bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ba(SCN)2(H2O) complex of the cis‐syn‐cis isomer of 2,5,8,15,18,21‐hexaoxatricyclo[20,4,0,09,14]hexacosane(dicyclohexyl‐18‐crown‐6) [Ba(SCN)2(H2O)(C20H36O6)]
Authors: Dalley N. Kent , Sypherd Dirk , George Rose D. 
Published: April 2009

AbstractThe structure of the title compound has been redetermined. Hydrogenation of dibenzo‐18‐crown‐6 yields two conformational isomers which were proposed to be the cis‐syn‐cis and the cis‐trans‐cis isomers of dicyclohexyl‐18‐crown‐6. The previous study had established that the title complex contains the ligand which has the cis‐syn‐cis conformation but had resulted in some inaccurate bond lengths and also in an uncertainty regarding the presence of a water of hydration in the crystal. This study confirmed the report of the general conformation of the complex, resulted in more precise bond lengths and clearly established that a water of hydration was present at the crystal.
Angular heterocycles. A convenient synthesis of 6‐N‐(acetylanilino)‐5H‐benzo[a]phenothiazin‐5‐one, 6‐N‐(acetylanilino)‐5H‐benzo[a]phenoxazin‐5‐ones and their derivatives
Authors: Agarwal N. L. , Ghosh S. , Tripathi A. K. , Atal C. K. 
Published: April 2009

AbstractThe reaction of 2‐N‐(acetylanilino)‐3‐chloro‐1,4‐naphthoquinone (2) with bifunctional aromatic amines afforded angular heterocycles 6 and 7. Reductive acetylation of 7 provided o‐acyl 9 and O,N‐diacyl 10 derivatives depending upon the reaction conditions. The ir, uv, pmr and mass spectral data are also presented.
Methylpyridylbenz‐X‐azoles. lH NMR Study
Authors: Carpignano Rosarina , Savarino Piero , Barni Ermanno , Viscardi Guido 
Published: April 2009

AbstractThe shielding parameters of benz‐X‐azolyl substituents in various positions of the pyridine nucleus were determined by means of a regression analysis procedure. Analogously the shielding contributions of pyridyl substituents on homocyclic protons of benz‐X‐azoles were derived. The results evidence some interactions between the two heterocyclic systems when the benz‐X‐azolyl substituents are linked at the pyridine α‐position.
Mass fragmentation pattern of N‐ and O‐substituted 2‐morpholinols
Authors: Simonotti Luca , Pasqualucci Carmine , Pifferi Giorgio 
Published: April 2009

AbstractThe mass spectra of a series of N‐ and O‐substituted 2‐morpholinols were considered and the complex fragmentation pattern explained on the basis of evidences reported in the literature and of experimental data (high resolution, metastable ions). The primary fragmentations are given by inductive cleavage due to the heteroatoms, while ring contractions, through retro Diels‐Alder reactions, form most of the secondary pattern with different ions related to N‐ and O‐substituents. Moreover, hemiacetals in the tautomeric hydroxyaldehyde form undergo an α‐cleavage.
Phase transfer catalysis in N‐alkylation of the pharmaceutical intermediates phenothiazine and 2‐chlorophenothiazine
Authors: Gozlan Igal , Ladkani David , Halpern Mark , Rabinovitz Mordecai , Avnir David 
Published: April 2009

AbstractThe N‐alkylation of the two title compounds was studied, utilizing phase transfer catalysis (PTC) methods. Very mild reaction conditions were developed, especially for three‐carbon N‐alkylation. Of special interest is the high‐yield synthesis of N‐(3‐chloropropyl)‐2‐chlorophenothiazine. The results are discussed in terms of the classical PTC/OH− mechanisms.
1,2,4‐Triazines. 8. Reduction of 4‐methyl‐1,2,4‐triazin‐5(4H)‐ones with sodium borohydride. Regioselective preparation of dihydro‐1,2,4‐triazin‐5(4H)‐ones
Authors: Sanemitsu Yuzuru , Nakayama Yoshinori , Mizutani Masato , Oshie Kazuyuki 
Published: April 2009

AbstractReduction of 3‐methylthio‐1,2,4‐triazin‐5(4H)‐one (1a) with sodium borohydride afforded 3‐methylthio‐1,6‐dihydrotriazin‐5(4H)‐one (2b) selectively. 3‐Methylthio‐6‐t‐butyl‐1,2,4‐triazin‐5(4H)‐one (1d) reacted with sodium borohydride to give mainly 6‐t‐butyl‐2,3‐dihydro‐1,2,4‐triazin‐5(4H)‐one (3d). The reaction of various 4‐methyl‐1,2,4‐triazin‐5(4H)‐ones with sodium borohydride and the influence of bulkiness and electronic effect of the substituents at the 3‐ and 6‐positions upon the product ratio, are also discussed.
Synthesis and properties of 3‐chloro‐ and 3,7‐dichloro‐3,4‐dihydro‐1‐hydroxycarbostyrils and related heterocyclic compounds
Authors: McCord T. J. , DuBose C. E. , Shafer P. L. , Davis A. L. 
Published: April 2009

Abstract3‐Chloro‐ and 3,7‐dichloro‐3,4‐dihydro‐1‐hydroxycarbostyrils were synthesized by the catalytic hydrogenation of the α‐chloro‐ and α,4‐dichloro‐β‐(o‐nitrophenyl)propionic acids in strong acidic solution over platinum‐on‐carbon sulfided catalyst. However, the catalytic hydrogenation of α‐bromo‐β‐(o‐nitrophenyl)propionic acid yielded 3,4‐dihydro‐1‐hydroxycarbostyril under the same experimental conditions. The 3‐chloro‐3,4‐dihydro‐1‐hydroxycarbostyril and the α‐chloro‐β‐(o‐nitrophenyl)propionic acid underwent facile dehydrochlorination in mild alkaline solution to give 1‐hydroxycarbostyril and o‐nitrocinnamic acid, respectively. Selective reduction of 3‐chloro‐3,4‐dihydro‐1‐hydroxycarbostyril and 1‐hydroxycarbostyril to the corresponding lactams, 3‐chloro‐3,4‐dihydrocarbostyril and carbostyril, was effected by catalytic hydrogenation in hydrochloric acid over platinum black catalyst. The structures of the substituted carbostyril derivatives were correlated with their proton nmr spectra.
Synthesis of fluorinated pyridines by the balz‐schiemann reaction. An alternative route to enoxacin, a new antibacterial pyridonecarboxylic acid
Authors: Matsumoto Jun‐Ichi , Miyamoto Teruyuki , Minamida Akira , Nishimura Yoshiro , Egawa Hiroshi , Nishimura Haruki 
Published: April 2009

AbstractFluorination of the 2,6‐disubstituted 3‐aminopyridines 5 and 12 by the Balz‐Schiemann reaction is described. 2,6‐Dichloro‐3‐pyridinediazonium tetrafluoroborate (6) and 2‐substituted 6‐acetylamino‐3‐pyridinediazonium tetrafluoroborates 13 were heated with or without a solvent to give the corresponding fluorinated pyridines 7 and 14, respectively, in good yields. 2‐Substituted 6‐acetylamino‐3‐fluoropyridines (14) were converted by a known method into a series of 7‐substituted 1‐ethyl‐6‐fluoro‐1,4‐dihydro‐4‐oxo‐1,8‐naphthyridine‐3‐carboxylic acids 21 including enoxacin [1‐ethyl‐6‐fluoro‐1,4‐dihydro‐4‐oxo‐7‐(1‐piperazinyl)‐1,8‐naphthyridine‐3‐carboxylic acid [(2)], a new potential antibacterial agent.
Aminoalkyl derivatives of 2,4′‐bithiazole‐4‐carboxylic acid, the intercalating part of bleomycin
Authors: Houssin Raymond , Bernier Jean‐Luc , Hénichart Jean‐Pierre 
Published: April 2009

AbstractThe synthesis of three 2,4′‐bithiazole derivatives related to the antibiotic antitumor bleomycin is reported. These compounds substituted by aminoalkyl chains on 2′ and/or 4‐positions were prepared by the Hantzs synthesis between new thioamides and methyl 2‐(2‐bromoacetyl)thiazole‐4‐carboxylate and will be useful for the study of the intercalative moiety of bleomycin.
The synthesis of substituted pyrido[1′,2′:1,5]pyrazolo[3,4‐d]pyrimidines
Authors: Molina P. , Arques A. , Hernandez H. 
Published: April 2009

AbstractA convenient synthesis of derivatives of the pyrido[1′,2′:1,5]pyrazolo[3,4‐d]pyrimidine ring system from readily available 2‐amino‐3‐cyano‐5,7‐diphenylpyrazolo[1,5‐a]pyridine I and carbon disulfide, aryl isothiocyanates or nitriles is described. Derivatives of compound I undergo cyclization to the titled ring system by action of dimethylformamide dimethylacetal or hydrogen sulfide followed by treatment with triethylamine.
Synthesis of 1,3,4‐oxadiazaspiro[4.4]nona‐2,6,8‐trienes via 1,3‐dipolar cycloadditions of diphenylnitrilimine with cyclopentadienones. Crystal and molecular structure of a cycloadduct
Authors: Tsatsaroni E. G. , Argyropoulos N. G. , Alexandrou N. E. , Houndas A. , Terzis A. 
Published: April 2009

AbstractThe cycloaddition of diphenylnitrilimine with substituted cyclopentadienones leads to the formation of the title spirooxadiazoline derivatives 2, in good yields. The reaction is examined on the basis of the frontier molecular orbitals of the reacting reagents. An X‐ray crystallographic analysis of the product 2b is made.
The synthesis of lin‐benzoreumycin, lin‐benzo‐1‐methylxanthine, and lin‐benzo‐1,9‐dimethylxanthine
Authors: Schneller Stewart W. , Ibay Augusto C. , Christ William J. 
Published: April 2009

AbstractCommencing with 7‐chloro‐3‐methylquinazoline‐2,4(1H,3H)‐dione (9a), a five step synthesis of 7‐methylpyrimido[5,4‐g]‐1,2,4‐benzotriazine‐6,8(7H,9H)‐dione (lin‐benzoreumycin, 6) has been accomplished. A synthesis of 1,7‐dimethylpyrimido[5,4‐g]‐1,2,4‐benzotriazine‐6,8(1H,7H)‐dione (lin‐benzotoxoflavin, 5) employing an intermediate from the preparation of 6 (i.e., 7‐chloro‐3‐methyl‐6‐nitroquinazoline‐2,4(1H,3H)‐dione, 9b) was attempted but could not be accomplished beyond the dihydro precursor of 5 (i.e., 12). Compound 9b did lead to successful preparations of 7‐methylimidazo[4,5‐g]quinazoline‐6,8(5H,7H)‐dione (lin‐benzo‐1‐methylxanthine, 7) and 3,7‐dimethylimidazo[4,5‐g]quinazoline‐6,8(5H,7H)‐dione (lin‐benzo‐1,9‐dimethylxanthine, 8) by first reacting 9b with ammonia (for 7) or methylamine (for 8) followed by reductive cyclization in formic acid.
Mass spectral fragmentation patterns of heterocycles. VI. Carbazole and 1,8‐dideuteriocarbazole
Authors: Hallberg Anders , Martin Arnold R. 
Published: April 2009

AbstractThe mass spectral fragmentation of carbazole was reinvestigated using metastable ion studies, exact mass measurements and 1,8‐dideuteriocarbazole. 1,8‐Dideuteriocarbazole was prepared by successive metalations and deuterations of carbazole. The 1H‐ and 13C‐nmr spectra of 1,8‐dideuteriocarbazole confirmed earlier assignments for carbazole.
The reaction of substituted thiosemicarbazides and γ‐haloketones
Authors: Jones Winton D. , Kane John M. , Sill Arthur D. 
Published: April 2009

AbstractThe reactions of substituted thiosemicarbazides and γ‐halobutyrophenones afforded derivatives of the tetrahydro‐1H‐pyrrolo[1,2‐b][1,2,4]triazole‐2(3H)‐thione ring system.
N2′‐acetyl‐6‐diacetoxymethylpterin
Authors: Boyle Peter H. , O'Mahony Mary J. 
Published: April 2009

AbstractTreatment of folic acid with bromine in 48% hydrobromic acid gives the hydrobromide salt of 6‐formylpterin (1), and acetylation of 1 with recovered acetic anhydride leads to N2′‐acetyl‐6‐diacetoxymethylpterin (3).
Reaction of 2‐hydrazinoperimidine with acetylacetone
Authors: Liu Kang‐Chien , Chen Hsiu‐Ho 
Published: April 2009

AbstractHeating 2‐hydrazinoperimidine (2) with acetylacetone in absolute ethanol gave exclusively 2‐(3,5‐dimethyl‐1‐pyrazolyl)perimidine (4) via a [2 + 3] cyclization. The possible [4 + 3] condensate, 3,5‐dimethyl‐1H‐1,2,4‐triazepino[4,3‐a]perimidine (5) was not produced. Spectral analyses were applied to the structure elucidation of the products.
The chemistry of 2H‐3,1‐benzoxazine‐2,4(1H)‐dione (isatoic anhydride). 14. A facile entry into the acronycine ring system
Authors: Coppola Gary M. 
Published: April 2009

Abstract6‐Demethoxyacronycine (9), containing the acronycine nucleus, has been readily synthesized in two steps via the reaction of N‐methylisatoic anhydride with the enolate derived from 2,6,7,8‐tetrahydro‐2,2‐dimethyl‐5H‐1‐benzopyran‐5‐one (8) followed by oxidation with DDQ.
Reaction of 2‐acyl‐3‐aminobenzofurans with hydrazines
Authors: Gatta Franco , Settimj Guido 
Published: April 2009

AbstractWhile 2‐acetyl and 2‐benzoyl‐3‐aminobenzofurans did not react with hydrazine, monomethyl‐ and N,N‐dimethylhydrazine to give the related hydrazones, their 3‐N‐(p‐toluenesulfonyl) derivatives afforded them smoothly in good yields. Depending upon reaction conditions, products arising from hydrazone cyclization to benzofuropyrazoles and/or from furan ring cleavage at the C2O bond to give 5‐(2‐hydroxyphenyl)pyrazoles were also formed. The formation of these products depends upon hydrazones configuration and is discussed. Only (E)‐isomers appear to undergo furan ring opening. In acidic media at room temprature either the hydrazones or the monomethylhydrazones gave the same related α‐azines. Microanalyses, ir, uv, 1H‐nmr and ms spectra are in agreement with the proposed structures.
Reactions with 5‐aminopyrazoles. I. Synthesis of halogen‐containing fused pyrazoles
Authors: Hammouda Hamdy A. , El‐Barbary Ahmed A. , Sharaf Mohie A. F. 
Published: April 2009

Abstract5‐Amino‐3‐phenylpyrazole (I) and 5‐amino‐4‐bromo‐3‐phenylpyrazole (II) reacted with ethyl acetoacetate and acetylacetone to give various pyrazolo[1,5‐a]pyrimidines IV‐VI and with benzoins to give different fused pyrazoles, namely, imidazo[1,2‐b]pyrazoles IX, pyrrolo[2,3‐c]pyrazoles X and pyrazolo[4,3‐b][1,4]oxazines XII. Diazotized II was coupled with active methylene‐containing nitriles to afford pyrazolo[5,1‐c]‐as‐triazines XIV.
Studies in spiroheterocycles. Part V. Synthesis of new fluorinated spiro[3H‐indole‐3,2′‐oxiran]‐2(1H)‐ones
Authors: Joshi Krishna C. , Jain Renuka , Garg Saroj 
Published: April 2009

AbstractReinvestigation of the reaction of 3‐aroylmethyleneindol‐2‐ones with hydrogen peroxide has revealed that a 1:1 isomeric mixture of spiro[3H‐indole‐3,2′‐oxiran]‐2(1H)‐ones is formed. The structures of the two isomers have been confirmed by their ir, pmr and mass spectral studies. Mass fragmentation patterns of these compounds are discussed.
Photosensitized oxidation of furans. X. Solvent effect in the nuclear magnetic resonance of functionalized diacyloxiranes
Authors: Graziano M. L. , Mayol L. 
Published: April 2009

AbstractA simple, rapid method to determine the configuration of 2‐alkoxycarbonyl‐2,3‐diacyloxiranes and 2‐alkoxycarbonyl‐2,3‐diacyl‐3‐methyloxiranes is described. The method is based on the observation of the solvent effect on the chemical shifts of the proton or the methyl group linked to the oxirane ring.
Synthesis of some pyrazolo[4,3‐e][1,2]‐ and thiazolo[4,5‐e][1,2]thiazine 1,1‐dioxide derivatives
Authors: Bellemin Robert , Festal Didier 
Published: April 2009

AbstractThe synthesis of various 2‐methylpyrazolo[4,3‐e]‐ and thiazolo[4,5‐e][1,2]thiazine 1,1‐dioxide derivatives is described.
Synthesis of isoquinobenzodiazepinediones
Authors: GÁll‐IstÓk KlÁra , Sterk Lili , TÓth GÁbor , Deák Gyula 
Published: April 2009

Abstract1‐(2′‐Chloroacetylamino)‐4,4‐dimethyl‐1,4‐dihydro‐3(2H)‐isoquinolinone (3) was cyclised by treatment with sodium hydride in dimethyl sulphoxide containing 0.1 % of water to give 10,10‐dimethyl‐6,7,9,10‐tetrahydro‐5H,14bH‐isoquino[2,1‐d][1,4]benzodiazepine‐6,9‐dione (4) in a yield of 80%. In anhydrous dimethyl sulphoxide the main product of the reaction was 5‐N‐(4,4‐dimethyl‐1‐phenyl‐1,4‐dihydro‐3(2H)‐isoquinolinon‐1′‐yl)isoquino[2,1‐d][1,4]benzodiazepine‐6,9‐dione (5), which was also prepared by the reaction of 3 with 4.
Nitrations of acylamino‐ and nitrodibenzo‐p‐dioxins
Authors: Oliver James E. 
Published: April 2009

AbstractNitrations of 1‐ or 2‐acylamino (and nitro) dibenzo‐p‐dioxins were employed to achieve regioselective further functionalization of these compounds. The choice of nitrating conditions and/or acyl substituent (CH3CO vs. CF3CO) often dictated into which ring the first nitro goroup was directed. In almost all cases, nitrations at the 2,3,7,8‐positions were highly favored over nitrations at the 1,4,6,9‐positions; with ammonium nitrate/trifluoroacetic anhydride in tetrahydrofuran, however, nitration of 1‐(trifluoroacetylamino)dibenzo‐p‐dioxin proceeded predominantly at the 4‐position.
v‐Triazolines. Part XIX. Thiocino[4,5‐d]‐1,2,3‐triazole and thiocino[4,5‐d]isoxazole derivatives
Authors: Almirante Nicoletta , Forti Luciana 
Published: April 2009

Abstract5‐Amino‐2,3,6,7‐tetrahydrothiocines were reacted with arylazides yielding 1‐aryl‐9a‐amino‐1,3a,4,5,7,8,9,9a‐octahydrothiocino[4,5‐d]‐1,2,3‐triazoles which could be deaminated to 1‐aryl‐1,4,5,7,8,9‐hexahydrothiocino‐[4,5‐d]‐1,2,3‐triazoles. Similarly, the above enamines yielded, with nitrile oxides, 3‐aryl‐9a‐amino‐3a,4,5,8,9,9a‐hexahydrothiocino[4,5‐d]isoxazoles which were transformed with acids into 3‐aril‐4,5,8,9‐tetrahydrothiocino‐[4,5‐d]isoxazoles.
The stereochemistry of 4,8‐dimethyl‐6‐phenyl‐5,6,7,8‐tetrahydro‐4H‐1,3,6‐dioxazocin‐2‐ones using NMR
Authors: Nishiyama Tomihiro , Ikemoto Etsuo , Yamada Fukiko 
Published: April 2009

AbstractTwo isomeric 4,8‐dimethyl‐6‐phenyl‐5,6,7,8‐tetrahydro‐4H‐1,3,6‐dioxazocin‐2‐ones were prepared, and their pmr and cmr spectra were examined. From the tris(dipivaloylmethanato) europium (Eu(dpm)3) shift reagent and the dihedral angle, the title compounds are found to exist in the eq‐ax and eq‐eq methyl groups with boat‐chair form.
Stereochemical assignments of the 6‐phenyl‐2‐oxabicyclo[3.1.0]hexanes
Authors: Schaub Lowry P. , Woodyard James D. 
Published: April 2009

AbstractPreparation and stereochemical assignments of the 6‐phenyl‐2‐oxabicyclo[3.1.0]hexanes are reported. The stereochemical assignments are based on chemical as well as nmr data.
Synthesis of some new mesoionic heterocycles
Authors: Taneja Vineeta , Anand Madhu , Gupta C. L. , Gupta S. B. , Mital R. L. 
Published: April 2009

AbstractThe synthesis of various substituted 1‐hydroxy‐2‐chloroacetyl‐6‐thia‐10b‐aza‐2a‐azoniaaceanthrylene hydroxide inner salt, 1‐hydroxy‐6‐thia‐10b‐aza‐2a‐azoniaaceanthrylene hydroxide inner salt, 1‐hydroxy‐2‐piperidinoacetyl‐6‐thia‐10b‐aza‐2a‐azoniaaceanthrylene hydroxide inner salt is described. The ir is also included.
The reactivity of 4‐hydroxy‐6‐methyl‐2‐pyrone towards different types of ketones
Authors: De March P. , Roca J. L. , Moreno‐Mañas M. , Pleixats R. 
Published: April 2009

Abstract4‐Hydroxy‐6‐methyl‐2‐pyrone (triacetic acid lactone) reacts at C‐3 with acetone, mesityl oxide and pentane‐2,4‐dione. The structures of the final products have been elucidated.
Reactions of 1,3‐thiazine‐2,6‐dithiones. Part 5. Novel synthesis of 3,5‐dicyano‐4‐thiopyridones via 2‐cyanomethyldihydro‐1,3‐thiazine‐6‐thiones
Authors: Muraoka Motomu , Yamamoto Tatsuo 
Published: April 2009

AbstractA novel synthesis of a series of 2,6‐disubstituted 3,5‐dicyano‐4‐thiopyridones 4 by the decomposition of 2,4‐disubstituted 5‐cyano‐2‐cyanomethyldihydro‐1,3‐thiazine‐6‐thiones 2, which are synthesized from 4‐substituted 5‐cyano‐1,3‐thiazine‐2,6‐dithiones and enaminonitriles, is described.
Derivatives of benzo[4,5]cyclohepta[1,2‐b]thiophene 3. Synthesis of 2,3,6,7‐tetrahydro‐3‐oxobenzo[1,2]cyclohepta[3,4,5‐hi]thieno[3,4‐c]pyridine and 2,3,7,8‐tetrahydro‐3‐oxothieno[2,1‐b]cyclohepta[5,6,7‐de]isoquinoline
Authors: Arribas Enrique , Vega Salvador 
Published: April 2009

AbstractThe title compounds 3 and 4 were synthesized by cyclization via isocyanate of the Z and E‐9,10‐dihydro‐4H‐benzo[4,5]cyclohepta[1,2‐b]thiophene‐4‐ylidenacetic acids 8 and 9, which in turn were prepared by the Wadsworth‐Emmons reaction of ketone 5 with triethyl phosphonacetate followed by separation and independent hydrolysis of the corresponding esters 6 and 7. The structures of these new compounds as well as the configurations of their isomeric precursors are described.
13C NMR spectral assignments of chlorpromazine and its 5‐oxide. Literature correction
Authors: Jovanovic Misa V. , Biehl E. R. 
Published: April 2009

AbstractThe 13C chemical shift assignments of title compounds were made on the basis of their coupled and decoupled spectra. The size of the ipso and allylic 13CH coupling constants establish unequivocally the identity of symmetry related carbon pairs and show that several assignments reported previously are incorrect.
Reaction of chlorosulfonyl isocyanate with aziridines
Authors: Murthy K. S. Keshava , Dhar D. N. 
Published: April 2009

AbstractThe reaction of chlorosulfonyl isocyanate (CSI) with 1,2,3‐triphenylaziridine (1) and some cis‐ and trans‐1‐cyclohexyl‐2‐aroyl‐3‐phenylaziridines, 4‐7 and 19‐22 has been described. The cis‐isomers of aziridines, 4‐7, undergo a smooth reaction with CSI to give the corresponding cis‐isomers of 2‐chlorosulfonylimino‐1,3‐oxazolidines, 8‐11, in good yields (65‐67%). While the trans‐isomers, 19‐22, gave unusual products 23‐26 which have been assigned a bicyclic structure, based on their physical and spectral (ir, pmr, ms) data. Plausible mechanisms have been postulated to explain the transformations.
Functionalization of substituted 2(1H)‐pyridones. V. The synthesis of 1,2‐dihydro‐2‐oxo‐3,5‐pyridinedicarboxylic acid derivatives through a novel dianion route
Authors: Domagala John M. 
Published: April 2009

AbstractA new pyridone dianion was prepared by halogen‐metal exchange from 5‐bromo‐1,2‐dihydro‐2‐oxo‐3‐pyrid‐inecarboxylic acid, t‐butyl ester and two equivalents of n‐butyllithium. This 1,5‐dianion readily reacted at C5 with electrophiles. Quenching with carbon dioxide gave the previously unreported 1,2‐dihydro‐2‐oxo‐3,5‐pyridine dicarboxylic acid, 3‐t‐butyl ester. The 5‐carboxyl groups were selectively converted to the ethyl ester and the ethyl amide through the 5‐imidazolide. The 3‐t‐butyl ester was easily removed from all derivatives with acid hydrolysis.
The synthesis of some derivatives of benzo[f]naphtho[1,8‐bc]thiepin‐12‐one
Authors: Flores Maria Celia , Beller Nicholas R. , Castrillón JosÉ 
Published: April 2009

AbstractThe preparations of benzo[f]naphtho[1,8‐bc]thiepin‐12‐one, its 6‐methyl and 6‐methoxy derivatives and their corresponding sulfoxides and sulfones are described. They involve the coupling of suitable halogen naphthyl derivatives with thiophenoxides with the help of copper and the cyclization of the resulting acids with phosphorus pentoxide in benzene. The oxidations to sulfoxides and sulfones were performed with iodo‐benzene diacetate and hydrogen peroxide, respectively. The ir and pmr spectra are reported.
Synthèse de dérivés du tétrathiafulvalène à propriétés mésomorphogènes
Authors: Polycarpe Catherine , Torreilles Eliane , Giral Louis , Babeau Annick , Tinh Nguyen‐Hun , Gasparoux Henri 
Published: April 2009

AbstractNous décrivons la synthèse de bis (alkyl‐4 phényl) et bis (alkoxy‐4 phényl) tétrathiafulvalènes originaux. Certains d'entre eux présentent un polymorphisme dont on a précisé les températures de transition.
The synthesis of propellance compounds from 2,3‐disubsituted indoles and o‐benzoquinones
Authors: Omote Yoshimori , Harada Kazuo , Tomotake Atsushi , Kashima Choji 
Published: April 2009

AbstractThe reaction of 2,3‐dihydro‐1H‐cyclopent[b]indole 3 and 1,2,3,4‐tetrahydrocarbazole 4 with substituted o‐benzoquinones yielded [4.3.3]‐ and [4.4.3]propellanes, respectively. The physical and chemical properties of the propellane compounds were investigated and a mechanism for the formation of the propellane compounds was discussed.