bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impacts of epigenetic reprogramming on innate immunity
Authors: Fu Jie , Wang Yizhen 
Published: June 2024

Abstract
The innate immune response is the host’s first line of defense, promptly activated upon pathogen invasion. Its precise and rapid activation relies on innate immune cells (IICs). Upon recognizing danger signals postinfection or injury, they release various innate immune effectors to eliminate invading pathogens or damaged cells, thus supporting the host’s immune homeostasis. Epigenetic modifications, by shaping chromatin structures, orchestrate specific gene transcription patterns to regulate the lineage development, differentiation, and activation of IICs. This intricate process ultimately contributes to effective pathogen clearance and IICs’ healthy development and differentiation. To thoroughly elucidate the epigenetic mechanisms underlying the development and differentiation of IICs, this review first introduces the fundamental concepts and latest advancements in this field. We then delve into how the immune microenvironment or other signaling molecules shape the epigenetic landscapes of distinct IIC subsets during their lineage development and differentiation. Furthermore, we summarize how different epigenetic modification profiles mediate specific transcriptional patterns, thereby influencing the lineage development, differentiation, and activation of IICs in response to infections or injuries. Finally, we discuss several unresolved critical issues from the perspective of targeting epigenetic modifications to modulate the innate immune response. In summary, this review aims to uncover the molecular mechanisms underlying the development, differentiation, and activation of IICs from an epigenetic perspective, providing theoretical foundations for scientific and medical researchers pursuing disease treatments.
Carbapenemase-producing Enterobacterales isolated from hospital sinks: molecular relationships with isolates from patients and the change in contamination status after daily disinfection with sodium hypochlorite
Authors: Shikama Yoshiaki , Yokoya Chiemi , Ohara Akira , Yamashita Megumi , Shimizu Yuichi , Imagawa Tomoyuki 
Published: June 2024

Abstract

Objective:
This study aimed to investigate the contamination status of hospital sinks with carbapenemase-producing Enterobacterales (CPE), the efficacy of daily cleaning with sodium hypochlorite, and the relationships between CPEs isolated from contaminated sinks and patients.

Design:
Pre/postintervention surveys of the CPE-contaminated sinks.

Setting:
Hospital wards including pediatric intensive care unit in a children’s hospital.

Participants:
Consenting CPE-colonized patients admitted between November 2018 and June 2021 in our hospital.

Methods:
Environmental culture of 180 sinks from nine wards in our hospital was performed three times with an interval of 2 years (2019, 2021, 2023). Molecular typing of the isolated strains from the sinks and patients was performed. After the first surveillance culture, we initiated daily disinfection of the sinks using sodium hypochlorite.

Results:
Before the intervention, we detected 30 CPE-positive sinks in 2019. After the intervention with sodium hypochlorite, we observed a substantial decline in the number of sinks contaminated with CPE; 13 in 2021 and 6 in 2023. However, the intervention did not significantly reduce the number of CPE-contaminated sinks used for the disposal of nutrition-rich substances. The CPE isolates from the patients and those from the sinks of the wards or floors where they were admitted tended to have similar pulse-field gel electrophoresis patterns.

Conclusion:
Contaminated sinks could be reservoirs of disseminating CPE to the patients. Daily disinfection of sinks with sodium hypochlorite may be effective in eliminating CPE, although the effect could be weaker in sinks with a greater risk of contact with nutrition-rich substances.
The changing epidemiology of Clostridioides difficile infection and the NAP1/027 strain in two Québec hospitals: a 17-year time-series study
Authors: Couture Sandrine , Frenette Charles , Schiller Ian , Alfaro Rowin , Dendukuri Nandini , Thirion Daniel , Longtin Yves , Loo Vivian G. 
Published: June 2024

Abstract

Objective:
To describe the epidemiology of healthcare-associated Clostridioides difficile infection (HA-CDI) in two Québec hospitals in Canada following the 2003 epidemic and to evaluate the impact of antibiotic stewardship on the incidence of HA-CDI and the NAP1/027 strain.

Design:
Time-series analysis.

Setting:
Two Canadian tertiary care hospitals based in Montréal, Québec.

Patients:
Patients with a positive assay for toxigenic C. difficile were identified through infection control surveillance. All cases of HA-CDI, defined as symptoms occurring after 72 hours of hospital admission or within 4 weeks of hospitalization, were included.

Methods:
The incidence of HA-CDI and antibiotic utilization from 2003 to 2020 were analyzed with available C. difficile isolates. The impact of antibiotic utilization on HA-CDI incidence was estimated by a dynamic regression time-series model. Antibiotic utilization and the proportion of NAP1/027 strains were compared biannually for available isolates from 2010 to 2020.

Results:
The incidence of HA-CDI decreased between 2003 and 2020 at both hospitals from 26.5 cases per 10,000 patient-days in 2003 to 4.9 cases per 10,000 patient-days in 2020 respectively. Over the study period, there were an increase in the utilization of third-generation cephalosporins and a decrease in usage of fluoroquinolones and clindamycin. A decrease in fluoroquinolone utilization was associated with a significant decrease in HA-CDI incidence as well as decrease in the NAP1/027 strain by approximately 80% in both hospitals.

Conclusions:
Decreased utilization of fluoroquinolones in two Québec hospitals was associated with a decrease in the incidence of HA-CDI and a genotype shift from NAP1/027 to non-NAP1/027 strains.
Low Yield of Routine Cerebrospinal Fluid Analysis to Assess for An Autoimmune Etiology in Patients with Chronic Seizures of Unknown Cause
Authors: Daub Meaghan , Sangam Kamala , Burneo Jorge G. , Budhram Adrian 
Published: June 2024

ABSTRACTIn this study, we examined the yield of routine cerebrospinal fluid (CSF) analysis to assess for an autoimmune etiology in patients with chronic seizures of unknown cause. Forty-seven patients were included. Six of 47 (13%) had inflammation on routine CSF analysis, none of whom were diagnosed with seizures related to autoimmune encephalitis (AE). Meanwhile, 2/47 (4%) were diagnosed with seizures related to AE, neither of whom had inflammation on routine CSF analysis. Routine CSF analysis to assess for an autoimmune etiology in patients with chronic seizures of unknown cause is low yield, and has suboptimal specificity and sensitivity for seizures related to AE.
A qualitative study exploring the challenges for a national police force as first responders to children and young people presenting with mental health crises: perspectives of emergency department professionals
Authors: Bond L. , Rooney L. , Healy D. , McNicholas F. 
Published: June 2024

Abstract

Introduction:
The difficulties in accessing Child and Adolescent Mental Health Services (CAMHS) and the lack of out-of-hours and crises services have resulted in Ireland’s national police force, An Garda Síochána (GS), becoming increasingly involved as first responders to children and young people (CYP) who are experiencing potential mental health crises.

Aims:
To outline challenges faced by members of GS and emergency department (ED) professionals in such cases.

Method:
Qualitative study design with semi-structured interviews conducted with a convenience sample of medical and mental health professionals (n = 11) from a paediatric ED who are frequently involved with the interface between GS and CYP experiencing potential mental health crises. Thematic analysis was conducted on transcribed interviews using the software package MaxQDA to systematically organise and code transcriptions.

Results:
Participants highlighted a lack of appropriate clinical settings within the ED for CYP who attend with a mental health crisis through GS. Whilst participants described positive rapport between GS and ED staff, interactions between GS and patients were identified as challenging. Knowledge gaps amongst members of GS in Mental Health Act (MHA) legislation and restraint were also identified as contributory stressors for GS and emergency department professionals.

Conclusion:
The increased prevalence of CYP mental health issues and psychosocial stressors in conjunction with difficulty in accessing CAMHS means that challenges faced by GS as first responders are likely to continue. Research is needed to quantify the adverse personal impacts on GS along with the potential negative impact on youth. Access to emergency mental health review for youth is essential to optimise the experience of both groups.
“A romance based on information”: The curious case of Clements Markham’s Franklin Expedition novel
Authors: Rosenberg Allegra 
Published: June 2024

Abstract
Sir Clements Markham (1830-1916), secretary of the Royal Geographical Society for many decades, is best known for his role in shaping the Heroic Age of Antarctic Exploration and especially the career of his protege Robert Falcon Scott. His unpublished work of Franklin Expedition fiction, a 350-page handwritten manuscript held in the collection of the RGS, is an understudied artefact which has much to say about Markham’s life, work, and ideology. A work of fact-based history, yet also a fantasy on themes of chivalry, his 1899 novel James Fitzjames…, while occasionally mined for biographical information by scholars of the 19th-century Arctic, has never been fully evaluated on its own terms. An initial read reveals various preoccupations: Christian spirituality; the male body in extremis; loyalty to the imperial hierarchy; and a deep interest in establishing James Fitzjames as a heroic figure for posterity. In this paper, I aim to uncover various meanings embedded in this romance, place it into the ongoing literary afterlife of the Franklin Expedition, and demonstrate some of the insights it can offer regarding Markham’s role as a vital figure in the history of polar exploration.
An Investigation on Potential Dispersal of Airborne Pollen Over China and Their Impact on Climate as Ice Nuclei Using RegCM‐Pollen
Authors: Song Rong , Wang Tijian , Li Shu , Zhuang Bingliang , Li Mengmeng , Xie Min , Luo Chuanxiu , Kilifarska‐Nedialkova Natalya Andreeva 
Published: June 2024

AbstractPollen can serve as an effective ice‐nuclei (IN), altering cloud microphysical and radiative properties, thus precipitation and cloud life cycles. Here, a nationwide pollen emission inventory with a horizontal resolution of 5 km was established based on a parameterization scheme of mass balance of pollen grain fluxes surrounding the plant crowns, and using satellite observational data sets (including leaf area index and fractional vegetation cover) as well as pollen emission rates. The potential emission is then implemented in RegCM‐pollen model which treated pollen as aerosol tracers. Besides, pollen‐IN parameterization schemes were incorporated in RegCM‐pollen to simulate the interactions between pollen and ice clouds. Investigations show that the mean annual pollen emission in China is 2.65 × 107 grains m−2 yr−1, mainly distributed in the south and northeast of China. The IN magnitude is mainly determined by a combination of temperature and pollen concentration. Notably, an increasing number concentration of pollen grains produces opposite effects in Southern China (SC) and Northern China (NC). The weakened upward motion and vertical transport of water vapor in NC made ice clouds hardly form, resulting in cloud forcing (CF) of +0.86 W/m2. In contrast, it generates a CF of −0.84 W/m2 in SC mainly owing to expanded cloud cover. The changes in shortwave radiative forcing is more significant compared to longwave radiative forcing in the two regions. At the surface, the net radiative forcing in NC is +0.74 W/m2, while it is a −0.51 W/m2 in SC. Among them, downward shortwave radiative forcing is approximately twice that of upward longwave radiative forcing in SC and 1.4 times in NC. Surface temperature shows rising over NC, ranging from 0.05 to 0.25 K. In SC, it is primarily decreasing by −0.12 to −0.03 K. The pollen‐IN effect also causes a decline of precipitation in NC (−0.17 mm/day) and a rise in SC (0.09 mm/day). Our results suggest that the pollen effect on ice clouds is complex, yet significant in understanding its impact on radiation and climate of the atmosphere.
Experimental Evidence of Primary Permeability at Very Low Gas Content in Crystal‐Rich Silicic Magma
Authors: Theurel Anna , Collombet Marielle , Burgisser Alain , Martel Caroline , Arbaret Laurent , Champallier Rémi 
Published: June 2024

AbstractEruptive dynamics is influenced by gas escape from the ascending magma. Gas pathways form in the magma via bubble coalescence, leading to gas channeling. Magmatic crystals play a key role in gas channel formation. This work constrains experimentally decompression‐induced coalescence in high‐crystallinity silicic magmas without external deformation, focusing on low gas content and bimodal crystal size (microlites and phenocrysts). All percolating samples have permeabilities of 10−14 m2 at bulk porosities of 7–10 vol% and bulk crystallinities up to 75 vol%. Our results demonstrate the possibility of coalescence‐related outgassing at high pressure (120–350 MPa) and without external strain, which corresponds to magma stagnating deep in a volcanic conduit. Channeling at such low gas content implies that bimodal crystallinity favors effusive over explosive volcanic behavior. It may also be the missing physical mechanism explaining gas transfer across magmatic systems despite high melt viscosity and low or absent magma extrusion.
Observation of Io's Resurfacing via Plume Deposition Using Ground‐Based Adaptive Optics at Visible Wavelengths With LBT SHARK‐VIS
Authors: Conrad Al , Pedichini Fernando , Li Causi Gianluca , Antoniucci Simone , de Pater Imke , Davies Ashley Gerard , de Kleer Katherine , Piazzesi Roberto , Testa Vincenzo , Vaccari Piero , Vicinanza Martina , Power Jennifer , Ertel Steve , Shields Joseph C. , Ragland Sam , Giorgi Fabrizio , Jefferies Stuart M. , Hope Douglas , Perry Jason , Williams David A. , Nelson David M. 
Published: June 2024

AbstractSince volcanic activity was first discovered on Io from Voyager images in 1979, changes on Io's surface have been monitored from both spacecraft and ground‐based telescopes. Here, we present the highest spatial resolution images of Io ever obtained from a ground‐based telescope. These images, acquired by the SHARK‐VIS instrument on the Large Binocular Telescope, show evidence of a major resurfacing event on Io's trailing hemisphere. When compared to the most recent spacecraft images, the SHARK‐VIS images show that a plume deposit from a powerful eruption at Pillan Patera has covered part of the long‐lived Pele plume deposit. Although this type of resurfacing event may be common on Io, few have been detected due to the rarity of spacecraft visits and the previously low spatial resolution available from Earth‐based telescopes. The SHARK‐VIS instrument ushers in a new era of high resolution imaging of Io's surface using adaptive optics at visible wavelengths.
Large Uncertainties When Diagnosing the “Eddy Feedback Parameter” and Its Role in the Signal‐To‐Noise Paradox
Authors: Saffin Leo , McKenna Christine M. , Bonnet Rémy , Maycock Amanda C. 
Published: June 2024

AbstractA too‐weak eddy feedback in models has been proposed to explain the signal‐to‐noise paradox in seasonal‐to‐decadal forecasts of the winter Northern Hemisphere. We show that the “eddy feedback parameter” (EFP) used in previous studies is sensitive to sampling and multidecadal variability. When these uncertainties are accounted for, the EFP diagnosed from CMIP6 historical simulations generally falls within the reanalysis uncertainty. We find the EFP is not independent of the sampled North Atlantic Oscillation (NAO). Within the same dataset, a sample containing larger NAO variability will show a larger EFP, suggesting that the link between eddy feedbacks and the signal‐to‐noise paradox could be due to sampling effects with the EFP. An alternative measure of eddy feedback, the barotropic energy generation rate, is less sensitive to sampling errors and delineates CMIP6 models that have weak, strong, or unbiased eddy feedbacks, but shows little relation to NAO variability.
The Spread of the Hunga Tonga H2O Plume in the Middle Atmosphere Over the First Two Years Since Eruption
Authors: Nedoluha Gerald E. , Gomez R. Michael , Boyd Ian , Neal Helen , Allen Douglas R. , Lambert Alyn 
Published: June 2024

AbstractThe eruption of Hunga in January 2022 injected a large amount of water into the stratosphere. Satellite measurements from Aura Microwave Limb Sounder (MLS) show that this water vapor (H2O) has now spread throughout the stratosphere and into the lower mesosphere, resulting in an increase of >1 ppmv throughout most of this region. Measurements from three ground‐based Water Vapor Millimeter Wave Spectrometer (WVMS) instruments and MLS are in good agreement, and show that in 2023 there was more H2O in the lower mesosphere than at any time since the WVMS measurements began in the 1990's. At Table Mountain, California all WVMS H2O measurements at 54 km since June 2023, and all of the measurements from Mauna Loa, Hawaii, since the resumption of measurements in September 2023, show larger mixing ratios than any previous measurements. At 70 km several recent WVMS retrievals since September 2023 show the largest anomalies ever measured. The MLS measurements show that maximum H2O anomalies over the 2004–2023 record have occurred throughout almost all of the stratosphere and lower mesosphere since the eruption. As of November 2023, almost all of the ∼140 Tg of water originally injected into the stratosphere by the Hunga eruption remains in the middle atmosphere at pressures below 83 hPa (altitudes above ∼17 km). The eruption occurred during a period when stratospheric H2O was already slightly elevated above the 2004–2021 MLS average, and the November 2023 anomaly of ∼160 Tg represents ∼15% of the total mass of H2O in this region.
Pyroptosis and mitochondrial function participated in miR-654-3p-protected against myocardial infarction
Authors: Wu Chan , Zhang Xiao-Cheng , Chen Lan-Ruo , Huang Hui-Zhu , Wu Wei-Yin , Wang Yan , Li Gang 
Published: June 2024

AbstractMyocardial infarction (MI) is one of the leading causes of heart failure with highly complicated pathogeneses. miR-654-3p has been recognized as a pivotal regulator of controlling cell survival. However, the function of miR-654-3p in cardiomyocytes and MI has yet to be reported. This study aimed to identify the role of miR-654-3p in the regulation of myocardial infarction. To understand the contribution of miR-654-3p on heart function, we generated cardiac-specific knockdown and overexpression mice using AAV9 technology in MI injury. Mechanically, we combined cellular and molecular techniques, pharmaceutical treatment, RNA sequencing, and functional testing to elucidate the potential pathological mechanisms. We identified that mice subjected to MI decreased the expression of miR-654-3p in the border and infarcted area. Mice lacking miR-654-3p in the heart showed some inflammation infiltration and myocardial fibrosis, resulting in a mild cardiac injury. Furthermore, we found a deficiency of miR-654-3p in cardiomyocytes resulted in pyroptotic cell death but not other programmed cell death. Intriguingly, miR-654-3p deficiency aggravated MI-induced cardiac dysfunction, accompanied by higher myocardial fibrosis and cardiac enzymes and augmented pyroptosis activation. Cardiac elevating miR-654-3p prevented myocardial fibrosis and inflammation infiltration and decreased pyroptosis profile, thereby attenuating MI-induced cardiac damage. Using RNA sequence and molecular biological approaches, we found overexpression of miR-654-3p in the heart promoted the metabolic ability of the cardiomyocytes by promoting mitochondrial metabolism and mitochondrial respiration function. Our finding identified the character of miR-654-3p in protecting against MI damage by mediating pyroptosis and mitochondrial metabolism. These findings provide a new mechanism for miR-654-3p involvement in the pathogenesis of MI and reveal novel therapeutic targets.
Global groundwater warming due to climate change
Authors: Benz Susanne A. , Irvine Dylan J. , Rau Gabriel C. , Bayer Peter , Menberg Kathrin , Blum Philipp , Jamieson Rob C. , Griebler Christian , Kurylyk Barret L. 
Published: June 2024

AbstractAquifers contain the largest store of unfrozen freshwater, making groundwater critical for life on Earth. Surprisingly little is known about how groundwater responds to surface warming across spatial and temporal scales. Focusing on diffusive heat transport, we simulate current and projected groundwater temperatures at the global scale. We show that groundwater at the depth of the water table (excluding permafrost regions) is conservatively projected to warm on average by 2.1 °C between 2000 and 2100 under a medium emissions pathway. However, regional shallow groundwater warming patterns vary substantially due to spatial variability in climate change and water table depth. The lowest rates are projected in mountain regions such as the Andes or the Rocky Mountains. We illustrate that increasing groundwater temperatures influences stream thermal regimes, groundwater-dependent ecosystems, aquatic biogeochemical processes, groundwater quality and the geothermal potential. Results indicate that by 2100 following a medium emissions pathway, between 77 million and 188 million people are projected to live in areas where groundwater exceeds the highest threshold for drinking water temperatures set by any country.
Harmonizing existing climate change mitigation policy datasets with a hybrid machine learning approach
Authors: Wu Libo , Huang Zhihao , Zhang Xing , Wang Yushi 
Published: June 2024

AbstractWith the rapid proliferation of climate policies in both number and scope, there is an increasing demand for a global-level dataset that provides multi-indicator information on policy elements and their implementation contexts. To address this need, we developed the Global Climate Change Mitigation Policy Dataset (GCCMPD) using a semisupervised hybrid machine learning approach, drawing upon policy information from global, regional, and sector-specific sources. Differing from existing climate policy datasets, the GCCMPD covers a large range of policies, amounting to 73,625 policies of 216 entities. Through the integration of expert knowledge-based dictionary mapping, probability statistics methods, and advanced natural language processing technology, the GCCMPD offers detailed classification of multiple indicators and consistent information on sectoral policy instruments. This includes insights into objectives, target sectors, instruments, legal compulsion, administrative entities, etc. By aligning with the sector classification of the Intergovernmental Panel on Climate Change (IPCC) emission datasets, the GCCMPD serves to help policy-makers, researchers, and social organizations gain a deeper understanding of the similarities and distinctions among climate activities across countries, sectors, and entities.