bluuebunny/crossref_metadata_2025_split huggingface dataset:
Poor sleep quality and associated factors among adult chronic kidney disease patients
Authors: Gela Yibeltal Yismaw , Limenh Liknaw Workie , Simegn Wudneh , Ayenew Wondim , Chanie Gashaw Sisay , Seid Abdulwase Mohammed , Beyna Alemante Tafese , Esubalew Dereje , Mitku Melese Legesse , Mengesha Assefa Kebad , Melese Mihret 
Published: May 2024

BackgroundPoor sleep quality is a common concern in chronic kidney disease (CKD) patients, which can accelerate the progression of chronic renal disease and negatively impact their health-related quality of life, potentially leading to greater morbidity and mortality rates. It can also have an effect on the immune system, cognitive function, and emotional well-being of CKD patients. Furthermore, poor sleep quality may contribute to drug noncompliance and decreased participation in the entire treatment plan. Nonetheless, no research has been undertaken in Ethiopia on the prevalence of poor sleep quality and its associated factors among CKD patients.ObjectiveThis study aimed to assess the prevalence of poor quality of sleep and associated factors among chronic kidney disease patients at the University of Gondar Comprehensive Specialized and Felege Hiwot Referral Hospitals in 2020.MethodsA cross-sectional study design was implemented at the University of Gondar Comprehensive Specialized and Felege Hiwot Referral Hospitals between February and April 2020. The study participants were chosen through systematic random sampling techniques. The Pittsburgh Sleep Quality Index (PSQI), a validated assessment tool, was utilized to measure sleep quality. A PSQI total score &gt; 5 was used as an indicator of poor sleep quality. Subsequently, the data obtained were entered into Epi Data version 3.0 and then transferred to STATA 14 for analysis. Both bivariable and multivariable binary logistic regression analyses were performed to recognize factors associated with poor sleep quality. In the multivariable logistic regression analysis, variables demonstrating a p-value of ≤0.05 were considered statistically associated to poor sleep quality.ResultsIn this study, 424 CKD patients were included. Among screened CKD patients, 42.9% tested positive for poor sleep quality with a 95% CI (38 to 47%). Independent predictors of poor sleep quality among CKD patients were common mental disorder [AOR = 1.8, 95% CI (1.19–2.89)], anemia [AOR = 2.7, 95% CI (1.71–4.36)], declined eGFR between 60 and 89.9 [AOR = 1.6; 95% CI (2.28–5.54)], 30–59.9 [AOR = 2.6, 95% CI (1.53–4.43)], and ≤ 30 [AOR = 3.8, 95% CI (1.17–12.61)], age &gt; 50 years [AOR = 1.7(1.11–2.69)] and duration of disease 2.9 [AOR = 2.9, 95% CI (1.77–4.90)].ConclusionIn our study, almost 1 out of 2 CKD patients assessed for poor sleep quality tested positive. It was noted that poor sleep quality was more frequent among CKD patients with common mental disorders, anemia, decreased eGFR levels, individuals aged over 50 years, and those with a longer duration of the disease. Consequently, it’s advised to regularly screen these CKD patients for poor sleep quality.
High prevalence of dengue, Zika, and chikungunya viruses in blood donors during a dengue outbreak and an endemic period in Colombia
Authors: Cáceres Munar Brian Alejandro , Urbina Adriana , Ortíz Tatiana , Rodríguez Ayda , Fernández Olga Lucía , Ospina Luisa Fernanda , Flórez Iris , Uribe Dora , Alvarado Celia , Calvo Eliana Patricia , Delgado Félix Giovanni , Castellanos Jaime Eduardo 
Published: May 2024

ObjectiveArboviruses pose a challenge in ensuring the supply of pathogen-free blood components because they are not routinely screened in blood banks, and blood components from infected asymptomatic donors could be transfused. This study aimed to detect and characterize arboviral infections in Colombian blood donors.MethodsIn a cross-sectional study, the prevalence of dengue (DENV), Zika (ZIKV), and chikungunya (CHIKV) viruses and co-infections of blood donors were compared between an epidemic period (November 2019–February 2020, n = 462) and an endemic period (November 2021–August 2022, n = 1,119). Viral RNA from each donor serum was purified, and the viruses were detected using a previously standardized multiplex hemi-nested RT-PCR protocol. Subsequently, donors who tested positive were surveyed 15 days after the detection of the virus to identify clinical characteristics related to the arboviral infection. The prevalences of each virus were presented as percentages and compared between epidemic and endemic periods.ResultsSignificantly higher prevalences were found in the epidemic period compared with the endemic period for DENV (14.5 vs. 1.9%), ZIKV (7.8 vs. 0.3%), CHIKV (8 vs. 3.3%), and co-infections (4.3 vs. 0.2%). The survey response rate of positive donors in the two periods was 83/175 (47%). In total, 57% of the donors surveyed were asymptomatic. Symptomatic donors most frequently reported headache (31%), malaise (13%), arthralgia (10%), and fever/chills (8%).ConclusionThe prevalence observed in epidemic and endemic periods was higher than that reported in other studies in the Americas. The high proportion of asymptomatic cases found, in addition to the mild and nonspecific manifestations among the symptomatic, may limit the effectiveness of the donor selection criteria used to mitigate the risk of transfusion-transmitted arboviruses.
Woodfordia fruticosa fermented with lactic acid bacteria impact on foodborne pathogens adhesion and cytokine production in HT-29 cells
Authors: Lee Eon-Bee , Lee Kyubae 
Published: May 2024

IntroductionThe study into the interplay between foodborne pathogens and human health, particularly their effects on intestinal cells, is crucial. The importance of lactic acid bacteria (LAB) in promoting a healthy balance of gut microbiota, inhibiting harmful bacteria, and supporting overall gastrointestinal health is becoming more apparent.MethodsOur study delved into the impact of fermenting Woodfordia fruticosa (WF), a plant known for its antimicrobial properties against gastrointestinal pathogens, with LAB. We focused on the influence of this fermentation process on the binding of foodborne pathogens to the gut lining and cytokine production, aiming to enhance gut health and control foodborne infections in HT-29 cells.Results and discussionPost-fermentation, the WF exhibited improved antimicrobial effects when combined with different LAB strains. Remarkably, the LAB-fermented WF (WFLC) substantially decreased the attachment of pathogens such as L. monocytogenes (6.87%  ±  0.33%) and V. parahaemolyticus (6.07%  ±  0.50%) in comparison to the unfermented control. Furthermore, WFLC was found to upregulate IL-6 production in the presence of pathogens like E. coli O157:H7 (10.6%) and L. monocytogenes (19%), suggesting it may activate immune responses. Thus, LAB-fermented WF emerges as a potential novel strategy for fighting foodborne pathogens, although additional studies are warranted to thoroughly elucidate WF’s phytochemical profile and its contribution to these beneficial outcomes
Key developments and hotspots of exosomes in Alzheimer’s disease: a bibliometric study spanning 2003 to 2023
Authors: Liu Siyu , Geng Daoying 
Published: May 2024

BackgroundAlzheimer’s disease (AD) is a degenerative illness of the central nervous system that is irreversible and is characterized by gradual behavioral impairment and cognitive dysfunction. Researches on exosomes in AD have gradually gained the attention of scholars in recent years. However, the literatures in this research area do not yet have a comprehensive visualization analysis. The aim of this work is to use bibliometrics to identify the knowledge constructs and investigate the research frontiers and hotspots related to exosomes in AD.MethodsFrom January 2003 until June 2023, we searched the Web of Science Core Collection for literature on exosomes in AD. We found 585 papers total. The bibliometric study was completed using VOSviewer, the R package “bibliometrix,” and CiteSpace. The analysis covered nations, institutions, authors, journals, and keywords.ResultsFollowing 2019, the articles on exosomes in AD increased significantly year by year. The vast majority of publications came from China and the US. The University of California System, the National Institutes of Health, and the NIH National Institute on Aging in the US were the primary research institutions. Goetzl Edward J. was frequently co-cited, while Kapogiannis Dimitrios was the most prolific author in this discipline with the greatest number of articles. Lee Mijung et al. have been prominent in the last two years in exosomes in AD. The Journal of Alzheimer’s Disease was the most widely read publication, and Alzheimers &amp; Dementia had the highest impact factor. The Journal of Biological Chemistry, Proceedings of the National Academy of Sciences of the United States of America, and Journal of Alzheimer’s Disease were the three journals with more than 1,000 citations. The primary emphasis of this field was Alzheimer’s disease, exosomes, and extracellular vesicles; since 2017, the number of phrases pertaining to the role of exosomes in AD pathogenesis has increased annually. “Identification of preclinical Alzheimer’s disease by a profile of pathogenic proteins in neurally derived blood exosomes: a case–control study” was the reference with the greatest citing power, indicating the future steered direction in this field.ConclusionUsing bibliometrics, we have compiled the research progress and tendencies on exosomes in Alzheimer’s disease for the first time. This helps determine the objectives and paths for future study.
A nomogram for predicting cerebral white matter lesions in elderly men
Authors: Pei Yi-Feng , Li Xian-Dong , Liu Quan-Ying , Zhang Chu-Wei , Wang Yi-Han , Chen Ming-Rui , Chen Hui-Sheng 
Published: May 2024

ObjectiveThis study aimed to develop a nomogram tool to predict cerebral white matter lesions (WMLs) in elderly men.MethodsBased on a retrospective cohort from January 2017 to December 2019, a multivariate logistic analysis was performed to construct a nomogram for predicting WMLs. The nomogram was further validated using a follow-up cohort between January 2020 and December 2022. The calibration curve, receiver operating characteristics (ROC) curves, and the decision curves analysis (DCA) were used to evaluate discrimination and calibration of this nomogram.ResultA total of 436 male patients were enrolled in this study, and all 436 patients were used as the training cohort and 163 follow-up patients as the validation cohort. A multivariate logistic analysis showed that age, cystatin C, uric acid, total cholesterol, platelet, and the use of antiplatelet drugs were independently associated with WMLs. Based on these variables, a nomogram was developed. The nomogram displayed excellent predictive power with the area under the ROC curve of 0.951 [95% confidence interval (CI), 0.929–0.972] in the training cohort and 0.915 (95% CI, 0.864–0.966) in the validation cohort. The calibration of the nomogram was also good, as indicated by the Hosmer–Lemeshow test with p-value of 0.594 in the training cohort and 0.178 in the validation cohort. The DCA showed that the nomogram holds good clinical application value.ConclusionWe have developed and validated a novel nomogram tool for identifying elderly men at high risk of WMLs, which exhibits excellent predictive power, discrimination, and calibration.
Superior frontal sulcus: a non-eloquent corridor for cavernomas of the internal capsule
Authors: Pereira Felipe Salvagni , Jiménez Luis Ángel Canache , Aguaisa Edgar David Tenelema , Apaza-Tintaya Rene Alejandro , Biondi-Soares Luis Gustavo , Paitán Alexander Feliciano Vilcahuamán , Soto Pedro Henrique Teixeira , Wuo-Silva Raphael , Chaddad-Neto Feres 
Published: May 2024

IntroductionDeep cavernomas of eloquent areas, located in the region of the basal nuclei and thalamus, account for 9 to 36% of these encephalic vascular malformations. Internal capsule cavernomas are particularly challenging, as they are surrounded by important projection fibers and their manipulation can lead to permanent deficits. To demonstrate through surgical cases that cavernomas of the internal capsule can be approached by frontal craniotomy, via the superior frontal sulcus, in a curative manner and with low morbidity.MethodsWe presented two cases of cavernomas of the internal capsule operated, whose treatment was microsurgical resection via frontal craniotomy and access to the lesion via the superior frontal sulcus, described step-by-step. To elucidate the rationale behind the decision, we used preoperative images with an emphasis on the patients’ tractography and the importance of comparing these images with anatomical specimens dissected in the neuroanatomy and microsurgery laboratory.ResultsThe two cases of internal capsule cavernomas, one in the anterior limb and the other in the posterior limb, were treated surgically via the superior frontal sulcus.DiscussionBoth patients showed radiological cure and clinical improvement in the post-operative segment. The patient consented to the procedure and to the publication of his/her image. Treatment of internal capsule cavernomas via the superior frontal sulcus has proven to be a safe and effective option.
Electroencephalography-based biological and functional characteristics of spinal cord injury patients with neuropathic pain and numbness
Authors: Wang Dezheng , Zhang Xinting , Xin Chen , Wang Chongfeng , Yue Shouwei , Guo Dongju , Wang Wei , Zhang Yang , Xu Fangzhou 
Published: May 2024

ObjectivesTo identify potential treatment targets for spinal cord injury (SCI)-related neuropathic pain (NP) by analysing the differences in electroencephalogram (EEG) and brain network connections among SCI patients with NP or numbness.Participants and methodsThe EEG signals during rest, as well as left- and right-hand and feet motor imagination (MI), were recorded. The power spectral density (PSD) of the θ (4–8 Hz), α (8–12 Hz), and β (13–30 Hz) bands was calculated by applying Continuous Wavelet Transform (CWT) and Modified S-transform (MST) to the data. We used 21 electrodes as network nodes and performed statistical measurements of the phase synchronisation between two brain regions using a phase-locking value, which captures nonlinear phase synchronisation.ResultsThe specificity of the MST algorithm was higher than that of the CWT. Widespread non-lateralised event-related synchronization was observed in both groups during the left- and right-hand MI. The PWP (patients with pain) group had lower θ and α bands PSD values in multiple channels of regions including the frontal, premotor, motor, and temporal regions compared with the PWN (patients with numbness) group (all p &lt; 0.05), but higher β band PSD values in multiple channels of regions including the frontal, premotor, motor, and parietal region compared with the PWN group (all p &lt; 0.05). During left-hand and feet MI, in the lower frequency bands (θ and α bands), the brain network connections of the PWP group were significantly weaker than the PWN group except for the frontal region. Conversely, in the higher frequency bands (β band), the brain network connections of the PWP group were significantly stronger in all regions than the PWN group.ConclusionThe differences in the power of EEG and network connectivity in the frontal, premotor, motor, and temporal regions are potential biological and functional characteristics that can be used to distinguish NP from numbness. The differences in brain network connections between the two groups suggest that the distinct mechanisms for pain and numbness.
Right prefrontal activation associated with deviations from expected lipstick texture assessed with functional near-infrared spectroscopy
Authors: Hirabayashi Kazue , Kawabata Duncan Keith , Tagai Keiko , Kyutoku Yasushi , Dan Ippeita 
Published: May 2024

IntroductionThere is a continuous consumer demand for ever superior cosmetic products. In marketing, various forms of sensory evaluation are used to measure the consumer experience and provide data with which to improve cosmetics. Nonetheless, potential downsides of existing approaches have led to the exploration of the use of neuroimaging methods, such as functional near-infrared spectroscopy (fNIRS), to provide addition information about consumers' experiences with cosmetics. The aim of the present study was to investigate the feasibility of a real-time brain-based product evaluation method which detects the incongruency between a product, in this case lipstick, and a consumer's expectations.MethodThirty healthy, female, habitual lipstick users were asked to apply six different lipsticks varying in softness and to rate the softness of and their willingness to pay (WTP) for each lipstick. Cerebral hemodynamic responses in frontal areas were measured with fNIRS during lipstick application and analyzed using the general linear model (GLM). Incongruency scores between softness and expectation were calculated in order to understand how far removed each lipstick was from a participant's optimal softness preference. The correlation between brain activation (beta scores) during the application of each lipstick and the respective incongruency scores from each participant were acquired using semi-partial correlation analysis, controlling for the effects of WTP.ResultsWe revealed a significant intra-subject correlation between incongruency scores and activation in the right inferior frontal gyrus (IFG). This confirms that as the texture incongruency scores increased for the lipstick samples, activation in each individual's right IFG also increased.ConclusionThe correlation observed between incongruency perceived by participants and activation of the right IFG not only suggests that the right IFG may play an important role in detecting incongruity when there is a discrepancy between the perceived texture and the consumer's expectations but also that measuring activity in the IFG may provide a new objective measurement of the consumer experience, thus contributing to the development of superior cosmetics.
Compassion, secure flourishing, and organizational commitment of managers
Authors: Ford Mari , Rothmann Sebastiaan , Van Zyl Llewellyn Ellardus 
Published: May 2024

IntroductionCompassion is important for facilitating individual wellbeing and commitment. However, little is known about its importance and function within organizational contexts. This study aimed to assess the associations between compassion for others, experienced compassion, secure flourishing, and organizational commitment within a sample of managers from South Africa. Given that Pommier's Compassion Scale (which was used in this study) was not previously validated in South Africa, the study investigated its factorial validity and measurement invariance across genders.MethodsA cross-sectional online survey-based research design with a purposive sampling strategy was employed to sample 390 managers to participate in this study. The Compassion Scale, Experienced Compassion Scale, Secure Flourishing Index and Organizational Commitment Scales were administered. A competing measurement modeling strategy was employed to test the factorial validity of the compassion scale. McDonalds Omega was computed to test the reliability of the instrument. Measurement invariance was employed to test the factorial equivalence of the compassion scale across genders. A structural model was tested to determine the relationships between factors.ResultsThe results supported a bifactor ESEM Model with one general compassion factor and four specific subscale factors (mindfulness, kindness, indifference, and common humanity). Managers' general compassion and belief in common humanity (a compassion subscale factor) significantly affected their secure flourishing, yet not their organizational commitment. Compassion experienced from others, however, had a strong and significant effect on their secure flourishing and organizational commitment.DiscussionThe results indicate that the Compassion Scale is a valid, gender invariant, and reliable measure of compassion for others, and is suitable for organizational research. Giving and receiving compassion at work has significant benefits for managers and organizations.
The modulation effect of cognition on mentalization in late-life depression: a study of gaze perception—a potential screening tool for high-risk group of late-life depression
Authors: Ngan Sze Ting Joanna , Cheng Calvin Pak Wing , Chan Wai Chi , Tsui Kam Hung Harry , Chan Sau Man Corine , Chan Kit Wa Sherry 
Published: May 2024

IntroductionImpairment in mentalization is implicated in the development and maintenance of depression. Major depressive disorders showed significant impairment in social cognition and such impairment appears to be positively associated with the severity of depression. Self-referential gaze perception (SRGP), a measurement of mentalization, was predominantly measured in patients with psychosis but rarely examined in late-life depression (LLD).MethodsTo assess the effect of cognition on the interpretation bias of mentalization, 29 LLD patients and 29 healthy controls were asked to judge if various gaze directions were directed to self in SRGP.ResultsPatients with better cognition showed less unambiguous-SRGP bias than those with worse cognitive scores; this difference was not found in healthy controls. Global cognition and executive function contributed to the SRGP rate in patients.ConclusionThe current study is the first study to explore the relationship between cognition and SRGP in the LLD population. Our study findings suggested that the cognitive function of LLD patients may contribute to the modulation of interpretation bias, which in turn underlie the role of SRGP bias. Greater SRGP bias in patients may reflect social cognition deterioration, impairing the social interaction and functioning of LLD patients. This highlights the need for early intervention and cognitive decline identification to facilitate better prognosis and treatment effectiveness; thus, further studies could navigate the potential of SRGP task as a screening tool for high-risk group of LLD likely to develop dementia.
A qualitative investigation of the Montgomery–Åsberg depression rating scale: discrepancies in rater perceptions and data trends in remote assessments of rapid-acting antidepressants in treatment resistant depression
Authors: Capodilupo Gianna , Blattner Raymond , Must Anita , Navarro Silvia Gamazo , Opler Mark 
Published: May 2024

IntroductionDespite the development of many successful pharmaceutical interventions, a significant subset of patients experience treatment-resistant depression (TRD). Ketamine and its derivatives constitute a novel therapeutic approach to treat TRD; however, standard tools, such as the Montgomery–Åsberg Depression Rating Scale (MADRS) are still being used to measure symptoms and track changes.MethodsThe aim of this study was to review item-level differences between rate of data change (MADRS score) and rater-weighted perception of the most useful items for assessing change in symptoms while remotely conducting the 10-item version of the MADRS in TRD in a clinical trial of rapid-acting antidepressants. Two studies of rapid-acting antidepressants in the treatment of TRD were used to identify item-scoring trends when MADRS is administered remotely and repeatedly (733 subjects across 10 visits). Scoring trends were evaluated in tandem to a rater survey completed by 75 raters. This was completed to gain insight on MADRS items’ perceived level of helpfulness when assessing change of symptoms in rapid-acting antidepressant trials.ResultsMADRS items ‘Reduced sleep’, ‘Apparent sadness’, and ‘Pessimistic thoughts’ were found to have the greatest average data change by visit, while raters ranked ‘Reported sadness’, ‘Lassitude’ and ‘Apparent sadness’ as the most helpful items when assessing symptom change.DiscussionThe diversion between rate of data-change ranking and rater perception of helpfulness could be related to difficulty in assessing specific items, to the novel treatment itself, and/or to the sensitivity to symptom change to which raters are accustomed in traditional antidepressant treatments.