bluuebunny/crossref_metadata_2025_split huggingface dataset:
PENGARUH GREEN MARKETING DAN ENVIRONMENTAL KNOWLEDGE TERHADAP KEPUTUSAN PEMBELIAN PRODUK THE BODY SHOP DI KOTA PALEMBANG
Authors: Cia Valen 
Published: June 2024

Green marketing adalah strategi pemasaran produk dengan konsep ramah lingkungan, enviromental knowledge adalah pemahaman yang dimiliki seseorang tentang lingkungan Penelitian ini bertujuan untuk mengetahui pengaruh dari green marketing dsn enviromental knowledge terhadap keputusan pembelian porduk The Body Shop di kota Palembang. Penelitian ini merupakan penelitian kuantitatif dengan metode survey. Populasi penelitian ini adalah konsumen yang telah menggunakan produk the body shop lebih dari satu tahun. Teknik dalam pengambilan sampel ini menggunakan Purposive sampling. jumlah sampel yang digunakan dalam penelitian ini sebanyak 110 responden. Teknik analisis data untuk pengujian masing masing variabel menggunakan software SPSS 25. Hasil penelitian ini menunjukan bahwa green marketing berpengaruh positif terhadap keputusan pembelian. Sementara, enviromental knowledge berpengaruh negatif terhadap keputusan pembelian.
Necessidade de tratamento odontológico em pessoas com deficiência sob anestesia geral: Um estudo de coorte retrospectivo
Authors: Pacheco Valéria Bordallo , Baeder Fernando Martins , Corazza Paola Fernanda Leal , Motta Eduardo , Martini Keller De , Zaffalon Gabriela Traldi , Magalhães Jose Cassio de Almeida , Ferreira Ana Cristina Fernandes Maria , Santos Maria Teresa Botti Rodrigues dos 
Published: June 2024

Foi realizado um estudo de coorte retrospetivo como objetivo comparar a necessidade de tratamento odontológico, realizado sob anestesia geral (AG) em indivíduos com deficiência intelectual (DI), paralisia cerebral (PC), transtorno do espectro do autismo (TEA) ou síndrome de Down (SD) atendidos no serviço odontológico do Hospital São Julião, em Mato Grosso do Sul, Brasil. Foram coletados dados de 790 prontuários odontológicos de indivíduos de ambos os sexos com necessidades especiais de saúde (NES) entre 0 a 59 anos de idade, que realizaram tratamento sob anestesia geral (AG). Os pacientes foram avaliados, pelo prontuário os indivíduos foram divididos em quatro grupos: G1 (ID [n=321]); G2 (CP [n=285]); G3 (TEA [n=131]); e G4 (DS [n=53]). Procedimentos preventivos, restauradores e cirúrgicos foram realizados em centro cirúrgico; o estágio da doença cárie foi avaliado usando o instrumento Caries Assessment Spectrum and Treatment (i.e., CAST). O teste qui-quadrado e a análise de variância foram utilizados para as comparações, com nível de significância de 5%. Houve maior percentual de homens (p=0,0062) e de indivíduos entre 19 e 35 anos (p<0,0001). Os grupos diferiram significativamente (p<0,05) quanto à média de idade, sendo o G3 o mais jovem. Com relação ao instrumento CAST, os sujeitos do G1 e G2 apresentaram percentual significativamente maior do código 7 (p<0,01 [teste qui-quadrado]). Doze meses após o primeiro procedimento realizado sob AG, apenas 16,45% retornaram para uma segunda consulta. A necessidade de tratamento odontológico acumulou nos quatro grupos, com maior número de sujeitos diagnosticados com DI e PC (ou seja, G1 e G3, respetivamente).
Desempenho produtivo de cereais de inverno em sistema integrado com nogueira-pecã
Authors: Pasa Mateus da Silveira , Carlos Felipe Selau , Pasa Ezequiel Helbig , Saraiva Carem Rosane Coutinho , Abreu Thierley Vitoria , Kanomata Thomas , Rosa Júnior Horacy Fagundes da 
Published: June 2024

Os sistemas integrados de produção, como os agroflorestais, são importantes alternativas para otimizar o uso da terra, diversificar a produção e melhorar a rentabilidade das propriedades agrícolas, mas o seu sucesso depende de estudos para identificar as interações entre espécies mais adequadas. Este trabalho teve como objetivo, verificar o desempenho de cereais de inverno (trigo e centeio) para a produção de grãos em sistema de integração agroflorestal com nogueira-pecã (Carya illinoinensis). O experimento foi conduzido no município de Encruzilhada do Sul – RS, nos anos de 2022 e 2023. Foram utilizados as cultivares Tbio Trunfo (trigo) e BRS Serrano (centeio). O delineamento experimental utilizado foi de casualização por blocos, com 6 repetições. Foram avaliados parâmetros de crescimento da nogueira-pecã (diâmetro de tronco e altura) e de produtividade do trigo e centeio. A partir do que foi explorado, observou-se que as culturas de inverno comparadas com a testemunha proporcionaram um incremento significativo na área da seção transversal do tronco das nogueiras. Além disso, a cultura do trigo obteve maior produtividade do que a do centeio, nas condições avaliadas. Os resultados mostram que a produção de cereais de inverno em integração com a nogueira-pecã é possível e pode se tornar uma importante alternativa para diversificação das matrizes produtivas, ainda que estudos futuros sejam necessários para determinar as melhores cultivares e manejos para maximização dos resultados obtidos.
Preenchimento facial e toxina botulínica em paciente com paralisia de Bell: Relato de caso
Authors: Souza Kaisa Azevedo Pinheiro Abreu de , Carvalho Elcia Bravin de 
Published: June 2024

A paralisia de Bell é um distúrbio neurológico não progressivo do nervo facial, tratando-se de uma condição altamente debilitante, tanto em termos estéticos quanto funcionais e o tratamento com injeções de toxina botulínica, com ou sem terapia neuromuscular, juntamente com preenchedores, tem mostrado resultados promissores na restauração de características faciais normais. Diante das possibilidades do uso da toxina botulínica e do tratamento adicional com ácido hialurônico na estética facial e funcional, tem-se como objetivo apresentar um caso clínico desta aplicação para a correção da assimetria facial causada pela paralisia de Bell. Trata-se de um relato de paciente com 37 anos, mulher, apresentando paralisia hemifacial. Foram utilizados preenchedores de ácido hialurônico e toxina botulínica. Os resultados demonstraram acentuada melhora na simetria facial e, de acordo com a paciente, o tratamento lhe devolveu a autoestima e, consequentemente, sua qualidade de vida. Conclui-se que a utilização da toxina botulínica tipo A e do ácido hialurônico são muito seguros e eficazes, desde que realizados sob a orientação de um profissional treinado para o seu uso terapêutico e cosmético e as assimetrias ocasionadas pela paralisia de Bell podem ser tratadas de forma eficaz por estes métodos. Neste relato, foi possível observar uma significativa melhora na simetria, equilíbrio e função muscular da face da paciente, bem como nos aspectos psicossociais, contribuindo para uma melhor qualidade de vida e aumento da autoestima.
Talasemia falciforme beta cero y síndrome torácico agudo en paciente pediátrico: Reporte de caso
Authors: López Muñoz Diego Fernando , Grisales Domínguez Juan Esteban , Delgado Garcés Nicolás , Llanos Posso Valeria , Arellano Genoy Camilo , Ortiz Corrales Olga Patricia 
Published: June 2024

El objetivo de este artículo es reportar el caso de un paciente masculino de 5 años de edad diagnosticado con Talasemia Falciforme Beta Cero. Enfermedad hereditaria que afecta la hemoglobina de los glóbulos rojos, causando la formación de hemoglobina S (drepanocítica) y talasemia. La presencia de "cero" indica la ausencia de hemoglobina normal en la sangre. Esta condición conduce a la deformación de los glóbulos rojos en forma de hoz, dificultando su circulación en vasos sanguíneos, generando complicaciones, entre ellas, el síndrome torácico agudo. Es posible reconocer esta enfermedad poco frecuente por su presentación clínica y con la ayuda del laboratorio. En el paciente se estableció diagnóstico con base en los hallazgos clínicos como las imágenes diagnósticas, hemograma, extendido de sangre periférica y electroforesis de hemoglobina y posterior evaluación por parte del especialista em hematología pediátrica. La genética clínica es cada vez más relevante en la medicina actual, y es fundamental que los profesionales de atención primaria (AP) se familiaricen con sus conceptos. La correcta identificación de estos pacientes asegura un adecuado consejo genético y la implementación de controles clínicos regulares. Esto permite una intervención preventiva temprana y el abordaje de problemas de salud antes de que se desarrollen completamente.
Antifungal and antibiofilm effects of probiotic Lactobacillus salivarius, zinc nanoparticles, and zinc nanocomposites against Candida albicans from Nile tilapia (Oreochromis niloticus), water and humans
Authors: El-Gazzar Nashwa , Elez Rasha M. M. Abou , Attia Amira S. A. , Abdel-Warith Abdel-Wahab A. , Darwish Manal M. , Younis Elsayed M. , Eltahlawi Rehab A. , Mohamed Kawthar Ibraheem , Davies Simon J. , Elsohaby Ibrahim 
Published: June 2024

IntroductionCandida albicans (C. albicans) can form biofilms; a critical virulence factor that provides effective protection from commercial antifungals and contributes to public health issues. The development of new antifungal therapies, particularly those targeting biofilms, is imperative. Thus, this study was conducted to investigate the antifungal and antibiofilm effects of Lactobacillus salivarius (L. salivarius), zinc nanoparticles (ZnNPs) and nanocomposites (ZnNCs) on C. albicans isolates from Nile tilapia, fish wash water and human fish sellers in Sharkia Governorate, Egypt.MethodsA cross-sectional study collected 300 samples from tilapia, fish wash water, and fish sellers (100 each). Probiotic L. salivarius was immobilized with ZnNPs to synthesize ZnNCs. The study assessed the antifungal and antibiofilm activities of ZnNPs, L. salivarius, and ZnNCs compared to amphotericin (AMB).ResultsCandida spp. were detected in 38 samples, which included C. albicans (42.1%), C. glabrata (26.3%), C. krusei (21.1%), and C. parapsilosis (10.5%). A total of 62.5% of the isolates were resistant to at least one antifungal agent, with the highest resistance to nystatin (62.5%). However, 75% of the isolates were highly susceptible to AMB. All C. albicans isolates exhibited biofilm-forming capabilities, with 4 (25%) isolates showing strong biofilm formation. At least one virulence-associated gene (RAS1, HWP1, ALS3, or SAP4) was identified among the C. albicans isolates. Probiotics L. salivarius, ZnNPs, and ZnNCs displayed antibiofilm and antifungal effects against C. albicans, with ZnNCs showing significantly higher inhibitory activity. ZnNCs, with a minimum inhibitory concentration (MIC) of 10 µg/mL, completely reduced C. albicans biofilm gene expression. Additionally, scanning electron microscopy images of C. albicans biofilms treated with ZnNCs revealed asymmetric, wrinkled surfaces, cell deformations, and reduced cell numbers.ConclusionThis study identified virulent, resistant C. albicans isolates with strong biofilm-forming abilities in tilapia, water, and humans, that pose significant risks to public health and food safety.
3D-printed resin composite posterior fixed dental prosthesis: a prospective clinical trial up to 1 year
Authors: Hobbi Paniz , Ordueri Tugce Merve , Öztürk-Bozkurt Funda , Toz-Akalın Tugba , Ateş Muzaffer , Özcan Mutlu 
Published: June 2024

ObjectivesThis clinical trial evaluated the clinical behavior of 3D-printed posterior resin composite fixed dental prostheses (FDPs).Materials and methodsBetween 10 October 2020 and 5 August 2022, 49 patients aged 19–60 years (16 men, 33 women) received 68 3D-printed resin composite 3-unit posterior FDPs (ELS Even Stronger, Saremco, Switzerland). FDPs were followed up 2 weeks after placement (baseline), 6 months after placement, and 1 year after placement by two independent calibrated observers using modified FDI criteria for anatomical form, secondary caries, marginal adaptation, surface roughness, color match, fracture of material, staining surface, staining margin, approximate anatomical form, retention, gingival health, and patient's view. Survival analyses were performed using Kaplan–Meier analyses.ResultsA total of 59 restorations were evaluated and the mean observation period was 8.63 months. Failure types were categorized as mechanical and biological. Failures were observed in 14 FDPs. Nine FDPs showed mechanical failure and five FDPs showed biological failure. Mechanical failures were mostly experienced as connector fractures. Eight FDPs showed cohesive fractures (seven in a single connector at either at the mesial or distal and one in the pontic itself). Biological failures, including root canal treatment and gingival tissue reactions, were observed within the first 6 months. Based on mechanical failures, the survival rate was 86.7% including the biological complications; this corresponded to 71.6% (Kaplan–Meier). After 1 year, two FDPs showed surface luster loss (score 4), two-color mismatches (score 4), and two-surface staining (score 4).Conclusion3D-printed resin composite FDPs were observed acceptable after 1 year of clinical follow-up, providing that the experienced failure types were mainly associated with fractures in the connector region, which requires revision of design parameters.Clinical Trial RegistrationClinical Trials.Gov, NCT04600297.
The effect of principal transformational leadership on teacher innovative behavior: the moderator role of uncertainty avoidance and the mediated role of the sense of meaning at work
Authors: Bao Yuangen 
Published: June 2024

IntroductionGiven the rapid technological advancements and increasing global uncertainties, principals’ promoting teacher innovative behavior (TIB) is fundamental for schools to enhance effectiveness and achieve sustainable competitive growth. However, previous research on the impact of principal transformational leadership (PTL) on TIB has yielded conflicting results. Drawing upon social cognitive theory and leadership substitution theory, this study constructs a model to elucidate the mediating role of teachers’ sense of meaning in work (TMW) between PTL and TIB, as well as the moderating role of teachers’ uncertain avoidance (TUA) in mainland China.MethodsThe model was examined in Chinese primary and secondary schools, with data gathered in January and July 2023. A total of 295 primary and secondary school teachers participated in this research. With Hayes’ PROCESS macro, we examined all the direct and indirect paths, including moderated mediation.ResultsThe findings confirm that PTL positively influences TIB, with TMW serving as a mediator in this relationship. Furthermore, TUA moderates both direct and indirect relationships mentioned above.DiscussionThese findings shed light on the underlying mechanisms through which principal transformational leadership impacts teacher innovative behavior. The implications derived from this conclusion offer valuable managerial insights for principals seeking to promote TIBs.
Identification of apoptosis-immune-related gene signature and construction of diagnostic model for sepsis based on single-cell sequencing and bulk transcriptome analysis
Authors: Sun Zhongyi , Hu Yanan , Qu Jiachen , Zhao Qiuyue , Gao Han , Peng Zhiyong 
Published: June 2024

IntroductionSepsis leads to multi-organ dysfunction due to disorders of the host response to infections, which makes diagnosis and prognosis challenging. Apoptosis, a classic programmed cell death, contributes to the pathogenesis of various diseases. However, there is much uncertainty about its mechanism in sepsis.MethodsThree sepsis gene expression profiles (GSE65682, GSE13904, and GSE26378) were downloaded from the Gene Expression Omnibus database. Apoptosis-related genes were obtained from the Kyoto Encyclopedia of Genes and Genomes Pathway database. We utilized LASSO regression and SVM-RFE algorithms to identify characteristic genes associated with sepsis. CIBERSORT and single cell sequencing analysis were employed to explore the potential relationship between hub genes and immune cell infiltration. The diagnostic capability of hub genes was validated across multiple external datasets. Subsequently, the animal sepsis model was established to assess the expression levels of hub genes in distinct target organs through RT-qPCR and Immunohistochemistry analysis.ResultsWe identified 11 apoptosis-related genes as characteristic diagnostic markers for sepsis: CASP8, VDAC2, CHMP1A, CHMP5, FASLG, IFNAR1, JAK1, JAK3, STAT4, IRF9, and BCL2. Subsequently, a prognostic model was constructed using LASSO regression with BCL2, FASLG, IRF9 and JAK3 identified as hub genes. Apoptosis-related genes were closely associated with the immune response during the sepsis process. Furthermore, in the validation datasets, aside from IRF9, other hub genes demonstrated similar expression patterns and diagnostic abilities as observed in GSE65682 dataset. In the mouse model, the expression differences of hub genes between sepsis and control group revealed the potential impacts on sepsis-induced organ injury.ConclusionThe current findings indicated the participant of apoptosis in sepsis, and apoptosis-related differentially expressed genes could be used for diagnosis biomarkers. BCL2, FASLG, IRF9 and JAK3 might be key regulatory genes affecting apoptosis in sepsis. Our findings provided a novel aspect for further exploration of the pathological mechanisms in sepsis.
Enhanced IL-12 transgene expression improves oncolytic viroimmunotherapy
Authors: Kim Yeaseul , Saini Uksha , Kim Doyeon , Hernandez-Aguirre Ilse , Hedberg Jack , Martin Alexia , Mo Xiaokui , Cripe Timothy P. , Markert James , Cassady Kevin A. , Dhital Ravi 
Published: June 2024

IntroductionMalignant peripheral nerve sheath tumors (MPNSTs) are aggressive sarcomas with unacceptably low cure rates occurring often in patients with neurofibromatosis 1 defects. To investigate oncolytic Herpes Simplex Virus (oHSV) as an immunotherapeutic approach, we compared viral replication, functional activity, and immune response between unarmed and interleukin 12 (IL-12)-armed oncolytic viruses in virus-permissive (B109) and -resistant (67C-4) murine MPNSTs.MethodsThis study compared two attenuated IL-12-oHSVs with γ134.5 gene deletions (Δγ134.5) and the same transgene expression cassette. The primary difference in the IL-12-oHSVs was in their ability to counter the translational arrest response in infected cells. Unlike M002 (Δγ134.5, mIL-12), C002 (Δγ134.5, mIL-12, IRS1) expresses an HCMV IRS1 gene and evades dsRNA activated translational arrest in infected cells.Results and discussionOur results show that oHSV replication and gene expression results in vitro were not predictive of oHSV direct oncolytic activity in vivo. Tumors that supported viral replication in cell culture studies resisted viral replication by both oHSVs and restricted M002 transgene expression in vivo. Furthermore, two IL-12-oHSVs with equivalent transcriptional activity differed in IL-12 protein production in vivo, and the differences in IL-12 protein levels were reflected in immune infiltrate activity changes as well as tumor growth suppression differences between the IL-12-oHSVs. C002-treated tumors exhibited sustained IL-12 production with improved dendritic cells, monocyte-macrophage activity (MHCII, CD80/CD86 upregulation) and a polyfunctional Th1-cell response in the tumor infiltrates.ConclusionThese results suggest that transgene protein production differences between oHSVs in vivo, in addition to replication differences, can impact OV-therapeutic activity.
SIRPG promotes lung squamous cell carcinoma pathogenesis via M1 macrophages: a multi-omics study integrating data and Mendelian randomization
Authors: Mao Guocai , Li Jing , Wang Nan , Yu Hongbin , Han Shiyu , Xiang Mengqi , Zhang Huachuan , Zeng Daxiong , Jiang Junhong , Ma Haitao 
Published: June 2024

BackgroundSquamous cell carcinoma of the lung (LUSC) is a severe and highly lethal malignant tumor of the respiratory system, and its molecular mechanisms at the molecular level remain unc\lear.MethodsWe acquired RNA-seq data from 8 surgical samples obtained from early-stage LUSC and adjacent non-cancerous tissues from 3 different centers. Utilizing Deseq2, we identified 1088 differentially expressed genes with |LogFC| &gt; 1 and a p-value &lt; 0.05 threshold. Furthermore, through MR analysis of Exposure Data for 26,153 Genes and 63,053 LUSC Patients, incorporating 7,838,805 SNPs as endpoints, we identified 213 genes as potential exposure factors.ResultsAfter intersecting the results, we identified 5 differentially expressed genes, including GYPE, PODXL2, RNF182, SIRPG, and WNT7A. PODXL2 (OR 95% CI, 1.169 (1.040 to 1.313)) was identified as an exposed risk factor, with p-values less than 0.01 under the inverse variance weighted model. GO and KEGG analyses revealed enhanced ubiquitin-protein transferase activity and activation of pathways such as the mTOR signaling pathway and Wnt signaling pathway. Immune infiltration analysis showed downregulation of Plasma cells, T cells regulatory (Tregs), and Dendritic cells activated by the identified gene set, while an enhancement was observed in Macrophages M1. Furthermore, we externally validated the expression levels of these five genes using RNA-seq data from TCGA database and 11 GEO datasets of LUSC, and the results showed SIRPG could induce LUSC.ConclusionSIRPG emerged as a noteworthy exposure risk factor for LUSC. Immune infiltration analysis highlighted Macrophages M1 and mTOR signaling pathway play an important role in LUSC.
Investment Decision Using Technical Analysis: A Study on Selected Stocks in Indian Stock Market
Authors: Logambal R , Kanagasabapathy G 
Published: June 2024

Technical analysis is a methodology in financial markets that asserts its capability to predict future stock directions by scrutinizing historical market data, patterns in price movements, and correlations between price and volume. Traders widely utilize these data in their decision- making processes. The approach also takes into account the real-time behavior of market prices and volumes, operating under the assumption that these are the most influential factors in determining a stock’s or market’s future trajectory. Investors often grapple with decisions regarding which stocks to buy, the optimal purchase quantities, and when to execute selling or holding actions to maximize profits in the trading period. This research delves into these considerations, offering insights for short-term traders by analyzing the stock price trends of twelve companies across three distinct sectors over the 2020-2022 period.
Role of Women in Economic Development in India
Authors: Jonitha Stany Mary B X 
Published: June 2024

Engaging women is a basic issue in non-industrial countries. Despite the fact that women are a vital piece of any general public, yet their association in dynamic by the utilization of their dynamic commitment in financial exercises is shallow. Women strengthening and monetary improvement are interlinked, where from one perspective, advancement alone can make light of a huge job in driving disparity among women and men while then again engaging women can help advancement. This paper investigates the job of women in the labor force for the monetary advancement of the country in various States.
A Study on Impact of Online Teaching among College Students in Madurai during Covid-19
Authors: Uma K. , Surendran K. , Deepthi Varsha Devi M. 
Published: June 2024

The newly identified virus, SARS-CoV-2, is responsible for the COVID-19 pandemic, resulting in numerous fatalities and widespread closures across various sectors. To keep the learning cycle going, schools are turning to online teaching platforms like Google Meet, Zoom, Microsoft Team, Cisco Webex, and Slack, among others. These are the platforms that protect students from the epidemic and promote their ability to learn continually through online learning. The study focuses on the shift of educational sectors from offline to online modes, with the goal of measuring students’ satisfaction levels with online classes.