bluuebunny/crossref_metadata_2025_split huggingface dataset:
Tp‐e Interval, Tp‐e/QT Ratio, and Tp‐e/QTc Ratio are Prolonged in Patients with Moderate and Severe Obstructive Sleep Apnea
Authors: KILICASLAN FETHI , TOKATLI ALPTUG , OZDAG FATIH , UZUN MEHMET , UZ OMER , ISILAK ZAFER , YIGINER OMER , YALCIN MURAT , GUNEY MEHMET SENOL , CEBECI BEKIR SITKI 
Published: June 2012

Background:

Prolongation of the peak and the end of T wave (Tp‐e) has been reported to be associated with ventricular arrhythmias. Tp‐e/QT ratio and Tp‐e/QTc ratio are used as an index of ventricular arrhythmogenesis. An increased incidence of ventricular arrhythmias has been reported in patients with obstructive sleep apnea (OSA). The aim of this study was to assess ventricular repolarization in patients with OSA by using Tp‐e interval, Tp‐e/QT ratio, and Tp‐e/QTc ratio.
Methods:

We have studied 72 patients who underwent overnight polysomnography (PSG) between the years 2010–2011 at our institution. Patients with moderate and severe OSA (23 patients; mean age: 45±10), according to the apnea‐hypopnea index, constituted the study group. Patients with normal PSG (23 patients; mean age: 42±11) were used as the control group. In all patients, Tp‐e interval, Tp‐e/QT ratio, Tp‐e/QTc ratio, as well as some other electrocardiogram intervals were measured. Independent samples t‐tests were used for comparison of continuous and categorical variables and correlations were calculated by Spearman rank correlation.
Results:

Although QT and QTc intervals were not different between the groups, mean Tp‐e interval (81.6±11.1 msn; 63.9±7.3 msn; respectively; P < 0.001), Tp‐e/QT ratio (0.21±0.03; 0.17±0.02; respectively; P < 0.001), and Tp‐e/QTc ratio (0.20±0.03; 0.16±0.02; respectively; P < 0.001) were prolonged in the study group compared to the control group. Correlation analysis showed a significant positive correlation between the presence of moderate and severe OSA and Tp‐e interval (r = 0.72; P < 0.001), Tpe/QT ratio (r = 0.70; P < 0.001), and Tp‐e/QTc ratio (r = 0.70; P < 0.001).
Conclusions:

Tp‐e interval, Tp‐e/QT ratio, and Tp‐e/QTc ratio are prolonged in patients with moderate and severe OSA patients. There is a positive correlation between the presence of OSA and Tp‐e interval, Tp‐e/QT ratio, and Tp‐e/QTc ratio.
(PACE 2012; 35:966–972)
Trends in Midwife‐Attended Births in the United States, 1989‐2009
Authors: Declercq Eugene 
Published: June 2012

Introduction: Data on attendance at birth by midwives in the United States have been available on the national level since 1989. Rates of certified nurse‐midwife (CNM)–attended births more than doubled between 1989 (3.3% of all births) and 2002 (7.7%) and have remained steady since. This article examines trends in midwife‐attended births from 1989 to 2009.Methods: The data in this report are based on records gathered as part of the US National Standard Certificate of Live Birth from a public use Web site, Vital Stats (http://www.cdc.gov/nchs/VitalStats.htm), that allows users to create and download specialized tables.Results: Between 2007 and 2009, the proportion of all births attended by CNMs increased by 4% from 7.3% of all births to 7.6% and a total of 313,516. This represents a decline in total births attended by CNMs from 2008 but a higher proportion of all births because total US births dropped at a faster rate. The proportion of vaginal births attended by CNMs reached an all‐time high of 11.4% in 2009. There were strong regional patterns to the distribution of CNM‐attended births. Births attended by “other midwives” rose to 21,787 or 0.5% of all US births, and the total proportion of all births attended by midwives reached an all‐time high of 8.1%. The race/ethnicity of mothers attended by CNMs has shifted over the years. In 1990, CNMs attended a disproportionately high number of births to non‐white mothers, whereas in 2009, the profile of CNM births mirrors the national distribution in race/ethnicity.Discussion: Midwife‐attended births in the United States are increasing. The geographic patterns in the distribution of midwife‐attended births warrant further study.
Electric and Magnetic Properties of Bilayered Lead‐Free Piezoelectric and Multiferroic Bi0.9Dy0.1FeO3/K0.5Na0.5NbO3 Thin Films
Authors: Chen Ling , Ren Wei , Ye Zuo‐Guang , Tian Aifen , Wu Xiaoqing , Shi Peng , Chen Xiaofeng 
Published: June 2012

Composite lead‐free piezoelectric and multiferroic thin films consisting of
Bi

0.9

Dy

0.1

FeO

3 (
BDF
) and
K

0.5

Na

0.5

NbO

3 (
KNN
) nanolayers were prepared on the
Pt
/
TiO

2/
SiO

2/
Si
substrates by pulsed laser deposition. The bilayered
BDF
/
KNN
films exhibited a preferential (100)‐orientation and much enhanced ferroelectric properties (2P
r = 26.5 μC/cm2, 2E
c = 369.2 kV/cm) as compared to those of single layer
BDF
or
KNN
thin film. In addition, the bilayered
BDF
/
KNN
films also showed ferromagnetic behavior at low temperature (2M
r = 1.57 emu/cm3, 2H
c = 3 kOe). The enhanced ferroelectric properties of the bilayered
BDF
/
KNN
thin films were attributed to the significantly reduced leakage current arising from the enhanced crystallinity and the interface reaction of the
BDF
and
KNN
nanolayers. An effective piezoelectric coefficient d
33 of 12 pm/V was measured on the bilayered films.
What is the gold standard for intrapartum fetal monitoring?
Authors: YLI BRANKA M. , KESSLER JØRG , EIKELAND TORUNN , HUSTAD BERIT LUNDEN , DRAGNES WINNIE , HENRIKSEN TORE 
Published: June 2012

AbstractThe health authorities of Stockholm county recently published a Health Technology Assessment report: “Fetal monitoring with computerized STAN analysis during labor – a systematic review” with the aim to ensure that high quality research information on costs, effectiveness and broader impact of health technologies is analysed and presented in the most efficient way for those who use, manage and work in this field. The report claims to analyse available research in relation to ST interval analysis of fetal electrocardiogram (STAN) and concludes that scientific evidence for advantages of the STAN technology for maternal and fetal outcome was insufficient and that clinical use cannot be recommended and should be restricted to research protocols. The Norwegian reference group for fetal surveillance points out that the report suffers from two insufficiencies: selection bias by not providing a complete collection of the evidence for the clinical performance of the STAN technology and, secondly, that it does not provide evidence‐based alternative methods.
Topoisomerase expression in oral squamous cell carcinoma: relationship with cancer stem cells profiles and lymph node metastasis
Authors: Oliveira‐Costa João Paulo , Oliveira Lucinei Roberto , da Silveira Giórgia Gobbi , Soave Danilo Figueiredo , Soares Fernando Augusto , Ribeiro‐Silva Alfredo 
Published: June 2012

J Oral Pathol Med (2012) 41: 762–768Background:  The relationship between predictive proteins and tumors presenting cancer stem cells (CSCs) profiles in oral tumors is still poorly understood. This study aims to identify the relationship between topoisomerases I, IIα, and IIIα and putative CSCs immunophenotype in oral squamous cell carcinoma (OSCC) and determine its influence on prognosis.Methods:  The following data were retrieved from 127 patients: age, gender, primary anatomic site, smoking and alcohol intake, recurrence, metastases, histologic classification, treatment, and survival. An immunohistochemical study for topoisomerases I, IIα, and IIIα was performed in a tissue microarray containing 127 paraffin blocks of OSCCs.Results:  In univariate analysis, topoisomerases expression showed significant differences according to CSCs profiles and p53 immunoexpression, but not with survival. Topoisomerases IIα and IIIα also showed significant relationship with lymph node metastasis. The multivariate test confirmed these associations.Conclusions:  The results that all topoisomerases correlates with OSCC CSCs may indicate a role for topoisomerases in head and neck carcinogenesis. Notwithstanding, it is plausible that other members of topoisomerases family could represent novel therapeutical targets in oral squamous cell carcinoma.
Expression of Wilms’ tumor 1 (WT1) in oral squamous cell carcinoma
Authors: Mikami Toshinari , Hada Tomohiro , Chosa Naoyuki , Ishisaki Akira , Mizuki Harumi , Takeda Yasunori 
Published: June 2012

J Oral Pathol Med (2013)42: 133–139Background:  The product of the Wilms’ tumor gene, WT1 protein, is a tumor antigen for various kinds of cancer, and WT1 peptide‐based cancer immunotherapy is widely anticipated as a new possibility for cancer treatment. The aim of this study was to investigate the expression of WT1 from quantitative and morphological perspectives in oral squamous cell carcinoma (OSCC), the most widespread malignant neoplasm of the oral cavity.Methods:  Six OSCC cell lines and tissue sections from 29 OSCC patients were analyzed. To detect WT1 expression, reverse transcription‐polymerase chain reaction analysis (RT‐PCR), real‐time PCR, Western blots, and immunofluorescence flow cytometry for WT1 were performed on the cell lines, and immunohistochemistry and fluorescence in situ hybridization (FISH) were performed on the tissue sections.Results:  WT1 mRNA was found overexpressed in one of the six OSCC cell lines, with expression levels higher than that seen in human leukemia cell line (K562). Immunohistochemical analysis of tissue sections showed overexpression of WT1 protein in two patients, concentrated mainly in the cytoplasm of the outer one to three cell layers of the cancer nests. This was consistent with the expression of WT1 mRNA observed by FISH. Meanwhile, WT1 was not detected on normal oral epithelium. WT1 protein was detected on actively proliferating cancer nests and even on elongated epithelial ridge where new droplet‐cancer‐nests were being formed and starting infiltration toward subepithelial layer.Conclusions:  The results suggest that WT1 plays an important role in the pathogenesis of some types of OSCC, particularly in proliferation of the cancer cells.
Tuning Multiple Motor Travel via Single Motor Velocity
Authors: Xu Jing , Shu Zhanyong , King Stephen J. , Gross Steven P. 
Published: June 2012

AbstractMicrotubule‐based molecular motors often work in small groups to transport cargos in cells. A key question in understanding transport (and its regulation in vivo) is to identify the sensitivity of multiple‐motor‐based motion to various single molecule properties. Whereas both single‐motor travel distance and microtubule binding rate have been demonstrated to contribute to cargo travel, the role of single‐motor velocity is yet to be explored. Here, we recast a previous theoretical study, and make explicit a potential contribution of velocity to cargo travel. We test this possibility experimentally, and demonstrate a strong negative correlation between single‐motor velocity and cargo travel for transport driven by two motors. Our study thus discovers a previously unappreciated role of single‐motor velocity in regulating multiple‐motor transport.
Cyclic Changes in the Level of the Innate Immune Molecule, Surfactant Protein‐A, and Cytokines in Vaginal Fluid
Authors: MacNeill Colin , de Guzman Glendell , Sousa Grace E. , Umstead Todd M. , Phelps David S. , Floros Joanna , Ahn Kwangmi , Weisz Judith 
Published: June 2012

ProblemOur knowledge of the innate host defenses in the vagina, a site where these defenses are essential to protecting the host upper reproductive tract from invasion by pathogens, is as yet rudimentary. Specifically, little is known about the pattern‐recognition component of vaginal innate immunity, the relationship of pattern‐recognition molecules to known cytokine levels, and the role of gonadal hormones in their regulation.Method of studyWe measured levels of Surfactant Protein‐A (SP‐A), a prototypic innate pattern‐recognition protein, in vaginal fluid (VF) and correlated them with levels of IL‐1β and IL‐8, two cytokines known to be present in VF. Assays were carried out on VF collected over three consecutive cycles from ten healthy naturally cycling women who were sampled at three specific time points in the menstrual cycle. The three time points were chosen to enable correlation with distinct hormonal states.ResultsBoth SP‐A and cytokines levels were highest 5–6 days after menses (P < 0.05) and were significantly lower at ovulation and mid‐luteal phase.ConclusionSurfactant Protein‐A, like other host defense molecules in the reproductive tract, appears to be regulated by gonadal hormones.
Rethinking Respite Policy for People With Intellectual and Developmental Disabilities
Authors: Chan Jeffrey , Merriman Brian , Parmenter Trevor , Stancliffe Roger 
Published: June 2012

AbstractRespite care is one of a range of support services typically available to carers of people with dependencies who need a break from caring, and the factors that influence the need for respite care are generally similar irrespective of the nature of the dependencies. Hence, the expectations of families potentially have policy and service provision implications regardless of the jurisdiction. However, there is considerable variability in the provision of services, not only between jurisdictions, with differing levels of service development, but also within jurisdictions. The history of disjointed service provision suggests the need for a rethink of respite policy. The authors discuss the conceptual framework and prevalent thinking on respite policy such as a shared understanding of respite care among stakeholders. In turn, this shared understanding is seen as generating a move toward integrated service development, recasting respite as part of a continuum of family support services in which funding policies give families more control. The authors conclude that respite care provided in an integrated framework moves beyond the basic function of a break in caring to one of supporting family coping and resilience.
Mapping Future Research in Disabilities—Research Initiatives in Intellectual Disabilities in India: Report of a National Interdisciplinary Meeting
Authors: Cohen Libby , Brown Roy I. 
Published: June 2012

AbstractA meeting organized under the auspices of the International Association for the Scientific Study of Intellectual Disabilities (IASSID) Academy on Education, Teaching and Research was held in March 2011 at the India International Centre in New Delhi, India, with the explicit purpose of helping establish a road map for future research in intellectual disabilities (ID) in India and to forge alliances among like‐minded researchers and practitioners to move forward on countrywide research. The participants were drawn from nongovernmental and governmental groups, private consultancies, psychology, researchers, and policymakers, and they were interested in research dissemination, research methodologies, and research ethics. The participants developed a framework for research strategies and defined important areas for further research in ID for India. Based on the discussions, the following research strategy areas were identified: prevalence studies, human ethics, human rights, prevention, interventions, research syntheses of existing research that has been conducted in India, dissemination of existing research, building research capacity, and disaster preparedness. As each priority area required further discussion and feedback, agreement was achieved that such further discussions and collaborations would follow. The follow‐up is a process which involves the simultaneous and synergistic development of policies and practices at the application and governmental levels.
Impact of Dementia‐derived Nonpharmacological Intervention Procedures on Cognition and Behavior in Older Adults With Intellectual Disabilities: A 3‐year Follow‐up Study
Authors: De Vreese Luc P. , Mantesso Ulrico , De Bastiani Elisa , Weger Elisabeth , Marangoni Annachiara C. , Gomiero Tiziano 
Published: June 2012

AbstractDementia appears at a higher rate among some adults with intellectual disabilities (ID) and this potentially poses a greater risk of nursing home admission. Yet, to date, there is no evidence on the efficacy of general dementia‐derived environment‐, personnel‐, and patient‐oriented intervention strategies in delaying onset of dementia or in slowing down its rate of progression in this population. To investigate the feasibility and efficacy of a multicomponent nonpharmacological approach, the authors studied a sample of 14 adults with worsening cognition and everyday functioning who were no longer manageable by their family or staff in day centers or group homes, and who were relocated in a model special care unit (SCU) designed to proactively accommodate the needs of people with ID and dementia. Baseline level and rate of decline across a 3‐year period were assessed by means of the Dementia Questionnaire for Persons with Intellectual Disabilities and compared to two control groups not in dementia‐capable programs matched for age, sex, and severity of ID. After 3 years, the authors found some improvement in cognition and stabilization in everyday functioning and behaviors in the SCU residents and a worsening in the control groups. The authors noted that enrollment in a dementia‐capable program facilitated daily practice of residents' residual skills and abilities, enhancing their memory and verbal communication, that the prosthetic environment contributed to activity maintenance and appropriate intellectual challenges, and that the greater participation on an individual level added to the skill maintenance. Although the interpretation of these positive findings is not straightforward, they confirm the validity of this “in‐place progression” model and provide a platform for continuing progress in person‐centered services and care for aging persons with ID.
Role of Apheresis and Dialysis in Pediatric Living Donor Liver Transplantation: A Single Center Retrospective Study
Authors: Sanada Yukihiro , Mizuta Koichi , Urahashi Taizen , Ihara Yoshiyuki , Wakiya Taiichi , Okada Noriki , Yamada Naoya , Koinuma Toshitaka , Koyama Kansuke , Tanaka Shinichiro , Misawa Kazuhide , Wada Masahiko , Nunomiya Shin , Yasuda Yoshikazu , Kawarasaki Hideo 
Published: June 2012

AbstractIn the field of pediatric living donor liver transplantation, the indications for apheresis and dialysis, and its efficacy and safety are still a matter of debate. In this study, we performed a retrospective investigation of these aspects, and considered its roles. Between January 2008 and December 2010, 73 living donor liver transplantations were performed in our department. Twenty seven courses of apheresis and dialysis were performed for 19 of those patients (19/73; 26.0%). The indications were ABO incompatible‐liver transplantation in 11 courses, fluid management in seven, acute liver failure in three, renal replacement therapy in two, endotoxin removal in two, cytokine removal in one, and liver allograft dysfunction in one. Sixteen courses of apheresis and dialysis were performed prior to liver transplantation for 14 patients. The median IgM antibody titers before and after apheresis for ABO blood type‐incompatible liver transplantation was 128 and eight, respectively (P < 0.05). Eleven courses of apheresis and dialysis were performed post liver transplantation for 10 patients. The median PaO2/FiO2 ratio before and after dialysis for fluid overload was 159 and 339, respectively (P < 0.05). No bleeding or technical complications attributable to apheresis and dialysis occurred. The 1‐year survival rate of the patients was 100%. Apheresis and dialysis in pediatric living donor liver transplantation are effective for antibody removal in ABO‐incompatible liver transplantation, and fluid management for acute respiratory failure.
Associations between adolescent nutrition behaviours and adolescent and parent characteristics
Authors: WILLIAMS Susan L. , MUMMERY W. Kerry 
Published: June 2012

AbstractAim:  This study examined adolescent nutrition behaviours and associations with a range of adolescent and parent characteristics to underpin the development of key objectives for focus in the development of school‐based interventions for the prevention of adolescent overweight/obesity.Methods:  Three hundred and sixty‐two adolescents from six secondary schools completed questionnaires regarding their nutrition behaviours, physical activity and sedentary activities, and 349 parents completed questionnaires to report their height and body weight, nutrition behaviours, physical activity, and values of adolescent obesity‐related behaviours. Adolescent height and body weight were objectively measured for calculation of body mass index. Logistic regression (P < 0.05) and Pearson chi‐square analyses of 295 matched adolescent and parent questionnaires were conducted to examine associations.Results:  Adolescent healthy nutrition behaviours were negatively associated with time spent in small screen recreation (odds ratio 0.48, P= 0.02) and positively associated with time spent in sedentary education (odds ratio 2.44, P= 0.004) and physical activity (odds ratio 2.53, P= 0.03). Gender differences were found. No associations were found between adolescent healthy nutrition behaviours and adolescent body mass index, parent body mass index, parent nutrition behaviours or parent values of adolescent health behaviours.Conclusions:  Interventions to promote adolescent healthy nutrition behaviours should be gender‐specific and include action around a range of obesity‐related health behaviours including physical activity and time spent in small screen recreation.
Sugary drink consumption behaviours among young adults at university
Authors: O'LEARY Fiona , HATTERSLEY Libby , KING Lesley , ALLMAN‐FARINELLI Margaret 
Published: June 2012

AbstractAim:  Sugary drink consumption is associated with weight gain, and young adults are the highest consumers. To inform a university healthy beverage intervention, we studied the settings and the types and amounts of sugary drinks consumed by a sample drawn from the student population.Methods:  Fifty university students (24 male) were recruited to keep records of all beverages consumed over four consecutive days. The records were analysed by gender, drink category and consumption setting.Results:  Males drank marginally more sugary drinks than females (median daily intake of 526 mL compared with 300 mL, P = 0.06). Median energy intake from sugary drinks was 928 kJ for males and 481 kJ for females. Carbonated soft drinks and fruit‐based drinks accounted for 64% of energy from sugary drinks for males; and fruit and sweetened milk‐based drinks accounted for 68% of energy for females. Half of all sugary drink consumption occurred at home followed by social settings.Conclusion:  Health promotion programmes aiming to reduce sugary drink consumption in this group would benefit from gender‐differentiated strategies with respect to types of drinks consumed with a focus on the home and social settings.