bluuebunny/crossref_metadata_2025_split huggingface dataset:
Induction of High Endothelial Venule‐like Vessels Expressing GlcNAc6ST‐1‐mediated L‐selectin Ligand Carbohydrate and Mucosal Addressin Cell Adhesion Molecule 1 (MAdCAM‐1) in a Mouse Model of “Candidatus Helicobacter heilmannii”‐induced Gastritis and Gastric Mucosa‐associated Lymphoid Tissue (MALT) Lymphoma
Authors: Suzuki Akira , Kobayashi Motohiro , Matsuda Kazuyuki , Matsumoto Takeshi , Kawakubo Masatomo , Kumazawa Shigeyuki , Koide Naohiko , Miyagawa Shinichi , Ota Hiroyoshi 
Published: November 2010

AbstractBackground:  “Candidatus Helicobacter heilmannii” induce chronic gastritis, which eventually leads to gastric B‐cell type mucosa‐associated lymphoid tissue (MALT) lymphoma. This study was performed using an animal model of infection with “Candidatus Helicobacter heilmannii” to elucidate how this chronic inflammation is induced or maintained.Materials and Methods:  BALB/c mice were infected with the “Candidatus Helicobacter heilmannii” isolate SH4. The animals were examined at 8, 26, 54, and 83 weeks after the infection. The stomach of the animals was resected and immunostained for peripheral lymph node addressin (PNAd) and mucosal addressin cell adhesion molecule 1 (MAdCAM‐1), “Candidatus Helicobacter heilmannii,” and CD45R/B220. An in vitro binding assay with L‐ and E‐selectin·IgM chimeric proteins was performed. Real‐time polymerase chain reaction was used to evaluate transcripts of N‐acetylglucosamine‐6‐O‐sulfotransferases (GlcNAc6STs), which direct the expression of the PNAd and MAdCAM‐1.Results:  Chronic gastritis developed in the infected animals, and its severity increased with the duration of the infection. B‐cell type MALT lymphoma developed in some animals at 54 and 83 weeks after infection. PNAd‐ and MAdCAM‐1‐expressing high endothelial venule (HEV)‐like vessels were induced in infected animals which developed chronic gastritis and MALT lymphoma. The number of HEV‐like vessels increased as chronic inflammation progressed. The induced HEV‐like vessels were bound by L‐ and E‐selectin·IgM chimeric protein. mRNA expressions of GlcNAc6ST‐1 and MAdCAM‐1 increased in the infected animals.Conclusions:  HEV‐like vessels expressing GlcNAc6ST‐1‐mediated L‐selectin ligand carbohydrate and MAdCAM‐1 may play a crucial role in the pathogenesis of “Candidatus Helicobacter heilmannii”‐induced chronic gastritis and MALT lymphoma.
Identification of a Correlation between Helicobacter pylori Infection and Graves’ Disease
Authors: Bassi Vincenzo , Santinelli Crescenzo , Iengo Alba , Romano Carmela 
Published: November 2010

AbstractBackground:  viral and bacterial antigens have been suspected to be able to mimic the antigenic profile of the thyroid cell membrane and to play an important role in the onset of the autoimmune diseases, such as Graves’ disease and Hashimoto thyroiditis. The Helicobacter pylori infection is worldwide diffused and is present in the developed countries up to 50% of the population. The presence of the cytotoxin‐associated gene A antigens identifies the most virulent strains of the bacterium. Previous studies have demonstrated the possible correlation between the Helicobacter pylori and Hashimoto’s thyroiditis but these results are controversial.Aims:  We studied the prevalence rate of this bacterium in the Graves’ disease and two selected subgroups such as the hyperthyroid patients, at the first time of diagnosis, and the euthyroid methimazole‐treated patients.Materials and Methods:  We analyzed Helicobacter pylori in fresh stool samples with an enzyme immunoassay method and the presence of cytotoxin‐associated gene A antigens with a serological test.Results:  Our results show that a significative increased rate of prevalence is present in Graves' patients, when the disease is ongoing, with an overall prevalence of the strains expressing the cytotoxin‐associated gene A antigens compared to the control group.Conclusions:  The association between the Helicobacter pylori and Graves’ disease suggests a possible role of this bacterium in the onset and/or the maintenance of the disease.
Long‐Term Statin Therapy Affects the Severity of Chronic Gastritis
Authors: Nseir William , Khateeb Julnar , Tatour Imad , Haiek Samah , Samara Mousa , Assy Nimer 
Published: November 2010

AbstractBackground:  Helicobacter pylori (H. pylori) is a major cause of chronic gastritis. Statins have several pleotropic effects and their mechanisms of action could be related to anti‐inflammatory, antioxidants, and immunomodulatory effects.Aim:  To determine whether statin therapy affects the severity of chronic gastritis.Materials and Methods:  In a retrospective study, we evaluated 516 patients who underwent upper endoscopy. One‐hundred and ninety‐eight patients had chronic gastritis, The 198 patients with chronic gastritis were divided into two groups: group 1 comprised patients with a history of statin therapy and group 2 comprised patients with no history of statin therapy. Both groups were compared for age, gender, body mass index (BMI), underlying diseases, drug therapy, alcohol consumption, smoking and the serum levels of C‐reactive protein (CRP). The presence of H. pylori was determined by gastric biopsy and rapid urease test. The grade and severity of gastritis were assessed using the updated Sydney classification system in two gastric biopsy specimens that were taken from each participant in each group.Results:  Of the 198 patients with chronic gastritis, 49% of the patients had mild gastritis and 51% had moderate to severe gastritis. From the results of a multiple logistic regression analysis after adjusting for confounding variables that included age, gender, and BMI, we found that elevated serum CRP levels (odds ratio (OR) 2.33; 95% confidence interval (CI) = 0.8–2.6, p = .02), H. pylori (OR 1.99; CI 0.14–2.4, p = .04), and the use of statin (OR 1.64; CI = 0.71–1.77, p = .05) independently predict the severity of chronic gastritis.Conclusion:  Long‐standing statin therapy may reduce the severity of chronic gastritis. Mild increased CRP levels in absence of obvious source can predict the severity of chronic gastritis. Further researches are needed to assess the effect of statin in chronic gastritis.
Association Between Common Genetic Variants in Pre‐microRNAs and Gastric Cancer Risk in Japanese Population
Authors: Okubo Masaaki , Tahara Tomomitsu , Shibata Tomoyuki , Yamashita Hiromi , Nakamura Masakatsu , Yoshioka Daisuke , Yonemura Joh , Ishizuka Takamitsu , Arisawa Tomiyasu , Hirata Ichiro 
Published: November 2010

AbstractBackground:  Common single‐nucleotide polymorphisms (SNPs) in microRNAs (miRNA) have been shown to be associated with susceptibility to several human cancers. We evaluated the associations of three SNPs (rs11614913, rs2910164, and rs3746444) in pre‐miRNAs (miR‐196a2, miR‐146a, and miR‐499) with the risk of gastric cancer (GC) and peptic ulcer diseases, and with the severity of Helicobacter pylori‐induced gastritis in Japanese population.Methods:  The rs11614913 (C>T), rs2910164 (G>C), and rs3746444 (A>G) SNPs were genotyped in 552 GC, and 697 non‐cancer subjects, including 141 gastric and 73 duodenal ulcer, and 483 non‐ulcer subjects. The degree of histologic gastritis was classified according to the updated Sydney System, and the serum pepsinogen levels were measured in selected 579 and 204 cases.Results:  The rs2910164 CC genotype held a significantly higher risk of GC when compared to non‐cancer subjects (adjusted odds ratio (OR) = 1.30, 95% confidence interval (CI) = 1.02–1.66, p =.03). Similarly, the rs2910164 C carrier was associated with higher risk of GC when compared to both non‐cancer and non‐ulcer subjects (OR = 1.39, 95%CI = 1.00–1.93, p =.05, adjusted OR = 1.57, 95%CI = 1.09–2.27, p =.016, respectively). The rs2910164 CC genotype was associated with non‐cardia and upper third, diffuse type and advanced stage GC. The rs11614913 TT genotype was associated with higher degree of mononuclear cell infiltration (score 0–1 vs 2∼, adjusted OR = 1.62, 95%CI = 1.05–2.49, p =.03).Conclusions:  The rs2910164 (G>C) SNP in the miR‐146a is associated with susceptibility to GC. In addition, the rs11614913 (C>T) SNP in the miR‐196a2 is associated with the degree of H. pylori‐induced mononuclear cell infiltration.
Friere's Dialogic Concept Enables Family Health Program Teams to Incorporate Health Promotion
Authors: Heidemann Ivonete T. S. B. , Almeida Maria C. P. 
Published: November 2010

ABSTRACT
Objective: The study analyzes the possibility of incorporating health promotion measures into the work processes of Family Health Program teams at a primary health care clinic in Brazil.Design and Sample: We used the participatory research concept developed in 1968 by Freire. The study sample comprised the end‐users of the health care system, together with 3 multidisciplinary teams. A total of 77 health care users and 55 health professionals participated in the study.Measures: Culture circles composed of health care professionals, and users from different areas investigated generative topics, encoded/decoded topics, and engaged in critical probing for clarification. Topics affecting quality of life and health were heuristically evaluated.Results: Although most topics were related to changing the focus of health care facilities, some were related to subsidizing community‐based interventions, improving environmental strategies, individual skills, and public policies. Incorporating the novel health promotion measures and creating an expanded full‐treatment clinic are important steps toward that goal.Conclusions: Topics that can stimulate dialogue among the members of the culture circles include creating an environment of closer cultural contact, with repercussions for work processes, family health models, and general health models, as well as the inclusion of social aspects in the decision‐making processes related to health issues that affect the living conditions of the population.
Use of the Cumulative Summation Technique to Quantitatively Assess a Surgical Learning Curve: Canine Total Hip Replacement
Authors: Hayes Graham M. , Ramirez Juan , Langley Hobbs Sorrel J. 
Published: November 2010

Objective:To quantitatively assess a surgical “learning curve” using the cumulative summation (CUSUM) score technique.Study Design:Application of a CUSUM technique to a consecutive series of surgical cases.Animals:Consecutive primary cemented total hip replacement (THR; n=116) in 106 dogs.Methods:Records of all dogs that had primary canine THR were reviewed. Data retrieved included date of surgery, postoperative complications, and duration of follow‐up. The 12‐week outcome was analyzed graphically and with a CUSUM technique.Results:One hundred and one (87%) procedures were “successful” and 15 (13%) developed major complications within 12 weeks (failures). The CUSUM chart clearly demonstrated an initial “learning curve” of ∼44 THR.Conclusion:The CUSUM technique can be used to demonstrate the learning curve for canine THR surgery.
Canine Sacroiliac Luxation: Anatomic Study of the Craniocaudal Articular Surface Angulation of the Sacrum to Define a Safe Corridor in the Dorsal Plane for Placement of Screws used for Fixation in Lag Fashion
Authors: Bowlt Kelly L. , Shales Christopher J. 
Published: November 2010

Objective:To define a safe corridor in the dorsal plane relative to the articular surface for placement of a single screw in lag fashion to achieve stabilization of sacroiliac luxation in the dog.Study Design:Cadaveric study.Methods:Dorsoventral radiographs of denuded canine sacra (n=49) were taken to determine the safe corridor in the craniocaudal plane, and the maximum, optimum and minimum angles were calculated that would allow a screw inserted in lag fashion to engage at least 60% of the width of the sacral body without cranial or caudal penetration through the bone.Results:The mean safe corridor in the dorsal plane is ∼24° wide. Mean craniocaudal minimum, optimum and maximum drill angles from the drill start point were 88°, 100°, and 111° from the articular surface, respectively. No single angle will completely avoid risk of screw penetration beyond the safe corridor cranially and caudally.Conclusions:There is sufficient anatomic variation between different canine sacra that a single angle cannot be recommended for screw placement in the dorsal plane.Clinical Relevance:A standard angle cannot be recommended for screw placement in lag fashion within the canine sacrum in the dorsal plane. Because of the narrow width of the safe corridor, preoperative measurements on radiographs are recommended and a range of angled drill guides may be useful to decrease surgeon margin of error.
Fanconi syndrome in a patient with β‐thalassemia major after using deferasirox for 27 months
Authors: Wei Hsin‐Yi , Yang Chao‐Ping , Cheng Chi‐Hui , Lo Fu‐Sung 
Published: November 2010

BACKGROUND: Deferasirox (DFRA) is a new approved oral iron chelator. Its advantages are that it is convenient and better tolerated and adhered to due to “once‐daily” oral dosage. However, its use in the field is limited and it is yet to be subjected to postmarketing surveillance.CASE REPORT: A 18.75‐year‐old male with β‐thalassemia major received oral DFRA therapy due to transfusional iron overload for 27 months. He had received iron chelation therapy with deferoxamine injection together with oral deferiprone. However, his compliance was poor (very high routine serum ferritin level, ranging from 1059 to 6030 ng/mL). After 25 months of DFRA therapy, the serum ferritin level declined from 4097 to 1343 ng/mL. He experienced five hospital admissions including coma, Fanconi syndrome, hepatic dysfunction, and thrombocytopenia after using DFRA as oral iron chelator. After we discontinued DFRA, he recovered fully without hepatic dysfunction, thrombocytopenia, proteinuria, glucosuria, and hypophosphatemia.CONCLUSIONS: Our case illustrates the potential risks of DFRA‐induced renal toxicity, hepatic dysfunction, and thrombocytopenia. Meticulous monitoring of kidney, liver, and hematopoietic function is mandatory for patients undergoing treatment with DFRA. Further investigation of the potential risk and adverse effects of long‐term DFRA use is necessary.
Use of Cryoablation for Treatment of Tachyarrhythmias in 2010: Survey of Current Practices of Pediatric Electrophysiologists
Authors: COLLINS KATHRYN K. , SCHAFFER MICHAEL S. 
Published: November 2010

Background:
Cryoablation for arrhythmia substrates in pediatrics has been available since 2003. The purpose of this study was to evaluate the current approach of pediatric electrophysiologists to the use of cryoablation in the current era.
Methods:
We sent an Internet link to an online survey to all members of the Pediatric and Congenital Electrophysiology Society. Individuals and not institutions were surveyed.
Results:
A total of 70 responses were received. Responding physicians were largely invasive pediatric electrophysiologists (94%) who practice at mid‐ to high‐volume centers (>50 ablation procedures/year). Survey responders report that cryoablation was utilized for <50% of the ablation volume, and most utilize it for only 10%. With respect to specific arrhythmia substrates, 41% of responders use cryoablation as first‐line therapy for atrioventricular nodal reentrant tachycardia. For accessory pathways, 94% report that cryoablation would only be utilized after mapping the accessory pathway to a “high‐risk location.” Other arrhythmia substrates considered for cryoablation would be accessory pathways mapped to high‐risk areas, junctional ectopic tachycardia, a parahisian ectopic atrial tachycardia, or an atrial tachycardia near the phrenic nerve.
Conclusion:
For pediatric electrophysiologists who responded to the survey, radiofrequency energy remains the primary energy source for ablation. The current use of cryoablation technology is directed at arrhythmia substrates near the normal conduction system or other “high‐risk” areas. (PACE 2011; 34:304–308)
Role of HLA‐G and NCR in protection of umbilical cord blood haematopoietic stem cells from NK cell mediated cytotoxicity
Authors: Wang Ming , Qiu Yuhua , Wang Xuelei , Zhao Fang , Jin Min , Xu Ming , Rong Ruiming , Ge Hailiang , Zhang Yanyun , Wang Xiangdong , Zhu Tongyu 
Published: November 2010

AbstractAllogeneic umbilical cord blood haematopoietic stem cells (UCB–HSCs) can be transplanted into a host with the intact innate immunity with limited immuno‐reaction, although the mechanisms remain unclear. The present studies aimed at investigating potential mechanisms of allogeneic UCB–HSCs escape from the cytolysis of natural killer (NK) cells. We compared UCB–HSCs ability to protect from NK‐mediated cytotoxicity with peripheral blood or bone marrow haematopoietic stem cells (PB‐HSCs and BM‐HSCs). HSCs expressed lower levels of natural cytotoxicity receptor ligands including NKp30L, NKp44L and NKp46L than monocytes. Blocking these ligands respectively or in combination could increase the resistance of HSCs against NK cell mediated cytotoxicity. High expression of HLA‐G was noticed on UCB–HSCs, rather than PB‐HSCs or BM‐HSCs, whereas blockade of HLA‐G significantly elevated NK cell mediated cytolysis to UCB–HSCs. Thus, we conclude that natural cytotoxicity receptors and HLA‐G on HSCs may contribute to the escape from NK cells, and activate and inhibitory NK cell receptors and their ligands can be novel therapeutic targets in cell transplantation.
Selecting fish‐based metrics responding to human pressures in French natural lakes and reservoirs: towards the development of a fish‐based index (FBI) for French lakes
Authors: Launois L. , Veslot J. , Irz P. , Argillier C. 
Published: November 2010

Launois L, Veslot J, Irz P, Argillier C. Selecting fish‐based metrics responding to human pressures in French natural lakes and reservoirs: towards the development of a fish‐based index (FBI) for French lakes. Ecology of Freshwater Fish 2011: 20: 120–132. © 2010 John Wiley & Sons A/SAbstract –  Fish‐based indices of biotic integrity have been developed for many lotic systems but remain scarce for lakes. The goal of this study was to assess the responses of lentic fish assemblages to anthropogenic pressures when environmental variability was controlled for and to compare them between French natural lakes and reservoirs. Environmental features, catchment‐scale anthropogenic descriptors and fish data were collected from 30 natural lakes and 59 reservoirs throughout France. Functional fish metrics were regressed against both anthropogenic variables and the natural environmental conditions. Our results show that fish assemblages are appropriate ecological indicators for both natural and artificial lakes. They underline the necessity to control for the environment when developing indices at broad geographical scales. The relevant metrics differ between natural lakes and reservoirs, which challenges the attempts to use natural systems as references to assess the ecological potential of artificial ones.
Exploring Relationships Among Maternal BMI, Family Factors, and Concern for Child's Weight
Authors: Payas Nydjie , Budd Geraldine M. , Polansky Marcia 
Published: November 2010

PROBLEM:  In an effort to better understand child obesity, this study examined the association between family living location, family function, mother's body mass index (BMI), and mothers' attitudes and behaviors concerning child feeding. Recent research on obesity has shown there is limited information on family influence and parental perceptions and attitudes.METHODS:  A cross‐sectional analysis was performed on data from 47 mothers of school‐aged children.FINDINGS:  Urban African‐American mothers had higher BMIs and were significantly more concerned about their child's weight status than rural white mothers. Additionally, maternal BMI was associated with the total number of individuals in the household.CONCLUSION:  Results suggest the importance in understanding the family and community and its influence on childhood obesity. Armed with knowledge about family factors and parents' beliefs and perceptions, nurses can develop interventions that can assist families and communities to focus on healthy children feeding and weight management.
Developmental Health of Infants and Children Subsequent to Foster Care
Authors: Bruskas Delilah 
Published: November 2010

BACKGROUND: Every day, the United States child welfare system is entrusted with the care of over 400,000 children through foster care. The majority of children entering this social setting are infants, the most developmentally vulnerable.METHODS: Bronfenbrenner'shuman health ecology model andBowlby'sattachment theory are used to delineate the social setting of foster care and its impact on developmental health, and elucidates the relationship between childhood experiences and the overall continuum of health. Additionally, the notion of inherited genes and environmental influences or epigenetics toward gene expression will be explored.RESULTS: Research points out that what happens in childhood matters; the consequences of not addressing childhood adversity and the associated risk factors of foster care increase a child's risk for poor developmental health and other major illnesses noted later in life such as cardiac disease, depression, and even premature death. Healthcare providers and others charged with caring for this vulnerable population who understand the social setting of foster care and its impact on developmental health may help identify and treat developmental problems earlier, thus potentially reducing long‐term effects of abuse and neglect.CONCLUSION: Improvement plans that promote best practice for child welfare must include those that directly address the unique developmental needs of all infants and children in foster care itself. Such plans will ensure that foster care as an intervention to protect vulnerable children at risk does not create more harm by reducing the associated risks and maximizing benefits while in foster care, and ensures that those born genetically vulnerable and disproportionately susceptible to poor outcomes in adversity are also protected and provided opportunities that promote optimal developmental health.
Physicochemical and microbiological quality of water from a pilot domestic rainwater harvesting facility in Ireland
Authors: O'Hogain S. , McCarton L. , McIntyre N. , Pender J. , Reid A. 
Published: November 2010

AbstractDublin Institute of Technology personnel were commissioned in 2005 by the Department of Environment, Heritage and Local Government in Ireland to assess the feasibility of utilizing harvested rainwater to replace treated mains water, for nonpotable uses. A pilot project was set up. The project involved the design, installation, commissioning and monitoring of rainwater harvesting facilities in a rural housing development. A monitoring programme was carried out to examine the physicochemical and microbiological quality of the harvested rainwater. Harvested rainwater was sampled monthly and tested. Analysis of the harvested rainwater quality showed a consistently high quality of raw water in general compliance with the requirements of the European Communities (Quality of Bathing Water) Regulations for 100% of samples and the European Communities (Drinking Water) Regulations, 2007 for 37% of sampling dates.