bluuebunny/crossref_metadata_2025_split huggingface dataset:
FC03-02 - Deep Brain Stimulation of the Nucleus Accumbens in Treatment Resistant Alcohol Addiction - a Novel Treatment Option?
Authors: Mueller U. , Voges J. , Galazky I. , Heldmann M. , Heinze H.-J. , Sturm V. , Bogerts B. 
Published: June 2010

IntroductionTreatment of alcohol addiction remains challenging, since only half of all patients achieve long-term abstinence by currently available therapies.ObjectiveIn the last 2 years, there have been promising reports on deep brain stimulation (DBS) of NAc in addiction (animal models, one case report of a patient with severe anxiety disorder and secondary addiction). Our group treated 5 patients with treatment resistant alcohol addiction with DBS so far. Our initial data of the first 3 patients has just been published. However, these very positive results arise from a continuous open stimulation and have not been placebo controlled.AimsTo assess the impact of discontinuation of bilateral DBS of the NAc on craving for alcohol in patients whose addiction remitted after initiation of DBS.MethodsCrossover, double-blinded phase of 2 × 4 weeks with sham-stimulation in one and stimulation in the other 4 weeks.ResultsUntil now, one patient finished the 8 weeks of study (remaining patients will finish experiment in December 2009). In this patient, stimulation was continued in the first and stopped in the latter 4 weeks. While he experienced no changes or side effects in the first part, he showed a massive craving for alcohol one day after discontinuation, which again remitted when the experiment was stopped and the stimulator was turned on again after 3 days.ConclusionsDBS of NAc seems to selectively alleviate craving for alcohol thus enabling patients to remain abstinent. These results justify clinical studies in larger samples of patients with treatment resistant alcohol addiction.
YSFC01-02 - Preliminary Validation of the Arabic Version of the Behavioral and Emotional Rating Scale
Authors: Almutairi H. 
Published: June 2010

In correspondence to the call for moving beyond symptoms reduction to helping children reach their potentials, Epstein and Sharma (1998) have developed the Behavioral and Emotional Rating Scale (BERS), consisting OF 52 items, taping several area of strengths.This study attempted to ascertain the factor structure as well as the psychometric properties of this instrument in a non-western country, namely, the State of Kuwait.A stratified probability sample was drawn from private and public schools in all counties. A trained coordinators administered the Arabic versions of BERS- parent form (the scale under investigation) and the Strengths and Difficulties Questionnaire (SDQ), developed by Goodman (1997).Results were encouraging and speak to the sound psychometric properties of the Arabic version of BERS. With respect reliability, the overall reliability was excellent (Alpha= .903). By retaining items with factor loading of .50 and above, 28 items were retained with a factorial structure consisting of six components, partially different from the original five-factor solution. Coefficients pertaining to CFA, namely, RMR and GFI indicated a good model fit. Finally, the total strength index of BERS correlated significantly with SDQ and its subscales.Unlike the original form, the resultant 28-item scale is more consistent with recent calls for use of shorter form of scales (Rapid Assessment Instruments, RAI). The six areas of strengths are very conducive in terms of planning interventions and evaluating outcomes. Differences in the extracted latent variables in both versions will be discussed from theoretical as well as cultural points of view.
YSFC01-03 - Young Patients Admitted to an Italian Acute Psychiatry Unit: a Case-Control Study
Authors: Bonafede R. , Tomassi S. , Moretti F. , Pedrini E. , De Ronchi D. , Atti A.R. 
Published: June 2010

ObjectivesTo describe the main features of the younger group of patients hospitalized (January 1st and December 31st) in the Acute Psychiatry Unit of a General Hospital in Bologna (Northern Italy), comparing their socio-demographic and clinical characteristics and their needs with those of the adult patients admitted.MethodsRetrospective consultation of case-histories concerning 111 subjects (60.4% men) randomly selected. Chi-square and independent sample T-test used to compare 33 cases (≤21 years) and 78 controls (35-49 years).ResultsYoung-cases had a higher prevalence of parental separation (31% vs 2.7%; p< 0.001) and were more frequently adopted (18.8% vs 0%; p=0.01). Psychomotor agitation or etero/self-aggressiveness (36.4%) and personality disorders (12.1%) were the most prevalent causes of hospitalization among the younger group, whereas psychosis (32.1%), mood disorders (19.2%) and alcohol-substances dependence (11.5%) were more common in controls (p< 0.001). Presence of unfavorable life-events was two-fold higher in cases than in controls (p=0.074). In particular, quarrels with family (40%) or friends (20%) and substance abuse (13.3%) occurred especially in young individuals. In adults, mournings/separations and rejection therapy were more frequent (p=0.017).Hospitalization's features (type, length, number of laboratory and instrumental exams) were not significantly different among the two groups, except for frequency and number of interviews and childpsychiatrists and educators’ care provided that prevailed in cases.ConclusionsThe young population admitted in our acute psychiatric ward has a complex sociorelational and clinical situation requiring a multi-professional management. The frequent need of care in emergent/urgent situation highlights the importance of further studies on this issue.
YSFC01-05 - Risk Factors of Deliberate Self-Harm Behavior Among Psychiatric Hospitalized Adolescents
Authors: Butwicka A. , Lewandowska A. , Gmitrowicz A. 
Published: June 2010

ObjectivesTo investigate the risk factors of self-harm behavior in Polish adolescents.MethodsPatients hospitalized in Adolescent Psychiatric Clinic during a 4-year period were surveyed by attending psychiatrists. The survey contained categories such as: demographic data, familial, social and school problems, history of violent experience, and mental disorders. Stepwise logistic regression was used to evaluate predictors of self-harm behavior.ResultsOut of 611 (362 females and 249 males, mean age 16.1±1.5 years) adolescents who participated in the study, 261 (42.7%) patients admitted to deliberate self-harm behavior by having attempted suicide. Patients with a diagnosis of behavioral or emotional disorders were more prone to selfharm behavior (p< 0.001). Risk factors retained in the final regression model were: female gender, diagnosis of behavioral disorders, skipping classes, romantic disappointment, sexual abuse and family conflicts (table).ConclusionsActs of deliberate self-harm in adolescence are due to an accumulation of several factors. School-based programs focused on dealing with psychosocial stressors may be considered a feasible means of self-harm prevention.
P01-01 - What are the Newer Option for Treating Acute Bipolar Depression
Authors: Acharya A. 
Published: June 2010

IntroductionBipoler Depression in it's acute psase is a very distressing state for the suffering patient & a chalanging job for the Psychaitrist to treat to alliavete in a reasonable period of time.In acute state Bipolar patients, mostly women in their middle age, moderately overweigted often presents with a crying state or even with potent suicidal ideation that continiue to go on inspite of treatment with pharmacological treatments.AimsHere is an attempt to search for a remedy to these set of patients.Methods72 acutely ill Bipolar depressed patient were assigned with 3 treatment regimens, after their diagnosis was confirmed on the criteria of DSM-4 TR.There age group were 46 to58 years with a median age 52 years. There were 12 Ist episode depressive phase and 60 patients both male 24 & women 36 are recurent sufferers.The Study was conducted in the O.P.D patiends attending Calcutta Pavlov Hospital during 2008-09.1st. group receive only Fluoxotine & olanzapin combination for 6 weeks.2nd group recieve FLuox+Olanzapin +lithium carbonate in 900 mg/day dose.3rd group recieve Lith. carobonate+Olz.+fluoxotine +Lamotrigine in 25-50mg/d.The 1st group with a combo of olanzapin+Fluoxotine were the least responsive.They were evaluated in the Psychologist table usinng ASPER-Montigegmy Depression rating scale.ResultsAllthe groups shows improvement in different items of the scale.3rd group using a tripple drug Combo therapy do the best.ConclusionsIs a poly combo drug therapy or E.C.T or +Psychotherapy combo a best answeer to these criticaly depressed BPD patients.
P01-06 - Bipolar Depression of the II type: Psychopathology, Therapy
Authors: Antokhin E. , Bardyurkina V. , Budza V. , Kryukova E. , Baldina O. 
Published: June 2010

50 patients with difficult depressive episode without psychotic symptoms were examined: 25 in the structure of bipolar depression of the II type (BD), 25 recurrent depression (RD).MethodsClinico-psychopathological with the data verification to SCL-90-R, statistic - Mann-Whitney U-test, Spearmen Rank Order Correlations, Wilcoxon Matched Pairs test. Among patients BD, as opposed to the patients RD, the stronger direct correlation interconnection of “depression” and “somatization”, “obsessivness” is defined (r 0,62-0,81). Compared indications of depression level and basical “index of symptoms’ evidence” (p>0,05) in droups, the patients BD as opposed to the patients RD at p< 0,05 the indications of “anxiety” (2,08&1,67), “somatization” (1,97&1,68), “obsessivness” (1,76&1,4) are higher. These data may show the “residual manic equivalent” in the form of somatization, obsessivness symptoms in the structure of the BD depression, its atypical type and differential - diagnostic symptoms with depression in RD structure is identified. The effectiveness of hospital complex therapy of BD patients is estimated. During 56 days the patients got Seroquel therapy in a dose 150-600 mg/day, group behavioral therapy, sociotherapy. Up to the 10th day of the treatment the indications of “anxiety” (p< 0,05), “depression” (p< 0,05), up to 14th day “somatization” (p< 0,05), up to 21st day “obsessivness” (p< 0,05) were reduced. After hospital complex therapy patients got supporting Seroquel therapy in a dose 50-200 mg/day. In catamnesis in 6 months 11 patients were examined, their state was defined as “stably positive”. These data indicate that the complex therapy of bipolar depression of the II type patients, including Seroquel is effective.
P01-07 - Duloxetine-first Therapeutic Option for Depression with Pain
Authors: Baloescu A. , Vochescu C. 
Published: June 2010

ObjectiveThe purpose of this study was to evaluate the antidepressant duloxetine in depressive patients with pain.MethodThe sample: 28 patients (18 female and 10 male, mean age 53,85) were diagnosed with major depressive disorder (MDD) according to ICD 10. They were assessed with HAMD17 items in baseline and at 14, 28, 42, 56 days, CGIS at baseline, 28 and 56 days, CGII at 28 and 56 day.ResultsPatients received duloxetine (Cymbalta) 60-120 mg/day. All treated patients had a good evolution with a significant improvement on HAMD score. Total score HAMD 17 items was: baseline - 21,9; 14 days - 19,9; 28 days - 17,1; 42 days - 13,1; 56 days - 11,6. At item 13 -diffuse muscle aches in arms or legs the mean score was 1,65 at baseline, and 0,75 at 56 days. The evolution of CGIS was: mean 4,2 in baseline and 1,9 at 56 days. Significant improvement was noted at 56 days: 13/28 (46,42%) were much improved and 15/28 (53,58%) were very much improved. We noted mild nausea at 10 patients, mild restlessness at 7 patients, mild dizziness at 5 patients at the beginning of the treatment.Conclusions1)Our results suggest that duloxetine is a safe and effective treatment for depression.2)The concomitant action for different aches is very important for depressive patients with pain.3)Coexistence of depression with physical pain negatively affects the performance in daily activity and quality of life; in such cases the first treatment option could be duloxetine.
P01-08 - Mania, Mania with Delirium and Delirious Mania
Authors: Barahona-Corrêa B. , Fernandes J. , Alves da Silva J. , Neto B. , Almeida J. 
Published: June 2010

Since Bell's original description delirious mania (DM) has been repeatedly rediscovered and renamed, resulting in much confusion as to its meaning.Definitions range from mania with self-limited temporal-spatial disorientation to a fatal, delirious catatonic syndrome with euphoric mood, high fever and autonomic instability. Moreover, it remains unclear whether DM is a specific clinical entity or an unspecific, unpredictable complication of mania, and whether it is a useful diagnostic category.ObjectiveTo identify the frequency and clinical features of DM and mania with delirium.MethodsWe reviewed all admissions to our acute inpatient unit with mania, hypomania or mixed affective state, in 2006 and 2007. Cases with delirious features and cases with a working diagnosis of DM, were reviewed in detail. The three groups (no delirium, delirious features and DM) were compared for general demographic and clinical variables, as well as features specifically associated with DM (e.g., catatonia; nakedness; inappropriate toileting; unexplained fever, etc).ResultsWe found 100 patients with mania, hippomania or mixed affective state. 14 had medically unexplained delirium, 4 of them with a final diagnosis of DM. DM cases (but not non-DM mania cases with delirious features) had extremely long durations of stay, acute onset, hypertermia, catatonia, autonomic instability, anarchic sleep, shouting/coprolalia, delirium persisting for over a week, and were more likely to receive ECT. Moreover, in three of them DM occurred in most manic/mixed affective episodes.ConclusionDM is a rare occurrence in bipolar disorder. It has typical clinical features and may be recurrent.
P01-09 - Antidepressant Monotherapy and Combination of Antidepressants in the Treatment of Resistant Depression in Current Clinical Practice. A Retrospective Study
Authors: Bares M. , Novak T. , Kopecek M. , Stopkova P. 
Published: June 2010

Introduction and objectivesResistant depression is a long-term, disabling illness. The aim of this study was to compare the efficacy of antidepressant monotherapy (ADM) and combinations of antidepressants (CAD) in the treatment of resistant patient (≥1 unsuccessful antidepressant treatment) in current clinical practice.MethodsWe reviewed chart documents of resistant patients hospitalized at Prague Psychiatric Center for major depressive disorder (DSM IV) and had finished at least 4 - weeks of treatment with ADM or CAD. Clinical status was assessed using MADRS, CGI and BDI-S at baseline, after 2 weeks and in the end of treatment in the framework of regular evaluation during the hospitalization. Response to treatment was defined as a reduction of MADRS score ≥ 50%.Results: We analyzed 78 inpatients (CAD=27, ADM=51). Both groups were equal in baseline characteristics (number of previous treatments, severity of depression etc.) and in the length of index treatment. The CAD group was superior to ADM group in the MADRS score reduction (14.6 vs 10.2 pts, p=0.02) and the proportion of responders (67% vs. 39%, p=0.03) in the end of treatment. The post-hoc effect size of CAD compared to ADM was moderate (Cohen's d=0.54).Conclusion: The results of this study suggest that combinations of antidepressants may be more effective than a monotherapy in patients with resistant depression.This study was supported by a grants from Internal Grant Agency of Ministry of Health of Czech Republic No. NS 10368-3 and a grant from Ministry of Health of Czech Republic MZ0PCP2005.
P01-104 - Association between Obesity, Central Obesity and Depression in Greek type 2 Diabetic Patients
Authors: Tsirogianni E. , Kouniakis F. , Baltatzi M. , Lavrentiadis G. , Alevizos M. 
Published: June 2010

ObjectivesTo estimate the association between obesity, central obesity and depression in a population sample of Greek type 2 diabetic patients.MethodsA total of 200 patients with type 2 diabetes were enrolled in the study. They were stratified according to sex, obesity and central obesity (BMI≥30 Kgr/m2, waist>102cm in men and >88cm in women). Beck Depression Inventory II scale was used to establish the presence of a depressive disorder (DD).ResultsThe frequency of DD among the whole population was 31.5% (34.6% for the female vs. 26% for the male patients, p=0.207). BMI was statistically significant increased in depressive diabetic patients compared to non depressive diabetics, in the total (p=0.003), in women (p=0.013), but not in men (p=0.200). In addition, DD rates were statistically significant increased in diabetic patients with central obesity compared to those without central obesity, in the total (p=0.011) and in men (p=0.014). In female diabetic patients, DD was not related to central obesity (p=0.489).ConclusionsOur data support a strong association between type 2 diabetes and depression in Greek patients. A significant association between obesity and depression is also observed in type 2 diabetic patients. Increased BMI is strongly related to depressive type 2 diabetic women, while central obesity is more related to depressive type 2 diabetic men.
P01-110 - A Naturalistic Trial in Germany with Escitalopram in Depressed Outpatients aged at Least 65 Years
Authors: Flürenbrock W. 
Published: June 2010

ObjectiveTo assess the efficacy and tolerability profile of treatment with escitalopram under naturalistic conditions, in elderly outpatients (≥65 years and above) with depression.Methods2050 patients completed 8 weeks of treatment with escitalopram in a multi-centre naturalistic study. Rating scales included a short version of the Montgomery-Åsberg Depression Rating Scale (svMADRS) for the assessment of response.ResultsMost patients improved in their general state of health and showed a decrease in the severity of their depression. The majority (83.8%) of patients received 10mg/day escitalopram. The mean svMADRS total score decreased from 31.9 (SD=7.9) at baseline to 14.2 (SD=8.5) at Week 8. On completion, 63.9% of the patients were responders (≥50% decrease of svMADRS from baseline) and 48.6% were remitters (svMADRS≤12). Statistically significant more patients aged ≤75 years responded to treatment and achieved remission than those aged >75 years. Logistic regression was used to model response to treatment. Statistically significant positive factors were having a current episode of less than 1 month and duration of illness of less than 1 year. The diagnosis showed increasing responder rates from affective disorder (F31 or F34; odds ratio=1.00) over involutional depression (F03; odds ratio=1.68) and depressive episode (F32; odds ratio=2.21) to recurrent depressive episode (F33; odds ratio=2.32). The differences between affective disorders and involutional depression were significant, while F32 and F33 showed no relevant differences in the responder rates.ConclusionThe results from this observational study corroborate the effectiveness and tolerability of escitalopram treatment of elderly patients in a naturalistic treatment setting.
P01-112 - Affective Temperaments in Epilepsy
Authors: Yazici E. , Yazici A.B. , Aydin N. , Orhan A. , Kirpinar I. 
Published: June 2010

ObjectiveAffective temperaments (AT) are suggested as antecedents of mood disorders (MD) currently. MD especially depression is very common in epilepsy. In this study we investigated AT in epilepsy as probable predictors of MD.Methods83 epileptic patients and 83 healthy controls were included and evaluated using the Temperament Evaluation of Memphis, Pisa, Paris and San Diego-Autoquestionnaire version (TEMPS-A) and SCID-I.ResultsIn epilepsy group 16 depressive, 3 cyclotimic, 12 irritable, 9 anxious temperaments; in healthy group 4 depressive, 3 irritable, 4 anxious temperaments were diagnosed. The difference was significant in depressive (x2: 8.36, p< 0.05) and irritable temperament (x2: 6.06, p< 0.05). Depressive, cyclotimic, irritable, anxious temperaments mean scores were significantly higher in epilepstics (depressive 8.35±4,37; cyclotimic 9,86± 4,67; irritable 7,00±4,58; anxious 9,18±5,94) than healthy controls (depressive 5,89±3,68; cyclotimic 6,87±4,55; irritable 3,39±3,57; anxious 5,11±4,78) (all p< 0,001). 16 patients in epilepsy group and 6 patients in control group were diagnosed as Major Depressive Disorder (MDD) and the difference was significant (x2: 5,38, p< 0,05). Anxious temperament predicted MDD in epileptics and none of the temperaments were significant predictor of MDD in controls in logistic regression analysis.ConclusionEpileptic patients had higher scores at all AT except hypertimic. Anxious and irritable temperaments were diagnosed more in epileptics and anxious temperament was related with MDD. The tendency of epileptics to MD are known but this is the first study shows tendency of epileptics to AT. Further investigations are needed to explain the etiology and treatment relationship between MD and AT in epilepsy.
P01-113 - Venlafaxine for the Treatment of Depression: a Meta-analysis of Chinese Trials
Authors: Zhang Y. , Kösters M. , Becker T. 
Published: June 2010

ObjectivesChinese trials were rarely included in western meta-analyses. This systematic review investigates the efficacy of venlafaxine in the treatment of major depression (MDD) in Chinese populations.MethodsChinese databases (VIP and CNKI) were searched for blinded randomised clinical trials (RCTs) comparing venlafaxine with any other pharmacotherapy and/or placebo. Quality of included studies was assessed with the Jadad scale. Furthermore, fulfilment of the CONSORT items was recorded. Final mean HAM-D scores and response rates were extracted and combined using a fixed-effects model. Subgroup analyses by drug class were performed to assess further differences.Results23 blinded RCTs were included in the analyses. Six compared venlafaxine with selective serotonin reuptake inhibitors (SSRIs), 15 with tricyclic antidepressants (TCAs) and two with tetracyclic antidepressants. The average Jadad score was 2.7 and on average 55% of all CONSORT items were reported. On average, 36 patients were randomised per group. Only three trials included more than 80 patients per group.Mean final HAMD scores were significantly lower in the venlafaxine groups compared to TCA (Hedges’ g 0.14, 95%-CI, 0.01-0.26), but not in comparison to SSRI treated groups (Hedges’ g 0.05, 95%-CI, -0.12-0.21). These findings were confirmed by analyses of response rates. (MH RR Ven vs. TCA: 1.11, 95%-CI, 1.04-1.18, Ven vs. SSRI: 1.01, 95%-CI, 0.93-1.11).ConclusionsThese results suggest that venlafaxine is significantly more effective than TCAs, but not than SSRIs in depressive Chinese populations. However, large high quality trials are needed to verify these findings.