bluuebunny/crossref_metadata_2025_split huggingface dataset:
Beyond the Passive Diffusion: Core@Satellite Magneto‐Plasmonic Particles for Rapid and Sensitive Colorimetric Immunosensor Response
Authors: De Luca Maria , Acunzo Adriano , Marra Daniele , Borriello Margherita , Ingrosso Diego , Velotta Raffaele , Iannotti Vincenzo , Della Ventura Bartolomeo 
Published: June 2024

AbstractMagneto‐plasmonic particles, comprising gold and iron oxide, exhibit substantial potential for biosensing applications due to their distinct properties. Gold nanoparticles (AuNPs) provide plasmonic features, while iron oxide composites, responsive to an external magnetic field, significantly reduce detection time compared to passive diffusion. This study explores core@satellite magneto‐plasmonic particles (CSMPs), featuring magnetic nanoparticle clusters and numerous satellite‐like AuNPs, to amplify the optical response on a nanostructured gold surface. Using a sandwich scheme, target analytes are detected as hybrid nanoparticles bind to the pre‐immobilized target on the AuNPs surface, inducing changes in the immunosensor's extinction spectrum. Application of an external magnetic field notably enhances biosensor response and sensitivity, reducing assay time from hours to minutes. Leveraging the properties of CSMPs, the immunosensor detects specific immune protein at low concentrations within minutes. CSMPs hold considerable promise for precise and sensitive analyte detection, offering potential applications in rapid testing and mass screening.
Strong Acid Enabled Comprehensive Training of Poly (Sodium Acrylate) Hydrogel Networks
Authors: Yang Baibin , Wang Caihong , Yu Qiannan , Ma Peipei , Zhao Qiang , Wu Yong , Ma Kui , Tan Shuai 
Published: June 2024

AbstractThe design of admirable hydrogel networks is of both practical and fundamental importance for diverse applications of hydrogels. Herein a general strategy of acid‐assisted training is designed to enable multiple improvements of conventional poly (sodium acrylate) networks for hydrogels. Hydrophobic homogeneous crosslinked poly (sodium acrylate) hydrogels are prepared to verify the strategy. The multiple improvements of poly (sodium acrylate) networks are simply achieved by immersing the hydrogel networks into 4 M H2SO4 solutions. The introduced acids would induce transformation of poly (sodium acrylate) into poly (acrylic acid) at hydrogel surface, which constructs dynamic hydrogen bonding interactions to tighten the network. The acid‐containing poly (sodium acrylate) hydrogels newly generate anti‐swelling and self‐healing performance, and show mechanical improvement. The internal poly (sodium acrylate) of the pristine acid‐containing hydrogels is further fully transformed via acid‐infiltration after following cyclic stretch/release training to significantly improve the mechanical performance. The Young's modulus, stress, and toughness of the fully‐trained hydrogels are 187.6 times, 35.6 times, and 5.4 times enhanced, respectively. The polymeric networks retain isotropic in fully‐trained hydrogels to ensure superior stretchability of 8.6. The acid‐assisted training performance of the hydrogels can be reversibly recovered by NaOH neutralization. The acid‐assisted training strategy here is general for poly (sodium acrylate) hydrogels.
Exploration of the sensitization effect of Chaihu Shugan powder on chemotherapy for triple‐negative breast cancer and its active ingredients
Authors: Wei Wei , Li Xiaofei , Li Zhiyuan 
Published: June 2024

AbstractChemotherapy plays a crucial role in the clinical treatment of triple‐negative breast cancer (TNBC), but drug resistance limits its clinical application. The active ingredients of Chaihu Shugan Powder (CSP; Bupleurum Liver‐Coursing Powder), quercetin and luteolin, both belong to flavonoid compounds and have significant anti‐tumor potential, which can promote chemotherapy sensitivity. However, the correlation between the two and TNBC paclitaxel (PTX) chemotherapy sensitivity is unknown. We collected herbal components of CSP from the TCMSP database, and screened effective molecules and corresponding targets. STRING database was utilized to construct a protein–protein interaction network combining effective molecules and target genes. The top 50 nodes ranked by affinity were chosen for subsequent functional analysis, and the drug‐active ingredient‐gene interaction network was established using Cytoscape software. Molecular docking was used to determine the small molecules that target TNBC PTX resistance. The “clusterProfiler” package was utilized for GO and KEGG enrichment analyses on the top 50 genes to determine the pathways affected by CSP. Cell counting and colony formation assays evaluated cell viability, IC50 values, and proliferation capacity. Flow cytometry tested PTX intracellular accumulation. Western blot assayed the expression of TNF pathway‐related proteins. Active ingredients of CSP, quercetin and luteolin, could inhibit TNBC cell proliferation and promote PTX chemotherapy sensitization. Quercetin and luteolin repressed the TNF signaling pathway and promoted PTX chemotherapy sensitization. Quercetin and luteolin could inhibit TNBC cell proliferation and promote PTX chemotherapy sensitization through the TNF signaling pathway. Therefore, the use of quercetin and luteolin plus PTX treatment provides a prospective strategy for TNBC treatment.
A clinical‐radiomic‐pathomic model for prognosis prediction in patients with hepatocellular carcinoma after radical resection
Authors: Xie Qu , Zhao Zeyin , Yang Yanzhen , Wang Xiaohong , Wu Wei , Jiang Haitao , Hao Weiyuan , Peng Ruizi , Luo Cong 
Published: June 2024

AbstractPurposeRadical surgery, the first‐line treatment for patients with hepatocellular cancer (HCC), faces the dilemma of high early recurrence rates and the inability to predict effectively. We aim to develop and validate a multimodal model combining clinical, radiomics, and pathomics features to predict the risk of early recurrence.Materials and MethodsWe recruited HCC patients who underwent radical surgery and collected their preoperative clinical information, enhanced computed tomography (CT) images, and whole slide images (WSI) of hematoxylin and eosin (H & E) stained biopsy sections. After feature screening analysis, independent clinical, radiomics, and pathomics features closely associated with early recurrence were identified. Next, we built 16 models using four combination data composed of three type features, four machine learning algorithms, and 5‐fold cross‐validation to assess the performance and predictive power of the comparative models.ResultsBetween January 2016 and December 2020, we recruited 107 HCC patients, of whom 45.8% (49/107) experienced early recurrence. After analysis, we identified two clinical features, two radiomics features, and three pathomics features associated with early recurrence. Multimodal machine learning models showed better predictive performance than bimodal models. Moreover, the SVM algorithm showed the best prediction results among the multimodal models. The average area under the curve (AUC), accuracy (ACC), sensitivity, and specificity were 0.863, 0.784, 0.731, and 0.826, respectively. Finally, we constructed a comprehensive nomogram using clinical features, a radiomics score and a pathomics score to provide a reference for predicting the risk of early recurrence.ConclusionsThe multimodal models can be used as a primary tool for oncologists to predict the risk of early recurrence after radical HCC surgery, which will help optimize and personalize treatment strategies.
Happiness contagion in China's cities: Who gets more happiness from urban communities?
Authors: Yang Chang , Zhang Zhe , Sha Chenbing 
Published: June 2024

AbstractWhile emotional transmission is a well‐documented phenomenon, the contagion of happiness, specifically as a positive emotion, has received limited research attention. This study utilizes data from the 2015 Chinese General Social Survey (CGSS2015) to analyse the effects of happiness contagion among different individual groups in urban communities. Findings indicate that individuals with positive personalities and social attitudes are more susceptible to happiness contagion. Regarding personal and job attributes, the elderly, the highly educated, the married, or people who are religious, have high incomes, work in non‐state‐owned enterprises, or work flexibly tend to receive more happiness from their neighbours. Moreover, residents living in economically developed areas exhibit a greater receptivity to happiness contagion. The paper discusses policy implications of the results. Please refer to the Supplementary Material section to find this article's Community and Social Impact Statement.
Effects of metformin on cancers in experimental and clinical studies: Focusing on autophagy and AMPK/mTOR signaling pathways
Authors: Zamanian Mohammad Yasin , Golmohammadi Maryam , Yumashev Alexey , Hjazi Ahmed , Toama Mariam Alaa , AbdRabou Mervat Ahmed , Gehlot Anita , Alwaily Enas R. , Shirsalimi Niyousha , Yadav Pankaj Kumar , Moriasi Gervason 
Published: June 2024

AbstractMetformin (MET) is a preferred drug for the treatment of type 2 diabetes mellitus. Recent studies show that apart from its blood glucose‐lowering effects, it also inhibits the development of various tumours, by inducing autophagy. Various studies have confirmed the inhibitory effects of MET on cancer cell lines’ propagation, migration, and invasion. The objective of the study was to comprehensively review the potential of MET as an anticancer agent, particularly focusing on its ability to induce autophagy and inhibit the development and progression of various tumors. The study aimed to explore the inhibitory effects of MET on cancer cell proliferation, migration, and invasion, and its impact on key signaling pathways such as adenosine monophosphate‐activated protein kinase (AMPK), mammalian target of rapamycin (mTOR), and PI3K. This review noted that MET exerts its anticancer effects by regulating key signalling pathways such as phosphoinositide 3‐kinase (PI3K), LC3‐I and LC3‐II, Beclin‐1, p53, and the autophagy‐related gene (ATG), inhibiting the mTOR protein, downregulating the expression of p62/SQSTM1, and blockage of the cell cycle at the G0/G1. Moreover, MET can stimulate autophagy through pathways associated with the 5′ AMPK, thereby inhibiting he development and progression of various human cancers, including hepatocellular carcinoma, prostate cancer, pancreatic cancer, osteosarcoma, myeloma, and non‐small cell lung cancer. In summary, this detailed review provides a framework for further investigations that may appraise the autophagy‐induced anticancer potential of MET and its repurposing for cancer treatment.
Applying nitrogen fertilizer improves the indica rice (Oryza sativa L.) quality by coordinating enzyme activity and grain‐filling rate
Authors: Liu Aihua , Li Yuwei , Yang Liubin , Zhang Yangyang , Liao Shipeng , Li Xiaokun 
Published: June 2024

AbstractBackground and ObjectivesThe effects of nitrogen (N) fertilization on rice quality, grain‐filling rate, and starch synthase activity have been widely studied, but whether there is a relationship between grain‐filling rate and starch synthase activity has not been reported. We conducted a 2‐year field experiment using the indica rice cultivar Shenliangyou 5814 to investigate the effects of N fertilization (0, 90, 180, 270, and 360 kg·ha–1) on rice quality.FindingsN fertilization notably increased grain yield, head rice rate, and protein content while reducing chalkiness degree and rate, thereby enhancing milling, appearance, and nutritional quality. Meanwhile, N fertilizer application (N = 270–360 kg·ha–1) delayed the time to reach the maximal grain‐filling rate, extending it to approximately 18.4–19.9 days after flowering, and enzyme activity also peaked around the same time. Grain‐filling rate was positively correlated with the activities of AGPase and SBE after N fertilization. They were also significantly correlated with milling, appearance, and nutritional quality after 22 days of flowering.ConclusionsN fertilization achieved a harmonious balance between the grain‐filling rate and starch synthase activities, ultimately improving milling, appearance, and nutritional quality.Significance and NoveltyN fertilization regulated the coordination between grain‐filling rate and starch synthase activity for rice quality.
Designing Heterogeneous Catalysts for Microwave Assisted Selective Oxygenation
Authors: Sun Jia , Hayward James S. , Barter Michael , Slocombe Daniel R. , Bartley Jonathan K. 
Published: June 2024

AbstractMicrowave dielectric heating is an emerging technology in heterogeneous catalysis. However, catalyst design in this field is not as well developed as when conventional heating is used. In this study the selective oxidation of propene to acrolein has been used as a model reaction to understand the how the properties of bismuth mixed metal oxide catalysts can be tuned for use in microwave assisted catalysis. The role of the dielectric properties, that are crucial to enable the catalyst to be heated in the microwave electric field, were determined using cavity perturbation methods. Catalysts with a very high loss tangent reached high temperatures leading to combustion products, whereas materials with a low loss tangent could not be heated and were inactive. Bi2MoO6 and BiVO4 both showed promising performance during an initial screening and were investigated further. For Bi2MoO6, a partial substitution of molybdenum with vanadium resulted in the formation of Bi1−X/3V1−xMoxO4, with a decrease in particle size and dielectric loss tangent, and the highest rate of acrolein production was found when x=0.6 at 15 W microwave power. Higher microwave power resulted in thermal runaway which decreased the activity of the catalyst.
Synthesis and Application of Robust Spiro [Fluorene‐9] CAAC Ruthenium Alkylidene Complexes for the “One‐Pot” Conversion of Allyl Acetate to Butane‐1,4‐diol
Authors: Erdélyi Ádám , Farkas Vajk , Turczel Gábor , Nagyházi Márton , Bényei Attila , Recta Merell Lystra Ledesma , Nagy Tibor , Kéki Sándor , Osterthun Ole , Klankermayer Jürgen , Tuba Róbert 
Published: June 2024

AbstractA series of a novel CAAC ligands featuring a spiro‐fluorene group have been synthesized and complexed with ruthenium alkylidenes, yielding the corresponding Hoveyda‐type derivatives as a new family of olefin metathesis catalysts. The novel complexes have been characterized by XRD, HRMS and NMR measurements. The synthetised complexes were tested in catalysis and showed good activity in olefin metathesis, as demonstrated on diethyl diallylmalonate and allyl acetate substrates. The unique backbone in the ligand with the large, yet inflexible condensed system renders interesting properties to the catalyst, exemplified by the good catalytic performance and improved Z‐selectivity. In addition, the complex can also serve as a hydrogenation catalyst in a consecutive (one‐pot) reaction. The latter reaction can convert allyl acetate to butane‐1,4‐diol, a valuable chemical intermediate for biodegradable polybutylene succinate (PBS).
Ring Rearrangement Reactions of 4‐Alkenylisocoumarins and Photophysical Evaluation of Multi‐Substituted Anthracene Products
Authors: Kawazoe Teru , Yanai Hikaru , Fukuhara Toya , Kanatani Yusaku , Imakhlaf Amanda , Witulski Bernhard , Matsumoto Takashi 
Published: June 2024

AbstractHerein we report that readily available 4‐alkenylisocoumarins can be regarded as potent dienolate equivalents. For example, lactol silyl ethers derived from 4‐alkenylisocoumarins were selectively converted to the corresponding benzo‐homophthalates through a fluoride‐induced ring opening step that was followed by a ring closure through a vinylogous intramolecular aldol condensation. Likewise, nucleophilic activation of 4‐alkenylisocoumarins directly yields diversely poly‐substituted naphthalenes and anthracenes without formation of any regioisomer. Photophysical evaluation of a set of thus obtained 1,3‐di‐ and 1,3,4‐trisubstituted anthracenes reveals their distinct intramolecular charge transfer (ICT) character during light absorption in polar solutions and excimer emission from the solid state when a face‐to‐face π‐stacked molecular assembly is present in the crystal packing.
Direct Inhibition of the YAP : TEAD Interaction: An Unprecedented Drug Discovery Challenge
Authors: Chène Patrick 
Published: June 2024

AbstractThe Hippo pathway, which is key in organ morphogenesis, is frequently deregulated in cancer. The TEAD (TEA domain family member) transcription factors are the most distal elements of this pathway, and their activity is regulated by proteins such as YAP (Yes‐associated protein). The identification of inhibitors of the YAP : TEAD interaction is one approach to develop novel anticancer drugs: the first clinical candidate (IAG933) preventing the association between these two proteins by direct competition has just been reported. The discovery of this molecule was particularly challenging because the interface between these two proteins is large (~3500 Å2 buried in complex formation) and made up of distinct contact areas. The most critical of these involves an omega‐loop (Ω‐loop), a secondary structure element rarely found in protein‐protein interactions. This review summarizes how the knowledge gained from structure‐function studies of the interaction between the Ω‐loop of YAP and TEAD was used to devise the strategy to identify potent low‐molecular weight compounds that show a pronounced anti‐tumor effect.
Intrinsic capacity and survival among older adults with gastrointestinal malignancies: The Cancer and Aging Resilience Evaluation registry
Authors: Maheshwari Supriya , Dai Chen , Giri Smith , Harmon Christian , Tucker Abigail , Fowler Mackenzie E. , Outlaw Darryl , Williams Grant R. 
Published: June 2024

AbstractBackgroundIntrinsic capacity (IC) was introduced by the World Health Organization (WHO) as a marker of healthy aging, and is defined as the combination of an individual’s physical, mental, and psychological capacities. This study aimed to assess IC via a patient‐reported geriatric assessment (GA) and evaluate its association with survival among older adults with gastrointestinal (GI) malignancies.MethodsData were used from a single‐institution prospective registry of older adults undergoing GA before cancer therapy. Key domains of IC (vitality, locomotion, and sensory [hearing and visual], psychological, and cognitive capacities) were captured via GA, and each was given a score of 0 or 1 (0, impaired) to compute the total IC score (range, 0–6, where 6 indicates no impairment and ≤5 indicates impairment in ≥1 domains). A frailty index (FI) was measured via the deficit accumulation method. Cox regression models and Kaplan–Meier curves were used to examine the impact of IC impairment on survival.ResultsThe study included 665 patients; the median age was 68 years, 57.4% were men, and 72.9% were White. The median IC score was 4, and 79.3% of participants showed impairment in ≥1 domains of IC. Most commonly impaired domains were locomotion (48.7%) and vitality (43.9%). IC was inversely associated with FI (Spearman coefficient, −0.75; p < .001). IC impairment was associated with inferior overall survival (score, 4–5: adjusted hazard ratio [aHR], 1.7; 95% CI, 1.11–2.48; score, 2–3: aHR, 1.9; 95% CI, 1.30–2.85; score, 0–1: aHR, 1.9; 95% CI, 1.11–2.48).ConclusionsIC impairment is associated with frailty and reduced overall survival in older patients with GI malignancies. GA can be used to screen for IC impairment as recommended by the WHO.Plain Language Summary

The World Health Organization introduced intrinsic capacity as a marker of healthy aging.
Intrinsic capacity is the combination of an individual’s physical, mental, and psychological capacities. It contains six key domains: vitality, locomotion, and sensory (hearing and visual), psychological, and cognitive capacities.
Older adults with cancer are susceptible to a decrease in intrinsic capacity as a result of cancer and the aging process.
In this study, we aimed to assess the intrinsic capacity for patients with gastrointestinal cancer and also identify whether there exists any association of intrinsic capacity with overall survival. We identified that approximately 80% of this population had one or more impaired domains, and more intrinsic capacity impairment was associated with reduced overall survival.
Recycling of iron and steel slag for carbon reduction and low‐environment load application
Authors: Xu Ying , Li Enshuo , Hu Chenguang , Zhang Fucheng , Meng Xianguang 
Published: June 2024

AbstractThe high‐value utilization of blast furnace slag (BFS) and steel slag (SS) as a valuable resource in the field of carbon reduction represents a green revolution, and also is an indispensable path toward breaking through resource and environmental constraints and achieving high‐quality, sustainable development through solid waste utilization in the steel industry. Achieving resource recycling while harnessing the untapped latent energy of resources and exploring their carbon sequestration capabilities has become a crucial avenue for further valorization through waste utilization. BFS and SS discharged from iron‐making or steel‐making furnaces carry a significant amount of latent heat, especially the calcium oxide component in SS, which gives it a unique advantage in the field of comprehensive BFS and SS utilization and carbonation‐based SS utilization. This article discusses the current research status of low‐carbon‐waste‐heat utilization in the production of microcrystalline glass, cementitious materials, functional adsorbents, and other products through front‐end modification of molten BFS and SS. This report also provides an overview of carbon capture by utilizing BFS and SS, offering insights into the research directions for subsequent heat recovery, online quality adjustment, high‐value utilization, and carbon sequestration using BFS and SS in the steel industry.