bluuebunny/crossref_metadata_2025_split huggingface dataset:
P30 Transparent plastic foils allow a short patch‐test application time
Authors: Bjarnason Bolli , Fischer T , Elmets CA , Flosadottir E 
Published: August 2010

Objective:  To investigate whether application of allergic patch tests with transparent semi‐occlusive adhesive plastic foils yields higher test sensitivity than when tapes are used. To study whether such foils compared to tapes allow a shorter application time of tests.Methods:  We applied different doses of budesonide printed on polyester squares and vehicle control squares to budesonide allergic subjects for 4 days. Each subject was tested with a set of tests both with a tape and a foil. We assessed all tests when they had been detached and additionally those applied with foils at earlier time points. All assessments were performed both visually and with a laser Doppler perfusion imaging technique.Results:  Test sensitivity is higher with foil applications than when tapes are used and the perfusion is higher with the foils in many cases. The foils allow detachment of visually positive tests before 48 hours in some subjects, regardless of dose.Conclusions:  Test applications with transparent semi‐occlusive adhesive plastic foils is sensitive and should be considered for application of patch tests when a short application time is important as when tests are carried out with occupationally hazardous allergens or when test substances containing allergens are expected to be irritating.
P34 Reproducibility of the positive patch test reactions with the TRUE Test
Authors: Jensen Charlotte Devantier , Andersen KE 
Published: August 2010

The patch test results of patients tested at least twice at our clinic during a period of 11 years were analyzed with regard to reproducibility of the positive patch test reactions found in the first patch testing session.A retrospective analysis of 257 patients who have been tested with the TRUE Test at least twice between 1991 and 2002 and had a minimum of one positive reaction in the first testing session was done. Test reactions were read routinely after 3 and 5–7 days.In the first testing session a total of 299 positive reactions were found. Of these allergens, 151 (51%) stayed positive in the second test, 31 (10%) produced a doubtful reaction, 67 (22%) a negative response, and 50 (17%) were not retested because of strong positive reactions in the first test. Of the individual allergens, positive reactions from thiuram‐mix, kathon CG and colophony were the most reproducible.If it is assumed that allergens which were not retested because of strong positive reactions would have shown positive reactions in a retest, a total of 68% of positive reactions were reproduced. A multitude of factors, such as: avoidance of relevant allergens between tests, diminished sensitivity, retesting within a period of more or less active dermatitis, different observers, methodological error, and prior false‐positive responses, influence the reproducibility of patch tests. The results will be put in perspective.
P35 Photo‐, phyto‐ and frostbite‐ provoked cases of contact dermatitis cured with o3
Authors: Krivatkin Sergey L , Krivatkina EV 
Published: August 2010

Objectives:  To show cases of contact dermatitis (CD) provoked by different factors and possibility of their treatment with ozone application.Methods:  Description of clinical cases:Patient S., female, 17 years old, came to dermatologist with complaints on erythema and vesicles, sense of burning on the face during two weeks. The patient works on the market, exposures by sun. As a result of a talk with the patient, new perfume as a possible reason of photoallergic reaction was suspected. The patient was successfully treated by use of ozone therapy: 6 autochemotherapy minor (AHTmin) treatments were applied. By the end of the course crusts and hyperpigmentation only were observed.Patient T., male, 36 years old, suffered from erythema and vesicles, itching and sense of burning on both hands and arms for 3 days. During weekend he had contact with cow‐parsnip plant. The patient got 5 AHT minor treatments: clinical recovery was registered.Patient S., 36 years old, frosted his hands two weeks ago. When he came to dermatologist, erythema, vesicles, erosions and crusts on the backs of the hands were observed. Ozone therapy (AHTmin – 5 treatments plus ozonized water externally) was successfully applied: full recovery was registered.Summary of results:  Different cases of CD were successfully treated by ozone therapy use.Conclusions:  CD provoked by different factors can be cured with ozone.
P39 The accuracy of material safety data sheets: reporting of skin irritants and skin sensitisers
Authors: Keegel T , Saunders H , Nixon Rosemary 
Published: August 2010

Objectives:  In Australia the National Occupational Health and Safety Commission (NOHSC) requires that manufacturers provide Material Safety Data Sheets (MSDS) for all hazardous materials. However the accuracy of MSDS has not previously been assessed, utilizing the specified NOHSC criteria for hazardous substances.Methods:  100 consecutive product MSDS were collected from workers with potential work‐related cutaneous exposure, attending an occupational dermatology clinic. Manufacturers were contacted to verify the ingredients of each product. MSDS were evaluated using for skin irritants and skin sensitisers, and for compliance with the NOHSC criteria for hazardous substances (sensitisers present at a concentration >=1%, irritants present at a concentration >=20%). All sensitisers were checked for clinical significance (relevant positive patch test result) to the worker’s dermatitis.Results:  On manufacturer follow‐up, 58% of the MSDS satisfied the NOHSC criteria. However, 3 products omitted sensitisers, present at <1%. Importantly, one sensitiser was clinically significant. 19% failed to meet the NOHSC criteria. 17 MSDS omitted sensitisers at >=1%, two omitted irritants at >=1%. Irritants were specified correctly in 19/22 cases, whereas sensitisers were specified correctly in only 30/71 cases (p = 0.0003). Non‐compliant MSDS may have been as high as 42%, as insufficient information to enable assessment was provided on manufacturer follow‐up regarding the percentage concentration of 1 unlisted irritant and 22 unlisted sensitisers.Conclusion:  MSDS are significantly inaccurate with respect to skin sensitisers. Sensitisers and percentage concentration are frequently omitted from MSDS, thereby providing inadequate information for the prevention of skin sensitisation for workers.
P41 Contact allergy to clindamycin
Authors: Sinovich Vania , Powell S 
Published: August 2010

A 42‐year–old non‐atopic lady was treated with twice daily 2% clindamycin vaginal cream (Dalacin®) and ster‐zac (bath antiseptic) for hidradenitis of the groins. She also had mild facial acne.She developed genital pruritus and erythema which quickly became generalised which she related to the use of ster‐zac. However, when she applied clindamycin to her face a few weeks later, she developed a severe reaction which became generalised.The patient was patch tested with an extended European series, the clindamycin cream, ster‐zac 1:100 and E45 which had also been used. Initially she developed an angry back picture which was difficult to assess but the standard testing was negative.Repeat patch testing to the constituents of the topical preparations used produced a reaction to clindamycin 1%, 5% and to dalacin cream ‘as is’.
Discussion:
Coskey1 first described contact allergy to clindamycin in 1978. Since then there have been 6 further case reports. Mild local adverse reactions to topical clindamycin preparations such as burning, excessive dryness, itching and erythema are not uncommon, but more serious adverse events should prompt exclusion of a contact allergic component. Despite topical clindamycin being used for more than 25 years, sensitisation appears uncommon.
P45 Neomycine sulfate patch tests
Authors: Bjarnason Bolli , Flosadottir Ellen 
Published: August 2010

Objective:  The purpose of this study is to investigate if patients with neomycin sulfate allergy may develop test responses that are unclassifiable by commonly used assessment scales but which should be considered positive.Materials:  16 patients who tested positive to neomycin sulfate patch tests are retested with different dose levels and application times. Test areas are assessed visually up to 11 days.Results:  Three types of reactions were observed. The first type was characterized by erythema and diffuse infiltrate. Some of these had in addition either discrete papules or both papules and vesicles on their surface. The second type of reaction initially developed large perifollicular papules which later developed into coalescent erythema and diffuse infiltrate. The third type of reaction exhibited perifollicular papules only which declined over time. This type was unclassifiable by commonly used assessment scales. All types of reactions were of clinical significance.Conclusion:  The results support that universal assessment scales for patch‐test responses due to different test agents may be inappropriate for assessment of neomycin sulfate patch tests. The clinician should only consider assessment scales as an aid in the assessment of test responses and be aware that morphology of test responses may differ between test agents and test techniques.
P50 Occupational dermal exposure to permanent hair dyes in hairdressers
Authors: Lind Marie‐Louise , Boman A , Sollenberg J , Johnsson S , Hagelthorn G , Meding B 
Published: August 2010

Objective:  To assess occupational dermal exposure to permanent hair dyes in hairdressers.Methods:  Dermal exposure was assessed in 31 hairdressers using a previously evaluated method, hand wash sampling with bag rinsing. The measurements were performed in hairdressing saloons during working hours. Hand wash samples were collected from each hand before start of the hair dyeing process, after application of the hair dye and after cutting the newly dyed hair. 13 of the hairdressers did not use gloves during application of the hair dye, and during cutting of the dyed hair no one used gloves. The samples were analysed for aromatic amines and resorcinol using an HPLC‐method.Results:  After application of the hair dye PPD (p‐phenylenediamine) was found in samples from 1 hairdressers (148–185 nmol/hand), TDA (toluenediamine) in samples from 12 hairdressers (range 10–735 nmol/hand) and resorcinol in 22 individuals (range 19–769 nmol/hand). In the samples taken after cutting the dyed hair PPD was found in 2 hairdressers (range 36–358 nmol/hand), TDA in 14 (range 8–361 nmol/hand) and resorcinol in 20 (range 10–725 nmol/hand.Conclusion:  Skin exposure to aromatic amines and resorcinol was detected in more than half of the hairdressers after application of hair dye and also after cutting newly dyed hair. To reduce exposure improved skin protection is important.
P52 Contact dermatitis due to computer’s mouse
Authors: Fernandez‐Redondo Virginia , Suarez Amor O , Toribio J 
Published: August 2010

Background:  Introduction of informatics has facilitated the apparition of lesions affecting the hand responsible of mouse movement. Different cases of contact dermatitis related to the use of personal computers have been published in the last years and two new morphologic patterns within cutaneous pathology affecting hands have been described in direct relationship with professional occupation, named generally “computer fingers” and “computer palms”.Case report:  We present a 7‐patient series presenting lesions suggesting contact dermatitis after continued use (min 8 hours/day) of personal computer from a total of 700 patients revised. Patch tests including standard series of the GEIDC, series for plastics and glues and others related to specific details of each patient were performed in all cases. Six of our patients presented lesions in the 2, 3 and 4 fingers of the right hand while the other one was affected in the right hand palm. In our patients, all the epicutaneous tests were negative or without relevance, suggesting a mechanical cause to the occupational dermatitis presented.Comments:  Products used in the fabrication of ABS plastics, employed to make personal computers mouse, such as ftalates, cobalt salts and resorcinol monobenzoate have been described as possible allergens. However, concentration of these allergens is too small to ensure a causal relationship. Pressure or an excessive sweating could facilitate these reactions. Wide use of informatics nowadays obliges us to consider those factors in patients presenting chronic dermatoses in their hands. Furthermore, better ergonomics in work places could prevent this kind of occupational dermatitis.
P53 Hand contact dermatitis in jewellwery 2 cases
Authors: Sanchez‐Politta Sabrina , Piletta P 
Published: August 2010

The production of jewellery is currently mostly industrial and the jewellers perform only one or two stages in the manufacturing process. The jewellers make jewellery by hand in small workshops and are more polyvalent: they shape the metal with pliers or hand tools or cast it in moulds, assemble the individual parts with glues, carve metal, diamonds and other stones, clean metals with soaps and ultrasonic baths. The occupational dermatitis is of irritant nature (acid and alkalis in metal cleaners, soaps, detergents, metal dust, abrasions from polishing wheels and emery paper, heat, adhesives, etc) and allergic nature (potassium dichromate, 2‐mercaptobenzothiazole, ammoniated mercury, carba mix, epoxy resin, mercapto mix, formaldehyde, nickel, colophony). We report the cases of two jewellers working in workshops.A 47 year old atopic woman already known for a sensitivity to metals (nickel, potassium dichromate and cobalt) developed recurrent vesiculo‐pustular erythematous lesions of both palms with occasional infections treated with systemic antibiotics and topical steroids. Patch tests were performed for the European standard series, woods, and personal series. There were positive + reactions at 96 h to colophony, palladium, and personal waxes. Information obtained through the manufacturer revealed colophony in the waxes frequently used by jewellers to fix the precious stones to woods and metal allowing the stones to be carved. A 47 years old atopic man working as a jeweller for 32 years developed recurrent eczematous lesions of the fingers of the right hand. Patch tests were performed for the European standard series, preservatives, plastics, acrylates and personals series and were positive + + at 96 h for urea formaldehyde, diethylenetriamine, araldite hardener and the soap used to clean the jewels. Uncommonly this contact allergy is not due to the epoxy resins themselves but to the hardener. The urea formaldehyde and the diethylenetriamine are in fact used as epoxy resins hardeners. There were no reactions to the araldite resin but there was one to its hardener.In conclusion we report two unusual cases of hand contact dermatitis in jewellers. Because jewellers are exposed to a variety of substances, to detect the allergens the inquiry must be accurate and extensive patch testing may be required. Common allergens are compounds of uncommon substances and tools and uncommon allergens are compounds of well‐known sensitizers.
P57 Allergic contact dermatitis to compositae mix in children
Authors: Fortina Anna Belloni , Romano I , Marciani Magno F , Peserico A , Zacchello F 
Published: August 2010

Background and aim:  Recent studies have demonstrated that contact sensitization to Compositae is not uncommon in adults. However, to our knowledge, no data are available in children. Our purpose was to investigate the prevalence of contact sensitization to Compositae in a pediatric population.Methods:  434 consecutive pediatric patients (205 M; 229 F; mean age 6,7„,,b3,4 years) with suspected allergic contact dermatitis were patch tested with 30 haptens comprising Composite mix 5%(Tenacetum volgare, Arnica montana, Partenolide, Chamomilla recutitia, Achillea millefolium) at the Dermatology Unit of the Department of Pediatrics in Padua.Results:  11 patients (7 M; 4 F; mean age 5,6„,,b2,8 years) had a positive patch test reaction to Compositae mix. In all these patients dermatitis was localized on the face and/or on the hands. Most of them had more than one positive reaction. 6 were affected by atopic dermatitis, 2 had a personal history of mucosal atopy and one had both. In 8 patients (5 with atopic dermatitis, 2 with mucosal atopy) the reaction was considered clinically relevant.Conclusion: It might be useful to add Compositae mix to the pediatric screening series, when investigating dermatitis of air‐exposed areas in children with atopic diseases.
P61 EPOX 2002: concomitant sensitizations to epoxy resin components
Authors: Geier Johannes , Lessmann H , Jappe U , Hillen U , Uter W , Schnuch A 
Published: August 2010

Objective:  The study EPOX 2002 is performed to detect the most frequent allergens in epoxy resin systems (ES) currently in use. In particular, concomitant test reactions are analysed to identify possible ‘indicator’ allergens for a future ES test series.Methods:  Multicenter study within the German Contact Dermatitis Research Group (DKG) and the Information Network of Departments of Dermatology (IVDK) with 27 ES components.Results:  From Oct. 2002 to Nov. 2003, 120 patients have been tested with the preliminary ES series. Of the 49 patients reacting to epoxy resin based on diglycidylether of bisphenol F (DGEBF), 44 also reacted to the standard epoxy resin based on diglycidylether of bisphenol A (DGEBA), i.e., 90%(95%‐CI [confidence interval]: 78%‐97%).Out of 21 patients positive to 1,4‐butanediol diglycidylether (BDDGE), 18 also reacted to 1,6‐hexanediol diglycidylether (HDDGE)(86%; 95%‐CI: 64%‐97%). All 8 patients with allergic reaction to cresyl glycidylether (CGE) also reacted to phenyl glycidylether (PGE). Concomitant reactions to PGE and p‐tert butylphenyl glycidylether (PTBPGE) occured in 9 patients, while 5 patients reacted to PGE without reaction to PTBPGE and 6 patients vice versa.Conclusions:  Immunological cross sensitization as well as frequent concomitant exposure to DGEBA and DGEBF epoxy resins is well known. Our data support testing a DGEBA resin as an indicator. HDDGE might serve as an indicator allergen for BDDGE; however, the sample size is too small yet to make a final decision. PGE obviously is a valuable tool to detect sensitization to CGE, but not to PTBPGE.
P64 Shoe contact dermatitis
Authors: Pereira Ofélia , Araújo A , Ribeira S , Rozeira J 
Published: August 2010

Because of its numerous etiologies, foot dermatitis can be difficult to diagnose despite of thorough history and physical examination. The differential diagnoses are challenging and include allergic contact dermatitis, dyshidrosis, juvenile plantar dermatosis, atopic dermatitis, lichen planus.Methods:  In the Cutaneous Allergology Unit of the Department of Dermatovenereology of Pedro Hispano Hospital, between 1999 and 2003, 804 patients were observed with suspicion of contact dermatitis. In 9,3% there was a history of recurrent foot dermatitis. All these patients were patch tested with GPEDC standard and shoe series and shoe fragments.Results:  Twenty‐five patients revealed shoe contact dermatitis with positive reactions to the series tested, with an average age of 40 years. The dermatitis involved the dorsal aspect of the foot in 20 patients and the volar aspect in 8, the lateral aspects in 4, typically sparing the instep and flexural creases of the toes. The most common allergen were para‐tertiary‐butylphenol formaldehyde resin – PTBFR (12 patients‐48%), mercapto mix (7 patients‐28%), potassium dichromate (24%), mercaptobenzothiazole (24%).Conclusions:  The most common causes of shoe contact dermatitis were glues, followed by rubber components and chromated leather. As in other studies the most common allergen in shoe dermatitis in Portugal is PTBFR in neoprene adhesives. Rubber components (accelerators) were the second more frequent allergen in this study, probably a direct result of improved fixation of chrome and a change in footwear style and chrome sensitivity explains leather allergy. Other causes of foot contact dermatitis are iatrogenic complication, clothing (socks), cosmetics, adhesive tape and professional etiology.
P66 Occupational contact dermatitis from glues
Authors: Hillen Uwe , Geier J 
Published: August 2010

Objective:  Exposure to adhesives and glues is common in occupation. We here analyse the data of patients with suspected contact dermatitis (CD) from glues recorded within the Information Network of Departments of Dermatology (IVDK).Methods:  Data recorded between 1996 and 2001 within the IVDK were searched for patients who underwent patch testing because of suspected contact dermatitis from glues.Results:  Overall data of 829 patients were found, among them 336 with occupational skin disease. Allergic CD was diagnosed in 171/336 patients (50.9%), irritant CD in 24.7%. CD was mostly localized on the hands (72.6%), followed by the face (13.4%) and arms (3.9%). By far the most common cause of an allergic patch‐test reaction was epoxy resin (EP): 18.2%(age‐ and sex‐standardized proportion of sensitization) reacted to the standard EP based on diglycidylether of bisphenol A. reactive diluents and hardeners which elicited a positive patch‐test reaction in > 5% of the patients were phenyl glycidylether and 4,4′diamino diphenylmethane respectively. Cresyl glycidylether was positive in 4.9%. (Meth‐)acrylates which showed an allergic patch‐test reaction in >= 5% of the patients were 2‐hydroxypropyl methacrylate, hydroxyethyl acrylate, 2‐hydroxyethyl methacrylate, ethyleneglycol dimethacrylate, BIS GMA and triethyleneglycol dimethacrylate. Colophony was positive in 8.3% and p‐tert‐butylphenol formaldehyde resin in 4.1% of the patients respectively.Conclusion:  In our collective allergic CD was nearly 2‐fold more frequent than irritant CD in patients with occupational CD from glues, epoxy resin components being the most important allergens.
P68 Atopy and contact sensitisation: relationship reassessed
Authors: Spiewak Radoslaw 
Published: August 2010

Background:  Throughout medical literature, there are conflicting data on the relationship between atopy and contact sensitisation. Some authors believe that atopy is a protective factor against contact allergy, whereas others say it is a risk factor. Facing this contradiction, this study was undertaken to reassess the possible relationship.Study design:  In 5 vocational schools, 1 randomly selected class in each was invited to participate. Altogether 135 students were tested, 73 females and 62 males aged 18–19 years. As markers of atopy, positive skin prick tests, Phadiatop and elevated total IgE (>120 kU/l) were selected. Patch tests were used for the detection of contact sensitivity. Skin tests included 10 contact allergens and 16 aeroallergens relevant for this population. The tests were carried out and scored according to the ICDRG and EAACI guidelines. Statistical analysis of the relationships included Fisher’s chi‐square test and odds ratios.Results:  Positive patch tests (at least 1+ reaction) were found in 28.1% of the study subjects, positive prick test (wheal diameter at least 3 mm) in 23.7%, positive Phadiatop in 20.0%, and elevated total IgE in 23.7%. No statistically significant relationship between atopy markers and patch test results could be found. For each analysed feature, odds ratios remained close to the value of 1. As a “positive control” for the study design, the known relationship between female gender and positive patch test could be reconfirmed (for nickel: p = 0.003, OR = 12.0, 95%CI: 2.7–54.1).Conclusion:  In general population, there is no (or little) correlation between atopy and contact sensitisation.