bluuebunny/crossref_metadata_2025_split huggingface dataset:
Knowledge and attitude on umbilical cord blood stem cell therapy among bachelor nursing students in Lalitpur Metropolitan City
Authors: Bajracharya Karuna 
Published: June 2024

Background: Stem cells are immature cells that have ability to mature into different types of functioning cells as needed by body. Umbilical cord blood is one of the richest sources of stem cells. It is vital for nurses to keep up-to-date of current advances in stem cell science and nurses can play crucial role in providing first-hand information to public about stem cell and umbilical cord blood banking. Therefore, this study is aimed to identify the knowledge and attitude regarding umbilical cord blood stem cell therapy among bachelor nursing students.
Method: A descriptive cross sectional research design was used to assess the knowledge and attitude of 263 nurses studying bachelor in nursing science and post basic bachelor in nursing in different selected nursing college of Lalitpur metropolitan city. Multi stage cluster sampling was used to select respondents. Data was collected using self-developed self-administered google form questionnaire.
Results: Most of the nurses had poor knowledge (49.4%) and few nurses had good knowledge (6.8%) however majority of nurses (93.9%) had favourable attitude regarding umbilical cord blood stem cell therapy. Regarding association between variable, there is no any association between knowledge level and attitude (p=0.224).
Conclusion: Nurses had poor knowledge and favourable attitude regarding umbilical cord blood stem cell therapy.

Keywords: Nurses,Stem cells, Umbilical cord blood
Peran Zakat dan Wakaf Dalam Meningkatkan Kesejahteraan Ekonomi Masyarakat
Authors: Miranda Febrianti  , Rettinda Dwi Ulantari  , Selvi Desfriyanti  , Muhammad Dicky Candra  , Gustin Rianita  , Dwie Juniar Puteri  
Published: June 2024

This research aims to explore and analyze the roles of zakat and wakaf in empowering the community's economy using a qualitative approach. This approach allows for an in-depth understanding of how zakat and wakaf can serve as effective instruments in enhancing the economic well-being of the community. The research method employed is a case study, collecting data through in-depth interviews and direct observations of institutions involved in managing zakat and wakaf, as well as their beneficiaries.
The findings indicate that zakat and wakaf play a significant role in community economic empowerment. It was found that proper management of zakat and wakaf funds can provide tangible benefits in strengthening the community's economy, especially those in low economic conditions. Targeted and transparent distribution of zakat and wakaf can also enhance community access to business capital and skills training, thereby increasing their productivity and income.

ABSTRAK
Penelitian ini bertujuan untuk mengetahui peran zakat dan wakaf dalam pemberdayaan ekonomi masyarakat dengan pendekatan kualitatif. Pendekatan ini memungkinkan untuk memahami secara mendalam bagaimana zakat dan wakaf dapat menjadi instrumen yang efektif dalam meningkatkan kesejahteraan ekonomi masyarakat. Metode penelitian yang digunakan adalah studi kasus dengan mengumpulkan data melalui wawancara mendalam dan observasi langsung terhadap lembaga-lembaga yang terlibat dalam pengelolaan zakat dan wakaf serta penerima manfaatnya. Hasil penelitian menunjukkan bahwa zakat dan wakaf memiliki peran yang signifikan dalam pemberdayaan ekonomi masyarakat. Ditemukan bahwa pengelolaan yang baik dari dana zakat dan wakaf dapat memberikan manfaat yang nyata dalam memperkuat ekonomi masyarakat, terutama yang berada dalam kondisi ekonomi rendah. Penyaluran zakat dan wakaf yang tepat sasaran dan transparan juga dapat meningkatkan akses masyarakat terhadap modal usaha dan pelatihan keterampilan, yang pada gilirannya meningkatkan produktivitas dan pendapatan mereka.
THE ROLE OF SHARIA AUDITORS IN ENSUREING COMPLIANCE OF SHARIA FINANCIAL INSTITUTIONS IN SHARIA BANK
Authors: Oktavia Saputri  , Rio Restu  , Siska Asrina  
Published: June 2024

The current development of sharia banking has encouraged the need for sharia auditors because sharia auditors have a role in sharia compliance. This research aims for sharia auditors to ensure the compliance of sharia financial institutions. This type of research uses a qualitative method, a descriptive approach with literature study data. The results of this research show that ensuring compliance of sharia financial institutions is in accordance with sharia financial concepts. Sharia auditors must have competence in the field of sharia accounting and auditing.
MANAJEMEN KEUANGAN ISLAM PERSPEKTIFF AL QUR’AN SURAT AL-BAQARAH
Authors: Alia Cahyani  , Muhammad Misbakul Munir  , Rima Hafidz Ramadhani  
Published: June 2024

Manajemen keuangan Islam telah menjadi subjek penting dalam diskusi ekonomi global, terutama dalam konteks masyarakat Muslim yang semakin beragam. Dalam upaya untuk menggali pemahaman yang lebih dalam tentang konsep-konsep manajemen keuangan dalam Islam, penelitian ini fokus pada analisis ayat-ayat yang relevan dalam Surat Al-Baqarah Al-Qur'an. Metode penelitian yang digunakan mencakup analisis tekstual yang teliti serta tinjauan terhadap literatur terkait. Hasil penelitian menunjukkan bahwa Surat Al-Baqarah Al-Qur'an menyajikan kerangka kerja yang komprehensif untuk manajemen keuangan yang berlandaskan pada prinsip-prinsip etika Islam. Salah satu prinsip utama yang diungkapkan adalah keadilan dalam pengelolaan sumber daya keuangan. Ayat-ayat yang diteliti menekankan pentingnya pembagian yang adil dari harta dan pendapatan, serta larangan terhadap riba dan praktik-praktik keuangan yang merugikan. Konsep zakat juga dijelaskan secara rinci, menggarisbawahi pentingnya berkontribusi kepada kesejahteraan sosial melalui pengeluaran yang terencana dan pemberian sumbangan kepada yang membutuhkan. Selain itu, penelitian ini mengidentifikasi prinsip-prinsip manajemen risiko yang terkandung dalam Surat Al-Baqarah. Prinsip-prinsip ini mencakup pengelolaan risiko dengan bijaksana, transparansi dalam transaksi keuangan, dan tanggung jawab sosial dalam mengelola kekayaan. Implikasi praktis dari temuan ini adalah pentingnya menerapkan prinsip-prinsip manajemen keuangan Islam dalam praktik keuangan modern. Pengembangan model-model manajemen keuangan yang sesuai dengan nilai-nilai Islam diharapkan dapat memperkuat stabilitas ekonomi dan mendukung pertumbuhan ekonomi yang inklusif di masyarakat Muslim. Penelitian ini menyiratkan perlunya kolaborasi antara para akademisi, praktisi keuangan, dan pemangku kepentingan lainnya untuk mengembangkan kerangka kerja yang lebih komprehensif dan terintegrasi untuk manajemen keuangan Islam. Dengan demikian, upaya ini diharapkan dapat memberikan kontribusi positif bagi pembangunan ekonomi yang berkelanjutan dan kesejahteraan umat manusia secara keseluruhan.
Analisis Hukum Islam Terhadap Pekerjaan Calo: Perspektif Etika Dan Dampak Sosial Ekonomi
Authors: Muklis Zakia  , Ahmad Zhofran Putra Setiawan  , Muhibban  
Published: June 2024

Penelitian ini bertujuan untuk menganalisis pekerjaan calo dalam konteks hukum Islam dengan fokus pada perspektif etika dan dampak sosial-ekonominya. Pembahasan ini penting untuk diketahui berhubung banyaknya bersinggungan terhadap fenomena yang terjadi di masyarakat khususnya dalam pekerjaan calo. Tulisan ini diharapkan dapat menjadi sumber yang digunakan untuk pertimbangan terhadap pekerjaan calo tersebut. Dalam tulisan ini berisi penjelasan tentang uraian perspektif etika, dampak sosial dan ekonomi, serta status hukumnya. Tulisan ini menggunakan metode studi literatur terhadap referensi terkemuka yang mempertimbangkan kajian tentang pekerjaan calo dari sudut pandang hukum Islam. Dalam penelitian terhadap pekerjaan calo dari perspektif hukum Islam, etika, dan dampak sosial ekonomi, disimpulkan bahwa pekerjaan calo itu hukumnya haram jika dilihat dari etika dan dampak sosial ekonominya. Serta pekerjaan calo dibolehkan jika memenuhi syarat-syarat dalam perspektif islam.
IDEJNO URBANISTIČKO REŠENJE KOMPLEKSA „7. JULI“ NA KARAĐORĐEVOM BRDU U PARAĆINU - PRIKAZ STUDENTSKIH KONKURSNIH REŠENJA
Authors: Bogdanović Protić Ivana , Ljubenović Milica , Slavković Magdalena 
Published: June 2024

U radu je dat prikaz studentskih konkursnih Idejnih urbanističkih rešenja kompleksa „7. juli“ na Karađorđevom brdu u Paraćinu. Konkurs je realizovan u organizaciji Opštine Paraćin i Katedre za urbanizam i prostorno planiranje sa Građevinsko –arhitektonskog fakulteta u Nišu u prolećnom semestru šk. 2022/2023. godine u okviru predmeta Urbanizam IV na studijskom programu Arhitektura. Proces urbanističkog projektovanja predmetne lokacije podrazumevao je: (1) analiza postojećeg stanja – potencijala i ograničenja predmetne lokacije, (2) analiza važeće planske dokumentacije za predmetnu lokaciju i njena valorizacija i (3) urbanističko-arhitektonsko rešavanje i oblikovanje prostora. Predloženim idejnim urbanističkim rešenjima planirana je transformacija lokacije u rekreativno područje multinamenskog karaktera sa smeštajnim sadržajima i komercijanim delatnostima. Dobijena rešenja, ukoliko se realizuju, mogla bi da doprinesu transformaciji lokacije u atraktivno rekreativno i turističko područje, što bi bilo od izuzetnog značaja kako za građane Paraćina, tako i za potencijalne turiste.
Evaluating Burn Injuries at the University of Sierra Leone Teaching Hospitals Complex, Freetown
Authors: Jalloh Abdulai , Kehinde Oluwadiya Sunday , EH Still Megan 
Published: June 2024

Background: As with most low- and middle-income countries (LMICs), burns are a major public health problem in Sierra Leone, yet they are poorly studied. This retrospective study of burn injuries at the Connaught Hospital unit of the University of Sierra Leone Teaching Hospitals Complex aims to bridge this gap by examining the patterns and outcomes of burn injuries over a two-year period and comparing these findings with previous studies from the same region.
Methods: A total of 146 patients were included in the study over a two-year period from January 1, 2021, to December 31, 2022.
Results: The 146 patients seen during the study period represented an average rate of 1.39 cases per week. The median age was 3.9 years (range: 2 months to 56 years) with 59.4% male involvement. Eighty percent suffered from scalds, mostly from hot water. The modal percentage of Total Body Surface Area (%TBSA) affected was 10% (range: 1–75%), and 68.1% had superficial partial thickness burns. The %TBSA of scalds was significantly smaller than that of flame burns. The most common complication was anaemia.
Conclusions: Burns continue to pose a significant challenge in Sierra Leone and the situation has not changed significantly over the past decade. There is a need to institute burn preventive measures in the country and to have dedicated functioning burns units to address this common public health problem.
Grammatical Deviations in the Lesson Plans Among Bachelor of Secondary Education (BSED) English Students
Authors: Galvez Deo J. , Celesio Marie L. 
Published: June 2024

This study sought to analyze the grammatical deviations from the collected lesson plans of BSED English students. It also describes the types and causes of grammatical deviations that occur in their lesson plans. The data were taken from the 41 collected lesson plans of BSED English students who were enrolled during the second semester of the school year 2022-2023. The qualitative-descriptive research method was used to substantially analyze the grammatical deviations within the content of the collected lesson plans. The researcher and three validators checked and reviewed the generated data to ensure that the grammatical deviations were accurately identified. The Grammatical deviations that were found in the lesson plans among BSED English students across all year levels were: subject-verb agreement and verb form. The findings revealed that subject-verb agreement had the highest occurrences of deviations due to the influence of their language transfer, which often had distinct systems and patterns, while the verb form had moderate occurrences. The findings transpire that BSED English students are not merely regarded as grammatically incompetent, just because of grammatical deviations found in their lesson plans. Nonetheless, they should be understood that their grammatical deviations are influenced and shaped by the sociolinguistic reality, language variations, and cultural backgrounds. Which can still be used as a medium in delivering the lessons, and likewise influence the learners’ academic development.
Efficacy of Plant Growth Regulators on Quality and Yield of Cucumber cv. Malini under Shade Net Conditions
Authors: Dinesh A. , Prasanth P. , Lakshminarayana D. , Nagaraju K. , Gouthami P. 
Published: June 2024

An investigation was conducted to study the effect of different plant growth regulators on quality and yield of cucumber cv. Malini under shade net conditions. The experiment was carried out with 10 treatments GA3 at 75 ppm, 150 ppm and 250 ppm, Ethrel at 100 ppm, 200 ppm and 300 ppm, Salicylic acid at 75 ppm, 150 ppm and 250 ppm and control (water spray) in 3 replications. The quality parameters like total soluble solids, texture of the fruit, Physiological loss in weight (PLW%) after harvesting and total yield harvested (q/ha) etc. were significantly influenced by plant growth regulators. Among all treatments GA3 at 250 ppm recorded with maximum fruit yield (165.17 t/ ha), Whereas for quality parameters treatment GA3 at 150 ppm found superior for total soluble solids (5.88̊ Brix) and minimum physiological loss in weight after harvesting (1 DAH, 5 DAH and 10 DAH) was recorded in GA3 at 250 ppm. And the fruits with ethrel treatment were found with smooth texture and the remaining were with rough texture.
The Impact of Digital Technology Adoption in Food Micro, Small, and Medium Enterprises: A Case Study of Borobudur Area in Indonesia
Authors: Wachyuni Suci Sandi , Priyambodo Tri Kuntoro , Hurdawaty Ramon , Kusumaningrum Dewi Ayu 
Published: June 2024

Aim: To investigate the awareness of using digital technology in Food MSMEs and understand its benefits.
Study Design: This research uses a quantitative approach with hypothesis testing.
Place and Duration of Study: The research location is in the Borobudur area, Borobudur District, Magelang Regency, Central Java, one of Indonesia's priority tourist destinations. The duration of the research study is approximately 6 months, from June to December 2023.
Methodology: This study's dependent or bound variable (Y) is Food MSME's Scaling Up in the Borobudur area. Independent or independent variables (X) are Asset Efficiency (X1), Lower Cost (X2), Quality (X3), and Safety & Sustainability (X4). Data collection was done through surveys, questionnaires, and structured observations. The number of respondents in this study was 145 respondents of local food MSMEs are in the Borobudur area, Borobudur District, Magelang Regency, Central Java. Data is tested with the Partial Least Squares Structural Equation Model (PLS-SEM) using SmartPLS version 3.
Results: The results obtained in terms of quality (QT), lower cost (LC), safety, and Sustainability (SAS) were found to have a significant impact on food MSME's scaling up (FMS). However, asset efficiency (AE) was found to have no significant impact on food MSME scaling up (FMS). This research can contribute valuable insights to guide policymakers, industry stakeholders, and MSMEs toward more effective technology adoption strategies that drive growth and resilience in an increasingly digital business landscape.
Conclusion: Quality (QT), Lower Cost (LC), Safety And Sustainability (SAS) were found to have a significant impact on food MSME's scaling up (FMS). However, asset efficiency (AE) was found to have no significant impact on food MSME's scaling up (FMS). Overcoming challenges associated with digital adoption is crucial for these businesses to thrive in a rapidly evolving business landscape.
Target Selection in Drug Discovery
Authors: Albright Charles F. 
Published: December 2011

Abstract
In this review, four criteria will be proposed to evaluate new targets: linkage to the disease, potential therapeutic index, chemical tractability, and economics. But even the best targets have issues. The ability to identify these issues, develop a plan to address these issues, and apply judgment as to the likely outcome of these issues will have a significant impact on the success of any drug discovery and development effort. Viewed from this perspective, target selection is a process not an event. In particular, as internal and external data become available, targets should be reevaluated with respect to these criteria to determine the appropriateness of continued work.
New Drug Applications
Authors: McInnes John S. 
Published: December 2011

Abstract
There are different approval processes for the different types of products that are regulated by the U.S. Food and Drug Administration (FDA). This chapter will focus on the application requirements for new human drugs, both through the new drug approval (innovator drugs) and abbreviated new drug approval (generic drugs) routes. The statutory provisions governing these requirements are found in the Federal Food, Drug, and Cosmetic Act (FDCA). Other drug application processes that will not be discussed include the over‐the‐counter review process, new animal drug applications, abbreviated new animal drug applications, and biologics license applications.
Combinatorial Compounds and Drug Discovery
Authors: Bigelow James C. 
Published: December 2011

AbstractIn this chapter, the termdrugwill be narrowed from the broad definition provided by the U.S. Food and Drug Administration to one that is more appropriate to the disciplines of pharmacology, pharmacy, and medicine. In this context, we will define a “drug” as a specific chemical species able to cause specific changes in the functioning of living things. More specifically, we will further narrow the definition to relatively small (<1500 Da) organic and occasionally inorganic compounds. By doing so, we can examine the great differences between macromolecules and the smaller, discrete organic or inorganic molecules that make up the combinatorial chemistry arena.
Aerosol Drug Delivery to the Lungs
Authors: Martin Andrew R. , Finlay Warren H. 
Published: December 2011

AbstractThis chapter will begin with a very brief introduction to aerosol mechanics as related to the transport and deposition of inhaled drug particles throughout the respiratory tract. This familiarization then will serve as requisite background for the discussion of aerosol particle sizing instruments in use for research and development, regulatory, and quality assurance purposes, as well as for descriptions of the different types of aerosol delivery systems currently available and in development.
Anti‐Inflammatory/Analgesics: An In‐Depth Look atp38MAPKinases
Authors: Brown Kelly L. 
Published: December 2011

AbstractInflammation is a complex process controlled by numerous positive and negative regulators. The p38 MAP kinase pathway is integral to the production of mediators that drive inflammation and pain and the cellular responses to these mediators. If not properly controlled, it can cause dire effects in the inflammatory, immune, and nervous systems that manifest in the development of chronic pain and inflammatory disease. As this chapter will discuss, newer versions of these molecular inhibitors must be designed in a manner that is more mindful of the complexity of p38 and the inflammatory response to reach their potential as an effective anti‐inflammatory and analgesic therapy.
Cardiology—In‐Depth Look: Advances in Antiplatelet Therapy
Authors: Mauer Karin , Saucedo Jorge F. 
Published: December 2011

AbstractAspirin, ticlopidine, clopidogrel, and IIb/IIIa inhibitors have been widely used in acute coronary syndromes (ACS) and following bare metal and drug‐eluting stent placement. Clopidogrel is superior to aspirin in reducing ischemic vascular events in high‐risk patients and has improved gastrointestinal tolerance but is associated with rash, diarrhea, and adverse hematologic outcomes. Combination antiplatelet therapy with aspirin and a thienopyridine is the optimal currently available combination following percutaneous coronary intervention (PCI) and in patients with an ACS. As this chapter will discuss, current advances in the development of new antiplatelet agents will provide a wider selection of therapeutic options for the management of cardiovascular patients.
Pharmacology of Vasopressin and the Renin–Angiotensin–Aldosterone System
Authors: Brant Elizabeth J. , Lam Albert Q. , Seifter Julian L. 
Published: December 2011

Abstract
Pharmacological agents targeted toward renal pathophysiology have had a profound effect in medicine, serving to advance the understanding of both renal disease and normal physiology, and significantly improve disease outcomes in many circumstances. A review of the mechanisms of action of several of these agents will be reviewed here. In addition, new agents active in major hormonal pathways, including antidiuretic hormone (ADH) and the rennin–angiotensin system will be introduced.
In‐Depth Look: Anti‐TNF‐α Therapies
Authors: Chatterjee Satadal , Gaddameedhi Shobhan 
Published: December 2011

AbstractToday, anti ‐tumor necrosis factor‐α (TNF‐α) drugs are being successfully used in the treatment of various inflammatory diseases such as rheumatoid arthritis (RA) and Crohn's disease. In later years, research showed that TNF‐α is involved in the progression of cancer in many other ways besides causing cancer‐associated cachexia. Anti‐TNF‐α therapy aiming to block TNF‐α, directly or indirectly, is now being investigated for treatment as well as for supportive care in cancer patients. Currently, it appears to be one of the promising approaches in resistant and nonresistant tumors as well as for cancer‐associated cachexia. This chapter will review some of the approaches being exploited to block TNF‐α and the anti‐TNF‐α drugs that have made it to clinical trials or have been approved by U.S. Food and Drug Administration (FDA) for anticancer therapy.
Thermo‐ and pH‐Responsive Polymersomes of Poly(α,β‐N‐substituted‐DL‐aspartamide)s
Authors: Hsu Shih‐Pin , Chu I‐Ming , Yang Jean‐Dean 
Published: December 2011

AbstractMaterials that can respond to multiple stimuli, such as temperature and pH changes, are of considerable interest for applications in drug delivery systems. Notably, α,β‐[poly(2‐hydroxyethyl)‐DL‐aspartamide] is a potentially useful material for such applications. This study investigated the temperature and pH responsiveness of polymers structurally similar to α,β‐[poly(2‐hydroxyethyl)‐DL‐aspartamide], namely, poly(α,β‐N‐substituted‐DL‐aspartamide)s, in aqueous media. These polymers were derived from polysuccinimide (PSI), which was first synthesized via acid‐catalyzed bulk polycondensation of L‐aspartic acid (L‐ASP) in the presence of 85% o‐phosphoric acid under N2. Two primary amino alcohols, 4‐aminobutanol (4AB) and 6‐aminohexanol (6AH), were then respectively utilized to modify PSI to form poly (α,β‐N‐substituted‐DL‐aspartamide)s via aminolysis. Different ratios of these two amino alcohols were used to modify the polymer to produce a series of copolymers with lower critical solution temperatures ranging from 53–28°C when dispersed in aqueous media. Moreover, the properties of the poly(α,β‐N‐ substituted‐DL‐aspartamide)s in aqueous solution were affected by pH changes. The morphology of the particles formed by these amphiphilic polymers was observed using scanning electronic microscopy and transmission electronic microscopy, and the particles were found to be polymersomes with shell and hollow core structures and diameters of 0.5–1 μm. Other properties of this series of self‐assembly copolymers were also characterized. © 2011 Wiley Periodicals, Inc. J Appl Polym Sci, 2012