bluuebunny/crossref_metadata_2025_split huggingface dataset:
Stereochemical studies. Part 67. Saturated heterocycles. Part 52. The mass spectra of some condensed skeleton 1,3‐oxazin‐4‐one derivatives
Authors: Vékey Károly , Tamás József , Fülöp Ferenc , Bernáth Gábor 
Published: April 2009

AbstractThe mass spectrometric behaviour of twenty saturated heterocyclic compounds with a 1,3‐oxazin‐4‐one moiety fused with cis or trans anellation to a cycloalkane ring (C5‐C8) was studied. The roles of the C‐2 and N‐3 substituent(s) were found to be characteristic, while the size of the cycloalkane ring seemed to be unimportant. Some fragmentation processes involving breakdown of the oxazinone ring of the cis or trans isomers displayed significant stereoselectivity. A striking new decomposition process involving significant chlorine elimination from the molecular ion of some 2‐p‐chlorophenyl derivatives was observed and was studied in some detail.
Analogs of 3‐(1‐phenyl‐3‐oxobutyl)‐4‐hydroxycoumarin (warfarin) prepared from substituted salicylic acids
Authors: Obaseki Andrew O. , Steffen James E. , Porter William R. 
Published: April 2009

AbstractSome derivatives of salicylic acid containing substituents meta to the carboxyl group were used to prepare analogs of the anticoagulant drug warfarin, 3‐(1‐phenyl‐3‐oxobutyl)‐4‐hydroxycoumarin, containing substituents in either the 6‐or 8‐position of the courmarin ring. When the substituent was the hydroxyl group, the resulting products are previously identified metabolites of warfarin. The substituted salicylic acid is first acetylated with acetic anhydride, then either converted to the acid chloride and condensed with diethyl malonate in the presence of sodium hydroxide or converted to the mixed anhydride with formic acid and condensed with ethoxymagnesium diethyl malonate to yield, in either case, the corresponding 3‐carbethoxy‐4‐hydroxycoumarin substituted in the 6‐ or 8‐position of the coumarin ring. These compounds readily condense with benzalacetone to form the corresponding substituted warfarin in the presence of 5 mole % tertiary amine catalyst. This method offers an improved route for the synthesis of 8‐hydroxywarfarin.
Cycloadditions of N‐Aryl‐C‐(trifluoromethyl)nitrilimines with dimethyl fumarate and maleate
Authors: Tanaka Kiyoshi , Maeno Seiji , Mitsuhashi Keiryo 
Published: April 2009

AbstractThe cycloadditions of N‐aryl‐C‐(trifluoromethyi)nitrilimines 1, generated in situ from various precursors, with dimethyl fumarate and maleate are described. N‐Aryltrifluoroacetohydrazonoyl bromides 2 reacted with fumarate in the presence of triethylamine to give the trans‐4,5‐dimethoxycarbonylpyrazolines 4 whereas the reactions with maleate afforded the 4,5‐dimethoxycarbonylpyrazoles 5 as well as 4. In the reactions with the chloride 6 under the more drastic conditions, both fumarate and maleate gave the pyrazole 5a. From thermolysis of the oxadiazaphosphole 8, the trans‐pyrazoline 4a was formed in both cases of fumarate and maleate. The preparation of the cis‐pyrazoline 9 was attempted from 8 and maleic anhydride but 9 was found to be so unstable as to be epimerized under the mild conditions.
Ring‐transformation of 1,2,4‐oxadiazines. Raney nickel hydrogenation of Z‐3‐aryl‐5,6‐dihydro‐5‐(substituted)methylene‐4H‐1,2,4‐oxadiazine derivatives
Authors: Tabei Katsumi , Kawashima Etsuko , Takada Toyozo , Kato Tetsuzo 
Published: April 2009

AbstractRaney nickel hydrogenation of Z‐3‐aryl‐5‐(ethoxycarbonyl)methylene‐5,6‐dihydro‐4H‐1,2,4‐oxadiazine (1a‐c) affords 2‐aryl‐6‐hydroxymethyl‐4‐pyrimidinone (2) and ethyl (2‐aryl‐4‐oxazolyl)acetate (3). A similar hydrogenation of Z‐5‐arylcarbarnoyl)methylene‐5,6‐dihydro‐3‐phenyl‐4H‐1,2,4‐oxadiazine (1d‐f) gives E‐4‐(arylcarbamoyl)methylene‐2‐phenyl‐2‐oxazoline (5), 4‐(arylcarbamoyl)methyl‐2‐phenyloxazole (6), and Z‐4‐(aryl‐carbamoyl)methylene‐2‐phenyl‐2‐oxazoline (7).
Styryl dyes derived from bis boron diketonates
Authors: Reynolds George A. , Chen Chin H. 
Published: April 2009

AbstractBis boron diketonates are prepared from β‐diketones or o‐acylphenols or naphthols with boron trichloride or boron tribromide. The bis boron diketonates that contain methyl groups reacted with some aromatic aldehydes, giving styryl dyes, most of which showed high extinction coefficients.
Facile synthesis of novel 3‐quinoxalinyl‐1,5‐benzodiazepines via ring transformation. Stable tautomers in the 1,5‐benzodiazepin‐2‐one ring system
Authors: Kurasawa Yoshihisa , Okamoto Yoshihisa , Ogura Kuniyoshi , Takada Atsushi 
Published: April 2009

AbstractNovel 3‐quinoxalinyl‐1,5‐benzodiazepines 4, 5, 6, 9, 10 were synthesized via the ring transformation of 3‐(N,N‐dimethylcarbamoyl)furo[2,3‐b]quinoxaline hydrochloride (1). The 3‐quinoxalinyl‐1,5‐benzodiazepine hydrochlorides 4 and 6 are the tautomers of the N1′‐H (or N5‐H) form and the C3‐H form, respectively, which are stable in solid and solution. However, 4 (NH form) was found to be converted into 6 (C3‐H form) by refluxing in acetic acid. The individual spectral evidences and different reactivity of these tautomers are described.
Synthesis of C‐3 side‐chain carboxylic acid cannabinoid derivatives
Authors: Borne Ronald F. , Mauldin Scott C. 
Published: April 2009

AbstractBased upon the structural similarities of cannabinoid derivatives which inhibit the biosynthesis of prostaglandins with those of the potent inhibitor, indomethacin, several cannabinoid derivatives possessing C‐3 side chain carboxylic acid functionalities were prepared.
Quninone chemistry. Synthesis of 3‐methoxy[2, 1]benzisoxazoleand 3‐methoxynaphth[2,3‐c]isoxazolequinones
Authors: Torres Tomás , Eswaran S. V. , Schäfer Wolfram 
Published: April 2009

Abstract[2, 1]Benzisoxazole‐4, 7‐quinones 4 are prepared by an improved method using oxidative amination of 1 to give 2, followed by amine exchange to 3 and cyclization with lead tetraacetate. Naphth[2,3‐c]isoxazole‐4,9‐quinone 7 is obtained from 5 by an analogous procedure.
Quninone chemistry. Synthesis of 3‐dialkylsulfoximido‐ and 2‐dialkyl‐sulfimido‐3‐carbomethoxy‐1,4‐benzo‐ and naphthoquinone derivatives
Authors: Torres Tomás , Eswaran S. V. , Schäfer Wolfram 
Published: April 2009

Abstract3‐Methoxy[2, 1]benzisoxazole‐4, 7‐quinones 1 and naphth[2,3‐c]isoxazole‐4,9‐quinone 4 react with dimethyl sulfoxides to give sulfoximidoquinones 2 and 5, sulfimidoquinones 8 and 11 respectively as major products.
Préparation de dithiényl‐2‐éthène‐1,2, de dithiényl‐2‐pyrimidine‐2,4 et de dithiényl‐2‐pyridazine‐3,6
Authors: Monthéard Jean‐Pierre , Dubois Jean‐Claude 
Published: April 2009

AbstractLa condensation du réactif de Grignard du bromo‐2‐thiophène avec les dérivés bihalogénés, tels que le di‐chloro‐1,2‐éthène (Z), la dichloro‐2,4‐pyrimidine et la dichloro‐3,6‐pyridazine, en présence de catalyseur à base de métal de transition permet d'obtenir, en une seule étape, des dérivés polycycliques, comportant deux noyaux thiophènes.
Antimykotische wirkstoffe. XIX. 4,6‐Disubstituierte 2‐(cyanamino)pyrimidine
Authors: Kreutzberger Alfred , Sellheim Michael 
Published: April 2009

AbstractAus der Umsetzung von Dicyandiamid (1) mit β‐Diketonen (2a‐c) gehen die 2‐Cyanaminopyrimidine (3a‐c) hervor. Strukturtyp 3 wird durch spektroskopische Daten gestützt, während gleichzeitig eine 1‐Cyan‐2‐imino‐struktur (4) ausgeschlossen wird. Verbindung 3a zeigt fungistatische und nematizide Wirkungen.
Synthesis of 2‐hydroxy‐2‐phenylethylamino derivatives as potential α‐adrenergic blocking agents
Authors: Alvarez M. , Granados R. , Lavilla R. , Salas M. 
Published: April 2009

AbstractThe synthesis of N,N'‐bis[6‐(2‐hydroxy‐2‐phenylethylamino)hexyl] cystamines 4, and N‐(2‐hydroxy‐2‐phenylethyl)‐1,6‐hexanediamines 6 are described. Compounds 4 were obtained by condensation of the requisite epoxide 2 with 3‐(6‐aminohexyl)‐1,3‐thiazolidine followed by dimerization with opening of the thiazolidine ring. A similar method was used for the preparation of compounds 6. In order to prepare 4j (N,N'‐bis{6‐[2‐hydroxy‐2(3,4‐dihydroxyphenyl)ethylamino]hexyl}cystamine), several procedures were tested; the method of choice involved the use of 3,4‐dihydroxybenzaldehyde with both hydroxy groups protected as methoxymethyl ethers.
Synthesis of thieno[2,3‐c:5,4‐c]dipyridine and the one electron transfer properties of its dimethyl diquaternary salt
Authors: Attalla Moetaz I. , Summers Lindsay A. 
Published: April 2009

AbstractThieno[2,3‐c:5,4‐c]dipyridine is synthesised by reaction of 3,3′‐thiobispyridine with sodium and liquid ammonia in dimethylformamide. It forms a diquaternary salt with excess methyl iodide. The salt is reversibly reduced to a stable blue‐green radical cation in aqueous solution at a potential (Eσ) of ‐0.38V.
The reaction of 5‐aminoimidazole‐4‐carbohydrazides with orthoesters
Authors: Bridson P. K. , Davis R. A. , Renner L. S. 
Published: April 2009

AbstractThe reaction of 5‐aminoimidazole‐4‐carbohydrazides with orthoesters is shown to yield 1‐amino‐9‐alkyl‐hypoxanthines. Similar reaction of anthranilic acid hydrazide is shown to yield 3‐amino‐4‐quinazolone, and not 1,4‐dihydro‐5H‐1,3,4‐benzotriazepin‐5‐one as previously reported.
Synthèse d'oxo‐2 pyranno[3,2‐c]benzopyrannes et d'oxo‐2 pyranno[3,2‐d]benzoxépines
Authors: Sacquet Marie‐Claude , Bellassoued‐Fargeau Marie‐Claude , Graffe Bernadette , Maitte Pierre 
Published: April 2009

AbstractLa condensation directe de chromanones‐4 ou de l'homochromanone‐5, en milieu basique, avec l'éthoxy‐méthylène malonate d'éthyle ou l'éthoxyméthylène malononitrile conduit à la formation d'un système α‐pyronique. Le rendement en carbéthoxy ou en carbamoyl pyrone varie en fonction de la position et de la nature des substituants sur les cétones de départ.
Covalent amination of 3,6‐dinitro‐1,8‐naphthyridines
Authors: Woźniak M. , Van Der Plas H. C. , Tomula M. , Van Veldhuizen A. 
Published: April 2009

AbstractThe preparation of 3,6‐dinitro‐2‐R‐1,8‐naphthyridines (1, R = OH, NH2, OC2H5, Cl) is described and their addition patterns with liquid ammonia are studied. Compound 1 (R = OH, NH2) gives with liquid ammonia at ‐ 45° as well as at room temperature formation of the covalent ó‐adduct 4‐amino‐1,4‐dihydro‐3,6‐dinitro‐2‐R‐1,8‐naphthyridine (2, R = OH, NH2). Compound 1 (R = OC2H5) yields with ammonia at ‐ 45° two σ‐adducts, i.e. the C‐4 adduct (2, R = OC2H5) and the C‐5 adduct 5‐amino‐5,8‐dihydro‐3,6‐dinitro‐2‐R‐1,8‐naphthyridine (3, R = OC2H5). The ratio is about 50:50. This ratio depends on the temperature; at room temperature the C‐5 adduct is more favoured. After staying overnight the ethoxy group has been exchanged for the amino group, yielding 2 (R = NH2). With 1 (R = Cl) both adducts 2 (R = CI) and 3 (R = CI) were formed, the C‐4 adduct 2 (R = CI) is more favoured at room temperature. Prolonged treatment with liquid ammonia leads to an exchange of the chloro atom by the amino group, yielding 2 (R = NH2).
Proton and carbon‐13 nuclear magnetic resonance spectroscopy and conformational aspects of 5,6,7,8‐tetrahydro‐4‐chromanone derivatives
Authors: Dolmazon René , Gelin Suzanne 
Published: April 2009

AbstractThe 25 MHz 13C and 350 MHz 1H‐nmr spectra of the title compounds are reported. Conformational equilibria in variously substituted 5,6,7,8‐tetrahydrochromanones are discussed. Compounds bearing a t‐butyl group at the 6 position appear to be conformationally homogenous.
Imino‐bridged heterocycles. IV . A facile synthesis of sulfenimines derived from diaryl ketones
Authors: Brenner Daniel G. , Cavolowsky Kathleen Mensler , Shepard Kenneth L. 
Published: April 2009

AbstractEfficient, high‐yield syntheses of N‐diarylmethylene sulfenamides (sulfenimines) have been developed under mild laboratory conditions. Diaryl ketones have been shown to form ketimines readily by condensation with ammonia in the presence of titanium tetrachloride.
A novel synthesis of pyrido[2,3‐α]indolizine
Authors: Ross John R. , Sowell J. Walter 
Published: April 2009

AbstractThe synthesis of a new pyridoindolizine, in particular, pyrido[2,3‐α]indolizine, was carried out using 2‐methyl‐3‐t‐butoxycarbonyl‐4‐aminopyrrole as the starting material.
Studies on the synthesis and interconversion of isomeric triazolotheinopyrimidines. Part II. Effect of 5‐substituents on the dimroth rearrangement of 1,2,4‐triazolo[4,3‐c]thieno[3,2‐e]pyrimidines
Authors: Shishoo C. J. , Devani M. B. , Ullas G. V. , Ananthan S. , Bhadti V. S. 
Published: April 2009

AbstractThe triazolothienopyrimidines obtained by the cyclization of 4‐hydrazino‐2‐phenylthieno[2,3‐d]pyrimidines with triethyl orthoformate or formic acid presumed to be the triazolo[2,3‐c] isomers are now assigned the 5‐phenyl‐1,2,4‐triazolo[4,3‐c]thieno[3,2‐e]pyrimidine structure. While these [4,3‐c]triazoles resist isomerization under acidic conditions, they undergo isomerization to 5‐phenyl‐1,2,4‐triazolo[2,3‐e]thieno[3,2‐e]pyrimidines under basic conditions.
Spiro[(2,3‐dihydro‐2‐oxo‐imidazo[1,2‐a]pyridine)‐3,3‐(3,4‐dihydro‐2‐methyl‐4‐oxo‐2H‐1,2‐benzothiazine 1,1‐dioxide)]‐A novel product derived from piroxicam
Authors: Norris Charles P. , Berke Helen , Lombardino Joseph G. , Bordner Jon 
Published: April 2009

AbstractA novel compound, spiro[(2,3‐dihydro‐2‐oxo‐imidazo[1,2‐a]pyridine)‐3,3‐(3,4‐dihydro‐2‐methyl‐4‐oxo‐2H‐1,2‐benzothiazine 1,1‐dioxide)] (3), was isolated during an attempt to convert 4‐hydroxy‐2‐methyl‐N‐(2‐pyridinyl)‐2H‐1,2‐benzothiazine‐3‐carboxamide 1,1‐dioxide (1) (Piroxicam) to an O‐trifluoromethanesulfonyl ester. A possible mechanism is offered to explain this unusual transformation.
Synthesis of 8‐substituted 5‐deazaflavins
Authors: Link P. A. J. , Van Der Pias H. C. , Müller F. 
Published: April 2009

AbstractTo obtain 5‐deazaflavins exhibiting red‐shifted light absorption spectra, a number of C(8) substituted 5‐deazaisoalloxazines were synthesized. This was accomplished a) by the oxidative cyclization of 5,5′‐arylmethylenebis(6‐methylaminouracil) derivatives and b) by the cyclization of N‐methylanilinouracil derivatives with a one‐carbon reagent. The latter method led to the formation of impure products. Condensation and oxidation reactions with the π‐electron deficient C(8) methyl group in 5‐deazalumiflavin did not occur. Introduction of substituents at the C(8) position caused a bathochromic shift that varied between 10 and 40 nm.
Studies on furan derivatives. X. Preparation of 2‐Methylfuro[2,3‐c]quinoline Derivatives
Authors: Usui Toshinao , Tsubone Yasuo , Tanaka Akira 
Published: April 2009

Abstract4‐Chloro‐2‐methylfuro[2,3‐c]quinoline (IV) was synthesized from ethyl 3‐(2‐nitrophenyl)‐5‐methyl‐2‐furoate and IV was allowed to react with some nucleophiles to afford the corresponding 4‐substituted 2‐methylfuro‐[2,3‐c]quinoline derivatives, respectively. On treatment of IV with potassium azide in dimethylsulfoxide, 2‐methylfuro[2,3‐c]tetrazolo[1,5‐a]quinoline was formed path azido‐tetrazolo isomerization. 2‐Methylfuro‐[2,3‐c]quinoline was prepared by the reduction of IV.
Phosphorus pentoxide in organic synthesis. XX. Synthesis of N‐aryl‐7H‐pyrrolo[2,3‐d]pyrimidin‐4‐amines
Authors: Jørgensen Anker , El‐Bayouki Khairy A. M. , Pedersen Erik B. 
Published: April 2009

AbstractN‐Aryl‐7H‐pyrrolo[2,3‐d]pyrimidine‐4‐amines 7 were prepared in 30‐67% yields by treating N7‐(1‐phenyl‐ethyl)pyrrolo[2,3‐d]pyrimidin‐4(3H)‐ones 2 with a mixture of phosphorus pentoxide, triethylamine hydrochloride, and an appropriate arylamine hydrochloride at 240° for 3‐7 hours.
The chemistry of polycyclic arene imine. VI. 1‐[N,N‐di‐(2‐propenyl)‐9‐phenanthreneamine‐10‐yl]‐1a,9b‐dihydrophenanthro[9,10‐b]azirine an unusual allylation product of phenanthrene 9,10‐imine
Authors: Weitzberg Moshe , Aizenshtat Zeev , Blum Jochanan 
Published: April 2009

AbstractPhenanthrene 9,10‐imine (1) was shown to react with allyl bromide and 50% aqueous sodium hydroxide under phase transfer catalysis conditions to give the title compound 3 as the only product. The starting imine 1 is assumed to undergo initially bis alkylation to form an N,N‐di‐(2‐propenyl)phenanthrene 9,10‐iminium salt (4) which, in turn, is attacked by a deprotonated phenanthrene imine anion (5). The structure of 3 has been determined by a single crystal X‐ray diffraction analysis.
Potential anticonvulsants. X. (Reissert compounds studies. LI.) 1‐methyl‐4‐(1‐isoquinolinyl)piperidin‐4‐ol and related compounds
Authors: Popp Frank D. , Kant Joydeep 
Published: April 2009

AbstractThe anion of isoquinoline Reissert Compounds has been condensed with 4‐piperidones and pyridinecarb‐oxaldehydes to give esters which are easily hydrolyzed to alcohols. The anticonvulsants activity of these alcohols is reported and several are active in the maximal electroshock seizure test.
The reductive metalation of 9‐phenylacridine
Authors: Smith James G. , Fogg Deryn E. 
Published: April 2009

AbstractThe reductive metalation of 9‐phenylacridine by sodium to a dianion is described and the reactions of the dianion with electrophiles investigated. Reactions of the dianion with methanol, dimethyl sulfate, X(CH2)nX (n = 2,3,4, X = Cl, Br), and methyl chloroformate were studied. Reactions occurred exclusively at the 9 and 10 positions forming 9,10‐dihydro‐9‐phenylacridine derivatives. Of particular interest was the fact that the dianion was dialkylated with 1,2‐dichloroethane but monoalkylated at the 9‐position with 1,3‐dichloropropane and 1,4‐dichlorobutane. These results are compared to those obtained with dianions derived from other heterocyclic systems and analyzed using Baldwin's Rules for Ring Closure.
Mass spectrometry of modified nucleic acid bases and nucleosides. 2. Class II mesoionic nucleosides and bases derived from thiazolo[3,2‐a]pyrimidine‐5,7‐diones
Authors: Schubert Ernst M. , Schram Karl H. , Glennon Richard A. 
Published: April 2009

AbstractThe mass spectral characteristics of novel Class II mesoionic heterocyclic bases and nucleosides based on the thiazolo[3,2‐a]pyrimidine‐5,7‐dione system have been examined using low and high resolution mass spectrometry and metastable ion analysis. The mass spectra of these Class II mesoionic nucleosides differ significantly from the spectra of “normal” nucleosides by the absence of fragment ions associated with the base plus portions of the sugar. The difference in fragmentation is rationalized on the basis of exclusive localization of the radical‐charge site in the aglycone, a result of the mesoionic structure of these molecules. The fast atom bombardment (FAB) mass spectra of a Class I mesoionic nucleoside, 7‐methylguanosine, is compared to the FAB mass spectra of the Class II mesoionic nucleosides.
Dication ethers. 7. Dication ether salts from cyclic bisureas
Authors: Maas Gerhard , Brückmann Ralf , Feith Bernhard 
Published: April 2009

AbstractThe bicyclic bisureas 2 react with triflic anhydride to give the dication ether salts 4. Further transformation of the remaining carbonyl groups of 4 into bis‐carbenium ether linkages was not possible. The monocyclic bisurea 8 yields the dicationic heterocycle 9 in an intramolecular fashion. The structure of 9, which is the first dication ether salt with an endocyclic ether linkage, was established by independent synthesis from 10 as well as by its hydrolysis to give the hemi‐protonated bisurea 11.
Resolution and absolute configuration of 1,2,3,5,6,10bβ‐hexahydro‐6α‐phenylpyrrolo[2,1‐α]isoquinoline (McN‐4612‐Z). A problem of determination of the enantiomeric purity for a tertiary amine
Authors: Maryanoff Bruce E. , Mccomsey David F. 
Published: April 2009

AbstractDetails for the resolution of 1,2,3,5,6,10bβ‐hexahydro‐6α‐phenylpyrrolo[2,1‐α]isoquinoline(1), a potent antidepressant‐like compound, into its enantiomers with di‐p‐toluoyltartaric acid (2)are reported. Enantio‐merically‐enrichedR‐(+)‐2‐phenylpyrrolidine was transformed into enantiomerically‐enriched1to determine enantiomeric purity and absolute stereochemistry for the resolved amines1. Thus, we ascertain that samples of (+)‐ and (—)‐1with an enantiomeric purity of ≥99% were prepared, and that bioactive (+)‐1possesses the 6S,10bRabsolute configuration. The enantiomeric purity of ≥99% was confirmed by 360‐MHz1H nmr examination of 1:1 diastereomeric salts formed from1or (—)‐1and (+)‐Mosher's acid (MTPA). The maximal optical rotation reported (ref 8) for (+)‐3(100% o.p.) was shown to correspond to 100% e.e.
Photodegradation of a 1,3,4‐thiadiazole‐urea herbicide. Isolation, characterization, X‐ray crystal structure and synthesis of photoproducts
Authors: Moorman Allan R. , Findak David C. , Ku Han San 
Published: April 2009

AbstractThe photodegradation of 1,3‐dimethyl‐1‐(2‐(3‐fluorobenzylthio)‐1,3,4‐thiadiazol‐5‐yl)urea as a thin film and in solution is described. The two photoproducts from thin‐film photolysis were characterized by spectral and synthetic methods. The X‐ray crystal structure of one of the photoproducts is also reported. The rearrangements were shown to involve an S‐to‐N benzyl migration, followed by a sulfur‐oxygen substitution.
Conversion des furfurylalkyl et arylcetones en derives de l'isocoumarine et de l'isoquinoleine
Authors: Aicart Michel , Mavoungou‐Gomès Louis 
Published: April 2009

AbstractPar catalyse acide, les produits de cycloaddition entre acétylenedicarboxylate de méthyle et furfurylalkyl ou arylcétones sont aromatisés en hydroxy‐6 phtalates de méthyle porteurs de groupements acétonyl ou phénacyl en position 3. Ces composés obtenus avec un rendement élevé constituent d'excellents intermédiates pour la préparation de dérivés polyfontionnels de l'isocoumarine et de l'isoquinoléine.
Synthèse de l'amino‐3 azétidine
Authors: Nisato Dino , Frigerio Marco 
Published: April 2009

AbstractLa synthèse de l'amino‐3 azétidine (4), un bio‐équivalent potentiel de la pipérazine ou amino‐4 pipéridine, est decrite en utilisant une reaction catalysee par transfert de phase solide‐liquide.
Bromination of sydnones. I. Reaction with 3‐arylsydnones containing electron‐donors on the aryl ring
Authors: Turnbull Kenneth 
Published: April 2009

AbstractBromination has been examined for a series of 3‐arylsydnones (1) with electron donors (dimethyl to dimethoxy) on the aryl ring. In no example was exclusive aryl ring bromination observed, however, exclusive sydnone ring bromination could be realized in every case. For two dimethoxyphenyl examples both aryl and sydnone ring bromination occurred.
Derivatives of benzo[5,6]cyclohepta[1,2‐b]thiophene. Synthesis of 2,3,7,8‐tetrahydro‐3‐oxothieno[1,2‐b]cyclohepta[5,6,7‐de]isoquinoline and 1,2,3,7,8,11b‐hexahydro‐3‐oxothieno[1,2‐b]cyclohepta[5,6,7‐de]isoquinoline
Authors: Sarriá Eva , Vega Salvador 
Published: April 2009

AbstractThe synthesis of the title compounds was carried out by cyclization via isocyanate of (E)‐4,5‐dihydro‐10H‐benzo[5,6]cyclohepta[1,2‐b]‐thiophene‐10‐ylideneacetic acid and 4,5‐dihydro‐10H‐benzo[5,6]cyclohepta[1,2‐b]‐thiophene‐10‐ylacetic acid respectively, which were obtained by the Wadsworth‐Emmons modification of the Wittig reaction of 4,5‐dihydro‐10H‐10‐oxobenzo[5,6]cyclohepta[1,2‐b]thiophene and triethyl phosphonacetate. The structures of these new compounds are described.
Condensation of enolates with O‐ethyl pyrrolidonium salts: An alternative to the orthoamide condensation
Authors: Mattson Ronald J. , Sowell J. Walter , Bryson Thomas A. 
Published: April 2009

AbstractO‐Ethyl‐N‐substituted pyrrolidonium fluoroborate salts were condensed under basic conditions with active methylene compounds to give vinylogous carbamates and cyanamides.