bluuebunny/crossref_metadata_2025_split huggingface dataset:
Calculated whole blood viscosity in non-diabetic subjects with asymptomatic carotid atherosclerosis: How insulin resistance may affect blood viscosity
Authors: Caimi G. , Urso C. , Brucculeri S. , Lo Presti R. , Carlisi M. 
Published: June 2024

BACKGROUND AND OBJECTIVE: Asymptomatic atherosclerosis is an important early marker of vascular damage and, among its risk factors, hemorheological alterations play an important role. PATIENTS AND METHODS: In a cohort of 85 non-diabetic subjects with asymptomatic carotid atherosclerosis (ACA), we have measured whole blood viscosity (cWBV) according to the haematocrit and plasma fibrinogen level. The cWBV distinguish the subgroup of ACA subjects with 3-5 cardiovascular risk factors (CRFs) from that with 1-2 CRFs and the same behavior is present for haematocrit and plasma fibrinogen level. Therefore, we divided the whole group of ACA subjects according to the medians of the four surrogate indexes with an insulin resistance degree of TG/HDL-C, TyG, VAI and LAP. RESULTS: The analysis of the correlation between cWBV and each index of insulin resistance has shown that no correlation is present in the whole group and in the group of ACA subjects with 1-2 CRFs, while in the subgroup with 3-5 CRFs there is a positive correlation between cWBV with TG/HDL-C and TyG at a low degree of statistical significance. CONCLUSIONS: The date underline that subjects with this clinical condition have an unaltered evaluation of the cWBV compared to the other indices.
Baicalein alleviates palmitic acid-induced endothelial cell dysfunction via inhibiting endoplasmic reticulum stress
Authors: Chen Jian , Chen Fei-yu , Lu Chan-jun , Yi Sheng-wu 
Published: June 2024

OBJECTIVE: Endothelial cells play a critical role in maintaining vascular function and kinetic homeostasis, but excessive accumulation of palmitic acid (PA) may lead to endoplasmic reticulum stress and trigger endothelial cell dysfunction. Baicalin (BCL), a natural plant extract, has received widespread attention for its biological activities in anti-inflammation and anti-oxidative stress. However, the mechanism of BCL on PA-induced endothelial cell dysfunction is unclear. Therefore, the aim of this study was to investigate whether BCL could inhibit PA-induced endoplasmic reticulum stress and thus attenuate endothelial cell dysfunction. METHODS: Human umbilical vein endothelial cells (HUVECs) were divided into Control, PA, PA + BCL-10 μM, PA + BCL-20 μM, and PA + BCL-50 μM groups. The PA group was treated with PA (200 μM), while the PA + BCL groups were co-treated with different concentrations of BCL (10 μM, 20 μM, 50 μM) for 24 hours. Cell viability was detected by MTT. Cell migration ability was determined by Transwell assay, apoptosis level by flow cytometry, and tube formation ability by tube formation assay. Finally, the levels of apoptosis-related proteins (Bax, Bcl-2, and cleaved caspase-3) and angiogenesis-related proteins (VEGFA and FGF2) were detected by western blot, MMP-9, as well as the protein levels of endoplasmic reticulum stress biomarkers (GRP78, CHOP, PERK, and ATF4). RESULTS: The results at the cellular level showed that cell viability, migration ability and tube formation ability of PA-induced HUVECs were significantly reduced, while apoptosis level was significantly increased. However, administration of different concentrations of BCL significantly enhanced PA-induced cell viability, migration ability and tube formation ability of HUVECs while inhibiting apoptosis. The results of protein levels showed that the protein levels of Bax and cleaved caspase-3 were observably up-regulated in the cells of the PA group, while the protein level of Bcl-2 was significantly down-regulated; compared with the PA group, the protein levels of Bax and cleaved caspase-3 were much lower and the Bcl-2 protein level was much higher in the PA + BCL group. Additionally, the protein levels of VEGFA, FGF2 and MMP-9 were raised and those of GRP78, CHOP, PERK and ATF4 were lowered in the PA + BCL group of cells in a concentration-dependent manner. CONCLUSION: BCL significantly attenuates PA-induced endothelial cell dysfunction by inhibiting endoplasmic reticulum stress.
A comparative study of blood viscometers of 3 different types
Authors: Oh Ju Seok , Prabhakaran Prem , Seo Dong Kil , Kim Do Yeon , Lee Woonhyoung , Ahn Kyung Hyun 
Published: June 2024

The greater the viscosity of the blood, the more difficult its flow becomes, leading to an increased incidence of diseases caused by blood circulation disorders. These diseases are commonly associated with the cardiovascular and cerebrovascular systems. High blood viscosity is a primary cause of circulatory system diseases. Studies have shown that accurately measuring blood viscosity and applying this data in clinical trials can help prevent circulatory system diseases. Viscosity data can vary depending on the measurement methods used, even when these methods are based on hydrodynamic principles. Despite using approved blood viscometers, the results often differ depending on the type of viscometer used, potentially causing confusion within the medical field. Informing the medical community about these differences and the level of error associated with each measurement method can help reduce this confusion. To our knowledge, the degree of difference in viscosity measurement results due to different measurement methods and the reasons for these differences have not yet been thoroughly explored. In this study, we selected three blood viscosity measurement methods registered with the Ministry of Food and Drug Safety of Korea to analyze the same canine blood. The viscosity measurements were carried out using each device and compared. The parallel plate and scanning capillary methods yielded similar viscosity values, while the cone plate method showed lower viscosity values. The viscosity of blood, as measured by the three viscometers, differed, indicating that more experimental data must be accumulated to evaluate the cause of these differences. In this paper, we identified several causes of inconsistency and suggested measures to avoid this confusion. However, confirming that the test results show systematic differences is expected to assist clinicians who diagnose and prescribe treatments based on blood viscosity results. The findings of this comparative study are anticipated to serve as a starting point for establishing guidelines or standards for blood viscosity measurement methods.
Reidentification and determination of drug susceptibility of Corynebacterium diphtheriae and Corynebacterium ulcerans strains isolated from clinical samples in 2023 in Poland
Authors: Stepuch Agata 
Published: June 2024

BackgroundDespite the fact that the last cases of fully-symptomatic diphtheria were recorded in Poland in 1996 and 2000, infections caused by non-toxin-producing strains of Corynebacterium still occur. According to the epidemiological reports from ECDC in the second half of 2022, there was an increase in the number of diphtheria cases in European Union countries. As a result, the current issue becomes the appropriate preparation of microbiological laboratories for the diagnosis of Corynebacterium microorganisms.ObjectiveReidentification of diphtheria bacilli isolated from clinical samples and to assess the drug susceptibility of C. diphtheriae strains isolated in Poland.Material and methodsThe subject of the research were 18 strains isolated from clinical samples in Poland in 2023. Microbiological and genetic methods were used for the reidentification of the strains. Drug susceptibility was assessed using the disk diffusion method, following the new EUCAST recommendations effective from 2023.ResultsIt was confirmed that all examined strains belonged to the genus Corynebacterium. It was de-monstrated that C. diphtheriae strains proved to be susceptible to increased exposure to benzylpenicillin and cefotaxime. Results obtained using ciprofloxacin allowed categorizing the strains into the intermediate susceptibility category WZE, except for one strain which was resistant to this antibiotic. All tested bacterial strains were susceptible to erythromycin. The C. ulcerans strain exhibited a similar antibiotic resistance profile to penicillin, cefotaxime, and ciprofloxa-cin, with additional detection of resistance to clindamycin. The toxigenicity of the tested strains was excluded.ConclusionsBased on epidemiological data regarding the emergence of new cases of infections caused by Corynebacterium strains, it is advisable to prepare theoretically and practically laboratories for diagnostics to detect potentially toxigenic diphtheria bacilli. Effective methods for the microbiological diagnosis of diphtheria bacilli are available. It is recommended to monitor the susceptibility to antimicrobial agents in all C. diphtheriae isolates
A retrospective study to evaluate the safety and efficacy of intrapleural alteplase in pediatric empyema
Authors: Keivanfar Majid , Kermani Rasool , Hosseinpour Mehrdad , Reisi Mohsen , Poorkaramali Bahar , Mirfendereski Sam 
Published: June 2024

IntroductionMedical treatment of pediatric empyema consists of appropriate antibiotics, chest tube insertion, and intrapleural fibrinolytic drugs to facilitate pleural drainage. There is a lack of consensus about the drug of choice for fibrinolytic therapy, so this study was designed to evaluate the safety and efficacy of intrapleural alteplase in pediatric empyema.Material and MethodsThe medical records of all children with empyema treated with intrapleural alteplase at a university hospital between January 2016 and December 2020 were retrospectively reviewed. Efficacy outcomes were assessed by chest tube output before and after the first dose of alteplase, pleural fluid volume before and after therapy, a need for surgical intervention, and length of hospital stay. Safety was assessed by the frequency and severity of side effects.Results40 children aged 2 months to 9 years hospitalized with empyema received intrapleural alteplase. Thirty patients (75%) experienced full recovery after three doses of intrapleural alteplase. The median length of hospital stay was 16 days. Chest tube output increased significantly after the first dose of alteplase. Pleural fluid volume decreased significantly after treatment. The most common side effect was pain (30%). Two patients experienced severe complications: 1 had a pulmonary hemorrhage and the other experienced a bronchopleural fistula. These patients recovered fully spontaneously.ConclusionsAccording to our results, the administration of intrapleural alteplase was safe
and effective in facilitating pleural drainage in pediatric patients with empyema. However, further clinical trials will be needed to determine the optimal dose, frequency, and duration of intrapleural alteplase treatment.
Pelatihan Tata Cara Shalat yang Benar bagi Masyarakat Dusun Cokel Desa Patarselamat Sangkapura Gresik
Authors: Sholihan  
Published: June 2024

Abstract
Prayer in Islam has a very special position both in terms of how it is commanded and included in special Sharia worship. However, despite this, many people do not understand the correct prayer procedures according to the guidance of Islamic law. Therefore, community service activities regarding training in correct prayer procedures are important to carry out, while the partners in this activity are the people of Cokel Hamlet. The method used in this activity is the Service Learning Method. The use of this method is intended to be able to see and evaluate the results of training implementation which have a direct impact on partner operations. The service learning method can be carried out in three stages: preparation stages, serving stages, and reflection stages. The results of this service ran smoothly and received full support from Cokel Hamlet community leaders because it could provide benefits in improving the quality of worship in the Cokel Hamlet community.
Keywords: Training, Prayers, Prayer Procedures.
Abstrak
Shalat dalam Islam mempunyai kedudukan yang sangat istimewa baik dilihat dari cara memperoleh perintahnya dan termasuk dalam Ibadah Syari’ah khusus. Namun meskipun demikian banyak kalangan masyarakat yang kurang memahami tentang tata cara shalat yang benar menurut tuntunan syariat Islam. Oleh karena itu, kegiatan pengabdian masyarakat mengenai pelatihan tata cara shalat yang benar menjadi penting untuk dilakukan dengan mitra kegiatannya adalah masyarakat Dusun Cokel. Metode yang digunakan dalam kegiatan ini adalah Metode Service Learning. Penggunaan metode ini dimaksudkan untuk dapat melihat dan mengevaluasi hasil dari pelaksanaan pelatihan yang berdampak langsung bagi operasional mitra. Tahapan metode service learning dilakukan dengan tiga tahapan: tahap persiapan, tahap melayani, dan tahap refleksi. Hasil pengabdian ini berjalan dengan lancar dan mendapat dukungan penuh dari tokoh-tokoh masyarakat dusun cokel karena dapat memberikan manfaat dalam peningkatan kualitas ibadah masyarakat dusun cokel.
Kata Kunci: Pelatihan, Shalat, Tata Cara Shalat.
Sistem Pendukung Keputusan Dengan Menggunakan Metode Simple Additive Weighting pada Excelso Coffee Rinjani Semarang
Authors: Ariyanto Lenny , Sokibi Petrus , Kartika Viar Dwi 
Published: June 2024

Excelso coffee is a cafe located in several cities, including in Semarang which began operating in 2017. The process of selecting raw material suppliers that is currently underway still uses the conventional method, which does not have a method for selecting suppliers. With this problem, it is expected to be able to find out the factors in the selection of suppliers of non-coffee food and beverage raw materials to make a Decision Support System Application (DSS) using the Simple Additive Weighting (SAW) method. DSS is a method used to support decision making using data, with an easy display for users, and involves the thoughts of decision makers. SAW is a method by calculating a weighted sum to rate all options and attributes. The results of this study show that the factors used in the selection of raw material suppliers are delivery speed, price, discount rate, service, warranty, product authenticity, payment term. In addition, a decision support system application is also produced which consists of a homepage menu, goods, suppliers, criteria, sub criteria, weights, ratings and results. This application can produce the best alternative recommendations according to the weight and value desired by Excelso Coffee Rinjani Semarang.
Pengaruh Dana Pihak Ketiga dan Biaya Operasional Pendapatan Operasional Terhadap Profitabilitas Pada Bank Umum Swasta
Authors: Trisnaningrum Sekar Adi , Debataraja Mintauli 
Published: June 2024

Tujuan dari penelitian ini yaitu untuk mengetahui pengaruh Dana Pihak Ketiga (DPK) dan Biaya Operasional Pendapatan Operasional (BOPO) terhadap Profitabilitas (ROA) pada Bank Umum Swasta yang terdaftar di Bursa Efek Indonesia (BEI). Pengambilan sampel dipilih menggunakan purposive sampling dengan hasil 28 Bank Umum Swasta. Data yang diteliti berupa data sekunder yang diperoleh dari laporan publikasi Bank Umum Swasta periode 2018-2022. Penelitian ini menggunakan metode pendekatan kuantitatif dengan metode analisis data yang digunakan yaitu uji asumsi klasik, analisis regresi linier berganda, dan uji hipotesis. Hasil penelitian ini membuktikan bahwa Dana Pihak Ketiga (DPK) tidak mempengaruhi Profitabilitas (ROA), sedangkan Biaya Operasional Pendapatan Operasional (BOPO) berpengaruh negatif terhadap Profitabilitas (ROA). Hasil secara simultan Dana Pihak Ketiga (DPK) dan Biaya Operasional Pendapatan Operasional (BOPO) mempengaruhi secara negatif terhadap Profitabilitas (ROA).
ESPACIALIDADE DA VIOLÊNCIA NO TERRITÓRIO URBANO
Authors: Dantas Régis Façanha 
Published: June 2024

Este trabalho relaciona a violência, o espaço territorial e suas vulnerabilidades locais através de um índice que revele essa relação espaço-temporal, buscando padrões espaciais. São referenciadas teorias da violência relacionadas com o espaço e vulnerabilidades. A metodologia usada foi a criação do Índice de Violência Espacial-IVE através da análise multivariada de componentes principais. Para averiguação das evidências, a análise exploratória de dados espaciais foi usada para descrever e visualizar padrões de associação (clusters espaciais) e sugerir relações no espaço entre as variáveis na cidade de Fortaleza, com dados de 2016 a 2018, período de maior violência. O resultado foi a verificação de evidências empíricas do IVE, demonstrando que os espaços dos setores agregados com seus níveis de violência se correlacionam espacialmente com áreas mais vulneráveis e com a desordem urbana. Com o IVE, é possível compatibilizar as políticas públicas com as características do espaço da violência, potencializando a eficiência das estratégias.
RESPON BEBERAPA GENOTIPE TANAMAN PADI GOGO LOKAL SUMATRA BARAT TERHADAP PEMBERIAN PUPUK ORGANIK CAIR PADA INCEPTISOL
Authors: Reda Abdul , Ediwirman Ediwirman , Ernita Milda , Jamilah Jamilah , Sunadi Sunadi 
Published: June 2024

Upland rice is a type of rice that has the potential to be developed in the South Solok area on Inceptisol dry land. Several types of upland rice were tested with the application of liquid organic fertilizer to obtain the best interaction between upland rice types and liquid organic fertilizer concentrations on growth and yield. The experiment was conducted on the inceptisol land of the Central Seed Center, South Solok District Agriculture Office, altitude of 980 meters above sea level, from July to December 2022. The experiment was arranged using a Randomized Block Design, a factorial treatment consisting of two factors. The first factor is the genotype of upland rice, namely; Guliang Tanda Merah, Rokan, Sibawang, and Simaritik. The second factor is the concentration of liquid organic fertilizer namely; 0, 20, 40, and 60 ml l-1, each experimental unit consisted of 3 replicates. observed data were analyzed using the F test if the calculated F is greater than the F table then proceed with the DNMRT test at the 5% level. Based on the experimental results, it can be concluded that the interaction of genotypes of upland rice and POC 20 ml.l 1 on the variable number of panicle grains. Provision of 60 ml.l-1 POC increased plant height growth, number of productive tillers, flowering age, harvest age, flag leaf length, number of panicles, panicle length, number of grains per hill, number of empty grains, number of grains per hill, percentage of empty grain, grain weight per hill of upland rice plants. upland rice genotype, Guliang Tandai Merah is a genotype that has high productivity in all observed variables
Structure and Photo-response Properties of FZO/ITO Thin Film
Authors: - Amrina Mustaqim , Lature Yeli Krisdayanti , Anrokhi Mohamad Samsul , Friansa Koko , Maharsi Retno , Nurfani Eka 
Published: June 2024

The structure and photo-response properties of ZnO:Fe/ITO thin film synthesized using a pyrolysis method were studied in this work. ZnO:Fe/ITO thin film referred to as FZO/ITO was characterized using the X-ray diffraction (XRD) technique and current-voltage (I-V) measurements. The XRD analysis showed that the detected peaks at 30.23°, 35.15°, 37.36°, 45.18°, and 50.54° belonged to the ITO cubic phase. The I-V analyses showed that the sample had the saturation current, Schottky barrier, and sensitivity of 16.24 µA, 0.4771, and 0,90 µA respectively. The FZO/ITO gave a good response toward the light.
Sintesis Karbon Aktif dari Tandan Kosong Kelapa Sawit dengan Aktivator Gelombang Mikro dan Pengujian Kualitas Berdasarkan SNI 06-3730-1995
Authors: Oktaviani Zeny , Wahyuni Dwiria , Nurhanisa Mega 
Published: June 2024

Karbon aktif merupakan jenis karbon berpori yang memilki daya serap tinggi terhadap zat yang ada di lingkungan karena telah diaktifkan. Limbah tandan kosong kelapa sawit (TKKS) yang jumlahnya cukup melimpah di Indonesia dapat dijadikan bahan pembuatan karbon aktif. Tujuan penelitian adalah menentukan pengaruh variasi daya dan waktu aktivasi menggunakan microwave pada efisiensi adsorpsi larutan metilen biru serta menyelidiki jika karbon aktif dari TKKS sesuai standar uji SNI 06-3730-1995. Adapun metode penelitian yang dilakukan yaitu tahap dehidrasi dilakukan dengan sinar matahari dan oven dengan suhu oven 110°C sampai massa tetap; tahap karbonisasi dilakukan dengan bantuan furnace selama 3 jam dengan suhu 500°C; dan tahap aktivasi menggunakan aktivasi gelombang mikro dengan variasi daya yaitu 500W, 600W, dan 900W dan variasi waktu yaitu 5, 10, dan 15 menit; serta dilakukan pengujian kualitas karbon aktif pada parameter tertentu yaitu kadar air, bagian yang menghilang saat pemanasan 950°C, karbon aktif murni, kadar abu, dan daya serap pada metilen biru. Hasil penelitian menunjukkan karbon aktif terbaik adalah pada aktivasi 600W selama 10 menit dengan pengujian kadar abu, kadar air, dan daya serap pada metilen biru sesuai syarat mutu SNI 06-3730-1995.
Correlation analysis between biomechanical characteristics of lower extremities during front roundhouse kick in Taekwondo and effective scores of electronic protectors
Authors: Jia Mengyao , Ma Yong , Huang Ruifeng , Liu Lin , Wang Zhaoyi , Lin Shijie , Peng Qian , Xiong Jun , Zheng Weitao 
Published: June 2024

Objective: The purpose of this study is to analyze the inherent relationship between the score values and the biomechanical characteristics of the forward kicking motion, we aim to identify the fundamental variables influencing the score values of the forward kicking motion and establish the key biomechanical factors that effectively trigger scoring in the forward kicking motion.Methods: The DaeDo electronic scoring system was used with the Vicon optical motion capture system and the Kistler 3D force platform to obtain kinematic and kinetic variables of the front roundhouse kick motion. Linear bivariate correlation analysis and principal component analysis were used to analyze the associations between kinematic, kinetic variables, and scoring values, and summarize key biomechanical factors for effectively scoring.Results: The peak ankle plantar flexion angle and knee extension torque of the kicking leg showed a significant negative correlation with scoring values (r &lt; 0, p &lt; 0.05), while other variables showed no statistical significance. The peak knee flexion angle and hip extension angular velocity of the supporting leg showed a significant positive correlation with scoring values (r &gt; 0, p &lt; 0.01), while the peak ankle plantar flexion torque showed a significant negative correlation with scoring values (r &lt; 0, p &lt; 0.05), and other variables showed no statistically significant correlation. The absolute values of eigenvectors of the first and second principal components, which included hip angular velocity, ankle angle, knee torque, and hip torque, were relatively large, indicating their strong influence on effective scoring triggering.Conclusion: Maintaining ankle dorsiflexion and a larger knee flexion angle in the kicking leg is favorable for triggering scoring. Higher knee flexion angle and hip extension angular velocity in the supporting leg are also advantageous for triggering scoring. “Body posture” and “Strength” are key factors that effectively trigger scoring.