bluuebunny/crossref_metadata_2025_split huggingface dataset:
ChemInform Abstract: Limodissimin A (I): A New Dimeric Coumarin from Limonia acidissima.
Authors: Kim Ki Hyun , Ha Sang Keun , Kim Sun Yeou , Kim Sung Hoon , Lee Kang Ro 
Published: January 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: A New Benzoxepin Metabolite Isolated from Endophytic Fungus Phomopsis sp.
Authors: Shiono Yoshihito , Nitto Ayumi , Shimanuki Keiko , Koseki Takuya , Murayama Tetsuya , Miyakawa Tokichi , Yoshida Jun , Kimura Ken‐ichi 
Published: January 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Discovery of the Imidazo[1,5‐a][1,2,4]‐triazolo[1,5‐d][1,4]benzodiazepine Scaffold as a Novel, Potent and Selective GABAA α5 Inverse Agonist Series.
Authors: Thomas Andrew W. , et al. et al. 
Published: January 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Gold Nanoparticles: Past, Present, and Future
Authors: Sardar Rajesh , Funston Alison M. , Mulvaney Paul , Murray Royce W. 
Published: January 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Adsorbent Materials for Carbon Dioxide Capture from Large Anthropogenic Point Sources
Authors: Choi Sunho , Drese Jeffrey H. , Jones Christopher W. 
Published: January 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: A Review of Chloride Assisted Copper Sulfide Leaching Oxygenated Sulfuric Acid and Mechanistic Considerations
Authors: Senanayake G. 
Published: January 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Molecular Monolayers on Silicon Surfaces
Authors: Lopinski Gregory P. , Wayner Daniel D. M. 
Published: January 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Bulk Metallic Glasses with Functional Physical Properties
Authors: Wang W. H. 
Published: January 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Biotransformation of Terpenoids: A Green Alternative for Producing Molecules with Pharmacological Activity
Authors: Simeo Y. , Sinisterra J. V. 
Published: January 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Transformations of (Organo)silicon Compounds Catalyzed by Iridium Complexes
Authors: Marciniec Bogdan , Kownacki Ireneusz 
Published: January 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Complexation of Porphyrins with Ions and Organic Molecules
Authors: Mamardashvili N. Zh. , Borovkov V. V. , Mamardashvili G. M. , Inoue Y. , Koifman O. I. 
Published: January 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Hydroxylamine, Oximate and Hydroxamate as α‐Nucleophiles in Dephosphorylation
Authors: Buncel Erwin , Um I. K. Hwan , Terrier Francois 
Published: January 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Reaction Mechanisms. Part 3. Polar Reactions
Authors: O'Donoghue AnnMarie C. , Isanbor Chukwuemeka 
Published: January 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Self‐Immolative Dendrimers Based on Quinone Methides
Authors: Erez Rotem , Shabat Doron 
Published: January 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Photochemical Generation and Characterization of Quinone Methides
Authors: Lukeman Matthew 
Published: January 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Hydrocarbon Oxygenations with Peroxides Catalyzed by Metal Compounds
Authors: Shul'pin Georgiy B. 
Published: January 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Iridium‐Catalyzed Asymmetric Allylic Substitutions
Authors: Helmchen Guenter 
Published: January 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Organometallic Complexes of Polypyridine Ligands. Part 5. Their Analogues, and N,O(S)‐Chelating Pyridines
Authors: Sadimenko Alexander P. 
Published: January 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Development of Glycoside Bond Formation Reactions and Their Applications to the Synthesis of Novel Biologically Active Nucleosides
Authors: Yoshimura Yuichi , Takahata Hiroki 
Published: January 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Squaraine Dyes in Molecular Recognition and Self‐Assembly
Authors: McEwen Johnathan J. , Wallace Karl J. 
Published: January 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Trafficking of Heme and Porphyrins in Metazoa
Authors: Severance Scott , Hamza Iqbal 
Published: January 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: In situ Imaging of Metals in Cells and Tissues
Authors: McRae Reagen , Bagchi Pritha , Sumalekshmy S. , Fahrni Christoph J. 
Published: January 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Manganese‐Induced Dopaminergic Neurodegeneration: Insights into Mechanisms and Genetics Shared with Parkinson′s Disease
Authors: Benedetto Alexandre , Au Catherine , Aschenr Michael 
Published: January 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Medicinal Inorganic Chemistry Approaches to Passivation and Removal of Aberrant Metal Ions in Disease
Authors: Scott Lauren E. , Orvig Chris 
Published: January 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Platinum Drug Distribution in Cancer Cells and Tumors
Authors: Klein Alice V. , Hambley Trevor W. 
Published: January 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Nucleic Acid Bases in the Gas Phase
Authors: Caminati Walther 
Published: January 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Assessing the Accuracy of Protein Structures by Quantum Mechanical Computations of 13Cα Chemical Shifts
Authors: Vila Jorge A. , Scheraga Harold A. 
Published: January 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Recent Developments in the Structural Characterization of Substituted meso‐Tetraarylporphyrins by Electrospray Tandem Mass Spectrometry
Authors: Domingues M. Rosario M. , Domingues Pedro , Neves Maria G. P. M. S. , Tome Augusto C. , Cavaleiro Jose A. S. 
Published: January 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Photochromic Diarylethene Molecules and Crystals
Authors: Irie Masahiro , Morimoto Masakazu 
Published: January 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Inv acts as a molecular anchor for Nphp3 and Nek8 in the proximal segment of primary cilia
Authors: Shiba Dai , Manning Danielle K. , Koga Hisashi , Beier David R. , Yokoyama Takahiko 
Published: January 2010

AbstractA primary cilium is an antenna‐like structure extending from the surface of most vertebrate cells. It is structurally divided along its vertical axis into sub‐compartments that include the ciliary tip, the shaft, the ciliary necklace segment, the transitional zone and the basal body. We recently discovered that the shaft of the primary cilia has a distinct molecular compartment, termed the “Inv compartment”, which is characterized by the accumulation of Inv at the base of primary cilia. Inv was discovered as a causative gene in inv mutant mice. It was later found to be responsible for the infantile type of nephronophthisis (NPHP2). Nephronophthisis (NPHP) is an autosomal recessive kidney disease. Nine causative genes have been identified, with all examined products thought to function in cilia, basal body and/or centrioles. However, their exact intra‐ciliary localization and relationship have not been clear. Here, we report that products of Nphp3 and Nek8 (the mouse orthologs of the causative genes for NPHP3 and NPHP9, respectively) localize to the Inv compartment. We also show that Inv is essential for the compartmental localization of Nphp3 and Nek8, whereas localization of Inv does not require Nphp3 or Nek8. Nphp1 and Nphp4 also localize at the proximal region of the cilium, but not in Inv compartment. Our results indicate that Inv acts as an anchor for Nphp3 and Nek8 in the Inv compartment, and suggest that Inv compartment is a candidate site for intra‐ciliary interaction of Inv, Nphp3 and Nek8. © 2010 Wiley‐Liss, Inc.
Epidermal growth factor receptor expression in breast cancer association with biologic phenotype and clinical outcomes
Authors: Rimawi Mothaffar F. , Shetty Priya B. , Weiss Heidi L. , Schiff Rachel , Osborne C. Kent , Chamness Gary C. , Elledge Richard M. 
Published: January 2010

AbstractBACKGROUND:Epidermal growth factor receptor (EGFR) expression is associated with aggressive phenotypes in preclinical breast cancer models, but in clinical studies, EGFR has been inconsistently linked to poor outcome. We hypothesized that EGFR expression in human breast tumors, when centrally and uniformly assessed, is associated with an aggressive phenotype and resistance to systemic therapy.METHODS:In a database of 47,286 patients with breast cancer, EGFR status was known on 2567 tumors. EGFR levels were measured centrally by ligand binding assay, and tumors with ≥10 fmol/mg were prospectively deemed positive. Clinical and biological features of EGFR‐positive and EGFR‐negative tumors were compared. Clinical outcomes were assessed by systemic therapy status.RESULTS:Of 2567 tumors, 475 (18%) were EGFR positive. EGFR‐positive tumors were more common in younger and in black women, were larger, had a higher S‐phase fraction, and were more likely to be aneuploid. EGFR‐positive tumors were more likely to be HER2‐positive (26% vs 16%, P < .0001), but less likely to be estrogen receptor‐positive (60% vs 88%, P < .0001) or progesterone receptor‐positive (26% vs 65%, P < .0001). In multivariate analyses, EGFR expression independently correlated with worse disease‐free survival (hazard ratio [HR] = 1.66; 95% confidence interval [CI], 1.4‐2.41, P = .007) and overall survival (HR = 1.98, 95% CI, 1.36‐2.88, P = .0004) in treated patients, but not in untreated patients.CONCLUSIONS:EGFR expression is more common in breast tumors in younger and black women. It is associated with lower hormone receptor levels, higher proliferation, genomic instability, and HER2 overexpression. It is correlated with higher risk of relapse in patients receiving adjuvant treatment. Blocking EGFR may improve outcome in selected patients. Cancer 2010. © 2010 American Cancer Society.
Survival outcomes with the use of surgery in limited‐stage small cell lung cancer
Authors: Schreiber David , Rineer Justin , Weedon Jeremy , Vongtama Dan , Wortham Angela , Kim Anne , Han Peter , Choi Kwang , Rotman Marvin 
Published: January 2010

AbstractBACKGROUND:Although chemotherapy and radiation therapy currently are recommended in limited‐stage small cell lung cancer (L‐SCLC), several small series have reported favorable survival outcomes in patients who underwent surgical resection. The authors of this report used a US population‐based database to determine survival outcomes of patients who underwent surgery.METHODS:The Surveillance, Epidemiology, and End Results (SEER) registry was used to identify patients who were diagnosed with L‐SCLC between 1988 and 2002 coded by SEER as localized disease (T1‐T2Nx‐N0) or regional disease (T3‐T4Nx‐N0). Kaplan‐Meier and Cox regression analyses were used to compare overall survival (OS) for all patients.RESULTS:In total, 14,179 patients were identified, including 863 patients who underwent surgical resection. Surgery was associated more commonly with T1/T2 disease (P < .001). Surgery was associated with improved survival for both localized disease and regional disease with improvements in median survival from 15 months to 42 months (P < .001) and from 12 months to 22 months (P < .001), respectively. Lobectomy was associated with the best outcome (P < .001). Patients with localized disease who underwent lobectomy with had a median survival of 65 months and a 5‐year OS rate of 52.6%; whereas patients who had regional disease had a median survival of 25 months and a 5‐year OS rate of 31.8%. On multivariate analysis, the benefit of surgery varied in a time‐dependant fashion. However, the benefit of lobectomy remained across all time intervals (P = .002).CONCLUSIONS:The use of surgery, and particularly lobectomy, in selected patients with L‐SCLC was associated with improved survival outcomes. Future prospective studies should consider the role of surgery as part of the multimodality management of this disease. Cancer 2010. © 2010 American Cancer Society.
Safety and efficacy results of the advanced renal cell carcinoma sorafenib expanded access program in North America
Authors: Stadler Walter M. , Figlin Robert A. , McDermott David F. , Dutcher Janice P. , Knox Jennifer J. , Miller Wilson H. , Hainsworth John D. , Henderson Charles A. , George Jeffrey R. , Hajdenberg Julio , Kindwall‐Keller Tamila L. , Ernstoff Marc S. , Drabkin Harry A. , Curti Brendan D. , Chu Luis , Ryan Christopher W. , Hotte Sebastien J. , Xia Chenghua , Cupit Lisa , Bukowski Ronald M. 
Published: January 2010

AbstractBACKGROUND:The Advanced Renal Cell Carcinoma Sorafenib (ARCCS) program made sorafenib available to patients with advanced renal cell carcinoma (RCC) before regulatory approval.METHODS:In this nonrandomized, open‐label expanded access program, 2504 patients from the United States and Canada were treated with oral sorafenib 400 mg twice daily. Safety and efficacy were explored overall and in subgroups of patients including those with no prior therapy, nonclear cell (nonclear cell) RCC, brain metastases, prior bevacizumab treatment, and elderly patients. Sorafenib was approved for RCC 6 months after study initiation, at which time patients with no prior therapy or with nonclear cell RCC could enroll in an extension protocol for continued assessment for a period of 6 months.RESULTS:The most common grade ≥2 drug‐related adverse events were hand‐foot skin reaction (18%), rash (14%), hypertension (12%), and fatigue (11%). In the 1891 patients evaluable for response, complete response was observed in 1 patient, partial response in 67 patients (4%), and stable disease for at least 8 weeks in 1511 patients (80%). Median progression‐free survival in the extension population was 36 weeks (95% confidence interval [CI], 33‐45 weeks; censorship rate, 56%); median overall survival in the entire population was 50 weeks (95% CI, 46‐52 weeks; censorship rate, 63%). The efficacy and safety results were similar across the subgroups.CONCLUSIONS:Sorafenib 400 mg twice daily demonstrated activity and a clinically acceptable toxicity profile in all patient subsets enrolled in the ARCCS expanded access program (clinicaltrials.gov identifier: NCT00111020). Cancer 2010. © 2010 American Cancer Society.
Scanning Electron Microscopy Investigation of Molecular Transport and Reactivity within Polymer Brushes
Authors: Matrab Tarik , Hauquier Fanny , Combellas Catherine , Kanoufi Frédéric 
Published: January 2010

AbstractScanning electrochemical microscopy (SECM) allows investigation of the transport of redox probes within polymer brushes grown by atom‐transfer radical polymerization (ATRP) from gold electrodes. By combination with cyclic voltammetry, the permeation of aqueous or organic redox probes is described and quantified in poly(glycidyl methacrylate) (PGMA) and polystyrene (PS). It is related to the chemical nature of both the probe and its environment (the solvent and the polymer phases). This study anticipates the permeation of reactive species within polymer brushes for further etching. The SECM reductive etching of the terminal CBr bond of PGMA or PS macroinitiator layers is then investigated for different polymer thicknesses. The incomplete reductive etching of the macroinitiator layers is in agreement with the low permeability of the etchant within such polymer brushes and with the distribution of the terminal CBr bonds throughout the brush. SECM proves to be a convenient tool for patterning such macroinitiator surfaces to form channels in block‐copolymer structures. The combination of both analytical and patterning investigations enables one to anticipate and understand the reactivity of grafted macromolecules.