bluuebunny/crossref_metadata_2025_split huggingface dataset:
Earthquake-induced snow avalanches: II. Experimental study
Authors: Podolskiy Evgeny A. , Nishimura Kouichi , Abe Osamu , Chernous Pavel A. 
Published: September 2010

AbstractWe conducted experiments on the stability of snow, subjecting snow to vibrations, with the aim of improving our understanding of poorly studied mechanisms behind the triggering of avalanches during earthquakes. Most experiments were carried out on a specially constructed shaking table using artificial snowpacks containing a weak layer. Accelerations in the snow samples were measured using high-frequency sensors, enabling calculation of vibration-induced stresses within the snow at the moment of fracture. We used a high-speed camera to film different types of fracturing. In all cases, the vibrations caused failure of the snow by fracturing along the weak layer or at the base of the snow sample. An additional inertial stress induced by accelerations normal to the shear plane was quantified. We find that this stress can be related to smaller values of the shear strength in snow.
Early Glasgow Sugar Plantations in the Caribbean
Authors: Nisbet Stuart M. 
Published: September 2010

From the 17th century, Glasgow grew from a local market centre to a merchant city. Much of the wealth of its leading merchants came from Atlantic trade. Before the city's celebrated connections with Virginia, great success was achieved from trade with the Caribbean. In the late 17th century, Glasgow had more than a hundred merchants, part of a ‘Great Company’ trading with the Americas, including the Caribbean islands. 1 This was a two-way process, and various Glasgow pioneers operated at the colonial end. This article explores the hitherto hidden background of two of the city's earliest and most successful Caribbean merchants. This is achieved by an investigation of the upstanding archaeology on their sugar plantations on the Leeward Island of St Kitts (St Christopher). It will suggest that to put Glasgow's development in proper context, we must consider this neglected part of its history and archaeology.
The LupusQoL and Associations with Demographics and Clinical Measurements in Patients with Systemic Lupus Erythematosus
Authors: McELHONE KATHLEEN , CASTELINO MADHURA , ABBOTT JANICE , BRUCE IAN N. , AHMAD YASMEEN , SHELMERDINE JOANNA , PEERS KATE , ISENBERG DAVID , FERENKEH-KOROMA ADA , GRIFFITHS BRIDGET , AKIL MOHAMMED , MADDISON PETER , GORDON CAROLINE , TEH LEE-SUAN 
Published: September 2010

Objective.Having developed and validated a disease-specific health-related quality of life (HRQOL) measure for patients with systemic lupus erythematosus (SLE), the LupusQoL, we determined its relationship to demographic and clinical measurements in a group of patients with SLE.Methods.A group of 322 outpatients completed the LupusQoL. Demographic (age, sex, marital status, ethnicity) and clinical variables (disease duration, disease activity, damage) were recorded. Associations between the 8 LupusQoL domains and age, disease duration, disease activity, and damage were explored using Spearman’s correlation coefficients. Differences in LupusQoL scores were examined for sex and marital status using the Mann-Whitney U test. Ethnic groups were compared using ANOVA.Results.All domains of LupusQoL were impaired, with fatigue (56.3) being the worst affected and body image (80.0) the least. The correlations between the LupusQoL domain scores and age (r = −0.01 to −0.22) and disease duration (r = 0 to 0.16) were absent or weak. Similarly, there were no significant differences in the LupusQoL scores regarding sex, marital status, or the 3 main ethnic groups (Black-Caribbean, Asian, White). Although there were statistically significant correlations between the scores of the LupusQoL domains and some scores of the British Isles Lupus Assessment Group index (r = −0.22 to 0.09) and the Systemic Lupus International Collaborating Clinics/American College of Rheumatology Damage Index (r = −0.29 to 0.21), these were weak.Conclusion.HRQOL was impaired in this cohort of outpatients with SLE as assessed by the validated lupus-specific LupusQoL. There were no clinically important associations between the 8 domains of the LupusQoL and clinical or demographic variables in this group of patients. Thus, the LupusQoL is a relatively independent outcome measure in patients with SLE.
Intraarticular Botulinum Toxin A for Refractory Painful Total Knee Arthroplasty: A Randomized Controlled Trial
Authors: SINGH JASVINDER A. , MAHOWALD MAREN L. , NOORBALOOCHI SIAMAK 
Published: September 2010

Objective.To assess short-term efficacy of single intraarticular botulinum toxin (IA-BoNT/A) injection in patients with chronically painful total knee arthroplasty (TKA) in a randomized, placebo-controlled, triple-blind study.Methods.Patients with chronic TKA pain (pain > 6 on 0–10 scale and > 6 months post-TKA) evaluated in and referred from orthopedic surgery clinics were recruited. The primary outcome, proportion of patients with clinically meaningful decrease of at least 2 points on 0–10 visual analog scale (VAS) for pain, was compared between treatment groups at 2 months using comparison of proportions test and for all efficacy timepoints (2, 3, and 4 months) using generalized estimating equations (GEE). Secondary outcomes of global assessment, function, and quality of life were compared using GEE, duration of pain relief by t-test, and adverse events by chi-square test.Results.In total, 54 patients with 60 painful TKA were randomized, with main analyses restricted to one TKA per patient (49 TKA in 49 patients). Mean age was 67 years, 84% were men, and mean duration of TKA pain was 4.5 years. A significantly greater proportion of patients (71%) in the IA-BoNT/A group compared to IA-placebo (35%) achieved clinically meaningful reduction in VAS pain at 2 months (p = 0.028) and at all efficacy timepoints (p = 0.019). Duration of meaningful pain relief was significantly greater after IA-BoNT/A, 39.6 days (SD 50.4) compared to IA-placebo, 15.7 days (SD 22.6; p = 0.045). Statistically significantly better scores were seen in IA-BoNT/A vs IA-placebo for all efficacy timepoints for the following outcomes: “very much improved” on physician global assessment of change (p = 0.003); Western Ontario McMaster Osteoarthritis Index physical function (p = 0.026), stiffness (p = 0.004), and total scores (p = 0.024); and Short-Form 36 pain subscale score (p = 0.049). Number of total and serious adverse events was similar between groups, with no patients in either group with new objective motor or sensory deficits during followup.Conclusion.In this single-center randomized trial, single IA-BoNT/A injection provided clinically meaningful short-term improvements in pain, global assessment, and function in patients with chronic painful TKA. A multicenter trial is needed to confirm these findings.
Langage et métaphysique chez Heidegger et chez Wittgenstein
Authors: Dastur Françoise 
Published: September 2010

Résumé On se propose ici de tenter de rapprocher la critique wittgensteinienne des propositions métaphysiques du projet heideggérien de « destruction phénoménologique de l’histoire de l’ontologie ». Il s’agit donc d’abord de rappeler que dans le Tractatus Wittgenstein établit une différence « transcendantale » entre ce qui peut se dire (les propositions sensées) et ce qui ne fait que « se montrer » et qu’il faut plutôt taire (les propositions dépourvues de sens de la métaphysique). Mais chez Wittgenstein la mise en évidence de cette différence conduit au refus du métalangage, et à l’interdiction d’une interrogation sur sa propre démarche de philosophe, c’est-à-dire à ce que l’on pourrait nommer un « transcendantalisme paradoxal ». Chez Heidegger en revanche la mise en évidence de la différence ontologique, laquelle ne permet ni de faire de l’être un prédicat réel ni d’énoncer l’être sous la forme de propositions prédicatives conduit à interroger le fondement antéprédicatif du langage énonciatif (du logos apophantikos aristotélicien), qui n’est autre que la transcendance du Dasein. Il répond ainsi à la paradoxie du Tractatus en montrant qu’il n’y a d’ apophansis que sur la base d’une hermeneia plus originaire. Une mise en parallèle de l’« herméneutique de la facticité » heideggérienne et de l’analyse wittgensteinienne des jeux de langage en tant que formes de vie peut alors être tentée, dans la mesure où la dimension herméneutique du comprendre n’est pas entièrement absente chez le second Wittgenstein, en dépit de sa conception instrumentale du langage.
« La philosophie ne doit en aucune manière porter atteinte à l'usage effectif du langage »
Authors: Ehrsam Raphaël 
Published: September 2010

Résumé Le rapport de la philosophie à l’usage doit-il s’en tenir à la description ? Que signifie l’exigence descriptive elle-même ? On éclaire ces questions depuis les modes d’approche de l’usage que la description promeut et interdit.
An Alternative Role of C1q in Cell Migration and Tissue Remodeling: Contribution to Trophoblast Invasion and Placental Development
Authors: Agostinis Chiara , Bulla Roberta , Tripodo Claudio , Gismondi Angela , Stabile Helena , Bossi Fleur , Guarnotta Carla , Garlanda Cecilia , De Seta Francesco , Spessotto Paola , Santoni Angela , Ghebrehiwet Berhane , Girardi Guillermina , Tedesco Francesco 
Published: September 2010

Abstract
Fetal trophoblast cells invading the decidua in the early phase of pregnancy establish complex interaction with the maternal extracellular matrix. We discovered that C1q was widely distributed in human decidual stroma in the absence of C4 and C3 and was actively synthesized by migrating extravillous trophoblasts. The cells expressed the messages for the three chains of C1q and secreted this complement component that interacted with the proteins of the decidual extracellular matrix. Solid phase-bound C1q promoted trophoblast adhesion and migration, and cell binding to C1q resulted in activation of ERK1/2 MAPKs. Ab inhibition experiments showed that the receptors for the globular head of C1q/p33 and α4β1 integrin were both involved in this process and were colocalized on the cell surface following binding of C1q to trophoblasts. We also found that C1q−/− mice manifested increased frequency of fetal resorption, reduced fetal weight, and smaller litter sizes compared with wild-type mice. C1q deficiency was associated with impaired labyrinth development and decidual vessel remodeling. Collectively, these data suggest that C1q plays an important role in promoting trophoblast invasion of decidua and that defective local production of C1q may be involved in pregnancy disorders, such as pre-eclampsia, characterized by poor trophoblast invasion.
Cell‐Based Hepatitis C Virus Infection Fluorescence Resonance Energy Transfer (FRET) Assay for Antiviral Compound Screening
Authors: Yu Xuemei , Uprichard Susan L. 
Published: September 2010

AbstractHepatitis C virus (HCV) affects an estimated 3% of the population and is a leading cause of chronic liver disease worldwide. Since HCV therapeutic and preventative options are limited, the development of new HCV antivirals has become a global health care concern. This has spurred the development of cell‐based infectious HCV high‐throughput screening assays to test the ability of compounds to inhibit HCV infection. This unit describes methods that may be used to assess the in vitro efficacy of HCV antivirals using a cell‐based high‐throughput fluorescence resonance energy transfer (FRET) HCV infection screening assay, which allows for the identification of inhibitors that target HCV at any step in the viral life cycle. Basic protocols are provided for compound screening during HCV infection and analysis of compound efficacy using an HCV FRET assay. Support protocols are provided for propagation of infectious HCV and measurement of viral infectivity. Curr. Protoc. Microbiol. 18:17.5.1‐17.5.27. © 2010 by John Wiley & Sons, Inc.
Whole embryo culture: a “New” technique that enabled decades of mechanistic discoveries
Authors: Ellis‐Hutchings Robert G. , Carney Edward W. 
Published: September 2010

AbstractDenis New's development of the rodent whole embryo culture (WEC) method in the early 1960s was a groundbreaking achievement that gave embryologists and teratologists an unprecedented degree of access to the developing postimplantation rodent embryo. In the five decades since its development, WEC has enabled detailed investigations into the regulation of normal embryo development as well as a plethora of research on mechanisms of teratogenesis as induced by a wide range of agents. In addition, WEC is one of the few techniques that has been validated for use in teratogenicity screening of drugs and chemicals. In this review, we retrace the steps leading to New's development of WEC, and highlight many examples in which WEC played a crucial role leading to important discoveries in teratological research. The impact of WEC on the field of teratology has been enormous, and it is anticipated that WEC will remain a preferred tool for teratologists and embryologists seeking to interrogate embryo development for many years to come.Birth Defects Res (Part B)89:304–312, 2010. © 2010 Wiley‐Liss, Inc.
New Strategies for e‐Beam Characterization of Catalysts
Authors: Howie A. 
Published: September 2010

AbstractBuilding on the success of aberration correction and the construction of in situ reaction chambers, electron microscopy is poised to make fresh advances in catalyst characterization. More profitable use should be made of photons both as input drivers and as output signals. Secondary electron imaging can provide extra information about the support structure. When collected in coincidence with primary beam energy losses, the secondary electron signal may even open the way to surface barrier height measurement at surface facets on individual nanoparticles.
Application of EEM fluorescence in combination with PARAFAC analysis to simultaneously monitor quercetin in its deprotonated, aggregated, and protein bound states
Authors: Simpson John V. , Burke Marissa , Jiji Renee D. 
Published: September 2010

AbstractFlavonoids, a group of naturally occurring polyphenols, attract great interest due to their many apparent health benefits including their anti‐oxidant properties and anti‐amyloidogenic properties. However, the behavior of flavonoids in aqueous environments can be unpredictable due to the potential formation of aggregates and hydrolysis products. A better understanding of the complex behavior of flavonoids is needed before flavonoid‐based therapies can be developed. Employing excitation–emission matrix (EEM) fluorescence in combination with weighted‐parallel factor analysis (WPARAFAC), a series of aqueous quercetin solutions were characterized at varying pH values and concentrations. Distinct pH and concentration‐dependent fluorophores were observed with emission maxima of 540 and 600 nm, respectively. However, the excitation maxima of the two species were broad and highly overlapped ranging from 350 to 400 nm. In addition, the fluorescence of quercetin was characterized in the presence and absence of bovine serum albumin (BSA). Interaction with BSA resulted in a dramatic red‐shift of the excitation maximum to 445 nm, while the emission maximum of the BSA–quercetin complex was slightly blue‐shifted to 535 nm. Coupling of WPARAFAC and EEM fluorescence enabled simultaneous detection of multiple fluorescent quercetin species in solution at a wide range of conditions. Copyright © 2010 John Wiley & Sons, Ltd.
ChemInform Abstract: Oligodeoxynucleotide Synthesis. H‐Phosphonate Approach
Authors: FROEHLER B. C. 
Published: September 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Valiolamine and Its N‐Substituted Derivatives. α‐D‐Glucosidase Inhibitors. From Validamycins to Voglibose (AO‐128), and Antidiabetic Agents
Authors: HORII S. 
Published: September 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Structure of a Sodium‐Substituted Palladium Hydride, NaPd3H2.
Authors: KADIR K. , NOREUS D. 
Published: September 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Concepts of Sterically Hindered Resonance and Buttressing Effect: Gas‐ Phase Acidities of Methyl‐Substituted Benzoic Acids (I)‐(IV) and Basicities of Their Methyl Esters
Authors: DECOUZON M. , ERTL P. , EXNER O. , GAL J.‐F. , MARIA P.‐C. 
Published: September 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Enantioselective Diels‐Alder Reaction of α‐Bromo α,β‐ Enals with Dienes Under Catalysis by CAB.
Authors: ISHIHARA K. , GAO Q. , YAMAMOTO H. 
Published: September 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis and Polymerization of Monomeric α‐Substituted Fluorinated Acrylates. Part 3. Synthesis and Polymerization of Ethyl . alpha.‐(Heptadecafluoroundecanoyl)acrylate
Authors: BESSIERE J. M. , BOUTEVIN B. , EL BACHIRI A. , EL HARFI A. 
Published: September 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Bridgehead Nitrogen Heterocycles. Part 5. Syntheses of s‐Triazolo(3,4‐ b)(1,3,4)benzothiadiazines, s‐Triazolo(3,4‐b)(1,3,4)thiadiazines, s‐ Triazolo(3,4‐b)(1,3,4)thiadiazino(5,6‐b)quinoxaline, Imidazo(2,1‐b) benzothiazole and Benzimidazo(2,1‐b)benzothiazole as Potential Antimicrobial Agents.
Authors: CHADHA V. K. , JOSHI S. , BHARGAVA A. 
Published: September 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Aryl Radical Additions to Aldehydes and Oxime Ethers: The Tandem Enediyne‐Radical Cyclization.
Authors: GRISSOM J. W. , KLINGBERG D. 
Published: September 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Tetramethylene.
Authors: DOUBLEDAY C. JUN. 
Published: September 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Thallium(III) Acetate Oxidation of Some Substituted 4‐Piperidones: A Kinetic and Mechanistic Study.
Authors: MEENAL KR. , LALITHA S. 
Published: September 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Preparation of α‐Halo‐F‐2‐ketones and F‐2‐Ketones via Fluorination of α,α‐Dihalo‐F‐2‐ketones.
Authors: BURTON D. J. , JEONG I. H. 
Published: September 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Sulfur Ylides. Part 5. Reactions of Phthalimido‐Containing Keto‐ Stabilized Sulfonium Ylides.
Authors: LAKEEV S. N. , GALIN F. Z. , KHALILOV L. M. , TOLSTIKOV G. A. 
Published: September 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Selective Synthesis of Bis(1‐propenyl) Sulfone (III) and Bis(1‐ propenyl) Sulfoxide (II).
Authors: AMOSOVA S. A. , MUSORIN G. K. , VITKOVSKII V. YU. 
Published: September 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Amides and Formamidines with Antinociceptive Activity. Part 2.
Authors: PAU A. , BOATTO G. , CERRI R. , PALOMBA M. , NICOLAI M. , SPARATORE F. , VARONI M. V. 
Published: September 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Reactions of Acrylic Acid with Fluoroalkanoyl Peroxides ‐ The Formation of Acrylic Acid Oligomers Containing Two Fluoroalkylated End‐ Groups.
Authors: SAWADA H. , MINOSHIMA Y. , NAKAJIMA H. 
Published: September 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Lactones. Part 24. “γ‐Lactonized” Neuroleptics. Synthesis, Stereochemistry, and Affinity at the D2 Receptor.
Authors: LEHMANN J. , SCHULZE G. , RADWANSKY A. 
Published: September 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.