bluuebunny/crossref_metadata_2025_split huggingface dataset:
Structure of plasmonic multi spectral Apta sensor and analyzing of bulk and surface sensitivity
Authors: Parviz Mahya , Shokorlou Younes Majd , Heidarzadeh Hamid 
Published: June 2024

AbstractIn this work, a multispectral aptasensor structure, including a sub-layer and two side walls, was presented. The cells are positioned at the down and top of the structure, with the down cells oriented perpendicular to the walls and the top cells aligned parallel to the walls. The validity of the findings was verified by the utilization of a numerical simulation technique known as 3D Finite Difference Time Domain (FDTD). The biosensor under consideration exhibits sensitivities of 1093.7 nm/RIU, 754 nm/RIU, and 707.43 nm/RIU in mode III, mode II, and mode I, respectively. In the majority of instances, the quantity of analyte available is insufficient to coat the surface of the sensor thoroughly. Consequently, in this study, the evaluation of surface sensitivity was undertaken alongside bulk sensitivity. The surface sensitivity of the suggested structure for mode II in the sensor layer, with thicknesses of 10, 20, 30, and 70 nm, is measured to be 25, 78, 344, and 717.636 nm/RIU, respectively. Our design incorporates a unique arrangement of sub-layer and side walls, with cells positioned to maximize interaction with the target analyte. This innovative configuration, combined with Ag for its superior plasmonic properties, enables the detection of E. coli O157 with remarkable sensitivity.
Collaborative governance and personal relationships for sustainability transformation in the textile sector
Authors: Beyers Felix 
Published: June 2024

AbstractThis paper explores the potential for collaborative governance in the textile sector to act as a catalyst for sustainability transformation. The article originated from a 4-year research project examining a multi-stakeholder initiative (MSI), the German Partnership for Sustainable Textiles. It sheds light on the complex but interdependent connections between collaborative governance and personal relationships. While emphasising the role played by MSIs in creating important space for negotiating interests, it points towards the co-benefits of building relationships beyond stakeholder boundaries. Obstacles such as governance structures and the fragmentation of the governance landscape hinder opportunities for personal, political, and practical transformation. While highlighting the importance of private governance, it also stresses the role of state regulation in global economies, e.g. in the current debate on the EU Due Diligence Act. Finally, suggestions are made for designing governance spaces that support the development of social relationships while promoting transformation by ensuring the equal participation of stakeholders, employing learning and facilitation experts, and promoting joint decision-making processes.
ASS1 metabolically contributes to the nuclear and cytosolic p53-mediated DNA damage response
Authors: Lim Lisha Qiu Jin , Adler Lital , Hajaj Emma , Soria Leandro R. , Perry Rotem Ben-Tov , Darzi Naama , Brody Ruchama , Furth Noa , Lichtenstein Michal , Bab-Dinitz Elizabeta , Porat Ziv , Melman Tevie , Brandis Alexander , Malitsky Sergey , Itkin Maxim , Aylon Yael , Ben-Dor Shifra , Orr Irit , Pri-Or Amir , Seger Rony , Shaul Yoav , Ruppin Eytan , Oren Moshe , Perez Minervo , Meier Jordan , Brunetti-Pierri Nicola , Shema Efrat , Ulitsky Igor , Erez Ayelet 
Published: June 2024

AbstractDownregulation of the urea cycle enzyme argininosuccinate synthase (ASS1) in multiple tumors is associated with a poor prognosis partly because of the metabolic diversion of cytosolic aspartate for pyrimidine synthesis, supporting proliferation and mutagenesis owing to nucleotide imbalance. Here, we find that prolonged loss of ASS1 promotes DNA damage in colon cancer cells and fibroblasts from subjects with citrullinemia type I. Following acute induction of DNA damage with doxorubicin, ASS1 expression is elevated in the cytosol and the nucleus with at least a partial dependency on p53; ASS1 metabolically restrains cell cycle progression in the cytosol by restricting nucleotide synthesis. In the nucleus, ASS1 and ASL generate fumarate for the succination of SMARCC1, destabilizing the chromatin-remodeling complex SMARCC1–SNF5 to decrease gene transcription, specifically in a subset of the p53-regulated cell cycle genes. Thus, following DNA damage, ASS1 is part of the p53 network that pauses cell cycle progression, enabling genome maintenance and survival. Loss of ASS1 contributes to DNA damage and promotes cell cycle progression, likely contributing to cancer mutagenesis and, hence, adaptability potential.
MCM8 interacts with DDX5 to promote R-loop resolution
Authors: Wen Canxin , Cao Lili , Wang Shuhan , Xu Weiwei , Yu Yongze , Zhao Simin , Yang Fan , Chen Zi-Jiang , Zhao Shidou , Yang Yajuan , Qin Yingying 
Published: June 2024

AbstractMCM8 has emerged as a core gene in reproductive aging and is crucial for meiotic homologous recombination repair. It also safeguards genome stability by coordinating the replication stress response during mitosis, but its function in mitotic germ cells remains elusive. Here we found that disabling MCM8 in mice resulted in proliferation defects of primordial germ cells (PGCs) and ultimately impaired fertility. We further demonstrated that MCM8 interacted with two known helicases DDX5 and DHX9, and loss of MCM8 led to R-loop accumulation by reducing the retention of these helicases at R-loops, thus inducing genome instability. Cells expressing premature ovarian insufficiency-causative mutants of MCM8 with decreased interaction with DDX5 displayed increased R-loop levels. These results show MCM8 interacts with R-loop-resolving factors to prevent R-loop-induced DNA damage, which may contribute to the maintenance of genome integrity of PGCs and reproductive reserve establishment. Our findings thus reveal an essential role for MCM8 in PGC development and improve our understanding of reproductive aging caused by genome instability in mitotic germ cells.
K128 ubiquitination constrains RAS activity by expanding its binding interface with GAP proteins
Authors: Magits Wout , Steklov Mikhail , Jang Hyunbum , Sewduth Raj N , Florentin Amir , Lechat Benoit , Sheryazdanova Aidana , Zhang Mingzhen , Simicek Michal , Prag Gali , Nussinov Ruth , Sablina Anna 
Published: June 2024

AbstractThe RAS pathway is among the most frequently activated signaling nodes in cancer. However, the mechanisms that alter RAS activity in human pathologies are not entirely understood. The most prevalent post-translational modification within the GTPase core domain of NRAS and KRAS is ubiquitination at lysine 128 (K128), which is significantly decreased in cancer samples compared to normal tissue. Here, we found that K128 ubiquitination creates an additional binding interface for RAS GTPase-activating proteins (GAPs), NF1 and RASA1, thus increasing RAS binding to GAP proteins and promoting GAP-mediated GTP hydrolysis. Stimulation of cultured cancer cells with growth factors or cytokines transiently induces K128 ubiquitination and restricts the extent of wild-type RAS activation in a GAP-dependent manner. In KRAS mutant cells, K128 ubiquitination limits tumor growth by restricting RAL/ TBK1 signaling and negatively regulating the autocrine circuit induced by mutant KRAS. Reduction of K128 ubiquitination activates both wild-type and mutant RAS signaling and elicits a senescence-associated secretory phenotype, promoting RAS-driven pancreatic tumorigenesis.
Load torque composite synchronous control of dual‐driven systems
Authors: Xie Bin , Yao Yuan , Lei Li , Wang Zaixiang , Li Yesong 
Published: June 2024

AbstractFor enhancing the load torque synchronization performance of dual‐driven systems, the inherent coupling effect between the parallel axes is analyzed first and could be described as two distinct components of the synchronous error. Thus, the feedforward‐feedback composite synchronous control scheme is proposed in this paper to eliminate these desynchronization factors. Secondly, the selection of synchronization objectives such as speeds, positions or currents of parallel axes is analyzed, which may not accurately reflect the actual load desynchronization due to mismatch dynamics. To overcome this drawback, the synchronous feedback controller is modified by incorporating a load torque observer, which can provide good adaptation to modelling errors, disturbances and eliminate the load desynchronization effectively. Simulation and experimental results demonstrate significant improvement in load torque synchronization performance achieved by the proposed control scheme.
Depression detection with machine learning of structural and non‐structural dual languages
Authors: Rehmani Filza , Shaheen Qaisar , Anwar Muhammad , Faheem Muhammad , Bhatti Shahzad Sarwar 
Published: June 2024

AbstractDepression is a serious mental state that negatively impacts thoughts, feelings, and actions. Social media use is rapidly growing, with people expressing themselves in their regional languages. In Pakistan and India, many people use Roman Urdu on social media. This makes Roman Urdu important for predicting depression in these regions. However, previous studies show no significant contribution in predicting depression through Roman Urdu or in combination with structured languages like English. The study aims to create a Roman Urdu dataset to predict depression risk in dual languages [Roman Urdu (non‐structural language) + English (structural language)]. Two datasets were used: Roman Urdu data manually converted from English on Facebook, and English comments from Kaggle. These datasets were merged for the research experiments. Machine learning models, including Support Vector Machine (SVM), Support Vector Machine Radial Basis Function (SVM‐RBF), Random Forest (RF), and Bidirectional Encoder Representations from Transformers (BERT), were tested. Depression risk was classified into not depressed, moderate, and severe. Experimental studies show that the SVM achieved the best result with anaccuracy of 0.84% compared to existing models. The presented study refines thearea of depression to predict the depression in Asian countries.
Robust adaptive non‐linear alignment algorithm for SINS/DVL integrated navigation system based on variational Bayesian
Authors: Zhu Bing , Li Jingshu , Cui Guoheng , Li Zuohu , Tian Ge , Guo Xia 
Published: June 2024

AbstractThe problem of dynamic attitude alignment for strapdown inertial navigation system (SINS) and Doppler velocity log (DVL) integrated navigation has become a research hotspot. Underwater complex environment makes DVL output vulnerable to non‐Gaussian noise pollution, which makes it difficult to converge the SINS misalignment angle to within 1° based on analytical coarse alignment. This is to say, the performance of SINS fine alignment via Kalman filter will be degraded because the model of initial alignment exhibits non‐linearity. The inaccurate and/or unknown prior information of measurement noise statistical characteristics will also degrade the filtering performance. To ensure the SINS/DVL alignment accuracy under non‐linear, non‐Gaussian and uncertain conditions, this paper proposed a robust adaptive unscented Kalman filter (UKF) based on Variational Bayesian (VB) method (VBRAUKF). The proposed VBRAUKF improves the adaptability and robustness of UKF from the following two main aspects. Firstly, an adaptive estimation strategy for the measurement noise covariance is designed based on the VB algorithm, which can restrain the effect of inaccurate observation model and improve the adaptive ability of the filtering method. Secondly, an expansion factor is designed based on Mahalanobis distance algorithm, which can restrain the effect of non‐Gaussian noise and improve the robustness of the filtering method. The experimental results for the problem of the SINS/DVL dynamic alignment under mixed Gaussian noise and/or outlier conditions demonstrate the superiority of the proposed VBRAUKF over the traditional ones.
Apparent non-variable stars from the Kepler mission
Authors: Paunzen E. , Binder F. , Cyniburk A. , Duffek M. N. , Haberhauer F. , Heinreichsberger C. , Kohlhofer H. , Kueß L. , Maitzen H. M. , Saalmann T. , Schanz A. M. , Schauer S. , Schmidt K. , Tokareva A. , Wizani I. 
Published: June 2024

Context. The analysis of non-variable stars is generally neglected in the literature. However, such objects are needed for many calibration processes and for testing pulsational models. The photometric time series of the Kepler satellite mission still stand as the most accurate data available today and are excellently suited to the search for non-variable stars.
Aims. We analysed all long-cadence light curves for stars not reported as a variable so far from the Kepler satellite mission. Using the known characteristics and flaws of these data sets, we defined three different frequency ranges where we searched for non-variability.
Methods. We used the Lomb–Scargle periodogram and the false-alarm probability (FAP) to analyse the cleaned data sets of 138 451 light curves. We then used log FAP ≥ −2 to define a star as ‘non-variable’ in the ranges below 0.1 c/d, 0.1 to 2.0 c/d, and 2.0 to 25.0 c/d, respectively. Furthermore, we also calculated the standard deviation of the mean light curve to obtain another parameter.
Results. In total, we found 14 154 stars that fulfil the set criteria. These objects are mostly cooler than the 7000 K populating the whole main sequence (MS) to the red giant branch (RGB).
New ACV variables discovered in the Zwicky Transient Facility survey
Authors: Bauer-Fasching B. , Bernhard K. , Brändli E. , Burger H. , Eisele B. , Hümmerich S. , Neuhold J. , Paunzen E. , Piecka M. , Ratzenböck S. , Prišegen M. 
Published: June 2024

Context. The manifestation of surface spots on magnetic chemically peculiar (mCP) stars is most commonly explained by the atomic diffusion theory, which requires a calm stellar atmosphere and only moderate rotation. While very successful and well described, this theory still needs to be revised and fine-tuned to the observations.
Aims. Our study aims to enlarge the sample of known photometrically variable mCP stars (ACV variables) to pave the way for more robust and significant statistical studies. We derive accurate physical parameters for these objects and discuss our results in the framework of the atomic diffusion theory.
Methods. We studied 1314 candidate ACV variables that were selected from the Zwicky Transient Factory catalogue of periodic variables based on light curve characteristics. We investigated these objects using photometric criteria, a colour-magnitude diagram, and spectroscopic data from the LAMOST and Gaia missions to confirm their status as ACV variables.
Results. We present a sample of 1232 new ACV variables, including information on distance from the Sun, mass, fractional age on the main sequence, fraction of the radius between the zero-age and terminal-age main sequence, and the equatorial velocity and its ratio to the critical velocity.
Conclusions. Our results confirm that the employed selection process is highly efficient for detecting ACV variables. We have identified 38 stars with vequ in excess of 150 km s−1 (with extreme values up to 260 km s−1). This challenges current theories that cannot explain the occurrence of such fast-rotating mCP stars.
Dating the late Miocene marine sediments around the southern middle Durance valley (Provence, SE France): new evidences for a Tortonian age
Authors: Demory François , Delanghe Doriane , Braucher Régis , Blard Pierre-Henri , Nutz Alexis , Conesa Gilles , Ségué-Passama Gaëlle , Hollender Fabrice , Duvail Cédric , Fioravanti Anna , Léanni Laetitia ,   Aster Team, Bellier Olivier 
Published: June 2024

The present study aims dating the topmost 50 m of a 115 m-long core retrieved from a valley located in the Cadarache Area (Upper Provence, South East France). Based on burial dating by in situ produced cosmogenic nuclides (10Be, 26Al and 21Ne), and paleomagnetic analyses, a Tortonian age was determined for the sedimentary succession exhibited in the core. In addition, thin sections, grain size analyses and quartz morphoscopy were used to characterize a shallow marine environment and to correlate the sediment core to the surrounding exposed sections. When comparing the studied sedimentary record to global sea level estimates, we establish that the local Tortonian transgression was not synchronous with the global scale sea level high-stand, but happened more likely later, during a global regressive trend. The timing of the Tortonian flooding in Upper Provence was therefore most probably driven by regional tectonic forcing.
Finally, the Tortonian shallow marine sediments are topped by lacustrine tight carbonates. These carbonates protect the marine sediments from the following major erosional events resulting from the Messinian sea level drop and from interglacial-glacial fluctuations that both yielded to the present-day valley topography.
Satellitengestützte Gewinnung pflanzlicher Rohstoffe für die
Herstellung hochwertiger pharmazeutischer Produkte
Authors: Lorenz Matthias 
Published: June 2024

AbstractFor the worldwide sourcing of medicinal plants as a high-quality raw material for
pharmaceutical processing, the use of satellite data and drones is of great
importance for quality assurance, risk assessment and risk mitigation, for
finding new raw material occurrences, research and development and as part of
GACP-compliant documentation and audits.In many cases, recording the exact location data using GPS provides the basis for
subsequent evaluations and assessments of risks to the product and the
environment. In audits, they provide exact and quickly available documentation
of the production site or region for wild collection, the location of primary
processing and the transportation routes of the sensitive fresh matter for
subsequent drying.Screenings are also based on this method and allow geographical “mapping” in
order to identify certain characteristics of populations or individual plants,
e. g., as eco- or chemotypes. These can be propagated and cultivated as “elite
crops” for specific requirements.Remote sensing satellite images visualize structures, colours and plant species
in natural habitats and enable the identification of medicinal plant occurrences
in unknown areas. Recognition requires training with data that must be obtained
on site.
Phytotherapie bei akuten Atemwegsinfekten – ein
Überblick
Authors: Koch Anna K. , Langhorst Jost 
Published: June 2024

ZusammenfassungEinige medizinische AWMF-Leitlinien empfehlen die Integration von Phytotherapie
in der Behandlung von Atemwegserkrankungen. Auch die European Medicines Agency
(EMA) spricht sich positiv zur Anwendung bestimmter Phytotherapeutika bei
Atemwegsinfekten aus. Die Empfehlungen der EMA begründen sich zumeist auf
traditionellem (traditional) oder etabliertem (well-established) Gebrauch.
Teilweise liegt auch durch Metaanalysen Evidenz für die Wirksamkeit bestimmter
Phytotherapeutika bspw. bei Erkältungen und Husten, sowohl bei Kindern als auch
bei Erwachsenen vor. Die vorhandenen Studien sind aber oftmals von geringer
Qualität. Weitere hochwertige Studien sind erforderlich, um diese Erkenntnisse
zu stärken und das volle Potenzial der Phytotherapie in Therapie und Prävention
zu realisieren.
Frühe allergische Sensibilisierung – frühe Allergen-Immuntherapie?
Authors: Vogelberg Christian 
Published: June 2024

ZUSAMMENFASSUNGAllergische Sensibilisierungen gegen Atemwegsallergene treten häufig bereits im jungen Kleinkindalter auf und bleiben im Verlauf meist bestehen. Damit verbunden ist ein erhöhtes Risiko für die Manifestation eines Asthma bronchiale. Die Allergen-Immuntherapie ist die einzige kausale Therapieform bei Allergien. Für die Anwendung im Kleinkindalter existieren bislang nur wenige Studien, die darauf hinweisen, dass sowohl die sublinguale als auch die subkutane Allergen-Immuntherapie eine sichere Behandlungsform darstellen und Kleinkinder möglicherweise besser auf eine Allergen-Immuntherapie reagieren als andere. Weitere Studien zur Sicherheit, Wirksamkeit, zum präventiven Effekt und zur Toleranz sowie Adhärenz der Allergen-Immuntherapie im Kleinkindalter sind notwendig.
Anstieg invasiver Erkrankungen durch Streptokokken und komplizierte Pneumonien zum Ende der COVID-19-Pandemie
Authors: Ankermann Tobias , Liese Johannes G. 
Published: June 2024

ZUSAMMENFASSUNGIm Winter 2022/2023 kam es in Deutschland bei Kindern zu einer Zunahme von invasiven schweren bakteriellen Infektionserkrankungen und komplizierten Pneumonien mit Nachweis von S. pyogenes und S. pneumoniae. Dies ging nach Lockerung der Pandemie-bezogenen nicht-pharmakologischen Interventionen mit einem Wiederauftreten von Viren, wie RSV, Influenza und humanen Metapneumovirus, einher, die während der COVID-19-Pandemie kaum nachweisbar waren.
Smart-Technologies in der Kinderpneumologie und -allergologie
Authors: Knopek Antonia , Lex Christiane 
Published: June 2024

ZUSAMMENFASSUNGIn der Medizin werden immer mehr digitale Anwendungen genutzt. Insbesondere der internationale Markt für medizinische Smart-Technologies wächst stetig und umfasst vielfältige Angebote, die von Apps bis zu mobilen Messgeräten reichen – sucht man jedoch deutschsprachige, für Kinder und Jugendliche geeignete Angebote, so ist die Auswahl deutlich geringer. Für die pädiatrische Pneumologie zeigen Studien erste vielversprechende Ergebnisse für den Einsatz von elektronischen Symptomtagebüchern, Smartphone-Spirometern und digitalen Inhalationshilfen. Digitale Hilfsmittel erhöhen die Therapieadhärenz bei Kindern mit Asthma. Im Bereich der pädiatrischen Allergologie sind vor allem Apps zur Pollenflugvorhersage weit verbreitet. Die Anwendung von Smart-Technologies könnte den Therapieerfolg bei verschiedenen Erkrankungen verbessern und die Versorgung in der pädiatrischen Pneumologie und Allergologie erleichtern. Aktuell steckt die Anwendung digitaler Anwendungen in diesem Bereich jedoch noch in ihren Anfängen, weshalb eine differenzierte Auswahl geeigneter Apps und Geräte nötig ist.
Nahrungsmittelprotein-induziertes Enterokolitis-Syndrom
Authors: Finger Antje 
Published: June 2024

ZUSAMMENFASSUNGDas Nahrungsmittelprotein-induzierte Enterokolitis-Syndrom (engl.: Food protein-induced enterocolitis syndrome, im Folgenden als FPIES bezeichnet) ist eine nicht-IgE-vermittelte Nahrungsmittelallergie und präsentiert sich in 2 Formen. In einer akuten Form, die vom Säuglings- bis ins Erwachsenenalter vorkommt und einer chronischen Form, die man ausschließlich bei Säuglingen sieht. Die akute Form geht mit verzögert auftretendem und beeindruckend starkem Erbrechen sowie daraus resultierendem raschem gastrointestinalem Flüssigkeitsverlust einher. Die chronische Verlaufsform tritt vor der Beikosteinführung auf und ist durch Erbrechen, Diarrhö und Gedeihstörung gekennzeichnet. Bei langanhaltender Symptomatik kann sich auch das Kind mit chronischem FPIES in einer kritischen Situation befinden, wenn Exsikkose, Elektrolytverschiebung und Azidose auftreten. Die häufigsten Auslöser in Deutschland sind Kuhmilch und Fisch. Die strikte Meidung des auslösenden Nahrungsmittels ist unerlässlich. Der Beratung kommt ein hoher Stellenwert zu. Sie beinhaltet die Punkte Beikosteinführung bei Säuglingen, Notfallmanagement, Prognose und den Zeitpunkt einer Toleranzüberprüfung. Die Erkrankung kann negative Auswirkungen auf die Lebensqualität und die psychosoziale Gesundheit der Patienten und Familien vermindern.