bluuebunny/crossref_metadata_2025_split huggingface dataset:
Electrospun PEG–PLA nanofibrous membrane for sustained release of hydrophilic antibiotics
Authors: Xu Xiuling , Zhong Wen , Zhou Shufei , Trajtman Adriana , Alfa Michelle 
Published: May 2010

AbstractReported in this study is the successful incorporation of a hydrophilic antibiotic drug, tetracycline hydrochloride (TCH), into electrospun PEG–PLA nanofibrous membrane without loss of its bioactivity. Degradation behavior of the copolymer was studied in vitro. Release behavior of TCH from the electrospun membrane and antimicrobial effects of the TCH‐loaded membrane against Staphylococcus aureus culture were investigated. The medicated nanofibrous membrane demonstrated sustained release of TCH over 6 days and was found to be effective in inhibiting growth of S. aureus. In addition, increasing the antibiotic drug content in the electrospun membranes was found to enhance the anti‐bacterial effectiveness of the medicated fiber mats. And the combination of mechanical barriers provided by the electrospun biodegradable nanofibrous membranes and their capability of local sustained delivery of antibiotics made these membranes more useful in biomedical applications, particularly as new wound dressings for ulcers caused by diabetes or other diseases, and to provide a better means of treatment for these malignant wounds and ulcers. © 2010 Wiley Periodicals, Inc. J Appl Polym Sci, 2010
Thermal aging and oxygen permeation of nylon‐6 and nylon‐6/montmorillonite composites
Authors: Ito Mikiya , Nagai Kazukiyo 
Published: May 2010

AbstractNylon/clay nanocomposites are expected materials for the great improvement of various properties with small percent addition of clay; however, the degradation behavior and the long term stability of nanocomposites have been insufficiently studied. During the thermal aging in air atmosphere, Nylon is ordinarily affected by oxygen gas; therefore, the oxygen permeation under thermal aging condition is an important factor for considering the thermal degradation of Nylon. Moreover, to examine the relationship between the thermal degradation and the oxygen permeation, the oxygen permeation should be measured at the temperature higher than the temperature of respective Tg. According to the oxygen permeation measurement at the temperature of 65°C, the Nylon‐6/MMT nanocomposites indicate lower permeability coefficient than that of neat Nylon‐6 and Nylon‐6/MMT composites. On the other hand, the solubility coefficients of the MMT contained Nylon‐6 were similar to each other and the solubility coefficients were significantly higher than that of the neat Nylon‐6. This characteristic is presumable to be closely related with the thermal degradation of Nylon‐6. In case of the MMT contained Nylon‐6, the permeation of oxygen gas is slower than the case of neat Nylon‐6; however, it is conceivable that the oxygen gas permeates with some interactive influences on Nylon‐6 matrix. © 2010 Wiley Periodicals, Inc. J Appl Polym Sci, 2010
Effect of glycerol on solution properties governing morphology, glass transition temperature, and tensile properties of electrospun zein film
Authors: Wongsasulak Saowakon , Tongsin Paranat , Intasanta Narupol , Yoovidhya Tipaporn 
Published: May 2010

AbstractAn attempt was made to improve the tensile strength and elongation of electrospun zein film by addition of a plasticizer, namely, glycerol to the film forming solution. A surfactant viz. Tween®40 and NaCl were also added into the film solution to facilitate the electrospinning process. The effect of glycerol content on selected zein solution properties, i.e., surface tension, electrical conductivity, and viscosity, which in turn affect the mechanical property, morphology, and glass transition temperature (Tg) of the film were investigated. Morphology of the electrospun film was examined via scanning electron microscopy (SEM), whereas the film component was characterized by Fourier transform infrared (FTIR) spectroscopy. It was observed that as the glycerol content increased, the diameter of the electrospun fiber increased as a result of decreasing electrical conductivity with increasing surface tension of the solution. The flow‐behavior index of the solution indicated that glycerol had a significant impact on the solution flow property, hence improved fiber diameter uniformity. Besides, the tensile strength and elongation of the film were improved as glycerol content increased, but the reverse was noted at 10 wt %. Tg of the zein film decreased as the glycerol content increased. © 2010 Wiley Periodicals, Inc. J Appl Polym Sci, 2010
Transport selectivity of tribenuron‐methyl imprinted polymer nanowire membrane prepared using N,O‐bismethacryloyl ethanolamine as a functional crosslinking monomer
Authors: Liu Xufei , Zhou Jie , Chen Changbao 
Published: May 2010

AbstractUsing tribenuron‐methyl as a template and N,O‐bismethacryloyl ethanolamine as a functional crosslinking monomer, a molecularly imprinted nanowire membrane was prepared over an anodic alumina oxide membrane. The nanowire fabric of the imprinted membrane was established with a scanning electron microscope and a transmission electron microscope. However, the nonimprinted particulate membrane is formed in the absence of a template. Scatchard analysis showed that an equal class of binding sites were formed in the imprinted nanowire membrane and the dissociation constant and the maximum number of these binding sites were estimated to be 1.44 × 10−5 M and 22.7 µmol/g, respectively. The permeation experiments throughout the imprinted membrane and the nonimprinted one were carried out in a solution containing the template and its competitive analogs. These results demonstrated that the molecularly imprinted nanowire membrane exhibited higher transport selectivity for the template tribenuron‐methyl than its analogs, chlorimuron‐ethyl, thifensulfuron‐methyl and N‐(4‐bromophenylcarbamoyl)‐5‐chloro‐1H‐benzo[d]imidazole‐2‐carboxamide. But the nonimprinted granular membrane had no permselectivity for the four substrates. © 2010 Wiley Periodicals, Inc. J Appl Polym Sci, 2010
Hydroxylated Analogs of Mexiletine as Tools for Structural‐Requirements Investigation of the Sodium Channel Blocking Activity
Authors: Catalano Alessia , Carocci Alessia , Cavalluzzi Maria M. , Di Mola Antonia , Lentini Giovanni , Lovece Angelo , Dipalma Antonella , Costanza Teresa , Desaphy Jean‐François , Conte Camerino Diana , Franchini Carlo 
Published: May 2010

Abstract[2‐(2‐Aminopropoxy)‐1,3‐phenylene]dimethanol1and 4‐(2‐aminopropoxy)‐3‐(hydroxymethyl)‐5‐methylphenol2, two dihydroxylated analogs of mexiletine – a well known class IB anti‐arrhythmic drug – were synthesized and used as pharmacological tools to investigate the blocking‐activity requirements of human skeletal muscle, voltage‐gated sodium channel. The very low blocking activity shown by newly synthesized compounds corroborates the hypothesis that the presence of a phenolic group in the para‐position to the aromatic moiety and/or benzylic hydroxyl groups on the aromatic moiety of local anesthetic‐like drugs impairs either the transport to or the interaction with the binding site in the pore of Na+channels.
Blockade of the interleukin‐7 receptor inhibits collagen‐induced arthritis and is associated with reduction of T cell activity and proinflammatory mediators
Authors: Hartgring Sarita A. Y. , Willis Cynthia R. , Alcorn Dina , Nelson Laurel J. , Bijlsma Johannes W. J. , Lafeber Floris P. J. G. , van Roon Joel A. G. 
Published: May 2010

AbstractObjectiveTo study the effects of interleukin‐7 receptor α‐chain (IL‐7Rα) blockade on collagen‐induced arthritis (CIA) and to investigate the effects on T cell numbers, T cell activity, and levels of proinflammatory mediators.MethodsWe studied the effect of anti–IL‐7Rα antibody treatment on inflammation and joint destruction in CIA in mice. Numbers of thymocytes, splenocytes, T cell subsets, B cells, macrophages, and dendritic cells were assessed. Cytokines indicative of Th1, Th2, and Th17 activity and several proinflammatory mediators were assessed by multianalyte profiling in paw lysates. In addition, T cell–associated cytokines were measured in supernatants of lymph node cell cultures.ResultsAnti–IL‐7Rα treatment significantly reduced clinical arthritis severity in association with reduced radiographic joint damage. Both thymic and splenic cellularity were reduced after treatment with anti–IL‐7Rα. IL‐7Rα blockade specifically reduced the total number of cells as well as numbers of naive, memory, CD4+, and CD8+ T cells from the spleen and significantly reduced T cell–associated cytokines (interferon‐γ, IL‐5, and IL‐17). IL‐7Rα blockade also decreased local levels of proinflammatory cytokines and factors associated with tissue destruction, including tumor necrosis factor α, IL‐1β, IL‐6, matrix metalloproteinase 9, and RANKL. IL‐7Rα blockade did not significantly affect B cells, macrophages, and dendritic cells. B cell activity, indicated by serum anticollagen IgG antibodies, was not significantly altered.ConclusionBlockade of IL‐7Rα potently inhibited joint inflammation and destruction in association with specific reductions of T cell numbers, T cell–associated cytokines, and numerous mediators that induce inflammation and tissue destruction. This study demonstrates an important role of IL‐7R–driven immunity in experimental arthritis and indicates the therapeutic potential of IL‐7Rα blockade in human arthritic conditions.
Approximation and complexity trade‐off by TP model transformation in controller design: A case study of the TORA system
Authors: Petres Zoltán , Baranyi Péter , Hashimoto Hideki 
Published: May 2010

AbstractThe main objective of the paper is to study the approximation and complexity trade‐off capabilities of the recently proposed tensor product distributed compensation (TPDC) based control design framework. The TPDC is the combination of the TP model transformation and the parallel distributed compensation (PDC) framework. The Tensor Product (TP) model transformation includes an Higher Order Singular Value Decomposition (HOSVD)‐based technique to solve the approximation and complexity trade‐off. In this paper we generate TP models with different complexity and approximation properties, and then we derive controllers for them. We analyze how the trade‐off effects the model behavior and control performance. All these properties are studied via the state feedback controller design of the Translational Oscillations with an Eccentric Rotational Proof Mass Actuator (TORA) System.Copyright © 2010 John Wiley and Sons Asia Pte Ltd and Chinese Automatic Control Society
Impact and clinical significance of recurrent venous thromboembolism
Authors: Labropoulos N , Spentzouris G , Gasparis A P , Meissner M 
Published: May 2010

AbstractBackgroundThe purpose of this review was to analyse current knowledge and controversies associated with the diagnosis, treatment and prevention of recurrent venous thromboembolism (VTE).MethodsMEDLINE and manual searches were performed to select prospective papers on the diagnosis, treatment and prevention of recurrent VTE for their relevance and quality.ResultsThe cumulative incidence of recurrent VTE increases from 11 per cent at 1 year to 40 per cent at 10 years. The incidence of recurrence is higher in unprovoked thrombosis compared with provoked VTE. Patients with unprovoked deep vein thrombosis also have a greater number of multiple recurrences. Ultrasonography or D-dimer monitoring may have an impact on the duration of anticoagulation but further refinements are needed. The incidence of skin damage is higher in ipsilateral recurrence compared with contralateral or no recurrence. Legs with ipsilateral recurrence more often have both reflux and obstruction.ConclusionThe role and weight of the predictive factors for recurrent VTE and its sequelae, and the type and optimal duration of anticoagulation have not been studied adequately. Fatality associated with pulmonary embolism and rates of recurrent VTE remain unacceptably high.
Biosynthesis of the Myxobacterial Antibiotic Corallopyronin A
Authors: Erol Özlem , Schäberle Till F. , Schmitz Alexander , Rachid Shwan , Gurgui Cristian , El Omari Mustafa , Lohr Friederike , Kehraus Stefan , Piel Jörn , Müller Rolf , König Gabriele M. 
Published: May 2010

AbstractCorallopyronin A is a myxobacterial compound with potent antibacterial activity. Feeding experiments with labelled precursors resulted in the deduction of all biosynthetic building blocks for corallopyronin A and revealed an unusual feature of this metabolite: its biosynthesis from two chains, one solely PKS‐derived and the other NRPS/PKS‐derived. The starter molecule is believed to be carbonic acid or its monomethyl ester. The putative corallopyronin A biosynthetic gene cluster is a trans‐AT‐type mixed PKS/NRPS gene cluster, containing a β‐branching cassette. Striking features of this gene cluster are a NRPS‐like adenylation domain that is part of a PKS‐type module and is believed to be responsible for glycine incorporation, as well as split modules with individual domains occurring on different genes. It is suggested that CorB is a trans‐acting ketosynthase and it is proposed that it catalyses the Claisen condensation responsible for the interconnection of the two chains. Additionally, the stereochemistry of corallopyronin A was deduced by a combination of a modified Mosher's method and ozonolysis with subsequent chiral GC analyses.
Creating Chemical Diversity in Indole Compounds by Merging Au and Ru Catalysis
Authors: Bandini Marco , Eichholzer Astrid , Gualandi Andrea , Quinto Tommaso , Savoia Diego 
Published: May 2010

AbstractSequential dual‐metal catalyzed reactions are successfully applied to create chemical diversity in indole polycyclic alkaloids. Gold‐catalyzed intramolecular allylic alkylation of indoles with alcohols, followed by Ru‐assisted ring‐closing metathesis opens up access to a large variety of functionalized tetrahydrocarbazoles and tetrahydro‐β‐carbolines in a straightforward manner. The gold‐catalyzed alkylation allows complex molecular architectures to be realized in a highly regio‐ and stereocontrolled manner.
Evaluation of the evidential value of physicochemical data by a Bayesian network approach
Authors: Zadora Grzegorz 
Published: May 2010

AbstractThe growing interest in applications of Bayesian networks (BNs) in forensic science raises the question of whether BN could be used in forensic practice for the evaluation of results from physicochemical analysis of a limited number of observations from flammable liquids (weathered kerosene and diesel fuel) by automated thermal desorption gas chromatography mass spectrometry (ATD‐GC/MS), car paints by pyrolysis gas chromatography mass spectrometry (Py‐GC/MS) and fibres by microspectrophotometry (MSP) in the visible (VIS) range. Therefore, various simple BN models, which allow the evaluation of both discrete and continuous types of data, were studied in order to address questions raised by the representatives of the administration of justice, concerning the identification and classification of objects into certain categories and/or the association between two items. The results of the evaluation performed by BN models were expressed in the form of a likelihood ratio, which is a well‐documented measure of evidential value in the forensic field. From the results obtained, it can be concluded that BN models seem to be promising tool for evaluating physicochemical data. Copyright © 2010 John Wiley & Sons, Ltd.
Inter‐ and Intramolecular Photoinduced Electron Transfer of Flavin Derivatives with Extremely Small Reorganization Energies
Authors: Murakami Motonobu , Ohkubo Kei , Fukuzumi Shunichi 
Published: May 2010

AbstractPhotoinduced electron transfer (ET) of a series of aromatic electron donors (D) to the singlet or triplet excited state of a flavin analogue (10‐methylisoalloxazine: MeFl) and intermolecular back electron transfer (BET) from MeFl.− to D.+ in benzonitrile (PhCN) has been investigated in light of the Marcus theory of ET. The rate constants of intermolecular photoinduced ET (ket) from D to the singlet excited state (1MeFl*) and the triplet excited state (3MeFl*) were determined by fluorescence quenching and enhanced decay rates of triplet–triplet (T–T) absorption by the presence of D, respectively. The ket values increase with an increase in the ET driving force to reach the diffusion‐limit value that remains constant with a further increase in the ET driving force. Nanosecond laser flash photolysis was performed to determine the rate constants of intermolecular BET (kbet) from MeFl.− to D.+ in PhCN. In contrast to the case of ket, the driving force dependence of kbet shows a pronounced decrease towards the highly exothermic region. The reorganization energy (λ) of intermolecular BET is determined to be 0.68 eV by applying the Marcus equation in the inverted region, where the kbet value decreases with increasing the BET driving force. The slowest BET was observed for BET from MeFl.− to N,N‐dimethylaniline radical cation (DMA.+) with the kbet value of 3.5×106 M−1 s−1, which is 1600 times smaller than the diffusion rate constant in PhCN (5.6×109 M−1 s−1). Then, DMA was linked to the 10‐position of isoalloxazine to synthesize a DMA–flavin linked dyad (10‐[4′‐(N,N‐dimethylamino)phenyl]–isoalloxazine: DMA–Fl). Photoexcitation of DMA–Fl results in photoinduced ET from the DMA moiety to the singlet excited state of Fl moiety to form the charge‐separated (CS) state (DMA.+–Fl.−) that has an extremely long lifetime (2.1 ms) in PhCN at 298 K.
Luminescent Amphiphilic 2,6‐Bis(1‐alkylpyrazol‐3‐yl)pyridyl Platinum(II) Complexes: Synthesis, Characterization, Electrochemical, Photophysical, and Langmuir–Blodgett Film Formation Studies
Authors: Zhao Le , Wong Keith Man‐Chung , Li Bao , Li Wen , Zhu Nianyong , Wu Lixin , Yam Vivian Wing‐Wah 
Published: May 2010

AbstractTwo series of novel platinum(II) 2,6‐bis(1‐alkylpyrazol‐3‐yl)pyridyl (N5Cn) complexes, [Pt(N5Cn)Cl][X] (1–9) and [Pt(N5Cn)(CCR)][X] (10–13) (X=trifluoromethanesulfonate (OTf) or PF6; R=C6H5, C6H4‐p‐CF3 and C6H4‐p‐N(C6H5)2), with various chain lengths of the alkyl groups on the nitrogen atom of the pyrazolyl units have been successfully synthesized and characterized. Their electrochemical and photophysical properties have been studied. Some of their molecular structures have also been determined by X‐ray crystallography. Two amphiphilic platinum(II) 2,6‐bis(1‐tetradecylpyrazol‐3‐yl)pyridyl (N5C14) complexes, [Pt(N5C14)Cl]PF6 (7) and [Pt(N5C14)(CCC6H5)]PF6 (13), were found to form stable and reproducible Langmuir–Blodgett (LB) films at the air–water interface. The characterization of such LB films has been investigated by the study of their surface pressure–area (π–A) isotherms, UV/Vis spectroscopy, XRD, X‐ray photoelectron spectroscopy (XPS), FTIR, and polarized IR spectroscopy. The luminescence property of 13 in LB films has also been studied.
ChemInform Abstract: Novel Buspirone‐Like 5‐HT1A Receptor Ligands
Authors: Krajewski K. J. , Les A. , Cybulski J. , Chilmonczyk Z. , Bronowska A. , Szelejewska‐Wozniakowska A. 
Published: May 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Enhanced Visible Light Conversion Efficiency Using Nanocrystalline WO3 Films.
Authors: Santato Clara , Ulmann Martine , Augustynski Jan 
Published: May 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis of 3‐(3,4‐Dimethoxyphenyl)‐1H‐1,2,4‐triazole‐5‐thiol and 2‐Amino‐5‐(3,4‐dimethoxyphenyl)‐1,3,4‐thiadiazole Derivatives Exhibiting Antiinflammatory Activity.
Authors: Labanauskas L. , Kalcas V. , Udrenaite E. , Gaidelis P. , Brukstus A. , Dauksas V. 
Published: May 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Semiconductor‐Based Composite Materials: Preparation, Properties, and Performance
Authors: Rajeshwar Krishnan , de Tacconi Norma R. , Chenthamarakshan C. R. 
Published: May 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Luminescence Properties of Nanocrystalline Y2O3:Eu.
Authors: Wakefield Gareth , Holland Edward , Dobson Peter J. , Hutchinson John L. 
Published: May 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: (+)‐Camphor‐Derived Amino Alcohols as Ligands for the Catalytic Enantioselective Additions of Diethylzinc to Benzaldehydes.
Authors: Nevalainen Marta , Nevalainen Vesa 
Published: May 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: New Synthetic Method of Benzaldehydes and α,β‐Unsaturated Aldehydes with I2 under Photoirradiation.
Authors: Itoh Akichika , Kodama Tomohiro , Masaki Yukio 
Published: May 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Selective Upper‐Rim Adamantylation of Calix[4]arenes.
Authors: Shokova E. A. , Khomich A. N. , Kovalev V. V. 
Published: May 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: A Facile Synthesis of Aminoiminomethanesulfonic Acid.
Authors: Pan Fenggang , Pan Zhixin 
Published: May 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Stereoselective Synthesis of (Z)‐Enethiols and Their Derivatives: Vinylic SN2 Reaction of (E)‐Alkenyl(phenyl)‐λ3‐iodanes with Thioamides.
Authors: Ochiai' Masahito , Yamamoto Shinji , Suefuji Takashi , Chen Da‐Wei 
Published: May 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.