bluuebunny/crossref_metadata_2025_split huggingface dataset:
ChemInform Abstract: Microwave‐Promoted Selective Mono‐N‐alkylation of Anilines with Tertiary Amines by Heterogeneous Catalysis.
Authors: Lubinu M. Caterina , De Luca Lidia , Giacomelli Giampaolo , Porcheddu Andrea 
Published: April 2011

AbstractThe present new method for the palladium‐catalyzed N‐alkylation of anilines with tertiary amines occurs under heterogeneous transfer‐hydrogenation conditions.
ChemInform Abstract: Dienyl Homoallyl Alcohols via Palladium Catalyzed Ene‐Type Reaction of Aldehydes with 1,3‐Dienes.
Authors: Fukushima Masahiro , Takushima Daiki , Kimura Masanari 
Published: April 2011

AbstractThe reaction occurs selectively at the C—C double bond bearing higher electron density.
ChemInform Abstract: Self‐Assembled Proline‐Amino Thioureas as Efficient Organocatalysts for the Asymmetric Michael Addition of Aldehydes to Nitroolefins.
Authors: Wang Wan‐Hui , Abe Takeshi , Wang Xiang‐Bo , Kodama Koichi , Hirose Takuji , Zhang Guang‐You 
Published: April 2011

AbstractBoth the reaction rate and the enantioselectivity are significantly improved upon in less polar solvents.
ChemInform Abstract: A Convenient Synthesis of (E)‐α,β‐Unsaturated Esters with Total Stereoselectivity Promoted by Catalytic Samarium Diiodide.
Authors: Concellon Jose M. , Rodriguez‐Solla Humberto , Concellon Carmen , Diaz‐Pardo Ainhoa , Llavona Ricardo 
Published: April 2011

AbstractA new β‐elimination reaction allows the stereoselective synthesis of (E)‐α,β‐unsaturated esters by reaction of α‐halo‐β‐hydroxy esters with magnesium in the presence of samarium iodide as catalyst.
ChemInform Abstract: A General Palladium‐Catalyzed Carbonylative Sonogashira Coupling of Aryl Triflates.
Authors: Wu Xiao‐Feng , Sundararaju Basker , Neumann Helfried , Dixneuf Pierre H. , Beller Matthias 
Published: April 2011

AbstractThe present new method for carbonylative Sonogashira reactions of aryl triflates with alkynes results in the formation of alkynones which are useful building blocks for the synthesis of biologically active compounds.
ChemInform Abstract: N‐Heterocyclic Carbene‐Catalyzed Tandem Aza‐Benzoin/Michael Reactions: On Site Reversal of the Reactivity of N‐Boc Imines.
Authors: Wu Ke‐Jia , Li Gong‐Qiang , Li Yi , Dai Li‐Xin , You Shu‐Li 
Published: April 2011

AbstractA highly stereoselective tandem N‐heterocyclic carbene‐catalyzed aza‐benzoin/Michael reaction as a method to efficiently afford dihydroindenones (III) and pyrrolidinone‐containing tricycles (IV) is described.
ChemInform Abstract: Cross Metathesis of N‐Allylamines and α,β‐Unsaturated Carbonyl Compounds: A One‐Pot Synthesis of Substituted Pyrroles.
Authors: Shafi Syed , Kedziorek Mariusz , Grela Karol 
Published: April 2011

AbstractA novel protocol allows the synthesis of a variety of pyrroles from N‐functionalized allyl amines, aldehydes or ketones.
ChemInform Abstract: CCC—N‐Heterocyclic Carbene Pincer Complexes: Synthesis, Characterization and Hydroamination Activity of a Hafnium Complex.
Authors: Cho Joon , Hollis T. Keith , Valente Edward J. , Trate Jaclyn M. 
Published: April 2011

AbstractThe hafnium compound HFC effectively promotes the intramolecular hydroamination of unactivated alkenes yielding pyrrolidine and piperidine derivatives.
ChemInform Abstract: One‐Pot Synthesis of N‐Substituted Pyrroles Catalyzed by Polystyrene‐Supported Aluminum Chloride as a Reusable Heterogeneous Lewis Acid Catalyst.
Authors: Rahmatpour Ali , Aalaie Jamal 
Published: April 2011

AbstractPolystyrene‐supported aluminum chloride is used as catalyst in Paal‐Knorr pyrrole synthesis for the first time.
ChemInform Abstract: An Efficient Synthesis of Methyl Esters of Heterocyclic α,β‐Didehydro‐α‐amino Acid Derivatives.
Authors: Pozgan Franc , Lukman Klavdija , Kocevar Marijan 
Published: April 2011

AbstractA simple and general method for the selective esterification of the title amino acids without destruction of the C=C bond is presented.
ChemInform Abstract: New Access to 5‐Substituted 1,3‐Benzothiazol‐2(3H)‐ones and Their N‐Methyl Analogues by a Palladium Coupling Reaction.
Authors: Pirat Celine , Ultre Vincent , Lebegue Nicolas , Berthelot Pascal , Yous Said , Carato Pascal 
Published: April 2011

AbstractA new route for the synthesis of the title compounds via Stille and Suzuki reactions is presented.
ChemInform Abstract: A Novel Approach to 1‐Monosubstituted 1,2,3‐Triazoles by a Click Cycloaddition/Decarboxylation Process.
Authors: Xu Mei , Kuang Chunxiang , Wang Zhuo , Yang Qing , Jiang Yubo 
Published: April 2011

AbstractThe novel protocol works under mild conditions and renders possible the preparation of a broad spectrum of triazoles from aryl and vinyl azides including various functionalities.
ChemInform Abstract: Synthesis of Novel 1‐Hydroxyquinolones with High anti‐Toxoplasma Activity.
Authors: Tietze Lutz F. , Ma Ling 
Published: April 2011

AbstractFour novel hydroxyquinolones containing different side chains are prepared via Conrad—Limpach cyclizations, carried out in a two‐step fashion [(V)→(VII), (XII)→(XIII)].
ChemInform Abstract: Reaction of 3‐Hydroxyquinoline‐2,4‐diones with Isocyanates and Thermally Induced Transformation of the Reaction Products.
Authors: Mrkvicha Vladimir , Lycka Antonin , Vicha Robert , Klasek Antonin 
Published: April 2011

AbstractReaction of diones (I) and (V) with isocyanates gives the hitherto unknown dioxoquinolinyl carbamates (III) and/or oxazolo[5,4‐c]quinolinediones (IV).
ChemInform Abstract: Synthesis of Quinolino[2′,3′:7,6]cyclohept[b]indoles and Their Antimicrobial Activities.
Authors: Yamuna Ezhumalai , Prasad Karnam Jayarampillai Rajendra 
Published: April 2011

AbstractA general and simple one‐pot method for the synthesis of the title compounds (III) is presented along with a less efficient two‐step route.
ChemInform Abstract: Dehydrogenation of 5,6‐Dihydropyrido[2,3‐d]pyrimidin‐7(8H)‐ones: A Convenient Last Step for a Synthesis of Pyrido[2,3‐d]pyrimidin‐7(8H)‐ones.
Authors: Perez‐Pi Irene , Berzosa Xavier , Galve Inaki , Teixido Jordi , Borrell Jose I. 
Published: April 2011

AbstractTwo new protocols for the dehydrogenation of 5,6‐dihydropyrido[2,3‐d]pyrimidin‐7(8H)‐ones (I) are presented.
ChemInform Abstract: Hydrosilylation of Alkynes Catalyzed by Platinum on Titania
Authors: Alonso Francisco , Buitrago Robison , Moglie Yanina , Ruiz‐Martinez Javier , Sepulveda‐Escribano Antonio , Yus Miguel 
Published: April 2011

AbstractIt allows efficient, regio‐ and stereoselective formation of a wide range of vinyl silanes.
ChemInform Abstract: Enantioselective Synthesis of the C(2)—C(11) Cyclopropylfuran Segment of Pinnatin A.
Authors: Tsubuki Masayoshi , Abekura Terunobu , Takahashi Kazunori , Honda Toshio 
Published: April 2011

AbstractAn enantioselective synthesis of cyclopropylfuran derivative (V), the C‐2—C‐11 segment of pinnatin A, is accomplished using the silver(I) oxide promoted Suzuki cross‐coupling of chiral cyclopropylboronic acid (II) with bromofuran (III) as key step.
ChemInform Abstract: A New Dimeric Iridal Triterpenoid from Belamcanda chinensis with Significant Molluscicide Activity
Authors: Song Zhi‐Jun , Xu Xue‐Min , Deng Wen‐Long , Peng Shu‐Lin , Ding Li‐Sheng , Xu Han‐Hong 
Published: April 2011

Abstract[i.e.
ChemInform Abstract: Total Synthesis of Bioactive Indolo[3,2‐j]phenanthridine Alkaloid, Calothrixin B.
Authors: Tohyama Shigeo , Choshi Tominari , Matsumoto Kohji , Yamabuki Akira , Hieda Yuhzo , Nobuhiro Junko , Hibino Satoshi 
Published: April 2011

AbstractThe synthesis of calothrixin B (V) is investigated by using three routes.
ChemInform Abstract: A Concise Total Synthesis of (.+‐.)‐Centrolobine.
Authors: Fuwa Haruhiko , Noto Kenkichi , Sasaki Makoto 
Published: April 2011

Abstract(.+‐.)‐Centrolobine (V) is obtained in four linear steps starting from commercially available p‐benzyloxybenzaldehyde via a domino olefin cross‐metathesis/intramolecular oxa‐conjugate cyclization key step.
ChemInform Abstract: Development of a New Class of Benzoylpyrrole‐Based PPARα/γ Activators.
Authors: Ushiroda Kantaro , Maruta Katsunori , Kitoh Makoto , Iwai Kiyotaka , Nagamine Jun , Tsuchida Atsushi , Taiji Mutsuo , Nagata Ryu 
Published: April 2011

AbstractA series of benzoylpyrrole‐based carboxylic acids are designed and synthesized as peroxisome proliferator‐activated receptor (PPAR) activators.
ChemInform Abstract: Bifunctional 2,5‐Diketopiperazines as Rigid Three‐Dimensional Scaffolds in Receptors and Peptidomimetics
Authors: Ressurreicao Ana Sofia M. , Delatouche Regis , Gennari Cesare , Piarulli Umberto 
Published: April 2011

AbstractReview: 76 refs.
Enzymatic Hydrolysis of Lignocellulose in a Fixed Bed Reactor
Authors: Kirsch Christian , Wörmeyer Kai , Zetzl Carsten , Smirnova Irina 
Published: April 2011

AbstractBei der Nutzung lignocellulosehaltiger Biomasse führen hohe Feststoffbeladungen im Rührkessel noch zu Problemen bei der enzymatischen Hydrolyse. Die Integration von thermischer Vorbehandlung und enzymatischer Hydrolyse der Biomasse in einem Festbettreaktor wird daher in dieser Arbeit untersucht. Es wird gezeigt, dass der Einfluss von Pumpen auf die Enzymaktivität für eine spätere Anwendung vernachlässigbar ist, starke Druckabfälle sich jedoch negativ auf die Enzyme auswirken. Eine mechanische Vorbehandlung vor der thermischen Hydrolyse bietet deutliche Vorteile bei der Enzymreaktion (> 95 % Umsatz nach 48 h für pelletiertes Stroh). Desweiteren wird die enzymatische Hydrolyse im Festbett bei verschiedenen Feststoff‐Konzentrationen (7 – 20 %) gezeigt.
Automatic quantification of microtubule dynamics enables RNAi‐screening of new mitotic spindle regulators
Authors: Sironi Lucia , Solon Jérôme , Conrad Christian , Mayer Thomas U. , Brunner Damian , Ellenberg Jan 
Published: April 2011

AbstractThe genetic integrity of every organism depends on the faithful partitioning of its genome between two daughter cells in mitosis. In all eukaryotes, chromosome segregation requires the assembly of the mitotic spindle, a bipolar array of dynamic microtubules. Perturbations in microtubule dynamics affect spindle assembly and maintenance and ultimately result in aberrant cell divisions. To identify new regulators of microtubule dynamics within the hundreds of mitotic hits, reported in RNAi screens performed in C. elegans, Drosophila and mammalian tissue culture cells [Sonnichsen et al., 2005; Goshima et al., 2007; Neumann et al., 2010], we established a fast and quantitative assay to measure microtubule dynamics in living cells. Here we present a fully automated workflow from RNAi transfection, via image acquisition and data processing, to the quantitative characterization of microtubule behaviour. Candidate genes are knocked down by solid‐phase reverse transfection with siRNA oligos in HeLa cells stably expressing EB3‐EGFP, a microtubule plus end marker. Mitotic cells are selected using an automatic classifier [Conrad et al., 2011] and imaged on a spinning disk confocal microscope at high temporal and spatial resolution. The time‐lapse movies are analysed using a multiple particle tracking software, developed in‐house, that automatically detects microtubule plus ends, tracks microtubule growth events over consecutive frames and calculates growth speeds, lengths and lifetimes of the tracked microtubules. The entire assay provides a powerful tool to analyse the effect of essential mitotic genes on microtubule dynamics in living cells and to dissect their contribution in spindle assembly and maintenance.
Circulating estradiol, but not testosterone, is a significant predictor of high‐grade prostate cancer in patients undergoing radical prostatectomy
Authors: Salonia Andrea , Gallina Andrea , Briganti Alberto , Suardi Nazareno , Capitanio Umberto , Abdollah Firas , Bertini Roberto , Freschi Massimo , Rigatti Patrizio , Montorsi Francesco 
Published: April 2011

AbstractBACKGROUND:The objective of this study was to assess the association between preoperative circulating levels of 17β‐estradiol (E2) and high‐grade prostate cancer (HGPCa) (Gleason grade ≥4 + 3) at the time patients underwent radical retropubic prostatectomy (RRP).METHODS:Serum total testosterone (tT), sex hormone‐binding globulin (SHBG), and E2 levels were measured the day before surgery (8‐10 AM) in a cohort of 655 consecutive Caucasian‐ European patients who underwent RRP at a single institution. Logistic regression models were used to test the association between predictors (including age, body mass index, prostate‐specific antigen [PSA], clinical tumor classification, biopsy Gleason sum, tT, SHBG, and E2) and HGPCa. Serum E2 was included in the model as both a continuous variable and a categorized variable (according to the most informative cutoff: 50 pg/mL).RESULTS:Pathologic HGPCa was identified in 156 patients (23.8%). Patients with HGPCa had significantly higher PSA, clinical tumor classification, and biopsy Gleason sum than those without HGPCa (all P < .001). No other significant differences were observed between groups. At univariate analysis, continuously coded E2 was not associated significantly with HGPCa (odds ratio [OR], 1.009; P = .25), whereas patients with E2 levels ≥50 pg/mL had a 3.24‐fold increased risk of HGPCa (P < .001). At multivariate analysis, E2 was associated significantly with HGPCa both as a continuous predictor (OR, 1.02; P = .04) and as a categorical predictor (OR, 3.94; P < .001) after accounting for other variables. Conversely, tT and SHBG levels were not associated significantly with HGPCa.CONCLUSIONS:E2 was associated significantly with pathologic HGPCa, whereas SHBG and tT failed to demonstrate any association with HGPCa in patients who underwent RRP. Cancer 2011;. © 2011 American Cancer Society.
Performance analysis of multi‐level parallelism: inter‐node, intra‐node and hardware accelerators
Authors: Hackenberg Daniel , Juckeland Guido , Brunst Holger 
Published: April 2011

SUMMARYThe advent of multi‐core processors has made parallel computing techniques mandatory on mainstream systems. With the recent rise in hardware accelerators, hybrid parallelism adds yet another dimension of complexity to the process of software development. The inner workings of a parallel program are usually difficult to understand and verify. This paper presents a tool for graphical program flow analysis of hardware accelerated parallel programs. It monitors the hybrid program execution to record and visualize many performance relevant events along the way. Representative real‐world applications written for both IBM's Cell processor and NVIDIA's CUDA API are studied exemplarily. With our combined monitoring and visualization approach for hardware accelerated multi‐core and multi‐node systems we take the next step in tool evolution towards a highly improved level of detail, precision, and completeness. The contents of this paper is of interest to developers of hardware accelerated applications as well as performance tool architects. Copyright © 2011 John Wiley & Sons, Ltd.
Rapid and cheap prototyping of a microfluidic cell sorter
Authors: Islam M. Z. , McMullin J. N. , Tsui Y. Y. 
Published: April 2011

AbstractDevelopment of a microfluidic device is generally based on fabrication‐design‐fabrication loop, as, unlike the microelectronics design, there is no rigorous simulation‐based verification of the chip before fabrication. This usually results in extremely long, and hence expensive, product development cycle if micro/nano fabrication facilities are used from the beginning of the cycle. Here, we illustrate a novel approach of device prototyping that is fast, cheap, reliable, and most importantly, this technique can be adopted even if no state‐of‐the‐art microfabrication facility is available. A water‐jet machine is used to cut the desired microfluidic channels into a thin steel plate which is then used as a template to cut the channels into a thin sheet of a transparent and cheap polymer material named Surlyn® by using a Hot Knife™. The feature‐inscribed Surlyn sheet is bonded in between two microscope glass slides by utilizing the techniques which has been being used in curing polymer film between dual layer automotive glasses for years. Optical fibers are inserted from the sides of chip and are bonded by UV epoxy. To study the applicability of this prototyping approach, we made a basic microfluidic sorter and tested its functionalities. Sample containing microparticles is injected into the chip. Light from a 532‐nm diode laser is coupled into the optical fiber that delivers light to the interrogation region in the channel. The emitted light from the particle is collected by a photodiode (PD) placed over the detection window. The device sorts the particles into the sorted or waste outlets depending on the level of the PD signal. We used fluorescent latex beads to test the detection and sorting functionalities of the device. We found that the system could detect all the beads that passed through its geometric observation region and could sort almost all the beads it detected. © 2011 International Society for Advancement of Cytometry
The emergence of eating pathology after bariatric surgery: A rare outcome with important clinical implications
Authors: Marino Joanna M. , Ertelt Troy W. , Lancaster Kathy , Steffen Kristine , Peterson Lisa , de Zwaan Martina , Mitchell James E. 
Published: April 2011

AbstractObjective:The present review examines the extant literature regarding the post‐operative development of eating disorders (e.g., EDNOS) in bariatric surgery patients.Method:Internet, PsycINFO, Pubmed, and reference lists were examined to aggregate and compare literature from January 1985 to May 2010.Results:Several case studies and case series have investigated the emergence of eating disorders after bariatric surgery. Clinical considerations are outlined.Discussion:The development of classical eating disorders after bariatric surgery appears to be a rare occurrence; however, eating problems are far more common. Unfortunately no typology exists to classify such eating problems. Future research should examine the incidence, risk factors, symptomatology, course, and outcome of such eating disorders and eating problems. It is highly likely that such problems are underreported. © 2011 by Wiley Periodicals, Inc. (Int J Eat Disord 2012)
Challenges in conducting a multi‐site randomized clinical trial comparing treatments for adolescent anorexia nervosa
Authors: Lock James , Brandt Harry , Woodside Blake , Agras Stewart , Halmi W. Katherine , Johnson Craig , Kaye Walter , Wilfley Denise 
Published: April 2011

AbstractObjective:To describe obstacles in the implementation of a controlled treatment trial of adolescent anorexia nervosa (AN).Method:The original aim was to enter 240 participants with AN to one of four cells: Behavioral family therapy (BFT) plus fluoxetine; BFT plus placebo; systems family therapy (SFT) plus fluoxetine; SFT plus placebo.Results:Recruitment was delayed pending a satisfactory resolution concerning participant safety. After 6 months of recruitment it became clear that the medication was associated with poor recruitment leading to a study redesign resulting in a comparison of two types of family therapy with a projected sample size of 160. One site was unable to recruit and was replaced.Discussion:Problems with the delineation of safety procedures, recruitment, re‐design of the study, and replacement of a site, were the main elements resulting in a 1‐year delay. Suggestions are made for overcoming such problems in future AN trials. © 2011 by Wiley Periodicals, Inc. (Int J Eat Disord 2012)
Feeding disorders of infancy: A longitudinal study to middle childhood
Authors: Ammaniti Massimo , Lucarelli Loredana , Cimino Silvia , D'Olimpio Francesca , Chatoor Irene 
Published: April 2011

AbstractObjective:To evaluate over time feeding behavior and emotional–behavioral functioning in a sample of children diagnosed with Infantile Anorexia (IA) and a group of typically developing children; and to investigate the relationship between maternal psychological functioning and the children's feeding patterns and emotional‐behavioral functioning.Method:Seventy‐two children diagnosed with IA and 70 children in the control group were prospectively evaluated through several measures at two, five, and eight years of age.Results:Our findings revealed partial improvement in the nutritional status of the children with IA. However, they continued to show ongoing eating problems and, in addition, anxiety/depression and withdrawal, as well as rule‐breaking behaviors and social problems. There were significant correlations between the children's eating problems and their emotional difficulties and their mothers' increased emotional distress and disturbed eating attitudes.Discussion:Our longitudinal study points out that the natural course of untreated IA is characterized by the persistence of difficulties in eating behavior and emotional–behavioral adjustment in both, the children and their mothers. © 2011 by Wiley Periodicals, Inc. (Int J Eat Disord 2012)
Micropolygyria in an infant born to a patient with severe anorexia nervosa: A case report
Authors: Takei Yuichi , Suda Masashi , Aoyama Yoshiyuki , Narita Kosuke , Kameyama Masaki , Uehara Toru , Fukuda Masato , Mikuni Masahiko 
Published: April 2011

AbstractWe report the case of an anorexia nervosa (AN) patient with extremely low body weight who became pregnant following ovulation induction and subsequently delivered an infant with micropolygyria. To the best of our knowledge, no previous report has described live birth for a patient with such low body weight. The patient underwent hMG‐hCG therapy for ovulation induction. Despite becoming pregnant, weight loss continued with extreme anemia occurring during the pregnancy. However, blood transfusion therapy was used for successful treatment. Despite the therapeutic and protective measures instituted, the child was born with micropolygyria. Pregnancy in an AN patient with extremely low body weight needs therapeutic intervention during early pregnancy with aggressive precautionary measures, particularly against anemia. On the basis of our experience, we consider that ovulation induction therapy should not be administered without sufficient caution for an AN patient with low body weight. © 2011 by Wiley Periodicals, Inc. Int J Eat Disord 2012
Characteristics of persons with an eating disorder and type 1 diabetes and psychological comparisons with persons with an eating disorder and no diabetes
Authors: Powers Margaret A. , Richter Sara , Ackard Diann , Gerken Stephanie , Meier Marcia , Criego Amy 
Published: April 2011

AbstractObjectives:Describe characteristics of patients who have both an eating disorder and type 1 diabetes and compare their responses on psychological tests with those with an eating disorder and no diabetes at time of initial assessment to an eating disorder facility.Method:A chart audit conducted on all 48 patients with ED‐DMT1 who were seen collaboratively by the diabetes and eating disorder treatment teams between 2005 and 2008 at Park Nicollet Health Services and 96 (1:2) matched eating disordered controls.Results:Diabetes was diagnosed an average of 10.2 years (SD = 9.4) before the diagnosis of an eating disorder; HbA1c at initial assessment was 11% (±3.2%). Those without diabetes reported greater depression (p = .048) and greater state and trait anxiety (p = .015 and p = .039, respectively) at initial assessment.Discussion:Persons with both an eating disorder and type 1 diabetes were less psychologically compromised than their matched cohorts with an eating disorder only. These findings may not remain constant during the course of treatment. © 2011 by Wiley Periodicals, Inc. (Int J Eat Disord 2012)