bluuebunny/crossref_metadata_2025_split huggingface dataset:
Aggressive high-grade NF2 mutant meningiomas downregulate oncogenic YAP signaling via the upregulation of VGLL4 and FAT3/4
Authors: Parrish Abigail G , Arora Sonali , Thirimanne H. Nayanga , Rudoy Dmytro , Schmid Sebastian , Sievers Philipp , Sahm Felix , Holland Eric C , Szulzewsky Frank 
Published: May 2024

AbstractMeningiomas are the most common primary brain tumors in adults. Although generally benign, a subset of meningiomas is of higher grade, shows aggressive growth behavior and recurs even after multiple surgeries. Around half of all meningiomas harbor inactivating mutations in NF2. While benign low-grade NF2 mutant meningiomas exhibit few genetic events in addition to NF2 inactivation, aggressive high-grade NF2 mutant meningiomas frequently harbor a highly aberrant genome. We and others have previously shown that NF2 inactivation leads to YAP1 activation and that YAP1 acts as the pivotal oncogenic driver in benign NF2 mutant meningiomas. Using bulk and single-cell RNA-Seq data from a large cohort of human meningiomas, we show that aggressive NF2 mutant meningiomas harbor decreased levels YAP1 activity compared to their benign counterparts. Decreased expression levels of YAP target genes are significantly associated with an increased risk of recurrence. We then identify the increased expression of the YAP1 competitor VGLL4 as well as the YAP1 upstream regulators FAT3/4 as a potential mechanism for the downregulation of YAP activity in aggressive NF2 mutant meningiomas. High expression of these genes is significantly associated with an increased risk of recurrence. In vitro, overexpression of VGLL4 resulted in the downregulation of YAP activity in benign NF2 mutant meningioma cells, confirming the direct link between VGLL4 expression and decreased levels of YAP activity observed in aggressive NF2 mutant meningiomas. Our results shed new insight on the biology of benign and aggressive NF2 mutant meningiomas and may have important implications for the efficacy of therapies targeting oncogenic YAP1 activity in NF2 mutant meningiomas.
PEX14 functions as a molecular link between optineurin and pexophagy in human cells
Authors: Li Hongli , Chen Suyuan , Lismont Celien , Vandewinkel Bram , Hussein Mohamed A. F. , Costa Cláudio F. , Imberechts Dorien , Liu Yiyang , Azevedo Jorge E , Vandenberghe Wim , Verhelst Steven , Baes Myriam , Fransen Marc 
Published: May 2024

AbstractPexophagy, the selective degradation of peroxisomes, is essential for removing excess or dysfunctional peroxisomes, and its dysregulation is linked to various diseases. Previous research has shown that optineurin (OPTN), an autophagy receptor involved in mitophagy, aggrephagy, and xenophagy, can induce pexophagy in HEK-293 cells. However, the underlying mechanism remains unclear. In this study, we used proximity labeling to identify PEX14, a peroxisomal membrane protein, as a neighboring partner of OPTN. Biochemical analyses revealed that PEX14 and OPTN interact through their respective coiled-coil and ubiquitin-binding domains. Further analyses demonstrated that the C-terminal half of overexpressed OPTN triggers pexophagy, likely by forming oligomers with endogenous OPTN. The co-localization of PEX14-OPTN complexes with LC3, combined with the suppression of OPTN-mediated peroxisome degradation by bafilomycin A1, supports a model in which PEX14 acts as a docking site for OPTN on the peroxisomal membrane, enabling the recruitment of the autophagic machinery for OPTN-mediated pexophagy.SummaryThis study uncovers and defines the peroxisomal membrane protein PEX14 as a key player in optineurin-driven pexophagy, advancing our mechanistic understanding of this cellular process. These findings open new avenues for developing therapeutic strategies targeting diseases associated with defective pexophagy.
Charging forward: unveiling the dynamics of consumer EV adoption in Asia's transition to green mobility
Authors: Han Chien-Shan , Hsu Yu-Ming , Hsu Han-Jen 
Published: May 2024

PurposeThis study aims to explore the determinants influencing consumer purchase intentions towards electric vehicles (EVs) within the Asian market. It specifically examines how perceived value and perceived risk interact with the moderating effects of environmental, policy, and social factors to shape consumer behaviors towards EV adoption. The purpose is to delineate the intricate mechanisms driving consumer intentions in the context of sustainable mobility solutions.Design/methodology/approachAdopting a quantitative research design, this investigation collected data via a survey targeting consumers across various Asian countries. The study utilized Structural Equation Modeling (SEM) to analyze the responses, enabling a robust examination of the relationships between perceived value, perceived risk, and the potential moderating roles of external factors on consumer purchase intentions towards EVs.FindingsThe analysis revealed that both perceived value and perceived risk significantly influence consumers' intentions to purchase EVs. It was also found that environmental factors effectively moderate the relationship between perceived risk and purchase intentions, while social factors moderate the relationship between perceived risk and purchase intentions, highlighting the complex influence of external elements on consumer decisions. Contrarily, policy factors did not exhibit a significant moderating impact on the relationships examined.Originality/valueThis research enriches the domain of sustainable technology adoption by providing nuanced insights into the factors driving consumer intentions towards EVs in the Asian context. It underscores the critical roles of perceived value and risk, along with the distinct moderating effects of environmental and social factors, offering strategic implications for stakeholders within the EV ecosystem. The study's findings contribute to the broader discourse on consumer behavior in green technology adoption, laying groundwork for future investigations across diverse settings.
Artificial intelligence schemes to predict the mechanical performance of lignocellulosic fibers with unseen data to enhance the reliability of biocomposites
Authors: Al-Jarrah Rami , AL-Oqla Faris M. 
Published: May 2024

PurposeThis work introduces an integrated artificial intelligence schemes to enhance accurately predicting the mechanical properties of cellulosic fibers towards boosting their reliability for more sustainable industries.Design/methodology/approachFuzzy clustering and stacked method approach were utilized to predict the mechanical performance of the fibers. A reference dataset contains comprehensive information regarding mechanical behavior of the lignocellulosic fibers was compiled from previous experimental investigations on mechanical properties for eight different fiber materials. Data encompass three key factors: Density of 0.9–1.6 g/cm3, Diameter of 5.9–1,000 µm, and Microfibrillar angle of 2–49 deg were utilized. Initially, fuzzy clustering technique was utilized for the data. For validating proposed model, ultimate tensile strength and elongation at break were predicted and then examined against unseen new data that had not been used during model development.FindingsThe output results demonstrated remarkably accurate and highly acceptable predictions results. The error analysis for the proposed method was discussed by using statistical criteria. The stacked model proved to be effective in significantly reducing level of uncertainty in predicting the mechanical properties, thereby enhancing model’s reliability and precision. The study demonstrates the robustness and efficacy of the stacked method in accurately estimating mechanical properties of lignocellulosic fibers, making it a valuable tool for material scientists and engineers in various applications.Originality/valueCellulosic fibers are essential for biomaterials to enhance developing green sustainable bio-products. However, such fibers have diverse characteristics according to their types, chemical composition and structure causing inconsistent mechanical performance. This work introduces an integrated artificial intelligence schemes to enhance accurately predicting the mechanical properties of cellulosic fibers towards boosting their reliability for more sustainable industries. Fuzzy clustering and stacked method approach were utilized to predict the mechanical performance of the fibers.
Beyond the Griliches biases
Authors: Andini Corrado , Andini Monica 
Published: May 2024

PurposeThe paper investigates the determinants of the Ordinary Least Squares (OLS) bias of the wage return to graduate education for high-school workers in Portugal.Design/methodology/approachThe study uses matched employer-employee data for Portugal, over the 2002–2012 period, to estimate a wage-schooling model that controls not only for individual observed characteristics, firm observed characteristics and year fixed effects, but also for three high-dimensional vectors of fixed effects – one for employees, one for employers and one for job titles.FindingsThe main results are the following. First, disregarding individual fixed effects is highly problematic, accounting for 48.5% of the OLS bias. Second, disregarding firm fixed effects is also problematic, accounting for 12.3% of the OLS bias.Research limitations/implicationsThe implication for the studies in the labor-supply literature that estimate, by means of instrumental variables, the wage returns to in-school work or to on-the-job schooling is that an instrument dealing with employee’s unobserved ability only may fail to meet the exclusion restriction.Practical implicationsTake the typical instrument based on a policy reform that changes the compulsory schooling level in the population. This instrument may well be argued to be correlated with the education of the employee and uncorrelated with the unobserved ability of the employee, but unfortunately it cannot be seen as orthogonal to the unobserved ability of the employer because of its correlation with the (unobserved) education of the manager. This is a simple corollary of the fact that the employee and the manager belong, in general, to the same population.Social implicationsIndividuals invest a considerable amount of resources in education, which is seen to have positive effects on several dimensions of individual life. Yet, the estimation of these effects is still surrounded by technical difficulties.Originality/valueTo the best of the authors’ knowledge, this is the first study that uses the Gelbach decomposition to investigate the determinants of the OLS bias of the wage return to graduate education for high-school workers.
Does crude oil price volatility affect risk-taking capability in business group firms: evidence from India?
Authors: Tripathi Nitya Nand , Tiwari Aviral Kumar , Hammoudeh Shawkat , Kumar Abhay 
Published: May 2024

PurposeThe study tests risk-taking and risk-aversion capabilities while distinguishing between business group firms and stand-alone firms and considering oil price volatility. Second, this attempt to study the linkage between risk-taking during market down movements and when the firms have established themselves as product market leaders. Third, this study analyses the “sentiment” state, where it explores the reaction of corporations when the market is in the negative direction, and lastly, it explores the linkage between product market competition and risk-aversion.Design/methodology/approachThis study uses financial information for 1,273 non-financial companies and other required data from various sources. The study employs panel data and utilizes different empirical methodologies, including the generalized method of moments (GMM) estimator, to test the stated hypotheses.FindingsWe find that the business group firms have more risk-taking proficiencies compared with the stand-alone firms. Moreover, this study discovers that the corporates avoid taking risks when the market is not performing well. Also, when the market is down and crude prices are high, the management expects high earnings in the future, willingly takes risks and shows that product market leaders do not follow the risk-aversion strategy.Practical implicationsThe empirical results indicate that oil price movement can restrict management’s behaviour when choosing a risky investment project. Management should develop a robust policy that follows the group of firms. In the policy, the management should describe the level of risk that may be taken by the firm and implement it when required.Originality/valueSince we do not find any studies in this context, then there is a major and essential gap in the literature that this study should fill.
Fluid workforce management in the health sector: navigating the changing face of workforces and their management
Authors: Samaan Daniel , Tursunbayeva Aizhan 
Published: May 2024

PurposeThis paper demystifies the fluid workforce phenomenon increasingly discussed in the circles of organizational innovators and explores the characteristic aspects of the fluid workforce in the healthcare sector.Design/methodology/approachWe analyze the concept and provide a generic review of definitions of a fluid workforce in relation to other similar concepts established in the academic and practitioner literature, contextualize the fluid workforce phenomenon in healthcare and distinguish relevant drivers and categories of fluid workers in this sector. We also discuss the implications of a fluid workforce for healthcare organizations, drawing on the health labor market and human resource management (HRM) practices frameworks.FindingsThe fluid workforce in healthcare is not new. Today’s main novelties are related to the wide diversity of types of fluid workforce that have emerged, the expanding scale of diffusion of the fluid workforce and the emergence of digital technologies to support HRM decisions. While a fluid workforce may provide solutions to address mismatches in the supply and demand of health workers, it can also worsen working conditions, increase dual practice and have implications for existing HRM practices.Originality/valueWe disentangle a novel term for the public sector, healthcare and HRM literature. We discern similarities and distinctions, presenting a framework for managing and analyzing this workforce at organizational and labor market levels in the healthcare sector. Acknowledging the challenges in estimating the existing fluid workforce labor market size, we offer practical methodologies to empirically estimate its prevalence within the healthcare industry and build an agenda for future research.
Delivering a culture change in property guardianship: recommendations for reform to the regulatory landscape
Authors: Bevan Chris 
Published: May 2024

Purpose
Property guardianship is increasingly being viewed as an alternative and, in many cases, a last resort to the unaffordable private rental market. This upsurge in the incidence of guardianship necessarily amplifies the existing legal grey areas and the inherent insecurity and precarity in the sector for guardians. Drawing on interviews with property guardians and archival research, the purpose of this study is to explore the background to the guardianship occupation model; highlight the key problems guardianship generates and, building on this, propose recommendations for reform to the regulatory landscape of guardianship. This study argues that a culture change in property guardianship is needed so that guardians can be better protected, and local authorities empowered to be more proactive in overseeing standards of guardian properties in their areas.

Design/methodology/approach
This study draws on qualitative semi-structured interviews with 46 property guardians and archival research.

Findings
The author argues that property guardians routinely enter the sector largely as a matter of last resort based on financial considerations or following difficult life experiences. Insecure and precarious, guardianship operates under licence agreements which provide less protection for guardians. Coupled with ambiguity around the application of existing housing legislation to guardianship and research showing non-engagement by local authorities with guardianship, this study suggests regulatory reform is urgently needed.

Originality/value
With traditional residential tenancies in the private rental sector increasingly unaffordable for many and guardianship becoming a viable alternative, this study argues for significant regulatory reform to the guardianship sector to ensure guardians are adequately protected under the law. This study presents a series of proposals to deliver a culture change in the sector.
A sustainability assessment modeling-based external account of the impacts of mining activities in Brazil
Authors: Angotii Marcello , Ferreira Aracéli Cristina de S. , Eugénio Teresa , Branco Manuel , Queiroz Juliana Molina 
Published: May 2024

Purpose
This study aims to propose and apply a sustainability assessment model (SAM) for the mineral extraction industry developed on the basis of elements of dialogic accounting.

Design/methodology/approach
Distinct from other similar exercises, ours is also one in external accounting that focuses on a set of mining companies operating in a specific geographical location. It was undertaken based on different perspectives from various stakeholders, including mining workers and city dwellers, retrospectively, using publicly available information, entirely independently of the set of companies regarding which impacts the authors try to offer an account and without their approval. Twenty indicators were identified from the perspective of value for society.

Findings
The results for all environmental externalities appeared to be negative, as companies’ attitudes continue to be reactive and on the threshold of legal requirements. This assessment of the selected social indicators emphasizes that accelerated expansion of mining activities poses a threat to the mining area in the long term, as it reduces the useful lives of mineral deposits and expands social and environmental externalities.

Practical implications
The authors propose to expand the horizon of accounting through a framework that combines elements of the SAM technology, dialogic accounting and external accounting. This investigation contributes to the development of social and environmental accounting practices through the discussion, proposal and use of an SAM, built with the cooperation of several social actors and from the perspective of the other rather than the entity.

Social implications
The authors tried to show how an SAM approach can be used in combination with dialogic accounting processes, increasing the accountability and awareness of the different groups of stakeholders, focusing on marginalized stakeholders, to offer an external account of the impacts of a set of companies from the mining sector operating in a specific geographical area.

Originality/value
This study’s findings suggest there are opportunities for accountants to support social and environmental accounting, thereby contributing to community awareness and empowering transformative action.
Treatment of giant neurofibromas in extremities and trunk wall of neurofibromatosis type 1 patients: a Chinese 12‐year single‐institution experience
Authors: Gao Qianqian , Yang Zhe , Ma Ning , Chen Sen , Li Yangqun 
Published: May 2024

AbstractBackgroundsGiant neurofibromas occurring in individuals diagnosed with neurofibromatosis type 1 (NF1) often result in considerable disfigurement, functional impairment, and diminished quality of life. Although debulking surgery poses inherent risks of complications, it remains the most efficacious approach to address these issues. The primary objective of this study was to share our surgical experience with giant neurofibromas in the extremities and trunk wall of NF1 patients which may help surgeons to minimize intraoperative bleeding and facilitate tumor excision.MethodsA retrospective review was conducted at a single center, encompassing 36 NF1 patients with giant neurofibromas in the extremities and trunk wall who underwent debulking surgery from July 2010 to July 2022.ResultsTwenty‐one male and fifteen female NF1 patients who received one to four surgical interventions were evaluated. The average age at the time of surgery was 17.8 years. The median follow‐up time was 52 months. Our findings revealed relatively low rates of complications and recurrence. Notably, patients expressed satisfaction with both the aesthetic and functional results.ConclusionsDebulking surgery of giant neurofibromas in the extremities and trunk wall of NF1 patients can effectively reduce the tumor burden, leading to improvements in both the appearance and function.
Branding the ‘VBA’ (Village Basketball Association) to revitalise a Miao village: Platform ruralism in the making
Authors: Zhang Han , Qian Junxi 
Published: May 2024

AbstractIn recent years, short‐video platforms represented by Douyin (TikTok) and Kuaishou (Kwai) have expanded to rural China. The rural, as an emerging ‘sunken market’ for digital platforms to generate revenue, has become an uncharted terrain for digital platforms to compete for, particularly in the context of the state's rural revitalisation strategy. Yao Shunwei, an independent photographer, uploaded a short video on Douyin in July 2022, recording a village basketball game in a Miao village (Taipan Village) in Guizhou to celebrate the Chixin Festival. The game quickly gained phenomenal popularity on digital platforms and was branded as ‘VBA’ (Village BA, appropriating the term NBA), contributing significantly to the revitalisation of the village. So far, work on rural places in their entanglement with digital platforms remains limited, lopsided on the rhetoric of a digital divide between the urban and the rural. Proposing the tentative concept of platform ruralism, this study probes into the emergent rural subjectivities and agencies vis‐à‐vis the negotiation, adaptation, innovation and autonomy of rural economies, livelihoods and socio‐cultural practices as they are imbricated by digital technologies and platforms. As such, it looks at how digital platforms have rescaled rural basketball activities and turned them into a nationally influential brand to enhance the wellbeing, social cohesion and cultural identity of rural communities. The branding of ‘VBA’ demonstrates how the rural can take on an active and resilient role in the rise of digital platforms.
Effects of replacing corn silage and soybean meal with an increasing percentage of fresh herbage on dairy cow nitrogen use efficiency and flows
Authors: Ferreira Manon , Delagarde Rémy , Edouard Nadège 
Published: May 2024

AbstractTo improve sustainability, dairy farms can reduce protein‐rich concentrate in the cows' diet providing fresh herbage produced on‐farm. This study aimed to quantify effects of increasing the percentage of fresh herbage (0%, 25%, 50%, and 75%, on a dry matter [DM] basis) in a partial mixed ration‐based diet on cow N use efficiency and excretion. The study was performed with five lactating cows, in a 4 × 4 Latin square design for four 3 week periods. Individual DM intake, milk yield, feces and urine excretions, and their N concentrations were measured daily. Dietary crude protein concentrations varied little among treatments (127 to 134 g/kg DM). DM intake and milk yield decreased linearly by 5.2 and 3.7 kg/day, respectively, while N use efficiency increased by 4.1 percentage points from 0% to 75% DM of fresh herbage in the diet. Urinary N was not influenced by the treatments, while fecal N decreased as the percentage of fresh herbage increased. This study highlights that replacing partial mixed ration with an increasing percentage of fresh herbage with slight changes in dietary N concentration increases N use efficiency and the percentage of urinary N in excreted N.