bluuebunny/crossref_metadata_2025_split huggingface dataset:
Implementing an evidence‐based behavioral weight‐loss program in community mental health centers: A randomized pilot study
Authors: Gudzune Kimberly A. , Jerome Gerald J. , Goldsholl Stacy , Dalcin Arlene T. , Gennusa Joseph V. , Fink Tyler , Yuan Christina T. , Brown Kristal L. , Minahan Eva , Wang Nae‐Yuh , Daumit Gail L. 
Published: May 2024

AbstractBackgroundObesity is a leading cause of preventable death among individuals with serious mental illness (SMI). A prior randomized controlled trial demonstrated the efficacy of a lifestyle style intervention tailored to this population; however, such interventions need to be adapted and tested for real‐world settings.AimsThis study evaluated implementation interventions to support community mental health program staff to deliver an evidence‐based lifestyle intervention to clients with obesity and SMI.Materials & MethodsIn this cluster‐randomized pilot trial, the standard arm combined multimodal training with organizational strategy meetings and the enhanced arm included all standard strategies plus performance coaching. Staff‐coaches delivered a 6‐month group‐based lifestyle intervention to clients with SMI. Primary outcomes were changes in staff knowledge, self‐efficacy, and fidelity scores for lifestyle intervention delivery. Linear mixed‐effects modeling was used to analyze outcomes, addressing within‐site clustering and within‐participant longitudinal correlation of outcomes.ResultsThree sites were in the standard arm (7 staff‐coaches); 5 sites in the enhanced arm (11 staff‐coaches). All sites delivered all 26 modules of the lifestyle intervention. Staff‐coaches highly rated the training strategy's acceptability, feasibility and appropriateness. Overall, mean knowledge score significantly increased pre‐post by 5.5 (95% CI: 3.9, 7.1) and self‐efficacy was unchanged; neither significantly differed between arms. Fidelity ratings remained stable over time and did not differ between arms. Clients with SMI achieved a mean 6‐month weight loss of 3.8 kg (95% CI: 1.6, 6.1).ConclusionsMental health staff delivering a lifestyle intervention was feasible using multicomponent implementation interventions, and preliminary results show weight reduction among clients with SMI. The addition of performance coaching did not significantly change outcomes. Future studies are needed to definitively determine the effect on client health outcomes.
“Everyone screens to some extent”: Barriers and facilitators of developmental screening among children with sickle cell disease: A mixed methods study
Authors: Hoyt Catherine R. , Luo Lingzi , Rice Hannah E. , Shivakumar Nirmala , Housten Ashley J. , Picinich Abigail , Qashou Nai , Harris Kelly M. , Varughese Taniya , King Allison A. 
Published: May 2024

AbstractBackgroundDevelopmental delays are common among children with sickle cell disease (SCD). Existing guidelines support consistent screening to increase the identification of deficits and support referral to rehabilitative interventions, yet adherence remains variable. This study sought to assess current practices and identify barriers and facilitators to improve developmental screening for children 0–3 years with SCD.ProcedureA mixed methods approach, guided by the Exploration and Preparation stages of the Exploration, Preparation, Implementation, and Sustainment (EPIS) framework, assessed developmental screening practices among primary care providers and hematologists. Phase 1 included the SCD Developmental Surveillance and Screening Guideline and Practice Survey. Phase 2 included the SCD Developmental Screening Organizational Survey alongside semi‐structured interviews. Descriptive and qualitative methods summarized the findings.ResultsThirty‐three providers from general pediatrics and hematology completed phase 1. Use of standardized developmental screening measures was variable, with the most frequently used being the Modified Checklist for Autism in Toddlers (77%) and the Ages and Stages Questionnaire (55%). Fifteen providers participated in phase 2, and reported they were most likely to engage in changes to improve their practice (mean = 4.4/5) and least likely to support spiritual health and well‐being (mean = 3.5/5). Three themes emerged:(i) developmental screening is not standardized or specific to SCD, (ii) children with SCD benefit from a multidisciplinary team, and (iii) healthcare system limitations are a barrier.ConclusionsDevelopmental screening is inconsistent and insufficient for young children with SCD. Providers are interested in supporting children with SCD, but report a lack of standardized measures and consistent guidance as barriers.
Treatment of newly diagnosed severe aplastic anemia in children: Evidence‐based recommendations
Authors: Shimano Kristin A. , Rothman Jennifer A. , Allen Steven W. , Castillo Paul , de Jong Jill L. O. , Dror Yigal , Geddis Amy E. , Lau Bonnie W. , McGuinn Catherine , Narla Anupama , Overholt Kathleen , Pereda Maria A. , Sharathkumar Anjali , Sasa Ghadir , Nakano Taizo A. , Myers Kasiani , Gloude Nicholas J. , Broglie Larisa , Boklan Jessica 
Published: May 2024

AbstractSevere aplastic anemia (SAA) is a rare potentially fatal hematologic disorder. Although overall outcomes with treatment are excellent, there are variations in management approach, including differences in treatment between adult and pediatric patients. Certain aspects of treatment are under active investigation in clinical trials. Because of the rarity of the disease, some pediatric hematologists may have relatively limited experience with the complex management of SAA. The following recommendations reflect an up‐to‐date evidence‐based approach to the treatment of children with newly diagnosed SAA.
Lysinuric protein intolerance with novel mutations in solute carrier family 7A member 7 in a Chinese family
Authors: Pang Yilin , Huo Feng , Liu Xiao , Fan Yimu , Zhang Zhezhe , Wu Jie , Wang Quan 
Published: May 2024

ABSTRACTIntroductionLysinuric protein intolerance (LPI) is a rare genetic disorder caused by mutations in the solute carrier family 7A member 7 (SLC7A7) gene.Case presentationWe presented two siblings with LPI, carrying novel mutations of c.776delT (p.L259Rfs*18) and c.155G>T (p.G52V) in SLC7A7. The younger sibling, preferring protein‐rich foods, showed severe symptoms, including alveolar proteinosis, macrophage activation syndrome, severe diarrhea, and disturbance of consciousness with involuntary movements. In contrast, the elder sibling only had mild symptoms, likely due to aversion to protein‐rich food since toddler age.ConclusionLPI is a congenital genetic metabolic disease with multi‐system involvement. Initiating appropriate protein‐restricted diet therapy as soon as possible could help prevent the progression of LPI.
Plant reproduction research in Latin America: Toward sustainable agriculture in a changing environment
Authors: Ronceret Arnaud , Bolaños‐Villegas Pablo 
Published: May 2024

AbstractFood production and food security depend on the ability of crops to cope with anthropogenic climate change and successfully produce seed. To guarantee food production well into the future, contemporary plant scientists in Latin America must carry out research on how plants respond to environmental stressors such as temperature, drought, and salinity. This review shows the opportunities to apply these results locally and abroad and points to the gaps that still exist in terms of reproductive processes with the purpose to better link research with translational work in plant breeding and biotechnology. Suggestions are put forth to address these gaps creatively in the face of chronic low investment in science with a focus on applicability.
Assessing the functional impact of protein binding site definition
Authors: Nandigrami Prithviraj , Fiser Andras 
Published: May 2024

AbstractMany biomedical applications, such as classification of binding specificities or bioengineering, depend on the accurate definition of protein binding interfaces. Depending on the choice of method used, substantially different sets of residues can be classified as belonging to the interface of a protein. A typical approach used to verify these definitions is to mutate residues and measure the impact of these changes on binding. Besides the lack of exhaustive data, this approach also suffers from the fundamental problem that a mutation introduces an unknown amount of alteration into an interface, which potentially alters the binding characteristics of the interface. In this study we explore the impact of alternative binding site definitions on the ability of a protein to recognize its cognate ligand using a pharmacophore approach, which does not affect the interface. The study also shows that methods for protein binding interface predictions should perform above approximately F‐score = 0.7 accuracy level to capture the biological function of a protein.
Fixed‐time stability of nonlinear impulsive systems: Sufficient criteria and necessary condition
Authors: Wang Yishu , Lu Jianquan , Feng Guizhen , Ding Jian , Jiang Bangxin 
Published: May 2024

AbstractThis article explores the criteria for fixed‐time stability (FxTS) within nonlinear impulsive dynamical systems, encompassing both stabilizing and destabilizing impulses. Initially, employing the Lyapunov method, the article delineates a criterion for FxTS, particularly when impulsive sequences are delineated by an average impulsive interval. Following this, the article innovatively applies two integral inequalities to introduce an optimized criterion for uniform impulsive sequences, evidencing its lesser conservativeness relative to the initial criterion. Moreover, this article derives a necessary condition for dynamical systems subjected to destabilizing impulses. Intriguingly, the investigation reveals the existence of a minimal threshold for the maximum impulsive interval, below which the system cannot achieve FxTS. This result elucidates why existing literature uniformly imposes a specific condition on the impulsive interval for destabilizing impulses. Finally, the efficacy of the proposed theory is underscored through numerical examples.
Solvent‐Free Synthesis of PMMA Particles using Tandem Acoustic Emulsification
Authors: Baissac L. , Salvi T. , Jurin F. E. , Pochard I. , Hihn J.‐Y. , Buron C. C. 
Published: May 2024

AbstractPoly(methyl methacrylate) (PMMA) colloidal particles are nowadays extensively used in several applications and more specifically in nanotechnology. Challenges are focused on the green synthesis process leading to size‐controlled particles. In the present work, PMMA particles were successfully synthesized using tandem acoustic emulsification in water without organic solvent, and cross‐linkers. 2,2′‐azobis(2‐methylpropionamidine) dihydrochloride (AIBA) or ammonium persulfate (APS), were used as initiators. Parameters leading to size control were clearly identified. Consequently, the cooling rate of the solution after polymerization time appears dominating. Particle size distribution was monodispersed for both initiators. A nonionic surfactant, Tween 20, was also added, leading to a decrease in size particle and an increase in synthesis yield. Depending on the chemical groups provided by the initiator, PMMA particles appear negatively or positively charged. These charges located on the particle surface led to stable particle dispersion by limiting aggregation phenomena. Tunable surface charge was confirmed across the elaboration of coatings only made of PMMA particles, using conventional techniques wherein charged species are needed (Layer‐by‐Layer assembly and electrophoretic deposition). PMMA particles were also labelled using fluorescent dyes. Fluorescein and Nile Blue A were loaded during the polymerization process to ensure a homogeneous distribution of the dyes within the particles.
Making a vicious cycle virtuous: A research and policy agenda for advancing the water security of unregulated users in the Southwestern U.S.
Authors: Dobbin Kristin Babson , Hernandez Ariana , Bostic Darcy , Harrison Grace , Singhal Aaryaman , Barnett Matthew , Vasquez‐Rodriguez Itzel , Pierce Gregory , Sawyer Kate 
Published: May 2024

AbstractIn the United States, most residents receive water from centralized utilities regulated under the federal Safe Drinking Water Act. Yet, a sizable portion of U.S. residents satisfy their household water needs through decentralized means, including domestic wells, very small water systems, and hauled water. These federally unregulated water users are among the most vulnerable to the impacts of climate change, particularly in aridifying regions like the Southwest. They are, however, inconsistently monitored and regulated at the Tribal, federal, state, and local levels. Compared to regulated users, very few programs exist to assist this population in securing and maintaining safe, affordable drinking water access. This neglect creates a vicious cycle whereby their water security needs remain both poorly understood and inadequately addressed. We review available data sources, regulations, assistance programs, and published studies relevant to unregulated water users across the Southwestern U.S. to illustrate this injurious feedback loop. We then propose four key areas for intervention to transform this vicious cycle into a virtuous one. Drawing on new insights from the emerging literature on modular, adaptive, and decentralized (MAD) water infrastructure, we highlight opportunities for investment and innovation to support decentralized service alongside existing investments in centralized infrastructure, and the critical need to attend to justice in the design and implementation of such policies.This article is categorized under:
Science of Water > Water and Environmental Change
Human Water > Water Governance
Human Water > Rights to Water
A systematic review and meta‐analysis of neoadjuvant imatinib use in locally advanced and metastatic gastrointestinal stromal tumors
Authors: Lam Timothy Jia Rong , Udonwa Shamill Amedot , Masuda Yoshio , Yeo Mark Hao Xuan , Farid bin Harunal Ras Mohamad , Goh Brian K. P. 
Published: May 2024

AbstractBackgroundSeveral doubts remain regarding the optimal use of neoadjuvant imatinib in gastrointestinal stromal tumors (GISTs), such as ideal treatment duration, patient selection, and long‐term survival outcomes. This manuscript provides a comprehensive review on neoadjuvant imatinib treatment outcomes and facilitate evidence‐based decision‐making for the use of imatinib therapy in GISTs.MethodsFour databases (PubMed, EMBASE, Scopus, and Cochrane Library) were searched from inception to September 9, 2023. Meta‐analyses of proportions were performed for the outcomes of R0 resection, disease responses, and 1‐year, 3‐year, and 5‐year overall survival (OS) as well as 1‐year, 3‐year, and 5‐year disease free survival (DFS). Sensitivity analyses in the form of leave‐one‐out analyses, meta‐regression, and subgroup analyses were performed for outcomes with substantial statistical heterogeneity.ResultsThe search yielded 1254 articles, and 36 studies were included in our analysis. Meta‐analysis of proportions revealed that 1‐year, 3‐year, and 5‐year OS was 100%, 94%, and 88%, while 1‐year, 3‐year and 5‐year DFS was 99%, 89%, and 79%, respectively. An R0 resection rate of 89% and a disease response rate of 67% was achieved after a mean duration of treatment of 8.41 ± 0.367 months. KIT exon 9 mutation was significantly associated with poorer 5‐year DFS.ConclusionThis study quantified key outcomes for neoadjuvant imatinib in locally advanced and metastatic or recurrent GIST. Patients with gastric and rectal tumous stand to benefit from neoadjuvant imatinib with an optimal treatment duration of 8 months. Furthermore, the potential utility of mutational analysis in guiding treatment with neoadjuvant imatinib was demonstrated.
The development of nanocarriers for natural products
Authors: Huang Liying , Luo Shicui , Tong Sen , Lv Zhuo , Wu Junzi 
Published: May 2024

AbstractNatural bioactive compounds from plants exhibit substantial pharmacological potency and therapeutic value. However, the development of most plant bioactive compounds is hindered by low solubility and instability. Conventional pharmaceutical forms, such as tablets and capsules, only partially overcome these limitations, restricting their efficacy. With the recent development of nanotechnology, nanocarriers can enhance the bioavailability, stability, and precise intracellular transport of plant bioactive compounds. Researchers are increasingly integrating nanocarrier‐based drug delivery systems (NDDS) into the development of natural plant compounds with significant success. Moreover, natural products benefit from nanotechnological enhancement and contribute to the innovation and optimization of nanocarriers via self‐assembly, grafting modifications, and biomimetic designs. This review aims to elucidate the collaborative and reciprocal advancement achieved by integrating nanocarriers with botanical products, such as bioactive compounds, polysaccharides, proteins, and extracellular vesicles. This review underscores the salient challenges in nanomedicine, encompassing long‐term safety evaluations of nanomedicine formulations, precise targeting mechanisms, biodistribution complexities, and hurdles in clinical translation. Further, this study provides new perspectives to leverage nanotechnology in promoting the development and optimization of natural plant products for nanomedical applications and guiding the progression of NDDS toward enhanced efficiency, precision, and safety.This article is categorized under:
Therapeutic Approaches and Drug Discovery > Emerging Technologies
Nanotechnology Approaches to Biology > Nanoscale Systems in Biology
Challenge or utopia? Reflections on integration in water management in Brazil
Authors: de Sousa Júnior Wilson Cabral 
Published: May 2024

Highlights

The article addresses the state of the art of IWRM in Brazil.
The advances and gaps of IWRM in Brazil are highlighted.
The author revisits the criticism of IWRM in light of its breadth and perspectives.
The text questions the very viability of IWRM in Brazil based on a practical case.
The author presents topics to consider for effective integration in water management in Brazil.
A Radical Theology of Conflict and Contestation
Authors: Caputo John D. 
Published: May 2024

AbstractIn radical thinking, things are never as settled as they seem. Underneath the appearance of continuity lie ruptures and interruptions, underneath identity, difference. Hence, the identity of the one theology, the one Christian revelation, the one history of Christianity, is contested at its root. That is not meant to demolish Christian theology but to show that it is not identical with itself. This project is undertaken not from a love of chaos and confusion but to keep the future of Christianity open. The most effective way to contest something is to write a meticulous history of it, as illustrated by the early history of Christianity before it was canonized and Neoplatonized by the councils, which is where the myth of the one Christianity was invented. Christianity does not have an essence; it has a history. Tradition, the Catholic principle, means transmission, which implies constant process and reinvention, in the name of the coming of the future, of the promise of Jesus which the tradition is committed to transmit. The one thing that is uncontestable is always still to come.
Conflicting Masculinities in Christianity: Experiences and Critical Reflections on Gender and Religion
Authors: Schüßler Michael 
Published: May 2024

AbstractThe article discusses the challenges arising from an essentialist approach to masculinity as a stable category with a set of given, unchangeable characteristics developed in contrast to femininity. Such a hegemonic view is a stumbling block in the development of more diverse and inclusive environments, to which the Catholic Church contributes by its defense of “traditional” family, the ideal of clerical men or the discrimination of queer living. The text argues for recognition and normalization of diversity, instead of a continuous reproduction of toxic ideals of masculinity. In this sense, conflicting masculinities in church and theology could be a perspective of hope for transformation: Hegemonic masculinity no longer goes unchallenged, not even in Catholic Church.
Searching for a Lost PPW: SS William Rockefeller
Authors: Detlie John 
Published: May 2024

AbstractPossibly the most unfortunate legacy of the Battle of the Atlantic is the great number of wrecks lying in coastal and marine waters that still contain oil, unexploded ordnance, and other pollution or safety hazards. This has become an increasingly pressing issue in recent years, as these wrecks are now entering their eighth decade underwater and many are experiencing significant structural degradation due to natural corrosion and anthropogenic causes. While some of these potentially polluting wrecks have been located and steps taken to mitigate their pollution risk, many more remain missing, particularly those which sank in deep water (NOAA, 2013a, b; Symons et al., 2014; Hoyt et al., 2021; Brennan, Chap. 1, this volume).
Concluding Statement
Authors: Sousa Joao , Ferrari Benjamin , Brennan Michael L. , Varmer Ole 
Published: May 2024

AbstractThe grim reality of potentially polluting legacy wrecks presents a multifaceted threat that extends far beyond the decaying hulks on the ocean floor. These wrecks serve as silent sentinels of a bygone era, leaking toxic substances that indiscriminately poison marine life and disrupt the intricate web of oceanic relationships. From the smallest plankton to the largest apex predators, no organism remains untouched by the effects of these pollution sources.
Potentially Polluting Wrecks in the Blue Pacific
Authors: Carter Matthew , Meredith Ashley , Kohler Augustine C. , Mori Bradford , Walter Ranger 
Published: May 2024

AbstractMarine pollution is a global and transboundary issue that negatively affects the environment, people, and coastal economies around the world. It is widely recognised as one of the four major threats to the world’s oceans, along with climate change, habitat destruction and over-exploitation of living marine resources (SPREP, 2020). Since the large-scale introduction of oil-fueled shipping in the 1930s, marine pollution incidents have occurred in practically all coastal waters across the globe. In the Pacific Region the greatest concentration of these incidents stemmed from the loss of over 3800 ships during the World War II (WWII) (SPREP, 2003a, b) (Fig. 8.1). At the time of their loss, these ships contained as many as 1.5 billion gallons of petrochemicals, and hundreds of thousands of tons of explosive ordnance (Michel et al., 2005), an unknown amount of which remains in these wrecks today.
Wie die Arbeitslosenversicherung die Wirtschaft stabilisiert
Authors: Maassen Isabella 
Published: May 2024

ZusammenfassungDie Arbeitslosenversicherung schützt die Arbeitenden vor grösseren Einkommensausfällen in der Rezession und hilft, den Wohlstand über die Zeit zu glätten. Sie ist auch ein wichtiger automatischer Stabilisator, der die Konjunkturschwankungen dämpft. Gerade die Arbeitslosen haben häufig eine hohe Konsumquote und geben in der Rezession jedes zusätzliche Einkommen aus. Die Absicherung der Einkommen stützt zudem die Kreditfähigkeit der Haushalte. Eine solide finanzierte Arbeitslosenversicherung stabilisiert die Konsumnachfrage und festigt die Widerstandskraft der Wirtschaft.
Wie die Grossfamilie ihre Kinder fördert
Authors: Hermanns Charlotte 
Published: May 2024

ZusammenfassungEltern wenden viel Zeit auf und geben ein Vermögen aus, um ihre Kinder zu fördern. Je höher Einkommen und Bildung sind, desto besser gelingt es ihnen. Auch Onkel, Tanten, die weitere Verwandtschaft und die Grosseltern üben einen wichtigen Einfluss aus, indem sie Zeit mit den Kindern verbringen, als Vorbild dienen, und Normen und Werte weitergeben.