bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Uniform Space–Time Gridding Algorithm for Comparison of Satellite Data Products: Characterization and Sensitivity Study
Authors: Smith Nadia , Menzel W. Paul , Weisz Elisabeth , Heidinger Andrew K. , Baum Bryan A. 
Published: August 2012

AbstractTo overcome the complexities associated with combining or comparing multisensor data, a statistical gridding algorithm is introduced for projecting data from their unique instrument domain to a uniform space–time domain. The algorithm has two components: 1) a spatial gridding phase in which geophysical properties are filtered on the basis of a set of criteria (e.g., time of day or viewing angle) and then aggregated into nearest-neighbor clusters as defined by equal-angle grid cells and 2) a temporal gridding phase in which daily statistics are calculated per grid cell from which longer time-aggregate statistics are derived. The sensitivity of the gridding algorithm is demonstrated using a month (1–31 August 2009) of level 2 Aqua/Moderate Resolution Imaging Spectroradiometer (MODIS) cloud-top pressure (CTP) retrievals as an example. Algorithm sensitivity is tested for grid size, number of days in the definition of a time average, viewing angle, and minimum number of observations per grid cell per day. The average CTP for high-level clouds from a number of different polar-orbiting instruments are compared on a 1° × 1° global grid. With the data projected onto a single grid, differences in CTP retrieval algorithms are highlighted. The authors conclude that this gridding algorithm greatly facilitates the intercomparison of CTP (or any other geophysical parameter) and algorithms in a dynamic environment. Its simplicity lends transparency to understanding the behavior of a given parameter and makes it useful for both research and operational use.
Comparison of PARASOL Observations with Polarized Reflectances Simulated Using Different Ice Habit Mixtures
Authors: Cole Benjamin H. , Yang Ping , Baum Bryan A. , Riedi Jerome , C.-Labonnote Laurent , Thieuleux Francois , Platnick Steven 
Published: August 2012

AbstractInsufficient knowledge of the habit distribution and the degree of surface roughness of ice crystals within ice clouds is a source of uncertainty in the forward light scattering and radiative transfer simulations of ice clouds used in downstream applications. The Moderate Resolution Imaging Spectroradiometer (MODIS) collection-5 ice microphysical model presumes a mixture of various ice crystal shapes with smooth facets, except for the compact aggregate of columns for which a severely rough condition is assumed. When compared with Polarization and Anisotropy of Reflectances for Atmospheric Sciences coupled with Observations from a Lidar (PARASOL) polarized reflection data, simulations of polarized reflectance using smooth particles show a poor fit to the measurements, whereas very rough-faceted particles provide an improved fit to the polarized reflectance. In this study a new microphysical model based on a mixture of nine different ice crystal habits with severely roughened facets is developed. Simulated polarized reflectance using the new ice habit distribution is calculated using a vector adding–doubling radiative transfer model, and the simulations closely agree with the polarized reflectance observed by PARASOL. The new general habit mixture is also tested using a spherical albedo differences analysis, and surface roughening is found to improve the consistency of multiangular observations. These results are consistent with previous studies that have used polarized reflection data. It is suggested that an ice model incorporating an ensemble of different habits with severely roughened surfaces would potentially be an adequate choice for global ice cloud retrievals.
The Relationship between Total Cloud Lightning Behavior and Radar-Derived Thunderstorm Structure
Authors: Metzger Eric , Nuss Wendell A. 
Published: August 2012

Abstract
Total lightning detection systems have been in development since the mid-1980s and deployed in several areas around the world. Previous studies on total lightning found intra- and intercloud lightning (IC) activity tends to fluctuate significantly during the lifetime of thunderstorms and have indicated that lightning jumps or rapid changes in lightning flash rates are closely linked to changes in the vertical integrated liquid (VIL) reading on the National Weather Service’s Weather Surveillance Radar-1988 Doppler (WSR-88D) systems. This study examines the total lightning and its relationship to WSR-88D signatures used operationally to determine thunderstorm severity to highlight the potential benefit of a combined forecast approach. Lightning and thunderstorm data from the Dallas–Fort Worth, Texas, and Tucson, Arizona, areas from 2006 to 2009, were used to relate total lightning behavior and radar interrogation techniques. The results indicate that lightning jumps can be classified into severe wind, hail, or mixed-type jumps based on the behavior of various radar-based parameters. In 25 of 34 hail-type jumps and in 18 of 20 wind-type jumps, a characteristic change in cloud-to-ground (CG) versus IC lightning flash rates occurred prior to the report of severe weather. For hail-type jumps, IC flash rates increased, while CG flash rates were steady or decreased. For wind-type jumps, CG flash rates increased, while IC flash rates either increased (12 of 18) or were steady or decreased (6 of 18). Although not every lightning jump resulted in a severe weather report, the characteristic behavior in flash rates adds information to radar-based approaches for nowcasting the severe weather type.
A Multigrid Wave Forecasting Model: A New Paradigm in Operational Wave Forecasting
Authors: Chawla Arun , Tolman Hendrik L. , Gerald Vera , Spindler Deanna , Spindler Todd , Alves Jose-Henrique G. M. , Cao Degui , Hanson Jeffrey L. , Devaliere Eve-Marie 
Published: August 2012

Abstract
A new operational wave forecasting system has been implemented at the National Centers for Environmental Prediction (NCEP) using the third public release of WAVEWATCH III. The new system uses a mosaic of grids with two-way nesting in a single model. This global system replaces a previous operational wave modeling suite (based on the second release of WAVEWATCH III). The new forecast system consists of nine grids at different resolutions to provide the National Weather Service (NWS) and NCEP centers with model guidance of suitable resolution for all areas where they have the responsibility of providing gridded forecast products. New features introduced in WAVEWATCH III, such as two-way nesting between grids and carving out selected areas of the computational domain, have allowed the operational model to increase spatial resolution and extend the global domain closer to the North Pole, while at the same time optimizing the computational cost. A spectral partitioning algorithm has been implemented to separate individual sea states from the overall spectrum, thus providing additional products for multiple sea states. Field output data are now packed in version 2 of the gridded binary (GRIB2) format and apart from the standard mean wave parameters, they also include parameters of partitioned wave spectra. The partitioning is currently limited to three fields: the wind-wave component, and primary and secondary swells. The modeling system has been validated against data using a multiyear hindcast database as well as archived forecasts. A new software tool developed by the U.S. Army Corps of Engineers (USACE) is used to extend the analysis from overall error estimates to separate skill scores for wind seas and swells.
The 1975–2005 glacier changes in Aosta Valley (Italy) and the relations with climate evolution
Authors: Diolaiuti G.A. , Bocchiola D. , Vagliasindi M. , D’Agata C. , Smiraglia C. 
Published: August 2012

Here three glacier surface area records (years 1975, 1999 and 2005) available for Aosta Valley (western Italian Alps) have been synthesized. The 1975 data have been collected by previous authors who compiled the first Aosta Valley regional glacier database. The 1999 and 2005 surface area data were computed by the authors here combining registered colour orthophotos with differential GPS (DGPS) field measurements. The surface changes of 174 glaciers (those shared within the three records of data) were calculated to describe the recent evolution of a representative subset of Italian glaciers. Aosta Valley glaciers lost 44.3 km2 during 1975–2005, i.e. c. 27% of the initial area. Small glaciers contributed strongly to total area loss, and during 2005 147 glaciers (c. 84.5% of the studied ones) were smaller than 1 km2, covering 20.7 km2 (c. 17% of the total area), but accounted for 43% of the total loss in area (losing 19 km2 from 1975 to 2005). The area change rate accelerated recently (1999–2005: mean area loss of c. 2.8 km2/year; 1975–1999: mean area loss of c. 1.1 km2/year). We then analyse records (1975–2005) of temperature, precipitation and snow cover from three high-altitude (1332 m asl to 3488 m asl) stations within Aosta Valley, to investigate modified climate within the area. We find increasing temperature especially during late spring and summer, and substantially unchanged total precipitation, with marked reduction of snowfall, snow cover, number of snowfall events and duration of continuous snow cover, especially during spring and summer, likely driving shrinking of glacier coverage.
Identification of adequate vehicles to carry nerve regeneration inducers using tubulisation
Authors: do Nascimento-Elias Adriana Helena , Fresnesdas Bruno César , Schiavoni Maria Cristina Lopes , de Almeida Natália Fernanda Gaspar , Santos Ana Paula , de Oliveira Ramos Jean , Junior Wilson Marques , Barreira Amilton Antunes 
Published: August 2012

Abstract

Background
Axonal regeneration depends on many factors, such as the type of injury and repair, age, distance from the cell body and distance of the denervated muscle, loss of surrounding tissue and the type of injured nerve. Experimental models use tubulisation with a silicone tube to research regenerative factors and substances to induce regeneration. Agarose, collagen and DMEM (Dulbecco’s modified Eagle’s medium) can be used as vehicles. In this study, we compared the ability of these vehicles to induce rat sciatic nerve regeneration with the intent of finding the least active or inert substance. The experiment used 47 female Wistar rats, which were divided into four experimental groups (agarose 4%, agarose 0.4%, collagen, DMEM) and one normal control group. The right sciatic nerve was exposed, and an incision was made that created a 10 mm gap between the distal and proximal stumps. A silicone tube was grafted onto each stump, and the tubes were filled with the respective media. After 70 days, the sciatic nerve was removed. We evaluated the formation of a regeneration cable, nerve fibre growth, and the functional viability of the regenerated fibres.

Results
Comparison among the three vehicles showed that 0.4% agarose gels had almost no effect on provoking the regeneration of peripheral nerves and that 4% agarose gels completely prevented fibre growth. The others substances were associated with profuse nerve fibre growth.

Conclusions
In the appropriate concentration, agarose gel may be an important vehicle for testing factors that induce regeneration without interfering with nerve growth.
Higher frequency of cagA EPIYA-C Phosphorylation Sites in H. pylori strains from first-degree relatives of gastric cancer patients
Authors: Queiroz Dulciene MM , Silva Cícero ISM , Goncalves Maria HRB , Braga-Neto Manuel B , Fialho Andréa BC , Fialho André MN , Rocha Gifone A , Rocha Andreia MC , Batista Sérgio A , Guerrant Richard L , Lima Aldo AM , Braga Lucia LBC 
Published: August 2012

Abstract

Background
To evaluate the prevalence of more virulent H. pylori genotypes in relatives of gastric cancer patients and in patients without family histories of gastric cancer.

Methods
We evaluated prospectively the prevalence of the infection by more virulent H. pylori strains in 60 relatives of gastric cancer patients comparing the results with those obtained from 49 patients without family histories of gastric cancer. H. pylori status was determined by the urease test, histology and presence of H. pylori ureA. The cytotoxin associated gene (cagA), the cagA-EPIYA and vacuolating cytotoxin gene (vacA) were typed by PCR and the cagA EPIYA typing was confirmed by sequencing.

Results
The gastric cancer relatives were significant and independently more frequently colonized by H. pylori strains with higher numbers of CagA-EPIYA-C segments (OR = 4.23, 95%CI = 1.53–11.69) and with the most virulent s1m1 vacA genotype (OR = 2.80, 95%CI = 1.04–7.51). Higher numbers of EPIYA-C segments were associated with increased gastric corpus inflammation, foveolar hyperplasia and atrophy. Infection by s1m1 vacA genotype was associated with increased antral and corpus gastritis.

Conclusions
We demonstrated that relatives of gastric cancer patients are more frequently colonized by the most virulent H. pylori cagA and vacA genotypes, which may contribute to increase the risk of gastric cancer.
A randomised controlled trial of a cognitive behavioural intervention for men who have hot flushes following prostate cancer treatment (MANCAN): trial protocol
Authors: Yousaf Omar , Stefanopoulou Evgenia , Grunfeld Elizabeth A , Hunter Myra S 
Published: August 2012

Abstract

Background
This randomised controlled trial (RCT) aims to evaluate the effectiveness of a guided self-help cognitive behavioural intervention to alleviate problematic hot flushes (HF) and night sweats (NS) in men who are undergoing prostate cancer treatment. The trial and the self-help materials have been adapted from a previous RCT, which showed that a cognitive behavioural intervention reduced the self-reported problem-rating of hot flushes in women with menopausal symptoms, and in women undergoing breast cancer treatment. We hypothesize that guided self-help will be more effective than usual care in reducing HF/NS problem-rating at post treatment assessment.

Methods/Design
Seventy men who are undergoing treatment for prostate cancer and who have been experiencing more than ten HF/NS weekly for over a month are recruited into the trial from urology clinics in London. They are randomly allocated to either a four-week self-help cognitive behavioural therapy (CBT) treatment or to their usual care (control group). The treatment includes information and discussion about hot flushes and night sweats in the context of prostate cancer, monitoring and modifying precipitants, relaxation and paced respiration, stress management, cognitive therapy for unhelpful thoughts and beliefs, managing sleep and night sweats, and advice on maintaining these changes.
Prior to randomisation, men attend a clinical interview, undergo 24-48-hour sternal skin conductance monitoring, and complete pre-treatment questionnaires (e.g., problem-rating and frequency of hot flushes and night sweats; quality of life; mood; hot flush beliefs and behaviours). Post-treatment measures (sternal skin conductance and the above questionnaires) are collected four-six weeks later, and again at a six-month follow-up.

Discussion
MANCAN is the first randomised controlled trial of cognitive behavioural therapy for HF/NS for men that measures both self-reported and physiologically indexed symptoms. The results will inform future clinical practice by evaluating an evidence-based, non-medical treatment, which can be delivered by trained health professionals.

Trial registration
UK Clinical Research Network UKCRN10904.
Indocyanine green angiography findings in patients with long-standing Vogt-Koyanagi-Harada disease: a cross-sectional study
Authors: da Silva Felipe T , Hirata Carlos E , Sakata Viviane M , Olivalves Edilberto , Preti Rony , Pimentel Sergio LG , Gomes Andre , Takahashi Walter Y , Costa Rogerio A , Yamamoto Joyce H 
Published: August 2012

Abstract

Background
To investigate indocyanine green angiography (ICGA) findings in patients with long-standing Vogt-Koyanagi-Harada (VKH) disease and their correlation with disease activity on clinical examination as well as with systemic corticosteroid therapy.

Methods
Twenty-eight patients (51 eyes) with long-standing (≥6 months from disease onset) VKH disease whose treatment was tapered based only in clinical features were prospectively included at a single center in Brazil. All patients underwent standardized clinical evaluation, which included fundus photography, fluorescein angiography and ICGA. Clinical disease activity was determined based in the Standardization in Uveitis Nomenclature Working Group. Fisher exact test and logistic regression models were used for statistical analysis.

Results
Disease-related choroidal inflammation on ICGA was observed in 72.5% (31 of 51 eyes). Angiographic findings suggestive of (choroidal and/or retinal) disease activity were not observed on FA. Clinically active disease based on clinical evaluation was observed in 41.2% (21 of 51 eyes). In these 21 eyes, disease-related choroidal inflammation on ICGA was observed in 76.2% (16 of 21 eyes); in the remaining eyes (without clinical active disease) disease-related choroidal inflammation on ICGA was observed in 70.0% (21 of 30 eyes). In respect to systemic corticosteroid therapy, 10 patients (18 of 51 eyes) were under treatment with prednisone. In these 10 (18 of 51 eyes) patients, disease-related choroidal inflammation on ICGA was observed in 83.3% (15 of 18 eyes); in the remaining patients (33 of 51 eyes) disease-related choroidal inflammation on ICGA was observed in 66.7% (22 of 33 eyes).

Conclusion
ICGA findings suggestive of disease-related choroidal inflammation were observed in a considerable proportion of patients with long-standing VKH disease, independent of the inflammatory status of the disease on clinical examination or current use of systemic corticosteroid. Therefore, the current study reinforces the crucial role of ICGA to assist the management and treatment of patients with long-standing VKH disease.
Cardiorespiratory fitness, cardiovascular workload and risk factors among cleaners; a cluster randomized worksite intervention
Authors: Korshøj Mette , Krustrup Peter , Jørgensen Marie Birk , Prescott Eva , Hansen Åse Marie , Kristiansen Jesper , Skotte Jørgen Henrik , Mortensen Ole Steen , Søgaard Karen , Holtermann Andreas 
Published: August 2012

Abstract

Background
Prevalence of cardiovascular risk factors is unevenly distributed among occupational groups. The working environment, as well as lifestyle and socioeconomic status contribute to the disparity and variation in prevalence of these risk factors. High physical work demands have been shown to increase the risk for cardiovascular disease and mortality, contrary to leisure time physical activity. High physical work demands in combination with a low cardiorespiratory fitness infer a high relative workload and an excessive risk for cardiovascular mortality. Therefore, the aim of this study is to examine whether a worksite aerobic exercise intervention will reduce the relative workload and cardiovascular risk factors by an increased cardiorespiratory fitness.

Methods/design
A cluster-randomized controlled trial is performed to evaluate the effect of the worksite aerobic exercise intervention on cardiorespiratory fitness and cardiovascular risk factors among cleaners. Cleaners are eligible if they are employed ≥ 20 hours/week, at one of the enrolled companies. In the randomization, strata are formed according to the manager the participant reports to. The clusters will be balanced on the following criteria: Geographical work location, gender, age and seniority. Cleaners are randomized to either I) a reference group, receiving lectures concerning healthy living, or II) an intervention group, performing worksite aerobic exercise “60 min per week”. Data collection will be conducted at baseline, four months and 12 months after baseline, at the worksite during working hours. The data collection will consist of a questionnaire-based interview, physiological testing of health and capacity-related measures, and objective diurnal measures of heart rate, physical activity and blood pressure. Primary outcome is cardiorespiratory fitness.

Discussion
Information is lacking about whether an improved cardiorespiratory fitness will affect the cardiovascular health, and additionally decrease the objectively measured relative workload, in a population with high physical work demands. Previous intervention studies have lacked robust objective measurements of the relative workload and physical work demands. This study will monitor the relative workload and general physical activity before, during after the intervention, and contribute to the understanding of the previously observed opposing effects on cardiovascular health and mortality from occupational and leisure time physical activity.

Trial registration
The study is registered as ISRCTN86682076.
Genetic signatures shared in embryonic liver development and liver cancer define prognostically relevant subgroups in HCC
Authors: Becker Diana , Sfakianakis Ioannis , Krupp Markus , Staib Frank , Gerhold-Ay Aslihan , Victor Anja , Binder Harald , Blettner Maria , Maass Thorsten , Thorgeirsson Snorri , Galle Peter R , Teufel Andreas 
Published: August 2012

Abstract
Multiple activations of individual genes during embryonic liver and HCC development have repeatedly prompted speculations about conserved embryonic signatures driving cancer development. Recently, the emerging discussion on cancer stem cells and the appreciation that generally tumors may develop from progenitor cells of diverse stages of cellular differentiation has shed increasing light on the overlapping genetic signatures between embryonic liver development and HCC. However there is still a lack of systematic studies investigating this area. We therefore performed a comprehensive analysis of differentially regulated genetic signaling pathways in embryonic and liver cancer development and investigated their biological relevance.
Genetic signaling pathways were investigated on several publically available genome wide microarray experiments on liver development and HCC. Differentially expressed genes were investigated for pathway enrichment or underrepresentation compared to KEGG annotated pathways by Fisher exact evaluation. The comparative analysis of enrichment and under representation of differentially regulated genes in liver development and HCC demonstrated a significant overlap between multiple pathways. Most strikingly we demonstrated a significant overlap not only in pathways expected to be relevant to both conditions such as cell cycle or apoptosis but also metabolic pathways associated with carbohydrate and lipid metabolism. Furthermore, we demonstrated the clinical significance of these findings as unsupervised clustering of HCC patients on the basis of these metabolic pathways displayed significant differences in survival.
These results indicate that liver development and liver cancer share similar alterations in multiple genetic signaling pathways. Several pathways with markedly similar patterns of enrichment or underrepresentation of various regulated genes between liver development and HCC are of prognostic relevance in HCC. In particular, the metabolic pathways were identified as novel prognostically relevant players in HCC development.