bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dynamic facility layout problem under uncertainty: a Pareto-optimality based multi-objective evolutionary approach
Authors: Ripon Kazi , Glette Kyrre , Hovin Mats , Torresen Jim 
Published: November 2011

Abstract
In this paper, we investigate an evolutionary approach to solve the multi-objective dynamic facility layout problem (FLP) under uncertainty that presents the layout as a set of Pareto-optimal solutions. Research examining the dynamic FLP usually assumes that data for each time period are deterministic and known with certainty. However, production uncertainty is one of the most challenging aspects in today’s manufacturing environments. Researchers have only recently modeled FLPs with uncertainty. Unfortunately, most solution methodologies developed to date for both static and dynamic FLPs under uncertainty focus on optimizing just a single objective. To the best of our knowledge, the use of Pareto-optimality in multi-objective dynamic FLPs under uncertainty has not yet been studied. In addition, the approach proposed in this paper is tested using a backward pass heuristic to determine its effectiveness in optimizing multiple objectives. Results show that our approach is an efficient evolutionary dynamic FLP approach to optimize multiple objectives simultaneously under uncertainty.
Rituximab Maintenance Therapy for Granulomatosis with Polyangiitis and Microscopic Polyangiitis
Authors: ROUBAUD-BAUDRON CLAIRE , PAGNOUX CHRISTIAN , MÉAUX-RUAULT NADINE , GRASLAND ANNE , ZOULIM ABDELKADER , LE GUEN JULIEN , PRUD’HOMME ANNE , BIENVENU BORIS , de MENTHON MATHILDE , CAMPS SANDRA , LE GUERN VÉRONIQUE , AOUBA ACHILLE , COHEN PASCAL , MOUTHON LUC , GUILLEVIN LOÏC ,   the French Vasculitis Study Group
Published: November 2011

Objective.To evaluate the efficacy compared to the relapse risk and tolerance of systematic rituximab (RTX) infusions as maintenance therapy for patients with granulomatosis with polyangiitis (GPA) or microscopic polyangiitis (MPA), who entered remission taking conventional immunosuppressants or RTX.Methods.A retrospective study of the main clinical characteristics, outcomes, and RTX tolerance of patients who had received ≥ 2 RTX maintenance infusions in our center, regardless of induction regimen, between 2003 and 2010.Results.We identified 28 patients [4 MPA and 24 GPA; median age 55.5 yrs (range 18–78); 17 (60%) males] who received a median of 4 (range 2–10) RTX maintenance infusions, with median followup of 38 months (range 21–97) since diagnosis or last flare. None experienced a RTX infusion-related adverse event; 15 patients (among the 21 with available data) had hypogammaglobulinemia (predominantly IgM) prior to their last RTX maintenance infusion; 3 had infectious events (1 cutaneous abscess, 1 otitis, 1 fatal H1N1 flu). Two patients suffered pulmonary relapses shortly before a planned RTX maintenance infusion (both had increased antineutrophil cytoplasmic antibody levels and 1 had CD19+ lymphocyte reconstitution).Conclusion.Rituximab maintenance therapy was well tolerated but did not completely prevent relapses and persistent “grumbling” disease. These preliminary results remain to be confirmed by a randomized controlled trial currently in progress.
Civamide Cream 0.075% in Patients with Osteoarthritis of the Knee: A 12-Week Randomized Controlled Clinical Trial with a Longterm Extension
Authors: SCHNITZER THOMAS J. , PELLETIER JEAN-PIERRE , HASELWOOD DOUG M. , ELLISON WILLIAM T. , ERVIN JOHN E. , GORDON RICHARD D. , LISSE JEFFREY R. , ARCHAMBAULT W. TAD , SAMPSON ALLAN R. , FEZATTE HEIDI B. , PHILLIPS SCOTT B. , BERNSTEIN JOEL E. 
Published: November 2011

Objective.To evaluate the safety and efficacy of civamide cream 0.075% for the treatment of osteoarthritis (OA) of the knee.Methods.We conducted a 12-week, multicenter, randomized, double-blind study with a 52-week open-label extension. Patients with OA of the knee received either civamide cream 0.075% or a lower dose of civamide cream, 0.01%, as the control. The 3 co-primary endpoints in the double-blind study were the time-weighted average (TWA) of change from baseline to Day 84 in the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) pain subscale, the WOMAC physical function subscale, and the Subject Global Evaluation (SGE). In the 52-week open-label extension study, the Osteoarthritis Pain Score and SGE were assessed.Results.A total of 695 patients were randomized to receive civamide cream 0.075% (n = 351) or civamide cream 0.01% (control; n = 344) in the double-blind study. Significance in favor of civamide cream 0.075% was achieved for the TWA for all 3 co-primary efficacy variables: WOMAC pain (p = 0.009), WOMAC physical function (p < 0.001), and SGE (p = 0.008); and at Day 84 for these 3 variables (p = 0.013, p < 0.001, and p = 0.049, respectively). These analyses accounted for significant baseline-by-treatment interactions. In the 52-week open-label extension, efficacy was maintained. Civamide cream 0.075% was well tolerated throughout the studies.Conclusion.These studies demonstrate the efficacy of civamide cream for up to 1 year of continuous use. Civamide cream, with its lack of systemic absorption, does not have the potential for serious systemic toxicity, in contrast to several other OA treatments.
Frequency of Class III and IV Nephritis in Systemic Lupus Erythematosus Without Clinical Renal Involvement: An Analysis of Predictive Measures
Authors: WAKASUGI DAISUKE , GONO TAKAHISA , KAWAGUCHI YASUSHI , HARA MASAKO , KOSEKI YUMI , KATSUMATA YASUHIRO , HANAOKA MASANORI , YAMANAKA HISASHI 
Published: November 2011

Objective.To determine the frequency of International Society of Nephrology/Renal Pathology Society (ISN/RPS) class III or IV lupus nephritis in patients with systemic lupus erythematosus (SLE) without clinical renal involvement.Methods.We investigated the renal pathology of 195 patients with SLE, including 86 patients without clinical renal involvement.Results.Lupus nephritis other than class I was found in 58% of the patients without clinical renal involvement, and class III and IV nephritis was found in 15% of these patients. To reveal the predictive measures involved in class III or IV lupus nephritis, we explored the clinical measures in patients with SLE who did not have clinical renal involvement. Anti-dsDNA antibody titers were significantly higher (p = 0.0266) and C3 values were significantly lower (p = 0.0073) in patients with class III or IV lupus nephritis than in patients without class III or IV lupus nephritis. The sensitivity and specificity values were 77% and 73%, respectively, for cutoff levels of both 40 IU/ml for anti-dsDNA antibodies and 55 mg/dl for C3 (OR 8.8, p = 0.0011).Conclusion.The frequency of nephritis, including ISN/RPS class III and IV, was unexpectedly high in SLE patients without clinical renal involvement. ISN/RPS class III or IV lupus nephritis could be hidden in patients with SLE who present both a high titer of anti-dsDNA antibody and a low concentration of C3, even when they have clinically normal urinary findings and renal function.
Clinical Significance of Cryofibrinogenemia: Possible Pathophysiological Link with Raynaud’s Phenomenon
Authors: SOYFOO MUHAMMAD S. , GOUBELLA AHMED , COGAN ELIE , WAUTRECHT JEAN-CLAUDE , OCMANT ANNICK , STORDEUR PATRICK 
Published: November 2011

Objective.To describe the clinical findings and prevalence of patients with cryofibrinogenemia (CF) and to determine whether CF is associated with primary Raynaud’s phenomenon.Methods.Between June 2006 and December 2009, 227 patients were tested for CF in a single university hospital. Forty-five patients with primary Raynaud’s phenomenon were tested for CF.Results.A total of 117 patients with CF without cryoglobulinemia were included. The main clinical manifestations included skin manifestations (50%) and arthralgia (35%). There were 67 patients with primary CF and 50 patients with secondary CF. There was no significant difference in the mean concentration of the cryoprecipitate in primary CF as compared to the secondary form (172 ± 18.6 vs 192 ± 20.9 mg/dl, respectively; p = 0.41). Highest concentrations of cryoprecipitate were observed in those containing fibrinogen only as compared to cryoprecipitates containing fibrinogen and fibronectin (301 ± 43.5 vs 125 ± 10.6 mg/dl; p < 0.001). Patients having skin necrosis (n = 3) had significantly higher values of cryofibrinogen compared to those without necrosis (638 ± 105 vs 160 ± 10.2 mg/dl; p = 0.0046). Among the 45 patients with primary Raynaud’s phenomenon, 36 had associated CF. There was no significant difference in the mean concentration of the cryoprecipitate in these patients compared to those with primary CF.Conclusion.There seems to be a significant correlation between cryofibrinogen concentration and the severity of the clinical signs, particularly when cryoprecipitate is composed of fibrinogen alone. CF might have a possible pathophysiological role in primary Raynaud’s phenomenon.
Image du corps chez l'adolescent obèse et transmission transgénérationnelle
Authors: Sanahuja Maria de la Almudena , Cuynet Patrice 
Published: November 2011

Résumé « Image du corps chez l’adolescent obèse et transmission transgénérationnelle. » À travers le cas clinique d’une adolescente obèse, les auteurs soutiennent que l’image du corps individuel révèle une fonction de contenance pour donner une figuration de la structure dynamique du groupe familial. La dimension transgénérationnelle serait un des vecteurs originels des conduites addictives utilisant le corps comme premier objet formel. En se servant de son enveloppe corporelle, le sujet réalise une tentative ultime de formaliser une représentation impensable liée à la généalogie du corps familial.
RESOURCE RECOVERY AND MATERIALS FLOW IN THE CITY
Authors: Lehmann Dr. Steffen 
Published: November 2011

Beyond energy efficiency, there are now urgent challenges around the supply of resources, materials, food and water. After debating energy-efficiency for the last decade, the focus has shifted to include resource and material-efficiency. In this context, urban farming has emerged as a valid urban design strategy in Europe, where food is produced and consumed locally within city boundaries, turning disused sites into productive urban landscapes and community gardens. Agricultural activities allow for effective composting of organic waste, returning nutrients to the soil and improving biodiversity in the urban environment. Urban farming will help to feed the 9 billion by 2050 (predicted population growth, UN-Habitat forecast 2009). This paper reports on best practice of urban design principles in regard to materials flow, material recovery, adaptive re-use of building elements and components (‘design for disassembly’; prefabrication of modular building components), and other relevant strategies to implement zero waste by avoiding waste creation, reducing harmful consumption and changing behaviour. The paper touches on two important issues in regard to the rapid depletion of the world's natural resources: the construction sector and the education of architects and designers. The construction sector: Prefabricated multi-story timber buildings for inner-city living can set new benchmarks for minimizing construction wastage and for sustainable on-site assembly. Today, the construction and demolition (C&D) sector is one of the main producers of waste; it does not engage enough with waste minimization, waste avoidance and recycling. Education and research: It's still unclear how best to introduce a holistic understanding of these challenges and to better teach practical and affordable solutions to architects, urban designers, industrial designers, and so on. One of the findings of this paper is that embedding ‘zero-waste’ requires strong industry leadership, new policies and effective education curricula, as well as raising awareness (education) and refocusing research agendas to bring about attitudinal change and the reduction of wasteful consumption.
Dispensing of rheologically complex fluids: The map of misery
Authors: Clasen Christian , Phillips Paul M. , Palangetic Ljiljana , Vermant and Jan 
Published: November 2011

AbstractRheological effects may complicate the dispensing of complex fluids, when compared to their Newtonian counterparts. In this work, fluids with tailored rheological properties have been studied using high‐speed video‐microscopy. The level of viscosity, the degree of shear thinning, and the elasticity have been varied independently. At low‐flow rates, droplets are formed that pinch off. The drop volumes, breakup mechanisms, and times have been identified. At higher‐flow rates, a continuous jet is observed, with the transition depending on the rheology of the dispensed fluid. The relevant nondimensional groups are the Ohnesorge, Deborah, and elasto‐capillary number, for when viscosity, inertia, or elastic forces dominate flow. In each of these cases, the transition between dripping and jetting dispensing occurs, controlled by a critical Weber, capillary, and Weissenberg number, respectively. This set of six nondimensional groups can be used to construct an operating space and map out areas of potential problems. © 2011 American Institute of Chemical Engineers AIChE J, 58: 3242–3255, 2012
Shadow enhancers: Frequently asked questions about distributed cis‐regulatory information and enhancer redundancy
Authors: Barolo Scott 
Published: November 2011

AbstractThis paper, in the form of a frequently asked questions page (FAQ), addresses outstanding questions about “shadow enhancers”, quasi‐redundant cis‐regulatory elements, and their proposed roles in transcriptional control. Questions include: What exactly are shadow enhancers? How many genes have shadow/redundant/distributed enhancers? How redundant are these elements? What is the function of distributed enhancers? How modular are enhancers? Is it useful to study a single enhancer in isolation? In addition, a revised definition of “shadow enhancers” is proposed, and possible mechanisms of shadow enhancer function and evolution are discussed.
A mechanistic study on the effect of dexamethasone in moderating cell death in Chinese Hamster Ovary cell cultures
Authors: Jing Ying , Qian Yueming , Ghandi Mahmoud , He Aiqing , Borys Michael C. , Pan Shih‐Hsie , Li Zheng Jian 
Published: November 2011

AbstractDexamethasone (DEX) was previously shown (Jing et al., Biotechnol Bioeng. 2010;107:488‐496) to play a dual role in increasing sialylation of recombinant glycoproteins produced by Chinese Hamster Ovary (CHO) cells. DEX addition increased sialic acid levels of a recombinant fusion protein through increased expression of α2,3‐sialyltransferase and β1,4‐galactosyltransferase, but also decreased the sialidase‐mediated, extracellular degradation of sialic acid through slowing cell death at the end of the culture period. This study examines the underlying mechanism for this cytoprotective action by studying the transcriptional response of the CHO cell genome upon DEX treatment using DNA microarrays and gene ontology term analysis. Many of those genes showing a significant transcriptional response were associated with the regulation of programmed cell death. The gene with the highest change in expression level, as validated by Quantitative PCR assays with TaqMan® probes and confirmed by Western Blot analysis, was the antiapoptotic gene Tsc22d3, also referred to as GILZ (glucocorticoid‐induced leucine zipper). The pathway by which DEX suppressed cell death towards the end of the culture period was also confirmed by showing involvement of glucocorticoid receptors and GILZ through studies using the glucocorticoid antagonist mifepristone (RU‐486). These findings advance the understanding of the mechanism by which DEX suppresses cell death in CHO cells and provide a rationale for the application of glucocorticoids in CHO cell culture processes. © 2011 American Institute of Chemical Engineers Biotechnol. Prog., 2012
Intein‐Mediated Construction of a Library of Fluorescent Rab GTPase Probes
Authors: Wu Yao‐Wen , Goody Roger S. , Alexandrov Kirill 
Published: November 2011

AbstractRab GTPases play a key role in the regulation of membrane trafficking. Post‐translational geranylgeranylation is critical for their biological activity and is conferred by Rab geranylgeranyl transferease (RabGGTase), together with an accessory factor, Rab escort protein (REP). Mechanistic studies of Rab prenylation and identification of RabGGTase inhibitors require sensitive reporters of Rab prenylation. In the present work, a combination of protein engineering and expressed protein ligation was used to construct a library of semisynthetic Rab7 fluorescent conjugates. In order to avoid synthesis of a large number of fluorescently labeled peptides, we developed a strategy that combined thiol‐reactive dye‐labeling of cysteine with in vitro protein ligation. Application of this strategy required optimization of labeling and ligation conditions to promote thiol labeling and disfavor intramolecular cyclization. Using this approach, we constructed 46 fluorescent sensors with different spectral properties that reported on the interaction of Rab7 with RabGGTase, REP‐1, and the overall prenylation reaction. Two constructs, Rab7Δ3CCK(NBD) and Rab7Δ2SCCC–dans, displayed 2.5‐ and 1.5‐fold increase in fluorescence, respectively, upon prenylation. Moreover, dansyl‐, NBD (4‐nitro‐benzofurazan)‐, I‐BA‐, and I‐SO‐labeled Rab7 conjugates exhibited two‐ to tenfold change in fluorescence upon binding to REP or RabGGTase. These fluorescent sensors allowed us to monitor Rab prenylation in real time and to investigate the assembly of Rab–REP binary and Rab–REP–RabGGTase ternary complexes.
Evolving applications of zeolite molecular sieves
Authors: Lin Christopher C. H. , Dambrowitz K. Amy , Kuznicki Steven M. 
Published: November 2011

AbstractZeolite molecular sieves are essential to many processes in adsorption, catalysis and ion exchange. From the separation of air, to petroleum cracking, to water softening and decontamination, these materials influence our everyday lives. Some researchers have come to believe that all the great discoveries in the field of molecular sieves may be in the past. Nothing could be farther from the truth. From new mechanisms for pore size control, to new nanocomposite materials, to approaching the dream of robust, industrial‐scale sieving membranes, to whole new definitions for molecular sieves, new forms and uses of these materials are rapidly evolving. © 2011 Canadian Society for Chemical Engineering
Conjugated linoleic acid formation by hydrogenation/isomerisation of safflower oil over bifunctional structured catalyst Rh/SBA‐15
Authors: Chorfa Nasima , Hamoudi Safia , Arul Joseph , Belkacemi Khaled 
Published: November 2011

AbstractDirected isomerisation of safflower oil under very low hydrogen partial pressure of 7 psi over a novel bifunctional highly structured rhodium‐based catalyst (Rh/SBA‐15), having narrow pore size distribution ranging from 4 to 8 nm, and BET‐specific surface of ≈1,000 m2 g−1, was investigated as a new chemocatalytic approach for vegetable oil hardening and simultaneously producing health‐beneficial conjugated linoleic acids (CLA). Time course profiles of (cis‐9, trans‐11)‐; (cis‐10, trans‐12)‐; (trans‐10, cis‐12)‐; (cis,cis)‐ and (trans, trans)‐octadecadienoic isomers (CLAs) as well as the other fatty acids traditionally encountered during the hydrogenation of vegetable oils are presented and discussed under selected process conditions. Preliminary results show that it is possible to tailor characteristics of the hydrogenation catalyst in such way to confer its bi‐functional activity: hydrogenation and conjugation isomerisation. © 2011 Canadian Society for Chemical Engineering
Phase 2 trial of irinotecan and thalidomide in adults with recurrent anaplastic glioma
Authors: Giglio Pierre , Dhamne Megha , Hess Kenneth R. , Gilbert Mark R. , Groves Morris D. , Levin Victor A. , Kang Sanghee L. , Ictech Sandra E. , Liu Vivien , Colman Howard , Conrad Charles A. , Loghin Monica , de Groot John , Yung W. K. Alfred , Puduvalli Vinay K. 
Published: November 2011

AbstractBACKGROUND:Therapeutic options for patients with anaplastic gliomas (AGs) are limited despite better insights into glioma biology. The authors previously reported improved outcome in patients with recurrent glioblastoma treated with thalidomide and irinotecan compared with historical controls. Here, results of the AG arm of the study are reported, using this drug combination.METHODS:Adults with recurrent AG previously treated with radiation therapy, with Karnofsky performance score ≥70, adequate organ function and not on enzyme‐inducing anticonvulsants were enrolled. Treatment was in 6‐week cycles with irinotecan at 125 mg/m2 weekly for 4 weeks followed by 2 weeks off, and thalidomide at 100 mg daily increased to 400 mg/day as tolerated. The primary endpoint was progression‐free survival rate at 6 months (PFS‐6), and the secondary endpoints were overall survival (OS) and response rate (RR).RESULTS:In 39 eligible patients, PFS‐6 for the intent‐to‐treat population was 36% (95% confidence interval [CI] = 21%, 53%), median PFS was 13 weeks (95% CI = 6%, 28%) and RR was 10%(95% CI = 3%, 24%). Radiological findings included 2 complete and 2 partial responses and 17 stable disease. Median OS from study registration was 62 weeks, (95% CI = 51, 144). Treatment‐related toxicities (grade 3 or higher) included neutropenia, diarrhea, nausea, and fatigue; 6 patients experienced venous thromboembolism. Four deaths were attributable to treatment‐related toxicities: 1 from pulmonary embolism, 2 from colitis, and 1 from urosepsis.CONCLUSIONS:The combination of thalidomide and irinotecan did not achieve sufficient efficacy to warrant further investigation against AG, although a subset of patients experienced prolonged PFS/OS. A trial of the more potent thalidomide analogue, lenalidomide, in combination with irinotecan against AG is currently ongoing. Cancer 2012;3599–3606. © 2011 American Cancer Society.
Influence of Chemical and Structural Properties of Functionalized Polythiophene‐Based Layers on Electrochemical Sensing of Atrazine
Authors: Lattach Youssef , Garnier Francis , Remita Samy 
Published: November 2011

AbstractSensitive layers based on conducting homopolymer [poly(3,4‐ethylenedioxythiophene), denoted PEDOT] and copolymers [molecularly imprinted and non‐imprinted poly(EDOT‐co‐3‐thiophene acetic acid), denoted MICP and NICP, respectively] are electrosynthesized on gold substrates and used for the electrochemical detection of atrazine. These layers are characterized by cyclic voltammetry, ATR‐FTIR spectroscopy, optical profilemetry, and AFM microscopy in order to study the effect of the chemical functionalities and of the structural properties of these conducting polymers on the physical chemistry of the interaction with atrazine targets and with the aim to improve the sensitivity of the recognition process. In particular, due to the presence in their backbones of preshaped functionalized cavities which keep the molecular memory of the targets, MICP layers show remarkable sensitivity, a low detection limit (10−9 mol L−1), and a large linear range of detection (10−8 to 10−4 mol L−1), as demonstrated by square‐wave voltammetry.