bluuebunny/crossref_metadata_2025_split huggingface dataset:
Outcomes of Vitreoretinal Surgery in Patients with Closed-Globe Injury
Authors: Erdurman Cuneyt F. , Ceylan Melih O. , Acikel Cengiz Han , Durukan Hakan A. , Mumcuoglu Tarkan 
Published: October 2010

Purpose TO evaluate the clinical features, visual outcomes, and prognostic factors in patients who underwent vitreoretinal surgery after closed-globe injury. Methods Retrospective review of patients with closed-globe injuries who underwent vitreoretinal surgery between January 2003 and December 2007. Results The study cohort included 46 eyes from 46 patients who underwent vitreoretinal surgery for posterior segment injury. Retinal detachment was the most frequent indication for the surgery, in 33 eyes (72%). After surgery, final visual acuity of 20/400 or better was achieved in 35 eyes (76%), while 11 eyes (24%) had visual acuity less than 20/400 (poor visual outcome). The most frequent reason for poor outcome was proliferative vitreoretinopathy (PVR) (6 eyes), followed by macular complications (3 eyes) and optic atrophy (2 eyes). Two cases with PVR became phthisical following repeated vitreoretinal procedures and also lost light perception. Prognostic factors associated with poor outcomes included delayed presentation, presenting visual acuity of less than 20/400, the presence of initial macular detachment, and the need for additional surgical intervention (p<0.05). No statistical difference was found in final visual acuity between eyes with or without retinal detachment (p>0.05). Also, the presence of damage to the anterior segment was not significantly associated with poor visual outcome (p>0.05). Conclusions In patients with posterior segment pathology caused by closed-globe trauma, retinal detachment was the most common reason for vitreoretinal surgery and PVR was the main cause of surgical failure. The poor visual outcomes associated with delayed presentation suggest that patients need to be referred for further management.
Conventional Surgery for Complicated Retinal Detachment in Silicone Oil-Filled Eyes
Authors: Acar Mehmet A. , Ünlü Nurten , Hazirolan Dicle , Demir M. Necati , Üney Güner Ö. , Örnek Firdevs 
Published: October 2010

Purpose TO evaluate the anatomic and functional outcomes of conventional surgery in silicone oil (SO)-filled eyes with complicated retinal detachment (RD). Methods The records of patients who underwent scleral buckling surgery for complex RD in SO-filled eyes were retrospectively reviewed. Conventional RD surgery involved a 2.5-mm encircling band, 6-mm silicone strip for the inferior quadrants or local sponge implant, subretinal fluid (SRF) drainage, and/or SO aspiration with a 27-G needle. Cryotherapy and/or laser photocoagulation was applied around the tears and 360° of the peripheral retina. Results In all, 4 of the cases had retinal breaks in the lower quadrants, 1 of which had a macular hole; recurrence was due to proliferative vitreoretinopathy (PVR) in the 3 other cases. Three cases were treated with external SRF drainage, 3 cases with SO aspiration, and 1 case with both external drainage and SO aspiration. The retina was attached at the last follow-up visit in 6 (85.7%) of the 7 eyes. One of the cases required secondary vitreoretinal surgery for recurrent RD due to PVR and still had SO tamponade at last follow-up visit. Mean follow-up period was 17.28 ± 8.64 months. Mean logMAR visual acuity was 1.47 ± 0.47 preoperatively and 1.4 ± 0.97 postoperatively. Conclusions Inferior RD in eyes treated with silicone oil tamponade, with or without a retinal break, can be treated with scleral buckling surgery, external SRF drainage, and/or pars plana SO aspiration with satisfactory functional and anatomic outcomes in selected complicated RD cases.
As-Needed Treatment with Ranibizumab 0.5 mg in Patients with Neovascular Age-Related Macular Degeneration
Authors: Biarnés Marc , Monés Jordi , Villalbi Joan R. , Arias Lluís 
Published: October 2010

Purpose TO describe the results obtained in patients with neovascular age-related macular degeneration treated with ranibizumab 0.5 mg on an as-needed basis from the start after 1 year of follow-up. Methods Retrospective, consecutive interventional case series of patients with all angiographic types of neovascular age-related macular degeneration (mean baseline size, 3.4 disk areas) in a tertiary retinal center (Institut de la Màcula i la Retina; Barcelona, Spain). Main outcome was mean vision change; secondary outcomes were center retinal thickness change, number of injections, adverse events, and independent covariates associated with a good response. Results Mean visual acuity change was an increase of 1.3 letters (95% confidence interval −2.7 to +5.3), and difference between angiographic patterns did not reach statistical significance (p=0.30). A decrease in retinal thickness of 44.6 μm was identified (p<0.001), with a median of 3 injections. Absence of baseline arterial hypertension, lower visual acuity, and lesions located outside the fovea were associated with a better response to therapy. Conclusions As-needed treatment from the start achieved stabilization of visual acuity and a moderate decrease of retinal thickness with a low number of injections, but did not achieve the same efficacy as regular monthly injections.
Comparing Applanation Tonometry and Rebound Tonometry in Glaucomatous and Ocular Hypertensive Eyes
Authors: Marini Marino , Da Pozzo Stefano , Accardo Agostino , Canziani Tiziana 
Published: October 2010

Purpose TO describe Goldmann applanation tonometer (GAT) and rebound tonometer (RT) agreement in measuring intraocular pressure (IOP) in glaucomatous and ocular hypertensive (OH) eyes and to evaluate central corneal thickness (CCT) influence on RT readings. Methods A total of 347 eyes were enrolled and IOP measured between 9 and 11 am. Rebound tonometry was performed first (RT1), followed by 3 consecutive GAT measurements and by a second RT reading (RT2), within a 5-minute span. Mean IOP (±SD) values were compared by means of paired t-test. Agreement between GAT and RT1 (test 1) and RT2 (test 2) was evaluated with Bland-Altman method, whereas a linear function described the relationship between CCT and IOP taken with RT. Results Mean IOP (±SD) taken with RT1, GAT, and RT2 was 18.1±4.3, 15.6±3.3, and 16.3±3.9 mmHg, respectively. Readings were within ±3 mmHg in 63.7% and 86.7% of eyes for test 1 and 2, respectively. A significant (p<0.001) proportional bias was noted on both tests (95% limits of agreement: −2.3/7.4 and −3.6/5.0 mmHg for test 1 and 2, respectively). Agreement between instruments decreased for increasing IOP. Rebound tonometry readings increased by 4.6 and 4.1 mmHg for RT1 and RT2, respectively, for each 100–μm CCT increase. Conclusions When used first, RT significantly overestimated IOP compared with GAT. Differences became clinically negligible when RT was used immediately after GAT. Repeated applanation tonometry may explain this observation. Agreement between instruments was acceptable for low IOP, but worsened with increasing IOP values. RT is significantly influenced by CCT. Goldmann applanation tonometer and RT should not be used interchangeably.
Trisomy 1q42-qter Associated with Monosomy 6q27-qter: A Case Report
Authors: Tartaglia Edoardo , Mastrantonio Pasquale , Costa Davide , Giugliano Brunella , Porcellini Antonio , Costagliola Ciro 
Published: October 2010

Purpose Partial trisomy 1q42-qter is a rare chromosomal aberration. Most cases arise from de novo unbalanced translocations or from unbalanced inheritance of parental balanced rearrangements. Methods Descriptive case report. Results A 4-year-old boy had shown an increased neck translucency at the fetal ultrasound examination performed at the 11th week of gestation. Amniocentesis, performed at the 18th week of gestation, did not demonstrate any genetic abnormality. A second fetal ultrasound examination, carried out at the 35th week of gestation, showed congenital clubfeet and hydrocephalus. At birth, clinical examination revealed congenital bilateral ventriculomegaly bilateral congenital equinovarus clubfeet, low-set ears, plagiocephaly micrognathia, hypertelorism, prominent forehead, broad nasal bridge, hypertonic syndrome, and inguinal hernia. Ophthalmologic consultation showed the presence of optic pit in his left eye. Genetic counseling was performed. Chromosome analysis demonstrated a partial trisomy 1 q42.2-qter associated with a partial monosomy 6q27-qter. Moreover, deletions of the distal region on the long arm of chromosome 6 are frequently associated with both ocular abnormalities and several solid tumor types. Moderate mental and psychomotor retardation has occurred. Conclusions This case emphasizes the importance of scheduling a screening test for eye diseases and tumor in these patients.
Vitrectomy for Vitreous Opacities and Macular Pucker in Gaucher Disease
Authors: Rapizzi Emilio , Vannozzi Lorenzo , Borgioli Vanni , Giansanti Fabrizio , Murro Vittoria , Sodi Andrea , Menchini Ugo 
Published: October 2010

Purpose TO report significant surgical results in an uncommon ophthalmologic complication of a rare disease. Methods Interventional case report. Results A 16-year-old girl with type III Gaucher disease experienced visual loss in both eyes. Ophthalmologic examination revealed dense whitish vitreous opacities and macular pucker OU. Visual acuity (VA) OD was 20/63 and OS was 20/25. She underwent 25-gauge vitrectomy with removal of the vitreous core, posterior vitreous cortex, and indocyanine green-stained internal limiting membrane OD. Visual acuity improved, reaching 20/25 1 year after surgery despite the appearance of small preretinal flecks. Visual acuity OS decreased some time later and vitrectomy was performed when VA OS was 20/100. Three years after surgery, BCVA was 20/25 OD and 20/20 OS 1 year after surgery. Conclusions We describe a young patient with Gaucher disease with severe bilateral vitreous opacities and macular pucker. After surgery, vitreous opacities partially and progressively recurred, but the overall favorable outcome strongly supports a surgical approach in cases of this kind.
Surgical Reposition of a Dislocated Ex-PRESS Miniature Device
Authors: Vetrugno Michele , Ferreri Paolo , Cardascia Nicola , Sborgia Carlo 
Published: October 2010

Purpose TO present a technique of surgical reposition of the Ex-PRESS miniature glaucoma device when dislocated in corneal limbus. Methods A 54-year-old woman diagnosed with glaucoma, with a 3-month history of Ex-PRESS miniature implant, was referred to our department because of progressive intraocular pressure (IOP) rise. Slit-lamp biomicroscopy showed the posterior flange of the implant located in the corneal limbus; IOP was 34 mmHg. Surgical technique consisted of reopening of the conjunctiva and the scleral flap, excision of the corneal tissue covering the flange, and stitching the implant to the sclera with polyprolene suture. Results Postoperatively, IOP rapidly reduced to 5 mmHg and was balanced to 10 mmHg in the follow-up. Conclusions Corneal dislocation of the Ex-PRESS implant, when associated with ocular hypertension, needs surgical treatment. Before considering a trabeculectomy, it could be valuable to attempt an implant reposition.
Intravitreal Bevacizumab in a Patient with a Macular Star in Malignant Hypertension
Authors: Zucchiatti llaria , lacono Pierluigi , Parodi Mauhzio Battaglia , Cascavilla Maria Lucia , Kontadakis Dimitris Stelios , Bandello Francesco 
Published: October 2010

Purpose TO report a case of retinopathy secondary to malignant hypertension showing a macular star, which responded favorably to a single intravitreal injection of bevacizumab (IVB). Methods A 46-year-old man with malignant hypertension showing incomplete macular star in his right eye with best-corrected visual acuity (BCVA) of 20/32 underwent IVB. Results Subsequent examinations revealed a progressive resolution of the macular star with functional recovery over the follow-up. In particular, at the 9-month examination BCVA was 20/20, fundus biomicroscopy disclosed resolution of the macular star, and the retinal sensitivity improved remarkably. Conclusions Intravitreal injection of bevacizumab can be a useful approach to treat the exudative manifestations of malignant hypertension.
Analysis of the Diurnal Intraocular Pressure Profile Pre and Post Trabeculectomy using 24-Hour Monitoring of Intraocular Pressure
Authors: Ross Adam H. , Jackson Thomas E. , Wertheim Michael S. , Spry Paul G.D. , Sparrow John M. , Diamond Jeremy P. 
Published: October 2010

Purpose TO compare the diurnal intraocular pressure (IOP) profile pre and post trabeculectomy with a control group of medically controlled patients. We compared the change in mean, peak, and diurnal IOP fluctuation. Methods This was an observational study of patients at the Bristol Eye Hospital, United Kingdom. All patients underwent initial and subsequent phasing, with surgery between for cases. The unpaired Student t test compared the changes (initial - subsequent) in mean, peak, and fluctuation between cases and controls. Results Fifteen eyes underwent trabeculectomy surgery while the control group contained 17 eyes controlled on topical medical treatment. There was a statistically significant reduction in both mean IOP of 3.7 mmHg (p=0.002) and peak IOP of 4.4 mmHg (p=0.025) in the surgical group compared to the medical group. There was no statistically significant change in the IOP fluctuation between the 2 study groups (p=0.296). Conclusions There is a significant reduction in mean IOP and peak IOP following trabeculectomy. We showed no statistically significant change in the diurnal fluctuation of IOP following trabeculectomy.
Intravitreal Injection of Bevacizumab Induces Inflammatory Alterations in a Uveitis Experimental Model
Authors: Johnsen-Soriano Siv , Arnal Emma , Sancho-Tello Maria , Muriach María , Almansa Inmaculada , Bosch-Morell Francisco , Navea Amparo , Romero Francisco J. 
Published: October 2010

Purpose Bevacizumab is currently used as an intravitreal agent in the treatment of inflammatory-associated eye diseases. The aim of the current study is to explore the effects of the intravitreal injection of bevacizumab on aqueous humour cytokines and chemokines in an experimental uveitis model. Methods Endotoxin-induced uveitis was induced in rats by footpad injections. Bevacizumab was administered by intravitreal injection (75 μg in 3–μL samples) and different chemokine and cytokine proteins were quantified in aqueous humor. Results Intravitreal administration of bevacizumab led to a several-fold increase of RANTES, MCP-1, and IFN-γ concentrations in aqueous humor of endotoxin-treated rats. Conclusions Given the exacerbating effect of bevacizumab on inflammation agents and considering the increasing use of bevacizumab as an off-label intravitreal agent, care should be taken if an underlying inflammatory disease is present.
An Ultrasound Biomicroscopy Study of Filtering Blebs after Deep Sclerectomy with a New Acrylic Implant
Authors: Cabrejas Laura , Rebolleda Gema , Muñoz-Negrete Francisco José , Losada Diego 
Published: October 2010

Purpose TO identify the clinical and anatomic characteristics of filtering blebs after nonpenetrating deep sclerectomy (NPDS) using ultrasound biomicroscopy, and to evaluate its influence on intraocular pressure (IOP) control. Methods We conducted a prospective interventional case series in 18 eyes of 18 patients who had undergone nonpenetrating deep sclerectomy with Esnoper® implant. A complete ophthalmic examination and ultrasound biomicroscopy (UBM) exploration were performed at 1, 3, and 6 months postoperatively. Results Intraocular pressure significantly decreased from a mean of 23.5 mmHg (SD 3.5) preoperatively to a mean of 13.1 mmHg (SD 7.6), 13.2 mmHg (SD 4.3), and 13.3 mmHg (SD 3) at 1, 3, and 6 months postoperatively, respectively. At 6 months, lower IOP levels significantly correlated with hyporeflective blebs (r=-0.82, p=0.000), with the presence of hyporeflective suprachoroidal space (r=-0.67, p=0.003) and with the presence of hyporeflective area around the scleral lake (r=-0.55, p=0.02). The presence of these 3 filtration signs together correlated with lower IOP levels compared with the presence of only 1 or 2 (p=0.000, p=0.004, p=0.0005) at 1, 3, and 6 months postoperatively, respectively. A thinner trabeculodescemetic membrane (TDM) was significantly correlated with lower postoperative IOP value at the first postoperative month (r=0.45, p=0.05). Intraocular pressure mean values and UBM characteristics were not significantly different between eyes with single NPDS and eyes following combined NPDS-phacoemulsification. At 6 months, eyes without goniopuncture had lower IOP values (p=0.02), higher bleb (p=0.015), and thinner TDM (p=0.01) than those needing goniopuncture. Conclusions Ultrasound biomicroscopy is a useful method to evaluate outflow mechanisms after NPDS and their correlation with postoperative IOP control.
Nerve Fiber Layer and Macular Thinning Measured with Different Imaging Methods during the Course of Acute Optic Neuritis
Authors: Garas Anita , Simó Magdolna , Holló Gábor 
Published: October 2010

Purpose TO compare retinal nerve fiber layer thickness (RNFLT) and inner macula thickness changes measured with Fourier-domain optical coherence tomography (FD-OCT) and scanning laser polarimetry during the course of acute optic neuritis (ON). Methods Nine eyes of 7 consecutive patients with multiple sclerosis (MS) were prospectively imaged from the onset of ON for 6 to 12 months. Nine healthy eyes were imaged for 12 to 19 months. Results Retinal nerve fiber layer thickness measured with FD-OCT initially increased in all eyes with diffuse optic disc edema. Inner macula thickness and Polarimetric RNFLT decreased already in the acute phase, in all eyes. All parameters stabilized at 2 to 5 months. The relative structural loss was different with the different Methods. Poor image quality with polarimetry occurred in 2 eyes in the acute phase of ON. In the control eyes all parameters were stable. Conclusions Change of RNFLT and macular thickness during the course of acute ON in MS strongly depends on the method used for the measurement. Inner macula thickness, measured with FD-OCT, was especially useful for the follow-up, since it was not influenced by initial disc edema and had consistently high image quality.
3D Spectral Domain Optical Coherence Tomography Findings in Choroidal Tumors
Authors: Sayanagi Kaori , Pelayes David E. , Kaiser Peter K. , Singh Arun D. 
Published: October 2010

Purpose TO report the optical coherence tomographic features differentiating choroidal nevus from choroidal melanoma by 3D spectral-domain optical coherence tomography (SD-OCT) and OCT characteristics of other choroidal tumors. Methods A total of 67 consecutive eyes with choroidal tumors including choroidal nevus (25 eyes), indeterminate choroidal melanocytic lesion (11 eyes), malignant melanoma (23 eyes), metastasis (4 eyes), hemangioma (2 eyes), and osteoma (2 eyes) were imaged with 3D SD-OCT (OCT-1000; Topcon Inc., Paramus, NJ). The images were analyzed for the presence or absence of SD-OCT findings such as retinal pigment epithelium (RPE)/choriocapillaris reflectivity, RPE irregularity, drusen, sub-RPE fluid, RPE thickness, subretinal deposit, subretinal fluid, intraretinal edema, retinal thickness, and photoreceptor inner and outer segment junction (IS/OS). Visualization of the choroidal tumor and its intrinsic reflectivity OCT features were also assessed. Results When compared with nevus, subretinal deposit, subretinal fluid, and intraretinal edema were detected significantly more frequently in the eyes with malignant melanoma (p<0.001). SD-OCT visualization of the tumor was limited only to the anterior aspect. Choroidal nevus, indeterminate lesions, melanoma, and metastatic lesions had variable intrinsic reflectivity pattern. Intrinsic features of hemangioma included choroidal hollowness whereas osteoma demonstrated high intrinsic reflectivity. Conclusions SD-OCT provides useful information to observe and document the retinal and RPE changes secondary to choroidal tumors that help differentiate choroidal nevus from malignant melanoma. Improvements in the current OCT systems are needed to better characterize intrinsic features of choroidal tumors.
Acoustic vibrations in free‐standing single‐, bi‐layer nanomembranes and patterned wires
Authors: Bandhu R.S. , Sooryakumar R. , Bussmann K. 
Published: November 2010

AbstractBrillouin light scattering investigations of acoustic vibrations in freestanding membranes, soft‐hard bi‐layers and patterned wires are described. Studies of longitudinal and transverse standing wave resonances, the wave vector dependence of surface and guided waves as well as their hybridization with flexural and dilational waves are presented. Size effects and the role of reduced dimensions on the acoustic behavior are investigated in soft rectangular polymeric wires on freestanding silicon nitride membranes. The mode frequencies and amplitudes are analyzed in terms of surface Green's functions and the xyz algorithm.
Optical properties of nitride nanostructures
Authors: Cantarero A. , Cros A. , Garro N. , Gómez‐Gómez M.I. , García A. , de Lima M.M. , Daudin B. , Rizzi A. , Denker C. , Malindretos J. 
Published: November 2010

AbstractIn this paper we review some recent results on the optical properties of nitride nanostructures, in particular on GaN quantum dots (QDs) and InN nanocolumns (NCs). First, we will give a brief introduction on the particularities of vibrational modes of wurtzite. The GaN QDs, embedded in AlN, were grown by molecular beam epitaxy (MBE) in the Stransky‐Krastanov mode on c‐ and a‐plane 6H‐SiC. We have studied the optical properties by means of photoluminescence (PL) and performed Raman scattering measurements to analyze the strain relaxation in the dots and the barrier, the effect of the internal electric fields, and the influence of specific growth parameters, like the influence of capping or the spacer on the relaxation of the QDs. A theoretical model, based on continuous elastic theory, were developed to interpret the Raman scattering results. On the other hand, InN NCs have been grown by MBE in the vapor‐liquid‐solid mode using Au as a catalyst. The nanocolumns have different morphology depending on the growth conditions. The optical properties can be correlated to the morphology of the samples and the best growth conditions can be selected. We observe, from the analysis of the Raman data in InN NCs, the existence of two space regions contributing to the scattering: the surface and the inner region. From the inner region, uncoupled phonon modes are clearly observed, showing the high crystal quality and the complete relaxation of the NCs (no strain). The observation of a LO‐phonon‐plasmon couple in the same spectra is a fingerprint of the accumulation layer predicted at the surface of the nanocolumns.
Alkynic fatty acids: ω‐Arylation, methoxycarbonylation to α,β‐unsaturated esters, cyclotrimerization to pyridines and 2‐pyridones
Authors: Augustin Kim E. , Schäfer Hans J. 
Published: November 2010

AbstractDehydrogenation of double to triple bonds by bromination/dehydrobromination and triple bond isomerization by the alkyne zipper reaction provide a short and facile access to internal and terminal alkynic fatty acids. Thereby methyl 10‐undecynoate, methyl 9‐octadecynoate, methyl 17‐octadecynoate and derivatives have been prepared from the corresponding alkenic fatty acids. Their conversions are reported: The hydrogen in the terminal alkynic fatty compounds is substituted in a ω‐carboxylation and a palladium(0)‐catalysed ω‐arylation. With carbon monoxide/methanol internal α,β‐unsaturated monoesters and terminal unsaturated diesters are obtained under mild conditions by palladium(II)‐catalysis. Furthermore dimer fatty acids with a pyridine and a 2‐pyridone core are prepared by cyclotrimerizations of alkynic fatty compounds with alkylnitriles and N‐phenylisocyanate.