bluuebunny/crossref_metadata_2025_split huggingface dataset:
PKM Usaha Garam Briket di Kelompok Masmolo Kecamatan Insana Utara Kabupaten Timor Tengah Utara, NTT
Authors: Rita Sila Vinsensia Ulia , Ledheng Ludgardis , Oki Kamilaus Konstanse , Hano’e Emanuel Maria  Yosef 
Published: May 2024

Penggunaan kayu bakar yang berlebihan berdampak buruk bagi lingkungan. Hasil sisa pembakaran berupa arang belum dimanfaatkan secara baik menjadi briket. Briket dapat menjadi pilihan bahan bakar produksi garam. Garam hasil produksi Kelompok Tani Masmolo adalah garam organik yang putih bersih namun belum mendapat sentuhan kemasan yang menarik. Hal ini diakibatkan oleh minimnya pemahaman terhadap pengelolaan paska produksi secara baik. Oleh karena itu, perlu dilakukan upaya pelatihan dan praktek langsung pembuatan briket serta pelatihan desain dan pembuatan kemasan. Tujuan dilakukan kegiatan PKM yakni untuk mengedukasi petani mengenai pemanfaatan arang sebagai bahan baku pembuatan briket serta melatih keterampilan petani mendesain dan membuat kemasan secara baik dan menarik. Ukuran keberhasilan kegiatan dilakukan melalui uji pemahaman melalui sebaran kuisioner bagi setiap anggota tani dengan cara pemberian score pada setiap pertanyaan dari tahapan kegiatan yang diberikan. Berdasarkan hasil kegiatan diketahui secara umum petani memahami semua tahapan kegiatan yang diberikan Tim PKM. Hasil penerapan menunjukkan bahwa keunggulan menggunakan briket yakni produksi garam lebih cepat dimana 500 keping briket yang digunakan mampu memproduksi garam sebanyak 4 kali.
Effect of Psychoeducation on Mental Health among Caregivers of Patients with Chronic Kidney Disease
Authors: Hossain Mohammad Afzal , Akram Uzzaman Muhammad , Muhammad Noor 
Published: May 2024

Chronic Kidney Disease (CKD) is a progressive and debilitating chronic illness that results in irreversible loss of kidney function. Nowadays, caregiving is the central role for patients who are suffering from chronic disease worldwide. Considering this, the present study was conducted to investigate the psychoeducational impact on the mental health of those who care for patients with CKD. A pre-test and post-test method of the quasi-experimental design was employed to conduct the study on a total number of 60 participants (experimental group 30 and control group 30). Participants’ age range was 18 to 59 years and mean and standard deviation were respectively 30.28 and 9.86. An adapted Bangla version of the General Health Questionnaire-28 and Psychoeducation Materials (developed by Hossain et al., 2023) were administered to the participants. Participants were selected purposively from the National Institute of Kidney Diseases and Urology (NIKDU) of Dhaka city. The obtained data were analyzed by using descriptive statistics, mean, standard deviation, t-test, etc. Results indicate that there was a significant difference between the experimental group and the control group in mental health problems (t = 4.274, p < .05). Results also revealed that there were significant differences between the experimental group and the control group in somatic problems (t = 2.412, p < .05), anxiety and insomnia (t = 3.614, p < .05), social dysfunctions (t = 2.916, p < .05) and severe depression (t = 2.588, p < .05) among caregivers of patients with CKD. The findings of the present study indicate that after the psychoeducational training, mental health problems were better than mental health problems before the psychoeducational training. The implications of the findings have been discussed in light of research evidence from earlier research.
Jagannath University Journal of Life and Earth Sciences, 9(2): 179–194, 2023 (December)
OHDSI-compliance: a set of document templates facilitating the implementation and operation of a software stack for real-world evidence generation
Authors: Wirth Felix N. , Abu Attieh Hammam , Prasser Fabian 
Published: May 2024

IntroductionThe open-source software offered by the Observational Health Data Science and Informatics (OHDSI) collective, including the OMOP-CDM, serves as a major backbone for many real-world evidence networks and distributed health data analytics platforms. While container technology has significantly simplified deployments from a technical perspective, regulatory compliance can remain a major hurdle for the setup and operation of such platforms. In this paper, we present OHDSI-Compliance, a comprehensive set of document templates designed to streamline the data protection and information security-related documentation and coordination efforts required to establish OHDSI installations.MethodsTo decide on a set of relevant document templates, we first analyzed the legal requirements and associated guidelines with a focus on the General Data Protection Regulation (GDPR). Moreover, we analyzed the software architecture of a typical OHDSI stack and related its components to the different general types of concepts and documentation identified. Then, we created those documents for a prototypical OHDSI installation, based on the so-called Broadsea package, following relevant guidelines from Germany. Finally, we generalized the documents by introducing placeholders and options at places where individual institution-specific content will be needed.ResultsWe present four documents: (1) a record of processing activities, (2) an information security concept, (3) an authorization concept, as well as (4) an operational concept covering the technical details of maintaining the stack. The documents are publicly available under a permissive license.DiscussionTo the best of our knowledge, there are no other publicly available sets of documents designed to simplify the compliance process for OHDSI deployments. While our documents provide a comprehensive starting point, local specifics need to be added, and, due to the heterogeneity of legal requirements in different countries, further adoptions might be necessary.
Sedentary behavior patterns and bone health among overweight/obesity older women: a cross-sectional study
Authors: He Yixian , Du Litao , Li Qingqian , Ren Xiaoyu , Chen Si , Pan Yang 
Published: May 2024

BackgroundRecent studies have indicated an association between sedentary behavior (SB), particularly patterns of SB, and bone health. However, it remains uncertain how different patterns of SB in overweight/obesity older women impact their bone health. This study aimed to investigate the association between objectively measured SB patterns and bone health in Chinese community-dwelling overweight/obesity older women.MethodsCross-sectional data were obtained from a baseline survey of Physical Activity and Health in Older Women Study. Quantitative ultrasound was used to measure speed of sound (SOS), broadband ultrasound attenuation (BUA), bone quality index (BQI) and T value to evaluate bone health. SB patterns were measured using triaxial accelerometers, including sedentary time in SB bouts of ≥ 10, 30, and 60 min, number of SB bouts ≥ 10, 30, and 60 min. Multiple linear regression was used to examine the associations of different SB patterns with bone health.ResultsAfter adjusting for confounders, sedentary time in SB bouts ≥ 60 min, number of SB bouts ≥ 60 min were significantly associated with bone health, with a lower SOS [β = −2.75, 95% confidence interval (CI): −4.96 to −0.53, P = 0.015], BUA (β = −1.20, 95% CI: −2.14 to −0.26, P = 0.013), BQI (β = −1.56, 95% CI: −2.63 to −0.49, P = 0.004), T value (β = −0.08, 95% CI: −0.14 to −0.03, P = 0.004) per 60 min increase of sedentary time in SB bouts ≥ 60 min, and a lower SOS (β = −3.97, 95% CI: −7.54 to −0.40, P = 0.029), BUA (β = −1.80, 95% CI: −3.44 to −0.16, P = 0.031), BQI (β = −2.28, 95% CI: −4.08 to −0.47, P = 0.014) and T value (β = −0.12, 95% CI: −0.22 to −0.03, P = 0.013) per bout increase of SB bouts ≥ 60 min, respectively.ConclusionLimiting the duration of prolonged sedentary bouts and minimizing the occurrence of number of SB bouts ≥ 60 min could be essential in bone health management, especially for those older people who are overweight/obesity.
Efficacy and safety of Apixaban in the treatment of cerebral venous sinus thrombosis: a multi-center study
Authors: Simaan Naaem , Metanis Issa , Honig Asaf , Hallevi Hen , Filioglo Andrei , Mendel Rom , Barnea Rani , Naftali Jonathan , Auriel Eitan , Aladdin Shorooq , Orion David , Dally Najib , Leker Ronen R. , Molad Jeremy 
Published: May 2024

BackgroundInformation regarding the safety and efficacy of specific direct oral anticoagulants (DOAC) in the treatment of cerebral sinus and venous thrombosis (CSVT) is scarce. Apixaban is one of the most frequently prescribed DOACs. Therefore, we aimed to compare the safety and efficacy of Apixaban with those of vitamin k antagonists (VKA) in patients with CSVT.MethodsProspective CSVT databases from seven academic medical centers were retrospectively analyzed. Patients treated with Apixaban were compared to those treated with VKA. Data on demographics, clinical presentations, risk factors, radiological and outcome parameters were studied.ResultsOverall, 403 patients were included in the analysis. Of them, 48 (12%) were treated with Apixaban, and 355 (88%) were treated with VKA. Rates of coagulopathies were significantly higher in the VKA-treated patients but no other differences between the groups were found in baseline characteristics and underlying etiology. No significant differences were found between groups in efficacy or safety parameters including the rates of recanalization, favorable outcomes, one-year mortality, seizures, intracranial hemorrhage or CSVT recurrences.ConclusionOur data suggests that Apixaban may be safe and effective for patients with CSVT. These results should be tested in prospective randomized clinical studies.
Systematic review of memory assessment in virtual reality: evaluating convergent and divergent validity with traditional neuropsychological measures
Authors: Mancuso Valentina , Sarcinella Eleonora Diletta , Bruni Francesca , Arlati Sara , Di Santo Simona Gabriella , Cavallo Marco , Cipresso Pietro , Pedroli Elisa 
Published: May 2024

IntroductionThe evaluation of memory is a crucial aspect of both cognitive research and clinical applications, as it offers valuable insights into an individual’s cognitive wellbeing and performance. Conventional neuropsychological assessments represent the established method for assessing different aspects of memory. Recent technological advancements, specifically in the field of virtual reality (VR), have introduced novel methods for evaluating memory.ObjectiveThis systematic review aims to examine the current state of memory assessment using VR technologies, assessing the degree of convergence and divergence between VR-based memory assessments and conventional neuropsychological tests.MethodA systematic review of the literature was conducted searching PubMed, PsycINFO, Web of Science databases, leading to the incorporation of 24 studies. Studies were grouped according to the examined memory domain (episodic, prospective, spatial domain). Convergence and divergence validity were examined for each, and information on software and hardware features was collected.ResultsThis review demonstrates a notable alignment between VR-based memory assessments and conventional neuropsychological tests. Moreover, VR tasks have shown to exhibit associations with executive functions and overall cognitive performance. The inclusion of various ecological contexts, such as residential environments, commercial establishments, and simulated scenarios, serves to augment the ecological validity of memory evaluations conducted in VR.DiscussionThe findings indicate that VR assessments demonstrate a functional perspective by effectively capturing the dynamic relationship between memory, executive functions, and overall cognitive performance. Nevertheless, it is imperative to acknowledge and tackle certain constraints that may hinder the widespread adoption and utilization of VR tasks. These limitations encompass factors such as restricted accessibility to VR tasks and the presence of heterogeneity in VR hardware and software. The dynamic and ever-changing nature of VR technology presents a range of potential avenues for future investigation and utilization in the domain of memory evaluation.
Clinical characteristics, treatment patterns, and outcomes in adult patients with germline BRCA1/2-mutated, HER2-negative advanced breast cancer: a retrospective medical record review in the United States
Authors: Obeid Elias , Parikh Rohan C. , Esterberg Elizabeth , Arondekar Bhakti , Hitchens Abigail , Arruda Lillian Shahied , Niyazov Alexander , Whitaker Kristen 
Published: May 2024

AimTo examine clinical characteristics, real-world treatment patterns, and health outcomes among patients with germline BRCA1/2-mutated, human epidermal growth factor receptor 2 (HER2)–negative advanced breast cancer (ABC).MethodsA retrospective analysis was conducted using medical records from patients with HER2-negative ABC with BRCA1/2 mutation who received cytotoxic chemotherapy. Data were stratified into groups with triple-negative breast cancer (TNBC) or hormone receptor–positive (HR+)/HER2-negative diagnoses. Time-to-event outcomes (i.e., real-world progression-free survival [rwPFS] and overall survival [OS]) were calculated to summarize health outcomes.ResultsWhen diagnosed with ABC, most patients were younger than 60 years (mean age = 57.3 years), were white (76.4%), and had a family history of BRCA-related cancer (71.5%). A total of 305 patient records were examined; 194 patients (63.6%) had advanced TNBC, and 111 patients (36.4%) had HR+/HER2-negative ABC. Chemotherapy was primarily used as first-line treatment for both subgroups, but the TNBC subgroup received poly (ADP-ribose) polymerase (PARP) inhibitors at triple the rate as a second-line treatment and double the rate as a third-line treatment compared with the HR+/HER2-negative subgroup. Two-year OS rates were similar between the TNBC (73.9%) and the HR+/HER2-negative subgroups (77.0%), and anemia, nausea, and neutropenia were the most commonly reported toxicities across all treatments.ConclusionClinicians should consider the use of targeted agents such as PARP inhibitors in earlier lines of therapy for ABC given the growing evidence that PARP inhibitors may improve PFS compared with chemotherapy while potentially offering a more manageable toxicity profile and improved quality of life.
Impact of cavity shave margins in patients with ductal carcinoma in situ undergoing conserving breast surgery
Authors: Vanni Gianluca , Pellicciaro Marco , Materazzo Marco , Marsella Valentina , Usai Valeria , Noce Annalisa , Buonomo Oreste Claudio 
Published: May 2024

AimThe main challenge during breast-conserving surgery (BCS) is to obtain clear margins, especially in patients with ductal carcinoma in situ (DCIS) due to the absence of well-defined nodules. Many surgical approaches have been used in an attempt to reduce the positive margin rate. The aim of this retrospective study is to compare the cavity shave margin technique with standard surgery and the intraoperative evaluation of surgical margins.MethodsThis is a single-center retrospective study analyzing margin status, need for re-excision, and surgical time in a cohort of 227 patients who underwent surgery from September 2016 to September 2022.ResultsIn patients subjected to cavity shaving, we reported a significant reduction in positive margins of 17.1% versus 28.7% (p-value = 0.042). Also, a difference in terms of surgical re-excision was reported as p-value = 0.039 (12.4% versus 23.8%, respectively, for the cavity shave and control group). In the multivariate analysis, intraoperative evaluation of the margins was a risk factor for margins re-excision (Wald = 4.315, p = 0.038, OR: 2.331 [95% CI: 1.049–5.180]). Surgical time was lower in patients subjected to cavity shaves (p = 0.024), and the relative mean time was 68.4 min ± 37.1 min in the cavity shave group versus 93.9 min ± 40.6 min in the control group.ConclusionThe cavity shave margin technique in conserving breast surgery results in a reduction in positive margin rate, surgical re-excision, and operative time.
Similarity judgements: the comparison of normative predictions and subjective evaluations – A study of the ratio model of similarity in social context
Authors: Jabłońska Magdalena Zyta , Falkowski Andrzej , Mackiewicz Robert 
Published: May 2024

IntroductionThis study examines the consistency between subjective similarity evaluations and the theoretical predictions derived from Tversky’s ratio model of similarity, alongside the impact of additional positive and negative features on perceived similarity to ideal and bad politicians.MethodsUsing a sample of 120 participants, we assessed the similarity of eight candidate profiles to an ideal and bad politician, varying in positive and negative features. Participants’ subjective evaluations were compared with theoretical predictions derived from Tversky’s ratio model. The analysis focused on how candidate and referent valence influenced observed versus theoretical similarity.ResultsSubjective similarity judgments deviated systematically from theoretical predictions, especially for positively featured candidates, indicating a negativity effect. Additional positive features decreased the perceived similarity of favorable candidates to an ideal politician, while additional negative features did not significantly affect similarity judgments of unfavorable candidates.DiscussionOur findings underscore a significant disparity between subjective and objective similarity judgments, notably for favorable candidates. While the ratio model performs well for unfavorable candidates, its applicability diminishes for favorable ones, emphasizing the role of feature valence in decision-making. Further research on feature valence is crucial for a comprehensive understanding across contexts.
VR-assisted aggression treatment in forensic psychiatry: a qualitative study in patients with severe mental disorders
Authors: González Moraga Fernando Renee , Enebrink Pia , Perrin Sean , Sygel Kristina , Veling Wim , Wallinius Märta 
Published: May 2024

IntroductionImprovements in virtual reality (VR) have made it possible to create realistic, virtual settings for behavioral assessment and skills training that cannot otherwise be accessed in a safe way in forensic psychiatric settings. VR interventions are under development but little is known how forensic psychiatric patients with severe mental disorders experience VR-assisted assessments or treatments.MethodsThe present study aimed to help fill this knowledge gap via qualitative interviews with seven patients with severe mental disorders at a high-security forensic psychiatric clinic who had completed the newly revised Virtual Reality Aggression Prevention Training (VRAPT). All participants were interviewed 12 weeks after the VRAPT intervention, and interview data analyzed with manifest inductive content analysis. ResultsSix manifest content categories were identified: 1. Therapeutic process, 2. VRAPT method, 3. VR technology, 4. Previous treatment experiences, 5. Challenges to treatment of aggression, and 6. Unexpected experiences. The participants had diverse experiences related to both the VRAPT intervention and forensic psychiatric care. Participants described a mixture of positive experiences in relation to VR-assisted role-plays, and less positive in relation to motivation for aggression-focused treatment and technological limitations. DiscussionThe present findings suggest further studies are needed on how to best implement VR-assisted treatments for aggression in forensic settings, and potentially further modification of treatment content in interventions like VRAPT.
Susceptibility to e-cigarette adoption among tobacco-naïve youths: a cross-sectional study in Shenzhen, China
Authors: Yan Ruilin , Liu Yanhong , Huang Li , Li Yanrou , Huang Yun , Tong Jing , Deng Yongzheng , Yuan Qing 
Published: May 2024

BackgroundThe rise in e-cigarette use among youth is a significant global public health issue. It is important to identify those at increased risk and implement effective strategies to reduce e-cigarette popularity among the youth.ObjectiveThis study aims to identify predictors of e-cigarette uptake in youths with no prior tobacco use, considering individual, familial and the broader societal environmental factors.MethodsFor this investigation, a group of 2,487 tobacco-free youths was selected from 15 high schools in Shenzhen, China. Susceptibility to e-cigarettes was determined by assessing the possibility of future use and the openness to trying e-cigarettes if presented by friends. Both chi-square tests and logistic regression were applied to identify factors linked to susceptibility to e-cigarette use.ResultsAmong the respondents, 5.5% (n = 136) were found to be susceptible to e-cigarette use. The analysis revealed factors tied to this risk: perceptions of e-cigarettes, the impact of vaping peers, paternal parenting styles, the extent of social support, exposure to messages both for and against e-cigarettes use, and secondhand smoke (SHS) exposure. Youths who downplayed the addictive nature of e-cigarettes (aOR = 2.01; 95% CI: 1.14–3.55; p = 0.016), those with friends who engaged in vaping (aOR = 3.43–7.64; 95%CI: 2.36–20.42; p &lt; 0.001), those experiencing over-protective or rejective maternal parenting (aOR = 1.68–3.01; 95%CI: 1.11–5.77; p = 0.001–0.014) or rejective paternal parenting (aOR = 3.63; 95%CI: 1.99–6.59; p &lt; 0.001), those aware of e-cigarette advertisements (aOR = 1.82; 95%CI: 1.28–2.60; p = 0.001), and those exposed to SHS at home (aOR = 1.68; 95%CI: 1.17–2.41; p = 0.005) or at public places (aOR = 1.72–1.79; 95%CI: 1.21–2.57; p = 0.002–0.003) were more prone to e-cigarettes. In contrast, youths who believed using e-cigarettes reduces one’s attractiveness (aOR = 0.34; 95%CI: 0.16–0.72; p = 0.005) or perceived that vaping made social interactions less enjoyable (aOR = 0.26; 95%CI: 0.12–0.58; p = 0.001), those who benefited from high social support (aOR = 0.30–0.60; 95%CI: 0.17–0.97; p &lt; 0.001), and those who noticed message about e-cigarettes’ adverse consequence (aOR = 0.54; 95%CI: 0.38–0.77; p = 0.001) were less likely to be inclined toward e-cigarette use.ConclusionThe propensity of the youth to e-cigarette usage is shaped by a multiple element. An all-encompassing strategy that addresses the individual, familial, and the broader societal aspects is imperative for the effective prevention of e-cigarette initiation among youth.