bluuebunny/crossref_metadata_2025_split huggingface dataset:
Procedure Volume and Outcomes With WATCHMAN Left Atrial Appendage Occlusion
Authors: Friedman Daniel J. , Du Chengan , Zimmerman Sarah , Tan Zhen , Lin Zhenqiu , Vemulapalli Sreekanth , Kosinski Andrzej S. , Piccini Jonathan P. , Pereira Lucy , Minges Karl E. , Faridi Kamil F. , Masoudi Frederick A. , Curtis Jeptha P. , Freeman James V. 
Published: June 2024

BACKGROUND:
Procedure volumes are associated with outcomes for many cardiovascular procedures, leading to guidelines on minimum volume thresholds for certain procedures; however, the volume-outcome relationship with left atrial appendage occlusion is poorly understood. As such, we sought to determine the relationship between hospital and physician volume and WATCHMAN left atrial appendage occlusion procedural success overall and with the new generation WATCHMAN FLX device.

METHODS:
We performed an analysis of WATCHMAN procedures (January 2019 to October 2021) from the National Cardiovascular Data Registry LAAO Registry. Three-level hierarchical generalized linear models were used to assess the adjusted relationship between procedure volume and procedural success (device released with peridevice leak <5 mm, no in-hospital major adverse events).

RESULTS:

Among 87 480 patients (76.2±8.0 years; 58.8% men; mean CHA
2
DS
2
-VASc score, 4.8±1.5) from 693 hospitals, the procedural success rate was 94.2%. With hospital volume Q4 (greatest volume) as the reference, the likelihood of procedural success was significantly less among Q1 (odds ratio [OR], 0.66 [CI, 0.57–0.77]) and Q2 (OR, 0.78 [CI, 0.69–0.90]) but not Q3 (OR, 0.95 [CI, 0.84–1.07]). With physician volume Q4 (greatest volume) as the reference, the likelihood of procedural success was significantly less among Q1 (OR, 0.72 [CI, 0.63–0.82]), Q2 (OR, 0.79 [CI, 0.71–0.89]), and Q3 (OR, 0.88 [CI, 0.79–0.97]). Among WATCHMAN FLX procedures, there was attenuation of the volume-outcome relationships, with statistically significant but modest absolute differences of only ≈1% across volume quartiles.

CONCLUSIONS:
In this contemporary national analysis, greater hospital and physician WATCHMAN volumes were associated with increased procedure success. The WATCHMAN FLX transition was associated with increased procedural success and less heterogeneity in outcomes across volume quartiles. These findings indicate the importance of understanding the volume-outcome relationship for individual left atrial appendage occlusion devices.
Natural History of Coronary Atherosclerosis in Patients With Aortic Stenosis Undergoing Transcatheter Aortic Valve Replacement: The Role of Quantitative Flow Ratio
Authors: Colaiori Iginio , Paolucci Luca , Mangiacapra Fabio , Barbato Emanuele , Ussia Gian Paolo , Grigioni Francesco , Demola Pierluigi , Vitolo Marco , Benatti Giorgio , Vignali Luigi , Gabbieri Davide , Magnavacchi Paolo , Sgura Fabio Alfredo , Boriani Giuseppe , Guiducci Vincenzo 
Published: June 2024

BACKGROUND:
The prognostic impact of functionally significant coronary artery disease, as assessed with quantitative flow ratio (QFR), in patients with severe aortic stenosis treated with transcatheter aortic valve replacement is unknown.

METHODS:
This is a retrospective study with blind analysis of angiographic data, enrolling consecutive patients with severe aortic stenosis treated with transcatheter aortic valve replacement at 4 Italian centers. None of the patients enrolled received pre-transcatheter aortic valve replacement or concomitant coronary revascularization, either for the absence of significant coronary stenoses or by clinical decision. Visual estimation of diameter stenosis and QFR analysis were performed in all coronary arteries. The end point was all-cause mortality at a 3-year follow-up.

RESULTS:

A total of 318 patients were enrolled. At visual estimation, 140 patients (44%) presented a diameter stenosis ≥50% in at least 1 coronary artery, whereas 78 patients (24.5%) had at least 1 vessel with QFR <0.80 and, therefore, included in the positive QFR group. Overall, 69 (21.7%) patients died during the follow-up. In the Kaplan-Meier analysis, patients with positive QFR experienced significantly higher rates of death during follow-up compared with those without (51.1% versus 12.1%;
P
<0.001), whereas no significant difference was evident in terms of death between patients with or without significant coronary artery disease according to angiographic evaluation (24.3% versus 19.7%;
P
=0.244). In a multivariate regression model, positive QFR was an independent predictor of all-cause death during follow-up (hazard ratio, 5.31 [95% CI, 3.21–8.76]).

CONCLUSIONS:
Coronary QFR can predict mortality in patients with severe aortic stenosis treated with transcatheter aortic valve replacement without revascularization.
Health-Status Outcomes in Older Patients With Myocardial Infarction: Physiology-Guided Complete Revascularization Versus Culprit-Only Strategy
Authors: Campo Gianluca , Guiducci Vincenzo , Escaned Javier , Moreno Raul , Casella Gianni , Cavazza Caterina , Cerrato Enrico , Contarini Marco , Arena Marco , Iniguez Romo Andres , Gutiérrez Ibañes Enrique , Scarsini Roberto , Vadalà Giuseppe , Andò Giuseppe , Pilato Gerlando , Musto d’Amore Sergio , Capecchi Alessandro , Trillo Nouche Ramiro , Moscarella Elisabetta , Gambino Alfonso , Pavani Marco , Zanetti Anna , Pesenti Nicola , Dudek Dariusz , Barbato Emanuele , Tebaldi Matteo , Biscaglia Simone 
Published: June 2024

BACKGROUND:
The FIRE trial (Functional Assessment in Elderly Myocardial Infarction Patients With Multivessel Disease) enrolled 1445 older (aged ≥75 years) patients with myocardial infarction and multivessel disease in Italy, Spain, and Poland. Patients were randomized to physiology-guided complete revascularization or treatment of the only culprit lesion. Physiology-guided complete revascularization significantly reduced ischemic adverse events at 1 year. This prespecified analysis investigated the changes between the 2 study groups in angina status, quality of life, physical performance, and frailty.

METHODS:
Patients underwent validated scales at hospital discharge (baseline) and 1 year later. Angina status was evaluated using the Seattle Angina Questionnaire, health-related quality of life by EQ visual analog scale, physical performance by short physical performance battery, and frailty by the clinical frailty scale. Mixed models for repeated measures analysis were used to study the association between the treatment arms, time, and scales.

RESULTS:
Baseline and 1-year Seattle Angina Questionnaire, EQ visual analog scale, short physical performance battery, and clinical frailty scale were collected in around two-thirds of the entire FIRE study population. The mean age was 80.9±4.6 years (female sex, 35.9%). Overall, 35.3% were admitted for ST-segment–elevation myocardial infarction, whereas the others were admitted for non–ST-segment–elevation myocardial infarction. Physiology-guided complete revascularization, compared with culprit-only revascularization, was associated with greater improvement in terms of angina status (Seattle Angina Questionnaire summary score, 7.3 [95% CI, 6.1–8.6] points), health-related quality of life (EQ visual analog scale, 6.2 [95% CI, 4.4–8.1] points), and physical performance (short physical performance battery, 1.1 [95% CI, 0.9–1.3] points). After 1 year, patients randomized to culprit-only revascularization experienced a deterioration in frailty status (clinical frailty scale, 0.2 [95% CI, 0.1–0.3] points), which was not observed in patients randomized to physiology-guided complete revascularization.

CONCLUSIONS:
The present analysis suggested that a physiology-guided complete revascularization is associated with consistent benefits in terms of angina status, quality of life, physical performance, and the absence of further deterioration of the frailty status.

REGISTRATION:

URL:
https://www.clinicaltrials.gov
; Unique identifier: NCT03772743.
Creating diverse and inclusive scientific practices for research datasets and dissemination
Authors: Kam Julia W.Y. , Badhwar AmanPreet , Borghesani Valentina , Lee Kangjoo , Noble Stephanie , Raamana Pradeep Reddy , Ratnanather J. Tilak , Tan Davynn G.H. , Oestreich Lena K.L. , Lee Hyang Woon , Marzetti Laura , Nakua Hajer , Rippon Gina , Olsen Rosanna , Pozzobon Alyssa , Uddin Lucina Q. , Yanes Julio Alejandro , Tzovara Athina 
Published: June 2024

Abstract
Diversity, equity, and inclusivity (DEI) are important for scientific innovation and progress. This widespread recognition has resulted in numerous initiatives for enhancing DEI in recent years. Although progress has been made to address gender and racial disparities, there remain biases that limit the opportunities for historically under-represented researchers to succeed in academia. As members of the Organization for Human Brain Mapping (OHBM) Diversity and Inclusivity Committee (DIC), we identified the most challenging and imminent obstacles toward improving DEI practices in the broader neuroimaging field. These obstacles include the lack of diversity in and accessibility to publicly available datasets, barriers in research dissemination, and/or barriers related to equitable career advancements. In order to increase diversity and promote equity and inclusivity in our scientific endeavors, we suggest potential solutions that are practical and actionable to overcome these barriers. We emphasize the importance of the enduring and unwavering commitment required to advance DEI initiatives consistently. By doing so, the OHBM and perhaps other neuroscience communities will strive toward a future that is not only marked by scientific excellence but also characterized by diverse, inclusive, and equitable opportunities for all, including historically under-represented individuals around the world.
Misperceived Social Norms and Willingness to Act Against Climate Change
Authors: Andre Peter , Boneva Teodora , Chopra Felix , Falk Armin 
Published: June 2024

Abstract
We document the individual willingness to act against climate change and study the role of social norms in a large sample of US adults. Individual beliefs about social norms positively predict pro-climate donations, comparable in strength to universal moral values and economic preferences. However, we document systematic misperceptions of social norms. Respondents vastly underestimate the prevalence of climate-friendly behaviors and norms. Correcting these misperceptions in an experiment causally raises individual willingness to act against climate change and individual support for climate policies. The effects are strongest for individuals who are skeptical about the existence and threat of global warming.
The relevance of Evolutionary Significant Units for the conservation of island-restricted reptiles: Tarentola boettgeri bischoffi as a case study
Authors: Rato Catarina , Oliveira Paulo , Menezes Dília , Funk Stephan M. , Rebelo Rui , Nogales Manuel , Rocha Ricardo 
Published: June 2024

Abstract
Within vertebrates, reptiles are good island colonisers, often leading to considerable levels of intraspecific diversity among populations inhabiting different islands/archipelagos. This study explores the mitochondrial phylogeographic structure of Tarentola boettgeri, a gecko species endemic to the Macaronesian archipelagos of Selvagens and the Canary Islands. Our research introduces a novel monophyletic group, comprising the populations from the islands of Selvagem Pequena and Ilhéu de Fora. Furthermore, we confirm the previously identified genetic clusters associated with Selvagem Grande, Gran Canaria and El Hierro. We estimate that the origin of T. boettgeri dates to the upper Miocene (ca. 6.4 Mya), and that the separation of T. boettgeri bischoffi on Selvagem Grande, Selvagem Pequena, and Ilhéu de Fora, occurred ca. 0.5 Mya. The absence of genetic differences between Selvagem Pequena and Ilhéu de Fora suggests recent gene flow or founder events, possibly facilitated by land connections during major glaciations. Conversely, the geographic barriers between Selvagem Grande and Selvagem Pequena likely persisted, preventing genetic admixing. The significant genetic distances observed among all populations underscore the necessity of an integrative taxonomic revision for T. boettgeri. In light of our findings, and with particular consideration of the small population sizes of T. boettgeri bischoffi on Selvagem Pequena and Ilhéu de Fora, we propose that the identified monophyletic groups should be managed as Evolutionarily Significant Units (ESUs). Accordingly, our study highlights the importance of recognizing ESUs in island-restricted reptile populations for targeted conservation efforts, especially given their unique intraspecific diversity and the vulnerability of their habitats.
Glassware Influences the Perception of Orange Juice in Simulated Naturalistic versus Urban Conditions
Authors: Wu Chunmao , Li Pei , Spence Charles 
Published: June 2024

Abstract
The latest research demonstrates that people’s perception of orange juice can be influenced by the shape/type of receptacle in which it happens to be served. Two studies are reported that were designed to investigate the impact, if any, that the shape/type of glass might exert over the perception of the contents, the emotions induced on tasting the juice and the consumer’s intention to purchase orange juice. The same quantity of orange juice (100 ml) was presented and evaluated in three different glasses: a straight-sided, a curved and a tapered glass. Questionnaires were used to assess taste (aroma, flavour intensity, sweetness, freshness and fruitiness), pleasantness and intention to buy orange juice. Study 2 assessed the impact of the same three glasses in two digitally rendered atmospheric conditions (nature vs urban). In Study 1, the perceived sweetness and pleasantness of the orange juice was significantly influenced by the shape/type of the glass in which it was presented. Study 2 reported significant interactions between condition (nature vs urban) and glass shape (tapered, straight-sided and curved). Perceived aroma, flavour intensity and pleasantness were all significantly affected by the simulated audiovisual context or atmosphere. Compared to the urban condition, perceived aroma, freshness, fruitiness and pleasantness were rated significantly higher in the nature condition. On the other hand, flavour intensity and sweetness were rated significantly higher in the urban condition than in the natural condition. These results are likely to be relevant for those interested in providing food services, or company managers offering beverages to their customers.
The Nursing Crisis of the 1960s: Origins and Municipal Crisis Management
Authors: Pfütsch Pierre , Kreutzer Susanne 
Published: June 2024

Abstract
The nursing crisis that developed in West Germany in the 1960s was considered a major social challenge. The causes were complex and lay primarily in the denominational motherhouse system, which gradually began to erode around this time. The problem of a shortage of young staff went in tandem with the dissolution of the old structures and was exacerbated by an expansion of the hospitals, which required more and more personnel. The responses varied greatly from region to region. The example of the city of Stuttgart serves an in-depth examination both of federal policy strategies for solving the problem and of the specific implementation of these strategies within local communities. Measures included advertising for new staff, diversifying training, recruiting foreign nursing staff, and improving working conditions.
When Infant Mortality Was Born: Dutch Preventive Child Health Care without the State, 1890–1930
Authors: van der Meer Martijn , Jacobs Noortje 
Published: June 2024

Abstract
This article investigates the emergence of Dutch preventive child health care in the first decades of the twentieth century. It shows that the rise of collective action on this terrain followed from the recognition of “infant mortality” as a public problem – a late–nineteenth century configuration that went hand in hand with the professionalisation of paediatrics. It also shows that the organisational forms that this collective action took depended on whose health was perceived to be at stake in specific articulations of the public problem of infant mortality. Finally, this article explores the motives of the Dutch state in the organisation of public health in the interbellum and queries the relationship between the state and public health more broadly. Drawing on pragmatist philosophy, we argue that states are best understood as the result of historically contingent processes that take on different forms in different times and places. Such histories enable a better view of the elements at play in the organisation of collective action and of the pivotal role played therein by the perception of public problems.
Surface Currents and Relative-Wind Stress in Coupled Ocean–Atmosphere Simulations of the Northern California Current System
Authors: Samelson R. M. , Durski S. M. , Chelton D. B. , Skyllingstad E. D. , Barbour P. L. 
Published: June 2024

Abstract
The dependence of surface-current damping on the definition of surface current for the relative wind is examined in coupled ocean–atmosphere numerical simulations of the northern California Current System (nCCS) during March–October 2009. The model response is analyzed for wind stress computed from relative wind for six different choices of effective model surface velocity. Simulations without surface-current coupling are also considered. As a function of the geographically varying uppermost grid-level depth, the model uppermost grid-level velocity is found to have a wind-drift component with a log-layer structure. Mean geostrophic wind work is concentrated in the shelf and slope regions during March–May (MAM) and in the deep offshore region in June–September (JJAS). The surface-current damping effect on ocean kinetic energy depends more strongly on the parameterization of atmospheric planetary boundary layer (PBL) turbulence than on the surface-current coupling formulation: weaker PBL mixing gives stronger surface-current damping. The damping effect is stronger in the less energetic offshore region than in the more energetic region closer to the coast. During MAM, the changes in kinetic energy and geostrophic wind work in the shelf and slope regions are spatially correlated, while during JJAS, the changes in geostrophic wind work are strongly modulated by SST–stress coupling. The wind-drift-corrected surface-current formulations result in large changes in the effective wind work based on the product of stress and relative-wind surface current but result in only small changes in the kinetic energy of the circulation.

Significance Statement
Ocean currents and atmospheric winds are coupled by the exchange of momentum across the air–sea interface, the strength of which depends on the relative wind, the difference between the surface wind and surface current. The purpose of this work was to examine the dependence of a coupled ocean–atmosphere model of the northern California Current System (nCCS) on the representations of the relative-wind surface current and turbulent mixing in the lower atmosphere. The model surface current was found to have a shallow wind-drift response. The model ocean circulation was driven primarily by near-coast winds during the spring and by offshore winds during the summer. The ocean response depended more strongly on the atmospheric turbulent mixing than on the surface current representation.
Association of Medical School Gap Year Research and Degree Programs With Otolaryngology Interview and Match Outcomes
Authors: Boyi Trinithas , Benjamin William J. , Lenze Nicholas R. , Brenner Michael J. , Mihalic Angela P. , Kupfer Robbi A. , Judson Benjamin L. , Lee Yan H. 
Published: June 2024

Objective: To investigate whether a gap year for either research or a master’s degree is associated with interview offers or match outcomes among otolaryngology applicants. Methods: Using the Texas Seeking Transparency in Application to Residency (Texas STAR) database, we conducted a cross-sectional analysis of otolaryngology applicants from 2018 to 2022. Applicants were stratified based on the presence and type of gap year during medical school. Applicant characteristics, signaling, research productivity, and application costs were analyzed, with primary outcomes including number of interview offers and match status. Results: Among 564 otolaryngology applicant respondents to the Texas STAR survey, 160 (28%) reported a gap year, including 64 (40%) applicants participating in a research year, 65 (41%) completing a Master of Public Health or Science (MPH and MSc), and 31 (19%) completing a Master of Business Administration, Education, or other degree (MBA and MEd). Gap-year applicants who completed a research year or MPH/MSc degree received more interview offers ( P < .01) than MBA, MEd applicants, or those without a gap year. Applicants with a research year had the most publications, oral presentations, abstracts, posters, and research experiences (all P < .01). When controlling for USMLE scores, clerkship honors, and applications submitted, applicants completing a research year or an MPH/MSc-degree received increased interview offers ( P < .01). No significant differences were seen in expenditures or match rates. Conclusions: Research and MPH/MSc gap years were associated with increased residency interview offers but not increased match success. Further longitudinal studies are needed to assess how yearlong experiences affect long-term career outcomes.
D-dimer levels predict the treatment efficacy and prognosis of esophageal squamous cell carcinoma treated with PD-1/PD-L1 inhibitors
Authors: Wu Yuchen , Liu Xin , Li Huihui , Wang Wenjing , Ye Lisha , Zhou Yun , Chen Da 
Published: June 2024

Objectives This study aimed to explore the value of D-dimer levels in predicting the treatment efficacy and prognosis of advanced esophageal squamous cell carcinoma (ESCC) treated with programmed cell death protein-1/programmed death-ligand 1 (PD-1/PD-L1) inhibitors. Methods The study retrospectively analyzed 233 ESCC patients who received PD-1/PD-L1 inhibitors. The optimal cut-off values for platelets, fibrinogen, and D-dimer were calculated based on maximally selected rank statistics for patients’ overall survival. Univariate and multivariate analyses of progression-free survival and overall survival were conducted by Cox proportional hazards regression model. Subgroup analyses of D-dimer levels in different fibrinogen levels were performed by log-rank test. Results The multivariate Cox regression analyses demonstrated that ESCC patients with D-dimer levels > 236 ng/mL exhibited both poorer progression-free survival ( P = 0.004) and overall survival ( P < 0.0001) compared to those with low D-dimer levels. The subgroup analyses further indicated that in the group of low fibrinogen levels, the higher D-dimer levels of ESCC patients exhibited significantly shorter progression-free survival ( P = 0.0021) and overall survival ( P < 0.0001). Conclusions The study revealed that the D-dimer levels possess predictive value for the treatment efficacy and prognosis of ESCC patients treated with PD-1/PD-L1 inhibitors.