bluuebunny/crossref_metadata_2025_split huggingface dataset:
Review Article: Periodontal disease and pre‐eclampsia: a systematic review
Authors: Kunnen Alina , Van Doormaal Jasper J. , Abbas Frank , Aarnoudse Jan G. , Van Pampus Maria G. , Faas Marijke M. 
Published: November 2010

Kunnen A, van Doormaal JJ, Abbas F, Aarnoudse JG, van Pampus MG, Faas MM. Periodontal disease and pre‐eclampsia: a systematic review. J Clin Periodontol 2010; 37: 1075–1087. doi: 10.1111/j.1600‐051X.2010.01636.xAbstractAim: This review evaluates the possible relationship between periodontal disease and pre‐eclampsia, a major pregnancy complication. A generalized inflammatory response plays an important role in the pathogenesis of pre‐eclampsia. Because periodontal disease is a low‐grade inflammatory state, periodontal disease might contribute to the pathogenesis of pre‐eclampsia.Main Findings and Conclusion: A literature search of PubMed, EMBASE and CINAHL until August 2010 revealed 12 eligible observational studies and three randomized‐controlled trials (RCTs). It appeared difficult to compare these studies, due to variations in definitions of periodontal disease and pre‐eclampsia, timing of periodontal examination and inadequate control for confounding factors. Eight observational studies reported a positive association, while four studies found no association. None of the RTCs reported reductions in pre‐eclamptic rate after periodontal therapy during pregnancy. Therefore, it is questionable whether periodontal disease plays a causal role in the pathogenesis of pre‐eclampsia. The observed association in eight observational studies might be the result of induction of periodontal disease due to the pre‐eclamptic state or it may be an epiphenomenon of an exaggerated inflammatory response to pregnancy. Larger RCTs with pre‐eclampsia as the primary outcome and pathophysiological studies are required to explore causality and to dissect biological mechanisms involved.
Heptanol triggers cardioprotection via mitochondrial mechanisms and mitochondrial potassium channel opening in rat hearts
Authors: Johansen D. , Sanden E. , Hagve M. , Chu X. , Sundset R. , Ytrehus K. 
Published: November 2010

AbstractAim:  To investigate mechanisms behind heptanol (Hp)‐induced infarct size reduction and in particular if protection by pre‐treatment with Hp is triggered through mitochondrial mechanisms.Methods:  Langendorff perfused rat hearts, isolated mitochondria and isolated myocytes were used. Infarct size, mitochondrial respiration, time to mitochondrial permeability transition pore (MPTP) opening and AKT and glycogen synthase kinase 3 beta (GSK‐3β) phosphorylation were examined.Results:  Pre‐treatment with Hp reduced infarct size from 29.7 ± 3.4% to 12.6 ± 2.1%. Mitochondrial potassium channel blockers 5‐hydroxy decanoic acid (5HD) blocking mitoKATP and paxilline (PAX) blocking mitoKCa abolished cardioprotective effect of Hp (Hp + 5HD 36.7 ± 2.9% and Hp + PAX 40.2 ± 2.8%). Hp significantly reduced respiratory control ratio in both subsarcolemmal and interfibrillar mitochondria in a dose‐dependent manner (0.5–5.0 mm). The ADP oxygen ratio was also significantly reduced by Hp (2 mm). Laser scanning confocal microscopy of tetramethylrhodamine‐loaded isolated rat myocytes using line scan mode showed that Hp increased time to MPTP opening. Western blot analysis showed that pre‐treatment with Hp increased phosphorylation of AKT and GSK‐3β before ischaemia and after 30 min of global ischaemia.Conclusion:  Pre‐treatment with Hp protects the heart against ischaemia‐reperfusion injury. This protection is most likely mediated via mitochondrial mechanisms which initiate a signalling cascade that converges on inhibition of opening of MPTP.
Caring for Creation and Striving for Climate Justice: Implications for mission and spirituality1
Authors: Kerber Guillermo 
Published: November 2010

AbstractPresenting climate change as one of the most important challenges the world faces today, and one that already affects populations in the Pacific, in Africa, in the Caribbean and in Southeast Asia, the author links spirituality and mission with the advocacy work being carried on by the World Council of Churches on climate change issues. The article asserts that the ecumenical work on climate change is rooted in a biblical imperative. Two biblical insights, the wholeness of creation and the commitment for justice, are unfolded as guidelines for the ecumenical concern on climate change. The first one requests a renewed theology of creation that responds adequately to the accusation that Christianity is anthropocentric. In this theology, the trinitarian understanding of creation and the role of the Holy Spirit are highlighted. Together with theology, ethics is a core contribution churches make to the climate change debate. This ethical approach is based on the commitment for justice, biblically rooted, which pays special attention to the poor, the vulnerable ones. Main principles of climate justice from the UN Framework Convention on Climate Change are also analyzed. Finally, the spiritual dimension is presented following texts of Leonardo Boff and Larry Rasmussen, among others, as a specific contribution Christian churches make to climate change, ecology and environmental issues.
Creation, Theological Imagination and Questions about Discipleship
Authors: Motte Mary 
Published: November 2010

AbstractScience yields factual data about the unfolding nature of the universe that challenges us profoundly and with urgency. This data verifies we are living in a dynamic world within a dynamic universe that is still in the process of creation. This process is wrought with risk and is also defined by relationships that emerge from the most basic elements of life. These times require a new cosmology. Haught reminds us that the adventurous narrative of love and liberation at work beneath the surface available to science is the work space of theologians. The patterns of relationships in all life forms evoke the image of the Trinity as a communion of relations. Discovering a new way of seeing requires doing theology in new ways and Delio notes this means a search for the newness of God evident in the New Testament. Ultimately, new ways of seeing require examining discipleship. Contemplation through the ages permits us to grasp that this Trinity of Love is our God who dwells with us. Our insight into God continually unfolds in history through the continuity of the Paschal Mystery of Christ in his incarnation, death and resurrection. Profound suffering, disaster and tragedy mark the age in which we live. Yet God is not absent. The call to discipleship with the One who has realized God's presence among us in the Paschal Mystery is a realization of a humility that is far removed from power, control and domination. We discover a humble God in the place of the poor because this is how God has become incarnate among us.
Interrogation, Interpretation and Integration of Spirituality: Insights from Sri Aurobindo for “Care for Creation”
Authors: Prince Brainerd 
Published: November 2010

AbstractThis paper brings together three strands of enquiry – interrogation of spirituality, interpretation of spirituality and Sri Aurobindo's integrative spirituality – which form the three natural parts of the paper. In the first part I interrogate the idea and category “spirituality” and argue that this term came to be understood in opposition to the “material” only in medieval times, and thus the common notion of spirituality as opposed to materiality is misplaced. In the second part, in light of George Lindbeck's work, I will explore the question – is it possible for different traditions that interpret spirituality differently to hold a common unifying position? I will argue that if we are to arrive at an understanding of spirituality that will be acceptable to different traditions, then the very conception of spirituality must be informed by all. In the final part, I will argue that Sri Aurobindo's integrative spirituality offers a sufficient rationale for creation‐care by proposing a view of spirituality which, on the one hand, overcomes the spiritual‐material dichotomy, while on the other, contains an implicit guard against imposing its view of spirituality on other traditions. Finally, by bringing Sri Aurobindo into the dialogue I demonstrate how insights from another tradition can be drawn to enrich our understanding of spirituality.
A practical method of design of concrete pedestals for columns for anchor rod tension breakout
Authors: Ashkinadze Konstantin 
Published: November 2010

This technical note considers concrete pedestals bearing steel and concrete columns attached to the foundation with cast-in anchor rods. One mechanism of pedestal failure — the anchor rod breakout in tension — is considered. Uplift and shear forces and bending moments in the base cause tension in the anchor rods. Classical methods of statics and finite element analysis (FEA) are applicable to establish the anchor likely to fail first. For the design of the anchor rod embedment in the concrete, the new “cone balancing” method is proposed. It considers equilibrium of the pullout cone of concrete, ascertained by development of vertical reinforcing bars into the pullout cone and below the failure plane. The method allows determination of tensile force in each individual rebar and direct checking of its size and development length.
hTERT Overexpression Alleviates Intracellular ROS Production, Improves Mitochondrial Function, and Inhibits ROS-Mediated Apoptosis in Cancer Cells
Authors: Indran Inthrani R. , Hande Manoor P. , Pervaiz Shazib 
Published: November 2010

AbstractThe human telomerase reverse transcriptase (hTERT) is the catalytic subunit of the telomerase holoenzyme. Evidence is accumulating to link hTERT to activities other than telomere maintenance and immortalization. Here, we show that hTERT overexpression not only reduces the basal cellular reactive oxygen species (ROS) levels but also inhibits endogenous ROS production in response to stimuli that induce intracellular ROS generation. Conversely, siRNA-mediated gene silencing of hTERT potentiated the increase in cellular ROS levels following exposure to oxidative stress. This antioxidant effect of hTERT is mediated via a significant increase in the ratio of reduced to oxidized glutathione (GSH:GSSG) as well as efficient recovery of the oxidized peroxiredoxin to its nonoxidized form. Our data also provide evidence for mitochondrial localization of hTERT, and a significantly higher activity of cytochrome C oxidase, the rate-limiting enzyme in the mitochondrial electron transport chain, in hTERT overexpressing cells. To ascertain whether the improved mitochondrial function and antioxidant effect of hTERT could provide cancer cells with a survival advantage, the effect of oxidative stress on mitochondrial apoptosis was evaluated. Indeed, hTERT overexpressing cells inhibited cytosolic acidification, translocation of Bax, the drop in mitochondrial transmembrane potential, the release of cytochrome C to the cytosol, and cell death. Taken together, these data demonstrate a hitherto undefined role of hTERT in alleviating cellular ROS levels by way of potentiating the cellular antioxidant defense systems, and in doing so endowing cancer cells with the ability to evade death stimuli. Cancer Res; 71(1); 266–76. ©2010 AACR.
Elevated Soluble fms-Like Tyrosine Kinase-1 Levels in Acute Coronary Occlusion
Authors: Kapur Navin K. , Heffernan Kevin S. , Yunis Adil A. , Nguyen Tuan A. , Aronovitz Mark J. , Parpos Peter , Wilson Szuhuei , Baker Corey K. , Esposito Michele L. , Shah Ameer , Kimmelstiel Carey D. , Weintraub Andrew , Karas Richard H. , Mendelsohn Michael E. 
Published: November 2010

Objective—
Early recognition of an acute coronary occlusion (ACO) improves clinical outcomes. Soluble fms-like tyrosine kinase-1 (sFLT1) is an endothelium-derived protein induced by hypoxia. We tested whether sFLT1 levels are elevated in ACO.

Methods and Results—

Serum sFLT1 levels were measured by enzyme-linked immunosorbent assay in patients with ST-segment elevations and angiographically confirmed ACO, unstable angina/non ST-segment elevation myocardial infarction, and 2 control groups. To further explore sFLT1 release, a mouse model of ACO and in vitro human coronary artery endothelial cell injury were used. sFLT1 levels were increased in ACO compared with unstable angina/non-ST-elevation myocardial infarction, catheterized controls, or healthy volunteers (200.7±15.5 versus 70.7±44.0 versus 10.2±4.0 versus 11.7±1.7 pg/mL respectively,
P
<0.001 versus ACO). At presentation, all ACO patients had elevated sFLT1 levels (>15 pg/mL, 99th percentile in controls), whereas 57% had levels of the MB isoform of creatine kinase levels >10 ng/mL (
P
<0.01) and 85% had ultrasensitive troponin I levels >0.05 ng/mL (
P
<0.05). Within 60 minutes after symptom onset, sFLT1 was more sensitive than the MB isoform of creatine kinase or ultrasensitive troponin I for ACO (100% versus 20% versus 20% respectively;
P
≤0.01 for each). Within 60 minutes of ACO in mice, sFLT1 levels were elevated. Hypoxia and thrombin increased sFLT1 levels within 15 minutes in human coronary artery endothelial cells.

Conclusion—
sFLT1 levels may be an early indicator of endothelial hypoxia in ACO.
Influence of Apolipoprotein A-I Domain Structure on Macrophage Reverse Cholesterol Transport in Mice
Authors: Alexander Eric T. , Vedhachalam Charulatha , Sankaranarayanan Sandhya , de la Llera-Moya Margarita , Rothblat George H. , Rader Daniel J. , Phillips Michael C. 
Published: November 2010

Objective—
The goal of this study was to determine the influence of apolipoprotein A-I (apoA-I) tertiary structure domain properties on the antiatherogenic properties of the protein. Two chimeric hybrids with the N-terminal domains swapped (human-mouse apoA-I and mouse-human apoA-I) were expressed in apoA-I-null mice with adeno-associated virus (AAV) and used to study macrophage reverse cholesterol transport (RCT) in vivo.

Methods and Results—

The different apoA-I variants were expressed in apoA-I-null mice that were injected with [H
3
]cholesterol-labeled J774 mouse macrophages to measure RCT. Significantly more cholesterol was removed from the macrophages and deposited in the feces via the RCT pathway in mice expressing mouse-H apoA-I compared with all other groups. Analysis of the individual components of the RCT pathway demonstrated that mouse-H apoA-I promoted ATP-binding cassette transporter A1–mediated cholesterol efflux more efficiently than all other variants, as well as increasing the rate of cholesterol uptake into liver cells.

Conclusion—
The structural domain properties of apoA-I affect the ability of the protein to mediate macrophage RCT. Replacement of the N-terminal helix bundle domain in the human apoA-I with the mouse apoA-I counterpart causes a gain of function with respect to macrophage RCT, suggesting that engineering some destabilization into the N-terminal helix bundle domain or increasing the hydrophobicity of the C-terminal domain of human apoA-I would enhance the antiatherogenic properties of the protein.
Influences of Aortic Motion and Curvature on Vessel Expansion in Murine Experimental Aneurysms
Authors: Goergen Craig J. , Azuma Junya , Barr Kyla N. , Magdefessel Lars , Kallop Dara Y. , Gogineni Alvin , Grewall Amarjeet , Weimer Robby M. , Connolly Andrew J. , Dalman Ronald L. , Taylor Charles A. , Tsao Philip S. , Greve Joan M. 
Published: November 2010

Objective—
To quantitatively compare aortic curvature and motion with resulting aneurysm location, direction of expansion, and pathophysiological features in experimental abdominal aortic aneurysms (AAAs).

Methods and Results—

MRI was performed at 4.7 T with the following parameters: (1) 3D acquisition for vessel geometry and (2) 2D cardiac-gated acquisition to quantify luminal motion. Male 24-week-old mice were imaged before and after AAA formation induced by angiotensin II (AngII)–filled osmotic pump implantation or infusion of elastase. AngII-induced AAAs formed near the location of maximum abdominal aortic curvature, and the leftward direction of expansion was correlated with the direction of suprarenal aortic motion. Elastase-induced AAAs formed in a region of low vessel curvature and had no repeatable direction of expansion. AngII significantly increased mean blood pressure (22.7 mm Hg,
P
<0.05), whereas both models showed a significant 2-fold decrease in aortic cyclic strain (
P
<0.05). Differences in patterns of elastin degradation and localization of fluorescent signal from protease-activated probes were also observed.

Conclusion—
The direction of AngII aneurysm expansion correlated with the direction of motion, medial elastin dissection, and adventitial remodeling. Anterior infrarenal aortic motion correlated with medial elastin degradation in elastase-induced aneurysms. Results from both models suggest a relationship between aneurysm pathological features and aortic geometry and motion.
A Possible Trace of Oresme’s Condicio-Theory of Accidents in an Anonymous Commentary on Aristotle’s Meteorology
Authors: Kirschner Stefan 
Published: November 2010

AbstractIn his commentary on Aristotle’s Physics, Nicole Oresme (c. 1320-1382) propounds a very specific theory of the ontological status of accidents. Characteristic of Oresme’s view on accidents is that he does not consider them accidental forms, but only so-called condiciones or modi of the substance. Unlike the term “modus”, the term “condicio” seems to be very characteristic of Oresme’s own terminology. Up to now it has been unknown whether Oresme exerted any influence with his condicio-theory of accidents. This paper presents an anonymous 14th-century commentary on Aristotle’s Meteorology (Munich, Bayerische Staatsbibliothek, Clm 4375, ff. 19r-46v), in two Questions of which the term “condicio” occurs in an ontological context. Moreover, the text shows further striking coincidences with known works by Oresme, and this makes an influence by Oresme appear all the more probable.
Knowing Lions and Understanding “Lion”: Two Jobs for Concepts in Ockham?
Authors: Schierbaum Sonja 
Published: November 2010

AbstractExternalist readings of Ockham are currently most prominent in the literature. For instance, an externalist interpretation with respect both to mental content and the meaning of expressions is advocated by prominent scholars. In this paper, I want to argue that although this externalist picture is certainly not incorrect, it is nonetheless incomplete. As I show, Ockham distinguishes between two ways of acquiring concepts: one of them can be accounted for in wholly externalist terms while the other involves the understanding of linguistic expressions. According to the reading of Ockham I suggest here, it turns out that we can have two kinds of concepts pertaining to the same kind of things. But only one of the two is completely determined by external relations. Thus I conclude that the externalist picture of Ockham calls for some additions.
Doing Theology in Public: An Engagement with Economic Rationalism
Authors: Darragh Neil 
Published: November 2010

AbstractThis article is concerned with the process by which the reflective Christian may go about doing theology in a way that contributes to public issues affecting society. The particular method adopted by a person who is both theologian and citizen will depend on the nature of the society and Christianity’s status within that society. The article is concerned primarily with the transparency of a theological method that can operate effectively in the context of a pluralist society where social consensus is at issue. It uses the engagement with economic rationalism as a way of illustrating how such engagement in public discourse can occur.
Public Theology and Music
Authors: Gill Robin 
Published: November 2010

AbstractThis article argues that music may be an effective but under-explored metaphor for public theology. Specifically music can act as a helpful metaphor for theologians seeking to respond to three dominant criticisms of public theology, namely: that theology is too particularistic to be relevant to public discourse; that theology (and religion more widely) is harmful and dangerous especially after 9/11; that theology offers nothing that is objective to public discourse. The article responds to these criticisms by pointing out that they can be applied to public music too, but that the world would be impoverished if music (and theology) were simply to be eliminated.
Edward Schillebeeckx and the Suffering Human Being
Authors: Bergin Helen 
Published: November 2010

AbstractThis article begins by examining the nature of being human and the nature of suffering within the writings of Belgian Catholic theologian, Edward Schillebeeckx. Particular focus is given to Schillebeeckx’s understanding of the humanum—the essence of the human being which challenges another human being to respond with respect. Schillebeeckx’s understandings of the humanum are then set alongside an event in nineteenth century Aotearoa New Zealand in which Maori were forcibly removed by governmental authorities from their land at Parihaka. I propose that Schillebeeckx’s theological understandings of the humanum are valuable in engaging with and interpreting this historical event. Ultimately, I argue that Schillebeeckx’s interpretations of suffering and of being human offer fruitful insights for public theology.
Reinhold Niebuhr and the Ethics of Christian Realism
Authors: Marsden John 
Published: November 2010

AbstractAfter considering the social and pastoral context in which Niebuhr began to develop his theology, some of the leading influences and dominant themes are identified. Through engaging with a gritty Marxian class analysis Niebuhr launched his attack upon the social idealism of so much of the Christian witness of his generation. In mid-life the critique of liberalism and his ‘Christian realism’ are informed by a wrestling with the Augustinian and Reformation traditions. Later still Christian realism gives way to a more pragmatic chastened liberalism. The dualism between the personal and social, which characterized Niebuhr’s ethics throughout his life, is critiqued and seen as part of a general pessimism that betrays the degree to which he remained marked by the Lutheran tradition.
‘If you are saved you cannot forget your parents’: Agency, Power, and Social Repositioning in Tanzanian born-again Christianity
Authors: Lindhardt Martin 
Published: November 2010

AbstractIn much of the literature on African Pentecostalism, conversion has been associated with a striving for modernist individualist identities and a strategy for legitimising social, generational rupture. This article contributes to the existing scholarly field by shedding light on the ways in which urban Tanzanian born-again Christians address generational antagonisms and position themselves in relation to elder generations. Drawing on anthropological discussions of the concept of agency and focusing particular attention on the ways in which a specific kind of agency is cultivated through participation in ritual, I argue against a narrow association of born-again Christianity with modernist individualism. While an assertion of individual autonomy is implied in conversion, Tanzanian born-again Christians do not cease to be social beings, deeply embedded in family relationships. I demonstrate how born-again religious practice enables urban Tanzanians to actively rephrase and sometimes even improve their relationships with unconverted family elders.
Versdubletten Zu Prudentius, Peristephanon 2,514
Authors: Gnilka Christian 
Published: November 2010

AbstractThe line Prud. perist. 2,514 caused the interpolation of two spurious lines, each of which was made to substitute the authentic one, which itself was considered difficult or obscure. Such traces of the rimaneggiamento of the genuine text, proven by the manuscripts, should not be neglected by the editors since they bear witness to the widespread alteration of the text, often not attested by the documents, and to the existence of a critical edition in late antiquity.