bluuebunny/crossref_metadata_2025_split huggingface dataset:
Generalizations of the Jensen-Steffensen and related inequalities
Authors: Bakula Milica , Matić Marko , Pečarić Josip 
Published: October 2009

Abstract
We present a couple of general inequalities related to the Jensen-Steffensen inequality in its discrete and integral form. The Jensen-Steffensen inequality, Slater’s inequality and a generalization of the counterpart to the Jensen-Steffensen inequality are deduced as special cases from these general inequalities.
Statistical approximation properties of q-Baskakov-Kantorovich operators
Authors: Gupta Vijay , Radu Cristina 
Published: October 2009

Abstract
In the present paper we introduce a q-analogue of the Baskakov-Kantorovich operators and investigate their weighted statistical approximation properties. By using a weighted modulus of smoothness, we give some direct estimations for error in case 0 < q < 1.
Soil concentration of selected polycyclic aromatic hydrocarbons around the Petrochemical Plant in Płock in 1987-2006
Authors: Indeka Leonard , Karaczun Zbigniew , Obidoska Grażyna 
Published: October 2009

Soil concentration of selected polycyclic aromatic hydrocarbons around the Petrochemical Plant in Płock in 1987-2006
The Petrochemical Plant Orlen S.A. in Płock was constructed in the 1960s as one of the largest objects of this type in Europe. The facility was unfortunately located among agricultural areas. In the 1990s the plant implemented a number of investments aimed at lowering pollutant loads released to the environment. There is no information, however, whether these investments were successful in decreasing soil pollution with tar substances and polycyclic aromatic hydrocarbons (PAH) and raising the security level for agricultural production within the area. The aim of the research was, therefore, to provide this information. The research was conducted within the agricultural area around the plant. Soil samples were collected in the north-eastern direction from the facility, at five research points at: 1 km, 3 km, 6 km, 12 km and 18 km distances. Concentration of tar substances and PAHs was evaluated and compared with the data from 1987. The results show that PAH emissions from the plant decreased due to the aforementioned environmental investments, which in turn resulted in a significant drop of PAH concentration in soils in around the plant (1-3 km). Nevertheless, their level is still high (especially 1 km away from the refinery) when compared with uncontaminated sites.
The Shuttle Radar Topography Mission Digital Elevation Model as an alternative data source for deriving hydrological characteristics in lowland catchment — Rogożynek catchment case study
Authors: Wasilewski Michał , Chormański Jarosław 
Published: October 2009

The Shuttle Radar Topography Mission Digital Elevation Model as an alternative data source for deriving hydrological characteristics in lowland catchment — Rogożynek catchment case study
This paper describes possibility of supplementing digital topography data needed for hydrologic modeling (WetSpa model) of lowland catchment with existing, freely available DEM data obtained from Shuttle Radar Topography Mission launched on February 11th, 2000. Rogożynek basin (Upper Biebrza) as case study is given. Authors compared three DEMs: topographic — TOPO DEM 20 (20 m resolution), radar — SRTM DEM 90 (90 m res.) and resampled radar — SRTM DEM 20 (20 m res.). There were several characteristics compared and analyzed like: relative height differences, slopes, generated river network and generated subwatersheds (subbasins).
A New Transconjunctival Muscle Reinsertion Technique for Minimally Invasive Strabismus Surgery
Authors: Mojon Daniel S. 
Published: October 2009

Purpose:
To describe a novel, minimally invasive strabismus surgery (MISS) technique for horizontal rectus muscle recessions, plications, and advancements.

Methods:
Subjects for this prospective study were the first 20 consecutive patients who underwent unilateral horizontal rectus muscle surgery with a transconjunctival suturing (TRASU) technique for primary muscle displacements of 4.5 mm or greater or for repeat muscle displacements of 3.0 mm or greater.

Results:

The TRASU technique was associated with no increase in complication rate and was accomplished through a conjunctival approach with an incision that was smaller by 31% ± 11% compared to incisions for previously described MISS approaches. Of the 19 patients (20 eyes) returning for follow-up, 11 (55%) had minimal redness as the only grossly visible sign of surgery on the first postoperative day. By 6 months postoperatively, visual acuity and refractive error were not significantly different from preoperative values (
P
> .10 for each).

Conclusion:
The TRASU technique is safe and can be accomplished through a conjunctival incision that averages two-thirds the size of incisions for previously reported MISS techniques.
The Novel Lipopolysaccharide-Binding Protein CRISPLD2 Is a Critical Serum Protein to Regulate Endotoxin Function
Authors: Wang Zhi-Qin , Xing Wen-Ming , Fan Hua-Hua , Wang Ke-Sheng , Zhang Hai-Kuo , Wang Qin-Wan , Qi Jia , Yang Hong-Meng , Yang Jie , Ren Ya-Na , Cui Shu-Jian , Zhang Xin , Liu Feng , Lin Dao-Hong , Wang Wen-Hui , Hoffmann Michael K. , Han Ze-Guang 
Published: October 2009

Abstract
LPS is an immunostimulatory component of Gram-negative bacteria. Acting on the immune system in a systemic fashion, LPS exposes the body to the hazard of septic shock. In this study we report that cysteine-rich secretory protein LCCL domain containing 2 (CRISPLD2/Crispld2; human and mouse/rat versions, respectively), expressed by multitissues and leukocytes, is a novel LPS-binding protein. As a serum protein, median CRISPLD2 concentrations in health volunteers and umbilical cord blood samples are 607 μg/ml and 290 μg/ml, respectively. Human peripheral blood granulocytes and mononuclear cells including monocytes, NK cells, and T cells spontaneously release CRISPLD2 (range, 0.2–0.9 μg/ml) and enhance CRISPLD2 secretion (range, 1.5–4.2 μg/ml) in response to stimulation of both LPS and humanized anti-human TLR4-IgA Ab in vitro. CRISPLD2 exhibits significant LPS binding affinity similar to that of soluble CD14, prevents LPS binding to target cells, reduces LPS-induced TNF-α and IL-6 production, and protects mice against endotoxin shock. In in vivo experiments, serum Crispld2 concentrations increased in response to a nontoxic dose of LPS and correlated negatively with LPS lethality, suggesting that CRISPLD2 serum concentrations not only are indicators of the degree of a body’s exposure to LPS but also reflect an individual’s LPS sensitivity.
Human Follicular Lymphoma CD39+-Infiltrating T Cells Contribute to Adenosine-Mediated T Cell Hyporesponsiveness
Authors: Hilchey Shannon P. , Kobie James J. , Cochran Mathew R. , Secor-Socha Shelley , Wang Jyh-Chiang E. , Hyrien Ollivier , Burack W. Richard , Mosmann Tim R. , Quataert Sally A. , Bernstein Steven H. 
Published: October 2009

AbstractOur previous work has demonstrated that human follicular lymphoma (FL) infiltrating T cells are anergic, in part due to suppression by regulatory T cells. In this study, we identify pericellular adenosine, interacting with T cell-associated G protein-coupled A2A/B adenosine receptors (AR), as contributing to FL T cell hyporesponsiveness. In a subset of FL patient samples, treatment of lymph node mononuclear cells (LNMC) with specific A2A/B AR antagonists results in an increase in IFN-γ or IL-2 secretion upon anti-CD3/CD28 Ab stimulation, as compared with that seen without inhibitors. In contrast, treatment with an A1 AR antagonist had no effect on cytokine secretion. As the rate limiting step for adenosine generation from pericellular ATP is the ecto-ATPase CD39, we next show that inhibition of CD39 activity using the inhibitor ARL 67156 partially overcomes T cell hyporesponsiveness in a subset of patient samples. Phenotypic characterization of LNMC demonstrates populations of CD39-expressing CD4+ and CD8+ T cells, which are overrepresented in FL as compared with that seen in normal or reactive nodes, or normal peripheral blood. Thirty percent of the FL CD4+CD39+ T cells coexpress CD25high and FOXP3 (consistent with regulatory T cells). Finally, FL or normal LNMC hydrolyze ATP in vitro, in a dose- and time-dependent fashion, with the rate of ATP consumption being associated with the degree of CD39+ T cell infiltration. Together, these results support the finding that the ATP-ectonucleotidase-adenosine system mediates T cell anergy in a human tumor. In addition, these studies suggest that the A2A/B AR as well as CD39 are novel pharmacological targets for augmenting cancer immunotherapy.
Cupressaceae Pollen Grains Modulate Dendritic Cell Response and Exhibit IgE-Inducing Adjuvant Activity In Vivo
Authors: Kamijo Seiji , Takai Toshiro , Kuhara Takatoshi , Tokura Tomoko , Ushio Hiroko , Ota Mikiko , Harada Norihiro , Ogawa Hideoki , Okumura Ko 
Published: October 2009

AbstractPollen is considered a source of not only allergens but also immunomodulatory substances, which could play crucial roles in sensitization and/or the exacerbation of allergies. We investigated how allergenic pollens from different plant species (Japanese cedar and Japanese cypress, which belong to the Cupressaceae family, and birch, ragweed, and grass) modulate murine bone marrow-derived dendritic cell (DC) responses and examined the effect of Cupressaceae pollen in vivo using mice. DCs were stimulated with pollen extracts or grains in the presence or absence of LPS. Cell maturation and cytokine production in DCs were analyzed by flow cytometry, ELISA, and/or quantitative PCR. Pollen extracts suppressed LPS-induced IL-12 production and the effect was greatest for birch and grass. Without LPS, pollen grains induced DC maturation and cytokine production without IL-12 secretion and the response, for which TLR 4 was dispensable, was greatest for the Cupressaceae family. Intranasal administration of Cupressaceae pollen in mice induced an elevation of serum IgE levels and airway eosinophil infiltration. Coadministration of ovalbumin with Cupressaceae pollen grains induced ovalbumin-specific IgE responses associated with eosinophil infiltration. The results suggest that modulation of DC responses by pollen differs among the plant families via (1) the promotion of DC maturation and cytokine production by direct contact and/or (2) the inhibition of IL-12 production by soluble factors. The strong DC stimulatory activity in vitro and IgE-inducing activity in mice support the clinical relevance of Cupressaceae pollen to allergies in humans.
CD36 and TLR Interactions in Inflammation and Phagocytosis: Implications for Malaria
Authors: Erdman Laura K. , Cosio Gabriela , Helmers Andrew J. , Gowda D. Channe , Grinstein Sergio , Kain Kevin C. 
Published: October 2009

Abstract
CD36 participates in macrophage internalization of a variety of particles, and has been implicated in inflammatory responses to many of these ligands. To what extent CD36 cooperates with other receptors in mediating these processes remains unclear. Because CD36 has been shown to cooperate with TLR2, we investigated the roles and interactions of CD36 and TLRs in inflammation and phagocytosis. Using Ab-induced endocytosis of CD36 and phagocytosis of erythrocytes displaying Abs to CD36, we show that selective engagement and internalization of this receptor did not lead to proinflammatory cytokine production by primary human and murine macrophages. In addition, CD36-mediated phagocytosis of Plasmodium falciparum malaria-parasitized erythrocytes (PEs), which contain parasite components that activate TLRs, also failed to induce cytokine secretion from primary macrophages. Furthermore, we demonstrate that CD36-mediated internalization did not require TLR2 or the TLR-signaling molecule IRAK4. However, macrophage pretreatment with TLR agonists markedly stimulated particle uptake via CD36. Similarly, PE uptake was unaffected by TLR deficiency, but in wild-type cells was increased by pretreatment with purified P. falciparum glycosylphosphatidylinositols, which activate TLR2. Our findings indicate that CD36 must cooperate with other receptors such as TLRs to participate in cytokine responses. Although purified P. falciparum components activate TLRs, CD36-mediated internalization of intact PEs is not inflammatory. Further, CD36 mediates internalization of particles, including PEs, independently of TLR signaling, but can functionally cooperate with TLRs to enhance internalization.
Complement Activation by CpG in a Human Whole Blood Loop System: Mechanisms and Immunomodulatory Effects
Authors: Mangsbo Sara M. , Sanchez Javier , Anger Kerstin , Lambris John D. , Ekdahl Kristina Nilsson , Loskog Angelica S. , Nilsson Bo , Tötterman Thomas H. 
Published: October 2009

AbstractPhosphorothioate oligodeoxynucleotides can activate complement, and experimental murine studies have revealed differential effects upon simultaneous TLR stimulation and complement activation compared with either event alone. We set out to investigate the immune stimulatory effects of CpG 2006 in fresh non-anticoagulated human blood with or without presence of active complement. We also sought to elucidate the mechanism behind complement activation upon stimulation with phosphorothioate CpG 2006. In a human blood loop system, both backbone and sequence-specific effects by CpG were counteracted by selective inhibition of C3. Furthermore, DNA backbone-mediated CD40 and CD83 expression on monocytes and sequence-specific IL-6 and TNF production were reduced by complement inhibition. CpG-induced complement activation occurred via either the classical or the alternative pathway and deposits of both IgM and properdin, two activators of complement, were detected on CpG after incubation with EDTA plasma. Quartz crystal microbalance with dissipation monitoring demonstrated alternative pathway convertase build-up onto CpG as a likely pathway to initiate and sustain complement activation. Specific inhibition of C3 suppressed CpG 2006 uptake into monocytes indicating that C3 fragments are involved in CpG internalization. The interplay between complement and TLR9 signaling demonstrated herein warrants further investigation.
Rheology and thermal properties of polypropylene modified by reactive extrusion with dicumyl peroxide and trimethylol propane triacrylate
Authors: Su Feng‐Hua , Huang Han‐Xiong 
Published: October 2009

AbstractTrimethylol propane triacrylate (TMPTA) and dicumyl peroxide (DCP) were used to modify polypropylene (PP) by reactive extrusion in a twin‐screw extruder. The effects of TMPTA concentration on oscillatory shear rheology, melt elongational rheology, and thermal properties were comparatively evaluated. Fourier transform infrared spectroscopy indicated that the grafting reaction took place and TMPTA had been grafted onto the PP backbone. Differential scanning calorimetric results showed that the crystallization temperatures of modified PPs were higher than those of the initial and degraded PPs. The rheological characteristics such as higher storage modulus (G′) at low frequency, increased degree of shear thinning, a plateau in tan δ–ω plot, and upturning at high viscosity in the Cole–Cole plots proved that the long‐chain branches have been added to the linear PP molecule. The melt elongational rheology showed that the modified PPs exhibit improved melt strength and increased elongational viscosity in the presence of TMPTA and DCP, which further confirmed the existence of long‐chain branching (LCB) in their backbone. According to the analytical results from oscillatory shear rheology and elongational rheology, it can be inferred that the LCB level in modified samples increases with an increase in TMPTA concentration. © 2009 Wiley Periodicals, Inc. Adv Polym Techn 28:16–25, 2009; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/adv.20146
Improving the performance of natural gas pipeline networks fuel consumption minimization problems
Authors: Tabkhi F. , Pibouleau L. , Hernandez‐Rodriguez G. , Azzaro‐Pantel C. , Domenech S. 
Published: October 2009

AbstractAs the gas industry has developed, gas pipeline networks have evolved over decades into very complex systems. A typical network today might consist of thousands of pipes, dozens of stations, and many other devices, such as valves and regulators. Inside each station, there can be several groups of compressor units of various vintages that were installed as the capacity of the system expanded. The compressor stations typically consume about 3–5% of the transported gas. It is estimated that the global optimization of operations can save considerably the fuel consumed by the stations. Hence, the problem of minimizing fuel cost is of great importance. Consequently, the objective is to operate a given compressor station or a set of compressor stations so that the total fuel consumption is reduced while maintaining the desired throughput in the line. Two case studies illustrate the proposed methodology. Case 1 was chosen for its simple and small‐size design, developed for the sake of illustration. The implementation of the methodology is thoroughly presented and typical results are analyzed. Case 2 was submitted by the French Company Gaz de France. It is a more complex network containing several loops, supply nodes, and delivery points, referred as a multisupply multidelivery transmission network. The key points of implementation of an optimization framework are presented. The treatment of both case studies provides some guidelines for optimization of the operating performances of pipeline networks, according to the complexity of the involved problems. © 2009 American Institute of Chemical Engineers AIChE J, 2010
Segregated targeting for multiple resource networks using decomposition algorithm
Authors: Bandyopadhyay Santanu , Sahu Gopal Chandra , Foo Dominic Chwan Yee , Tan Raymond R. 
Published: October 2009

AbstractA generalized decomposition technique is presented for determining optimal resource usage in segregated targeting problems with single quality index (e.g., concentration, temperature, etc.) through pinch analysis. The latter problems are concerned with determining minimal resource requirements of process networks characterized by the existence of multiple zones, each consisting of a set of demands and using a unique external resource. However, all the zones share a common set of internal sources. The decomposition algorithm allows the problem to be decomposed into a sequence of subproblems, each of which can in turn be solved using any established graphical or algebraic targeting methodology to determine the minimum requirement of respective resource. This article presents a rigorous mathematical proof of the decomposition algorithm, and then demonstrates its potential applications with case studies on carbon‐constrained energy sector planning, interplant water integration, and emergy‐based multisector fuel allocation. © 2009 American Institute of Chemical Engineers AIChE J, 2010
Kinetic and dynamic study of liquid–liquid extraction of copper in a HFMC: Experimentation, modeling, and simulation
Authors: Younas M. , Druon‐Bocquet S. , Sanchez J. 
Published: October 2009

AbstractIn this work, we present the dispersion‐free liquid–liquid extraction of copper from aqueous streams in a hollow fiber membrane contactor (HFMC). Copper has been transferred from aqueous solutions to heptane using LIX 84‐I (2‐hydroxy‐5‐nonylacetephenone oxime) as extracting agent. In a first step, batch experiments have been performed to identify the extraction kinetics and to measure the partition coefficient of copper aqueous‐organic phase system. Then, the continuous recycled‐base extraction process has been performed in a HFMC Liqui‐Cel® module. The module has been modeled from resistance in series concept to gain the exit concentrations, which are used to develop a dynamic model to calculate the exit concentration of copper from the output of storage tanks. The model has been validated with experimental data at various operating conditions. The integrated process model algorithm was scripted in MATLAB® 7.4 R (a). Simulations have been made for a range of different operating parameters to determine the optimum criterion conditions. © 2009 American Institute of Chemical Engineers AIChE J, 2010
Electrochemical performance and microstructure characterization of nickel yttrium‐stabilized zirconia anode
Authors: Liu Jingbo , Birss Viola , Hill Josephine 
Published: October 2009

AbstractA nickel and yttrium‐stabilized zirconia (Ni‐YSZ) composite is one of the most commonly used anode materials in solid oxide fuel cells (SOFCs). One of the drawbacks of the Ni‐YSZ anode is its susceptibility to deactivation due to the formation of carbonaceous species when hydrocarbons are used as fuel supplies. We therefore initiated an electrochemical study of the influence of methane (CH4) on the performance of Ni‐YSZ anodes by examining the kinetics of the oxidation of CH4 and H2 over operating temperatures of 600–800°C. Anode performance deterioration was then correlated with the degree of carbonization observed on the anode using ex‐situ X‐ray powder diffraction and scanning electron microscopy techniques. Results showed that carbonaceous species led to a significant deactivation of Ni‐YSZ anode toward methane oxidation. © 2009 American Institute of Chemical Engineers AIChE J, 2010
Model predictive control with learning‐type set‐point: Application to artificial pancreatic β‐cell
Authors: Wang Youqing , Zisser Howard , Dassau Eyal , Jovanovič Lois , Doyle Francis J. 
Published: October 2009

AbstractA novel combination of model predictive control (MPC) and iterative learning control (ILC), referred to learning‐type MPC (L‐MPC), is proposed for closed‐loop control in an artificial pancreatic β‐cell. The main motivation for L‐MPC is the repetitive nature of glucose‐meal‐insulin dynamics over a 24‐h period. L‐MPC learns from an individual's lifestyle, inducing the control performance to improve from day to day. The proposed method is first tested on the Adult Average subject presented in the UVa/Padova diabetes simulator. After 20 days, the blood glucose concentrations can be kept within 68–145 mg/dl when the meals are repetitive. L‐MPC can produce superior control performance compared with that achieved under MPC. In addition, L‐MPC is robust to random variations in meal sizes within ±75% of the nominal value or meal timings within ±60 min. Furthermore, the robustness of L‐MPC to subject variability is validated on Adults 1–10 in the UVa/Padova simulator. © 2009 American Institute of Chemical Engineers AIChE J, 2010
Solid–liquid equilibrium of substrates and products of the enzymatic synthesis of ampicillin
Authors: Santana Mônica , Ribeiro Marcelo P. A. , Leite Geisa A. , Giordano Raquel L. C. , Giordano Roberto C. , Mattedi Silvana 
Published: October 2009

AbstractThe solid–liquid equilibrium of precursors and products of the enzymatic synthesis of ampicillin (AMP) [6‐aminopencillanic acid (6‐APA) and D(−)phenylglycine (PG)] was investigated at different temperatures (283–298 K) and pHs (5.5–7.5). Solubility data were obtained using an analytical methodology. Equilibrium dissociation constants were experimentally measured at several temperatures for AMP, 6‐APA, PG, and D(−)phenylglycine methyl ester. A model based on the simplified perturbed hard sphere theory proposed by Khoshkbarchi and Vera (Ind Eng Chem Res. 1996;35:4319‐4327) was fitted against solubility data. The model could describe the water solubility behavior for AMP and PG as function of pH and temperature, but a bias was observed when fitting the model to the solubility of 6‐APA. © 2009 American Institute of Chemical Engineers AIChE J, 2010