bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of Ketogenic Diet on Gastroesophageal Reflux Disease: Literature Review and Exploratory Study
Authors: Latorre-Rodríguez Andrés R. , Munir Seema , Mittal Sumeet K. 
Published: May 2024

Background: Management strategies for gastroesophageal reflux disease (GERD) include lifestyle changes, medications, and surgery. A very low carbohydrate diet (VLCD) may offer an effective treatment option. Thus, we aimed to evaluate the effects of a VLCD on GERD through a literature review and exploratory study. Methods: We performed a literature search using MeSH and free-text terms in MEDLINE, EMBASE, Cochrane, and Google Scholar to summarize the available evidence through March 2023. Furthermore, we conducted an exploratory study in patients with GERD and a BMI > 25 kg/m2 without prior antireflux surgery. The subjects followed a strict VLCD guided by a medical bariatrician for 4 weeks and completed periodical medical and laboratory evaluations. Descriptive and inferential statistics were applied to assess the covariates before and after intervention. Significance level (α) was set at .05. Results: We found 5 studies reporting the effects of a VLCD on GERD. All of them reported relief of GERD-related symptoms and a decrease in distal acid exposure time (AET) in the short term (6 days to 16 weeks) in most subjects. In our exploratory study, a VLCD reduced the mean BMI (32.2 ± 2.75 vs 30.4 ± 2.23 kg/m2, P = .022) and AET (10.8 ± 3.7 vs 5.5 ± 4.2%, P = .049) among the cohort. Moreover, the DeMeester score and number of proximal reflux episodes improved in 3 patients, and the GERD-Health Related Quality of Life score improved in all 4. Conclusions: Current evidence, including our exploratory study, suggests that a VLCD in overweight or obese patients with GERD may have significant immediate benefits. Further studies are warranted.
A comprehensive analysis of patients with cerebral arteriovenous malformation with headache: assessment of risk factors and treatment effectiveness
Authors: Zhang Haibin , Han Heze , Ma Li , Li Ruinan , Li Zhipeng , Li Anqi , Yuan Kexin , Zhu Qinghui , Wang Chengzhuo , Zhang Yukun , Zhang Hongwei , Gao Dezhi , Guo Geng , Kang Shuai , Ye Xun , Li Youxiang , Sun Shibin , Wang Hao , Hao Qiang , Chen Yu , Wang Rong , Chen Xiaolin , Zhao Yuanli ,   Registry of Multimodality Treatment for Brain Arteriovenous Malformation in Mainland China (MATCH)
Published: May 2024

Abstract
Background
Due to the high mortality and disability rate of intracranial hemorrhage, headache is not the main focus of research on cerebral arteriovenous malformation (AVM), so research on headaches in AVM is still scarce, and the clinical understanding is shallow. This study aims to delineate the risk factors associated with headaches in AVM and to compare the effectiveness of various intervention treatments versus conservative treatment in alleviating headache symptoms.

Methods
This study conducted a retrospective analysis of AVMs who were treated in our institution from August 2011 to December 2021. Multivariable logistic regression analysis was employed to assess the risk factors for headaches in AVMs with unruptured, non-epileptic. Additionally, the effectiveness of different intervention treatments compared to conservative management in alleviating headaches was evaluated through propensity score matching (PSM).

Results
A total of 946 patients were included in the analysis of risk factors for headaches. Multivariate logistic regression analysis identified that female (OR 1.532, 95% CI 1.173–2.001, p = 0.002), supply artery dilatation (OR 1.423, 95% CI 1.082–1.872, p = 0.012), and occipital lobe (OR 1.785, 95% CI 1.307–2.439, p < 0.001) as independent risk factors for the occurrence of headaches. There were 443 AVMs with headache symptoms. After propensity score matching, the microsurgery group (OR 7.27, 95% CI 2.82–18.7 p < 0.001), stereotactic radiosurgery group(OR 9.46, 95% CI 2.26–39.6, p = 0.002), and multimodality treatment group (OR 8.34 95% CI 2.87–24.3, p < 0.001) demonstrate significant headache relief compared to the conservative group. However, there was no significant difference between the embolization group (OR 2.24 95% CI 0.88–5.69, p = 0.091) and the conservative group.

Conclusions
This study identified potential risk factors for headaches in AVMs and found that microsurgery, stereotactic radiosurgery, and multimodal therapy had significant benefits in headache relief compared to conservative treatment. These findings provide important guidance for clinicians when developing treatment options that can help improve overall treatment outcomes and quality of life for patients.
An interdisciplinary integrated specialized one-stop outpatient clinic for idiopathic intracranial hypertension – an assessment of sick leave, presenteeism, and health care utilization
Authors: Bsteh Gabriel , Macher Stefan , Krajnc Nik , Marik Wolfgang , Michl Martin , Müller Nina , Zaic Sina , Harreiter Jürgen , Novak Klaus , Wöber Christian , Pemp Berthold 
Published: May 2024

Abstract
Background
Management of idiopathic intracranial hypertension (IIH) is complex requiring contributions from multiple specialized disciplines. In practice, this creates considerable organizational and communicational challenges. To meet those challenges, we established an interdisciplinary integrated outpatient clinic for IIH with a central coordination and a one-stop- concept. Here, we aimed to evaluate effects of this concept on sick leave, presenteeism, and health care utilization.

Methods
In a retrospective cohort study, we compared the one-stop era with integrated care (IC, 1-JUL-2021 to 31-DEC-2022) to a reference group receiving standard care (SC, 1-JUL-2018 to 31-DEC-2019) regarding economic outcome parameters assessed over 6 months. Multivariate binary logistic regression models were used to adjust for confounders.

Results
Baseline characteristics of the IC group (n = 85) and SC group (n = 81) were comparable (female: 90.6% vs. 90.1%; mean age: 33.6 vs. 32.8 years, educational level: ≥9 years of education 60.0% vs. 59.3%; located in Vienna 75.3% vs. 76.5%). Compared to SC, the IC group showed significantly fewer days with sick leave or presenteeism (-5 days/month), fewer unscheduled contacts for IIH-specific problems (-2.3/month), and fewer physician or hospital contacts in general (-4.1 contacts/month). Subgroup analyses of patients with migration background and language barrier consistently indicated stronger effects of the IC concept in these groups.

Conclusions
Interdisciplinary integrated management significantly improves the burden of IIH in terms of sick leave, presenteeism and healthcare consultations – particularly in socioeconomically underprivileged patient groups.
Soil contamination in a cemetery area: a case study in Nova Hartz City—RS, Brazil
Authors: Morandi Leandra , de Borba Willian Fernando , da Ros Clóvis Orlando , da Silva Vanderlei Rodrigues , Toebe Marcos , Somavilla Lucindo , da Cunha Kemerich Pedro Daniel , Stahlhöfer Dienifer 
Published: May 2024

AbstractWe conducted a study in a cemetery area covering 2608.53 m2 in the municipality of Nova Hartz, Metropolitan Region of the State of Rio Grande do Sul. Soil samples were collected to determine the physicochemical parameters of the local soil at nine points within the study area and at three different depths (0 cm, 50 cm, and 120 cm). Granulometry and saturated hydraulic conductivity of the soil were assessed, and chemical analyses for Cadmium, Cobalt, Copper, and Chromium were performed using the Atomic Absorption Spectrometry technique.The results revealed that the soil exhibited average values of 78.34% sand, 8.25% silt, and 13.41% clay, classifying it as sandy loam. The saturated hydraulic conductivity was measured at 5.7 × 10–4 cm s−1 across the profile (from 0 to 120 cm). Chemical analyses identified concentrations exceeding the allowed limits for Cadmium (points 1, 4, 5, 6, 7, 8, and 9), Cobalt (points 2, 3, 4, 5, 7, and 8), and Copper (points 4, 5, 6, 7, and 8), with only two values for Chromium (both at point 7). Some points exhibited concentrations above the maximum allowed values at multiple depths. Evaluating vertical distribution, Cadmium did not show depth variations, suggesting a possible natural origin unrelated to cemetery activities. Conversely, Copper, Cobalt, and Chromium displayed increased concentrations with depth. In conclusion, significant changes in concentrations of Cadmium, Cobalt, and Copper were observed, especially between depths of 0 and 120 cm.
SmartWood: field-based analysis of large wood movement dynamics using inertial measurement units (IMUs)
Authors: Spreitzer Gabriel , Schalko Isabella , Boes Robert M. , Weitbrecht Volker 
Published: May 2024

AbstractWood plays an important ecological role in rivers. Yet challenges arise when large wood (LW) is mobilised and transported during floods. Due to a lack of quantitative data, movement behaviour of LW during floods is still not well understood to date. A proof-of-concept study was conducted at three Swiss rivers to test state-of-the-art sensor-tagged logs, so-called “SmartWood” and collect quantitative field-scale data about LW movement behaviour. The experiments utilised innovative inertial measurement units (IMUs), which have been developed at the Laboratory of Hydraulics, Hydrology and Glaciology (VAW) at ETH Zurich and implanted into wood logs (SmartWood) at prototype scale. Each IMU comprised three individual sensors (gyroscope, accelerometer, and magnetometer) and was equipped with an on-board processor, an AA battery (4.35 V), a memory (8 MB), and a Wi-Fi transmitter (100 m) for data transfer. After successful initial verification tests of the sensors, the IMUs were installed into debranched wood logs, measuring 4.35 m in length and 0.33 m in diameter. At the time of the field experiments, each SmartWood-log weighted between 170 and 220 kg, yielding a density of roughly 500 kg∙m−3. At the Limmat, Thur, and Grosse Melchaa Rivers in Switzerland, innovative yet discontinuous data were obtained. Results revealed consistent movement dynamics across all field sites. Specifically, we observed positive yaw movement during transport of SmartWood along the left river bank and negative yaw movement along the right river bank. Furthermore, interactions of SmartWood with channel boundaries, riparian vegetation, and objects (e.g., ferry dock) were registered and quantified, even when the SmartWood-log was transported out of sight of traditional sensing methods. The conducted field experiments enabled the initial testing of SmartWood in the field and exposed critical limitations of the IMUs and software algorithms for the reconstruction and analysis of floating LW dynamics. The gained knowledge and introduced sensing method will benefit the quantitative assessment of LW dynamics in rivers to maintain safety and functionality for instream structures (e.g., considering LW movement dynamics for the robust design of LW retention and guiding structures), but also river restoration projects and numerical models that rely on quantitative field-scale data.
Computer vision digitization of smartphone images of anesthesia paper health records from low-middle income countries
Authors: Folks Ryan D. , Naik Bhiken I. , Brown Donald E. , Durieux Marcel E. 
Published: May 2024

Abstract
Background
In low-middle income countries, healthcare providers primarily use paper health records for capturing data. Paper health records are utilized predominately due to the prohibitive cost of acquisition and maintenance of automated data capture devices and electronic medical records. Data recorded on paper health records is not easily accessible in a digital format to healthcare providers. The lack of real time accessible digital data limits healthcare providers, researchers, and quality improvement champions to leverage data to improve patient outcomes. In this project, we demonstrate the novel use of computer vision software to digitize handwritten intraoperative data elements from smartphone photographs of paper anesthesia charts from the University Teaching Hospital of Kigali. We specifically report our approach to digitize checkbox data, symbol-denoted systolic and diastolic blood pressure, and physiological data.

Methods
We implemented approaches for removing perspective distortions from smartphone photographs, removing shadows, and improving image readability through morphological operations. YOLOv8 models were used to deconstruct the anesthesia paper chart into specific data sections. Handwritten blood pressure symbols and physiological data were identified, and values were assigned using deep neural networks. Our work builds upon the contributions of previous research by improving upon their methods, updating the deep learning models to newer architectures, as well as consolidating them into a single piece of software.

Results
The model for extracting the sections of the anesthesia paper chart achieved an average box precision of 0.99, an average box recall of 0.99, and an mAP0.5-95 of 0.97. Our software digitizes checkbox data with greater than 99% accuracy and digitizes blood pressure data with a mean average error of 1.0 and 1.36 mmHg for systolic and diastolic blood pressure respectively. Overall accuracy for physiological data which includes oxygen saturation, inspired oxygen concentration and end tidal carbon dioxide concentration was 85.2%.

Conclusions
We demonstrate that under normal photography conditions we can digitize checkbox, blood pressure and physiological data to within human accuracy when provided legible handwriting. Our contributions provide improved access to digital data to healthcare practitioners in low-middle income countries.
Comparative transcriptome analysis between two different cadmium-accumulating genotypes of soybean (Glycine max) in response to cadmium stress
Authors: Liu Xiaoqing , Zhang Hongmei , Zhang Wei , Jia Qianru , Chen Xin , Chen Huatao 
Published: May 2024

Abstract
Background
Cadmium (Cd) is extremely toxic and non-essential for plants. Different soybean varieties differ greatly in their Cd accumulation ability, but little is known about the underlying molecular mechanisms.

Results
Here, we performed transcriptomic analysis using Illumina pair-end sequencing on root tissues from two soybean varieties (su8, high-Cd-accumulating (HAS) and su7, low Cd-accumulating (LAS)) grown with 0 or 50 μM CdSO4. A total of 18.76 million clean reads from the soybean root samples were obtained after quality assessment and data filtering. After Cd treatment, 739 differentially expressed genes (DEGs; 265 up and 474 down) were found in HAS; however, only 259 DEGs (88 up and 171 down) were found in LAS, and 64 genes were same between the two varieties. Pathway enrichment analysis suggested that after cadmium treatment, the DEGs between LAS and HAS were mainly enriched in glutathione metabolism and plant-pathogen interaction pathways. KEGG analysis showed that phenylalanine metabolism responding to cadmium stress in LAS, while ABC transporters responding to cadmium stress in HAS. Besides we found more differential expressed heavy metal transporters such as ABC transporters and zinc transporters in HAS than LAS, and there were more transcription factors differently expressed in HAS than LAS after cadmium treatment in two soybean varieties, eg. bHLH transcription factor, WRKY transcription factor and ZIP transcription factor.

Conclusions
Findings from this study will shed new insights on the underlying molecular mechanisms behind the Cd accumulation in soybean.
Development and verification of a 10K liquid chip for Hainan black goat based on genotyping by pinpoint sequencing of liquid captured targets
Authors: Meng Yong , Zhang Wencan , Cheng Yiwen , Wu Yanru , Wu Haotian , He Meirong , Chen Si , Man Churiga , Gao Hongyan , Du Li , Chen Qiaoling , Wang Fengyang 
Published: May 2024

Abstract
Background
China has thousands years of goat breeding and abundant goat genetic resources. Additionally, the Hainan black goat is one of the high-quality local goat breeds in China. In order to conserve the germplasm resources of the Hainan black goat, facilitate its genetic improvement and further protect the genetic diversity of goats, it is urgent to develop a single nucleotide polymorphism (SNP) chip for Hainan black goat.

Results
In this study, we aimed to design a 10K liquid chip for Hainan black goat based on genotyping by pinpoint sequencing of liquid captured targets (cGPS). A total of 45,588 candidate SNP sites were obtained, 10,677 of which representative SNP sites were selected to design probes, which finally covered 9,993 intervals and formed a 10K cGPS liquid chip for Hainan black goat. To verify the 10K cGPS liquid chip, some southern Chinese goat breeds and a sheep breed with similar phenotype to the Hainan black goat were selected. A total of 104 samples were used to verify the clustering ability of the 10K cGPS liquid chip for Hainan black goat. The results showed that the detection rate of sites was 97.34% -99.93%. 84.5% of SNP sites were polymorphic. The heterozygosity rate was 3.08%-36.80%. The depth of more than 99.4% sites was above 10X. The repetition rate was 99.66%-99.82%. The average consistency between cGPS liquid chip results and resequencing results was 85.58%. In addition, the phylogenetic tree clustering analysis verified that the SNP sites on the chip had better clustering ability.

Conclusion
These results indicate that we have successfully realized the development and verification of the 10K cGPS liquid chip for Hainan black goat, which provides a useful tool for the genome analysis of Hainan black goat. Moreover, the 10K cGPS liquid chip is conducive to the research and protection of Hainan black goat germplasm resources and lays a solid foundation for its subsequent breeding work.
Self-care behavior and associated factors among adult heart failure patients in outpatient cardiac follow-up unit at Wachemo University Nigist Eleni Comprehensive Specialized Hospital, Southern Ethiopia
Authors: Sugebo Ermias Sigebo , Kassie Teshager Worku , Gobena Tesfaye , Tibore Temesgen Kechine , Sebro Sisay Foga , Ermolo Tadesse Lelago 
Published: May 2024

Abstract
Background
Heart failure is a serious medical condition that occurs when the heart is unable to pump sufficient blood to meet the needs of the tissues. Good self-care is an essential behavior in long term management and maintenance of physiologic stability, better medical and person-centered outcomes. Poor self-care behavior deteriorates the outcomes of heart failure patients. However, there were no sufficient evidences that illustrate the topic in the country, including the study area.

Methodology
Institutional based cross-sectional study was conducted among 250 heart failure patients from July 5-August 4, 2021. All adult heart failure patients who fulfill the inclusion criteria and have appointment during study period were included in the study. Interview and medical chart review was used to collect data. Epidata version 3.1 and SPSS version 20 were used for data entry and analysis respectively. Bivariate and multivariable analysis was computed. The model fitness was checked by Hosmer and Lemeshow test.

Results
From the total patients, 240 were interviewed with the response rate of 96%. Among these, 140(58.3%) [95% CI: 52.6, 64.9] had poor self-care behavior. Age>54: 9.891 [2.228, 43.922], poor knowledge: 6.980[1.065, 45.727], depression: 4.973[1.107, 22.338], low social support: 6.060[1.373, 26.739], insomnia: 4.801[1.019, 22.622] and duration with heart failure <1 year: 5.782[1.438, 23.247] were factors associated with poor self-care behavior.

Conclusion
In this study, more than half of participants attending at Wachemo University Nigist Eleni Comprehensive Specialized Hospital in outpatient cardiac follow-up unit had poor self-care behavior. Of the study variables, older age, poor knowledge, depressive symptoms, low social support, insomnia and short duration with heart failure were related with poor self-care behavior. Thus, the findings highlight importance of assessing level of self-care behavior and implicate direction to take action to enhance level of self-care behavior.
Two surgical strategies (early carotid reperfusion vs. Central aortic repair-first) of acute type a aortic dissection complicated with cerebral malperfusion syndrome: a meta-analysis and systematic review
Authors: He Kang , Qin Xiaoli , Li Mei , Bian Longrong , Yue Honghua , Liang Weitao , Wu Zhong 
Published: May 2024

Abstract
Objective
Cerebral malperfusion (CM) is a common comorbidity in acute type A aortic dissection (ATAAD), which is associated with high mortality and poor neurological prognosis. This meta-analysis investigated the surgical strategy of ATAAD patients with CM, aiming to compare the difference in therapeutic effectiveness between the central repair-first and the early reperfusion-first according to clinical outcomes.

Methods
The meta-analysis and systematic review was conducted based on studies sourced from the PubMed, Embase, and Cochrane literature database, in which cases of ATAAD with CM underwent surgical repair were included. Data for baseline characteristics, mortality, survival were extracted, and risk ratio (RR) values and the pooled mortality were calculated.

Results
A total of 17 retrospective studies were analyzed, including 1010 cases of ATAAD with CM underwent surgical repair. The pooled early mortality in early reperfusion group was lower (8.1%; CI, 0.02 to 0.168) than that in the central repair group (16.2%; CI, 0.115 to 0.216). The pooled long-term mortality was 7.9% in the early reperfusion cohort and 17.4% the central repair-first cohort, without a statistically significant heterogeneity (I [2] = 51.271%; p = 0.056). The mean time of symptom-onset-to-the-operation-room in all the reports was 8.87 ± 12.3 h.

Conclusion
This meta-analysis suggested that early reperfusion-first may achieved better outcomes compared to central repair-first in ATAAD patients complicated with CM to some extent. Early operation and early restoration of cerebral perfusion may reduce the occurrence of some neurological complications.

Trial registration
: The meta-analysis was registered in the International Prospective Register of Systematic Reviews database (No. CRD CRD42023475629) on Nov. 8th, 2023.