bluuebunny/crossref_metadata_2025_split huggingface dataset:
Risk, Characteristics, and Prognosis of Breast Cancer after Hodgkin's Lymphoma
Authors: Veit-Rubin Nikolaus , Rapiti Elisabetta , Usel Massimo , Benhamou Simone , Vinh-Hung Vincent , Vlastos Georges , Bouchardy Christine 
Published: May 2012

Abstract

Learning Objectives
After completing this course, the reader will be able to: Explain the differences in risk and aggression of breast cancer for Hodgkin's lymphoma survivors.Describe the difference in breast tumor sites for Hodgkin's lymphoma survivors.Use adapted guidelines for surveillance and treatment of these high-risk patients.
CME This article is available for continuing medical education credit at CME.TheOncologist.com

Purpose.
To assess breast cancer (BC) risk after Hodgkin's lymphoma (HL) and compare characteristics, risk of second BC, and prognosis of patients with these BCs with patients with first primary BC.

Patients and Methods.
We considered all 9,620 women with HL recorded in the Surveillance, Epidemiology and End Results dataset in 1973–2007. We calculated age-period standardized incidence ratios of BC. We compared patient, tumor, and treatment characteristics, risk of second BC, and prognosis between patients with BC after HL (n = 316) and patients with other BCs occurring during the same period (n = 450,413) using logistic regression and Cox models adjusted for confounders.

Results.
HL patients had a 2.4-fold higher risk for developing BC (95% confidence interval [CI], 2.2–2.7) than the general population. Age at HL diagnosis and radiation therapy influenced this risk. Compared with first primary BCs, BCs after HL were diagnosed at a younger age, at an earlier stage, were less frequently hormone receptor positive, were located more frequently in external quadrants, and were less frequently treated using radiotherapy. These patients had a higher risk (adjusted hazard ratio [HR], 2.85; 95% CI, 1.79–4.53) for developing a second BC and had a higher BC mortality risk (adjusted HR, 1.36; 95% CI, 1.05–1.76). The higher mortality risk was only partly explained by the higher occurrence rate of a second BC.

Conclusion.
HL survivors have a higher risk for developing BC, their BCs are more aggressive, they have a higher risk for a second BC occurrence, and they have a poorer prognosis. Guidelines of care should be adapted to decrease the impact of BC in these high-risk patients.
Modelling of decay kinetics of self-trapped exciton luminescence in CdWO4 under femtosecond laser excitation in absorption saturation conditions
Authors: Markov Sergey , Nagirnyi Vitali , Vasil’ev Andrey , Makhov Vladimir , Laasner Raul , Vielhauer Sebastian , Kirm Marco , Grigonis Rimantas , Sirutkaitis Valdas 
Published: May 2012

Abstract
The analytical expressions for the three-dimensional spatial distribution of excitons and luminescence decay kinetics of wide band-gap crystals were derived taking into account the saturation effect for absorption near the centre of the incident laser beam with Gaussian transversal profile. The model is verified for the excitonic emission of CdWO4 crystals under excitation by ultra-short laser pulses in the region of weak excitonic absorption.
Investigating the microscopic properties of strongly interacting matter with HADES
Authors: Galatyuk Tetyana , Lorenz Manuel 
Published: May 2012

Abstract
In the energy domain of 1–2 GeV kinetic energy per nucleon, HADES has measured rare and penetrating probes in elementary and heavy ion collisions. Our results demonstrate that electron pair emission in C+C collisions can essentially be explained as a superposition of independent N+N collisions. HADES results on e+e− production in Ar+KCl collisions, however, show a strong enhancement of the dilepton yield relative to a reference spectrum obtained from elementary nucleon-nucleon reactions, signal the onset of medium effects beyond the superposition of individual N+N collisions. Intriguing results where also obtained from the reconstruction of hadrons with open and hidden strangeness. Analyses of the experimentally obtained hadronic yields measured in Ar+KCl allows to extract the chemical freeze-out conditions in the T -µB phase diagram of strongly interacting matter. While the measured abundance of all reconstructed particles are well described assuming thermalization, the also reconstructed double strange baryon ≡− appears about ten times more abundant than expected. This result will be discussed in the context of the exploration of the nuclear matter phase diagram in the region of finite density. Further investigations to search for significant medium effects, will be followed over the coming years with an upgraded HADES detector.
Safety of Infliximab Treatment in Patients with Rheumatoid Arthritis in a Real-world Clinical Setting: Description and Evaluation of Infusion Reactions
Authors: KELSALL JOHN , ROGERS PAMELA , GALINDO GRISELDA , De VERA MARY A. 
Published: May 2012

Objective.To describe acute and delayed infusion reactions in a large cohort of patients with inflammatory arthritis, treated with infliximab (IFX).Methods.We conducted a retrospective chart review of patients treated with IFX at the Mary Pack Arthritis Centre between 2000 and 2008. The primary outcome was the occurrence of acute infusion reactions during infusions or 1–2 hours after each infusion, and secondary outcome was the occurrence of delayed infusion reactions 1–14 days after an infusion. Descriptive analyses were conducted to summarize study outcomes and identify trends over followup.Results.Since 2000, 376 patients were referred to the Mary Pack IFX clinic and 200 received 4399 IFX infusions over a mean 140 ± 132 weeks of followup. Of these, 135 were patients with RA who received 2977 IFX infusions over mean followup of 138 ± 132 weeks. In total 258 episodes of acute reactions were observed for an overall acute reaction rate of 5.8%. Acute infusion reactions were mostly mild (42.6%) and moderate (43.8%) and commonly affected sites were head and neck (31.5%) and cutaneous (21.1%). A total of 37 delayed infusion reaction episodes were observed (0.9% rate); reactions were also mostly mild (16.2%) and moderate (64.9%).Conclusion.These clinical data from 200 patients treated with IFX demonstrate that acute and delayed infusion reactions occur infrequently and are mostly mild to moderate in presentation.
Cigarette Smoking, Alcohol Consumption, and Risk of Systemic Lupus Erythematosus: A Case-control Study in a Japanese Population
Authors: KIYOHARA CHIKAKO , WASHIO MASAKAZU , HORIUCHI TAKAHIKO , ASAMI TOYOKO , IDE SABURO , ATSUMI TATSUYA , KOBASHI GEN , TADA YOSHIFUMI , TAKAHASHI HIROKI ,   Kyushu Sapporo SLE (KYSS) Study Group
Published: May 2012

Objective.Cigarette smoking may be associated with increased risk of systemic lupus erythematosus (SLE), whereas the role of alcohol consumption is unknown. We examined the association between SLE risk and smoking or drinking.Methods.We investigated the relationship of smoking and drinking compared to SLE risk among 171 SLE cases and 492 healthy controls in female Japanese subjects. Unconditional logistic regression was used to compute OR and 95% CI, with adjustments for several covariates.Results.Compared with nonsmoking, current smoking was significantly associated with increased risk of SLE (OR 3.06, 95% CI 1.86–5.03). The higher the level of exposure to cigarette smoke, the higher the risk of SLE. Inhalation was also associated with increased SLE risk (OR 3.73, 95% CI 1.46–9.94 for moderate inhalation; OR 3.06, 95% CI 1.81–5.15 for deep inhalation). In contrast, light/moderate alcohol consumption had a protective effect on SLE risk (OR 0.38, 95% CI 0.19–0.76). As for beer, the risks for non-beer drinkers and beer drinkers were similar. This also applies to alcoholic beverages other than beer.Conclusion.Our results suggest that smoking was positively associated with increased SLE risk whereas light/moderate alcohol consumption was inversely associated with SLE risk, irrespective of the type of alcoholic beverage. Additional studies are warranted to confirm these findings.
Evaluation of a Shared Autoimmune Disease-associated Polymorphism of TRAF6 in Systemic Sclerosis and Giant Cell Arteritis
Authors: CARMONA F. DAVID , SERRANO AURORA , RODRÍGUEZ-RODRÍGUEZ LUIS , CALLEJAS JOSÉ LUIS , SIMEÓN CARMEN P. , CARREIRA PATRICIA , CASTAÑEDA SANTOS , SOLANS ROSER , BLANCO RICARDO ,   The Spanish Scleroderma Group,   The Spanish Giant Cell Arteritis Group, GONZÁLEZ-GAY MIGUEL A. , MARTÍN JAVIER 
Published: May 2012

Objective.We evaluated whether a single-nucleotide polymorphism (SNP) of theTRAF6gene previously associated with systemic lupus erythematosus and rheumatoid arthritis may be a common risk factor for systemic sclerosis (SSc) and giant cell arteritis (GCA).Methods.A total of 1185 patients with SSc, 479 patients with biopsy-proven GCA, and 1442 unrelated healthy controls of white Spanish origin were genotyped for the rs540386 variant using a specifically designed TaqMan©allele discrimination assay.Results.No significant associations of this SNP with global SSc or GCA were found. This was also the case when the potential associations of theTRAF6polymorphism with the main clinical phenotypes of the 2 diseases (e.g., limited cutaneous and diffuse cutaneous SSc, or presence of polymyalgia rheumatica and visual ischemic manifestations in GCA) were assessed.Conclusion.Our data do not support a role of the rs540386TRAF6variant as a key component of the genetic network underlying SSc and GCA.
Vertical Economies and the Costs of Separating Electricity Supply—A Review of Theoretical and Empirical Literature
Authors: Meyer Roland 
Published: May 2012

Motivated by the European movement towards a separation of electricity networks from the competitive functions generation and supply this paper reviews theoretical and empirical literature on vertical synergies in electricity supply. In the analysis a clear distinction is made between four different unbundling options leading to different forms and magnitudes of synergy losses. Apart from coordination economies a main source of scope economies seems to result from a market risk effect if generation and retail are separated. Accordingly, the European policy of network unbundling (either transmission or distribution) results in synergy losses between 2 and 8 percent due to coordination losses, while an unbundling option that includes a separation between retail and generation, as observed in some U.S. states, may lead to a permanent cost increase of 20 percent or more due to a significant risk increase. Keywords: Ownership unbundling, Vertical integration, Economies of scope http://dx.doi.org/10.5547/01956574.33.4.8
Electrode Materials for Rechargeable Sodium‐Ion Batteries: Potential Alternatives to Current Lithium‐Ion Batteries
Authors: Kim Sung‐Wook , Seo Dong‐Hwa , Ma Xiaohua , Ceder Gerbrand , Kang Kisuk 
Published: May 2012

AbstractLithium (Li)‐ion batteries (LIB) have governed the current worldwide rechargeable battery market due to their outstanding energy and power capability. In particular, the LIB's role in enabling electric vehicles (EVs) has been highlighted to replace the current oil‐driven vehicles in order to reduce the usage of oil resources and generation of CO2 gases. Unlike Li, sodium is one of the more abundant elements on Earth and exhibits similar chemical properties to Li, indicating that Na chemistry could be applied to a similar battery system. In the 1970s‐80s, both Na‐ion and Li‐ion electrodes were investigated, but the higher energy density of Li‐ion cells made them more applicable to small, portable electronic devices, and research efforts for rechargeable batteries have been mainly concentrated on LIB since then. Recently, research interest in Na‐ion batteries (NIB) has been resurrected, driven by new applications with requirements different from those in portable electronics, and to address the concern on Li abundance. In this article, both negative and positive electrode materials in NIB are briefly reviewed. While the voltage is generally lower and the volume change upon Na removal or insertion is larger for Na‐intercalation electrodes, compared to their Li equivalents, the power capability can vary depending on the crystal structures. It is concluded that cost‐effective NIB can partially replace LIB, but requires further investigation and improvement.
Design under uncertainty of hydrocarbon biorefinery supply chains: Multiobjective stochastic programming models, decomposition algorithm, and a Comparison between CVaR and downside risk
Authors: Gebreslassie Berhane H. , Yao Yuan , You Fengqi 
Published: May 2012

AbstractA bicriterion, multiperiod, stochastic mixed‐integer linear programming model to address the optimal design of hydrocarbon biorefinery supply chains under supply and demand uncertainties is presented. The model accounts for multiple conversion technologies, feedstock seasonality and fluctuation, geographical diversity, biomass degradation, demand variation, government incentives, and risk management. The objective is simultaneous minimization of the expected annualized cost and the financial risk. The latter criterion is measured by conditional value‐at‐risk and downside risk. The model simultaneously determines the optimal network design, technology selection, capital investment, production planning, and logistics management decisions. Multicut L‐shaped method is implemented to circumvent the computational burden of solving large scale problems. The proposed modeling framework and algorithm are illustrated through four case studies of hydrocarbon biorefinery supply chain for the State of Illinois. Comparisons between the deterministic and stochastic solutions, the different risk metrics, and two decomposition methods are discussed. The computational results show the effectiveness of the proposed strategy for optimal design of hydrocarbon biorefinery supply chain under the presence of uncertainties. © 2012 American Institute of Chemical Engineers AIChE J, 2012
Molecular characterization, recombinant protein expression, and mRNA analysis of type 3 von Willebrand disease: Studies of an Italian cohort of 10 patients
Authors: Solimando Maria , Baronciani Luciano , La Marca Silvia , Cozzi Giovanna , Asselta Rosanna , Canciani Maria Teresa , Federici Augusto B. , Peyvandi Flora 
Published: May 2012

AbstractType 3 von Willebrand disease (VWD3) is characterized by unmeasurable von Willebrand factor (VWF) levels in plasma and platelets and severe but variable hemorrhagic symptoms. To identify and characterize the causal mutations, we screened 10 Italian patients with VWD3 by several techniques including Multiplex Ligation‐dependent Probe Amplification to identify large insertions and deletions, High Resolution Melting and PCR coupled with Sanger sequencing. Fourteen different mutations scattered throughout the VWF gene were identified, 10 of which were novel. As expected, most of these mutations caused null alleles: five were deletions (del exons 1–3, del exon 17, c.2157delA, c.2269delCT, and c.3940delG), three nonsense (p.Q1526X, p.E1549X, and p.C2448X) and three potential splice‐site mutations (c.658‐2A>G, c.7729+7C>T, and c.8155+1G>T). Three candidate missense mutations (p.C2184S, p.C2212R, and p.C2325S) were also identified. Missense mutations and the putative splice‐site defects were confirmed to be disease related by in vitro expression studies and mRNA analysis. None of these patients have developed alloantibodies against VWF. This study extends our previous finding that most of the mutations that we identified in VWD3 patients arise independently and are scattered throughout the entire VWF gene. Am. J. Hematol. 2012. © 2012 Wiley Periodicals, Inc.
Confirmation of the Zechi‐Ceide syndrome
Authors: Patil Siddaramappa J. , Bhat Venkatraman , Dalal Ashwin , Santosh J. Samuel 
Published: May 2012

AbstractAtretic cephaloceles associated with multiple congenital anomalies are known to follow either autosomal dominant or autosomal recessive patterns of inheritance. Zechi‐Ceide syndrome (OMIM 612916) is an autosomal recessive disorder, characterized by an occipital atretic cephalocele, characteristic facial features, and large feet. Here we describe a patient with findings fitting Zechi‐Ceide syndrome, in whom some of the manifestations were also present in his mother, indicating either autosomal dominant inheritance with variable expression, X‐linked inheritance, or a manifesting carrier of an autosomal recessive inheritance. © 2012 Wiley Periodicals, Inc.
Reduced fractional anisotropy in the uncinate fasciculus in patients with major depression carrying the met‐allele of the Val66Met brain‐derived neurotrophic factor genotype
Authors: Carballedo A. , Amico F. , Ugwu I. , Fagan A.J. , Fahey C. , Morris D. , Meaney J.F. , Leemans A. , Frodl T. 
Published: May 2012

AbstractExperimental studies support a neurotrophic hypothesis of major depressive disorder (MDD). The aim of this study was to determine the effect of Val66Met brain‐derived neurotrophic factor (BDNF) polymorphism on the white matter fiber tracts connecting hippocampus and amygdala with the prefrontal lobe in a sample of patients with MDD and healthy controls. Thirty‐seven patients with MDD and 42 healthy volunteers were recruited. Diffusion tensor imaging (DTI) data with 61 diffusion directions were obtained with MRI 3 Tesla scanner. Deterministic tractography was applied with ExploreDTI and Val66Met BDNF SNP (rs6265) was genotyped. Fiber tracts connecting the hippocampus and amygdala with the prefrontal lobe, namely uncinate fasciculus (UF), fornix, and cingulum were analyzed. A significant interaction was found in the UF between BDNF alleles and diagnosis. Patients carrying the BDNF met‐allele had smaller fractional anisotropy (FA) in the UF compared to those patients homozygous for val‐allele and compared to healthy subjects carrying the met‐allele. A significant three‐way interaction was detected between region of the cingulum (dorsal, rostral, and parahippocampal regions), brain hemisphere and BDNF genotype. Larger FA was detectable in the left rostral cingulum for met‐allele carriers when compared to val/val alelle carriers. We provide evidence for the importance of the neurotrophic involvement in limbic and prefrontal connections. The met‐allele of the BDNF polymorphism seems to render subjects more vulnerable for dysfunctions associated with the UF, a tract known to be related to negative emotional–cognitive processing bias, declarative memory problems, and autonoetic self awareness. © 2012 Wiley Periodicals, Inc.
Column adsorption of chromium(VI) by strong alkaline anion‐exchange fiber
Authors: Wang Wenqing , Li Mingyu , Zeng Qingxuan 
Published: May 2012

AbstractThe removal of chromium(VI) from saturated sodium chloride (NaCl) solution by strong alkaline anion‐exchange fiber (SAAEF) was achieved with column experiments. Factors affecting the adsorption, such as the pH value, loading density, flow rate, and operational temperature, were investigated. The results show that Cr(VI) removal was remarkably pH dependent. The optimal operational conditions were as follows: pH value = 2.0, loading density = 0.12–0.19 g/cm3, room temperature, and flow rate = 6–12 BV/h. The SAAEF column could be regenerated completely by 2% NaOH in saturated NaCl or 2% KOH in 15% KCl as an eluent. Cr(VI) was recycled as Na2Cr2O7 and K2Cr2O7, respectively. The desorption rate of Cr(VI) reached 98.09%. The adsorption ability of the SAAEFs was stable after repeated use. Overall, the results indicate that SAAEF proved to be an effective material for the adsorption of high concentrations of Cr(VI) from a saturated NaCl solution. © 2012 Wiley Periodicals, Inc. J Appl Polym Sci, 2012
The influence of mechanical cold drawing and drawing velocity on the molecular structure of isotactic polypropylene fiber
Authors: Sokkar T. Z. N. , El‐Bakary M. A. , Ali A. M. 
Published: May 2012

AbstractThe main goal of this work study is to study the influence of mechanical cold drawing and drawing velocity on the molecular orientation and physical structure parameters of isotactic polypropylene, iPP, fibers. A Video Opto‐ Mechanical device (VOM) attached with automatic multiple‐beam interferometric technique was used to cold draw iPP fibers at different draw ratio and drawing velocity. The molecular structure of iPP fiber was characterized by measuring the refractive indices, birefringence, optical orientation function, orientation angle, the percentage of the volume fraction of amorphous and crystalline regions, density and the mean square density fluctuation. The obtained microinterferograms of multiple beam interference fringes were enhanced and the noises were removed by using Fourier transform method. The obtained contour lines were analyzed via a software program for fiber refractive index determination. The results show that the drawing velocity has a less effect than the draw ratio on the molecular structure of iPP fiber. The contour lines of microinterferograms are given for illustration. © 2012 Wiley Periodicals, Inc. J. Appl. Polym. Sci., 2013
Preparation of core–shell latex for the pigmented ink of textile inkjet printing
Authors: Fu Shaohai , Tian Anli , Du Changsen , Wang Chaoxia 
Published: May 2012

AbstractA core–shell latex comprising poly(butyl acrylate) as core and poly(styrene‐methyl methacrylate) as shell was synthesized by emulsion polymerization using allyloxy nonylphenoxy propanol polyoxyethylene ether ammonium sulfonate (ANPS) as emulsifier. Transmission electron microscope, differential scanning calorimeter, and thermogravimetric analyses suggested the prepared latex had a core–shell structure. The particle size of the core–shell latex was about 102.8 nm with a molar ratio of butylacrylate, methyl methacrylate, and styrene at 6 : 2 : 2, a mass ratio of ANPS and monomers, ammonium persulfate and monomers at 15% and 1.0%, respectively. The core–shell latex showed high centrifugal stability and excellent freeze‐thaw stability. The clogging nozzle rate of the pigmented ink containing 20 wt % core–shell latex was small, whereas the printed fabrics with this pigmented ink exhibited high rub and washing fastness. © 2012 Wiley Periodicals, Inc. J. Appl. Polym. Sci., 2013
Thermal, mechanical, and rheological properties of plasticized poly(L‐lactic acid)
Authors: Ge Huanhuan , Yang Fan , Hao Yanping , Wu Guangfeng , Zhang Huiliang , Dong Lisong 
Published: May 2012

AbstractPolylactide (PLA) is an attractive candidate for replacing petrochemical polymers because it is biodegradable. In this study, a specific PLA 2002D was melt‐mixed with a new plasticizer: glycerol monostearate (GMS). The PLA/GMS blends with different ratios were analyzed by dynamic mechanical analysis and differential scanning calorimetry. Although a slightly phase separation can be seen in DSC curves, the SEM micrographs of the impact fracture surfaces of PLA/GMS blends had a relatively good separation and this phenomenon was in good agreement with their higher impact strength. The result showed that the adding of GMS has enhanced the flexibility of PLA/GMS blends as compared to neat PLA. The relationship between complex viscosity and angular frequency of the PLA/GMS blends exhibits that the melt viscosity substantially lower than that of neat PLA. For example, at 10 rad/s, the melt viscosity of PLA/GMS (85/15) was reduced by about 7.2% compared to that of neat PLA. The impact strength was changed from 4.7 KJ/m2 for neat PLA to 48.2 KJ/m2 for 70/30 PLA/GMS blend. © 2012 Wiley Periodicals, Inc. J. Appl. Polym. Sci., 2013