bluuebunny/crossref_metadata_2025_split huggingface dataset:
Alleviation of Immunologic Contact Urticaria and Mast Cell Degranulation by Myricetin
Authors: Staff Editorial 
Published: May 2024

Myricetin is a flavonoid compound found in various plants, such as berries, fruits, vegetables, and medicinal herbs. It has been studied for its potential health benefits, including its effects on immunologic contact urticaria and mast cell degranulation. Hu et al investigated the impact of myricetin and found that it may alleviate immunologic contact urticaria and mast cell. Immunologic contact urticaria is a type of allergic reaction that occurs when the skin comes into contact with certain allergens. It is characterized by the development of hives (urticarial lesions) and symptoms such as itching, redness, and swelling. The study investigated the effect of myricetin on immunologic contact urticaria using in vitro and in vivo models. Myricetin was chosen based on its known anti-inflammatory and antioxidant properties. The PI3K (phosphoinositide 3-kinase)/Akt (protein kinase B)/NF-κB (nuclear factor kappa-light-chain-enhancer of activated B cells) pathway is a signaling pathway involved in various cellular processes, including inflammation. Activation of this pathway is associated with mast cell degranulation and the release of pro-inflammatory mediators. The results of the study demonstrated that myricetin treatment attenuated immunologic contact urticaria and mast cell degranulation. Myricetin was found to inhibit the activation of the PI3K/Akt/NF-κB pathway, leading to reduced mast cell degranulation and decreased release of inflammatory mediators. Myricetin significantly inhibited PLCγ1, Akt, NF-κB, and p38 phosphorylation. These findings suggest that myricetin may have potential as a therapeutic agent for the management of immunologic contact urticarial and other allergic conditions. Phytother Res. 2023 May;37(5):2024-2035. doi: 10.1002/ptr.7726.
Medicinal Remedies for the Treatment of Methicillin Resistant Staphylococcus Aureus
Authors: Saleem Nida , Chen Yu-Cheng 
Published: May 2024

Antimicrobial resistance has led to the rise of formidable microbes like methicillin-resistant Staphylococcus aureus (MRSA). This infection can be acquired at the hospital and in a community, making the search for efficient treatment critical, given the rise in inefficacy of conventional treatments such as vancomycin. Phytocompounds can offer protection against these threats. They not only have the ability to kill MRSA but also enhance its susceptibility to previously ineffective antimicrobial agents. Plant-derived anti-MRSA agents can produce therapeutic effects comparable to some conventional treatments, and in some cases, they may even outperform an antibiotic. This article provided many examples of botanical compounds that have proven potent agents against MRSA in both in vitro and in vivo studies. These compounds achieve these effects by inhibiting the resistance mechanisms in MRSA, breaking down its defenses, making it vulnerable, and eventually killing it. Many of these compounds are inherently bactericidal; however, they may produce a synergistic response when combined with allopathic antibiotics. For example, plumbagin, from Plumbago zeylanica, not only disrupts MRSA cell wall morphology, eliciting cytoplasmic changes but also produces a synergistic effect with ciprofloxacin and piperacillin. Moreover, honokiol and magnolol glycosides, from Magnolia officinalis, reversed the quintessential resistance of MRSA by repressing genes, responsible for resistance development. The possibilities are indeed endless, but further research and financial investments are required for proper drug development.
MAPK/ERK and NF-κB Signaling Pathways Mediate Attenuation of Psoriasis by Punicalagin
Authors: Staff Editorial 
Published: May 2024

Psoriasis is a chronic autoimmune skin disorder characterized by the rapid and excessive growth of skin cells. It is a non-contagious condition that results in the formation of thick, red, and scaly patches on the skin surface. Psoriasis can affect various parts of the body and is often associated with other health issues. Wang and colleagues explored the impact and molecular mechanism of punicalagin (PU) on M5-stimulated keratinocyte cell lines and imiquimod (IMQ)-induced psoriasis-like skin inflammation in BABL/c mice. Their findings reveal that several indicators of psoriasis and its severity such as splenomegaly, IMQ-induced abnormal epidermal proliferation, CD4+ T-cell infiltration, and inflammatory factor expression were abrogated by PU-enriched pomegranate extract at dosages of 150 and 250 mg/kg/day. The expression levels of pro-inflammatory cytokines, such as IL-1β, IL-1α, IL-6, IL-8, TNF-α, IL-17A, IL-22, IL-23A, and reactive oxygen species (ROS) were also decreased. This was followed by the inhibition of keratinocyte proliferation in the M5-stimulated cell line model of inflammation. This keratinocyte proliferation inhibition is believed to be mediated through the inhibition of mitogen-activated protein kinases/extracellular regulated protein kinases (MAPK/ERK) and nuclear factor kappa B (NF-κB) signaling pathways. Their findings suggest that PU may serve as a promising nutritional intervention for psoriasis by ameliorating cellular oxidative stress and inflammation. Phytother Res. 2023 Nov 27. doi: 10.1002/ptr.8071.
Experiencia de la facilitación y tutoría en la pasantía interinstitucional en las Carreras de Psicología Clínica y Psicología, de la Universidad Abierta Para Adultos.
Authors: Cross Marte Evaleidi , Ramos Yngrid , Puentes Puentes Úrsula 
Published: May 2024

Se presenta el análisis de una Experiencias de Facilitación y Tutoría docente en las Prácticas Profesionales (Pasantía), durante el trimestre abril-junio del año 2022. La práctica profesional es determinante para consolidar en los participantes las competencias logradas y demostrar los aprendizajes teóricos y prácticos adquiridos durante su formación. El objetivo de esta investigación fue sistematizar la experiencia, de la pasantía interinstitucional, de acuerdo a la percepción de los participantes. Se emplearon como métodos: el análisis y síntesis, el estudio documental y la técnica de encuesta, en línea. En conclusión, se evidenció la satisfacción de los pasantes en cuanto al cumplimiento de sus expectativas y se fortalecieron las competencias profesionales declaradas en los planes de estudio, mediante el uso de estrategias metodológicas activas.
Peningkatan Kemampuan Membuat Perangkat Pembelajaran Inovatif Mahasiswa PPG Dalam Jabatan Kategori I Angkatan III, Dengan Penguatan Mata Kuliah Pendalaman Materi, dan Pengembangan Perangkat Pembelajaran IKIP Saraswati Tahun Akademik 2023/2024
Authors: Dian Permana Dewi Ni Wayan , Ni Made Serma Wati  , I Made Sudiana  
Published: May 2024

Penelitian ini bertujuan untuk meningkatkan kemampuan mahasiswa dalam penyusunan perangkat pembelajaran inovatif dengan penguatan mata kuliah pendalaman materi dan pengembangan perangkat pembelajaran. Metode penelitian yang digunakan adalah penelitian eksplorasi. Subyek penelitian yang digunakan adalah mahasiswa PPG Dalam Jabatan Kategori I Angkatan III IKIP Saraswati Tahun Akademik 2023/2024 sebanyak 9 orang. Data penelitian berupa kemampuan pembuatan perangkat pembelajaran diperoleh dengan instrumen penilaian yang berupa lembar observasi. Tehnik analisis data dengan analisa kualitatif. Dari pembelajaran penguatan mata kuliah pendalaman materi dan pengembangan perangkat pembelajaran diperoleh hasil terjadi peningkatan nilai rata-rata untuk kemampuan penyusunan Perangkat Pembelajaran 75, 42 menjadi 85.64 sehingga mengalami peningkatan sebesar 10,22 atau sebesar 13,5 %. Dengan demikian dapat disimpulkan bahwa penguatan mata kuliah pendalaman materi dan pengembangan perangkat pembelajaran dapat meningkatkan kemampuan mahasiswa dalam penyusunan perangkat pembelajaran inovatif
Exploring Student Utilization of Google Workspace for Education using Technology Acceptance Model at Nueva Ecija University of Science and Technology Santo Domingo Off-Campus
Authors: Agustin Noel , Gabay Paul John V. , Viloria Jr. Eduardo 
Published: May 2024

Google Workspace for Education, formerly GSuite for Education, is the term used for cloud-based services tailored by Google to educational institutions. Many higher education institutions take advantage of its free subscription in aid of improving the teaching-learning process. While many studies have found Google tools very useful for teachers, research on the utilization and acceptance of the students towards the use of Google Workspace for Education has not been examined yet. Hence, the attempt for this research. This study utilized the Technology Acceptance Model as its framework. Using 18 four-point Likert scales, the data were collected through an online questionnaire with 175 respondents. Pearson’s Correlation was used to assess the relationship among the variables in the TAM’s framework. The results showed a strong positive correlation in the students perceived ease of use and perceived usefulness to behavioral intention to use which also correlates to its actual use. The results of the study support various colleges and universities in leveraging the integration of Google Workspace for Education due to the high level of students’ acceptance in this technological infrastructure.
Perancangan UI/UX Aplikasi Manajemen Penyewaan Fasilitas Olahraga Di Kota Pontianak Dengan Metode User Centered Design
Authors: Natasha Azzahra Aprillia  , Hengky Anra  , Khairul Hafidh  
Published: May 2024

Masyarakat saat ini mulai sering memanfaatkan fasilitas olahraga di daerahnya untuk berolahraga, khususnya di Kota Pontianak. Keinginan pemerintah Kota Pontianak mewujudkan Pontianak menjadi Sport City selaras dengan penelitian ini. Perancangan desain UI/UX aplikasi ini memiliki tujuan yaitu menghasilkan desain yang dapat diterima dan memberikan kenyamanan pada pengguna akhir. Pembuatan aplikasi penyewaan fasilitas olahraga dapat menunjang tujuan pemerintah Kota Pontianak. Penelitian ini menggunakan metode User Centered Design (UCD) yang memiliki empat tahapan utama yaitu specify context of use, specify user requirements, design solutions, dan evaluate against requirements. Penggunaan metode user centered design cocok dalam penelitian ini karena proses perancangan user interface dan user experience yang berfokus pada pengguna akhir. Perancangan user interface dan user experience menjadi sebuah hal penting karena inti dari sebuah pembuatan aplikasi adalah memberikan pengalaman yang mudah dan solusi kepada pengguna. Setelah dilakukan analisis dan perancangan, maka didapat hasil akhir desain sesuai dengan kebutuhan dan keinginan calon pengguna. Hasil skor usability testing pun masuk dalam kategori “high” dengan tools maze dan kategori “excellent” dengan kuesioner SUS sebesar 86,5. Berdasarkan hasil akhir pengujian membuktikan bahwa hasil penelitian ini dapat diterima dan mudah dipahami oleh calon pengguna
Editorial
Authors: León Gomnzález Jorge Luis 
Published: May 2024

Estimados lectores:La Comisión Económica para América Latina y el Caribe es el organismo de la Organización de las Naciones Unidas responsable de promover el desarrollo económico y social de América Latina y el Caribe. En sus estudios sobre la región reconoce que las trayectorias tecnológicas son inseparables de las del empleo y la producción; de manera que la economía de cada país depende de la capacidad que tenga para aplicar conocimientos y disminuir la brecha tecnológica. En la región existen algunos avances en los indicadores del esfuerzo innovador y el acceso a la tecnología, pero aún es débil el posicionamiento en cuanto a la capacidad para absorber conocimientos en los paradigmas tecnológicos que impacten los sistemas productivos, se disminuyan costos, exista transformación social y se reduzca el índice de pobreza.A partir de esto es fundamental para cada país reorientar la Ciencia, la Tecnología y la Innovación en función de los tres objetivos de crecimiento económico, inclusión social y sostenibilidad ambiental planteados en los Objetivos de Desarrollo Sostenible y la Agenda 2030 para el Desarrollo Sostenible.Estos son algunos de los retos a los que se enfrenta nuestra región y a cuya solución se intenta solucionar con investigaciones aplicadas y promover con este número; sin dejar de reconocer que existe la necesidad de la identificación de políticas públicas que permitan transitar por senderos de desarrollo más inclusivos y sostenibles.
A Detailed Physical Explanation of an Aircraft Flutter Mechanism
Authors: Siqueira Luiz Felipi Ribeiro , Sousa Marcelo Santiago de , Cardoso-Ribeiro Flávio Luiz , Junior Sebastião Simões da Cunha 
Published: May 2024

Each dynamic mode (aeroelastic) is made up of torsional and rotational movements. These two movements in each mode were dissociated and the phase, amplitude, damping and frequency of each of these movements were analyzed. The structural resistances of torsion and bending, as well as the bending movement itself, have a damping effect and torsion has a destabilizing effect on the oscillations (if the centre of pressure is ahead of the flexural axis). After a certain speed, bending becomes out of phase with the applied forces. At this point, the bending has an amplifying effect on the oscillations and only the structural stiffness dampens the movement. From the speed at which the bending movement is out of phase with the applied aerodynamic loads, the damping of the mode decreases with speed, until flutter occurs. The type of analysis presented here was only possible due to the dissociation of torsion and bending movements in each mode. This is a novelty of this article. And this dissociation was made possible due to the use of the strain-based formulation, also called here as methodology NFNS_s (Non Linear Flight Dynamics – Non Linear Structural Dynamics – strain based formulation). The use of this methodology for this type of analysis was another contribution. The article presents the proposal of a new way of analyzing the aeroelastic stability of aircraft.
Chemical Modification and Denaturation Effects on the Hemagglutinating Activity of Two Pterocarpus Species Seeds Lectins
Authors: Folowosele Morenikeji Tolulope , Odekanyin Oludele Olayemi , Adefila Adenike Oluwaseun , Oyepitan Sinaola Praise , Owolabi Eniola Racheal , Alobaloye Ayomide Ifeoluwa 
Published: May 2024

Aims: Pterocarpus osun and Pterocarpus soyauxii seeds lectins were subjected to various chemical modifications in order to detect the amino acid residues involved in their hemagglutinating and sugar-binding activities.
Methodology: The lectins were purified using salt precipitation and size exclusion chromatography. Hemagglutinating activity and sugar specificity of the lectins were also established. Chemical modification of arginine was done using phenylglyoxal hydrate, and 5,5- dithiobis-(2-nitrobenzoic acid) (DTNB) was used to modify cysteine. Phenylmethylsulfonyl fluoride (PMSF) was employed for serine modification and tryptophan residue was modified with N-bromosuccinimide (NBS). Denaturants effects on the hemagglutinating activity were carried out with chaotropic agents, acid, disulphide bridge reducer and cross-linker agent.
Results: Pterocarpus osun seeds lectin is mannose specific while Pterocarpus soyauxii seeds lectin is galactose/lactose-binding lectin. Hemagglutinating activities of the two lectins were completely lost when tryptophan residue was modified with NBS and the loss was reversed by dialysis. Modifications of Cysteine, Arginine and Serine have no effect on the hemagglutinating activity of P. osun lectin. Nevertheless, the modifications of same amino acids slightly reduced the activity of P. soyauxii lectin, which dialysis and prolonged incubation were able to overturn. Mannose was found to bind and inhibit hemagglutinating activity of P. osun lectin in the presence of various modifiers but galactose and lactose could not inhibit the hemagglutinating activity of P. soyauxii lectin in the presence of modifiers. All denaturants employed significantly affected the hemagglutinating activity of the two lectins. However, the effects were reversible except for P. osun lectin denatured with 8M urea.
Conclusion: The results revealed that tryptophan residue is essential for hemagglutinating activity of the Pterocarpus species seeds lectins studied in this research. Cysteine, Arginine and Serine are also needed for sugar binding by P. soyauxii lectin but not so important in P. osun sugar binding ability.
Computational investigation of the mechanisms of particle separation and “fish‐hook” phenomenon in hydrocyclones
Authors: Wang B. , Yu A. B. 
Published: November 2009

AbstractThe motion of solid particles and the “fish‐hook” phenomenon in an industrial classifying hydrocyclone of body diameter 355 mm is studied by a computational fluid dynamics model. In the model, the turbulent flow of gas and liquid is modeled using the Reynolds Stress Model, and the interface between the liquid and air core is modeled using the volume of fluid multiphase model. The outcomes are then applied in the simulation of particle flow described by the stochastic Lagrangian model. The results are analyzed in terms of velocity and force field in the cyclone. It is shown that the pressure gradient force plays an important role in particle separation, and it balances the centrifugal force on particles in the radial direction in hydrocyclones. As particle size decreases, the effect of drag force whose direction varies increases sharply. As a result, particles have an apparent fluctuating velocity. Some particles pass the locus of zero vertical velocity (LZVV) and join the upward flow and have a certain moving orbit. The moving orbit of particles in the upward flow becomes wider as their size decreases. When the size is below a critical value, the moving orbit is even beyond the LZVV. Some fine particles would recircuit between the downward and upward flows, resulting in a relatively high separation efficiency and the “fish‐hook” effect. Numerical experiments were also extended to study the effects of cyclone size and liquid viscosity. The results suggest that the mechanisms identified are valid, although they are quantitatively different. © 2009 American Institute of Chemical Engineers AIChE J, 2010
Do 5HTTLPR and stress interact in risk for depression and suicidality? Item response analyses of a large sample
Authors: Coventry William L. , James Michael R. , Eaves Lindon J. , Gordon Scott D. , Gillespie Nathan A. , Ryan Leanne , Heath Andrew C. , Montgomery Grant W. , Martin Nicholas G. , Wray Naomi R. 
Published: November 2009

AbstractThe reported interaction between the length polymorphism (5HTTLPR) in the serotonin transporter gene (SLC6A4) and stressful life events on depression has led to many attempts to replicate but with inconsistent results. This inconsistency may reflect, in part, small sample size and the unknown contribution of the long allele SNP, rs25531. Using a large twin sample of 3,243 individuals from 2,230 families aged 18–95 years (mean = 32.3, SD = 13.6) we investigate the interaction between 5HTTLPR (subtyped with SNP rs25531) and stressful events on risk of depression and suicidality using both ordinal regressions and item response theory analyses. Participants reported via mailed questionnaire (82% response rate) both stressful events in the preceeding 12 months and symptoms of depression. Stressful events were defined as “personal” (affecting the individual), or “network” (affecting close family or friends). One to 10 years later (mean = 4.2 years), participants completed a comprehensive clinical psychiatric telephone interview (83% response rate) which assessed DSM‐IV major depression and ideation of suicidality. Self‐reports of depression and an increase in depression/suicidality assessed by clinical interview are significantly associated with prior personal events (P < 0.001) after controlling for age and sex. However, they are inconsistently associated with prior network events (ranging, ns to P < 0.01) and are not significantly associated with any of the genotype main effects (5HTTLPR, 5HTTLPR + rs25531) or interactions (stress × genotype). We find no evidence to support the hypothesis of any 5HTTLPR genotype by stress interaction. © 2009 Wiley‐Liss, Inc.
Male and female range use in a group of white‐bellied spider monkeys (Ateles belzebuth) in Yasuní National Park, Ecuador
Authors: Spehar Stephanie N. , Link Andres , Di Fiore Anthony 
Published: November 2009

AbstractSpider monkeys (Ateles sp.) live in a flexible fission–fusion social system in which members of a social group are not in constant association, but instead form smaller subgroups of varying size and composition. Patterns of range use in spider monkeys have been described as sex‐segregated, with males and females often ranging separately, females utilizing core areas that encompass only a fraction of the entire community range, and males using much larger portions of the community range that overlap considerably with the core areas of females and other males. Males are also reported to use the boundary areas of community home ranges more often than females. Spider monkeys thus seem to parallel the “male‐bonded” patterns of ranging and association found among some groups of chimpanzees. Over several years of research on one group of spider monkeys (Ateles belzebuth) in Yasuní National Park, Ecuador, we characterized the ranging patterns of adult males and females and evaluated the extent to which they conform to previously reported patterns. In contrast to ranging patterns seen at several other spider monkey sites, the ranges of our study females overlapped considerably, with little evidence of exclusive use of particular areas by individual monkeys. Average male and female home range size was comparable, and males and females were similar in their use of boundary areas. These ranging patterns are similar to those of “bisexually bonded” groups of chimpanzees in West Africa. We suggest that the less sex‐segregated ranging patterns seen in this particular group of spider monkeys may be owing to a history of human disturbance in the area and to lower genetic relatedness between males, highlighting the potential for flexibility some aspects of the spider monkeys' fission–fusion social system. Am. J. Primatol. 72:129–141, 2010. © 2009 Wiley‐Liss, Inc.