bluuebunny/crossref_metadata_2025_split huggingface dataset:
On the value of hydrochemical data for the interpretation of flow and transport processes in the Baget karst system, France
Authors: Richieri Beatrice , Bittner Daniel , Sivelle Vianney , Hartmann Andreas , Labat David , Chiogna Gabriele 
Published: June 2024

AbstractContinuous hourly time series of hydrochemical data can provide insights into the subsurface dynamics and main hydrological processes of karst systems. This study investigates how high-resolution hydrochemical data can be used for the verification of robust conceptual event-based karst models. To match the high temporal variability of hydrochemical data, the LuKARS 2.0 model was developed on an hourly scale. The model concept considers the interaction between the matrix and conduit components to allow a flexible conceptualization of binary karst systems characterized by a perennial spring and intermittent overflow as well as possible surface water bypassing the spring. The model was tested on the Baget karst system, France, featuring a recharge area defined by the coexistence of karst and nonkarst areas. The Morris screening method was used to investigate parameter sensitivity, and to calibrate the model according to the Kling-Gupta Efficiency (KGE). Model verification was performed by considering additional hydrochemical constraints with the aim of representing the internal dynamics of the systems, i.e., water contributions from the various compartments of the conceptual model. The hydrochemical constraints were defined based on high-temporal resolution time series of SO42− and HCO3−. The results of this study show that the simulation with the highest KGE among 9,000 model realizations well represents the dynamics of the spring discharge but not the variability of the internal fluxes. The implementation of hydrochemical constraints facilitates the identification of realizations reproducing the observed relative increase in the flow contribution from the nonkarst area.
Spontaneous intracerebral hemorrhage – patients retrospectively consent to fibrinolytic surgery despite poor neurological outcome and reduced health-related quality of life
Authors: Schwiddessen Regina , Malinova Vesna , von Steinbüchel Nicole , Mielke Dorothee , Rohde Veit , von der Brelie Christian 
Published: June 2024

AbstractSpontaneous intracerebral hemorrhage (ICH) might lead to devastating consequences. Nonetheless, subjective interpretation of life circumstances might vary. Recent data from ischemic stroke patients show that there might be a paradox between clinically rated neurological outcome and self-reported satisfaction with quality of life. Our hypothesis was that minimally invasive surgically treated ICH patients would still give their consent to stereotactic fibrinolysis despite experiencing relatively poor neurological outcome. In order to better understand the patients’ perspective and to enhance insight beyond functional outcome, this is the first study assessing disease-specific health-related quality of life (hrQoL) in ICH after fibrinolytic therapy. We conducted a retrospective analysis of patients with spontaneous ICH treated minimally invasive by stereotactic fibrinolysis. Subsequently, using standardized telephone interviews, we evaluated functional outcome with the modified Rankin Scale (mRS), health-related Quality of Life with the Quality of life after Brain Injury Overall scale (QOLIBRI-OS), and assessed retrospectively if the patients would have given their consent to the treatment. To verify the primary hypothesis that fibrinolytic treated ICH patients would still retrospectively consent to fibrinolytic therapy despite a relatively poor neurological outcome, we conducted a chi-square test to compare good versus poor outcome (mRS) between consenters and non-consenters. To investigate the association between hrQoL (QOLIBRI-OS) and consent, we conducted a Mann-Whitney U-test. Moreover, we did a Spearman correlation to investigate the correlation between functional outcome (mRS) and hrQoL (QOLIBRI-OS). The analysis comprised 63 data sets (35 men, mean age: 66.9 ± 11.8 years, median Hemphill score: 3 [2-3]). Good neurological outcome (mRS 0–3) was achieved in 52% (33/63) of the patients. Patients would have given their consent to surgery retrospectively in 89.7% (52/58). These 52 consenting patients comprised all 33 patients (100%) who achieved good functional outcome and 19 of the 25 patients (76%) who achieved poor neurological outcome (mRS 4–6). The mean QOLIBRI-OS value was 49.55 ± 27.75. A significant association between hrQoL and retrospective consent was found (p = 0.004). This study supports fibrinolytic treatment of ICH even in cases when poor neurological outcome would have to be assumed since subjective perception of deficits could be in contrast with the objectively measured neurological outcome. HrQoL serves as a criterion for success of rtPa lysis therapy in ICH.
Stoma associated complications after diverting loop ileostomy, end ileostomy or split stoma formation after right sided colectomy—a retrospective cohort study (StoComSplit Analysis)
Authors: Wiesler B. , Hirt L. , Guenin M.-O. , Steinemann D. C. , von Flüe M. , Müller-Stich B. , Glass T. , von Strauss und Torney M. 
Published: June 2024

Abstract
Background
For high-risk patients receiving right-sided colectomy, stoma formation is a safety strategy. Options are anastomosis with loop ileostomy, end ileostomy, or split stoma. The aim is to compare the outcome of these three options.

Methods
This retrospective cohort study included all patients who underwent right sided colectomy and stoma formation between January 2008 and December 2021 at two tertial referral centers in Switzerland. The primary outcome was the stoma associated complication rate within one year.

Results
A total of 116 patients were included. A total of 20 patients (17%) underwent primary anastomosis with loop ileostomy (PA group), 29 (25%) received an end ileostomy (ES group) and 67 (58%) received a split stoma (SS group).
Stoma associated complication rate was 43% (n = 21) in PA and in ES group and 50% (n = 34) in SS group (n.s.). A total of 30% (n = 6) of patients in PA group needed reoperations, whereas 59% (n = 17) in ES and 58% (n = 39) in SS group had reoperations (P = 0.07). Wound infections occurred in 15% (n = 3) in PA, in 10% (n = 3) in ES, and in 30% (n = 20) in SS group (P = 0.08). A total of 13 patients (65%) in PA, 7 (24%) in ES, and 29 (43%) in SS group achieved stoma closure (P = 0.02). A total of 5 patients (38%) in PA group, 2 (15%) in ES, and 22 patients (67%) in SS group had a stoma-associated rehospitalization (P < 0.01).

Conclusion
Primary anastomosis and loop ileostomy may be an option for selected patients. Patients with end ileostomies have fewer stoma-related readmissions than those with a split stoma, but they have a lower rate of stoma closure.

Clinical trial registration
Trial not registered.
Statin use is associated with a lower risk of all-cause death in patients with breast cancer treated with anthracycline containing regimens: a global federated health database analysis
Authors: Bucci Tommaso , Gue Ying , Dobson Rebecca , Palmieri Carlo , Pignatelli Pasquale , Lip Gregory Y. H. 
Published: June 2024

AbstractAnthracyclines are associated with enhanced oxidative stress responsible for adverse events in patients with breast cancer. However, no study has investigated the potential anti-inflammatory role of statins in counteracting anthracycline toxicity. In this retrospective study utilizing a federated health network (TriNetX), patients with breast cancer (ICD code C50) treated with anthracyclines were categorized into two groups: statin users (for at least 6 months); and statin non-users. The primary outcome was the 5-year risk of all-cause death. Secondary outcomes were the risk of myocardial infarction, stroke, atrial fibrillation, ventricular arrhythmias, heart failure, and pulmonary embolism. Cox-regression analyses were used to produce hazard ratios (HRs) and 95% confidence intervals (CI) following 1:1 propensity score matching (PSM). We identified 3,701 statin users (68.8 ± 10.4 years) and 37,185 statin non-users (59.6 ± 12.8 years). After PSM, the 5-year risk of all-cause death was significantly lower in statin users (HR 0.82, 95% CI 0.74–0.91) compared to statins non-users. Analyzing the risk for secondary outcomes, only the risk of stroke was significantly increased in statin users (HR 1.27, 95% CI 1.01–1.61), while no associations were found for the other cardiovascular events. The risk of all-cause death in statin users was the lowest during the first year after the anthracycline’s initiation. No significant difference was found between lipophilic and hydrophilic statins. In patients with breast cancer treated with anthracyclines, statin use is associated with a reduced risk of all-cause death. Prospective studies are needed to investigate the potential beneficial effect of statin initiation in cancer patients without other indications.
The allocation of FIFA World Cup slots based on the ranking of confederations
Authors: Csató László , Kiss László Marcell , Szádoczki Zsombor 
Published: June 2024

AbstractQualifications for several world championships in sports are organised such that distinct sets of teams play in their own tournament for a predetermined number of slots. Inspired by a recent work studying the problem with the tools from the literature on fair allocation, this paper provides an alternative approach based on historical matches between these sets of teams. We focus on the FIFA World Cup due to the existence of an official rating system and its recent expansion to 48 teams, as well as to allow for a comparison with the already suggested allocations. Our proposal extends the methodology of the FIFA World Ranking to compare the strengths of five confederations. Various allocations are presented depending on the length of the sample, the set of teams considered, as well as the frequency of rating updates. The results show that more European and South American teams should play in the FIFA World Cup. The ranking of continents by the number of deserved slots is different from the ranking implied by FIFA policy. We recommend allocating at least some slots transparently, based on historical performances, similar to the access list of the UEFA Champions League.
The COP9 signalosome stabilized MALT1 promotes Non-Small Cell Lung Cancer progression through activation of NF-κB pathway
Authors: Wang Yinghui , Deng Xuyi , Xie Jing , Lu Tianhao , Qian Rui , Guo Zhi , Zeng Xin , Liao Jing , Ding Zhenhua , Zhou Meijuan , Niu Xinli 
Published: June 2024

AbstractMALT1 has been implicated as an upstream regulator of NF-κB signaling in immune cells and tumors. This study determined the regulatory mechanisms and biological functions of MALT1 in non-small cell lung cancer (NSCLC). In cell culture and orthotopic xenograft models, MALT1 suppression via gene expression interference or protein activity inhibition significantly impaired malignant phenotypes and enhanced radiation sensitivity of NSCLC cells. CSN5, the core subunit of COP9 signalosome, was firstly verified to stabilize MALT1 via disturbing the interaction with E3 ligase FBXO3. Loss of FBXO3 in NSCLC cells reduced MALT1 ubiquitination and promoted its accumulation, which was reversed by CSN5 interference. An association between CSN5/FBXO3/MALT1 regulatory axis and poor prognosis in NSCLC patients was identified. Our findings revealed the detail mechanism of continuous MALT1 activation in NF-κB signaling, highlighting its significance as predictor and potential therapeutic target in NSCLC.
Graphical Abstract
“I start to doubt whether any of my actions will matter”: youth activists’ experiences and expressions of the emotions associated with climate change
Authors: Zurba Melanie , Baum-Talmor Polina , Woodgate Roberta L. , Busolo David , Park Andrew , Mendritzki Erica , Binkley Lisa 
Published: June 2024

AbstractThis study provides insights on the ways that youth express and process the emotions arising from their involvement in climate action. The specific objectives were to: (1) understand the ways youth come to know, conceptualize and reflect on climate change, (2) explore how youth’s emotions in response to climate change impacts their everyday lives; and (3) determine the modalities in which youth are expressing and processing such emotions. We used a grounded theory approach and the photovoice interview method to elicit participant’s views on climate-change-related emotions and interviews were analysed using qualitative data analysis software according to a grounded theory approach. The study resulted in identifying key themes, as well as supports for youth experiencing difficult emotions associated with climate change.
Patterns of Mental Health Service Utilisation: A Population-Based Linkage of Over 17 Years of Health Administrative Records
Authors: Lee Crystal Man Ying , Chai Kevin , McEvoy Peter M. , Graham-Schmidt Kyran , Rock Daniel , Betts Kim S. , Manuel Justin , Coleman Mathew , Meka Shiv , Alati Rosa , Robinson Suzanne 
Published: June 2024

AbstractA cross-sectoral partnership was formed in 2021 in support of the recommendations in an audit on access to state-funded mental health services. In this first paper, we aimed to describe the demographic and service utilisation of adults with a mental health diagnosis in the Western Australian state-funded health system from 2005 to 2021. Inpatient, emergency department, specialised (ambulatory) community mental health service, and death records were linked in individuals aged ≥ 18 years with a mental health diagnosis in Western Australia. Altogether, 392,238 individuals with at least one mental health service contact between 1st January 2005 and 31st December 2021 were included for analysis. Females, Aboriginal and/or Torres Strait Islander people, and those who lived outside major cities or in the most disadvantaged areas were more likely to access state-funded mental health services. While the number of individuals who accessed community mental health services increased over time (from 28,769 in 2005 to 50,690 in 2021), the percentage increase relative to 2005 was notably greater for emergency department attendances (127% for emergency department; 76% for community; and 63% for inpatient). Conditions that contributed to the increase for emergency department were mainly alcohol disorder, reaction to severe stress and adjustment disorders, and anxiety disorders. Sex differences were observed between conditions. The pattern of access increased for emergency department and the community plus emergency department combination. This study confirmed that the patterns of access of state-funded mental health services have changed markedly over time and the potential drivers underlying these changes warrant further investigation.
A Probabilistic Evaluation of Surface Loading and Concentration as Metrics for Post Structural Fire Assessment Soot Sampling Data
Authors: Spicer R. Christopher 
Published: June 2024

AbstractSurface sampling and laboratory analysis for soot/combustion particulates was conducted following a fire at an education/research facility in the southwest United States. This provided a bank of data by which to probabilistically evaluate the behavior of soot loading (counts/mm2) and relative soot concentration (percent ratio; %R) as useful metrics for quantifying differences in soot impact across a building. Surface tape sampling and analysis via light microscopy were conducted via industry standard protocols, and resulting data from various building zones were selected to construct various comparisons. The performance of counts/mm2 and %R as metrics to identify differences in soot impact for each comparison was assessed by comparing inference generated by traditional Student’s t test, Mann Whitney U rank comparison (MW), and the directly calculated axiomatic probability associated with difference in detection (pΔfd). The fourteen (14) comparisons in which a significant difference was inferred via pΔfd was similarly indicated via Student’s t and/or MW in only four (4) instances. Further, approximately one half of the comparisons generated different inference via pΔfd for counts/mm2 and %R, with the former demonstrating better discriminatory ability. In broad view, the heuristic concept of comparing numerical “soot levels” (e.g., average) by either metric was not generally suitable for the distribution of the data. In contrast, pΔfd avoids the statistical bias imposed by traditional statistical inference, and ultimately the efficacy of post fire comparative surface sampling is as dependent upon the metric and inference model utilized as it is on the sampling and laboratory analytical protocols.
From Anekānta-vāda to Sarva-tantra-sva-tantra: Pluralism About Views and Philosophical Systems
Authors: Shevchenko Dimitry 
Published: June 2024

AbstractThis article discusses the unique practice of many philosophers in classical India to write on several philosophical and religious systems, each time adopting a sympathetic point of view for a different tradition. The article describes the development of this phenomenon in the context of interreligious debates between Buddhists, Jains, and Brahmins in the course of three distinct historical periods, transitioning from pluralism about views to pluralism about philosophical systems and culminating in the ideal of sarva-tantra-sva-tantra, a polyvocal philosopher and a polymath. Contrary to such approaches as nihilism, agnosticism, skepticism, and dogmatism, pluralism about views and systems was an attempt to justify the acceptance of several competing schools of thought. The article demonstrates that varieties of pluralism about views and systems played a role in forming and broadening philosophical alliances to defeat religious rivals, but also enhanced the scholarly reputation of erudite thinkers capable of “proving and refuting any system by will.”
Teacher attitudes towards streaming in mathematics education
Authors: Sweeney Amelia , Reid O’Connor Bronwyn 
Published: June 2024

AbstractIn this study, teacher attitudes towards streaming in New South Wales (NSW), Australia were explored. This mixed methods research surveyed 30 secondary mathematics teachers. Findings indicated that NSW teachers had experience teaching both mixed-attainment and streamed mathematics classes, however streaming was the prevalent practice. Teachers believed streaming was the ideal method of grouping students in mathematics, allowing for better management of workloads and resulting in less behavioural issues. Teachers also believed that streaming positively impacted the academic outcomes of perceived high-ability students. However, there were mixed findings in teachers’ beliefs about the overall impacts of streaming on perceived low-ability students. While, teachers felt that streaming was able to better meet the academic needs of perceived low-ability students, the negative impacts of streaming on the wellbeing of these students was also noted. Overall, we argue that findings indicate that further exploration is needed into ways in which streaming can be made more equitable as it appears to currently be an intractable practice in Australia and other international settings.
Both Enantiomers of 2-Hydroxyglutarate Modulate the Metabolism of Cultured Human Neuroblastoma Cells
Authors: Gondáš Eduard , Baranovičová Eva , Bystrický Peter , Šofranko Jakub , Evinová Andrea , Dohál Matúš , Hatoková Zuzana , Murín Radovan 
Published: June 2024

AbstractElevated levels of D-2-hydroxyglutarate (D-2HG) and L-2-hydroxyglutarate (L-2HG) in the brain are associated with various pathological conditions, potentially contributing to neurological symptoms and neurodegeneration. Previous studies on animal models have revealed their capability to interfere with several cellular processes, including mitochondrial metabolism. Both enantiomers competitively inhibit the enzymatic activity of 2-oxoglutarate-dependent dioxygenases. These enzymes also execute several signaling cascades and regulate the level of covalent modifications on nucleic acids or proteins, e.g., methylation, hydroxylation, or ubiquitination, with an effect on epigenetic regulation of gene expression, protein stability, and intracellular signaling. To investigate the potential impact of 2HG enantiomers on human neuronal cells, we utilized the SH-SY5Y human neuroblastoma cell line as a model. We employed proton nuclear magnetic resonance (1H-NMR) spectroscopy of culture media that provided high-resolution insights into the changes in the content of metabolites. Concurrently, we performed biochemical assays to complement the 1H-NMR findings and to estimate the activities of lactate and 3-hydroxybutyrate dehydrogenases. Our results reveal that both 2HG enantiomers can influence the cellular metabolism of human neuroblastoma cells on multiple levels. Specifically, both enantiomers of 2HG comparably stimulate anaerobic metabolism of glucose and inhibit the uptake of several essential amino acids from the culture media. In this respect, both 2HG enantiomers decreased the catabolism capability of cells to incorporate the leucine-derived carbon atoms into their metabolism and to generate the ketone bodies. These results provide evidence that both enantiomers of 2HG have the potential to influence the metabolic and molecular aspects of human cells. Furthermore, we may propose that increased levels of 2HG enantiomers in the brain parenchyma may alter brain metabolism features, potentially contributing to the etiology of neurological symptoms in patients.
A Perron–Frobenius type result in Banach algebras via asymptotic closeness to a cone
Authors: Herzog Gerd , Kunstmann Peer 
Published: June 2024

AbstractFor an element a of a Banach algebra (scaled to spectral radius 1) we prove that the spectral radius is contained in the spectrum, if the sequence of powers $$(a^k)$$

(

a
k

)

is asymptotically not too far from a normal cone.
How does broadband supply affect participation in panel surveys?: Using geospatial broadband data at the district level to analyze mode choice and panel attrition
Authors: Schwerdtfeger Maikel , Bach Ruben L. 
Published: June 2024

AbstractGood broadband supply is crucial for different aspects of participation behavior in web surveys. In this study, we combined geospatial broadband data and the survey data of 16 waves of the mixed-mode GESIS Panel to investigate mode choice and panel attrition. Since small-scale geospatial data is often unavailable or difficult to access for research purposes, we report here results of a feasibility study investigating whether publicly available broadband data at the district level are sufficient to draw meaningful conclusions about participation behavior. In the first part of the analysis, we investigated the effects of broadband supply on mode choice. The results showed a positive effect of the broadband category with the highest coverage rate on choosing the online mode. We also found effects for internet familiarity, age, and education. In the second part, we investigated the effects of broadband supply on panel attrition within the 16 survey waves. We did not find significant effects of broadband supply on panel attrition. However, we found effects for evaluation of duration, measured duration, and age. Overall, we conclude that the granularity of the geospatial data on broadband supply is not ideal. A detailed discussion on the granularity of the broadband data in the context of the general availability of fine-grained geospatial data is provided at the end of this study.