bluuebunny/crossref_metadata_2025_split huggingface dataset:
Long-term survival following delayed presentation and resection of colorectal liver metastases
Authors: Swan P J , Welsh F K S , Chandrakumaran K , Rees M 
Published: May 2011

Abstract

Background
Long-term survival from metastatic colorectal cancer is partly dependent on favourable tumour biology. Large case series have shown improved survival following hepatectomy for colorectal liver metastases (CRLM) in patients diagnosed with metastases more than 12 months after index colorectal surgery (metachronous), compared with those with synchronous metastases. This study investigated whether delayed hepatic resection for CRLM affects long-term survival.

Methods
Consecutive patients undergoing hepatic resection for CRLM in a single centre (1987–2007) were grouped according to the timing of hepatectomy relative to index bowel surgery: less than 12 months (synchronous; group 1), 12–36 months (group 2) and more than 36 months (group 3). Cancer-specific survival was calculated using Kaplan–Meier analysis.

Results
There were 577 patients (48·0 per cent) in group 1, 467 (38·9 per cent) in group 2 and 158 (13·1 per cent) in group 3. The overall 5-year cancer-specific survival rate after liver surgery was 42·3 per cent, with no difference between groups. However, when measured from the time of primary colorectal surgery, group 3 showed a survival advantage at both 5 and 10 years (94·1 and 47·6 per cent respectively) compared with groups 1 (46·3 and 24·9 per cent) and 2 (57·1 and 35·0 per cent) (P = 0·003). Survival graphs showed a steeper negative gradient from 5 to 10 years for group 3 compared with groups 1 and 2 (−0·80 versus − 0·34 and − 0·37), indicating an accelerated mortality rate.

Conclusion
Patients undergoing delayed liver resection for CRLM have a survival advantage that is lost during long-term follow-up.
Detection and identification of diterpenoid alkaloids, isoflavonoids and saponins in Qifu decoction and rat plasma by liquid chromatography–time‐of‐flight mass spectrometry
Authors: Tan Guangguo , Jing Jing , Zhu Zhenyu , Lou Ziyang , Li Wuhong , Zhao Liang , Zhang Guoqing , Chai Yifeng 
Published: May 2011

ABSTRACTA liquid chromatography–time‐of‐flight mass spectrometric (LC‐TOFMS) method has been developed for analysis of components in Qifu decoction (QFD), a traditional Chinese medical formula consisting of Radix Astragali and Acontium carmichaeli, and in rat plasma after oral administration. Based on accurate mass measurements within 3 ppm error for each molecular ion and subsequent fragment ions of TOFMS, as well as matching of empirical molecular formulae with those of published components in the in‐house chemical library, a total of 44 major components including 21 diterpenoid alkaloids, 12 flavonoids and 11 saponins were identified in QFD. After oral administration of QFD, 22 components in rat plasma were detected and identified by comparing and contrasting the constituents measured in QFD with those in the plasma samples. The results provided valuable chemical information for further pharmacology and active mechanism research on QFD. LC‐TOFMS was also applied for the comparison of relative peak area of major active components between QFD and the single herb extracts. The concentration ratios of major saponins detected in the crude herb Radix Astragali were found to be different from those in QFD. The experimental data indicated that the decocting process could result in differences in the amounts of active components. Copyright © 2011 John Wiley & Sons, Ltd.
Determination of daumone in mouse plasma by HPLC/MS‐MS
Authors: Noh Keumhan , Park Jong Hee , Kim Minkyu , Jung Mankil , Lee Hwa Jeong , Kwon Kwang‐il , Kang Wonku , Ha Hunjoo 
Published: May 2011

ABSTRACTDaumone, a pheromone secreted by Caenorhabditis elegans, is an essential regulator of chemosensory processes in development and aging. A quantification method using HPLC/MS‐MS was developed for the determination of daumone in mouse plasma. After simple protein precipitation with acetonitrile including methaqualone (an internal standard), the analytes were chromatographed on a reversed‐phase column and detected by liquid chromatography/tandem mass spectrometry with electrospray ionization. The accuracy and precision of the assay were in accordance with FDA regulations for validation of bioanalytical methods. This method was applied to measure the plasma daumone concentrations following a 5‐week repeated oral administration of daumone in mice. Copyright © 2011 John Wiley & Sons, Ltd.
Highly sensitive method for the determination of JI‐101, a multi‐kinase inhibitor in human plasma and urine by LC‐MS/MS‐ESI: method validation and application to a clinical pharmacokinetic study
Authors: Sharma Sandeep , Dubey Naveen Kumar , Dasgupta Ashish K. , Sahu Monashis , Benjamin Biju , Mullangi Ramesh , Srinivas Nuggehally R. 
Published: May 2011

ABSTRACTA highly sensitive, rapid assay method has been developed and validated for the estimation of JI‐101 in human plasma and urine using LC‐MS/MS‐ESI in the positive‐ion mode. The assay procedure involves extraction of JI‐101 and alfuzosin (internal standard, IS) from human plasma/urine with a solid‐phase extraction process. Chromatographic resolution was achieved on two Zorbax SB‐C18 columns connected in series with a PEEK coupler using an isocratic mobile phase comprising acetonitrile–0.1% formic acid in water (70:30, v/v). The total run time was 2.0 min. The MS/MS ion transitions monitored were 466.20 → 265.10 for JI‐101 and 390.40 → 156.10 for IS. The method was subjected to rigorous validation procedures to cover the following: selectivity, sensitivity, matrix effect, recovery, precision, accuracy, stability and dilution effect. In both matrices the lower limit of quantitation was 10.0 ng/mL and the linearity range extended from ~10.0 to 1508 ng/mL in plasma or urine. The intra‐ and inter‐day precisions were in the ranges 1.57–14.5 and 6.02–12.4% in plasma and 0.97–15.7 and 8.66–10.2% in urine. This method has been successfully applied for the characterization of JI‐101 pharmacokinetics in cancer patients. Copyright © 2011 John Wiley & Sons, Ltd.
Construction of a light‐emitting diode fluorescence detector for high‐performance liquid chromatography and its application to fluorometric determination of l‐3‐hydroxybutyrate
Authors: Chen Chien‐Ming , Lee Jen‐Ai , Huang Tzu‐Chuan 
Published: May 2011

ABSTRACTThis study employed a new light source, a light‐emitting diode (LED), for fluorescence detection of high‐performance liquid chromatography to measure the concentration of trace constituents in biological fluids. Using l‐3‐hydroxybutyrate ( l‐3HB) as a tested trace compound, the function of the new system was compared with that of the current commercially available model. A detailed schematic diagram of the path of the detection rays in the LED detector is given. A voltage‐stabilizer for the drive circuit was designed with an input of 10 V and an output of 8 V, and another voltage regulator was used to maintain a constant 8 V. Then the regulator was used to set the output voltage for the LED at 2.8 V by two external resistors. Replacing the xenon lamp with LED, this system provided higher photon density and a narrow spectrum at a wavelength of 491 nm. At room temperature (22.1°C), the average temperature of six places in the chamber of LED detector was 22.1°C compared with 51.1°C in the xenon detector. The spectra of the excitation light sources were measured. Compared with the xenon lamp, approximately 1.32 times higher excitation intensity was obtained by the LED source. The accuracy of detection of l‐3HB in 50 μL of rat serum was 99.85–100.85%, and the intra‐day and inter‐day precision values were within 8.99 and 13.90%, respectively. The limit of detection of l‐3HB was approximately 0.73 µM (signal‐to‐noise ratio 3). The sensitivity of the proposed LED detector was comparable to that of traditional fluorescence detectors using xenon arc lamps; however, the cost and operating temperature of LED lamps were far lower. This assay system could be further used to detect trace constituents in various samples. Copyright © 2011 John Wiley & Sons, Ltd.
Global hip‐hop identities: Black youth, psychoanalytic action research, and the Moving to the Beat project
Authors: Haaken Janice , Wallin‐Ruschman Jennifer , Patange Simona 
Published: May 2011

ABSTRACTThe paper presents a psychoanalytically informed analysis of the concept of hip‐hop identity through the lens of a four‐year social action research and documentary film project, titled Moving to the Beat (M2B). The M2B project sought to document and unpack key psychological and social dynamics behind the struggle for a global identity among Black hip‐hop activists in Africa and America. Two groups were formed, one in Portland, Oregon and a second in Freetown, Sierra Leone, with the aim of enlisting hip‐hop as a mode of cross‐cultural dialogue and as a forum for activism. Three key themes are discussed as they emerged as sites of creative conflict through the M2B project: the struggle to establish a progressive identity over against politically and psychologically regressive currents in hip‐hop culture, the search for authenticity in the context of globally manufactured identities, and differing conceptions of rebellion and intergenerational conflict. The paper describes how psychoanalytic theory informed the process of producing the Moving to the Beat documentary film and working through these sites of conflict in negotiating the borders of hip‐hop global identities. Copyright © 2011 John Wiley & Sons, Ltd.
Autotransporters with GDSL Passenger Domains: Molecular Physiology and Biotechnological Applications
Authors: Wilhelm Susanne , Rosenau Frank , Kolmar Harald , Jaeger Karl‐Erich 
Published: May 2011

AbstractAutotransporters are large proteins produced and secreted by Gram‐negative bacteria. They consist of an N‐terminal passenger domain, which typically harbours enzymatic activity and exerts a virulence function, and a C‐terminal membrane anchor domain. Somehow, the membrane domain facilitates the transport of the passenger domain into the extracellular space. Several autotransporters possess hydrolase passenger domains that belong to the GDSL family of lipolytic enzymes. GDSL autotransporters represent a functionally distinct family and are characterized by several features of their passenger domains; these include 1) the absence of a conserved right‐handed parallel β‐helix, 2) lipolytic activity, and thus the capability to hydrolyse membranes, and 3) covalent attachment to the respective C‐terminal β‐domain, with the hydrolase domain exposed to the exterior. The esterase EstA of Pseudomonas aeruginosa is a typical enzyme of this type. Its physiological role was studied, its potential biotechnological application has been demonstrated, and its crystal structure was solved recently. Furthermore, it is capable of displaying different classes of enzymes in a range of Gram‐negative bacteria including Escherichia coli, and FACS‐based high‐throughput screening for enantioselective esterases could be achieved using EstA.
A Homogeneous Mixture Composed of Vanadate, Acid, and TEMPO Functionalized Ionic Liquids for Alcohol Oxidation by H2O2
Authors: Wang Sa‐Sa , Popović Zora , Wu Hai‐Hong , Liu Ye 
Published: May 2011

AbstractThe functionalized ionic liquids (ILs) of N‐n‐dodecyl pyridinium vanadate (1), N‐(propyl‐1‐sulfonic acid) pyridinium tetrafluoroborate (2), and 4‐(propanoate‐2,2,6,6,‐tetramethylpiperidine‐1‐oxyl) pyridinium tetrafluoroborate (5) were synthesized. The mixture of 1, 2, and 5 in [Bpy]BF4 yielded the compatible IL compositions (ILCs) as a homogenous mixture, which proved to be an efficient catalytic system for oxidation of a wide range of alcohols using H2O2. With the aid of 2 and 5, 1 in [Bpy]BF4 could easily be recovered and reused for at least six runs without a loss in activity. UV/Vis spectroscopic analysis indicated that the role of 2 was to promote the formation of the active peroxo VV species, which is responsible for substrate activation, and the role of 5 was to oxidize the low‐valent vanadium(II–IV) species to regenerate 1.
Chiral Donor Photoinduced‐Electron‐Transfer (d‐PET) Boronic Acid Chemosensors for the Selective Recognition of Tartaric Acids, Disaccharides, and Ginsenosides
Authors: Wu Yubo , Guo Huimin , Zhang Xin , James Tony D. , Zhao Jianzhang 
Published: May 2011

AbstractA modular approach was proposed for the preparation of chiral fluorescent molecular sensors, in which the fluorophore, scaffold, and chirogenic center can be connected by ethynyl groups, and these modules can easily be changed to other structures to optimize the molecular sensing performance of the sensors. This modular strategy to assembly chiral sensors alleviated the previous restrictions of chiral boronic acid sensors, for which the chirogenic center, fluorophore, and scaffold were integrated, thus it was difficult to optimize the molecular structures by chemical modifications. We demonstrated the potential of our new strategy by the preparation of a sensor with a larger scaffold. The photoinduced electron‐transfer (PET) effect is efficient even with a large distance between the N atom and the fluorophore core. Furthermore, the rarely reported donor‐PET (d‐PET) effect, which was previously limited to carbazole, was extended to phenothiazine fluorophore. The contrast ratio, that is, PET efficiency of the new d‐PET sensor, is increased to 8.0, compared to 2.0 with the previous carbazole d‐PET sensors. Furthermore, the ethynylated phenothiazine shows longer excitation wavelength (centered at 380 nm) and emission wavelength (492 nm), a large Stokes shift (142 nm), and high fluorescence quantum yield in aqueous solution (Φ=0.48 in MeOH/water, 3:1 v/v). Enantioselective recognition of tartaric acid was achieved with the new d‐PET boronic acid sensors. The enantioselectivity is up to 10 (ratio of the binding constants toward D‐ and L‐tartaric acid, kD/kL). A consecutive fluorescence enhancement/decrease was observed, thus we propose a transition of the binding stoichiometry from 1:1 to 1:2 as the analyte concentration increases, which is supported by mass spectra analysis. The boronic acid sensors were used for selective and sensitive recognition of disaccharides and glycosylated steroids (ginsenosides).
ChemInform Abstract: Bismuth Flux Crystal Growth of LnRh6P4 (Ln: Sc, Yb, Lu): New Phosphides with a Superstructure of the LiCo6P4 Type.
Authors: Pfannenschmidt Ulrike , Rodewald Ute Ch. , Poettgen Rainer 
Published: May 2011

AbstractSingle crystals of the title compounds are prepared from the elements in a Bi flux (silica tubes, 1320 K, 100 h).
ChemInform Abstract: Luminescent Properties of Orange‐Emitting Long‐Lasting Phosphorescence Phosphor Ca2SnO4:Sm3+.
Authors: Lei Bingfu , Zhang Haoran , Mai Wenjie , Yue Song , Liu Yingliang , Man Shi‐qing 
Published: May 2011

AbstractThe new orange‐emitting title phosphor is synthesized by solid state reaction of stoichiometric mixtures of CaCO3, SnO2, and Sm2O3 (air, alumina crucible, 1400 °C, 4 h) and characterized by powder XRD and photoluminescence spectroscopy.
ChemInform Abstract: Low‐Platinum‐Content Quaternary PtCuCoNi Nanotubes with Markedly Enhanced Oxygen Reduction Activity.
Authors: Liu Lifeng , Pippel Eckhard 
Published: May 2011

AbstractPt5Cu76Co11Ni8 nanotubes are prepared by a highly efficient template‐assisted one‐step electrodeposition method using a solution of KPtCl6, CuCl2, CoCl2, NiCl2, and H3BO3 as electrolyte.
ChemInform Abstract: Exhaustive Chlorination of [B12H12]2‐ Without Chlorine Gas and the Use of [B12Cl12]2‐ as a Supporting Anion in Catalytic Hydrodefluorination of Aliphatic C—F Bonds.
Authors: Gu Weixing , Ozerov Oleg V. 
Published: May 2011

AbstractThe fully chlorinated closo‐dodecaborate anion is successfully prepared using SO2Cl2 instead of the more hazardous and expensive chlorine gas.
ChemInform Abstract: A Gallogermanate Zeolite Constructed Exclusively by Three‐Ring Building Units.
Authors: Han Yide , Li Yi , Yu Jihong , Xu Ruren 
Published: May 2011

Abstract[Ni(en)3][Ga2Ge4O12] is solvothermally synthesized from a mixture of GeO2, GaOOH, [Ni(en)3]Cl2, HF, en, ethanolamine, and H2O (autoclave, 180 °C, 8 d).
ChemInform Abstract: Ba3 [Ge2B7O16(OH)2] (OH)(H2O) and Ba3Ge2B6O16: Novel Alkaline‐Earth Borogermanates Based on Two Types of Polymeric Borate Units and GeO4 Tetrahedra.
Authors: Zhang Jian‐Han , Kong Fang , Mao Jiang‐Gao 
Published: May 2011

AbstractThe structures of the new title compounds (IV) (trigonal, space group P$\bar 1$, Z = 1) and (V) (monoclinic, Cc, Z = 4) are determined by single crystal XRD.
ChemInform Abstract: Crystal Structures and Conductivities of Two Organic—Inorganic Hybrid Complexes Based on Poly‐Keggin‐Anion Chains.
Authors: Wei Mei‐Lin , Zhuang Peng‐Fei , Li Hui‐Hua , Yang Yun‐Hui 
Published: May 2011

AbstractCompounds (IIIa) and (IIIb) crystallize in the orthorhombic space group Pnnm with Z = 2 (single crystal XRD) and exhibit exactly the same three‐dimensional supramolecular framework built from non‐covalent interactions between isonicotinic acid N‐oxide (HINO) molecules, [M(H2O)8]2+ and H+(H2O)2.5 clusters, and [PMo12O40]3‐ anions which self‐assemble into poly‐Keggin‐anion chains.
ChemInform Abstract: P22‐ and P3‐ Units in the [Rh8P9]δ‐ Polyanion of La4Rh8P9.
Authors: Pfannenschmidt Ulrike , Johrendt Dirk , Behrends Frederick , Eckert Hellmut , Eul Matthias , Poettgen Rainer 
Published: May 2011

AbstractPillar‐shaped single crystals of the new title compound are obtained from a stoichiometric mixture of the elements in a Bi flux (evacuated silica tube, 1.
ChemInform Abstract: Facile and Efficient Hydrolysis of Organic Halides, Epoxides, and Esters with Water Catalyzed by Ferric Sulfate in a PEG1000‐DAIL[BF4]/Toluene Temperature‐Dependent Biphasic System.
Authors: Hu Yu Lin , Jiang Hui , Zhu Jie , Lu Ming 
Published: May 2011

AbstractThe use of a temperature‐dependent biphasic system offers an efficient, experimentally simple, and environmentally friendly protocol for the hydrolysis of organic halides, epoxides, and esters.
ChemInform Abstract: Reaction of Unsaturated Compounds with Ethyl Benzenesulfenate and Trimethylsilyl Isothiocyanate.
Authors: Zyk N. V. , Gavrilova A. Yu. , Mukhina O. A. , Borisenko A. A. , Bondarenko O. B. , Zefirov N. S. 
Published: May 2011

AbstractThe regio‐ and stereoselectivities of reactions of alkenes, dienes, and alkynes with ethyl benzenesulfenate (II) and trimethylsilyl isothiocyanate (III) are studied.
ChemInform Abstract: Palladium‐Catalyzed Carboiodination of Alkenes: Carbon—Carbon Bond Formation with Retention of Reactive Functionality.
Authors: Newman Stephen , Lautens Mark 
Published: May 2011

AbstractThe intramolecular carboiodination reaction between an aryl iodide and an alkene moiety proceeds in the presence of a palladium(0) catalyst bearing the exceptionally bulky Q‐phos ligand to give benzo‐fused 5‐ and 6‐membered ring products.
ChemInform Abstract: Enantiomerically Pure 2‐Aryl(alkyl)‐2‐trifluoromethylaziridines: Synthesis and Ring Opening with Selected O‐ and N‐Nucleophiles.
Authors: Grellopois Fabienne , Nonnemacher Jean , Lachaud Fabien , Portella Charles 
Published: May 2011

AbstractUnder basic conditions, N‐tosyl aziridines are regioselectively opened at the less hindered carbon.
ChemInform Abstract: Effects of Haloniums on Gold‐Catalyzed Ring Expansion of 1‐Oxiranyl‐1‐alkynylcyclopropanes.
Authors: Liao Hsuan‐Hung , Liu Rai‐Shung 
Published: May 2011

AbstractDistinct chemoselectivities are observed for the Au‐catalyzed transformation of the title compounds into halogenated products in the presence of N‐halosuccinimides under Au catalysis.
ChemInform Abstract: A Dinuclear Palladium Catalyst for α‐Hydroxylation of Carbonyls with O2.
Authors: Chuang Gary Jing , Wang Weike , Lee Eunsung , Ritter Tobias 
Published: May 2011

AbstractThe paddle‐wheel complex (I) is a chemo‐ and regioselective catalyst for the hydroxylation of a variety of carbonyl compounds at the α‐position to afford tertiary alcohols.
ChemInform Abstract: Thionations Using a P4S10—Pyridine Complex in Solvents such as Acetonitrile and Dimethyl Sulfone.
Authors: Bergman Jan , Pettersson Birgitta , Hasimbegovic Vedran , Svensson Per H. 
Published: May 2011

AbstractThe compound (II) is an efficient thionation reagent which exhibits good solubility and thermal stability and allows formation of a wide range of thiones.
ChemInform Abstract: Asymmetric Crossed‐Conjugate Addition of Nitroalkenes to Enones by a Chiral Bifunctional Diamine Organocatalyst.
Authors: Wang Min , Lin Lili , Shi Jian , Liu Xiaohua , Kuang Yulong , Feng Xiaoming 
Published: May 2011

AbstractAn easily available new type of primary‐secondary diamine catalyst promotes the title reaction with yields of up to 96% and enantioselectivities of up to 99% e.e.
ChemInform Abstract: Transesterification Catalyzed by Iron(III) β‐Diketonate Species.
Authors: Weng Shiue‐Shien , Ke Chih‐Shueh , Chen Fong‐Kuang , Lyu You‐Fu , Lin Guan‐Ying 
Published: May 2011

AbstractThe reaction is applied to a wide range of carboxylic esters and alcohols tolerating many functional groups.Benzyl thiol as a nucleophile requires 2 equiv.
ChemInform Abstract: Diarylprolinol in the Direct Asymmetric Aldol Reaction of Trifluoromethylacetaldehyde Ethyl Hemiacetal with Aldehyde.
Authors: Hayashi Yujiro , Yasui Yusuke , Kawamura Tsuyoshi , Kojima Masahiro , Ishikawa Hayato 
Published: May 2011

AbstractThe reaction proceeds with moderate diastereoselectivity and high enantioselectivity.
ChemInform Abstract: Carbon—Sulfur Bond Formation via Iridium‐Catalyzed Asymmetric Allylation of Aliphatic Thiols.
Authors: Gao Ning , Zheng Shengcai , Yang Weikang , Zhao Xiaoming 
Published: May 2011

AbstractThe reaction allows highly regio‐ and enantioselective formation of α‐branched allyl alkyl sulfides.
ChemInform Abstract: Lewis Acid Activated Synthesis of Highly Substituted Cyclopentanes by the N‐Heterocyclic Carbene Catalyzed Addition of Homoenolate Equivalents to Unsaturated Ketoesters.
Authors: Cohen Daniel T. , Cardinal‐David Benoit , Scheidt Karl A. 
Published: May 2011

AbstractThe use of Ti(O‐Pr)4 as a mild Lewis acid in combination with NHC catalysis is essential for the activation of α,β‐unsaturated aldehydes and promotion of the conjugate addition to ketoesters.
ChemInform Abstract: Highly Enantioselective and Regioselective Copper‐Catalyzed 1,4 Addition of Grignard Reagents to Cyclic Enynones.
Authors: Tissot Matthieu , Perrez Hernandez Alexandra , Mueller Daniel , Mauduit Marc , Alexakis Alexandre 
Published: May 2011

AbstractThe reaction of (I) and (VII) with Grignard reagents results in regio‐ and enantioselective formation of 1,4‐adducts.
ChemInform Abstract: Pd‐Catalyzed Desulfitative Heck Coupling with Dioxygen as the Terminal Oxidant.
Authors: Zhou Xianya , Luo Jiaying , Liu Jing , Peng Shengming , Deng Guo‐Jun 
Published: May 2011

AbstractCompared to CO2 (<150°C), SO2 is already eliminated at 85°C.
ChemInform Abstract: Alternative Method for the Reduction of Aromatic Nitro to Amine Using TMDS‐Iron Catalyst System.
Authors: Pehlivan Leyla , Metay Estelle , Laval Stephane , Dayoub Wissam , Demonchaux Patrice , Mignani Gerard , Lemaire Marc 
Published: May 2011

AbstractThe reduction proceeds generally with good selectivity and tolerates various functional groups.
ChemInform Abstract: Access to High Levels of Molecular Complexity by One‐Pot Iridium/Enamine Asymmetric Catalysis.
Authors: Quintard Adrien , Alexakis Alexandre , Mazet Clement 
Published: May 2011

AbstractA sequence is developed through isomerization (alcohol ‐< aldehyde) in the presence of a chiral Ir‐catalyst followed by α‐substitution in the presence of a chiral organocatalyst.
ChemInform Abstract: An Efficient Method for Synthesis of Phenacyl Derivatives under Homogeneous Phase Transfer Catalyst Condition in Aqueous Media.
Authors: Sayyahi Soheil , Saghanezhad Jafar 
Published: May 2011

Abstractα‐Bromo acetophenones (I) undergo substitution reactions with nucleophiles in the presence of Bu4NBr in water to provide the corresponding azide, thiocyanate, iodide, and cyanide derivatives.