bluuebunny/crossref_metadata_2025_split huggingface dataset:
Glomerular Diameter Measurements on Light Microscopy: A New Parameter Available to Pathologists and its Utility in IgA Nephropathy
Authors: Manocha Anisha , Fathima Nigar , Gowrishankar Swarnalata 
Published: May 2024

Background:With the availability of whole slide digital scanners, fairly accurate glomerular diameter (GD) measurements are now possible on light microscopy. The value of these measurements in prognosis and diagnosis of immunoglobulin A nephropathy (IgAN) have not been studied widely. IgAN is a major cause of end-stage renal disease (ESRD) worldwide, and its progression is currently assessed using Oxford scores, serum creatinine, and 24-h urinary protein. We aimed to correlate the mean and maximum GDs with serum creatinine, 24-h urinary protein, and Oxford scores in patients with IgAN.
Materials and Methods:One hundred biopsies of IgAN with a minimum of eight viable glomeruli were collected along with data of their 24-h proteinuria, serum creatinine, and Oxford scores. The slides were scanned using the Philips IntelliSite Pathology Solution-Ultra Fast Scanner. Mean GD of each glomerulus was calculated as the mean of two measurements, that is, the maximal diameter of the glomerulus and the maximal chord perpendicular to the maximal diameter. Maximum GD was also recorded for each case. The Spearman rho/Pearson R correlation coefficient was used to make this correlation. P-values <0.05 were considered statistically significant.
Results:The mean age of the patients was 34.67 ± 12.03 years, and they showed a male preponderance. The overall mean GD was 151.82 ± 28.69 µm, and maximum GD was 205.40 ± 32.76 µm. No statistically significant correlation was observed between the mean or maximum GD and the 24-h proteinuria, serum creatinine levels, and Oxford scores.
Conclusion:GD in IgAN does not correlate with proteinuria, serum creatinine, or Oxford scores.
The politics of voicelessness: voices of community elders in ethic and religious minorities in the Philippines
Authors: Morales Sheryl R , Morales Roque S , Sagun Randy D 
Published: May 2024

The study aims to examine the phenomena of minoritization, which involves the imposition of the beliefs and culture of dominant groups onto minority groups, leading to social exclusion and conflicts. The study utilizes data analysis to identify themes related to the process of minoritization. The study illustrates that minoritization occurs when dominant groups perceive themselves as superior and endeavor to dominate others, resulting in violence, oppression, and social exclusion. This study focuses on the perspectives of grassroots voices, going beyond traditional inquiries on equalities between different groups to provide a deeper insight into the systemic challenges encountered by minority communities. It emphasizes attributes such as dominant groups imposing their beliefs on others, perceiving them as inferior, and forcing them to adopt their culture or traditions. To address the issue of minoritization, the study emphasizes the importance of carrying out dialogues at all levels, promoting understanding across various cultures and religions, implementing policies that protect the rights of minority groups, and preventing systematic minoritization. This study enhances broader discussions on inclusivity and equality through exploring its findings in relation to global issues of prejudice. It advocates for the increased recognition and valued of minority voices in society. This emphasizes the need for holistic strategies that promote mutual respect among different communities and prevent conflicts arising from social exclusion.
INCLUSÃO DE ALUNOS COM AUTISMO EM SALA DE AULA E O PLANO EDUCACIONAL INDIVIDUALIZADO (PEI)
Authors: Battistello Viviane Cristina de Mattos , Lisboa Elise Ribas , Martins Rosemari Lorenz 
Published: May 2024

A inclusão de alunos com autismo em classes regulares ainda apresenta muitos desafios. O plano educacional individualizado (PEI) é uma ferramenta norteadora que pode ser muito útil no processo de inclusão. Considerando-se essa importância, este trabalho teve como objetivo geral refletir sobre as possibilidades do PEI diante dos processos formativos de estudantes com TEA no ensino regular e, como objetivos específicos, compreender a função do PEI e verificar como ele pode ser operacionalizado no contexto de sala de aula. Para responder esses objetivos, realizou-se uma pesquisa bibliográfica sobre o tema. Os estudos analisados indicam que o conceito do PEI ainda é recente no panorama brasileiro e, embora tenha amparo em políticas públicas educacionais, ainda é pouco utilizado nas escolas. E, quando é usado, além de ser denominado de formas diferentes, sua estrutura também não é padronizada. Ademais, verificou-se que, muitas vezes, faltam informações para elaborar um plano efetivo. Nesse sentido, fica evidente a necessidade de ampliar os estudos sob o viés de padronizá-lo minimamente e de operacionalizá-lo, visto que há divergências em relação à efetivação e ao monitoramento dos aspectos relacionados à vida escolar dos alunos com TEA.
AUTORIA TEXTUAL NA EDUCAÇÃO PROFISSIONAL E TECNOLÓGICA
Authors: Ferreira Santos Elza , Souza da Silva Débora 
Published: May 2024

Este artigo trata das inquietações que acometem estudantes do Ensino Médio Integrado (EMI) diante da escrita acadêmica. Um dos desafios da Educação Profissional e Tecnológica (EPT) é oferecer uma formação integrada, politécnica e omnilateral e isso pressupõe, dentro do ensino de Língua Portuguesa, compreender práticas de linguagem relacionadas à interação e à autoria. Em outras palavras, as aulas da disciplina devem ir além do domínio da norma culta e da produção de relatórios. Assim, mediante à aplicação de um questionário com questões abertas em uma turma do segundo ano de Química do EMI do Campus Aracaju do Instituto Federal de Sergipe (IFS) pode-se identificar tensões e preocupações acerca da constituição da autoria em textos escritos produzidos por educandos. Esses registros serviram de base, neste artigo, para a interpretação das marcas autorais dos sujeitos na produção textual desenvolvida e para a necessidade de serem construídas efetivamente práticas pedagógicas integradoras que insistam em produções escritas acadêmicas com indícios de autoria.
ENSINAR E APRENDER EM UMA SOCIEDADE DO CONHECIMENTO: REPENSANDO ALGUNS PRINCÍPIOS DIDÁTICO-PEDAGÓGICOS PIAGETIANOS
Authors: Orth Miguel Alfredo , Medeiros Claudia Escalante Medeiros 
Published: May 2024

O presente artigo objetiva discutir alguns princípios didáticos e pedagógicos piagetianos, como: Construção, Adaptação e Equilibração e que, norteiam a ação educativa, tendo como contexto maior a sociedade do conhecimento. Justifica-se essa escolha, pois intencionamos auxiliar os educadores e os aprendizes em seus processos de ensino e de aprendizagem ativos, além de ajudá-los a entender melhor o seu método de ensino e de aprendizagem. Metodologicamente, optamos em, nos orientarmos pela revisão de literatura e no estudo de alguns documentos da área. Entre os principais resultados, apresentamos um conjunto de princípios didáticos e pedagógicos e suas categorias para ajudar os professores a se apropriarem de um método ativo de ensinar e de aprender, como o método construtivista e com o papel ativo dos aprendizes neste processo. Desse modo, foi possível discutir à temática, do uso de alguns princípios e categorias piagetianos, para se formar alunos/professores no ensino e na aprendizagem a distância, e vinculando a um referencial teórico potente a fim de explicitar os objetivos e a discussão das categorias de: interação, assimilação e acomodação, problematizando-as em uma sociedade do conhecimento.
CONCEPÇÕES DOCENTES EM RIO BRANCO-AC: O (DES)CONHECIMENTO DA POLÍTICA NACIONAL DE EDUCAÇÃO ESPECIAL INCLUSIVA
Authors: Pacífico Barbosa Alysson Vinícius , Lopes de Oliveira Costa Ademárcia 
Published: May 2024

Este artigo tem como objetivo analisar as concepções docentes acerca da Política Nacional de Educação Especial e Inclusiva em Rio Branco/Acre. A pesquisa, de abordagem qualitativa, do tipo exploratória-descritiva, por meio da revisão bibliográfica e da pesquisa de campo, contou como técnicas de coletas, o questionário fechado e a entrevista semiestruturada. A população e a amostra correspondem a 18 (dezoito) docentes do Atendimento Educacional Especializado – AEE da Rede Estadual de Ensino de Rio Branco/Acre. Para fundamentar o estudo, utilizou-se teóricos, como, Carvalho (2004, 2008), Góes (2007), Jannuzzi (2017), Kassar (2011), Laplane (2007), Lima (2006), Mantoan (2011, 2015), Mazzotta (2011), Mendes (2010), Pires (2006), dentre outros. Além disso, fez-se uso de fontes documentais que abordam o Atendimento Educacional Especializado, como a Lei de Diretrizes e Bases da Educação Nacional – LDBEN n° 9.394 (Brasil, 1996); a Portaria Normativa n° 13 (Brasil, 2007); a Política Nacional de Educação Especial na Perspectiva da Educação Inclusiva (Brasil, 2008); a Resolução n° 4 (Brasil, 2009); o Manual de Orientação: Programa de Implantação de Sala de Recursos Multifuncionais (Brasil, 2010); o Decreto nº 7.611 (Brasil, 2011) e a Instrução Normativa n° 001, de 30 de janeiro de 2018 (Acre, 2018). Os dados foram analisados com o auxílio da Análise de Conteúdo (Bardin, 2016). Explicita-se que as concepções giram em torno da Educação Inclusiva como um movimento amplo de caráter legal, social e político, voltado para a inclusão educacional dos estudantes público-alvo da modalidade de Educação Especial nas escolas regulares de ensino.
Índice de calidad nutricional en suelos cacaoteros de la subregión cordillera de Nariño
Authors: Cortés Delgadillo Diego Leonardo , Lerma Lasso Jose Libardo , López Rendon Juan Fernando , Meneses Buitrago Diego Hernán , Martínez Pachón Eliana 
Published: May 2024

La calidad del suelo sirve para determinar si un sistema productivo es sostenible. El objetivo de este estudio es estimar un índice de calidad de nutrientes del suelo para cacao [ICNs], mediante la estandarización de variables, desarrollo de funciones de puntuación y asignación de pesos relativos. Se estandarizaron los macronutrientes y micronutrientes, acidez (pH), contenido de materia orgánica [%MO] y saturación de aluminio [%S.Al]. Los ICNs se analizaron de acuerdo con las unidades cartográficas del suelo [UCS]. Se utilizaron algoritmos de aprendizaje automático asistido por computadora para la calibración de un modelo de predicción espacial del ICNs. Se encontró que el 70,6 % de los sitios se clasificaron con ICNs medio (0,4 -0,7), el 23,8 % fueron bajos y el 5,6 % fueron altos. Las UCS con ICNs más altos también tienen mejor retención de agua, una limitada profundidad efectiva y se encuentran en pendientes pronunciadas; aquellas con ICNs más bajos se vieron afectados por deficiencias de MO y contenido de macronutrientes, pero esos sitios se encontraron en zonas más accesibles. Se obtuvo el mapa de distribución espacial del ICNs que ofrece la representación visual detallada de las áreas con mayor y menor aptitud nutricional para el cultivo de cacao. El ICNs permite entender la oferta nutricional del suelo en la subregión cordillera de Nariño, pero integrar factores adicionales, como la profundidad del suelo, el relieve y la disponibilidad de agua, mejoraría el monitoreo y permitiría un manejo más efectivo de los cultivos de cacao en consonancia con los principios de la sostenibilidad ambiental.
Ecology and social behavior of the midday gerbil Meriones meridianus: Insights from long-term research in the wild and seminatural environments
Authors: Gromov Vladimir S. 
Published: May 2024

The present review provides a compilation of the published data on the ecology and social behavior of midday gerbils. Both field studies and observations under semi-natural conditions provide evidence that the midday gerbil is a nocturnal, primarily granivorous rodent that lives in highly seasonal habitats. A typical feature of the midday gerbils’ spatial organization is formation of multi-male–multi-female associations (breeding colonies) in which male home ranges overlap each other and with female ranges to a great extent, while females tend to occupy exclusive home ranges. The mating system of this species can be defined as polygynandry or promiscuity; males appear to compete for access to receptive females. The social structure in the midday gerbil is primarily based on aggressive interactions between conspecifics resulting in a dominance hierarchy among males and site-dependent dominance among females, especially during the breeding season. After the cessation of reproduction, a tendency towards more pronounced gregariousness appears, and midday gerbils form wintering groups; gerbils, however, lead solitary lives within these groups. Overall, the data presented expand our understanding of socio-ecology of gerbils.
Efficacy of the drug maribavir according to clinical studies
Authors: Drachuk E. S. , Gubanova A. A. , Haidbayev I. , Burmistrova V. N. , Andreyanova K. A. , Hertek Yu. A. , Tuchina V. E. , Kuzmina S. V. , Kulikova O. V. , Borodina A. R. , Petrakov A. A. , Om S. M. , Babyuk V, V. 
Published: May 2024

Modern medicine has a high demand for new drugs for the prevention and treatment of cytomegalovirus (CMV) infection. This review discusses maribavir — an oral antiviral drug with selective multimodal anti-CMV activity for the treatment of adults and children with post-transplant CMV infection resistant to traditional anti-CMV therapy. Despite numerous clinical trials of maribavir, the results of its effi cacy are ambiguous. Alongside successful studies indicating high effi cacy of the drug under review, there are data from statistically unsuccessful studies. The aim of this review is to examine the mechanism of its action on cytomegalovirus infection, viral sensitivity and cross-resistance mechanisms, as well as to summarize the results of clinical trials of the drug.
Pathophysiological aspects of morphological changes in the structure of atrioventricular valves leafl ets in diabetes mellitus
Authors: Krylov V. V. , Ragimov M. R. , Misnikova I. V. 
Published: May 2024

The increasing number of patients with diabetes in the structure of comorbid cardiothoracic patients necessitates a more detailed study of the pathophysiological mechanisms of the modifying infl uence of diabetes, taking into account new scientific data. This allows for a more systematic view of processes that were previously the prerogative of specialists. Content. A modern perspective on the pathophysiological mechanisms of diabetes on cardiac structures is presented, with a description of the two most signifi cant pathological syndromes — diabetic cardiomyopathy and changes in the morphological structure of the atrioventricular valve leafl ets. The expansion of the endocrinologist’s role in the examination and treatment of cardiothoracic patients is justifi ed. Conclusion. A systemic approach to the problem of diabetes in cardiothoracic surgery, incorporating a multidisciplinary approach and active involvement of endocrinologists at all stages of the treatment process, will improve treatment outcomes for cardiothoracic patients and reduce their postoperative recovery times.
Dishomeostatic phenomena in acute pancreatitis of variable severity
Authors: Vlasov A. P. , Al-Kubaisi Sh.-Ah. S. , Vlasova T. I. , Myshkina N. A. , Sinyavina K. M. , Khozina E. A. , Khudaiberenova O. D. , Khachaturov M. Yu. 
Published: May 2024

Acute pancreatitis remains one of the most dangerous pathologies in the structure of emergency abdominal surgery. This is due to many reasons, including an increase in the frequency of destructive forms of the disease, high mortality, and frequent unfavorable outcomes. The aim of this study was to investigate a number of leading components of homeostasis in patients with acute pancreatitis of varying severity. A retrospective study was conducted on 50 patients with acute pancreatitis of diff erent severity levels who were hospitalized at the Republican Clinical Hospital named after S.V. Katkovа (Saransk, Russia). The patients were divided into groups: the fi rst group (control, n = 30) consisted of patients with mild acute pancreatitis, and the second group (main, n = 20) consisted of patients with severe acute pancreatitis. The study evaluated the endogenous intoxication syndrome, the activity of lipid peroxidation and phospholipase systems, microcirculation status, liver function, and the activity of the coagulation-lytic blood system. The results showed that in the early stages of acute pancreatitis, several pathological processes were observed: the development of endotoxemia syndrome, activation of lipid peroxidation and phospholipase systems, microcirculation disorders, changes in the coagulation and fibrinolytic links of the hemostasis system, and liver function suppression. The severity of these disorders was associated with the severity of the pathology. In cases of mild severity, the changes in the parameters studied were reversible, while in severe cases they were stable and oftenirreversible. The presence of toxemia, oxidative stress, dysmicrocirculation, and hemostatic disorders should be considered as risk factors for disease progression and complications.
Clinical experience of using a high-intensity erbium laser for the treatment of chronic wounds
Authors: Zaitsev A. E. , Asanov O. N. , Sandalov E. Zh. , Zaitseva A. V. 
Published: May 2024

Chronic wounds are a common surgical pathology. Some types of laser radiation allow for eff ective debridement of wounds and stimulation of healing processes. High-intensity erbium laser can comprehensively aff ect tissues in all phases of the wound process, leading to accelerated healing of chronic wounds. The aim of the study was to evaluate the eff ectiveness of using high-intensity erbium laser for treating patients with chronic wounds of various origins compared to traditional treatment. Material and methods: An analysis of the treatment of 144 patients with chronic wounds was conducted in two groups. In the 1st group (n = 71), a high-intensity erbium laser and dressings with water-soluble ointments were used. In the 2nd group (n = 73), standard surgical treatment with similar dressings was performed. Results were evaluated using visual assessment of wound defects, planimetry, bacteriological and cytological studies, assessment of procedure tolerability, and pain intensity before and after treatment. Results: рatients in the 1st group showed signs of healing signifi cantly earlier and more frequently achieved complete epithelialization of wounds. Laser treatment contributed to more effective decontamination of wound defects, and signs of tissue regeneration were more frequently observed in cytological images. Patients tolerated erbium laser treatment better than surgical treatment, although pain intensity after treatment did not differ between groups. Conclusion: The study confi rmed the effectiveness of using high-intensity erbium laser for treating chronic wounds. This method can be recommended for use in surgical practice alongside other technical and pharmacological tools.
Assessment of pharmacotherapy efficacy for the treatment of exacerbations of chronic obstructive pulmonary disease associated with viral infection
Authors: Shpagina L. A. , Kotova O. S. , Shpagin I. S. , Kuznetsova G. V. , Loktin E. M. , Rukavitsyna A. A. , Karmanovskaya S. A. , Panacheva L. A. , Anikina E. V. 
Published: May 2024

Justification. Knowledge of the differences in response to therapy between phenotypes of exacerbations of chronic obstructive pulmonary disease (COPD) is necessary to improve treatment outcomes. Objective: to determine the most effective additional pharmacological methods for virus-associated exacerbations of COPD. Material and methods. The study included patients hospitalized with exacerbations of COPD with viral (n = 60) and viral-bacterial (n = 60) infections, and a comparison group with exacerbations of COPD with bacterial infection (n = 60). The diagnosis of COPD was based on spirometric criteria, viral infection — according to the results of PCR-RV of sputum for RNA of respiratory viruses. Treatment was carried out in real clinical practice. The groups were comparable in the use of systemic glucocorticoids, short-acting bronchodilators. Dyspnea was assessed using the TDI index (primary endpoint), lung function (spirometry, diffusion capacity for carbon monoxide), exercise tolerance (6-minute walk test), length of hospital stay (secondary endpoints). The сorrelations were determined with the use of Cox proportional hazards model. Results. In the groups with virus-associated and viral-bacterial exacerbations, unlike bacterial exacerbations, the following types of treatment were associated with achieving TDI +1 (odds ratio — OR, 95 % confidence interval — CI): fixed triple combination (OR 2.69; 95 % CI 1.48–4.90; p = 0.010 and OR 2.74; 95 % CI 1.29–3.80; p = 0.031), inhalation of 3 % sodium chloride solution (OR 3.64; 95 % CI 1.45–5.42; p = 0.001 and OR 3.23; 95 % CI 2.15–5.43;\ p = 0.042), antiviral drugs (OR 2.91; 95 % CI 1.15–3.62; p = 0.009 and OR 2.76; 95 % CI 1.31–3.90; p = 0.008). As a result of treatment, an increase in DLco/Va, SpO2 after a 6-minute walk, and a decrease in the length of hospital stay were observed. Conclusion. Detection of virus-associated infections is a promising marker for determining indications for prescribing long-acting anticholinergic drugs and beta-adrenomimetics, inhaled corticosteroids, inhalations of hypertonic sodium chloride solution, and antiviral drugs for exacerbations of COPD.
Anlatının tiyatral olması
Authors: Erdenk Sibel , Durak Aras Melike 
Published: May 2024

Tiyatro, özellikle Batı’da, (anlatı) diegetik bakış açısından ziyade (canlandırma) mimetik açıdan ele alınagelmiş, diegesis Aristoteles’in Poetika’sından itibaren tiyatro sanatının sınırları dışında bırakılmıştır. 20. yüzyıldan günümüze dek uzanan süreçte, özellikle sahne – seyir yeri, oyuncu – seyirci ilişkisinde canlı bir deneyimi yakalamaya yönelik arayışların bir kısmı tiyatroda anlatı meselesi üzerine odaklanmaya başlamıştır. Brecht’in öykü anlatma hattını yeniden açtığı anlatı’yı dahil eden epik tiyatro kuramı ve devamında Lehmann’ın postdramatik kavramsallaştırmasıyla da tekrar sahneye çağrılan anlatının, tiyatro tarihindeki dönemsel dönüşümü hem tiyatroyu hem de performansı klasik tanımlarının dışına çıkarmıştır. Tiyatroda anlatının karakteristiğini belirleyen temel olgu, onun yeni çağın tarihsel-toplumsal koşullarıyla kurduğu ilişkinin ötesinde bir yerde, dramatik yapının estetik üstünlüğünü yok etmesi ve alternatifini kurmasında yatmaktadır. Bu çalışma, ‘anlatı’nın Antik, Epik ve Postdramatik dönem olmak üzere önemli dönüm noktalarındaki seyrini, anlatısal stratejilerle örneklemeyi amaçlamaktadır. Yöntem: Bu çalışmada anlatının dramatik tiyatro uygulamalarında kullanımına yönelik teoriden pratiğe aktarımını derecelendirme biçimi yöntemsel olarak esas alınmıştır. Sonuç: Yaşamı bir deneyim olarak tanımlayan çağımız sanatının, anlatıyı tekrar merkeze yerleştirdiği görülmektedir. Bu deneyimin tiyatronun uygulama alanında anlatı hikayeleri olarak popüler bir eğilim göstermesinin yanısıra yeni bir söz, seyirciyle kurulmak istenen yeni bir temasın arayışında olunmasından kaynaklandığı görülmektedir.