bluuebunny/crossref_metadata_2025_split huggingface dataset:
P03-364 Comparison of Intramuscular Ziprasidone and Haloperidol for Acute Psychotic Agitation in an Emergency Room
Authors: Martínez-Formoso S. , Ramos-Ríos R. , Tajes-Alonso M. , Arrojo-Romero M. 
Published: June 2010

ObjectivesTo compare the efficacy and safety of the intramuscular formulations of ziprasidone and haloperidol in treating agitation in schizophrenic patients attended in an emergency room.MethodConsecutive patients were alternatively assigned to receive 20 mg of IM ziprasidone or 10 mg of IM haloperidol. Efficacy measures were improvement in Behavioral Activity Rating Scale (BARS), in the sum of five items of the Positive and Negative Syndrome Scale that focused on agitation (PANSS-A) and scores on the Clinical Global Impression improvement scale (CGI-I), obtained 45 minutes and 2 hours after the IM medication. Tolerability assessments included changes in ECG, monitoring of vital signs and register of adverse events.ResultsFinally 18 patients (13 men, mean age 40.8 ±10.2) were included in the analysis of data. At arrival in the emergency room, there were no differences between ziprasidone (Z) and haloperidol (H) groups in age, mean QTc length, mean BARS and mean PANSS-A scores. Analyzing the global sample there was an improvement in agitation scores. No significant differences were found between the groups in change of BARS and PANSS-A scores, in CGI-I scores or in the variation of the length of QTc interval at two hours. No serious adverse events were reported.ConclusionsIn spite of the small sample size, both treatments ziprasidone IM and haloperidol IM seems to be similarly effective for the management of psychotic agitation in the emergency room. Both were well tolerated. Lengthening of QTc interval due to ziprasidone IM had not been found in our sample.
P03-365 - Venlafaxine and CYP2D6 in Clinical Practice: Work in Progress
Authors: Zeppegno P. , Rolla R. , Dalò V. , Ressico F. , Parafioriti A. , Prosperini P. , Vidali M. , Bellomo G. , Torre E. 
Published: June 2010

ObjectiveVenlafaxine (V) is a SNRI metabolized primarily by the highly polymorphic cytochrome P4502D6 enzyme (CYP2D6) in O-desmethylvenlafaxine (ODV), the main active metabolite. Four CYP2D6 metabolizer phenotypes have been identified: poor (PM), intermediate (IM), extensive (EM) and ultrarapid (UM). Approximately 5-10% Caucasians are PMs; in these individuals metabolism of substrate is decreased and adverse clinical effects may be expected. The effectiveness of pharmacogenetic tests is controversial because the association between plasma levels of V/ODV and side effects is not attested.We discuss the association between CYP2D6-genotype and Venlafaxine clinical effects.MethodsWe will recruit Caucasian patients aged 18 to 65, eligible for Venlafaxine treatment, satisfying DSM-IV criteria for major depressive episode, dysthymia or depressive adjustment disorder. Exclusion criteria will be: pregnancy, acute suicidality, alcohol/substance abuse, concomitant/prior antidepressive treatment in the previous 3 months. We will assess patients’ age, gender, DSM-IV diagnosis, Venlafaxine dose, concomitant pharmacological treatment, BMI, BP, tobacco use, liver and kidney functionality. Clinical response and side effects will be monitored using CGI, HAM-D and SIDE at T0 (onset), T1 (1 week later) and T2 (6 weeks later).The patients will be analyzed for the presence of 16 CYP2D6-genotype variants by INFINITITTM CYP2D6 assay which utilizes AutoGenomics proprietary film-based microarray technology.ResultsWe expect to find out a correlation between CYP2D6-genotype, Venlafaxine dose and clinical response to treatment.ConclusionsWe will investigate whether a pharmacogenetic test prior to treatment can be useful in clinical practice to detect a proper Venlafaxine dosage or to switch to a different drug.
P03-367 - Sertindole in the Treatment of Tardive Dyskinesia in a Patient with Genetically Abnormal Dopamine D3 Receptors
Authors: Rizos E. , Douzenis A. , Michopoulos I. , Siafakas N. , Katsantoni E. , Gournellis R. , Lykouras L. 
Published: June 2010

ObjectiveTardive dyskinesia (TD) is a difficult-to-treat condition. The presence of genetically abnormal D2 and D3 dopamine receptors is associated with increased like hood of TD in patients with schizophrenia. We present a case of a patient with TD and genetically abnormal dopamine D3 receptors with chronic schizophrenia, treated successfully by sertindole.MethodsA 47-year old male with history of chronic chizophrenia was assessed clinically by means of SCID IV, PANSS and AIMS, and was genotyped for DRD3ser-gly and 5-HT2C receptor gene polymorphisms.ResultsThe patient suffered from an exacerbation of positive and negative psychotic symptoms and TD. He was also found to be DRD3ser-gly heterozygous. He had been suffering from TD for two years, developed by chronic administration of haloperidole and resperidone. A trial with quetiapine failed to ameliorate his TD and psychotic symptoms, whereas a successive trial with clozapine induced life-treating hematological side effects. After the administration of sertindole (16mh/day) his psychotic and TD symptoms remitted (PANSS:29, AIMS : 0). One year later his level of improvement was wholly preserved.ConclusionSertindole might be beneficial for the treatment of TD in patients who have genetically abnormal D3 receptors.
P03-370 - Effect of Transcranial Magnetic Stimulation in Pharmacoresistant Depression
Authors: Sakkas P. , Tzavellas E. , Zaloni R. , Paparrigopoulos T. , Papadimitriou G. 
Published: June 2010

BackgroundTranscranial magnetic stimulation (TMS) is a novel treatment for patients with depressive disorder. TMS is a noninvasive method to excite neurons in the brain: weak electric currents are induced in the tissue by rapidly changing magnetic fields. We report two cases suffering from pharmacoresistant depression and the efficacy of TMS in their treatment.CasesThe first case was a 45-year-old male Caucasian patient suffering from unipolar depression and the second case was a 53-year-old female Caucasian patient suffering from bipolar depression.The patients were under treatment with SSRI, SNRI, NASSA (one medicine or combination of them) without any or minor improvement.So TMS sessions were performed daily in both patients for a period of one month.DiscussionA marked reduction of depressive symptoms was demonstrated in both patients. Thus, TMS sessions may help the pharmacoresistant depression by minimizing physical and subjective discomfort. Furthermore TMS appears to be safer and better tolerated than many others medicines or electroconvulsive therapy. Further studies are needed in order to investigate the effect of TMS in resistant depression
P03-375 - Audit on use of Hypnotics for Insomnia in Comparison with National Institute of Clincal Excellence Guidelines
Authors: Singh G. , Bhardwaj R. 
Published: June 2010

ObjectiveTo compare prescribing practices of hypnotics against NICE guidelines (National Institute of Clinical Excellence) and to develop recommendations with action plan. The NICE recommends:•Due consideration should be given to non-pharmacological measures prior to hypnotic prescription.•Hypnotics should be prescribed for short periods of time only (maximum 4 weeks)•The drug with the lowest purchase cost should be prescribed.•Switching from one hypnotic to another should only occur if a patient experiences adverse effects.MethodologyThe audit tool was developed. The data was compiled using medical records of the patients who were seen during a specified three month time period in an out-patient setting. A total sample size of 308 was generated out of which 41(12.5%) were being prescribed hypnotics. The medical records of these 41 patients were scrutinised to gather evidence whether NICE guidelines were adhered to. The data was analysed using the tool recommended by NICE.ResultsThe significant results are:•Only 25% of the patients were advised Non-pharmacological measures.•Duration of prescription ranged from one week to more than 10 years, with 33% approximately being prescribed for less than one year, and 10% being prescribed for more than 10 years.•There is no evidence that consideration was given to cost while prescribing.•Only in one patient hypnotic was switched. However, there was no evidence of adverse reaction which could be directly related to the hypnotic prescribed.ConclusionsThe overall compliance with guidelines was found to be 42%.
P03-378 - Dramatic Response of Resistant Obsessive Compulsive Disorder to Repeated Transcranial Magnetic Stimulation, a Case Report
Authors: Talaei A. 
Published: June 2010

IntroductionThe response rate of obsessive compulsive disorder is 21.6% to 61.3%; which shows the relative resistance to current treatments and a need for novel methods. Here, we have reported a case of resistant obsessive compulsive disorder (OCD) with fast and dramatic response to a relatively new method named repeated transcranial magnetic stimulation (rTMS). In rTMS a pulse magnetic field is emitted from a coil over the surface of the scalp which induces a localized electrical current in the cortex below. Cortical activity can then be either inhibited or stimulated.Case reportThe patient is a 40 years old female admitted for severe OCD in Mashhad Ibn-e-Sina Psychiatric Hospital. The patient was treated with 10 sessions of rTMS on right supplementary motor area (SMA) with 110% intensity, 1 Hz frequency and duration of 30 minutes per day (a total of 1200 pulses per day). Improvement of patient was evaluated serially with Yale Brown scale. By the end of the 2nd day she reported a major improvement of her symptoms. Her improvement was so dramatic in obsessive and compulsive behaviors and her avoidance recovered completely. She also reported significant improvement in her ability to control her obsessive thoughts and impulses and her anxiety symptoms.ConclusionConsidering that rTMS is a low risk method and has almost no interaction with the common medications and the faster response with this method, it seems that it can be used as supplementary treatment in resistant cases and even in the initial stages of OCD.
P02-295 - Mental and Psychosomatic Disorders at Children and the Teenagers who Have Suffered Owing to Chernobyl Accident
Authors: Berezovsky V. , Panchenko L. , Garazha M. , Basarab I. 
Published: June 2010

Objective78 children and the teenagers. The first group - 6-11 years - 35 people (44,9%), the second group - 12-15 years - 43 people (55,1%).Methodskliniko-psychiatric, psychodiagnostic: «family Drawing», «the Nonexistent animal», a questionnaire «diagnostics presence of fears» by the Rostov medical university, ЕРI, a children's questionnaire of neurosises, uneasiness school.ResultsThe raised weariness and uneasiness are revealed at the 51 (65,4±5,4%) schoolchildren. Intensity and the emotional stress connected with school, were marked almost at the every second child with problems in study and at the every third in time pupil. These persons more often had psychosomatic diseases, school phobias, attention frustration, hyperactivity. 42 people (53,8±5,6%) have been established the diagnosis of vegeto-vascular dystonia. It is children and the teenagers more often suffering allergic diseases, a squint, an enuresis, stutter. 12 (15,4±4,1%) children and teenagers feel fear before to parents. The greatest quantity is necessary on “medical” fears - 22 people (28,2±5,1%) among the fixed fears. Then the fears were distributed connected with causing of a physical damage - 16 people (20,5±4,6%) and socially mediated fears - 11 people (14,1±3,9%). Aggression has been fixed at 27 people (34,6±5,4%) surveyed.ConclusionsPsychological characteristics of children and the teenagers who have suffered owing to Chernobyl accident specify in high level neurotizen and family desadaptation, uneasiness, depressive, high degree neurotizen. The psychotherapy is the basic means of treatment and preventive maintenance in system of complex social-psychological rehabilitation: dezactual neurotic semiology; symptomatic psychocorrection; socially-psychological correction; individual and family correctional work.
P02-296 - Correlation Between Personality Structure and Symptoms of Anxiety or Depression and Quality of Achieved Metabolic Control of Diabetes
Authors: Brankovic A. , Pudar G. 
Published: June 2010

Many studies bring out the influence of personality structure on the way patients with chronic disease/diabetes accept their illness. The aim of this study was to determine connection between patients personality characteristics, their depressive/anxious reaction and quality of glycoregulation.We examined 90 patients with both types of diabetes, age 20 to 75 years. All patients were followed during six months. At the beginning we determined their personality types (Persona test) and personality traits (Eysenck Personality Questionnaire). During the study plasma glucose concentrations, HbA1c, body weight and height and BMI were followed. Also we followed the presence of depression and anxiety by using Hamilton anxiety and depression scales.Almost all patients (96,67%) had expressed trait of neuroticism (p< 0,01). Most patients (51%) had facilitator personality type (p< 0,01). The presence of depression and anxiety didn’t depend significantly on patient's personality type. The duration of diabetes had high influence on manifestation of depression and anxiety, especially in patients with diabetes type 1 (p< 0,01). During this study the number of highly anxious patients decreased in group type 2 (p< 0,05) but remained the same in group type 1 diabetes (p< 0,05). The positive correlation between expression of depression and anxiety was found (p< 0,01). At the end of this study glycoregulation was improved in all patients (p< 0,01), especially in group of facilitators and promoters.The achieved improvement in therapy acceptance and diabetes control points out the importance of patient psychological evaluation and appropriately adjusted support, motivation and education in their treatment.
P02-297 - Neurocognitive Functioning in Untreated Patients with Bulimia Nervosa: Neuroendocrine, Personality and Clinical Correlates
Authors: Bucci P. , Galderisi S. , Mucci A. , Bellodi L. , Cassano G.B. , Santonastaso P. , Erzegovesi S. , Favaro A. , Mauri M. , Tenconi E. , Monteleone P. , Maj M. 
Published: June 2010

ObjectivesCognitive impairment in patients with eating disorders was reported by the majority of studies addressing this issue. However, heterogeneous patterns of cognitive dysfunctions were observed and, in a minority of studies, no impairment was found. The present study was aimed to define the pattern of neurocognitive impairment in a large sample of bulimia nervosa (BN) patients and to demonstrate that neuroendocrine, personality and clinical characteristics influence neurocognitive performance in BN.MethodsAttention, executive control, conditional and incidental learning were evaluated in 83 untreated female patients with BN and 77 healthy controls. Cortisol and 17β-estradiol plasma levels were assessed. Cloninger's Temperament and Character Inventory-Revised (TCI-R), the Eating Disorder Inventory-2 and the Montgomery-Asberg Depression Rating Scale were administered.ResultsNo impairment of cognitive performance was found in subjects with BN vs. healthy controls. The higher the cortisol level and “Self-directedness” scores the better the performance on conditional learning, while 17β-estradiol levels showed an opposite pattern of association; “Reward dependence” scores were associated to a worse performance on incidental learning; depressive symptomatology negatively influenced the performance on the WCST.ConclusionsNo cognitive impairment was found in untreated patients with BN in the explored cognitive domains. An influence of neuroendocrine, personality and clinical variables on neurocognitive functioning was found, which might explain discrepancies in literature findings.
P02-303 - Anxio-Depressifs Troubles and Diabetes Type 2
Authors: Halwani N. , Mnif L. , Masmoudi J. , Baati I. , Feki A. , Haj Kacem H. , Ayadi N. , Jaoua A. 
Published: June 2010

The objective of our study is to estimate the prevalence of depression, anxiety and alexithymia, of patients presenting a diabetes type 2 and their echo on the disease.MethodOur study, descriptive and forward-looking, was led with diabetics type 2, consulting in the service of endocrinology of HEDI CHAKER Hospital of Sfax.The collection of the information was realized with the help of:-A data sheet containing socio-demographic data and clinical data concerning the diabetes.-Hospital-Anxiety and Depression Scale (HADS).-Toronto Alexithymia Scale of 20 items.ResultsOur sample consisted of 96 diabetics: 67 women and 29 men.The average age was of 56.23 years (ET=10, 85)The prevalence of depression was 32.3%, that of anxiety was 56. 3%.The alexithymia was estimated at 46.9%.The depression was correlated to the presence of cardiac co-morbidity (p=0,012).High prevalence of depression was found in diabetic's suffering from neurological (0.002) and renal (p=0.007) complications.The depression was the source of a less regular follow-up.The association depression-alexithymia was correlated at a less good balance of the diabetes (p=0.038).The anxiety does not seem to interfere with the clinical characteristics of the type 2 diabetes.Discussion and conclusionDiabetics suffering from depression have more co-morbidity and complications. This risk was increased by the association of alexithymia. So, a screening of the psychiatric symptoms is necessary to improve the quality of life and the evolution of the disease.
P02-331 - Trauma, Attachment and Personality Development
Authors: Ammon M. 
Published: June 2010

The paper gives an overview about classic psychoanalytic formulations of psychic trauma and compares them with recent contributions from trauma therapy, attachment research, and neurobiology. It focuses especially on Günter Ammon's understanding of early relationship trauma and its consequences for personality development. After reviewing relevant trauma-therapeutic approaches in contemporary psychoanalysis, Ammon's therapeutic concept for patients with early traumatizations is outlined. Finally the realization of this concept in Dynamic Psychiatry, e. g. the therapeutic setting of the clinic Menterschwaige, is described.ObjectivesThe paper gives an overview about classic psychoanalytic formulations of psychic trauma and compares them with recent contributions from trauma therapy, attachment research, and neurobiology.MethodsBrain research and psychotherapeutic methodes.ResultsResults of the brain research show that early traumatization affects brain areas in emotional states which verbalization cannot reach.ConclusionsFor early traumatized patients a treatment concept of non-verbal methods as well as verbal are necessary,
P02-333 - Efficacy of Cognitive-Behavioral Therapy for the Treatment of Recurrent Depression in Adults
Authors: Carvalho M. , Estevens D. , Guete-Tur O. 
Published: June 2010

ObjectivesSeveral studies, carried out to assess the efficacy of psychological and pharmacological treatments for depression, have shown thar combined treatments are, in general, more efficacious than an unique approach. We will present the preliminary results of an on-going research, being carried out with the main purpose of analysing the efficacy of two psychological empirically supported treatments, Cogntiive-Behvioral therapy (CBT) and Interpersonal Therapy (IPT), combined with a pharmacological antidepressive (AD) intervention, for recurrent depression.MethodsA sample of 20 adult females has been randomly assigned to one of three conditions: a) CBT plus AD, b) IPT plus AD, and c) AD only.A multimodal assessment matrix was developed and is being used to evaluate depression features (including suicidal ideation, intention and attempts), and the main individual, social, and environmental factors commonly related to the onset and mantainance of the disorder, namely hopelessness and pessimism, cognitive processing, interpersonal relations, and life events.Repeated measurements are being collected at 0, 2, 4, and 6 months, and follow-up.ResultsWe expect that both combined approches will be more efficacious for the reduction of depressive symptoms, including suicidal behaviors, compared to the pharmacological approach. we also expect to understand the sensitivity to change of the assessed psychological processes underlying each form of psychotherapy.
P02-352 - Outpatient Group Psychotherapy: Impact on Number and Mean Duration of Re-Entries in Acute Inpatient Unit
Authors: Marin Diaz-Guardamino E. , Bravo Barba E. , Larrañaga Rementeria L. , Hervella Garces I. , Garcia Ormaza J. , Segarra Echevarria R. , Eguiluz Uruchurtu I. 
Published: June 2010

IntroductionOutpatient group psychotherapy began in our department in 2002 as a complement to the acute inpatient unit. Patients with heterogeneous diagnoses were included before or after a short-duration stay in the unit. Clinicians’ impression was that re-entries to the acute unit were less frequent and shorter after group therapy.ObjectivesThe objective is to determine the real impact of group psychotherapy on the number and mean duration of these re-entries.MethodsData was collected for 156 patients during period of two years. The number and mean duration of hospitalization in the psychiatric acute unit were registered for each patient during the year before and in the year after therapy to be analyzed and compared.ResultsBefore attending group psychotherapy 60.3% of the patients were hospitalized in the acute unit (39.1% once, 12.8% twice, 6.4% three times, 1.9% four times). 65.4% had no re-entries in the following year; 71% of those who did had one re-entry. The mean number of entries per year in the acute unit before therapy was 0.92, while the mean after therapy was 0.52. The mean stay was 7.86 days before therapy, and 4.62 days after. The mean differences between before and after entries were significant in statistical analyses.ConclusionsGroup psychotherapy seems to have effects on number and duration of re-entries to the acute unit for most patients in the different diagnostic categories. These findings have important implications, as this form of therapy is cost-effective and available for a wide range of psychiatric patients.
P02-356 - Social Implications of Group Psychotherapy on Chronic Psychoses
Authors: Mitric B. , Macic A. , Radoman N. 
Published: June 2010

IntroductionCenter for mental health is established in May of year 2005. Center for mental health promotes the mental health care in the community.ObjectiveTo evaluate the effect of group psychotherapy on chronic psychoses, ambulatory treated in Mental Health Center in Kotor, Montenegro.AimsThe influence of the effect of group psychotherapy on chronic psychoses in the development of optimal socialization.MethodThe group consists of patients who were coming for regular check-ups in our health center during previous 3 years. The group is semi-opened and it is heterogeneous in respect to gender and age. The effect is estimated by observing the behavior of group dynamics. There were 8 regular members in this group and additional ones who participated occasionally, on suggestion of their psychiatrist.ResultsDuring the initial group meetings it was noticed that the patients are not familiar with each other, even though they were previously treated in our local psychiatric hospital and are inhabitants of a same, small town. They didn’t communicate with each other and didn’t even know each others names. They were distrustful toward new group members and couldn’t think of the questions to ask when the new members were presented to them. After six months, group members formed friendship relationships.DiscussionEvaluation of the effect of group psychotherapy on chronic psychoses treated ambulatory is facilitating the development of optimal socialization as well as optimal interpersonal relationships within group, in respect to the nature and progression of mental disorder.