bluuebunny/crossref_metadata_2025_split huggingface dataset:
On the effectiveness of regulatory restrictions in conducting telemedicine consultations
Authors: Makarov Vladislav Olegovich , Kovalenko Mariya Andreevna 
Published: May 2024

The article examines the introduction of an experimental legal regime in the field of telemedicine in the Russian Federation. The authors investigate the general and experimental legal regulation in the field of telemedicine services. It is noted that the main prohibition leading to the emergence of the services in the field of medicine is a ban on clarifying and directly making a diagnosis within the framework of a remote consultation without prior face-to-face appointment with the attending physician. When establishing an experimental legal regime, this prohibition was relaxed, since it is possible to seek remote consultation from another doctor working in the same medical organization and having at least 7 years of experience in the specialty. It is stated that the information services that appeared to circumvent this prohibition are actually medical. In the course of the research, general scientific methods of cognition of the surrounding reality and legal matter, as well as special legal methods, including formal legal ones, were used to achieve these goals. It is noted that when establishing, within the framework of an experimental legal regime, the possibility of prescribing treatment or correcting it by another doctor working in the same medical organization as the attending physician who conducted the preliminary face-to-face appointment of the patient, medical organizations with an extensive network of branches receive advantages for development. In such a situation, it is possible to form two levels of medical care: within the framework of the first, primary face-to-face reception is carried out by the primary link of medical workers, within the framework of the second, specialized doctors conduct remote consultation to the patient (legal representative). The establishment of a ban on diagnosis and restrictions on the prescription of treatment remotely has led to the spread of shady online counseling services. Due to the motives and goals of the patient when accessing such a service, it is essentially medical.
Interactive effects of drought and deforestation on multitrophic communities and aquatic ecosystem functions in the Neotropics—a test using tank bromeliads
Authors: Séguigne Marie , Leroy Céline , Carrias Jean-François , Corbara Bruno , Lafont Rapnouil Tristan , Céréghino Régis 
Published: May 2024

Background
Together with the intensification of dry seasons in Neotropical regions, increasing deforestation is expected to exacerbate species extinctions, something that could lead to dramatic shifts in multitrophic communities and ecosystem functions. Recent studies suggest that the effects of habitat loss are greater where precipitation has decreased. Yet, experimental studies of the pure and interactive effects of drought and deforestation at ecosystem level remain scarce.

Methods
Here, we used rainshelters and transplantation from rainforest to open areas of natural microcosms (the aquatic ecosystem and microbial-faunal food web found within the rainwater-filled leaves of tank bromeliads) to emulate drought and deforestation in a full factorial experimental design. We analysed the pure and interactive effects of our treatments on functional community structure (including microorganisms, detritivore and predatory invertebrates), and on leaf litter decomposition in tank bromeliad ecosystems.

Results
Drought or deforestation alone had a moderate impact on biomass at the various trophic level, but did not eliminate species. However, their interaction synergistically reduced the biomass of all invertebrate functional groups and bacteria. Predators were the most impacted trophic group as they were totally eliminated, while detritivore biomass was reduced by about 95%. Fungal biomass was either unaffected or boosted by our treatments. Decomposition was essentially driven by microbial activity, and did not change across treatments involving deforestation and/or drought.

Conclusions
Our results suggest that highly resistant microorganisms such as fungi (plus a few detritivores) maintain key ecosystem functions in the face of drought and habitat change. We conclude that habitat destruction compounds the problems of climate change, that the impacts of the two phenomena on food webs are mutually reinforcing, and that the stability of ecosystem functions depends on the resistance of a core group of organisms. Assuming that taking global action is more challenging than taking local-regional actions, policy-makers should be encouraged to implement environmental action plans that will halt habitat destruction, to dampen any detrimental interactive effect with the impacts of global climate change.
Statistical Quality of Life
Authors: Mesbah Mounir 
Published: March 2010

AbstractHealth Related Quality of Life (HrQoL) is a latent variable, indirectly observed through individual responses to a set of questions (items) forming the HrQoL questionnaire. The first part of the paper is about its measurement which remains a complex issue. This measurement process is done via instruments (questionnaires) which are validated through the intermediary of some fundamental models, mainly based on unidimensionality principle and some specific conditional independence properties. We explain how these measurement models are statistically validated, and how measurements they provide must be statistically analyzed in studies involving other external variables. Finally, a few important recent issues in the field are presented.
Hot zones formation during regeneration of diesel particulate filters
Authors: Chen Kai , Martirosyan Karen S. , Luss Dan 
Published: March 2010

AbstractA diesel particulate filter (DPF) is used to remove particulate matter (PM) from the diesel engine exhaust. The accumulated PM is periodically removed by combustion, which sometimes leads to excessive temperature excursions that melt the ceramic filter. This behavior cannot be explained by operation under stationary feed conditions. We propose that these temperature excursions are a dynamic effect following a rapid change in the driving mode while the DPF is being regenerated. Specifically, a rapid decrease in the exhaust temperature can lead to a counterintuitive large transient temperature rise above that which would exist under a higher stationary feed temperature. This unexpected behavior is similar to the well‐known wrong‐way behavior in packed‐bed reactors, even though the axial‐dependent flow through the filter in a DPF is rather different from the constant axial flow through a packed bed. We present simulations that provide insight about the dependence of the amplitude of this wrong‐way temperature rise on the filtration velocity, the PM loading, dimensions of the DPF, and the amplitude of the rapid temperature decrease and when it occurs after the start of the regeneration. The insight provided by these simulations will help develop operation and control protocols that circumvent or at least decrease the probability of the occurrence of the destructive melting of the DPF. © 2010 American Institute of Chemical Engineers AIChE J, 2011
The role of employers and supervisors in promoting pesticide safety behavior among florida farmworkers
Authors: Mayer Brian , Flocks Joan , Monaghan Paul 
Published: March 2010

AbstractBackgroundFarmworkers in Florida's nursery and fernery industries have an elevated risk of exposure to chemical pesticides due to the enclosed nature of their workplaces and their close contact with pesticide‐treated plant material. Farmworkers' beliefs about chemical exposures and their perception of employer's or supervisor's valuing of safety may limit the practice of workplace hygiene.MethodsThree hundred eighty‐two surveys from workers in the nursery and fernery industries in North Central Florida were collected as part of the Together for Agricultural Safety (TAS) Project from 1999–2001. Univariate analyses and multivariate Ordinary Least Squares regression are used to examine the role of individual and structural characteristics on handwashing practices.ResultsWorkplace practices such as the provision of written notices of recent pesticide application and the provision of convenient handwashing facilities are important predictors of workplace hygiene. Although farmworker attitudes and beliefs towards the utility of such practices and potential hazards are associated with behavior, they are less significant than the structural variables.ConclusionsIn order for farmworkers to engage in safety behavior that will protect their health, they must be adequately instructed and supported by employers and/or supervisors. Am. J. Ind. Med. 53:814–824, 2010. © 2010 Wiley‐Liss, Inc.
Nonfatal construction industry‐related injuries treated in hospital emergency departments in the United States, 1998–2005
Authors: Schoenfisch Ashley L. , Lipscomb Hester J. , Shishlov Kirill , Myers Douglas J. 
Published: March 2010

AbstractBackgroundThis study documented the burden of nonfatal construction industry work‐related injuries treated in hospital emergency departments in the United States (US) from 1998 through 2005 and described injured worker demographics and injury characteristics.MethodsData from the National Electronic Injury Surveillance System work‐related injury supplement (NEISS‐Work) were used to identify and describe construction industry‐related injuries. Rates were estimated using data from the Current Population Survey.ResultsAn estimated 3,216,800 (95% CI 2,241,400–4,192,200) construction industry‐related injuries were seen in US emergency departments during the 8‐year period; this represented an injury rate of 410/10,000 full‐time equivalents and suggests that there are a greater number of construction injuries than reported through the Bureau of Labor Statistics' Survey of Occupational Injuries and Illnesses (BLS SOII). Common characteristics included diagnoses of laceration, sprain/strain, and contusion/abrasion; events of contact with an object/equipment, bodily reaction/exertion, and falls; and sources of injury of parts/materials; structures/surfaces; and tools/instruments/equipment. The upper extremities were most often affected.ConclusionsThese data highlight the high burden of nonfatal construction industry‐related injuries. The limitations of national occupational injury data sources inherent in relying on OSHA logs highlight the utility of NEISS‐Work data in occupational injury research. While data captured from emergency departments are not immune to factors that influence whether a worker or an employer reports an injury as work‐related or files a workers' compensation claim, emergency department data as collected through NEISS‐Work do not rely on employer involvement in order to be classified as work‐related. Am. J. Ind. Med. 53: 570–580, 2010. Published 2010 Wiley‐Liss, Inc.
Case–control association study of TGOLN2 in attempted suicide
Authors: Mahon Pamela B. , Stütz Adrian M. , Seifuddin Fayaz , Huo Yuqing , Goes Fernando S. , Jancic Dubravka , Judy Jennifer T. , DePaulo J. Raymond , Gershon Elliot S. , McMahon Francis J. , Zandi Peter P. , Potash James B. , Willour Virginia L. 
Published: March 2010

AbstractFamily, twin, and adoption studies provide convincing evidence for a genetic contribution to suicidal behavior. The heritability for suicidal behavior depends in part on the transmission of psychiatric disorders, such as mood disorders and substance use disorders, but is also partly independent of them. Three linkage studies using the attempted suicide phenotype in pedigrees with bipolar disorder, major depression, or alcoholism have provided consistent evidence that 2p11‐12 harbors a susceptibility gene for attempted suicide. A microarray expression study using postmortem brain samples has implicated a gene from the 2p11‐12 candidate region, the trans‐Golgi network protein 2 (TGOLN2) gene, as being consistently up‐regulated in suicide cases as compared to controls. Here, we present a TGOLN2 case–control association study using nine single nucleotide polymorphisms (SNPs). These nine SNPs, which include seven tag SNPs and two coding SNPs, have been genotyped in 517 mood disorder subjects with a history of attempted suicide and 515 normal controls. Allelic and genotypic analyses of the case–control sample did not provide evidence for association with the attempted suicide phenotype. Eight of the nine SNPs provided supportive evidence for association (P‐values ranging from 0.008 to 0.03) when we compared the attempted suicide cases with a history of alcoholism to the attempted suicide cases without a history of alcoholism. However, this association finding was not replicated in an independent sample. Taken together, these analyses do not provide support for the hypothesis that common genetic variation in TGOLN2 contributes significantly to the risk for attempted suicide in subjects with major mood disorders. © 2010 Wiley‐Liss, Inc.
Genetic pathway‐based hierarchical clustering analysis of older adults with cognitive complaints and amnestic mild cognitive impairment using clinical and neuroimaging phenotypes
Authors: Sloan Chantel D. , Shen Li , West John D. , Wishart Heather A. , Flashman Laura A. , Rabin Laura A. , Santulli Robert B. , Guerin Stephen J. , Rhodes C. Harker , Tsongalis Gregory J. , McAllister Thomas W. , Ahles Tim A. , Lee Stephen L. , Moore Jason H. , Saykin Andrew J. 
Published: March 2010

AbstractHierarchical clustering is frequently used for grouping results in expression or haplotype analyses. These methods can elucidate patterns between measures that can then be applied to discerning their validity in discriminating between experimental conditions. Here a hierarchical clustering method is used to analyze the results of an imaging genetics study using multiple brain morphology and cognitive testing endpoints for older adults with amnestic mild cognitive impairment (MCI) or cognitive complaints (CC) compared to healthy controls (HC). The single nucleotide polymorphisms (SNPs) are a subset of those included on a larger array that are found in a reported Alzheimer's disease (AD) and neurodegeneration pathway. The results indicate that genetic models within the endpoints cluster together, while there are 4 distinct sets of SNPs that differentiate between the endpoints, with most significant results associated with morphology endpoints rather than cognitive testing of patients' reported symptoms. The genes found in at least one cluster are ABCB1, APBA1, BACE1, BACE2, BCL2, BCL2L1, CASP7, CHAT, CST3, DRD3, DRD5, IL6, LRP1, NAT1, and PSEN2. The greater associations with morphology endpoints suggests that changes in brain structure can be influenced by an individual's genetic background in the absence of dementia and in some cases (Cognitive Complaints group) even without those effects necessarily being detectable on commonly used clinical tests of cognition. The results are consistent with polygenic influences on early neurodegenerative changes and demonstrate the effectiveness of hierarchical clustering in identifying genetic associations among multiple related phenotypic endpoints. © 2010 Wiley‐Liss, Inc.
Characterization of valproic acid‐initiated homologous recombination
Authors: Sha Kevin , Winn Louise M. 
Published: March 2010

AbstractBACKGROUND: Valproic acid (VPA) is a frequently used antiepileptic agent and known teratogen. Previous research suggests that inhibition of histone deacetylases (HDACs) may play a role in VPA‐induced teratogenicity. We have also shown that VPA exposure leads to both an increase in reactive oxygen species (ROS) production and increased frequency of homologous recombination (HR). METHODS: In the present study, we evaluated the role of HDAC inhibition in VPA‐initiated HR to determine if HDAC inhibition could alter repair activity and/or cause DNA double‐strand breaks (DSBs), which would then initiate repair. Histone acetylation status was assessed to determine if VPA exposure led to HDAC inhibition in CHO 33 cells. RESULTS: Our results demonstrate that VPA (5 mM) exposure leads to increased acetylated histone H3 and H4 protein levels after 10 to 24 hr. Secondly, in our recombination assay where an artificial DNA DSB was induced in CHO 33 cells to assess repair activity, VPA exposure did not affect the repair activity of VPA‐initiated HR. Subsequently, to determine if VPA could increase susceptibility to DNA DSBs, the number of γ‐H2AX foci was assessed using immunocytochemistry and results revealed an increase in γ‐H2AX foci after 10‐ to 24‐hr exposure to VPA. CONCLUSIONS: Although we demonstrated the protective effect of polyethylene glycol‐catalase against VPA‐induced HR and the generation of intracellular ROS within 24 hr, we did not observed an increase in DNA oxidation. These studies suggest that HDAC inhibition and ROS signaling may play roles in DNA maintenance and cell‐cycle arrest in initiating DNA damage and repair. Birth Defects Res (Part B) 89:124–132, 2010. © 2010 Wiley‐Liss, Inc.
Metal–Organic Frameworks with Exceptionally High Methane Uptake: Where and How is Methane Stored?
Authors: Wu Hui , Simmons Jason M. , Liu Yun , Brown Craig M. , Wang Xi‐Sen , Ma Shengqian , Peterson Vanessa K. , Southon Peter D. , Kepert Cameron J. , Zhou Hong‐Cai , Yildirim Taner , Zhou Wei 
Published: March 2010

AbstractMetal–organic frameworks (MOFs) are a novel family of physisorptive materials that have exhibited great promise for methane storage. So far, a detailed understanding of their methane adsorption mechanism is still scarce. Herein, we report a comprehensive mechanistic study of methane storage in three milestone MOF compounds (HKUST‐1, PCN‐11, and PCN‐14) the CH4 storage capacities of which are among the highest reported so far among all porous materials. The three MOFs consist of the same dicopper paddlewheel secondary building units, but contain different organic linkers, leading to cagelike pores with various sizes and geometries. From neutron powder diffraction experiments and accurate data analysis, assisted by grand canonical Monte Carlo (GCMC) simulations and DFT calculations, we unambiguously revealed the exact locations of the stored methane molecules in these MOF materials. We found that methane uptake takes place primarily at two types of strong adsorption site: 1) the open Cu coordination sites, which exhibit enhanced Coulomb attraction toward methane, and 2) the van der Waals potential pocket sites, in which the total dispersive interactions are enhanced due to the molecule being in contact with multiple “surfaces”. Interestingly, the enhanced van der Waals sites are present exclusively in small cages and at the windows to these cages, whereas large cages with relatively flat pore surfaces bind very little methane. Our results suggest that further, rational development of new MOF compounds for methane storage applications should focus on enriching open metal sites, increasing the volume percentage of accessible small cages and channels, and minimizing the fraction of large pores.
The Impact of Amino Acid Side Chain Mutations in Conformational Design of Peptides and Proteins
Authors: Laufer Burkhardt , Frank Andreas O. , Chatterjee Jayanta , Neubauer Thomas , Mas‐Moruno Carles , Kummerlöwe Grit , Kessler Horst 
Published: March 2010

AbstractLocal energetic effects of amino acid replacements are often considered to have only a moderate influence on the backbone conformation of proteins or peptides. As these effects are difficult to determine experimentally, no comparison has yet been performed. However, knowledge of the influence of side chain mutations is essential in protein homology modeling and in optimizing biologically active peptide ligands in medicinal chemistry. Furthermore, the tool ofN‐methylation of peptides is of increasing importance for the design of peptidic drugs to gain oral availability or receptor selectivity. However,N‐methylation is often accompanied by considerable population ofcis‐peptide bond structures, resulting in completely different conformations compared with the parent peptide. To retain a favored structure, it might be important to understand the effect of different side chains on the backbone conformation and to enable the introduction of anN‐methylation at the right position without disturbing a biologically active conformation. In order to detect even small energetic effects due to side chain mutations, we employed a trick to investigate the structural equilibrium of a selected cyclic pentapeptide in which two conformations are equally populated. Very small energetic differences between both conformations could easily be determined experimentally by identifying shifts in the population of both isomers.
Molecular Dynamics Simulation of Interaction between Calcite Crystal and Phosphonic Acid Molecules
Authors: Zeng Jianping , Zhang Shuguang , Gong Xuedong , Wang Fengyun 
Published: March 2010

AbstractThe interactions between calcite crystal and seven kinds of phosphonic acids, nitrilotris(methylphosphonic acid) (NTMP), nitrilo‐methyl‐bis(methylphosphonic acid) (NMBMP), N,N‐glycine‐bis(methylphosphonic acid) (GBMP), 1‐ hydroxy‐1,1‐ethylenebis(phosphonic acid) (HEBP), 1‐amino‐1,1‐ethylenebis(phosphonic acid) (AEBP), 1,2‐ethylenediamine‐N,N,N′,N′‐tetrakis(methylphosphonic acid) (EDATMP), and 1,6‐hexylenediamine‐N,N,N′,N′‐tetrakis‐ (methylphosphonic acid) (HDATMP) have been simulated by a molecular dynamics method. The results showed that the binding energy of each scale inhibitor with the (1l̄0) (1l̄0) face of calcite crystal was higher than that with (104) face, which has been approved by the analysis of pair correlation functions. The sequence of scale inhibition efficiencies for phosphonic acids against calcite scale is as follows: EDATMP>HDATMP>HEBP>NTMP>GBMP>HEBP>NMBMP, and the growth inhibition on the (1l̄0) face of calcite was at the leading status. Phosphonic acids deformed during the binding process, and electrovalent bonds formed between the phosphoryl oxygen atoms in phosphonic acids and the calcium ions on calcite crystal.
Acoustical Properties of Binary Mixtures of Heptane with Ethyl Acetate or Butyl Acetate
Authors: Shukla Divya , Singh Shashi , Parveen Shahla , Gupta Manisha , Shukla Jagdish Prasad 
Published: March 2010

AbstractMixed solvents rather than single pure liquids are of utmost practical importance in chemical and industrial processes as they provide an ample opportunity for the continuous adjustment of desired properties of the medium. Therefore, ultrasonic velocity (u) and density (ρ) were measured for the binary mixtures formed by heptane with ethyl acetate or butyl acetate at temperatures 293, 298 and 303 K over the entire composition range. Deviation in ultrasonic velocity (Δu), deviation in isentropic compressibility (Δκs), and excess intermolecular free length (LEf) have been evaluated using the ultrasonic velocity data and the computed results were fitted to the Redlich‐Kister polynomial equation. The values of Δu, Δκs and LEf were plotted against the molar fraction of heptane. The observed positive and negative values of excess parameters were discussed in terms of molecular interaction between the components of the mixtures. Experimental values of ultrasonic velocity and density were compared with the results obtained by theoretical estimation procedures. The results were discussed in terms of average absolute deviation (AAD).
Syntheses, Structures and Thermal Stabilities of Three Novel Lanthanide Coordination Polymers with 6‐Hydroxynicotinic Acid
Authors: Guo Zhenling , Chen Sanping , Yang Qi , Gao Shengli 
Published: March 2010

AbstractThree novel lanthanide coordination polymers {[Ce2(HOnic)4(Onic)2(H2O)2]·6H2O}n (1), {[Ln(HOnic)(Onic)‐ (H2O)5·(HOnicH)]·H2O}n [HOnicH=6‐hydroxynicotinic acid, Ln=Nd (2), Pr (3)] have been synthesized and characterized by elemental analyses, IR spectrum and single crystal X‐ray diffraction. Structure analyses reveal that 1 features a 2D plane structure while compounds 2 and 3 possess a 1D chain‐like polymeric structure. TG analyses indicate that 1 exhibits higher thermostability than 2 and 3, which was attributed to the layer polymeric structure of 1.