bluuebunny/crossref_metadata_2025_split huggingface dataset:
Antinociceptive effects of nalbuphine hydrochloride in Hispaniolan Amazon parrots (Amazona ventralis)
Authors: Sanchez-Migallon Guzman David , KuKanich Butch , Keuler Nicholas S. , Klauer Julia M. , Paul-Murphy Joanne R. 
Published: June 2011

Abstract
Objective—To evaluate the antinociceptive effects and duration of action of nalbuphine HCl administered IM on thermal thresholds in Hispaniolan Amazon parrots (Amazona ventralis).
Animals—14 healthy adult Hispaniolan Amazon parrots of unknown sex.
Procedures—3 doses of nalbuphine (12.5, 25, and 50 mg/kg, IM) and saline (0.9% NaCl) solution (control treatment) were evaluated in a blinded complete crossover experimental design by use of foot withdrawal threshold to a noxious thermal stimulus. Baseline data on thermal threshold were generated 1 hour before administration of nalbuphine or saline solution; thermal threshold measurements were obtained 0.5, 1.5, 3, and 6 hours after administration.
Results—Nalbuphine administered IM at 12.5 mg/kg significantly increased the thermal threshold (mean change, 2.4°C), compared with results for the control treatment, and significantly changed thermal threshold for up to 3 hours, compared with baseline results (mean change, 2.6° to 3.8°C). Higher doses of nalbuphine did not significantly change thermal thresholds, compared with results for the control treatment, but had a significant effect, compared with baseline results, for up to 3 and 1.5 hours after administration, respectively.
Conclusions and Clinical Relevance—Nalbuphine administered IM at 12.5 mg/kg significantly increased the foot withdrawal threshold to a thermal noxious stimulus in Hispaniolan Amazon parrots. Higher doses of nalbuphine did not result in significantly increased thermal thresholds or a longer duration of action and would be expected to result in less analgesic effect than lower doses. Further studies are needed to fully evaluate the analgesic effects of nalbuphine in psittacine species.
Pharmacokinetics of nalbuphine hydrochloride after intravenous and intramuscular administration to Hispaniolan Amazon parrots (Amazona ventralis)
Authors: Keller Dominique L. , Sanchez-Migallon Guzman David , Klauer Julia M. , KuKanich Butch , Barker Steven A. , Rodríguez-Ramos Fernández Julia , Paul-Murphy Joanne R. 
Published: June 2011

Abstract
Objective—To assess the pharmacokinetics of nalbuphine HCl after IV and IM administration to Hispaniolan Amazon parrots (Amazona ventralis).
Animals—8 healthy adult Hispaniolan Amazon parrots of unknown sex.
Procedures—Nalbuphine HCl (12.5 mg/kg) was administered IV and IM to all birds in a complete randomized crossover study design; there was a washout period of 21 days between subsequent administrations. Plasma samples were obtained from blood collected at predetermined time points for measurement of nalbuphine concentration by use of liquid chromatography–tandem mass spectrometry. Pharmacokinetic parameters were estimated by use of computer software.
Results—Nalbuphine was rapidly eliminated with a terminal half-life of 0.33 hours and clearance of 69.95 mL/min/kg after IV administration and a half-life of 0.35 hours after IM administration. Volume of distribution was 2.01 L/kg after IV administration. The fraction of the dose absorbed was high (1.03) after IM administration. No adverse effects were detected in the parrots during the study.
Conclusions and Clinical Relevance—In Hispaniolan Amazon parrots, nalbuphine appeared to have good bioavailability after IM administration and was rapidly cleared after IV and IM administration. Safety and analgesic efficacy of various nalbuphine treatment regimens in this species require further investigation to determine the potential for clinical palliation of signs of pain in psittacine species.
Accuracy of pressure plate kinetic asymmetry indices and their correlation with visual gait assessment scores in lame and nonlame dogs
Authors: Oosterlinck Maarten , Bosmans Tim , Gasthuys Frank , Polis Ingeborgh , Van Ryssen Bernadette , Dewulf Jeroen , Pille Frederik 
Published: June 2011

Abstract
Objective—To determine the accuracy of pressure plate kinetic asymmetry indices (ASIs) for diagnosis of unilateral hind limb lameness in dogs and their correlation with visual gait assessment (VGA) scores.
Animals—9 healthy dogs and 16 dogs with previously diagnosed unilateral rupture of the cranial cruciate ligament and concurrent unilateral hind limb lameness.
Procedures—Dogs were walked over a pressure plate to determine paw contact area (PCA), peak vertical pressure (PVP), peak vertical force (PVF), and vertical impulse (VI) of both hind limbs. An ASI was calculated for each gait variable. Simultaneously, gait was assessed visually and scored by use of a numeric rating scale (0 to 10). The ASI of each variable was tested for its usefulness in discrimination between lame and nonlame dogs and for correlation with VGA scores.
Results—Sensitivity and specificity of ASIs to discriminate between lame and nonlame dogs were excellent for PVF, VI, and PCA; these values were substantially lower for ASI of PVP. Cutoff values to discriminate between lame and nonlame dogs were determined by use of ASIs for PVF, VI, and PCA; however, this could not be done for ASI of PVP. Correlations between ASIs of PVF, VI, and PCA and VGA scores were higher than correlation between the ASIs of PVP and VGA scores.
Conclusions and Clinical Relevance—Results indicated that ASIs of PVF and VI determined via analysis of pressure plate measurements were reliable indicators of clinical lameness in dogs, but the ASI of PVP was not. The ASI of PCA is an interesting new variable for assessment of limb loading symmetry.
Diagnostic accuracy of using erythrocyte indices and polychromasia to identify regenerative anemia in dogs
Authors: Hodges Joanne , Christopher Mary M. 
Published: June 2011

Abstract
Objective—To determine diagnostic accuracy of using erythrocyte indices and polychromasia to identify regenerative anemia in dogs.
Design—Retrospective and prospective cross-sectional study.
Animals—4,521 anemic dogs.
Procedures—CBC results obtained between July 2002 and July 2008 by use of an automated laser-based flow cytometric hematology analyzer from dogs with Hct values ≤ 35% were retrieved. Sensitivity, specificity, accuracy, and predictive values of using erythrocyte indices and polychromasia to identify regeneration were determined, with a reticulocyte count > 65,000 reticulocytes/μL considered the gold standard. Similarly, 134 blood samples from anemic dogs were analyzed prospectively with an in-house electrical impedance analyzer.
Results—Of 4,387 dogs with samples analyzed retrospectively, 1,426 (32.5%) had regenerative anemia. Of these, 168 (11.8%) had macrocytic hypochromic anemia. High mean cell volume and low mean cell hemoglobin concentration had low sensitivity (11%), high specificity (98%), and moderate accuracy (70%) when used to identify regenerative anemia. Use of polychromasia alone had an accuracy of 77%, and use of polychromasia combined with a high RBC distribution width (RDW) had an accuracy of 79%. Results obtained with the in-house analyzer were similar.
Conclusions and Clinical Relevance—Results suggested that most regenerative anemias in dogs were not macrocytic hypochromic. Polychromasia, with or without high RDW, was a more accurate indicator than other erythrocyte indices of regenerative anemia. To avoid a false diagnosis of nonregenerative anemia, a blood smear should be evaluated in anemic dogs when a reticulocyte count is not available.
Ecological status of shallow Lake Gorbacz (NE Poland) in its final stage before drying up
Authors: Zieliński Piotr , Ejsmont-Karabin Jolanta , Grabowska Magdalena , Karpowicz Maciej 
Published: June 2011

Abstract
The article assesses the ecological status of shallow Gorbacz Lake (NE Poland) in the last stage before complete drying up. For last few years hydrological regime of the lake catchment has been changed dramatically which was caused by functioning nearby peat mine and longer autumn drought periods for following years. Progressing macrophytes succession leaded complete emergent macrophytes overgrowth of the lake beginning from 2000. The analyses include records of previous samples and data for morphology, water quality, phytoplankton, zooplankton and macrophytes. The trophic status of Gorbacz Lake was verified compare to the previous studies. The results indicate that even with minimum amount of water Gorbacz Lake itself still keeps its dystrophic character with increasing of water color and of DOC, biogenic substances, chlorophyll a concentrations. Humic State Index (HSI) and hydrochemical dystrophy index (HDI) confirm the dystrophic status of the lake with values 71.3 and 76.2 respectively. Both typical phytoplankton representatives of eutrophic and dystrophic waters were recorded. Very high diversity of desmids in the telmatoplankton, indicates the observed process of shallowing in the reservoir. Planktonic crustacean fauna was represented by small filtrators. Rotifera community was strongly dominated by Trichocerca simonei. The article concludes with the main causes of the observed changes and some future remarks for the lake state.
Comparison of gastrotrich fauna on elodeids and in bottom sediments of lakes of different trophic status (the region Polesie Lubelskie, Eastern Poland)
Authors: Nesteruk Teresa 
Published: June 2011

Abstract
Species diversity of gastrotrich communities on elodeids and in bottom sediments of lakes of different trophic status was compared. Thirty-eight species of Gastrotricha (34 in bottom sediment and 21 on elodeids) were found, which belong to the only family of Chaetonotidae Zelinka, 1889. Species diversity of both habitats was reflected in the diversity indices ranging from 2.02 (a dystrophic lake) to 2.67 (a strongly eutrophic lake) for bottom sediment, and from 2.01 (a mesotrophic lake) to 2.54 (a strongly eutrophic lake) for elodeids. The similarity of gastrotrich fauna from the two habitats was low, and varied from 17% (a mesotrophic lake) to 38% (a strongly eutrophic lake). Low similarity of elodeid fauna from lakes of different trophic status was also found, in spite of similar plant species composition. The lowest similarity in elodeid fauna (23%) was recorded for dystrophic and mesotrophic lakes, whereas the highest one (68%) was observed for eutrophic and strongly eutrophic lakes. That allows to conclude that the diversity of epiphytic fauna is affected by trophic status rather than by vegetation type. The comparison of the gastrotrich fauna from elodeids and bottom sediments in lakes of different trophic status provides additional autoecological characteristics of Heterolepidoderma ocellatum (Mečnikow, 1865) and allows to recognize this species as belonging to a group of species closely related to macrophytes.
Phosphate exchange across the sediment-water interface under oxic and hypoxic/anoxic conditions in the southern Baltic Sea
Authors: Łukawska-Matuszewska Katarzyna , Burska Dorota 
Published: June 2011

Abstract
Benthic fluxes of phosphate and phosphorus distribution in sediments from the southern Baltic Sea were investigated in spring and autumn in 2005 and 2007–2010. Strong spatial variability of phosphate fluxes was observed across the sediment-water interface. The highest values of phosphate flux from sediment (up to 37 μmol m−2 h−1), resulting from the high mineralization rate of organic matter and rapid phosphorus turnover due to macrofaunal activity and hydrodynamic conditions, were observed in the shallow area at depths ranging from 50 to 69 m. The rate of phosphate exchange in the transportation and accumulation bottom area with the water depth ≥72 m was several times lower (2.12–6.22 μmol m−2 h−1). In continuously hypoxic or anoxic sediments, phosphorus was preserved in the refractory organic form, and sediments were depleted of redox-dependent phosphorus forms. In shallow area with well oxygenated near-bottom water, phosphorus was present mainly in the calcium-bound form.
Phosphorus in sediments and pore waters of selected Polish dam reservoirs
Authors: Trojanowska Adriana , Jezierski Piotr 
Published: June 2011

Abstract
This study aimed to examine and explain the spatial distribution of total phosphorus in sediments and orthophosphates in interstitial water in four Polish dam reservoirs with varying hydrological and geochemical characteristics. The results are linked to physicochemical parameters of sediments: organic matter and calcium carbonates content, pH, redox potential and conductivity.
In two of the studied reservoirs hydrological dynamics were a driving force in phosphorus circulation, despite the big difference in their mean water retention times, and interactions with Ca and Fe were of secondary importance
In other reservoirs with complicated shorelines and reservoir beds, due to water flow disturbance the hydrological impact was not as pronounced. Geochemical processes, such as precipitation of phosphorus associated with Ca+2, Fe(III) or in complexed with humic substances became more significant.
On the use of a simple primary productivity model to assess the skill of a physical ocean model
Authors: Kantha Lakshmi , Carniel Sandro , Clayson Carol , Sclavo Mauro 
Published: June 2011

Abstract
Ecosystem models, used mainly in studying the interactions between different trophic levels, can also be used for ocean circulation model skill assessment, with the help of satellite ocean color data. This paper presents how the use of a simple NPZ primary productivity ecosystem model, coupled to a hydrodynamical model, can help assessing the skill of the physical ocean model in depicting realistically the prevailing mesoscale features of the upper layers of the Gulf of Mexico. Results indicate that the physical model effectively reproduces the mesoscale features of circulation underlying the resulting chlorophyll concentrations, especially when circulation fronts exist.
Estimation and Identification of the Complier Average Causal Effect Parameter in Education RCTs
Authors: Schochet Peter Z. , Chiang Hanley S. 
Published: June 2011

In randomized control trials (RCTs) in the education field, the complier average causal effect (CACE) parameter is often of policy interest, because it pertains to intervention effects for students who receive a meaningful dose of treatment services. This article uses a causal inference and instrumental variables framework to examine the identification and estimation of the CACE parameter for two-level clustered RCTs. The article also provides simple asymptotic variance formulas for CACE impact estimators measured in nominal and standard deviation units. In the empirical work, data from 10 large RCTs are used to compare significance findings using correct CACE variance estimators and commonly used approximations that ignore the estimation error in service receipt rates and outcome standard deviations. The key finding is that the variance corrections have very little effect on the standard errors of standardized CACE impact estimators. Across the examined outcomes, the correction terms typically raise the standard errors by less than 1%, and change p values at the fourth or higher decimal place. Manuscript received April 16, 2010 Revision received April 26, 2010 Accepted May 24, 2010
Hemodynamic instability following carotid artery stenting
Authors: Kojuri Javad , Ostovan Mohammad Ali , Zamiri Nima , Farshchizarabi Sara , Varavipoor Bahman 
Published: June 2011

Object
Postprocedural hypotension and bradycardia are important complications of carotid artery stenting (CAS) and are referred to as hemodynamic instability (HI). However, the incidence and impact of HI on the short-term prognosis of patients have been of a large debate.

Methods
Twenty-seven patients were selected based on NASCET criteria, and they underwent CAS between September 2008 and September 2009. Continuous electrocardiography monitoring and supine blood pressure (BP) monitoring were performed before and after stent deployment and on the following day to detect HI, defined as systolic BP lower than 90 mm Hg or a heart rate lower than 60 bpm. Patients were asked to perform a Valsalva maneuver before and after stent deployment. The Valsalva ratios (VRs) along with other demographic and procedural data were documented and compared between patients with and without incidence of HI.

Results
Seventeen patients (63%) developed HI after CAS. The degree of stenosis was found to have a significant correlation with occurrence of HI (p < 0.006). No other risk factor or demographic data showed any correlation with HI. The VRs were significantly lower in the HI group compared with the non-HI group, indicating a significant autonomic dysfunction (p < 0.003). During follow-up, 1 patient (4.3%) developed major stroke, and the remaining patients were symptom free.

Conclusions
Hemodynamic instability occurs frequently after CAS, but it seems to be a benign phenomenon and does not increase the risk of mortality or morbidity in the short term. A VR at rest less than 1.10, baseline autonomic dysfunction, and degree of carotid artery stenosis can be used as measures for predicting HI after CAS.
The relationships between endothelial nitric oxide synthase polymorphisms and the formation of intracranial aneurysms in the Korean population
Authors: Kim Tae Gon , Kim Nam Keun , Baek Min Jung , Huh Ryoung , Chung Sang Sup , Choi Joong Uhn , Yu So Young 
Published: June 2011

Object
Some genetic factors are known to be associated with the formation of cerebral aneurysms in the Caucasian population. One of these factors is endothelial nitric oxide synthase (eNOS) gene polymorphisms. Endothelial nitric oxide synthase genes encode eNOS, which synthesizes NO from l-arginine. There continues to be controversy about the relationships between eNOS gene polymorphisms and the formation of intracranial aneurysms. In this study, the authors evaluated these relationships in the Korean population.

Methods
Three eNOS polymorphisms (eNOS 27VNTR, T786C, and G894T) were genotyped in 96 patients with ruptured aneurysms, 53 patients with unruptured aneurysms, and in 121 volunteers via polymerase chain reaction–restriction fragment length polymorphism analysis.

Results
The mean ages of the patients and healthy volunteers were 52.9 ± 12.3 years and 55.2 ± 9.1 years, respectively. The patient group was composed of 56 men and 93 women, and the healthy volunteer group was composed of 46 men and 75 women. Only the incidence of smoking history was significantly higher in the patient group than in the control group (p = 0.001). The genotypic frequencies for the 3 eNOS gene polymorphisms were in agreement with those predicted by Hardy-Weinberg equilibrium. There were no significant associations between the eNOS recessive models and the formation of an aneurysm. The authors found no genotypic differences between similar races among patients with aneurysms.

Conclusions
The present study shows that eNOS 27VNTR, T786C, and G894T polymorphisms cannot be used as indicators of the formation of intracranial aneurysms in Korean patients. To confirm these findings an additional analyses might need to be performed using a larger sample size. There were no differences in the genotypic distributions and allelic frequencies between similar races among patients with aneurysms, which were the same in previously reported normal populations.
Endovascular recanalization of symptomatic flow-limiting cervical carotid dissection in an isolated hemisphere
Authors: Schirmer Clemens M. , Atalay Basar , Malek Adel M. 
Published: June 2011

Object
Internal carotid artery dissection (ICAD) is a common cause of stroke in young patients, which may lead to major transient or permanent disability. Internal carotid artery dissection may occur spontaneously or after trauma and may present with a rapid neurological deterioration or with hemodynamic compromise and a delayed and unstable neurological deficit. Endovascular intervention using stent angioplasty can be used as an alternative to anticoagulation and open surgical therapy in this setting to restore blood flow through the affected carotid artery.

Methods
The authors present the cases of 2 patients with flow-limiting symptomatic ICAD leading to near-complete occlusion and without sufficient collateral supply. Both patients had isolated cerebral hemispheres without significant blood flow from the anterior or posterior communicating arteries. In both cases, the patients demonstrated blood pressure–dependent subacute unstable neurological deficits as a result of the hemodynamic compromise resulting from the dissection.

Results
Both patients underwent careful microwire-based selection of the true lumen followed by confirmatory microinjection and subsequent exchange-length microwire-based recanalization using tandem telescoping endovascular stenting. In both cases the neurological state improved, and no permanent neurological deficit ensued.

Conclusions
The treatment of ICAD may be difficult in patients with subacute unstable neurological deficits related to symptomatic hypoperfusion, especially in the setting of a hemodynamically isolated hemisphere. Anticoagulation alone may be insufficient in these patients. Although there is no widely accepted guideline for the treatment of ICAD, the authors recommend stent-mediated endovascular recanalization in cases of symptomatic flow-limiting hemodynamic compromise, especially in cases of an isolated hemisphere lacking sufficient communicating artery compensatory perfusion.
Sources of variability in computed tomography perfusion: implications for acute stroke management
Authors: Zussman Benjamin , Jabbour Pascal , Talekar Kiran , Gorniak Richard , Flanders Adam E. 
Published: June 2011

Object
Although dynamic, first-pass cerebral CT perfusion is used in the evaluation of acute ischemic stroke, a lack of standardization restricts the value of this imaging modality in clinical decision-making. The purpose of this study was to comprehensively review the reported sources of variability and error in cerebral CT perfusion results.

Methods
A systematic literature review was conducted, 120 articles were reviewed, and 23 published original research articles were included. Sources of variability and error were thematically categorized and presented within the context of the 3 stages of a typical CT perfusion study: data acquisition, postprocessing, and results interpretation.

Results
Seven factors that caused variability were identified and described in detail: 1) contrast media, the iodinated compound injected intravascularly to permit imaging of the cerebral vessels; 2) data acquisition rate, the number of images obtained by CT scan per unit time; 3) user inputs, the subjective selections that operators make; 4) observer variation, the failure of operators to repeatedly measure a perfusion parameter with precision; 5) software operational mode, manual, semiautomatic, or automatic; 6) software design, the mathematical algorithms used to perform postprocessing; and 7) value type, absolute versus relative values.

Conclusions
Standardization at all 3 stages of the CT perfusion study cycle is warranted. At present, caution should be exercised when interpreting CT perfusion results as these values may vary considerably depending on a variety of factors. Future research is needed to define the role of CT perfusion in clinical decision-making for acute stroke patients and to determine the clinically acceptable limits of variability in CT perfusion results.