bluuebunny/crossref_metadata_2025_split huggingface dataset:
Psychiatric morbidity among the patients of first ever ischemic stroke
Authors: Inam Muhammad Sayed , Roy Polash , Rahaman Motiur , Dey Gopal Sankar 
Published: May 2024

Ischemic stroke is one of the leading causes of mortality and morbidity worldwide and third common cause of death in developed countries which consumes annually a great cost, directly or indirectly and stroke produces a wide range of psychiatric disorders. This was a cross sectional study, conducted in the department of Psychiatry, Sylhet MAG Osmani Medical College Hospital, Sylhet during the period from 1 July 2013 to 30 June 2014 to evaluate the psychiatric morbidity among the patients of first ever ischemic stroke. For this purpose, 66 ischemic stroke patients of first attack between 2 weeks to 2 years of stroke, aged above 18 years irrespective of sex and 66 accompanying healthy persons of the patients and other patients without any kind of stroke matching age and sex fulfilling inclusion and exclusion criteria were taken in Group[1]A and Group-B respectively. Psychiatric assessment was done using General Health Questionnaire (GHQ12) as a screening tool and all GHQ12 positive cases were evaluated using mental state examination. Diagnoses of psychiatric disorders of all respondents were confirmed by psychiatrist according to Diagnostic and statistical manual of mental disorders (DSM) 5 criteria. Ethical issues were maintained properly and an informed written consent was taken from every patient. After collecting data, editing was done manually and was analyzed with statistical package for social sciences (SPSS) version 21. The result showed that, the mean age of the respondents was 57.6 (SD±5.5) years which was almost identical to control group (p=0.130). Most (87.9%) of the patient were below the age of 65 years. Co-morbid psychiatric disorder was found in (34.8%) patients with ischemic stroke and (13.6%) control subjects (p=0.004). The most common psychiatric disorder was generalized anxiety disorder (13.6%) and major depressive disorder (21.2%) in ischemic stroke group. The results of this study suggested that, a significant number of patients with ischemic stroke were suffering from psychiatric disorders than the age and sex matched control.
Bang J Psychiatry 2022;36(1):11-17
A case report of somatic symptom disorder with suicidal tendencies
Authors: Aziz Saqiba , Shahriar Shihab , Arifuzzaman Md 
Published: May 2024

Chronic illnesses, such as Parkinson’s disease, are often associated with a wide variety of psychiatric illnesses such, somatic symptom disorder. The presentation and severity of complaints associated with somatic symptoms vary, but rarely do they cause the patient such distress that they attempt to commit suicide, as a result of being unable to cope with the discomfort. In such cases, there is a diagnostic dilemma of whether these are cases of somatic symptom disorder or mood disorder. Herein, we will discuss a case where a 65 year old retiree, suffering from Parkinson’s disease was admitted this in hospital, after multiple suicide attempts. We eventually excluded major depressive disorder as a diagnosis, and we treated the patient as a case of somatic symptom disorder. He was treated with selective nor-epinephrine reuptake inhibitor and psychotherapy (including relaxation therapy), with which he responded well. The case report supports previous studies which have found that medication and psychotherapy aid in the improvement of the condition of such patients.
Bang J Psychiatry 2022;36(1):21-23
Socio-demographic variation among the elderly people living in old care home
Authors: Harun HM Mahmud , Shah Mohsin Ali , Mullick MSI , Ahmed Ahsan Uddin , Hasan Md Mahbub , Solaiman Mahjabeen Aftab 
Published: May 2024

The older population is rapidly growing throughout the world. Bangladesh has a long cultural and religious tradition of looking after the elderly and it is expected that families and communities will care for their own elderly members. But rapid socioeconomic and demographic transitions, mass poverty, changing social and religious values, influence of western culture, and other factors have broken down the traditional extended family and community care system. Most of the elderly people in Bangladesh suffer from some basic human problems, such as poor financial support, senile diseases, and absence of proper health and medicine facilities, exclusion and negligence, deprivation, and socioeconomic insecurity. Increase care based on socio-demographic variation may be more able to improve the quality of life of elderly people as well as old care home residents. This cross-sectional study was done to find out the socio demographic variation among 138 elderly respondents irrespective of sex living two different old care homes of Bangladesh from January 2018 to September 2019. They were interviewed with a socio-demographic questionnaire. The results showed that, the mean age of the respondents was 70.83±8.28 years and more than half (54.35%) of the respondents were 60-69 years of old. The respondents were predominantly male (58.7%). with male to female ratio being roughly 3:2. More than half of the respondents (52.2%) were from urban background and rest (47.8%) were from rural background. Nearly three quarters (87.7%) of the respondents were Muslim and 8.7% were Hindus. More than 50% had monthly family income of <10000 Bangladeshi taka (BDT). Majorities (70.3%) of the respondents were widow/widower and 10.9% were single. Over one third (38.4%) of the respondents were studied up to primary level, 26.8% were graduated, 14.5% were studied up to secondary level and 11.6% up to higher secondary level. A few respondents were illiterate (8.7%). Most of them came from nuclear family (79.7%). and rests were from joint family (20.3%). It was seen that, single or widower urban male people from nuclear family were more coming in the old care home. Majority (60.9%) of the respondents had chronic physical illness. A few of the respondents had family history of mental illness (7.2%). Only 1.4% had history of drug addiction. The mean duration with standard deviation of staying in old care home by the respondents was 4.145±3.35 years.
Bang J Psychiatry 2022;36(2): 35-38
Aplicación del AH inyectable como terapia para la regeneración de las papilas interdentales: Una revisión bibliográfica
Authors: Urgiles Espinoza Karen Anais , Rosales Calderón Jennifer Alexandra , Martinez Peraza Valentina 
Published: May 2024

Objetivo: Esta revisión bibliográfica tiene como objetivo evaluar la eficacia de la aplicación del gel de Ácido Hialurónico (HA) inyectable como terapia para la regeneración de las papilas interdentales deficientes. Metodología: Se utilizó la estrategia framework SALSA, realizando una búsqueda en cuatro bases de datos digitales: Ebsco, PubMed, Science Direct y Scielo, donde se recolectaron artículos en inglés y español, publicados en los últimos cinco años (2018-2023). Resultados: Se incluyeron dieciocho estudios con un total de 213 participantes y 696 defectos papilares interdentales. Todos los estudios incluidos informaron resultados prometedores sobre la reconstrucción de la papila interdental deficiente después de la inyección de HA. Conclusión: El análisis a corto plazo indicó que la inyección de HA para el tratamiento de defectos papilares se considera un tratamiento factible logrando resultados estéticos satisfactorios con mínimo dolor. Sin embargo, se deben recomendar más estudios ECA bien realizados con parámetros estandarizados y seguimiento a largo plazo.
Perempuan Jemaat HKBP Duren Jaya Bekasi: Tatakelola Hidup Sehat, Bugar dan Bijak Menggunakan Kosmetik
Authors: Sihotang Hotmaulina , Nadeak Bernadetha , Siagian Carmen , Sinaga Dameria , Siregar Rospita , Samaloisa Benhur 
Published: May 2024

Sebagai implementasi kerjasama UKI dengan HKBP Duren Jaya bekasi dan berkaitan dengan hari Kartini 21 April 2024, jemaat perempuan HKBP Duren Jaya membuat program seminar dan juga sejalan dengan kegiatan pengabdian kepada masyarakat (PkM) UKI. Metode PkM dengan seminar yang dihadiri pendeta, majelis gereja dan jemaat berempuan berjumlah 86 orang. Jemaat perempuan bervariasi ditinjau dari aspek umur, sosial dan ekonomi. Jemaat perempuan terdiri dari perempuan yang masih aktif bekerja, ibu rumah tangga, perempuan yang sudah pensiun yang sehari-hari menjaga cucu, aktif kegiatan di gereja, paduan suara, pesta adat, dan lain-lain. Oleh karena itu jemaat perempuan memiliki harapan tetap sehat, bugar, cantik agar bisa aktif dalam kegiatannya sehari-hari. Peserta sangat antusias menyimak dan bertanya tentang kesehatan, gizi dan kebugaran sesuai dengan kondisi dan permasalahan yang dialami. Adapun hasil setelah seminar jemaat memiliki pemahaman pada intinya kesehatan dipengaruhi empat faktor yakni lingkungan, perilaku, layanan kesehatan dan gen. Hidup sehat harus memperhatikan gizi yang seimbang dengan kondisi masing-masing bonusnya cantik. Agar kulit tetap cantik maka yang perlu adalah membersihkan kulit, memberi pelembab dan memakai skin cara yang aman.

Kata kunci: sehat, bugar, kosmetik, perempuan.
Association between the atherogenic index of plasma and bone mineral density among adult women: NHANES (2011–2018)
Authors: He Qiwang , Chen Bo , Liang Fuchao , Zhang Zhiwen 
Published: May 2024

BackgroundStudies on the relationship between the atherogenic index of plasma (AIP) and bone mineral density (BMD) among adult women in the United States are limited. The purpose of this study was to explore this association using a sizable, nationally representative sample.MethodsData from the 2011 to 2018 National Health and Nutrition Examination Survey (NHANES) were used in this observational study. The AIP was computed as log10 (triglycerides/high-density lipoprotein cholesterol). Total BMD was measured via dual-energy X-ray densitometry. We constructed multiple linear regression models to evaluate the correlation between the AIP and BMD. The non-linear relationship was characterized by smooth curve fitting and generalized additive models. We also conducted subgroup and interaction analyses.ResultsIn this study, we included 2,362 adult women with a mean age of 38.13 ± 12.42 years. The results of multiple linear regression analysis, the AIP and total BMD showed a negative association (β = −0.021, 95%CI: −0.037, −0.006). The curve fitting analysis and threshold effect analysis showed a non-linear relationship between the two variables, and the inflection point of the AIP was found to be -0.61. The total BMD decreased significantly when the AIP reached this value (β = −0.03, 95%CI: −0.04, −0.01). The results of the subgroup analysis showed that AIP and total BMD had a strong negative relationship in participants who were below 45 years old (β = -0.023; 95% CI: -0.041, -0.004), overweight (BMI ≥ 25 kg/m2) (β = -0.022; 95% CI: -0.041, -0.002), had a higher education level (β = -0.025; 95% CI: -0.044, -0.006), and had no partners (β = -0.014; 95% CI: -0.06, -0.009).ConclusionsWe found a negative correlation between the AIP and total BMD. Clinicians should pay attention to patients with high AIP, which might indicate a low BMD and has reference significance in preventing osteoporosis.
The associations of maternal liver biomarkers in early pregnancy with the risk of gestational diabetes mellitus: a prospective cohort study and Mendelian randomization analysis
Authors: Liu Hui , Zhang Libi , Cheng Haoyue , Chi Peihan , Zhuang Yan , Alifu Xialidan , Zhou Haibo , Qiu Yiwen , Huang Ye , Ainiwan Diliyaer , Si Shuting , Yu Yunxian 
Published: May 2024

BackgroundAssociations of liver function with the risk of gestational diabetes mellitus (GDM) remain unclear. This study aimed to examine the relationship and the potential causality between maternal liver biomarkers and the risk of subsequent GDM, as well as to evaluate the interaction between liver biomarkers and lipids on GDM risk.MethodsIn an ongoing Zhoushan Pregnant Women Cohort, pregnant women who finished the first prenatal follow-up record, underwent liver function tests in early pregnancy, and completed the GDM screening were included in this study. Logistic regression models were used to investigate the association, and the inverse-variance weighted method supplemented with other methods of two-sample Mendelian randomization (MR) analysis was applied to deduce the causality.ResultsAmong 9,148 pregnant women, 1,668 (18.2%) developed GDM. In general, the highest quartile of liver function index (LFI), including ALT, AST, GGT, ALP, and hepatic steatosis index, was significantly associated with an increased risk of GDM (OR ranging from 1.29 to 3.15), especially an elevated risk of abnormal postprandial blood glucose level. Moreover, the causal link between ALT and GDM was confirmed by the MR analysis (OR=1.28, 95%CI:1.05-1.54). A significant interaction between AST/ALT and TG on GDM risk was observed (Pinteraction = 0.026).ConclusionElevated levels of LFI in early pregnancy were remarkably associated with an increased risk of GDM in our prospective cohort. Besides, a positive causal link between ALT and GDM was suggested.
A ferritin nanoparticle vaccine based on the hemagglutinin extracellular domain of swine influenza A (H1N1) virus elicits protective immune responses in mice and pigs
Authors: Tang Pan , Cui Enhui , Cheng Jinghua , Li Benqiang , Tao Jie , Shi Ying , Jiao Jiajie , Du Enqi , Wang Jingyu , Liu Huili 
Published: May 2024

IntroductionSwine influenza viruses (SIVs) pose significant economic losses to the pig industry and are a burden on global public health systems. The increasing complexity of the distribution and evolution of different serotypes of influenza strains in swine herds escalates the potential for the emergence of novel pandemic viruses, so it is essential to develop new vaccines based on swine influenza.MethodsHere, we constructed a self-assembling ferritin nanoparticle vaccine based on the hemagglutinin (HA) extracellular domain of swine influenza A (H1N1) virus using insect baculovirus expression vector system (IBEVS), and after two immunizations, the immunogenicities and protective efficacies of the HA-Ferritin nanoparticle vaccine against the swine influenza virus H1N1 strain in mice and piglets were evaluated.ResultsOur results demonstrated that HA-Ferritin nanoparticle vaccine induced more efficient immunity than traditional swine influenza vaccines. Vaccination with the HA-Ferritin nanoparticle vaccine elicited robust hemagglutinin inhibition titers and antigen-specific IgG antibodies and increased cytokine levels in serum. MF59 adjuvant can significantly promote the humoral immunity of HA-Ferritin nanoparticle vaccine. Furthermore, challenge tests showed that HA-Ferritin nanoparticle vaccine conferred full protection against lethal challenge with H1N1 virus and significantly decreased the severity of virus-associated lung lesions after challenge in both BALB/c mice and piglets.ConclusionTaken together, these results indicate that the hemagglutinin extracellular-based ferritin nanoparticle vaccine may be a promising vaccine candidate against SIVs infection.
The effect of gD-derived peptides on T cell immune response mediated by BTLA-HVEM protein complex in melanoma patients
Authors: Wojciechowicz Karolina , Kuncewicz Katarzyna , Rutkowski Jacek , Jassem Jacek , Wardowska Anna , Spodzieja Marta 
Published: May 2024

IntroductionThe effector function of T cells is regulated via immune checkpoints, activating or inhibiting the immune response. The BTLA-HVEM complex, the inhibitory immune checkpoint, may act as one of the tumor immune escape mechanisms. Therefore, interfering with the binding of these proteins can prove beneficial in cancer treatment. Our study focused on peptides interacting with HVEM at the same place as BTLA, thus disrupting the BTLA-HVEM interaction. These peptides’ structure and amino acid sequences are based on the gD protein, the ligand of HVEM. Here, we investigated their immunomodulatory potential in melanoma patients.MethodsFlow cytometry analyses of activation, proliferation, and apoptosis of T cells from patients were performed. Additionally, we evaluated changes within the T cell memory compartment.ResultsThe most promising compound – Pep(2), increased the percentages of activated T cells and promoted their proliferation. Additionally, this peptide affected the proliferation rate and apoptosis of melanoma cell line in co-culture with T cells.DiscussionWe conclude that the examined peptide may act as a booster for the immune system. Moreover, the adjuvant and activating properties of the gD-derived peptide could be used in a combinatory therapy with currently used ICI-based treatment. Our studies also demonstrate that even slight differences in the amino acid sequence of peptides and any changes in the position of the disulfide bond can strongly affect the immunomodulatory properties of compounds.
Therapeutic potential of single-nucleotide polymorphism-mediated IL6R inhibitors in ankylosing spondylitis treatment
Authors: Chen Ding-Qiang , Xu Wen-Bin , Que Zhi-Qiang , Xiao Ke-Yi , Sun Nai-Kun , Cai Di-Xin , Feng Jin-Yi , Rui Gang 
Published: May 2024

ObjectiveInterleukin-6 (IL-6) is a multiple-effect cell factor implicated in the etiopathogenesis of several rheumatologic disorders. The blockade of the IL-6 pathway via IL6R inhibitors effectively treats these disorders. However, the clinical significance of the IL6R blockade for ankylosing spondylitis (AS) therapy remains controversial. With advances in genomics, increasing evidence has revealed the role of heritability in the etiology of disease, and Mendelian randomization (MR) analyses are being used more broadly to infer causation. Therefore, this MR study aims to evaluate the potential therapeutic utility of IL6R-targeted approaches in AS.MethodsThe C-reactive protein (CRP) level was used as an exposure factor, and rheumatoid arthritis (RA) was used as a positive control. As-related genome-wide association study (GWAS) data were used as the primary outcome of drug-targeted MR analyses to test the relation between IL6R blockers and AS. Inverse variance weighting (IVW) is the primary analytical approach. Various sensitivity tests were performed to check the robustness and trustworthiness of the causality estimation, including consistency, heterogeneity, and pleiotropy analyses. In addition, repeated analysis was conducted using different GWAS data related to exposures and outcomes to examine the results for stability.ResultsAccording to the IVW results, IL6R inhibitors significantly reduced the risk of AS in ukb-b-18194 (OR: 0.995, 95% CI 0.993–0.996, P = 5.12 × 10−08) and ukb-a-88 (OR: 0.994, 95% CI 0.993–0.996, P = 6.25 × 10−15). Moreover, repeated analyses were performed using different exposure-related GWAS data, yielding similar results, ukb-b-18194 (OR: 0.995, 95% CI 0.993–0.997, P = 1.25 × 10−06) and ukb-a-88 (OR: 0.995, 95% CI 0.994–0.997, P = 7.81 × 10−09). Heterogeneity analyses and pleiotropy analyses indicated no significant heterogeneity or pleiotropy.ConclusionThis MR analysis result further validates that the IL-6 pathway may contribute to the pathogenesis of AS and that the inhibition of IL6R reduces the risk of AS. These findings may guide future studies and provide more favorable drug treatment options for people at high risk of AS.
Subpleural pulmonary nodule marking with patent blue V dye prior to surgical resection
Authors: Červeňák Vladimír , Chovanec Zdeněk , Berková Alena , Cimflová Petra , Kelblová Martina , Čundrle Ivan , Hanslík Tomáš , Resler Jan , Součková Lenka , Jankaničová Natália , Vaníček Jiří 
Published: May 2024

Background and objectiveSubpleural located pulmonary nodules are perioperatively invisible to the surgeon. Their precise identification is conventionally possible by palpation, but often at the cost of performing a thoracotomy. The aim of the study was to evaluate the success rate and feasibility of the pre-operative CT-guided marking subpleural localized nodule using a mixture of Patent Blue V and an iodine contrast agent prior to the extra-anatomical video-assisted thoracoscopic surgery (VATS) resection in patients for whom the primary anatomical resection in terms of segmentectomy or lobectomy was not indicated.MethodsThe data of consecutive patients with pulmonary nodules located ≤ 30 mm from the parietal pleura, who were indicated for VATS extra-anatomical resection between 2017 to 2023, were retrospectively reviewed and analyzed. All patients indicated for VATS resection underwent color marking of the area with the pulmonary lesion under CT-guided control immediately before the surgery. The primary outcome was the marking success. Morphological lesion characteristics, time from marking to the surgery, procedure related complications, final histology findings and 30day mortality were analyzed. Additionally, we assessed the association of the successful marking and the patient’s smoking history.ResultsA total of 62 lesions were marked. The successful marking was observed in 56/62 (90.3%) patients. The median time from the lesion marking to the beginning of surgery was 75.0 (IQR 65.0-85.0) minutes. The procedure related pneumothorax was observed in 6 (9.7%) patients, intraparenchymal hematoma in 1 (1.6%) patient. No statistically significant association of the depth of the subpleural lesion’s location, occurrence of complications or time from the marking to surgery and the successful marking was observed. The 30day mortality was zero. No association of smoking and successful marking was observed.ConclusionsThe method of marking the subpleural pulmonary lesions under CT-guided control with a mixture of Patent Blue V and iodine contrast agent is a safe and effective method with minimal complications. It provides surgeons the precise visualization of the affected pulmonary parenchyma before the planned extra-anatomical VATS resection.
Beyond words: an investigation of fine motor skills and the verbal communication spectrum in autism
Authors: Simarro Gonzalez Marian , Ni Gessica , Lam Valerie , Demopoulos Carly 
Published: May 2024

IntroductionThis study investigated the associations between fine motor skills and expressive verbal abilities in a group of 97 autistic participants (age 8-17, mean=12.41) and 46 typically developing youth (age 8-17, mean=12.48).MethodsParticipants completed assessments of motor and verbal communication skills, including finger tapping speed, grooved pegboard, grip strength, visual-motor integration tasks, and measures of speech and communication skills. ASD group performance on motor tests was compared to controls. Non-parametric tests were used to analyze group differences and correlations between motor and verbal communication skills. Based on prior research, we hypothesized that individuals on the autism spectrum would exhibit deficits in fine motor speed, dexterity, pencil motor control, but not manual motor strength. Additionally, we expected that impaired fine motor skills would be linked to poorer performance on standardized measures of verbal abilities.ResultsThe results indicated that 80% of autistic participants demonstrated an impairment on at least one measure of motor skills, and as a group, they exhibited significantly poorer fine motor performance compared to the non-ASD group in dominant hand finger tapping speed, bilateral fine motor dexterity measured via the grooved pegboard task, and pencil motor coordination and visual-motor integration measured on the Beery-Buktenica Developmental Test of Visual-Motor Integration-Sixth Edition. Moreover, impaired fine motor skills were associated with poorer performance on standardized clinical measures of verbal abilities, including articulation errors, receptive and expressive language and vocabulary, rapid naming, oromotor sequencing, and parent reported functional communication skills and social communication symptoms.DiscussionOverall,our findings suggest there is a high prevalence of fine motor impairments in ASD, and these impairments were associated with a range of verbal abilities. Further research is warranted to better understand the underlying mechanisms of these associations and develop targeted interventions to address both fine motor and verbal impairments in ASD.