bluuebunny/crossref_metadata_2025_split huggingface dataset:
XXI.—A Study of the Incidence, Distribution and Characteristics of Blood Spots and Miniature Eggs
Authors: Sharma Ganpati Parshad 
Published: June 2012

There are two commonly met with types of defective eggs laid by the domestic hen that result in considerable financial loss to the poultry farmer, and are frequent enough in their occurrence to affect perceptibly the potential food supply derived from the poultry industry.The first of these results from the inclusion of blood or meat spots in eggs, and the second is the production of eggs so small as to make the majority of them unsaleable—the so-called “Miniature” eggs.The presence of blood on the yolk of an egg was recorded by Aristotle as early as 300 B.C., and he attributed it to premature ovulation. Later, about A.D. 1600, Fabricius (Adelmann, 1942), during a demonstration of “sanguineous” eggs to his anatomy class, described a livercoloured body included in an egg. The occurrence of blood spots in eggs led both these authors to propound the theory that the yolk was directly formed from blood.
XVIII.—New Lamellibranchs from the Gutterford Burn Flagstones (Gala-Tarannon) of the Pentland Hills, near Edinburgh
Authors: Lamont Archie 
Published: June 2012

SynopsisAlong with a note on Chonetes aff. edmundsi Williams and other associated fossils, nine new Lamellibranch species are described from what appear to be the Gutterford Burn Flagstones (Monoclimacis crenulata Zone), repeated by folding or thrusting, northwest of the North Esk reservoir and in the lower part of the Deerhope glacial-overflow valley, in the Pentland Hills. The localities occur respectively in the Midlothian and Peeblesshire parts of the Silurian sequence. The fauna represents an Upper Gala-Tarannon horizon, and is intermediate in age between Upper Llandovery and Lower Wenlock.
XXIV.—Egg Attachment inCrangon vulgarisand other Caridea
Authors: Yonge C. M. 
Published: June 2012

SynopsisIn the Caridea, unlike the allied Euphausiacea and Penæidea, developing eggs are attached by means of a “cement” to specialized non-pinnate ovigerous setæ on pleopods 1–4; inCrangonalso to periopods 4 and 5. The presence of these eggs does not prevent flexure of the abdomen and execution of backward escape movements. The form of the abdomen differs in relation to habit, and this, together with the disposition of the ovigerous setæ, which varies greatly in different genera and in different pleopods of the same species, conditions the arrangement of the egg-mass. Ovigerous setæ increase both in numbers and in length with age; so do the number of eggs which have to be attached. There is concentration in the pleopods of “cement” glands identical with the tegumental glands which secrete the epicuticle which the “cement” resembles in all respects. Ducts run into the ovigerous setæ but it remains obscure where the “cement” emerges; possibly it dissolves its way through the integument of the setæ to emerge at many places simultaneously. Attachment of eggs in the Caridea may be associated with the many different habits exhibited; the developing eggs are protected and hatch out in the often restricted environment of the parent.
VI.—An Investigation of the Hepatotoxic Effects in the Fowl of Ragwort (Senecio jacobæa Linn.), with special reference to the Induction of Liver Tumours with Seneciphylline
Authors: Campbell J. G. 
Published: June 2012

SynopsisThe alkaloids of Ragwort (Senecio jacobæa Linn.) are known to be hepatotoxic to farm animals and man. Survivors invariably show permanent impairment of the liver, manifested by cirrhosis and its sequelæ. Senecio infusions may be consumed in small amounts in Britain as a herbal remedy, and in South Africa the Bantu frequently incorporate them in native medicines. It has been shown that these tribes have a high incidence of cirrhosis and primary liver cancer, and there is good evidence that their deficient diet may play an important part in sensitizing the liver to toxins. In the present study, the ragwort alkaloid seneciphylline has been administered by injection to fowls maintained on both adequate and deficient diets, and further fowls received the dried plant in their food. A significant proportion of these birds subsequently developed primary liver tumours. Although there was a higher mortality rate in both treated and controls fed the deficient diet, there was no evidence of a greater tendency to develop liver tumours compared with the birds on the balanced diet.It is also suggested that the condition known as “cavernous angioma” of the liver of cattle and sheep in Britain may be due to ingestion of ragwort in sub-lethal amounts.
Assessing the Effect of Information on the Reservation Price for Champagne: What are Consumers Actually Paying for?
Authors: Combris Pierre , Lange Christine , Issanchou Sylvie 
Published: June 2012

AbstractTwo series of Vickrey auctions have been performed to assess the effect of packaging information (bottle and label) on the reservation prices of ordinary consumers for five brut non-vintage Champagnes. As in other studies on wine tasting, packaging information is found to explain much more of the variation in willingness to pay than sensory information. Participants are unable, or unwilling, to put different values on the Champagnes after blind tasting, but significant differences in reservation prices appear when labels are disclosed. Detailed analysis of choices reveals a large heterogeneity in individual behaviors and valuations of the Champagnes included in this study. (JEL Classification: C91, D12)
Growers vs. Merchants Bargaining on the Price of Champagne Grapes and The Role of Contracts when Bargaining is Unbalanced
Authors: Chambolle Claire , Saulpic Olivier 
Published: June 2012

AbstractThe contract between growers and merchants for the exchange of grapes on the Champagne market is a long-term agreement based on quantities. Commitments on quantities are made for several years and negotiated individually between growers and merchants. Each year, prices are negotiated at the interprofessional level, the interprofessional committee including members of the growers union, members of the merchants union and a government commissioner. It turns out that industrial organization theory, and more precise mechanisms outlined by incomplete contract theory are relevant to the analysis of such contracts in which prices and quantities are negotiated sequentially and by different groups of actors. We show that imposed pricing by the interprofessional organization can, in some cases, balance the bargaining power between growers and merchants and thus increase social welfare. At a time when the European Common Organization of Wine Markets casts doubt on interprofessional organizations, this result tends to justify their positive role. (JEL classifi cation: L42, L50)
Price Formation in the California Winegrape Economy
Authors: Heien Dale 
Published: June 2012

AbstractThis paper presents a theory of price determination for winegrapes in California. As the California wine economy developed, winegrape contracts took on a role as one of the centerpieces of this transformation. The theory is presented and it is shown how two important factors, weather and fi nancial uncertainty, served to shape the contracts. Hence, long term planting contracts for new vineyards, specifying the price, helped ameliorate the uncertainty to growers. Similarly, shorter contracts played a similar role for established vintners. The model deals with two types of growers: those with contracts made well before the year in question and those who will sign a contract in the Spring of the year of harvest. This paper hopes to illuminate these elements and their interaction. The model is then empirically estimated and tested. (JEL classifi cation: K12, Q11)
On Wine Bullshit: Some New Software?
Authors: Quandt Richard E. 
Published: June 2012

The inspiration for the exegesis that follows comes directly from Harry G. Frankfurt, distinguished emeritus professor of philosophy at Princeton University, who recently published an enormously successful essay on the subject of bullshit (Frankfurt, 2005). In the author's view,“One of the most salient features of our culture is that there is so much bullshit. Everyone knows this. Each of us contributes his share. But we tend to take the situation for granted. Most people are rather confident of their ability to recognize bullshit and to avoid being taken in by it. So the phenomenon has not aroused much deliberate concern. We have no clear understanding of what bullshit is, why there is so much of it, or what functions it serves.” (Frankfurt, 2005, p. 1)A fine philosophical insight into bullshit is provided by Bernie Laplante, played by Dustin Hoffman in the movie “Hero.”
The Wines of West Africa: History, Technology and Tasting Notes
Authors: Noll Roger G. 
Published: June 2012

AbstractFor centuries West Africans have made wines from palm sap, and hard liquor (“gin”) from palm wine. This essay describes the role of palm wine in West African society, attempts to regulate its production and consumption since colonial times, the basics of the production process, and the appearance, bouquet and flavor of unpasteurized palm wine as it ages through its useful life of a day or two. (JEL Classification: L66, L51,118)
Guest Editor's Introduction to Symposium
Authors: McCluskey Jill J. 
Published: June 2012

The articles in this symposium analyze the economics of evolving international wine markets, including issues associated with taxes, measures of quality, reputation, consumer preferences, globalization, and emerging markets in China. This special symposium consists of peer-reviewed papers presented at the “Competitive Forces Affecting the Wine and Winegrape Industries: An International Conference on World Wine Markets,” sponsored by the Washington State University Impact Center, the Center for Wine Economics and Business of the Robert Mondavi Institute for Wine and Food Sciences and the Giannini Foundation of Agricultural Economics, University of California, in Davis, California, August 8–10, 2007, and the American Association of Wine Economists in Portland, Oregon, August 14–16, 2008.The first paper, by Rachael Goodhue, Jeffrey LaFrance and Leo Simon, provides a theoretical analysis of the impact of taxes on the quantity and quality produced by a competitive firm of goods like wine for which market value. They consider the effects of various tax systems on wine quality and quantity distortions.
Economic Feasibility of Wine Grape Production in the Arid US: A Northwest Nevada Example
Authors: Curtis Kynda R. , Bishop Carol D. , Harris Thomas R. 
Published: June 2012

AbstractAs competition for water resources increases and water availability in arid regions declines, agricultural producers are encouraged to adopt water-conserving strategies. This study examines the economic feasibility of implementing wine grapes in northwest Nevada as a diversification and water conservation strategy. Results show profit potential when vitis interspecific wine grape varieties are produced in the region. Net returns based upon point estimates from two separate analyses show per-acre net returns at $1,065 and $3,022, respectively. However, the large variation in potential net returns shown in the risk analysis, combined with a high capital investment cost of more than $17,000 per acre, may preclude producers from exercising their option to adopt wine grape production. Also, including wine grapes in the on-farm crop portfolio will affect its risk and return characteristics, likely impacting producer preferred level of wine grape adoption. (JEL Classification: Q11, Q15, Q25, Q54)
Predicting the Quality and Prices of Bordeaux Wine
Authors: Ashenfelter Orley 
Published: June 2012

AbstractBordeaux wines have been made in much the same way for centuries. This article shows that the variability in the quality and prices of Bordeaux vintages is predicted by the weather that created the grapes. The price equation provides a measure of the real rate of return to holding wines (about 2–3% per annum) and implies far greater variability in the early or ‘en primeur’ wine prices than is observed. The analysis provides a useful basis for assessing market inefficiency, the effect of climate change on the wine industry and the role of expert opinion in determining wine prices. (JEL Classification: D43, Q11)
Do Tasting Notes Add Value? Evidence from Napa Wines
Authors: Ramirez Carlos D. 
Published: June 2012

AbstractThis paper evaluates whether tasting notes—the brief testimony that describes the sensory properties of wines—add value. The analysis is based on a sample of over 2700 recent-vintage cabernet sauvignon wines evaluated byWine Spectator. I estimate a dynamic wine price model to evaluate the marketing effect of the note, controlling for quality measures as well as other wine characteristics. The results indicate that the length of the tasting note exerts a strong positive influence on the wine's price, even after controlling for quality. A 10 percent increase in the number of characters in the tasting note (about 23 additional characters) contributes about two to four dollars to the price of the wine. Further analysis reveals that the value of the tasting note does not come from the “analytical” words contained in the note but rather, from the more subjective component of it. (JEL Classification: L66, L11, C23)
Too Much of a Good Thing? Causes and Consequences of Increases in Sugar Content of California Wine Grapes
Authors: Alston Julian M. , Fuller Kate B. , Lapsley James T. , Soleas George 
Published: June 2012

AbstractThe sugar content of California wine grapes has increased significantly over the past 10–20 years, and this implies a corresponding increase in the alcohol content of wine made with those grapes. In this paper we develop a simple model of winegrape production and quality, including sugar content and other characteristics as choice variables along with yield. Using this model we derive hypotheses about alternative theoretical explanations for the phenomenon of rising sugar content of grapes, including effects of changes in climate and producer responses to changes in consumer demand. We analyze detailed data on changes in the sugar content of California wine grapes at crush to obtain insight into the relative importance of the different influences. We buttress this analysis of sugar content of wine grapes with data on the alcohol content of wine. (JEL Classification: Q54, Q19, D12, D22)
From Monasteries to Multinationals (and Back): A Historical Review of the Beer Economy
Authors: Poelmans Eline , Swinnen Johan F.M. 
Published: June 2012

AbstractThis article reviews beer production, consumption and the industrial organization of breweries throughout history. Monasteries were the centers of the beer economy in the early Middle Ages. Innovation and increased demand later induced the growth of commercial breweries. Globalization and scientific discoveries transformed the beer industry and increased competition from the 16th through the 19th century. The 20th century was characterized by dramatic (domestic and international) consolidation, major shifts in consumption patterns, and the re-emergence of small breweries. (JEL Classification: N30, N40, L23, L66)
Massive layer of pure anorthosite on the Moon
Authors: Yamamoto S. , Nakamura R. , Matsunaga T. , Ogawa Y. , Ishihara Y. , Morota T. , Hirata N. , Ohtake M. , Hiroi T. , Yokota Y. , Haruyama J. 
Published: June 2012

We present a new global survey of the purest anorthosite (PAN) rock using the Spectral Profiler onboard Kaguya. We found that PAN rocks are widely distributed over the Moon, including the Feldspathic Highland Terrain and the south and north polar regions. All PAN sites are associated with huge impact structures with diameters larger than 100 km. Based on the global distributions of PAN and olivine‐rich sites, we propose the existence of a massive PAN layer with a thickness of ∼50 km below an uppermost mafic‐rich mixed layer with a thickness of ∼10 km. Below the PAN layer, a lower crustal layer with olivine‐rich materials may be present on the nearside, but not on the far side of the Moon. The existence of a PAN layer with a thickness of ∼50 km suggests an Al2O3 abundance of 33 to 34 wt.% in the lunar crust, which is higher than previous estimates of <32 wt.%. Our data indicate the massive production event of PAN during the early stage of the formation of the Moon, supporting the lunar magma ocean scenario.
Evidence of Local Adaptation in Westslope Cutthroat Trout
Authors: Drinan Daniel P. , Zale Alexander V. , Webb Molly A. H. , Taper Mark L. , Shepard Bradley B. , Kalinowski Steven T. 
Published: June 2012

AbstractAn understanding of the process of local adaptation would allow managers to better protect and conserve species. Many salmonids are in need of such efforts, and because they often persist in differing, isolated environments, they are useful organisms for studying local adaptation. In addition, the temperature sensitivity of salmonids provides a likely target for natural selection. We studied thermal adaptation in four wild populations and one hatchery stock of westslope cutthroat trout Oncorhynchus clarkii lewisi. The mean summer temperatures of source streams ranged from 6.7°C to 11.2°C. Embryos were collected from the wild, and embryonic development, embryonic survival, and juvenile growth were determined. A significant relationship between median embryonic survival and source stream temperature was detected. Based on a rank test, populations from colder streams had a greater decline in median embryonic survival at warm temperatures than populations from warmer streams. Embryonic development and juvenile growth did not appear to be influenced by source. These findings suggest that populations are thermally adapted to their source streams and this should be considered by managers. However, further study is necessary to sort out the potential confounding factors, whether genetic or epigenetic.
Lineage-based identification of cellular states and expression programs
Authors: Hashimoto Tatsunori , Jaakkola Tommi , Sherwood Richard , Mazzoni Esteban O. , Wichterle Hynek , Gifford David 
Published: June 2012

Abstract
Summary: We present a method, LineageProgram, that uses the developmental lineage relationship of observed gene expression measurements to improve the learning of developmentally relevant cellular states and expression programs. We find that incorporating lineage information allows us to significantly improve both the predictive power and interpretability of expression programs that are derived from expression measurements from in vitro differentiation experiments. The lineage tree of a differentiation experiment is a tree graph whose nodes describe all of the unique expression states in the input expression measurements, and edges describe the experimental perturbations applied to cells. Our method, LineageProgram, is based on a log-linear model with parameters that reflect changes along the lineage tree. Regularization with L1 that based methods controls the parameters in three distinct ways: the number of genes change between two cellular states, the number of unique cellular states, and the number of underlying factors responsible for changes in cell state. The model is estimated with proximal operators to quickly discover a small number of key cell states and gene sets. Comparisons with existing factorization, techniques, such as singular value decomposition and non-negative matrix factorization show that our method provides higher predictive power in held, out tests while inducing sparse and biologically relevant gene sets.
Contact: gifford@mit.edu
Fast alignment of fragmentation trees
Authors: Hufsky Franziska , Dührkop Kai , Rasche Florian , Chimani Markus , Böcker Sebastian 
Published: June 2012

Abstract
Motivation: Mass spectrometry allows sensitive, automated and high-throughput analysis of small molecules such as metabolites. One major bottleneck in metabolomics is the identification of ‘unknown’ small molecules not in any database. Recently, fragmentation tree alignments have been introduced for the automated comparison of the fragmentation patterns of small molecules. Fragmentation pattern similarities are strongly correlated with the chemical similarity of the molecules, and allow us to cluster compounds based solely on their fragmentation patterns.
Results: Aligning fragmentation trees is computationally hard. Nevertheless, we present three exact algorithms for the problem: a dynamic programming (DP) algorithm, a sparse variant of the DP, and an Integer Linear Program (ILP). Evaluation of our methods on three different datasets showed that thousands of alignments can be computed in a matter of minutes using DP, even for ‘challenging’ instances. Running times of the sparse DP were an order of magnitude better than for the classical DP. The ILP was clearly outperformed by both DP approaches. We also found that for both DP algorithms, computing the 1% slowest alignments required as much time as computing the 99% fastest.
Contact: sebastian.boecker@uni-jena.de
Dissect: detection and characterization of novel structural alterations in transcribed sequences
Authors: Yorukoglu Deniz , Hach Faraz , Swanson Lucas , Collins Colin C. , Birol Inanc , Sahinalp S. Cenk 
Published: June 2012

Abstract
Motivation: Computational identification of genomic structural variants via high-throughput sequencing is an important problem for which a number of highly sophisticated solutions have been recently developed. With the advent of high-throughput transcriptome sequencing (RNA-Seq), the problem of identifying structural alterations in the transcriptome is now attracting significant attention.
In this article, we introduce two novel algorithmic formulations for identifying transcriptomic structural variants through aligning transcripts to the reference genome under the consideration of such variation. The first formulation is based on a nucleotide-level alignment model; a second, potentially faster formulation is based on chaining fragments shared between each transcript and the reference genome. Based on these formulations, we introduce a novel transcriptome-to-genome alignment tool, Dissect (DIScovery of Structural Alteration Event Containing Transcripts), which can identify and characterize transcriptomic events such as duplications, inversions, rearrangements and fusions. Dissect is suitable for whole transcriptome structural variation discovery problems involving sufficiently long reads or accurately assembled contigs.
Results: We tested Dissect on simulated transcripts altered via structural events, as well as assembled RNA-Seq contigs from human prostate cancer cell line C4-2. Our results indicate that Dissect has high sensitivity and specificity in identifying structural alteration events in simulated transcripts as well as uncovering novel structural alterations in cancer transcriptomes.
Availability: Dissect is available for public use at: http://dissect-trans.sourceforge.net
Contact: denizy@mit.edu; fhach@cs.sfu.ca; cenk@cs.sfu.ca