bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluation of golden proportions among three ethnic groups of Indian females
Authors: Irengbam Devina , Yadav Ashish , Misra Vaibhav , Attri Sonal , Yenaganti Sai Teja 
Published: June 2024

The study aimed to assess and compare the presence of golden proportions among three ethnic groups of Indian females: North Indian, North East Indian, and South Indian. Understanding ethnic variations in facial measurements and assessments related to golden proportions has implications for aesthetic treatments and facial reconstruction procedures.A cross-sectional observational study was conducted, involving 150 Indian females aged 18-35 years from the three ethnic groups. Facial measurements were collected using photographs captured using high-resolution Canon EOS 1500D camera with 18-55mm & 55-250 mm macro lens. Evaluators independently assessed facial photographs based on the golden proportion principle of Ricketts’ Golden Ratio. Statistical analyses, including Analysis of Variance (ANOVA) and post-hoc tests were performed to compare the measurements and assessments among the ethnic groups.Statistically significant differences in facial measurements and assessments were observed among the North Indian, North East Indian, and South Indian ethnic groups. The TR - ME:LC-ME (Total Facial Height: Length of face between Lateral Canthus of Eyes to Menton) was exactly in relation to the golden proportions in all three groups. The total facial height was thus in golden proportion to the middle and lower facial sections in all three groups. LNr:CHr and TSr:LCr were similar to the golden proportion in North Indian and North East Indian ethnicity, while LNr:CHr was similar to the golden proportion in South Indian ethnicity. Variations in intercanthal distance, interalar width, and philtrum height indicated distinct facial proportions within each ethnic group. The evaluators' assessments of facial proportions also varied significantly among the ethnic groups, highlighting the influence of cultural and societal beauty standards on aesthetic perceptions.The study findings underscore the importance of considering ethnic variations in golden proportions when planning aesthetic treatments and facial reconstruction procedures for Indian females. Recognizing and appreciating the diversity in facial aesthetics can lead to more personalized and culturally sensitive care, resulting in enhanced patient satisfaction and outcomes. Further research is needed to explore golden proportions in other ethnic groups and their impact on treatment preferences and outcomes.
Comparative evaluation of the efficiency of canine retraction using modified marcotte and opus loop – A split mouth, randomized clinical trial
Authors: Suresh Harshitha , P Rajakumar 
Published: June 2024

To Compare the efficiency of canine retraction using modified Marcotte and Opus loop. Patients with all first premolar extraction were fitted with Opus and Modified Marcotte loop on left and right side of maxillary arch. Rate of canine retraction was evaluated after 3-months using digital Vernier Callipers on procured models, Lateral cephalograms, and OPG. Average retraction with Modified Marcotte loop using TMA wire was 2.5±0.5 mm and Opus Loop using TMA wire was 3.8±0.5mm for the period of three months. Average retraction with Modified Marcotte loop using TMA wire was 1.1 mm and Opus Loop using TMA wire was 0.77 mm for the period of three months. Greater amount of maxillary canine retraction occurred using the 0.017 × 0.025 TMA Opus loop (3.8 mm) as compared to the 0.017 × 0.025 TMA Modified Marcotte loop (2.5 mm).The anchorage loss with Modified Marcotte loop is more (1.1mm) compared to Opus loop (0.07mm). The 0.017 × 0.025 TMA Modified marcotte loop showed 15.75° tipping, whereas the 0.017 × 0.025 TMA Opus loop showed 6.75° tipping, indicating that the Opus loop had better control.
Natural head positioner (NHP) – A guiding device for diagnosis and treatment planning in orthodontics
Authors: Nakhate Trupti , Marure Pravinkumar S , Mukhedkar Nikhil 
Published: June 2024

The Natural head position in orthodontics is a highly precise, reliable, and reproducible external reference position that is used in clinical diagnosis and research. The physics concept that states that the fluid levels of a liquid's surface is horizontal in a non-accelerating fluid system (hydrostatic). The fluid surface has a tendency to align with gravity at an angle of 90 degrees. The two locations in a fluid level where the fluid, glass, and air converge will naturally aim for the same level similar to gravity. This device was designed to capture the head posture of the patient in its natural state before clinical extra-oral photography and head film exposure. A simplified fluid-level device in conjunction with a standardized procedure and cephalometric radiography yielded a consistently determined and recorded value. A simple technique for accurately recording NHP and recreating it.
Comportamento alimentar de crianças e adolescentes com Transtorno do Espectro do Autismo (TEA) na perspectiva da Segurança Alimentar e Nutricional
Authors: Silva Letícia Marinho Alves da , Augusto Ana Lúcia P. , Souza Thais Salema Nogueira de 
Published: June 2024

OBJETIVO: O objetivo principal desta pesquisa foi conhecer as experiências e demandas no âmbito alimentar de mães, pais, responsáveis e cuidadores de crianças e adolescentes com diagnóstico de Transtorno do Espectro do Autismo (TEA), além de compreender as dimensões do comportamento alimentar que se encontram alteradas em crianças e adolescentes autistas e se relacionam com a Segurança Alimentar e Nutricional. MATERIAIS E MÉTODOS: Trata-se de uma pesquisa quantitativa, realizada com 44 responsáveis por crianças e adolescentes com TEA, por meio da aplicação de um questionário estruturado para coleta de dados sociodemográficos e da Escala Labirinto de Avaliação do Comportamento Alimentar no TEA. Foi realizada análise descritiva dos dados. RESULTADOS: Dentre as alterações no comportamento alimentar foram encontradas alterações na motricidade na mastigação, seletividade alimentar, comportamento opositor relacionado a alimentação, além de alergias e intolerâncias alimentares na maioria dos casos. CONCLUSÃO: Os resultados revelam comportamentos que põem em risco a Segurança Alimentar e Nutricional de crianças e adolescentes autistas. Assim, se torna relevante a atuação nutricionista no suporte e apoio à atenção nutricional com práticas alimentares adequadas ao contexto de vida desse público.
Ischemic heart disease and cardiac arrhythmia are associated with increased cardiac aging
Authors: Salih Ahmed , Rauseo Elisa , Galazzo Ilaria , Pujadas Esmeralda Ruiz , Campello Victor , Lekadir Karim , Aung Nay , Slabaugh Greg , Dabbagh Ghaith , Chahal Anwar , Menegaz Gloria , Petersen Steffen 
Published: June 2024

Abstract

Ischemic heart disease (IHD) and cardiac arrhythmia (CA) patients experience alterations in cardiac structure and function which can speed up cardiac aging. Estimating biological heart age using cardiac magnetic resonance (CMR) and electrocardiogram (ECG)-derived phenotypes provides a biomarker for cardiac aging. We investigated the impact of IHD and CA on cardiac aging using biological age estimation biomarkers, and the role of age-related cardiac changes and vascular risk factors (VRF)s using data from United Kingdom Biobank. Cardiac age was estimated in prevalent IHD (n = 2,142) and CA (n = 1,683) subjects using a Bayesian ridge regression model with CMR radiomics and ECG features. Heart age gap (HAG), the difference between predicted and chronological heart age, was calculated. Mediation analysis explored CMR metrics as mediators in the HAG-cardiac disease association. The association of HAG and VRFs in each disease cohort was also analysed. IHD subjects had significantly increasing heart age (HAG: 1.55 years ± 5.66; p < 0.001), as did CA individuals (HAG: 1.57 years ± 5.77; p < 0.001). Conventional CMR metrics describing normal age-related changes partially mediated the effect of disease on HAG. High adiposity contributed most to increasing HAG in IHD, followed by hypertension. Hypertension had the greatest impact on cardiac aging, followed by high cholesterol in CA.
A preliminary study of calcite saturation states with varying pH and salinity
Authors: Heng Boaz Chung Yi , Joynson Jerry , Willis Steve , Khoiroh Ianatul , Koyande Apurav Krishna , Foo Dominic 
Published: June 2024

Abstract

The present work explores accelerated weathering of limestone (AWL) as an option to combat the climate change problem posed by the still growing carbon footprint. AWL is a promising low-technology solution that sequesters CO2 through the dissolution of calcium carbonate (CaCO3) in water to form calcium bicarbonate. One aspect of the feasibility of its application is whether the newly formed bicarbonate will remain in solution for the long term. This paper examines the carbonate equilibria for various water bodies by combining Bjerrum plots with the calcite saturation value, omega. The hydrochemistry software, aqion, was used to simulate a range of water compositions with different salinities at various conditions. The study compares saturation states of rainwater, limestone quarry water, seawater, and reverse osmosis concentrate, with their respective dissolved inorganic carbon (DIC) concentrations, across the full range of pH values. The areas of stability and instability can be observed from the generated plots in order to be able to design effective AWL processes. A key issue for successful implementation of AWL is operating within the CaCO3 saturation limit and ensuring dissolved material does not subsequently reprecipitate.
Predicting Exploration Crew Medical Officer Training Needs
Applying Evidence Based Predictive Analytics to Space Medicine Training
Authors: Levin Dana , McIntyre Lauren , Steller Jon , Nelson Ariana , Zahner Chris , Anderson Arian , Parmar Prashant , Hilmers David 
Published: June 2024

Abstract

Predictive analytics may be a useful adjunct to identify training needs for exploration class medical officers onboard deep space vehicles.

This study used a preliminary version of NASA’s newest medical predictive analytics tool, the Medical Extensible Database Probabilistic Risk Assessment Tool (MEDPRAT), to test the application of predictive analytics to Exploration Crew Medical Officer (exploration CMO) curriculum design for 5 distinct mission profiles. Curriculum elements were identified using a leave-one-out analysis and a threshold of 5% risk increase over the fully treated baseline.

This proof-of-concept study demonstrated that predictive analytics can rapidly generate generic and mission profile specific exploration CMO curricula using an evidence-based process driven by optimizing mission risk reduction. This technique may serve as part of a human-machine team approach to medical curriculum planning for future space missions. It has significant potential to improve astronaut health and save time and effort for both planners and trainees.
Low Efficiency of Homology-Independent Targeted Integration for CRISPR/Cas9 Correction in the Vicinity of SLC26A4 c.919–2A&gt;G Variant
Authors: Wu Chen-Chi , Chan Yen-Hui , Ho Chang-Han , Tsai Cheng-Yu , Chang Chi-Chieh , Hu Chin-Ju , Lu Ying-Chang , Lin Pei-Hsuan , Cheng Yen-fu , Lin Chin-Hsien , Lin Han-I , OuYang Chih-Hsin , Hsu Chuan-Jen , Liu Tien-Chen , Chen You-Tzung , Huang Cheng-Yen 
Published: June 2024

Abstract

Recessive variants of SLC26A4 are a common cause of hereditary hearing impairment and are responsible for non-syndromic enlarged vestibular aqueducts and Pendred syndrome. Patients with bi-allelic SLC26A4 variants often suffer from fluctuating hearing loss and recurrent vertigo, ultimately leading to severe to profound hearing impairment. However, there are currently no satisfactory prevention or treatment options for this condition. The CRISPR/Cas9 genome-editing technique is a well-known tool for correcting point mutations or manipulating genes and shows potential therapeutic application for hereditary disorders. In this study, we attempted to use the homology-independent targeted integration (HITI) strategy to correct the SLC26A4 c.919-2A > G variant, the most common SLC26A4 variant in the Han Chinese population. Next-generation sequencing was performed to evaluate the editing efficiency of the HITI strategy. The results showed that only 0.15% of the reads successfully exhibited HITI integration, indicating that the c.919-2 region may not be a suitable region for HITI selection and that other site selection or insertion strategies may be needed to improve the efficiency of correcting the SLC26A4 c.919-2A > G variant. This experience may serve as a valuable reference for other researchers considering CRISPR target design in this region.
Impact of Vitamin D Suplementation in Clinical Outcome at Tuberculosis Spondylitis : Randomized Controlled Trial
Authors: Arifin Jainal , Massi Muhammad Nasrum , Biakto Karya Triko , Bukhari Agussalim , Usman Muhammad Andry , Hamid Firdaus , Adnan Endy , Johan Muhammad Phetrus , Zainuddin Andi Alfian 
Published: June 2024

Abstract

Mycobacterium tuberculosis (MTB) causes infectious bacterial disease. Most cases of musculoskeletal tuberculosis affect vertebrae which cause spinal tuberculosis (spondylitis), extrapulmonary tuberculosis. Vitamin D deficiency have higher risk in tuberculosis infection. Vitamin D had role in the activation processes on immune cell which eliminate tuberculosis infection. The aim of the study is to assess the impact of oral supplementation of serum vitamin D on clinical outcome in spinal tuberculosis. The study design is randomized controlled trial. Total partisipants is 36 samples. The inclusion criteria were spinal tuberculosis patients diagnosed with MRI and GenExpert. The exclusion criteria were pulmonary tuberculosis, partisipant with other chronic disease such as diabetes, autoimun, malabsorption syndrome. Vitamin D serum levels were measured by ELISA method. There is a significant increasing serum levels of vitamin D in the study group were observed after 4 and 8 supplementation (p< 0.05). On the assessment of ODI and VAS, it decrease significantly in the three groups after 8 weeks of vitamin D supplementation (p<0.05), but in group 10.000 IU also decrease ODI and VAS score significant after 4 weeks supplementation.
Trial Registration
This study had clinical trial approved by U.S National Library of Medicine (NCT05376189, May 17, 2022).
Objective evaluation of skin stiffness in breast cancer-related lymphedema using MyotoPRO
Authors: Mitsuoka Hiroki , Arima Takahiro , Ito Yukie , Fujii Kimihito , Otsuka Shun , Shan Xiyao , Shima Miki , Takagi Kensuke , Osawa Mitsuharu , Naito Munekazu , Nakano Shogo , Kodama Akio 
Published: June 2024

Abstract

Purpose
Severe lymphedema leads to a decline in quality of life. Skin stiffness is one of the symptoms of lymphedema; however, no objective method has been established to evaluate this symptom. We aimed to examine whether MyotonPRO, which is used to evaluate muscle and fascia stiffness, could evaluate skin stiffness in upper limb lymphedema.
Methods
Female patients with breast cancer-related lymphedema (BCRL) after unilateral breast cancer surgery were included. Stiffness by MyotonPRO and circumference were measured on both sides 5 and 10 cm from the elbow joint of the forearm and upper arm, respectively. Measurements were compared between the normal and lymphedema limbs. History of breast cancer, lymphedema and comorbidities were collected from medical records, and the relationship with skin stiffness was evaluated.
Results
The skin stiffness values of normal and lymphedema limbs were 249 ± 50 and 283 ± 56 N/m (p < 0.001) in the upper arm and 306 ± 44 and 353 ± 64 N/m (p < 0.001) in the forearm, respectively, and were significantly greater in the lymphedema limb. The circumferences of the normal and lymphedema limbs were 27.5 ± 3.6 and 29.1 ± 4.0 cm (p < 0.001) for the upper arm and 23.7 ± 2.4 and 25.1 ± 2.9 cm (p < 0.001) for the forearm, respectively, in which the lymphedema limb was significantly larger. In the multiple regression analysis, diabetes had the greatest effect on the lymphedema limb stiffness.
Conclusion
MyotonPRO can objectively assess chronic skin stiffness in BCRL.
Genotypic and Physiological Evaluation of Mungbean (Vigna radiata) for Yield and Heat Tolerance
Authors: Mudasir Muhammad , Bashir Sadia 
Published: June 2024

Abstract

Heat stress due to climate change could be a critical factor for plant growth as it disturbs flowering time and reduces the crop yield. Therefore, it is crucial to investigate the performance of crop genotypes under heat stress condition. The present research was conducted to assess heat tolerance in 25 mungbean genotypes. The experiment was performed in randomized complete block design on two sowing dates: normal sowing (39°C/26°C) and late sowing for heat treatment (47°C/30°C). All genotypes showed significant variations for treatments, genotypes, and genotypic × treatment interactions. Significantly positive correlation of plant height (0.73**, 0.44**), number of seeds per pod (0.74**, 0.45**) and 100-seed weight (0.89**, 0.43**) with seed yield was recorded under both control and stress conditions, respectively. Principal component analysis revealed a high contribution of seed yield, yield index, geometric mean productivity, tolerance, stress tolerance index and mean productivity for PC1 and PC2. Cluster analysis revealed that genotypes retained in cluster 1 and 2 could be utilized to combine yield and stress stability indices in breeding programs. Findings from multivariate analysis suggested that MN-98, MN-108, MN-2011, MN-2225, MN-93 and MN-203 are potential cultivars under heat stress. Hence, these genotypes could be used as genetic resources for transferring heat tolerance to elite genotypes that are sensitive to high temperatures.
Research on the Regional Disparities and Temporal-Spatial Convergence of the Carbon Emission Reduction Maturity in China
Authors: Yi WANG , Shuo FAN 
Published: June 2024

Abstract

To reveal the spatial evolution, regional inequality and convergence characteristics of carbon emission reduction maturity in China, the paper calculates the maturities of carbon emission reduction of 30 provinces from 2006 to 2021, and describes the spatial pattern of its average level by using of Arcgis technique. The Dagum Gini coefficient is used to reveal the regional inequality and its source, and the convergence is empirically tested by σ convergence and β convergence. The research results show that the carbon emission reduction maturity has an overall improvement trend in China, but it has obvious non-equilibrium characteristics. The regional disparities are the main sources of the non-equilibrium which the carbon emission reduction maturity had. The carbon emission reduction maturity in the eastern region has σ convergence, while the carbon emission reduction maturities in other regions show divergence. The carbon emission reduction maturity in China shows obvious temporal-spatio β convergence characteristics, and the maturities of carbon emission reduction in eastern and western regions are similar to the country, while northeast and central regions’ are completely opposite. Finally, in order to improve the carbon emission reduction maturities and effectively narrow the regional inequality, the paper puts forward policy suggestions from three aspects: high-quality development, scientific and technological innovation and complementary integration.
Degradation of Cefixime Antibiotic by Heterogeneous Catalytic Ozonation Process using novel LDH/zeolite nano-composite:Modeling and Optimization Process
Authors: Sheikh Yalda , Tazikeh-Lemeski Elham , Shahamat Yousef Dadban , Baei Mohammad Taghi , Jalilian Hamidreza 
Published: June 2024

Abstract

In recent decades, the indiscriminate use of antibiotics and their discharge into the environment have caused serious consequences for aquatic and terrestrial organisms. In the present study, the optimization of cefixime antibiotic decomposition by a powerful catalytic ozonation process has been investigated. In this study, MgAl-LDH /zeolite nanocomposite was synthesized and use as an ozonation-adsorption catalyst for the degradation of Cefixime antibiotic from aqueous solution. XRD, FE-SEM, and FTIR analyzes were scrutinized to reveal the main characteristics of the as-prepared nanocomposite, showing that it was well-synthesized. The investigated variables in the catalytic ozonation of Cefixime by the mentioned nanocomposite included solution pH level (5–9), nanocatalyst dose (0.5–2.5 g/L), Cefixime concentration (5–25 mg/L) and reaction time (5–60 min) which they were optimized by adopting RSM-CCD. The results showred that all variables had a positive effect on the efficiency of the catalytic ozonation process. Nonetheless, the lowest effect of operational factor pH, the degradation of Cefixime was subjected to the initial content of Cefixime in this treatment system. The optimal conditions for cefixime removal by catalytic ozonation process were determined at pH of 7.72, nanocatalyst dosage of 1 g/L, cefixime concentration of 23 mg/L, and reaction time of 55 min. In the optimized operating conditions, the removal efficiency of Cefixime by MgAl-LDH /zeolite nanocomposite was high up to 98.37%.
Causal associations of Graves’ Disease with hepatobiliary carcinoma in East Asian population: a Mendelian randomization study
Authors: Li Xueliang , Sun Zhaowei , Wang Qinlei , Wang Maobing , Cao Guanghua , Yu Yanan , Zhong Haochen , Ma Kai , Zhang Bingyuan , Feng Yujie 
Published: June 2024

Abstract

Background
Graves' disease, a thyroid autoimmune disease, has been shown to be associated with a variety of cancers, whereas the association of the disease with hepatobiliary carcinoma (HC) remains unexplored. In this research, we systematically analyze causal links of Graves’ Disease (GD) with HC by means of a Mendelian randomization (MR).
Methods
In this study, we utilize five methods such as MR-Egger, Inverse variance weighting (IVW), Weighted median, Simple mode and Weighted mode to explore the connection between the exposure factor and the outcome variable. Then we observe the sensitivity, heterogeneity and multiple effects between causes and effects by applying Cochran's Q-test, leave-one-out analysis and MR Egger intercept test. We carried out forward MR analysis which employed GD as the risk factor, and HCC (hepatocellular carcinoma) and BTC (biliary tract cancer) as the outcome variables. Then the reverse MR analysis we carried out was the opposite.
Results
The IVW approach in the forward MR analysis pointed that there has a possible relationship between GD and BTC (IVW: OR = 0.83, 95% CI: 0.729–0.945, p = 0.005), while the study also pointed that GD may be causally related to HCC (IVW: OR = 0.882, 95% CI: 0.799–0.974, p = 0.013). Subsequent MR Egger regression analyses conducted noted no significant multicollinearity between instrumental variables (IV) (BTC: Egger intercept = 0.041, p = 0.221; HCC: Egger intercept = -0.028, p = 0.793): Egger intercept = -0.028, p = 0.793). Our sensitivity analysis which use leave-one-out analysis pointed that culling any of the 29 single nucleotide polymorphisms (SNPs) in the GD did not obviously reverse the outcomes, indicating that there was no significant heterogeneity in this analysis.
Conclusion
GD may be a protective factor for HC, and these discovers inspirit us to carry out clinical studies between GD and HC.