bluuebunny/crossref_metadata_2025_split huggingface dataset:
Patient-reported burden in adults with atopic dermatitis: an international qualitative study
Authors: Wollenberg Andreas , Gooderham Melinda , Katoh Norito , Aoki Valeria , Pink Andrew E. , Binamer Yousef , Silverberg Jonathan I. 
Published: June 2024

AbstractThe objective was to study a large, international, ethnically diverse population of patients with atopic dermatitis (AD) to support the creation of patient-centric recommendations for AD management. Qualitative data were generated from 45-min, 1:1 telephone interviews conducted across 15 countries in each patient’s native language. Interviews explored the impact of AD on patients’ lives, patients’ most important symptoms, treatment expectations, and treatment decision-making. Participants were also questioned on their current knowledge of AD scoring systems and what was most important to include in these tools. In total, 88 adult patients (≥ 18 years old) receiving treatment for AD were recruited through a market research database, clinician referrals, and local advertising. All patients were screened to ensure a balanced and diverse sample in terms of age, gender, educational level, employment status, geographic location, and AD severity. Patients involved in market research or activities supporting advocacy groups within the previous 6 months or affiliated with or employed by pharmaceutical companies were excluded. AD had a substantial impact on patients’ lives. Itch, skin redness, and dry/flaky skin were the most frequently reported symptoms, with > 75% of patients experiencing these symptoms every 1–3 days. Mental health issues were common and resulted in the greatest negative impact on patients’ daily lives. Patients perceived clinicians to underestimate the burden of their AD. Patients had little awareness of AD scoring systems and indicated a preference for these to be more clearly incorporated in clinical practice. For an ideal scoring system, patients favored using a combination of patient-reported and clinician-reported outcomes to reflect disease burden and ensure consistency across all settings. This global study generated diverse patient perspectives on the disease burden of AD, their expectations of treatment, and their views on AD scoring methods. These data provide evidence to support the development of patient-centric recommendations for AD management.
Antibiotic treatment after appendectomy for acute complicated appendicitis to prevent intrabdominal abscess and wound infections
Authors: Laverde Bruno Leonardo Bancke , Maak Matthias , Langheinrich Melanie , Kersting Stephan , Denz Axel , Krautz Christian , Weber Georg F. , Grützmann Robert , Brunner Maximilian 
Published: June 2024

Abstract
Introduction
The purpose of this analysis was to investigate the most appropriate duration of postoperative antibiotic treatment to minimize the incidence of intraabdominal abscesses and wound infections in patients with complicated appendicitis.

Materials and methods
In this retrospective study, which included 396 adult patients who underwent appendectomy for complicated appendicitis between January 2010 and December 2020 at the University Hospital Erlangen, patients were classified into two groups based on the duration of their postoperative antibiotic intake: ≤ 3 postoperative days (group 1) vs. ≥ 4 postoperative days (group 2). The incidence of postoperative intraabdominal abscesses and wound infections were compared between the groups. Additionally, multivariate risk factor analysis for the occurrence of intraabdominal abscesses and wound infections was performed.

Results
The two groups contained 226 and 170 patients, respectively. The incidence of postoperative intraabdominal abscesses (2% vs. 3%, p = 0.507) and wound infections (3% vs. 6%, p = 0.080) did not differ significantly between the groups. Multivariate analysis revealed that an additional cecum resection (OR 5.5 (95% CI 1.4–21.5), p = 0.014) was an independent risk factor for intraabdominal abscesses. A higher BMI (OR 5.9 (95% CI 1.2–29.2), p = 0.030) and conversion to an open procedure (OR 5.2 (95% CI 1.4–20.0), p = 0.016) were identified as independent risk factors for wound infections.

Conclusion
The duration of postoperative antibiotic therapy does not appear to influence the incidence of postoperative intraabdominal abscesses and wound infections. Therefore, short-term postoperative antibiotic treatment should be preferred.
Development of the neonatal pain response variable set: a mixed methods consensus process
Authors: Zhu Nanxi , Long Bingjie , Zhan Xinling , Zhang Lanxin , Wang Zechuan , Wang Lianhong , Huang Yi , Chen Juan , Huang Chi , Xiong Lu , Fu Zhenyan , Deng Renli 
Published: June 2024

AbstractWhile over 40 neonatal pain assessment scales have been published, owing to a lack of consensus and standardized metrics, there are more than 100 assessment indicators with varying descriptors and quality differences. This study aims to reach a consensus on optimal and comprehensive variables for neonatal pain assessment, leading to the development of a multidimensional neonatal pain response variable set. This study consisted of three phases: (1) A literature review was conducted to identify influencing factors and assessment indicators of neonatal pain response. (2) Panel meetings involving neonatal healthcare professionals evaluated and screened factors and indicators to develop an initial draft of the variable set. (3) Through two rounds of Delphi study achieved consensus, and determined the neonatal pain response variable set. Through a literature review and a panel meeting, the identified factors and indicators were categorized into contextual, physiological, and behavioral variables, forming an initial draft of the variable set. Sixteen professionals participated in two rounds of the Delphi study, with response rates exceeding 70%, and authority coefficients surpassing 0.7 in both rounds. The final iteration of the variable set includes 9 contextual variables, 2 physiological variables, and 5 behavioral variables. Conclusion: Neonatal pain response variable set developed in this study is scientific, comprehensive, and multidimensional, aligning with the characteristics of neonatal pain response and clinically applicable. The inclusion of contextual variables enhances the ability to confront the complexity of clinical environments and individual differences. It can provide a practical and theoretical basis for clinical research on neonatal pain assessment.

What is Known:• Neonatal pain assessment relies on scales used by healthcare professionals currently. But there is no “gold standard” for neonatal pain assessment.• While over 40 neonatal pain assessment scales have been published, owing to a lack of consensus and standardized metrics, there are more than 100 assessment indicators with varying descriptors and quality differences. Most of scales overlook the clinical environment complexity individual differences in pain responses, diminishing the accuracy and applicability.

What is New:• In addition to the commonly used physiological and behavioral variables in the scales, we have incorporated contextual variables to better address the complexity of clinical environments and individual differences in pain responses.• Through an evidence-based approach, developed a neonatal pain response variable set comprising 9 contextual variables, 2 physiological variables, and 5 behavioral variables.
New T staging recommendations for recurrent nasopharyngeal carcinoma
Authors: Zhu Mingjing , Li Pian , Zhang Huisi , Wu Lanhua , Min Kang 
Published: June 2024

Abstract
Objective
The International Union for Cancer Control/American Joint Committee on Cancer (UICC/AJCC) rT staging is not clinically practical for recurrent nasopharyngeal carcinoma (rNPC). The aim of this study was to establish a new rT staging to guide the treatment of rNPC.

Methods
We conducted a retrospective analysis of 175 patients diagnosed with rNPC between January 2012 and December 2020, using ROC curve analysis to evaluate its effectiveness.

Results
We analyzed the overall survival (OS) and progression-free survival(PFS) of patients diagnosed with rNPC according to the 8th (UICC/AJCC) rT staging, and found that the overall survival of rT1 and rT2 patients (OS; 29.98% vs. 27.09%, p = 0.8059) and progression-free survival (PFS; 28.48% vs. 26.12%, p = 0.4045) had no significant difference. In rT1 and rT2 patients of this study, overall survival(OS; 30.44% vs. 24.91%, p = 0.0229) and progression-free survival(PFS 29.12% vs. 24.03%, p = 0.0459) had a significant difference. Smoking, family history, and time interval of initial recurrence were independent prognostic factors for OS and PFS.

Conclusion
The new rT staging of this study has a better predictive value for survival of rNPC patients than the 8th (UICC/AJCC) rT staging.
COVID-19 pandemic and the consumption of self-care products for pediculosis capitis in Portugal: an interrupted time-series analysis
Authors: Almeida Diogo , Rodrigues Antonio Teixeira , Guerreiro Jose Pedro , Bałkowiec-Iskra Ewa , Vander Stichele Robert , Sepodes Bruno , Torre Carla 
Published: June 2024

AbstractThis study aims to assess the effect of the COVID-19 pandemic on the consumption of self-care products for pediculosis capitis management, in Portugal. A segmented regression analysis of interrupted time series (March 2020) was performed from January 2017 to August 2023 to analyze the short- and long-term impact of the COVID-19 pandemic on the consumption of pediculicides and related products. Monthly rates of absolute consumption were estimated by community pharmacies’ dispensing records. Portuguese municipalities were organized into quintiles according to their purchasing power index and percentage of youth, to study the association of these social and demographic variables on the sale of these products. COVID-19 pandemic significantly reduced the sales of products indicated for pediculosis. Since the start of the pandemic, an absolute decrease of 21.0 thousand packages was observed in the monthly average consumption (p < 0.0001) compared to the pre-pandemic period. After this reduction, the average monthly trend increased in the pandemic period in comparison with the previous period, although not significant (267.0 packages per month, p = 0.1102). Regions with higher disposable income and more young people were associated with higher sales of these products. The outbreak of the COVID-19 pandemic has had a notable impact on the sales of self-care products for pediculosis capitis in Portugal, in the short term. The lockdowns and other isolation measures implemented to control the spread of the virus may have led to a decrease in the number of head lice cases, consequently resulting in a reduction in sales of products.
Reconstructing the Belbaşhanı Pumice Plinian eruption, Hasandağ Volcano, Turkey
Authors: Özsoy Rengin , Sunyé-Puchol Ivan , Pedrazzi Dario , Akkaş Efe , Costa Antonio , Massaro Silvia , Tavazzani Lorenzo , Nazzari Manuela , Bachmann Olivier , Scarlato Piergiorgio , Miggins Daniel P. , Kaya Simge , Mollo Silvio 
Published: June 2024

AbstractHasandağ volcano (Central Anatolia, Turkey) has recently underwent an increase in local seismicity and fumarolic activity since 2013. In the past, this volcano has produced multiple large explosive eruptions during the last million years. The Belbaşhanı Pumice is the product of a sub-Plinian to Plinian eruption dated at ~ 417 ± 20.5 ka (40Ar/39Ar). Here, we present a complete volcanological study including stratigraphy, glass chemistry, pumice morphology, geochronology, and eruption source parameters with the associated uncertainties, to characterize the Belbaşhanı Pumice eruption. The eruption involved a column of 18–29 km in height, with the main dispersal axis towards the northeast. A pumice layer up to ~ 17-m-thick accumulated in proximal deposits along the Belbaşhanı path, and up to 2-m-thick in medial-distal areas (~ 18 km northeast from the vent). The high and tubular vesicularity of the pumice clasts indicates that the Belbaşhanı eruption was predominantly magmatic. The bulk volume of the Belbaşhanı Pumice fallout deposit has been estimated as 0.5 and 8 km3(with ~ 2 km3being the mean value), which corresponds to Volcanic Explosivity Index (VEI) of at least 4 and up to 6. Both isopach and isopleth maps indicate that the volcanic vent may have been located at the intersection of the Tuz Gölü fault and Ulukışla caldera, within the Hasandağ volcanic complex. The glass composition of Belbaşhanı Pumice confirms that the eruption belongs to the Hasandağ magmatic system. The reconstruction of the Belbaşhanı Pumice eruption represents an essential baseline in providing volcanological constraints for further investigations of tephra fallout hazard assessment in Central Anatolia, especially considering that a new Plinian eruption cannot be ruled out at Hasandağ volcano in the future. The chemical and geochronological datasets presented here could aid in refining tephrochronological correlations, with the goal of synchronizing paleoenvironmental and paleoclimatic records alongside archaeological sites.
Morphological changes and their associations with clinical parameters in children with nephropathic cystinosis and chronic kidney disease prior to kidney replacement therapy over 25 years
Authors: Brügelmann Malina , Müller Sophia , Bohlen Alina V. , Hohenfellner Katharina , Büscher Anja , Kemper Markus J. , Fröde Kerstin , Kanzelmeyer Nele , Oh Jun , Billing Heiko , Gellermann Jutta , Müller Dominik , Weber Lutz T. , Acham-Roschitz Birgit , Arbeiter Klaus , Tönshoff Burkhard , Hagenberg Martina , Žebec Mislav S. , Haffner Dieter , Zivicnjak Miroslav 
Published: June 2024

Abstract
Background
Infantile nephropathic cystinosis (INC) is a rare lysosomal storage disorder, mostly and often firstly affecting the kidneys, together with impaired disharmonious growth and rickets, eventually resulting in progressive chronic kidney disease (CKD). With the introduction of cysteamine therapy, most pediatric patients reach adulthood with no need for kidney replacement therapy. Still, detailed changes in INC patients’ clinical and morphological presentation over the past decades have not yet been thoroughly investigated.

Methods
Two groups with a respective total of 64 children with INC and 302 children with CKD, both treated conservatively and aged 2 to 18 years, were prospectively observed in the time span from 1998 to 2022 with 1186 combined annual clinical and morphological examinations clustered into two measurement periods (1998 to 2015 and ≥ 2016).

Results
In INC patients, thoracic proportion indices remained markedly increased, whereas body fat stores remained decreased over the past 25 years (+ 1 vs. below ± 0 z-score, respectively). Their CKD peers presented with overall improved growth, general harmonization of body proportions, and improved body fat stores, while INC patients only presented with an isolated significant increase in leg length over time (∆0.36 z-score). eGFR adjusted for age did not significantly change over the past 25 years in both groups. Alkaline phosphatase (ALP) showed a significant decrease in CKD patients over time, while remaining above normal levels in INC patients.

Conclusions
Disproportionate thoracic shape and impaired body fat stores remain the most characteristic morphological traits in INC patients over the past 25 years, while causal mechanisms remain unclear.

Graphical Abstract
Less restrictions in daily life: a clinical practice guideline for children with cancer
Authors: Stavleu Debbie C. , Mulder Renée L. , Kruimer Demi M. , Kremer Leontien C. M. , Tissing Wim J. E. , Loeffen Erik A. H. ,   On behalf of the social restrictions guideline panel, Beek Laura R. , Evers Janneke H. P. , Hagleitner Melanie M. , Martens Daniëlle H. J. , Noordzij Jeroen G. , Ophorst Ida , Ottens Janneke R. , Plieger Willemijn , Quaak Marjolijn S. W. , Schuerhoff Tirza , Spijkerman Judith , van der Steeg Alida F. W. , van de Wetering Marianne D. , Wolfs Tom F. W. 
Published: June 2024

Abstract
Purpose
In current clinical practice, recommendations regarding restrictions in daily life for children with cancer are often lacking or not evidence-based. Critically reviewing the evidence and formulating recommendations are therefore of great importance as social restrictions (e.g., swimming, school attendance, sports) can impair the quality of life of these children severely. Therefore, our aim was to develop a clinical practice guideline for clinicians, children, and their parents regarding social restrictions in children with cancer.

Methods
A comprehensive multidisciplinary panel was assembled, comprising 21 professionals and patient representatives. A systematic literature review was performed, including dual appraisal of all citations. The GRADE methodology was used to extract, summarize, and assess the evidence. Multiple in-person meetings were held to rank outcomes, discuss evidence, complete evidence-to-decision frameworks, and formulate recommendations. Final recommendations were unanimously supported by all panel members.

Results
Six studies, including 758 children, formed the evidence base for the recommendations. Given the scarcity of the available evidence and various designs of studies in children with cancer, additional evidence was extracted from adult oncology guidelines, and shared expert opinions were utilized. In total, 14 recommendations were formulated of which multiple result in changes in current policy and standard of practice in the Netherlands. Topics covered in this guideline are swimming, having pets, visiting the zoo or farm, performing sports or high-velocity events, attending school or kindergarten, and use of public transport. This guideline is not intended to provide recommendations for patients after end of treatment, for palliative care settings, or for children undergoing a stem cell transplantation.

Conclusions
In this clinical practice guideline, we provide recommendations regarding restrictions in daily life in children with cancer. These include evidence-based recommendations and, in the absence of sufficient evidence, recommendations based on expert evidence. With these recommendations, we provide guidance for clinicians, children, and parents and contribute to improving quality of life for children with cancer.
Advancements in diagnosing oral potentially malignant disorders: leveraging Vision transformers for multi-class detection
Authors: Vinayahalingam Shankeeth , van Nistelrooij Niels , Rothweiler René , Tel Alessandro , Verhoeven Tim , Tröltzsch Daniel , Kesting Marco , Bergé Stefaan , Xi Tong , Heiland Max , Flügge Tabea 
Published: June 2024

Abstract
Objectives
Diagnosing oral potentially malignant disorders (OPMD) is critical to prevent oral cancer. This study aims to automatically detect and classify the most common pre-malignant oral lesions, such as leukoplakia and oral lichen planus (OLP), and distinguish them from oral squamous cell carcinomas (OSCC) and healthy oral mucosa on clinical photographs using vision transformers.

Methods
4,161 photographs of healthy mucosa, leukoplakia, OLP, and OSCC were included. Findings were annotated pixel-wise and reviewed by three clinicians. The photographs were divided into 3,337 for training and validation and 824 for testing. The training and validation images were further divided into five folds with stratification. A Mask R-CNN with a Swin Transformer was trained five times with cross-validation, and the held-out test split was used to evaluate the model performance. The precision, F1-score, sensitivity, specificity, and accuracy were calculated. The area under the receiver operating characteristics curve (AUC) and the confusion matrix of the most effective model were presented.

Results
The detection of OSCC with the employed model yielded an F1 of 0.852 and AUC of 0.974. The detection of OLP had an F1 of 0.825 and AUC of 0.948. For leukoplakia the F1 was 0.796 and the AUC was 0.938.

Conclusions
OSCC were effectively detected with the employed model, whereas the detection of OLP and leukoplakia was moderately effective.

Clinical relevance
Oral cancer is often detected in advanced stages. The demonstrated technology may support the detection and observation of OPMD to lower the disease burden and identify malignant oral cavity lesions earlier.
Reliability and validity of surface EMG assessments combined with isometric muscle strength testing in patients with abdominal rectus diastasis and asymptomatic controls
Authors: Swedenhammar E. , Wahlström O. , Brandt J. D. , Strigård K. , Häger C. , Stark B. , Nyberg A. 
Published: June 2024

Abstract
Purpose
Patients with abdominal rectus diastasis (ARD) may have muscular functional impairments, but clinics lack appropriate objective assessment tools. The aim was to establish the relative and absolute reliability, and convergent validity, of muscular activity using Surface Electromyography (SEMG) during isometric abdominal muscle strength testing in patients with ARD and controls without ARD.

Methods
Twenty-six patients with ARD were matched for age, sex and BMI with controls without ARD. Participants were tested twice during isometric muscular contractions using SEMG located on six abdominal sites. Mean amplitude, fatigue, and recruitment order were analyzed. Relative reliability was evaluated with Intraclass Correlation Coefficients (ICC), while absolute reliability was estimated by calculating the Standard Error of Measurement and Minimal Detectable Change. Convergent validity was addressed in relation to participant characteristics, functional ability, and symptoms.

Results
Mean SEMG amplitude for all abdominal wall muscle contractions showed moderate to excellent relative test–retest reliability, with ICC values ranging from 0.46 to 0.97. In contrast, fatigue and recruitment order displayed poor to moderate relative reliability in both groups. Absolute reliability measures were generally high. A moderate to high convergent validity (ARD: rho-value 0.41–0.70; Controls: rho-value 0.41–0.75) was observed for mean amplitude in relation to a functional sit-to-stand test, abdominal circumference, BMI, back pain, and quality-of-life.

Conclusions
The results of applying SEMG during isometric abdominal muscle support practicing the method in clinics, although additional development is needed with further standardization and more functional testing. Furthermore, the method demonstrates construct validity in patients with ARD and in age- and sex-matched controls.