bluuebunny/crossref_metadata_2025_split huggingface dataset:
Vocal process granuloma and glottal insufficiency: An overlooked etiology?
Authors: Carroll Thomas L. , Gartner‐Schmidt Jackie , Statham Melissa M. , Rosen Clark A. 
Published: October 2009

AbstractObjectives/Hypothesis:Vocal process granuloma has been attributed to intubation, laryngopharyngeal reflux, and phonotraumatic/hyperfunctional vocal behaviors. Vocal process granuloma has recurrence rates following surgical excision approaching 92%. We hypothesize that a portion of persistent or idiopathic cases of vocal process granuloma result from underlying glottal insufficiency (GI) caused by paresis, scar, or atrophy. Our goal was to examine our vocal process granuloma population and determine the incidence of GI, treatment interventions, and outcomes.Study Design:Retrospective chart review.Methods:Thirty‐four patients with vocal process granuloma were divided into surgically or conservatively managed groups. Patients were identified if they carried a diagnosis of GI. The time to resolution and number of recurrences within the overall treatment period was recorded and compared between subgroups. Pre‐ and post‐treatment Voice Handicap Index‐10 (VHI‐10) and Reflux Symptom Index (RSI) scores were compared.Results:Eighteen of 34 patients (53%) carried an underlying diagnosis of GI, 13/34 (38%) were treated surgically, and 8/13 (62%) surgical patients had underlying GI. VHI‐10 and RSI scores significantly improved after disease resolution (P < .05).Conclusions:The incidence of GI among patients with vocal process granuloma was 53%. Conservative therapies including treatment of laryngopharyngeal reflux and voice therapy may lead to resolution despite underlying glottal incompetence. If conservative measures fail, recognizing and treating glottal incompetence with true vocal fold augmentation may lead to a shorter surgical treatment course. Laryngoscope, 2010
Patient reported voice outcome in recurrent respiratory papillomatosis
Authors: van Nieuwenhuizen Annette J. , Rinkel Rico N. P. M. , de Bree Remco , Leemans C. René , Verdonck‐de Leeuw Irma M. 
Published: October 2009

AbstractObjectives/Hypothesis:To assess the impact of patient reported voice outcome on quality of life and emotional functioning in patients treated for recurrent respiratory papillomatosis (RRP).Study Design:Cross‐sectional.Methods:All adult patients treated for RRP between 1984 and 2008 were asked to participate. Outcome measures were obtained from questionnaires including VHI (Voice Handicap Index), HADS (Hospital Anxiety and Depression Scale), 36‐Item Short Form Health Survey (SF‐36), and Utrechtse Coping List.Results:Out of 45 included patients, 34 (22 males,12 females) participated (76%). Mean age was 52 years (range, 25–85 years). RRP was located only in the larynx in 90% of the cases. Adult onset RRP was diagnosed in 29 cases, juvenile onset RRP in 5. Median number of surgical procedures was five (range, 1–17). In this study cohort, 68% scored above the VHI cutoff point, and 18% had an increased risk for depression or anxiety disorders (HADS). VHI scores were related to age, time between consecutive surgeries, time since last surgery, and passive coping. They were not related to gender, onset of RRP, or location. VHI scores were related to the SF‐36 subscales social functioning (r = −0.43) and mental health (r = −0.43).Conclusions:Patients with RRP often report voice problems in daily life, and this is related to (a passive) coping style, social functioning, and mental health. Psychosocial intervention targeting an adaptive coping style may be beneficial in selected cases. Laryngoscope, 2010
Decoy NF‐κB fortified immature dendritic cells maintain laryngeal allograft integrity and provide enhancement of regulatory T cells
Authors: Lott David G. , Dan Olivia , Lu Lina , Strome Marshall 
Published: October 2009

AbstractObjectives/Hypothesis:The increased risk of malignancy associated with post‐transplant immunosuppression limits the potential of laryngeal transplantation as a reconstructive option. This risk may be mitigated by utilizing decoy nuclear factor kappa B (NF‐κB) immature dendritic cells (iDC) to provide donor‐specific tolerance. The purpose of this study was to explore whether tolerogenic properties of iDC can be applied to composite tissue transplantation.Study Design:Animal study.Methods:Five iDC‐injected mice were euthanized at 15, 30, and 60 days post‐laryngeal transplant. Control groups included five transplanted mice without immunosuppression, one iDC‐injected mouse euthanized prior to transplantation, one mouse without injection or transplantation, and one mouse administered mature DC to serve as an accelerated rejection control. Larynges were graded for rejection severity according to a grading scale. Draining lymph nodes and spleens were evaluated by flow cytometry to determine immunogenic activity of iDC and T cells locally and peripherally.Results:Each time group demonstrated moderate allograft rejection (rejection severity scores: 4.38, 5.10, 5.29). NF‐κB iDC‐treated mice had significantly less rejection at all time points compared to nonimmunosuppressed mice. Flow cytometry showed inhibition of cytotoxic T cell infiltration and expansion of regulatory T cells at the allograft site.Conclusions:iDC immunosuppression maintains laryngeal allograft integrity up to 60 days post‐transplantation. Regulatory T cells are enhanced at the allograft site, which serves to suppress immune cell activation and induce self‐antigen tolerance. iDC injection may lessen post‐transplant comorbidities by decreasing the systemic immune response and favorably affecting concurrent immunosuppressive dose sequencing for laryngeal allograft preservation. Laryngoscope, 2010
Clarithromycin inhibits rhinovirus‐induced bacterial adhesions to nasal epithelial cells
Authors: Wang Jong Hwan , Lee Si Hyeong , Kwon Hyun Ja , Jang Yong Ju 
Published: October 2009

AbstractObjectives/Hypothesis:We investigated the inhibitory effects of clarithromycin (CM) on the rhinovirus (RV)‐induced expression of fibronectin (Fn) and carcinoembryonic antigen‐related cell adhesion molecules (CEACAMs), which act as major receptors for Staphylococcus aureus and Haemophilus influenzae, respectively. We further investigated the effects of CM on secondary S. aureus and H. influenzae adhesions to RV‐infected primary human nasal epithelial cells (HNECs).Methods:Cells were pretreated with 10 μM CM 24 hours before RV‐16 infection and for 48 hours thereafter. The expression levels of Fn and CEACAMs were assayed by reverse transcriptase‐polymerase chain reaction and Western blotting. Bacterial adhesion to cells was assessed by confocal microscopy and the fluorescence intensity of adherent bacteria was analyzed using Image‐Pro Plus 5.1 (Media Cybernetics, Bethesda, MD).Results:Clarithromycin significantly inhibited the RV‐induced gene and protein expression of Fn and CEACAMs in HNECs. Compared with RV‐infected cells, CM treatment significantly reduced the adhesion levels of S. aureus and H. influenzae in RV‐infected HNECs to the levels seen in noninfected control cells.Conclusions:These findings indicate that CM has the potential to prevent secondary bacterial infections in RV‐infected HNECs by inhibiting the expression of Fn and CEACAM, thereby interfering with bacterial adhesion. Laryngoscope, 2010
Transoral approach for plunging ranula—10‐Year experience
Authors: Huang Shiang‐Fu , Liao Chun‐Ta , Chin Shy‐Chyi , Chen I‐How 
Published: October 2009

AbstractObjective/Hypothesis:Plunging ranulas (PRs) are infrequently encountered. The origin of PRs is mostly from the sublingual gland (SLG). Different routes to manage PRs include marsupialization, simple SLG excision, and combined SLG and submandibular gland (SMG) excision either transcervically or transorally. In this study, we demonstrated our experience managing PRs via transoral excision of the SLG with marsupialization.Study Design:Retrospective study.Methods:We retrospectively reviewed 20 patients at Chang Gung Memorial Hospital, Linkou, between January 1999 and April 2009. All patients received preoperative computed tomography or magnetic resonance imaging and were clinically diagnosed with PR. At surgery, the SLG was excised transorally with preservation of Wharton's duct and lingual nerve. The mucus contents of the PRs were drained through the posterior edge of the mylohyoid muscle.Results:Two patients were found to have final diagnosis of lymphangioma. Eighteen patients were eligible for analysis. The age distribution ranged from 6 to 48 years old. Sexual distribution was equally distributed. The successful rate was 17/18 (94.4%) with a lingual nerve paresthesia rate of 2/18 (11.1%). The paresthesia persisted for 3 and 6 months, respectively. One recurrent patient was salvaged by excision of the SMG and ranula. The other two recurrent patients received excision of the SMG and cyst and had a final diagnosis of lymphangioma.Conclusions:Transoral approach with excision of the SLG alone provides a high success rate (94.4%) with minor complications and could be the first choice in managing PRs. The results of this study confirm PRs mostly originate from the SLG. Laryngoscope, 2010
Patterns of recurrence and survival of head and neck adenoid cystic carcinoma after definitive resection
Authors: Oplatek Agnes , Ozer Enver , Agrawal Amit , Bapna Sumit , Schuller David E. 
Published: October 2009

AbstractObjectives/Hypothesis:To determine factors impacting recurrence and long‐term survival of adenoid cystic carcinoma (ACC) of the head and neck after definitive resection.Study Design:Retrospective cohort study at an academic tertiary care hospital.Methods:Patients with ACC of the head and neck treated at our institution were reviewed. Those not receiving surgery, or with metastatic disease were excluded. Clinicopathological data on each patient was collected.Results:Of 113 patients identified with ACC, 99 were studied. The overall median survival for the cohort was 71 months (mean ± standard deviation, 94 ± 79 months). American Joint Committee on Cancer (AJCC) tumor stage and N stage were independent predictors of survival on multivariate analysis. Mean overall survival (P = .001) and time to recurrence (P = .006) were lower for patients with cervical lymph node positive disease (N+). Tumors in major salivary glands were associated with longer survival (P = .027). The overall recurrence rate was 53%, with a mean time to recurrence of 63 ± 64 months. The presence of lymphovascular invasion predicted recurrence on multivariate analysis (P = .002), with advanced tumor stage predicting early (≤36 months) recurrence (P = .013). Among the 57 patients who received adjuvant radiation therapy, there was no difference in survival, rate of recurrence, or time to recurrence, when compared to patients treated with surgery alone.Conclusions:Clinicopathological variables including AJCC tumor stage, tumor site, presence of N+ disease, and lymphovascular invasion may be used as prognostic factors in predicting survival and recurrence after a definitive resection of ACC of the head and neck. Laryngoscope, 2010
Improvement of respiratory compromise through abductor reinnervation and pacing in a patient with bilateral vocal fold impairment
Authors: Broniatowski Michael , Grundfest‐Broniatowski Sharon , Hadley Aaron J. , Shah Nemath S. , Barbu Anca M. , Phillipbar Sue Ann , Strohl Kingman P. , Tucker Harvey M. , Tyler Dustin J. 
Published: October 2009

AbstractObjectives/Hypothesis.To determine whether respiratory compromise from bilateral vocal fold impairment (paralysis) can be objectively alleviated by reinnervation and pacing.Methods.A patient with paramedian vocal folds and synkinesis had a tracheotomy for stridor after bilateral laryngeal nerve injury and Miller Fisher syndrome. One posterior cricoarytenoideus (PCA) received a nerve‐muscle pedicle fitted with a perineural electrode for pacemaker stimulation. The airway was evaluated endoscopically and by spirometry for up to 1 year.Results.Bilateral vocal fold patency during quiet breathing was reversed to active vocal fold adduction during tracheal occlusion. Peak inspiratory flows (PIFs) were significantly higher (P < .001) after reinnervation. PIFs and glottic apertures increased further under stimulation (42 Hz, 1–4 mA, 42–400 μsec). although the differences were not significant.Conclusions.Based on our preliminary data, PCA reinnervation and pacing offer promise for amelioration of respiratory compromise after paradoxical adduction in bilateral vocal fold impairment. Laryngoscope, 2010
Quantitative estimation of the degree of hepatic macrovesicular steatosis in a disease-free population: A single-center experience in mainland China1
Authors: Liu Zuo-Jin , Gong Jian-Ping , Yan Lv-Nan 
Published: October 2009

The aim of this study was to derive a simple equation to enable the extent of hepatic macrovesicular steatosis (HMS) to be predicted quantitatively from data obtained noninvasively and hence avoid unnecessary liver biopsies. One hundred sixty-seven potential living liver donors and 45 subjects suspected of having nonalcoholic fatty liver disease (NAFLD) underwent percutaneous liver biopsy to evaluate HMS quantitatively. Their hepatic unenhanced computed tomography (CT) attenuation, body mass index (BMI), and indices of serum lipids were reviewed. Logistic regression analysis was undertaken to screen for independent predictors of HMS. Linear regression analysis was then used to plot the relationship between the severity of histologically confirmed HMS and identified independent predictors of HMS. For potential donors with HMS of severity ≥ 5% by histological assessment, the following equation was derived:
HMS = 47.7 + 1.48BMI - 1.14CT (R
2 = 0.74)
The calculated HMS for potential donors with histologically confirmed HMS of severity < 5% seemed to be unreliable (R
2 = = 0.230, P < 0.3). In addition, in subjects suspected of having NAFLD, there was a close agreement between values for histologically confirmed HMS and calculated values for HMS derived from the equation (intraclass correlation coefficient = 0.88). Hepatic CT imaging in conjunction with other noninvasive clinical data may enable the extent of HMS to be accurately predicted with the equation derived from potential donors with appreciable degrees of histologically confirmed HMS. Liver Transpl 15:1605–1612, 2009. © 2009 AASLD.
Structural trends of 77Se1H spin–spin coupling constants and conformational behavior of 2‐substituted selenophenes
Authors: Rusakov Yury Yu. , Krivdin Leonid B. , Sauer Stephan P. A. , Levanova Ekaterina P. , Levkovskaya Galina G. 
Published: October 2009

AbstractExperimental measurements and second‐order polarization propagator approach (SOPPA) calculations of 77Se1H spin–spin coupling constants together with theoretical energy‐based conformational analysis in the series of 2‐substituted selenophenes have been carried out. A new basis set optimized for the calculation of 77Se1H spin–spin coupling constants has been introduced by extending the aug‐cc‐pVTZ‐J basis for selenium. Most of the spin–spin coupling constants under study, especially vicinal 77Se1H couplings, demonstrated a remarkable stereochemical behavior with respect to the internal rotation of the substituent in the 2‐position of the selenophene ring, which is of major importance in the stereochemical studies of the related organoselenium compounds. Copyright © 2009 John Wiley & Sons, Ltd.
3D noncontrast MR angiography of the distal lower extremities using flow‐sensitive dephasing (FSD)‐prepared balanced SSFP
Authors: Fan Zhaoyang , Sheehan John , Bi Xiaoming , Liu Xin , Carr James , Li Debiao 
Published: October 2009

AbstractWhile three‐dimensional contrast‐enhanced MR angiography (MRA) is becoming the method of choice for clinical peripheral arterial disease (PAD) examinations, safety concerns with contrast administration in patients with renal insufficiency have triggered a renaissance of noncontrast MRA. In this work, a noncontrast‐MRA technique using electrocardiography‐triggered three‐dimensional segmented balanced steady‐state free precession with flow‐sensitive dephasing (FSD) magnetization preparation was developed and tested in the distal lower extremities. FSD preparation was used to induce arterial flow voids at systolic cardiac phase while having little effect on venous blood and static tissues. High‐spatial‐resolution MRA was obtained by means of magnitude subtraction between a dark‐artery scan with FSD preparation at systole and a bright‐artery scan without FSD preparation at mid‐diastole. In nine healthy volunteers, FSD parameters, including the gradient waveform and the first‐order gradient moment, were optimized for excellent MRA image quality. Furthermore, arterial stenosis and occlusion in two peripheral arterial disease patients were identified using the noncontrast‐MRA technique, as confirmed by contrast‐enhanced MRA. In conclusion, FSD‐prepared balanced steady‐state free precession in conjunction with electrocardiography gating and image subtraction provides a promising noncontrast‐MRA strategy for the distal lower extremities. Magn Reson Med, 2009. © 2009 Wiley‐Liss, Inc.
A two‐level finite element method for the stationary Navier‐Stokes equations based on a stabilized local projection
Authors: Zhang Yan , He Yinnian 
Published: October 2009

AbstractIn this article, we propose a two‐level finite element method to analyze the approximate solutions of the stationary Navier‐Stokes equations based on a stabilized local projection. The local projection allows to circumvent the Babuska‐Brezzi condition by using equal‐order finite element pairs. The local projection can be used to stabilize high equal‐order finite element pairs. The proposed method combines the local projection stabilization method and the two‐level method under the assumption of the uniqueness condition. The two‐level method consists of solving a nonlinear equation on the coarse mesh and solving a linear equation on fine mesh. The nonlinear equation is solved by the one‐step Newtonian iteration method. In the rest of this article, we show the error analysis of the lowest equal‐order finite element pair and provide convergence rate of approximate solutions. Furthermore, the numerical illustrations coincide with the theoretical analysis expectations. From the view of computational time, the results show that the two‐level method is effective to solve the stationary Navier‐Stokes equations. © 2009 Wiley Periodicals, Inc. Numer Methods Partial Differential Eq, 2011
Structured Ti/Hydrocarbon Plasma Polymer Nanocomposites Produced By Magnetron Sputtering with Glancing Angle Deposition
Authors: Choukourov Andrei , Solar Pavel , Polonskyi Oleksandr , Hanus Jan , Drabik Martin , Kylian Ondrej , Pavlova Ewa , Slavinska Danka , Biederman Hynek 
Published: October 2009

AbstractStructured Ti/hydrocarbon plasma polymer nanocomposite films are deposited at a glancing angle by magnetron sputtering of titanium in an Ar/hexane mixture and by sequential magnetron sputtering of titanium and polypropylene. The surface chemistry of such films is tuned by adjusting the gas mixture composition. The structure of the substrate may convert the morphology of organic films deposited at a glancing angle from continuous to nanostructured thin films.magnified image
HOP is a monomer: Investigation of the oligomeric state of the co‐chaperone HOP
Authors: Yi Fang , Doudevski Ivo , Regan Lynne 
Published: October 2009

AbstractThe co‐chaperone Hsp70‐Hsp90 organizing protein (HOP) plays a central role in protein folding in vivo, binding to both Hsp70 and Hsp90 and bringing them together in a functional complex. Reports in the literature concerning the oligomeric state of HOP have been inconsistent—is it a monomer, dimer, or higher order oligomer? Knowing the oligomeric state of HOP is important, because it places limits on the number and types of multiprotein complexes that can form during the folding cycle. Thus, the number of feasible models is simplified. Here, we explicitly investigate the oligomeric state of HOP using three complementary methods: gel filtration chromatography, sedimentation equilibrium analytical ultracentrifugation (AUC), and an in vivo coexpression assay. We find that HOP does not behave like a monomeric globular protein on gel filtration. Rather its behavior is consistent with it being either an elongated monomer or a dimer. We follow‐up on these studies using sedimentation equilibrium AUC, which separates on the basis of molecular weight (MW), independent of shape. Sedimentation equilibrium AUC clearly shows that HOP is a monomer, with no indication of higher MW species. Finally, we use an in vivo coexpression assay that also supports the conclusion that HOP is a monomer.
Theoretical study of nonlinear optical properties of oxocarbon derivatives
Authors: Junqueira G. M. A. , Faria M. S. , Da Silva A. M. , Dos Santos H. F. 
Published: October 2009

AbstractIn this work, first hyperpolarizability (β) and electronic spectra were obtained at ab initio and semiempirical levels of theory for mono‐ and bi‐squarate derivatives. The results from our calculations suggest the investigated compounds as potential molecules for nonlinear optics (NLO). By means of the employed theoretical methodology, it was possible to identify structural aspects leading to enhancement of the NLO properties of the studied oxocarbons. Furthermore, a correlation between Hammett parameters of the substituents (∑σp) and ln (βtot) was established. © 2009 Wiley Periodicals, Inc. Int J Quantum Chem, 2010
Robust stability of Metzler operators under parameter perturbations
Authors: Anh Bui The , Son Nguyen Khoa 
Published: October 2009

AbstractIn this paper we study how the spectral bound of Metzler operators changes under parameter perturbations. Characterizations of the stability radii of Metzler operator with respect to this type of disturbances are established. The results generalize those obtained in (Vietnam J. Math. 2006; 34:357–368; Vietnam J. Math. 1998; 26:147–163). Copyright © 2009 John Wiley & Sons, Ltd.
Optimal two‐stage reliability studies
Authors: Browne Ryan , Steiner Stefan H. , MacKay R. Jock 
Published: October 2009

AbstractThe intraclass correlation is often used to assess the reliability of a measurement system. There is a considerable literature devoted to optimizing the standard assessment plan in which a number of subjects are measured repeatedly. We propose a two‐stage investigation, here called a leveraged plan (LP), where in Stage I, we measure a number of subjects once. Then in Stage II, we select a subset of subjects with extreme initial measurements for repeated measurement. For a fixed total number of measurements, we show that the optimal LP provides a more precise estimate of the intraclass correlation coefficient than does the optimal standard plan (SP). We provide a table for finding the optimal LP given the true intraclass correlation and a specified precision for the estimate. For a fixed total number of measurements N, a nearly optimal LP makes roughly N/2 measurements in Stage I and then selects roughly N/6 extreme subjects to re‐measure thrice each in Stage II. We also compare optimal leveraged with optimal SPs when there is a limit on the number of times each subject can be re‐measured. Copyright © 2009 John Wiley & Sons, Ltd.