bluuebunny/crossref_metadata_2025_split huggingface dataset:
Potential role of blood pressure variability and plasma neurofilament light in the mechanism of comorbidity between Alzheimer's disease and cerebral small vessel disease
Authors: Li Qin , Su Shu , Feng Yuxue , Jia Meng , Zhan Jiehong , Liao Zixuan , Li Jiayu , Li Xiaofeng ,   for the Alzheimer's Disease Neuroimaging Initiative
Published: June 2024

AbstractINTRODUCTIONLong‐term blood pressure variability (BPV) and plasma neurofilament light (pNfL) have been identified as potential biomarkers for Alzheimer's disease (AD) and cerebral small vessel disease (CSVD). However, the relationship between BPV, pNfL, and their association with the comorbidity of AD and CSVD remains unknown.METHODSParticipants with normal cognition and mild cognitive impairment from the Alzheimer's Disease Neuroimaging Initiative study were included in the data analysis. Linear mixed‐effects regression models and causal mediation analyses were conducted to investigate the relationship among BPV, pNfL, comorbidity‐related brain structural changes (hippocampal atrophy and white matter hyperintensities [WMH]), and cognitive function.RESULTSBPV was associated with pNfL, volumes of hippocampus and WMH, and cognition. pNfL mediated the effects of BPV on brain structural changes and cognition.DISCUSSIONOur findings suggest a potential role of BPV and pNfL in the mechanism of comorbidity between AD and CSVD, underscoring the importance of BPV intervention in the general population.Highlights
Individuals with both Alzheimer's disease (AD) and cerebral small vessel disease (CSVD) pathologies had elevated blood pressure variability (BPV) and plasma neurofilament light (pNfL).
The association between different components of BPV and brain structural changes may vary.
BPV was associated with pNfL levels independent of average blood pressure.
pNfL mediated the effects of BPV on comorbidity‐related brain structural changes and cognitive performance.
Apolipoprotein E4 interferes with lipid metabolism to exacerbate depression‐like behaviors in 5xFAD mice
Authors: Gong Yanju , Li Mingfeng , Liu Min , Wu Xinghan , Li Yanhong , Qin Chuan , Zhang Ling 
Published: June 2024

AbstractBackgroundApolipoprotein E4 (ApoE4) allele is the strongest genetic risk factor for late‐onset Alzheimer's disease, and it can aggravate depressive symptoms in non‐AD patients. However, the impact of ApoE4 on AD‐associated depression‐like behaviors and its underlying pathogenic mechanisms remain unclear.MethodsThis study developed a 5xFAD mouse model overexpressing human ApoE4 (E4FAD). Behavioral assessments and synaptic function tests were conducted to explore the effects of ApoE4 on cognition and depression in 5xFAD mice. Changes in peripheral and central lipid metabolism, as well as the levels of serotonin (5‐HT) and γ‐aminobutyric acid (GABA) neurotransmitters in the prefrontal cortex, were examined. In addition, the protein levels of 24‐dehydrocholesterol reductase/glycogen synthase kinase‐3 beta/mammalian target of rapamycin (DHCR24/GSK3β/mTOR) and postsynaptic density protein 95/calmodulin‐dependent protein kinase II/brain‐derived neurotrophic factor (PSD95/CaMK‐II/BDNF) were measured to investigate the molecular mechanism underlying the effects of ApoE4 on AD mice.ResultsCompared with 5xFAD mice, E4FAD mice exhibited more severe depression‐like behaviors and cognitive impairments. These mice also exhibited increased amyloid‐beta deposition in the hippocampus, increased astrocyte numbers, and decreased expression of depression‐related neurotransmitters 5‐HT and GABA in the prefrontal cortex. Furthermore, lipid metabolism disorders were observed in E4FAD, manifesting as elevated low‐density lipoprotein cholesterol and reduced high‐density lipoprotein cholesterol in peripheral blood, decreased cholesterol level in the prefrontal cortex, and reduced expression of key enzymes and proteins related to cholesterol synthesis and homeostasis. Abnormal expression of proteins related to the DHCR24/GSK3β/mTOR and PSD95/CaMK‐II/BDNF pathways was also observed.ConclusionThis study found that ApoE4 overexpression exacerbates depression‐like behaviors in 5xFAD mice and confirmed that ApoE4 reduces cognitive function in these mice. The mechanism may involve the induction of central and peripheral lipid metabolism disorders. Therefore, modulating ApoE expression or function to restore cellular lipid homeostasis may be a promising therapeutic target for AD comorbid with depression. This study also provided a better animal model for studying AD comorbid with depression.
Divergent Synthesis of Enantioenriched Silicon‐Stereogenic Benzyl‐, Vinyl‐ and Borylsilanes via Asymmetric Aryl to Alkyl 1,5‐Palladium Migration
Authors: Shi Yufeng , Qin Ying , Li Zhong‐Qiu , Xu Yize , Chen Shuhan , Zhang Jinyu , Li Yu‐An , Wu Yaxin , Meng Fei , Zhong Yu‐Wu , Zhao Dongbing 
Published: June 2024

AbstractFunctionalization of Si‐bound methyl group provides an efficient access to diverse organosilanes. However, the asymmetric construction of silicon‐stereogenic architectures by functionalization of Si‐bound methyl group has not yet been described despite recent significant progress in producing chiral silicon. Herein, we disclosed the enantioselective silylmethyl functionalization involving the aryl to alkyl 1,5‐palladium migration to access diverse naphthalenes possessing an enantioenriched stereogenic silicon center, which are inaccessible before. It is worthy to note that the realization of asymmetric induction at the step of metal migration itself remains challenging. Our study constitutes the first enantioselective aryl to alkyl 1,5‐palladium migration reaction. The key to the success is the discovery and fine‐tuning of the different substituents of α,α,α,α‐tetraaryl‐1,3‐dioxolane‐4,5‐dimethanol (TADDOL)‐based phosphoramidites, which ensure the enantioselectivity and desired reactivity.
Photocatalytic Cracking of non‐Biodegradable Plastics to Chemicals and Fuels
Authors: Su Kaiyi , Gao Tengshijie , Tung Chen‐Ho , Wu Li‐Zhu 
Published: June 2024

AbstractPlastic pollution is worsening the living conditions on Earth, primarily due to the toxicity and stability of non‐biodegradable plastics (NBPs). Photocatalytic cracking of NBPs is emerging as a promising way to cleave inert C−C bonds and abstract the carbon atoms from these wastes into valuable chemicals and fuels. However, controlling these processes is a huge challenge, ascribed to the complicated reactions of various NBPs. Herein, we summarize recent advances in the CO2 and carbon‐radical‐mediated photocatalytic cracking of NBPs, with an emphasis on the pivotal intermediates. The CO2‐mediated cracking proceeded with indiscriminate C−H/C−C bond cleavage of NBPs and tandem photoreduction of CO2, while carbon‐radical‐mediated cracking was realized by the prior activation of C−H bonds for selective C−C bond cleavage of NBPs. Catalytic generation and conversion of different intermediates greatly depend on the kinds of active species and the structure of photocatalysts under irradiation. Meanwhile, the fate of a specific intermediate is compared with small molecule activation to reveal the key problems in the cracking of NBPs. Finally, the challenges and potential directions are discussed to improve the overall efficiency in the photocatalytic cracking of NBPs.
Molecular Engineering of Metal–Organic Frameworks for Boosting Photocatalytic Hydrogen Peroxide Production
Authors: Tang Yu‐Ying , Luo Xiao , Xia Ri‐Qin , Luo Jie , Peng Su‐Kao , Liu Zhen‐Na , Gao Qiang , Xie Mo , Wei Rong‐Jia , Ning Guo‐Hong , Li Dan 
Published: June 2024

AbstractThe development of novel metal–organic frameworks (MOFs) as efficient photocatalysts for hydrogen peroxide production from water and oxygen is particularly interesting, yet remains a challenge. Herein, we have prepared four cyclic trinuclear units (CTUs) based MOFs, exhibiting good light absorption ability and suitable band gaps for photosynthesis of H2O2. However, Cu‐CTU‐based MOFs are not able to photocatalyzed the formation of H2O2, while the alteration of metal nodes from Cu‐CTU to Ag‐CTU dramatically enhances the photocatalytic performance for H2O2 production and the production rates can reach as high as 17476 μmol g−1 h−1 with an apparent quantum yield of 4.72 %, at 420 nm, which is much higher than most reported MOFs. The photocatalytic mechanism is comprehensively studied by combining the isotope labeling experiments and DFT calculation. This study provides new insights into the preparation of MOF photocatalysts with high activity for H2O2 production through molecular engineering.
A Fragment‐Based Competitive 19F LB‐NMR Platform For Hotspot‐Directed Ligand Profiling
Authors: McCarthy William J. , Thomas Sherine E. , Olaleye Tayo , Boland Jennifer A. , Floto R. Andres , Williams Glyn , Blundell Tom L. , Coyne Anthony G. , Abell Chris 
Published: June 2024

AbstractLigand binding hotspots are regions of protein surfaces that form particularly favourable interactions with small molecule pharmacophores. Targeting interactions with these hotspots maximises the efficiency of ligand binding. Existing methods are capable of identifying hotspots but often lack assays to quantify ligand binding and direct elaboration at these sites. Herein, we describe a fragment‐based competitive 19F Ligand Based NMR (LB‐NMR) screening platform that enables routine, quantitative ligand profiling focused at ligand‐binding hotspots. As a proof of concept, the method was applied to 4′‐phosphopantetheine adenylyltransferase (PPAT) from Mycobacterium abscessus (Mabs). X‐ray crystallographic characterisation of the hits from a 960‐member fragment screen identified three ligand‐binding hotspots across the PPAT active site. From the fragment hits a collection of 19F reporter candidates were designed and synthesised. By rigorous prioritisation and use of optimisation workflows, a single 19F reporter molecule was generated for each hotspot. Profiling the binding of a set of structurally characterised ligands by competitive 19F LB‐NMR with this suite of 19F reporters recapitulated the binding affinity and site ID assignments made by ITC and X‐ray crystallography. This quantitative mapping of ligand binding events at hotspot level resolution establishes the utility of the fragment‐based competitive 19F LB‐NMR screening platform for hotspot‐directed ligand profiling
Analysis of HZSM‐5 molecular sieve particles attrition behavior under fluidized conditions
Authors: Huang Zhiwei , Gao Feng , Miao Yang 
Published: June 2024

AbstractThe attrition behavior of HZSM‐5 zeolite catalyst particles at room temperature was investigated in a laboratory‐scale fluidized bed. The effects of three fluidization conditions on particle attrition were investigated, and a new attrition model was proposed. The results demonstrate that the attrition rate is inversely proportional to the initial particle size and proportional to the apparent gas velocity. After increasing to 80 μm and .3 m/s respectively, they are no longer the main factor affecting attrition. The effect of bed pressure on attrition rate is nonlinear, and the lowest attrition rate is obtained when the diameter‐height ratio is 1:1. Unsteady attrition stage can be divided into initial stage and deceleration stage. Surface delamination dominates particle attrition throughout the whole process, and bulk fracture is the dominant mechanism only in the deceleration stage. Based on the Gwyn equation, a new attrition model in the form of cubic polynomial is established with the ratio of total attrition rate to unstable attrition rate P as a parameter. The model has high accuracy and repeatability and is suitable for various fluidization conditions. It can effectively describe the attrition process and change rule of particles and reasonably predict the fluidization attrition rate of particles.
Anticancer perspectives of monocarbonyl analogs of curcumin: A decade (2014–2024) review
Authors: Nagargoje Amol A. , Deshmukh Tejshri R. , Shaikh Mubarak H. , Khedkar Vijay M. , Shingate Bapurao B. 
Published: June 2024

AbstractMonocarbonyl analogs of curcumin (MACs) represent structurally modified versions of curcumin. The existing literature indicates that MACs exhibit enhanced anticancer properties compared with curcumin. Numerous research articles in recent years have emphasized the significance of MACs as effective anticancer agents. This review focuses on the latest advances in the anticancer potential of MACs, from 2014 to 2024, including discussions on their mechanism of action, structure–activity relationship (SAR), and in silico molecular docking studies.
Unraveling the link between Type II supernova luminosity and host galaxy velocity dispersion
Authors: Hernández Flores A. , Olivares E. F. , Morelli L. , Wiseman P. , Gutierrez C. P. 
Published: June 2024

AbstractType II supernovae (SNe II) have emerged as valuable cosmological probes, serving as alternative and independent tools to Type Ia supernova (SN Ia) cosmology. However, the Hubble diagram dispersion for SNe II is significantly larger than for SNe Ia. In this study, we investigate the SN II luminosity and the host galaxy velocity dispersion with the purpose of improving the scatter in the SN II Hubble diagram. We selected a sample of SNe II discovered by the Dark Energy Survey (DES), and we measured the spectra of their host galaxies using the VLT/FORS2 and Magellan‐Baade/MagE spectrographs. From those galaxy spectra, we calculated the stellar velocity dispersion in the central region. Using the effective Sérsic radius from the DES imaging, we standardized the velocity dispersion values to a common aperture. From their i‐band light curves, we determined a characteristic plateau brightness for our SNe. For this purpose, we developed an algorithm designed to parameterize the plateau phase. After computing the SN absolute magnitudes using the standard cosmology, we found a modest correlation with the host galaxy velocity dispersion (). These findings could significantly contribute to SN II cosmology, paving the way for SNe II as more robust cosmological probes.
Microelectrode investigation of iron and copper surfaces aged in presence of monochloramine
Authors: Gonzalez Beatriz C. , Liggett Jennifer E. , Lytle Darren A. , Lee Woo Hyoung , Harmon Stephen M. , Pressman Jonathan G. , Wahman David G. 
Published: June 2024

AbstractDuctile iron and copper coupons were aged 137–189 days and 2 days, respectively, with 2 mg Cl2 L−1 monochloramine under four water chemistries (pH 7 or 9 and 0 or 3 mg L−1 orthophosphate). Subsequently, microelectrode profiles of monochloramine concentration, oxygen concentration, and pH were measured from the bulk water to near the coupon reactive surface, allowing estimation of flux and apparent surface reaction rate constants for monochloramine and oxygen. Both metals showed similar trends with orthophosphate where orthophosphate decreased metal reactivity with monochloramine (pH 9) and oxygen (pH 7). Comparing iron and copper coupons, apparent surface reaction rate constants for monochloramine and oxygen were one and two orders of magnitude greater, respectively, for iron coupons under all conditions. Overall, this research provides the first insights into monochloramine concentration, oxygen concentration, and pH by direct measurement near ductile iron and copper reactive surfaces aged in the presence of monochloramine.
The exploitation of girls in care: An ongoing struggle for recognition
Authors: Shaw Julie , Staines Jo , Fitzpatrick Claire , Hunter Katie 
Published: June 2024

AbstractDrawing upon original research data, the core task of this article is to explore some of the difficulties experienced by girls in care in England in having their exploitation recognised, along with the challenges faced by professionals from social care and criminal justice agencies in meeting their safeguarding needs. The article provides a unique insight into the ways in which the perceptions and experiences of the two groups compare with the other, as both attempts to negotiate their own set of challenges within the confines of an inadequate and under‐resourced system. It considers the sense of disconnect between the needs, expectations and perceptions of care‐experienced girls and the care they ultimately receive, emphasising how experiences of stigma intersect with gendered and racialised judgements, creating a situation where they are viewed as less than ‘ideal’ victims.
Effects of online customer reviews on sustainable clothing purchase intentions: The mediating role of perceived diagnosticity
Authors: Huang Chaohua , Chen Changhua , Wang Haijun 
Published: June 2024

AbstractOnline customer reviews play a vital role in evaluating product or service performance and serve as an important reference for other customers' purchase decisions. This study explores the influence of online customer reviews on sustainable clothing purchase intention through text mining and survey‐based methodologies. The results showed that online customer reviews focused on four dimensions: material ecology, clothing fashion, clothing functionality, and price reasonableness. Online customer reviews have a positive impact on consumers' sustainable purchase intentions, and perceived diagnosticity mediates the relationship between online customer reviews and purchase intentions. In addition, customers' prior sustainability knowledge moderates the relationship between material ecology, price reasonableness, and perceived diagnosticity. This study further enriches theoretical research on sustainable consumption within the context of online apparel retailing and helps sustainable apparel brands more accurately grasp the influencing variables of customers' sustainable consumption behaviours and formulate precise electronic word‐of‐mouth marketing strategies.
PLEK2 activates the PI3K/AKT signaling pathway to drive lung adenocarcinoma progression by upregulating SPC25
Authors: Zhang Wenqian , Yu Lei , Xu Cong , Tang Tian , Cao Jianguang , Chen Lei , Pang Xinya , Ren Weihao 
Published: June 2024

AbstractLung adenocarcinoma (LUAD) is the most common subtype of NSCLC, characterized by poor prognosis and frequently diagnosed at advanced. While previous studies have demonstrated pleckstrin‐2 (PLEK2) as aberrantly expressed and implicated in tumorigenesis across various tumor types, including LUAD, the molecular mechanisms underlying PLEK2‐mediated LUAD progression remain incompletely understood. In this study, we obtained data from The Cancer Genome Atlas (TCGA) database to assess PLEK2 expression in LUAD, a finding further confirmed through analysis of human tissue specimens. PLEK2‐silenced LUAD cellular models were subsequently constructed to examine the functional role of PLEK2 both in vitro and in vivo. Our results showed elevated PLEK2 expression in LUAD, correlating with poor patients' prognosis. PLEK2 knockdown led to a significant suppression of LUAD cell proliferation and migration, accompanied by enhanced apoptosis. Moreover, tumor growth in mice injected with PLEK2‐silencing LUAD cells was impaired. Gene expression profiling and Co‐IP assays suggested direct interaction between PLEK2 and SPC25, with downregulation of SPC25 similarly impairing cell proliferation and migration. Additionally, we revealed phosphoinositide 3‐kinase (PI3K)/AKT signaling activation as requisite for PLEK2‐induced malignant phenotypes in LUAD. Collectively, our findings underscore PLEK2's oncogenic potential in LUAD, suggesting its utility as a prognostic indicator and therapeutic target for LUAD management.
Comparative characterisation of an ecto‐5′‐nucleotidase (CD73) in non‐tumoral MCF10‐A breast cells and triple‐negative MDA‐MB‐231 breast cancer cells
Authors: Rocha‐Vieira Thais Cristino , Lacerda‐Abreu Marco Antonio , Carvalho‐Kelly Luiz Fernando , Santos‐Araújo Samara , Gondim Katia C. , Meyer‐Fernandes José Roberto 
Published: June 2024

AbstractEcto‐5′‐nucleotidase (CD73) hydrolyses 5′AMP to adenosine and inorganic phosphate. Breast cancer cells (MDA‐MB‐231) express high CD73 levels, and this enzyme has been found to play a tumour‐promoting role in breast cancer. However, no studies have sought to investigate whether CD73 has differential affinity or substrate preferences between noncancerous and cancerous breast cells. In the present study, we aimed to biochemically characterise ecto‐5′‐nucleotidase in breast cancer cell lines and assess whether its catalytic function and tumour progression are correlated in breast cancer cells. The results showed that compared to nontumoral breast MCF‐10A cells, triple‐negative breast cancer MDA‐MB‐231 cells had a higher ecto‐5′‐nucleotidase expression level and enzymatic activity. Although ecto‐5′‐nucleotidase activity in the MDA‐MB‐231 cell line showed no selectivity among monophosphorylated substrates, 5′AMP was preferred by the MCF‐10A cell line. Compared to the MCF‐10A cell line, the MDA‐MB‐231 cell line has better hydrolytic ability, lower substrate affinity, and high inhibitory potential after treatment with a specific CD73 inhibitor α,β‑methylene ADP (APCP). Therefore, we demonstrated that a specific inhibitor of the ecto‐5‐nucleotidase significantly reduced the migratory and invasive capacity of MDA‐MB‐231 cells, suggesting that ecto‐5‐nucleotidase activity might play an important role in metastatic progression.
Multicomponent Synthesis of 3(2H)‐Furanones Initiated by Copper(II)‐Catalyzed Alkyne‐Carbonyl Cross Metathesis
Authors: Su Zhenjie , Wang Shaozhong 
Published: June 2024

AbstractThe cooperative Lewis and Brønsted acid catalysis makes convergent synthesis of 3(2H)‐furanones through a three‐component coupling of 1,3‐diynes, alkyl glyoxylates and water. Control experiments support that Lewis acid‐catalyzed highly chemo‐, regio‐ and stereoselective alkyne‐carbonyl metathesis of 1,3‐diynes and alkyl glyoxylates might be the initial step of this multicomponent annulation. Further chemo‐ and regioselective hydration of the alkyne‐carbonyl metathesis product and subsequent oxa‐Michael addition promoted by Brønsted acid results in the formation of two C−O bonds of the five‐membered oxygen heterocycle.
Glyco‐DNA: Enzymatic Synthesis of Base‐Modified and Hypermodified DNA Displaying up to Four Different Monosaccharide Units in the Major Groove
Authors: Krömer Matouš , Poštová Slavětínská Lenka , Hocek Michal 
Published: June 2024

AbstractA portfolio of six modified 2′‐deoxyribonucleoside triphosphate (dNTP) derivatives derived from 5‐substituted pyrimidine or 7‐substituted 7‐deazapurine bearing different carbohydrate units (d‐glucose, d‐galactose, d‐mannose, l‐fucose, sialic acid and N−Ac‐d‐galactosamine) tethered through propargyl‐glycoside linker was designed and synthesized via the Sonogashira reactions of halogenated dNTPs with the corresponding propargyl‐glycosides. The nucleotides were found to be good substrates for DNA polymerases in enzymatic primer extension and PCR synthesis of modified and hypermodified DNA displaying up to four different sugars. Proof of concept binding study of sugar‐modified oligonucleotides with concanavalin A showed positive effect of avidity and sugar units count.
Role of manufacturers' market‐related capabilities in developing market‐oriented codevelopment and competitive advantages in an emerging market
Authors: Liu Feng‐Hsu , Tsou Hung‐Tai 
Published: June 2024

AbstractThis study investigates how a manufacturing supplier's market‐related capabilities (marketing and market‐linking capabilities) affect market‐oriented codevelopment (buyer oriented and competitor oriented) and, in turn, its competitive advantage. A manufacturing supplier with high levels of marketing and market‐linking capabilities has positive effects on buyer‐oriented codevelopment; however, only high levels of marketing capabilities lead to competitor‐oriented codevelopment with local partners. In addition, both types of market‐oriented codevelopment have positive effects on manufacturing suppliers' competitive advantage, namely, innovation, location and internalization. The central theme of this paper is that applied knowledge and collaboration in local markets based on market‐related capabilities are key characteristics that enable manufacturing suppliers to compete both locally and globally.