bluuebunny/crossref_metadata_2025_split huggingface dataset:
Lay advisor interventions for hypertension outcomes: A Systematic Review, Meta-analysis and a RE-AIM evaluation
Authors: Patil Sonal J. , Bhayani Vishwa , Yoshida Yilin , Bushweller Leila , Udoh Eno-Obong , Todorov Irina , Saper Robert , Stange Kurt C. , Bolen Shari 
Published: May 2024

IntroductionLay advisor interventions improve hypertension outcomes; however, the added benefits and relevant factors for their widespread implementation into health systems are unknown. We performed a systematic review to: (1) summarize the benefits of adding lay advisors to interventions on hypertension outcomes, and (2) summarize factors associated with successful implementation in health systems using the Reach, Effectiveness, Adoption, Implementation, Maintenance (RE-AIM) framework.MethodsWe systematically searched several databases, including Ovid MEDLINE, CINAHL, PsycINFO from January 1981 to May 2023. All study designs of interventions delivered solely by lay advisors for adults with hypertension were eligible. If both arms received the lay advisor intervention, the study arm with lower intensity was assigned as the low-intensity intervention.ResultsWe included 41 articles, of which 22 were RCTs, from 7,267 screened citations. Studies predominantly included socially disadvantaged populations. Meta-analysis (9 RCTs; n = 4,220) of eligible lay advisor interventions reporting outcomes showed improved systolic blood pressure (BP) [−3.72 mm Hg (CI –6.1 to −1.3; I2 88%)], and diastolic BP [−1.7 mm Hg (CI −1 to −0.9; I2 7%)] compared to control group. Pooled effect from six RCTs (n = 3,277) comparing high-intensity with low-intensity lay advisor interventions showed improved systolic BP of −3.6 mm Hg (CI –6.7 to −0.5; I2 82.7%) and improved diastolic BP of −2.1 mm Hg (CI –3.7 to −0.4; I2 70.9%) with high-intensity interventions. No significant difference in pooled odds of hypertension control was noted between lay advisor intervention and control groups, or between high-intensity and low-intensity intervention groups. Most studies used multicomponent interventions with no stepped care elements or reporting of efficacious components. Indicators of external validity (adoption, implementation, maintenance) were infrequently reported.DiscussionLay advisor interventions improve hypertension outcomes, with high intensity interventions having a greater impact. Further studies need to identify successful intervention and implementation factors of multicomponent interventions for stepped upscaling within healthcare system settings as well as factors used to help sustain interventions.
Prognostic stratification of glioblastoma patients by unsupervised clustering of morphology patterns on whole slide images furthering our disease understanding
Authors: Baheti Bhakti , Innani Shubham , Nasrallah MacLean , Bakas Spyridon 
Published: May 2024

IntroductionGlioblastoma (GBM) is a highly aggressive malignant tumor of the central nervous system that displays varying molecular and morphological profiles, leading to challenging prognostic assessments. Stratifying GBM patients according to overall survival (OS) from H&amp;E-stained whole slide images (WSI) using advanced computational methods is challenging, but with direct clinical implications.MethodsThis work is focusing on GBM (IDH-wildtype, CNS WHO Gr.4) cases, identified from the TCGA-GBM and TCGA-LGG collections after considering the 2021 WHO classification criteria. The proposed approach starts with patch extraction in each WSI, followed by comprehensive patch-level curation to discard artifactual content, i.e., glass reflections, pen markings, dust on the slide, and tissue tearing. Each patch is then computationally described as a feature vector defined by a pre-trained VGG16 convolutional neural network. Principal component analysis provides a feature representation of reduced dimensionality, further facilitating identification of distinct groups of morphology patterns, via unsupervised k-means clustering.ResultsThe optimal number of clusters, according to cluster reproducibility and separability, is automatically determined based on the rand index and silhouette coefficient, respectively. Our proposed approach achieved prognostic stratification accuracy of 83.33% on a multi-institutional independent unseen hold-out test set with sensitivity and specificity of 83.33%.DiscussionWe hypothesize that the quantification of these clusters of morphology patterns, reflect the tumor's spatial heterogeneity and yield prognostic relevant information to distinguish between short and long survivors using a decision tree classifier. The interpretability analysis of the obtained results can contribute to furthering and quantifying our understanding of GBM and potentially improving our diagnostic and prognostic predictions.
How housing burden damages residents’ health: evidence from Chinese cities
Authors: Guo Xiaoxin , Zhong Shihu , Li Lin , Luo Manyi 
Published: May 2024

BackgroundCurrently, China is steadily pursuing high-quality development and promoting common prosperity, for which residents’ health is a precondition. However, high housing-price-to-income ratios and rent-to-income ratios have already triggered many social problems and have substantially affected people’s work and life. It is of practical significance to examine the relationship between housing burden and residents’ health.MethodsCombining city-level housing price-to-income ratio data and residents’ health data from the China Family Panel Studies, this study employs a binary logit model to investigate the impact and mechanism of housing burden on residents’ physical and psychological health.ResultsOverall, a 1% increase in the housing-price-to-income ratio leads to a 1.2% decrease in physical health and a 1.9% decrease in psychological health. In terms of different psychological state indicators, a 1% increase in the housing price-to-income ratio leads to a 1.1% increase in depression, 1.1% increase in nervousness, 1.4% increase in relentlessness, 1.4% increase in hopelessness, 1.0% increase in a sense of incapability, and 1.4% increase in meaninglessness. According to mechanistic analyses, a 1% increase in the housing-price-to-income ratio leads to increases of 0.6 and 0.7% in the smoking rate and late sleep rate, respectively, while it leads to a 0.9% decrease in the noon nap rate.ConclusionA growing housing burden significantly negatively impacts both the physical and psychological health of residents and increases the possibility of negative emotions. Further investigation revealed that the housing burden damages residents’ health by increasing their likelihood of smoking and sleeping late and decreasing their likelihood of taking a nap at noon, while exercise alleviates the negative impacts of the housing burden on residents’ physical and psychological health. Finally, we also find that housing burdens’ impacts on physical and psychological health differ significantly in terms of gender, age, and educational attainment. From the perspective of improving livelihoods, governments should consider the relationship between housing burdens and residents’ health when formulating livelihood policies. Location-specific and targeted policies should be followed. Additionally, efforts should be made to promote exercise among citizens.
High Blood Pressure and Its Associated Factors Among Aksum University Students, Northern Ethiopia, 2019: A Cross-Sectional Study
Authors: Gebremeskel Gebreamlak Gebremedhn , Haile Teklehaimanot Gereziher , Gebrewahd Gebremeskel Tukue , Tadesse Degena Bahrey 
Published: May 2024

Objectives:This study aimed to assess the burden of high blood pressure and its associated factors among students at Aksum University.Methods:A total of 240 participants were included; participants were selected through simple random sampling from May 2019 to July 2019. Logistic regression analysis was performed, with statistical significance set at a p-value &lt;0.05 and a 95% confidence level.Results:This study found that 17.9% of the participants had high blood pressure, with higher rates observed in males (62.79%) than in females (37.21%). Several factors were identified as associated with high blood pressure, including a family history of high blood pressure [AOR 1.72, 95% CI (1. 75–4.04)], regular physical exercise [AOR 0.64, 95% CI (0.30–0.94)], alcohol consumption [AOR 2.16, 95% CI (1.07–4.62)], tobacco smoking [AOR 5.46, 95% CI (1.98–15.07)], and central obesity [AOR 2.72, 95% CI (1.12–6.58)].Conclusion:This study reveals that one out of six students had high blood pressure. Factors such as a family history of high blood pressure, physical inactivity, tobacco smoking, and central obesity were associated with this condition.
Quantitative Analysis of Stress–Stretch Curves in Canine Lumbar Vertebrae Using Modified Logistic Functions
Authors: Kostenko Ernest , Stonkus Rimantas , Šengaut Jakov , Višniakov Nikolaj , Maknickas Algirdas 
Published: May 2024

Background: The mechanical characteristics of bone are crucial for comprehending its functionality and response to different load conditions, which are essential for advancing medical treatments, implants, and prosthetics. By employing mathematical modeling to analyze the mechanical properties of bone, we can assess stress and deformation under both normal and abnormal conditions. This analysis offers valuable perspectives on potential fracture risks, the effects of diseases, and the effectiveness of various treatments. Therefore, researchers are attempting to find an adequate mathematical description of the mechanical properties of bone. Methods: Experimental stress–stretch external loading curves were obtained through investigations of canine vertebrae. The obtained experimental curves were fitted using the SciPy Python library with a slightly modified logistic function (logistic function plus additional const). Results: The resulting coefficient of determination R2 (R squared) for most curves was near 0.999, indicating that an appropriate fitting function was selected for the description of the experimental stress–stretch curves. Conclusions: The stress–stretch behavior of canine vertebrae can be described using a logistic function modified by adding additional parameters for the most accurate fitting results.
Morphological and Molecular Analysis Identified a Subspecies of Crassostrea ariakensis (Fujita, 1913) along the Coast of Asia
Authors: Chen Ya , Li Cui , Lu Ruijing , Wang Haiyan 
Published: May 2024

Crassostrea ariakensis (Fujita, 1913) is one of the most important economic and ecological oysters that is naturally distributed along the coast of Asia, separated by the Yangtze River estuary. They are usually compared as different populations, while there is no consensus on whether C. ariakensis in northern and southern areas should be considered as two species or subspecies. Here, we analyzed morphological characteristics, COI, 16s rRNA, mitogenome sequences, and species delimitation analysis (ASAP and PTP) to resolve the intraspecific taxonomic status of the C. ariakensis. Phylogenetic and ASAP analysis highlight that C. ariakensis was divided into N-type and S-type. PTP was unable to differentiate between the two types of C. ariakensis. The divergence time of N-type and S-type C. ariakinsis is estimated to be 1.6 Mya, using the relaxed uncorrelated lognormal clock method. Additionally, significant morphological differences exist between the two groups in terms of the adductor muscle scar color. Despite these differences, the COI (0.6%) and 16S rRNA (0.6%) genetic distance differences between N-type and S-type C. ariakensis has not yet reached the interspecific level. These results suggest that N-type and S-type C. ariakensis should be treated as different subspecies and renamed as C. ariakensis ariakensis subsp. nov and C. ariakensis meridioyangtzensis subsp. nov.
Penerapan sistem distribusi pengairan otomatis berbasis teknologi IoT dalam pencegahan kekeringan pada tanaman cabe
Authors: Supria Supria , Zulkarnaen Zulkarnaen , Wahyat Wahyat , Faizi M. Nur 
Published: May 2024

Kelompok Tani Sejahtera Bersama memiliki 15 orang anggota kelompok yang berlokasi di Jl. Leseng Desa Sungai Alam Kecamatan Bengkalis Kabupaten Bengkalis. Dalam proses pertanian, ada beberapa hal yang harus dilakukan untuk mencapai target hasil pertanian yaitu pembibitan, penanaman, penyiraman (irigasi), pemupukan, perawatan, panen, dan lain-lain. Proses penyiraman atau irigasi saat ini masih dilakukan secara manual sehingga membutuhkan tenaga dan waktu serta kurangnya efisiensi pada proses pengairan pada tanaman cabai, sehingga mengakibatkan kurangnya kesuburan pada tanaman. Dari hasil survey yang dilakukan pada mitra Kelompok tani sejahtera bersama memiliki beberapa permasalahan antara lain metode pengairan masih menggunakan metode penyiraman manual sehingga menyebabkan distribusi air ke tanaman tidak seimbang, tingkat kelembapan pada tanah tidak bisa dimonitoring secara berkala dan menyebabkan ketidaksuburan pada tanah sebagai media tanam, menurunnya produksi dari panen diakibatkan tidak terpenuhinya asupan air dan tingkat kelembapan tanah yang berkurang pada musim kering. Untuk mengatasi masalah tersebut maka pada pengabdian ini akan melakukan suatu inovasi berbasis teknologi yang bisa meminimalisir terjadinya ketidakseimbangan asupan distribusi air ke tanaman cabe dan diharapkan bisa mengurangi dampak kekeringan pada cabe pada musim kering. Inovasi yang akan dikembangkan pada pengabdian ini adalah sebuah sistem pengairan secara otomatis dengan menggunakan teknologi IoT. Teknologi ini menggunakan sensor yang dapat mengukur tingkat kelembapan tanah pada media tanam sehingga secara otomatis terhubung ke mesin pompa air yang akan mengangkut air dari sumur galian ke media disitribusi air melalui pipa yang dirancang khusus dengan lubang untuk mengairi air ke tanaman, sistem ini disebut dengan sistem Irigasi Tetes.
KAJIAN PERANGKAT LUNAK AUTORESPONDER UNTUK PENGELOLAAN LEAD PADA WEB E-COMMERCE
Authors: Hendriadi Ade Andri 
Published: May 2024

Elektronik mail (e-mail) merupakan sarana komunikasi bagi seluruh pengguna Internet yang mudah dan efisien, sehingga dapat digunakan pada semua jenis sistem informasi termasuk Sistem Informasi Customer relationship management (CRM)Saat ini layanan push email tidak hanya dimiliki smartphone saja, tetapi handphone low-end juga banyak yang sudah mendukung push email. Penelitian ini mengembangkanintegrasi perangkat lunak autoresponder dengan web E-Commerce dengan memberikan layanan berupa pengiriman informasi pelanggan melalui attachment dari email yang dikirimkan secara otomatis (autorespond) kepada para pelanggan baru atau lama yang disimpan menggunakan fasilitas landing page yang teritegrasi dengan web E-commerce sebagai salah satu layanan Costumer Relationship Management. Dalam penelitian ini digunakan metode Rekaysa dengan pendekatan eksperi.men, dan dianalisis menggnakan beberapa tool statistika
Dyplomata Wazów wobec kobiet na dworach hiszpańskich – przypadek czy różnice kulturowo-społeczne?
Authors: Urjasz-Raczko Matylda 
Published: May 2024

Badania porównujące kulturę polityczną Zachodu i Rzeczypospolitej wykazały duże odmienności. Wskazuje na nie także praktyka postępowania długoletniego dyplomaty polskich Wazów, Stanisława Mąkowskiego, który przebywał na dworach hiszpańskich w Madrycie i w Neapolu w latach 1627–1655. Zabiegał przede wszystkim o tzw. sumy neapolitańskie. Można jednak postawić pytanie, czy jego zrozumienie funkcjonowania dworów hiszpańskich i przyjęta strategia działania były adekwatne do miejscowej specyfiki. Uwzględnienie kobiet dworu w strategii dyplomatycznej może służyć za swoisty barometr tej kwestii. Dyplomata nie miał łatwego zadania, z jednej strony musiał rozpoznać i działać wśród odmiennego od znanego sobie świata dworów hiszpańskich, z drugiej miał swego mocodawcę w Rzeczypospolitej, którego musiał przekonać do adekwatności podejmowanych przez siebie środków.
Sintesis Nanopartikel Perak Termodifikasi PEG-4000 Menggunakan Ekstrak Daun Afrika Sebagai Pendeteksi Hg2+
Authors: Asri Akbar Fikrah , Aritonang Henry Fonda , Koleangan Harry S. J. 
Published: May 2024

ABSTRACT
Synthesis of Ag nanoparticles was performed using modified African leaves of polyethylene glycol-4000 (PEG-4000) and further tested to qualitatively detect the presence of mercury ions (Hg2+) in water samples by colorimetry. Synthesis of Ag nanoparticles was carried out by dissolving 0.01 g of African leaf extract into AgNO3 solution (5; 10; 15; 20; and 25 mL) with the addition of PEG-4000 (5 ppm, 10 ppm, and 15 ppm). The particles were then stirred at 1500 rpm for 1 hour, and characterized using a UV-Vis spectrophotometer, Particle Size Analyzer (PSA), and Energy Dispersive Spectroscopy (EDS). The results showed that the synthesized Ag nanoparticles were 88.8 nm in size. PEG-4000 modified African leaf extract containing Ag nanoparticles was then used to detect Hg2+ ions which were observed colorimetrically. The results showed that the Ag nanoparticles contained in the African leaf extract and PEG-4000 could qualitatively detect the presence of Hg2+ metal ions in water samples.
Keywords: African leaf, Mercury (Hg2+) Detector, Ag Nanoparticles, Polyethylene Glycol-4000

ABSTRAK
Telah dilakukan sintesis nanopartikel Ag menggunakan daun afrika termodifikasi polietilen glikol-4000 (PEG-4000) dan selanjutnya diuji coba untuk mendeteksi secara kualitatif keberadaan ion merkuri (Hg2+) dalam sampel air secara kolorimetri. Sintesis nanopartikel Ag dilakukan dengan melarutkan 0,01 g ekstrak daun afrika ke dalam larutan AgNO3 (5; 10; 15; 20; dan 25 mL) dengan penambahan 2 mL PEG-4000 (5 ppm, 10 ppm dan 15 ppm). Selanjutnya distirer dengan kecepatan 1500 rpm selama 1 jam, dan dikarakterisasi menggunakan spektrofotometer UV-Vis, Particle Size Analyzer (PSA) dan Energy Dispersive Spectroscopy (EDS). Hasil penelitian menunjukkan bahwa nanopartikel Ag yang disintesis berukuran 88,8 nm. Ekstrak daun afrika yang termodifikasi PEG-4000 dan mengandung nanopartikel Ag ini kemudian digunakan untuk mendeteksi ion logam Hg2+ yang diamati secara kolorimetri. Hasil penelitian menunjukkan bahwa nanopartikel Ag yang terkandung dalam ekstrak daun afrika dan PEG-4000 secara kualitatif dapat mendeteksi keberadaan ion Hg2+ dalam sampel air.
Kata kunci: Daun afrika, Detektor Merkuri (Hg2+), Nanopartikel Ag, Polietilen Glikol-4000
A AUTOPERCEPÇÃO DE BRUXISMO E ANSIEDADE EM ACADÊMICOS DA ÁREA DA SAÚDE NO PERÍODO PÓS PANDÊMICO
Authors: Assunção Élida Lúcia Ferreira , Oliveira Fabíola Belkiss Santos , Franco Lucas Gabriel de Melo , Costa Giulia Emannuele Albuquerque , Amaral Bruna Maria Ribeiro , Patrícia Furtado Gonçalves  , Santos Júlia Maria Moreira 
Published: May 2024

Objetivo: O presente estudo teve como objetivo avaliar a frequência de bruxismo e ansiedade entre os acadêmicos da área da saúde do norte de Minas Gerais. Metodologia: Trata-se de um estudo quantitativo, transversal, exploratório, de análise descritiva de dados a ser realizado com acadêmicos de curso da área de saúde das instituições de ensino superior do Norte de Minas – MG (CEP/FUNORTE: nº 6.253.249). Resultados: A amostra foi formada por 108 participantes, na qual houve predominância do sexo feminino, com idade média de 22,69 anos. A frequência do apertamento dental (78,7%) foi maior do que a percepção do bruxismo noturno (46,3%). Para maioria o hábito está relacionado a fatores estressantes, mas não se recordam em que momento começaram a apresentar a parafunção. Discussão: Sugere-se que a sobrecarga emocional, estresse e ansiedade causados pelo novo contexto de pandemia impactou negativamente na saúde mental dos acadêmicos da área da saúde, corroborando com o aumento da percepção de bruxismo desde o aumento da pandemia. Conclusão: Notou-se com o estudo que houve um aumento do hábito parafuncional no grupo de universitários da área da saúde, que pode estar relacionado ao estresse e ansiedade medido pelo instrumento IDATE.
REPERCUSSÃO DA DENGUE NO SISTEMA NERVOSO
Authors: Augusto Barbosa Pedro Augusto , Ricardo Petta Amanda , Zacarias Batista Costa Júnior Antonio , Ariete Vitorino Dias Soares Camilla , Tomoe Tatibana Tsutsui Cinthia , Clemenson da Silva Gemerson , Silva Athayde Gomes Inah , Maria Santana da Costa Izadora , De Pinho Antunes Larychelle , Vedovato Nicola Lucas , Luiza Lauth Marcela , Leal Jaccoud Mayara , Cardoso De Souza Rafaela , De Lima Rodrigues Thiago 
Published: May 2024

O vírus da dengue é transmitido pelo mosquito Aedes aegypti infectado. É uma das arboviroses mais presentes no mundo. Nota-se um aumento do número de casos no Brasil nos últimos anos, chegando há mais de 4 milhões de prováveis casos de dengue notificados apenas até o período de abril de 2024. As manifestações clínicas vão desde da forma assintomática, formas leves até complicações graves como choque e alterações neurológicas e morte. O objetivo do trabalho é analisar as possíveis manifestações da dengue no sistema nervoso central. Trata-se de uma revisão narrativa dos últimos 5 anos utilizando a base de dados: Medline, Índice Bibliográfico Espanhol em Ciências da Saúde (IBECS) e Literatura Latino-Americana e do Caribe em Ciências da Saúde(LILACS), somado a isso foi utilizado os dados do DATASUS referente às notificações registradas no sistema de informação de agravos de notificação da dengue no Brasil, do período de 2019 até o dia 29/04/2024. Evidenciou-se que a dengue pode apresentar manifestações neurológicas, principalmente, as encefalopatias e encefalite, além disso pode apresentar outras complicações, tal como mononeuropatia, síndrome de Guillain-Barré e encefalomielite disseminada aguda. Nessa perspectiva, notou-se a variedade de manifestações clínicas que a dengue pode acarretar no sistema nervoso, sendo importante medidas de prevenção e tratamento de suporte para evitar essas possíveis complicações.
Variant Analysis of XDR Salmonella Typhi Strains Using Global Alignment Tool Kit in South Asian Region
Authors: Niazi Maham , Mumtaz Zilwa , Ahmed Maqsood , Ahmed Saeed , Ali Ashaq , Yousaf Muhammad Zubair 
Published: May 2024

Objective: To concisely compare genomic profiles of XDR Salmonella Typhi isolates from Lahore withantimicrobial-resistant Salmonella Typhi isolates from other developing nations.Study Design: Comparative analysis of whole genome sequences.Place and Duration of Study: The study was conducted from December 2020 to September 2021 at KauserAbdulla Malik (KAM) School Life Sciences, Forman Christian College University, Lahore, Pakistan.Methods: The Galaxy pipeline was run to obtain detailed information at the nucleotide level regardingmutations that lead to the emergence of XDR strains. Whole genome sequences were analyzed to compare thegenomes of selected three developing nations.Results: The Pakistani isolates had a significantly higher mutation rate, higher proportion of modifiers, andsilent mutations as compared to isolates of Bangladesh and India.Conclusion: Cases of Salmonella Typhi XDR are rapidly rising in Asian countries such as Pakistan, Bangladesh,and India emphasizing the need to analyze and compare its genome with relevant strains. Our study highlightsthe unique profile of the Lahore (Pakistan) isolate with the highest mutation rate suggesting the potentialregional differences in selective pressure. Further spotlights the necessity to elucidate the functionalconsequences of the identified mutations in S. Typhi isolates.
How to cite this: Niaz M, Mumtaz Z, Ahmed M, Ahmad S, Ali A, Yousaf MZ. Variant Analysis of XDR Salmonella Typhi Strains Using Global Alignment Tool Kit in South Asian Region. Life and Science. 2024; 5(2): 244-250. doi: http://doi.org/10.37185/LnS.1.1.432