bluuebunny/crossref_metadata_2025_split huggingface dataset:
Emerging Natural Therapies for the Treatment of Inflammatory Bowel
Disease
Authors: Joshi Monika , Pandey Manju , Shankar Ravi , Ved Akash 
Published: May 2024

Abstract:
The term "inflammatory bowel disease," which includes Crohn's disease (CD) and
ulcerative colitis (UC), refers to a chronic inflammatory condition of the digestive system. There
are many different treatment options, such as corticosteroids, biologics, 5-aminosalicylate, and
immune-suppressants, but none of them can maintain the disease remission for a longer period,
which is the ultimate goal of treatment. Furthermore, they have numerous serious side effects
like nephrotoxicity, infertility, congestive heart failure, myopathy, etc. So, in order to treat these
conditions, researchers are concentrating more on natural medicine that is less expensive and has
fewer side effects. The current analysis includes a list of plants showing promising activity
against IBD. These include Cannabis sativa, Aloe vera, Boswellia serrata, Withania somnifera,
Curcuma longa, Triticum aestivum, and many others. These plants need to be further investigated in terms of preclinical and clinical studies to obtain the safety and efficacy data necessary for
their commercialisation. Global regulatory norms will facilitate simple commercialisation. Also,
more investigation is required to pinpoint the precise mechanism of action to confirm clinical
success.
Nanotechnology-Powered Meningitis Therapies: Lipid Nanoparticles Lead the Way
Authors: Karati Dipanjan , Mukherjee Swarupananda , Paul Susmita , Das Suchana , Prajapati Bhupendra , Patel Ravish J. , Jha Sajal Kumar 
Published: May 2024

Abstract:
The meninges serve as a protective layer, and the fluid around the brain and spinal
cord can become inflamed, known as meningitis. Lipid-based pharmaceutical formulations, by
their high lipophilicity, can negotiate the Blood-Brain Barrier (BBB). The current mode of
treatment of meningitis is mainly through antibiotics, which, at best, is partially effective. The
success of antibiotic therapy depends on several factors, for example, the difficulty of reaching
the infection site, maintaining proper concentrations of the drug after crossing the BBB, and
finally, its efficacy in preventing recurrent infection. In this context, interest has focused on organic
and inorganic nanostructures for meningitis and transporting antibiotics to the selected
region through the BBB. A focus has also been placed on several polymeric nanotechnology
techniques for detecting various types of meningitis. This review focuses on nano interventions
and their most recent meningitis treatments using nanotechnology.
Fisetin from Dietary Supplement to a Drug Candidate: An Assessment of
Potential - A Review
Authors: Mirza Mohd. Aamir , Padhi Santwana , Mohapatra Sradhanjali , Mahmood Syed , Iqbal Zeenat 
Published: May 2024

Abstract:
Fisetin is a bioactive compound found in numerous fruits and vegetables, including
strawberries, apples, grapes, persimmon, cucumber, onion, etc. The compound is also wellknown for its neurotrophic, anti-inflammatory, anti-carcinogenic, anti-diabetic, and other healthpromoting properties. Although there is increasing agreement that it has therapeutic properties,
its poor water solubility, high lipophilicity, and lower oral bioavailability make it difficult to use
clinically. Extensive research has attempted to overcome these restrictions by developing novel,
superior delivery systems. Considering the diverse potential, this review is the first to summarise
the available data on Fisetin to collate the information related to analytical methods, pharmacological action, their mechanisms, regulatory aspects, and toxicity profile. It also covers the marketed products, their related clinical trials, and patent updates of the moiety. In addition, an endeavor has been attempted to discuss and assess the various drug delivery systems employed to
increase the biological attributes of Fisetin. The presented manuscript is the first to present a
compendium of up-to-date literature on all of the domains considered necessary for this type of
natural molecule to carve down its path from being a mere dietary supplement to a promising
therapeutic drug candidate. The manuscript will definitely benefit the researchers working on
natural and bioactive compounds, industrial scientists, and the general population interested in
Fesitin as a dietary supplement.
Therapeutic Effects of Melatonin in the Regulation of Ferroptosis: A
Review of Current Evidence
Authors: Pourhanifeh Mohammad Hossein , Hosseinzadeh Azam , Koosha Fereshteh , Reiter Russel J. , Mehrzadi Saeed 
Published: May 2024

:
Ferroptosis is implicated in the pathogenesis of multiple diseases, including neurodegenerative
diseases, cardiovascular diseases, kidney pathologies, ischemia-reperfusion injury, and
cancer. The current review article highlights the involvement of ferroptosis in traumatic brain injury,
acute kidney damage, ethanol-induced liver injury, and PM2.5-induced lung injury. Melatonin,
a molecule produced by the pineal gland and many other organs, is well known for its anti-
aging, anti-inflammatory, and anticancer properties and is used in the treatment of different diseases.
Melatonin's ability to activate anti-ferroptosis pathways including sirtuin (SIRT)6/p- nuclear
factor erythroid 2-related factor 2 (Nrf2), Nrf2/ antioxidant responsive element (ARE)/ heme
oxygenase (HO-1)/SLC7A11/glutathione peroxidase (GPX4)/ prostaglandin-endoperoxide synthase
2 (PTGS2), extracellular signal-regulated kinase (ERK)/Nrf2, ferroportin (FPN), Hippo/
Yes-associated protein (YAP), Phosphoinositide 3-kinase (PI3K)/ protein kinase B (AKT)/ mammalian
target of rapamycin (mTOR) and SIRT6/ nuclear receptor coactivator 4 (NCOA4)/ ferritin
heavy chain 1 (FTH1) signaling pathways suggests that it could serve as a valuable therapeutic
agent for preventing cell death associated with ferroptosis in various diseases. Further research is
needed to fully understand the precise mechanisms by which melatonin regulates ferroptosis and
its potential as a therapeutic target.
Nano-nutraceuticals to Combat Oxidative Stress: Unlocking Newer
Paradigms in Adjuvant Therapy
Authors: Pooja  , Pandey Manisha , Kumar Tarun , Goswami Harsh , Kumari Rasna , Kumari Shivani , Jain Neha , Gorain Bapi , Maurya Pawan Kumar , Chawla Viney , Chawla Pooja A. 
Published: May 2024

Abstract:
Nutraceuticals are products that provide both nutritional and therapeutic benefits. These
compounds can slow the aging process and provide physiological effects shielding individuals
from acute and chronic diseases. People's interests have shifted from allopathic to Ayurvedic to nutraceuticals
in recent years. These are often common dietary supplements that have drawn customers
worldwide because of their high nutritional safety and lack of adverse effects when used
for a long time. Although conventional dosage forms, including pills, tablets, and semi-solids, are
still available, they nevertheless have poorer bioavailability, less stability, and less effectiveness
for targeted delivery of bioactives. The use of effective nanocomplex systems as nano-antioxidants
using nanotechnology has become a promising field. Among its many uses, nanotechnology
is mostly used to create foods and nutraceuticals that are more bioavailable, less toxic, and more
sustainable. Additionally, it has been emphasized how precisely nano-pharmaceuticals for oxidative
stress produce the desired effects. These improvements show improved antioxidant delivery
to the target region, reduced leakage, and increased targeting precision. The outcomes demonstrated
that oxidative stress-related illnesses can be effectively treated by lowering ROS levels with
the use of nanonutraceuticals. The major ideas and uses of nano-nutraceuticals for health are outlined
in this review, with an emphasis on reducing oxidative stress.
Nature's Pharmacy: Herbal Interventions in Rheumatoid Arthritis
Treatment: A Comprehensive Review
Authors: Mittal Vishnu , Barak Ashima , Sharma Anjali , Singhal Abhinav 
Published: May 2024

Abstract:
Rheumatoid Arthritis (RA) is an inflammatory disease that causes severe joint destruction and persistent inflammation. This review aims to evaluate the efficacy, safety, and mechanisms of action of various herbal interventions in managing RA, providing valuable insights for
patients and healthcare practitioners. To investigate the anti-inflammatory and antioxidant properties of selected herbal interventions, including turmeric, ginger, Boswellia serrata (frankincense),
green tea, and Ashwagandha, to assess their potential as complementary treatments for RA, a comprehensive analysis is performed on the anti-inflammatory mechanisms and antioxidant effects of
selected herbs. Emphasis is placed on the modulation of key inflammatory pathways and their ability to counteract oxidative stress, which are crucial factors in RA progression. Safety profiles and
potential adverse effects of herbal remedies are also scrutinized. The review reveals promising evidence supporting the efficacy of turmeric and ginger in alleviating RA symptoms by modulating
inflammatory pathways. Additionally, Boswellia serrata shows potential as an adjunct therapy for
joint health and inflammation. The antioxidant-rich properties of green tea and Ashwagandha are
highlighted, suggesting their role in counteracting oxidative stress associated with RA. In conclusion, while herbal remedies like turmeric, ginger, Boswellia serrata, green tea, and Ashwagandha
offer potential complementary treatments for RA, their safety profiles and adverse effects warrant
careful consideration. Rigorous clinical trials are needed to confirm their efficacy and safety, highlighting the necessity for further research in this area. These findings are crucial for patients and
healthcare providers in making informed decisions about incorporating herbal interventions into
RA treatment strategies.
Pulmonary Hypertension Related to Left Heart Disease (PH-LHD)
Authors: Geft Dael R. , Hage Antoine 
Published: May 2024

Abstract:
Pulmonary Hypertension secondary to left heart disease (PH-LHD) is the most common
form of pulmonary hypertension (PH) and is a frequent complication of heart failure. It is associated
with increased morbidity and mortality. The definitions of both PH and PH-LHD have
changed over time and now generally follow those established by the 6th World Symposium on
Pulmonary Hypertension (WSPH) in 2018 and the most recent European Society of Cardiology
(ESC) guidelines in 2022. A systematic approach including clinical history and noninvasive testing
is required to properly diagnose PH-LHD, and accurate hemodynamics by right heart catheterization,
sometimes involving provocative testing, are often needed to diagnose PH-LHD but are essential
to further subclassify PH-LHD into either isolated post-capillary pulmonary hypertension
(Ipc-PH) versus combined pre and post-capillary pulmonary hypertension (Cpc-PH). This distinction
is important as it guides therapeutic decisions and carries prognostic implications. Cpc-PH, in
particular, shares some histo-pathologic and hemodynamic characteristics with pulmonary arterial
hypertension (PAH) and, hence, the rationale for the potential use of pulmonary vasodilator therapy.
To date, however, there is no strong evidence to support PAH-specific medications for Cpc-
PH, and the mainstay of treatment for PH-LHD remains to treat the underlying cause of LHD. Further
research is warranted to refine therapeutic approaches, improve long-term outcomes, and explore
novel treatment modalities to alleviate the burden of PH in this patient population.
Is Low-free Triiodothyronine (fT3) Associated with Increased Morbidity in Patients Admitted to Coronary Care Units?
Authors: Akkus Oguz , Sen Fatih , Yasdıbas Ramazan , Otegen Alper Tunga , Huzmeli Irem , Akkus Gamze 
Published: May 2024

Background:
The effects of thyroid hormone on patients hospitalized in coronary
intensive care units are still controversial.
Objective: We retrospectively examined thyroid

Methods:
A total of 208 (Female/Male; 46.6%/53.4%) patients without any history of thyroid
disease were enrolled and screened. Patients with specific heart disease and existing thyroid hormone
parameters were included in the study. Low triiodothyronine syndrome is characterized by
reduced serum total or free T3 (fT3) concentrations in normal free T4 (fT4) and TSH levels.

Results:
The common diagnosis of the patients in the coronary care unit is acute coronary syndrome
(n = 59, 28.2 %) and heart failure (n = 46, 23.3%). Patients were divided into two groups
according to left ventricular ejection fraction percentages (LVEF ≤39% vs LVEF ≥40%). Plasma
fT3 levels were significantly correlated with low LVEF (≤39%) (p =0.002). fT3 (r = -0.183,
p =0.013) and hospitalization etiology (r = -0.161, p =0.023) were also the most critical parameters
affecting the length of hospitalization

Conclusion:
Low fT3 was associated with reduced ejection fraction and prolonged hospitalization,
which may lead to potential morbidities in HF patients and may be useful in risk stratification
and treatment strategies.
Assessment of Risky Riding Behaviors Using the Motorcycle Rider Behavior Questionnaire (MRBQ) among University Students
Authors: Setyowati Dina Lusiana , Setyaningsih Yuliani , Suryawati Chriswardani , Lestantyo Daru 
Published: May 2024

Background
Riding behavior is a significant factor in 90% of traffic accidents, with 43% of these accidents involving motorcyclists aged between 5 and 29 years. These accidents often result in severe injuries and fatalities; therefore, a study on risky riding behavior is necessary.

Objective
This research aimed to identify risky riding behavior among university students using the motorcycle rider behavior questionnaire (MRBQ).

Methods
A cross-sectional quantitative survey was conducted on students from 12 faculties at the State University in Semarang City, Central Java, Indonesia, in June, 2023. Data were collected via an online questionnaire, with a final analysis conducted on 37 participants. The chi-square test with a 95% confidence interval was used for data analysis.

Results
The results showed that traffic violation in the last 12 months was related to risky riding behavior (p = 0.057, RP = 0.671; 95% CI = 0.389-1.159), while gender, driver's license ownership, history of accidents reported to the police, and driving frequency were unrelated to risky riding behavior.

Conclusion
The research provides valuable insights into the factors that influence driving behavior. It underscores the importance of safety records and the potential impact of recent traffic violations on driving behavior. Public education, risk communication, and promoting safe behavior through positive modeling can help reduce accidents and foster a safer road culture.
Hierarchical Interdependency Blockchain for Assessing Performance and Modulation Proof of Stake (POS) Security Protocol in Healthcare
Application 5.0
Authors: V. Maheshwari , M. Prasanna 
Published: May 2024

Introduction:
Patients’ electronic health records (EHRs) stored in the cloud are more
likely to suffer from data breaches. Data security risks arise from EHRs relying on centralised databases,
as this approach places the responsibility for data protection on the user. Indeed, it leaves
data security to a single organisation, leaving it open to intrusion by its workers. Maintaining the
privacy and integrity of patient information is of utmost importance when interacting with and
integrating with EHR systems.

Method:
Therefore, in order to find the best blockchain framework for trustworthy electronic
health records (EHRs), a precise method for comparing the effects of several current blockchain
systems is required. Data from electronic health record applications is encrypted and saved in the
cloud using IPFS off-chain as part of this study, following a design that is consistent with patient
data management. To secure electronic health record data, the system uses a hierarchical interdependency
approach for block construction and framework design.

Result:
This research is focused on finding a solution to the issue of privacy leaking in data sharing.
To ensure the privacy of user’s data, the healthcare system utilises a multilevel authentication
mechanism and an encryption technique that is based on hierarchical interdependency attributes.
Smart contracts have been used to establish hierarchical access control for various Internet
of Things systems, guaranteeing control over data access. This paper describes how the system's
scalability, transaction latency, and throughput may be improved by implementing a modified
proof-of-stake (POS) security protocol in healthcare application 5.0. This helps to secure users'
privacy and security.

Conclusion:
In comparison to more conventional blockchain solutions, the experimental results
demonstrate improvements in efficiency and security in terms of variables such as block size,
upload time, transaction range, and evaluation metrics such as transaction delay.

result:
In addition, a generic EHR configuration strengthens the hierarchical interdependency blockchain. The results of this configuration are thoroughly discussed in the paper, revealing a noticeable improvement in the performance parameters block size, different nodes, upload time, transaction range, and evaluation metrics like Transaction delay, which are determined through empirical research for different EHR dataset scenarios of EHR blockchains
Gold Nanoparticle Synthesis and its Mode of Action as an Effective Therapy against Breast Carcinoma: Analysis of Traditional Methods and their Comparison with New Methods
Authors: Nawaz Yasir , Munir Saba , Tanvir Fouzia , Umar Asma , Majeed Imran , Hussain Ibrar , Nawaz Aqeela , Sadiqa Ayesha , Riaz Samreen , Rehman Samiya , Luqman Muhammad , Ali Ahmad , Zafar Javaria 
Published: May 2024

Abstract:
Breast cancer is one of the most widespread and lethal malignancies afflicting females
globally. The global incidence of breast cancer is on the rise, with an anticipated 4.4 million cases
by 2070. Notably, breast cancer constitutes approximately 25% of all cancer diagnoses. In the
realm of biomedical sciences, nanotechnology has ushered in a transformative era, particularly in
cancer therapy and diagnostics. Nanoparticles offer the capability to tailor specific sizes, with elevated
surface-to-volume ratios proving advantageous for drug distribution by ensuring a substantial
medicines loading volume. Gold nanoparticles exhibit a remarkable selectivity for cancer
cells, primarily attributed to the heightened permeability and retaining effects. This study aims to
assess the effectiveness of gold nanoparticles in breast cancer therapy, comparing them with traditional
techniques from previous research and elucidating their mechanism of action. Data for analysis
were sourced from various platforms, including Web of Science and Google Scholar, comprising
previously published information. Analysis revealed that historical studies employed conventional
techniques for breast cancer therapy. However, contemporary approaches now favor
nanomedicine, incorporating diverse drugs and delivery systems, surpassing traditional methods.
In summary, nanomedicine emerges as an exceptionally effective mode of breast cancer treatment
when juxtaposed with conventional approaches. Previous research also underscores the efficacy of
gold nanoparticles as a viable treatment modality. Currently, a spectrum of nanomedicines, including
gold nanoparticles, serves as a promising avenue for suppressing tumor development in breast
cancer patients
Assessing the Utility, Impact, and Adoption Challenges of an Artificial Intelligence–Enabled Prescription Advisory Tool for Type 2 Diabetes Management: Qualitative Study
Authors: Yoon Sungwon , Goh Hendra , Lee Phong Ching , Tan Hong Chang , Teh Ming Ming , Lim Dawn Shao Ting , Kwee Ann , Suresh Chandran , Carmody David , Swee Du Soon , Tan Sarah Ying Tse , Wong Andy Jun-Wei , Choo Charlotte Hui-Min , Wee Zongwen , Bee Yong Mong 
Published: May 2024

Background
The clinical management of type 2 diabetes mellitus (T2DM) presents a significant challenge due to the constantly evolving clinical practice guidelines and growing array of drug classes available. Evidence suggests that artificial intelligence (AI)–enabled clinical decision support systems (CDSSs) have proven to be effective in assisting clinicians with informed decision-making. Despite the merits of AI-driven CDSSs, a significant research gap exists concerning the early-stage implementation and adoption of AI-enabled CDSSs in T2DM management.

Objective
This study aimed to explore the perspectives of clinicians on the use and impact of the AI-enabled Prescription Advisory (APA) tool, developed using a multi-institution diabetes registry and implemented in specialist endocrinology clinics, and the challenges to its adoption and application.

Methods
We conducted focus group discussions using a semistructured interview guide with purposively selected endocrinologists from a tertiary hospital. The focus group discussions were audio-recorded and transcribed verbatim. Data were thematically analyzed.

Results
A total of 13 clinicians participated in 4 focus group discussions. Our findings suggest that the APA tool offered several useful features to assist clinicians in effectively managing T2DM. Specifically, clinicians viewed the AI-generated medication alterations as a good knowledge resource in supporting the clinician’s decision-making on drug modifications at the point of care, particularly for patients with comorbidities. The complication risk prediction was seen as positively impacting patient care by facilitating early doctor-patient communication and initiating prompt clinical responses. However, the interpretability of the risk scores, concerns about overreliance and automation bias, and issues surrounding accountability and liability hindered the adoption of the APA tool in clinical practice.

Conclusions
Although the APA tool holds great potential as a valuable resource for improving patient care, further efforts are required to address clinicians’ concerns and improve the tool’s acceptance and applicability in relevant contexts.
Attention-deficit/hyperactivity disorder: clinical phenotypes, polymorphism of life-course manifestations, and therapeutic strategies
Authors: Martsenkovsky I. , Martsenkovska I. , Makarenko H. 
Published: May 2024

Attention-deficit/hyperactivity disorder (ADHD) is a common neurobehavioral disorder that manifests in childhood and persists into adulthood. The prevalence of ADHD (USA/worldwide) in children and adolescents is 9.5/5.29 %, in adults — 4.4/2.5 %. The disorder has strong genetic correlations with numerous mental disorders and neurological diseases, in particular with post-traumatic stress disorder, addiction to cannabis, cocaine, recurrent and bipolar affective disorders, behavioral disorders, which is the biological basis of its clinical polymorbidity. Symptoms of ADHD overlap with other clinical manifestations of neurodevelopmental disorders (symptoms of autistic spectrum disorders, speech disorders, movement disorders, dyslexia, cognitive impairment), forming a polymorphic spectrum of pervasive developmental variants. Psychostimulants have been the standard of ADHD treatment for over 50 years. In 2002, atomoxetine became the first nonstimulant medication approved by the Food and Drug Administration for the treatment of ADHD, first in children and later in adult patients. Stimulant and nonstimulant medications have been shown to be effective in different phenotypes of ADHD (comorbidity with other mental and neurological disorders). In case of comorbidity of ADHD with anxiety, tics, atomoxetine has an advantage over stimulants and, together with alpha-2-adrenergic receptor agonists, can be recommended as the first drug. The presence of comorbid anxiety disorder or recurrent depression does not impact the efficacy and side effects of atomoxetine. Thus, atomoxetine is an effective drug and not only improves the symptoms of ADHD, but also plays a certain role in the treatment of patients with comorbid depression and anxiety.