bluuebunny/crossref_metadata_2025_split huggingface dataset:
Kinesin Facilitates Phenotypic Targeting of Therapeutic Resistance in Advanced Prostate Cancer
Authors: Archer Maddison , Begemann Diane , Gonzalez-Kozlova Edgar , Nepali Prerna R. , Labanca Estefania , Shepherd Peter , Dogra Navneet , Navone Nora , Kyprianou Natasha 
Published: April 2024

Abstract
Understanding the mechanisms underlying resistance is critical to improving therapeutic outcomes in patients with metastatic castration–resistant prostate cancer. Previous work showed that dynamic interconversions between epithelial–mesenchymal transition to mesenchymal–epithelial transition defines the phenotypic landscape of prostate tumors, as a potential driver of the emergence of therapeutic resistance. In this study, we use in vitro and in vivo preclinical MDA PCa patient-derived xenograft models of resistant human prostate cancer to determine molecular mechanisms of cross-resistance between antiandrogen therapy and taxane chemotherapy, underlying the therapeutically resistant phenotype. Transcriptomic profiling revealed that resistant and sensitive prostate cancer C4-2B cells have a unique differential gene signature response to cabazitaxel. Gene pathway analysis showed that sensitive cells exhibit an increase in DNA damage, while resistant cells express genes associated with protein regulation in response to cabazitaxel. The patient-derived xenograft model specimens are from patients who have metastatic lethal castration–resistant prostate cancer, treated with androgen deprivation therapy, antiandrogens, and chemotherapy including second-line taxane chemotherapy, cabazitaxel. Immunohistochemistry revealed high expression of E-cadherin and low expression of vimentin resulting in redifferentiation toward an epithelial phenotype. Furthermore, the mitotic kinesin-related protein involved in microtubule binding and the SLCO1B3 transporter (implicated in cabazitaxel intracellular transport) are associated with resistance in these prostate tumors. Combinational targeting of kinesins (ispinesib) with cabazitaxel was more effective than single monotherapies in inducing cell death in resistant prostate tumors.
Implications: Our findings are of translational significance in identifying kinesin as a novel target of cross-resistance toward enhancing therapeutic vulnerability and improved clinical outcomes in patients with advanced prostate cancer.
Mullā Ḳābıż & the Question of Prophetic Superiority
Authors: Taj Noah Hasan 
Published: April 2024

Abstract
Ibn Kamāl Pāshā (d. 940/1534) played a key role in defending key doctrinal positions in his capacity as Ottoman Shaykh al-Islām, the most famous of which is undoubtedly his refutation of Mullā Qābiḍ (d. 933/1527). Qābiḍ (tr. Kabız), whose credentials are as unknown as Ibn Kamāl’s are known, is said to have propagated the superiority of Jesus over Muhammad, an obscure notion rarely found in the intellectual history of Islam. His ideas were eventually brought to the attention of scholarly circles, leading to him being tried before the Imperial Council by Caliph Suleymān I (d. 973/1566). Noting the inability of some scholars to defend the orthodox position regarding the superiority of Muhammad, Suleymān I called upon Ibn Kamāl to provide a robust defence on behalf of the Empire. Although unable to respond to Ibn Kamāl’s reasoning, Qābiḍ nevertheless maintained his position and thus sealed his fate for good. Only a handful of studies have been carried out on Qābiḍ. This article intends to contribute to the discussion he and his trial have sparked by translating a key epistle written by Ibn Kamāl after the trial and entitled: Risāla fī ʾAfḍaliyyat Muḥammad. Knowing that the details of the controversy between him and Mullā Qābiḍ escape us, this treatise by Ibn Kamāl gives an insight into his thinking on prophetology and his implementation of scriptural, canonical and exegetical sources. It also provides a convenient overview of the exchange he probably had with Qābiḍ.
“The Scripture Is an Instantiation of Divine Discourse”
Authors: Lindstedt Ilkka 
Published: April 2024

Abstract
Modern scholarly literature often presents classical Islamic theology treating the speech of God (kalām Allāh) and the Koran as synonyms. Moreover, the discussion on the nature of the Koran/God’s speech is portrayed as having to do with the question of whether or not the Koran was created. However, I suggest that this was only a fraction of the issues debated. Classical and post-classical Muslim scholars put forward multifaceted and sophisticated theories on the natures of divine discourse and the Koran. Many, if not most, deemed the speech of God and the Koran to be separate concepts. This article analyses the Safavid-era Iranian philosopher and theologian Mullā Ṣadrā (d. c.1045/1635) with regard to his views on the ontological and theological status of divine speech and the scripture(s), with particular emphasis on his magnum opus the Four Journeys. I trace some of Mullā Ṣadrā’s sources regarding this issue and endeavor to pinpoint the original ideas he is putting forward.
Anomalous Characteristics of Water Vapor Budget on the Tibetan Plateau under the Influence of Tropical Cyclones over the Bay of Bengal during Early Summer
Authors: Liu Beiyao , Li Ying , Wu Zhehong , Lin Jialu 
Published: April 2024

Abstract
Early summer is a peak time for tropical cyclone (TC) activities over the Bay of Bengal (BoB) and a period of South Asian monsoon onset, and the TCs during this time have a significant impact on the water vapor transport associated with monsoons. This study investigates the anomalous characteristics of the dynamic–thermal atmospheric circulation structure and water vapor budget over the Tibetan Plateau (TP) under the influence of BoB TCs generated in May from 1979 to 2020 with JTWC best track data and ERA5 data. Results reveal that a significant southerly water vapor channel forms from the BoB to the southeastern TP with a water vapor convergence near the Yarlung Zangbo Grand Canyon. A part of the water vapor is transported directly to the TP by deep southerly jet, while the other part is lifted by TCs and then climbs upward to the TP by two uplift processes occurring on the southern slope of the TP and over the TP respectively, which makes the whole troposphere over the southeastern TP warmer and wetter. It is found that anomalous southeasterly airflow in the northeast of TC circulation turns to anomalous southwesterly airflow forming an abnormal anticyclonic circulation over the southern TP in the middle and upper troposphere due to the diabatic heating effect. In this process, the TP acts as an anomalous water vapor sink with remarkable water vapor inflow through its southern boundary, with the main water vapor outflow through the eastern boundary, but a weak easterly water vapor backflow to the eastern TP in the lower troposphere.

Significance Statement
This study attempts to investigate the anomalous features of the water vapor budget over the Tibetan Plateau (TP) under the influence of the Bay of Bengal (BoB) tropical cyclones (TCs) during early summer. Results show that a significant southerly water vapor channel forms from the BoB to the southeastern TP with a water vapor convergence near the Yarlung Zangbo Grand Canyon. The TP acts as an anomalous water vapor sink with more and higher water vapor inflows through the southern boundary of the TP. A positive temperature and humidity anomaly can be found over the southeastern TP extending upward into the middle and upper troposphere. The results are helpful to understand how the BoB TCs affect the weather process over the TP.
Assessment of recent UK fire safety guidance for covered car parks and electric vehicles
Authors: Spearpoint Michael , Stallwood Matt 
Published: April 2024

Guidance issued by organisations such as fire and rescue services, insurers and governmental bodies across the UK for the fire safety design of covered car parks is changing in response to the projected rapid growth in electric vehicle (EV) use. This new guidance is impacting the provision of parking bays, particularly in residential and mixed-use buildings. This paper considers whether EVs in covered car parks pose a greater fire risk than internal combustion engine vehicles (ICEVs) using recent data on the ignition frequency and the burning characteristics of EVs. The recommended mitigating fire safety measures within the new guidance are assessed with a focus on detection, smoke ventilation, sprinkler systems and structural performance as these have the potential to have the greatest impact on a building fire safety design. The paper indicates that the recommendations may not align with available evidence which challenges a balanced approach to fire safety requirements to prevent over-specification that could affect the feasibility of building designs. This paper summarises recent fire safety guidance in the UK on the use of electric vehicles (EVs) in covered car parks. Factors that contribute to the risk posed by EVs are investigated and practical design values for heat release and fire growth are suggested. Key recommended fire safety measures proposed in the guidance have been assessed against existing evidence. The findings are useful to stakeholders involved in the design of covered car parks to allow a balanced approach to their fire safety requirements.
Effect of geography on the use of ultrafiltration during cardiac surgery with cardiopulmonary bypass
Authors: Patel Kirti P , Stammers Alfred H , Tesdahl Eric A , Chores Jeffrey , Beckmann Scott R , Baeza Jennifer , Petterson Craig M , Thompson Ty , Baginski Alexander , Firstenberg Michael , Jacobs Jeffrey P 
Published: April 2024

Background Ultrafiltration (UF) is a common practice during cardiopulmonary bypass (CPB) where it is used as a blood management strategy to reduce red blood cell (RBC) transfusion, minimize adverse effects of hemodilution, and reduce proinflammatory mediators. However, its clinical utilization has been shown to vary throughout the continents. Purpose The purpose of this investigation was to assess the distribution of UF use across the United States. Data Collection Data on UF use during cardiac surgery was obtained from a national (United States) perfusion database for adult cardiac procedures performed from January 2016 through December 2018. Study Sample Four geographical regions were established: Northeast (NE), South (SO), Midwest (MW) and West (WE). The primary endpoint was the use of UF with secondary endpoints UF volume, CPB and anesthesia asanguineous volumes, intraoperative allogeneic RBC transfusion, nadir hematocrit and urine output (UO). 92,859 adult cardiac cases from 191 hospitals were reviewed. Results The NE and the WE had similar usages of UF (59.9% and 59.7% respectively), which were higher than the MW and the SO (38.6% and 34.9%, p < .001). When UF was utilized, the median [IQR] volume removed was highest in the NE (1900 [1200-2800]mL), and similar in all other regions (WE 1500 [850-2400 mL, MW 1500 [900-2300]mL and SO 1500 [950-2200]mL, p < .001. Median total UO was lowest in the NE 400 [210,650]mL vs all other regions ( p < .001), and remained so when indexed by patient weight and operative time (NE-0.8 [0.5, 1.3]mL/kg/hour, MW-1.1 [0.7, 1.8] mL/kg/hour, SO-1.3 [0.8, 2.0]mL/kg/hour, WE-1.1 [0.7, 1.3]mL/kg/hour, p < .001. Intraoperative RBC transfusion rate was highest in the SO (21.3%) and WE (20.5%), while similar rates seen in the NE (16.2%) and MW (17.6%), p < .001. Conclusions Across the United States there is geographic variation on the use of UF. Further research is warranted to investigate why these practice variations exist and to better understand and determine their reasons for use.
Practical training concept for perfusionists at the heart and diabetes center Nordrhein-Westfalen
Authors: Klüß Christian , Giesbrecht André , Rudloff Markus , von Dossow Vera , Sandica Eugen , Gummert Jan 
Published: April 2024

Background Increasing regulations and requirements of advisory bodies, in particular the Joint Federal Committee and the Medical Service of the health insurance funds, make it necessary to employ only demonstrably well-trained perfusionists. The minimum requirement for this staff is EBCP certification. Currently there is limited availability of such specialists on the German market. Therefore, the qualification of young people in this area is of central importance. The aim of this paper is to strengthen the training of perfusionists at our centre, to standardise the process and to provide the respective student with a “roadmap” to their internship. Material & Methods The structure is based on a rough division of the 24 weeks of internship. This is described in detail in the following and is backed up with the learning objectives for the respective time periods. Results At our centre, practical training has been standardized and clear responsibilities have been defined. Furthermore, as a centre of maximum care in the field of cardiac surgery, we can offer students the necessary number of perfusions in just six months to meet the requirements of the ECBP for practical training. According to this concept, 20 perfusionists have been successfully trained in the last 8 years. All of them have passed the exams and have been certified according to EBCP. Conclusion The aim of the practical semester is for the student to be in a position at the end of the semester to independently supervise simple cardiac surgery procedures with the aid of the Extra- Corporal Circulation (ECC) and to carry this out in accordance with the currently valid guidelines and directives (1–8) and the departmental procedural instructions based on them. Great emphasis is placed to the students becoming aware of their competence to act, knowing their limits and being able to assess when these limits have been reached and the involvement of experienced colleagues is necessary to ensure patient safety.
Epicardial adipose tissue (EAT) thickness on non-gated chest CT as an alternative to EAT volume on cardiac CT
Authors: Vural Murat , Dölek Betül Akdal , Kılıçkap Gülsüm , Kübra Bahadır Gülsüm , Celal Güneş Yasin 
Published: April 2024

Background Epicardial adipose tissue (EAT) volume is usually measured with ECG-gated computed tomography (CT). Measurement of EAT thickness is a more convenient method; however, it is not clear whether EAT thickness measured with non-gated CT is reliable and at which localization it agrees best with the EAT volume. Purpose To examine the agreement between ECG-gated EAT volume and non-gated EAT thickness measured from various localizations and to assess the predictive role of EAT thickness for high EAT volume. Material and Methods EAT thickness was measured at six locations using non-contrast thorax CT and EAT volume was measured using ECG-gated cardiac CT (n = 68). The correlation and agreement (Bland–Altman plots) between the thicknesses and EAT volume were assessed. Results EAT thicknesses were significantly correlated with EAT volume ( P < 0.001). The highest correlation (r = 0.860) and agreement were observed for the thickness adjacent to the right ventricular free wall. Also, EAT thickness at this location has a strong potential for discriminating high (>125 cm3) EAT volume (area under the ROC curve=0.889, 95% CI=0.801–0.977; P < 0.001). The sensitivity, specificity, and positive and negative predictive values of EAT thickness for high EAT volume were 76.5%, 88.2%, 68.4%, and 91.8%, respectively, for the cutoff value of 5.75 cm; and 47.1%, 100%, 100%, and 85%, respectively, for the cutoff value of 8.10 cm. Conclusion EAT thickness measured on non-gated chest CT adjacent to the right ventricular free wall is a reliable and easy-to-use alternative to the volumetric quantification and has a strong potential to predict high EAT volume.
Treatment of chronic post-radiation cystitis with trans-urethral amniotic bladder therapy appears durable at 9 months: A clinical study
Authors: Lutchka Jonathan , Vercnocke Jack , Fisher Emily , Radoiu Codrut , Jeberaeel Julian , Lucas Steven , Dhar Nivedita 
Published: April 2024

Purpose: Chronic radiation cystitis (CRC) develops after radiation therapy and can present with symptoms like urinary frequency, urgency, pelvic pain, and nocturia. We have previously reported that amniotic bladder therapy (ABT) provides symptomatic improvement in refractory CRC patients for up to 3 months. Herein, we evaluated the durability of ABT up to 6 months. Materials and methods: CRC patients recalcitrant to previous treatments received ABT comprised of intra-detrusor injections of 100 mg micronized AM diluted in 10 mL 0.9% preservative-free sodium chloride. Clinical evaluation and questionnaires (Interstitial Cystitis Symptom Index (ICSI), Interstitial Cystitis Problem Index (ICPI), Bladder Pain/Interstitial Cystitis Symptom Score (BPIC-SS), Overactive Bladder (OAB) Assessment Tool, SF-12 Health Survey) were repeated at pre-op and 2, 4, 8, 12, 16, 20, 24, and 36 weeks post-injection. Results: Five consecutive patients with a mean age of 64.4 ± 20.1 years with a median CRC duration of 10 years were included and followed for 6 months. After ABT, the lower urinary tract symptoms improved as early as 2 weeks and were maintained up to 20 weeks. BPIC significantly improved from 36.6 ± 1.1 at baseline to 12.6 ± 1.5 at 16 weeks and 13.8 ± 2.9 at 20 weeks. At 24 and 36 weeks, the improvement was maintained in four (80%) of the five patients (BPIC = 13.8 ± 1.0). Uroflow assessment showed voiding volume improved two-fold in four of the five patients at 24 weeks compared to baseline. Conclusion: Our data suggest that a significant number of CRC patients may have durable benefit after ABT. Despite this, some of them can show symptoms rebound at 24 weeks.
Effect of overweight/obesity on relationship between fractional exhaled nitric oxide and airway hyperresponsiveness in Chinese elderly patients with asthma
Authors: Chen Fengjia , Liu Yangli , Sun Long-hua , Zeng Zhimin , Huang Xinyan 
Published: April 2024

Purpose: This retrospective study investigates the influence of overweight and obesity status on pulmonary function, airway inflammatory markers, and airway responsiveness in elderly asthma patients. Methods: Patients with asthma older than 65 years old who completed a bronchial provocation test (BPT) or bronchial dilation test (BDT) and a fractional exhaled nitric oxide (FeNO) test between December 2015 and June 2020 were identified retrospectively for this study. All of the patients were categorized into overweight/obesity and non-obesity groups based on their BMI. Pulmonary function test (PFT) and FeNO measurements were accomplished according to the 2014 recommendations of the Chinese National Guidelines of Pulmonary Function Test and American Thoracic Society/European Respiratory Society recommendations, respectively. Results: A total of 136 patients with an average age of 71.2 ± 5.40 years were identified. The average BMI was 23.8 ± 3.63, while the value of FeNO was 42.3 ± 38.4 parts per billion (ppb). In contrast to the non-obesity group, which had a value of 48.8 ± 43.1 ppb for FeNO, the overweight/obesity group had a significant lower value of 35.4 ± 31.4 ppb. There was no significant difference in the proportion of individuals with high airway hyperresponsiveness between the overweight/obesity and non-obesity groups (96 patients in total). Multiple linear regression analysis established an inverse correlation between FeNO and Provocation concentration causing a 20% fall in FEV1(PC20) but excluded significant relationships with age and BMI. The model’s R is 0.289, and its p value is 0.045. Conclusion: The elderly Chinese Han asthmatics with overweight/obesity had lower FeNO levels than those with non-obese according to our findings. In addition, the FeNO level was inversely correlated between FeNO levels and PC20 in elderly asthmatics.
Patient Satisfaction After Cosmetic Breast Surgery Utilizing the Free Nipple Graft Technique
Authors: Pandya Yagnik , Sessa Alberico , Doshi Arya , Caceres Aileen , Garner Dan 
Published: April 2024

Introduction: Breast surgery using the free nipple areolar graft (FNG) technique is a less frequently utilized technique; however, a very safe alternative to other available dermoglandular pedicles when nipple areola vascularity is of concern. One of the drawbacks with FNG technique is the loss of tactile sensation and the overall postoperative esthetic appearance of the nipple areola complex (NAC). Objective: Our aim was to study patient satisfaction, specifically in regard to NAC sensation and esthetic appearance of the NAC in patients who underwent breast surgery utilizing the FNG technique. Study Design: This study is a case series of patients undergoing cosmetic breast procedures utilizing the FNG technique. Postoperative outcomes were evaluated both by the clinician and the patient by completing a survey questionnaire. Methods: We conducted a 3 month postoperative patient satisfaction survey utilizing a questionnaire in 74 patients who underwent various cosmetic surgical procedures on the breast using the FNG technique. Patients were also objectively evaluated by a physician during the same visit. Patients rated their NAC sensation and esthetic appearance on a scale of 1 to 5 and 1 to 10, respectively, and the physician rated the NAC loss on a scale of 1 to 5. Results were reported as percentages of total patients in each group. Results: Our results indicated that over 85% of patients in our study had more than 50% tactile sensation to the NAC at 3 months. We also found that over 75% of patients were very satisfied with the esthetics of the NAC after these procedures. Conclusions: We conclude that the risk of sensation loss to the NAC and patient satisfaction in regard to esthetic appearance of the NAC is better than what is believed to be and that the FNG technique may possibly be an underutilized tool in the surgeon’s toolbox.
Eriocitrin in the Treatment of Diabetic Nephropathy: Amelioration Against Oxidative Burst and Inflammation Approach
Authors: Deng Hui , Li Yarong , Han Shulan , Lan Min , Cui Liqin , Alahmadi Tahani Awad , Alharbi Sulaiman Ali , Li Zhong 
Published: April 2024

Background Diabetes mellitus (DM) induces hyperglycemia and oxidative stress in the kidneys and may cause kidney dysfunction. Diabetic nephropathy (DN) is a prolonged problem of DM with limited treatment. Purpose In this work, we planned to investigate the beneficial effects of eriocitrin, a natural flavanol found in citrus fruits, against DM-induced DN in rats. Materials and Methods For the induction of DN, animals were fed a high-fat diet and were administered with streptozotocin (35 mg/kg). After induction, eriocitrin (50 or 100 mg/kg) was administered to the DM rats, and their changes in feed intake, body weight, blood glucose levels, and blood samples were monitored on a daily basis. The oxidative stress markers were estimated by using standard protocols. The renal function markers such as the activity of lactate dehydrogenase (LDH), creatinine, and blood urea nitrogen levels were investigated by using kits. The kidney injury molecule (KIM-1) and pro-inflammatory markers were determined by using commercial kits. The kidney tissues were studied histopathologically. Results Eriocitrin considerably reduced the body weight and food consumption in DM-induced rats. Furthermore, eriocitrin restored the values of biochemical parameters such as glucose, glycated hemoglobin, urea, creatinine, LDH, serum cholesterol, and triglycerides to near-normal levels. Moreover, the antioxidant properties of eriocitrin markedly suppressed the oxidative and inflammatory markers by continuing the antioxidant/reactive oxygen species balance. Furthermore, the biochemical parameters are well correlated with histopathological examination. Conclusion Our results provide valuable scientific information, that supports the therapeutic role of eriocitrin and its protective effects in DM and its complications (DN).