bluuebunny/crossref_metadata_2025_split huggingface dataset:
Unlocking Maximum Synergy: Screen‐Printing Fabrication of Heterostructured Microsupercapacitor Stacks
Authors: Chen Jiankang , Han Dong , Deng Jiahua , Li Binbin , Wang Tingyi , Cao Liuguan , Zhang Lili , Lai Linfei 
Published: May 2024

AbstractA cost‐effective and scalable approach for the fabrication of heterostructured microsupercapacitors (MSCs) employing screen‐printing followed by sequential electrochemical and microspray deposition techniques has been demonstrated. The microsupercapacitor electrode (MSC) that composed of stacked layers of mesoporous carbon, polyaniline (PANI), and MXene hold significant promise for wearable electronics. By adjusting the deposition and spray cycles, the MSC can be readily coated with PANI and MXene. The sequentially stacked two layers of MXene and PANI on the mesoporous carbon spheres (PMPM‐MSC) yielded a specific capacitance of 1003 mF cm−2 at 0.5 mA cm−2, surpassing the performance of PANI/mesoporous carbon electrode by 1.6 times (771 mF cm−2). After 10,000 cycles of charge and discharge, PMPM‐MSCs retained more than 86% of their initial capacitance. In‐situ Raman spectroscopy confirmed the synergistic effects between MXene and PANI within the heterostructured stacked PMPM‐MSC electrodes, including enhanced electronic conductivity and improved electrolyte ion dissociation, which aligned with the electrochemical measurement results, such as fast charge/discharge rates and reduced internal and mass transport resistance. This study demonstrates the potential of screen‐printed heterostructured MSC stacks with maximum electrochemical synergy for portable and wearable energy storage devices.
Stimulated recall, teacher beliefs, and teacher practices: Using structured reflective practice to examine teacher talk
Authors: Ahmed Aram Ali , Montecillo Leider Christine 
Published: May 2024

AbstractTeacher talk is one of the key instructional components in English language teaching classrooms. This study used reflective practice and stimulated recall to investigate teacher beliefs and practices about teacher talk. Data came from two participants who teach English as a second language (ESL) courses at a private university in the United States. Findings of the study illustrated a disconnect between teacher beliefs and practices regarding teacher talk, suggested that quality and quantity of teacher talk are intertwined constructs that cannot be understood in isolation of each other, and highlighted the role of silent time in teacher talk. Implications for how stimulated recall through reflective practice can be used as a teacher education tool are discussed.
Tracheomalacia in patients undergoing thyroid surgery—What is the true estimate: A systematic review and meta‐analysis
Authors: Ghaloo Shayan Khalid , Afzal Syed Shabbir , Abbas Syed Akbar , Ansari Shayan , De Mriganka , Iftikhar Haissan 
Published: May 2024

AbstractObjectivesTracheomalacia is defined as the weakening of the tracheal rings secondary to long‐standing compression or inherent structural weakness, leading to stridor and airway compromise. The common etiological factor of tracheomalacia includes compression of the tracheal framework due to a large multinodular goiter. There are various management techniques described in the literature to manage a patient with tracheomalacia including tracheostomy, tracheal stenting, and tracheopexy. However, the evidence of tracheomalacia in the literature is conflicting. Therefore, a systematic review was conducted to estimate the incidence of tracheomalacia after thyroidectomy.MethodsThe systematic review was conducted according to Preferred Reporting Items for Systematic Reviews and Meta‐Analyses (PRISMA) guidelines. A literature search was performed on PubMed, Web of Science, Cochrane library, and Elton B. Stephens Co. cumulative index to nursing and allied health literature plus to determine the incidence of tracheomalacia among patients undergoing thyroidectomy up till October 2021. The eligibility was assessed by two independent authors. A quality assessment of individual studies was performed using the National Institute of Health quality assessment tool. Outcomes were double data extracted and were analyzed using OpenMeta.ResultsThe online search retrieved 214 papers, out of which 17 studies were included that fulfilled the eligibility criteria. The number of patients included in the systematic review who underwent thyroidectomy was 1108. The mean age was 55.8 ± 7.7 years, ranging from 48 to 75 years. Tracheomalacia was reported in 146 patients (1.4%). Sternotomy was performed in 102 patients to approach the goiters with retrosternal extension. The most common intervention to manage tracheomalacia was tracheostomy or prolonged intubation.ConclusionsTracheomalacia is a rare complication. In cases where tracheomalacia is encountered, common methods of management include tracheostomy or prolonged endotracheal intubation. Prospective, long‐term studies are required to accurately assess its true incidence and associated factors.
Conclusion
Authors: Klingebiel Stephan , Hartmann Flora L. , Madani Elisa , Paintner Jonas , Rohe Rebekka A. , Trebs Lisa , Wolk Teodor 
Published: May 2024

AbstractFinally, we summarise overall learnings and provide a perspective beyond the initial research question of our project. We present insights based on our empirical engagement with the topic, but these insights have also sharpened our conceptual thinking. Our research questions have been answered in the previous chapters in detail. Here, we bring together overarching reflections in condensed form.
Xenotransplantation von Organen
Authors: Schmoeckel Michael , Längin Matthias , Reichart Bruno , Abicht Jan-Michael , Bender Martin , Denner Joachim , Marckmann Georg , Brenner Paolo , Wolf Eckhard , Hagl Christian 
Published: May 2024

ZusammenfassungDie Transplantation genetisch veränderter Schweineherzen und -nieren kann in den nächsten Jahren eine Lösung für den bestehenden Mangel an Organspendern darstellen. Fortschritte im Bereich des „Genetic Engineering“, aber auch verbesserte Organpräservationstechniken, eine Immunsuppression mit Kostimulationsblockade (Anti-CD40/CD40L-mAb) sowie eine verbesserte virologische Diagnostik, um eine Übertragung von pathogenen Schweineviren auf den Empfänger zu verhindern, haben hierzu beigetragen. Da Landrasse-Schweineorgane auch im Transplantatempfänger ihre Originalgröße erreichen, werden nun Schweinerassen verwendet, die entweder ein für den Menschen passendes Endgewicht erreichen (z. B. Auckland Island-Schweine) oder deren Wachstumshormonrezeptor genetisch inaktiviert wurde (z. B. in 10fach genetisch veränderten Schweinen der Fa. Revivicor/United Therapeutics, USA). Mit der ersten klinischen Pilotstudie an terminal Herzkranken wird in Deutschland in ca. 2 Jahren gerechnet.
Graphic abstract
FPDclustering: a comprehensive R package for probabilistic distance clustering based methods
Authors: Tortora Cristina , Palumbo Francesco 
Published: May 2024

Abstract
Data clustering has a long history and refers to a vast range of models and methods that exploit the ever-more-performing numerical optimization algorithms and are designed to find homogeneous groups of observations in data. In this framework, the probability distance clustering (PDC) family methods offer a numerically effective alternative to model-based clustering methods and a more flexible opportunity in the framework of geometric data clustering. Given n
J-dimensional data vectors arranged in a data matrix and the number K of clusters, PDC maximizes the joint density function that is defined as the sum of the products between the distance and the probability, both of which are measured for each data vector from each center. This article shows the capabilities of the PDC family, illustrating the package .
The integration of risk into management control systems: towards a deeper understanding across multiple levels of analysis
Authors: Hiebl Martin R. W. 
Published: May 2024

AbstractThe integration of risk into management control has recently received increased attention in the management accounting and control literature. Much of this research has focused on the organizational and individual actor level. However, some studies suggest that the integration of risk into the organizational control package may equally be influenced by forces operating at other levels of analysis– including the economic and political level and the organizational field level. In this guest editorial for the special issue on “Courageous Risk Governance: Enabling Resilience, Autonomy, and New Thinking,” I therefore discuss how our collective understanding of the integration of risk into management control could be enhanced by research at multiple levels of analysis. The papers included in this special issue show that when this integration is successfully managed, organizations can achieve valuable outcomes, such as increased resilience. For both practitioners and academics, future research on such integration therefore seems fruitful and necessary. This article provides ideas for particularly relevant questions about this integration and for theories that can guide such research.
Infinite time blow-up for the three dimensional energy critical heat equation in bounded domains
Authors: Ageno Giacomo , Pino Manuel del 
Published: May 2024

AbstractWe consider the Dirichlet problem for the energy-critical heat equation $$\begin{aligned} {\left\{ \begin{array}{ll} u_t=\Delta u+u^5 & \text {in} \quad \Omega \times \mathbb {R}^+,\\ u=0 & \text {on} \quad \partial \Omega \times \mathbb {R}^+,\\ u(x,0)=u_0(x) & \text {in} \quad \Omega , \end{array}\right. } \end{aligned}$$

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,
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)

=

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0

(
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)

in

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,

where $$\Omega $$
Ω
is a bounded smooth domain in $$\mathbb {R}^3$$

R

3

. Let $$H_\gamma (x,y)$$

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γ

(
x
,
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)

be the regular part of the Green function of $$-\Delta -\gamma $$

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in $$\Omega $$
Ω
, where $$\gamma \in (0,\lambda _1)$$

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,

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and $$\lambda _1$$

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1

is the first Dirichlet eigenvalue of $$-\Delta $$

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Δ

. Then, given a point $$q\in \Omega $$

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∈
Ω

such that $$3\gamma (q)<\lambda _1$$

3
γ

(
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)

<

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, where $$\begin{aligned} \gamma (q) :=\sup \{ \gamma>0: H_\gamma (q,q)>0 \}, \end{aligned}$$

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sup
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:

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>
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,

we prove the existence of a non-radial global positive and smooth solution u(x, t) which blows up in infinite time with spike in q. The solution has the asymptotic profile $$\begin{aligned} u(x,t)\sim 3^{\frac{1}{4}} \left( \frac{\mu (t)}{\mu (t)^2+\vert x-\xi (t)\vert ^2}\right) ^{\frac{1}{2}} \quad \text {as}\quad t \rightarrow \infty , \end{aligned}$$

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(
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as

t
→
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,

where $$\begin{aligned} -\ln (\mu (t))= 2\gamma (q) t(1+o(1)),\quad \xi (t)=q+O(\mu (t)) \quad \text {as}\quad t \rightarrow \infty . \end{aligned}$$

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.
circATAD2 mitigates CD8+ T cells antitumor immune surveillance in breast cancer via IGF2BP3/m6A/PD-L1 manner
Authors: Zhang Zhiling , Huo Wenjie , Li Jie 
Published: May 2024

AbstractImmune surveillance and chemotherapy sensitivity play critical functions in the tumorigenesis of breast cancer (BC). Emerging findings have indicated that circular RNA (circRNA) and N6-methyladenosine (m6A) both participate in the BC tumorigenesis. Here, present study aimed to investigate the roles of m6A-modified circATAD2 on BC and explore better understanding for BC precision therapeutic. Results reported that m6A-modifid circRNA (m6A-circRNA) microarray revealed the m6A-circRNA landscape in BC. M6A-modifid circATAD2 upregulated in BC samples and was closely correlated to poor prognosis. Functionally, circATAD2 promoted the immune evasion of BC cells and reduced the CD8+ T cells’ killing effect. Mechanistically, MeRIP-seq unveiled the m6A modification in the 3’-UTR of PD-L1 mRNA, which was bound by circATAD2 and recognized by m6A reader IGF2BP3 to enhance PD-L1 mRNA stability and expression. In summary, these findings revealed the circATAD2/m6A/IGF2BP3/PD-L1 axis in BC immune surveillance, suggesting the potential that circATAD2 as a potential target for PD-L1-mediated BC.
GGT5: a potential immunotherapy response inhibitor in gastric cancer by modulating GSH metabolism and sustaining memory CD8+ T cell infiltration
Authors: Zhao Wenjing , Liang Ziwei , Yao Yongshi , Ge Yang , An Guangyu , Duan Ling , Yao Jiannan 
Published: May 2024

Abstract
Purpose
The variable responses to immunotherapy observed in gastric cancer (GC) patients can be attributed to the intricate nature of the tumor microenvironment. Glutathione (GSH) metabolism significantly influences the initiation and progression of gastric cancer. Consequently, targeting GSH metabolism holds promise for improving the effectiveness of Immune checkpoints inhibitors (ICIs).

Methods
We investigated 16 genes related to GSH metabolism, sourced from the MSigDB database, using pan-cancer datasets from TCGA. The most representative prognosis-related gene was identified for further analysis. ScRNA-sequencing analysis was used to explore the tumor heterogeneity of GC, and the results were confirmed by Multiplex immunohistochemistry (mIHC).

Results
Through DEGs, LASSO, univariate and multivariate Cox regression analyses, and survival analysis, we identified GGT5 as the hub gene in GSH metabolism with the potential to promote GC. Combining CIBERSORT, ssGSEA, and scRNA analysis, we constructed the immune architecture of GC. The subpopulations of T cells were isolated, revealing a strong association between GGT5 and memory CD8+ T cells. Furthermore, specimens from 10 GC patients receiving immunotherapy were collected. mIHC was used to assess the expression levels of GGT5 and memory CD8+ T cell markers. Our results established a positive correlation between GGT5 expression, the enrichment of memory CD8+ T cells, and a suboptimal response to immunotherapy.

Conclusions
Our study identifies GGT5, a hub gene in GSH metabolism, as a potential therapeutic target for inhibiting the response to immunotherapy in GC patients. These findings offer new insights into strategies for optimizing immunotherapy of GC.
Signal enhancement ratio of multi-phase contrast-enhanced MRI: an imaging biomarker for survival in pancreatic adenocarcinoma
Authors: Xia Cong , Qu Jin-rong , Jiao Yi-ping , Lu Chun-qiang , Zhao Ben , Ge Rong-jun , Qiu Yue , Cao Bu-yue , Yu Qian , Xia Tian-yi , Meng Xiang-pan , Song Yang , Zhang Li-hua , Long Xue-ying , Ye Jing , Ding Zhi-min , Cai Wu , Ju Sheng-hong 
Published: May 2024

Abstract
Objectives
To evaluate signal enhancement ratio (SER) for tissue characterization and prognosis stratification in pancreatic adenocarcinoma (PDAC), with quantitative histopathological analysis (QHA) as the reference standard.

Methods
This retrospective study included 277 PDAC patients who underwent multi-phase contrast-enhanced (CE) MRI and whole-slide imaging (WSI) from three centers (2015–2021). SER is defined as (SIlt − SIpre)/(SIea − SIpre), where SIpre, SIea, and SIlt represent the signal intensity of the tumor in pre-contrast, early-, and late post-contrast images, respectively. Deep-learning algorithms were implemented to quantify the stroma, epithelium, and lumen of PDAC on WSIs. Correlation, regression, and Bland-Altman analyses were utilized to investigate the associations between SER and QHA. The prognostic significance of SER on overall survival (OS) was evaluated using Cox regression analysis and Kaplan–Meier curves.

Results
The internal dataset comprised 159 patients, which was further divided into training, validation, and internal test datasets (n = 60, 41, and 58, respectively). Sixty-five and 53 patients were included in two external test datasets. Excluding lumen, SER demonstrated significant correlations with stroma (r = 0.29–0.74, all p < 0.001) and epithelium (r = −0.23 to −0.71, all p < 0.001) across a wide post-injection time window (range, 25–300 s). Bland-Altman analysis revealed a small bias between SER and QHA for quantifying stroma/epithelium in individual training, validation (all within ± 2%), and three test datasets (all within ± 4%). Moreover, SER-predicted low stromal proportion was independently associated with worse OS (HR = 1.84 (1.17–2.91), p = 0.009) in training and validation datasets, which remained significant across three combined test datasets (HR = 1.73 (1.25–2.41), p = 0.001).

Conclusion
SER of multi-phase CE-MRI allows for tissue characterization and prognosis stratification in PDAC.

Clinical relevance statement
The signal enhancement ratio of multi-phase CE-MRI can serve as a novel imaging biomarker for characterizing tissue composition and holds the potential for improving patient stratification and therapy in PDAC.

Key Points

Imaging biomarkers are needed to better characterize tumor tissue in pancreatic adenocarcinoma.

Signal enhancement ratio (SER)-predicted stromal/epithelial proportion showed good agreement with histopathology measurements across three distinct centers.

Signal enhancement ratio (SER)-predicted stromal proportion was demonstrated to be an independent prognostic factor for OS in PDAC.

Graphical Abstract
Clinicopathologic features and genomic profiling of female axillary lymph node metastases from adenocarcinoma or poorly differentiated carcinoma of unknown primary
Authors: Tang Liansha , Zhu Yueting , Du Yang , Long Xiangyu , Long Yixiu , Tang Yuan , Liu Jiyan 
Published: May 2024

Abstract
Purpose
Axillary lymph node metastases from adenocarcinoma or poorly differentiated carcinoma of unknown primary (CUPAx) is a rare disease in women. This retrospective study intended to examine the clinicopathological features of CUPAx and compared CUPAx genetically with axillary lymph node metastases from breast cancer (BCAx), investigating differences in their biological behavior.

Methods
We conducted the clinical and prognostic analysis of 58 CUPAx patients in West China Hospital spanning from 2009 to 2021. Gemonic profiling of 12 CUPAx patients and 16 BCAx patients was conducted by the FoundationOne CDx (F1CDx) platform. Moreover, we also compared the gene mutation spectrum and relevant pathways between the two groups and both TCGA and COSMIC databases.

Results
The majority of the 58 CUPAx patients were HR-/HER2- subtype. Most patients received mastectomy combined radiotherapy (50 Gy/25f). CUPAx patients who received mastectomy instead of breast-conserving surgery had a more favorable overall prognosis. Radiotherapy in chest wall/breast and supraclavicular/infraclavicular fossa was the independent prognostic factor (HR = 0.05, 95%CI = 0.00–0.93, P = 0.04). In 28 sequencing samples (CUPAx, n = 12, BCAx, n = 16) and 401 TCGA-BRCA patients, IRS2 only mutated in CUPAx (33.33%) but amplified in BCAx (11.11%) and TCGA-BRCA (1.5%). Pathway analysis revealed that BCAx had more NOTCH pathway mutations than CUPAx. Enrichment analysis showed that CUPAx enriched more in mammary development and PML bodies than BCAx, but less in the positive regulation of kinase activity.

Conclusions
More active treatment methods, like chemotherapy, mastectomy and postoperative radiotherapy, could improve the prognosis of CUPAx. The differential mutation genes of CUPAx and BCAx might be associated with their respective biological behaviors like invasiveness and prognosis.
A study of the effect of half-day climatotherapy on changes in salivary cortisol levels
Authors: Kanayama Hitomi , Kusaka Yukinori , Inoue Hiroyuki , Hirai Takayoshi , Schuh Angela 
Published: May 2024

AbstractIn our previous study setting, climatotherapy programme consisted of six sessions – four in the mid-mountain area and two in a flat park. For all sessions, the subjects underwent climatotherapy in the morning under slightly cool conditions. During each session, the subjects’ blood pressure, pulse rate, skin temperature, blood lactate, salivary cortisol and mood profile were recorded, and meteorological data were collected at the sites. We hypothesised that exercise habits, changes in mood profile and effective temperatures during the session, and physical exertion during the climatic terrain cure would affect salivary cortisol levels. Subjects were 30 (spring) and 29 (autumn). Multiple linear regression analyses were performed to examine the determinants of the change in salivary cortisol levels. In the mountain setting, salivary cortisol was elevated, even though the sessions took place in the descending phase of the circadian salivary cortisol variation; however, the post-session cortisol increase was not significant. Increased post-session salivary cortisol was significantly associated with female gender, older age, higher BMI, lower body fat, less daily physical activity, increased blood lactate, increased ‘Tension-Anxiety’ and ‘Depression-Dejection’ moods, and decreased ‘Anger-Hostility’ mood. The increase in cortisol may have been due to older age, a predominance of females, and the increased blood lactate due to the mountainous terrain. In the flat park, the significant decrease in postsession salivary cortisol was related to the descending circadian phase of circadian cortisol variation and the low physical demands of the sessions.
Damage and Fragmentation of Rock Under Multi-Long-Hole Blasting with Large Empty Holes
Authors: Lan Riyan , Cheng Ruishan , Zhou Zilong , Chen Lu , Wang Peiyu , Wang Zhen 
Published: May 2024

AbstractThe technique of multi-long-hole blasting with large empty holes has been used in practice to break rock mass. However, the damage mechanism of rock mass surrounded by empty holes and boreholes under this type of blasting has not yet been well-understood and identified, which may lead to inappropriate design of the configurations of empty holes for multi-long-hole blasting. The present study investigates the damage modes and mechanism of rock mass under multi-long-hole blasting with large empty holes by conducting a field test and numerical simulations. The results show that multi-long-hole blasting with empty holes mainly causes compressive damage of rock mass around boreholes, reflected tensile damage near empty holes and ground surface, bending-induced tensile damage between empty holes and boreholes, shear damage along the side tangents and bottom of empty holes and boreholes, and tensile damage along the connection of boreholes caused by the superposition of stress waves. In addition, parametric studies are conducted to examine the effects of depths and diameters of empty holes and the spacing between boreholes and empty holes on the damage and fragmentation of rock mass under blast loads. It is found that the flexural stiffness and confined levels of rock mass can be greatly influenced by the variation of configurations of empty holes, which thus induces different damage and fragmentation under multi-long-hole blasting. Analytical formulas for the evaluation of shear and bending-induced damage of rock mass under multi-long-hole blasting are finally proposed to provide references for the design of empty holes in multi-long-hole blasting.