bluuebunny/crossref_metadata_2025_split huggingface dataset:
Auditory motion direction encoding in auditory cortex and high‐level visual cortex
Authors: Alink Arjen , Euler Felix , Kriegeskorte Nikolaus , Singer Wolf , Kohler Axel 
Published: June 2011

AbstractThe aim of this functional magnetic resonance imaging (fMRI) study was to identify human brain areas that are sensitive to the direction of auditory motion. Such directional sensitivity was assessed in a hypothesis‐free manner by analyzing fMRI response patterns across the entire brain volume using a spherical‐searchlight approach. In addition, we assessed directional sensitivity in three predefined brain areas that have been associated with auditory motion perception in previous neuroimaging studies. These were the primary auditory cortex, the planum temporale and the visual motion complex (hMT/V5+). Our whole‐brain analysis revealed that the direction of sound‐source movement could be decoded from fMRI response patterns in the right auditory cortex and in a high‐level visual area located in the right lateral occipital cortex. Our region‐of‐interest‐based analysis showed that the decoding of the direction of auditory motion was most reliable with activation patterns of the left and right planum temporale. Auditory motion direction could not be decoded from activation patterns in hMT/V5+. These findings provide further evidence for the planum temporale playing a central role in supporting auditory motion perception. In addition, our findings suggest a cross‐modal transfer of directional information to high‐level visual cortex in healthy humans. Hum Brain Mapp, 2012. © 2011 Wiley Periodicals, Inc.
Brain structure anomalies in autism spectrum disorder—a meta‐analysis of VBM studies using anatomic likelihood estimation
Authors: Nickl‐Jockschat Thomas , Habel Ute , Maria Michel Tanja , Manning Janessa , Laird Angela R. , Fox Peter T. , Schneider Frank , Eickhoff Simon B. 
Published: June 2011

AbstractAutism spectrum disorders (ASD) are pervasive developmental disorders with characteristic core symptoms such as impairments in social interaction, deviance in communication, repetitive and stereotyped behavior, and impaired motor skills. Anomalies of brain structure have repeatedly been hypothesized to play a major role in the etiopathogenesis of the disorder. Our objective was to perform unbiased meta‐analysis on brain structure changes as reported in the current ASD literature. We thus conducted a comprehensive search for morphometric studies by Pubmed query and literature review. We used a revised version of the activation likelihood estimation (ALE) approach for coordinate‐based meta‐analysis of neuroimaging results. Probabilistic cytoarchitectonic maps were applied to compare the localization of the obtained significant effects to histological areas. Each of the significant ALE clusters was analyzed separately for age effects on gray and white matter density changes. We found six significant clusters of convergence indicating disturbances in the brain structure of ASD patients, including the lateral occipital lobe, the pericentral region, the medial temporal lobe, the basal ganglia, and proximate to the right parietal operculum. Our study provides the first quantitative summary of brain structure changes reported in literature on autism spectrum disorders. In contrast to the rather small sample sizes of the original studies, our meta‐analysis encompasses data of 277 ASD patients and 303 healthy controls. This unbiased summary provided evidence for consistent structural abnormalities in spite of heterogeneous diagnostic criteria and voxel‐based morphometry (VBM) methodology, but also hinted at a dependency of VBM findings on the age of the patients. Hum Brain Mapp, 2011. © 2011 Wiley‐Liss, Inc.
Multivariable analysis of risk factors for enlargement of the tracheoesophageal puncture after total laryngectomy
Authors: Hutcheson Katherine A. , Lewin Jan S. , Sturgis Erich M. , Risser Jan 
Published: June 2011

AbstractBackgroundEnlarged tracheoesophageal puncture (TEP) is a challenging complication of surgical prosthetic voice restoration. Prevention of this complication requires identification of high‐risk individuals, and surgical and prosthetic correlates of TEP enlargement.MethodsMultivariable logistic regression methods were used to analyze preoperative, perioperative, and postoperative risk factors for enlarged TEP in a 5‐year retrospective cohort.ResultsEnlarged TEP only occurred in irradiated patients. Adjusting for length of follow‐up and timing of TEP, advanced (N2 or N3) nodal disease (odds ratio [OR]adjusted, 4.3; 95% confidence interval [CI], 1.0–19.1), postoperative stricture (ORadjusted, 3.2; 95% CI, 1.2–8.6), and diagnosis of locoregional recurrence or distant metastasis after laryngectomy (ORadjusted, 6.2; 95% CI, 2.3–16.4) increased risk of enlarged TEP. Extended resection and preoperative nutritional status were also significantly associated with enlarged TEP. Prosthetic parameters did not significantly correlate with enlargement.ConclusionDevelopment of enlarged TEP is a multifactorial process related to both baseline and postoperative factors. © 2011 Wiley Periodicals, Inc. Head Neck, 2012
Genetic variants in DNA repair genes and the risk of cutaneous malignant melanoma in melanoma‐prone families with/without CDKN2A mutations
Authors: Liang Xueying Sharon , Pfeiffer Ruth M. , Wheeler William , Maeder Dennis , Burdette Laurie , Yeager Meredith , Chanock Stephen , Tucker Margaret A. , Goldstein Alisa M. , Yang Xiaohong R. 
Published: June 2011

AbstractCutaneous malignant melanoma (CMM) is an etiologically heterogeneous disease with genetic, environmental (sun exposure) and host (pigmentation/nevi) factors and their interactions contributing to risk. Genetic variants in DNA repair genes may be particularly important since their altered function in response to sun exposure‐related DNA damage maybe related to risk for CMM. However, systematic evaluations of genetic variants in DNA repair genes are limited, particularly in high‐risk families. We comprehensively analyzed DNA repair gene polymorphisms and CMM risk in melanoma‐prone families with/without CDKN2A mutations. A total of 586 individuals (183 CMM) from 53 families (23 CDKN2A (+), 30 CDKN2A (−)) were genotyped for 2964 tagSNPs in 131 DNA repair genes. Conditional logistic regression, conditioning on families, was used to estimate trend p‐values, odds ratios and 95% confidence intervals for the association between CMM and each SNP separately, adjusted for age and sex. p‐Values for SNPs in the same gene were combined to yield gene specific p‐values. Two genes, POLN and PRKDC, were significantly associated with melanoma after Bonferroni correction for multiple testing (p = 0.0003 and 0.00035, respectively). DCLRE1B showed suggestive association (p = 0.0006). 28 ∼ 56% of genotyped SNPs in these genes had single SNP p < 0.05. The most significant SNPs in POLN and PRKDC had similar effects in CDKN2A (+) and CDKN2A (−) families. Our finding suggests that polymorphisms in DNA repair genes, POLN and PRKDC, were associated with increased melanoma risk in melanoma families with and without CDKN2A mutations.
An American founder mutation in MLH1
Authors: Tomsic Jerneja , Liyanarachchi Sandya , Hampel Heather , Morak Monika , Thomas Brittany C. , Raymond Victoria M. , Chittenden Anu , Schackert Hans K. , Gruber Stephen B. , Syngal Sapna , Viel Alessandra , Holinski‐Feder Elke , Thibodeau Stephen N. , de la Chapelle Albert 
Published: June 2011

AbstractMutations in the mismatch repair genes cause Lynch syndrome (LS), conferring high risk of colorectal, endometrial and some other cancers. After the same splice site mutation in the MLH1 gene (c.589‐2A>G) had been observed in four ostensibly unrelated American families with typical LS cancers, its occurrence in comprehensive series of LS cases (Mayo Clinic, Germany and Italy) was determined. It occurred in 10 out of 995 LS mutation carriers (1.0%) diagnosed in the Mayo Clinic diagnostic laboratory. It did not occur among 1,803 cases tested for MLH1 mutations by the German HNPCC consortium, while it occurred in three probands and an additional five family members diagnosed in Italy. In the U.S., the splice site mutation occurs on a large (∼4.8 Mb) shared haplotype that also harbors the variant c.2146G>A, which predicts a missense change in codon 716 referred to here as V716M. In Italy, it occurs on a different, shorter shared haplotype (∼2.2 Mb) that does not carry V716M. The V716M variant was found to be present by itself in the U.S., German and Italian populations with individuals sharing a common haplotype of 280 kb, allowing us to calculate that the variant arose around 5,600 years ago (225 generations; 95% confidence interval 183–272). The splice site mutation in America arose or was introduced some 450 years ago (18 generations; 95% confidence interval 14–23); it accounts for 1.0% all LS in the Unites States and can be readily screened for.
Adjuvant and neoadjuvant imatinib therapy: Current role in the management of gastrointestinal stromal tumors
Authors: Eisenberg Burton L. , Trent Jonathan C. 
Published: June 2011

AbstractAlthough surgery remains the mainstay for the treatment of primary gastrointestinal stromal tumors (GIST), a significant number of patients experience disease recurrence within 5 years of surgery. The emergence of imatinib therapy for the treatment of patients with advanced GIST has offered unprecedented improvements in clinical outcomes for these patients. Prospective clinical trials have supported the efficacy and safety of imatinib before and after surgical resection of GIST. The American College of Surgeons Oncology Group Z9001 pivotal trial revealed that 1 year of adjuvant imatinib therapy provides significantly superior recurrence‐free survival in patients with GIST after surgical resection, when compared to placebo. Additional trials and case studies have also begun to define the potential clinical benefit of imatinib in the neoadjuvant setting. Optimized risk stratification paradigms will be required to ensure the appropriate selection of patients to undergo treatment with imatinib in these settings. Risk stratification schemes are evolving that potentially will include mutation status and tumor rupture, and predictive nomograms have recently been proposed. The recent European Society of Medical Oncology and National Comprehensive Cancer Network guidelines mention use of adjuvant imatinib for ≥1 year in patients with KIT+, resectable GIST at high risk of recurrence. Moreover, the guidelines support the use of neoadjuvant imatinib in cases of limited disease if it would facilitate less extensive surgery and organ sparing. This article reviews pivotal efficacy and safety data for adjuvant imatinib and explores the potential clinical benefit of neoadjuvant imatinib in patients with GIST.
B7‐H3 contributes to the metastatic capacity of melanoma cells by modulation of known metastasis‐associated genes
Authors: Tekle Christina , Nygren Marit Kveine , Chen Yih‐Wen , Dybsjord Indrejit , Nesland Jahn Marthin , Mælandsmo Gunhild Mari , Fodstad Øystein 
Published: June 2011

AbstractB7‐H3, an immunoregulatory protein, is known to play a role in tumor progression. In many cancer types, observed correlations between high B7‐H3 expression and poor prognosis have been attributed to involvement in antitumor immunity. However, here we demonstrate a nonimmunological alternative function of B7‐H3 in cancer metastasis. Since advanced malignant melanoma is a disease with a poor survival rate and a broad pattern of metastasis, we used this disease as a model in our studies. We found that shRNA silencing of B7‐H3 reduced the in vitro migratory potential and matrigel invasiveness of MDA‐MB‐435 and FEMX‐I melanoma cells. In an experimental metastasis model in vivo, B7‐H3 silencing of MDA‐MB‐435 cells resulted in reduced metastatic capacity and significantly increased the median symptom‐free survival of nude mice (147 vs. 65 days, p < 0.001) and rats (53 vs. 42 days, p = 0.025) injected with MDA‐MB‐435 cells. Furthermore, a smaller fraction of mice had microscopically detectable metastases compared to control animals, and the pattern of metastases was slightly different between the two groups but with the brain as the predominant organ. Immunohistochemistry on samples from two melanoma patients showed strong B7‐H3 staining in both a primary tumor and metastases. Notably, the metastasis‐associated proteins, matrix metalloproteinase (MMP)‐2, signal transducer and activator of transcription 3 (Stat3), and the level of secreted interleukin‐8 (IL‐8) were reduced in the B7‐H3 knock‐down cell variants, whereas tissue inhibitor of metalloproteinase (TIMP)‐1 and‐2 levels were increased. Taken together, our findings indicate a novel role for B7‐H3 in the regulation of the metastatic capacity of melanoma cells and it might be a potential therapeutic target for anti‐metastasis therapy.
Novel senescence associated gene, YPEL3, is repressed by estrogen in ER+ mammary tumor cells and required for tamoxifen‐induced cellular senescence
Authors: Tuttle Rebecca , Miller Kelly R. , Maiorano J. Nicholas , Termuhlen Paula M. , Gao Yongping , Berberich Steven J. 
Published: June 2011

AbstractEstrogen signaling plays an important role in breast carcinogenesis. An increased understanding of estrogen gene targets and their effects will allow for more directed and effective therapies for individuals with breast cancer, particularly those with estrogen receptor positive tumors resistant to tamoxifen therapy. Here, we identify YPEL3 as a growth suppressive protein downregulated by estrogen in estrogen receptor positive breast cancer cell lines. Estrogen repression of YPEL3 expression was found to be independent of p53 but dependent on estrogen receptor alpha expression. Importantly, YPEL3 expression, which is induced by the removal of estrogen or treatment with tamoxifen triggers cellular senescence in MCF‐7 cells while loss of YPEL3 increases the growth rate of MCF‐7 cells. Taken together these findings suggest that YPEL3 may represent a potential target for directed hormonal therapy for estrogen receptor positive breast cancer patients.
Psychology and my gallbladder: an insider's account
Authors: Hoyt Michael F. 
Published: June 2011

AbstractThe subjective experience of the psychologist‐author when addressing and undergoing a surgical procedure is described, including—consistent with his own theoretical and technical orientation‐—the use of various brief therapy and hypnotherapy methods. A narrative of events is presented with interspersed comments about internal processes and reflections. A discussion of “Lessons Learned and Offered,” including various comments about personal therapy (therapist as patient), then completes the article. © 2011 Wiley Periodicals, Inc. J Clin Psychol: In Session 67:1–10, 2011.
Statistical optimization of process parameters for the production of vanillic acid by solid‐state fermentation of groundnut shell waste using response surface methodology
Authors: Gadhe Abhijit , Mudliar Sandeep , Pandey Ramavatar , Elumalai S , Satpute Dewanand 
Published: June 2011

AbstractBACKGROUND: Vanillic acid is a flavoring agent and also serves as precursor for vanillin production. Culture medium and fermentation condition for the single step production of vanillic acid from Phanerochaete chrysosporium using lignocellulosic waste as a substrate under solid state fermentation (SSF) were optimized using response surface methodology.RESULTS: The process parameters were chosen by borrowing methodology, and L‐asparagine, pH and moisture content of the solid medium during SSF were identified as the most significant variables. The optimum value of selected variable and their mutual interactions were determined by response surface methodology. The result demonstrated that a yield of 73.58 mg vanillic acid g−1 substate was predicted under optimum conditions (L‐asparagine 5.98 mmol L−1 (2.37 mg g−1 groundnut shell), pH of solid medium 4.51 and moisture content 74.83%). The predicted response was experimentally validated and resulted in a maximum vanillic acid yield of 73.69 mg g−1 after 8 days of SSF.CONCLUSION: The optimization of fermentation variables resulted in a maximum 10‐fold increase in vanillic acid yield compared with that observed under sub‐optimal conditions (from 7.2 mg g−1 to 73.69 mg g−1). Copyright © 2011 Society of Chemical Industry
Optimization of biodiesel production from crude palm oil using ultrasonic irradiation assistance and response surface methodology
Authors: Worapun Ittipon , Pianthong Kulachate , Thaiyasuit Prachasanti 
Published: June 2011

AbstractBACKGROUND: Production of biodiesel from crude palm oil (CPO) with 6 wt% of free fatty acid (FFA) using a low‐frequency ultrasonic irradiation (40 kHz) technique was investigated in the present work. The objective of this study was to determine the relationship between various important parameters of the alkaline catalyzed transesterification process to obtain a high conversion to biodiesel. Response surface methodology (RSM) was used to statistically analyze and optimize the operating parameters of the process. A central composite design (CCD) was adopted to study the effects of the methanol to oil molar ratio, the catalyst concentration, reaction temperature, and irradiation time on conversion to biodiesel.RESULTS: The result from the RSM analysis indicated that the methanol to oil molar ratio, catalyst concentration and irradiation time have the most significant effects on the conversion to biodiesel. Moreover, a coefficient of determination (R2) value of 0.93 shows the fitness of a second‐order model for the present study. Based on this second‐order model, the optimum conditions for alkaline catalyzed transesterification of CPO were found to be a methanol to oil molar ratio of 6.44:1, catalyst concentration 1.25 wt%, reaction temperature 38.44 °C and irradiation time 25.96 min. At the calculated optimum condition, the conversion to biodiesel reached 97.85%. Under these same conditions, the experimental value was 98.02 ± 0.6%.CONCLUSIONS: The mathematical model developed has been proven to adequately describe the range of the experimental parameters studied and provide a statistically accurate prediction of the optimum conversion to biodiesel. Copyright © 2011 Society of Chemical Industry
Evaluation of focal hepatic lesions with ultrasound contrast agents
Authors: Sutherland Tom , Temple Faye , Lee Wai‐Kit , Hennessy Oliver 
Published: June 2011

AbstractUltrasound contrast agents have gained wide acceptance for the detection and characterization of focal liver lesions. This pictorial essay reviews the growing body of evidence that supports the use of modern ultrasound contrast agents and illustrates the enhancement characteristics of commonly encountered focal liver lesions. Pathologies discussed include metastases, hepatocellular carcinomas, focal nodular hyperplasia, hepatocellular adenomas, hemangiomas, abscesses, complex cysts, and focal fatty deposition. © 2011 Wiley Periodicals, Inc. J Clin Ultrasound, 2011
Prenatal diagnosis of scalp cyst with spontaneous regression
Authors: Bae Jin Young , Seong Won Joon , Lee Taek Hoo , Park Il Soo 
Published: June 2011

AbstractFetal scalp cysts are rare, and they may be easily misdiagnosed as meningoceles or encephaloceles. A 38‐year‐old pregnant woman was referred to our hospital for ultrasound examination, which revealed a small cyst above the skull with no defect in the skull. The cyst could not be seen on follow‐up ultrasound examinations. After delivery, a three‐dimensional CT scan of the head revealed no defect in skull and scalp. Fetal scalp cysts usually require surgical excision after birth, but can regress without any treatment. © 2011 Wiley Periodicals, Inc. J Clin Ultrasound 39:484–486, 2011
Factors predicting prolonged hospital stay for infants with bronchiolitis
Authors: Weisgerber Michael C. , Lye Patricia S. , Li Shun‐Hwa , Bakalarski Deborah , Gedeit Rainer , Simpson Pippa , Gorelick Marc H. 
Published: June 2011

AbstractBACKGROUND:Prior prediction models for length of stay (LOS) in bronchiolitis have focused more on birth‐ and disease‐related risk factors than on early hospital course factors, particularly common clinical markers including respiratory status and caloric intake.OBJECTIVES:1) Study the associations of various clinical markers and LOS; and 2) develop a LOS prediction model.DESIGN:Retrospective cohort study.SETTING:Children's Hospital of Wisconsin.PATIENTS:Inclusion criteria were: age <365 days old; admission between November 1, 2004 and April 15, 2005; final diagnosis of bronchiolitis; placement on the bronchiolitis treatment protocol; and lack of concurrent condition impacting LOS.RESULTS:During the study period, 272/347 infants admitted with bronchiolitis met inclusion criteria. On hospital day 2, infants in the prolonged LOS group (≥108 hours) had a significantly greater number of hours on supplemental oxygen, maximum supplemental oxygen use, minimum supplemental oxygen use, maximum respiratory rate, mean respiratory score, and number of times suctioned. They had significantly lower minimum oxygen saturation and caloric intake. Recursive partitioning demonstrated five variables (hours of supplemental oxygen, maximum respiratory rate, minimum supplemental oxygen use, gestation, and caloric intake) to predict short or prolonged LOS with an area under the receiver‐operator characteristic curve of 0.89/0.72 in the learning/test trees; sensitivity, 0.85; and specificity, 0.82.CONCLUSIONS:There are important differences between infants with bronchiolitis having short and prolonged hospital stays, including several clinical markers identifiable on hospital day 2. This model may be a useful prediction tool for targeting early interventions for high‐risk infants. Journal of Hospital Medicine 2011. © 2011 Society of Hospital Medicine
Leadership conceptual ambiguities
Authors: Brocato Billy , Jelen Jonatan , Schmidt Thomas , Gold Stuart 
Published: June 2011

AbstractThe authors propose a postmodern critique of modernist leadership traits research and offer a robust theoretical and methodological alternative to overcome the ambiguous conceptual use of transformational and charismatic leadership traits. A content analysis of leadership studies from 1999 to 2008 in peer‐reviewed journals and management texts was conducted to identify those salient characteristics often associated with leadership traits. Given the evasive nature of the researched phenomenon and the lack of typical quantitative rigor, our quasi‐meta‐analysis revealed 10 distinctive intrapersonal and interpersonal referents or social perceptions used by researchers when describing leadership traits and the effects of those traits on workers in general. Based on the 10 organizational and social icons deduced from the content analysis, the authors offered a postmodern leadership evaluation matrix as a substitute performance metric in an organizational setting, thus eliminating modernist conceptual ambiguities tied to the leader–worker dyadic in varying organizational contexts. The findings suggest that leadership researchers should consider complex behavioral decision‐making processes that result in emergent group performances instead of focusing on a leader's ephemeral behavioral traits.