bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dehydration‐Induced Cluster Consolidation in a Metal‐Organic Framework for Sieving Hexane Isomers
Authors: Jiang Zhi‐Jie , Wang Ying , Luo Dong , Wei Rong‐Jia , Lu Weigang , Li Dan 
Published: April 2024

AbstractMetal‐organic frameworks (MOFs) that exhibit dynamic phase‐transition behavior under external stimuli could have great potential in adsorptive separations. Here we report on a zinc‐based microporous MOF (JNU‐80) and its reversible transformation between two crystalline phases: large pore (JNU‐80‐LP) and narrow pore (JNU‐80‐NP). Specifically, JNU‐80‐LP can undergo a dehydration‐induced cluster consolidation under heat treatment, resulting in JNU‐80‐NP with a reduced channel that allows exclusion of di‐branched hexane isomers while high adsorption of linear and mono‐branched hexane isomers. We further demonstrate the fabrication of MOF‐polymer composite (JNU‐80‐NP‐block) and its application in the purification of di‐branched isomers from liquid‐phase hexane mixtures (98 % di‐branched) at room temperature, affording the di‐branched hexane isomers with 99.5 % purity and close to 90 % recovery rate over ten cycles. This work illustrates an interesting dehydration‐induced cluster consolidation in MOF structure and the ensuing channel shrinkage for sieving di‐branched hexane isomers, which may have important implications for the development of MOFs with dynamic behavior and their potential applications in non‐thermal driven separation technologies.
Lithium Pre‐Storage Enables High Initial Coulombic Efficiency and Stable Lithium‐Enriched Silicon/Graphite Anode
Authors: Gao Ying‐Jie , Cui Cheng‐Hao , Huang Zhi‐Kun , Pan Guo‐Yu , Gu Yuan‐Fan , Yang Ya‐Nan , Bai Fan , Sun Zhuang , Zhang Tao 
Published: April 2024

AbstractApplication of silicon‐based anodes is significantly challenged by low initial Coulombic efficiency (ICE) and poor cyclability. Traditional pre‐lithiation reagents often pose safety concerns due to their unstable chemical nature. Achieving a balance between water‐stability and high ICE in prelithiated silicon is a critical issue. Here, we present a lithium‐enriched silicon/graphite material with an ultra‐high ICE of ≥110 % through a high‐stable lithium pre‐storage methodology. Lithium pre‐storage prepared a nano‐drilled graphite material with surficial lithium functional groups, which can form chemical bonds with adjacent silicon during high‐temperature sintering. This results in an unexpected O−Li−Si interaction, leading to in situ pre‐lithiation of silicon nanoparticles and providing high stability in air and water. Additionally, the lithium‐enriched silicon/graphite materials impart a combination of high ICE, high specific capacity (620 mAh g−1), and long cycling stability (>400 cycles). This study opens up a promising avenue for highly air‐ and water‐stable silicon anode prelithiation methods.
Boron‐Catalyzed C1 Copolymerization of Arsonium and Sulfoxonium Ylides toward Unrepresented Structures and Fluorescence Properties
Authors: Zhou Mingtao , Hadjichristidis Nikos 
Published: April 2024

AbstractThe first synthesis of well‐defined poly(methylene‐co‐1,1‐diphenylpropenenylene) (C1‐co‐C1’), equivalent to poly(ethylene‐co‐diphenylbutadiene) copolymers was accomplished by C1 copolymerization of novel diphenylpropenyl triphenyl arsonium ylides (Ph2AY) and dimethylsulfoxonium methylide (Me2SY) using B‐thexylborepane as initiator. All polymerization conditions, including feed ratio, temperature, and reaction time, were optimized. A series of photoluminescent poly(ethylene‐co‐diphenylbutadiene)s were synthesized at different feed ratios, opening a new synthetic horizon for poly(ethylene‐co‐disubstitutedbutadiene) copolymers. Notably, a new C1 segment, arising from a double bond rearrangement, was confirmed by NMR, resulting in an unprecedented two‐monomer three‐structure random terpolymer. An unexpected red‐shift phenomenon in the fluorescence spectra was observed with increasing the ratio of Ph2AY in the copolymer. This shift is attributed to the aggregation of diphenylbutadiene segment, similar to through‐space conjugation (TSC), likely induced by a decrease in the crystallinity of copolymers. Furthermore, another disubstituted allylic triphenyl arsonium ylides, (E)‐2‐phenylbutenyl triphenyl arsonium ylide (MePhAY) was also synthesized and investigated. These additional compounds expand the knowledge and the potential applications of such copolymerization techniques in advanced materials.
Enhancing Ion Adsorption Capability through the Strong Interaction in Co9S8‐Carbon Hybrids Achieves Superior Sodium Ion Storage
Authors: Ma Xinyi , He Xiaoyue , Yu Lai , Ahmad Nazir , Tao Zongzhi , Jiang Zi Xuan , Liang Jia Cheng , Zeng Suyuan , Shi Liang , Zhang Genqiang 
Published: April 2024

AbstractMetal sulfides materials are promising anode candidates for Na+ storage due to their low cost and high theoretical capacity, while the complex phase transition and inevitable volume expansion during cycling restrain their practical applications. Herein, a simple one‐pot manipulation strategy was designed to construct Co9S8 nanoparticles strongly encapsulated in carbon nanotubes (Co9S8@C/NTs) composite structure with enhanced structural stability and reaction kinetics, resulting in greatly improved Na+ storage performance. Specifically, the obtained Co9S8@C/NTs could exhibit a remarkable capacity of 500 mAh g−1 at 0.5 A g−1 after 100 cycles and exceptional cycling stability over 600 cycles with 88 % capacity retention at 1 A g−1. Furthermore, the theoretical calculations combined with systematic characterizations confirm that the strong interaction between Co9S8 and the carbon matrix could greatly enhance the Na+ adsorption ability and facilitate the electron transfer dynamics for superior Na+ storage capability. More importantly, the full cell device can deliver an outstanding energy density of 144.32 Wh kg−1 and a decent cycling life with 82 % capacity retention of almost 100 cycles at 0.1 A g−1. This work could provide more valuable insights for designing advanced metal sulfide nanocomposites and demonstrate fascinating prospects for commercial application.
The normative values of pain thresholds in healthy Taiwanese
Authors: Pan Li‐Ling Hope , Ling Yu‐Hsiang , Lai Kuan‐Lin , Wang Yen‐Feng , Hsiao Fu‐Jung , Chen Shih‐Pin , Liu Hung‐Yu , Chen Wei‐Ta , Wang Shuu‐Jiun 
Published: April 2024

AbstractObjectiveQuantitative sensory testing is widely used in clinical and research settings to assess the sensory functions of healthy subjects and patients. It is of importance to establish normative values in a healthy population to provide reference for studies involving patients. Given the absence of normative values for pain thresholds in Taiwan, the aim of this study was to report the normative values for future reference in the Taiwanese population and compare the differences between male and female participants.MethodsHealthy adults without any chronic or acute pain condition were recruited. The pain thresholds were assessed over the cephalic (supraorbital area and masseter muscle) and extracephalic (medio‐volar forearm and thenar eminence) areas. The heat, cold, mechanical punctate, and pressure pain thresholds were measured with a standardized protocol. Comparisons between male and female participants were performed.ResultsOne hundred and thirty healthy participants (55 males: 30.4 ± 7.4 years; 75 females: 30.5 ± 8.1 years) finished the assessments. Male participants were less sensitive to mechanical stimuli, including pressure over masseter muscle (male vs. female: 178.5 ± 56.7 vs. 156.6 ± 58.4 kPa, p = .034) and punctate over medio‐volar forearm (male vs. female: 116.4 ± 45.2 vs. 98.7 ± 65.4 g, p = .011), compared to female participants. However, female participants were less sensitive to cold stimuli, indicated by lower cold pain thresholds over the supraorbital area (male vs. female: 18.6 ± 8.4 vs. 13.6 ± 9.3°C, p = .004), compared to male participants. No significant differences were found between sexes in other pain threshold parameters.ConclusionsWe provided the normative values of healthy male and female adults in Taiwan. This information is crucial for comparison in future pain‐related studies to identify potential hypoalgesia or hyperalgesia of tested subjects.
5Z‐7‐Oxozaenol attenuates cuprizone‐induced demyelination in mice through microglia polarization regulation
Authors: Chen Shiyu , Liu Siyao , Huang Yalun , Huang Shiwen , Zhang Wanzhou , Xie Huifang , Lu Lingli 
Published: April 2024

AbstractIntroductionDemyelination is a key factor in axonal degeneration and neural loss, leading to disability in multiple sclerosis (MS) patients. Transforming growth factor beta activated kinase 1 (TAK1) is a critical molecule involved in immune and inflammatory signaling pathways. Knockout of microglia TAK1 can inhibit autoimmune inflammation of the brain and spinal cord and improve the outcome of MS. However, it is unclear whether inhibiting TAK1 can alleviate demyelination.MethodsEight‐week‐old male c57bl/6j mice were randomly divided into five groups: (a) the control group, (b) the group treated with cuprizone (CPZ) only, (c) the group treated with 5Z‐7‐Oxozaenol (OZ) only, and (d) the group treated with both cuprizone and 15 μg/30 μg OZ. Demyelination in the mice of this study was induced by administration of CPZ (ig) at a daily dose of 400 mg/kg for consecutive 5 weeks. OZ was intraperitoneally administered at mentioned doses twice a week, starting from week 3 after beginning cuprizone treatment. Histology, rotarod test, grasping test, pole test, Western blot, RT‐PCR, and ELISA were used to evaluate corpus callosum demyelination, behavioral impairment, oligodendrocyte differentiation, TAK1 signaling pathway expression, microglia, and related cytokines.ResultsOur results demonstrated that OZ protected against myelin loss and behavior impairment caused by CPZ. Additionally, OZ rescued the loss of oligodendrocytes in CPZ‐induced mice. OZ inhibited the activation of JNK, p65, and p38 pathways, transformed M1 polarized microglia into M2 phenotype, and increased brain‐derived neurotrophic factor (BDNF) expression to attenuate demyelination in CPZ‐treated mice. Furthermore, OZ reduced the expression of proinflammatory cytokines and increases anti‐inflammatory cytokines in CPZ‐treated mice.ConclusionThese findings suggest that inhibiting TAK1 may be an effective approach for treating demyelinating diseases.
Pharmaceutical proteins at the interfaces and the role of albumin
Authors: Velankar Ketki Y. , Gawalt Ellen S. , Wen Yi , Meng Wilson S. 
Published: April 2024

AbstractA critical measure of the quality of pharmaceutical proteins is the preservation of native conformations of the active pharmaceutical ingredients. Denaturation of the active proteins in any step before administration into patients could lead to loss of potency and/or aggregation, which is associated with an increased risk of immunogenicity of the products. Interfacial stress enhances protein instability as their adsorption to the air‐liquid and liquid–solid interfaces are implicated in the formation of denatured proteins and aggregates. While excipients in protein formulations have been employed to reduce the risk of aggregation, the roles of albumin as a stabilizer have not been reviewed from practical and theoretical standpoints. The amphiphilic nature of albumin makes it accumulate at the interfaces. In this review, we aim to bridge the knowledge gap between interfacial instability and the influence of albumin as a surface‐active excipient in the context of reducing the immunogenicity risk of protein formulations.
Review of patient‐reported outcomes (PROs) and non‐PROs in randomized controlled trials addressing head/neck cancers
Authors: Gode Michelle , Faggion Clovis Mariano 
Published: April 2024

AbstractBackgroundTo assess the frequency of patient‐reported outcomes (PROs) and non‐PROs in randomized controlled trials (RCTs) addressing head/neck cancers.MethodsWe included RCTs about interventions to treat head/neck cancers. PubMed was searched on September 16, 2022 and included studies published during three periods (2000–2002, 2010–2012, and 2020–2022). Data on types of outcomes and instruments to measure them were extracted and organized into PROs and non‐PROs, and temporal trends for reporting outcomes were determined.ResultsThere was a reduction in the frequency of non‐PROs (40% to 22%) and an increase in PROs (5% to 19%) over 20 years. The frequency of reporting both non‐PROs and PROs seemed to be stable over the same period (55% to 58%). A great variety of instruments to measure PROs and non‐PROs was identified.ConclusionsThere has been a growth in the types of PROs in more recent years, and they were more frequently reported in RCTs. However, head/neck cancer trials with a combination of PROs and non‐PROs were the most prevalent.
Soft and hard tissue evaluation of guided socket shield implant cases
Authors: Trejo Pedro M. , Rivas Raysa , Trejo Corletta C. , Min Seiko , Nishikawa Arisa 
Published: April 2024

AbstractBackgroundThe socket‐shield (SS) technique results in long‐term functional osseo‐ and dento‐integration, preserving the dimensional stability of hard and soft tissues over time. This study aimed to describe the successful implementation of a surgical technique to facilitate “SS” cases.MethodsThe cases included males and females aged 32–81 years consecutively treated between 2020 and 2023 (longest follow‐up, 3.5 years). For each case, pre‐ and post‐operative cone‐beam computed tomography (Digital Imaging and Communications in Medicine files) and intraoral optical scans (IOS; STL files) were performed. Digital immediate implant placement and simultaneous tooth extraction and SS production were planned using an implant planning software. Implants were planned considering sagittal‐ridge and tooth‐root angular‐configuration. Surgical guides were used to perform the digitally‐supported SS technique. All cases were planned and surgically performed by one operator (Pedro M. Trejo). Preoperative digital IOS‐models were superimposed to post‐operative models to assess soft‐tissue changes. Pre and post sagittal views were used to assess the radiographic buccal‐plate thickness at various healing times. An investigator not involved with case planning or treatment performed measurements.ResultsResults reflected soft‐tissue stability with minimal mean thickness change at 0‐, 1‐, 2‐, and 3‐mm measurement levels of 0.03, ‐0.2, 0.14, ‐0.07, and 0.04 mm, respectively, with a mean gingival‐margin change of 0.04 mm. The free gingival‐margin change ranged from a 0.58‐mm gain in height to a ‐0.57‐mm loss. The mean radiographic buccal‐plate thickness post‐operatively was 2.04 mm (range, 0.7–2.9 mm).ConclusionThe digitally‐supported guided SS technique enables predictable immediate implant‐placement positions and stable buccal peri‐implant soft and hard tissues over time.Key PointsWhy are these cases new information?

The uniqueness of the surgical technique described herein is that it results in favorable positions of immediate, socket‐shielded (SSed), implant placements, with soft‐ and hard‐tissue stability as the byproduct.
What are the keys to successful management of these cases?

Digitally, plan for the best possible implant position within the alveolar housing to satisfy prosthetic requirements, and then adjust this position to accommodate the socket shield dimensions.
Digitally, provide a space/gap between the future dentinal shield and the implant.
Clinically, allow for time to carve the final position and dimensions of the shield. Plan ahead the extent of the apical third of the SS, and the removal of the apex, if dealing with a long root.
What are the primary limitations to success in these cases?

Inadequate use of digital technology; case‐sensitive technique requires proper execution of each digital and technical clinical step.
Enterolyin S, a Polythiazole‐containing Hemolytic Peptide from Enterococcus caccae
Authors: Shi Chengyou , Patel Varshal A. , Mitchell Douglas A. , Zhao Huimin 
Published: April 2024

AbstractThe β‐hemolytic factor streptolysin S (SLS) is an important linear azol(in)e‐containing peptide (LAP) that contributes significantly to the virulence of Streptococcus pyogenes. Despite its discovery 85 years ago, SLS has evaded structural characterizing owing to its notoriously problematic physicochemical properties. Here, we report the discovery and characterization of a structurally analogous hemolytic peptide from Enterococcus caccae, termed enterolysin S (ELS). Through heterologous expression, site‐directed mutagenesis, chemoselective modification, and high‐resolution mass spectrometry, we found that ELS contains an intriguing contiguous octathiazole moiety. The discovery of ELS expands our knowledge of hemolytic LAPs by adding a new member to this virulence‐promoting family of modified peptides.
In Situ Formation of Suspended Graphene Windows for Lab‐Based XPS in Liquid and Gas Environments
Authors: Jones Elizabeth S. , Drivas Charalampos , Gibson Joshua S. , Swallow Jack E. N. , Jones Leanne A. H. , Bricknell Thomas D. J. , van Spronsen Matthijs A. , Held Georg , Isaacs Mark A. , Parlett Christopher M. A. , Weatherup Robert S. 
Published: April 2024

AbstractEnvironmental cells sealed with photoelectron‐transparent graphene windows are promising for extending X‐ray photoelectron spectroscopy (XPS) to liquid and high‐pressure gas environments for in situ and operando studies. However, the reliable production of graphene windows that are sufficiently leak‐tight for extended measurements remains a challenge. Here we demonstrate a PDMS/Au(100 nm)‐supported transfer method that reliably produces suspended graphene on perforated silicon nitride membranes without significant contamination. A yield of ~95 % is achieved based on single‐layer graphene covering >98 % of the holes in the silicon nitride membrane. Even higher coverages are achieved for stacked bilayer graphene, allowing wet etching (aqueous KI/I2) of the Au support to be observed in a conventional lab‐based XPS system, thereby demonstrating the in situ formation of leak‐tight, suspended graphene windows. Furthermore, these windows allow gas‐phase measurements at close to atmospheric pressure, showing future promise for XPS under higher‐pressure gas environments in conventional lab‐based systems.
Efficient Alkaline Water Oxidation Electrocatalysis Enabled via the Modulation of Sn‐Containing Anions towards NiFe Oxyhydroxide
Authors: Xu Jiaxin , Yang Ruotao , Hou Tianjue , Chen Jinxin , Yang Hongyuan , Menezes Prashanth W. , Chen Ziliang 
Published: April 2024

AbstractDespite being considered as efficient non‐noble metal‐based electrocatalysts for alkaline oxygen evolution reaction (OER), NiFe (oxy)hydroxides (NiFeOxHy) typically fall short of meeting practical requirements. To address this challenge, herein, we introduce a facile in situ electrochemical incorporation technique to form Sn‐doped NiFe‐layered double hydroxide (NiFeSn‐LDH) precatalysts. Subsequently, under the alkaline OER process, the precatalyst evolves into stannate ion‐adsorbed NiFe oxyhydroxides (NiFeOOH). The presence of these stable stannate oxyanions plays a key role in mitigating Fe leaching, optimizing the electronic structure of NiFeOOH, and improving its reaction kinetics, thereby significantly enhancing alkaline OER performance. Notably, the nickel foam‐supported NiFeSn‐LDH demonstrates impressive results delivering a large current density of 100 mA cm−2 at an overpotential as low as ~260 mV and maintaining the industrial‐relevant ~500 mA cm−2 current density over 5 days with negligible activity decay, surpassing the performances of most of the transition metal‐based electrocatalysts. Comprehensive advanced characterizations of the precatalysts, before and after the OER reactions, have been performed to uncover stable residual stannate ions at the surface of NiFeOxHy and to determine their pivotal role in promoting alkaline OER.
Application of time‐space neighborhood standardization technology to complex multi‐stage process fault detection
Authors: Feng Liwei , Guo Shaofeng , Wu Yifei , Xing Yu , Li Yuan 
Published: April 2024

AbstractTo solve the problem that the multi‐stage process with dynamicity and nonlinear is hard to monitor effectively, the time‐space neighborhood standardization (TSNS) method is proposed, which is further applied to partial least squares (PLS) to propose TSNS and PLS (TSNS‐PLS) method for process fault detection. TSNS can transform multi‐stage data into single‐stage data that approximately obeys a standard normal distribution, remove temporal correlation between samples at previous and subsequent moments in the process data, and separate online fault samples. TSNS makes the transformed process data satisfy the requirements of the PLS method for process data and can significantly improve the fault detection rate of the PLS method. Finally, the performance of TSNS‐PLS was examined by a numerical simulation process and the penicillin fermentation process design fault detection experiment.
A Case‐Study on the Photophysics of Chalcogen‐Substituted Zinc(II) Phthalocyanines
Authors: Ezquerra Riega Sergio D. , Gutierrez Suburu Matías E. , Rodríguez Hernán B. , Lantaño Beatriz , Kleinschmidt Martin , Marian Christel M. , Strassert Cristian A. 
Published: April 2024

AbstractSinglet dioxygen has been widely applied in different disciplines such as medicine (photodynamic therapy or blood sterilization), remediation (wastewater treatment) or industrial processes (fine chemicals synthesis). Particularly, it can be conveniently generated by energy transfer between a photosensitizer's triplet state and triplet dioxygen upon irradiation with visible light. Among the best photosensitizers, substituted zinc(II) phthalocyanines are prominent due to their excellent photophysical properties, which can be tuned by structural modifications, such as halogen‐ and chalcogen‐atom substitution. These patterns allow for the enhancement of spin‐orbit coupling, commonly attributed to the heavy atom effect, which correlates with the atomic number (
) and the spin‐orbit coupling constant (
) of the introduced heteroatom. Herein, a fully systematic analysis of the effect exerted by chalcogen atoms on the photophysical characteristics (absorption and fluorescence properties, lifetimes and singlet dioxygen photogeneration), involving 30 custom‐made β‐tetrasubstituted chalcogen‐bearing zinc(II) phthalocyanines is described and evaluated regarding the heavy atom effect. Besides, the intersystem crossing rate constants are estimated by several independent methods and a quantitative profile of the heavy atom is provided by using linear correlations between relative intersystem crossing rates and relative atomic numbers. Good linear trends for both intersystem crossing rates (S1‐T1 and T1‐S0) were obtained, with a dependency on the atomic number and the spin‐orbit coupling constant scaling as
and
, respectively The trend shows to be independent of the solvent and temperature.
TEMPO/O2 Synergistically Mediated BiBrO‐Photocatalyzed Decarboxylative Phosphorylation of N‐Arylglycines
Authors: Ouyang Wen‐Tao , Ji Hong‐Tao , Liu Yuan‐Yuan , Li Ting , Jiang Yan‐Fang , Lu Yu‐Han , Jiang Jun , He Wei‐Min 
Published: April 2024

AbstractWith both TEMPO and O2 (in air) as the homogeneous redox mediators, BiBrO as the heterogeneous semiconductor photocatalyst, the first example of semi‐heterogeneous photocatalytic decarboxylative phosphorylation of N‐arylglycines with diarylphosphine oxides was established. A series of α‐amino phosphinoxides were efficiently synthesized.