bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hindutva in the shadow of the Mahatma: M. S. Golwalkar, M. K. Gandhi, and the RSS in post-colonial India
Authors: Chaudhary Neha , Narayan Saarang 
Published: April 2024

AbstractWhile many commentators have noted the Bharatiya Janata Party’s more recent attempts at appropriating Gandhian imagery and symbolism, few have diverted their attention towards earlier attempts by Hindu Nationalists to do so. M. S. Golwalkar is the most prominent example of Hindu Nationalists who attempted to incorporate Gandhi into the pantheon of Hindutva (Hindu-ness). This article argues that Golwalkar reproduced Gandhian ideas as part of Hindu Nationalist thought, alongside carefully and consciously portraying himself as an ascetic politician, much like Gandhi, in the post-colonial leg of his career. He crafted a mode of Hindutva politics whereby his image as an extraordinarily able-bodied yogi became an archetype that was touted as a model for every swayamsevak to follow. Furthermore, the ideological shifts that are visible in Golwalkar’s later publications created greater room in Hindutva thought to incorporate Gandhi’s ideas and legacy into the Rashtriya Swayamsevak Sangh’s (RSS) ideological fold. Doing so allowed Golwalkar to tackle the challenges the RSS faced after Gandhi’s assassination. This article locates Golwalkar and the RSS in the shadow of the Mahatma to not only broaden the understanding of Gandhi’s legacy in post-colonial India but also to prompt a reappraisal of the nature of Hindutva itself. By exploring the Sangh’s deep appropriation of Gandhi’s ideas and legacy, one can begin to understand the malleable and flexible nature of the otherwise narrow majoritarian Hindu Nationalist project.
Delegating legislative powers to the European Commission: the threat of non-compliance with tertiary legislation in the member states
Authors: Yordanova Nikoleta , Zhelyazkova Asya 
Published: April 2024

AbstractWhen does the delegation of legislative powers to the executive endanger policy compliance? The European Union (EU) Lisbon Treaty introduced quasi-legislative tertiary legislation – delegated acts – which empowers the European Commission to amend secondary legislation. Formally, member states control delegated acts only ex post via a veto power in the Council, while they have both ex ante amendment powers and ex post veto over the alternative Commission legislation: implementing acts. However, as member states determine the choice of legislative instrument, we argue that they would consent to the Commission adopting delegated acts only on non-controversial issues. Such selection should result in their lower compliance with implementing than with delegated acts. Our analyses of member states’ transposition delays and infringement cases related to EU tertiary directives support this argument. The results suggest that the delegation of legislative powers to the executive does not increase non-compliance when the legislators have the means to moderate it ex ante.
The Alagoas Antwren Myrmotherula snowi is in imminent danger of extinction
Authors: Vilela Hermínio A. L. S. , Andrade Arthur B. , Araujo Helder F. P. , Bichinski Tony A. , Cavalcante Bárbara , Develey Pedro F. , Reisfeld Alice , Phalan Benjamin T. 
Published: April 2024

Summary
The “Critically Endangered” Alagoas Antwren Myrmotherula snowi is found only in the Atlantic Rainforest of north-east Brazil. We surveyed all sites where the species has been recorded, as well as 15 other potential sites. We summarise all observations of the species, focusing on the period from 2016 onwards, and including systematic censuses in three breeding seasons (October–March 2018/19, 2019/20, and 2020/21) at the type locality, Murici, where we also searched for nests of the species. We did not locate any individuals at sites other than Murici. The number of apparent individuals detected declined by 67% over seven years (a decline of 50% over the three years in which standardised systematic counts were made), and only six adults were observed in the most recent breeding season. The global population is now likely to be in single-digit figures. Of five nests found, four failed, through predation by snakes and opossums, and abandonment. We installed protective barriers to protect two of these nests from predators, which may have contributed to the single successful fledging. Such methods offer most hope for now of stalling the decline. Efforts to develop captive breeding methods with model species have been underway since 2019 but face many difficulties. Improving habitat protection and restoration is crucial but will only take effect in the long term.
Macro-financial imbalances and cyclical systemic risk dynamics: understanding the factors driving the financial cycle in the presence of non-linearities
Authors: O’Brien Martin , Velasco Sofia 
Published: April 2024

Abstract
This paper develops a multivariate filter based on an unobserved component model to estimate the financial cycle. Our model features: (1) a dynamic relationship between the financial cycle and key variables; (2) time-varying shock volatility for trend and cycle components. We demonstrate that our approach not only exhibits superior early warning properties for banking crises but also outperforms commonly used indicators in terms of data fit for decomposition exercises, as evidenced by the higher marginal likelihood. We document three important properties of the financial cycle. First, the sensitivity of the financial cycle to changes in real estate valuations increased during the post-90s period. Second, the sensitivity of the cycle to changes in financial conditions displays volatility and country specificities. Finally, our reduced form estimates suggest that the banking crisis of 1988 was preceded by positive contributions from the risk appetite shock, while the primary source of vulnerabilities emanated from the housing market in the run-up to the Global Financial Crisis.
Transience of (In)Formality: The Role of the Joint Initiatives in Reforming the WTO Negotiations
Authors: Peres Ana 
Published: April 2024

AbstractThis paper develops the concept of transience of (in)formality to refer to the intersection of formal and informal negotiating procedures in the WTO decision-making system. It argues that both formal and informal negotiating processes are essential for delivering negotiating outcomes in the WTO. Particularly, the article assesses how informal negotiating practices emerge within the WTO formal framework and align with it. The analysis highlights how negotiating practices (re)shape existing norms, both formal and informal, adapting the WTO to overcome challenges and meet current needs. It also disputes legal formalistic perspectives that permeate trade literature and offer limited accounts of Members' agency in the WTO. The paper uses the Joint Initiatives as a case study to illustrate the convergence between formality and informality and a possible way ahead for the WTO negotiations. By broadening the understanding of law-making, it contributes to the discussion on WTO reform. It provides alternatives that reflect the reality of WTO negotiations and underlines the institution's relevance.
Tracking the Nearfield Evolution of an Initially Shallow, Neutrally Buoyant Plane Jet Over a Sloping Bottom Boundary
Authors: Shi H. , Negretti M. E. , Chauchat J. , Blanckaert K. , Lemmin U. , Barry D. A. 
Published: April 2024

AbstractUnderstanding coastal plane jets which occur when a body of water discharges into an ocean or a lake through a channel or outlet is important, since they play a significant role in sediment, nutrient, and pollutant exchange. This study investigates the nearfield of initially shallow, neutrally buoyant plane jets, bounded by a free surface and a sloping bottom (Sloping Bottom Jet; SBJ) that issue into a laterally unconfined quiescent ambient both experimentally and numerically, and compares them with a plane jet flowing over a horizontal bottom (Horizontal Bottom Jet; HBJ). Results revealed that, different from the HBJ, the width and centerline velocity of SBJ decrease near the mouth. The SBJ width gradually increases after that as the transverse longitudinal velocity profile progressively transforms from a “top‐hat” into a Gaussian distribution. Once the Gaussian distribution is established, both jets diverge and centerline velocity decreases. Shear layers are generated on the sides of both jets with Kelvin Helmholtz‐type Coherent Structures (KHCS) developing inside. KHCS produce periodic velocity fluctuations with a Strouhal number of ∼0.079 and contribute significantly to momentum exchange and turbulent kinetic energy production. Since the thickness of the SBJ increases longitudinally, the vertical extent of KHCS also increases. When the two shear layers meet and merge at the centerline, they cause a flapping motion of the jet. This location is closer to the jet mouth for SBJs than for the HBJ. These findings demonstrate that a sloping bottom modifies the flow field from quasi‐2D for the HBJ to strongly 3D for SBJs.
Advances in the multimodal analysis of the 3D chromatin structure and gene regulation
Authors: Han Man-Hyuk , Park Jihyun , Park Minhee 
Published: April 2024

AbstractRecent studies have demonstrated that the three-dimensional conformation of the chromatin plays a crucial role in gene regulation, with aberrations potentially leading to various diseases. Advanced methodologies have revealed a link between the chromatin conformation and biological function. This review divides these methodologies into sequencing-based and imaging-based methodologies, tracing their development over time. We particularly highlight innovative techniques that facilitate the simultaneous mapping of RNAs, histone modifications, and proteins within the context of the 3D architecture of chromatin. This multimodal integration substantially improves our ability to establish a robust connection between the spatial arrangement of molecular components in the nucleus and their functional roles. Achieving a comprehensive understanding of gene regulation requires capturing diverse data modalities within individual cells, enabling the direct inference of functional relationships between these components. In this context, imaging-based technologies have emerged as an especially promising approach for gathering spatial information across multiple components in the same cell.
Gut microbiome predicts cognitive function and depressive symptoms in late life
Authors: Kolobaric A. , Andreescu C. , Jašarević E. , Hong C. H. , Roh H. W. , Cheong J. Y. , Kim Y. K. , Shin T. S. , Kang C. S. , Kwon C. O. , Yoon S. Y. , Hong S. W. , Aizenstein H. J. , Karim H. T. , Son S. J. 
Published: April 2024

AbstractDepression in older adults with cognitive impairment increases progression to dementia. Microbiota is associated with current mood and cognition, but the extent to which it predicts future symptoms is unknown. In this work, we identified microbial features that reflect current and predict future cognitive and depressive symptoms. Clinical assessments and stool samples were collected from 268 participants with varying cognitive and depressive symptoms. Seventy participants underwent 2-year follow-up. Microbial community diversity, structure, and composition were assessed using high-resolution 16 S rRNA marker gene sequencing. We implemented linear regression to characterize the relationship between microbiome composition, current cognitive impairment, and depressive symptoms. We leveraged elastic net regression to discover features that reflect current or future cognitive function and depressive symptoms. Greater microbial community diversity associated with lower current cognition in the whole sample, and greater depression in participants not on antidepressants. Poor current cognitive function associated with lower relative abundance of Bifidobacterium, while greater GABA degradation associated with greater current depression severity. Future cognitive decline associated with lower cognitive function, lower relative abundance of Intestinibacter, lower glutamate degradation, and higher baseline histamine synthesis. Future increase in depressive symptoms associated with higher baseline depression and anxiety, lower cognitive function, diabetes, lower relative abundance of Bacteroidota, and lower glutamate degradation. Our results suggest cognitive dysfunction and depression are unique states with an overall biological effect detectable through gut microbiota. The microbiome may present a noninvasive readout and prognostic tool for cognitive and psychiatric states.
Reduced intensity versus myeloablative conditioning for MDS: long-term results of an EBMT phase III study (RICMAC)
Authors: Niederwieser Christian , Iacobelli Simona , Franke Georg-Nikolaus , Koster Linda , van Os Marleen , Platzbecker Uwe , Hübel Kai , Scheid Christof , Müller Lutz Peter , Stelljes Matthias , Morozova Elena , Passweg Jakob , Onida Francesco , Dreger Peter , Saccardi Riccardo , Ladetto Marco , Salmenniemi Urpu , Bethge Wolfgang , Poiré Xavier , Kobbe Guido , McLornan Donal P. , Robin Marie , Kröger Nicolaus 
Published: April 2024

AbstractShort-term outcome of myeloablative (MAC) and reduced intensity (RIC) conditioning in the prospective randomized international EBMT RICMAC study in patients with myelodyplastic syndrome (MDS) was comparable but longer follow up is lacking. Patients with MDS aged 18–65 years were randomized to receive MAC (N = 64) with busulfan/cyclophosphamide or RIC (n = 65) with busulfan/fludarabine followed by stem cell transplantation -(HCT) from HLA matched or mismatched donor. After a median follow-up of 6.2 (0.4–12.5) years, 10-year OS and RFS were 54.0% and 43.9% for RIC and 44.4% and 44.2% for MAC (p = 0.15 and p = 0.78), respectively. Since the first report, 6 patients died on NRM, 4 after RIC, and 2 after MAC. Similarly, 8 patients relapsed (4 in each arm), increasing the number of relapsed patients to 28. The second HCT was performed in 18 pts, 8 in the MAC, and 10 in the RIC arm. In a multivariate analysis, ECOG status and chemotherapy prior to HCT were independent risk factors for OS and RFS, ECOG and low cytogenetic risk for NRM and chemotherapy prior to HCT for RI. Patients with low cytogenetic risk had better OS [p = 0.002], RFS [p = 0.02], and NRM (p = 0.015) after RIC as compared to MAC.
The first genetically confirmed cohort of Facioscapulohumeral Muscular Dystrophy from Northern India
Authors: Vishnu Venugopalan Y. , Lemmers Richard J. L. F. , Reyaz Alisha , Mishra Rinkle , Ahmad Tanveer , van der Vliet Patrick J. , Kretkiewicz Marcelina M. , Macken William L. , Efthymiou Stephanie , Dominik Natalia , Morrow Jasper M. , Bhatia Rohit , Wilson Lindsay A. , Houlden Henry , Hanna Michael G. , Bugiardini Enrico , van der Maarel Silvère M. , Srivastava M. V. Padma 
Published: April 2024

AbstractFacioscapulohumeral muscular dystrophy (FSHD) is the third most common form of hereditary myopathy. Sixty per cent of the world’s population lives in Asia, so a significant percentage of the world’s FSHD participants is expected to live there. To date, most FSHD studies have involved individuals of European descent, yet small-scale studies of East-Asian populations suggest that the likelihood of developing FSHD may vary. Here, we present the first genetically confirmed FSHD cohort of Indian ancestry, which suggests a pathogenic FSHD1 allele size distribution intermediate between European and North-East Asian populations and more asymptomatic carriers of 4 unit and 5 unit FSHD1 alleles than observed in European populations. Our data provides important evidence of differences relevant to clinical diagnostics and underscores the need for global FSHD participation in research and trial-ready Indian FSHD cohorts.
Age related cerebrospinal fluid flow dynamics in the subarachnoid space of the optic nerve in patients with normal tension glaucoma, measured by diffusion weighted MRI
Authors: Berberat Jatta , Pircher Achmed , Remonda Luca , Killer Hanspeter E. 
Published: April 2024

Abstract
Background/objectives
We aimed to measure cerebrospinal fluid (CSF) flow rates in the subarachnoid space (SAS) of the optic nerve (ON) by applying non-invasive diffusion-weighted MRI in patients with normal tension glaucoma (NTG) compared to age-matched controls.

Subjects/methods
In this prospective study, an analysis of diffusion-weighted images of 26 patients with NTG (49ONs) and age-matched volunteers (52ONs) was conducted. Subjects were classified into 4 groups: group I (50–59 y., n = 12 eyes), group II (60–69 y., n = 16 eyes), group III (70–79 y., n = 18 eyes) and group IV ( > 80 y., n = 6 eyes) for NTGs and healthy volunteers, respectively. The flow-range ratio (FRR) between the frontal lobe SAS and the SAS of the ON was calculated for each age category group and then compared between age-categories as well as between NTGs and controls.

Results
The mean FRR for age groups were (I) 0.54 ± 0.06 and 0.62 ± 0.03 (p < 0.05), (II) 0.56 ± 0.08 and 0.63 ± 0.03 (p < 0.05), (III) 0.54 ± 0.06 and 0.62 ± 0.02 (p < 0.001) as well as (IV) 0.61 ± 0.03 and 0.61 ± 0.04, for NTGs and controls, respectively. Using pooled data, the difference between the FRR in NTGs and controls was statistically significant (p < 0.0001). There were no statistically significant differences within the age categories of the control group. When comparing the FRR of NTGs by age categories, no statistically significant difference was found between the subgroups.

Conclusions
FRR was significantly reduced in NTGs compared to age-matched controls without any significant differences within the age groups themselves. Given the physiological importance of CSF for the integrity of neurons, axons and glial cells, reduced CSF flow dynamics might be part of the underlying neurodegenerative process of NTG.
Lysosomal genes contribute to Parkinson’s disease near agriculture with high intensity pesticide use
Authors: Ngo Kathie J. , Paul Kimberly C. , Wong Darice , Kusters Cynthia D. J. , Bronstein Jeff M. , Ritz Beate , Fogel Brent L. 
Published: April 2024

AbstractParkinson’s disease (PD), the second most common neurodegenerative disorder, develops sporadically, likely through a combination of polygenic and environmental factors. Previous studies associate pesticide exposure and genes involved in lysosomal function with PD risk. We evaluated the frequency of variants in lysosomal function genes among patients from the Parkinson’s, Environment, and Genes (PEG) study with ambient pesticide exposure from agricultural sources. 757 PD patients, primarily of White European/non-Hispanic ancestry (75%), were screened for variants in 85 genes using a custom amplicon panel. Variant enrichment was calculated against the Genome Aggregation Database (gnomAD). Enriched exonic variants were prioritized by exposure to a cluster of pesticides used on cotton and severity of disease progression in a subset of 386 patients subdivided by race/ethnicity. Gene enrichment analysis identified 36 variants in 26 genes in PEG PD patients. Twelve of the identified genes (12/26, 46%) had multiple enriched variants and/or a single enriched variant present in multiple individuals, representing 61% (22/36) of the observed variation in the cohort. The majority of enriched variants (26/36, 72%) were found in genes contributing to lysosomal function, particularly autophagy, and were bioinformatically deemed functionally deleterious (31/36, 86%). We conclude that, in this study, variants in genes associated with lysosomal function, notably autophagy, were enriched in PD patients exposed to agricultural pesticides suggesting that altered lysosomal function may generate an underlying susceptibility for developing PD with pesticide exposure. Further study of gene-environment interactions targeting lysosomal function may improve understanding of PD risk in individuals exposed to pesticides.
Large language models for preventing medication direction errors in online pharmacies
Authors: Pais Cristobal , Liu Jianfeng , Voigt Robert , Gupta Vin , Wade Elizabeth , Bayati Mohsen 
Published: April 2024

AbstractErrors in pharmacy medication directions, such as incorrect instructions for dosage or frequency, can increase patient safety risk substantially by raising the chances of adverse drug events. This study explores how integrating domain knowledge with large language models (LLMs)—capable of sophisticated text interpretation and generation—can reduce these errors. We introduce MEDIC (medication direction copilot), a system that emulates the reasoning of pharmacists by prioritizing precise communication of core clinical components of a prescription, such as dosage and frequency. It fine-tunes a first-generation LLM using 1,000 expert-annotated and augmented directions from Amazon Pharmacy to extract the core components and assembles them into complete directions using pharmacy logic and safety guardrails. We compared MEDIC against two LLM-based benchmarks: one leveraging 1.5 million medication directions and the other using state-of-the-art LLMs. On 1,200 expert-reviewed prescriptions, the two benchmarks respectively recorded 1.51 (confidence interval (CI) 1.03, 2.31) and 4.38 (CI 3.13, 6.64) times more near-miss events—errors caught and corrected before reaching the patient—than MEDIC. Additionally, we tested MEDIC by deploying within the production system of an online pharmacy, and during this experimental period, it reduced near-miss events by 33% (CI 26%, 40%). This study shows that LLMs, with domain expertise and safeguards, improve the accuracy and efficiency of pharmacy operations.
Surgery is associated with better long-term outcomes than pharmacological treatment for obesity: a systematic review and meta-analysis
Authors: Pipek Leonardo Zumerkorn , Moraes Walter Augusto Fabio , Nobetani Rodrigo Massato , Cortez Vitor Santos , Condi Alberto Santos , Taba João Victor , Nascimento Rafaela Farias Vidigal , Suzuki Milena Oliveira , do Nascimento Fernanda Sayuri , de Mattos Vitoria Carneiro , Iuamoto Leandro Ryuchi , Hsing Wu Tu , Carneiro-D’Albuquerque Luiz Augusto , Meyer Alberto , Andraus Wellington 
Published: April 2024

AbstractObesity is a highly prevalent disease with numerous complications. Both intensive medical treatment with the use of pharmacological drugs and bariatric surgery are current options. The objective of this meta-analysis was to compare, in the long-term, intensive medical treatment and surgery based on twelve parameters related to weight loss, cardiovascular and endocrine changes. A review of the literature was conducted in accordance with the PRISMA guidelines (PROSPERO: CRD42021265637). The literature screening was done from inception to October 2023 through PubMed, EMBASE and Web of Science databases. We included randomized clinical trials that had separate groups for medical treatment and bariatric surgery as an intervention for obesity. The risk of bias was assessed through RoB2. A meta-analysis was performed with measures of heterogeneity and publication bias. Subgroup analysis for each surgery type was performed. Data is presented as forest-plots. Reviewers independently identified 6719 articles and 6 papers with a total 427 patients were included. All studies were randomized controlled trials, three had a follow up of 5 years and two had a follow up of 10 years. Both groups demonstrated statistical significance for most parameters studied. Surgery was superior for weight loss (− 22.05 kg [− 28.86; − 15.23), total cholesterol (− 0.88 [− 1.59; − 0.17]), triglycerides (− 0.70 [− 0.82; − 0.59]), HDL (0.12 [0.02; 0.23]), systolic pressure (− 4.49 [− 7.65; − 1.33]), diastolic pressure (− 2.28 [− 4.25; − 0.31]), Hb glycated (− 0.97 [− 1.31; − 0.62]), HOMA IR (− 2.94; [− 3.52; − 2.35]) and cardiovascular risk (− 0.08; [− 0.10; − 0.05]). Patient in the surgical treatment group had better long term outcomes when compared to the non-surgical group for most clinical parameters.