: Janus Flex coronary stenting, followed by short DAT, is safe and feasible, without differences between 2‐ and 6‐month DAT groups. A randomized trial confirming these encouraging data is needed. © 2011 Wiley Periodicals, Inc.
Percutaneous left main coronary disease treatment without on‐site surgery back‐up in patients with acute coronary syndromes
Authors: Gagnor Andrea , Tomassini Francesco , Romagnoli Enrico , Infantino Vincenzo , Rosa Brusin Maria Cristina , Maria Cristina , Tripodi Rosario , Sangiorgi Giuseppe , Varbella Ferdinando 
Published: July 2011

AbstractBackground: Best revascularization strategy in patients with acute coronary syndromes (ACS) and unprotected left main (ULM) coronary disease is still debate reflecting lack of convincing data. Objectives: To assess clinical feasibility and efficacy of ULM percutaneous coronary intervention (PCI) in patients with ACS and describe the practice of a center without on‐site surgical back‐up over a 7‐year period. Methods: Data on high‐risk patients with ACSs undergoing percutaneous ULM treatment were prospectively collected in an independent registry. Primary end‐points of this study were immediate and long‐term outcomes expressed as target lesion failure (TLF, composite of cardiac death, myocardial infarction (MI), and target lesion revascularization). Results: Between January 2003 and January 2010, 200 consecutive patients were included in this study. Angiographic success was obtained in 95% of patients but procedural success was 87% primarily affected by an 11% of in‐hospital cardiac mortality. At median follow‐up of 26 months (IQ 10–47), the overall TLF rate was 28.5%, with 16.0% of cardiac death, 7.0% of MI, and 10.5% of clinically driven target lesion revascularization rates. Cumulative definite/probable stent thrombosis was 3.5%. Elevated EuroSCORE value and pre‐procedural hemodynamic instability were the strongest predictors of TLF. Temporal trend analysis showed progressive but not significant improvement for both immediate (P = 0.110) and long‐term (P = 0.073) outcomes over the study period. Conclusions: This single‐center study based on current clinical practice in patient with ULM disease and ACS confirmed PCI as feasible revascularization strategy in absence of on‐site cardio‐thoracic support. Nevertheless, the outcome of these high‐risk patients is still hampered by a sensible in‐hospital mortality rate. © 2011 Wiley Periodicals, Inc.
Lack of long‐term clinical benefit of thrombus aspiration during primary percutaneous coronary intervention with paclitaxel‐eluting stents or bare‐metal stents: Post‐hoc analysis of the PASSION‐trial
Authors: Vink Maarten A. , Dirksen Maurits T. , Tijssen Jan G.P. , Suttorp Maarten J. , Patterson Mark S. , van Geloven Nan , Ijsselmuiden Alexander J. , Slagboom Ton , Kiemeneij Ferdinand , Laarman Gerrit J. 
Published: July 2011

AbstractBackground: Although current clinical guidelines recommend the use of thrombus aspiration (TA) during primary percutaneous coronary intervention (PPCI), previous studies evaluating TA demonstrated contradictory results. The aim of this study was to evaluate long‐term clinical outcome after TA in adjunct to PPCI for acute ST‐segment myocardial infarction (STEMI), as compared with conventional treatment, with the use of paclitaxel‐eluting stents or bare‐metal stents. Methods: We analyzed data of the PASSION trial, in which 619 patients with STEMI were randomly assigned to a paclitaxel‐eluting stent or a bare‐metal stent. TA was performed in 311 patients (50.2%). Clinical endpoints at 2 years were compared between patients who received TA during PPCI with patients who underwent conventional PPCI. The primary outcome of interest was a composite of cardiac death, recurrent myocardial infarction (MI), or target‐lesion revascularization (TLR). A propensity score model was made to account for baseline differences that could have affected the probability of performing TA. Results: Complete follow‐up was available for 598 patients (96.6%). The cumulative incidence of the combined outcome measure of cardiac death, recurrent MI, or TLR was 40 (13.0%) in the TA group and 41 (13.5%) in the conventional PPCI group (HR 0.96; 95% CI 0.62–1.47; P = 0.84). Also after adjusting for propensity score, no significant difference in event rate was observed between both treatment groups. Conclusions: In this post‐hoc analysis of the PASSION trial, TA in adjunct to PPCI did not affect rates of major adverse cardiac events at 2 years follow‐up, as compared with conventional PPCI. © 2011 Wiley Periodicals, Inc.
Transcatheter aortic valve implantation when classical access routes are unavailable
Authors: Mouillet Gauthier , Desgranges Pascal , Teiger Emmanuel 
Published: July 2011

AbstractA 90‐year‐old woman with symptomatic degenerative aortic stenosis had a logistic Euroscore greater than 53.29%, indicating a high surgical risk. She was therefore advised to undergo transcatheter aortic valve implantation. Both iliac arteries showed subocclusive calcifications, and the left subclavian artery was narrow and calcified. The left common carotid (LCC) artery was chosen as the access route. After surgical exposure of the LCC artery, the Corevalve Revalving 29‐mm bioprosthesis was implanted successfully. No access‐site complications occurred. In our experience, a substantial proportion of elderly patients have vascular lesions precluding use of the femoral route. Brachiocephalic access routes may be valuable when no other options are available. © 2011 Wiley Periodicals, Inc.
Treatment of a degenerative stenosed CoreValve® aortic bioprosthesis by transcatheter valve‐in‐valve insertion
Authors: Hammerstingl Christoph , Nickenig Georg , Grube Eberhard 
Published: July 2011

AbstractBackground: Transcatheter aortic valve insertion (TAVI) is an emerging therapy in patients at high risk for open heart surgery. The long‐term durability of the bioprosthesis is unknown. This is the first report of a severely degeneratively stenosed 2nd generation 26 mm CoreValve® aortic bioprosthesis which occurred five and a half years after TAVI. Methods and Results: A 92‐year‐old patient presented with decompensated heart failure NYHA class IV, pulmonary edema, and severe pulmonary hypertension. Echocardiography revealed critical AV‐stenosis due to heavily calcified bioprosthetic valve leaflets. Due to high surgical risk with an EuroSCORE of 64.97% and a STS‐mortality score of 27.0%, we decided to attempt a valve‐in‐valve insertion of a 3rd generation CoreValve® prosthesis of the same size. Following the delicate retrograde passage of the calcified valve with a preformed stiff wire, balloon valvuloplasty of the severely stenosed CoreValve® prosthesis under rapid right ventricular pacing was complicated by two balloon catheter ruptures. Insertion of the 3rd generation CoreValve® prosthesis of the same size was quite complex but finally it was successfully completed. There was mild periprosthetic regurgitation and significant decrease in transaortic pressure without residual transvalvular gradient immediately after TAVI. Echocardiography and clinical follow‐up at 72 hr after TAVI confirmed excellent valve function with a decrease in systolic pulmonary artery pressure from 70 mm Hg to 35 mm Hg, increase in LV‐EF from 35% to 45%, and improvement of functional status from NYHA IV to NYHA II. The patient was discharged in good medical conditions at day eight. Conclusion: Degenerative stenosis of a CoreValve® bioprothesis may be observed during long‐term follow‐up after successful TAVI for the treatment of severe aortic valve stenosis. A second valve‐in‐valve insertion appears feasible but may require particular interventional approaches. © 2011 Wiley Periodicals, Inc.
3‐D guidance of complex pulmonary artery stent placement using reconstructed rotational angiography with live overlay
Authors: Fagan Thomas , Kay Joseph , Carroll John , Neubauer Anne 
Published: July 2011

AbstractTechnologies which allow rotational angiographic image acquisition and three dimensional (3‐D) vascular reconstruction with subsequent fluoroscopic registration for live 3‐D image overlay are rapidly being adopted. We present the first use of rotational angiography with integrated 3‐D image overlay for guidance during complex pulmonary artery stent placement. Technical considerations, advantages, and limitations of this procedural strategy are discussed. © 2011 Wiley Periodicals, Inc.
Excellent Correlation between Drug Release and Portal Size in Metalla‐Cage Drug‐Delivery Systems
Authors: Barry Nicolas P. E. , Zava Olivier , Dyson Paul J. , Therrien Bruno 
Published: July 2011

AbstractA series of large cationic hexanuclear metalla‐prisms, [Ru6(p‐iPrC6H4Me)6(tpt)2(donq)3]6+, [Ru6(p‐iPrC6H4Me)6(tpt)2(doaq)3]6+ and [Ru6(p‐iPrC6H4Me)6(tpt)2(dotq)3]6+, composed of p‐cymene–ruthenium building blocks bridged by OO∩OO ligands (donq=5,8‐dioxido‐1,4‐naphthoquinonato; doaq=5,8‐dioxido‐1,4‐anthraquinonato, dotq=6,11‐dioxido‐5,12‐naphthacenedionato) and connected by two 2,4,6‐tripyridin‐4‐yl‐1,3,5‐triazine (tpt) panels, which encapsulate the guest molecules 1‐(4,6‐dichloro‐1,3,5‐triazin‐2‐yl)pyrene and Pd(acac)2, have been prepared. The host–guest properties of these water‐soluble delivery systems were studied in solution by NMR and fluorescence spectroscopy, providing the stability constants (K) for these host–guest systems. Moreover, the ability of the hosts to deliver the guests into cancer cells was evaluated and the uptake mechanism studied; the rate of release of the guest molecule was found to depend on the portal size of the host.
Selective Photocatalytic Oxidation of Alcohols to Aldehydes in Water by TiO2 Partially Coated with WO3
Authors: Tsukamoto Daijiro , Ikeda Makoto , Shiraishi Yasuhiro , Hara Takayoshi , Ichikuni Nobuyuki , Tanaka Shunsuke , Hirai Takayuki 
Published: July 2011

AbstractSemiconductor TiO2 particles loaded with WO3 (WO3/TiO2), synthesized by impregnation of tungstic acid followed by calcination, were used for photocatalytic oxidation of alcohols in water with molecular oxygen under irradiation at λ>350 nm. The WO3/TiO2 catalysts promote selective oxidation of alcohols to aldehydes and show higher catalytic activity than pure TiO2. In particular, a catalyst loading 7.6 wt % WO3 led to higher aldehyde selectivity than previously reported photocatalytic systems. The high aldehyde selectivity arises because subsequent photocatalytic decomposition of the formed aldehyde is suppressed on the catalyst. The TiO2 surface of the catalyst, which is active for oxidation, is partially coated by the WO3 layer, which leads to a decrease in the amount of formed aldehyde adsorbed on the TiO2 surface. This suppresses subsequent decomposition of the aldehyde on the TiO2 surface and results in high aldehyde selectivity. The WO3/TiO2 catalyst can selectively oxidize various aromatic alcohols and is reusable without loss of catalytic activity or selectivity.
The Role of Oxidative Etching in the Synthesis of Ultrathin Single‐Crystalline Au Nanowires
Authors: Kisner Alexandre , Heggen Marc , Fernández Enrique , Lenk Steffi , Mayer Dirk , Simon Ulrich , Offenhäusser Andreas , Mourzina Yulia 
Published: July 2011

AbstractThe fabrication of ultrathin single‐crystal Au nanowires with high aspect ratio and that are stable in air is challenging. Recently, a simple wet‐chemical approach using oleylamine has been reported for the synthesis of Au nanowires with micrometer length and 2 nm in diameter. Despite efforts to understand the mechanism of the reaction, an ultimate question about the role of oxygen (O2) during the synthesis remained unclear. Here we report that the synthesis of ultrathin Au nanowires employing oleylamine is strongly affected by the amount of O2 absorbed in the reaction solution. Saturating the solution with O2 leads to both a high‐yield production of nanowires and an increase in their length. Nanowires with diameters of about 2 nm and lengths of 8 μm, which corresponds to an aspect ratio of approximately 4000, were produced. The role of oxygen is attributed to the enhanced oxidation of twin defects on Au nanoparticles formed in the first stage of the reaction. Understanding the role of oxidative etching is crucial to significantly increasing the yield and the length of ultrathin Au nanowires.
A Highly Sensitive and Selective Fluorescent Probe for Cyanide Based on the Dissolution of Gold Nanoparticles and Its Application in Real Samples
Authors: Lou Xiaoding , Zhang Yi , Qin Jingui , Li Zhen 
Published: July 2011

AbstractWe report a simple fluorescence method for detection of cyanide sensitively and selectively based on the dissolution of polymer‐coated gold nanoparticles by cyanide. The lowest concentration for quantification of cyanide ions was 3.0×10−7 M, and other common anions nearly have no influence. Furthermore, several real water samples spiked with cyanide, including local groundwater, tap water, boiled water, and lake water, were analyzed, and the experimental results demonstrated that our sensing system worked well in the above water samples, with a good linear correlation.
Multicomponent Assembly of Cavitand‐Based Polyacylhydrazone Nanocapsules
Authors: Lin Zhihua , Emge Thomas J. , Warmuth Ralf 
Published: July 2011

AbstractThe thermodynamically controlled syntheses of different di‐, tetra‐, and hexacavitand polyacylhydrazone nanocapsules are reported. [2+4]‐, [4+8]‐, and [6+12]‐nanocapsules assemble upon reacting a tetraformyl cavitand with two equivalents of isophthalic dihydrazide, or terephthalic dihydrazide in the presence of trifluoroacetic acid, whereby the building blocks are linked together through 8, 16, or 24 newly formed acylhydrazone bonds. Futhermore, the reaction of the tetraformylcavitands with different trigonal planar trihydrazides, simultaneously leads to the formation of [2+4]‐ and [6+8]‐nanocapsules in varying ratios that depend on the cavitand to trihydrazide ratio and the nature of the cavitand and trihydrazide building blocks. The product ratios are rationalized with the different conformational strain of the acylhydrazone linkages in these nanocapsules. Diffusion NMR experiments with the hexacavitand polyacylhydrazone nanocapsules yield solvodynamic radii that range from 1.6 to 2.5 nm, consistent with estimates from force field calculations, and support, that these capsules have solvent filled, spherical interiors, the sizes of which approaches those of smaller proteins.