bluuebunny/crossref_metadata_2025_split huggingface dataset:
Changes in thoracic radio density after living donor liver transplantation
Authors: Miki Atsushi , Sakuma Yasunaru , Sanada Yukihiro , Watanabe Jun , Onishi Yasuharu , Okada Noriki , Horiuchi Toshio , Omameuda Takahiko , Teratani Takumi , Lefor Alan K. , Kitayama Joji , Sata Naohiro 
Published: May 2024

AbstractBackgroundThe outcomes after liver transplantation have greatly improved, which has resulted in greater focus on improving non‐hepatic outcomes of liver transplantation. The present study aimed to evaluate thoracic spine radio density in children and adolescents after liver transplantation.MethodsA total of 116 patients who underwent living donor liver transplantation were retrospectively analyzed. The radio density at the eleventh thoracic vertebra was measured using computed tomography scan performed preoperatively then annually for 5 years postoperatively and subsequently every 2 or 3 years.ResultsThe mean thoracic radio density of male recipients of male grafts had the lowest values during the study. The radio density of patients receiving a graft from a female donor was higher than in recipients with grafts from males. Total mean radio density decreased for first 5 years postoperatively and then increased. Changes in radio density were equally distributed in both steroid withdrawal and no steroid withdrawal groups for 5 years, after which patients with steroid withdrawal had a greater increase. Changes in radio density were equally distributed in both the steroid withdrawal and no steroid withdrawal groups up to age 20, after which patients in the steroid withdrawal group had a greater increase.ConclusionsGender differences may affect the outcome of radio density changes after transplantation. Given the moderate association between thoracic radio density and bone mineral density in skeletally mature adults and further studies are needed to validate this relationship between thoracic radio density and bone mineral density changes in pediatric liver transplantation.
Swedish translation and cultural adaptation of the scored Patient‐Generated Subjective Global Assessment (PG‐SGA©)—A validated tool for screening and assessing malnutrition in clinical practice and research
Authors: Lindström Rebecca , Orrevall Ylva , Belqaid Kerstin , McGreevy Jenny , Ottenblad Anna , Rothenberg Elisabet , Slinde Frode , Ottery Faith D. , Jager‐Wittenaar Harriët , Einarsson Sandra 
Published: May 2024

AbstractIntroductionThe scored Patient‐Generated Subjective Global Assessment (PG‐SGA©) is a validated tool for the screening, assessment and monitoring of malnutrition, and triaging of interventions. It contains a patient‐generated component and a healthcare professional (HCP)‐generated component.AimTo translate the PG‐SGA into Swedish, assess the linguistic and content validity of the Swedish version, and ensure conceptional, semantic and operational equivalence to the original English PG‐SGA.MethodsIn line with the methodology used in previously translated and culturally adapted versions, the standardised 10‐step process suggested by the International Society for Health Economics and Outcomes Research (ISPOR) was followed. In step 7, a cross‐sectional study targeting patients n = 51 and HCPs n = 52 was performed at a university hospital in Sweden. Using separate questionnaires, patients assessed the patient component and HCPs, the professional component regarding perceived comprehensibility and difficulty (linguistic validity). The HCPs also assessed perceived relevance (content validity) of all items on the PG‐SGA. Item indices for comprehensibility (I‐CI), difficulty (I‐DI) and content validity (I‐CVI) were calculated and averaged into scale indices (S‐CI, S‐DI and S‐CVI). Cut‐off standards for item and scale indices were used as reference.ResultsThe Swedish version of the PG‐SGA rated excellent for comprehensibility (S‐CI 0.96) and difficulty (S‐DI 0.93) for the patient component. The professional component rated acceptable for comprehensibility (S‐CI 0.89) and below acceptable for difficulty (S‐DI 0.70), with the physical examination rated most difficult (I‐DI 0.39 to 0.69). Content validity for the full Swedish PG‐SGA was rated excellent (S‐CVI 0.94).ConclusionThe patient component was considered clear and easy to complete. The full Swedish PG‐SGA was considered relevant by HCPs for screening and assessment of malnutrition. Due to perceived difficulty with the physical examination, training of Swedish HCPs in using the PG‐SGA is essential before implementing the professional component into clinical practice or research.
Desmantelando Estereótipos: A Prática Interseccional da Corte Interamericana de Direitos Humanos
Authors: Macedo Lima Porto Matheus , De Ávila Flávia 
Published: May 2024

Qual é o papel que um tribunal regional de direitos humanos possui no enfrentamento dos estereótipos? Com base nessa indagação, o objetivo deste trabalho é analisar como a Corte Interamericana de Direitos Humanos tem incorporado, ao longo dos anos, a interseccionalidade enquanto ferramenta teórica e metodológica na construção de suas decisões quando estão postas situações de desigualdade estrutural em que os estereótipos foram decisivos para que direitos fossem violados. O principal argumento apresentado é de que, ao identificar e reconhecer os estereótipos, o tribunal busca desmantelá-los, promovendo justiça como antissubordinação e emancipação. Em suma, ao desvelar sistemas de poder confluentes que produzem locais sociais de opressão para determinados grupos, a perspectiva interseccional fornece elementos para a produção de decisões comprometidas com a ideia de uma justiça social que só é possível quando não amesquinha nenhum segmento da sociedade.
PALAVRAS-CHAVE: Estereótipos; Interseccionalidade; Perspectiva de Gênero; Corte Interamericana de Direitos Humanos.
Um Estudo Exploratório Sobre o Método Quantitativo em Casos de Abuso Sexual Infanto-Juvenil
Authors: De Lima Villarroel Camila Maria , Severi Fabiana Cristina 
Published: May 2024

A pesquisa busca analisar a (in)acessibilidade à justiça para crianças e adolescente vítimas do abuso sexual infanto-juvenil no Poder Judiciário. O trabalho buscará investigar o perfil das respostas judiciais nas comarcas do Tribunal de Justiça do Estado de São Paulo sobre abuso sexual infanto-juvenil entre 2010 e 2020 e o impacto do acesso à justiça para essas respostas. Para isso, determinamos como objetivo geral a análise, a partir de modelos de acesso à justiça, dos resultados obtidos por meio do estudo estatístico das variáveis indicadas pela literatura como importantes para entender o abuso sexual infanto-juvenil. Foi adotada a metodologia empírica pela análise centrada no estudo de variáveis a ser realizado por meio de regressão estatística em três etapas: apresentação do marco normativo e teórico, formulação do mapa conceitual e análise jurimétrica. Como resultado verificamos que a média de condenações é impactada em maior grau, ainda que de forma não significante estatisticamente, pela fase de desenvolvimento criança, gênero feminino em casos intrafamiliares. O grau de urbanização e o número de serviços especializados não indicaram impacto relevante para entender a média de condenações das comarcas. A conclusão do estudo indica a necessidade de implementação de atendimento especializados para crianças e adolescentes nas comarcas do interior com expertise para lidar com vítimas crianças do gênero feminino, além da necessidade do entendimento crítico não departamentalizado sobre o abuso sexual infanto-juvenil pela predominância de casos intrafamiliares.
PALAVRAS-CHAVE: Abuso Sexual; Crianças e Adolescentes; Acesso à Justiça; Jurimetria
(DE)Colonialidade Digital e a Airbnbinificação das Cidades
Authors: Gonçalves da Silva Lucas , Felix Nascimento Reginaldo 
Published: May 2024

: O presente artigo tem como objetivo analisar a influência do Airbnb nas cidades, explorando seus aspectos legais e sociais à luz do pensamento decolonial. Especificamente, busca-se identificar como o Airbnb contribui para a intensificação das desigualdades sociais caracterizadas pela colonialidade, as quais são promovidas pelo Direito de Propriedade e prejudicam populações de baixa renda. Adicionalmente, pretende-se diagnosticar como as discussões relacionadas ao Airbnb estão embasadas na Constituição Federal e propor soluções jurídicas alinhadas ao pensamento decolonial para enfrentar os desafios decorrentes da atuação do Airbnb nas cidades. O método utilizado é o hipotético-dedutivo, por meio de uma pesquisa qualitativa com abordagem temática histórico-evolutiva e dogmática, utilizando recursos bibliográficos e documentais. Em conclusão, a airbnbficação das cidades representa um risco para as populações mais pobres e para o uso comum dos espaços urbanos.

PALAVRAS-CHAVE: Airbnbficação das Cidades; Solidariedade e Alteridade; Direito à Cidade e Novas Tecnologias; Decolonialidade Digital; Locação e Airbnb
El Deber De Cuidado. Cosas Y Personas Abandonadas En El Léxico Constitucional Y En Las Prácticas De Justicia Del Antiguo Régimen
Authors: Buono Alessandro 
Published: May 2024

Basándose en un análisis de las fuentes normativas y los procedimientos judiciales de la Monarquía Española del Antiguo Régimen, este artículo propone una interpretación paralela de la gestión de cosas y personas abandonadas, partiendo de un principio fundamental que parece ser compartido en esta sociedad europea organizada bajo un principio corporativo: cada relación social conlleva una responsabilidad, entendida como el deber de responder ante algo o alguien, asumir la responsabilidad y cuidar cosas y personas. Desde esta ideología constitucional, en la que todo padre, dueño o administrador tenía la obligación de cuidar de sus posesiones y familiares, el soberano ‘supremo administrador y tutor’ podía reclamar una tutela universal sobre todas las personas y cosas dentro de su reino, asegurando que nadie quedara solo, aislado o estéril, y legitimando así su intervención como garante de la protección y reproducción del orden.

PALABRAS LLAVE: Soberano tutor, responsabilidad, cuidado, cosas y personas abandonadas.
Markoff–Lagrange spectrum of one‐sided shifts
Authors: Kaneko Hajime , Steiner Wolfgang 
Published: May 2024

AbstractFor the Lagrange spectrum and other applications, we determine the smallest accumulation point of binary sequences that are maximal in their shift orbits. This problem is trivial for the lexicographic order, and its solution is the fixed point of a substitution for the alternating lexicographic order. For orders defined by cylinders, we show that the solutions are ‐adic sequences, where is a certain infinite set of substitutions that contains Sturmian morphisms. We also consider a similar problem for symmetric ternary shifts, which is applicable to the multiplicative version of the Markoff–Lagrange spectrum.
Large deviations of the argument of the Riemann zeta function
Authors: Dobner Alexander 
Published: May 2024

AbstractLet . We prove an unconditional lower bound on the measure of the sets for . For , our bound has a Gaussian shape with variance proportional to . At the endpoint, , our result implies the best known ‐theorem for that is due to Tsang. We also explain how the method breaks down for given our current knowledge about the zeros of the zeta function. Conditionally on the Riemann hypothesis, we extend our results to the range .
Adaptive Functional Electrical Stimulation Delivers Stimulation Amplitudes Based on Real-Time Gait Biomechanics
Authors: Donlin Margo C. , Higginson Jill S. 
Published: May 2024

Abstract
Functional electrical stimulation (FES) is often used in poststroke gait rehabilitation to decrease foot drop and increase forward propulsion. However, not all stroke survivors experience clinically meaningful improvements in gait function following training with FES. The purpose of this work was to develop and validate a novel adaptive FES (AFES) system to improve dorsiflexor (DF) and plantarflexor (PF) stimulation timing and iteratively adjust the stimulation amplitude at each stride based on measured gait biomechanics. Stimulation timing was determined by a series of bilateral footswitches. Stimulation amplitude was calculated based on measured dorsiflexion angle and peak propulsive force, where increased foot drop and decreased paretic propulsion resulted in increased stimulation amplitudes. Ten individuals with chronic poststroke hemiparesis walked on an adaptive treadmill with adaptive FES for three 2-min trials. Stimulation was delivered at the correct time to the dorsiflexor muscles during 95% of strides while stimulation was delivered to the plantarflexor muscles at the correct time during 84% of strides. Stimulation amplitudes were correctly calculated and delivered for all except two strides out of nearly 3000. The adaptive FES system responds to real-time gait biomechanics as intended, and further individualization to subject-specific impairments and rehabilitation goals may lead to improved rehabilitation outcomes.
Analysis of clinical
Candida parapsilosis
isolates reveals copy number variation in key fluconazole resistance genes
Authors: Bergin Sean , Doorley Laura A. , Rybak Jeffrey M. , Wolfe Kenneth H. , Butler Geraldine , Cuomo Christina A. , Rogers P. David 
Published: May 2024

ABSTRACT

We used whole-genome sequencing to analyze a collection of 35 fluconazole-resistant and 7 susceptible
Candida parapsilosis
isolates together with coverage analysis and GWAS techniques to identify new mechanisms of fluconazole resistance. Phylogenetic analysis shows that although the collection is diverse, two persistent clinical lineages were identified. We identified copy number variation (CNV) of two genes,
ERG11
and
CDR1B
, in resistant isolates. Two strains have a CNV at the
ERG11
locus; the entire ORF is amplified in one, and only the promoter region is amplified in the other. We show that the annotated telomeric gene
CDR1B
is actually an artifactual
in silico
fusion of two highly similar neighboring
CDR
genes due to an assembly error in the
C. parapsilosis
CDC317 reference genome. We report highly variable copy numbers of the
CDR1B
region across the collection. Several strains have increased the expansion of the two genes into a tandem array of new chimeric genes. Other strains have experienced a deletion between the two genes creating a single gene with a reciprocal chimerism. We find translocations, duplications, and gene conversion across the
CDR
gene family in the
C. parapsilosis
species complex, showing that it is a highly dynamic family.
In a state of flux: new insight into the transport processes that maintain bacterial metal homeostasis
Authors: Kwiatos Natalia , Waldron Kevin J. 
Published: May 2024

ABSTRACT

A new study by Nies et al. (J Bacteriol 206:e00080-24, 2024,
https://doi.org/10.1128/jb.00080-24
) provides a rich, quantitative data set of zinc accumulation by cells of
Cupriavidus metallidurans
, including of mutant bacterial strains lacking import or efflux genes, and comparison of zinc accumulation by cells previously starved of metal with those of zinc-replete cells. The data surprisingly demonstrate the concomitant activity of both active metal import and metal efflux systems. They present a flow equilibrium model to describe zinc homeostasis in bacteria.
Characterization of virus‒host recombinant variants of the hepatitis E virus
Authors: Paronetto Olivia , Allioux Claire , Diméglio Chloé , Lobjois Lhorane , Jeanne Nicolas , Ranger Noémie , Boineau Jérôme , Pucelle Mélanie , Demmou Sofia , Abravanel Florence , Chapuy-Regaud Sabine , Izopet Jacques , Lhomme Sébastien 
Published: May 2024

ABSTRACT

Hepatitis E virus is a single-strand, positive-sense RNA virus that can lead to chronic infection in immunocompromised patients. Virus–host recombinant variants (VHRVs) have been described in such patients. These variants integrate part of human genes into the polyproline-rich region that could introduce new post-translational modifications (PTMs), such as ubiquitination. The aim of this study was to characterize the replication capacity of different VHRVs, namely, RNF19A, ZNF787, KIF1B, EEF1A1, RNA18, RPS17, and RPL6. We used a plasmid encoding the Kernow strain, in which the fragment encoding the S17 insertion was deleted (Kernow p6 delS17) or replaced by fragments encoding the different insertions. The HEV RNA concentrations in the supernatants and the HepG2/C3A cell lysates were determined via RT-qPCR. The capsid protein ORF2 was immunostained. The effect of ribavirin was also assessed. The HEV RNA concentrations in the supernatants and the cell lysates were higher for the variants harboring the RNF19A, ZNF787, KIF1B, RPS17, and EEF1A1 insertions than for the Kernow p6 del S17, while it was not with RNA18 or RPL6 fragments. The number of ORF2 foci was higher for RNF19A, ZNF787, KIF1B, and RPS17 than for Kernow p6 del S17. VHRVs with replicative advantages were less sensitive to the antiviral effect of ribavirin. No difference in PTMs was found between VHRVs with a replicative advantage and those without. In conclusion, our study showed that insertions did not systematically confer a replicative advantage
in vitro
. Further studies are needed to determine the mechanisms underlying the differences in replicative capacity.

IMPORTANCE

Hepatitis E virus (HEV) is a major cause of viral hepatitis. HEV can lead to chronic infection in immunocompromised patients. Ribavirin treatment is currently used to treat such chronic infections. Recently, seven virus–host recombinant viruses were characterized in immunocompromised patients. These viruses have incorporated a portion of a human gene fragment into their genome. We studied the consequences of these insertions on the replication capacity. We found that these inserted fragments could enhance virus replication for five of the seven recombinant variants. We also showed that the recombinant variants with replicative advantages were less sensitive to ribavirin
in vitro
. Finally, we found that the mechanisms leading to such a replicative advantage do not seem to rely on the post-translational modifications introduced by the human gene fragment that could have modified the function of the viral protein. The mechanisms involved in improving the replication of such recombinant viruses remain to be explored.
Stratigraphic and U-Pb zircon age constraints on the timing of the Yanliao Biota in northern China
Authors: Zou Zu-Yang , Ma Qiang , Xu Yi-Gang , Liu Liang , Xia Xiao-Ping , Yang Chuan-Mao 
Published: May 2024

Abstract
The Yanliao Biota from northern China is one of the most famous Mesozoic terrestrial lagerstätten in the world, with well-preserved fossil records in the Jurassic volcanic-sedimentary Ningcheng and Jianchang basins. However, the temporal evolution of the Yanliao Biota remains controversial, mainly due to the confusing stratigraphic framework and the unclear age of fossiliferous deposits in the Ningcheng basin. To address this issue, we carried out detailed field investigations and secondary ion mass spectrometry (SIMS) U-Pb age dating of zircons on fossiliferous and related strata in the southern part of the Ningcheng basin. The Jurassic infill of this area is composed of, in ascending order, fossil-bearing tuffaceous clastic rocks (unit 1), andesite and pyroclastic rocks (unit 2), fossil-bearing clastic rocks interlayered with minor volcanic rocks (unit 3), and andesite and pyroclastic rocks (unit 4). Integration of stratigraphic and geochronological data indicates that the Yanliao Biota in the Ningcheng basin appeared no later than ca. 163 Ma and lasted until ca. 156 Ma. A comparison with other analogous basins in northern China (e.g., the Luanping, Jianchang, and Beipiao basins) leads to the conclusion that the Yanliao Biota evolved in two phases and lasted for more than 11 m.y.: the first phase from ca. 167 Ma to ca. 163 Ma in the middle Bathonian to middle Callovian, followed by the second phase between ca. 161 Ma and ca. 156 Ma in the lower and middle Oxfordian.
A egiptomania e o orientalismo de D. Pedro II por seu retrato e diários egípcios
Authors: Paschoal Nina Ingrid Caputo 
Published: May 2024

Discutiremos os conceitos de egiptomania e orientalismo e como eles se adequam à figura e aos interesses de d. Pedro II. Para isso, serão mobilizados dois tipos de fontes: os diários de viagem e uma fotografia do imperador, ambos realizados em suas viagens ao Egito. Pelo emprego da análise do discurso, demonstraremos como as informações anotadas podem ser repositórios para a verificação dos dois fenômenos. Já a partir da fotografia, faremos a análise iconográfica e iconológica, tangenciando também a chegada da técnica ao Brasil, seu uso pelo monarca e, ainda, a forma pela qual ele se utilizou da imagem do Egito para construção de sua própria e na projeção de seu ideário político.
A questão do reconhecimento: Fanon e a dialética hegeliana
Authors: Silva Paulo César Andrade da 
Published: May 2024

Partindo do plano das atividades da “Década Internacional de Afrodescendentes”, proclamada pela Assembleia Geral da ONU (2015 a 2024), este artigo propõe refletir sobre o reconhecimento do sujeito colonial em duas dimensões: a) a negação do homem negro encenada na poesia de Cruz e Souza e Oswaldo de Camargo; b) o diálogo que Frantz Fanon estabelece com Hegel. Fanon adverte que o homem negro está fora do processo da história, porque é apresentado dentro do circuito fechado da consciência-de-si ou “em-si” e jamais como o estágio da consciência crítica de um “ser-para-si”, pois não lhe é dada a reciprocidade do reconhecimento.
Humanizar os legados feridos do passado colonial: o dever de pós-memória em Estranha Guerra de Uso Comum
Authors: Khan Sheila 
Published: May 2024

This work seeks to reflect on the wounded legacies of colonialism from a post memory perspective, that is, under the sign of an urgency to understand, humanize, and universalize the evils that resulted from the Portuguese experience in colonized African territories, namely, with regard to the traumas, silences and scars created by this overseas experience. To erase the past is, in the light of this pretense, a mistake. Therefore, the merit of this emerging paradigm of the study of memory highlights the historical will of a generation that, due to family proximity, seeks through processes of recognition and compassion to bring to the place of sorrow a more positive, understanding and fraternal light.