bluuebunny/crossref_metadata_2025_split huggingface dataset:
Topical Calcipotriol Plus 5-Fluorouracil in the Treatment of Actinic Keratosis, Bowen’s Disease, and Squamous Cell Carcinoma: A Systematic Review
Authors: Lapidus Adam H. , Lee Sangho , Liu Zhao Feng , Smithson Sarah , Chew Christopher Y. , Gin Douglas 
Published: May 2024

Background/Objectives: Actinic keratoses (AK) are premalignant skin lesions caused by chronic sun exposure, topically managed by 5-fluorouracil (5-FU), diclofenac 3% gel, and imiquimod. Despite their effectiveness, long treatment duration and severe adverse local skin reactions have limited patient concordance. Calcipotriol has recently been used as a combination agent for existing topical AK treatments. A systematic review was performed to determine the clinical efficacy of 5-FU and calcipotriol for the treatment of AK, Bowen’s disease, and squamous cell carcinoma (SCC). Methods: A systematic literature search was conducted on Medline, Embase, and Cochrane Library. Among the 84 records screened, 12 were retrieved for full-text review and 8 were included in the final analysis. Results: Among the 8 studies, there were 214 control patients and 288 patients who received the intervention. The combination 5% 5-FU with calcipotriol resulted in a significant reduction in the number of AKs on the face, scalp, right upper extremity, and left upper extremity for all sites at 8 weeks ( P < .0001). No significant difference in SCC incidence was observed at 1 or 2 years, but there was a significant reduction observed at 3 years for SCC on face and scalp. No study assessed the combination for Bowen’s disease. Conclusions: Combination 5% 5-FU with calcipotriol is an effective treatment for Aks; however, future trials may consider longer treatment and follow-up periods for the treatment and prevention of AK, SCC in situ, and SCC.
Exploring the roles of openness to experience, emotions, and proficiency levels in bilingual students’ happiness
Authors: Chen Xinjie , He Jinbo , Cai Zhihui 
Published: May 2024

Aims and objectives:Limited attention has been paid to whether and how bilinguals’ multiple language status is related to their well-being. Thus, this research aims to explore whether and how bilingual proficiency interacts with the relationships between personality, emotions, and happiness in bilinguals.Methodology:This study employed a survey questionnaire approach.Data and analysis:A sample of 277 bilingual college students in the United States participated in the project. Mediation and moderation analyses were conducted.Findings and conclusion:Results suggested that positive emotion fully mediated the relationship between openness to experience and happiness, and bilingual proficiency moderated the relationship between openness to experience and emotions.Originality:This study unpacked the link between openness to experience and happiness through mediators of different emotions. Importantly, this study highlighted the different moderating impacts of bilingual proficiency on the relationship between openness to experience and emotions.Implications:This study presents several implications related to positive language education practices.
Interactions between physical activity and psychological factors in the association with the risk of lean type 2 diabetes mellitus
Authors: Baik Inkyung 
Published: May 2024

Background: The extent to which physical activity and psychological factors may affect the risk of diabetes mellitus among lean individuals remains unclear. Purpose: This study aimed to investigate the associations of total physical activity (TPA) and psychological factors with lean type 2 diabetes mellitus (T2DM) risk. Research Design: A prospective cohort study. Study Sample: The study population included 1,945 Korean adults who maintained a body mass index <23 kg/m2. Data Collection and Analysis: Baseline data on TPA and psychological factors were collected and T2DM incidence was assessed for 10 years. For analysis, a multivariable Cox proportional hazards regression model was used. Results: TPA was inversely associated with T2DM risk and this association was more pronounced in participants who were depressed or distressed; the top TPA quartile exhibited significant reductions in T2DM risk of 66% (95% confidence interval [CI]: 0.15, 0.78) and 65% (95% CI: 0.14, 0.88) among participants who reported depressed mood and those who perceived high distress, respectively, compared with the bottom TPA quartile. Conclusions: The current study demonstrated the preventive effects of physical activity on T2DM in lean adults through its interaction with psychological factors.
Assessment of the Quality of Patient-Oriented Internet Information on Fluorescence Imaging in Surgery
Authors: Khalid Aizaz , Anuff Heena , Woodhead Sophie , Yeung Trevor M. 
Published: May 2024

Background In the digital age, patients are increasingly turning to the Internet to seek medical information to aid in their decision-making process before undergoing medical treatments. Fluorescence imaging is an emerging technological tool that holds promise in enhancing intra-operative decision-making during surgical procedures. This study aims to evaluate the quality of patient information available online regarding fluorescence imaging in surgery and assesses whether it adequately supports informed decision-making. Method The term “patient information on fluorescence imaging in surgery” was searched on Google. The websites that fulfilled the inclusion criteria were assessed using 2 scoring instruments. DISCERN was used to evaluate the reliability of consumer health information. QUEST was used to assess authorship, tone, conflict of interest and complementarity. Results Out of the 50 websites identified from the initial search, 10 fulfilled the inclusion criteria. Only two of these websites were updated in the last two years. The definition of fluorescence imaging was stated in only 50% of the websites. Although all websites mentioned the benefits of fluorescence imaging, none mentioned potential risks. Assessment by DISCERN showed that 30% of the websites were rated low and 70% were rated moderate. With QUEST, the websites demonstrated an average score of 62.5%. Conclusion This study highlights the importance of providing patients with accurate and balanced information about medical technologies and procedures they may undergo. Fluorescence imaging in surgery is a promising technology that can potentially improve surgical outcomes. However, patients need to be well-informed about its benefits and limitations in order to make informed decisions about their healthcare.
Inpatient Corridor Visibility and Care Team Communication
Authors: Zook Julie , Culpeper Rachel , Worley Jennifer , Miller Chase 
Published: May 2024

Objective: This article aims to investigate the impact of fine-grained differences in unit layout on care staff corridor communication. Background: Corridor design can be undertaken with greater emphasis on space and cost efficiency or with greater emphasis on affording quality knowledge workspace. Building on prior research on care team communication and inpatient unit design, this study aims to gain a better understanding of how corridor layout properties affect care team communication. Method: This study used space syntax analysis to characterize inpatient unit design, specifically floor-plan layout. Two approaches were used to capture care team communication: behavior mapping with recording of care team member locations and whether they were communicating and the HDR CARE Scale, Inpatient Version. The two units were part of a vertical tower expansion project, and, though constructed at separate times, they maintain the same organizational culture, floor plate, and location of key vertical elements. Results: The newer unit was found to be more visually open using three measures from space syntax. More nursing staff verbal communication was observed on this unit. Across both units, nursing staff were more likely to be observed verbally communicating in locations that were more visually connected (i.e., at locations with larger viewsheds). There were no significant differences between nursing staff self-report on work using the HDR CARE Scale, Inpatient Version. Conclusion: We conclude that care team communication may tend to be encouraged by visual connectivity that can be promoted through floor-plan layout.
Melanoma identification and classification model based on fine-tuned convolutional neural network
Authors: Almufareh Maram F , Tariq Noshina , Humayun Mamoona , Khan Farrukh Aslam 
Published: May 2024

BackgroundBreakthroughs in skin cancer diagnostics have resulted from recent image recognition and Artificial Intelligence (AI) technology advancements. There has been growing recognition that skin cancer can be lethal to humans. For instance, melanoma is the most unpredictable and terrible form of skin cancer.Materials and MethodologyThis paper aims to support Internet of Medical Things (IoMT) applications by developing a robust image classification model for the early detection of melanoma, a deadly skin cancer. It presents a novel approach to melanoma detection using a Convolutional Neural Network (CNN)-based method that employs image classification techniques based on Deep Learning (DL). We analyze dermatoscopic images from publicly available datasets, including DermIS, DermQuest, DermIS&Quest, and ISIC2019. Our model applies convolutional and pooling layers to extract meaningful features, followed by fully connected layers for classification.ResultsThe proposed CNN model achieves high accuracy demonstrates the model’s effectiveness in distinguishing between malignant and benign skin lesions. We developed deep features and used transfer learning to improve the categorization accuracy of medical images. Soft-max classification layer and support vector machine have been used to assess the classification performance of deep features. The proposed model’s efficacy is rigorously evaluated using benchmark datasets: DermIS, DermQuest, and ISIC2019, having 621, 1233, and 25000 images, respectively. Its performance is compared to current best practices showing an average of 5% improved detection accuracy in DermIS, 6% improvement in DermQuest, and 0.81% in ISIC2019 datasets.ConclusionOur study showcases the potential of CNN in melanoma detection, contributing to early diagnosis and improved patient outcomes. The developed model proves its capability to aid dermatologists in accurate decision-making, paving the way for enhanced skin cancer diagnosis.
Language adaptations of mental health interventions: User interaction comparisons with an AI-enabled conversational agent (Wysa) in English and Spanish
Authors: Dinesh Dyuthi Nirupama , Rao M Namrata , Sinha Chaitali 
Published: May 2024

Background In recent times, digital mental health interventions (DMHIs) have been proven to be efficacious; however, most are available only for English speakers, leaving limited options for non-English languages like Spanish. Research shows that mental health services in one's dominant language show better outcomes. Conversational agents (CAs) offer promise in supporting mental health in non-English populations. This study compared a culturally adapted version of an artificial intelligence (AI)-led mental health app, called Wysa, in Spanish and English. Objectives To compare user engagement patterns on Wysa-Spanish and Wysa-English and to understand expressions of distress and preferred language in both versions of Wysa. Methods We adopted a cross-sectional retrospective exploratory design with mixed methods, analyzing users from 10 Spanish-speaking countries between 1 February and 1 August 2022. A quantitative sample A (n = 2767) was used for descriptive statistics, including user engagement metrics with a Wilcoxon test. A subset qualitative sample B (n = 338) was examined for word count differences based on valence, and a content analysis was conducted to examine idioms of distress. Results Compared to Wysa-English, Wysa-Spanish had more sessions ( P < .001, d = 0.18) and a greater volume of disclosure of distress. In Wysa-Spanish, the average length of a conversation was significantly longer than in Wysa-English ( P < .001, d = 0.44). Users preferred interventions with free text responses (“Thought recording”) in Spanish ( P < .01, d = 0.41), and Spanish messages were significantly longer ( P < .01, d = 0.24). Wysa-Spanish saw more frequent expressions of negative emotions and feelings of self-harm and suicide. Conclusion Given the high engagement within the Spanish version of Wysa, the findings demonstrate the need for culturally adapted DMHIs among non-English populations, emphasizing the importance of considering linguistic and cultural differences in the development of DMHIs to improve accessibility for diverse populations.
Comparative outcome of different treatment options for acetabulum fractures in elderly individuals—a retrospective analysis of 207 patients
Authors: Husi Sebastian , Vach Werner , Cadosch Dieter , Jakob Marcel , Saxer Franziska , Eckardt Henrik 
Published: May 2024

Purpose Acetabular fractures are challenging injuries in the heterogeneous population of elderly patients. In patients able to partially bear weight, open reduction and internal fixation (ORIF) is indicated. In frail patients, ORIF combined with primary total hip arthroplasty (THA) allows early weight-bearing to preserve independence. This article systematically analyses a treatment algorithm that separates fractures into stable fractures treated conservatively and fractures needing surgical stabilization with osteosynthesis or osteosynthesis plus arthroplasty, dependent on patient characteristics but less on the fracture classification or energetic impact of the trauma. Methods Data on patients ≥50 years of age treated for acetabular fractures (2009–2019) were retrospectively analyzed. The primary outcome was loss of independence. In-hospital complications, length of stay, re-operations, the need for walking aids, and pain were analyzed as secondary outcomes. Results Out of 207 patients, 135 were male, average age was 70 years. Eighty-five patients were treated conservatively, 89 ORIF, and 33 ORIF plus arthroplasty in one operation. The initial morbidity of patients treated with the combined operation was higher than osteosynthesis alone, but the long-term outcome was favorable with less pain and fewer secondary interventions. Age and female gender were associated with the decision to treat the fracture with the combination of osteosynthesis and arthroplasty. Conclusions The results suggest that aged and potentially frail patients with acetabular fracture have better long-term outcome after ORIF combined with arthroplasty at the price of an initially higher risk of adverse outcomes. Females were more frequently treated with the combined operation independent of other risk factors
Kobellite homologues from the Boliden Au–Cu–(As) deposit, Sweden: jigsaw patterning via nanoscale intergrowths in chessboard structures
Authors: Ciobanu Cristiana L. , Slattery Ashley D. , Cook Nigel J. , Wade Benjamin P. , Ehrig Kathy , Wagner Thomas , Liu Wenyuan 
Published: May 2024

AbstractSulfosalt assemblages in a specimen from the Boliden Au–Cu–(As) deposit in northern Sweden, comprise micrometre to nanometre scale intergrowths of Se-rich izoklakeite and tintinaite with average formulae and calculated homologue number (N) given as: (Cu1.88Fe0.18)2.06(Pb22.92Ag1.47Cd0.01Zn0.01)24.41(Sb13.12Bi8.69)21.8(S50.19Se6.43Te0.12)56.73,N = 3.83, and (Cu1.31Fe0.74)2.05(Pb10.58Ag0.18Cd0.05Zn0.02)10.83(Sb10.2Bi5.23)15.43(S32.22Se2.46)34.7, N = 2.05, respectively. Tintinaite coexists with (Bi, Se)-rich jamesonite. High-angle annular dark field scanning transmission electron microscopy (HAADF STEM) imaging reveals chessboard structures comprising PbS and SnS modules with the number of atoms in the octahedral (M) sites counted as: n1 = 18 and n2 = 8 for tintinaite and n1 = 30 and n2 = 16 for izoklakeite. The homologue number can be calculated using the formula: N = (n1/6)–1 and N = n2/4 for PbS and SnS modules giving NTti = 2 and NIz = 4. A new N = 3 homologue, defined by n = 12 and n = 24 SnS and PbS modules, respectively, is identified as single or double units within areas with intergrowths between kobellite and izoklakeite. HAADF STEM imaging also reveals features attributable to lone electron pair micelles within the Sb-rich kobellite homologues. Atomic-resolution EDS STEM chemical mapping of Pb–Bi–Sb-sulfosalts shows a correlation with crystal structural modularity. The maps also highlight sites in the SnS modules of tintinaite in which Sb > Bi. Coherent nanoscale intergrowths between tintinaite and izoklakeite define jigsaw patterns evolving from chessboard structures and are considered to have formed during co-crystallisation of the two phases. Displacement textures and crosscutting veinlets (a few nm in width) are interpreted as evidence for superimposed syn-metamorphic deformation and are associated with the redistribution of Bi and Se. Imaging and mapping using HAADF STEM techniques is well suited to characterisation of Pb–Sb–Bi-sulfosalt phases, offering largely untapped potential to unravel the evolution of chessboard structures with applications across mineralogy but also extending into allied fields.
Bortezomib restrains M2 polarization and reduces CXCL16-associated CXCR6+CD4 T cell chemotaxis in bleomycin-induced pulmonary fibrosis
Authors: Zhou Ting , lin Lan , Zhan Yawen , Zhang Ziyao , Jiang Ying , Wu Mi , Xue Dan , Chen Limin , Weng Xiufang , Huang Zhenghui 
Published: May 2024

Abstract
Background
The development of pulmonary fibrosis involves a cascade of events, in which inflammation mediated by immune cells plays a pivotal role. Chemotherapeutic drugs have been shown to have dual effects on fibrosis, with bleomycin exacerbating pulmonary fibrosis and bortezomib alleviating tissue fibrotic processes. Understanding the intricate interplay between chemotherapeutic drugs, immune responses, and pulmonary fibrosis is likely to serve as the foundation for crafting tailored therapeutic strategies.

Methods
A model of bleomycin-induced pulmonary fibrosis was established, followed by treatment with bortezomib. Tissue samples were collected for analysis of immune cell subsets and functional assessment by flow cytometry and in vitro cell experiments. Additionally, multi-omics analysis was conducted to further elucidate the expression of chemokines and chemokine receptors, as well as the characteristics of cell populations.

Results
Here, we observed that the expression of CXCL16 and CXCR6 was elevated in the lung tissue of a pulmonary fibrosis model. In the context of pulmonary fibrosis or TGF-β1 stimulation in vitro, macrophages exhibited an M2-polarized phenotype and secreted more CXCL16 than those of the control group. Moreover, flow cytometry revealed increased expression levels of CD69 and CXCR6 in pulmonary CD4 T cells during fibrosis progression. The administration of bortezomib alleviated bleomycin-induced pulmonary fibrosis, accompanied by reduced ratio of M2-polarized macrophages and decreased accumulation of CD4 T cells expressing CXCR6.

Conclusions
Our findings provide insights into the key immune players involved in bleomycin-induced pulmonary fibrosis and offer preclinical evidence supporting the repurposing strategy and combination approaches to reduce lung fibrosis.
How long do transport infrastructure last: evidences from Norwegian roads and rail network
Authors: Tveter Eivind , Tomasgard Tore 
Published: May 2024

AbstractHow long will transport infrastructure generate benefits for the society (the appraisal period) is an essential assumption in transport appraisals. However, there are considerable differences in the recommended appraisal periods used in cost–benefit analysis between countries. In this paper, we therefore examine how long transport infrastructure was used in the past before it was replaced, closed, or substantially improved. We label this period the ex-post appraisal period. The study considers rail and roads in Norway and analyses how long they were used using the statistical technique survival analysis. The results show that motorways build in the 1960s was used around 40 years before being upgraded, while most of railroad infrastructure have lasted more than 100 years. If these results are applicable for the future use it may indicate that the use of long appraisal periods (more than 50 years) in some countries could be optimistic for roads and rather conservative for railroads.
The modular architecture of sigma factors in cyanobacteria: a framework to assess their diversity and understand their evolution
Authors: Gevin Marine , Latifi Amel , Talla Emmanuel 
Published: May 2024

Abstract
Background
Bacterial RNA polymerase holoenzyme requires sigma70 factors to start transcription by identifying promoter elements. Cyanobacteria possess multiple sigma70 factors to adapt to a wide variety of ecological niches. These factors are grouped into two categories: primary sigma factor initiates transcription of housekeeping genes during normal growth conditions, while alternative sigma factors initiate transcription of specific genes under particular conditions. However, the present classification does not consider the modular organization of their structural domains, introducing therefore multiple functional and structural biases. A comprehensive analysis of this protein family in cyanobacteria is needed to address these limitations.

Results
We investigated the structure and evolution of sigma70 factors in cyanobacteria, analyzing their modular architecture and variation among unicellular, filamentous, and heterocyst-forming morphotypes. 4,193 sigma70 homologs were found with 59 distinct modular patterns, including six essential and 29 accessory domains, such as DUF6596. 90% of cyanobacteria typically have 5 to 17 sigma70 homologs and this number likely depends on the strain morphotype, the taxonomic order and the genome size. We classified sigma70 factors into 12 clans and 36 families. According to taxonomic orders and phenotypic traits, the number of homologs within the 14 main families was variable, with the A.1 family including the primary sigma factor since this family was found in all cyanobacterial species. The A.1, A.5, C.1, E.1, J.1, and K.1 families were found to be key sigma families that distinguish heterocyst-forming strains. To explain the diversification and evolution of sigma70, we propose an evolutionary scenario rooted in the diversification of a common ancestor of the A1 family. This scenario is characterized by evolutionary events including domain losses, gains, insertions, and modifications. The high occurrence of the DUF6596 domain in bacterial sigma70 proteins, and its association with the highest prevalence observed in Actinobacteria, suggests that this domain might be important for sigma70 function. It also implies that the domain could have emerged in Actinobacteria and been transferred through horizontal gene transfer.

Conclusion
Our analysis provides detailed insights into the modular domain architecture of sigma70, introducing a novel robust classification. It also proposes an evolutionary scenario explaining their diversity across different taxonomical orders.