bluuebunny/crossref_metadata_2025_split huggingface dataset:
Gas Shale: From Nanometer-scale Observations to Well Modeling
Authors: Silin Dmitriy , Kneafsey Timothy J. 
Published: November 2011

Abstract
Our studies of the underlying fundamental gas recovery mechanisms from shale gas are motivated by expectations of increasing role of shale gas in national energy portfolios worldwide. We use pore-scale analysis of reservoir shale samples to identify critical parameters to be employed in a gas flow model used to evaluate well production data. We exploit a number of 3D imaging technologies to study the complexity of shale pore structure: from low-resolution x-ray computed tomography (CT) to focused ion beam and scanning electron microscopy (FIB/SEM). We observe that heterogeneity is present at all scales. The CT data show fractures, thin layers, and density heterogeneity. The nanometer-scale resolution FIB/SEM images show that various mineral inclusions, clays, and organic matter are dispersed within a few-hundred micron-cubed volume. Samples from different regions differ sharply in the shape, size and distribution of pores, solid grains, and the presence of organic matter. Although the samples have clearly distinguishable signatures related to the regions of origin, extremely low permeability is a common feature. This and other pore-scale observations suggest a bounded-stimulated-domain model of a horizontal well within fractured shale that accounts for both compression and adsorption gas storage. Using the method of integral relations, we obtain an exact analytical formula approximating the solution to the pseudo-pressure diffusion equation. This formula makes fast and simple evaluation of well production possible without resorting to complex computations. It defines a decline curve, which predicts two phases of production. During the early stage, the production rate declines with reciprocal square root of time, whereas later the rate declines exponentially. The model has been verified by successful matching monthly production data from a number of shale gas wells collected over several years of operation. With appropriate scaling, the data from multiple wells collapse on a single type curve. Pore-scale image analysis and the mesoscale model suggest a dimensionless adsorption storage factor (ASF) to characterize the relative contributions of compression and adsorption gas storage.
Auditor Quality and Loan Syndicate Structure
Authors: Kim Jeong-Bon , Song Byron Y. 
Published: November 2011

SUMMARY
This study investigates whether and how the quality of external auditors hired by borrowers has an impact on loan syndicate structure. Our empirical analyses, using a sample of U.S. syndicated loans from 1996 to 2009, show the following findings: First, a larger number of banks participate in syndicated loans to borrowing firms with Big 4 (or previously Big 5 or Big 6) auditors than to those with non-Big 4 auditors. Second, the percentage of a syndicated loan retained by the lead bank(s) is smaller when the borrower is a client of a Big 4 auditor than when the borrower is a client of a non-Big 4 auditor. Third, the effect of auditor quality (Big 4 versus non-Big 4) on loan ownership structure is less pronounced when lenders are able to gather more information about the borrower prior to the loan deal. Overall, our results suggest that auditor quality plays an important role in loan syndication by alleviating information asymmetries between lead banks and non-lead participant banks.
JEL Classifications: G21; G32; M42.
Data Availability: Data are publicly available from sources identified in the paper.
The Impact on Auditor Judgments of CEO Influence on Audit Committee Independence
Authors: Cohen Jeffrey R. , Gaynor Lisa Milici , Krishnamoorthy Ganesh , Wright Arnold M. 
Published: November 2011

SUMMARY
Despite the importance of audit committee independence in ensuring the integrity of the financial reporting process, recent research suggests that even when audit committees meet regulatory independence requirements, certain factors, such as undue influence by the CEO over the selection of the audit committee, may diminish the ability of its members to be substantively independent. This study investigates whether auditors consider CEO influence over audit committee independence when making audit judgments where management's incentives to manage earnings differ. In an experiment, we find that audit partners and managers waive a larger amount of a proposed audit adjustment when management's incentives for earnings management are low than when incentives are high. However, when management incentives are high, auditors are less likely to waive as much of an adjustment when the CEO has less influence over the audit committee's independence than when the CEO's influence is greater. In all, the results support our expectations that auditors consider CEO influence on audit committee independence in the resolution of contentious accounting issues.
Data Availability: Contact the authors.
Health Information Exchange and Care Coordination of Diabetic Patients Between Medicine and Dentistry
Authors: Hummel Jeffrey , Gandara Beatrice K 
Published: November 2011

In Brief
Inadequate coordination of care between dentists and medical doctors presents a barrier to comprehensive management of patients with diabetes. New technologies for managing and exchanging health data hold a promise of improved transfer of clinical information between specialties. The authors present a model of how information technology can be used to support standardized workflows in medicine and dentistry to optimize care coordination for patients with diabetes.
Gwyddion: an open-source software for SPM data analysis
Authors: Nečas David , Klapetek Petr 
Published: November 2011

Abstract
In this article, we review special features of Gwyddion—a modular, multiplatform, open-source software for scanning probe microscopy data processing, which is available at http://gwyddion.net/. We describe its architecture with emphasis on modularity and easy integration of the provided algorithms into other software. Special functionalities, such as data processing from non-rectangular areas, grain and particle analysis, and metrology support are discussed as well. It is shown that on the basis of open-source software development, a fully functional software package can be created that covers the needs of a large part of the scanning probe microscopy user community.
Proposed Severity and Response Criteria for Routine Assessment of Patient Index Data (RAPID3): Results for Categories of Disease Activity and Response Criteria in Abatacept Clinical Trials
Authors: PINCUS THEODORE , HINES PATRICIA , BERGMAN MARTIN J. , YAZICI YUSUF , ROSENBLATT LISA C. , MacLEAN ROSS 
Published: November 2011

Background.An index is needed to assess the status of patients with rheumatoid arthritis (RA), as none of the existing measures are applicable to all individual patients. The 28-joint Disease Activity Score (DAS28) is the most specific and widely used index. Routine Assessment of Patient Index Data (RAPID3) is an index containing only the 3 patient self-report core dataset measures, without a laboratory test or formal joint count, and with simple scoring. RAPID3 is correlated significantly with DAS28, but calculated in 5–10 seconds on a Multidimensional Health Assessment Questionnaire (MDHAQ), compared to 114 seconds for DAS28.Methods.DAS28 (0–10 scale) categories for high, moderate, and low activity, and remission (≤ 2.6, 2.6–3.2, 3.21–5.1, and > 5.1, respectively) and proposed RAPID3 (0–30 scale) categories for severity (0 ≤ 3, 3.1–6, 6.1–12, and > 12) were compared in patients taking abatacept and control-treated patients at the endpoint of the Abatacept in Inadequate Response to Methotrexate (AIM) and the Abatacept Trial in Treatment of Anti-TNF INadequate Responders (ATTAIN) clinical trials, using cross-tabulations and kappa statistics.Results.Overall, 92%–99% of patients classified as having high DAS28 activity had high or moderate RAPID3 severity, while 64%–83% in DAS28 remission had RAPID3 low severity or remission; 50%–82% of patients with good or poor EULAR responses had good or poor RAPID3 responses. Kappa values ranged from 0.25 to 0.48, and weighted kappas from 0.32 to 0.52, indicating fair to moderate agreement for the 2 indices.Conclusion.Proposed RAPID3 severity and response categories yield comparable results to DAS28 and EULAR criteria in AIM and ATTAIN. DAS28 is more specific for clinical trials. RAPID3 does not preclude also scoring DAS28, and may be informative in the infrastructure of routine care.
Agirs à risque à l'adolescence
Authors: Gianèse-Madelaine Catherine , Pavoux Max 
Published: November 2011

Résumé « Agirs à risques à l’adolescence ; de la rupture à la séparation. » À l’adolescence, certaines modalités d’expression de la souffrance psychique apparaissent sous la forme « d’agirs » à risque. Elles peuvent être pensées comme des tentatives inconscientes de figuration et de ré-affiliation, dans ce moment propice où les liens à la famille et à l’environnement se réaménagent. L’écoute psychanalytique de la famille peut offrir un accueil et un contenant qui visent à transformer la brutalité des éprouvés mobilisés à travers ces agirs et à soutenir l’avènement de processus intersubjectifs transitionnels. Cependant, une première étape, fondée sur les qualités de contenance du cadre, est fondamentale.
L'autorité familiale entre crise et conflit
Authors: Chapellon Sébastien 
Published: November 2011

Résumé « L’autorité familiale entre crise et conflit. » La confrontation à l’autorité, plus que d’être garante de l’interdit, permet à l’enfant d’échafauder un jeu dans lequel la désobéissance questionne les places générationnelles. L’identification aux adultes ne se suffit pas de tendresse, elle suit un processus conflictuel qui dépend du cadre formé par la société. Celle-ci doit, dès la phase anale, permettre à la famille d’amorcer un « conflit fondamental ». Ce processus, qui est celui de l’identification au surmoi parental, fait de l’autorité un moyen de transmission essentiel : non seulement en ce qui concerne les normes et codes culturels, mais aussi, et peut-être surtout, celui d’une contenance psychique.
Lipoprotein(a) as a potential marker of residual liver function in hepatocellular carcinoma
Authors: Uccello Mario , Malaguarnera Giulia , Pelligra Elisa M , Biondi Antonio , Basile Francesco , Motta Massimo 
Published: November 2011

AbstractThe residual liver function is a major clinical index in hepatocellular carcinoma (HCC) patients. As the liver plays a crucial role in lipid and lipoprotein metabolism, the significant impairment of the hepatic function occurring during chronic liver diseases, such as HCC, can influence plasma lipoprotein profiles. Although, lipoprotein(a) (Lp(a)) circulating concentrations are mostly determined by genetic factors, in the majority of reports they have shown a correlation with the hepatic status and a significant decrease in HCC and liver cirrhosis patients than among the controls. In such a way, Lp(a) may represent a new additional and useful marker for a more complete assessment and monitoring of the liver function in patients with HCC and liver cirrhosis. Further studies are needed in order to evaluate the clinical significance of Lp(a) in HCC.
Sequential therapy (triple drug-based induction chemotherapy followed by concurrent chemoradiotherapy) in locally advanced inoperable head and neck cancer patients - Single institute experience
Authors: Somani Naresh , Goyal S , Pasricha R , Khuteta N , Agarwal P , Garg A K , Singhal H 
Published: November 2011

Abstract
Context: India has a high incidence of head and neck squamous cell carcinoma (HNSCC) mostly presenting in advanced stage. In the majority of inoperable patients a combination of chemotherapy and radiotherapy (CRT) is considered as the treatment of choice. Adding induction chemotherapy (ICT) before CRT has shown to decrease systemic relapse. Incorporation of taxanes to the cisplatin and 5-FU-based ICT has shown increase in response rates. Aims: To evaluate the efficacy and toxicity of triple drug-based ICT followed by CCRT in locally advanced, inoperable HNSCC in the Indian context. Settings and Design: Prospective, non-controlled, observational study, a single-institute experience. Materials and Methods: Consecutive, locally advanced inoperable HNSCC patients were put on sequential therapy consisting of docetaxel, 5-FU and cisplatin for three cycles followed by concurrent weekly cisplatin and radiotherapy for responding or stable disease patients. Results: Forty-four patients were enrolled with male,female ratio of 33/44(75%) and 11/44(25%). Hypopharynx 16/44(36.36%) was the most common site followed by oral cavity 12/44(27.27%) and oropharynx 12/44(27.27%); 38/44(86.36%) patients could complete the planned treatment. Seven patients required dose reduction in ICT. As per the RECIST criteria, 16 patients had Complete Response (CR) and 15 had partial response (PR), 10 had stable disease (SD) and three had progressive disease (PD) after ICT. Thirty-eight patients received concomitant chemo radiotherapy (CCRT); 28/44 (66.63%) patients achieved CR, 10/44 (22.72 %) had PR. The main toxicity was mucositis 18/44 (40.90%) secondary to ICT. Grade III and IV hematological toxicity was seen in 16/44(36.36%), of which 6/44 (13.63%) had febrile neutropenia. Conclusions: Triple drug-based sequential therapy is tolerable in our context. In this trial from a single institute the results are very encouraging.
An uneventful pregnancy and delivery, in a case with chronic myeloid leukemia on imatinib
Authors: Martin Jovita , Ramesh Anita , Devadasan Lalitha , Martin Jude J ,   Palaniappan
Published: November 2011

AbstractThe concomitant occurrence of pregnancy and chronic myelogenous leukemia is uncommon. We describe the successful management of a 24-year-old woman in the first trimester of her pregnancy with chronic myelogenous leukemia (CML) in the chronic phase, who was on treatment with imatinib, which was stopped by 10 th week of pregnancy. Until, she completed full term of pregnancy she was on hydroxyurea. The use of imatinib did not have adverse effects on the fetus. The patient had a normal vaginal delivery and gave birth to a healthy 2500 g girl at 37 weeks of gestation. We conclude that imatinib in the first trimester of pregnant lady with CML, though has particular concern regarding the potential teratogenic and other adverse effects, has shown evidences of safe conception, pregnancy and delivery in ladies with CML.
Using real-time alerts for clinical trials
Authors: Chow E. , Zuberi M. , Seto R. , Hota S. , Fish E.N. , Morra D. 
Published: November 2011

SummaryBackground: Clinical trials are widely accepted as a necessary step in evaluating the safety and efficacy of new pharmaceutical products. In order for a sufficiently powered study, a clinical trial depends on the effective and unbiased recruitment of eligible patients. Trials involving seasonal diseases like influenza pose additional challenges.Objective: This is a feasibility study of a mobile real-time alerting system to systematically identify potential study subjects for a randomized controlled trial evaluating the safety and efficacy of early intervention with interferon alfacon-1 for patients hospitalized for influenza virus infection. Methods: The alerting system was setup in a 471-bed acute care teaching hospital, enabled with computerized physician order entry (CPOE) and a rules-based alerting system. Patients were identified from the entire hospital using two alerts types: pharmacy prescription records for antiviral drugs, and positive influenza laboratory results. Email alerts were generated and sent to BlackBerry® devices carried by the study personnel for a 6 month period. The alerts were archived automatically on a secure server and were exported for analysis in Microsoft Access.Results: Over a period of 21 weeks, 779 total alerts were received. The study team was alerted to 241 patients, of whom 85 were potential study subjects. The alert system identified all but one of the patients independently identified by infection control.Conclusions: Real-time identification of potential study subjects is possible with the integration of computerized physician order entry and BlackBerry® technology. It is a viable method for the systematic identification of patients throughout a hospital, particularly for trials investigating time-sensitive disease progression.
Kanosa- Lending an Ear to the Body and Mind Secrets of Rural Women:Thoughts on Health and Modernity
Authors: Dighe Satlaj 
Published: November 2011

This review article discusses the text Kanosa - Grameen Streechya Sharir ani Manatil Gupitancha, translated as ‘Lending an Ear to the Secrets of Body and Mind of the Rural Woman’ by Dr. Rani Bang. The original text provides detailed information on various life-cycle health experiences of women; illness categories (nosography); health practices; sexualities; diets and local life-worlds of health and bodily experiences based on the in depth discussions with local women. In the context of current trends and prevailing ideologies in the community health sector of India, our critical review highlights the significance of the approach adopted by Dr. Rani Bang in locating health as an integral part of culture.We seek to introduce important discussions in Bang’s text on ethnophysiology, local categories of diseases and their implications on modern community health interventions, as ell as the definitions of the normal, abnormal and pathological as provided by the local community. In light of these discussions, we examine certain characteristics of the modern Indian community health sector such as its inability to work with local epistemologies of health and illness and its philosophical reliance on Cartesian dualism and western notions of personhood. Certain features of community health such as complete separation of fertility and sexuality as well as the exclusively nutritional approach to dietary phenomena are also reviewed with reference to Kanosa and other significant literature.
Perinatal mortality in Indonesia: an unfinished agenda
Authors: Jahja Riawati 
Published: November 2011

Perinatal mortality is a profound issue in maternal and child health due to its close relation with the maternal condition. There exist Millennium Development Goals (MDGs) which are to be achieved by 2015. These are coupled with a continuing need for comprehensively monitoring and identifying factors associated with perinatal mortality, which is a primary concern for developing countries inclusive of Indonesia. Previous and on-going health programs could have brought about strategic interventions but as different attributes can emerge due to epidemiological transition, and given the fact that associated factors may remain persistent, forward thinking strategies in public health are forever in need of renewal. Results from our research show that educational variables, poor awareness towards proper antenatal care visits and weak services at the front-line of healthcare delivery (community outreach) worsen the condition of childbearing women, raising the question of biological risk factors in line with socio-economic variables.
Characterization and Some Properties of Poly(vinyl chloride)/Sepiolite Nanocomposites
Authors: Turhan Yasemin , Doǧan Mehmet , Alkan Mahir 
Published: November 2011

AbstractPoly(vinyl chloride) (PVC)/sepiolite nanocomposites were prepared using PVC and natural, organo‐modified, acid–activated, and calcined sepiolite samples through the solution intercalation method. Thermogravimetric (TG) analysis, UV–vis spectrophotometry, Fourier transform infrared spectroscopy, and scanning electron microscopy were used to determine the thermal stability, optical behavior, interactions, and morphology of samples, respectively. The dispersion of sepiolite in the PVC matrix was examined by X‐ray diffraction (XRD) and transmission electron microscopy (TEM). The nanocomposites exhibited higher thermal stability than that of pure PVC. XRD and TEM results showed that sepiolite particles were dispersed in the nanoscaled PVC matrix. The UV–vis spectra showed that the transmission of nanocomposites increased with the sepiolite content and wavelength. The thermal degradation behavior of PVC was investigated by using TG analysis under nonisothermal conditions at different heating rates under a nitrogen atmosphere. The apparent activation energy of samples was determined by using the Kissinger method. The nanocomposite showed higher activation energy than that of pure PVC. The results showed that the thermal degradation of PVC was shifted toward higher temperatures with an increase in the amount of sepiolite. © 2011 Wiley Periodicals, Inc. Adv Polym Techn 32: E65–E82, 2013; View this article online at wileyonlinelibrary.com. DOI 10.1002/adv.20271
A basis for updating our approach to resistant acute leukemia
Authors: Cunningham Isabel 
Published: November 2011

AbstractNo studies exist documenting that chemotherapy alone eradicates tumors composed of leukemic cells in a large group of patients with tumors at any one site. Yet, its use has continued over 40 years in the absence of data. Consensus protocols exist only for testis and meningeal tumors, relying on local therapy. To constitute a body of knowledge about tumors at one site, the breast was chosen and all published cases were analyzed, with follow‐up obtained, to document the behavior of acute leukemia tumors and survival after presentation. Among 235 cases (52% published since 2000), overall survival was poor, particularly for the 43% with concurrent morphologic marrow relapse, with 66‐73% one‐year mortality. Only 4 of 106 patients treated with chemotherapy alone survived 4 years. The majority of AML and ALL tumors were only transiently responsive to anti‐leukemia treatments, including transplant, and next relapses were as, or more, common in further tumors than in marrow. A pattern of tumors similar to the metastases of invasive lobular breast cancer was revealed. When relapse occurred in marrow, durable remission was only rarely obtained. These data suggest a potential benefit of incorporating extent of disease workup at diagnosis and relapse into prospective trials. This could yield an accurate incidence of extramedullary tumors and a means to identify occult residual disease which could lead to marrow relapse. This approach could potentially result in greater success in curing acute leukemias. Am. J. Hematol. 2012. © 2011 Wiley Periodicals, Inc.
Citation characterization and impact normalization in bioinformatics journals
Authors: Huang Hong , Andrews James , Tang Jiang 
Published: November 2011

AbstractBioinformatics journals publish research findings of intellectual synergies among subfields such as biology, mathematics, and computer science. The objective of this study is to characterize the citation patterns in bioinformatics journals and their correspondent knowledge subfields. Our study analyzed bibliometric data (impact factor, cited‐half‐life, and references‐per‐article) of bioinformatics journals and their related subfields collected from the Journal Citation Reports (JCR). The findings showed that bioinformatics journals' citations are field‐dependent, with scattered patterns in article life span and citing propensity. Bioinformatics journals originally derived from biology‐related subfields have shorter article life spans, more citing on average, and higher impact factors. Those journals, derived from mathematics and statistics, demonstrate converse citation patterns. Journal impact factors were normalized, taking into account the impacts of article life spans and citing propensity. A comparison of these normalized factors to JCR journal impact factors showed rearrangements in the ranking orders of a number of individual journals, but a high overall correlation with JCR impact factors.