bluuebunny/crossref_metadata_2025_split huggingface dataset:
Development of bullous systemic lupus erythematosus in patient treated with NB‐UVB: A case report and comprehensive review of the literature
Authors: Behrangi Elham , Jafarzadeh Alireza , Dehghani Abbas , Shayanfar Nasrin , Goodarzi Azadeh 
Published: June 2024

Key Clinical MessageThe use of phototherapy is highly effective in treating various skin diseases. In this study, the aim is to present vesicular and blister lesions in patients treated with UVB for psoriasis. It is advisable to consider the possibility of BSLE in cases of vesiculobullous lesions following phototherapy, along with other potential diagnoses.AbstractBullous systemic lupus erythematosus (BSLE) is a rare form of cutaneous lupus erythematosus that presents as vesicles and blisters on various parts of the body. The pathological appearance of these lesions often shows subepidermal vesicles with deposits of IgG, IgM, IgA, and complement C3 in granular or linear forms under direct immunofluorescence (DIF) examination. Clinical studies demonstrate the effectiveness of phototherapy in treating various skin conditions. While several studies suggest a correlation between phototherapy and the development of vesiculobullous lesions, most of these reports are related to bullous pemphigoid, with limited research on the occurrence of BSLE following phototherapy. In this case report, vesicular and blistering lesions in a 70‐year‐old man undergoing UVB treatment for psoriasis are described. Pathological examination confirmed the diagnosis of bullous systemic lupus erythematosus, and the patient experienced significant improvement after treatment with dapsone tablets. A literature review was conducted on the development of vesiculobullous lesions after phototherapy, comparing different approaches presented in previous studies. Our conclusion highlights the importance of considering BSLE as a possible diagnosis in cases of vesiculobullous lesions post‐phototherapy, alongside other potential conditions.
Case report of streptococcal infection as a potential precipitating factor in cutaneous polyarteritis nodosa in pediatric patients
Authors: Tabibi Pooneh , Shiari Reza , Shafiee Ali , Rahmani Khosro , Saravi Niloofar 
Published: June 2024

Key Clinical MessageThis pediatric case report underscores the importance of maintaining a high clinical suspicion for polyarteritis nodosa (PAN) in patients presenting with atypical features, such as migratory arthritis and subcutaneous nodules. Importantly, it highlights the focus on the potential relationship between streptococcal infection and cutaneous PAN. Early recognition and prompt, aggressive treatment is critical, as PAN can be a life‐threatening condition if left unmanaged. This case emphasizes the need for a multidisciplinary approach to effectively identify and manage this rare vasculitis disorder in the pediatric population.AbstractPolyarteritis nodosa (PAN) is a rare and life‐threatening vasculitis with diverse clinical presentations, posing a diagnostic challenge. Early recognition and prompt intervention are crucial to prevent organ damage. We present the case of an 8‐year‐old boy who exhibited atypical symptoms including migratory arthritis, myalgia, digital discoloration and ischemic changes, and subcutaneous nodules. Initial concerns for septic arthritis were ruled out. A comprehensive evaluation revealed elevated inflammatory markers and a confirmatory skin biopsy demonstrating active leukocytoclastic vasculitis, are highly suggestive of a diagnosis of PAN. Notably, elevated ASO titers suggested a possible concurrent streptococcal infection. The aggressive treatment approach with high‐dose aspirin, steroids, methotrexate, and tocilizumab is justified given the severity of the patient's symptoms and the nature of the disease process. This case underscores the importance of considering PAN in the differential diagnosis for children presenting with atypical features. Early diagnosis and prompt intervention, including addressing potential infectious triggers, are crucial for optimal outcomes in pediatric PAN.
g‐C3N4‐Based Photocatalytic Materials for Converting CO2 Into Energy: A Review
Authors: Zhang Ping , Li Ning , Li Longjian , Yu Yongchong , Tuerhong Reyila , Su Xiaoping , Zhang Bin , Han Lijuan , Han Yuqi 
Published: June 2024

AbstractEnvironmental pollution management and renewable energy development are humanity‘s biggest issues in the 21st century. The rise in atmospheric CO2, which has surpassed 400 parts per million, has stimulated research on CO2 reduction and conversion methods. Presently, photocatalytic conversion of CO2 to valuable hydrocarbons enables the transformation of solar energy into chemical energy and offers a novel avenue for energy conversion while regulating the greenhouse effect. This is an ideal strategy for simultaneously addressing environmental issues and the energy crisis. Photocatalysts are essential to photocatalytic processes. Photocatalyst is the core of photocatalytic technology, and graphite carbon nitride (g‐C3N4) has attracted much attention because of its nonmetallic characteristics, and it has the characteristics of low cost, tunable electronic structure, easy manufacture and strong reducibility. However, its activity is not only affected by external reaction conditions, but also by the band gap structure, physical and chemical stability, surface morphology and specific surface area of the photocatalyst it. In this paper, the application progress of g‐C3N4‐based photocatalytic materials in CO2 reduction is reviewed, and the modification strategies of g‐C3N4‐based catalysts to obtain better catalytic efficiency and selectivity in CO2 photocatalytic reduction are summarized, and the future development of this material is prospected.
Robust model predictive control of virtual synchronous generators without weighting factors
Authors: Wang Su'e , Liu Yufan , Zhang Shuai , Hao Pengfei , Liu Jun 
Published: June 2024

SummaryVirtual synchronous generators (VSGs) can provide damping and inertia for new power systems are of wide interest. Model predictive control (MPC) has the advantages of simple structure, easy to deal with constraints, and can achieve multi‐objective control. However, the conventional MPC has the problems of relying on the model parameters as well as the difficulty of taking the values of the weighting factors. Based on this, this paper proposes a robust MPC control strategy without weighting factors, which improves the system robustness by identifying the model parameters through model reference adaptive system (MRAS); and introduces fuzzy decision making (FDM) to avoid the selection of weighting factors. First, the mathematical model of VSG is established and the prediction model of VSG multi‐objective control is derived. Second, a detailed analysis is conducted to examine the impact of parameter mismatch on VSG. Third, the expression for online identification of parameters is derived based on Popov's superstability theory, using FDM to optimize multi‐objective control and using decision functions instead of cost functions to avoid the selection of weighting factors. Finally, the effectiveness of the proposed control strategy is verified through the RT‐LAB semi‐physical platform.
Customizing an all‐in‐one polydimethylsiloxane‐based electroanalytical platform using a 3D‐pen templated channel
Authors: Silva do Carmo Jéssica da , Roveda Liriana Mara , Rodrigues Raphael , de Carvalho Cláudio Teodoro , Trindade Magno Aparecido Gonçalves 
Published: June 2024

AbstractThe combination of 3D‐printing technology and microfluidics has garnered widespread interest for creating new designs and has opened a large window for creativity. However, some laboratories do not have the necessary technology to explore this potential advantage. In this paper, we demonstrate how to explore target technologies to fabricate a single version of a polydimethylsiloxane (PDMS)‐based electroanalytical platform using a low‐cost protocol and disposable materials. This protocol is cost‐effective in terms of equipment and materials, allowing for the creation of a circular channel, a T‐junction system, and two designs of electrochemical detectors customized onto a single platform. The interesting new device has some important characteristics, such as fabrication following green and sustainable protocols. Additionally, it can address the limitations associated with flow‐based analysis, for which the classical three‐electrode configuration is inadequate. It has also demonstrated the feasibility of using the device in analytical applications for the determination of salicylic acid in commercial dermocosmetic samples, including aqueous samples.
Attitudes to long‐term care in India: A secondary, mixed methods analysis
Authors: Alberts Sweedal , Nadarajah Abinaya , Cooper Claudia , Brijnath Bianca , Loganathan Santosh , Varghese Matthew , Antoniades Josefine , Baruah Upasana , Dow Briony , Kent Mike , Rao Rachita , Budgett Jessica , Ahmed Amaani 
Published: June 2024

AbstractObjectivesIn India, globalisation is purported to have contributed to shifting family structures and changing attitudes to long‐term care (LTC) facility use. We investigated the attitudes to and usage frequency of LTC in India.MethodsWe conducted secondary analyses of: (a) The Moving Pictures India Project qualitative interviews with 19 carers for people with dementia and 25 professionals, collected in 2022, exploring attitudes to LTC; and (b) The Longitudinal Ageing Study in India (LASI) 2017–2018, cross‐sectional survey of a randomised probability sample of Indian adults aged 45+ living in private households.ResultsWe identified three themes from qualitative data: (1) LTC as a last resort, describes how LTC could be acceptable if care at home was “impossible” due to the person's medical condition or unavailability of the family carer, for example, if family members lived overseas or interstate. (2) Social expectations of care at home from family members and paid carers and; (3) Limited availability of LTC facilities in India, especially in rural localities, and the financial barriers to their use. Of 73,396 LASI participants, 40 were considering moving to LTC; 18,281 had a parent alive, of whom 9 reported that their father, and 16 that their mother, lived in LTC. LTC use was rare. While a third of participants with a living parent lived in urban areas, 14/24 of those with a parent in LTC lived in an urban area, supporting our qualitative findings that LTC is mainly accessed in urban areas.ConclusionsPreference for intergenerational community care combined with limited availability and societal stigma contribute to low rates of LTC use among Indian families. Future social policies should consider how to plan for greater equity in strengthening care at home and in the community, and bolstering respite and LTC services as a last resort.
The effect of birth timing manipulation around carnival on birth indicators in Brazil
Authors: Melo Carolina , Menezes‐Filho Naercio 
Published: June 2024

AbstractThis paper studies the patterns and consequences of birth timing manipulation around the carnival holiday in Brazil. We document how births are displaced around carnival and estimate the effect of displacement on birth indicators. We show that there is extensive birth timing manipulation in the form of both anticipation and postponement that results in a net increase in gestational length and reductions in neonatal and early neonatal mortality, driven by postponed births that would otherwise happen through scheduled c‐sections. We also find a reduction in birthweight for high‐risk births at the bottom of the weight distribution, driven by anticipation. Therefore, restrictions on usual delivery procedures due to the carnival holiday can be both beneficial and detrimental, raising a double‐sided issue to be addressed by policymakers.
A comparison of Mersilene tape versus braided suture in transvaginal cervical cerclage: A retrospective case–control study
Authors: Xu Zhi‐Min , Lin Dan , Zhang Jun , Zheng Yi‐Jing , Liu Jing , Zhang Lin , Pan Mian 
Published: June 2024

AbstractObjectivePrevious studies have indicated that there is an association between cervical cerclage and type of suture material. However, it is still unclear which suture material can provide the greatest benefit to patients who have undergone cerclage. This study investigated the effect of two different suture materials (Mersilene tape vs braided suture) used for transvaginal cervical cerclage placement on maternal outcomes of women with cervical insufficiency.MethodsIn this retrospective case–control study, 170 women who underwent history‐, ultrasound‐, or physical examination‐indicated transvaginal cervical cerclage were categorized according to suture materials used for cerclage: a total of 96 received Mersilene tape and 74 received braided suture. Study participants received a transvaginal cervical cerclage before 28 weeks and were followed up until delivery to assess pregnancy and neonatal outcomes. The primary outcome was gestational age at delivery. Secondary outcomes included preterm premature rupture of membranes (PPROM), premature rupture of membranes (PROM), chorioamnionitis, neonatal survival rate, and neonatal morbidity.ResultsOut of 170 eligible women, 74 (43.5%) received braided suture while 96 (56.5%) received Mersilene tape. Baseline characteristics were similar between the two groups. The group that received braided suture had a lower incidence of gestational age at delivery <37 weeks (29.2% vs 54.2%, P = 0.046), PPROM (9.5% vs 21.9%, P = 0.029) and PROM (17.6% vs 32.3%, P = 0.028) compared to the group that received Mersilene tape. However, there were no significant differences between the two groups in average gestational age at delivery, the rate of gestational age at delivery <24, <28, <32, and < 34 weeks, chorioamnionitis, and neonatal survival rate, as well as neonatal morbidity.ConclusionCompared to Mersilene tape, the utilization of braided suture has been significantly associated with a reduction in the incidence of gestational age at delivery <37 weeks, as well as a decreased risk of PPROM and PROM. However, the use of braided sutures did not result in discernible differences in the rates of chorioamnionitis or adverse neonatal outcomes.
Genome‐wide CRISPR screening identifies the pivotal role of ANKRD42 in colorectal cancer metastasis through EMT regulation
Authors: Liu Shengde , Zhang Zizhen , Wang Zhenghang , Li Jian , Shen Lin 
Published: June 2024

AbstractColorectal cancer (CRC), a pervasive and lethal malignancy of gastrointestinal cancer, imposes significant challenges due to the occurrence of distant metastasis in advanced stages. Understanding the intricate regulatory mechanisms driving CRC distant metastasis is of paramount importance. CRISPR‐Cas9 screening has emerged as a powerful tool for investigating tumor initiation and progression. However, its application in studying CRC distant metastasis remains largely unexplored. To establish a model that faithfully recapitulates CRC liver metastasis in patients, we developed an in vivo genome‐wide CRISPR‐Cas9 screening approach using a spleen‐injected liver metastasis mouse model. Through comprehensive screening of a whole‐genome sgRNA library, we identified ANKRD42 as a pivotal regulatory gene facilitating CRC liver metastasis. Analysis of the TCGA database and our clinical cohorts unveiled heightened ANKRD42 expression in metastases. At the cellular level, the attenuation of ANKRD42 impaired the migration and invasion processes of tumor cells. In vivo experiments further validated these observations, highlighting the diminished liver metastatic capacity of tumor cells upon ANKRD42 knockdown. To unravel the specific mechanisms by which ANKRD42 regulates CRC distant metastasis, we leveraged patient‐derived organoid (PDO) models. Depleting ANKRD42 in PDOs sourced from liver metastases precipitated the downregulation of pivotal genes linked to epithelial‐mesenchymal transition (EMT), including CDH2 and SNAI2, thereby effectively suppressing tumor metastasis. This study not only establishes a conceptual framework but also identifies potential therapeutic avenues for advanced‐stage distant metastasis in CRC patients.
MiR‐3680‐3p is a novel biomarker for the diagnosis and prognosis of liver cancer and is involved in regulating the progression of liver cancer
Authors: Tang Jie , Li Song , Zhou Zixiao , Wang Yongqiang , Ni DeSheng , Zhou Shaobo 
Published: June 2024

AbstractMicroRNAs (miRNAs) are small non‐coding RNAs that can actively participate in post‐transcriptional regulation of genes. A number of studies have shown that miRNAs can serve as important regulators of cancer cell growth, differentiation, and apoptosis. They can also act as markers for the diagnosis and prognosis of certain cancers. To explore the potential prognosis‐related miRNAs in liver cancer patients, to provide theoretical basis for early diagnosis and prognosis of liver cancer, as well as to provide a new direction for the targeted therapy of liver cancer. The miRNA expression profiles of liver cancer patients in the the Cancer Genome Atlas database were comprehensively analyzed and various prognostic‐related miRNAs of liver cancer were screened out. The data was further subjected to survival analysis, prognostic analysis, gene ontology and kyoto encyclopedia of genes and genomes enrichment analysis, microenvironment analysis, and drug sensitivity analysis by R Language version 4.2.0. Finally, the screened miRNAs were further validated by different experiments. Thus, miNRAs involved in liver cancer diagnosis and prognosis were identified. MiRNA‐3680‐3p was found to be significantly different in 10 different cancers, including liver cancer, and was significantly associated with the microenvironment, survival, and prognosis of liver cancer patients. In addition, drug sensitivity analysis revealed that miRNA‐3680‐3p can provide a useful reference for drug selection in targeted therapy for liver cancer. MiRNA‐3680‐3p can serve as a biomarker for the diagnosis and prognosis of liver cancer patients and down‐regulation of miRNA‐3680‐3p could significantly inhibit both the proliferation and migration of liver cancer cells.
Neuroprotection and mechanisms of ginsenosides in nervous system diseases: Progress and perspectives
Authors: Zhou Li , Tan Feilong , Zhang Xue , Li Yanhua , Yin Wenjie 
Published: June 2024

AbstractGinsenosides are the primary component discernible from ginseng, including Rb1, Rb2, Rd, Rg1, Rg2, and compound K, and so forth. They have been shown to have multiple pharmacological activities. In recent years, more and more studies have been devoted to the neuroprotection of various ginsenosides against neurological diseases and their potential mechanisms. This paper comprehensively summarizes and reviews the neuroprotective effects of various ginsenosides on neurological diseases, especially acute and chronic neurodegenerative diseases, and their mechanisms, as well as their potential therapeutic applications to promote neuroprotection in disease prevention, treatment, and prognosis. Briefly, ginsenosides exert effective neuroprotective effects on neurological conditions, including stroke, Alzheimer's disease, Parkinson's disease, and brain/spinal cord injuries through a variety of molecular mechanisms, including anti‐inflammatory, antioxidant, and anti‐apoptotic. Among them, some signaling pathways play important roles in related processes, such as PI3K/Akt, TLR4/NF‐κB, ROS/TXNIP/NLRP3, HO‐1/Nrf2, Wnt/β‐catenin, and Ca2+ pathway. In conclusion, the present study reviews the research progress on the neuroprotective effects of ginsenosides in the last decade, with the aim of furnishing essential theoretical underpinning and effective references for further research and exploration of the multiple medicinal values of Chinese herbal medicines and their small molecule compounds, including ginseng and panax ginseng. Because there is less evidence in the existing clinical studies, future research should be focused on clinical trials in order to truly reflect the clinical value of various ginsenosides for the benefit of patients.
Validation of the German long and short versions of the UPPS‐P Impulsive Behavior Scale
Authors: Wüllhorst Verena , Lützkendorf Julia , Endrass Tanja 
Published: June 2024

AbstractObjectiveThe UPPS‐P Impulsive Behavior Scale is a widely used self‐report measure of impulsivity, but there is currently no validated German version that includes the Positive Urgency scale.MethodsWe combined existing German translations of UPPS scales and included the Positive Urgency dimension to validate the UPPS‐P in a sample of 399 participants. In addition, we developed a revised short version of the UPPS‐P (SUPPS‐P) with 20 items and conducted a confirmatory factor analysis (CFA) to verify the structure in an independent validation sample with 349 participants. To determine evidence of convergent and discriminant validity, we used measures of impulsivity, depression, anxiety, stress, problematic alcohol and substance use.ResultsCFA of the five factorial structure of the UPPS‐P demonstrated acceptable fits and evidence of validity and reliability for the subscales. Psychometric characteristics of the SUPPS‐P using the original item configuration were not satisfactory. As a result, we developed a revised German version of the SUPPS‐P and confirmed the five‐factor structure using a CFA in the validation sample. For the revised version, model fits and evidence of validity and internal consistencies were good. Associations with other constructs were as expected. For example, whereas Sensation Seeking was associated moderately with problematic alcohol use, lacking associations of Lack of Premeditation to internalizing symptoms showed evidence of discriminant validity.DiscussionThe German translations of both UPPS‐P and SUPPS‐P are valid tools for measuring impulsive behaviors. They are well‐suited for exploring the associations between different facets of impulsivity and psychopathological phenomena.
Moving to a new normal: Analysis of shifting climate normals in New Zealand
Authors: Srinivasan Raghav , Carey‐Smith Trevor , Wang Linda , Harper Andrew , Dean Sam , Macara Gregor , Wang Ruotong , Stuart Stephen 
Published: June 2024

AbstractNew Zealand's National Institute of Water and Atmospheric Research publishes climate normals for New Zealand that are used for reporting the regional state of the climate, climate extremes and variability. Temperature and precipitation patterns are affected by both anthropogenic climate change and natural climate variability which in turn affect the climatological normal values calculated every decade. This study investigates how New Zealand's normals for temperature and precipitation have shifted over time at the national, regional and seasonal scales from the 1941–1970 period to the 1991–2020 period. Contrary to WMO recommendations, but aligned with many other countries, New Zealand's climate normals have traditionally not undergone homogenisation. The impact of introducing some homogenisation in the latest 1991–2020 normals, in contrast to historical non‐homogenized station normals, has been assessed using a new homogenized “Seventeen‐Station” temperature series from 1941 to 2020. We demonstrate that interpolating sparse non‐homogenized normals spatially to a grid can produce significant erroneous patterns and therefore undermine the accuracy of the conclusions drawn when using such normals. We find that the historical non‐homogenized temperature normals have a consistent negative bias in the long‐term trend at national, regional and seasonal scales. Our analysis of homogeneity tested precipitation showed consistent decreases at a national scale across all normal periods relative to the 1951–1980 precipitation normal. We also highlight how fixed period temperature and precipitation normals do not fully reflect the current state of a climate that is influenced by decadal variability and global warming. To derive normals fit for use in a changing climate it is suggested that automated methods for broad data homogenisation be developed along with alternative methods to derive normals that account for a non‐stationary climate.