bluuebunny/crossref_metadata_2025_split huggingface dataset:
PHARMACOKINETIC DRUG-DRUG INTERACTIONS MEDIATED BY ORGANIC CATION TRANSPORTERS: ARE ANTIMALARIAL DRUGS SIGNIFICANTLY AFFECTED?
Authors: ONYEJI Cyprian Ogbonna 
Published: May 2024

A clear understanding of all the processes that influence drug disposition is important to enable a prediction of pharmacokinetic drug interactions. Xenobiotics are transported across bio-membranes and the process is mediated by various membrane transporters which include “Organic Cation Transporters” (OCTs). OCTs are specifically involved in the transport of several molecules that have positive charges in vivo and these include a wide variety of weakly basic drugs.As several antimalarial drugs are weakly basic and can be cationic in biological fluids, the contribution of OCTs to the drug disposition appears to be underestimated because most studies on the pharmacokinetic drug interaction with antimalarial drugs are focused on the interactions at the sites of drug metabolism. This review provides an update on the significance of OCTs on the pharmacokinetic disposition of antimalarial agents with a view to identifying potentials for drug interactions that could involve concurrently administered drugs which are either inhibitors or substrates of OCTs. A very significant likelihood exists for concurrent use of antimalarial drugs with other medicines because of the occurrence of comorbidities with malaria. There are limited studies on antimalarial pharmacokinetic drug-drug interaction studies in which role of OCTs are investigated. From the literature, and using in vitro studies, the following antimalarial drugs, chloroquine, piperaquine, proguanil, and cycloguanil have been reported to be substrates of different OCTs while tafenoquine, pyrimethamine, trimethoprim, quinine, and mefloquine were shown to be inhibitors. Atovaquone and artesunate were shown not to be substrates and did not demonstrate any inhibitory potency. This information provide basis for prediction of any potential interaction between antimalarial drugs and other co-administered medicines which are inhibitors/substrates of the transporter proteins.

Peer Review History:
Received 6 February 2024; Revised 15 March 2024; Accepted 26 April; Available online 15 May 2024
Academic Editor: Dr. Nuray Arı, Ankara University, Turkiye, ari@ankara.edu.tr
Average Peer review marks at initial stage: 6.5/10
Average Peer review marks at publication stage: 7.5/10
Reviewers:
Dr. George Zhu, Tehran University of Medical Sciences, Tehran, Iran, sansan4240732@163.com
Dr. Bilge Ahsen KARA, Ankara Gazi Mustafa Kemal Hospital, Turkey, ahsndkyc@gmail.com
Studies on the Effect of Water Stress on Root Traits in Redgram Genotypes
Authors: Amarapalli Geetha 
Published: May 2024

The experiment was conducted during July–November, 2019 at Regional Agriculture Research Station, Professor Jayashankar Telangana State Agricultural University, Palem, Nagarkurnool district, Telangana State, India. The main treatments had five red gram genotypes and water stress levels were taken as sub-treatment in 3 replications in factorial RBD using specialized root structure made with cement bricks. There was great variability in the yield performance of different Redgram genotypes under drought conditions. The experiment was conducted to select genotypes with efficient root architecture and associated traits under drought stress. Root studies were performed with the Delta T automatic root scanner. The SPAD chlorophyll meter was used to measure the SCMR value. The present study results revealed that genotype, Maruti showed significant superiority for character plant height and SCMR under non-stress, mild stress and severe stress conditions. The same genotype showed superior values for main root length under control and mild stress. Whereas, Laxmi recorded the highest plant height under severe stress and the same genotype also showed significant superiority for total plant dry weight, root dry weight and root area under severe stress. The genotype Laxmi showed significant character, root area and diameter superiority under mild stress. ICPL-20176 recorded significant superiority for main root length under severe stress and root tip for mild stress. The identified genotypes can be used as the parents in future drought-proof breeding useful for cultivating in water stress conditions.
PERBANDINGAN SUPLEMENTASI JENIS MINERAL ORGANIK DALAM RANSUM TERHADAP JUMLAH ERITROSIT, HEMATOKRIT DAN GLUKOSA DARAH PADA KAMBING RAMBON
Authors: Beninda Adellia , Husni Ali , Fathul Farida , Hartono Madi 
Published: May 2024

Penelitian ini bertujuan untuk mengetahui perbandingan dan perlakuan terbaik mineral Ca dan Mg organik dengan mineral Ca dan Mg sabun dalam ransum terhadap jumlah eritrosit, hematokrit dan glukosa darah pada kambing rambon. Penelitian ini dilaksanakan pada Februari-April 2023 dan berlokasi di Kandang Jurusan Peternakan, Fakultas Pertanian, Universitas Lampung. Percobaan dilakukan pada 12 ekor kambing rambon jantan, dengan Rancangan Acak Kelompok (RAK) yang terdiri dari 3 perlakuan dan 4 ulangan. Perlakuan pada penelitian ini yaitu: P1 : ransum basal (onggok, silase daun singkong, bungkil sawit, dan dedak ), P2 : ransum basal + mineral organik (Ca dan Mg), dan P4 : ransum basal + mineral sabun (Ca dan Mg). Data yang diperoleh dianalisis menggunakan Analisis Sidik Ragam (ANOVA). Peubah yang diamati adalah eritrosit, hematokrit dan glukosa darah. Pemberian rasum dengan mineral organik (Ca dan Mg) dan pemberian mineral sabun (Ca dan Mg) tidak berpengaruh nyata (P<0,05). Berdasarkan penelitian yang telah dilakukan dapat disimpulkan bahwa perlakuan pemberian mineral organik (Ca dan Mg) dengan mineral organik sabun (Ca dan Mg) tidak berpengaruh nyata terhadap jumlah eritrosit, hemtokrit, dan glukosa darah pada kambing Rambon.
PENGARUH PEMBERIAN TONGKOL JAGUNG TERAMONIASI TERHADAP POLA TINGKAH LAKU MAKAN DOMBA EKOR TIPIS
Authors: Kurniantha Muhammad Aldi , Adhianto Kusuma , Husni Ali , Qisthon Arif 
Published: May 2024

Tujuan penelitian ini adalah untuk mengetahui pengaruh untuk mengetahui tingkah laku makan dari domba ekor tipis yang diberi pakan amoniasi tongkol jagung. Penelitian ini dilaksanakan Agustus – Oktober 2022 di kandang Jurusan Peternakan, Fakultas Pertanian, Universitas Lampung. Penelitian ini merupakan penelitian eksperimental dengan menggunakan rancangan acak kelompok (RAK) yang terdiri dari 3 perlakuan dan setiap perlakuan diulang sebanyak 5 kali serta pada setiap satuan percobaan terdapat 1 ekor domba ekor tipis dengan pengelompokkan sesuai bobot badan ternak dengan perlakuan amoniasi tongkol jagung menggunakan urea 5%. Adapun rancangan perlakuan yang digunakan adalah sebagai berikut: P0: complete feed 100 %; P1: 75 % complete feed + 25 % tongkol jagung teramoniasi (5% urea); P2: 50 % complete feed + 50 % tongkol jagung teramoniasi (5% urea). Peubah yang diamati adalah tingkah laku makan domba ekor tipis jantan. Data yang diperoleh ditabulasi dan dianalisis menggunakan analisis of varian (ANOVA) dengan taraf 5% dan dilanjutkan Beda Nyata Terkecil (BNT). Hasil penelitian menunjukkan bahwa perlakuan tidak berpengaruh nyata terhadap lama makan domba dengan nilai rata-rata perlakuan yaitu P0 3,15 jam/hari; P1 3,43 jam/hari; dan P2 3,29 jam/hari. Hasil penelitian menunjukan bahwa perlakuan tidak berpengaruh nyata terhadap frekuensi makan domba dengan nilai rata-rata perlakuan yaitu P0 11,65 kali/hari; P1 12,48 kali/hari; dan P2 10,95. Hasil penelitian menunjukan bahwa perlakuan tidak berpengaruh nyata terhadap lama ruminasi dengan nilai rata-rata pada tiap perlakuan yaitu P0 3,33 jam/hari; P1 3,66 jam/hari; dan P2 3,26 jam/hari.Hasil penelitian menunjukan bahwa perlakuan berpengaruh nyata terhadap frekuensi ruminasi dengan nilai rata-rata perlakuan yaitu P0 10,25 kali/hari; P1 9,36 kali/hari; dan P2 12,83 kali/hari. Dari hasil penelitian disimpulkan bahwa subtitusi tongkol jagung teramoniasi tidak menunjukkan perbedaan kecuali frekuensi ruminasi.
Logística inversa en las microempresas textiles: caso Cantón Otavalo –Ecuador
Authors: Orbes Revelo Belky Nerea , López Espinoza Macarena Aracely 
Published: May 2024

En este artículo se presentan los resultados de la investigación realizada acerca de la aplicación de la logística inversa en el sector textil de la ciudad de Otavalo con el fin de que las microempresas tengan la posibilidad de reciclar los desechos para luego proceder a una nueva elaboración de un nuevo producto. Por tal motivo, es necesario que se desarrolle el proceso de logística inversa y se tomen decisiones que beneficiarán al medio ambiente y a la sociedad otavaleña.
Para el desarrollo de este estudio, inicialmente se realizó un estudio de la literatura que comprendió las definiciones y los tipos de logística inversa, tanto bajo el método cualitativo como el cuantitativo, que permitió estudiar el sector microempresarial textilero por medio de encuestas. Posteriormente, se obtuvieron resultados detallados de productos, materias primas y desechos, con el único propósito de dar el giro que tenían los desechos como destino final el vertedero generando un efecto negativo para el medio ambiente. Con todos los resultados, se propone mejorar los procesos internos y externos de la selección de residuos textiles, con el apoyo de responsabilidad compartida de los stakeholders, como el Gobierno, la Sociedad Civil y las Empresas Públicas, forjando la concientización de la aplicación de la logística inversa en el proceso de planificación, implantación, control y reducción de tiempos mediante el modelo SCOR, buscando la eficiencia y eficacia dentro de las microempresas para obtener al final el retorno de estos residuos para un nuevo producto.
Diagnosis of The Training of Business Administrators of The National School of Sports and Its Incidence on The Generation of Soft Skills Year 2023
Authors: Tenorio Luis Enrique David , Núñez Claudia Lorena Vásquez , Ospina Alexis Rojas 
Published: May 2024

Objective: The research carries out a diagnosis of the training of business administrators and its impact on the generation of soft skills of the students of the program, at the National Sports School University Institution for the year 2023.

Method: A theoretical-empirical investigation was carried out, whose approach is descriptive, keeping in mind the objective to be achieved. Reflecting whether the training activities in which the student is involved really contribute to the development of soft skills. Starting from the idea of ​​the constant change that is evident today in the capture of human capital by organizations, turning the above into a fundamental and necessary point for the evaluation of human capital.

Research Findings and Discussions: The labor field was identified as a generating source of soft skills in the majority of the research participants, being of utmost importance the incursion into the program of activities that generate the previous ones, starting from the confrontation of the academic field with the economic sector, in simulated environments.

Implications of the research: The research involved determining the scope and limitations of business administrator training around soft skills, a fundamental aspect regarding the student's employment relationship.

Value originality: This research helps higher education entities identify adjustments or changes that they must make regarding the training of business administrators in favor of a successful connection to the labor field.
The Relationship Between Financial Analysis and Business Performance at Public Universities in Vietnam
Authors: Huong Hoang Dinh , Thao Vu Thi , Dinh Truong Duc 
Published: May 2024

Purpose: This article aims to clarify the relationship between financial analysis and business performance at public universities in Vietnam. In addition, the influence of financial analysis on operational results.

Theoretical framework: In the context of increasing financial autonomy in public universities in Vietnam, the issue of financial analysis aims to provide information for managers to plan, organize, control, and make decisions. Financial information must be reliable, transparent, and accountably defined. Most universities in Vietnam are not actively engaged in financial analysis activities, and there are significant research gaps globally.

Method/design/approach: The research sample, collected online, consisted of 425 respondents in managerial positions (including accounting, auditing, financial, vice principal, and principal positions) in public universities. Sampling took place over a 3-month period from September 2022 to December 2023. Using quantitative research and the PLS-SEM structural equation modeling in SPSS 20 and AMOS 20 software.
Results and conclusion: The study identified two factors with the strongest influence on financial analysis in public universities in Vietnam: (i) the analysis data base (AD); and (ii) the analysis content (CA) and influence of financial analysis on operational results. The research provided in-depth insights and critical discussions and evaluations in financial analysis at public universities in Vietnam, recommending the adoption of public accounting standards for financial reporting developed by the International Public Sector Accounting Standards Board (IPSASB) or the use of EVA indicators (net operating profit after tax minus cost of capital) in financial analysis activities.
Research implications: This research uses the contents of financial analysis and operational results based on prior studies in the realm of the public and universities. Within the context of the digital transformation of the entire society and improving the quality of education, these variables are useful solutions for universities.

Originality/value: This study uses a new research methodology to analyze and measure the relationship between financial analysis and business performance at public universities in Vietnam. The paper's primary contribution is findings that benefit the public universities in Vietnam in the improvement of their training quality and business performance.
Improving the Organizational Efficiency of Manufacturing Enterprises: The Role of Digital Transformation, Resource Planning (ERP), and Business Practices
Authors: Feng Cen , Ali Dhakir Abbas 
Published: May 2024

Purpose: An ERP system's primary goal is to improve an organization's organizational efficiency by controlling and optimizing the use of its resources.

Method: Both quantitative and qualitative data are combined in the mixed-methods methodology to provide a comprehensive understanding of the subject. To assess the degree of ERP deployment and digital transformation, quantitative data will be gathered. On the other hand, the subtleties of business operations and the interactions between these variables will be investigated using qualitative data.

Result and Conclusion: This study offers a thorough grasp of how ERP systems, business processes, and digital transformation can improve organizational effectiveness in manufacturing companies. It advances the field by emphasizing the value of integration and providing useful takeaways as well as recommendations for further study in the quest of manufacturing's operational excellence.

Implication of Research: Examine the issues surrounding data privacy and cybersecurity as well as potential solutions in the context of digital transformation and ERP system integration.

Originality/Value: Examine how industrial companies are now adopting digital transformation. Evaluate ERP systems' contribution to manufacturing operations optimization. Examine how different business practices affect the effectiveness of an organization.
الآثار السلبية للإعلام المرئي على الجانب العقلي و النفسي عند المراهقين من منظور اسلامي.
Authors: حامد زیرەك مغدید , رسول باجلاني جمال فقي 
Published: May 2024

يسَلَّط الضوء في هذا البحث على المراهق (من الجانب العَقليّ والنَّفسي ) في القرآن الكريم من حيث المفهوم و الصيغة والمقصود والمكانة, وفي علم النَّفس الحَديث، وكيفيَّة نموّ هذين الجانبَين في هذه المَرحلة من العمر، وأيضا أهمّية العقل والنفس في القرآن العظيم ومقاصد الشريعة، ويَستقصي البَحث أنواعَ برامج الإعلامية المخططة الإلحادية والفاسدة ..., وشرح طريقهم لنشر الافكار سريا وعلنيا ؛وآثار السلبية للبرامج الفاسدة على الجانبيّ العقلي والنفسي في المراهقين بأسلوب مفصل .
ثمَّ بيّنت فيه بشَكل مفصَّل مؤَامَرات دوليَّة نفَّاثة، وسموم عالَميّة ناجعة، ومكايد عظيمة ـ عدَدا ونَوعا وقوّة ـ تدار علَنا وسرّا لإفساد المراهقين من خلال الإعلام بأنواعه العَديدة، وكيفَ أنَّ الإعلامَ يحاول تزيينَ القَبيح وإفسادَ الفطرة ويمارس الدَّجلَ والسَّخافةَ بالامتياز تحت مسَمَّيات بَرَّاقة جذَّابة، كلّ ذلك لتمرير هذه المؤامَرات خلفَ ستر جميلة.
ثمَّ يبحَث في الإدمان ومفهومه و أنواعه وأسبابه وخاطره على الحالة العَقلية والنَّفسية لدى المراهقين من كلا الجنسَين، وكيفَ تَعمل البرامج الإعلامية وتخطّط لإدمان هذه الفئة العمرية بأفتك أنواع الإدمان وأخطاره، ألا وهو (الإدمان على الإعلام)، وهو إدمان قرننا هذا، ويكثَّف القَول في تأثير الإعلام علی إبعاد الشباب والمراهقين من المشروعات التربويَّة والتنمويَّة والعقلية التي ترشدهم إلى صلاح العقل وحَصافتـه، و الى الصحة النفسيَّة واستقرارها, وتركيز في هذا البحث على الإدمان بالإباحية كالظاهرة المدمرة خاصة بين المراهقة .
وكيفَ أنَّ الإعلامَ صارَ منصَّة للأغبياء والسّفهاء التافهينَ اذين لا بضاعةَ لهم ولا ثقل، بل صار الإعلام حبالةَ صيد للجماعات الإرهابية وعصابات المافيا لغرس الأفكار المتطرفين بين الناس وخاصة بين المراهقين.تجد كلَّ ذلك مفصَّلا في طَيَّات البحث وفصوله.
Study of antimicrobial activity of aqueous and alcoholic Eugenia caryophillata extracts on E.coli bacteria isolated from Diarrhea in children under 5 years in Tikrit city
Authors: Jameel Ala'a Abdul Jabbar , Alanee Ahmed Hashim 
Published: May 2024

Background: Diarrheal disease is common among children worldwide, especially in developing countries.
Aims of study: To Test the inhibitory effectiveness of aqueous and alcoholic Eugenia caryophllata extracts on E.coli which were isolated from young children under five years with diarrhea.
Materials & Methods: One hundred samples were collected from children with diarrhea under five years. 75 isolates of E.coli were isolated and diagnosed based on their phenotypic properities and biochemical tests.
Results and Discussio: The results of the susceptibility test to 13 types of antibiotics using the disc diffusion method showed a variation in the level of resistance to the different antibiotics, and it was found that the most effective antibiotics were Imipenem and Nitrofurantoin. The study used aqueous and alcoholic extracts of Eugenia caryophllata seeds and was tested for their ability to inhibit the growth of E. coli
Evaluation The Efficacy of Barlow and Ortalani Test in The Diagnosis of Developmental Dysplasia of The Hip in Infant in Salah Al-deen General Hospital
Authors: Ahmed Qabas Adil , Alanee Ahmed Hashim 
Published: May 2024

This cross sectional study aimed to assess the effectiveness of clinical examination using the Barlow and Ortolani tests compared to ultrasound diagnosis for identifying developmental dysplasia of the hip (DDH) in infants. The study involved 100 babies aged 1 week to 12 weeks, randomly selected from Salah Al-deen General Hospital between January and June 2020. The infants were examined using the Barlow and Ortolani tests, followed by ultrasound confirmation of DDH diagnosis.
Results showed that 9% of the infants had DDH. Infants with abnormal ultrasound findings had a higher birth weight, and significant associations were found with breech presentation, vaginal bleeding during pregnancy, and a family history of the same condition. Senior specialists were more accurate in diagnosing DDH compared to residents.
The sensitivity of the Barlow and Ortolani maneuvers was low for both residents and seniors, while specificities were high. Positive predictive values were better for residents, but negative predictive values were better for seniors. False-negative rates were lower for seniors, and false-positive rates were generally low.
In conclusion, clinical examination alone may not always accurately identify DDH in infants, as some babies with normal hips may show abnormalities on ultrasound. Conversely, ultrasound scans may indicate clinical dysfunction in babies with normal hips. Female infants had a higher incidence of DDH, and certain risk factors were associated with the condition. The sensitivity of the Barlow and Ortolani tests was limited, but specificities were high, and the choice of examiner impacted predictive values
Physics-Informed Machine Learning Using Low-Fidelity Flowfields for Inverse Airfoil Shape Design
Authors: Wong Benjamin Y. J. , Damodaran Murali , Khoo Boo Cheong 
Published: May 2024

Physics-informed neural networks (PINNs) are a class of scientific machine learning that utilizes differential equations in loss formulations to model physical quantities. Despite recent developments, complex phenomena such as high-Reynolds-number (high-[Formula: see text]) flow remain a modeling challenge without the use of high-fidelity inputs. In this study, a low-fidelity-influenced physics-informed neural network (LF-PINN) is proposed as a surrogate aerodynamic analysis model for inverse airfoil shape design at [Formula: see text]. The LF-PINN is developed in a hybrid approach using low-fidelity flowfields approximated from a viscous-inviscid coupled airfoil analysis tool (mfoil) and physics residuals from the steady, incompressible, two-dimensional Navier–Stokes (NS) equations. The approach is designed to alleviate offline computational costs by avoiding high-fidelity simulations and sustain predicting accuracy using corrections by the physics residuals. The LF-PINN is able to correct the low-fidelity flowfield quantities toward the ground truth, with a mean improvement of about 19% in pressure and about 5% in total velocity based on Euclidean distance comparisons. Evaluation of the airfoil surface pressure coefficient [Formula: see text] distributions shows corrections by the LF-PINN at the suction peak, which largely contributes to lifting forces. Inverse airfoil shape design is conducted using target [Formula: see text] distributions in the objective function, whereby the LF-PINN can approach the expected target shapes while reducing online computational time by at least an order of magnitude compared to direct airfoil analysis tools.
Endolymphatic sac tumor: An urgent case presenting acute intracranial hypertension successfully treated with suboccipital decompressive craniectomy – 8 years of follow-up
Authors: Torres João Antonio Gonçalves Bastos , Ferreira-Pinto Pedro Henrique Costa , Ferreira Domênica Baroni Coelho de Oliveira , Simões Elington Lannes , de Carvalho Felipe Gonçalves , Brito Ana Carolina Gonçalves , Filho José Alberto Almeida , de Sousa Bruna Cavalcante , de Castro Maria Eduarda Viveiros , de Gouvea Pedro Luiz Ribeiro Carvalho , da Silva Wellerson Novaes , Correa Eduardo Mendes , Cruz Thainá Zanon , Nigri Flavio 
Published: May 2024

Background:
Endolymphatic sac tumor (ELST) is a rare lesion. It may be sporadically or associated with Von Hippel-Lindau syndrome. Progressive audiovestibular symptoms characterize the typical clinical presentation. Here, we report a unique case of ELST with acute intracranial hypertension (IH) due to tumor compression, successfully treated with an urgent suboccipital decompressive craniectomy (SDC).

Case Description:
A 33-year-old woman previously underwent a biopsy and ventriculoperitoneal shunt. The histopathological finding revealed an ELST. One year later, she developed headache, vomiting, and somnolence due to brainstem compression. An urgent SDC was performed. One month later, preoperative endovascular embolization and partial tumor resection were carried out. After 6 months adjuvant radiotherapy (RT) therapy was administered. She has been under follow-up for 8 years since the last surgical procedure, and the tumor remains stable.

Conclusion:
ELST generally has a progressive clinical course. This is a unique case with acute IH due to tumor compression. The tumor’s high vascularity and the unavailability of endovascular embolization precluded its resection. SDC was an alternative approach. The final treatment included tumor embolization, surgical resection, and RT. No progression was observed for 8 years after the last procedure, and long-term follow-up is warranted.