bluuebunny/crossref_metadata_2025_split huggingface dataset:
Perancangan Video Sebagai Media Promosi Pada Restoran Gubug Makan Mang Engking Citra Raya
Authors: Abdul Baqi Muhamad Puad , . Mayasari , Fadilla Rosmawati Mariza 
Published: June 2024

Penelitian ini mengarah pada perancangan video sebagai media promosi yang efektif untuk menarik perhatian calon pelanggan untuk datang dan menikmati berbagai hidangan di restoran Gubug Makan Mang Engking Citra Raya. Metode penelitian yang digunakan yaitu Metode Pengumpuan Data melalui Observasi, Wawancara, dan Studi Pustaka, Metode Anaisis SWOT, Metode Konsep Perancangan Media (KPM) dengan menggunakan software Adobe Premiere Pro 2020 dan Adobe After Effects 2020 yang didalamnya terdapat tahapan Pra-Produksi, tahapan Produksi, dan tahapan Pasca Produksi. Hasil dari perancangan video ini adalah memberikan informasi yang lebih lengkap, menarik dan lebih update dengan menggunakan elemen audio visual, music, dan efek visual yang membuat video promosi ini menjadi sangat menarik, sehingga dapat mendapat perhatian pelanggan dan khalayak serta relasi untuk mencari tahu lebih lanjut, mengunjungi, dan bahkan mengadakan acara/event di Gubug Makan Mang Engking Citra Raya dengan menampilkan profil, pelayanan, fasililtas, keunggulan, produk makanan dan minuman beserta harga, acara (event), juga testimony dari beberapa pengunjung, serta kata promosi, yang nantinya dapat diimplementasikan melalui channel youtube dan social media yang dimiliki. kemudian dapat lebih meningkatkan jumlah relasi, pelanggan yang datang berkunjung maupun mengadakan acara/event dan meningkatkan jumlah omset pada setiap tahunnya, serta lebih dikenal oleh masyarakat luas.
Potential Usefulness of IgA for the Early Detection of SARS-CoV-2 Infection: Comparison With IgM
Authors: Wang Pei 
Published: June 2024

Abstract
Serological testing can be a powerful complementary approach to achieve timely diagnosis of severe acute respiratory coronavirus 2 (SARS-CoV-2) infection, along with nucleic acid detection. Immunoglobulin (Ig) A antibodies are less frequently utilized to detect SARS-CoV-2 infection than IgM and IgG antibodies, even though IgA antibodies play an important role in protective immunity against SARS-CoV-2. This review discusses the differences in kinetics and assay performance between IgA and IgM antibodies and the factors influencing antibody responses. It highlights the potential usefulness of analyzing IgA antibodies for the early detection of SARS-CoV-2 infection. The early appearance of IgA and the high sensitivity of IgA-based immunoassays can aid in diagnosing coronavirus disease 2019. However, because of cross-reactivity, it is important to recognize the only moderate specificity of the early detection of SARS-CoV-2 IgA antibodies against spike antigens. Either the analysis of antibodies targeting the nucleocapsid antigen or a combination of antibodies against the nucleocapsid and spike antigens may strengthen the accuracy of serological evaluation.
LIFE CYCLE OF BRAZILIAN CITIES
Authors: Théry Hervé Théry 
Published: June 2024

As cidades brasileiras costumam ter o ciclo completo de nascimento, crescimento, declínio – e às vezes desaparecimento ou recuperação – em curtos períodos de tempo, às vezes menos de um século. O texto analisa várias situações, Londrina (Paraná), fundada em 1929, Sinop (Mato Grosso), fundada em 1974, Ouro Preto (Minas Gerais), de 1711 e Paraty (Rio de Janeiro), de 1597. Dentre a criação de capitais de estados, escolhemos os exemplos de Belo Horizonte (1897) e Palmas (1989) e, no âmbito nacional, o caso de Brasília (Distrito Federal), fundada em 1960.

Palavras-chave: Ciclo de vida. Cidades brasileiras. Fundação, crescimento, declínio.
EVALUASI KESESUAIAN LAHAN TANAMAN JAGUNG (Zea mays L.) DI KECAMATAN BONTONOMPO SELATAN KABUPATEN GOWA
Authors: Suryawijaya Ade Indra , Ibrahim Baktiar , Robbo Anwar , Tjoneng Amir 
Published: June 2024

This study aims to determine the actual, potential and limiting factors of corn (Zea mays L.) land suitability in South Bontonompo District, Gowa Regency. The method used in this research is survey method and descriptive data analysis and determination of land suitability class based on FAO method. The results of actual land suitability of corn crops in land units 1,2,3 and 4 in South Bontonompo District are marginally suitable (S3), while potential land suitability is very suitable (S1). Factors limiting actual land suitability are available nutrients (total N and P205). Efforts made for productivity by applying urea and P-36 fertiliser.
Demographic Analysis of Active Transport Mode Users in Urban Context
Authors: Jaber Ahmed , Hamadneh Jamil 
Published: June 2024

Active transportation, such as walking, cycling, and micro-mobility modes, has received a lot of attention in recent years due to its potential benefits to urban residents, such as less traffic, better air quality, more opportunities to get exercise, and an overall higher quality of life. In this study, we used Classification and Regression Trees (CART) to compare and contrast three mobility options: shared micro-mobility, private micro-mobility, and walking. We surveyed 219 people living in Budapest, Hungary, to learn more about their travel habits and investigate the demographic elements that influence people's mode choice, such as age, gender, ownership of micro-mobility vehicles, education, job, and income. Results showed that ownership of personal micro-mobility vehicles, and age as important predictors of active travel mode choice. Men seem to consider cost and weather conditions when choosing shared micromobility modes, while women value safety and weather conditions. Our findings can guide policy decisions and urban planning initiatives by identifying the most significant predictors of mode choice and evaluating the possible benefits and drawbacks of each mode.
Biomechanical evaluation of ortho-bridge system and proximal femoral nail antirotation in intertrochanteric fractures with lateral wall fracture based on finite element analysis
Authors: Long Yuntao , Liu Na , Huang Xiaomeng , Liang Weiming , Liu Jianke , Huang Zhaozhao , Zhang Yanhui , Wang Wen 
Published: June 2024

BackgroundThe integrity of the lateral wall in femoral intertrochanteric fractures significantly impacts fracture stability and internal fixation. In this study, we compared the outcomes of treating intertrochanteric fractures with lateral wall involvement using the ortho-bridge system (OBS) combined with proximal femoral nail antirotation (PFNA) versus simple PFNA from a biomechanical perspective.MethodsFinite-element models of femoral intertrochanteric fractures with lateral wall involvement were subjected to fixation with OBS combined with PFNA and simple PFNA. Von Mises stress measurements and corresponding displacement assessments for each component of the model, including the proximal femur and lateral wall, were used to evaluate the biomechanical effects of OBS fixation on bone and intramedullary nail stability.ResultsUsing PFNA alone to fix intertrochanteric fractures with lateral wall involvement resulted in von Mises stress levels on the lateral wall exceeding safe stress tolerances for bone growth. OBS fixation significantly reduced stress on the lateral wall of the femur and minimized the stress on each part of the intramedullary nail, reducing the overall displacement.ConclusionIn cases of intertrochanteric fractures with lateral wall involvement, PFNA fixation alone may compromise the biomechanical integrity of the lateral femoral wall, increasing the risk of postoperative complications. The addition of OBS to PFNA significantly reduces stress on the lateral femoral wall. Consequently, OBS should be considered for lateral wall fixation when managing intertrochanteric fractures combined with lateral wall fractures.
Genomic and phenotypic inconsistencies in Pseudomonas aeruginosa resistome among intensive care patients
Authors: Dolgusevs Mihails , Jain Nityanand , Savicka Oksana , Vangravs Reinis , Bodrenko Jevgenijs , Bergmanis Edvins , Zemite Dace , Selderina Solvita , Reinis Aigars , Rozentale Baiba 
Published: June 2024

ObjectivePseudomonas aeruginosa, a difficult-to-manage nosocomial pathogen, poses a serious threat to clinical outcomes in intensive care (ICU) patients due to its high antimicrobial resistance (AMR). To promote effective management, it is essential to investigate the genomic and phenotypic differences in AMR expression of the isolates.MethodsA prospective observational study was conducted from July 2022 to April 2023 at Liepaja Regional Hospital in Latvia. The study included all adult patients who were admitted to the ICU and had a documented infection with P. aeruginosa, as confirmed by standard laboratory microbiological testing and short-read sequencing. Since ResFinder is the only sequencing-based database offering antibacterial susceptibility testing (AST) data for each antibiotic, we conducted a comparison of the resistance profile with the results of phenotypic testing, evaluating if ResFinder met the US Food and Drug Administration (FDA) requirements for approval as a new AMR diagnostic test. Next, to improve precision, AST data from ResFinder was compared with two other databases – AMRFinderPlus and RGI. Additionally, data was gathered from environmental samples to inform the implementation of appropriate infection control measures in real time.ResultsOur cohort consisted of 33 samples from 29 ICU patients and 34 environmental samples. The presence of P. aeruginosa infection was found to be associated with unfavourable clinical outcomes. A third of the patient samples were identified as multi-drug resistant isolates. Apart from resistance against colistin, significant discrepancies were observed when phenotypic data were compared to genotypic data. For example, the aminoglycoside resistance prediction of ResFinder yielded a major errors value of 3.03% for amikacin, which was marginally above the FDA threshold. Among the three positive environmental samples, one sample exhibited multiple AMR genes similar to the patient samples in its cluster.ConclusionOur findings underscore the importance of utilizing a combination of diagnostic methods for the identification of resistance mechanisms, clusters, and environmental reservoirs in ICUs.
Enhanced immune reconstitution with albuvirtide in HIV-infected immunological non-responders
Authors: Fan Lina , Hu Yue , Li Rui , Ding Jiaqi , Liu Yuantao , Yu Shuchang , Hu Min , Su Rui , Li Yangyang , Yu AiPing , Xie Dong , Zhao Qingxia , Ma Ping 
Published: June 2024

BackgroundIncomplete immune recovery in people living with HIV/AIDS (PLWHA) remains an important clinical challenge with the lack of an effective strategy currently available to restore their T-cell immune response. This study aimed to evaluate the effect of Albuvirtide (ABT) on immune recovery in immunological non-responders (INRs) and attempted to explore potential mechanisms of ABT on the functionality of immune cells.MethodsIn this prospective, open-label, controlled clinical study, participants with incomplete immune reconstitution (continuous ART over 5 years and CD4+T lymphocyte absolute count of &lt;500 cells/µl or ART for 2–5 years and CD4+T cell count of &lt;200 cells/µl with undetectable viral load) were received intensive treatment with ABT or maintained on the original ART regimen at a ratio of 1:1. Immune response and safety were examined within 24 weeks. In the cytological study, T subsets, cell apoptosis and cell autophagy were analyzed using immunofluorescence staining and flow cytometry from 25 blood specimens.ResultsBoth groups (n=25 each) were comparable in age, gender, and ART duration. At week 12, CD4+T cell count increased significantly in the intensive ABT group compared with control group (the change from baseline in CD4+T cell count: 45 vs. -5 cells/µL, p&lt;0.001). After ABT discontinuation, CD4+T cell counts remained significantly higher in the intensive ABT group at week 24 (55 vs. -5 cells/µL, p=0.012). In laboratory analysis, naïve CD4+ T cell amounts were lowest among participants with unsatisfactory immune response (uIR) to ABT (p=0.001). The proportion of caspase 3+CD45RA+CD31+CD4+ T cells was significantly lower in participants with satisfactory immune response (sIR) to ABT (p&lt;0.05).ConclusionSignificant CD4+T cell count increase suggests ABT enhances immune function in INRs which may be attributed to its antiviral properties as well as its ability to increase thymic cell output and decrease cell apoptosis.
Cooperative and competitive learning as transformative factors of educational processes for extracurricular skill enhancement
Authors: Cavaletto Giulia Maria , Miglietta Anna 
Published: June 2024

IntroductionThe learning process goes beyond the acquisition of curricular cognitive elements to include extracurricular skills. This extended concept has attracted renewed attention through the European Council Recommendation (2018) on skills development for lifelong learning in schools. The Organization for Economic Cooperation and Development has also highlighted the relevance of socio-emotional skills for learning and life chances. The official uptake of extracurricular skills in curricula poses schools and educators the challenge of finding ways to conceptualize, teach, and assess them. To this end, co-operative learning and peer-to-peer education hold a prominent place among educational strategies alternative to conventional teaching practices. Both actively engage students and have a positive impact on achievement in curricular disciplines and on the development of lifelong learning skills and social and emotional competences. The present study presents a case study in which collaborative learning was supported via a digital platform.MethodsWe analyzed the qualitative data collected in Italian schools taking part in the Kids4alll, a Horizon 2020 project. The project’s aim is to improve lifelong learning skills directly and other skills indirectly through collaborative learning based on the “buddy method” (pairs or groups of peers working together).Results and discussionOur findings reveal the potential benefit of peer-to-peer approaches. This potential extends to the development of co-operative skills used in school context and transferable to other areas, along with the acquisition of character-building skills. However, a criticality in the application of peer learning interventions is that many teachers are often ill prepared to implement cooperative learning in classroom practice or lack sufficient training in matching peer-to-peer work and pedagogical needs.
Robust evidence supports a causal link between higher birthweight and longer telomere length: a mendelian randomization study
Authors: Zhang Zhuoya , Zhang Jiale , Zhang Kaiqi , Ge Xiaolei , Zhai Xu 
Published: June 2024

BackgroundObservational studies have suggested a potential relationship between birthweight and telomere length. However, the causal link between these two parameters remains undefined. In this study, we use Mendelian Randomization (MR). This method employs genetic variants as instrumental variables, to explore the existence of causal associations and elucidate the causal relationship between birth weight and telomere length.MethodsWe used 35 single nucleotide polymorphisms (SNPs) as instrumental variables for birth weight. These SNPs were identified from a meta-analysis involving 153,781 individuals. Furthermore, we obtained summary statistics for telomere length from a study conducted on 472,174 United Kingdom Biobank participants. To evaluate the causal estimates, we applied the random effect inverse variance weighted method (IVW) and several other MR methods, such as MR-Egger, weighted median, and MR-PRESSO, to verify the reliability of our findings.ResultsOur analysis supports a significant causal relationship between genetically predicted birth weight and telomer3e length. The inverse variance weighted analysis results for birth weight (Beta = 0.048; 95%CI = 0.023 to 0.073; p &lt; 0.001) corroborate this association.ConclusionOur study provides robust evidence supporting a causal link between higher birth weight and longer telomere length.
Endometriosis is a disease of immune dysfunction, which could be linked to microbiota
Authors: Liu Hongyan , Li Junxia , Guan Chenchen , Gao Wenjie , Li Yan , Wang Jianmei , Yang Yang , Du Yongrui 
Published: June 2024

Background: Endometriosis, characterized by extrauterine endometrial tissue, leads to irregular bleeding and pelvic pain. Menstrual retrograde theory suggests fragments traverse fallopian tubes, causing inflammation and scar tissue. Prevalent among infertile women, risk factors include fewer pregnancies, delayed childbirth, irregular cycles, and familial predisposition. Treatments, medication, and surgery entail side effects. Studies link gut microbiota alterations to endometriosis, necessitating research to establish causation. We used Mendelian randomization to investigate the potential link between endometriosis and gut microbiota through genetic variants.Methods: Two-sample Mendelian randomization analyzed gut microbiota’s potential causal effects on endometriosis. Instrumental variables, robustly associated with exposures, leveraged GWAS data from MiBioGen for gut microbiota and FinnGen R8 release for endometriosis. SNPs strongly associated with exposures were instrumental variables. Rigorous assessments ensured SNP impact scrutiny on endometriosis.Results: At the genus level, Anaerotruncus, Desulfovibrio, Haemophilus, and Holdemania showed causal association with endometriosis. Specific gut microbiota exhibited causal effects on different endometriosis stages. Holdemania and Ruminococcaceae UCG002 exerted reversible, stage-specific impacts.Conclusion: Mendelian randomization provides evidence for the causal link between specific gut microbiotas and endometriosis, emphasizing the pivotal role of gut microbiota dysbiosis. Modulating gut microbiota emerges as a promising strategy for preventing and treating endometriosis.
Generation of functionally active resident macrophages from adipose tissue by 3D cultures
Authors: Arlat Adèle , Renoud Marie-Laure , Nakhle Jean , Thomas Miguel , Fontaine Jessica , Arnaud Emmanuelle , Dray Cédric , Authier Hélène , Monsarrat Paul , Coste Agnès , Casteilla Louis , Ousset Marielle , Cousin Béatrice 
Published: June 2024

IntroductionWithin adipose tissue (AT), different macrophage subsets have been described, which played pivotal and specific roles in upholding tissue homeostasis under both physiological and pathological conditions. Nonetheless, studying resident macrophages in-vitro poses challenges, as the isolation process and the culture for extended periods can alter their inherent properties.MethodsStroma-vascular cells isolated from murine subcutaneous AT were seeded on ultra-low adherent plates in the presence of macrophage colony-stimulating factor. After 4 days of culture, the cells spontaneously aggregate to form spheroids. A week later, macrophages begin to spread out of the spheroid and adhere to the culture plate.ResultsThis innovative three-dimensional (3D) culture method enables the generation of functional mature macrophages that present distinct genic and phenotypic characteristics compared to bone marrow–derived macrophages. They also show specific metabolic activity and polarization in response to stimulation, but similar phagocytic capacity. Additionally, based on single-cell analysis, AT-macrophages generated in 3D culture mirror the phenotypic and functional traits of in-vivo AT resident macrophages.DiscussionOur study describes a 3D in-vitro system for generating and culturing functional AT-resident macrophages, without the need for cell sorting. This system thus stands as a valuable resource for exploring the differentiation and function of AT-macrophages in vitro in diverse physiological and pathological contexts.
Systematic review on the implementation of metrological assurance systems for medical devices in Latin America
Authors: Farfán-Vargas Harold M. , Espinoza-Morriberon Dante , Moya-Salazar Marcia M. , Contreras-Pulache Hans , Moya-Salazar Jeel 
Published: June 2024

BackgroundMetrology plays a crucial role in small healthcare service businesses to ensure the quality of products and services. While legal metrology in healthcare exists in some regions, it lacks harmonization. In other countries, there is limited presence of metrology in medical and biomedical engineering. We aimed to evaluate the implementation of metrological assurance systems for medical devices in Latin America.MethodsA systematic review was conducted following PRISMA 2020 guidelines and registered with PROSPERO (CRD42022359284). Searches were performed across 13 databases from October 30th to November 3rd, 2022. The search equation was “(((quality assurance) AND (metrology)) AND (medical devices)).” A total of 7,789 documents were identified, of which only 16 met the inclusion criteria.ResultsThe majority of studies (75%) were conducted in Colombia, with a significant portion being undergraduate theses. The primary normative references used in the analyzed studies were ISO 10012 and ISO 17025, with the majority (68.75%) relying on national legislation for their approach. One study in Colombia referenced eight standards, and one in Brazil analyzed user involvement in medical device management. Among the included studies, 56.25% were conducted in healthcare institutions, mainly clinics. Most studies provided implementation guidelines, with ISO 10012 being prominent, alongside ISO 17025, which implicitly addresses ISO 9001 elements. Global bias was low across all studies.ConclusionOur results underscore the importance of metrological assurance in managing medical devices in Latin America. The utilization of international standards and national legislation illustrates the diverse approaches adopted by different institutions. Future research should focus on optimizing metrological practices to enhance quality and safety in healthcare.
Differential risks of psoriatic arthritis development in patients with varied psoriasis manifestations: a sex- and ethnicity-specific analysis
Authors: Gershater Bernard , Bieber Katja , Vorobyev Artem , Ludwig Marlene A. , Zirpel Henner , De Luca David A. , Thaci Diamant , Kridin Khalaf , Ludwig Ralf J. 
Published: June 2024

ObjectivesThis study investigated psoriatic arthritis (PsA) risk across varied psoriasis manifestations, considering sex and ethnicity.MethodsUsing TriNetX, a federated database encompassing over 120 million electronic health records (EHRs), we performed global retrospective cohort studies. Psoriasis vulgaris (Pso), pustulosis palmoplantaris (PPP), and generalized pustular psoriasis (GPP) cohorts were retrieved using ICD-10 codes. Propensity score matching, incorporating age, sex, and ethnicity, was employed. An alternative propensity matching model additionally included established PsA risk factors.ResultsWe retrieved data from 486 (Black or African American-stratified, GPP) to 35,281 (Pso) EHRs from the US Collaborative Network. Significant PsA risk variations emerged: Pso carried the highest risk [hazard ratio (HR) 87.7, confidence interval (CI) 63.4–121.1, p &lt; 0.001], followed by GPP (HR 26.8, CI 6.5–110.1, p &lt; 0.0001), and PPP (HR 15.3, CI 7.9–29.5, p &lt; 0.0001). Moreover, we identified significant sex- and ethnicity-specific disparities in PsA development. For instance, compared to male Pso patients, female Pso patients had an elevated PsA risk (HR 1.1, CI 1.1–1.2, p = 0.002). Furthermore, White Pso patients had a higher likelihood of developing PsA compared to their Black or African American counterparts (HR 1.3, CI 1.04–1.7, p = 0.0244). We validated key findings using alternative propensity matching strategies and independent databases.ConclusionThis study delineates nuanced PsA risk profiles across psoriasis forms, highlighting the pivotal roles of sex and ethnicity. Integrating these factors into PsA risk assessments enables tailored monitoring and interventions, potentially impacting psoriasis patient care quality.