bluuebunny/crossref_metadata_2025_split huggingface dataset:
Weight loss during tuberculosis treatment is an important risk factor for drug-induced hepatotoxicity
Authors: Warmelink Ina , ten Hacken Nick H. , van der Werf Tjip S. , van Altena Richard 
Published: September 2010

The objective of this study was to determine the association between weight loss and drug-induced hepatotoxicity (DIH). A retrospective observational study of 192 active tuberculosis (TB) patients consecutively admitted in a tertiary referral TB centre in the Netherlands was conducted. The outcome measure for DIH was defined as hepatotoxicity necessitating interruption of anti-TB drugs. Multivariate logistic regression analysis on interruption of anti-TB drugs was performed, with age, sex, nutritional status, TB disease severity, drug resistance, comorbidity including baseline liver function tests, anti-TB drug regimen, co-medication and addictions as independent risk factors. Anti-TB drugs were interrupted in thirty-one patients (16·1 %). The most important risk factor was weight loss of 2 kg or more within 4 weeks during TB treatment (OR 211, 95 % CI 36·0, 1232). Other independent risk factors were infection with hepatitis C (OR 19·6, 95 % CI 2·4, 164), age over 60 years (OR 18·5, 95 % CI 2·3, 151) and multi-drug-resistant TB (OR 8·2, 95 % CI 1·3, 53·6). This study shows that weight loss during TB treatment was the most important risk factor for DIH necessitating interruption of anti-TB drugs. Causes of weight loss during TB treatment and the association between weight change and hepatotoxicity need further investigation.
Sources of sodium in Australian children's diets and the effect of the application of sodium targets to food products to reduce sodium intake
Authors: Grimes Carley A. , Campbell Karen J. , Riddell Lynn J. , Nowson Caryl A. 
Published: September 2010

The average reported dietary Na intake of children in Australia is high: 2694 mg/d (9–13 years). No data exist describing food sources of Na in Australian children's diets and potential impact of Na reduction targets for processed foods. The aim of the present study was to determine sources of dietary Na in a nationally representative sample of Australian children aged 2–16 years and to assess the impact of application of the UK Food Standards Agency (FSA) Na reduction targets on Na intake. Na intake and use of discretionary salt (note: conversion of salt to Na, 1 g of NaCl (salt) = 390 mg Na) were assessed from 24-h dietary recall in 4487 children participating in the Australian 2007 Children's Nutrition and Physical Activity Survey. Greatest contributors to Na intake across all ages were cereals and cereal-based products/dishes (43 %), including bread (13 %) and breakfast cereals (4 %). Other moderate sources were meat, poultry products (16 %), including processed meats (8 %) and sausages (3 %); milk products/dishes (11 %) and savoury sauces and condiments (7 %). Between 37 and 42 % reported that the person who prepares their meal adds salt when cooking and between 11 and 39 % added salt at the table. Those over the age of 9 years were more likely to report adding salt at the table (χ2199·5, df 6,P < 0·001). Attainment of the UK FSA Na reduction targets, within the present food supply, would result in a 20 % reduction in daily Na intake in children aged 2–16 years. Incremental reductions of this magnitude over a period of years could significantly reduce the Na intake of this group and further reductions could be achieved by reducing discretionary salt use.
Effect of dietary seaweed extracts and fish oil supplementation in sows on performance, intestinal microflora, intestinal morphology, volatile fatty acid concentrations and immune status of weaned pigs
Authors: Leonard S. G. , Sweeney T. , Bahar B. , Lynch B. P. , O'Doherty J. V. 
Published: September 2010

A 2 × 2 factorial experiment (ten sows per treatment) was conducted to investigate the effect of maternal dietary supplementation with a seaweed extract (SWE; 0v.10·0 g/d) and fish oil (FO; 0v.100 g/d) inclusion from day 109 of gestation until weaning (day 26) on pig performance post-weaning (PW) and intestinal morphology, selected microflora and immune status of pigs 9 d PW. The SWE contained laminarin (10 %), fucoidan (8 %) and ash (82 %) and the FO contained 40 % EPA and 25 % DHA. Pigs weaned from SWE-supplemented sows had higher daily gain (P = 0·063) between days 0 and 21 PW and pigs weaned from FO-supplemented sows had higher daily gain (P < 0·05) and gain to feed ratio (P < 0·01) between days 7 and 14 PW. There was an interaction between maternal SWE and FO supplementation on caecalEscherichia colinumbers (P < 0·05) and the villous height to crypt depth ratio in the ileum (P < 0·01) and jejunum (P < 0·05) in pigs 9 d PW. Pigs weaned from SWE-supplemented sows had lower caecalE.coliand a higher villous height to crypt depth ratio in the ileum and jejunum compared with non-SWE-supplemented sows (P < 0·05). There was no effect of SWE onE.colinumbers and villous height to crypt depth ratio with FO inclusion. Maternal FO supplementation induced an increase in colonic mRNA abundance of IL-1α and IL-6 (P < 0·05), while SWE supplementation induced an increase in ileal TNF-α (P < 0·01) and colonic TFF3 mRNA expression (P < 0·05). In conclusion, these results demonstrate that SWE and FO supplementation to the maternal diet influenced the gastrointestinal environment and performance of the weaned pig.
The Development of Dual Loyalties: Immigrants' Integration to Canadian Regional Dynamics
Authors: Bilodeau Antoine , White Stephen , Nevitte Neil 
Published: September 2010

Abstract.The transformations in recent patterns of immigration have the potential to reshape the trajectory of Canada's regional political dynamics. Drawing on data from the 1993–2006Canadian Election Studies, this analysis explores how immigrants adjust to the prevailing regional political norms in Quebec, Ontario, Alberta and British Columbia. Do newcomers adopt the political orientations (feelings towards Canada and their province, confidence in provincial and federal governments, perceptions about how the province is treated by the federal government and support for the Liberal party) that resemble those of their native-born provincial counterparts? The results suggest that immigrants, especially newer waves from non-traditional source countries, tend to develop orientations that are more federally oriented than the local populations in their province. This tendency is most pronounced in Quebec where both groups of immigrants from traditional and non-traditional source countries internalize political grievances and norms less efficiently than their counterparts in other provinces.Résumé.Les transformations récentes des tendances migratoires pourraient avoir un impact sur l'évolution des dynamiques politiques régionales au Canada. Cette enquête s'appuie sur les données de sondage de l'Étude électorale canadiennede 1993 à 2006 et vise à déterminer si les immigrants adoptent les attitudes et les comportements politiques dominants de leur province de résidence (Québec, Ontario, Alberta et Colombie-Britannique). Les immigrants adoptent-ils des attitudes et des comportements politiques (attachement au Canada et à la province de résidence, confiance envers les gouvernements fédéral et provincial, perception du traitement réservé par le gouvernement fédéral à la province de résidence et appui au Parti libéral du Canada) qui ressemblent à ceux des populations locales de leur province? Les résultats de l'enquête suggèrent que les immigrants, surtout ceux d'origines dites non traditionnelles, ont tendance à développer des comportements et des attitudes politiques plus orientés vers le gouvernement fédéral que ceux affichés dans leur province. Cette tendance est particulièrement marquée au Québec où les immigrants, tant d'origines traditionnelles que non traditionnelles, semblent assimiler moins efficacement que les immigrants des autres provinces les griefs et les normes politiques de la population provinciale.
Exiled, Executed, Exalted: Louis Riel, Homo Sacer and the Production of Canadian Sovereignty
Authors: Bruyneel Kevin 
Published: September 2010

Abstract. In this article, I argue that Louis Riel is a necessary invention for the production of Canadian sovereignty. The argument builds on the work of Giorgio Agamben. I see Riel as a Canadian version of homo sacer, “who may be killed but not sacrificed,” and thereby serves as the exception that proves the rule of Canadian sovereignty. I carry out this argument in three stages, focusing first on Riel's exile in 1870 after the Red River Rebellion. I then bring Agamben's insights into an examination of the tensions between French and English Canada over Riel's execution in 1885. Finally, I look at the contemporary exaltation of Riel, focusing on the two statues that have occupied the legislative grounds in Winnipeg, which, when considered in tandem, serve as a metaphor for the relationship between liberal and colonial dynamics in Canada political history. The liberal–colonial relationship is key to Riel's ambivalent standing in contemporary Canadian political life.Résumé. Dans cet article, je tente de démontrer, en m'appuyant sur le travail de Giorgio Agamben, que Louis Riel est une invention qui fut nécessaire à la création de la souveraineté canadienne. Pour moi, Riel est un homo sacer version canadienne, quelqu'un qui peut être éliminé mais non sacrifié et qui, par conséquent, représente l'exception qui confirme la règle de la souveraineté canadienne. Mon argumentaire se développe en trois étapes, mettant d'abord l'emphase sur l'exil de Louis Riel en 1870, à la suite de la rébellion de la Rivière-Rouge. En tenant compte du point de vue d'Agamben, j'analyse ensuite les tensions entre francophones et anglophones exacerbées par l'exécution de Louis Riel en 1885. Enfin, je jette un regard sur la réhabilitation de Riel dans le Canada contemporain en comparant les deux statues qui ont tour à tour orné le Palais législatif à Winnipeg. On ne peut s'empêcher d'y voir une métaphore de la relation entre les dynamiques libérale et coloniale à travers l'histoire de la politique canadienne, cette relation étant un élément clé pour comprendre le statut ambivalent de Riel dans la politique canadienne contemporaine.
Primary temporal inverted papilloma with premalignant change
Authors: Zhou H , Chen Z , Li H , Xing G 
Published: September 2010

AbstractObjectives:To explore the pathology, diagnosis, therapeutic strategies and prognosis of primary temporal inverted papilloma.Methods:We present one of the first reported cases of primary temporal inverted papilloma with premalignant change. The available data are reviewed.Results:To the best of our knowledge, only 10 evaluable cases of this tumour have been reported. The recurrence rate is higher for this tumour than for sinonasal inverted papilloma.Conclusion:Primary temporal inverted papilloma is extremely rare, and its diagnosis should be made only following clinical exclusion of sinonasal papilloma. Therapy mainly comprises radical resection of the lesion, and long-term post-operative follow up is mandatory.
Chronic suppurative otitis media in Nepal: ethnicity does not determine whether disease is associated with cholesteatoma or not
Authors: Thornton D , Martin T P C , Amin P , Haque S , Wilson S , Smith M C F 
Published: September 2010

AbstractObjectives:To determine the frequency of cholesteatoma in a population of patients with chronic suppurative otitis media, and to determine whether this frequency is affected by ethnicity.Patients:The study included 6005 patients with chronic suppurative otitis media seen during the course of 30 charitable surgical ‘ear camps’ in Nepal.Main outcome measures:Proportion of patients with each subtype of disease, and their ethnicity. A secondary outcome measure was concordance of surname with Nepalese ethnic affiliation.Results:A total of 762 patients were grouped as being of Tibeto-Mongolian origin, and 4875 as Indo-Caucasian. The rate of chronic suppurative otitis media with cholesteatoma, expressed as a proportion of the rate of all chronic suppurative otitis media subtypes, was 17.8 per cent in Tibeto-Mongolian patients and 18.6 per cent in Indo-Caucasian patients (p > 0.05). The effect of other risk factors (i.e. age, gender and geographical district) on disease distribution was also non-significant. Analysis of secondary outcome measures indicated that patients' surnames were a reliable predictor of ethnicity in this Nepalese population.Conclusion:There is almost complete concordance in proportions of patients with significant genetic, cultural, and even geographical heterogeneity, suggesting that, in Nepal, the aetiology of cholesteatoma owes little to these factors.
Animal leptospirosis in small tropical areas
Authors: DESVARS A. , CARDINALE E. , MICHAULT A. 
Published: September 2010

SUMMARYLeptospirosis is the most widespread zoonosis in the world. Humans become infected through contact with the urine of carrier animals, directly or via contaminated environments. This review reports available data on animal leptospirosis in ten tropical islands: Barbados, Martinique, Guadeloupe, Grenada, Trinidad, New Caledonia, Hawaii, French Polynesia, La Réunion and Mayotte. Leptospirosis is endemic in these insular wild and domestic fauna. Each island presents a specific panel of circulating serovars, closely linked with animal and environmental biodiversity, making it epidemiologically different from the mainland. Rats, mongooses and mice are proven major renal carriers of leptospires in these areas but dogs also constitute a significant potential reservoir. In some islands seroprevalence of leptospirosis in animals evolves with time, inducing changes in the epidemiology of the human disease. Consequently more investigations on animal leptospirosis in these ecosystems and use of molecular tools are essential for prevention and control of the human disease.
Is hand, foot and mouth disease associated with meteorological parameters?
Authors: MA E. , LAM T. , WONG C. , CHUANG S. K. 
Published: September 2010

SUMMARYWe examined the relationship between meteorological parameters and hand, foot and mouth disease (HFMD) activity. Meteorological data collected from 2000 to 2004 were tested for correlation with HFMD consultation rates calculated through the sentinel surveillance system in Hong Kong. The regression model constructed was used to predict HFMD consultation rates for 2005–2009. After adjusting for the effect of collinearity, mean temperature, diurnal difference in temperature, relative humidity, and wind speed were positively associated with HFMD consultation rates, and explained HFMD consultation rates well with 2 weeks' lag time (R2=0·119,P=0·010). The predicted HFMD consultation rates were also also well matched with the observed rates (Spearman's correlation coefficient=0·276,P=0·000) in 2005–2009. Sensitivity analysis showed that HFMD consultation rates were mostly affected by relative humidity and least affected by wind speed. Our model demonstrated that climate parameters help in predicting HFMD activity, which could assist in explaining the winter peak detected in recent years and in issuing early warning.
Que présuppose l'anaphore dite présuppositionnelle? Sur la coréférenciation des expressions nominales complètes
Authors: SALLES MATHILDE 
Published: September 2010

RÉSUMÉAvec la notion d'anaphore ‘présuppositionnelle’, Milner (1982) présente la question de la coréférenciation des expressions complètes (descriptions définies complètes et noms propres) comme une affaire de connaissances extralinguistiques sur les référents. Pourtant, les exemples dans lesquels l'interprétation coréférentielle parvient à s’établir indépendamment de ce type de connaissances ne sont pas si rares. Le rôle des relations de cohérence est ici primordial, mais il l'est aussi pour l'interprétation des expressions incomplètes. L'originalité de l'anaphore présuppositionnelle est donc ailleurs: dans ses affinités avec une relation de cohérence particulière – la relation d’Elaboration– et l'association entre relations de cohérence et relations paratextuelles.
Impact on caregiver burden of a patient-focused palliative care intervention for patients with advanced cancer
Authors: O'Hara Ross E. , Hull Jay G. , Lyons Kathleen D. , Bakitas Marie , Hegel Mark T. , Li Zhongze , Ahles Tim A. 
Published: September 2010

AbstractObjective:Caregivers of patients with advanced cancer experience physical and emotional strain that can raise their own risk for morbidity and mortality. This analysis was performed to determine whether ENABLE II, a patient-focused palliative care intervention that increased patients' quality of life, reduced symptom intensity, and lowered depressed mood compared to usual care, would affect caregiver burden.Method:Caregivers of patients with advanced cancer from the parent study completed a caregiver burden scale and patients completed quality of life, symptom intensity, and depressed mood measures. Data were collected at baseline, 1 month, and every 3 months thereafter until patient death or the study ended. Decedents' caregivers were asked to complete an after-death interview regarding the quality of care that the patient received.Results:There were no significant differences in caregiver burden between intervention and usual care conditions. Follow-up analyses showed that higher caregiver objective burden and stress burden were related to lower patient quality of life, higher symptom intensity, and higher depressed mood. Caregivers who perceived that patients had unmet needs at end of life reported higher objective burden, and those who perceived that patients were not treated with respect reported higher demand burden.Significance of results:The results indicate that a successful patient-focused intervention did not have a similar beneficial effect on caregiver burden. Future interventions should focus on caregivers as well as patients, with particular attention to caregivers' perceptions of patient care, and seek to change both negative and positive effects of informal caregiving.
Transforming the mortality review conference to assess palliative care in the acute care setting: A feasibility study
Authors: Pekmezaris Renee , Cooper Lynda , Efferen Linda , Mastrangelo Amy , Silver Alan , Eichorn Ann , Walia Rajni , Mir Tanveer , Liberman Tara , Weiner Joseph , Steinberg Harry 
Published: September 2010

AbstractObjective:This project sought to evaluate the impact of a hospital-based Palliative Care Consultation (PCC) service utilizing a common practice: the resident mortality review conference.Method:Internal Medicine residents used a revised chart audit tool during the mortality review conference, which included domains described in the Clinical Practice Guidelines for Quality Palliative Care (2004). This study attempted to transform the common practice into a methodology for collecting data that could be used as a platform to assess the quality of hospital care near the end of life. In this review, the residents were asked not only “what care was delivered appropriately?” but “what could we have done?” to relieve the patient's and family's suffering.Results:The results showed that the mortality review process could be used to assess care at the end of life. It also showed that those patients who received a PCC received better care. Symptoms were addressed at a significantly higher rate for those patients who received a PCC than for those who did not. Specifically, these were symptoms of pain (75% vs. 51%, p <.0001), dyspnea (75% vs. 59%, p < 0.0001), nausea (28% vs. 18%, p < 0.0001), and agitation (53% vs. 33%, p < 0.0001).Significance of results:The mortality review process was found to be valuable in assessing care delivery for patients near the end of life. The tool yielded results that were consistent with findings of other studies looking at pain and symptom management, advance care planning, and the rate of palliative care consults across major diagnostic categories, supporting the face validity of the mortality review process.
Comparison of experienced burnout symptoms in specialist oncology nurses working in hospital oncology units or in hospices
Authors: Ostacoli Luca , Cavallo Marco , Zuffranieri Marco , Negro Manuela , Sguazzotti Erica , Picci Rocco Luigi , Tempia Patrizia , La Ciura Pietro , Furlan Pier Maria 
Published: September 2010

AbstractObjective:This study aimed to clarify the differential contributions of situational and individual factors to burnout symptoms experienced by two independent groups of specialist oncology nurses working in oncology hospital units or in hospices.Method:The study involved a group of specialist oncology nurses working in hospital oncology units (n = 59) and a group of specialist oncology nurses working in hospices (n = 33). Participants were invited to provide demographic data, and indicate the clinical setting in which they worked and their work experience; the Italian versions of the Maslach Burnout Inventory (MBI) (a measure of burnout symptoms), the Hospital Anxiety and Depression Scale (HADS) (a measure of anxiety and depression), and the Attachment Style Questionnaire (ASQ) (a measure of relational style) were then administered.Results:The two groups of nurses were well matched for age, work experience, and levels of anxiety and depression. Regarding their relational style, the two groups only differed significantly on two subscales of the ASQ (i.e. “Confidence” and “Relationships as Secondary”). The two groups significantly differed in the levels of all burnout symptoms investigated (emotional exhaustion, depersonalization, and personal achievement), with nurses working in hospital units showing higher levels of burnout symptoms. Interestingly, multivariate regression analyses showed that the institutional factor (clinical setting in which nurses worked) clearly emerged as the only factor that influenced the level of all burnout symptoms, whereas the contribution of individual factors was less significant.Significance of results:These findings help to clarify the differential contributions of institutional and individual factors to burnout symptoms in specialist oncology nurses, and corroborate the need for interventions to contain nurses' burnout symptoms.
What does care mean? Perceptions of people approaching the end of life
Authors: Janssen Anna L. , MacLeod Roderick D. 
Published: September 2010

AbstractObjective:This project sought to better understand the nature of medical care from the perspective of people approaching the end of life.Method:We asked 13 people who were dying (and a family member for each) to describe their care and the ways in which doctors' behavior fosters or inhibits the feeling that they were cared for as individuals. Interviews took a phenomenological approach. Data analysis was thematic.Results:Examples used by participants as evidence of care varied widely and showed the potentially complex nature of quality care. Participants' descriptions reflect the many ways people can impart and experience care as unique individuals in the medical context. They also provide clear examples of what uncaring behaviour looks and feels like.Significance of results:The importance of care was clearly illustrated through descriptions of the benefits of caring behavior and the negative consequences of uncaring behavior. In order to demonstrate the empathy and compassion expected and assumed of medical graduates and engender a feeling of being cared for among their patients, doctors need to invite and develop a relationship with those they are caring for. There needs to be a focus on each member of the caring relationship primarily as individual human beings.