bluuebunny/crossref_metadata_2025_split huggingface dataset:
Oral health in youth with visual impairment: A longitudinal survey
Authors: Křížová Petra , Himmlová Lucie , Chramosta Petr , Vařejčko David , Vašáková Jana , Urbanová Wanda 
Published: May 2024

AbstractThis longitudinal survey aims to demonstrate improvement in oral hygiene among a group of youth with visual impairment (VI) achieved by repeated oral hygiene training, compare their progress with healthy peers (CG) and assess their oral health knowledge. In 100 VI (55♀, 45♂; ± 17.8 years) and 45 CG (23♀, 22♂; ± 17.2 years) oral hygiene training and a Quigley-Hein Plaque Index (QHI) rating were repeated six times at three-month intervals. The VI were divided into four subgroups according to the toothbrush hardness/type. A questionnaire was given to both groups. Appropriate statistical analyses were performed at 5% significance level. Both groups showed reduction in QHI, the VI had overall higher QHI values than CG. Use of an electric toothbrush in VI led to lower QHI in the last examination (p < 0.03). 69% of participants recommended dental specialists to improve communications by acquiring more illustrative aids. VI changed toothbrush less often (p < 0.02). A higher incidence of dental plaque was confirmed in VI compared to CG. After education and individual training, gradual plaque reduction has occurred in both groups. Using an electric toothbrush in VI resulted in better QHI outcomes. Repetitive preventive intervention in youth with VI helped them to adopt healthier oral hygiene habits.
Association between atherosclerotic cardiovascular disease score and skin carotenoid levels estimated via refraction spectroscopy in the Japanese population: a cross-sectional study
Authors: Obana Akira , Nakamura Mieko , Miura Ayako , Nozue Miho , Muto Shigeki , Asaoka Ryo 
Published: May 2024

AbstractCarotenoids play a role in preventing and impeding the progression of atherosclerotic cardiovascular diseases (ASCVDs) through their anti-oxidative effects. This study evaluated associations between ASCVD risk and skin carotenoid (SC) levels, reflecting dietary carotenoid intake. Participants’ ASCVD risk was assessed using the Hisayama ASCVD risk prediction model, and SC levels were measured through a reflection spectroscope (Veggie Meter). The associations between high ASCVD risk and SC levels were analyzed using logistic regression analysis and a restricted cubic spline (RCS) model. A total of 1130 men and women (mean age: 56 years) from participants who underwent a health examination in Seirei Center for Health Promotion and Prevention Medicine in 2019 and 2022 were analyzed. Of these, 4.6% had moderate or high ASCVD risk. Mean SC values were 236, 315, 376, 447, and 606 in quintile Q1 to Q5, respectively. The adjusted odds ratios (95% confidence intervals) of SC quintile for moderate- or high-risk ASCVD was 0.24 (0.12–0.51) in Q5 (495 ≤), 0.42 (0.23–0.77) in Q4, 0.50 (0.29–0.88) in Q3, and 0.68 (0.41–1.12) in Q2 compared to Q1 (< 281). High SC values continuously showed non-linear inverse association with moderate- or high-risk for ASCVD in Japanese adults. Non-invasive SC measurements may be a good indicator for recommending carotenoids to prevent cardiovascular disease.
In vivo phage display identifies novel peptides for cardiac targeting
Authors: Ivanova Alena , Kohl Franziska , González-King Garibotti Hernán , Chalupska Renata , Cvjetkovic Aleksander , Firth Mike , Jennbacken Karin , Martinsson Sofia , Silva Andreia M. , Viken Ida , Wang Qing-Dong , Wiseman John , Dekker Niek 
Published: May 2024

AbstractHeart failure remains a leading cause of mortality. Therapeutic intervention for heart failure would benefit from targeted delivery to the damaged heart tissue. Here, we applied in vivo peptide phage display coupled with high-throughput Next-Generation Sequencing (NGS) and identified peptides specifically targeting damaged cardiac tissue. We established a bioinformatics pipeline for the identification of cardiac targeting peptides. Hit peptides demonstrated preferential uptake by human induced pluripotent stem cell (iPSC)-derived cardiomyocytes and immortalized mouse HL1 cardiomyocytes, without substantial uptake in human liver HepG2 cells. These novel peptides hold promise for use in targeted drug delivery and regenerative strategies and open new avenues in cardiovascular research and clinical practice.
SARS-CoV-2 detection in pediatric dental clinic wastewater reflects the number of local COVID-19 cases in children under 10 years old
Authors: Kanamori Dai , Sakai Jun , Iijima Takahiro , Oono Yuka , Malla Bikash , Haramoto Eiji , Hayakawa Satoshi , Komine-Aizawa Shihoko , Maesaki Shigefumi , Vorup-Jensen Thomas , Kilgore Paul Evan , Kohase Hikaru , Hoshino Tomonori , Seki Mitsuko 
Published: May 2024

AbstractThis was the first longitudinal study to analyze dental clinic wastewater to estimate asymptomatic SARS-CoV-2 infection trends in children. We monitored wastewater over a 14-month period, spanning three major COVID-19 waves driven by the Alpha, Delta, and Omicron variants. Each Saturday, wastewater was sampled at the Pediatric Dental Clinic of the only dental hospital in Japan’s Saitama Prefecture. The relationship between the weekly number of cases in Saitama Prefecture among residents aged < 10 years (exposure) and wastewater SARS-CoV-2 RNA detection (outcome) was examined. The number of cases was significantly associated with wastewater SARS-CoV-2 RNA positivity (risk ratio, 5.36; 95% confidence interval, 1.72–16.67; Fisher’s exact test, p = 0.0005). A sample from Week 8 of 2022 harbored the Omicron variant. Compared to sporadic individual testing, this approach allows continuous population-level surveillance, which is less affected by healthcare seeking and test availability. Since wastewater from pediatric dental clinics originates from the oral cavities of asymptomatic children, such testing can provide important information regarding asymptomatic COVID-19 in children, complementing clinical pediatric data.
Numerical simulation of the influence of nasal cycle on nasal airflow
Authors: Wei Jing , He Xuan , Yang Qing , Gu Qifei , Zhang Xiaodan , Sui Xue , Zhou Rui , Feng Wei 
Published: May 2024

AbstractTo study the characteristics of nasal airflow in the presence of nasal cycle by computational fluid dynamics. CT scan data of a healthy Chinese individual was used to construct a three-dimensional model of the nasal cavity to be used as simulation domain. A sinusoidal airflow velocity is set at the nasal cavity entrance to reproduce the breathing pattern of a healthy human. There was a significant difference in the cross-sectional area between the two sides of the nasal cavity. Particularly, the decongested side is characterized by a larger cross-section area, and consequently, by a larger volume with respect to the congested side. The airflow velocity, pressure, and nasal resistance were higher on the congested narrow side. The temperature regulation ability on the congested narrow side was stronger than that on the decongested wider side. During the nasal cycle, there are differences in the nasal cavity function between the congested and decongested sides. Therefore, when evaluating the impact of various factors on nasal cavity function, the nasal cycle should be considered.
Expression and potential molecular mechanism of TOP2A in metastasis of non-small cell lung cancer
Authors: Wu Jiatao , Li Wenjuan , Zhang Xueying , Shi Fan , Jia Qianhao , Wang Yufei , Shi Yuqi , Wu Shiwu , Wang Xiaojing 
Published: May 2024

AbstractDNA topoisomerase II alpha (TOP2A) expression, gene alterations, and enzyme activity have been studied in various malignant tumors. Abnormal elevation of TOP2A expression is considered to be related to the development of non-small cell lung cancer (NSCLC). However, its association with tumor metastasis and its mode of action remains unclear. Bioinformatics, real-time quantitative PCR, immunohistochemistry and immunoblotting were used to detect TOP2A expression in NSCLC tissues and cells. Cell migration and invasion assays as well as cytoskeletal staining were performed to analyze the effects of TOP2A on the motility, migration and invasion ability of NSCLC cells. Cell cycle and apoptosis assays were used to verify the effects of TOP2A on apoptosis as well as cycle distribution in NSCLC. TOP2A expression was considerably upregulated in NSCLC and significantly correlated with tumor metastasis and the occurrence of epithelial–mesenchymal transition (EMT) in NSCLC. Additionally, by interacting with the classical ligand Wnt3a, TOP2A may trigger the canonical Wnt signaling pathway in NSCLC. These observations suggest that TOP2A promotes EMT in NSCLC by activating the Wnt/β-catenin signaling pathway and positively regulates malignant events in NSCLC, in addition to its significant association with tumor metastasis. TOP2A promotes the metastasis of NSCLC by stimulating the canonical Wnt signaling pathway and inducing EMT. This study further elucidates the mechanism of action of TOP2A, suggesting that it might be a potential therapeutic target for anti-metastatic therapy.
Study on the critical stable height of vertical excavation in rocky foundation pit within layered structural plane
Authors: Zhang Ziguang , You Xueping , Zhang Cheng , Li Wanyu , Zhang Mengqing 
Published: May 2024

AbstractThe structural plane characteristic was the most critical factor for determining the self-stability ability of deep foundation pit vertical-rock-wall in layered rock stratum. Multiple methods such as model testing, numerical calculation, and theoretical calculation were utilized comprehensively in this paper. The self-stabilizing control effect on the deep foundation pits vertical-rock-wall that under the different structural plane inclination angle (α) and under the different structural plane strength was systematically studied. The results indicated that the overall variation trend of "Sharp decrease ~ Slow decrease ~ Slow increase ~ Sharp increase" in the symmetrical distribution for the self-stability critical height (Hcr) varied with the gradually increasing of α was presented. Meanwhile, the variation trend of "continuously decreasing and rapidly decreasing first, and then slowly decreasing and tending to stabilize" with the structural plane strength reduction coefficient (k). The key factor to control the self-stability of the deep foundation pit vertical-rock-walls lied in fully grasping and utilizing the basic characteristics of rock structural planes. The research results of this paper provided the theoretical basis for scientifically determining the safety level and designing reasonable support structures of the deep foundation pit vertical-rock-walls in layered rock stratum.
Deep-learning-based pelvic automatic segmentation in pelvic fractures
Authors: Lee Jung Min , Park Jun Young , Kim Young Jae , Kim Kwang Gi 
Published: May 2024

AbstractWith the recent increase in traffic accidents, pelvic fractures are increasing, second only to skull fractures, in terms of mortality and risk of complications. Research is actively being conducted on the treatment of intra-abdominal bleeding, the primary cause of death related to pelvic fractures. Considerable preliminary research has also been performed on segmenting tumors and organs. However, studies on clinically useful algorithms for bone and pelvic segmentation, based on developed models, are limited. In this study, we explored the potential of deep-learning models presented in previous studies to accurately segment pelvic regions in X-ray images. Data were collected from X-ray images of 940 patients aged 18 or older at Gachon University Gil Hospital from January 2015 to December 2022. To segment the pelvis, Attention U-Net, Swin U-Net, and U-Net were trained, thereby comparing and analyzing the results using five-fold cross-validation. The Swin U-Net model displayed relatively high performance compared to Attention U-Net and U-Net models, achieving an average sensitivity, specificity, accuracy, and dice similarity coefficient of 96.77%, of 98.50%, 98.03%, and 96.32%, respectively.
Detecting lies in investigative interviews through the analysis of response latencies and error rates to unexpected questions
Authors: Melis Giulia , Ursino Martina , Scarpazza Cristina , Zangrossi Andrea , Sartori Giuseppe 
Published: May 2024

AbstractIn this study, we propose an approach to detect deception during investigative interviews by integrating response latency and error analysis with the unexpected question technique. Sixty participants were assigned to an honest (n = 30) or deceptive group (n = 30). The deceptive group was instructed to memorize the false biographical details of a fictitious identity. Throughout the interviews, participants were presented with a randomized sequence of control, expected, and unexpected open-ended questions about identity. Responses were audio recorded for detailed examination. Our findings indicate that deceptive participants showed markedly longer latencies and higher error rates when answering expected (requiring deception) and unexpected questions (for which premeditated deception was not possible). Longer response latencies were also observed in participants attempting deception when answering control questions (which necessitated truthful answers). Moreover, a within-subject analysis highlighted that responding to unexpected questions significantly impaired individuals’ performance compared to answering control and expected questions. Leveraging machine-learning algorithms, our approach attained a classification accuracy of 98% in distinguishing deceptive and honest participants. Additionally, a classification analysis on single response levels was conducted. Our findings underscore the effectiveness of merging response latency metrics and error rates with unexpected questioning as a robust method for identity deception detection in investigative interviews. We also discuss significant implications for enhancing interview strategies.
Multiple pulmonary sclerosing pneumocytoma, based on a study of 36 cases worldwide
Authors: He Pan , Wang Jianwei , Guo Jiong , Li Shunqi , Zhang Weidong 
Published: May 2024

AbstractTo analyze the clinical characteristics and to improve clinicians’ understanding of multiple pulmonary sclerosing pneumocytoma (PSP) patients. A total of 36 PSP patients with multiple tumor characteristics were identified from the literature search. They were compared with 43 solitary PSP patients diagnosed and treated in our hospital in the past 5 years. Thus, the pathogenesis, clinical symptoms, diagnosis methods, treatment strategies, and prognosis of pulmonary sclerosing pneumocytoma (PSP) patients with multiple tumors were explored. Patients with multiple PSP are mostly distributed in Asia (88.89%) and are females (83.33%). PSP can be located in any one lobe (19.44%), or grow across ipsilateral lobes (44.44%), or even, bilateral lobes (36.11%). It can be accompanied by metastasis (9.09%) and is prone to misdiagnosis (27.78%). Compared with solitary PSP, the occurrence age of multiple PSP was younger (mean ± standard deviation [SD]: 40.36 ± 18.12: 51.28 ± 12.74 years), but there was no significant difference in sex, tumor size (mean ± SD: 43.54 ± 46.18: 30.56 ± 17.62 mm), or symptoms. Individualized surgical resection is required for treatment, including pneumonectomy (17.65%), lobectomy (23.53%), subpulmonary lobectomy (38.24%), or combined lobectomy (5.88%). Multiple PSP is relatively rare. Surgical resection within a limited time should be the main treatment for such patients. The prognosis of patients with multiple PSP is generally good, but inappropriate diagnosis and treatment plans may lead to poor prognosis.
Developing a nomogram based on SEER database for predicting prognosis in choroid plexus tumors
Authors: Yang Zedi , Jiang Heng , He Ding , Zhang Sheng , Huang Lei , Gao Peigeng , Huang Haiyan , Cao Junguo , Zhan Zhixin 
Published: May 2024

AbstractChoroid plexus tumors (CPT) are rare and highly vascularized neoplasms that have three histologically confirmed diagnoses, including choroid plexus papilloma, atypical choroid plexus papilloma, and choroid plexus carcinoma (CPC). This study aimed to determine the epidemiology and survival of patients with CPTs and develop a nomogram to quantify the prognosis of the patients with CPT. Data of 808 patients who were diagnosed as CPT between 2000 and 2020 was obtained from the surveillance, epidemiology, and end results database. Descriptive analysis was used to assess the distribution and tumor-related characteristics of the patients with CPT. Independent prognostic factors for patients with CPT were identified by univariate and multivariate Cox regression analysis. The nomogram was established and evaluated by receiver operating characteristic curve, and decision curve analysis (DCA), calibration curves. The independent prognostic factors for patients with CPT are age, tumor size, surgery, chemotherapy, tumor number, pathologies, and race. For the prognostic nomogram, the area under the curve (AUC) of 60-, 120-, and 180-months were 0.855, 0.869 and 0.857 in the training set and 0.836, 0.864 and 0.922 in the test set. The DCA and calibration curve indicated the good performance of the nomogram. Patients with CPTs can be diagnosed at any age. Among the three histopathological tumors, patients with CPC had the worst prognosis. The nomogram was established to predict the prognosis of patients with CPT, which had satisfactory accuracy, and clinical utility may benefit for clinical decision-making.
Endothelin-1 impairs skeletal muscle myogenesis and development via ETB receptors and p38 MAPK signaling pathway
Authors: Liu Shui-Yu , Chen Luei-Kui , Jhong Yi-Ting , Chen Chien-Wei , Hsiao Li-En , Ku Huei-Chi , Lee Pin-Hsuan , Hwang Guey-Shyang , Juan Chi-Chang 
Published: May 2024

Abstract
Myopenia is a condition marked by progressive decline of muscle mass and strength and is associated with aging or obesity. It poses the risk of falling, with potential bone fractures, thereby also increasing the burden on family and society. Skeletal muscle wasting is characterized by a reduced number of myoblasts, impaired muscle regeneration and increased muscle atrophy markers (Atrogin-1, MuRF-1). Endothelin-1 (ET-1) is a potent vasoconstrictor peptide. Increased circulating levels of ET-1 is noted with aging and is associated with muscular fibrosis and decline of strength. However, the regulatory mechanism controlling its effect on myogenesis and atrophy remains unknown. In the present study, the effects of ET-1 on myoblast proliferation, differentiation and development were investigated in C2C12 cells and in ET-1-infused mice. The results show that ET-1, acting via ETB receptors, reduced insulin-stimulated cell proliferation, and also reduced MyoD, MyoG and MyHC expression in the differentiation processes of C2C12 myoblasts. ET-1 inhibited myoblast differentiation through ETB receptors and the p38 mitogen-activated protein kinase (MAPK)-dependent pathway. Additionally, ET-1 decreased MyHC expression in differentiated myotubes. Inhibition of proteasome activity by MG132 ameliorated the ET-1-stimulated protein degradation in differentiated C2C12 myotubes. Furthermore, chronic ET-1 infusion caused skeletal muscle atrophy and impaired exercise performance in mice. In conclusion, ET-1 inhibits insulin-induced cell proliferation, impairs myogenesis and induces muscle atrophy via ETB receptors and the p38 MAPK-dependent pathway.
Experimental feasibility analysis of quantum/classical coexistence over fibre and free space links
Authors: Stathis Aristeidis , Ntanos Argiris , Toumasis Panagiotis , Lyras Nikolaos K. , Giannoulis Giannis , Avramopoulos Hercules 
Published: May 2024

AbstractThe authors present a novel approach to Quantum Key Distribution (QKD) research, emphasising cost‐effectiveness and practicality using a single photon polarisation‐encoded system employing mainly commercial off‐the‐shelf components. This study diverges from previous high‐cost, high‐end setups by exploring the viability of QKD in more accessible and realistic settings. Our approach focuses on practical measurements of the signal‐to‐noise ratio by analysing polarisation‐encoded photonic qubits over various transmission scenarios. The authors introduce a simplified evaluation method that incorporates experimental measurements, such as noise sources and losses, into a semi‐empirical theoretical framework. This framework simulates the standard DS‐BB84 protocol to estimate Secure Key Rates (SKRs), offering an alternative approach on the evaluation of the practical implementation of QKD. Specifically, the authors examine the feasibility of QKD over a 2.2 km intra‐campus fibre link in coexistence scenarios, identifying optimal Wavelength‐Division Multiplexing allocations to minimise Raman noise, achieving an expected SKR of up to 300 bps. Additionally, the authors’ study extends to 40 m indoor and 100 m outdoor Free‐Space Optical (FSO) links using low‐cost components, where the authors recorded Quantum Bit Error Rate (QBER) values below 3.2%, allowing for possible SKRs up to 600 bps even in daylight operation. The converged fibre/FSO scenario demonstrated robust performance, with QBER values below 3.7% and an expected SKR of over 200 bps. Our research bridges the gap between high‐end and economical QKD solutions, providing valuable insights into the feasibility of QKD in everyday scenarios, especially within metropolitan fibre based and FSO links. By leveraging cost‐effective components and a simplified single photon exchange setup, the authors work paves the way for the effortless characterisation of deployed infrastructure, highlighting its potential in diverse settings and its accessibility for widespread implementation.
Gait‐based human recognition based on millimetre wave multiple input multiple output radar point cloud constructed using velocity‐depth‐time
Authors: He Xianxian , Zhang Yunhua , Dong Xiao 
Published: May 2024

AbstractGait recognition is to recognise different individuals based on their faint differences of gait characteristics, which is different from and more challengeable than the recognition of human activities based on relatively bigger differences between different motions. Existing millimetre‐wave Multiple Input Multiple Output radar point cloud data contains time‐varying three‐dimensional spatial positions, velocity, and intensity information. How to enhance the accuracy of gait recognition by effectively utilising the available radar point cloud data has become an attractive research topic in recent years. A velocity‐depth‐time (VDT) based point cloud construction method for millimetre‐wave Multiple Input Multiple Output radar is proposed for gait recognition application, which can not only alleviate the sparsity problem of mmWave point cloud but also make the constructed point cloud to exhibit temporal structural features of micro‐motions, and therefore enable the successful application of PointNet++ to mmWave‐MIMO point cloud gait recognition. New point clouds are constructed by the proposed method using public gait recognition datasets of 10 and 20 individuals from mmWave‐MIMO radar, which are used to conduct gait recognition experiments using PointNet++. The results show that the point clouds constructed based on VDT are more conducive to the gait recognition task. Even using the classic PointNet++ model, which is not specially designed for radar point clouds, high recognition accuracy can be achieved for gait recognition tasks. The recognition accuracies are improved by 11% and 12% in this work for datasets of 10 and 20 individuals, respectively, compared with the 84% and 80% achieved by the traditional method using the same dataset and the same PointNet++ model, while the accuracies are improved by 5% and 12%, respectively, compared with the 90% and 80% achieved by the original dataset thesis method corresponding to 10‐individual and 20‐individual datasets.