bluuebunny/crossref_metadata_2025_split huggingface dataset:
Synthesis and Catalytic Properties in Olefin Epoxidation of Octahedral Dichloridodioxidomolybdenum(VI) Complexes Bearing N,N‐Dialkylamide Ligands: Crystal Structure of [Mo2O4(μ2‐O)Cl2(dmf)4]
Authors: Gago Sandra , Neves Patrícia , Monteiro Bernardo , Pessêgo Márcia , Lopes André D. , Valente Anabela A. , Almeida Paz Filipe A. , Pillinger Martyn , Moreira José , Silva Carlos M. , Gonçalves Isabel S. 
Published: September 2009

AbstractThe catalytic performance of the complexes [MoO2Cl2(L)2] [L = N,N‐dimethylformamide (dmf), N,N‐dimethylacetamide (dma), N,N‐dimethylpropionamide (dmpa), N,N‐diethylformamide (def) and N,N‐diphenylformamide (dpf)] was examined in the epoxidation of cis‐cyclooctene with tert‐butyl hydroperoxide (tbhp) at 55 °C and in the absence of a cosolvent. The complexes showed high turnover frequencies in the range of 561–577 mol molMo–1 h–1, giving the epoxide as the only product in ≥98 % yield after 6 h. The reaction rates decreased significantly in consecutive runs carried out by recharging the reactors with olefin and oxidant. On the basis of the IR spectroscopic characterisation of the solids recovered at the end of the catalytic reactions, the decrease in activity is attributed to the formation of dioxido(μ‐oxido)molybdenum(VI) dimers. Accordingly, the treatment of [MoO2Cl2(dmf)2] with an excess amount of tbhp led to the isolation of [Mo2O4(μ2‐O)Cl2(dmf)4], which was characterised by single‐crystal X‐ray diffraction and found to exhibit a catalytic performance very similar to that found in the second runs for the mononuclear complexes. The kinetics of the reaction of [MoO2Cl2(dmf)2] with tbhp was further examined by UV/Vis spectroscopy, allowing rate constants and activation parameters to be determined. For the dpf adduct, the effect of different solvents on cyclooctene epoxidation and the epoxidation of other olefins, namely, (R)‐(+)‐limonene, α‐pinene and norbornene, were investigated. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2009)
Design, Self‐Assembly, and Molecular Structures of 3D Copper(II) Capsules Templated by BF4– Guest Anions
Authors: Desmarets Christophe , Policar Clotilde , Chamoreau Lise‐Marie , Amouri Hani 
Published: September 2009

AbstractThe synthesis of two 3D M2L4 copper(II) capsules, {[BF4⊂(CH3CN)2Cu2(L1)4][BF4]3} (1) and {[BF4⊂(BF4)2Cu2(L1)4][BF4]} (2), by using 1,3‐(benzimidazol‐1‐ylmethyl)‐2,5‐dimethoxy‐4,6‐dimethylbenzene (L1) as a semirigid exobidentate ligand and [Cu(CH3CN)4][BF4]2 as a metallobrick is reported. Single‐crystal X‐ray diffraction studies show the encapsulation of a BF4– anion in 1 and 2. Moreover, 2 displayed three coordinated BF4– anions, which is rare in supramolecular coordination host–guest chemistry. Remarkably, in both metallocages the weakly coordinated BF4– anion acts as a template and interacts with the metal center through a weak Cu···F contact. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2009)
Unique Catalytic Performance of the Polyoxometalate [Ti2(OH)2As2W19O67(H2O)]8–: The Role of 5‐Coordinated Titanium in H2O2 Activation
Authors: Kholdeeva Oxana A. , Donoeva Baira G. , Trubitsina Tatiana A. , Al‐Kadamany Ghada , Kortz Ulrich 
Published: September 2009

AbstractTetra‐n‐butylammonium (TBA) salts of the dititanium sandwich‐type 19‐tungstodiarsenate(III) [Ti2(OH)2As2W19O67(H2O)]8– (1) revealed a unique catalytic performance in the selective oxidation of organic compounds with aqueous hydrogen peroxide. The selectivity of alkene oxidation strongly depends on the amount of acidic protons in the cationic part of 1, which can be controlled by pH of precipitation of the TBA salt. Selectivities of almost 100 % were achieved for cyclohexene epoxidation by using TBA5.5Na1.5K0.5H0.5‐1. In the presence of TBA5.5K0.5H2‐1, cyclohexene epoxide readily transformed into trans‐1,2‐cyclohexanediol, 2‐hydroxycyclohexanone, and C–C bond‐cleavage products. No allylic oxidation products were found. Vicinal diols yielded α‐hydroxyketones and (di)carboxylic acids. Ketonization of cyclohexanol proceeded with selectivity as high as 98 %, whereas 1‐hexanol produced hexanal and hexanoic acid. The oxidation products are consistent with a heterolytic mechanism of H2O2 activation. The stability of 1 under turnover conditions was confirmed by IR spectroscopy. The presence of titanium atoms in the belt of 1 is vital for the catalytic performance. The titanium‐free analogue, [As2W21O67(H2O)]6– (2), revealed lower activity and selectivity in the oxidation of alcohols and was not active in the oxidation of alkenes. The catalytic performance of 1 contrasts that of polyoxometalates containing hexacoordinate Ti atoms, for example, TBA7[(PTiW11O39)2OH], TBA8H7[{Ti3PW9O37(OH)}3(PO4)], and TBA17[(α‐Ti3SiW9O37OH)3{TiO3(OH2)3}], for which a homolytic oxidation mechanism was manifested by the formation of cyclohexene allylic oxidation products. The unique ability of 1 to catalyze heterolytic oxidations with the use of hydrogen peroxide most likely originates from the specific coordination number (5) and geometry (square‐pyramidal) of the Ti atoms in this polyanion.(© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2009)
BiVO4 Hollow Nanospheres: Anchoring Synthesis, Growth Mechanism, and Their Application in Photocatalysis
Authors: Yin Wenzong , Wang Wenzhong , Shang Meng , Zhou Lin , Sun Songmei , Wang Lu 
Published: September 2009

AbstractAn anchoring method was developed to synthesize monoclinic BiVO4 (m‐BiVO4) hollow spheres with a size of about 700 nm by employing colloidal carbon spheres (CCSs) as hard templates. The influence of synthesis conditions and the growth mechanism were investigated with XRD, TEM, and SEM through a series of comparison experiments. It was found that two‐stage heat treatment was essential for the synthesis of BiVO4 hollow nanospheres. The Bi3+ ions were firstly adsorbed on the surface of the CCSs and worked as anchors in the first stage (80 °C). In the second stage (100 °C), the VO3– ions reacted with the anchored Bi3+ ions, and amorphous BiVO4 nanoparticles were thus precipitated on the CCSs surface. The analysis on the calcination process revealed that calcination promoted the crystallization of amorphous BiVO4 into m‐BiVO4 crystals at 236 °C and removed the CCSs at 353 °C. The as‐prepared BiVO4 hollow nanospheres exhibited higher photocatalytic activity than BiVO4 prepared by the aqueous method and by a solid‐state reaction in the degradation of rhodamine B and acetaldehyde, which could be attributed to their higher BET surface area (5.85 m2 g–1) and larger band gap (2.36 eV). Given the general adsorption of metal ions on the CCSs surface, this anchoring method could be extended to synthesize other hollow‐structured multicomponent oxides. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2009)
Homo‐ and Copolymerization of Aromatic Diynes by Ruthenium/Acid‐Promoted (RAP) Catalysis
Authors: Pasquini Chiara , Fratoddi Ilaria , Bassetti Mauro 
Published: September 2009

Abstract9,9‐Bis(2′‐ethylhexyl)‐2,7‐diethynylfluorene (1) or 1‐(2′‐ethylhexyloxy)‐2,5‐diethynyl‐4‐methoxybenzene (2) react in the presence of the [{RuCl(μ‐Cl)(p‐cymene)}]2/AcOH catalytic system to yield the corresponding poly(aryleneethynylenevinylene) π‐conjugated homopolymers, featuring the areneenyne repeat unit (Ar–C≡C–CH=CH–) and characterized by high regio‐ and stereoselectivity [(E) > 93 %]. The copolymerization of 1 and 2 affords poly‐(E)‐FL‐ethynylenevinylene‐co‐(E)‐MEH‐ethynylenevinylene [FL = fluorene; MEH = 1‐(2′‐ethylhexyloxy)‐4‐methoxybenzene], as the first example of a random copolymer derived from the polyaddition process of aromatic diynes. The catalytic system of this atom‐economic polyaddition process is formed in situ from the commercially available ruthenium dimer and acetic acid and promotes the C–C coupling at room temperature. The branched 2‐ethylhexyl chains in the arene moiety assist the formation of polymers with degrees of polymerization in the range of 9–20 repeat units. The optical properties of the new polymers were studied in chloroform solution and in film and compared to those of the main classes poly(arylenevinylene) and poly(aryleneethynylene) conjugated polymers.(© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2009)
Synthesis of the First Selenium‐Containing Acyclic Nucleosides and Anomeric Spironucleosides from Carbohydrate Precursors
Authors: Maza Susana , López Óscar , Martos Sergio , Maya Inés , Fernández‐Bolaños José G. 
Published: September 2009

AbstractWe report the synthesis of acyclic and spiranic imidazole‐derived C‐selenonucleosides. 5‐Hydroxy‐4‐tetrahydroxybutyl imidazolidine‐2‐selones, a novel class of acyclic selenonucleosides, were transformed into (tetrahydroxybutylimidazol‐2‐yl)diselenide, by acetylation and chemoselective N‐deacetylation with methanolic imidazole. Furthermore, the synthesis of a new class of conformationally restricted arabino‐configured spironucleosides containing an imidazolidine‐2‐selone unit around the glycosidic bond was achieved, starting from N‐fructosamines, via 4‐hydroxy‐4‐tetrahydoxybutyl‐imidazolidine‐2‐selones as the key intermediates. Acetylation–deacetylation of these intermediates gave access to stable aromatic imidazoline‐2‐selones.(© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2009)
Organocatalytic Enantioselective Michael Addition of 4‐Hydroxycoumarin to α,β‐Unsaturated Ketones: A Simple Synthesis of Warfarin
Authors: Dong Zhenhua , Wang Lijia , Chen Xiaohong , Liu Xiaohua , Lin Lili , Feng Xiaoming 
Published: September 2009

AbstractA type of C2‐symmetric secondary amine amide catalysts were developed for the asymmetric Michael addition of 4‐hydroxycoumarin to α,β‐unsaturated ketones. A series of important biologically and pharmaceutically active compounds were obtained in excellent yields (up to 99 %) with high enantioselectivities (up to 89 % ee) under mild conditions. In addition, enantiopure product could be obtained by a single recrystallization. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2009)
Synthesis, Structure and Electrical Properties of Mo‐doped CeO2–Materials for SOFCs
Authors: Li Q. , Thangadurai V. 
Published: September 2009

AbstractIn this paper, we report the synthesis, structure and electrical conductivity of Mo‐doped compounds with a nominal chemical formula of Ce1–xMoxO2+δ (x = 0.05, 0.07, 0.1) (CMO). The formation of fluorite‐like structure with a small amount of Ce8Mo12O49 impurity (JCPDS Card No. 31‐0330) was confirmed using a powder X‐ray diffraction (PXRD). The fluoride‐type structure was retained under wet H2 and CH4 atmospheres at 700 and 800 °C, while diffraction peaks due to metal Mo were observed in dry H2 under the same condition. AC impedance measurements showed that the total conductivity increases with increasing Mo content in CMO, and among the investigated samples, Ce0.9Mo0.1O2+δ exhibited the highest electrical conductivity with a value of 2.8 × 10–4 and 5.08 × 10–2 S cm–1 at 550 °C in air and wet H2, respectively. The electrical conductivity was found to be nearly the same, especially at high temperatures, in air, O2 and N2. Chemical compatibility of Ce0.9Mo0.1O2+δ with 10 mol‐% Y2O3 stabilised ZrO2 (YSZ) and Ce0.9Gd0.1O1.95 (CGO) oxide ion electrolytes in wet H2 was evaluated at 800–1,000 °C, using PXRD and EDX analyses. PXRD showed that CMO was found to react with YSZ electrolyte at 1,000 °C. The area specific polarisation resistance (ASPR) of Ce0.9Mo0.1O2+δ on YSZ was found to be 8.58 ohm cm2 at 800 °C in wet H2.
Two Novel Antioxidative Stilbene Tetramers from Parthenocissus laetevirens
Authors: He Shan , Jiang Liyan , Wu Bin , Zhou Jing , Pan Yuan‐Jiang 
Published: September 2009

AbstractLaetevirenols F (1) and G (2), two novel stilbene tetramers with an unprecedented skeleton, were isolated from Parthenocissus laetevirens. Their structures were elucidated by spectroscopic analysis, including 1D‐ and 2D‐NMR experiments, and their possible biogenetic pathway was discussed. In addition, both compounds were determined to be potent singlet‐oxygen quenchers by electron paramagnetic resonance (EPR) experiments, which highlights their potential pharmacological applications in singlet oxygen mediated diseases.
Three New Daphne Diterpenes from the Buds of Daphne genkwaSieb. etZucc. Processed by Rice Vinegar
Authors: Zeng Yi‐Mei , Zuo Wen‐Jian , Sun Min‐Ge , Meng He , Wang Qing‐Hui , Wang Jin‐Hui , Li Xian 
Published: September 2009

AbstractThree new Daphne diterpenes, yuanhuaoate A (1), yuanhuaoate B (2), and yuanhuaoate C (3), were isolated from the buds of Daphne genkwa Sieb. et Zucc. processed by rice vinegar. Their structures and relative configurations were established by analysis of spectroscopic data. Their absolute configurations were assigned by the CD technique, applied for the first time to Daphne diterpenes.
Seven New Phenolic Glucosides from Viburnum cylindricum
Authors: Tu Lin , Xu Gang , Zhao Yu , Peng Li‐Yan , He Juan , Guo Na , Zhao Qin‐Shi 
Published: September 2009

AbstractSeven new phenolic glucosides, 2′‐O‐acetylhenryoside (1), 2′,3′‐di‐O‐acetylhenryoside (2), 2′,6′‐di‐O‐acetylhenryoside (3), 2′,3′,6′‐tri‐O‐acetylhenryoside (4), 2′,3′,4′,6′‐tetra‐O‐acetylhenryoside (5), 2‐[(2,3‐di‐O‐acetyl‐β‐D‐glucopyranosyl)oxy]‐6‐hydroxybenzoic acid (6), and 6‐hydroxy‐2‐[(2,3,4,6‐tetra‐O‐acetyl‐β‐D‐glucopyranosyl)oxy]benzoic acid (7), were isolated from the leaves and stems of Viburnum cylindricum, along with 26 known compounds (henryoside=2‐(β‐D‐glucopyranosyloxy)‐6‐hydroxybenzoic acid [2‐(β‐D‐glucopyranosyloxy)phenyl]methyl ester). The structures of the new compounds were established on the basis of chemical and spectroscopic evidences.
Highly Efficient Synthesis of Thieno[2,3‐b]indole Derivatives
Authors: Boeini Hassan Zali 
Published: September 2009

AbstractThieno[2,3‐b]indole derivatives were efficiently prepared via the reaction of 1,3‐dihydro‐2H‐indole‐2‐thiones with α‐bromo‐substituted ketones or aldehydes and in the presence of Et3N (Scheme 2 and Table). The reaction took place under very mild conditions and in short times with good to excellent yields.
Alkyl‐Group Selection in an Acidic‐Surfactant‐Promoted Reaction of Homoallyl Alcohols and Aldehydes in Water
Authors: Hatakeyama Takanori , Chisaka Yuki , Kuroda Chiaki 
Published: September 2009

AbstractThe hydrophobic effect in the reaction of a homoallyl alcohol with an aldehyde (Yadav's reaction system) under aqueous conditions in the presence of an acidic surfactant was studied indicating the presence of the alkyl‐substituent effect, although not a dramatic one. The DBSA‐promoted reaction proceeds relatively faster when both the homoallyl alcohol and the aldehyde carry a cycloalkyl group (DBSA=4‐dodecylbenzenesulfonic acid). In contrast, the reaction of the substrates having an unbranched alkyl group is relatively more favorable in SDS/HCl than in DBSA (SDS=sodium dodecyl sulfate).
First Synthesis and Utilization of Oripavidine – A Concise and Efficient Route to Important Morphinans and Apomorphines
Authors: Sipos Attila , Berényi Sándor , Antus Sándor 
Published: September 2009

AbstractThe synthesis and transformation of oripavidine (8) offer an efficient and simple route to highly active dopamine agonist apomorphines and a variety of important 14β‐hydroxy‐morphinan derivatives. Natural origin thebaine (6), the starting compound of the procedure, was converted into its N‐{[1,2‐bis(ethoxycarbonyl)hydrazinyl]methyl} counterpart. L‐Selectride was found to be an efficient agent to perform a one‐pot O‐ and N‐deprotection at positions 3 and 17, respectively.
The Structure and Configuration of Novel Polycyclic Products Derived from an Alicyclic 1,5,9‐Trione and Binucleophiles
Authors: Kravchenko Natalia S. , Denisenko Vladimir A. , Akimova Taisia I. 
Published: September 2009

AbstractAs a continuation of our research of reactions with alicyclic 1,5,9‐trione 1 and its polycyclic form 2, we have studied their reactions with binucleophiles, e.g., phenylene‐1,2‐diamine and 2‐aminophenol, leading to novel N,O‐containing polycyclic compounds. Trione 1 formed double cyclization products 11 and 12 with 2‐aminophenol and triple cyclization product 15 with phenylene‐1,2‐diamine. Hemiacetal 2 and its dehydration product 5 reacted with binucleophiles through initial isomerization into the intermediate cyclic form 4 of trione 1. Thus, ketone 5 reacted with 2‐aminophenol stereoselectively unlike the hemiacetal 2. The structure and configuration of the reaction products were studied by using advanced spectroscopic techniques including 1D‐ and 2D‐NMR experiments.
Novel and Highly Effective Method for the Trimethylsilylation of Alcohols and Phenols with Hexamethyldisilazane (HMDS), Catalyzed by I2 Generated in situ Using Fe(NO3)3⋅9 H2O/NaI under Heterogeneous and Neutral Conditions
Authors: Khazaei Ardeshir , Rahmati Sadegh , Rostami Amin 
Published: September 2009

AbstractStructurally diverse alcohols and phenols were trimethylsilylated in a clean and efficient reaction with hexamethyldisilazane (HMDS) based on the use of I2 generated in situ from Fe(NO3)3⋅9 H2O/NaI. The reaction occurs very rapid in good‐to‐high yield in CH2Cl2 at room temperature, and the use of toxic and corrosive molecular I2 is avoided.
Tri‐ and Bicyclic Taxoids from the Taiwanese Yew Taxus sumatrana
Authors: Luh Lon‐Je , El‐Razek Mohamed H. Abd , Liaw Chia‐Ching , Chen Chen‐Tung Arthur , Lin Yun‐Sheng , Kuo Yao‐Haur , Chien Ching‐Te , Shen Ya‐Ching 
Published: September 2009

AbstractFive new taxoids, including a new 2(3→20)‐abeo‐taxane with a 6/10/6‐membered ring system and four 3,8‐seco‐taxanes having a 6/12‐membered ring system, were isolated from an acetone extract of the leaves and twigs of the Taiwanese yew (Taxus sumatrana, Taxaceae). The structures were established as 2α,7β,10α‐triacetoxy‐5α‐hydroxy‐2(3→20)‐abeo‐taxa‐4(20),11‐dien‐9,13‐dione (1), (3E,8E)‐2α,9,10β, 13α,20‐pentaacetoxy‐7β‐hydroxy‐3,8‐secotaxa‐3,8,11‐trien‐5‐one (2), (3E,8E)‐2α,9,10β,13α,20‐pentaacetoxy‐5α,7β‐dihydroxy‐3,8‐secotaxa‐3,8,11‐triene (3), (3E,8E)‐9,10β,13α‐triacetoxy‐2α,7β,20‐trihydroxy‐5α‐[(2E)‐cinnamoyloxy]‐3,8‐secotaxa‐3,8,11‐triene (4), and (3E,8E)‐2α,5α,7β,9,10β,13α‐hexaacetoxy‐20‐hydroxy‐3,8‐secotaxa‐3,8,11‐triene (5), respectively, on the basis 1D‐ and 2D‐NMR spectral analyses. The in vitro cytotoxic activity of compounds 1–5 against four human tumor cell lines, including HeLa (cervical epitheloid), WiDr (colon), Daoy (medulloblastoma), and Hep2 (liver carcinoma) tumor cells was evaluated. Whereas compounds 1–3 were inactive, the novel taxanes 4 and 5 showed significant cytotoxicity.
Structures of the Reactive Intermediates in Organocatalysis with Diarylprolinol Ethers
Authors: Grošelj Uroš , Seebach Dieter , Badine D. Michael , Schweizer W. Bernd , Beck Albert K. , Krossing Ingo , Klose Petra , Hayashi Yujiro , Uchimaru Tadafumi 
Published: September 2009

AbstractStructures of the reactive intermediates (enamines and iminium ions) of organocatalysis with diarylprolinol derivatives have been determined. To this end, diarylprolinol methyl and silyl ethers, 1, and aldehydes, PhCH2CHO, tBuCH2CHO, PhCH=CHCHO, are condensed to the corresponding enamines, A and 3 (Scheme 2), and cinnamoylidene iminium salts, B and 4 (Scheme 3). These are isolated and fully characterized by melting/decomposition points, [α]D, elemental analysis, IR and NMR spectroscopy, and high‐resolution mass spectrometry (HR‐MS). Salts with BF4, PF6, SbF6, and the weakly coordinating Al[OC(CF3)3]4 anion were prepared. X‐Ray crystal structures of an enamine and of six iminium salts have been obtained and are described herein (Figs. 2 and 4–8, and Tables 2 and 7) and in a previous preliminary communication (Helv. Chim. Acta 2008, 91, 1999). According to the NMR spectra (in CDCl3, (D6)DMSO, (D6)acetone, or CD3OD; Table 1), the major isomers 4 of the iminium salts have (E)‐configuration of the exocyclic NC(1′) bond, but there are up to 11% of the (Z)‐isomer present in these solutions (Fig. 1). In all crystal structures, the iminium ions have (E)‐configuration, and the conformation around the exocyclic N‐CC‐O bond is synclinal‐exo (cf. C and L), with one of the phenyl groups over the pyrrolidine ring, and the RO group over the π‐system. One of the meta‐substituents (Me in 4b, CF3 in 4c and 4e) on a 3,5‐disubstituted phenyl group is also located in the space above the π‐system. DFT Calculations at various levels of theory (Tables 3–6) confirm that the experimentally determined structures (cf. Fig. 10) are by far (up to 8.3 kcal/mol) the most stable ones. Implications of the results with respect to the mechanism of organocatalysis by diarylprolinol derivatives are discussed.
The influence of combinations of oximes on the reactivating and therapeutic efficacy of antidotal treatment of tabun poisoning in rats and mice
Authors: Kassa Jiri , Karasova Jana Zdarova , Pavlikova Ruzena , Misik Jan , Caisberger Filip , Bajgar Jiri 
Published: September 2009

AbstractThe influence of the combination of oximes on the reactivating and therapeutic efficacy of antidotal treament of acute tabun poisoning was evaluated. The ability of two combinations of oximes (HI‐6 + obidoxime and HI‐6 + K203) to reactivate tabun‐inhibited acetylcholinesterase and reduce acute toxicity of tabun was compared with the reactivating and therapeutic efficacy of antidotal treatment involving single oxime (HI‐6, obidoxime, K203) using in vivo methods. Studies determining percentage of reactivation of tabun‐inhibited blood and tissue acetylcholinesterase in poisoned rats showed that the reactivating efficacy of both combinations of oximes is higher than the reactivating efficacy of the most effective individual oxime in blood and diaphragm and comparable with the reactivating effects of the most effective individual oxime in brain. Moreover, both combinations of oximes were found to be slightly more efficacious in the reduction of acute lethal toxic effects in tabun‐poisoned mice than the antidotal treatment involving individual oxime. A comparison of reactivating and therapeutic efficacy of individual oximes showed that the newly developed oxime K203 is slightly more effective than commonly used obidoxime and both of them are markedly more effective than the oxime HI‐6. Based on the obtained data, we can conclude that the antidotal treatment involving chosen combinations of oximes brings beneficial effects for the potency of antidotal treatment to reactivate tabun‐inhibited acetylcholinesterase in rats and to reduce acute toxicity of tabun in mice. Copyright © 2009 John Wiley & Sons, Ltd.