bluuebunny/crossref_metadata_2025_split huggingface dataset:
Quaternary evolution of the Jinshan Gorge and Yellow River: Insight from numerical modelling and terrace correlation
Authors: Liu Ya , Wang Jun‐Kang , Zhang Jia‐Fu 
Published: April 2024

AbstractThe evolution of the Jinshan Gorge in the middle reaches of the Yellow River in China has long been a topic of debate. Previous studies have primarily focused on the connection between the Sanmen Gorge and Jinshan Gorge, attributing this connection to the Yellow River's carving through the pre‐Cenozoic bedrock areas of the Sanmen Basin. However, the patterns of knickpoint propagation along the river, influenced by tectonic upheaval and base‐level changes, have yet to be explored, despite their potential to understand fluvial system and canyon evolution. In this study, we address this issue by employing forward and inverse numerical modelling of longitudinal profiles of the Jinshan Gorge of the Yellow River and its tributaries and correlating the river terraces in this reach. We investigated 18 terrace profiles to explore their formation processes. The results demonstrated that the steepness index (Ksn) values and the incision rates of tributaries increase downstream, aligning with the relationship between knickpoint elevation and proximity to the Hancheng Fault. The knickpoint propagation appears to be related to the tectonic activities of the Hancheng Fault before 130 ka and then was influenced by climatic change, resulting in the development of five‐stage knickpoints (named Kp1, Kp2, Kp3, Kp4 and Kp5 from old to young) that correlate with the formation of terraces in the downstream area. We calculated the formation ages of Kps 1–4 to be 1.59 ± 0.06, 0.94 ± 0.11, 0.57 ± 0.31 and 0.22 ± 0.14 Ma, respectively. Kps 1, 2 and 4 correspond to the formation of the Yellow River terraces with the ages of 1.24, 1.12 and 0.24 Ma, which were reported previously. The formation of the oldest knickpoint can be correlated to the establishment of the modern course of the Yellow River in this region, which is deduced to be ~1.59 Ma.
Outcome of early detection approach in control of breast, cervical, and oral cancer: Experience from a rural cancer center in India
Authors: Budukh Atul , Dora Tapas , Sancheti Sankalp , Singh Vikram , Goel Alok , Bagal Sonali , Kaur Amandeep , Manchanda Ishan , Kaur Gurwinder , Gulia Ashish , Chaturvedi Pankaj , Badwe Rajendra 
Published: April 2024

AbstractIn low‐ and middle‐income countries most of the cancer patients attend the hospital at a late stage and treatment completion of these cases is challenging. The early detection program (EDP), in rural areas of Punjab state, India was initiated to identify breast, cervical, and oral cancer at an early stage by raising awareness and providing easy access to diagnosis and treatment. A total of 361 health education programs and 99 early detection clinics were organized. The symptomatic and self‐interested (non‐symptomatic individuals who opted for screening) cases visited the detection clinic. They were screened for breast, cervical, and/or oral cancer. Further diagnosis and treatment of screen‐positive cases were carried out at Homi Bhabha Cancer Hospital (HBCH), Sangrur. Community leaders and healthcare workers were involved in all the activities. The EDP, Sangrur removed barriers between cancer diagnosis and treatment with the help of project staff. From 2019 to 2023, a total of 221,317 populations were covered. Symptomatic and self‐interested individuals attended the breast (1627), cervical (1601), and oral (1111) examinations. 46 breast (in situ‐4.3%; localized‐52.2%), 9 cervical (localized‐77.8%), and 12 oral (localized‐66.7%) cancer cases were detected, and treatment completion was 82.6%, 77.8%, and 50.0%, respectively. We compared cancer staging and treatment completion of cases detected through EDP with the cases attended HBCH from Sangrur district in 2018; the difference between two groups is statistically significant. Due to the early detection approach, there is disease down‐staging and improvement in treatment completion. This approach is feasible and can be implemented to control these cancers in low‐ and middle‐income countries.
Low uptake of Pap test as a cervical cancer screen among Saudi women: Findings from a national survey
Authors: Alfareh Manal , Obeid Dalia , Alhoshan Hala , Basri Rawan , Alhamlan Fatimah S. 
Published: April 2024

AbstractObjectiveThe present study aimed to assess the current knowledge and uptake of Papanicolaou (Pap) tests for cervical screening among Saudi women, including barriers to undergoing the test and the availability of related services.MethodsA cross‐sectional study was conducted using a health questionnaire administered through the Absher portal between April 1, 2019, and March 31, 2020. The questionnaire consisted of five questions and took less than 5 min to complete. Descriptive and inferential statistics were employed to analyze demographic variables, and chi‐square tests were used to examine the association between these variables and Pap test uptake.ResultsThe questionnaire included 8194 Saudi women, with the majority from Makkah (24.40%), Riyadh (21.92%), and Eastern (14.44%) regions. Only 22.52% of respondents had ever received a Pap test, and among them, 17.48% did so based on their physician's recommendation. Private clinics accounted for 10.73% of Pap test locations, while public clinics accounted for 8.97%. The primary reasons for not undergoing the test were lack of knowledge regarding its importance (40.24%) and lack of information from physicians (16.96%). Knowledge of the Pap test as a cervical screening method was significantly associated with marital status, Saudi region, and age group.ConclusionsThis study revealed low awareness of the Pap test for cervical screening among Saudi women, particularly in younger age groups. Targeted educational initiatives are essential to increase awareness and emphasize the significance of regular screenings, especially among younger individuals, to enhance early detection and reduce the burden of cervical cancer in Saudi Arabia.
Prevalence, incidence, and treatment trends of adenomyosis in South Korean women for 15 years: A national population‐based study
Authors: Park Jung Hyun , Chae Kyung‐Hee , Kim Sukil , Park Jung Yoon , Song Jae‐Yen , Chung Youn‐Jee , Kim Mee‐Ran 
Published: April 2024

AbstractObjectiveAdenomyosis is associated with female infertility worldwide. With improvements in imaging methods, such as pelvic magnetic resonance imaging, the diagnosis and treatment of adenomyosis have changed. This study aimed to evaluate the overall prevalence, incidence, and treatment trends of adenomyosis in South Korea using data from the Korean National Health Insurance Service Database (NHIS).MethodsData were collected from the Korean NHIS, a population‐based complete enumeration database. A total of 678 641 women aged 11–55 years diagnosed with adenomyosis (N80.0 ICD‐10 code) from the database from 2002 to 2016 were enrolled. After applying a one‐year look‐back method, 629 592 patients were analyzed to estimate the prevalence, incidence, and treatment trends of adenomyosis.ResultsThe overall prevalence during the study period was 3.86 per 1000 people. The prevalence of adenomyosis has increased from 1.42 per 1000 individuals in 2002 to 7.50 per 1000 individuals in 2016. The crude annual incidence rate of adenomyosis was 1.62 per 1000 people in 2003, which increased to 4.12 per 1000 people in 2016. In addition, the proportion of uterus‐preserving surgeries in adenomyosis treatments has increased from 7.51% to 21.29% over 15 years.ConclusionThe prevalence and incidence of adenomyosis in South Korea increased between 2002 and 2016. Furthermore, the proportion of uterus‐preserving surgeries and progestin prescriptions for adenomyosis treatment has increased. We expect that our findings will raise awareness of the necessity for fertility preservation through earlier diagnosis and proper management of patients with adenomyosis.
Biological particle separation techniques based on microfluidics
Authors: Wang Saijie , Xu Quanchen , Cai Yanwei , Wang Qian , Liu Ying , Wang Dou 
Published: April 2024

AbstractBiological particle separation has wide applications in medical diagnosis, bioengineering, and various other domains. Traditional methods, such as filtration, density gradient centrifugation, and size exclusion chromatography, face many challenges, including low separation resolution, low purity, and the inability to be seamlessly integrated into continuous processes. The development of microfluidics has paved the way for efficient and precise biological particle separation. Microfluidic chip‐based methods can generally be performed continuously and automatically, and microfluidic chips can integrate multilevel operations, including mixing, separation, detection, and so forth, thereby achieving continuous processing of particles at various levels. This review comprehensively investigates biological particle separation techniques based on microfluidic chips. According to the different sources of force effect on the particles during the separation process, they can be divided into active separation, passive separation, and affinity separation. We introduce the principles and device design of these methods respectively, and compare their advantages and disadvantages. For the introduction of each method, we used the most classic and latest research cases as much as possible. Additionally, we discussed the differences between experimental standard particles and biological particles. Finally, we summarized the current limitations and challenges of existing microfluidic separation techniques, while exploring future trends and prospects.
Juvenile probation officers’ lived experiences of collaboration with clinical mental health counselors: An interpretive phenomenological analysis
Authors: Gantt Henrietta Shannon , Diambra Joel , Makupson Myia , Tipton Jennifer 
Published: April 2024

AbstractThis study uses interpretive phenomenological analysis to explore juvenile probation officer's lived experiences of collaborating with counselors. Findings reveal an overview of and the strengths and limitations of existing collaboration. Findings include three higher constructs (a system of multiple parties and arenas, a screening and referral process, and antagonists to collaboration). Super‐ordinate themes include intentional initiation, consistent and responsible communication, and culturally and systemically aware counseling. Subordinate themes include networking and setting relational expectations, reporting information and problem solving, and no judgment and reducing barriers. Direct implications for practicing counselors and future research are provided.
DNA methylation of skeletal muscle function‐related secretary factors identifies FGF2 as a potential biomarker for sarcopenia
Authors: Li Jia‐Wen , Shen Zheng‐Kai , Lin Yu‐Shuang , Wang Zhi‐Yue , Li Mei‐Lin , Sun Hui‐Xian , Wang Quan , Zhao Can , Xu Jin‐Shui , Lu Xiang , Gao Wei 
Published: April 2024

AbstractBackgroundSarcopenia is characterized by progressive loss of muscle mass and function due to aging. DNA methylation has been identified to play important roles in the dysfunction of skeletal muscle. The aim of our present study was to explore the whole blood sample‐based methylation changes of skeletal muscle function‐related factors in patients with sarcopenia.MethodsThe overall DNA methylation levels were analysed by using MethlTarget™ DNA Methylation Analysis platform in a discovery set consistent of 50 sarcopenic older adults (aged ≥65 years) and 50 age‐ and sex‐matched non‐sarcopenic individuals. The candidate differentially methylated regions (DMRs) were further validated by Methylation‐specific PCR (MSP) in another two independent larger sets and confirmed by pyrosequencing. Receiver operating characteristic (ROC) curve analysis was used to determine the optimum cut‐off levels of fibroblast growth factor 2 (FGF2)_30 methylation best predicting sarcopenia and area under the ROC curve (AUC) was measured. The correlation between candidate DMRs and the risk of sarcopenia was investigated by univariate analysis and multivariate logistic regression analysis.ResultsAmong 1149 cytosine‐phosphate‐guanine (CpG) sites of 27 skeletal muscle function‐related secretary factors, 17 differentially methylated CpG sites and 7 differentially methylated regions (DMRs) were detected between patients with sarcopenia and control subjects in the discovery set. Further methylation‐specific PCR identified that methylation of fibroblast growth factor 2 (FGF2)_30 was lower in patients with sarcopenia and the level was decreased as the severity of sarcopenia increased, which was confirmed by pyrosequencing. Correlation analysis demonstrated that the methylation level of FGF2_30 was positively correlated to ASMI (r = 0.372, P < 0.001), grip strength (r = 0.334, P < 0.001), and gait speed (r = 0.411, P < 0.001). ROC curve analysis indicated that the optimal cut‐off value of FGF2_30 methylation level that predicted sarcopenia was 0.15 with a sensitivity of 84.6% and a specificity of 70.1% (AUC = 0.807, 95% CI = 0.756–0.858, P < 0.001). Multivariate logistic regression analyses showed that lower FGF2_30 methylation level (<0.15) was significantly associated with increased risk of sarcopenia even after adjustment for potential confounders including age, sex, and BMI (adjusted OR = 9.223, 95% CI: 6.614–12.861, P < 0.001).ConclusionsOur results suggest that lower FGF2_30 methylation is correlated with the risk and severity of sarcopenia in the older adults, indicating that FGF2 methylation serve as a surrogate biomarker for the screening and evaluation of sarcopenia.
Severe anaphylaxis after chimeric antigen receptor T‐cell injection: a case report
Authors: Morin Sarah , Boroli Filippo , Vandenberghe‐Durr Sophie , Allali Daniele , Masouridi‐Levrat Stavroula , Chalandon Yves , Simonetta Federico 
Published: April 2024

AbstractAnaphylactic reactions at the time of chimeric antigen receptor T (CAR‐T) cell infusion are adverse events that have not been reported in pivotal clinical trials or in real‐world series. We report the case of patient with severe anaphylaxis with cardiac arrest after tisagenlecleucel injection for Diffuse Large B cell Lymphoma, who recovered after resuscitation and intensive care treatment; we also conducted a Food and Drug Administration Adverse Event Reporting System database analysis and found several cases of severe anaphlyaxis after CAR‐T cell injection. Although not reported in pivotal CAR‐T cell studies, anaphylaxis can occur after CAR‐T cell injection, highlighting the need to include anaphylaxis as a possible side effect in future studies.
Cut‐off value for a normal posterior tibial nerve to diagnose tarsal tunnel syndrome amongst people of different race in Pretoria, South Africa
Authors: Roos Natasha , Mahlaola Tintswalo Brenda , Hazell Lynne 
Published: April 2024

AbstractIntroductionPosterior tibial nerve (PTN) cross‐sectional area (CSA) reference values for the diagnosis of tarsal tunnel syndrome (TTS) using ultrasound imaging exist in several countries but not in South Africa (SA). Therefore, the objective was to measure the CSA reference values for PTN in SA.MethodsUltrasound CSA measurements of PTN in both ankles on 112 participants were performed, the mean measurement was recorded, and the effect of race, age, gender, and body mass index (BMI) were recorded.ResultsIn this study, the primary variables age and BMI affect the CSA measurement of the PTN. A positive correlation was found between PTN asymptomatic size and age (r = 0.196, P < 0.05), size and BMI (r = 0.200, P < 0.05). Age (categories) had a mean value of 3.17 for the age group 36–45 years (95% confidence interval (CI) 2.9–3.4). The mean BMI was 30.0 kg/m2 (CI 28.57–31.08). As for the asymptomatic PTN, a mean CSA reference value of 0.10 cm2 was obtained.ConclusionWith increase in age and BMI, a greater PTN measurement will occur. Race appears to be a contributing factor, but further research is needed in this regard. The reference CSA value for normal PTN should be set at 0.10 cm2 for all racial groups for a basic musculoskeletal ultrasound exam protocol in South Africa.
Effects of feedback in manufacturing: A field experiment using smartwatch technology
Authors: Kwasnitschka Daniel , Franke Henrik , Netland Torbjørn H. 
Published: April 2024

AbstractWe investigate the impact of performance feedback delivered to front‐line workers through new digital technologies in the manufacturing sector. Our study takes place in a globally operating manufacturing company that employs smartwatches for real‐time control on the shop floor. In a large‐scale and multi‐site field experiment, we examine 29,669 machine status reports to assess the productivity effects of providing near real‐time feedback to workers via smartwatches. We develop our hypotheses drawing on construal‐level theory and its central idea of psychological distance. Initially, we observe production without feedback to establish comparability between treatment groups. Subsequently, we allocate various combinations of feedback to workers in four separate areas in two manufacturing plants. We manipulate whether the feedback is targeted at individuals with psychologically close feedback (“you did…”) or targeted at the team with relatively psychologically distant feedback (“your team did…”). Furthermore, we vary the message framing: positive framing emphasizes completed tasks, while negative framing emphasizes unfinished tasks. Our findings indicate that positively framed feedback, targeting individuals directly, enhances productivity more than other feedback combinations. Our study contributes new theoretical insights into the interplay between feedback framing and targets in fast‐paced and highly automated batch production environments.
Analyzing the effects of knowledge management on organizational performance through knowledge utilization and sustainability
Authors: Mohaghegh Faezeh , Zaim Halil , Dzenopoljac Vladimir , Dzenopoljac Aleksandra , Bontis Nick 
Published: April 2024

AbstractIn today's turbulent business environment, gaining sustainable competitive advantage requires organizations to manage knowledge capabilities effectively and use resources efficiently. The primary objective of this study is to explore the relationship among knowledge management (KM) processes, including knowledge generation, knowledge codification, and knowledge sharing, with knowledge utilization, sustainability, and organizational performance. The research mainly examines both the direct effect of KM on organizational performance and its indirect effect through sustainability and knowledge utilization. A theoretical framework is introduced and tested using data gathered from companies within the services sector in Kuwait. The results indicate that knowledge utilization and sustainability fully mediate the relationship between KM and organizational performance. Both knowledge utilization and sustainability exert direct and positive effects on organizational performance while being directly influenced by KM. Accordingly, it is suggested that the firms enhance their performance by effectively managing knowledge capabilities appropriately, utilizing knowledge, and investing in sustainability and organizational resources.
Fingerprinting sediment sources in mountainous catchments disturbed by plantation and construction activities in southern China
Authors: Shu Chengbo , Liu Gang , Zhang Qiong , Xu Jinghua , Chen Hong , Dan Chenxi , Wang Xiaokang , Shen Yingli , Liu Ya , Guo Zhen , Liu Dandan , Xia Xiaolin 
Published: April 2024

AbstractThe growing problems of soil erosion and sedimentation due to plantation and construction activities highlight the importance of reliable information on sediment sources with the objectives of designing and implementing targeted management practices. However, reliable information is unavailable for mountainous catchments in southern China. Accordingly, the fingerprinting approach was adopted to quantitatively identify sediment sources in a typical mountainous catchment disturbed by plantation and construction activities in the Dadingshan catchment, Guangdong Province, China. Sensitivity tests were conducted to evaluate the effect of correction factors on the modified model. The results indicated that geochemical elements could be applied for identifying sediment sources within the study catchment. However, the coarse sediment in the catchment posed challenges to the conservative behaviour of tracers. The findings suggested that the primary sediment source is exposed subsoil (51.5 ± 10.0%), followed by plantation topsoil (35.3 ± 16.2%) and wind farms (13.2 ± 10.2%). The mean goodness‐of‐fit value for all sediment samples was 87.1 ± 5.7%. The sediment contributions of various sources varied significantly due to differences in the extent and intensity of human intervention and the main erosion type of each source. Sensitivity analysis revealed that considering the assumption of source normality improved the source apportionment accuracy. However, particle size correction and tracer within‐source variability weighting in the modified mixing model resulted in unusual estimates of the source contributions. This contribution highlights the significance of considering uncertainties in key fingerprinting‐related aspects and emphasizes the need for implementing sediment control strategies in degraded forest environments.
Bilateral Simultaneous Magnetic Resonance–Guided Focused Ultrasound Pallidotomy for Life‐Threatening Status Dystonicus
Authors: Levi Vincenzo , Stanziano Mario , Pinto Carmela , Zibordi Federica , Fedeli Davide , Caldiera Valentina , Cilia Roberto , Golfrè Andreasi Nico , Braccia Arianna , Carozzi Carla , Ciceri Elisa , Grisoli Marina , Gemma Marco , Nazzi Vittoria , DiMeco Francesco , Eleopra Roberto , Zorzi Giovanna 
Published: April 2024

AbstractBackgroundInvasive treatments like radiofrequency stereotactic lesioning or deep brain stimulation of the globus pallidus internus can resolve drug‐resistant status dystonicus (SD). However, these open procedures are not always feasible in patients with SD.ObjectiveThe aim was to report the safety and efficacy of simultaneous asleep bilateral transcranial magnetic resonance–guided focused ultrasound (MRgFUS) pallidotomy for life‐threatening SD.MethodsWe performed bilateral simultaneous MRgFUS pallidotomy under general anesthesia in 2 young patients with pantothenate kinase–associated neurodegeneration and GNAO1 encephalopathy. Both patients had medically refractory SD and severe comorbidities contraindicating open surgery.ResultsSD resolved at 4 and 12 days after MRgFUS, respectively. Adverse events (intraoperative hypothermia and postoperative facial paralysis) were mild and transient.ConclusionBilateral simultaneous MRgFUS pallidotomy under general anesthesia is safe and may be a valid alternative therapeutic option for fragile patients. Further studies are needed to assess long‐term efficacy of the procedure.