bluuebunny/crossref_metadata_2025_split huggingface dataset:
Understanding Epidemiological Trends in Geriatric Burn Injuries: A National Multicenter Analysis from NEISS 2004-2022
Authors: Boroumand Sam , Katsnelson Beatrice , Dony Alna , Stögner Viola A , Huelsboemer Lioba , Parikh Neil , Oh SeungJu Jackie , Kauke-Navarro Martin , Savetamal Alisa , Pomahac Bohdan 
Published: June 2024

Abstract
Burn injuries pose a significant source of patient morbidity/mortality and reconstructive challenges for burn surgeons, especially in vulnerable populations such as geriatric patients. Our study aims to provide new insights into burn epidemiology by analyzing the largest national, multicenter sample of geriatric patients to date. Using the National Electronic Injury and Surveillance System (NEISS) database (2004-2022), individuals with a “burn” diagnosis were extracted and divided into 2 comparison age groups of 18-64 and 65+. Variables including sex, race, affected body part, incident location, burn etiology, and clinical outcomes were assessed between the 2 groups using 2 proportion z-tests. About 60,581 adult patients who sustained burns were identified from the NEISS database with 6630 of those patients categorized as geriatric (65+). Geriatric patients had a significantly greater frequency of scald burns (36.9% vs 35.4%; P &lt; .01), and third-degree/full-thickness burns (10.4% vs 5.5%, P &lt; .01) relative to nongeriatric adult patients with most of these burns occurring at home (75.9% vs 67.4%; P &lt; .01). The top 5 burn sites for geriatric patients were the hand, face, foot, lower arm, and lower leg and the top 5 burn injury sources were hot water, cookware, oven/ranges, home fires, and gasoline. Geriatric patients had over 2 times greater risk of hospital admission (odds ratio [OR]: 2.32, 95% CI: 2.17-2.49, P &lt; .01) and over 5 times greater risk of emergency department mortality (OR: 6.22, 95% CI: 4.00-9.66, P &lt; .01) after incurring burn injuries. These results highlight the need for stronger awareness of preventative measures for geriatric burn injuries.
Ultrasonic velocity anisotropy of Jurassic shales with different lithofacies
Authors: Liu Weihua , Wang Yang , Shen Hui , Li Min , Fan Wenhao 
Published: June 2024

AbstractGiven the growing importance of organic-rich shale as unconventional reservoirs, a thorough understanding of the elastic and anisotropic behavior of shales is of great concern. However, for lacustrine shales, the complex lithofacies assemblage with geological deposition makes it challenging. Four lithofacies (argillaceous, mixed, siliceous, and calcareous) are recognized for 40 lacustrine shale samples from Jurassic formation in Sichuan Basin on the basis of their mineral compositions. We perform ultrasonic velocity measurements on 40 pairs of shale plugs at varied confining pressures, attempting to uncover the controls on the anisotropic properties of different lithofacies. The experimental results reveal that the total porosity, clay, and organic matter would positively contribute to velocity anisotropy of Jurassic shales. Combined with microstructure and pressure-dependent velocity analysis, the preferred orientations of platy clay particles and lenticular kerogen, the development of clay pores along clay fabric, and the sub-parallel micro-cracks induced by hydrocarbon expulsion are treated to be the controlling mechanisms. We add the total porosity, clay content, and kerogen volume together, intending to distinguish the elastic and anisotropic properties of four lithofacies. Generally, argillaceous shales, the dominant lithofacies in Jurassic formation, could be characterized by the highest clay and total organic content (TOC), the lowest bedding-normal velocities, and the strongest velocity anisotropy. Finally, with the laboratory data, two rock-physics-driven exponential relationships are proposed to predict the P- and S-wave velocity anisotropy with the bedding-normal velocities.
Cellular metabolism and hypoxia interfacing with allergic diseases
Authors: Kellett Shauna K , Masterson Joanne C 
Published: June 2024

Abstract
Allergic diseases display significant heterogeneity in their pathogenesis. Understanding the influencing factors, pathogenesis, and advancing new treatments for allergic diseases is becoming more and more vital as currently, prevalence continues to rise, and mechanisms of allergic diseases are not fully understood. The upregulation of the hypoxia response is linked to an elevated infiltration of activated inflammatory cells, accompanied by elevated metabolic requirements. An enhanced hypoxia response may potentially contribute to inflammation, remodeling, and the onset of allergic diseases. It has become increasingly clear that the process underlying immune and stromal cell activation during allergic sensitization requires well-tuned and dynamic changes in cellular metabolism. The purpose of this review is to examine current perspectives regarding metabolic dysfunction in allergic diseases. In the past decade, new technological platforms such as “omic” techniques have been applied, allowing for the identification of different biomarkers in multiple models ranging from altered lipid species content, increased nutrient transporters, and altered serum amino acids in various allergic diseases. Better understanding, recognition, and integration of these alterations would increase our knowledge of pathogenesis and potentially actuate a novel repertoire of targeted treatment approaches that regulate immune metabolic pathways.
Repellency ofN,N-diethyl-3-methylbenzamide (DEET) during host-seeking behavior of bed bugs (Hemiptera: Cimicidae) in binary choice olfactometer assays
Authors: Hayes Christopher C , Schal Coby 
Published: June 2024

AbstractThe bed bug (Cimex lectularius L.) is one of the most prolific and burdensome indoor pests, and suppression of bed bug populations is a global priority. Understanding bed bug behavior is important to the development of new tactics for their control. Major gaps exist in our understanding of how host cues, insecticide resistance, and exposure modality impact the repellency of formulated products to bed bugs. Here, we validate the use of a binary choice olfactometer for assessing bed bug repellency behaviors using N,N-diethyl-3-methylbenzamide (DEET) in a dose-dependent manner, while considering the role of host-associated stimuli (with vs. without CO2), exposure modality (olfactory vs. olfactory and contact), and resistance status (susceptible vs. resistant) on repellency. We observed that host-seeking insecticide-susceptible bed bugs were repelled only when olfactorily exposed to high concentrations of DEET. However, exposure to DEET by contact repelled insecticide-susceptible bed bugs at 100-fold lower dose of DEET. Further, we demonstrate for the first time that insecticide-resistant bed bugs were significantly more responsive to DEET than susceptible bed bugs. We conclude that the 2-choice olfactometer is an effective tool for assessing the behavioral responses of bed bugs to spatial and contact repellents.
Preliminary result of combined treatment with scanning carbon-ion radiotherapy and image-guided brachytherapy for locally advanced cervical adenocarcinoma
Authors: Tsuchida Keisuke , Yoshida Daisaku , Shima Satoshi , Kusunoki Terufumi , Takayama Yoshiki , Koge Hiroaki , Kano Kio , Takakusagi Yosuke , Mizoguchi Nobutaka , Kamada Tadashi , Kusano Yohsuke , Kato Hisamori , Katoh Hiroyuki 
Published: June 2024

Abstract
Although there is growing evidence of the efficacy of carbon-ion radiotherapy (CIRT) for locally advanced cervical adenocarcinoma, reports on combined treatment with CIRT and image-guided brachytherapy (IGBT) are scarce. We retrospectively analyzed patients with International Federation of Gynecology and Obstetrics (2008) stage II–IVA locally advanced cervical adenocarcinoma who received combined scanning CIRT (sCIRT) and IGBT between April 2019 and March 2022. sCIRT consisted of whole-pelvic irradiation with 36 Gy (relative biological effectiveness [RBE]) in 12 fractions and subsequent local boost irradiation with 19.2 Gy (RBE) in 4 fractions. Three sessions of IGBT were administered after completion of sCIRT. Concurrent chemotherapy using weekly cisplatin (40 mg/m2/week) was also administered. Efficacy, toxicity and dose–volume parameters were analyzed. Fifteen patients were included in the analysis. The median follow-up period was 25 months. The 2-year overall survival, progression-free survival and local control rates were 92.3% (95% confidence interval [CI] = 77.8–100%), 52.5% (95% CI = 26.9–78.1%) and 84.8% (95% CI = 65.2–100%), respectively. Neither severe acute toxicity necessitating treatment cessation nor grade 3 or higher late toxicity were observed. The sigmoid D2cm3 of the patient who developed grade 2 late sigmoid hemorrhage was 65.6 Gy, which exceeded the standard deviation and target dose. The combination of sCIRT and IGBT for locally advanced cervical adenocarcinoma showed acceptable efficacy and safety. Further large-scale and long-term studies are warranted to confirm the efficacy and safety of this treatment.
MeerKAT discovery of a double radio relic and odd radio circle: connecting cluster and galaxy merger shocks
Authors: Koribalski Bärbel S , Veronica Angie , Dolag Klaus , Reiprich Thomas H , Brüggen Marcus , Heywood Ian , Andernach Heinz , Dettmar Ralf-Jürgen , Hoeft Matthias , Zhang Xiaoyuan , Bulbul Esra , Garrel Christian , Józsa Gyula I G , English Jayanne 
Published: June 2024

ABSTRACT
We present the serendipitous discovery of (1) a large double radio relic associated with the galaxy cluster PSZ2 G277.93 + 12.34 and (2) a new odd radio circle, ORC J1027–4422, both found in the same deep MeerKAT 1.3 GHz wide-band radio continuum image. The angular separation of the two arc-shaped cluster relics is ∼16 arcmin or ∼2.6 Mpc for a cluster redshift of z ≈ 0.158. The thin southern relic, which shows several ridges/shocks including one possibly moving inwards, has a linear extent of ∼1.64 Mpc. In contrast, the northern relic is about twice as wide, twice as bright, but only has a largest linear size of ∼0.66 Mpc. Complementary SRG/eROSITA X-ray images reveal extended emission from hot intracluster gas between the two relics and around the narrow-angle tail (NAT) radio galaxy PMN J1033–4335 (z ≈ 0.153) located just east of the northern relic. The radio morphologies of the NAT galaxy and the northern relic, which are also detected with the Australian Square Kilometer Array Pathfinder (ASKAP) at 888 MHz, suggest both are moving in the same outward direction. The discovery of ORC J1027–4422 in a different part of the same MeerKAT image makes it the fourth known single ORC. It has a diameter of ∼90 arcsec corresponding to 400 kpc at a tentative redshift of z ≈ 0.3 and remains undetected in X-ray emission. Supported by simulations, we discuss similarities between outward moving galaxy and cluster merger shocks as the formation mechanisms for ORCs and radio relics, respectively.
How to break the mass sheet degeneracy with the light curves of microlensed Type Ia supernovae
Authors: Weisenbach Luke , Collett Thomas , de Murieta Ana Sainz , Krawczyk Coleman , Vernardos Georgios , Enzi Wolfgang , Lundgren Andrew 
Published: June 2024

ABSTRACT
The standardizable nature of gravitationally lensed Type Ia supernovae (glSNe Ia) makes them an attractive target for time-delay cosmography, since a source with known luminosity breaks the mass sheet degeneracy. It is known that microlensing by stars in the lensing galaxy can add significant stochastic uncertainty to the unlensed luminosity, which is often much larger than the intrinsic scatter of the Type Ia population. In this work, we show how the temporal microlensing variations as the supernova (SN) disc expands can be used to improve the standardization of glSNe Ia. We find that SNe are standardizable if they do not cross caustics as they expand. We estimate that this will be the case for ≈6 doubly imaged systems and ≈0.3 quadruply imaged systems per year from the Vera Rubin Observatory (LSST). At the end of the 10 yr LSST survey, these systems should enable us to test for systematics in H0 due to the mass sheet degeneracy at the $1.00^{+0.07}_{-0.06}$ per cent level, or 1.8 ± 0.2 per cent if we can only extract time delays from the third of systems with counter-images brighter than i = 24 mag.
Historic dog Furs Unravel the Origin and Artificial Selection of Modern Nordic Lapphund and Elkhound dog Breeds
Authors: Wang Shi-Zhi , Yan Yu , Widlund Malin , Qian Chen-Chang , Zhang Liang-Liang , Zhang Shao-Jie , Li Zi-Mai , Cao Peng , Dai Qing-Yan , Feng Xiao-Tian , Liu Feng , Wang Lu , Gao Chao , Fu Qiao-Mei , Hytönen Marjo K , Lohi Hannes , Savolainen Peter , Wang Guo-Dong 
Published: June 2024

Abstract
The origins and extreme morphological evolution of the modern dog breeds are poorly studied because the founder populations are extinct. Here, we analyse eight 100 to 200 years old dog fur samples obtained from traditional North Swedish clothing, to explore the origin and artificial selection of the modern Nordic Lapphund and Elkhound dog breeds. Population genomic analysis confirmed the Lapphund and Elkhound breeds to originate from the local dog population, and showed a distinct decrease in genetic diversity in agreement with intense breeding. We identified eleven genes under positive selection during the breed development. In particular, the MSRB3 gene, associated with breed-related ear morphology, was selected in all Lapphund and Elkhound breeds, and functional assays showed that a SNP mutation in the 3′UTR region suppresses its expression through miRNA regulation. Our findings demonstrate analysis of near-modern dog artifacts as an effective tool for interpreting the origin and artificial selection of the modern dog breeds.
Prediction of WHO grade and methylation class of aggressive meningiomas: Extraction of diagnostic information from infrared spectroscopic data
Authors: Galli Roberta , Lehner Franz , Richter Sven , Kirsche Katrin , Meinhardt Matthias , Juratli Tareq A , Temme Achim , Kirsch Matthias , Warta Rolf , Herold-Mende Christel , Ricklefs Franz L , Lamszus Katrin , Sievers Philipp , Sahm Felix , Eyüpoglu Ilker Y , Uckermann Ortrud 
Published: June 2024

Abstract

Background
Infrared (IR) spectroscopy allows intraoperative, optical brain tumor diagnosis. Here, we explored it as a translational technology for the identification of aggressive meningioma types according to both, the WHO CNS grading system and the methylation classes (MC).

Methods
Frozen sections of 47 meningioma were examined by IR spectroscopic imaging and different classification approaches were compared to discern samples according to WHO grade or MC.

Results
IR spectroscopic differences were more pronounced between WHO grade 2 and 3 than between MC intermediate and MC malignant, although similar spectral ranges were affected. Aggressive types of meningioma exhibited reduced bands of carbohydrates (at 1024 cm−1) and nucleic acids (at 1080 cm−1), along with increased bands of phospholipids (at 1240 and 1450 cm−1). While linear discriminant analysis was able to discern spectra of WHO grade 2 and 3 meningiomas (AUC 0.89), it failed for MC (AUC 0.66). However, neural network classifiers were effective for classification according to both WHO grade (AUC 0.91) and MC (AUC 0.83), resulting in the correct classification of 20/23 meningiomas of the test set.

Conclusions
IR spectroscopy proved capable of extracting information about the malignancy of meningiomas, not only according to the WHO grade, but also for a diagnostic system based on molecular tumor characteristics. In future clinical use, physicians could assess the goodness of the classification by considering classification probabilities and cross-measurement validation. This might enhance the overall accuracy and clinical utility, reinforcing the potential of IR spectroscopy in advancing precision medicine for meningioma characterization.
Differential isocitrate dehydrogenase 1 and isocitrate dehydrogenase 2 mutation-related landscape in intrahepatic cholangiocarcinoma
Authors: Xu Shuaishuai , Cao Linping , Chen Ruyin , Ye Chanqi , Li Qiong , Jiang Qi , Yan Feifei , Wan Mingyu , Zhang Xiaochen , Ruan Jian 
Published: June 2024

Abstract

Background
Patients with intrahepatic cholangiocarcinoma (ICC) are prone to recurrence and poor survival. Targeted therapy related to isocitrate dehydrogenase (IDH) is an extremely important treatment. IDH1 and IDH2 mutations are generally thought to have similar effects on the tumor landscape. However, it is doubtful whether these 2 mutations have exactly the same effects on tumor cells and the tumor microenvironment.

Methods
All collected tumor samples were subjected to simultaneous whole-exon sequencing and proteome sequencing.

Results
IDH1 mutations accounted for 12.2%, and IDH2 mutations accounted for 5.5%, all missense mutations. Tumors with IDH mutations had lower proportions of KRAS and TP53 mutations. Mutated genes were obviously enriched in the kinase pathway in the tumors with IDH2 mutations. The signaling pathways were mainly enriched in the activation of cellular metabolic activities and an increase of inhibitory immune cells in the tumors with IDH mutations. Moreover, tumors had unique enrichment in DNA repair in IDH1 mutants and secretion of biological molecules in IDH2 mutants. Inhibitory immune cells might be more prominent in IDH2 mutants, and the expression of immune checkpoints PVR and HLA-DQB1 was more prominent in IDH1 mutants. IDH mutants were more related to metabolism-related and inflammation-immune response clusters, and some belonged to the DNA replication and repair cluster.

Conclusions
These results revealed the differential IDH1 and IDH2 mutation-related landscapes, and we have provided an important reference database to guide ICC treatment.
Future sea-level rise in northwest Mexico is projected to decrease the distribution and habitat quality of the endangered Calidris canutus roselaari (Red Knot)
Authors: Garcia-Walther Julian , Johnson James A , Senner Nathan R 
Published: June 2024

Abstract
Sea-level rise (SLR) is one of the most unequivocal consequences of climate change, yet the implications for shorebirds and their coastal habitats are not well understood, especially outside of the north temperate zone. Here, we show that by the year 2050, SLR has the potential to cause significant habitat loss and reduce the quality of the remaining coastal wetlands in Northwest Mexico—one of the most important regions for Nearctic breeding migratory shorebirds. Specifically, we used species distribution modeling and a moderate SLR static inundation scenario to assess the effects of future SLR on coastal wetlands in Northwest Mexico and the potential distribution of Calidris canutus roselaari (Red Knot), a threatened long-distance migratory shorebird. Our results suggest that under a moderate SLR scenario, 55% of the current coastal wetland extent in northwest Mexico will be at risk of permanent submergence by 2050, and the high-quality habitat areas that remain will be 20% less suitable for C. c. roselaari. What is more, 8 out of the 10 wetlands currently supporting the largest numbers of C. c. roselaari are predicted to lose, on average, 17.8% of their Highly Suitable Habitat (HSH) areas, with 2 sites completely losing all of their HSH. In combination with increasing levels of coastal development and anthropogenic disturbance in Northwest Mexico, these predicted changes suggest that the potential future distribution of C. c. roselaari (and other shorebirds) will likely contract, exacerbating their ongoing population declines. Our results also make clear that SLR will likely have profound effects on ecosystems outside the north temperate zones, providing a clarion call to natural resource managers. Urgent action is required to begin securing sufficient space to accommodate the natural capacity of wetlands to migrate inland and implement local-scale solutions that strengthen the resilience of wetlands and human populations to SLR.
Association between early-life mosquito repellents exposure and ADHD-like behaviours
Authors: Zhou Cheng , Fu Weiwen , Wei Xinyu , Zhang Zixing , Wang Bin , Fang Xinyu 
Published: June 2024

Abstract

Background
Limited research has explored the impact of mosquito repellents exposure during early life on ADHD symptoms. This study aimed to explore the associations of exposure to mosquito repellents from pregnancy to 3 years old and the prevalence of ADHD-like behaviours among children aged 3–9 years, and further identify the sensitive exposure period.

Methods
A cross-sectional study was conducted, including 12 275 children in Hefei City, China. Exposure was self-reported via primary caregivers. ADHD-like behaviours were measured by the Swanson, Nolan and Pelham, version IV scale (SNAP-IV), and Conners’ Parent Rating Scale (CPRS). Cross-over analysis, binary logistic regression and linear regression were employed.

Results
After adjusting for confounding variables, early-life exposure to mosquito repellents was associated with a higher risk of ADHD-like behaviours (OR = 1.81, 95% CI = 1.49–2.19). By comparing the strength of the association for each subgroup, we found exposure during 1–3 years old was a sensitive period (OR = 1.89, 95% CI = 1.25–2.87) by the cross-over analysis. Furthermore, we found a dose–response relationship in which the likelihood of ADHD-like behaviours increased with children’s early-life mosquito repellents exposure dose.

Conclusions
Early-life exposure to mosquito repellents is linked with an elevated risk of ADHD-like behaviours in children, with a sensitive period identified during 1–3 years old.
Cervical Cancer Screening Among Female Medicaid Beneficiaries With and Without Schizophrenia
Authors: Hwong Alison R , Murphy Karly A , Vittinghoff Eric , Alonso-Fraire Paola , Crystal Stephen , Walkup Jamie , Hermida Richard , Olfson Mark , Cournos Francine , Sawaya George F , Mangurian Christina 
Published: June 2024

Abstract

Background and Hypothesis
In the United States, women with schizophrenia face challenges in receiving gynecologic care, but little is known about how cervical cancer screening rates vary across time or states in a publicly insured population. We hypothesized that women Medicaid beneficiaries with schizophrenia would be less likely to receive cervical cancer screening across the United States compared with a control population, and that women with schizophrenia and other markers of vulnerability would be least likely to receive screening.

Study Design
This retrospective cohort study used US Medicaid administrative data from across 44 states between 2002 and 2012 and examined differences in cervical cancer screening test rates among 283 950 female Medicaid beneficiaries with schizophrenia and a frequency-matched control group without serious mental illness, matched on age and race/ethnicity. Among women with schizophrenia, multivariable logistic regression estimated the odds of receiving cervical cancer screening using individual sociodemographics, comorbid conditions, and health care service utilization.

Study Results
Compared to the control group, women with schizophrenia were less likely to receive cervical cancer screening (OR = 0.76; 95% CI 0.75–0.77). Among women with schizophrenia, nonwhite populations, younger women, urban dwellers, those with substance use disorders, anxiety, and depression and those connected to primary care were more likely to complete screening.

Conclusions
Cervical cancer screening rates among US women Medicaid beneficiaries with schizophrenia were suboptimal. To address cervical cancer care disparities for this population, interventions are needed to prioritize women with schizophrenia who are less engaged with the health care system or who reside in rural areas.