bluuebunny/crossref_metadata_2025_split huggingface dataset:
Photodynamic metabolite-powered zero-waste “ferroptosis amplifier” for enhanced hypertrophic scar therapy
Authors: Chen Tao , Chen Yuan , Wang Shan , Mao Xiu , Wen Yao , Zhu Xingyu , Fan Dongqi , Liu Ping , Chen Xu , Zhan Lei , Ma Xi , Yang Xin , He Qingqing , Ji Ping 
Published: June 2024

Abstract

Hypertrophic scar (HS) is a somatopsychic disease that significantly affects quality of life. 5-aminolevulinic acid (5-ALA)-mediated photodynamic therapy (PDT) shows promise for HS treatment, while challenges like poor transdermal delivery and the accumulation of photodynamic by-products restrict its effectiveness. Inspired by the natural phenomenon that a whale fall brings life to thousands, this study proposes a zero-waste strategy by leveraging the photodynamic metabolite heme to establish a “ferroptosis amplifier”, which allows these metabolic wastes to be transformed into new sources of energy, thereby amplifying ferroptosis response following PDT. This is achieved by encapsulating 5-ALA and baicalin within human H-ferritin (HFn), subsequently incorporated into polyvinylpyrrolidone (PVP) microneedles (FAB@MN). The FAB@MN exhibits excellent targeting towards hypertrophic scar fibroblasts (HSFs) and pH-responsive programmed drug release. The treatment begins with the release of 5-ALA, which is converted into PpIX to activate PDT. Baicalin is then released, which directly triggers ferroptosis while also facilitating the breakdown of photodynamic waste heme into Fe2+ and CO, thereby amplifying ferroptosis. Unlike conventional PDT only focuses on immediate effects, this approach uses photodynamic waste to fuel a sustained ferroptosis response after PDT, offering a new path for treatment.
First molecular diagnosis of Oestrus ovis (Linnaeus, 1758) larvae causing conjunctival ophthalmomyiasis in Mexico City, Mexico
Authors: Olivera-Pérez Carolina Isabel , Lagunas-Calvo Omar , Cortés-González Vianney , Oceguera-Figueroa Alejandro , García-Prieto Luis , Peña-Ortíz Samuel , Hernández-Piñamora Luis Alfonso , Reyna-Fabián Miriam Erandi 
Published: June 2024

Abstract

Purpose
Human ophthalmomyiasis is a rare ocular parasitosis that results from the accidental infestation of dipteran larvae of several species, including Oestrus ovis (Linnaeus, 1758). This study aims to present the fourth documented human case of ophthalmomyiasis in Mexico, identifying the etiological agent through morphological and molecular analyses. Additionally, we investigated the phylogenetic position and genetic distances among different individuals globally characterized based on mitochondrial Cox1 sequences.
Methods
A total of five larval specimens were extracted from the patient's eye, with two specimens allocated for taxonomic identification and the remaining three preserved in absolute ethanol for subsequent DNA extraction. The Cox1 region was amplified and sequenced using automated Sanger sequencing. The resulting sequence was deposited in GenBank under accession number OR440699 and subjected to BlastN analysis against 35 other Cox1 sequences of O. ovis from GenBank. The identity and phylogenetic position of the strains were further explored using parsimony and maximum likelihood phylogenetic methods.
Results
Morphological examination of the larval specimens extracted from the patient's eye unequivocally identified them as O. ovis species. BlastN analysis and comprehensive phylogenetic investigations involving a total of 36 Cox1 sequences confirmed the taxonomic identity of the larvae. Notably, our sequence was positioned within the cluster formed by the Brazilian and two Iranian samples. This finding underscores a shared genetic ancestry among these distinct geographical isolates and provides valuable insights into the evolutionary relationships within O. ovis populations.
Conclusion
The presence of O. ovis infestation in Mexico City suggests potential shifts in environmental conditions favoring fly proliferation, highlighting the need for vigilance in urban healthcare settings.
Synthesis of corn straw based carbon doped Nb 2 O 5 as photocatalysts for Rhodamine B degradation under visible light illumination
Authors: Ding Shuang , Zeng Xu , Wang Bo , Yan Yalan , Ren Bo , Li Yan , Yang Xiaodong 
Published: June 2024

Abstract

Developing efficient visible light photocatalytic materials has always been a challenge for researchers. We have successfully prepared a series of corn straw based carbon doped Nb2O5 with excellent photocatalytic performance under visible light. A series of characterizations were carried out on the synthesized materials, including power X-Ray diffraction(XRD), scan electron miscopy (SEM), nitrogen adsorption, infrared spectroscopy(IR), UV-vis diffuse reflectance spectra, X-ray photoelectron spectroscopy(XPS). The photocatalytic performance of the synthesized samples was investigated under visible light irradiation using Rhodamine B as the degradation target. The experimental results show that the introduction of carbon element has a certain impact on the morphology, specific surface area, pore size distribution, elemental composition, functional groups, and visible light absorption of the sample, which in turn has a significant impact on its photocatalytic performance.This article is of great significance for the application of biomass materials and the improvement of environmental quality, and also provides new ideas for the design and synthesis of new composite functional materials.
Effect of Phenylephrine versus Ephedrine on Postoperative Delirium in Elderly Patients Undergoing Knee Arthroplasty General Anaesthesia：A Single-Center Trial
Authors: Zheng Changjian , Wang Bin , Fu Jiuzhou , Peng Hui , Chen Yongquan , Hu Xianwen 
Published: June 2024

Abstract

Despite equalizing blood pressure(BP), ephedrine and phenylephrine exhibit distinct impacts on rSO2. However, whether this heterogeneity in rSO2 affects the occurrence of POD remains understudied. This study aimed to explore the effects of maintaining BP with ephedrine versus phenylephrine on the incidence of POD in elderly patients undergoing knee arthroplasty under general anesthesia. A total of 120 patients aged 60-90 years undergoing knee arthroplasty were included in this study.The patients were randomly divided into two groups: the ephedrine group and the phenylephrine group. After anesthesia induction, continuous infusion of the respective medication was initiated to maintain intraoperative mean arterial pressure within the normal range (baseline mean arterial pressure ± 20%).The primary outcome measures included the incidence of POD within 1-3 days after the surgery. The incidence of POD on the first day after surgery was lower in the ephedrine group compared to the phenylephrine group (33% vs 7%, P < 0.001 ). However, there was no significant difference in the incidence of POD between the two groups on the second and third postoperative days. During surgery, the ephedrine group exhibited significantly increased CO and rSO2 compared to the phenylephrine group (P < 0.05).
Clinical Trials Registry: ChiCTR2200064849, principal investigator: Changjian Zheng.
Design of an Object Recognition Network Based on YOLOv5s for Lightweight Deep Information Extraction and Fusion of Deep and Shallow Layer Information
Authors: Liu Chang , Wang Guili , Xu Lin , Qu Liguo , Zhang Hangyu , Tian Longlong , Li Chenhao , Sun Liangwang , Zhou Minyu 
Published: June 2024

Abstract

In object detection, targets in adverse and complex scenes often have limited information and difficult feature extraction, necessitating deeper feature extraction to adequately capture target features for accurate localization and classification. Addressing the challenge of object detection in complex scenes and low-quality images, this paper designs a lightweight feature extraction network based on CBAM and multi-scale information fusion. Initially, within the Backbone module of YOLOv5s, we construct large-scale, deep feature maps, integrate CBAM, and fuse high-resolution features from shallow networks with deep features. We also add new output heads, employing different feature extraction structures for classification and localization. These improvements significantly enhance detection performance, particularly in challenging scenarios such as strong light, nighttime, and rainy conditions. Experimental results indicate that the improved network structure demonstrates superior detection performance in complex scenes, especially for pedestrian crossing detection under adverse weather and low-light conditions. The study utilizes an open-source pedestrian crossing dataset from Shanghai Jiao Tong University, available on GitHub. Our algorithm improves the pedestrian crossing detection precision (AP0.5:0.95) by 5.9%, reaching 82.3%, while maintaining a detection speed of 44.8 FPS, thereby meeting the stringent requirements of real-time detection. The source code for this program can be found at this address https://github.com/soo-s/yolov5-crosswalk/
Efficient photon-pair generation in layer-poled lithium niobate nanophotonic waveguides
Authors: Zhu Di , Shi Xiaodong , Mohanraj Sakthi , Dhyani Veerendra , Baiju Angela , Wang Sihao , Sun Jiapeng , Zhou Lin , Paterova Anna , Leong Victor 
Published: June 2024

Abstract

Integrated photon-pair sources are crucial for scalable photonic quantum systems. Thin-film lithium niobate is a promising platform for on-chip photon-pair generation through spontaneous parametric down-conversion (SPDC). However, the device implementation faces practical challenges. Periodically poled lithium niobate (PPLN), despite enabling flexible quasi-phase matching, suffers from poor fabrication reliability and device repeatability, while conventional modal phase matching (MPM) methods yield limited efficiencies due to inadequate mode overlaps. Here, we introduce a layer-poled lithium niobate (LPLN) nanophotonic waveguide for efficient photon-pair generation. It leverages layer-wise polarity inversion through electrical poling to break spatial symmetry and significantly enhance nonlinear interactions for MPM, achieving a notable normalized second-harmonic generation (SHG) conversion efficiency of 4615% W-1 cm-2. Through a cascaded SHG and SPDC process, we demonstrate photon-pair generation with a normalized brightness of 3.1×106 Hz nm-1 mW-2 in a 3.3 mm long LPLN waveguide, surpassing existing on-chip sources under similar operating configurations. Crucially, our LPLN waveguides offer enhanced fabrication reliability and reduced sensitivity to geometric variations and temperature fluctuations compared to PPLN devices. We expect LPLN to become a promising solution for on-chip nonlinear wavelength conversion and non-classical light generation, with immediate applications in quantum communication, networking, and on-chip photonic quantum information processing.
The incidence of symptomatic CSF viral escape in patients on antiretroviral therapy in western India: a retrospective cohort study
Authors: Patel Atul , Patel Ketan , Patel Niyati , Shah Kinjal , Kumar Ambuj 
Published: June 2024

Abstract

Antiretroviral treatment (ART) effectively suppresses viral loads in both plasma and cerebrospinal fluid (CSF). Patients with discordant plasma and CSF viral loads may experience chronic-progressive or fluctuating neurocognitive dysfunctions. This study examined at the incidence of symptomatic CSF viral escape (CSFVE) in patients receiving ART. This retrospective cohort study was conducted between 2000 and 2023. The primary outcome measure was the incidence of symptomatic CSFVE. Nonparametric Mann-Whitney U and Fisher exact/χ 2 tests were applied for continuous and categorical variables, respectively. The cumulative incidence function with Gray's test was used to compare the incidence of CSFVE across the treatment regimens. During the study period, 52 of the 8415 patients were diagnosed with CSFVE. The median duration of HIV diagnosis in patients with CSF VE was 150 (12–288) months, with a median nadir CD4+ T-cell count (96.5 (13-601 cells/L)], and 75% of the patients were on a ritonavir-boosted protease inhibitor (PI/r) regimen. The cumulative incidence of symptomatic CSFVE at a follow-up of 14 years was 1% (95% CI, 0–1%). PI/r (HR 34.73; 95% CI 13.5 to 89.4; p<0.001) and integrase strand transfer inhibitor (INSTI) (HR 3.42; 95% CI 1.94 to 6.02; p<0.001) regimens were significantly more likely to be associated with CSFVE than the Non-nucleoside reverse transcriptase inhibitors (NNRTIs) regimens. NNRTIs had the lowest risk of CSFVE compared to the PI/r and INSTI regimens. A rapid and complete recovery is possible with symptomatic CSFVE if it is diagnosed and treated early.
Thirty‑Day Readmission Rates and Outcomes after hospitalization for Ischemic Colitis. A National Analysis
Authors: Narvaez Sharon I. , Martinez John P. , Kinnucan Jami , Keilin Steven , Vega Kenneth J. , Argueta Pedro Palacios , Nieto Luis M. 
Published: June 2024

Abstract

Background/Aim
Limited data exists on 30-day readmission rates, readmission causes and predictors following Ischemic Colitis (IC). The aim is to identify etiologies for the above using a national database.
Methods
A retrospective cohort study using the 2019 National Readmission Database (NRD) of adult patients with an index admission (IA) for IC from January to November and were readmitted within 30 days of discharge was performed. The primary outcome was readmission of any cause. Secondary outcomes were mortality and resource utilization associated with readmission. Independent risk factors for all-cause readmission were identified using Cox regression analysis.
Results
A total of 6,853 IC patients were identified. Readmission within 30 days occurred in 762 (11%). The primary readmission cause was sepsis. A total of 325 patients died during the IA and additional 30 patients died within 30 days of discharge. Independent predictors of readmission were discharge to short term hospital, a Charlson comorbidity index score ≥ 2 and admission at large size hospital. Having private insurance and undergoing colonoscopy were associated with lower readmission odds. Economic burden of readmission was $12 million in total costs and $51.4 million in total charges.
Conclusion
Among admitted IC patients, 30-day readmission rate was 11% with half of those secondary to sepsis. Undergoing colonoscopy during the IA is associated with 34% less risk of readmission and disposition to other facilities appears associated with increased early readmission risk. Prospective evaluation to confirm these findings along with development of optimal care strategies to reduce readmission post IC episodes are needed.
Eye Pupil Control Analysis
Authors: Mohammadi Parsa , malakouti seyed matin , Suratgar Amirabolfazl , menhaj mohammad bagher 
Published: June 2024

Abstract

The human eye, a pivotal sense organ, plays a crustal role in shaping our perception of the world. Researchers have consistently delved into its functional aspects, reflecting its paramount significance. Comprising intricate components, the human eye collectively orchestrates the intricate symphony of human visual perception. This study primarily focuses on the human pupil—a pivotal component of this sensory apparatus. In this paper, we rigorously investigate the dynamics of the human pupil through a comprehensive linear control analysis. Our approach involves deriving a linearized model based on prior research findings. Subsequently, we apply advanced control analysis techniques to gain deeper insights into its behavior. The obtained results provide valuable contributions to our understanding of the intricate dynamics governing the human pupil. This research sheds light on the complex interplay of factors that govern the behavior of the human pupil, offering insights with potential applications in fields such as ophthalmology, optometry, and human-computer interaction.
Peptide Tritrpticin Interaction onto Chemically Modified Graphene Oxide Paste Electrode
Authors: Ramos Sandra , Jesus Rodrigo Sá , Almeida Erica Cristina , Brasil Maria Carolina Oliveira Arruda , Cilli Eduardo Maffud , Oliveira Alan Santos , Silva Biancardy Lima , Salay Luiz Carlos 
Published: June 2024

Abstract

The simple strategy to prepare Chemically Modified Carbon Paste Electrodes (CPE) by using Graphene Oxide (GO) was made to promote the desired interaction of antimicrobial Peptide Tritrpticin (TRP3) on them. This interaction was chosen considering the important study of biological sensors remarkable by GO and TRP3. The Interaction of CPEGO with TRP3 was characterized by FTIR and Electrochemical Techniques, that employed Cyclic Voltammetry (CV) and Electrochemical Impedance Spectroscopy (EIS). The FTIR reveals some modifications of GO and GOTRP3 samples, with bands identified by functional polar groups and stretching mode C-N. CV results confirmed that GO promoted the interaction of TRP3 on the Carbon Paste Electrode by TRP3 adsorption on its oxidated defects sites with amplification current response. The oxidation peak potential shows a negative shift around 20 mV in the ferricyanide potassium presence, which indicates electron transfer between the GO and TRP3 was facilitated. EIS measurements show the interaction of TRP3 with GO with smaller electron transfer resistance as the almost linear portion of the Nyquist plot in comparison to CPE. The results indicate a Chemically Modified Carbon Paste Electrode with GO and TRP3 interactions is a potential electrode designed for biological sensor or drug delivery applications.
Automatic Open Wikidata Information Extraction from Indonesian Text
Authors: Doxolodeo Kerenza 
Published: June 2024

Abstract

Open Information Extraction can be used to aid NLP pipeline, especially if it is linked to a knowledge graph. This is the first attempt to perform OIE in Indonesian text by leveraging pre-existing massive knowledge graph such as Wikidata. The model were given "easier" dataset sample to classify and "harder" dataset sample to classify based on its predicate's RDFS label. It achieves 70.14% F1 on the easier one and 46.68% F1 on the harder one. We also experimented with a pipeline that extracts triple "from the open", but the model struggles with triple that conveys relationship with two geographical place.
Entomoneis Parikhani sp.nov., a new diatom (Entomoneidaceae, Bacillariophyta) from Aras River (Iran)
Authors: parikhani fatemeh 
Published: June 2024

Abstract

The diatom genus Entomoneis has a species with unique morphology. Entomoneis has a series of unique features such as connecting lines with different shapes, sigmoid raphe on the bilobate keel, different curtains, and multiple girdle bands. Most species belonging to this genus are found in marine and saline habitats. In fact, the genus Entomoneis is an epicalic diatom that is found in streams with high salinity and high electrolyte concentration. To date, no specific type of freshwater has been identified. In this study, a new species of freshwater diatom, Entomoneis Parikhani, is described based on detailed morphological observations using a scanning electron microscope. The studies were conducted in the Ares River in northwest Iran. An unknown taxon belonging to the genus Entomoneis was found in Oltan village of Parsabad city. The Aras River contains freshwater. A special feature of Entomoneis Parikhani is its triple valve. The genus Entomoneis comprises of diatoms with sigmoidal raphe canals and girdle bands. This taxon is similar to Entomoneis annagodhei and Entomoneis tenera, as shown by LM and SEM observations, and there are sufficient morphological differences to separate Entomoneis Parikhani sp. Entomoneis Parikhani sp found in fresh water and similar species found only in salt water. This new species had very small cells, delicate frustules without valve lines, and wide lanceolate valves. In this study, the wide distribution of this taxon in the Aras River and its tributaries has been discussed in terms of water quality variables.
How much and for how long could the annual cost of atmospheric greenhouse gas (CO2e) abatement between 1960 and 2020 through carbon pricing be estimated?
Authors: Casas-Cuestas Michel , Rodríguez Juan Fernando Álvarez 
Published: June 2024

Abstract

This document presents the estimated cost and timing of climate change mitigation through carbon pricing based on anthropogenic greenhouse gas emissions for the period from 1960 to 2020. This was done by constructing a matrix of prices using public databases comparing reported emissions (Andrew, 2021; Friedlingstein et al., 2020) and then formulating greenhouse gas storage scenarios that were formed based on cost-effective prices (Griscom et al., 2017). This allowed the range of feasible prices to be determined according to the COP Chair's estimates of annual investment capacity and the Stern Review on the Economics of Climate Change (Stern, 2006). Consequently, as a contribution to the knowledge of carbon market prices, annual cost scenarios for climate change management were formulated on the basis of historical emissions and a financial model that compensates for investments, including absorption and storage of greenhouse gases CO2e, in terms of time in the range of 13 to 63 years and a cost of 50 billion to 1.2 trillion dollars. In conclusion, it is possible to use carbon markets to mitigate climate change based on the constraints outlined above by means of natural climate solutions.
Exploring the Mechanism of Zhishi-Xiebai-Guizhi Decoction for the Treatment
of Hypoxic Pulmonary Hypertension based on Network Pharmacology and
Experimental Analyses
Authors: Huang Pan , Wang Yuxiang , Liu Chuanchuan , Zhang Qingqing , Ma Yougang , Liu Hong , Wang Xiaobo , Wang Yating , Wei Minmin , Ma Lan 
Published: June 2024

Background:
Hypoxic Pulmonary Hypertension (HPH), a prevalent disease in highland areas, is a
crucial factor in various complex highland diseases with high mortality rates. Zhishi-Xiebai-Guizhi Decoction
(ZXGD), traditional Chinese medicine with a long history of use in treating heart and lung diseases, lacks a
clear understanding of its pharmacological mechanism.

Objective:
This study aimed to investigate the pharmacological effects and mechanisms of ZXGD on HPH.

Methods:
We conducted a network pharmacological prediction analysis and molecular docking to predict the
effects, which were verified through in vivo experiments.

Results:
Network pharmacological analysis revealed 51 active compounds of ZXGD and 701 corresponding
target genes. Additionally, there are 2,116 targets for HPH, 311 drug-disease co-targets, and 17 core-targets.
GO functional annotation analysis revealed that the core targets primarily participate in biological processes
such as apoptosis and cellular response to hypoxia. Furthermore, KEGG pathway enrichment analysis demonstrated
that the core targets are involved in several pathways, including the phosphatidylinositol-3 kinase/protein
kinase B (PI3K/Akt) signaling pathway and Hypoxia Inducible Factor 1 (HIF1) signaling pathway. In vivo
experiments, the continuous administration of ZXGD demonstrated a significant improvement in pulmonary
artery pressure, right heart function, pulmonary vascular remodeling, and pulmonary vascular fibrosis in HPH
rats. Furthermore, ZXGD was found to inhibit the expression of PI3K, Akt, and HIF1α proteins in rat lung tissue.

Conclusion:
In summary, this study confirmed the beneficial effects and mechanism of ZXGD on HPH
through a combination of network pharmacology and in vivo experiments. These findings provided a new insight
for further research on HPH in the field of traditional Chinese medicine.