bluuebunny/crossref_metadata_2025_split huggingface dataset:
An exploratory analysis of PM$$_{2.5}$$/PM$$_{10}$$ ratio during spring 2016–2018 in Metropolitan Lima
Authors: Cabello-Torres Rita Jaqueline , Carbo-Bustinza Natalí , Romero-Cabello Edison Alessandro , Ureta Tolentino Jeremias Macias , Torres Armas Elías A. , Turpo-Chaparro Josué E. , Canas Rodrigues Paulo , López-Gonzales Javier Linkolk 
Published: April 2024

AbstractAerosols (PM$$_{2.5}$$

2.5

and PM$$_{10}$$

10

) represent one of the most critical pollutants due to their negative effects on human health. This research analyzed the relationship of PM and its PM$$_{2.5}$$

2.5

/PM$$_{10}$$

10

ratios with climatic variables in the austral spring (2016–2018) in Metropolitan Lima. Overall, there was an average PM$$_{2.5}$$

2.5

/PM$$_{10}$$

10

ratio of 0.33 with fluctuations from 0.30 to 0.35. However, there have also been high point values that reached ratios greater than one. This situation indicates a moderate condition of contamination by particulate matter with a predominance of coarse aerosols in spring, with an increasing trend over the years. The locations Ate and Villa Maria del Triunfo, especially Ate, presented poor quality conditions. Thursdays showed outstanding pollution peaks by PM$$_{10}$$

10

, and a decrease is visible on Sundays. On the other hand, the PM$$_{2.5}$$

2.5

showed a similar pattern every day, including Sundays. The maximum peaks occurred in the morning and night hours. The increase in anthropogenic emissions associated with the formation of secondary aerosols has been evident, being the case of the location Campo de Marte, the one that had a significant increase in ratios PM$$_{2.5}$$

2.5

/PM$$_{10}$$

10

, which confirms a greater intensity of secondary formations of carbonaceous particles from industrial oil sources, vehicle exhaust, as well as aerosols from metal smelting and biomass burning. There were negative correlations of the ratios with PM$$_{10}$$

10

, temperature, wind speed, and direction, and positive correlations with PM$$_{2.5}$$

2.5

and relative humidity. Contour lines were successfully developed that demonstrated the interaction of climate with PM$$_{2.5}$$

2.5

/PM$$_{10}$$

10

ratios. This will deepen the exploration of emission sources and modeling, which allows for optimizing air quality indices to control emissions and adequately manage air quality in Metropolitan Lima.
Multifactorial inhibition of Candida albicans by combinations of lactobacilli and probiotic Saccharomyces cerevisiae CNCM I-3856
Authors: Spacova Irina , Allonsius Camille Nina , De Boeck Ilke , Oerlemans Eline , Tuyaerts Ines , Van de Vliet Nele , van den Broek Marianne F. L. , Jimenez Luciana , Boyer Mickaël , Rodriguez Bertrand , Ballet Nathalie , Lebeer Sarah 
Published: April 2024

AbstractStrategies against the opportunistic fungal pathogen Candida albicans based on probiotic microorganisms represent a promising alternative to traditional antifungals. Here, we investigated the effects of Lactobacillaceae isolates from fermented foods or the human vagina, alone or in combination with the probiotic yeast Saccharomyces cerevisiae CNCM I-3856, against C. albicans in vitro. Nine out of nineteen tested strains of Lactobacillaceae inhibited growth of C. albicans with inhibition zones of 1–3 mm in spot assays. Five out of nineteen lactobacilli tested as such or in combination with S. cerevisiae CNCM I-3856 also significantly inhibited C. albicans hyphae formation, including Limosilactobacillus fermentum LS4 and L. fermentum LS5 resulting in respectively 62% and 78% hyphae inhibition compared to the control. Thirteen of the tested nineteen lactobacilli aggregated with the yeast form of C. albicans, with Lactiplantibacillus carotarum AMBF275 showing the strongest aggregation. The aggregation was enhanced when lactobacilli were combined with S. cerevisiae CNCM I-3856. No significant antagonistic effects were observed between the tested lactobacilli and S. cerevisiae CNCM I-3856. The multifactorial activity of Lactobacillaceae strains alone or combined with the probiotic S. cerevisiae CNCM I-3856 against C. albicans without antagonistic effects between the beneficial strains, paves the way for developing consortium probiotics for in vivo applications.
Single-cell transcriptomics in MI identify Slc25a4 as a new modulator of mitochondrial malfunction and apoptosis-associated cardiomyocyte subcluster
Authors: Zhou Ting , Pan Jing , Xu Kai , Yan Chenghui , Yuan Jing , Song Haixu , Han Yaling 
Published: April 2024

AbstractMyocardial infarction (MI) is the leading cause of premature death. The death of cardiomyocytes (CMs) and the dysfunction of the remaining viable CMs are the main pathological factors contributing to heart failure (HF) following MI. This study aims to determine the transcriptional profile of CMs and investigate the heterogeneity among CMs under hypoxic conditions. Single-cell atlases of the heart in both the sham and MI groups were developed using single-cell data (GSE214611) downloaded from Gene Expression Omnibus (GEO) database (https://www.ncbi.nlm.nih.gov/geo/). The heterogeneity among CMs was explored through various analyses including enrichment, pseudo time, and intercellular communication analysis. The marker gene of C5 was identified using differential expression analysis (DEA). Real-time polymerase chain reaction (RT-PCR), bulk RNA-sequencing dataset analysis, western blotting, immunohistochemical and immunofluorescence staining, Mito-Tracker staining, TUNEL staining, and flow cytometry analysis were conducted to validate the impact of the marker gene on mitochondrial function and cell apoptosis of CMs under hypoxic conditions. We identified a cell subcluster named C5 that exhibited a close association with mitochondrial malfunction and cellular apoptosis characteristics, and identified Slc25a4 as a significant biomarker of C5. Furthermore, our findings indicated that the expression of Slc25a4 was increased in failing hearts, and the downregulation of Slc25a4 improved mitochondrial function and reduced cell apoptosis. Our study significantly identified a distinct subcluster of CMs that exhibited strong associations with ventricular remodeling following MI. Slc25a4 served as the hub gene for C5, highlighting its significant potential as a novel therapeutic target for MI.
RAPID resistance to BET inhibitors is mediated by FGFR1 in glioblastoma
Authors: Jermakowicz Anna M. , Kurimchak Alison M. , Johnson Katherine J. , Bourgain-Guglielmetti Florence , Kaeppeli Simon , Affer Maurizio , Pradhyumnan Hari , Suter Robert K. , Walters Winston , Cepero Maria , Duncan James S. , Ayad Nagi G. 
Published: April 2024

AbstractBromodomain and extra-terminal domain (BET) proteins are therapeutic targets in several cancers including the most common malignant adult brain tumor glioblastoma (GBM). Multiple small molecule inhibitors of BET proteins have been utilized in preclinical and clinical studies. Unfortunately, BET inhibitors have not shown efficacy in clinical trials enrolling GBM patients. One possible reason for this may stem from resistance mechanisms that arise after prolonged treatment within a clinical setting. However, the mechanisms and timeframe of resistance to BET inhibitors in GBM is not known. To identify the temporal order of resistance mechanisms in GBM we performed quantitative proteomics using multiplex-inhibitor bead mass spectrometry and demonstrated that intrinsic resistance to BET inhibitors in GBM treatment occurs rapidly within hours and involves the fibroblast growth factor receptor 1 (FGFR1) protein. Additionally, small molecule inhibition of BET proteins and FGFR1 simultaneously induces synergy in reducing GBM tumor growth in vitro and in vivo. Further, FGFR1 knockdown synergizes with BET inhibitor mediated reduction of GBM cell proliferation. Collectively, our studies suggest that co-targeting BET and FGFR1 may dampen resistance mechanisms to yield a clinical response in GBM.
The model of norm-regulated responsibility for proenvironmental behavior in the context of littering prevention
Authors: Ai Pengya , Rosenthal Sonny 
Published: April 2024

AbstractPrevious research suggests that descriptive norms positively influence proenvironmental behavior, including littering prevention. However, in some behavioral contexts, a weak descriptive norm may increase individuals’ feelings of responsibility by signaling a need for action. We examined this effect in the context of litter prevention by conducting structural equation modeling of survey data from 1400 Singapore residents. The results showed that descriptive norms negatively predicted ascription of responsibility and were negatively related to littering prevention behavior via ascription of responsibility and personal norms. It also showed that strong injunctive norms can reduce the inhibitory effect of descriptive norms on ascription of responsibility. These findings were consistent with several hypotheses constituting the model of norm-regulated responsibility, a novel explanatory framework offering new insights and a more nuanced and comprehensive understanding of social norms’ influence on proenvironmental behavior.
Modeling the effect of autonomous vehicles (AVs) on the accessibility of the transportation network
Authors: Mirzahossein Hamid , Mashhadloo Mahdis 
Published: April 2024

AbstractThe utilization of autonomous vehicles (AVs) has emerged as a pivotal factor in addressing the rising costs and safety concerns associated with modern travel. As technology advances and traffic challenges intensify, enhancing accessibility stands out as a critical goal for transportation experts. Accessibility, constrained by factors like travel time, underscores the increasing need for AVs to mitigate these limitations. This study aimed to model the influence of AVs on the accessibility index within transportation networks and discuss system optimization based on user equilibrium (UE) and system optimum (SO) outcomes. The research conducted numerical analysis employing the Hearn network as a fundamental system to validate a mixed assignment model and ascertain baseline accessibility. Additionally, the Sioux Falls network, a medium-sized network, was employed for analysis. A hybrid heuristic assignment algorithm was introduced, concurrently assigning different percentages of AV presence alongside the remaining non-AV percentage in three distinct scenarios. These scenarios ranged from 0 to 100% AV presence: the first scenario maintained constant network capacity, the second scenario adjusted network capacity based on AV presence, and the third scenario incorporated capacity adjustments in the assignment stage. In all three scenarios, network accessibility was evaluated using gravity and accessibility index methods derived from the hybrid assignment model output. The findings demonstrated that as the percentage of AVs increased, accessibility improved in both Hearn and Sioux Falls networks across all scenarios. The second and third scenarios exhibited higher accessibility increases compared to the first, attributable to augmented capacity resulting from increased AV presence. In the Sioux Falls network, the first scenario showed enhanced SO and UE due to increased AV presence and enhanced system operator management. Conversely, the second and third scenarios, with increased AVs and subsequent capacity increments, displayed reduced UE and SO results. Despite the decline in UE and SO, traffic flow assignment and overall network accessibility improved. These findings highlight the positive correlation between AV presence, network capacity, and enhanced accessibility. The study underscores the potential benefits of AV integration in optimizing transportation networks and improving overall accessibility, albeit with nuances in capacity adjustments impacting traffic flow dynamics. Further research avenues could explore complex traffic flow scenarios and delve into more specific optimization strategies.
Neural networks and particle swarm for transformer oil diagnosis by dissolved gas analysis
Authors: Guerbas Fettouma , Benmahamed Youcef , Teguar Youcef , Dahmani Rayane Amine , Teguar Madjid , Ali Enas , Bajaj Mohit , Dost Mohammadi Shir Ahmad , Ghoneim Sherif S. M. 
Published: April 2024

AbstractThe lifetime of power transformers is closely related to the insulating oil performance. This latter can degrade according to overheating, electric arcs, low or high energy discharges, etc. Such degradation can lead to transformer failures or breakdowns. Early detection of these problems is one of the most important steps to avoid such failures. More efficient diagnostic systems, such as artificial intelligence techniques, are recommended to overcome the limitations of the classical methods. This work deals with diagnosing the power transformer insulating oil by analysis of dissolved gases using new techniques. For this, we have proposed intelligent techniques based on Multilayer artificial neural networks (ANN). Thus, a multi-layer ANN-based model for fault detection is presented. To improve its classification rate, this one was optimized by a meta-heuristic technique as the particle swarm optimization (PSO) technique. Optimized ANNs have never been used in transformer insulating oil diagnostics so far. The robustness and effectiveness of the proposed model is demonstrated, and high accuracy is obtained.
Characterization of polyphenols and carbohydrates exuded by Phaeodactylum tricornutum diatom grown under Cu stress
Authors: Rico Milagros , Santiago-Díaz Paula , Rivero Argimiro , Santana-Casiano Juana Magdalena 
Published: April 2024

AbstractThis study is focused on analysing polyphenols and carbohydrates released by Phaeodactylum tricornutum (P. tricornutum) diatoms cultured in natural seawater enriched with sublethal and lethal Cu doses. Cu concentrations of 0.31, 0.79 and 1.57 µM reduced cell densities by 37, 82 and 91%, respectively, compared to the control. The total sum of all identified polyphenols and total carbohydrates released by cells grown under lethal Cu levels increased up to 18.8 and 107.4 times, respectively, compared to data from a control experiment. Four different in vitro assays were used to estimate the antioxidant activities of the extracellular compounds: 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical inhibition, cupric ion reducing antioxidant capacity (CUPRAC), ferric reducing antioxidant power and Cu complexing ability (CCA). The highest antioxidant activities were observed in the Cu lethal treatments, where the CCA assay exhibited a greater increase (up to 32.2 times higher than that found in the control experiment) to reduce the concentration of free Cu in the medium and its toxicity. The presence of Cu stimulated the release of polyphenols and carbohydrates to the medium as a detoxification mechanism to survive under lethal levels of Cu regulating its speciation.
A synthetic methylotrophic Escherichia coli as a chassis for bioproduction from methanol
Authors: Reiter Michael A. , Bradley Timothy , Büchel Lars A. , Keller Philipp , Hegedis Emese , Gassler Thomas , Vorholt Julia A. 
Published: April 2024

AbstractMethanol synthesized from captured greenhouse gases is an emerging renewable feedstock with great potential for bioproduction. Recent research has raised the prospect of methanol bioconversion to value-added products using synthetic methylotrophic Escherichia coli, as its metabolism can be rewired to enable growth solely on the reduced one-carbon compound. Here we describe the generation of an E. coli strain that grows on methanol at a doubling time of 4.3 h—comparable to many natural methylotrophs. To establish bioproduction from methanol using this synthetic chassis, we demonstrate biosynthesis from four metabolic nodes from which numerous bioproducts can be derived: lactic acid from pyruvate, polyhydroxybutyrate from acetyl coenzyme A, itaconic acid from the tricarboxylic acid cycle and p-aminobenzoic acid from the chorismate pathway. In a step towards carbon-negative chemicals and valorizing greenhouse gases, our work brings synthetic methylotrophy in E. coli within reach of industrial applications.
Spectroscopic evidence of a possible young stellar cluster at the Galactic Center
Authors: Martínez-Arranz A. , Schödel R. , Nogueras-Lara F. , Najarro F. , Castellanos R. , Fedriani R. 
Published: April 2024

Context. The nuclear stellar disk has been the most prolific star-forming region in the Milky Way over the past ∼30 million years. Notably, the cumulative mass of the three clusters currently found in the nuclear stellar disk, the Quintuplet, the Arches, and the Nuclear clusters, amounts to just 10% of the total anticipated mass of young stars that formed in this period. This discrepancy, known as the missing cluster problem, is attributed to factors such as high stellar density and tidal forces. Traces of dissolving clusters may exist as comoving groups of stars, providing insights into the star formation history of the region. Recently, a new cluster candidate associated with an HII region was reported through the analysis of kinematic data
Aims. Our aim is to determine whether the young and massive stellar objects in the region share proper motion, positions in the plane of the sky, and line-of-sight distances. We use reddening as a proxy for the distances.
Methods. We reduced and analyzed integral field spectroscopy data from the KMOS instrument at the ESO VLT to locate possible massive young stellar objects in the field. Then, we identified young massive stars with astrophotometric data from the two different catalogs to analyze their extinction and kinematics.
Results. We present a group of young stellar objects that share velocities, are close together in the plane of the sky, and are located at a similar depth in the nuclear stellar disk.
Conclusions. The results presented here offer valuable insights into the missing clusters problem. They indicate that not all young massive stars in the Galactic center form in isolation; some of them seem to be the remnants of dissolved clusters or stellar associations.
Endoscopic transoral outlet reduction induces enterohormonal changes in patients with weight regain after Roux-en-Y gastric bypass
Authors: Brunaldi Vitor Ottoboni , Farias Galileu Ferreira , de Moura Diogo Turiani Hourneaux , Santo Marco Aurélio , Abu Dayyeh Barham K. , Faria Caroline Silverio , Antonangelo Leila , Waitzberg Dan Linetzki , de Moura Eduardo Guimarães Hourneaux 
Published: April 2024

Abstract
Background and study aims Transoral outlet reduction (TORe) has long been employed in treating weight regain after Roux-en-Y gastric bypass. However, its impact on gut hormones and their relationship with weight loss remains unknown.
Patients and methods This was a substudy of a previous randomized clinical trial. Adults with significant weight regain and dilated gastrojejunostomy underwent TORe with argon plasma coagulation (APC) alone or APC plus endoscopic suturing (APC-suture). Serum levels of ghrelin, GLP-1, and PYY were assessed at fasting, 30, 60, 90, and 120 minutes after a standardized liquid meal. Results were compared according to allocation group, clinical success, and history of cholecystectomy.
Results Thirty-six patients (19 APC vs. 17 APC-suture) were enrolled. There were no significant baseline differences between groups. In all analyses, the typical postprandial decrease in ghrelin levels was delayed by 30 minutes, but no other changes were noted. GLP-1 levels significantly decreased at 12 months in both allocation groups. Similar findings were noted after dividing groups according to the history of cholecystectomy and clinical success. The APC cohort presented an increase in PYY levels at 90 minutes, while the APC-suture group did not. Naïve patients had significantly lower PYY levels at baseline (P = 0.01) compared with cholecystectomized individuals. This latter group experienced a significant increase in area under the curve (AUC) for PYY levels, while naïve patients did not, leading to a higher AUC at 12 months (P = 0.0001).
Conclusions TORe interferes with the dynamics of gut hormones. APC triggers a more pronounced enteroendocrine response than APC-suture, especially in cholecystectomized patients.
Situated minds and distributed systems in translation
Authors: Sannholm Raphael , Risku Hanna 
Published: April 2024

AbstractThis article sheds light on two different perspectives on the boundaries of the cognitive system and the consequences of their adoption for Cognitive Translation and Interpreting Studies (CTIS). Both are represented by different approaches within the cognitive scientific cluster of approaches referred to as situated or 4EA (embodied, embedded, enactive, extended, and affective) cognition. The first, the person-centred perspective, takes individuals as a starting point and describes their interactions with their social and material surroundings. The second, the distributed, extended perspective, takes the joint activity of different situated actors and material artefacts as its starting point and depicts this socio-cognitive unit as the object of analysis. With this article, we do not seek to advocate the use of one over the other. Rather, we attempt to offer a coherent interpretation of how the cognitive process of translation can be studied and interpreted as a situated activity either from the perspective of individual actors or from a larger, distributed, and extended angle that considers people and the relevant social and material environment as a system. Specifically, we discuss what is to be gained if translation is studied from a distributed cognitive perspective. To this end, we illustrate key aspects of the discussion using empirical examples from current field research in which both an individual and a distributed perspective are applied to analyse interaction in a translation workplace.
Bipolar complex fuzzy submodules
Authors: Alsuraiheed Turki , ur Rehman Ubaid , Khan Meraj Ali , Mahmood Tahir 
Published: April 2024

Abstract
In this manuscript, we interpret the theory of bipolar complex fuzzy submodule (BCFSM) of a provided classical module over a ring by utilizing the well-known notion of bipolar complex fuzzy set (BCFS). We also devise the sum of two BCFS and investigate its related proposition for studying a few fundamental properties of the initiated BCFSM. Moreover, we investigate the cartesian product of two BCFS for developing properties of BCFSM. We also investigate that if a BCFS

Ӈ

1

is a BCFSM of

Ӎ

1

,

then image

Ӻ

Ӈ

is a BCFSM of

Ӎ

2

and the preimage

Ӻ

−
1

Ӈ

is a BCFSM of

Ӎ

1

,

where,

Ӎ

1

and

Ӎ

2

are two modules and

Ӻ
:

Ӎ

1

→

Ӎ

2

is a module homomorphism.