bluuebunny/crossref_metadata_2025_split huggingface dataset:
Relative growth, life-history phases, and sexual maturity of American lobster (Homarus americanus)
Authors: Émond Kim , Sainte-Marie Bernard , Gendron Louise 
Published: May 2010

Previous studies of relative growth in crustaceans have focused primarily on body parts representing sexual characters for the purpose of determining size at onset of sexual maturity. We have revisited the relative growth of abdomen and crusher claw in American lobster ( Homarus americanus H. Milne Edwards, 1837) in a general life-history perspective using a broad spectrum of lobster sizes (6–160 mm cephalothorax length (CL)). Growth phases were recognized by inflections in scatterplots of a body-part measurement against CL. The abdomen is characterized by three growth phases in the male and female, whereas the crusher claw has at least three growth phases in the male and at least two in the female. Additionally, we explored relative growth of gonopod and vas deferens for males of 35–150 mm CL. Both organs exhibit a synchronous change from strong to weak positive growth allometry. The growth phases can be associated with major life-history events including the transition from a cryptic to an overt lifestyle and the onset of physiological, functional, and morphometric maturity. The onset of morphometric maturation inferred from relative growth of abdomen and crusher claw precedes functional maturity in females and follows it in males.
Mitochondrial DNA genetic structure transcends natural boundaries in Great Lakes populations of woodland deer mice (Peromyscus maniculatus gracilis)
Authors: Taylor Zachary S. , Hoffman Susan M.G. 
Published: May 2010

The landscape of the Great Lakes region has been fragmented since the lakes formed starting about 20 000 years ago. Small mammals, such as deer mice ( Peromyscus maniculatus (Wagner, 1845)), inhabiting the region therefore face barriers to migration and gene flow, which could complicate ongoing range shifts related to climate change. We analyzed DNA sequences for 481 base pairs of the mitochondrial D-loop to compare mouse genetic structure with the fragmented landscape and geological history of the region. Phylogenetic analyses reveal two distinct lineages of mice in the Great Lakes region. The spatial distribution of these two groups is not congruent with the fragmentation of the landscape; rather, a western group is found from Minnesota through the western Upper Peninsula of Michigan, whereas an eastern group spans southern Ontario and the rest of northern Michigan. The genetic data suggest that the eastern clade colonized Michigan through Ontario from a source shared with southern Appalachian mice, but are less informative for the western clade. Together, these findings suggest that the Great Lakes are relatively porous barriers in the long term but may still have implications for the response of small-mammal communities to climate change.
Ontogeny of swimming movements in bronze corydoras (Corydoras aeneus)
Authors: Mauguit Q. , Olivier D. , Vandewalle N. , Vandewalle P. 
Published: May 2010

Fish larvae experience fundamental morphological, physiological, and physical changes from hatching to adulthood. All of these changes have an effect on the locomotor movements observed in the larvae. We describe the development of swimming movements in larval bronze corydoras ( Corydoras aeneus (Gill, 1858); Ostariophysi, Siluriformes) during their ontogeny. Swimming movements of adults and larvae, aged 0–512 h posthatching, were recorded at 500 frames/s. Movements were analyzed by digitizing points along the fish midline. Movements are described by direct (swimming speed and amplitude of landmarks) and indirect (r2meanand CV of r2as movement coordination indices; Strouhal number as an efficiency index) parameters. The increase in swimming speed correlated with improvement of movement coordination in both larvae and adults, as well as with an increase in swimming efficiency in larvae. Directly after hatching, swimming movements were coordinated but were not efficient. Efficiency increased rapidly with fish growth up to 8 mm total fish length and disappearance of the yolk sac. These events were coupled with reduction of the maximal lateral amplitude observed along the whole body during swimming. The anguilliform swimming mode was used at hatching, but a transition to the carangiform mode was observed at approximately 17 mm total fish length.
Population subdivision of house mice (Mus musculus) in an agrarian landscape: consequences for control
Authors: León V. A. , Fraschina J. , Busch M. 
Published: May 2010

In Argentinean agroecosystems, house mice ( Mus musculus L., 1758) show a discontinuous distribution, with high abundances in farms but scarce abundance in crop fields. In our study area, the abundance of M. musculus could be affected by their movements among farms. We hypothesize that (1) M. musculus do not move among farms versus (2) M. musculus do move among farms. Furthermore, based on our second hypothesis, M. musculus move actively (hypothesis 2.1) or passively by human transport (hypothesis 2.2). Based on hypothesis 1, we predict that genetic subdivision will exist among farms and that genetic divergence will be independent of geographic distance. Based on hypothesis 2.1, genetic differentiation will be correlated with geographic distance. Based on hypothesis 2.2, genetic subdivision will be absent, or genetic differentiation will be related to human movements. We examined genetic variation among farms (n = 15) using five microsatellite loci and tracked the movements of 36 individuals from five farms with fluorescent powders. Populations of M. musculus showed genetic differentiation at both farm and shed scales. Genetic and geographic distances were significantly correlated. There was no evidence of passive movements of M. musculus. The movements of 36 M. musculus within farms, tracked with fluorescent powder, were short. According to these results, hypothesis 2.1 is favoured.
Is there a role for stripes of adults and colour of larvae in determining the avoidance of the Colorado potato beetle by the American toad?
Authors: Boiteau G. , McCarthy P. C. 
Published: May 2010

It has been suggested that the stripes on the elytra of the adult Colorado potato beetle ( Leptinotarsa decemlineata (Say, 1824); Coleoptera: Chrysomelidae) and the red colouration of the larvae are aposematic characters warning predators of their distastefulness as prey. The role of stripes and red colour in determining the avoidance behaviour of the American Toad ( Bufo americanus Holbrook, 1836 = Anaxyrus americanus (Holbrook, 1836); Anura: Bufonidae) for the Colorado potato beetle was investigated in a series of laboratory tests. The behaviour of toads exposed to wild Colorado potato beetles was compared with that of toads exposed to genetic mutant Colorado potato beetles without elytral stripes. Tests confirmed the distastefulness of adult and larval stages and demonstrated the development of prey avoidance (cessation of feeding in spite of hunger) combined or not to behavioural displays where the toad plants down, crouches, and turns away or shows wincing, prey dropping, and mouth gaping after snapping at the beetle. However, toads showed the same response to mutant adult beetles without stripes and to mutant larval beetles without the red colour as to wild adult beetles with stripes and to wild red larvae. Results indicate that the stripes and the red colouration of the Colorado potato beetle do not constitute aposematic characters for the toad.
Wolf body mass, skull morphology, and mitochondrial DNA haplotypes in the Riding Mountain National Park region of Manitoba, Canada
Authors: Stronen Astrid V. , Forbes Graham J. , Sallows Tim , Goulet Gloria , Musiani Marco , Paquet Paul C. 
Published: May 2010

Two types of wolves, gray ( Canis lupus L., 1758) and eastern ( Canis lupus lycaon Schreber, 1775 or Canis lycaon ) or Great Lakes wolves, representing Old World (OW) and New World (NW) mitochondrial DNA (mtDNA) haplotypes, have been reported in eastern Canada and the Great Lakes region. Both haplotypes were found in Duck Mountain Provincial Park and Forest, Manitoba. Only OW haplotypes have been reported from the isolated Riding Mountain National Park (RMNP), 30 km to the south. Wolves with NW haplotypes hybridize with C. lupus and coyotes ( Canis latrans Say, 1823) and could mediate gene flow between canids. We examined available data on wolf body mass, skull morphology, and mtDNA from the RMNP region, as well as mtDNA from Manitoba and Saskatchewan, to assess the occurrence of NW haplotypes in wolves and possible canid hybridization. Mean body mass of female (n = 54) and male (n = 42) RMNP wolves during 1985–1987 was higher than that of females (n = 12) and males (n = 8) during 1999–2004. Thirteen skull measures from 29 wolf skulls did not suggest significant differences between RMNP and Duck Mountain wolves. Nineteen of 20 RMNP samples had OW haplotypes, whereas one clustered together with NW haplotypes.
THE RELATIONSHIP BETWEEN AN INNOVATION ORIENTATION AND COMPETITIVE STRATEGY
Authors: DOBNI C. BROOKE 
Published: May 2010

The strategy chosen in organizations is related to several factors including the organization's mission, objectives, resources, and its innovation orientation. Using a sample of Canadian organizations, this study examines the relationships between an organization's innovation orientation and the types of competitive strategies they pursue. An innovation orientation describes how innovative an organization is and the results suggest that such an orientation provides a context for the implementation of proactive growth-based strategies. Organizations that possess high innovation orientations engage in value creation strategies such as market segmentation, developing new products/services for new markets, and product or service customisation. Those organizations possessing low innovation orientations generally practice less aggressive and internally focused strategies, de-emphasising such things as customer service, brand reputation, and co-operation based strategies such as joint ventures and alliances.
AdCD40L Immunogene Therapy for Bladder Carcinoma—The First Phase I/IIa Trial
Authors: Malmström Per-Uno , Loskog Angelica S.I. , Lindqvist Camilla A. , Mangsbo Sara M. , Fransson Moa , Wanders Alkwin , Gårdmark Truls , Tötterman Thomas H. 
Published: May 2010

Abstract
Purpose: Immunotherapy with Bacillus Calmette-Guerin (BCG) instillation is recommended for high-risk, non–muscle invasive bladder cancer. Bacillus Calmette-Guerin is not effective in advanced tumors, and better alternatives are warranted. Immunostimulating gene therapy with adenoviral vectors expressing CD40 ligand (AdCD40L) has shown efficacy in tumor models. CD40 ligand stimulates systemic immunity and may be effective in local and invasive human disease.
Experimental Design: Patients with invasive bladder cancer scheduled for cystectomy or patients with Ta tumors were enrolled in a phase I/IIa trial. Patients were treated with three cycles of intrabladder Clorpactin WCS-90 prewash, followed by AdCD40L instillation 1 week apart. Safety, gene transfer, immune effects, and antitumor responses were monitored.
Results: All eight recruited patients were treated as scheduled, and therapy was well tolerated. The main adverse effect was transient local pain during prewash. Postoperatively, urinary tract infections and one case of late septicemia with elevated potassium were reported. No adverse events were ascribed to vector therapy. Gene transfer was detected in biopsies, and bladders were heavily infiltrated with T cells. The effector marker IFN-γ increased in biopsies, whereas levels of circulating T regulatory cells were reduced. Histologic evaluation indicated that AdCD40L therapy reduced the load of malignant cells.
Conclusions: To our knowledge, this is the first report on immunogene therapy in bladder cancer and the first using AdCD40L in vivo. Local AdCD40L gene therapy was safe, boosted immune activation, and should be further evaluated as a single or an adjuvant therapy for urothelial malignancies. Clin Cancer Res; 16(12); 3279–87. ©2010 AACR.
Echocardiography Can Identify Patients With Increased Pulmonary Vascular Resistance by Assessing Pressure Reflection in the Pulmonary Circulation
Authors: Bech-Hanssen Odd , Lindgren Fredrik , Selimovic Nedim , Rundqvist Bengt 
Published: May 2010

Background—
Pulmonary hypertension is a frequent finding in patients with cardiopulmonary disorders. It is important to recognize pulmonary hypertension due to increased pulmonary vascular resistance (PVR), as this affects treatment and prognosis. Patients with increased PVR have an increased pulmonary pressure reflection. We hypothesized that pressure reflection can be described by echocardiography and that variables related to pressure reflection can identify patients with increased PVR.

Methods and Results—

The study comprised 98 patients investigated within 24 hours of right heart catheterization and 20 control subjects. The pressure reflection variables were obtained by pulsed Doppler in the pulmonary artery and continuous Doppler of tricuspid regurgitation. We selected 3 variables related to pressure reflection: the interval from valve opening to peak velocity in the pulmonary artery (AcT, ms), the interval between pulmonary artery peak velocity and peak tricuspid velocity (tPV-PP, ms), and the right ventricular pressure increase after peak velocity in the pulmonary artery (augmented pressure, AP, mm Hg). The correlation between simultaneous catheter- and echocardiography-determined AP was strong (n=19,
R
=0.83). The AcT, tPV-PP, and AP in patients with a PVR of >3 Woods units (n=71) was (mean±SD) 77±16 ms, 119±36 ms, and 22±12 mm Hg, respectively, and differed from patients with a PVR of ≤3 Woods units (n=27,
P
<0.0001), 111±32 ms, 39±54 ms, and 3±4 mm Hg, and from controls, 153±32 ms, −19±45 ms, and 0 mm Hg, respectively (
P
<0.0001). The AcT, tPV-PP, and AP values were not correlated with capillary wedge pressure (
R
=0.08–0.16). The areas under the receiver operator characteristic curve (95%CI) for AcT, tPV-PP, and AP were 0.87 (0.82 to 0.95), 0.94 (0.89 to 0.99), and 0.98 (0.95 to 1.0), respectively.

Conclusions—
In this study, we describe a novel echocardiography method for assessing pressure reflection in the pulmonary circulation. This method can be used to identify patients with pulmonary hypertension due to increased PVR.
Seasonal Predictability of Daily Rainfall Characteristics in Central Northern Chile for Dry-Land Management
Authors: Verbist Koen , Robertson Andrew W. , Cornelis Wim M. , Gabriels Donald 
Published: May 2010

Abstract
The seasonal predictability of daily winter rainfall characteristics relevant to dry-land management was investigated in the Coquimbo region of central northern Chile, with focus on the seasonal rainfall total, daily rainfall frequency, and mean daily rainfall intensity on wet days at the station scale. Three approaches of increasing complexity were tested. First, an index of the simultaneous El Niño–Southern Oscillation (ENSO) was regressed onto May–August (MJJA) observed precipitation; this explained 32% of station-averaged rainfall-amount variability, but performed poorly in a forecasting setting. The second approach used retrospective seasonal forecasts made with three general circulation models (GCMs) to produce downscaled seasonal rainfall statistics by means of canonical correlation analysis (CCA). In the third approach, a nonhomogeneous hidden Markov model (nHMM) driven by the GCM’s seasonal forecasts was used to model stochastic daily rainfall sequences. While the CCA is used as a downscaling method for the seasonal rainfall characteristics themselves, the nHMM has the ability to simulate a large ensemble of daily rainfall sequences at each station from which the rainfall statistics were calculated. Similar cross-validated skill estimates were obtained using both the CCA and nHMM, with the highest correlations with observations found for seasonal rainfall amount and rainfall frequency (up to 0.9 at individual stations). These findings were interpreted using analyses of observed rainfall spatial coherence, and by means of synoptic rainfall states derived from the HMM. The downscaled hindcasts were then tailored to meteorological drought prediction, using the standardized precipitation index (SPI) based on seasonal values, the frequency of substantial rainfall days (&gt;15 mm; FREQ15) and the daily accumulated precipitation deficit. Deterministic hindcasts of SPI showed high hit rates, with high ranked probability skill score for probabilistic hindcasts of FREQ15 obtained via the nHMM.
The Three-Dimensional Axisymmetric Wind Field Structure of the Spencer, South Dakota, 1998 Tornado
Authors: Kosiba Karen , Wurman Joshua 
Published: May 2010

Abstract
The three-dimensional axisymmetric wind field structure of the violent Spencer, South Dakota, 1998 tornado was analyzed using the ground-based velocity track display (GBVTD) method. Data from a Doppler on Wheels mobile radar, collected at very close range to the tornado, were used to conduct the GBVTD calculations at a very fine (16 m) resolution. The analysis revealed a two-cell vortex with a very strong axial downdraft throughout the observation period, radial inflow jets preceding intensification and a decrease in inflow preceding weakening, swirl ratio values consistent with observed multiple vortex structure, and other features of the vortex.
Mechanisms of Along-Valley Winds and Heat Exchange over Mountainous Terrain
Authors: Schmidli Juerg , Rotunno Richard 
Published: May 2010

AbstractThe physical mechanisms leading to the formation of diurnal along-valley winds are investigated over idealized three-dimensional topography. The topography used in this study consists of a valley with a horizontal floor enclosed by two isolated mountain ridges on a horizontal plain. A diagnostic equation for the along-valley pressure gradient is developed and used in combination with numerical model simulations to clarify the relative role of various forcing mechanisms such as the valley volume effect, subsidence heating, and surface sensible heat flux effects. The full diurnal cycle is simulated using comprehensive model physics including radiation transfer, land surface processes, and dynamic surface–atmosphere interactions. The authors find that the basic assumption of the valley volume argument of no heat exchange with the free atmosphere seldom holds. Typically, advective and turbulent heat transport reduce the heating of the valley during the day and the cooling of the valley during the night. In addition, dynamically induced valley–plain contrasts in the surface sensible heat flux can play an important role. Nevertheless, the present analysis confirms the importance of the valley volume effect for the formation of the diurnal along-valley winds but also clarifies the role of subsidence heating and the limitations of the valley volume effect argument. In summary, the analysis brings together different ideas of the valley wind into a unified picture.
The Pacific’s Response to Surface Heating in 130 Yr of SST: La Niña–like or El Niño–like?
Authors: Tung Ka-Kit , Zhou Jiansong 
Published: May 2010

Abstract
Using a modified method of multiple linear regression on instrumented sea surface temperature (SST) in the two longest historical datasets [the Extended Reconstructed SST dataset (ERSST) and the Met Office Hadley Centre Sea Ice and SST dataset (HadISST)], it is found that the response to increased greenhouse forcing is a warm SST in the mid- to eastern Pacific Ocean in the equatorial region in the annual or seasonal mean. The warming is robustly statistically significant at the 95% confidence level. Consistent with this, the smaller radiative heating from solar forcing produces a weak warming also in this region, and the spatial pattern of the response is neither La Niña–like nor El Niño–like. It is noted that previous reports of a cold-tongue (La Niña–like) response to increased greenhouse or to solar-cycle heating were likely caused by contaminations due to the dominant mode of natural response in the equatorial Pacific. The present result has implications on whether the Walker circulation is weakened or strengthened in a warmer climate and on coupled atmosphere–ocean climate model validation.
Upscale Feedback of Tropical Synoptic Variability to Intraseasonal Oscillations through the Nonlinear Rectification of the Surface Latent Heat Flux*
Authors: Zhou Chunhua , Li Tim 
Published: May 2010

Abstract
Analysis of observational data suggests two-way interactions between the tropical intraseasonal oscillation (ISO) and synoptic-scale variability (SSV). On one hand, SSV is strongly modulated by the ISO; that is, a strengthened (weakened) SSV appears during the enhanced (suppressed) ISO phase. The northwest–southeast-oriented synoptic wave train is strengthened and well organized in the northwestern Pacific during the enhanced ISO phase but weakened during the suppressed ISO phase. On the other hand, SSV may exert an upscale feedback to ISO through the nonlinearly rectified surface latent heat flux (LHF). The maximum synoptic contribution exceeds 20%–30% of the total intraseasonal LHF over the tropical Indian Ocean, western Pacific, and northeastern Pacific. The nonlinearly rectified LHF leads the ISO convection and boundary layer specific humidity, and thus it may contribute to the propagation of the ISO in boreal summer through the preconditioning of the surface moisture and moist static energy ahead of the convection.
Time–Frequency Characteristics of Regional Climate over Northeast China and Their Relationships with Atmospheric Circulation Patterns
Authors: Liu Shi , Yang Song , Lian Yi , Zheng Dawei , Wen Min , Tu Gang , Shen Baizhu , Gao Zongting , Wang Donghai 
Published: May 2010

Abstract
The time–frequency characteristics of the variations of temperature and precipitation over the city of Changchun in northeast China and their associations with large-scale atmospheric and oceanic conditions are analyzed. It is found that the variations of the regional climate are characterized by strong semiannual signals. For precipitation, the amplitude of semiannual signal is about half of that of the annual cycle. The relationships of the Changchun temperature and precipitation with local winds and large-scale patterns of atmospheric circulation and sea surface temperature are also strongest on annual and semiannual time scales. These strong semiannual signals are potentially helpful for improving the prediction of the regional climate.
On the annual time scale, the northeast China climate is affected by both the thermal contrast between the Asian continent and the tropical Indo-Pacific Oceans and that between the continent and the extratropical North Pacific. These effects are manifested by the cyclonic (anticyclonic) pattern over the Asian continent (North Pacific) and the strong southerly flow over East Asia and northwestern Pacific associated with increases in temperature and precipitation. On the semiannual time scale, the northeast China climate is mainly related to the large-scale circulation pattern centered over the North Pacific, with its western portion over northeast China, North and South Korea, and Japan. While temperature signals are related to extratropical atmospheric process more apparently, both extratropical and tropical influences are seen in the semiannual variation of precipitation.
There exist strong relationships between Changchun temperature and precipitation and the North Pacific Oscillation (NPO) in the frequency band up to 7 months. Temperature increases and precipitation decreases when NPO is positive. The relationships were weak before 1980 but became stronger afterward, associated with the strengthening of the East Asian trough.