bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cardiovascular risk factors and complications in patients with systemic lupus erythematosus with and without nephritis: a systematic review and meta-analysis
Authors: Wong Cheuk Yin , Ma Becky M Y , Zhang Danting , Cheung Wynn , Chan Tak Mao , Yap Desmond Y H 
Published: May 2024

IntroductionIt remains unclear how the presence of renal involvement will affect the cardiovascular (CV) risk factors and complications in patients with SLE.MethodsWe conducted a systematic review and meta-analysis using PubMed, EMBASE, MEDLINE and Scopus to identify studies published between 1947 and 2022 that evaluate the CV risk factors and complications in patients with SLE with or without lupus nephritis (LN).Results58 studies were evaluated, with 22 two-arm studies (n=8675) included in two-arm meta-analysis and 45 studies (n=385 315) included in proportional meta-analysis. Patients with SLE with LN showed significantly higher risk of hypertension (HT) (OR=4.93, 95% CI=3.17 to 7.65, p<0.00001, I2=56%), hyperlipidaemia (OR=11.03, 95% CI=4.20 to 28.95, p<0.00001, I2=0%) and diabetes mellitus (DM) (OR=1.88, 95% CI=1.09 to 3.25, p=0.02, I2=32%) compared with those without LN. Patients with LN showed numerically higher prevalence of myocardial infarction (OR=1.35, 95% CI=0.53 to 3.45, p=0.52, I2=78%) and cerebrovascular accident (OR=1.64, 95% CI=0.79 to 3.39, p=0.27, I2=23%) than general patients with SLE. The incidence rates of CV mortality are also increased in patients with SLE with LN compared with those without LN (11.7/1000 patient-years vs 3.6/1000 patient-years).ConclusionPatients with SLE with LN show increased risk of CV risk factors including DM, HT and hyperlipidaemia. Early identification and optimal control of these CV risk factors may reduce the risk of CV disease and other non-CV complications.PROSPERO registration numberCRD42022314682.
A Series Compensated Buck-Boost Converter-Based Thermoelectric Energy Harvesting System with Sliding Mode Controller
Authors: Poornima D. , Vivekanandan C. 
Published: May 2024

A thermoelectric generator (TEG) is a semiconductor-based device that can exhibit a flow of electric current through the external circuit if the sides of the TEG are subjected to a temperature difference caused by a heat source. The terminal voltage and the TEG’s internal resistance are altered depending on the temperature difference. Therefore, a suitable power electronic converter with a maximum power point tracking (MPPT) feature is required to harvest maximum power from the TEG and store the harvested energy in a battery-based energy storage system. This paper investigates a novel energy harvesting methodology from TEG using a series compensated buck-boost converter (SCBBC). MPPT has also been implemented using a sliding mode controller (SMC). A mathematical model of a TEG source has been developed in MATLAB-Simulink and tested with generic boost converter (GBC) and SCBBC for their dynamic performances during battery charging. The efficiency of conversion is found to be higher for SCBBC, at 97.87%. An experimental prototype has been developed with SCBBC and tested for two configurations, viz high voltage and low current configuration. The former configuration exhibits an efficiency of 86.3%, while the latter has an efficiency of 83%. The results indicate that SCBBC, along with SMC, opens up new efficient prospects for harvesting waste heat energy using TEGs.
On a subclass of close-to-convex functions
Authors: Dash Prachi Prajna , Prajapat Jugal Kishore 
Published: May 2024

In this paper, we define a new subclass of close-to-convex functions with respect to certain univalent functions studied by [Z. Peng and G. Zhong, Some properties for certain classes of univalent functions defined by differential inequalities, Acta Math. Sci. Ser. B[Formula: see text]Engl. Ed.[Formula: see text] 37(1) (2017) 69–78]. We find certain examples of functions belong to the class. Further, we give coefficient estimates, distortion theorem and some more results for this new subclass. Finally, we obtain radius of convexity for functions belong to the class.
Smart hydrogel catalyst with tunable activity for 4-nitrophenol reduction at different temperatures and pH
Authors: Pu Lei , Cheng Yuan , Wei Wenjing , Li Songjun 
Published: May 2024

In this study, a novel method is introduced for preparing the poly (N-isopropylacrylamideco-methacrylic acid) (PNIPAM) hydrogel catalyst (PNMC-Ag) with embedded silver nanoparticles (Ag NPs), by employing in situ reduction of Ag+ in polymeric network. The prepared hydrogel catalyst exhibits both thermal and pH responsiveness, facilitating precise control of catalytic efficiency in reducing pollutants such as 4-nitrophenol (4-NP) under varying environmental conditions. The embedded Ag NPs demonstrate remarkable stability against self-aggregation due to their confinement within the polymeric network, thus maintaining their exceptional catalytic performance over time. Leveraging the dual-responsive nature of the PNMC-Ag catalyst, tunable catalytic activity can be achieved by adjusting the temperature and pH of the reaction environment. Specifically, the Ag NPs-hydrogel catalyst exhibits high catalytic activity (21 min, 98.5%) in low-temperature ([Formula: see text]< 32°C) at neutral pH and alkaline (pH = 9) conditions at room temperature, while its activity is attenuated in high-temperature ([Formula: see text]> 32°C) at neutral pH or acidic (pH [Formula: see text]4) environments at room temperature owing to the hydrogel’s thermal and pH-responsive characteristics. This distinctive feature enables precise control over the catalytic reaction, offering an effective approach for the removal of 4-NP from wastewater using a noble-metal-containing stimuli-responsive hydrogel (SRH) catalyst. Overall, this work represents a significant step towards the development of intelligent catalytic materials with superior environmental remediation capabilities.
From Rarity to Reality: Osimertinib’s Promising Horizon in Treating Uncommon EGFR Mutations in Non–Small Cell Lung Cancer
Authors: Fukuda Akito , Okuma Yusuke 
Published: May 2024

Abstract
In the realm of advanced non–small cell lung cancer (NSCLC) harboring epidermal growth factor receptor (EGFR) therapy with tyrosine kinase inhibitors (TKI), addressing optimal treatment for uncommon EGFR mutations like G719X in exon 18, S768I in exon 20, and L861Q in exon 21 remains a pivotal yet challenging frontier. Contrary to the well-established efficacy of EGFR-TKIs in common EGFR mutations, these uncommon alterations pose unmet medical needs due to a lack of comprehensive evidence. While afatinib, a second-generation EGFR-TKI, has received FDA approval for patients with these uncommon EGFR mutations, the approval was based on a post-hoc analysis of randomized clinical trials. Recent developments include multiple clinical trials investigating the efficacy of both second- and third-generation EGFR-TKIs in patients with uncommon EGFR mutations. A noteworthy example is a prospective phase II trial of osimertinib including the landmark UNICORN study, which has shown promising results in treating uncommon EGFR mutations. Despite various reports on the efficacy of afatinib and osimertinib in treating uncommon EGFR mutations, the appropriate use of these TKIs remains unclear. This review aims to consolidate the findings from the latest clinical trials focused on uncommon EGFR mutations, outlining variations in the therapeutic efficacy of these TKIs based on the specific genetic mutation. By synthesizing these findings, we aim to guide oncologists toward more informed decisions in employing TKIs for NSCLC with uncommon EGFR mutations other than exon 20 insertion. Additionally, we explore potential treatment strategies tailored to these patient populations to address the challenges posed by these mutations.
Multi-omics Analysis of a Fecal Microbiota Transplantation Trial Identifies Novel Aspects of Acute GVHD Pathogenesis
Authors: Rashidi Armin , Ebadi Maryam , Rehman Tauseef U. , Elhusseini Heba , Kazadi David , Halaweish Hossam , Khan Mohammad H. , Hoeschen Andrea , Cao Qing , Luo Xianghua , Kabage Amanda J. , Lopez Sharon , Ramamoorthy Sivapriya , Holtan Shernan G. , Weisdorf Daniel J. , Khoruts Alexander , Staley Christopher 
Published: May 2024

Abstract

Acute GVHD (aGVHD) is a major complication of allogeneic hematopoietic cell transplantation (alloHCT) associated with gut microbiota disruptions. However, whether therapeutic microbiota modulation prevents aGVHD is unknown. We conducted a randomized, placebo-controlled trial of third-party fecal microbiota transplantation (FMT) administered at the peak of microbiota injury in 100 patients with acute myeloid leukemia receiving induction chemotherapy and alloHCT recipients. Despite improvements in microbiome diversity, expansion of commensals, and shrinkage of potential pathogens, aGVHD occurred more frequently after FMT than placebo. Although this unexpected finding could be explained by clinical differences between the two arms, we asked whether a microbiota explanation might be also present. To this end, we performed multi-omics analysis of preintervention and postintervention gut microbiome and serum metabolome. We found that postintervention expansion of Faecalibacterium, a commensal genus with gut-protective and anti-inflammatory properties under homeostatic conditions, predicted a higher risk for aGVHD. Faecalibacterium expansion occurred predominantly after FMT and was due to engraftment of unique donor taxa, suggesting that donor Faecalibacterium-derived antigens might have stimulated allogeneic immune cells. Faecalibacterium and ursodeoxycholic acid (an anti-inflammatory secondary bile acid) were negatively correlated, offering an alternative mechanistic explanation. In conclusion, we demonstrate context dependence of microbiota effects where a normally beneficial bacteria may become detrimental in disease. While FMT is a broad, community-level intervention, it may need precision engineering in ecologically complex settings where multiple perturbations (e.g., antibiotics, intestinal damage, alloimmunity) are concurrently in effect.

Significance:
Post-FMT expansion of Faecalibacterium, associated with donor microbiota engraftment, predicted a higher risk for aGVHD in alloHCT recipients. Although Faecalibacterium is a commensal genus with gut-protective and anti-inflammatory properties under homeostatic conditions, our findings suggest that it may become pathogenic in the setting of FMT after alloHCT. Our results support a future trial with precision engineering of the FMT product used as GVHD prophylaxis after alloHCT.
Incidence and Survival of Out-of-Hospital Cardiac Arrest in Public Housing Areas in 3 European Capitals
Authors: Juul Grabmayr Anne , Folke Fredrik , Samsoee Kjoelbye Julie , Andelius Linn , Krammel Mario , Ettl Florian , Sulzgruber Patrick , Krychtiuk Konstantin A. , Sasson Comilla , Stieglis Remy , van Schuppen Hans , Tan Hanno L. , van der Werf Christian , Torp-Pedersen Christian , Kjær Ersbøll Annette , Malta Hansen Carolina 
Published: May 2024

BACKGROUND:
Strategies to reach out-of-hospital cardiac arrests (called cardiac arrest) in residential areas and reduce disparities in care and outcomes are warranted. This study investigated incidences of cardiac arrests in public housing areas.

METHODS:
This register-based cohort study included cardiac arrest patients from Amsterdam (the Netherlands) from 2016 to 2021, Copenhagen (Denmark) from 2016 to 2021, and Vienna (Austria) from 2018 to 2021. Using Poisson regression adjusted for spatial correlation and city, we compared cardiac arrest incidence rates (number per square kilometer per year and number per 100 000 inhabitants per year) in public housing and other residential areas and examined the proportion of cardiac arrests within public housing and adjacent areas (100-m radius).

RESULTS:

Overall, 9152 patients were included of which 3038 (33.2%) cardiac arrests occurred in public housing areas and 2685 (29.3%) in adjacent areas. In Amsterdam, 635/1801 (35.3%) cardiac arrests occurred in public housing areas; in Copenhagen, 1036/3077 (33.7%); and in Vienna, 1367/4274 (32.0%). Public housing areas covered 42.4 (12.6%) of 336.7 km
2
and 1 024 470 (24.6%) of 4 164 700 inhabitants. Across the capitals, we observed a lower probability of 30-day survival in public housing versus other residential areas (244/2803 [8.7%] versus 783/5532 [14.2%]). The incidence rates and rate ratio of cardiac arrest in public housing versus other residential areas were incidence rate, 16.5 versus 4.1 n/km
2
per year; rate ratio, 3.46 (95% CI, 3.31–3.62) and incidence rate, 56.1 versus 36.8 n/100 000 inhabitants per year; rate ratio, 1.48 (95% CI, 1.42–1.55). The incidence rates and rate ratios in public housing versus other residential areas were consistent across the 3 capitals.

CONCLUSIONS:
Across 3 European capitals, one-third of cardiac arrests occurred in public housing areas, with an additional third in adjacent areas. Public housing areas exhibited consistently higher cardiac arrest incidences per square kilometer and 100 000 inhabitants and lower survival than other residential areas. Public housing areas could be a key target to improve cardiac arrest survival in countries with a public housing sector.
Dynamical Tests of a Deep Learning Weather Prediction Model
Authors: Hakim Gregory J. , Masanam Sanjit 
Published: May 2024

Abstract
Global deep learning weather prediction models have recently been shown to produce forecasts that rival those from physics-based models run at operational centers. It is unclear whether these models have encoded atmospheric dynamics or simply pattern matching that produces the smallest forecast error. Answering this question is crucial to establishing the utility of these models as tools for basic science. Here, we subject one such model, Pangu-Weather, to a set of four classical dynamical experiments that do not resemble the model training data. Localized perturbations to the model output and the initial conditions are added to steady time-averaged conditions, to assess the propagation speed and structural evolution of signals away from the local source. Perturbing the model physics by adding a steady tropical heat source results in a classical Matsuno–Gill response near the heating and planetary waves that radiate into the extratropics. A localized disturbance on the winter-averaged North Pacific jet stream produces realistic extratropical cyclones and fronts, including the spontaneous emergence of polar lows. Perturbing the 500-hPa height field alone yields adjustment from a state of rest to one of wind–pressure balance over ∼6 h. Localized subtropical low pressure systems produce Atlantic hurricanes, provided the initial amplitude exceeds about 4 hPa, and setting the initial humidity to zero eliminates hurricane development. We conclude that the model encodes realistic physics in all experiments and suggest that it can be used as a tool for rapidly testing a wide range of hypotheses.
Resilience and Value: Pediatric Trauma Care in Safety Net Hospitals
Authors: Motta Monique , Avila Azalia , Carroll Hayley M. , Vakil Deep , Hernandez Jennifer , Levene Tamar , Parreco Joshua P. 
Published: May 2024

Background: In the setting of limited funding and high expectations for quality care, safety net hospitals play a crucial role in treating pediatric trauma patients. This study aimed to compare outcomes and hospitalization costs of pediatric trauma patients in safety net hospitals across the United States. Methods: The Nationwide Readmissions Database for 2016-2020 was queried for all patients under the age of 18 years hospitalized for traumatic injury. Patients admitted to safety net hospitals were propensity matched 1:1 to all other patients. The primary outcome was mortality. The secondary outcomes were readmission within 1-year, mean length of stay (LOS), total charges, and total hospitalization costs including readmissions. Results: There were 176,325 patients meeting inclusion criteria, and 30,869 were admitted to safety net hospitals. All safety net patients were successfully matched across predictors, and 61,738 patients were included. The overall mortality rate was 1.4% (n = 834), and the mortality risk was similar in safety net hospitals (OR 1.11 [.96-1.27] P = .15). The overall readmission rate, mean LOS, and mean total cost were similar for safety net hospitals when compared to all hospitals. However, the overall mean total charge was $78,724 (±$224,884) and was lower in safety net hospitals ($76,575 [±$198,342], P = .02). Discussion: Safety net hospitals deliver comparable outcomes as other health care facilities when caring for pediatric trauma patients. Notably, these hospitals appear to undercharge for their services, despite incurring similar costs in the process. These results shed light on the resilience of safety net hospitals in delivering quality and cost-effective care.
Pelvic vein thrombosis in patients with pelvic venous disorders
Authors: Gavrilov Sergey G , Moskalenko Yekaterina P , Karalkin Anatoly V , Alenichev Alexander V 
Published: May 2024

Objective To assess the incidence of pelvic vein thrombosis (PVT) and outcomes of anticoagulant therapy for PVT in patients with pelvic venous disorders (PeVDs). Methods This prospective cohort study included 588 female patients with PeVDs underwent clinical examination followed by duplex ultrasound of the pelvic veins in 2021-2023. Patients with PVT were administered with anticoagulant therapy in an outpatient setting using low molecular weight heparins at a therapeutic dose. Results PVT was detected in 7.6% of patients with PeVDs and was symptomatic in 28.8% of them. The majority of asymptomatic patients had thrombosis in only one of the parametrial veins (90.6%). Anticoagulant therapy resulted in the PVT symptoms relief in all patients within 10 days and recanalization of the pelvic veins in 1-3 months. Conclusion In our study, PVT was diagnosed in 7.6% of patients with PeVDs. Anticoagulant therapy is effective and safe in resolving PVT symptoms.
Time estimates in prognostic discussions: A conversation analytic study of hospice multidisciplinary team meetings
Authors: Bruun Andrea , White Nicola , Oostendorp Linda , Stone Patrick , Bloch Steven 
Published: May 2024

Background: Recommendations state that multidisciplinary team expertise should be utilised for more accurate survival predictions. How the multidisciplinary team discusses prognoses during meetings and how they reference time, is yet to be explored. Aim: To explore how temporality is conveyed in relation to patients’ prognoses during hospice multidisciplinary team meetings. Design: Video-recordings of 24 hospice multidisciplinary team meetings were transcribed and analysed using Conversation Analysis. Setting/participants: A total of 65 staff participating in multidisciplinary team meetings in a UK hospice from May to December 2021. Results: Team members conveyed temporality in three different ways. (i) Staff stated that a patient was dying as part of the patient’s current health status. These formulations did not include a time reference per se but described the patient’s current situation (as dying) instead. (ii) Staff used specific time period references where another specific reference had been provided previously that somehow constrained the timeframe. In these cases, the prognosis would conflict with other proposed care plans. (iii) Staff members used unspecific time period references where the reference appeared vague and there was greater uncertainty about when the patient was expected to die. Conclusions: Unspecific time period references are sufficient for achieving meaningful prognostic talk in multidisciplinary teams. In-depth discussion and accurate prediction of patient prognoses are not deemed a priority nor a necessity of these meetings. Providing precise predictions may be too difficult due to uncertainty and accountability. The lack of staff pursuing more specific time references implies shared knowledge between staff and a context-specific use of prognostic estimates.
Social Determinants of Health Inequities for Older LGBT Adults: A Scoping Review
Authors: Srithumsuk Werayuth , Thummapol Onouma , Bhatarasakoon Patraporn 
Published: May 2024

Introduction: Despite the research on a health-disparate population, less is known about the social determinants of health (SDOH) inequities among older lesbian, gay, bisexual, and transgender (LGBT) adults. This scoping review aimed to explore and summarize what is known in the literature regarding the SDOH among older LGBT adults. Methods: The Joanna Briggs Institute’s (JBI) approach guided this scoping review, which examined 31 articles that included quantitative, qualitative, and mixed-method studies. Data were analyzed by three independent reviewers through a predesigned process of data charting, descriptive summary, and thematic analysis. Results: Older participants were primarily LGBT and LGB. The findings identified four intersecting dimensions of individuals, social, economic, and health care system, contributing to health inequities and poor health outcomes. Conclusion: Given the importance of SDOH for older LGBT adults, stakeholders including health care providers need to better understand the multiple intersecting influences, provide culturally congruent health care, and integrate sources of support into the care of these sexual- and gender-minority older adults.