bluuebunny/crossref_metadata_2025_split huggingface dataset:
Disrupting the epileptogenic network with stereoelectroencephalography‐guided radiofrequency thermocoagulation
Authors: Kreinter Hellen , Espino Poul H. , Mejía Sonia , Alorabi Khalid , Gilmore Greydon , Burneo Jorge G. , Steven David A. , MacDougall Keith W. , Jones Michelle‐Lee , Pellegrino Giovanni , Diosy David , Mirsattari Seyed M. , Lau Jonathan , Suller Marti Ana 
Published: May 2024

AbstractStereoelectroencephalography‐guided radiofrequency thermocoagulation (SEEG‐guided RF‐TC) is a treatment option for focal drug‐resistant epilepsy. In previous studies, this technique has shown seizure reduction by ≥50% in 50% of patients at 1 year. However, the relationship between the location of the ablation within the epileptogenic network and clinical outcomes remains poorly understood. Seizure outcomes were analyzed for patients who underwent SEEG‐guided RF‐TC and across subgroups depending on the location of the ablation within the epileptogenic network, defined as SEEG sites involved in seizure generation and spread. Eighteen patients who had SEEG‐guided RF‐TC were included. SEEG‐guided seizure‐onset zone ablation (SEEG‐guided SOZA) was performed in 12 patients, and SEEG‐guided partial seizure‐onset zone ablation (SEEG‐guided P‐SOZA) in 6 patients. The early spread was ablated in three SEEG‐guided SOZA patients. Five patients had ablation of a lesion. The seizure freedom rate in the cohort ranged between 22% and 50%, and the responder rate between 67% and 85%. SEEG‐guided SOZA demonstrated superior results for both outcomes compared to SEEG‐guided P‐SOZA at 6 months (seizure freedom p = .294, responder rate p = .014). Adding the early spread ablation to SEEG‐guided SOZA did not increase seizure freedom rates but exhibited comparable effectiveness regarding responder rates, indicating a potential network disruption.
Strangulation of the small colon by a pendulous ovarian pedicle in an adult broodmare
Authors: Claunch Kevin M. , Wurst Parker , Chisholm Cari 
Published: May 2024

SummaryA 17‐year‐old Quarter Horse broodmare was taken to surgery for signs of colic unresponsive to medical management. The small colon was strangulated by a pendulous ovarian pedicle. The strangulation was freed, and the affected ovary was removed. The mare developed signs of a small colon obstruction 4 days after surgery. The mare was euthanised 6 days after surgery because of a GI rupture. A post‐mortem examination revealed necrosis of the previously strangulated portion of small colon.
Inhibition of the morphological transition of Candida spp. by riparins I–IV
Authors: Queiroz da Silva Maria Lucilene , Ferreira de Sousa Natália , dos Santos Antonia Thassya Lucas , de Sousa Gabriela Ribeiro , Fonseca Victor Juno Alencar , Douglas Melo Coutinho Henrique , Barbosa Filho José Maria , de Souza Ferrari Jailton , Scotti Marcus Tullius , Ribeiro‐Filho Jaime , Martins de Lima João Paulo , da Rocha João Batista Teixeira , Bezerra Morais‐Braga Maria Flaviana 
Published: May 2024

AbstractCandida spp. is an opportunistic pathogen capable of causing superficial to invasive infections. Morphological transition is one of the main virulence factors of this genus and, therefore, is an important variable to be considered in pharmacological interventions. Riparins I, II, III, and IV are alkamide‐type alkaloids extracted from the unripe fruit of Aniba riparia, whose remarkable pharmacological properties were previously demonstrated. This work aimed to evaluate in silico and in vitro the inhibitory effects of Riparins on the morphological transition of Candida albicans, Candida tropicalis, and Candida krusei. Molecular docking was applied to analyze the inhibitory effects of riparins against proteins such as N‐acetylglucosamine, CYP‐51, and protein kinase A (PKA) using the Ramachandran plot. The ligands were prepared by MarvinSketch and Spartan software version 14.0, and MolDock Score and Rerank Score were used to analyze the affinity of the compounds. In vitro analyses were performed by culturing the strains in humid chambers in the presence of riparins or fluconazole (FCZ). The morphology was observed through optical microscopy, and the size of the hyphae was determined using the ToupView software. In silico analysis demonstrated that all riparins are likely to interact with the molecular targets: GlcNAc (>50%), PKA (>60%), and CYP‐51 (>70%). Accordingly, in vitro analysis showed that these compounds significantly inhibited the morphological transition of all Candida strains. In conclusion, this study demonstrated that riparins inhibit Candida morphological transition and, therefore, can be used to overcome the pathogenicity of this genus.
Evaluation of hematological inflammatory parameters in patients with palmoplantar pustulosis
Authors: Ning Xin , Wu Chao , Song Biao , Wang Hai‐Meng , Jin Hong‐Zhong 
Published: May 2024

AbstractBackgroundPalmoplantar pustulosis (PPP) is a chronic inflammatory disease of ill‐defined etiopathology. Recent studies have proposed complete blood count‐based hematological parameters, such as neutrophil/lymphocyte ratio (NLR) and platelet/lymphocyte ratio (PLR), as biomarkers to monitor disease status in many inflammatory diseases. This study aimed to analyze for the first time the clinical significance of hematological parameters, including NLR, monocyte/lymphocyte ratio (MLR), PLR, mean platelet volume (MPV), plateletcrit (PCT), and pan‐immune‐inflammation value (PIV) in PPP patients.MethodsWe retrospectively investigated the clinical and laboratory data of 237 patients with PPP and 250 sex‐age‐matched healthy controls (HCs). Hematological parameters were compared between patients with PPP and HCs. The correlations between these parameters and disease severity, as well as treatment response, were analyzed.ResultsNLR, MLR, MPV, PCT, and PIV values were significantly higher in PPP patients than in HCs. But in receiver‐operating characteristic analyses, only monocyte count (Youden Index = 0.53), PCT (Youden Index = 0.65), and PIV (Youden Index = 0.52) performed relatively accurate distinguishment between moderate‐to‐severe cases and mild cases. PCT and PIV values were significantly correlated with disease severity. After treatment, both PIV and PCT values decreased significantly in the responder group but not in the non‐responder group.ConclusionsHematological parameters altered significantly in PPP patients. PCT and PIV can be used as simple and inexpensive biomarkers for systemic inflammation in PPP patients.
Recent advances, challenges and functional applications of protein glycosylation modification in food industry
Authors: Hu Shunyang , Wang Bangxu , Zeng Rumei , Luo Qing , Zhao Peiming , Bai Ting , Cheng Jie , Zhang Jiamin 
Published: May 2024

SummaryProtein glycosylation modification is an effective way to enhance the functional properties of natural proteins. This study aims to explore the preparation of glycosylation products (PPCs) through the Maillard reaction or enzymatic glycosylation using transglutaminase. The study discusses the advantages and disadvantages of preparing PPCs using dry heat, wet heat, and enzymatic glycosylation, as well as factors influencing the glycosylation process. Compared to natural proteins, PPCs demonstrate superior functional properties, including solubility, viscosity, emulsifying ability, gelling ability, thermal stability, antioxidant activity, and antibacterial activity. With improved functional performance, PPCs have broad application prospects as raw materials in food processing. For example, PPCs can be used as antioxidants, emulsifiers, gelling agents, and carriers for various bioactive molecules in the food industry. In the pharmaceutical field, PPCs are expected to serve as contrast agents and dressings. Furthermore, the application of PPCs in food processing should also consider specific processing requirements to achieve the intended enhancement of glycosylated protein functionality.
Human CD4+iNKT cell adoptive immunotherapy induces anti‐tumour responses against CD1d‐negative EBV‐driven B lymphoma
Authors: Baiu Dana C. , Sharma Akshat , Schehr Jennifer L. , Basu Jayati , Smith Kelsey A. , Ohashi Makoto , Johannsen Eric C. , Kenney Shannon C. , Gumperz Jenny E. 
Published: May 2024

AbstractInvariant natural killer T (iNKT) cells are a conserved population of innate T lymphocytes that are uniquely suitable as off‐the‐shelf cellular immunotherapies due to their lack of alloreactivity. Two major subpopulations of human iNKT cells have been delineated, a CD4− subset that has a TH1/cytolytic profile, and a CD4+ subset that appears polyfunctional and can produce both regulatory and immunostimulatory cytokines. Whether these two subsets differ in anti‐tumour effects is not known. Using live cell imaging, we found that CD4− iNKT cells limited growth of CD1d+ Epstein–Barr virus (EBV)‐infected B‐lymphoblastoid spheroids in vitro, whereas CD4+ iNKT cells showed little or no direct anti‐tumour activity. However, the effects of the two subsets were reversed when we tested them as adoptive immunotherapies in vivo using a xenograft model of EBV‐driven human B cell lymphoma. We found that EBV‐infected B cells down‐regulated CD1d in vivo, and administering CD4− iNKT cells had no discernable impact on tumour mass. In contrast, xenotransplanted mice bearing lymphomas showed rapid reduction in tumour mass after administering CD4+ iNKT cells. Immunotherapeutic CD4+ iNKT cells trafficked to both spleen and tumour and were associated with subsequently enhanced responses of xenotransplanted human T cells against EBV. CD4+ iNKT cells also had adjuvant‐like effects on monocyte‐derived DCs and promoted antigen‐dependent responses of human T cells in vitro. These results show that allogeneic CD4+ iNKT cellular immunotherapy leads to marked anti‐tumour activity through indirect pathways that do not require tumour cell CD1d expression and that are associated with enhanced activity of antigen‐specific T cells.
Mobilising new frontiers in digital transformation research: A problematization review
Authors: Ashrafi Amir , Constantinides Panos , Mehandjiev Nikolay , Thatcher Jason Bennett 
Published: May 2024

AbstractIn this paper, we mobilise new frontiers in digital transformation (DT) research by deconstructing the literature's underlying assumptions and analysing their correspondence with current theory. To do so, we conduct a problematization review across the fields of IS, strategy and entrepreneurship, organisation theory and management studies, to capture the multidimensionality of DT research. Unlike systematic literature reviews commonly found in DT research, a problematization review critically questions how theoretical contributions have been constructed in past research to develop novel theoretical questions. Our findings offer three contributions. First, we uncover five research trajectories, each with its own in‐house assumptions about the nature of digital technologies and how organisations, groups and individuals interact with those technologies and the data they generate. Second, we show how individual studies within the identified research trajectories position themselves against prior research, pointing at six distinct processes of constructing theoretical contributions. Finally, we mobilise new frontiers of research by questioning DT research field assumptions that cut across the five research trajectories. We conclude by discussing the theoretical implications of our problematization review for further DT research.
Drone scheduling in a hexagon‐based delivery network with multiple fulfillment centers
Authors: Liu Chuang , Chen Huaping , Li Xueping , Zhou Shengchao , Jia Zhaohong 
Published: May 2024

AbstractAs an emerging technology, drones have great potential in small parcel delivery, reducing operational costs, and improving efficiency. However, battery technologies restrict the endurance of drones. Inspired by the cellular networks used in mobile communications, a hexagon‐based delivery network (HBDN) is proposed to overcome such restrictions. Battery‐swapping stations are incorporated into the HBDN to expand the delivery service range of drones. Based on the proposed HBDN, the multidrone scheduling problem in multiple fulfillment centers (FCs) is addressed. The objective is to minimize the makespan. A mixed‐integer programming model is constructed for the problem. A memetic algorithm with hill climbing (MAHC) is developed to address the problem. A strategy is proposed to prevent inbreeding in the crossover procedure. A local search based on hill climbing is combined with the mutation operation. A lower bound of the problem is proposed to measure the performance of MAHC. Furthermore, load balancing and nearest‐priority strategies are proposed to select FCs. Comparative experiments show that MAHC performs competitively in terms of running time and solution quality.
Internet‐based breastfeeding peer support for breastfeeding parents: An integrative review
Authors: Hiito Elisa , Ikonen Riikka , Niela‐Vilén Hannakaisa 
Published: May 2024

AbstractAimTo explore what Internet‐based breastfeeding peer support offers to breastfeeding parents.DesignIntegrative review.Data Sources and Review MethodsA systematic literature search was conducted in March 2024 using the following electronic databases: CINAHL, The Cochrane Library, PubMed/MEDLINE and PsycINFO. Database searches yielded 717 results. Two researchers removed the duplicates (n = 256) and screened the remaining titles (n = 461), abstracts (n = 197) and full texts (n = 60) independently. Eventually, 19 studies were included in the review. The chosen studies had qualitative (n = 11), quantitative (n = 6), or mixed methods designs (n = 2) and were published between 2015 and 2024. Qualitative content analysis was conducted.ResultsThe main categories were supplying support that is responsive to the needs of parents and belonging to a breastfeeding community. The parents looked for and received breastfeeding support, advice, information, emotional support, reassurance and access to shared experiences from various online breastfeeding peer support groups. The support groups helped them in their breastfeeding decisions, thus making a difference in their breastfeeding experience. The support groups created breastfeeding communities for these parents and they were able to bond with others, feel like they belonged and share experiences. Additionally, these breastfeeding communities helped to normalize various breastfeeding practices.ConclusionBreastfeeding peer support groups can offer parents the support and guidance they seek and a sense that they are part of a breastfeeding community. However, it is vital these groups are efficiently moderated to ensure the advice parents receive is evidence‐based and the support is encouraging.ImpactThese findings show that well‐moderated online breastfeeding peer support can offer parents high‐quality support. It is essential for health care professionals to be aware of the various options available in order to recommend high‐quality support groups for breastfeeding parents.Reporting MethodPRISMA.Patient or Public ContributionThis was an integrative review therefore no patient or public contribution was necessary.
Dual holdings and shareholder–creditor agency conflicts: Evidence from the syndicated loan market
Authors: Geburtig Ingo , Mählmann Thomas , Liebscher Roberto 
Published: May 2024

AbstractWe examine implications from the expansion of private equity (PE) firms into the collateralized loan obligation (CLO) (i.e., leveraged lending) business. Due to similarities in the investment universes of CLO managers and PE firms, asset managers running both of them frequently hold debt and equity claims of the same company. Our results indicate lower credit costs for these companies through the mitigation of shareholder–creditor agency conflicts. The lower funding costs imply increased equity returns for the sponsoring PE firms. In addition, our findings suggest that PE‐affiliated CLO managers benefit from informed trading in the secondary leveraged loan market.
Sentinel lymph node biopsy versus observation in high‐risk cutaneous squamous cell carcinoma in immunosuppressed and immunocompetent patients: An inverse probability of treatment weighting study
Authors: Tejera‐Vaquerizo Antonio , Gómez‐Tomás Álvaro , Jaka Ane , Toll Agustín , del Río María , Ferrándiz‐Pulido Carla , Fuente María J. , Carrasco Cristian , Almazán‐Fernández Francisco M. , Toledo‐Pastrana Tomás , Ferrer‐Fuertes Ada , Ribero Simone , Avallone Gianluca , Cañueto Javier , Santos‐Juanes Jorge , Sanmartín Onofre 
Published: May 2024

AbstractBackgroundThe survival benefit of sentinel lymph node biopsy (SLNB) in immunocompetent and immunosuppressed patients with high‐risk cutaneous squamous cell carcinoma (cSCC) has not been established.ObjectiveTo determine whether SLNB improves disease‐specific survival (DSS) in high‐risk cSCC. Secondary objectives were to analyse disease‐free survival, nodal recurrence‐free survival and overall survival (OS).MethodsMulticentre, retrospective, observational cohort study comparing survival outcomes in immunosuppressed and immunocompetent patients treated with SLNB or watchful waiting. Inverse probability of treatment weighting was used to adjust for possible confounding effects.ResultsWe studied 638 tumours in immunocompetent patients (SLNB n = 42, observation n = 596) and 173 tumours in immunosuppressed patients (SLNB n = 28, observation n = 145). Overall, SLNB was positive in 15.7% of tumours. SLNB was associated with a reduced risk of nodal recurrence (NR) (hazard ratio [HR], 0.05 [95% CI, 0.01–0.43]; p = 0.006), disease specific mortality (HR, 0.17 [95% CI, 0.04–0.72]; p = 0.016) and all‐cause mortality (HR, 0.33 [95% CI, 0.15–0.71]; p = 0.004) only in immunocompetent patients.ConclusionsSLNB was associated with improvements in NR, DSS and OS in immunocompetent but not in immunosuppressed patients with high‐risk cSCC.
Diet modification reduces pain and improves function in adults with osteoarthritis: a systematic review
Authors: Stanfar Karen , Hawes Corey , Ghajar Mina , Byham‐Gray Laura , Radler Diane R. 
Published: May 2024

AbstractBackgroundThe effect of dietary modifications on pain and joint function in adults with osteoarthritis (OA) is an emerging area of study. This systematic review aimed to evaluate if adults with OA who consume diets with a higher proportion of plant phenols and omega‐3 fatty acids would have less pain and improved joint function than those with a higher proportion of saturated fatty acids, omega‐6 fatty acids and refined carbohydrates.MethodsDatabase searches of CINAHL (EBSCO), Clinical Trials (NIH‐NLM), Cochrane Library (Wiley), Dissertation & Thesis Global (ProQuest), Embase (Elsevier), Medline (OVID), PubMed (NLM), Scopus (Elsevier), Web of Sciences (Clarivate) for clinical trials identified 7763 articles published between January 2015 and May 2023. After an independent review of the articles, seven randomised clinical trials and one nonrandomised clinical trial were included in the analysis. Because of the heterogeneity of the outcome measures, a meta‐analysis was not possible.ResultsParticipants who were instructed to consume high‐phenol/high‐omega‐3 fatty acid diets reported significant improvements in pain and physical function scores. The greatest improvement was reported by those who consumed a diet that had the most omega‐3 fatty acids.ConclusionBecause of the high risk of bias, the strength of the evidence is limited. However, there is evidence that counselling adults with OA to replace refined grains and processed foods with whole plant foods, fish and plant oils may have a favourable effect on pain and physical function. Routine follow‐up care regarding these diet modifications may be necessary to ensure adherence to this therapy.
Strategies for selecting and managing equipment in a light microscopy facility
Authors: Anderson Kurt I. 
Published: May 2024

AbstractLight microscopy facilities vary in the number of imaging systems and the scope of technologies they support. Each facility must craft an identity through the selection of equipment and development of staff in order to serve the needs of its local research environment. The process of crafting a light microscopy facility can be compared to curation of an art exhibition: great care should be given to the selection and placement of each object in order to make a coherent statement.Lay Description: Light microscopy facilities vary in the number of imaging systems and the scope of technologies they support. Each facility must develop an identity through the selection of equipment and development of staff in order to serve the needs of its local research environment. The process of crafting a light microscopy facility can be compared to curation of an art exhibition: great care should be given to the selection and placement of each object in order to make a coherent statement.
Photodynamic therapy for the treatment of port‐wine stains in phakomatosis pigmentovascularis
Authors: Huang Yuanbo , Yang Jun , Bi Mingye , Wang Lei , Ju Wen , Liu Xuan , Bi Lingbo , Du Yimei , Chen Bin , Fan Weixin 
Published: May 2024

AbstractBackgroundPhakomatosis pigmentovascularis (PPV) is a rare congenital syndrome. Only a few studies have reported the treatment of PPV, including a case using photodynamic therapy (PDT) to treat PPV‐associated port‐wine stains (PWS).ObjectiveTo investigating the efficacy and adverse effects of hemoporfin‐PDT in PPV‐associated PWS.MethodsThe efficacy and adverse effects in patients with PPV who underwent two sessions of hemoporfin‐PDT from January 2019 to December 2022 were retrospectively analyzed.ResultsTwenty patients were included (13 females, 7 males, age range: 2–31 years; mean: 8.20 ± 8.92 years). Two, nine, seven, and two patients had PPV types Ia, IIa, IIb, and IIIa, respectively. After two treatments, the visual evaluation indicated the color of the PWS in 4, 5, 6, and 5 patients showed poor, fair, good, and excellent improvements, respectively. The combined good and excellent improvement rates in patients with PWS and pigmentary nevus overlapping in the same treatment area and in patients with PWS in the treatment areas only were 33.3% versus 87.5%, respectively, and were significantly different (p = 0.02). Minor side effects, such as edema, scabbing, hyperpigmentation, and blistering, were observed in some patients after PDT.ConclusionHemoporfin‐PDT is an effective treatment for PPV‐associated PWS. Patients with PWS and pigmentary nevus overlapping in the same treatment area showed poorer efficacy than patients with PWS in the treatment areas only.
Safety and efficacy of tofacitinib in 97 alopecia areata patients
Authors: Nasimi Maryam , Abedini Robabeh , Ghandi Narges , Teymourpour Amir , Babaie Hanie 
Published: May 2024

AbstractBackgroundAlopecia areata (AA) is a recurrent immune‐mediated disorder causing hair loss without any scarring being present. It affects hairs on the head or other parts of the body and can occur at any age and in both genders. It seems that AA is associated with a higher rate of psychological disorders resulting from hair loss and the esthetic and social repercussions of it. Common treatments like corticosteroids do not work for every patient and recent treatment options focusing on the immunologic mechanisms like tofacitinib have shown some promising results.MethodsIt's a retrospective study on patients with AA, AT, AU taking oral tofacitinib as a treatment for at least 6 months. Scalp hair loss was assessed before treatment and at each visit using the Severity of Alopecia Tool (SALT) score.ResultsOf 97 cases, 69.1% demonstrated over 50% SALT score improvement, with 44.3% having 90% or more decrease in SALT score. Patients who suffered from patchy AA were more responsive compared to patients with AT and AU subtypes and had a greater percent change in SALT score. Tofacitinib was tolerated quite well and no significant adverse events were reported.ConclusionsTofacitinib should be taken into consideration as an efficacious treatment option for patients with AA, AT and AU.