bluuebunny/crossref_metadata_2025_split huggingface dataset:
Application of Short-Range Lidar in Wind Shear Alerting
Authors: Chan P. W. , Lee Y. F. 
Published: November 2011

Abstract
Long-range lidar systems have been used operationally at the Hong Kong International Airport for wind shear alerting. They are used for monitoring the headwinds over the last 3 n mi of all of the runway corridors of the Hong Kong International Airport (HKIA). This paper discusses the results of a trial of using short-range lidar (SRL) in the alerting of wind shear over a particular runway corridor by performing more frequently updated wind measurements over a specific section of this corridor in which many wind shear reports are received. The radial resolution of the lidar is 75 m and the data are updated every 20 s. Three different ways of wind shear alerting based on SRL’s data are studied, namely, the deviations of the measured radial velocities from the uniform background flow (the “velocity fluctuation”), eddy dissipation rate (EDR), and autocorrelation of radial velocity. The performance of these methods is studied by comparing with the pilot wind shear reports. The velocity fluctuation has the best skill in capturing the wind shear reports. By combining the wind shear alerts from SRL with those from the Wind Shear and Turbulence Warning System (WTWS), it is possible to achieve a probability of detection (POD) of pilot wind shear reports of about 90%, with a percentage of time on alert (PTA) of about 10% only. This even outperforms the existing overall wind shear alerting service (WTWS plus subjective wind shear warnings issued by aviation weather forecasters) by significantly reducing PTA. As such, the present study shows that it is possible to combine wind shear alerts from SRL and WTWS for automatic wind shear alerting without the need of human intervention, at least for a particular runway corridor of HKIA.
Urea-induced Direct Synthesis of Nanostructured α-Ni(OH)2 on Nickel Foam
Authors: Lv Sa , Xing Shuangxi 
Published: November 2011

Abstract
A convenient hydrothermal route was designed for the direct synthesis of nanostructured α-Ni(OH)2 on nickel foam in an aqueous solution only containing Ni(NO3)2 and urea. The obtained urchin-like Ni(OH)2 displayed good electrochemical activity with a maximum specific capacitance of 103 mA h g−1 at a current density of 2.5 A g−1.
Rapid Access to 3-Aryltetralin Skeleton via C(sp3)–H Bond Functionalization: Investigation on the Substituent Effect of Aromatic Ring Adjacent to C–H Bond in Hydride Shift/Cyclization Sequence
Authors: Mori Keiji , Sueoka Shosaku , Akiyama Takahiko 
Published: November 2011

Abstract
The concise construction of 3-aryltetralin skeleton via hydride shift mediated C–H bond functionalization was achieved. In this process, the benzylic [1,5]-H shift occurred smoothly to furnish tetralin derivatives in good to excellent chemical yields. The electronic and steric properties of the aromatic ring adjacent to the C–H bond influenced significantly the reactivity of this transformation.
Reconstructions in ultrasound modulated optical tomography
Authors: Allmaras Moritz , Bangerth Wolfgang 
Published: November 2011

Abstract
We introduce a mathematical model for ultrasound modulated optical tomography and present a simple reconstruction scheme for recovering the spatially varying optical absorption coefficient from scanning measurements with narrowly focused ultrasound signals. Computational results for this model show that the reconstruction of sharp features of the absorption coefficient is possible. A formal linearization of the model leads to an equation with a Fredholm operator, which explains the stability observed in our numerical experiments.
Clinical Features of Cardio-Renal Syndrome in a Cohort of Consecutive Patients Admitted to an Internal Medicine Ward
Authors: Fabbian F , Pala M , De Giorgi A , Scalone A , Molino C , Portaluppi F , Mikhailidis D.P , Manfredini R 
Published: November 2011

Introduction:Cardiorenal syndrome (CRS) is a disorder of the heart and kidney whereby interactions between the 2 organs can occur. We recorded the clinical features of CRS in patients consecutively admitted to an Internal Medicine ward.Patients and Methods:We retrospectively analyzed the anthropometric, history, clinical, biochemical and treatment characteristics in 438 out of 2,998 subjects (14.6%) admitted to our unit (from June 2007 to December 2009), diagnosed with CRS, according to Acute Dialysis Quality Initiative (ADQI) recommendations. Estimated glomerular filtration (eGFR) was calculated using several equations: MDRD (Modification of Diet in Renal Disease; 2 variations GFRMDRD186, GFRMDRD175), Mayo, Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) and Cockroft-Gault.Results:Mean age was 80±8 years, 222 (50.6%) were males, 321 (73.2%) were smokers, 229 (52.2%) were diabetic, 207 (47.2%) had a history of acute myocardial infarction, 167 (38.1%) had angina, 135 (30.8%) were affected by cerebrovascular disease, 339 (77.3%) had peripheral arterial disease. CRS was type 1 in 211 cases (48.2%), type 2 in 96 (21.9%), type 3 in 88 (20.1%), type 4 in 29 (6.6%) and type 5 in 14 (3.2%). eGFR, calculated by different formulae, ranged between 31 and 36 ml/min/1.73 m2. GFR was lower in CRS type 3 than in the other types, and the values ranged between 24 and 27 ml/min/1.73 m2. Mean hospital length-of-stay (LOS) was 9.8±6.3 days. Diuretics were the most prescribed medication (78.7%); only 5 patients underwent haemodialysis.Conclusions:CRS is common, especially in the elderly. CRS Type 1 was the prevalent subset and patients had stage 3-4 renal insufficiency. Results obtained from the GFR equations were similar although the Mayo equation tended to overestimate the eGFR.
Association of Awareness, Intrapersonal and Interpersonal Factors, and Stage of Dietary Change with Fruit and Vegetable Consumption: A National Survey
Authors: Van Duyn Mary Ann S. , Kristal Alan R. , Dodd Kevin , Campbell Marci K. , Subar Amy F. , Stables Gloria , Nebeling Linda , Glanz Karen 
Published: November 2011

Purpose. To examine associations of awareness, intrapersonal and interpersonal factors, and stage of change with consumption of fruits and vegetables. Design. Nationally representative, random digit dial survey conducted in 1997 with a response rate of 44.5%. Psychosocial correlates of fruit and vegetable consumption were assessed using regression analyses. Setting. United States. Subjects. A total of 2605 adults who were 18 years and older. Measures. Awareness of the “5 A Day for Better Health” program and its message, along with stage of change; taste preferences; self-efficacy; and perceived benefits, barriers, threats, social support, and norms related to fruit and vegetable consumption. Results. Awareness and intrapersonal and interpersonal factors explained 24% of the variance in fruit and vegetable consumption beyond the 9% explained by demographic characteristics. Knowledge of the 5 A Day message was associated with a 22% increase in fruit and vegetable consumption. Self-efficacy for eating fruits and vegetables and taste preferences (affect) were the factors most consistently and strongly associated with both higher consumption and higher likelihood of being in action or maintenance stages of change. Affect and perceived barriers were more strongly associated with increased vegetables and salad than fruit. Conclusions. Dietary intervention programs to increase fruit and vegetable consumption should emphasize the 5 A Day message, increased self-efficacy, and ways to make vegetables more palatable and easily accessible. Understanding the factors that influence dietary choices should be used when designing dietary interventions.
Selenium vs Control for Graves Ophthalmopathy in a Selenium-Sufficient Area
Authors: Ahn Hwa Young , Lee Min Joung , Jung Kyong Yeun , Kim Hyo-Jeong , Jung Eun Hye , Chung Chae Won , Kim Kyungsik , Jang Jinsun , Park Young Joo , Lee Jeong Kyu , Cho Sun Wook 
Published: February 2025

ImportanceGraves ophthalmopathy significantly diminishes patients’ quality of life due to its immune-mediated inflammatory effects on the orbital tissues. Selenium, with its antioxidative properties, has shown potential for improving Graves ophthalmopathy progression and quality of life (QOL); however, its effectiveness in selenium-sufficient regions is not well established.ObjectiveTo determine whether selenium supplementation improves QOL in patients with mild to moderate Graves ophthalmopathy in selenium-sufficient regions.Design, Setting, and ParticipantsThe Efficacy of Selenium Supplementation for Mild-to-Moderate Graves’ Ophthalmopathy in a Selenium-Sufficient Area (SeGOSS) trial was a randomized, open-label multicenter study. Eighty-four patients with mild to moderate Graves’ ophthalmopathy were enrolled; 70 completed the study. Participants were selected based on Graves ophthalmopathy diagnosis and sufficient selenium levels. Data were analyzed from October 2023 to March 2024.InterventionsParticipants received selenium supplementation combined with vitamin B complex for 6 months.Main Outcomes and MeasuresThe primary outcome was improvements in Graves ophthalmopathy QOL (GO-QOL) scores at 6 months. Secondary outcomes included changes in GO-QOL scores at 3 months, the proportion of patients showing improvement based on GO-QOL scores, clinical activity score, and ophthalmic examinations at 3 months and 6 months, and changes in thyroid autoantibodies at 3 months and 6 months.ResultsThere was no improvement in changes in the total GO-QOL scores between the selenium group (31 female patients [83.8%] and 7 male patients [16.2%]; mean [SD] age, 40.8 [11.7] years) and control group (24 female patients [72.7%] and 9 male patients [27.3%]; mean [SD] age, 42.9 [14.2] years) for the primary outcome at 6 months (mean [SD], 12.2 [22.5] vs mean [SD], 11.2 [20.2]; difference, 0.9; 95% CI, −9.3 to 11.3; P = .85). However, at 3 months, a higher proportion of patients in the selenium group showed improved GO-QOL scores compared with the control group (78.4 vs 48.5%; difference, 0.30; 95% CI, 0.08-0.51; P = .01). The selenium group also had higher rates of improvement in proptosis reduction (49.5 vs 15.1%; difference, 0.31; 95% CI, 0.11-0.51; P = .01) at 3 months, though these effects were not sustained at 6 months.Conclusions and RelevanceThese results suggest that selenium supplementation did not improve QOL or clinical parameters in patients with mild to moderate GO in selenium-sufficient regions at 6 months. Some potential QOL benefits noted at 3 months supports consideration of further investigation of selenium for patients seeking treatment for Graves ophthalmopathy .Trial RegistrationClinical Research Information Service Identifier KCT0004040
Enhancing Ion Transport and Suppressing Electron Conduction: a Hybrid Interlayer for Stable Garnet‐Based Solid‐State Batteries
Authors: Xiang Xing , Du Congkun , Zhao Rufang , Zhao Zhenzhen , Ji Xin , Liu Dongyang , Li Zhihan , Wang Huihu , Zhang Yanhua , Zhao Yun , Liu Xinghui , Chen Fei , Wu Jian‐Fang 
Published: February 2025

AbstractCubic doped Li7La3Zr2O12s (LLZOs) are promising solid‐state electrolytes (SSE) for solid‐state lithium batteries due to their excellent lithium‐ion conductivities and electrochemical stability. However, they face the challenge of lithium dendrite growth. Here, a hybrid interlayer–alloy phases (LiZn, Li22Sn5, Li5Sn2) and Li2O–is created by an in situ reaction between the modified layer Zn2SnO4 (ZSO) on LLZO and lithium metal anodes. Benefiting from the synergistic effect of the fast lithium‐ion conduction of the Li5Sn2 alloy, the strong affinity between the LiZn alloy and LLZO, and electronic insulator Li2O, a super‐conformal structure at the Li/ZSO‐LLZO interface is formed, effectively inhibiting the formation of lithium dendrites in ZSO‐LLZO SSE. Consequently, Li/ZSO‐LLZO/Li symmetric batteries deliver stable cycling (2500 h under 0.3 mA cm−2 at 25 °C and 6000 h under 0.5 mA cm−2 at 60 °C) performances with superhigh critical current densities of 2.5 mA cm−2 at 25 °C and 3.8 mA cm−2 at 60 °C. Moreover, the LiFePO4/ZSO‐LLZO/Li battery delivers capacities of 137.45 mAh g−1 under 1 C for 500 cycles and 111.78 mAh g−1 under a high rate of 2 C for 300 cycles. This work with a hybrid interlayer opens a boulevard for designing energy‐dense and long‐life solid‐state batteries.
Enhanced quantitative detection of delamination defects in large‐tow carbon fiber composites using pulsed thermography
Authors: Sun Hongyu , Yang Shuang , Wang Jun , Wu Chaoqun , Chen Xi , Wang Jingsheng , Chen Kaiwen 
Published: February 2025

AbstractLarge‐tow carbon fiber fabrics generate considerable structured background texture noise in infrared thermographic inspections due to their nonuniform thermal properties. The presence of such noise poses notable challenges to the reliable and precise detection of defects. To address this issue, this article proposes a defect detection method that integrates the frame averaging difference (FAD) algorithm and principal component analysis (PCA). The method utilizes FAD to remove nontime‐varying noise, improving the contrast‐to‐noise ratio of defect signals. It then employs PCA to separate background texture noise. Building upon this foundation, a region growing segmentation (RGS) algorithm based on fuzzy affinity (FA) was introduced. The algorithm integrates a spatial distance function based on both pixel intensity and spatial proximity, significantly enhancing the accuracy of defect region segmentation. To validate the effectiveness of the proposed method, artificial delamination defects were simulated by embedding Teflon films between layers. Large‐tow carbon fiber fabric composite laminates were then fabricated as test samples. The experimental results demonstrate that the algorithm effectively reduces the error rate in defect detection for large‐tow carbon fiber composite laminates. This study provides a practical technical solution for the nondestructive testing of large‐tow carbon fiber composites and shows strong applicability and robustness under complex background noise conditions.Highlights
Quantitative detection of defects in large‐tow carbon fiber fabric laminates using long‐pulse infrared thermography.
A principal component analysis algorithm based on frame averaging differences was proposed.
A region growing segmentation algorithm based on fuzzy affinity was proposed.
Natural Matrine‐Integrated Pollen Delivery Systems for Allergic Contact Dermatitis Treatment
Authors: Wang Yuwei , Cai Lijun , Zhang Yuanyuan , Cong Yan , Zhao Yuanjin 
Published: February 2025

ABSTRACTAllergic contact dermatitis (ACD) is an inflammatory dermatitis with a high morbidity and recurrence rate. Scientific attention is focused on the development of safe and comfortable therapeutics of ACD. Herein, we propose a natural matrine‐integrated pollen delivery system for the ACD treatment. Sunflower pollens were collected and defatted to serve as adhesive drug carriers for matrine. Specifically, the exquisite porous and hollow structures of the pollen shells can absorb matrine and realize the sustained drug release. Besides, the prickly surface morphology can strongly adhere to the inflamed skin sites, which can prolong the duration of the drug. By utilizing them in an ACD model and an acute pruritus model of mice, we have demonstrated that these matrine‐integrated pollen shells can decrease the swelling degree of mice ears and weight loss, down‐regulate inflammatory response, and improve the scratching times. These results indicate that our matrine‐integrated pollen delivery systems have great potential to serve as natural topical preparations for skin disease therapy.
Multifunctional Silk and Gelatin Composed Microneedle Patches for Enhanced Wound Healing
Authors: Fan Lu , Wang Li , Wang Xiaoju , Li Minli , Gu Hongcheng , Zhang Hongbo 
Published: February 2025

ABSTRACTWound healing has been a continuous critical focus in clinical practice, posing the ongoing challenges and burdens to patients. Current attempts tend to develop multi‐drug loaded patches with spatial design. Herein, we present a multifunctional microneedle patch that integrates different drugs into separated regions for wound treatment. The microneedle patch is composed of silk fibroin‐methacryloyl (SilMA) as the base, loaded with silver nanoparticles (AgNPs) and has gelatin methacryloyl (GelMA) tips loaded with vascular endothelial growth factor (VEGF). The backing is endowed with antimicrobial properties by AgNPs act as an antimicrobial barrier against bacterium invasion. In addition, the tips encapsulated with VEGF can effectively promote cell proliferation and angiogenesis, which is favorable for wound repair. Based on these characteristics, such an integrated microneedle system significantly prevented bacterial infection and promoted wound healing in vivo. Therefore, it is conceived that such a system can find more practical values in wound healing and other fields.
MRI-Based Brain Tumour Detection and Classification Using Random Forest Algorithm
Authors: Jareena Begum D. , Chokkalingam S. P. 
Published: February 2025

Abstract
A brain tumour develops when cells in the brain multiply abnormally and out of control. The possibility of fatality makes this growth dangerous. The brain regulates everything from memory to vision to emotions. Recognizing these tumours is a challenging and complex task due to their location, size, and shape. There have been a number of successful attempts to enhance detection. However, the current level of precision is insufficient. This study details a method with a high likelihood of success in identifying brain cancers. The approach is implemented in Python LAB by use of an image segmentation technique and a classifier. One such classifier is the Random Forest Algorithm. The Principal Component Analysis (PCA) and the Discrete Wavelet Transform (DWT) are also employed. The created method is put to the test using a dataset available on the Kaggle platform. The acquired results were approximately 97.68% accurate. A confusion matrix and a comparison of the developed method to other research in the literature are included in the investigation to facilitate the implementation of the proposed strategy in image testing. This Research shows that the offered system is superior to others in terms of detection rate, false positive rate, and recall. Results from this study showed that the developed method was effective at detecting brain tumours due to its high levels of accuracy, precision, and recall. According to the proposed strategy, it is essential to provide professionals who diagnose brain tumours with access to such technology.
PPP1R13L drives cervical cancer progression by suppressing p63-mediated PTEN transcription
Authors: Wang Anjin , Liu Xuelian , Liang Ziyan , Yao Shijie , Wan Shimeng , Ren Hang , Gao Yang , Wang Hua , Cai Hongbin 
Published: February 2025

Abstract
PPP1R13L is a conserved inhibitor of p53, selectively regulating a subset of p53 target genes. Previous studies have reported that PPP1R13L promotes cervical cancer progression, yet its precise mechanism remains unclear and warrants further investigation. In this study, we utilized public databases to reveal the correlation between PPP1R13L and tumor progression pathways. Subsequently, we performed functional assays both in vitro and in xenograft models to assess the impact of PPP1R13L on cervical cancer. Our results demonstrate that PPP1R13L promotes cervical cancer cell proliferation, epithelial-mesenchymal transition, cycle progression, and glycolysis via the PTEN/AKT/mTOR pathway. Mechanistically, PPP1R13L regulates the transcription of PTEN through its Ank-SH3 domain interaction with p53 family, p53 and p63. In 293T cells, p53 originally exhibits significantly higher transcriptional activity than p63. However, in cervical cancer—where E6 continuously degrades p53 and p63 is highly expressed—p63 demonstrates a transcriptional activity for PTEN that is comparable to, or even surpasses, that of p53, depending on E6 expression levels. Additionally, in C33A, an HPV-negative cervical cancer cell line, the p53 R273C mutation causes PPP1R13L to exert an opposite effect, and p63 is shown to be inhibited by PPP1R13L independently of p53. Finally, the response elements of PPP1R13L-regulated p53 family target genes were experimentally validated on p63 for the first time. This provides a sequence basis for the selective regulation of p53 family target genes by PPP1R13L. In summary, we underscore the specificity of the PPP1R13L/p63/PTEN axis in cervical cancer and propose that PPP1R13L holds potential as a therapeutic target for cervical cancer treatment.

Graphical abstract
Efficient Quantum Gibbs Samplers with Kubo–Martin–Schwinger Detailed Balance Condition
Authors: Ding Zhiyan , Li Bowen , Lin Lin 
Published: February 2025

Abstract
Lindblad dynamics and other open-system dynamics provide a promising path towards efficient Gibbs sampling on quantum computers. In these proposals, the Lindbladian is obtained via an algorithmic construction akin to designing an artificial thermostat in classical Monte Carlo or molecular dynamics methods, rather than being treated as an approximation to weakly coupled system-bath unitary dynamics. Recently, Chen, Kastoryano, and Gilyén (arXiv:2311.09207) introduced the first efficiently implementable Lindbladian satisfying the Kubo–Martin–Schwinger (KMS) detailed balance condition, which ensures that the Gibbs state is a fixed point of the dynamics and is applicable to non-commuting Hamiltonians. This Gibbs sampler uses a continuously parameterized set of jump operators, and the energy resolution required for implementing each jump operator depends only logarithmically on the precision and the mixing time. In this work, we build upon the structural characterization of KMS detailed balanced Lindbladians by Fagnola and Umanità, and develop a family of efficient quantum Gibbs samplers using a finite set of jump operators (the number can be as few as one), akin to the classical Markov chain-based sampling algorithm. Compared to the existing works, our quantum Gibbs samplers have a comparable quantum simulation cost but with greater design flexibility and a much simpler implementation and error analysis. Moreover, it encompasses the construction of Chen, Kastoryano, and Gilyén as a special instance.
Twisted Verlinde Formula for Vertex Operator Algebras: The Prime Case
Authors: Dong Chongying , Lin Xingjun 
Published: February 2025

Abstract
For a rational and

$$C_2$$

C
2

-cofinite vertex operator algebra V with an automorphism group G of prime order, the fusion rules for twisted V-modules are studied, a twisted Verlinde formula which relates fusion rules for g-twisted modules to the S-matrix in the orbifold theory is established. As an application of the twisted Verlinde formula, a twisted analogue of the Kac-Walton formula is proved, which gives fusion rules between twisted modules of affine vertex operator algebras at positive integer levels in terms of Clebsch–Gordan coefficients associated to the corresponding finite dimensional simple Lie algebras.