bluuebunny/crossref_metadata_2025_split huggingface dataset:
Case-Case Genome-Wide Analyses Identify Subtype-Informative Variants That Confer Risk for Breast Cancer
Authors: Sun Xiaohui , Verma Shiv P. , Jia Guochong , Wang Xinjun , Ping Jie , Guo Xingyi , Shu Xiao-Ou , Chen Jianhong , Derkach Andriy , Cai Qiuyin , Liang Xiaolin , Long Jirong , Offit Kenneth , Oh Jung H. , Reiner Anne S. , Watt Gordon P. , Woods Meghan , Yang Yaohua , Ambrosone Christine B. , Ambs Stefan , Chen Yu , Concannon Patrick , Garcia-Closas Montserrat , Gu Jian , Haiman Christopher A. , Hu Jennifer J. , Huo Dezheng , John Esther M. , Knight Julia A. , Li Christopher I. , Lynch Charles F. , Mellemkjær Lene , Nathanson Katherine L. , Nemesure Barbara , Olopade Olufunmilayo I. , Olshan Andrew F. , Pal Tuya , Palmer Julie R. , Press Michael F. , Sanderson Maureen , Sandler Dale P. , Troester Melissa A. , Zheng Wei , Bernstein Jonine L. , Buas Matthew F. , Shu Xiang 
Published: June 2024

Abstract
Breast cancer includes several subtypes with distinct characteristic biological, pathologic, and clinical features. Elucidating subtype-specific genetic etiology could provide insights into the heterogeneity of breast cancer to facilitate the development of improved prevention and treatment approaches. In this study, we conducted pairwise case–case comparisons among five breast cancer subtypes by applying a case–case genome-wide association study (CC-GWAS) approach to summary statistics data of the Breast Cancer Association Consortium. The approach identified 13 statistically significant loci and eight suggestive loci, the majority of which were identified from comparisons between triple-negative breast cancer (TNBC) and luminal A breast cancer. Associations of lead variants in 12 loci remained statistically significant after accounting for previously reported breast cancer susceptibility variants, among which, two were genome-wide significant. Fine mapping implicated putative functional/causal variants and risk genes at several loci, e.g., 3q26.31/TNFSF10, 8q22.3/NACAP1/GRHL2, and 8q23.3/LINC00536/TRPS1, for TNBC as compared with luminal cancer. Functional investigation further identified rs16867605 at 8q22.3 as a SNP that modulates the enhancer activity of GRHL2. Subtype-informative polygenic risk scores (PRS) were derived, and patients with a high subtype-informative PRS had an up to two-fold increased risk of being diagnosed with TNBC instead of luminal cancers. The CC-GWAS PRS remained statistically significant after adjusting for TNBC PRS derived from traditional case–control GWAS in The Cancer Genome Atlas and the African Ancestry Breast Cancer Genetic Consortium. The CC-GWAS PRS was also associated with overall survival and disease-specific survival among patients with breast cancer. Overall, these findings have advanced our understanding of the genetic etiology of breast cancer subtypes, particularly for TNBC.
Significance: The discovery of subtype-informative genetic risk variants for breast cancer advances our understanding of the etiologic heterogeneity of breast cancer, which could accelerate the identification of targets and personalized strategies for prevention and treatment.
Advancing cryptography: a novel hybrid cipher design merging Feistel and SPN structures
Authors: Venkataramanna Ramya Kothur , Hosur Sriram Manjunatha Reddy , Reddy Bharathi Chowda 
Published: June 2024

In the dynamic field of cryptography, lightweight ciphers play a pivotal role in overcoming resource constraints in modern applications. This paper introduces a lightweight cryptographic algorithm by seamlessly merging the proven characteristics of the Feistel cipher CLEFIA with the advanced substitution-permutation network (SPN) framework of RECTANGLE for key generation. The algorithm incorporates a specially optimized feather S-box, balancing efficiency and security in both CLEFIA and RECTANGLE components. The RECTANGLE key generation, vital for the proposed lightweight technique, enhances overall cryptographic security and efficiency. Meticulous consideration of resource limitations maintains the algorithm's lightweight nature, making it well-suited for applications with restricted computational resources. To validate the efficacy of the lightweight algorithm, extensive evaluation on encrypted data is conducted using National Institute of Standards and Technology (NIST) tools, known for assessing cryptographic algorithm quality. Results reveal a high degree of randomness, indicative of robust resistance against cryptographic attacks. This manuscript provides a comprehensive examination of the lightweight algorithm, emphasizing key attributes, security enhancements, and successful integration of the optimized feather S-box. Rigorous testing, particularly NIST tool-based randomness analysis, offers empirical evidence of the algorithm's resilience against attacks, establishing its suitability for secure data encryption in resource-limited environments.<p> </p>
Antihypertensive Medication Use Trajectories After Bariatric Surgery: A Matched Cohort Study
Authors: Passman Jesse E. , Wall-Wieler Elizabeth , Liu Yuki , Zheng Feibi , Cohen Jordana B. 
Published: June 2024

BACKGROUND:
Metabolic and bariatric surgery (MBS) is the most effective and durable treatment for obesity. We aimed to compare the trajectories of antihypertensive medication (AHM) use among obese individuals treated and not treated with MBS.

METHODS:

Adults with a body mass index of ≥35 kg/m
2
were identified in the Merative Database (US employer-based claims database). Individuals treated with versus without MBS were matched 1:1 using baseline demographic and clinical characteristics as well as AHM utilization. Monthly AHM use was examined in the 3 years after the index date using generalized estimating equations. Subanalyses investigated rates of AHM discontinuation, AHM initiation, and apparent treatment-resistant hypertension.

RESULTS:

The primary cohort included 43 206 adults who underwent MBS matched with 43 206 who did not. Compared with no MBS, those treated with MBS had sustained, markedly lower rates of AHM use (31% versus 15% at 12 months; 32% versus 17% at 36 months). Among patients on AHM at baseline, 42% of patients treated with MBS versus 7% treated medically discontinued AHM use (
P
<0.01). The risk of apparent treatment-resistant hypertension was 3.41× higher (95% CI, 2.91–4.01;
P
<0.01) 2 years after the index date in patients who did not undergo MBS. Among those without hypertension treated with MBS versus no MBS, 7% versus 21% required AHM at 2 years.

CONCLUSIONS:
MBS is associated with lower rates of AHM use, higher rates of AHM discontinuation, and lower rates of AHM initiation among patients not taking AHM. These findings suggest that MBS is both an effective treatment and a preventative measure for hypertension.
Uncertainties Inherent from Large-Scale Climate Projections in the Statistical Downscaling Projection of North Atlantic Tropical Cyclone Activity
Authors: Xi Dazhi , Lin Ning , Jing Renzhi , Harr Patrick , Oppenheimer Michael 
Published: June 2024

Abstract
North Atlantic tropical cyclone (TC) activity under a high-emission scenario is projected using a statistical synthetic storm model coupled with nine phase 6 of the Coupled Model Intercomparison Project (CMIP6) climate models. The ensemble projection shows that the annual frequency of TCs generated in the basin will decrease from 15.91 (1979–2014) to 12.16 (2075–2100), and TC activity will shift poleward and coastward. The mean of lifetime maximum intensity will increase from 66.50 to 75.04 kt (1 kt ≈ 0.51 m s−1). Large discrepancies in TC frequency and intensity projections are found among the nine CMIP6 climate models. The uncertainty in the projection of wind shear is the leading cause of the discrepancies in the TC climatology projection, dominating the uncertainties in the projection of thermodynamic parameters such as potential intensity and saturation deficit. The uncertainty in the projection of wind shear may be related to the different projections of horizontal gradient of vertically integrated temperature in the climate models, which can be induced by different parameterizations of physical processes including surface process, sea ice, and cloud feedback. Informed by the uncertainty analysis, a surrogate model is developed to provide the first-order estimation of TC activity in climate models based on large-scale environmental features.
Measurement error in longitudinal earnings data: evidence from Germany
Authors: Schmillen Achim , Umkehrer Matthias , von Wachter Till 
Published: June 2024

AbstractWe present evidence on the extent of measurement error in German longitudinal earnings data. Qualitatively, we confirm the main result of the international literature: longitudinal earnings data are relatively reliable in a cross section but much less so in first differences. Quantitatively, in the cross section our findings are very similar to those of Bound and Krueger (J Labor Econ 9:1–24, 1991) and Pischke (J Bus Econ Stat 13:305–314, 1995) for the United States while we find even stronger evidence that first-differencing exacerbates measurement error problems. We also show that measurement error in our survey data is not “classical” as it is negatively correlated with administrative earnings and positively autocorrelated over an extended period of time. Additionally, we estimate a model of measurement error stemming from underreporting of transitory earnings shocks in combination with a white-noise component and make a number of methodological contributions. Our results are robust to the use of two different linked survey-administrative data sets and various other sensitivity checks.
ED50 of ciprofol combined with sufentanil for fiberoptic bronchoscopy of different patient populations with pulmonary tuberculosis
Authors: Pan Min , Liu Weidong , Zhang Zhixin , Li Tong , Xie Weibin 
Published: June 2024

AbstractBackgroundCiprofol is a promising sedative. This study aims to explore the median effective dose (ED50) of ciprofol in inhibiting responses to fiberoptic bronchoscopy in patients with pulmonary tuberculosis (PTB) of different genders and ages when combined with 0.15 μg/kg sufentanil, and to evaluate its efficacy and safety, providing a reference for the rational use of ciprofol in clinical practice.MethodsPTB patients who underwent bronchoscopy examination and treatment at The Third People’s Hospital of Changzhou between May 2023 and June 2023 were selected and divided into four groups using a stratified random method. All patients received intravenous injection of 0.15 μg/kg sufentanil followed by injection of the test dose of ciprofol according to Dixon’s up-and-down method. The initial dose of ciprofol in all four groups was 0.4 mg/kg, with an adjacent ratio of 1:1.1. The next patient received a 10% increase in the dose of ciprofol if the previous patient in the same group experienced positive reactions such as choking cough, frowning, and body movements during the endoscopy. Otherwise, it was judged as a negative reaction, and the next patient received a 10% decrease in the dose of ciprofol. The transition from a positive reaction to a negative reaction was defined as a turning point, and the study of the group was terminated when seven turning points occurred. Hemodynamic parameters, oxygen saturation and adverse reactions were recorded at different time points in all groups. The Probit regression analysis method was used to calculate the ED50 of ciprofol in the four groups and compare between the groups.ResultsThe ED50 of ciprofol combined with 0.15 μg/kg sufentanil for bronchoscopy in the four groups were 0.465 mg/kg, 0.433 mg/kg, 0.420 mg/kg and 0.396 mg/kg, respectively.ConclusionThe ED50 of ciprofol used for fiberoptic bronchoscopy varied among PTB patients of different genders and ages.Trial registrationThe Chinese Clinical Trial Registry, ChiCTR2300071508, Registered on 17 May 2023.
Risk for cardiovascular disease development in rheumatoid arthritis
Authors: Bedeković Dražen , Bošnjak Ivica , Bilić-Ćurčić Ines , Kirner Damir , Šarić Sandra , Novak Srđan 
Published: June 2024

Abstract
Background
Patients with rheumatoid arthritis have significant cardiovascular mortality and morbidity.

Objective
To investigate the effects of chronic inflammation in rheumatoid arthritis on cardiovascular morbidity association with cardiovascular risk factors risk factors. Mortality report is secondary just to show trends without sufficient statistical power as it is accidental endpoint.

Methods
A total of 201 individuals without previous cardiovascular disease, 124 with rheumatoid arthritis (investigation group) and 77 with osteoarthritis (control group), were included in the study and followed up for an average of 8 years to assess the development of fatal or non-fatal cardiovascular diseases. The incidence and prevalence of cardiovascular risk factors were also investigated.

Results
The total incidence of one or more fatal or nonfatal cardiovascular events was 43.9% in the investigation group and 37.5% in the control group. Of these patients, 31.7% and 30.9% survived cardiovascular events in the investigation and control groups, respectively. The most common cardiovascular disease among participants who completed the study and those who died during the study was chronic heart failure. The results of the subgroup analysis showed that strict inflammation control plays a central role in lowering cardiovascular risk.

Conclusion
A multidisciplinary approach to these patients is of paramount importance, especially with the cooperation of immunologists and cardiologists for early detection, prevention, and management of cardiovascular risks and diseases.
Methodological identification of anomalies episodes in ECG streams: a systematic mapping study
Authors: Iqbal Uzair , Almakki Riyad , Usman Muhammad , Altameem Abdullah , Albathan Mubarak , Jilani Abdul Khader 
Published: June 2024

AbstractAn electrocardiogram is a medical examination tool for measuring different patterns of heart blood flow circle either in the form of usual or non-invasive patterns. These patterns are useful for the identification of morbidity condition of the heart especially in certain conditions of heart abnormality and arrhythmia. Myocardial infarction (MI) is one of them that happened due to sudden blockage of blood by the cause of malfunction of heart. In electrocardiography (ECG) intensity of MI is highlighted on the basis of unusual patterns of T wave changes. Various studies have contributed for MI through T wave’s classification, but more to the point of T wave has always attracted the ECG researchers. Methodology. This Study is primarily designed for proposing the combination of latest methods that are worked for the solutions of pre-defined research questions. Such solutions are designed in the form of the systematic review process (SLR) by following the Kitchen ham guidance. The literature survey is a two phase’s process, at first phase collect the articles that were published in IEEE Xplore, Scopus, science direct and Springer from 2008 to 2023. It consist of steps; the first level is executed by filtrating the articles on the basis of keyword phase of title and abstract filter. Similarly, at two level the manuscripts are scanned through filter of eligibility criteria of articles selection. The last level belongs to the quality assessment of articles, in such level articles are rectified through evaluation of domain experts. Results. Finally, the selected articles are addressed with research questions and briefly discuss these selected state-of-the-art methods that are worked for the T wave classification. These address units behave as solutions to research problems that are highlighted in the form of research questions. Conclusion and future directions. During the survey process for these solutions, we got some critical observations in the form of gaps that reflected the other directions for researchers. In which feature engineering, different dependencies of ECG features and dimensional reduction of ECG for the better ECG analysis are reflection of future directions.
Astragaloside IV inhibits cell viability and glycolysis of hepatocellular carcinoma by regulating KAT2A-mediated succinylation of PGAM1
Authors: Zhu Yuanzhang , Lu Fei 
Published: June 2024

Abstract
Background
Astragaloside IV (AS-IV) is one of the basic components of Astragali radix, that has been shown to have preventive effects against various diseases, including cancers. This study aimed to explore the role of AS-IV in hepatocellular carcinoma (HCC) and its underlying mechanism.

Methods
The cell viability, glucose consumption, lactate production, and extracellular acidification rate (ECAR) in SNU-182 and Huh7 cell lines were detected by specific commercial kits. Western blot was performed to analyze the succinylation level in SNU-182 and Huh7 cell lines. The interaction between lysine acetyltransferase (KAT) 2 A and phosphoglycerate mutase 1 (PGAM1) was evaluated by co-immunoprecipitation and immunofluorescence assays. The role of KAT2A in vivo was explored using a xenografted tumor model.

Results
The results indicated that AS-IV treatment downregulated the protein levels of succinylation and KAT2A in SNU-182 and Huh7 cell lines. The cell viability, glucose consumption, lactate production, ECAR, and succinylation levels were decreased in AS-IV-treated SNU-182 and Huh7 cell lines, and the results were reversed after KAT2A overexpression. KAT2A interacted with PGAM1 to promote the succinylation of PGAM1 at K161 site. KAT2A overexpression promoted the viability and glycolysis of SNU-182 and Huh7 cell lines, which were partly blocked following PGAM1 inhibition. In tumor-bearing mice, AS-IV suppressed tumor growth though inhibiting KAT2A-mediated succinylation of PGAM1.

Conclusion
AS-IV inhibited cell viability and glycolysis in HCC by regulating KAT2A-mediated succinylation of PGAM1, suggesting that AS-IV might be a potential and suitable therapeutic agent for treating HCC.
Loneliness shapes disparities in healthy life expectancy: a multi-state analysis from China
Authors: Yu Qi , Ren Yiting , Wu Jilei 
Published: June 2024

Abstract
Objectives
To assess the influence of loneliness on the healthy life expectancy of older adults in China and its gender disparities across different health indicators, in order to provide insights for enhancing the health status and subjective well-being of the older population.

Method
We conducted a cohort analysis using four waves of weighted samples (2008, 2011, 2014, and 2018) from the Chinese Longitudinal Healthy Longevity Survey, encompassing 15,507 respondents aged 65–99. Physical and subjective health were assessed through activity of daily living (ADL) and self-rated health (SRH), respectively. Utilizing loneliness status as a time-variant variable, we employed the multi-state interpolated Markov Chain to explore the associations between loneliness and age-specific life expectancy (LE), healthy life expectancy (HLE), and the proportion of healthy life expectancy in life expectancy (HLE/LE).

Results
Compared to the non-lonely population, both LE and HLE were lower among lonely individuals. Regarding gender differences, the HLE/LE for females in the lonely population was consistently lower than that for males. The impact of loneliness on the health of older adults varied by measurement indicators and gender. Specifically, based on ADL results, the decline in HLE/LE was greater for females, with a decline of 53.6% for lonely females compared to 51.7% for non-lonely females between the ages of 65 and 99. For males, the decline was 51.4% for lonely males and 51.5% for non-lonely males. According to SRH, the gender difference in the decline of HLE/LE due to loneliness was less apparent. For males, the change in HLE/LE for non-lonely individuals was 3.4%, compared to 4.2% for lonely individuals, whereas for females, the change was 3.7% for non-lonely individuals and 4.4% for lonely individuals.

Conclusion
Loneliness exerts varied effects on health across different measurement indicators and gender demographics. Targeted health promotion interventions are imperative to mitigate these negative impacts, particularly emphasizing the enhancement of subjective well-being and physical functioning, especially among older adult females.
Trends of fear and anger on YouTube during the initial stage of the COVID-19 outbreak in South Korea
Authors: Lee Jae-Joon , Kim Jongwoo , Lee Soo-Kyoung 
Published: June 2024

Abstract
Background
The COVID-19 pandemic has been the most widespread and threatening health crisis experienced by the Korean society. Faced with an unprecedented threat to survival, society has been gripped by social fear and anger, questioning the culpability of this pandemic. This study explored the correlation between social cognitions and negative emotions and their changes in response to the severe events stemming from the COVID-19 pandemic in South Korea.

Methods
The analysis was based on a cognitive-emotional model that links fear and anger to the social causes that trigger them and used discursive content from comments posted on YouTube’s COVID-19-related videos. A total of 182,915 comments from 1,200 videos were collected between January and December 2020. We performed data analyses and visualizations using R, Netminer 4.0, and Gephi software and calculated Pearson’s correlation coefficients between emotions.

Results
YouTube videos were analyzed for keywords indicating cognitive assessments of major events related to COVID-19 and keywords indicating negative emotions. Eight topics were identified through topic modeling: causes and risks, perceptions of China, media and information, infection prevention rules, economic activity, school and infection, political leaders, and religion, politics, and infection. The correlation coefficient between fear and anger was 0.462 (p < .001), indicating a moderate linear relationship between the two emotions. Fear was the highest from January to March in the first year of the COVID-19 outbreak, while anger occurred before and after the outbreak, with fluctuations in both emotions during this period.

Conclusions
This study confirmed that social cognitions and negative emotions are intertwined in response to major events related to the COVID-19 pandemic, with each emotion varying individually rather than being ambiguously mixed. These findings could aid in developing social cognition-emotion-based public health strategies through education and communication during future pandemic outbreaks.