bluuebunny/crossref_metadata_2025_split huggingface dataset:
Is short‐stay coronary angioplasty safe?
Authors: Feldman R. L. 
Published: July 2009

AbstractPercutaneous transluminal coronary angioplasty (PTCA) is usually performed as an inpatient procedure and the patients are monitored for several days afterward. Over a 13‐month period, in 91 of 373 PTCA procedures, the clinical condition of the patient did not necessitate inpatient status before PTCA. PTCA was done the day of admission and discharge planned the following. Overall hospital stay was planned as less than 24 hours. PTCA was done in one vessel in 62 patients, two vessels in 24, three vessels in 3, and four vessels in 2 patients. PTCA was initially successful (<50% residual stenosis) in 85 patients (93%). In one of these, acute occlusion occurred the next morning and urgent bypass surgery was done. PTCA failed in 6 patients who left the catheterization laboratory with unchanged coronary anatomy. Bypass surgery was performed that day in 2 patients, on another admission in 1 patient, and medical therapy continued in the other 3 patients. Of the 88 patients not receiving same admission bypass surgery, 84 (95%) were discharged in less than 24 h. Hospitalization was prolonged (1–5 days) in 4 patients. This was because of nonobstructive dissection treated with heparin for approximately 24 h in 2 patients; a catheterization site hematoma in 1 patient, and post‐PTCA noncardiac chest pain in another. No patient had inhospital myocardial infarction or death. The only late complication was in a patient treated with heparin and monitored for 2 days; 3 weeks later angina returned and he died suddenly. These data suggest PTCA can safely be done in selected patients with both single and multivessel disease in a short stay inhospital setting. Savings of hospital days and costs are obvious.
Left ventricular diastolic filling in patients with coronary artery disease without myocardial infarction
Authors: Iinoue, T. , Morooka, S. , Hayashi, T. , Takayanagi, K. , Sakai, Y. , Takabatake, Y. 
Published: July 2009

AbstractLeft ventricular diastolic dysfunction at rest was studied in 24 patients with coronary artery disease but no evidence of previous myocardial infarction. Seven patients with normal coronary arteries were studied as control. Diastolic filling was analyzed by the serial left ventricular volume and 14 radial axes from the gravity point of the left ventricle with cine left ventriculography. There were no differences in the systolic function between coronary artery disease and the normal control. Peak filling rate was decreased significantly in the groups with left anterior descending artery disease (LAD, p<0.05) and multivessel disease (MVD, p<0.05), but not in the group with right coronary artery disease (RCA). Time to peak filling rate was prolonged in each group of LAD (p<0.05), RCA (p<0.05), and MVD (p<0.001), compared with controls. The time‐volume curve showed disturbed rapid filling in the LAD and RCA groups, and also both depressed rapid and slow filling in the MVD group. In the LAD group, the filling fraction was decreased significantly at the time of 25% of the diastolic period (p<0.001) and radial distension to the anterior wall was decreased at the time of 25%, 50%, and 75% of the diastolic period, compared with controls. In the RCA group, the filling fraction (p<0.001) and radial distension to the posterior wall were decreased only at the time of 25% of the diastolic period. In the MVD group, filling fraction and radial distension to the most wall were decreased at 25%, 50%, and 75% of the diastolic period. In every group of coronary artery disease the deceased filling fraction and radial distension disappeared at end‐diastole. The results showed that, in patients with angina pectoris, the distension of regional ischemic myocardium might be impaired relatively early in diastole and might cause impairment of global left ventricular filling.
Catastrophic thrombus development despite systemic heparinization during coronary angioplasty: Possible relationship to nonionic contrast
Authors: Doorey Andrew J. , Stillabower Michael E. , Gale Nancy , Goldenberg Edward M. 
Published: July 2009

AbstractTwo cases of catastrophic thrombus formation during coronary angioplasty occurred shortly after the operators began using nonionic contrast. This occurred despite systemic heparinization, the adequacy of which was documented by activated clotting times (ACT). Both cases were resistant to balloon inflation and one was refractory to intracoronary thrombolysis. There is a considerable body of evidence documenting that low‐osmolality contrast media, especially those that are nonionic, have less anticoagulant effect than standard contrast media. Several reports have also been published suggesting possible relationships between nonionic contrast and intravascular thrombus formation during coronary angiography and angioplasty. These data are reviewed and recommendations made for utilization of these contrast media.
Prognostic Value of C‐Reactive Protein, Fibrinogen, Interleukin‐6, and Macrophage Colony Stimulating Factor in Severe Unstable Angina
Authors: Rallidis Loukianos S. , Zolindaki Maria G. , Manioudaki Helen S. , Papasteriadis Evangelos G. , Laoutaris Nikolaos P. , Velissaridou Aggeliki H. 
Published: July 2009

AbstractBackground: Inflammatory process plays an important role in the pathogenesis of acute coronary syndromes.Hypothesis: The study was undertaken to evaluate whether admission levels of C‐reactive protein (CRP), fibrinogen, interleukin‐6 (IL‐6), and macrophage colony stimulating factor (MCSF) can predict short‐term prognosis in patients with unstable angina.Methods: C‐reactive protein, fibrinogen, IL‐6, and MCSF were measured on admission in 141 consecutive patients, aged 59 ± 10 years, with unstable angina (Braunwald class IIIb). Patients were divided into two groups according to their in‐hospital outcome: Group 1 comprised 77 patients with a complicated course (2 died, 15 developed nonfatal myocardial infarction, and 60 had recurrence of angina), and Group 2 comprised 64 patients with an uneventful course.Results: Admission median levels of CRP (8.8 vs. 3.1 mg/l, p = 0.0002), fibrinogen (392 vs. 340 mg/dl, p = 0.008), IL‐6 (8.8 vs. 4.5 pg/ml, p = 0.03), and MCSF (434 vs. 307 pg/ml, p = 0.0001) were higher in Group 1 than in Group 2. The MCSF levels were an independent risk factor for in‐hospital events, with an adjusted odds ratio for eventful in‐hospital outcome of 3.3 (95% confidence interval 1‐‐10.9, p = 0.04), and correlated with levels of IL‐6 (rs = 0.52, p = 0.0001), CRP (rs = 0.43, p = 0.0001), and fibrinogen (rs = 0.25, p = 0.004).Conclusions: These findings suggest that among the studied inflammatory indices only increased admission levels of MCSF are strongly and independently related with adverse short‐term prognosis in patients with severe unstable angina.
Tribological properties of WSe2 nanorods as additives
Authors: Yang J. H. , Yao H. X. , Liu Y. Q. , Wei M. B. , Liu Y. , Zhang Y. J. , Wang Y. X. 
Published: July 2009

AbstractThis work demonstrats a convenient and effective approach to synthesize WSe2 nanorods at only 600 °C in argon atmosphere after ball milling. The friction and wear properties of WSe2 nanorods as additives in two kinds of base oil, GyT130 oil and 60N oil were systematically investigated. Compared to base oil, the friction coefficient of the base oil containing WSe2 nanorods was obviously reduced and the wear behaviour was improved. The nanorods in the 60N base oil showed better tribological properties than that in the GYT130 oil. The friction‐and‐wear mechanism of the WSe2 nanorods as lubrication additive was discussed. (© 2009 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Signaling “cross‐talk” is integrated by transcription factors in the development of the anterior segment in the eye
Authors: Gage Philip J. , Zacharias Amanda L. 
Published: July 2009

AbstractExtracellular signaling “cross‐talk” between tissues is an important requirement for development of many organs yet the underlying mechanisms generally remain poorly understood. The anterior segment of the eye, which is constructed from four embryonic lineages, provides a unique opportunity to genetically dissect developmental processes such as signaling “cross‐talk” without fear of inducing lethality. In the current review, we summarize recent data showing that PITX2, a homeodomain transcription factor, integrates retinoic acid and canonical Wnt/β‐catenin signaling during anterior segment development. Because the requirements for retinoic acid signaling, canonical Wnt/β‐catenin signaling, and PITX2 are not unique to the eye, this newly identified pathway may have relevance elsewhere during development and in tissue homeostasis. Developmental Dynamics 238:2149–2162, 2009. © 2009 Wiley‐Liss, Inc.
Cell‐autonomous requirements for Dlg‐1 for lens epithelial cell structure and fiber cell morphogenesis
Authors: Rivera Charlene , Yamben Idella F. , Shatadal Shalini , Waldof Malinda , Robinson Michael L. , Griep Anne E. 
Published: July 2009

AbstractCell polarity and adhesion are thought to be key determinants in organismal development. In Drosophila, discs large (dlg) has emerged as an important regulator of epithelial cell proliferation, adhesion, and polarity. Herein, we investigated the role of the mouse homolog of dlg (Dlg‐1) in the development of the mouse ocular lens. Tissue‐specific ablation of Dlg‐1 throughout the lens early in lens development led to an expansion and disorganization of the epithelium that correlated with changes in the distribution of adhesion and polarity factors. In the fiber cells, differentiation defects were observed. These included alterations in cell structure and the disposition of cell adhesion/cytoskeletal factors, delay in denucleation, and reduced levels of α‐catenin, pERK1/2, and MIP26. These fiber cell defects were recapitulated when Dlg‐1 was disrupted only in fiber cells. These results suggest that Dlg‐1 acts in a cell autonomous manner to regulate epithelial cell structure and fiber cell differentiation. Developmental Dynamics 238:2292–2308, 2009. © 2009 Wiley‐Liss, Inc.
The validity and utility of subtyping bulimia nervosa
Authors: van Hoeken Daphne , Veling Wim , Sinke Sjoukje , Mitchell James E. , Hoek Hans W. 
Published: July 2009

AbstractObjective:To review the evidence for the validity and utility of subtyping bulimia nervosa (BN) into a purging (BN‐P) and a nonpurging subtype (BN‐NP), and of distinguishing BN‐NP from binge eating disorder (BED), by comparing course, complications, and treatment.Method:A literature search of psychiatry databases for studies published in peer‐reviewed journals that used the DSM‐definitions of BN and BED, and included both individuals with BN‐NP and individuals with BN‐P and/or BED.Results:Twenty‐three studies compared individuals with BN‐NP (N = 671) to individuals with BN‐P (N = 1795) and/or individuals with BED (N = 1921), two of which reported on course, 12 on comorbidity and none on treatment response—the indicators for validity and clinical utility. The differences found were mainly quantitative rather than qualitative, suggesting a gradual difference in severity from BN‐P (most severe) through BN‐NP to BED (least severe).Discussion:None of the comparisons provided convincing evidence for the validity or utility of the BN‐NP diagnosis. Three options for the position of BN‐NP in DSM‐V were suggested: (1) maintaining the BN‐NP subtype, (2) dropping nonpurging compensatory behavior as a criterion for BN, so that individuals currently designated as having BN‐NP would be designated as having BED, and (3) including BN‐NP in a broad BN category. © 2009 American Psychiatric Association. Int J Eat Disord 2009
Erythropoiesis: Model systems, molecular regulators, and developmental programs
Authors: Tsiftsoglou Asterios S. , Vizirianakis Ioannis S. , Strouboulis John 
Published: July 2009

AbstractHuman erythropoiesis is a complex multistep developmental process that begins at the level of pluripotent hematopoietic stem cells (HSCs) at bone marrow microenvironment (HSCs niche) and terminates with the production of erythrocytes (RBCs). This review covers the basic and contemporary aspects of erythropoiesis. These include the: (a) cell‐lineage restricted pathways of differentiation originated from HSCs and going downward toward the blood cell development; (b) model systems employed to study erythropoiesis in culture (erythroleukemia cell lines and embryonic stem cells) and in vivo (knockout animals: avian, mice, zebrafish, and xenopus); (c) key regulators of erythropoiesis (iron, hypoxia, stress, and growth factors); (d) signaling pathways operating at hematopoietic stem cell niche for homeostatic regulation of self renewal (SCF/c‐kit receptor, Wnt, Notch, and Hox) and for erythroid differentiation (HIF and EpoR). Furthermore, this review presents the mechanisms through which transcriptional factors (GATA‐1, FOG‐1, TAL‐1/SCL/MO2/Ldb1/E2A, EKLF, Gfi‐1b, and BCL11A) and miRNAs regulate gene pattern expression during erythroid differentiation. New insights regarding the transcriptional regulation of α‐ and β‐globin gene clusters were also presented. Emphasis was also given on (i) the developmental program of erythropoiesis, which consists of commitment to terminal erythroid maturation and hemoglobin production, (two closely coordinated events of erythropoieis) and (ii) the capacity of human embryonic and umbilical cord blood (UCB) stem cells to differentiate and produce RBCs in culture with highly selective media. These most recent developments will eventually permit customized red blood cell production needed for transfusion. © 2009 IUBMB IUBMB Life 61(8): 800–830, 2009
Cholinergic modulation of angiogenesis: Role of the 7 nicotinic acetylcholine receptor
Authors: Wu Jenny C.F. , Chruscinski Andrzej , De Jesus Perez Vinicio A. , Singh Harvir , Pitsiouni Maria , Rabinovitch Marlene , Utz Paul J. , Cooke John P. 
Published: July 2009

AbstractPathological angiogenesis contributes to tobacco‐related diseases such as malignancy, atherosclerosis and age‐related macular degeneration. Nicotine acts on endothelial nicotinic acetylcholine receptors (nAChRs) to activate endothelial cells and to augment pathological angiogenesis. In the current study, we studied nAChR subunits involved in these actions. We detected mRNA for all mammalian nAChR subunits except α2, α4, γ, and δ in four different types of ECs. Using siRNA methodology, we found that the α7 nAChR plays a dominant role in nicotine‐induced cell signaling (assessed by intracellular calcium and NO imaging, and studies of protein expression and phosphorylation), as well as nicotine‐activated EC functions (proliferation, survival, migration, and tube formation). The α9 and α7 nAChRs have opposing effects on nicotine‐induced cell proliferation and survival. Our studies reveal a critical role for the α7 nAChR in mediating the effects of nicotine on the endothelium. Other subunits play a modulatory role. These findings may have therapeutic implications for diseases characterized by pathological angiogenesis. J. Cell. Biochem. 108: 433–446, 2009. © 2009 Wiley‐Liss, Inc.
In vitro labeling of human umbilical cord mesenchymal stem cells with superparamagnetic iron oxide nanoparticles
Authors: Hu Sheng‐Li , Zhang Jiu‐Quan , Hu Xiang , Hu Rong , Luo Hai‐Shui , Li Fei , Xia Yong‐Zhi , Li Jiang‐Tao , Lin Jiang‐Kai , Zhu Gang , Feng Hua 
Published: July 2009

AbstractHuman umbilical cord mesenchymal stem cells (hUC‐MSCs) transplantation has been shown to promote regeneration and neuroprotection in central nervous system (CNS) injuries and neurodegenerative diseases. To develop this approach into a clinical setting it is important to be able to follow the fates of transplanted cells by noninvasive imaging. Neural precursor cells and hematopoietic stem cells can be efficiently labeled by superparamagnetic iron oxide (SPIO) nanoparticle. The purpose of our study was to prospectively evaluate the influence of SPIO on hUC‐MSCs and the feasibility of tracking for hUC‐MSCs by noninvasive imaging. In vitro studies demonstrated that magnetic resonance imaging (MRI) can efficiently detect low numbers of SPIO‐labeled hUC‐MSCs and that the intensity of the signal was proportional to the number of labeled cells. After transplantation into focal areas in adult rat spinal cord transplanted SPIO‐labeled hUC‐MSCs produced a hypointense signal using T2‐weighted MRI in rats that persisted for up to 2 weeks. This study demonstrated the feasibility of noninvasive imaging of transplanted hUC‐MSCs. J. Cell. Biochem. 108: 529–535, 2009. © 2009 Wiley‐Liss, Inc.
Protective effect of atorvastatin in cultured osteoarthritic chondrocytes
Authors: Simopoulou Theodora , Malizos Konstantinos N. , Poultsides Lazaros , Tsezou Aspasia 
Published: July 2009

AbstractThe aim of our study was to evaluate the in vitro effect of an HMG‐CoA reductase inhibitor, atorvastatin, on the expression of significant anabolic and catabolic genes in human osteoarthritic chondrocytes and to explore the metabolic pathways involved in this process. Human articular osteoarthritic chondrocytes were cultured in the presence and absence of atorvastatin (10 and 50 µmol/L) for 24 h. Metalloproteinase 13 (MMP‐13), collagen type II (COL2A1), and aggrecan (AGC) mRNA expression levels were evaluated by real‐time PCR, and protein expression levels by Western blot analysis. IL‐1β levels in culture medium was analyzed with ELISA. The effect of the treatment with the mevalonate isoprenoid derivatives farnesol and geranylgeraniol, or the cholesterol precursor squalene, was evaluated in the atorvastatin osteoarthritic chondrocyte cultures. Incubation of osteoarthritic chondrocyte cultures with atorvastatin produced a significant dose‐dependent reduction in IL‐1β production. Atorvastatin supplementation in cultures produced a decrease in MMP‐13 mRNA and protein expression levels, which was reversed by the addition of farnesol. Regarding AGC and COL2A1 mRNA expression, a significant increase was observed only in chondrocytes cultures treated with 50 µmol/L atorvastatin. Our findings suggest that atorvastatin may have potential chondroprotective effects mostly by reducing cartilage degradation. © 2009 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 28:110–115, 2010
Enhancement of freezing stability in mashed potatoes by the incorporation of kappa‐carrageenan and xanthan gum blends
Authors: Alvarez María Dolores , Fernández Cristina , Canet Wenceslao 
Published: July 2009

AbstractBACKGROUND: To ameliorate the detrimental effects of freezing and thawing, blends of κ‐carrageenan (κ‐C) and xanthan gum (XG) were added to frozen/thawed mashed potatoes (F/TM potatoes). Product was tested by textural and rheological measurements, other quality parameters and sensory analyses. The effects of variation in levels of κ‐C (1.5–4.5 g kg−1) and XG (0.5–2.5 g kg−1) concentrations were studied.RESULTS: Instrumental measurements and sensory analyses indicated that 4.5 g kg−1κ‐C and 2.5 g kg−1 XG provided better thickening. κ‐C provided the appropriate texture, while XG imparted creaminess to the product, which could be associated with an increase in the amount of XG–water interactions. Addition of κ‐C had a major impact on textural properties, gel strength and viscoelastic behaviour, whereas XG influenced steady properties, colour, water‐holding capacity (WHC) and overall acceptability (OA).CONCLUSION: The OA of F/TM potatoes was mostly improved by addition of cryoprotectant blends, which is ascribed to improvement of F/TM potatoes texture by retarding starch retrogradation, increasing WHC, and enhancing the principal characteristics determining consumer acceptance. Creaminess was the most crucial factor for OA of the products. Addition of both polysaccharides at a low concentration (each cryoprotectant at 1.5 g kg−1) is recommended. Copyright © 2009 Society of Chemical Industry
96‐Channel receive‐only head coil for 3 Tesla: Design optimization and evaluation
Authors: Wiggins Graham C. , Polimeni Jonathan R. , Potthast Andreas , Schmitt Melanie , Alagappan Vijay , Wald Lawrence L. 
Published: July 2009

AbstractThe benefits and challenges of highly parallel array coils for head imaging were investigated through the development of a 3T receive‐only phased‐array head coil with 96 receive elements constructed on a close‐fitting helmet‐shaped former. We evaluated several designs for the coil elements and matching circuitry, with particular attention to sources of signal‐to‐noise ratio (SNR) loss, including various sources of coil loading and coupling between the array elements. The SNR and noise amplification (g‐factor) in accelerated imaging were quantitatively evaluated in phantom and human imaging and compared to a 32‐channel array built on an identical helmet‐shaped former and to a larger commercial 12‐channel head coil. The 96‐channel coil provided substantial SNR gains in the distal cortex compared to the 12‐ and 32‐channel coils. The central SNR for the 96‐channel coil was similar to the 32‐channel coil for optimum SNR combination and 20% lower for root‐sum‐of‐squares combination. There was a significant reduction in the maximum g‐factor for 96 channels compared to 32; for example, the 96‐channel maximum g‐factor was 65% of the 32‐channel value for acceleration rate 4. The performance of the array is demonstrated in highly accelerated brain images. Magn Reson Med, 2009. © 2009 Wiley‐Liss, Inc.
Reliability of pharmacokinetic parameters: Small vs. medium‐sized contrast agents
Authors: Jaspers Karolien , Aerts Hugo J.W.L. , Leiner Tim , Oostendorp Marlies , van Riel Natal A.W. , Post Mark J. , Backes Walter H. 
Published: July 2009

AbstractCurrent clinical applications of dynamic contrast‐enhanced MRI (DCE‐MRI) are based on the extravasation of relatively small contrast agents (SCAs). SCAs are considered disadvantageous, as they require high image sampling rates. Medium‐sized contrast agents (MCAs) leak more slowly into tissue and allow longer dynamic acquisition times, enabling improved image quality. The influence of molecular size on the reliability of pharmacokinetic parameters, including the transfer constant Ktrans, was investigated. Computer simulations were performed, with in vivo measured arterial input functions (AIFs), to determine the bias and variance of pharmacokinetic parameters as a function of contrast agent size, sampling frequency, noise level, and acquisition time. Better reliability of all parameters was obtained for the MCA compared to the SCA. To obtain similar variance (10%) in Ktrans, the sampling frequency for the SCA (28 min−1) had to be 20 times faster than for the MCA (1.3 min−1). Optimal reliability in parameter estimation required longer acquisition times for MCAs (13 min for the fraction of the extravascular extracellular space into which the contrast agent distributes (ve) and 5 min for Ktrans) than for SCAs (1.7 min for Ktrans and ve). Reliable estimation of the fractional blood plasma volume (vp) was only achieved with MCAs. In conclusion, MCAs provided superior reliability for pharmacokinetic parameter estimation compared to SCAs. Magn Reson Med, 2009. © 2009 Wiley‐Liss, Inc.
Exact solutions for nonlinear partial differential equations via Exp‐function method
Authors: Aminikhah Hossein , Moosaei Hossein , Hajipour Mojtaba 
Published: July 2009

AbstractIn this article, the Exp‐function method is applied to nonlinear Burgers equation and special fifth‐order partial differential equation. Using this method, we obtain exact solutions for these equations. The method is straightforward and concise, and its applications are promising. This method can be used as an alternative to obtain analytical and approximate solutions of different types of nonlinear differential equations. © 2009 Wiley Periodicals, Inc. Numer Methods Partial Differential Eq 2010