bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prostate-Specific Membrane Antigen as a Potential Novel Vascular Target for Treatment of Glioblastoma Multiforme
Authors: Wernicke A Gabriella , Edgar Mark A. , Lavi Ehud , Liu He , Salerno Pamela , Bander Neil H. , Gutin Philip H. 
Published: October 2011

Context.—Prostate-specific membrane antigen (PSMA) is expressed in endothelium of vessels in malignant solid tumors but not in normal vessels.
Objective.—To examine whether neovasculature of glioblastoma multiforme (GBM) expresses PSMA.
Design.—After institutional review board approval at Memorial Sloan-Kettering Cancer Center, formalin-fixed paraffin-embedded tissue from 32 patients who underwent a maximally safe neurologic resection during 2004 to 2005 for GBM (World Health Organization criteria) was obtained. We performed immunohistochemical staining on the vessels of the GBM specimens for PSMA expression in tumor endothelium. The tissue samples were also stained for CD31 to verify that the PSMA was staining tumor vessels. The PSMA percent staining was scored: less than 5%, 6% to 25%, 26% to 50%, 51% to 75%, and 76% to 100%. Staining intensity was ranked as follows: 0 (none), 1+ (faint), 2+ (moderately-intense), and 3+ (maximum-intensity).
Results.—Immunohistochemical staining on the vessels of 32 paraffin-embedded GBM specimens revealed that all 32 (100%) specimens exhibited staining for PSMA to a variable extent. Of these, 22 of 32 specimens (69%) had more than 51% vascular staining for PSMA. The intensity of staining was 2+ to 3+ in most of the specimens (29 of 32; 91%).
Conclusions.—Prostate-specific membrane antigen is expressed in the vasculature of GBM vessels, thus rendering a potential novel therapeutic vascular target. A clinical trial with a cytotoxin-conjugated antibody to PSMA is planned.
Copper‐Catalyzed Aerobic Oxidative CH Functionalizations: Trends and Mechanistic Insights
Authors: Wendlandt Alison E. , Suess Alison M. , Stahl Shannon S. 
Published: October 2011

AbstractThe selective oxidation of CH bonds and the use of O2 as a stoichiometric oxidant represent two prominent challenges in organic chemistry. Copper(II) is a versatile oxidant, capable of promoting a wide range of oxidative coupling reactions initiated by single‐electron transfer (SET) from electron‐rich organic molecules. Many of these reactions can be rendered catalytic in Cu by employing molecular oxygen as a stoichiometric oxidant to regenerate the active copper(II) catalyst. Meanwhile, numerous other recently reported Cu‐catalyzed CH oxidation reactions feature substrates that are electron‐deficient or appear unlikely to undergo single‐electron transfer to copper(II). In some of these cases, evidence has been obtained for the involvement of organocopper(III) intermediates in the reaction mechanism. Organometallic CH oxidation reactions of this type represent important new opportunities for the field of Cu‐catalyzed aerobic oxidations.
Rapid and economic chiral‐HPLC method of nebivolol enantiomers resolution in dosage formulation
Authors: Al‐Othman Zeid A. , Ali Imran 
Published: October 2011

ABSTRACTA fast, economic, reproducible, accurate, effective, rugged and selective chiral‐HPLC method was developed and validated for the enantiomeric resolution of nebivolol enantiomers [(+)‐RRRS and (−)‐SSSR)] in dosage formulation. The method was rapid as chiral separation occurred within only 12 min. The mobile phase used was n‐heptane–ethanol–DEA (85:15:0.1, v/v) at 3.0 mL/min flow‐rate with 225 nm detection. The column used was an amylase‐based 3‐AmyCoat (150 × 46 mm) [tris‐(3,5‐dimethylphenyl carbamate)]. The capacity factors of (+)‐RRRS and (−)‐SSSR enantiomers were 7.85 and 10.90 while the separation and resolution factors were 1.39 and 1.83, respectively. The limits of detection and quantitation for (+)‐RRRS enantiomer were 4.5 and 10.00 µg/mL, while these values for (−)‐SSSR enantiomer were 4.1 and 8.2 µg/mL, respectively. The linearity was observed in the concentrations range of 0.10–1.0 mg/mL for both enantiomers. The π–π interactions, hydrogen bonds, dipole–dipole interactions and steric effects control the chiral resolution of nebivolol enantiomers on the reported chiral column. The reported method can be used for the quality control of nebivolol in pharmaceutical preparations with good economy. In addition, this method can also be used for the analysis of (+)‐RRRS and (−)‐SSSR) enantiomers in biological and environmental samples. Copyright © 2011 John Wiley & Sons, Ltd.
Liquid Phase Adsorption of Phenol and Chloroform by Activated Charcoal
Authors: Alwary L. , Gafar M. , Rumie A. 
Published: October 2011

AbstractThe adsorption equilibria of phenol and chloroform from aqueous solutions on four different particle sizes of activated charcoal were examined at different initial concentrations of the adsorbates. The experimental data were analyzed using the Langmuir and Freundlich isotherm models. Both models fit the adsorption data for phenol. The Freundlich model more accurately fits the adsorption data for chloroform than the Langmuir model. The sorption kinetics for phenol was studied using pseudo‐first‐order and second‐order kinetic models. The adsorption data better fit the second‐order model. The results of the study show that activated charcoal can be used as potential adsorbent for phenol and chloroform in drinking water.
Dimensionless Formulation of Convective Heat Transfer in Fry‐Drying of Sewage Sludge
Authors: Romdhana M. H. , Lecomte D. , Ladevie B. 
Published: October 2011

AbstractFry‐drying is an alternative for heat and mass transfer intensification. The process reuses waste oil as a heating medium for drying by contact with the wet sludge. At the end of the process, a stable derived fuel is obtained, a granular solid composed of the dried indigenous sewage solid and the impregnated oil. The fry‐dried sludge is storable and transportable without any pathogen elements. Knowledge about heat and mass transfer rates during the frying process is essential in order to assess the quality of the final product such as calorific value, oil uptake, porosity changes, etc. The heat transfer properties including transfer by free convection between the solid and the frying oil are fundamental for the process design and manufacturing of the fry‐dried product. The convective heat coefficient by temperature measurement and overall energy balance calculation is determined. The heat flux is calculated from the fry‐drying kinetics including moisture loss and oil intake kinetics. Various hydrodynamic regimes for convective heat transfer during the frying process are discussed (non‐boiling, boiling, and low‐boiling regime). A dimensionless formulation for estimating the convective transfer is proposed.
Noncatalytic Biodiesel Fuel Production from Croton megalocarpus Oil
Authors: Kafuku G. , Tan K. T. , Lee K. T. , Mbarawa M. 
Published: October 2011

AbstractBiodiesel is currently considered as the most promising substitute for diesel fuel because of its similar properties to diesel. This study presents the use of the supercritical methanol method in the production of biodiesel from Croton megalocarpus oil. The reaction parameters such as methanol‐to‐oil ratio, reaction temperature and reaction time were varied to obtain the optimal reaction conditions by design of experiment, specifically, response surface methodology based on three‐variable central composite design with α = 2. It has been shown that it is possible to achieve methyl ester yields as high as 74.91 % with reaction conditions such as 50:1 methanol‐to‐oil molar ratio, 330 °C reaction temperature and a reaction period of 20 min. However, Croton‐based biodiesel did not sustain higher temperatures due to decomposition of polyunsaturated methyl linoleate, which is dominant in biodiesel. Lower yields were observed when higher temperatures were used during the optimization process. The supercritical methanol method showed competitive biodiesel yields when compared with catalytic methods.
Elucidation of the Chemical and Morphological Structure of Double‐Network (DN) Hydrogels by High‐Resolution Magic Angle Spinning (HRMAS) NMR Spectroscopy
Authors: Shestakova Pavletta , Willem Rudolph , Vassileva Elena 
Published: October 2011

Abstract1H HRMAS NMR spectroscopy is applied to gain insight into the chemical and morphological structure of double‐network (DN) hydrogels, prepared from poly(2‐acrylamido‐2‐methyl‐1‐propanesulfonic acid) (PAMPS) and poly(acrylamide) (PAAm). The method enables one to obtain detailed information at the molecular level about the formation of covalent bonds between the two polymer networks through non‐reacted double bonds of the cross‐linker N,N′‐methylene bis(acrylamide) (MBAA). Evidence to the existence of strong hydrogen‐bond interactions based on the NH group of the PAMPS as a hydrogen‐bond donor and the CO group of the PAAm as a hydrogen‐bond acceptor is also provided. These findings clarify the origin of the toughening mechanism and the exceptionally strong mechanical properties of DN gels, further supported by microhardness data.
Identification of a novel, recurrent HEY1‐NCOA2 fusion in mesenchymal chondrosarcoma based on a genome‐wide screen of exon‐level expression data
Authors: Wang Lu , Motoi Toru , Khanin Raya , Olshen Adam , Mertens Fredrik , Bridge Julia , Cin Paola Dal , Antonescu Cristina R. , Singer Samuel , Hameed Meera , Bovee Judith V.M.G. , Hogendoorn Pancras C. W. , Socci Nicholas , Ladanyi Marc 
Published: October 2011

AbstractCancer gene fusions that encode a chimeric protein are often characterized by an intragenic discontinuity in the RNA\expression levels of the exons that are 5′ or 3′ to the fusion point in one or both of the fusion partners due to differences in the levels of activation of their respective promoters. Based on this, we developed an unbiased, genome‐wide bioinformatic screen for gene fusions using Affymetrix Exon array expression data. Using a training set of 46 samples with different known gene fusions, we developed a data analysis pipeline, the “Fusion Score (FS) model”, to score and rank genes for intragenic changes in expression. In a separate discovery set of 41 tumor samples with possible unknown gene fusions, the FS model generated a list of 552 candidate genes. The transcription factor gene NCOA2 was one of the candidates identified in a mesenchymal chondrosarcoma. A novel HEY1‐NCOA2 fusion was identified by 5′ RACE, representing an in‐frame fusion of HEY1 exon 4 to NCOA2 exon 13. RT‐PCR or FISH evidence of this HEY1‐NCOA2 fusion was present in all additional mesenchymal chondrosarcomas tested with a definitive histologic diagnosis and adequate material for analysis (n = 9) but was absent in 15 samples of other subtypes of chondrosarcomas. We also identified a NUP107‐LGR5 fusion in a dedifferentiated liposarcoma but analysis of 17 additional samples did not confirm it as a recurrent event in this sarcoma type. The novel HEY1‐NCOA2 fusion appears to be the defining and diagnostic gene fusion in mesenchymal chondrosarcomas. © 2011 Wiley Periodicals, Inc.
Contemporary management of lymph node metastases from an unknown primary to the neck: I. A review of diagnostic approaches
Authors: Strojan Primož , Ferlito Alfio , Medina Jesus E. , Woolgar Julia A. , Rinaldo Alessandra , Robbins K. Thomas , Fagan Johannes J. , Mendenhall William M. , Paleri Vinidh , Silver Carl E. , Olsen Kerry D. , Corry June , Suárez Carlos , Rodrigo Juan P. , Langendijk Johannes A. , Devaney Kenneth O. , Kowalski Luiz P. , Hartl Dana M. , Haigentz Missak , Werner Jochen A. , Pellitteri Phillip K. , de Bree Remco , Wolf Gregory T. , Takes Robert P. , Genden Eric M. , Hinni Michael L. , Mondin Vanni , Shaha Ashok R. , Barnes Leon 
Published: October 2011

AbstractIn an era of advanced diagnostics, metastasis to cervical lymph nodes from an occult primary tumor is a rare clinical entity and accounts for approximately 3% of head and neck malignancies. Histologically, two thirds of cases are squamous cell carcinomas (SCCs), with other tissue types less common in the neck. With modern imaging and tissue examinations, a primary tumor initially undetected on physical examination is revealed in >50% of patients and the site of the index primary can be predicted with a high level of probability. In the present review, the range and limitations of diagnostic procedures are summarized and the optimal diagnostic workup is proposed. Initial preferred diagnostic procedures are a fine‐needle aspiration biopsy (FNAB) and imaging. This allows directed surgical biopsy (such as tonsillectomy), based on the preliminary findings, and prevents misinterpretation of postsurgical images. When no primary lesion is suggested after imaging and panendoscopy, and for patients without a history of smoking and alcohol abuse, molecular profiling of an FNAB sample for human papillomavirus (HPV) and/or Epstein–Barr virus (EBV) is important. Head Neck, 2013
Investing in Italian photovoltaics
Authors: Lanzavecchia Alberto , Szpitalak Anton 
Published: October 2011

AbstractThe European Union as a whole is on track to exceed its self‐imposed target of deriving at least 20 percent of its energy consumption from renewable sources by the year 2020. Ten EU member states expect to exceed their targets. But Italy is lagging behind.However, Italy is the only country falling short of its goal that intends to make up the deficit by joint projects with other countries. This makes Italy a good target for foreign firms who want to invest in Italian photovoltaic technology, according to the authors of this article. And they offer a step‐by‐step guide for foreign investors. © 2011 Wiley Periodicals, Inc.
Sonographic appearance of intrathoracic kidney in a fetus with left diaphragmatic hernia
Authors: Hidaka Nobuhiro , Fujita Yasuyuki , Satoh Yuka , Fukushima Kotaro , Wake Norio 
Published: October 2011

AbstractAlthough prenatal diagnosis of congenital diaphragmatic hernia is not a rare event, detection of intrathoracic kidney in association is extremely rare. We present the sonographic findings in such a case. The postnatal outcome after successful respiratory management and surgical repair was good. © 2011 Wiley Periodicals, Inc. J Clin Ultrasound, 2011
A behavioral approach to strategy—what's the alternative?
Authors: Levinthal Daniel A. 
Published: October 2011

AbstractThe strategy field has generally been viewed as somewhat fragmented with the primary ‘fault line’ stemming from the divide between economic and behavioral approaches. It is argued here that this is a false divide as any but the most trivial problems require a behavioral act of representation prior to invoking a deductive, ‘rational’ approach. In this sense, all approaches are behavioral. Once we recognize rationality as a process, then the pragmatic question becomes which among the imperfect mechanisms to guide choice and behavior may be more or less preferred. Such a viewpoint not only serves to help span the chasm of behavioral and economic approaches, but it may also connect the applied normative frameworks and approaches within the field to more theoretically grounded approaches. Copyright © 2011 John Wiley & Sons, Ltd.
Psychological foundations of dynamic capabilities: reflexion and reflection in strategic management
Authors: Hodgkinson Gerard P. , Healey Mark P. 
Published: October 2011

AbstractIn recent years, there has been a move to identify the behavioral foundations underpinning the evolutionary and economic fitness of the enterprise. Indeed, the dynamic capabilities project now occupies center stage in the field of strategic management. Yet the accounts developed thus far—like much of the field's theory and research more generally—are predicated upon a cold cognition logic that downplays the significance of emotional/affective and nonconscious cognitive processes for strategic adaptation. In this article, we rectify this imbalance by drawing upon contemporary advances in social cognitive neuroscience and neuroeconomics to develop a series of countervailing insights and new prescriptions for the development of dynamic capabilities. Using Teece's (2007) influential framework to organize and illustrate our arguments, we demonstrate how the fundamental capabilities of sensing, seizing, and transforming each require firms to harness the cognitive and emotional capacities of individuals and groups to blend effortful forms of analysis with the skilled utilization of less deliberative, intuitive processes. Copyright © 2011 John Wiley & Sons, Ltd.
Behavioral strategy
Authors: Powell Thomas C. , Lovallo Dan , Fox Craig R. 
Published: October 2011

AbstractBehavioral strategy merges cognitive and social psychology with strategic management theory and practice. Despite much progress, the aims and boundaries of behavioral strategy remain unclear. In this paper we define behavioral strategy and identify the main unsolved problems. We propose a unifying conceptual framework for behavioral strategy and conclude by introducing the papers of the Special Issue on the Psychological Foundations of Strategic Management. Copyright © 2011 John Wiley & Sons, Ltd.
Neurostrategy
Authors: Powell Thomas C. 
Published: October 2011

AbstractBrain research has contributed to economics, marketing, law, and other fields. Does strategic management need neuroscience? This paper examines the potential contributions of brain research to strategic management research and practice. The paper discusses the aims and methods of neuroscience, its strengths and limitations in social and economic research, and its potential contributions to strategy. The paper identifies specific research questions at the intersection of strategy and neuroscience and appraises the prospects for substantive collaborations between neuroscientists and scholars in strategic management. Copyright © 2011 John Wiley & Sons, Ltd.
Reflecting the choice and usage of communication tools in global software development projects with media synchronicity theory
Authors: Niinimäki Tuomas , Piri Arttu , Lassenius Casper , Paasivaara Maria 
Published: October 2011

SUMMARYGlobal software development (GSD) projects use a variety of communication tools, such as teleconferences, email, and instant messaging to overcome the challenges caused by distribution. The use of different tools implies different communication needs and practices within the project. Media synchronicity theory (MST) breaks communication down into two processes — conveyance of information and convergence of understanding — and communication media capabilities into five: immediacy of feedback, parallelism, symbol variety, rehearsability, and reprocessability. According to MST, media capabilities differ in support for conveyance and convergence, and for good performance, there should be match between media capabilities and communication process needed in a given task. In this paper, we present our qualitative study on communication in GSD. We interviewed 79 individuals from 12 GSD projects. We discuss which communication tools were used and how. We analyze the tool use and articulated rationale for choosing the tools for various tasks in distributed software development based on the two communicative processes and five media properties suggested by MST. We found evidence supporting the applicability of MST as an aid in selecting communication tools for GSD projects. Copyright © 2011 John Wiley & Sons, Ltd.
Olanzapine suppresses the rewarding and discriminative stimulus effects induced by morphine
Authors: Torigoe Kazuhiro , Mori Tomohisa , Shibasaki Masahiro , Yoshizawa Kazumi , Narita Minoru , Suzuki Tsutomu 
Published: October 2011

AbstractAtypical antipsychotic medications are effective for treating both the positive and negative symptoms of schizophrenia. Olanzapine is an atypical antipsychotic that blocks dopaminergic, serotonergic, adrenergic, histaminergic, and muscarinic receptors. In this study, we used rodents to investigate whether olanzapine could suppress the hyperlocomotion, rewarding effect, and discriminative stimulus effect induced by the prototypic μ‐opioid morphine, which are all considered to reflect the abuse potential or psychoactive effects of μ‐opioids. Olanzapine at doses that failed to induce motor coordination produced a dose‐dependent reduction in hyperlocomotion induced by morphine in mice. Olanzapine at a dose that did not produce motor dysfunction also inhibited the significant place preference induced by morphine in mice. Furthermore, the discriminative stimulus effect induced by morphine in rats was dose‐dependently and significantly attenuated by olanzapine at the dose that did not induce the motor dysfunction. These results suggest that treatment with both μ‐opioids and olanzapine at a dose lower than that at which it induces motor dysfunction could be very useful for preventing the abuse potential and/or psychoactive effects of μ‐opioids. Synapse, 2012. © 2011 Wiley Periodicals, Inc.
Relationship between domestic violence and postnatal depression among pregnant Chinese women
Authors: Zhang Yong , Zou Shaohong , Cao Yuping , Zhang Yalin 
Published: October 2011

AbstractObjectiveTo investigate the prevalence of domestic violence during pregnancy and postnatal depression, and to explore the relationship between domestic violence and postnatal depression among Chinese women.MethodsIn a cross‐sectional survey, 846 pregnant women were screened with the Abuse Assessment Screen; 215 women completed the postnatal follow‐up. All participants underwent psychosocial assessment, with the Edinburgh Postpartum Depression Scale being used for the evaluation of postnatal depression.ResultsThe overall prevalence of domestic violence during pregnancy was 11.3%, and the most common form of domestic violence was psychologic abuse. The follow‐up interviews showed a higher prevalence of postnatal depression among women who had been abused during pregnancy (25.1%) than among those who had not (6.0%). Psychologic abuse during pregnancy, an unexpected pregnancy, an attitude of acceptance toward violence, and concern over the newborn's health were related with postnatal depression.ConclusionDomestic violence during pregnancy and related factors contributed to postnatal depression in a population of Chinese women. The findings emphasize the importance of intervention among vulnerable populations in low‐income countries.