bluuebunny/crossref_metadata_2025_split huggingface dataset:
Obesity and Smoking are causal factors for meniscal injury: A mendelian randomization study
Authors: He Bin , Hou Zhiao , Wang Zicheng , Deng Qiu , Chen Ji , Xiang Tao , Xiao Hong , Ouyang Hanbin 
Published: May 2024

Abstract

Background Previous observational studies have indicated a potential link between obesity, smoking, and meniscal injury. However, it is important to note that these studies are vulnerable to reverse causation and residual confounding. Therefore, the purpose of this study was to examine the causal estimates regarding the impact of these risk factors on meniscal injury. Methods In this study, single nucleotide polymorphisms associated with obesity and smoking were extracted as instrumental variables from the Gene-Wide Association Study database (GWAS). Data on genetic variants of meniscal injuries were obtained from the Finnish database. Heterogeneity of the data was assessed using IVW, MR-Egger and Cochran's Q statistics. Potential causality was assessed using inverse variance weighting, Mendelian randomisation Egger, and weighted median methods. Results Our study showed that obesity and smoking were causal factors for meniscal injuries. (Waist circumference: IVW: OR = 1.59; 95%CI = 1.41–1.80; P<0.001. Hip circumference: IVW: OR = 1.37; 95%CI = 1.23–1.53; P<0.001. BMI: IVW: OR = 1.53; 95%CI = 1.39–1.68; P<0.001. Smoking initiation: IVW: OR = 1.17; 95%CI = 1.00-1.37; P = 0.04. Current smoking: IVW: OR = 2.35; 95%CI = 1.18–4.66; P = 0.01. Past smoking: IVW: OR = 0.75; 95%CI = 0.62–0.90; P<0.01). Conclusion Our results enriched findings from previous epidemiology studies and provided evidence from MR that obesity and smoking have a clear causal effect on meniscal injuries.
Acute pyelonephritis in adults. Should we adopt the pediatric guidelines?
Authors: Neeman Binyamin B , Kafka Ilan , Mamber Ariel , Natsheh Ala Eldin , Koulikov Dmitry , Jaber jawdat , Chertin Boris 
Published: May 2024

Abstract

Purpose
There are no guidelines, what recommend pro or against CEVUS or VCUG for identification of VUR for adults who suffer from first episode of pyelonephritis. The aim of this study was to look at incidence of VUR in adults with first episode of pyelonephritis, and to highlight the necessity for recommending an investigation into reflux among these patients.
Methods
Retrospective study of all patients who admitted at our department in the past decade with the working diagnosis of pyelonephritis. Following discharge from the department, individuals with no pre-existing urological history were advised to undergo a VCUG or CEVUS to identify VUR.
Results
We have identified 76 patients (62 females and 14 males) with an average age of 31.73 years. 48(63%) presented with right pyelonephritis, 26(34%) with left and 2(3%) had bilateral disease. Of those, 23(30%) patients returned for clinical follow-up after completion of VCUG/CEVUS. Reflux was demonstrated in 14 (60%) patients comprising 18 renal refluxing units (RRU). 6 had grade IV reflux, 4 grade III, 4 grade II and 4 grade I respectively. DMSA demonstrated 27.2%±11.9% relative function of the reflux kidney. Of those VUR patients, 9 (64%) underwent endoscopic correction, one (7%) refused surgery and 4 (29%) are under clinical follow-up.
Conclusions
Our data demonstrate high incidence of VUR in these patients, therefore VUR investigation at least should be considered in adult patients even after first episode of pyelonephritis, especially in cases where there is evidence of nephronia, abscess, kidney scars, atrophic kidney or hydronephrosis.
Camphorsulfonic Acid-Catalyzed Synthesis of a Series of 2-Aryl/heteroaryl/alkyl-1H-anthra[
1,2-d]imidazole-6,11-dione Derivatives
Authors: Banerjee Bubun , Priya Anu , Singh Arvind , Sharma Aditi , Kaur Manmeet , Biswas Kinkar 
Published: May 2024

Abstract:
Anthraquinone moiety is very common among naturally occurring bioactive
compounds. Many commercially available drug molecules also possess anthraquinone
moiety. In recent times, among many other anthraquinone derivatives, specifically, 2-
substituted-1H-anthra[1,2-d]imidazole-6,11-diones are gaining extra attention due to their
significant anti-cancer, anti-HIV, anti-inflammatory activities, etc. This study aimed to report
a simple, straightforward, organocatalyzed method for the efficient synthesis of a series
of 2-aryl/heteroaryl/alkyl-1H-anthra[1,2-d]imidazole-6,11-diones from the reactions of
1,2-diaminoanthraquinone and various aldehydes using a catalytic amount of camphorsulfonic
acid as an efficient organocatalyst in aqueous ethanol under refluxed conditions. Under
the same optimized reaction conditions, along with aryl or heteroaryl aldehydes, aliphatic
aldehydes also underwent a smooth reaction and afforded the desired products in excellent yields. All
the synthesized compounds were obtained pure in excellent yields by simple filtration and washing subsequently
with ethanol. The use of less toxic solvent, low-cost, commercially available metal-free organocatalyst, no
column chromatographic separation, good yields, and easy isolation procedure are some of the major advantages
of this newly developed protocol.
Experiences of Caregivers in Disclosing HIV Status to Children Infected with HIV in Mopani District, South Africa
Authors: Nathaniel Muditambi Nndavheleseni , M Pamela Mamogobo , Takalani Mutshatshi E 
Published: May 2024

Background
Caregivers are confronted with difficulties in determining the ideal period to initiate HIV disclosure to the child infected with HIV. Moreover, caregivers are uncertain about how to facilitate the HIV disclosure process, and opportunities to start the discussion are frequently missed until a later stage. Caregivers often fear that the child will be affected psychologically and have poor cognitive ability to comprehend the nature of the illness.

Objective
The objective of the study is to explore and describe the experiences of primary caregivers regarding HIV disclosure to children infected with HIV.

Methods
A qualitative, explorative, and descriptive study was conducted at 4 selected ART facilities in the Mopani district. Where face-to-face semi-structured interviews were conducted until data saturation with 16 primary caregivers. Data was analysed and coded using the ATLAS.ti 9 program, according to the thematic method of analysis.

Results
Analysis of data identified three main themes that described the experience of caregivers regarding HIV disclosure in children, which are cues to disclose HIV status to children, experiences of the event of HIV status disclosure to children, and caregiver’s experiences of healthcare providers’ role in HIV disclosure process.

Conclusion
Caregivers revealed that they initiated the HIV disclosure process to the children because of their personal and child-related factors. However, they perceived HIV disclosure as a difficult process to initiate, because of lack of skills, knowledge, and support from healthcare providers. Caregivers perceived children as too young to receive HIV disclosure information and they feared that the child would react negatively.
Associated Factors of Loneliness Among Adolescents in Indonesia during the Pandemic of Covid-19
Authors: Panggaribuan Santa Maria , Yemina Loritta , Widiastuti Sri Hunun , Purborini Nurul , Casman Casman 
Published: May 2024

Outbreak of Corona virus disease (Covid) in 2020 affected people’s life, particularly adolescents. Loneliness was one of the problems that adolescents faced during the outbreak of Covid-19. Loneliness could affect adolescents health, both mental and physical health. On the other hands, there were a lot of factors that related to loneliness among adolescents. Therefore, the purpose of this study was to explore the factors associated with loneliness in adolescents in Indonesia during the Covid-19 pandemic. Methodology this study was a cross-sectional study. The respondents in this study were 590 adolescents. This study was using some questionnaires that distributed online by social media. The questionnaire included the Connor Davidson Resilience Scale (CD-RISC)-25, the UCLA loneliness Scale version 3, and demographic characteristics. Hierarchical linear regression was performed to investigate the determinant factors of loneliness among adolescents. Results this current study found that age group of 16-19 YO (β = .117); female adolescents (β = .095); trust in one’s instincts, tolerance to negative affect, and strengthening effects of stress (β = .130); and spiritual influence (β = .094) were associated with increasing loneliness in adolescents. For the positive acceptance of change, and secure relationship (β = -.289); and control (β = -.273) were associated with lower likelihood of having loneliness. Conclusion this current study found that age group of 16-19 YO; female adolescents; trust in one’s instincts, tolerance to negative affect, and strengthening effects of stress; and spiritual influence were associated with increasing loneliness in adolescents. For the positive acceptance of change, and secure relationship; and control were associated with lower likelihood of having loneliness. The current results, particularly the identification of associated factors, should be useful for developing loneliness-prevention program.
Cartography as a tool to analyze city planning and development
Authors: Chen Wanxu 
Published: May 2024

City planning is becoming more and more crucial as modernization and urbanization progress quickly. Making maps is an essential and helpful way in the city planning process for gathering data about the layout of a city and its elements, including the roads, traffic, buildings, and environment. Thanks to advancements in technology, computer software is now used to create maps, yielding more accurate and varied results. As a result, cartography is now closely related to and plays a crucial part in city planning. This brief essay will discuss the value of cartography in urban development and planning, as well as the connection between the two.
Impact of transcription factors KLF1 and GATA1 on red blood cell antigen expression: a review
Authors: Lopez Genghis H. , Sarri Mia E. , Flower Robert L. , Hyland Catherine A. 
Published: May 2024

Abstract
KLF transcription factor 1 (KLF1) and GATA binding protein 1 (GATA1) are transcription factors (TFs) that initiate and regulate transcription of the genes involved in erythropoiesis. These TFs possess DNA-binding domains that recognize specific nucleotide sequences in genes, to which they bind and regulate transcription. Variants in the genes that encode either KLF1 or GATA1 can result in a range of hematologic phenotypes—from benign to severe forms of thrombocytopenia and anemia; they can also weaken the expression of blood group antigens. The Lutheran (LU) blood group system is susceptible to TF gene variations, particularly KLF1 variants. Individuals heterozygous for KLF1 gene variants show reduced Lutheran antigens on red blood cells that are not usually detected by routine hemagglutination methods. This reduced antigen expression is referred to as the In(Lu) phenotype. For accurate blood typing, it is important to distinguish between the In(Lu) phenotype, which has very weak antigen expression, and the true Lunull phenotype, which has no antigen expression. The International Society of Blood Transfusion blood group allele database registers KLF1 and GATA1 variants associated with modified Lutheran expression. Here, we review KLF1 and recent novel gene variants defined through investigating blood group phenotype and genotype discrepancies or, for one report, investigating cases with unexplained chronic anemia. In addition, we include a review of the GATA1 TF, including a case report describing the second GATA1 variant associated with a serologic Lu(a–b–) phenotype. Finally, we review both past and recent reports on variations in the DNA sequence motifs on the blood group genes that disrupt the binding of the GATA1 TF and either remove or reduce erythroid antigen expression. This review highlights the diversity and complexity of the transcription process itself and the need to consider these factors as an added component for accurate blood group phenotyping.
Comprehensive ultrasound assessment of the state complex intima-media brachiocephalic arteries in patients with metabolic syndrome
Authors: Vakhitova Aliya R. , Berdalin Alexander B. , Lelyuk Vladimir G. , Lelyuk Svetlana E. 
Published: May 2024

Objective. Comprehensive ultrasound assessment of the state complex intima-media (CIM) of brachiocephalic arteries in patients with metabolic syndrome (MS). Materials and methods. 82 patients were examined, including 62 patients with MS and 20 practically healthy individuals. All patients underwent biochemical blood analysis, ultrasound of the extracranial sections of the brachiocephalic arteries with an assessment of the qualitative and quantitative characteristics of CIM bifurcation of the brachiocephalic trunk (BCT), common carotid arteries (CCA) and vertebral arteries (VA).Results. 100% of patients with MS, changes in the echostructure of CIM were recorded in the form of pathological layering, 9 (14.5%) patients – in the form of hyperechogenic inclusions. Thickness of CIM in the bifurcation of BCT and CCA in patients with MS statistically significantly exceeds the same indicator in practically healthy persons and demonstrates direct correlation between the components of MS. The modified Carnegan index patients with MS is statistically significantly higher than the same indicator in practically healthy individuals and demonstrates direct correlation with the thickness of CIM estimated in different segments of the brachiocephalic arteries (BCT k 0.356, RCCA k 0.718, LCCA k 0.846, in the bifurcation of CCA on the right k 0.431, on the left k 0.519).Conclusion. Comprehensive ultrasound assessment of the state brachiocephalic arteries in patients with MS allows us to obtain complex of qualitative and quantitative signs characteristic of metabolic angiopathy.
Echographic pattern features of dissections of the extracranial parts of the brachiocephalic arteries
Authors: Orlova Ekaterina V. , Berdalin Alexander B. , Khaitsman Darya M. , Lelyuk Vladimir G. , Lelyuk Svetlana E. 
Published: May 2024

Purpose: to determine the frequency of various ultrasound signs of dissections of the extracranial parts of the brachiocephalic arteries, as well as to compare the results of ultrasound and neuroimaging methods in the diagnostics of dissections.Materials and methods. The study included data on 108 patients, among them 44 (40.7%) women, 64 (59.3%) men, mean age was 56 ± 14 years. All patients underwent duplex scanning of the brachiocephalic arteries, 53 patients underwent CT-angiography, and 99 patients underwent MRI.Results. The sensitivity of duplex scanning in the primary diagnosis of dissections in our study was 97.2%. In 40 patients (37%) with dissections according to duplex scanning the presence of dissection was also confirmed on CT-angiography or MRI. Expansion of the vessel diameter and the presence of intramural hematoma (IMH), as well as their combination, were the most common ultrasound signs of dissections in our study. In cases where dissection was not confirmed by CT-angiography or MRI data moderate echogenicity of IMH was noted significantly more often (p = 0.018). Of all the ultrasound signs of dissections, the highest share of coincidence with the signs obtained with neuroimaging diagnostic methods occurred with IMG.Conclusion. The most frequently recorded ultrasound signs of dissections were the expansion of the vessel diameter and the presence of IMG, as well as their combination. The results of the study showed a high sensitivity of the ultrasound method in detecting dissections, especially in the subacute and chronic stages, as well as to determine the causes of ischemic stroke in the differential diagnosis of brachiocephalic artery pathologies.
Liver non-contrast perfusion in diffuse liver diseases diagnostic algorithm: the new diagnostic criteria
Authors: Telesh A. A. , Morozova T. G. 
Published: May 2024

Purpose: to define the new criteria for contrast-free ASL perfusion using for the management of diffuse liver diseases (DLD).Material and methods. Clinical and laboratory data, results of MRI with non-contrast MR perfusion (ASL-perfusion) of the liver were estimated in a group of patients with DLD (three-year research).Results. Potentials of assessment of liver ASL perfusion for patients with DLD (including complicated cases) are described in the article. It was established that ASL liver perfusion is useful for DLD clinical forms differential diagnosis, predicting the risk of liver cirrhosis, as well as complications (hepatic encephalopathy, sialoadenitis) and DLD exacerbation. The strategy of contrast-free MR perfusion using in patients with DLD management algorithm was developed.Conclusion. Liver ASL perfusion is a promising for the study and application method for the management of DLD.
The influence of modern computer and magnetic resonance imaging technologies on the preoperative staging of pancreatic cancer
Authors: Zharikova Alexandra V. , Kondratyev Evgeny V. , Tikhonova Valeriya S. , Gruzdev Ivan S. , Rostovtsev Mikhail V. , Markov Pavel V. , Struchkov Vladimir Yu. , Karmazanovsky Grigory G. 
Published: May 2024

Цель исследования: обзор и анализ зарубежной и отечественной литературы, клинических рекомендаций, посвященных оценке распространенности опухоли протоковой аденокарциномы поджелудочной железы и тактике лечения пациентов с выявленным новообразованием поджелудочной железы.Материал и методы. Проведен анализ отечественных и зарубежных источников литературы по базам PubMed с использованием ключевых слов “pancreatic cancer”, “vascular invasion”, “locally advanced cancer”, “cancer statistics”, “CT”, “MRI”, “neoadjuvant therapy” за последние 5–10 лет.В данном обзоре рассмотрены основные методы визуализации, используемые для определения взаимоотношения опухоли с прилежащими магистральными сосудами и оценки резектабельности рака поджелудочной железы.Заключение. Компьютерная томография и магнитно-резонансная томография с контрастным усилением – первоочередные методы диагностики протоковой аденокарциномы поджелудочной железы. Они высокоинформативны для оценки контакта/вовлечения сосудистых структур, распространенности опухолевого процесса, однако стандартные критерии неинформативны для оценки ответа на химиотерапевтическое лечение, поэтому требуется внедрение альтернативных способов его оценки, одним из которых является радиомика, лежащая в основе работы искусственного интеллекта и программ глубокого машинного обучения.
Exploring Resilience as a Mediator Between Charismatic Leadership and Affective Commitment to Change
Authors: Mangundjaya Wustari L. , Supriyadi Tugimin , Nugraha Andreas Corsini Widya , Wicaksana Seta Ariawuri 
Published: May 2024

Objective: The purpose of this study is to measure the effects of charismatic leadership on change initiatives (affective commitment to change), mediated by resilience.

Method: Data was collected using the Affective Commitment Inventory. Charismatic leadership scales (Conger & Kanungo, and Resilience inventory) using Structural Equation Modelling. This study surveyed 355 employees in the banking and insurance industry.

Results Finding and Discussion: The results showed that charismatic leadership positively affected affective commitment to change directly and by resilience as a partial mediator. It is also demonstrated that the results added to the body of knowledge and theory concerning the function and adaptability of charismatic leaders in change initiatives and change management procedures.

Research Implications: The results contribute to the organization in terms of developing the change agent with a style of charismatic leadership to develop an affective commitment to change.

Originality/Value: The research offers about manage organizational change, especially to manage the strategic position of leaders as How to be a change agent. To create an affective commitment, change leaders must adopt the characteristics of charismatic leaders, including unconventional behavior, innovative and unique activities, and sensitivity to their followers.
Green Practice Motivation in Small Businesses
Authors: Lestari Dwi Indah , Vasudevan Asokan , AdialitaC Tania , Rungsuk Anong 
Published: May 2024

Purpose: The study's primary aim is to identify and analyze the factors influencing the motivation of Small and Medium Enterprises (SMEs) in Indonesia to implement green accounting practices as part of sustainable business operations.

Theoretical framework: The theoretical framework focuses on motivational theories, particularly distinguishing between extrinsic and intrinsic motivations. This framework underpins the study's exploration of why SMEs might adopt green practices.

Method: The research employs a deductive approach, utilizing qualitative methods such as interviews and document analysis to gather data. This approach is used to understand the motivations behind SMEs' decisions to implement green accounting practices.

Result and Conclusion: The study finds that extrinsic and intrinsic factors motivate SMEs to run sustainable businesses and adopt green accounting practices. Extrinsic motivations include introjected motivation, identification, and integrated motivation, while intrinsic motivations are derived from satisfaction, profits, and cost efficiency.

Research implications: The study contributes to the broader understanding of green practices in the context of SMEs, a sector often overlooked in previous research predominantly focused on larger companies. The findings can aid SMEs in understanding the various motivational factors that could drive the adoption of green practices. The results are valuable for policy-making, providing insights for the government to develop green policies tailored to small businesses, promoting broader environmental sustainability within the business sector.

Originality/value: This study focuses on green accounting that was carried out in a small, medium enterprises (SMEs) context, which has not been studied much by previous studies.
A Case of Refractory Cutaneous Sarcoidosis Successfully Treated with Infliximab
Authors: Al-Dehneem Roudha 
Published: May 2024

Sarcoidosis is an inflammatory granulomatous disease affecting multiple organs with cutaneous sarcoidosis occurring in 25% of patients. There are several treatment options available, but alternative therapies should be considered in patients with refractory disease to standard intervention. Though they are not been FDA-approved for sarcoidosis, TNF-a inhibitors have demonstrated significant therapeutic intervention targeting proinflammatory cytokines involves in pathogenesis of sarcoidosis. Herein, we present a case of refractory cutaneous sarcoidosis successfully treated with infliximab therapy with significant hair regrowth on the scalp.
THE EFFECT OF TAX KNOWLEDGE, TAXATION SYSTEM MODERNIZATIONON MSME TAXPAYER COMPLIANCE IN BANDUNG CITY
Authors: Mardini Riyang 
Published: May 2024

One of the main challenges for the government in managing state finances today is the low state revenue from the tax sector. This study aims to develop a conceptual framework of tax knowledge and modernization of the taxation system that can be used to analyze and discuss it as a factor that affects tax compliance. This study uses a purposive sampling technique based on the population of MSMEs in the food and beverage sector in Bandung, Indonesia. The analytical method used is multiple linear regression with SPSS 24. The results show that knowledge of taxation and modernization of the taxation system has a significant effect either, partially or simultaneously.
Keywords : Knowledge of taxation, Modernization of the taxation system, taxpayer compliance.