bluuebunny/crossref_metadata_2025_split huggingface dataset:
Morphology of distal border synovial invaginations of the equine distal sesamoid bone
Authors: Bergman H. J. , van der Veen H. , Duchateau L. , Raes E. V. , Vanderperren K. , Saunders J. H. , Claerhoudt S. 
Published: July 2012

SummaryObjectives: To compare the difference and agreement of the morphology of distal border synovial invaginations on a dorsoproximal-palmarodistal oblique (DPr-PaDiO) projection with hoof-specific angle versus computed tomography.Methods: Computed tomography (CT) images and a DPr-PaDiO radiographic projection with hoof-specific angle were obtained on 50 cadaveric forefeet from 25 Warmblood horses. Computed tomography was assumed to be the gold standard. The number, shape and depth of penetration of distal border synovial invaginations into the distal sesamoid bone were evaluated with both methods, and the comparison of their measurements was statistically described.Results: Significantly more invaginations were seen on CT compared to radiography, with an observed average difference of 1.2. In none of the cases did radiography have a higher number than that observed with CT. No statistically significant difference for depth between CT and the DPr-PaDiO projection was seen, however, there was quite a large variation of the actual difference of measurements against their mean found. Radiography was underestimated when high mean values applied. The agreement between both modalities for shape was moderate to good. A very high specificity of the specific DPr-PaDiO projection for shape was found (97%).Clinical significance: The radiographic projection with hoof-specific angle differs significantly from CT concerning the number and depth of the distal border synovial invaginations. Therefore, this specific view may not be considered useful in the evaluation of these invaginations.
Development of 12 microsatellite markers for Platycrater arguta (Hydrangeaceae) endemic to East Asia
Authors: Qi Xin‐shuai , Yuan Na , Qiu Ying‐Xiong 
Published: July 2012

• Premise of the study: Microsatellite markers were characterized in Platycrater arguta, a rare endemic shrub from eastern China and southern Japan, to investigate its population genetic structure, phylogeographic patterns, and breeding system.• Methods and Results: Using both the Fast Isolation by AFLP of Sequences COntaining repeats (FIASCO) protocol and the compound microsatellite marker technique, we developed 12 microsatellite markers. All primers showed polymorphism when assessed in 43 individuals from two populations in eastern China and southern Japan. Overall, the number of alleles ranged from five to 21, with an average of 14.91 alleles per locus.• Conclusions: These markers can be used in further studies on population genetics, phylogeography, and breeding system of P. arguta.
Microsatellite markers for Saussurea gnaphalodes (Asteraceae), a native Himalayan mountain species
Authors: Zeng Liyan , Chong Lhag , Tersing Tashi , Bu Nor , Zhao Jiayuan , Zhong Yang 
Published: July 2012

• Premise of the study: Microsatellite markers were developed in Saussurea gnaphalodes to investigate its genetic variation and population structure.• Methods and Results: Using the combined biotin capture method, 46 microsatellite primer sets were isolated and characterized across 48 S. gnaphalodes individuals from three Tibetan populations. Seventeen of these markers showed polymorphism, and the number of alleles ranged from two to 17. The observed and expected heterozygosities per population ranged from 0 to 0.938 and from 0 to 0.905, respectively.• Conclusions: These markers provide a useful tool to investigate the genetic diversity and population structure of S. gnaphalodes, and to facilitate further studies on conservation and utilization.
Anonymous and EST‐based microsatellite DNA markers that transfer broadly across the fig tree genus (Ficus, Moraceae)
Authors: Heer Katrin , Machado Carlos A. , Himler Anna G. , Herre Edward Allen , Kalko Elisabeth K. V. , Dick Christopher W. 
Published: July 2012

• Premise of the study: We developed a set of microsatellite markers for broad utility across the species‐rich pantropical tree genus Ficus (fig trees). The markers were developed to study population structure, hybridization, and gene flow in neotropical species.• Methods and Results: We developed seven novel primer sets from expressed sequence tag (EST) libraries of F. citrifolia and F. popenoei (subgen. Urostigma sect. Americana) and optimized five previously developed anonymous loci for cross‐species amplification. The markers were successfully tested on four species from the basal subgenus Pharmacosycea sect. Pharmacosycea (F. insipida, F. maxima, F. tonduzii, and F. yoponensis) and seven species of the derived subgenus Urostigma (F. citrifolia, F. colubrinae, F. costaricana, F. nymphaeifolia, F. obtusifolia, F. pertusa, and F. popenoei). The 12 markers amplified consistently and displayed polymorphism in all the species.• Conclusions: This set of microsatellite markers is transferable across the phylogenetic breadth of Ficus, and should therefore be useful for studies of population structure and gene flow in approximately 750 fig species worldwide.
Development of microsatellite markers from Cercis chinensis (Fabaceae)
Authors: Gong Wei , Duan Tingting , Zhang Dianxiang 
Published: July 2012

• Premise of the study: Microsatellite markers were developed to characterize the level of genetic diversity and population genetic structure of Cercis chinensis, a widely cultivated garden plant in China with congeneric species disjunctly distributed in East Asia, North America, and the Mediterranean.• Methods and Results: Using the Fast Isolation by AFLP of Sequences COntaining repeats (FIASCO) protocol, eight microsatellite markers were developed in C. chinensis. Seven of the markers displayed polymorphism, with the number of alleles ranging from one to four in four populations of C. chinensis. Four to six microsatellite loci exhibited interspecific transferability in C. glabra, C. chuniana, and C. chingii.• Conclusions: These are the first microsatellite markers developed for C. chinensis, which will be further used in investigation of population genetic structure and phylogeographic pattern of C. chinensis and its congeneric species.
CD4+ T Cell-Dependent IFN-γ Production by CD8+ Effector T Cells inMycobacterium tuberculosisInfection
Authors: Bold Tyler D. , Ernst Joel D. 
Published: July 2012

AbstractBoth CD4+ and CD8+ T cells contribute to immunity to tuberculosis, and both can produce the essential effector cytokine IFN-γ. However, the precise role and relative contribution of each cell type to in vivo IFN-γ production are incompletely understood. To identify and quantitate the cells that produce IFN-γ at the site of Mycobacterium tuberculosis infection in mice, we used direct intracellular cytokine staining ex vivo without restimulation. We found that CD4+ and CD8+ cells were predominantly responsible for production of this cytokine in vivo, and we observed a remarkable linear correlation between the fraction of CD4+ cells and the fraction of CD8+ cells producing IFN-γ in the lungs. In the absence of CD4+ cells, a reduced fraction of CD8+ cells was actively producing IFN-γ in vivo, suggesting that CD4+ effector cells are continually required for optimal IFN-γ production by CD8+ effector cells. Accordingly, when infected mice were treated i.v. with an MHC-II–restricted M. tuberculosis epitope peptide to stimulate CD4+ cells in vivo, we observed rapid activation of both CD4+ and CD8+ cells in the lungs. Indirect activation of CD8+ cells was dependent on the presence of CD4+ cells but independent of IFN-γ responsiveness of the CD8+ cells. These data provide evidence that CD4+ cell deficiency impairs IFN-γ production by CD8+ effector cells and that ongoing cross-talk between distinct effector T cell types in the lungs may contribute to a protective immune response against M. tuberculosis. Conversely, defects in these interactions may contribute to susceptibility to tuberculosis and other infections.
Trisomy 21, a consequence of advanced maternal age
Authors: Osati Elisha Otieno 
Published: July 2012

K.M, a 1 year and 9 month old male child from Mwanza was referred from Bugando Hospital to Muhimbili National hospital for further investigations and management. He presented with gradual onset of dry recurrent cough and difficulty in breathing for 20 months and low grade recurrent fever for 9 months. His mother was 43 years and father 45 years old. On examination he was alert, febrile (38.5oC), acyanotic, with up-slanting eyes, low set ears, flat nose-bridge, small chin, short neck, pigeon chest and webbed toes. He was malnourished with delayed developmental milestones. A pansystolic murmur was auscultated at the lower left sternal edge; and he had impaired speech, reduced muscle bulk and muscle tone with muscle power of grade 3.
The Effect of Material Modeling on Finite Element Analysis of Human Breast Biomechanics
Authors: Ruggiero Leonardo , Sol Hugo , Sahli Hichem , Adriaenssens Sigrid , Adriaenssens Nele 
Published: July 2012

Purpose Finite element analysis has been used extensively in the study of biomechanical modeling of the breast. However, issues regarding the complexity of material models and the influences of geometric boundary conditions on the accuracy of a breast Finite Element (FE) model are still under debate. This work demonstrates the importance of material modeling in FE models of the breast. Methods A simple hemispherical geometry is used to model the shape of a human breast. Different material models are being investigated to accurately model changes in terms of displacement, stress, and reaction forces distribution. Results The results obtained using nonlinear material models are compared with those obtained employing their linear approximation. Results have shown that differences, in terms of displacement, ranging between 20% and more than 80%, may occur and that large differences are present in terms of maximum principal stresses when the displacement is correctly approximated. Conclusions This study clearly shows that, in a FE model, simulating large deformations material modeling strongly influences the accuracy of the solution.
Arteriovenous Fistula Failure: Is There a Role for Accessory Draining Vein Embolization?
Authors: Nikam Milind , Popuri Radha K. , Inaba Akimichi , Taylor Usamah , Farquharson Finn , Mitra Sandip , Chalmers Nicholas 
Published: July 2012

Purpose Arterio-venous fistulae (AVFs) are accepted as the best form of haemodialysis vascular access (VA) but are plagued by high primary failure. Accessory drainage veins (ADVs) may account for up to 40% of these failures. Furthermore, they may also lead to low flow in ‘mature’ AVFs. Methods We analysed the results of 42 patients who underwent endovascular coiling of ADVs at our centre over a 4-year period. Results Indications were failure to mature in 34%, low flow or cannulation difficulty in 56% and thrombosis in 10% of cases. 95% procedures involved a combination of angioplasty and coiling with only 5% patients having coiling of ADV alone. Forearm AVFs constituted the majority of the cases as opposed to upper arm AVFs (74% vs. 26% respectively). Primary patency at 3, 6, 12, 18 and 24 months was 90%, 87%, 76%, 70% and 55% respectively. Successful dialysis was achieved in 10 of the 14 fistulae that had hitherto failed to mature. Coil migration was observed in 1 patient, which led to fistula occlusion. Conclusion Coil embolisation of ADVs is an effective treatment option for dysfunctional fistulae that can be performed at the same time as angioplasty.
Global Business Ethics: Regulation, Code, or Self-Restraint
Authors: Cavanagh Gerald F. 
Published: July 2012

Abstract:Three strategies for developing just and consistent global business practices are examined: 1) international treaties and agreements, 2) global codes of business conduct, and 3) voluntary self-restraint. International agreements investigated are: NAFTA, Global Warming Treaty, OECD Anti-Bribery Treaty and Infant Formula Agreement. The codes examined are the Caux Round Table’sPrinciples for Business, The Global Sullivan Principlesand The United NationsGlobal Compact with Business. Each of these three strategies is probed for its relative strengths and weaknesses, and its prospects for developing ethical business practices—especially in the areas of improving the environment, human rights and working conditions.
The Obligations of Transnational Corporations: Rawlsian Justice and the Duty of Assistance
Authors: Hsieh Nien-hê 
Published: July 2012

Abstract:Building on John Rawls’s account of the Law of Peoples, this paper examines the grounds and scope of the obligations of transnational corporations (TNCs) that are owned by members of developed economies and operate in developing economies. The paper advances two broad claims. First, the paper argues that there are conditions under which TNCs have obligations to fulfill a limited duty of assistance toward those living in developing economies, even though the duty is normally understood to fall on the governments of developed economies. Second, by extending Rawls’s account to include a right to protection against arbitrary interference, the paper argues that TNCs can be said to have negative and positive obligations in the areas of human rights, labor standards, and environmental protection, as outlined in the U.N. Global Compact. More generally, the paper aims to further our understanding of the implications of Rawls’s account of justice.
Spirituality and Archetype in Organizational Life
Authors: Hart David W. , Neil Brady F. 
Published: July 2012

Abstract:Spirituality is an undeniable human need and is thus the subject of increasing interest among management scholars and practitioners. In this article, we propose using archetypal psychology as a framework for understanding the human need for spirituality more clearly because it provides important insights into spirituality and organizational life. Because most spiritual needs reside in the deepest aspects of the self, an archetypal approach helps us recognize not only that we have spiritual needs but alsowhywe have them. We present three common archetypes and their implications in a management context. That is followed by an application of the archetypal approach to some of the more spiritually corrosive aspects of organizational life and a discussion of the implications of archetypes as a source of motivation.
Distributive Justice and the Rules of the Corporation: Partial Versus General Equilibrium Analysis
Authors: Beck John H. 
Published: July 2012

Abstract:Progressives have advocated reforms of rules governing corporations to achieve greater distributive justice, but Maitland (2001) has argued that corporate rules are distributively neutral and that changing the rules will have no long run impact on distributive justice. These different conclusions stem from the use of two different methods of economic analysis, partial equilibrium and general equilibrium models. A change in the rules governing corporations in a “large” sector of the economy is appropriately analyzed using a general equilibrium analysis, supporting the conclusion that changes in the rules may affect distributive justice in the long run. However, a partial equilibrium analysis of a change in the rules of corporations affecting a “small” part of the economy such as a single firm or even all firms in a small state supports the claim that such changes cannot affect distributive justice.
Can Corporations be Citizens? Corporate Citizenship as a Metaphor for Business Participation in Society
Authors: Moon Jeremy , Crane Andrew , Matten Dirk 
Published: July 2012

Abstract:This paper investigates whether, in theoretical terms, corporations can be citizens. The argument is based on the observation that the debate on “corporate citizenship” (CC) has only paid limited attention to the actual notion of citizenship. Where it has been discussed, authors have either largely left the concept of CC unquestioned, or applied rather unidimensional and decontextualized notions of citizenship to the corporate sphere. The paper opens with a critical discussion of a major contribution to the CC literature, the work of Logsdon and Wood (Wood and Logsdon 2001; Logsdon and Wood 2002). It continues with a consideration of the nature and role of metaphors for business and of the contestable nature of the political concept of citizenship. It evaluates corporations as citizens through a four-dimensional framework of democratic citizenship offered by Stokes (2002). The analysis suggests that corporations do not easily fit the “liberal minimalist” model of citizenship. It finds, however some possibilities for fit with the three more participatory models. The paper concludes by cautioning against basing corporate citizenship on legal and administrative status or identity, and mapping out specific criteria by which we might determine whether corporations could be considered as citizens by virtue of their participation in processes of governance.
Business Ethics and Internal Social Criticism
Authors: Sonenshein Scott 
Published: July 2012

Abstract:The purpose of this paper is to present an understanding of business ethics based on a theory of internal social criticism. Internal social criticism focuses on how members of a business organization debate the meanings of their shared traditions for the purpose of locating and correcting hypocrisy. Organizations have thick moral cultures that allow them to be self-governing moral communities. By considering organizations as interpretive moral communities, I challenge the conventional notion that moral criticism is based primarily on exogenous moral principles delivered by outside critics. I describe an interpretive process of business ethics and develop a theoretical model of internal social criticism. I also propose that organizational identification serves as a mechanism for inducing ethical behavior. I conclude by calling for more research that understands the development and use of existing moral principles inside of organizations.
The Corporate Social Responsibility of the Pharmaceutical Industry: Idealism without Illusion and Realism without Resignation
Authors: Leisinger Klaus M. 
Published: July 2012

Abstract:In recent years society has come to expect more from the “socially-responsible” company and the global HIV/AIDS pandemic in particular has resulted in some critics saying that the “Big Pharma” companies have not been living up to their social responsibilities. Corporate social responsibility can be understood as the socio-economic product of the organizational division of labor in complex modern society. Global poverty and poor health conditions are in the main the responsibilities of the world’s national governments and international governmental organizations, which possess society’s mandate and appropriate organizational capabilities. Private enterprises have neither the societal mandate nor the organizational capabilities to feed the poor or provide health care to the sick in their home countries or in the developing world. Nevertheless, private enterprises do have responsibilities to society that can be categorized as what they must do, what they ought do, and what they can do.
Child Workers, Globalization, and International Business Ethics: A Case Study in Brazil’s Export-Oriented Shoe Industry
Authors: French J. Lawrence , Wokutch Richard E. 
Published: July 2012

Abstract:Disputes regarding the ethics of work by children have intensified in recent years, with little resolution. The impasses stem from failure to recognize the diverse forms of child work and a lack of empirical research regarding its causes and consequences. We report on data gathered in Brazil’s export-oriented shoe industry, which is notorious for the employment of children. Central findings are: 1) the causes of child work have less to do with backwardness and more to do with how shoe workers are integrated into the global order; 2) local employers and children regard this work as benign, but the U.S. government sees it as hazardous to children and unfair to U.S. producers; 3) efforts to remove children from the shoe industry have been frustrated by local resistance and raise ethical questions; and 4) in certain circumstances, efforts to eliminate hazards from the workplace are morally superior to campaigns to remove child workers from employment.
Ethical Investing: Ethical Investors and Managers
Authors: Hudson Richard 
Published: July 2012

Abstract:“Ethical investing” is interpreted in the following paper to be the use of non-financial normative criteria by investors in the choice of securities for their portfolios.Ethical investors may aim at fulfilling duties they feel they have, possibly including increasing the amount of good in society through the consequences of their buying and selling behavior. The main duties are those of not-profiting from bad corporate behavior and of punishing bad (or rewarding good) firms. The main consequence desired is that managers manage corporations in a more ethical manner. But ethical investors (as opposed to some other kinds of investors who are also interested in normative issues) also aim at receiving returns based on the market risk of their investments.If the aim of managers is to maximize shareholder wealth, then ethical investors can fulfill their duties or achieve their desired consequences only if their trading activities affect shareholder wealth, i.e., share price. A theoretical argument is presented to show that this trading activity will not affect share price or return. In addition, reference is made to results of empirical studies which show that ethical stocks yield market returns, i.e., that the share price of ethical firms is unaffected by the actions of ethical investors.If the trading activity of ethical investors fails to affect share price and return, then these investors fail to fulfill any of their goals or to achieve their ends.
An Employee-Centered Model of Corporate Social Performance
Authors: Van Buren III Harry J. 
Published: July 2012

Abstract:Although the concept of corporate social performance (CSP) has become more clearly specified in recent years, an analysis of CSP from the perspective of one particular stakeholder group has been largely ignored in this research: employees. It is proposed that employees merit specific attention with regard to assessments of corporate social performance. In this paper, a model for evaluating and measuring CSP at the employee level is proposed, and implications for evaluating contemporary employment policies and practices are offered. An iterative process for systematically including normative content in the CSP model across stakeholder groups is also offered.
Moral Commitments and the Societal Role of Business: An Ordonomic Approach to Corporate Citizenship
Authors: Pies Ingo , Hielscher Stefan , Beckmann Markus 
Published: July 2012

ABSTRACTThis article introduces an “ordonomic” approach to corporate citizenship. We believe that ordonomics offers a conceptual framework for analyzing both the social structure and the semantics of moral commitments. We claim that such an analysis can provide theoretical guidance for the changing role of business in society, especially in regard to the expectation and trend that businesses take a political role and act as corporate citizens. The systematicraison d'êtreof corporate citizenship is that business firms can and—judged by the criterion of prudent self-interest—“should” take on an active role in rule-finding discourses and rule-setting processes with the intent of realizing a win-win outcome of the economic game. We identify—and illustrate—four ways that corporate citizens can employ moral commitments as a factor of production to enhance their processes of economic value creation.