bluuebunny/crossref_metadata_2025_split huggingface dataset:
Caminhos de penetração da capitania de São Paulo
Authors: Reis Paulo Pereira dos 
Published: May 2024

The São Paulo Village played a very important part as a irradiative center to the penetration and conquer of the Brazilian backwoods. It happened mainly because of its expedition in the direction of the west and Southern that were besides the “Tordesilhas” meridian. This historical dones were favored by São Paulo geographical situation, which was the first nucleus of the Portuguese settling, raised in the inland of Brazil. This became the man of São Paulo by his habitat the “bandeirante” beyond comparison. The conquer of the backwoods were in his historical destiny.There was nearly São Paulo the springs of the rivers “Paraíba do Sul” and “Tietê” that permitted to the “bandeirantes” the penetration down the river in the East—North and western directions. The Tietê river, admirable road, which propitiated the contacts with the Paraná River and the affluents of the Paraguai River, becomes detached in the exceptional geographical position of São Paulo Village. The expeditions for the capture of the indian slaves and to look for metais and precious stones led the men of São Paulo to another ways in the backwoods which diffused from São Paulo to all the directions of the country. So São Paulo performed his historical destiny populating and enlarging considerably the Brazilian territory.
A new species of freshwater crab, Demanietta moror, from a karst formation in southern Thailand (Brachyura, Potamidae)
Authors: Tan Zhi Wan , Lheknim Vachira , Ng Peter K. L. 
Published: May 2024

Abstract
A new species of potamid crab belonging to the genus Demanietta Bott, 1966 is described from a creek draining out of a karst formation associated with the Phuket Mountain Range in southern Thailand. Demanietta moror new species, belongs to a group of Demanietta species that has a relatively inflated and smooth carapace, and a male first gonopod that is weakly bent, appearing more vertically projected. It can be immediately distinguished from all congeners by its carapace, gonopod morphology and unique colour pattern in life.
A new species of freshwater crab, Sundathelphusa roberti (Brachyura, Gecarcinucidae) from highlands in Batangas, Luzon, Philippines
Authors: Ng Peter K. L. , Mendoza Jose C. E. 
Published: May 2024

Abstract
A new species of freshwater crab belonging to a group of species morphologically similar to Sundathelphusa philippina (Von Martens, 1868) is described from highlands in the province of Batangas, southern Luzon, Philippines. Sundathelphusa roberti new species, however, differs from members of this group by the position and strength of the epigastric and postorbital cristae, form of the posterior epistomal margin, shape of the third maxillipeds, and structure of the male first gonopod. The new taxon is the 35th species of Sundathelphusa known from the Philippines.
Inconsistent effects of environmental variations on body size and density of pillbugs, Armadillidium vulgare (Latreille, 1804) (Isopoda, Oniscidea) in urban green spaces
Authors: Yang Li , Zhu Zhangyan , Wang Shuang , Li Hongshan , Ge Baoming 
Published: May 2024

Abstract
Urban green spaces offer opportunity to detect the response of species to environmental variations by exploring population density and body size variations. In May 2022, we collected pillbugs from five urban green spaces in Yancheng, Jiangsu, P.R. China. One-way ANOVA, principal component analysis, Cramer’s V. Mantel test and regression analysis were employed in this study. We found that the body size varied significantly among different urban spaces, while density did not. Most of the environmental properties were significantly different, except electrical conductivity and total nitrogen. The number of plant species and pH were distinguished as the main factors shaping the habitats. Body size related to the food resources, and density related to pH and vegetation coverage. Then body length and weight presented a significant positive correlation. A clumped distribution pattern of pillbugs was detected by Taylor’s and Iwao’s regressions. The environmental variations presented inconsistent effects on density and body size.
First occurrence of the family Botryllophilidae Sars G.O., 1921 (Copepoda, Cyclopoida) in Sicily, central Mediterranean Sea
Authors: Lo Brutto S. , Badalucco A. , Musco L. 
Published: May 2024

Abstract
A female copepod specimen belonging to the family Botryllophilidae Sars G.O., 1921 was retrieved for the first time in December 2023 from nautical ropes of the tourist marina in Palermo (Cala Marina), near the commercial port of the city. The individual lacks many of the distinctive morpho-anatomical characteristics of the class Copepoda, as usual in cyclopoid parasites. In this group, females typically carry paired multiseriate egg sacs, which are extruded from the genital openings and lead to taxonomic identification. The family is commonly associated with tunicates. There are few reports of commensal and/or parasitic copepods associated with sea squirts in the Mediterranean Sea. This record cannot be treated as a new non-indigenous species for the Italian coasts yet, as there are no extensive studies on the distribution of the taxon.
Association between mechanical power during one-lung ventilation and pulmonary complications after thoracoscopic lung resection surgery: a prospective observational study
Authors: Liu Hong-Mei , Zhang Gong-Wei , Yu Hong , Li Xue-Fei , Yu Hai 
Published: May 2024

Abstract
Background
The role of mechanical power on pulmonary outcomes after thoracic surgery with one-lung ventilation was unclear. We investigated the association between mechanical power and postoperative pulmonary complications in patients undergoing thoracoscopic lung resection surgery.

Methods
In this single-center, prospective observational study, 622 patients scheduled for thoracoscopic lung resection surgery were included. Volume control mode with lung protective ventilation strategies were implemented in all participants. The primary endpoint was a composite of postoperative pulmonary complications during hospital stay. Multivariable logistic regression models were used to evaluate the association between mechanical power and outcomes.

Results
The incidence of pulmonary complications after surgery during hospital stay was 24.6% (150 of 609 patients). The multivariable analysis showed that there was no link between mechanical power and postoperative pulmonary complications.

Conclusions
In patients undergoing thoracoscopic lung resection with standardized lung-protective ventilation, no association was found between mechanical power and postoperative pulmonary complications.

Trial registration
Trial registration number: ChiCTR2200058528, date of registration: April 10, 2022.
Associations between OGTT results during pregnancy and offspring TSH levels: a birth cohort study
Authors: Yang Meng , Cao Zhongqiang , Zhu Wanting , Feng Xiaoyuan , Zhou Jieqiong , Liu Jiuying , Zhong Yuanyuan , Zhou Yan , Mei Hong , Cai Xiaonan , Hu Liqin , Zhou Aifen , Xiao Han 
Published: May 2024

Abstract
Background
Limited evidence exists regarding the association between gestational diabetes mellitus (GDM) and elevated levels of thyroid-stimulating hormone (TSH) in newborns. Therefore, this study aimed to investigate the potential risk of elevated TSH levels in infants exposed to maternal GDM, considering the type and number of abnormal values obtained from the 75-gram oral glucose tolerance test (OGTT).

Methods
A population-based, prospective birth cohort study was conducted in Wuhan, China. The study included women who underwent GDM screening using a 75-g OGTT. Neonatal TSH levels were measured via a time-resolved immunofluorescence assay. We estimated and stratified the overall risk (adjusted Risk Ratio [RR]) of elevated TSH levels (defined as TSH > 10 mIU/L or > 20 mIU/L) in offspring based on the type and number of abnormal OGTT values.

Results
Out of 15,236 eligible mother-offspring pairs, 11.5% (1,753) of mothers were diagnosed with GDM. Offspring born to women diagnosed with GDM demonstrated a statistically significant elevation in TSH levels when compared to offspring of non-GDM mothers, with a mean difference of 0.20 [95% CI: 0.04–0.36]. The incidence of elevated TSH levels (TSH > 10 mIU/L) in offspring of non-GDM women was 6.3 per 1,000 live births. Newborns exposed to mothers with three abnormal OGTT values displayed an almost five-fold increased risk of elevated TSH levels (adjusted RR 4.77 [95% CI 1.64–13.96]). Maternal fasting blood glucose was independently and positively correlated with neonatal TSH levels and elevated TSH status (TSH > 20 mIU/L).

Conclusions
For newborns of women with GDM, personalized risk assessment for elevated TSH levels can be predicated on the type and number of abnormal OGTT values. Furthermore, fasting blood glucose emerges as a critical predictive marker for elevated neonatal TSH status.
Deep learning for determining the difficulty of endodontic treatment: a pilot study
Authors: Karkehabadi Hamed , Khoshbin Elham , Ghasemi Nikoo , Mahavi Amal , Mohammad-Rahimi Hossein , Sadr Soroush 
Published: May 2024

Abstract
Background
To develop and validate a deep learning model for automated assessment of endodontic case difficulty from periapical radiographs.

Methods
A dataset of 1,386 periapical radiographs was compiled from two clinical sites. Two dentists and two endodontists annotated the radiographs for difficulty using the “simple assessment” criteria from the American Association of Endodontists’ case difficulty assessment form in the Endocase application. A classification task labeled cases as “easy” or “hard”, while regression predicted overall difficulty scores. Convolutional neural networks (i.e. VGG16, ResNet18, ResNet50, ResNext50, and Inception v2) were used, with a baseline model trained via transfer learning from ImageNet weights. Other models was pre-trained using self-supervised contrastive learning (i.e. BYOL, SimCLR, MoCo, and DINO) on 20,295 unlabeled dental radiographs to learn representation without manual labels. Both models were evaluated using 10-fold cross-validation, with performance compared to seven human examiners (three general dentists and four endodontists) on a hold-out test set.

Results
The baseline VGG16 model attained 87.62% accuracy in classifying difficulty. Self-supervised pretraining did not improve performance. Regression predicted scores with ± 3.21 score error. All models outperformed human raters, with poor inter-examiner reliability.

Conclusion
This pilot study demonstrated the feasibility of automated endodontic difficulty assessment via deep learning models.
Integrated analysis reveals critical cisplatin-resistance regulators E2F7 contributed to tumor progression and metastasis in lung adenocarcinoma
Authors: Mao Xiaomin , Xu Shumin , Wang Huan , Xiao Peng , Li Shumin , Wu Jiaji , Sun Junhui , Jin Cheng , Shen Mo , Shi Yueli , Tang Bufu , Yang Ying , Chen Weiyu , Xu Zhiyong , Xu Yun 
Published: May 2024

Abstract
Background
Drug resistance poses a significant challenge in cancer treatment, particularly as a leading cause of therapy failure. Cisplatin, the primary drug for lung adenocarcinoma (LUAD) chemotherapy, shows effective treatment outcomes. However, the development of resistance against cisplatin is a major obstacle. Therefore, identifying genes resistant to cisplatin and adopting personalized treatment could significantly improve patient outcomes.

Methods
By examining transcriptome data of cisplatin-resistant LUAD cells from the GEO database, 181 genes associated with cisplatin resistance were identified. Using univariate regression analysis, random forest and multivariate regression analyses, two prognostic genes, E2F7 and FAM83A, were identified. This study developed a prognostic model utilizing E2F7 and FAM83A as key indicators. The Cell Counting Kit 8 assay, Transwell assay, and flow cytometry were used to detect the effects of E2F7 on the proliferation, migration, invasiveness and apoptosis of A549/PC9 cells. Western blotting was used to determine the effect of E2F7 on AKT/mTOR signaling pathway.

Results
This study has pinpointed two crucial genes associated with cisplatin resistance, E2F7 and FAM83A, and developed a comprehensive model to assist in the diagnosis, prognosis, and evaluation of relapse risk in LUAD. Analysis revealed that patients at higher risk, according to these genetic markers, had elevated levels of immune checkpoints (PD-L1 and PD-L2). The prognostic and diagnosis values of E2F7 and FAM83A were further confirmed in clinical data. Furthermore, inhibiting E2F7 in lung cancer cells markedly reduced their proliferation, migration, invasion, and increased apoptosis. In vivo experiments corroborated these findings, showing reduced tumor growth and lung metastasis upon E2F7 suppression in lung cancer models.

Conclusion
Our study affirms the prognostic value of a model based on two DEGs, offering a reliable method for predicting the success of tumor immunotherapy in patients with LUAD. The diagnostic and predictive model based on these genes demonstrates excellent performance. In vitro, reducing E2F7 levels shows antitumor effects by blocking LUAD growth and progression. Further investigation into the molecular mechanisms has highlighted E2F7’s effect on the AKT/mTOR signaling pathway, underscoring its therapeutic potential. In the era of personalized medicine, this DEG-based model promises to guide clinical practice.
Correlation of FMR4 expression levels to ovarian reserve markers in FMR1 premutation carriers
Authors: Agusti Ines , Alvarez-Mora Maria Isabel , Wijngaard Robin , Borras Aina , Barcos Tamara , Peralta Sara , Guimera Marta , Goday Anna , Manau Dolors , Rodriguez-Revenga Laia 
Published: May 2024

Abstract
Background
Fragile X-associated primary ovarian insufficiency (FXPOI), characterized by amenorrhea before age 40 years, occurs in 20% of female FMR1 premutation carriers. Presently, there are no molecular or biomarkers that can help predicting which FMR1 premutation women will develop FXPOI. We previously demonstrated that high FMR4 levels can discriminate between FMR1 premutation carriers with and without FXPOI. In the present study the relationship between the expression levels of FMR4 and the ovarian reserve markers was assessed in female FMR1 premutation carriers under age of 35 years.

Methods
We examined the association between FMR4 transcript levels and the measures of total antral follicle count (AFC) and serum anti-müllerian hormone (AMH) levels as markers of ovarian follicle reserve.

Results
Results revealed a negative association between FMR4 levels and AMH (r = 0.45) and AFC (r = 0.64). Statistically significant higher FMR4 transcript levels were found among those FMR1 premutation women with both, low AFCs and AMH levels.

Conclusions
These findings reinforce previous studies supporting the association between high levels of FMR4 and the risk of developing FXPOI in FMR1 premutation carriers.
A treadmill running research protocol to assess dynamic visual acuity and balance for athletes with and without recent concussion history
Authors: Mitchell Katelyn M. , Dalton Kristine N. , Cinelli Michael E. 
Published: May 2024

AbstractAthletes interpret dynamic visual scenes quickly and accurately during physical exertion. It is important to understand how increased exertion may impact vision and cognition following sport-related concussion (SRC).Purpose To examine the effect of a treadmill running research protocol on the assessment of dynamic visual acuity (DVA) and balance for athletes with and without recent history of SRC.Methods Varsity athletes following recent SRC (CONC=12) were compared to athletes without SRC (ATHLETE=19). The DVA task presented a Tumbling ‘E’ target in four possible orientations during random walk (RW) or horizontal (H) motion at a speed of 30°/s. Participants performed DVA trials standing on a force plate (1000Hz) at four time points: 1) pre-exercise (PRE-EX), 2) immediately (POST1), 3) 10-minutes (POST10), and 4) 20-minutes post- exercise (POST20). Performance was calculated as a change in DVA score from PRE-EX and median response time (RT, ms). Balance control was analyzed using the root mean square of centre of pressure displacement (dCOP).Results Both groups maintained DVA scores for both motion types and exhibited immediate exercise-induced benefits on RT. Both groups had similar change in balance control strategy following treadmill exercise.Conclusion Both groups elicited similar exercise-induced benefits on DVA following exercise. A repeated measures assessment following vigorous exercise may provide meaningful insights about visual and neurocognitive functions for athletes returning to sport following concussion.
Large congenital cervical mass in a neonate: prenatal diagnosis and postnatal management of teratoma: a case report
Authors: Ziyaee Fateme , Forooghi Mehdi , Geramizadeh Bita , Fatemian Hossein , Ghasemian Mehdi 
Published: May 2024

Abstract
Introduction
Cervical teratomas are rare congenital neoplasms that can cause neonatal airway obstruction if large.

Case presentation
The female Persian neonate displayed respiratory distress at birth, with a 7 cm × 8 cm cystic solid mass identified on the left side of the neck. Antenatal ultrasonography revealed polyhydramnios. Despite initial stabilization, the infant required intubation and mechanical ventilation due to persistent respiratory distress. Imaging confirmed a cystic mass compressing the trachea, ruling out cystic hygroma. Surgical resection on postnatal day 17 revealed a 10 cm × 10 cm solid cystic structure, histologically identified as an immature teratoma.

Conclusion
Despite risks of poor fetal and postnatal outcome from large cervical teratomas, early surgical resection after airway stabilization can result in recovery. Proper multidisciplinary management of respiratory distress from such tumors is paramount.
On qualitative analysis of a fractional hybrid Langevin differential equation with novel boundary conditions
Authors: Ali Gohar , Khan Rahman Ullah , Kamran  , Aloqaily Ahmad , Mlaiki Nabil 
Published: May 2024

AbstractA hybrid system interacts with the discrete and continuous dynamics of a physical dynamical system. The notion of a hybrid system gives embedded control systems a great advantage. The Langevin differential equation can accurately depict many physical phenomena and help researchers effectively represent anomalous diffusion. This paper considers a fractional hybrid Langevin differential equation, including the ψ-Caputo fractional operator. Furthermore, some novel boundaries selected are considered to be a problem. We used the Schauder and Banach fixed-point theorems to prove the existence and uniqueness of solutions to the considered problem. Additionally, the Ulam-Hyer stability is evaluated. Finally, we present a representative example to verify the theoretical outcomes of our findings.
Comparison of preoperative NT-proBNP and simple cardiac risk scores for predicting postoperative morbidity after non-cardiac surgery with intermediate or high surgical risk
Authors: Schmidt Götz , Frieling Nora , Schneck Emmanuel , Habicher Marit , Koch Christian , Aßmus Birgit , Sander Michael 
Published: May 2024

Abstract
Background
Chronic heart failure (HF) is frequent in elderly patients undergoing non-cardiac surgery. Preoperative risk stratification is vital and can be achieved using simple clinical risk scores or preoperative N-terminal prohormone of brain natriuretic peptide (NT-proBNP) measurement. This study aimed to compare the predictivity of the revised cardiac risk index (RCRI), the American University of Beirut cardiovascular risk index (AUB-HAS2), and a score proposed by Andersson et al. for postoperative 30-day morbidity to preoperative NT-proBNP.

Methods
Preoperative NT-proBNP was measured in 199 consecutive patients aged ≥ 65 years undergoing elective non-cardiac surgery with intermediate or high surgical risk. The areas under the receiver operating characteristic curve (AUCROC) for the composite morbidity endpoint (CME) comprising the incidence of any rehospitalisation, acute decompensated HF, acute kidney injury, and any infection at postoperative day 30 were assessed. Multivariable logistic regression analysis derived new scores from the simple risk scores and the NT-proBNP cut-off of 450 pg/mL.

Results
AUB-HAS2, but not RCRI or Andersson score, significantly predicted the CME (AUB-HAS2: AUCROC 0.646, p < 0.001; RCRI: AUCROC 0.560, p = 0.126; Andersson: AUCROC 0.487, p = 0.760). The AUCROC was comparable between preoperative NT-proBNP (0.679, p < 0.001) and AUB-HAS2 (p = 0.334). Multivariable analyses revealed a preoperative NT-proBNP ≥ 450 pg/mL to be the strongest predictor of CME among the individual score components (p < 0.001). Adding preoperative NT-proBNP improved the predictive value of AUB-HAS2 and RCRI (modified AUB-HAS2: AUCROC 0.703, p < 0.001; modified RCRI: AUCROC 0.679, p < 0.001; both p < 0.001 vs original scores). The predictive value of the modified RCRI and AUB-HAS2 was comparable to preoperative NT-proBNP alone (p = 0.988 vs modified RCRI, p = 0.367 vs modified AUB-HAS2).

Conclusions
The predictive value of postoperative morbidity varies significantly between the available simple perioperative risk scores and can be enhanced by preoperative NT-proBNP. New scores, including preoperative NT-proBNP, should be evaluated in large multicentre cohorts.

Trial registration
German Clinical Trials Register: DRKS00027871.
Meta-analysis of genomic variants in power and endurance sports to decode the impact of genomics on athletic performance and success
Authors: Psatha Aikaterini , Al-Mahayri Zeina N. , Mitropoulou Christina , Patrinos George P. 
Published: May 2024

AbstractAssociation between genomic variants and athletic performance has seen a high degree of controversy, as there is often conflicting data as far as the association of genomic variants with endurance, speed and strength is concerned. Here, findings from a thorough meta-analysis from 4228 articles exploring the association of genomic variants with athletic performance in power and endurance sports are summarized, aiming to confirm or overrule the association of genetic variants with athletic performance of all types. From the 4228 articles, only 107 were eligible for further analysis, including 37 different genes. From these, there were 21 articles for the ACE gene, 29 articles for the ACTN3 gene and 8 articles for both the ACE and ACTN3 genes, including 54,382 subjects in total, from which 11,501 were endurance and power athletes and 42,881 control subjects. These data show that there is no statistically significant association between genomic variants and athletic performance either for endurance or power sports, underlying the fact that it is highly risky and even unethical to make such genetic testing services for athletic performance available to the general public. Overall, a strict regulatory monitoring should be exercised by health and other legislative authorities to protect the public from such services from an emerging discipline that still lacks the necessary scientific evidence and subsequent regulatory approval.