bluuebunny/crossref_metadata_2025_split huggingface dataset:
A memory system design framework
Authors: Firoozshahian Amin , Solomatnikov Alex , Shacham Ofer , Asgar Zain , Richardson Stephen , Kozyrakis Christos , Horowitz Mark 
Published: June 2009

As CPU cores become building blocks, we see a great expansion in the types of on-chip memory systems proposed for CMPs. Unfortunately, designing the cache and protocol controllers to support these memory systems is complex, and their concurrency and latency characteristics significantly affect the performance of any CMP. To address this problem, this paper presents a microarchitecture framework for cache and protocol controllers, which can aid in generating the RTL for new memory systems. The framework consists of three pipelined engines' request-tracking, state-manipulation, and data movement' which are programmed to implement a higher-level memory model. This approach simplifies the design and verification of CMP systems by decomposing the memory model into sequences of state and data manipulations. Moreover, implementing the framework itself produces a polymorphic memory system.
To validate the approach, we implemented a scalable, flexible CMP in silicon. The memory system was then programmed to support three disparate memory models' cache coherent shared memory, streams and transactional memory. Measured overheads of this approach seem promising. Our system generates controllers with performance overheads of less than 20% compared to an ideal controller with zero internal latency. Even the overhead of directly implementing a fully programmable controller was modest. While it did double the controller's area, the amortized effective area in the system grew by roughly 7%.
Boosting single-thread performance in multi-core systems through fine-grain multi-threading
Authors: Madriles Carlos , López Pedro , Codina Josep M. , Gibert Enric , Latorre Fernando , Martinez Alejandro , Martinez Raúl , Gonzalez Antonio 
Published: June 2009

Industry has shifted towards multi-core designs as we have hit the memory and power walls. However, single thread performance remains of paramount importance since some applications have limited thread-level parallelism (TLP), and even a small part with limited TLP impose important constraints to the global performance, as explained by Amdahl's law.
In this paper we propose a novel approach for leveraging multiple cores to improve single-thread performance in a multi-core design. The proposed technique features a set of novel hardware mechanisms that support the execution of threads generated at compile time. These threads result from a fine-grain speculative decomposition of the original application and they are executed under a modified multi-core system that includes: (1) mechanisms to support multiple versions; (2) mechanisms to detect violations among threads; (3) mechanisms to reconstruct the original sequential order; and (4) mechanisms to checkpoint the architectural state and recovery to handle misspeculations.
The proposed scheme outperforms previous hardware-only schemes to implement the idea of combining cores for executing single-thread applications in a multi-core design by more than 10% on average on Spec2006 for all configurations. Moreover, single-thread performance is improved by 41% on average when the proposed scheme is used on a Tiny Core, and up to 2.6x for some selected applications.
Guest column
Authors: Trevisan Luca 
Published: June 2009

Additive combinatorics is the branch of combinatorics where the objects of study are subsets of the integers or of other abelian groups, and one is interested in properties and patterns that can be expressed in terms of linear equations. More generally, arithmetic combinatorics deals with properties and patterns that can be expressed via additions and multiplications.
In the past ten years, additive and arithmetic combinatorics have been extremely successful areas of mathematics, featuring a convergence of techniques from graph theory, analysis and ergodic theory. They have helped prove long-standing open questions in additive number theory, and they offer much promise of future progress.
Techniques from additive and arithmetic combinatorics have found several applications in computer science too, to property testing, pseudorandomness, PCP constructions, lower bounds, and extractor constructions. Typically, whenever a technique from additive or arithmetic combinatorics becomes understood by computer scientists, it finds some application.
Considering that there is still a lot of additive and arithmetic combinatorics that computer scientists do not understand (and, the field being very active, even more will be developed in the near future), there seems to be much potential for future connections and applications.
Common Fixed Point and Approximation Results for Noncommuting Maps on Locally Convex Spaces
Authors: Akbar F. , Khan A. R. 
Published: June 2009

AbstractCommon fixed point results for some new classes of nonlinear noncommuting maps on a locally convex space are proved. As applications, related invariant approximation results are obtained. Our work includes improvements and extension of several recent developments of the existing literature on common fixed points. We also provide illustrative examples to demonstrate the generality of our results over the known ones.
Structural and Functional Alterations of FLT3 in Acute Myeloid Leukemia
Authors: Meshinchi Soheil , Appelbaum Frederick R. 
Published: June 2009

AbstractHematopoiesis is highly regulated through cytokine-induced stimulation of multiple signal transduction pathways in order to mediate appropriate differentiation and proliferation of specific progenitor populations. Ligand-induced stimulation of the FMS-like tyrosine kinase 3 (FLT3) leads to activation of multiple downstream effector pathways resulting in differentiation and proliferation of specific progenitor cell populations. Genomic alterations of the FLT3 gene, including FLT3 internal tandem duplication (FLT3/ITD) and FLT3 activation loop mutation (FLT3/ALM) lead to autonomous receptor activation, dysregulation of FLT3 signal transduction pathways, contribute to myeloid pathogenesis, and have been linked to response to therapy and clinical outcome. Exploring the mechanisms by which these FLT3 alterations lead to dysregulated proliferation should provide a better understanding of the molecular pathogenesis of acute myeloid leukemia (AML) and may provide insights into potential therapeutic interventions. FLT3 inhibitors are under evaluation for their efficacy in AML patients with FLT3 mutations.
Preclinical Results of Camptothecin-Polymer Conjugate (IT-101) in Multiple Human Lymphoma Xenograft Models
Authors: Numbenjapon Tontanai , Wang Jianyi , Colcher David , Schluep Thomas , Davis Mark E. , Duringer Julienne , Kretzner Leo , Yen Yun , Forman Stephen J. , Raubitschek Andrew 
Published: June 2009

Abstract
Purpose: Camptothecin (CPT) has potent broad-spectrum antitumor activity by inhibiting type I DNA topoisomerase (DNA topo I). It has not been used clinically because it is water-insoluble and highly toxic. As a result, irinotecan (CPT-11), a water-soluble analogue of CPT, has been developed and used as salvage chemotherapy in patients with relapsed/refractory lymphoma, but with only modest activity. Recently, we have developed a cyclodextrin-based polymer conjugate of 20-(S)-CPT (IT-101). In this study, we evaluated the preclinical antilymphoma efficacy of IT-101 as compared with CPT-11.
Experimental Design: We determined an in vitro cytotoxicity of IT-101, CPT-11, and their metabolites against multiple human lymphoma cell lines. In human lymphoma xenografts, the pharmacokinetics, inhibitions of tumor DNA topo I catalytic activity, and antilymphoma activities of these compounds were evaluated.
Results: IT-101 and CPT had very high in vitro cytotoxicity against all lymphoma cell lines tested. As compared with CPT-11 and SN-38, IT-101 and CPT had longer release kinetics and significantly inhibit higher tumor DNA topo I catalytic activities. Furthermore, IT-101 showed significantly prolonged the survival of animals bearing s.c. and disseminated human xenografts when compared with CPT-11 at its maximum tolerated dose in mice.
Conclusions: The promising present results provide the basis for a phase I clinical trial in patients with relapsed/refractory lymphoma.
Genomic Screening for Genes Silenced by DNA Methylation Revealed an Association between RASD1 Inactivation and Dexamethasone Resistance in Multiple Myeloma
Authors: Nojima Masanori , Maruyama Reo , Yasui Hiroshi , Suzuki Hiromu , Maruyama Yumiko , Tarasawa Isao , Sasaki Yasushi , Asaoku Hideki , Sakai Hajime , Hayashi Toshiaki , Mori Mitsuru , Imai Kohzoh , Tokino Takashi , Ishida Tadao , Toyota Minoru , Shinomura Yasuhisa 
Published: June 2009

Abstract
Purpose: Epigenetic changes such as DNA methylation play a key role in the development and progression of multiple myeloma. Our aim in the present study was to use genomic screening to identify genes targeted for epigenetic inactivation in multiple myeloma and assess their role in the development of resistance to dexamethasone.
Experimental Design: Gene expression was examined using microarray screening, reverse transcription-PCR, and real-time quantitative PCR. DNA methylation was examined using bisulfite PCR, bisulfite sequencing, and bisulfite pyrosequencing in 14 multiple myeloma cell lines, 87 multiple myeloma specimens, and 12 control bone marrow samples. WST-8 assays were used to assess cell viability after treatment with 5-aza-2′-deoxycytidine and/or dexamethasone.
Results: Microarray analysis was done to screen for genes up-regulated by 5-aza-2′-deoxycytidine. In RPMI8226 cells, 128 genes were up-regulated, whereas 83 genes were up-regulated in KMS12PE cells. Methylation of 22 genes with CpG islands in their 5′ regions, including RASD1, was confirmed. Methylation of RASD1 was associated with its inactivation, which correlated with resistance to dexamethasone. Treating multiple myeloma cells with 5-aza-2′-deoxycytidine restored sensitivity to dexamethasone. Methylation of RASD1 was also detected in a subset of primary multiple myeloma specimens, and the levels of methylation were increased after repeated antitumor treatments. Gene signature analysis revealed various genes to be synergistically induced by treatment with a combination of 5-aza-2′-deoxycytidine plus dexamethasone.
Conclusion: Our findings indicate that epigenetic inactivation of genes, including RASD1, plays a key role in the development of dexamethasone resistance in multiple myeloma. Moreover, they show the utility of demethylation therapy in cases of advanced multiple myeloma.
Activation of p38 Mitogen-Activated Protein Kinase Drives Dendritic Cells to Become Tolerogenic inRetTransgenic Mice Spontaneously Developing Melanoma
Authors: Zhao Fang , Falk Christine , Osen Wolfram , Kato Masashi , Schadendorf Dirk , Umansky Viktor 
Published: June 2009

AbstractPurpose: The purpose of the study was to investigate signaling molecules involved in the acquisition of tolerogenic properties by dendritic cells (DC) in ret transgenic mice with spontaneous melanoma progression and to target these molecules to overcome the barrier for effective melanoma immunotherapy.Experimental Design: DC functions and expression patterns of p38 mitogen-activated protein kinase (MAPK) in DCs were evaluated in a ret transgenic murine cutaneous melanoma model, which shows high similarity to human cutaneous melanoma with respect to clinical development. In contrast to transplantation melanoma models (like B16), this model allows the study of melanoma progression under conditions of natural interactions between tumor and host cells over time.Results: We showed a strong tumor infiltration with immature DCs and a reduction in the number of mature DCs in lymphoid organs during melanoma progression. DCs from melanoma-bearing mice secreted significantly more interleukin 10 and less interleukin 12p70, and showed a decreased capacity to activate T cells compared with DCs from tumor-free animals. Observed DC dysfunction was linked to considerable activation of p38 MAPK. Inhibition of its activity in spleen DCs from tumor-bearing mice led to normalization of their cytokine secretion pattern and T-cell stimulation capacity.Conclusions: Our data show a critical role of constitutively activated p38 MAPK in the acquirement of tolerogenic pattern by DCs during melanoma progression that contributes to the suppression of antitumor T-cell immune responses. We suggest that new strategies of melanoma immunotherapy can include inhibitors of p38 MAPK activity in DCs.
Urine Analysis and Protein Networking Identify Met as a Marker of Metastatic Prostate Cancer
Authors: Russo Andrea L. , Jedlicka Kimberly , Wernick Meredith , McNally Debbie , Kirk Melissa , Sproull Mary , Smith Sharon , Shankavaram Uma , Kaushal Aradhana , Figg William D. , Dahut William , Citrin Deborah , Bottaro Donald P. , Albert Paul S. , Tofilon Philip J. , Camphausen Kevin 
Published: June 2009

Abstract
Purpose: Metastatic prostate cancer is a major cause of death of men in the United States. Expression of met, a receptor tyrosine kinase, has been associated with progression of prostate cancer.
Experimental Design: To investigate met as a biomarker of disease progression, urinary met was evaluated via ELISA in men with localized (n = 75) and metastatic (n = 81) prostate cancer. Boxplot analysis was used to compare the distribution of met values between each group. We estimated a receiver operating characteristic curve and the associated area under the curve to summarize the diagnostic accuracy of met for distinguishing between localized and metastatic disease. Protein-protein interaction networking via yeast two-hybrid technology supplemented by Ingenuity Pathway Analysis and Human Interactome was used to elucidate proteins and pathways related to met that may contribute to progression of disease.
Results: Met distribution was significantly different between the metastatic group and the group with localized prostate cancer and people with no evidence of cancer (P &lt; 0.0001). The area under the curve for localized and metastatic disease was 0.90, with a 95% confidence interval of 0.84 to 0.95. Yeast two-hybrid technology, Ingenuity Pathway Analysis, and Human Interactome identified 89 proteins that interact with met, of which 40 have previously been associated with metastatic prostate cancer.
Conclusion: Urinary met may provide a noninvasive biomarker indicative of metastatic prostate cancer and may be a central regulator of multiple pathways involved in prostate cancer progression.
Mary's Womb as the 'Space Within Our Space for the Gestating Son of God'
Authors: Holness Lyn 
Published: June 2009

AbstractSpeaking of Mary's womb, Hans Urs von Balthasar draws attention to the place where the Word 'staked out' a space in a human being in order there itself to become man (human), as the child of a mother. In similar vein we are directed to the mystery that Catholic and Orthodox Christians have always overtly recognized: Mary's unique place among human beings as the one who 'contains the uncontainable God.' If this mystery lies at the heart of our faith, then at the heart of that heart is God's grace. In grace God selects a poor, Galilean girl to be the locus of what Christians believe to be the most extraordinary thing that has ever happened. There is much to learn about 'grace, space and race' through reflection on what occurred in Mary's womb, not least in the relationship between immanence and transcendence. This and other themes which have their origin here provide both the imagery and the theological undergirding for other themes – more concrete, specific, and contemporary – that we might explore in a theology of place in (South) Africa today.
The Displaced Calvin: 'Refugee Reality' as a Lens to Re-examine Calvin's Life, Theology and Legacy
Authors: Vosloo Robert 
Published: June 2009

AbstractDrawing on scholarship that highlights the fact that Calvin was a refugee who ministered to other refugees, this essay argues for a re-evaluation of 'the displaced Calvin' as source and motivation for Reformed witness today. The first part of the essay attends to some biographical details that amplify the centrality of the 'refugee reality' in Calvin's life. The second part of the paper traces the impact of this experiential reality on Calvin's theology, focusing mainly on how it may serve as a lens to aid our understanding of Calvin's reading of Scripture, as well as his doctrine of predestination. The brief conclusion suggests that, given increasing migration, displacement and xenophobia, the celebration of the legacy of the displaced Calvin requires a graceful theology of hospitality.
Re-placing Stewardship? Towards an Ethics of Responsible Care
Authors: Bruyns Clint Le 
Published: June 2009

AbstractThe churches' doctrine of stewardship has featured as both a blessing and bane for their engagement in public life to overcome economic ambiguities in contemporary society. This article discusses various critiques that are levelled at the stewardship impulse as well as some fundamental principles that should direct the churches toward an enlargement of their stewardship paradigms in ways that equip the churches for a more responsible stewardship ethic within their moral spaces. The promise of an ethics of responsible care is finally proposed as a means by which the theological resourcefulness and public impact of this biblically significant albeit controversial notion could be potentially advanced. As such it argues for repositioning the meaning and practice of stewardship in ways that better reflect its ethos of responsible care amidst economic challenges in public life.
Estimation of Atmospheric Motion Vectors from Kalpana-1 Imagers
Authors: Kishtawal C. M. , Deb S. K. , Pal P. K. , Joshi P. C. 
Published: June 2009

Abstract
The estimation of atmospheric motion vectors from infrared and water vapor channels on the geostationary operational Indian National Satellite System Kalpana-1 has been attempted here. An empirical height assignment technique based on a genetic algorithm is used to determine the height of cloud and water vapor tracers. The cloud-motion-vector (CMV) winds at high and midlevels and water vapor winds (WVW) derived from Kalpana-1 show a very close resemblance to the corresponding Meteosat-7 winds derived at the European Organisation for the Exploitation of Meteorological Satellites when both are compared separately with radiosonde data. The 3-month mean vector difference (MVD) of high- and midlevel CMV and WVW winds derived from Kalpana-1 is very close to that of Meteosat-7 winds, when both are compared with radiosonde. When comparing with radiosonde, the low-level CMVs from Kalpana-1 have a higher MVD value than that of Meteosat-7. This may be due to the difference in spatial resolutions of Kalpana-1 and Meteosat-7.
Possibility of the Visible-Channel Calibration Using Deep Convective Clouds Overshooting the TTL
Authors: Sohn B-J. , Ham Seung-Hee , Yang Ping 
Published: June 2009

Abstract
The authors examined the possible use of deep convective clouds (DCCs), defined as clouds that overshoot the tropical tropopause layer (TTL), for the calibration of satellite measurements at solar channels. DCCs are identified in terms of the Moderate Resolution Imaging Spectroradiometer (MODIS) 10.8-μm brightness temperature (TB11) on the basis of a criterion specified by TB11 ≤ 190 K. To determine the characteristics of these clouds, the MODIS-based cloud optical thickness (COT) and effective radius (re) for a number of identified DCCs are analyzed. It is found that COT values for most of the 4249 DCC pixels observed in January 2006 are close to 100. Based on the MODIS quality-assurance information, 90% and 70.2% of the 4249 pixels have COT larger than 100 and 150, respectively. On the other hand, the re values distributed between 15 and 25 μm show a sharp peak centered approximately at 20 μm. Radiances are simulated at the MODIS 0.646-μm channel by using a radiative transfer model under homogeneous overcast ice cloudy conditions for COT = 200 and re = 20 μm. These COT and re values are assumed to be typical for DCCs. A comparison between the simulated radiances and the corresponding Terra/Aqua MODIS measurements for 6 months in 2006 demonstrates that, on a daily basis, visible-channel measurements can be calibrated within an uncertainty range of ±5%. Because DCCs are abundant over the tropics and can be identified from infrared measurements, the present method can be applied to the calibration of a visible-channel sensor aboard a geostationary or low-orbiting satellite platform.
Engineered and Natural Marine Seep, Bubble-Driven Buoyancy Flows
Authors: Leifer Ira , Jeuthe Henrik , Gjøsund Svein Helge , Johansen Vegar 
Published: June 2009

Abstract
Bubble-plume upwelling flows were studied in the marine environment through dye releases into engineered plumes and a natural hydrocarbon seep plume. For engineered plumes, these experiments measured the water column–averaged upwelling flow Vup(zo) from release depth zo to the sea surface, for a wide range of flows Q, and zo. From Vup(zo), the local upwelling flow Vup(z), where z is depth, was calculated and found to vary with Q as Vup(z) ∼ Q0.23 for plumes strong enough to penetrate a shallow, thermally stratified layer, which was in good agreement with published relationships between Vup(z) and Q. These data were used to interpret data collected at a natural marine seep. For the seep, the upwelling flow decelerated toward the sea surface in contrast to the engineered plumes, which accelerated toward the sea surface. Data showed the seep bubble-plume upwelling flow lifted significantly colder and more saline water. The increased density difference between this upwelling fluid and the surrounding fluid most likely caused the deceleration. Midwater-column bubble measurements showed downcurrent detrainment of smaller bubbles from the bubble plume.
Synoptic- and Frontal-Scale Influences on Tropical Transition Events in the Atlantic Basin. Part I: A Six-Case Survey
Authors: Hulme Andrew L. , Martin Jonathan E. 
Published: June 2009

Abstract
The process by which a baroclinic, vertically sheared, extratropical cyclone is transformed into a warm-core, vertically stacked tropical cyclone is known as tropical transition. Six recent tropical transitions of strong extratropical precursors in the subtropical North Atlantic are compared to better understand the manner by which some of the canonical structures and dynamical processes of extratropical cyclones serve to precondition the cyclone for transition. All six transitions resulted from the interaction between a surface baroclinic zone and an upper-level trough. During the extratropical cyclogenesis of each storm, a period of intense near-surface frontogenesis along a bent-back warm front occurred to the northwest of each sea level pressure minimum. Within the resultant circulation, diabatic redistribution of potential vorticity (PV) promoted the growth of a low-level PV maximum near the western end of the warm front. Concurrently, the upper-level PV anomaly associated with each trough was deformed into the treble clef structure characteristic of extratropical occlusion. Thus, by the end of the transitioning process and just prior to its becoming fully tropical, each cyclone was directly beneath a weakened upper-level trough in a column with weak vertical shear and weak thermal contrasts. The presence of convection to the west and southwest of the surface cyclone at the time of frontogenesis and upper-level PV deformation suggests that diabatic heating contributes significantly to the process of tropical transition in a manner that is consistent with its role in extratropical occlusion. Thus, it is suggested that tropical transition is encouraged whenever extratropical occlusion occurs over a sufficiently warm ocean surface.