bluuebunny/crossref_metadata_2025_split huggingface dataset:
Common design and data elements on rectal artery embolization for treatment of symptomatic internal hemorrhoidal disease: an interactive systematic review of clinical trials
Authors: Morsi Samah , Linares Bolsegui Marisabel , Kobeissi Hassan , Ghozy Sherief , Kallmes David F. , Kelley Scott R. , Mathis Kellie L. , Dozois Eric J. , Loftus Conor G. , Bendel Emily C. , Vidal Vincent , Thompson Scott M. 
Published: May 2024

Abstract
Background
Internal hemorrhoids (IH) is a common medical condition that can result in morbidity secondary to bleeding and discomfort. Treatment for IH has traditionally consisted of dietary and conservative medical management, focal treatments including banding and sclerotherapy or hemorrhoidectomy. Recently, rectal artery embolization (RAE) has been studied as a potential treatment for bleeding predominant IH. We performed a common design and data element analysis of studies that report on RAE.

Materials and methods
We conducted a qualitative systematic literature review for rectal artery embolization (RAE) for symptomatic hemorrhoidal disease. The screening process involved five online databases (PubMed, Embase, Google Scholar, DOAJ, and Scopus). Additionally, ClinicalTrials.gov was examined for active, unpublished completed studies. The initial search yielded 2000 studies, with 15 studies meeting the inclusion criteria after screening and assessment. The included studies comprised one RCT, one case series, one pilot study and 12 cohort studies.

Results
The population analysis revealed a male predominance across all studies, with varying cohort sizes. The baseline Goligher hemorrhoid grade was utilized in 80% of studies. The majority (73.3%) employed a transfemoral approach, and coils were the primary embolic material in 60% of studies, 26.6% were combination of coils and particles, and 6.6% were particles only. Patient selection criteria highlighted RAE's applicability for high surgical risk patients and those with anemia, chronic hematochezia, or treatment-refractory cases. Exclusion criteria emphasized factors such as previous surgeries, colorectal cancer, rectal prolapse, acute hemorrhoidal complications, and contrast allergy.
Study designs varied, with cohort studies being the most common (12/15; 80%). Procedural details included the use of metallic coils and detachable micro-coils, with a high technical success rate reported in most studies ranging from 72 to 100%. The follow-up ranged from 1 to 18 months. The majority of studies reported no major immediate or post-procedural complications.

Conclusion
While all studies focused on RAE as a treatment for IH, there was a great degree of heterogeneity among included studies, particularly regarding inclusion criteria, exclusion criteria, outcomes measures and timeframe. Future literature should attempt to standardize these design elements to help facilitate secondary analyses and increase understanding of RAE as a treatment option.
Gravitating kinks with asymptotically flat metrics
Authors: Wang Ziqi , Zhong Yuan , Wang Hui 
Published: May 2024

Abstract
In this work, we consider a two-dimensional (2D) dilaton gravity model where the dilaton kinetic term

is modified by an additional derivative coupling term

. In the case with a canonical scalar matter field, the field equations of this model have a simple first-order formalism, from which exact static kink solutions can be constructed. The novelty of these solutions is that the corresponding metric can be asymptotically flat rather than asymptotically anti-de Sitter. The linear stability and the localization of scalar matter fields are also studied. It was found that the solutions are stable against small linear perturbations, and the localization of scalar matter fields can be realized by introducing scalar-kink interactions.
Thermodynamic properties of an interacting fermion-antifermion pair in a magnetized spacetime with a non-zero cosmological constant
Authors: Guvendi Abdullah , Boumali Abdelmalek 
Published: May 2024

Abstract
In a magnetized three-dimensional Bonnor-Melvin spacetime with a non-zero cosmological constant, we explore the dynamics of a fermion-antifermion pair interacting through an attractive Coulomb potential. To analyze the relativistic behavior, we seek an analytical solution for the fully covariant two-body Dirac equation derived from quantum electrodynamics. The resulting equation provides a second-order wave equation that governs the relative motion of the interacting pair. Obtaining an exact solution to this wave equation seems not possible; however, we notice solubility, especially when we consider particles to be closely spaced, meaning as the distance between them approaches zero. At that rate, we determine the energy eigenvalues and wave functions utilizing well-known special functions. By employing these solutions, we determine the thermal properties of this system. Despite the divergence observed in the partition function, we effectively tackle this issue by applying a regularization technique based on the mathematical zeta Hurwitz function. This method facilitates the computation of various thermal quantities, such as free energy, total energy, entropy function, and specific heat. Consequently, we provide an in-depth analysis of the thermodynamic characteristics of the system under consideration.
Skeletal Effect of Parathyroidectomy on Patients With Primary Hyperparathyroidism: A Systematic Review and Meta-Analysis
Authors: Kongsaree Nattanan , Thanyajaroen Thanaporn , Dechates Bothamai , Therawit Phonthip , Mahikul Wiriya , Ngaosuwan Kanchana 
Published: May 2024

Abstract

Context
Parathyroidectomy (PTX) is recommended for curing primary hyperparathyroidism (PHPT), although uncertainty remains regarding the extent of fracture risk reduction following surgery.

Objective
This work aimed to compare fracture risk and bone mineral density (BMD) changes in patients with PHPT undergoing PTX vs observation (OBS).

Methods
We systematically searched PubMed, Embase, and the Cochrane Library until September 2022, including randomized controlled trials (RCTs) and cohort studies, and reviewed citations from previous reviews. Among 1260 initial records, 48 eligible articles from 35 studies (5 RCTs; 30 cohorts) included PHPT patients receiving PTX or OBS interventions with reported fracture events at any site, including the hip, spine, or forearm, and/or BMD changes at each location. Data extraction followed Preferred Reporting Items for Systematic Reviews and Meta-analysis (PRISMA) guidelines by 2 independent reviewers.

Results
In 238 188 PHPT patients (PTX: 73 778 vs OBS: 164 410), PTX significantly reduced fractures at any site (relative risk [RR], 0.80; 95% CI, 0.74-0.86) compared to OBS. In 237 217 patients (PTX: 73 458 vs OBS: 163 759), the risk of hip fractures decreased (RR, 0.63; 95% CI, 0.52-0.76). No reduction in forearm and vertebral fractures was observed in 3574 and 3795 patients, respectively. The annual percentage BMD changes from baseline were higher in the PTX group: femoral neck, 1.91% (95% CI, 1.14-2.68); hip, 1.75% (95% CI, 0.58-2.92); radius, 1.75% (95% CI, 0.31-3.18); spine, 2.13% (95% CI, 1.16-3.10).

Conclusion
PTX significantly reduced overall and hip fracture risks in PHPT patients. Despite minimal BMD increase, the substantial decrease in fracture risk suggests additional benefits of PTX beyond mineral content enhancement.
Role of dietary supplements in the treatment of asthma - a narrative review
Authors: Kozicz Michał Andrzej , Kołodziej Magdalena , Saiuk Nazarii , Mądry Wojciech , Marcicka Justyna , Mazurkiewicz Aleksandra , Salasa Weronika , Wojciechowska Adriana , Seredyński Tomasz , Męczyńska Joanna 
Published: May 2024

Introduction: Asthma is a common inflammatory disease of airway affecting both adults and children. In a large number of cases asthma remains poorly controlled. There is a need to find an additional therapeutic demeanour alleviating symptoms and lowering the risk complications in a long-term. Recently, increasing number of studies has been examining dietary supplements in regards to their anti-inflammatory, immunomodulatory, anti-remodelling properties and their use in asthmatic patients.
Aim of the Study: The aim of the study was to collect and analyse current literature regarding influence of different dietary supplements on the course of asthma in both adults and children.
Methods and Materials: Extensive research was conducted using PubMed and Google Scholar, with the primary focus on literature from the past 5 years. Firstly, potential dietary supplements affecting course of asthma were collected. The names of the substances were juxtaposed with term “Asthma” to gather data regarding their effect on occurrence and control of asthma and potential mechanisms responsible for it. Additionally, references from selected articles were included in the analysis.
Results: Dietary supplements show promising results in decreasing asthma symptoms and lowering inflammation of airway. However, our study revealed that in current state of knowledge there is a deficit of studies performed on humans, especially large-scale, prospective studies that assess the efficacy of different doses of dietary supplements. Thus, further research of dietary supplements in asthma is needed, especially large-scale randomised controlled trials.
Clinical manifestations of EVALI in adolescents and the impact of e-cigarettes on the respiratory disease
Authors: Hądzlik Izabela , Piotrowski Jan , Durowicz Marcin , Paśnik Joanna , Sendecka Gabriela , Kistela Natalia , Skrzypczak Katarzyna Oktawia , Krala-Szkaradowska Magdalena , Stencel Nicola Joanna , Stuczyński Sebastian Krzysztof 
Published: May 2024

In recent years there has been a significant increase in the popularity of electronic cigarettes among adolescents and young adults worldwide. E-cigarettes have reached the market without the extensive preclinical toxicology testing or long-term safety studies required for conventional therapeutics and medical devices. Their effectiveness as a smoking cessation intervention, their impact at the population level and whether they are less harmful than combustible tobacco products are highly controversial. Studies show measurable adverse biological effects on organ and cell health in humans, animals and in vitro. E-cigarette use also increases the risk of respiratory diseases such as chronic obstructive pulmonary disease (COPD) and asthma. There is a serious risk of complications associated with e-cigarette use, such as EVALI (E-cigarette or Vaping Product Use-Associated Lung Injury) - serious lung damage associated with, especially for adolescents. This paper reviews the effects of e-cigarettes on respiratory health.
Results of a retrospective study of the clinical efficacy and safety of insulin RinFast® in children with type 1 diabetes mellitus
Authors: Dianov O. A. , Oleynik D. A. , Fofanova A. V. 
Published: May 2024

BACKGROUND: The relevance of the study is justified by the fact that in recent years, the original insulin preparations have been replaced with biosimilars in the regions of the Russian Federation, but there are currently few studies describing the use of insulin biosimilars in children with type 1 diabetes mellitus (DM1), both in domestic and foreign sources.AIM: To evaluate the efficacy and safety insulin therapy with RinFast® (GEROPHARM LLC, Russia) as bolus therapy in combination with long-acting insulin and as monotherapy in an insulin pump in children with DM1 in real clinical practice.MATERIALS AND METHODS: The dynamics of HbA1c after 3 and 6 months, the change in daily insulin requirements, the fre quency of episodes of postprandial hyper- and hypoglycemia, adverse reactions at injection sites, the number of patients who reached the target values of HbA1c in children with DM1 who received RinFast® at least 6 months after the original analogue of insulin aspart were evaluated.RESULTS: The study was conducted in 50 children with DM1 from 1 to 18 years old (average age 9.8±4.6 years), with a duration of DM1 of more than 1 year (average duration 3.5±2.1 years), who had glycated hemoglobin (HbA1c) at the beginning of follow-up of no more than 9.5% and received biosimilar RinFast® for at least 6 months after the transfer from the original analogue of insulin aspart. Basic bolus insulin therapy in 36 children was carried out using multiple injections of insulin (MII), in 14 — continuous supply of insulin (NPI) using an insulin pump. The study resulted in HbA1c levels comparable to the baseline 3 and 6 months after the start of therapy with the RinFast® biosimilar (p=0.05), no changes in the daily ­insulin ­requirement (p=0.05) and no increase in the frequency of episodes of postprandial hyper- (p=0.05) and hypoglycemia (p=0.05) and adverse events (p=0.05). High adherence to treatment with the RinFast® biosimilar was noted.CONCLUSION: The results obtained indicate the absence of a clinically significant deterioration in glycemic control indicators after the transfer of children with DM1 to therapy with the RinFast® biosimilar, which makes it possible to use it safely and effectively in this category of patients.
Time in range prediction using the experimental mobile application in type 1 diabetes
Authors: Rusanov A. N. , Rodionova T. I. 
Published: May 2024

BACKGROUND: Time in range (TIR) is a promising indicator of glycemic control used for evaluation of continuous glucose monitoring (CGM) for patients with diabetes mellitus (DM). The current problem is the assessment and prediction of TIR for patients who use self-monitoring of blood glucose (SМBG) corresponding low CGM availability for the majority of diabetic patients.AIM: To develop a predictive model of TIR for patients with T1DM based on data of the experimental mobile application.MATERIALS AND METHODS: An analysis of 1253 professional CGM profiles of patients with T1DM was performed. On the base of included records, TIR(CGM) was calculated and training models of 7-point SMBG profiles were generated. SMBG profiles’re loaded into the developed experimental mobile application that calculated standard glycemic control parameters. The dataset was divided into main and test samples (80 and 20%). For the main sample, the following methods’re used to develop predictive models: simple linear regression (SLR), multiple linear regression (MLR), artificial neural network (ANN). The effectiveness of the developed models was assessed on the test sample with the calculation of the mean absolute error (MAE), the root mean square error (RMSE).RESULTS: The 568 CGM profiles’re included in the study. TIR in the main group (n=454) — 45 [33; 65]%, in the test group (n=114) — 43 [33; 58]%. The most significant predictors of the regression models were the derived TIR (dTIR), p<0,001; derived time below range level 1 (dTBR1), p<0,001; standard deviation of blood glucose (SD), p=0,007. Determination coefficient for SLR (predictor: dTIR) — 0,844; for MLR (predictors: dTIR, dTBR1, SD) — 0,907. ANN multilayer perceptron models with two and one hidden layers’re developed, with the RMSE on the validation set 4,617 and 6,639%, respectively. The results of the forecast efficiency on the test sample were: dTIR: MAE — 6,82%, RMSE — 8,60%; SLR: MAE — 5,66%, RMSE — 7,34%; MLR: MAE — 4,18%, RMSE — 5,28%; ANN (2 layers): MAE — 4,14%, RMSE — 5,19%; ANN (1 layer): MAE — 4,44%, RMSE — 5,52%.CONCLUSION: ANN with two hidden layers and MLR demonstrated the best ability for TIR prediction. Further studies are required for clinical validation of developed prognostic models.
Influence of peripheral nerve system on proliferation and migration of keratinocytes on site of the wound edges
Authors: Artemova E. V. , Dzhemilova Z. N. , Gorbacheva A. M. , Galstyan G. R. , Tokmakova A. Yu. , Berdalin A. B. , Gavrilova S. A. 
Published: May 2024

AIM: to assess proliferation and migration of keratinocytes at the nonhealing edges of neuropathic wounds.MATERIALS AND METHODS: 25 patients with neuropathic ulcers and 5 patients without diabetes with decubitus were enrolled. Diabetic foot (DF) patients were underwent to standard treatment including debridement, atraumatic dressing, offloading, antibacterial therapy if it needs. Severity of peripheral neuropathy was assessed according to the NDS scale. Histo­logical (hematoxylin and eosin) and immunohistochemical (Ki-67 , α7nAChR markers) examination of wound edge were done during treatment (0, 10, 24 days).RESULTS: All patients have severe neuropathy according to NDSm (>8). The average size of DF ulcers before and on 10th day of treatment was of 4 cm2 and 2,5 cm2, respectively (p<0,004). Neuropathic ulcers were characterized by hyperproliferative epidermis. Mitotically active keratinocytes reside throughout the suprabasal layers. Ki-67 expressed all layers of the epidermis, but a greater staining density was detected in the basal layer. The density of a7nAChR-positive cells increased from 0 to 24 days (p=0,031).THE CONCLUSION: The data shows that neuropathy is one of the possible mechanisms of keratinocyte cell cycle disruption: proliferative activity and ability to migrate. Identification of new signaling pathways regulating the physiological repair of tissues and the study of their disorders in diabetes mellitus opens the prospect of developing an optimal therapeutic strategy.
Место волонтеров в системе реагирования на чрезвычайные ситуации: результаты анализа дискурса российских СМИ
Authors: Башева Ольга Александровна , Гоманова Сильвия Олеговна , Ермолаева Юлия Вячеславовна 
Published: May 2024

В статье представлены результаты качественного и количественного анализа материалов СМИ о спасательном волонтерстве за 2018-2019 гг., проведенного с применением фрейм-анализа, предложенного Д. Сноу и Р. Бенфордом. Данный подход предполагает выделение трех центральных фреймов (диагностического, прогностического и мотивационного) для определения проблемной ситуации, интерпретации причин ее возникновения, оценки и выработки рекомендаций по ее разрешению.
Диагностический фрейм иллюстрирует масштаб и функционал волонтерского движения, характер его встроенности в систему реагирования на чрезвычайные ситуации (ЧС) через описание системы взаимодействий с официальными службами, а также проблемные аспекты в области реагирования на ЧС, способствующие развитию добровольческого спасательного движения. Последние включают нехватку штата специалистов на местах, большие по площади территории, бюрократические препоны и проч. В рамках диагностического фрейма выделен образ волонтера, формируемый в СМИ дуально: как саморепрезентация волонтеров и как представления, складывающиеся в сознании других участников коммуникации. Можно сказать, что двойственный образ адаптируется к требованиям текущей ситуации в стране, характеризующейся необходимостью волонтерского участия в реагировании на ЧС, и наделяется идеологическими и социальными ценностями, отвечающими общественным потребностям.
Прогностический фрейм показывает перспективы и условия развития добровольческого движения, а также его потенциал в повышении эффективности системы реагирования на ЧС (официальный дискурс подразумевает все большую поддержку волонтерства, снижение его стихийности и трансформацию в компетентный и контролируемый ресурс сил реагирования на ЧС).
Мотивационный фрейм показывает, какую реальную пользу оно уже приносит и может принести в дальнейшем: волонтеры рассматриваются как необходимый «ресурс» и помощь профессиональным службам в связи с географическим масштабом России, нехваткой штатных сотрудников служб спасения, наличием у волонтеров локальных знаний и технологий.
Благодарность. Исследование выполнено в рамках проекта «Волонтерство в чрезвычайных ситуациях как ответ на природные и техногенные вызовы в России», поддержанного РНФ, грант № 19-78-10052.
Synthesis and properties of novel degradable polyglycolide-based polyurethanes
Authors: Wang Jing-Jing , Zhou Ying-Guo , Zhang Qian-Qian , Zou Jun 
Published: May 2024

Graphical abstract
Polyglycolide-based polyurethane was synthesized via chain extension reaction. As the hard segment content increases, its thermal stability and mechanical properties are improved; and the weight loss rate in PBS solution is reduced.
Which patients with chronic low back pain respond favorably to multidisciplinary rehabilitation? A secondary analysis of a randomized controlled trial
Authors: Kjærgaard Claus , Schmidt Anne Mette , Larsen Josefine Beck , Laurberg Trine Bay , Mechlenburg Inger 
Published: May 2024

Abstract

Objectives
The aim of this study was to identify prognostic variables at baseline associated with being responding favorably to multidisciplinary rehabilitation in patients with chronic low back pain (CLBP).

Methods
A responder analysis was conducted based on data from a randomized controlled trial with 26-week follow-up including 165 patients with CLBP treated at a Danish multidisciplinary rehabilitation center. Patients were dichotomized into responders and non-responders based on the outcome of a minimal clinically important difference of six points on the Oswestry Disability Index. The associations between prognostic variables and responders were analyzed using logistic regression.

Results
A total of 139 patients completed the study, of which 42% were classified as responders. Sex and employment status were statistically significant, with a decreased odds ratio (OR) of being a responder found for males compared to females (OR = 0.09, 95% CI = 0.02–0.48) and for being on temporary or permanent social benefits (OR = 0.28, 95% CI = 0.10–0.75) compared to being self-supporting or receiving retirement benefits. Statistically significant interaction (OR = 8.84, 95% CI = 1.11–70.12) was found between males and being on temporary or permanent social benefits.

Conclusions
In patients with CLBP, female patients as well as patients who were self-supporting or receiving retirement benefits were significantly more likely than male patients or patients on temporary or permanent social benefits to be a responder to multidisciplinary rehabilitation.
Karl Rahner’s Theology of the Diaconate: A Reappraisal
Authors: Pabel Hilmar M. 
Published: May 2024

Abstract
Both before and after the Second Vatican Council, Karl Rahner promoted the restoration of the diaconate as a permanent order in the Catholic church. His theology of the diaconate has eluded sustained attention. After providing the historical context for his contribution, this reappraisal, in a close reading of Rahner, elaborates on three essential ecclesiological themes: the church’s exercise of its divine right to establish a discrete diaconate by dividing office, the graced nature of diaconal office, and the specialized function of deacons in the formation of ecclesial community.
Über die aktuelle Bedeutung des liberalen Kulturprotestantismus. Ein Vortrag in Tokyo 2019
Authors: Graf Friedrich Wilhelm 
Published: May 2024

Abstract
Der für japanische und auch einige koreanische Studierende, Doktorandinnen und Doktoranden sowie Universitätsprofessoren und -professorinnen unterschiedlicher kultur- und sozialwissenschaftlicher Disziplinen geschriebene Text wurde am 16. Oktober 2019 in Tokyo in englischer Sprache vorgetragen. Es ging um eine Einführung in zentrale Elemente des Denkens deutscher liberalprotestantischer Theologie seit der „Sattelzeit“ (Reinhart Kosselleck) um 1800 und um die Frage, inwieweit sich theologisch liberale Leitideen [normative ideas] im japanischen theologischen Diskurs rezipieren lassen. Die These: Darüber können nur japanische Theologen selbst entscheiden
The text, written for Japanese and some Korean students, doctoral students and university professors from various cultural and social science disciplines, was read in English on October 16, 2019 in Tokyo. It was about an introduction to central elements of the thinking of German liberal Protestant theology since the „Sattelzeit“ (Reinhart Kosselleck) around 1800 and the question of the extent to which theologically liberal guiding ideas [normative ideas] can be received in Japanese theological discourse. The thesis: Only Japanese theologians can decide this for themselves.