699-P: Gender Differences in Psychosocial Outcomes according to BMI and Waist Circumference among Adults Living with Type 1 Diabetes—A Cross-Sectional BETTER Analysis
Authors: BONHOURE ANNE , LALANNE-MISTRIH MARIE-LAURE , TALBO MERYEM K. , BOUDREAU VALERIE , MESSIER VIRGINIE , BANDINI AUDE , SECOURS LAURENCE , PAYETTE MARIE-CHRISTINE , FONTAINE SONIA , BRAZEAU ANNE-SOPHIE , RABASA-LHORET RÉMI P.R. 
Published: June 2024

Introduction & Objective: Although the association between psychosocial outcomes and a higher BMI is well known in the general population, there are few studies among people living with type 1 diabetes (PwT1D). The aim of this study is to investigate the associations between psychosocial outcomes and BMI groups or waist circumference (WC), for men and women.
Methods: A cross-sectional analysis of the BETTER registry based on patient-reported outcomes of adult PwT1D (BMI n=1028; WC n=435) stratified by gender and classified into three BMI groups: &lt;25 (Group A); 25-29 (Group B); ≥30 (Group C) kg/m2 and WC groups: &lt;88/&lt;102 and ≥88/≥102cm (women/men respectively). Student’s T-tests, one-way ANOVAs, and χ2 logistic regression searched for associations between BMI or WC groups and psychosocial outcomes: depression, diabetes distress (DD), and diabetes-related stigmatization.
Results: Of the 1028 PwT1D, 66% were women and the average BMI, WC, age, T1D duration were: 26 kg/m2, 92 cm, 45 years, and 24 years, respectively. For BMI classes, 460 adults (45%) were in group A, 356 (35%) group B, and 212 (21%) group C. Women in group C, compared to group A, had more symptoms of depression (p&lt;0.001), more prescriptions for depression (p&lt;0.001), and reported higher DD (p&lt;0.001). Women in group B and C reported feeling more stigmatized due to their diabetes (p&lt;0.001) than those in group A. There were no differences between BMI classes in men, and they reported fewer symptoms of depression and lower DD and diabetes stigmatization than women. In women, 148 (52%) had a WC &lt;88 and 135 (48%) ≥88 cm, while 104 men (68%) had a WC &lt;102 and 48 (32%) ≥102 cm. There were no differences between WC groups in women. Compared to the WC&lt;102 group, men with a WC≥102 cm had more symptoms of depression and more prescriptions for depression (p&lt;0.016).
Conclusion: In adult PwT1D, less favorable psychosocial outcomes are associated with a BMI ≥30 kg/m2 in women and WC ≥102 cm in men.

Disclosure
A. Bonhoure: Consultant; Dexcom, Inc. M. Lalanne-Mistrih: Other Relationship; Novo Nordisk, SANOFI AVENTIS FRANCE, ViiV Health Care, SOS Oxygene Antilles, MEDICALIA, SEPRODOM Antilles, DINNO SANTE. M.K. Talbo: None. V. Boudreau: None. V. Messier: None. A. Bandini: None. L. Secours: None. M. Payette: None. S. Fontaine: None. A. Brazeau: Other Relationship; Dexcom, Inc. Research Support; Canadian Institutes of Health Research, Juvenile Diabetes Research Foundation (JDRF), Diabète québec, Fonds de recherche du Québec en Santé. R.P.R. Rabasa-Lhoret: Other Relationship; Abbott, AstraZeneca, Bayer Inc., Boehringer-Ingelheim, Dexcom, Inc. Research Support; Diabetes Canada. Other Relationship; Eli Lilly and Company. Research Support; Cystic Fibrosis Canada, Canadian Institutes of Health Research, FFRD - Fondation Francophone pour la Recherche du Diabète. Other Relationship; Janssen Pharmaceuticals, Inc. Research Support; Juvenile Diabetes Research Foundation (JDRF). Other Relationship; Novo Nordisk, GlaxoSmithKline plc. Consultant; HLS Therapeutics Inc., Insulet Corporation. Speaker's Bureau; CPD Networks. Other Relationship; Medtronic. Consultant; Pfizer Inc. Speaker's Bureau; Tandem Diabetes Care, Inc. Other Relationship; Sanofi. Speaker's Bureau; Vertex Pharmaceuticals Incorporated. Research Support; SFD - Société Francophone du Diabète.