bluuebunny/crossref_metadata_2025_split huggingface dataset:
Loss of copy numbers of retrotransposons (HERVK) on chromosome 7p11.2 impacts EGFR (Epidermal Growth Factor Receptor)‐induced phenotypes for platinum sensitivity and long‐term survival in ovarian cancer—A study from the OVCAD consortium
Authors: Fromhage Gesa , Obermayr Eva , Bednarz‐Knoll Natalia , Van Gorp Toon , Welsch Eva , Polterauer Stephan , Braicu Elena Ioana , Mahner Sven , Sehouli Jalid , Vergote Ignace , Concin Nicole , Kurtz Stefan , Steinbiss Sascha , Torge Antje , Zeillinger Robert , Wölber Linn , Brandt Burkhard 
Published: May 2024

AbstractWe analyzed variations in the epidermal growth factor receptor (EGFR) gene and 5′‐upstream region to identify potential molecular predictors of treatment response in primary epithelial ovarian cancer. Tumor tissues collected during debulking surgery from the prospective multicenter OVCAD study were investigated. Copy number variations in the human endogenous retrovirus sequence human endogenous retrovirus K9 (HERVK9) and EGFR Exons 7 and 9, as well as repeat length and loss of heterozygosity of polymorphic CA‐SSR I and relative EGFR mRNA expression were determined quantitatively. At least one EGFR variation was observed in 94% of the patients. Among the 30 combinations of variations discovered, enhanced platinum sensitivity (n = 151) was found dominantly with HERVK9 haploidy and Exon 7 tetraploidy, overrepresented among patients with survival ≥120 months (24/29, p = .0212). EGFR overexpression (≥80 percentile) was significantly less likely in the responders (17% vs. 32%, p = .044). Multivariate Cox regression analysis, including age, FIGO stage, and grade, indicated that the patients' subgroup was prognostically significant for CA‐SSR I repeat length <18 CA for both alleles (HR 0.276, 95% confidence interval 0.109–0.655, p = .001). Although EGFR variations occur in ovarian cancer, the mRNA levels remain low compared to other EGFR‐mutated cancers. Notably, the inherited length of the CA‐SSR I repeat, HERVK9 haploidy, and Exon 7 tetraploidy conferred three times higher odds ratio to survive for more than 10 years under therapy. This may add value in guiding therapies if determined during follow‐up in circulating tumor cells or circulating tumor DNA and offers HERVK9 as a potential therapeutic target.
Syphilis in pregnancy and adverse birth outcomes: A nationwide longitudinal study in Brazil
Authors: da Silva Helena Benes Matos , de Cássia Ribeiro‐Silva Rita , Junior Elzo Pereira Pinto , Barreto Maurício L. , Paixão Enny S. , Ichihara Maria Yury 
Published: May 2024

AbstractObjectiveThe present study aimed to evaluate the association between syphilis in pregnancy and low birth weight, small for gestational age, and preterm birth.MethodsThis longitudinal study used Brazilian National Information System for livebirths (SINASC) linked to the gestational syphilis cases from Notifiable Diseases Information System (SINAN) from 2011 to 2017. Descriptive statistics and logistic regression were used to compare the birth outcomes of pregnant women with and without syphilis. The study protocol was approved by the Research Ethics Committee of the Institute of Collective Health of the Federal University of Bahia (CAAE: registration no. 18022319.4.0000.5030).ResultsA total of 17 930 817 live births were included in the study. Of these, 155 214 (8.7/1000) were exposed to syphilis during pregnancy. Maternal syphilis increased the odds of low birth weight (aOR 1.88, 95% CI: 1.85–1.91), small for gestational age (aOR 1.53, 95% CI: 1.51–1.56), and preterm birth (aOR 1.35, 95% CI: 1.33–1.37). Higher odds were observed for pregnant women with VDRL titer ≥64 and untreated maternal syphilis when compared to mothers without syphilis. Analysis stratified by prenatal care showed higher odds for all adverse birth outcomes for mothers attending ≤6 prenatal appointments.ConclusionOur findings showed a strong association between gestational syphilis and adverse birth outcomes with increased odds observed among women with higher VDRL titers, lack of treatment, and fewer prenatal appointments. These results highlight the need for adequate screening and treatment for gestational syphilis during pregnancy to mitigate the risk of adverse birth outcomes.
Reviving forgotten techniques: Vaginal salpingectomy in public health system, a retrospective cohort study
Authors: Feldman Micaela Agustina Rosa , Sänger Ileana Verónica , Santilli Ana Lucía , Sarsotti Carlos José , Izbizky Gustavo Hernán 
Published: May 2024

AbstractObjectiveTo evaluate the viability of the vaginal route as an alternative to laparoscopy for patients seeking permanent surgical contraception.MethodsWe conducted a retrospective cohort study in 2021, dividing patients into two groups based on their preference: vaginal and laparoscopic salpingectomy. The statistical analysis was conducted using STATA, employing standard statistical methods based on the distribution of variables.ResultsThe study included 64 patients, with 34 undergoing the vaginal approach and 30 the laparoscopic route. No statistically significant differences were observed in baseline characteristics or complications between the two groups. Both surgical methods were found to be feasible. The vaginal route demonstrated a significantly shorter mean surgical time (P < 0.001). The laparoscopic route exhibited significantly less intraoperative blood loss (P < 0.001) and fewer hospitalization hours (P = 0.008). Postoperative satisfaction and pain levels did not show statistically significant differences.ConclusionVaginal salpingectomy is a feasible technique with low complication rates, making it a potential option for gynecologists to offer their patients. We propose vaginal route inclusion in the training curriculum for gynecologic surgeons during the residency program, without any subspecialty requirements.
Intelligent detection of left ventricular hypertrophy from pediatric echocardiography videos
Authors: Liu Yiman , Han Xiaoxiang , Liang Tongtong , Chen Lijun , Dong Bin , Yuan Jiajun , Wang Hansong , Zhang Zhifang , Zhao Liebin , Zhang Yuqi 
Published: May 2024

AbstractLeft ventricular hypertrophy (LVH) is a common clinical manifestation associated with cardiovascular adverse events. Relying solely on the subjective judgment, it is challenging to promptly and accurately diagnose mild LVH. Quantitatively measuring the interventricular septum and left ventricular posterior wall to diagnose mild LVH is a time‐consuming and labor‐intensive process that is prone to errors. To propose a novel method for rapid and automatic end‐to‐end diagnosis of mild LVH. We propose a novel end‐to‐end automated method for detecting mild LVH. This method achieves rapid end‐to‐end detection of mild LVH in echocardiographic videos without the need for quantitative measurements. Initially, representative frames are extracted from echocardiographic videos, and these frames are then automatically diagnosed by the proposed network to detect LVH. The network architecture primarily consists of three key components: a feature extractor, bidirectional LSTM, and attention module. The Vit‐b model achieved 88% video classification accuracy in the experiment where 32 frames are extracted, and the ViT‐l model achieves 92% video classification accuracy in the experiment where 16 frames are extracted. It is shown experimentally that extracting fewer video frames can diagnose LVH more accurately. The experiments illustrate the superior performance and competitiveness of this method compared to other approaches, potentially applicable to the clinic.
Comparison of peripheral blood automated hematopoietic progenitor cell count and flow cytometric CD34+ cell count
Authors: Hagenkötter Mischa , Mika Thomas , Ladigan‐Badura Swetlana , Schork Karin , Eisenacher Martin , Schroers Roland , Baraniskin Alexander 
Published: May 2024

AbstractBackgroundStem cell apheresis in the context of autologous stem cell transplantation requires an accurate cluster of differentiantion 34 (CD34+) count determined by flow cytometry as the current gold standard. Since flow cytometry is a personnel and time‐intensive diagnostic tool, automated stem cell enumeration may provide a promising alternative. Hence, this study aimed to compare automated hematopoietic progenitor enumeration carried out on a Sysmex XN‐20 module compared with conventional flow cytometric measurements.MethodsOne hundred forty‐three blood samples from 41 patients were included in this study. Correlation between the two methods was calculated over all samples, depending on leukocyte count and diagnosis.ResultsOverall, we found a high degree of correlation (r = 0.884). Furthermore, correlation was not impaired by elevated leukocyte counts (>10 000/μL, r = 0.860 vs <10 000/μL, r = 0.849; >20 000/μL, r = 0.843 vs <20 000/μL, r = 0.875). However, correlation was significantly impaired in patients with multiple myeloma (multiple myeloma r = 0.840 vs nonmyeloma r = 0.934).SummaryStem cell measurement carried out on the Sysmex XN‐20 module provides a significant correlation with flow cytometry and might be implemented in clinical practice. In clinical decision‐making, there was discrepancy of under 15% of cases. In multiple myeloma patients, XN‐20 should be used with caution.
A case of primary breast angiosarcoma diagnosed by multimodal ultrasound imaging with literature review
Authors: Lin Minhao , Xu Xiaohong , Dai Haixia , Huang Qiuxia , Liu Lijuan 
Published: May 2024

AbstractPrimary Breast Angiosarcoma (PBA) is an exceptionally rare form of breast cancer, accounting for less than 0.05% of all breast cancers. It is characterized by a high level of malignancy, invasiveness, and has a prognosis that is typically poor. The lack of distinctive clinical features makes it prone to underdiagnosis and misdiagnosis. This study retrospectively examines a case utilizing multimodal ultrasound imaging techniques (including 2D ultrasound, contrast‐enhanced ultrasound, and ultrasound elastography) for diagnosing PBA. Furthermore, the study reviews relevant literature to summarize the ultrasound characteristics of PBA, with the aim of improving understanding of this elusive condition.
The effect of seed layer cycles on the structural, optical, and morphological properties of ZnO nanorods
Authors: Oke‐Altuntas Feyza , Saritan Selin , Colak Hakan 
Published: May 2024

AbstractIn this study, ZnO seed layers with different cycles were formed on glass substrates by the sol–gel technique, and ZnO nanorods were grown on them by the hydrothermal method. Morphology and the structural characterization of the seed films and the ZnO nanorods are carried out by field emission scanning electron microscopy (FE‐SEM) and x‐ray diffraction techniques. In addition, to investigate the effect of seed layer deposition cycles on the optical properties of the ZnO nanorod arrays, UV/visible spectrophotometer and photoluminescence (PL) measurements were performed. The changes in structural and optical parameters such as dislocation density, strain, crystallite size, and optical band gap values on each seed layer deposition cycle were examined. The highest optical band gap and crystallite size were obtained for ZnO nanorods with 4 cycles seed layer as 3.22 eV and 63.6 nm, respectively. Also, in the PL spectrum, the largest ratio of UV‐emission region to weak‐visible emission region was obtained in ZnO nanorods having 4 cycles. In addition, the glucose detection properties of ZnO nanorods having 4 cycles were investigated using the PL measurements and it was found that UV‐emission peak intensity of ZnO nanorods decreased as the glucose concentration increased from 8 to 40 mM. The results show that the number of deposition cycles of the seed layer has a strong influence on the orientation, crystal quality, and optical band gap of the growing ZnO nanorods, as well as significantly affecting their morphological properties.Research Highlights
High quality ZnO nanorods were grown on glass substrates by hydrothermal method.
The effect of ZnO seed layer cycles on the structural, optical, and morphological characteristics of ZnO nanorods grown on were examined.
It was found that the number of cycles of the seed layer is a critical parameter for growing quality and well‐aligned ZnO nanorods.
How do humble leaders unleash followers' leadership potential? The roles of workplace status and individualistic orientation
Authors: Lin Xiaoshuang , Tse Herman H. M. , Shao Bo , Duan Jinyun 
Published: May 2024

SummaryWhile leader‐expressed humility has received an upsurge in attention in recent years, a fundamental issue that remains unaddressed is whether leader‐expressed humility, as a bottom–up leadership approach, could indeed elevate followers' workplace status and eventually unleash their leadership potential; if so, how and when? Drawing on expectation states theory (EST) and using two multi‐wave datasets, including one from 216 one‐to‐one matched supervisor–subordinate dyads in China (Study 1) and the other from 210 subordinates in Western countries (Study 2), we provide evidence that leader humility is effective in elevating followers' workplace status, particularly when followers' individualistic orientation is high. This elevated perception of workplace status also increases followers' leadership potential, demonstrated by their motivation to lead and taking charge behaviors. These findings offer novel theoretical and practical insights into the implications of leader humility for followers' leadership potential.
Inflammation and tissue remodeling mediator expression during gingivitis: A comparison between experimental, naturally occurring gingivitis, and periodontal health
Authors: Hsu Yung‐Ting , Chang Ana M. , Daubert Diane , Roberts Frank , Chen Dandan , Trivedi Harsh M. , Gomez Juliana , Darveau Rich P. 
Published: May 2024

AbstractBackgroundThe aim of this study is to evaluate the immune regulation and tissue remodeling responses during experimental gingivitis (EG) and naturally occurring gingivitis (NG) to provide a comprehensive analysis of host responses. Gingival crevicular fluid (GCF) was obtained from 2 human studies conducted in university settings.MethodsThe EG study enrolling 26 volunteers provided controls for the baseline (Day 0) from healthy disease‐free participants, while Day 21 (the end of EG induction of the same group) was used to represent EG. Twenty‐six NG participants age‐matched with those of the EG group were recruited. GCF samples were analyzed for 39 mediators of inflammatory/immune responses and tissue remodeling using commercially available bead‐based multiplex immunoassays. The differences in GI and mediator expression among groups were determined at a 95% confidence level (p ≤ 0.05) by a 2‐way analysis of variance (ANOVA) with a post‐hoc Tukey's test.ResultsOur findings showed that EG had a greater gingival index than NG and was healthy (p < 0.01 of all comparisons). Furthermore, EG showed significantly higher levels of MPO (p < 0.001), CCL3 (p < 0.05), and IL‐1B (p < 0.001) than NG. In contrast, NG had increased levels of MIF (p < 0.05), Fractalkine (p < 0.001), angiogenin (p < 0.05), C3a (p < 0.001), BMP‐2 (p < 0.001), OPN (p < 0.05), RANKL (p < 0.001), and MMP‐13 (p < 0.001) than EG.ConclusionsConsistent with the findings from chronic (NG) versus acute (EG) inflammatory lesions, these data reveal that NG displays greater immune regulation, angiogenesis, and bone remodeling compared to EG.
Angiogenic potential in periodontal stem cells from upper and lower jaw: A pilot study
Authors: Malyaran Hanna , Radermacher Chloé , Craveiro Rogerio B. , Kühnel Mark P. , Jonigk Danny , Wolf Michael , Neuss Sabine 
Published: May 2024

AbstractBackgroundTeeth and supporting oral tissues are attractive and accessible sources of stem cells. Periodontal ligament stem cells (PDLSC) are readily isolated from extracted third molars, and exhibit the ability to self‐renew and differentiate into multiple mesodermal cell fates. Clinical experience suggests that the exact location of periodontal defects affects the oral bone remodeling and wound healing. Compared to the mandible, the maxilla heals quicker and more efficiently. Angiogenesis is key in tissue regeneration including dental tissues, yet few studies focus on the angiogenic potential of PDLSC, none of which considered the differences between upper and lower jaw PDLSC (u‐PDLSC and l‐PDLSC, respectively).MethodsHere we studied the angiogenic potential of u‐PDLSC and l‐PDLSC and compared the results to well‐established mesenchymal stem cells (MSC). Cells were characterized in terms of surface markers, proliferation, and vascular endothelial growth factor (VEGF) secretion, and angiogenic assays were performed. Newly formed capillaries were stained with CD31, and their expression of platelet endothelial cell adhesion molecule (PECAM‐1), angiopoietin 2 (ANGPT2), and vascular endothelial growth factor receptor 1 and 2 (VEGFR‐1, VEGFR‐2) were measured.ResultsPeriodontal stem cells from the upper jaw showed a higher proliferation capacity, secreted more VEGF, and formed capillary networks faster and denser than l‐PDLSC. Gene expression of angiogenesis‐related genes was significantly higher in u‐PDLSC than in l‐PDLSC or MSC, given that culture conditions were suitable.ConclusionThe oral cavity is a valuable source of stem cells, particularly PDLSC, which are promising for oral tissue engineering due to their robust growth, lifelong accessibility, low immunogenicity, and strong differentiation potential. Notably, u‐PDLSC exhibit higher VEGF secretion and accelerate capillary formation compared to l‐PDLSC or MSC. This study suggests a potential molecular mechanism in capillary formation, emphasizing the significance of precise location isolation of PDLSC.
Antibiotic duration and gastric dysmotility in preterm neonates
Authors: Sadder Liane Samira , Brown Larry Steven , Roblyer Lindsay , Sanghavi Rinarani , Ortigoza Eric Brum 
Published: May 2024

AbstractObjectivesProlonged antibiotic use after birth is associated with neonatal feeding intolerance and functional gastrointestinal disorders (FGIDs). A gastric dysrhythmia (tachygastria) with frequencies >4–9 cycles per minute, measured by electrogastrography (EGG), is associated with FGIDs. The relationship between prolonged antibiotic use and % time spent in tachygastria is unknown in preterm infants. We aimed to compare weekly changes in % tachygastria between preterm infants receiving long (>48 h) versus short (≤48 h) courses of antibiotics for early onset sepsis evaluation (initiated at <3 days of life).MethodsThis was a longitudinal, prospective cohort study of 88 preterm infants (<34 weeks' gestation) with weekly EGG recordings from the first week of life until 40 weeks' post‐menstrual age, discharge, or death. We calculated % of EGG recording time in tachygastria and determined the mean across weekly sessions. A mixed effects model assessed variance in % tachygastria between the short‐ and long‐antibiotic exposure groups across all weeks.ResultsBaseline characteristics were similar between the two groups. There was no difference in % tachygastria between short and long antibiotic exposure groups across nine postnatal weeks (p = 0.08).ConclusionsEarly, prolonged antibiotic exposure among preterm infants may not lead to significant gastric dysrhythmia. Future studies including larger sample sizes and a “no antibiotic” exposure arm are essential in elucidating this potential relationship.
Multi‐Wavelength Metasurface Empowered Cryptography for Heightened Security and Improved Fidelity
Authors: Gu Zhen , Liu Haoyang , Zhang Zhengping , Wang Xiong , Zhang Hualiang , Gao Jianjun , Si Liming , Ding Jun 
Published: May 2024

AbstractInformation security holds paramount importance in the contemporary information society. Here, a novel cryptography method is proposed based on the multi‐wavelength complex‐amplitude metasurface, which can achieve a high security level by generating a frequency‐selective key as an additional layer of protection. Moreover, the quality of the decrypted holographic images can be significantly improved by employing the complex‐amplitude encoding method and the modified visual secret sharing scheme, which adopts a new superposition operator to prevent fidelity loss. As a proof‐of‐concept demonstration, a prototype metasurface sample is designed, fabricated, and characterized, where the measured results agree very well with the numerical ones and the design goals. The proposed method can reinforce security level and improve fidelity of the decrypted message, rendering it appealing for applications in communication and anti‐counterfeiting.
OPTIMAL LEADERSHIP AND EMOTIONAL INTELLIGENCE
Authors: Goleman Daniel , Cherniss Cary 
Published: May 2024

AbstractDaniel Goleman is best known as the psychologist/author who brought the concept of emotional intelligence (EI) to a wider audience in the mid‐1990s. His coauthor Cary Cherniss was a founding member of the Consortium for Research on Emotional Intelligence in Organizations (CREIO), where he served as its director and co‐chair for 25 years. They note that when they co‐founded CREIO “more than 25 years ago, there was sparse evidence for the role of EI in optimal leading. Now there is substantial data from studies of hundreds of organizations that reveal a wide range of benefits when leaders, teams, and employees embody EI.” The authors further state that “the impact of a leader’s emotional intelligence goes beyond business performance to include optimal well‐being. For example, information‐technology employees working at a large medical facility who had more empathic managers reported fewer complaints like headaches and upset stomachs.” They provide numerous workplace examples to back up their research, and acknowledge the research of others such as Richard Boyatzis and his team at Case Western Reserve University and Jean Decety at the University of Chicago on the importance of empathy and the three types Decety has found: cognitive, emotional; and empathic concern.
Base‐Filling in Double‐Helical Nucleic Acids
Authors: Afari Mark Nana Kwame , Lönnberg Tuomas 
Published: May 2024

AbstractBase‐filling, i. e., post‐synthetic furnishing of an oligonucleotide scaffold with base moieties or their analogues, is an interesting alternative to the conventional approach of sequential coupling of building blocks (modified or otherwise). Reversible attachment of the base moieties is particularly attractive as it allows the use of dynamic combinatorial chemistry and usually leads to higher fidelity. This concept article summarizes the various backbones and coupling reactions used for base‐filling over the past fifteen years, discusses the impact of base stacking and pairing on efficiency and fidelity and highlights potential and realized applications.