bluuebunny/crossref_metadata_2025_split huggingface dataset:
Driven to Distraction: Extraneous Events and Underreaction to Earnings News
Authors: HIRSHLEIFER DAVID , LIM SONYA SEONGYEON , TEOH SIEW HONG 
Published: September 2009

ABSTRACTRecent studies propose that limited investor attention causes market underreactions. This paper directly tests this explanation by measuring the information load faced by investors. The investor distraction hypothesis holds that extraneous news inhibits market reactions to relevant news. We find that the immediate price and volume reaction to a firm's earnings surprise is much weaker, and post‐announcement drift much stronger, when a greater number of same‐day earnings announcements are made by other firms. We evaluate the economic importance of distraction effects through a trading strategy, which yields substantial alphas. Industry‐unrelated news and large earnings surprises have a stronger distracting effect.
Getting Out Early: An Analysis of Market Making Activity at the Recommending Analyst's Firm
Authors: JUERGENS JENNIFER L. , LINDSEY LAURA 
Published: September 2009

ABSTRACTThis paper examines trading volume for Nasdaq market makers around analyst recommendation changes issued by an analyst at the same firm. Using Nasdaq PostData, we find a disproportionate increase in market making volume associated with the firm's recommendation changes and evidence of elevated sell volume at the recommending analyst's firm in the 2 days preceding a downgrade. The implications are that the information source matters in determining the placement of trades and that the issuing analyst's firm appears to be rewarded for prereleasing information through increased volume. These findings constitute new evidence of compensation for research production through the market making channel.
Making Sense of Cents: An Examination of Firms That Marginally Miss or Beat Analyst Forecasts
Authors: BHOJRAJ SANJEEV , HRIBAR PAUL , PICCONI MARC , McINNIS JOHN 
Published: September 2009

ABSTRACTThis paper examines the performance consequences of cutting discretionary expenditures and managing accruals to exceed analyst forecasts. We show that firms that just beat analyst forecasts with low quality earnings exhibit a short‐term stock price benefit relative to firms that miss forecasts with high quality earnings. This trend, however, reverses over a 3‐year horizon. Additionally, firms reducing discretionary expenditures to beat forecasts have significantly greater equity issuances and insider selling in the following year, consistent with managers understanding the myopic nature of their actions. Our results confirm survey evidence suggesting managers engage in myopic behavior to beat benchmarks.
Outcomes in Patients Requiring Cardioversion Following Catheter Ablation of Atrial Fibrillation
Authors: CHILUKURI KARUNA , DUKES JONATHAN , DALAL DARSHAN , MARINE JOSEPH E. , HENRIKSON CHARLES A. , SCHERR DANIEL , SINHA SUNIL , BERGER RONALD , CHENG ALAN , NAZARIAN SAMAN , SPRAGG DAVID , CALKINS HUGH 
Published: September 2009

Outcomes of Cardioversion Post AF Ablation. Introduction: Early recurrence of atrial tachyarrhythmias is commonly noted after catheter ablation of atrial fibrillation (AF). The long‐term outcomes of patients who require cardioversion for persistent AF after AF ablation is not known. This study reports the outcomes of patients who underwent cardioversion for persistent AF or atrial flutter following an AF ablation procedure.
Methods:
The patient population comprised 55 patients (mean age 58 ± 10 years, 35% paroxysmal) who underwent catheter ablation of AF and subsequently required electrical cardioversion for persistent AF (45 patients) or atrial flutter (10 patients). Cardioversion was defined as early (within 90 days of the ablation procedure) or late (between 90 and 180 days following ablation).
Results:
The mean follow‐up duration was 15 ± 8 months. Forty‐six of the 55 patients (84%) patients experienced recurrence during follow‐up. The average time to recurrence after cardioversion was 37 days. Of the 55 patients, 8 (15%) patients had a complete success, 11 (20%) patients had a partial success and 36 patients (65%) had a failed outcome. Seven of the 43 patients (16%) who underwent early cardioversion had a complete success as opposed to one of 12 patients (8%) who underwent late cardioversion (P = 0.49).
Conclusions:
This study shows that >80% of patients who undergo cardioversion for persistent AF or atrial flutter after AF ablation have recurrence. The timing of cardioversion did not affect the outcome. These findings allow clinicians to provide realistic expectations to patients regarding the long‐term outcome and/or requirement for a second ablation procedure. (J Cardiovasc Electrophysiol, Vol. 21, pp. 27–32, January 2010)
Idiopathic Ventricular Arrhythmias Originating from the Papillary Muscles in the Left Ventricle: Prevalence, Electrocardiographic and Electrophysiological Characteristics, and Results of the Radiofrequency Catheter Ablation
Authors: YAMADA TAKUMI , DOPPALAPUDI HARISH , McELDERRY HUGH T. , OKADA TARO , MURAKAMI YOSHIMASA , INDEN YASUYA , YOSHIDA YUKIHIKO , KANEKO SHINJI , YOSHIDA NAOKI , MUROHARA TOYOAKI , EPSTEIN ANDREW E. , PLUMB VANCE J. , KAY G. NEAL 
Published: September 2009

Idiopathic VAs Originating from the LV Papillary Muscles. Introduction: Idiopathic ventricular arrhythmias (VAs) can originate from the left ventricular (LV) papillary muscles (PAMs). This study investigated the prevalence, electrocardiographic and electrophysiological characteristics, and results of catheter ablation of these VAs, and compared them with other LV VAs.
Methods and Results:
We studied 71 patients with VAs originating from the LV anterolateral and posteroseptal regions among 159 patients undergoing successful catheter ablation of idiopathic LV VAs. PAM VAs were uncommon, rare in a sustained form, and more common from the posterior papillary muscle (PPM) than anterior papillary muscle (APM). A younger age was a good predictor for differentiating left posterior fascicular VAs from PPM VAs. There were several electrocardiographic features that accurately differentiated PAM and LV fascicular VAs from mitral annular VAs. However, an R/S ratio ≤1 in lead V6 in the LV anterolateral region and a QRS duration >160 ms in the LV posteroseptal region were the only reliable predictors for differentiating PAM VAs from LV fascicular VAs. A sharp ventricular prepotential was recorded at the successful ablation site during 42% of the PAM VAs. Radiofrequency current with an irrigated or conventional 8‐mm tip ablation catheter was required to achieve a lasting ablation of the PAM VA origins whereas that with a nonirrigated 4‐mm tip ablation catheter produced excellent results in LV fascicular and mitral annular VAs.
Conclusions:
There are differences in the electrocardiographic and electrophysiological features among VAs originating from these regions that are helpful for their diagnosis and effective catheter ablation. (J Cardiovasc Electrophysiol, Vol. 21, pp. 62–69, January 2010)
Neurally Mediated Syncope as a Cause of Syncope in Patients with Brugada Electrocardiogram
Authors: YOKOKAWA MIKI , OKAMURA HIDEO , NODA TAKASHI , SATOMI KAZUHIRO , SUYAMA KAZUHIRO , KURITA TAKASHI , AIHARA NAOHIKO , KAMAKURA SHIRO , SHIMIZU WATARU 
Published: September 2009

Neurally Mediated Syncope in Brugada Syndrome.

Introduction:
Patients with type 1 Brugada electrocardiogram (ECG) and an episode of syncope are diagnosed as symptomatic Brugada syndrome; however, all episodes of syncope may not be due to ventricular tachyarrhythmia.
Methods and Results:
Forty‐six patients with type 1 Brugada ECG (all males, 51 ± 13 years, 29 spontaneous, 17 Ic‐drug induced), 20 healthy control subjects (all males, 35 ± 11 years), and 15 patients with suspected neurally mediated syncope (NMS; 9 males, 54 ± 22 years) underwent the head‐up tilt (HUT) test. During the HUT test, 12‐lead ECGs were recorded in all patients, and the heart rate variability was investigated in some patients. Sixteen (35%) of 46 patients with Brugada ECG, 2 (10%) of 20 control subjects, and 10 (67%) of 15 patients with suspected NMS showed positive responses to the HUT test. Although no significant differences were observed in HUT‐positive rate among Brugada patients with documented VT (7/14; 50%), syncope (5/19; 26%) and asymptomatic patients (4/13; 31%), the HUT‐positive rate was significantly higher in patients with documented VT (50%) and those with VT or no symptoms (11/27, 41%) compared to that in control subjects (10%) (P < 0.05). Augmentation of ST‐segment amplitude (≥0.05 mV) in leads V1‐V3 was observed in 11 (69%) of 16 HUT‐positive patients with Brugada ECG during vasovagal responses, and was associated with augmentation of parasympathetic tone following sympathetic withdrawal.
Conclusion:
Thirty‐five percent of patients with Brugada ECG showed vasovagal responses during the HUT test, suggesting that some Brugada patients have impaired balance of autonomic nervous system, which may relate to their syncopal episodes. (J Cardiovasc Electrophysiol, Vol. 21, pp. 186‐192, February 2010)
Uninterrupted Warfarin for Periprocedural Anticoagulation in Catheter Ablation of Typical Atrial Flutter: A Safe and Cost‐Effective Strategy
Authors: FINLAY MALCOLM , SAWHNEY VINIT , SCHILLING RICHARD , THOMAS GLYN , DUNCAN EDWARD , HUNTER ROSS , VIRDI GURPREET , ABRAMS DOMINIC , SPORTON SIMON , DHINOJA MEHUL , EARLEY MARK 
Published: September 2009

Uninterrupted Warfarin for Periprocedural Anticoagulation in Catheter Ablation of Typical Atrial Flutter.
Introduction: Many patients undergoing catheter ablation of atrial flutter (AFL) require periprocedural anticoagulation. We compared a strategy of conversion to low molecular weight heparin (LMWH) periprocedure to uninterrupted warfarinization in a nonrandomized, case‐controlled study. Methods: One hundred and one consecutive patients requiring periprocedural anticoagulation for catheter ablation of typical AFL were studied. The first 51 patients underwent conversion to LMWH (enoxaparin 1 mg/kg bd) with a warfarin pause (LMWH group), the subsequent 50 continued with uninterrupted oral anticoagulation (Warfarin group). Primary endpoint was a composite of major and minor bleeding complications and groin symptoms. Results: Fewer patients in the Warfarin group reached the primary endpoint (36.0% vs 56.8%, P = 0.013). Four patients in the LMWH group but no patient in the Warfarin group required hospital admission for bleeding‐related complications. Cost analysis showed mean cost per patient of anticoagulation with LMWH to be £100.9 (95% CI 94.46–107.30) compared to £10.23 (4.49–15.97) in the Warfarin group (P < 0.0001). Transesophageal echocardiography (TEE) was performed prior to ablation in 11 patients in the Warfarin group and in 3 patients in the LMWH (P = 0.019). When TEE costs were included, costs were £125.00 ($188.25) (96.80–153.60) for the LMWH strategy and £108.5 ($163.40) (54.92–162.1) for the Warfarin group (P < 0.0001). Conclusions: Catheter ablation of typical AFL without interruption of warfarin appears safer and more cost‐effective than periprocedural conversion to LMWH. It could be used as a routine anticoagulation strategy for the ablation of right‐sided arrhythmias. (J Cardiovasc Electrophysiol, Vol. 21, pp. 150‐154, February 2010)
Development and use of a monoclonal antibody to detect semi‐digested proteins of the English grain aphid, Sitobion avenae, in the guts of ladybird beetle predators
Authors: Gao Shu‐jing , Zhou Xiao‐rong , Pang Bao‐ping , Van Loon Joop J.A. , Zhao Gui‐qin 
Published: September 2009

AbstractA monoclonal antibody (McAb), EGA‐4A9, was developed to detect the semi‐digested proteins of the English grain aphid, Sitobion avenae (Fabricius) (Hemiptera: Aphididae), in predatory ladybird beetles (species of the genera Adonia, Coccinella, Hippodamia, and Propylea) using the gut homogenate of Adonia variegata (Goeze) (Coleoptera: Coccinellidae) adults which had fed on S. avenae as immunogen. The McAb was selected by screening hybridoma lines for antibodies that bound with the semi‐digested aphid proteins in ladybirds. A double antibody sandwich enzyme‐linked immuno‐sorbent assay (ELISA) using ClonotypingTM System/HRP showed that it belonged to the IgG2a isotype. It did not cross‐react with any of the 21 arthropod species tested besides the ladybird beetles fed on S. avenae with an indirect ELISA. It could still detect the semi‐digested proteins in the gut of a ladybird adult, kept at 25 °C, that had ingested one aphid 6 days before. The extended antigen detection period and the high specificity of the antibody indicated that EGA‐4A9 could be used to study interactions between English grain aphids and their ladybird predators in the field. Between 28 and 72% of coccinellids collected from the field were positive for English grain aphid protein by ELISA. The percentage of McAb‐positive predatory ladybird beetles was positively correlated with the density of S. avenae in wheat fields.
Evaluation of four hematology and a chemistry portable benchtop analyzers using non‐human primate blood
Authors: Snider C.L. , Dick Jr E.J , McGlasson D.L. , Robbins M.C. , Sholund R.L. , Bommineni Y.R. , Hubbard G.B. 
Published: September 2009

AbstractBackground Near patient testing (NPT) and point‐of‐care testing (POCT) using portable benchtop analyzers has become necessary in many areas of the medical community, including biocontainment.Methods We evaluated the Beckman AcT diff, Abaxis Vetscan HMII (two instruments), Abbott Cell‐Dyn 1800, and Abaxis Vetscan VS2 for within‐run precision and correlation to central laboratory instruments using non‐human primates blood.Results Compared with the central laboratory instruments, the Beckman AcT diff correlated on 80%; the HMII instruments on 31% and 44%, the CD1800 on 31%, and the VS2 on 71% of assays. For assays with published manufacturers precision guidelines, the AcT diff met all nine, the HMII instruments met one and six of six, and the CD 1800 met one of six.Conclusions Laboratories using NPT/POCT must test their individual instruments for precision and correlation, identify assays that are reliable, and exclude or develop supplemental procedures for assays that are not.
Spontaneous gallbladder pathology in baboons
Authors: Slingluff J.L. , Williams J.T. , Blau L. , Blau A. , Dick Jr E.J , Hubbard G.B. 
Published: September 2009

AbstractBackground  Gallbladder pathology (GBP) is a relatively uncommon, naturally occurring morbidity in both baboons and humans.Methods  A retrospective analysis was performed on 7776 necropsy reports over a 20 year period to determine the prevalence of baboon GBP.Results  Ninety‐seven cases of GBP were identified, yielding a 20 year population prevalence of 1.25%. GBP is more common in adult female baboons, occurring with a female to male ratio of nearly 2:1. Among gallbladder pathologies, cholecystitis (35.1%) and cholelithiasis (29.9%) were the most prevalent abnormalities, followed by hyperplasia (16.5%), edema (15.5%), amyloidosis (5.2%), fibrosis (4.1%), necrosis (4.1%), and hemorrhage (1.0%).Conclusion  Many epidemiologic similarities exist between GBP in baboons and humans suggesting that the baboon may serve as a reliable animal model system for investigating GBP in humans.
Regulation of Insulin Secretion by Phosphatidylinositol‐4,5‐Bisphosphate
Authors: Tomas Alejandra , Yermen Barbara , Regazzi Romano , Pessin Jeffrey E. , Halban Philippe A. 
Published: September 2009

Abstract The role of PIP2 in pancreatic beta cell function was examined here using the beta cell line MIN6B1. Blocking PIP2 with PH‐PLC‐GFP or PIP5KIγ RNAi did not impact on glucose‐stimulated secretion although susceptibility to apoptosis was increased. Over‐expression of PIP5KIγ improved cell survival and inhibited secretion with accumulation of endocytic vacuoles containing F‐actin, PIP2, transferrin receptor, caveolin 1, Arf6 and the insulin granule membrane protein phogrin but not insulin. Expression of constitutively active Arf6 Q67L also resulted in vacuole formation and inhibition of secretion, which was reversed by PH‐PLC‐GFP co‐expression. PIP2 co‐localized with gelsolin and F‐actin, and gelsolin co‐expression partially reversed the secretory defect of PIP5KIγ‐over‐expressing cells. RhoA/ROCK inhibition increased actin depolymerization and secretion, which was prevented by over‐expressing PIP5KIγ, while blocking PIP2 reduced constitutively active RhoA V14‐induced F‐actin polymerization. In conclusion, although PIP2 plays a pro‐survival role in MIN6B1 cells, excessive PIP2 production because of PIP5KIγ over‐expression inhibits secretion because of both a defective Arf6/PIP5KIγ‐dependent endocytic recycling of secretory membrane and secretory membrane components such as phogrin and the RhoA/ROCK/PIP5KIγ‐dependent perturbation of F‐actin cytoskeleton remodelling.
Magnetic Resonance Imaging of Pulmonary Diseases
Authors: Ley‐Zaporozhan J. , Kauczor H‐U. , Ley S. 
Published: September 2009

SummaryMagnetic Resonance Imaging (MRI) of the chest and especially the lung is more and more accepted as a valuable additional imaging modality for several pulmonary diseases. Magnetic Resonance Imaging allows for combined morphological and functional imaging and therefore elucidates perfectly the effect of parenchymal changes and destruction onto pulmonary perfusion and ventilation. This overview presents the current status for the application of pulmonary MRI in chronic obstructive pulmonary disease as well as infectious and neoplastic diseases.
Utility of hematologic and volume, conductivity, and scatter parameters from umbilical cord blood in predicting chorioamnionitis
Authors: LEE J. C. , AHERN T. P. , CHAVES F. P. , QUILLEN K. 
Published: September 2009

SummaryWe evaluated the utility of routine hematologic parameters and volume, conductivity, and scatter (VCS) parameters from umbilical cord blood in predicting pathologically confirmed chorioamnionitis. Chorioamnionitis is strongly associated with early neonatal sepsis and is the major in utero source of infectious exposure. We prospectively identified mothers who had placenta submitted for pathology and subsequently identified corresponding neonate cord blood sent for routine blood typing (n = 99). Cord blood was then sent for routine complete blood count with differential (CBCD). Among the same neonates, we retrospectively identified those who had peripheral blood sent for CBCD. We collected VCS parameter data, which are used in determining an automated leukocyte differential, from our hematology analyzer. Routine hematologic as well as VCS parameters from both cord and peripheral blood were then evaluated for predicting pathologically confirmed chorioamnionitis. In the study population, the absolute neutrophil count, neutrophil differential, mean neutrophil conductivity, and neutrophil conductivity standard deviation (SD) from cord blood showed the best predictive ability for chorioamnionitis. Among neonates with intrapartum antibiotic prophylaxis exposure, the band differential, immature neutrophil precursor differential, and neutrophil conductivity SD showed the best predictive ability. Lastly, among the neonates who had peripheral blood CBCD, the band differential and immature neutrophil precursor differential showed the best predictive ability. Overall, the peripheral blood band differential and immature neutrophil precursor differential showed better specificity and positive predictive value for chorioamnionitis than the cord blood parameters. However, the cord blood absolute neutrophil count, neutrophil differential, and mean neutrophil conductivity showed better negative predictive value. Cord blood can be a valuable source of diagnostic laboratory testing for neonates because of their small blood volume. This is the first study demonstrating that routine hematologic and VCS parameters from cord blood can be used to predict pathologically confirmed chorioamnionitis.
Facile fingerstick insulin analysis: Application to monitoring postprandial insulin responses to snack foods
Authors: MEGDAL Peter A. , SIEMSEN Daniel , SANDS David , DRATZ Edward A. , HANDELMAN Garry J. 
Published: September 2009

AbstractBackground: Energy intake from snacks has been increasing in the American diet, but insulin and glucose responses to foods are generally reported for meal‐sized portions (800–1200 kJ). Established methods for insulin determination routinely use indwelling catheters and radioimmunoassay (RIA). The aim of the present study was to develop a more facile method, collecting fingerstick blood samples and measuring insulin with precise ELISA, and then applying this method to determine responses to snack‐sized food portions.Methods: Six healthy, fasting adult volunteers consumed seven different snack foods on separate days, containing approximately 400 kJ/portion. Insulin was measured by ELISA and glucose was measured with the hexokinase procedure in samples collected by fingerstick at 0, 30, and 60 min after consumption of the snack food.Results: A portion of doughnut (half a glazed doughnut) led to marked changes in insulin and glucose; skim milk, an apple, and oatmeal changed insulin significantly; wrinkled peas resulted in a lower glucose response than smooth peas; and walnuts led to non‐significant changes in both insulin and glucose over a 60‐min period.Conclusions: The fingerstick sampling and insulin measurement procedure is simple, economical, and more precise than established RIA. The method can be applied to children and adults to monitor insulin responses following food consumption, as well as during therapeutic assessments or intervention trials. Public health advisories regarding snacks that minimize increases in insulin are desirable for individuals trying to reduce or maintain their weight, because elevated insulin stimulates carbohydrate conversion to fat and suppresses the mobilization of stored triglycerides for energy generation.
Imaging of ovarian teratomas: Appearances and complications
Authors: Choudhary S , Fasih N , Innes M Mc , Marginean C 
Published: September 2009

SummaryOvarian teratomas are the most common germ cell neoplasm. Subtypes of teratoma include mature cystic, immature and the monodermal teratomas. The benign cystic teratoma shows typical imaging manifestations and can be complicated by torsion, rupture and uncommonly malignant degeneration. Uncommon subtypes of teratomas include the immature, which is usually malignant at diagnosis. The growing teratoma syndrome is an uncommon complication reported in patients treated for immature teratomas. The monodermal teratomas which include the struma ovarii may also have specific imaging characteristics that should be recognised on imaging. This paper aims to provide a comprehensive review describing the spectrum of imaging findings of these ovarian tumours and associated complications