bluuebunny/crossref_metadata_2025_split huggingface dataset:
Analysis of landslide susceptibility and potential impacts on infrastructures and settlement areas (a case from the southeastern region of Türkiye)
Authors: Gokceoglu Candan , Karakas Gizem , Tunar Özcan Nazlı , Elibuyuk Aziz , Kocaman Sultan 
Published: May 2024

AbstractLandslides have harmful effects not only on buildings but also on infrastructure and the natural environment. While they are typically triggered by natural events, such as heavy rainfalls and earthquakes, landslides can also be induced by anthropogenic activities, such as excavation and blasting. In certain regions, gigantic paleo-landslides exist, but triggering them is extremely difficult. However, triggering secondary landslides in gigantic paleo-landslides is relatively easy compared to the main corpus. The main purpose of this study was to produce a susceptibility map in a region in southeastern Türkiye and to discuss the impact of petroleum seismological investigation concerning the trigger of the landslides. For this purpose, a landslide inventory was compiled using geospatial data sets and field observations and used for landslide susceptibility mapping with the Random Forest algorithm. The accelerations sourced from blasting were also measured and the run-out distances were determined. A run-out distance map was produced using inverse distance weights. The study presents comprehensive insights by integrating a landslide susceptibility map and run-out distance map. It evaluates the impact of blasting on landslides through in-situ measurements and slope stability analyses. Findings indicate that no triggering effect on landslides was observed if the dynamite quantity remains below 4 kg and the blasting distance exceeds 10 m from the landslide.
Hydrochemistry and isotope hydrology of groundwater and surface water in the Sor and Gebba watershed, southwestern Ethiopia
Authors: Bayou Wondmyibza Tsegaye , Mohammed Mebruk , Ayenew Tenalem , Mebrahtu Tesfay Kiros , Wohnlich Stefan 
Published: May 2024

AbstractThe Sor and Gebba watershed plays a crucial role in the water resources of the Baro-Akobo River Basin. However, various factors have had a detrimental effect on the watershed. Unplanned groundwater extraction, wetland drainage, surface water pollution, and land use changes have all intensified due to population growth, urbanization, commercial farms, industrial development, poor water resources management, and improvements in living standards. This research utilized major hydrochemical ions and environmentally stable isotopes to elucidate the interaction between groundwater and surface water in the watershed, which are reliable tracers in various hydrologic processes. During the 2020 wet season and 2022 dry season, over 25 meteoric water samples were collected from different locations for hydrochemical and isotopic analysis. The hydrochemical analysis revealed that the dominant water type is Ca–Mg–HCO3−. Among the anions, HCO3− was the most dominant, followed by NO3−, Cl−, and SO42−, and those of cations Ca2+, followed by Na+, Mg2+, and K+. The spatial analysis of environmentally stable isotopes confirmed the interaction between groundwater and surface water in the watershed. The quality of groundwater is primarily influenced by rock-water interaction (Gibb's diagram) and, to some extent, by evaporation (Isotope study). A graph of the water samples closely aligned with the Addis Ababa-local meteoric water line indicates their meteoric origin. However, there was a slight deviation to the left due to the effects of distance and altitude. The isotopic correlation further supported the interaction between different water sources.
Hsp90α and cell death in cancers: a review
Authors: Liu Bin , Qian Daohai 
Published: May 2024

AbstractHeat shock protein 90α (Hsp90α), an important molecular chaperone, plays a crucial role in regulating the activity of various intracellular signaling pathways and maintaining the stability of various signaling transduction proteins. In cancer, the expression level of Hsp90α is often significantly upregulated and is recognized as one of the key factors in cancer cell survival and proliferation. Cell death can help achieve numerous purposes, such as preventing aging, removing damaged or infected cells, facilitating embryonic development and tissue repair, and modulating immune response. The expression of Hsp90α is closely associated with specific modes of cell death including apoptosis, necrotic apoptosis, and autophagy-dependent cell death, etc. This review discusses the new results on the relationship between expression of Hsp90α and cell death in cancer. Hsp90α is frequently overexpressed in cancer and promotes cancer cell growth, survival, and resistance to treatment by regulating cell death, rendering it a promising target for cancer therapy.
The cost of genetic diagnosis of suspected hereditary pediatric cataracts with whole-exome sequencing from a middle-income country perspective: a mixed costing analysis
Authors: Neves Luiza M. , Pinto Márcia , Zin Olivia A. , Cunha Daniela P. , Agonigi Bruna N. S. , Motta Fabiana L. , Gomes Leonardo H. F. , Horovitz Dafne D. G. , Almeida Daltro C. , Malacarne Jocieli , Guida Leticia , Braga Andressa , Carvalho Adriana Bastos , Pereira Eduardo , Rodrigues Ana Paula S. , Sallum Juliana M. F. , Zin Andrea A. , Vasconcelos Zilton F. M. 
Published: May 2024

AbstractUp to 25% of pediatric cataract cases are inherited. There is sparse information in the literature regarding the cost of whole-exome sequencing (WES) for suspected hereditary pediatric cataracts. Molecular diagnosis of suspected hereditary pediatric cataracts is important for comprehensive genetic counseling. We performed a partial economic evaluation with a mixed costing analysis, using reimbursement data and microcosting approach with a bottom-up technique to estimate the cost of using WES for genetic diagnosis of suspected hereditary pediatric cataracts from the perspective of the Brazilian governmental health care system. One hundred and ten participants from twenty-nine families in Rio de Janeiro (RJ) were included. Costs of consumables, staff and equipment were calculated. Two scenarios were created: (1) The reference scenario included patients from RJ with suspected hereditary pediatric cataracts plus two family members. (2) The alternative scenario considered other genetic diseases, resulting in 5,280 exams per month. Sensitivity analysis was also performed. In the reference scenario, the total cost per exam was 700.09 United States dollars (USD), and in the alternative scenario, the total cost was 559.23 USD. The cost of WES alone was 527.85 USD in the reference scenario and 386.98 USD in the alternative scenario. Sensitivity analysis revealed that the largest costs were associated with consumables in both scenarios. Economic evaluations can help inform policy decisions, especially in middle-income countries such as Brazil.
Sexual and Mental Health in Healthcare Workers during the COVID-19 Outbreak: Exploring the Role of Meaning-Centered Coping
Authors: Pérez-Escobar José Antonio , Carreno David F. , Pérez-Escobar Rosalía , Eisenbeck Nikolett 
Published: May 2024

Abstract
Introduction
The acute phase of the COVID-19 pandemic impacted the sexual function and mental health of healthcare workers worldwide. However, the extent to which sexual health, including its relational dimension, was affected among different healthcare services and the protective coping strategies employed at that time is currently unclear. The present study aimed to investigate these two issues, exploring for the first time the role of meaning-centered coping on sexual health.

Method
The sample consisted of 109 healthcare workers divided into two groups: a high-exposure group (Intensive Care Unit service, 63 participants) and a low-exposure group (gynecology, obstetrics, and pediatrics services, 46 participants). One year after the onset of the COVID-19 pandemic, participants completed an online survey comprised of sociodemographic and COVID-19 exposure variables, the Depression Anxiety and Stress Scale, the New Sexual Satisfaction Scale-Short Form, and the Meaning-Centered Coping Scale.

Results
(1) High-exposure participants reported more anxiety and depressive symptoms, (2) anxiety, depression and stress were associated with decreased sexual health after the pandemic, (3) High-exposure participants reported a higher decrease in their sexual health, (4) High-exposure workers reported higher levels of meaning-centered coping, and (5) higher levels of meaning-centered coping predicted higher sexual health in both groups.

Policy Implications
Various healthcare services pose distinct risks regarding the detrimental effects of collective health crises on mental and sexual health, and therefore they should be differently treated. The promotion of meaning-centered coping is a sensible policy to improve preparedness in healthcare contexts, especially in vulnerable services and subpopulations.
Digital twins in aircraft production and MRO: challenges and opportunities
Authors: Moenck Keno , Rath Jan-Erik , Koch Julian , Wendt Arne , Kalscheuer Florian , Schüppstuhl Thorsten , Schoepflin Daniel 
Published: May 2024

AbstractThe digital twin (DT) concept, value-adding connecting the real and digital world, has been a rising trend in recent years, while the implementation and observation of challenges are still subject to research. Implementations of holistic Digital Twins of tangible and intangible assets of complex products or processes are often ideal-theoretic; instead, only subsystems and processes are replicated, which digital representations serve specific, meaningful applications. Specifically, with its distinct characteristics, the aviation industry and its production show various future application scenarios, which we use case-driven outline in this work. Therefore, we first summarize common, industry-neutral challenges of implementing Digital Twins and give an overview of aircraft production characteristics. Then, we will outline different fields of utilizing the Digital Twin concept and highlight integrational, organizational, and compliance-related challenges as well as opportunities in the context of aircraft production and Maintenance, Repair, and Overhaul (MRO). The use cases are located at different aircraft life cycle phases, from production system development, production supplying logistics, and Quality Assurance (QA) up to retrofit.
Preparation and Characterization of Amoxicillin-Loaded Polyvinyl Alcohol/Sodium Alginate Nanofibrous Mat: Drug Release Properties, Antibacterial Activity, and Cytotoxicity
Authors: Çerçi Azize , Demir Elif Sena , Karaca Esra , Güzel Çağla Bozkurt , Osman Bilgen 
Published: May 2024

AbstractThis study aimed to prepare a polyvinyl alcohol/sodium alginate (PVSA) nanofibrous mat as an amoxicillin (AMOX) delivery system. AMOX was loaded to the PVSA nanofibers during electrospinning, and the AMOX-loaded PVSA (PVSA/AMOX) nanofibrous mat was cross-linked by glutaraldehyde (GA). The PVSA/AMOX nanofibrous mat was characterized by Fourier Transform infrared spectroscopy, scanning electron microscopy, Brunauer–Emmett–Teller, and mercury porosimetry analyses. The thickness, air permeability, and water vapor transmission rate of the PVSA/AMOX nanofibrous mat were 0.43 ± 0.08 mm, 17.2 ± 4.91 L/m2/s, and 1485 ± 13.6 g/m2/d, respectively, which were suitable for wound dressing applications. The tensile strength was 6.73 ± 0.48 MPa and elongation at a maximum load was 81.9 ± 17.0%, within the ranges of human skin’s values. The total porosity was 59.4%, enabling cell adhesion, migration, and proliferation. The PVSA/AMOX nanofibrous mat has high swelling (319 ± 4.2%) and low degradation (2.2 ± 0.1% in 10 days) ratios. The nanofibrous mat cross-linked with 0.25% GA solution for 20 min had a 73.07% cumulative release for 90 min. The drug release kinetics were obeyed to the Korsmeyer-Peppas model. The nanofibrous mat presented antibacterial activity on S. aureus ATCC 29213 and E. coli ATCC 25922, and there was no cytotoxic effect on the human normal keratinocyte cells, demonstrating the potential for use in wound dressing applications.
Optimal annuitisation, housing and reverse mortgage in retirement in the presence of a means-tested public pension
Authors: Andréasson Johan G. , Shevchenko Pavel V. 
Published: May 2024

AbstractIn this paper we develop a model to find optimal decisions in retirement with respect to the consumption, risky asset allocation, access to annuities, reverse mortgage and the option to scale housing in the presence of a means-tested public pension. To solve the corresponding high-dimensional optimal stochastic control problem, we use the Least-Squares Monte Carlo simulation method. The model is applied in the context of the Australian retirement system. Few retirees in Australia utilise financial products in retirement, such as annuities or reverse mortgages. Since the government-provided means-tested Age Pension in Australia is an indirect annuity stream which is typically higher than the consumption floor, it can be argued that this could be the reason why many Australians do not annuitise. In addition, in Australia where assets allocated to the family home are not included in the means tests of Age Pension, the incentive to over-allocate wealth into housing assets is high. This raises the question whether a retiree is really better off over-allocating into the family home, while accessing home equity later on either via downsizing housing or by taking out a reverse mortgage. Our findings confirm that means-tested pension crowds out voluntary annuitisation in retirement, and that annuitisation is optimal sooner rather than later once retired. We find that it is never optimal to downscale housing when the means-tested pension and a reverse mortgage are available; only when there is no other way to access equity then downsizing is the only option.
Generalized fractional derivatives generated by Dickman subordinator and related stochastic processes
Authors: Gupta Neha , Kumar Arun , Leonenko Nikolai , Vaz Jayme 
Published: May 2024

AbstractIn this article, convolution-type fractional derivatives generated by Dickman subordinator and inverse Dickman subordinator are discussed. The Dickman subordinator and its inverse are generalizations of stable and inverse stable subordinators, respectively. The series representations of densities of the Dickman subordinator and inverse Dickman subordinator are also obtained, which could be helpful for computational purposes. Moreover, the space and time-fractional Poisson-Dickman processes, space-fractional Skellam Dickman process and non-homogenous Poisson-Dickman process are introduced and their main properties are studied.
Natural-derived acetophenones: chemistry and pharmacological activities
Authors: Ahmadpourmir Hamid , Attar Homayoun , Asili Javad , Soheili Vahid , Taghizadeh Seyedeh Faezeh , Shakeri Abolfazl 
Published: May 2024

AbstractAcetophenones are naturally occurring phenolic compounds which have found in over 24 plant families and also fungi strains. They are exist in both free or glycosides form in nature. The biological activities of these compounds have been assayed and reported including cytotoxicity, antimicrobial, antimalarial, antioxidant and antityrosinase activities. Herein, we review the chemistry and biological activity of natural acetophenone derivatives that have been isolated and identified until January 2024. Taken together, it was reported 252 acetophenone derivatives in which the genera Melicope (69) and Acronychia (44) were the principal species as producers of acetophenones.
Graphical Abstract
Occult hepatitis B infection in children born to HBeAg-positive women confers a low long-term risk for HBsAg-positive infection
Authors: Eilard Anders , Andersson Maria E. , Wejstål Rune , Norkrans Gunnar , Lindh Magnus 
Published: May 2024

Abstract
Purpose
Mother-to-child transmission (MTCT) has been the main cause of chronic hepatitis B virus (HBV) infection, particularly in East Asia. Hepatitis B immunoglobulin (HBIG) and vaccination given directly after birth effectively prevents hepatitis B surface antigen (HBsAg)-positive (overt) HBV infection, but occult hepatitis B infection (OBI) may develop despite adequate prophylaxis. The aim of this study was to investigate the long-term outcome in children born to mothers with very high HBV DNA levels with special focus on children discovered in early childhood with OBI.

Methods
One-year and long-term outcome regarding overt and occult HBV infection were analysed in 66 children born to hepatitis B e antigen (HBeAg)-positive mothers, and were compared with one-year outcome in 69 children born to HBeAg-negative mothers. The children were born between 1998 and 2018.

Results
Six children born to HBeAg-positive mothers developed overt chronic HBV infection, in two cases after normal pregnancies and despite HBIG and vaccination, but never when nucleotide analogue treatment was given during pregnancy. OBI with HBV DNA detected in serum in the absence of surface antigen (HBsAg) was observed in four children at the age of 1 year. One of them was transiently HBsAg-positive at the age of 7 years. At long-term follow-up, six children had overt chronic infection, one had OBI and six had previous OBI or positive anti-HBc suggesting resolved unidentified infections.

Conclusion
The results indicate that children born to mothers with high HBV DNA levels have approximately 10% risk to develop OBI despite antiviral treatment, vaccination and HBIG, but that such OBI confers a minimal long-term risk for overt infection, at least in immunocompetent children.
Group-Based Interventions for Adolescents with Gaming Disorder or Problematic Gaming Behavior: A Systematic Review
Authors: Boonen Huub , Vanderplasschen Wouter , Sinclair Deborah L. , Flayelle Maèva , Billieux Joël 
Published: May 2024

Abstract
Purpose of Review
Although gaming disorder (GD) is prevalent during adolescence and group-based interventions (GBIs) prove highly beneficial for substance use disorders, much remains unknown regarding their utility for addressing problematic gaming (PG) and GD. This systematic review thus explores the potential value of GBIs for adolescents with PG/GD.

Recent Findings
With the inclusion of PG/GD as a potential diagnosis by the American Psychiatric Association in 2013 and the acceptance of GD as a psychological disorder by the World Health Organization in 2019, research on this topic has proliferated. Although reviews to date have accorded attention to cognitive behavioral therapy, technology-based interventions, or focused on broader conditions such as “Internet addiction,” none has exclusively focused on GBIs or adolescent populations.

Summary
The findings from the eight retained studies suggest a positive impact of GBIs on adolescent PG/GD. Nonetheless, the particular benefits of “the group” as a modality remained largely unaddressed. Future research should adopt more rigorous designs to understand its underlying mechanisms.
Soziale Eingebundenheit im individualisierten Unterricht: Eine Experience-Sampling Studie
Authors: Ohl Simon , Dumont Hanna 
Published: May 2024

ZusammenfassungDas Bedürfnis nach sozialer Eingebundenheit gilt als fundamentales Motiv menschlichen Handelns und ist auch für das schulische Lernen von Bedeutung. In einem individualisierten Unterricht, der sich durch einen hohen Anteil selbstgesteuerter Einzelarbeit und eine starke Ausdifferenzierung von Methoden, Materialien und Aufgaben auszeichnet, könnte es sich als Herausforderung gestalten, alle Schüler:innen sozial einzubinden. Ein an den Schüler:innen orientierter individualisierter Unterricht sollte jedoch sowohl die unterschiedlichen Lernvoraussetzungen wie auch das Bedürfnis nach sozialer Eingebundenheit der Schüler:innen im Blick haben. Die vorliegende Studie setzt hier an und untersucht anhand der Experience-Sampling-Methode, inwiefern die Schüler:innen sich im individualisierten Unterricht an Grundschulen, die den Deutschen Schulpreis gewonnen haben, sozial eingebunden fühlen und ob dies mit einer individualisierten Unterrichtsgestaltung auf der Oberflächenstruktur des Unterrichts (Differenzierung der Aufgaben, autonome Aufgabenbearbeitung und selbstgesteuertes Lernen) und Merkmalen der Tiefenstruktur des Unterrichts (kognitive Aktivierung, Klassenführung, konstruktive Unterstützung und Gemeinschaftsgefühl) zusammenhängt. Dazu wurden 237 Schüler:innen der dritten und vierten Jahrgangsstufe aus 22 Klassen mit Tablet-Computern ausgestattet und über eine Woche hinweg durchschnittlich ~10,12-mal nach einer Unterrichtsstunde gefragt, wie wohl sie sich mit ihren Mitschüler:innen fühlten, um die situative soziale Eingebundenheit zu erfassen. Die Lehrkräfte entschieden dabei selbst, wann die Testung durchgeführt wurde. Zunächst wurde untersucht, inwiefern die soziale Eingebundenheit innerhalb und zwischen Schüler:innen sowie zwischen Unterrichtsstunden und zwischen Klassen variiert. Es zeigte sich, dass die meiste Varianz innerhalb und zwischen Schüler:innen lag. Darüber hinaus konnten positive Zusammenhänge zwischen der sozialen Eingebundenheit und Merkmalen einer individualisierten Unterrichtsgestaltung (autonome Aufgabenbearbeitung) sowie Merkmalen der Unterrichtsqualität (konstruktive Unterstützung und Gemeinschaftsgefühl) auf Ebene der Schüler:innen sowie der Klassen gefunden werden. Die Studie liefert erste Erkenntnisse über die Variabilität der sozialen Eingebundenheit im individualisierten Unterricht und hebt die Bedeutung einer positiven Beziehung zwischen der Lehrkraft und den Schüler:innen sowie den Schüler:innen untereinander hervor.
Parametric Dynamic Simulation and Bayesian Design Optimization of a Front-Loading Washing Machine
Authors: Hashemian Fatemeh , Yang Haizhou , Wang Yi , Deng Xiaomin , Kim Seungoh , Vaidhyanathan Raveendran 
Published: May 2024

Abstract
Objective
This paper presents the dynamic modeling and design optimization of a fully parametrized front-loading washing machine.

Methods
A thorough mathematical analysis is performed to capture the effect of nine design variables (including rotation speed, spring stiffness, weight balancer mass density, damping coefficient, spring and damper angles) on vibrational characteristics of the washing machine. The parametric simulation reveals a complex relationship between the vibrational dynamics and design variables, entailing a computationally efficient optimization approach. A Bayesian Optimization (BO) framework is developed, in which a Gaussian process model and Genetic Algorithm (GA) are utilized along with carefully selected acquisition functions to enable adaptive sampling and search for optimal design values. The objective function is to minimize the maximum amplitude of the tub displacement inside the washing machine body. Two case studies are performed to consider a different number of design variables and choices of various infill methods.

Results
Results show that the fully parametrized front-loading washing machine model is applicable for parametric simulation and design optimization. The proposed BO is able to successfully find a set of design variable values corresponding to the lowest maximum displacement for vibration reduction. A comparison analysis is also carried out to exhibit the difference in optimization convergence and computational cost caused by the choice of acquisition functions.

Conclusion
It is shown that the fully parametrized washing machine model yields a lower maximum displacement than the model with fewer design variables. Of the two acquisition functions studied for optimization, the Expected Improvement function converges more rapidly than the Lower Bound criterion.