bluuebunny/crossref_metadata_2025_split huggingface dataset:
A 12.5‐kyr history of vegetation dynamics and mire development with evidence of Younger Dryas larch presence in the Verkhoyansk Mountains, East Siberia, Russia
Authors: WERNER KIRSTIN , TARASOV PAVEL E. , ANDREEV ANDREI A. , MÜLLER STEFANIE , KIENAST FRANK , ZECH MICHAEL , ZECH WOLFGANG , DIEKMANN BERNHARD 
Published: September 2009

Werner, K., Tarasov, P. E., Andreev, A. A., Müller, S., Kienast, F., Zech, M., Zech, W. & Diekmann, B. 2009: A 12.5‐kyr history of vegetation dynamics and mire development with evidence of Younger Dryas larch presence in the Verkhoyansk Mountains, East Siberia, Russia. Boreas, 10.1111/j.1502‐3885.2009.00116.x. ISSN 0300‐9483.A 415 cm thick permafrost peat section from the Verkhoyansk Mountains was radiocarbon‐dated and studied using palaeobotanical and sedimentological approaches. Accumulation of organic‐rich sediment commenced in a former oxbow lake, detached from a Dyanushka River meander during the Younger Dryas stadial, at ∼12.5 kyr BP. Pollen data indicate that larch trees, shrub alder and dwarf birch were abundant in the vegetation at that time. Local presence of larch during the Younger Dryas is documented by well‐preserved and radiocarbon‐dated needles and cones. The early Holocene pollen assemblages reveal high percentages of Artemisia pollen, suggesting the presence of steppe‐like communities around the site, possibly in response to a relatively warm and dry climate ∼11.4–11.2 kyr BP. Both pollen and plant macrofossil data demonstrate that larch woods were common in the river valley. Remains of charcoal and pollen of Epilobium indicate fire events and mark a hiatus ∼11.0–8.7 kyr BP. Changes in peat properties, C31/C27 alkane ratios and radiocarbon dates suggest that two other hiatuses occurred ∼8.2–6.9 and ∼6.7–0.6 kyr BP. Prior to 0.6 kyr BP, a major fire destroyed the mire surface. The upper 60 cm of the studied section is composed of aeolian sands modified in the uppermost part by the modern soil formation. For the first time, local growth of larch during the Younger Dryas has been verified in the western foreland of the Verkhoyansk Mountains (∼170 km south of the Arctic Circle), thus increasing our understanding of the quick reforestation of northern Eurasia by the early Holocene.
The Importance of dQ/dt on the Flow Field in a Turbodynamic Pump With Pulsatile Flow
Authors: Shu Fangjun , Vandenberghe Stijn , Antaki James F. 
Published: September 2009

AbstractFluid dynamic analysis of turbodynamic blood pumps (TBPs) is often conducted under steady flow conditions. However, the preponderance of clinical applications for ventricular assistance involves unsteady, pulsatile flow—due to the residual contractility of the native heart. This study was undertaken to demonstrate the importance of pulsatility and the associated time derivative of the flow rate (dQ/dt) on hemodynamics within a clinical‐scale TBP. This was accomplished by performing flow visualization studies on a transparent model of a centrifugal TBP interposed within a cardiovascular simulator with controllable heart rate and stroke volume. Particle image velocimetry triggered to both the rotation angle of the impeller and phase of the cardiac cycle was used to quantify the velocity field in the outlet volute and in between the impeller blades for 16 phases of the cardiac cycle. Comparison of the unsteady flow fields to corresponding steady conditions at the same (instantaneous) flow rates revealed marked differences. In particular, deceleration of flow was found to promote separation within the outlet diffuser, while acceleration served to stabilize the velocity field. The notable differences between the acceleration and deceleration phases illustrated the prominence of inertial fluid forces. These studies emphasize the importance of dQ/dt as an independent variable for thorough preclinical validation of TBPs intended for use as a ventricular assist device.
Baroreflex Sensitivity of an Arterial Wall During Rotary Blood Pump Assistance
Authors: Yambe Tomoyuki , Imachi Kou , Shiraishi Yasuyuki , Yamaguchi Tasuku , Shibata Mune‐ichi , Kameyama Takeshi , Yoshizawa Makoto , Sugita Norihiro 
Published: September 2009

AbstractIt is well known that the baroreflex system is one of the most important indicators of the pathophysiology in hypertensive patients. We can check the sensitivity of the baroreflex by observing heart rate (HR) responses; however, there is no simple diagnostic method to measure the arterial behavior in the baroreflex system. Presently, we report the development of a method and associated hardware that enables the diagnosis of baroreflex sensitivity by measuring the responses of both the heart and the artery. In this system, the measurements are obtained by monitoring an electrocardiogram and a pulse wave recorded from the radial artery or fingertip. The arterial responses were measured in terms of the pulse wave velocity (PWV) calculated from the pulse wave transmission time (PTT) from the heart to the artery. In this system, the HR change corresponding to the blood pressure change in time series sequence was observed. Slope of the changes in blood pressure and HR indicated the sensitivity of the baroreflex system of the heart. This system could also measure the sensitivity of the baroreflex system of an artery. Changes in the PWV in response to the blood pressure changes were observed. Significant correlation was observed in the time sequence between blood pressure change and PWV change after calculating the delay time by cross‐correlation. The slope of these parameter changes was easily obtained and it demonstrated the sensitivity of the baroreflex system of an artery. We evaluated this method in animal experiments using rotary blood pump (RBP) with undulation pump ventricular assist device, and PTT elongation was observed in response to increased blood pressure with RBP assistance. Furthermore, when tested clinically, decreased sensitivity of the baroreflex system in hypertensive patients was observed. This system may be useful when we consider the ideal treatment and follow‐up of patients with hypertension.
Glucose Depletion Enhances Sensitivity to Shear Stress‐induced Mechanical Damage in Red Blood Cells by Rotary Blood Pumps
Authors: Sakota Daisuke , Sakamoto Ryuki , Yokoyama Naoyuki , Kobayashi Mariko , Takatani Setsuo 
Published: September 2009

AbstractThe metabolic process in red blood cells (RBCs) is anaerobic. The life‐dependent adenosine triphosphate (ATP) for survival of cells is produced through glycolytic process. The aim of the study was to evaluate the effects of the glucose level on the mean corpuscular volume, mean corpuscular hemoglobin concentration, and hemolysis rate during hemolysis study by rotary blood pumps. The shear stress generated by rotary blood pumps may enhance glucose utilization by RBCs with depletion of glucose affecting ATP production and, consequently, cell size, shape, and morphology. The shear stress increases metabolism of RBCs consuming more energy ATP which is produced anaerobically from glycolytic process. Hence, in the closed circuit testing of rotary blood pumps, depletion of glucose might occur after prolonged pumping, which in turn affects metabolic process of RBCs by changing their size, shape, and morphology. It is thus suggested to monitor and control the glucose level of the fluid that suspends RBCs depending on the study duration.
Relationship Between Avifaunal Occupancy and Riparian Vegetation in the Central Great Basin (Nevada, U.S.A.)
Authors: Dickson Brett G. , Fleishman Erica , Dobkin David S. , Hurteau Sarah R. 
Published: September 2009

AbstractIn western North America, riparian vegetation is being lost in response to changes in land use and climate. We examined the relationship between obligate riparian species of songbirds and environmental and riparian habitat factors in three mountain ranges in the central Great Basin (Nevada, U.S.A.). We estimated patterns of occupancy, colonization, and local extinction for three species detected during the breeding seasons of 2001–2006: MacGillivray's Warbler (Oporornis tolmiei), Broad‐tailed Hummingbird (Selasphorus platycercus), and Song Sparrow (Melospiza melodia). We used model selection and multimodel inference to identify functional relationships between the occupancy of each species and multiple habitat variables, including the structure and composition of riparian vegetation. Among all years and species, we observed considerable variation in estimates of detection probability. For MacGillivray's Warbler, annual occupancy rates were relatively constant. Occupancy rates for Broad‐tailed Hummingbird and Song Sparrow increased during the first 3–4 years of our study and then decreased. Each species experienced its highest rate of local extinction during 2005. Different components of riparian vegetation were good predictors of occupancy, colonization, and local extinction for each species. Typically, elevation and latitude also were strong predictors. Establishing functional relationships between avifauna and vegetation is essential to predicting how land‐cover change may affect the occupancy of riparian areas and other habitats for birds. The conservation of breeding birds in riparian areas in the central Great Basin is more likely to succeed if the quality of their understory habitat as well as the canopy is maintained and restored.
Effects of Ethanol on Mouse Embryonic Stem Cells
Authors: Arzumanyan Alla , Anni Helen , Rubin Raphael , Rubin Emanuel 
Published: September 2009

Background:  Fetal alcohol syndrome (FAS) reflects a constellation of congenital abnormalities caused by excess maternal consumption of alcohol. It is likely that interference with embryonic development plays a role in the pathogenesis of the disorder. Ethanol‐induced apoptosis has been suggested as a causal factor in the genesis of FAS. Mouse embryonic stem (mES) cells are pluripotent cells that differentiate in vitro to cell aggregates termed embryoid bodies (EBs), wherein differentiation capacity and gene expression profile are similar to those of the early embryo.Methods:  To investigate the effects of ethanol during differentiation, mES cells were cultured on a gelatin surface in the presence of leukemia inhibitory factor which maintains adherent undifferentiated cells or in suspension to promote formation of EBs. All cells were treated (1–6 days) with 80 mM ethanol. The pluripotency and differentiation of mES cells were evaluated by western blotting of stage‐specific embryonic antigen (SSEA‐1), transcription factors Oct‐3/4, Sox‐2, and Nanog, using alkaline phosphatase staining. Apoptosis (early to late stages) was assessed by fluorescence‐activated cell sorting using TdT‐mediated biotin–dUTP nick‐end labelling assay and fluorescein isothiocyanate‐Annexin V/propidium iodide staining.Results:  Ethanol increased apoptosis during in vitro differentiation of mES cells to EBs, whereas undifferentiated cells were not affected. Ethanol exposure also interfered with pluripotency marker patterns causing an upregulation of SSEA‐1 under self‐renewal conditions. In EBs, ethanol delayed the downregulation of SSEA‐1 and affected the regulation of transcription factors during differentiation.Conclusion:  Our findings suggest that ethanol may contribute to the pathogenesis of FAS by triggering apoptotic pathways during differentiation of embryonic stem cells and deregulating early stages of embryogenesis.
Renal dysfunction due to leukemic infiltration of kidneys in a case of chronic lymphocytic leukemia
Authors: FERREIRA Ana Carina , BRUM Sandra , CARVALHO Dulce , PATACA Isabel , CARVALHO Fernanda , SANTOS Maria Céu , SANTOS João Ribeiro 
Published: September 2009

ABSTRACTRenal failure due to leukemic infiltration of kidney in chronic lymphocytic leukemia is an extremely rare condition. The authors report a case of a 59‐year‐old white female, with a past medical history of chronic lymphocytic leukemia (CLL) with 2 years of evolution without medical therapy, admitted with nonoliguric acute renal failure needing dialysis. Renal biopsy showed extensive small lymphocytes' infiltration in the cortical interstitium by CLL cells. Cyclophosphamide and prednisolone were started and 1 month later changed to fludarabine plus cyclophosphamide with improvement of renal function. Although renal failure due to leukemic infiltration has been described in many cases of acute leukemia, only 11 cases of renal failure due to CLL cells' infiltration have been described in the literature. Renal histology is an extremely important tool to confirm diagnosis.
Hemodialysis access at initiation in the United States, 2005 to 2007: Still “Catheter First”
Authors: FOLEY Robert N. , CHEN Shu‐Cheng , COLLINS Allan J. 
Published: September 2009

AbstractDespite the broad consensus that native arteriovenous fistula is the access of choice for hemodialysis, national‐level information about vascular access at dialysis initiation has been unavailable in the United States. For incident hemodialysis patients, June 2005 to October 2007 (n=220,157), vascular access type was determined from the new Centers for Medicare & Medicaid Services Medical Evidence Report (form CMS‐2728). Proportions with each type at first dialysis, demographic and clinical associations of each type, and associations between initial access type and survival were assessed. The mean patient age was 63.6 years; 29.4% of patients were African American, and for 44.5%, end‐stage renal disease was due to diabetes. Vascular access proportions were: fistula, 13.2% of patients; graft, 4.3%; catheter/maturing fistula, 16.0%; catheter/maturing graft, 3.3%; and catheter alone, 63.2%. Adjusted odds ratios (vs. fistula) of catheter use alone were ≥1.50 for lack of insurance (1.62 [95% confidence interval 1.62–1.68]), nephrologist care for 0 to 12 months (2.75 [2.69–2.81]), other (2.19 [2.09–2.29]), or unknown (1.53 [1.44–1.63]) cause of renal disease, institutional residence (1.51 [1.45–1.57]), and 7 of 18 end‐stage renal disease networks. Over a mean follow‐up of 1 year, 26.0% of the study population died. Compared with fistula, adjusted mortality hazards ratios were 1.39 (1.32–1.47) for grafts, 1.49 (1.44–1.55) for catheters/maturing fistulas, 1.74 (1.65–1.84) for catheters/maturing grafts, and 2.18 (2.11–2.26) for catheters alone. While geographic variability is pronounced, vascular access at dialysis inception is typically suboptimal; suboptimal access exhibits a graded association with mortality. Lack of timely access to specialty care appears to limit optimal access.
Streptococcus bovis bacteremia related to colon adenoma in a chronic hemodialysis patient
Authors: KAHVECI Arzu , ARI Elif , ARIKAN Hakki , KOC Mehmet , TUGLULAR Serhan , OZENER Cetin 
Published: September 2009

AbstractWe report the case of a 54‐year‐old hemodialysis patient who presented with recurrent fever due to Streptococcus bovis bacteremia related to colonic tubulovillous adenoma. Following polypectomy and broad‐spectrum antibiotic therapy, the patient totally recovered. In this paper, we discussed the relation between S. bovis bacteremia, colonic adenomas, and hemodialysis. Awareness of this association is critical for early diagnosis and management.
Serum levels of IL‐18 and sIL‐2R in patients with alopecia areata receiving combined therapy with oral cyclosporine and steroids
Authors: Lee Deborah , Hong Soon‐Kwon , Park Sung‐Wook , Hur Dae‐Young , Shon Ji‐Hong , Shin Jae‐Gook , Hwang Seon‐Wook , Sung Ho‐Suk 
Published: September 2009

Please cite this paper as: Serum levels of IL‐18 and sIL‐2R in patients with alopecia areata receiving combined therapy with oral cyclosporine and steroids. Experimental Dermatology 2010; 19: 145–147.Abstract:  This study was to determine which immunologic factors contribute to the prognosis of patients with alopecia areata (AA) who were receiving oral cyclosporine A and methylprednisolone. Patients with >25% hair regrowth were defined as responders, and patients exhibiting ≤25% regrowth were poor‐responders. The serum levels of IL‐18 and soluble IL‐2 receptor (sIL‐2R) were measured at baseline in 21 patients with AA and 22 control subjects. The mean serum level of IL‐18 in the patients with extensive AA was significantly higher than that in the control subjects. The mean serum concentration of sIL‐2R in the AA patients significantly decreased after 1 month of treatment. The mean basal serum level of IL‐18 was highest in the responder, whereas the baseline level of sIL‐2R was significantly higher in the poor‐responder group than other groups. In conclusion, increased serum sIL‐2R level and lower IL‐18 level at baseline was associated with a poor prognosis in patients with AA.
Large scale study of epidermal recovery after stratum corneum removal: dynamics of genomic response
Authors: Sextius Peggy , Marionnet Claire , Bon Francois‐Xavier , Chapelle Albane Lamy de La , Tacheau Charlotte , Lahfa Morad , Mauviel Alain , Bernard Bruno A. , Leclaire Jacques , Bernerd Francoise , Dubertret Louis 
Published: September 2009

Please cite this paper as: Large scale study of epidermal recovery after stratum corneum removal: dynamics of genomic response. Experimental Dermatology 2010; 19: 259–268.Abstract:  The stratum corneum (SC) is a superficial skin compartment that protects the body from the outside environment. Any disturbance of this function induces cascading steps of molecular and cellular repair in the whole epidermis. The aim of this study was to investigate epidermal gene expression following SC removal by tape stripping. Twenty‐nine healthy male volunteers were included (27 ± 4 years old). Tape stripping was processed on one inner forearm, the other unstripped forearm served as a control. Epidermis samples were collected at 2, 6, 19, 30 and 72 h after tape stripping. Trans‐epidermal water loss measurements were performed at each step to monitor barrier restoration. Total RNA was extracted from collected epidermis samples and analysed by using DermArray® cDNA microarrays. Among 4000 genes under investigation, we found that the expression of 370 genes varied significantly at least once during the time following stripping. Using an original clustering method, the modulated genes were gathered into eight groups. A functional characterization of the clusters enabled us to get a dynamic and global view of the main molecular processes taking place during epidermal recovery.
Fetuin‐A promotes primary keratinocyte migration: independent of epidermal growth factor receptor signalling
Authors: Wang Xue‐Qing , Hung Betsy S. , Kempf Margit , Liu Pei‐Yun , Dalley Andrew J. , Saunders Nicholas A. , Kimble Roy M. 
Published: September 2009

Please cite this paper as: Fetuin‐A promotes primary keratinocyte migration: independent of epidermal growth factor receptor signalling. Experimental Dermatology 2010; 19: e289–e292.Abstract:  Previously, we reported that fetuin‐A is a major component of ovine foetal skin and significantly enhances ‘wound closure’ in primary keratinocyte cultures. In this study, we found that in human newborn foreskin, a high level of fetuin‐A protein is detected throughout the dermis. However, in adult skin a low level of fetuin‐A is observed throughout the epidermal and dermal layers, except at regions surrounding hair follicles and at the epidermal‐dermal junction where the level of fetuin‐A is relatively high. Fetuin‐A significantly induces actin‐rich protrusions in human primary keratinocytes. Interestingly, blockade of epidermal growth factor (EGF) receptor signalling has a limited effect on fetuin‐A promoted ‘wound closure’ on primary human keratinocytes, but significantly inhibits fetuin‐A’s effect on HaCaT cells. These results indicate that high levels of fetuin‐A may partially contribute to less scar formation in newborn foreskin and that the effect of fetuin‐A on primary keratinocyte migration is independent of EGF receptor signalling.
Development of a Japanese Version of the Care Planning Assessment Tool
Authors: Kanegae Sumiko , Koizumi Shunzo , Fleming Richard , Ichimaru Norimi , Nagashio Tomoko 
Published: September 2009

Aim:  To develop a Japanese version of the Care Planning Assessment Tool (J‐CPAT), originally developed in Australia as a comprehensive assessment of people with dementia.Methods:  The process of adapting the CPAT into Japanese included translation into Japanese, assessment of item comprehension, and a validity and reliability study. The J‐CPAT is composed of eight domains: Communication, physical problems, self‐help skills, confusion, behaviour, social interaction, psychiatric observations and carer dependency. The participants were 199 aged care clients. Measures were the J‐CPAT, Mini‐Mental State Examination (MMSE) and Care Levels used in the Long‐term Care Insurance scheme.Results:  Cronbach's alpha values in each J‐CPAT domain were 0.74–0.95. The correlation coefficient between the score of Confusion and MMSE was −0.90, and those between physical problems, self‐help skills, carer dependency in the J‐CPAT, and care level were 0.70, 0.75 and 0.67.Conclusions:  The J‐CPAT appears to be a reliable and valid tool for care planning in Japan.
Patient and Partner Satisfaction after AMS Inflatable Penile Prosthesis Implant
Authors: Bettocchi Carlo , Palumbo Fabrizio , Spilotros Marco , Lucarelli Giuseppe , Palazzo Silvano , Battaglia Michele , Selvaggi Francesco Paolo , Ditonno Pasquale 
Published: September 2009

ABSTRACT

Introduction
The implantation of penile prostheses is an effective option for treating erectile dysfunction (ED), and nowadays it is used to treat those cases where pharmacological agents have not provided a useful result.

Aims
The primary aim of the present study was to verify the patient and their partner’s satisfaction, in 80 patients who underwent AMS CX 700 prostheses implant in a single center, by the same surgeon, in the period between 2004 and 2008.

Methods
In the period between March 2004 and May 2008, 80 penile prostheses implantations have been performed. Any information regarding patients has been retrospectively collected consulting their case histories stored in our archive. Each patient was followed postoperatively, and surgical complications were recorded.

Main Outcome Measure
All the patients entered in this study were contacted by phone by a single operator who asked for their consent to collect information regarding their operation, the use of the prostheses, and the couple satisfaction. Once the consent was obtained, a nine-point questionnaire was administered.

Results
Seventy-six patients (97%) affirmed to use penile prostheses frequently. Fifty-four patients (69%) and 70 partners (90%) affirmed that they never had problems with the use of the prosthesis and they considered themselves satisfied. Sixty-two patients (79%) answered that this therapeutic method has led to evident improvements in their sexual life. Sixty-two patients (79%) gave a score equal or major than seven and sixty-four partners (82%) gave a score equal or major than seven. All but two patients (97%) reported they would suggest this treatment to other people.

Conclusions
Penile prosthetic surgery constitutes a valid therapeutic alternative, capable of modifying the prognosis and the course of ED. This consideration is emphasized by the high rate of patients and partner’s satisfaction emerged in our series and in literature.