bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ultrahigh Sensitivity for Thermographic Human–Machine Interface via Precious Metals Atomic Layer Deposition on V‐MXene: Computational and Experimental Exploration
Authors: Mohapatra Debananda , Kang Hyun Jin , Lee Sanghyuk , Son Yeseul , Ansari Mohd Zahid , Kang Youngho , Lee Jung Woo , Kim Soo‐Hyun 
Published: June 2024

AbstractGlobal healthcare based on the Internet of Things system is rapidly transforming to measure precise physiological body parameters without visiting hospitals at remote patients and associated symptoms monitoring. 2D materials and the prevailing mood of current ever‐expanding MXene‐based sensing devices motivate to introduce first the novel iridium (Ir) precious metal incorporated vanadium (V)‐MXene via industrially favored emerging atomic layer deposition (ALD) techniques. The current work contributes a precise control and delicate balance of Ir single atomic forms or clusters on the V‐MXene to constitute a unique precious metal‐MXene embedded heterostructure (Ir‐ALD@V‐MXene) in practical real‐time sensing healthcare applications to thermography with human–machine interface for the first time. Ir‐ALD@V‐MXene delivers an ultrahigh durability and sensing performance of 2.4% °C−1 than pristine V‐MXene (0.42% °C−1), outperforming several conventionally used MXenes, graphene, underscoring the importance of the Ir‐ALD innovative process. Aberration‐corrected advanced ultra‐high‐resolution transmission/scanning transmission electron microscopy confirms the presence of Ir atomic clusters on well‐aligned 2D‐layered V‐MXene structure and their advanced heterostructure formation (Ir‐ALD@V‐MXene), enhanced sensing mechanism is investigated using density functional theory (DFT) computations. A rational design empowering the Ir‐ALD process on least explored V‐MXene can potentially unfold further precious metals ALD‐process developments for next‐generation wearable personal healthcare devices.
Zinc‐Based ROS Amplifiers Trigger Cancer Chemodynamic/Ion Interference Therapy Through Self‐Cascade Catalysis
Authors: Sun Yun , Qin Liting , Yang Yuhan , Gao Jingzhe , Zhang Yudi , Wang Hongyu , Wu Qingyuan , Xu Bolong , Liu Huiyu 
Published: June 2024

AbstractNanozyme‐mediated chemodynamic therapy has emerged as a promising strategy due to its tumor specificity and controlled catalytic activity. However, the poor efficacy caused by low hydrogen peroxide (H2O2) levels in the tumor microenvironment (TME) poses challenges. Herein, an H2O2 self‐supplying nanozyme is constructed through loading peroxide‐like active platinum nanoparticles (Pt NPs) on zinc peroxide (ZnO2) (denoted as ZnO2@Pt). ZnO2 releases H2O2 in response to the acidic TME. Pt NPs catalyze the hydroxyl radical generation from H2O2 while reducing the mitigation of oxidative stress by glutathione, serving as a reactive oxygen (ROS) amplifier through self‐cascade catalysis. In addition, Zn2+ released from ZnO2 interferes with tumor cell energy supply and metabolism, enabling ion interference therapy to synergize with chemodynamic therapy. In vitro studies demonstrate that ZnO2@Pt induces cellular oxidative stress injury through enhanced ROS generation and Zn2+ release, downregulating ATP and NAD+ levels. In vivo assessment of anticancer effects showed that ZnO2@Pt could generate ROS at tumor sites to induce apoptosis and downregulate energy supply pathways associated with glycolysis, resulting in an 89.7% reduction in tumor cell growth. This study presents a TME‐responsive nanozyme capable of H2O2 self‐supply and ion interference therapy, providing a paradigm for tumor‐specific nanozyme design.
Helical Ni‐Cluster Organic Framework Constructed from Enantiopure Lactate Derivative: Synthesis, Structure and Properties
Authors: Xu Zhong‐Xuan , Ying Xiu‐Ju , Fei Fei 
Published: June 2024

AbstractUnder hydrothermal condition, lactate derivative (R)‐4‐(1‐ carboxyethoxy)‐2‐methylbenzoic acid ((R)‐H2cma) as chiral synthon assembled with 4,4′‐di(1H‐imidazol‐1‐yl)‐1,1′‐biphenyl (4,4’‐dib) and Ni(II) ions to obtain complex {[Ni2((R)‐cma)2(4,4’‐dib)2(H2O)] ⋅ 2H2O}n (HU20‐R). In complex HU20‐R, carboxyl group from lactate unit of (R)‐cma2− anion and coordinating H2O molecule adopt a μ2‐coordination mode to obtain dinuclear [Ni2(CO2)2(H2O)]2+ cluster. (R)‐cma2− anions and Ni(II) ions build single left‐handed (R)‐cma‐Ni‐chain, while 4,4’‐dib ligands are bridged by different Ni(II) centers to form double left‐handed 4,4’‐dib‐Ni‐chain. These helical secondary structures are further connected together to result in an 8‐connected 3D framework. PXRD tests indicated that complex HU20‐R has well hydro‐stability. UV‐vis absorption experiment confirmed that HU20‐R is a semi‐conducting material with strong absorption capacity for ultraviolet‐visible (UV‐vis) light. Additionally, electrochemical experiment revealed that HU20‐R has low impedance and high charge transport capacity. Further test results confirm that HU20‐R has noticeable photo‐catalytic effect in photodegradation of Rhodamine B (RhB) and antiferromagnetic property.
Istanbul as the Symbolic Space of the Neo-Ottomanist Narrative: Nostalgia, Romanticism and Domestic Imperial Greed
Authors: Tokdoğan Nagehan 
Published: June 2024

AbstractThis chapter focuses on the symbolic and emotional manifestations of Neo-Ottomanist narratives on space. As one of the leading symbols of Neo-Ottomanism, Istanbul has always had a significant value for the Islamic conservative tradition and has been instrumentalized as a site of emotional and financial investment under AKP rule. The Islamic dream of reconquering the city has been realised through interventions in the abstract and concrete textures of the city. In this chapter I analyse the AKP’s symbolic reconquest of Istanbul, which mainly derived from ontological ressentiment, urge for revenge, nostalgia, romanticism and imperial greed.
Towards the Construction of a Neo-Ottomanist Myth: The ‘Legend’ of 15 July and National Narcissism
Authors: Tokdoğan Nagehan 
Published: June 2024

AbstractThe coup attempt of 15 July 2016 was another turning point in the emotional climate of Turkey, characterized by the victimhood claim of the Islamic conservatives, from which the AKP arose. It transformed a historical narrative, largely dominated by defeat and suppression, into a completely different narrative of the present, one characterized by triumph and self-worship. This chapter focuses on the AKP’s efforts to create a national myth through the 15 July incident, and discusses whether these efforts have been successful drawing on the notions of ‘national narcissism’ and ‘collective narcissism’.
Positioning Rural Geography into Platform Economies: Why We Need to Ask New Questions When Researching the Rural Platform Economy
Authors: Zhang Qian , Webster Natasha A. 
Published: June 2024

AbstractA rapidly growing body of work explores platform-mediated economy and work under the umbrella term ‘Platform Urbanism’. This focus and academic discourse risk keeping digital spaces and practices in the rural context in the shadow or subordinated to urban-based understandings. Concurrently, digital studies on the rural have for long focused on technocratic approaches to improving information and communications technology (ICT) infrastructure and connectivity. While recently the potentials of digitalization in transforming agriculture, small businesses, health care, and transportation in rural areas are receiving significant attention, these debates remain surprisingly disconnected from vibrant discussions of the platform economy. Thus, the remaking of rural geographies through the platform economy, and vice versa, remains under-examined. This chapter addresses the importance of spatiality and geography in considering the platform economy with examples of rural small business and agriculture. It illustrates why the nuances and complexity of rural spaces need to become part of understanding the dynamics of the platform economy. Centring rural as important and spatially significant not only lifts the complexity of rural platform processes but also creates opportunities for new questions and patterns. Rural geographical perspectives highlight relational and interlocking spaces found in the rural platform economy and offer the potential for a deeper understanding of social-technical-spatial relations.
Making Sense of Marine-Based Search and Rescue Response Time Using Network Analysis
Authors: Stoddard Mark A. , Pelot Ronald , Goerlandt Floris , Etienne Laurent 
Published: June 2024

AbstractNavigation in polar waters follows standard navigational practice, with special consideration for the presence of sea ice and its expected impact on safe ship operation. Experienced polar ship operators rely on timely access to authoritative sea ice analysis and knowledge of the safe operational limits of their ship to determine the navigability of polar waters. Several sea ice risk assessment frameworks exist to assist ship operators with onboard decision-making, most notably, the Polar Operational Limit Assessment Risk Indexing System (POLARIS). The result from POLARIS is referred to as the Risk Index Outcome (RIO). By adjusting ship speed in response to the RIO value, it is possible to account for sea ice risk in the estimation of ship transit time in polar waters. In this chapter we discuss the use of network analysis techniques to generate the fastest route between two locations in the Arctic and to compute surface ship incident response service areas (IRSA) and incident response isochrones (IRI) for different times of year and ship ice classes. The use of IRSA and IRI to support area-based management (ABM) tools that aim to formally incorporate historical observations of shipping activity into quantitative assessments is also discussed. Incorporating IRSA and IRI results into ABM tools would provide decision-makers with a useful tool to possibly help plan and coordinate incident response in polar waters and support ABM of commercial vessel operation and search and rescue provision.
Conclusion
Authors: Pelot Ronald , Chircop Aldo , Goerlandt Floris , Aporta Claudio 
Published: June 2024

AbstractThis concluding chapter serves to elaborate and extrapolate some of the main points delivered throughout this book’s collection of complementary perspectives on area-based management (ABM) applied to maritime shipping. Researchers and practitioners in this continuously developing field of ABM can benefit from the diverse perspectives provided in this text, which are synthesized according to key facets, namely, the purpose of ABM and basic principles that mould its construction and application; the role of risk governance and risk analysis in shaping ABM applications and for determining how shipping-related risks may thus be mitigated; how marine spatial planning (MSP), another rapidly growing tool that systematically advances sustainable management of marine areas, intersects with the suite of ABM tools; and what comprises good practices when implementing ABM processes and tools. The chapter concludes with some remarks on fruitful areas for additional research that may further strengthen ABM.
Vessel Traffic Management in the Era of Maritime Autonomous Surface Ships and Digitalization: Experiences in European Waters
Authors: Hebbar Anish Arvind , Schröder-Hinrichs Jens-Uwe , Yildiz Serdar 
Published: June 2024

AbstractThe safety of navigation in approaches to harbours and along coasts has been a concern since the beginning of maritime trade approximately 2000 years ago. The ways and means for facilitating the safety and efficiency of maritime navigation have undergone a remarkable transformation from lighthouses, first established in 300–280 BC in Alexandria, Egypt, combined with the use of flag signals by ships to announce their arrival when approaching a harbour, through the use of radars for electronic monitoring combined with radio communications by ships, to the use of satellite-based automatic identification systems combined with automated digital information exchange between maritime autonomous surface ships and geographically distant shore control centres.This chapter examines vessel traffic management from an interwoven, regulatory, and technological perspective. It attempts to trace the evolution of international and European Union regulatory and organizational frameworks in response to the emerging needs of navigational safety and efficiency. In this context, essential technical jargon as key to an understanding of the topic of vessel traffic management is unpacked. Relevant work of the International Maritime Organization, International Association of Marine Aids to Navigation and Lighthouse Authorities, European Commission, and European Maritime Safety Agency (EMSA) is discussed. The transformative role of the European Maritime Single Window environment stands out while traversing the contribution of technological advancements in the maritime domain leading to the development of vessel traffic management system architecture and capabilities. Digitalization and automation in maritime infrastructure are explored for their influence and significance of contribution to navigational safety. The ensuing discussion highlights the role of maritime single windows and the EMSA’s SafeSeaNet as key pillars for enhanced situational awareness in European waters together with the cutting-edge approach of sea traffic management. The chapter concludes with a fascinating outlook on the vessel traffic management system of the future in the emerging context of the fourth industrial revolution driven by artificial intelligence, machine learning, and maritime autonomous surface ships.
Revealing molecular determinants governing mambalgin-3 pharmacology at acid-sensing ion channel 1 variants
Authors: Cristofori-Armstrong Ben , Budusan Elena , Smith Jennifer J. , Reynaud Steve , Voll Kerstin , Chassagnon Irène R. , Durek Thomas , Rash Lachlan D. 
Published: June 2024

AbstractAcid-sensing ion channels (ASICs) are trimeric proton-gated cation channels that play a role in neurotransmission and pain sensation. The snake venom-derived peptides, mambalgins, exhibit potent analgesic effects in rodents by inhibiting central ASIC1a and peripheral ASIC1b. Despite their distinct species- and subtype-dependent pharmacology, previous structure-function studies have focussed on the mambalgin interaction with ASIC1a. Currently, the specific channel residues responsible for this pharmacological profile, and the mambalgin pharmacophore at ASIC1b remain unknown. Here we identify non-conserved residues at the ASIC1 subunit interface that drive differences in the mambalgin pharmacology from rat ASIC1a to ASIC1b, some of which likely do not make peptide binding interactions. Additionally, an amino acid variation below the core binding site explains potency differences between rat and human ASIC1. Two regions within the palm domain, which contribute to subtype-dependent effects for mambalgins, play key roles in ASIC gating, consistent with subtype-specific differences in the peptides mechanism. Lastly, there is a shared primary mambalgin pharmacophore for ASIC1a and ASIC1b activity, with certain peripheral peptide residues showing variant-specific significance for potency. Through our broad mutagenesis studies across various species and subtype variants, we gain a more comprehensive understanding of the pharmacophore and the intricate molecular interactions that underlie ligand specificity. These insights pave the way for the development of more potent and targeted peptide analogues required to advance our understating of human ASIC1 function and its role in disease.
On the infiltration of cellular solids by sheet molding compound: process simulation and experimental validation
Authors: Bernardi Federico , Sensini Alberto , Raimondi Luca , Donati Lorenzo 
Published: June 2024

AbstractThis study examines a numerical method to simulate the production of novel multi-material metal-composite components, where an additive-manufactured cellular solid is infiltrated by a sheet molding compound (SMC) in a single-step compression molding operation. A single-fiber numerical approach is adopted to predict microstructural changes, such as fiber orientation, fiber-matrix separation, and fiber volume content variations during molding. The accuracy of the numerical predictions is confirmed by physical samples using micro-computed tomography and optical microscopy investigations at both the qualitative and quantitative scales. From optical microscopy observations, there emerged a positive correlation between experimental outcomes and simulation results, accurately capturing fiber swirling, wrinkling, and draping that occurred during molding. At a quantitative scale, a 0.6% mismatch was observed when void volume and unfilled areas were compared, as measured by micro-computed tomography and numerical simulation.
In silico prediction of the interaction of legacy and novel per- and poly-fluoroalkyl substances (PFAS) with selected human transporters and of their possible accumulation in the human body
Authors: Tiburtini G. A. , Bertarini L. , Bersani M. , Dragani T. A. , Rolando B. , Binello A. , Barge A. , Spyrakis F. 
Published: June 2024

AbstractPer- and poly-fluorinated compounds constitute a wide group of fluorocarbon chemicals with widespread industrial applications, ranging from non-stick coating in cookware to water surfactants, from fire-fighting foams to water-repellent coatings on textiles. Presently, over 12,000 PFAS are known worldwide. In recent years, extensive research has focused on investigating the biological effects of these molecules on various organisms, including humans. Here, we conducted in silico simulations to examine the potential binding of a representative selection of PFAS to various human proteins known to be involved in chemical transportation and accumulation processes. Specifically, we targeted human serum albumin (HSA), transthyretin (TTR), thyroxine binding protein (TBG), fatty acid binding proteins (FABPs), organic anion transporters (OATs), aiming to assess the potential for bioaccumulation. Molecular docking simulations were employed for this purpose, supplemented by molecular dynamics (MD) simulations to account for protein flexibility, when necessary. Our findings indicate that so-called “legacy PFAS” such as PFOA or PFOS exhibit a higher propensity for interaction with the analysed human protein targets compared to newly formulated PFAS, characterised by higher branching and hydrophilicity, and possibly a higher accumulation in the human body.
Gemcitabine-loaded chitosan nanoparticles enhanced apoptotic and ferroptotic response of gemcitabine treatment alone in the pancreatic cancer cells in vitro
Authors: Aydemir Duygu , Öztürk Kıvılcım , Arslan Fatma Betül , Çalis Sema , Ulusu Nuriye Nuray 
Published: June 2024

AbstractGemcitabine (GEM) is a first-line treatment for pancreatic ductal adenocarcinoma (PDAC) patients, causing side effects and poor overall survival. Eighty percent of patients often develop resistance rapidly to GEM. Developing therapeutic approaches and increasing sensitivity to gemcitabine in PDAC has become one of the challenges in cancer research. We synthesized GEM-loaded NPs prepared with a method that combines ultrasonication and ionotropic gelation to overcome GEM-related limitations in PDAC. CFPAC-1 cells were treated with increased concentrations of GEM, empty chitosan, and GEM-loaded NPs (0.66, 1.32, 2.64, 5.32 µg/ml) for up to 48 h. Empty chitosan NPs did not show toxicity on L929 cells. Antioxidant enzyme activities, including glucose 6-phosphate dehydrogenase (G6PD), 6-phosphogluconate dehydrogenase (6-PGD), glutathione reductase (GR), glutathione s-transferase (GST), and glutathione peroxidase (GPx), significantly reduced in GEM-loaded NPs compared to the GEM associated with increased oxidative stress, PPP, and glycolysis. Bcl-xL, NOXA/mcl-1, and Ca2+ levels significantly increased in GEM-loaded NP-administered cells compared to the GEM and control groups. In contrast, JNK, p38, STAT3, Akt, and CREB levels significantly decreased in the GEM-loaded NP group, addressing enhanced apoptotic response compared to the GEM alone. Increased ferroptosis activity in GEM-loaded NP-administered groups has been validated via decreased antioxidant enzyme activities, increased cytosolic Fe, Zn, Mg, and Mn levels, and reduced GPx activity compared to the GEM and control groups. For the first time in the literature, we showed biocompatible GEM-loaded NPs enhanced apoptotic and ferroptotic response in CFPAC-1 cells via downregulation of antioxidant, glycolysis, and PPP metabolism compared to the GEM alone.
Graphical abstract
$$H(\textrm{div})$$-conforming HDG methods for the stress-velocity formulation of the Stokes equations and the Navier–Stokes equations
Authors: Qiu Weifeng , Zhao Lina 
Published: June 2024

AbstractIn this paper we devise and analyze a pressure-robust and superconvergent HDG method in stress-velocity formulation for the Stokes equations and the Navier–Stokes equations with strongly symmetric stress. The stress and velocity are approximated using piecewise polynomial space of order k and $$H(\textrm{div};\Omega )$$

H
(
div
;
Ω
)

-conforming space of order $$k+1$$

k
+
1

, respectively, where k is the polynomial order. In contrast, the tangential trace of the velocity is approximated using piecewise polynomials of order k. Moreover, the characterization of the proposed schemes shows that the globally coupled unknowns are the normal trace and the tangential trace of velocity, and the piecewise constant approximation for the trace of the stress. The discrete $$H^1$$

H
1

-stability is established for the discrete solution. The proposed formulation yields divergence-free velocity, but causes difficulties for the derivation of the pressure-independent error estimate given that the pressure variable is not employed explicitly in the discrete formulation. This difficulty can be overcome by observing that the $$L^2$$

L
2

projection to the stress space has a nice commuting property. Moreover, superconvergence for velocity in discrete $$H^1$$

H
1

-norm is obtained, with regard to the degrees of freedom of the globally coupled unknowns. Then the convergence of the discrete solution to the weak solution for the Navier–Stokes equations via the compactness argument is rigorously analyzed under minimal regularity assumption. The strong convergence for velocity and stress is proved. Importantly, the strong convergence for velocity in discrete $$H^1$$

H
1

-norm is achieved. Several numerical experiments are carried out to confirm the proposed theories.
From plactic monoids to hypoplactic monoids
Authors: Guilherme Ricardo P. 
Published: June 2024

AbstractThe plactic monoids can be obtained from the tensor product of crystals. Similarly, the hypoplactic monoids can be obtained from the quasi-tensor product of quasi-crystals. In this paper, we present a unified approach to these constructions by expressing them in the context of quasi-crystals. We provide a sufficient condition to obtain a quasi-crystal monoid for the quasi-tensor product from a quasi-crystal monoid for the tensor product. We also establish a sufficient condition for a hypoplactic monoid to be a quotient of the plactic monoid associated to the same seminormal quasi-crystal.