bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association between thyroid function, thyroid autoimmunity, and state and trait factors of depression
Authors: van de Ven A. C. , Muntjewerff J.‐W. , Netea‐Maier R. T. , de Vegt F. , Ross H. A. , Sweep F. C. G. J. , Kiemeney L. A. , Vos P. E. , Buitelaar J. K. , Hermus A. R. M. M. , den Heijer M. , Janzing J. G. E. 
Published: April 2012

van de Ven AC, Muntjewerff J‐W, Netea‐Maier RT, de Vegt F, Ross HA, Sweep FCGJ, Kiemeney LA, Vos PE, Buitelaar JK, Hermus ARMM, den Heijer M, Janzing JGE. Association between thyroid function, thyroid autoimmunity, and state and trait factors of depression.Objective:  The aim of this study was to investigate whether thyroid function and thyroid peroxidase antibodies (TPOAb) are associated with depression, when using both state and trait parameters of depression.Method:  In 1125 participants of the Nijmegen Biomedical Study, thyroid‐stimulating hormone (TSH), free thyroxine (FT4), and TPOAb were measured twice. The Beck Depression Inventory (BDI), a self‐reported lifetime diagnosis of depression, and the neuroticism scale of the Eysenck Personality Questionnaire Revised Short Scale (EPQ‐RSS) were used to evaluate the presence of state and trait features of depression.Results:  We found no association between TSH and FT4 levels and BDI score, current depression, lifetime diagnosis of depression, and EPQ‐RSS neuroticism score. Subjects with TPOAb had higher EPQ‐RSS neuroticism scores in comparison with subjects without TPOAb, mean score 4.1 vs. 3.2 (regression coefficient 0.70; 95% CI 0.1–1.3; P‐value 0.02 after adjustment for confounders). The prevalence of a lifetime diagnosis of depression was higher in subjects with positive TPOAb in comparison with participants without TPOAb: 24.2% vs. 16.7% (relative risk 1.4; 95% CI 1.0–2.1; P‐value 0.04 after adjustment for confounders).Conclusion:  Thyroid peroxidase antibodies are positively associated with trait markers of depression. The presence of TPOAb may be a vulnerability marker for depression.
Blood graft composition after plerixafor injection in patients with NHL
Authors: Varmavuo Ville , Mäntymaa Pentti , Nousiainen Tapio , Valonen Piia , Kuittinen Taru , Jantunen Esa 
Published: April 2012

AbstractBackgroundPlerixafor is used to mobilize CD34+ hematopoietic stem cells from bone marrow to circulation. Limited data are available in regard to graft cellular content collected after plerixafor.ObjectivesThe aim of this study was to assess effects of plerixafor added to chemomobilization on graft CD34+ cell subclasses, lymphocyte subsets, engraftment, and post‐transplant course in non‐Hodgkin lymphoma (NHL) patients.MethodsThirty‐four patients with NHL were included. All patients received chemotherapy plus G‐CSF to mobilize stem cells. Nineteen patients received plerixafor pre‐emptively owing to poor mobilization or poor collection yields. The rest of the patients constituted the control group. Flow cytometric analyzes were performed from cryopreserved graft samples. Also, data on post‐transplant engraftment and outcome were collected.ResultsThe proportion of primitive stem cells (CD34+ CD133+ CD38−) was significantly higher after the plerixafor injection when compared to the first collection in the control group. The amount of T cells (CD3+), helper (CD3+ CD4+) T subsets, and suppressor (CD3+ CD8+) T subsets in the graft was all significantly higher in the plerixafor group. Also, the amount of NK cells (CD3− CD16/56+) was higher. Engraftment after high‐dose therapy was comparable between the groups, but leukocyte and platelet count at 6 months were higher in patients receiving plerixafor‐mobilized grafts.ConclusionPlerixafor, when used pre‐emptively in addition to chemomobilization, seems to mobilize more primitive CD34+ stem cells, T lymphocytes, and NK cells. Whether these differences are associated with immune reconstitution, long‐term engraftment, or patient outcomes needs to be evaluated in larger patient groups with longer follow‐up.
Unexpected extra‐renal effects of loop diuretics in the preterm neonate
Authors: Cotton Robert , Suarez Sandra , Reese Jeff 
Published: April 2012

AbstractThe loop diuretics furosemide and bumetanide are commonly used in neonatal intensive care units (NICUs). Furosemide, because of its actions on the ubiquitous Na+–K+–2Cl− isoform cotransporter and its promotion of prostanoid production and release, also has non‐diuretic effects on vascular smooth muscle, airways, the ductus arteriosus and theoretically the gastrointestinal tract. Loop diuretics also affect the central nervous system through modulation of the GABA‐A chloride channel.Conclusion:  The loop diuretics have a variety of biological effects that are potentially harmful as well as beneficial. Care should be taken with the use of these agents because the range of their effects may be broader than the single action sought by the prescribing physician.
Immunity after (re)vaccination of paediatric patients following haematopoietic stem cell transplantation
Authors: Olkinuora Helena , Käyhty Helena , Davidkin Irja , Roivainen Merja , Ölander Rose‐Marie , Kantele Jussi M , Siitonen Sanna , Vettenranta Kim 
Published: April 2012

AbstractAims:  Loss of specific immunity follows allogeneic haematopoietic stem cell transplantation (HSCT) in the majority of cases. Responses to (re)vaccinations can be used as indicators of a functional immunological recovery.Methods:  Twenty‐three paediatric recipients of HSCT were enrolled in a single centre setting and responses to scheduled immunizations analysed.Results:  Immunity to vaccine‐preventable diseases was impaired post HSCT, but (re)vaccinations induced protective responses in 59–100%, depending on the vaccine, regardless of prior graft‐versus‐host disease (GVHD) history.Conclusion:  Despite the marked impact of moderate to severe chronic prior GVHD on both the qualitative and quantitative T‐cell recovery post allogenic HSCT, most paediatric recipients of allogeneic stem cell grafts appear to attain protective antibody levels after immunization.
Poisoning mortality in Danish children and adolescents, 1970–2006 – a registry‐based study
Authors: Jacobsen Peter , Juel Knud 
Published: April 2012

AbstractAim:  To study poisoning mortality from birth to the end of teenage.Methods:  Registry study within the Danish population including all deaths from poisoning in the 0–19‐year age groups for the years 1970–2006.Results:  Poisoning mortality was age dependent with a modest peak in preschool children because of accidents and a very steep increase from 0.1/105 person years (p.y.) at 12 years to 6.1/105 p.y. at 19 years. Accidents, suicide and undetermined manner of death all contributed to the increase. A significant proportion of accidental and undetermined manner of death was caused by opioides and probably abuse related. During the study period, mortality decreased by more than 50% with all manners of death contributing significantly to the decline. Carbon monoxide poisoning was the overall dominating cause of death and contributed most to reduction in mortality. Poisoning death caused by opioides and unspecified drugs was unchanged over time.Conclusion:  Poisoning mortality among the youngest Danish children was dominated by accidental poisonings. During teenage, the level and pattern of adults was approached with respect to suicidal and abuse related deaths. A fall in mortality since mid‐eighties was explained by fewer deaths from carbon monoxide poisoning.
Simultaneous occurrence of foetal and neonatal alloimmune thrombocytopenia and neonatal neutropenia due to maternal neutrophilic autoantibodies: a case study and review of the literature
Authors: Taaning Ellen , Jensen Lise , Varming Kim 
Published: April 2012

AbstractFoetal and neonatal alloimmune thrombocytopenia (FNAIT) and neonatal neutropenia caused by maternal autoantibodies against neutrophils are rare disorders. We describe a newborn with severe thrombocytopenia and intracerebral bleeding caused by maternal anti‐HPA‐3a alloantibodies and mild neutropenia caused by maternal autoantibodies against HNA‐1b. This appears to be the first case of simultaneous occurrence of these two conditions.Conclusion:  This case report and review of the literature demonstrate that anti‐HPA‐3a antibodies can be overlooked by standard assays.
Simple external rotation of the leg increases the size and accessibility of the femoral vein
Authors: Read Hamish , Holdgate Anna , Watkins Stuart 
Published: April 2012

AbstractObjective: To determine if external rotation of the leg increases the size and accessibility of the femoral vein compared with a neutral position.Methods: One hundred patients presenting to a tertiary teaching hospital were prospectively recruited. The right common femoral vein of each subject was scanned with a linear probe (5–10 MHz) inferior to the inguinal ligament, with the leg in a neutral position and then in the externally rotated position. The transverse diameter of the femoral vein, the accessible diameter of the vein (lying medial to the femoral artery) and the depth of the vein were measured.Results: The mean diameter of the femoral vein in the externally rotated leg was greater than with the leg in the neutral position (15.4 mm vs 13.8 mm); the mean difference was 1.6 mm (95% CI 1.3–1.9). The mean accessible diameter of the femoral vein was larger with the leg externally rotated (13.8 mm vs 11.7 mm, mean difference 2.1 mm, 95% CI 1.8–2.5). The depth from the skin to the femoral vein was less with the leg in external rotation (20.9 mm vs 22.6 mm, mean difference 1.7 mm, 95% CI 1.2–2.2). The mean diameter and depth were greater in patients with overweight or obese body mass index (BMI) measurements in both leg positions. The increase in femoral vein diameter and accessibility with external rotation was observed in all BMI groups.Conclusion: The total and accessible femoral vein diameter is increased and the surface depth of the vein is decreased by placing the leg in external rotation compared with the neutral position.
A Comparison of the Potency of a Novel Bispyridinium Oxime K203 and currently available Oximes (Obidoxime, HI‐6) to Counteract the Acute Neurotoxicity of Sarin in Rats
Authors: Kassa Jiri , Misik Jan , Karasova Jana Zdarova 
Published: April 2012

AbstractThe neuroprotective effects of a newly developed oxime K203 and currently available oximes (obidoxime, HI‐6) in combination with atropine in rats poisoned with sarin were studied. The sarin‐induced neurotoxicity was monitored using a functional observatory battery at 2 hr after sarin challenge. The results indicate that the potency of a novel bispyridinium oxime K203 to counteract sarin‐induced neurotoxicity is relatively low and roughly corresponds to the neuroprotective efficacy of obidoxime. Among tested oximes, the oxime HI‐6 seems to be significanlty more efficacious to counteract acute neurotoxicity of sarin than commonly used obidoxime and a newly developed oxime K203. Thus, the oxime K203 does not provide any beneficial effect for the antidotal treatment of acute poisoning with sarin in comparison with the oxime HI‐6 that should be considered to be the best oxime for antidotal treatment of acute sarin poisonings.
The preimaginal stages of the ensign wasp Evania appendigaster (Hymenoptera, Evaniidae), a cockroach egg predator
Authors: Fox Eduardo Gonçalves Paterson , Solis Daniel Russ , Rossi Mônica Lanzoni , Eizemberg Roberto , Taveira Luiz Pilize , Bressan‐Nascimento Suzete 
Published: April 2012

AbstractEvania appendigaster is a cosmopolitan wasp that deposits eggs in the oothecae of some species of cockroaches; its larvae then consume the cockroach eggs and embryos. It is a candidate for the biological control of cockroaches, but little is known about its basic biology. Here we describe the external morphology of all immature stages of E. appendigaster and compare them with the larvae of related species. The life cycle of E. appendigaster includes three larval instars, each with 13 body segments. Their mouthparts were generally reduced, except for the mandibles, which were always sclerotized and toothed, and were especially robust in second‐instar larvae. Antennal and mouthpart sensilla were basiconic and difficult to observe. Larvae of E. appendigaster are similar in form to other described evaniid larvae, but quite different from the two available descriptions of larvae of gasteruptiid and aulacid wasps. Further descriptions of evaniid larvae will be useful in determining how widespread this morphology is within the family, and in understanding phylogenetic relationships within Hymenoptera.
Deforestation and the Environmental Kuznets Curve in Developing Countries: A Panel Smooth Transition Regression Approach
Authors: Chiu Yi‐Bin 
Published: April 2012

Deforestation is a serious environmental problem in many developing countries. This study re‐examines whether the Environmental Kuznets Curve (EKC) relationship between deforestation and real income exists for 52 developing countries during the 1972–2003 period by applying the recently developed panel smooth transition regression (PSTR) model. This paper also considers the potential endogeneity biases and other explanatory variables as a robustness check of the EKC hypothesis. The empirical results indicate the existence of a strong threshold effect between deforestation and real income, and that evidence of the EKC hypothesis for deforestation is apparent. Along with an increase in real income, deforestation increases initially, and after reaching certain income levels, deforestation drops. The turning points are US$3,021 and US$3,103, which the PSTR model endogenously determines.La déforestation constitue un problème environnemental préoccupant dans de nombreux pays en développement. Dans le présent article, nous avons tenté d’établir s’il existe ou non une relation en U inversé (courbe de Kuznets) entre la déforestation et le revenu réel, en appliquant la nouvelle méthode d’estimation d’effets de seuil avec transition lisse en panel (PSTR) à un échantillon de 52 pays en développement au cours de la période de 1972 à 2003. Nous avons également examiné les biais endogènes possibles et d’autres variables explicatives pour vérifier la robustesse de l’hypothèse de Kuznets. Les résultats empiriques montrent qu’il existe un effet de seuil robuste entre la déforestation et le revenu réel, et que l’évidence de l’hypothèse de Kuznets dans le cas de la déforestation est apparente. Lorsque le revenu réel augmente, la déforestation augmente aussi, mais lorsque le revenu atteint certains niveaux, la déforestation diminue. Les points de retournement sont de 3 021 $US et de 3 103 $US, ce que la méthode PSTR a déterminé de manière endogène.
The Effect of Different Heating Patterns on Vacuum Freeze‐Drying of Litchi Pulp
Authors: Qiao Fang , Fang Changfa , Huang Luelue , Zhang Shufei 
Published: April 2012

ABSTRACTThree heating patterns, constant temperature, temperature programmed and programmed cooling process were applied to freeze‐drying (FD) the litchi pulp in order to obtain the optimal FD heating technology. The results show that the three patterns all could be used to FD litchi pulp while the appearance was maintained well. The drying time of FD litchi pulp using programmed cooling process was the shortest among the three optimal heating patterns and the drying time was reduced by 15.8 and 11.6% comparing that of FD using constant temperature and temperature programmed. Higher temperature can be applied at the early primary drying stage when the temperature of litchi pulp is under the eutectic temperature and at secondary drying stage but should not be used at the later primary drying stage.PRACTICAL APPLICATIONSVacuum FD is widely used in food, protein and drug drying. It is still the best drying method to obtain high‐quality biological products. The objective of this paper was to optimize the FD process of litchi pulp. The significance of this research can improve the efficiency of FD in litchi pulp drying. Throughout the trial, the production‐scale vacuum freeze‐dryer was used, which means that the FD process can provide technological support to produce freeze‐dried litchi pulp. In addition, it can also provide a reference for other fruits and vegetables' FD process optimization.
Assessment of the value of quantitative thyroid scintigraphy for determination of thyroid function in dogs
Authors: Shiel R. E. , Pinilla M. , McAllister H. , Mooney C. T. 
Published: April 2012

Objective: To assess the value of thyroid scintigraphy to determine thyroid status in dogs with hypothyroidism and various non‐thyroidal illnesses.Methods: Thyroid hormone concentrations were measured and quantitative thyroid scintigraphy performed in 21 dogs with clinical and/or clinicopathological features consistent with hypothyroidism.Results: In 14 dogs with technetium thyroidal uptake values consistent with euthyroidism, further investigations supported non‐thyroidal illness.In five dogs with technetium thyroidal uptake values within the hypothyroid range, primary hypothyroidism was confirmed as the only disease in four. The remaining dog had pituitary‐dependent hyperadrenocorticism.Two dogs had technetium thyroidal uptake values in the non‐diagnostic range. One dog had iodothyronine concentrations indicative of euthyroidism. In the other, a dog receiving glucocorticoid therapy, all iodothyronine concentrations were decreased.Markedly asymmetric technetium thyroidal uptake was present in two dogs. All iodothyronine concentrations were within reference interval but canine thyroid stimulating hormone concentration was elevated in one. Non‐thyroidal illness was identified in both cases.ClinicalSignificance: In dogs, technetium thyroidal uptake is a useful test to determine thyroid function. However, values may be non‐diagnostic, asymmetric uptake can occur and excess glucocorticoids may variably suppress technetium thyroidal uptake and/or thyroid hormone concentrations. Further studies are necessary to evaluate quantitative thyroid scintigraphy as a gold standard method for determining canine thyroid function.
Severe dermatophytosis due to Trichophyton mentagrophytes var. interdigitale in flocks of green iguanas (Iguana iguana)
Authors: Khosravi A. R. , Shokri H. , Rostami A. , Tamai I. A. , Erfanmanesh A. , Memarian I. 
Published: April 2012

Objective: To describe the clinical, mycological, histopathological and molecular findings in green iguanas (Iguana iguana) affected with severe dermatophytosis in selected flocks near Tehran, Iran.Materials and Methods: Samples were collected from the scales of skin lesions and tested with standard mycological methods and dermatophyte‐specific PCR amplification analysis using the primer pair for the chitin synthase 1(CHS1) gene.Results: All iguanas were definitively diagnosed with dermatophytosis using both traditional and molecular diagnostic methods. PCR fingerprinting profiles using simple repetitive (GACA)4 primers showed that all diagnosed iguanas had the same pattern profile. Intraspecific variability was not observed for these isolates. Oligonucleotide sequencing of CHS1 gene PCR products confirmed Trichophyton mentagrophytes var. interdigitale as the infectious agent.Clinical Significance: These results suggest that (GACA)4‐based PCR has utility both as a simple and rapid method for identification of dermatophyte species and for differentiation of T. mentagrophytes variants.
Enactments in Emotionally Focused Couple Therapy: Shaping Moments of Contact and Change
Authors: Tilley Douglas , Palmer Gail 
Published: April 2012

Emotionally focused couple therapy (EFT) uses enactments to shape responsive attachment‐significant contact and to change couple interaction. In this article, we show how EFT enactments differ from enactments in other therapy approaches, present a theory of EFT enactments, a model for creating EFT enactments, and an extended case example of an EFT enactment.Video Abstract
The IUCN global assessments: partnerships, collaboration and data sharing for biodiversity science and policy
Authors: Lacher Thomas E. , Boitani Luigi , da Fonseca Gustavo A.B. 
Published: April 2012

AbstractThe development of standards, data sharing, and initiatives like the Global Biodiversity Information Facility and others have advanced research in many fields, including in conservation of biodiversity. Global assessments of extinction risk to species have been completed by IUCN for multiple taxa. The IUCN global assessments have had a major impact on conservation science and practice as well as biodiversity funding mechanisms though the Global Environment Facility, the World Bank, and the Critical Ecosystem Partnership Fund (CEPF). A signature of the assessments is a process of sustained interaction between conservation organizations and the research and academic community, effectively integrating science and policy on global scale. The model relies on several critical components: openness of the conservation community to scientific input and debate, engagement of the scientific community, conservation organization mediated data collation, and data sharing with ease of access. This model can be applied to other challenges to conserve biodiversity and assess how biodiversity loss affects the well‐being of societies across the world. The recognition of the importance of biodiversity in meeting the Millennium Development Goals and the recognition of the failure to meet the 2010 Biodiversity Target illustrate the gap between what needs to be achieved and our current trajectory.
Continual Transcranial Doppler in the Monitoring of Hemodynamic Change following Aneurysmal Subarachnoid Hemorrhage
Authors: Bian Li‐Heng , Liu Li‐Ping , Wang Wen‐Juan , Wang Chun‐Xue , Yang Zhong‐Hua , Song Xin‐Jie , Wen Miao , Liu Gai‐Fen , Zhao Xing‐Quan 
Published: April 2012

SUMMARY Aims: To analyze and compare the value of different treatment methods for acute aneurysmal subarachnoid hemorrhage (aSAH)‐related vasospasm. Cerebral hemodynamic variables’ changes were evaluated by transcranial Doppler (TCD) in aSAH patients within 14 days after onset. Methods: Thirty aSAH patients were enrolled in the study within 72 h after onset. Baseline CT and TCD were used for assessment. Patients were divided into three groups according to SAH severity and patients’ discretion: nonsurgical group, endovascular coiling, and neurosurgical clipping. TCD hemodynamic parameters were measured and Lindegaard index was calculated daily from onset to 14th day after SAH. The group mean cerebral blood velocity (MBFV) and Lindegaard index were compared using repeated measures analysis of variance (reANOVA). Least Significant Difference (LSD) test was used for post hoc comparison. All 30 patients were followed for 90 days after onset for outcome assessment. Results: The values of MBFV and Lindegaard index of anterior cerebral artery (ACA)/middle cerebral artery (MCA) from high to low is nonsurgical group, clipping and coiling (ACA: P= 0.0001/P= 0.006; MCA: P= 0.243/P= 0.317). Conclusions: These results indicate that both neurosurgical clipping and endovascular coiling management may relieve the severity of cerebral vasospasm in acute aSAH.