bluuebunny/crossref_metadata_2025_split huggingface dataset:
Limited resection followed by intraoperative seed implantation is comparable to stereotactic body radiotherapy for solitary lung cancer
Authors: Parashar Bhupesh , Patel Priti , Monni Stefano , Singh Prabhsimranjot , Sood Nikki , Trichter Samuel , Sabbas Albert , Wernicke A. Gabriella , Nori Dattatreyudu , Chao K. S. Clifford 
Published: July 2010

AbstractBACKGROUND:The objective of this study was to compare the outcomes of patients who underwent wedge resection plus intraoperative brachytherapy versus patients who received stereotactic body radiotherapy (SBRT) for single malignant lung nodules.METHODS:A retrospective chart review included 55 patients who were treated for single lung nodules, and 47 of those patients who had adequate information were chosen for the current analysis. Twenty‐five patients with single malignant lung nodules received SBRT. Twenty‐two patients underwent limited surgical resection plus radioactive seed implantation for solitary malignant lung nodules.RESULTS:Univariate statistical analysis demonstrated a significance difference only for age in the 2 groups: The mean age in the radioactive seed group (66.6 years) was statistically significantly different from the mean of the age in the SBRT group (75.9 years; 2‐sided P = .04). No significant differences were observed between the 2 groups in terms of local control, distant metastasis, survival, or toxicity.CONCLUSIONS:The current results demonstrated comparable efficacy in outcome and toxicity between surgical resection with radioactive seed implantation and SBRT for the treatment of single malignant lung nodules in patients who were not candidates for lobectomy/pneumonectomy. Cancer 2010. © 2010 American Cancer Society.
An access method using fixed backoff for wireless LANs
Authors: Nakamura Kazutoyo , Satake Shinsuke , Inai Hiroshi 
Published: July 2010

AbstractIn a wireless LAN, since two or more terminals randomly access a signal channel, frame collisions might occur. Under the standard IEEE 802.11 protocol, to avoid collisions, each terminal sets a random backoff before frame transmission. Although this measure avoids collisions, it results in useless standby duration and low throughput. To solve that problem, this paper proposes a media access method which has a fixed backoff after a successful transmission. It is shown by simulation that the proposed method reduces frame collisions and improves throughput. Furthermore, our method reduces the frame loss probability and the file transfer delay. 2010 Wiley Periodicals, Inc. Electr Eng Jpn, 173(3): 30–39, 2010; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/eej.21044
Impedimetric Aptasensors Based on Carbon Nanotubes – Poly(methylene blue) Composite
Authors: Porfireva Anna V. , Evtugyn Gennady A. , Ivanov Alexey N. , Hianik Tibor 
Published: July 2010

AbstractThe effect of aptamer structure and immobilization platform on the efficiency of thrombin binding and its detection using electrochemical impedance spectroscopy (EIS) characteristics was investigated with aptasensors based on glassy carbon electrodes covered with multiwalled carbon nanotubes (MWNTs). Aptamers with one or two binding sequences GGTTGGTGTGGTTGG specific for thrombin and poly(dA) and poly(dT) tags able to form dimeric products (aptabodies) were used to establish significance of steric and electrostatic factors in aptasensor performance. We have shown that electropolymerization of methylene blue onto MWNTs significantly improved electrochemical characteristics and sensitivity of thrombin detection against bare MWNTs. Charge transfer resistance and capacitance of the surface layer were measured in the presence of redox probe [Fe(CN)6]3−/4−. Aptasensors make it possible to detect thrombin in the concentration range 1 nM–1 µM with the limit of detection of 0.7 nM (monitoring resistance changes) and 0.5 nM (capacitance changes), respectively.
Differential Pulse Anodic Stripping Voltammetric Simultaneous Determination of Copper(II) and Silver(I) with Bis(2‐hydroxyacetophenone) Butane‐2,3‐dihydrazone Modified Carbon Paste Electrodes
Authors: Gholivand M. B. , Parvin M. H. 
Published: July 2010

AbstractThe behavior of a modified carbon paste electrode (CPE) for simultaneous determination of copper(II) and silver(I) by anodic adsorptive stripping voltammetry (ASV) was studied. The electrode was built incorporating the bis(2‐hydroxyacetophenone) butane‐2,3‐dihydrazone (BHAB) as a complexing agent to a Nujol‐graphite base paste. The resulting electrode demonstrated linear responses over the range of Cu(II) and Ag(I) concentrations 0.1–20 and 0.01–2.0 µM respectively. The relative standard deviation (RSD) for the determination of 5.0 µM of both metal ions were 2.9 and 3.1 % for Cu(II) and Ag(I), respectively. The method has been applied to the analysis of copper in wheat and barley seed samples and silver in developed radiological film.
Voltammetry of Os(VI)‐Modified Polysaccharides
Authors: Trefulka Mojmír , Paleček Emil 
Published: July 2010

AbstractPolysaccharides (PSs), such as dextran, yeast mannan, starch and amylose, were modified with complexes of six‐valent osmium with nitrogen ligands [Os(VI)L] and voltammetric behavior of PS‐Os(VI)L adducts was studied at mercury and carbon electrodes. Using Os(VI)temed as a modification agent and adsorptive transfer stripping (ex situ) method it was possible to determine PSs at submicromolar concentrations directly in the reaction mixture in an excess of monomeric glucose or sucrose both at Hg and carbon electrodes. Conventional (in situ) PS determination in the reaction mixture was possible only with mercury electrodes. The above methods have great potentiality in biological research.
Substantial Influence of Temperature on Anchoring of Gold‐Nanoparticle Monolayer for Performance of DNA Biosensors
Authors: Nowicka Anna M. , Kowalczyk Agata , Donten Mikolaj , Leech Dónal , Hepel Maria , Stojek Zbigniew 
Published: July 2010

AbstractThis paper presents a way of modification of crystalline gold surface with a high quality layer of gold nanoparticles (Au NPs) via self‐assembled dithiol. The application of additional Au NPs monolayer prepared at various temperatures was tested with three types of biosensors previously described in the literature. The examined DNA biosensors differed by the detection method and the way of the immobilization of DNA probe at the modified gold electrode surface. For the immobilization of DNA probe in the sensing layer either the formation of SAM or the affinity binding (biotin – sterptavidin) or covalent attachment were used. The necessary condition of successful preparation of a perfect such monolayer is the preparation temperature of 4 °C. The preparation of Au NPs layers at higher than 4 °C temperatures leads to poor repeatability and unsatisfactory precision of the measurements. The application of the perfect Au monolayer lowers the detection limit (circa by 10 to 100 times) for all tested DNA biosensors.
Sonographic assessment of cervical lymphadenopathy: Role of high‐resolution and color Doppler imaging
Authors: Gupta Abhishek , Rahman Khaliqur , Shahid Mohammad , Kumar Abhishek , Qaseem S. M. Danish , Hassan S. Abrar , Siddiqui Farhan Asif 
Published: July 2010

AbstractBackground.The objective of this article was to study the role of high frequency ultrasound and color Doppler imaging in the diagnostic evaluation of patients with cervical lymphadenopathy.Methods.The present study was carried out over a period of 18 months and included 64 patients of different age groups presenting with cervical lymphadenopathy. Comprehensive sonographic examination of the neck for cervical lymph nodes was performed using the LOGIQ 500 ultrasound machine (GE Wipro Proseries). The scanning was performed with the patient in the supine position, and with the neck hyperextended using a pad or pillow under the shoulders in order to provide optimum exposure of the neck. The parameters considered in this study included: site, mean long axis (L), mean short axis (S), shape index (S/L), echotexture and homogenicity, margins, ancillary features like calcification, necrosis, posterior enhancement, matting and surrounding tissue changes, vascular pattern, and mean arterial resistive index (RI). These findings were correlated with fine‐needle aspiration cytology and excisional biopsy. The nodes were classified as reactive, lymphomatous, and metastatic. The results were subjected to statistical analysis using SPSS software. A p value of <.05 was considered to be significant.Results.The results showed that malignant lymph nodes, especially metastatic nodes, are mostly accompanied with rounded shape, homogenous echotexture, peripheral vascularity, and significantly high RI. Among these sonographic findings, nodal shape (S/L ratio) and RI were more accurate for differentiating benign from malignant lymph nodes. Most of the malignant nodes had well‐defined borders. Calcification, necrosis, posterior enhancement, matting, and hilar flow patterns were characteristically found in tubercular lymphadenitis. A combined ultrasound‐guided and fine‐needle aspiration (FNA) diagnosis had a high sensitivity (95.4%) and specificity (92.3) as compared with situations in which they were used alone.Conclusion.Sonographic findings have a high accuracy in differentiating benign from malignant cervical lymph nodes. An ultrasound scan can be used as the first‐line imaging tool in the diagnostic evaluation of cervical lymphadenopathy, especially in developing countries like India due to its ease, noninvasiveness, reproducibility, and cost effectiveness. It can also be used as an imaging tool for the guided aspirations. However, because of some overlapping in sonographic appearances of benign and malignant nodes, this modality may not have definite diagnostic values. But when combined with FNA, it has a very high sensitivity and specificity. © 2010 Wiley Periodicals, Inc. Head Neck, 2010
Central compartment dissection in laryngeal cancer
Authors: Medina Jesus E. , Ferlito Alfio , Robbins K. Thomas , Silver Carl E. , Rodrigo Juan P. , de Bree Remco , Rinaldo Alessandra , Elsheikh Mohamed N. , Weber Randal S. , Werner Jochen A. 
Published: July 2010

AbstractWe report here a review of the literature intended to clarify the nomenclature and boundaries of the nodes in the “central compartment” of the neck, the frequency with which tumors from the different laryngeal sites metastasize to these nodes, and the indications for central compartment node dissection in the treatment of cancers of the larynx. From this review, we conclude that, until consensus is reached about grouping of the lymph nodes in this area, it is best to refer to these nodes by their anatomic location, ie, prelaryngeal, pretracheal, or paratracheal lymph nodes. It is also advisable to describe dissection of these nodes as selective neck dissection (SND) with an annotation about the specific lymph node groups removed. Metastases in prelaryngeal and paratracheal lymph nodes in patients with squamous cell carcinoma of the larynx are associated with increased tumor recurrence, more frequent metastases in lymph nodes of the lateral compartment of the neck, and decreased survival. If untreated, they may lead to the development of peristomal recurrence. Therefore, elective treatment of level VI nodes is recommended in patients with squamous cell carcinomas of the subglottic region, advanced glottis carcinomas with subglottic extension, and in certain advanced carcinomas of the supraglottic region. © 2010 Wiley Periodicals, Inc. Head Neck, 2011
Prognostic significance of nuclear pSTAT3 in oral cancer
Authors: Macha Muzafar A. , Matta Ajay , Kaur Jatinder , Chauhan S. S. , Thakar Alok , Shukla Nootan K. , Gupta Siddhartha Datta , Ralhan Ranju 
Published: July 2010

AbstractBackgroundAberrant nuclear accumulation of proteins influences tumor development and may predict biologic aggressiveness and disease prognosis. This study determined the prognostic significance of pSTAT3 (phosphorylayed signal transducer and activator of transcription 3) in oral squamous cell carcinomas (OSCCs).Methods and ResultsUsing immunohistochemistry, a significant increase in nuclear accumulation of pSTAT3 was observed in 49 of 90 leukoplakias (54.4%) and 63/94 OSCCs (67%) (ptrend < .001). Increased pSTAT3 was associated with tumor stage (p = .01), nodal metastasis (p = .0018), and tobacco consumption (p = .004). Kaplan–Meier analysis demonstrated that OSCC with increased nuclear pSTAT3 showed significantly reduced disease‐free survival (13 months), compared with the patients with no nuclear pSTAT3 expression (64 months, p = .019). Cox regression analysis revealed nuclear pSTAT3 as the most significant predictor of poor prognosis (p = .024, hazard ratio [HR] = 2.7).ConclusionsIncreased nuclear accumulation of pSTAT3 occurs in early premalignant stages and is a marker for poor prognosis of OSCC. © 2010 Wiley Periodicals, Inc. Head Neck, 2011
Bridging gold: B‐Au‐B three‐center‐two‐electron bonds in electron‐deficient B2Aun−/0 (n = 1, 3, 5) and mixed analogues
Authors: Yao Wen‐Zhi , Li Da‐Zhi , Li Si‐Dian 
Published: July 2010

AbstractA systematic density functional theory and wave function theory investigation on the geometrical and electronic structures of the electron‐deficient diboron aurides B2Au (n = 1, 3, 5) and their mixed analogues B2HmAu (m + n = 3, 5) has been performed in this work. Ab initio theoretical evidences strongly suggest that bridging gold atoms exist in the ground states of C2v B2Au−(1A1), C2 B2Au(1A), C2v B2Au3(2B1), C2v B2Au(1A1), and Cs B2Au5(2A″), which all prove to possess a BAuB three‐center‐two‐electron (3c‐2e) bond. For B2HmAu (m + n = 3, 5) mixed anions, bridging BAuB units appear to be favored in energy over bridging BHB, as demonstrated by the fact that the Au‐bridged C2v B2H2Au− (1A1), Cs B2HAu (1A′), and C1 B2HAu (1A) lie clearly lower than their H‐bridged counterparts Cs B2H2Au− (1A′), C2 B2HAu (1A), and C2v B2HAu (1A1), respectively. Orbital analyses indicate that Au 6s makes about 92–96% contribution to the Au‐based orbitals in these B‐Au‐B 3c‐2e interactions, whereas Au 5d contributes 8–4%. The adiabatic and vertical detachment energies of the concerned anions have been calculated to facilitate their future experimental characterizations. The results obtained in this work establish an interesting 3c‐2e bonding model (BAuB) for electron‐deficient systems in which Au 6s plays a major role with non‐negligible contribution from Au 5d. © 2010 Wiley Periodicals, Inc. J Comput Chem, 2011
Geometrically associative yet electronically dissociative character in the transition state of enzymatic reversible phosphorylation
Authors: Re Suyong , Imai Takashi , Jung Jaewoon , Ten‐No Seiichiro , Sugita Yuji 
Published: July 2010

AbstractReversible phosphorylation of proteins is a post‐translational modification that regulates diverse biological processes. The molecular mechanism underlying phosphoryl transfer catalyzed by enzymes remains a subject of active debate. In particular, the nature of transition state (TS), whether it has an associative or dissociative character, has been one of the most controversial issues. Structural evidence supports associative TS, whereas physical organic studies point to a dissociative character. Here we perform hybrid quantum mechanics/molecular mechanics simulations for the reversible phosphorylation of phosphoserine phosphatase (PSP) to study the nature of the TS. Both phosphorylation and dephosphorylation reactions are investigated based on the two‐dimensional energy surfaces along phosphoryl and proton transfer coordinates. The structures of the active site at TS in both reactions reveal compact geometries, consistent with crystal structures of PSP with phosphate analogues. However, the electron density of the phosphoryl group in both TS structures slightly decreases compared with that in the reactant states. These findings suggest that the TS of PSP has a geometrically associative yet electronically dissociative character and strongly depends on proton transfer being coupled with phosphoryl transfer. Structure and literature database, which searches on phosphotransferases, suggest that such a hybrid TS is consistent with many structures and physical organic studies and likely holds for most enzymes catalyzing phosphoryl transfer. © 2010 Wiley Periodicals, Inc. J Comput Chem, 2011
Heisenberg behavior of some carbon‐beryllium compounds: How well truncated‐CI approaches work
Authors: Calzado Carmen J. , Monari A. , Evangelisti S. 
Published: July 2010

AbstractThis works tries to establish the performance of truncated CI calculations on the evaluation of magnetic coupling parameters with respect to available FCI estimates on a set of carbon‐beryllium clusters. First‐, second‐ and third‐neighbor magnetic coupling constants have been evaluated and many body effective parameters as the cyclic terms. They result from the fitting of the low‐lying states to the eigenvalues of an extended Heisenberg Hamiltonian, involving not only two‐body isotropic terms but also cyclic terms. SDCI and DDCI calculations have been carried out and their performance compared with FCI ones. The impact of the basis set choice and size‐consistency errors have been explored. © 2010 Wiley Periodicals, Inc. J Comput Chem, 2011
Noise analysis for 3‐point chemical shift‐based water‐fat separation with spectral modeling of fat
Authors: Chebrolu Venkata V. , Yu Huanzhou , Pineda Angel R. , McKenzie Charles A. , Brittain Jean H. , Reeder Scott B. 
Published: July 2010

AbstractPurpose:To model the theoretical signal‐to‐noise ratio (SNR) behavior of 3‐point chemical shift‐based water‐fat separation, using spectral modeling of fat, with experimental validation for spin‐echo and gradient‐echo imaging. The echo combination that achieves the best SNR performance for a given spectral model of fat was also investigated.Materials and Methods:Cramér‐Rao bound analysis was used to calculate the best possible SNR performance for a given echo combination. Experimental validation in a fat‐water phantom was performed and compared with theory. In vivo scans were performed to compare fat separation with and with out spectral modeling of fat.Results:Theoretical SNR calculations for methods that include spectral modeling of fat agree closely with experimental SNR measurements. Spectral modeling of fat more accurately separates fat and water signals, with only a slight decrease in the SNR performance of the water‐only image, although with a relatively large decrease in the fat SNR performance.Conclusion:The optimal echo combination that provides the best SNR performance for water using spectral modeling of fat is very similar to previous optimizations that modeled fat as a single peak. Therefore, the optimal echo spacing commonly used for single fat peak models is adequate for most applications that use spectral modeling of fat. J. Magn. Reson. Imaging 2010;32:493–500. © 2010 Wiley‐Liss, Inc.
Edited MRS is sensitive to changes in lactate concentration during inspiratory hypoxia
Authors: Edden Richard A.E. , Harris Ashley D. , Murphy Kevin , Evans C. John , Saxena Neeraj , Hall Judith E. , Bailey Damian M. , Wise Richard G. 
Published: July 2010

AbstractPurpose:To demonstrate the application of Mescher‐Garwood (MEGA) point‐resolved spectroscopy sequence (PRESS) editing to the detection of lactate in the brain at 3T and to investigate changes in lactate concentration associated with inspiratory gas challenges.Materials and Methods:Edited lactate measurements were made in six healthy volunteers while the subjects breathed normoxic (21% O2), hypoxic (12% O2), and hyperoxic (40% O2) gas mixtures. Lactate concentration was quantified relative to the unsuppressed water signal from the same volume.Results:Lactate concentration was elevated in all subjects during hypoxia in a highly significant fashion (mean increase = 39%; P = 0.0003). There was no significant change seen in hyperoxia.Conclusion:MEGA‐PRESS editing at 3T is sufficiently sensitive to detect lactate in the healthy brain with good signal‐to‐noise ratio (SNR), and can be used to investigate changes in cerebral metabolism arising during inspiratory gas challenges. J. Magn. Reson. Imaging 2010;32:320–325. © 2010 Wiley‐Liss, Inc.
Evaluation of group homogeneity during acupuncture stimulation in fMRI studies
Authors: Sun Jinbo , Qin Wei , Dong Minghao , Yuan Kai , Liu Jixin , Liu Peng , Zhang Yi , von Deneen Karen M. , Tian Jie 
Published: July 2010

AbstractPurpose:To evaluate the extent of individual differences of functional MRI (fMRI) signal changes induced by acupuncture stimulation.Materials and Methods:Acupuncture at ST36 and checkerboard stimulation was applied to 16 subjects. We calculated the mean distance using beta values in a generalized linear model (GLM) analysis and employed it to study the group homogeneity by detecting the outliers.Results:A more significant individual difference was presented in acupuncture stimulation compared with visual stimulation through evaluation of the mean distance. From the group results, we found that the activations were more significant in the homogeneous group results. Combining the behavior and fMRI results, there was no direct correlation between deqi index and mean distance in acupuncture stimulation. The deqi index of the outlier was in the normal range and did not differ significantly from others.Conclusion:Traditional group results without removing outliers were not sensitive enough to detect the real acupuncture effect. We suggest that individual difference should be taken into consideration for future acupuncture studies. Also, group analysis paralleled with individual analysis is critical for a full understanding of acupuncture effects. J. Magn. Reson. Imaging 2010;32:298–305. © 2010 Wiley‐Liss, Inc.
Neurovascular changes measured by time‐of‐flight MR angiography in cholesterol‐fed rabbits with cortical amyloid β‐peptide accumulation
Authors: Lemieux Susan K. , Smith‐Bell Carrie A. , Wells Jered R , Ezerioha Nnadozie M. , Carpenter Jeffrey S. , Sparks D. Larry , Schreurs Bernard G. 
Published: July 2010

AbstractPurpose:To test the hypothesis that narrowing of cranial blood vessels in cholesterol‐fed rabbits is a function of the duration of the high cholesterol diet. Such neurovascular changes, caused by elevated serum cholesterol, are linked to stroke and Alzheimer's disease risk.Materials and Methods:Four groups of New Zealand White rabbits were studied. Six were fed a normal diet, 19 were fed a 2% cholesterol diet with 0.12 ppm copper in the drinking water for 8 weeks, 10 weeks, or 12 weeks. Time‐of‐flight (TOF) MR angiography (MRA) at 3 Tesla was used to measure arterial diameters in 11 vessels. Previously published data for amyloid β‐peptide (Aβ) accumulation in the brains measured postmortem were correlated to vessel diameters. Ventricular volumes of rabbits were measured on group‐averaged data.Results:Several vessel diameters decreased with cholesterol diet duration. The posterior communicating arteries showed the largest significant effect. Aβ accumulation was inversely correlated with arterial diameter. Ventricular volumes between the normal diet and 12 weeks cholesterol‐fed groups were not significantly different.Conclusion:Reduction in vessel diameter of medium‐sized vessels but not large vessels was measured in these hypercholesterolemic rabbits. The vessel diameter narrowing and cortical Aβ deposition occurred before measurable ventricular enlargement. J. Magn. Reson. Imaging 2010;32:306–314. © 2010 Wiley‐Liss, Inc.