bluuebunny/crossref_metadata_2025_split huggingface dataset:
Correlation between coping style and quality of life among hemodialysis patients from a low‐income area in Brazil
Authors: SANTOS Paulo Roberto 
Published: May 2010

AbstractQuality of life (QOL) is an important outcome among end‐stage renal disease patients and can be associated with modifiable behaviors. We analyzed the correlation between coping style and QOL among hemodialysis patients. We studied 166 end‐stage renal disease patients undergoing hemodialysis. They were older than 18 years, under hemodialysis for at least 3 months, and had never received a transplant. Quality of life was assessed by SF‐36 and coping style was scored by the Jalowiec Coping Scale. Emotion‐oriented coping and problem‐oriented coping scores were compared according to sex, comorbidity, and socioeconomic status by the Mann‐Whitney test. Correlations between QOL and 2 coping styles (emotion‐oriented coping and problem‐oriented coping) were adjusted for age, time on dialysis, hemoglobin, creatinine, albumin, calcium–phosphorus product, and Kt/V by backward stepwise linear regression. There was no difference between coping scores according to sex, comorbidity, and socioeconomic status. Emotion‐oriented coping was independently and negatively associated with 4 QOL dimensions: physical functioning, role‐physical, role‐emotional, and mental health. Our results indicate that patients with high emotion‐oriented coping scores should be seen at risk for poor QOL. Patient education in coping skills may be used to change the risk of poor QOL.
Influence of dietary yeasts onDrosophila melanogasterlife‐history traits
Authors: Anagnostou Christiana , Dorsch Monika , Rohlfs Marko 
Published: May 2010

AbstractAn organism’s fitness is highly dependent on resource quality. The diet of saprobiotic organisms often comprises a variety of microorganisms. SaprophagousDrosophila melanogasterMeigen (Diptera: Drosophilidae) is known to feed on various yeast species, both as larva and adult. The yeasts encountered by the insects may differ in composition and quality, and thus in their influence on larval and adult performance. Our study explores life‐history consequences of larval diet on selected larval and adult traits, as well as larval and adult food choice and egg‐laying behaviour. The chosen yeast species could be shown to influence several life‐history traits ofD. melanogaster, such as survival, development time, and adult body weight. Additionally, the amount of yeast biomass initially fed to the larvae significantly influenced development time and adult body weight, whereby the effect depended on the yeast species offered. There were also yeast‐specific influences on the measured fitness traits when larvae were reared at different densities. Larvae exhibited a preference for those yeast species that had shown to favour most of the measured life‐history traits. Adults, on the other hand, exhibited a different preference. Contrary to our expectation based on the preference‐performance hypothesis, female adult flies did not prefer to lay their eggs on substrates inoculated with yeast species that had been shown to favourably influence larval development time. Possible reasons for this seemingly ‘bad mother’‐behaviour are being discussed.
Risk factors for obesity in childhood survivors of suprasellar brain tumours: a retrospective study
Authors: Lek Ngee , Prentice Philippa , Williams Rachel M , Ong Ken K , Burke Gladstone Austin Amos , Acerini Carlo L 
Published: May 2010

AbstractAim:  To characterize postdiagnosis changes in body mass index (BMI) among childhood survivors of suprasellar brain tumours, and to determine the risk factors associated with obesity.Methods:  We conducted a retrospective analysis of 46 children (16 boys and 30 girls) with median (IQR) age of 7.49 (3.47–11.59) years at tumour diagnosis, and followed up for 3.93 (1.68–7.27) years. Survival analyses were used to identify risks of developing obesity.Results:  There were no sex differences in age at tumour diagnosis, duration of follow‐up, tumour types, endocrinopathies, treatment modalities or baseline BMI SDS. In the first year after tumour diagnosis, ΔBMI SDS (median; IQR) was greater in girls (1.32; 0.07–2.08) than in boys (0.48; −0.40 to 0.89) (p = 0.01). At diagnosis, 3/46 children (6%) were obese; this increased to 20/46 (43%) by last follow‐up (p < 0.001) and was more common in girls (17/30; 57%) than in boys (3/16; 19%). Female gender (hazard ratio 5.0, 95% CI 1.2–21.7; p = 0.04) and greater than average baseline BMI (hazard ratio 4.7, 95% CI 1.1–20.8; p = 0.02) were risk factors for subsequent obesity.Conclusion:  Accurate prediction of obesity risk is important and would allow early targeted intervention in high‐risk patients.
Post‐translational modification of the deubiquitinating enzyme otubain 1 modulates active RhoA levels and susceptibility to Yersinia invasion
Authors: Edelmann Mariola J. , Kramer Holger B. , Altun Mikael , Kessler Benedikt M. 
Published: May 2010

Microbial pathogens exploit the ubiquitin system to facilitate infection and manipulate the immune responses of the host. In this study, susceptibility to Yersinia enterocolitica and Yersinia pseudotuberculosis invasion was found to be increased upon overexpression of the deubiquitinating enzyme otubain 1 (OTUB1), a member of the ovarian tumour domain‐containing protein family. Conversely, OTUB1 knockdown interfered with Yersinia invasion in HEK293T cells as well as in primary monocytes. This effect was attributed to a modulation of bacterial uptake. We demonstrate that the Yersinia‐encoded virulence factor YpkA (YopO) kinase interacts with a post‐translationally modified form of OTUB1 that contains multiple phosphorylation sites. OTUB1, YpkA and the small GTPase ras homologue gene family member A (RhoA) were found to be part of the same protein complex, suggesting that RhoA levels are modulated by OTUB1. Our results show that OTUB1 is able to stabilize active RhoA prior to invasion, which is concomitant with an increase in bacterial uptake. This effect is modulated by post‐translational modifications of OTUB1, suggesting a new entry point for manipulating Yersinia interactions with the host.Structured digital abstract
MINT‐7717124: ypkA (uniprotkb:Q05608) physically interacts (MI:0915) with OTUB1 (uniprotkb:Q96FW1) by anti bait coimmunoprecipitation (MI:0006)
MINT‐7717229: rhoA (uniprotkb:P61586) physically interacts (MI:0915) with OTUB1 (uniprotkb:Q96FW1) by affinity chromatography technology (MI:0004)
MINT‐7717075, MINT‐7717207, MINT‐7717193, MINT‐7717170: ypkA (uniprotkb:Q56921)  physically interacts (MI:0915) with OTUB1 (uniprotkb:Q96FW1) by anti tag coimmunoprecipitation (MI:0007)
MINT‐7717390: ypkA (uniprotkb:Q56921) physically interacts (MI:0914) with OTUB1 (uniprotkb:Q96FW1) and RhoA (uniprotkb:P61586) by anti tag coimmunoprecipitation (MI:0007)
Older people maintaining mental health well‐being through resilience: an appreciative inquiry study in four countries
Authors: Moyle Wendy , Clarke Charlotte , Gracia Natalie , Reed Jan , Cook Glenda , Klein Barbara , Marais Sandra , Richardson Elsie 
Published: May 2010

moyle w, clarke c, gracia n, reed j, cook g, klein b, marais s & richardson e (2010) Journal of Nursing and Healthcare of Chronic Illness 2, 113–121 Older people maintaining mental health well‐being through resilience: an appreciative inquiry study in four countriesAim.  To explore the experience and strategies of mental health well‐being through resilience in older people across the four participating countries.Background.  While there is increasing evidence of the way older people maintain physical well‐being, there has not been the same emphasis when examining the ways in which older people enhance their resilience and so promote mental health well‐being.Design.  An Appreciative Inquiry approach was used.Method.  A convenience sample of 58 people over the age of 65 years from Australia, UK, Germany, and South Africa were interviewed. Data were analysed using thematic analysis.Results.  Participants described their experiences of mental health well‐being in relation to: social isolation and loneliness; social worth; self‐determination; and security. Strategies utilised include promoting resilience by maintaining community connections and relationships, keeping active, and emotional, practical and spiritual coping.Conclusion.  The findings highlight the importance of maintaining mental health well‐being through resilience. Although there were some variations between countries, these strategies for maintaining well‐being transcended culture and nation.Relevance to clinical practice.  Listening to older people through research such as the current study will help to determine what help is needed and how healthcare and policy makers can assist.
Implementation of a diabetes nurse case management program in a primary care clinic: a process evaluation
Authors: Wolber Teresa , Ward Deborah 
Published: May 2010

wolber t & ward d (2010)
Journal of Nursing and Healthcare of Chronic Illness 2, 122–134 Implementation of a diabetes nurse case management program in a primary care clinic: a process evaluationAims and objectives.  The aim was to evaluate the design and implementation of a diabetes nurse case management program in a busy primary care practice. The process outcomes include: (1) demonstration of nurse competence in motivational interviewing techniques, collaborative use of medication protocols, and identification of achievable self‐management goals; (2) achieving a caseload of 15 to 20 patients; (3) evidence of weekly patient contacts; (4) demonstration of collaboration with primary care providers; (5) sustainability of the program through staff changes.Background.  Program success or failure is determined not only by sound assumptions regarding how the interventions work but also by the strategy of implementation used and whether it was implemented properly. The utilisation of nurse case managers skilled in motivational interviewing techniques, independent use of medication protocols, and application of patient self‐management goals have improved patient diabetic outcomes in multiple settings. There is little literature on how to translate this evidence into busy primary care settings.Method.  Four generalist nurses, trained in motivational interviewing, medication protocols and diabetes self‐management contacted patients by phone at one to two week intervals over a six‐month period. Quantitative evaluation was done through chart review and taped nurse encounters. Qualitative information was obtained using structured nurse interviews and participant observations at monthly nurse/provider meetings.Conclusions.  Key attributes necessary for successful implementation include embracing principles of redesign at all levels, access to a central data base and electronic medical records for time efficiency, constant redistribution of tasks among team members, continuous constructive feedback to reach nurse competency, and a frank discussion of nursing scope of practice and autonomy.Relevance to clinical practice.  This study identifies a promising model to implement nurse case management in primary care. Early outcome results favour dissemination across the organization. Adaptation of this program to other settings is possible using process evaluation planning.
Exploring the role of family history and lay understanding of genetics on the self‐management of disease
Authors: Lindsay Sally 
Published: May 2010

lindsay s (2010) Journal of Nursing and Healthcare of Chronic Illness2, 135–143 Exploring the role of family history and lay understanding of genetics on the self‐management of diseaseAims and objectives. This project drew a sample from coronary heart disease registries (n = 108) to explore how people incorporate knowledge of lay genetics and family history of a disease to manage their health. Questionnaires and focus groups were analysed to explore whether having a family history of coronary heart disease (CHD) influenced how patients’ self‐managed their health.Background. Although evidence suggests that genes have an important influence on susceptibility to many diseases, little is known about how people use this knowledge to manage their health. Most research on lay perceptions of genetic causes of disease focuses on people atriskof particular genetic condition, rather than on those who already have a disease.Results. Four key themes emerged from the data that people used to understand their heart disease while incorporating family history in different ways including: (1) being ‘doomed’ because of bad genes; (2) not wanting to change health behaviours; (3) wanting to be careful and lead a healthy lifestyle because of a known family history of heart disease and (4) uncertainty of the role of family history in heart disease.Conclusions. Knowledge of family history of the disease influenced how people experienced health and was inherently embedded within social context to shape new meanings of health.Implications for practice. The recommendations based on this research are to encourage health care providers to develop an understanding of patients’ conception of how their disease was caused so they can give them advice that will fit within their framework. It is important to understand the different ways in which patients conceptualise and respond to their illness.
Patients’ decision making in seeking care for suspected malignant melanoma
Authors: Hajdarevic Senada , Hörnsten Åsa , Sundbom Elisabet , Brulin Christin , Schmitt‐Egenolf Marcus 
Published: May 2010

hajdarevic s, hörnsten a, sundbom e, brulin c, schmitt‐egenolf m (2010) Journal of Nursing and Healthcare of Chronic Illness 2, 164–173 Patients’ decision making in seeking care for suspected malignant melanomaAim.  To explore patients’ decision making about seeking care for malignant melanoma (MM).Background.  Unlike other cancers, MM is generally visible and can be easily and cheaply cured if treated in time. It is the delay in diagnosis, most often attributable to the patient rather than to care providers, that results in mortality. Self‐examination of suspicious lesions is important, but it is not a guarantee of immediate care‐seeking, nor is early detection and increased melanoma awareness associated with early care‐seeking.Method.  During 2009, men (n = 10) and women (n = 11) diagnosed with malignant melanoma were interviewed within two years after excision and the text was analysed according to Grounded Theory.Results.  The perception of a critical level of severity, feelings of fear and threat were found to be a key motivator for patients to seek care for suspected melanomas; as soon as sufficient insight into the severity of the disease was achieved, the patient reached a turning point and sought care immediately.Conclusions.  Most of the participants described the process from the discovery of the lesion to the decision to seek care as a time‐consuming inner negotiation about the severity of the disease, personal and social considerations, and interactions with the healthcare system.Relevance to clinical practice.  We analysed the complex reasoning of the patients leading up to the turning point when they sought care. This study illustrates for caregivers the importance of simplifying the pathways to care, emphasising the seriousness of MM, and taking worried patients seriously from their first contact with health care. Health professionals, through their attitudes in contact with patients, can either facilitate or obstruct the patient’s decision making process.
Using AFLP markers and the Geneland program for the inference of population genetic structure
Authors: GUILLOT GILLES , SANTOS FILIPE 
Published: May 2010

AbstractThe use of dominant markers such as amplified fragment length polymorphism (AFLP) for population genetics analyses is often impeded by the lack of appropriate computer programs and rarely motivated by objective considerations. The point of the present note is twofold: (i) we describe how the computer program Geneland designed to infer population structure has been adapted to deal with dominant markers; and (ii) we use Geneland for numerical comparison of dominant and codominant markers to perform clustering. AFLP markers lead to less accurate results than bi‐allelic codominant markers such as single nucleotide polymorphisms (SNP) markers but this difference becomes negligible for data sets of common size (number of individuals n≥100, number of markers L≥200). The latest Geneland version (3.2.1) handling dominant markers is freely available as an R package with a fully clickable graphical interface. Installation instructions and documentation can be found on http://www2.imm.dtu.dk/~gigu/Geneland.
Comparison of the Mantel test and alternative approaches for detecting complex multivariate relationships in the spatial analysis of genetic data
Authors: LEGENDRE PIERRE , FORTIN MARIE‐JOSÉE 
Published: May 2010

AbstractThe Mantel test is widely used to test the linear or monotonic independence of the elements in two distance matrices. It is one of the few appropriate tests when the hypothesis under study can only be formulated in terms of distances; this is often the case with genetic data. In particular, the Mantel test has been widely used to test for spatial relationship between genetic data and spatial layout of the sampling locations. We describe the domain of application of the Mantel test and derived forms. Formula development demonstrates that the sum‐of‐squares (SS) partitioned in Mantel tests and regression on distance matrices differs from the SS partitioned in linear correlation, regression and canonical analysis. Numerical simulations show that in tests of significance of the relationship between simple variables and multivariate data tables, the power of linear correlation, regression and canonical analysis is far greater than that of the Mantel test and derived forms, meaning that the former methods are much more likely than the latter to detect a relationship when one is present in the data. Examples of difference in power are given for the detection of spatial gradients. Furthermore, the Mantel test does not correctly estimate the proportion of the original data variation explained by spatial structures. The Mantel test should not be used as a general method for the investigation of linear relationships or spatial structures in univariate or multivariate data. Its use should be restricted to tests of hypotheses that can only be formulated in terms of distances.
Detecting strong positive selection in the genome
Authors: STEPHAN WOLFGANG 
Published: May 2010

AbstractNew statistical tests have been developed in the past decade that enable us to infer evidence of recent strong positive selection from genome‐wide data on single‐nucleotide polymorphism and to localize the targets of selection in the genome. Based on these tests, past demographic events that led to distortions of the site‐frequency spectrum of variation can be distinguished from selection, in particular if linkage disequilibrium is taken into account. These methods have been successfully applied to species from which complete sequence information and polymorphism data are available, including Drosophila melanogaster, humans, and several plant species. To make full use of the available data, however, the tests that were primarily designed for panmictic populations need to be extended to spatially structured populations.
Applying lessons from China's Wenchuan earthquake to medical rescue following the Yushu earthquake
Authors: Deng Shaolin , Zheng Shangwei , Shi Yingkang 
Published: May 2010

AbstractA 7.1‐magnitude earthquake hit China's Qinghai province—4000 meters above sea level, on April 14, 2010, just 702 days after Wenchuan Earthquake. As of 12:00 on April 19, the death toll stood at 1706, with 256 missing and 12,128 injured. West China Hospital (WCH), a regional state‐level hospital of the Ministry of Health, sent a medical team with relief supplies within the first hour after Yushu earthquake and the team rushed to Yushu in the first day participating golden seventy‐two hours rescue effort. The second day after Yushu earthquake, medical apparatuses and drugs valued at 5 million RMB were delivered to the rescue site and the second batch of medical team were positioned. Within 33 hours of the earthquake, 102 people, including 93 with earthquake‐related injuries and 9 armed police with severe altitude sickness, were send to WCH by air in four batches. WCH organized its medical rescue efforts based on first‐hand experience with medical rescue following Wenchuan earthquake, a series of evidence‐based diagnosis and treatment standards, and “four concentration principles,” namely concentrating the wounded, experts, resources, and treatments. Of the 93 cases with earthquake‐related injuries, 54 were seriously wounded, and in the five days immediately following the earthquake, 58 underwent operations and none died. The experience learned from Wenchuan earthquake have been used, improved and sublimated more rapidly, appropriately, and effectively in the Yushu earthquake medical rescue.
ANALYSIS OF THE SIGNAL COMPLEXITY IN SITAR PERFORMANCES
Authors: SENGUPTA R. , DEY N. , DATTA A. K. , GHOSH D. , PATRANABIS A. 
Published: May 2010

The sitar is perhaps the most well known of the Indian plucked string musical instruments. It has a varying number of strings but 16–20 is usual. When played by an expert, the sitar produces a melodious sound effect. The mode of attachment of strings and or the interaction of the large number of strings, some of them being playing strings, some drone and others sympathetic, create the total acoustic environment, which also includes the global resonance structure of the instrument. This creates a sound whose complexity is difficult to model by usual mathematical methods.Fractal dimension is an effective tool for analysis in such cases. In the present paper D0(fractal dimension), D2(correlation dimension) and also the higher moments are studied for acoustic signals obtained from actual sitar performances. Four such performances are used for the present study. The obeying of power law indicates the presence of non-linearity in the production system. The presence of multifractality is noticed through an examination of relationship between q and Dqand the functional relationship between the Dq's. It was observed that fractal dimension might be used as a measure of signal complexity.
Eventually Periodic Points of Infra-Nil Endomorphisms
Authors: Ha KuYong , Kim HyunJung , Lee JongBum 
Published: May 2010

AbstractHyperbolic toral automorphisms provide important examples of chaotic dynamical systems. Generalizing automorphisms on tori, we study (infra-)nil endomorphisms defined on (infra-)nilmanifolds. In particular, we show that every infra-nil endomorphism has dense eventually periodic points.