bluuebunny/crossref_metadata_2025_split huggingface dataset:
Exploring the uncharted territory of the potential protein–protein interactions of cytosolic malate dehydrogenase
Authors: Provost Joseph J. , Parente Amy D. , Slade Kristin M. , Wiese Thomas J. 
Published: June 2024

Abstract
In this review, we examine the protein–protein interactions of cytosolic malate dehydrogenase (MDH), an under-studied area in cellular metabolism. We provide a comprehensive overview of MDH involvement in metabolism, especially its interactions with metabolic partners and dynamics of changing metabolism. We present an analysis of the biophysical nature of these interactions and the current methods used to study them. Our review includes an assessment of computational docking studies, which offer initial hypotheses about potential MDH interaction partners. Furthermore, we provide a summary of the sparse yet insightful experimental evidence available, establishing a foundation for future research. By integrating biophysical analysis and methodological advancements, this paper aims to illuminate the intricate network of interactions involving cytosolic MDH and their metabolic implications. This work not only contributes to our understanding of MDH’s role in metabolism but also highlights the potential impact of these interactions in metabolic disorders.
From poverty to prosperity: assessing of sustainable poverty reduction effect of “welfare-to-work” in Chinese counties
Authors: Lan Feng , Xu Weichao , Sun Weizeng , Zhao Xiaonan 
Published: June 2024

AbstractThe “welfare-to-work” program is a comprehensive supportive policy in the 14th five-year plan period in China. In this paper, a systematical assessment of the long-run effectiveness of the welfare-to-work policy on poverty reduction is of great significance to stimulate the internal impetus of people who are lifted out of poverty to achieve income growth and prosperity and promote regional economic development. Based on the data at the county (city) level in China from 2000 to 2019 and the sustainable development theory, in this paper, a county-relative poverty evaluation system was constructed. Besides, the double difference method was employed to evaluate the effect of the welfare-to-work policy on poverty reduction and test its action mechanism. The findings are as follows: (1) the welfare-to-work policy has a significant poverty reduction effect and presents an inverted “U” shape. In addition, significant achievements have been made in “maintaining employment stability, ensuring income, strengthening skills, and supporting the economy” ; (2) the welfare-to-work policy boosts poverty reduction in counties through infrastructure construction, fiscal intervention, and financial tools; however, the financial tools play a positive role in poverty reduction in the northwest region and suppressed role in the southwest region, and has an insignificant effect in the central region; and (3) there are differences in the effect of poverty alleviation policies of the counties with different sustainable development levels, and the regions with higher development level have a stronger driving effect.
‘The benefits of the vaccine outweigh the risks… they say’
Authors: Riccioni Ilaria , Bertolazzi Alessia , Bongelli Ramona 
Published: June 2024

Abstract
This study aims to analyse Italian Internet users’ comments on two posts that appeared on the Facebook page of the
Italian newspaper Il Corriere della Sera during a particularly critical phase of the COVID-19 pandemic
(specifically, March 2021). At that time, the AstraZeneca vaccine had been temporarily suspended in some European countries due to
confirmed reports of blood clots but subsequently declared “safe and effective” by the European Medicines Agency. Two datasets of
comments were collected and analysed by combining automatic and manual, as well as quantitative and qualitative, methods. The main
findings shed light on the orientation (agreement vs disagreement), construction of consensus and dissent, and epistemic
positioning of Facebook users when they are confronted and engaged in dialogue with uncertain news about public health issues.
New features in Franck–Hertz experiment with argon: experiment and Monte Carlo simulation
Authors: Dong Tianzuo , Wang Yanqi , Zhang Yi , Shi Qingtian , Dai Rucheng , Sun Xiaoyu , Wang Zhongping , Zhang Zengming , Sun Lazhen 
Published: June 2024

Abstract
In this work, a homemade apparatus was built to perform the Franck–Hertz experiment with argon. The lowest energy state and the higher energy state of argon can be excited by the Franck–Hertz experiment. The excitation energies of the argon atom are measured by using the setup. The obtained higher excitation energy of argon atoms is 13.73 ± 0.28 eV, for the mixture of higher energy states 3s
23p
53d and 3s
23p
54p. A plate capacitor model was constructed to simulate the inelastic collisions between electrons and argon atoms using the Monte Carlo method. The simulated current curve and electron energy distribution agrees with that of Franck–Hertz experiments, especially the features of higher excited state. The Monte Carlo simulation indicates the deformed electron energy distribution results from the change in excitation proportion of energy levels during the collisions of electrons and argon atoms. Moreover, the new features in Franck–Hertz curve are ascribed to the higher excitation states of argon atoms. The experimental setup has been applied to undergraduate physics experiment teaching in college. Students can perform the Franck–Hertz curve measurement of not only the lowest excited state, but also the higher excited states of argon. In addition, students can do the Monte Carlo simulations for the experimental Franck–Hertz curves and gain a better understanding of electron-argon atom collisions in the experiment. The new designed experiment will make students more familiar with the quantum behavior in atomic physics and quantum mechanics course.
GaN-based E-mode p-FETs with polarization-doped p-type graded AlGaN channels
Authors: Xing Zhanyong , Zhang Haochen , Ye Yankai , Liang Fangzhou , Yang Lei , Huang Zhe , Liang Kun , Wang Hu , Zhang Mingshuo , Li Jiayao , Zuo Chengjie , Sun Haiding 
Published: June 2024

Abstract
Herein, a novel enhancement-mode (E-mode) GaN-based p-channel FETs (p-FETs) with a linearly graded AlGaN (LGA) p-channel is proposed and numerically studied by Silvaco TCAD. Thanks to strong polarization-induced doping, three-dimensional hole gas (3DHG) can be uniformly generated in LGA to form a continuous p-channel with a hole concentration over 1018 cm–3. Combined with an optimized recessed gate structure, the LGA p-FET can simultaneously achieve a large threshold voltage (|V
TH|) > 2 V and a high current density (|J
DS|) of ∼10 mA mm−1 at V
DS = −10 V. Additionally, two critical parameters of the LGA p-FETs, i.e. the depth of recessed gate and initial Al composition of LGA, are specifically studied to reveal the unique carrier behavior of 3DHG in the devices. Importantly, the LGA structure is further optimized and implemented as the p-type cap layer to construct an E-mode GaN n-FET. Thereby, based on the same LGA configuration, a GaN-based inverter with the matched complementary n- and p-FETs is monolithically constructed, showing sharp voltage transition. The reported novel LGA structure and its availability in both GaN-based E-mode n- and p-FETs provides valuable insights and guidance to construct highly efficient GaN p-type devices and All-GaN-based integrated circuits for compact power electronic systems.
Tunable metamaterials with carrier-induced effective permittivity for active control of electromagnetic fields in semiconductor manufacturing device
Authors: Lee Minyeul , Yoon Sungyoung , Lim Meehyun , Kim Sungyeol , Shin Jonghwa 
Published: June 2024

Abstract
Precise control of electromagnetic fields is critical in many advanced manufacturing processes, such as those used in the semiconductor industry, where device performance relies on precision and uniformity. Here, we introduce a solution to control electromagnetic fields via permittivity modulation without the limitations of resonance-based approaches, through a patterned semiconductor enabling permittivity tuning via carrier-density modulation. This carrier-responsive metamaterial (CRM) exhibits frequency-independent performance over a broad frequency spectrum and significant permittivity tunability through controlled semiconductor conductivity. Furthermore, the conductivity response and the tuning range can be easily modulated through the variation of semiconductor materials and geometrical parameters. We present an intuitive model that explains the relationship between the CRM’s structure and properties, including its effective permittivity and loss tangent. Supported by comprehensive simulations and experimental validations, our findings show that the effective permittivity can be increased by over 3.5 times with low dielectric loss across a wide frequency range. As an application, we explore the CRM’s potential in plasma control, revealing its ability to influence plasma density nearly 30% by modulating its effective permittivity, exhibiting CRM’s versatile functionality and potential impact across diverse technological domains.
Efficacy of barium and calcium additives in lithium silicate glasses for nuclear shielding applications
Authors: Yilmaz Alan Hatice 
Published: June 2024

Abstract
This study presents a detailed investigation into the nuclear radiation shielding capabilities of lithium silicate (Li2O-SiO2) glass systems, specifically examining the impact of doping with barium oxide (BaO) and calcium oxide (CaO). Utilizing advanced simulation tools, including PAGEX and SRIM for charged particle interactions, and Phy-X/PSD for gamma-ray attenuation analysis, the radiation shielding effectiveness of BaO-based and CaO-based lithium silicate glasses were systematically compared. The gamma attenuation parameters (LAC, MAC, TVL, HVL, EBF, EABF, MFP, Zeff, Neff, FNRCS, and Zeq) of investigated glass samples were computed via the Phy-X/PSD program (15 keV-15 MeV energy). The HVL values vary between 0.007–14.203 cm, and the TVL values vary between 0.054–47.182 cm for all samples in the selected energy range. The highest and lowest values of FNRCS were observed for samples BaO20 and CaO5, with the values 0.093 and 0.1 cm−1, respectively. KERMAs were calculated using PAGEX software between the 1.5 keV and 20 MeV energy range, with the highest KERMA obtained for the BaO20 sample at 0.05 MeV and the lowest KERMA obtained for the CaO5 sample at the lowest density. The mass stopping power quantities were computed between 1 keV-10 GeV energy with PAGEX. The projected range values were calculated with SRIM codes. The lowest projected range values for both alpha particles and protons were obtained for the BaO20 sample with maximum density (3.391 g cm−3). The sample with BaO20 code showed better shielding potential for alpha and proton particles with lower values of projected range and mass stopping power. Findings reveal that the Li2O-BaO-SiO2 glass composition exhibits superior gamma-ray attenuation properties compared to its CaO-doped counterpart, with the BaO20 sample demonstrating particularly enhanced performance.
The hyperbolic sine chaotification model and its applications
Authors: Li Binglun , Sun Kehui , Wang Huihai , Liu Wenhao 
Published: June 2024

Abstract
Some existing chaotic systems suffer from issues such as period windows, discontinuous parameter ranges, and dynamical degradation, which seriously limit their application. Therefore, designing high-performance anti-degradation chaotic systems is of great significance. In this paper, a novel hyperbolic sine chaotification model (HSCM) is proposed. It allows for the use of any chaotic maps or linear functions as the seed maps, and employs a closed-loop modulation coupling (CMC) method to extend it to high-dimensional (HD) chaotic maps. Theoretical and experimental results show that this model can effectively improve the Lyapunov exponent (LE) of the seed chaotic map and expand the parameter ranges. In addition, it can also resist the dynamical degradation under finite computational precision. Based on the HSCM, a novel eight-dimensional (8D) HSCM is designed, and implemented through field-programmable gate array (FPGA) in both serial and parallel modes, respectively. Furthermore, the novel chaotic maps are applied to pseudo-random sequence generator (PRNG) and image compression under finite computing precision. Experimental results indicate that the novel chaotification model has greatly broad application prospects.
Dynamics of holographic images of scalar-tensor-vector gravity-AdS black holes*
Authors: Hu 胡 Xin-Yun 馨匀 , Aslam M. Israr , Saleem Rabia , Zeng 曾 Xiao-Xiong 晓雄 
Published: June 2024

Abstract
Using AdS/CFT correspondence, we analyze the holographic Einstein images via the response function of the complex scalar field as a probe wave on an AdS Schwarzschild scalar-tensor-vector gravity (STVG) black hole (BH). We find that the amplitude of the response function

decreases with increasing values of coupling parameter α and increases with decreasing temperature T. The frequency ω of the wave source also plays a significant role in wave periods; as we increase the values of ω, the periods of waves decrease, indicating that the total response function closely depends on the wave source. Further, we investigate the optical appearance of the holographic images of the BH in bulk. We found that the holographic ring always appears with surrounding concentric stripes when the observer is located at the north pole, and an extremely bright ring appears when the observer is at the position of the photon sphere of the BH. This ring changes into a luminosity-deformed ring or a bright light spot as the observational angle changes. The corresponding brightness profiles show that the luminosity of the ring decreases and the shadow radius increases with increasing values of α. The relation between temperature T and the inverse of the horizon

is discussed; T is small at the beginning of the horizon

and then increases as the horizon radius increases. This effect can be used to distinguish the STVG BH solution from other BH solutions. Moreover, these significant features are also reflected in the Einstein ring and corresponding brightness profiles. In addition, we compare the results obtained by wave optics and geometric optics, which align well, implying that the holographic scheme adopted in this study is valid.
Gulistan in Black and White
Authors: Pourtavaf Leila 
Published: June 2024

Abstract
This paper takes the late Qajar court and harem as a historically specific site through which we can examine the complex and diverse histories of slavery within the region in the nineteenth century, as well as the ways in which hierarchies of race, gender, and sex functioned as constitutive elements of this institution. I examine a particular albeit very elite site, Nasir al-Din Shah’s harem, occupied by a variety of enslaved and formerly enslaved constituents who were a product of the evolving slave trade. The essay ends by zooming in on the lives (and afterlives) of two eunuchs, Aziz Khan and Agha Bahram, who were part of the servant class of Gulistan Palace during Nasir al-Din Shah’s reign, and whose life trajectories offer us some insight into the racial and gendered legacies of late nineteenth-century slavery in Iran.
The MATH test. A three-phase assay?
Authors: Salas-Tovar Jesús A , Escobedo-García Sarai , Olivas Guadalupe I , Acosta-Muñiz Carlos H , Harte Federico , Sepulveda David R 
Published: June 2024

Abstract
This study aimed to investigating the possible interference caused by glass test tubes on the quantification of bacterial adhesion to hydrocarbons by the MATH test. The adhesion of four bacteria to hexadecane and to glass test tubes was evaluated employing different suspending polar phases. The role of the ionic strength of the polar phase regarding adhesion to glassware was investigated. Within the conditions studied, Gram-positive bacteria adhered to both the test tube and the hydrocarbon regardless of the polar phase employed; meanwhile, Escherichia coli ATCC 25922 did not attach to either one. The capacity of the studied microorganisms to adhere to glassware was associated with their electron-donor properties. The ionic strength of the suspending media altered the patterns of adhesion to glass in a strain-specific manner by defining the magnitude of electrostatic repulsion observed between bacteria and the glass surface. This research demonstrated that glass test tubes may interact with suspended bacterial cells during the MATH test under specific conditions, which may lead to overestimating the percentage of adhesion to hydrocarbons and, thus, to erroneous values of cell surface hydrophobicity.
Selection Shapes the Genomic Landscape of Introgressed Ancestry in a Pair of Sympatric Sea Urchin Species
Authors: Glasenapp Matthew R , Pogson Grant H 
Published: June 2024

Abstract
A growing number of recent studies have demonstrated that introgression is common across the tree of life. However, we still have a limited understanding of the fate and fitness consequence of introgressed variation at the whole-genome scale across diverse taxonomic groups. Here, we implemented a phylogenetic hidden Markov model to identify and characterize introgressed genomic regions in a pair of well-diverged, nonsister sea urchin species: Strongylocentrotus pallidus and Strongylocentrotus droebachiensis. Despite the old age of introgression, a sizable fraction of the genome (1% to 5%) exhibited introgressed ancestry, including numerous genes showing signals of historical positive selection that may represent cases of adaptive introgression. One striking result was the overrepresentation of hyalin genes in the identified introgressed regions despite observing considerable overall evidence of selection against introgression. There was a negative correlation between introgression and chromosome gene density, and two chromosomes were observed with considerably reduced introgression. Relative to the nonintrogressed genome-wide background, introgressed regions had significantly reduced nucleotide divergence (dXY) and overlapped fewer protein-coding genes, coding bases, and genes with a history of positive selection. Additionally, genes residing within introgressed regions showed slower rates of evolution (dN, dS, dN/dS) than random samples of genes without introgressed ancestry. Overall, our findings are consistent with widespread selection against introgressed ancestry across the genome and suggest that slowly evolving, low-divergence genomic regions are more likely to move between species and avoid negative selection following hybridization and introgression.
GWAS Identifies DPP6 as Risk Gene of Cognitive Decline in Parkinson’s Disease
Authors: Li Chunyu , Hou Yanbing , Ou Ruwei , Wei Qianqian , Zhang Lingyu , Liu Kuncheng , Lin Junyu , Chen Xueping , Song Wei , Zhao Bi , Wu Ying , Shang Huifang 
Published: June 2024

Abstract

Background
Cognitive decline is among the most common non-motor symptoms in Parkinson’s disease (PD), while its physiological mechanisms remain poorly understood. Genetic factors constituted a fundamental determinant in the heterogeneity of cognitive decline among PD patients. However, the underlying genetic background was still less studied.

Methods
To explore the genetic determinants contributing to cognitive decline in PD, we performed genome-wide survival analysis using a Cox proportional hazards model in a longitudinal cohort of 450 Chinese patients with PD, and further explored the functional effect of the target variant. Additionally, we built a clinical-genetic model by incorporating clinical characteristics and polygenic risk score (PRS) to predict cognitive decline in PD.

Results
The cohort was followed up for an average of 5.25 (SE = 2.46) years, with 95 incidents of cognitive impairment. We identified significant association between locus rs75819919 (DPP6) and accelerated cognitive decline (p = 8.63E-09, beta = 1.74, SE = 0.30). Dual-luciferase reporter assay suggested this locus might be involved in the regulation of DPP6 expression. Using data set from the UK Biobank, we identified rs75819919 was associated with cognitive performance in the general population. Incorporation of PRS increased the model’s predictability, achieving an average AUC of 75.6% through fivefold cross-validation in 1 000 iterations.

Conclusions
These findings improve the current understanding of the genetic etiology of cognitive impairment in PD, and provide a novel target DPP6 to explore therapeutic options. Our results also demonstrate the potential to develop clinical-genetic model to identify patients susceptible to cognitive impairment and thus provide personalized clinical guidance.
Dolutegravir- Versus Efavirenz-Based Treatment in Pregnancy: Impact on Red Blood Cell Folate Concentrations in Pregnant Women and Their Infants
Authors: Jacobson Denise L , Crider Krista S , DeMarrais Patricia , Brummel Sean , Zhang Mindy , Pfeiffer Christine M , Moore Cynthia A , McCarthy Katie , Johnston Benjamin , Mohammed Terence , Vhembo Tichaona , Kabugho Enid , Muzorah Gerald Agaba , Cassim Haseena , Fairlie Lee , Machado Elizabeth S , Ngocho James S , Shapiro Roger L , Serghides Lena , Chakhtoura Nahida , Chinula Lameck , Lockman Shahin 
Published: June 2024

Abstract

Background
In the International Maternal Pediatric Adolescent AIDS Clinical Trials (IMPAACT) 2010/VESTED study, pregnant women were randomized to initiate dolutegravir (DTG) + emtricitabine (FTC)/tenofovir alafenamide (TAF), DTG + FTC/tenofovir disoproxil fumarate (TDF), or efavirenz (EFV)/FTC/TDF.

Methods
We assessed red blood cell (RBC) folate concentrations at maternal study entry and delivery, and infant birth. RBC folate outcomes were (1) maternal change entry to delivery (trajectory), (2) infant, and (3) ratio of infant-to-maternal delivery. Generalized estimating equation models for each log(folate) outcome were fit to estimate adjusted geometric mean ratio (Adj-GMR)/GMR trajectories (Adj-GMRTs) of each arm comparison in 340 mothers and 310 infants.

Results
Overall, 90% of mothers received folic acid supplements and 78% lived in Africa. At entry, median maternal age was 25 years, gestational age was 22 weeks, CD4 count was 482 cells/μL, and log10 HIV RNA was 3 copies/mL. Entry RBC folate was similar across arms. Adj-GMRT of maternal folate was 3% higher in the DTG + FTC/TAF versus EFV/FTC/TDF arm (1.03 [95% confidence interval {CI}, 1.00–1.06]). The DTG + FTC/TAF arm had an 8% lower infant-maternal folate ratio (0.92 [95% CI, .78–1.09]) versus EFV/FTC/TDF.

Conclusions
Results are consistent, with no clinically meaningful differences between arms for all RBC folate outcomes, and they suggest that cellular uptake of folate and folate transport to the infant do not differ in pregnant women starting DTG- versus EFV-based antiretroviral therapy.

Clinical Trials Registration
NCT03048422.