bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of multiple doses of T‐2 toxin on the erythroid response capacity of mice following an extensive experimental bleeding
Authors: Godoy Héctor M. , Faifer Graciela C. , Velazco Viviana 
Published: June 2010

AbstractTotal nucleated cellularity and total erythroid cell populations were measured in spleen and bone marrow of mice at different times after treatment with 3 daily doses of T‐2 toxin (2.0 mg/kg). It was found that the initial depletion of hematopoietic cells produced by the toxin was rapidly reverted in spleen, giving way after 48 hr to a significant hypercellularity which after 10 days was 2.5 times the normal levels, but this effect was not observed in bone marrow, which slowly recovered normal cellularity after 5 days. The cytological analysis revealed that there was a highly significant shift in the ratio of erythroid to non‐erythroid cells, since erythroid cell populations increased by about 8‐fold in spleen and nearly 2‐fold in bone marrow between 10 and 35 days after intoxication. In order to test the integrity of the hematopoietic reserve capacity, a hemorrhagic stress was produced in intoxicated animals at 10–50 days after toxin exposure. It was found that the erythroid response capacity was significantly higher in the intoxicated animals compared to anemic controls. The results suggest that the initial cytotoxic damage produced by T‐2 toxin in the hematopoietic system is followed by a significant erythroid hypercellularity, which can confer an increased capacity for response to a hemorrhagic emergency. Nat. Toxins 5:152–156, 1997. © 1997 Wiley‐Liss, Inc.
Preparation of Defined Human Embryonic Stem Cell Populations for Transcriptional Profiling
Authors: Zhou Qi , Chy Hun , Laslett Andrew L. 
Published: June 2010

AbstractThis unit describes a useful approach to preparing highly reproducible samples of human embryonic stem cell (hESC) total RNA suitable for transcriptional profiling from heterogeneous mixtures of cells containing undifferentiated hESC and differentiated cell types. In this unit, fluorescence‐activated cell sorting (FACS) is used to sub‐fractionate hESC populations on the basis of their levels of co‐expression of two previously published hESC surface markers, CD9(TG30) and GCTM‐2. This sub‐fractionation allows for the separation of undifferentiated hESC (CD9hi, GCTM‐2hi) from the early stages in hESC differentiation (CD9neg or low, GCTM‐2neg or low). Curr. Protoc. Stem Cell Biol. 14:1B.7.1‐1B.7.15. © 2010 by John Wiley & Sons, Inc.
The Influence of Surface Chemistry and Pore Size on the Adsorption of Proteins on Nanostructured Carbon Materials
Authors: Vijayaraj Munusami , Gadiou Roger , Anselme Karine , Ghimbeu Camelia , Vix‐Guterl Cathie , Orikasa Hironori , Kyotani Takashi , Ittisanronnachai Sumlak 
Published: June 2010

AbstractCarbon films are synthesized by templating of anodic aluminum oxide films. These carbon materials exhibit nanochannels with controlled diameter and length. Selected chemical treatments are done to tailor the surface chemistry. The adsorption capacities of bovine serum albumin and cytochrome c are measured by temperature‐programmed desorption with mass spectrometry (TPD‐MS) analysis and with conventional biological assays. The first method allows quantification of the proteins that exhibit strong interactions with the surface, while the second one is used to obtain the total adsorption capacity. Moreover, the TPD‐MS profiles, which are related to the structural modifications of the proteins during the adsorption, show that strong interactions take place with hydrophobic surfaces. When oxygenated functions are present, the adsorption capacity increases and the nature of the interactions is modified. The ratio of irreversible to reversible adsorption is significantly different for the two proteins, and is slightly related to the surface chemistry. The influence of nanochannel size is studied: below 50 nm, the coverage ratio shows that access to the porosity is limited by diffusion in the channel and by pore plugging, in agreement with the strong interactions of proteins with the carbon surface.
Stable, Glassy, and Versatile Binaphthalene Derivatives Capable of Efficient Hole Transport, Hosting, and Deep‐Blue Light Emission
Authors: Wei Bin , Liu Ji‐Zhong , Zhang Yong , Zhang Jian‐Hua , Peng Hua‐Nan , Fan He‐Liang , He Yan‐Bo , Gao Xi‐Cun 
Published: June 2010

AbstractOrganic light‐emitting diodes (OLEDs) have great potential applications in display and solid‐state lighting. Stability, cost, and blue emission are key issues governing the future of OLEDs. The synthesis and photoelectronics of a series of three kinds of binaphthyl (BN) derivatives are reported. BN1–3are “melting‐point‐less” and highly stable materials, forming very good, amorphous, glass‐like films. They decompose at temperatures as high as 485–545 °C. At a constant current density of 25 mA cm−2, an ITO/BN3/Al single‐layer device has a much‐longer lifetime (>80 h) than that of an ITO/NPB/Al single‐layer device (8 h). Also, the lifetime of a multilayer device based on BN1is longer than a similar device based on NPB. BNs are efficient and versatile OLED materials: they can be used as a hole‐transport layer (HTL), a host, and a deep‐blue‐light‐emitting material. This versatility may cut the cost of large‐scale material manufacture. More importantly, the deep‐blue electroluminescence (emission peak at 444 nm with CIE coordinates (0.16, 0.11), 3.23 cd A−1at 0.21 mA cm−2, and 25200 cd m−2at 9 V) remains very stable at very high current densities up to 1000 mA cm−2.
Self‐Assembled In‐Plane Growth of Mg2SiO4 Nanowires on Si Substrates Catalyzed by Au Nanoparticles
Authors: Zhang Zhou , Wong Lai Mun , Wang Hou Xiao , Wei Zhi Peng , Zhou Wei , Wang Shi Jie , Wu Tom 
Published: June 2010

AbstractIn‐plane growth of Mg2SiO4 nanowires on Si substrates is achieved by using a vapor transport method with Au nanoparticles as catalyst. The self‐assembly of the as‐grown nanowires shows dependence on the substrate orientation, i.e., they are along one, two, and three particular directions on Si (110), (100), and (111) substrates, respectively. Detailed electron microscopy studies suggest that the Si substrates participate in the formation of Mg2SiO4, and the epitaxial growth of the nanowires is confined along the Si <110> directions. This synthesis route is quite reliable, and the dimensions of the Mg2SiO4 nanowires can be well controlled by the experiment parameters. Furthermore, using these nanowires, a lithography‐free method is demonstrated to fabricate nanowalls on Si substrates by controlled chemical etching. The Au nanoparticle catalyzed in‐plane epitaxial growth of the Mg2SiO4 nanowires hinges on the intimate interactions between substrates, nanoparticles, and nanowires, and our study may help to advance the developments of novel nanomaterials and functional nanodevices.
Studies of the biochemical composition of fresh‐water plankton. Part 1: The protein contents in green and blue‐green algae
Authors: Hanušová J. , Havlík B. 
Published: June 2010

AbstractLowry's method, adapted to the analysis of small amounts of fresh‐water plankton, was selected for the basic evaluation of the published methods of determination of proteins in algae.The protein contents were studied by this method in aqueous, alcohol and sodium hydroxide extract from green algae of the types Ankistrodesmus falcatus, Haematococcus pluvialis, Chlorella vulgaris, Scenedesmus obliquus, Pediastrum boryanum, Chlorococcus spec. and from blue‐green algae Microcystis pulverea, M. aeruginosa and Anacystis nidulans. These organisms were cultivated in artificial media under standard conditions and the analysis of proteins was carried out during the growth and stagnation phases.The largest amount of proteins was ascertained in extracts of 2N NaOH, amounting to 7 … 44% according to the dry substance (aqueous extract 1 … 48%, alcohol extract 1 … 23%). As the ageing of the cultures of green algae proceeded, the amount of dry substance increased, but the protein contents decreased. In the samples of blue‐green algae there were in all cases the protein contents higher in the stationary phase than in the growth phase.
Tricarbonyl‐2,7‐methanoaza[10]annulenchrom(0)
Authors: Hilken Günter , Kinkel Tonio , Schwamborn Michael , Lex Johann , Schmickler Hans , Vogel Emanuel 
Published: June 2010

AbstractDas vollständige Manuskript dieser Zuschrift erscheint in: Angew. Chem. Suppl. 1982, 1622. DOI: 10.1002/ange.198216220
[Fe2{o‐(SCH2)2C6H4}2{SC6H5}2]2− und [Fe2{o‐(SCH2)2C6H4}3]2−: Zweikernige Thiolatoeisen(II)‐Anionen mit tetraedrischer FeS4‐Koordination
Authors: Henkel Gerald , Tremel Wolfgang , Krebs Bernt 
Published: June 2010

AbstractDas vollständige Manuskript dieser Zuschrift erscheint in: Angew. Chem. Suppl. 1983, 323. DOI: 10.1002/ange.198303230
Schonende Herstellung und Charakterisierung ligandenfreier Metallcluster in Zeolithen sowie ihre Verwendung als Katalysatoren für die selektive Reduktion von CO zu Buten
Authors: Nazar Linda F. , Ozin Geoffrey A. , Hugues François , Godber John , Rancourt Denis 
Published: June 2010

AbstractDas vollständige Manuskript dieser Zuschrift erscheint in: Angew. Chem. Suppl. 1983, 898. DOI: 10.1002/ange.198308980
Chelat‐ oder Nicht‐Chelat‐Kontrolle bei stereoselektiven Reaktionen von Titan‐Reagentien mit chiralen Alkoxycarbonyl‐Verbindungen
Authors: Reetz Manfred T. , Keßeler Kurt , Schmidtberger Susi , Wenderoth Bernd , Steinbach Rainer 
Published: June 2010

AbstractDas vollständige Manuskript dieser Zuschrift erscheint in: Angew. Chem. Suppl. 1983, 1511. DOI: 10.1002/ange.198315110
Combining Information from Similar Experiments: II. Quantifying Qualitative Results
Authors: Verducci J. S. 
Published: June 2010

AbstractSuppose that independent experiments each indicate general qualitative results, such as higher than normal incidence rates of tumors for exposed populations. This paper suggests methods for amalgamating the qualitative results from several such experiments into a more quantitative form, such as a dose‐response relationship. The methods are designed to be robust both to systematic bias in one of the experiments and also to procedural variability across experiments. Data from four rodent experiments with tolazamide are used to illustrate the methods.
Estimating the Rate of Transfer to a Voluntary Improvement or Rehabilitation Programme Following Capture
Authors: Dayananda P. W. A. , Hogarth W. L. 
Published: June 2010

AbstractA method is developed for determining the effectiveness of counselling individuals to undertake a voluntary improvement or rehabilitation programme following capture. This is achieved by estimating the rate of transfer. Estimates are also obtained of the number who have undertaken the programme previously and those who have not undertaken the programme. For a closed population, the estimated rate of transfer is shown to be unbiased and its variance derived. The estimate is obtained under general conditions and, in the special case, when deaths of drug addicts occur, it is shown that the estimate is approximately unbiased. The theory could also be used to estimate the tag losses/gains due to migration in biological populations when capture‐recapture techniques are used.
Application of Tests and Measures of Associations in the Case of 2×2 Contingency Table with the Examination of Allergen‐Sensitive Asthmatic Children
Authors: Börzsönyi L. , Cserháti E. , Osztie É. 
Published: June 2010

AbstractAuthors investigate the relationship between the early expoeition to allergens and the atopic dimaaea developing a t a later time in asthmatic children. This investigation involves the evaluation of high number of 2×2 contingency tables. A system of conditions ie given for the etatiatid teet to decide on the hypothesee in order to be consequent. In addition to general description of the relationship, 8 special apphostion and operative interpretation of the Somer's measure of association are presented. Determination of similarity among the allergens with cluster analysis yields an interesting parallelism in the results. According to our results the development of specific allergen sensitivity can potentially be reduced in children to be born.
Selection of Log‐Linear Models with Orthonormal Basis for Contingency Tables
Authors: Böker Fred 
Published: June 2010

AbstractA model selection criterion for log‐linear models with orthonormal basis for contingency tables is developed using the Gauss discrepancy between the logarithms of the frequencies. The contribution of each parameter to the criterion may be determined separately. A test for the hypothesis that the use of a certain parameter increases the expected discrepancy is given.
P‐Values for Two‐Sided Tests
Authors: George E. Olusegun , Mudholkar Govind S. 
Published: June 2010

AbstractThe problem of defining P‐values for two‐sided tests is considered when the null density f0 of the associated test statistic is strictly unimodal. It is argued that the usual practice of defining P‐values for two‐sided tests as twice the one‐tail P‐value is only justifable when f0 is symmetric. To accomodate testing problems with asymmetric null distributions a more general definition of two‐sided P‐value is given.
Biosynthesis of lovastatin and related metabolites formed by fungal iterative PKS enzymes
Authors: Campbell Chantel D. , Vederas John C. 
Published: June 2010

AbstractThe fungal polyketide lovastatin is a cholesterol lowering agent that is an immediate precursor to a multi‐billion dollar drug, simvastatin (Zocor™). Lovastatin is produced by an iterative type I polyketide synthase known as LovB and a partner enoyl reductase (LovC). There is evidence that a Diels‐Alderase enzyme activity is utilized in its biosynthesis. This review examines the biosynthesis of lovastatin, as well as of compactin, equisetin, cytochalasins, and solanapyrones, which are other structurally related polyketides that appear to utilize a Diels‐Alderase. © 2010 Wiley Periodicals, Inc. Biopolymers 93: 755–763, 2010.
Cloning large natural product gene clusters from the environment: Piecing environmental DNA gene clusters back together with TAR
Authors: Kim Jeffrey H. , Feng Zhiyang , Bauer John D. , Kallifidas Dimitris , Calle Paula Y. , Brady Sean F. 
Published: June 2010

AbstractA single gram of soil can contain thousands of unique bacterial species, of which only a small fraction is regularly cultured in the laboratory. Although the fermentation of cultured microorganisms has provided access to numerous bioactive secondary metabolites, with these same methods it is not possible to characterize the natural products encoded by the uncultured majority. The heterologous expression of biosynthetic gene clusters cloned from DNA extracted directly from environmental samples (eDNA) has the potential to provide access to the chemical diversity encoded in the genomes of uncultured bacteria. One of the challenges facing this approach has been that many natural product biosynthetic gene clusters are too large to be readily captured on a single fragment of cloned eDNA. The reassembly of large eDNA‐derived natural product gene clusters from collections of smaller overlapping clones represents one potential solution to this problem. Unfortunately, traditional methods for the assembly of large DNA sequences from multiple overlapping clones can be technically challenging. Here we present a general experimental framework that permits the recovery of large natural product biosynthetic gene clusters on overlapping soil‐derived eDNA cosmid clones and the reassembly of these large gene clusters using transformation‐associated recombination (TAR) in Saccharomyces cerevisiae. The development of practical methods for the rapid assembly of biosynthetic gene clusters from collections of overlapping eDNA clones is an important step toward being able to functionally study larger natural product gene clusters from uncultured bacteria. © 2010 Wiley Periodicals, Inc. Biopolymers 93: 833–844, 2010.
Recent developments in bisintercalator natural products
Authors: Zolova Olga E. , Mady Ahmed S. A. , Garneau‐Tsodikova Sylvie 
Published: June 2010

AbstractThe bisintercalator natural products are a family of nonribosomal peptides possessing a range of biological properties that include antiviral, antibiotic, and anticancer activities. The name bisintercalator is derived from the ability to directly bind to duplex DNA through two planar intercalating moieties. Although 19 members of this family of compounds have been identified over the past 50 years, the biosynthetic genes responsible for the formation of four of these molecules (thiocoraline, SW‐163, triostin A, and echinomycin) were identified only recently. This recent progress opens an avenue towards understanding how Nature produces these bisintercalating products and provides the potential to develop and identify novel potent analogous lead compounds for clinical applications. This review discusses the mode of action of bisintercalators and summarizes recent genetic and biochemical insights into their biosynthetic production, analog formation, and possible mechanisms by which resistance to these compounds is achieved by their producing organisms. © 2010 Wiley Periodicals, Inc. Biopolymers 93: 777–790, 2010.
Comparison of simultaneous or delayed liver surgery for limited synchronous colorectal metastases
Authors: de Haas R J , Adam R , Wicherts D A , Azoulay D , Bismuth H , Vibert E , Salloum C , Perdigao F , Benkabbou A , Castaing D 
Published: June 2010

Abstract

Background
The optimal surgical strategy for patients with synchronous colorectal liver metastases (CLMs) is still unclear. The aim of this study was to compare simultaneous colorectal and hepatic resection with a delayed strategy in patients who had a limited hepatectomy (fewer than three segments).

Methods
All patients with synchronous CLMs who underwent limited hepatectomy between 1990 and 2006 were included retrospectively. Short-term outcome, overall and progression-free survival were compared in patients having simultaneous colorectal and hepatic resection and those treated by delayed hepatectomy.

Results
Of 228 patients undergoing hepatectomy for synchronous CLMs, 55 (24·1 per cent) had a simultaneous colorectal resection and 173 (75·9 per cent) had delayed hepatectomy. The mortality rate following hepatectomy was similar in the two groups (0 versus 0·6 per cent respectively; P = 0·557), but cumulative morbidity was significantly lower in the simultaneous group (11 per cent versus 25·4 per cent in the delayed group; P = 0·015). Three-year overall and progression-free survival rates were 74 and 8 per cent respectively in the simultaneous group, compared with 70·3 and 26·1 per cent in the delayed group (overall survival: P = 0·871; progression-free survival: P = 0·005). Significantly more recurrences were observed in the simultaneous group at 3 years (85 versus 63·6 per cent; P = 0·002); a simultaneous strategy was an independent predictor of recurrence.

Conclusion
Combining colorectal resection with a limited hepatectomy is safe in patients with synchronous CLMs and associated with less cumulative morbidity than a delayed procedure. However, the combined strategy has a negative impact on progression-free survival.
Endovenous therapy for deep venous thrombosis: The TORPEDO trial
Authors: Sharifi Mohsen , Mehdipour Mahshid , Bay Curt , Smith Gary , Sharifi Jalaladdin 
Published: June 2010

AbstractObjectives. We compared the efficacy and safety of percutaneous endovenous intervention (PEVI) plus anticoagulation with anticoagulation alone in the reduction of venous thromboembolism (VTE) and post‐thrombotic syndrome (PTS) in acute proximal deep venous thrombosis (DVT). Background. Recurrent VTE and PTS are common complications of DVT. There are no randomized trials investigating the efficacy of PEVI in the reduction of the above complications. Methods. Patients with symptomatic proximal DVT were randomized to receive PEVI plus anticoagulation or anticoagulation alone. Anticoagulation consisted of intravenous unfractionated heparin or subcutaneous low‐molecular weight heparin plus warfarin. PEVI consisted of one or more of a combination of thrombectomy, balloon venoplasty, stenting, or local low‐dose thrombolytic therapy. Results. At 6 months follow‐up, recurrent VTE developed in 2 of 88 patients of the PEVI plus anticoagulation group versus 12 of 81of the anticoagulation‐alone group (2.3% vs. 14.8%, P = 0.003). PTS developed in 3 of 88 patients of the PEVI plus anticoagulation Group and 22 of 81 of the anticoagulation‐alone group (3.4% vs. 27.2%, P < 0.001). Conclusions. In patients with symptomatic proximal DVT, PEVI plus anticoagulation may be superior to anticoagulation—alone in the reduction of VTE and PTS at 6 months. © 2010 Wiley‐Liss, Inc.
Awareness of anatomical variations for infrapopliteral intervention
Authors: Kawarada Osami , Yokoi Yoshiaki , Honda Yasuhiro , Fitzgerald Peter J. 
Published: June 2010

AbstractWith the tremendous advancement and accumulated expertise of endovascular techniques, infrapopliteal intervention is emerging as an alternative therapeutic option to distal bypass surgery for limb salvage in the setting of critical limb ischemia (CLI). However, though much attention has been given to infrapopliteal intervention, the importance of identifying preprocedural infrapopliteal variants remains underappreciated. Becoming more aware of these anatomical variants will translate to increased clinical effectiveness for the patient with infrapopliteal artery disease. Therefore, this review will highlight the fundamental aspects of infrapopliteal variant anatomy for the catheter‐based treatment of CLI patients with symptomatic infrapopliteal artery disease.© 2010 Wiley‐Liss, Inc.
ChemInform Abstract: Crystal Structure of UCu5In.
Authors: ZAREMBA V. , STEPIEN‐DAMM J. , TROC R. , KACZOROWSKI D. 
Published: June 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: The Magnetic Ordering of Ln6Fe13X Compounds.
Authors: SCHOBINGER‐PAPAMANTELLOS P. , BUSCHOW K. H. J. , DE GROOT C. H. , DE BOER F. R. , RITTER C. , FAUTH F. , BOETTGER G. 
Published: June 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Lanthanum Nickel Silicides with the General Formula La(n+1)(n+2)Nin(n‐1)+2Sin(n+1) and Other Series of Hexagonal Structures with Metal:Metalloid Ratios Close to 2:1.
Authors: PROTS' YU. M. , JEITSCHKO W. 
Published: June 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Flux Synthesis of LiAuS and NaAuS: “Chicken‐Wire‐Like” Layer Formation by Interweaving of (AuS)n‐n Threads. Comparison with α‐HgS and MAuS (M: K, Rb).
Authors: AXTELL E. A. III , LIAO J.‐H. , KANATZIDIS M. G. 
Published: June 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.