bluuebunny/crossref_metadata_2025_split huggingface dataset:
Phenotyping airway disease with optical coherence tomography
Authors: COXSON Harvey O. , EASTWOOD Peter R. , WILLIAMSON Jonathan P. , SIN Don D. 
Published: November 2010

ABSTRACTAirway diseases are a major concern around the world. However, the pace of new drug and biomarker discovery has lagged behind those of other common disorders such as cardiovascular diseases and diabetes. One major barrier in airway research has been the inability to accurately visualize large or small airway remodelling or dysplastic/neoplastic (either pre or early cancerous) changes using non‐ or minimally invasive instruments. The advent of optical coherence tomography (OCT) has the potential to revolutionize airway research and management by allowing investigators and clinicians to visualize the airway with resolution approaching histology and without exposing patients to harmful effects of ionizing radiation. Thus, with the aid of OCT, we may be able to accurately determine and quantify the extent of airway remodelling in asthma and chronic obstructive pulmonary disease, detect early pre‐cancerous lesions in smokers for chemoprevention, study the upper airway anatomy of patients with obstructive sleep apnea in real time while they are asleep and facilitate optimal selection of stents for those with tracheal obstruction. In this paper, we review the current state of knowledge of OCT and its possible application in airway diseases.
Capsule-Pipelining—An Improved Theoretical Analysis
Authors: Garg V. K. 
Published: November 2010

Abstracts
This paper provides an improvement over the earlier theoretical analysis for a rigid, frictionless, cylindrical capsule moving parallel to the horizontal pipe wall (Garg and Round [1]) by taking into account the effects of friction between the capsule and pipe surfaces and of nonuniform clearance over the capsule length. It is found that these effects markedly affect the energy requirements suggesting, thereby, an optimum operation of the capsule-pipeline system. The theoretical results are also compared with the available experimental data.
Deploying Mouse Models of Pancreatic Cancer for Chemoprevention Studies
Authors: Grippo Paul J. , Tuveson David A. 
Published: November 2010

Abstract
With the advent of mouse models that recapitulate the cellular and molecular pathology of pancreatic neoplasia and cancer, it is now feasible to recruit and deploy these models for the evaluation of various chemopreventive and/or anticancer regimens. The highly lethal nature of pancreatic ductal adenocarcinoma (PDAC) makes multiple areas of research a priority, including assessment of compounds that prevent or suppress the development of early lesions that can transform into PDAC. Currently, there are over a dozen models available, which range from homogeneous preneoplastic lesions with remarkable similarity to human pancreatic intraepithelial neoplasms to models with a more heterogeneous population of lesions including cystic papillary and mucinous lesions. The molecular features of these models may also vary in a manner comparable with the differences observed in lesion morphology, and so, navigating the route of model selection is not trivial. Yet, arming the community of cancer investigators with a repertoire of models and the guidance to select relevant models that fit their research themes promises to produce findings that will have clinical relevance. Cancer Prev Res; 3(11); 1382–7. ©2010 AACR.
Pseudaphelenchus vindai n. sp. (Tylenchomorpha: Aphelenchoididae) associated with termites (Termitidae) in Barro Colorado Island, Panama
Authors: Kanzaki Natsumi , Giblin-Davis Robin M. , Herre E. Allen , Scheffrahn Rudolf H. , Center Barbara J. 
Published: November 2010

Abstract
In 2008, a field survey of termite-associated nematodes was conducted on
Barro Colorado Island, Smithsonian Tropical Research Institute (BCI, STRI),
Panama. During that survey, an undescribed Pseudaphelenchus species was
isolated from three species of subterranean termites, Amitermes beaumonti,
Microcerotermes exiguous and Obtusitermes panamae. The nematode is described
and figured herein as P. vindai n. sp. The new species is morphologically
similar to its only congener, P. yukiae, i. e., these two species share a
thin stylet with small and clear basal knobs, a true bursa supported by
three bursal limb-like genital papillae and a nerve ring surrounding the
anterior clear region of the pharyngeal gland lobe and intestine. The
molecular phylogenetic analysis based upon near full length (ca 1.7 kb) SSU
ribosomal DNA sequence suggested that the new species forms a well supported
clade with P. yukiae, at the basal position of the family Aphelenchoididae.
The new species is distinguished from P. yukiae by possessing a clear
condylus and rostrum of the capitulum and arcuate calomus/lamina complex of
the spicules vs no condylus and rostrum and a relatively straight
calomus/lamina complex, long and tapering female tail without small mucro vs
blunt with small mucro present and possession of lateral field with three
incisures vs four incisures.
The Effect of Sevoflurane Inhalation on Gabaergic Neurons Activation: Observation on the GAD67‐GFP Knock‐In Mouse
Authors: Han Li‐Chun , Zhang Hui , Wang Wei , Wei Yan‐Yan , Sun Xing‐Xing , Yanagawa Youchio , Li Yun‐Qing , Xu Li‐Xian , Wu Sheng‐Xi 
Published: November 2010

AbstractThe mechanisms underlying volatile anesthesia agents are not well elucidated. Emerging researches have focused on the participation of γ‐aminobutyric acid (GABA) neurons but there still lacks morphological evidence. To elucidate the possible activation of GABAergic neurons by sevoflurane inhalation in morphology, Fos (as neuronal activity marker) and GABA neurons double labeling were observed on the brain of glutamic acid decarboxylase (GAD) 67‐GFP knock‐in mice after sevoflurane inhalation. Twenty GAD67‐GFP knock‐in mice were divided into three groups: S1 group: incomplete anesthesia state induced by sevoflurane; S2 group: complete anesthesia state induced by sevoflurane; control(C) group. Sevoflurane induced a significant increase of Fos expression in the dorsomedial hypothalamic nucleus (DM), periaqueductal grey (PAG), hippocampus (CA1, DG), paraventricular thalamic nucleus (PV), lateral septal nucleus (LS), and cingulate cortex (Cg1 and Cg2) in S1 group compared to C group, and increase of Fos expression in S2 group compared to S1 group. In S2 group, Fos was only expressed in the medial amygdaloid nucleus (MeA), Edinger–Westphal (E–W) nucleus, arcuate hypothalamic nucleus (Arc) and the ventral part of paraventricular hypothalamic nucleus (PaV). Double immunofluroscent staining indicated that in LS, almost all Fos werepresent in GABAergic neurons. In CA1, DG, DM, cg1, cg2, and PAG, Fos was expressed as well, but only few were present in GABAergic neurons. Fos expression was very high in thalamus, but no coexistence were found as noGABAergic neuron was detected in this area. Our results provided morphological evidence that GABAergic transmission in specific brain areas may participate in the sevoflurane‐induced anesthesia. Anat Rec, 2010. © 2010 Wiley‐Liss, Inc.
Querkrafttragfähigkeit von Stahlbetonträgern
Authors: Sigrist Viktor , Hackbarth Britta 
Published: November 2010

AbstractAuch nach vielen Jahren teilweise intensiver Forschung wird die Bestimmung des Querkraftwiderstands von Stahl‐ und Spannbetonträgern in der Fachwelt weiterhin rege diskutiert. Dies liegt einerseits an der Komplexität des Problems, andererseits an der Weiterentwicklung von Bauweisen und Baustoffen sowie den veränderten Fragestellungen. Im vorliegenden Beitrag wird ein dreistufiges Vorgehen präsentiert, das die Bemessung, die Überprüfung und die detaillierte rechnerische Beurteilung von Bauteilen unter Querkrafteinwirkung umfasst. Im Zentrum stehen die Verallgemeinerten Spannungsfelder, die sich insbesondere für die vertiefte Untersuchung und die generelle Überprüfung eines Tragwerks eignen. Die entsprechenden Festlegungen sind durch Versuche gut abgesichert und so aufbereitet, dass sie sich für die Anwendung in der Ingenieurpraxis eignen. Die auf dieser Grundlage ermittelten Querkraftwiderstände werden denjenigen nach den Normen DIN 1045‐1 und Eurocode 2 gegenübergestellt. Es zeigt sich, dass eine Überprüfung der Normvorschriften angebracht wäre. Generell soll der Beitrag zur Diskussion und weiteren Entwicklung der nationalen und internationalen Normen beitragen.Shear Strength of Structural Concrete BeamsEven after many years of in‐depth research, the determination of shear strength of structural concrete beams is still in discussion. The reasons for that are, on the one hand, the complexity of the problem and, on the other hand, further developments of structural systems and building materials as well as new questions arising from the evaluation of existing structures. In this contribution a structured procedure including design, detailed analysis and elaborate assessment of structural concrete members subjected to shear is presented. The focus is on the Generalized Stress Field Approach which particularly enables a profound analysis and a general evaluation of a structure. The corresponding definitions are well supported by experimental results and arranged to be easily used in practical application. Shear strengths calculated on the basis of this method are compared to results according to DIN 1045‐1 and Eurocode 2. It shows that a re‐evaluation of the code provisions is well appropriate. Basically, this contribution may be regarded as a contribution to the discussion about the development of national and international codes.
Die Jahrhunderthalle in Breslau (Wrocław, PL)
Authors: Huber Hannes Sebastian , Mikołajonek Maciej , Filipczak Patryk 
Published: November 2010

AbstractDie Breslauer Jahrhunderthalle zählt zu den größten Meilensteinen auf dem Gebiet des Stahlbetonbaus und beherbergte seit ihrer Eröffnung im Jahre 1913 eine Vielzahl wichtiger Ereignisse. Die Errichtung der multifunktionalen Halle erfolgte innerhalb von nur 15 Monaten und war wegweisend für die damals revolutionäre Technologie der Stahlbetonbauweise. Mit einem Kuppeldurchmesser von 65 m war sie zum Zeitpunkt ihrer Fertigstellung der weltweit größte massive Kuppelbau. Aufgrund der bahnbrechenden Architektur‐ und Konstruktionslösungen wurde die Jahrhunderthalle im Jahre 2006 in die Liste des UNESCO Weltkulturerbes aufgenommen.In den Jahren 2009–2010 erfolgte unter strengen Auflagen des Denkmalamts die erste umfassende Instandsetzung des Bauwerks seit seiner Errichtung. Schäden und Mängel an der Betonfassade und dem Dach wurden behoben und der Zugring durch ein externes Vorspannsystem gesichert. Auch die originalen Holzfenster, die aus nicht mehr existierendem Kazuarholz gefertigt wurden, bedurften einer dringenden Restaurierung. Dank der Wiederherstellung der Originalfarbgebung und Verglasung erstrahlt die Jahrhunderthalle nun erneut im goldgelben Glanz.
Herstellung eines Leitungstunnels unter bestehenden Schleusenanlagen
Authors: Jäppelt Ulrich , Siemke Rainer , Schöner Michael , Fritsch Maik 
Published: November 2010

AbstractIm Zuge einer Grundinstandsetzung an den Brunsbütteler Schleusen war die Herstellung eines Leitungstunnels erforderlich, der die vorhandenen Schleusenanlagen unterquert. Der 455 m lange Leitungstunnel mit einem lichten Durchmesser von 2,20 m muss Medienleitungen aufnehmen und durchgehend begehbar sein. Die Herstellung erfolgte im Rohrvortrieb rd. 36 m unter Gelände. Mittlere Grundwasserstände von rd. 29 m über Tunnelfirste und stetige Schwankungen infolge Tideeinfluss mussten berücksichtigt werden. Im Bereich der Unterfahrung einer hydraulisch offenen Schleusenkammersohle wurden spezielle Sicherungsmaßnahmen gefordert. Einer der Anschlussschächte wurde nach Abschluss des Rohrvortriebs erstellt, in dem die darüber vorhandene Schleuse auf einer Höhe von 25 m mit einer Großbohrung d = 1,80 m durchkernt wurde.
Mechanistic Dichotomy with Alkynes in the Formal Hydrohydrazination/Fischer Indolization Tandem Reaction Catalyzed by a Ph3PAuNTf2/pTSA Binary System
Authors: Patil Nitin T. , Konala Ashok 
Published: November 2010

AbstractAn efficient method involving a formal hydrohydrazination/Fischer indolization tandem reaction to synthesize 2,3‐disubstituted indoles from alkynes and arylhydrazines has been developed. The approach uses a Ph3PAuNTf2/pTSA·H2O binary catalytic system in which a very low catalyst loading of Ph3PAuNTf2 (2 mol‐%) is required. The reaction time is very short and, most importantly, the reaction is not sensitive to moisture. The mechanism of these reactions has been investigated and the results led us to propose an interesting mechanistic dichotomy. When alkynes have OH/COOH groups in the tether, hydroalkoxylation/hydrocarboxylation occurred to generate exocyclic enol ethers/lactones that reacted with hydrazines to produce indoles. In cases where the alkynes lack OH/COOH groups, hydration occurs to generate ketones that react with arylhydrazines to give the desired indoles.
RAE‐1 is expressed in the adult subventricular zone and controls cell proliferation of neurospheres
Authors: Popa Natalia , Cedile Oriane , Pollet‐Villard Xavier , Bagnis Claude , Durbec Pascale , Boucraut José 
Published: November 2010

AbstractImproving and controlling the capacity of endogenous or grafted adult neural stem cells to repair the nervous system relies on a better knowledge of interactions between immune cells and neural stem cells. Class I major histocompatibility complex (MHC) family members comprise numerous proteins playing either immune or nonimmune function. Among the latter, MHC functions in the central nervous system has started to receive recent interest. Here, our first goal was to investigate the potential relationship between MHC class I molecules and neurogenesis. For the first time, we report the expression of two MHC class I‐related members by neural stem/progenitor cells: retinoic acid early induced transcript (RAE)‐1 and CD1d. The expression of RAE‐1 but not CD1d disappears when differentiation of neurosphere cells is induced. Interestingly, RAE‐1 transcripts are expressed in the brain during development, and we demonstrate they persist in one of the main area of adult neurogenesis, the subventricular zone (SVZ). So far, RAE‐1 is only known for its immune functions as a ligand of the activating receptor NKG2D expressed by natural killer (NK) cells, natural killer T, Tγδ, and some T CD8 lymphocytes. Here, we do not detect any NKG2D expression in the SVZ either in physiological or in pathological conditions. Interestingly, inhibition of RAE‐1 expression in neurosphere cells reduces cell proliferation without alteration of cell viability, which argues for a nonimmune role for RAE‐1. These results reveal an unexpected role of RAE‐1 in regulating adult SVZ neurogenesis by supporting stem/progenitor cells proliferation. © 2010 Wiley‐Liss, Inc.
Impact of selected work condition factors on quality of manual assembly process
Authors: Hamrol Adam , Kowalik Dagmara , Kujawińsk Agnieszka 
Published: November 2010

AbstractThis article presents the investigation of selected work environment factors with regard to the quality of manual assembly process. It describes the research carried out in a natural work environment and conditions in a factory producing car wire harnesses. It has been pointed out that only a few work condition factors have a significant influence on the assembly process's quality. The results of the experiments have proved the hypothesis that, between the two important work factors (noise level and work monotony), there is a significant interaction with respect to their impact on the assembly quality process. © 2010 Wiley Periodicals, Inc.
The analytical solution of natural convection in a micro size horizontal cylindrical annulus with periodic volumetric heat flux
Authors: Mansour Kamyar 
Published: November 2010

AbstractWe consider the two‐dimensional problem of steady natural convection in a narrow (micro size) horizontal cylindrical annulus filled with viscous fluid and periodic volumetric heat flux. The solution is expanded in powers of a single combined similarity parameter, which is the product of the gap ratio to the power of four, and Rayleigh number and the series extended by means of symbolic calculation up to 16 terms. Analysis of these expansions allows the exact computation for arbitrary accuracy up to 50,000 figures. Although the range of the radius of convergence is small, the Pade approximation leads our result to be good even for much higher values of the similarity parameter. © 2010 Wiley Periodicals, Inc. Heat Trans Asian Res; Published online in Wiley Online Library (wileyonlinelibrary.com). DOI 10.1002/htj.20323
New Surface‐Directed Vapour Transport Methods for the Controlled Growth of Nickel Sulfide Nanomaterials
Authors: Denholme Saleem J. , Gallagher Jamie B. , Dobson Phillip S. , Weaver John M. R. , Gregory Duncan H. 
Published: November 2010

AbstractHighly symmetrical, isotropic nickel disulfide (NiS2) nanocubes have been synthesised via a Physical Vapour Transport (PVT) method in which sulfur vapour generated in situ is reacted with nickel‐coated silica substrates. Systematic studies demonstrate the effect of the reactant ratio, substrate, metal layer thickness, and reaction temperature on the synthesis and growth process. The evolution of structure and composition has been followed by diffraction and electron microscopy techniques, and the size of the NiS2 cubes can be varied from below 200 nm to 1–2 μm across. Magnetic properties of the disulfide nanomaterials have been determined using SQUID magnetometry. Initial experiments also demonstrate that related Chemical Vapour Transport (CVT) techniques can be exploited to produce alternative compositions in the Ni–S system with varying morphologies that can be controlled via chemical and physical reaction parameters.
Long‐term trends and variability in measured multi‐spectral aerosol optical depth over a tropical urban station in India
Authors: Dani K. K. , Ernest Raj P. , Devara P. C. S. , Pandithurai G. , Sonbawne S. M. , Maheskumar R. S. , Saha S. K. , Jaya Rao Y. 
Published: November 2010

AbstractSun photometer‐derived multi‐spectral aerosol optical depth (AOD) measurements made at Pune (18°32′N, 73°51′E), India, during the period May 1998–December 2007 have been used to examine possible long‐term trends and variability. Long‐term mean AOD in the spectral range 380–1020 nm ranged between 0.593 ± 0.11 and 0.220 ± 0.04 with a coefficient of variation (COV) of 34–49%. Day‐to‐day variations in AOD at all the wavelengths in the range 380–870 nm showed significant long‐term increasing trends; the increasing trend at 380 nm being 45% per decade. AODs are higher at shorter wavelengths in winter (December–February) and at longer wavelengths in the pre‐monsoon months (March–May) which implies that relatively smaller‐sized particles are more in winter and larger sized particles of soil dust origin are more during the pre‐monsoon season. Overall mean value of Angstrom‐size exponent (α) at this urban location is 0.55, and the mean turbidity coefficient (β) is 0.76. Value of α is higher in winter season compared to the pre‐monsoon season. Both α and β show long‐term increasing trends of 25.3% and 8.4% per decade, respectively, which points out that with increasing urbanisation and human activity, more and more smaller‐sized aerosols are being added to the atmosphere over the urban regions. Copyright © 2010 Royal Meteorological Society
Neuromuscular morphometry of the uterine ligaments and vaginal wall in women with pelvic organ prolapse
Authors: Kaplan Petek Balkanlı , Usta Ufuk , Inal Hasan Ali , Tastekin Tugba , Tokuc Burcu 
Published: November 2010

AbstractAimsThe aim of this study was to compare neuromuscular histomorphometry of the uterine ligaments and vaginal wall in women with and without pelvic organ prolapse.MethodsBiopsies were obtained from the round, uterosacral, and cardinal ligaments of the uterus and apical vaginal wall of women having pelvic organ prolapse repaired (stage ≥ II; prolapse group, 37) and the same location in patients with no prolapse (stage < II; control group, 47). Routine hematoxylin–eosin (H & E) staining and immunohistochemical staining for Protein Gene Product 9.5 (PGP 9.5) and smooth muscle α‐actin were performed for all specimens.ResultsSmooth muscle percentage of the uterosacral and cardinal ligaments were not significantly different in women with prolapse than in women without. In round ligament, mean smooth muscle percentage was lower than in women with normal support (81.63 ± 8.2 vs. 51.63 ± 16, P = 0.000). Mean distance of the smooth muscle fibers from surface epithelium of the vaginal epithelium of the women with prolapse were significantly higher than the control group (1.679 ± 0.34 vs. 2.240 ± 0.33, P = 0.000). PGP 9.5 stained area percentage of uterine ligaments and vaginal wall tissue samples were significantly lower in women with prolapse.ConclusionsBoth total innervation of the anterior vaginal epithelium and uterine ligaments, and muscular percentage of the round ligament and vaginal wall were decreased in women with pelvic organ prolapse. Neurourol. Urodynam. 30:126–132, 2011. © 2010 Wiley‐Liss
Characterizing the proteome of the human dorsolateral prefrontal cortex by shotgun mass spectrometry
Authors: Martins‐de‐Souza Daniel , Guest Paul C. , Steeb Hannah , Pietsch Sandra , Rahmoune Hassan , Harris Laura W. , Bahn Sabine 
Published: November 2010

AbstractThe studies of neuropsychiatric disorders would be facilitated by enhanced knowledge of the dorsolateral prefrontal cortex (DLPFC) proteome. To construct a data set of human DLPFC proteins, protein extracts were prepared from 12 postmortem brains focussing on the DLPFC region (Brodmann area 9) and analyzed using a combined gel electrophoresis and shotgun mass spectrometry approach, featuring data‐independent label‐free nanoflow liquid chromatography mass spectrometry (nLC‐MSE). The detected mass/time features were aligned and annotated using the results from ProteinLynx Global Server. The resulting data set comprised 488 unique and accurately identified proteins, with stringent identification by a minimum of two distinct peptides detected at least in >75% of samples. These proteins were involved predominantly in cytoskeletal architecture, metabolism, transcription/translation, and synaptic function. Combination of this data set with that obtained by our previous characterization of the same brain region results in a total of 755 unique proteins, making this the most comprehensive analysis of this important brain region to date.