bluuebunny/crossref_metadata_2025_split huggingface dataset:
A virtual histology intravascular ultrasound analysis of coronary chronic total occlusions
Authors: Guo Jun , Maehara Akiko , Mintz Gary S , Ashida Kazuhiro , Pu Jun , Shang Yunpeng , Leon Martin B. , Stone Gregg W. , Moses Jeffrey W. , Ochiai Masahiko 
Published: March 2012

ObjectivesWe used virtual histology intravascular ultrasound (VH‐IVUS) to investigate plaque composition of chronic total occlusions (CTO).BackgroundThere are limited data on the composition of CTOs, especially in vivo.MethodsVH‐IVUS was performed in 50 CTO lesions (49 patients) after guidewire crossing or pre‐dilation using a 1.5–2 mm balloon. Plaque composition in the proximal reference, distal reference, and CTO segment (subsequently divided into proximal, middle, and distal subsegments) was analyzed and reported as median and interquartile range. VH‐IVUS phenotype was also assessed. The definition of a fibroatheroma was >10% confluent necrotic core (NC) in more than three consecutive frames.ResultsOverall, the maximum NC within the CTO [35.5% (28.7, 44.3%)] was similar to the proximal reference [35.6% (24.1, 42.1%)] and greater than the distal reference [31.5% (22.6, 35.2%), P < 0.01]. There was no difference in maximum NC observed among proximal [31.4% (25.2, 10.4%)], middle [31.0% (23.3, 38.3%)], and distal CTO subsegments [30.4% (22.0, 39.5%)]. Overall, 42/50 CTOs contained a VH‐fibroathroma; and 8/50 did not. CTOs containing a VH‐fibroatheroma had more NC and dense calcium while CTOs not containing a fibroatheroma had more fibrotic and fibrofatty plaque. Importantly, 60.5% of VH‐fibroatheroma‐containing CTOs had a thin‐cap fibroatheroma (NC abutted to the lumen) in the proximal reference.ConclusionsUsing VH‐IVUS, CTO morphology can be divided into two patterns: (1) CTO with VH‐fibroatheroma or (2) CTO without VH‐fibroatheroma. This suggests two mechanisms of CTO formation—the majority evolving from acute coronary syndrome and thrombosis and the minority from atherosclerosis progression. © 2012 Wiley Periodicals, Inc.
Quantification of temporal, procedural, and hardware‐related factors influencing radiation exposure during pediatric cardiac catheterization
Authors: Smith Benjamin G. , Tibby Shane M. , Qureshi Shakeel A. , Rosenthal Eric , Krasemann Thomas 
Published: March 2012

AbstractPurposeTo quantify the impact of relocation to a purpose built pediatric cardiac catheterization laboratory, on patient radiation dose and fluoroscopy time. To provide guide values for radiation exposure during common structural interventions.Material and methodsDesign: A retrospective review of common structural cardiac interventions performed over 10‐years. The era comprised two 5‐year periods before and after relocation using different catheter laboratories. Multivariable analysis adjusted for the following variables: era (pre‐ and post‐move), year, operator seniority, patient age, procedure type. Setting: A quaternary referral congenital cardiac centre. Patients: All patients <18 yrs (n = 756) in whom one of 6 common structural interventions were undertaken between 2000 and 2009. Main outcome measures: Radiation dose and fluoroscopy time.ResultsThe move to the new laboratory (latter era) was associated with a dramatic reduction in multivariable‐adjusted radiation dose, ranging from 64% (aortic coarctation stenting) to 87% (patent arterial duct closure). There was also a year upon year increase in radiation dose of 5.2% [95% confidence interval (CI): 0.6–10.0%], which persisted after the relocation. However, this was associated with a 5.1% yearly decrease in fluoroscopy time (95% CI: −7.9 to −2.2%).ConclusionUse of state‐of‐the‐art catheter equipment is associated with a dramatic reduction in radiation exposure. However, the surprising finding of year upon year increase in exposure (despite the new equipment) combined with decreased fluoroscopy time suggests a temporal decrease in hardware efficiency. This has major implications for hardware replacement. © 2012 Wiley Periodicals, Inc.
Late contained aortic root rupture and ventricular septal defect after transcatheter aortic valve implantation
Authors: Aminian Adel , Lalmand Jacques , Dolatabadi Dariouch 
Published: March 2012

AbstractTranscatheter aortic valve implantation (TAVI) is a highly specialized technique offering a new therapeutic option to patients at high risk for conventional surgery. However, despite continuous improvements in operators' expertise and device technology, complications associated with this catheter procedure are not uncommon. We report an unusual case of late contained rupture of the aortic annulus, combining a para‐aortic false aneurysm and a ventricular septal defect, after the placement of an Edwards Sapien prosthesis. © 2012 Wiley Periodicals, Inc.
Occlusion of the perimembranous ventricular septal defect using CERA® devices
Authors: Esteves Cesar A. , Solarewicz Leo A. , Cassar Renata , Neves Juliana R. , Esteves Vinicius , Arrieta Raul 
Published: March 2012

AbstractBackgroundHigh incidence of atrioventricular (AV) block has been the major limitation of percutaneous closure of perimembranous ventricular septal defect (PMVSD).MethodsProspective, multicenter, nonrandomized study including 55 patients who were submitted to 56 procedures from March 2010 to November 2010. Inclusion criteria were PMVSD with diameter ≥ 5 mm or if ≤5 mm with hemodynamic significance and age ≥ 1 year. Exclusion criteria were fixed pulmonary arterial hypertension and associated congenital heart disease needing surgical repair. Procedures were performed under general anesthesia and monitored by transthoracic echocardiography (TTE). The device choice was based on left ventricle (LV) angiography and on TTE images. PMVSDs were crossed by retrograde approach.ResultsMean age was 9.3 ± 7.5 years, and mean weight was 29.1 ± 15.9 kg. Thirty‐five (63.6%) patients were females. Mean pulmonary arterial mean pressure, mean LV diastolic diameter, and mean Qp/Qs were 24.0 ± 6.5 mm Hg, 43.0 ± 5.9 mm, and 2.2 ± 0.8, respectively. Associated nonsurgical malformations were present in 9 (16.3%) patients, and PMVSDs were multifenestrated in 16 (46.2%) cases. Mean PMVSDs diameter was 5.8 ± 1.8 mm by angiography and 6.8 ± 2.3 mm by TTE. New rhythm disturbance without clinical significance was observed in 29% of the patients and was reversible in 87.5%. After procedure, trivial residual shunt was present in 5 (8.9%) patients and moderate residual shunt in other 5 (8.9%). At late FU (mean of 298.7 ± 88.9 days), 91% of the patients had no residual shunts. Third‐degree AV block and severe aortic regurgitation occurred in one patient each.ConclusionsIn this experience, PMVSD closure with CERA® devices showed to be safe and effective with low incidence of complications at immediate and mid‐term FU. © 2012 Wiley Periodicals, Inc.
Severe aortic valve regurgitation after percutaneous ventricular septal defect closure
Authors: Fouilloux Virginie , Kreitmann Bernard 
Published: March 2012

AbstractPercutaneous closure of ventricular septal defect is now commonly used. We report a rare case, and especially a rare image of aortic leaflet damage caused by percutaneous ventricular septal device. © 2012 Wiley Periodicals, Inc.
Active Site Transformation During the Induction Period of Ethylene Polymerization over the Phillips CrOx/SiO2 Catalyst
Authors: Zhong Lei , Liu Zhen , Cheng Ruihua , Tang Siyang , Qiu Pengyuan , He Xuelian , Terano Minoru , Liu Boping 
Published: March 2012

AbstractIn spite of the great importance of the Phillips catalyst in commercial polyethylene production and long‐term research efforts, the initiation mechanism of polymerization still remains unclear. The effect of formaldehyde desorption on the active site transformation during the induction period of the Phillips catalyst is investigated over cluster models by using DFT. No reaction can be initiated over the cluster model coordinated with two formaldehyde molecules, owing to steric hindrance and electronic donation. The first reaction over cluster models, on which either one or no formaldehyde molecule is adsorbed, follows the metallacyclic mechanism into chromacyclopentane. Subsequent dimerization to 1‐butene and metathesis to propylene and ethylene are more favorable over the cluster model adsorbed with one formaldehyde molecule. Only after a complete desorption of formaldehyde does further ring expansion to chromacycloheptane followed by 1‐hexene formation become preferential. Spin state crossing from quintet diethylene–CrII complex to triplet chromacyclopentane with a spin acceleration effect is revealed.
Design and Synthesis of Fluorescent Pilicides and Curlicides: Bioactive Tools to Study Bacterial Virulence Mechanisms
Authors: Chorell– Erik , Pinkner Jerome S. , Bengtsson Christoffer , Edvinsson Sofie , Cusumano Corinne K. , Rosenbaum Erik , Johansson Lennart B. Å. , Hultgren Scott J. , Almqvist Fredrik 
Published: March 2012

AbstractPilicides and curlicides are compounds that block the formation of the virulence factors pili and curli, respectively. To facilitate studies of the interaction between these compounds and the pili and curli assembly systems, fluorescent pilicides and curlicides have been synthesized. This was achieved by using a strategy based on structure–activity knowledge, in which key pilicide and curlicide substituents on the ring‐fused dihydrothiazolo 2‐pyridone central fragment were replaced by fluorophores. Several of the resulting fluorescent compounds had improved activities as measured in pili‐ and curli‐dependent biofilm assays. We created fluorescent pilicides and curlicides by introducing coumarin and 4,4‐difluoro‐4‐bora‐3a,4a‐diaza‐s‐indacene (BODIPY) fluorophores at two positions on the peptidomimetic pilicide and curlicide central fragment. Fluorescence images of the uropathogenic Escherichia coli (UPEC) strain UTI89 grown in the presence of these compounds shows that the compounds are strongly associated with the bacteria with a heterogeneous distribution.
Innovative triboluminescence study of multivitamin doped europium tetrakis
Authors: Fontenot R. S. , Bhat K. N. , Hollerman W. A. , Aggarwal M. D. 
Published: March 2012

AbstractAs the Space Shuttle program ends, NASA is developing the next generation of space vehicles. These new concept designs will require new and innovative structural health monitoring capabilities. One way to solve this problem is with smart impact sensors that use triboluminescent materials. In 2011, the authors reported an 82% increase in the triboluminescence yield of europium dibenzoylmethide triethylammonium (EuD4TEA) by changing the starting material. It has been shown that introduction of dopants tends to enhance the triboluminescent light yield. Here we report the successful synthesis of a multivitamin doped europium tetrakis which appears to be spherical in shape. Inductively Coupled Plasma – Optical Emission Spectroscopy analysis showed the presence of 3.6% calcium, 0.62% magnesium, 0.1% iron, 0.01% copper and manganese. This new product has no shift in the triboluminescent or photoluminescent emission peaks, but only a change in the intensity. In addition, the doped EuD4TEA powder statistically emits more triboluminescence while having the same decay time. (© 2012 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Preparation and characterisation of Ag incorporated Al2O3 nanocomposite films obtained by sol‐gel method
Authors: Ivanova T. , Harizanova A. , Koutzarova T. , Vertruyen B. 
Published: March 2012

AbstractSol‐gel route has been applied for a deposition of the thin films of aluminum oxide and Ag embedded in Al2O3 films. The films are spin‐coated on Si and quartz substrates with the film thickness of 120 nm. XRD analysis has been used for the determination of the film structure. FTIR spectroscopy is applied for studying vibrational properties of the obtained coatings. Optical characterization is done by UV‐VIS spectroscopy. The formation of Ag nanoparticles has been confirmed by XRD and optical data. The sol‐gel process is found to be useful technology for incorporation of Ag nanoparticles in the metal oxide matrices. (© 2012 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Gas‐Pulsed CVD for Film Growth in the CuNiN System
Authors: Lindahl Erik , Ottosson Mikael , Carlsson Jan‐Otto 
Published: March 2012

AbstractA new ternary solid solution, Cu3‐xNix+yN, is prepared by gas‐pulsed CVD at 260 °C. Gas pulses of the precursor mixtures Cu(hfac)2 + NH3 and Ni(thd)2 + NH3, separated by intermittent ammonia pulses, are employed for the deposition of Cu3N and Ni3N, respectively. A few monolayers of the nitrides are grown in each CVD pulse and then mixed by diffusion to produce the solid solution. The metal content of the solid solution can be varied continuously from 100% to about 20% Cu, which means that the electrical properties can be varied from 1.6 eV (band gap of Cu3N) to metallic (Ni3N). This is of interest for various applications, e.g., solar energy, catalysis, and microelectronics.
Fhos encodes a Drosophila Formin‐Like Protein participating in autophagic programmed cell death
Authors: Anhezini Lucas , Saita Ana Paula , Costa Mara S.A. , Ramos Ricardo Guelerman Pinheiro , Simon Claudio Roberto 
Published: March 2012

AbstractLarval tissues undergo programmed cell death (PCD) during Drosophila metamorphosis. PCD is triggered in a stage and tissue‐specific fashion in response to ecdysone pulses. The understanding of how ecdysone induces the stage and tissue‐specificity of cell death remains obscure. Several steroid‐regulated primary response genes have been shown to act as key regulators of cellular responses to ecdysone by inducing a cascade of transcriptional regulation of late responsive genes. In this article, the authors identify Fhos as a gene that is required for Drosophila larval salivary gland destruction. Animals with a P‐element mutation in Fhos possess persistent larval salivary glands, and precise excisions of this P‐element insertion resulted in reversion of this salivary gland mutant phenotype. Fhos encodes the Drosophila homolog of mammalian Formin Fhos. Fhos is differentially transcribed during development and responds to ecdysone in a method that is similar to other cell death genes. Similarly to what has been shown for its mammalian counterpart, FHOS protein is translocated to the nucleus at later stages of cell death. Fhos mutants posses disrupted actin cytoskeleton dynamics in persistent salivary glands. Together, our data indicate that Fhos is a new ecdysone‐regulated gene that is crucial for changes in the actin cytoskeleton during salivary gland elimination in Drosophila. genesis 50:672–684, 2012. © 2012 Wiley Periodicals, Inc.
Heterometallic Complexes of Ruthenium and Lanthanides (Ce, Pr, Nd, Eu) with NO2 Bridges – Synthesis, Structures, Properties
Authors: Borodin A. O. , Kostin G. A. , Plusnin P. E. , Filatov E. Yu. , Bogomyakov A. S. , Kuratieva N. V. 
Published: March 2012

AbstractFive new heterometallic complexes with a {Ln[RuNO(μ‐NO2)4(μ3‐OH)]2Ln} (Ln = Ce, Pr, Nd, Eu) core were prepared by reaction of Na2[RuNO(NO2)4OH] and lanthanide nitrates in the presence of pyridine. The crystal structures of the obtained compounds were determined by single‐crystal X‐ray analysis. In all complexes, Ru and Ln atoms are connected by N,O‐bridging nitrite groups and OH groups. The coordination environment of Ln3+ is completed by oxygen atoms of nitrate ions and water molecules and by nitrogen atoms of pyridine molecules. Magnetic interactions between lanthanide atoms become apparent at temperatures lower than 40–50 K, and at temperatures higher than 100 K, the dependencies of the magnetic susceptibilities of the complexes are well explained by the presence of two noninteracting paramagnetic centers. Thermal decomposition of the investigated complexes in an inert atmosphere results in a mixture of metallic ruthenium and the corresponding lanthanide oxide. Formation of mixed oxide phases RuPrOx was also detected after decomposition of the praseodymium complex.
(Dis)Connectivity in catchment sediment cascades: a fresh look at the sediment delivery problem
Authors: Fryirs Kirstie 
Published: March 2012

ABSTRACTThe concept of the sediment delivery problem was introduced into the literature in 1983 by Des Walling. This concept describes how only a fraction of sediment eroded within a catchment will reach the basin outlet and be represented as sediment yield, and that sediment storage mechanisms operating within a catchment explain this discrepancy. Since this paper was published, geomorphologists have been examining in great detail the fate of sediment eroded from the landsurface, and the pathways and timeframes of sediment transport and storage in catchments. However, to fully understand the internal dynamics of sediment flux requires a ‘fresh look at the sediment delivery problem’. A framework is required that can incorporate the various processes involved in sediment movement from source areas through a basin to its outlet, and can take account of the spatial distribution of, and timeframes over which, these processes operate.This paper presents a conceptual framework for analysis of catchment (dis)connectivity that incorporates both spatial and temporal variability in the operation of the sediment cascade. This approach examines where blockages occur to disrupt these longitudinal, lateral and vertical linkages in catchments. Depending on the position of blockages (termed buffers, barriers and blankets), and their sediment residence time, various parts of a catchment may be actively contributing sediment to the sediment cascade and be switched on, or inactive and switched off. This paper discusses how such a framework can be used to model response times to disturbance and explain the manifestation of geomorphic change in catchments. The paper then highlights challenges geomorphologists face in applying such a framework to understand the internal dynamics of the catchment sediment cascades, and forecast how environmental change might affect the operation of sediment fluxes into the future. Copyright © 2012 John Wiley & Sons, Ltd.
Functional parcellation of the inferior frontal and midcingulate cortices in a flanker‐stop‐change paradigm
Authors: Enriquez‐Geppert Stefanie , Eichele Tom , Specht Karsten , Kugel Harald , Pantev Christo , Huster René J. 
Published: March 2012

AbstractConflict monitoring and motor inhibition are engaged in the performance of complex tasks. The midcingulate cortex (MCC) has been suggested to detect conflicts, whereas the right inferior frontal cortex (IFC) seems to be of relevance for the inhibition process. The current experiment investigates the neural underpinnings of their interplay via a modified flanker paradigm. Conflict was manipulated by the congruency of flanking stimuli relative to a target (congruent vs. incongruent) and motor inhibition by a within‐trial response change of the initiated response (keep response vs. stop‐change). We used event‐related functional magnetic resonance imaging, decomposition with high model order ICA, and single trial analysis to derive a functional parcellation of the whole‐brain data. Results demonstrate the segmentation of the MCC into anterior and posterior subregions, and of the IFC into the pars opercularis, pars triangularis, and pars orbitalis. The pars opercularis and pars triangularis of the right IFC constituted the foundation of inhibition‐related networks. With high conflict on incongruent trials, activity in the posterior MCC network, as well as in one right IFC network was observed. Stop‐change trials modulated both the MCC as well as networks covering extended parts of the IFC. Whereas conflict processing and inhibition most often are studied separately, this study provides a synopsis of functionally coupled brain regions acting in concert to enable an optimal performance in situations involving interference and inhibition. Hum Brain Mapp, 2013. © 2012 Wiley Periodicals, Inc.
A magnetoencephalographic study of face processing: M170, gamma‐band oscillations and source localization
Authors: Gao Zaifeng , Goldstein Abraham , Harpaz Yuval , Hansel Myriam , Zion‐Golumbic Elana , Bentin Shlomo 
Published: March 2012

AbstractEEG studies suggested that the N170 ERP and Gamma‐band responses to faces reflect early and later stages of a multiple‐level face‐perception mechanism, respectively. However, these conclusions should be considered cautiously because EEG‐recorded Gamma may be contaminated by noncephalic activity such as microsaccades. Moreover, EEG studies of Gamma cannot easily reveal its intracranial sources. Here we recorded MEG rather than EEG, assessed the sources of the M170 and Gamma oscillations using beamformer, and explored the sensitivity of these neural manifestations to global, featural and configural information in faces. The M170 was larger in response to faces and face components than in response to watches. Scrambling the configuration of the inner components of the face even if presented without the face contour reduced and delayed the M170. The amplitude of MEG Gamma oscillations (30–70 Hz) was higher than baseline during an epoch between 230–570 ms from stimulus onset and was particularly sensitive to the configuration of the stimuli, regardless of their category. However, in the lower part of this frequency range (30–40 Hz) only physiognomic stimuli elevated the MEG above baseline. Both the M170 and Gamma were generated in a posterior‐ventral network including the fusiform, inferior‐occipital and lingual gyri, all in the right hemisphere. The generation of Gamma involved additional sources in the visual system, bilaterally. We suggest that the evoked M170 manifests a face‐perception mechanism based on the global characteristics of face, whereas the induced Gamma oscillations are associated with the integration of visual input into a pre‐existent coherent perceptual representation. Hum Brain Mapp, 2013. © 2012 Wiley Periodicals, Inc.
Head and neck squamous cell carcinoma in pregnant women
Authors: Eliassen Anna M. , Hauff Samantha J. , Tang Alice L. , Thomas Dafydd H. , McHugh Jonathan B. , Walline Heather M. , Stoerker Jay , Maxwell Jessica H. , Worden Francis P. , Eisbruch Avraham , Czerwinski Michael J. , Papagerakis Silvana M. , Chepeha Douglas B. , Bradford Carol R. , Hanauer David A. , Carey Thomas E. , Prince Mark E. 
Published: March 2012

AbstractBackgroundThe aim of this study was to investigate oral cancer in pregnant women, a rare but therapeutically challenging patient subset.MethodsAfter institutional review board approval, an EMERSE search was used to identify all women treated at the University of Michigan from 1998 to 2010 with head and neck squamous cell carcinoma (HNSCC) during pregnancy. This identified 4 patients with tongue cancer. Biomarkers and human papillomavirus (HPV) were assessed by immunohistochemistry and multiplex PCR/mass spectrometry, respectively.ResultsTwo patients responded well to therapy and are alive more than 10 years after diagnosis; 2 patients died of disease. All tumors overexpressed EGFR and Bcl‐xL, 3 of 4 overexpressed c‐Met, both tumors that progressed overexpressed p53. All tumors were negative for HPV, p16, estrogen receptor, progesterone receptor, and HER‐2.ConclusionsBiomarkers of aggressive tumors (high EGFR, c‐Met; high Bcl‐xL‐low p53) did not correlate with outcome. Additional studies are needed to determine whether perineural invasion, delay in diagnosis, and p53 overexpression are factors in poor survival. © 2012 Wiley Periodicals, Inc. Head Neck, 2013