bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mass spectra of some 1,2,4‐triazine 1‐ and 2‐oxides
Authors: Radel Robert J. , Keen Brian T. , Paudler William W. 
Published: April 2009

AbstractA study of the fragmentation patterns of a variety of substituted 1,2,4‐triazine 1‐ and 2‐oxides has been undertaken. It is shown that the fragmentation patterns of the 1‐ and 2‐oxides are extremely similar with the relative peak intensities varying with the type of substituents present.
Conjugate acid structure for oxaziridines bearing primary and secondary 2‐alky 1 groups
Authors: Challis Brian C. , Lobo Ana M. 
Published: April 2009

AbstractThe protonation of five representative oxaziridines is reported for inert solvents (deuterio‐chloroform or carbon tetrachloride) where conjugate acid formation may be effected by the addition of about 20% (v/v) TFA. Comparison of the 1H nmr chemical shifts for neutral and conjugate acid forms suggests that oxaziridines usually undergo protonation on the N‐atom under these conditions. For one compound studied, 2‐ethyl‐3‐p‐nitrophenyloxaziridine, there is a possibility that protonation occurs on the alternative O‐atom. The relevance of these findings to the mechanism of the acid‐catalysed hydrolysis of oxaziridines is discussed.
13C Nmr analysis of 5‐amino‐1,2,3,4‐thiatriazoles and thiatriazolinethione
Authors: L'Abbé Gerrit , Toppet Suzanne , Willocx André , Mathys Georges 
Published: April 2009

AbstractThe usefulness of 13C nmr spectroscopy in the tautomeric assignment of 5‐(monosubstituted)‐amino‐1,2,3,4‐thiatriazoles is demonstrated. The reaction products, derived therefrom by alkylation, acylation and sulfonylation, are also readily characterized by an inspection of the 13C5 signal shift. For thiatriazolinethione, the 13C nmr spectrum indicates the presence of a thioketone function (6, δ 193.1 ppm) instead of a thiol function (7).
2‐Pyridylenamines via transenamination
Authors: Yale Harry L. , Spitzmiller E. R. 
Published: April 2009

AbstractTransenamination, a reaction apparently not previously described in the literature, has been employed to prepare a series of 2‐pyridylenamines. The products were formed in 11‐78% yield by the reaction of substituted 2‐arninopyridines, 1a‐g, and either methyl 3‐aminocrotonate, 2, or ethyl 3‐aminocinnamate, 3, in anhydrous toluene, under reflux. Data from these reactions would suggest that the reaction rates and consequently, the yields, were adversely affected by substitution that served to decrease the basicity of the amino group in either reactant.
Derivatives of 2‐sulfonamido‐4.5‐dimetlioxyphenylacetic acid and their oxazolines and aminoesters
Authors: Catsoulacos P. , Camoutsis Ch. 
Published: April 2009

AbstractSeries of variously substituted aminoesters and oxazolines of 2‐sulfonamido‐4,5‐clirnethoxy‐phenylacetic acid have been prepared and some of them screened for biological activity.
The origin of syn/anti selectivity in the cycloaddition reactions of 7‐substituted norbornadienes
Authors: Alston P. V. , Ottenbrite R. M. 
Published: April 2009

AbstractGeneralizations which permit the prediction of the syn/anti selectivity in the [π4s + π2s] cyeloadditions of 7‐substituted norbornadienes has been developed from perturbation molecular orbital theory. These theoretical predictions are in excellent agreement with all the experimental results reported in the literature. Furthermore, the effect of the 7‐substituent of norbornenes on the double bond has been explained by the “through‐space” interactions between the substituent and the syn‐double bond.
Carbon‐13 nuclear magnetic resonance spectra of potent antimalarials: Primaquine and chloroquine
Authors: Singh S. P. , Parmar S. S. , Stenberg Virgil I. 
Published: April 2009

AbstractC13 Nmr chemical shits of primaquine and chloroquine are reported. The signals are assigned on the basis of substituent effects on benzene shifts, intensities, multiplicities in SFORI) and the comparison with structurally related compounds.
Cyclic imides. XI. Bisimide charge‐transfer polymers
Authors: Caswell Lyman R. , Palacios Patricia , Schmidt Suzanne J. , Anvar Roya , García Anabel 
Published: April 2009

AbstractCondensation of two equivalents of an aromatic cyclic anhydride with an aromatic diamine, or of two equivalents of an aromatic amine with an aromatic bisanhydride, results in the formation of an aromatic bisimide. Thirty‐one such bisimides were prepared. The bisimides in which the two imide groups arc connected by a fully coplanar system show extremely low solubilities and high melting and decomposition temperatures. Many are also strongly colored. It is suggested that these properties may result from intermolecular charge‐transfer effects in the solid slate, giving charge‐transfer polymers.
Reaction of substituted selenoureas with dimethyl acetylenedicarboxylate
Authors: Shafiee A. , Assadi F. , Cohen V. I. 
Published: April 2009

AbstractMono and 1,3‐disubstituted selenoureas react with dimethyl acetylenedicarboxylate to give in high yield substituted 3,4‐dihydro‐4‐oxo‐2H‐1,3‐selenazines whose structures were established by speclroscopic methods.
The insertion and extrusion of heterosulfur bridges. V. Desulfurization of dibenzothiophene by means of methanol and molybdena catalysts
Authors: Klemm L. H. , Karchesy Joseph J. 
Published: April 2009

AbstractDesuliurization of dibenzothiophene is effected in 82% yield by means of methanol and a sulfidcd cohaltous oxide‐molylxlic oxide‐aluminum oxide catalyst at 450° and ca. one atmosphere pressure in a flow system. The methanol serves as a hydrogen donor and methylating agent to form biphenyl (main product), 3‐ and 4‐methylbiphenyls, and fluorene.
Chemistry of the phenoxathiins. III. Synthesis of benzo[1″,2″:5,6:5″,4″:5′,6′]bis[1,4]oxathiino[3,2‐b:3′,2′‐b']dipyridine
Authors: Martin Gary E. , Turley James C. , Miller Richard F. , Schram Karl H. , Williams Louis 
Published: April 2009

AbstractAs a result of studies dealing with the synthesis of 1‐azaphenoxathiins, the synthesis of benzo[1″,2″:5,6:5″,4″:5′,6′]bis[1,4]oxathiino[3,2‐b:3′,2′‐b']dipyridine was examined. Unique evidence of solvent participation in the synthesis of these compounds by the structure elucidation of a novel minor by‐product formed during the synthesis of the title compound is also reported.
Synthesis of 4H‐furo[3,2‐b]indoles. II. Bromination, acylation and nitration of 4H‐ and 4‐benzoylfuro[3,2‐b]indoles
Authors: Tanaka Akira , Yakushijin Kenichi , Yoshina Shigetaka 
Published: April 2009

AbstractMonobromination and monoacylation at the 2‐position of 4H‐furo[3,2‐b]indole ring (III) were facilitated by the benzoyl group in the 4‐position; subsequent nitration attempts were unsuccessful.
Oxazolo analogs of the actinomycin D chromophore
Authors: Sengupta Sisir K. , Tinter S. Karin , Modest Edward J. 
Published: April 2009

AbstractCondensation of a tricyclic phenoxazin‐2‐amino‐3‐one (a model for the actinomycin D ring system) with acetaldehyde or benzaldehyde or with pyruvic acid as an acetaldehyde precursor gave tetracyclic 5H‐oxazolo[4,5‐b]phenoxazines. The pyruvic acid reaction proceeds efficiently in one step. The latter compounds were oxidized in a novel reaction by 2,3‐dichloro‐5,6‐dicyano‐benzoquinone exclusively at position 8 in the benzenoid ring. Uv, ir, nmr, and mass spectrometric data are reported.
Influence d'une fonction ester ou acide portée par la chaîne alcoxyle sur la réactivité des sels de N‐alcoxypyridinium envers les ions cyanures
Authors: Sliwa Henri , Tartar André 
Published: April 2009

AbstractL'étude de la réactivité, vis à vis des ions cyanures, de sels de N‐alcoxypyridinium portant une, fonction ester en ‐α dans leur chaine alcoxyle, montre que la formation de cyanopyridines est concurrencée par une décomposition en pyridine et ester α‐carbonylé, dont l'importance croît avec l'acidité de l'hydrogène‐α de cette chaîne alcoxyle. Une réactivité normale s'observe pour le sel 3 à carbone ‐α tertiaire, malgré l'encombrement stérique qu'il présente, et qui entraîne un accroissement de la proportion de cyano‐4 pyridine formée, au détriment de la cyano‐2 pyridine isomère. Les sels à fonction acide en ‐α ou en ‐β présentent une réactivité considérable‐ment plus faible, résultant d'une diminution du pH du milieu réactionnel et de la formation d'une bétaïne, moins réactive que l'ion pyridinium. L'existence de cette bétaïne sous une conformation repliée rendrait compte d'une réactivité relative plus grande du sommet −4 du cycle par rapport au sommet −2.
Alcoylation d'acridanone‐9. Premiers exemples de O‐alcoylation dans cette série de composés
Authors: Blanchard Christiane , Fabre Jean‐Marc , Montginoul Claude , Chaffia Brat Ali , Torreilles Eliane , Giral Louis 
Published: April 2009

AbstractLes résultats de différentes réactions de substitution de la méthoxy‐2 acridanone‐9 ont été interprétés sur la base d'une compétition entre les deux sites nucléophiles N et O de la molécule. Ils constituent les premiers exemples de O‐alcoylation d'acridanone‐9 substituéte.
Reduction studies on benzaza[3.3.3]propellanc derivatives
Authors: Campaigne E. , Mehra R. K. 
Published: April 2009

AbstractSodium borohydride reduction of 3‐methyl‐2,3‐dioxo‐7,8‐benzo‐3‐aza[3.3.3]propellan‐6‐one (1b) gave 2,4‐dioxo‐3‐methyl‐7,8‐benzo‐3‐aza[3.3.3]propellan‐6‐ol, while lithium aluminum hydride reduction gave 3‐methyl‐7,8‐benzo‐3‐aza[3.3.3]propellan‐6‐ol, which on oxidation, gave the corresponding ketone. This ketone formed the corresponding thioketal upon reaction with 1,2‐ethanedithiol. Raney nickel desulfurization of the thioketal provided 3‐methyl‐6,7‐benzo‐3‐aza[3.3.3]propellane. The same compound was also obtained in poor yield by forming the thioketal of Ib followed by lithium aluminum hydride reduction and Raney nickel desulfurization of the product. Desulfurization of the thioketal of Ib gave 2,4‐dioxo‐6,7‐Benzo‐3‐aza[3.3.3]propellane.
Structure moléculaire et propriétés moléculaires de quatre isomères de formule C8H10N4
Authors: Delettré Jean , Bally Renée , Mornon Jean‐Paul , Alcalde Ermitas , De Mendosa Javier , Faure Robert , Vincent Emile‐Jean , Elguero José 
Published: April 2009

AbstractLes structures moléculaires de trois isomères décrits par Meyer [méthyl‐3 (amino‐5′ rnéthyl‐3′ pyrazolyl‐1)‐3 acrylonitrile; azine de l'acétylacétonitrile; diméthyl‐2,5 amino‐7 pyrazolo[1,5‐a]pyrimidine] ont été déterminées et comparées à celle du quatrième isomère, dimèthyl‐2,7 amino‐5 pyrazolo[1,5‐a]pyrimidine. Des calculs CNDO/2 et CNDO/S ont été effectués utilisant comme base ces géométrìes pour déterminer les paramètres suivants: transitions électroniques, moments dipolaires, potentiels d'ionisation, charges et indices de liaison, énergies totales. On compare les valeurs calculées à une série de grandeurs expérimentales: spectres uv, déplacements chimiques 13C, constantes de couplage JHH et stabilité relative des quatre isomères.
Benzomorphan related compounds. V. Synthesis of thienomorphans
Authors: Alvarez M. , Bosch J. , Cranados R. , López F. 
Published: April 2009

AbstractA series of thieno [2,3‐ƒ]‐, [3,2‐ƒ]‐ and [3,4‐ƒ]morphans prepared both by the Grewe synthesis and by the reaction of 2‐cyanopyridines with 3‐thienyllithium is described. Furthermore, a new synthetic route to thieno [2,3‐ƒ] morphans from 3‐ketotetrahydrolhiophene is reported. Separation and assignment of the α‐ and β‐diastereomerie structures by means of nmr data is reported. Some side products were isolated and their structures were confirmed on the basis of their spectral data. Mechanisms for their formation are proposed.
Potential causal prophylactic antimalarial agents. Synthesis of quinoxaline, benzimidazole, and alkoxybenzene derivatives containing a novoldiamine moiety
Authors: Yan S. J. , Burton William H. , Chien Ping‐Lu , Cheng C. C. 
Published: April 2009

AbstractSeveral quinoxaline, benzimidazole, and alkoxybenzene derivatives containing the novoldiamine function, either as a side chain or incorporated as a ring constituent, were synthesized as potential causal prophylactic antimalarial agents. 1‐(5‐Dimethylamino‐2‐pentyl)‐5‐methoxy‐benzimidazole (2a) was shown to have the desired prophylactic activity in the preliminary sporozoitc‐indueedPlasmodium gallinaceumtest.
The synthesis of several para‐substituted tropanyl benzoates
Authors: Wallace J. L. , Kidd M. R. , Cauthen S. E. , Woodyard J. D. 
Published: April 2009

AbstractThe synthesis of the p‐methyl‐, p‐methoxy‐, p‐t‐butyl‐, p‐phenyl‐, p‐cyano‐, p‐bromo‐, p‐chloro‐and p‐nitrobenzoate esters of tropine are reported. These compounds were characterized by their hmr, ir, mass spectra and analytical data.
Synthesis of some 3‐acetyl‐5‐arylmethyl‐ or arylaminomethyltetronic acids from 4‐ethoxycarbonyl‐3‐(2H)furanone precursors
Authors: Chantegrel Bernard , Gelin Suzanne 
Published: April 2009

AbstractThe synthesis of a series of tetronic acids was accomplished by ring opening of new 4‐ethoxycarbonyl‐3(2H) furanones.
The pummerer rearrangement with 7‐(trifluoromethyl)dibenzo[b,e] [1,4]‐thiazepine‐5(11H)‐carboxaldehyde 10‐oxide. Formation of a novel 5,11‐bridged tetracycle
Authors: Yale Harry L. 
Published: April 2009

Abstract13‐Ethoxy‐7‐(trifluoromethyl)‐11H‐11,5‐(epoxymethano)dibenzo[b,e][1,4]thiazepine (3) was formed following the Pummerer Rearrangement of 7‐(trifluoromethyl)dibenzo[b,e] [1,4]‐thiazepine‐5(11H)carboxaldehyde 10‐oxide (1), when the work‐up involved the use of diethyl ether that contained ethanol as a normal ingredient, i.e., the grade of that solvent employed in anesthesia.
Synthèse d'hétérocycles dérivés du (+)‐camphre
Authors: Seube Serge , Lamazouère Anne‐Marie , Sotiropoulos Jean 
Published: April 2009

AbstractLes diamines agissent, suivant les conditions expérimentales, sur le dimercaptométhylène‐3 camphre avec formation, soit d'un bis‐oxothioamide, soit d'un hétérocycle par l'intérmediaire d'un oxoaminothioamide. De měme, les diamines réagissent sur les β‐oxothioamides pour conduire, par un mécanisme similaire où une transamination intervient, aux měmes hétérocycles dans lesquels le groupement carbonyle du camphre est conservé. Par contre, l'hydrazine avec les mémes dérivés du camphre donne des thioxo, alcoylamino ou arylamino indazoles. Cette hétérocyclisation se fait alors aux dépens du carbonyle du camphre.
Cyclization of 5‐amino‐1‐β‐d‐ribofuranosylimidazole‐4‐carboxamide (AICA‐riboside): A review
Authors: Yamazaki Akihiro , Okutsu Masaru 
Published: April 2009

AbstractThe synthesis of various purine nucleosides by cyclization of AICA‐riboside(5‐amino‐1‐β‐D‐ribofuranosylimidazole‐4‐carboxamide) is described. A variety of cyclization reactions provide new synthetic routes to inosine and guanosine. In this review, emphasis will be placed on the synthesis of the latter.
New, convenient synthesis of 2‐alkyl‐ and 2‐vinylpyrazolo[3,4‐d]‐pyrimidine derivatives
Authors: Senga Keitaro , Kanamori Yukako , Kanazawa Hashime , Nishigaki Sadao 
Published: April 2009

AbstractTreatment of 1,3‐dimethyl‐6‐hydrazinouracil with the appropriate dimethylformamide dialkylacetal afforded the, corresponding 2‐alkyl‐5,7‐dimethylpyrazolo[3,4‐d]pyrimidine‐4,6‐(5H,7H)diones. The reaction of 1,3‐dimethyl‐6‐(α‐methylbenzylidenehydrazino)uracils with dimethylformamide dimethylacetal or triethyl orthoformate gave the corresponding 5,7‐dimethyl‐2‐vinylpyrazolo[3,4‐d]pyrimidine‐4,6(5H,7H)diones, respectively. Similarly, treatment of 1,3‐dimethyl‐6‐(α‐methylbenzylidenehydrazino)uraeils with triethyl orthopropionate yielded the corresponding 5,7‐dimethyl‐3‐ethyl‐2‐vinylpyrazolo[3,4‐d]pyrimidine‐4,6(5H,7H)diones.
Selenium heterocycles XXV. Synthesis of thieno[3,4‐d][1,2,3]‐thiadiazole, selenolo[3,4‐d][1,2,3]thiadiazole and pyrrolo[3,4‐d][1,2,3]‐thiadiazole. Three novel ring systems
Authors: Shafiee Abbas 
Published: April 2009

AbstractStarting from the readily available 4‐bromomethyl‐5‐benzoyl‐1,2,3‐thiadiazole and 5‐bromomethyl‐4‐benzoyl‐1,2,3‐thiadiazole; thieno[3,4‐d][1,2,3]thiadiazole, selenolo[3,4‐d][1,2,3]‐thiadiazole and pyrrolo[3,4‐d][1,2,3]thiadiazole were synthesized in good yield.
Reaction of sulfamides with diketene (III). Synthesis of N‐sulfamoyl‐2,6‐dimethyl‐4‐pyrone‐3‐carboxamides
Authors: Goya P. , Stud M. 
Published: April 2009

AbstractPreparation of N‐(tetrahydropyran‐2‐yl)sulfamide, N‐(2,3,4,6‐tetra‐O‐aeetyl‐β‐D‐glucopyranosyl)sulfamide and N‐(2,3,5‐tri‐O‐benzoyl‐D‐ribosyl)sulfamide is described. Reactions with diketene, in the presence of pyridine, yielded N‐sulfamoyl‐2,6‐dimethyl‐4‐pyrone‐3‐carboxamide derivatives.
Ring transformations in reactions of heterocyclic compounds with nucleophiles (XX). Conversion of 5‐nitropyrimidine into 3,5‐dinitropyridine. A novel ring transformation
Authors: van der Plas H. C. , Jongejan H. , Koudijs A. 
Published: April 2009

AbstractHeating of 5‐nitropyrimidine with acetic acid in water leads to the formation of 3,5‐dinitro‐pyridine. The mechanism proposed for this novel ring transformation involves a fragmentation of the pyrimidine ring, leading to the formation of a two‐atom and a four‐atom moiety, which on condensation gives the pyridine ring. With hydrazine hydrate, 5‐nitropyrimidine undergoes ring contraction into 4‐nitropyrazole.
Quaternary derivatives from 2‐aminobenzimidazole and 2‐phenylethyl‐ and phenyloxymethyl halides
Authors: Yale Harry L. , Bristol J. A. 
Published: April 2009

Abstract2‐Aminobenzimidazole has been reacted with phenylethyl bromides and phenyloxymethyl chlorides to prepare a number of novel 1,3‐bis‐substituted quaternary derivatives.
Thermal rearrangement and fragmentation of 1a, 7b‐dihydro‐1H‐cyclopropa[c]cinnolines
Authors: Garanti Luisa , Zecchi Gaetano 
Published: April 2009

AbstractHeating of 1a, b in boiling xylene resulted in the rearranged products 2a, b, probably through concerted ring cleavage and 1,5‐hydrogen shift. Under the same conditions, 1c reacted slowly to give a mixture from which the fragmentation products 4 and 5 were obtained.
The synthesis of l‐alkyl‐1,4‐dihydro‐4‐quinolone‐2‐carboxylic acids
Authors: Cairns H. , Payne A. R. 
Published: April 2009

AbstractA general method tor the preparation of 1,4‐dihydro‐4‐quinolone‐2‐carboxylic acids, especially those which carry alkyl substituents on the ring N‐atom, is described.
Studies on furan derivatives. II. Preparation of α‐substituted β‐2‐(5‐nitrofuryl)vinylamines
Authors: Tanaka Akira , Usui Toshinao , Yoshina Shigetaka 
Published: April 2009

Abstractα‐Subslituted β‐2‐(5‐nitrofuryl)viriylamines were synthesized from α‐ary]‐β‐2‐(5‐nitrofuryl)‐aeryloyl azides and N‐[α‐substituled β‐2‐(5‐nitrofuryl)vinyl] pyridinium bromides.
An improved synthesis of gliamilide®, a high‐potency sulfamylurea hypoglycemic agent
Authors: Kuhla Donald E. , Sarges Reinhard , Barth Wayne E. 
Published: April 2009

AbstractAn efficient synthesis of the sulfamylurea, Gliamilide®, is described, which involves as a key feature the selective reduction of the more basic alkyl‐substituted pyridine ring in the mono‐hydrochloride salt of dipyridyl compound 11 to form 12 without affecting the 2‐methoxy‐nicotinamide moiety.
Synthesis of 7‐methoxy‐2‐methyl‐3,5,8‐isoquinolinetrione
Authors: Fukumi Hiroshi , Kurihara Hideshi , Mishima Hiroshi 
Published: April 2009

AbstractSynthesis of 7‐methoxy‐2‐methyl‐3,5,8‐isoquinolinetrione from either 7‐ or 8‐isoquinolinol is described. 3,5,8‐Isoquinolinetrione is a novel heteroeyelic quinune which constitutes the aromatic carbon skeleton of mimosamycin.
Quinazolines and 1,4‐benzodiazepines. LXXXV syntheses of 3‐substituted lmidazo[1,5‐a] [1,4]benzodiazepines
Authors: Walser Armin , Flynn Thomas , Fryer R. Ian 
Published: April 2009

Abstract1,4‐Benzodiazepines having a leaving group in the 2‐position were condensed with carbanions of 1,3‐dicarbonyl compounds. The products obtained were converted to the title compounds by a sequence of steps involving hydrolytic decarboxylation, nitrosation, catalytic hydrogenation and condensation with an orthoester or an amide acetal.Oxidative condensation of the enediamine 12 with a variety of aldehydes also led to imidazo‐benzodiazepines with various substituents in the 1‐position.
Assignment and solvent dependence of the carbon‐13 nuclear magnetic resonance spectrum of nicotine
Authors: Pitner T. Phil , Seeman Jeffrey I. , Whidby Jerry F. 
Published: April 2009

AbstractThe 13C nmr spectrum of nicotine is assigned in Acetone‐d6, DMSO‐d6, Pyridine‐d5, and deuterium oxide (pD 10.7, 5.4, < 1). Attention is focused on assignment of the closely‐spaced C(2) and C(6) resonances, using selective decoupling, population transfer, and long‐range coupling constant measurements. C(2) resonates at lower field in the organic solvents hut at higher field in deuterium oxide at all pD values investigated.
Selenium heterocycles XXVI. Synthesis of theino[3,4‐b]benzofuran and selenolo[3,4‐b] benzofuran. Two novel heterocycles
Authors: Shafiee A. , Behnam E. 
Published: April 2009

AbstractStarting from the readily available aryl 3‐methyl‐2‐benzo[b] furyl ketones a series of 3‐sub‐stituted thieno[3,4‐b] benzofurans and 3‐substituted selenolo[3,4‐b] benzofurans were prepared in high yield. The parent compound, thieno[3,4‐b] benzofuran was prepared through the reaction of thioacetamide with 2‐chloromethyl‐3‐formylbenzo[b] furan in moderate yield.
A novel synthesis of 8‐arylaminotheophyllines
Authors: Senga Keitaro , Ichiba Misuzu , Kanazawa Hashime , Nishigaki Sadao , Higuchi Masatsugu , Yoneda Fumio 
Published: April 2009

AbstractA novel synthesis of 8‐arylaminotheophyllines (8a‐e) by the reaction of 5‐arylazo‐6‐ethoxy‐methyleneamino‐1,3‐dimethyluracils (2a‐e) or 5‐arylazo‐1,3‐dimethyl‐6‐dimethylaminomethylene‐aminouracils (3a‐e) with sodium dithionite in formic acid is described.
Novel heterocycles. I. Synthesis and reactions of 6,7‐dihydro‐1H,3H,5H‐pyrido[3,2,l‐ij] [3,1]benzoxazine‐1,3‐dione
Authors: Coppola Gary M. 
Published: April 2009

Abstract6,7‐Dihydro‐1H,3H,5H‐pyrido[3,2,l‐ij][3,1 ]benzoxazine‐1,3‐dione (1b) was synthesized by a new route and its reactions with various nueleophiles are described.
An unexpected and efficient synthesis of 3‐chloro‐4‐cyanopyridine
Authors: Rokach Joshua , Girard Yves 
Published: April 2009

AbstractReaction of 4‐cyanopyridine N‐oxide with phosphorus oxychloride/phosphorus pentachloride gave 3‐chloro‐4‐cyanopyridine in good yield in sharp contrast to the expected chlorination in the 2‐position. A mechanistic interpretation of the results is proposed involving a chloride attack at the 4‐position as the main feature.
Authenticity of 2,6‐Dichloro‐1,5‐naphthyridine
Authors: Newkome George R. , Garbis Sam J. 
Published: April 2009

AbstractThe structure of 2,6‐dichloro‐1,5‐naphthyridine (1) was established based on physical and spectral data; thus, correcting the numerous inaccurate literature reports.
Substituted‐γ‐lactones. XXIX. N‐heterocycles via photolysis or thermolysis of 3‐(2‐azidophenylmethylene)‐4,5‐dihydro‐2‐(3H)furanone
Authors: Zimmer Hans , Downs Bruce 
Published: April 2009

AbstractThe thermolysis and/or photolysis of 3‐(2‐azidophenylmethylene)‐4,5‐dihydro‐2‐(3H)furanone offers a preparatively useful way towards the synthesis of indoles and quinolines. This method is superior over previously published methods which afforded these heterocycles in poor yields by the deoxygenative cyclization of 3‐(2‐nitrophenyImethylene)‐4,5‐dihydro‐2‐(3H)furanones. J. Heterocyclic Chem., 15, 703 (1978)