bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparative analysis of genetic testing utilization rates among people with and without disabilities in South Korea from 2016 to 2019, focusing on malignant neoplasms: A national population‐based study
Authors: Bang Gwanwook , Park Minji , Seon Jeong‐yeon , Park So‐Youn 
Published: May 2024

AbstractIntroductionOncogene testing is widely used to detect or direct cancer treatments. Compared to people without disabilities, people with disabilities in Korea have a lower cancer incidence rate but a fivefold higher cancer mortality rate, implying delayed detection.MethodsWe used an administrative database combining disability status and care utilization to analyze every case of cancer‐related genetic testing paid for by the National Health Insurance Services of Korea between 2016 and 2019. We first compared percentages of individuals who had taken a registered genetic test by their disability statuses. We then compared the most frequently utilized tests between individuals with and without disabilities.ResultsKorean citizens, 175,000 in total, underwent at least one of the 192 registered cancer‐related genetic tests between 2016 and 2019. People with disabilities utilized these genetic tests at higher rates than those without disabilities, regardless of sex or age. Among people aged ≥40 years, lung and colorectal cancer‐related tests were most frequently utilized, regardless of disability status.ConclusionAlthough the cancer‐related genetic test uptake rate is higher among people with disabilities than among those without disabilities, it is still possible that information on these tests is not as readily available to people with disabilities. Therefore, it is imperative for the government to actively devise strategies to enhance national cancer screening rates among people with disabilities.
Love it or hate it? Deconstructing consumers' attitudes towards AI enabled voice shopping
Authors: Kamoonpuri Sana Zehra , Sengar Anita 
Published: May 2024

AbstractThe conversational, social and intelligent capabilities of Artificial Intelligence (AI) enabled voice assistants (VAs) to assist humans have grown. However, their use still remains limited for complex tasks such as shopping. While some studies find that consumers are willing to use them, others report negative reactions that lead to rejection, especially for complex activities. This study aims to bridge the gap between the dichotomous streams of literature by investigating the overall attitude towards the use of AI VAs for a multi‐step task that is, shopping. We first identify 27 attitudinal criteria through a comprehensive literature review in light of the Uncanny Valley Theory and the Self Determination Theory. The criteria are organized using the cognitive, affective and conative framework of attitude, and ranked using the Fuzzy Analytical Hierarchy Process. Sensitivity analysis is done to affirm the robustness of the framework. Findings reveal that the behavioral intentions to use (conative criteria) are the strongest, followed by feelings evoked during use (affective criteria), followed by beliefs people hold regarding AI VAs (cognitive criteria). Intention to use AI voice assistants during all stages of the purchase journey takes precedence over negative feelings such as loss of control, unfulfillment and vulnerability. This study reconciles the existing stream of literature on conversational AI and provides managerial implications based on the dimensions of attitude.
Overview of the 2023 FDA Circulatory System Devices Advisory Panel meeting on the Recor Paradise Ultrasound‐Based Renal Denervation System
Authors: Haberman Dan , Chitturi Kalyan R. , Lupu Lior , Wermers Jason P. , Waksman Ron 
Published: May 2024

AbstractHypertension continues to be a prominent, avoidable factor contributing to major vascular issues on a global scale. Even with lifestyle adjustments and more aggressive medical treatments, maintaining optimal blood pressure levels remains challenging. This challenge has driven the emergence of device‐oriented approaches to address hypertension. To assess the safety and efficacy of the Recor Paradise Ultrasound Renal Denervation System, the Circulatory System Devices Panel was convened by the US Food and Drug Administration (FDA). This manuscript provides a condensed overview of the information put forth by the sponsor and the FDA, along with an account of the considerations and conversations that took place during the meeting.
Synthesis of Diverse Allylic Sulfone Derivatives via Sequential Hydroalkoxylation of 1,3‐Enynes
Authors: Kumar Sourav , Shah Bhahwal Ali 
Published: May 2024

AbstractA first metal‐free protocol for the synthesis of allylic sulfones featuring aldehyde functionality at the δ‐position has been reported. The formation of structurally complex δ,δ‐dimethoxy allylic sulfones is enabled by the direct nucleophilic attack of methoxide onto the sulfone‐containing 1,3‐enynes. The present approach allows facile installation of acetal groups within the allylic sulfone scaffold, providing versatile platforms for further functionalization and drug development.
Heterometallic Mg‐Ni‐Mg Complex Promoted Hydrosilylation of Alkenes: Catalytic Performance and Intermediates Characterization†
Authors: Cai Yanping , Jiang Shengjie , Xu Xin 
Published: May 2024

Comprehensive SummaryHeteronuclear metal complexes have played an increasingly important role in both small molecules activation and catalytic transformation due to the potential metal‐metal synergies. In this work, we reported that the well‐defined Mg‐Ni‐Mg complex [(LMg)2Ni(C2H4)2] {L = [(DippNCMe)2CH]−, Dipp = 2,6‐iPr2C6H3} was capable of catalyzing the conversion of a diverse array of terminal alkenes to hydrosilylated products in anti‐Markovnikov fashion using PhSiH3 as the silicon source. The stoichiometric reaction of heterometallic Mg‐Ni‐Mg complex with one equivalent PhSiH3 obtained a silyl‐nickel‐monohydride complex [(LMg)2NiH(C2H4)(SiHPhEt)] featuring a Ni‐Si‐H‐Mg interaction. Moreover, treatment of heterometallic Mg‐Ni‐Mg complex with three equivalents PhSiH3 provided the silyl‐nickel‐trihydride complex [(LMg)2NiH3(SiHPhEt)] with three hydride‐bridged at Mg‐Ni‐Mg fragment. Further reactions of the resultant silyl‐nickel complexes with alkenes, e.g., ethylene and styrene, yielded the corresponding alkene‐coordinated Mg‐Ni‐Mg complexes [(LMg)2Ni(C2H4)2], [(LMg)2NiH2(C2H4)] and [(LMg)2NiH2(CH2CHPh)], respectively, with the elimination of PhEtSiH2. Based on the control experiments, both silyl‐nickel‐monohydride and silyl‐nickel‐trihydride complexes were considered as active intermediates in the catalytic hydrosilylation reaction.
De novo Synthesis of Chiral 3,4‐DihydroquinazolinesviaOne‐Pot Enantioselective Ugi‐Azide/Cyclization Sequences†
Authors: Xie Zu‐Kui , Ding Jun‐Jun , Ou Yi‐Ming , Shi Jun‐Xiu , Shen Meng‐Lan , Yao Chuan‐Zhi , Jiang Hua‐Jie , Yu Jie 
Published: May 2024

Comprehensive SummaryHerein, we reported a precise de novo synthesis of chiral 3,4‐dihydroquinazoline frameworks via a one‐pot anionic stereogenic‐at‐cobalt(III) complex‐catalyzed enantioselective Ugi‐azide/Pd‐catalyzed cyclization sequence. This powerful protocol involves 5 components and 2 catalytic systems, delivering chiral 3,4‐dihydroquinazolines with excellent enantioselectivities (up to 94% ee). The preliminary antifungal experiments suggest that both Ugi‐adducts and 3,4‐dihydroquinazolines have great potential in inhibiting plant pathogens such as Trichoderma viride and Fusarium graminearum.
Phthalazine Sulfonamide Derivatives as Carbonic Anhydrase Inhibitors. Synthesis, Biological and in silico Evaluation
Authors: Angeli Andrea , Petrou Anthi , Kartsev Viktor G. , Zubenko Alexandr , Divaeva Lyudmila N. , Chekrisheva Victoria , Iacopetta Domenico , Sinicropi Maria Stefania , Sirakanyan Samvel , Geronikaki Athina , Supuran Claudiu T. 
Published: May 2024

AbstractCarbonic Anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide involved in several biological processes. They show a wide diversity in tissue distribution and their subcellular localization. Twenty‐two novel phthalazine derivatives were designed, synthesized, and evaluated against four human isoforms: hCA I, hCA II, hCA IX, and hCA XII. Compounds appeared to be very active mostly against hCA IX (7) and hCA I (6) isoforms being more potent than reference drug acetazolamide (AAZ). Some compounds appeared to be very selective with a selectivity index up to 13.8. Furthermore, docking was performed for some of these compounds on all isoforms to understand the possible interactions with the active site. Additionally, the most active compounds against hCA IX were subjected to cell viability assay. The anticancer activity of the compounds (3 a–d, 5 d, 5 i, and 5 m) was investigated using two human breast cancer cell lines, i. e. MCF‐7 and MDA‐MB‐231 cells, and the normal counterpart, namely MCF10‐A cells.
Naphtho[1,8‐ef]isoindole‐7,8,10(9H)‐trione as Novel Theranostic Agents for Photodynamic Therapy and Multi‐Subcellular Organelles Localization
Authors: Tan Shaoying , Fu Qiqi , Lei Kecheng , Mei Wenyi , Liu Jianwen , Qian Xuhong , Xu Yufang 
Published: May 2024

AbstractA series of naphtho[1,8‐ef]isoindole‐7,8,10(9H)‐trione derivatives as novel theranostic agents for photodynamic therapy and multi‐subcellular organelles localization were designed and synthesized. Most of them possess moderate fluorescence quantum yield and long wavelength absorption simultaneously, which made them possible for dual effects of imaging and therapy. Notably, compounds 7 b and 7 d exhibited significant light‐toxicity but slight dark‐toxicity. Confocal fluorescence microscopy experiments demonstrated that compound 7 b can locate and image in special multi‐subcellular organelles. All the research results implied that naphtho[1,8‐ef] isoindole‐7,8,10(9H)‐trione derivatives can be applied as a new series of theranostic agents with the characteristics of photodynamic therapy and multi‐subcellular organelles imaging.
RCPA: An Open‐Source R Package for Data Processing, Differential Analysis, Consensus Pathway Analysis, and Visualization
Authors: Nguyen Hung , Nguyen Ha , Maghsoudi Zeynab , Tran Bang , Draghici Sorin , Nguyen Tin 
Published: May 2024

AbstractIdentifying impacted pathways is important because it provides insights into the biology underlying conditions beyond the detection of differentially expressed genes. Because of the importance of such analysis, more than 100 pathway analysis methods have been developed thus far. Despite the availability of many methods, it is challenging for biomedical researchers to learn and properly perform pathway analysis. First, the sheer number of methods makes it challenging to learn and choose the correct method for a given experiment. Second, computational methods require users to be savvy with coding syntax, and comfortable with command‐line environments, areas that are unfamiliar to most life scientists. Third, as learning tools and computational methods are typically implemented only for a few species (i.e., human and some model organisms), it is difficult to perform pathway analysis on other species that are not included in many of the current pathway analysis tools. Finally, existing pathway tools do not allow researchers to combine, compare, and contrast the results of different methods and experiments for both hypothesis testing and analysis purposes. To address these challenges, we developed an open‐source R package for Consensus Pathway Analysis (RCPA) that allows researchers to conveniently: (1) download and process data from NCBI GEO; (2) perform differential analysis using established techniques developed for both microarray and sequencing data; (3) perform both gene set enrichment, as well as topology‐based pathway analysis using different methods that seek to answer different research hypotheses; (4) combine methods and datasets to find consensus results; and (5) visualize analysis results and explore significantly impacted pathways across multiple analyses. This protocol provides many example code snippets with detailed explanations and supports the analysis of more than 1000 species, two pathway databases, three differential analysis techniques, eight pathway analysis tools, six meta‐analysis methods, and two consensus analysis techniques. The package is freely available on the CRAN repository. © 2024 The Authors. Current Protocols published by Wiley Periodicals LLC.Basic Protocol 1: Processing Affymetrix microarraysBasic Protocol 2: Processing Agilent microarraysSupport Protocol: Processing RNA sequencing (RNA‐Seq) dataBasic Protocol 3: Differential analysis of microarray data (Affymetrix and Agilent)Basic Protocol 4: Differential analysis of RNA‐Seq dataBasic Protocol 5: Gene set enrichment analysisBasic Protocol 6: Topology‐based (TB) pathway analysisBasic Protocol 7: Data integration and visualization
Cardiac resynchronization therapy in inotrope‐dependent heart failure: a meta‐analysis
Authors: Al‐Shakarchi Nader J. , Ho Jamie S.Y. , Bray Jonathan J.H. , D'Ascenzo Fabrizio , Duffy Edward , Hewett Jack , Adegbie Divine , Khan Faizullah , Kumar Niraj S. , Patel Neal , Ahmad Mahmood , Banerjee Amitava , Haq Ikram , Providencia Rui 
Published: May 2024

AbstractAimsThe viability of cardiac resynchronization therapy (CRT) in inotrope‐dependent heart failure (HF) has been a matter of debate.Methods and resultsWe searched Medline, EMBASE, Scopus, and the Cochrane Library until 31 December 2022. Studies were included if (i) HF patients required inotropic support at CRT implantation; (ii) patients were ≥18 years old; and (iii) they provided a clear definition of ‘inotrope dependence’ or ‘inability to wean’. A meta‐analysis was performed in R (Version 3.5.1). Nineteen studies comprising 386 inotrope‐dependent HF patients who received CRT (mean age 64.4 years, 76.9% male) were included. A large majority survived until discharge at 91.1% [95% confidence interval (CI): 81.2% to 97.6%], 89.3% were weaned off inotropes (95% CI: 77.6% to 97.0%), and mean discharge time post‐CRT was 7.8 days (95% CI: 3.9 to 11.7). After 1 year of follow‐up, 69.7% survived (95% CI: 58.4% to 79.8%). During follow‐up, the mean number of HF hospitalizations was reduced by 1.87 (95% CI: 1.04 to 2.70, P < 0.00001). Post‐CRT mean QRS duration was reduced by 29.0 ms (95% CI: −41.3 to 16.7, P < 0.00001), and mean left ventricular ejection fraction increased by 4.8% (95% CI: 3.1% to 6.6%, P < 0.00001). The mean New York Heart Association (NYHA) class post‐CRT was 2.7 (95% CI: 2.5 to 3.0), with a pronounced reduction of individuals in NYHA IV (risk ratio = 0.27, 95% CI: 0.18 to 0.41, P < 0.00001). On univariate analysis, there was a higher prevalence of males (85.7% vs. 40%), a history of left bundle branch block (71.4% vs. 30%), and more pronounced left ventricular end‐diastolic dilation (274.3 ± 7.2 vs. 225.9 ± 6.1 mL).ConclusionsCRT appears to be a viable option for inotrope‐dependent HF, with some of these patients seeming more likely to respond.
Inbuilt age, residence time, and inherited age from radiocarbon dates of modern fires and late Holocene deposits, Western Transverse Ranges, California
Authors: Scharer Katherine , McPhillips Devin , Leidelmeijer Jenifer , Kirby Matthew 
Published: May 2024

AbstractRadiocarbon dates from alluvial sections provide maximum deposit ages because of the time lag between formation of the dated material and deposition at the sample site, potentially producing decade‐ to century‐long biases in the dates of historic events, paleoclimatic change, fire histories, and paleoearthquakes. This bias, called the inherited age, combines the inbuilt age distribution, which reflects the age composition of the vegetation of the source area, and the residence time distribution, which includes transport and interim storage prior to final deposition. We tackle inherited age and its components by comparing charcoal dates from two modern fires in southern California, the 2020 Bobcat Fire and the 2013 Grand Fire, with a well‐dated late Holocene terrace deposit in the Pallett Creek watershed. Fifty‐six radiocarbon dates from the modern fires provide an inbuilt age distribution with a median of 25 years pre‐fire (320‐year 95% range). An inherited age distribution calculated from 175 terrace deposit dates is older, with a median age of ~90 years (850‐year 95% range). Comparing inherited ages calculated from organic‐rich versus clastic terrace deposits reveals a slight facies dependence suggesting longer residence times in clastic deposits. We develop a modeled inherited age that incorporates larger calibration uncertainties in pre‐1950s samples by combining the modern fire sample distribution with the pre‐bomb portion of the calibration curve. The modeled inherited age is younger than the terrace deposit inherited age by only 21 years, indicating inbuilt age, not long residence times, dominates inherited age in this setting. The results imply that paleoearthquakes and climatic event age estimates in the Western Transverse Ranges are up to a century too old. More broadly, dating charcoal from modern fires can constrain inherited age and the resulting distributions can improve the accuracy of dates of past environmental and tectonic events.
The hawthorn (Crataegus pinnatifida Bge.) fruit as a new dietary source of bioactive ingredients with multiple beneficial functions
Authors: Ma Jin‐Xin , Yang Wei , Ng Chester Yan Jie , Tang Xu‐Dong , Wong Sunny , Gan Ren‐You , Zhong Linda 
Published: May 2024

AbstractThe discovery of new natural sources has brought increased attention to the development of functional foods. The hawthorn (Crataegus pinnatifida Bge.) fruit is an underutilized fruit due to its benefits for human health and good taste. It contains a variety of bioactive ingredients, contributing to its multiple beneficial functions and applications. This review summarized and discussed the main bioactive ingredients, beneficial functions based on in vitro, in vivo, and human studies, and different applications of the hawthorn fruit according to the updated literature in the past 3 years. Hawthorn berries contain phenolic acids, flavonoids, proanthocyanidins, pectin, and many other bioactive components, which have a variety of beneficial functions, such as antioxidant, anti‐inflammatory, antibacterial, antidiabetic, intestinal protection, cardiovascular protection, hepatoprotection, anti‐cancer, and neuroprotection. Its potential molecular mechanism and different food‐related applications such as hawthorn wine and antioxidant drink are discussed in detail in this review. Additionally, hawthorn berries are shown to be safe when consumed within the proper dosage. Collectively, this updated review indicates that the hawthorn fruit can be a new dietary source of bioactive ingredients with multiple beneficial functions and can be affordably developed into functional and medicinal foods for the prevention and management of certain chronic diseases.
A phase 3b study of venetoclax and azacitidine or decitabine in an outpatient setting in patients with acute myeloid leukemia
Authors: Manda Sudhir , Anz Bertrand M. , Benton Christopher , Broun E. Randolph , Yimer Habte A. , Renshaw John S. , Geils George , Berdeja Jesus , Cruz Jose , Melear Jason M. , Fanning Suzanne , Fletcher Luke , Li Yukun , Duan Yinghui , Werner Michael E. , Potluri Jalaja , Pai Madhavi V. , Donnellan William B. 
Published: May 2024

AbstractVenetoclax, a highly selective BCL‐2 inhibitor, combined with hypomethylating agents (HMAs) azacitidine or decitabine, is approved for the treatment of newly diagnosed acute myeloid leukemia (ND AML) in patients who are ineligible to receive intensive chemotherapy. Previous clinical studies initiated venetoclax plus HMA in an inpatient setting owing to concerns of tumor lysis syndrome (TLS). This study (NCT03941964) evaluated the efficacy and safety of venetoclax plus HMA in a United States community–based outpatient setting in patients with ND AML (N = 60) who were treatment naïve for AML, ineligible to receive intensive chemotherapy, had no evidence of spontaneous TLS at screening, and were deemed as appropriate candidates for outpatient initiation of venetoclax plus HMA by the investigator. Patients received venetoclax in combination with azacitidine (75 mg/m2) or decitabine (20 mg/m2) for up to 6 cycles during the study. With a median time on study of 18.3 weeks, the best response rate of composite complete remission was 66.7%, and the overall post‐baseline red blood cell (RBC) and platelet transfusion independence rate was 55.0%, consistent with results of studies in which treatment was initiated in an inpatient setting. Key adverse events included nausea, anemia, thrombocytopenia, neutropenia, and white blood cell count decrease of any grade (≥50% of patients). The observed safety profile was generally consistent with that of venetoclax plus HMA observed in inpatient AML studies. With close monitoring, 2 cases of TLS were identified, appropriately managed, and the patients were able to continue study treatment.Clinical Trials RegistrationThis study is registered at ClinicalTrials.gov. The registration identification number is NCT03941964.
Exergy analysis of ejector‐enhanced dual‐evaporator cycle using effective temperature method
Authors: Anuradha Parinam 
Published: May 2024

AbstractThis study compares the exergy of an ejector‐based two evaporator cycle (EB‐TEC) with a conventional two evaporator cycle (C‐TEC). The analysis utilizes a modified Gouy–Stodola equation, which provides a more accurate insight of the system irreversibility compared to the standard Gouy–Stodola formulation. Furthermore, the comparison includes three working fluids, that is, R134a, R1234ze, and R600 in both the cycles. The study examines the effects of varying evaporators and condenser temperatures and the dryness fraction at the exit of Evaporator 1. The data is analyzed using an Engineering Equation Solver. The findings indicate that increasing the temperature of the low‐temperature evaporator leads to a drop in exergy losses and enhancement in exergy efficiency in both the cycles. When the temperature of Evaporator 1 is increased, the total exergy of the EB‐TEC is decreased but for the C‐TEC, it is increased. Furthermore, increasing the condenser temperature results in higher exergy destruction in both EB‐TEC and C‐TEC. Notably, the maximum exergy destruction is 49.44 kW for R600, whereas the minimum exergy destruction is 14.42 kW for R1234ze in the EB‐TEC.
Research progress in the development of 3D skin models and their application to in vitro skin irritation testing
Authors: Lu Hongxia , Zuo Xulei , Yuan Jiayu , Xie Zhuoying , Yin Lihong , Pu Yuepu , Chen Zaozao , Zhang Juan 
Published: May 2024

AbstractToxicological assessment of chemicals is crucial for safeguarding human health and the environment. However, traditional animal experiments are associated with ethical, technical, and predictive limitations in assessing the toxicity of chemicals to the skin. With the recent development of bioengineering and tissue engineering, three‐dimensional (3D) skin models have been commonly used as an alternative for toxicological studies. The skin consists of the subcutaneous, dermis, and epidermis. All these layers have crucial functions such as physical and biological protection and thermoregulation. The epidermis is the shallowest layer protecting against external substances and media. Because the skin is the first contact point for many substances, this organ is very significant for assessing local toxicity following skin exposure. According to the classification of the United Nations Global Harmonized System, skin irritation is a major potentially hazardous characteristic of chemicals, and this characteristic must be accurately assessed and classified for enhancing chemical safety management and preventing and reducing chemical accidents. This review discusses the research progress of 3D skin models and introduces their application in assessing chemical skin irritation.