bluuebunny/crossref_metadata_2025_split huggingface dataset:
Preoperative severe pain, decreased function, and high anxiety levels increase preoperative anxiety in patients who underwent primary total knee arthroplasty
Authors: Park Ki-Bong , Jeon Young Dae , Kim Sang-Gon , Park Jae-Hwan 
Published: May 2024

Abstract

Patients experience clinically significant anxiety from the time they are recommended to undergo total knee arthroplasty (TKA). This study aimed to evaluate the efficacy of a preoperative intervention regarding anxiety levels in patients undergoing TKA for knee osteoarthritis (OA) and to evaluate whether patient characteristics affect the effectiveness of the intervention according to anxiety level.
This retrospective observational study recruited 89 patients who underwent TKA under general anesthesia for knee OA. The preoperative intervention comprised rehabilitation education and an interview with an orthopedic surgeon regarding surgical preparation status. The State-Trait Anxiety Inventory (STAI) was administered before and after the preoperative intervention.
The mean STAI score significantly improved after the intervention. The proportion of patients with clinically meaningful state anxiety (CMSA) also significantly decreased after the intervention. There were no significant differences in demographic and social factors between the two groups. However, the patients whose CMSA status did not improve experienced severe pain, poor functional scores, and high anxiety scores.
For patients undergoing TKA, the implementation of a patient-specific intervention, which consists of preoperative rehabilitation education and a surgeon interview, helps reduce preoperative anxiety. However, these interventions may not be effective in patients who present with severe pain, poor functional status, or high anxiety levels before surgery. Thus, higher levels of intervention for anxiety may be necessary.
Characteristics and Outcomes in Bladder Leiomyoma Management: A Systematic Review of Case Reports and Case Series from the Past 20 Years
Authors: Prihadi Johannes Cansius , Hengky Antoninus , Lionardi Stevan Kristian , Haruman Sean Peter 
Published: May 2024

Abstract

Introduction
Less than 0.5% of cases are bladder leiomyomas, which are uncommon, non-cancerous growths that originate from the smooth muscle cells of the bladder. The purpose of this review is to compile existing data and present a summary of bladder leiomyomas' characteristics, management, and related outcomes.
Method
Case studies or series describing individuals with bladder leiomyoma who underwent surgery and the results they reported thereafter were included. Four databases were used in our literature search, which was carried out until January 2024: PubMed, Proquest, EBSCOHost, and Google Scholar. We utilized MeSH terms such "leiomyoma," "urinary bladder," and looked for synonyms of "bladder leiomyoma" in free text.
Results
The majority of reported bladder leiomyoma cases were in female accounting for 77.7% of all cases. While symptomatic patients primarily presented with lower urinary tract symptoms (LUTS) (60.7%), hematuria (23.0%), acute urine retention (11.5%), and about 16.4% of cases were incidentally detected. Storage-related symptoms were the most common LUTS (32.8%). Different diagnostic techniques were used, frequently combining CT, MRI, USG, and/or cystoscopy. Bladder leiomyomas were commonly found on left lateral wall (26.4%) and the bladder neck (17.4%). In more than half of the cases (51.2%) the treatment techniques used were transurethral resection (TURBt/TUR). Fifteen out of 121 cases had recurrence or remain symptomatic.
Conclusion
Further investigation is necessary to fully understand the best course of treatment and long-term results for bladder leiomyomas. In particular, prospective trials with bigger participant pools and meticulously controlled factors should be the main emphasis of this research.
Triple Positive for Anti-MDA5, Anti-EJ and Anti-Ro52 Antibodies Dermatomyositis Associated Interstitial Lung Disease：a case report
Authors: Guo Jia , Du Lingjie , Xu Bo , Tan Chunting , Zhao Ranran 
Published: May 2024

Abstract

Background
Clinically amyopathic dermatomyositis (CADM) is a disease with the typical skin manifestations of dermatomyositis (DM) and few or no obvious muscle weakness. The anti-melanoma differentiation associated protein 5（MDA5）antibody positive CADM patients are at a high risk of developing rapidly progressive interstitial lung disease (RP-ILD)，and exhibit immensely poor prognosis and high mortality. The disease course and severity of MDA5+CAMD are highly different, wherein some patients presented marked treatment response and didn’t occur exacerbation. Analysis to these special groups bring us better understanding of MDA5+CADM.
Case presentation
We presented a patient with anti-MD5 anti-Ro52 anti-EJ-triple positive DM patient. She was initially characteristic with darken skin for 2 years before gradually occurred dry cough, fever and dyspnea. She had a low oxygen saturation and diffusing capacity of the lungs for carbon monoxide. With combination therapy of GCs and two immunosuppressants, the woman obtained a rapid remission and persisted for a long time.
Conclusions
Patients with anti-MD5 anti-Ro52 anti-EJ-triple positive DM-ILD may present a less aggressive disease course and an individual appropriate therapy may be promising for long-term maintenance.
Machine Learning Identifies Variation in Timing of Palliative Care Consultations Among Traumatic Brain Injury Patients
Authors: Aude Carlos A. , Vattipally Vikas N. , Das Oishika , Ran Kathleen R. , Giwa Ganiat A. , Rincon-Torroella Jordina , Xu Risheng , Byrne James P. , Muehlschlegel Susanne , Suarez Jose I. , Mukherjee Debraj , Huang Judy , Azad Tej D. , Bettegowda Chetan 
Published: May 2024

Abstract

Background and Objective

Timely palliative care involvement offers demonstrable benefits for traumatic brain injury (TBI) patients; however, palliative care consultations (PCCs) are used inconsistently during TBI management. This study aimed to employ advanced machine learning techniques to elucidate the primary drivers of PCC timing variability for TBI patients.

Methods

Data on admission, hospital course, and outcomes were collected for a cohort of 232 TBI patients who received both PCCs and neurosurgical consultations during the same hospitalization. Principal Component Analysis (PCA) and K-means clustering were used to identify patient phenotypes, which were then compared using Kaplan-Meier analysis. An extreme gradient boosting model (XGBoost) was employed to determine drivers of PCC timing, with model interpretation performed using SHapley Additive exPlanations (SHAP).

Results

Cluster A (n = 86) consisted mainly of older (median [IQR] = 87 [78, 94] years), White females with mild TBIs and demonstrated the shortest time-to-PCC (2.5 [1.0, 7.0] days). Cluster B (n = 108) also sustained mild TBIs but comprised moderately younger (81 [75, 86] years) married White males with later PCC (5.0 [3.0, 10.8] days). Cluster C (n = 38) represented much younger (46.5 [29.5, 59.8] years), more severely injured, non-White patients with the latest PCC initiation (9.0 [4.2, 17.0] days). The clusters did not differ by discharge disposition (p = 0.4) or frequency inpatient mortality (p > 0.9); however, Kaplan-Meier analysis revealed a significant difference in the time from admission to PCC (p < 0.001), despite no differences in time from admission to mortality (p = 0.18). SHAP analysis of the XGBoost model identified age, sex, and race as the most influential drivers of PCC timing.

Conclusions

This study highlights crucial disparities in PCC timing for TBI patients and underscores the need for targeted strategies to ensure timely and equitable palliative care integration for this vulnerable population.
Differential effects of self-administered and receptive sound intervention on cardiovascular parameters in cancer patients: A randomized cross-over trial
Authors: Hohneck Anna , Kolar Valentin , Troia Melissa , Weingärtner Simone , Merx Kirsten , Sarodnick Felicitas , Mavratzas Athanasios , Burkholder Iris , Schumacher Gerhard , Hofmann Wolf-Karsten , Hofheinz Ralf-Dieter 
Published: May 2024

Abstract

Aim This study aimed to assess differential effects on cardiovascular parameters and subjective perceptions of a self-administered (active) or receptive sound intervention in cancer patients.
Methods Using a randomized cross-over design, patients with cancer were recruited to undergo both, a 15-minute self-administered or receptive sound intervention using (sound of) a body monochord, respectively. During self-administered intervention patients were asked to play a body monochord, while receiving prerecorded instructions via headphones. During receptive sound intervention both a prerecorded audio file with explanations, as well as monochord sounds were applied via headphones. Before (pre) and after (post) intervention, cardiovascular parameters (measured by VascAssist2.0) and subjective feelings and emotions (measured by visual analogue scales) were assessed.
Results 50 patients (18 male, 32 female) with a median age of 60 years (range 29 – 79) were included. Both interventions led to a significant reduction in heart rate (p < 0.001), with a more pronounced effect in the receptive group (median reduction -2.0 bpm (active) vs median reduction -4.0 bpm (receptive), p = 0.01). Vascular resistance index was reduced by both interventions, though failing to reach statistical significance in the active group (receptive: median reduction ‑2.2, p < 0.001; active: median reduction -0.5, p = 0.053; active vs receptive: p = 0.77). This was also reflected in a greater, but not statistically different reduction in pulse wave velocity (PWV) for receptive intervention (active: median reduction -0.4 m/s, p = 0.002; receptive: median reduction -0.5 m/s, p < 0.001; active vs receptive: p = 0.21). Both interventions led to an increase in emotional well-being, while anger, anxiety, sadness, emotional stress and fatigue were significantly reduced. Pain, on the other hand, was only reduced by receptive intervention (median reduction -1.0, p = 0.04), but not significantly different compared to active intervention (p = 0.99).
Conclusion Both self-administered and receptive sound interventions are able to improve cardiovascular parameters and subjective feelings and emotions in cancer patients. Receptive intervention by trend appeared to have more pronounced effects on vascular function (reduced resistance and PWV) and on pain management.
Growth and Physiological Characteristics of Forage Bermudagrass in Response to salt stress
Authors: Cui Xinyu , Chen Jianmin , Li Shuang , Shao An , Fu Jinmin 
Published: May 2024

Abstract

Background. Bermudagrass (Cynodon dactylon) has a long history as an excellent forage grass, and salt stress will inhibit its growth and development. In order to minimize the damage, it is necessary to continuously develop innovative technologies and management strategies.
Results. This study evaluated the salt tolerance of new Bermudagrass strains 'FB2019R101' and 'FB2019R105' compared to commercial varieties 'Wrangler' and 'A12359' under simulated soil salinity conditions through seawater irrigation. Through correlation analysis of growth, physiological, and nutritional indicators, and principal component analysis, core indicators and weights for salt tolerance evaluation were identified. The salt-tolerant varieties were 'FB2019R101' and 'FB2019R105'. Under salinity stress, the plants of Bermudagrass varieties with salt tolerance suffered less damage as a whole, which could better regulate the osmotic balance inside and outside cells, accumulate more nutrients and have stronger ability to resist salt damage.
Conclusions. 'FB2019R101' and 'FB2019R105' exhibited higher salt tolerance, with minimal impact on their biomass, physiological, and nutritional indicators under salt stress. The comprehensive evaluation revealed a salt tolerance ranking of 'FB2019R105' > 'FB2019R101' > 'Wrangler' > 'A12359'. This study provides significant reference for the bioremediation of coastal saline soils and promotes research on the application of Bermudagrass under salt stress conditions.
Building on the clinical applicability of ctDNA analysis in non-metastatic pancreatic ductal adenocarcinoma
Authors: Labiano Ibone , Huerta Ana E , Alsina Maria , Arasanz Hugo , Castro Natalia , Mendaza Saioa , Lecumberri Arturo , Gonzalez-Borja Iranzu , Guerrero-Setas David , Patiño-Garcia Ana , Alkorta-Aranburu Gorka , Hernandez-Garcia Irene , Arrazubi Virginia , Mata Elena , Gomez David , Viudez Antonio , Vera Ruth 
Published: May 2024

Abstract

Background. Pancreatic ductal adenocarcinoma (PDAC) represents one of the worst prognostic cancers worldwide, with a high recurrence rate after adjuvant or neoadjuvant therapy (NAT). Circulating tumor DNA (ctDNA) analysis raised as a promising non-invasive tool to characterize tumor genomics and to assess treatment response.Methods. In this study, surgical tumor tissue and sequential blood samples were analyzed by next-generation sequencing and were correlated with clinical and pathological characteristics. Thirty resectable/borderline PDAC patients treated at the Hospital Universitario de Navarra (HUN) were included.Results. ctDNA sequencing identified pathogenic variants in KRAS and TP53, and in other cancer-associated genes. Pathogenic variants at diagnosis were detected in patients with a poorer outcome, and were correlated with response to NAT in borderline PDAC patients. Higher variant allele frequency (VAF) at diagnosis was associated with worse prognosis, and VAF sum was greater in samples at progression.Conclusion. Our results build on the potential value of ctDNA for non-metastatic PDAC patients, by complementing tissue genetic information and as a non-invasive tool for treatment decision. Confirmatory studies are needed to corroborate these findings.
Analysis and Implementation of Nonlocal Governing Operators with Local Boundary Conditions on a General Interval
Authors: Aksoylu Burak , Celiker Fatih , Diehl Patrick 
Published: May 2024

Abstract

We study nonlocal operators that enforce local boundary conditions on a general interval $(a,b)$. We prove the bijectivity of the operators in suitable spaces which leads to the well-posedness of the problems in the infinite dimensional setting. The operators are discretized using collocation methods. Their optimal convergence properties are established rigorously utilizing the theory of Fredholm operators of the second kind and the Hilbert-Schmidt property. The theoretical results are verified with numerical experiments.
Genome-wide exploration of MTP gene family in mustard (Brassica juncea L.): evolution and expression patterns during heavy metal stress
Authors: You Liang , Sheng Jialin , Jiang Guoxiang , Chen Hao , Yuan Yuhui , Gong Sha , Yan Mingli , Hu Junhe , Xiang Guohong , Duan Renyan , Chen Yong , Liu Xianjun 
Published: May 2024

Abstract

Members of the Metal Tolerance Protein (MTP) family are critical in mediating the transport and tolerance of divalent metal cations. Despite their significance, little is known about the MTP genes in mustard (Brassica juncea), particularly in relation to how they react to HM stress. In our study, we identified MTP gene sets in Brassica rapa (17 genes), Brassica nigra (18 genes), and B. juncea (33 genes) using the HMMER tool (Cation_efflux; PF01545) and BLAST analysis. Then, for the 33 BjMTPs, we carried out a detailed bioinformatics analysis covering the physicochemical properties, phylogenetic relationships, conserved motifs, protein structures, collinearity, spatiotemporal RNA-seq expression, GO enrichment, and expression profiling under six HM stresses (Mn2+, Fe2+, Zn2+, Cd2+, Sb3+, and Pb2+). According to the findings of physicochemical characteristics and phylogenetic tree, the allopolyploid B. juncea’s MTP genes were inherited from its progenitors, B. rapa and B. nigra, with minimal gene loss during polyploidization. The BjMTP gene family exhibited conserved motifs, promoter elements, and expression patterns that aligned with seven evolutionary branches (G1, G4-G9, and G12). Further, by co-expression analysis, the core and gene-specific expression modules of BjMTPs under six HM stresses were found. The HM treatments exhibited consistently upregulated of BjA04.MTP4, BjA09.MTP10, and BjB01.MTP5 genes, indicating their critical roles in enhancing HM tolerance in B. juncea. These discoveries may contribute to a genetic improvement in B. juncea's HM tolerance, which would facilitate the remediation of HM-contaminated areas.
Real-world Pharmacovigilance Study of Famciclovir in the FDA Adverse Event Reporting System (FAERS) Database
Authors: Fang Runan , Zhou Yang , Han Lu , Chen Wenjing , Guan Ning , Li Jianhong 
Published: May 2024

Abstract

Background
Famciclovir, mainly used to treat herpes zoster, is a precursor drug of penciclovir that rapidly transforms into penciclovir when taken orally and sustains an extended half-life intracellularly. The information on its adverse drug reactions (ADRs) mainly comes from clinical trials, lacking large-scale real-world studies. This study evaluates the adverse events (AEs) of famciclovir by mining data from the FDA Adverse Event Reporting System (FAERS) database, providing references for clinical safety.
Methods
Utilized disproportionality analysis (including reported odds ratio and proportional reporting ratio) and Bayesian methods (including Bayesian Confidence Propagation Neural Network and Gamma-Poisson Shrinkage) to quantify AE signals associated with famciclovir.
Results
A total of 17,652,186 case reports were obtained from the FAERS database, with 432 reports of famciclovir-related AEs identified. The most common AEs were nausea, headache, altered mental status, vomiting, and dizziness, corresponding to the AEs reported in guidelines and clinical trials. However, there were AEs not mentioned in the medication guide, such as toxic encephalopathy, encephalopathy, ataxia, dysarthria, dementia, cerebral infarction, tremor, purpura, skin ulcers, acute pancreatitis, rhabdomyolysis, muscle twitching, increased blood urea, lowered blood pressure, hepatitis, disease recurrence, drug interactions, and pancytopenia.
Conclusion
Our study identified potential famciclovir AE signals, providing references for physicians in clinical use to reduce potential side effects and promote safe implementation of the drug in clinical settings.
The Geriatric Nutritional Risk Index is related to adverse hospitalization outcomes in individuals undergoing cardiac surgery
Authors: Zhao Ani , Li Sailan , Liao xiaoqin , Chen liangwan , Lin yanjuan , Wu Lijun , Lin lingyu 
Published: May 2024

Abstract

Malnutrition is linked to adverse outcomes in post-cardiac surgery patients. This study investigates the correlation between GNRI and adverse hospital outcomes in patients following cardiac surgery. This retrospective study included elderly patients with heart disease who were admitted to the Department of Cardiology, Union Hospital Affiliated to Fujian Medical University from January 2020 to December 2022. Patients were divided into two groups based on the cut-off value (98g/dL). Data from 407 patients were assessed, with 278 (68.3%) classified as having nutritional risk and 129 (31.7%) as having no nutritional risk. Notable distinctions were observed in body weight, BMI, and left ventricular ejection fraction (P < 0.05). Laboratory indicators indicated lower levels of serum albumin, lymphocytes, red blood cells, hemoglobin, admission blood glucose, and admission triglyceride in the nutritional risk group (P < 0.05). Neutrophils and serum creatinine were higher in the nutritional risk group (P < 0.05). Poor prognosis was prevalent in the nutrition risk group (64.7%), with higher incidences of adverse outcomes (P < 0.05). Univariate and multivariate studies showed that GNRI < 98 was an independent predictor of postoperative cardiac surgery. Nutritional risk was an important predictor of postoperative adverse hospital outcomes.
Integrated scheduling algorithm with Dynamic Adjustment on Machine Idle Time
Authors: Zhou Wei , Ding Xueying , Xie Zhiqiang , Sun Ming , Tan Zhenjiang 
Published: May 2024

Abstract

During the scheduling of the production of small batch and multi-variety products with treelike structure, many devices are idle due to the process constraints. This increases the makespan of production and reduces the utilization rate of the equipment. Aiming at improving this situation, a resource cooperative scheduling algorithm is proposed to dynamically adjust the idle time of equipment: the integrated scheduling algorithm with dynamic adjustment on machine idle time(ISA_DA). This algorithm adopts the critical path chain and the optimal scheduling strategy. Besides, the adjustment strategy considering the backward movement of the process is put forward to improve the intensity of the close connection of the process and the intensity of parallel processing. Experimental results show that the effect of the proposed algorithm is better than the comparison algorithms: the hierarchical scheduling order algorithm and the process tree cyclic decomposition algorithm. It can increase the equipment utilization rate by 10% and 11.5% respectively, and reduce the makespan by 28.6%.
SGLT-2 inhibitors in chronic peritoneal dialysis patients: a follow-up study
Authors: Lai Jia-Wen , Wang Charles C.N. , Chou Che-Yi 
Published: May 2024

Abstract

Background
Sodium-glucose transporter-2 inhibitors (SGLT-2i) are recommended for use in patients with type 2 diabetes comorbid atherosclerotic cardiovascular disease, heart failure or chronic kidney disease. Limited reports are currently available for their use in dialysis patients. We reported clinical characteristics of chronic peritoneal dialysis (PD) patients on SGLT-2 inhibitors in a follow-up study.
Methods
We enrolled 50 diabetic chronic PD patients, and 11 continued SGLT-2i after PD treatment. We reported the patients' ultrafiltration, HbA1c, urinary tract infection episodes, and venous CO2 during follow-up and compared the differences in these factors between patients with and without SGLT-2i.
Results
The mean age of the patients was 65 ± 15 years, and 16 (32%) patients were female. The age, gender, heart failure, and primary kidney disease were not different between patients with and without SGLT-2i at enrollment. In an average of 31 months follow-up, patients with SGLT-2i had a higher ultrafiltration (1322 ± 200 ml/day vs 985 ± 415 ml/day, p = 0.013), hemoglobin (11.2 ± 1.7 vs 10.2 ± 1.7 g/dl), a lower venous CO2 (p = 0.036). The urine amount, the overall survival, the technical survival, and the chance of UTI were not different between patients with and without SGLT2i.
Conclusion
SGLT-2i may increase ultrafiltration volume and hemoglobin levels in chronic PD patients. The use of SGLT-2i did not increase urinary tract infection but was linked to subclinical metabolic acidosis.