bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effectiveness of medium‐dose ultraviolet A1 phototherapy in localized scleroderma
Authors: Su Ozlem , Onsun Nahide , Onay Hulya Kapran , Erdemoglu Yeliz , Ozkaya Dilek Biyik , Cebeci Filiz , Somay Adnan 
Published: July 2011

AbstractBackground  Recently, ultraviolet (UV) A1 phototherapy has been suggested as an effective treatment for localized scleroderma (LS); however, the optimal dose of UVA1 still has not been determined.Objective  We aimed to evaluate the therapeutic effectiveness of medium‐dose (30 J/cm2) UVA1 phototherapy and to show that 13 MHz ultrasound is a valuable tool for assessing the results of UVA1 phototherapy in LS.Methods  Thirty‐five patients with LS were treated with medium‐dose (30 J/cm2) UVA1. In total, 30–45 treatments and 900–1350 J/cm2 cumulative UVA1 doses were evaluated by clinical scoring in all patients. In 14 patients, skin thickness was also determined by 13 MHz ultrasound examination.Results  In all patients, medium‐dose UVA1 therapy softened sclerotic plaques, and marked clinical improvement was observed in 29 of 35 (82. 85%) patients. Ultrasound measurements showed that skin thickness was significantly reduced. No side effects were observed during or after treatment.Conclusion  Medium‐dose UVA1 phototherapy is a highly effective, safe, and well‐tolerated therapeutic modality for treatment of all types of LS. A 13 MHz ultrasound probe may be used for evaluating UVA1 phototherapy results.
Successful treatment of Rowell syndrome using oral cyclosporine A
Authors: Müller Cornelia S. L. , Hinterberger Louisa R. , Vogt Thomas 
Published: July 2011

AbstractBackground  To present and discuss successful treatment of Rowell syndrome with low dose orally administered cyclosporine in a male patient with refractory course of disease.Methods  A 63‐year‐old male patient presented with a five‐week history of widespread, severely pruritic erythematous skin changes that were first seen on the back. Within a few weeks, skin rashes extended to the whole body recessing the face. Because treatment with topical and orally administered corticosteroids was ineffective, we began an immunosuppressive therapy using cyclosporine. Treatment was initiated with an orally administered dosage of 100mg/day and subsequent dose reduction to 50mg/day after 14 days.Result  After four weeks of treatment, all clinical signs were resolved; only postinflammatory hyperpigmentation persisted for several weeks. Treatment‐related side effects included arterial hypertension that could be controlled with antihypertensive drugs.Conclusion  Primarily described in 1963, Rowell syndrome represents the combination of cutaneous lupus erythematosus and erythema multiforme in a single individual. Controversial discussion concerning the genuine character of the disease is still going on, and even the existence of this entity remains unclear. Several therapeutic regimes are known, including corticosteroids, methotrexate, or dapsone. To the best of our knowledge, this is the first report of successful treatment of Rowell syndrome with low doses of cyclosporine. Orally administered low‐dose cyclosporine seems to be a potent alternative treatment option for patients with Rowell syndrome refractory to standard therapies.
Paraneoplastic autoimmune multiorgan syndrome: 20 years after
Authors: Czernik Annette , Camilleri Michael , Pittelkow Mark R. , Grando Sergei A. 
Published: July 2011

AbstractThe purpose of this review is to provide insight and clarification in the quandary of classification and delineate clinical and histological features and pathophysiology of paraneoplastic pemphigus. This is a paraneoplastic disease of epithelial autoimmunity and adhesion originally described by Dr. Anhalt in 1990. Paraneoplastic pemphigus represents only one manifestation of the heterogeneous autoimmune syndrome in which patients, in addition to small airways occlusion, may display a spectrum of at least five clinical variants of the mucocutaneous disease [i.e. pemphigus‐like, pemphigoid‐like, erythema multiforme‐like, graft‐versus‐host disease‐like, and lichen planus‐like, termed paraneoplastic autoimmune multiorgan syndrome (PAMS)]. There is a need for the expanded, inclusive classification of diverse mucocutaneous and respiratory presentations of PAMS. Multiple specific effectors of humoral and cellular autoimmunity mediating epithelial damage have been identified. An update of advances in clinical and basic research on PAMS and in management and overall prognosis of PAMS is provided.
Human T‐lymphotropic Virus 1 (HTLV‐1) infection – dermatological implications
Authors: Amano Masahiro , Setoyama Mitsuru , Grant Annika , Kerdel Francisco A. 
Published: July 2011

AbstractHuman T‐lymphotropic virus type 1 (HTLV‐1) is a type C retrovirus primarily endemic to Japan, Central and South America, the Middle East, regions of Africa, and the Caribbean. Currently, an estimated 10–20 million people worldwide are infected with this virus. Although the majority of infected individuals remain asymptomatic, HTLV‐1 is the causative agent of a number of disorders, notably adult T‐cell leukemia/lymphoma (ATLL) and a progressive demyelinating neurological disorder, HTLV‐1‐associated myelopathy/tropical spastic paraparesis (HAM/TSP). In addition to ATLL and HAM/TSP, HTLV‐1 has been associated with a spectrum of skin disorders, such as infective dermatitis associated with HTLV‐1, crusted scabies, and leprosy. The understanding of the interaction between virus and host response has improved markedly, but there are still few treatment options.
Sensitive skin in the American population: prevalence, clinical data, and role of the dermatologist
Authors: Misery Laurent , Sibaud Vincent , Merial‐Kieny Christelle , Taieb Charles 
Published: July 2011

AbstractIntroduction  Sensitive skin is a complex dermatological condition, defined by abnormal sensory symptoms. The aim of this epidemiological survey was to assess the prevalence of sensitive skin and collect data on sensitive skin in the US population.Methods  A phone survey was conducted in the USA by a poll institute in 2007. A sample was drawn from a representative national cohort of the American population at least 18 years of age through the quota method. Data on demographic characteristics, environmental and climatic factors, skin characteristics, dermatological disorders, cosmetics use, and visits to the dermatologist were collected.Results  Of 994 subjects who answered (495 men and 499 women), 44.6% declared having “sensitive” or “very sensitive” skin. Women were more concerned than men (50.9% vs. 38.2%, P < 0.0001). There was no significant difference related to geographic localization, age, or ethnic distribution. Subjects with sensitive skin had mainly dry (34.5%) or mixed skin (35.7%), fair phototypes, dermatological disorders, higher skin reactivity to cosmetics and various environmental factors in comparison with subjects who stated having only a “slightly” sensitive or not sensitive skin. The dermatologist had a strong influence on subjects with “sensitive” or “very sensitive” skin through the prescription of skin care products.Conclusion  This study, based on a representative sample of the American population, reveals a high prevalence of sensitive skin in the USA. Sensitive skin is mainly associated with dry skin, fair phototype, reactivity to climatic and environmental factors, and cosmetics. American dermatologists seem largely involved in the care of this condition.
Long‐term follow‐up of metil aminolevulinate (MAL)‐PDT in difficult‐to‐treat cutaneous Bowen’s disease
Authors: Cavicchini Stefano , Serini Stefano Maria , Fiorani Roberta , Girgenti Valentina , Ghislanzoni Massimo , Sala Francesco 
Published: July 2011

AbstractBowen’s disease (BD) is a form of intraepidermal squamous cell carcinoma, which is clinically characterized by gradually enlarging, well‐demarcated erythematous plaques with irregular borders and surface crusting or scaling, affecting primarily the elderly.BD often presents with lesions difficult to treat with standard therapy as surgery, cryosurgery, or 5‐fluorouracil (5‐FU) for the risk of significantly poor cosmetic outcome, failure rate, and adverse events, related mainly to the age of the patients. Topical PDT with methyl aminolevulinate (MAL) represents a valid and approved therapy for BD lesions in many cases, especially for lesions located at poor healing sites or for large patches of disease, due to its high efficacy coupled with good tolerability and tissue‐sparing attitude. In this study, we sought to investigate the efficacy, safety, and cosmetic outcome of MAL‐PDT in a series of patients with BD lesions which were challenging to treat for clinical, surgical, and patient‐related reasons, such as size of the lesion, difficult surgical approach for anatomical sites, or age of patients and request of the best cosmetic result. We also performed a long‐term follow‐up to assess recurrence rates and eventual late‐onset adverse events.
Chronic cocaine self‐administration modulates ERK1/2 and CREB responses to dopamine receptor agonists in striatal slices
Authors: Hoffmann Hanne M. , Nadal Roser , Vignes Michel , Ortiz Jordi 
Published: August 2011

ABSTRACTCocaine abuse leads to adaptations in brain reward circuits, where dopaminergic neurotransmission is a fundamental component. We hypothesized that chronic cocaine self‐administration could influence dopamine D1 and D2 receptor activation of extracellular signal‐regulated protein kinase 1 and 2 (ERK1/2) and cyclic adenosine monophosphate response element‐binding protein (CREB) phosphorylation. Male Sprague Dawley rats were exposed to cocaine self‐administration for 6–11 weeks. Brains from sham controls and cocaine rats were extracted 1 day after the last session, and slices obtained from the striatum and nucleus accumbens (NAc) were incubated in vitro with or without the D1R agonist SKF38393 or the D2R agonist quinpirole. We found that cocaine self‐administration led to a reduction in the capacity of D1R to activate ERK1/2 phosphorylation as compared with control rats. Cocaine self‐administration also reduced D1R agonist‐induced CREB phosphorylation in striatal slices, suggesting a downregulation of D1R signaling. D2R‐induced ERK1/2 phosphorylation appeared blunted in striatal slices from cocaine rats. In contrast, surprisingly, cocaine self‐administration strongly potentiated D2R agonist‐induced CREB phosphorylation selectively in the NAc portion of the slices. Altered agonist‐induced signaling was independent of total ERK1/2 and CREB expression. Our finding that selected cellular D2R responses to CREB were strengthened by cocaine self‐administration could be relevant to understand how dopaminergic receptors participate in cocaine‐induced behaviors.
Microcephalic osteodysplastic primordial dwarfism type I with biallelic mutations in the RNU4ATAC gene
Authors: Nagy R , Wang H , Albrecht B , Wieczorek D , Gillessen‐ Kaesbach G , Haan E , Meinecke P , de la Chapelle A , Westman JA 
Published: August 2011

Nagy R, Wang H, Albrecht B, Wieczorek D, Gillessen‐Kaesbach G, Haan E, Meinecke P, de la Chapelle A, Westman JA. Microcephalic osteodysplastic primordial dwarfism type I with biallelic mutations in the RNU4ATAC gene.Microcephalic osteodysplastic primordial dwarfism type I (MOPD I) is a rare autosomal recessive developmental disorder characterized by extreme intrauterine growth retardation, severe microcephaly, central nervous system abnormalities, dysmorphic facial features, skin abnormalities, skeletal changes, limb deformations, and early death. Recently, mutations in the RNU4ATAC gene, which encodes U4atac, a small nuclear RNA that is a crucial component of the minor spliceosome, were found to cause MOPD I. MOPD I is the first disease known to be associated with a defect in small nuclear RNAs. We describe here the clinical and molecular data for 17 cases of MOPD I, including 15 previously unreported cases, all carrying biallelic mutations in the RNU4ATAC gene.
Living with haemodialysis: The experience of adolescents in Turkey
Authors: Başkale Hatice , Başer Günsel 
Published: July 2011

Başkale H, Başer G. International Journal of Nursing Practice 2011; 17: 419–427 Living with haemodialysis: The experience of adolescents in Turkey This study explored how adolescents receiving haemodialysis for end‐stage renal disease were affected by their diagnosis and treatment. A qualitative approach was used, with data collected through individual interviews with 18 adolescents aged 12–20. Data were analysed using content analysis method. Adolescents reported physical, psychological and social problems. Compliance related to diet and fluid restrictions were issues for the adolescents interviewed. Body image problems related to physical limitations and the fistula were described. Their regular school attendance was reduced by the illness and therapy, as were socialization and peer interactions. Adolescents felt different from their friends/peers and had negative feelings about their future. Nurses need to assess each adolescent to determine their responses and take action to assist the adolescents with the many issues they are likely to experience. Parents and siblings, who contribute significantly to the care of adolescents on haemodialysis, also require support.
Respecting dignity in care in diverse care settings: Strategies of UK nurses
Authors: Baillie Lesley , Gallagher Ann 
Published: July 2011

Baillie L, Gallagher A. International Journal of Nursing Practice 2011; 17: 336–341 Respecting dignity in care in diverse care settings: Strategies of UK nurses This paper presents nurses' views of dignity issues in diverse UK health‐care settings. A qualitative multisite case study was conducted at seven organizations: four National Health Service hospitals, two independent care providers and one mental health‐care provider. The paper reports on the data from qualitative semistructured interviews (n = 51); the participants worked in a wide variety of care contexts. The data were analysed thematically and this paper reports on the theme ‘strategies to respect dignity in care’. The subthemes were: recognizing vulnerability to dignity loss; enhancing privacy; improving communication between staff and patients/families and building relationships; improving the care environment; and addressing issues that matter to individuals. The findings indicate core elements to promoting dignity that apply across all care settings but suggest that nurses should identify and address dignity issues specific to their own practice areas
How has liberation theology influenced my practice?
Authors: Chan Zenobia CY 
Published: July 2011

Chan ZCY.International Journal of Nursing Practice2011;17: 330–335How has liberation theology influenced my practice?In this paper, I would like to share with readers some concepts from liberation theology in relation to Christian nursing. First, I present liberation theology to explore its concepts and how they can shed light on Christian nursing. I introduce liberation theology and discuss the three concepts of relevance to Christian nursing: emancipatory knowing, contextual mindedness and socioeconomic inequality. Two case studies will be described to revisit the importance of building a rapport, learning the patient's story in a humble and respectful way, and addressing the social inequality and heath disparity of which we should be aware in a patient–nurse encounter. The possibility for collaboration between theologians and Christian nurses should be further explored in the future.
Examination of current handover practice: Evidence to support changing the ritual
Authors: Kerr Debra , Lu Sai , McKinlay Louise , Fuller Christine 
Published: July 2011

Kerr D, Lu S, McKinlay L, Fuller C. International Journal of Nursing Practice 2011; 17: 342–350 Examination of current handover practice: Evidence to support changing the ritual Examining systems of nursing handover provides the opportunity to identify areas in need of improvement and modification. The aim of this study was to describe nursing handover practices for one organization and explore clinical nurses' opinions regarding the quality of the current shift‐to‐shift handover style. One hundred and fifty‐three registered nurses employed in 23 wards in an acute tertiary hospital in Australia completed a survey. The survey collected information about demographic data, current methods and preferences for style of handover and opinions about the quality of nursing handover. This study found that existing handover practice is time‐consuming, lacks patient involvement and essential information, and is varied in style. Only one ward (4.3%) conducted handover at the bedside. The majority (82%) expressed reluctance to change their current handover style. Modification of existing nursing handover is needed but might be challenging in view of the reluctance to change this ritual.
Causes of illness—Constraining and facilitating beliefs
Authors: Järemo Pirjo , Arman Maria 
Published: July 2011

Järemo P, Arman M. International Journal of Nursing Practice 2011; 17: 370–379 Causes of illness—Constraining and facilitating beliefs The aim of this study was to enhance knowledge about patients' beliefs related to different kinds of illnesses and to describe and understand their beliefs as they relate to their outlook on their illnesses. Fifty‐two patients with various illness symptoms receiving integrative anthroposophic care answered an item in a questionnaire about their own thinking of the causes of their illness. The method used for analysis was qualitative content analysis. The result showed that from a patient's perspective a complex combination of causes led to illness. The most prominent causes were psychosocial factors, but personal attitudes, biological factors and chance were also mentioned. Beliefs act as either facilitating or constraining. The informants displayed more constraining than facilitating beliefs, which might prevent them from improving their health. Furthermore, the informants might improve their ability to deal with their illness by identifying their own personal internal resources.
Hand hygiene compliance of nurses: A 5‐unit observational study in North‐Eastern Anatolia
Authors: Polat Sevinç , Parlak Gürol Ayşe , Çevik Ümran 
Published: July 2011

Polat S, Parlak Gürol A, Çevik Ü. International Journal of Nursing Practice 2011; 17: 435–440 Hand hygiene compliance of nurses: A 5‐unit observational study in North‐Eastern Anatolia In five neonatal intensive care units (NICUs) in two cities, the hand hygiene applications of 72 nurses included in this observational study have been investigated. The research was conducted between February and June 2007. It was found that before entering the NICUs, majority of nurses have washed their hands but used much less alcohol‐based antiseptics; more than half of the nurses did not use gloves, and 50 of them did not wash their hands before care and one‐third of the nurses did not wash their hands after care after neonatal treatments. The results obtained from our research showed that most of the nurses paid more attention to hand washing before applying medical treatment.
New treatment for faecal incontinence using zinc–aluminium ointment: a double‐blind randomized trial
Authors: Pinedo G. , Zarate A. J. , Inostroza G. , Meneses X. , Falloux E. , Molina O. , Molina M. E. , Bellolio F. , Zúñiga A. 
Published: July 2011

AbstractAim  In a randomized double‐blind study the therapeutic effect of a novel zinc–aluminium ointment was compared with placebo in patients with faecal incontinence.Method  A randomized double‐blind trial was performed. Patients who met the inclusion criteria were randomized to receive the ointment or a placebo. All were evaluated prior to and 3 weeks after ointment application, using the Wexner incontinence score and the Fecal Incontinence Quality of Life (FIQL) score.Results  Fifty patients were randomized and six were lost to follow‐up, leaving 24 in the treatment and 20 in the placebo group. The average ages were 61.3 and 60.7 years. The respective Wexner scores prior to intervention were 16.6 and 16.7. They decreased significantly after treatment to 8.5 and 13.1 (P < 0.001 and P = 0.002 respectively). There was a significant difference in the final scores, favouring the treatment group (P = 0.001). The FIQL scores for the treatment group were also significantly better in all parameters compared with those of the placebo group.Conclusion  The study shows that the zinc–aluminium based ointment decreases faecal incontinence significantly compared with placebo.
Emergent Transnational Spaces: Meat, Sweat and Global (Re)Production in the Heartland
Authors: MIRAFTAB FARANAK 
Published: July 2011

AbstractThis article asks whether locality and the varied resources, networks and racialized histories of local actors make a difference in the experience of immigrants and their transnational practices. Such questions are typically explored in metropolitan centers and global cities, but the present work results from an ethnographic study of a previously all‐white rural Illinois town, where the meat processing industry recruited a labor force translocally among Latin Americans and West Africans. The article reports on the experience of this rapidly diversifying town where both formal politics and the liberal‐democratic channels of citizens' participation in governance remain exclusionary. Despite this, the diverse immigrant populations have achieved a certain inclusion in public institutions and public spaces. Paying attention to the dynamics developing across immigrant groups through everyday spaces of interaction within their residential community, I argue that the kinds of mediating spaces local context offers are critical to the ability of diverse immigrant groups to renegotiate the interracial social and spatial relations they encounter in a highly contested and constrained context where a global corporation is the sole local employer.RésuméCet article s'interroge sur le fait que la nature locale et la diversité des ressources, réseaux et histoires racialisées des acteurs locaux puissent différencier l'expérience des immigrants et leurs pratiques transnationales. Généralement, ces questions portent sur des centres métropolitains ou des villes mondiales, mais ce travail s'appuie sur l'étude ethnographique d'une ville rurale de l'Illinois dont la population était auparavant entièrement blanche et où le secteur de la transformation de viande a choisi un recrutement translocal de main‐d'œuvre latino‐américaine et ouest‐africaine. L'expérience de cette ville qui a connu une rapide diversification montre que les politiques officielles, de même que les canaux libéral‐démocrates de participation citoyenne à la gouvernance, entretiennent l'exclusion. Les diverses populations immigrantes sont néanmoins parvenues à une certaine inclusion dans les institutions et les espaces publics. En étudiant les dynamiques qui se créent entre les groupes d'immigrants grâce aux espaces d'interaction quotidiens de leur communauté d'habitation, on peut avancer que les types d'espaces de médiation qu'offre le contexte local sont indispensables pour que des groupes d'immigrants différents puissent renégocier les relations sociales et spatiales interraciales propres à un cadre disputé et contraint où le seul employeur local est une entreprise mondialisée.