bluuebunny/crossref_metadata_2025_split huggingface dataset:
Intrauterine administration of peripheral blood mononuclear cells enhances early development of the pre‐implantation bovine embryo
Authors: Ideta Atsushi , Hayama Koh , Nakamura Yuuki , Sakurai Toshihiro , Tsuchiya Kanami , Tanaka Sachi , Yamaguchi Takahiro , Fujiwara Hiroshi , Imakawa Kazuhiko , Aoyagi Yoshito 
Published: November 2010

AbstractIntrauterine administration of peripheral blood mononuclear cells (PBMCs) prior to bovine embryo transfer (ET) was previously shown to improve the pregnancy rate. To better understand how PBMCs improve the pregnancy rate, we examined gene expression in the cells from uterine lumen and evaluated the morphology of bovine pre‐attachment embryos in utero following intrauterine administration of PBMCs. On day 3 of the estrous cycle (day 0 = estrous), bovine PBMCs were isolated and suspended in RPMI 1640, and were incubated for 24 hr. The cultured PBMCs were administered non‐surgically to the uterine horn ipsilateral to the corpus luteum on day 4 of the estrous cycle (PBMC group). On day 9, endometrial–luminal lymphoid cells from uterine lumen ipsilateral to the corpus luteum were collected by uterine flushing. Transcripts for macrophage‐colony stimulating factor in the lymphoid cells were more abundant in the PBMC group than in the control group (P < 0.05). On day 7 (of the separate experiments), five blastocysts were each transferred to the luminal area, to which PBMCs had been administered on day 4. These embryos were allowed to develop in utero until day 15 of gestation, when embryos were non‐surgically retrieved from the uterus. The average length of trophoblasts recovered from the PBMC group was significantly longer than that of the control group (51.6 ± 7.8 vs. 27.4 ± 6.0 mm, P < 0.05). Our results strongly suggest that intrauterine administration of PBMCs improves endometrial environment, which promotes early development of pre‐attachment conceptuses. Mol. Reprod. Dev. 77:954–962, 2010. © 2010 Wiley‐Liss, Inc.
The effects of supplier‐to‐buyer identification on operational performance—An empirical investigation of inter‐organizational identification in automotive relationships
Authors: Corsten Daniel , Gruen Thomas , Peyinghaus Marion 
Published: November 2010

AbstractOver the past decade conceptual and empirical research in operations management has embraced the idea that collaborative supplier–buyer relationships are a source of competitive advantage for manufacturing firms. Anecdotal evidence from the Japanese and U.S. automotive industry and emerging research suggests that inter‐organizational identification of suppliers with their buyers, termed supplier‐to‐buyer identification, is an unexplored factor of relational advantage. This study presents a model and empirical test that supplier‐to‐buyer identification fosters superior operational performance by enhancing trust, supplier relation‐specific investments, and information exchange. Through a survey of 346 automotive supplier–buyer relationships, the findings show that supplier‐to‐buyer identification directly impacts supplier relationship‐specific investments and information exchange, although most of the latter effect is mediated by trust. The findings also indicate that supplier relation‐specific investments and information exchange play different but complementary roles in influencing operational performance. The results suggest new directions for supplier–buyer relationship research in operations management and important managerial implications.
Physical Therapy Workforce in the United States: Forecasting Nationwide Shortages
Authors: Zimbelman Janice L. , Juraschek Stephen P. , Zhang Xiaoming , Lin Vernon W.‐H. 
Published: November 2010

ObjectiveTo examine current and future physical therapy (PT) job surplus/shortage trends across the United States.DesignForecast models and grading methodology previously published for nursing were used to evaluate individual state PT job shortages from 2008 to 2030.SettingNot applicable.ParticipantsNot applicable.MethodsThe forecast model used to project PT job supply and demand accounted for changes in age and population size on the basis of estimates from the U.S. Census Bureau for each of the 50 states. PT shortages were assigned letter grades on the basis of shortage ratios (difference between demand and supply per 10,000 people) to evaluate PT shortages and describe the changing PT workforce in each state.ResultsOn the basis of current trends, demand for PT services will outpace the supply of PTs within the United States. Shortages are expected to increase for all 50 states through 2030. By 2030, the number of states receiving below‐average grades for their PT shortages will increase from 12 to 48. States in the Northeast are projected to have the smallest shortages, whereas states in the south and west are projected to have the largest shortages.ConclusionThese data serve to provide health professionals, policy makers, and stakeholders with a means of assessing current and future PT needs. Discussion of the issues surrounding PT shortages and ongoing assessment of supply and demand must ensue to mitigate projected shortages. Although our model has several limitations and may be oversimplified, it is the first attempt to use available, creditable data to examine both supply and demand for the entire country. Follow‐up studies that use more complex modeling are needed to adequately forecast future trends beyond that accomplished in the current article. Monitoring trends over time is critical to maintain an appropriate balance between PT supply and demand that meets the population needs.
Are Electrodiagnostic Study Findings Related to a Patient's Response to Epidural Steroid Injection?
Authors: Marchetti Jason , Verma‐Kurvari Sunita , Patel Nayan , Ohnmeiss Donna D. 
Published: November 2010

ObjectiveTo determine if improvements in pain after epidural steroid injections (ESIs) were related to electromyographic (EMG) findings in patients with radicular symptoms and clinical findings consistent with radiculopathy.DesignRetrospective chart review.SettingMultisite spine clinic.PatientsData were analyzed from 89 patients who had needle EMG within 6 months of ESI between 2005 and 2008.MethodsClinical and demographic data and results of EMG testing from qualified patients were recorded from patient charts at least 10 days after ESI. Evidence of radiculopathy on EMG reports was classified as positive, normal, or equivocal. In all 3 EMG groups, the percentage of patients who had 50% improvement in leg pain after ESI was noted. As a secondary analysis, improvement in pre‐ESI to post‐ESI leg and back pain scores in the EMG groups were compared.Outcome MeasurementsThe clinical outcome measurements were visual analog scale (VAS) scores assessing leg and back pain. ESI relief was defined as at least 50% improvement in the VAS score assessing leg pain after the injection.ResultsEMG findings were normal in 47.2%, positive in 31.5%, and equivocal in 21.3% of patients. No significant differences were found in the percentages of patients experiencing a positive response to the ESI with respect to EMG findings. Forty‐three percent of patients with normal EMG findings (18/42), 25.0% of patients with positive EMG findings (7/28), and 31.6% patients with equivocal EMG findings (6/19) had relief after ESI. In all 3 EMG groups, a statistically significant improvement in mean VAS scores was found after ESI.ConclusionsMean leg and back pain scores improved significantly after ESI in all 3 EMG groups: those with positive, normal, and equivocal findings. Results of this study do not suggest that ESI is contraindicated in patients with normal EMG findings.
Characteristics and Predictors of Short‐Term Outcomes in Individuals Self‐selecting Yoga or Physical Therapy for Treatment of Chronic Low Back Pain
Authors: Evans Dian Dowling , Carter Michael , Panico Richard , Kimble Laura , Morlock Jennifer T. , Spears Manjula Judith 
Published: November 2010

ObjectiveTo compare clinical and demographic characteristics of individuals self‐selecting yoga or physical therapy (PT) for treatment of chronic low back pain (cLBP) and to examine predictors of short‐term pain and functional outcomes.DesignDescriptive, longitudinal study.SettingsA hospital‐based clinic that offers modified integral yoga classes for cLBP and 2 outpatient PT clinics that offer exercise‐based PT.ParticipantsAdults (n = 53) with cLBP ≥12 weeks: yoga (n = 27), PT (n = 26).MethodsYoga participants attended a 6‐week, once weekly, 2‐hour yoga class. PT participants underwent twice weekly, 1‐hour individualized PT. Data were collected at baseline and at 6 weeks. Groups were compared by using χ2 and independent samples t‐tests. Hierarchical linear regression was used to predict treatment outcomes.Main Outcome MeasuresDisability (Roland Morris Disability Questionnaire), health status (Rand Short Form 36 Health Survey 1.0), pain bothersomeness (numerical rating scale), back pain self‐efficacy (Back Pain Self‐Efficacy Scale), and treatment satisfaction.ResultsAt baseline, yoga participants were significantly less disabled (P = .013), had higher health status (P = .023), greater pain self‐efficacy (P = .012), and less average pain bothersomeness (P = .001) compared with PT participants. At 6 weeks, when controlling for baseline group differences, greater pain self‐efficacy was the strongest predictor for reduced pain and higher function for the entire sample. A significant group interaction by baseline pain self‐efficacy predicted disability at 6 weeks. PT participants with low pain self‐efficacy reported significantly greater disability than those with high pain self‐efficacy. Yoga participants with low and high pain self‐efficacy had similar disability outcomes.ConclusionThese findings strengthen evidence that self‐efficacy is associated with cLBP outcomes, especially in individuals self‐selecting PT. Further research to evaluate outcomes after yoga and PT in participants with low pain self‐efficacy is needed.
Spinal Mobilization of Postpartum Low Back and Pelvic Girdle Pain: An Evidence‐Based Clinical Rule for Predicting Responders and Nonresponders
Authors: Al‐Sayegh Nowall A. , George Susan E. , Boninger Michael L. , Rogers Joan C. , Whitney Susan L. , Delitto Anthony 
Published: November 2010

ObjectiveTo develop a clinical prediction rule (CPR) for identifying postpartum women with low back pain (LBP) and/or pelvic girdle pain (PGP) whose functional disability scores improve with a high‐velocity thrust technique (HVTT) conducted by a physical therapist.DesignProspective cohort.SettingOutpatient physical therapy departments.ParticipantsSixty‐nine postpartum women referred to physical therapy with the complaint of LBP and/or PGP.MethodsSubjects underwent a physical examination and a HVTT to the lumbopelvic region.Main Outcome MeasuresSuccess with treatment was determined by the use of percent changes in disability scores and served as the reference standard for determining accuracy of the examination variables. Variables with univariate prediction of success and nonsuccess were combined into multivariate CPRs.ResultsFifty‐five subjects (80%) had success with the HVTT. A CPR for success with 4 criteria was identified. The presence of 2 of 4 criteria (positive likelihood ratio = 3.05) increased the probability of success from 80% to 92%. A CPR for treatment failure with 3 criteria was identified. The presence of 2 of 3 criteria (positive likelihood ratio = 11.79) increased the probability of treatment failure from 20% to 75%.ConclusionsThe pretest probability of success (80%) is sufficient to reassure the clinician about the decision to use a HVTT to the lumbopelvic region in postpartum women with LBP and/or PGP. If 2 of 3 criteria for treatment failure are met in the CPR, an alternative approach is warranted. An intervention such as the HVTT is compelling, given the need to minimize pharmaceutical remedies in women who are potentially breast‐feeding post partum.
Dimensionality of Measures for Severe Unilateral Ankle Arthritis
Authors: Cook Chad , Queen Robin M. , Slaven Emily J. , DeOrio James K. , Easley Mark E. , Nunley James A. 
Published: November 2010

ObjectiveTo analyze the dimensionality of 2 self‐report outcome measures (Foot/Ankle Disability Index [FADI] and Short‐Form [SF]‐36), 3 biomechanical measures (stance and step symmetry measures, gait speed, and step width), 2 physical‐performance measures (timed get‐up and go [TUG] and 4‐square step test [4SST]), and 1 clinician‐report outcome measure (American Orthopaedic Foot and Ankle Society [AOFAS] Hindfoot Scale) in a patient population with unilateral ankle arthritis. These measures captured the following functions: mobility and speed, pain and its relationship to function, social integration, and symmetry and efficiency of gait.DesignCase series design.SettingBiomechanical research laboratory adjacent to a busy orthopedic clinical practice.PatientsSeventy‐nine consecutive patients with unilateral traumatic arthritis who were candidates for a total ankle replacement.MethodsAn exploratory factor analysis with oblimin rotation was performed to determine the dimensions of the physical performance, biomechanical, self‐report, and clinician‐report measures.Main Outcome MeasurementsOutcomes measures included the SF‐36 and pertinent subscales, gait speed, the 4SST, the TUG, the FADI, the AOFAS Hindfoot Scale, and biomechanical measures of step width, step symmetry, and stance symmetry.ResultsFour distinct dimensions were captured during factor analysis. Factor 1 included the TUG, gait speed, the 4SST, and step width; factor 2 included the FADI, the SF‐36 bodily pain score, and the SF‐36 physical function score; factor 3 included the biomechanical scores of stance symmetry ratio and the step symmetry ratio; and factor 4 included SF‐36 social functioning and the AOFAS Hindfoot Scale.ConclusionsFindings suggest that various outcome measures for the ankle capture different dimensions and should be considered when evaluating the presence of disability or long‐term change in outcome.
Self-assembly of metal nanostructures on binary alloy surfaces
Authors: Duguet T. , Han Yong , Yuen Chad , Jing Dapeng , Ünal Barış , Evans J. W. , Thiel P. A. 
Published: November 2010

Deposition of metals on binary alloy surfaces offers new possibilities for guiding the formation of functional metal nanostructures. This idea is explored with scanning tunneling microscopy studies and atomistic-level analysis and modeling of nonequilibrium island formation. For Au/NiAl(110), complex monolayer structures are found and compared with the simple fcc(110) bilayer structure recently observed for Ag/NiAl(110). We also consider a more complex codeposition system, (Ni + Al)/NiAl(110), which offers the opportunity for fundamental studies of self-growth of alloys including deviations for equilibrium ordering. A general multisite lattice-gas model framework enables analysis of structure selection and morphological evolution in these systems.
Psychodynamic therapists' dilemmas in providing personal therapy to therapists in training: An exploratory study
Authors: King Gail 
Published: November 2010

AbstractAim: This study explores dilemmas facing psychodynamic therapists who provide personal therapy to therapists in training. Method: Eight experienced psychodynamic psychotherapists were interviewed using a semi‐structured interview format during which they were asked about the importance of personal therapy, if they encountered any dilemmas and, if so, how they resolved those dilemmas. Their responses were analysed using a qualitative form of content analysis. Findings: Two categories of dilemma emerged: clinical and personal. Clinical dilemmas arose out of the mandatory requirement for therapy, boundaries, fitness to practice and the suitability of trainees. Personal dilemmas included pressure to model, sense of responsibility, therapeutic narcissism, countertransference reactions, over‐use of self and stressful involvement. The therapists' strategies for resolving the dilemmas are described. Conclusion: The results show participants considered personal therapy to be essential for trainees and thought it should be mandatory even though it led to difficulties in the therapy. Questions arose about the suitability of some trainees, the person of the therapist and stressful involvement. Further research into these important areas is recommended.
Involvement of Arabidopsis RACK1 in Protein Translation and Its Regulation by Abscisic Acid
Authors: Guo Jianjun , Wang Shucai , Valerius Oliver , Hall Hardy , Zeng Qingning , Li Jian-Feng , Weston David J. , Ellis Brian E. , Chen Jin-Gui 
Published: November 2010

AbstractEarlier studies have shown that RACK1 functions as a negative regulator of abscisic acid (ABA) responses in Arabidopsis (Arabidopsis thaliana), but the molecular mechanism of the action of RACK1 in these processes remains elusive. Global gene expression profiling revealed that approximately 40% of the genes affected by ABA treatment were affected in a similar manner by the rack1 mutation, supporting the view that RACK1 is an important regulator of ABA responses. On the other hand, coexpression analysis revealed that more than 80% of the genes coexpressed with RACK1 encode ribosome proteins, implying a close relationship between RACK1’s function and the ribosome complex. These results implied that the regulatory role for RACK1 in ABA responses may be partially due to its putative function in protein translation, which is one of the major cellular processes that mammalian and Saccharomyces cerevisiae RACK1 is involved in. Consistently, all three Arabidopsis RACK1 homologous genes, namely RACK1A, RACK1B, and RACK1C, complemented the growth defects of the S. cerevisiae cross pathway control2/rack1 mutant. In addition, RACK1 physically interacts with Arabidopsis Eukaryotic Initiation Factor6 (eIF6), whose mammalian homolog is a key regulator of 80S ribosome assembly. Moreover, rack1 mutants displayed hypersensitivity to anisomycin, an inhibitor of protein translation, and displayed characteristics of impaired 80S functional ribosome assembly and 60S ribosomal subunit biogenesis in a ribosome profiling assay. Gene expression analysis revealed that ABA inhibits the expression of both RACK1 and eIF6. Taken together, these results suggest that RACK1 may be required for normal production of 60S and 80S ribosomes and that its action in these processes may be regulated by ABA.
Arabidopsis Transcription Factor ELONGATED HYPOCOTYL5 Plays a Role in the Feedback Regulation of Phytochrome A Signaling
Authors: Li Jigang , Li Gang , Gao Shumin , Martinez Cristina , He Guangming , Zhou Zhenzhen , Huang Xi , Lee Jae-Hoon , Zhang Huiyong , Shen Yunping , Wang Haiyang , Deng Xing Wang 
Published: November 2010

Abstract
Phytochrome A (phyA) is the primary photoreceptor responsible for perceiving and mediating various responses to far-red light in Arabidopsis thaliana. FAR-RED ELONGATED HYPOCOTYL1 (FHY1) and its homolog FHY1-LIKE (FHL) are two small plant-specific proteins essential for light-regulated phyA nuclear accumulation and subsequent phyA signaling processes. FHY3 and its homolog FAR-RED IMPAIRED RESPONSE1 (FAR1) are two transposase-derived transcription factors that directly activate FHY1/FHL transcription and thus mediate subsequent phyA nuclear accumulation and responses. Here, we report that ELONGATED HYPOCOTYL5 (HY5), a well-characterized bZIP transcription factor involved in promoting photomorphogenesis, directly binds ACGT-containing elements a few base pairs away from the FHY3/FAR1 binding sites in the FHY1/FHL promoters. We demonstrate that HY5 physically interacts with FHY3/FAR1 through their respective DNA binding domains and negatively regulates FHY3/FAR1-activated FHY1/FHL expression under far-red light. Together, our data show that HY5 plays a role in negative feedback regulation of phyA signaling by attenuating FHY3/FAR1-activated FHY1/FHL expression, providing a mechanism for fine-tuning phyA signaling homeostasis.
Amino Acid Homeostasis Modulates Salicylic Acid–Associated Redox Status and Defense Responses inArabidopsis
Authors: Liu Guosheng , Ji Yuanyuan , Bhuiyan Nazmul H. , Pilot Guillaume , Selvaraj Gopalan , Zou Jitao , Wei Yangdou 
Published: November 2010

AbstractThe tight association between nitrogen status and pathogenesis has been broadly documented in plant–pathogen interactions. However, the interface between primary metabolism and disease responses remains largely unclear. Here, we show that knockout of a single amino acid transporter, LYSINE HISTIDINE TRANSPORTER1 (LHT1), is sufficient for Arabidopsis thaliana plants to confer a broad spectrum of disease resistance in a salicylic acid–dependent manner. We found that redox fine-tuning in photosynthetic cells was causally linked to the lht1 mutant-associated phenotypes. Furthermore, the enhanced resistance in lht1 could be attributed to a specific deficiency of its main physiological substrate, Gln, and not to a general nitrogen deficiency. Thus, by enabling nitrogen metabolism to moderate the cellular redox status, a plant primary metabolite, Gln, plays a crucial role in plant disease resistance.
Sociable knowledge sharing online: philosophy, patterns and intervention
Authors: Matthews Paul , Stephens Rob 
Published: November 2010

PurposeThis paper seeks to outline a social epistemological and ethical warrant for engaging in knowledge exchange on the social web, and to emphasise socio‐cognitive and emotional factors behind motivation and credibility in communities supported by social software. An attempt is made to identify positive and negative patterns of interaction from this perspective and to argue for more positive intervention on the part of the information profession.Design/methodology/approachThe paper outlines social epistemological and related theory, cognitive and social drivers of behaviour and then draws together evidence to justify the definition of patterns that will be important to the project.Research limitations/implicationsA programme of evaluating online knowledge exchange behaviour using a social epistemological framework is needed. In order to do this, methodological development coupling formal epistemological with interpretive techniques for examining belief formation are also necessary.Practical implicationsConsiderations for the design and deployment of knowledge platforms and for engagement with existing communities are outlined.Social implicationsThe ideas presented attempt to define an important role for the information profession within a new paradigm of participation and social interaction online.Originality/valueThe connection between social epistemology theory and LIS has long been appreciated, but social epistemology is rarely applied to practice or to online social platforms and communities.