bluuebunny/crossref_metadata_2025_split huggingface dataset:
Synthesis and reactivity of new l‐(1‐adamantyl)pyrazoles
Authors: Cabildo P. , Claramunt R. M. , Elguero J. 
Published: April 2009

AbstractUsing 1‐adamantylhydrazine as starting material, a series of 1‐(1‐adamantyl)pyrazoles has been prepared. Electrophilic reactivity (bromination and nitration) and nucleophilic reactivity (quaternarization) have been studied. Proton nuclear magnetic resonance spectra of all the new compounds are recorded.
Reaction of 2‐phenyl‐4‐methyl‐Δ2‐oxazolin‐5‐one with imines. A convenient synthesis of 3‐amido‐β‐lactams
Authors: Sain B. , Baruah J. N. , Sandhu J. S. 
Published: April 2009

AbstractAzlactone 3a reacted with furan‐2‐aldehyde and thiophene‐2‐aldehyde imines to give corresponding 3‐amido‐β‐lactams in good yields.
Basicity of azoles. IV. Empirical relationships between basicity and ionization potential for aromatic five membered rings containing nitrogen or oxygen
Authors: Catalán Javier , Elguero José 
Published: April 2009

AbstractA plot of pKa values for eleven azoles and benzazoles vs the experimental ionization energy of the nitrogen lone pair shows the existence of three groups of compounds: simple unsubstituted azoles (imidazole, pyrazole, oxazole, isoxazole), unsubstituted benzazoles (benzimidazole, 1H‐indazole and benzoxazole, including imidazo [1,2‐a]pyridine) and benzazoles carrying a methyl group α‐ to the basic centre (2‐methylbenzimidazole, 2‐methylindazole and 2‐methylbenzoxazole).
The reaction of lithium phenylacetylide and phenyllithium with N‐(ω‐Bromoalkyl)phthalimides
Authors: Torian Bruce E. , Braun Loren L. 
Published: April 2009

AbstractLithium phenylacetylide reacted with short‐chain N‐(ω‐bromoalkyl)phthalimides 1b and 1c to give tricyclic products 2b and 2c in moderate yields. Likewise, tricyclic products 3a‐c were obtained when short‐chain imides 1a‐c were treated with phenyllithium. When longer‐chain imides 1d‐f in this series were treated with lithium phenylacetylide only tertiary alcohols 4d‐f could be isolated. Partial hydrogenation of 2b and 2c yielded the corresponding alkenes 5b and 5c, products which corroborated the structural assignment of 2b and 2c.
A facile and general entry to optically active pheromones and aromas with γ‐alkyl‐γ‐lactone structures. A study of some lactone derivatives of pentoses
Authors: Cardellach J. , Font J. , Ortuño R. M. 
Published: April 2009

AbstractA new and easy general methodology has been developed to prepare γ‐alkyl‐α,β‐butenolides or γ‐alkylbutyrolactones in four and five steps, respectively, from D‐ribonolactone as a common chiral starting material. Some of these products have pheromonal activity in insects and are also used as fruit fragrances. A study on several derivatives of D‐ribonolactone and 2‐deoxy‐D‐ribonolactone has been carried out in order to explore alternative routes for these syntheses.
Application of the okahara cyclization to the preparation of crown ethers with aromatic units
Authors: Czech B. , Czech A. , Bartsch R. A. 
Published: April 2009

AbstractA series of crown ethers with single benzene, naphthalene, biphenyl and binaphthyl units are prepared by the intramolecular Okahara cyclization of appropriate symmetrical diols. The method is used to synthesize new crown ether compounds and to prepare previously‐reported crown ethers in improved yields.
Reaction of dichloroketene and sulfene with N,N‐disubstituted α‐aminomethyleneketones. Synthesis of pyrano[2,3‐e]indazole and 1,2‐oxathiino[6,5‐e]indazole derivatives
Authors: Mosti Luisa , Menozzi Giulia , Schenone Pietro 
Published: April 2009

AbstractThe polar 1,4‐cycloaddition of dichloroketene to N,N‐disubstituted (E)‐5‐aminomethylene‐1,5,6,7‐tetrahydro‐(1‐methyl)(1‐phenyl)‐4H‐indazol‐4‐ones V, prepared from 1,5,6,7‐tetrahydro‐(1‐methyl)(1‐phenyl)‐4H‐indazol‐4‐ones via the 5‐hydroxymethylene derivatives, gave in good yield N,N‐disubstituted 4‐amino‐3,3‐dichloro‐4,5,6,7‐tetrahydro‐(7‐methyl)(7‐phenyl)pyrano[2,3‐e]indazol‐(3H)ones VI, which are derivatives of the new heterocyclic system pyrano[2,3‐e]indazole. Dehydrochlorination of VI with DBN afforded N,N‐disubstituted 4‐amino‐3‐chloro‐6,7‐dihydro(7‐methyl)(7‐phenyl)pyrano[2,3‐e]indazol‐2(5H]‐ones VII generally in satisfactory yield. Full aromatization with DDQ of VII was tried only in the case of dimethylamino derivatives, giving a moderate yield of 3‐chloro‐4‐dimethylamino(7‐methyl)(7‐phenyl)pyrano[2,3‐e]indazol‐2(7H)‐ones. Cycloaddition of sulfene to V occurred only in the case of aliphatic N‐substitution to give in moderate yield 4‐dialkylamino‐4,5,6,7‐tetrahydro‐(7‐methyl)(7‐phenyl)‐3H‐1,2‐oxathiino[6,5‐e]indazole 2,2‐dioxides, which are derivatives of the new heterocyclic system 1,2‐oxathiino[6,5‐e]indazole.
Reaction of nitriles under acidic conditions. Part III. A facile synthesis of thienopyrimidin‐4(3H)‐ones
Authors: Shishoo C. J. , Devani M. B. , Pathak U. S. , Ananthan S. , Bhadti V. S. , Ullas G. V. , Jain K. S. , Rathod I. S. , Talati D. S. , Doshi N. H. 
Published: April 2009

AbstractA variety of thiophene o‐aminoesters were reacted with cyanates, thiocyanates, cyanamides, acyl cyanides and α‐functionalized acetonitrile derivatives to yield the corresponding 2‐substituted thienopyrimidin‐4(3H)‐ones.
Ylides of heterocycles. VII.. I‐, N‐, P‐ and S‐ylides of pyrimidones
Authors: Habib Nargues Samuel , Kappe Thomas 
Published: April 2009

AbstractThe reaction of pyrimidone derivatives 1a‐d with iodosobenzene prepared in situ from diacetoxyiodobenzene or dichloroiodobenzene afforded the iodonium‐ylides 2a‐d in good yields. Their thermal rearrangement produced 5‐iodo‐4‐phenoxy‐pyrimidin‐6(1H)‐ones 3a‐c. Reductive deiodination of 3 gave the corresponding 4‐phenoxypyrimidin‐6(1H)‐ones 4a‐c. Acid catalized treatment of the iodonium‐ylides 2a‐d with nucleophiles such as pyridine, nicotinamide, isoquinoline, or triphenylphosphine produced the corresponding N‐ or P‐ylides 7, 8, 9, and 10, respectively. The thiophanium‐ylides 11a,c were obtained from the iodonium‐ylides 2 without the use of a catalyst. The pyridinium‐ylides 7 have been also prepared from the 5‐halopyrimidones 5 or 6 which in turn could be obtained from the reactive iodonium‐ylides 2 with hydrochloric or hydrobromic acid, respectively.
A simple and stereoselective synthesis of 7‐azabicyclo[2.2.1]‐heptane‐1,2,3,4‐tetracarboxylates
Authors: Zaima Tadataka , Matsuno Chikashi , Matsunaga Yoshiharu , Mitsuhashi Keiryo 
Published: April 2009

AbstractThe photoinitiated reaction of 1,1′‐bis(methoxycarbonyl)divinylamine with various maleates and fumarates afforded novel 7‐azabicyclo[2.2.1]heptane‐1,2,3,4‐tetracarboxylates. The spectral investigation of the products showed that the reaction proceeded stereoselectively, retaining the original configuration of the reagents.
Heterocycles from nitrile oxides. II . 1,2,4‐oxadiazin‐6‐ones
Authors: Hussein Ahmad Q. , El‐Abadelah Mustafa M. , Sabri Wail S. 
Published: April 2009

AbstractCondensation of arylnitrile oxides with α‐amino acid esters, other than those of glycine and analine, has been found to constitute a synthetic route to the hitherto unknown 1,2,4‐oxadiazin‐6‐ones 7. α‐Amino alcohols yield with nitrile oxides the corresponding acyclic N‐(arylhydroxamoyl)amino alcohols, which are also accessible by borohydride reduction of compounds 7. In contrast, the adducts formed from nitrile oxides and α‐amino acids are unstable; they decompose readily into the aldehyde, derived from the amino acid, together with the aldoxime, derived from the nitrile oxide. Both decomposition products are also formed when compounds 7 are subjected to mild hydrolysis.
New synthesis of pyrazole and isoxazole derivatives
Authors: Molina P. , Fresneda P. M. 
Published: April 2009

AbstractA convenient synthesis of 5‐aryl‐1‐phenylpyrazoles and 5‐arylisoxazoles, from readily available ketimine 1 dimethylformamide dimethylacetal and phenylhydrazine or hydroxylamine, is described.
Substitution and ring closure reactions of phthalazine derivatives
Authors: Badr M. Z. A. , El‐Sherief H. A. , El‐Naggar G. M. , Mahgoub S. A. 
Published: April 2009

Abstract1‐(Phenylthio)‐ and 1‐(hydroxycarbonylmethylthio)‐4‐methylphthalazines were prepared from 1‐chloro‐4‐methylphthalazines (1). A series of 2‐benzyl‐ and benzenesulphonyl derivatives was prepared from the corresponding halides and 4‐methyl‐1(2H)‐phthalazinone (4). 4‐Methyl‐1(2H)‐phthalazinthione (6) was substituted at SH group to give 1‐(benzylthio)‐ and 1‐(ethoxycarbonylmethylthio)‐4‐methylphthalazines, 7 and 8 respectively. Treatment of hydrazine hydrate with 8 produced 1‐hydrazino‐4‐methylphthalazine (10). However, when the latter compound was treated with 1 it gave 1,2‐bis‐(4‐methylphthalazinyl)hydrazine.Treatment of 10 with aromatic aldehydes in glacial acetic acid gave the corresponding 3‐phenyl‐s‐triazolo‐[3,4‐a]‐6‐methylphthalazines 13. 1‐Hydrazino‐4‐methylphthalazine (10) underwent cyclization reactions with acetic anhydride, ethyl chloroformate, carbon disulphide, ethylformate, ethyl oxalate and with nitrous acid to give the corresponding triazolo‐, triazino‐ and tetrazolophthalazine compounds.
Convenient synthesis of arylazo derivatives of quinoxaline, 1,4‐benzothiazine, and 1,4‐benzoxazine
Authors: Párkányi Cyril , Abdelhamid Abdou O. , Shawali Ahmad S. 
Published: April 2009

AbstractArylazo derivatives of quinoxaline (1,4‐benzodiazine), 1,4‐benzothiazine, and 1,4‐benzoxazine have been prepared by condensation of hydrazidoyl halides with o‐phenylenediamine, o‐aminothiophenol, and o‐aminophenol, respectively (Table I). This method seems to be more general than the approach using coupling of reactive diazonium salts with, e.g., 277–1,4‐benzothiazine. Both the spectral data and the results of HMO calculations of bonding energies of the azo compounds obtained in this study indicate that they exist predominantly in the hydrazone tautomeric form.
Dehydrogenation reactions of 1‐substituted‐3‐aryltetrahydroisoquinoline derivatives
Authors: Domínguez Esther , Lete Esther 
Published: April 2009

AbstractThe 1‐substituted‐3‐aryltetrahydroisoquinolines I have been converted into the corresponding 3,4‐dihydroor isoquinoline derivatives by treatment with several oxidizing agents: iodine in ethanol, palladium on carbon, DDQ and Fremy's salt. The oxidation reactions with iodine always resulted in the formation of the 3,4‐dihydroisoquinolines II, whereas the use of palladium on carbon and the DDQ led to the aromatic isoquinolines. Both the 3,4‐dihydro‐ and the isoquinoline derivatives were obtained by means of Fremy's salt.
Facile synthesis of 5‐(α‐alkyl‐substituted) furans
Authors: Adembri Giorgio , Anselmi Cecilia , Celli Angela M. , Lampariello Lucia R. , Scotton Mirella 
Published: April 2009

Abstract2‐Halo, 2‐hydroxy‐ or 2‐alkoxyalkyl substituted furans are easily synthesized under acidic conditions by intramolecular cyclization of α,β‐unsaturated 1,4‐diketones by a simple and cheap procedure. Some aspects of the mechanism are discussed.
Synthesis of 1H‐imidazo[3′,4′:4,5]thieno[2,3‐b]pyridines. A new ring system
Authors: Guerrera Francesco , Siracusa Maria Angela , Tornetta Benedetto , Bousquet And Ennio , Agozzino Pasquale , Lamartina Liliana 
Published: April 2009

AbstractA facile and convenient synthesis of the title compounds is described, using as starting materials the 2‐nitro‐3‐aminothieno[2,3‐b]pyridines. Mass spectral data of the above mentioned compounds are briefly discussed.
Synthesis of 1,4‐bis(4‐pyridyl)butadiyne
Authors: Ciana Leopoldo Delia , Haim Albert 
Published: April 2009

Abstract2‐Methyl‐4‐(4‐pyridyl)‐3‐butyn‐2‐ol (2) was prepared in 70% yield by the reaction of 4‐bromopyridine with 2‐methyl‐3‐butyn‐2‐ol in diethylamine in the presence of bis(triphenylphosphine)palladium(II) chloride and copper(I) iodide. Removal of the protective group in 2 by refluxing with sodium hydroxide in toluene yields (90%) 4‐ethynylpyridine (3). Oxidative coupling of 3 in pyridine by dioxygen in the presence of copper(I) chloride produces a 92% yield of 1,4‐bis(4‐pyridyl)butadiyne.
Synthesis of 5,7‐dichloro‐2H‐1‐benzopyran‐2‐ol
Authors: Stokker G. E. 
Published: April 2009

AbstractThe reaction of 4,6‐dichloro‐2‐(methylthiomethoxy)cinnamaldehyde (3) or 4,6‐dichloro‐2‐hydroxycinnamaldehyde (5) with mercuric chloride in hot aqueous acetonitrile gave 5,7‐dichloro‐2H‐1‐benzyopyran‐2‐ol (4) in good yield.
Reactions of 3‐acetyl‐2‐aminotropones and 2‐acetyl‐7‐aminotropones with hydrazine
Authors: Imafuku Kimiaki , Shimazu Akiko 
Published: April 2009

Abstract3‐Acetyl‐2‐aminotropone (1a) reacted with hydrazine to afford its hydrazone (3a) and 3‐methyl‐1,8‐dihydrocycloheptapyrazol‐8‐one (4), while methylamino‐ and pyrrolidinyl‐substituted compounds 1b and 1c gave only the cyclized compound (4). Reactions of 2‐acetyl‐7‐aminotropones 2a‐d gave their hydrazones 5a‐d and the hydrazone 6. The hydrazones 3a and 5b were heated in acetic acid to give 4 and 3‐methyl‐8‐methylamino‐1,2‐diazaazulene (7), respectively. Several reactions of 4 and 6 were also described.
Synthesis of C‐nucleoside isosteres of 9‐(2‐hydroxyethoxymethyl)guanine (acyclovir)
Authors: Mitchell William L. , Hill Malcolm L. , Newton Roger F. , Ravenscroft Paul , Scopes David I. C. 
Published: April 2009

AbstractSyntheses of 2‐amino‐7‐(2‐hydroxyethoxymethyl)imidazo[5,1‐f]‐1,2,4‐triazin‐4(3H)‐one (2) and 6‐amino‐3‐(2‐hydroxyethoxymethyl)‐1,2,4‐triazolo[3,4‐f]‐1,2,4‐triazin‐8(7H)‐one (3), novel isosteres of the antiviral agent acyclovir, are reported.
The reactions of some ortho‐substituted anilines with various α,β‐acetylenic ketones. A route to substituted quinolines
Authors: Sinsky M. S. , Bass R. G. 
Published: April 2009

AbstractThe reactions of some ortho‐substituted anilines with various α,β‐acetylenic ketones were investigated as a route to 4‐alkyl‐, 4‐aryl‐, 4‐hydroxy‐, and 4‐amino‐3‐quinolyl ketones. The anilines examined were 2‐aminoacetophenone (1), 2‐aminobenzophenone (2), anthranilonitrile (3), methyl anthranilate (4), and ethyl anthranilate (5). The acetylenic ketones used were 1,4‐diphenyl‐2‐butyne‐1,4‐dione (6), 3‐butyn‐2‐one (7), 1,3‐diphenyl‐2‐propyn‐1‐one (8), and 4‐phenyl‐3‐butyn‐2‐one (9). The acetylenic ketones typically reacted with the anilines to give enamines; however, exceptions were found. Acetylene 6 reacts with 3 to give the enamine (13) along with a small amount of 2,3‐dibenzoyl‐4‐quinolamine (14). The reactions of 1 or 2 with 6 give the respective quinoline derivatives directly. Acetylene 8 reacts with 2 to give 3‐benzoyl‐2,4‐diphenylquinoline (22) directly, whereas no reaction occurs between 8 and 1 or 3. Acetylene 9 does not react with 1, 2, or 3. The enamines exist as the intramolecularly hydrogen bonded isomers and usually undergo cyclization with 5 molar equivalents of methanolic sodium methoxide to give quinoline derivatives. The 4‐quinolinols exist predominantly as the 4‐quinolinone tautomer.
2H‐3,1‐benzoxazine‐2,4‐(1H)‐dione (isatoic anhydride). 15. Reactions with lactone enolates
Authors: Coppola Gary M. 
Published: April 2009

AbstractThe reaction of N‐methylisatoic anhydride, 1, with the lithium enolates derived from various butyrolactones or δ‐valerolactone produces stable anthranoyl lactone derivatives 4. Heating these products in toluene results in a cyclization to afford 4‐hydroxy‐3‐(2‐hydroxyalkyl)‐1‐methyl‐2(1H)‐quinolinones, 8 and 14, in good yields.
The reaction of isothiocyanates with 2‐cyanoethanoic acid hydrazide. A novel synthesis of 1,3,4‐thiadiazoles
Authors: Elmoghayar Mohamed Rifaat Hamza , Abdalla Sanaa Osman , Nasr Mohamed Yousry Abdel‐Samad 
Published: April 2009

AbstractBenzoyl and ethoxycarbonyl isothiocyanates reacted with 2‐cyanoethanoic acid hydrazide 2 to afford 1‐cyanoacetyl‐4‐substituted thiosemicarbazide (5a,b). Compound 5a afforded the pyrazolo[1,5‐a]‐s‐triazine derivative 6 on treatment with 5% potassium hydroxide, and cyclised to 2‐benzoylamino‐5‐cyanomethyl‐1,3,4‐thiadiazole (8) when boiled under reflux in glacial acetic acid. Compound 8 condensed with aromatic aldehydes to yield the corresponding arylidene derivatives 9a‐c. It undergoes coupling with aromatic diazonium salts to afford the hydrazones 11a‐c. Similarly, it coupled with diazotised aminopyrazole to afford the cyclic product 12.
Synthesis of some triazole, tetrazole, and tetrazine derivatives from N‐β‐naphthalenesulfonylbenzohydrazidoyl chlorides
Authors: Hassaneen Hamdi M. , Fahmi Abdelgawad A. , Abdelhamid Hyam , Yassin Ahmady A. , Shawali Ahmad S. 
Published: April 2009

AbstractA series of N‐β‐naphthalenesulfonylbenzohydrazidoyl chlorides 8a‐d has been prepared by the action of thionyl chloride on the corresponding hydrazides 7a‐d. Treatment of 8 with triethylamine and morpholine afforded the tetrazines 10 and the amidrazones 11 respectively. Acid hydrolysis of 11 yielded the hydrazides 7. Reaction of 8 with phenylhydrazine gave 3,5‐diaryltetrazoles 14. However, reaction of 8 with aroylhyrazines yielded 3,5‐diaryl‐4‐β‐naphthalenesulfonylamino‐4H‐1,2,4‐triazoles 15. The structures of the products were assigned upon the basis of their spectra, elemental analyses and alternate synthesis whereever possible.
A practical synthesis of 1,3,4,14b‐tetrahydro‐2‐methyl‐10H‐pyrazino‐[1,2‐a]pyrrolo[2,1‐c][1,4]benzodiazepine (1:1) maleate
Authors: Boyer S. K. , Fitchett G. , Wasley J. W. F. , Zaunius G. 
Published: April 2009

AbstractA practical synthesis of the anti‐depressant, 1,3,4,14b‐tetrahydro‐2‐methyl‐10H‐pyrazino[1,2‐a]pyrrolo‐[2,1‐c][1,4]benzodiazepine (1:1) maleate (Aptazapine 10) is reported in seven steps and approximately 20% overall yield. The key step of the synthesis was the formation of the tricyclic intermediate methyl 10,11‐dihydro‐5H‐pyrrolo[2,1‐c][1,4]benzodiazepine‐11‐carboxylate (7) via a “Pictet‐Spengler” type condensation of o‐aminobenzylpyrrole (6) and methyl glyoxylate or the methoxy hemiacetal thereof.
Mass spectral fragmentation patterns of heterocycles. VII . Reinvestigation of fundamental processes in phenothiazines
Authors: Hallberg Anders , Al‐Showaier Ibrahim , Martin Arnold R. 
Published: April 2009

AbstractElectron impact induced fragmentation patterns of simple phenothiazines have been reinvestigated using metastable ion studies, exact mass measurements and deuterated derivatives. Secondary fragmentation processes involving ions m/e 198, 171, 167, 166, 154, 140 and 139 have been clarified. Mechanisms for the release of sulfur (SH· and CSH·) nitrogen (HCN and H2CN·) containing fragments from phenothiazine molecular ion are proposed based on the deuterium content of the daughter ions obtained from 1,9‐dideutenophenothiazine. A revised mechanism for the expulsion of ketene from 10‐acetylphenothiazine is suggested based on the fragmentation pattern of the 1,9‐dideuterioderivative. The composition of m/e 140 was determined by high resolution measurement to be C10H6N and not C11H7 as previously reported.
Synthesis of some 1,3,8‐trisubstituted pyrimido[4,5‐c][2,7]‐naphthyridin‐6‐ones as potential antitumor agents
Authors: Gangjee Aleem , O'Donnell John K. , Bardos Thomas J. , Kalman Thomas I. 
Published: April 2009

AbstractCondensation of three 2,4‐disubstituted 6‐aminopyrimidines with methyl 1‐benzyl‐4‐oxo‐3‐piperidinecarboxylate afforded, in each case, new tricyclic, angular 1,3,8‐trisubstituted pyrimido[4,5‐c][2,7]naphthyridin‐6‐ones. 2,4,6‐Triaminopyrimidine gave the 7,8,9,10‐tetrahydrocyclo condensed product 5 as anticipated. However, the use of 2‐amino‐4‐oxo‐ or 2,4‐dioxo‐6‐aminopyrimidine afforded the dehydrogenated, 9,10‐dihydrotricyclic products 11 and 12. The growth of leukemia L1210 cells in culture were inhibited 50% by the 1,3‐diamino analog 5 at 2 × 10−6M and by the 1,3‐dioxo analog 12 at 10−5M.
Crystal structure determination of 2′‐nitro‐10‐phenylphenothiazine
Authors: Jovanovic Misa V. , Biehl Edward R. , De Meester Patrice , Chu Shirley S. C. 
Published: April 2009

AbstractThe structure of the titled compound, 4, has been solved by x‐ray analysis. One of the important structural features of 4 is that the 2′‐nitrophenyl group is in the plane bisecting the phenothiazine ring which is in contrast to that of 10‐(2′‐pyrazyl)phenothiazine of 4′‐nitro‐10‐phenylphenothiazine in which the 10‐aryl group is perpendicular to the plane bisecting the phenothiazine ring. The structure of 4 is in agreement with its 1H and 13C nmr data which indicate that resonance interactions between the 2′‐nitrophenyl group and the lone pair of electrons on N10 are hindered sterically by the 2′‐nitro group.
The preparation of new chiral diphenyl‐substituted macrocyclic polyether‐diester compounds and their enantiomeric recognition of chiral organic ammonium salts
Authors: Bradshaw Jerald S. , Thompson Patricia K. , Izatt Reed M. , Morin Frederick G. , Grant David M. 
Published: April 2009

AbstractA series of chiral diphenyl‐substituted macrocyclic polyether‐diester ligands have been prepared from the chiral diphenyl‐substituted tetraethylene glycol. Enantiomeric recogntion by the chiral diphenyl‐substituted pyridino‐diester‐18‐crown‐6 compound (7) was studied by temperature dependent 1H NMR spectroscopy in deuteriodichloromethane. This ligand exhibited chiral recognition when complexed with the hydrogen per‐chlorate salts of (R)‐ and (S)‐α‐(1‐naphthyl)ethylamine and (R)‐ and (S)‐methyl phenylalaninate.
Synthesis and some reactions of 7‐methyl‐5‐phenyl‐5H‐pyrazolo[3,4‐e]1,2,4‐triazine‐3‐thiol
Authors: Youssef Mohamed Salah Kamel , Atta Ferial Mohamed , Hassan Khairy Mohamed , Abbady Mohamed Saad 
Published: April 2009

AbstractThe title compound II has been prepared by the reaction of 3‐methyl‐1‐phenyl‐4‐oxo‐5‐pyrazolone with thiosemicarbazide in aqueous potassium carbonate. Alkylation of II on the sulfur atom in aqueous sodium hydroxide afforded the 3‐alkylthio derivatives III. Interaction of II or III with different amines yielded the 3‐amino derivatives IV. The 3‐hydrazino derivative IVa condensed with aromatic aldehydes in ethanol or acetic acid giving the corresponding hydrazones V.
Synthesis of 17β‐acetamido‐3‐aza‐A‐homo‐4α‐androsten‐4‐one
Authors: Athanasiou Catherine , Catsoulacos Panayotis 
Published: April 2009

AbstractA synthetic approach for the preparation of 17β‐acetamido‐3‐aza‐A‐homo‐4α‐androsten‐4‐one is described.
Reactivity of a tetrahedral intermediate in hydrolysis of N‐acetylpyrrole
Authors: Cipiciani Antonio , Savelli Gianfranco , Bunton Clifford A. 
Published: April 2009

AbstractBase hydrolysis of N‐acetylpyrrole (1a) involves formation of an anionic tetrahedral intermediate (2a). The equilibrium constant between these two species can be estimated by extrapolation based on the equilibrium constants for hydration of N‐trichloroacetyl‐ and N‐trifluoroacetylpyrrole and the estimated pKa for deprotonation of the hydrates of these compounds. Inductive effects upon hydration and deprotonation of the hydrates were estimated by analogy with inductive effects upon the equilibrium reactions of chloral and acetaldehyde. The free energies of activation for formation and return of 2a are approximately 16 and 12.5 Kcal mole−1 respectively and for conversion of 2a to products 11 Kcal mole−1 in aqueous 1M OH−.
Addition reactions of thiophenols with dihydro‐ and tetrahydropyridinecarbonitriles. A comparison with reactions of phenols
Authors: Butt Graeme L. , Deady Leslie W. 
Published: April 2009

Abstractp‐Chlorothiophenol reacts with 1‐methyl‐1,2,5,6‐tetrahydropyridine‐X‐carbonitriles (1, X = 4, 6, X = 3) and with 1‐methyl‐1,Y‐dihydropyridine‐3‐carbonitrile (7, Y = 6, 8, Y = 4) to give the anticipated addition products. Geometric isomers were formed from 6, but not from 1, and the stereochemistry of the products has been determined. The chemistry of the reactions with p‐cresol was quite different. No reaction occurred with 6 or 7, while 8 gave a 6‐(2‐hydroxy‐5‐methylphenyl)‐ derivative, analogous to the unexpected product obtained previously from 1.