bluuebunny/crossref_metadata_2025_split huggingface dataset:
120: THE CLINICAL EFFECTIVENESS AND COST-EFFECTIVENESS OF FRACTIONAL CO2 LASER IN ACNE SCARS AND SKIN REJUVENATION: A SYSTEMATIC REVIEW AND ECONOMIC EVALUATION
Authors: Yaaghoobian Barmak , Sadeghi-Ghyassi Fatemeh , Hajebrahimi Sakineh 
Published: May 2024

Background and aims:Skin rejuvenation is one of high demand cosmetic interventions in Iran. Fractional CO2 Laser is a high power ablative laser which has variety of utilization in medicine including treatment of acne scars and rejuvenation. The aim of this study was to evaluate the safety, efficacy, and cost-effectiveness of Fractional CO2 Laser in comparison with other methods of rejuvenation and acne scar treatment.Methods:A systematic database search including Medline (via OVID and PubMed), EMBASE, CINHAL, Cochrane Library, CRD, SCOPUS and Web of Science conducted. After screening search results, selected publications appraised by CASP and Cochrane Collaboration's tool for assessing risk of bias and eligible studies included in the systematic review. In economic evaluation, all costs and benefits analyzed from Iran ministry of health's perspective.Results:From 2667 publications, two randomized control trials were eligible and included in the study. The affectivity and complications of Fractional CO2 laser were comparable with Er: YAG but Fractional CO2 laser was 14.7% (P=0.01) more effective than Q-Switched ND: YAG laser. Cost affectivity of this method was the same as other alternative lasers.Conclusions:Fractional CO2 laser is an effective and safe method for curing several kinds of skin. Never the less there was not sufficient evidence to support its advantage. This device has equal or lower price in comparison to competent technologies except for the non- fractional ablative Co2 laser that has the same or lower price and comparable effects.
128: THE EFFECT OF INTRAMUSCULAR HYOSCINE AND HYOSCINE-PROMETHAZINE ON THE DURATION OF LABOR IN NULLIPAROUS PREGNANT WOMEN (TRIPLE-BLIND RANDOMIZED CONTROLLED TRIAL)
Authors: Shafahi Fahimeh Sehhatie , Shahmohammadi Farzeneh , Khanmohammadi Fatemeh , Jaffarabadi Mohamad Ashari 
Published: May 2024

Background and aims:Improvement of maternal healthiness and decreasing maternal mortality and morbidity is one of important anxieties in the world. One of the factors that influence intensity of pain is duration of labor. In other words, increasing intensity of pain affects duration of labor. This study survey the effect of intramuscular Hyoscine and Hyoscine-Promethazine on the duration of labor in nulliparous pregnant women.Methods:This study was three blind clinical trials on 213 nulliparous pregnant women who have referred to Amiralmomenin hospital in Zanjan. Selection of samples was random and done with Rand List software and used 3, 6 (1:1:1) of blocking size. This study had 3 groups. First group received 20 mg Hyoscine(A), second group 20mg Hyoscine and 25mg Promethazine(B) and third group 3cc sterile water(C). Data collection tools were including of a demographic questionnaire, checklist of data and Partograph chart. Analysis of data done by SPSS (ver16) and Anova (tukey) and chi-square test.Results:Means of first stage of labor in Hyoscine group was 88.95±51.07 min, Hyoscine-Promethazine 100.05±65.88 min and control group 170.37±106.87 min. there is significant correlation between A,C and B, C groups (p<0.001). second stage means in group A was 46.37±44.60, group B 32.25±17.74 and control group 55.05±44.44 and significant relationship was between B,C groups(p=0.03) . In third stage no significant difference observed between groups (p=0.105).Conclusion:Sometimes and in some urgency cases, for decreasing duration of labor, we can use Hyoscine and Hyoscine-Promethazine.
150: USING EVIDENCE-BASED EDUCATION: A NECESSARY APPROACH IN THE PREVENTION OF EMERGING DISEASES CRIMEAN CONGO
Authors: atri Shirin Barzanjeh , Ranjbar Fatemeh , Sahebihag Mohammad hasan , Jafarabadi Mohammad Asgari , Vahedi Pedram , Balafar Molood , Keyhaniazar Elham 
Published: May 2024

Background and aims:Evidence-based education, integrating professional knowledge of current best evidence in making decisions about how to deliver the training. Using traditional methods of teaching can bring learning to deviate so the use of modern methods and scientific evidence crucial role in the decision-making training. The first level is placed on prevention education and Special education for at-risk groups on ways to control and prevent emerging diseases Crimean-Congo With 30 percent lethality is needed.Methods:The review of the literature between 2000 and 2016, with a focus on evidence-based education, traditional education, emerging diseases, prevention and Crimean-Congo in databases scholar Google, PubMed, Cochrane, Sid and Magiran results of applying slightly different methods training in the prevention of emerging diseases Crimean-Congo there.Results:The findings, few studies in educating in relation to Crimean – Congo show. The results of the study Sargolzaee (1392) as “the Crimean-Congo hemorrhagic fever surveillance system and general practitioners city of Zahedan, showed that doctors who spend history retraining program. The Congolese disease is more likely than other medical information. But the result of the use of evidence-based teaching methods in the prevention of emerging diseases Crimean-Congo, was not found.Conclusion:The literature review shows that education as an important way to prevent the disease, Crimean-Congo is emerging. The Aforementioned points show, identify and adopt appropriate measures, including evidence-based education in the prevention of disease, Crimean-Congo strongly felt.
180: IDENTIFYING ELECTRONIC HEALTH LITERACY LEVEL IN ADULT PATIENTS: AN IRANIAN EXPERIENCE
Authors: Valizadeh-Haghi Saeedeh , Seifi Leili 
Published: May 2024

Background and aims:Many people use the internet for healthcare information worldwide. But collecting information through the internet is different from other media and there is a gap between the electronic health resources available and consumers' skills for using them. Thus by growing Internet and its impact, computer and Internet literacy are becoming important skills for users. Therefore, E-Health literacy should be measured to get a comprehensive overview of people's skills to obtain and use health information. The aim of our study was to identify the level of electronic health literacy in adult patients which refer to dental clinics. This is especially important for patients with dental health care needs who requires to make decisions about various dental treatment plans. Yet, no information is available about this group.Methods:This was a descriptive-analytical cross sectional study. The method used was Convenience sampling and the population of study were 267 patients referred to the Sepehr dental clinic from May to June. The E-Health Literacy Scale (E-HEALS) was used to measure E-Health literacy. Descriptive analyses were conducted to address the study objectives.Results:The study revealed that most of the patients are low electronic health literate and it is needed to make improvement of patients' skills in internet resources use. Female patients use internet for health reasons more than male patients. Furthermore, the female patients are more literate than male patients.Conclusion:Exploring a patient's HL levels may provide a better understanding of the patient's potential barriers to self-management of dental diseases and health-promoting behaviours.
7: A SYSTEMATIC REVIEW ON VITAMIN D AND ANGIOGENESIS
Authors: Aliashrafi Soodabeh , Ebrahimi-Mameghani Mehrangiz 
Published: May 2024

Background and aims:Angiogenesis is the process of new blood vessel sprouting from the existing vasculature. It is physiologically present during wound healing, development of placenta, tissue growth and adipogenesis as well as playing role in pathological processes such as tumor growth, metastasis, obesity and non-alcoholic fatty liver disease (NAFLD). Angiogenesis therapy is as a Strategy for treatment of some diseases. The angiogenic process is regulated by numerous factors e.g. dietary factors. In this paper, we reviewed available documents and research relevant to vitamin D and angiogenesis.Methods:A systematic review of recent literature was conducted using the PRISMA guidelines. The sources of the data were PubMed, Google Scholar, Cochrane, Web of Science and Scopus. Key search terms were “Angiogenesis”, “Angiogenesis factor”, “vitamin D”, “1,25 (OH)2D3” and “Calciteriol”. Articles included in the review were original research articles in peer-reviewed journals which thoroughly examined and compared on the basis of study design, outcomes, and results.Results:The effect of vitamin D on angiogenesis was first reported in 1990. Evidence from current studies supports anti-angiogenesis and pro-angiogenesis effects of the 1, 25 (OH)2D3in several invivoandin vitrostudies. Results from recent studies implies that different effects of 1, 25 (OH)2D3on angiogenesis depends on the cellular types, cellular condition and type of chemokines released from the tissue. In cells with excessive angiogenesis, vitamin D addition results in decreased angiogenesis through reducing the activation, proliferation, migration, germination of endothelial cells whereas in the absence of vascular injury, vitamin D increases hypoxia-inducible factor 1-α (HIF1-α) and promoted Stromal Cell–Derived Factor 1 (SDF1) expression subsequently mediated vascular repair.Conclusion:Current literature suggests that Vitamin D has anti-angiogenic and pro- angiogenic effects. There is currently insufficient evidence about main and direct effect of vitamin D on angiogenesis. Further studies are needed to investigate the dominant role and different doses of vitamin D on Angiogenesis.
73: HOSPITAL EMERGENCY RESPONSE AGAINST DISASTERS: EVIDENCE FROM HOSPITALS IN IRAN
Authors: Janati Ali , Sadeghi-bazargani Homayoun , Hasanpoor Edris , Sokhanvar Mobin , HaghGoshyie Elaheh 
Published: May 2024

Background and aims:Hospitals play a critical role in providing communities with essential medical care during all types of disaster. Hospital emergency management is a continuing process requiring the monolithic integration of planning and response attempts with local and national schemes. The aim of the current study was to assess emergency response of hospitals against disasters in Tabriz.Methods:A cross-sectional study was conducted in Tabriz city, during 2016 in Iran. The study population included all hospitals in Tabriz city. 18 hospitals were assessed. Hospital emergency response checklist was used to collect data. Tool components including: Command and control, Communication, Safety and security, Triage, Surge capacity, Continuity of essential services, Human resources, Logistics and supply management and Post-disaster recovery. Data entry and analysis was done using SPSS-20.Results:The results showed that emergency response of hospitals were 54.26 percent in Tabriz. The lowest response rates were related to Shafaa hospital (18.89%) and highest response rates was related to Razi hospital (91.67%). Components of hospital emergency response were assessed between 48.07% (Surge capacity) to 58.95% (Communication).Conclusion:Based on WHO checklist, the only emergency response of hospitals were 54.26 percent in Tabriz. So, Hospital emergency responses against disasters have to be improved and should be 100 percent. It is essential to design a comprehensive framework for hospital emergency response.
82: INVESTIGATION OF METHODS OF ACCESS TO INFORMATION BY TONKABON RURAL WOMEN AND ITS IMPACT ON THEIR HEALTH
Authors: Mohasel Zahra Afsarion , Ghiasi Mitra , Zarei Hajar 
Published: May 2024

Background and aims:The current study is aimed at investigating the access of Tonekabon City's rural women to information and its impact on their health.Methods:The methodology used in this research is survey- analytical. The study population contains 42,283 rural women, residing in Tonekabon City in Mazandaran Province. Using the systematic random sampling method and the sampling formula of Kockran, the community sample numbered 297. The research tool was a questionnaire, made by the researcher. To analyze the data, the descriptive statistics (frequency table) and the interpretive statistics) mann whithney U and spearman Test) was applied.Results:The findings of this research indicated that watching TV was the main source of accessing the necessary health and medical information by rural women, while referring to a general practitioner came second in this regard. The main kind of medical information required by these women is related to gynecological and skin diseases. The role of internet resources and web pages in accessing medical and health information is also transparent. At the same time, a paucity of sufficient libraries and training classes along with inadequate information provided to women by health clinics in the rural areas have been among the main obstacles in the way of receiving health and medical information.Having put the hypothesis to test, it was shown that there was no meaningful difference between healthy people and patients in making use of the information recourses, with both groups favoring the resources on an equal basis. Testing the second hypothesis indicated a direct link between the education level and application of information resources.Conclusion:The survey findings show that not only ill people seek to gain medical and health information, but healthy people are also after receiving such necessary information. This is while those with a higher level of education pursue such information on a more frequent basis.
Do biological disease-modifying antirheumatic drugs reduce the spinal fracture risk related to ankylosing spondylitis? A longitudinal multiregistry matched cohort study
Authors: Robinson Yohan , Olerud Claes , Willander Johan 
Published: May 2024

ObjectivesAnkylosing spondylitis (AS) is associated with an increased spinal fracture risk due to the loss of elasticity in spinal motion segments. With the introduction of biological disease-modifying antirheumatic drug (bDMARD) treatment for AS, the individual course of the disease has been ameliorated. This study aims to examine the association of bDMARD treatment and risk of spinal fracture.DesignLongitudinal population-based multiregistry observational matched cohort study.SettingSwedish Patient Registry 1987–2014 and Swedish Prescribed Drugs Registry 2005–2014.ParticipantsIncluded were patients ≥18 years of age receiving treatment at a healthcare facility for the primary diagnosis of AS. About 1352 patients received more than one prescription of bDMARD from 2005 to 2014. An untreated control group was created by propensity score matching for age, sex, comorbidity, antirheumatic prescriptions and years with AS (n=1352).Main outcome measuresSpinal fracture-free survival.ResultsNo bDMARD treatment-related effect on spinal fracture-free survival was observed in the matched cohorts. Male gender (HR=2.54, 95% CI 1.48 to 4.36) and Charlson Comorbidity Index score (HR=3.02, 95% CI 1.59 to 5.75) contributed significantly to spinal fracture risk.ConclusionbDMARD had no medium-term effect on the spinal fracture-free survival in patients with AS.Trial registration numberNCT02840695; Post-results.
Study protocol for a randomised controlled trial of Allen Carr’s Easyway programme versus Lambeth and Southwark NHS for smoking cessation
Authors: Wood Kerry V , Albery Ian P , Moss Antony C , White Sarah , Frings Daniel 
Published: May 2024

IntroductionSmoking is a major cause of ill health and is associated with several diseases including cancer, coronary heart disease and stroke. Many psychological and pharmacological smoking cessation treatments are available and although they are undoubtedly the most cost-effective health interventions available, many people still fail to maintain cessation in the longer term. Recently, National Institute for Health and Care Excellence called for comparative studies to determine the short-term and long-term effectiveness of Allen Carr’s Easyway (ACE) method of stopping smoking. This study will compare the efficacy of the ACE programme and a 1–1 counselling service available via the National Health Service.Methods and analysisA two-arm, parallel-group, blinded, randomised controlled trial will be conducted with people who smoke tobacco cigarettes, are aged ≥18 years and are motivated to quit. Exclusion criteria comprise self-reported mental health condition, pregnancy or respiratory disease such as chronic obstructive pulmonary disease or emphysema. The primary treatment outcome is smoking cessation 26 weeks after treatment. Participants will be analysed on an intention to treat basis at the point of randomisation. Before being randomised, the research team will not inform participants which two treatments are being compared. Once randomised researchers will be blinded to participant condition, and participants will be blinded to the condition they are not assigned to. Logistic regression will be used to estimate the effectiveness of the treatment condition on smoking cessation at 26 weeks. The following covariates will be included: baseline quit efficacy (at inclusion), age (at inclusion), gender and baseline nicotine dependency.Ethics and disseminationApproval was granted by London–Fulham Research Ethics Committee (ref: 16/LO/1657). The study’s findings will be published in peer-reviewed journals and disseminated at national and international conferences.Trial registration numberClinicalTrials.gov identifier number:NCT02855255. ISRCTN registration number:ISRCTN23584477; Pre-results.
Protocol: a cluster randomised control trial study exploring stigmatisation and recovery-based perspectives regarding mental illness and substance use problems among primary healthcare providers across Toronto, Ontario
Authors: Khenti Akwatu , Mann Robert , Sapag Jaime C , Bobbili Sireesha J , Lentinello Emily K , Maas Mark van der , Agic Branka , Hamilton Hayley , Stuart Heather , Patten Scott , Sanches Marcos , Corrigan Patrick 
Published: May 2024

IntroductionPrimary care settings are often the first and only point of contact for persons with mental health and/or substance use problems. However, staff experience and training in this area are often limited. These factors as well as a multitude of other components such as structural and systemic stigma experienced by staff can lead to clients being stigmatised, leading to poorer outcomes. By developing a comprehensive intervention for primary care staff working at community health centres (CHCs) aimed at reducing stigma towards people with mental health and substance use problems (MHSUP), we sought to test an innovative and contact-based intervention consisting of staff training, raising awareness, a recovery-focused art programme and an analysis of internal policies and procedures. All of these components can inform and support staff so they can provide better care for people who are experiencing MHSUP. CHC staff members and clients will be included in this project as active participants.Methods and analysisThis mixed-methods project will consist of repeated surveys of staff and clients, as well as in-depth, semistructured interviews with a sample of clients and staff. A cluster randomised control trial design will test the effectiveness of an antistigma intervention for CHCs in Toronto, Canada. Six CHCs—three receiving the intervention and three controls—will be included in the study. Using a variety of measures, including the Opening Minds Scale for Health Care Providers (OMS-HC), Mental Illness: Clinicians Attitudes (MICA) Scale, Modified Bogardus Social Distance Scale, Perceived Devaluation-Discrimination Scale, Discrimination Experience subscale of the Internalized Stigma of Mental Illness (ISMI) Scale and the Recovery Assessment Scale (RAS), we hope to gain a thorough understanding of staff members’ attitudes and beliefs and clients’ perceptions of staff beliefs and behaviours. In-depth interviews will reveal important themes related to clients’ experiences of stigma both within and outside the healthcare setting.Ethics and disseminationIf demonstrated to be successful, this intervention can be used as a model for future initiatives aimed at reducing MHSUP-related stigma among healthcare providers in an organisational context. Adapting this work in other settings is a key strategic goal of this project. The project will also advance knowledge about stigma reduction and the experience of encountering stigma within a healthcare setting.Trial registrationNCT03043417; Post-results.
Transforaminal lumbar interbody fusion with cortical bone trajectory screws versus traditional pedicle screws fixation: a study protocol of randomised controlled trial
Authors: Feng Zhenhua , Li Xiaobin , Tang Qian , Wang Chenggui , Zheng Wenhao , Zhang Hui , Wu Ai-Min , Tian Naifeng , Wu Yaosen , Ni Wenfei 
Published: May 2024

IntroductionTransforaminal lumbar interbody fusion (TLIF) has been widely used in the treatment of lumbar degenerative disc disorders and shows favourable clinical results. Recently, cortical bone trajectory (CBT) has become a new trajectory for screw insertion in the lumbar spine. Several biomechanical studies have demonstrated that the CBT technique achieves screw purchase and strength greater than the traditional method. Currently, the available data on the clinical effectiveness of the two performed surgeries, TLIF with CBT screws (CBT-TLIF) and TLIF with traditional pedicle screws (PS-TLIF), are insufficient. This is the first randomised study to compare CBT-TLIF against traditional PS fixation and will provide recommendations for treating patients with lumbar degenerative disc disorders.Methods and analysisA blinded randomised controlled trial (blinding for the patient and statistician, rather than for the clinician and researcher) will be conducted. A total of 254 participants with lumbar disc degenerative disease who are candidates for TLIF surgery will be randomly allocated to either the CBT-TLIF group or the PS-TLIF group at a ratio of 1:1. The primary clinical outcome measures are the incidence of adjacent cranial facet joint violation, fusion rate and the screw loosening rate. Secondary clinical outcome measures are Visual Analogue Scale (VAS) of back pain, VAS of leg pain, Oswestry Disability Index, operative time, intraoperative blood loss and complications. These parameters will be evaluated on day 3, and then at 1, 3, 6, 12 and 24 months postoperatively.Ethics and disseminationThis study has been reviewed and approved by the Institutional Review Board of the Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University (batch: 2017–03). The results will be presented in peer-reviewed journals and an international spine-related meeting after completion of the study.Trial registration numberNCT03105167; Pre-results.