bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluating the diagnostic performance of a large language model‐powered chatbot for providing immunohistochemistry recommendations in dermatopathology
Authors: McCrary Myles R. , Galambus Justine , Chen Wei‐Shen 
Published: May 2024

AbstractBackgroundLarge language model (LLM)‐powered chatbots such as ChatGPT have numerous applications. However, their effectiveness in dermatopathology has not been formally evaluated. Dermatopathological cases often require immunohistochemical workup. Here, we evaluate the performance of a chatbot in providing diagnostically useful information on immunohistochemistry relating to dermatological diseases.MethodsWe queried a commonly used chatbot for the immunophenotypes of 51 cutaneous diseases, including a diverse variety of epidermal, adnexal, hematolymphoid, and soft tissue entities. We requested it to provide references for each diagnosis. All tests were repeated, compiled, quantified, and then compared with established literature standards.ResultsClustering analysis demonstrated that recommendations correlated with tumor type, suggesting chatbots can supply appropriate panels. However, a significant portion of recommendations were factually incorrect (13.9%). Citations were rarely clinically useful (24.5%). Many were confabulated (27.2%). Prompt responses for cutaneous adnexal lesions tended to be less accurate while literature references were less useful. Reference retrieval performance was associated with the number of PubMed entries per entity.ConclusionsThis foundational study suggests that LLM‐powered chatbots may be useful for generating immunohistochemical panels for dermatologic diagnoses. However, specific performance capabilities and biases must be considered. In addition, extreme caution is advised regarding the tendencies to fabricate material. Future models intentionally fine‐tuned to augment diagnostic medicine may prove to be valuable.
Role of protein arginine methyltransferase 1 in obesity‐related metabolic disorders: Research progress and implications
Authors: Xuan Xiaolei , Zhang Yongjiao , Song Yufan , Zhang Bingyang , Liu Junjun , Liu Dong , Lu Sumei 
Published: May 2024

AbstractObesity has become a major global problem that significantly confers an increased risk of developing life‐threatening complications, including type 2 diabetes mellitus, fatty liver disease and cardiovascular diseases. Protein arginine methyltransferases (PRMTs) are enzymes that catalyse the methylation of target proteins. They are ubiquitous in eukaryotes and regulate transcription, splicing, cell metabolism and RNA biology. As a key, epigenetically modified enzyme, protein arginine methyltransferase 1 (PRMT1) is involved in obesity‐related metabolic processes, such as lipid metabolism, the insulin signalling pathway, energy balance and inflammation, and plays an important role in the pathology of obesity‐related metabolic disorders. This review summarizes recent research on the role of PRMT1 in obesity‐related metabolic disorders. The primary objective was to comprehensively elucidate the functional role and regulatory mechanisms of PRMT1. Moreover, this study attempts to review the pathogenesis of PRMT1‐mediated obesity‐related metabolic disorders, thereby offering pivotal information for further studies and clinical treatment.
Autism spectrum disorder identification using multi‐model deep ensemble classifier with transfer learning
Authors: Herath Lakmini , Meedeniya Dulani , Marasinghe Janaka , Weerasinghe Vajira , Tan Tele 
Published: May 2024

AbstractIdentifying autism spectrum disorder (ASD) symptoms accurately is a challenging task. The traditional subjective diagnostic process of ASD relies on time‐consuming behavioural and psychological observations. In this study, we introduce an ensemble learning‐based classification model using an open‐access database focusing on functional magnetic resonance imaging (fMRI). We propose a novel multi‐model ensemble classifier (MMEC) and multisite ensemble classifier (MSEC) with transfer learning (TL) for ASD classification to improve the prediction accuracy. The MMEC utilizes four base classifiers, Inception V3, ResNet50, MobileNet, and DenseNet to boost the performance of the individual convolutional neural network (CNN) models. The MSEC combined the base classifiers trained from different data sites. We evaluate the two models with ensemble averaging, weighted averaging, and stacking methods. The proposed MMEC with stacking shows the state of art performance compared to MSEC, improving the prediction accuracy by 3.25%. The obtained results have shown an accuracy of 97.82%, 97.82%, and 97.78% for ensemble averaging, weighted averaging, and stacking methods, respectively, on multi‐site datasets. The ensemble classifier MMEC performed better than a single classifier on the multi‐site dataset. The proposed MMEC opens a new paradigm to design a universal ASD classification framework.
Retrospective chart review of GI bleeding in people with von Willebrand disease
Authors: Roberts Jonathan C. , Escobar Miguel A. , Acharya Suchitra , Hwang Nina X. , Wang Michael , Hale Sarah , Brighton Sarah , Kouides Peter A. 
Published: May 2024

AbstractIntroductionGastrointestinal (GI) bleeding events (BEs) in von Willebrand disease (VWD) are difficult to diagnose and often recurrent. Limited data from clinical trials has led to lack of consensus on treatment options.AimDescribe current treatments and outcomes for GI BEs in people with VWD.MethodsThis retrospective, observational, multicentre chart review study was conducted from January 2018 through December 2019 and included patients with inherited VWD with ≥1 GI BE in the preceding 5 years. Baseline characteristics, number and aetiology of BEs, associated GI‐specific morbidities/lesions, treatment and outcomes were analysed descriptively.ResultsSixty bleeds were reported in 20 patients with type 1 (20%), type 2 (50%) and type 3 (30%) VWD. During the 5‐year study period, 31 (52%) BEs had one identified or suspected cause; multiple causes were reported in 11 (18%). Most GI BEs (72%) were treated with a combination of von Willebrand factor (VWF), antifibrinolytics and/or other haemostatic or non‐haemostatic treatments. Time to resolution did not differ by VWF treatment use; however, BEs treated with non‐VWF treatments tended to resolve later. In patients with GI‐specific morbidities/lesions, 84% resolved with first‐line treatment; time to resolution tended to be longer than in patients without such morbidities/lesions. Thirteen BEs occurred in patients receiving prophylaxis and 47 in patients receiving on‐demand treatment; 18 BEs resulted in a switch to prophylaxis after bleed resolution.ConclusionsThis study confirms the unmet need for the management of recurrent GI BEs in people with VWD and the need for prospective data, especially on prophylaxis.
Patterns of aerial arthropod biomass and diversity from three regions of boreal Alaska
Authors: Sikes Derek S. , Hagelin Julie C. , Skinner John P. , Haberski Adam , DuBour Kristin A. , Johnson James A. 
Published: May 2024

Abstract
Multi‐decadal monitoring has revealed dramatic evidence of global decline in arthropod biomass and biodiversity, yet little baseline information exists for Alaska, a region 1/5th the size of the contiguous US states.
We documented patterns of aerial arthropod biomass and diversity in a multi‐year investigation of three regions in boreal Alaska—two in central Alaska (Fairbanks and Tetlin) and one in southcentral Alaska (Anchorage). Sampling employed canopy Malaise and near‐ground pollinator traps as part of a parallel study of a steeply declining songbird. Traps yielded 115,078 specimens of 15 orders and 692 unique taxa with body sizes ≥3 mm.
During peak summer (15 June–15 July), mean aerial arthropod biomass was more than three times higher in traps in Fairbanks (50.6 mg·d−1, confidence interval [CI]: 34.5–63.7) than Anchorage (15.8 mg·d−1, CI: 9.3–26.4). Tetlin exhibited an intermediate value (35.4 mg·d−1, CI: 18.4–67.4). Temperature correlated positively with captured biomass, whereas wind (above 1.5 m·s−1) correlated negatively.
To obtain species‐level diversity data, we focused on beetles, representing a wide range of feeding guilds and taxa. Beetles accounted for 6229 adult specimens, 364 unique (mostly species‐level) taxa and 47 families. Trophic categorizations of beetles were similar for the central Alaskan sites; both had a greater proportion of wood‐feeding beetles than Anchorage. Ten species are potentially new to science and 49 are new state records for Alaska.
Our work provides the first insight into regional differences and seasonal trends in aerial arthropod biomass and diversity in boreal Alaska, creating important baselines for the future.
End of 2022/23 Season Influenza Vaccine Effectiveness in Primary Care in Great Britain
Authors: Whitaker Heather J. , Willam Naoma , Cottrell Simon , Goudie Rosalind , Andrews Nick , Evans Josie , Moore Catherine , Agrawal Utkarsh , Hassell Katie , Gunson Rory , Zitha Jana , Anand Sneha , Sebastian‐Pillai Praveen , Kalapotharakou Panoraia , Okusi Cecilia , Hoschler Katja , Jamie Gavin , Kele Beatrix , Hamilton Mark , Couzens Anastasia , Quinot Catherine , Pheasant Kathleen , Byford Rachel , Marsh Kimberly , Robertson Chris , de Lusignan Simon , Williams Christopher , Zambon Maria , McMenamin Jim , Watson Conall H. 
Published: May 2024

ABSTRACTBackgroundThe 2022/23 influenza season in the United Kingdom saw the return of influenza to prepandemic levels following two seasons with low influenza activity. The early season was dominated by A(H3N2), with cocirculation of A(H1N1), reaching a peak late December 2022, while influenza B circulated at low levels during the latter part of the season. From September to March 2022/23, influenza vaccines were offered, free of charge, to all aged 2–13 (and 14–15 in Scotland and Wales), adults up to 49 years of age with clinical risk conditions and adults aged 50 and above across the mainland United Kingdom.MethodsEnd‐of‐season adjusted vaccine effectiveness (VE) estimates against sentinel primary‐care attendance for influenza‐like illness, where influenza infection was laboratory confirmed, were calculated using the test negative design, adjusting for potential confounders.MethodsResults In the mainland United Kingdom, end‐of‐season VE against all laboratory‐confirmed influenza for all those > 65 years of age, most of whom received adjuvanted quadrivalent vaccines, was 30% (95% CI: −6% to 54%). VE for those aged 18–64, who largely received cell‐based vaccines, was 47% (95% CI: 37%–56%). Overall VE for 2–17 year olds, predominantly receiving live attenuated vaccines, was 66% (95% CI: 53%–76%).ConclusionThe paper provides evidence of moderate influenza VE in 2022/23.
Effects of temperature inversion on densification in chemical vapor infiltration
Authors: Ramanuj Vimal , Li Mengnan , Ge Wenjun , Sankaran Ramanan , She Ying , Dardas Zissis 
Published: May 2024

AbstractIn a classical chemical vapor infiltration (CVI) process, the competing effects of chemical kinetics and reagent gas transport lead to non‐uniform depositions such that outer layers of a preform densify faster leaving the core highly porous. Currently, CVI must be performed at a sufficiently low temperature to achieve good densification quality which leads to high processing time and cost. Volumetric heating of the preform, especially through microwaves, can create temperature inversion such that the core is hotter than the outer surface and potentially, overcome the challenges associated with isothermal CVI. Direct numerical simulations (DNS) of densification under various such temperature distributions indicate that microwave heating in CVI processing can lead to better (uniform) densification of porous preforms. The role of key parameters describing the temperature distributions on the densification behavior is investigated. Strategic temporal control of the temperature distribution shows that processing times can be reduced by almost half while maintaining a good densification quality similar to that of low‐temperature isothermal processing. Inside‐out densification due to the inverted temperature profile is a key distinguishing characteristic of microwave assisted CVI.
Feasibility research of perovskite‐type PrAlO3+δ as high‐temperature infrared radiation coating
Authors: Xu Mingyi , Chen Wenbo , Lü Kaiyue , Huang Yan , Deng Longhui , Jiang Jianing , Dong Shujuan , Cao Xueqiang , Lu Guoqiang , Zhang Yixing 
Published: May 2024

AbstractThermal radiation coating with low thermal conductivity and high infrared emissivity are desirable. In this work, a novel rare‐earth aluminate (PrAlO3+δ with rhombohedral structure) was synthesized via solid‐state reaction method, and the corresponding coating was fabricated using atmospheric plasma spraying (APS). The study encompassed an investigation into the phase structure, high‐temperature phase stability, thermo‐mechanical characteristics, and infrared properties. The results illustrate that as‐deposited coating contained amorphous phase, but recrystallized coating presented phase stability up to 1600°C. Furthermore, the recrystallized coating exhibited low thermal conductivity of 1.35 W/m K at 900°C as well as an average coefficient of thermal expansion of 10.36 × 10−6/K. Also, the coating exhibited high infrared emissivity related to high valance state (Pr4+) and oxygen vacancies. And the average infrared emissivity within 2–14 µm was 0.822 at 1300°C and presented slight decrease with the increase of temperature (the average infrared emissivity of 0.795 at 1800°C).
Antecubital vein combined with femoral vein pathway could shorten the learning curve of simultaneous bilateral adrenal vein sampling
Authors: Liu Jiaqi , Shao Shuai , Wang Qiuli , Zhang Zhiping , Ding Xiaoying , Zhao Li , Wang Jinliang , Ji Xiaohong , Dai Qiuyan , Du Mingli , Zhang Zhi 
Published: May 2024

AbstractDuring our previous bilateral adrenal vein sampling (AVS) procedure, the authors observed that accessing the left adrenal vein through the antecubital vein was more feasible than the conventional femoral vein. Meanwhile, the femoral vein pathway facilitated access to the right adrenal vein than the antecubital vein pathway. Therefore, the authors hypothesized that simultaneous bilateral AVS via the antecubital combined with the femoral vein pathway could improve the success rate. A total of 94 cases of AVS via the antecubital combined with the femoral vein pathway were performed, while the remaining 20 cases employed the antecubital vein pathway at our center between August 2020 and April 2023. Furthermore, a meta‐analysis was conducted in this study using 15 selected articles to determine the success rate of AVS in each center and pathway. The success rate of ACTH‐stimulated simultaneous bilateral AVS via the antecubital vein combined with the femoral vein pathway was 92.85% (P = .503) on the right and 95.00% (P < .001) on the left. In the antecubital vein pathway, the success rates were only 25.00% (P < .001) on the right side and 80.00% (P = .289) on the left side. The results of meta‐analysis demonstrated a success rate of 78.16% on the right and 94.98% on the left for ACTH‐stimulated AVS via the femoral vein pathway. Based on our center's experience, simultaneous bilateral adrenal vein sampling via the combined pathway could improve the success rate of AVS in the short term and shorten the learning curve.
Predictive value of Systematic Coronary Risk Evaluation 2‐Diabetes risk model and arterial stiffness for cardiovascular events in the Asian population with type 2 diabetes mellitus
Authors: Suwannasom Pannipa , Thonghong Tasalak , Leemasawat Krit , Nantsupawat Teerapat , Prasertwitayakij Narawudt , Pairoj Chutamas , Wongcharoen Wanwarang , Phrommintikul Arintaya ,   CORE‐Thailand Investigators
Published: May 2024

AbstractAims/IntroductionIndividuals with diabetes are at high risk of developing cardiovascular events. The present study investigated the predictive value of the cardio‐ankle vascular index (CAVI) when added to the Systematic Coronary Risk Evaluation 2‐Diabetes (SCORE2‐Diabetes) risk algorithm to predict cardiovascular events in the Asian population.Materials and MethodsThe SCORE2‐Diabetes risk was assessed in 1,502 patients with diabetes, aged 40–69 years. Then, we further stratified each 10‐year risk category with a CAVI value of 9.0. The primary outcomes (composite of all causes of death, myocardial infarction, stroke and hospitalization for heart failure) were assessed over 5 years.ResultsThe mean age of the population was 59.8 ± 6.4 years. The proportion of 10‐year risk according to the SCORE2‐Diabetes risk of low, moderate, high and very high risk identified at 7.2, 30.0, 27.2 and 35.6%, respectively. The mean CAVI value was 8.4 ± 1.4, and approximately 35.4% of the patients had CAVI ≥9.0. The SCORE2‐Diabetes risk algorithm independently predicted the primary outcomes in patients with diabetes (hazard ratio 1.18, 95% confidence interval [CI] 1.13–1.22), whereas CAVI did not (hazard ratio 1.03, 95% CI 0.89–1.18). The C‐index for the primary outcomes of the SCORE2‐Diabetes risk algorithm alone was 0.72 (95% CI 0.67–0.77). The combination of SCORE2‐Diabetes and CAVI, both in the continuous value and risk groups, did not improve discrimination (C‐index 0.72, 95% CI 0.67–0.77 and 0.68, 95% CI 0.64–0.74, respectively).ConclusionsAdding the CAVI to the SCORE2‐Diabetes risk algorithm did not improve individual risk stratification in patients with diabetes.
The impact of different surface treatments on repair bond strength of conventionally, subtractive‐, and additive‐manufactured denture bases
Authors: Sahin Zeynep , Ozer Nazire Esra , Akan Tamer , Kılıcarslan Mehmet Ali , Karaagaclıoglu Lale 
Published: May 2024

AbstractObjectiveThis study aimed to examine the shear bond strength (SBS) of repair material to conventionally, subtractive‐, and additive‐manufactured denture bases after different surface treatments.Materials and MethodsDisk‐shaped test specimens (N = 300) were prepared from denture base materials produced by one conventional (Procryla), one subtractive (Yamahachi), and one additive (Curo Denture) method. The test specimens were randomly divided into five groups (n = 10) and exposed to a variety of surface treatments—Group A: no surface treatment; Group B: grinding with silicon carbide paper; Group C: sandblasting; Group D: erbium: yttrium‐aluminum‐garnet laser; and Group E: plasma. Repair was performed with autopolymerizing acrylic resin (Meliodent). Surface roughness analyses were performed with a profilometer. Scanning electron microscopy was used to examine one specimen from each subgroup. SBS was evaluated on a universal testing machine. Failure types were observed under a stereomicroscope.ResultsSurface roughness values were significantly higher in all test materials in Group D than in the other groups (p < 0.001). For conventional resin, the SBS values were higher in Group C than in Groups A, D, and E (p < 0.001). For CAD/CAM material, Groups B and C had significantly greater SBS increases compared with Group E (p < 0.001). For 3D material, Group D showed higher SBS than all groups except Group C (p < 0.001).ConclusionsFor SBS, sandblasting was most effective in the conventional group, whereas laser treatment was the most effective in the additive‐manufactured group. For the subtractive group, surface treatments other than plasma exhibited similar SBS.Clinical SignificanceIn repairing fractured prostheses, any degree of roughening suitable for the material content may provide an SBS benefit.
Building momentum through networks: Bioimaging across the Americas
Authors: De Niz Mariana , Escobedo García Rodrigo , Terán Ramirez Celina , Pakowski Ysa , Abonza Yuriney , Bialy Nikki , Orr Vanessa L. , Olivera Andres , Abonza Victor , Alleva Karina , Allodi Silvana , Almeida Michael F. , Becerril Cuevas Alexis Ricardo , Bonnet Frederic , Burgos Solorio Armando , Chew Teng‐Leong , Chiabrando Gustavo , Cimini Beth , Cleret‐Buhot Aurélie , Contreras Jiménez Gastón , Daza Laura , De Sá Vanessa , De Val Natalia , Delgado‐Álvarez Diego L. , Eliceiri Kevin , Fiolka Reto , Grecco Hernan , Hanein Dorit , Hernández Herrera Paúl , Hockberger Phil , Hernandez Haydee O. , Hernandez Guadarrama Yael , Itano Michelle , Jacobs Caron A. , Jiménez‐García Luis F. , Jiménez Sabinina Vilma , Kamaid Andres , Keppler Antje , Kumar Abhishek , Lacoste Judith , Lovy Alenka , Luby‐Phelps Kate , Mahadevan‐Jansen Anita , Malacrida Leonel , Mehta Shalin B. , Miller Caroline , Miranda Kildare , Moore Joshua A. , North Alison , O'Toole Peter , Olivares Urbano Mariana , Pietrasanta Lía I. , Portugal Rodrigo V. , Rossi Andrés H. , Sanchez Contreras Jonathan , Strambio‐De‐Castilla Caterina , Soldevila Gloria , Vale Bruno , Vazquez Diana , Wood Chris , Brown Claire M. , Guerrero Adan 
Published: May 2024

AbstractIn September 2023, the two largest bioimaging networks in the Americas, Latin America Bioimaging (LABI) and BioImaging North America (BINA), came together during a 1‐week meeting in Mexico. This meeting provided opportunities for participants to interact closely with decision‐makers from imaging core facilities across the Americas. The meeting was held in a hybrid format and attended in‐person by imaging scientists from across the Americas, including Canada, the United States, Mexico, Colombia, Peru, Argentina, Chile, Brazil and Uruguay. The aims of the meeting were to discuss progress achieved over the past year, to foster networking and collaborative efforts among members of both communities, to bring together key members of the international imaging community to promote the exchange of experience and expertise, to engage with industry partners, and to establish future directions within each individual network, as well as common goals. This meeting report summarises the discussions exchanged, the achievements shared, and the goals set during the LABIxBINA2023: Bioimaging across the Americas meeting.
Congenital metastatic neuroblastoma with placental involvement as a rare cause of non‐immune fetal hydrops
Authors: Campillo‐Ajenjo Marta , Pena‐Burgos Eva Manuela , Herrero Ruiz Beatriz , Escuer Albero Guillermo , Rubio Aparicio Pedro , Parrón Pajares Manuel , Bret Zurita Montserrat , Regojo‐Zapata Rita María , Bartha Rasero José Luis , Antolín Alvarado Eugenia 
Published: May 2024

AbstractNon‐immune hydrops fetalis represents the end‐stage status of a variety of diseases, including metastatic tumors. We report a case of non‐immune hydrops fetalis associated with multiple disseminated echogenic nodular lesions detected by ultrasound and confirmed by magnetic resonance. Cordocentesis demonstrated anemia and thrombopenia. Differential diagnosis included histiocytosis X, acute leukemia or metastatic disease. A stillbirth was diagnosed at week 25 + 6. The autopsy revealed hydrops fetalis, a right adrenal gland mass, multiple disseminated nodules histologically composed of small round blue cells positive for synaptophysin, and placental involvement, concordant findings with congenital undifferentiated neuroblastoma Stage M. No chromosomal abnormalities were associated, nor amplification abnormalities in MYCN and ALK genes. Metastatic neuroblastoma should be considered in the differential diagnosis of non‐immune hydrops fetalis associated with multiple nodular lesions.