bluuebunny/crossref_metadata_2025_split huggingface dataset:
Integrated Transcriptome Analysis of Radioresistant Cells Revealed Genes and Pathways Predictive Of Tumor Response to Radiotherapy and Chemotherapy in Breast Cancer
Authors: Perez‐Añorve Isidro X. , Flores‐Fortis Mauricio , Patiño‐Morales Carlos C. , Ortiz‐Gutierrez Elizabeth , Del Moral‐Hernandez Oscar , Gonzalez‐De la Rosa Claudia H. , Soto‐Reyes Ernesto , Bonilla‐Moreno Raul , Chavez Saldaña Margarita , Landero‐Huerta Daniel A. , Ortega‐Bernal Daniel , Villegas Nicolas , Arechaga‐Ocampo Elena 
Published: June 2024

AbstractBreast cancer cells exposed to radiotherapy frequently develop radiation resistance through molecular and phenotypic changes. While there is evidences of pathways controlling radioresistance, the evolution of diverse cell phenotypes and transcriptional changes as mediators of radioresistance in breast cancer are restricted. Moreover, the effectiveness of the chemotherapy on radioresistant cells remains uncertain. In this work, an isogenic model of radioresistant breast cancer cells (RR cells) is used to study this phenotype. RR cells show high survival rates after radiation, moreover, RR cells of the triple negative breast cancer (TNBC) subtype show a significantly advanced invasiveness phenotype. Notably, RR cells are significantly sensitive to chemotherapy by inhibit cell survival and promote apoptosis. Transcriptomics and gene co‐expression network analysis identify differentially expressed genes (DEGs) and hub genes related to survival and apoptosis pathways in the RR cells of luminal subtype, while in TNBC subtype, cell migration, cell differentiation, and immune pathways are enriched. Hub genes predict the failure of radiotherapy in breast cancer patients, but they are also related to pathological complete response after chemotherapy. Transcriptome changes during acquired radioresistance uncover genes and pathways associated to radio and chemotherapy response. These results demonstrate that radioresistant pathways may converge to develop collateral chemo‐sensitivity.
Fluorinated Chitosan‐Mediated Transepithelial Delivery of Intravesical Dual‐Drug Immunotherapeutic for Bladder Cancer Therapy
Authors: Feng Lida , Huang Guixiao , Lei Qifang , Liang Mingkang , Deng Dashi , Liu Xiaocen , Kong Chenfan , Li Chenchen , Tan Xiyang , Li Guangzhi , Wu Song 
Published: June 2024

AbstractIntravesical instillation‐based immunotherapy for bladder‐preservation of bladder cancer (BCa) treatment has not been explored. In the current study, two irrigated nano‐formulations of immunological adjuvant‐fluorinated chitosan (FCS) and therapeutic antibody‐FCS are developed for synergistic immunotherapy against BCa. In this system, FCS is employed as a transepithelial carrier to assemble with bovine serum albumin (BSA)‐flubendazole (FBZ) complex and anti‐PD‐1 (αPD‐1) respectively, to facilitate efficient transepithelial delivery of intravesical FBZ‐BSA and αPD‐1 though transiently regulating the distribution of tight junction proteins on bladder epithelium. In addition, the FBZ–BSA complex exhibits tumor microenvironment‐responsive charge reversal and BSA carrier‐broken effects to drive tumor‐targeted dissociation and drug release of FBZ–BSA/FCS. Moreover, FBZ not only promotes apoptosis and inhibits glycolysis in cancer cells but also displays adjuvant properties to activate potent immune responses through IL‐12/IFN‐γ pathway. Interestingly, combined perfusion of FBZ–BSA/FCS and αPD‐1/FCS nano‐formulations can significantly activate the tumor immune microenvironment, especially CD8+ T cell infiltration and αPD‐1 sensitivity, and finally remarkably inhibit tumor growth in the mouse orthotopic BCa model. Thus, this study presents a novel intravesical delivery platform for ICB antibodies and a smart adjuvant system to achieve potent synergy immunotherapy, which is promising for bladder‐preserving treatment against BCa.
Determinants of macaques' space use: A test for the ecological constraints model using GPS collars
Authors: Xie Pu‐Zhen , Fan Yu‐Xuan , Chapman Colin , Ma Chi , Wu Cheng‐Feng , Hu Ping , Hu Liu‐Liu , Fan Peng‐Fei 
Published: June 2024

AbstractAs a central topic in Behavioral Ecology, animal space use involves dynamic responses to social and ecological factors. We collared 22 rhesus macaques (Macaca mulatta) from six groups on Neilingding Island, China, and collected 80,625 hourly fixes over a year. Using this high‐resolution location data set, we quantified the macaques' space use at the individual level and tested the ecological constraints model while considering various environmental and human interfering factors. As predicted by the ecological constraints model, macaques in larger groups had longer daily path lengths (DPLs) and larger home ranges. We found an inverted U‐shape relationship between mean daily temperatures and DPLs, indicating that macaques traveled farther on mild temperature days, while they decreased DPLs when temperatures were too high or too low. Anthropogenic food subsidies were positively correlated to DPLs, while the effect of rainfall was negative. Macaques decreased their DPLs and core areas when more flowers and less leaves were available, suggesting that macaques shifted their space use patterns to adapt to the seasonal differences in food resources. By applying GPS collars on a large number of individuals living on a small island, we gained valuable insights into within‐group exploitation competition in wild rhesus macaques.
Decentralized clinical trials for medications to reduce the risk of dementia: Consensus report and guidance
Authors: Howard Leanne , Abdelnour Carla , Abner Erin L. , Allegri Ricardo F. , Dodge Hiroko H. , Gauthier Serge , Hoyos Camilla M. , Jicha Gregory A. , Kehoe Patrick G. , Mummery Catherine J. , Ogunniyi Adesola , Scarmeas Nikolaos , Chen Xiaoying , Titiner Jodie R. , Weber Christopher R. ,   Clinical Trial Methodology Working review group members, Peters Ruth 
Published: June 2024

AbstractINTRODUCTIONRecent growth in the functionality and use of technology has prompted an increased interest in the potential for remote or decentralized clinical trials in dementia. There are many potential benefits associated with decentralized medication trials, but we currently lack specific recommendations for their delivery in the dementia field.METHODSA modified Delphi method engaged an expert panel to develop recommendations for the conduct of decentralized medication trials in dementia prevention. A working group of researchers and clinicians with expertise in dementia trials further refined the recommendations.RESULTSOverall, the recommendations support the delivery of decentralized trials in dementia prevention provided adequate safety checks and balances are included. A total of 40 recommendations are presented, spanning aspects of decentralized clinical trials, including safety, dispensing, outcome assessment, and data collection.DISCUSSIONThese recommendations provide an accessible, pragmatic guide for the design and conduct of remote medication trials for dementia prevention.Highlights
Clinical trials of medication have begun adopting decentralized approaches.
Researchers in the field lack guidance on what would be appropriate circumstances and frameworks for what would be appropriate circumstances and frameworks for the use of decentralized trial methods in dementia prevention.
The present report provides consensus‐based expert recommendations for decentralized clinical trials for dementia prevention.
The presenilin 1 mutation P436S causes familial Alzheimer's disease with elevated Aβ43 and atypical clinical manifestations
Authors: Arber Charles , Belder Christopher R. S. , Tomczuk Filip , Gabriele Rebecca , Buhidma Yazead , Farrell Clíona , O'Connor Antoinette , Rice Helen , Lashley Tammaryn , Fox Nick C. , Ryan Natalie S. , Wray Selina 
Published: June 2024

AbstractINTRODUCTIONFamilial Alzheimer's disease (fAD) is heterogeneous in terms of age at onset and clinical presentation. A greater understanding of the pathogenicity of fAD variants and how these contribute to heterogeneity will enhance our understanding of the mechanisms of AD more widely.METHODSTo determine the pathogenicity of the unclassified PSEN1 P436S mutation, we studied an expanded kindred of eight affected individuals, with magnetic resonance imaging (MRI) (two individuals), patient‐derived induced pluripotent stem cell (iPSC) models (two donors), and post‐mortem histology (one donor).RESULTSAn autosomal dominant pattern of inheritance of fAD was seen, with an average age at symptom onset of 46 years and atypical features. iPSC models and post‐mortem tissue supported high production of amyloid beta 43 (Aβ43). PSEN1 peptide maturation was unimpaired.DISCUSSIONWe confirm that the P436S mutation in PSEN1 causes atypical fAD. The location of the mutation in the critical PSEN1 proline‐alanine‐leucine‐proline (PALP) motif may explain the early age at onset despite appropriate protein maturation.Highlights
PSEN1 P436S mutations cause familial Alzheimer's disease.
This mutation is associated with atypical clinical presentation.
Induced pluripotent stem cells (iPSCs) and post‐mortem studies support increased amyloid beta (Aβ43) production.
Early age at onset highlights the importance of the PALP motif in PSEN1 function.
Antiferromagnetic Interactions through the Thirteen Å Metal–Metal Distances in Heterometallic One‐Dimensional Chains
Authors: Uemura Kazuhiro , Adachi Tomonori , Takamori Atsushi , Yoshida Michiyuki 
Published: June 2024

AbstractA heterometallic and paramagnetic one‐dimensional aligned chain in −Rh(+2)−Rh(+2)− Pt(+2)−Ni(+2)−Pt(+2)− with direct metal−metal bonds was obtained via HOMO–LUMO interactions at the σ* (dz2) orbital between [Rh2(O2CCH3)4] and [Pt2Ni(piam)4(NH3)4] (piam=pivalamidate). The one‐dimensional chains had straight backbones attributed to face‐to‐face stacking of each complex, and the Ni atoms were separated by approximately 13 Å from four different metals. Each Ni atom had two unpaired electrons in the d‐orbitals, which strongly exchanged with J=−37.9 cm−1 through the diamagnetic −Pt−Rh−Rh−Pt− bonds.
Adaptive memory event‐triggered fault‐tolerant dissipative control for networked T‐S fuzzy switched systems under denial‐of‐service attacks
Authors: Gao Hui , Ou Yongsheng , Wang Binrui , Shi Kaibo 
Published: June 2024

AbstractThis paper studied the problem of dissipative control for networked T‐S fuzzy switched systems under denial of service (DoS) attacks via a memory‐based adaptive event‐triggered mechanism. Since the system mode and controller mode do not match exactly, the asynchronous control is designed. The memory‐based adaptive event‐triggered mechanism can achieve better performance by using the historical data released. Though constructing a controller mode dependent Lyapunov functional, the dissipative performance of the closed‐loop system can be guaranteed. Finally, a numerical example is proposed to illustrate the superiority of the approach.
A systematic review of barriers to accessing cleft care worldwide
Authors: Cerón‐Zapata Ana María , Manrique‐Hernández Ruben Darío , Mejía‐Ortega Luz Mery 
Published: June 2024

AbstractPurposePatients with cleft lip/palate need an interdisciplinary approach. Delays in the care of these patients and difficulties in accessing health services have been reported in different low‐, middle‐, and high‐income countries. This study aimed to characterize worldwide publications on access to cleft lip and palate health treatment.MethodsDatabases were selected systematically and searched until July 2021. The review process followed standard methods for systematic reviews. The study quality was evaluated using the Strengthening the Reporting of Observational studies in Epidemiology guidelines for observational studies.ResultsA total of 289 publications were identified using our search strategy. After reviewing the titles and reading the abstracts and full text, 16 studies met the inclusion criteria in the review. In one study, financial difficulties obtained the attention of the professionals who attended to cleft lip/palate patients. Ethnic disparities, problems in transportation, and long distances between users and health centers were found. Additionally, there was misinformation about treatment and follow‐up among the caregivers of patients with cleft lip/palate.ConclusionWhen reviewing the literature on access to health services for patients with cleft lip/palate, barriers were reported in access to information, physical access to care centers, financial resources to cover expenses for treatment, and opportunities in care.
Cultural distance and bilateral trade: A transitional economy perspective
Authors: Mostafiz Fahmida , Akter Mansura , Rahman Mahfuzur 
Published: June 2024

AbstractCultural differences represent significant trade barriers between transitional economies and their trading partners, which has been overlooked in recent studies. This paper investigates the effect of cultural distance (CD) on bilateral trade from Bangladesh. We conceptualize a research model by employing the extended gravity model as a theoretical base, where we amplify the theory by proposing that linguistic distance (LD) as a part of cultural distance has a profound effect on bilateral trade based on bilateral trade data from 1995 to 2019 and Hofstede's culture indices between Bangladesh and 157 trading partner countries. Using a pseudo‐poisson maximum likelihood model, we find that cultural distance has a significant and negative impact on Bangladesh's trade, with a significance level of 1%. Our empirical results indicate that one unit increase in cultural distance decreases trade by 40.84% and cultural distance has a greater impact on Bangladesh's exports than on its imports. Findings also reveal that the effect is substantial with high‐income nations than with low‐income nations, and for manufacturing products than primary products trade. Further, this study suggests that in addition to cultural distance (CD), linguistic distance (LD) from trading partners has a tantamount effect on bilateral trade, which is significant at 1%. Theoretically, this study suggests that linguistic distance (LD) should be added on gravity model for analyzing effects of cultural distance on bilateral and multilateral trade. Practically, this study contributes by providing valuable insights to policymakers to pay attention to cultural differences, especially during these economic transition periods to increase bilateral trade.
The ISO 14001 standard's effect on agrifood small‐ and medium‐sized enterprises' performance: Literature review and empirical evidence
Authors: Labella Rocio Carrillo , Fort Fatiha , Parras Rosa Manuel 
Published: June 2024

AbstractA significant part of the literature postulates the importance of economic factors and, in particular, market pressure as the main motivation for the adoption of environmental management systems, such as ISO 14001 (International Organization for Standardization). Most of these studies are based on questionnaire surveys assessing the perceptions or opinions of company managers. Few studies have investigated the relationship between the adoption of the standard and economic and financial performance using objective accounting data. This study aimed to test the link between ISO 14001 adoption and economic and financial performance using accounting data from 374 agrifood small‐ and medium‐sized enterprises (SMEs) in Spain during the period 2013 to 2015. The results showed that ISO 14001 contributes to improved commercial and marketing performance through a positive effect on turnover in domestic markets and especially in export markets. However, no positive relationship could be found between ISO14001 and company results or profits. Therefore, ISO 14001 can be considered more as a means of entering and developing sales, particularly in export markets, than a tool to enhance financial profits.
Environmental innovation and takeover performance
Authors: Hussain Tanveer , Tunyi Abongeh A. , Areneke Geofry 
Published: June 2024

AbstractDrawing from the resource‐based view (RBV), we examine the effect of environmental innovation on mergers and acquisitions (M&As) announcement returns. Using an international sample of M&As for the period of 2003–2021 and an event study methodology, we document that acquirers with higher environmental innovation—innovative acquirers—earn average deal announcement abnormal returns that are 0.10–0.50 percentage points higher than those earned by their non‐innovative counterparts. These results are consistent across three important forms of environmental innovation (i.e., product, process, and organizational innovation) and are partly explained by the transfer of environmental innovation from the acquirer to the target. We further find that environmentally innovative acquirers are more likely to engage in majority control and cross‐border acquisitions, thus emphasizing the transfer effect. Overall, we contribute to RBV by providing evidence that environmental innovation is a distinctive resource or dynamic capability that is transferable from bidders to targets in the takeover market.
Peripheral blood mononuclear cells show markers of mitochondrial dysfunction in rheumatoid arthritis
Authors: Abbasifard Anahita , Solgi Ghasem , Khodadadi Iraj , Doosti‐Irani Amin , Tayebinia Heidar , Fazaeli Alireza 
Published: June 2024

AbstractRheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease. Metabolic and mitochondrial dysregulation are critical causal factors in the pathogenesis and progression of RA. Mitochondrial dysfunction include abnormal energy metabolism, and excessive production of reactive oxygen species (ROS). This study aimed to investigate the adenosine triphosphate (ATP), mitochondrial membrane potential (ΔΨm), ROS, and mRNA expression level of ROMO1 (as ROS modulator) and OMA1 (as regulator mitochondrial dynamics) of peripheral blood mononuclear cells (PBMC) in RA patients. The study participants were 50 patients with RA and 50 sex‐ and age‐matched healthy volunteers. PBMC of all participant were isolated by Ficoll‐Paque. Alteration in ΔΨm and cellular ROS were measured using flow cytometry, ATP level was also assessed via luminometry, and ROMO1 and OMA1 mRNA expression via qRT‐PCR assay. A significant decrease in ATP (p = .005) and ΔΨm (p < .001) was observed in the PBMC of RA compared to control. The ROS levels were significantly higher in the PBMC of RA compared to the control (p < .001). ROMO1 and OMA1 mRNA expression was also significantly increased in RA patients compared to control (p < .001). The decrease in ATP is strongly associated with ROS increasing in PBMC of RA patients, denoting an inverse and negative relationship between ATP and ROS production. Also, a decrease in ΔΨm was observed. It seems that in line with mitochondrial dysfunction in PBMC, increased expression of ROMO1 and OMA1 genes could also be involved in the development of RA.
Hemicyanine‐Based Highly Water‐Soluble Probe for Extracellular Nitroreductase
Authors: Jiang Shaoli , Xu Le , Zhong Yihong , Zhang Chuangchuang , Yu Xiaoyu , Li Ke , Ding Lin , Wang Xiaojian 
Published: June 2024

AbstractNitroreductase (NTR) has long been a target of interest for its important role involved in the nitro compounds metabolism. Various probes have been reported for NTR analysis, but rarely able to distinguish the extracellular NTR from intracellular ones. Herein we reported a new NTR sensor, HCyS‐NO2, which was a hemicyanine molecule with one nitro and two sulfo groups attached. The nitro group acted as the reporting group to respond NTR reduction. Direct linkage of nitro group into the hemicyanine π conjugate system facilitated the intramolecular electron transfer (IET) process and thus quenched the fluorescence of hemicyanine core. Upon reduction with NTR, the nitro group was rapidly converted into the hydroxylamino and then the amino group, eliminating IET process and thus restoring the fluorescence. The sulfo groups installed significantly increased the hydrophilicity of the molecule, and introduced negative charges at physiological pH, preventing the diffusion into bacteria. Both gram‐negative and gram‐positive bacteria were able to turn on the fluorescence of HCyS‐NO2, without detectable diffusion into cells, providing a useful tool to probe the extracellular reduction process.
Experimental and Computational Fluid Dynamics Analysis of Industrial Water Desalination with High Salinity by Adsorption Chlorine on Resin in a Packed Column
Authors: Mahmoodabadi Hamideh , Soltani Goharrizi Ataallah 
Published: June 2024

AbstractTo investigate chlorine adsorption from water onto resins, some batch adsorption tests were considered. The mechanisms and characteristic parameters of the adsorption process were analyzed using isotherm models which revealed the following order (based on the coefficient of determination): Flory–Huggins (0.99) > Fowler‐Guggenheim (0.98) >, and Langmuir (0.38).The experimental data were examined using two kinetic models, including first‐ and second‐order ones with R2 value of 0.88, 0.1 respectively. According to the adsorption isotherm study, the Flory–Huggins isotherm model better fit adsorption on the surface of resin, as compared to other models. Assessing the thermodynamic parameters found out that the adsorption of Cl onto resins became an exothermic and spontaneous process. The results were then obtained. Similarly, the results of the experiment were provided via the computational fluid dynamics evaluation. Moreover, the results obtained by computational fluid dynamics were compared with the experimental data, and their accuracy was proved. Subsequently, the effects of changing the design and operating parameters, including flow rate (3, 6, 10 L min−1) and bed height (10, 20, 40 cm) on the performance of this tower were studied. The results showed that by reducing the adsorbent, the adsorbed Cl increased and a longer bed was required for adsorption, which was not cost‐effective. The amount of adsorption decreased as the flow rate increased, indicating that there was little contact between the Cl and the adsorbent.
Examining Invasion‐Percolation Across the Cathode Layered Assembly in Polymer Electrolyte Membrane Fuel Cells: Oxygen Resistance, Wettability and Cracks
Authors: García‐Salaberri Pablo A. 
Published: June 2024

AbstractEfficient evacuation of water generated by oxygen reduction reaction is necessary to increase catalyst utilization in polymer electrolyte membrane Fuel Cells. However, analysis of two‐phase transport is challenged by the wide range of pore sizes present in the membrane electrode assembly (MEA), varying from 10–100 nm in the catalyst layer (CL), 10–1000 nm in the microporous layer (MPL) and 10 μm in the gas diffusion layer (GDL). In this work, a novel multiscale invasion‐percolation model accounting for the cathode CL, MPL and GDL is presented. Saturation in the macroporous GDL is modeled through an all‐or‐nothing invasion law (empty/filled), while a macroscopic description in terms of the capillary pressure curve is adopted for the MPL and the CL. The oxygen transport resistance across the cathode MEA is quantified using the computed saturation distributions. Among other conclusions, the results show that MPL addition is crucial to avoid local flooding at the CL/GDL interface, providing localized access points to the GDL rather than massively invading interfacial macropores. However, excessive MPL hydrophobicity can cause CL flooding. Water removal from the CL can be enhanced by using a more hydrophilic MPL, a hydrophobic CL or the addition of a moderate volume fraction of cracks. Oxygen transport can be further improved by modulating the arrangement of water in the GDL with patterned wettability, provided that the number of MPL cracks is low.