bluuebunny/crossref_metadata_2025_split huggingface dataset:
Understanding enterprise data warehouses to support clinical and translational research: impact, sustainability, demand management, and accessibility
Authors: Campion Thomas R , Craven Catherine K , Dorr David A , Bernstam Elmer V , Knosp Boyd M 
Published: May 2024

Abstract

Objectives
Healthcare organizations, including Clinical and Translational Science Awards (CTSA) hubs funded by the National Institutes of Health, seek to enable secondary use of electronic health record (EHR) data through an enterprise data warehouse for research (EDW4R), but optimal approaches are unknown. In this qualitative study, our goal was to understand EDW4R impact, sustainability, demand management, and accessibility.

Materials and Methods
We engaged a convenience sample of informatics leaders from CTSA hubs (n = 21) for semi-structured interviews and completed a directed content analysis of interview transcripts.

Results
EDW4R have created institutional capacity for single- and multi-center studies, democratized access to EHR data for investigators from multiple disciplines, and enabled the learning health system. Bibliometrics have been challenging due to investigator non-compliance, but one hub’s requirement to link all study protocols with funding records enabled quantifying an EDW4R’s multi-million dollar impact. Sustainability of EDW4R has relied on multiple funding sources with a general shift away from the CTSA grant toward institutional and industry support. To address EDW4R demand, institutions have expanded staff, used different governance approaches, and provided investigator self-service tools. EDW4R accessibility can benefit from improved tools incorporating user-centered design, increased data literacy among scientists, expansion of informaticians in the workforce, and growth of team science.

Discussion
As investigator demand for EDW4R has increased, approaches to tracking impact, ensuring sustainability, and improving accessibility of EDW4R resources have varied.

Conclusion
This study adds to understanding of how informatics leaders seek to support investigators using EDW4R across the CTSA consortium and potentially elsewhere.
Environmental Materialities and the History of Pandemics
Authors: Webster Emily 
Published: May 2024

Abstract
Over the last several decades, a growing group of environmental and medical historians have argued that engagement with the materiality of disease is critical to eroding the false boundaries between environment and health, and especially to the historical study of major epidemics and pandemics. This article evaluates the ways in which environmental and medical historians have engaged materiality when thinking through questions of infectious disease. It argues that far from eschewing cultural constructions of disease and analysis of medical systems, these works demonstrate that engagement with materiality in the study of disease articulates the stakes of medical regimes and practices of healing, and renders legible the multiple scales at which epidemics occur. Addressing key controversies in the use of sources, it provides examples of works that incorporate material objects, biological ideas and actors, and non-humans without falling prey to the extremes of “biological determinism” or “constructivism.” It argues that commonalities in the methods employed by these works – utilization of scientific frameworks and data, multispecies analysis, attention to scale, and spatial thinking – reveal unseen and untold aspects of past pandemics. It concludes with a brief example of how these frameworks come together in practice through a case study on the history of enteric fever in Dublin, Ireland.
Post-traumatic renal arteriovenous malformation failed endovascular embolization
Authors: Alyami Ali , Alothman Ali , Balaraj Faisal , Alomairi Mohanned , Ghazwani Yahya , Albqami Nasser 
Published: May 2024

AbstractRenal arteriovenous malformations (AVMs) are abnormal connections between the renal arteries and venous system. Arteriovenous fistulas account for 70%–80% of renal arteriovenous abnormalities, often resulting from iatrogenic injuries. While most renal AVMs are asymptomatic, hematuria is a common symptom caused by AVM rupture into the renal calyces. Angiography is the gold standard for diagnosis, but noninvasive imaging techniques like ultrasound, computed tomography, or magnetic resonance imaging are commonly used for initial evaluation. Most renal AVMs are managed conservatively. Symptomatic patients typically undergo endovascular embolization, the preferred treatment, while surgery is reserved for unstable patients or those with complex vascular anatomy. We present a case of a 32-year-old man with renal AVMs following a motor vehicle accident. The patient initially received unsuccessful endovascular embolization but achieved successful treatment through open fistula ligation. This case highlights the challenges in managing renal AVMs and the importance of considering alternative interventions when initial treatments prove ineffective.
Omental infarction following robotic-assisted laparoscopic inguinal hernia repair
Authors: Hassanesfahani Maryam , Tian Jane , Keating Luke , Khan Noman , Louis Martine A , Malhotra Rajinder 
Published: May 2024

Abstract
Omental infarction (OI) is a rare condition with an overall incidence of less than 0.3%. It can occur spontaneously or can be secondary to trauma, surgery, and inflammation. While previously a diagnosis of exclusion, due to development in imaging technology, OI can now be identified based on CT findings. OI symptoms can mimic an acute abdomen, prompting potentially unnecessary surgical exploration. Treatment options range from conservative management to interventional radiology or surgical resection of the infarcted omentum. We are presenting the first case of OI following robotic-assisted inguinal hernia repair. This case highlights the importance of considering OI in differential diagnoses for patients presenting with acute abdominal pain, the utility of imaging workup in identifying OI, and guidance for conservative treatment approaches to reduce unnecessary surgical intervention.
Pure laparoscopic bilateral arcuate line hernia repair (with video)
Authors: Rappoport J , Carrasco J , Gamez B 
Published: May 2024

Abstract
An arcuate line hernia is a generally asymptomatic, ascending protrusion of intraperitoneal structures over the linea arcuata. Arcuate line herniae are scarcely reported in the literature. Only a few publications were found. No clear descriptions of the techniques for repair have been published either. We aim to provide diagnostic images and illustrate our method to repair this hernia.
Partitioning seasonal stem carbon dioxide efflux into stem respiration, bark photosynthesis, and transport-related flux in Scots pine
Authors: Dukat Paulina , Hölttä Teemu , Oren Ram , Salmon Yann , Urbaniak Marek , Vesala Timo , Aalto Juho , Lintunen Anna 
Published: May 2024

Abstract
Stem CO2 efflux is an important component of the carbon balance in forests. The efflux is considered to principally reflect the net result of two dominating and opposing processes: stem respiration and stem photosynthesis. In addition, transport of CO2 in xylem sap is thought to play an appreciable role in affecting the net flux. This work presents an approach to partition stem CO2 efflux among these processes using sap-flux data and CO2-exchange measurements from dark and transparent chambers placed on mature Scots pine (Pinus sylvestris) trees. Seasonal changes and monthly parameters describing the studied processes were determined. Respiration contributed most to stem net CO2 flux, reaching up to 79% (considering the sum of the absolute values of stem respiration, stem photosynthesis, and flux from CO2 transported in xylem sap to be 100%) in June, when stem growth was greatest. The contribution of photosynthesis accounted for up to 13% of the stem net CO2 flux, increasing over the monitoring period. CO2 transported axially with sap flow decreased towards the end of the growing season. At a reference temperature, respiration decreased starting around midsummer, while its temperature sensitivity increased during the summer. A decline was observed for photosynthetic quantum yield around midsummer together with a decrease in light-saturation point. The proposed approach facilitates modeling net stem CO2 flux at a range of time scales.
Expect the unexpected: endocarditis caused by Legionella feeleii
Authors: Moran Angelica , Otero Espinal Dennise E , Parilla Megan , Beavis Kathleen G , Mullane Kathleen M , Tesic Vera 
Published: May 2024

Abstract
We report a fatal case of Legionella feeleii endocarditis in a post–lung transplant patient. The diagnosis was delayed, as routine microbiological testing of nonrespiratory specimens does not account for extrapulmonary Legionella, and urine antigen testing only reliably detects Legionella pneumophila serogroup 1. This case also illustrates the utility of molecular sequencing for blood culture–negative endocarditis.
Gliese 12 b, a temperate Earth-sized planet at 12 parsecs discovered with TESS and CHEOPS
Authors: Dholakia Shishir , Palethorpe Larissa , Venner Alexander , Mortier Annelies , Wilson Thomas G , Huang Chelsea X , Rice Ken , Van Eylen Vincent , Nabbie Emma , Cloutier Ryan , Boschin Walter , Ciardi David , Delrez Laetitia , Dransfield Georgina , Ducrot Elsa , Essack Zahra , Everett Mark E , Gillon Michaël , Hooton Matthew J , Kunimoto Michelle , Latham David W , López-Morales Mercedes , Li Bin , Li Fan , McDermott Scott , Murphy Simon J , Murray Catriona A , Seager Sara , Timmermans Mathilde , Triaud Amaury , Turner Daisy A , Twicken Joseph D , Vanderburg Andrew , Wang Su , Wittenmyer Robert A , Wright Duncan 
Published: May 2024

ABSTRACT
We report on the discovery of Gliese 12 b, the nearest transiting temperate, Earth-sized planet found to date. Gliese 12 is a bright (V = 12.6 mag, K = 7.8 mag) metal-poor M4V star only 12.162 ± 0.005 pc away from the Solar system with one of the lowest stellar activity levels known for M-dwarfs. A planet candidate was detected by TESS based on only 3 transits in sectors 42, 43, and 57, with an ambiguity in the orbital period due to observational gaps. We performed follow-up transit observations with CHEOPS and ground-based photometry with MINERVA-Australis, SPECULOOS, and Purple Mountain Observatory, as well as further TESS observations in sector 70. We statistically validate Gliese 12 b as a planet with an orbital period of 12.76144 ± 0.00006 d and a radius of 1.0 ± 0.1 R⊕, resulting in an equilibrium temperature of ∼315 K. Gliese 12 b has excellent future prospects for precise mass measurement, which may inform how planetary internal structure is affected by the stellar compositional environment. Gliese 12 b also represents one of the best targets to study whether Earth-like planets orbiting cool stars can retain their atmospheres, a crucial step to advance our understanding of habitability on Earth and across the galaxy.
Hypothermia, bradycardia, and hypotension during glucocorticoid or cyclosporine A therapy in a boy with Kikuchi-Fujimoto disease
Authors: Hiramatsu Yasuyoshi , Takahashi Kazuki , Shimomura Masaki , Taniguchi Kota , Okura Yuka , Nawate Mitsuru , Takahashi Yutaka , Kobayashi Ichiro 
Published: May 2024

ABSTRACT
Kikuchi-Fujimoto disease (KFD) is an inflammatory disease of unknown aetiology characterised by fever and cervical lymphadenopathy. Although KFD is a self-limiting disease, patients with severe or long-lasting course require glucocorticoid therapy. We presently report a 17-year-old boy with KFD who had seven relapses since the onset at 4 years old. He suffered from hypothermia, bradycardia, and hypotension during the treatment with prednisolone or methylprednisolone. All of his vital signs recovered after cessation of the drug in addition to fluid replacement and warming. Thus, glucocorticoid was effective but could not be continued because of the adverse event. Although hypothermia developed during the treatment with 5 mg/kg/day of cyclosporine A (CsA) at his second relapse, he was successfully treated with lower-dose CsA (3 mg/kg/day). Thereafter, he had five relapses of KFD until the age of 12 years and was treated by 1.3–2.5 mg/kg/day of CsA. Hypothermia accompanied by bradycardia and hypotension developed soon after concomitant administration of ibuprofen at his fifth and sixth relapses even during low-dose CsA therapy. Conclusively, glucocorticoid, standard dose of CsA, or concomitant use of non-steroidal anti-inflammatory drugs may cause hypothermia, bradycardia, and hypotension and needs special attention. Low-dose CsA could be a choice for such cases with KFD.
#932 Obinutuzumab for the treatment of refractory PLA2R-associated membranous nephropathy: a single-center cohort study
Authors: Li Chao , Zheng Xixi , Zhang Lei , Wang Ying , Hu Rongrong , Cui Hao-Yuan , Xia Peng , Li Hang , Qin Yan , Chen Limeng , Li Xuemei , Li Xuewang 
Published: May 2024

Abstract

Background and Aims
The established first-line immunosuppressive treatment for membranous nephropathy, rituximab, is met with resistance in some cases of refractory disease. Obinutuzumab, a Type II humanized CD20 monoclonal antibody, has been documented in international case reports as a potential treatment for refractory membranous nephropathy, yet application in China is in its infancy. This study aims to investigate the preliminary short-term efficacy and safety profile of obinutuzumab in such challenging cases.

Method
We assessed six adult patients with PLA2R-associated membranous nephropathy unresponsive to rituximab, prednisone combined with cyclophosphamide, and calcineurin inhibitors. Obinutuzumab was administered intravenously at 1000 mg, preceded by prophylactic dexamethasone and diphenhydramine to mitigate infusion reactions. Immunological remission was defined as a reduction of anti-PLA2R antibodies to titers below 2RU/ml.

Results
Baseline characteristics at the initiation of obinutuzumab treatment included an average disease duration of 3.6 ± 2.1 years and a median patient age of 54 years, with a male predominance (3:1 ratio). Laboratory findings at baseline revealed serum albumin at 22 ± 4 g/L, serum creatinine at 133 ± 68 μmol/L, and a significant 24-hour urinary protein quantification (24 hUP) at 7.1 ± 2.9 g/d. The median baseline anti-PLA2R antibody titer was substantial at 90 (range 50-671) RU/ml. At follow-up (9.1 ± 3.7 months), immunological remission rates post-obinutuzumab at 1, 3, and 6 months were 33.3%, 50%, and 50%, respectively. By the end of the study, CD19+ B-cells were depleted (&lt; 5 cells/μL) for an average duration of 6.8 ± 2.6 months. At this juncture, improvements were noted with increased serum albumin (33 ± 8 g/L) and decreased serum creatinine (125 ± 80 μmol/L), along with a reduction in 24 hUP to 4.7 ± 6.2 g/L. Clinical evaluations indicated two cases of complete remission and two of partial remission. In the remaining two patients, 24 hUP was halved compared to baseline. Prednisone dosage was reduced to 7 ± 7 mg/day, with a corresponding reduction in cyclosporine and tacrolimus dosages, and cessation of cyclophosphamide and Tripterygium wilfordii polyglycosides. There were no acute infusion reactions, but two patients suffered severe infections, including one fatality, related to COVID-19 during the pandemic.

Conclusion
Obinutuzumab emerges as a novel agent in the immunosuppressive armamentarium against refractory PLA2R-associated membranous nephropathy, warranting further long-term study. The enduring B-cell depletion necessitates a careful pre-treatment risk assessment for opportunistic infections, particularly during the ongoing COVID-19 pandemic.
#2367 Membranoproliferative glomerulonephritis preceding non-Hodgkin lymphoma recurrence : a case report
Authors: Mahfoudh Olfa , Awatef Azzabi , Thabet Nesrine , Dahmene Rihem , Aicha Narjes Ben , Mrabet Senda , Guedri Yosra , Fradi Asma , Sabri Ferdaws , Boukadida Raja , Sahtout Wissal , Zellama Dorsaf 
Published: May 2024

Abstract

Background and Aims
Glomerulonephritis (GN) have been known to be associated with both chronic lymphocytic leukemia and non-Hodgkin's lymphoma. Membranoproliferative Glomerulonephritis (MPGN) is the most commonly reported histological diagnosis in these diseases.

Method
This report presented a rare case of membranoproliferative glomerulonephritis preceding non- Hodgkin lymphoma recurrence.

Results
In September 2023, we report the case of a 75-year-old woman with Sjögren's syndrome, systemic lupus erythematosus and hypertension history. Two years prior, she developed non Hodgkin lymphoma requiring chemotherapy with cyclophosphamide, prednisone, rituximab, and vincristine.
It has remained in remission. She was admitted to our department with peripheral edema complaint. Physical examination showed edema in the lower extremities. The blood pressure was 130/85 on her antihypertensive regimen. No lymphadenopathies were found.
She had mild proteinuria, microhematuria and reduced estimated glomerular filtration rate. The serum creatinine level was 190 µmol/l. She had 1.8 gr/day proteinuria.
Laboratory data showed decreased levels of serum C3, C4. Anti-nuclear antibody (ANA) screens were negative. The cryoglobulins test was negative. Hepatitis B, hepatitis C, and HIV serologies were negative.
Renal biopsy was performed and resulted as membranoproliferative glomerulonephritis with positive IgM immunofluorescence stain (Figs 1 and 2).
We therefore concluded to a membranoproliferative glomerulonephritis with monotypic immunoglobulin deposits.
After investigations, she got recurrent non-Hodgkin lymphoma diagnosis.

Discussion
GN may precede, coexist, or follow the diagnosis of lymphoma by several years.
The pathogenesis of paraneoplastic GN remains uncertain, although autoimmune mechanisms and T-lymphocyte dysfunction may be important in this respect.

Conclusion
Secondary membranoproliferative glomerulonephritis can be observed in non-Hodgkin lymphoma patients but there are few reports about clinical results of lymphoma treatment. There is limited information available concerning the effects of treatment of non-Hodgkin's lymphoma on the progression of non-Hodgkin's lymphoma associated membranoproliferative glomerulonephritis.
#1110 The AHR antagonist CH223191 alleviates kidney injury and renal fibrosis in adenine-induced chronic kidney disease
Authors: Li Hui , Ren Qian , Fu Ping , MA Liang 
Published: May 2024

Abstract

Background and Aims
The aryl hydrocarbon receptor (AhR) is a transcription factor that can be activated by a variety of endogenous and exogenous ligands, and is involved in varieties of biological processes. It has been confirmed that the expression of AhR in kidney is elevated in chronic kidney disease (CKD). However, the specific role of AhR signaling pathway in CKD and its molecular mechanism remain unclear. This study aims to investigate the role and underlying mechanism of AhR in CKD, providing potential targets for the treatment of CKD.

Method
Male C57/B6L mice were randomly divided into control group, model group and treatment group. The model group was fed 0.2% adenine diet for 14 days to establish CKD model, while the treatment group was treated with AhR antagonist CH223191. AhR agonist kynurenine and antagonist CH223191 was applied in mouse tubular epithelial (TCMK-1) cells to investigate the underlying mechanisms of AhR in vitro. The renal function, histological changes and renal fibrosis in mice were evaluated to explore the role of AhR in adenine-induced CKD. Histological changes were evaluated by PAS and MASSON stainings, immunohistochemistry and immunofluorescence. Western blot and qPCR were used to measure protein/gene transcription levels.

Results
The levels of serum creatinine (p &lt; 0.0001) and urea nitrogen (p &lt; 0.0001) in the model group were significantly increased, with obvious renal tubule dilation and renal fibrosis by PAS and MASSON staining. CH223191 treatment significantly reduced serum creatinine (p=0.0012) and urea nitrogen ( &lt; 0.0001) levels in mice, and alleviated renal fibrosis histologically. Q-PCR and Western-Blot results showed that the renal expression level of AhR in the treatment group was decreased, while the expression levels of fibronectin (Fn) (p &lt; 0.0001), α-smooth muscle actin (α-SMA) (p &lt; 0.0001), type I collagen (p=0.0007) and transforming growth factor-β (TGF-b) (p=0.0027) were significantly decreased. In addition, the expression levels of N-GAL (p &lt; 0.0001) and KIM-1 ( &lt; 0.0001) molecular markers associated with kidney injury were reduced, suggesting that inhibiting AhR expression in vivo can reduce adenine-mediated kidney injury and renal fibrosis in CKD. In vitro experiments indicated that kynurenic acid could induce the expression of AhR and AhR downstream regulatory gene CYP1b1 and upregulated fibrosis-related genes in tubular epithelial cells, while CH223191 treatment downregulated the fibrosis-related genes in tubular epithelial cells.

Conclusion
AhR mediates renal injury and renal fibrosis in adenine-induced CKD mice. AhR antagonist CH223191 exerts a renal protective effect by reducing the expression of AhR in renal tubular epithelial cells, thereby alleviating renal injury and renal fibrosis.
#915 Role of VSIG4 in renal aging process
Authors: Cha Dae Ryong , Han Sang Youb , Ko You-Jin , Cha Jin Joo 
Published: May 2024

Abstract

Background and Aims
V-set Ig domain-containing 4 (VSIG4), known for its role in inflammation and fibrosis, is particularly interesting in the realm of chronic kidney diseases. However, its specific role in kidney aging, especially under the influence of diabetes, is not well understood. This study aims to elucidate the role of VSIG4 in the aging process of kidneys, particularly in the diabetes.

Method
This study used male db/db and db/m mice, beginning from the age of eight weeks and spanning 38 weeks. Urinary albumin and VSIG4 levels were assessed using 6-hour timed urine collections and ELISA. The intrarenal expression of VSIG4 and klotho were analyzed through qRT-PCR and Western blotting.

Results
Urinary albumin levels in db/db mice were significantly higher from 8 weeks onward compared to db/m mice. These levels increased progressively with age, peaking at 38 weeks. Similarly, urinary VSIG4 levels showed a significant initial increase in db/db mice, followed by a consistent rise with age. Interestingly, both urinary albumin and VSIG4 levels in db/m mice showed a sudden surge at 38 weeks. Notably, urinary VSIG4 levels paralleled these changes in albumin levels, with a correlation coefficient of 0.867 (p &lt; 0.001). Intrarenal VSIG4 mRNA expression was markedly higher in diabetic mice and showed a significant increase at 16 and 38 weeks, with the 38-week levels being fivefold higher in db/m mice. The expression trends of VSIG4 protein were similar to its mRNA expression. The study also monitored intrarenal klotho expression to assess aging, which revealed a progressive decrease in both mRNA and protein levels with age.

Conclusion
This study highlights a significant upregulation of both urinary and intrarenal VSIG4 expressions in diabetic and non-diabetic mice. The strong association of urinary VSIG4 expression with albuminuria suggests its involvement in the renal aging process, potentially contributing to the pathogenesis of age-related kidney alterations.