bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluation of a multi‐line broiler chicken population using a single‐step genomic evaluation procedure
Authors: Simeone R. , Misztal I. , Aguilar I. , Vitezica Z.G. 
Published: July 2011

SummaryEffects on prediction of analysing a multi‐line chicken population as one line were evaluated. Body weight records were provided by Cobb‐Vantress for two lines of broiler chickens. Phenotypic records for 183 695 and 164 149 broilers and genotypic records for 3195 and 3001 broilers were available for each line. Lines were combined to create a multi‐line population and analysed using a single‐step procedure combining the additive relationship matrix and the genomic relationship matrix (G). G was scaled using allele frequencies from each line, the multi‐line population, or 0.5. When allele frequencies were calculated from each line, distributions of diagonal elements were bimodal. When allele frequencies were calculated from the multi‐line population, the distribution of diagonal elements had one peak. When allele frequency 0.5 was used, the distribution was bimodal. Genomic estimated breeding values (GEBVs) were predicted using each allele frequency. GEBVs differed with allele frequency but had ≥0.99 correlations with GEBVs predicted with correct allele frequencies. Means of each line and differences in mean between the lines differed based on allele frequencies. Assumed allele frequencies have little impact on ranking within line but larger impact on ranking across lines. G may be used to evaluate multiple populations simultaneously but must be adjusted to obtain properly scaled estimates when population structure is unknown.
Rediscovering nursing: A study of overseas nurses working in Western Australia
Authors: Smith Christine D. A. , Fisher Colleen , Mercer Annette 
Published: July 2011

AbstractThe shortage of nurses worldwide has taken its toll on the Australian healthcare system and, as a result, there is an increased migration of overseas‐qualified nurses, some of them with a non‐English‐speaking background. Despite Australia's regulations that assess the eligibility for nursing registration, many migrant nurses who have been successful in gaining their nursing license feel only partially prepared to work. This article presents the findings of a study, based on Husserlian phenomenology, that describes the work experience of 13 female nurses who were working in Western Australia, Australia. The participants, who could recognize the core components of nursing, were taken aback by the way that nursing is practised in Western Australia. The major differences that they encountered were related to clinical skills, holistic care, the work dynamic with doctors and patients, and the overall societal status of the nursing profession. As a result, they had to adjust their practice to conform to the new work environment. In this study, the participants elaborated on some positive and some not‐so‐positive aspects of their experiences in their endeavor to integrate into the Western Australian metropolitan hospital setting.
Subarachnoid hemorrhage in elderly: Advantages of the endovascular treatment
Authors: Garbossa Diego , Panciani Pier Paolo , Fornaro Riccardo , Crobeddu Emanuela , Marengo Nicola , Fronda Chiara , Ducati Alessandro , Bergui Mauro , Fontanella Marco 
Published: July 2011

Aim:  Subarachnoid hemorrhage (SAH) from aneurysm rupture accounts for approximately 3% of all strokes. A significant improvement in surgery and endovascular procedures has reduced mortality and morbidity. Nowadays, endovascular treatment is a viable alternative to conservative treatment in elderly patients. We designed a retrospective observational study on all endovascular procedures carried out in our department in order to evaluate the outcome in elderly patients compared with a younger cohort.Methods:  A total of 378 patients with aneurysmal SAH were treated with detachable platinum coils in our department (1994–2009). Of these, 310 patients were aged 20–69 years and 68 were aged over 70 years. Data were stratified according to Hunt–Hess (H–H) grade at admission. The mean follow up was 4.8 years. The final outcome was evaluated through the Glasgow Outcome Scale (GOS).Results:  We observed a favorable outcome (GOS 5–4) in both groups of patients admitted with moderately good clinical conditions (H–H 1–3), with no statistically significant difference. In contrast, in the case of H–H grade at admission > 3, we observed a statistically significant poor outcome in elderly patients.Conclusions:  We consider the endovascular treatment as first choice for elderly patients presenting with a good H–H grade at admission. Quick functional recovery and reduced hospitalization time were observed. Unlike young patients, a chance of recovery in elderly patients with H–H 4–5 is more difficult to achieve. Therefore, a conservative approach should be considered. Geriatr Gerontol Int 2012; 12: 46–49.
Prepubertal vulval fibroma with a coincidental ectopic breast fibroadenoma: Report of an unusual case with literature review
Authors: Zhang Jian , Chen Yue , Wang Kana , Xi Mingrong , Yang Kaixuan , Liu Hui 
Published: July 2011

AbstractPrepubertal vulval fibroma and ectopic breast fibroadenoma of the vulva are two rare tumors, and they are very difficult to distinguish from other vulval masses, both clinically and pathologically. The complication of the two diseases is extremely rare. We report the case of an extremely large and progressively enlarging mass in the vulva of an 18‐year‐old Chinese girl. The mass was excised completely and pathologically diagnosed as a prepubertal vulval fibroma and ectopic breast fibroadenoma. The patient was followed up for 10 months and no evidence of recurrence was observed. Prepubertal vulval fibroma and vulval ectopic breast fibroadenoma should be considered in their preoperative differential diagnosis of a vulval mass, especially in prepubertal girls. Pathologically, immunohistochemical staining for vimentin and CD34 is valuable for diagnosis. Complete surgical excision is effective and long‐term follow up is necessary.
Influence of regular aerobic exercise on endothelium‐dependent vasodilation and cardiorespiratory fitness in pregnant women
Authors: Ramírez‐Vélez Robinson , Aguilar de Plata Ana Cecilia , Escudero Mildrey Mosquera , Echeverry Isabella , Ortega José Guillermo , Salazar Blanca , Rey Juan José , Hormiga Claudia , López‐Jaramillo Patricio 
Published: July 2011

AbstractAim:  To evaluate the effect of regular aerobic exercise on the endothelial function and cardiorespiratory fitness in pregnant women.Method:  This was a randomized, double‐blinded, controlled clinical trial of 64 healthy primigravid women between 16 and 20 weeks' gestation. The experimental group took part in aerobic exercise at an intensity of 50–65% of their maximum heart rate for 60 min, three times a week for 16 weeks. The control group undertook their usual physical activity. The outcomes were the endothelial function evaluated by flow‐mediated dilatation and cardiorespiratory fitness evaluated by the maximum indirect oxygen consumption (VO2max) in a 6‐min walk test.Results:  Initially, no differences were found between the groups in any of the variables. At the end of the intervention, the participants that performed exercise showed a higher cardiorespiratory fitness, measured by the walked distance in the 6‐min walk test (P = 0.014) and by the VO2max (P = 0.014). Also, the exercise group showed a lower heart rate at rest and a higher flow‐mediated dilatation than the control group (P = 0.02).Conclusions:  Regular aerobic exercise improves endothelium‐dependent vasodilation in pregnancy. This intervention may be an early and effective alternative to strengthen the prevention of disorders associated to endothelial dysfunction.
The sculpture and morphology of postcranial dermal armor plates and associated bones in gasterosteiforms and syngnathiforms inhabiting Estonian coastal waters
Authors: Lees Janek , Märss Tiiu , Wilson Mark V. H. , Saat Toomas , Špilev Heli 
Published: July 2011

AbstractLees, J., Märss, T., Wilson, M. V. H., Saat, T. and Špilev, H. 2011. The sculpture and morphology of postcranial dermal armor plates and associated bones in gasterosteiforms and syngnathiforms inhabiting Estonian coastal waters. ―Acta Zoologica (Stockholm) 93: 422–435.Five fish species inhabiting Estonian coastal waters (Gasterosteus aculeatus L., Pungitius pungitius (L.), and Spinachia spinachia (L.) of the order Gasterosteiformes and Syngnathus typhle L. and Nerophis ophidion (L.) of the order Syngnathiformes) are described on the basis of the sculpture and morphology of their postcranial dermal armor plates, as revealed and illustrated by SEM images. This study shows that the shapes of these superficial skeletal elements vary by species as well as by their position on the body, whereas the sculpture on the bones is taxon specific. The detailed features allow the identification of isolated fossil and subfossil remains and show promise for future systematics studies.
Defining predictors of response to intralesional verapamil injection therapy for Peyronie’s disease
Authors: Moskovic Daniel J. , Alex Byron , Choi Judy M. , Nelson Christian J. , Mulhall John P. 
Published: July 2011

Study Type – Therapy (case series)Level of Evidence 4What’s known on the subject? and What does the study add?Intralesional verapamil (ILV) injection therapy is useful to prevent progression of Peyronie’s Disease in some patients.These data are analyzed to identify predictors to better indentify patients likely to benefit from ILV therapy.OBJECTIVE• To assess factors that predict penile curvature responses to intralesional verapamil (ILV) injection therapy for men with Peyronie’s disease (PD).PATIENTS AND METHODS• Men with PD for <1 year were assessed at baseline and after 3 months of bi‐monthly ILV‐injection therapy. Curvature was assessed at the time of maximum penile rigidity.• Univariate relationships were tested with correlation or chi‐square analyses.• Multivariate analyses included logistic and linear regression.• We analysed curvature improvement, defined as a decrease of ≥10 ° from baseline. Additionally, the relationship between curvature outcomes and patient age and degree of baseline penile curvature were assessed.RESULTS• Data from 131 men were included and the rates of penile curvature change were:26% improved, 12% worsened, and 62% stable.• Age (r=−0.24, P < 0.01) and larger baseline penile curvature (r= 0.33, P < 0.01) were associated with improved curvature on univariate analysis.• On multivariate analysis (logistic regression), both age [odds ratio (OR) 0.93, P < 0.01, 95%CI 0.89–0.97] and larger baseline penile curvature (OR 1.07, P < 0.01, 95%CI 1.04–1.11) were associated with improvements in curvature after ILV‐injection therapy.• Improvements in curvature were associated with age (≤40 years vs >40 years; OR 0.27, P < 0.05, 95%CI 0.10–0.75) and degree of penile curvature at baseline (≤30 ° vs >30 °; OR 9.12, P < 0.01, 95%CI 1.94–42.84) when dichotomized as indicated.CONCLUSION• Younger age and larger baseline penile curvature were predictive of favourable curvature outcomes.• Analysis of dichotomized variables suggests that age and baseline curvature thresholds may be important to consider when deciding on ILV as a therapeutic strategy for PD.
A review of educational strategies to improve nurses' roles in recognizing and responding to deteriorating patients
Authors: Liaw S.Y. , Scherpbier A. , Klainin‐Yobas P. , Rethans J.‐J. 
Published: July 2011

LIAW S.Y., SCHERPBIER A., YOBAS P. & RETHANS J.‐J. (2011) A review of educational strategies to improve nurses' roles in recognizing and responding to deteriorating patients. International Nursing Review58, 296–303Background:  Physiological instability leading to clinical deterioration often precedes cardiopulmonary arrest. Nurses, who have the most frequent patient contact and responsibility for ongoing monitoring of patients, play a crucial role in recognizing and responding to clinical deterioration. The importance of education in supporting such a role has been addressed in numerous studies.Aim:  This study aimed to identify nurses' educational needs and explore educational strategies to enhance their ability in recognizing and managing wards with deteriorating patients.Methods:  A literature search from databases (2000–2010) was undertaken to include papers that identified the educational needs of ward nurses and existing educational programmes related to the care of deteriorating patients.Findings:  Twenty‐six papers were included in this review. Findings identified the educational need to empower nurses with the appropriate knowledge and skills in recognizing, reporting and responding to patient deterioration. The review of existing educational programmes and their outcomes identified valuable teaching information and strategies, and areas that could be improved in meeting nurses' educational needs.Conclusion:  The review has highlighted important aspects of patient safety in clinical deterioration that could be further addressed by educational strategies targeting the role of ward nurses. These strategies include: utilizing clinical decision‐making models to develop nurses' decision making skills; developing a standardized tool for systematic nursing assessment and management of clinical deterioration; incorporating training in clinical deterioration as a core competence of pre‐registered nursing education; providing vital signs training to nursing assistants; and conducting more rigorous studies to evaluate the effectiveness of the educational programmes.
Introducing traditional Chinese nursing: a review of concepts, theories and practices
Authors: Hao Y. , Liu H. , Yue S. , Liu X. 
Published: July 2011

HAO Y., LIU H., YUE S. & LIU X. (2011) Introducing traditional Chinese nursing: a review of concepts, theories and practices. International Nursing Review58, 319–327Aim:  This paper discussed the basic concepts, theories and practices of traditional Chinese nursing (TCN) to enrich our understanding of relevant concepts and ways to contribute to human health.Background:  Advantages of TCN include health education based on theories and techniques of traditional Chinese medicine. It focuses mainly on mobilizing humans' capacity for self‐adjustment and self‐rehabilitation to make a dynamic balance between yin and yang, qi and blood and zang and fu. It has played a significant role in the fields of primary nursing, geriatric nursing, hospice, family nursing, etc., in China.Method:  PubMed, CINAHL, Ovid Medline (English) and the Wang Fang (Chinese) databases were searched for literature on a range of keywords relating to traditional Chinese medicine and nursing. Forty references (13 English and 27 Chinese) were finally selected for review.Conclusion:  Practices of nursing care in traditional Chinese medicine are based mainly on the theories of yin–yang and the five elements. There are two prime characteristics in the theoretical system of TCN: holism and nursing determination based on syndrome differentiation. The distinctive content include prevention, daily care of patients, dietary nursing, etc. TCN, with its characteristics of little damage, little pain, ease of operation and low cost, is appropriately used in primary health care in China. By combining Western and Eastern philosophies and approaches to nursing, life phenomena can be better understood, and more ways to promote health can be exploited. Scientists are beginning to use Western research methods to establish effectiveness. Many common interventions would not, however, be considered safe in Western nursing practice without more evidence and consideration of health and safety issues.
Evaluating information literacy educators’ practices before and after the course facilitating information literacy education: from tutor to learner‐centred
Authors: Andretta Susie 
Published: July 2011

AbstractObjective:  The article gives an account of a study on the impact of facilitating information literacy education (FILE) on its participants, health librarians who have attended this course between 2007 and 2010.Methods:  The analysis presented here is based on the first stage of the research, funded by the Higher Education Academy Information and Computer Sciences and consisting of an online survey. This survey was conducted in Autumn 2010 and examined the respondents’ examples of information literacy practice before and after FILE.Results and conclusion:  Two main outcomes can be drawn from the data. First, that overall the respondents’ provision of information literacy education has shifted from a tutor‐centred approach (where the trainer decides what the learner needs) to a learner‐centred approach (where the learner decides what he/she needs). And secondly, that the impact of FILE should be seen in terms of a self‐perpetuating professional development, rather than measured in terms of specific changes that occur at set times (e.g., at the end of the course or 6 months after completion). As one FILE participant puts it: ‘When FILE ends your career as an information literacy professional starts.’
Malignancies and mortality in 200 patients with primary sclerosering cholangitis: a long‐term single‐centre study
Authors: Fevery Johan , Henckaerts Liesbet , Van Oirbeek Robin , Vermeire Séverine , Rutgeerts Paul , Nevens Frederik , Van Steenbergen Werner 
Published: July 2011

Abstract
Background: The outcome of primary sclerosing cholangitis (PSC) has improved by liver transplantation (LT), but patients often develop malignancies. We analysed morbidity and mortality patterns to define strategies to prevent complications.
Methods: Two hundred consecutive patients diagnosed before October 2005 were studied.
Results: Malignancies developed in 40 (20%) and led to death in 28 patients (45.9% of the 61 mortalities). Cholangiocarcinoma (CCa) developed in 13 patients, and was detected shortly after the diagnosis of PSC in 31%. Colorectal carcinomas were documented in 10 and dysplastic adenomas in four patients; eight had ulcerative colitis, two Crohn's colitis, one unclassified inflammatory bowel disease (IBDu), three had no IBD. Five died of colorectal cancer. Three carcinomas and two adenomas were localized in the caecum or ascending colon, but most (n=10) in the recto‐sigmoidal region. Hepatocellular carcinoma developed in three patients with advanced fibrosis/cirrhosis, and pancreatic cancer in five. LT has been carried out in 42 patients, 6.1 years (median, 0.5–25) after the diagnosis of PSC. Mortality was due to hepatic complications in 13 patients. Within 5 years of the diagnosis, deaths were because of malignancy in 12 patients and to hepatobiliary decompensation in only three, whereas 18 had been transplanted.
Conclusions: Since the use of transplantation, malignancies are the major cause of death. CCa has to be searched for in any new symptomatic patient. Colorectal malignancy occurs frequently. Colonoscopy at the diagnosis of PSC is obligatory and should be repeated at 1–2 years interval in the patients with IBD and every 5 years in those without IBD.
Endothelial dysfunction in the regulation of cirrhosis and portal hypertension
Authors: Iwakiri Yasuko 
Published: July 2011

AbstractPortal hypertension is caused by an increased intrahepatic resistance, a major consequence of cirrhosis. Endothelial dysfunction in liver sinusoidal endothelial cells (LSECs) decreases the production of vasodilators, such as nitric oxide, and favours vasoconstriction. This contributes to an increased vascular resistance in the intrahepatic/sinusoidal microcirculation and develops portal hypertension. Portal hypertension, in turn, causes endothelial dysfunction in the extrahepatic, i.e. splanchnic and systemic, circulation. Unlike dysfunction in LSECs, endothelial dysfunction in the splanchnic and systemic circulation causes overproduction of vasodilator molecules, leading to arterial vasodilation. In addition, portal hypertension leads to the formation of portosystemic collateral vessels. Both arterial vasodilation and portosystemic collateral vessel formation exacerbate portal hypertension by increasing the blood flow through the portal vein. Pathological consequences, such as oesophageal varices and ascites, result. While the sequence of pathological vascular events in cirrhosis and portal hypertension has been elucidated, the underlying cellular and molecular mechanisms causing endothelial dysfunctions are not yet fully understood. This review article summarizes the current cellular and molecular studies on endothelial dysfunctions found during the development of cirrhosis and portal hypertension with a focus on the intra‐ and extrahepatic circulations. The article ends by discussing the future directions of the study for endothelial dysfunction.
MRI‐negative epilepsy: Protocols to optimize lesion detection
Authors: Vézina Louis‐Gilbert 
Published: July 2011

SummaryIdentification of the structural lesions that underlie pediatric epilepsy can be challenging. Careful evaluation of the gray–white matter interface is crucial, and necessitates multiplanar thin images of high resolution that can differentiate focal lesions from partial volume averaging artifacts created by the innate gyral configuration. Careful evaluation of the hippocampus and of the myelination patterns can further increase the diagnostic yield of the study. Magnetization transfer imaging can call attention to a lesion that is either very subtle or not evident on conventional sequences. Detection of cortical anomalies is best performed early in infancy, preferably before 6 months of age. If the initial magnetic resonance imaging (MRI) scan is performed between 9 and 18 months of age and is negative, a repeat scan after 2 years of age may be necessary.
Diffusion tensor imaging in temporal lobe epilepsy
Authors: Gross Donald W. 
Published: July 2011

SummaryAlthough mesial temporal sclerosis (MTS) has long been recognized in association with temporal lobe epilepsy (TLE), there is a growing body of literature suggesting structural abnormalities extending beyond the temporal lobe in patients with TLE. Diffusion tensor imaging (DTI) is a novel imaging technique that provides insight into the structural integrity of cerebral white matter. DTI studies have demonstrated extensive bilateral white matter abnormalities in TLE that extend far beyond the temporal lobe, even in patients with unilateral MTS. The relationship between white matter abnormalities, seizures, and comorbidity in TLE remains unclear.
Gender and drug effects on neuroimaging in epilepsy
Authors: Koepp Matthias J. 
Published: July 2011

SummaryMen are different from women, and patients with epilepsy are different in many aspects from healthy control subjects. Quantitative or semiquantitative analysis of neuroimaging data depends on the comparison between either a single patient against a group of healthy or unaffected controls, or comparisons between groups of patients and controls. Matching for gender is desired, but is sometimes not possible, for example, in the case of nuclear medicine with women in childbearing age usually not being recruited as healthy controls. Antiepileptic drug treatment is the other major confounder for comparisons of cognitive functioning between patients and healthy control subjects. Whether these two covariates, gender and drug effects, are of interest or nuisance variables depends on the question and design of the neuroimaging study.