bluuebunny/crossref_metadata_2025_split huggingface dataset:
Stb3 Plays a Role in the Glucose-Induced Transition from Quiescence to Growth inSaccharomyces cerevisiae
Authors: Liko Dritan , Conway Michael K , Grunwald Douglas S , Heideman Warren 
Published: April 2010

AbstractAddition of glucose to quiescent Saccharomyces cerevisiae cells causes the immediate induction of ∼1000 genes. These genes include ribosomal proteins (RP) and non-RP genes needed for ribosome production and other growth processes. RRPE sequence elements are commonly found 5′ of non-RP growth gene ORFs, and Stb3 has recently been identified as an RRPE binding protein. Stb3 overexpression (Stb3OE) produces a slow growth phenotype that is associated with reduced expression of non-RP genes and a drop in the rate of amino acid incorporation. Genes affected by Stb3 are associated with a TGAAAAA motif. Stb3 is restricted to the nucleus in quiescent cells and is immediately released into the cytoplasm after glucose repletion. The Stb3OE slow growth phenotype is reversed by loss of Hos2 histone deactylase activity, consistent with the idea that repression involves histone deacetylation. SCH9 overexpression or PPH22 deletion, mutations that activate target of rapamycin (Tor) nutrient sensing pathways, also reverse the Stb3OE phenotype. Inhibition of Tor signaling makes the phenotype more severe and restricts Stb3 to the nucleus. The results support a model in which Stb3 is one of the components that repress a large set of growth genes as nutrients are depleted. This repression is ended by glucose.
Cumulative Hardship and Wellness of Low-Income, Young Children: Multisite Surveillance Study
Authors: Frank Deborah A. , Casey Patrick H. , Black Maureen M. , Rose-Jacobs Ruth , Chilton Mariana , Cutts Diana , March Elizabeth , Heeren Timothy , Coleman Sharon , de Cuba Stephanie Ettinger , Cook John T. 
Published: April 2010

OBJECTIVES:The goals were to generate a cumulative hardship index and to evaluate its association with the well-being of children 4 to 36 months of age without private health insurance.METHODS:Cross-sectional surveys were linked to anthropometric measures and medical record review at 5 urban medical centers (July 1, 2004, to December 31, 2007). Cumulative hardship index scores ranged from 0 to 6, with food, housing, and energy each contributing a possible score of 0 (secure), 1 (moderately insecure), or 2 (severely insecure) to generate scores indicating no hardship (score of 0), moderate hardship (scores of 1–3), or severe hardship (scores of 4–6). The outcome was a composite indicator of child wellness, including caregivers' reports of children's good/excellent heath, no hospitalizations, not being developmentally at risk, and anthropometric measurements within normal limits. Covariates were selected a priori and through association with predictors and outcomes.RESULTS:Of 7141 participants, 37% reported no material hardship, 57% moderate hardship, and 6% severe hardship. Multivariate logistic regression analyses showed ordinal association between the cumulative hardship index and children's adjusted odds of wellness (severe versus no hardship, adjusted odds ratio [AOR]: 0.65 [95% confidence interval [CI]: 0.51–0.83]; severe versus moderate hardship, AOR: 0.73 [95% CI: 0.58–0.92]; moderate versus no hardship, AOR: 0.89 [95% CI: 0.79–0.99]).CONCLUSION:Increasing levels of a composite measure of remediable adverse material conditions correlated with decreasing adjusted odds of wellness among young US children.
Teaching Pediatric Residents to Assess Adolescent Suicide Risk With a Standardized Patient Module
Authors: Fallucco Elise M. , Hanson Mark D. , Glowinski Anne L. 
Published: April 2010

OBJECTIVE:
We hypothesized that a suicide risk assessment (SRA) training module incorporating standardized patients (SPs) would enhance pediatric resident SRA performance.

METHODS:
We conducted an educational survey of pediatric residents regarding SRA (N = 80). In addition, we tested the performance of a SRA training module among pediatric interns who received SRA practice with SPs simulating suicidality scenarios, with (n = 6) or without (n = 6) SRA lecture, or SRA lecture only (n = 12) and control interns (n = 10). We examined postintervention confidence in SRA and self-reported and objectively measured knowledge of suicidal risk factors.

RESULTS:
Resident confidence and knowledge regarding SRA were low, compared with assessment of medical illness. Interns in the SP plus lecture group had significantly greater confidence in screening adolescents for suicide risk factors and assessing suicidal adolescents (screening, 4.2 ± 0.4; assessing, 4.2 ± 0.4), compared with subjects in either the lecture-only (screening, 2.9 ± 0.8; P = .005; assessing, 2.9 ± 1.1; P = .01) or control (screening, 3.1 ± 0.7; P = .025; assessing, 2.6 ± 0.8; P = .003) group. In addition, only the SP plus lecture group demonstrated significantly greater objective knowledge of suicide risk factors (92% vs 25% correct; P = .008) than the control group. Neither the lecture-only group nor the SP-only group was significantly better than the control group in terms of knowledge or confidence relevant to SRA.

CONCLUSION:
This SRA training module was significantly more effective than lecture alone in enhancing pediatric intern knowledge and confidence in SRA.
Yield of Retinal Examination in Suspected Physical Abuse With Normal Neuroimaging
Authors: Thackeray Jonathan D. , Scribano Philip V. , Lindberg Daniel M. 
Published: April 2010

OBJECTIVE:In some centers, dedicated ophthalmologic examination is performed for all children who are evaluated for potential physical abuse. Although retinal hemorrhages have been reported in rare cases of abused children with normal neuroimaging results, the utility of ophthalmologic examination in this group is currently unknown. The objective of this study was to determine the prevalence of retinal hemorrhages in children younger than 2 years who were evaluated for physical abuse and who had no evidence of traumatic brain injury (TBI) on neuroimaging.PATIENTS AND METHODS:We performed retrospective analysis of data obtained from 1676 children younger than 5 years who were evaluated for potential physical abuse as a part of the Using Liver Transaminases to Recognize Abuse research network. We reviewed results of dedicated ophthalmologic examination in all children younger than 2 years with no evidence of TBI on neuroimaging.RESULTS:Among 282 children who met inclusion criteria, only 2 (0.7% [95% confidence interval: 0.1%–2.5%]) had retinal hemorrhages considered “characteristic” of abuse. Seven other children (2.5% [95% confidence interval: 1.0%–5.1%]) had a nonspecific pattern of retinal hemorrhages. Both children with characteristic retinal hemorrhages in the absence of TBI showed evidence of head or facial injury on physical examination and/or altered mental status.CONCLUSIONS:In children younger than 2 years being evaluated for physical abuse without radiographic evidence of brain injury, retinal hemorrhages are rare. Dedicated ophthalmologic examination should not be considered mandatory in this population.
Human Recombinant Erythropoietin in Asphyxia Neonatorum: Pilot Trial
Authors: Elmahdy Heba , El-Mashad Abdel-Rahman , El-Bahrawy Hoda , El-Gohary Tareq , El-Barbary Ali , Aly Hany 
Published: April 2010

OBJECTIVE:The goal was to examine biochemical, neurophysiologic, anatomic, and clinical changes associated with erythropoietin administration to neonates with hypoxic-ischemic encephalopathy (HIE).METHODS:We conducted a prospective case-control study with 45 neonates in 3 groups, a normal healthy group (N = 15), a HIE-erythropoietin group (N = 15; infants with mild/moderate HIE who received human recombinant erythropoietin, 2500 IU/kg, subcutaneously, daily for 5 days), and a HIE-control group (N = 15; did not receive erythropoietin). Serum concentrations of nitric oxide (NO) were measured at enrollment for the normal healthy neonates and at enrollment and after 2 weeks for the 2 HIE groups. The 2 HIE groups underwent electroencephalography at enrollment and at 2 to 3 weeks. Brain MRI was performed at 3 weeks. Neurologic evaluations and Denver Developmental Screening Test II assessments were performed at 6 months.RESULTS:Compared with normal healthy neonates, the 2 HIE groups had greater blood NO concentrations (P &lt; .001). At enrollment, the 2 HIE groups did not differ in clinical severity, seizure incidence, NO concentrations, or electroencephalographic findings. At 2 weeks of age, electroencephalographic backgrounds improved significantly (P = .01) and NO concentrations decreased (P &lt; .001) in the HIE-erythropoietin group, compared with the HIE-control group; MRI findings did not differ between groups. At 6 months of age, infants in the HIE-erythropoietin group had fewer neurologic (P = .03) and developmental (P = .03) abnormalities.CONCLUSION:This study demonstrates the feasibility of early administration of human recombinant erythropoietin to term neonates with HIE, to protect against encephalopathy.
Standardized Screening for Suicidal Adolescents in Primary Care
Authors: Wintersteen Matthew B. 
Published: April 2010

OBJECTIVE:
To determine if brief standardized screening for suicide risk in pediatric primary care practices will increase detection rates of suicidal youth, maintain increased detection and referral rates, and be replicated in other practices.

PATIENTS AND METHODS:
Physicians in 3 primary care practices received brief training in suicide risk, and 2 standardized questions were inserted into their existing electronic medical chart psychosocial interview. The questions automatically populated for all adolescents aged 12.0 to 17.9 years. Deidentified data were extracted during both intervention trials and for the same dates of the previous year. Referral rates were extracted from social work records.

RESULTS:
The rates of inquiry about suicide risk increased 219% (clinic A odds ratio [OR]: 2.04 [95% confidence interval (CI): 1.56–2.51]; clinic B OR: 3.20 [95% CI: 2.69–3.71]; clinic C OR: 1.85 [95% CI: 1.38–2.31]). The rate of case detection increased in clinic A (OR: 4.99 [95% CI: 4.20–5.79]), was maintained over 6 months after the intervention began (OR: 4.38 [95% CI: 3.74–5.02]), and was replicated in both clinic B (OR: 5.46 [95% [CI: 3.36–7.56]) and clinic C (OR: 3.42 [95% CI: 2.33–4.52]). The increase in case detection was 392% across all 3 clinics. Referral rates of suicidal youth to outpatient behavioral health care centers increased at a rate equal to that of the detection rates.

CONCLUSIONS:
Standardized screening for suicide risk in primary care can detect youth with suicidal ideation and prompt a referral to a behavioral health care center before a fatal or serious suicide attempt is made.
Mother-Daughter Communication and Human Papillomavirus Vaccine Uptake by College Students
Authors: Roberts Megan E. , Gerrard Meg , Reimer Rachel , Gibbons Frederick X. 
Published: April 2010

OBJECTIVES:
Although a human papillomavirus(HPV) vaccine has been available for more than 3 years, little research has documented the uptake and predictors of vaccination among older adolescents and young adult women. The purpose of this cross-sectional study was to examine the prevalence of HPV vaccination among college women across time and to explore the effect of mother-daughter communication on vaccination.

METHODS:
During the period of fall 2007 through fall 2009, a convenience sample of 972 female undergraduate students (aged 18–25) at a large Midwestern state university (89% white) completed a paper-and-pencil or online anonymous questionnaire that assessed their sexual-risk behavior, knowledge of HPV, perceptions of HPV risk, communication from their mothers about sex-related topics (including HPV), and their current vaccination status.

RESULTS:
Sixty-five percent of the women reported being sexually active, and 49% reported having received at least the first of the 3-shot vaccine series. The mother's approval of HPV vaccination, mother-daughter communication about sex, and daughter's perceptions of vulnerability to HPV were positively associated with vaccination status. Among the women who had not received any of the HPV shots, the mother's approval of HPV vaccination, perceived vulnerability to HPV, and risky sexual behavior were predictive of interest in receiving the vaccine. Mother-daughter communication about values related to sex was negatively associated with interest.

CONCLUSIONS:
Although many of these young women were old enough to receive the vaccine without their parents' consent, perception of their mother's approval and mother-daughter communication about sex were important predictors of vaccination.
Stable bundles on hypercomplex surfaces
Authors: Moraru Ruxandra , Verbitsky Misha 
Published: April 2010

Abstract
A hypercomplex manifold is a manifold equipped with three complex structures I, J, K satisfying the quaternionic relations. Let M be a 4-dimensional compact smooth manifold equipped with a hypercomplex structure, and E be a vector bundle on M. We show that the moduli space of anti-self-dual connections on E is also hypercomplex, and admits a strong HKT metric. We also study manifolds with (4,4)-supersymmetry, that is, Riemannian manifolds equipped with a pair of strong HKT-structures that have opposite torsion. In the language of Hitchin’s and Gualtieri’s generalized complex geometry, (4,4)-manifolds are called “generalized hyperkähler manifolds”. We show that the moduli space of anti-self-dual connections on M is a (4,4)-manifold if M is equipped with a (4,4)-structure.
From factorizations of noncommutative polynomials to combinatorial topology
Authors: Retakh Vladimir 
Published: April 2010

Abstract
This is an extended version of a talk given by the author at the conference “Algebra and Topology in Interaction” on the occasion of the 70th Anniversary of D.B. Fuchs at UC Davis in September 2009. It is a brief survey of an area originated around 1995 by I. Gelfand and the speaker.
Multivalued fractals in b-metric spaces
Authors: Boriceanu Monica , Bota Marius , Petruşel Adrian 
Published: April 2010

Abstract
Fractals and multivalued fractals play an important role in biology, quantum mechanics, computer graphics, dynamical systems, astronomy and astrophysics, geophysics, etc. Especially, there are important consequences of the iterated function (or multifunction) systems theory in several topics of applied sciences. It is known that examples of fractals and multivalued fractals are coming from fixed point theory for single-valued and multivalued operators, via the so-called fractal and multi-fractal operators. On the other hand, the most common setting for the study of fractals and multi-fractals is the case of operators on complete or compact metric spaces. The purpose of this paper is to extend the study of fractal operator theory for multivalued operators on complete b-metric spaces.
Non-self mappings in modular spaces and common fixed point theorems
Authors: Razani Abdolrahman , Rakočević Valdimir , Goodarzi Zahraa 
Published: April 2010

Abstract
The aim of this paper, is to introduce the convex structure (specially, Takahashi convex structure) on modular spaces. Moreover, we are interested in proving some common fixed point theorems for non-self mappings in modular space.
On q-Szász-Durrmeyer operators
Authors: Mahmudov Nazim , Kaffaoğlu Havva 
Published: April 2010

Abstract
In the present paper, we introduce the q-Szász-Durrmeyer operators and justify a local approximation result for continuous functions in terms of moduli of continuity. We also discuss a Voronovskaya type result for the q-Szász-Durrmeyer operators.
Fresh Osteochondral Allografting for Osteochondral Lesions of the Talus
Authors: Görtz Simon , De Young Allison J. , Bugbee William D. 
Published: April 2010

Background: Osteochondral lesions of the talus (OLT) are relatively common sequelae of traumatic injuries involving the talus. We report on clinical outcomes of osteochondral allografting (OCA) of the talus for refractory, symptomatic OLT. Materials and Methods: OCA was performed in 12 ankles in 11 patients with OLT. All involved partial, unipolar grafts of the talar dome, implanted through an anterior approach without osteotomy, under temporary distraction. Clinical evaluation was performed utilizing the Olerud-Molander Ankle Score (OMAS). Subjective outcome measures included patient questionnaires evaluating pain, function, and satisfaction. Eleven patients (seven males, four females) had a mean age of 35.5 (range, 26 to 57) years. One patient had bilateral involvement. Six OLT affected the medial, six the lateral talar dome. Patients had an average of 1.8 previous surgeries (range, 1 to 5). Mean followup was 38 (range, 24 to 107) months. Results: Mean OMAS improved from 28 to 71 points ( p < 0.05). Three had further surgery; overall graft survival rate was 10/12. Of surviving grafts, 30% recorded excellent (OMAS: 100 to 91 points), 20% good (OMAS: 90 to 61 points), 30% fair (OMAS: 60 to 31 points), and 20% poor (OMAS: 30 to 0 points) outcomes. All non-failing patients completed questionnaires; 90% were satisfied, 80% reported reduced pain, and 60% improved function. Conclusion: OCA achieved good to excellent results in five of 12 patients, resulting in significant improvement in function and pain with good patient satisfaction. All but one patient avoided arthrodesis. Partial talus OCA is a reasonable treatment option for appropriately selected patients with unipolar OLT. Level of Evidence: IV, Retrospective Case Series
Comparison of Distal Chevron Osteotomy With and Without Lateral Soft Tissue Release for the Treatment of Hallux Valgus
Authors: Lee Ho-Jin , Chung Jin-Wha , Chu In-Tak , Kim Yoon-Chung 
Published: April 2010

Background: A lateral soft tissue release is often performed with distal chevron osteotomy for the correction of hallux valgus deformities. However, many complications of lateral soft tissue release have been reported. To define the necessity of lateral soft tissue release, the authors compared the clinical and radiographic results of distal chevron osteotomy with and without it. Materials and Methods: 86 consecutive patients (152 feet) were enrolled in this prospective study. In Group A, 45 patients (74 feet) underwent a chevron osteotomy with lateral soft tissue release. In Group B, 41 patients (78 feet) underwent a chevron osteotomy without it. Mean followup was 1.7 years and 2.1 years, respectively. The hallux valgus angle (HVA) and intermetatarsal angle (IMA), and AOFAS score were measured preoperatively, and 1-year followup postoperatively and complications were evaluated. Results: The change in HVA, IMA and AOFAS score were insignificant ( p > 0.05) between Group A and Group B, however, the range of motion of the first metatarsophalangeal joint was significantly less in Group A ( p < 0.05). Complications of digital neuritis and cosmetically dissatisfied scarring of the dorsal web space were seen only in Group A. No cases had avascular necrosis of the metatarsal head, malunion or nonunion. Conclusions: Lateral soft tissue release may not be needed for mild or moderate hallux valgus deformities which may prevent decreased range of motion of the first metatarsophalangeal joint, neuritis of dorsal or plantar lateral digital nerve and cosmetic dissatisfaction of a dorsal scar. Level of Evidence: II, Prospective Comparative Study
Comparative Functional Analysis of Two Different Achilles Tendon Surgical Repairs
Authors: Quagliarella Livio , Sasanelli Nicola , Notarnicola Angela , Belgiovine Giuseppe , Moretti Lorenzo , Moretti Biagio 
Published: April 2010

Background: A number of different surgical procedures have been developed to treat Achilles tendon injuries including open and mini-invasive type. The aim of the present work was to compare the functional outcome of two different techniques, applying a clinical and instrumented protocol. Materials and Methods: Fifty-one subjects were enrolled in the study. The experimental group consisted of 34 patients with a ruptured Achilles tendon, 19 operated by open surgical reconstruction without reinforcement (Open Group), while 15 underwent a mini-invasive procedure (Mini-invasive Group); the Control Group consisted of 17 healthy subjects. The assessment was based on the standing vertical jump, in both countermovement jump and squat jump mode, studying the relative flight times and the coordination of movement of each limb. An accelerometer was fastened to each ankle to obtain an independent assessment of the movement of each limb. Results: The surgically treated patients showed a comparable functional performance to that of the Control Group but despite this full recovery they showed a tendency to “favor” the affected limb. This finding was more marked in the Mini-invasive Group. The Control Group invariably showed better coordination of the movement of the two limbs than the two experimental groups. This was particularly apparent in the take-off phase, indicated by asymmetrical push-off of the two limbs. Conclusion: The jumping evaluation used in this study resulted in similar results between the open and the mini-invasive techniques. Level of Evidence: III, Retrospective Comparative Study
Minimally Invasive Distraction Technique for Prone Posterior Ankle and Subtalar Arthroscopy
Authors: Beals Timothy C. , Junko Jeffrey T. , Amendola Annunziato , Nickisch Florian , Saltzman Charles L. 
Published: April 2010

Background: Prone ankle and subtalar arthroscopy is challenging in part due to the limited working space in these joints. Materials and Methods: Fourteen patients undergoing prone posterior arthroscopy with a novel skeletal traction method were reviewed and the technique detailed. Results: No complications were observed in 14 patients treated with a minimally invasive skeletal traction technique for prone ankle and subtalar arthroscopy and 38 patients treated with the same traction device during supine ankle arthroscopy. Conclusion: Minimally invasive skeletal traction can be used safely for prone posterior ankle and subtalar arthroscopy. Level of Evidence: IV, Retrospective Case Series
Identification of Peanut Stripe Virus Resistance in Wild Arachis Germplasm1,,2
Authors: Rao R. D. V. J. Prasada , Reddy A. S. , Chakrabarty S. K. , Reddy D. V. R. , Rao V. R. , Moss J. P. 
Published: April 2010

Abstract
Fifty four wild Arachis germplasm accessions were evaluated for resistance to peanut stripe virus (PStV) by mechanical, aphid, and graft inoculations. Three weeks after inoculation, inoculated and subsequently produced leaflets of each entry were tested for PStV presence by enzyme-linked immunosorbent assay (ELISA). Peanut accessions in the section Arachis, A. cardenasii [ICG 11558 (PI 475998)] could not be infected by mechanical, aphid, and graft transmission tests, while A. chacoense [ICG 4983 (PI 276235)], A. cardenasii [ICG 11562 (PI 476012) and ICG 12168 (PI 476013)] and accessions of section Erectoides, A. sp. [ICG 11560 (PI 476004) and ICG 8215 (PI 468170)] and A. paraguariensis [ICG 8973 (PI 468176)], were infected by grafting, but not by aphid and mechanical inoculations.