bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluation of Lightning Flash Rate Parameterizations in a Cloud‐Resolved WRF‐Chem Simulation of the 29–30 May 2012 Oklahoma Severe Supercell System Observed During DC3
Authors: Cummings K. A. , Pickering K. E. , Barth M. C. , Bela M. M. , Li Y. , Allen D. , Bruning E. , MacGorman D. R. , Ziegler C. L. , Biggerstaff M. I. , Fuchs B. , Davis T. , Carey L. , Mecikalski R. M. , Finney D. L. 
Published: June 2024

AbstractEighteen lightning flash rate parameterization schemes (FRPSs) were investigated in a Weather Research and Forecasting model coupled with chemistry cloud‐resolved simulation of the 29–30 May 2012 supercell storm system observed during the Deep Convective Clouds and Chemistry (DC3) field campaign. Most of the observed storm's meteorological conditions were well represented when the model simulation included both convective damping and lightning data assimilation techniques. Newly‐developed FRPSs based on DC3 radar observations and Lightning Mapping Array data are implemented in the model, along with previously developed schemes from the literature. The schemes are based on relationships between lightning and various kinematic, structural, and microphysical thunderstorm characteristics (e.g., cloud top height, hydrometeors, reflectivity, and vertical velocity) available in the model. The results suggest the model‐simulated graupel and snow/ice hydrometeors require scaling factors to more closely represent proxy observations. The model‐simulated lightning flash trends and total flashes generated by each scheme over the simulation period are compared with observations from the central Oklahoma Lightning Mapping Array. For this supercell system, 13 of the 18 schemes overpredicted flashes by >100% with the group of FRPSs based on storm kinematics and structure (particularly updraft volume) performing slightly better than the hydrometeor‐based schemes. During the storm's first 4 hr, the upward cloud ice flux FRPS, which is based on the combination of vertical velocity and hydrometeors, well represents the observed total flashes and flash rate trend; while, the updraft volume scheme well represents the observed flash rate peak and subsequent sharp decline in flash rate.
A Scale‐Dependent Analysis of the Barotropic Vorticity Budget in a Global Ocean Simulation
Authors: Khatri Hemant , Griffies Stephen M. , Storer Benjamin A. , Buzzicotti Michele , Aluie Hussein , Sonnewald Maike , Dussin Raphael , Shao Andrew 
Published: June 2024

AbstractThe climatological mean barotropic vorticity budget is analyzed to investigate the relative importance of surface wind stress, topography, planetary vorticity advection, and nonlinear advection in dynamical balances in a global ocean simulation. In addition to a pronounced regional variability in vorticity balances, the relative magnitudes of vorticity budget terms strongly depend on the length‐scale of interest. To carry out a length‐scale dependent vorticity analysis in different ocean basins, vorticity budget terms are spatially coarse‐grained. At length‐scales greater than 1,000 km, the dynamics closely follow the Topographic‐Sverdrup balance in which bottom pressure torque, surface wind stress curl and planetary vorticity advection terms are in balance. In contrast, when including all length‐scales resolved by the model, bottom pressure torque and nonlinear advection terms dominate the vorticity budget (Topographic‐Nonlinear balance), which suggests a prominent role of oceanic eddies, which are of km in size, and the associated bottom pressure anomalies in local vorticity balances at length‐scales smaller than 1,000 km. Overall, there is a transition from the Topographic‐Nonlinear regime at scales smaller than 1,000 km to the Topographic‐Sverdrup regime at length‐scales greater than 1,000 km. These dynamical balances hold across all ocean basins; however, interpretations of the dominant vorticity balances depend on the level of spatial filtering or the effective model resolution. On the other hand, the contribution of bottom and lateral friction terms in the barotropic vorticity budget remains small and is significant only near sea‐land boundaries, where bottom stress and horizontal viscous friction generally peak.
Evolution of Arc‐Continent Collision in the Southeastern Margin of the South China Sea: Insight From the Isugod Basin in Central‐Southern Palawan
Authors: Chen Wen‐Huang , Yan Yi , Carter Andrew , Clift Peter D. , Huang Chi‐Yue , Yumul Graciano P. , Dimalanta Carla B. , Gabo‐Ratio Jillian Aira S. , Zhang Le , Wang Ming‐Huei , Zhang Xin‐Chang 
Published: June 2024

AbstractThe evolution of arc‐continent collision between the Palawan microcontinental block and the Cagayan Ridge in the southeastern margin of the South China Sea (SCS) is vital to understand how this collision correlated with seafloor spreading of the SCS. To address the evolution of arc‐continent collision, we studied the biostratigraphy and provenance of syn‐collisional sediments in the Isugod Basin in central‐southern Palawan. Microfossil analysis indicates a Late Miocene age (11.5–5.6 Ma) for the Isugod and Alfonso XIII Formations and rapid subsidence during initiation of the basin which may have been triggered by local extensional collapse of the wedge in response to forearc uplift. Multidisciplinary provenance analysis reveals that the Isugod and Alfonso XIII Formations were derived from the Middle Eocene–lower Oligocene Panas‐Pandian Formation on the Palawan wedge and the Late Eocene Central Palawan Ophiolite. These results suggest the emergence of both the orogenic wedge and obducted forearc ophiolite at ∼11.5 Ma, implying collision onset before ∼11.5 Ma. The collision initiation in Palawan could be better constrained to ∼18 Ma, based on the drowning of the Nido carbonate platform in the foreland. Therefore, the gravitational collapse of the Palawan wedge and the subsidence/formation of the Isugod Basin might reflect a significant uplift pulse in the hinterland of the wedge beginning within 13.4–11.5 Ma in the late stage of collision. It indicates that although compression originated from spreading of the SCS had ceased at 16–15 Ma, arc‐continent collision in Palawan did not stop and was sustained by compression from the upper plate afterward.
South Asian Summer Monsoon Precipitation Is Sensitive to Southern Hemisphere Subtropical Radiation Changes
Authors: Hingmire Dipti , Hirasawa Haruki , Singh Hansi , Rasch Philip J. , Kim Sookyung , Hazarika Subhashis , Mitra Peetak , Ramea Kalai 
Published: June 2024

AbstractWe study the sensitivity of South Asian Summer Monsoon (SASM) precipitation to Southern Hemisphere (SH) subtropical Absorbed Solar Radiation (ASR) changes using Community Earth System Model 2 simulations. Reducing positive ASR biases over the SH subtropics impacts SASM, and is sensitive to the ocean basin where changes are imposed. Radiation changes over the SH subtropical Indian Ocean (IO) shifts rainfall over the equatorial IO northward causing 1–2 mm/day drying south of equator, changes over the SH subtropical Pacific increases precipitation over northern continental regions by 1–2 mm/day, and changes over the SH subtropical Atlantic have little effect on SASM precipitation. Radiation changes over the subtropical Pacific impacts the SASM through zonal circulation changes, while changes over the IO modify meridional circulation to bring about changes in precipitation over northern IO. Our findings suggest that reducing SH subtropical radiation biases in climate models may also reduce SASM precipitation biases.
Machine Learning Models for Evaluating Biological Reactivity Within Molecular Fingerprints of Dissolved Organic Matter Over Time
Authors: Zhao Chen , Wang Kai , Jiao Qianji , Xu Xinyue , Yi Yuanbi , Li Penghui , Merder Julian , He Ding 
Published: June 2024

AbstractReservoirs exert a profound influence on the cycling of dissolved organic matter (DOM) in inland waters by altering flow regimes. Biological incubations can help to disentangle the role that microbial processing plays in the DOM cycling within reservoirs. However, the complex DOM composition poses a great challenge to the analysis of such data. Here we tested if the interpretable machine learning (ML) methodologies can contribute to capturing the relationships between molecular reactivity and composition. We developed time‐specific ML models based on 7‐day and 30‐day incubations to simulate the biogeochemical processes in the Three Gorges Reservoir over shorter and longer water retention periods, respectively. Results showed that the extended water retention time likely allows the successive microbial degradation of molecules, with stochasticity exerting a non‐negligible effect on the molecular composition at the initial stage of the incubation. This study highlights the potential of ML in enhancing our interpretation of DOM dynamics over time.
Wavenumber‐4 Longitudinal Structure in ICON‐MIGHTI Thermospheric Meridional Wind
Authors: Meenakshi S. , Sridharan S. 
Published: June 2024

AbstractThe present study investigates wavenumber‐4 (wave‐4) structure in the longitude variation of zonal and meridional winds observed by the Michelson Interferometer for Global High‐resolution Thermospheric Imaging (MIGHTI) instrument onboard the Ionospheric Connection Explorer (ICON) satellite. The amplitude of the wave‐4 pattern in meridional wind displays semi‐annual variation with equinoctial maxima whereas its seasonal variation in zonal wind shows maxima during August–October at the equatorial and low latitudes. The wave‐4 longitude variation maximizes at lower thermospheric heights (below 130 km) in zonal and meridional winds. It is considered primarily driven by the non‐migrating eastward propagating diurnal tide with zonal wavenumber‐3 (DE3) in the zonal wind. However, the amplitude of DE3 tide in the meridional wind does not show any enhancement during September–October. The seasonal variations of the wave‐4 amplitude and the DE3 tide are not similar in the zonal and meridional winds. The migrating ter‐diurnal tide (TW3) exhibits significant amplitudes during March–April and September–November in the meridional wind. In addition, the latitude variation of non‐migrating TE1 tide shows maximum amplitude during September–October. These results suggest that the non‐linear interaction between the TW3 and TE1 tides can serve as a potential source for the wave‐4 longitude variation in the meridional wind at lower thermospheric altitudes.
Phthalate and phthalate replacement concentrations in relationship to adiposity in a multi-racial cohort of children
Authors: Hunt Kelly J. , Ferguson Pamela L. , Bloom Michael S. , Neelon Brian , Pearce John , Commodore Sarah , Newman Roger B. , Roberts James R. , Bain Lisa , Baldwin William , Grobman William A. , Sciscione Anthony C. , Tita Alan T. , Nageotte Michael P. , Palomares Kristy , Skupski Daniel W. , Zhang Cuilin , Wapner Ronald , Vena John E. 
Published: June 2024

Abstract
Background/Objective
Phthalates and phthalate replacements are used in multiple everyday products, making many of them bioavailable to children. Experimental studies suggest that phthalates and their replacements may be obesogenic, however, epidemiologic studies remain inconsistent. Therefore, our objective was to examine the association between phthalates, phthalate replacements and childhood adiposity/obesity markers in children.

Subjects/Methods
A cross-sectional study was conducted in 630 racial/ethnically diverse children ages 4–8 years. Urinary oxidative metabolites of DINCH and DEHTP, three low molecular weight (LMW) phthalates, and eleven high molecular weight (HMW) phthalates were measured. Weight, height, waist circumference and % body fat were measured. Composite molar sum groups (nmol/ml) were natural log-transformed. Linear regression models adjusted for urine specific gravity, sex, age, race-ethnicity, birthweight, breastfeeding, reported activity level, mother’s education and pre-pregnancy BMI.

Results
All children had LMW and HMW phthalate metabolites and 88% had DINCH levels above the limit of detection. One unit higher in the log of DINCH was associated with 0.106 units lower BMI z-score [β = −0.106 (95% CI: −0.181, −0.031)], 0.119 units lower waist circumference z-score [β = −0.119 (95% CI: −0.189, −0.050)], and 0.012 units lower percent body fat [β = −0.012 (95% CI: −0.019, −0.005)]. LMW and HMW group values were not associated with adiposity/obesity.

Conclusions
We report an inverse association between child urinary DINCH levels, a non-phthalate plasticizer that has replaced DEHP in several applications, and BMI z-score, waist circumference z-score and % body fat in children. Few prior studies of phthalates and their replacements in children have been conducted in diverse populations. Moreover, DINCH has not received a great deal of attention or regulation, but it is a common exposure. In summary, understanding the ubiquitous nature of these chemical exposures and ultimately their sources will contribute to our understanding of their relationship with obesity.
The relationship between the structural changes in the cervical spinal cord and sensorimotor function of children with thoracolumbar spinal cord injury (TLSCI)
Authors: Qi Qunya , Wang Ling , Yang Beining , Jia Yulong , Wang Yu , Xin Haotian , Zheng Weimin , Chen Xin , Chen Qian , Li Fang , Du Jubao , Lu Jie , Chen Nan 
Published: June 2024

Abstract
Study design
Cross-sectional study.

Objectives
To study the relationship between the structural changes in the cervical spinal cord (C2/3 level) and the sensorimotor function of children with traumatic thoracolumbar spinal cord injury (TLSCI) and to discover objective imaging biomarkers to evaluate its functional status.

Setting
Xuanwu Hospital, Capital Medical University, China; Beijing Key Laboratory of Magnetic Resonance Imaging and Brain Informatics, China.

Methods
30 children (age range 5–13 years) with TLSCI and 11 typically developing (TD) children (age range 6–12 years) were recruited in this study. Based on whether there is preserved motor function below the neurological level of injury (NLI), the children with TLSCI are divided into the AIS A/B group (motor complete) and the AIS C/D group (motor incomplete). A Siemens Verio 3.0 T MR scanner was used to acquire 3D high-resolution anatomic scans covering the head and upper cervical spinal cord. Morphologic parameters of the spinal cord at the C2/3 level, including cross-sectional area (CSA), anterior-posterior width (APW), and left-right width (LRW) were obtained using the spinal cord toolbox (SCT; https://www.nitrc.org/projects/sct). Correlation analyses were performed to compare the morphologic spinal cord parameters and clinical scores determined by the International Standard for Neurological Classification of Spinal Cord Injuries (ISNCSCI) examination.

Results
CSA and LRW in the AIS A/B group were significantly lower than those in the TD group and the AIS C/D group. LRW was the most sensitive imaging biomarker to differentiate the AIS A/B group from the AIS C/D group. Both CSA and APW were positively correlated with ISNCSCI sensory scores.

Conclusions
Quantitative measurement of the morphologic spinal cord parameters of the cervical spinal cord can be used as an objective imaging biomarker to evaluate the neurological function of children with TLSCI. Cervical spinal cord atrophy in children after TLSCI was correlated with clinical grading; CSA and APW can reflect sensory function. Meanwhile, LRW has the potential to be an objective imaging biomarker for evaluating motor function preservation.
Pharmacokinetic and neuroimmune pharmacogenetic impacts on slow-release morphine cancer pain control and adverse effects
Authors: Barratt Daniel T. , Klepstad Pål , Dale Ola , Kaasa Stein , Somogyi Andrew A. 
Published: June 2024

AbstractThe aim was to determine if opioid neuroimmunopharmacology pathway gene polymorphisms alter serum morphine, morphine-3-glucuronide and morphine-6-glucuronide concentration-response relationships in 506 cancer patients receiving controlled-release oral morphine. Morphine-3-glucuronide concentrations (standardised to 11 h post-dose) were higher in patients without pain control (median (interquartile range) 1.2 (0.7–2.3) versus 1.0 (0.5–1.9) μM, P = 0.006), whereas morphine concentrations were higher in patients with cognitive dysfunction (40 (20–81) versus 29 (14–60) nM, P = 0.02). TLR2 rs3804100 variant carriers had reduced odds (adjusted odds ratio (95% confidence interval) 0.42 (0.22–0.82), P = 0.01) of opioid adverse events. IL2 rs2069762 G/G (0.20 (0.06-0.52)), BDNF rs6265 A/A (0.15 (0.02–0.63)) and IL6R rs8192284 carrier (0.55 (0.34–0.90)) genotypes had decreased, and IL6 rs10499563 C/C increased (3.3 (1.2–9.3)), odds of sickness response (P ≤ 0.02). The study has limitations in heterogeneity in doses, sampling times and diagnoses but still suggests that pharmacokinetics and immune genetics co-contribute to morphine pain control and adverse effects in cancer patients.
Multivariate brain-behaviour associations in psychiatric disorders
Authors: Vieira S. , Bolton T. A. W. , Schöttner M. , Baecker L. , Marquand A. , Mechelli A. , Hagmann P. 
Published: June 2024

AbstractMapping brain-behaviour associations is paramount to understand and treat psychiatric disorders. Standard approaches involve investigating the association between one brain and one behavioural variable (univariate) or multiple variables against one brain/behaviour feature (‘single’ multivariate). Recently, large multimodal datasets have propelled a new wave of studies that leverage on ‘doubly’ multivariate approaches capable of parsing the multifaceted nature of both brain and behaviour simultaneously. Within this movement, canonical correlation analysis (CCA) and partial least squares (PLS) emerge as the most popular techniques. Both seek to capture shared information between brain and behaviour in the form of latent variables. We provide an overview of these methods, review the literature in psychiatric disorders, and discuss the main challenges from a predictive modelling perspective. We identified 39 studies across four diagnostic groups: attention deficit and hyperactive disorder (ADHD, k = 4, N = 569), autism spectrum disorders (ASD, k = 6, N = 1731), major depressive disorder (MDD, k = 5, N = 938), psychosis spectrum disorders (PSD, k = 13, N = 1150) and one transdiagnostic group (TD, k = 11, N = 5731). Most studies (67%) used CCA and focused on the association between either brain morphology, resting-state functional connectivity or fractional anisotropy against symptoms and/or cognition. There were three main findings. First, most diagnoses shared a link between clinical/cognitive symptoms and two brain measures, namely frontal morphology/brain activity and white matter association fibres (tracts between cortical areas in the same hemisphere). Second, typically less investigated behavioural variables in multivariate models such as physical health (e.g., BMI, drug use) and clinical history (e.g., childhood trauma) were identified as important features. Finally, most studies were at risk of bias due to low sample size/feature ratio and/or in-sample testing only. We highlight the importance of carefully mitigating these sources of bias with an exemplar application of CCA.
A novel doxorubicin/CTLA-4 blocker co-loaded drug delivery system improves efficacy and safety in antitumor therapy
Authors: Yang Wenli , Sun Qinghui , Zhang Xiaodian , Zheng Liping , Yang Xiaomei , He Na , Pang Yanyang , Wang Xi , Lai Zhiheng , Zheng Wuping , Zheng Shaoping , Wang Wu 
Published: June 2024

AbstractDoxorubicin’s antitumor effectiveness may be constrained with ineffective tumor penetration, systemic adverse effects, as well as drug resistance. The co-loading of immune checkpoint inhibitors and doxorubicin into liposomes can produce synergistic benefits and address problems, including quick drug clearance, toxicity, and low drug penetration efficiency. In our previous study, we modified a nanobody targeting CTLA-4 onto liposomes (LPS-Nb36) to be an extremely potent CTLA-4 signal blocker which improve the CD8+ T-cell activity against tumors under physiological conditions. In this study, we designed a drug delivery system (LPS-RGD-Nb36-DOX) based on LPS-Nb36 that realized the doxorubicin and anti-CTLA-4 Nb co-loaded and RGD modification, and was applied to antitumor therapy. We tested whether LPS-RGD-Nb36-DOX could targets the tumor by in vivo animal photography, and more importantly, promote cytotoxic T cells proliferation, pro-inflammatory cytokine production, and cytotoxicity. Our findings demonstrated that the combination of activated CD8+ T cells with doxorubicin/anti-CTLA-4 Nb co-loaded liposomes can effectively eradicate tumor cells both in vivo and in vitro. This combination therapy is anticipated to have synergistic antitumor effects. More importantly, it has the potential to reduce the dose of chemotherapeutic drugs and improve safety.
Fluoride and children’s IQ: evidence of causation lacking
Authors: Moore Deborah , Glenny Anne-Marie 
Published: June 2024

Abstract
Data sources
Human, animal, and in vitro studies. Extensive literature search of multiple bibliographic databases, trial registries, major grey literature sources and bibliographies of identified studies.

Study selection
The authors aimed to identify studies which could be used to determine the maximum safe level for fluoride in drinking water. To identify new studies published since a 2016 Australian review, the search period was 2016 to July 2021. Studies which evaluated the association between either naturally or artificially fluoridated water (any concentration) and any health outcomes were included. No restrictions on study design or publication status. Articles published in a ‘non-Latin language’ were excluded. Screening of abstracts and full texts was in duplicate. For IQ and dental fluorosis, a top-up search was conducted between 2021 and Feb 2023.

Data extraction and synthesis
Extensive data extraction. Risk of bias assessment using the OHAT tool. A narrative synthesis of the results was carried out.

Results
The review included 89 studies in humans, 199 in animals and 10 reviews of in vitro studies. Where there was consistent evidence of a positive association, in relation to a water fluoride concentration of <20 ppm (mg F/L), and where studies were judged to be acceptable or high quality, health effects were taken forwards for further examination of causality using Bradford Hill’s 9 criteria. Of the 39 health outcomes reviewed, 4 were further assessed for causality. The authors reported ‘strong’ evidence of causality for dental fluorosis and reductions in children’s IQ scores, ‘moderate’ strength evidence for thyroid dysfunction, ‘weak’ for kidney dysfunction, and ‘limited’ evidence for sex hormone disruption.

Conclusions
The authors conclude that moderate dental fluorosis and reductions in children’s IQ scores are the most appropriate health outcomes to use when setting an upper safe level of fluoride in drinking water. For reductions in children’s IQ, the authors acknowledge a biological mechanism of action has not been elucidated, and the dose response curve is not clear at lower concentrations, limiting the ability to set an upper safe threshold.