bluuebunny/crossref_metadata_2025_split huggingface dataset:
A trusted mechanism against device reputation attacks in Web‐of‐Things applications
Authors: Rathee Geetanjali , Kerrache Chaker Abdelaziz , Calafate Carlos T. , Song Houbing 
Published: June 2024

AbstractThe Web‐of‐Things (WoT) seeks to simplify IoT management by providing an interface for controlling and monitoring the devices. To this end, it can provide several web‐based applications focused on home automation, smart cities, smart agriculture and so forth. In particular, preventing device reputation attacks, which is one of the most significant threats to the WoT, is critical when considering the huge amount of information that is generated, processed and analyzed by the network. There may be situations where intruders deploy fake devices to introduce false information, downgrading the information from valid devices for their own benefits. Different authors have proposed various security methods and algorithms using machine learning, cryptographic or semantics‐based methods. However, the existing mechanisms have various limitations in terms of accuracy, storage overhead, and computational/communication overheads, that still need to be addressed. The trusted mechanism can be considered as another way of ensuring security while transmitting the information through the Internet by identifying their legitimacy. Hence, the aim of this article is to propose a secure and trusted WoT framework using similarity index and community of interest similarity score schemes. The proposed mechanism is evaluated against existing schemes that consider both cryptographic and semantic parameters to ensure the security in the network by using metrics such as recommendations, decay time factor, and packet loss recovery rate.
Visko‐hypoplastisches Materialmodell für tertiäre Böden in Frankfurt am Main
Authors: Ganal Aljoscha , Reul Oliver , Tafili Merita 
Published: June 2024

AbstractDie Baugrundsituation im Innenstadtbereich von Frankfurt am Main ist durch überkonsolidierte Tone und Tonmergel des Tertiärs gekennzeichnet, in die Kalksteinbänke und Sandlagen eingeschaltet sind, deren Mächtigkeit standortabhängig starken Schwankungen unterliegt. In einem Forschungsvorhaben wurde das zeitabhängige Materialverhalten dieser tertiären Tone, die die Verformungen von Bauwerken maßgeblich prägen, in einem umfassenden Laborversuchsprogramm untersucht und ein Parametersatz für das visko‐hypoplastische AVISA‐Modell bestimmt. In diesem Beitrag werden die dabei für die tertiären Frankfurter Tone gewonnenen Erkenntnisse zusammengefasst. Zudem wird ein Konzept vorgeschlagen, mit dem die Systemdurchlässigkeit und die Systemsteifigkeit der heterogenen tertiären Schichten unter Berücksichtigung eingelagerter Kalksteinbänke und Sandlagen realitätsnah in 3D‐gekoppelten Strömungs‐Verformungs‐Berechnungen mit der Finite‐Elemente‐Methode abgebildet werden kann.
Effect of ergonomic aspects on single‐ and multiproduct assembly‐line balancing problems
Authors: Giridhar Mena Puthiyaveedu , Panicker Vinay V. 
Published: June 2024

AbstractIncorporating ergonomic considerations into an assembly‐line balancing problem (ALBP) enhances productivity and minimizes ergonomic concerns. The assembly process, characterized by repetitive motions and handling numerous components, can lead to worker overload. Consequently, the inclusion of ergonomic aspects results in an appropriate distribution of assembly operations and relative workloads. This study investigates a multi‐objective ALBP aimed at minimizing the number of workstations, overall skill level required, and variance in workers' energy expenditure across workstations. To address the ALBP while considering the ergonomic aspects, this study proposes an approach based on the non‐dominated sorting genetic algorithm II (NSGA‐II) and multi‐objective simulated annealing (MOSA) using Pareto optimality. A comparative analysis of the NSGA‐II and MOSA is conducted in single‐ and multiproduct production scenarios, and a computational study involving various factors is performed to identify the dominant algorithm. The computational analysis indicates that the runtime performance of MOSA is 73.287% better than that of NSGA‐II; therefore, MOSA outperforms NSGA‐II. This study aims at applying scientific knowledge concerning manufacturing ergonomics to assist manufacturing industries in enhancing their productivity.
Single‐cell transcriptomics reveals antigen‐presenting capacity and therapeutic resistance potential of immunomodulatory endothelial cells in colorectal cancer
Authors: Wen Jingyi 
Published: June 2024

AbstractBackgroundThe heterogeneity of tumor endothelial cells (TECs) hinders the efficacy of antiangiogenic therapies (AATs). Only a small percentage of angiogenic TECs are considered effective targets for AATs. Immunomodulatory ECs (IMECs), as a newly focused functional subgroup of endothelial cells (ECs), are being evaluated for their ability to regulate tumor immune balance and influence existing AATs.MethodsBased on single‐cell transcriptome data from colorectal cancer in a publicly available database, we conducted a wide array of bioinformatic approaches to study EC subsets that meet the IMECs definition. Our investigation encompassed the gene expression signatures of these subsets, cellular composition differences, cell–cell interactions.ResultsTwo subsets that meet the IMECs definition were found in tumors and para‐cancerous tissues. Combined with the results of gene ontological analysis and interaction with CD4+ T cells, we found that IMECs can present MHC‐II antigens to mature CD4+ T cells. There were differences in the level of interaction between IMECs and different types of mature CD4+ T cell subsets. In addition, IMEC subsets had different expression levels of angiogenesis related genes. The angiogenesis score of IMECs decreased after patients received immunotherapy. IMEC subsets do not depend on a single proangiogenic receptor and are involved in regulating angiogenesis, which may reduce the efficacy of AATs. The adverse effects of specific IMEC subsets on AATs were validated in the RNA‐seq dataset of the bevacizumab treatment group.ConclusionOur study suggests the potential MHC‐II antigen presentation capacity of IMECs and the enhanced angiogenesis characteristics within tumors. The function of IMECs in the vascular network may have a potentially adverse effect on AATs. Controlling the functional properties of IMECs may be a new angle for tumor therapy.
Randomized effectiveness‐implementation trial of dialectical behavior therapy interventions for young people with borderline personality disorder symptoms
Authors: de Andrade Dominique , Davidson Lily , Robertson Carlie , Williams Philip , Leung Janni , Walter Zoe , Allan Julaine , Hides Leanne 
Published: June 2024

AbstractObjectivesDialectical behavior therapy (DBT) is an evidence‐based treatment for people with emerging borderline personality disorder (BPD). In “real world” clinical settings, standard DBT is resource intensive. Emerging evidence suggests that group‐based DBT skills training alone can lead to promising outcomes. This hybrid type 1 effectiveness‐implementation trial directly compared the effectiveness of an 8‐week group DBT‐skills training program and a 16‐week DBT‐informed program including individual treatment and group‐based skills training.MethodsThis pragmatic trial employed a staggered, parallel‐groups design. We recruited 104 participants, aged 16–25 years, with emotion dysregulation or emerging BPD symptoms. Participants were randomized to receive either program at a youth mental health service located in the Gold Coast, Australia. Data was collected via online surveys at baseline, 8‐week, 16‐week, and 24‐week follow‐up. Mixed effect linear models compared groups on the primary outcomes of emotion dysregulation and BPD symptoms, and secondary outcomes of suicidal ideation, coping skills, depression, anxiety, and stress.ResultsAcross groups there were significant and sustained improvements relating to emotion dysregulation, BPD symptoms, stress, depression, and emotion‐focused coping; but not suicide risk, anxiety, or task‐focused coping. There was no significant time by group differences between the 8‐week and 16‐week interventions on any primary or secondary outcome.ConclusionThe more intensive mode of delivering DBT was not more effective than the brief group‐based skills training. Both interventions resulted in significant improvements across both primary and most secondary outcomes. These results have implications for clinical practice regarding length and intensity of DBT treatment in young people.
N‐Acetyl cysteine‐loaded liposomes to reduce iron overload‐induced toxicity in human kidney cells
Authors: Lee Doohee , Bae Chaewon , Ryu Suhyun , Lee Kangwon 
Published: June 2024

AbstractBACKGROUNDIron overload in the body generates free radicals through the Fenton reaction, leading to adverse effects on various organs. Several antioxidants have been recommended to treat iron‐related diseases effectively. N‐Acetyl cysteine (NAC), a potent antioxidant, was investigated in this study for its potential to mitigate iron overload‐induced cell death. A liposomal formulation was developed to encapsulate NAC, employing the reverse phase evaporation method, to enhance its delivery and effectiveness. The liposomal NAC was characterized by evaluating its size, zeta potential, morphology and release profiles.RESULTSThe protective effect of liposomal NAC against iron overload‐induced toxicity was assessed in human kidney 2 (HK‐2) cells. Cell viability assays (Cell Counting Kit 8) and reactive oxygen species assays (DCFDA assay) confirmed the effectiveness of liposomal NAC in inhibiting ferroptosis induced by slow iron uptake (1 mmol L−1 ferric ammonium citrate). Additionally, liposomal NAC protected cells from toxicity resulting from rapid iron uptake (50 μmol L−1 ferric ammonium citrate, 20 μmol L−1 8‐hydroxyquinoline). The liposomal formulation demonstrated an enhanced protective effect compared to free NAC.CONCLUSIONThese findings suggest that liposomal NAC more effectively protects human kidney cells from toxicity caused by different iron uptake models than free NAC, highlighting its potential as a superior treatment option for iron overload‐induced cellular damage. © 2024 The Author(s). Journal of Chemical Technology and Biotechnology published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry (SCI).
Spatiotemporal dynamic of rice production and its carbon footprint in Hainan, China: Implications for food security and environmental sustainability
Authors: Wen Shu , Yao Wei , Tian Butao , Xu Ling , Liu Qi , Xu Yi , Qi Zhiqiang , Yang Yadong , Zeng Zhaohai , Zang Huadong 
Published: June 2024

AbstractRice (Oryza sativa L.) feeds more than half of the global population and faces the critical issues related to food security and environmental sustainability. This study analyzed double rice production data from 2010 to 2020 to assess its spatiotemporal dynamic in food production and carbon (C) footprint in Hainan province, China. The results revealed a 29.5% reduction in rice planting area, leading to a significantly decreased rice self‐sufficiency rate from 38% to 33% from 2010 to 2020. During this period, the carbon footprint per unit area (CFa) for early, late, and double rice showed a fluctuating upward trend ranging from 8.1 to 8.4, 8.9 to 9.2, and 17.0 to 17.4 t CO2‐eq ha−1, respectively. The total greenhouse gas (GHG) emissions of rice production decreased to around 2 million t CO2‐eq, primarily due to reduced planting area. The C sequestration initially increased before decreasing to 1.2 million t C in 2020 at a temporal scale. Spatially, the northeast and southwest regions exhibited ∼70% of the total GHG emissions and ∼80% of C sequestration. The regional C footprint per unit yield displayed less favorable outcomes, with some areas (e.g., Wenchang and Haikou) experiencing emission hotspots in recent years. Higher yield and smaller CFa for Lingao and Tunchang were observed compared to the average between 2010 and 2020. This study provides insights into the spatiotemporal dynamics of double rice production and GHG emissions in Hainan, offering a scientific reference for regional food security and environmental sustainability.
Clinical value of the Systemic Inflammatory Response Index for predicting acute pancreatitis severity in Vietnamese setting
Authors: Dao Yen H T , Huynh Tien M , Tran Duy T , Ho Phat T , Vo Thong D 
Published: June 2024

AbstractBackground and AimAccurate prediction of severe acute pancreatitis (SAP) is crucial for timely intervention. This study focuses on the Systemic Inflammatory Response Index (SIRI) to assess its clinical value in predicting the severity of AP in the Vietnamese context.MethodsA cross‐sectional prospective study was conducted with acute pancreatitis patients at a national hospital in Ho Chi Minh City. The patients were classified into nonsevere and severe groups, and the clinical characteristics were analyzed. The predictive abilities of SIRI, calculated using neutrophil × monocyte/lymphocyte, was assessed for predictive abilities. Multivariate regression and receiver operating characteristics (ROC) curves evaluated the prognostic factors and predictive accuracy.ResultsAmong 207 patients, 78.7% had nonsevere AP, and 21.3% had SAP. The severe group exhibited a significantly higher median SIRI (12.0) than the nonsevere group (4.9) (P < 0.001). Multivariate regression identified SIRI (odds ratio [OR] = 1.623) as an independent predictor of SAP. The ROC curve determined a SIRI cutoff of 7.82 with an area under the curve (AUC) of 0.737. Combining the SIRI and Bedside Index for Severity in Acute Pancreatitis (BISAP) score improved the predictive ability (AUC = 0.820) with increased sensitivity (90.91%) (P < 0.001).ConclusionSIRI, particularly when combined with the BISAP score, shows significant potential to predict SAP severity in the Vietnamese clinical setting, providing valuable information for effective patient management.
Nutritional attributes and microbial metagenomic profile during solid‐state fermentation of soybean meal inoculated with Lactobacillus acidophilus under non‐sterile conditions
Authors: Pérez–Velasco Ricardo , Gómez‐Gil Bruno , Martínez‐Montaño Emmanuel , González‐Córdova Aarón Fernando , Hernández Crisantema 
Published: June 2024

AbstractBACKGROUNDSoybean meal (SBM) is used widely in animal feed but it contains anti‐nutritional factors (ANFs) such as protease inhibitors – immunogenic proteins that limit its utilization. Fermentative processes could help to reduce these ANFs. The aim of this study was to evaluate the nutritional attributes, bacterial community dynamics, and microbial metagenomic profile during the solid‐state fermentation of SBM using a strain of the bacterium Lactobacillus acidophilus with or without pre‐autoclaving treatment.RESULTSFollowing fermentation, there was a reduction in the pH and a concurrent increase in the population of lactic acid bacteria. Fermentation also resulted in an increase in both crude and soluble protein levels. Trypsin inhibitor levels decreased after fermentation, particularly in fermented SBM that had not been pre‐autoclaved, with an inactivation rate higher than 90%. Moreover, high‐molecular‐weight peptides (44–158 kDa), specifically some polypeptides from the soybean immunogen glycinin and β‐conglycinin, underwent degradation during the fermentation process. Bacterial community analysis revealed the dominance of the Lactobacillus genus in all samples, regardless of the treatments applied. Metagenomic profiling identified L. acidophilus as the dominant species in inoculated SBM, irrespective of whether pre‐autoclaving was conducted or not.CONCLUSIONThis study demonstrates the feasibility of solid‐state fermentation with L. acidophilus under non‐sterile conditions to inactivate trypsin inhibitor and increase protein concentration and hydrolysate immunogen proteins into low‐molecular‐weight peptides in SBM. Lactobacillus acidophilus inoculum also inhibited the growth of undesirable bacteria. This knowledge contributes to our understanding of the potential applications of solid‐state fermentation with L. acidophilus in improving the nutritional quality of SBM. © 2024 Society of Chemical Industry.
Reorganization of Poly(Butylene Succinate) Containing Crystals of Low Stability
Authors: Jariyavidyanont Katalee , Schick Christoph , Androsch René 
Published: June 2024

AbstractPoly(butylene succinate) (PBS) forms small and imperfect crystals of low melting temperature at high supercooling of the melt. Slow heating allows reorganization of the obtained semicrystalline structure with the changes of the crystallinity and of the size and perfection of crystals analyzed by differential scanning calorimetry (DSC) and temperature‐resolved X‐ray scattering techniques. Crystals generated at 20 °C begin to melt and reorganize at a few K higher temperature with their initial imperfection and thickness unchanged upon heating to 70–80 °C. Slow heating to temperatures higher than 70–80 °C yields a distinct exothermic peak in the DSC scan, paralleled by detection of crystals of larger size/higher perfection, beginning to melt at ≈100 °C. These observations suggest that below 70–80 °C, reorganization of the semicrystalline morphology is constrained such that only minor and local improvement of the structure of crystals are possible. The formation of both perfect and thicker crystal lamellae at higher temperature proceeds via melting of imperfect crystals followed by melt‐recrystallization as for PBS solid‐state thickening is impossible. The study shows the limit of low‐temperature reorganization processes when not involving both complete melting of crystals and rearrangement of the lamellar‐stack structure.
Improved Mobility–Stretchability Properties of Diketopyrrolopyrrole‐Based Conjugated Polymers with Diastereomeric Conjugation Break Spacers
Authors: Chen Pin‐Hong , Shimizu Hiroya , Matsuda Megumi , Higashihara Tomoya , Lin Yan‐Cheng 
Published: June 2024

AbstractStretchable conjugated polymers with conjugation break spacers (CBSs) synthesized via random terpolymerization have gained considerable attention because of their efficacy in modulating mobility and stretchability. This study incorporates a series of dianhydrohexitol diastereomers of isosorbide (ISB) and isomannide (IMN) units into the diketopyrrolopyrrole‐based backbone as CBSs. It is found that the distorted CBS (IMN) improves the mobility–stretchability properties of the polymer with a highly coplanar backbone, whereas the extended CBS (ISB) enhances those of the polymer with a noncoplanar backbone. Additionally, the different configurations of ISB and IMN sufficiently affect the solid‐state packing, aggregation capabilities, crystallographic parameters, and mobility–stretchability properties of the polymer. The IMN‐based polymers exhibit the highest mobility of 1.69 cm2 V−1 s−1 and crystallinity retentions of (85.7, 78.6)% under 20% and 60% strains, outperforming their ISB‐based or unmodified counterparts. The improvement is correlated with a robust aggregation capability. Furthermore, the CBS content affects aggregation behavior, notably affecting mobility. This result indicates that incorporating CBSs into the polymer can enhance backbone flexibility via movement and rotation of the CBS without affecting the crystalline regions.
Optimization and validation of a virus‐like particle pseudotyped virus neutralization assay for SARS‐CoV‐2
Authors: Liu Shuo , Zhang Li , Fu Wangjun , Liang Ziteng , Yu Yuanling , Li Tao , Tong Jincheng , Liu Fan , Nie Jianhui , Lu Qiong , Lu Shuaiyao , Huang Weijin , Wang Youchun 
Published: June 2024

AbstractSpike‐protein‐based pseudotyped viruses were used to evaluate vaccines during the COVID‐19 pandemic. However, they cannot be used to evaluate the envelope (E), membrane (M), and nucleocapsid (N) proteins. The first generation of virus‐like particle (VLP) pseudotyped viruses contains these four structural proteins, but their titers for wild‐type severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) are relatively low, even lower for the omicron variant, rendering them unsuitable for neutralizing antibody detection. By optimizing the spike glycoprotein signal peptide, substituting the complexed M and E proteins with SARS‐COV‐1, optimizing the N protein with specific mutations (P199L, S202R, and R203M), and truncating the packaging signal, PS9, we increased the titer of the wild‐type VLP pseudotyped virus over 100‐fold, and successfully packaged the omicron VLP pseudotyped virus. The SARS‐CoV‐2 VLP pseudotyped viruses maintained stable titers, even through 10 freeze–thaw cycles. The key neutralization assay parameters were optimized, including cell type, cell number, and viral inoculum. The assay demonstrated minimal variation in both intra‐ and interassay results, at 11.5% and 11.1%, respectively. The correlation between the VLP pseudotyped virus and the authentic virus was strong (r = 0.9). Suitable for high‐throughput detection of various mutant strains in clinical serum. In summary, we have developed a reliable neutralization assay for SARS‐CoV‐2 based on VLP pseudotyped virus.
Financial services in China: Why not choose joint‐stock commercial banks?
Authors: You Shanshan , Li Jialong 
Published: June 2024

AbstractThis paper examines the influence of households' choice of banks on financial service usage in China. Our results show that choosing joint‐stock commercial banks could significantly increase household usage of financial services. Moreover, the positive effect of choosing joint‐stock commercial banks on household usage of financial services is more pronounced for rural and high‐income households. In addition, we find that the financial literacy and risk tolerance of the household head can expand the positive effect of choosing joint‐stock commercial banks on household financial service usage.
An SPH framework for drained and undrained loading over large deformations
Authors: del Castillo Enrique M. , Fávero Neto Alomir H. , Geng Jun , Borja Ronaldo I. 
Published: June 2024

AbstractWe propose a new approach for performing drained and undrained loading of elastoplastic geomaterials over large deformations using smoothed particle hydrodynamics (SPH), a meshfree continuum particle method, combined with the modified Cam Clay (MCC) model of critical state soil mechanics. The numerical approach draws upon a novel one‐particle two‐phase penalty‐method based formulation for handling undrained loading in saturated soils, which allows tracking of the buildup of pore‐water pressures under combined shearing and compression. Large‐scale parallelized simulations are employed to accommodate a significant number of degrees of freedom in a three‐dimensional setting. After verification and benchmark testing, the SPH based formulation is used to analyze the propagation of reverse faults through fluid‐saturated clay deposits and the rupture of strike‐slip faults across earthen embankments. The computational methodology tests the robustness of the meshfree approach in situations where the soil tends to dilate on the ‘dry’ side of the critical state line and to compact on the ‘wet’ side, but cannot, because of the incompressibility constraint imposed by undrained loading. Our results extend the current understanding of fault rupture modeling and further demonstrate the potential of our framework together with the SPH method for large deformation analyses of complex problems in geotechnics.