bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of Implant Design on Marginal Bone Changes Around Early Loaded, Chemically Modified, Sandblasted Acid‐Etched–Surfaced Implants: A Histologic Analysis in Dogs
Authors: Valderrama Pilar , Bornstein Michael M. , Jones Archie A. , Wilson Thomas G. , Higginbottom Frank L. , Cochran David L. 
Published: December 2010

Background:A minimal marginal bone loss around implants during early healing has been considered acceptable. However, the preservation of the marginal bone is related to soft tissue stability and esthetics. Implant designs and surfaces were evaluated to determine their impact on the behavior of the crestal bone. The purpose of this study is to evaluate histologic marginal bone level changes around early loaded, chemically modified, sandblasted acid‐etched–surfaced implants with a machined collar (MC) or no MC (NMC).Methods:Three months after a tooth extraction, 72 sandblasted acid‐etched chemically modified implants were placed in six dogs. Thirty‐six implants had NMC, and 36 implants had a 2.8‐mm MC. All implants were loaded 21 days after placement. For histologic analyses, specimens were obtained at 3 and 12 months. Assessments of the percentage of the total bone‐to‐implant contact and linear measurements of the distance from the shoulder of the implant to the first bone‐to‐implant contact (fBIC) were performed. Based on fBIC measurements, estimates of bone loss were obtained for each implant. A mixed‐model analysis of variance was used to assess the effects of implant type and sacrifice time.Results:All implants achieved osseointegration. The mean bone gain observed around NMC early loaded implants (at 3 months: 0.13 ± 0.37 mm; at 12 months: 0.13 ± 0.44 mm) was significantly different from the mean bone loss for MC early loaded implants (at 3 months: −0.32 ± 0.70 mm; at 12 months: −0.79 ± 0.35 mm) at 3 months (P= 0.003) and 12 months (P<0.001). No infrabony component was present at the marginal fBIC around NMC implants in most cases. There were no statistically significant differences among the means of total bone contact for implant types.Conclusions:Chemically modified, sandblasted acid‐etched–surfaced implants with NMC presented crestal bone gain after 3 and 12 months under loading conditions in the canine mandible. The implant design and surface were determinants in the marginal bone level preservation.
Effects of Cigarette Smoke Condensate and Nicotine on Human Gingival Fibroblast‐Mediated Collagen Degradation
Authors: Zhang Weiping , Fang Meixian , Song Fengyu , Windsor L. Jack 
Published: December 2010

Background: Members of the matrix metalloproteinase (MMP) family have been shown to be involved in periodontal disease. Risk factors for periodontal disease include tobacco smoking. Cigarette smoke condensate (CSC) is comprised of thousands of chemicals. Nicotine is one of the active components in tobacco. This study compares the effects of CSC and nicotine at the level in CSC on the collagen‐degrading ability of human gingival fibroblasts (HGFs) and the expression of selected MMPs and tissue inhibitors of metalloproteinases (TIMPs).Methods: HGFs were seeded in six‐well collagen‐coated plates, exposed to 100 μg/mL (2.4 μg/mL nicotine) of CSC or 2.4 μg/mL nicotine for 3 days, and then collagen degradation was analyzed. After 3 days exposure to CSC or nicotine, the conditioned media from HGFs was collected and the membrane proteins were extracted for gelatin zymography and Western blot analyses. The mRNA levels of MMP‐2, MMP‐14, and TIMP‐2 were measured by reverse transcription–polymerase chain reaction.Results: The CSC increased collagen degradation, and increased the levels of TIMP‐2, MMP‐14, and the active MMP‐2 in the membrane extracts, and their mRNA levels. CSC also increased the level of active MMP‐2 in the conditioned media. Nicotine at the level in CSC (2.4 μg/mL) had little influence on collagen degradation, as well as on the protein and mRNA levels of MMP‐2, MMP‐14, and TIMP‐2.Conclusions: CSC may increase HGF‐mediated collagen degradation by affecting membrane‐associated MMPs and TIMPs.
Petites marques du corps
Authors: Aisenstein Marilia 
Published: December 2010

Résumé Au travers d’un roman où, à propos d’une moustache, un homme fait une désorganisation psychique le menant au délire et à la psychose, puis de trois consultations avec une jeune femme qui à la suite d’une opération esthétique présente des manifestations aiguës de l’hystérie avec état crépusculaire, l’auteur s’interroge sur le statut « tabou » de certaines « petites marques du corps ». Elles concentreraient une accumulation de libido narcissique.
Tatouages et marques d'attention
Authors: Pailler Jean-Jacques 
Published: December 2010

Résumé Un chemin mène d’un sauteur à skis, d’alpinistes, filmés par W. Herzog, à un taggeur et finalement au tatouage. Celui-ci permet par la fonction d’attention de faire parvenir au moi de petites quantités d’excitations qui s’ajoutent à la libido sexuelle provenant de la coexcitation et du rapport à l’objet tatoueur afin de lutter contre un affaissement du moi. Comme une transfusion traitant l’hémorragie narcissique.
A TCR Targeting the HLA-A*0201–Restricted Epitope of MAGE-A3 Recognizes Multiple Epitopes of the MAGE-A Antigen Superfamily in Several Types of Cancer
Authors: Chinnasamy Nachimuthu , Wargo Jennifer A. , Yu Zhiya , Rao Mahadev , Frankel Timothy L. , Riley John P. , Hong Jenny J. , Parkhurst Maria R. , Feldman Steven A. , Schrump David S. , Restifo Nicholas P. , Robbins Paul F. , Rosenberg Steven A. , Morgan Richard A. 
Published: December 2010

Abstract
Adoptive immunotherapy using TCR-engineered PBLs against melanocyte differentiation Ags mediates objective tumor regression but is associated with on-target toxicity. To avoid toxicity to normal tissues, we targeted cancer testis Ag (CTA) MAGE-A3, which is widely expressed in a range of epithelial malignancies but is not expressed in most normal tissues. To generate high-avidity TCRs against MAGE-A3, we employed a transgenic mouse model that expresses the human HLA-A*0201 molecule. Mice were immunized with two HLA-A*0201–restricted peptides of MAGE-A3: 112–120 (KVAELVHFL) or MAGE-A3: 271–279 (FLWGPRALV), and T cell clones were generated. MAGE-A3–specific TCR α- and β-chains were isolated and cloned into a retroviral vector. Expression of both TCRs in human PBLs demonstrated Ag-specific reactivity against a range of melanoma and nonmelanoma tumor cells. The TCR against MAGE-A3: 112–120 was selected for further development based on superior reactivity against tumor target cells. Interestingly, peptide epitopes from MAGE-A3 and MAGE-A12 (and to a lesser extent, peptides from MAGE-A2 and MAGE-A6) were recognized by PBLs engineered to express this TCR. To further improve TCR function, single amino acid variants of the CDR3 α-chain were generated. Substitution of alanine to threonine at position 118 of the α-chain in the CDR3 region of the TCR improved its functional avidity in CD4 and CD8 cells. On the basis of these results, a clinical trial is planned in which patients bearing a variety of tumor histologies will receive autologous PBLs that have been transduced with this optimized anti–MAGE-A3 TCR.
Dicer Insufficiency and MicroRNA-155 Overexpression in Lupus Regulatory T Cells: An Apparent Paradox in the Setting of an Inflammatory Milieu
Authors: Divekar Anagha A. , Dubey Shweta , Gangalum Pallavi R. , Singh Ram Raj 
Published: December 2010

Abstract
Systemic lupus erythematosus is a chronic autoimmune disease characterized by loss of tolerance to self-Ags and activation of autoreactive T cells. Regulatory T (Treg) cells play a critical role in controlling the activation of autoreactive T cells. In this study, we investigated mechanisms of potential Treg cell defects in systemic lupus erythematosus using MRL-Faslpr/lpr (MRL/lpr) and MRL-Fas+/+ mouse models. We found a significant increase in CD4+CD25+Foxp3+ Treg cells, albeit with an altered phenotype (CD62L−CD69+) and with a reduced suppressive capacity, in the lymphoid organs of MRL strains compared with non-autoimmune C3H/HeOuj mice. A search for mechanisms underlying the altered Treg cell phenotype in MRL/lpr mice led us to find a profound reduction in Dicer expression and an altered microRNA (miRNA, miR) profile in MRL/lpr Treg cells. Despite having a reduced level of Dicer, MRL/lpr Treg cells exhibited a significant overexpression of several miRNAs, including let-7a, let-7f, miR-16, miR-23a, miR-23b, miR-27a, and miR-155. Using computational approaches, we identified one of the upregulated miRNAs, miR-155, that can target CD62L and may thus confer the altered Treg cell phenotype in MRL/lpr mice. In fact, the induced overexpression of miR-155 in otherwise normal (C3H/HeOuj) Treg cells reduced their CD62L expression, which mimics the altered Treg cell phenotype in MRL/lpr mice. These data suggest a role of Dicer and miR-155 in regulating Treg cell phenotype. Furthermore, simultaneous appearance of Dicer insufficiency and miR-155 overexpression in diseased mice suggests a Dicer-independent alternative mechanism of miRNA regulation under inflammatory conditions.
TLR-2–Activated B Cells Suppress Helicobacter-Induced Preneoplastic Gastric Immunopathology by Inducing T Regulatory-1 Cells
Authors: Sayi Ayca , Kohler Esther , Toller Isabella M. , Flavell Richard A. , Müller Werner , Roers Axel , Müller Anne 
Published: December 2010

Abstract
B cells regulate autoimmune pathologies and chronic inflammatory conditions such as autoimmune encephalomyelitis and inflammatory bowel disease. The potential counterregulatory role of B cells in balancing pathogen-specific immune responses and the associated immunopathology is less well understood owing to the lack of appropriate persistent infection models. In this paper, we show that B cells have the ability to negatively regulate adaptive immune responses to bacterial pathogens. Using mouse models of infection with Helicobacter felis, a close relative of the human gastrointestinal pathogen H. pylori, we found that B cells activated by Helicobacter TLR-2 ligands induce IL-10–producing CD4+CD25+ T regulatory-1 (Tr-1)–like cells in vitro and in vivo. Tr-1 conversion depends on TCR signaling and a direct T-/B-interaction through CD40/CD40L and CD80/CD28. B cell-induced Tr-1 cells acquire suppressive activity in vitro and suppress excessive gastric Helicobacter-associated immunopathology in vivo. Adoptive cotransfer of MyD88-proficient B cells and Tr-1 cells restores a normal gastric mucosal architecture in MyD88−/− and IL-10−/− mice in a manner that depends on T cellular, but not B cellular, IL-10 production. Our findings describe a novel mechanism of B cell-dependent Tr-1 cell generation and function in a clinically relevant disease model. In conclusion, we demonstrate that the B cell/Tr-1 cell axis is essential for balancing the control of Helicobacter infection with the prevention of excessive Th1-driven gastric immunopathology, promoting gastric mucosal homeostasis on the one hand and facilitating Helicobacter persistence on the other.
The C5a Receptor Impairs IL-12–Dependent Clearance of Porphyromonas gingivalis and Is Required for Induction of Periodontal Bone Loss
Authors: Liang Shuang , Krauss Jennifer L. , Domon Hisanori , McIntosh Megan L. , Hosur Kavita B. , Qu Hongchang , Li Fenge , Tzekou Apostolia , Lambris John D. , Hajishengallis George 
Published: December 2010

Abstract
The C5a anaphylatoxin receptor (C5aR; CD88) is activated as part of the complement cascade and exerts important inflammatory, antimicrobial, and regulatory functions, at least in part, via crosstalk with TLRs. However, the periodontal pathogen Porphyromonas gingivalis can control C5aR activation by generating C5a through its own C5 convertase-like enzymatic activity. In this paper, we show that P. gingivalis uses this mechanism to proactively and selectively inhibit TLR2-induced IL-12p70, whereas the same pathogen-instigated C5aR-TLR2 crosstalk upregulates other inflammatory and bone-resorptive cytokines (IL-1β, IL-6, and TNF-α). In vivo, the ability of P. gingivalis to manipulate TLR2 activation via the C5a-C5aR axis allowed it to escape IL-12p70–dependent immune clearance and to cause inflammatory bone loss in a murine model of experimental periodontitis. In the latter regard, C5aR-deficient or TLR2-deficient mice were both resistant to periodontal bone loss, in stark contrast with wild-type control mice, which is consistent with the interdependent interactions of C5aR and TLR2 in P. gingivalis immune evasion and induction of bone-resorptive cytokines. In conclusion, P. gingivalis targets C5aR to promote its adaptive fitness and cause periodontal disease. Given the current availability of safe and effective C5aR antagonists, pharmacological blockade of C5aR could act therapeutically in human periodontitis and reduce associated systemic risks.
Infrared Spectral Emissivity Dynamics of Surfaces Under Water Condensation
Authors: Lavielle Nicolas , Othman Ahmed M. , Hervé Armande , Hamaoui Georges , Fei Jipeng , Tan Jun Yan , Marty Frédéric , Li Hong , Mongruel Anne , Beysens Daniel , Nefzaoui Elyes , Bourouina Tarik 
Published: May 2024

AbstractWater condensation on a surface strongly affects its effective emissivity, especially in the atmospheric window, a wavelength range essential for outdoor applications related to energetically passive cooling and heating. The evolution of emissivity of a silicon surface during dropwise and filmwise water deposition is studied. The evolution of the spectral radiative properties shows that the increase in effective emissivity due to the growth of a droplet pattern is steeper than for a growing water film of equivalent thickness. The change of surface emissivity takes place in the first moments of condensation where droplets as small as 10 µm drastically impact the reflectance of the pristine surface. The upper limit of effective emissivity is reached for a droplet radius or film thickness of 50 µm. During dropwise condensation, effective emissivity is weighted by the drop surface coverage and then remains within an asymptotic maximum value of 0.8, while in case of filmwise condensation, it is shown to reach 0.9 corresponding to water emissivity. Micrometer‐scale spatially‐resolved infrared spectral images enable to correlate the spatial variation of spectral properties to the droplet size and localization. Such findings are of interest to the implementation of moisture‐controlled emissivity tuning and radiative sky‐coolers for dew harvesting.
Hot Exciton Carbon Dots‐Based Deep Blue Electroluminescent Light‐Emitting Diodes Exceeding 7% External Quantum Efficiency
Authors: Wang Boyang , Wang Hongwei , Zhang Baowei , Hu Yongsheng , Lu Siyu 
Published: May 2024

AbstractCarbon dots (CDs) have emerged as an exceptional material for the emission layer in the new generation of electroluminescent light‐emitting diodes (ELEDs) owing to their low cost, high stability, and high luminous efficiency. Although blue CDs‐based ELEDs have a wide bandgap and a low exciton utilization efficiency (EUE), it is still challenging to increase their external quantum efficiency (EQE). Although thermally activated delayed fluorescence and triplet‐triplet annihilation may improve EUE, the design of blue ELEDs is complicated by the significant charge transfer characteristics introduced by the low energy spitting of T1 and S1. This research effectively produced blue‐emitting CDs using a heated exciton process by carefully selecting precursors to overcome the aforementioned challenges. Deep blue and blue ELEDs based on CDs are developed by manipulating the electron‐hole mobility and the energy level structure of the device. The EQEs of these ELEDs exceeded those of previously reported CDs‐based blue ELEDs by over 7%. This study presents design concepts for new CDs and introduces a novel approach to develop cost‐effective, environmentally friendly, and highly efficient metal‐free blue ELEDs.
A Database of Electrochemical Stability Windows Containing over 1500 Solid‐State Inorganic Compounds
Authors: Wang Xianyue , He Bing , Liu Bo , Avdeev Maxim , Shi Siqi 
Published: May 2024

AbstractElectrochemical stability window (ESW) of an inorganic compound (solid‐state electrolyte (SSE) or coating) is an indispensable parameter to evaluate the interface compatibility between the electrode and electrolyte in ion batteries. The discovery of novel coatings and SSEs, driven by extensive ESW data, is expected to accelerate the design of high‐performance batteries. However, only a very small fraction of the ESW of inorganic compounds has been experimentally measured at present, which limits technological progress. Benefiting from the high‐accuracy ESW prediction with dynamically determined direct or indirect decomposition pathway proposed in the previous work, both the oxidation and reduction potentials align to the experimental data reasonably. Here, a database containing phase diagrams and electrochemical stability information is established for more than 1500 solid‐state inorganic compounds with Li+, Na+, K+, Mg2+, Ca2+, and Al3+ as the migrating ions, and this number is still growing. The database is reproducible and provides a unified picture of the structure–activity relationships associated with electrochemical stability of inorganic compounds. This study demonstrates the validity of the improved ESW prediction method and paves the way for accelerated screening of superior SSEs or coatings based on machine learning.
Single Dispersion of Fe(H2O)2‐Based Polyoxometalate on Polymeric Carbon Nitride for Biomimetic CH4 Photooxidation
Authors: Ren Jing , Wang Baifan , Yin Hua‐Qing , Zhang Peng , Wang Xin‐Hui , Quan Yangjian , Yao Shuang , Lu Tong‐Bu , Zhang Zhi‐Ming 
Published: May 2024

AbstractDirect methane conversion to value‐added oxygenates under mild conditions with in‐depth mechanism investigation has attracted wide interest. Inspired by methane monooxygenase, the K9Na2Fe(H2O)2{[γ‐SiW9O34Fe(H2O)]}2·25H2O polyoxometalate (Fe‐POM) with well‐defined Fe(H2O)2 sites is synthesized to clarify the key role of Fe species and their microenvironment toward CH4 photooxidation. The Fe‐POM can efficiently drive the conversion of CH4 to HCOOH with a yield of 1570.0 µmol gPOM−1 and 95.8% selectivity at ambient conditions, much superior to that of [Fe(H2O)SiW11O39]5− with Fe(H2O) active site, [Fe2SiW10O38(OH)]214− and [P8W48O184Fe16(OH)28(H2O)4]20− with multinuclear Fe−OH−Fe active sites. Single‐dispersion of Fe‐POM on polymeric carbon nitride (PCN) is facilely achieved to provide single‐cluster functionalized PCN with well‐defined Fe(H2O)2 site, the HCOOH yield can be improved to 5981.3 µmol gPOM−1. Systemic investigations demonstrate that the (WO)4−Fe(H2O)2 can supply Fe═O active center for C−H activation via forming (WO)4−Fea−Ot···CH4 intermediate, similar to that for CH4 oxidation in the monooxygenase. This work highlights a promising and facile strategy for single dispersion of ≈1–2 Å metal center with precise coordination microenvironment by uniformly anchoring nanoscale molecular clusters, which provides a well‐defined model for in‐depth mechanism research.
Highly Efficient Luminescent Solar Concentrators Based on BODIPY Derivatives
Authors: Arrigo Antonino , Gangemi Chiara Maria Antonietta , Barattucci Anna , Bonaccorsi Paola Maria , Greco Valentina , Giuffrida Alessandro , Genovese Salvatore , Campagna Sebastiano , Nastasi Francesco , Puntoriero Fausto 
Published: May 2024

AbstractThree new chromophores based on difluoroborondipyrromethene dyes (Bodipy‐1, Bodipy‐2, and Bodipy‐3) are used as precursors to prepare luminescent solar concentrators (LSC) based on poly‐acrylate, following a thermally activated polymerization involving lauryl methacrylate as monomer, ethyl glycol dimethacrylate as cross‐linking agent, and lauroyl peroxide as initiator. The new dyes exhibit typical BODIPY absorption and emission properties in dichloromethane fluid solution, assigned to the lower‐lying singlet π–π∗ level, which in the case of Bodipy‐2 and Bodipy‐3, both containing diamino‐substituted styryl subunits in their structure, has a strong charge transfer contribution. The LSCs obtained starting from each of the three Bodipys are interfaced to silicon photovoltaic (PV) cells, and the PV light‐to‐energy conversion efficiencies ηopt for the three systems are calculated. The results yield ηopt of 4.53% for LSC‐Bodipy‐1, 5.26% for LSC‐Bodipy‐2, and 8.23% for LSC‐Bodipy‐3. The optical efficiency for LSC‐Bodipy‐3 is a remarkable value among the LSC based on organic dyes.
Uniaxial‐Stress Driven Performance Enhancement of Multi‐Beam Spark Plasma Sintered BiSbTe/Epoxy Flexible Films
Authors: Ai Xiaoling , Ke Shaoqiu , Nie Xiaolei , Chen Tiantian , Liang Dong , Fu Kai , Zhu Wanting , Wei Ping , Zhao Wenyu , Zhang Qingjie 
Published: May 2024

AbstractThe multi‐beam discharge plasma sintering (MB‐SPS) method is successfully applied to the preparation of Bi2Te3‐based thermoelectric (TE) films with insulating substrates. Herein, the impact of uniaxial stress on the microstructure evolution and TE performance are explored systematically. The results indicate that the increase of uniaxial stress promotes the preferential growth of Bi0.5Sb1.5Te3 (BST) grains along the (000l) crystal plane, leading to the remarkable increase in carrier mobility. The maximum (000l) preferential orientation factor reaches 80% for the BST/epoxy (EP) film sintered under 25 MPa, which is 3.08 times higher than that of BST/EP film sintered at 10 MPa. While the highest power factor reaches 2.36 mW m−1 K−2 at 300 K for the BST/EP film sintered under 20 MPa, increased by 97% as compared with that of the film sintered under 10 MPa. This work once again confirms that the MB‐SPS technology is an effective approach to prepare high‐performance Bi2Te3‐based films with insulating substrates and demonstrates that the (000l) preferential orientation and TE performance of the films can be further enhanced by an appropriate uniaxial stress.
Highly Efficient Broadband Near‐Infrared Emission in Cr3+‐Activated Organic Hafnium Chlorine for Multi‐Optoelectronic Applications
Authors: Lai Jun'an , Wang Zixian , Wang Yijia , Cao Sijun , Wu Daofu , Zhou Yongqiang , An Kang , Du Juan , He Peng , Tang Xiaosheng 
Published: May 2024

AbstractCr3+ ions doped broadband emission near‐infrared (NIR) phosphors are pertinent to widespread emerging applications and get rapid developed. However, it remains a challenge to simultaneously achieve highly efficient and broadband near‐infrared emission in Cr3+ ions doped phosphors. Herein, the Cr3+ ions firstly doped into organic–inorganic hafnium chlorine TEA2HfCl6 (TEA = Tetraethylammonium, C8H20N), which show broadband emission at a range of 700–1300 nm, a full width at half maximum (FWHM) of 164 nm, and a high photoluminescence quantum yield (PLQY) of 60%. The organic–inorganic metal halides show huge advantages than traditional inorganic phosphors, like high luminescence efficiency, low temperature solution synthesis progress, and low cost, which provide an efficiency strategy for lighting industry. Based on these advantages, a high power NIR light emitting diode (LED) is fabricated by TEA2HfCl6:Cr3+ with a high‐power 530 nm chip, which is used in food analysis, night vision, and biomedical imaging as a demonstration. This work indicates the feasibility of organic–inorganic metal halides as host materials for developing Cr3+ ions emitting phosphor toward multi‐optoelectronic applications.