bluuebunny/crossref_metadata_2025_split huggingface dataset:
Integrated multi-omics and artificial intelligence to explore new neutrophils clusters and potential biomarkers in sepsis with experimental validation
Authors: Xu Peng , Tao Zuo , Zhang Cheng 
Published: May 2024

BackgroundSepsis, causing serious organ and tissue damage and even death, has not been fully elucidated. Therefore, understanding the key mechanisms underlying sepsis-associated immune responses would lead to more potential therapeutic strategies.MethodsSingle-cell RNA data of 4 sepsis patients and 2 healthy controls in the GSE167363 data set were studied. The pseudotemporal trajectory analyzed neutrophil clusters under sepsis. Using the hdWGCNA method, key gene modules of neutrophils were explored. Multiple machine learning methods were used to screen and validate hub genes for neutrophils. SCENIC was then used to explore transcription factors regulating hub genes. Finally, quantitative reverse transcription-polymerase chain reaction was to validate mRNA expression of hub genes in peripheral blood neutrophils of two mice sepsis models.ResultsWe discovered two novel neutrophil subtypes with a significant increase under sepsis. These two neutrophil subtypes were enriched in the late state during neutrophils differentiation. The hdWGCNA analysis of neutrophils unveiled that 3 distinct modules (Turquoise, brown, and blue modules) were closely correlated with two neutrophil subtypes. 8 machine learning methods revealed 8 hub genes with high accuracy and robustness (ALPL, ACTB, CD177, GAPDH, SLC25A37, S100A8, S100A9, and STXBP2). The SCENIC analysis revealed that APLP, CD177, GAPDH, S100A9, and STXBP2 were significant associated with various transcriptional factors. Finally, ALPL, CD177, S100A8, S100A9, and STXBP2 significantly up regulated in peripheral blood neutrophils of CLP and LPS-induced sepsis mice models.ConclusionsOur research discovered new clusters of neutrophils in sepsis. These five hub genes provide novel biomarkers targeting neutrophils for the treatment of sepsis.
The relationships between emerging adults self-efficacy and motivation levels and physical activity: a cross-sectional study based on the self-determination theory
Authors: Tao Yuexian , Xu Tao , Wang Xin , Liu Chengyi , Wu Yinyin , Liu Mingyue , Xiao Ting , Qiu Xinze 
Published: May 2024

ObjectivesThe study aims to examine the associations between exercise self-efficacy, motivation, physical activity, and body composition among emerging adults.DesignCross-sectional.MethodsA convenience sample of 147 emerging adults participated in the Releasing Weight (RELEW) project. The InBody720 analyzer was used to measure body composition, and the International Physical Activity Questionnaire-Short, the Shortened Physical Activity Self-Efficacy Scale, and the Treatment Self-Regulation Questionnaire were used to measure self-reported physical activity, self-efficacy, and motivation. Structural Equation Modeling was used to exam the complex relationships among multiple variables. in this study. The Partial least squares structural equation modeling analysis with bootstrapping in Smart PLS 3 was employed to explore the path coefficients and t-values for the relationships that were thought to exist. Significance was determined using a threshold of p &lt; 0.05.ResultsThe mean age of 147 participants was 18.5 ± 1.87, of whom 51.7% were female, recruited for this study. Exercise self-efficacy has a significant positive correlation with exercise motivation (r = 0.220, p = 0.008) and physical activity (r = 0.279, p &lt; 0.001). Exercise motivation does not demonstrate significant associations with physical activity (r = 0.094, p = 0.298). Utilizing SEM, the model explained 9.2% of exercise self-efficacy, 11.8% of physical activity, and 68.3% of body composition variance. Mediation analysis revealed that exercise self-efficacy partially mediated the relationship between exercise motivation and physical activity (β = 0.106, t = 2.538, p &lt; 0.05), and physical activity partially mediated the relationship between exercise self-efficacy and body composition (β = −0.296, t = 4.280, p &lt; 0.001).ConclusionThis study sheds light on the complex relationships among motivation, self-efficacy, physical activity and body composition during emerging adulthood. Our results highlight the mediating role of self-efficacy and its impact on physical activity behaviors, offering valuable insights for targeted interventions and policy development to improve health outcomes in this demographic.
Psychological intervention in women victims of childhood sexual abuse: a randomized controlled clinical trial comparing EMDR psychotherapy and trauma-focused cognitive behavioral therapy
Authors: Molero-Zafra Milagros , Fernández-García Olga , Mitjans-Lafont María Teresa , Pérez-Marín Marián , Hernández-Jiménez María Jesús 
Published: May 2024

IntroductionChildhood sexual abuse persists as a painful societal reality, necessitating responses from institutions and healthcare professionals to prevent and address its severe long-term consequences in victims. This study implements an intervention comprising two psychotherapeutic approaches recommended by the WHO and international clinical guidelines for addressing short-, medium-, and long-term posttraumatic symptomatology: Trauma-Focused Cognitive Behavioral Therapy (TF-CBT) and Eye Movement Desensitization and Reprocessing (EMDR). Both approaches are adapted from group formats for implementation in small online groups via Zoom.MethodsThe impact of both therapeutic approaches on trauma improvement was assessed in a sample of 19 women who were victims of childhood sexual abuse through a Randomized Clinical Trial comparing EMDR Psychotherapy and Trauma-Focused Cognitive Behavioral Therapy after a baseline period. Intra and inter comparison were made using statistics appropriate to the sample.ResultsBoth therapeutic approaches significantly reduced symptomatology across various evaluated variables, suggesting their efficacy in improving the quality of life for these individuals. Following CBT-FT treatment, patients exhibited enhanced emotional regulation, reduced reexperiencing, and avoidance. The EMDR group, utilizing the G-TEP group protocol, significantly improved dissociation, along with other crucial clinical variables and the perception of quality of life.DiscussionAlthough the limitations of this study must be taken into account due to the size of the sample and the lack of long-term follow-up, the results align with existing scientific literature, underscoring the benefits of trauma-focused psychological treatments. The online group format appears promising for enhancing the accessibility of psychological treatment for these women. Furthermore, the differential outcomes of each treatment support recent research advocating for the inclusion of both approaches for individuals with trauma-related symptomatology.Ethics and disseminationThe study has been approved by the Ethics Committee of the Valencian International University (VIU) (Valencia, Spain) (Ref. CEID2021_07). The results will be submitted for publication in peer-reviewed journals and disseminated to the scientific community.Clinical trial registrationhttps://clinicaltrials.gov/ct2/show/NCT04813224, identifier NCT04813224.
Intervention effects of telenursing based on M-O-A model in empty-nest older adult individuals with chronic diseases: a randomized controlled trial
Authors: Yuan Yuan , Hou Ping , Wang Sican , Kitayama Akio , Yanagihara Kiyoko , Liang Jingyan 
Published: May 2024

AimThis study aims to verify the effectiveness of M-O-A telenursing intervention model in improving the health status and quality of life of the empty-nest older adult individuals with chronic diseases by a randomized comparative trial.MethodsM-O-A telenursing intervention model was constructed based on the needs of the participants. The control group (N = 39) received routine nursing, the experimental group (N = 39) received M-O-A telenursing intervention in addition to routine nursing. After 12 weeks of intervention, the intervention effects of being a participant in the two groups were evaluated. SPSS 26.0 was used for data analysis.ResultsAfter 12 weeks of intervention, for the experimental group, each dimension of quality of life based on EQ-5D-3L became better, especially for “pain/discomfort,” “anxiety/depression,” “HRQoL” and “EQ-VAS” (all p &lt; 0.05) and each dimension of quality of life based on SF-36 became better too, especially for “GH,” “BP,” “RE,” “MH,” “VT,” “SF,” “PCS,” “MCS,” “SF-36” (all p &lt; 0.05). In addition, there was a statistical downward trend in blood pressure, blood glucose, weight, BMI, fat rate, nap duration, number of nocturnal awakenings, light sleep rate and a statistical upward trend in water rate, basal metabolic rate, nighttime sleep duration, deep sleep rate, rapid eye movement sleep rate, especially at the end of intervention (all p &lt; 0.05). While for the control group, there was no statistical improvement in all these aspects.ConclusionThe M-O-A telenursing model could effectively regulate quality of life and health condition of the empty-nest older adult individuals with chronic diseases, making it worthy of further promotion and application.
Location-dependent flight cost difference from the lunar surface to an orbital fuel depot and its influence on in situ resource utilisation location selection
Authors: Steinert Sven J. , Zabel Paul , Quantius Dominik 
Published: May 2024

Given the increasing relevance of lunar activities, the location selection for in situ resource utilisation (ISRU) facilities is necessary for identifying the most suitable configuration during mission planning. To gather information about the dominant location dependencies, a scenario is established wherein an ISRU product is exported to an orbital depot and its mass costs are used for classification. In the selected scenario, oxygen is produced in an ilmenite reduction plant and subsequently exported to the lunar gateway via an oxygen–hydrogen fuelled launcher operated in a round-trip to refuel oxygen at the lunar surface and hydrogen at the lunar gateway. This showed that the transport cost variations could be avoided entirely or have a recessive influence on the mission’s total costs over an extended period of time, such as 20 years. The identification of the top-10 most optimal locations for various resolutions was altered only slightly upon consideration of flight costs as compared to considering only the ISRU factors; this indicates the insignificance of flight cost dependencies for the analysed case.
The difference in radiographic findings in the distal limbs of working Lipizzan horses, used for dressage or driving
Authors: Zalig Valentina , Vengust Modest , Blagus Rok , Berner Dagmar , Sandow Cole , Hanna Ashley , Miklavcic Mitja 
Published: May 2024

IntroductionLameness originating from the distal limb is common in sport horses and can vary depending on the dynamics of movement and the surface, with differences in shoeing exacerbating this variability. Driving horses work primarily on hard surfaces (pavement), whereas dressage horses work primarily on soft surfaces (riding arenas with sand). Driving horses are traditionally shod with small fixed studs made of hard metal, which are attached to the horseshoe at 4 points, while dressage horses are shod with a simple horseshoe. We investigated the hypothesis that there is a difference in the pathological radiographic findings of the distal limbs between driving and dressage horses. The variability in the stable management and training program was minimized by including horses from the same farm.MethodsTwenty horses in a driving training program and 20 horses in a dressage program were included in the study. Radiographs of the both front feet were obtained and quantitatively evaluated for radiographic changes by three surgery/diagnostic imaging specialists. Interrater reliability was measured, and multivariate analysis was performed to compare differences in pathological radiographic findings of the distal limbs between the two groups.ResultsKendal’s concordance coefficient indicated an agreement among raters (Kw ≠ 0) for all observations. Radiographic signs of degenerative joint disease of the distal interphalangeal joint were more common in the group of driving horses compared to dressage horses.ConclusionOur hypothesis was confirmed, as there were significant pathological differences between groups in distal articular margin of middle phalanx, joint space narrowing, and irregular joint surface of the middle phalanx.
Ways of Development of Venereology in Russia (First Half of the XIX Century)
Authors: Заславский Д.В. , Белова Л.В. 
Published: May 2024

Цель. Проанализировать малоизученные вопросы путей развития венерологии в России (первая половина XIХ в.). Материалы и методы. Изучение научных трудов и докладов, изданий периодической печати, воспоминаний современников. Представлены редкие фотографии. Обсуждение. Восполнен пробел в историко-медицинской литературе. Дано целостное представление о развитии отечественной венерологии первой половины XIХ в. Показаны полемика ученых, их точки зрения, мнения, предложения, доводы. Проанализированы научные труды российских венерологов, определен их вклад в мировую науку. Организованная борьба с сифилисом в тот период не проводилась, предпринимались лишь попытки, а учет пациентов был несовершенным. Пытались организовать санитарное просвещение по венерическим болезням, в том числе на национальных языках. Представления правительства о способности легализации проституции и надзора врачебно-полицейских комитетов снизить заболеваемость сифилисом оказались иллюзорными. Заключение. Бесценный опыт российских ученых и врачей в изучении сифилиса и гонореи, преподавании является достоянием отечественной медицины, непреходящей ценностью для следующих поколений.
Purpose of the study. To analyse the little-studied issues of the ways of development of venereology in Russia (the first half of the XIХ century). Materials and methods. Study of scientific papers and reports, editions of periodicals, memoirs of contemporaries. Rare photographs are presented. Discussion. The gap in the historical-medical literature is filled. A holistic view of the development of Russian venereology in the first half of the XIХ century is given. The polemics of scientists, their points of view, opinions, proposals, arguments are shown. Scientific works of Russian venerologists are analysed, their contribution to the world science is defined. The organised fight against syphilis at that period was not carried out, only attempts were made, and the accounting of patients was imperfect. Attempts were made to organise health education on venereal diseases, including in national languages. The government’s belief that the legalisation of prostitution and the supervision of medical and police committees could reduce the incidence of syphilis proved to be illusory. Conclusion. The invaluable experience of Russian scientists and doctors in the study of syphilis and gonorrhoea, teaching is an asset of national medicine, an enduring value for the next generations.
Lichen Planus: Treatment Capabilities (Review)
Authors: Шикалов Р.Ю. , Панкратов О.В. , Панкратов А.О. , Левончук Е.А. , Крумкачев В.В. 
Published: May 2024

В статье приведен обзор методов лечения красного плоского лишая с поражением кожи, слизистых оболочек, волосистой части головы и ногтей, регламентируемых Национальными руководствами Республики Беларусь, Российской Федерации, а также рекомендуемых в литературе в качестве возможных или перспективных направлений. Представлена краткая характеристика предлагаемых лекарственных препаратов и информация о результатах их применения (глюкокортикоиды, ингибиторы кальциневрина, антималярийные, противогрибковые, ретиноиды, цитостатики, дапсон, сульфасалазин, микофенолата мофетил, антибиотики, средства для местного применения и физиотерапевтические методы). При всем разнообразии доступных терапевтических вариантов не существует общепризнанных международных руководств по лечению, основанных на данных крупных исследований. Новые данные изучения патогенеза КПЛ и применения генно-инженерных биологических препаратов, вероятно, смогут предоставить в ближайшей перспективе многообещающие возможности в лечении.
The article provides an overview of treatment methods of lichen planus with lesions of the skin, mucous membranes, scalp and nails, regulated by the National Guidelines of the Republic of Belarus, the Russian Federation, as well as recommended in the literature as possible or promising directions. A brief description of the proposed drugs and information on the results of their use are presented (glucocorticoids, calcineurin inhibitors, antimalarial, antifungal, retinoids, cytostatics, dapsone, sulfasalazine, mycophenolate mofetil, antibiotics, topical agents and physiotherapeutic methods). Despite the variety of therapeutic options available, there are no generally accepted international treatment guidelines based on data from large studies. New data on the pathogenesis of LP and the use of genetically engineered biological drugs will likely provide promising treatment opportunities in the near future.
PERBANDINGAN HASIL UBINAN PADI BERDASARKAN PEMBAGIAN WILAYAH DI KECAMATAN PANCA RIJANG KABUPATEN SIDENRENG RAPPANG TAHUN 2023
Authors: Salfiana Salfiana , Surianti Surianti , Khalik Abdul , Anas Fauziah , Inayah Astrina Nur , Nurwidah Andi , Hasanuddin Fenny 
Published: May 2024

Ubinan merupakan salah satu cara untuk memperoleh data produktivitas suatu tanaman. Data produktivitas ubinan biasanya digunakan untuk memberikan potensi hasil tanaman dari suatu luasan tertentu. Pada ilmu statistika, ubinan merupakan sampel/contoh. Pendekatan untuk memperoleh nilai produktivitas pertanian adalah dengan Survei Ubinan. Survei ubinan digunakan untuk memperkirakan produksi yang dihasilkan oleh lahan sawah 1 hektar. Survei ubinan ini mengambil sampel plot seluas 2,5 m x 2,5 m secara acak dengan metode statistik tertentu. Data produktivitas hasil ubinan banyak digunakan baik oleh peneliti/pengkaji atau Badan/Instansi yang bertugas mengumpulkan data produktivitas terutama tanaman padi. Di Kecamatan Panca Rijang Kabupaten Sidenreng Rappang telah dilakukan pengambilan 17 sampel ubinan padi di tiga desa yaitu Desa Bulo, Bulo Timoreng dan Timoreng Panua yang dilakukan dengan tujuan untuk mendapatkan informasi tentang produksi tanaman padi yang akurat. Berdasarkan data hasil pengambilan sampel ubinan padi di Kecamatan Panca Rijang menunjukkan berat ubinan tertinggi terdapat di Desa Bulo dengan berat ubinan 5.625 kg, sedangkan berat ubinan terendah terdapat pada Desa Bulo dengan berat ubinan 2.390 kg. Dari 17 sampel plot ubinan padi di Kecamatan Panca Rijang, dapat dilihat rata-rata produktivitas hasil ubinan yang dihasilkan yakni sebesar 4.827 kg. Berdasarkan hasil pengambilan sample ubinan padi di tiga desa tersebut dapat dilakukan kegiatan evaluasi bersama untuk perbaikan usahatani yang akan datang.
Peran Kepolisian Republik Indonesia dalam Pengawasan dan Penegakan Hukum terhadap Organisasi Kemasyarakatan
Authors: Sugianto Afif Muarmar; 
Published: May 2024

AbstractThe law on community organizations have changed several times. TheÂ government considered the change on the law on community organizations as very necessary and urgent, thus the government, in this case the President, was given the authority to issue a Government Regulation in lieu of law number 2 of 2017 which has been ratified by the House ofÂ Representatives with law number 16 of 2018. This study aimed to find out the implementation of the Policeâ€™s role in Supervision and Law Enforcement on Community Organizations, and to know the obstacles faced by the National Police in carrying out Supervision and Law Enforcement on Community Organizations. The method applied was an empirical juridical approach. The results of this study showed that the police have taken several efforts to provide guidance to the community such as providing counseling to the community, placing one Bhabinkamtibmas police officer in every village; and preventive efforts, namely the efforts of the police in order to maintain the security situation and public order.Key Words: Police; Supervision; and Law Enforcement.AbstrakUndang-Undang tentang organisasi kemasyarakatan mengalami beberapa kali perubahan yang memang dianggap pemerintah sangat perlu dan mendesak, sehingga pemerintah dalam hal ini Presiden berdasarkan kewenangannya diberikan oleh konstitusi dapat mengeluarkan PeraturanPemerintah Pengganti undang-undang nomor 2 tahun 2017 dan telah disahkan oleh Dewan Perwakilan Rakyat dengan Undang-undang nomor 16 tahun 2018. Penelitian ini bertujuan untuk mengetahui tentang implementasi peran Polisi dalam melakukan Pengawasan dan Penegakanhukum terhadap Oganisasi Kemasyarakatan, dan mengetahui hambatan-hambatan yang dihadapi Polri dalam melakukan Pengawasan dan Penegakan hukum terhadap Organisasi Kemasyarakatan. Metode yang digunakan adalah pendekatan secara yuridis empiris. Dan hasil dari penelitian bahwa upaya kepolisian dalam rangka melakukan pembinaan terhadap masyarakat melalui kegiatan pembinaan terhadap masyarakat, seperti memberikan penyuluhan terhadap masyarakat, penempatanBhabinkamtibmas di setiap desa satu orang anggota Polisi. Dan upaya preventif, yaitu upaya kepolisian dalam rangka menjaga situasi kemanan dan ketertibam masyarakat.Kata Kunci: Polisi; Pengawasan; dan Penegakan Hukum
ARTIFICIAL INTELLIGENCE (AI) AND INTERNET OF THINGS (IOT): THREATS OR FUTURE FOR THE POLICE?
Authors: Reza Alfin 
Published: May 2024

This study examined the impact of Artificial Intelligence (AI) and Internet of Things (IoT) technologies in policing from the perspective of challenges, threats, and readiness. This study adapted a systematic literature review with data obtained from journals and previous research articles in 2020 â€“ 2023. Previous studies concluded that crime is the shadow of civilization; therefore, the police must be able to keep up with the times. The development of an increasingly modern civilization causes more complex crime, AI and IoT will cause unimaginable crime potential. Countries all over the world have invested in the development of AI and IoT technologies for crime prevention and detection. The idea behind this investment is to make the crime predictable and detectable, allowing the police to enforce the law exactly and properly. Â AI systems are expected to overcome several human deficiencies, such as consistency in analyzing situations from multiple data sources, especially millions of data points from IoT devices.
PERAN KEPOLISIAN NEGARA REPUBLIK INDONESIA DALAM PENERAPAN SISTEM PERADILAN PIDANA
Authors: Sembiring Rudy 
Published: May 2024

Tugas pokok dan fungsi Polri, selain sebagai pengayom masyarakat juga sebagai penegak hukum. Moral utama dalam UU kepolisian, maka diperlukan pendekatan filosofis untuk memahami nilai-nilai tersebut. Tujuan dari artikel ini adalah untuk mengeksplorasi bagaimana penegakan hukum yang dilaksanakan oleh polri menunjukkan bahwa Nilai-nilai hukumÂ dalam pengaturan tugas dan fungsi Polri sebagai penegak hukum, adalah tugas yang utama , Kepolisian merupakan pintu masuk dalam penegakan hukum di Indonesia. Kepolisian sebagai gatekeepers (penjaga gerbang) sistem peradilan pidana memiliki peran sentral, karena sistem peradilan pidana dimulai dari Kepolisian. Di Indonesia banyak sekali terjadi pelanggaran hukum yang diproses sesuai hukum yang berlaku di Indonesia, namun ada juga pelanggarang yang belum bisa terselesaikan dengan alasan yang beragam. Artikel ini bertujuan untuk menelaah progres peranan kepolisian dalam sistem peradilan pidana di Indonesia.