bluuebunny/crossref_metadata_2025_split huggingface dataset:
Interbasin river mapping between Californian and Turkish rivers for climate change assessment
Authors: Dogan Mustafa Sahin 
Published: May 2024

ABSTRACT

A climate change assessment for streamflow availability of the selected rivers in Turkey is presented. Using an Index Basin Mapping (IBM) approach, climate change information is transferred across hydrologically similar rivers. This approach maps rivers of interest without downscaled climate information to index rivers where climate projections are available. Then, monthly perturbation ratios of index rivers, conveying projected climatic changes, are applied to the mapped rivers. Climate change effects on monthly streamflow availability and timing in eight selected rivers are evaluated under 20 scenarios produced from 10 General Circulation Models (GCMs) under medium and high emission cases. Results show that winter streamflow availability will increase due to more precipitation falling as rainfall rather than snowfall. Spring and summer streamflow availability will decrease due to reduced snowmelt runoff. Monthly streamflow variability will increase in all evaluated rivers. Out of eight selected rivers, the Çoruh, Yeşilırmak and Zamantı Rivers will be the most affected by climatic changes, with 14.6, 4.1, and 5.6% reductions in overall water availability under the high emission ensemble scenario. Overall water availability is projected increase in the Ceyhan and Göksu Rivers with climate change. Increased monthly streamflow variability can complicate water management in the region.
Avapritinib Carries the Risk of Drug Interaction via Inhibition of UDP-Glucuronyltransferase (UGT) 1A1
Authors: Lv Xin , Wang Zhen , Wang Zhe , Yin Hang , Xia Yangliu , Jiang Lili , Liu Yong 
Published: May 2024

Background:
Avapritinib is the only drug for adult patients with PDGFRA exon 18 mutated unresectable or metastatic gastrointestinal stromal tumor (GIST). Although avapritinib has been approved by the FDA for four years, little is known about the risk of drug-drug interac-tions (DDIs) via UDP-glucuronyltransferases (UGTs) inhibition.

Objective:
The aim of the present study was to systematically evaluate the inhibitory effects of avapritinib against UGTs and to quantitatively estimate its potential DDIs risk in vivo.

Methods:
Recombinant human UGTs were employed to catalyze the glucuronidation of sub-strates in a range of concentrations of avapritinib. The kinetics analysis was performed to evaluate the inhibition types of avapritinib against UGTs. The quantitative prediction of DDIs was done using in vitro-in vivo extrapolation (IVIVE).

Results:
Avapritinib had a potent competitive inhibitory effect on UGT1A1. Quantitative predic-tion results showed that avapritinib administered at clinical doses might result in a 14.85% in-crease in area under the curve (AUC) of drugs primarily cleared by UGT1A1. Moreover, the Rgut value was calculated to be 18.44.

Conclusion:
Avapritinib has the potential to cause intestinal DDIs via the inhibition of UGT1A1. Additional attention should be paid when avapritinib is coadministered with UGT1A1 substrates.
GLP-1/GIP Agonist as an Intriguing and Ultimate Remedy for Combating
Alzheimer’s Disease through its Supporting DPP4 Inhibitors: A Review
Authors: Abubakar Mohammad , Nama Lokesh , Ansari Mohammad Arif , Ansari Mohammad Mazharuddin , Bhardwaj Shivani , Daksh Rajni , Syamala Katta Leela Venkata , Jamadade Mohini Santosh , Chhabra Vishal , Kumar Dileep , Kumar Nitesh 
Published: May 2024

Background:
Alzheimer's disease (AD) is a widespread neurological illness in the
elderly, which impacted about 50 million people globally in 2020. Type 2 diabetes has been identified
as a risk factor. Insulin and incretins are substances that have various impacts on neurodegenerative
processes. Preclinical research has shown that GLP-1 receptor agonists decrease neuroinflammation,
tau phosphorylation, amyloid deposition, synaptic function, and memory formation.
Phase 2 and 3 studies are now occurring in Alzheimer’s disease populations. In this article, we present
a detailed assessment of the therapeutic potential of GLP-1 analogues and DPP4 inhibitors in
Alzheimer’s disease.

Aim:
This study aimed to gain insight into how GLP-1 analogues and associated antagonists of
DPP4 safeguard against AD.

Methods:
This study uses terms from search engines, such as Scopus, PubMed, and Google Scholar,
to explore the role, function, and treatment options of the GLP-1 analogue for AD.

Results:
The review suggested that GLP-1 analogues may be useful for treating AD because they
have been linked to anti-inflammatory, neurotrophic, and neuroprotective characteristics. Throughout
this review, we discuss the underlying causes of AD and how GLP signaling functions.

Conclusion:
With a focus on AD, the molecular and pharmacological effects of a few GLP-1/GIP
analogs, both synthetic and natural, as well as DPP4 inhibitors, have been mentioned, which are in
the preclinical and clinical studies. This has been demonstrated to improve cognitive function in
Alzheimer's patients.
Recent Patents for Machine Vision Inspection in the Machine Tool Sector
Authors: Li Zhaolong , zhao kai 
Published: May 2024

Abstract::
In the current modern manufacturing industry, the demand for product quality control is
increasing, as is the need for automation. However, the manual inspection may need to be noticed or
undetectable in the complex production process. To solve this phenomenon, machine vision-based
inspection of machine tools and their product features has become one of the key technologies in
intelligent manufacturing. The basic principle of machine tool machine vision inspection is to
transmit the object to be inspected to the computer through efficient image acquisition. Then, image
processing or deep learning algorithms classify, locate, segment, and process the features of the
thing. Finally, the computer makes the judgment of whether it is qualified. According to recent numerical
analysis data, compared with traditional methods, machine tool machine vision inspection
can improve the inspection efficiency by 30%, and the accuracy has reached 98%, much higher than
manual inspection accuracy. This study provides an in-depth review of representative patents and
machine tool vision inspectionpatents , and it comprehensively summarizes the research results from
various dimensions in recent year. In the past five years, the average annual growth rate of machine
tool vision inspection technology has reached 15%, showing the rapid development momentum of
this field. The research content mainly focuses on designing vision detection structures, algorithm
optimization designs, and personalized solutions for object differences.
Antidepressant Effect of Vincamine, Melatonin and their
Combination in Experimental Rat Models of Depression
Authors: Bee Rizwana , Ahmad Mohammad , Verma Shashi , Khan Mohammad Irfan , Budruddeen  , Akhtar Juber , Patel Mayank 
Published: May 2024

Background:
Depression, a form of mood illness, is characterized by a lack of
or diminished social life, melancholy, and symptoms linked to an uplifted or depressed
mood. Vincamine and Melatonin combination may prove beneficial for treating depression
because vincamine and melatonin have already been reported in the treatment of dementia.
Dementia is a CNS disorder which is connected to the level of neurotransmitters at the
synaptic cleft, which is similar to depression that is why it might be effective in the treatment
of depression.

Aim:
The aim of this research is to conduct an experimental study on the antidepressant
activity of Vincamine alone and along with Melatonin and comparison with standard antidepressant
drugs.

Method:
In this study, all animals are trained for the experiment, and then animals are divided
into groups according to the treatment protocol. Animals were placed for the rest for
1 week. Vincamine and melatonin were administered to the treated groups on days 8 and
21 for the behavioral analysis using different kinds of models like elevated plus maze,
forced swim test, open field test and sucrose preference test. Animals were sacrificed at
day 22 for the estimation of biochemical (SOD) and neurotransmitters (Serotonin, Norepinephrine
and Dopamine).

Results:
After extensive investigation, it has been established that Vincamine, alone and in
combination with Melatonin, is beneficial in treating depression. Positive results are obtained.
The group treated with Vincamine taken per oral route ((10 mg/kg), Melatonin (10
mg/kg), Vincamine + Melatonin (10 mg/kg + 10 mg/kg) and std (10 mg/kg) treatment
showed significant result which are followed as for all groups (a) p < 0.0001 vs. NC; (b) p
< 0.0001 vs. disease control; (c) p < 0.05 vs. Std (10 mg/kg); (d) p < 0.001V vs. M (10
mg/kg); (e) p < 0.0090 vs. V+M (10 mg/kg+10 mg/kg). It was demonstrated by a number
of behavioral (elevated plus maze, forced swim test, open field test, and sucrose preference
test) and biochemical parameters (estimation of neurotransmitters such as serotonin, norepinephrine,
and dopamine). Vincamine alone and in combination with Melatonin demonstrated
positive results (p < 0.0001) in the evaluation of the SOD antioxidant defence system.
Also, it significantly attenuated the alteration in locomotor activity, oxidative stress
and neurotransmitters in rat brain.

Conclusion:
It has been concluded that vincamine alone and along with melatonin is effective
for the treatment of depression on the basis of behavioural and biochemical parameters.
That’s why it might be useful for the future prospect.
Production and Chemical Characterization of Silage from Saccharine Sorghum Fertirrigated with Sugarcane Vinasse
Authors: Correia Arlindo Fabrício , Godoy Antonio Cesar , Scardua Marcos Paiva , Oxford Jarred H. , de Oliveira Paulo Sérgio Rabello , Fukumoto Nelson , Feiden Armin 
Published: May 2024

Background:
Distillery vinasse is one of the promising bio-fertilizers, as it contains significant amounts of essential chemical elements, allied with sorghum that is widely used in the diet of ruminant animals and has been considered as an alternative to the production of other cereals or forages. This study aimed to evaluate saccharin sorghum silage from fertilization with vinasse.

Methods:
The research was conducted using the BRS-511, CR-1339, and CR-1342 geno-types. The silage was held for 170 days after sowing, with experimental design in blocks with triple factorial (genotypes x fertilization x inoculation) totaling 54 installments. At 95 days, the silos were opened for sample collection and analysis bromatological analysis.

Results:
The results indicate the primary source of variation was genotype, characterizing them with different potentials in productivity and better results for BRS-511, CR-1339, and CR-1342. The bromatological results indicate good quality for CR-1339 and CR-1342 hybrids, however, better digestability for BRS-511. There was no observable difference between the factors of fertilization. The inoculation additive assists in the reduction of lignin appears to be high. PCA analysis showed differences between cultivars (BRS-511, CR-1339, and CR-1342) and fertili-zation. However, the PCAs showed the genotypes show similar results with conventional ferti-lization and sugarcane vinasse.

Conclusion:
The study reflected the possibility of producing sweet sorghum silage with soil sugarcane vinasse fertilization as fertilizer.
Cancer Narrative with a Difference: Elaine Feeney΄s ‘As You Were’
Authors: Feldman-Kołodziejuk Ewelina 
Published: May 2024

Elaine Feeney΄s novel As You Were offers the story of a terminal cancer patient who forsakes any medical treatment. Narrating the final moments of her protagonist’s life, the author breaks with the traditional cancer novel formula in which a bellicose stance is prescriptive. Instead, the heroine’s stay at a hospital ward with other female patients constitutes Feeney΄s point of departure for writing a state-of-the-nation novel. The article discusses how the merging of different literary traditions, such as cancer narrative, literature of witness, or experimental fiction, allows the author to paint a poignant picture of Irish society, in which women, whose rights were historically curbed, empower each other through telling their life stories as well as reclaiming the life tales of their lost sisters. The analysis focuses on metaphors and narrative strategies that customarily underpin cancer stories and which can be identified in the novel. Secondly, the subversion of the cancer narrative is taken under scrutiny to demonstrate the experimental character of Feeney΄s novel. Subsequently, the ethical dimension of storytelling is given critical attention and the work’s status as a state-of-the-nation novel is elaborated on.
Existentialist Motifs of Alienation and Death in McCarthy’s ‘Border Trilogy’
Authors: Kachur Iryna 
Published: May 2024

The article closely reads Cormac McCarthy’s Border Trilogy in light of the existentialist motifs of alienation and death. The aim of the study is to analyse the literary representation of these motifs in the trilogy. The applied methodology involves close reading, which facilitates identifying the motifs of death and alienation in the novels; character analysis, focused on exploring the main characters’ experiences of death and alienation; and comparative analysis, which is used to compare the representation of the existentialist motifs in the novels. The study reveals that in The Border Trilogy, the existentialist motif of alienation manifests itself through the desire of the main characters to free themselves from social conventions and to mend the wrongness of the world they live in. This motif takes forms of madness, alienation from other characters, and isolation from society. The protagonists, looking for their place in the world, face hardships, encounter resistance, and therefore constantly feel estrangement. In the novels, the existentialist motif of death serves for a better understanding of human nature and is one of the driving forces of the protagonists’ existence. This motif manifests itself through blood and bones, dreams, natural and violent deaths, the extermination of nature, and the disappearance of established traditions. Symbolising the end of existence, death prompts the main characters to search for the purpose of their lives and strive for authenticity.
The Portrayal of the Polish-Lithuanian Peasantry in the Memoir Accounts of British Travelers (1764-1795)
Authors: Nieroda Łukasz 
Published: May 2024

The article analyzes the descriptions of Polish-Lithuanian peasants found in travel literature penned by British visitors to Poland during the reign of Stanisław August Poniatowski. It aims to present the literary image of peasantry and comment on the Britons’ attitude towards the problems they faced. The authors whose works are analyzed are William Coxe (historian and tutor), John Lind (associate of a Polish king), Nathaniel Wraxall (traveler and ex-merchant), James Harris (a future diplomat), Joseph Marshall (a mysterious figure, probably a merchant) and John Williams. Villagers are generally described as miserable human beings struggling with poverty, cruelly exploited by their lords in a condition resembling slavery. The authors’ attitude is sympathetic to the difficulties of peasant lives. Britons appreciated attempts to extricate them from their plight in the belief that emancipation was ethically desirable and would render their work more productive.
Pengaruh Modifikasi Media Tanam Hidroton dan Zat Pengatur Tumbuh terhadap Produktivitas Tanaman Pakcoy (Brassica Rapa L.) Secara Hidroponik Sistem Wick
Authors: Nabila Nila Anjali , Purbajanti Endang Dwi , Budiyanto Susilo 
Published: May 2024

The quality of pakcoy plants in hydroponic cultivation is influenced by the planting medium and the growth regulators given to the leaves of pakcoy plants to get good plant results. The aim of the research was to examine the effect of modifying hydroton planting media by providing plant growth substances concentrations on plant growth and production. This research uses 3 x 4 Factorial Complately Random Design with 3 replications. The first factor for modification of hydroton planting media includes hydroton (M0), hydroton+cocopeat (M1), hydroton+charcoal husk (M2), the second factor PGR concentration includes o ml/liter (H0), 2 ml/liter (H1), 4 ml /liter (H2), 6ml/liter (H3). Data were analyzed using Range Analysis and tested further using DMRT (Duncan Multiple Range Test) at the 5% level. The research results showed that there was an interaction effect between modified hydroton planting media and PGR concentration on leaf width and leaf area parameters. The hydroton planting media modification treatment had a significant effect on all parameters except root length. Keywords : cocopeat, hidroton, modification, pakcoy
Aplikasi Formulasi Bahan Pembenah Tanah terhadap Beberapa Sifat Kimia Tanah Berpasir dan Produksi Tanaman Padi
Authors: Aprilia Intan Bella , Sasongko Purnomo Edi , Siswanto Siswanto 
Published: May 2024

Sandy soil is part of the soil fraction with low nutrient content, organic matter, and cation exchange capacity. This is due to the leaching process so that nutrients are easily lost. The research aimed to improve the chemical characteristics of sandy soil and rice crop production due to the application of humic acid and silica. This research used of Completely Randomized Design method using soil amendment materials, namely humic acid (A) at the of 60 kg/ha and silica (S) at the of 5 tons/ha consisting of 6 combinations of comparisons repeated 4 times. Variables of analysis parameters include pH, cation exchange capacity, organic matter, N-NH4+, N-NO3- and rice crop production. The data obtained were analyzed by analysis of variance (ANOVA). If the results showed a significant effect, it was continued with the Honestly Significant Difference (HSD) test at the 5% level. The results showed that the application of soil amendment in the from humic acid and silica with various treatments on sandy soil was only able to improve CEC by 3,18% and Organic-C by 0,08%. In contrast soil pH and N-available didn`t give significant results in improving soil chemical properties and rice crop production. It`s recommended to conduct further research on the dose used in soil amendments so that it can effect nitrogen parameters and rice crop production in sandy soil. Keywords: humic acid, silica, sandy soil
Short Blizzard Episode in the Northeastern Part of Romania, in the Second Decade of November 2023
Authors: Timofte Adrian , Bostan Diana-Corina , Apetroaie Cosmina 
Published: May 2024

Abstract
Severe weather phenomena are those meteorological phenomena that can temporarily become dangerous for the population, by threatening its safety or can cause material damage in a certain area. In order for the authorities and the population to be notified in time, meteorological warnings are issued. Therefore, issuing a warning will be taken into account according to the degree of severity of the forecasted meteorological phenomenon and will take into account its extent, how it will evolve and the degree of vulnerability of the regions to be affected. For this purpose, warning thresholds have been established for certain meteorological phenomena that can become dangerous, and based on this, color codes have been established, which gradually show the dangerousness of the phenomena that are about to occur. In the cold season, the blizzard is part of the category of dangerous meteorological phenomena, even more so when they are early or late, in the months of November or April. If the late ones are more frequent, (in the last 10 years there were 2 blizzard events, in 2017 and 2023), the early ones have an even lower frequency, and sometimes it can be a derivative of this phenomenon, because they are not met all the blizzard conditions. This study analyzes a phenomenon that took place in the second decade of November 2023 in the region of Moldova and which was associated with the blizzard phenomenon.
The Myths of Romantic Love and Violence in Courtship
Authors: Lozano Vanessa Vallejo , Aranda Gabriela Isabel Pérez , Estrada-Carmona Sinuhé , Garcia-Reyes Liliana , Sierra Miguel Àngel Tus 
Published: May 2024

Objective: The objective is to analyze the relationship between the myths of romantic love and intimate partner violence, to identify the predictive factors.

Theoretical Framework: Partner violence has its beginnings in dating; through obvious or invisible behaviors due to their normalization. In Mexico, 70.1% of women aged 15 years and older have experienced at least one situation of violence throughout their lives (INEGI, 2022). On the other hand, the myths of romantic love are a set of socially supported beliefs with sexist ideals that can be a direct source of information to know if it is related to violence in the couple.

Method: The proposed research is quantitative, non-experimental and correlational. The instruments used were: Boyfriend Violence Questionnaire by Rodríguez-Franco et al., (2010) and the Romantic Love Myths Scale by Bonilla and Rivas (2020). 200 people (65 men and 135 women) adolescents in the age range of 16 to 23 years participated.

Results and Discussion: Significant relationships (p<.05) were found between the myths of distorted love and dating violence, since actions that cause harm to the subject are minimized. Distorted myths are related to humiliation, sexual violence, physical coercion, gender violence, emotional and instrumental punishment in the relationship.

Implications of the research: The findings contribute to the understanding of emotional health in couple relationships, as well as the psychosocial dynamics between beliefs and practices of violence in relationships.

Originality/Value: This study contributes to the understanding of violence and the role of myths of romantic love in couple relationships in the context of southeastern Mexico.
فهم الأفكار لدى الأطفال من أعمار (3 – 7) سنوات (دراسة مستعرضة)
Authors: حسن محمد الحيدري سربه محمد 
Published: May 2024

تهدف الدراسة الحالية التعرف على العمر الذي يفهم فيه ما يمثله رسم الفكرة (فقاعة فكرة) من حيث الشكل والمضمون بالإضافة هناك فروق في الفهم تبعا لمتغير العمر والجنس 0
يتكون مجتمع البحث الحالي من الاطفال بأعمار(7،6،5،4،3) سنوات والبالغ اعدادهم (100) طفل بواقع (20) طفلا لكل فئة عمرية مناصفة بين الذكور والاناث في دور الحضانة ورياض الاطفال والمدارس الابتدائية في مدينة تكريت ، اختار الباحث(5) حضانات بصورة عشوائية تمثل (3) سنوات اما رياض الاطفال فكانت للفئة العمرية (5،4) سنوات، وكذلك اختار الباحث (5) سنوات مدارس ابتدائية بصورة عشوائية للفئة العمرية (7،6) سنوات ،وقد توصلت الدراسة الى النتائج التالية :أ- العمر الذي يفهم فيه ما يمثله رسم الفكرة(فقاعة فكرة)من حيث الشكل :اظهرت النتائج ان الاطفال بعم (5،3) سنوات لم يقدموا ايه اجابة صحيحة عن ما يعنيه رسم الفكرة (فقاعة الفكرة) 0ب- العمر الذي يفهم فيه ما يمثله رسم الفكرة (فقاعة الفكرة) من حيث المضمون ، اظهرت النتائج ان (8) اطفال من عمر (3) سنوات قد اجابوا اجابة صحيحة بنسبة (40%) اما الاطفال من ذوي الاعمار (4) سنوات فقد اشار(16) طفلا منهم وبنسبة (80%) الى ما تفكر فيه الشخصية ، وقد قدم اطفال بعمر (7،6،5) سنوات كانت اجابات صحيحة وبنسبة (100%) 0