bluuebunny/crossref_metadata_2025_split huggingface dataset:
Different responses to two types of 5-fluorouracil prodrugs in combination with interferon-alpha in pulmonary metastases of renal cell carcinoma: a case report
Authors: Morita Tatsuo , Nakano Kazuhiko , Yuzawa Masayuki 
Published: November 2009

Abstract
A 66-year-old Japanese man with pulmonary metastases of renal cell carcinoma found 8 months after radical nephrectomy was treated with interferon-alpha and tegafur-uracil. Since it failed to achieve tumor responses resulting in progression, he was given interferon-alpha and capecitabine. After 2 courses of combination therapy with IFN-alpha and capecitabine, significant tumor responses were obtained; two out of four pulmonary metastatic sites disappeared completely, one site showed over 50% decrease in size, and the remaining one site did no change in size. The regimen was well tolerated and toxicity observed was World Health Organization grade 1 anorexia. His disease status was maintained as stable disease by the repeated treatment with interferon-alpha and capecitabine for 17 months after tumor responses were obtained. However, tumor progression was observed thereafter. He is at present under treatment with sorafenib. This is the first case report of metastatic renal cell carcinoma, which showed different responses to two types of 5-fluorouracil prodrugs in combination with interferon-alpha, suggesting the biochemical modulation of capecitabine by interferon-alpha as a possible mechanism underlying the antitumor effect of the combination of interferon-alpha and capecitabine at the clinical setting. Present case also suggests that a combination of tumor-selective capecitabine with interferon-alpha is a potentially useful therapeutic option in metastatic renal cell carcinoma.
Tumor-like pulmonary sarcoidosis diagnosed by CT-guided transthoracic lung biopsy
Authors: Sidiropoulou N , Filippousis P , Apostolopoulou S , Tsangaridou I , Thanos L 
Published: November 2009

Abstract

Introduction
Most patients referred for lung biopsy have a focal lesion that is likely to be a carcinoma and fine needle aspiration (FNA) is usually sufficient to confirm diagnosis. Percutaneous cutting needle biopsy (CNB) is an important and potential diagnostic technique when non carcinomatous disease is suspected or when the pulmonary disease is unclear, so tissue architecture is very important.

Case presentation
We present a case of a 24 year old male arrived at our hospital with dyspnea and unusual computed tomography (CT) findings of sarcoidosis. Chest X-ray and CT scan revealed multiple masses in both lungs suggesting lung metastasis. Bronchoscopy and bronchoalveolar lavage did not reveal any malignant cells. None of the laboratory examinations revealed any primary extrapulmonary tumor. The patient underwent CT-guided core needle biopsy. Histopathological examination confirmed the diagnosis of sarcoidosis.

Conclusion
CT-guided core needle biopsy is a very helpful diagnostic tool in order to determine the benign or malignant nature of a thoracic lesion.
Cement leakage in a symptomatic vertebral hemangioma: a case report and review of the literature
Authors: Evangelopoulos Dimitrios S , Kontovazenitis Panos , Kokkinis Konstantinos , Glynos Michalis , Korres Dimitrios S , Sapkas George 
Published: November 2009

Abstract
We present the case of a 50-year-old male with consistent back pain, not resolving with conservative treatment. Plain radiograms demonstrated a lytic lesion at the level of the 8th thoracic vertebra. Thorough examination with computerized tomography and magnetic resonance imaging revealed a hemangioma extending to the posterior third of the vertebral body, compressing the spinal cord at the level of 8th thoracic vertebra. A percutaneous vertebroplasty was performed. The post-operative computerized tomography scan demonstrated cement leakage. After thorough cement removal combined with extensive decompression and posterior stabilization, the patient reported gradual improvement of his symptoms and was able to return successfully to his work a few months later.
Choroidopathy and kidney disease: a case report and review of the literature
Authors: Kamdar Nirav V , Erko Amsalu , Ehrlich Jason S , Kim Jonathan W , Kambham Neeraja , Chertow Glenn M 
Published: November 2009

Abstract
The patient was a 41 year-old Mexican American women who presented with a decrease in visual acuity along with periorbital and peripheral edema. She was diagnosed with bilateral serous retinal detachment and diffuse proliferative lupus nephritis. She improved considerably in hospital after treatment with corticosteroids.
High-resolution computed tomography illustrating pulmonary lymphangitic carcinomatosis in a patient with advanced pancreatic cancer: a case report
Authors: Wan-Hsiu Liao , Sheng-Hsiang Lin , Tsu-Tuan Wu 
Published: November 2009

Abstract
We present a case of advanced pancreatic cancer with diffuse pulmonary interstitial infiltrates and dyspnea in a 61-year-old Asian Taiwanese female. Although surgical lung biopsy is the diagnostic gold standard in most interstitial lung disease, it frequently leads to complications in sick patients. Based on the overall clinico-radiologic correlation, a diagnosis of pulmonary lymphangitic carcinomatosis was supported by the characteristic findings in high-resolution computed tomography.
Sero-negative celiac disease with dermatitis herpetiformes: a case report
Authors: Adhi Mehreen , Farooq Asma , Hamid Syed Ali , Hasan Rabia , Mamji Salman , Baloch Akhtar Ali 
Published: November 2009

Abstract

Introduction
We report a case of sero-negative celiac disease in Pakistan.

Case presentation
A 20-year-old female presented with papulovesicular rash for 15 years, diarrhea for 8 years, spasms of hands and twitching of face for 4-5 months. She had mild anemia, low vitamin-D3 and serum calcium. On exclusion of other causes of malabsorption, anti-tissue transglutaminase antibodies (immunoglobulin-A & immunoglobulin-G), anti-endomysial antibodies, total immunoglobulin-A levels and skin biopsy were performed, which were normal. Intestinal biopsy revealed subtotal villous atrophy. Patient was prescribed gluten-free diet, to which she responded with alleviation of symptoms.

Conclusion
Negative serology should not rule out celiac disease; intestinal biopsy should be performed if there is strong clinical suspicion.
An unusual case of bilateral hydroureteronephrosis caused by uretero-vesico malakoplakia in a young male: a case report and review of the literature
Authors: Patnayak Rashmi , Reddy Mandyam Kumaraswamy , Subramanian Srinivasn , Jena Amitabh , Ravisankar Gangi , Dandu Rambabu Satya 
Published: November 2009

Abstract

Introduction
Malakoplakia is an unusual chronic inflammatory disease. Malakoplakia of the bladder and ureter is quite rare.

Case presentation
We present a case of a young male diagnosed as malakoplakia of urinary bladder and ureter. He presented with bilateral hydroureteronephrosis. The patient underwent left ureterocystotomy. Again, he was admitted after a gap of ten years and with features of end stage renal disease.

Conclusion
This rare case of urinary bladder and ureter malakoplakia in a young male is presented, to stress upon the fact that though it is a chronic inflammatory disease, yet its outcome over the years is dismal.
Prosthetic rehabilitation of hypophosphatasia: a case report
Authors: Bağiş Bora , Baltacioğlu Esra , Aydoğan Elif , Tamam Evşen 
Published: November 2009

Abstract
Hypophosphatasia is a congenital disease characterized by deficiency of serum and tissue non-specific alkaline phosphatase activity. The disease occurs due to mutations in the liver/bone/kidney alkaline phosphatase gene. Six clinical forms of hypophosphatasia are recognized. Systemic symptoms of the disease are respiratory complications, premature craniosynostosis, widespread demineralization and rachitic changes in the metaphases, stress fractures, chondrocalcinosis and osteoarthropathy. Characteristic dental symptoms are premature deciduous teeth loss, premature exfoliation of fully rooted primary teeth, severe dental caries and alveolar bone loss. This clinical report describes the prosthetic rehabilitation of a twenty two year-old Turkish female patient with hypophosphatasia.
Intramural duodenal hematoma and hemoperitoneum after endoscopic treatment in a patient with chronic renal failure on hemodialysis: a case report
Authors: Chung Sungjin , Park Cheol Whee , Chung Hyun Wha , Shin Seok Joon , Chang Yoon Sik 
Published: November 2009

Abstract

Introduction
An intramural duodenal hematoma is a rare but recognized complication that usually develops after abdominal trauma, predominantly in children and young adults.

Case Presentation
We report the case of a patient that developed an intramural duodenal hematoma after endoscopic treatment for a bleeding ulcer who also was undergoing conventional hemodialysis for chronic renal failure associated with lupus nephritis. A hemoperitoneum and near-total duodenal obstruction developed but spontaneously resolved with conservative treatment.

Conclusion
Clinicians should be aware of such possible complications after endoscopic hemostasis in patients with coagulation disorders.
Probiotics and gastrointestinal disease: successes, problems and future prospects
Authors: Culligan Eamonn P , Hill Colin , Sleator Roy D 
Published: November 2009

AbstractGastrointestinal disease is a major cause of morbidity and mortality worldwide each year. Treatment of chronic inflammatory gastrointestinal conditions such as ulcerative colitis and Crohn's disease is difficult due to the ambiguity surrounding their precise aetiology. Infectious gastrointestinal diseases, such as various types of diarrheal disease are also becoming increasingly difficult to treat due to the increasing dissemination of antibiotic resistance among microorganisms and the emergence of the so-called 'superbugs'. Taking into consideration these problems, the need for novel therapeutics is essential. Although described for over a century probiotics have only been extensively researched in recent years. Their use in the treatment and prevention of disease, particularly gastrointestinal disease, has yielded many successful results, some of which we outline in this review. Although promising, many probiotics are hindered by inherent physiological and technological weaknesses and often the most clinically promising strains are unusable. Consequently we discuss various strategies whereby probiotics may be engineered to create designer probiotics. Such innovative approaches include; a receptor mimicry strategy to create probiotics that target specific pathogens and toxins, a patho-biotechnology approach using pathogen-derived genes to create more robust probiotic stains with increased host and processing-associated stress tolerance profiles and meta-biotechnology, whereby, functional metagenomics may be used to identify novel genes from diverse and vastly unexplored environments, such as the human gut, for use in biotechnology and medicine.
Searching for SNPs with cloud computing
Authors: Langmead Ben , Schatz Michael C , Lin Jimmy , Pop Mihai , Salzberg Steven L 
Published: November 2009

AbstractAs DNA sequencing outpaces improvements in computer speed, there is a critical need to accelerate tasks like alignment and SNP calling. Crossbow is a cloud-computing software tool that combines the aligner Bowtie and the SNP caller SOAPsnp. Executing in parallel using Hadoop, Crossbow analyzes data comprising 38-fold coverage of the human genome in three hours using a 320-CPU cluster rented from a cloud computing service for about $85. Crossbow is available from http://bowtie-bio.sourceforge.net/crossbow/.
Phase I Study of Accelerated Conformal Radiotherapy for Stage I Non–Small-Cell Lung Cancer in Patients With Pulmonary Dysfunction: CALGB 39904
Authors: Bogart Jeffrey A. , Hodgson Lydia , Seagren Stephen L. , Blackstock A. William , Wang Xiaofei , Lenox Robert , Turrisi Andrew T. , Reilly John , Gajra Ajeet , Vokes Everett E. , Green Mark R. 
Published: November 2009

Purpose The optimal treatment for medically inoperable stage I non–small-cell lung cancer (NSCLC) has not been defined. Patients and Methods Cancer and Leukemia Group B trial 39904 prospectively assessed accelerated, once-daily, three-dimensional radiotherapy for early-stage NSCLC. The primary objectives were to define the maximally accelerated course of conformal radiotherapy and to describe the short-term and long-term toxicity of therapy. Entry was limited to patients with clinical stage T1N0 or T2N0 NSCLC (< 4 cm) and pulmonary dysfunction. The nominal total radiotherapy dose remained at 70 Gy, while the number of daily fractions in each successive cohort was reduced. Results Thirty-nine eligible patients were accrued (eight patients each on cohorts 1 to 4 and seven patients on cohort 5) between January 2001 and July 2005. One grade 3 nonhematologic toxicity was observed in both cohort 3 (dyspnea) and cohort 4 (pain). The major response rate was 77%. After a median follow-up time of 53 months, the actuarial median survival time of all eligible patients was 38.5 months. Local relapse was observed in three patients. Conclusion Accelerated conformal radiotherapy was well tolerated in a high-risk population with clinical stage I NSCLC. Outcomes are comparable to prospective reports of alternative therapies, including stereotactic body radiation therapy and limited resection, with less apparent severe toxicity. Further investigation of this approach is warranted.
Synthesis of Stereodefined 3-Alkylideneoxindoles by Palladium-catalyzed Reactions of 2-(Alkynyl)aryl Isocyanates with Thiols and Alcohols
Authors: Miura Tomoya , Toyoshima Takeharu , Ito Yoshiteru , Murakami Masahiro 
Published: November 2009

Abstract
The palladium-catalyzed reactions of 2-(alkynyl)aryl isocyanates with thiols and alcohols caused cyclization to give stereodefined 3-alkylideneoxindoles incorporating sulfanyl and alkoxy groups on the alkylidene unit, respectively.
Selective Production of Xylose and Xylo-oligosaccharides from Bamboo Biomass by Sulfonated Allophane Solid Acid Catalyst
Authors: Ogaki Yoshihiro , Shinozuka Yu , Hatakeyama Moriaki , Hara Takayoshi , Ichikuni Nobuyuki , Shimazu Shogo 
Published: November 2009

Abstract
Bamboo biomass was hydrolyzed by using sulfonated allophane catalyst and hemicellulose in bamboo was preferentially decomposed to xylose and xylo-oligosaccharides in the range from 130 to 160 °C.
Silyl Migration in Conjunction with Substitution on Silicon in Copper(I) t-Butoxide-promoted Coupling between o-Silylphenyl Ketones and Organic Halides
Authors: Tsubouchi Akira , Matsuda Hiroko , Kira Takashiro , Takeda Takeshi 
Published: November 2009

Abstract
(Z)-Di-t-butoxymethylsilyl enol ethers were stereoselectively produced by the copper(I) t-butoxide-promoted cross-coupling of o-(dimethylphenylsilyl)phenyl ketones with organic halides. The reaction proceeds via the formation of arylcopper species generated by silyl migration to enolate oxygen, accompanied by substitution of t-butoxy on silicon.
Elevated vitamin D receptor levels in genetic hypercalciuric stone-forming rats are associated with downregulation of Snail
Authors: Bai Shaochun , Wang Hongwei , Shen Jikun , Zhou Randal , Bushinsky David A , Favus Murray J 
Published: November 2009

Abstract
Patients with idiopathic hypercalciuria (IH) and genetic hypercalciuric stone-forming (GHS) rats, an animal model of IH, are both characterized by normal serum Ca, hypercalciuria, Ca nephrolithiasis, reduced renal Ca reabsorption, and increased bone resorption. Serum 1,25-dihydroxyvitamin D [1,25(OH)2D] levels are elevated or normal in IH and are normal in GHS rats. In GHS rats, vitamin D receptor (VDR) protein levels are elevated in intestinal, kidney, and bone cells, and in IH, peripheral blood monocyte VDR levels are high. The high VDR is thought to amplify the target-tissue actions of normal circulating 1,25(OH)2D levels to increase Ca transport. The aim of this study was to elucidate the molecular mechanisms whereby Snail may contribute to the high VDR levels in GHS rats. In the study, Snail gene expression and protein levels were lower in GHS rat tissues and inversely correlated with VDR gene expression and protein levels in intestine and kidney cells. In human kidney and colon cell lines, ChIP assays revealed endogenous Snail binding close to specific E-box sequences within the human VDR promoter region, whereas only one E-box specifically bound Snail in the rat promoter. Snail binding to rat VDR promoter E-box regions was reduced in GHS compared with normal control intestine and was accompanied by hyperacetylation of histone H3. These results provide evidence that elevated VDR in GHS rats likely occurs because of derepression resulting from reduced Snail binding to the VDR promoter and hyperacetylation of histone H3. © 2010 American Society for Bone and Mineral Research.
The shifting trajectory of growth in femur length during gestation
Authors: Bjørnerem Åshild , Johnsen Synnøve L , Nguyen Tuan V , Kiserud Torvid , Seeman Ego 
Published: November 2009

Abstract
Bone size is a determinant of bone strength and tracks in its percentile of origin during childhood and adolescence. We hypothesized that the ranking of an individual's femur length (FL) is established in early gestation and tracks thereafter. Fetal FL was measured serially using 2D ultrasound in 625 Norwegian fetuses. Tracking was assessed using Pearson correlation, a generalized estimating equation model, and by calculating the proportion of fetuses whose FL remained within the same quartile. Baseline FL Z-score (weeks 10 to 19) and later measurements correlated, but more weakly as gestation advanced: r = 0.59 (weeks 20 to 26); r = 0.45 (weeks 27 to 33); and r = 0.32 (weeks 34 to 39) (p &lt; 0.001). Tracking within the same quartile throughout gestation occurred in 13% of fetuses. Of the 87% deviating, 21% returned to the quartile of origin, so 34% began and ended in the same quartile, 38% deviated by one quartile, and 28% deviated by two or more quartiles by the end of gestation. A standard deviation higher baseline FL Z-score, placental weight (150 g), maternal height (5 cm), and weight (10 kg), was associated with a 0.25, 0.15, 0.10, and 0.05 SD higher FL Z-score at the end of gestation, respectively (p ranging from &lt;0.001 to 0.02). Tracking within the same percentile throughout the whole of gestation, as suggest by growth charts, is uncommon. Deviation from tracking is more common and is the result of changes in growth velocity within and between fetuses and is partly influenced by maternal, fetal, and placental factors. © 2010 American Society for Bone and Mineral Research
Rosiglitazone therapy is associated with major clinical improvements in a patient with fibrodysplasia ossificans progressiva
Authors: Gatti Davide , Viapiana Ombretta , Rossini Maurizio , Silvano Adami 
Published: November 2009

Abstract
Fibrodysplasia ossificans progressiva (FOP) is a rare genetic condition characterized by progressive heterotopic ossification, increasing disability, and cumulative immobility. Thiazolidinediones, introduced in 1999 for the treatment of diabetes, enhance bone marrow adipogenesis at the expense of new bone formation, and this might be exploited for the treatment of FOP. A 48-year-old woman with severe FOP characterized by continuous flares that she was partially controlling only with high prednisone doses was given rosiglitazone (initially 4 mg and then 8 mg daily) for 14 months. No new flare-ups were observed during rosiglitazone therapy as compared to the five episodes observed during the previous year while on 20 to 25 mg prednisone daily. The steroid dose could be lowered progressively to 5 mg/day, the skin became softer, and the articular mobility improved impressively. This case report seems to suggest that rosiglitazone therapy, possibly in association with small doses of prednisone, is associated with important clinical improvements in patients with FOP. © 2010 American Society for Bone and Mineral Research
Filamin A regulates monocyte migration through Rho small GTPases during osteoclastogenesis
Authors: Leung Roland , Wang Yongqiang , Cuddy Karl , Sun Chunxiang , Magalhaes Joyce , Grynpas Marc , Glogauer Michael 
Published: November 2009

Abstract
Osteoclastogenesis (OCG) results from the fusion of monocytes after stimulation with macrophage colony-stimulating factor (M-CSF) and receptor activator of NF-κB ligand (RANKL). Migration of monocytes into close proximity precedes critical fusion events that are required for osteoclast formation. Cellular migration requires leading-edge actin cytoskeleton assembly that drives cellular locomotion. Filamin A (FLNa) cross-links F-actin filaments in the leading edge of migrating cells and also has been shown to regulate signal transduction during cell migration. However, little is known about the possible role of FLNa in osteoclastogenesis. Our objective in this study was to investigate the role of FLNa in osteoclastogenesis. Bone marrow monocytes isolated from the tibiae and femora of wild type (WT) and Flna-null mice were cultured for 6 days with M-CSF and RANKL, and osteoclasts were identified by tartrate-resistant acid phosphatase (TRACP) staining. The Flna-null mouse skeletal phenotype was characterized using dual-energy X-ray absorptiometry (DXA) to analyze the skeleton, as well as tests on blood chemistry. Osteoclast levels in vivo were quantified by counting of TRACP-stained histologic sections of distal femora. To elucidate the mechanisms by which Flna regulates osteoclastogenesis, migration, actin polymerization, and activation of Rho GTPases, Rac1, Cdc42, and RhoA were assessed in monocytes during in vitro OCG. Deficiencies in migration were rescued using constitutively active Rac1 and Cdc42 TAT fusion proteins. The RANKL signaling pathway was evaluated for activation by monitoring nuclear translocation of NFκB and c-jun and expression of key osteoclast genes using quantitative real-time polymerase chain reaction (qRT-PCR). Our results show that Flna-null monocytes formed fewer osteoclasts in vitro, and those that were formed were smaller with fewer nuclei. Decreased OCG was reflected in vivo in TRACP-stained histologic bone sections. Flna-null monocytes experienced impaired migratory ability. When OCG was performed at increasing starting cellular plating densities in order to decrease intercellular distances, there was progressive rescue of Flna-null osteoclast formation comparable with WT levels, confirming that Flna regulates monocyte migration prefusion. Activation of the actin cytoskeleton regulators Rac1, Cdc42, and RhoA and actin free-barbed end generation were partially or completely abrogated in Flna-null monocytes; however, monocyte migration was restored on rescuing with constitutively active Rac1 and Cdc42 TAT fusion proteins. We conclude that filamin A is required for osteoclastogenesis by regulating actin dynamics via Rho GTPases that control monocyte migration. © 2010 American Society for Bone and Mineral Research