bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dynamic color‐tunable ultra‐long room temperature phosphorescence polymers with photo‐chromism and water‐stimuli response for multilevel anti‐counterfeiting
Authors: Ma Xiao , Ye Tian‐Jiao , Yang Han‐Jiang , Ling Guang‐Kun , Wang Danfeng , Li Jia‐Shu , Gu Peiyang , Xu Liang‐Jin , Sheng Tian‐Lu , Lin Fu‐Rong , Shen Run‐Fu , Zhang Qichun 
Published: May 2024

AbstractDeveloping dynamic color‐tunable ultra‐long room temperature phosphorescence (URTP) polymers with afterglow of over 1 s, photo‐chromism, and multi‐stimuli response for practical anti‐counterfeiting and information security applications is attractive but very challenging. Herein, by doping multicolor phosphorescence pyridinium bromide L block or viologen‐based photo‐chromic V block into polyvinyl alcohol matrixes, the water‐stimuli‐responsive color‐tunable URTP polymer films with afterglow of up to 8 s and the reversible viologen‐based photochromic polymer films have been developed. More significantly, a series of dynamic color‐tunable URTP polymer films with ultra‐long afterglow of over 6 s, photo‐chromism, and water‐stimuli response have been successfully exploited by integrating L and V blocks into one polymer system. Mechanistic investigations have revealed that their photo‐chromism mainly comes from the photo‐generated viologen free radicals. Furthermore, their dynamic multilevel anti‐counterfeiting applications have been demonstrated. These results pave the way to develop smarter multifunctional URTP materials for anti‐counterfeiting and optical sensing.
Stabilizing Zn/electrolyte Interphasial Chemistry by a Sustained‐Release Drug Inspired Indium‐Chelated Resin Protective Layer for High‐Areal‐Capacity Zn//V2O5 Batteries
Authors: Zhang Minghao , Li Siyang , Tang Rong , Sun Chenxi , Yang Jin , Chen Guanhong , Kang Yuanhong , Lv Zeheng , Wen Zhipeng , Li Cheng Chao , Zhao Jinbao , Yang Yang 
Published: May 2024

AbstractFor zinc‐metal batteries, the instable chemistry at Zn/electrolyte interphasial region results in severe hydrogen evolution reaction (HER) and dendrite growth, significantly impairing Zn anode reversibility. Moreover, an often‐overlooked aspect is this instability can be further exacerbated by the interaction with dissolved cathode species in full batteries. Here, inspired by sustained‐release drug technology, an indium‐chelated resin protective layer (Chelex‐In), incorporating a sustained‐release mechanism for indium, is developed on Zn surface, stabilizing the anode/electrolyte interphase to ensure reversible Zn plating/stripping performance throughout the entire lifespan of Zn//V2O5 batteries. The sustained‐release indium onto Zn electrode promotes a persistent anticatalytic effect against HER and fosters uniform heterogeneous Zn nucleation. Meanwhile, on the electrolyte side, the residual resin matrix with immobilized iminodiacetates anions can also repel detrimental anions (SO42− and polyoxovanadate ions dissolved from V2O5 cathode) outside the electric double layer. This dual synergetic regulation on both electrode and electrolyte sides culminates a more stable interphasial environment, effectively enhancing Zn anode reversibility in practical high‐areal‐capacity full battery systems. Consequently, the bio‐inspired Chelex‐In protective layer enables an ultralong lifespan of Zn anode over 2800 h, which is also successfully demonstrated in ultrahigh areal capacity Zn//V2O5 full batteries (4.79 mAh cm−2).
Local Self‐Assembly of Dissipative Structures Sustained by Substrate Diffusion
Authors: Kar Haridas , Goldin Lorenzo , Frezzato Diego , Prins Leonard J. 
Published: May 2024

AbstractThe coupling between energy‐consuming molecular processes and the macroscopic dimension plays an important role in nature and in the development of active matter. Here, we study the temporal evolution of a macroscopic system upon the local activation of a dissipative self‐assembly process. Injection of surfactant molecules in a substrate‐containing hydrogel results in the local substrate‐templated formation of assemblies, which are catalysts for the conversion of substrate into waste. We show that the system develops into a macroscopic (pseudo‐)non‐equilibrium steady state (NESS) characterized by the local presence of energy‐dissipating assemblies and persistent substrate and waste concentration gradients. For elevated substrate concentrations, this state can be maintained for more than 4 days. The studies reveal an interdependence between the dissipative assemblies and the concentration gradients: catalytic activity by the assemblies results in sustained concentration gradients and, vice versa, continuous diffusion of substrate to the assemblies stabilizes their size. The possibility to activate dissipative processes with spatial control and create long lasting non‐equilibrium steady states enables dissipative structures to be studied in the space‐time domain, which is of relevance for understanding biological systems and for the development of active matter.
ObsTIVA‐UK: a service evaluation of obstetric total intravenous anaesthesia in the United Kingdom
Authors: Metodiev Y. , Iliff H. A. , Sharif B. , Bell S. F. , Oliver C. , de Lloyd L. ,   ObsTIVA‐UK Collaborators Group
Published: May 2024

SummaryWe conducted a prospective observational service evaluation across the United Kingdom on the use of total intravenous anaesthesia (TIVA) for obstetric surgery between November 2022 and June 2023. The primary aim was to describe the incidence of TIVA for obstetric surgery within participating units, with secondary aims to describe maternal and neonatal postoperative recovery indicators. Of 184 maternity units in the United Kingdom, 30 (16%) contributed data to the service evaluation. There were 104 patients who underwent caesarean delivery under TIVA and 19 patients had TIVA for other reasons. Infusions of propofol and remifentanil were used in 100% and 84% of cases, respectively. Fifty‐nine out of 103 live neonates (57%) required some form of respiratory support. Of the neonates with recorded data, 73% and 17% had Apgar scores < 7 at 1 and 5 min respectively. No neonates were recorded to have Apgar scores < 7 at 10 min. Further prospective research is required to investigate the impact of obstetric TIVA on maternal and neonatal outcomes and inform best practice recommendations.
GPR and ERT Exploration in the Western Cemetery in Giza, Egypt
Authors: Sato Motoyuki , Saito Ryuma , Abbas Abbas Mohamed , Mesbah Hany , Taha Ayman , Gaweish Wael R. , Aldeep Mohamed , Ali Ahmed M. , Kurokouchi Hiromasa , Takahashi Kazumitsu , El‐Qady Gad , Yoshimura Sakuji 
Published: May 2024

ABSTRACTA geophysical exploration employing ground‐penetrating radar (GPR) and electrical resistivity tomography (ERT) was conducted at the Western Cemetery, Giza, Egypt, in 2021–23 by a joint research team of Higashi Nippon International University, Tohoku University and the National Research Institute of Astronomy and Geophysics (NRIAG), Helwan, Egypt. We believe we found an anomaly: a combination of a shallow structure connected to a deeper structure. The shallow structure, which is L‐shaped in the horizontal plane, 10 m by 10 m, was clearly imaged by GPR. It seems to have been filled with sand, which means it was backfilled after it was constructed. It may have been an entrance to the deeper structure. Its depth is of up to 2 m, measured from the ground surface. Below this structure, ERT reveals a highly electrically resistive anomaly, which extends over an area of about 10 m by 10 m. The depth of the structure is about 5–10 m below the surface. Electrically resistive material in a sand dune can be a mixture of sand and gravel, including sparse spacing or air voids within it. Neither GPR nor ERT could identify the properties of the anomaly.
Development, implementation, and perceptions of a 3D‐printed human skull in a large dental gross anatomy course
Authors: Barger J. Bradley , Edwards Danielle N. 
Published: May 2024

AbstractSkull anatomy is a difficult region for anatomy students to learn and understand but is necessary for a variety of health professional students. To improve learning, a 3D‐printed human skull was developed, produced, and distributed to a course of 83 dental students for use as a take‐home study tool over the 10‐week anatomy course. The 70% scale human skull derived from CT data had a fully articulating mandible, simulated temporomandibular joint, and accurate cranial structures. At the course end, students completed a perception survey and responses were compared with those who made a grade of A, B, or C in the course. Students overall reported using the model less than 3 h per week, but those who scored an A in the course reported using the model more frequently than those who scored a B or C. Free responses revealed that students used the model in a variety of ways, but found that the model was quick and easily accessible to check understanding while studying at home in the absence of direct observation by faculty. Overall, this study provides evidence on the feasibility of large‐scale 3D printing and the benefits of the use of a 3D‐printed model as a take‐home study aid.
A perfusion host‐microbe bioreactor (HMB) system that captures dynamic interactions of secreted metabolites between epithelial cells cocultured with a human gut anaerobe
Authors: Yang Jingyun , Cassaday Jason , Wyche Thomas P. , Squadroni Brian , Newhard William , Trinh Huong , Cabral Damien , Hett Erik , Sana Theodore R. , Lee Kyongbum , Kasper Stephen 
Published: May 2024

AbstractThe human microbiota impacts a variety of diseases and responses to therapeutics. Due to a lack of robust in vitro models, detailed mechanistic explanations of host‐microbiota interactions cannot often be recapitulated. We describe the design and development of a novel, versatile and modular in vitro system that enables indirect coculture of human epithelial cells with anaerobic bacteria for the characterization of host‐microbe secreted metabolite interactions. This system was designed to compartmentalize anaerobes and human cells in separate chambers conducive to each organism's requisite cell growth conditions. Using perfusion, fluidic mixing, and automated sample collection, the cells continuously received fresh media, while in contact with their corresponding compartments conditioned supernatant. Supernatants from each chamber were collected in a cell‐free time‐resolved fashion. The system sustained low oxygen conditions in the anaerobic chamber, while also supporting the growth of a representative anaerobe (Bacteroides thetaiotaomicron) and a human colonic epithelial cell line (Caco‐2) in the aerobic chamber. Caco‐2 global gene expression changes in response to coculture with B. thetaiotaomicron was characterized using RNA sequencing. Extensive, targeted metabolomics analysis of over 150 central carbon metabolites was performed on the serially collected supernatants. We observed broad metabolite changes in host‐microbe coculture, compared to respective mono‐culture controls. These effects were dependent both on sampling time and the compartment probed (apical vs. basolateral). Coculturing resulted in the depletion of several important metabolites, including guanine, uridine 5'‐monophosphate, asparagine, and thiamine. Additionally, while Caco‐2 cells cultured alone predominantly affected the basolateral metabolite milieu, increased abundance of 2,3‐dihydroxyisovalerate and thymine on the basolateral side, occurred when the cells were cocultured with B. thetaiotaomicron. Thus, our system can capture the dynamic, competitive and cooperative processes between host cells and gut microbes.
Relationship between remnant cholesterol and short‐term prognosis in acute ischemic stroke patients
Authors: Tan Zheng , Zhang Qianyun , Liu Qiuwan , Meng Xiaoyin , Wu Wenpei , Wang Long , Wu Juncang 
Published: May 2024

AbstractObjectiveSeveral studies have illustrated that elevated RC levels are related to a heightened risk of acute ischemic stroke (AIS). Our research aimed to explore the correlation between RC levels and poor prognosis after a 90‐day interval in AIS patients.MethodsA total of 287 individuals were enrolled in the study, the primary outcome was defined as poor prognosis. RC was derived by the exclusion of low‐density lipoprotein cholesterol (LDL‐C) and high‐density lipoprotein cholesterol (HDL‐C) from total cholesterol (TC).ResultsFollowing the screening process, 253 AIS patients were included in the study, presenting a median age of 66[57, 75] years. Upon stratifying RC levels into quartiles, those in the top quartile faced a greater likelihood of diabetes diagnosis (42.86%, p = .014) and experienced a higher rate of unfavorable outcomes after 90 days (36.51%, p = .001). After accounting for confounding factors, the correlation between the fourth quartile of RC levels and the amplified likelihood of poor prognosis remained significant (odds ratio (OR) 8.471, 95% confidence interval (CI) (1.841, 38.985); p = .006). Analysis of subgroups unveiled a notable correlation between higher RC levels and poor 90‐day prognosis, particularly in individuals with elevated NIHSS scores (p = .044). A progressively increasing 90‐day risk of poor prognosis after an RC greater than 0.38 mmol/L was visualized by restricted cubic spline plots (p‐overall = .011).ConclusionsIncluding RC as a contributing element may refine the prediction of poor 90‐day prognosis for AIS patients. Integrating RC with traditional risk factors can potentially enhance the predictive value for cerebrovascular disease.
Relationship between recycling, circular economy and eco‐innovation in Europe. Application of a dynamic network data envelopment analysis model
Authors: García‐Valderrama Teresa , Sánchez‐Ortiz Jaime , Pérez‐González María Del Carmen , Puentes‐Graña María Del Carmen 
Published: May 2024

AbstractMonitoring of European‐level circular economy (CE) efficiency requires more research than does currently exists in the body of literature on CE. In this regard, this research aims to answer two research questions. Firstly, to be efficient in the implementation of CE at a macroeconomic level, should there be a relationship between the efficiency of the three phases of CE (efficiency in recycling, efficiency in the implementation of CE and efficiency of eco‐innovation)? To answer this question, we use decoupling theory. Secondly, are the three phases of CE related from the point of view of dynamic efficiency? To answer this question, we use dynamic efficiency theory.In accordance with both of these theories, we establish a circular relationship between recycling, CE and eco‐innovation. We test this circular relationship through the application of the dynamic network data envelopment analysis (DNDEA) model of Tone and Tsutsui. The analysis is based on Eurostat data for the period of 2016 to 2022 for 27 European countries.This work contributes to the advancement of the research via (1) the development of a model for measuring the transversal and longitudinal efficiency of the CE and (2) the findings of positive and significant relationships between the efficiency ratios of the three fundamental phases (recycling, CE and eco‐innovation). This leads us to affirm that the countries studied that have managed to be efficient in recycling have also been in the implementation phase of CE and eco‐innovation.
Can CEO's professional connections drive green innovation of SMEs?
Authors: Wang Kun , Huang Hao , Yuan Youwei 
Published: May 2024

AbstractDrawing on social capital theory, we analysis the influence of CEO's professional connections on the green innovation of SMEs. Using data from Chinese manufacturing SMEs, we find that CEO's professional connections can promote green innovation in SMEs. This finding still holds through several endogeneity and robustness tests. We find that this positive relationship is strengthened when the firm faces a more intense industry environment and when the CEO is chairman of the board. By testing the mechanism, we further find that alleviating financing constraints, improving information transparency, and promoting long‐term orientation play a key role in this positive relationship. These findings advance the research process on social capital theory and corporate green innovation and provide important insights into the green innovation practices in SMEs.
SPEED‐MODE cell line development (CLD): Reducing Chinese hamster ovary (CHO) CLD timelines via earlier suspension adaptation and maximizing time spent in the exponential growth phase
Authors: Ganapathy Kavya , Lam Cynthia , Tsukuda Joni , Sargon Alyssa , Nava Adrian , Harms Peter , Shen Amy , Barnard Gavin , Misaghi Shahram 
Published: May 2024

AbstractChinese hamster ovary (CHO) cells are the preferred system for expression of therapeutic proteins and the majority of all biotherapeutics are being expressed by these cell lines. CHO expression systems are readily scalable, resistant to human adventitious agents, and have desirable post‐translational modifications, such as glycosylation. Regardless, drug development as a whole is a very costly, complicated, and time‐consuming process. Therefore, any improvements that result in reducing timelines are valuable and can provide patients with life‐saving drugs earlier. Here we report an effective method (termed SPEED‐MODE, herein) to speed up the Cell line Development (CLD) process in a targeted integration (TI) CHO CLD system. Our findings show that (1) earlier single cell cloning (SCC) of transfection pools, (2) speeding up initial titer screening turnaround time, (3) starting suspension adaptation of cultures sooner, and (4) maximizing the time CHO cultures spend in the exponential growth phase can reduce CLD timelines from ~4 to ~3 months. Interestingly, SPEED‐MODE timelines closely match the theoretical minimum timeline for CHO CLD assuming that CHO cell division is the rate limiting factor. Clones obtained from SPEED‐MODE CLD yielded comparable titer and product quality to those obtained via a standard CLD process. Hence, SPEED‐MODE CLD is advantageous for manufacturing biotherapeutics in an industrial setting as it can significantly reduce CLD timelines without compromising titer or product quality.
Blueberry extract and its bioactive compounds mitigate oxidative stress and suppress human lung cancer cell (A549) growth by modulating the expression of p53/EGFR/STAT3/IL6‐mediated signaling molecules
Authors: Krishnamoorthy Kalaiselvi , Natarajan Sathan Raj , Veeraraghavan Vishnu Priya , Jayaraman Selvaraj 
Published: May 2024

AbstractBioactive phytocompounds are crucial components in all plants. Since the time of traditional medicine, the utilization of plants has been grounded in the potential of these bioactive compounds to treat or manage specific illnesses. These natural bioactive compounds have sparked growing interest in employing medicinal plants for addressing various conditions, such as inflammatory diseases, diabetes, and cancer. This study focuses on assessing the qualitative phytochemical composition, antioxidant potential, and cytotoxic effects of blueberry (Vaccinium sect. Cyanococcus) extract using three different solvents, namely water, ethanol, and methanol. The extract exhibited notable antioxidant activities, as evidenced by DPPH and H2O2 free radical scavenging assays. The cell viability assay also demonstrated cell growth inhibition in A549 cells. Furthermore, nine specific phytocompounds sourced from existing literature were selected for molecular docking studies against CDK6 and, AMPK key protein kinases which enhance the cancer progression. The molecular docking results also revealed favorable binding scores, with a high score of −9.5 kcal/mol in CDK6 protein and a maximum score of AMPK with targets of −8.8 kcal/mol. The selected phytocompounds’ pharmacodynamic properties such as ADMET also supported the study. Furthermore, rutin stated that pre‐dominantly present in blueberry plants shows a potent cytotoxicity effect in A549 cells. Functional annotations by bioinformatic analysis for rutin also revealed the strong enrichment in the involvement of PI3K/AKT1/STAT, and p53 signaling pathways. Based on this analysis, the identified rutin and other compounds hold a promising anticancer activity. Overall, the comprehensive evaluation of both in vitro and in silico data suggests that the Vaccinium sect. Cyanococcus extract could serve as a valuable source of pharmaceutical agents and may prove effective in future therapeutic applications.
Empagliflozin to prevent progressive adverse remodelling after myocardial infarction (EMPRESS‐MI): rationale and design
Authors: Carberry Jaclyn , Petrie Mark C. , Lee Matthew M.Y. , Brooksbank Katriona , Campbell Ross T. , Good Richard , Jhund Pardeep S. , Kellman Peter , Lang Ninian N. , Mangion Kenneth , Mark Patrick B. , McConnachie Alex , McMurray John J.V. , Meyer Barbara , Orchard Vanessa , Shaukat Aadil , Watkins Stuart , Welsh Paul , Sattar Naveed , Berry Colin , Docherty Kieran F. 
Published: May 2024

AbstractAimsPatients with a reduced left ventricular ejection fraction (LVEF) following an acute myocardial infarction (MI) are at risk of progressive adverse cardiac remodelling that can lead to the development of heart failure and death. The early addition of a sodium‐glucose cotransporter 2 (SGLT2) inhibitor to standard treatment may delay or prevent progressive adverse remodelling in these patients.Methods and resultsEMpagliflozin to PREvent worSening of left ventricular volumes and Systolic function after Myocardial Infarction (EMPRESS‐MI) is a randomized, double‐blind, placebo‐controlled, multi‐centre trial designed to assess the effect of empagliflozin on cardiac remodelling evaluated using cardiovascular magnetic resonance (CMR) in 100 patients with left ventricular systolic dysfunction following MI. Eligible patients were those ≥12 h and ≤14 days following acute MI, with an LVEF <45% by CMR. Patients were randomized to empagliflozin 10 mg once a day or matching placebo. The primary outcome will be change in left ventricular end‐systolic volume indexed to body surface area over 24 weeks from randomization. Secondary endpoints include measures of left ventricular and atrial volumes, left ventricular mass, LVEF, and circulating cardiac biomarkers.ConclusionsEMPRESS‐MI will assess the effect of the SGLT2 inhibitor empagliflozin on cardiac remodelling in patients with left ventricular systolic dysfunction after an acute MI.
A carbon dot toolbox for managing biotic and abiotic stresses in crop production systems
Authors: Zia Muhammad U. , Sambasivam Prabhakaran Thanjavur , Chen Dechao , Bhuiyan Shamsul A. , Ford Rebecca , Li Qin 
Published: May 2024

AbstractThe productivity of global crop production is under threat caused by various biotic and abiotic adverse conditions, such as plant diseases and pests, which are responsible for 20%–40% of global crop losses estimated at a value of USD 220 billion, and can be further exacerbated by climate change. Agricultural industries are calling for game‐changer technologies to enable productive and sustainable farming. Carbon dots (C‐dots) are carbon‐based nanoparticles, smaller than 50 nm, exhibiting unique opto‐electro‐properties. They have been shown to have positive impact on managing diverse biotic and abiotic stresses faced by the crops. Owing to their versatile carbon chemistry, the surface functionalities of C‐dots can be readily tuned to regulate plant physiological processes. This review is focussed on establishing the correlations between the physiochemical properties of C‐dots and their impacts on plants growth and health. The summary of the literature demonstrates that C‐dots hold great promise in improving plant tolerance to heat, drought, toxic chemicals, and invading pathogens.image