bluuebunny/crossref_metadata_2025_split huggingface dataset:
Functional Variants of Fc Gamma Receptor (FCGR2A) and FCGR3A Are Not Associated with Susceptibility to Systemic Sclerosis in a Large European Study (EUSTAR)
Authors: ALIZADEH BEHROOZ Z. , BROEN JASPER , RUEDA BLANCA , HESSELSTRAND ROGER , WUTTGE DIRK , SIMEON CARMEN , ORTEGO-CENTENO NORBERTO , GONZALEZ-GAY MIGUEL A. , PROS ANNA , HERRICK ARIANE , WORTHINGTON JANE , DENTON CHRISTOPHER , FONSECA CARMEN , RIEMEKASTEN GABRIELA , VONK MADELON C. , van den HOOGEN FRANK , GUIDUCCI SERENA , MATUCCI-CERINIC MARCO , SCORZA RAFAELLA , BERETTA LORENZO , AIRÓ PAOLO , COENEN MARIEKE , MARTIN JAVIER , KOELEMAN BOBBY P.C. , RADSTAKE TIMOTHY R.D.J. 
Published: June 2010

Objective.To investigate the possible role ofFCGR2A519A>G andFCGR3A559A>C functional polymorphisms in the genetic predisposition to susceptibility to systemic sclerosis (SSc) or clinical phenotype.Methods.A total of 1566 patients with SSc and 2271 geographically matched controls were included in our study. We analyzed the genotype and allele frequencies of theFCGR2A519A>G andFCGR3A559A>C functional variants in 6 independent European cohorts of white patients with SSc, and white controls. The cohorts comprised 165 Dutch patients with SSc and 1326 controls, 236 Spanish patients with SSc and 257 controls, 267 German patients with SSc and 270 controls, 202 Swedish patients with SSc and 261 controls, 416 Italian patients with SSc and 157 controls, and additionally 280 English patients with SSc. Genotyping was performed using Taqman 5′ allelic discrimination assay. The study reached a 99% power to detect the effect of a polymorphism at an OR of 1.3.Results.NeitherFCGR2A519A>G norFCGR3A559A>C was significantly associated with susceptibility to SSc. We did not find an association with specific disease phenotypes, limited or diffuse cutaneous involvement, autoantibody profiles, or pulmonary involvement.Conclusion.Our study strongly suggests the lack of a role for theFCGR2A519A>G andFCGR3A559A>C polymorphisms in SSc susceptibility or clinical phenotype in 6 independent European cohorts.
Quantifying Bone Marrow Edema in the Rheumatoid Cervical Spine Using Magnetic Resonance Imaging
Authors: SUPPIAH RAVI , DOYLE ANTHONY , RAI RAYLYNNE , DALBETH NICOLA , LOBO MARIA , BRAUN JÜRGEN , McQUEEN FIONA M. 
Published: June 2010

Objective.To determine the reliability and feasibility of a new magnetic resonance imaging (MRI) score to quantify bone marrow edema (BME), synovitis, and erosions in the cervical spine of patients with rheumatoid arthritis (RA); and to investigate the correlations among neck pain, clinical markers of RA disease activity, and MRI features of disease activity in the cervical spine.Methods.Thirty patients with RA (50% with neck pain) and a Disease Activity Score 28-joint count > 3.2 had an MRI scan of their cervical spine. STIR, VIBE, and T1-weighted postcontrast sequences were used to quantify BME. MRI scans were scored for total BME, synovitis, and erosions using a new scoring method developed by the authors and assessed for reliability and feasibility. Associations between neck pain and clinical markers of disease activity were investigated.Results.BME was present in 14/30 patients; 9/14 (64%) had atlantoaxial BME, 10/14 (71%) had subaxial BME, and 5/14 (36%) had both. Interobserver reliability for total cervical BME score was moderate [intraclass correlation coefficient (ICC) = 0.51]. ICC improved to 0.67 if only the vertebral bodies and dens were considered. There was no correlation between neck pain or clinical measures of RA disease activity and the presence of any MRI features including BME, synovitis, or erosions.Conclusion.Current RA disease activity scores do not identify activity in the cervical spine. An MRI score that quantifies BME, synovitis, and erosions in the cervical spine may provide useful information regarding inflammation and damage. This could alert clinicians to the presence of significant pathology and influence management.
Influence ofIL6Rrs8192284 Polymorphism Status in Disease Activity in Rheumatoid Arthritis
Authors: LAMAS JOSÉ RAMÓN , RODRÍGUEZ-RODRÍGUEZ LUIS , VARADÉ JEZABEL , LÓPEZ-ROMERO PEDRO , TORNERO-ESTEBAN PILAR , ABASOLO LYDIA , URCELAY ELENA , FERNÁNDEZ-GUTIÉRREZ BENJAMÍN 
Published: June 2010

Objective.To analyze the influence ofIL6Rrs8192284 polymorphism on the disease activity of rheumatoid arthritis (RA).Methods.Patients with RA (n = 281) were followed for a median of 4.2 years. A total of 1143 disease activity measurements using the 28-joint count Disease Activity Score (DAS28) were performed. A mixed-effect model was used to analyze the measurements.Results.A statistically significant interaction was observed betweenIL6Rrs8192284 polymorphism and the presence of anticyclic citrullinated peptide (anti-CCP) antibodies (p = 0.008). An inverse relationship between the polymorphism and DAS28 was observed depending on anti-CCP status.Conclusion.The anti-CCP status in patients with RA determines the association between theIL6Rrs8192284 polymorphism and disease activity.
Scale Characteristics and Mapping Accuracy of the US EQ-5D, UK EQ-5D, and SF-6D in Patients with Rheumatoid Arthritis
Authors: WOLFE FREDERICK , MICHAUD KALEB , WALLENSTEIN GENE 
Published: June 2010

Objective.To compare the US EQ-5D with the UK EQ-5D and the SF-6D in patients with rheumatoid arthritis (RA). To provide mappings for each of the scales based on clinical variables.Methods.We studied 12,424 patients with RA with 66,958 longitudinal observations using linear regression. In our mapping models we used the Health Assessment Questionnaire (HAQ) as a continuous predictor variable and as individual items. More complex models included the addition of a visual analog pain scale, the mood scale from the SF-36, and demographic and comorbidity covariates. We compared various models using root mean squared error (RMSE), in-sample and out-of-sample mean absolute error (MAE), and other measures of prediction accuracy and model fit.Results.At any level of clinical severity, the US EQ-5D always had a higher utility score than the UK EQ-5D; and overall, the US scores were 0.094 units higher. The best models explained 64% to 72% of variance in utility scores, with RMSE values of 0.07 (SF-6D), 0.11 (EQ-5D US), and 0.17 (UK EQ-5D). There was a substantial increase in predictive accuracy by using pain and mood as predictor variables in the mapping.Conclusion.The US EQ-5D differs from the UK version and from the SF-6D in mean scores and ranges. When determined by mapping, the US EQ-5D has a much lower prediction error than the UK EQ-5D. Simple mapping models that use HAQ and pain have acceptable error rates, although more complex models that include mood scores and individual HAQ items substantially improve predictive accuracy.
In vitro developmental toxicology assays: A review of the state of the science of rodent and zebrafish whole embryo culture and embryonic stem cell assays
Authors: Augustine‐Rauch Karen , Zhang Cindy X. , Panzica‐Kelly Julieta M. 
Published: June 2010

AbstractIn vitro developmental model systems have been an important tool for advancing basic research in the embryology and teratology fields. The rat and zebrafish embryo models have had broad utility in both fields for many decades. Furthermore embryonic stem cells, applied as a basic research tool, have broad applications across the development fields and many other fields including cancer, regeneration and epigenetic research. These models have historically been applied in mechanistic studies but were also considered promising for evaluating teratogenic potential of test substances. In recent years, in vitro teratogenicity assays have become an area of interest for supporting the 3 Rs (reduction, refinement, and replacement of animal use). Generation of such assays also provides a means to facilitate early assessment of test agents at a higher throughput without excessive use of animals. In this review, the three models are described with an emphasis of how they are being developed and/or refined to support teratogenicity assessment as screening tools. An overview of the state of the science and future directions are described. Birth Defects Research (Part C) 90:87–98, 2010. © 2010 Wiley‐Liss, Inc.
In honor of the Teratology Society's 50th anniversary: The role of Teratology Society members in the development and evolution of in vivo developmental toxicity test guidelines
Authors: Tyl Rochelle W. 
Published: June 2010

AbstractMembers of the Teratology Society (established in 1960) were involved in the first governmental developmental and reproductive toxicity testing guidelines (1966) by FDA following the thalidomide epidemic, followed by other national and international governmental testing guidelines. The Segment II (developmental toxicity) study design, described in rodents and rabbits, has evolved with additional enhanced endpoints and better descriptions, mechanistic insights, range‐finding studies, and toxico/pharmacokinetic ADME information (especially for pharmaceuticals). Society members were also involved in the development of the current screening assays and tests for endocrine disruptors (beginning in 1996) and are now involved with developing new testing guidelines (e.g., the extended one‐generation protocol), and evaluating the current test guidelines and new initiatives under ILSI/HESI sponsorship. New initiatives include ToxCast from the U.S. EPA to screen, prioritize, and predict toxic chemicals by high throughput and high‐content in vitro assays, bioinformation, and modeling to reduce (or eliminate) in vivo whole animal studies. Our Society and its journal have played vital roles in the scientific and regulatory accomplishments in birth defects research over the past 50 years and will continue to do so in the future. Happy 50th anniversary! Birth Defects Research (Part C) 90:99–102, 2010. © 2010 Wiley‐Liss, Inc.
Oxidative DNA damage and repair in teratogenesis and neurodevelopmental deficits
Authors: Wells Peter G. , McCallum Gordon P. , Lam Kyla C. H. , Henderson Jeffrey T. , Ondovcik Stephanie L. 
Published: June 2010

AbstractSeveral teratogenic agents, including ionizing radiation and xenobiotics such as phenytoin, benzo[a]pyrene, thalidomide, and methamphetamine, can initiate the formation of reactive oxygen species (ROS) that oxidatively damage cellular macromolecules including DNA. Oxidative DNA damage, and particularly the most prevalent 8‐oxoguanine lesion, may adversely affect development, likely via alterations in gene transcription rather than via a mutational mechanism. Contributions from oxidative DNA damage do not exclude roles for alternative mechanisms of initiation like receptor‐mediated processes or the formation of covalent xenobiotic–macromolecular adducts, damage to other macromolecular targets like proteins and lipids, and other effects of ROS like altered signal transduction. Even in the absence of teratogen exposure, endogenous developmental oxidative stress can have embryopathic consequences in the absence of key pathways for detoxifying ROS or repairing DNA damage. Critical proteins in pathways for DNA damage detection/repair signaling, like p53 and ataxia telangiectasia mutated, and DNA repair itself, like oxoguanine glycosylase 1 and Cockayne syndrome B, can often, but not always, protect the embryo from ROS‐initiating teratogens. Protection may be variably dependent upon such factors as the nature of the teratogen and its concentration within the embryo, the stage of development, the species, strain, gender, target tissue and cell type, among other factors. Birth Defects Research (Part C) 90:103–109, 2010. © 2010 Wiley‐Liss, Inc.
Predicting developmental toxicity through toxicogenomics
Authors: Daston George P. , Naciff Jorge M. 
Published: June 2010

AbstractGlobal analysis of gene expression in target cells or tissues in response to a toxicant holds significant promise for predictive toxicology. Toxicants elicit a characteristic pattern of gene expression that is dependent on mechanism of action. These mechanism‐specific transcript profiles can be used as the basis for predictive toxicology. Potential applications include prioritizing chemicals for testing and customizing testing approaches based on the chemical. Results that are useful in this predictive context can be obtained from animal or in vitro models. Gene expression analysis can also be used to elucidate the shape of the dose‐response curve at exposure levels below the no observed adverse effect level, an important need in risk assessment. In this review, we will illustrate each of these points using our research on estrogen and an estrogenic mode of action as a model for how to use gene expression data in a predictive way. Although gene expression in response to estrogens is tissue, life stage, and sex specific, it is feasible to identify transcript profiles that are diagnostic of this mode of action. Birth Defects Research (Part C) 90:110–117, 2010. © 2010 Wiley‐Liss, Inc.
Role of environmental factors in axial skeletal dysmorphogenesis
Authors: Alexander Peter G. , Tuan Rocky S. 
Published: June 2010

AbstractApproximately 1 in 1000 live births is afflicted with an axial skeletal defect. Although many of the known human teratogens can produce axial skeletal defects, the etiology of over half of the observed defects is unknown. The high morbidity associated with these defects demands that we continue to elucidate the mechanisms of axial skeletal teratogens. Advances in cell and molecular biology with respect to normal development and somitogenesis and the pathogenesis and mechanisms of teratogenesis are occurring at a tremendous rate. This allows teratologists and developmental toxicologists the opportunity to revisit old problems with new tools to elucidate common mechanisms between various environmental insults and discover novel targets that aid in the understanding of normal and pathogenic development of the spine. Birth Defects Research (Part C) 90:118–132, 2010. © 2010 Wiley‐Liss, Inc.
Palate morphogenesis: Current understanding and future directions
Authors: Greene Robert M. , Pisano M. Michele 
Published: June 2010

AbstractIn the past, most scientists conducted their inquiries of nature via inductivism, the patient accumulation of “pieces of information” in the pious hope that the sum of the parts would clarify the whole. Increasingly, modern biology employs the tools of bioinformatics and systems biology in attempts to reveal the “big picture.” Most successful laboratories engaged in the pursuit of the secrets of embryonic development, particularly those whose research focus is craniofacial development, pursue a middle road where research efforts embrace, rather than abandon, what some have called the “pedestrian” qualities of inductivism, while increasingly employing modern data mining technologies. The secondary palate has provided an excellent paradigm that has enabled examination of a wide variety of developmental processes. Examination of cellular signal transduction, as it directs embryogenesis, has proven exceptionally revealing with regard to clarification of the “facts” of palatal ontogeny—at least the facts as we currently understand them. Herein, we review the most basic fundamentals of orofacial embryology and discuss how functioning of TGFβ, BMP, Shh, and Wnt signal transduction pathways contributes to palatal morphogenesis. Our current understanding of palate medial edge epithelial differentiation is also examined. We conclude with a discussion of how the rapidly expanding field of epigenetics, particularly regulation of gene expression by miRNAs and DNA methylation, is critical to control of cell and tissue differentiation, and how examination of these epigenetic processes has already begun to provide a better understanding of, and greater appreciation for, the complexities of palatal morphogenesis. Birth Defects Research (Part C) 90:133–154, 2010. © 2010 Wiley‐Liss, Inc.
2,3,7,8,12,13‐Hexaaryltruxenes: An ortho‐Substituted Multiarm Design and Microwave‐Accelerated Synthesis toward Starburst Macromolecular Materials with Well‐Defined π Delocalization
Authors: Lai Wen‐Yong , Xia Ruidong , Bradley Donal D. C. , Huang Wei 
Published: June 2010

AbstractWe present herein a novel design and the efficient synthesis towards a “homogeneous” starburst fluorene system based on the novel 2,3,7,8,12,13‐hexaaryltruxene scaffold. Controlled microwave heating provides a facile and powerful approach for each step in the synthesis of these bulky materials with large steric hindrance, suggesting an avenue to access structurally well‐defined complex organic semiconductors (OSCs) rapidly and conveniently with high yield and purity. The resulting materials exhibited good thermal stability and an excellent glassy structure as revealed by thermogravimetric analysis (TGA) and differential scanning calorimetry (DSC) as well as wide‐angle X‐ray diffraction (WAXD) studies. Moreover, compared with their corresponding three‐arm‐substituted counterparts T1–T4, the introduction of the ortho substituents around the truxene core in Tr1–Tr4 results in significant blueshifts (of 7–24 nm) of the absorption maxima λmax and higher energy optical gaps (Eg). Comparative studies with corresponding linear, rod‐shaped oligofluorene counterparts (OFX) have revealed that the longest para‐conjugated segment in the TrX (X=1–4) structures plays the dominant role in determining their electronic properties. UV/Vis data and cyclic voltammetry (CV) investigations have indicated that there is little electronic interaction between the arms, even for the shortest armed oligomer Tr1. A clear linear relationship of both 1/λmax and Eg with the inverse of (n+1) for these branched systems was found. Our findings highlight a novel molecular design comprising an ortho‐substituted, multiarmed architecture that would allow the introduction of isotropic physical and/or mechanical properties, while at the same time maintaining most of the important electronic properties of the rod‐shaped constituents of a fully conjugated system.
Base‐Catalyzed Stereoselective Vinylation of Ketones with Arylacetylenes: A New C(sp3)C(sp2) Bond‐Forming Reaction
Authors: Trofimov Boris A. , Schmidt Elena Yu. , Ushakov Igor' A. , Zorina Nadezhda V. , Skital'tseva Elena V. , Protsuk Nadezhda I. , Mikhaleva Al'bina I. 
Published: June 2010

AbstractAlkylaryl‐ and alkylheteroarylketones, including those with condensed aromatic moieties, are readily vinylated with arylacetylenes (KOH/DMSO, 100 °C, 1 h) to give regio‐ and stereoselectively the (E)‐β‐γ‐ethylenic ketones ((E)‐3‐buten‐1‐ones) in 61–84 % yields and with approximately 100 % stereoselectivity. This vinylation represents a new C(sp3)C(sp2) bond‐forming reaction of high synthetic potential.
ChemInform Abstract: Thermodynamic Properties of Liquid, Undercooled Liquid and Amorphous Al—Cu—La—Ni Alloys.
Authors: Zhou S. H. , Sommer F. 
Published: June 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Carbons for Lithium Battery Applications Prepared Using Sepiolite as an Inorganic Template.
Authors: Sandi G. , Carrado K. A. , Winans R. E. , Johnson C. S. , Csencsits R. 
Published: June 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: A Highly Active Solid Superacid Catalyst for n‐Butane Isomerization: Persulfate Modified Al2O3—ZrO2.
Authors: Xia Y. D. , Hua W. M. , Tang Y. , Gao Z. 
Published: June 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Stereocomplementary Construction of Optically Active Bicyclo[4.3.0]nonenone Derivatives.
Authors: Mukai Chisato , Kim Jin Sung , Sonobe Horoshi , Hanaoka Miyoji 
Published: June 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis, Equilibration, and Coupling of 4‐Lithio‐1,3‐dioxanes: Synthons for syn‐ and anti‐1,3‐Diols.
Authors: Rychnovsky Scott D. , Buckmelter Alexandre J. , Dahanukar Vilas H. , Skalitzky Donald J. 
Published: June 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: A Hard—Soft Acid—Base and DFT Analysis of Singlet—Triplet Gaps and the Addition of Singlet Carbenes to Alkenes.
Authors: Mendez Francisco , Garcia‐Garibay Miquel A. 
Published: June 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Oxidation of Methyl Groups in the Reaction of Sulfur Homopolyatomic Cations with Acetonitrile: Formation and Crystal Structure of the Novel Trithietanylium Ring.
Authors: Cameron T. Stanley , Decken Andreas , Fang Min , Parsons Simon , Passmore Jack , Wood Dale J. 
Published: June 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Palladium(II)‐Catalyzed Oxidation of Alcohols to Aldehydes and Ketones by Molecular Oxygen.
Authors: Nishimura Takahiro , Onoue Tomoaki , Ohe Kouichi , Uemura Sakae 
Published: June 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Nitration of Polycyclic Aromatic Hydrocarbons Using a Supported Catalyst.
Authors: Smith Amy C. , Narvaez Lorena D. , Akins Bridget G. , Langford Moses M. , Gary Thomas , Geisler Victoria J. , Khan Farooq A. 
Published: June 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Palladium‐Catalyzed Enantioselective Carbonylative Cyclization of Aryl and Alkenyl Triflates with Carbon Monoxide.
Authors: Hayashi Tamio , Tang Jun , Kato Kazuhiko 
Published: June 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.