bluuebunny/crossref_metadata_2025_split huggingface dataset:
First successful downhole testing of the permeability logging prototype
Authors: Li Ning , Wang Kewen , Lu Junqiang , Liu Peng , Xiao Chengwen , Wu Hongliang , Guo Qingbin , Fan Huajun , Men Baiyong , Feng Zhou , Li Yusheng 
Published: June 2024

Abstract
This article reports on the successful downhole testing of the prototype permeability logging instrument, developed by the Li Ning Innovation Team of PetroChina. The test was carried out on 3 March 2024 in the Ren 91 standard well in Huabei (North China). In this article, we analysed the instrument characteristics of porosity logging measurement, saturation logging measurement, and permeability logging measurement in three stages of development, as well as the current research status of continuous depth-permeability measurement in the wellbore formations. We highlighted the basic principle of permeability logging measurement with Stoneley waves and pointed out the main challenges in the development of permeability logging measurement devices and on-site application research.
Anatomical and Surface Electron Microscopic Investigation of the Tongue and Laryngeal Prominence in the Red-Eyed Turtle Dove (Streptopelia semitorquata, Rüppel 1837)
Authors: Igbokwe Casmir Onwuaso , Mbajiorgu Felix Ejikeme , Bello Umar Muhammed 
Published: June 2024

Abstract
This study investigated the morphology of tongue and laryngeal structures in red-eyed dove and related it to feeding habits. Samples were examined using gross anatomy, scanning electron microscopy (SEM), and histological techniques. The tongue conformed to the shape of the lower beak, and the apex with a pointed tip, body, and root were distinguished. A median grove was apparent, and a papillary crest with pointed triangular papillae separated the body from the root. The length of the tongue, its width (body), and the percentage of the length of the lower jaw occupied by the tongue were, on average, 12.5 mm, 2.3 mm, and 57.3%, respectively. SEM showed highly desquamated dorsal epithelium with pointed papillae-like projections. The papillary crest presented pointed papillae of about 20–22. Salivary openings were apparent in the root, surrounded by mucosal folds and blunt papillae. Laryngeal prominence was irregularly triangular shaped and elevated. The rim of the glottis showed glandular pinpointed marks. Typical cornified multilayered mucosal epithelium was present in the apex and decreased caudally. Hyaline entoglossal cartilage and adjoining connective tissue were present in the body and apex. Numerous tubuloalveolar glands were seen in the body and root. The rim of the glottis showed mucous intraepithelial glands. The rostral and caudal lingual glands indicated positive reaction to neutral and acidic mucins. This study demonstrated a morphofunctional relationship of the tongue of a red-eyed dove to its diet.
Evidence for non-zero turbulence in the protoplanetary disc around IM Lup
Authors: Flaherty Kevin , Hughes A Meredith , Simon Jacob B , Reina Alicia Smith , Qi Chunhua , Bai Xue-Ning , Andrews Sean M , Wilner David J , Kóspál Ágnes 
Published: June 2024

ABSTRACT
The amount of turbulence in protoplanetary discs around young stars is critical for determining the efficiency, timeline, and outcomes of planet formation. It is also difficult to measure. Observations are still limited, but direct measurements of the non-thermal, turbulent gas motion are possible with the Atacama Large Millimeter/submillimeter Array (ALMA). Using CO(2–1)/$^{13}$CO(2–1)/C$^{18}$O(2–1) ALMA observations of the disc around IM Lup at $\sim 0.4$ arcsec ($\sim$60 au) resolution we find evidence of significant turbulence, at the level of $\delta v_{\rm turb}=(0.18-0.30)$c$_\mathrm{ s}$. This result is robust against systematic uncertainties (e.g. amplitude flux calibration, mid-plane gas temperature, disc self-gravity). We find that gravito-turbulence as the source of the gas motion is unlikely based on the lack of an imprint on the rotation curve from a massive disc, while magneto-rotational instabilities and hydrodynamic instabilities are still possible, depending on the unknown magnetic field strength and the cooling time-scale in the outer disc.
Automated detection and analysis of coronal active region structures across solar cycle 24
Authors: Gass Daniel G , Walsh Robert W 
Published: June 2024

ABSTRACT
Observations from NASA’s Solar Dynamic Observatory Atmospheric Imaging Assembly were employed to investigate targeted physical properties of coronal active region structures across the majority of solar cycle 24 (From 2010 May to end of 2020 December). This is the largest consistent study to date which analyses emergent trends in structural width, location, and occurrence rate by performing an automatic and long-term examination of observable coronal and chromospheric limb features within equatorial active region belts across four extreme ultraviolet wavelengths (171, 193, 211, and 304 Å). This has resulted in over 30 000 observed coronal structures and hence allows for the production of spatial and temporal distributions focused upon the rise, peak, and decay activity phases of solar cycle 24. Employing a self-organized-criticality approach as a descriptor of coronal structure formation, power-law slopes of structural widths versus frequency are determined, ranging from -1.6 to -3.3 with variations of up to 0.7 found between differing periods of the solar cycle, compared to a predicted Fractal Diffusive Self-Organized Criticality (FD-SOC) value of -1.5. The North–South hemispheric asymmetry of these structures was also examined with the Northern hemisphere exhibiting activity that is peaking earlier and decaying slower than the Southern hemisphere, with a characteristic ‘butterfly’ pattern of coronal structures detected. This represents the first survey of coronal structures performed across an entire solar cycle, demonstrating new techniques available to examine the composition of the corona by latitude in varying wavelengths.
Exploring galaxy evolution time-scales in clusters: insights from the projected phase space
Authors: Sampaio V M , de Carvalho R R , Aragón-Salamanca A , Merrifield M R , Ferreras I , Cornwell D J 
Published: June 2024

ABSTRACT
Galaxies infalling into clusters undergo both star formation quenching and morphological transformation due to environmental effects. We investigate these processes and their time-scales using a local sample of 20 191 cluster and 11 674 field galaxies from Sloan Digital Sky Survey. By analysing morphology as a function of distance from the star formation main sequence, we show that environmental influence is especially pronounced for low-mass galaxies, which emerge from the green valley (GV) with early-type morphologies before their star formation is fully suppressed. Using the galaxies’ positions in the clusters’ projected phase space, we examine the evolution of blue cloud, GV, and red-sequence fractions as a function of time since infall. Interestingly, the GV fraction remains constant with time since infall, suggesting a balanced flow of galaxies in and out of this class. We estimate that galaxies less massive than $10^{10}\,\rm {\rm M}_{\odot }$ spend approximately 0.4 Gyr in the GV. By comparing quenched and early-type populations, we provide further evidence for the ‘slow-then-rapid’ quenching model and suggest that it can also be applied to morphological transitions. Our results indicate that morphological transformation occurs at larger radii than complete star formation quenching. About 75 per cent of galaxies undergoing morphological transition in clusters are spirals evolving into S0s, suggesting that infalling galaxies retain their discs, while massive ellipticals are relics of early merger events. Finally, we show it takes approximately 2.5 and 1.2 Gyr after the delay time ($\sim 3.8 {\,\rm Gyr}$) for the population of low-mass galaxies in clusters to reach a 50 per cent threshold in quenched and early-type fraction, respectively. These findings suggest morphological transition precedes full star formation quenching, with both processes possibly being causally linked.
Chrononutrition in Critical Illness
Authors: Sagun Eylul , Akyol Asli , Kaymak Cetin 
Published: June 2024

Abstract
Circadian rhythms in humans are biological rhythms that regulate various physiological processes within a 24-hour time frame. Critical illness can disrupt the circadian rhythm, as can environmental and clinical factors, including altered light exposure, organ replacement therapies, disrupted sleep–wake cycles, noise, continuous enteral feeding, immobility, and therapeutic interventions. Nonpharmacological interventions, controlling the ICU environment, and pharmacological treatments are among the treatment strategies for circadian disruption. Nutrition establishes biological rhythms in metabolically active peripheral tissues and organs through appropriate synchronization with endocrine signals. Therefore, adhering to a feeding schedule based on the biological clock, a concept known as “chrononutrition,” appears to be vitally important for regulating peripheral clocks. Chrononutritional approaches, such as intermittent enteral feeding that includes overnight fasting and consideration of macronutrient composition in enteral solutions, could potentially restore circadian health by resetting peripheral clocks. However, due to the lack of evidence, further studies on the effect of chrononutrition on clinical outcomes in critical illness are needed. The purpose of this review was to discuss the role of chrononutrition in regulating biological rhythms in critical illness, and its impact on clinical outcomes.
Get2PrEP2—A Provider Messaging Strategy to Improve PrEP Uptake: A Randomized Controlled Quality Improvement Project
Authors: Zucker Jason , Castor Delivette , Theodore Deborah , Carnevale Caroline , Osilama Eshiemomoh , Archer Norman , Bonadonna Lily , Wadden Elena , Morley Nicholas , Huang Simian , Meyers Kathrine , Cohall Alwyn , Gordon Peter , Sobieszczyk Magdalena E 
Published: June 2024

Abstract

Introduction
HIV preexposure prophylaxis (PrEP), a key strategy for preventing HIV transmission, requires awareness and access to PrEP services. Although all patients should be made aware of HIV PrEP; the diagnosis of bacterial sexually transmitted infections (STIs) is an important indicator of potential HIV PrEP need. In a previous evaluation of Get2PrEP (G2P), we found that an electronic medical record laboratory comments did not increase the frequency of PrEP discussions between patients and providers. In Get2PrEP2 (G2P2), we hypothesized that active, personalized messaging to providers about HIV PrEP would increase the documentation of PrEP discussions, referrals, and/or provision of HIV PrEP to individuals diagnosed with an STI.

Methods
G2P2 was a parallel 3-arm, unblinded, randomized controlled design. Participants were allocated 2:1 to intervention or control. Participants in the intervention arm were further allocated to receive provider messaging through the electronic medical record chat message or e-mail.

Results
The 191 randomized encounters resulted in a modest 7.8% (odds ratio, 1.078; confidence interval, 1.02–1.13) increase in documented PrEP discussions in intervention encounters versus none in the standard care group. There was no statistical difference by intervention modality. All documented discussions occurred in the outpatient or emergency department and were more frequent in women and those aged &lt;25 years.

Discussion
An e-mail or electronic medical record chat message sent to providers of patients testing positive for an STI had a small but significant effect on documented patient-provider PrEP discussions. Further investigation is required to determine whether provider messaging can increase PrEP uptake among eligible patients and longer-term outcomes.
Bulk Rock and Olivine Chemistry and Isotopes of 106–58 Ma Basalts from Liaodong Peninsula and its Adjacent Areas: Implications for Secular Evolution of the Big Mantle Wedge in Eastern China
Authors: Zhang Chao , Ma Qiang , Hong Lubing , Dai Hong-Kun , Ma Liang , Xu Yigang , Zheng Jianping , Cao Hui-Ying 
Published: June 2024

Abstract
The subducting Pacific slab stagnates in the mantle transition zone and creates a big mantle wedge (BMW) system in East Asia. A similar BMW structure may have already existed since the Early Cretaceous (&gt;120 Ma), but how such a structure evolved from Early Cretaceous to the present day remains unclear. We address this issue by comparing compositions and source heterogeneity of the 106–58 Ma basalts from Liaodong Peninsula and its adjacent areas (LPAA) in eastern China, with those formed in the modern BMW setting. The LPAA basalts display oceanic island basalts–like trace element patterns. Elemental and isotopic compositions of these basalts and their olivine phenocrysts point to peridotite and two recycled components in their source. One recycled component is altered lower oceanic crust given the low δ18Oolivine (2.8–5.2‰) of the ~99 Ma Liaoyuan alkali basalts. The second component consists of altered upper oceanic crust and pelagic sediments indicated by high δ18Oolivine (&gt;6.0‰), represented by the ~58 Ma Luanshishanzi alkali basalts. The depleted mantle-like isotopes of these two components suggest derivation from a young HIMU source with characteristics of the Izanagi plate (e.g. Indian Ocean-type Sr-Nd-Pb-Hf isotopes), which may have resided in the mantle transition zone at that time. Our results reveal strong similarities between chemical and source characteristics of the mantle sampled by the 106–58 Ma LPAA basalts and those derived from the modern BMW. This implies that the BMW structure has been present since the Early Cretaceous, probably having lasted more than 120 Myr, and modulating the chemical properties of the upper mantle and influencing a variety of geological processes.
Automated quantification of wrist bone marrow oedema, pre- and post-treatment, in early rheumatoid arthritis
Authors: Yiu Chungwun , Griffith James Francis , Xiao Fan , Shi Lin , Zhou Bingjing , Wu Su , Tam Lai-Shan 
Published: June 2024

Abstract

Objective
Bone inflammation (osteitis) in early RA (ERA) manifests as bone marrow oedema (BME) and precedes the development of bone erosion. In this prospective, single-centre study, we developed an automated post-processing pipeline for quantifying the severity of wrist BME on T2-weighted fat-suppressed MRI.

Methods
A total of 80 ERA patients [mean age 54 years (s.d. 12), 62 females] were enrolled at baseline and 49 (40 females) after 1 year of treatment. For automated bone segmentation, a framework based on a convolutional neural network (nnU-Net) was trained and validated (5-fold cross-validation) for 15 wrist bone areas at baseline in 60 ERA patients. For BME quantification, BME was identified by Gaussian mixture model clustering and thresholding. BME proportion (%) and relative BME intensity within each bone area were compared with visual semi-quantitative assessment of the RA MRI score (RAMRIS).

Results
For automated wrist bone area segmentation, overall bone Sørensen–Dice similarity coefficient was 0.91 (s.d. 0.02) compared with ground truth manual segmentation. High correlation (Pearson correlation coefficient r = 0.928, P &lt; 0.001) between visual RAMRIS BME and automated BME proportion assessment was found. The automated BME proportion decreased after treatment, correlating highly (r = 0.852, P &lt; 0.001) with reduction in the RAMRIS BME score.

Conclusion
The automated model developed had an excellent segmentation performance and reliable quantification of both the proportion and relative intensity of wrist BME in ERA patients, providing a more objective and efficient alternative to RAMRIS BME scoring.
Data hazards in synthetic biology
Authors: Zelenka Natalie R , Di Cara Nina , Sharma Kieren , Sarvaharman Seeralan , Ghataora Jasdeep S , Parmeggiani Fabio , Nivala Jeff , Abdallah Zahraa S , Marucci Lucia , Gorochowski Thomas E 
Published: June 2024

Abstract
Data science is playing an increasingly important role in the design and analysis of engineered biology. This has been fueled by the development of high-throughput methods like massively parallel reporter assays, data-rich microscopy techniques, computational protein structure prediction and design, and the development of whole-cell models able to generate huge volumes of data. Although the ability to apply data-centric analyses in these contexts is appealing and increasingly simple to do, it comes with potential risks. For example, how might biases in the underlying data affect the validity of a result and what might the environmental impact of large-scale data analyses be? Here, we present a community-developed framework for assessing data hazards to help address these concerns and demonstrate its application to two synthetic biology case studies. We show the diversity of considerations that arise in common types of bioengineering projects and provide some guidelines and mitigating steps. Understanding potential issues and dangers when working with data and proactively addressing them will be essential for ensuring the appropriate use of emerging data-intensive AI methods and help increase the trustworthiness of their applications in synthetic biology.
Privacy versus transparency: It's time to look at the data
Authors: Noseda Filippo 
Published: June 2024

Abstract
In previous articles published in this Review, (‘FATCA, CRS and Public BO registers: a report on the direction of travel—the next 12 months’, 28 Trusts & Trustees (2022), 482–487. https://academic.oup.com/tandt/article/28/6/482/6586702; ‘FATCA and CRS: Recent EU judgment on public BO registers shines a light on the direction of travel’, 29 Trusts & Trustees (2023), 469–474. https://academic.oup.com/tandt/article/29/6/469/7163198) the author argued for a balanced approach to the whole issue of transparency in the area of taxation. The underlying legal analysis touched on data protection and Human Rights legislation, and was supported by eloquent opinions from data protection experts in the European Union. Now it’s time to look at the hard data supporting both sides of the argument.
IXThe Seventeenth Century, Part I
Authors: Martin Catherine Gimelli , Timmis Patrick , Stelzer Emily , Dyck Paul , James Anne , Urban David V 
Published: June 2024

Abstract
This chapter has seven sections: 1. General; 2. Bacon; 3. Browne; 4. Burton; 5. Herbert; 6. Donne; 7. Milton. Sections 1 and 2 are by Catherine Gimelli Martin; section 3 is by Patrick Timmis; section 4 is by Emily Stelzer; section 5 is by Paul Dyck; section 6 is by Anne James; section 7 is by David V. Urban.
Reshaping the Primary Cell Wall: Dual Effects on Plant Resistance to Ralstonia solanacearum and Heat Stress Response
Authors: Desaint Henri , Gigli Alessandro , Belny Adrien , Cassan-Wang Hua , Martinez Yves , Vailleau Fabienne , Mounet Fabien , Vernhettes Samantha , Berthomé Richard , Marchetti Marta 
Published: June 2024

Temperature elevation drastically affects plant defense responses to Ralstonia solanacearum and inhibits the major source of resistance in Arabidopsis thaliana, which is mediated by the receptor pair RRS1-R/RPS4. In this study, we refined a previous genome-wide association (GWA) mapping analysis by using a local score approach and detected the primary cell wall CESA3 gene as a major gene involved in plant response to R. solanacearum at both 27°C and an elevated temperature, 30°C. We functionally validated CESA3 as a susceptibility gene involved in resistance to R. solanacearum at both 27 and 30°C through a reverse genetic approach. We provide evidence that the cesa3mre1 mutant enhances resistance to bacterial disease and that resistance is associated with an alteration of root cell morphology conserved at elevated temperatures. However, even by forcing the entry of the bacterium to bypass the primary cell wall barrier, the cesa3mre1 mutant still showed enhanced resistance to R. solanacearum with delayed onset of bacterial wilt symptoms. We demonstrated that the cesa3mre1 mutant had constitutive expression of the defense-related gene VSP1, which is upregulated at elevated temperatures, and that during infection, its expression level is maintained higher than in the wild-type Col-0. In conclusion, this study reveals that alteration of the primary cell wall by mutating the cellulose synthase subunit CESA3 contributes to enhanced resistance to R. solanacearum, remaining effective under heat stress. We expect that these results will help to identify robust genetic sources of resistance to R. solanacearum in the context of global warming. [Formula: see text] Copyright © 2024 The Author(s). This is an open access article distributed under the CC BY-NC-ND 4.0 International license .
Procyanidin C1 inhibits bleomycin‐induced pulmonary fibrosis in mice by selective clearance of senescent myofibroblasts
Authors: Shao Min , Qiu Yujia , Shen Mengxia , Liu Wei , Feng Dandan , Luo Ziqiang , Zhou Yan 
Published: June 2024

AbstractPulmonary fibrosis is a formidable challenge in chronic and age‐related lung diseases. Myofibroblasts secrete large amounts of extracellular matrix and induce pro‐repair responses during normal wound healing. Successful tissue repair results in termination of myofibroblast activity via apoptosis; however, some myofibroblasts exhibit a senescent phenotype and escape apoptosis, causing over‐repair that is characterized by pathological fibrotic scarring. Therefore, the removal of senescent myofibroblasts using senolytics is an important method for the treatment of pulmonary fibrosis. Procyanidin C1 (PCC1) has recently been discovered as a senolytic compound with very low toxicity and few side effects. This study aimed to determine whether PCC1 could improve lung fibrosis by promoting apoptosis in senescent myofibroblasts and to investigate the mechanisms involved. The results showed that PCC1 attenuates bleomycin (BLM)‐induced pulmonary fibrosis in mice. In addition, we found that PCC1 inhibited extracellular matrix deposition and promoted the apoptosis of senescent myofibroblasts by increasing PUMA expression and activating the BAX signaling pathway. Our findings represent a new method of pulmonary fibrosis management and emphasize the potential of PCC1 as a senotherapeutic agent for the treatment of pulmonary fibrosis, providing hope for patients with pulmonary fibrosis worldwide. Our results advance our understanding of age‐related diseases and highlight the importance of addressing cellular senescence in treatment.
Time to Pregnancy and Life Expectancy: A Cohort Study of 18 796 Pregnant Couples
Authors: Lindahl-Jacobsen R. , Petersson M. Tavlo , Priskorn L. , Skakkebæk N. E. , Juul A. , Kristensen D. M. , Eisenberg M. L. , Jensen T. K. 
Published: June 2024

(Abstracted from Hum Reprod 2024;39(3):595–603)
It is hypothesized that the well-evidenced global decline in reproductive health may, together with behavioral factors, be contributing to the world’s declining fertility and to a soon-expected decreasing global population. Time to pregnancy (TTP), defined as the time to success to conceive under unprotected intercourse, is a commonly used population measure of fecundity, defined as an individual’s capacity to reproduce irrespective of pregnancy intentions.
Maternal and Fetal Safety Outcomes After In Utero Stem Cell Injection: A Systematic Review
Authors: Sagar Rachel L. , Walther-Jallow Lilian , Götherström Cecilia , Westgren Magnus , David Anna L. 
Published: June 2024

(Abstracted from Prenatal Diagnosis 2023;43:1622–1637)
Congenital diseases often have a significant impact on individuals both prenatally and postbirth, and treatment options are quite limited until after delivery. In utero stem cell transplantation (IUSCT) is one method that can be used to treat congenital diseases prenatally, and primarily use hematopoietic or mesenchymal stem cells.