bluuebunny/crossref_metadata_2025_split huggingface dataset:
Monitoring of Anti Cancer Drug Letrozole by Fast Fourier Transform Continuous Cyclic Voltammetry at Gold Microelectrode
Authors: Norouzi Parviz , Ganjali Mohammad Reza , Qomi Mahnaz , Nemati Kharat Ali , Zamani Hassan Ali 
Published: August 2010

AbstractA continuous cyclic voltammetric study of letrozole at gold microelectrode was carried out. The drug in phosphate buffer (pH 2.0) is adsorbed at −200 mV, giving rise to change in the current of well‐defined oxidation peak of gold in the flow injection system. The proposed detection method has some of advantages, the greatest of which are as follows: first, it is no more necessary to remove oxygen from the analyte solution and second, this is a very fast and appropriate technique for determination of the drug compound in a wide variety of chromatographic analysis methods. Signal‐to‐noise ratio has significantly increased by application of discrete Fast Fourier Transform (FFT) method, background subtraction and two‐dimensional integration of the electrode response over a selected potential range and time window. Also in this work some parameters such as sweep rate, eluent pH, and accumulation time and potential were optimized. The linear concentration range was of 1.0×10−7−1.0×10−10 mol/L (r=0.9975) with a limit of detection and quantitation 0.08 nmol/L and 0.15 nmol/L, respectively. The method has the requisite accuracy, sensitivity, precision and selectivity to assay letrozol in tablets. The influences of pH of eluent, accumulation potential, sweep rate, and accumulation time on the determination of the letrozol were considered.
Highly Selective Potentiometric Oxalate Ion Sensors Based on Ni(II) Bis‐(m‐aminoacetophenone)ethylenediamine
Authors: Rawat Aruna , Chandra Sulekh , Sarkar Anjana 
Published: August 2010

AbstractA plasticized PVC (polyvinyl chloride) membrane based oxalate ion selective electrode has been developed by using the condensation product of m‐aminoacetophenone and ethylenediamine. The transition metal complexes of the ligand N,N′‐bis(m‐aminoacetophenene)ethylenediamine (L) were synthesized and incorporated as ionophore for the synthesis of oxalate ion selective electrodes. Most appropriate result in terms of dynamic range, detection limit and response behavior was determined for the Ni(II) bis‐(m‐aminoacetophenone)ethylenediamine complex. The electrode demonstrated higher selectivity for oxalate ion with improved performance as compared to other carriers reported in past. The electrode shows Nernstian slope of (−28.5±0.4) mV·decade−1 with improved linear range of 1×10−1−1×10−7 mol·L−1, with a comparatively lower detection limit in the pH range of 5–10.5, giving a relatively fast response within 10 s and reasonable reproducibility. The selectivity coefficient was calculated using matched potential method and fixed interference method. The lifetime of the electrode was found to be nearly 2 months. The response mechanism and the interaction of oxalate ion with the complexes have been discussed by UV‐visible spectroscopic technique. Further the electrode was also successfully applied to determine the oxalate content in water samples.
Nanoporous Lanthanum Tungstate: A Viable Adsorbent for Heavy Metals and Organic Pollutants
Authors: Anbia Mansoor , Ashrafizadeh Seyed Nezameddin 
Published: August 2010

AbstractRemoval of heavy metal cations from synthetic and industrial electroplating effluents by means of mesoporous lanthanum tungstate sorbents was thoroughly investigated. Three types of such sorbents, namely I‐LT, II‐LT and III‐LT, uncalcined and calcined, were produced and characterized by means of X‐ray diffraction, nitrogen sorption isotherms and thermogravimetry analysis (TGA). Results of the experiments for chromium, copper, mercury, iron and lead removal from both synthetic and real industrial wastewater solutions, using these novel sorbents, exhibit promising. Details of this new approach towards wastewater treatment have been discussed and the potentials of technological advancement using mesoporous lanthanum tungstate for environmental purposes addressed. Comparison with the literature shows superiority of the produced adsorbents over reported products.
Sorption Mechanism of Cadmium from Aqueous Solution on Iron Sulphide
Authors: Mustafa S. , Misbahud D. , Sammad Y. H. , Zaman M. I. , Sadullah K. 
Published: August 2010

AbstractThe characterization and adsorption studies of Cd2+ on FeS were performed. Adsorption of Cd2+ from aqueous solutions on synthetic iron sulphide (FeS) was investigated as a function of pH (5–7) and temperature (303–323 K). It was found that the iron sulphide (FeS) had adsorptive properties comparable with those of other adsorbents reported in the literature. The sorption of Cd2+ was observed to increase with the increase in pH but not strongly sensitive to temperature. The adsorption data fitted both the Kurbatov and Langmuir adsorption models. In addition, ΔG⊖ values were calculated from the values of the binding constant, which showed that the cadmium adsorption process was spontaneous in nature.
Study on the Interaction between a Novel Ionic Liquid Probe and Anionic Surfactants Using Resonance Light Scattering Spectra and Its Analytical Application
Authors: Wang Weijuan , Zeng Yanbo , Lu Qiying , Xiao Ying , Li Lei , Ye Zhaoxia , Pang Ming 
Published: August 2010

AbstractThe interaction between anionic surfactants (AS) and 1‐hexadecyl‐3‐methylimidazolium bromide [C16mim]Br was studied by using resonance light scattering (RLS) technique, UV‐Vis spectrophotometry and fluorometric methods. In Britton Robinson (BR) buffer (pH 6.0), [C16mim]Br reacted with AS to form supermolecular complex which resulted in enhancement in RLS intensity. Their maximum RLS wavelengths were all at 390 nm. Some important interacting experimental variables, such as the solution acidity, [C16mim]Br concentration, salt effect and addition order of the reagents, were investigated and optimized. Under the optimum conditions, quantitative determination ranges were 0.001–7 μg·mL−1 for dodecyl sodium sulfate (SDS), 0.001–6 μg·mL−1 for sodium dodecylbenzene sulfonate (SDBS) and 0.005–7 μg·mL−1 for sodium lauryl sulfonate (SLS), respectively, while the detection limits were 1.3 ng·mL−1 for SDS, 1.0 ng·mL−1 for SDBS and 5.1 ng·mL−1 for SLS, respectively. Based on the ion‐association reaction, a highly sensitive, simple and rapid method has been established for the determination of AS.
Catalytic and Efficient Oxidation of Urazole Derivatives to Their Corresponding Triazolinediones Using Ammonium Nitrate and Metal Hydrogen Sulfate as Catalyst
Authors: Ghorbani‐Choghamarani Arash , Zeinivand Javad , Mallakpour Shadpour 
Published: August 2010

AbstractCatalytic oxidation of a variety of urazoles to the triazolinediones via combination of NH4NO3 in the presence of a catalytic amount of aluminium hydrogen sulfate has been developed at room temperature in dichloromethane.
Configuration‐Specific Reaction of Nitric Oxide with Aldehyde Arylhydrazones
Authors: Yang Desuo , Zhu Haiyun , Guo Yaning , Wu Longmin 
Published: August 2010

AbstractReactions of aldehyde arylhydrazones (1) with nitric oxide in the presence of trace oxygen gave exclusively (E)‐C(1′)‐nitrohydrazones (2) in high yield. The structure of products was confirmed by NMR, IR, MS and X‐ray crystallography. The reaction is assumed to be initiated by addition of NO2 to the imine double.
Synthesis and Bioactivity of Novel N,N′‐Diacylhydrazine Derivatives Containing Furan (II)
Authors: Li Xichen , Yang Xinling , Cui Zining , Li Ying , He Hongwu , Ling Yun 
Published: August 2010

AbstractDiacylhydrazines have been found as molting hormone analogs since RH‐5849 was reported as the first nonsteroidal ecdysone agonist in 1988. Optimizations on diacylhydrizines with benzoheterocycle containing oxygen were widely explored in recent years. In order to find novel compounds with high bioactivity, a series of mono‐ (I) and di‐acylhydrazine (II) derivatives containing furan were designed and synthesized. Their structures were confirmed by 1H NMR, IR, elemental analyses and single crystal X‐ray diffraction analyses (II7). The bioassay results showed that some of the mono‐acylhydrazine (I) derivatives exhibited good larvicidal activity against Culex pipiens pallens at 10 mg/L and better than those of di‐acylhydrazines (II). Generally, the anti‐tumor activity of di‐acylhydrazines (II) was better than that of mono‐acylhydrazines (I).
22‐Oxa‐1,25‐dihydroxyvitamin D3 efficiently inhibits tumor growth in inoculated mice and primary histoculutre of cholangiocarcinoma
Authors: Seubwai Wunchana , Wongkham Chaisiri , Puapairoj Anucha , Okada Seiji , Wongkham Sopit 
Published: August 2010

AbstractBACKGROUND:It is well known that 1α,25‐Dihydroxyvitamin D3(1,25[OH]2D3) restrains cell proliferation and induces differentiation and apoptosis in normal and tumor cells. The authors of this report recently demonstrated that 1,25(OH)2D3 effectively inhibits the proliferation of cholangiocarcinoma (CCA) cell lines. The antitumor activity and the underlying mechanism of 22‐oxa‐D3, an analog of vitamin D, in mice and in tissue cultures from patients with CCA were further explored in the current study.METHODS:Cell growth and cell cycle distribution were examined in CCA cells by 3‐(4,5‐dimethylthiazol‐2‐yl)‐2,5‐diphenyltetrazolium bromide (MTT) assay and flow cytometry. Mice were injected subcutaneously with 4 × 106 CCA cells at both flank sides and intraperitoneal injections with phosphate‐buffered saline or 22‐oxa‐D3(15 μg/kg/day) for 17 days thereafter. Tumors were removed the next day. The expression levels of cyclin D1 and the cyclin‐dependent kinase inhibitor p21 were determined by Western blot analysis and immunohistochemistry. Growth inhibition of 22‐oxa‐D3 in fresh tissue samples from patients with CCA was analyzed by using a histodrug response assay.RESULTS:22‐Oxa‐D3 effectively suppressed the growth of CCA cell lines in a time‐dependent and dose‐dependent manner. 22‐Oxa‐D3 arrested CCA cells at G1 phase to S phase by the suppression of cyclin D1 expression and the up‐regulation of p21. Supplementation of 22‐oxa‐D3 to CCA‐inoculated mice significantly inhibited tumor growth without hypercalcemia or serious side effects. The treatment also induced cellular apoptosis in tissue samples from patients with CCA.CONCLUSIONS:22‐Oxa‐D3 effectively suppressed tumor growth in CCA‐inoculated mice and induced cellular apoptosis in tissue samples from patients with CCA. The current data encourage further investigation of 1,25(OH)2D3 or its analogues as therapeutic agents in the treatment of patients with CCA. Cancer 2010. © 2010 American Cancer Society.
A phase 2 study of the oral mammalian target of rapamycin inhibitor, everolimus, in patients with recurrent endometrial carcinoma
Authors: Slomovitz Brian M. , Lu Karen H. , Johnston Taren , Coleman Robert L. , Munsell Mark , Broaddus Russell R. , Walker Cheryl , Ramondetta Lois M. , Burke Thomas W. , Gershenson David M. , Wolf Judith 
Published: August 2010

AbstractBACKGROUND:Dysregulation of phosphatase and tensin homolog (PTEN) and the gene that encodes the p110α catalytic subunit of phosphatidylinositol‐3‐kinase (PI3K), PIK3CA, are the most common mutations in endometrial carcinoma (EC). Loss of PTEN or activation of PIK3CA results in constitutive activation of AKT, which leads to up‐regulation of mammalian target of rapamycin (mTOR). Everolimus is an oral rapamycin analog that acts by selectively inhibiting mTOR.METHODS:A single‐institution, open‐labeled, phase 2 study of everolimus in patients with measurable recurrent EC who had failed at least 1 and no more than 2 prior chemotherapeutic regimens was performed. Everolimus was administered at a dose of 10 mg orally daily for 28‐day cycles. Patients were treated until disease progression or toxicity. The primary endpoint was clinical benefit response (CBR), defined as a confirmed complete or partial response or prolonged stable disease (SD) (≥8 weeks). Inclusion was limited to patients with endometrioid histology.RESULTS:A total of 35 patients were enrolled (median age, 58 years; range, 38‐81 years). A total of 81 cycles were administered. Twelve of 28 (43%) evaluable patients had not developed disease progression at the time of the first objective evaluation (8 weeks). All these patients had SD (median, 4.5 cycles; range, 2‐10 cycles). Six of the 28 (21%) patients had a confirmed CBR at 20 weeks of therapy. Patients with CBR discontinued treatment because of toxicity (6 patients), disease progression (5 patients), and noncompliance (1 patient). Seven patients were unevaluable after receiving ≤1 cycle because of toxicity (5 patients) or noncompliance (2 patients). The most common drug‐related toxicities were fatigue, anemia, pain, lymphopenia, and nausea.CONCLUSIONS:Everolimus demonstrated encouraging single‐agent CBR in pretreated patients with recurrent endometrioid EC. Future studies will evaluate this agent in combination with hormonal and/or cytotoxic therapy. Cancer 2010. © 2010 American Cancer Society.
Causes of oral tongue cancer treatment failures: Analysis of autopsy cases
Authors: Takagi Minoru , Kayano Teruo , Yamamoto Hajime , Shibuya Hitoshi , Hoshina Masao , Shioda Shigetoshi , Enomoto Shoji 
Published: August 2010

AbstractEighty‐three autopsy cases of squamous cell carcinoma of the oral tongue were reviewed to identify retrospectively the causes of treatment failure. The cure rate for the primary cancers at autopsy was 48.2% (40 of 83). Regional lymph node metastases were found in 71.1% (59 of 83). Regional metastases and/or juxtaprimary recurrence frequently spread continuously and diffusely, forming bulky neck tumors in 38.6% (32 of 83). The incidence of distant lymph node metastasis (below the clavicle) and hematogenous metastasis was 35.4% (29 of 82) and 58.5% (48 of 82), respectively. The lung was the most common site of hematogenous metastases (52.4%, 43 of 82). Hematogenous metastasis occurred more frequently in the younger age group (< 40 years of age;P= 0.03). Distant lymph node metastases were identified in the lung hilar, bifurcation, and paratracheal nodes in 89.7% (26 of 29) and had a statistically significant association with lung hematogenous metastasis. Univariate analysis revealed that gross appearance, tumor stage, clinical stage, presence of cervical lymph node metastasis, and interval from NO to NX were significant predictors of survival time (duration from initial treatment to death). Rupture of the neck vessels was fatal in eight patients (9.6%), and hypercalcemia was seen in six (7.2%). Pulmonary infection was the direct cause of death in 33.7% of patients (28 of 83). Secondary malignant lesions occurred in 22.9% (19 of 83).
Hereditary nonpoiyposis colorectal cancer (lynch syndrome II): Diploid malignancies with prolonged survival
Authors: Frei J. V. 
Published: August 2010

AbstractDNA flow cytometry was performed on 44 paraffin blocks from 16 specimens of 11 lesions in five patients from two families identified as probably having the dominant gene of the Lynch Type II syndrome. All but one specimen showed diploidy, although two such specimens were metastases and one a recurrence. The one aneuploid gastric biopsy was followed by a resection with diploidy in all 13 blocks from the malignancy and may represent a superficial change without clinical significance. The prolonged survival after discovery of malignancy in such families may be explained in part by diploidy of the lesions.
The association between cholangiooaroinoma and hereditary nonpolyposis colorectal carcinoma
Authors: Mecklin J.‐P. , Järvinen H. J. , Virolainen M. 
Published: August 2010

AbstractEighteen patients with a biliopancreatic carcinoma in 15 different cancer family syndrome (CFS) families were studied. Only families with three or more first‐degree relatives with colorectal carcinoma were included, and other characteristics of CFS were required in at least two cases. In 14 patients, the histologic specimen was available for reevaluation. In 11 (79%), the tumor was confirmed as a carcinoma of the biliary tract or papilla of Vater. In three (21%), carcinoma of the pancreas was the most probable alternative. In all four patients without histologic reevaluation, the diagnosis had been carcinoma of the biliary tract. This study suggests that carcinoma of the biliary tract or papilla of Vater is associated more commonly with CFS than with carcinoma of the pancreas. In this respect, CFS resembles familial adenomatosis coli, in which this association previously has been established.
High incidence of ras gene mutation in intrahepatic cholangiocarcinoma
Authors: Tada Minoru , Omata Masao , Ohio Masao 
Published: August 2010

AbstractThe DNA sequences around codons 12, 13, and 61 of the ras gene were analyzed by polymerase chain reaction and direct sequencing in 18 intrahepatic cholangiocar‐cinomas. The ras gene mutations were found in 9 of 18 (50%): 6 in K‐ras codon 12, 1 in K‐ras codon 13, 1 in K‐ras codon 61, and 1 in N‐ras codon 12. The incidence of mutations was higher in the hilar type of intrahepatic cholan‐giocarcinomas, especially when these tumors were large. The incidence and spectrum of the mutations were almost the same as those reported in colon cancers, possibly indicating similar etiologic agent(s) in the carcinogenesis of both cancers.
Lymphoma in inflammatory bowel disease
Authors: Greenstein Adrian J. , Mullin Gerard E. , Strauchen James A. , Heimann Tomas , Janowitz Henry D. , Aufses Arthur H. , Sachar David B. 
Published: August 2010

AbstractNine patients with lymphoma occurring in association with inflammatory bowel disease were admitted to The Mount Sinai Hospital between 1960 and 1983. Five (two men and three women) occurred among 1156 patients (0.43%) with ulcerative colitis (UC) and four (men), among 1480 patients (0.27%) with Crohn's disease (CD), a strong male preponderance in the latter group. In all four of the patients with CD and in four of the five patients with UC, the lymphomas were extraintestinal. The mean age of onset of UC in these patients was late (46 years, 19 years older than in our overall series), with lymphomas occurring a mean of only 12 years later. By contrast, patients with CD had bowel disease much younger (mean age, 26 years), and their lymphomas appeared after a longer disease duration (mean, 24 years). The risk factors for the one patient with colonic lymphoma were similar to those with colitis‐associated colorectal carcinoma: extensive and long‐standing colitis and relatively young age when malignant disease developed. Four of the patients with lymphoma had associated colonic carcinoma; in three of them, the carcinoma appeared within the first decade of colitis, an unusual occurrence. A second malignant lesion also occurred in three patients with UC.
Primary biphasic lymphoplasmacytic lymphoma of the lung: A mucosa‐associated lymphoid tissue lymphoma with compartmentalization of plasma cells in the lung and lymph nodes
Authors: Chetty R. , Close P. M. , Timme A. H. , Willcox P. A. , Forder M. D. 
Published: August 2010

AbstractA primary mucosa‐associated lymphoid tissue lymphoma of the lung in a 27‐year‐old man was found. The tumor was composed mainly of centrocyte‐like cells and plasma cells. These two components were demarcated sharply from each other, resulting in a zoning or biphasic pattern. This characteristic pattern also was present in the involved regional lymph nodes. Monoclonality of tumor cells was shown immunohistochemically and by in situ hybridization techniques. This article also highlights the use of in situ hybridization in detecting light chain mRNA in paraffin sections.
Relationship between immune response to melanoma vaccine immunization and clinical outcome in stage II malignant melanoma
Authors: Bystryn Jean‐Claude , Oratz Ruth , Roses Daniel , Harris Matthew , Henn Milagros , Lew Robert 
Published: August 2010

AbstractThe authors investigated whether there was a relationship between the induction of a delayed‐type hypersensitivity (DTH) response to melanoma vaccine immunization and disease recurrence. They studied prospectively 94 evaluable patients with surgically resected Stage II malignant melanoma who were immunized to a partially purified, polyvalent, melanoma antigen vaccine. The DTH response to skin tests to the vaccine was measured before treatment and at the fourth vaccine immunization. Vaccine treatment induced a strong DTH response in 29 (31%) patients, an intermediate response in 24 (25%), and no response in 41 (44%). The median disease‐free survival (DFS) of patients with a strong, intermediate, and no DTH response to vaccine immunization was more than 72 months, 24 months, and 15 months, respectively. The relationship between an increase in the DTH response and a prolonged DFS was statistically significant (P = 0.02); clinically meaningful (the median DFS of patients with a strong DTH response was 4.7 years longer than that of nonresponders); and, by multivariate analysis, independent of disease severity or overall immune competence. These findings suggest, but do not prove, that vaccine treatment can slow the progression of melanoma in some patients.
Expression of cell adhesion molecules in human melanoma cell lines and their role in cytotoxicity mediated by tumor‐infiltrating lymphocytes
Authors: Pandolfi Franco , Trentin Livio , Boyle Lenora A. , Stamenkovic Ivan , Byers H. Randolph , Colvin Robert B. , Kurnick James T. 
Published: August 2010

AbstractThe role of cell adhesion molecules (CAM) LFA1, ICAM1, LFA3, VLA1, VLA4, CD29, CD44, and CD56 in tumor‐infiltrating lymphocyte (TIL) and natural killer cell (NK)‐mediated killing of target cells was studied. Melanoma cell lines and autologous TIL were derived from seven patients with metastatic melanoma, and cytotoxicity assays were done in the presence and absence of monoclonal antibodies (MoAb) to CAM expressed on melanoma cells or TIL. The melanoma cell lines analyzed were all positive for CD29 and LFA3 expression, negative for LFA1 expression, but showed variable expression of ICAM‐1, VLA1, VLA4, CD44, and CD56. The effects of anti‐CAM antibodies on TIL‐mediated melanoma killing fell into three categories: (1) consistent inhibition of TIL‐mediated killing was observed when melanoma cells were pretreated with anti‐ICAM1 and anti‐LFA‐3 MoAb or when TIL were pretreated with anti‐LFA1; (2) no effect was observed when melanoma cells were pretreated with anti‐CD56; or (3) a discreet, but significant, inhibition was observed when target cells were pretreated with anti‐CD29, anti‐VLA1, anti‐VLA4, and anti‐CD44. Cytotoxicity was significantly enhanced by pretreatment of target cells with γ‐interferon (7‐IFN), although γ‐IFN did not augment surface expression of the CAM studied. The NK‐mediated killing of K562 cells was blocked by anti‐LFA1, anti‐CD18, and anti‐ICAM, and partially inhibited by anti‐CD44 MoAb. Together, these results suggest that several accessory CAM may play a role in regulating cellular cytotoxicity. Because cytotoxicity generally correlated with the level of expression of CAM in melanoma cells, weak CAM surface expression may provide a means for melanomas to escape immune surveillance.