bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of aqueous extract of olea europea l. plant in biochemical , oxidation parametrs in male rats treated with cyclophosphamide
Authors: ابراهيم احسان ريسان 
Published: May 2024

This study was conducted to determine the role of extract of Olea europea L. to reduce the negative effects of cyclophosphamide in some biochemical, oxidation aspects. male rats divided into three groups first group injectedwith distilled water was given ip. The second group injected ip with cyclophosphamide at dose (50 mg / kg) for 14 days the third group was given also drug with the dose (50 mg / kg) for 14 days then treated animals were given extract at dose (300 mg / kg) for 14 days. Samples of blood were collected and isolated serum , the parameters in study were included lipid profile (total cholesterol ,high density lipoprotien ,low density lipoprotien and triglycerides) ,enzymes( GPT, GOT, ALP)and glucose also included anti-oxidant(Glutathione) and lipid peroxidation (Malondialdehayde). Results showed a significant increase in enzymes (GPT, GOT, ALP), LDL, total cholesterol, triglyceride and malondialdehyde in while appear significant decrease in glutathione, glucose and HDL in drug injected group compared with the control group. While the extract treatment group caused decreased significantly in enzymes (GPT, GOT, ALP), LDL, TG, Cholesterol and Malondialdehayde, while show results increase in glutathione, glucose and HDL compared with drug injected group. concluded the ability of aqueous extract of Olea europea L. to reduce some of the negative effects of drug cyclophosphamide in white rats.
OPTIMALISASI PENGEMBANGAN USAHA JAMUR TIRAM PADA KELOMPOK TANI JAMUR DI DESA SIBANG GEDE KABUPATENG BADUNG
Authors: Sudiartini Ni Wayan Ari , Saravistha Deli Bunga , Arwini Ni Putu Decy 
Published: May 2024

Oyster mushrooms are an edible mushroom that are liked by the public because it has a delicious taste and high nutritional value. Oyster mushrooms can be cultivated in a medium (Baglog) which comes from wood dust or lignin material that has been rotted wrapped in plastic and sterilized. The raw material for wood powder is increasingly difficult to obtain due to the reduced use of wood, which causes the price of sawdust to increase and the cost of mushroom production will increase. increase. Mushrooms are one of the exports and domestic consumption commodities that can be made into food with a high taste. The relatively expensive price of mushrooms makes mushroom farmers try to increase their production so they can meet consumer needs. One thing that needs to be addressed is the problem of mushroom breeding. The problem experienced by the Double U Mushroom business is the machine used to make baglog, the machine that must be prepared is the baglog mixing machine itself. Meanwhile, currently, we still buy backlog from collectors for IDR 3,000 – IDR. 3,100 so the profit is very minimal. By increasing mushroom production through the procurement of baglog mixing machines, it is hoped that the Mushroom Business can be optimized and reduce baglog purchasing costs. The marketing of Double U Mushroom has reached both modern traders and traditional traders. The increase in production is also balanced with improvements to the product brand/logo at the Double U Mushroom Business which will be designed with attractive images, colors, and layout so that potential consumers are more interested in buying Double U Mushroom mushrooms by looking at the product logo.
Educación inclusiva desde un enfoque diferencial y de género: a propósito de los gestos y el tacto pedagógico en un contexto migratorio
Authors: Rodríguez Gómez Hilda Mar , Restrepo Gil Andrés , Villalba Mojica Laura 
Published: May 2024

Este artículo es una elaboración en el marco del proyecto de investigación Venezuelan migrant students in public schools in Medellín. An anthropological analysis of possibilities and constraints of an inclusive education for all in a new international migration context, que desarrollan la Universidad Pedagógica de Berna y la Universidad de Antioquia, con el apoyo financiero de la St. Gallen University. En este proyecto, además de los autores de este artículo, participan: Angela Stienen, Stefanie Strülik y Luisa Genovese de la ph Bern, y Juan Camilo Estrada y Yólida Ramírez de la udea. Este artículo analiza, desde un enfoque de género, los gestos y el tacto pedagógico que dan forma a las prácticas inclusivas de una escuela de Medellín, Colombia. Para ello, hacemos una presentación de la escuela en cuestión, la Institución Educativa Héctor Abad Gómez, así como de los principios que orientan sus prácticas pedagógicas. Analizamos lo que esta institución entiende por inclusión, así como los acercamientos y las propuestas que, desde el Ministerio de Educación Nacional, se hacen de este concepto. Presentamos la metodología que nos ha permitido recoger y analizar la información. Subsiguientemente, exploramos la noción de tacto pedagógico y analizamos, desde un enfoque de género, cómo este tacto se materializa en ciertos gestos de cuidado en esta escuela. Cerramos el texto con la conclusión de que esta institución y sus maestras generan un esfuerzo genuino por adoptar gestos de tacto pedagógico y cuidado en el marco de una realidad que violenta y vulnera los derechos de aquellas personas excluidas del privilegio del sistema socio-político dominante. El presente artículo es resultado de una investigación realizada en el marco de una cooperación entre la Universidad Pedagógica de Berna en Suiza y la Universidad de Antioquia en Colombia, que indaga por las transformaciones que ha adoptado la Institución Educativa Héctor Abad Gómez para la inclusión de migrantes venezolanos y de otras identidades que llegan a esta escuela: población indígena, afro y negra, personas en situación de desplazamiento.
Las TIC en la enseñanza del inglés para la educación básica: una revisión sistemática
Authors: Yánez-Goyes María , Peñaherrera-Solarte Karina , Carlín-Chávez Esther , Bonilla-Tenesaca Josué 
Published: May 2024

En este artículo se ha investigado acerca de la integración de las TIC en la Educación Básica para mejorar la enseñanza del idioma inglés. Esto ha permitido obtener información significativa al relacionar los conocimientos con la realidad, por lo cual se ha considerado importante indagar sobre el uso de las TIC en este proceso. Se ha realizado una revisión documental de carácter cualitativa-descriptiva, no experimental.
Para la búsqueda sistemática se han utilizado diferentes bases de datos como: Scielo, Google Académico, Redalyc, La Referencia, Dialnet y Refseek. Entre los resultados se ha destacado que de un total de 100 artículos y luego de una rigurosa filtración, se obtuvieron 33 artículos válidos para esta investigación, los cuales cumplen con los estándares establecidos en la selección. Los resultados han revelado que las TIC son herramientas efectivas para mejorar el aprendizaje del inglés, ya que proporcionan recursos interactivos y motivadores para los estudiantes. Sin embargo, también se han identificado desafíos en la implementación de las TIC, como la falta de capacitación docente y el acceso limitado a la tecnología en algunas escuelas, por lo que se sugiere que se promueva la capacitación docente y se garantice el acceso a las TIC para aprovechar su potencial en la enseñanza del inglés en la educación básica.

Palabras clave: TIC, enseñanza de idiomas, educación básica, inglés
Diseño modelo de estrategias de marketing digital en redes sociales para las tiendas de barrio en el cantón santa elena 2024
Authors: Chuquimarca-Ramírez José , Santamaria-Manobanda Geovanny 
Published: May 2024

En este estudio abordaremos el diseño modelo de estrategias de marketing digital para lograr el posicionamiento en redes sociales de las tiendas de barrio, se identificará la red social más adecuada para la aplicación de estrategias de marketing, de modo que nuestro Objetivo General es, Diseñar un modelo de estrategias de marketing digital en redes sociales para el posicionamiento de las tiendas de barrio. Teniendo como objetivo específico analizar las estrategias de marketing digital en redes sociales y fundamentarlas teóricamente con el fin de encontrar su efectividad para su aplicación de forma que nos permita, describir la situación actual de las tiendas de barrio, para la fijación de estrategias de marketing adecuadas. A su vez, Diseñar un modelo de estrategias de marketing digital en redes sociales para lograr posicionar a las tiendas de barrio. definiendo la metodología a utilizar es una investigación mixta cualitativa y cuantitativa a nivel descriptivo, se establece la utilización del método análisis sintético, con la utilización de instrumentos como la encuesta y entrevistas a profundidad, de manera que los resultados estarán enfocados en definir la red social más adecuada para el posicionamiento de las tiendas de barrio, para su proceso de adaptación a los entornos digitales. Concluyendo en términos generales la importancia de que los negocios se involucren, se capaciten para afrontar nuevos desafíos con los avances tecnológicos en temas relacionados a comercios digitales.
Palabras claves: posicionamiento, redes sociales, estrategias, tiendas, barrios
Penerapan Metode Mikir Dalam Menulis Naskah Drama Pada Siswa Kelas X MIPA 1 SMAN 7 Soppeng
Authors: Herniyastuti Herniyastuti , Ebe Andi , Umar Ratnawati , Nurcaya Nurcaya 
Published: May 2024

Penelitian ini dilatarbelakangi oleh kemampuan siswa dalam menulis naskah drama yang masih relatif rendah akibat tidak ada variasi strategi pembelajaran dan kurangnya motivasi peseerta didik dalam menulis sehingga keterampilan menulis naskah drama belum memenuhi kriteria ketuntasan minimal (KKM). Tujuan dari penelitian ini adalah untuk meningkatkan keterampilan menulis naskah drama melalui metode MIKIR pada siswa kelas X MIPA 1 SMA Negeri 3 Sengkang. Jenis penelitian ini adalah Penelitian Tindakan Kelas (PTK). Penelitian ini dilaksanakan melalui dua siklus dengan setiap siklus terdiri atas empat tahap yaitu perencanaan, pelaksanaan, pengamatan, dan refleksi. Penelitian ini dilaksanakan dalam kurun waktu tiga bulan yaitu bulan Agustus hingga Oktober 2022. Menggunakan teknik tes dan non-tes dalam pengumpulan datanya serta menggunakan teknik analisis kualitatif dan kuantitatif dalam menganalisis data penelitian.Hasil penelitian menunjukkan peningkatan penilaian tugas menulis naskah drama dari 47,35% pada siklus I menjadi 76,47% pada siklus II, dari penilaian keterampilan menulis naskah drama dengan skor rata-rata 2 pada siklus I menjadi 4 pada siklus II, dan dari ketuntasan belajar 50% pada siklus I menjadi 94,12% pada siklus II merupakan bukti keberhasilan penggunaan metode MIKIR dalam meningkatkan keterampilan menulis naskah drama pada siswa kelas X MIPA 1 SMAN 7 Soppeng.
Model Project Based Learning Berbantuan Media Sosial Instagram Reels Dalam Pembelajaran Menulis Teks Prosedur
Authors: Simamora Sri Arliyanti , Isah Cahyani  , Khaerudin Kurniawan  
Published: May 2024

Penelitian ini dilatarbelakangi rendahnya kemampuan menulis teks prosedur siswa SMA Kota Bandung dan Kabupaten Bandung Barat. Salah satu faktor penyebabnya adalah guru kurang baik dalam merancang model pembelajaran yang efektif. Penelitian ini bertujuan untuk menghasilkan model pembelajaran sesuai dengan kebutuhan, situasi, dan kondisi peserta didik dan pendidik. Metode penelitian yang digunakan dalam penelitian ini yaitu adaptasi dari metode penelitian dan pengembangan Sukmadinata (2016) yang terdiri atas tiga tahapan yaitu (1) studi pendahuluan, (2) pengembangan model, dan (3) pengujian model. Teknik pengumpulan data yang digunakan adalah observasi, wawancara, dan penyebaran angket. Uji kelayakan model pembelajaran divalidasi oleh 11 orang ahli, dengan skor rata-rata 96% dengan kategori sangat baik dan layak diujicobakan. Keefektifan pengembangan model pembelajaran project based learning berbantuan media sosial instagram reels dinilai efektif dalam pembelajaran menulis teks prosedur. Berdasarkan Hasil perhitungan nilai ratarata N-Gain score kelas eksperimen pada uji luas dengan menggunakan model pembelajaran project based learning berbantuan media sosial instagram reels adalah sebesar 84,48% termasuk kategori efektif, sedangkan keterpakaian model pembelajaran diperoleh berdasarkan respons peserta didik melalui angket menunjukkan 96% siswa merasa pembelajaran menulis teks prosedur dengan model pembelajaran ini sangat menarik karena dapat langsung membantu siswa untuk mengetahui cara yang tepat menulis teks prosedur sesuai struktur dan kaidah kebahasaan serta mempublikasikannya. Selanjutnya hasil respons angket guru secara kumulatif seluruh aspek memperoleh skor rata-rata adalah 49 setara dengan 97% dengan kategori sangat baik. Dengan demikian dapat disimpukan bahwa model pembelajaran project based learning berbantuan media sosial instagram reels dalam pembelajaran menulis teks prosedur layak diterapkan.
Crosstalk between human immunodeficiency virus infection and salivary bacterial function in men who have sex with men
Authors: Guo Ying , Wang Wenjing , Yu Yixi , Sun Xintong , Zhang Baojin , Wang Yan , Cao Jie , Wen Shuo , Wang Xin , Li Yuchen , Cai Siyu , Wu Ruojun , Duan Wenshan , Xia Wei , Wei Feili , Duan Junyi , Dong Haozhi , Guo Shan , Zhang Fengqiu , Sun Zheng , Huang Xiaojie 
Published: May 2024

BackgroundEngaging in anal sexual intercourse markedly increases the risk of developing HIV among men who have sex with men (MSM); oral sexual activities tend to uniquely introduce gut-derived microbes to salivary microbiota, which, combined with an individual’s positive HIV status, may greatly perturb oral microecology. However, till date, only a few published studies have addressed this aspect.MethodsBased on 16S rRNA sequencing data of bacterial taxa, MicroPITA picks representative samples for metagenomic analysis, effectively revealing how the development and progression of the HIV disease influences oral microbiota in MSM. Therefore, we collected samples from 11 HIV-negative and 44 HIV-positive MSM subjects (stage 0 was defined by HIV RNA positivity, but negative or indeterminate antibody status; stages 1, 2, and 3 were defined by CD4+ T lymphocyte counts ≥ 500, 200–499, and ≤ 200 or opportunistic infection) and selected 25 representative saliva samples (5 cases/stage) using MicroPITA. Metagenomic sequencing analysis were performed to explore whether positive HIV status changes salivary bacterial KEGG function and metabolic pathway in MSM.ResultsThe core functions of oral microbiota were maintained across each of the five groups, including metabolism, genetic and environmental information processing. All HIV-positive groups displayed KEGG functions of abnormal proliferation, most prominently at stage 0, and others related to metabolism. Clustering relationship analysis tentatively identified functional relationships between groups, with bacterial function being more similar between stage 0-control groups and stage 1-2 groups, whereas the stage 3 group exhibited large functional changes. Although we identified most metabolic pathways as being common to all five groups, several unique pathways formed clusters for certain groups; the stage 0 group had several, while the stage 2 and 3 groups had few, such clusters. The abundance of K03046 was positively correlated with CD4 counts.ConclusionAs HIV progresses, salivary bacterial function and metabolic pathways in MSM progressively changes, which may be related to HIV promoting abnormal energy metabolism and exacerbate pathogen virulence. Further, infection and drug resistance of acute stage and immune cell destruction of AIDS stage were abnormally increased, predicting an increased risk for MSM individuals to develop systemic and oral diseases.
Androgen levels in autism spectrum disorders: a systematic review and meta-analysis
Authors: Wang Zhao , Zhang Bohan , Mu Chenyu , Qiao Dan , Chen Huan , Zhao Yan , Cui Huixian , Zhang Rong , Li Sha 
Published: May 2024

BackgroundAccumulating evidence suggests that the autism spectrum disorder (ASD) population exhibits altered hormone levels, including androgens. However, studies on the regulation of androgens, such as testosterone and dehydroepiandrosterone (DHEA), in relation to sex differences in individuals with ASD are limited and inconsistent. We conducted the systematic review with meta-analysis to quantitatively summarise the blood, urine, or saliva androgen data between individuals with ASD and controls.MethodsA systematic search was conducted for eligible studies published before 16 January 2023 in six international and two Chinese databases. We computed summary statistics with a random-effects model. Publication bias was assessed using funnel plots and heterogeneity using I2 statistics. Subgroup analysis was performed by age, sex, sample source, and measurement method to explain the heterogeneity.Results17 case-control studies (individuals with ASD, 825; controls, 669) were assessed. Androgen levels were significantly higher in individuals with ASD than that in controls (SMD: 0.27, 95% CI: 0.06–0.48, P=0.01). Subgroup analysis showed significantly elevated levels of urinary total testosterone, urinary DHEA, and free testosterone in individuals with ASD. DHEA level was also significantly elevated in males with ASD.ConclusionAndrogen levels, especially free testosterone, may be elevated in individuals with ASD and DHEA levels may be specifically elevated in males.
Interstitial macrophage phenotypes in Schistosoma-induced pulmonary hypertension
Authors: Kumar Rahul , Kumar Sushil , Mickael Claudia , Fonseca Balladares Dara , Nolan Kevin , Lee Michael H. , Sanders Linda , Nilsson Julia , Molofsky Ari B. , Tuder Rubin M. , Stenmark Kurt R. , Graham Brian B. 
Published: May 2024

BackgroundSchistosomiasis is a common cause of pulmonary hypertension (PH) worldwide. Type 2 inflammation contributes to the development of Schistosoma-induced PH. Specifically, interstitial macrophages (IMs) derived from monocytes play a pivotal role by producing thrombospondin-1 (TSP-1), which in turn activates TGF-β, thereby driving the pathology of PH. Resident and recruited IM subpopulations have recently been identified. We hypothesized that in Schistosoma-PH, one IM subpopulation expresses monocyte recruitment factors, whereas recruited monocytes become a separate IM subpopulation that expresses TSP-1.MethodsMice were intraperitoneally sensitized and then intravenously challenged with S. mansoni eggs. Flow cytometry on lungs and blood was performed on wildtype and reporter mice to identify IM subpopulations and protein expression. Single-cell RNA sequencing (scRNAseq) was performed on flow-sorted IMs from unexposed and at day 1, 3 and 7 following Schistosoma exposure to complement flow cytometry based IM characterization and identify gene expression.ResultsFlow cytometry and scRNAseq both identified 3 IM subpopulations, characterized by CCR2, MHCII, and FOLR2 expression. Following Schistosoma exposure, the CCR2+ IM subpopulation expanded, suggestive of circulating monocyte recruitment. Schistosoma exposure caused increased monocyte-recruitment ligand CCL2 expression in the resident FOLR2+ IM subpopulation. In contrast, the vascular pathology-driving protein TSP-1 was greatest in the CCR2+ IM subpopulation.ConclusionSchistosoma-induced PH involves crosstalk between IM subpopulations, with increased expression of monocyte recruitment ligands by resident FOLR2+ IMs, and the recruitment of CCR2+ IMs which express TSP-1 that activates TGF-β and causes PH.
Working memory and inhibitory control deficits in children with ADHD: an experimental evaluation of competing model predictions
Authors: Kofler Michael J. , Groves Nicole B. , Chan Elizabeth S. M. , Marsh Carolyn L. , Cole Alissa M. , Gaye Fatou , Cibrian Enrique , Tatsuki Miho O. , Singh Leah J. 
Published: May 2024

IntroductionChildren with ADHD demonstrate difficulties on many different neuropsychological tests. However, it remains unclear whether this pattern reflects a large number of distinct deficits or a small number of deficit(s) that broadly impact test performance. The current study is among the first experiments to systematically manipulate demands on both working memory and inhibition, with implications for competing conceptual models of ADHD pathogenesis. MethodA clinically evaluated, carefully phenotyped sample of 110 children with ADHD, anxiety disorders, or co-occurring ADHD+anxiety (Mage=10.35, 44 girls; 69% White Not Hispanic/Latino) completed a counterbalanced, double dissociation experiment, with two tasks each per inhibition (low vs. high) x working memory (low vs. high) condition. ResultsBayesian and frequentist models converged in indicating that both manipulations successfully increased demands on their target executive function (BF10&gt;5.33x108, p&lt;.001). Importantly, occupying children’s limited capacity working memory system produced slower response times and reduced accuracy on inhibition tasks (BF10&gt;317.42, p&lt;.001, d=0.67-1.53). It also appeared to differentially reduce inhibition (and non-inhibition) accuracy for children with ADHD relative to children with anxiety (BF10=2.03, p=.02, d=0.50). In contrast, there was strong evidence against models that view working memory deficits as secondary outcomes of underlying inhibition deficits in ADHD (BF01=18.52, p=.85).DiscussionThis pattern indicates that working memory broadly affects children’s ability to inhibit prepotent tendencies and maintain fast/accurate performance, and may explain the errors that children with ADHD make on inhibition tests. These findings are broadly consistent with models describing working memory as a causal mechanism that gives rise to secondary impairments. In contrast, these findings provide evidence against models that view disinhibition as a cause of working memory difficulties or view working memory as a non-causal correlate or epiphenomenon in ADHD.