bluuebunny/crossref_metadata_2025_split huggingface dataset:
Betone für biogenen Säureangriff im Landwirtschaftsbau
Authors: König Andreas , Rasch Stefan , Neumann Thomas , Dehn Frank 
Published: November 2010

AbstractBislang werden für landwirtschaftliche Bauten, wie z. B. Stallanlagen, Behälterbauwerke, Siloanlagen oder Biogasreaktoren, Oberflächenschutzsysteme (OS) eingesetzt, die das Eindringen von beton‐ und stahlangreifenden Agenzien verhindern sollen. Betone mit einem hohen Säurewiderstand bieten eine Alternative, um auf OS zu verzichten. Die Leistungsfähigkeit dieser Spezialbetone muss entsprechend des Schädigungspotentials der jeweiligen Anwendung durch zeitraffende Einlagerungsversuche in aggressiven Medien verifiziert werden.Für die ansteigende Anzahl von Biogasanlagen (BGA) gibt es aufgrund der noch jungen Entwicklungsgeschichte und der fehlenden Zugangsmöglichkeit in die Bauwerke bisher keine umfassenden Erfahrungen zu ablaufenden Schädigungsprozessen. In Abhängigkeit von der verwendeten Anlagenverfahrenstechnik kann prinzipiell in der Flüssigphase mit einem geringen biogenen Säureangriff, dagegen im Gasphasenbereich unter bestimmten Voraussetzungen u. a. mit einem Schwefelsäure‐, Kohlensäureangriff und mit einer Karbonatisierung gerechnet werden. Derzeit werden im Rahmen eines großangelegten Forschungsvorhabens an der MFPA Leipzig GmbH/Universität Leipzig die Schädigungspotentiale in BGA an bereits geschädigten Bauwerken und an eingelagerten Laborproben analysiert. Gleichzeitig werden durch zeitraffende Einlagerungsversuche neue säurewiderstandsfähige Betone u. a. für den Landwirtschaftsbau entwickelt.Concrete for Biogenic Acid Attack in Agricultural ConstructionsUp to present, surface protective systems are in use for agricultural buildings, for instance: cot plants, tank construction, silo plants or even biogas fermenter. The aim is to avoid infiltration by concrete‐ and steel corrosion agents. Concrete with high acid resistance are an alternative to dispense using these surface protective systems. The performance of this special‐concrete has to be verified in aggressive media through accelerated storagetests, in accordance with the potential of damage of the equivalent application.Based on the young history of development and the absent access to the buildings, none extensive experiences of the processes of damage are noted for the increasing number of biogas plants. Dependant on the used plant‐process engineering, a less biogenic acid attack within the liquid state can be expected. Within the gaseous phase under special conditions i.a. sulfuric acid‐, carbonic acid attack and carbonation can simultaneously occur. Currently, in the context of the large‐scale research project at the MFPA Leipzig GmbH/Leipzig University, the potentials of damage within biogas plants on damaged buildings as well as embedded samples become analyzed. At the same time new acid resistance concretes, i.a. for agricultural buildings will be developed by accelerated storage‐tests.
Safety and efficacy of drug eluting stents compared with bare metal stents for saphenous vein graft interventions: A comprehensive meta‐analysis of randomized trials and observational studies comprising 7,994 patients
Authors: Hakeem Abdul , Helmy Tarek , Munsif Siddharth , Bhatti Sabha , Mazraeshahi Reza , Cilingiroglu Mehmet , Effat Mohamed , Leesar Massoud , Arif Imran 
Published: November 2010

AbstractBackground: Saphenous vein graft (SVG) lesions remain amongst the most challenging lesions for percutaneous coronary intervention (PCI). It is unknown whether drug eluting stents (DES) are superior to bare metal stents (BMS) for such lesions. Our objective is to determine the safety and efficacy of DES compared with BMS for SVG lesions by performing a meta‐analysis of clinical trials and observational studies. Data Sources: PubMed, Cochrane Register of Controlled Trials, conference proceedings, and internet‐based resources of clinical trials. Study Selection:Studies comparing DES vs. BMS for SVG lesions with at least > 30 patients in each study reporting the outcomes of interest [death, myocardial infarction (MI), target vessel revascularization (TVR), stent thrombosis (ST), and the composite of death, TVR and MI (major adverse cardiac events; MACE)] with at least 6 months clinical follow‐up. The primary outcome of interest was death. Results:Two randomized trials, one subgroup analysis of a randomized trial and 26 observational studies comprising a total of 7,994 patients (4,187 patients in DES and 3,807 patients in BMS group) were included in the analysis .Mean follow‐up duration was 21 ± 11 months (6–48 months). In the overall population, MACE events were 19% in DES and 28% in BMS with a risk ratio (RR) of 0.7 (0.6, 0.8) P < 0.00001. This effect of MACE was sustained in studies with >2 years follow‐up with RR of 0.77 (0.65, 0.91) P = 0.003. Death rate was 7.8% in DES and 9% in BMS with a RR of 0.82 (0.7, 0.97) P = 0.02. MI rate was 5.7% in DES and 7.6% in BMS with RR of 0.72 (0.57, 0.91) P = 0.007. TVR was 12% in DES and 17% in BMS with RR of 0.71 (0.59, 0.85) P = 0.0002. ST was 1% in DES and 1.7 % in BMS RR of 0.61 (0.35, 1.06) P = 0.08. Specifically in randomized controlled trials, DES were associated with no significant differences in overall mortality [RR = 1.97; 95% confidence interval (CI), 0.17–23; P = 0.58] or MI (RR = 1.24; 95% CI, 0.3–5.5; P = 0.78) compared with BMS. Conclusions:Based on the results of this meta‐analysis, DES may be considered as a safe and efficacious option for the percutaneous intervention of SVG lesions. © 2010 Wiley‐Liss, Inc.
Sunitinib rechallenge in metastatic renal cell carcinoma patients
Authors: Zama Ivan N. , Hutson Thomas E. , Elson Paul , Cleary James M. , Choueiri Toni K. , Heng Daniel Y.C. , Ramaiya Nikhil , Michaelson M. Dror , Garcia Jorge A. , Knox Jennifer J. , Escudier Bernard , Rini Brian I. 
Published: November 2010

AbstractBACKGROUND:Sunitinib was a standard initial therapy in metastatic renal cell carcinoma (mRCC). Given the fact that many patients progressed through many available therapies and antitumor activity had been demonstrated with sequential vascular endothelial growth factor‐targeting approaches, a retrospective review was performed of the experience of rechallenge with sunitinib in sunitinib‐refractory mRCC.METHODS:mRCC patients who received sunitinib therapy after disease progression on prior sunitinib and other therapy were retrospectively identified. Patient characteristics, toxicity, clinical outcome, Response Evaluation Criteria in Solid Tumors (RECIST) objective response rate, and progression‐free survival (PFS) were recorded.RESULTS:Twenty‐three mRCC patients who were rechallenged with sunitinib were identified. Upon rechallenge, 5 patients (22%) achieved an objective partial response. The median PFS with initial treatment was 13.7 months and 7.2 months with rechallenge. Patients with >6‐month interval between sunitinib treatments had a longer PFS with rechallenge than patients who started the rechallenge within 6 months (median PFS, 16.5 vs 6.0 months; P = .03). There was no significant difference in outcome to sunitinib rechallenge based on number or mechanism of intervening treatments. Substantial new toxicity or significantly increased severity of prior toxicity was not seen during rechallenge in this cohort.CONCLUSIONS:Sunitinib rechallenge had potential benefits and was tolerated in select metastatic RCC patients. Additional prospective investigation was warranted. Cancer 2010. © 2010 American Cancer Society.
Cryptococcus peritonitis a rare manifestation in HIV positive host: A case report
Authors: Singh Puja , Joshi Deepti , Gangane Nitin 
Published: November 2010

AbstractCryptococcus neoformans is an encapsulated yeast found ubiquitously in the environment and causes serious infections in immunocompromised populations. Disseminated disease is uncommon and very rarely manifests as peritonitis. We report a case of cryptococcal peritonitis in a HIV positive patient, who presented with distention of abdomen, vomiting, and dyspnoea, where the diagnosis was made on cytological smears of ascitic fluid. The importance of making a quick diagnosis utilizing cytological smears is emphasized and the cytological features are demonstrated. Disseminated cryptococcosis, particularly with peritonitis, is an uncommon manifestation of C. neoformans infection. A high clinical suspicion and early initiation of therapy is needed to recognize and treat patients effectively. Diagn. Cytopathol. 2011. © 2010 Wiley‐Liss, Inc.
Comparative evaluation of fine needle aspiration cytology, culture, and PCR in diagnosis of tuberculous lymphadenitis
Authors: Mittal Preeti , Handa Uma , Mohan Harsh , Gupta Varsha 
Published: November 2010

AbstractIn developing countries, where tuberculosis (TB) is still rampant, tuberculous lymphadenopathy (TB LAP) is one of the most common causes of LAP. Rapid diagnosis and adequate treatment are very important. As a primary diagnostic tool, fine needle aspiration cytology (FNAC) has provided an efficient alternative to excision. Cytologic diagnosis can be made with cytomorphologic features of well‐formed epithelioid granulomas and the presence of caseous necrosis. However, bacteriological confirmation is essential because of the presence of various granulomatous inflammation. This study was performed to evaluate and compare the role of FNAC, mycobacterial culture, and PCR in diagnosing tuberculous lymphadenitis. FNA material was collected from 50 patients and was subjected to analysis by cytomorphology, ZN stain, M. tuberculosis culture, and PCR. Out of 50 cases, 36 cases showed cytological features consistent with TB. The most common cytomorphological pattern was epithelioid cell granulomas along with necrosis seen in 17 cases (34%), followed by necrosis only in 13 cases(26%). TBLAP was correctly diagnosed by acid‐fast bacilli (AFB) smear in 26 cases, by culture in 30 cases and by PCR in 30 cases. Overall sensitivity of AFB smear was 76.47% and that of culture as well as PCR was 88.23%. In conclusion, presence of granulomas and caseation necrosis are highly suggestive of tubercular etiology, especially in scenario of developing countries where incidence of TB is high. Cytomorphology can be supplemented with AFB smear and culture wherever required and PCR should be kept as a reserve method for equivocal cases. Diagn. Cytopathol. 2011. © 2010 Wiley‐Liss, Inc.
Cutaneous and subcutaneous metastases from internal malignancies: An analysis of cases diagnosed by fine needle aspiration
Authors: Bansal Rimpi , Patel Trupti , Sarin Jatin , Parikh Biren , Ohri Anupam , Trivedi Priti 
Published: November 2010

AbstractCutaneous and subcutaneous metastases from internal malignancies are rare and indicate a dismal outcome for the patient. This study is designed to analyze cases of cutaneous and subcutaneous metastases from a known or unknown primary and evaluate usefulness of fine needle aspiration cytology as a diagnostic modality. The present study is a retrospective analysis of 83 patients who were diagnosed with metastatic skin deposits on fine needle aspiration cytology. Seventy‐four patients were previously diagnosed cases of malignancy and nine patients had metastatic deposits simultaneously with the primary tumor. The commonest malignancies showing cutaneous metastases were from breast, colon and rectum, lung, ovary, and thyroid. The differential diagnoses are from primary cutaneous tumors. FNAC provides a rapid diagnosis and should be used as a preferred first line diagnostic modality in such patients. In our study, FNAC yielded a sensitivity and specificity of 100% as a microscopic method for confirmation. Diagn. Cytopathol. 2011. © 2010 Wiley Periodicals, Inc.
Adenomatoid nodules are the main cause for discrepant histology in 234 thyroid fine‐needle aspirates reported as follicular neoplasm
Authors: Schreiner Andrew M. , Yang Grace C. H. 
Published: November 2010

AbstractAccording to several large studies, the surgical pathologist renders a non‐neoplastic diagnosis in ∼20–40% of thyroid fine‐needle aspiration (FNA) cases reported as follicular neoplasm. This study analyzes the cause of this poor correlation between cytology and histology. Cases consisting of oncocytic (Hurthle) cells were excluded from study. During the study period from January 1996 to April 2010, histologic follow‐up was available for 234 of 670 cases (34.9%) reported as follicular neoplasm on ultrasound‐guided thyroid FNA. Sonographic and Doppler data were available in all cases and included nodule location, size, echogenicity, and vascularity. Of the 234 aspirates with follow‐up, surgical pathology reported 130 cases (55.6%) of follicular adenoma, 15 cases (6.4%) of follicular carcinoma, 14 cases (6.1%) of follicular variant of papillary carcinoma, and 75 cases (32.3%) of nodular goiter. Recuts of those index nodules reported as nodular goiter were examined independently by two pathologists using the 2× objective lens. Adenomatoid nodule was defined as an insufficiently encapsulated “blue” nodule of increased nuclear density when compared with the surrounding thyroid. Of the 75 cases reported as nodular goiter, 60 index nodules (80%) fulfilled the described criteria for adenomatoid nodule, while 15 did not. In conclusion, adenomatoid nodules are the main cause of poor histologic correlation with follicular neoplasm reported by FNA. If “increased nuclear density at scanning magnification” were adopted by surgical pathologists as the major diagnostic criterion for follicular adenoma rather than encapsulation, noncorrelated cases would be reduced from 32 to 6.4%. Diagn. Cytopathol. 2010. © 2010 Wiley‐Liss, Inc.
Utility of the Thin Prep Imaging System® in the detection of squamous intraepithelial abnormalities on retrospective evaluation: Can we trust the imager?
Authors: Barroeta Julieta E. , Reilly Mary E. , Steinhoff Margaret M. , Lawrence W. Dwayne 
Published: November 2010

AbstractProspective studies analyzing the ThinPrep Imaging System (TIS) have demonstrated a significant decrease in screening time and detection rates comparable or better than manual screening. We retrospectively analyzed the accuracy of the TIS in detecting cervical abnormalities. Our study included all new HSIL diagnoses in 2007 with previous negative (NIL) pap tests screened with TIS. The original 22 fields of view (FOV) were reviewed by 2 blinded screeners followed by manual screening of all slides. Any ASC‐US or above was considered “abnormal.” Of a total of 111,080 pap tests performed in 2007, 180 were reported as HSIL. Of these, 45 cases had a previous NIL pap diagnosed within the last year, screened with TIS. Following re‐examination of the NIL pap, 31 diagnoses remained unchanged and 9 were reclassified as abnormal on the basis of cells present within the original FOV. When manually reviewed, all nine cases were confirmed as abnormal. Four cases were reclassified as abnormal on the basis of the manual screen (abnormal cells absent in the FOV). The sensitivity of TIS for the detection of abnormality was 99.95% (false‐negative rate FNR: 0.05%) and the sensitivity for detection of HSIL was 99.07% (FNR: 0.92%). When analyzing the cytotechnologist interpretation of the FOV, the sensitivity for detection of abnormality and HSIL was 99.89% (FNR: 0.1%), and 99.53% (FNR: 0.4%), respectively. On retrospective analysis based on newly diagnosed HSIL cases, the sensitivity of TIS was comparable to that of manual screening with a slightly decreased rate of false negatives. Diagn. Cytopathol. 2011. © 2010 Wiley Periodicals, Inc.
Metastatic disease to the pancreas documented by endoscopic ultrasound guided fine‐needle aspiration: A seven‐year experience
Authors: Layfield Lester J. , Hirschowitz Sharon L. , Adler Douglas G. 
Published: November 2010

AbstractThe study was performed to determine the frequency and origin for metastatic disease to the pancreas as found in an endoscopic ultrasound directed fine‐needle aspiration series.The records of the Departments of Pathology at the University of Utah School of Medicine and the David Geffen School of Medicine were electronically searched for all fine‐needle aspirates obtained from pancreatic masses between January 1, 2002 and March 31, 2010. All cases with a diagnosis of metastatic disease were reviewed and whenever possible correlated with subsequent resection specimens.A total of 17 metastatic malignancies to the pancreas were detected in pancreatic FNAs representing 0.73% of all cases. Primaries included eight renal cell carcinomas, one medullary carcinoma of the thyroid, four lymphomas, one alveolar rhabdomyosarcoma, one squamous cell carcinoma derived from the esophagus, and a second squamous cell carcinoma originating from a lung primary and a small cell carcinoma of the lung.Metastatic renal cell carcinoma was the most frequent metastasis to the pancreas representing 47% of metastatic lesions detected by FNA. The metastatic deposits could be detected in the pancreas as many as 10 years following the original diagnosis and resection of the renal cell carcinoma. Diagn. Cytopathol. 2012. © 2010 Wiley Periodicals, Inc.
Facile Formation of a Rhenium Allenylcarbene Complex with an Internal Dithioalkyne
Authors: Seidel Wolfram W. , Meel Matthias J. , Schallenberg David , Pape Tania , Villinger Alexander , Michalik Dirk 
Published: November 2010

AbstractThe η2‐alkyne complex [(η5‐C5H5)Re(1)Br2], 2, (1 = BnSC2SBn) reacts with an excess of the dithioalkyne 1 to give the addition product [(η5‐C5H5)ReBr2{η3‐(BnS)2C2C(SBn)C(SBn)}], 3, displaying a ReC3 ring with an exocyclic double bond. The molecular structures of the complexes 2 and 3 were determined by single‐crystal X‐ray diffraction. The nonplanarity of the ReC3 ring and the largely equal C–C bond lengths within the ring reveal 3 to be a resonance hybrid of an allenylcarbene complex and a folded rhenacyclobutene system. DFT calculations show that complex type 3 is favorable over the isomeric η4‐cyclobutadiene complex 3a with four thiobenzyl substituents, while the opposite holds true for the phenyl‐substituted derivative. According to calculations on potential intermediates and transition states, the rate‐determining step is the conversion of a bis(alkyne) into a mixed alkyne/vinylidene complex by 1,2‐SBn shift, while the formation of 3 via the η4‐cyclobutadiene complex 3a is improbable. Allenyl carbene complexes are of great interest as alkyne polymerization intermediates.
Astrocytes are GABAergic cells that modulate microglial activity
Authors: Lee Moonhee , Schwab Claudia , Mcgeer Patrick L. 
Published: November 2010

AbstractGABA is assumed to function in brain only as an inhibitory neurotransmitter. Here we report a much broader CNS role. We show that human astrocytes are GABAergic cells, and that human microglia are GABAceptive cells. We show that in adult human brain tissue, astrocytes immunostain for the GABA synthesizing enzyme GAD 67, the GABA metabolizing enzyme GABA‐T and the GABAA and GABAB receptors. The intensity of staining is comparable or greater to that observed for known inhibitory neurons. We show that cultured human astrocytes strongly express the mRNA and protein for GAD 67, as well as GABA‐T, and the GABAA and GABAB receptors. We further show that cultured human microglia express the mRNA and protein for GABA‐T, in addition to the GABAA and GABAB receptors characterizing them as GABAceptive cells. We demonstrate that GABA suppresses the reactive response of both astrocytes and microglia to the inflammatory stimulants lipopolysaccharide (LPS) and interferon‐γ by inhibiting induction of inflammatory pathways mediated by NFκB and P38 MAP kinase. This results in a reduced release of the inflammatory cytokines TNFα and IL‐6 and an attenuation of conditioned medium neurotoxicity toward neuroblastoma SH‐SY5Y cells. These inhibitory reactions are partially mimicked by the GABAA receptor agonist muscimol and the GABAB receptor agonist baclofen, indicating that GABA can stimulate both types of receptors in astrocytes as well as microglia. We conclude that the antiinflammatory actions of GABA offer new therapeutic opportunities since agonists should enhance the effectiveness of other antiinflammatory agents that operate through non‐GABA pathways. © 2010 Wiley‐Liss, Inc.
Attaching Different Kinds of Proteinaceous Nanospheres to a Variety of Fabrics Using Ultrasound Radiation
Authors: Angel (Shimanovich) Ulyana , Silva Carla Manuela , Cavaco‐Paulo Artur , Gedanken Aharon 
Published: November 2010

AbstractThe application of a rapid, non‐destructive, cost‐effective technique such as ultrasonic emulsification for the coating of different textiles was explored. The technical benefits for this research were the generation of multifunctional materials and their combinations through environmentally friendly processing technologies. We have shown for the first time that ultrasonic waves can be used to coat proteinaceous micro‐ and nanospheres (PM) of BSA (Bovine Serum Albumin) protein and casein on the surface of cotton and polyester (PE) fabrics. The creation and the anchoring of the microbubbles to the fabrics were performed by a one‐step reaction, and the process is usually stopped after 3 min. The PM of bovine serum albumin (BSA) bonded to cotton and polyester fabrics has shown stability for ∼9 months. The PMs were shown to be attached more strongly to the polyester than to the cotton, and sustained stronger washing conditions on PE. The diameter of the BSA and the casein spheres on cotton was in the range of 0.8–1.0 μm, while on the PE it varied between 60 and 120 nm.
Sensitivity to change of youth treatment outcome measures: a comparison of the CBCL, BASC‐2, and Y‐OQ
Authors: McClendon Debra T. , Warren Jared S. , M. Green Katherine , Burlingame Gary M. , Eggett Dennis L. , McClendon Richard J. 
Published: November 2010

AbstractThis study evaluated the relative sensitivity to change of the Child Behavior Checklist/6–18 (CBCL), the Behavior Assessment System for Children‐2 (BASC‐2), and the Youth Outcome Questionnaire 2.01 (Y‐OQ). Participants were 134 parents and 44 adolescents receiving routine outpatient services in a community mental health system. Hierarchical linear modeling analyses were used to examine change trajectories for the 3 measures across 3 groups: parent informants, parent and adolescent dyads, and adolescent informants. Results indicated that for parent‐report measures, the Y‐OQ was most change sensitive; the BASC‐2 and CBCL were not statistically different from each other. Significant differences in change sensitivity were not observed for youth self‐report of symptoms. Results suggest that the Y‐OQ may be particularly useful for evaluating change in overall psychosocial functioning in children and adolescents. © 2010 Wiley Periodicals, Inc. J Clin Psychol 00:1–15, 2010.