bluuebunny/crossref_metadata_2025_split huggingface dataset:
Immunotherapy in the Management of Sinonasal Mucosal Melanoma: A Systematic Review
Authors: Tang Anthony , Taori Suchet , Dang Sophia , Gardner Paul A. , Zenonos Georgios A. , Davar Diwakar , Kuan Edward C. , Snyderman Carl H. , Wang Eric W. , Choby Garret 
Published: April 2024

AbstractObjectiveThe aim of this work is to comprehensively review and synthesize the literature related to sinonasal mucosal melanoma (SNMM) treatment with immunotherapy, including potentially targetable genetic mutations, survival outcomes, and adverse events.Data SourcesEmbase, Cochrane, Scopus, and Web of Science.Review MethodsThe study protocol was designed according to Preferred Reporting Items for Systematic Reviews and Meta‐analysis statement. Databases were searched from inception through May 23, 2023.ResultsA total of 42 studies met inclusion criteria. Twenty‐four of the included studies reported genetic mutations for a combined 787 patients with SNMM. 8.1% (95% confidence interval, CI: 7.6‐8.6), 18.9% (95% CI: 18.1‐19.8), and 8.5% (95% CI: 8.1‐9.0) of reported patients were positive for BRAF, NRAS, and KIT mutations, respectively. The presence of brisk tumor‐infiltrating lymphocytes was associated with improved recurrence‐free survival and overall survival (OS). Six studies reported a combined 5‐year OS after adjuvant immunotherapy treatment of 42.6% (95% CI: 39.4‐45.8). Thirteen studies encompassing 117 patients reported adjuvant or salvage immune checkpoint inhibitor (ICI) immunotherapy response rates: 40.2% (95% CI: 36.8‐43.6) had a positive response (tumor volume reduction or resolution). Eleven studies reported direct comparisons between SNMM patients treated with or without immunotherapy; the majority (7/11) reported survival benefit for their entire cohort or select subgroups of SNMM patients. With the transition to modern ICIs, there is a stronger trend toward survival improvement with adjuvant ICI. Tumors with Ki67 <40% may respond better to ICI's.ConclusionICI therapy can be an effective in select SNMM patients, especially those with advanced/metastatic disease.
Tunable Release of Ions from Graphene Oxide Laminates for Sustained Antibacterial Activity in a Biomimetic Environment
Authors: Suran Swathi , Kamyar Negin , Huang Kun , Foroutan Farzad , Balakrishna Pillai Premlal , Liu Xuzhao , Vaughan John , Wilson Darren , Day Philip J. , Nair Rahul R. 
Published: April 2024

AbstractSilver has long been recognized for its potent antimicrobial properties, but achieving a slow and longer‐term delivery of silver ions presents significant challenges. Previous efforts to control silver ion dosages have struggled to sustain release for extended periods in biomimetic environments, especially in the presence of complex proteins. This challenge is underscored by the absence of technology for sustaining antimicrobial activity, especially in the context of orthopedic implants where long‐term efficacy, extending beyond 7 days, is essential. In this study, the tunable, slow, and longer‐term release of silver ions from the two‐dimensional (2D) nanocapillaries of graphene oxide (GO) laminates incorporated with silver ions (Ag‐GO) for antimicrobial applications are successfully demonstrated. To closely mimic a physiologically relevant serum‐based environment, a novel in vitro study model using 100% fetal bovine serum (FBS) is introduced as the test medium for microbiology, biocompatibility, and bioactivity studies. To emulate fluid circulation in a physiological environment, the in vitro studies are challenged with serum exchange protocols on different days. The findings show that the Ag‐GO coating can sustainably release silver ions at a minimum dosage of 10 µg cm−2 day−1, providing an effective and sustained antimicrobial barrier for over ten days.
Toward Quantitative Electrodeposition via In Situ Liquid Phase Transmission Electron Microscopy: Studying Electroplated Zinc Using Basic Image Processing and 4D STEM
Authors: Park Junbeom , Dutta Sarmila , Sun Hongyu , Jo Janghyun , Karanth Pranav , Weber Dieter , Tavabi Amir H. , Durmus Yasin Emre , Dzieciol Krzysztof , Jodat Eva , Karl André , Kungl Hans , Pivak Yevheniy , Garza H. Hugo Pérez , George Chandramohan , Mayer Joachim , Dunin‐Borkowski Rafal E. , Basak Shibabrata , Eichel Rüdiger‐A 
Published: April 2024

AbstractHigh energy density electrochemical systems such as metal batteries suffer from uncontrollable dendrite growth on cycling, which can severely compromise battery safety and longevity. This originates from the thermodynamic preference of metal nucleation on electrode surfaces, where obtaining the crucial information on metal deposits in terms of crystal orientation, plated volume, and growth rate is very challenging. In situ liquid phase transmission electron microscopy (LPTEM) is a promising technique to visualize and understand electrodeposition processes, however a detailed quantification of which presents significant difficulties. Here by performing Zn electroplating and analyzing the data via basic image processing, this work not only sheds new light on the dendrite growth mechanism but also demonstrates a workflow showcasing how dendritic deposition can be visualized with volumetric and growth rate information. These results along with additionally corroborated 4D STEM analysis take steps to access information on the crystallographic orientation of the grown Zn nucleates and toward live quantification of in situ electrodeposition processes.
Endovascular Thrombectomy for Large Ischemic Strokes with ASPECTS 0–2: a Meta-analysis of Randomized Controlled Trials
Authors: Winkelmeier Laurens , Maros Máté , Flottmann Fabian , Heitkamp Christian , Schön Gerhard , Thomalla Götz , Fiehler Jens , Hanning Uta 
Published: April 2024

Abstract
Purpose
Randomized controlled trials (RCTs) demonstrated a treatment effect of endovascular thrombectomy in acute ischemic stroke with large infarct, commonly defined as an Alberta Stroke Program Early CT Score (ASPECTS) of 3–5. However, data on endovascular thrombectomy in patients with very low ASPECTS of 0–2 remain scarce.

Methods
We conducted a systematic review and meta-analysis of RCTs comparing endovascular thrombectomy versus medical treatment alone in acute ischemic anterior circulation stroke with very large infarct, defined as ASPECTS of 0–2. The primary outcome was the shift toward better functional outcomes on the 90-day modified Rankin Scale (mRS). Random effects meta-analysis was performed using the generic inverse variance method.

Results
Literature research identified four RCTs which evaluated the treatment effect of endovascular thrombectomy for large infarcts and provided a subgroup analysis of the mRS shift in patients with ASPECTS of 0–2. The pooled analysis showed a significant shift toward better 90-day mRS scores in favor of endovascular thrombectomy (pooled odds ratio, 1.62, 95% confidence interval, 1.29–2.04, P < 0.001).

Conclusion
This meta-analysis suggests a treatment effect of endovascular thrombectomy in specific patients with very low ASPECTS of 0–2, challenging the use of ASPECTS for treatment selection in acute ischemic stroke due to large vessel occlusion. An individual patient meta-analysis of RCTs would strengthen evidence in the treatment of patients with ASPECTS of 0–2.

Graphic abstract
Quasiconformal deformation of the chordal Loewner driving function and first variation of the Loewner energy
Authors: Sung Jinwoo , Wang Yilin 
Published: April 2024

AbstractWe derive the variational formula of the Loewner driving function of a simple chord under infinitesimal quasiconformal deformations with Beltrami coefficients supported away from the chord. As an application, we obtain the first variation of the Loewner energy of a Jordan curve, defined as the Dirichlet energy of its driving function. This result gives another explanation of the identity between the Loewner energy and the universal Liouville action introduced by Takhtajan and Teo, which has the same variational formula. We also deduce the variation of the total mass of $$\hbox {SLE}_{8/3}$$

SLE

8
/
3

loops touching the Jordan curve under quasiconformal deformations.
Quantitative analysis of body colouration in Sebastes rockfishes
Authors: Deville Diego , Kawai Kentaro , Umino Tetsuya 
Published: April 2024

AbstractBody colouration, a trait under strong selection, is influenced by the visual background of the environment. The stable influence of depth on visual background dynamics is due to light attenuation along the water column. Depth is also a key factor driving diversification in Sebastes rockfishes, influencing variations in several biological traits. Comparisons between closely related species suggest that brightly coloured species (red, orange, or yellow) tend to inhabit deeper waters and have slower growth rates compared to their shallow-water counterparts with dominance of dark colours (black, brown, or grey). Here, we used 377 photos from 100 Sebastes species, along with recently developed methods of colour quantification and phylogenetic comparative analyses, to assess this trend. Our analyses confirmed the separation of body colouration regarding depth, which was accompanied by differences in growth rates and morphological traits. This indicated that variations in body colourations are included in the ongoing correlational selection process dictated by depth. Analyses of closely related species indicated that depth is an initial driver of colour differentiation and that colour differences do not progressively increase with genetic divergences. We hypothesized that the bright-coloured rockfishes are found in deeper waters because in shallow environments they are more vulnerable to the potential negative effects of UV radiation and higher predation risk, while their predation successes are lessened, in comparison to dark-coloured rockfishes. Overall, this study emphasizes the intricate relationship between genetics, environment, adaptation, and the striking diversity of body colourations observed in Sebastes rockfishes.
Off-Axis Co-Optical Path Large-Range Line Scanning Chromatic Confocal Sensor
Authors: Liao Meizhong , Yang Yuqi , Lu Xiaolian , Li Haiqi , Zhang Jun , Wang Jinfeng , Chen Zhe 
Published: April 2024

AbstractThis article proposes a line scanning chromatic confocal sensor to solve the problem of limited chromatic confocal measurement due to the small measurement range and low measurement efficiency in the industrial inspection process. To obtain an extensive dispersion range, the advantages of a simple single-axis structure are combined with the advantages of a large luminous flux of a biaxial structure. Considering large-scale measurement, our sensor uses off-axis rays to limit the illumination path and imaging path to the same optical path structure. At the same time, the field of view is expanded, and a symmetrical structure is adopted to provide a compact optical path and improve space utilization. The simulation and physical system test results shows that the sensor scanning line length is 12.5 mm, and the axial measurement range in the 450 nm to 750 nm band is better than 20 mm. The axial resolution of the detector is ±1 µm combined with the subpixel centroid extraction data processing method, and the maximum allowable tilt angle for specular reflection samples is ±7°. The thicknesses of transparent standard flat glass and the wet collagen membrane are measured. The maximum average error is 1.3 µm, and the relative error is within 0.7%. The constructed sensor is of great significance for rapidly measuring the three-dimensional profile, flatness, and thickness in the fields of transparent biological samples, optics, micromechanics, and semiconductors.
‘Girls do this, guys do that’: how first-in-family students negotiate working-class gendered subjectivities during a time of social change
Authors: McDonald Sarah , Stahl Garth 
Published: April 2024

AbstractDespite efforts to foster a more equitable gender representation, Australia's higher education sector and workforce continue to be highly segregated. This article focusses on the gendered experiences of first-in-family (FIF) students—many who are from low-socioeconomic communities—transitioning to Australian universities. In terms of the gendered nature of widening participation, we know students who are FIF will often study disciplines which align with traditional gender norms. Drawing on the First-in-Family Project (n = 48), we present the analysis of our findings in two parts. First, we provide an overview of the cohort where we analyse the gendering of degree choice of FIF students. Second, underpinned by theoretical work focussed on student gendered and classed subjectivities, we address how FIF young people negotiated classed and gendered norms during the transition to university. Our data suggest that young people engage in ‘gender work’ and ‘class work’ which informs their identities and how they make choices about their futures. Based on our research, we argue that to achieve social justice there is a need for a renewed attention to gender within the widening participation agenda.
Comparison of microwave assisted foam drying processes to improve the physicochemical properties and to reduce GHG values of the melon powder processes
Authors: TAŞOVA Muhammed , DURSUN Samet Kaya 
Published: April 2024

AbstractIn this study, in the process of valorizing melon biomass into food powder at 360, 540, 720 and.900 W power values; Drying rate, moisture rate, effective moisture diffusion, SMER-SEC energy consumption and greenhouse gas emission (GHG) values of production processes were investigated. It was determined that the average drying rates of the samples varied between 0.2393–0.9376 g moisture/g dry matter.minute. According to microwave power values, the effective moisture diffusion values of the products were found to vary between 5.47 × 10–7-2.27 × 10–6 m2/s. It was determined that the average SMER values of the drying processes varied between 0.024–0.047 kg/kWh and SEC values varied between 21.12–40.93 kWh/kg. According to the drying processes, NOX, SO2 and CO2 values were calculated to vary between 0.210–1.106, 0.00–2.919 and 49.50–200.168 g, respectively. It was found that the most suitable microwave power in terms of drying kinetics, energy consumption and greenhouse gas values was 900 W.
Beta-lactam antibiotics administration among adult inpatients with a beta-lactam allergy label: incidence, predictors, and outcomes
Authors: Epstein-Rigbi Naama , Ziv Sharon , Bulanenkova Marina , Bouganim Ruth , Tal-Jasper Ruthy , Marchaim Dror 
Published: April 2024

Abstract

Background:
A beta-lactam antibiotics (BLA) allergy label is common, resulting in disadvantageous outcomes due to the usage of second-line antimicrobial agents. Noncontrolled case-series analyses report low rates of hypersensitivity reactions, following intentional/non-intentional BLA challenges among labeled inpatients. The study aims were to explore predictors and outcomes associated with hypersensitivity reactions following BLA challenge among BLA-allergic labeled inpatients.

Methods:
Retrospective cohort study (2019–2020) of adult (≥18 years) inpatients (Shamir Medical Center, Israel), labeled as allergic to ≥1 BLA, who received ≥1 dose/s of BLA during their stay. Independent predictors to develop allergic reactions and the independent associations of allergic reactions with clinical outcomes were queried by logistic and Cox regressions.

Results:
Of 9,670 inpatients (14,088 hospitalizations), 3,570 (37%) were labeled as allergic to ≥1 BLA. Of those, 1,171 (33%) patients received ≥1 BLA. The majority were women (67%), and the mean age was 69.3 ± 19.4 years. Only 30 patients (2.6%) developed a reaction, all mild. Independent predictors to develop an allergic reaction were documented reactions in the past, atopic background, antihistamines administration prior to the BLA challenge, and high risk for cross-reactivity, based on the BLA side chains, between the labeled and the challenged agents. Reaction upon the BLA challenge was not independently associated with any worse outcome.

Conclusions:
Despite the commonality of allergy labeling, and the commonality of BLA administration to labeled inpatients, hypersensitivity reactions were mild and rare. Interventional stewardship strategies for active BLA de-labeling among low-risk patients should be promoted, to improve patients’ and institutional health and fiscal outcomes.
Getting the message right: what are the impacts of counter-serious and organised crime awareness-raising strategies?
Authors: Cheeseman Nic , Peiffer Caryn 
Published: April 2024

Abstract
Counter-serious and organised crime (SOC) strategies often include an awareness-raising element. Such messaging aims to build support for counter-SOC efforts, and intolerance for organised criminal activity. However, a growing body of research suggests that raising awareness to ‘social bads’ like SOC may risk backfiring by encouraging pessimistic attitudes about whether they can be controlled and could even nudge people to agree with populist narratives which argue that political outsiders represent the only hope for tackling systemic problems. A nationally representative survey experiment in Albania was conducted to test, for the first time, the impact of messages about SOC. Typical of counter-SOC messaging in practice, the first message emphasised the harms SOC causes. The second was more positive, highlighting high levels of social disapproval of SOC, a theme that social norms research suggests may be effective. We find that the first message backfires by reducing confidence in law enforcement and encouraging support for populist ideas. The second message is unexpectedly found to also encourage support for a populist sentiment, while having no positive impact on attitudes about law enforcement. This suggests that even positive messaging about ‘social bads’ can risk triggering unwanted responses.
Hallsworth's manifesto through a cultural theory lens
Authors: John Peter 
Published: April 2024

Abstract
Behavioural public policy (BPP) operates within one of four cultural models of public management, an illustration of an influential scheme set out by Christopher Hood. Even though BPP can be fatalist, individualist or egalitarian, so far it has been hierarchicalist. Hallsworth's manifesto is largely an expression of this hierarchicalist form of public management, with all its limitations and contradictions. As the manifesto pays relatively little attention to decentralist and egalitarian approaches, it misses a radical opportunity. Future work on BPP could incorporate entrepreneurial and egalitarian possibilities while recognising the difficulties of moving away from hierarchalism completely. Even though Hood cautions against a ‘public management for all seasons’, it remains a plausible path for the next generation of researchers and practitioners of BPP.
Emergent behaviours of a non-abelian quantum synchronisation model over the unitary group
Authors: Kim Dohyun , Kim Jeongho 
Published: April 2024

Abstract
We introduce a new non-abelian quantum synchronisation model over the unitary group, represented as a gradient flow, where state matrices asymptotically converge to a common one up to phase translation. We provide a sufficient framework leading to quantum synchronisation based on Riccati-type differential inequalities. In addition, uniform time-delayed interaction is considered for modelling realistic communication, and we demonstrate that quantum synchronisation is persistent when a small time delay is allowed. Finally, numerical simulation is performed to visualise qualitative behaviours and support theoretical results.
Dopamine signaling enriched striatal gene set predicts striatal dopamine synthesis and physiological activity in vivo
Authors: Sportelli Leonardo , Eisenberg Daniel P. , Passiatore Roberta , D’Ambrosio Enrico , Antonucci Linda A. , Bettina Jasmine S. , Chen Qiang , Goldman Aaron L. , Gregory Michael D. , Griffiths Kira , Hyde Thomas M. , Kleinman Joel E. , Pardiñas Antonio F. , Parihar Madhur , Popolizio Teresa , Rampino Antonio , Shin Joo Heon , Veronese Mattia , Ulrich William S. , Zink Caroline F. , Bertolino Alessandro , Howes Oliver D. , Berman Karen F. , Weinberger Daniel R. , Pergola Giulio 
Published: April 2024

AbstractThe polygenic architecture of schizophrenia implicates several molecular pathways involved in synaptic function. However, it is unclear how polygenic risk funnels through these pathways to translate into syndromic illness. Using tensor decomposition, we analyze gene co-expression in the caudate nucleus, hippocampus, and dorsolateral prefrontal cortex of post-mortem brain samples from 358 individuals. We identify a set of genes predominantly expressed in the caudate nucleus and associated with both clinical state and genetic risk for schizophrenia that shows dopaminergic selectivity. A higher polygenic risk score for schizophrenia parsed by this set of genes predicts greater dopamine synthesis in the striatum and greater striatal activation during reward anticipation. These results translate dopamine-linked genetic risk variation into in vivo neurochemical and hemodynamic phenotypes in the striatum that have long been implicated in the pathophysiology of schizophrenia.
Oxyresveratrol-β-cyclodextrin mitigates streptozotocin-induced Alzheimer's model cognitive impairment, histone deacetylase activity in rats: in silico & in vivo studies
Authors: Agarwal Tushar , Manandhar Suman , B Harish Kumar , Famurewa Ademola C. , Gurram Prasada Chowdari , Suggala Ramya Shri , Sankhe Runali , Mudgal Jayesh , Pai K. Sreedhara Ranganath 
Published: April 2024

AbstractAlzheimer’s disease (AD) is associated with cognitive deficits and epigenetic deacetylation that can be modulated by natural products. The role of natural oxyresveratrol-β-cyclodextrin (ORV) on cognition and histone deacetylase activity in AD is unclear. Herein, in-silico docking and molecular dynamics simulation analysis determined that oxyresveratrol potentially targets histone deacetylase-2 (HDAC2). We therefore evaluated the in vivo ameliorative effect of ORV against cognitive deficit, cerebral and hippocampal expression of HDAC in experimental AD rats. Intracerebroventricular injection of STZ (3 mg/kg) induced experimental AD and the rats were treated with low dose (200 mg/kg), high dose (400 mg/kg) of ORV and donepezil (10 mg/kg) for 21 days. The STZ-induced AD caused cognitive and behavioural deficits demonstrated by considerable increases in acetylcholinesterase activity and escape latency compared to sham control. The levels of malondialdehyde (MDA) and HDAC activity were significantly increased in AD disease group comparison to the sham. Interestingly, the ORV reversed the cognitive-behavioural deficit and prominently reduced the MDA and HDAC levels comparable to the effect of the standard drug, donepezil. The findings suggest anti-AD role of ORV via antioxidant effect and inhibition of HDAC in the hippocampal and frontal cortical area of rats for AD.