bluuebunny/crossref_metadata_2025_split huggingface dataset:
Bioinformatic Analysis Reveals the Association of Human N-Terminal Acetyltransferase Complexes with Distinct Transcriptional and Post-Transcriptional Processes
Authors: Koufaris C. , Demetriadou C. , Nicolaidou V. , Kirmizis A. 
Published: June 2024

AbstractN-terminal acetyltransferases (NAT) are the protein complexes that deposit the abundant N-terminal acetylation (Nt-Ac) on eukaryotic proteins, with seven human complexes currently identified. Despite the increasing recognition of their biological and clinical importance, NAT regulation remains elusive. In this study, we performed a bioinformatic investigation to identify transcriptional and post-transcriptional processes that could be involved in the regulation of human NAT complexes. First, co-expression analysis of independent transcriptomic datasets revealed divergent pathway associations for human NAT, which are potentially connected to their distinct cellular functions. One interesting connection uncovered was the coordinated regulation of the NatA and proteasomal genes in cancer and immune cells, confirmed by analysis of multiple datasets and in isolated primary T cells. Another distinctive association was of NAA40 (NatD) with DNA replication, in cancer and non-cancer settings. The link between NAA40 transcription and DNA replication is potentially mediated through E2F1, which we have experimentally shown to bind the promoter of this NAT. Second, the coupled examination of transcriptomic and proteomic datasets revealed a much greater intra-complex concordance of NAT subunits at the protein compared to the transcript level, indicating the predominance of post-transcriptional processes for achieving their coordination. In agreement with this concept, we also found that the effects of somatic copy number alterations affecting NAT genes are attenuated post-transcriptionally. In conclusion, this study provides novel insights into the regulation of human NAT complexes.
Comparative analysis of the addition of empagliflozin versus doubling the furosemide dose in decompensated heart failure
Authors: Polat Fuat , Kaya Zeynettin , Süleymanoğlu Cuma 
Published: June 2024

Abstract
Introduction
This study aims to compare the addition of SGLT2 inhibitors or doubling the diuretic dose in patients receiving treatment with beta-blockers, angiotensin-converting enzyme inhibitors (ACEi), or angiotensin receptor blockers (ARB), as well as mineralocorticoid receptor antagonists (MRA), for heart failure with reduced ejection fraction (HFrEF) who present to the emergency department with decompensated heart failure.

Methods
This study is a single-center and prospective analysis. A total of 980 decompensated heart failure (HFrEF) patients receiving optimal medical therapy (OMT) according to the 2021 European heart failure guidelines were randomized in a 2:1 ratio into the furosemide and empagliflozin treatment arms. The analysis includes patient clinical characteristics, laboratory results, and echocardiographic data. Factors influencing rehospitalization were identified through multivariate Cox regression analysis. Log-rank analysis was employed to assess factors affecting rehospitalization.

Results
The mean age of the patients was 67.9 years, with 52.1% being men. There was no significant impact of demographic, clinical, or echocardiographic factors on rehospitalization at 1 month; only the effect of treatment subgroups on rehospitalization was observed (p = 0.039). Significant echocardiographic and clinical improvements were seen in both treatment arms. The empagliflozin group exhibited significant improvements in 6-min walk distance, heart rate, body weight, NT-pro BNP levels, and eGFR level compared to the furosemide group. The rate of rehospitalization in the first month was significantly lower in those receiving empagliflozin (28.7%) compared to those receiving a double dose of furosemide (40.2%) (log-rank p = 0.013).

Discussion and conclusion
This study provides valuable insights into the management of decompensated HFrEF and demonstrates that SGLT2 inhibitors offer benefits beyond glycemic control in this patient group. The significant reduction in rehospitalization rates and improvements in echocardiographic parameters underscore the potential of SGLT2 inhibitors in reducing acute heart failure episodes.
Cardioprotection with Intralipid During Coronary Artery Bypass Grafting Surgery on Cardiopulmonary Bypass: A Randomized Clinical Trial
Authors: Hadebe Nkanyiso , Cour Martin , Imamdin Aqeela , Petersen Tarra , Pennel Timothy , Scherman Jacques , Snowball Jane , Ntsekhe Mpiko , Zilla Peter , Swanevelder Justiaan , Lecour Sandrine 
Published: June 2024

Abstract
Purpose
Coronary artery bypass grafting (CABG) on cardiopulmonary bypass (CPB) is associated with myocardial ischemia–reperfusion injury (IRI), which may limit the benefit of the surgery. Both experimental and clinical studies suggest that Intralipid, a lipid emulsion commonly used for parenteral nutrition, can limit myocardial IRI. We therefore aimed to investigate whether Intralipid administered at reperfusion can reduce myocardial IRI in patients undergoing CABG on CPB.

Methods
We conducted a randomized, double-blind, pilot trial in which 29 adult patients scheduled for CABG were randomly assigned (on a 1:1 basis) to receive either 1.5 ml/kg Intralipid 20% or Ringer’s Lactate 3 min before aortic cross unclamping. The primary endpoint was the 72-h area under the curve (AUC) for troponin I.

Results
Of the 29 patients randomized, 26 were included in the study (two withdrew consent and one was excluded before surgery). The 72-h AUC for troponin I did not significantly differ between the control and Intralipid group (546437 ± 205518 versus 487561 ± 115724 arbitrary units, respectively; P = 0.804). Other outcomes (including 72-h AUC for CK-MB, C-reactive protein, need for defibrillation, time to extubation, length of ICU and hospital stay, and serious adverse events) were similar between the two groups.

Conclusion
In patients undergoing CABG on CPB, Intralipid did not limit myocardial IRI compared to placebo.

Trial Registration
ClinicalTrials.gov Identifier: NCT02807727 (registration date: 16 June 2016).
Densities and Molar Volumes for Binary Solutions of Tri-iso-Amyl Phosphate and n-Dodecane in the Temperature Range of 283.15–363.15 K
Authors: Kumar Shekhar 
Published: June 2024

AbstractTri-n-butyl phosphate (TBP) has remained workhorse of PUREX based nuclear recycle operations since 1956. However due to its associated disadvantages like third phase formation and tendency to react violently with nitric acid at elevated temperatures generated requirement of an alternate extractant for PUREX process. Tri-iso-amyl phosphate (TiAP) has better attributes than TBP on both the counts. Density of solutions is an important process parameter for design of equipment, process operations and control and safety analysis. In this work, experimental data on the density of binary solution of tri-iso amyl phosphate and n-dodecane are reported for several temperature levels. The related volumetric parameters were also estimated from experimental data as well as Kirkwood–Buff integrals. Derivative parameters like linear coefficients of preferential solvation $$\delta_{ij(i \ne j)}^{o}$$

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j
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o

and local mole fractions $$x_{ij(i \ne j)}$$

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j
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at 298.15 K were also estimated and reported.
Graphical Abstract
Building Better Bridges: Outcomes of a Community-Partnered New School Transition Intervention for Students on the Autism Spectrum
Authors: Nuske Heather J. , Smith Tristram , Levato Lynne , Bronstein Briana , Sparapani Nicole , Garcia Consuelo , Castellon Fernanda , Lee Hyon Soo , Vejnoska Sarah F. , Hochheimer Samantha , Fitzgerald Amber R. , Chiappe Jenny C. , Nunnally Amanda Dimachkie , Li Jennica , Shih Wendy , Brown Ashlee , Cullen Michelle , Hund Lisa M. , Stahmer Aubyn C. , Iadarola Suzannah , Mandell David S. , Hassrick Elizabeth McGhee , Kataoka Sheryl , Kasari Connie 
Published: June 2024

AbstractNew school transitions can be challenging for students on the autism spectrum. No published, evidence-based interventions exist to support families and teachers of students transitioning to elementary and secondary school during this critical period. Using Community Partnered Participatory Research, we developed Building Better Bridges (BBB), a caregiver coaching intervention that includes training on effective school communication, educational rights, advocacy, and child preparation strategies. We compared BBB (n = 83) to a module/resources-only comparison (n = 87) in a four-site randomized controlled trial in racially and ethnically diverse, under-resourced communities. In our intent-to-treat analysis, caregivers and teachers in BBB rated students’ transitions to the new classroom as more positive, relative to the comparison group. Results suggest this low-cost intervention can improve the transition process for families and students at high risk of poor transitions.
Large-scale school improvement: results of and conditions for systemic changes within coupled school systems
Authors: Adolfsson Carl-Henrik 
Published: June 2024

AbstractThe aim of this study was to explore the results of and conditions for systemic large-scale school improvement. Through a multi-level analysis and a theoretical framework inspired by organization- and sensemaking-oriented theories, the study examines how a Swedish large-scale school improvement program, “Collaboration for the Best School Possible,” played out in two Swedish municipalities. School actors at four organizational levels (at the National Education Agency, Local Education Authority, school leader, and teacher levels) in the two municipalities were interviewed. Because these school actors’ sensemaking is linked to different aspects of the national largescale improvement program, the analysis shows a variation in the strengthening of the couplings between these organizational levels. The different nature of the couplings affected the implementation process and the results of the program. While the national large-scale program seemed to have contributed to an improvement in the schools’ quality assurance systems and leadership practices, there were difficulties in maintaining general and sustainable changes in schools’ instructional practices. The conclusion of the study was that, even if a national large-scale school improvement program is well designed and backed up with many resources, it must be perceived as legitimate among the local school actors at the different organizational levels. This points to the importance of managing the balance between top-down efforts and visions and local professional knowledge and experience.
A light-detecting Ru(II)/Si heterojunction system involving a binuclear Ru (II) complex with pyridine-2,6-diimine (pydim) ligand
Authors: Koç Mümin Mehmet , Dayan Osman , Dere Ayşegul , Çetinkaya Bekir , Coşkun Burhan , Yakuphanoğlu Fahrettin 
Published: June 2024

AbstractA meticulously detailed chemical procedure was employed to synthesize the Ru (II)-containing pyridine-2,6-diimine (pydim) organometallic complex. The resulting complex was then applied to Al-coated Si wafers using the spin-coating technique, leading to the production of Al/Ru(II) organometallic complex/n-Si/Al photodiodes. The light responsiveness of these photodiodes was demonstrated through the acquisition of I-V and I-t characteristics. Subsequently, essential parameters such as ideality factor, photosensitivity, barrier height, and photoresponse values were evaluated based on the obtained I-V and I-t plots. The calculations yielded ideality factors and barrier heights, resulting in average values of 6.41 and 0.552 eV, respectively. Furthermore, an in-depth analysis of the electrical properties of the diodes was conducted using G-V and C-V assessments, revealing a strong dependence on AC signal frequency. This investigation underscored that the observed frequency-related electrical behaviour is rooted in series resistance and interface states.
“Close to the Problem” or “Close to Your Problem”? The Contribution of Bond to the Structure of Early and Advanced Therapeutic Alliance
Authors: Prusiński Tomasz 
Published: June 2024

AbstractThe study analyzed the contribution of bond in the structure of the therapeutic alliance. Results were reported for two stages of the psychotherapeutic process: early and advanced. The study included 415 psychotherapist–patient dyads in the process of individual psychotherapy. Alliance estimation was based on Bordin’s model of alliance. The hypothesis was tested through structural equation modeling analysis. In both the early and advanced phases of psychotherapy, patient–therapist bond made a large contribution to the structure of the alliance, similar to that of the remaining two components: goals and tasks. The results indicate that bond is a crucial and permanent element in the structure of the relationship in the psychotherapeutic dyad, regardless of the stage of the process. In the advanced phase, the distance in weight between bond and the remaining two dimensions of alliance is minimal. The contribution of bond to the alliance structure as high as the contributions of goals and tasks signals not only the importance of understanding the patient’s problem but also the importance of mutual trust and respect.
People Attribute a Range of Highly-Varied and Socially-Bound Meanings to Naturalistic Sad Facial Expressions
Authors: de la Harpe Sarah , Palermo Romina , Brown Emily , Fay Nicolas , Dawel Amy 
Published: June 2024

AbstractDepictions of sadness are commonplace, and here we aimed to discover and catalogue the complex and nuanced ways that people interpret sad facial expressions. We used a rigorous qualitative methodology to build a thematic framework from 3,243 open-ended responses from 41 people who participated in 2020 and described what they thought sad expressors in 80 images were thinking, feeling, and/or intending to do. Face images were sourced from a novel set of naturalistic expressions (ANU Real Facial Expression Database), as well as a traditional posed expression database (Radboud Faces Database). The resultant framework revealed clear themes around the expressors’ thoughts (e.g., acceptance, contemplation, disbelief), social needs (e.g., social support or withdrawal), social behaviours/intentions (e.g., mock or manipulate), and the precipitating events (e.g., social or romantic conflict). Expressions that were perceived as genuine were more frequently described as thinking deeply, reflecting, or feeling regretful, whereas those perceived as posed were more frequently described as exaggerated, overamplified, or dramatised. Overall, findings highlight that facial expressions — even with high levels of consensus about the emotion category they belong to — are interpreted in nuanced and complex ways that emphasise their role as other-oriented social tools, and convey semantically related emotion categories that share smooth gradients with one another. Our novel thematic framework also provides an important foundation for future work aimed at understanding variation in the social functions of sadness, including exploring potential differences in interpretations across cultural settings.
Towards a platform-portable linear algebra backend for OpenFOAM
Authors: Olenik Gregor , Koch Marcel , Boutanios Ziad , Anzt Hartwig 
Published: June 2024

AbstractGraphics processing unit accelerators have become a widespread technology on modern high performance computing clusters for increasing the performance of scientific computing algorithms. Despite early efforts to adopt linear solvers that utilize graphics processing units for OpenFOAM, to this date no widely accepted approach has gotten traction. In recent years, the number of different vendors providing graphics processing units accelerators has grown, and as of the writing of this paper, no commonly accepted, unified approach to leverage accelerators exists. This makes platform-portable solutions to increase the efficiency of graphics processing units offloading techniques desirable, and an important research topic. In this work, we investigate a platform-portable solution using the Ginkgo sparse linear algebra library.
Impact of optimizers functions on detection of Melanoma using transfer learning architectures
Authors: Kılıçarslan Serhat , Aydın Hatice Aktas , Adem Kemal , Yılmaz Esra Kavalcı 
Published: June 2024

AbstractEarly diagnosis-treatment of melanoma is very important because of its dangerous nature and rapid spread. When diagnosed correctly and early, the recovery rate of patients increases significantly. Physical methods are not sufficient for diagnosis and classification. The aim of this study is to use a hybrid method that combines different deep learning methods in the classification of melanoma and to investigate the effect of optimizer methods used in deep learning methods on classification performance. In the study, Melanoma detection was carried out from the skin lesions image through a simulation created with the deep learning architectures DenseNet, InceptionV3, ResNet50, InceptionResNetV2 and MobileNet and seven optimizers: SGD, Adam, RmsProp, AdaDelta, AdaGrad, Adamax and Nadam. The results of the study show that SGD has better and more stable performance in terms of convergence rate, training speed and performance than other optimizers. In addition, the momentum parameter added to the structure of the SGD optimizer reduces the oscillation and training time compared to other functions. It was observed that the best melanoma detection among the combined methods was achieved using the DenseNet model and SGD optimizer with a test accuracy of 0.949, test sensitivity 0.9403, and test F score 0.9492.
Azole Resistance in Veterinary Clinical Aspergillus fumigatus Isolates in the Netherlands
Authors: van Dijk Marloes A. M. , Buil Jochem B. , Tehupeiory-Kooreman Marlou , Broekhuizen Marian J. , Broens Els M. , Wagenaar Jaap A. , Verweij Paul E. 
Published: June 2024

AbstractAspergillus fumigatus is a saprophytic fungal pathogen that causes opportunistic infections in animals and humans. Azole resistance has been reported globally in human A. fumigatus isolates, but the prevalence of resistance in isolates from animals is largely unknown. A retrospective resistance surveillance study was performed using a collection of clinical A. fumigatus isolates from various animal species collected between 2015 and 2020. Agar-based azole resistance screening of all isolates was followed by in vitro antifungal susceptibility testing and cyp51A gene sequencing of the azole-resistant isolates. Over the 5 year period 16 (11.3%) of 142 A. fumigatus culture-positive animals harbored an azole-resistant isolate. Resistant isolates were found in birds (15%; 2/13), cats (21%; 6/28), dogs (8%; 6/75) and free-ranging harbor porpoise (33%; 2/6). Azole-resistance was cyp51A mediated in all isolates: 81.3% (T-67G/)TR34/L98H, 12.5% TR46/Y121F/T289A. In one azole-resistant A. fumigatus isolate a combination of C(-70)T/F46Y/C(intron7)T/C(intron66)T/M172V/E427K single-nucleotide polymorphisms in the cyp51A gene was found. Of the animals with an azole-resistant isolate and known azole exposure status 71.4% (10/14) were azole naive. Azole resistance in A. fumigatus isolates from animals in the Netherlands is present and predominantly cyp51A TR-mediated, supporting an environmental route of resistance selection. Our data supports the need to include veterinary isolates in resistance surveillance programs. Veterinarians should consider azole resistance as a reason for therapy failure when treating aspergillosis and consider resistance testing of relevant isolates.
Nonlinear spatiotemporal characteristics of wind–rain flow around the trains passing through the tunnel entrance during rainstorms
Authors: Li Guo-Zhi , E Deng  , Ni Yi-Qing , Ouyang De-Hui , Yang Wei-Chao 
Published: June 2024

AbstractTropical storms present a significant risk to the safety of high-speed trains due to the extreme wind and rainfall they bring. This study employs Eulerian multiphase and Shear-Stress Transport k-ω turbulence models for three-dimensional numerical simulations, focusing on wind–rain interactions involving tunnels, embankments, and trains. The reliability of the numerical analysis method for train slipstream pressure is verified by dynamic model test. Based on the scenario of single train running on the embankment and train intersection at the tunnel portal, the train flow around and wake are analyzed successively with different rainfall intensity. The characteristics of nonlinear wind–rain-train flow field are analyzed from the aspects of velocity field, pressure field and turbulent flow. Finally, the mechanism of the influence of rain on the relative flow field is revealed by the spatiotemporal distribution characteristics of rain phase. With the increase of rainfall intensity, the increase of rain phase distribution on the leeward side of the single train strengthened the backflow on the leeward side of the train. Under the condition of the trains intersecting at the tunnel portal, the relatively closed area between the train and the water film weakened the slipstream effect of the train.
Bifurcation in an modified model of neutrophil cells with time delay
Authors: Ma S. Q. , Hogan S. J. 
Published: June 2024

AbstractThe hematological stem cells model is introduced with neutrophil dynamics of two department model setting forth. During the cells differentiation and proliferation process, the neutrophils are functioned with negative feedback with delay history, which contains delayed amplification coefficient. In more general view, the new introduction rate is given to replace the familiar Hill function which is helpful to understand the complex dynamics of neutrophils. The double Hopf bifurcation is calculated with the artificial handtools named DDE-Biftool, which is observed as the self-intersection of Hopf lines. The continuation of periodical solutions arising from Hopf points are done and the longer period solutions are manifested with multi-rhythm and bursting oscillation. The near dynamics of double Hopf points is simulated by DDE-Biftool with different route design, the multi-period attractors, quasi-periodical solutions and chaos are observed.
Unpacking the relationship between sense of place and entrepreneurs’ well-being
Authors: Kautonen Teemu , Soto-Simeone Aracely , Kibler Ewald 
Published: June 2024

AbstractThis exploratory study develops an understanding of how the hitherto under-investigated psychological dimension of place affects entrepreneurs’ well-being. The analysis focuses on eudaimonic well-being, which describes individuals’ psychological functioning and fulfillment of their best potentials and is relatively underexplored compared to hedonic well-being (happiness). Based on prior work in environmental psychology, the study proposes that entrepreneurs’ sense of place—their psychological bond with the local setting of their entrepreneurial activities—is an important component influencing their well-being. The empirical analysis of two waves of original survey data from entrepreneurs located in an urban and a rural region of Finland shows that the sense of place is positively associated with several dimensions of eudaimonic well-being. This study extends the literature by shifting the focus from place as a passive container for entrepreneurs’ activities to its role as an active source of entrepreneurial well-being.