bluuebunny/crossref_metadata_2025_split huggingface dataset:
A study on appropriate use and stewardship of proton pump inhibitors
Authors: Mondal Naresh , Maity Shilpi , Phawa Alamki , Roy Bireswar , Satheesh Kumar E. , Narayana Swamy V.B  
Published: May 2024

Objective: To analyze the prescribing pattern of use of PPI with respect to “FDA-Approved Indications and Doses for PPI Therapy.” Materials and Methods: After obtaining approval from the Institutional Ethics Committee, a cross-sectional study was carried out among 400 inpatients in a tertiary care hospital in Bangalore. The data were collected from the patient case profile and prescriptions and noted in a self-designed data collection form. The statistical analysis of the collected data was performed using SPSS software and Excel. Results: The study, conducted on 400 patients, revealed a male majority (60%) and a female representation of 40%. Proton Pump Inhibitors (PPIs), mainly Pantoprazole (74.70%), were frequently prescribed, notably in General Medicine (220 patients). PPI use was generally appropriate: indication (99%), dose (97%), frequency (92.8%), and duration (91.8%). However, irrational prescriptions were noted: indication (1%), dose (3%), frequency (7.3%), and duration (8.3%). 139 drug interactions were identified, categorized into Major (39.6%), Moderate (46%), and Minor (14.4%). For example, Ondansetron and tramadol exhibited a major interaction. Among PPI combinations, 93.75% could affect CYP2C19 metabolism, and 6.3% had additive/synergistic toxicity potential.
Crisis del 2008 y su incidencia en la salud. Un análisis de lo que sucedió en la provincia de Cádiz
Authors: Oñate-Tenorio Antonio , Muñoz-Sánchez Práxedes , Oñate Tenorio María de los Santos 
Published: May 2024

Las crisis económicas provocan una serie de problemas relacionados con la salud, como la disminución de los recursos sanitarios públicos, la pérdida de relaciones sociales e incluso la pérdida intencionada de la vida por suicidio. Este artículo presenta una investigación que analiza la relación entre salud y crisis económicas. Su objetivo es revelar no solo los efectos de las recesiones económicas en los estados de salud individuales, sino también las repercusiones más amplias en la salud pública. La exploración se lleva a cabo mediante una metodología cualitativa híbrida basada en 21 entrevistas en profundidad y sesiones realizadas con dos grupos focales. Estos debates ponen de relieve los problemas relacionados con la salud de las personas durante las crisis económicas, incluida la mala alimentación y las repercusiones en la vida familiar. En particular, el estudio también aborda cuestiones como las dificultades para adquirir medicamentos durante las recesiones económicas y la desatención de las patologías no relacionadas con la COVID-19 durante la reciente pandemia de COVID-19. La investigación concluye que las crisis influyen negativamente en dos ámbitos principales: la reducción de los servicios sanitarios básicos y el deterioro de la salud de las personas, lo que conlleva posteriormente una disminución de su bienestar social general.
Los desechos del canon
Authors: Fernandez Juan Manuel 
Published: May 2024

En los ensayos de Paul Groussac publicados en La Biblioteca, sobre todo en “La educación por el folletín” (1897), se hace manifiesta una inquietud del canon crítico argentino frente a una producción literaria a la que se concibe como basura, en plena proliferación y dirigida a una población a la que se piensa también como un desecho social. En un abordaje de la recepción contemporánea de Zola por parte de jóvenes escritores profesionales, Groussac impugna, primeramente, una literatura del escritor militante, dirigida al gran público, en la que resuena el conflicto social que involucra a los obreros y al lumpen. La crítica al folletín supone también una respuesta conservadora frente a tendencias políticas y estéticas modernas que considera disolventes, en defensa de un concepto de sociedad apolíneo, centrado en la familia, coherente con los principios civilizatorios, científico-sociales y morales, de la latinidad y la cristiandad. Sus producciones críticas y literarias dialogan también con los discursos gubernamentales y con las tesis crepusculares de la psiquiatría contemporánea. En ellas puede hallarse una oscilación entre un rol higienista, que distingue lo saludable de lo patológico en las artes y las ciencias, y una experimentación o asimilación de esta producción literaria destinada al excedente social, que lo posiciona, inesperadamente, como escritor de literatura folletinesca.
Groussac publicados en La biblioteca, sobre todo en “La educación por el folletín” (1897), se hace manifiesta una inquietud del canon crítico argentino frente a una producción literaria a la que se concibe como basura, en plena proliferación y dirigida a una población a la que se piensa también como un desecho social. En un abordaje de la recepción contemporánea de Zola por parte de jóvenes escritores profesionales, Groussac impugna, primeramente, una literatura del escritor militante, dirigida al gran público, en la que resuena el conflicto social que involucra a los obreros y al lumpen. La crítica al folletín supone también una respuesta conservadora frente a tendencias políticas y estéticas modernas que considera disolventes, en defensa de un concepto de sociedad apolíneo, centrado en la familia, coherente con los principios civilizatorios, científico-sociales y morales, de la latinidad y la cristiandad. Sus producciones críticas y literarias dialogan también con los discursos gubernamentales y con las tesis crepusculares de la psiquiatría contemporánea. En ellas puede hallarse una oscilación entre un rol higienista, que distingue lo saludable de lo patológico en las artes y las ciencias, y una experimentación o asimilación de esta producción literaria destinada al excedente social, que lo posiciona, inesperadamente, como escritor de literatura folletinesca.
Late Bone Marrow Mononuclear Cell Transplantation in Rats with Sciatic Nerve Crush. Analysis of a Potential Therapeutic Time Window.
Authors: Usach Vanina , Casadei Mailin , Piñero Gonzalo , Vence Marianela , Soto Paula , Cueto Alicia , Brumovsky Pablo , Setton-Avruj Clara Patricia 
Published: May 2024

After peripheral nerve injury, axon and myelin regeneration are key events for optimal clinical improvements. We have previously shown that early bone marrow mononuclear cell (BMMC) transplantation exerts beneficial effects on myelin regeneration. In the present study we analyze whether there is a temporal window in which BMMC migrate more efficiently to damaged nerves while still retaining their positive effects. Adult Wistar rats of both sexes, with sciatic nerve crush were systemically transplanted with BMMC at different days post injury. Vehicle-treated, naïve, and sham rats were also included. Morphological, functional, and behavioral analyses were performed in nerves from each experimental group at different survival times. BMMC transplantation between 0 and 7 days after injury resulted in the largest number of nested cells within the injured sciatic nerve, which supports the therapeutic value of BMMC administration within the first week after injury. Most importantly, later BMMC administration 7 days after sciatic nerve crush was associated with neuropathic pain reversion, improved morphological appearance of the damaged nerves, and a tendency toward faster recovery in the sciatic functional index and electrophysiological parameters. Our results thus support the notion that even delayed BMMC treatment may represent a promising therapeutic strategy for peripheral nerve injuries.
Analysis of Three Methods to Reduce Bottom Hole Temperature While Drilling in Deep Shale Gas Well: Circulation, Ground Cooling, and Mud Density Reduction
Authors: Zhang G. , Tang M. , Lei H. , He S. , Kong L. , Wang S. 
Published: May 2024

Abstract
During deep shale gas well drilling process, high bottom hole temperature (≥150°C) often causes the conventional rotary steerable tool and logging while drilling (LWD) to malfunction. Therefore, it is essential to reduce the bottom hole temperature for safe and efficient drilling. In this paper, a simplified wellbore temperature model for deep shale gas horizontal well was established based on thermodynamic theory, comprehensively accounting for both mechanical and hydraulic heat source. According to the temperature model, a comparative and analytical investigation is conducted on the applicability range of three cooling methods: circulation, ground cooling, and density reduction. Building upon these research findings, a density reduction scheme is proposed and subsequently implemented on the H29 platform in Luzhou block for field application and cooling effect evaluation. The results indicated that the temperature model is in good agreement with real-time temperature data with an error less than ± 5 %. Variations in mud density also lead to changes in rheological parameters, consequently impacting bottom hole temperature. If the horizontal section is shorter than 1000 m, reducing the inlet temperature can effectively reduce the bottom hole temperature. But once the horizontal section exceeds 1500 m, reducing mud density is much more effective. With field application on H-29-1 and H-29-6, mud density was reduced from 2.25 g/cm3 to 1.80 g/cm3, resulting in a maximum bottom hole temperature of 143°C in the horizontal section, and rotary steerable tools and screw worked stably in downhole. Compared to the other wells that bottom hole temperatures are all above 152 °C (up to 155.7 °C), the maximum bottom hole temperature decreased by 9-14°C. Furthermore, in the horizontal section, the pure drilling time is significantly reduced, no overflow, sticking and other accidents occur, and the Rate of Penetration (ROP) is increased by more than 45 %, the pump pressure is reduced by 2-5MPa. All phenomena show that lower mud density can not only effectively reduce the bottom hole temperature, but also improve the drilling efficiency, which has positive significance for the development of deep shale gas.
GRE Lined Carbon Steel Tubing Performance in Sweet Corrosion Environments for Wells Equipped with Electrical Submersible Pumps
Authors: Al-Majdli A. F. , Al-Methen B. , Al-Hasash B. W. , Al-Mutairi M. , Rajagopalan V. , Suryadi R. , Al-Ajeel H. , Al-Harbi N. 
Published: May 2024

Abstract
The majority of oil production at the Kuwait Oil Company (KOC) rely on Electrical Submersible Pumping (ESP) systems. One such reservoir in Kuwait with over than 120 producing well equipped with electrical submersible Pumps are exposed to a harsh production environments including corrosive fluids (sweet corrosion due to presence of Co2). Historical data shows that over 40% of all pulled Electrical Submersible Pumps where dismantle inspection and failure analysis (DIFA) were performed in the past 4 to 5 years within the field have failed due to corrosion within the well completion (mainly corrosion in the tubing) or in Electrical Submersible Pump components. When analyzing existing data (reservoir, design, equipment specifications, operation and DIFA) the majority of failed wells equipped with Electrical Submersible Pump show signs of corrosion in the tubing although they rarely appear on the ESP components. Further analysis shows that 80% of these completion (mainly tubing) failures occur between 4 to 18 months where the tubing used in these cases are all found to be of carbon steel metallurgy.
Sweet corrosion is one of the major issues for wells equipped with electrical submersible Pump in one of reservoir located in Kuwait. An increase in water cut percentages in the reservoir has led to increased CO2 corrosion rate in the saline formation water (high chloride level). The collected data shows that more than 40% of all pulled electrical submersible Pumps where DIFA have been performed were due to corrosion in the completion components (mainly corrosion hole in the tubing).
As a proactive measure, KOC have been installing Internally Glass Reinforced Epoxy (GRE) lined carbon steel tubing for wells that have corrosion related tubing failures. In additional, KOC decided to enhance the Electrical Submersible Pump components specifications to mitigate the risk related to sweet corrosion.
This paper shows a field study for 36 cases where Internally Glass Reinforced Epoxy lined carbon steel tubing were used on existing failed wells due to corrosion to evaluate the effectiveness of using GRE lined tubing when exposed to the same harsh environments (sweet corrosion) and the resulting equipment run life. When compared with conventional carbon steel tubing, a significant increase in run life and reduction of numbers of completion failures are recorded. Over all, the average run life for all cases has improved by over 422 days.
This study will help ESP operators facing similar challenges to understand the effectiveness of using Internally Glass Reinforced Epoxy lined carbon steel tubing as a replacement for conventional carbon steel tubing towards mitigating sweet corrosion environments.
Mechanism and Pressure Behavior of Fracturing Flooding Wells in Tight Reservoir
Authors: Wang Yang , Weng Zhoutian , Kadet Valery V. , Feng Naichao 
Published: May 2024

Abstract
Fracturing flooding is a new energy-supplement technique emerging in recent years, which requires delivering high-efficiency oil agents to the sites with enriched remaining oil through fracturing. In this paper, we introduce the main characteristics of fracturing flooding technique. The pressure responses of induced horizontal fracture of injection well is obtained by modelling the fluid flow in the fractures with variable-mass-radial flow by point source method. The fracture-closure induced flow-rate change is considered by Duhamel’s principle. Compared with conventional fractured well, the fracture properties in fracturing flooding wells vary with time during the shut-in testing period since they are not strengthened by proppants. Linear-flow analysis, fracture-storage coefficient analysis, and fracturing flooding interference analysis methods are comprehensively discussed and compared to estimate the fracture parameters based on the measured bottom-hole pressure data.
Mitigating Well Integrity Challenges of Vintage Wells: A Case Study from Mumbai Offshore Field
Authors: Jose Justin , Yahiya Nazarul , Chowdhury Biswajit , Bhatnagar Ajay , Garg BP 
Published: May 2024

Abstract
Vintage wells, characterized by their age, often present structural integrity challenges, necessitating specialized approaches to ensure their safety and longevity. In Mumbai’s offshore region, the operator oversees over 250 wellhead platforms, the majority of which are more than 25 years old. Given the high demand for increased recovery factors and production rates, a comprehensive well rehabilitation strategy was imperative.
Prior to the rig deployment, based on various comprehensive assessments, found that surface casing parted below the wellhead in five specific wells due to severe corrosion. In light of the findings, all wellheads, 30" conductor casings, 20" surface casings, and in a few cases, the 13 3/8" intermediate casings were replaced, specifically from the boat landing deck. The onset of the monsoon season was an additional challenge faced by this project. With the help of pre job analysis, planning and the on-site execution, the integrity of the five wells has been reinstated. It helped in avoiding the abandonment of existing wells, slot recovery activities like changing the entire conductor and surface casings and further drilling of new wells with different directional trajectories. The uncertainties faced are controlling gas bubbling from the annulus of 9 5/8" (production casing) - 13 3/8" (intermediate casing) in one of the wells and requirement of changing intermediate casing (13 3/8") in another well. The method of carrying out the casing replacement activity from the boat landing deck was implemented in consideration with prevailing oil and gas standards and procedures. Thereby, the three water injector wells are serving their intended purpose by contributing to the improvement of reservoir pressure, while the two oil producer wells are enhancing oil exploitation from the carbonate reservoir.
The implementation of innovative methods, comprehensive risk analyses, and stringent safety precautions contributed to the timely and efficient completion of the project, ultimately enhancing reservoir pressure and augmenting oil production from the carbonated reservoir. This paper provides a detailed account of the methodology, pre-job planning for casing repair and wellhead replacement, on-site execution, successful completion of the well restoration process, and the precautionary initiatives to address possible casing integrity issues in the future.
Advanced Produced Water Management in the Oil and Gas Industry: A Comprehensive Examination of Cutting-Edge Treatment Technologies
Authors: Khammo M. , Obedkov A. , Aljarwan R. , Alhebshi M. , Alnuaimi H. , Almri M. , Hassan A. 
Published: May 2024

Abstract
The examination of advanced produced water treatment technologies reveals their remarkable effectiveness in reducing total suspended solids (TSS), oil-in-water content, and improving water quality. Various case studies confirm significant reductions in TSS levels and a substantial decrease in oil-in-water content, demonstrating the efficiency of advanced membrane filtration, electrocoagulation, and biological treatment systems.
Moreover, these advanced technologies offer enhanced operational flexibility, enabling oil and gas operators to adapt their treatment processes to varying water compositions and flow rates. This adaptability is particularly crucial in regions with stringent environmental regulations, where maintaining compliance is paramount.
Furthermore, the technical case study provides comprehensive data-driven insights. It underscores that the integrated treatment system not only met but exceeded expectations. Rigorous analytical assessments validate the attainment of stringent compliance with regional environmental statutes and permit requirements. Notably, a substantial reduction in off-site produced water disposal volume was achieved, supported by meticulous data analysis, reflecting significant cost savings and a reduced environmental footprint.
The implementation of advanced monitoring and control systems represents a significant advancement in the optimization of produced water treatment processes. These systems leverage real-time data monitoring, enabling operators to continuously track key treatment parameters such as flow rates, pressure, temperature, and water quality indicators.
Furthermore, real-time data monitoring allows operators to identify potential issues or inefficiencies in the treatment process early on. By addressing these issues promptly, operators can prevent costly downtime and production losses. Additionally, these systems can generate detailed performance reports and analytics, providing operators with valuable insights into the overall efficiency and effectiveness of their treatment processes.
Overall, the implementation of advanced monitoring and control systems has revolutionized produced water treatment operations by enhancing efficiency, reducing operational costs, and improving overall process reliability
In conclusion, this research underscores the tangible accomplishments of advanced produced water treatment technologies in practical applications. These technologies, validated by comprehensive data analysis, offer economic, environmental, and operational advantages, making them a valuable addition to the oil & gas industry’s best practices. Advanced treatment technologies not only enhance environmental stewardship but also drive operational efficiencies and cost-effectiveness, positioning them as integral components of sustainable water management strategies in the oil & gas sector.
Low Salinity Water and Foam Flooding in Sandstone Reservoirs Bearing Heavy Oil
Authors: Al-Saedi Hasan N. , Al-Rubaye Wisam I. , Kassim Ali , Fakhir Rahman , Al-Bazzaz Waleed , Al-Sayegh Salih , E. Flori Ralph 
Published: May 2024

Abstract
This study investigates foam and water flooding (especially low salinity (LS) water flooding). Generally, injecting LS water alters sandstone wettability towards being more water-wet, is an effective EOR technique that improves oil recovery. Foams were also employed to enhance oil recovery due to its ability to increase residual oil mobility and sweep efficiency. Combining both LS water and foam into a novel attempt that takes advantage of the relative strengths of both EOR methods. This EOR combination was tested on Berea sandstone cores saturated with heavy oil. The ultimate outcome from this work is a "recipe" of EOR methods in combination, which utilizes LS water and foam to achieve recovery of over 72.65 percent of OOIP in core flooding tests. The core-flooding results showed that an increased heavy oil recovery was obtained by injecting foam and lowering water salinity. The contact angle and interfacial tension (IFT) measurements agreed with the core-flooding results.