bluuebunny/crossref_metadata_2025_split huggingface dataset:
Responses to Adalimumab in Patients with Active Psoriatic Arthritis Who Have Not Adequately Responded to Prior Therapy: Effectiveness and Safety Results From an Open-label Study
Authors: GLADMAN DAFNA D. , SAMPALIS JOHN S. , ILLOUZ OLIVIER , GUÉRETTE BENOÎT 
Published: July 2010

Objective.To evaluate the effectiveness and safety of adalimumab in patients with active psoriatic arthritis (PsA) and an inadequate response to prior therapy.Methods.Patients were treated with subcutaneous injections of adalimumab 40 mg every other week in addition to their standard antirheumatic therapies in a 12-week, open-label study. Effectiveness evaluations at Week 12 included American College of Rheumatology (ACR) and Psoriasis Area and Severity Index (PASI) response rates, Psoriatic Arthritis Response Criteria (PsARC), active dactylitis, enthesitis, and target lesion assessment. Physical function was evaluated using the Health Assessment Questionnaire Disability Index (HAQ-DI).Results.A total of 127 patients were enrolled. At Week 12, patients achieved ACR20, ACR50, and ACR70 response rates of 78.0%, 55.9%, and 21.3%, respectively. PASI50 and PASI75 response rates were 64.7% and 47.1%. A PsARC response was experienced by 70.1% of patients. Between baseline and Week 12, clinically and statistically significant reductions occurred in the mean total plaque score of the target lesion as well as in the percentages of patients with active dactylitis and enthesitis. A mean improvement in HAQ-DI was also observed (−0.44; p < 0.001). Three serious adverse events were reported, but none was considered related to adalimumab therapy.Conclusion.Adalimumab-treated patients achieved significant improvements in both skin and joint manifestations of PsA, as well as in physical function. Adalimumab was well tolerated and had a safety profile similar to that observed in other clinical trials of adalimumab for the treatment of PsA. ClinicalTrials.gov identifier: NCT00427362.
Implications for Gene Therapy-Limiting Expression of IL-2Rγc Delineate Differences in Signaling Thresholds Required for Lymphocyte Development and Maintenance
Authors: Orr Selinda J. , Roessler Stephen , Quigley Laura , Chan Tim , Ford Jill W. , O’Connor Geraldine M. , McVicar Daniel W. 
Published: July 2010

Abstract
X-linked SCID patients are deficient in functional IL-2Rγc leading to the loss of IL-2/IL-4/IL-7/IL-9/IL-15/IL-21 signaling and a lack of NK and mature T cells. Patients treated with IL-2Rγc gene therapy have T cells develop; however, their NK cell numbers remain low, suggesting antiviral responses may be compromised. Similarly, IL-2Rγc−/− mice reconstituted with IL-2Rγc developed few NK cells, and reconstituted T cells exhibited defective proliferative responses suggesting incomplete recovery of IL-2Rγc signaling. Given the shift toward self-inactivating long terminal repeats with weaker promoters to control the risk of leukemia, we assessed NK and T cell numbers and function in IL-2Rγc−/− mice reconstituted with limiting amounts of IL-2Rγc. Reconstitution resulted in lower IL-2/-15–mediated STAT5 phosphorylation and proliferation in NK and T cells. However, TCR costimulation restored cytokine-driven T cell proliferation to wild-type levels. Vector modifications that improved IL-2Rγc levels increased cytokine-induced STAT5 phosphorylation in both populations and increased NK cell proliferation demonstrating that IL-2Rγc levels are limiting. In addition, although the half-lives of both NK and T cells expressing intermediate levels of IL-2Rγc are reduced compared with wild-type cells, the reduction in NK cell half-live is much more severe than in T cells. Collectively, these data indicate different IL-2Rγc signaling thresholds for lymphocyte development and proliferation making functional monitoring imperative during gene therapy. Further, our findings suggest that IL-2Rγc reconstituted T cells may persist more efficiently than NK cells due to compensation for suboptimal IL-2Rγc signaling by the TCR.
Herpes Simplex Virus Type 2 Enhances HIV-1 Susceptibility by Affecting Langerhans Cell Function
Authors: de Jong Marein A. W. P. , de Witte Lot , Taylor Maureen E. , Geijtenbeek Teunis B. H. 
Published: July 2010

Abstract
Genital herpes is the most prevalent viral sexually transmitted infection worldwide and is mainly caused by HSV type 2 (HSV-2). HSV-2 infection enhances HIV-1 susceptibility, even in the absence of clinical symptoms. In this study, we investigated the effect of HSV-2 on HIV-1 transmission by mucosal Langerhans cells (LCs). LCs are important in heterosexual transmission because they form a barrier against HIV-1 infection; LCs efficiently capture and degrade HIV-1 through the C-type lectin langerin, thereby preventing HIV-1 transmission. Notably, our data showed that HSV-2 enhanced HIV-1 infection of LCs and subsequent HIV-1 transmission to T cells. HSV-2 interfered with HIV-1 capture by langerin, which allowed efficient HIV-1 infection of LCs. HSV-2 inhibited the antiviral function of langerin at two levels; HSV-2 decreased langerin expression and competed with HIV-1 for langerin binding. HSV-2 replication was not required, because both UV-inactivated HSV-2 and TLR-3 agonist polyinosinic:polycytidylic acid similarly increased HIV-1 transmission by LCs. Therefore, we identified a mechanism by which HSV-2 enhances HIV-1 susceptibility, even in the absence of clinical symptoms. Our data demonstrated that viral coinfections, such as HSV-2, breach the protective function of LCs by abrogating langerin function, which increases HIV-1 susceptibility. These data reinforce the importance of preventing sexually transmitted infections, such as HSV-2, to reduce the transmission of HIV-1.
T Cell Activation Leads to Protein Kinase Cθ-Dependent Inhibition of TGF-β Signaling
Authors: Giroux Martin , Delisle Jean-Sébastien , O’Brien Alan , Hébert Marie-Josée , Perreault Claude 
Published: July 2010

Abstract
TGF-β is an ubiquitous cytokine that plays a pivotal role in the maintenance of self-tolerance and prevention of immunopathologies. Under steady-state conditions, TGF-β keeps naive T cells in a resting state and inhibits Th1 and Th2 cell differentiation. Because rapid generation of Th1 and Th2 effector cells is needed in response to pathogen invasion, how do naive T cells escape from the quiescent state maintained by TGF-β? We hypothesized that stimulation by strong TCR agonists might interfere with TGF-β signaling. Using both primary mouse CD4+ T cells and human Jurkat cells, we observed that strong TCR agonists swiftly suppress TGF-β signaling. TCR engagement leads to a rapid increase in SMAD7 levels and decreased SMAD3 phosphorylation. We present evidence that TCR signaling hinders SMAD3 activation by inducing recruitment of TGF-βRs in lipid rafts together with inhibitory SMAD7. This effect is dependent on protein kinase Cθ, a downstream TCR signaling intermediary, as revealed by both pharmacological inhibition and expression of dominant-negative and constitutively active protein kinase Cθ mutants. This work broadens our understanding of the cross-talk occurring between the TCR and TGF-β signaling pathways and reveals that strong TCR agonists can release CD4 T cells from constitutive TGF-β signaling. We propose that this process may be of vital importance upon confrontation with microbial pathogens.
Polymorphic Variants of LIGHT (TNF Superfamily-14) Alter Receptor Avidity and Bioavailability
Authors: Cheung Timothy C. , Coppieters Ken , Sanjo Hideki , Oborne Lisa M. , Norris Paula S. , Coddington Amy , Granger Steven W. , Elewaut Dirk , Ware Carl F. 
Published: July 2010

Abstract
The TNF superfamily member homologous to lymphotoxins, exhibits inducible expression, and competes with HSV glycoprotein D for herpesvirus entry mediator (HVEM), a receptor expressed by T lymphocytes (LIGHT) [TNF superfamily (SF)-14], is a key cytokine that activates T cells and dendritic cells and is implicated as a mediator of inflammatory, metabolic, and malignant diseases. LIGHT engages the lymphotoxin-β receptor (LTβR) and HVEM (TNFRSF14), but is competitively limited in activating these receptors by soluble decoy receptor-3 (DcR3; TNFRSF6B). Two variants in the human LIGHT alter the protein at E214K (rs344560) in the receptor-binding domain and S32L (rs2291667) in the cytosolic domain; however, the functional impact of these polymorphisms is unknown. A neutralizing Ab failed to bind the LIGHT-214K variant, indicating this position as a part of the receptor-binding region. Relative to the predominant reference variant S32/E214, the other variants showed altered avidity with LTβR and less with HVEM. Heterotrimers of the LIGHT variants decreased binding avidity to DcR3 and minimized the inhibitory effect of DcR3 toward LTβR-induced activation of NF-κB. In patients with immune-mediated inflammatory diseases, such as rheumatoid arthritis, DcR3 protein levels were significantly elevated. Immunohistochemistry revealed synoviocytes as a significant source of DcR3 production, and DcR3 hyperexpression is controlled by posttranscriptional mechanisms. The increased potential for LTβR signaling, coupled with increased bioavailability due to lower DcR3 avidity, provides a mechanism of how polymorphic variants in LIGHT could contribute to the pathogenesis of inflammatory diseases.
Fiber formation of a synthetic spider peptide derived from Nephila clavata
Authors: Hidaka Yuji , Kontani Ko‐Ichi , Taniguchi Rina , Saiki Masatoshi , Yokoi Sayoko , Yukuhiro Kenji , Yamaguchi Hiroshi , Miyazawa Mitsuhiro 
Published: July 2010

AbstractDragline silk is a high‐performance biopolymer with exceptional mechanical properties. Artificial spider dragline silk is currently prepared by a recombinant technique or chemical synthesis. However, the recombinant process is costly and large‐sized synthetic peptides are needed for fiber formation. In addition, the silk fibers that are produced are much weaker than a fiber derived from a native spider. In this study, a small peptide was chemically synthesized and examined for its ability to participate in fiber formation. A short synthetic peptide derived from Nephila clavata was prepared by a solid‐phase peptide method, based on a prediction using the hydrophobic parameter of each individual amino acid residue. After purification of the spider peptide, fiber formation was examined under several conditions. Fiber formation proceeded in the acidic pH range, and larger fibers were produced when organic solvents such as trifluoroethanol and acetonitrile were used at an acidic pH. Circular dichroism measurements of the spider peptide indicate that the peptide has a β‐sheet structure and that the formation of a β‐sheet structure is required for the spider peptide to undergo fiber formation. © 2010 Wiley Periodicals, Inc. Biopolymers (Pept Sci) 96: 222‐227, 2011.
ChemInform Abstract: The Crystal Structure of YPdSi, the Isotypic Compounds LnPdSi (Ln: Gd—Lu), and Their Structural Relation to Some Other Equiatomic Compounds of the Rare Earth and Transition Metals with Main Group Elements.
Authors: PROTS' Y. M. , POETTGEN R. , JEITSCHKO W. 
Published: July 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Chalcogenide Distribution in Microporous Layered Tin(IV) Thioselenide, TMA2Sn3SxSe7‐x, Materials.
Authors: AHARI H. , DAG OE. , PETROV S. , OZIN G. A. , BEDARD R. L. 
Published: July 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: [NBu4n]4 [(Re6S5OCl7)2O], an Oxo‐Bridged Siamese Twin Cluster of Two Hexanuclear Oxochalcohalide Rhenium Clusters.
Authors: SIMON F. , BOUBEKEUR K. , GABRIEL J.‐C. P. , BATAIL P. 
Published: July 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis and X‐Ray Diffraction Study of Nd1.4Ln0.2Sr0.4Ni1‐x CuxO4 .+‐. δ (Ln: Ce, Pr; 0 ≤ x ≤ 1) Solid Solutions.
Authors: NEDIL'KO S. A. , LISHKO T. P. , MANCHENKO O. F. 
Published: July 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Condensed‐Phase Transitions During Effusion of Gallium Selenide.
Authors: VISWANATHAN R. , EDWARDS J. G. 
Published: July 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Acidity of Substituted Mesoporous Molecular Sieve MCM‐48.
Authors: LANDMESSER H. , KOSSLICK H. , KUERSCHNER U. , FRICKE R. 
Published: July 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: A Naphthalene‐Like Si1010‐ Unit in the Novel ∞2[Si2030‐] Planar Anion of Sr13Mg2Si20.
Authors: CURRAO A. , NESPER R. 
Published: July 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis, Structure, and Properties of Zirconium Trivalent Metal (Al, Fe) Phosphates.
Authors: EGOR'KOVA O. V. , ORLOVA A. I. , PET'KOV V. I. 
Published: July 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: The Room Temperature Conversion of Nickel Difluoride to Hexafluoronickelate(IV) Salts of Alkali Cations.
Authors: WHALEN J. M. , LUCIER G. M. , CHACON L. , BARTLETT N. 
Published: July 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Strain Effects in Protonated Carbonyl Compounds. An Experimental and ab initio Treatment of Acyclic Carboxamides and Ketones
Authors: ABBOUD J.‐L. M. , ET AL. ET AL. 
Published: July 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: P‐Chiral Bis(trialkylphosphine) Ligands and Their Use in Highly Enantioselective Hydrogenation Reactions.
Authors: IMAMOTO T. , WATANABE J. , WADA Y. , MASUDA H. , YAMADA H. , TSURUTA H. , MATSUKAWA S. , YAMAGUCHI K. 
Published: July 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Optical Resolution by Preferential Crystallization of (RS)‐Bromosuccinic Acid
Authors: SHIRAIWA T. , OHKUBO M. , MIYAZAKI H. , KUBO M. , NISHIGAWA H. , TSUJIMOTO T. , KUROKAWA H. 
Published: July 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Control of Both syn and anti Stereoselectivity in Michael Additions of Organotin Enolates.
Authors: SHIBATA I. , YASUDA K. , TANAKA Y. , YASUDA M. , BABA A. 
Published: July 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Substituent Effects on Site Selectivity (C=C vs C=N) in Heterocumulene—Heterodiene [4 + 2] Cycloadditions: Density Functional and Semiempirical AM1 Molecular Orbital Calculations.
Authors: FABIAN W. M. F. , KOLLENZ G. 
Published: July 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: A Novel Precursor for Per(poly)fluoroalkyl Heterocycles from N‐Aryl Per(poly)fluoroalkyl Imidoyl Iodides.
Authors: YU H.‐B. , HUANG W.‐Y. 
Published: July 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Palladium‐Catalyzed Cyclization—Intermolecular Cyclopropanation versus Cyclization Friedel—Crafts Alkylation with Olefin Insertion.
Authors: BROWN D. , GRIGG R. , SRIDHARAN V. , TAMBYRAJAH V. , THORNTON‐PETT M. 
Published: July 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis of 5,6,7,8‐Tetrahydro‐2H‐1‐benzopyran‐2,5‐diones and 1,5‐Dihydro‐2H‐pyrrol‐2‐ones.
Authors: MUSIC I. , GOLOBIC A. , VERCEK B. 
Published: July 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Carboxy(vinyl)ketene Intermediates in the Thermolysis of Methylthio‐ and Methoxy‐Substituted Meldrum′s Acid Derivatives (I).
Authors: BIBAS H. , KAPPE C. O. , WONG M. W. , WENTRUP C. 
Published: July 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Perfluorophenylation of Aromatic and Heteroaromatic Compounds with Pentafluorobenzenesulfonyl Chloride Catalyzed by a Ruthenium(II) Phosphine Complex.
Authors: KAMIGATA N. , YOSHIKAWA M. , SHIMIZU T. 
Published: July 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: α‐Silyl Ethers as Hydroxymethyl Anion Equivalents in Photoinduced Radical Electron Transfer Additions.
Authors: GUTENBERG G. , STECKHAN E. , BLECHERT S. 
Published: July 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Addition of Dialkylzinc to Ketones in the Presence of Silylating Agents: Synthesis of Functionalized Tertiary Silyl Ethers.
Authors: ALVISI C. , CASOLARI S. , COSTA A. L. , RITIANI M. , TAGLIAVINI E. 
Published: July 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: A Practical, Stereoselective Synthesis of (E)‐ and (Z)‐2‐Bromo‐2‐pentenes.
Authors: KIM H. , LEE S.‐K. , LEE D. , CHA J. K. 
Published: July 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Stereocontrol in Aldol Addition — Synthesis of syn and anti 3‐Hydroxy Aldehydes.
Authors: MAHRWALD R. , COSTISELLA B. , GUENDOGAN B. 
Published: July 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: The Adduct of BiCl3 and Mo6Cl12: [BiCl] Dumbbells in the Structure of [BiCl][Mo6Cl14].
Authors: BECK J. , HENGSTMANN M. 
Published: July 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: A Fluoride Phosphate of Manganese(III) with Unusual Layer Structure: Na7 [Mn5F13(PO4)3 (H2O)3].
Authors: STIEF R. , FROMMEN C. , PEBLER J. , MASSA W. 
Published: July 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.