bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prevention of oxaliplatin‐induced mechanical allodynia and neurodegeneration by neurotropin in the rat model
Authors: Kawashiri Takehiro , Egashiral Nobuaki , Watanabe Hitomi , Ikegami Yoko , Hirakawa Shingo , Mihara Yuki , Yano Takahisa , Ikesue Hiroaki , Oishi Ryozo 
Published: September 2010

AbstractOxaliplatin is a key drug for colorectal cancer, but it causes acute peripheral neuropathy (triggered by cold) and chronic neuropathy (sensory and motor neuropathy) in patients. Neurotropin, a non‐protein extract from the inflamed rabbit skin inoculated with vaccinia virus, has been used to treat various chronic pains. In the present study, we investigated the effect of neurotropin on the oxaliplatin‐induced neuropathy in rats.Repeated administration of oxaliplatin caused cold hyperalgesia from Day 5 to Day 29 and mechanical allodynia from Day 15 to Day 47. Repeated administration of neurotropin relieved the oxaliplatin‐induced mechanical allodynia but not cold hyperalgesia, and inhibited the oxaliplatin‐induced axonal degeneration in rat sciatic nerve. Neurotropin also inhibited the oxaliplatin‐induced neurite degeneration in cultured pheochromocytoma 12 (PC12) and rat dorsal root ganglion (DRG) cells. On the other hand, neurotropin did not affect the oxaliplatin‐induced cell injury in rat DRG cells. These results suggest that repeated administration of neurotropin relieves the oxaliplatin‐induced mechanical allodynia by inhibiting the axonal degeneration and it is useful for the treatment of oxaliplatin‐induced neuropathy clinically.
Signs of left heart volume overload in severely anaemic cats
Authors: Wilson Helen E. , Jasani Shailen , Wagner Tobias B. , Benigni Livia , Milne Joanna R. , Stokes Alison L. , Luis-Fuentes Virginia 
Published: September 2010

Anaemia induces haemodynamic compensatory mechanisms resulting in volume overload and increased left heart dimensions in humans and dogs. The aims of this retrospective study were to investigate the effects of anaemia on echocardiographic left heart dimensions, vertebral heart size (VHS) and radiographic evidence of congestive heart failure (CHF) in cats. Fifteen cats fulfilled the inclusion criteria and were classified as mildly anaemic (haematocrit (Hct)>18–24%) or severely anaemic (Hct≤18%). Eight out of eight severely anaemic cats had left atrial enlargement compared with 1/6 mildly anaemic cats (P<0.005) and severely anaemic cats also had a larger median left ventricular end-diastolic diameter (1.80 cm versus 1.27 cm, respectively; P<0.05). No difference was found between the groups in VHS or frequency of radiographic signs of CHF. Despite the small sample size, these preliminary findings suggest that severely anaemic cats are more likely to have enlarged left heart dimensions than mildly anaemic cats.
Performance evaluation of harvest control rules for Pacific herring management in British Columbia, Canada
Authors: Cleary J. S. , Cox S. P. , Schweigert J. F. 
Published: September 2010

AbstractCleary, J. S., Cox, S. P., and Schweigert, J. F. 2010. Performance evaluation of harvest control rules for Pacific herring management in British Columbia, Canada. – ICES Journal of Marine Science, 67: 2005–2011. Despite application of a harvest control rule (HCR) since 1986, abundance of several Pacific herring (Clupea pallasi) stocks in British Columbia, Canada, are currently below levels considered adequate for exploitation. An alternative HCR, based on default limit and upper stock reference (USR) points at 0.4 BMSY and 0.8 BMSY, was recently developed under Canada's precautionary fisheries management policy. We simulated the Pacific herring fishery management system to examine whether (i) realized fishery performance over the past 10 years is an expected consequence of applying the existing herring HCR (with a single lower reference point) and (ii) performance could be improved by adopting the Department of Fisheries and Oceans new HCR with limit and USR points. Both HCRs successfully rebuilt stocks to sustainable levels under a high-productivity scenario, but performed poorly when stock productivity was low. The two HCRs were sensitive to stock productivity, because the effect of a target harvest rate (20%) that is independent of productivity was much larger than the effects of biomass reference-point choices. We therefore recommend further research on estimating reference points and sustainable harvest rates for Pacific herring, so that HCRs may be made more responsive to changes in productivity.
Digital Gene Expression Signatures for Maize Development
Authors: Eveland Andrea L. , Satoh-Nagasawa Namiko , Goldshmidt Alexander , Meyer Sandra , Beatty Mary , Sakai Hajime , Ware Doreen , Jackson David 
Published: September 2010

Abstract
Genome-wide expression signatures detect specific perturbations in developmental programs and contribute to functional resolution of key regulatory networks. In maize (Zea mays) inflorescences, mutations in the RAMOSA (RA) genes affect the determinacy of axillary meristems and thus alter branching patterns, an important agronomic trait. In this work, we developed and tested a framework for analysis of tag-based, digital gene expression profiles using Illumina’s high-throughput sequencing technology and the newly assembled B73 maize reference genome. We also used a mutation in the RA3 gene to identify putative expression signatures specific to stem cell fate in axillary meristem determinacy. The RA3 gene encodes a trehalose-6-phosphate phosphatase and may act at the interface between developmental and metabolic processes. Deep sequencing of digital gene expression libraries, representing three biological replicate ear samples from wild-type and ra3 plants, generated 27 million 20- to 21-nucleotide reads with frequencies spanning 4 orders of magnitude. Unique sequence tags were anchored to 3′-ends of individual transcripts by DpnII and NlaIII digests, which were multiplexed during sequencing. We mapped 86% of nonredundant signature tags to the maize genome, which associated with 37,117 gene models and unannotated regions of expression. In total, 66% of genes were detected by at least nine reads in immature maize ears. We used comparative genomics to leverage existing information from Arabidopsis (Arabidopsis thaliana) and rice (Oryza sativa) in functional analyses of differentially expressed maize genes. Results from this study provide a basis for the analysis of short-read expression data in maize and resolved specific expression signatures that will help define mechanisms of action for the RA3 gene.
Regulatory Network Identification by Genetical Genomics: Signaling Downstream of the Arabidopsis Receptor-Like Kinase ERECTA
Authors: Terpstra Inez R. , Snoek L. Basten , Keurentjes Joost J.B. , Peeters Anton J.M. , Van den Ackerveken Guido 
Published: September 2010

Abstract
Gene expression differences between individuals within a species can be largely explained by differences in genetic background. The effect of genetic variants (alleles) of genes on expression can be studied in a multifactorial way by the application of genetical genomics or expression quantitative trait locus mapping. In this paper, we present a strategy to construct regulatory networks by the application of genetical genomics in combination with transcript profiling of mutants that are disrupted in single genes. We describe the network identification downstream of the receptor-like kinase ERECTA in Arabidopsis (Arabidopsis thaliana). Extending genetical genomics on the Landsberg erecta/Cape Verde Islands (Ler/Cvi) recombinant inbred population with expression profiling of monogenic mutants enabled the identification of regulatory networks in the so far elusive ERECTA signal transduction cascade. We provide evidence that ERECTA is the causal gene for the major hotspot for transcript regulation in the Arabidopsis Ler/Cvi recombinant inbred population. We further propose additional genetic variation between Ler and Cvi in loci of the signaling pathway downstream of ERECTA and suggest candidate genes underlying these loci. Integration of publicly available microarray expression data of other monogenic mutants allowed us to link ERECTA to a downstream mitogen-activated protein kinase signaling cascade. Our study shows that microarray data of monogenic mutants can be effectively used in combination with genetical genomics data to enhance the identification of genetic regulatory networks.
Genome Structures and Halophyte-Specific Gene Expression of the Extremophile Thellungiella parvula in Comparison with Thellungiella salsuginea (Thellungiella halophila) and Arabidopsis
Authors: Oh Dong-Ha , Dassanayake Maheshi , Haas Jeffrey S. , Kropornika Anna , Wright Chris , d’Urzo Matilde Paino , Hong Hyewon , Ali Shahjahan , Hernandez Alvaro , Lambert Georgina M. , Inan Gunsu , Galbraith David W. , Bressan Ray A. , Yun Dae-Jin , Zhu Jian-Kang , Cheeseman John M. , Bohnert Hans J. 
Published: September 2010

Abstract
The genome of Thellungiella parvula, a halophytic relative of Arabidopsis (Arabidopsis thaliana), is being assembled using Roche-454 sequencing. Analyses of a 10-Mb scaffold revealed synteny with Arabidopsis, with recombination and inversion and an uneven distribution of repeat sequences. T. parvula genome structure and DNA sequences were compared with orthologous regions from Arabidopsis and publicly available bacterial artificial chromosome sequences from Thellungiella salsuginea (previously Thellungiella halophila). The three-way comparison of sequences, from one abiotic stress-sensitive species and two tolerant species, revealed extensive sequence conservation and microcolinearity, but grouping Thellungiella species separately from Arabidopsis. However, the T. parvula segments are distinguished from their T. salsuginea counterparts by a pronounced paucity of repeat sequences, resulting in a 30% shorter DNA segment with essentially the same gene content in T. parvula. Among the genes is SALT OVERLY SENSITIVE1 (SOS1), a sodium/proton antiporter, which represents an essential component of plant salinity stress tolerance. Although the SOS1 coding region is highly conserved among all three species, the promoter regions show conservation only between the two Thellungiella species. Comparative transcript analyses revealed higher levels of basal as well as salt-induced SOS1 expression in both Thellungiella species as compared with Arabidopsis. The Thellungiella species and other halophytes share conserved pyrimidine-rich 5′ untranslated region proximal regions of SOS1 that are missing in Arabidopsis. Completion of the genome structure of T. parvula is expected to highlight distinctive genetic elements underlying the extremophile lifestyle of this species.
Classification in a social world: bias and trust
Authors: Mai Jens‐Erik 
Published: September 2010

PurposeThe purpose of this paper is to establish pluralism as the basis for bibliographic classification theory and practice and examine the possibility of establishing trustworthy classifications.Design/methodology/approachThe paper examines several key notions in classification and extends previous frameworks by combining an explanation‐based approach to classification with the concepts of cognitive authority and trust.FindingsThe paper presents an understanding of classification that allows designers and editors to establish trust through the principle of transparency. It demonstrates that modern classification theory and practice are tied to users' activities and domains of knowledge and that trustworthy classification systems are in close dialogue with users to handle bias responsible and establish trust.Originality/valueThe paper establishes a foundation for exploring trust and authority for classification systems.
Mental models of the bibliographic universe. Part 1: mental models of descriptions
Authors: Pisanski Jan , Žumer Maja 
Published: September 2010

PurposeThe paper aims to present the results of the first two tasks of a user study looking into mental models of the bibliographic universe and especially their comparison to the Functional Requirements for Bibliographic Records (FRBR) conceptual model, which has not yet been user tested.Design/methodology/approachThe paper employes a combination of techniques for eliciting mental models and consisted of three tasks, two of which, card sorting and concept mapping, are presented herein. Its participants were 30 individuals residing in the general area of Ljubljana, Slovenia.FindingsCumulative results of concept mapping show a strong resemblance to FRBR. Card sorts did not produce conclusive results. In both tasks, participants paid special attention to the original expression, indicating that a special place for it should be considered.Research limitations/implicationsThe study was performed using a relatively small sample of participants living in a geographically limited space using relatively straight‐forward examples.Practical implicationsSome solid evidence is provided for adoption of FRBR as the conceptual basis for cataloguing.Originality/valueThis is the first widely published user study of FRBR, applying novel methodological approaches in the field of Library and Information Science.
Mental models of the bibliographic universe. Part 2: comparison task and conclusions
Authors: Pisanski Jan , Žumer Maja 
Published: September 2010

PurposeThe paper aims to provide some insight into mental models of the bibliographic universe and how they compare with functional requirements for bibliographic records (FRBR) as a conceptual model of the bibliographic universe.Design/methodology/approachTo get a more complete picture of the mental models, different elicitation techniques were used. The three tasks of the paper were: card‐sorting, concept mapping and comparison task. The paper deals with comparison task, which consisted of interviews and rankings, and provides a discussion of the results of the paper as a whole.FindingsResults of the ranking part of the comparison task confirm the findings of concept mapping task. In both cases, while there are individual differences between mental models, on average they gravitate towards FRBR.Research limitations/implicationsThis is a small study and it provides only a glimpse of the implications of using FRBR as a conceptual basis for cataloguing. More FRBR‐related user studies are needed, including similar studies on different groups of individuals and different types of materials, as well as practical studies of user needs and user interfaces.Practical implicationsThe results of this study are the first user‐tested indication of the validity of FRBR as a conceptual basis for the future of cataloguing.Originality/valueThis is the first published paper of mental models of the bibliographic universe and uses a unique combination of mental model elicitation techniques.
The h‐index: a broad review of a new bibliometric indicator
Authors: Norris Michael , Oppenheim Charles 
Published: September 2010

PurposeThis review aims to show, broadly, how the h‐index has become a subject of widespread debate, how it has spawned many variants and diverse applications since first introduced in 2005 and some of the issues in its use.Design/methodology/approachThe review drew on a range of material published in 1990 or so sources published since 2005. From these sources, a number of themes were identified and discussed ranging from the h‐index's advantages to which citation database might be selected for its calculation.FindingsThe analysis shows how the h‐index has quickly established itself as a major subject of interest in the field of bibliometrics. Study of the index ranges from its mathematical underpinning to a range of variants perceived to address the indexes' shortcomings. The review illustrates how widely the index has been applied but also how care must be taken in its application.Originality/valueThe use of bibliometric indicators to measure research performance continues, with the h‐index as its latest addition. The use of the h‐index, its variants and many applications to which it has been put are still at the exploratory stage. The review shows the breadth and diversity of this research and the need to verify the veracity of the h‐index by more studies.
Information literacy and knowledge management at work
Authors: Toledano O'Farrill Rubén 
Published: September 2010

PurposeThe purpose of this paper is to explore theoretically and empirically the concept of workplace information literacy (IL) and its connections to knowledge management (KM), and to examine the applicability of the mainstream institutional IL frameworks (American Library Association, The Australian and New Zealand Institute for IL, The Society of College, National and University Libraries, The UK Chartered Institute of Library Professionals, etc.) to the workplace environment.Design/methodology/approachPhenomenographic study of conceptions of effective information use of frontline staff at NHS24, which are discussed with respect to organizational characteristics of NHS Scotland and against the background of the two theoretical concepts: KM and IL.FindingsThe paper shows that the main institutional IL frameworks do not properly reflect some important ways in which information is used by participants in the study, particularly the use of people as information sources and the social sense making and interpretation of the value of information and its application in the workplace environment.Research limitations/implicationsThe results from this qualitative study of a small population can be useful inasmuch as they highlight characteristics of workplace IL that may be relevant in several organizational settings, as well as presenting a critical analysis of the IL frameworks developed by librarians in regard to their applicability to workplace settings.Practical implicationsThe paper highlights the importance of developing organization‐specific guidelines for IL development, endorsing views of learning and information use grounded in socio‐constructive perspectives and a consideration of context as situated practice.Originality/valueThis is an original research study conducted as part of a PhD qualification which has contributed to further the understanding of workplace IL.
Engineering an image‐browsing environment: re‐purposing existing denotative descriptors
Authors: Yoon JungWon , O'Connor Brian 
Published: September 2010

PurposeThe paper provides a theory base for deriving connotative descriptors for photographs from existing denotative descriptors, and then demonstrates a model for enhancing browsing within image collections by providing a tool for carving up the searching space.Design/methodology/approachThe paper conceptually explores the nature of iconic messages contained in an image by adopting semiotics as a theoretical tool. A problem of image retrieval is identified as loss of connotative messages during the image representation process. The paper proposes an image‐retrieval model utilizing an association thesaurus that facilitates the assignment of connotative index terms by making use of denotative index terms of an image. A series of experiments are performed for evaluating the effectiveness of the proposed model.FindingsExperimental results demonstrate that the association thesaurus improves image‐retrieval effectiveness by increasing the recall of connotatively related image documents as well as the recall of browsing sets.Practical implicationsApplying connotative index terms to an image would be time consuming. Deriving connotative terms from denotative terms and then using them to enrich the browsing environment suggest a method of increasing retrieval effectiveness while reducing the resources required for representation.Originality/valueSince images are often used to illustrate concepts that are not immediately evident from just the objects in front of the lens, connotative descriptions are particularly valuable. Since human perception of images is, in a sense, hard wired into our brains, browsing is a frequent and reasonable search method in image collections. Using connotative descriptors to point the way to clusters of images with a higher probability of relevance changes thelocusof control over representation establishes an environment for dynamic representation, and gives credibility to browsing as a significant search method.
The determinants of overeducation: different measures, different outcomes?
Authors: Verhaest Dieter , Omey Eddy 
Published: September 2010

PurposeThe purpose of this paper is to assess the measurement sensitivity of the estimated determinants of overeducation.Design/methodology/approachThe paper analyses the determinants of overeducation among Flemish school leavers in their first job by means of probit regression analysis. Overeducation is measured on the basis of job analysis (JA), self‐assessments and realised matches.FindingsThe results demonstrate that the application of different overeducation measures sometimes leads to different outcomes. Only a few variables – for instance the student's academic grade in the final year – are consistently found to be important for the explanation of overeducation. Some outcomes are consistent with the supposition that several indicators actually measure other concepts.Research limitations/implicationsFurther research using JA measures that are based on alternative and more recent occupational classifications would be useful.Originality/valueThe application of different measures provides further insight into the overeducation measurement problem.
Fringe benefits and job satisfaction
Authors: Artz Benjamin 
Published: September 2010

PurposeThe paper seeks to empirically identify the theoretically ambiguous relationship between employer fringe benefit provision and worker job satisfaction.Design/methodology/approachUsing the five most recent waves of the National Longitudinal Survey of Youth, both pooled cross‐section and fixed effects estimates explain the relationship between fringe benefits and job satisfaction. The potential endogenous relationship is also tested using a recursive bivariate probit procedure.FindingsFringe benefits are significant and positive determinants of job satisfaction. The potential endogeneity between fringe benefits and job satisfaction is not shown in this dataset while controlling for fixed effects does not remove the significant impact of fringe benefits.Research limitations/implicationsA limitation is the inability to control for total compensation within the estimations and control for wage changes as a result of fringe benefit provision.Practical implicationsHigher levels of worker job satisfaction, potentially resulting from fringe benefit provisions, have been linked to important productivity measures such as lower quit rates and absenteeism.Originality/valueThe paper is the first to study the relationship between fringe benefits and job satisfaction in detail while additionally testing for the endogeneity of the relationship and controlling for fixed effects.