bluuebunny/crossref_metadata_2025_split huggingface dataset:
The E3 Ubiquitin Ligase Activity Associated with the Adenoviral E1B-55K–E4orf6 Complex Does Not Require CRM1-Dependent Export
Authors: Schmid Melanie , Kindsmüller Kathrin , Wimmer Peter , Groitl Peter , Gonzalez Ramon A. , Dobner Thomas 
Published: May 2011

ABSTRACT
The adenovirus type 5 (Ad5) E1B-55K and E4orf6 (E1B-55K/E4orf6) proteins are multifunctional regulators of Ad5 replication, participating in many processes required for virus growth. A complex containing the two proteins mediates the degradation of cellular proteins through assembly of an E3 ubiquitin ligase and induces shutoff of host cell protein synthesis through selective nucleocytoplasmic viral late mRNA export. Both proteins shuttle between the nuclear and cytoplasmic compartments via leucine-rich nuclear export signals (NES). However, the role of their NES-dependent export in viral replication has not been established. It was initially shown that mutations in the E4orf6 NES negatively affect viral late gene expression in transfection/infection complementation assays, suggesting that E1B-55K/E4orf6-dependent viral late mRNA export involves a CRM1 export pathway. However, a different conclusion was drawn from similar studies showing that E1B-55K/E4orf6 promote late gene expression without active CRM1 or functional NES. To evaluate the role of the E1B-55K/E4orf6 NES in viral replication in the context of Ad-infected cells and in the presence of functional CRM1, we generated virus mutants carrying amino acid exchanges in the NES of either or both proteins. Phenotypic analyses revealed that mutations in the NES of E1B-55K and/or E4orf6 had no or only moderate effects on viral DNA replication, viral late protein synthesis, or viral late mRNA export. Significantly, such mutations also did not interfere with the degradation of cellular substrates, indicating that the NES of E1B-55K or E4orf6 is dispensable both for late gene expression and for the activity associated with the E3 ubiquitin ligase.
X-configuration intersecting Enterprise stents for vascular remodeling and assisted coil embolization of a wide neck anterior communicating artery aneurysm
Authors: Lazzaro Marc A , Zaidat Osama O 
Published: May 2011

BackgroundIntracranial stent technology and techniques have expanded the applications of endovascular therapy for complex intracranial aneurysms. Various methods of stent assisted coil embolization have been described. An additional technique of X-configuration intersecting Enterprise stent implantation with trans-stent microcatheterization for the treatment of a wide neck anterior communicating artery aneurysm is presented.ResultsSuccessful X-configuration intersecting stent implantation and coil embolization of a wide neck aneurysm is reported with no perioperative complications.ConclusionsThe technique of trans-stent microcatheterization with X-configuration intersecting Enterprise stent implantation for the treatment of wide neck anterior communicating artery aneurysms is technically feasible. Further study is needed to evaluate technical success, procedural outcome and long term angiographic results.
EQUIVARIANT COLORED 𝔰𝔩(N)-HOMOLOGY FOR LINKS
Authors: WU HAO 
Published: May 2011

In this sequel to [A colored 𝔰𝔩(N)-homology for links in S3, preprint (2009), arXiv:0907.0695v5], we construct an equivariant colored 𝔰𝔩(N)-homology for links, which generalizes both the above mentioned paper and the paper by [D. Krasner, Equivariant sl(n)-link homology, preprint (2008), arXiv:0804.3751v2]. The construction is a straightforward generalization of the paper, [A colored 𝔰𝔩(N)-homology for links in S3]. The proof of invariance is based on a simple observation which allows us to translate the proof in the above mentioned paper into the new setting. As an application, we prove that deformations over ℂ of the colored 𝔰𝔩(N)-homology are link invariants. We also construct a spectral sequence connecting the colored 𝔰𝔩(N)-homology to its deformations over ℂ, which generalizes the spectral sequence given in the papers by [B. Gornik, Note on Khovanov link cohomology, preprint (2004), arXiv:math.QA/0402266 and E. Lee, An endomorphism of the Khovanov invariant, Adv. Math.197(2) (2005) 554–586].
MINIMUM NUMBER OF FOX COLORS FOR SMALL PRIMES
Authors: LOPES PEDRO , MATIAS JOÃO 
Published: May 2011

This article concerns exact results on the minimum number of colors of a Fox coloring over the integers modulo r, of a link with non-null determinant.Specifically, we prove that whenever the least prime divisor of the determinant of such a link and the modulus r is 2, 3, 5, or 7, then the minimum number of colors is 2, 3, 4, or 4 (respectively) and conversely.We are thus led to conjecture that for each prime p there exists a unique positive integer, mp, with the following property. For any link L of non-null determinant and any modulus r such that p is the least prime divisor of the determinant of L and the modulus r, the minimum number of colors of L modulo r is mp.
BIORTHOGONAL WAVELETS WITH SIX-FOLD AXIAL SYMMETRY FOR HEXAGONAL DATA AND TRIANGLE SURFACE MULTIRESOLUTION PROCESSING
Authors: JIANG QINGTANG 
Published: May 2011

This paper discusses the construction of highly symmetric compactly supported wavelets for hexagonal data/image and triangle surface multiresolution processing. Recently, hexagonal image processing has attracted attention. Compared with the conventional square lattice, the hexagonal lattice has several advantages, including that it has higher symmetry. It is desirable that the filter banks for hexagonal data also have high symmetry which is pertinent to the symmetric structure of the hexagonal lattice. The high symmetry of filter banks and wavelets not only leads to simpler algorithms and efficient computations, it also has the potential application for the texture segmentation of hexagonal data. While in the field of computer-aided geometric design (CAGD), when the filter banks are used for surface multiresolution processing, it is required that the corresponding decomposition and reconstruction algorithms for regular vertices have high symmetry, which make it possible to design the corresponding multiresolution algorithms for extraordinary vertices. In this paper we study the construction of six-fold axial symmetric biorthogonal filter banks and the associated wavelets, with both the dyadic and [Formula: see text]-refinements. The constructed filter banks have the desirable symmetry for hexagonal data processing. By associating the outputs (after one-level multiresolution decomposition) appropriately with the nodes of the regular triangular mesh with which the input data is associated (sampled), we represent multiresolution analysis and synthesis algorithms as templates. The six-fold axial symmetric filter banks constructed in this paper result in algorithm templates with desirable symmetry for triangle surface processing.
WEE1 Kinase Targeting Combined with DNA-Damaging Cancer Therapy Catalyzes Mitotic Catastrophe
Authors: De Witt Hamer Philip C. , Mir Shahryar E. , Noske David , Van Noorden Cornelis J.F. , Würdinger Tom 
Published: May 2011

AbstractWEE1 kinase is a key molecule in maintaining G2–cell-cycle checkpoint arrest for premitotic DNA repair. Whereas normal cells repair damaged DNA during G1-arrest, cancer cells often have a deficient G1-arrest and largely depend on G2-arrest. The molecular switch for the G2–M transition is held by WEE1 and is pushed forward by CDC25. WEE1 is overexpressed in various cancer types, including glioblastoma and breast cancer. Preclinical studies with cancer cell lines and animal models showed decreased cancer cell viability, reduced tumor burden, and improved survival after WEE1 inhibition by siRNA or small molecule inhibitors, which is enhanced by combination with conventional DNA-damaging therapy, such as radiotherapy and/or cytostatics. Mitotic catastrophe results from premature entry into mitosis with unrepaired lethal DNA damage. As such, cancer cells become sensitized to conventional therapy by WEE1 inhibition, in particular those with insufficient G1-arrest due to deficient p53 signaling, like glioblastoma cells. One WEE1 inhibitor has now reached clinical phase I studies. Dose-limiting toxicity consisted of hematologic events, nausea and/or vomiting, and fatigue. The combination of DNA-damaging cancer therapy with WEE1 inhibition seems to be a rational approach to push cancer cells in mitotic catastrophe. Its safety and efficacy are being evaluated in clinical studies. Clin Cancer Res; 17(13); 4200–7. ©2011 AACR.
The Temporal Dynamics of Object Processing in Visual Cortex during the Transition from Distributed to Focused Spatial Attention
Authors: Wu Chien-Te , Libertus Melissa E. , Meyerhoff Karen L. , Woldorff Marty G. 
Published: May 2011

Abstract
Several major cognitive neuroscience models have posited that focal spatial attention is required to integrate different features of an object to form a coherent perception of it within a complex visual scene. Although many behavioral studies have supported this view, some have suggested that complex perceptual discrimination can be performed even with substantially reduced focal spatial attention, calling into question the complexity of object representation that can be achieved without focused spatial attention. In the present study, we took a cognitive neuroscience approach to this problem by recording cognition-related brain activity both to help resolve the questions about the role of focal spatial attention in object categorization processes and to investigate the underlying neural mechanisms, focusing particularly on the temporal cascade of these attentional and perceptual processes in visual cortex. More specifically, we recorded electrical brain activity in humans engaged in a specially designed cued visual search paradigm to probe the object-related visual processing before and during the transition from distributed to focal spatial attention. The onset times of the color popout cueing information, indicating where within an object array the subject was to shift attention, was parametrically varied relative to the presentation of the array (i.e., either occurring simultaneously or being delayed by 50 or 100 msec). The electrophysiological results demonstrate that some levels of object-specific representation can be formed in parallel for multiple items across the visual field under spatially distributed attention, before focal spatial attention is allocated to any of them. The object discrimination process appears to be subsequently amplified as soon as focal spatial attention is directed to a specific location and object. This set of novel neurophysiological findings thus provides important new insights on fundamental issues that have been long-debated in cognitive neuroscience concerning both object-related processing and the role of attention.
The Interaction of Lexical Semantics and Cohort Competition in Spoken Word Recognition: An fMRI Study
Authors: Zhuang Jie , Randall Billi , Stamatakis Emmanuel A. , Marslen-Wilson William D. , Tyler Lorraine K. 
Published: May 2011

Abstract
Spoken word recognition involves the activation of multiple word candidates on the basis of the initial speech input—the “cohort”—and selection among these competitors. Selection may be driven primarily by bottom–up acoustic–phonetic inputs or it may be modulated by other aspects of lexical representation, such as a word's meaning [Marslen-Wilson, W. D. Functional parallelism in spoken word-recognition. Cognition, 25, 71–102, 1987]. We examined these potential interactions in an fMRI study by presenting participants with words and pseudowords for lexical decision. In a factorial design, we manipulated (a) cohort competition (high/low competitive cohorts which vary the number of competing word candidates) and (b) the word's semantic properties (high/low imageability). A previous behavioral study [Tyler, L. K., Voice, J. K., & Moss, H. E. The interaction of meaning and sound in spoken word recognition. Psychonomic Bulletin & Review, 7, 320–326, 2000] showed that imageability facilitated word recognition but only for words in high competition cohorts. Here we found greater activity in the left inferior frontal gyrus (BA 45, 47) and the right inferior frontal gyrus (BA 47) with increased cohort competition, an imageability effect in the left posterior middle temporal gyrus/angular gyrus (BA 39), and a significant interaction between imageability and cohort competition in the left posterior superior temporal gyrus/middle temporal gyrus (BA 21, 22). In words with high competition cohorts, high imageability words generated stronger activity than low imageability words, indicating a facilitatory role of imageability in a highly competitive cohort context. For words in low competition cohorts, there was no effect of imageability. These results support the behavioral data in showing that selection processes do not rely solely on bottom–up acoustic–phonetic cues but rather that the semantic properties of candidate words facilitate discrimination between competitors.
The Neural Basis of Parallel Saccade Programming: An fMRI Study
Authors: Hu Yanbo , Walker Robin 
Published: May 2011

Abstract
The neural basis of parallel saccade programming was examined in an event-related fMRI study using a variation of the double-step saccade paradigm. Two double-step conditions were used: one enabled the second saccade to be partially programmed in parallel with the first saccade while in a second condition both saccades had to be prepared serially. The intersaccadic interval, observed in the parallel programming (PP) condition, was significantly reduced compared with latency in the serial programming (SP) condition and also to the latency of single saccades in control conditions. The fMRI analysis revealed greater activity (BOLD response) in the frontal and parietal eye fields for the PP condition compared with the SP double-step condition and when compared with the single-saccade control conditions. By contrast, activity in the supplementary eye fields was greater for the double-step condition than the single-step condition but did not distinguish between the PP and SP requirements. The role of the frontal eye fields in PP may be related to the advanced temporal preparation and increased salience of the second saccade goal that may mediate activity in other downstream structures, such as the superior colliculus. The parietal lobes may be involved in the preparation for spatial remapping, which is required in double-step conditions. The supplementary eye fields appear to have a more general role in planning saccade sequences that may be related to error monitoring and the control over the execution of the correct sequence of responses.
Right Frontal Lobe Mediation of Recollection- and Familiarity-based Verbal Recognition Memory: Evidence from Patients with Tumor Resections
Authors: Anderson Nicole D. , Davidson Patrick S. R. , Mason Warren P. , Gao Fuqiang , Binns Malcolm A. , Winocur Gordon 
Published: May 2011

Abstract
Medial-temporal, parietal, and pFC regions have been implicated in recollection and familiarity, but existing evidence from neuroimaging and patient studies is limited and conflicting regarding the role of specific regions within pFC in these memory processes. We report a study of 20 patients who had undergone resection of right frontal lobe tumors and 20 matched healthy control participants. The location and extent of lesions were traced on the patients' scans. A process dissociation procedure was employed to yield estimates of the contributions of recollection and familiarity in verbal recognition performance. Group comparisons revealed deficits in recollection but not familiarity in the patient group relative to their healthy counterparts. We found a positive relationship between estimates of familiarity and lesion sizes in the right inferior pFC (BA 11, 47) which was significant upon bootstrap resampling. These results are discussed in terms of prior work linking this area to an overextended sense of familiarity.
Measuring Environmental Favorability for Tropical Cyclogenesis by Statistical Analysis of Threshold Parameters
Authors: McGauley Michael G. , Nolan David S. 
Published: May 2011

Abstract
As the climate changes, the ability to predict changes in the frequency of tropical cyclogenesis is becoming of increasing interest. A unique approach is proposed that utilizes threshold values in potential intensity, wind shear, vorticity, and normalized saturation deficit. Prior statistical methods generally involve creating an index or equation based on averages of important meteorological parameters for a given region. The new method assumes that threshold values exist for each important parameter for which cyclogenesis is unlikely to develop. This technique is distinct from previous approaches that seek to determine how each of these parameters interdependently favors cyclogenesis.
To determine three of the individual threshold values (shear, potential intensity, and vorticity), an idealized climate is first established that represents the most advantageous but realistic (MABR) environment. An initial numerical simulation of tropical cyclone genesis in the MABR environment confirms that it is highly favorable for cyclogenesis. Subsequent numerical simulations vary each parameter individually until no tropical cyclone develops, thereby determining the three threshold values. The new method of point downscaling, whereby background meteorological features are represented by a single vertical profile, is used in the simulations to greatly simplify the approach. The remaining threshold parameter (normalized saturation deficit) is determined by analyzing the climatological record and choosing a value that is statistically observed to prevent cyclogenesis. Once each threshold value is determined, the fraction of time each is exceeded in the location of interest is computed from the reanalysis dataset. The product of each fraction for each of the relevant parameters then gives a statistical probability as to the likelihood of cyclogenesis. For predicting regional and monthly variations in frequency of genesis, this approach is shown to generally meet or exceed the predictive skills of earlier statistical attempts with some failure only during several off-season months. This method also provides a more intuitive rationale of the results.
Projections of Future Drought in the Continental United States and Mexico
Authors: Wehner Michael , Easterling David R. , Lawrimore Jay H. , Heim Richard R. , Vose Russell S. , Santer Benjamin D. 
Published: May 2011

AbstractUsing the Palmer drought severity index, the ability of 19 state-of-the-art climate models to reproduce observed statistics of drought over North America is examined. It is found that correction of substantial biases in the models’ surface air temperature and precipitation fields is necessary. However, even after a bias correction, there are significant differences in the models’ ability to reproduce observations. Using metrics based on the ability to reproduce observed temporal and spatial patterns of drought, the relationship between model performance in simulating present-day drought characteristics and their differences in projections of future drought changes is investigated. It is found that all models project increases in future drought frequency and severity. However, using the metrics presented here to increase confidence in the multimodel projection is complicated by a correlation between models’ drought metric skill and climate sensitivity. The effect of this sampling error can be removed by changing how the projection is presented, from a projection based on a specific time interval to a projection based on a specified temperature change. This modified class of projections has reduced intermodel uncertainty and could be suitable for a wide range of climate change impacts projections.
Four-Dimensional Assimilation of Multitime Wind Profiles over a Single Station and Numerical Simulation of a Mesoscale Convective System Observed during IHOP_2002
Authors: Zhang Lei , Pu Zhaoxia 
Published: May 2011

Abstract
This study examines the impact of assimilating multitime wind profiles over a single station on the numerical simulation of a warm season mesoscale convective system over the region from the Kansas and Oklahoma border to the Texas Panhandle, observed 12–13 June 2002 during the International H2O Project (IHOP_2002). Wind profile observations, obtained from Goddard Lidar Observatory for Winds (GLOW) are assimilated into an advanced research version of the Weather Research and Forecasting (WRF) model using its four-dimensional variational data assimilation (4DVAR) system. Results indicate that the assimilation of high temporal and vertical resolution GLOW wind profiles has a significant influence on the numerical simulation of the convective initiation and evolution. Besides the wind fields, the structure of the moisture fields associated with the convective system is also improved. Data assimilation has also resulted in a more accurate prediction of the locations and timing of the convection initiations; as a consequence, the skill of quantitative precipitation forecasting is enhanced greatly.
The positive impact of 4DVAR assimilation of multitime wind profiles over a single station on the mesoscale prediction in this study presents a successful procession of the traditional technique in time to space conversion. However, when the data from conventional networks are assimilated into the model with GLOW wind profiles, the data impact is not compatible with that from the assimilation of GLOW wind profiles only, implying the need for a high temporal and spatial resolution wind profile network in order to achieve reasonable mesoscale analysis and forecasting.
Is patient autonomy a critical determinant of quality of life in Korea? End-of-life decision making from the perspective of the patient
Authors: Mo Ha Na , Shin Dong Wook , Woo Jae Ha , Choi Jin Young , Kang Jina , Baik Young Ji , Huh Yu Rae , Won Joo Hee , Park Myung Hee , Cho Sang Hee 
Published: May 2011

Purpose: We aimed to investigate the current practice of the involvement in decision making from the perspectives of terminal cancer patients, and to explore its possible associations with quality of life and quality of death in Korea. Methods: A multi-center, cross-sectional survey was performed on 93 terminal cancer patients. The questionnaire solicited their opinions regarding participation in treatment decision making, as well as quality of life (European Organization for Research and Treatment of Cancer Quality-of-Life Questionnaire for Palliative Care) and quality of death (Good Death Inventory-Patient Version). Results: A total of 78.5% of the patients had awareness of their terminal status, while 21.5% did not; 42.4% stated that they knew their condition and shared the decision-making responsibility with the medical staff and their family, while 21.7% made decisions on their own, and 35.9% left the decision-making responsibility to others. Patients who were aware of their illness and who actively participated in the decision making did not score higher than others on outcome measures of quality of life and quality of death. Moreover, the former even showed lower scores in some domains, including the ‘physical and psychological comfort’ (4.99 versus 5.61, p = 0.03), ‘environmental comfort’ (5.51 versus 6.04, p = 0.08), and ‘emotional functioning’ (55.70 versus 71.01, p = 0.06). Conclusion: in Korea, patient autonomy is not a universally accepted value from the perspectives of terminal cancer patients, nor is patient involvement in decision making always conducive to high quality of life or quality of death. The level of information and the pace at which it is provided should be tailored to each individual’s ability, preference, need, and culture.