bluuebunny/crossref_metadata_2025_split huggingface dataset:
Successful percutaneous closure of a coronary artery fistula with a detachable balloon
Authors: OZASA HIROSHI , KAMIYA ICHIRO , HANEDA NORIYUKI 
Published: January 2011

AbstractPrecutaneous transcatheter closure technique of a coronary artery fistula with a detachable balloon was performed for a 14 year old male student. Complete closure of the fistula without any complications was confirmed by angiography after the procedure. When the patient underwent a second angiography 6 months after the closure, it was confirmed that the position of the balloon had not changed, that the interruption of the flow of the fistula had been maintained and that the diameter of the left coronary artery and the fistula were reduced. Percutaneous closure technique using a detachable balloon may become the primary treatment for a coronary artery fistula in place of surgical ligation.
Serum and cerebrospinal fluid zinc levels in children with febrile convulsions
Authors: GÜNDÜZ ZÜBEYDE , YAVUZ İSMET , KOPARAL MEHMET , KUMANDAŞ SEFER , SARAYMEN RECEP 
Published: January 2011

AbstractThe mechanisms underlying febrile convulsions (FC), which have multiple etiological factors, are not yet clear. The aim of the present study was to determine whether there were any changes in serum and cerebrospinal fluid (CSF) zinc (Zn) levels in children with febrile convulsion during seizures. A total of 102 children were included in the study, with four groups formed as follows: group A, 40 children with FC (aged 9 months to 5 years); group B, 20 children having fever without convulsion (aged 6 months to 5 years); group C, 20 children with afebrile convulsion (aged 6 months to 6 years) and group D, 22 healthy children (aged 5 months to 6 years). Serum and CSF zinc levels for groups A, B and C and serum Zn levels only for group D were measured. The serum Zn levels of 17 children in group A were again measured during healthy periods. Serum Zn levels of groups A, B, C and D had a mean of 0.70 ± 0.10 mg/dL, 1.07 ± 0.08 mg/dL, 1.26 ± 0.32 mg/dL and 1.17 ± 0.21 mg/dL, respectively, and the values of group A were lower than those of the other three groups (P < 0.001). In group B, serum Zn levels were also lower than those of groups C and D (P < 0.05). The CSF Zn levels of groups A, B and C were found to have a mean of 0.07 ± 0.02 mg/L, 0.12 ± 0.02 mg/L and 0.14 ± 0.04 mg/L, respectively. In group A, the CSF Zn levels were lower than those of groups B and C (P < 0.001), and in group B they were lower than those of group C (P < 0.05). For the 17 patients in group A, serum Zn levels during healthy periods (0.87 ±0.10 mg/dL) were found to be higher than the values shortly after seizures, but lower than those of groups B, C and D (P < 0.001). We could not observe any relationship between zinc levels of the serum and CSF and the degree and duration of the fever. These findings suggest that serum and CSF Zn levels decreased during infectious diseases, and that this decrease was more significant in patients with FC.
Long‐term follow up of abdominal aortic aneurysm complicating Kawasaki disease: Comparison of the effectiveness of different imaging methods
Authors: FUYAMA YUUICHI , HAMADA ROUSEI , UEHARA RITEI , YANO ICHIRO , FUJIWARA MASAKO , MATOBA MASAKO , KAWAMURA KENICHI , NONAKA ZENJI , MAEKAWA KIHEI 
Published: January 2011

AbstractA 2 month old boy with Kawasaki disease developed the rare complication of abdominal aortic aneurysm (AAA). He was followed up over 7 years by ultrasonography (2D‐ECHO) with and without Doppler flow evaluation, angiography and computed tomography. Calcification was noted 33 months after the onset of the disease but the aneurysm did not decrease in size.2D‐ECHO was adequate for evaluating the size of an aneurysm, but did not show thrombus formation or calcification. Doppler flow studies did not show abnormally high blood flow velocities either at the inflow or outlet of aneurysms, which are indicative of stenosis. On the other hand an abdominal aortogram provided information regarding the luminal shape and abnormalities in flow pattern suggestive of thrombus formation. Fluoroscopy cannot demonstrate calcification in the early stages. Computed tomography (CT) was the imaging method of choice for the evaluation of obstructive or calcific changes; an organizing thrombus was clearly demonstrated and early detection of calcification was possible.
Dyskeratosis congenita: Unusual onset with isolated neutropenia at an early age
Authors: YEL LEMAN , TEZCAN ILHAN , SANAL ÖZDEN , ERSOY FÜGEN , BERKEL A IZZET 
Published: January 2011

AbstractA 3.5 year old male patient with dyskeratosis congenita (DC) presented at the age of 13 months with isolated neutropenia preceding characteristic skin findings. The average absolute neutrophil count of 500/mm3 persisted without the presence of anemia or thrombocytopenia during the follow up. Neutropenia responded to granulocyte‐colony stimulating factor (G‐CSF) at a dose of 10 μg/kg per day. Immunologic findings were normal as was the chromosomal stability and sister chromatid exchange.
Granulocyte transfusion: Stimulation of low dose granulocyte colony‐stimulating factor in donors for leukapheresis
Authors: NOMURA AKIHIKO , OHGA SHOUICHI , MATSUZAKI AKINOBU , KAI TAKESHI , INABA SHOICHI , SUDA MASAHIRO , UEDA KOHJI 
Published: January 2011

AbstractIn order to assess the clinical utility of granulocyte transfusions (GT), the stimulating effects of donor granulopoiesis for GT therapy were examined using either low dose recombinant human granulocyte colony‐stimulating factor (rhG‐CSF) or dexamethasone (DEX). The increment of leukocytes, polymorphonuclear cells (PMN) and monocytes in the subjects stimulated with rhG‐CSF (0.7 μg/kg SC) surpassed each increment in those with DEX alone (1 mg PO). The lymphocyte counts after DEX stimulation decreased in contrast to those after G‐CSF stimulation. This dose of G‐CSF did not enhance the priming effects on the superoxide release from PMN. The serum levels of lysozyme, but not of lactate dehydrogenase, in G‐CSF stimulated donors were higher than those in DEX‐treated donors. The serum macrophage/monocyte‐colony stimulating factor (M‐CSF) levels in DEX stimulation were lower than in either G‐CSF stimulation or no stimulation. The net yield of the PMN in GT on G‐CSF stimulation was practically larger than that on DEX stimulation. One of the two patients who received GT collected by DEX stimulation died of aspergillosis. Two of the five patients who received PMN mobilized by G‐CSF died of fungal infections or necrotizing fasciitis, although two of the remaining patients overcame severe bacterial infections. These results suggest that low dose G‐CSF effectively and safely mobilizes a sufficient quantity of PMN from GT‐donors without excessive superoxide generation from the transfused cells. This low dose G‐CSF stimulation may be substituted for conventional DEX stimulation for GT.
Flow cytometric evaluation of the DNA profile and cell cycle of zinc supplemented human Chang liver cells
Authors: PARAMANANTHAM RAMANUJAM , BAY BOON‐HUAT , SIT KWOK‐HUNG 
Published: January 2011

AbstractZinc, an essential trace element, is important for normal cell growth. Growing children, especially at puberty, require increased zinc (2.8 mg/day for males and 2.65 mg/day for females). The DNA profile and cell cycle of human Chang liver cells grown in 0–900 μmol/L zinc chloride supplemented serum‐free media for 24 h were analyzed using a Coulter flow cytometer. There was no significant difference in the G1, S and G2/M phases between zinc treated cells and control cultures except at 90 and 900 μmol/L zinc chloride. At these two higher dosages, fragmentation of genomic DNA into sub‐2N DNA (sub‐G1 DNA), generally considered a hallmark of programmed cell death (PCD), was noted. Results of the present study seem to suggest that growth regulation by zinc during growth spurts such as at puberty, could also be influenced by other factors besides its direct effect on DNA synthesis. In addition, high dosages of zinc could be cytotoxic.
Cerebral energy metabolism in insulin induced hypoglycemia in newborn piglets: in vivo31P‐nuclear magnetic resonance spectroscopy
Authors: IMAI TADASHI , KONDO MASATOSHI , ISOBE KENICHI , ITOH SUSUMU , ONISHI SHOJU 
Published: January 2011

AbstractThe effect of insulin induced hypoglycemia on cerebral energy metabolism was examined in four newborn piglets. Cerebral energy metabolism was assessed using in vivo 31P‐nuclear magnetic resonance spectroscopy. It was demonstrated that the normal level of phosphocreatine/inorganic phosphate (PCr/Pi), an indicator of phosphorylation potential, was maintained at a blood glucose level of 40 mg/dL or above, whereas when blood glucose was reduced to less than 40 mg/dL, PCr/Pi rapidly decreased in parallel with this. Below the critical blood glucose level of 40 mg/dL, a positive correlation (y = 0.02x + 0.632; r = 0.668; P < 0.001) existed between blood glucose and PCr/Pi. In the present investigation, a reduction of blood glucose level to 20 mg/dL or lower resulted in a PCr/Pi of less than 1, indicating a state of cerebral energy failure. The intracellular pH (pHi) was 7.08 ± 0.05 at the onset and 7.15 ± 0.07 in the hypoglycemic state, indicating no significant difference between the two groups. The present study has clarified that cerebral energy failure occurs when the blood glucose level is about 20 mg/dL or lower. The critical point of blood glucose exists to maintain brain energy metabolism.
A case of prolonged human parvovirus B19 DNA‐emia associated with polyclonal B cell activation
Authors: NOBUTOKI TATSUROU , HORI HIROKI , HIGASHIGAWA MASAMUNE , AZUMA EICHI , SAKURAI MINORU , YOSHIZUMI TAMOTSU , NUNOUE TADASU 
Published: January 2011

AbstractThe current paper reports an 8 year old girl with arthralgia and polyclonal B cell activation induced by human parvovirus B19 infection (HPV B19). The infection was diagnosed by the presence of the virus genome in sera. The patient presented with transient arthritis in the wrist, ankle joint and neck and elevation of immunoglobulin IgM antibodies to HPV B19 and rubella, antibodies to Mycoplasma and antistreptolysin O but without the typical clinical features of erythema infectiosum. The polyclonal B cell activation was paralleled by the presence of the virus genome of HPV B19 in sera. In some children with arthralgia, it is important to examine the genomes of viruses that may cause arthritis as well as the antibody titers to the viruses.
Intractable wheezing in infants with nasopharyngeal reflux
Authors: KUROKI HARUO , ISHIKAWA NOBUYASU , KUROSAKI TOMOMICHI , NIIMI HIROO 
Published: January 2011

AbstractTwo infants with intractable wheezing and moist cough were referred to Chiba Municipal Kaihin Hospital. Their symptoms were persistent even after the usual treatment for respiratory disease. No definite etiological agents were detected. They usually gagged while feeding and barium swallow tests revealed nasopharyngeal reflux and cricopharyngeal incoordination. One of the patients had remarkably high titers of IgE and IgE RAST of cow's milk before she received treatment with thickened formula. She also had peripheral eosinophilia and nasal eosinophilia. These findings were thought to be caused by nasopharyngeal reflux. Four months after therapy commenced, those titers and symptoms were greatly reduced. The clinical and roentgenographic findings in these infants, and their response to therapy, strongly support a causal relationship between nasopharyngeal reflux and wheezing. Therefore, nasopharyngeal reflux should be considered when a baby has intractable wheezing, even when there is no developmental problem.
Efficacy of salmeterol in the treatment of childhood asthma
Authors: TOMAÇ NAZAN , TUNCER AYFER , SARAÇLAR YILDIZ , ADALIOǦLU GÖNÜL 
Published: January 2011

AbstractThe aim of the clinical study reported here was to investigate the efficacy of salmeterol, a new long‐acting selective β2‐agonist, in patients with bronchial asthma. Twenty‐four children with moderate asthma were enrolled in the longitudinal study, consisting of a run‐in period of 2 weeks followed by a treatment period of 4 weeks. Maintenance treatment consisted of inhaled corticosteroid and disodium cromoglycate, or both, at the same daily dose throughout the study. During the run‐in period, the patients continued to inhale salbutamol when needed and some of them (37%) also received theophylline. They were subsequently treated with salmeterol 50 μg twice daily and prn salbutamol for 4 weeks. Efficacy was evaluated using symptom scores and pulmonary function tests including forced vital capacity parameters, pulmonary volumes, airway resistance and specific airway conductance that were measured sensitively by a whole body plethysmograph. As a result, salmeterol produced significant improvement in morning and evening peak expiratory flow rates, vital capacity, airway resistance, conductance and asthma symptoms versus salbutamol and theophylline. Adverse reactions were judged to be mild and few.
Exercise‐induced ventricular tachycardia without demonstrable heart disease in childhood
Authors: NAGASHIMA MASAMI , BABA REIZO , GOTO MASAHIKO , NISHABATA KENJI , NAGANO YOSHIKO 
Published: January 2011

AbstractExercise‐induced ventricular tachycardia (VT) without demonstrable heart disease was studied in pediatric patients. The study population consisted of 17 patients aged 5–14 years (average 9.1 years), who demonstrated reproducible VT during or immediately after exercise testing using a treadmill. The main reasons for the exercise testing were episodes of exercise‐related syncope in two patients, exercise‐related palpitation in seven and evaluation of sporadic ventricular premature contraction (VPC) in eight. Of the eight patients in the asymptomatic group, two developed sustained VT and the other six had non‐sustained VT. Of the nine patients in the symptomatic group, six developed sustained VT. Verapamil produced a good response in seven of 14 patients, and propranolol in six. None of the patients died during the follow‐up period, an average of 59.6 months. In four patients, both VT and VPC disappeared, not only on exercise testing, but also on Holter electro‐cardiograms, so the anti‐arrhythmic agents were discontinued. One patient had syncope and convulsion caused by rapid bidirectional VT in the follow‐up period. It was concluded that the prognosis of exercise‐induced VT without demonstrable heart disease in children is relatively benign, but careful follow‐up is required.
Transcatheter closure of patent ductus arteriosus using controlled‐release coils
Authors: ÇELIKER ALPAY , BİLGİÇ ARMAN , ALEHAN DURSUN , CEVİZ NACİ , LENK MUSTAFA 
Published: January 2011

AbstractControlled‐release coils have become available recently for the closure of patent ductus arteriosus (PDA). Transcatheter closure of patent arterial ducts was attempted in 13 patients, ranging in age from 5 months to 15 years, mean 4.1 years. Implantation of controlled‐release PDA coils was attempted via the femoral artery through 5 Fr catheters in all cases except one, in whom both the femoral arterial and venous routes were used. The procedure was successful in 10 of the 13 patients. In these, the pulmonary artery systolic pressure ranged between 25 and 42 mmHg and the duct diameter varied from 1.5 to 6 mm at its narrowest point. Six of the patients received a single coil. Two coils were inserted in three patients and three coils in one patient. In three patients the ducts were too large for safe release of the coils, despite attempted implantation of up to three coils simultaneously. These coils were easily withdrawn into the catheter Immediately at the end of the procedure, the duct was completely occluded in nine of the 10 patients, and in one patient there was a small residual flow. The procedure time varied between 35 min and 2.5 h, mean 81 min and the fluoroscopy time varied from 5 to 78 min, mean 25 min. None of the patients experienced hemorrhage, diminished lower extremity pulse, hemolysis or infection. In one patient, a 5 mm coil embolized into the right pulmonary artery soon after release. It was retrieved with a snare, then 8 mm and a 5 mm coil were implanted satisfactorily in the arterial duct. At follow‐up by color Doppler echocardiography, the duct was completely occluded in all patients.Transcatheter closure of patent arterial ducts by controlled‐release PDA coils is effective and safe. Even when more than one coil is inserted, it is still cheaper than transcatheter umbrella closure. This method is therefore of great value, particularly in less affluent countries.
Reversal of fluorosis in children
Authors: GUPTA SUNIL K , GUPTA RAMESH C , SETH ASHOKA K , GUPTA ALKA 
Published: January 2011

AbstractLarge populations consume fluoride‐contaminated water, especially in developing countries. The toxic effects of fluorosis take three forms: clinical, skeletal and dental. Research thus far indicates that the manifestations of fluorosis are irreversible. However, it has been observed that the ingestion of calcium, vitamin C or vitamin D, individually, is effective in protection from fluoride toxicity to a certain extent. Therefore, a double blind control trial was conducted to examine the effect of a combination of calcium, vitamin D3 and ascorbic acid supplementation in fluorosis‐affected children. In the present study, 25 children were selected from an area consuming water containing 4.5 p.p.m. of fluoride, All the children were in the age group 6–12 years and weighed 18–30 kg. They were graded for clinical, radiological and dental fluorosis and relevant biochemical parameters. Grade I skeletal fluorosis and all grades of the manifestation of dental and clinical fluorosis were observed. The children were given ascorbic acid, calcium and vitamin D3 well below the toxic dosages in a double blind manner using lactose as a placebo. Follow up revealed a significant improvement in dental, clinical and skeletal fluorosis and relevant biochemical parameters in these children. Thus, the study indicated that fluorosis can be reversed, at least in children, by a therapeutic regimen that is fairly cheap, simple and easily available and without any side effects.
Effect of clonidine on the height of a child with glycogen storage disease type VI: A 13 year follow‐up study
Authors: ASAMI TADASHI , KIKUCHI TOURU , ASAMI KEIKO , UCHIYAMA MAKOTO 
Published: January 2011

AbstractA 9‐month‐old male was found to have hepatomegaly when he was treated by his doctor for bronchitis. At the age of 2 years and 3 months, glycogen storage disease (GSD) of type VI (GSD VI) was diagnosed in this patient. Despite the recommended diet therapy, his growth was not good, changing under or along the line of −2.0 SD. At the age of 6 years, oral clonidine therapy (0.15 mg/day, 0.2 mg/m2 body surface per day) was started. Six to 10 months after the initiation of clonidine therapy, his height began to increase more than the values for −2.0 SD and once reached the value for −1.0 SD at the age of 10 years. His growth rate and bone age increased. Clonidine therapy was continued regularly for 7 years until the age of 13 years, 11 months. At that time his development was normal and his height reached 150.8 cm (–1.34 SD). However, cessation of the treatment at the patient's free will resulted in a reduction of the growth rate at age 15 years 6 months. These observations suggest the effect of clonidine therapy on height. Side effects were not noted during the clonidine therapy. Other clinical and laboratory findings of GSD VI also completely improved during treatment. In conclusion, administration of clonidine could be another treatment modality in children with GSD, not only of type VI but also I and III.
Motor nerve conduction studies on children with spinal muscular atrophy
Authors: MIYANOMAE YURI , TAKEUCHI YOSHIHIRO , NISHIMURA AKIRA , KAWASE SYOUJI , HIRAI KIYOSHI , OCHI MASAHARU , SAWADA TADASHI 
Published: January 2011

AbstractMedian and posterior tibial motor nerve conduction studies were performed on 10 children with spinal muscular atrophy (SMA). Three patients with SMA type I, in whom rapid deterioration occurred, showed reduced motor nerve conduction velocity and a remarkably low M‐wave amplitude in both nerves. In type II and III patients, the motor nerve conduction velocity was normal in the median nerve, although the M‐wave amplitude was small in the tibial nerve. In four patients, a reduction of the M‐wave amplitude was observed as clinical symptoms advanced. These findings may suggest that motor conduction studies in spinal muscular atrophy provide complementary information for understanding the pathogenesis and are also useful to clarify the heterogeneity of this disease.
Change of renal function during vancomycin therapy in extremely low birthweight infants
Authors: SAKATA HIROSHI , MARUYAMA SHIZUO , ISHIOKA TORU , SHIRAI MASARU , TAKETAZU MIO , TAKETAZU GENYA 
Published: January 2011

AbstractTwenty extremely low birthweight infants were treated with vancomycin (VCM). Their gestational age was 26.3 ± 1.4 weeks (range 24.0–28.7 weeks) and their birthweight was 829 ± 133 g (range 562–990 g). At the time of initial administration of VCM, postnatal age was 29.5 ± 15.8 days (range 5–54 days). Vancomycin was administered in a dose between 9.3 and 11.0 mg/kg every 12 h for a period of 6.3 ± 2.4 days (range 4–13 days). Serum and urinary specimens were obtained before and after (within 24 h following the last dose) VCM therapy. Serum creatinine and sodium, and urinary N‐acetyl‐β‐D‐glucosaminidase (NAG) activity, creatinine, sodium, and β‐2‐microglobulin (BMG) concentrations were measured. Fractional excretion of sodium (FENa) and NAG index (NAG: creatinine ratio) were calculated. There were no significant differences between the before and after VCM treatment in serum creatinine, urinary BMG concentration, FENa and NAG index. No infant showed any symptoms of renal insufficiency. However, the NAG index and FENa increased after treatment in 1 of 20 infants. Vancomycin is effective and safe in the treatment of serious infections in extremely low birthweight infants.
Left and right ventricular volume characteristics in tetralogy of Fallot and their relationship to arterial oxygen saturation and age
Authors: AKIBA TOMOHARU , NAKASATO MITSURU , SATO SATOSHI , ISHIKAWA ATSUKO , SATO TETSUO 
Published: January 2011

AbstractLeft (LV) and right ventricular (RV) volume characteristics in 43 patients with tetralogy of Fallot (TOF) undergoing no prior surgical intervention, aged 3–50 months, were evaluated. The control group consisted of 45 patients with Kawasaki disease without cardiac lesions, aged 12–82 months. The TOF patients were divided into four groups: those having arterial oxygen saturation < 80% with an age at the time of study < 18 months (group 1a) or with that ≧ 18 months (group 1b), and those with arterial oxygen saturation ≧ 80% with an age < 18 months (group 2a) or with that ≧ 18 months (group 2b). The results were compared with those in control subjects. In group 1a, each of LV end‐diastolic volume (EDV), LV ejection fraction (EF), RVEDV and RVEF was reduced. In group 1b, LVEDV, LVEF and RVEF were decreased. In groups 2a and 2b, RVEF alone was depressed. From these results, the severity of hypoxemia was an important risk factor for ventricular dysfunctions. No influence of age on the volume characteristics was found. The investigations suggested that patients with TOF having an arterial oxygen saturation < 80% are probably candidates for early surgical intervention.