bluuebunny/crossref_metadata_2025_split huggingface dataset:
Saliva-derived components can enhance the performance of toluidine blue in photodynamic therapy
Authors: Macri Nicolas , Dias Luana Mendonça , Pavarina Ana Claudia , Siqueira Walter L. , Sperandio Felipe Fornias 
Published: February 2025

IntroductionOral Squamous Cell Carcinoma (OSCC) is the most common type of head and neck cancer worldwide. Currently, the most common treatment for OSCC includes a combination of surgery, radiation, and chemotherapy. However, despite the advances made in therapeutic strategies, the prognosis for patients diagnosed with OSCC remains poor, especially at later stages, which emphasizes the need for a novel treatment approach. Photodynamic therapy (PDT) has been employed as stand-alone or adjuvant therapy for OSCC.MethodsThis study investigated the potential of using salivary proteins such as histatin-5 (Hst5) or derived peptides (RR14, DR9/RR14) to perform histatin-mediated PDT. The current literature has shown that histatins have the capacity to increase cellular membrane permeability, which indicates a potential synergistic effect when combined with a photosensitive agent. Toluidine Blue O (TBO) was used as the photosensitizer (PS) singularly combined with salivary peptides RR14, DR9/RR14, and Hst5 protein, and experiments were conducted to assess its biocompatibility and photodynamic effects on human gingival fibroblasts (FGH) and oral squamous cell carcinoma (SCC-25) cell lines.ResultsThe results showed that TBO concentrations below 4 μg/mL were non-cytotoxic to FGH cells, whereas concentrations up to 8 μg/mL were non-cytotoxic to SCC-25 cells. Also, the presence of histatins did not modify the absorption spectrum or photobleaching of TBO, enabling consistent production of reactive oxygen species (ROS) over time and rendering it as a stable and suitable PS for PDT. Further experiments also showed that when TBO was combined with Hst5, the ROS production increased by 186% compared to TBO alone.ConclusionResults suggest that the use of histatin-enhanced PS offer a promising alternative to conventional PDT, potentially improving its outcomes.
Prevalence of depression among primary caregivers of patients with cancer in Africa: a systematic review and meta-analysis study
Authors: Wassie Yilkal Abebaw , Workneh Belayneh Shetie , Mekonen Enyew Getaneh , Ali Mohammed Seid , Techane Masresha Asmare , Wassie Mulugeta , Kassie Alemneh Tadesse , Ahmed Medina Abdela , Simie Tsega Sintayehu , Aemro Agazhe , Zegeye Alebachew Ferede , Tekeba Berhan , Tarik Tamir Tadesse , Nakie Girum , Fentahu Setegn , Melkam Mamaru , Kibralew Getasew , Tadesse Gebresilassie , Gonete Almaz Tefera 
Published: February 2025

BackgroundCancer is one of the main causes of the most extremely stressful events that can elicit emotional reactions such as depression. Cancer patient caregivers are the most involved members of the oncology team and play an important role in patient’s disease management and palliation which may adversely affect their health in the longer run, but many times the caregiver has been overlooked and ignored team. A corresponding systematic review on this topic has not yet been undertaken, even though there have been several studies about depression among primary caregivers of patients with cancer in Africa.MethodsTo find studies, we searched databases such as PubMed, Scopus, Cochrane Library, Science Direct, African Journal Online, and Google Scholar. A Microsoft Excel spreadsheet was used to extract the data, which were then transferred to STATA version 14 for analysis. The statistical heterogeneity was evaluated by using Cochran’s Q and I2 statistics. To identify publication bias, Egger regression tests and funnel plot analysis were used. Sensitivity and subgroup analyses were carried out.ResultsThe current systematic review and meta-analysis comprised all 1983 research respondents from 10 studies. The overall pooled prevalence of depression among primary caregivers of patients with cancer was 47.21% with a 95% CI (31.76, 62.65: I2 = 98.4%). According to subgroup analysis, the pooled prevalence of depression was higher in the studies that used the back depression inventory screening tool (63.95%) (95% CI: 58.76, 69.13). Additionally, we observed a high pooled prevalence of depression in existing studies conducted in Kenya (62.7%) (95% CI: 56.45, 68.95). Finally, a greater prevalence of depression was found among primary caregivers of children with cancer (64.61%) (95% CI: 58.19, 71.03).Conclusion and recommendationsThe current systematic review and meta-analysis showed that depression was prevalent among primary caregivers of patients with cancer in Africa. The study also highlighted variability in prevalence based on country, method of depression assessment, and population subgroups. Therefore, public health interventions targeting the mental health of caregivers should be promoted. Priority should be given to those who care for children.
A network analysis study on the relationship between generalized anxiety symptoms, big five personality and perceived social support of Chinese residents during COVID-19
Authors: Yang Jiaqin , Man Xiaotong , Liu Chunlei 
Published: February 2025

IntroductionUnder the background of COVID-19, people’s mental health problems are concerned by researchers. Network analysis is a new method of exploring the interactions between mental health issues at the symptom level. This study investigates the network structure of generalized anxiety symptoms among Chinese residents during the COVID-19 pandemic from the perspective of “society-family-personality,” and explores its relationship with the Big Five personality traits and perceived social support.MethodsA multi-stage random sampling cross-sectional survey was conducted in 120 cities across China Mainland from July 10, 2021 to September 15, 2021, based on the PBICR database. The Big Five Scale (BFI-10), Perceived Social Support Scale (PSSS), and Generalized Anxiety Scale (GAD-7) were used for measurement. Pearson correlation analysis was used to examine the variables mentioned in this research, and network analysis was used to estimate the psychopathological network of the three variables.ResultsA total of 11,031 subjects were included in the study, with 17% of individuals suffering from severe generalized anxiety symptoms. The results showed a correlation between the three research variables, and it was found that perceived social support in both dimensions and agreeableness of the Big Five personality traits were at the center of the network, with a significant impact on the overall network. There is a positive correlation between agreeableness and family support, but a negative correlation with generalized anxiety symptoms. Agreeableness serves as an indicator linking the other two variables; No significant gender differences were found through gender network testing.ConclusionAccording to this study, we believe that interventions in family atmosphere and social interaction can be used to prevent symptoms of generalized anxiety disorder. The limitation of this study is that it cannot determine the causal relationship between variables and its generalizability in general contexts has not been confirmed. Future research can further explore its directionality based on this study and consider the influence of cultural factors to extend its applicability to other backgrounds.
Mapping of long COVID condition in India: a study protocol for systematic review and meta-analysis
Authors: Jain Nidhi , Shah Komal , Chauhan Roshani , Gupta Abhishek , Arora Priyanka , Saxena Deepak , Mavalankar Dileep 
Published: February 2025

BackgroundThe COVID-19 pandemic has reported significant alarming aftereffects experienced by some individuals following acute sequelae of SARS-CoV-2 infection, commonly referred to as long COVID. Long COVID is a set of symptoms that remain for weeks or months, after the initial phase of COVID-19 infection is ended.ObjectiveThis study protocol outlines the methodology of a systematic review followed by a meta-analysis to comprehensively assess the chronic effects of COVID-19 infection on the Indian population and determine the likely risk factors connected to the development and persistence of long COVID.MethodologyThis study will employ comprehensive search through a custom-made search strategy across significant databases (PubMed, MEDLINE etc.) and grey literature to identify related literature from January 2020 to December 2023. A systematic review and meta-analysis will be conducted to synthesize data from various studies. The data synthesis will involve a comprehensive narrative and tabular presentation of outcome data from included studies, focusing on long-term effects of COVID-19 infection in Indian population. A meta-analysis will be conducted contingent upon the availability and suitability of data. If sufficient and comparable quantitative data are identified across the included studies, statistical synthesis will be undertaken. Subgroup and sensitivity analyses will manage confounders, while MedCalc software will facilitate a meta-analysis to assess pooled data. Publication bias will be evaluated using statistical tests to ensure the integrity of the findings. In the absence of adequate data, a narrative synthesis will be performed to summarize the findings systematically and transparently.ConclusionThe anticipated findings will contribute to a refined understanding of this condition and its lingering symptoms, guiding healthcare interventions and future research endeavors to mitigate the impact of long COVID in the Indian population.
Biomimética na melhoria da dispersão de sementes da Bertholletia excelsa na Amazônia
Authors: Benedito Lucas Henrique , Foppa Janecler 
Published: February 2025

Este artigo acadêmico aborda o papel fundamental desempenhado pela cutia (Dasyprocta spp.) na dispersão de sementes de castanha-do-Pará (Bertholletia excelsa) em ecossistemas tropicais da América do Sul, com uma atenção especial na região amazônica. A castanha-do-Pará é uma espécie de árvore produtora de sementes comestíveis, altamente valorizadas por suas propriedades nutricionais e econômicas. A cutia, por sua vez, é um pequeno roedor que habita essas áreas tropicais e tem uma estreita relação ecológica com a castanheira-do-Pará. O estudo analisa como a cutia desempenha um papel central na dispersão das sementes da castanha-do-Pará, promovendo a regeneração da espécie vegetal e a manutenção da biodiversidade na floresta amazônica através do uso da tecnologia e biomimética.
QUALIDADE DA EDUCAÇÃO E SUA RELAÇÃO COM A FORMALIZAÇÃO NO MERCADO DE TRABALHO DO ESTADO DE MINAS GERAIS
Authors: Costa Ana Karolina Mendes Mathias , Teixeira Evandro Camargos 
Published: February 2025

Este estudo tem como objetivo analisar a relação entre a qualidade da educação, tendo como proxy o Índice de Qualidade da Educação do 3º ano do ensino médio, e a formalização no mercado de trabalho do estado de Minas Gerais entre os anos 2013 e 2019. Para tal, são utilizadas informações provenientes do Índice Mineiro de Responsabilidade Social (IMRS) e estimação de um modelo econométrico com dados em painel dinâmico. Os resultados indicam a existência de relação direta entre o Índice de Qualidade da Educação e a taxa de emprego formal. Dessa forma, atesta-se que indivíduos com desempenho acadêmico mais elevado desenvolvem competências essenciais, que elevam a inserção no mercado de trabalho formal. A partir dos resultados encontrados, políticas públicas com ênfase no aprimoramento da qualidade da educação podem constituir uma forma eficaz de elevar o nível de formalização no mercado de trabalho, contribuindo no processo de desenvolvimento econômico mineiro.
Diagnosis dan Penatalaksanaan Mesiodens pada Anak: Laporan Kasus
Authors: Maryam Khaulah , Jeffrey Jeffrey 
Published: February 2025

Abstract: Mesiodens are supernumerary teeth or extra teeth that grow between two maxillary central incisors, often found in children with mixed dentition. Appropriate management in cases of mesiodens needs to be carried out, because mesiodens can cause various complications. We reported a 13-year-old boy who came to RSGM Universitas Jenderal Achmad Yani (Unjani) with complaints of messy front teeth and an excess tooth appearing between the two incisors of the upper jaw. The patient underwent treatment in the form of mesiodens extraction, followed by continuous observation for one year after treatment. Evaluation one year after treatment showed excellent results. It is recommended that extraction of mesiodens be carried out as soon as possible. Removal of the mesiodens at a young age will minimize the need for orthodontic therapy and additional surgical intervention in the future.
Keywords: tooth extraction; mesiodens; supernumerary teeth

Abstrak: Mesiodens adalah supernumerary teeth atau gigi berlebih yang tumbuh di antara kedua insisif sentral rahang atas, sering dijumpai pada anak dengan periode gigi campuran. Penatalaksanaan yang tepat pada penanganan kasus mesiodens perlu dilakukan, karena mesiodens dapat menyebabkan beragam komplikasi. Kami melaporkan kasus seorang anak laki-laki berusia 13 tahun datang ke RSGM Universitas Jenderal Achmad Yani (Unjani) dengan keluhan gigi depannya berantakan dan adanya gigi berlebih yang muncul di antara kedua gigi seri rahang atasnya. Pasien dilakukan perawatan berupa ekstraksi mesiodens, dilanjutkan dengan observasi berkelanjutan selama satu tahun pasca perawatan. Evaluasi satu tahun setelah perawatan menunjukkan hasil yang sangat baik. Ekstraksi mesiodens direkomendasikan untuk dilakukan sesegera mungkin. Pencabutan mesiodens pada usia muda akan meminimalkan kebutuhan terapi ortodontik maupun intervensi bedah tambahan di kemudian hari.
Kata kunci: ekstraksi gigi; mesiodens; supernumerary teeth
Dilema Etik bagi Tenaga Kesehatan dalam Menentukan Pilihan Tindakan Medis Berdasarkan Prinsip Berbuat Baik (Beneficence) atau Prinsip Otonomi (Autonomy)
Authors: Saputra Warren , Djai Yen Liauw 
Published: February 2025

Pendahuluan: Tujuan utama profesi kedokteran adalah mengatasi penderitaan dan memulihkan kesehatan pasien melalui praktik medis. Praktik ini didasarkan pada etik dan moral. Prinsip beneficence mengharuskan dokter bertindak demi kebaikan pasien, sementara prinsip autonomy menekankan hak individu untuk membuat keputusan sendiri. Prinsip ini adalah kewajiban prima facie yang dalam situasi konflik, harus dinilai bobot masing-masing berdasarkan konteks untuk menentukan tindakan terbaik bagi pasien.

Metodologi: Telaah pustaka dilakukan dari sumber referensi, yaitu PubMed. Artikel yang diperoleh diseleksi sesuai dengan kriteria inklusi, dan hasil akhir diperoleh 10 artikel.

Hasil dan Pembahasan: Beneficence dan autonomy adalah tugas moral utama dalam bioetika, dan interaksi antara keduanya membutuhkan pertimbangan yang cermat dalam menentukan cara terbaik untuk bertindak. Dalam beberapa kasus, seperti praktik alergi, dilema etik dapat muncul. Pendalaman ilmu etik dan penggunaan komunikasi yang sesuai dengan soft paternalismemenjadi pilihan dalam solusi masalah tersebut.

Kesimpulan: Dalam praktik medis, prinsip beneficence dan autonomy sering menimbulkan dilema, terutama ketika preferensi dokter untuk berbuat baik bertentangan dengan keputusan medis pasien, seperti pada kasus pengekangan fisik, bedah plastik, pasien anak, dan pasien jiwa. Percakapan persuasif dapat membantu mencapai perawatan yang sesuai dengan tujuan pasien, tanpa mengorbankan prinsip beneficence dan autonomy.

Kata kunci: Autonomy, Beneficence, Dilema Etik, Etika Kedokteran, Prinsip Bioetika
Tinjauan Etik Rumah Sakit Berkontribusi Dalam Limbah Makanan
Authors: Yen Liauw Djai , Wea Brigitta Yuliana , Tholib Clemarie Natasha , Mai Roy , Rasyiqah Fajrina Rizki , Yurike Vony , Ongga Leonardo 
Published: February 2025

Pendahuluan: Sekitar sepertiga produksi makanan yang diproduksi per tahun dibuang dan menjadi limbah makanan yang terjadi di seluruh dunia dan dapat mempengaruhi bidang sosial, keuangan dan lingkungan dalam skala global. Menurut Williams dan Walton, limbah makanan yang dihasilkan rumah sakit dua sampai tiga kali lebih besar dibandingkan di bidang pelayanan lainnya. Limbah makanan dari rumah sakit dipengaruhi oleh faktor internal dan eksternal. Limbah makanan yang berasal dari rumah sakit yang diolah dan didaur ulang akan menghasilkan metana dan emisi CO2 yang turut menambah pemanasan global.
Metodologi: Pencarian literatur dilakukan menggunakan database Pubmed dan Google scholar dengan kata kunci utama “limbah makanan”, “rumah sakit”, “lingkungan”, dan “etik”. Artikel yang digunakan mencakup publikasi hingga tahun 2024 dan berbahasa Indonesia dan Inggris.
Pembahasan: Literatur ini menunjukkan bahwa sayuran sering menjadi jenis makanan yang paling tersisa di rumah sakit karena faktor rasa, suhu, dan tampilan yang kurang menarik. Karakteristik pasien juga mempengaruhi limbah makanan, seperti usia, jenis kelamin, tingkat pendidikan, serta kondisi kesehatan. Strategi untuk mengurangi limbah makanan meliputi penyajian menarik, sistem room service, dan inovasi biokonversi dengan larva BSF. Negara Indonesia sendiri memiliki beberapa kebijakan untuk mengurangi limbah makanan, namun masih diperlukan manajemen yang lebih terarah.
Kesimpulan: Limbah makanan di rumah sakit berdampak pada lingkungan, sosial, dan finansial, dipengaruhi oleh kualitas makanan, karakteristik pasien, dan lingkungan perawatan. Strategi pengurangan utama termasuk peningkatan penyajian makanan, layanan fleksibel seperti room service, biokonversi dengan larva BSF, dan daur ulang. Indonesia memiliki kebijakan untuk mengurangi limbah, tetapi diperlukan regulasi yang lebih spesifik untuk rumah sakit
Stress-strain state of stone cross vaults
Authors: Zimin S. S. 
Published: February 2025

Introduction. The calculation of stone vaults in historical buildings employs an approach in which vaults are treated as elements “assembled” from three-hinged, two-hinged, and hingeless arches, with the determination of forces being carried out according to general rules of structural mechanics. However, the capabilities of such an approach to analyze spatially working structures (cross vaults) made of materials exhibiting strength anisotropy (masonry) are extremely limited.Aim. To establish the regularies in the formation of the stress-strain state parameters of a stone cross vault under uniformly distributed loads, as well as the influence of the strength anisotropy of masonry on the strength of the vault.Materials and methods. The analysis of the stress-strain state of the stone cross vault was performed using a high-level finite element modeling software in a solid spatial homogeneous formulation. The study assessedthe impact of the strength anisotropy of masonry and the non-uniaxiality of the stress state in specific areas of the vault on its overall strength.Results. The most unfavorable stress state was found to occur in the central area of the cross vault beneath the axes of the formwork, where biaxial tension of equal intensity is formed, characterized by extremely low resistance. The stress-strain state is dependent on the ratio of rise f to span L (f/L). The strength of the stone cross vault was revealed to depend, among other things, on the orientation of forces relative to mortar joints in the masonry; significant non-uniaxiality of forces is observed in specific areas.Conclusions. The most significant factor affecting the formation of the stress-strain state in a stone cross vault, in addition to its span and thickness, is the ratio of rise f to span L (f/L). Strength analysis of cross vaults should consider the orientation of forces relative to mortar joints while accounting for the non-uniaxiality of forces in specific areas.
Engineering survey of stone buildings after fire exposure
Authors: Kurlapov D. V. 
Published: February 2025

Introduction. Engineering survey forms a basis for making informed decisions regarding the operation of stone structures following exposure to high temperatures and fire.Aim. To determine the residual bearing capacity and to specify methods for reinforcing stone structures after a fire.Materials and methods. The impact of fire on stone structures depends on the size and material of the stone, the spatial arrangement of the walls, the thermal and prolonged effects of the fire, and the firefighting methods employed.Results. Stone buildings constructed in the late 19th and first half of the 20th century were predominantly 2–7 stories high, while those built in the second half of the 20th century ranged from 5 to 14 stories. The walls were primarily made of solid and hollow ceramic and sand-lime bricks. The mortar used for wall masonry in the late 19th century and throughout the 20th century was cement-lime based. The thickness of walls built in the late 19th to early 20th century typically comprised 2–2.5 bricks, while after the 1920s, it was generally two bricks. When exposed to thermal effects of a fire, ceramic brick masonry at temperatures up to 800 °C experiences spalling of the stone to a depth of no more than 5 mm, with vertical and inclined surface cracks appearing, while the bearing capacity remains unaffected. At temperatures between 800 and 1000 °C, fire damage penetrates to a depth of 5–10 mm, resulting in vertical and inclined cracks extending no more than two courses of masonry, with wall bulging not exceeding 1/6 of their thickness. The bearing capacity of the masonry decreases by 15–20 %. When masonry walls and columns made of ceramic bricks are heated from 1000 to 1200 °C, damage exceeds 10 mm in depth, with vertical and inclined cracks extending over two courses of masonry, and bulging of walls reaching one-third or more of the masonry thickness. The bearing capacity of the masonry declines by more than 20 %.Conclusions. All cracks must be classified according to their causes: overloading of wall sections, thermal effect, and uneven foundation settlement. This necessitates an inspection of wall sections adjacent to areas affected by fire. The type and condition of the mortar in the masonry are to be assessed. For comparison, joints in masonry adjacent to fire-damaged areas should be examined. The design resistance of brick masonry subjected to fire exposure, after cooling, is considered equal to the design resistance prior to the fire multiplied by a coefficient for reduced bearing capacity kmc.