bluuebunny/crossref_metadata_2025_split huggingface dataset:
404‐error “Disease not found”: Unleashing the translational potential of ‐omics approaches beyond traditional disease classification in heart failure research
Authors: Esquivel Gaytan Antonio , Bomer Nils , Grote Beverborg Niels , van der Meer Peter 
Published: May 2024

AbstractThe emergence of personalized medicine, facilitated by the progress in ‐omics technologies, has initiated a new era in medical diagnostics and treatment. This review examines the potential of ‐omics approaches in heart failure, a condition that has not yet fully capitalized on personalized strategies compared to other medical fields like cancer therapy. Here, we argue that integrating multi‐omics technology with systems medicine approaches could fundamentally transform heart failure management, moving away from the traditional paradigm of ‘one size fits all’. Our review examines how omics can enhance understanding of heart failure's molecular foundations and contribute to a more comprehensive disease classification. We draw attention to the current state of medical practice that only relies on clinical evidence and a number of standard laboratory tests. At the same time, we propose a shift towards a universal approach that uses quantitative data from multi‐omics to unravel complex molecular interactions. The discussion centres around the potential of the transition as a means to enhance individual risk assessment and emphasizes management within clinical settings. While the use of omics in cardiovascular research is not recent, many past studies have focused only on a single omics approach. In order to achieve a better understanding of disease mechanisms, we explore more holistic approaches using genomics, transcriptomics, epigenomics, and proteomics. This review concludes with a call to action to adopt multi‐omics in clinical trials and practice to pave the way for more personalized disease management and more effective heart failure interventions.
Measuring congestion with a non‐invasive monitoring device in heart failure and haemodialysis: CONGEST‐HF
Authors: Curtain James P. , Talebi Atefeh , McIntosh Alasdair , McConnachie Alex , O'Donnell Joanne , Welsh Paul , Osmanska Joanna , Lee Matthew M.Y. , Sonecki Piotr , Akl Tony , Seo Joohyun , Gopinathan Venugopal , Hurwitz Jed , Thiagarajan Srikanth , Pettit Stephen , Kalra Paul R. , Patel Rajan K. , Mark Patrick B. , Lang Ninian N. , McMurray John J.V. , Petrie Mark C. , Gardner Roy S. , Jhund Pardeep S. 
Published: May 2024

AimsWe examined the effectiveness of a novel cardiopulmonary management wearable sensor (worn for less than 5 mins) at measuring congestion and correlated the device findings with established clinical measures of congestion.Methods and resultsWe enrolled three cohorts of patients: (1) patients with heart failure (HF) receiving intravenous diuretics in hospital; (2) patients established on haemodialysis, and (3) HF patients undergoing right heart catheterization (RHC). The primary outcomes in the respective cohorts were a Spearman correlation between (1) change in weight and change in thoracic impedance (TI) (from enrolment, 24 h after admission to discharge) in patients hospitalized for HF; (2) lung ultrasound B‐lines and volume removed during dialysis with device measured TI, and (3) pulmonary capillary wedge pressure (PCWP) and sub‐acoustic diastolic, third heart sound (S3) in the patients undergoing RHC. A total of 66 patients were enrolled. In HF patients (n = 25), change in weight was correlated with both change in device TI (Spearman correlation [rsp] = −0.64, p = 0.002) and change in device S3 (rsp = −0.53, p = 0.014). In the haemodialysis cohort (n = 21), B‐lines and TI were strongly correlated before (rsp = −0.71, p < 0.001) and after (rsp = −0.77, p < 0.001) dialysis. Volume of fluid removed by dialysis was correlated with change in device TI (rsp = 0.49, p = 0.024). In the RHC cohort (n = 20), PCWP measured at one time point and device S3 were not significantly correlated (rsp = 0.230, p = 0.204). There were no device‐related adverse events.ConclusionsA non‐invasive device was able to detect changes in congestion in patients with HF receiving decongestion therapy and patients having fluid removed at haemodialysis. The cardiopulmonary management device, which measures multiple parameters, is a potentially useful tool to monitor patients with HF to prevent hospitalizations.
High‐yield upcycling of feather wastes into solid‐state ultra‐long phosphorescence carbon dots for advanced anticounterfeiting and information encryption
Authors: Chen Dongzhi , Guo Xin , Sun Xuening , Feng Xiang , Chen Kailong , Zhang Jinfeng , Zhu Zece , Zhang Xiaofang , Liu Xin , Liu Min , Li Li , Xu Weilin 
Published: May 2024

AbstractRecently, biomass‐derived carbon dots (CDs) have attracted considerable attention in high‐technology fields due to their prominent merits, including brilliant luminescence, superior biocompatibility, and low toxicity. However, most of the biomass‐derived CDs only show bright fluorescence in diluted solution because of aggregation‐induced quenching effect, hence cannot exhibit solid‐state long‐lived room‐temperature phosphorescence (RTP) in ambient conditions. Herein, matrix‐free solid‐state RTP with an average lifetime of 0.50 s is realized in the CDs synthesized by one‐pot hydrothermal treatment of duck feather waste powder. To further enhance RTP lifetime, hydrogen bonding is introduced by employing polyols like polyvinyl alcohol (PVA) and phytic acid (PA), and a bimodal luminescent CDs/PVA/PA ink is exploited by mixing the CDs and polyols. Astonishingly, the CDs/PVA/PA ink screen‐printed onto cellulosic substrates exhibits unprecedented green RTP with average lifetime of up to 1.97 s, and the afterglow lasts for more than 14 s after removing UV lamp. Such improvement on RTP is proposed to the populated excited triplet excitons stabilized by rigid chains. Furthermore, the CDs/PVA/PA ink demonstrates excellent potential in anticounterfeiting and information encryption. To the best of the authors' knowledge, this work is the first successful attempt to fabricate matrix‐free ultra‐long RTP CDs by reclamation of the feather wastes for environmental sustainability.
Forecasting stock returns with industry volatility concentration
Authors: Zhang Yaojie , He Mengxi , Zhang Zhikai 
Published: May 2024

AbstractIn this paper, we show that industry volatility concentration is a strong predictor for aggregate stock market returns. Our monthly industry volatility concentration (IVC) index displays significant predictive ability, with in‐sample and out‐of‐sample R2 statistics of 0.686% and 0.712%, respectively, which outperforms a host of prevailing return predictors. Moreover, the IVC index can generate high utility gains of 143.8 basis points above the historical average benchmark for mean–variance investors. We find that the IVC index is countercyclical. Furthermore, the predictive source of the IVC index not only stems from the cash flow and discount rate channels but is also explained by the channels of investor attention and sentiment. The predictive ability of our IVC index also remains significant under a broad range of robustness tests.
Metabolomic insights into Monascus‐fermented rice products: Implications for monacolin K content and nutritional optimization
Authors: Zhao Yongxia , Luo Mingxia , Jiang Qin , Ma Yuhan , Liu Xiaoqi , Bai Xue , Zhou Lihong , Xie Jian 
Published: May 2024

AbstractThis study aims to elucidate the detailed metabolic implications of varying monacolin K levels and sterilization methods on Monascus‐fermented rice products (MFRPs), acclaimed for their health benefits and monacolin K content. Advanced metabolite profiling of various MFRP variants was conducted using ultrahigh‐performance liquid chromatography coupled with tandem time‐of‐flight mass spectrometry (UHPLC‐Q‐TOF MS). Statistical analysis encompassed t‐tests, ANOVA, and multivariate techniques including PCA, PLS‐DA, and OPLS‐DA. Notable variations in metabolites were observed across MFRPs with differing monacolin K levels, particularly in variants such as MR1‐S, MR1.5‐S, MR2‐S, and MR3‐S. Among the 524 identified metabolites, significant shifts were noted in organic acids, derivatives, lipids, nucleosides, and organic oxygen compounds. The study also uncovered distinct metabolic changes resulting from different sterilization methods and the use of highland barley as a fermentation substitute for rice. Pathway analysis shed light on affected metabolic pathways, including those involved in longevity regulation, cGMP‐PKG signaling, and the biosynthesis of unsaturated fatty acids. The research provides critical insights into the complex metabolic networks of MFRPs, underscoring the impact of fermentation substrates and conditions on monacolin K levels and their health implications. This study not only guides the nutritional optimization of MFRPs but also emphasizes the strategic importance of substrate choice and sterilization techniques in enhancing the nutritional and medicinal value of these functional foods.
Restriction on molecular fluxionality by substitution: A case study for the 1,10‐dicyanobullvalene
Authors: Pei Bin‐Bin , Yang Hongjuan , Gao Cai‐Yue , Man Yuan , Yang Yonggang , Li Si‐Dian 
Published: May 2024

AbstractWe show herein that 1,10‐dicyano substitution restricts the paragon fluxionality of bullvalene to just 14 isomers which isomerize along a single cycle. The restricted fluxionality of 1,10‐dicyanobullvalene (DCB) is investigated by means of: (i) Bonding analyses of the isomer structures using the adaptive natural density partitioning (AdNDP). (ii) Quantum dynamical simulations of the isomerizations along the cyclic intrinsic reaction coordinate of the potential energy surface (PES). The PES possesses 14 equivalent potential wells supporting 14 isomers which are separated by 14 equivalent potential barriers supporting 14 transition states. Accordingly, at low temperatures, DCB appears as a hindered molecular rotor, without any delocalization of the wavefunction in the 14 potential wells, without any nuclear spin isomers, and with completely negligible tunneling. These results are compared and found to differ from those for molecular boron rotors. (iii) Born‐Oppenheimer molecular dynamics (BOMD) simulations of thermally activated isomerizations. (iv) Calculations of the rate constants in the frame of transition state theory (TST) with reasonable agreement achieved with the BOMD results. (v) Simulations of the equilibration dynamics using rate equations for the isomerizations with TST rate coefficients. Accordingly, in the long‐time limit, isomerizations of the 14 isomers, each with Cs symmetry, approach the “14 Cs → C7v” thermally averaged structure. This is a superposition of the 14 equally populated isomer structures with an overall C7v symmetry. By extrapolation, the results for DCB yield working hypotheses for so far un‐explored properties e.g. for the equilibration dynamics of C10H10.
t2gd orbital ordering patterns in KBF3 (B = Sc, Ti, Fe, Co) perovskites
Authors: Pascale Fabien , D'Arco Philippe , Mustapha Sami , Dovesi Roberto 
Published: May 2024

AbstractThe orbital ordering (OO) resulting from the partial occupancy of the subshell of the transition metals in KBF (B = Sc, Ti, Ffe, Co) perovskites, and the many possible patterns arising from the coupling between the B sites, have been investigated at the quantum mechanical level ( Gaussian type basis set, B3LYP hybrid functional) in a 40 atoms supercell. The numerous patterns are distributed into 162 classes of equivalent configurations. For each fluoroperovskite, one representative per class has been calculated. The four compounds behave similarly: an identical dependence of the energy and volume (or cell parameters) on the OO pattern; the spanned energy interval is small (1 to 2 mE per formula unit), suggesting that most of the configurations are occupied at room and even at low temperature. A linear model, taking into account the relative orbital order in contiguous sites, reproduces the energy order in the full set for each compound, suggesting that it could be used for studying OO in larger supercells.
How people react to suicidal ideation: The effect of suicide literacy, suicide stigma, and expressive suppression
Authors: An Soontae , Lee Hannah , Lee Jiyoon 
Published: May 2024

AbstractIntroductionThe purpose of this study is to understand the role of suicide literacy and suicide stigma in laypeople's intention to recommend professional help in Korea. Additionally, the study focuses on the role of expressive suppression as a sociocultural factor.MethodsParticipants read vignettes depicting either subclinical distress or suicidal ideation and answered questions measuring suicide literacy, stigma, and expressive suppression. Mediated moderation analyses were used to examine the interactions between these factors.ResultsThe result found the significant effect of expressive suppression. The mediating effect of suicide stigma on the relationship between suicide literacy and recommendation of professional help was significant for those who do not suppress their emotions. This result indicates that when individuals were not hesitant to express negative emotions, high suicide literacy lowered suicide stigma and led to more willingness to recommend professional help.ConclusionsThe results showed that expressive suppression acts as a barrier deterring Koreans from professional help for their mental health. The findings underscore the importance of sociocultural factors such as expressive suppression in developing suicide prevention strategies.
FTO blocks RNA translational activity via the loss of N6‐methyladenosine methylation at 5′ UTR regulated by RBM5 in cisplatin‐resistant NSCLC
Authors: Li Liantao , Qu Debao , Wang Bo , Yuan Shiwang , Zhao Yang , Liu Nianli , Huo Fuchun , Zhang Dan , Zhang Longzhen 
Published: May 2024

AbstractN6‐methyladenosine (m6A) methylation has been widely regarded in numerous biological functions including CR. Nonetheless, the molecular process of m6A methylation behind CR in non‐small cell lung cancer (NSCLC) has no apparent significance. We identified in this study that the expression of FTO alpha‐ketoglutarate dependent dioxygenase (FTO) was downregulated in CR NSCLC tissues and cells in vivo and in vitro. Additionally, RIP‐seq indicated that loss of FTO contributed to the elevated m6A methylation at 5′‐untranslated region of RNAs which were closely connected with tumor resistance and malignancy, and FTO exerted to exclude the recruitment of eIF3A to these target genes in CR NSCLC. Moreover, FTO‐enriched transcripts displayed a reduced translational capability in CR NSCLC compared to the regular NSCLC cells. Finally, we also identified RNA binding motif protein 5 (RBM5) that could specially interact with FTO in regular NSCLC compared to CR NSCLC. Deficiency of RBM5 resulted in the abnormal recognition of transcripts by FTO, and led to the translation silencing of genes associated with CR such as ATP7A, ERCC1, CD99, CDKN3, XRCC5, and NOL3. Taken together, our data characterized FTO as a novel translation regulator and revealed the molecular mechanism on gene translation through the synergistic effects with RBM5 and m6A methylation in CR NSCLC cells.
Exploring the role of digital tools in rare disease management: An interview‐based study
Authors: Chang Andrea , Huang Sarah D. , Benjamin Daniel J. , Schmidt Johanna L. , Palmer Christina G. S. , Garrison Nanibaa’ A. 
Published: May 2024

AbstractWhile digital tools, such as the Internet, smartphones, and social media, are an important part of modern society, little is known about the specific role they play in the healthcare management of individuals and caregivers affected by rare disease. Collectively, rare diseases directly affect up to 10% of the global population, suggesting that a significant number of individuals might benefit from the use of digital tools. The purpose of this qualitative interview‐based study was to explore: (a) the ways in which digital tools help the rare disease community; (b) the healthcare gaps not addressed by current digital tools; and (c) recommended digital tool features. Individuals and caregivers affected by rare disease who were comfortable using a smartphone and at least 18 years old were eligible to participate. We recruited from rare disease organizations using purposive sampling in order to achieve a diverse and information rich sample. Interviews took place over Zoom and reflexive thematic analysis was utilized to conceptualize themes. Eight semistructured interviews took place with four individuals and four caregivers. Three themes were conceptualized which elucidated key aspects of how digital tools were utilized in disease management: (1) digital tools should lessen the burden of managing a rare disease condition; (2) digital tools should foster community building and promote trust; and (3) digital tools should provide trusted and personalized information to understand the condition and what the future may hold. These results suggest that digital tools play a central role in the lives of individuals with rare disease and their caregivers. Digital tools that centralize trustworthy information, and that bring the relevant community together to interact and promote trust are needed. Genetic counselors can consider these ideal attributes of digital tools when providing resources to individuals and caretakers of rare disease.
What do patients and families observe about pediatric safety?: A thematic analysis of real‐time narratives
Authors: Studenmund Christine , Lyndon Audrey , Stotts James R. , Peralta‐Neel Caroline , Sharma Anjana E. , Bardach Naomi S. 
Published: May 2024

AbstractObjectivesData on inpatient safety are documented by hospital staff through incident reporting (IR) systems. Safety observations from families or patients are rarely captured. The Family Input for Quality and Safety (FIQS) study created a mobile health tool for pediatric patients and their families to anonymously report safety observations in real time during hospitalization. The study objectives were to describe these observations and identify domains salient to safety.MethodsIn this observational study, we analyzed pediatric patient safety reports from June 2017 to April 2018. Participants were: English‐speaking family members and hospitalized patients ≥13 years old. The analysis had two stages: (1) assessment of whether narratives met established safety event criteria and whether there were companion IRs; (2) thematic analysis to identify domains.ResultsOf 248 enrolled participants, 58 submitted 120 narrative reports. Of the narratives, 68 (57%) met safety event criteria, while only 1 (0.8%) corresponded to a staff‐reported IR. Twenty‐five percent of narratives shared positive feedback about patient safety efforts; 75% shared constructive feedback. We identified domains particularly salient to safety: (1) patients and families as safety actors; (2) emotional safety; (3) system‐centered care; and (4) shared safety domains, including medication, communication, and environment of care. Some domains capture data that is otherwise difficult to obtain (#1–3), while others fit within standard healthcare safety domains (#4).ConclusionsPatients and families observe and report salient safety events that can fill gaps in IR data. Healthcare leaders should consider incorporating patient and family observations—collected with an option for anonymity and eliciting both positive and constructive comments.
Revitalizing brain perfusion: Unveiling advancements through rhythm control strategies in atrial fibrillation—A systematic review
Authors: Rasti Shinta Dewi , Sugiarto Adra Achirultan Ramainaldo , Nuryandi Audia Putri Amalia , Arvianti Militanisa Zamzara , Yomara Romadhana Trisnha , Nagasastra Jeffri , Julario Rerdin , Fagi Rosi Amrilla , Windrati Diah Mustika Hesti 
Published: May 2024

AbstractBackgroundRecent evidence suggests an elevated risk of cognitive impairment and dementia in individuals with atrial fibrillation (AF), irrespective of stroke occurrence. AF, known to reduce brain perfusion, particularly through silent cerebral ischemia, underscores the intricate relationship between cardiac and cerebral health. The heart plays a crucial role in supporting normal brain function, and rhythm control, a standard AF treatment, has demonstrated enhancements in brain perfusion. This systematic review aimed to examine published data concerning the influence of rhythm control on brain perfusion in patients with atrial fibrillation.MethodsA systematic search for relevant studies was carried out in Scopus, PubMed, Cochrane Reviews, ProQuest, and EBSCOhost, spanning from their inception until April 30, 2023. Studies that specifically examined brain perfusion following any form of rhythm control in atrial fibrillation were included in the review.ResultsThe review encompassed 10 studies involving 436 participants. Among these, six utilized electrical cardioversion for rhythm control. The majority (8 out of 10) demonstrated that restoring sinus rhythm markedly enhances brain perfusion. In one of the two remaining studies, notable improvement was observed specifically in a region closely linked to cognition. Additionally, both studies reporting data on the Mini‐Mental State Examination (MMSE) showed a consistent and significant increase in scores following rhythm control.ConclusionSuccessful rhythm control in AF emerges as a significant contributor to enhanced brain perfusion, suggesting a potential therapeutic avenue for reducing cognitive impairment incidence. However, further validation through larger prospective studies and randomized trials is warranted.
Prospective Outcomes of Microlaryngoscopy Versus Office Laser Photoangiolysis for Vocal Fold Polyps
Authors: Chadwick Keith A. , Andreadis Katerina , Sulica Lucian 
Published: May 2024

Objective(s)The objective of this study is to compare treatment outcomes for vocal fold polyps (VFPs) between operating room microlaryngoscopy and office‐based photoangiolysis with the potassium titanyl phosphate (KTP) laser.MethodsProspective nonrandomized cohort study of patients with VFPs undergoing microlaryngoscopy (“OR group”) or KTP laser photoangiolysis (“KTP group”). Voice outcomes (patient‐reported outcome measures [Voice Handicap Index‐10 (VHI‐10) and Singing VHI‐10 (SVHI‐10)], auditory‐perceptual measures [Consensus Auditory‐Perceptual Evaluation of Voice (CAPE‐V)], videostroboscopic characteristics [Voice‐Vibratory Assessment of Laryngeal Imaging (VALI)], and acoustic and aerodynamic measures) were performed at baseline and regular intervals after intervention.ResultsForty‐four subjects (17 OR group, 27 KTP group) with VFPs were enrolled. Mean VHI‐10 significantly improved from baseline to each follow‐up interval in both groups, except for the 1–2‐week interval in the OR group. Mean SVHI‐10 improved for both groups at some intervals. Growth curve models and time‐to‐event analyses for patient‐reported outcomes did not differ between groups. There were significant improvements in all categories of auditory‐perceptual voice quality and some categories of videostroboscopic characteristics in both groups. No significant trends were identified in acoustic and aerodynamic measures. Improvements in most outcomes did not significantly differ between groups or based on polyp size. There were no major complications.ConclusionsSignificant improvements in patient‐reported voice outcomes measures, auditory‐perceptual voice evaluation, and videostroboscopic characteristics occur following surgical treatment of vocal fold polyps with either microlaryngoscopy or office‐based KTP laser. Long‐term voice outcomes do not significantly differ between treatment modalities.Level of Evidence3 Laryngoscope, 134:S1–S20, 2024