bluuebunny/crossref_metadata_2025_split huggingface dataset:
VCD spectroscopic properties of the β‐hairpin forming miniprotein CLN025 in various solvents
Authors: Hatfield Marcus P. D. , Murphy Richard F. , Lovas Sándor 
Published: November 2009

AbstractElectronic and vibrational circular dichroism are often used to determine the secondary structure of proteins, because each secondary structure has a unique spectrum. Little is known about the vibrational circular dichroic spectroscopic features of the β‐hairpin. In this study, the VCD spectral features of a decapeptide, YYDPETGTWY (CLN025), which forms a stable β‐hairpin that is stabilized by intramolecular weakly polar interactions and hydrogen bonds were determined. Molecular dynamics simulations and ECD spectropolarimetry were used to confirm that CLN025 adopts a β‐hairpin in water, TFE, MeOH, and DMSO and to examine differences in the secondary structure, hydrogen bonds, and weakly polar interactions. CLN025 was synthesized by microwave‐assisted solid phase peptide synthesis with Nα‐Fmoc protected amino acids. The VCD spectra displayed a (−,+,−) pattern with bands at 1640 to 1656 cm−1, 1667 to 1687 cm−1, and 1679 to 1686 cm−1 formed by the overlap of a lower frequency negative couplet and a higher frequency positive couplet. A maximum IR absorbance was observed at 1647 to 1663 cm−1 with component bands at 1630 cm−1, 1646 cm−1, 1658 cm−1, and 1675 to 1680 cm−1 that are indicative of the β‐sheet, random meander, either random meander or loop and turn, respectively. These results are similar to the results of others, who examined the VCD spectra of β‐hairpins formed by DPro‐Xxx turns and indicated that observed pattern is typical of β‐hairpins. © 2009 Wiley Periodicals, Inc. Biopolymers 93: 442–450, 2010.This article was originally published online as an accepted preprint. The “Published Online” date corresponds to the preprint version. You can request a copy of the preprint by emailing the Biopolymers editorial office at biopolymers@wiley.com
Keeping psychotherapy notes separate from the patient record
Authors: DeLettre Julie L. , Sobell Linda Carter 
Published: November 2009

AbstractDoctoral level psychologists (N = 464) who were members of the American Psychological Association and who identified themselves as clinical practitioners were surveyed about their knowledge and utilization of the Health Insurance Portability and Accountability Act (HIPAA) Privacy Rule that allows practitioners to keep their psychotherapy notes separate from their patients' records if they involve electronic submissions. Although 79% of those surveyed said they were aware of the HIPAA privacy rule allowing for a separate set of notes, slightly less than half (46%) reported currently using such notes even though half (49%) felt that patients benefit most from the use of a separate set of psychotherapy notes. Surprisingly, 21% said they had never heard of the HIPAA provision allowing for a separate set of notes. Considering that when this provision was introduced it was heralded as a major benefit for mental health practitioners, its low utilization is surprising. Perhaps clinical practitioners would benefit from continuing education about the benefits of such notes. Copyright © 2009 John Wiley & Sons, Ltd.Key Practitioner Message:

There can be some value to keeping psychotherapy notes apart from the patient's record.
Seventy‐nine per cent of psychologists in the USA who were surveyed were aware that they could keep a separate set of notes.
Less than half (46%) of those who were aware of this provision actually kept a second set of notes.
When asked, half said the benefit of keeping such a set of notes was for their patients.
An investigation into the relationship between attachment, gender and recovery from psychosis in a stable community‐based sample
Authors: Mulligan Alison , Lavender Tony 
Published: November 2009

AbstractThe current study sought to investigate how men and women who experience psychosis represent early bonding experiences, current attachment style and the recovery style adopted. Seventy‐three participants (18 women and 55 men) with a diagnosis of psychosis completed the Parental Bonding Instrument, the Attachment Style Questionnaire and the Recovery Style Questionnaire. Differences were observed between men and women in relation to the nature of insecure attachment styles demonstrated. Significant associations were found between perceptions of parents as uncaring and insecurity in adult attachment style. A greater number of significant associations were found between recollections of early bonding and attachment styles amongst women than men. Men and women did not differ significantly in terms of the recovery style adopted, nor were significant differences found in relation to perceptions of early bonding experiences. Methodological and theoretical issues were considered and directions for future research were suggested. Copyright © 2009 John Wiley & Sons, Ltd.Key Practitioner Message:

Individuals with psychosis are more likely to have lower levels of parental care than the general population.
This lower parental care is likely to be associated with insecure adult attachment relationships but not recovery style.
Exploring the personal and professional impact of reflective practice groups: a survey of 18 cohorts from a UK clinical psychology training course
Authors: Knight Katherine , Sperlinger David , Maltby Michael 
Published: November 2009

AbstractObjectives: Given the importance of reflective practice within clinical psychology and a lack of empirical research, this study aimed to investigate the personal and professional impact of reflective practice groups (RPGs) for former trainees.Design: This study followed an analytic survey design utilizing a convenience sample of qualified clinical psychologists from a UK training programme.Methods: A RPG questionnaire (RPGQ) was developed for the purposes of the study. Following initial pilot work, 297 qualified psychologists were invited to complete the RPGQ.Results: One hundred and twenty‐four psychologists (42%) completed the RPGQ. Factor analysis yielded two underlying constructs labelled ‘value’ and ‘distress’. The RPGQ demonstrated significant internal and test–retest reliability. The majority rated the RPGs as valuable for personal and professional development and learning about group processes. Just under half however reported distress as a result of the groups. Whilst some trainees, who reported distress, were able to view the challenges positively, one‐sixth were not. Potency of facilitation and group size significantly predicted levels of perceived value and distress.Conclusions: In view of the ethical issues raised by compulsory RPGs, recommendations were made to keep group sizes within an average of 10–13, utilize facilitators with sufficient training in group processes and ensure additional methods of reflective practice development are available. Further suggestions and recommendations for future research in relation to coping and personal learning style were also made. Copyright © 2009 John Wiley & Sons, Ltd.Key Practitioner Message:

This study has addressed a significant gap in the clinical psychology literature in relation to the personal and professional impact of reflective practice groups during training.
It was found that whilst, in retrospect, the majority of former trainees found the challenges of reflective practice groups worthwhile, a significant minority did not.
Group size, potency of facilitation and previous RPG experience significantly predicted levels of perceived value and distress.
There is now a need for more research in order to explore the mechanisms involved to maximize potential for value from reflective practice groups.
Business students' perception of corporate social responsibility: the United States, China, and India
Authors: Wong Alan , Long Fu , Elankumaran S. 
Published: November 2009

AbstractThis study used a questionnaire to assess perceptive differences in corporate social responsibility among business students in the United States, China, and India. The study finds that American and Indian respondents attached more importance to the noneconomic aspects of social responsibility than Chinese respondents. Chinese students were more accepting of making facilitating payments to get things moving. Indian respondents placed more emphasis on philanthropy while the US group emphasized legal obligations. In the choice of business goals, there is generally little difference between the three nationality groups. The two main goals selected are taking care of owners' interests and consumers' needs. The study's findings have implications for business school curriculum, public policy, and multinational corporations. Copyright © 2009 John Wiley & Sons, Ltd and ERP Environment.
Pulmonary neuroendocrine neoplasms: A review of clinicopathologic and cytologic features
Authors: Siddiqui Momin T. 
Published: November 2009

AbstractNeuroendocrine tumors form a distinct group of lung neoplasms sharing characteristic cytohistologic, immunohistochemical, ultrastructural, and molecular features. The objective of this review article is to discuss the diagnostic classifications and the morphologic cytologic–histologic features for the different categories of neuroendocrine tumors of the lung. An accurate characterization of the neuroendocrine tumors of the lung requires knowledge of specific criteria separating the major categories, which is highly essential for determining prognosis and treatment options for these patients. Diagn. Cytopathol. 2010;38:607–617. 2009 Wiley‐Liss, Inc.
Visual discrimination of male and female faces by infant rhesus macaques
Authors: Paukner Annika , Huntsberry Mary E. , Suomi Stephen J. 
Published: November 2009

AbstractRecent studies have revealed that human infants process female faces differently from male faces. To test whether a similar preference for female faces exists in other primates, we presented nursery‐reared infant rhesus macaques with photographs of macaque faces and human faces. At <1 month old, infant macaques preferentially oriented towards female macaque faces when faces were presented upright. No preference for female human faces was found. At 9 months old, infants failed to show a visual preference for female macaque faces or female human faces, although they showed significantly more lipsmacking responses at female human faces. Compared to human infants, macaques appear to have stronger predispositions early in life but this preference may nonetheless be amendable to experience. Understanding how innate predispositions and the social rearing environment shape infants' understanding of faces remain important issues to be explored in order to understand facial processing abilities in humans and other primates. © 2009 Wiley Periodicals, Inc. Dev Psychobiol 52: 54–61, 2010
The effects of stress on play and home cage behaviors in adolescent male rats
Authors: Klein Zoe A. , Padow Victoria A. , Romeo Russell D. 
Published: November 2009

AbstractOne prominent feature of adolescence is the high frequency of social behaviors, such as play. Engaging in these behaviors appears necessary for proper socio‐emotional development as social isolation during adolescence typically leads to behavioral dysfunctions in adulthood. The present experiments examined the effects of stress on social and nonsocial behaviors in group housed adolescent male rats. We found that acute restraint stress led to a complete inhibition of play (e.g., nape contacts and pins) and reduced social investigations in pre‐ (28 days), mid‐ (35 days), and late‐adolescent (42 and 49 days) animals. A follow‐up study, however, found that restraint‐induced suppression of play and social investigations was transient such that experimental animals engage in these behaviors at levels similar to those of controls 1 hr after termination of the stressor. We also found that exposure to repeated restraint stress throughout adolescence led to a decrease in social investigations, while leaving play largely unaffected. Interestingly, in all of the experiments, nonsocial behaviors (e.g., eating, drinking, grooming) were unaffected by restraint, suggesting these effects of stress are specific to social behaviors. Together, these data indicate that both acute and repeated stress significantly affect social behaviors during adolescence. © 2009 Wiley Periodicals, Inc. Dev Psychobiol 52: 62–70, 2010
Change in imitation for object manipulation between 10 and 12 months of age
Authors: Fagard Jacqueline , Lockman Jeffrey J. 
Published: November 2009

AbstractBy the end of the first year, infants show dramatic increases in manual skill. In this study we tested one factor likely to contribute to this change: an increase in the capacity for observational learning, which may enable infants to learn new behaviors and practice ones that they already possess. Thus, we evaluated change in imitation between 10 and 12 months of age. Twelve 10‐month‐olds and twelve 12‐month‐old infants were shown different kinds of manual actions on a variety of objects; infants also manipulated objects during a free play control condition. Results indicated that older infants benefited more than younger ones in the Demonstration condition and that at both ages, infants performed the target action more quickly after observing a demonstration. We hypothesize that observational learning can help manual skill development by enabling infants to learn new actions and select and practice ones already in their skill set. © 2009 Wiley Periodicals, Inc. Dev Psychobiol 52: 90–99, 2010
Multiple mechanisms mediate motor neuron migration in the zebrafish hindbrain
Authors: Bingham Stephanie M. , Sittaramane Vinoth , Mapp Oni , Patil Shekhar , Prince Victoria E. , Chandrasekhar Anand 
Published: November 2009

AbstractThe transmembrane protein Van gogh‐like 2 (Vangl2) is a component of the noncanonical Wnt/Planar Cell Polarity (PCP) signaling pathway, and is required for tangential migration of facial branchiomotor neurons (FBMNs) from rhombomere 4 (r4) to r5‐r7 in the vertebrate hindbrain. Since vangl2 is expressed throughout the zebrafish hindbrain, it might also regulate motor neuron migration in other rhombomeres. We tested this hypothesis by examining whether migration of motor neurons out of r2 following ectopic hoxb1b expression was affected in vangl2− (trilobite) mutants. Hoxb1b specifies r4 identity, and when ectopically expressed transforms r2 to an “r4‐like” compartment. Using time‐lapse imaging, we show that GFP‐expressing motor neurons in the r2/r3 region of a hoxb1b‐overexpressing wild‐type embryo migrate along the anterior‐posterior (AP) axis. Furthermore, these cells express prickle1b (pk1b), a Wnt/PCP gene that is specifically expressed in FBMNs and is essential for their migration. Importantly, GFP‐expressing motor neurons in the r2/r3 region of hoxb1b‐overexpressing trilobite mutants and pk1b morphants often migrate, even though FBMNs in r4 of the same embryos fail to migrate longitudinally (tangentially) into r6 and r7. These observations suggest that tangentially migrating motor neurons in the anterior hindbrain (r1‐r3) can use mechanisms that are independent of vangl2 and pk1b functions. Interestingly, analysis of tri; val double mutants also suggests a role for vangl2‐independent factors in neuronal migration, since the valentino mutation partially suppresses the trilobite mutant migration defect. Together, the hoxb1b and val experiments suggest that multiple mechanisms regulate motor neuron migration along the AP axis of the zebrafish hindbrain. © 2009 Wiley Periodicals, Inc. Develop Neurobiol, 2010
Drosophila growth cones: A genetically tractable platform for the analysis of axonal growth dynamics
Authors: Sánchez‐Soriano Natalia , Gonçalves‐Pimentel Catarina , Beaven Robin , Haessler Ulrike , Ofner‐Ziegenfuss Lisa , Ballestrem Christoph , Prokop Andreas 
Published: November 2009

AbstractThe formation of neuronal networks, during development and regeneration, requires outgrowth of axons along reproducible paths toward their appropriate postsynaptic target cells. Axonal extension occurs at growth cones (GCs) at the tips of axons. GC advance and navigation requires the activity of their cytoskeletal networks, comprising filamentous actin (F‐actin) in lamellipodia and filopodia as well as dynamic microtubules (MTs) emanating from bundles of the axonal core. The molecular mechanisms governing these two cytoskeletal networks, their cross‐talk, and their response to extracellular signaling cues are only partially understood, hindering our conceptual understanding of how regulated changes in GC behavior are controlled. Here, we introduce Drosophila GCs as a suitable model to address these mechanisms. Morphological and cytoskeletal readouts of Drosophila GCs are similar to those of other models, including mammals, as demonstrated here for MT and F‐actin dynamics, axonal growth rates, filopodial structure and motility, organizational principles of MT networks, and subcellular marker localization. Therefore, we expect fundamental insights gained in Drosophila to be translatable into vertebrate biology. The advantage of the Drosophila model over others is its enormous amenability to combinatorial genetics as a powerful strategy to address the complexity of regulatory networks governing axonal growth. Thus, using pharmacological and genetic manipulations, we demonstrate a role of the actin cytoskeleton in a specific form of MT organization (loop formation), known to regulate GC pausing behavior. We demonstrate these events to be mediated by the actin‐MT linking factor Short stop, thus identifying an essential molecular player in this context. © 2009 Wiley Periodicals, Inc. Develop Neurobiol 2010
Limitations of European Union policy and law for regulating use of lead shot and sinkers: comparisons with North American regulation
Authors: Thomas Vernon G. , Guitart Raimon 
Published: November 2009

AbstractExtensive shooting and angling causes, indirectly, fatal lead poisoning of birds. European Union policy on this major source of pollution is inconsistent with its laws regulating other forms of lead in the environment. Only three countries have banned the use of lead shot completely in the European Union, despite availability of substitutes and evidence that their use is a major contributor to bird conservation. The European Commission uses the criterion of amount of lead deposited and corroded, and the concentration of lead in water and soil, as the basis of their decisions. The USA and Canada used the prevalence of lead poisoning among birds as the basis of policy and law allowing them to reduce lead use at the continental level. The EU and North American policies and law on lead reduction are compared in this study, on the basis of which recommendations are developed indicating how the EU could revise its approach and resolve this environmental problem. Reluctance to act on lead reduction by the European Parliament and its member states reflects the current vested interests of the sporting communities. Companies in eight European countries already produce non‐toxic materials for hunting and shooting, and are not the limiting factor in this issue. Copyright © 2009 John Wiley & Sons, Ltd and ERP Environment.
Measurement of IPTV traffic from an operative network
Authors: Mellia Marco , Meo Michela 
Published: November 2009

AbstractIn this paper, we present measurement results of IP TeleVision (IPTV) multicast traffic collected from real of the FastWeb network. FastWeb is an ISP provider, which is the main broadband telecommunication company in Italy. The network relies on an IP architecture and, besides television channels, delivers to the user services such as data transfer and VoIP over a single broadband connection. The traffic we focus on consists of 83 high‐quality digital TV channels encoded using different MPEG‐2 encoders. The results show that, depending on the encoder and based on the bitrate, flows can be classified as being: 1‐VBR, i.e. with one typical value of the mean bit rate, 2‐VBR, i.e. two typical bitrate values are observed, and VBR. Measurement of the packet loss, jitter and inter‐packet gap show that, independently from the class, packet generation process of the flows can have various degrees of burstiness. Despite the packet level burstiness, average jitter is limited to few milliseconds and no packet loss was ever observed in the backbone. Moreover, the evolution of inter‐packet gap over time remains basically unchanged when observing a flow in different time periods. Our results prove that the FastWeb network is properly carrying IPTV traffic, and that today technology is mature to make TV over IP feasible and of good quality. Copyright © 2009 John Wiley & Sons, Ltd.
Neuronal network pharmacodynamics of GABAergic modulation in the human cortex determined using pharmaco‐magnetoencephalography
Authors: Hall Stephen D. , Barnes Gareth R. , Furlong Paul L. , Seri Stefano , Hillebrand Arjan 
Published: November 2009

AbstractNeuronal network oscillations are a unifying phenomenon in neuroscience research, with comparable measurements across scales and species. Cortical oscillations are of central importance in the characterization of neuronal network function in health and disease and are influential in effective drug development. Whilst animal in vitro and in vivo electrophysiology is able to characterize pharmacologically induced modulations in neuronal activity, present human counterparts have spatial and temporal limitations. Consequently, the potential applications for a human equivalent are extensive. Here, we demonstrate a novel implementation of contemporary neuroimaging methods called pharmaco‐magnetoencephalography. This approach determines the spatial profile of neuronal network oscillatory power change across the cortex following drug administration and reconstructs the time course of these modulations at focal regions of interest. As a proof of concept, we characterize the nonspecific GABAergic modulator diazepam, which has a broad range of therapeutic applications. We demonstrate that diazepam variously modulates θ (4–7 Hz), α (7–14 Hz), β (15–25 Hz), and γ (30–80 Hz) frequency oscillations in specific regions of the cortex, with a pharmacodynamic profile consistent with that of drug uptake. We examine the relevance of these results with regard to the spatial and temporal observations from other modalities and the various therapeutic consequences of diazepam and discuss the potential applications of such an approach in terms of drug development and translational neuroscience. Hum Brain Mapp, 2010. © 2009 Wiley‐Liss, Inc.
Association of trait emotional intelligence and individual fMRI‐activation patterns during the perception of social signals from voice and face
Authors: Kreifelts Benjamin , Ethofer Thomas , Huberle Elisabeth , Grodd Wolfgang , Wildgruber Dirk 
Published: November 2009

AbstractMultimodal integration of nonverbal social signals is essential for successful social interaction. Previous studies have implicated the posterior superior temporal sulcus (pSTS) in the perception of social signals such as nonverbal emotional signals as well as in social cognitive functions like mentalizing/theory of mind. In the present study, we evaluated the relationships between trait emotional intelligence (EI) and fMRI activation patterns in individual subjects during the multimodal perception of nonverbal emotional signals from voice and face. Trait EI was linked to hemodynamic responses in the right pSTS, an area which also exhibits a distinct sensitivity to human voices and faces. Within all other regions known to subserve the perceptual audiovisual integration of human social signals (i.e., amygdala, fusiform gyrus, thalamus), no such linked responses were observed. This functional difference in the network for the audiovisual perception of human social signals indicates a specific contribution of the pSTS as a possible interface between the perception of social information and social cognition. Hum Brain Mapp, 2010. © 2009 Wiley‐Liss, Inc.