bluuebunny/crossref_metadata_2025_split huggingface dataset:
Assessing and managing patients with borderline personality disorder requesting medical assistance in dying
Authors: Links Paul S. , Aslam Hira , Brodeur Jonah 
Published: June 2024

BackgroundWhen physician assisted dying (referred to as Medical Assistance in Dying or MAiD in this article) is available for individuals with mental disorders as the sole underlying medical condition (MD-SUMC), patients with borderline personality disorder (BPD) frequently request MAiD. Psychiatrists and other clinicians must be prepared to evaluate and manage these requests.ObjectivesThe purposes of this paper are to define when patients with BPD should be considered to have an irremediable, treatment resistant disorder and provide clinicians with an approach to assess and manage their patients with BPD making requests for MAiD.MethodsThis perspective paper developed the authors’ viewpoint by using a published, authoritative definition of irremediability and including noteworthy systematic and/or meta-analytic reviews related to the assessment of irremediability.ResultsThe clinician must be aware of the eligibility requirements for granting MAiD in their jurisdiction so that they can appropriately prepare themselves and their patients for the assessment process. The appraisal of the intolerability of the specific person’s suffering comes from having an extensive dialogue with the patient; however, the assessment of whether the patient has irremediable BPD should be more objectively and reliably determined. A systematic approach to the assessment of irremediability of BPD is reviewed in the context of the disorder’s severity, treatment resistance and irreversibility.ConclusionIn addition to characterizing irremediability, this paper also addresses the evaluation and management of suicide risk for patients with BPD undergoing the MAiD assessment process.
Age-specific risk factors of depression among the oldest-old - evidence from the multicenter AgeCoDe-AgeQualiDe study
Authors: Luppa Melanie , Pabst Alexander , Löbner Margrit , Mallon Tina , Brettschneider Christian , Hajek André , Heser Kathrin , Kleineidam Luca , Weyerer Siegfried , Werle Jochen , Pentzek Michael , Weeg Dagmar , Mösch Edelgard , Wiese Birgitt , Oey Anke , Wagner Michael , Maier Wolfgang , Scherer Martin , König Hans-Helmut , Riedel-Heller Steffi G. 
Published: June 2024

PurposeThe present study aimed to investigate age-group-specific incidence rates and risk factors for depressive symptoms in the highest age groups.MethodsData were derived from a prospective multicenter cohort study conducted in primary care – the AgeCoDe/AgeQualiDe study. In total, 2,436 patients 75 years and older were followed from baseline to ninth follow-up. To assess depressive symptoms, the short version of the Geriatric Depression Scale (GDS-15, cutoff score 6) was used. Age-specific competing risk regressions were performed to analyze risk factors for incident depressive symptoms in different age groups (75 to 79, 80 to 84, 85+ years), taking into account the accumulated mortality.ResultsThe age-specific incidence rate of depression was 33 (95% CI 29-38), 46 (95% CI 40-52) and 63 (95% CI 45-87) per 1,000 person years for the initial age groups 75 to 79, 80 to 84 and 85+ years, respectively. In competing risk regression models, female sex, mobility as well as vision impairment, and subjective cognitive decline (SCD) were found to be risk factors for incident depression for age group 75 to 79, female sex, single/separated marital status, mobility as well as hearing impairment, and SCD for age group 80 to 84, and mobility impairment for age group 85+.ConclusionDepressive symptoms in latest life are common and the incidence increases with increasing age. Modifiable and differing risk factors across the highest age groups open up the possibility of specifically tailored prevention concepts.
Association of four metalloids in the serum and urine of individuals with major depressive disorders: a case–control study
Authors: He Lei , Li Shilong , Huang Yan , Zhu Yuxing , Fan Lingzi , Zhang Hongwei , Hou Xiaofang , Li Xiaoxin , Deng Hongxin , Guo Xueli , Liu Chunxiao , Hu Chen , Cao Bing 
Published: June 2024

BackgroundMajor depressive disorder (MDD) pathogenesis may involve metalloids in a significant way. The aim of our study was to identify potential links between MDD and metalloid elements [boron (B), germanium (Ge), arsenic (As), antimony (Sb)].MethodsA total of 72 MDD cases and 75 healthy controls (HCs) were recruited from Zhumadian Second People’s Hospital in Henan Province, China. The levels of four metallic elements (B, Ge, As, and Sb) in the serum and urine were measured using inductively coupled plasma mass spectrometry (ICP-MS).ResultsIn comparison to the HCs, the B, As, and Sb levels were considerably lower in the MDD group (p &lt; 0.05) in the serum; the MDD group had significantly higher (p &lt; 0.05) and significantly lower (p &lt; 0.001) B and Sb levels in the urine. After adjusting for potential confounders, serum B (OR = 0.120; 95% CI, 0.048, 0.300; p &lt; 0.001) and Sb (OR = 0.133; 95% CI, 0.055, 0.322; p &lt; 0.001) showed a negative correlation with MDD. Urine B had a negative correlation (OR = 0.393; 95% CI, 0.193, 0.801; p = 0.01) with MDD, while urine Sb had a positive correlation (OR = 3.335; 95% CI, 1.654, 6.726; p = 0.001) with MDD. ConclusionOur current research offers insightful hints for future investigation into the function of metalloids in connection to MDD processes.
Self-perceived relations between artistic creativity and mental illness: a study into lived experiences
Authors: Boumans Jenny , Oderwald Arko , Kroon Hans 
Published: June 2024

AimTo explore the self-perceived relationships between experiences of creativity and mental illness and to understand the meanings behind these relationships.BackgroundThe idea that mental illness and artistic creativity are somehow related dates back to ancient times. There is some evidence for an actual correlation, but many questions remain unanswered on the nature and direction of the relationship. Qualitative contributions to the debate are scarce, and mainly focus on the potential benefits of participation in the arts for people with mental illness.DesignAn explorative, interpretive study.MethodsTwenty-four professional and semi-professional artists with self-reported experience with mental illness, were recruited purposively. Unstructured in-depth interviews were conducted and transcripts were subjected to interpretive analysis, guided by a hermeneutic phenomenological frame.ResultsParticipants experience a range of interactions between artistic creativity and mental illness. Three constitutive patterns describe what these interactions look like: “flow as a powerful force”; “ambiguous self-manifestation”; and “narrating experiences of suffering.”ConclusionThe findings show that both the concept of creativity and the concept of mental illness, as well as their interrelationships, are layered and complex phenomena that can take on different meanings in people’s lives. The findings provide starting points for further research that goes beyond the polarized academic debate. Understanding the experiences of artists with mental illness can help shape the role of art in public mental health and mental health care.
Exploring the relationship between older adults’ online health information seeking, negative emotions and prevention behaviors in the pandemic context: a two-wave longitudinal study
Authors: Liu Tianchang , Song Xiaokang , Zhu Qinghua 
Published: June 2024

IntroductionDuring the COVID-19 pandemic, older adults were facing more mental health issues that may cause complex impacts on pandemic prevention, and turning to the internet for health information is a double-edged sword for them. This study aimed to investigate the reciprocal relationship between negative emotions and prevention behaviors in older adults, as well as the direct and moderating effects of online health information seeking (OHIS) on negative emotions and prevention behaviors.MethodsBased on the common-sense model of self-regulation (CSM) and a sample of more than 20,000 participants from the Survey of Health, Aging and Retirement in Europe (SHARE), this study first used an autoregressive cross-lagged panel model (CLPM) to analyze the longitudinal effect of negative emotions on prevention behaviors. Second, the study used ordinary least squares (OLS) regression to explore the influence of OHIS usage frequency changes on negative emotions and prevention behaviors. Third, the study used multigroup analysis to examine the moderating effect of OHIS usage frequency changes on the CLPM.ResultsThe findings indicate a significant longitudinal association where initial negative emotions predicted later prevention behaviors (β = 0.038, p &lt; 0.001), and increased OHIS frequency was linked to positive changes in prevention behavior (β = 0.109, p &lt; 0.001). Multigroup analysis revealed that the connection between negative emotions or increased negative emotions and prevention behaviors remained significant for those with no change or an increase in OHIS frequency but not for those with a decrease.ConclusionThis study suggested that negative emotions may drive older adults to engage more in prevention behaviors and that OHIS can augment this effect. These results underscore the importance of addressing mental health and providing reliable online health information to support older adults in managing infectious disease risks.
Injection preparation filtration and health concerns among indigenous people who inject methamphetamine
Authors: Anastario Michael , Suarez Andrea , Williamson Olivia , Firemoon Paula , Roberts Elizabeth F. S. , Barber Jarrett 
Published: June 2024

IntroductionInjecting methamphetamine poses significant health risks, but little is known about how methamphetamine injectors filter their injection preparations and experience related health concerns.MethodsA chain-referral sample of Indigenous people who inject methamphetamine (n = 30) was recruited and semistructured interviews were conducted to collect information on filtration practices and health concerns.ResultsFiltration of the injection preparation was described by 53% of injectors. Elevated levels of concern for kidney disease, cancer and heart disease were observed among those who filtered their preparations (ranging from 50 to 56.3%). Concern about liver disease was the most frequent concern among those who filtered their preparations (62.5%) and was elevated in comparison to those who did not use filters (7.1%). Grouped logistic regression revealed a positive association between filtration of the injection preparation and overall health concerns expressed by injectors, after adjusting for gender and age. The marginal posterior distribution of the adjusted odds ratio for filtration of the injection preparation had a posterior median = 35.7, and 95% HPD interval = (5.1, 512.4).DiscussionResults illustrate a positive relationship between filtration of the injection preparation and health concerns among Indigenous people who inject methamphetamine. This likely reflects the use of filtration to reduce harms, and further research is needed to understand the full scope of prevention that may be associated with filtration of methamphetamine injection preparations.
Correlations between empathy fatigue, occupational identity, and sleep quality in nursing staff: a cross-sectional study
Authors: Zhao Yingying , Wang Xin , Liu Tao 
Published: June 2024

ObjectiveTo investigate the status quo of empathic fatigue, professional identity, and sleep quality of nursing staff in nursing institutions. To analyze the correlation between empathic fatigue, professional identity and sleep quality of nursing staff.MethodsThis is a cross-sectional study. The method of convenient sampling was used to select 224 nursing workers from the older adult's institutions in the Panjin area as the investigation objects. The nurses' general data questionnaire, the Chinese version of the compassion fatigue short scale, the nurses' professional identity Scale, and the Pittsburgh Sleep Quality Index were used as evaluation tools. SPSS26.0 statistical software was used to sort out and analyze the data.ResultsThere was a positive correlation between empathic fatigue and sleep quality; there was a negative correlation between empathy fatigue and professional identity. Occupational identity and sleep quality were negatively correlated.ConclusionThere is a correlation between empathic fatigue, professional identity, and sleep quality of nursing workers. Empathy fatigue is positively correlated with sleep quality. Empathy fatigue was negatively correlated with professional identity. Occupational identity was negatively correlated with sleep quality. To provide a theoretical basis for the management of older adult's nursing staff and the formulation of corresponding management systems and policies, promote the mental health of older adult's nursing staff, improve sleep quality, and provide a theoretical basis and reference for future intervention research.
Vigorous physical activity and weight status in school-aged children: a cross-sectional study
Authors: Yu Weijun , Xu Shuanglu , Dai Xiaojie , Fan Huiying 
Published: June 2024

AimTo explore the association between VPA and weight status in adolescents.MethodsThe 2017/2018 Health Behavior in School-aged Children survey (HBSC) targeted children and adolescents aged 11, 13 and 15. A systematic multistage stratified cluster randomized sampling method was used in each participating country. The 2017/2018 survey enrolled over 240,951 adolescents across 45 countries and regions. Frequency of VPA, weight status and confounding factors were collected using a self-reported questionnaire.ResultsCompared to daily VPA, less frequent VPA was linked to higher odds of obesity. For example, those who participating in VPA for 4–6 times a week (OR = 1.10, 95% CI = 1.06–1.13), 2–3 times a week (OR = 1.21, 95% CI = 1.17–1.25), or once a week (OR = 1.21, 95% CI = 1.16–1.25) all have higher odds of abnormal weight status. For boys, the frequency of 4–6 times a week (OR = 1.09, 95% CI = 1.04–1.13), 2–3 times a week (OR = 1.22, 95% CI = 1.17–1.27), or once a week (OR = 1.25, 95% CI = 1.19–1.32) were associated with higher odds of abnormal weight status. For girls, those who participating in VPA 4–6 times a week (OR = 1.11, 95% CI = 1.06–1.16), 2–3 times a week (OR = 1.20, 95% CI = 1.14–1.25), or once a week (OR = 1.17, 95% CI = 1.11–1.23) all have higher odds of abnormal weight status (i.e., overweight or obesity).ConclusionThis population-based study suggests that infrequent VPA participation is associated with unhealthy weight status in adolescents compared to their physically active counterparts. Additionally, this association remains consistent in both boys and girls.
SoCap YMH – youth mental health, social capital and help-seeking: a study protocol
Authors: Ahlborg Mikael G. , Morgan Antony , Svedberg Petra , Nygren Jens M. , Eriksson Malin , Westberg Katrin Häggström 
Published: June 2024

BackgroundThe increase in adolescents reporting mental health problems presents a major public health challenge. The complex association between mental health and social capital motivates further investigation of social capital as a crucial aspect in shaping adolescents’ help-seeking knowledge, attitudes, and behaviours.AimThis protocol presents a project that aims to investigate social capital in relation to help-seeking and mental health in close collaboration with adolescents and key stakeholders in the school setting, in the southern part of Sweden.MethodsA mixed-method design with three interconnected work packages (WP) will be undertaken with an emphasis on co-production where adolescents are involved throughout the process. WP1 is a development and validation of two questionnaire instruments for assessing social capital and help-seeking in adolescence. WP2 is a longitudinal quantitative study involving 1,500 adolescents from two regions representing rural and suburban/urban settings. Adolescents aged 15 will be asked to complete questionnaires concerning social capital, mental health, and help-seeking in a baseline and one-year follow-up, allowing for investigation of the role of social capital for help-seeking. WP3 is designed to elucidate experiences and knowledge of adolescents and key stakeholders via collaborative World Café workshops. These will be held along the project to evolve the generated knowledge and maximize it’s applicability during and after the project is finalized.ConclusionThe results are expected to further the understanding of the relationship between adolescents’ social capital, mental health, and help-seeking, to contribute to a deeper understanding of the mechanisms behind the paradoxical help-seeking patterns among adolescents today and to narrow the gap between research and practice to produce sustainable and efficient strategies, which may facilitate help-seeking and improve the mental health of adolescents within existing organizational structures.
Implementing neuropsychological rehabilitation following severe traumatic brain injury in a low-to-middle income country: a case report
Authors: Soule Alexa Caitlin , Fish Taryn Jane , Winegardner Jill , Schrieff-Brown Leigh 
Published: June 2024

IntroductionTBI incidence and distribution are largely overrepresented in low- to middle-income countries (LMICs), such as South Africa (SA), with substantial associated human and financial costs. However, access to rehabilitation for the public is severely limited and not standard practice in SA. Given this background, studies demonstrating the successful implementation of neuropsychological rehabilitation in a LMIC setting are important. Published studies of this nature are generally lacking in this context. Further, there is a need to evaluate interventions that can be implemented at a low cost. To this end, we report on a neuropsychological rehabilitation program for an individual with severe TBI in a LMIC context, aimed at improving his capacity for activities of daily living.MethodA 33-year-old, South African male who sustained a severe traumatic brain injury (TBI) partook in a neuropsychological intervention aimed at remediating functional deficits and enhancing independent functioning. The intervention utilised principles of Goal Management Training and external memory aids, with reliance on procedural memory and errorless learning, to target the participant's impairments in executive functioning and memory through the use of assistive technology—namely smart device applications.ResultsData collected pre- and post-intervention on formal neuropsychological measures demonstrated no significant change in cognition. However, observational data and qualitative feedback from the participant's family indicated notable improvement in performance on everyday tasks with reduced number of errors and reduced need for external prompting whilst completing intervention tasks across sessions.DiscussionIn the context of severe TBI, neuropsychological rehabilitation can facilitate gains in independent functioning. This study provides support for the value of neurorehabilitation especially for interventions that can be rolled out at low cost and should serve as impetus for further such research in South Africa, where neuropsychological rehabilitation infrastructure and services are lacking.
Interactions of TTV with BKV, CMV, EBV, and HHV-6A and their impact on post-transplant graft function in kidney transplant recipients
Authors: Rosiewicz Kamil S. , Blazquez-Navarro Arturo , Kaliszczyk Sviatlana , Bauer Chris , Or-Guil Michal , Viebahn Richard , Zgoura Panagiota , Reinke Petra , Roch Toralf , Hugo Christian , Westhoff Timm , Thieme Constantin , Stervbo Ulrik , Babel Nina 
Published: June 2024

BackgroundMono and combined reactivation of latent viruses occurs frequently under immunosuppressive therapy in kidney transplant patients. Recently, monitoring torque teno virus (TTV) reactivation came more into focus as a potential biomarker for immune status. The surrogate characteristics of TTV reactivation on acute rejection, and the combined reactivation with other latent viruses such as cytomegalovirus (CMV), human BK virus (BKV), Epstein–Barr virus (EBV), and human herpes virus-6A (HHV-6A) on allograft function, are unknown so far.MethodsBlood samples from 93 kidney transplant recipients obtained during the first post-transplant year were analyzed for TTV/BKV/CMV/EBV/HHV-6A load. Clinical characteristics, including graft function [glomerular filtration rate (GFR)], were collected in parallel.ResultsTTV had the highest prevalence and viral loads at 100% and a mean of 5.72 copies/ml (cp/ml) (log10). We found 28.0%, 26.9%, 7.5%, and 51.6% of simultaneous reactivation of TTV with BKV, CMV, EBV, and HHV-6, respectively. These combined reactivations were not associated with a significantly reduced estimated GFR at month 12. Of interest, patients with lower TTV loads &lt;5.0 cp/ml (log10) demonstrated not only a higher incidence of acute rejection, but also an unexpected significantly earlier occurrence and higher incidence of BKV and HHV-6A reactivation. Correlations between TTV loads, other latent viruses, and immunosuppressive medication were only significant from 6 months after transplant.ConclusionWe were able to observe and support previously introduced TTV load thresholds predicting kidney allograft rejection. However, due to a possible delayed relation between immunosuppressive medication and TTV viral load adaptation, the right time points to start using TTV as a biomarker might need to be further clarified by other and better designed studies.
Exploring the Roles of TALE Gene Family in Maize Drought Stress Responses
Authors: Qian Buxuan , Wang Qi , Zhang Chuang , Guo Jia , Yu Zhijia , Han Jiarui , Xia Hanchao , Zhao Rengui , Yin Yuejia 
Published: June 2024

The TALE gene family plays a crucial role in regulating growth, development, and abiotic stress responses in plants. However, limited studies have been conducted on the functions of the ZmTALE gene family in maize under drought stress. This study identified 40 members of the ZmTALE family within the maize genome through Blast comparisons, distributed unevenly across the first nine chromosomes. Intraspecific collinearity analysis revealed 13 linked pairs. By constructing a phylogenetic tree with Arabidopsis AtTALE members as references, maize members were divided into two subfamilies, KNOX and BEL1-Like, with KNOX further divided into three branches (KNOX Class I, KNOX Class II, and KNOX Class III). The gene structure and motifs of ZmTALE genes within the same subfamily or branch showed similarities, as did their encoded proteins, which possess similar motifs and conserved domains. Analysis of the physicochemical properties of the ZmTALE proteins revealed that the proteins encoded by this family are stable. Expression analysis of ZmTALE genes in maize demonstrated their varied roles in development and drought stress regulation, confirmed through qRT-PCR. The identification, characterization, and expression analysis of ZmTALE genes provide a reference for future gene function research and aid in the genetic enhancement of maize to withstand drought stress.