bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluation of trypsin-like immunoreactivity, pancreatic lipase immunoreactivity, cobalamin, and folate in zoo-housed African painted dogs (Lycaon pictus) at a North American zoological facility
Authors: Heinz Jessica Y. , Virgin Emily , Nollman Jennifer , Wenninger Michael R. 
Published: May 2024

Abstract

OBJECTIVE
Assess markers for pancreatic function and gastrointestinal malabsorption in African painted dogs (Lycaon pictus), including canine trypsin-like immunoreactivity (cTLI), canine pancreatic lipase immunoreactivity (cPLI), cobalamin, and folate at one North American facility.

ANIMALS
15 healthy African painted dogs held at one institution were sampled during routine health examinations.

METHODS
Blood was collected at routine health examinations, and serum was separated and stored until testing. Serum was analyzed for cTLI, cPLI, cobalamin, and folate. The results were evaluated for correlation to sex, age, and storage time of samples.

RESULTS
All individuals had cTLI and folate levels below normal reference ranges for domestic dogs (< 5.0 µg/L and < 7.7 µg/L, respectively). Cobalamin values were within or above reported domestic dog ranges, and cPLI values were within range as well. No analytes were significantly influenced by sex or time in storage, while cTLI was positively correlated with age.

CLINICAL RELEVANCE
cTLI and folate did not fall within normal domestic canid reference ranges in this population of healthy African painted dogs. Clinical interpretation of these values based on domestic canid recommendations would indicate clinical disease, which was not apparent in this population. Analytes for pancreatic function and malabsorption or gastrointestinal indicators, including cTLI, cPLI, and folate, in African painted dogs should be interpreted with caution when using domestic dog references ranges.
Enhancing Nutrient Digestibility and Antioxidant Efficacy in Piglets: The Impact of Fermented Rapeseed Meal Supplementation on Biochemical Parameters and Oxidative Stress Markers
Authors: Czech Anna , Woś Katarzyna , Muszyński Siemowit , Tomaszewska Ewa 
Published: May 2024

Abstract
This study aimed to investigate the effects of varying levels of dried fermented rapeseed meal (FRSM) on the nutrient digestibility and antioxidant efficacy in piglets. The experiment was conducted on 300 piglets, starting at 18 days of age. The primary experimental factor was the inclusion of FRSM in the diet, substituting mainly for post-extraction soybean meal and wheat. Two control groups were established: a positive control (PC) supplemented with 2500 ppm zinc oxide, and a negative control (NC) without additives. Additionally, four experimental groups were designated based on FRSM inclusion levels: FR-8 (8% FRSM), FR-12 (12% FRSM), FR-15 (15% FRSM), and FR-25 (25% FRSM). Results indicated a positive impact on nutrient absorption and redox processes, characterized by reduced efficiency of lipid peroxidation products such as malondialdehyde and lipid hydroperoxide in both blood and organs like the liver and intestines. From this perspective, the recommended inclusion of fermented rapeseed meal in piglet feed appears to be within the range of 8–12%
Are the Biodistribution and Metabolic Effects of Copper Nanoparticles Dependent on Differences in the Physiological Functions of Dietary Fibre?
Authors: Marzec Aleksandra , Cholewińska Ewelina , Fotschki Bartosz , Juśkiewicz Jerzy , Stępniowska Anna , Ognik Katarzyna 
Published: May 2024

Abstract
The aim of the study was to determine the effect of the recommended (6.5 mg/kg) or enhanced (13 mg/kg) level of CuNPs in the diet in combination with different types of dietary fibre – cellulose (control), inulin, pectin, or psyllium on the Cu biodistribution and level of selected minerals parameters in the blood of rats. Rats were randomly divided into 10 groups. The first two groups were fed control diets containing cellulose and a mineral mixture with standard or enhanced content of CuCO3. Experimental groups were fed a diet supplemented with CuNPs (6.5 or 13 mg/kg) and combined with different types of fibre (cellulose, pectin, inulin, or psyllium). After the feeding period blood, liver, brain, and thigh samples were collected. In the samples of water, diet, urine, faeces, liver, brain, and thigh the Cu content was determined to assess Cu biodistribution in the body. Additionally, the concentrations of minerals (Cu, P, Ca, Mg, Fe, and Zn) in the blood plasma samples were measured. The replacement of CuCO3 with CuNPs in the diet beneficially influenced the biodistribution of Cu in the body by reducing its excretion, improving its digestibility, and utilization, reducing its accumulation in the brain and muscle, and increasing levels of Ca, P, Mg, Zn and Fe in the blood. Increasing the level of CuNPs in the diet increased total Cu intake. The addition of pectin, inulin and psyllium to the diet with a high content of CuNPs significantly increased the excretion of Cu, with no negative effect on its digestibility, and utilization, and prevented its excessive accumulation in the brain and muscle of rats, especially in the case of inulin. The results suggest that the addition of dietary fibre to the diet of rats ensures homeostasis of this element in the case of excessive intake of CuNPs by modifying the bioavailability of Cu.
Capacitor-Based Active Cell Balancing for Electric Vehicle Battery Systems: Insights from Simulations
Authors: Marcin Daniel , Lacko Milan , Bodnár Dávid , Pancurák Lukáš 
Published: May 2024

Abstract
Cell balancing, a critical aspect of battery management in electric vehicles (EVs) and other applications, ensures a uniform state of charge (SOC) distribution among individual cells within a battery pack, enhancing performance and longevity while mitigating safety risks. This paper examines the effectiveness of capacitor-based active cell-balancing techniques using simulations under dynamic loading conditions. Utilising MATLAB and Simulink, various circuit topologies are evaluated, considering real-world cell parameters and open-circuit voltage (OCV) curve modelling. Results indicate that advanced configurations, such as double-tiered switched-capacitor balancing, offer improved balancing speed and efficiency compared to conventional methods. However, challenges such as transient events during charging and discharging phases underscore the need for further research. By leveraging simulations and experimental data, researchers can refine cell-balancing strategies, contributing to the development of safer, more efficient battery systems for EVs and beyond. This study underscores the importance of systematic analysis and optimisation in advancing cell-balancing technology for future energy-storage applications.
Posthumanistic transformation of the subject in the "virtual personal presence" at the ontological level
Authors: Nikonov Sergey Borisovich , E YUi-CHien' , Baichik Anna Vitalievna , Labush Nikolai Sergeevich 
Published: May 2024

The relevance of this research is due to the growing commercialization and integration of "virtual reality" (VR) technology into everyday life and science, which requires understanding its impact on the user's experience and the construction of human subjectivity, as well as the potential for modifying human interaction with the outside world. Scientists are discussing the potential of VR and expressing the need for it to open the doors to a new era for humanity as soon as possible. In this context, critical analysis and philosophical reflection on the development of virtual reality technology and the possible impact on human life become extremely relevant and topical. The subject of the study is the content and transformation of the subject of reality in the virtual space through mediatization. The object of the study is virtual reality The work is based on the deconstruction method based on the principles of interpreting what is read without distorting the meaning. With his help, the most significant and appropriate fragments were selected for scientific understanding and research of the phenomenon. As a result of the study, it was found that the informatization of the subject in the process of interaction with the virtual reality environment, a person as a subject is no longer an isolated substance, but expresses his existence through informatization.The concept of "virtual personal presence" provides a person with a framework for ontological expansion in the virtual dimension, therefore, the activity of virtual reality has a profound influence on the subjective construction of a person, characterized by posthumanistic features. Along with this, such influence at the level of ontology is mainly manifested in the virtualization and informatization of the subject. Virtualization of the subject not only shows the expansion of subjectivity in the virtual dimension, but also expresses that it always retains an ever-changing, plastic potential; informatization of the subject implies that in the activity of virtual reality, the subject represents his existence in the form of a specific information structure.
A clinical evaluation of low-level laser therapy for pain reduction in early treatment stages: A pilot study
Authors: Akash Lavate Priyanka , Kamble Pallavi , Agrawal Jiwanasha Manish , Vijapure Shashank , Alansari Reem Ahmed , Uzunçıbuk Hande , Marrapodi Maria Maddalena , Cicciù Marco , Minervini Giuseppe 
Published: May 2024

Objectives:This study aimed to clinically evaluate the efficacy of low-level laser therapy (LLLT) in reducing pain associated with orthodontic movement during the early stages of treatment.Material and Methods:A randomized controlled trial was conducted with 20 participants undergoing non-extraction orthodontic treatment. The laser group (LG,n= 10) received LLLT (808 nm, 100 mW) immediately after appliance installation, while the control group (CG,n= 10) received no pain control intervention. Pain levels were assessed using a visual analog scale (VAS) at 6, 24, 48, and 72 h till 7 days with an interval of 24 h. Statistical analyses included Chi-square tests and Mann–Whitney tests.Results:The LG consistently demonstrated significantly lower pain scores during chewing and at rest compared to the CG. After 6 h post-treatment, the median pain score on chewing in the LG was markedly lower than the CG (P< 0.001), a trend observed at each subsequent interval till 7 days. The comparison of spontaneous pain also favored the LG at various time points. Lower median VAS scores for pain on chewing among the LG and CG were zero and two, respectively, with a significant difference. The maximum median VAS scores for pain on chewing among the LG and CG were five and seven, respectively, with a significant difference.Conclusion:This study provides robust evidence supporting the effectiveness of LLLT in reducing orthodontic pain during the early stages of treatment. The sustained and significant reduction in pain scores, coupled with rigorous statistical analyses, emphasizes the potential of LLLT as a valuable adjunctive therapy in orthodontic practice.
Is endoscopic third ventriculostomy a viable treatment option for normal pressure hydrocephalus? A systematic review
Authors: Sohail Ayesha , Bajwa Mohammad Hamza , Virani Qurat-Ul-Ain , Tariq Anam , Hussain Nasr , Shamim Shahzad M. 
Published: May 2024

Background:
Endoscopic third ventriculostomy (ETV) is considered an alternative treatment for hydrocephalus and has become a standard of care for obstructive hydrocephalus. Recent studies have also explored its role in normal pressure hydrocephalus (NPH). We conducted a systematic review aiming to assess the outcomes of this minimally invasive endoscopic technique as a viable treatment option for NPH.

Methods:
A systematic literature search was performed using PubMed and Scopus databases, using iterations of search terms “Endoscopic third ventriculostomy,” “Idiopathic normal pressure hydrocephalus,” and “Normal pressure hydrocephalus.” To be eligible for inclusion in the review, articles had to report the usage of ETV as a primary treatment modality for NPH, report its outcomes, and be published in the English language.

Results:
Out of the 13 studies selected for qualitative synthesis, nine supported the use of ETV for NPH as an effective treatment option with improvement in the preoperative symptoms. Two studies favored shunt over ETV, stating that quality of life is better with VP shunt insertion. One study reported that ETV has higher perioperative mortality rates that outweigh its benefits. One study reported it to be an ineffective surgical option.

Conclusion:
The current review of evidence does not support the use of ETV for the treatment of NPH, except perhaps in a small subset of patients. These patients have a shorter duration of symptoms and a better preoperative neurological status. The lumbar infusion test and ventricular infusion test are modalities useful for selecting these candidates.
دور التنمية السياحية المستدامة في زيادة معدلات التشغيل
Authors: سليمان سارة , محمد ريبر 
Published: May 2024

تهدف الدراسة الى قياس أثر التنمية السياحية المستدامة في معدلات التشغيل لعدد من الدول السياحية المختارة وهي (السويد، سويسرا، فرنسا، نمسا، ايطاليا، اليونان ، المانيا، واسبانيا) وللمدة 1995-2021، ولغرض التعرف على أثر التنمية السياحية المستدامة في التشغيل في الدول المختارة، إعتمدت الدراسة لسلوب كمي وهو أنموذج الانحدار الذاتي للإبطائات الموزعة لمعطيات البانل (PNEL_ ARDEL, PMG)، وذلك لتقدير معلمات النموذج للمديين القصير والطويل، وأظهرت نتائج الدراسة أنه لايوجد تاثير معنوي ذو الدلالة الاحصائية بين معدلات التشغيل، والمتغيرات المفسرة له في المدى القصير، أما في المدى الطويل ، فقد أظهرت النتائج علاقة ايجابية ذات تأثير معنوي بين معدل التشغيل وكلا من الاستثمار الأجنبي المباشر، والإنفاق العام على التعليم، ومعدل نمو الصناعة، و معدل نمو الايرادات السياحية، في دول عينة الدراسة خلال المدى الذي غطته الدراسة. وبالنسبة للمتغيرات التي أثرت بشكل سلبي، فهي معدلات التضخم، وأما معدل النمو السكاني فكان له أثر سلبي ولكن غير معنوي. وتوصلت الدراسة الى عدة مقترحات من بينها: أن التنمية السياحية تتطلب التركيز على إستدامة المنشآت السياحية الموجودة بدلا من التركيز على زيادة عدد السياح، وإن التنمية السياحية المستدامة هي الخيار الأمثل لتحقيق التنمية الاقتصادية والإجتماعية في بلدان عينة الدراسة.
The ED50 of Remazolam Toluenesulfonate Combined with a Subthreshold Dose of Esketamine for Inhibiting Cardiovascular Response to Tracheal Intubation in Elderly Patients
Authors: Zhao Chunyan , Tang Yi , Chen Cibo , Xia Bingchun 
Published: May 2024

Objective: To explore the half-effective dose (ED50) of remazolam toluenesulfonate combined with subthreshold amounts of esketamine for inhibiting cardiovascular response to tracheal intubation in elderly patients. Method: We included 42 patients, aged 65–75, who required general anesthesia and single-lumen endotracheal intubation for elective surgery. The first patient was administered remazolam toluenesulfonate at a dose of 0.20 mg/kg. Once the patient lost consciousness, their alertness/sedation score (OAA/S score) was ≤ 1, and their BIS score was ≤ 60, and a subthreshold dose (0.3 mg/kg) of esketamine was given. The subsequent doses were adjusted using a sequential approach based on the cardiovascular response to tracheal intubation observed in the previous patient. The dose was modified in increments or decrements of 0.01 mg/kg. The ED50 and 95% CI of remazolam toluenesulfonate were calculated using the Dixon and Massey sequential distribution test method. Result: The inhibition of endotracheal intubation response was positively correlated with the dose of remazolam toluenesulfonate, and the depth of sedation could not be achieved when the amount was ≤ 0.22 mg/kg. The ED50 of remazolam toluenesulfonate combined with a subthreshold dose of esketamine in inhibiting cardiovascular response to tracheal intubation in elderly patients was 0.30 (0.28, 0.33) mg/kg. There was no statistically significant difference in blood pressure between the induction of anesthesia and before the operation. Conclusion: When compounded with 0.3 mg/kg esketamine, the ED50 of Remazolam toluenesulfonate in inhibiting cardiovascular response to endotracheal intubation in elderly patients was 0.30 mg/kg (95 % CI0.28–0.33 mg/kg).
hibridez comunicativa en imaginarios latinoamericanos en la cultura digital
Authors: Pacheco Díaz Angélica 
Published: May 2024

Este artículo aborda la hibridez de la comunicación para crear de manera interdisciplinaria narrativas de los imaginarios comunes y públicos de mujeres latinoamericanas, mediante una trama intercultural desde su espacio biográfico.
A partir de una investigación iberoamericana[1] que culminó en una publicación de experiencia transmedia y que se encuentra en etapa de divulgación en diversos espacios locales, nacionales e internacionales, se presenta en este artículo un análisis de esta narración intercultural y su hibridación cultural en imaginarios comunes.
Se aplicará una metodología basada en los análisis cualitativos de los contenidos de la comunicación intercultural del proyecto basado en un modelo circular narrativo de la trama diseñada para la construcción de narrativas con mujeres de América Latina.

[1] La investigación se denominó Imaginarios de las identidades híbridas latinoamericanas, desde las narrativas de la vida cotidiana de mujeres en la desigualdad de género en el marco del covid-19. Fue posible a través de la adjudicación de Fondos Internos de Investigación de la Universidad Viña del Mar, Chile, el año 2020.
As disputas em torno da Base Nacional Comum Curricular (BNCC) e a Pedagogia histórico-crítica
Authors: Melo Menezes Bernardes Viviane Margarida , Rodrigues Wildes Jesus 
Published: May 2024

Busca-se neste trabalho adentrar nos debates que envolvem a Base Nacional Comum Curricular (BNCC) publicada em 2018. Apresenta-se inicialmente algumas das perspectivas em que as disputas que envolvem as políticas públicas educacionais podem ser compreendidas, percebendo-as como disputas complexas que perpassam diferentes âmbitos teórico-metodológicos. Posteriormente, explora-se algumas das principais críticas ao documento a partir da Pedagogia histórico-crítica. Nas considerações finais, reflete-se brevemente o enfrentamento às problemáticas apontadas, salientando o papel da Pedagogia histórico-crítica e desafia-se à novas pesquisas sobre as políticas educacionais e as diretrizes da educação escolar no Brasil. A metodologia utilizada foi a pesquisa e a discussão bibliográfica, priorizando-se produções já referenciadas em outros estudos. Espera-se que este trabalho possa contribuir para uma introdução aos debates em torno da BNCC e, assim, na formação continuada dos profissionais que atuam na Educação Básica, buscando perspectivas que caminhe na direção de uma educação transformadora da realidade e promotora da justiça social.
Application of 4D flow MRI for exploring factors affecting haemodynamics of iliac veins in asymptomatic population
Authors: Nie Chengli , Tao Li , Chen Jiangwei , Yang Jianghu , Chen Zihui , Huang Wen 
Published: May 2024

BACKGROUND: Haemodynamics plays an important role in the development of vascular disease. There is currently a lack of studies evaluating the characteristics and affecting factors of the iliac vein haemodynamics in clinical practice. OBJECTIVE: The goal of this study was to use 4D flow MRI to explore the haemodynamic characteristics of iliac veins and its affecting factors in an asymptomatic population. METHODS: Thirty consecutive volunteers without venous-related symptoms or signs underwent four-dimensional postprocessing of their MRI images. Relevant parameters, the demographic data, common iliac vein-inferior vena cava angle, iliac vein area, tortuosity, iliac vein mean flow, mean velocity was computed and analysed. T tests and Spearman’s tests were used for analysing. A P value of 0.05 or less was considered significant. RESULTS: Height and iliac vein area were positively correlated with flow, while degree of stenosis, and common iliac-inferior vena cava angle were negatively correlated with that. Degree of stenosis was positively correlated with velocity, but the common iliac-inferior vena cava angle and iliac vein tortuosity were negatively correlated with that. The mean flow and velocity of iliac veins in females were lower than males. The mean flow and velocity of the left iliac veins were lower than those of the right. CONCLUSION: The height, gender, tortuosity, degree of stenosis, common iliac vein-inferior vena cava angle of the iliac vein are important factors that affect flow and velocity of the iliac veins. There were differences in haemodynamic parameters of the bilateral iliac veins.
Patient Selection for Active Surveillance for Small Renal Masses: A Systematic Review of the Literature
Authors: Distante Alfredo , Bertolo Riccardo , Campi Riccardo , Erdem Selcuk , Calio Anna , Palumbo Carlotta , Pavan Nicola , Ciccarese Chiara , Carbonara Umberto , Marchioni Michele , Roussel Eduard , Wu Zhenjie , Mulders Peter F.A. , Muselaers Constantijn H.J. 
Published: May 2024

BACKGROUND: The role of active surveillance (AS) has been recognized as a management strategy for localized small renal masses (SRMs). The EAU guidelines suggest AS can be offered to frail and/or comorbid patients diagnosed with SRM due to the low cancer-specific-mortality (CSM) and higher competing-cause mortality. As specific cut-offs defining the characteristics of frail and comorbid patients who may benefit from AS remain less clear, our objective is to conduct a systematic review aiming to identify potential characteristics that could assist physicians in shared decision-making. METHODS: The systematic literature review was conducted following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement. Two authors independently screened the literature according to the PICOs criteria previously outlined in our registered review protocol (via Pubmed, Embase, and the Cochrane Central Register of Controlled Trials), extracted data, and assessed the risk of bias, using Newcastle-Ottawa Scale. Studies that analyzed differences in patient’s tumor-related and molecular characteristics associated with any differences in growth rate (GR), overall survival (OS), cancer-specific survival (CSS), and metastasis-free survival (MFS), were considered eligible. RESULTS: Nineteen studies comprising a total of 5105 patients were analyzed. Patient-specific factors such as age and cardiovascular index, which demonstrated a predominant impact on OS, exhibited a high degree of consistency across the analyzed studies. Less concordance was found when exploring GR, with the main predictors being ethnicity, age, sex, comorbidity, symptoms, and eGFR. The analysis of tumor-related characteristics, such as tumor size, nephrometry score, and mass histology, among others, yielded contradictory outcomes concerning their impact on GR and CSS. CONCLUSION: Age, cardiovascular index, and chronic kidney disease have shown to be reliable predictors of OS. Nonetheless, significant debates persist regarding tumor characteristics or molecular markers that may influence survival and GR. Further research is awaited to shed light on the potential to identify prognostic factors. This would aid in pinpointing the subgroup of patients who could experience additional benefits from AS, potentially leading to a reduced risk of progression. It is imperative to standardize approaches to AS and reporting of results, as this will be pivotal for future quantitative analyses.
TEORÍA VOLCÁNICA
Authors: Holloway John 
Published: May 2024

ara nosotros que vivimos en Puebla, el Popocatépetl es un punto de referencia constante, visual y teóricamente.
El volcán es una belleza. Su belleza no se encuentra solamente en lo que se ve (la cumbre nevada, el humo levantándose de la nieve) sino en lo que no se ve: el corazón reprimido pero rebelde. Es el contraste que nos atrae, el contraste entre lo frío y lo caliente, entre la nieve por fuera y el horno por dento, la pasividad tranquila del exterior y la actividad frenética interna, la previsibilidad aparente por fuera y la imprevisibilidad total por dentro. Sobre todo, el volcán es testigo constante de la fuerza de lo reprimido.