bluuebunny/crossref_metadata_2025_split huggingface dataset:
Posttreatment prognosis of patients with esthesioneuroblastoma
Authors: Kane Ari J. , Sughrue Michael E. , Rutkowski Martin J. , Aranda Derick , Mills Steve A. , Buencamino Raphael , Fang Shanna , Barani Igor J. , Parsa Andrew T. 
Published: March 2010

Object
There is no Class I evidence to guide the appropriate management of esthesioneuroblastoma (EN). Most data currently guiding treatment come from small- or modest-sized series gathered at individual centers that have concluded that surgery with radiotherapy is the preferred treatment. In this study, the authors summarize the published literature on treatment outcomes in patients with EN. The objective was to ascertain what variables predict prognosis in these patients and to determine the relative effect of different therapies.

Methods
The authors identified 205 published studies containing treatment outcomes for surgery, radiotherapy, chemotherapy, or multimodal treatment. Using Kaplan-Meier analysis, the survival of patients who received surgery was compared with that in those who received surgery and radiotherapy. Additionally, Kadish staging was compared with low- and high-grade Hyams criteria to assess for subgroup prognostic significance in survival differences.

Results
Nine hundred fifty-six patients met the inclusion criteria, with a median follow-up time of 3 years. Kaplan-Meier analysis demonstrated no difference in survival between patients who underwent surgery alone and those who underwent surgery plus radiotherapy at 5 years (78 vs 75%) or 10 years (67 vs 61%, respectively) (p = 0.3). Univariate analysis demonstrated worse survival in cases involving Kadish Grade C tumors, Hyams Grade 3 and 4 tumors, and in patients older than 65 years of age. Multivariate analysis demonstrated that Hyams Grade 3 and 4 lesions carried significant risk (proportional hazard = 4.83, p < 0.001) with 5- and 10-year survival of 47 and 31%.

Conclusions
A biopsy should always be obtained in cases suspected of EN because histology is a strong prognostic indicator and will help guide appropriate treatment. Unimodal surgery and combined surgery/radiotherapy appear to be of equivalent efficacy with respect to survival in patients with EN. Chemotherapy should be considered in high-grade EN.
The Role of Peritoneal Lavage and the Prognostic Significance of Mesothelial Cell Area in Preventing Encapsulating Peritoneal Sclerosis
Authors: Yamamoto Tadashi , Nagasue Kyoko , Okuno Senji , Yamakawa Tomoyuki 
Published: March 2010

♦ Background Severe peritoneal injury and encapsulating peritoneal sclerosis (EPS) as complications of long-term peritoneal dialysis (PD) are issues of concern. The usefulness of peritoneal lavage after withdrawal of PD and the risk factors for EPS have not been addressed until now. Little is known about mesothelial cell area (MCA) in the effluent as a marker of peritoneal injury. In the present study, we investigated the clinical significance of peritoneal lavage after PD withdrawal and tried to clarify the risk factors related to MCA, with the aim of preventing EPS. We also developed an algorithm for the clinical management of long-term PD patients. ♦ Methods We assigned 247 PD patients to one of two cohorts after PD withdrawal: a non-lavage group (73 patients) and a lavage group (174 patients). To clarify the risk factors, we studied these potential predictors: PD duration, dialysate-to-plasma ratio of creatinine (D/P Cr) at the time of PD withdrawal, frequency of peritoneal lavage, type of PD or lavage solution, MCA at the time of PD withdrawal (“PD area”), and MCA at the time of peritoneal lavage withdrawal or censoring (“LA area”). Recurrent intestinal obstruction was defined as the main manifestation of EPS. Diagnostic performance and cut-off values were then calculated for the selected risk factors. ♦ Results The overall incidence of EPS was significantly lower in the lavage group, at 6.9% (5.2% during lavage and 2.5% after lavage), than in the non-lavage group, at 15.1%. The risk factors and cut-off values were PD area (350 μm2) and PD duration (78 months) for the non-lavage group; and PD area (350 μm2) and LA area (320 μm2) for the lavage group. Patients with a PD duration of 78 months or more and a PD area of 350 μm2 or more were defined as high-risk patients in the non-lavage group (risk ratio: 11.14), and patients with a PD area of 350 μm2 or more and an LA area of 320 μm2 or more were defined as high-risk patients in the lavage group (risk ratio: 10.43). ♦ Conclusions Peritoneal lavage is effective in reducing the incidence of EPS after PD withdrawal. The PD duration and MCA are significant risk factors, and these markers are useful for classifying patients into low- and high-risk groups for the development of EPS.
Factors Associated with Blood Concentrations of Indoxyl Sulfate and p-Cresol in Patients Undergoing Peritoneal Dialysis
Authors: Lee Chien-Te , Kuo Chien-Chun , Chen Yu-Ming , Hsu Chung-Yao , Lee Wen-Chin , Tsai Yu-Che , Ng Hwee-Yeong , Kuo Li-Chueh , Chiou Terry Ting-Yu , Yang Yu-Kun , Cheng Ben-Chung , Chen Jin-Bor 
Published: March 2010

Background Accumulating evidence supports the important role of protein-bound uremic toxins such as indoxyl sulfate and p-cresol in uremic syndrome. They exert direct deleterious effects on a variety of cells and could link to clinical outcome. Factors relevant to indoxyl sulfate and p-cresol levels in peritoneal dialysis (PD) patients have rarely been investigated. We conducted a cross-sectional study to analyze the factors that correlate with both total and free indoxyl sulfate and p-cresol. Methods 182 stable PD patients with mean PD therapy duration 38.5 ± 33.3 months were enrolled. Their mean age was 48.9 ± 13.5 years; 62.6% (114/182) were female patients. Demographic data, including age, gender, and PD therapy duration, were reviewed and recorded. PD-associated features such as residual kidney function (RKF), peritoneal transport property, and dialysis modality were also recorded. Hemoglobin, blood urea nitrogen (BUN), serum creatinine, C-reactive protein, interleukin (IL)-6, and IL-10 were measured. Levels of total and free indoxyl sulfate and p-cresol were determined. Results Patients without RKF had lower Kt/V and weekly creatinine clearance and higher serum creatinine and IL-6 levels. These patients also had higher total and free indoxyl sulfate levels. There was no difference in indoxyl sulfate or p-cresol levels compared to patients with different peritoneal transport properties or with different treatment modalities. Multivariate regression analysis revealed that weekly creatinine clearance and serum creatinine were independent associates of total indoxyl sulfate level; IL-6, total indoxyl sulfate, and free p-cresol were associated with free indoxyl sulfate level. Weekly creatinine clearance and free p-cresol level independently correlated with total p-cresol; while gender, total p-cresol, and free indoxyl sulfate were associated with free p-cresol level. Conclusion The free forms of indoxyl sulfate and p-cresol constituted a small portion of their total forms. The presence of RKF affected levels of free and total indoxyl sulfate. IL-6 level was significantly associated with free indoxyl sulfate level. There was a close relationship between indoxyl sulfate and p-cresol levels in their free forms in PD patients.
Comparison of Sales From Vending Machines With 4 Different Food and Beverage Messages
Authors: Gibson Laura A. , Stephens-Shields Alisa J. , Hua Sophia V. , Orr Jennifer A. , Lawman Hannah G. , Bleich Sara N. , Volpp Kevin G. , Bleakley Amy , Thorndike Anne N. , Roberto Christina A. 
Published: May 2024

ImportancePoint-of-sale food messaging can encourage healthier purchases, but no studies have directly compared multiple interventions in the field.ObjectiveTo examine which of 4 food and beverage messages would increase healthier vending machine purchases.Design, Setting, and ParticipantsThis randomized trial assessed 13 months (February 1, 2019, to February 29, 2020) of vending sales data from 267 machines and 1065 customer purchase assessments from vending machines on government property in Philadelphia, Pennsylvania. Data analysis was performed from March 5, 2020, to November 8, 2022.InterventionsStudy interventions were 4 food and beverage messaging systems: (1) beverage tax posters encouraging healthy choices because of the Philadelphia tax on sweetened drinks; (2) green labels for healthy products; (3) traffic light labels: green (healthy), yellow (moderately healthy), or red (unhealthy); or (4) physical activity equivalent labels (minutes of activity to metabolize product calories).Main Outcomes and MeasuresSales data were analyzed separately for beverages and snacks. The main outcomes analyzed at the transaction level were calories sold and the health status (using traffic light criteria) of each item sold. Additional outcomes were analyzed at the monthly machine level: total units sold, calories sold, and units of each health status sold. The customer purchase assessment outcome was calories purchased per vending trip.ResultsMonthly sales data came from 150 beverage and 117 snack vending machines, whereas 1065 customers (558 [52%] male) contributed purchase assessment data. Traffic light labels led to a 30% decrease in the mean monthly number of unhealthy beverages sold (mean ratio [MR], 0.70; 95% CI, 0.55-0.88) compared with beverage tax posters. Physical activity labels led to a 34% (MR, 0.66; 95% CI, 0.51-0.87) reduction in the number of unhealthy beverages sold at the machine level and 35% (MR, 0.65; 95% CI, 0.50-0.86) reduction in mean calories sold. Traffic light labels also led to a 30-calorie reduction (b = −30.46; 95% CI, −49.36 to −11.56) per customer trip in the customer purchase analyses compared to physical activity labels. There were very few significant differences for snack machines.Conclusions and RelevanceIn this 13-month randomized trial of 267 vending machines, the traffic light and physical activity labels encouraged healthier beverage purchases, but no change in snack sales, compared with a beverage tax poster. Corporations and governments should consider such labeling approaches to promote healthier beverage choices.Trial RegistrationClinicalTrials.gov Identifier: NCT06260176
Burden of Mental Disorders and Suicide Attributable to Childhood Maltreatment
Authors: Grummitt Lucinda , Baldwin Jessie R. , Lafoa’i Johanna , Keyes Katherine M. , Barrett Emma L. 
Published: May 2024

ImportanceThe proportion of mental disorders and burden causally attributable to childhood maltreatment is unknown.ObjectiveTo determine the contribution of child maltreatment to mental health conditions in Australia, accounting for genetic and environmental confounding.Design, Setting, and ParticipantsThis meta-analysis involved an epidemiological assessment accounting for genetic and environmental confounding between maltreatment and mental health and 3 cross-sectional national surveys: the Australian Child Maltreatment Study (ACMS) 2023, National Study of Mental Health and Well-being 2020-2022, and Australian Burden of Disease Study 2023. Causal estimates were derived on the association between childhood maltreatment and mental health conditions from a meta-analysis of quasi-experimental studies. This was combined with the prevalence of maltreatment from the ACMS to calculate the population attributable fraction (PAF). The PAF was applied to the number and burden of mental health conditions in Australia, sourced from 2 population-based, nationally representative surveys of Australians aged 16 to 85 years, to generate the number and associated burden of mental disorders attributable to child maltreatment.ExposurePhysical abuse, sexual abuse, emotional abuse, or neglect prior to age 18 years.Main Outcomes and MeasuresProportion and number of cases, years of life lost, years lived with disability, and disability-adjusted life-years of mental health conditions (anxiety, depression, harmful alcohol and drug use, self-harm, and suicide attempt) attributable to childhood maltreatment.ResultsMeta-analytic estimates were generated from 34 studies and 54 646 participants and applied to prevalence estimates of childhood maltreatment generated from 8503 Australians. Childhood maltreatment accounted for a substantial proportion of mental health conditions, ranging from 21% (95% CI, 13%-28%) for depression to 41% (95% CI, 27%-54%) of suicide attempts. More than 1.8 million cases of depressive, anxiety, and substance use disorders could be prevented if childhood maltreatment was eradicated. Maltreatment accounted for 66 143 years of life lost (95% CI, 43 313-87 314), primarily through suicide, and 184 636 disability-adjusted life-years (95% CI, 109 321-252 887).Conclusions and RelevanceThis study provides the first estimates of the causal contribution of child maltreatment to mental health in Australia. Results highlight the urgency of preventing child maltreatment to reduce the population prevalence and burden of mental disorders.
Polygenic liability for anxiety in association with comorbid anxiety in multiple sclerosis
Authors: Kowalec Kaarina , Harder Arvid , Dolovich Casandra , Fitzgerald Kathryn C. , Salter Amber , Lu Yi , Bernstein Charles N. , Bolton James M. , Cutter Gary , Fisk John D. , Gelernter Joel , Graff Lesley A. , Hägg Sara , Hitchon Carol A. , Levey Daniel F. , Lublin Fred D. , McKay Kyla A. , Patten Scott , Patki Amit , Stein Murray B. , Tiwari Hemant K. , Wolinsky Jerry S. , Marrie Ruth A. 
Published: May 2024

AbstractObjectiveComorbid anxiety occurs often in MS and is associated with disability progression. Polygenic scores offer a possible means of anxiety risk prediction but often have not been validated outside the original discovery population. We aimed to investigate the association between the Generalized Anxiety Disorder 2‐item scale polygenic score with anxiety in MS.MethodsUsing a case–control design, participants from Canadian, UK Biobank, and United States cohorts were grouped into cases (MS/comorbid anxiety) or controls (MS/no anxiety, anxiety/no immune disease or healthy). We used multiple anxiety measures: current symptoms, lifetime interview‐diagnosed, and lifetime self‐report physician‐diagnosed. The polygenic score was computed for current anxiety symptoms using summary statistics from a previous genome‐wide association study and was tested using regression.ResultsA total of 71,343 individuals of European genetic ancestry were used: Canada (n = 334; 212 MS), UK Biobank (n = 70,431; 1,390 MS), and the USA (n = 578 MS). Meta‐analyses identified that in MS, each 1‐SD increase in the polygenic score was associated with ~50% increased odds of comorbid moderate anxious symptoms compared to those with less than moderate anxious symptoms (OR: 1.47, 95% CI: 1.09–1.99). We found a similar direction of effects in the other measures. MS had a similar anxiety genetic burden compared to people with anxiety as the index disease.InterpretationHigher genetic burden for anxiety was associated with significantly increased odds of moderate anxious symptoms in MS of European genetic ancestry which did not differ from those with anxiety and no comorbid immune disease. This study suggests a genetic basis for anxiety in MS.
Mitochondrial dysfunction in brain tissues and Extracellular Vesicles Fragile X‐associated tremor/ataxia syndrome
Authors: Yao Pamela J. , Manolopoulos Apostolos , Eren Erden , Rivera Susan Michelle , Hessl David R. , Hagerman Randi , Martinez‐Cerdeno Veronica , Tassone Flora , Kapogiannis Dimitrios 
Published: May 2024

AbstractObjectiveMitochondrial impairments have been implicated in the pathogenesis of Fragile X‐associated tremor/ataxia syndrome (FXTAS) based on analysis of mitochondria in peripheral tissues and cultured cells. We sought to assess whether mitochondrial abnormalities present in postmortem brain tissues of patients with FXTAS are also present in plasma neuron‐derived extracellular vesicles (NDEVs) from living carriers of fragile X messenger ribonucleoprotein1 (FMR1) gene premutations at an early asymptomatic stage of the disease continuum.MethodsWe utilized postmortem frozen cerebellar and frontal cortex samples from a cohort of eight patients with FXTAS and nine controls and measured the quantity and activity of the mitochondrial proteins complex IV and complex V. In addition, we evaluated the same measures in isolated plasma NDEVs by selective immunoaffinity capture targeting L1CAM from a separate cohort of eight FMR1 premutation carriers and four age‐matched controls.ResultsLower complex IV and V quantity and activity were observed in the cerebellum of FXTAS patients compared to controls, without any differences in total mitochondrial content. No patient‐control differences were observed in the frontal cortex. In NDEVs, FMR1 premutation carriers compared to controls had lower activity of Complex IV and Complex V, but higher Complex V quantity.InterpretationQuantitative and functional abnormalities in mitochondrial electron transport chain complexes IV and V seen in the cerebellum of patients with FXTAS are also manifest in plasma NDEVs of FMR1 premutation carriers. Plasma NDEVs may provide further insights into mitochondrial pathologies in this syndrome and could potentially lead to the development of biomarkers for predicting symptomatic FXTAS among premutation carriers and disease monitoring.
Fuzzy finite‐time adaptive control of switched nonlinear systems with input nonlinearities
Authors: Wang Huanqing , Tong Miao 
Published: May 2024

SummaryThis article addresses the fuzzy finite‐time command filtering tracking control problem for switched nonlinear systems with input nonlinearities via using backstepping technique. An equivalent transformation method is proposed for the purpose of handling the impediment problem caused by the nonlinearity of control input. Finite‐time command filtering control technology can solve the “explosion of complexity” issue, which is caused by the multiple derivation of virtual controllers appeared in the classic backstepping control. A filtering compensation scheme is developed to reduce the filtering error. By combining the fuzzy logic system's approximation ability and the finite‐time theory, a new fast convergence adaptive control scheme is proposed so that the output of the system can converge to a small area near the desired signal and the boundedness of all signals of the controlled system can be assured in finite time. Finally, a simulation example successfully verifies the feasibility of the developed control scheme.
Probability‐guaranteed encoding–decoding‐based state estimation for delayed memristive neutral networks with event‐triggered mechanism
Authors: Hu Chen , Zhang Shuhua , Zhao Hongyuan , Ma Lifeng , Guo Jian 
Published: May 2024

SummaryThis article handles the probability‐guaranteed state estimation problem for a class of nonlinear memristive neural networks (MNNs) by using an event‐triggered mechanism. Both time‐varying delays and incomplete measurements are considered in the MNNs dynamics. To mitigate the impact of limited communication bandwidth, a communication protocol is proposed that incorporates an encoding–decoding technique in addition to an event‐triggered scheme. The aim is to devise a state estimator that can estimate the states of MNNs, ensuring that the state estimation error falls within the required ellipsoidal area with a desired chance. We obtain sufficient conditions for the feasibility of the addressed problem, where the requested gains can be found iteratively by solving certain convex optimization problems. On the basis of the proposed framework, some issues are further presented to determine locally optimal estimator parameters according to different specifications. Finally, we utilize an illustrative numerical example to show the validity of our provided theoretical results.
Enhancement of Phase Stability and Thermoelectric Performance of Meta‐Stable AgSbTe2 by Thermal Cycling Process
Authors: Kim Jin Hee , Yun Jae Hyun , Cha Seunghun , Byeon Seokyeong , Park Junyoung , Jin Hyungyu , Kim Sujin , Kim Sung‐Jin , Park JongHo , Jang Jeongin , Park SuDong , Rhyee Jong‐Soo 
Published: May 2024

AbstractThermoelectric materials are crucial components in thermoelectric devices employed for environmentally friendly solid‐state cooling and waste heat recovery, demanding not only high performance but also superior thermal or phase stability. The high‐performance thermoelectric material AgSbTe2 encounters challenges when utilized in thermoelectric modules due to the precipitation of Ag2Te, resulting in both thermally unstable characteristics and diminished performance. In this study, a thermal cycling process is employed to enhance the thermal stability and thermoelectric performance of AgSbTe2. Through thermal cycling, secondary phases of AgSbTe2 are made uniform, and the undesired Ag2Te is substituted with Sb2Te3 using an optimized thermal cycling process. As a result, the thermal stability of AgSbTe2 is enhanced due to its meta‐stable state, with <5% variance in thermoelectric figure of merit (ZT) measurements, and the ZT value is raised from 0.8 to 1.7 at 643 K through the optimized thermal cycling. The findings indicate that thermal cycling is an effective strategy for enhancing the thermal stability and thermoelectric performance of AgSbTe2, presenting a novel approach for achieving uniform secondary phases in materials with phase separation or phase change characteristics.
Low‐Temperature Deposited Amorphous Poly(aryl ether ketone) Hierarchically Porous Scaffolds with Strontium‐Doped Mineralized Coating for Bone Defect Repair
Authors: Sun Tianze , Huang Huagui , Zhao Yantao , Li Zhonghai , Wang Honghua , Zhou Guangyuan 
Published: May 2024

AbstractIn recent years, the demand for clinical bone grafting has increased. As a new solution for orthopedic implants, polyether ether ketone (PEEK, crystalline PAEK) has excellent comprehensive performance and is practically applied in the clinic. In this research, a noteworthy elevated scheme to enhance the performance of PEEK scaffolds is presented. The amorphous aggregated poly (aryl ether ketone) (PAEK) resin is prepared as the matrix material, which maintains high mechanical strength and can be processed through the solution. So, the tissue engineering scaffolds with multilevel pores can be printed by low‐temperature deposited manufacturing (LDM) to improve biologically inert scaffolds with smooth surfaces. Also, the feature of PAEK's solution processing is profitable to uniformly add the functional components for bone repair. Ultimately, A system of orthopedic implantable PAEK material based on intermolecular interactions, surface topology, and surface modification is established. The specific steps include synthesizing PAEK that contain polar carboxyl structures, preparing bioinks and fabricating scaffolds by LDM, preparation of scaffolds with strontium‐doped mineralized coatings, evaluation of their osteogenic properties in vitro and in vivo, and investigation on the effect and mechanism of scaffolds in promoting osteogenic differentiation. This work provides an upgraded system of PAEK implantable materials for clinical application.