bluuebunny/crossref_metadata_2025_split huggingface dataset:
Leukocytospermia does not negatively impact outcomes in in vitro fertilization cycles with intracytoplasmic sperm injection and preimplantation genetic testing for aneuploidy: findings from 5435 cycles
Authors: Gill Pavan , Puchalt Nicolas Garrido , Molinaro Thomas , Werner Marie , Seli Emre , Hotaling James , Cheng Philip 
Published: April 2024

Abstract
Purpose
To investigate whether leukocytospermia (defined as the presence of ≥ 1 × 106 white blood cells/mL) affects clinical and embryologic outcomes in in vitro fertilization (IVF) cycles with intracytoplasmic sperm injection (ICSI) and preimplantation genetic testing for aneuploidy (PGT-A).

Methods
This was a retrospective cohort study including 5425 cycles between January 2012 to December 2021 at a single large university-affiliated fertility clinic. The primary outcome was live birth rate (LBR).

Results
The prevalence of leukocytospermia was 33.9% (n = 1843). Baseline characteristics including female age, BMI, AMH, Day 3 FSH, and male partner’s age were similar in cycles with and without leukocytospermia. The LBR after the first euploid embryo transfer was similar in those with and without leukocytospermia (62.3% vs. 63% p = 0.625). Secondary outcomes including clinical pregnancy rate (CPR), sustained implantation rate (SIR), fertilization (2PN) rate, blastulation rate, and aneuploidy rate were also evaluated. The CPR (73.3% vs 74.9%, p = 0.213) and SIR (64.6% vs. 66%, p = 0.305) were similar in both groups. The 2PN rate was also similar in both groups (85.7% vs. 85.8%, p = 0.791), as was the blastulation rate per 2PN (56.7% vs. 57.5%, p = 0.116). The aneuploidy rate was not significantly different between groups (25.7% vs 24.4%, p = 0.053). A generalized estimation equation with logistic regression demonstrated that the presence leukocytospermia did not influence the LBR (adjusted OR 0.878; 95% CI, 0.680–1.138).

Conclusion
Leukocytospermia diagnosed just prior to an IVF cycle with PGT-A does not negatively impact clinical or embryologic outcomes.
Integrated approach to assessing strength in slag-based geopolymer mortars: experimental study and modeling with advanced techniques
Authors: KILIÇARSLAN Serhat , BINGOL Şinasi 
Published: April 2024

AbstractThe study consists of two main parts. In the initial phase, a variety of slag-based geopolymer mortars with different activator concentrations were prepared. These mortars underwent curing in both water and air environments for periods of 3, 7, 28, and 90 days, after which their compressive strength was evaluated at the conclusion of each curing interval. The second phase of the study is dedicated to the development of innovative models for estimating the compressive strength based on the data gathered. To achieve this, a range of techniques including multi-gene genetic programming (MGGP), artificial neural networks (ANN), XGBoost, SVM-Gauss, long short-term memory (LSTM), and convolutional neural networks (CNN) were employed to formulate a model capable of estimating compressive strength accurately. The study made use of various performance evaluation metrics such as mean squared error (MSE), root mean squared error (RMSE), R-squared, mean absolute error (MAE), and scatter index (SI) to assess the precision of the MGGP method in evaluating slag-based geopolymer mortars under both water and air curing conditions. The findings indicate that the equations generated by the MGGP method exhibit a high level of precision when juxtaposed with experimental outcomes. This research endeavors to enhance the prediction of compressive strength in geopolymer mortars, a subject that has garnered significant interest in scholarly literature.
Diet and physical activity behaviors: how are they related to illness perceptions, coping, and health-related quality of life in young people with hereditary cancer syndromes?
Authors: Rising Camella J. , Huelsnitz Chloe O. , Shepherd Rowan Forbes , Klein William M. P. , Sleight Alix G. , Wilsnack Catherine , Boyd Patrick , Feldman Alexandra E. , Khincha Payal P. , Werner-Lin Allison 
Published: April 2024

AbstractIndividuals with inherited cancer syndromes, such as Li-Fraumeni syndrome (LFS), may be motivated to adopt health-protective behaviors, such as eating more fruits and vegetables and increasing physical activity. Examining these health behaviors among young people with high lifetime genetic cancer risk may provide important insights to guide future behavioral interventions that aim to improve health-related quality of life (HRQOL). We used a self-regulatory framework to investigate relationships among diet and physical activity behaviors and psychosocial constructs (e.g., illness perceptions, coping, HRQOL) in adolescents and young adults (AYAs; aged 15–39 years) with LFS. This longitudinal mixed-methods study included 57 AYAs aged 16–39 years at enrollment), 32 (56%) of whom had a history of one or more cancers. Participants completed one or two telephone interviews and/or an online survey. We thematically analyzed interview data and conducted regression analyses to evaluate relationships among variables. AYAs described adopting healthy diet and physical activity behaviors to assert some control over health and to protect HRQOL. More frequent use of active coping strategies was associated with greater reported daily fruit and vegetable intake. Greater reported physical activity was associated with better quality of psychological health. Healthy diet and physical activity behaviors may function as LFS coping strategies that confer mental health benefits. Clinicians might emphasize these potential benefits and support AYAs in adopting health behaviors that protect multiple domains of health. Future research could use these findings to develop behavioral interventions tailored to AYAs with high genetic cancer risk.
Welfare Subjectivism, Sophistication, and Procedural Perfectionism
Authors: Ishida Shu 
Published: April 2024

AbstractWelfare subjectivists face a dilemma. On the one hand, traditional subjectivist theories—such as the desire-fulfillment theory—are too permissive to account for the well-being of typical mature human beings. On the other hand, more “refined” theories—such as the life-satisfaction theory—are too restrictive to account for the well-being of various welfare subjects, including newborns, those with profound cognitive impairments, or non-human animals. This paper examines a class of welfare subjectivism that addresses this dilemma with sensitivity to the diversity in welfare subjects. First, the most-sophisticated-attitude view (MSA) is introduced. MSA holds that an object, $$x$$
x
, is good for a subject, $$S$$
S
, in proportion to the strength of $$S$$
S
’s pro-attitude towards $$x$$
x
if and only if the pro-attitude at issue is $$S$$
S
’s most sophisticated type. Typically, the well-being of typical mature human beings is assessed in terms of one’s authentic whole-life satisfaction, whereas that of human newborns is assessed in terms of something less sophisticated such as pleasure. MSA offers the rationale for this difference based on an underexplored version of perfectionism: procedural perfectionism. Next, provided that MSA may involve an implausibly strong claim, this paper examines two moderate variations of MSA that accept the partial relevance of less sophisticated types of valenced attitude. Finally, it is illustrated how MSA and its variations have plausible implications regarding the well-being of enhanced or dis-enhanced people.
Automation of MKID Simulations for Array Building with AEM (Automated Electromagnetic MKID Simulations)
Authors: McAleer Cáthal , Creaner Oisin , Bracken Colm , Ulbricht Gerhard , De Lucia Mario , Piercy Jack , Ray Tom 
Published: April 2024

AbstractMicrowave Kinetic Inductance Detectors (MKIDs) are photon detectors comprised of superconducting LC resonators with unique resonant frequencies corresponding to their geometrical structure. As each pixel has its own geometry, electromagnetic simulations by hand of every pixel in a kilo-pixel array are impractical. Simulating fewer pixels and interpolating in between risks reduced pixel yield in arrays due to overlapping resonant frequencies. We introduce a new software called AEM (Automated Electromagnetic MKID simulations) that automates the construction and simulation of every simulated MKID pixel in an array according to specified resonant frequencies and a Qc range. We show automated designs to have an increased pixel yield (avoiding loses due to interpolation completely), increased accuracy in resonance frequency and Qc values when compared to interpolated structures. We also demonstrate a simulated trial of AEM for 100 MKIDs between 4 and 8 GHz to produce MKIDs with accuracies of ± 0.2 MHz with a runtime of 10 h 45 min.
Preformulation studies of levonorgestrel
Authors: Ridichie Amalia , Ledeţi Adriana , Sbârcea Laura , Rusu Gerlinde , Muntean Cornelia , Cîrcioban Denisa , Peter Francisc , Ledeţi Ionuţ 
Published: April 2024

AbstractLevonorgestrel, also called the morning-after pill, is a synthetic progestogen presenting structural similarities with progesterone. It is mostly used for its contraceptive effect in the form of intrauterine devices, subcutaneous implants, patches, dragées, tablets, coated tablets and orodispersible tablets being the first contraceptive that was used containing only a derivative of progestogen. Because of its wide use and various pharmaceutical formulations, it is necessary to evaluate the presence of any potential interactions between the active pharmaceutical ingredient and pharmaceutical excipients in the development of new formulations which possess increased stability and shelf life. The purpose of this study was to assess if there are any interactions between levonorgestrel and several excipients used in the pharmaceutical field, having different roles in the development of solid formulations. The studies were carried out on binary mixtures containing levonorgestrel and excipient. For the formation of the binary mixture, each excipient was used in a 1:1 mass ratio with the substance of pharmaceutical interest, levonorgestrel and the instrumental investigation results were compared to the ones of the pure active pharmaceutical ingredient and excipients. Alongside thermal analysis (TG/DTG/DSC), ATR-FTIR spectroscopy and PXRD analysis were used to evaluate the occurrence of possible interactions. For a more accurate interpretation of the obtained results, statistical calculations were performed, namely obtaining the value of the correlation coefficient. The results show the lack of a chemical interaction between levonorgestrel and microcrystalline cellulose, sodium carboxymethyl cellulose, calcium lactate pentahydrate, α-lactose monohydrate and talc. In the case of the physical mixtures which contain as excipients: aspartame and magnesium stearate a chemical interaction is observed at ambient temperature and when heated. Regarding the binary mixtures which contain mannitol, starch and colloidal silicon dioxide at ambient temperature no chemical interaction is observed, but when heated it can be noticed the existence of a chemical interaction between levonorgestrel and those excipients. As concerns the BM between LNG and PVP, precautions should be taken into consideration, due to the possibility of a chemical interaction even at ambient temperature.
Dapagliflozin promotes browning of white adipose tissue through the FGFR1-LKB1-AMPK signaling pathway
Authors: Lv Yue , Zhao Chengrui , Jiang Qiuyan , Rong Yilin , Ma Mingfeng , Liang Lili , Li Weiping , Zhang Jiuxuan , Xu Ning , Wu Huiwen 
Published: April 2024

Abstract

Background
Obesity is associated with a wide variety of metabolic disorders that impose significant burdens on patients and society. The “browning” phenomenon in white adipose tissue (WAT) has emerged as a promising therapeutic strategy to combat metabolic disturbances. However, though the anti-diabetic drug dapagliflozin (DAPA) is thought to promote “browning,” the specific mechanism of this was previously unclear.

Methods
In this study, C57BL/6 J male mice were used to establish an obesity model by high-fat diet feeding, and 3T3-L1 cells were used to induce mature adipocytes and to explore the role and mechanism of DAPA in “browning” through a combination of in vitro and in vivo experiments.

Results
The results show that DAPA promotes WAT "browning" and improves metabolic disorders. Furthermore, we discovered that DAPA activated "browning" through the fibroblast growth factor receptors 1-liver kinase B1-adenosine monophosphate-activated protein kinase signaling pathway.

Conclusion
These findings provide a rational basis for the use of DAPA in treating obesity by promoting the browning of white adipose tissue.
A rare KMT2A::CBL transcript in an acute monoblastic leukemia patient with an unfavorable outcome
Authors: Yu Jinglei , Song Fengmei , Zhang Mingming , Xiao Pingnan , Feng Jingjing , Hong Ruimin , Hu Yongxian , Huang He , Wei Guoqing 
Published: April 2024

Abstract

Background
Lysine [K] methyltransferase 2A (KMT2A, previously known as MLL) gene rearrangements are common in acute leukemias of various lineages and are associated with features such as chemotherapy resistance and rapid relapse. KMT2A::CBL is a rare fusion of unknown pathogenesis generated by a unique interstitial deletion of chromosome 11 that has been reported across a wide age range in both acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL) patients. The leukemogenic effect of the KMT2A::CBL rearrangement and its association with clinical prognosis have not been well clarified.

Methods and results
We report the case of a 64-year-old female who was diagnosed with acute monoblastic leukemia (M5a) and who acquired the rare KMT2A::CBL fusion. The patient received multiple cycles of therapy but did not achieve remission and eventually succumbed to severe infection and disease progression. Additionally, we characterized the predicted KMT2A-CBL protein structure in this case to reveal the underlying leukemogenic mechanisms and summarized reported cases of hematological malignancies with KMT2A::CBL fusion to investigate the correlation of gene rearrangements with clinical outcomes.

Conclusions
This report provides novel insights into the leukemogenic potential of the KMT2A::CBL rearrangement and the correlation between gene rearrangements and clinical outcomes.
Psychosocial Factors Associated with Cognitive Function in Prostate Cancer Survivors on Hormonal Treatments: A Systematic Review
Authors: Pembroke Lorna , Sherman Kerry A. , Francis Heather , Dhillon Haryana M. , Gurney Howard , Gillatt David 
Published: April 2024

AbstractHormonal treatments (HT) for prostate cancer (e.g., androgen deprivation therapy) yield clinical and survival benefits, yet adverse cognitive changes may be a side effect. Since psychosocial factors are largely modifiable, interventions targeting these factors may help mitigate these adverse cognitive effects. This systematic review aimed to identify a range of psychosocial factors associated with cognitive function in individuals with prostate cancer undergoing HT and to determine whether these factors mitigate or exacerbate this effect. Applying PRISMA guidelines, a comprehensive search of relevant databases conducted in September 2023 using terms related to prostate cancer, hormone therapy, and cognitive outcomes was undertaken. The search yielded 694 unique abstracts, with 11 studies included for analysis examining the relationship between cognitive function and the following psychosocial factors: psychological distress, fatigue, insomnia, and coping processes. Findings were mixed with only two studies reporting significant associations between cognitive performance with fatigue and depression. Three studies that included measures of perceived cognitive function identified associations with depression, anxiety, fatigue, insomnia, illness threat appraisals, and coping styles. However, no studies found evidence for an association between self-reported and objective measures of cognitive functioning. Evidence regarding the association of interpersonal factors is lacking. Moreover, whether these factors mitigate or exacerbate the effect of HT on cognitive function still needs to be determined. Overall, the research exploring the association between psychosocial factors and cognitive function in prostate cancer survivors undergoing HT is still in its infancy. Further research is required to optimize the implementation of neuropsychological interventions for prostate cancer survivors.
Quantifying effects of changes in forest age distribution on the landslide frequency in Japan
Authors: Lusiana Novia , Shinohara Yoshinori , Imaizumi Fumitoshi 
Published: April 2024

AbstractLandslides are destructive natural disasters that cause human and economic losses. Although many studies report the effects of forest age on landslide susceptibility, especially for shallow landslides, no studies have examined the effects at a national scale. We assumed that temporal variations in the annual number of rainfall-triggered landslides in Japan were determined by variations in rainfall and forest age distribution. By this assumption, this study aimed to quantify the decrease in the frequency of rainfall-induced landslides owing to the increasing maturity of forests in Japan. Data were collated from 21 studies covering 11 sites in three countries that reported a landslide susceptibility index (i.e., frequency ratio or landslide density) and the relation between forest age and the normalized landslide susceptibility index (NLSI) was modeled. Using this relation and the area for each forest age class, the change in landslide susceptibility at a national scale (NLSIJpn) was quantified during 1966–2017. The authors developed generalized linear models (GLMs) using the annual number of landslides as the response variable and the NLSIJpn and a rainfall index for each year as the explanatory variables. The number of rainfall-induced landslides was simulated in the GLMs in 15 scenarios with different forest age distributions and rainfall amounts. The number of landslides in young-age-dominated and middle-age-dominated forests was estimated to be 2.4 and 1.1 times, respectively, that in mature-age-dominated forests. The change in the number of landslides from young-age-dominated to mature-age-dominated forests was larger than that from an increase in the rainfall amount of 20%. We conclude that increasing the maturity of forests greatly reduces landslide frequency in Japan. In a changing climate with potentially threatening increases in rainfall, preserving mature forests is important to avoid amplifying landslide susceptibility on a national scale.
Intergovernmental alignment and the electoral value of mayors: reverse coattails in an unexpected technocracy
Authors: Savu Alexandru 
Published: April 2024

AbstractAlthough parties are documented to invest significant amounts of resources towards strengthening their hold on local governments, whether mayors benefit their parties in national elections remains an open question. More specifically, it is unclear if mayors are electorally valuable in periods when party-affiliated central governments do not support them via politically discriminatory policies. We address this gap by studying “reverse coattails” in a unique setting: under a technocratic central government instituted following an unexpected, exogenous tragic event that forced the previous government’s resignation. Investigating close mayoral races in Romania in a regression discontinuity analysis, we find that local incumbency generated meaningful vote share premiums in the 2016 parliamentary elections. Exploring the underlying mechanism, we retrieve evidence for prospective voting, suggesting that the reverse coattails we document are partially driven by voters’ expectations of future preferential resource allocations by the central government. We show that preferential central policies were implemented after, but not before the national elections, and find that reverse coattails were stronger in constituencies where funds received from the center are an important component of local revenues.
FODMAP Content Like-by-like Comparison in Spanish Gluten-free and Gluten-containing Cereal-based Products
Authors: Matias Silvia , Perez-Junkera Gesala , Martínez Olaia , Miranda Jonatan , Larretxi Idoia , Peña Lidia , Bustamante María Ángeles , Churruca Itziar , Simón Edurne 
Published: April 2024

AbstractGluten-free foods (GF) availability on supermarket shelves is growing and it is expected to continue expanding in the years ahead. These foods have been linked to a lower content of fermentable oligosaccharides, disaccharides, monosaccharides and polyols (FODMAPs), molecules that trigger gastrointestinal symptoms in sensitive persons. In this study, the FODMAP content of 25 cereal-based GF foods in Spain (breakfast cereals, pasta, bread, biscuits, bakery products, and dough and puff pastry) and 25 gluten-containing equivalents (GC) available in the same supermarket were analysed and compared. Lactose, fructose, glucose, sorbitol, mannitol, raffinose, stachyose and fructans were quantified. In a like-by-like analysis, GF foods were found to generally contain fewer FODMAPs than their GC counterparts. The ingredients used in the manufacture of GF cereal-based foods may contribute to this fact. When the individually wrapped size was considered, the proportion of samples classified as high-FODMAPs in GC and GF foods showed a trend towards fewer samples in the GF. However, not all the GF samples were low-FODMAP. Altogether, our findings provide essential information for FODMAP content databases of GF products in Spain.
Tackling Cyclicity in Causal Models with Cross-Sectional Data Using a Partial Least Squares Approach: Implications for the Sequential Model of Internet Appropriation
Authors: Lamberti Giuseppe , Lopez-Sintas Jordi , Pandolfo Giuseppe 
Published: April 2024

AbstractWorking with SEM and cross-sectional data, and depending on the studied phenomenon, assuming an acyclic model may mean that we obtain only a partial view of the mechanisms that explain causal relationships between a set of theoretical constructs, given that variables are treated as antecedents and consequences. Our two-step approach allows researchers to identify and measure cyclic effects when working with cross-sectional data and a PLS modelling algorithm. Using the resources and appropriation theory and the sequential model of internet appropriation, we demonstrate the importance of considering cyclic effects. Our results show that opportunities for physical access followed by digital skills acquisition enhance internet usage (acyclic effects), but also that internet usage intensity, in reverse, reinforces both digital skills and physical access (cyclic effects), supporting Norris (Digital divide: civic engagement, information poverty, and the internet worldwide. Cambridge University Press, Cambridge, 2001) social stratification hypothesis regarding future evolution of the digital divide.