bluuebunny/crossref_metadata_2025_split huggingface dataset:
La Bajoulière en St-Rémy-la-Varenne (Maine-et-Loire). Fouille et restauration d'un grand "Dolmen Angevin"
Authors: Gruet Michel , Passini Bernard 
Published: December 2011

The dolmen of La Bajoulière stands two kilometers south of the Loire river, between Angers and Saumur. It is an impressive, huge, megalithic, square monument. Its pattern is "angevin" type, that is to say it has a short porch (portique). Before the dolmen has been built, the place had been occupied by an Augy-Ste Pallaye neolithic group. It has been impossible to find out the builders'identity, because gallo-roman and Middle-Ages people had inhabited the burial-chamber.
We observed, inside, a transversal megalithic partition with an axial way. Outside, we made clear remains of a pear shaped cairn, tapering at the back and including a wall dividing it, probably, into two banks, and a two-horned fore-court. One of thèse horns was defaced, may be at the Bronze-Age. It is not quite certain that this fore-court has been made up by the burial-chamber builders.
Le tumulus de Renongar en Plovan (Finistère). Etude d'une fouille ancienne de Paul Du Chatellier
Authors: Polles Ronan 
Published: December 2011

The monument of Renongar at Plovan (Finistère) is a megalithic complex excavated by the finisterian
archaeologist Paul Du Chatellier in the last century but which has not been fully published.
This monument procured an important material includingone of the most important assemblages of Kerugou ware.
One of the orthostats was carved on both sides and the design shows that it may be a decorated menhir re-used as a slab.
From the ceramic material, the author studies the relations between Groh-Collé ware and Kerugou ware in south Finistère.
Le site paléolithique inférieur de Raguénés (Névez, Finistère). Cadre géologique et industrie
Authors: Molines Nathalie , Gageonnet Robert , Monnier Jean Laurent 
Published: December 2011

Une industrie exclusivement en quartz a été découverte sur la commune de Névez (Finistère) en plusieurs points de la falaise bordant la plage et l'îlot de Raguénés. La conservation du gisement pourrait être liée à une ancienne anse colmatée qui se marque dans l 'arrière-côte par une dépression topographique et une petite falaise morte. Le niveau archéologique est associé à des restes de plage ancienne et à un head recouvrant le substratum de micaschistes.
L'homogénéité des pièces taillées, quant à leur état de surface, comme à leurs caractères techno-typologiques, plaide en faveur d'une unique occupation attribuée au Paléolithique inférieur. A titre d'hypothèse et par référence au contexte stratigraphique sud armoricain, un âge correspondant aux stades isotopiques 9 ou 11 est proposé.
Intermittent Peritoneal Dialysis: Urea Kinetic Modeling and Implications of Residual Kidney Function
Authors: Guest Steven , Akonur Alp , Ghaffari Arshia , Sloand James , Leypoldt John K. 
Published: December 2011

♦Background Intermittent peritoneal dialysis (IPD) is an old strategy that has generally been eclipsed, in the home setting, by daily peritoneal therapies. However, for a select group of patients with exhausted vascular access or inability to receive PD at home, in-center IPD may remain an option or may serve as an incremental strategy before initiation of full-dose PD. We investigated the residual kidney clearance requirements necessary to allow thrice-weekly IPD regimens to meet current adequacy targets. ♦Methods The 3-pore model of peritoneal transport was used to examine 2 thrice-weekly IPD dialysis modalities: 5 – 6 dwells with 10 – 12 L total volume (low-dose IPD), and 50% tidal with 20 – 24 L total volume (high-dose IPD). We assumed an 8-hour dialysis duration and 1.5% dextrose solution, with a 2-L fill volume, except in tidal mode. The PD Adequest application (version 2.0: Baxter Healthcare Corporation, Deerfield, IL, USA) and typical patient kinetic parameters derived from a large dataset [data on file from Treatment Adequacy Review for Gaining Enhanced Therapy (Baxter Healthcare Corporation)] were used to model urea clearances. The minimum glomerular filtration rate (GFR) required to achieve a total weekly urea Kt/V of 1.7 was calculated. ♦Results In the absence of any dialysis, the minimum residual GFR necessary to achieve a weekly urea Kt/V of 1.7 was 9.7 mL/min/1.73 m2. Depending on membrane transport type, the low-dose IPD modality met urea clearance targets for patients with a GFR between 6.0 mL/min/1.73 m2 and 7.6 mL/min/1.73 m2. Similarly, the high-dose IPD modality met the urea clearance target for patients with a GFR between 4.7 mL/min/1.73 m2 and 6.5 mL/min/1.73 m2. ♦Conclusions In patients with residual GFR of at least 7.6 mL/min/1.73 m2, thrice-weekly low-dose IPD (10 L) achieved a Kt/V urea of 1.7 across all transport types. Increasing the IPD volume resulted in a decreased residual GFR requirement of 4.7 mL/min/1.73 m2 (24 L, 50% tidal). In patients with residual kidney function and dietary compliance, IPD may be a viable strategy in certain clinical situations.
Les carrières de consommation d'usagers de cocaïne inconnus des institutions socio-sanitaires et répressives une recherche qualitative conduite en France en 2007-2009
Authors: Reynaud-Maurupt Catherine , Maitena Milhet , Hoareau Emmanuelle , Cadet-Taïrou Agnès 
Published: December 2011

Cet article porte sur les carrières d’usagers de cocaïne inconnus des institutions socio-sanitaires et répressives. Il présente les résultats d’une enquête conduite par entretiens semi-directifs auprès de 50 usagers appartenant à cette population cachée. Les auteurs retracent les différentes étapes des carrières en portant une attention particulière aux fréquences d’usage mais aussi aux contextes de consommation, aux significations de l’usage ainsi qu’aux dynamiques de groupe façonnant les parcours individuels.
IDO and Regulatory T Cell Support Are Critical for Cytotoxic T Lymphocyte-Associated Ag-4 Ig-Mediated Long-Term Solid Organ Allograft Survival
Authors: Sucher Robert , Fischler Klaus , Oberhuber Rupert , Kronberger Irmgard , Margreiter Christian , Ollinger Robert , Schneeberger Stefan , Fuchs Dietmar , Werner Ernst R. , Watschinger Katrin , Zelger Bettina , Tellides George , Pilat Nina , Pratschke Johann , Margreiter Raimund , Wekerle Thomas , Brandacher Gerald 
Published: December 2011

AbstractCostimulatory blockade of CD28-B7 interaction with CTLA4Ig is a well-established strategy to induce transplantation tolerance. Although previous in vitro studies suggest that CTLA4Ig upregulates expression of the immunoregulatory enzyme IDO in dendritic cells, the relationship of CTLA4Ig and IDO in in vivo organ transplantation remains unclear. In this study, we studied whether concerted immunomodulation in vivo by CTLA4Ig depends on IDO. C57BL/6 recipients receiving a fully MHC-mismatched BALB/c heart graft treated with CTLA4Ig + donor-specific transfusion showed indefinite graft survival (&gt;100 d) without signs of chronic rejection or donor specific Ab formation. Recipients with long-term surviving grafts had significantly higher systemic IDO activity as compared with rejectors, which markedly correlated with intragraft IDO and Foxp3 levels. IDO inhibition with 1-methyl-dl-tryptophan, either at transplant or at postoperative day 50, abrogated CTLA4Ig + DST-induced long-term graft survival. Importantly, IDO1 knockout recipients experienced acute rejection and graft survival comparable to controls. In addition, αCD25 mAb-mediated depletion of regulatory T cells (Tregs) resulted in decreased IDO activity and again prevented CTLA4Ig + DST induced indefinite graft survival. Our results suggest that CTLA4Ig-induced tolerance to murine cardiac allografts is critically dependent on synergistic cross-linked interplay of IDO and Tregs. These results have important implications for the clinical development of this costimulatory blocker.
Fundamental Characteristics of the Immunoglobulin VH Repertoire of Chickens in Comparison with Those of Humans, Mice, and Camelids
Authors: Wu Leeying , Oficjalska Katarzyna , Lambert Matthew , Fennell Brian J. , Darmanin-Sheehan Alfredo , Ní Shúilleabháin Deirdre , Autin Bénédicte , Cummins Emma , Tchistiakova Lioudmila , Bloom Laird , Paulsen Janet , Gill Davinder , Cunningham Orla , Finlay William J. J. 
Published: December 2011

Abstract
Examination of 1269 unique naive chicken VH sequences showed that the majority of positions in the framework (FW) regions were maintained as germline, with high mutation rates observed in the CDRs. Many FW mutations could be clearly related to the modulation of CDR structure or the VH–VL interface. CDRs 1 and 2 of the VH exhibited frequent mutation in solvent-exposed positions, but conservation of common structural residues also found in human CDRs at the same positions. In comparison with humans and mice, the chicken CDR3 repertoire was skewed toward longer sequences, was dominated by small amino acids (G/S/A/C/T), and had higher cysteine (chicken, 9.4%; human, 1.6%; and mouse, 0.25%) but lower tyrosine content (chicken, 9.2%; human, 16.8%; and mouse 26.4%). A strong correlation (R2 = 0.97) was observed between increasing CDR3 length and higher cysteine content. This suggests that noncanonical disulfides are strongly favored in chickens, potentially increasing CDR stability and complexity in the topology of the combining site. The probable formation of disulfide bonds between CDR3 and CDR1, FW2, or CDR2 was also observed, as described in camelids. All features of the naive repertoire were fully replicated in the target-selected, phage-displayed repertoire. The isolation of a chicken Fab with four noncanonical cysteines in the VH that exhibits 64 nM (KD) binding affinity for its target proved these constituents to be part of the humoral response, not artifacts. This study supports the hypothesis that disulfide bond-constrained CDR3s are a structural diversification strategy in the restricted germline v-gene repertoire of chickens.
Implementing a Dietary Intervention in Primary Care Practice: A Process Evaluation
Authors: Lazovich DeAnn , Curry Susan J. , Beresford Shirley A. A. , Kristal Alan R. , Wagner Edward H. 
Published: December 2011

Objectives. Physicians acknowledge the need to advise their patients about dietary habits, but they may not have the training or tools to do this efficiently. In the context of a randomized trial, we investigated the feasibility of enlisting physicians to implement a dietary intervention in the primary care setting. Methods. Physicians from 14 primary care practices were assigned via randomization to introduce a self-help booklet to promote dietary change at routine appointments. Delivery of the booklet was recorded by these intervention physicians at the clinic appointment; intervention participants were asked 3 months later in a telephone interview about whether they received and used the booklet. Results. According to physician documentation, 95 % of intervention participants who kept an appointment (n = 935) received the booklet; among participants completing a 3-month interview (n = 890), 96% reported the same. However, only about 50% of participants reported receiving the booklet from their physician; the remainder received the booklet from other clinic staff. Overall, 93 % reported reading at least part of the booklet. Use of the booklet varied little whether it was delivered by a physician or staff person, but it was more likely to be read as time spent discussing the booklet increased. Conclusions. Physician cooperation and evidence of intervention effectiveness support the use of primary care for the delivery of interventions to change diet; training the entire health team and repeating dietary advice at subsequent visits may improve the success of such interventions.
Carbon Nanotubes, Multi‐Walled
Authors: Andrews Rodney , Weisenberger Matthew C. , Qian Dali , Meier Mark S. , Cassity Kelby , Yeary Paul E. 
Published: December 2011

AbstractWell‐aligned carbon multiwalled nanotubes (MWNTs) have been synthesized continuously by pyrolysis of xylene–ferrocene mixtures. To study the MWNT growth mechanism, two‐step processes and various chemical vapor deposition (CVD) parameters have been employed. Transmission electron microscopy observations support a tip‐root growth model of MWNTs by floating catalytic CVD. Hydrocarbon analyzer is used to measure the total carbon balance within the CVD reactor, while mass spectra analyses monitor the concentrations of hydrocarbon species, which helps to understand the catalyst deactivation and pyrolysis chemistry of xylene over catalyst Fe(C) nanoparticles. MWNTs can be treated to attach required functional groups on nanotube walls and/or caps for specific applications by various methods including acid oxidation, reduction, addition of radicals, and cycloadditions. Carbon nanotubes (CNTs) have shown promising applications in advanced CNT–polymer composites. To realize CNT potentials to enhance the properties of matrices, several important issues such as dispersion, orientation, interfacial effects, and processing parameters have been addressed. The dependence of the CNT–polymer composite properties on CNT diameter, length, and interfacial effects has been used to develop models to predict and optimize variables for maximum composite performance. CNT–polymer composites have been developed for enhanced mechanical, electrical, and thermal properties, which have wide applications for the next generation of truly multifunctional materials as well as lighter weights and increased manufacturability over current materials.
A dynamic control middleware for cyber physical systems on an IPv6‐based global network
Authors: Park Sang Oh , Do Tae Hoon , Jeong Young‐Sik , Kim Sung Jo 
Published: December 2011

SUMMARYA cyber physical system (CPS) is a deeply embedded system that can be applied to home devices, medical equipment, cars, and so on. Because it is expected that a CPS system will be integrated with other CPSes designed for various areas to ultimately create a global CPS network, IPv6 is suitable for these large‐scale integrated network environments. In addition, it is important to reduce high network load for efficient device control. This paper proposes a dynamic control middleware for an efficient search and control of devices on an IPv6‐based global network from anywhere through smartphones along with a new mechanism intended to drastically reduce the number of messages that are generated for searching devices. We construct an IPv6‐based testbed using laptops and smartphones to demonstrate that this middleware can be adopted by mobile devices for dynamic remote control of home devices. Copyright © 2011 John Wiley & Sons, Ltd.
Segment design under consideration of the material used to fill the annular gap / Tübbingbemessung unter Berücksichtigung der Eigenschaften des Ringspaltmaterials
Authors: Thienert Christian , Pulsfort Matthias 
Published: December 2011

AbstractFor the structural design using the bedding modulus method of the linings of tunnels to be driven by shield machines in granular soil, the surrounding ground is normally discretised with radially arranged extension springs, the stiffness of which is derived from the load‐displacement behaviour of the surrounding ground (stiffness modulus Es). The precondition for this is that the properties of the mortar used to fill the annular gap at least correspond to those of the surrounding soil. If this is not the case – for example, if the grout is softer than a densely bedded non‐cohesive soil – corresponding negative effects on the deformation of the tunnel lining are to be expected. This can even lead to damage to the segments in the form of spalling or leaks. In order to be able to quantify such effects and consider them in future structural calculations, the results of a parameter study using the finite‐element method (FEM) for a tunnel in water‐saturated granular soil are presented and a simply applied, modified bedding approach is proposed on this basis.Bei der Bemessung von Tübbingschalen für im Schildvortrieb aufzufahrende Tunnel im Lockergestein mithilfe des Bettungsmodulverfahrens wird der umgebende Baugrund in einem ebenen Berechnungsausschnitt üblicherweise durch radial angeordnete Dehnfedern diskretisiert, deren Steifigkeit aus dem Last‐Verformungs‐Verhalten des Bodens (Steifemodul Es) abgeleitet wird. Voraussetzung hierfür ist, dass die Eigenschaften des im Zuge der Ringspaltverpressung eingesetzten Mörtelmaterials mindestens jenen des umgebenden Bodens entsprechen. Ist dies nicht der Fall – beispielsweise wenn das Verpressgut weicher als ein dicht gelagerter nicht bindiger Boden ist – sind entsprechende negative Auswirkungen auf die Verformungen des Tunnelausbaus und auf dessen Biegebeanspruchung zu erwarten. Letztlich können hierdurch sogar Tübbingschäden in Form von Abplatzungen und Leckagen begünstigt werden. Um entsprechende Einflüsse bei einer statischen Berechnung zukünftig quantifizieren und berücksichtigen zu können, werden Ergebnisse einer Parameterstudie nach der Methode der Finiten Elemente (FEM) für einen Tunnel in wassergesättigtem Lockergestein vorgestellt und auf deren Grundlage ein einfach handhabbarer, modifizierter Bettungsansatz vorgeschlagen.
The impact of emerging institutional norms on adoption timing decisions: evidence from C‐TPAT—A government antiterrorism initiative
Authors: Ritchie William J. , Melnyk Steven A. 
Published: December 2011

AbstractDrawing upon an institutional theoretic perspective, this study explores the performance outcomes associated with adoption timing and level of investment in a government antiterrorism initiative—the Customs Trade Partnership Against Terrorism (C‐TPAT). Using a large‐scale sample of C‐TPAT certified importers, this study found that performance outcomes for high levels of investment in adoption processes differ depending upon the strength of institutional forces. Specifically, early adopters of C‐TPAT processes in a weak institutional context that reported high levels of investment performed no better than firms who invested nominally in the processes, while late adopters in a strong institutional context that reported high investment levels outperformed those that invested nominally. This finding can be explained by viewing C‐TPAT as an ‘emerging’ institution, where forces are coalescing. Copyright © 2011 John Wiley & Sons, Ltd.
Sequential liver–kidney transplantation in a boy with congenital hepatic fibrosis and nephronophthisis from a living donor
Authors: Udagawa Tomohiro , Kamei Koichi , Ogura Masao , Tsutsumi Akiko , Noda Shunsuke , Kasahara Mureo , Fukuda Akinari , Sakamoto Seisuke , Shigeta Shigenobu , Tanaka Hideaki , Kuroda Tatsuo , Matsuoka Kentarou , Nakazawa Atuko , Nagai Takuto , Uemura Osamu , Ito Shuichi 
Published: December 2011

Udagawa T, Kamei K, Ogura M, Tsutsumi A, Noda S, Kasahara M, Fukuda A, Sakamoto S, Shigeta S, Tanaka H, Kuroda T, Matsuoka K, Nakazawa A, Nagai T, Uemura O, Ito S. Sequential liver–kidney transplantation in a boy with congenital hepatic fibrosis and nephronophthisis from a living donor.  Pediatr Transplantation 2011. © 2011 John Wiley & Sons A/S.Abstract:  A five‐yr‐old boy developed chronic liver failure and ESKD because of CHF and juvenile NPHP. He underwent sequential liver and kidney transplantation with a compatible blood type from his father, at five yr, seven months and five yr, 11 months old, respectively. Because the patient was not in ESKD, we initially performed LDLT because of significant portal hypertension. Even after LDLT, his ascites was not ameliorated, and he needed continuous drainage of ascites and daily albumin and gamma globulin infusion. Thereafter, he progressed to ESKD and needed hemodialysis for one month before LDKT. CDC crossmatch for donor B cells in the warm test, FCXM for B cell IgG, and flow PRA for donor class II were positive before LDKT. After pretreatment of three courses of plasma exchange and intravenous gamma globulin, LDKT was performed. Two weeks after LDKT, AIHA concomitant with autoimmune thrombocytopenia, also called Evans syndrome, occurred because of passenger lymphocytes from the donor; however, the patient was successfully treated with intravenous methylprednisolone. Eighteen months have passed since LDKT, and liver and kidney function in both the recipient and donor are normal.
Why Governments Should Use the Government Finance Statistics Accounting System
Authors: BARTON ALLAN 
Published: December 2011

In May 2008, the Australian government presented its budget to parliament solely in terms of the IMF Government Finance Statistics (GFS) accounting system; and in December 2008 it announced that all outcome financial statements were also to be GFS based.These two decisions brought to an end a long and arduous controversy over the use of accrual accounting by governments in Australia since their adoption the early 1990s. Initially, the Australian Accounting Standards (AAS) business‐based system was adopted, with a few modest extensions covering the public sector. However, there was much controversy over the displacement of cash accounting and budgeting systems by accrual accounting; and secondly whether the AAS system was appropriate for the public sector.In May 1999, the Australian government introduced accrual budgeting in place of cash budgets. However two sets of accrual budgets were presented to parliament—an AAS‐based one and a GFS‐based one. The two budgets presented substantially different results, causing endless confusion in parliament. Furthermore, departments and the whole of government continued to present only AAS outcome financial statements.In this paper, the above history is traced out together with the reasons for the decisions. The final decision to adopt the GFS system, covering both cash and accrual accounting systems, is explained in terms of the roles and operating environments of governments. These determine the financial information needs of government, and they are shown to be fundamentally different from those of business. Finally, the structure and concepts used in the GFS system are explained.
Implementation of a pediatric trauma massive transfusion protocol: one institution's experience
Authors: Hendrickson Jeanne E. , Shaz Beth H. , Pereira Greg , Parker Paul M. , Jessup Paula , Atwell Falisha , Polstra Beth , Atkins Elizabeth , Johnson Karen K. , Bao Gaobin , Easley Kirk A. , Josephson Cassandra D. 
Published: December 2011

BACKGROUND: Massive transfusion protocols (MTPs) with fixed ratios of blood products may improve outcomes in coagulopathic adult trauma patients. However, there is a paucity of data on transfusion support protocols for pediatric trauma patients, whose mechanisms of injury may differ from those seen in adults. We hypothesized that an MTP would improve outcomes in children, through a balanced blood product resuscitation.STUDY DESIGN AND METHODS: A pediatric trauma MTP, with a fixed ratio of red blood cells (RBCs) : fresh‐frozen plasma (FFP) : platelets : cryoprecipitate in quantities based on the patient's weight, was initiated at a pediatric hospital. Data on clinical status, resuscitation volumes, and hospital course were collected and compared to data from pre‐MTP trauma patients requiring transfusion.RESULTS: Fifty‐three patients were enrolled over a 15‐month period and compared to 49 pre‐MTP patients. Seventy‐two percent of MTP patients had at least one coagulation value outside of the normal range upon emergency department (ED) arrival, and the median time to FFP transfusion decreased fourfold after MTP implementation (p < 0.0001). A total of 49% of MTP patients received greater than 70 mL/kg blood products, and the 24‐hour median FFP : RBC transfusion ratio was twofold higher in these patients than the pre‐MTP cohort (median, 1:1.8 vs. 1:3.6; p = 0.002). No improvement in mortality was observed after MTP implementation, taking into consideration injury severity, prothrombin time, and partial thromboplastin time.CONCLUSIONS: A pediatric trauma MTP is feasible and allows for rapid provision of balanced blood products for transfusion to coagulopathic children. Larger studies are warranted to determine whether such protocols will improve outcomes for pediatric trauma patients.