bluuebunny/crossref_metadata_2025_split huggingface dataset:
Leisure activities in adolescents with headache
Authors: Oksanen A , Metsähonkala L , Anttila P , Aromaa M , Jäppilä E , Viander S , Salminen J , Helenius H , Sillanpää M. 
Published: August 2010

Abstract Aim: To investigate the association between different types of headache and leisure activities in 13‐y‐old schoolchildren. Methods: A population‐based, cross‐sectional study was performed through face‐to‐face interviews with age‐matched cohorts with headache and asymptomatic controls. The present study comprised 59 children with migraine, 65 with episodic tension‐type headache (TTHA) and 59 headache‐free controls. In the interview, besides questions concerning headache, the children were asked open and structured questions about the type and amount of their leisure activities. Results: Children with migraine spent more time in sports activities than children with episodic tension‐type headache or children without headache (test for trend, p<0.01; migraine: OR 1.4, 95% CI 1.1–1.9; tension‐type headache: OR 0.9, 95% CI 0.7–1.1). The type of leisure activity was not significantly associated with headache type (p>0.05). Children with both migraine and episodic tension‐type headache used computers more often than children without headache (test for trend, p<0.05; migraine: OR 1.2, 95% CI 1.1–1.5; tension‐type headache: OR 1.3, 95% CI 1.1–1.5). Conclusion: This study provides additional data on the activity status and headache complaints in adolescents. The results indicate that frequent computer use is associated with both tension‐type headache and migraine, and intensive overall sports activities are characteristic of adolescents with migraine.
Brunner's gland adenoma: A rare cause of vomiting
Authors: Urganci Nafiye , Arapoglu Müjde , AkyIldIz Basak , Calay Zerrin , Nuhoğlu Asiye 
Published: August 2010

AbstractUpper gastrointestinal system adenoma is generally seen amongst elderly patients and quite rarely seen during the childhood. A 14‐y‐old female patient was referred to our hospital with complaints of vomiting and abdominal pain. She had been followed up for 6 y with the diagnosis of familial intermittent fever and chronic renal failure due to amyloidosis. Endoscopic examination of the upper gastrointestinal system revealed mild hyperaemia in the corpus and antrum, and a polyp of 0.5×0.5 cm with an ulcerated and pedunculated top in the bulbus. Brunner's gland adenoma was diagnosed by the histopathological examination of the lesion following polypectomy. Conclusion: Brunner's gland adenoma is usually asymptomatic; however, it may reveal clinical findings such as obstruction, bleeding or intussusception, especially in uraemic patients. Thus, we would like to emphasize that, in patients with chronic renal failure and acute onset vomiting and abdominal pain, Brunner's gland adenoma should be considered in the differential diagnosis.
Infection and early atherosclerosis: Does the evidence support causation?
Authors: Liuba Petru , Pesonen Erkki 
Published: August 2010

AbstractAlthough clinical manifestations of atherosclerotic coronary heart disease occur in adult life, the initial stages of its development commence in childhood. Therefore, elucidating the pathogenesis of early atherosclerosis and identifying the network of risk factors have become fundamental priorities for both cardiovascular healthcare providers and scientists. There is mounting evidence from both human studies and animal experiments that infectious pathogens could be implicated in atherosclerosis development. The vulnerability of the arterial wall to the adverse effects of infection is probably augmented when additional risk factors and/or certain proatherogenic genetic profiles are also present. The precise mechanisms whereby infection, alone or in synergy with conventional cardiovascular risk factors, could contribute to atherosclerosis are not fully understood. Conclusion: Injury to the vascular endothelium, which could be elicited by infection through inflammatory, metabolic, autoimmune, and pathogen‐related mechanisms, might be a central link between infection and early atherosclerosis.
Management, asthma control and quality of life in Swedish adolescents with asthma
Authors: Hasselgren Mikael , Gustafsson D , Ställberg B , Lisspers K , Johansson G 
Published: August 2010

Abstract Aim: In Sweden, paediatricians or general practitioners treat most adolescents with asthma. This study compares management, treatment goals and quality of life for adolescents aged 15–18 y in paediatric or primary care. Material and methods: A random sample of patients answered a disease‐specific and a quality‐of‐life (MiniAQLQ) questionnaire. Results: The 146 adolescents in paediatric care had more years with asthma, better continuity of annual surveillance, higher use of inhaled steroids and a stated better knowledge of their asthma than the 174 patients in primary care. No difference could be detected in asthma control or quality of life. Of all 320 adolescents, approximately 20% had woken at night due to asthma symptoms during the last week. About 15% had made unscheduled, urgent care visits and a third had used short‐acting beta‐agonist relievers more than twice a week. Quality‐of‐life scores were high and similar in both settings. Conclusions: Swedish adolescents with asthma are managed and treated somewhat differently in paediatric and primary care but with equal and, for the most part, satisfying results. The difference between the two settings probably reflects both differences in severity of asthma and different treatment traditions. For all adolescents, better fulfilment of goals regarding symptoms and exacerbations would be desirable, whereas a good quality of life including normal physical activity seems to have been achieved.
Varicella zoster virus antibody titers after intravenous zoster immune globulin in neonates, and the safety of this preparation
Authors: Murguía‐de‐Sierra Teresa , Villa‐Guillén Mónica , Villanueva‐García Dina , Molina Antide , Juárez‐Chávez Alejandra , Leistikow Elizabeth A 
Published: August 2010

Abstract Aims: 1) To assess the safety of intravenous varicella zoster virus hyperimmune globulin G (IV‐VZVIG) in neonates; 2) measure varicella zoster virus‐specific IgG antibody (VZVIG) changes in newborn IV‐VZVIG recipients. Methods: Eighteen neonatal intensive care unit (NICU) neonates with varicella exposure were given 1 ml/kg (43 International Units (IU)/kg) Varitect® IV‐VZVIG. Serum VZVIG titers were assayed in neonatal recipients 0, 1, 7, 14, 21, 28, and 35 d after IV‐VZVIG. Also, serum samples for VZV‐IgM antibody determinations were obtained at 4 wk post‐infusion. Results: No varicella developed in the 18 infants. Infusion of 1 ml/kg (43 IU/kg) IV‐VZVIG was generally safe. The IV‐VZVIG dose resulted in seroconversion of a non‐immune newborn. Five infants had low basal VZVIG titers, and two of them had a 0.6‐log10 increase at 24 h post‐infusion. Neonatal VZVIG titers (mean±SEM in log10) before IV‐VZVIG and after by 1, 7, 14, 21, 28, and 35 d were 2.22±0.15, 2.17±0.17, 2.02±0.12, 0.87±0.2, 1.09±0.19, 2.33±0.07, and 2.16±0.1, respectively. Conclusions: One ml/kg (43 IU/kg) IV‐VZVIG was generally safe. Our neonatal mean VZV‐immune status did not significantly increase after the 1 ml/kg (43 IU/kg) IV‐VZVIG dose, although no varicella developed and it caused a VZV‐specific seroconversion.
Twenty‐year dynamics in adiposity and blood lipids of Greek children: Regional differences in Crete persist
Authors: Manios Yannis , Magkos Faidon , Christakis George , Kafatos Anthony G 
Published: August 2010

Abstract Aim: To examine whether secular trends in adiposity and blood lipid profile of Greek children manifested equally among individuals from urban and rural provinces. Methods: Cretan boys (aged 12.1±2.3 y) from urban and rural areas of Crete were recruited in 1982 (n=277 and 251, respectively) and 2002 (n=440 and 180, respectively). Height, weight, and body mass index (BMI), as well as plasma lipid concentrations were measured and compared across cohorts (1982 vs 2002) and regions (urban vs rural) by two‐way analysis of covariance (adjusted for age) with interaction. Results: Temporal changes in height (positive), weight (positive), and BMI (positive) manifested equally in children from urban and rural provinces, as no interaction was detected. Similar results were obtained for triacylglycerol (positive), low‐density lipoprotein cholesterol (LDL‐C, positive) and high‐density lipoprotein cholesterol (negative) concentrations. A significant interaction was observed only for total cholesterol (TC), which increased from 1982 among rural (by 6.2%, p<0.05) but not among urban boys. In all other instances, regional differences in 1982 persisted in 2002. More specifically, children from urban provinces were taller, heavier, and had higher BMI values than those from rural areas, while they also had higher LDL‐C concentrations, whether nowadays or 20 y ago. Regional differences in TC in 1982 were not apparent in 2002. Conclusion: These findings suggest that changes in anthropometric characteristics and plasma lipids during the past 20 y have occurred largely in parallel among urban and rural Cretan children, and they emphasize the importance of developing a common national strategy for the prevention and treatment of childhood obesity in Greece.
The effect of maternal, umbilical cord and placental malaria parasitaemia on the birthweight of newborns from South‐western Cameroon
Authors: Eric Akum Achidi , Kuoh Anchang J , Minang Jacob T , Achimbom Boyo M , Ahmadou Mokube J , Troye‐Blomberg Marita 
Published: August 2010

Abstract Aim: The impact of maternal, umbilical cord and placental malaria parasitaemia on the incidence of low birthweight was investigated in pregnant women reporting for delivery at the Mutengene Maternity Centre, Fako Division, South West Province, Cameroon. Methods: The malaria parasitaemia status of 770 umbilical cords, parturient women and placental impression smears were determined by light microscopy using blood samples collected between June 1999 and September 2001. The birthweights (BW) of the newborns were recorded soon after delivery. Results: The results show that malaria parasites were present in the blood samples of 57 out of 730 (7.8%), 233/711 (32.8%) and 248/735 (33.7%) cord, maternal and placental biopsies respectively. Low birthweight (LBW) was recorded in 72 (9.6%) newborns, and the incidence was higher in primiparae. Newborns of mothers who had malaria parasites in their peripheral blood (12.4%) had a higher incidence (p=0.014) of LBW when compared with malaria parasite‐free mothers (6.8%). Similarly, neonates born from malaria‐positive placentas (13.5%) had a significantly higher incidence of LBW (p=0.006) than those from parasite‐negative placentas (6.8%). Furthermore, newborns of malaria parasite‐positive mothers, umbilical cords, placentas and primiparae had lower mean birthweight than malaria‐negative mothers, placentas, umbilical cords and multiparae. Conclusion: We suggest that parity and maternal and placental malaria parasitaemia at delivery have an important negative impact on birthweight, especially in first pregnancies. This observation emphasizes the need for appropriate aggressive intervention strategies such as the use of insecticide‐treated bed nets or intermittent preventive treatment to control malaria in pregnancy in the study area.
Prevalence and determinants of exclusive breastfeeding during hospital stay in the area of Athens, Greece
Authors: Pechlivani Fani , Vassilakou Tonia , Sarafidou Jasmin , Zachou Themis , Anastasiou Costas A , Sidossis Labros S 
Published: August 2010

Abstract Aim: To assess breastfeeding practices, focusing on the prevalence and the determinants of exclusive breastfeeding during hospital stay. Methods: A cross‐sectional study of 1603 healthy women, who delivered healthy infants weighing more than 2500 g, was conducted in the area of Athens, Greece. Participants completed a self‐administered questionnaire on the day they were discharged from the maternity ward. Classification of breastfeeding and recall period from birth to discharge were in accordance with the WHO criteria. Hierarchical logistic regression analysis was used to study determinants of exclusive breastfeeding initiation. Results: Breastfeeding initiation was reported by 96.1% of the participants. However, exclusive breastfeeding was initiated only in 19.1% and predominant breastfeeding in 7.2% of the cases. The univariate analysis showed that maternal younger age, low educational level, unemployment, vaginal delivery, infant birthweight >3000 g, multiparity, early initiation of breastfeeding, rooming‐in and awareness on the existence of breastfeeding centres were associated with higher rates of exclusive breastfeeding. Logistic regression analysis revealed that rooming‐in (OR 3.72, p<0.01), demand feeding (OR 2.18, p<0.01), type of delivery (OR 1.61, p<0.01) and the source of information received about breastfeeding are more important determinants of exclusive breastfeeding than the socio‐demographic parameters. Conclusions: Exclusive breastfeeding during hospital stay in the area of Athens is low. Demand feeding and rooming‐in positively influence exclusive breastfeeding initiation, while caesarean section and information by mass media have a negative impact.
Mother–child health research (IRN‐MCH): Achievements and prospects of an international network
Authors: de Thé Guy , Zetterström Rolf 
Published: August 2010

AbstractThe Inter‐Academy Panel (IAP) is critical about the scarce support to mother–child health (MCH) research in developing countries. At the request of the IAP, a group of members of the French and Swedish Academies of Science have arrived at the conclusion that an efficient network between scientists in resource‐poor and industrialized countries will facilitate MCH research in developing countries. The priorities for such a network have been listed as follows:

The present organization for the MCH website at the Pasteur Institute in Paris should be adapted to better promote collaboration between scientists from industrialized and developing countries.
To provide short‐term courses for young scientists from developing countries in the design of research protocols, and in the writing of scientific reports and manuscripts.
To organize workshops on various topics of relevance for MCH in developing countries in order to create new research networks for scientific collaboration between industrialized and resource‐poor countries.
To establish collaboration between non‐governmental organizations (NGOs) that support MCH research in developing countries.

Topics for such collaborative studies and the way in which they may be performed are summarized.
Beyond the insiders' circle: Disseminating the results of adolescent health surveys
Authors: Michaud Pierre‐Andre , Jeannin Andre 
Published: August 2010

AbstractAdolescent health surveys, like those for other segments of the population, tend to remain in the hands of researchers, where they can have no real impact on the way critical health issues are dealt with by policy makers or other professionals directly connected to young people in their everyday work. This paper reviews important issues concerning the dissemination of survey results among professionals from various fields. The content, length and wording of the messages should be tailored to the audience one wants to reach as well as the type of channels used for their diffusion. Survey data sets can be used to select priorities for interventions: ad hoc presentations, attractive summaries and brochures, or even films expressing young peoples' opinions have been used by European public health professionals to make data sets usable in various local, regional and national contexts. Conclusion: The impact of these diffusion strategies is, however, difficult to assess and needs to be refined. The adequate delivery of survey findings as well as advocacy and lobbying activities require specific skills which can be endorsed by specialized professionals. Ultimately, it is the researchers' responsibility to ensure that such tasks are effectively performed.
Expanding screening for rare metabolic disease in the newborn: An analysis of costs, effect and ethical consequences for decision‐making in Finland
Authors: Autti‐Rämö Ilona , Måkelå Marjukka , Sintonen Harri , Koskinen Hanna , Laajalahti Liisa , Halila Ritva , Kååriåinen Helena , Lapatto Risto , Nåntö‐salonen Kirsti , Pulkki Kari , Renlund Martin , Salo Matti , Tyni Tiina 
Published: August 2010

Abstract Aim: Currently, the only metabolic disorder that newborns are screened for in Finland is congenital hypothyroidism. A proposal to start a pilot study on screening for other rare metabolic diseases using tandem mass spectrometry prompted a health technology assessment project on the effect and costs of expanded newborn screening programme options. Method: A modelling study using data from current published studies, healthcare registers and expert opinion. Results: The annual running cost of screening 56 000 newborns for the chosen five disorders (congenital adrenal hyperplasia, medium‐chain acyl‐CoA dehydrogenase deficiency [MCADD], long chain 3‐hydroxyacyl‐CoA dehydrogenase deficiency [LCHADD], phenylketonuria [PKU] and glutaric aciduria type 1 [GA 1]) was estimated to be €2.5 million or €45 per newborn when starting costs were included. The costs per quality‐adjusted life year (QALY) gained are a maximum of €25 500. Prevention of severe handicap in one newborn would reduce the costs to a maximum of €18 000 per QALY gained. Conclusions: Expanding the Finnish neonatal screening programme would require a new organization. The cost‐effectiveness, resources, ethics and equity need to be considered when deciding in favour of or against starting a new screening programme.
Auxological data in patients clinically suspected of Sotos syndrome with NSD1 gene alterations
Authors: de Boer Lonneke , Le Cessie Saskia , Wit Jan M 
Published: August 2010

Abstract Aim: Nuclear receptor‐binding SET domain‐containing protein 1 (NSD1) gene mutations and deletions (NSD1+/−) are the major cause of Sotos syndrome. The aim was to investigate which auxology parameters relate to NSD1+/− in patients clinically suspected of Sotos syndrome. Methods: In 32 patients clinically suspected of Sotos syndrome, we compared auxology parameters between NSD1+/− patients and patients without NSD1 gene alterations (NSD1+/+). The statistical performance of these parameters to predict NSD1+/− was assessed. Results: Arm span‐for‐height standard deviation score (SDS) and hand length SDS were significantly higher in NSD1+/− patients. Conclusion: Arm span for height and hand length are discriminating parameters between NSD1+/− and NSD1+/+.
Erythrocyte membrane acetylcholinesterase, Na+, K+‐ATPase and Mg2+‐ATPase activities in patients with classical galactosaemia
Authors: Tsakiris Stylianos , Michelakakis Helen , Schulpis Kleopatra H. 
Published: August 2010

Abstract Background: Classical galactosaemia is commonly presented by high blood galactose (Gal) and galactose‐1‐phosphate (Gal‐1‐P) levels followed by mental retardation, seizures, etc. dependent on the mutation of the patients. Aim: To evaluate Gal and Gal‐1‐P in the blood of patients and to correlate their levels with their erythrocyte membrane acetylcholinesterase (AChE), Na+,K+‐ATPase and Mg2+‐ATPase activities. Methods: Blood was obtained from nine patients on poor diet (group B) followed by a 30‐d strict diet (group A) and controls (group C) in order to evaluate Gal and Gal‐1‐P in Guthrie cards and to correlate their concentrations with the above enzyme activities, which were measured spectrophotometrically. Results: With the patients on a “loose” diet, AChE, Na+,K+‐ATPase and Mg2+‐ATPase activities were found to be decreased, as compared with those on strict diet and controls. Significantly (p<0.01) inverse correlation coefficients of the enzyme activities were found with Gal‐1‐P levels. Conclusion: (a) AChE, Na+,K+‐ATPase and Mg2+‐ATPase activities were determined to be decreased in poorly controlled patients with classical galactosaemia. (b) The enzyme activities were inversely correlated with the Gal‐1‐P blood levels. (c) Since Na+,K+‐ATPase in the erythrocyte membranes is the isomer of Na+,K+‐ATPase distributed in many tissues and in the brain, evaluation of the enzyme activity in the erythrocytes could be a useful peripheral marker of Gal‐1‐P toxicity.
Fracture and non‐fracture pain in children with osteogenesis imperfecta
Authors: Zack Philip , Franck Linda , Devile Catherine , Clark Christine 
Published: August 2010

Abstract Aim: To describe and compare the characteristics of acute fracture and chronic non‐fracture pain in children with osteogenesis imperfecta (OI). Methods: A questionnaire about fracture‐related pain and prospective 7‐d diary about non‐fracture‐related pain was completed by a random sample of 35 children aged 5–18 from a UK national OI service. Main outcome measures included pain intensity, location, frequency, quality, coping strategies and analgesia use. Results: Most children reported moderate to severe pain associated with fractures and less intense non‐fracture pain (p<0.001). Pain intensity was significantly higher in the children who used analgesics (p<0.001). The quality of fracture and non‐fracture pain differed only for affective words, which were less frequently used to describe non‐fracture pain (p=0.002). More activities of daily living (ADLs) were affected by fracture pain than by non‐fracture pain (p<0.001). Children reported more frequent use of approach coping strategies with fracture pain and more frequent use of distraction for non‐fracture pain (p<0.01). There were no differences in non‐fracture pain intensity, duration, quality, effect on ADLs or coping between children who did or did not take bisphosphonates. Conclusions: Pain is a common occurrence for children with OI and is both acute and chronic in nature, interfering with children's daily living activities. OI pain may not be optimally treated because many children experienced moderate to severe pain despite use of analgesics and/or coping strategies.
Biomarkers in lysosomal storage diseases: a review
Authors: Cox TM 
Published: August 2010

AbstractA biomarker is generally an analyte that indicates the presence or extent of a biological process, which is itself directly linked to the clinical manifestations and outcome of a particular disease. An ideal biomarker provides indirect but ongoing and specific determinations of disease activity. These characteristics emphasize the value of surrogate biomarkers for non‐invasive and detailed monitoring to demonstrate the efficacy of orphan drugs in clinical trials. The emergence of novel laboratory methods has facilitated the search for biomarkers in lysosomal storage diseases (LSDs), by allowing the systematic identification of molecules whose expression is altered as a result of the primary storage pathology. In Gaucher disease, for example, a chemokine, CCL18, has been identified as a biomarker for clinical development that reflects disease severity and response to treatment. Conclusion: New methods for the identification of novel biomarkers have the potential to provide mechanistic insights into the molecular pathogenesis of LSDs, including Fabry disease and Gaucher disease.