bluuebunny/crossref_metadata_2025_split huggingface dataset:
Role of monocyte‐lineage cells in prostate cancer cell invasion and tissue factor expression
Authors: Lindholm Paul F. , Lu Yi , Adley Brian P. , Vladislav Tudor , Jovanovic Borko , Sivapurapu Neela , Yang Ximing J. , Kajdacsy‐Balla André 
Published: July 2010

AbstractBACKGROUNDTissue factor (TF) is a cell surface glycoprotein intricately related to blood coagulation and inflammation. This study was performed to investigate the role of monocyte‐lineage cells in prostate cancer cell TF expression and cell invasion.METHODSProstate cancer cell invasion was tested with and without added peripheral blood monocytes or human monocyte‐lineage cell lines. TF neutralizing antibodies were used to determine the TF requirement for prostate cancer cell invasion activity. Immunohistochemistry was performed to identify prostate tissue CD68 positive monocyte‐derived cells and prostate epithelial TF expression.RESULTSCo‐culture of PC‐3, DU145, and LNCaP cells with isolated human monocytes significantly stimulated prostate cancer cell invasion activity. TF expression was greater in highly invasive prostate cancer cells and was induced in PC‐3, DU145, and LNCaP cells by co‐culture with U‐937 cells, but not with THP‐1 cells. TF neutralizing antibodies inhibited PC‐3 cell invasion in co‐cultures with monocyte‐lineage U‐937 or THP‐1 cells. Prostate cancer tissues contained more CD68 positive cells in the stroma and epithelium (145 ± 53/mm2) than benign prostate (108 ± 31/mm2). Samples from advanced stage prostate cancer tended to contain more CD68 positive cells when compared with lower stage lesions. Prostatic adenocarcinoma demonstrated significantly increased TF expression compared with benign prostatic epithelium.CONCLUSIONSThis study shows that co‐culture with monocyte‐lineage cells induced prostate cancer cell invasion activity. PC‐3 invasion and TF expression was induced in co‐culture with U‐937 cells and partially inhibited with TF neutralizing antibodies. Prostate 70: 1672–1682, 2010. © 2010 Wiley‐Liss, Inc.
Anti‐proliferative effect of a triazole derivative (ST1959) on LNCaP human prostate cancer cells through down‐regulation of cyclin and androgen receptor expression
Authors: Loiarro Maria , Campo Silvia , Arseni Brunilde , Rossi Stefania , D'Alessio Valeria , De Santis Rita , Sette Claudio , Ruggiero Vito 
Published: July 2010

AbstractBACKGROUNDPrevious studies demonstrated that ST1959, a triazole derivative endowed with immunomodulatory activities, also exerts inhibitory effects on proliferation and survival of a panel of tumor cells. In this study, we sought to ascertain the effects of ST1959 on the growth of androgen‐dependent and androgen‐independent prostate cancer (PCa) cells.METHODSThe growth of androgen‐dependent (LNCaP) and androgen‐independent (PC3, DU‐145) cells was analyzed in vitro both in the presence and absence of ST1959. Modulation of cyclin and androgen receptor (AR) expression following treatment with ST1959 was analyzed by Western blot and cytofluorimetric analysis.RESULTSWe observed that ST1959 causes a significant growth inhibition of LNCaP cells without affecting proliferation of androgen‐insensitive DU‐145 and PC3 cell lines. These effects were associated with G0/G1 cell cycle arrest and down‐regulation of cyclin D1, A and B and AR expression.CONCLUSIONSOur present findings indicate that the anti‐proliferative activity of ST1959 on cell growth of androgen‐dependent LNCaP PCa cells may be brought about by decreasing expression of functional AR and selected cyclins, ultimately leading to cell growth inhibition. Prostate 71: 32–41, 2011. © 2010 Wiley‐Liss, Inc.
Strengths and weaknesses of data‐driven docking in critical assessment of prediction of interactions
Authors: de Vries Sjoerd J. , Melquiond Adrien S. J. , Kastritis Panagiotis L. , Karaca Ezgi , Bordogna Annalisa , van Dijk Marc , Rodrigues João P. G. L. M. , Bonvin Alexandre M. J. J. 
Published: July 2010

AbstractThe recent CAPRI rounds have introduced new docking challenges in the form of protein‐RNA complexes, multiple alternative interfaces, and an unprecedented number of targets for which homology modeling was required. We present here the performance of HADDOCK and its web server in the CAPRI experiment and discuss the strengths and weaknesses of data‐driven docking. HADDOCK was successful for 6 out of 9 complexes (6 out of 11 targets) and accurately predicted the individual interfaces for two more complexes. The HADDOCK server, which is the first allowing the simultaneous docking of generic multi‐body complexes, was successful in 4 out of 7 complexes for which it participated. In the scoring experiment, we predicted the highest number of targets of any group. The main weakness of data‐driven docking revealed from these last CAPRI results is its vulnerability for incorrect experimental data related to the interface or the stoichiometry of the complex. At the same time, the use of experimental and/or predicted information is also the strength of our approach as evidenced for those targets for which accurate experimental information was available (e.g., the 10 three‐stars predictions for T40!). Even when the models show a wrong orientation, the individual interfaces are generally well predicted with an average coverage of 60% ± 26% over all targets. This makes data‐driven docking particularly valuable in a biological context to guide experimental studies like, for example, targeted mutagenesis. Proteins 2010. © 2010 Wiley‐Liss, Inc.
On localized surface plasmons of metallic tin nanoparticles in silicon
Authors: Jung Jesper , Pedersen Thomas Garm , Søndergaard Thomas , Pedersen Kjeld , Larsen Arne Nylandsted , Nielsen Brian Bech 
Published: July 2010

AbstractWith plasmonic photovoltaics in mind, electrostatic localized surface plasmon eigenresonances of metallic tin (β‐Sn) nanoparticles buried in crystalline silicon (c‐Si) are analyzed using a Green's function surface integral eigenvalue equation method. We show that by shaping the particles, plasmon resonances can be achieved at wavelengths where c‐Si is a poor light absorber. This might be important for plasmon assisted Si solar cells. (© 2010 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Regulation leads to increases in riparian vegetation, but not direct allochthonous inputs, along the Colorado River in Grand Canyon, Arizona
Authors: Kennedy Theodore A. , Ralston Barbara E. 
Published: July 2010

AbstractDams and associated river regulation have led to the expansion of riparian vegetation, especially nonnative species, along downstream ecosystems. Nonnative saltcedar is one of the dominant riparian plants along virtually every major river system in the arid western United States, but allochthonous inputs have never been quantified along a segment of a large river that is dominated by saltcedar. We developed a novel method for estimating direct allochthonous inputs along the 387 km‐long reach of the Colorado River downstream of Glen Canyon Dam that utilized a GIS vegetation map developed from aerial photographs, empirical and literature‐derived litter production data for the dominant vegetation types, and virtual shorelines of annual peak discharge (566 m3 s−1 stage elevation). Using this method, we estimate that direct allochthonous inputs from riparian vegetation for the entire reach studied total 186 metric tons year−1, which represents mean inputs of 470 gAFDM m−1 year−1 of shoreline or 5.17 gAFDM m−2 year−1 of river surface. These values are comparable to allochthonous inputs for other large rivers and systems that also have sparse riparian vegetation. Nonnative saltcedar represents a significant component of annual allochthonous inputs (36% of total direct inputs) in the Colorado River. We also estimated direct allochthonous inputs for 46.8 km of the Colorado River prior to closure of Glen Canyon Dam using a vegetation map that was developed from historical photographs. Regulation has led to significant increases in riparian vegetation (270–319% increase in cover, depending on stage elevation), but annual allochthonous inputs appear unaffected by regulation because of the lower flood peaks on the post‐dam river. Published in 2010 by John Wiley & Sons, Ltd.
Psychobiological modulation in anxious and depressed patients after a mindfulness meditation programme: a pilot study
Authors: Manzaneque Juan M. , Vera Francisca M. , Ramos Natalia S. , Godoy Yelba A. , Rodriguez Francisco M. , Blanca Maria J. , Fernandez Ana , Enguix Alfredo 
Published: July 2010

AbstractMindfulness meditation is an ancient and simple form of meditation that has been said to induce several important physical and psychological benefits. The present study was designed with the aim of investigating the psychobiological effects of mindfulness meditation practice in a clinical population. Sixteen patients with depression and anxiety symptoms were submitted to a mindfulness meditation programme for the period of 2 months. Psychological well‐being [5‐item Mental Health (MH‐5)] and several endocrine parameters [adrenocorticotropic hormone (ACTH), cortisol, dehydroepiandrosterone‐sulphate (DHEAS), thyroid‐stimulating hormone, triiodothyronine, thyroxine and parathyroid hormone (PTH)] were assessed before and after the meditation programme. At post‐test, the MH‐5 score improved, while the levels of DHEAS and ACTH were raised, and those of PTH decreased. Our results suggest that mindfulness meditation can exert a significant psychobiological modulation by enhancing psychological well‐being, as well as by regulating the levels of several hormonal parameters on different axes. Copyright © 2010 John Wiley & Sons, Ltd.
Making the soft sciences hard: The Newton model
Authors: Simms James R. 
Published: July 2010

AbstractWork has been ongoing, at least since Newton's Principia, to develop a science of life and social phenomena equivalent to the natural sciences such as physics and chemistry. Currently, such a science does not exist. This paper provides the foundation for a science of life and society. The hypothesis of this paper is that the methodologies used to develop the extant natural sciences can be used as a model for developing a natural (hard) life and social science. The natural sciences are typified by identification of fundamental phenomena, measurement of and measurement units for these phenomena and formal equations for the relations among these phenomena. Information is identified as a fundamental phenomenon of life. The natural science methodology is used to develop units of measure for information, and formal equations are developed among behaviours, structural characteristics, available energy and information. This paper shows that information is a measurable universal phenomenon that causes the behaviours of living systems. These developments validate the hypothesis and provide the foundation for natural living systems science. Copyright © 2010 John Wiley & Sons, Ltd.
Distributed in‐network path planning for sensor network navigation in dynamic hazardous environments
Authors: Chen Dazhi , Mohan Chilukuri K. , Mehrotra Kishan G. , Varshney Pramod K. 
Published: July 2010

AbstractWireless sensor networks can be employed to provide distributed real‐time navigation instructions to users attempting to travel in hazardous environments. In this work, we propose a distributed path planning algorithm for sensor network navigation in dynamic hazardous environments. Using geographic or virtual coordinates of sensors and based on a partial reversal method for directed acyclic graphs (DAG), our algorithm constructs a distributed in‐network directed navigation graph, where each source sensor is guaranteed to have at least one desired directed path to one destination sensor. When the hazardous environment changes due to its dynamic nature, path replanning does not need to reconfigure most of the directed links in the graph unaffected by the changes. Correctness of our algorithm is proved and extensive simulation results demonstrate that the constructed navigation graph provides near‐optimal navigation paths for users, successfully adapts to dynamic hazardous environments, and requires very low communication overhead for maintenance, when compared to other navigation graphs constructed by existing algorithms that use frequent or periodic flooding. Copyright © 2010 John Wiley & Sons, Ltd.
A Decomposition Method for Interval Linear Fractional Programming
Authors: Lata Manju , Mittal B. S. 
Published: July 2010

AbstractThe aim of the paper is to obtain a decomposition principle for maximizing a ratio of two linear functions subject to constraints in the ‘interval programming’ form. At each step of the method, two or more linear interval programming problems are to be solved, the optimal solutions of which are written explicitely with the help of Ben‐Israel ‘s and Charnes’ technique. From these solutions, the solution of the original problem is derived according to certain rules. Finally a simple numerical example is solved for illustration.
Strong Shock Wave Propagation in a Mixture of a Gas and Dusty Particles with Gravitational Force
Authors: Pai S. I. , Menon S. , Fan Z. Q. 
Published: July 2010

AbstractWhen a dusty comet collides with a planet, strong shock waves are produced in the dusty gas of the coma. In this case, the gravitational force plays an important role. With gravitational force, similarity solutions [1] of the strong shock wave propagation does not exist. In this paper, we study the effect of the gravitational force in a dusty gas by perturbation theory for the case of large Froude number. Numerical solutions are presented on the velocity, density and pressure distributions behind the shock as well as the shock speeds and its location with time under various conditions. The gravitational force does have predominant influence on the flow fields of the strong shock propagation in a dusty gas.
A (α)‐Stable Cyclic Composite Multistep Methods of Orders 6 and 7 for Numerical Integration of Stiff Ordinary Differential Equations
Authors: Mihelcié M. , Wingerath K. 
Published: July 2010

AbstractWe describe two new A(α)‐stable methods, a 4‐cyclic 4‐step and a 5‐cyclic 5‐step method with P = 6 and P = 7, respectively. This is in contrast to the originally developed methods [5] which have greater order of accuracy (P = 2k) but a small stability region Moreover, the new methods show better stability than the backward differentiation formulas (BDF) in [6] and th cyclic composite methods in [14] of the same order.
Incompatible deformations – plastic intermediate configuration
Authors: Grammenoudis P. , Tsakmakis Ch. 
Published: July 2010

AbstractThere are many approaches in continuum mechanics involving incompatible deformations, one well‐known example being the polar decomposition of the deformation gradient tensor. Such deformations have in the past been regarded rather in the context of local configurations. In the present paper, we discuss incompatible deformations among others, also from the point of view of material lines. Related covariant derivatives and spatial differential operators are introduced and investigated. In particular, it is shown that components of curvature tensors, present in many gradient constitutive theories, may be expressed in terms of the difference between different connections for the same manifold. These issues are illustrated with reference to multiplicative decompositions of deformation gradient tensors into elastic and plastic parts. Two classes of model materials are addressed, non‐polar and micropolar ones.
Functional splicing assay supporting that c.70 + 5G > A mutation in the MPV17 gene is disease causing
Authors: Navarro‐Sastre Aleix , García‐Silva Maria Teresa , Martín‐Hernández Elena , Lluch Montserrat , Briones Paz , Ribes Antonia 
Published: July 2010

AbstractMitochondrial DNA depletion syndrome (MDS) is a group of disorders characterized by a quantitative reduction of the mitochondrial DNA copy number and inherited as autosomal recessive traits. Patients affected by this group of diseases present with a wide variety of symptoms depending on the altered gene. MPV17 is one of the genes causing combined encephalopathy and liver failure and at present there is no treatment for this devastating disease. The gene codes for an inner mitochondrial membrane protein, but its function is still unknown, and therefore, the only way to offer prenatal diagnosis relies on DNA studies. Consequently, mutations have to be well characterized. We previously described a patient homozygous for a novel intronic mutation in the MPV17 gene (c.70 + 5G > A). Here we report the use of a functional splicing assay based on the use of minigenes to support that c.70 + 5G > A mutation is disease causing. We carried out three prenatal diagnoses on three consecutive pregnancies of the previously described family. After two affected fetuses, a healthy baby was born homozygous for the wild‐type allele.
Micellization Behavior of the 14‐2‐14 Gemini Surfactant with Some Conventional Surfactants at Different Temperatures
Authors: Banipal Tarlok Singh , Sood Ashwani Kumar , Singh Kultar 
Published: July 2010

AbstractMixed micellization behavior of the dimeric cationic surfactant ethanediyl‐1,2‐bis(dimethyl tetradecyl ammonium bromide) with monomeric cationic surfactants cetyltrimethyl ammonium bromide (CTAB), cetylpyridinium chloride (CPC), tetradecyl dimethyl benzyl ammonium chloride (C14BCl) and cetyl dimethyl benzyl ammonium chloride (C16BCl) was studied in aqueous and aqueous polyethylene glycol (PEG) solutions at various temperatures (298.15, 308.15 and 318.15 K) using conductometric and viscometric methods. The behavior of these mixed systems was analyzed in light of Rubingh's regular solution theory. The conductivity study indicates that the above systems behave nonideally with mutual synergism at 298.15 and 308.15 K, whereas antagonistic behavior is exhibited at 318.15 K. In the presence of PEG solution, various thermodynamic parameters associated with transfer of surfactant monomers from the medium consisting of polymer‐free mixed micelles to polymer‐bound mixed micelles like ∆Gto, ∆Hto and ∆Sto at various temperatures were evaluated and discussed. The viscosity study shows that in aqueous solutions all these combinations exhibit significant negative departure in the relative viscosity (ηr) from the additivity rule at 298.15 and 308.15 K, whereas at 318.15 K these combinations (except in the case of C14BCl) follow the additivity rule. In presence of 5% PEG solution, all the combinations show positive departure from the additivity rule except the combination with C14BCl which shows negative departure at all the studied temperatures.
Effect of cross‐fostering on seizures in adult male offspring of methamphetamine‐treated rat mothers
Authors: Šlamberová R. , Hrubá L. , Bernášková K. , Matějovská I. , Rokyta R. 
Published: July 2010

AbstractStimulant drugs are often associated with increased seizure susceptibility. Inhibitory γ‐aminobutyric acid (GABA) and excitatory N‐methyl‐d‐aspartate (NMDA) systems play a role in the effect of stimulants in the genesis of epileptic seizures. Our previous studies showed that prenatal methamphetamine (MA) exposure induced long‐term changes in seizure susceptibility. The aim of the present study was to investigate the effect of cross‐fostering on the prenatal and postnatal MA‐exposed rats, respectively, on their seizures in adulthood. Bicuculline (GABAAreceptor antagonist), NMDA (NMDA receptor agonist) and flurothyl (a convulsant gas) were used to induce seizures in adult male offsprings. Female dams were injected with MA (5 mg/kg daily) or physiological saline (S) for approx. 9 week [about 3 week prior to impregnation, for the entire gestation period (22 days) and in preweaning period (21 days)]. Absolute controls (C) did not receive any injections. On postnatal day 1, pups were cross‐fostered so that each mother received pups from all three treatments. Thus, nine groups (based on the prenatal and postnatal drug exposure) of adult male rats were tested in each seizure test: C/C; C/S; C/MA; S/C; S/S; S/MA; MA/C; MA/S; MA/MA. The present study demonstrates that the effect of prenatal and/or postnatal MA exposure is seizure model specific. In addition, our data show that there is an effect of cross‐fostering on seizures; particularly, the effect of prenatal MA exposure shown in animals fostered by control mothers is no longer apparent in animals fostered postnatally by MA‐treated mothers. Such effect of postnatal treatment is not manifested in prenatal controls. In summary, it seems that: (1) prenatal MA exposure alters seizure susceptibility more than postnatal MA exposure; (2) especially in seizures induced by chemicals that affect GABAergic system (bicuculline, flurothyl) notable effect of adoption (cross‐fostering) is apparent; (3) in seizure models that are associated with NMDA system (NMDA, flurothyl), effect of prenatal stress seems to play a role.
Zur theorie- und evidenzbasierten Fundierung massenmedialer Gesundheitskampagnen
Authors: Rossmann Constanze 
Published: July 2010

EinleitungMassenmediale Gesundheitskampagnen gibt es seit Anfang des 20. Jahrhunderts. Ihr Problem ist, dass sie häufig in ihrer Effektivität begrenzt sind, während interpersonale Maßnahmen der Gesundheitsförderung effektiv, aber nicht kosteneffizient einsetzbar sind. Ein Weg zur Verbesserung der Effektivität liegt in einer stärkeren theoretischen Fundierung durch Integration gesundheits- und kognitionspsychologischer sowie kommunikationswissenschaftlicher Erkenntnisse.
Lipidomic analysis of bloodstream and procyclic formTrypanosoma brucei
Authors: RICHMOND GREGORY S. , GIBELLINI FEDERICA , YOUNG SIMON A. , MAJOR LOUISE , DENTON HELEN , LILLEY ALISON , SMITH TERRY K. 
Published: July 2010

SUMMARYThe biological membranes ofTrypanosoma bruceicontain a complex array of phospholipids that are synthesizedde novofrom precursors obtained either directly from the host, or as catabolised endocytosed lipids. This paper describes the use of nanoflow electrospray tandem mass spectrometry and high resolution mass spectrometry in both positive and negative ion modes, allowing the identification of ~500 individual molecular phospholipids species from total lipid extracts of cultured bloodstream and procyclic formT. brucei. Various molecular species of all of the major subclasses of glycerophospholipids were identified including phosphatidylcholine, phosphatidylethanolamine, phosphatidylserine, and phosphatidylinositol as well as phosphatidic acid, phosphatidylglycerol and cardolipin, and the sphingolipids sphingomyelin, inositol phosphoceramide and ethanolamine phosphoceramide. The lipidomic data obtained in this study will aid future biochemical phenotyping of either genetically or chemically manipulated commonly used bloodstream and procyclic strains ofTrypanosoma brucei. Hopefully this will allow a greater understanding of the bizarre world of lipids in this important human pathogen.
Health Care Politics in the Age of Retrenchment
Authors: JORDAN JASON 
Published: July 2010

AbstractThis article examines the debate between the power resources and ‘new politics’ scholars concerning the politics of welfare state retrenchment in advanced industrial democracies. Both approaches make competing claims concerning the relevance of partisan differences in the current age of welfare reform. This article tests the new politics hypothesis that partisanship has had a declining impact on welfare politics over time through an analysis of the growth in the public share of health care spending in 18 countries from 1960 to 2000. Consistent with the new politics approach, the results reveal that the partisan character of government no longer plays a significant role in determining changes in public responsibility for health care during the new politics period. This suggests that the current period is characterised by general agreement across party lines on the broad parameters of the health care system, reducing the intense partisan conflicts of the past to debates over reform at the margins of the health care system.