bluuebunny/crossref_metadata_2025_split huggingface dataset:
ChemInform Abstract: Envirocat (K10‐MX)‐Catalyzed Regioselective Transformation of Alkenes into Iodohydrins and β‐Iodo Ethers and Further Conversion of Iodohydrins to Epoxides Using Al2O3—Na2CO3 under MWI.
Authors: Shallu Shallu , Sharma M. L. , Singh Jasvinder 
Published: August 2012

AbstractEnvirocats, prepared by treating montmorillonite K10 clay with aqueous solutions of metal salts (MX), are found to be efficient catalysts for the regioselective formation of iodohydrins or related β‐iodo ethers from alkenes under microwave irradiations.
ChemInform Abstract: Formal Intramolecular [4 + 1]‐Cycloaddition of Dialkoxycarbenes: Control of the Stereoselectivity and a Mechanistic Portrait.
Authors: Beaumier Francis , Dupuis Marianne , Spino Claude , Legault Claude Y. 
Published: August 2012

AbstractA variety of electron‐deficient dienes bearing a 2,2‐dialkoxy‐Δ3‐1,3,4‐oxadiazoline moiety as source for the dialkoxycarbene is transformed to cyclopenta‐fused five‐, six‐, and seven‐membered O‐heterocyclic rings.
ChemInform Abstract: Facile Construction of [6,6]‐, [6,7]‐, [6,8]‐, and [6,9]Ring‐Fused Triazole Frameworks by Copper‐Catalyzed, Tandem, One‐Pot, Click and Intramolecular Arylation Reactions: Elaboration to Fused Pentacyclic Derivatives.
Authors: Reddy M. Nagarjuna , Swamy K. C. Kumara 
Published: August 2012

AbstractThe copper‐catalyzed click reaction of O‐alkynyl‐iodophenols with benzyl‐ or arylazides affords the triazole ring which is subsequently arylated to provide the title tricycles (36 examples).
ChemInform Abstract: WCl6 as an Efficient Heterogeneous and Reusable Catalyst for the Preparation of 14‐Aryl‐14H‐dibenzo[a,j]xanthenes with High TOF.
Authors: Zolfigol Mohammad Ali , Moosavi‐Zare Ahmad Reza , Arghavani‐Hadi Parastoo , Zare Abdolkarim , Khakyzadeh Vahid , Darvishi Ghasem 
Published: August 2012

AbstractThe present protocol is characterized by clean reactions, simple purification, short reaction times and, as compared to established methods, higher turn over frequencies.
ChemInform Abstract: Furanoside Phosphite—Phosphoroamidite and Diphosphoroamidite Ligands Applied to Asymmetric Cu‐Catalyzed Allylic Substitution Reactions.
Authors: Magre Marc , Mazuela Javier , Dieguez Montserrat , Pamies Oscar , Alexakis Alexandre 
Published: August 2012

AbstractThe best results are obtained with the shown ligand.
ChemInform Abstract: Trifluoromethanesulfonic Acid Promoted Dakin—West Reaction: An Efficient and Convenient Synthesis of β‐Acetamido Ketones.
Authors: Kumbhare Ravindra M. , Sridhar Madabhushi 
Published: August 2012

Abstractβ‐Acetamido ketones (IV) are obtained efficiently by condensation of an acetophenone with an aromatic aldehyde and acetonitrile in the presence of acetyl chloride and triflic acid as activators.
ChemInform Abstract: Palladium Nanoparticles on Thermoresponsive Hydrogels and Their Application as Recyclable Suzuki—Miyaura Coupling Reaction Catalysts in Water.
Authors: Hong Myeng Chan , Choi Myung Chan , Chang Young Wook , Lee Yongwoo , Kim Jongsik , Rhee Hakjune 
Published: August 2012

AbstractThe catalyst can be recycled and reused for at least ten runs without loss of activity.
ChemInform Abstract: Water‐Promoted One‐Pot Vinylogous Mannich‐Type Reaction of Trimethylsilyloxyfuran.
Authors: Landelle Gregory , Claraz Aurelie , Oudeyer Sylvain , Levacher Vincent 
Published: August 2012

AbstractThe formation of imines from aldehydes and amines generates water which promotes the one‐pot Mannich reaction of trimethylsilyloxyfuran under neat conditions.
ChemInform Abstract: Metal‐Free Tandem Friedel—Crafts/Lactonization Reaction to Benzofuranones Bearing a Quaternary Center at C‐3 Position.
Authors: Chen Long , Zhou Feng , Shi Tao‐Da , Zhou Jian 
Published: August 2012

Abstract3,3‐Diaryl‐ and 3‐alkyl‐3‐arylbenzofuranones are prepared with a high substitution pattern at the aromatic site, which allows further functionalization.
ChemInform Abstract: Phenyliodine Bis(trifluoroacetate)‐Mediated Oxidative C—C Bond Formation: Synthesis of 3‐Hydroxy‐2‐oxindoles and Spirooxindoles from Anilides.
Authors: Wang Junwei , Yuan Yucheng , Xiong Rui , Zhang‐Negrerie Daisy , Du Yunfei , Zhao Kang 
Published: August 2012

AbstractVarious anilides bearing an ethoxycarbonyl group as terminal function can be transformed to the desired 3‐ hydroxy‐2‐oxindole structures.
ChemInform Abstract: Preparation and Characterization of Aryl or Heteroaryl(3‐indolyl)methylium o‐Benzenedisulfonimides.
Authors: Barbero Margherita , Cadamuro Silvano , Cauda Fabrizio , Dughera Stefano , Gervasio Giuliana , Venturello Paolo 
Published: August 2012

AbstractTreatment of the indole (I) with aromatic aldehydes and the imine (II) allows access to new stable title compounds like (IV).
ChemInform Abstract: A Bifunctional Catalyst for Carbon Dioxide Fixation: Cooperative Double Activation of Epoxides for the Synthesis of Cyclic Carbonates.
Authors: Ema Tadashi , Miyazaki Yuki , Koyama Shohei , Yano Yuya , Sakai Takashi 
Published: August 2012

AbstractA highly active Mg‐porphyrin catalyst for the synthesis of cyclic carbonates from epoxides and CO2 under solvent‐free conditions showing a TON of up to 103000 is presented.
ChemInform Abstract: Straightforward One‐Pot Synthesis of Benzofuroxans from o‐Halonitrobenzenes in Ionic Liquids.
Authors: Sheremetev Aleksei B. , Aleksandrova Nataliya S. , Ignat'ev Nikolai V. , Schulte Michael 
Published: August 2012

AbstractTreatment of o‐halonitrobenzenes with sodium azide in an [empyrr] BF4/Bu4NBr/H2O system gives benzofuroxans in high yields.
ChemInform Abstract: “Ligand‐Free” Palladium‐Catalyzed Direct C—H Bond Oxidative Acyloxylation of 2‐Arylpyridines with Aromatic Carboxylic Acids.
Authors: Hu Chao‐Jun , Zhang Xiao‐Hong , Ding Qiu‐Ping , Lv Ting , Ge Shao‐Peng , Zhong Ping 
Published: August 2012

AbstractThe process gives ortho‐monoacyloxylated products selectively.
ChemInform Abstract: Discovery of S‐777469: An Orally Available CB2 Agonist as an Antipruritic Agent.
Authors: Odan Masahide , et al. et al. 
Published: August 2012

AbstractThe discovery of novel CB2 ligands based on 3‐carbamoyl‐2‐pyridone derivatives (I) by adjusting several positions is reported.
ChemInform Abstract: Iron‐Promoted Tandem Reaction of Anilines with Styrene Oxides via C—C Cleavage for the Synthesis of Quinolines.
Authors: Zhang Yicheng , Wang Min , Li Pinhua , Wang Lei 
Published: August 2012

AbstractThe title reaction produces selectively 3‐aryl derivatives with concomitant loss of one molecule of aryl aldehyde.
ChemInform Abstract: Copper‐Catalyzed Aerobic Intramolecular Carbo‐ and Amino‐Oxygenation of Alkynes for Synthesis of Azaheterocycles.
Authors: Toh Kah Kah , Sanjaya Stephen , Sahnoun Sophian , Chong Sin Yee , Chiba Shunsuke 
Published: August 2012

AbstractNo cyclization occurs if the alkyne moiety is substituted by an alkyl group.
ChemInform Abstract: Palladium‐Catalyzed Intermolecular Cyclocarbonylation of 2‐Iodoanilines with the Michael Acceptor, Diethyl Ethoxycarbonylbutendienoate.
Authors: Okuro Kazumi , Alper Howard 
Published: August 2012

AbstractHighly functionalized dihydroquinolines are formed if the triester (IIa) is used.
ChemInform Abstract: Metal‐Free TEMPO‐Catalyzed Oxidative C—C Bond Formation from Csp3—H Bonds Using Molecular Oxygen as the Oxidant.
Authors: Zhang Bo , Cui Yuxin , Jiao Ning 
Published: August 2012

AbstractThe title transformation, providing a simple and efficient approach to modify 9,10‐dihydroacridine derivatives at the 9 position, proceeds under mild and neutral conditions, even in the absence of solvents.
ChemInform Abstract: 4‐Amino‐5‐(arylaminomethyl)‐2‐(methylthio)furo[2,3‐d]pyrimidines via Mitsunobu Reaction of 4‐Amino‐5‐(hydroxymethyl)‐2‐(methylthio)furo[2,3‐d]pyrimidine with N‐Mesyl‐ and N‐Nosylarylamines.
Authors: Masevicius Viktoras , Petraityte Grazina , Tumkevicius Sigitas 
Published: August 2012

AbstractMitsunobu reaction of N‐nosyl and N‐mesylarylamines with pyrimidine (II) allows the introduction of various arylamino units.
ChemInform Abstract: Is CO2 Fixation Promoted Through the Formation of DBU Bicarbonate Salt?
Authors: Mizuno Takumi , Nakai Takeo , Mihara Masatoshi 
Published: August 2012

AbstractCarbonylation of o‐aminobenzonitriles (I) with CO2 in the presence of DBU bicarbonate salt at elevated temperatures affords quinazolinediones (III) in good to excellent yields.
ChemInform Abstract: Synthesis of Modified Uracil and Cytosine Nucleobases Using a Microwave‐Assisted Method.
Authors: Burgula Laxmi Narayana , Radhakrishnan K. , Kundu Lal Mohan 
Published: August 2012

AbstractThe reaction of β‐ketoesters (Ia‐c) or the aldehyde analogue (Id) with urea proceeds under microwave irradiation in the presence of BF3·OEt2 to yield nucleobases (III).
ChemInform Abstract: Preparation of Allyl and Vinyl Silanes by the Palladium‐Catalyzed Silylation of Terminal Olefins: A Silyl‐Heck Reaction.
Authors: McAtee Jesse R. , Martin Sara E. S. , Ahneman Derek T. , Johnson Keywan A. , Watson Donald A. 
Published: August 2012

AbstractThe use of BPP is the key for the title synthesis.
ChemInform Abstract: Solvent‐Free and Three‐Component Synthesis of 1H,6H‐6λ5‐[1,2]Benzoxaphospholo[2,3‐b] [1,2]benzoxaphosphol‐1‐ones.
Authors: Adib Mehdi , Sheikhi Ehsan , Bagheri Mehdi , Bijanzadeh Hamid Reza , Amanlou Masoud 
Published: August 2012

AbstractThe title compounds can be prepared via a one‐pot method without any activation or modification of the starting materials and reagents.
ChemInform Abstract: Unambiguous Structure of Atractyloside and Carboxyatractyloside.
Authors: Sanchez Jean‐Frederic , Kauffmann Brice , Grelard Axelle , Sanchez Corinne , Trezeguet Veronique , Huc Ivan , Lauquin Guy J.‐M. 
Published: August 2012

AbstractIn contrast to the hitherto controversial information about the glycon stereostructure in atractyloside (Ia) and carboxyatractyloside (Ib), the anomeric structure in both diterpenoid glycosides is unambiguously determined by X‐ray crystallography studies now.
ChemInform Abstract: Pimarane Diterpenes form the Fungus Epicoccum sp. HS‐1 Associated with Apostichopus japonicus.
Authors: Xia Xuekui , Zhang Jianye , Zhang Yonggang , Wei Fang , Liu Xin , Jia Airong , Liu Changheng , Li Wei , She Zhigang , Lin Yongcheng 
Published: August 2012

AbstractThree new pimarane diterpenes (I)—(III) and a known structurally related compound are isolated from the marine‐derived fungus HS‐1 associated with a sea cucumber.
ChemInform Abstract: Sinularioside, a Triacetylated Glycolipid from the Indonesian Soft Coral Sinularia sp., Is an Inhibitor of NO Release.
Authors: Putra Masteria Yunovilsa , Ianaro Angela , Panza Elisabetta , Bavestrello Giorgio , Cerrano Carlo , Fattorusso Ernesto , Taglialatela‐Scafati Orazio 
Published: August 2012

AbstractTitle compound (I) moderately inhibits LPS‐induced NO release, providing interesting insights into the poorly understood SAR for anti‐inflammatory glycolipids.
ChemInform Abstract: Fluorescent Nucleosides with “On‐Off” Switching Function, pH‐Responsive Fluorescent Uridine Derivatives.
Authors: Saito Yoshio , Miyamoto Shigenori , Suzuki Azusa , Matsumoto Katsuhiko , Ishihara Tsutomu , Saito Isao 
Published: August 2012

AbstractVarious pH‐responsive fluorescent deoxyuridine derivatives (I) are synthesized by Sonogashira cross‐coupling reactions.
Fires and Explosions within Risk Analysis
Authors: Hauptmanns Ulrich 
Published: August 2012

AbstractDie Vorgehensweise bei der Risikoermittlung wird anhand des Ereignisablaufs nach einer schlagartigen Freisetzung von gasförmigem Propylen behandelt. Die dazu erforderlichen Modelle für Feuerball, Gaswolkenfeuer und Explosion werden vorgestellt, ihre Unsicherheiten und Sensitivitäten werden diskutiert und anhand numerischer Beispiele verdeutlicht. Modellierungs‐ und Datenunsicherheiten sowie Unsicherheiten bei der Wahrscheinlichkeitsbewertung von Ereignisabläufen werden charakterisiert; ihre mathematische Behandlung wird gezeigt. Es werden deterministische und probabilistische Rechnungen durchgeführt und miteinander verglichen.
Endlagerung radioaktiver Abfälle
Authors: Geckeis Horst , Röhlig Klaus‐Jürgen , Mengel Kurt 
Published: August 2012

AbstractChemische Prozesse spielen im Endlager dann eine Rolle, wenn Wasser in den Endlagerbereich vordringt. Das Ausmaß einer möglichen Radionuklidfreisetzung wird durch eine Vielzahl von radio‐, geo‐ und biochemischen Reaktionen bestimmt. Im unmittelbaren Nahbereich der Abfälle beeinflussen im wesentlichen Radiolysereaktionen und Korrosion von Abfallformen, Behälter‐ und Versatzmaterialien das chemische Milieu. Im Fernfeld können freigesetzte Radionuklide mit gelösten und kolloidalen Grundwasserinhaltsstoffen sowie Mineraloberflächen wechselwirken. Für den Langzeitsicherheitsnachweis eines Endlagers wird mit Hilfe moderner experimenteller und theoretischer Methoden das chemische Verhalten von Abfallbestandteilen aufgeklärt und die Reaktionen durch thermodynamischen Daten quantifiziert.
Designing Multitarget Anti‐inflammatory Agents: Chemical Modulation of the Lumiracoxib Structure toward Dual Thromboxane Antagonists–COX‐2 Inhibitors
Authors: Bertinaria Massimo , Shaikh Mohammed Abrar Abdul Gaffar , Buccellati Carola , Cena Clara , Rolando Barbara , Lazzarato Loretta , Fruttero Roberta , Gasco Alberto , Hoxha Malvina , Capra Valérie , Sala Angelo , Rovati G. Enrico 
Published: August 2012

AbstractA series of lumiracoxib derivatives were designed to explore the influence of isosteric substitution on balancing COX‐2 inhibition and thromboxane A2 prostanoid (TP) receptor antagonism. The compounds were synthesized through a copper‐catalyzed coupling procedure and characterized for their pKa values. TP receptor antagonism was assessed on human platelets; COX‐2 inhibition was determined on human isolated monocytes and human whole blood. TPα receptor binding of the most promising compounds was evaluated through radioligand binding assays. Some of the isosteric substitutions at the carboxylic acid group afforded compounds with improved TP receptor antagonism; of these, a tetrazole derivative retained good COX‐2 inhibitory activity and selectivity. The identification of this tetrazole acting as a balanced dual‐acting compound in human whole blood, along with SAR analysis of the synthesized lumiracoxib derivatives, might contribute to the rational design of a new class of cardioprotective anti‐inflammatory agents.
Synthesis and Biological Evaluation of CTP Synthetase Inhibitors as Potential Agents for the Treatment of African Trypanosomiasis
Authors: Tamborini Lucia , Pinto Andrea , Smith Terry K. , Major Louise L. , Iannuzzi Maria C. , Cosconati Sandro , Marinelli Luciana , Novellino Ettore , Lo Presti Leonardo , Wong Pui E. , Barrett Michael P. , De Micheli Carlo , Conti Paola 
Published: August 2012

AbstractAcivicin analogues with an increased affinity for CTP synthetase (CTPS) were designed as potential new trypanocidal agents. The inhibitory activity against CTPS can be improved by increasing molecular complexity, by inserting groups able to establish additional interactions with the binding pocket of the enzyme. This strategy has been pursued with the synthesis of α‐amino‐substituted analogues of Acivicin and N1‐substituted pyrazoline derivatives. In general, there is direct correlation between the enzymatic activity and the in vitro anti‐trypanosomal efficacy of the derivatives studied here. However, this cannot be taken as a general rule, as other important factors may play a role, notably the ability of uptake/diffusion of the molecules into the trypanosomes.
Provider factors associated with disparities in human papillomavirus vaccination among low‐income 9‐ to 17‐year‐old girls
Authors: Vadaparampil Susan T. , Staras Stephanie A. S. , Malo Teri L. , Eddleton Katie Z. , Christie Juliette , Rodriguez Maria , Giuliano Anna R. , Shenkman Elizabeth A. 
Published: August 2012

AbstractBACKGROUND:Many women who develop cervical cancer are eligible for or are participants of Medicaid. Providing human papillomavirus (HPV) vaccination to girls enrolled in Medicaid may reduce cervical cancer disparities in low‐income and minority women. This study evaluated provider characteristics associated with HPV vaccination among 9‐ to 17‐year‐old female Medicaid enrollees.METHODS:A random sample of 800 providers from the Florida Medicaid Master Provider File was mailed a survey in October 2009 that evaluated demographic and practice characteristics, HPV information and knowledge, barriers to HPV vaccination, vaccine practices, and vaccine recommendation practices. To measure HPV vaccination, Medicaid claims data were used to calculate the proportion of eligible patients who received at least 1 dose of the vaccine from participating providers within the study period. Provider factors associated with vaccination at the bivariate level were evaluated in a multiple linear regression model.RESULTS:The response rate was 68.3% (N = 485). After excluding ineligible respondents, the current analysis included 433 providers. HPV vaccination prevalence ranged from 0% to 61.9% (M = 20.4, standard deviation = 14.5). HPV vaccination rates were higher among providers who were pediatricians, had a private practice, practiced in a single specialty setting, were providers under the Vaccines for Children program, saw primarily non‐Hispanic white patients, used 2 or more strategies for vaccine series completion, and did not refer out for HPV vaccination.CONCLUSIONS:Despite financial coverage for Medicaid‐eligible girls, HPV vaccination rates are low. Study findings can be used to target health services interventions to providers least likely to administer HPV vaccine to female Medicaid enrollees. Cancer 2013. © 2012 American Cancer Society.
Augmented Lagrange methods for quasi‐incompressible materials—Applications to soft biological tissue
Authors: Brinkhues S. , Klawonn A. , Rheinbach O. , Schröder J. 
Published: August 2012

SUMMARYArterial walls in the healthy physiological regime are characterized by quasi‐incompressible, anisotropic, hyperelastic material behavior. Polyconvex material functions representing such materials typically incorporate a penalty function to account for the incompressibility. Unfortunately, the penalty will affect the conditioning of the stiffness matrices. For high penalty parameters, the performance of iterative solvers will degrade, and when direct solvers are used, the quality of the solutions will deteriorate. In this paper, an augmented Lagrange approach is used to cope with the quasi‐incompressibility condition. Here, the penalty parameter can be chosen much smaller, and as a consequence, the arising linear systems of equations have better properties. An improved convergence is then observed for the finite element tearing and interconnecting–dual primal domain decomposition method, which is used as an iterative solver. Numerical results for an arterial geometry obtained from ultrasound imaging are presented. Copyright © 2012 John Wiley & Sons, Ltd.
Approaching object detector mouse retina circuit model analysis and implementation on cellular sensor‐processor array
Authors: Zarándy Ákos , Fülöp Tamás 
Published: August 2012

ABSTRACTApproaching object detector structure has been recently identified in mouse retina, and its neural circuit model has been successfully built. A discrete‐type mathematical model describing the retinal structure has been synthesized and implemented on a biologically motivated focal‐plane mixed‐signal sensor‐processor device. The model responses have been analyzed, and the critical parameters have been identified, and their roles were studied. The model has been validated in real dynamic surround of a robotic arm, where the geometrical and the kinematic parameters of the movements were known. From the mathematical and experimental analysis, it has been concluded that this retinal structure has a capacity to generate a last second warning signal to avoid collisions. Copyright © 2012 John Wiley & Sons, Ltd.
The expanding frontier of hematopoietic cell transplantation
Authors: Spitzer Thomas R. , Dey Bimalangshu R. , Chen Yi‐Bin , Attar Eyal , Ballen Karen K. 
Published: August 2012

AbstractOver the past several decades there has been a tremendous expansion of the indications for hematopoietic cell transplantation. This growth has been possible because of advances in supportive care, more effective graft versus host disease prophylaxis and the advent of reduced intensity conditioning regimens which have greatly reduced transplant related morbidity and allowed for the transplantation of older patients and patients with significant co‐morbid disease. The role of flow cytometry in transplantation is crucial to both clinical care, for accuracy of diagnosis and monitoring of disease, and research. In this review, we highlight some of the important advances that have been made in the field, including the use of alternative donors for transplantation, novel therapies for the myeloid malignancies, which remain the prototype diseases for transplantation, and advances in diagnosis and treatment of graft versus host disease, which is the principal complication of allogeneic hematopoietic cell transplantation. Future directions in hematopoietic cell transplantation, particularly those that attempt to modulate the post‐transplant cellular environment to favor separation of graft versus host disease from the graft versus tumor effects of the transplant are discussed. © 2012 International Clinical Cytometry Society
Homoploid hybrid origin of Yucca gloriosa: intersectional hybrid speciation in Yucca (Agavoideae, Asparagaceae)
Authors: Rentsch Jeremy D. , Leebens‐Mack Jim 
Published: August 2012

AbstractThere is a growing appreciation for the importance of hybrid speciation in angiosperm evolution. Here, we show that Yucca gloriosa (Asparagaceae: Agavoideae) is the product of intersectional hybridization between Y. aloifolia and Y. filamentosa. These species, all named by Carl Linnaeus, exist in sympatry along the southeastern Atlantic coast of the United States. Yucca gloriosa was found to share a chloroplast haplotype with Y. aloifolia in all populations sampled. In contrast, nuclear gene‐based microsatellite markers in Y. gloriosa are shared with both parents. The hybrid origin of Y. gloriosa is supported by multilocus analyses of the nuclear microsatellite markers including principal coordinates analysis (PCO), maximum‐likelihood hybrid index scoring (HINDEX), and Bayesian cluster analysis (STRUCTURE). The putative parental species share only one allele at a single locus, suggesting there is little to no introgressive gene flow occurring between these species and Y. gloriosa. At the same time, diagnostic markers are segregating in Y. gloriosa populations. Lack of variation in the chloroplast of Y. aloifolia, the putative maternal parent, makes it difficult to rule out multiple hybrid origins of Y. gloriosa, but allelic variation at nuclear loci can be explained by a single hybrid origin of Y. gloriosa. Overall, these data provide strong support for the homoploid hybrid origin of Y. gloriosa.