bluuebunny/crossref_metadata_2025_split huggingface dataset:
Human TMEM30a Promotes Uptake of Antitumor and Bioactive Choline Phospholipids into Mammalian Cells
Authors: Chen Rui , Brady Erin , McIntyre Thomas M. 
Published: February 2011

AbstractAntitumor alkylphospholipids initiate apoptosis in transformed HL-60 and Jurkat cells while sparing their progenitors. 1-O-Alkyl-2-carboxymethyl-sn-glycero-3-phosphocholine (Edelfosine) like other short-chained phospholipids—inflammatory platelet-activating factor (PAF) and apoptotic oxidatively truncated phospholipids—are proposed to have intracellular sites of action, yet a conduit for these choline phospholipids into mammalian cells is undefined. Edelfosine is also accumulated by Saccharomyces cerevisiae in a process requiring the membrane protein Lem3p, and the human genome contains a Lem3p homolog TMEM30a. We show that import of choline phospholipids into S. cerevisiae ΔLem3 is partially reconstituted by human TMEM30a and by Lem3p-TMEM30a chimeras, showing the proteins are orthologous. TMEM30a–GFP chimeras expressed in mammalian cells localized in plasma membranes, as well as internal organelles, and ectopic TMEM30a expression promoted uptake of exogenous choline and ethanolamine phospholipids. Short hairpin RNA knockdown of TMEM30a reduced fluorescent choline phospholipid and [3H]PAF import. This knockdown also reduced mitochondrial depolarization from exogenous Edelfosine or the mitotoxic oxidatively truncated phospholipid azelaoyl phosphatidylcholine, and the knockdown reduced apoptosis in response to these two phospholipids. These results show that extracellular choline phospholipids with short sn-2 residues can have intracellular roles and sites of metabolism because they are transport substrates for a TMEM30a phospholipid import system. Variation in this mechanism could limit sensitivity to short chain choline phospholipids such as Edelfosine, PAF, and proapoptotic phospholipids.
Coronin 1-Mediated Naive T Cell Survival Is Essential for the Development of Autoimmune Encephalomyelitis
Authors: Siegmund Kerstin , Zeis Thomas , Kunz Gabriele , Rolink Ton , Schaeren-Wiemers Nicole , Pieters Jean 
Published: February 2011

AbstractAutoimmune encephalomyelitis is a disease of the CNS that can develop when an initial peripheral inflammatory stimulus is followed by infiltration and reactivation of T lymphocytes in the CNS. We report a crucial role for coronin 1, which is essential for maintenance of the naive T cell pool, for the development of murine experimental autoimmune encephalomyelitis (EAE), a model for multiple sclerosis. In the absence of coronin 1, immunization with myelin oligoglycoprotein (MOG35–55) peptide largely failed to induce EAE symptoms, despite normal mobilization of leukocyte subsets in the blood, as well as effector cytokine expression comparable with wild-type T cells on polyclonal stimulation. Susceptibility of coronin 1-deficient mice to EAE induction was restored by transfer of wild-type CD4+ T cells, suggesting that the observed resistance of coronin 1-deficient mice to EAE development is T cell intrinsic. Importantly, although coronin 1-deficient regulatory T cells (Tregs) showed a suppressor activity comparable with wild-type Tregs, Treg depletion failed to restore EAE development in coronin 1-deficient animals. These results suggest a hitherto unrecognized role of naive T cells in the development of autoimmune encephalomyelitis and reveal coronin 1 as a crucial modulator of EAE induction.
No Association between Variant N-acetyltransferase Genes, Cigarette Smoking and Prostate Cancer Susceptibility Among Men of African Descent
Authors: Kidd La Creis Renee , VanCleave Tiva T. , Doll Mark A. , Srivastava Daya S. , Thacker Brandon , Komolafe Oyeyemi , Pihur Vasyl , Brock Guy N. , Hein David W. 
Published: February 2011

Objective We evaluated the individual and combination effects of NAT1, NAT2 and tobacco smoking in a case-control study of 219 incident prostate cancer (PCa) cases and 555 disease-free men. Methods Allelic discriminations for 15 NAT1 and NAT2 loci were detected in germ-line DNA samples using Taqman polymerase chain reaction (PCR) assays. Single gene, gene-gene and gene-smoking interactions were analyzed using logistic regression models and multi-factor dimensionality reduction (MDR) adjusted for age and subpopulation stratification. MDR involves a rigorous algorithm that has ample statistical power to assess and visualize gene-gene and gene-environment interactions using relatively small samples sizes (i.e., 200 cases and 200 controls). Results Despite the relatively high prevalence of NAT1*10/*10 (40.1%), NAT2 slow (30.6%), and NAT2 very slow acetylator genotypes (10.1%) among our study participants, these putative risk factors did not individually or jointly increase PCa risk among all subjects or a subset analysis restricted to tobacco smokers. Conclusion Our data do not support the use of N-acetyltransferase genetic susceptibilities as PCa risk factors among men of African descent; however, subsequent studies in larger sample populations are needed to confirm this finding.
A Review of Sevelamer Hydrochloride in End-Stage Renal Disease Patients on Dialysis
Authors: Spasovski Goce 
Published: February 2011

It is known that in the presence of even subtle kidney dysfunction an intensive prevention of cardiovascular risk is required. Apart from the conventional factors which contribute to cardiovascular disease (CVD), there are also some specific conditions of the chronic kidney disease (CKD) population such as oxidative stress of uremia and dialysis (D). However, hyperphosphatemia, hypercalcemia, and elevated calcium-phosphorus product remain as major contributors to the development of vascular calcification (VC) in this population, as part of the systemic complication known as mineral and bone disorders (MBD) in CKD patients. Importantly, the retention of phosphate remains as main culprit in the pathogenesis of CKD–-MBD. Over the years, various treatment options for phosphate removal and controlling mineral metabolism, bone health, VC and CVD have failed, mainly through an over-suppression of PTH, development of ABD and promotion of VC and mortality. Although KDOQI and KDIGO published CKD–-MBD guidelines has clearly stated where calcium-based phosphate binders should not be used in D patients (hypercalcemia and low PTH) and where non calcium-containing phosphate binders are preferred (patients with severe vascular and/or other soft tissue calcifications), the greatest controversy and disagreements within the nephrological community still exists upon the cost-effectiveness of non calcium binder (sevelamer) use. Indeed, despite the evidence and recognised trend towards both a decrease in VC and CVD associated with sevelamer use, it is still an ongoing matter of debate. The magnitude of this controversy is increased when the issue of advanced medical and/or budgetary evaluation related to the implementation of clinical guidelines for CKD–-MBD treatment is considered. Despite advocated use of sevelamer across a range of common clinical scenarios in CKD, its widespread utilization is challenged as exceeding what would usually be considered good value for money. If so, it is questionable whether the recommendations and suggestions from the guidelines should be followed, and further, do we need guidelines and innovative drugs for treatment of hyperphosphatemia? While awaiting the answer, as clinicians we should proceed with a treatment to “do no harm”, trying to at least limit the calcium exposure of our dialysis patients.
Exploring the impact of altitude on congenital heart defects in Saudi Arabia
Authors: Sandridge Amy L. , Greer William , Al-Menieir Maha , Al Rowais Abdullah 
Published: February 2011

AbstractCongenital heart defects (CHD) have a complex etiology in which environmental factors play a key role. High altitude has already been established as a risk factor. Data from the CHD Registry in Riyadh were used to explore the impact of altitude throughout the Kingdom, including the mountain ranges of the south-west; 2,787 Saudi Arabian CHD cases were studied from 104 different cities and villages. Altitude was estimated using a geographical information system. The CHD “burden” was estimated by normalizing the number of CHD cases according to the city population. Cities at both the highest and the lowest altitudes displayed an increased CHD burden, indicating that CHD burden in Saudi Arabia is impacted by at least two different environmental factors — high altitude and coastal proximity. There is also an indication of a separate south-western influence which may reflect a unique cultural or genetic factor.
Mechanisms for collaboration and influence: the role of IFLA and other international library-related organizations
Authors: Byrne Alex 
Published: February 2011

Abstract
Collaboration and influence lie at the heart of non-governmental organizations because they are created by people and their organizations which want to achieve some shared goals. Collaboration needs to be fostered at many levels including that among individuals, between member organizations, and with external bodies. Library organizations need to build structures of collaboration to provide a foundation for collaborative action towards shared goals. It is also vital that they understand the need to be influential, to look continually outside their own fields to see who to influence to support their aims.
Developing videocasts for integration into a library information literacy program at a medical college
Authors: Birch Sally , Burnett Alice , Sayed Ellen N. 
Published: February 2011

Abstract
Established in 2001 as a partnership between Cornell University and Qatar Foundation, Weill Cornell Medical College in Qatar (WCMC-Q) is part of Weill Cornell Medical College in New York and shares its mission of dedication to excellence in education, patient care and research.
The Distributed eLibrary (D eLib) at the WCMC-Q is a library without walls, existing in a distributed electronic environment, transcending space and place. One of its key defining features is its disseminated yet interconnected services, resources, and presence that are accessible, flexible, and dynamic.
D eLib’s strategic plan, Futura, charts the future for information resources and services and the library’s role in supporting WCMC-Q’s tripartite mission. It is a challenging and innovative plan, with eight pathways focusing on different aspects of an interconnected world of information, including end-user instruction, application of technology and promotion of library programs and services.
The ACRL Information Literacy Competency Standards for Higher Education was selected as the conceptual framework for the D eLib Information Literacy Program. It was this planning effort that prompted the librarians to consider multi-media tools, such as videos, to compliment the librarians’ classroom instruction, and to enhance the students’ information related learning experiences and knowledge base.
Within this distributed environment infused with technology D eLib introduced DeLibCasts on select, pre-defined topics from the D eLib Information Literacy Plan to facilitate utilization of our resources and services: keyword search, search limits, my account, among others.
This paper discusses the planning and implementation process of producing videocasts, from identifying a need, acquiring the right software, development of a consistent layout for each video cast, creation of a framework, involving library staff, promotion and delivery. DeLib currently has nine videocasts available and more under production.
An assessment of the D eLibCasts will be part of the comprehensive assessment of D eLib’s Information Literacy Program.
Mandibular Advancement vs Combined Airway and Positional Therapy for Snoring
Authors: Ioerger Patrick , Afshari Azadeh , Hentati Firas , Strober William , Kallogjeri Dorina , Ju Yo-El , Piccirillo Jay F. 
Published: May 2024

ImportanceApproximately 150 million individuals in the US snore in the absence of obstructive sleep apnea (primary snoring), but few studies have examined the efficacy of treatments for snoring or evaluated the effect of snoring in sleeping partners.ObjectiveTo evaluate the efficacy of 2 treatments for primary snoring.Design, Setting, and ParticipantsThis pilot randomized clinical trial that included a convenience sample of people who snore without sleep apnea and their sleeping partner who underwent 4 weeks of snoring treatment was conducted at an academic medical center between October 3, 2022, and July 3, 2023.InterventionsFifty couples were randomized to either use a mandibular advancement device (MAD) or receive combined airway and positional therapy (CAPT; external nasal dilator, nasal saline lavage with mometasone, mouth taping, and lateral positional therapy).Main Outcome and MeasurePercentage of sleeping partners who reported that their partner’s snoring was either very much improved or much improved (responder) on the Clinical Global Impression of Improvement scale.ResultsA total of 42 dyads completed the study; 23 (55%) were randomized to MAD and 19 (45%) to CAPT. Among people who snore, 26 (62%) were female, and the mean (SD) age was 48 (14) years. Of 23 dyads randomized to MAD, 21 people who snore (91%) were rated by the sleeping partner as a responder, while 11 of the 19 dyads (58%) randomized to CAPT were rated by the sleeping partner as responder, resulting in a difference of 33 percentage points (95% CI, 8-58) and a number needed to treat of 3. Of the 10 participants who were withdrawn, 4 were withdrawn due to adverse effects of the treatment that were evenly distributed between the MAD (n = 2) and CAPT (n = 2) groups.Conclusion and RelevanceThe results of this randomized clinical trial showed that the MAD may be more effective than CAPT for treating primary snoring, while both treatment options were found to reduce primary snoring. Physicians should have a patient-centered discussion to determine which treatment is best for individual patients with primary snoring, weighing convenience, adverse effects, and cost as factors.Trial RegistrationClinicalTrials.gov Identifier: NCT05756647
Spontaneous Structuration of Biohydrogels by Membrane‐Free Osmosis
Authors: Guilbert Emilie , de Loubens Clément , Vilotte Alice , Schmitt Christophe , Gunes Deniz , Bodiguel Hugues 
Published: May 2024

AbstractMany bio‐hydrogels are prepared thanks to the addition of divalent ions. These gels usually exhibit partial ionic selectivity, a feature is leveraged to instigate an osmotic flow during the gelation process across a range of bio‐hydrogels. A simple experimental setup consisting a glass capillary filled by the reactant solution is taken as an advantage, brought into contact with a reservoir of calcium chloride. Direct observation allows to characterize the gelation kinetics, the permeability and the selectivity of several gels, including some made of protein aggregates, pectin, and alginate. It is shown that these intrinsic properties, coupled with appropriate gelation kinetics, intricately govern the osmotic flow induced by the chemical potential difference of the calcium chloride ions imposed during gel formation, consistent with the Kedem–Kashalsky equation. The forming gel acts as a semi‐permeable membrane for calcium chloride ions. The consequences of this osmotic flow are of potentially great interest since it triggers an increase of the gel concentration close to its boundary, opening the road to their spontaneous structuration. The formation of this dense shell is well accounted for the combination of a mass balance and a kinetic model.
Polarization‐Induced Mechanically Socketed Ultra‐Stretchable and Breathable Textile‐Based Nanogenerator and Pressure Sensor
Authors: Garg Romy , Majhi Abhisek , P Nagasreenivasarao , Patra Nikhil Ram , Barve Ritesh , Parida Kaushik 
Published: May 2024

AbstractTextile‐based wearable triboelectric nanogenerators (TENGs) have emerged as viable power sources for wearable electronics. However, it is still a daunting challenge to realize a high‐performing textile‐based nanogenerator without compromising its intrinsic textile‐like properties, such as stretchability, breathability, and conformability. The above challenge is addressed by fabricating a record high‐performing wearable, breathable and stretchable nanogenerator based on polarization‐induced ultra‐stretchable EVA/Nylon‐11 micro/nano‐fibers (1250%) as the triboelectric positive layer and polarization‐induced ultra‐stretchable EVA/PVDF/BA2CsAgBiBr7 micro/nano‐fibers (1480%) as the triboelectric negative layer. The excellent stretchability, breathability (1.15 Kgm−2d−1) and high energy‐harvesting performance (650 V, 19.5 µAcm−2) are attributed to the mechanically‐socketed structure of the aligned stretchable EVA microfibers with the polarized nanofibers, thus providing a universal framework to fabricate stretchable piezoelectric fibers. Compositional engineering and polarization‐induced surface charges coupled with triboelectric‐induced surface charges enabled enhanced performance compared to other wearable stretchable textile‐based nanogenerators. Additionally, it is utilized as a stretchable self‐powered pressure sensor with an ultra‐wide pressure sensing range (0.05–500 kPa) and high sensitivity (2.5 VkPa−1) even under deformations. To the best of the knowledge, PI‐STENG stands out amongst various stretchable self‐powered pressure sensors in terms of pressure sensing range and stretchability. The PI‐STENG is demonstrated as a machine learning‐enabled intellisensor for workforce safety monitoring.
Designed 3D Dumpling‐Shaped Femtosecond Laser Structured Light Field for Nanoscale Sensing
Authors: Pan Deng , Fuyang Zhijuan , Wang Hui , Wang Zhiqiang , Kuai Yan , Zhang Chenchu , Lao Zhaoxin , Zhang Jingjing , Ni Jincheng , Xu Bing , Zhen Shenglai , Yu Benli , Wu Dong 
Published: May 2024

AbstractNanoscale optical sensing plays a crucial role in achieving high‐precision non‐contact distance and displacement measurements. As one of the promising alternatives, structured light can greatly simplify optical sensing systems. In this study, a novel optical phenomenon of a structured beam called the “Dumpling‐shaped Structured Light Field” (DSLF) is revealed, which forms during the focusing of cylindrical lens beams. The 3D DSLF comprises two mutually perpendicular primary and secondary foci, offering unique possibilities in micro/nano processing and sensing applications. A thorough investigation of the DSLF is conducted, revealing a correlation between the secondary foci and the phase status at the objective lens's entrance pupil. The propagation of DSLF under tight focus conditions has been verified and discussed through methods of femtosecond laser two‐photon polymerization and light field analysis. Finally, thanks to the unique 3D intensity distribution of 3D DSLF, the applicability of DSLF in high‐precision position and vibration sensing has been demonstrated. By detecting the horizontal and vertical dimensions of the reflected DSLF, position and vibration sensing is achieved with a Z‐direction accuracy of 10 nm (λ/80). This research contributes to understanding structured light, and offers practical applications in various fields, including micro/nano laser processing, optical imaging, sensing, etc.
Photoluminescence Probes Ion Insertion into Amorphous and Crystalline Regions of Organic Mixed Conductors
Authors: Collins Garrett W. , Lone Mohd Sajid , Jackson Seth R. , Keller Jolene N. , Kingsford Rand L. , Noriega Rodrigo , Bischak Connor G. 
Published: May 2024

AbstractOrganic mixed ionic‐electronic conductors (OMIECs) have emerged as promising materials for a wide range of next‐generation technologies, including bioelectronics and neuromorphic computing. The performance of these materials depends on the transport of ions through the polycrystalline polymer matrix as well as how the distribution of ions and polarons in crystalline and amorphous regions impacts electronic transport. However, it is often challenging to distinguish whether ions enter crystalline or amorphous regions. In this work, steady‐state and time‐resolved photoluminescence (PL) spectroelectrochemistry is used to probe initial ion insertion in crystalline and amorphous regions of the OMIEC material poly(3‐[2‐[2‐(2‐methoxyethoxy)ethoxy]ethyl]thiophene ‐2,5‐diyl) (P3MEEET) as a function of applied voltage. It is found that PL spectroelectrochemistry reports on the initial stages of electrochemical doping through the quenching of PL emission. By distinguishing between amorphous and crystalline contributions to the PL spectrum, ion insertion in crystalline and amorphous regions as a function of voltage is tracked. It is found that PL spectroelectrochemistry is much more sensitive to the initial injection of ions than complementary methods, highlighting its potential as a sensitive tool for interrogating ion injection in OMIECs.
Suppressing Shuttle Effect via Cobalt Phthalocyanine Mediated Dissociation of Lithium Polysulfides for Enhanced Li‐S Battery Performance
Authors: Zhang Wei , Zhu Jiawen , Ye Yadong , She Jiaxuan , Kong Xianghua , Jin Song , Peng Zhangquan , Ji Hengxing 
Published: May 2024

AbstractCationic lithium polysulfides (LiPSs) within ether‐based electrolytes are essential intermediates pivotal in instigating the shuttle effect. Suppressing the generation of cationic LiPSs is crucial for enhancing the performance of high‐energy‐density Li‐S batteries in practical applications. Herein, for the first time, it is demonstrated that cobalt phthalocyanine (CoPc) can significantly enhance the dissociation of LiPSs, leading to a decrease in cationic LiPSs species within the electrolyte. Employing NMR and in‐situ Raman spectroscopy, it is observed that CoPc interacts with sulfur anions within LiPSs, modifying the dissociation equilibrium of LiPSs in 1,2‐dimethoxyethane (DME)/1,3‐dioxolane (DOL) electrolyte. This CoPc‐mediated shift toward dissociation equilibrium reduces the concentration of cationic LiPSs, effectively suppressing the electromigration of LiPSs intermediates toward the Li anode during the charging process of Li‐S battery. As a result, the Li‐S battery enabled a high reversible areal capacity of 4.2 mAh cm−2 at a high sulfur loading of 5.0 mg cm−2 and a low electrolyte/sulfur (E/S) ratio of 3 µL mgs−1. This work affords a promising strategy for tackling the fundamental challenges regarding Li‐S batteries.
Bi2S3 Confined by Covalent Organic Frameworks Enables High‐Rate High‐Capacity Potassium Storage
Authors: Li Wentao , Zhang Qingfeng , Pei Quan , Yang Ying , Zhao Jingxin , Xie Shuhong , Huang Jianyu 
Published: May 2024

AbstractPotassium‐ion hybrid capacitors (PIHCs) are highly promising as an energy‐storage system. However, the rate performance and cycling performance of most materials with high capacity cannot simultaneously meet the requirements of PIHCs. In this work, a composite material of Bi2S3 nanoparticles in situ confined within a sulfur‐doped covalent organic framework (COF) and combined with graphene (Bi2S3@SCOF/G) is synthesized. Due to the synergistic effect of the stability of COF to buffer large mechanical stresses and the high electronic conductivity of graphene, the Bi2S3@SCOF/G anode reveals a high reversible capacity (503.8 mAh g−1 at 100 mA g−1 after 100 cycles) and favorable rate performance (223.9 mAh g−1 even at 5000 mA g−1). Furthermore, the PIHCs assembled with activated carbon show excellent energy density and cycling performance, indicating their potential for practical applications.