bluuebunny/crossref_metadata_2025_split huggingface dataset:
Microdeletion 9q22.3 syndrome includes metopic craniosynostosis, hydrocephalus, macrosomia, and developmental delay
Authors: Muller Eric A. , Aradhya Swaroop , Atkin Joan F. , Carmany Erin P. , Elliott Alison M. , Chudley Albert E. , Clark Robin D. , Everman David B. , Garner Shannon , Hall Bryan D. , Herman Gail E. , Kivuva Emma , Ramanathan Subhadra , Stevenson David A. , Stockton David W. , Hudgins Louanne 
Published: December 2011

AbstractBasal cell nevus syndrome (BCNS), also known as Gorlin syndrome (OMIM #109400) is a well‐described rare autosomal dominant condition due to haploinsufficiency of PTCH1. With the availability of comparative genomic hybridization arrays, increasing numbers of individuals with microdeletions involving this locus are being identified. We present 10 previously unreported individuals with 9q22.3 deletions that include PTCH1. While 7 of the 10 patients (7 females, 3 males) did not meet strict clinical criteria for BCNS at the time of molecular diagnosis, almost all of the patients were too young to exhibit many of the diagnostic features. A number of the patients exhibited metopic craniosynostosis, severe obstructive hydrocephalus, and macrosomia, which are not typically observed in BCNS. All individuals older than a few months of age also had developmental delays and/or intellectual disability. Only facial features typical of BCNS, except in those with prominent midforeheads secondary to metopic craniosynostosis, were shared among the 10 patients. The deletions in these individuals ranged from 352 kb to 20.5 Mb in size, the largest spanning 9q21.33 through 9q31.2. There was significant overlap of the deleted segments among most of the patients. The smallest common regions shared among the deletions were identified in order to localize putative candidate genes that are potentially responsible for each of the non‐BCNS features. These were a 929 kb region for metopic craniosynostosis, a 1.08 Mb region for obstructive hydrocephalus, and a 1.84 Mb region for macrosomia. Additional studies are needed to further characterize the candidate genes within these regions. © 2011 Wiley Periodicals, Inc.
Mathematical Analysis of Mandibular Morphogenesis by Micro‐CT‐Based Mouse and Alizarin Red S‐Stained‐Based Human Studies During Development
Authors: Rafiq Ashiq Mahmood , Udagawa Jun , Lundh Torbjörn , Jahan Esrat , Matsumoto Akihiro , Sekine Joji , Otani Hiroki 
Published: December 2011

AbstractPrenatal development of the mandible is an important factor in its postnatal function. To examine quantitatively normal and abnormal developmental changes of the mandible, we here evaluated morphological changes in mineralizing mandibles by thin‐plate spline (TPS) including bending energy (BE) and Procrustes distance (PD), and by Procrustes analyses including warp analysis, regression analysis, and discriminant function analysis. BE and PD were calculated from lateral views of the mandibles of mice or of human fetuses using scanned micro‐computed tomography (CT) images or alizarin red S‐stained specimens, respectively. BE and PD were compared (1) between different developmental stages, and further, to detect abnormalities in the data sets and to evaluate the deviation from normal development in mouse fetuses, (2) at embryonic day (E) 18.5 between the normal and deformed mandibles, the latter being caused by suturing the jaw at E15.5, (3) at E15.5 and E18.5 between normal and knockout mutant mice of receptor tyrosine kinase‐like orphan receptor (Ror) 2. In mice, BE and PD were large during the prenatal period and small after postnatal day 3, suggesting that the mandibular shape changes rapidly during the prenatal and early postnatal periods. In humans, BE of the mandibles peaked at 16–19 weeks of gestation, suggesting the time‐dependent change in the mandibular shape. TPS and Procrustes analyses statistically separated the abnormal mandibles of the sutured or Ror2 mutant mouse fetuses from the normal mandible. These results suggest that TPS and Procrustes analyses are useful for assessing the morphogenesis and deformity of the mandible. Anat Rec, 2012. © 2011 Wiley Periodicals, Inc.
Profiling conserved microRNA expression in recombinant CHO cell lines using illumina sequencing
Authors: Hammond Stephanie , Swanberg Jeffrey C. , Polson Shawn W. , Lee Kelvin H. 
Published: December 2011

AbstractMicroRNAs (miRNAs) are small, non‐coding RNAs that regulate multiple aspects of cell physiology. The differential expression of conserved miRNAs in two Chinese hamster ovary (CHO) cell lines producing recombinant proteins was examined relative to the CHO‐K1 cell line. A total of 190 conserved CHO miRNAs were identified through homology with known human and rodent miRNAs. More than 80% of these miRNAs showed differential expression in recombinant CHO cell lines. The small RNA sequencing data were analyzed in context of the CHO‐K1 genome to examine miRNA organization and develop sequence‐specific miRNA resources for CHO cells. The identification and characterization of CHO miRNAs will facilitate the use of miRNA tools in cell line engineering efforts to improve product yield and quality. Biotechnol. Bioeng. 2012; 109:1371–1375. © 2011 Wiley Periodicals, Inc.
Latest trends in LED lighting
Authors: Bessho Makoto , Shimizu Keiichi 
Published: December 2011

AbstractLED is the fourth and latest generation of light sources, following the first‐generation incandescent lamps, the second‐generation fluorescent lamps, and the third‐generation HID lamps. Their excellent characteristics, such as high efficiency, long life, compactness, light weight, zero mercury content, very slight IR and UV emissions, and the like, are advantages in comparison with conventional light sources. With the progress of LED lighting technologies, their application is spreading in sign and display devices, spot lighting, base lighting, and security lighting, and new applications that cannot be realized with conventional light sources are expected. This article reports the latest trends in LED lighting. © 2011 Wiley Periodicals, Inc. Electron Comm Jpn, 95(1): 1–7, 2012; Published online in Wiley Online Library (wileyonlinelibrary.com). DOI 10.1002/ecj.10394
The Nature of the Barrier to Phosphane Dissociation from Grubbs Olefin Metathesis Catalysts
Authors: Minenkov Yury , Occhipinti Giovanni , Heyndrickx Wouter , Jensen Vidar R. 
Published: December 2011

AbstractBy using cost‐efficient density functional theory accounting for dispersion in combination with an implicit solvent model, for the first time it has been possible to reproduce activation Gibbs free energies for phosphane dissociation from the Grubbs ruthenium olefin metathesis precatalysts in solution with good accuracy (mean unsigned error compared to experiment <2.5 kcal mol–1). The barrier is calculated to be in the range 17.8–25.7 kcal mol–1 for a set of nine catalysts, and is found to be located at intermediate Ru–P distances (ca. 4 Å). The agreement with the experimental activation parameters is gratifying and suggests that the calculations may give insight into these reactions and, in particular, offer resolution as to the individual components of the barriers. The forward (dissociation) barriers are much higher than the corresponding reaction free energies and the reverse reaction, phosphane binding, is associated with a significant barrier (13.2–15.6 kcal mol–1). The latter barrier mainly arises from loss of entropy and solute–solvent dispersion interactions for the two fragments prior to Ru–P bond formation. Moreover, the fact that the barrier to phosphane binding is so significant means that the reaction free energy of phosphane dissociation cannot be taken to be identical or similar to the forward barrier, as has occasionally been assumed in earlier studies.
Facile Synthesis of Porous Mn3O4 Nano­crystal–Graphene Nanocomposites for Electrochemical Supercapacitors
Authors: Wang Dewei , Li Yuqi , Wang Qihua , Wang Tingmei 
Published: December 2011

AbstractIn this work, we describe our efforts to produce Mn3O4–graphene nanocomposites based on a convenient andfeasible solution based synthetic route under mild conditions. According to transmission electron microscopy (TEM) and high angle annular dark field scanning transmission electron microscopy (HAADF‐STEM) results porous Mn3O4 nanocrystals (NCs), 20–40 nm in size, are uniformly deposited on both sides of the graphene nanosheet (GNS) matrix. Significantly, the as‐prepared Mn3O4–graphene nanocomposites exhibit remarkable pseudocapacitive activity including high specific capacitance (236.7 F g–1 at 1 A g–1), good rate capability (133 F g–1 at 8 A g–1), and excellent cyclability (the specific capacitance only decreases by 6.32 % of the initial capacitance after 1000 cycles). The excellent pseudocapacitive performance of the Mn3O4–graphene nanocomposites electrode is probably due to the positive synergistic effects between the Mn3O4 and GNS. Namely, the intimate combination of the conductive graphene network with uniformly dispersed porous Mn3O4 NCs not only greatly improves the electrochemical utilization of Mn3O4, but also increases the double‐layer capacitance of the graphene sheets. These characteristics make this nanocomposite a very promising electrode material for high performance supercapacitors.
7‐Arylnorbornanes: Model Compounds for the Study of CH···π and OH···π Interactions
Authors: Osío Barcina José , Fernández Israel , del Rosario Colorado Heras María 
Published: December 2011

AbstractPreorganised 7‐arylnorbornanes were selected as suitable model compounds for the study of CH···π and OH···π interactions. The most stable conformation of these derivatives favours such interactions by avoiding secondary hydrogen bonds between the oxygen atoms and the ortho‐H of the aryl rings in the planar conformation as well as by increasing the gauche/trans ratio for steric reasons. The rotational barriers of the studied compounds are higher when electron‐donor substituents are placed at the para position of the aryl ring. The trend of the electronic effects exerted by the substituents is in agreement with the existence of CH···π and OH···π interactions, which are favoured in electron‐rich aromatic systems. However, interestingly, DFT calculations show that the rotational barriers in these species are mainly governed by the occurrence of π(Cipso=C)→σ*(C–O) donations instead of the expected CH···π and OH···π hydrogen bonds. Both NMR and IR data support this hypothesis. Therefore, the assertion that the predominance of the gauche conformation is a proof of the presence of weak hydrogen bonds in benzyl alcohols and benzyl methyl ethers should be made with caution.
Work and back pain: A prospective study of psychological, social and mechanical predictors of back pain severity
Authors: Christensen J.O. , Knardahl S. 
Published: December 2011

AbstractStudies relating occupational psychological and social factors to back pain have traditionally investigated a small number of exposure factors. The current study explored longitudinally a comprehensive set of specific psychological/social and mechanical work factors as predictors of back pain severity (defined as the product of back pain intensity and duration). Employees from 28 organizations in Norway, representing a wide variety of occupations, were surveyed with a follow‐up period of 2 years. Several designs were tested: (1) cross‐sectional analyses at baseline and follow‐up; (2) prospective analyses with baseline exposure; (3) prospective analyses with average exposure over time [(T1+T2)/2]; and (4) prospective analyses with measures of change in exposure from T1 to T2. A total of 2808 employees responded at both time points. Fourteen psychological/social and two mechanical exposures were measured. Odds ratios (ORs) were computed by ordinal logistic regressions. Several psychological/social factors predicted back pain severity. After adjustment for age, sex, skill level, back pain severity at T1 and other exposure factors estimated to be potential confounders, the most consistent predictors of back pain were the protective factors decision control [lowest OR 0.68; 99% confidence interval (CI): 0.49–0.95], empowering leadership (lowest OR 0.59; 99% CI: 0.38–0.91) and fair leadership (lowest OR 0.54; 99% CI: 0.34–0.87). Some of the most important predictors included in this study were factors that have previously received little attention in back pain research. This emphasizes the importance of extending the list of factors possibly contributing to back pain.
The impact of spinal cord stimulation on physical function and sleep quality in individuals with failed back surgery syndrome: A systematic review
Authors: Kelly G.A. , Blake C. , Power C.K. , O'Keeffe D. , Fullen B.M. 
Published: December 2011

AbstractThe aim of this review was to determine the impact of spinal cord stimulation (SCS) on physical function and sleep quality in individuals with failed back surgery syndrome (FBSS). This review comprised three phases: an electronic database search (PubMed, Cinahl Plus, EMBASE, PsychInfo, Pedro, Cochrane Library) identified potential papers; these were screened for inclusion criteria, with extraction of data from accepted papers and rating of internal validity by two independent reviewers using the Effective Public Health Practice Project quality assessment tool, a tool designed to assess non‐RCTs (randomized controlled trials) as well as RCTs. Strength of the evidence was rated using the Agency for Health Care Policy and Research guidelines. The search generated 13 quantitative papers that fulfilled the inclusion criteria; all 13 studies investigated the impact of SCS on physical function, and nine studies investigated the impact of SCS on sleep quality. Consistent evidence (level C) found that SCS positively affected physical function, with improvements in participation in activities of daily living, leisure, social and work‐related activities. Similarly, consistent evidence (level C) found improvements in sleep quality following SCS. Improvements in sleep quantity, a reduction in awakenings and a decrease in sleep medication use were also noted (level D). The impact of SCS on cognitive function, i.e., memory and concentration, was also assessed using the same search strategy, no papers fulfilled the inclusion criteria for this study. Spinal cord stimulation effectively addressed many physical function and sleep problems associated with FBSS; however, there is a need for further high‐quality objective investigations to support this.
Influence of organic acids present in the oral biofilm on the microtensile bond strength of adhesive systems to human dentin
Authors: Silva Eduardo M. , Almeida Giselle S. , Poskus Laiza T. , Guimarães José Guilherme A. 
Published: December 2011

AbstractThis study evaluated the influence of organic acids present in the oral biofilm on the microtensile bond strength (μTBS) of adhesive systems to human dentin. Sixty occlusal dentin surfaces were wet ground with 600 grit SiC abrasive paper and divided into four groups according to the adhesive systems: Scotchbond Multipurpose (SMP), Adper Single Bond 2, Adper Scotchbond SE (ASE), and Clearfill SE Bond (CSE). After the adhesive systems were applied, a block of resin composite was built up on the dentin surfaces. After 24 h storage in distilled water at 37°C, the teeth were perpendicularly cut to obtain beams (1 mm2). For each adhesive system, the beams were divided into three groups according to storage media: artificial saliva (AS); propionic acid (PA), and lactic acid (LA). After 7 days storage at 37°C, the beams were submitted to μTBS testing. The μTBS ranged from 36.0 ± 1.6 (ASE‐PA) to 52.5 ± 1.2 (CSE‐AS). For all adhesive systems, the μTBS values after storage in PA were lower than those in AS. Except for the SMP, the values of μTBS after storage in LA were lower than those in AS. The adhesive ASE presented the lowest values of μTBs in the three media. The acids present in the oral biofilm may affect the bond strength of adhesive systems to human dentin. © 2011 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2012.
Temperature‐Responsive Aqueous Micelles From Terpyridine End‐Capped Poly(N‐Isopropylacrylamide)‐Block‐Polystyrene Diblock Copolymers
Authors: Piogé Sandie , Fustin Charles‐André , Gohy Jean‐François 
Published: December 2011

AbstractAn attractive concept for designing “smart materials” is the combination of supramolecular interactions with thermoresponsive polymers. Here, this concept is illustrated by preparing aqueous micelles from poly(N‐isopropylacrylamide)‐block‐polystyrene copolymers functionalized at the extremity of their poly(N‐isopropylacrylamide) coronal chains by terpyridine ligands. The effect of temperature and of the addition of Zn(II) ions on the self‐assembling properties is then studied.
Retrospective reconstruction of high temporal resolution cine images from real‐time MRI using iterative motion correction
Authors: Hansen Michael S. , Sørensen Thomas S. , Arai Andrew E. , Kellman Peter 
Published: December 2011

AbstractCardiac function has traditionally been evaluated using breath‐hold cine acquisitions. However, there is a great need for free breathing techniques in patients who have difficulty in holding their breath. Real‐time cardiac MRI is a valuable alternative to the traditional breath‐hold imaging approach, but the real‐time images are often inferior in spatial and temporal resolution. This article presents a general method for reconstruction of high spatial and temporal resolution cine images from a real‐time acquisition acquired over multiple cardiac cycles. The method combines parallel imaging and motion correction based on nonrigid registration and can be applied to arbitrary k‐space trajectories. The method is demonstrated with real‐time Cartesian imaging and Golden Angle radial acquisitions, and the motion‐corrected acquisitions are compared with raw real‐time images and breath‐hold cine acquisitions in 10 (N = 10) subjects. Acceptable image quality was obtained in all motion‐corrected reconstructions, and the resulting mean image quality score was (a) Cartesian real‐time: 2.48, (b) Golden Angle real‐time: 1.90 (1.00–2.50), (c) Cartesian motion correction: 3.92, (d) Radial motion correction: 4.58, and (e) Breath‐hold cine: 5.00. The proposed method provides a flexible way to obtain high‐quality, high‐resolution cine images in patients with difficulty holding their breath. Magn Reson Med, 2012. © 2011 Wiley Periodicals, Inc.
Synthesis of a new hyperbranched‐linear‐hyperbranched triblock copolymer and its use as a chemical modifier for the cationic photo and thermal curing of epoxy resins
Authors: Foix D. , Ramis X. , Sangermano M. , Serra A. 
Published: December 2011

AbstractA new hyperbranched‐linear‐hyperbranched polymer was prepared in a one pot process by reaction of 4,4‐bis(4‐hydroxyphenyl)valeric acid and poly(ethylene glycol) (HPH). After characterization by 1H and 13C NMR, SEC, DSC, and TGA, this polymer was used, in proportions of 5, 10, and 15 phr, as a chemical modifier in the UV and thermal cationic curing of 3,4‐epoxycyclohexylmethyl‐3′,4′‐epoxycyclohexyl carboxylate epoxy resin. The curing process was studied by calorimetry, demonstrating the accelerating effect of the hydroxyl groups present in HPH's structure. The morphology of the resulting thermosets depended on the curing system used, as demonstrated by FE‐SEM microscopy, but in both cases phase separation occurred. Thermosets obtained by thermal curing presented lower thermal stability than UV‐cured materials. © 2011 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem, 2012
Tunable capacitive inter‐dot coupling in a bilayer graphene double quantum dot
Authors: Fringes Stefan , Volk Christian , Terrés Bernat , Dauber Jan , Engels Stephan , Trellenkamp Stefan , Stampfer Christoph 
Published: December 2011

AbstractWe report on a double quantum dot which is formed in a width‐modulated etched bilayer graphene nanoribbon. A number of lateral graphene gates enable us to tune the quantum dot energy levels and the tunneling barriers of the device over a wide energy range. Charge stability diagrams and in particular individual triple point pairs allow to study the tunable capacitive inter‐dot coupling energy as well as the spectrum of the electronic excited states on a number of individual triple points. We extract a mutual capacitive inter‐dot coupling in the range of 2–6 meV and an inter‐dot tunnel coupling on the order of 1.5 µeV. (© 2012 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Assimilation of water‐vapour airborne lidar observations: impact study on the COPS precipitation forecasts
Authors: Bielli S. , Grzeschik M. , Richard E. , Flamant C. , Champollion C. , Kiemle C. , Dorninger M. , Brousseau P. 
Published: December 2011

AbstractThe Convective and Orographically‐driven Precipitation Study (COPS) carried out in summer 2007 over northeastern France and southwestern Germany provided a fairly comprehensive description of the low‐troposphere water‐vapour field, thanks in particular to the deployment of two airborne differential absorption lidar systems. These lidar observations were assimilated using the 3D‐Var assimilation system of the Application of Research to Operations at MEsoscale (AROME) numerical weather prediction mesoscale model. The assimilation was carried out for the period 4 July–3 August by running a three‐hour forward intermittent assimilation cycle. First, the impact of the lidar observations was assessed by comparing the analyses with a set of more than 200 independent soundings. The lidar observations were found to have a positive impact on the analyses by reducing the dry bias in the first 500 m above ground level and by diminishing the root‐mean‐square error by roughly 15% in the first km. Then the impact of the lidar observations was assessed by comparing the precipitation forecasts (obtained with and without the lidar observations for the period 15 July–2 August) with the gridded precipitation observations provided by the Vienna Enhanced Resolution Analysis. In general, the impact was found to be positive but not significant for the 24 h precipitation and positive and significant for the 6 h precipitation, with an improvement lasting up to 24 h. Some selected case studies show that the improvement was obtained through a better depiction of convection initiation or through a more accurate positioning of the precipitation systems. Copyright © 2011 Royal Meteorological Society