bluuebunny/crossref_metadata_2025_split huggingface dataset:
Continuity and Change in Substance Use Patterns During the Transition from Adolescence to Young Adulthood: Examining Changes in Social Roles
Authors: Merrin Gabriel J. , Bailey Jennifer A. , Kelly Adrian B. , Le Vi T. , Heerde Jessica A. , Doery Elizabeth , Batmaz Ebru A. , Toumbourou John W. 
Published: June 2024

AbstractThis study offers a model for using multidimensional growth mixture models to identify polysubstance use trajectories by examining transitions among conjoint substance use trajectories from adolescence to young adulthood and exploring potential moderators that may facilitate transitions towards healthier substance use trajectories in young adulthood. Longitudinal mixture modeling was used to examine six waves of data collected during adolescence (ages 13, 14, 15) and young adulthood (ages 25, 29, 31) in Seattle, Washington. Data were drawn from the International Youth Development Study, a longitudinal, cross-national study examining the life course patterns of substance use and development among youth. Participants (N = 961) completed questionnaires on six occasions that assessed demographics (sex, race, highest parent education), suspension and expulsion, individual substance use, partner substance use, and social role transitions (education, marriage, childbearing, employment). Four substance use classes were identified in adolescence and included low use (n = 572, 59.6%), alcohol dominant (n = 177, 18.4%), increasing use (n = 103, 10.7%), and poly-use (n = 109, 11.3%). Five substance use classes were identified in young adulthood and included low use (n = 134, 15.3%), alcohol only (n = 349, 39.8%), alcohol and tobacco (n = 97, 11.0%), alcohol and cannabis (n = 162, 18.5%), and poly-use (n = 135, 15.4%). The transition from adolescence to young adulthood showed the strongest continuity in the poly-use class and the weakest in the low use class, with a general trend toward adding substances rather than reducing them. College graduation moderated the transition in substance use patterns from adolescence to young adulthood for low use and alcohol dominant adolescent classes but not for the poly-use class. Delays in adult role assumptions were not consistently associated with substance use classes during this transition. However, where significant, delayed marriage and parenthood acted as protective factors against the progression of substance use leading into young adulthood. The findings underscore the need for early detection and tailored prevention efforts among adolescents. By identifying pivotal periods and specific substance use patterns, these findings inform the timing and focus of targeted interventions designed to reduce the escalation of substance use leading into young adulthood.
Mental Health and Wellbeing Literacy: a Cross-National Comparison
Authors: Burns Richard Andrew , Sargent Kerry , Crisp Dimity Ann 
Published: June 2024

AbstractThis cross-national study investigated the mental health and wellbeing literacy of adults through a series of discrimination tasks which assessed their ability to correctly discriminate statements of mental health and wellbeing. A cross-national sample of 1044 adults aged 18 years and older were recruited through Qualtrics Panels. Participants resided in Australia, the United Kingdom, Singapore, South Africa and Malaysia. Quota sampling was undertaken within countries for sex and age-groups (18 to 39 years, 40 to 59 years, and 60 + years). Participants were assigned into one of two conditions in which mental health and wellbeing statements were either negatively or positively framed. In the first task, participants reported moderate levels of mental health and wellbeing literacy and there was consistency between nations in participants’ discrimination of statements. In the second discrimination task, participants now classified most statements indicators as reflecting “both mental health and wellbeing”. The findings suggest that while community members can mostly discriminate between statements of wellbeing and mental health, they will generally define these statements as reflecting dimensions of both mental health and wellbeing. For community members, it may be less important to discriminate between mental health and wellbeing but instead simply focus on overall psychological health which reflects both absence of pathology and presence of wellbeing.
Distribution of plant species Iris sibirica and its vegetation affinity in Slovakia
Authors: Hrivnák Richard , Slezák Michal , Dudáš Matej , Galvánek Dobromil , Labovská Tereza , Miháliková Tatiana 
Published: June 2024

AbstractIris sibirica is a threatened plant species of the Central European flora, but its distribution and vegetation ecology in Slovakia have not been studied so far. Therefore, we aimed to compile a complex chorology of this species and to analyse phytosociological plots with the species occurrence. Our results suggest that Iris sibirica occurs almost in the whole Slovakia, with two distributional centres situated in the south-western region (Pannonian bioregion) and in the southern regions of central Slovakia (Carpathian bioregion), but a higher proportion of recent records was identified in the Carpathians. Vegetation classification using the TWINSPAN algorithm divided 80 vegetation plots into 5 clusters. They were interpreted syntaxonomically as follows: i) Calthion palustris alliance, ii) Deschampsion cespitosae alliance, iii) Molinion caeruleae alliance, iv) vegetation of the successional stages and transitional status between wet meadows (Calthion palustris and Molinion caeruleae) and fens (Scheuchzerio palustris-Caricetea fuscae), and v) vegetation with a transitional status between hygrophilous, fen vegetation of the alliances Molinion caeruleae, Caricion davallianae, Caricion fuscae and mesic habitats. Variation in the species composition of vegetation plots, analysed using detrended correspondence analysis (DCA) and interpreted using Ellenberg indicator values for vascular plants, showed a shift along the first DCA axis from taxa typical for nutrient-rich and shaded but thermophilic sites to taxa of open and relatively cold habitats on nutrient-poor soils. The second DCA axis corresponded to the moisture gradient, which controlled the pattern of plant species richness.
Lifestyle Changes and Industrialization in the Development of Allergic Diseases
Authors: Ozdemir Cevdet , Kucuksezer Umut Can , Ogulur Ismail , Pat Yagiz , Yazici Duygu , Ardicli Sena , Akdis Mubeccel , Nadeau Kari , Akdis Cezmi A. 
Published: June 2024

Abstract
Purpose of Review
Modernization and Westernization in industrialized and developing nations is associated with a substantial increase in chronic noncommunicable diseases. This transformation has far-reaching effects on lifestyles, impacting areas such as economics, politics, social life, and culture, all of which, in turn, have diverse influences on public health. Loss of contact with nature, alternations in the microbiota, processed food consumption, exposure to environmental pollutants including chemicals, increased stress and decreased physical activity jointly result in increases in the frequency of inflammatory disorders including allergies and many autoimmune and neuropsychiatric diseases. This review aims to investigate the relationship between Western lifestyle and inflammatory disorders.

Recent Findings
Several hypotheses have been put forth trying to explain the observed increases in these diseases, such as ‘Hygiene Hypothesis’, ‘Old Friends’, and ‘Biodiversity and Dysbiosis’. The recently introduced ‘Epithelial Barrier Theory’ incorporates these former hypotheses and suggests that toxic substances in cleaning agents, laundry and dishwasher detergents, shampoos, toothpastes, as well as microplastic, packaged food and air pollution damage the epithelium of our skin, lungs and gastrointestinal system. Epithelial barrier disruption leads to decreased biodiversity of the microbiome and the development of opportunistic pathogen colonization, which upon interaction with the immune system, initiates local and systemic inflammation.

Summary
Gaining a deeper comprehension of the interplay between the environment, microbiome and the immune system provides the data to assist with legally regulating the usage of toxic substances, to enable nontoxic alternatives and to mitigate these environmental challenges essential for fostering a harmonious and healthy global environment.
Transcatheter Therapy for the Tricuspid Valve: A Focused Review of Edge-to-Edge Repair and Orthotopic Valve Replacement
Authors: Madhavan Mahesh V. , Agarwal Vratika , Hahn Rebecca T. 
Published: June 2024

Abstract
Purpose of Review
Patients with severe tricuspid regurgitation (TR) are at risk for significant morbidity and mortality. Transcatheter tricuspid valve interventions (TTVI) may offer patients less invasive treatment alternatives to surgery. This review evaluates the most common class of device currently used worldwide to treat TR, tricuspid transcatheter edge-to-edge repair (T-TEER) and orthotopic transcatheter tricuspid valve replacement (TTVR), both of which are now approved in the USA and Europe.

Recent Findings
The first pivotal randomized clinical trial, TRILUMINATE, demonstrated that T-TEER can safely reduce TR and is associated with improved health status outcomes. However, results of this trial have raised questions about whether this device can provide sufficient TR reduction to impact clinical outcomes. Orthotopic TTVR has recently gained attention with initial data suggesting near-complete TR elimination.

Summary
The current review examines the technical features and anatomic limitations of the most commonly used devices for T-TEER and orthotopic TTVR, discusses the current clinical data for these devices, and offers a theoretical construct for device selection.
Cross-Cultural Patient Counseling and Communication in the Integrative Medicine Setting: Respecting the Patient's Health Belief Model of Care
Authors: Ben-Arye Eran , Lopez Gabriel , Rassouli Maryam , Ortiz Miriam , Cramer Holger , Samuels Noah 
Published: June 2024

AbstractPurpose of ReviewCommunicating effectively with patients having a traditional, alternative or complementary medicine-related health-belief model is challenging in today’s cross-cultural society. This narrative review explores the integrative medicine setting of care, focusing on insights from the integrative oncology daily practice, while addressing the relevance to the mental health setting. The way in which healthcare providers can enhance cultural-sensitive communication with patients and informal caregivers; recognize and respect health-beliefs to bridge cultural gaps; and generate an open, non-judgmental and mindful dialogue are discussed.Recent FindingsIdentifying cross-cultural barriers to healthcare provider-patient communication is important in order to address the potential for conflict between conventional and “alternative” health beliefs; difficulties in creating a shared-decision making process; disagreement on therapeutic goals and treatment plan; and finally, the potential for non-compliance or non-adherence to the conventional oncology treatment.SummaryAcquiring intercultural competencies is needed at all stages of medical education, and should be implemented in medical and nursing curricula, as well as during specialization and sub-specialization. As with patient-centered paradigms of care, integrative medicine entails a dual patient-centered and sensitive-cultural approach, based on a comprehensive bio-psycho-social-spiritual model of care.
Oral Papillary Squamous Cell Carcinoma and Oral Squamous Cell Carcinoma: A Histopathological and Immunohistochemical Comparative Study
Authors: Mahmoud Esraa Ashraf , Abdellatif Mohsen Kazem , Mahmoud Sarah Ahmed Mohammed 
Published: June 2024

Abstract
Purpose
The aim of the study is to investigate the immunohistochemical expression of both Alpha smooth muscle actin and Transforming Growth Factor beta and compare their expression in oral papillary squamous cell carcinoma with their expression in different histological grades of oral squamous cell carcinoma. A correlation between these immuno-histochemical expressions and histological findings will then be performed. The research question is “Do the percentages of α-SMA and TGF-β immune-expression in OPSCC differ from that in the conventional OSCC?”.

Methods
This will be achieved by collecting archival blocks of oral papillary squamous cell carcinoma and different grades of oral squamous cell carcinoma, staining the specimens with Transforming Growth Factor beta and alpha smooth muscle actin, then measuring the mean staining index of expression in each group and the area percent of both markers.

Results
Results revealed that transforming growth factor beta expression in the epithelium was high in all cases of well-differentiated squamous cell carcinoma, most oral papillary squamous cell carcinoma, and poorly differentiated oral squamous cell carcinoma. On the other hand, different grades of oral squamous cell carcinoma showed a high staining index of alpha smooth muscle actin expression in the stroma. While cases of oral papillary squamous cell carcinoma were either moderate or low-staining.

Conclusions
Oral papillary squamous cell carcinoma has a favourable prognosis compared to different histological grades, and the prognosis does not depend only on histological grade but also on other prognostic factors.
Poincaré Inequality and Topological Rigidity of Translators and Self-Expanders for the Mean Curvature Flow
Authors: Impera Debora , Rimoldi Michele 
Published: June 2024

AbstractWe prove an abstract structure theorem for weighted manifolds supporting a weighted f-Poincaré inequality and whose ends satisfy a suitable non-integrability condition. We then study how our arguments can be used to obtain full topological control on two important classes of hypersurfaces of the Euclidean space, namely translators and self-expanders for the mean curvature flow, under either stability or curvature asumptions. As an important intermediate step in order to get our results we get the validity of a Poincaré inequality with respect to the natural weighted measure on any translator and we prove that any end of a translator must have infinite weighted volume. Similar tools can be obtained for properly immersed self-expanders permitting to get topological rigidity under curvature assumptions.
Vaccarin Ameliorates Doxorubicin-Induced Cardiotoxicity via Inhibition of p38 MAPK Mediated Mitochondrial Dysfunction
Authors: Shi Xin , Cao Yang , Wang Hongyu , Zhao Qi , Yan Cong , Li Shengzhu , Jing Ling 
Published: June 2024

AbstractDoxorubicin is a frequently used chemotherapeutic agent for treating various malignancies. However, it leads to severe cardiotoxic side effects, such as heart failure, and elevates the risk of sudden cardiac death among cancer patients. While oxidative stress has been identified as the primary cause of doxorubicin-induced cardiotoxicity, therapeutic antioxidant approaches have yielded unsatisfactory outcomes. The aim of this study is to explore the therapeutic potential of vaccarin, an active flavonoid glycoside extracted from traditional Chinese herbal agent Semen Vaccariae, in doxorubicin-induced cardiotoxicity. We observed that vaccarin significantly ameliorates doxorubicin-induced heart dysfunction in mouse model and suppresses oxidative stress mediated cell apoptosis via specifically inhibiting the activation of p38 MAPK pathway. In vitro, we observed that vaccarin alleviates doxorubicin-induced mitochondrial membrane depolarization and ROS generation in H9c2 cell, but the p38 MAPK agonist anisomycin reverses these effects. Our findings provide a promising natural antioxidant to protect against DOX-induced cardiotoxicity.
Graphic Abstract
PG I and PG II show unique value in diagnosing postoperative biochemical recurrence in patients with gastric cancer after total gastrectomy
Authors: Zhang Jiuru , Liu Jiameng , Dong Liyang , Wang Xi , Mao Xueqian , Mao Yufei , Mao Chaoming 
Published: June 2024

Abstract
Objective
To investigate the potential of group I pepsinogen (PG I) and group II pepsinogen (PG II) as diagnostic markers for recurrence in gastric cancer (GC) patients post-total gastrectomy.

Methods
Ninety-six patients who underwent total gastrectomy for GC between June 2022 and June 2023 were included in this study. Clinical data, serum samples, and ascites samples were collected. Patients were categorized based on recurrence status at the time of sample collection and the primary tumor site. PG I and PG II levels were determined using a chemiluminescent immunoassay, and their clinical utility following total gastrectomy for GC was evaluated via receiver operating characteristic (ROC) curve analysis.

Results
This study included 96 GC patients who underwent total gastrectomy, 55 of whom experienced postoperative recurrence (57.29%). The levels of serum PG I (27.86 (27.04, 30.97) vs. 26.05 (24.16, 27.09) ng/mL; P < 0.0001) and PG II (1.95 (1.23, 3.05) vs. 0.63 (0.47, 0.90) ng/mL; P < 0.0001) were significantly greater in the recurrent group compared to the non-recurrent group. The secretion of PG I and/or PG II by metastatic cancer cells correlated with the primary lesion site. When the cut-off value for serum PG I was 26.93 ng/mL, the area under the curve (AUC) for PG I was 0.77. When the cut-off value for serum PG II was 0.96 ng/mL, the AUC reached 0.90. The combined AUC was 0.97.

Conclusion
These findings suggest that serum PG I and PG II are valuable biomarkers for identifying GC patients with biochemical recurrence post-total gastrectomy.
Prediction of prognosis in glioblastoma with radiomics features extracted by synthetic MRI images using cycle-consistent GAN
Authors: Yoshimura Hisanori , Kawahara Daisuke , Saito Akito , Ozawa Shuichi , Nagata Yasushi 
Published: June 2024

AbstractTo propose a style transfer model for multi-contrast magnetic resonance imaging (MRI) images with a cycle-consistent generative adversarial network (CycleGAN) and evaluate the image quality and prognosis prediction performance for glioblastoma (GBM) patients from the extracted radiomics features. Style transfer models of T1 weighted MRI image (T1w) to T2 weighted MRI image (T2w) and T2w to T1w with CycleGAN were constructed using the BraTS dataset. The style transfer model was validated with the Cancer Genome Atlas Glioblastoma Multiforme (TCGA-GBM) dataset. Moreover, imaging features were extracted from real and synthesized images. These features were transformed to rad-scores by the least absolute shrinkage and selection operator (LASSO)-Cox regression. The prognosis performance was estimated by the Kaplan–Meier method. For the accuracy of the image quality of the real and synthesized MRI images, the MI, RMSE, PSNR, and SSIM were 0.991 ± 2.10 $$\times {10}^{-4}$$

×

10

-
4

, 2.79 ± 0.16, 40.16 ± 0.38, and 0.995 ± 2.11 $$\times {10}^{-4}$$

×

10

-
4

, for T2w, and .992 ± 2.63 $$\times {10}^{-4}$$

×

10

-
4

, 2.49 ± 6.89 $$\times {10}^{-2}$$

×

10

-
2

, 40.51 ± 0.22, and 0.993 ± 3.40 $$\times {10}^{-4}$$

×

10

-
4

for T1w, respectively. The survival time had a significant difference between good and poor prognosis groups for both real and synthesized T2w (p < 0.05). However, the survival time had no significant difference between good and poor prognosis groups for both real and synthesized T1w. On the other hand, there was no significant difference between the real and synthesized T2w in both good and poor prognoses. The results of T1w were similar in the point that there was no significant difference between the real and synthesized T1w. It was found that the synthesized image could be used for prognosis prediction. The proposed prognostic model using CycleGAN could reduce the cost and time of image scanning, leading to a promotion to build the patient’s outcome prediction with multi-contrast images.
Heavy metals and microbial assessment of air conditioning condensate water in Jeddah city-Saudi Arabia: concept of sustainable water resources
Authors: AlGhamdi Shareefa A. , Alromi Deemah , Jambi Ebtihaj , Alzughaibi Torki , Al-Ansari Ahmed 
Published: June 2024

AbstractThe demand for water is rising worldwide, especially in Saudi Arabia, where the existing water sources are barely sufficient to meet the present requirements. Condensates from air-conditioning units can be invested as an economical and supportive source of available water resources, which can be considered within global water supply accounts. The aim of the present study is to examine the possibility of recovering condensate water from air conditioner (AC) systems by determining the quantity and quality of AC water generated by either split or window AC systems. The results showed that split air conditioner systems were more effective than window-type air conditioners in generating condensate water in terms of quantity and quality. There was a significant correlation between the humidity and water content. The results indicate that the annual amount of water generated was 8,725 L for window AC and 20,614 L for split AC. The recorded levels of all elements in the water samples obtained from both the window and split air conditioning units, including pH, TDS, EC, PO4-3, Cl-, SO4-2, COD, and heavy metals, were found to be within the acceptable thresholds set for both drinking water and irrigation purposes. Bacteria were only present in three water samples from the window AC, and all were non-pathogenic. Utilizing air conditioner condensate as a strategic measure can address the issue of water scarcity in Saudi Arabia’s agricultural and industrial sectors. The findings of this study are extremely relevant and opportune, especially given the growing concerns about water scarcity and the need to conserve resources. By demonstrating that the HVAC water condensate is clean and safe for consumption, this study adds to our understanding of how we can make better use of available resources.
The Root Extraction Problem in Braid Group-Based Cryptography
Authors: Cumplido María , Kahrobaei Delaram , Noce Marialaura 
Published: June 2024

AbstractThe root extraction problem in braid groups is the following: given a braid $$\beta \in \mathcal {B}_n$$

β
∈

B
n

and a number $$k\in \mathbb {N}$$

k
∈
N

, find $$\alpha \in \mathcal {B}_n$$

α
∈

B
n

such that $$\alpha ^k=\beta $$

α
k

=
β

. In the last decades, several cryptosystems based on the root extraction problem, including authentication schemes and digital signatures, have been proposed. In this survey paper, we describe these cryptosystems built around braid groups. Then we explain that, in general, these authentication schemes and digital signatures are not secure, and we present for each of them a possible attack.