bluuebunny/crossref_metadata_2025_split huggingface dataset:
In Utero Exposure to Maternal SARS-CoV-2 Infection Is Associated With Higher Left Ventricular Mass in Toddlers
Authors: Ockene Mollie W , Balaguru Duraisamy , Ma Ingrid L , Russo Samuel C , Arpante Allison K , Clifford Alexandra , Jasset Olyvia J , Kim Joon H , Toribio Mabel , Stanley Takara L , Shook Lydia L , Edlow Andrea G , Fourman Lindsay T 
Published: May 2024

Abstract
The intrauterine environment plays a critical role in shaping chronic disease risk over the life course. We prospectively evaluated cardiometabolic outcomes in toddlers born to mothers with versus without prenatal severe acute respiratory syndrome coronavirus 2 infection. Children with in utero severe acute respiratory syndrome coronavirus 2 exposure had higher left ventricular mass in association with altered maternal immunologic indices.
Community notes increase trust in fact-checking on social media
Authors: Drolsbach Chiara Patricia , Solovev Kirill , Pröllochs Nicolas 
Published: May 2024

AbstractCommunity-based fact-checking is a promising approach to fact-check social media content at scale. However, an understanding of whether users trust community fact-checks is missing. Here, we presented n=1,810 Americans with 36 misleading and nonmisleading social media posts and assessed their trust in different types of fact-checking interventions. Participants were randomly assigned to treatments where misleading content was either accompanied by simple (i.e. context-free) misinformation flags in different formats (expert flags or community flags), or by textual “community notes” explaining why the fact-checked post was misleading. Across both sides of the political spectrum, community notes were perceived as significantly more trustworthy than simple misinformation flags. Our results further suggest that the higher trustworthiness primarily stemmed from the context provided in community notes (i.e. fact-checking explanations) rather than generally higher trust towards community fact-checkers. Community notes also improved the identification of misleading posts. In sum, our work implies that context matters in fact-checking and that community notes might be an effective approach to mitigate trust issues with simple misinformation flags.
A review of medicinal plants used for the restoration of reproductive functionality following cimetidine-induced reproductive toxicity
Authors: Ikuomola Emmanuel Orire , Oka Victor , Aja Patrick Maduabuchi , Felix Ugwu Nnaemeka , Umar Uthman Shehu , Adeniyi Adekunle Ismahil , Abodunrin Victor Kehinde , Etukudo Ekom Monday , Okechukwu Paul-Chima Ugwu 
Published: May 2024

Abstract

Objectives
This review investigates cimetidine’s impact on testicular function, emphasizing histopathological changes, and impaired spermatogenesis resulting in reduced sperm count. Cimetidine disrupts the hormonal balance in both genders. The study explores the potential of medicinal plants (Curcuma longa, Nigella sativa, Tetracarpidium conophorium, Ginger Rhizome, and Kaempferia parviflora rhizome extract) to counter cimetidine-induced toxicity.

Methods
A systematic review within the Population, Intervention, Comparison, Outcome, and Study design (PICOS) framework and adherence to Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) 2020 standards, which outline comprehensiveness, accuracy, and reporting guidelines for systematic reviews and meta-analyses, identified relevant literature through electronic databases.

Findings
Medicinal plants exhibit diverse mechanisms, indicating the potential to restore reproductive functionality and mitigate cimetidine-induced toxicity. They serve as adjunctive treatments for managing reproductive impairments caused by cimetidine.

Conclusions
This review provides concise insights into the potential of medicinal plants, notably C. longa, Nigella sativa, Tetracarpidium conophorium, Ginger Rhizome, and Kaempferia parviflora rhizome extract, as interventions against cimetidine-induced reproductive toxicity. These findings propose alternative strategies for addressing reproductive impairments linked to cimetidine.
Anti-apoptotic and anti-inflammatory protective mechanisms of Gmelina arborea stem bark extract on ischemic reperfusion injury in albino Wistar rats
Authors: Bukke Sarad Pawar Naik , Gali Avinash Kumar , Igbinoba Sharon Iyobor , Venkateswarlu Garla , Bello Hussaini , Goruntla Narayana , Onohuean Hope 
Published: May 2024

Abstract

Ethnopharmacological relevance
Gemlina arborea Roxb. ex.’s entire plant is utilized in medicine to treat several diseases.

Objective and design
Cerebral infarction occurs through multiple mechanisms, and herbs are natural multi-component with numerous protective mechanisms. This research investigates the neuroprotective effect of Gemlina arborea stem bark extract in preventing cerebral infarction.

Methodology
Male albino Wistar rats were inducted with ischemic injury using the bilateral common carotid artery occlusion method. Neurological effects were examined by motor defects, locomotor activity, and forced swim test, while biochemical activities of the brain oxidative stress biomarkers studied include; (lipid peroxidation, superoxide dismutase, catalase levels, glutathione levels, total calcium levels, and sodium-potassium-ATPase) and histopathological examination. Western blotting analysis was used to study the anti-apoptotic and anti-inflammatory mechanisms.

Results
The elevated oxidative stress biomarkers in the treated group showed extract-inhibited cerebral infarction. Histological examination shows inhibited neutrophil migration and cell damage. The western blot assay depicts reductions in the inflammatory indicators (p38 MAPK, TNF- α) and attenuation of apoptotic mediators (Bcl2/Bax ratio), down-regulation of caspase-3 expression, and a significantly raised anti-inflammatory mediators (IL-10 and actin) in a dose-dependent manner, suggested potential mechanisms by which the extract prevented ischemic reperfusion injury.

Conclusion
Overall, the estimation of inflammatory and apoptotic mediators revealed the involvement of the anti-inflammatory mechanisms of Gmelina arborea stem bark extract in preventing cerebral infarction.
Functional Connectivity-Based Searchlight Multivariate Pattern Analysis for Discriminating Schizophrenia Patients and Predicting Clinical Variables
Authors: Chen Yayuan , Wang Sijia , Zhang Xi , Yang Qingqing , Hua Minghui , Li Yifan , Qin Wen , Liu Feng , Liang Meng 
Published: May 2024

Abstract

Background
Schizophrenia, a multifaceted psychiatric disorder characterized by functional dysconnectivity, poses significant challenges in clinical practice. This study explores the potential of functional connectivity (FC)-based searchlight multivariate pattern analysis (CBS-MVPA) to discriminate between schizophrenia patients and healthy controls while also predicting clinical variables.

Study Design
We enrolled 112 schizophrenia patients and 119 demographically matched healthy controls. Resting-state functional magnetic resonance imaging data were collected, and whole-brain FC subnetworks were constructed. Additionally, clinical assessments and cognitive evaluations yielded a dataset comprising 36 clinical variables. Finally, CBS-MVPA was utilized to identify subnetworks capable of effectively distinguishing between the patient and control groups and predicting clinical scores.

Study Results
The CBS-MVPA approach identified 63 brain subnetworks exhibiting significantly high classification accuracies, ranging from 62.2% to 75.6%, in distinguishing individuals with schizophrenia from healthy controls. Among them, 5 specific subnetworks centered on the dorsolateral superior frontal gyrus, orbital part of inferior frontal gyrus, superior occipital gyrus, hippocampus, and parahippocampal gyrus showed predictive capabilities for clinical variables within the schizophrenia cohort.

Conclusion
This study highlights the potential of CBS-MVPA as a valuable tool for localizing the information related to schizophrenia in terms of brain network abnormalities and capturing the relationship between these abnormalities and clinical variables, and thus, deepens our understanding of the neurological mechanisms of schizophrenia.
‘Altogether Abnormal’: Consumer-Citizens, Outsizes, and Clothes Rationing, 1941–9
Authors: Kot-Ofek Tali 
Published: May 2024

Abstract
During the Second World War and the austerity period that followed it, the British government operated clothes rationing as a welfare policy. Its official aim was to ensure that all citizens had equal access to essential clothing. Despite being associated with the principle of ‘fair shares’, rationing did not work well for large-bodied consumers. Government agents’ assumptions about citizens’ bodies generated a rationing scheme that overlooked large bodies. As a result, rationing regulations and economic controls amplified the normalizing impulses of mass production, creating a constant shortage of ready-made large garments and a market in which purchasing power and access to goods depended on body size. Struggling to navigate this market, consumers attempted to hold the government accountable for its declarations of equality. Tracing this issue in government records and in local, national, and trade press, this article discusses how the conflicting motivations of state, trade, and citizens shaped rationing in a way that prioritized the culturally and statistically ‘normal’ and reflects on what mass welfare meant for citizens with ‘abnormal’ needs.
Dirty Documents and Illegible Signatures: Doctoring the Archive of British Imperialism and Decolonization
Authors: Hebert Joel 
Published: May 2024

Abstract
This article uses the surviving records of the Hanslope disclosure to track the British government’s efforts to censor colonial archives in the era of decolonization. As staff withdrew from colonies around the world, they were instructed to either destroy or ‘migrate’ to Britain large quantities of records that held sensitive, embarrassing, or potentially incriminating details about the history of British colonial administration. Some 25,000 files were eventually shipped to the UK in a program called ‘Operation Legacy’ where they fell into legal limbo and out of institutional memory. Millions more were burned or ditched at sea. This article pursues these archival policies as they gradually evolved from Malaya to East Africa, the Caribbean, and into the post-colonial era. In giving special attention to Operation Legacy’s broader temporal and geographic sweep, this article meditates on two key points. First, while colonial officials actively learned from their colleagues in other colonies, they were forced to adapt Operation Legacy to local circumstances. The uneven application of this policy reflected the late British Empire’s status as a patchwork of sovereignties in which people were governed differently. Second, while evidence is limited, officials across disparate colonial administrations were bound together by a common impulse. They sought not only to destroy and ‘migrate’ records but also to doctor files that could then be transferred to newly independent governments. In the end, the goal was to mask the disconnect in the archives between rhetoric and reality—of the alleged aspirations of Britain’s ‘civilizing mission’ and its history of colonial violence, systemic racism, and other inconvenient truths.
‘Monty, Bring the Blood Can!’ Pulling Teeth in Working-Class Lancashire, 1900–48
Authors: Jones Claire L 
Published: May 2024

Abstract
Working-class health cultures before the National Health Service have long been of scholarly interest but those related to oral health are chronically underexamined. This article examines one important aspect of this history—tooth pulling—in early twentieth-century Lancashire. By highlighting the dynamics of market supply and demand, it demonstrates how and why the tooth pulling services of non-orthodox practitioners called dental mechanics remained popular despite the increasing monopolization of oral health by dentists. Dentists characterized mechanics as quacks, but working-class Lancastrians sought out these mechanics because they formed a trusted part of their communities. This demonstration of a population’s preference for unorthodox over orthodox practitioners provides a much-needed counter-narrative to professionalization in oral health and highlights the significance of geographically specific traditions over the values of medicine and science.
Reproductive toxicity perspectives of nanoparticles: an update
Authors: Sree B Kavya , Kumar Nitesh , Singh Sanjiv 
Published: May 2024

Abstract
Introduction: The rapid development of nanotechnologies with their widespread prosperities has advanced concerns regarding potential health hazards of the Nanoparticles. Results: Nanoparticles are currently present in several consumer products, including medications, food, textiles, sports equipment, and electrical components. Despite the advantages of Nanoparticles, their potential toxicity has negative impact on human health, particularly on reproductive health. Conclusions: The impact of various NPs on reproductive system function is yet to be determined. Additional research is required to study the potential toxicity of various Nanoparticles on reproductive health. The primary objective of this review is to unravel the toxic effects of different Nanoparticles on the human reproductive functions and recent investigations on the reproductive toxicity of Nanoparticles both in vitro and in vivo.
Antioxidant, anti-inflammatory, and anti-DNA damage effects of carnosic acid against aflatoxin B1-induced hepatic, renal, and cardiac toxicities in rats
Authors: Albadrani Ghadeer M , Altyar Ahmed E , Kensara Osama A , Haridy Mohie A M , Zaazouee Mohamed Sayed , Elshanbary Alaa Ahmed , Sayed Amany A , Abdel-Daim Mohamed M 
Published: May 2024

Abstract

Background
Aflatoxin B1 (AFB1) food contamination is a global health hazard that has detrimental effects on both human and animal health. The objective of the current study is to assess the protective impact of carnosic acid against AFB1-induced toxicities in the liver, kidneys, and heart.

Methods
Forty male Wistar Albino rats (weighting 180 ~ 200 g) were allocated into 5 groups (8 rats each); the 1st group received saline as served as a control, the 2nd group received carnosic acid (CA100) at a dose of 100 mg/kg bw/day by gavage for 14 days, the 3rd group received AFB1 at a dose of 2.5 mg/kg bw, orally twice on days 12 and 14, the 4th group (AFB1-CA50) received AFB1 as in the 3rd group and CA at a dose of 50 mg/kg bw/day, and the 5th group (AFB1-CA100) received AFB1 as in the 3rd group and CA as in the 2nd group.

Results
CA significantly decreased the liver enzymes (ALT, AST. ALP), renal function products (LDH, BUN, creatinine), and cardiac enzymes (CK and CK-MB) to control levels after the high increment by AFB1 exposure. Moreover, CA significantly decreased the oxidative stress (MDA, NO, 8-OHdG) and increased the antioxidant enzyme activities (CAT, GSH, GSH-Px, and SOD) after severe disruption of oxidant/antioxidant balance by AFB1 exposure. Interestingly, CA significantly decreased the proinflammatory mediators (IL-6, IL-1β, and TNF-α) to the control levels after severe inflammation induced by AFB1 exposure.

Conclusions
Conclusively, CA had antioxidant, anti-inflammatory, and anti-DNA damage effects against hepatic, renal, and cardiac AFB1-induced toxicities.
Hybrid-Theory Innovative Clinical Teaching Strategy
Authors: Kiel LaTashia , Sumpter Danica 
Published: May 2024

Abstract
This article introduces the Hybrid-Theory Innovative Clinical Teaching Strategy (HICTS) as a response to the challenges faced by nurse faculty in clinical education. With a shortage of clinical placements, preceptors, and evolving certification demands, faculty creativity is vital. HICTS integrates several learning theories to provide a transformative educational approach. Through shadowing and reflecting on faculty and peer actions, learners gain confidence and improved clinical reasoning. HICTS benefits faculty by reducing workload pressures and allowing personalized support. Further research is needed to determine the optimal use of HICTS and measure its impact on learner outcomes.
Association and Effect Strength of Simulation Characteristics and Transfer of Learning Attitudes in a Disaster Simulation for Prelicensure Nursing Students
Authors: Evans Cathleen A. , Roy Banibrata , Lamarra Teresa , Kobner Danielle 
Published: May 2024

Abstract
Nurse educators design simulations with the intent that students transfer previous academic learning. Transfer of learning (TOL) is a complex and abstract concept with critical literature gaps needing measurement research. This study examined the association between simulation characteristics and students’ TOL attitudes and the effect strength. This baseline study evidenced simulation design characteristics, as category groupings, were associated with students’ TOL attitudes with positive and mostly modest effects. The resulting educational implications include applying instructional design to simulation, teaching students what TOL is, and modeling thinking in the classroom for transfer to simulation.
Transcriptome and metabolome sequencing identifies glutamate and LPAR1 as potential factors of anlotinib resistance in thyroid cancer
Authors: Liu Bin , Peng Ying , Su Yanjun , Diao Chang , Qian Jun , Zhan Xiangxiang , Cheng Ruochuan 
Published: May 2024

Objective
To explore the mechanism of anlotinib resistance in thyroid carcinoma.

Methods
We constructed an anlotinib-resistant thyroid carcinoma cell line and observed the effect of drug resistance on the functional activity of these cell lines. Transcriptome sequencing and metabolomic sequencing combined with biosynthesis analysis were used to explore and screen possible drug resistance regulatory pathways.

Results
Through transcriptomic sequencing analysis of drug-resistant cell lines, it was found that the differentially expressed genes of drug-resistant strains were enriched mainly in the interleukin 17, transforming growth factor-β, calcium, peroxisome proliferator activated receptor, and other key signaling pathways. A total of 354 differentially expressed metabolic ions were screened using liquid chromatography-mass spectrometry/mass spectrometry to determine the number of metabolic ions in the drug-resistant strains. The results of the Venn diagram correlation analysis showed that glutamate is closely related to multiple pathways and may be an important regulatory factor of anlotinib resistance in thyroid carcinoma. In addition, eight common differentially expressed genes were screened by comparing the gene expression profiling interactive analysis database and sequencing results. Further quantitative real time polymerase chain reaction verification, combined with reports in the literature, showed that LPAR1 may be an important potential target.

Conclusion
This is the first study in which the drug resistance of thyroid cancer to anlotinib was preliminarily discussed. We confirmed that anlotinib resistance in thyroid cancer promotes the progression of malignant biological behavior. We conclude that glutamate may be a potential factor for anlotinib resistance in thyroid cancer and that LPAR1 is also a potentially important target.
Global Trends in and Hotspots of Bacterial Quorum Sensing: A Bibliometric Analysis for the Period 2012–2022
Authors: Miao Beiliang , Han Yu , Gao Mengqi , Yu Li , Ma Wenxin , Chen Zeliang , Zhang Ning , Liu Shiwei 
Published: May 2024

Background:
Bacterial quorum sensing (QS) plays significant roles in various fields. However, a comprehensive understanding of publication trends and research focuses within this domain remains limited. This study aimed to analyze global trends and hotspots of QS through a bibliometric analysis.

Methods:
The literature collected from the Web of Science Core Collection (WoSCC) database from 2012 to 2022 was retrieved, and then the bibliometric and visualization analyses were conducted using Co-Occurrence 13.4 (COOC), VOSviewer 1.6.19, and Pajek 5.16.

Results:
A total of 7506 papers were included and analyzed. The results revealed that the number of papers in the field of QS has increased rapidly in the last decade. The United States was the most productive and the most cited. China ranked second in terms of publications. The Chinese Academy of Science and The University of Copenhagen were the most active institutions in the field. Bonnie L. Bassler was the top-ranked author in terms of citations, thereby indicating that she was a leader in terms of academic influence in the area of QS. Further, the analysis of keywords revealed that previous studies focused on the basic mechanism, but recent research focuses on the more profound exploration of signal molecules and information exchange. Quorum quenching (QQ) and quorum sensing inhibitors (QSIs) provide directions for addressing bacterial resistance and pave the way for the development of new antimicrobial agents, which has become a hotspot and the key direction for future development in microbiological research.

Conclusion:
Our analysis provides a comprehensive overview of publication trends, research hotspots, and frontiers, which may provide guidelines for future research of QS.
Ferroptosis-related genes DUOX1 and HSD17B11 affect tumor microenvironment and predict overall survival of lung adenocarcinoma patients
Authors: Wei Chunhui , Li Lixia , Qiao Youping , Chen Yujuan , Zhang Chunfeng , Xie Jinye , Fang Jiayan , Liang Zhu , Huang Dan , Wu Dong 
Published: May 2024

Background:
Recent studies have found that ferroptosis-related genes (FRGs) have broad applications in tumor therapy. However, the predictive potential of these genes in lung adenocarcinoma (LUAD) remains to be fully characterized. We aimed to investigate the FRGs that might be potential targets for LUAD.

Methods:
We screened the RNA sequencing samples from LUAD patients from the GEO database and analyzed the ferroptosis-related differentially expressed genes (DEGs). A functional analysis of DEGs was performed. The risk model was constructed to evaluation and validation FRGs. We explored the immune landscape of LUAD and controls. The value of FRGs in diagnosing LUAD was tested in the GSE30219, GSE37745, GSE0081 datasets, and qPCR was used to verify their diagnostic value in LUAD patients in our hospital.

Results:
A total of 1327 DEGs in quantitative proteomics were obtained, of which ferroptosis-related DEGs were 259. Enrichment analysis showed significant enrichment in the absorption and metabolism of fatty acids and arachidonic acid. The upregulated genes (GCLC, RRM2, AURKA, SLC7A5, and SLC2A1) and downregulated genes (ANGPTL7, ALOX15, ALOX15B, HSD17B11, IL33, TSC22D3, and DUOX1) were selected as core genes in tissue samples from 62 patients by qPCR. DUOX1 and HSD17B11 were obtained by bioinformatics analysis, both of which showed similar expression trends at the RNA and protein levels. The Kaplan–Meier method showed that DUOX1 and HSD17B11 were closely related to the overall survival (OS) of LUAD patients.

Conclusion subsections:
Ferroptosis-related genes DUOX1 and HSD17B11 are of considerable value in the diagnosis of LUAD patients. Their low expression suggests an increased recurrence rate and leads to a decrease in the patient quality of life.