bluuebunny/crossref_metadata_2025_split huggingface dataset:
How much (more) is fair to pay? The ethics of merit in assessing poverty wages in organizations
Authors: Pinto Javier , Scalzo Germán R. 
Published: June 2024

Purpose
This study aims to conduct a comprehensive analysis of poverty salaries and minimum wage in light of virtue ethics and a new natural law perspective on work.

Design/methodology/approach
Existing approaches to poverty wages are critically examined, including the nonworseness claim and legal minimalism. This paper introduces a more nuanced framework, taking into account the concepts of merit and participation in light of virtue ethics.

Findings
We argue that the fairness of minimum wage policies can be assessed as a matter of contributive-distributive justice by considering individual contributions to an organization's outcomes within an approach that provides a robust foundation for reconciling the dignity of work with the operational realities of organizations.

Research limitations/implications
Empirical research is needed to validate the practical application of the proposed conceptual framework for addressing poverty wages.

Practical implications
The paper provides better decisional arguments for employers concerned with poverty salaries in their organizations considering the moral dimensions of wage policies and employee well-being, offering guidance for potential adjustments in compensation practices. It also contributes to the discourse on social and economic justice by emphasizing the moral obligations of organizations in fostering a just and dignified work environment without the employee's participation.

Originality/value
This paper presents a novel approach that blends virtue ethics and new natural law principles, emphasizing the moral responsibilities of employers and organizations in addressing the conditions of the working poor. It also highlights the potential for a “lesser evil” situation, morally acceptable when it serves as a transitional phase aimed at improving working conditions and employee well-being.
Understanding AI innovation contexts: a review and content analysis of artificial intelligence and entrepreneurial ecosystems research
Authors: Roundy Philip T. , Asllani Arben 
Published: June 2024

PurposeAn emerging research stream focuses on the place-based ecosystems where artificial intelligence (AI) innovations emerge and develop. This literature builds on the contextual turn in management research and, specifically, work on entrepreneurial ecosystems. However, as a nascent research area, the literature on AI and entrepreneurial ecosystems is fragmented across academic and practitioner boundaries and unconnected disciplines because of disparate and ill-defined concepts. As a result, the literature is disorganized and its main insights are latent. The purpose of this paper is to synthesize research on AI ecosystems and identify the main insights.Design/methodology/approachWe first consolidate research on the “where” of AI innovation through a scoping review. To address the fragmentation in the literature and understand how entrepreneurial ecosystems are associated with AI innovation, we then use content analysis to explore the literature.FindingsWe identify the main characteristics of the AI and ecosystems literature and the key dimensions of “AI entrepreneurial ecosystems”: the local actors and factors in geographic territories that are coordinated to support the creation and development of AI technologies. We clarify the relationships among AI technologies and ecosystem dimensions and uncover the latent themes and underlying structure of research on AI entrepreneurial ecosystems.Originality/valueWe increase conceptual precision by introducing and defining an umbrella concept—AI entrepreneurial ecosystem—and propose a research agenda to spur further insights. Our analysis contributes to research at the intersection of management, information systems, and entrepreneurship and creates actionable insights for practitioners influenced by the geographic agglomeration of AI innovation.
A meta-analysis of antecedents and consequences of green trust
Authors: Chauhan Sumedha , Goyal Sandeep 
Published: June 2024

PurposeIncreasing demand for goods and services strains environmental sustainability, driving interest in green products. Trust in these products is vital for adoption. Scholars have examined factors affecting green trust, but a comprehensive framework involving cognitive and affective factors as antecedents and behavioral outcomes as consequences is lacking. This study aims to address this gap and introduces cultural and socio-demographic variables as moderators.Design/methodology/approachThe study consolidates the outcomes of 79 empirical publications on green trust and conducts a meta-analysis.FindingsAll the cognitive and affective factors and behavioral outcomes are significantly associated with green trust. The moderator analysis provides many valuable insights as it highlights the context dependency of various relationships of green trust.Research limitations/implicationsUsing an extensive literature review, this study introduces an integrated framework that clarifies the antecedents and consequences of green trust. This work enriches the existing body of knowledge by investigating the influence of cultural and socio-demographic factors as moderators on these relationships, offering significant insights into the realm of green trust.Practical implicationsThis research yields valuable guidance for providers of green products/services, shedding light on the factors that foster trust in their offerings and emphasizing the importance of customized strategies that take into account cultural and socio-demographic variables.Originality/valueThis is an original study that contributes to the green trust literature.
Advanced AI-driven image fusion techniques in lung cancer diagnostics: systematic review and meta-analysis for precisionmedicine
Authors: Sun Meiling , Cui Changlei 
Published: June 2024

PurposeThis paper aims to critically evaluate the role of advanced artificial intelligence (AI)-enhanced image fusion techniques in lung cancer diagnostics within the context of AI-driven precision medicine.Design/methodology/approachWe conducted a systematic review of various studies to assess the impact of AI-based methodologies on the accuracy and efficiency of lung cancer diagnosis. The focus was on the integration of AI in image fusion techniques and their application in personalized treatment strategies.FindingsThe review reveals significant improvements in diagnostic precision, a crucial aspect of the evolution of AI in healthcare. These AI-driven techniques substantially enhance the accuracy of lung cancer diagnosis, thereby influencing personalized treatment approaches. The study also explores the broader implications of these methodologies on healthcare resource allocation, policy formation, and epidemiological trends.Originality/valueThis study is notable for both emphasizing the clinical importance of AI-integrated image fusion in lung cancer treatment and illuminating the profound influence these technologies have in the future AI-driven healthcare systems.
Involvement of SARS‐CoV‐2 accessory proteins in immunopathogenesis
Authors: Ito Hayato , Tamura Tomokazu , Wang Lei , Mori Kento , Tsuda Masumi , Suzuki Rigel , Suzuki Saori , Yoshimatsu Kumiko , Tanaka Shinya , Fukuhara Takasuke 
Published: June 2024

AbstractSevere acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) is the largest single‐stranded RNA virus known to date. Its genome contains multiple accessory protein genes that act against host immune responses but are not required for progeny virus production. The functions of the accessory proteins in the viral life cycle have been examined, but their involvement in viral pathogenicity remains unclear. Here, we investigated the roles of the accessory proteins in viral immunopathogenicity. To this end, recombinant SARS‐CoV‐2 possessing nonsense mutations in the seven accessory protein open reading frames (ORFs) (ORF3a, ORF3b, ORF6, ORF7a, ORF8, ORF9b, and ORF10) was de novo generated using an early pandemic SARS‐CoV‐2 strain as a backbone. We confirmed that the resultant virus (termed ORF3–10 KO) did not express accessory proteins in infected cells and retained the desired mutations in the viral genome. In cell culture, the ORF3–10 KO virus exhibited similar virus growth kinetics as the parental virus. In hamsters, ORF3–10 KO virus infection resulted in mild weight loss and reduced viral replication in the oral cavity and lung tissue. ORF3–10 KO virus infection led to mild inflammation, indicating that an inability to evade innate immune sensing because of a lack of accessory proteins impairs virus growth in vivo and results in quick elimination from the body. Overall, we showed that SARS‐CoV‐2 accessory proteins are involved in immunopathogenicity.
Novel electrical therapy to improve sleep disturbance in patients with autoimmune rheumatic diseases
Authors: Zhao Jiaoshi , He Peili , Wei Qiujing , Zhou Liuzhong , Ers Suleyman Ahmed , Gu Jieruo 
Published: June 2024

AbstractObjectivesSleep disturbance is common in autoimmune rheumatism diseases (ARD) and it plays an important role in activating disease and affects the quality of life. This study aims to evaluate the efficacy and acceptability of the novel electrical therapy on sleep disturbance in ARD patients and its effect on immunologic factors.MethodsA total of 51 ARD patients (26 treatment group and 25 control group) with sleep disturbance were enrolled in this study. Sleep parameters and immunological indicators (serum level of 12 cytokines and immune function) were collected. The novel electrical therapy was prescribed for 15–30 min 3–6 times a day. The Pittsburg Sleep Index (PSQI) was assessed before and after 3 months’ treatment by Mi Energy equipment. Immune function and serum levels of cytokines of all participants at baseline and after treatment were tested with flow cytometry and flow immunofluorescence, respectively. Correlation analysis was used to analyze the relationship between sleep disturbance and immunologic factors. Multiple linear regression analysis was employed to investigate the risk of sleep disturbance in ARD.ResultsThe global score of PSQI (Baseline: 12.81 ± 4.07, After novel electrical therapy: 4.88 ± 2.76) was effectively improved after 3 months of adjuvant therapy by electrical therapy. We also found that serum levels of IL‐8 and IL‐1β statistically significantly decreased after novel electrical therapy. This adjuvant therapy can also significantly decrease the percentage of CD4 + CD8 + T cell, effector memory CD8 + T cell, Memory CD8 + T cell, Th17 cell, and plasma cell and significantly can increase the percentage of naïve CD8 + T cell, Th2 cell, and Tfh2 cell. Nevertheless, all serum level of 12 cytokines and the percentage of immune cells did not correlate with the PSQI global score except the Tc17 cell. Furthermore, age is an independent risk factor influencing PSQI scores (OR = 1.15, p < 0.05) in patients with autoimmune diseases through multiple linear regression analysis.ConclusionsNovel electrical therapy can effectively improve sleep disturbance in patients with ARD. It can also change the serum level of some cytokines (IL‐8 and IL‐1β) and percentage of immune cells (CD4 + CD8 + T cell, effector memory CD8 + T cell, Memory CD8 + T cell, Th17 cell, naïve CD8 + T cell, Th2 cell, Tfh2 cell, and plasma cell).
Real‐world effectiveness and safety of tofacitinib for alopecia areata: A retrospective cohort study of 202 patients
Authors: Cranwell William , Meah Nekma , Wall Dmitri , Bhoyrul Bevin , Laita Bokhari , Sinclair Rodney D. 
Published: June 2024

AbstractBackgroundAlopecia areata (AA) is an autoimmune hair loss disorder characterised by collapse of hair follicle immune privilege and mediated by autoreactive CD8+ T lymphocytes and natural killer cells. Treatment is often unsatisfactory. The Janus kinase‐signal transducer and activator of transcription (JAK–STAT) pathway is implicated in the pathogenesis of AA and Janus Kinase inhibitor (JAKi) medications are promising emerging treatments for AA.ObjectivesWe evaluated the safety and effectiveness of tofacitinib in a real‐world setting over 18 months of treatment.MethodsA retrospective cohort study of all patients with scalp AA commenced on tofacitinib between 1 November 2016 and 31 May 2019. The primary endpoint was the percent change in Severity of Alopecia Tool (SALT) score at 18 months.ResultsTwo hundred and two patients were included. After 18 months of treatment, 55.9%, 42.6% and 29.2% achieved 50%, 75% and 90% reductions in their SALT scores respectively. Increased duration of AA was a negative predictor of hair regrowth. Males and patients with baseline SALT ≥90 were slower to respond to treatment in the first 12 months. One hundred and twenty‐four patients and 168 patients received concomitant systemic corticosteroids or low‐dose oral minoxidil during tofacitinib therapy respectively. There were no serious adverse events.ConclusionTofacitinib was a safe and effective treatment for patients with moderate‐to‐severe AA. Further randomised controlled studies are needed to establish the optimal treatment regimen.
Antibiotic or gastric acid inhibitor use during pregnancy and postpartum depression: Population‐based cohort study
Authors: Gudnadottir Unnur , Kamau Njeri , Fornes Romina , Nguyen Minh Hanh , Callens Steven , Fransson Emma , Engstrand Lars , Bruyndonckx Robin , Brusselaers Nele 
Published: June 2024

AbstractIntroductionPostpartum depression is one of the most common non‐obstetric postnatal complications. As the microbiome (and gut–brain axis) as well as inflammation may be involved in the mechanism, we aimed to assess if antibiotic or gastric acid inhibition use during pregnancy affects the risk of postpartum depression (clinical diagnosis and/or antidepressant use up to 1 year after childbirth).Material and MethodsThis population‐based cohort study used first singleton pregnancy resulting in a live birth in Sweden from 2006 to 2016. Women with history of depression were excluded. Multivariable logistic regression models were used to assess the impact of antibiotics and gastric acid inhibitors and other risk factors, presented as odds ratios (ORs) with 95% confidence intervals (CI).ResultsOverall, 29% of all 10 666 women with postpartum depression were exposed to antibiotics and 6.2% to gastric acid inhibitors, compared to, respectively, 21% and 3.2% of 613 205 women without postpartum depression. Antibiotic use during pregnancy was associated with postpartum depression (OR 1.43, 95% CI 1.37–1.49), particularly for quinolones and other antibacterials (including nitroimidazole derivatives). Gastric acid inhibition was associated with an even higher risk than antibiotics (OR 2.04, 95% CI 1.88–2.21). Both antibiotics and gastric acid inhibitors suggested higher risk with increased dose in a dose–response analysis.ConclusionsThe use of antibiotics and gastric acid inhibition drugs during pregnancy appeared to be associated with a higher risk of postpartum depression. However, it is important to consider that other predisposing factors could contribute to this increased risk, even after excluding individuals with a history of depression.
Calcium mass balance in adults during single hemodialysis and hemodiafiltration treatments using lower calcium dialysate concentrations
Authors: Chhabra Roohi , Davenport Andrew 
Published: June 2024

AbstractBackgroundDebate continues as to the optimum hemodialysis (HD) dialysate calcium concentration. Although current guidelines advocate 1.25–1.5 mmol/L, some investigators have suggested these may cause calcium gains. As such we investigated whether using dialysate calcium of 1.25 mmol/L risked calcium gains, and whether there were differences between hemodiafiltration and high flux HD.MethodsWe continuously collect an aliquot of effluent dialysate during dialysis sessions, and calculated dialysis calcium mass balance by the difference between the amount of calcium delivered as fresh dialysate and that lost in effluent dialysate.ResultsWe studied 106 stable outpatients, 64% male, mean age 64.4 ± 16.2 years, median dialysis vintage 32 (22–60) months. Most sessions (69%) used a 1.0 mmol/L calcium dialysate, with a median sessional loss of 13.7 (11.5–17.1) mmol, whereas using 1.25 mmol/L the median loss was 7.4 (4.9–10.1) mmol, but with 6.9% had a positive balance (p = 0.031 vs dialysate calcium 1.0 mmol/L). Most patients (85.8%) were treated by hemodiafiltration, but there was no difference in sessional losses (11.7 (8.4–15.8) vs 13.5 (8.1–16.8)) with high flux HD. Dialysis sessional calcium balance was associated with the use of lower dialysate calcium concentration (β −19.5, 95% confidence limits (95%CL) −27.7 to −11.3, p < 0.001), and sessional duration (β 0.07 (95% CL) 0.03–012, p = 0.002).ConclusionIdeally, the choice of dialysate calcium should be individualized, but clinicians should be aware, that even when using a dialysate calcium of 1.25 mmol/L, some patients are at risk of a calcium gain during hemodiafiltration and high‐flux hemodialysis.
The potential mechanism of WT1‐associated protein‐induced N‐6‐methyladenosine modification of colony‐stimulating factor 2 in the progression of oral squamous cell carcinoma by JAK/STAT3 pathway regulation
Authors: Peng Ruobing , Jiang Shengjun , Jin Zhongzhi 
Published: June 2024

AbstractColony‐stimulating factor 2 (CSF2) plays a regulatory role in numerous cancers. However, there is needed to investigate the role of CSF2 in oral squamous cell carcinoma (OSCC) malignant phenotype and the specific mechanisms of CSF2 N‐6‐methyladenosine (m6A) modification. Therefore, we investigated the regulatory mechanism of m6A‐modified CSF2 by WT1‐associated protein (WTAP) in OSCC via qRT–PCR, western blot, WTAP and CSF2 overexpression in OSCC. In a panel of OSCCs, Kaplan–Meier plot analysis indicated that high expression of CSF2 was associated with poorer prognosis. Cell functional experiments revealed that enrichment of CSF2 promoted the proliferation and migration of OSCC cells by activating the JAK/STAT3 pathway, whereas the reduced expression of CSF2 resulted in the malignant decline of OSCC cells by blocking the JAK/STAT3 pathway. This study also confirmed that WTAP enhanced the m6A level of CSF2 and facilitated the expression of CSF2 and that CSF2 silencing blocked the invasive phenotype of OSCC cells and reversed the malignancy induced by WTAP overexpression. Overall, this study demonstrated that WTAP mediates the m6A modification of CSF2 and the JAK/STAT3 pathway, which plays an oncogenic role in the development of OSCC and can be a target for the treatment of patients with OSCC.
Oral status of older adults receiving home medical care: A cross‐sectional study
Authors: Tanaka Kumi , Tominaga Tomokazu , Kikutani Takeshi , Sakuda Taeko , Tomida Hiroko , Tanaka Yuko , Mizukoshi Arato , Ichikawa Yoko , Ozeki Maiko , Takahashi Noriaki , Tamura Fumiyo 
Published: June 2024

AimThis study examined the oral status and the presence of teeth requiring treatment among older adults receiving home medical care.MethodsThis cross‐sectional study was conducted at a Japanese dental clinic specializing in geriatric treatment. We recruited older adults receiving home medical care in the community who had begun to receive domiciliary dental care. The Japanese version of the Oral Health Assessment Tool (OHAT‐J), as well as the presence of teeth requiring extraction and the need for assistance in maintaining oral hygiene were used to evaluate the participants' oral health and its association with other items.ResultsNinety‐three participants (44 male and 49 female, median age: 87.0 years) were surveyed. The median OHAT‐J score was 6. The duration since the previous dental visit was 23 months. Sixty‐two (73.8%) of 84 participants with ≥1 natural tooth had severe caries or teeth with severe mobility that required extraction. Logistic analysis revealed that requiring assistance in maintaining oral hygiene, mild dementia, severe dementia, and depression were significantly associated with an OHAT score of ≥6.ConclusionsOlder adults receiving home medical care had poor oral health, with approximately 70% of them requiring tooth extraction. The need for assistance in maintaining oral hygiene and poor mental status contribute to poor oral health. Geriatr Gerontol Int 2024; 24: 706–714.
Deciphering lung adenocarcinoma evolution: Integrative single‐cell genomics identifies the prognostic lung progression associated signature
Authors: Zhang Pengpeng , Yang Zijun , Liu Zuo , Zhang Ge , Zhang Lianmin , Zhang Zhenfa , Fan Jun 
Published: June 2024

AbstractWe employed single‐cell analysis techniques, specifically the inferCNV method, to dissect the complex progression of lung adenocarcinoma (LUAD) from adenocarcinoma in situ (AIS) through minimally invasive adenocarcinoma (MIA) to invasive adenocarcinoma (IAC). This approach enabled the identification of Cluster 6, which was significantly associated with LUAD progression. Our comprehensive analysis included intercellular interaction, transcription factor regulatory networks, trajectory analysis, and gene set variation analysis (GSVA), leading to the development of the lung progression associated signature (LPAS). Interestingly, we discovered that the LPAS not only accurately predicts the prognosis of LUAD patients but also forecasts genomic alterations, distinguishes between ‘cold’ and ‘hot’ tumours, and identifies potential candidates suitable for immunotherapy. PSMB1, identified within Cluster 6, was experimentally shown to significantly enhance cancer cell invasion and migration, highlighting the clinical relevance of LPAS in predicting LUAD progression and providing a potential target for therapeutic intervention. Our findings suggest that LPAS offers a novel biomarker for LUAD patient stratification, with significant implications for improving prognostic accuracy and guiding treatment decisions.
Life, complexity, and psychotherapy: A systemic perspective on the elusive construct of extra‐therapeutic factors
Authors: Tramonti Francesco , Saviozzi Valentina , Ferrante Benedetta , Saliani Simone , Galeazzi Enrico , Vatteroni Simona , Genovesi Ilaria , Di Vecchio Ilaria , Možina Miran 
Published: June 2024

AbstractStudy AimsDespite being mentioned in well‐known models of psychotherapeutic change, the concept of extra‐therapeutic factors seems to have left the scene across time, eaten away by the progressive refinement of the construct of common factors. Aim of the present study is to better understanding the historical evolution of the concept of extra‐therapeutic factors and its importance for psychotherapy today.MethodsThis is a position paper based on a literature review on extra‐therapeutic factors and psychotherapy outcome and process.DiscussionThere is growing evidence of the decisive role of clients' and therapists' characteristics, as well as of the importance of therapeutic alliances and relationships in promoting change. Within this context, the concept of extra‐therapeutic factors still deserves proper attention, rather than being relegated to a residual and vanishing category.ConclusionA renewed interest on extra‐therapeutic factors could reinvigorate the debate over the relationship between psychotherapy and life contexts and conditions. In terms of complexity and systems thinking nothing, a priori, really falls outside the realm of psychotherapy and, in turn, psychotherapy is not a practice that could be abstracted from the context in which it is practiced or from clients' and therapists' lives.