bluuebunny/crossref_metadata_2025_split huggingface dataset:
Aortic dissection and moyamoya disease in Turner syndrome
Authors: Jagannath Anand D. , Rastogi Ujjwal , Spooner Amy E. , Lin Angela E. , Agnihotri Arvind K. 
Published: July 2010

AbstractAortic dilation and dissection are well‐recognized cardiac abnormalities in women with Turner syndrome (TS), although the underlying pathophysiology is not fully understood. We report on a 46‐year‐old Hispanic woman who was previously diagnosed with moyamoya disease on magnetic resonance imaging after a presentation with stroke‐like symptoms. Her features were consistent with TS and chromosome analysis revealed mosaicism in which 17% of the cells showed a pseudoisodicentric Y chromosome: 45,X (25)/46,X psu idic (Y)(11.2) (5). A preceding screening transthoracic echocardiogram had shown a bicuspid aortic valve (BAV) with an aortic diameter of 3.2 cm; at the time of moyamoya diagnosis, the aorta was 3.5 cm with mild aortic stenosis and mild aortic regurgitation. Four years later, the patient had had an acute aortic dissection, Stanford type A, which was repaired successfully. This case report is the third individual with TS associated with moyamoya disease and the first associated with dissection. The small number of cases does not allow detailed analysis other than noting patient age (two older than 40 years), karyotype (two others associated with isochrome Xq), and associated cardiac risk factors (one with BAV). Although this may be a chance occurrence, we hypothesize that moyamoya disease could be a manifestation of the vasculopathy in TS. © 2010 Wiley‐Liss, Inc.
Arterial rupture in classic Ehlers–Danlos syndrome with COL5A1 mutation
Authors: Borck Guntram , Beighton Peter , Wilhelm Christian , Kohlhase Jürgen , Kubisch Christian 
Published: July 2010

AbstractThe vascular type of Ehlers–Danlos syndrome (EDS IV) is associated with a high risk of life‐threatening medical complications, including ruptures of large arteries, the intestine, and the uterus during pregnancy. An arterial rupture occurring in an individual with EDS is regarded as almost diagnostic of EDS IV, which is caused by heterozygous mutations in COL3A1. Here however, we report on a man with skin lesions typical of EDS, easy bruising and recurrent inguinal hernias who had a spontaneous rupture of the left common iliac artery at the age of 42 years but in whom we detected no COL3A1 mutation. As he clinically fulfilled the diagnostic criteria for classic EDS (EDS I), we sequenced the major EDS I gene COL5A1 and identified a heterozygous de novo nonsense mutation, c.3184C>T (p.R1062X). As, to the best of our knowledge, this is the first report of a patient with COL5A1 mutation‐positive classic EDS and rupture of a large artery, we suggest that arterial rupture might be a rare complication of classic EDS. This finding has potential implications for genetic counseling and molecular genetic testing in Ehlers–Danlos syndrome. © 2010 Wiley‐Liss, Inc.
Fulminant hepatic failure requiring liver transplantation in 22q13.3 deletion syndrome
Authors: Bartsch Oliver , Schneider Eberhard , Damatova Natalja , Weis Roger , Tufano Maria , Iorio Raffaele , Ahmed Alischo , Beyer Vera , Zechner Ulrich , Haaf Thomas 
Published: July 2010

AbstractWe report on a 4‐year‐old girl with severe developmental delay, absent speech, and chromosome 22q13.3 deletion (Phelan–McDermid syndrome), karyotype 46,XX.ish del(22)(q13.31qter)(ARSA‐,N85A‐,SHANK3‐). At the age of 3 years, she needed an emergency liver transplantation because of fulminant hepatic failure, most likely caused by hyperacute autoimmune hepatitis triggered by a viral infection. This is the second report of a patient with 22q13.3 deletion and fulminant liver failure. By array‐CGH we identified in this patient a 5.675 Mb terminal deletion (22q13.31 → qter; including ∼55 genes; from NUP50 to RABL2B) and in the previous patient a 1.535 Mb deletion (22q13.32 → qter; including ∼39 genes; from BRD1 to RABL2B). PIM3 is a prime candidate gene for the fulminant hepatic failure in the two patients; SHANK3/PROSAP2 could be another candidate gene. We recommend liver function tests and array‐CGH in the management of patients with Phelan–McDermid syndrome. This patient showed a developmental catch‐up following the liver transplantation, possibly suggesting that chronic hepatic disease could contribute to the developmental delay in a subset of these patients. © 2010 Wiley‐Liss, Inc.
Reinforcement and antioxidation effects of fullerenol‐containing natural rubber
Authors: Kondo Hiroaki , Ohtake Yoshito 
Published: July 2010

AbstractNatural rubber (NR) containing fullerenol, C60‐OH, was prepared by two methods; one by mixing C60‐OH aqueous solution to NR latex followed by coagulation (wet method) and the other by mixing C60‐OH powder with solid rubber by an open roll mixer (dry method). C60‐OH mixed by wet method was homogeneously dispersed in the rubber, while one mixed by dry method was particles in the size up to 70 μm. The former exhibited large reinforcing and antiaging effect than the latter. The large antiaging effect was explained by the finding that C60‐OH had large radical scavenging ability and gel forming ability during heat treatment. © 2010 Wiley Periodicals, Inc. J Appl Polym Sci, 2010
Preparation of shish‐kebab and nanofiber polyethylene with chromium/Santa Barbara amorphous silica‐15 catalysts
Authors: Ahmadi Ebrahim , Haghighi Mehdi Nekoomanesh , Mohamadnia Zahra , Ramazani Ali 
Published: July 2010

AbstractCr/SBA‐15 catalysts were prepared by the grafting of chromium nitrate nonahydrate [Cr(NO3)3·9H2O] complexes onto SBA‐15 mesoporous materials. Shish‐kebab and nanofiber polyethylenes (PEs) were prepared under different temperatures via ethylene extrusion polymerization with the Cr(NO3)3·9H2O catalytic system. The diameter of a single nanofiber was 100–250 nm. Scanning electron microscopy images showed that the polymer obtained from the SBA‐15‐supported catalyst under different polymerization temperatures produced nanofiber and/or shish‐kebab morphologies. X‐ray diffraction and differential scanning calorimetry were used to characterize microstructures of the materials. Polymers obtained with all of the catalysts showed a melting temperature, bulk density, and high load melt index; this indicated the formation of linear high‐density PE. © 2010 Wiley Periodicals, Inc. J Appl Polym Sci, 2010
Evaluation of serum‐free differentiation conditions for C2C12 myoblast cells assessed as to active tension generation capability
Authors: Fujita Hideaki , Endo Akiko , Shimizu Kazunori , Nagamori Eiji 
Published: July 2010

AbstractWe have compared several serum‐free media for the differentiation of C2C12 myoblasts and assessed the extent of differentiation in several ways including as to active tension generation capability. C2C12 cells were allowed to differentiate in Dulbecco's modified Eagle's medium (DMEM) containing Ham's F‐12 (F‐12), AIM‐V (AIM), 0.2% Ultroser‐G in DMEM (Ult‐G), and 0.1% Sericin in DMEM (Sericin), compared with in DMEM supplemented with 2% horse serum (HS) or 2% calf serum (CS). C2C12 differentiation was assessed as the extent of myotube formation, glucose metabolism, protein expression, sarcomere formation, and active tension generation. All serum‐free media examined were capable of inducing myotube formation and the expression of muscle‐specific proteins. All serum‐free media except for F‐12 gave the sarcomere structure. Active tension generation was observed for cells that differentiated in AIM and Ult‐G, but the active tension generated by C2C12 cells that differentiated in Ult‐G was only ∼25% in the case of myotubes that formed in HS. The addition of Ult‐G to the AIM resulted in improvement of the active tension generation capability, the active tension generated being ∼3.4× compared to that in HS. The approach for assessing muscle cell differentiation presented in this study will be suitable for other studies that involve the differentiation of muscle cells. Biotechnol. Bioeng. 2010;107: 894–901. © 2010 Wiley Periodicals, Inc.
Integrative analysis using proteome and transcriptome data from yeast to unravel regulatory patterns at post‐transcriptional level
Authors: Olivares‐Hernández Roberto , Usaite Renata , Nielsen Jens 
Published: July 2010

AbstractExist several studies on the correlation between proteome and transcriptome and these studies have shown that generally there is only a weak positive correlation between these two omes, which means that post‐transcriptional events play an important role in determining the protein levels in the cell. In this study we combined proteome and transcriptome data from six different published dataset to identify patterns that can provide new insight into the reasons for these deviations. By using a categorization method and integrating genome‐scale information we found that the relation between protein and mRNA is related to the gene function. We could further identify that for genes belonging to amino acid biosynthetic pathways there is no translational regulation, meaning that there is generally a good correlation between mRNA and protein levels. We also found that there is generally translational control for large proteins and there also evidence for a role of conserved motifs in the 3′ untranslated regions in the mRNA‐protein correlation, probably by controlling the level of mRNA. Biotechnol. Bioeng. 2010;107: 865–875. © 2010 Wiley Periodicals, Inc.
Stakeholder engagement and environmental strategy – the case of climate change
Authors: Sprengel David Christopher , Busch Timo 
Published: July 2010

AbstractMany management studies analyze stakeholder pressures and corresponding corporate strategies in the context of the natural environment. This study investigates the role of the sources of stakeholder pressures and additional contextual factors for choosing an environmental strategy. By focusing on climate change as an important ecological challenge, four general response strategies to greenhouse gas (GHG) reduction pressures are empirically derived and discussed. The analysis is based on a global survey that includes 141 companies across eight different GHG emission‐intensive industries. It is found that organizations' response strategies do not relate to individual stakeholder groups, but rather the organization's level of pollution measured as its GHG intensity is identified to have an influence on the environmental strategy. We discuss important implications for stakeholder theory as well as policy makers and suggest areas for future research. Copyright © 2010 John Wiley & Sons, Ltd and ERP Environment.
Synthesis, Structure, DNA‐Binding Properties, and Cytotoxicity of Ruthenium(II) Polypyridyl Complexes
Authors: Liu Yun‐Jun , Zeng Cheng‐Hui , Yao Jun‐Hua , Wu Fu‐Hai , He Li‐Xin , Huang Hong‐Liang 
Published: July 2010

AbstractMany ruthenium(II) complexes show high antitumor activities, and the in vitro antitumor activities are usually related to DNA binding. We designed and synthesized two RuII polypyridyl complexes, [Ru(dmp)2(fpp)]2+ (dmp=2,9‐dimethyl‐1,10‐phenanthroline; fpp=2‐[3,4‐(difluoromethylenedioxy)phenyl]imidazo[4,5‐f] [1,10]phenanthroline and [Ru(phen)2(fpp)]2+ (phen=1,10‐phenanthroline). The DNA‐binding properties of these complexes have been investigated by spectroscopic titration, DNA melting experiments, viscosity measurements, and photoactivated cleavage. The mechanism studies of photocleavage revealed that singlet oxygen (1O2) and superoxide anion radical (O$\rm{{_{2}^{{^\cdot} -}}}$) may play an important role in the photocleavage. The cytotoxicity of complexes 1 and 2 have been evaluated by MTT (3‐(4,5‐dimethylthiazol‐2‐yl)‐2,5‐diphenyl‐2H‐tetrazolium bromide) method; complex 2 shows slightly higher anticancer potency than 1 does against all the cell lines screened.
Secondary Metabolites and Antimycobacterial Activities from the Roots of Ficus nervosa
Authors: Chen Li‐Wen , Cheng Ming‐Jen , Peng Chien‐Fang , Chen Ih‐Sheng 
Published: July 2010

AbstractBioassay‐guided fractionation of the active AcOEt‐soluble layer led to the isolation of two new pyranocoumarins, 3‐hydroxyxanthyletin (1) and 3‐methoxyxanthyletin (2), along with 22 known compounds including four simple coumarins, i.e., xanthyletin (3), umbelliferone (4), scopoletin (5), and (+)‐(S)‐marmesin (6); nine flavonoids, i.e., carpachromene (7), parvisoflavone B (8), alpinumisoflavone (9) genistein (10), 2′‐hydroxygenistein (11), prunetin (12), cajanin (13), apigenin (14), and (2S)‐naringenin (15); three benzenoids, i.e., 4‐hydroxybenzaldehyde (16), vanillin (17), and (S)‐lasiodiplodin (18); five steroids, i.e., ergosterol peroxide (19), a mixture of 6β‐hydroxystigmast‐4‐en‐3‐one (20) and 6β‐hydroxystigmasta‐4,22‐dien‐3‐one (21), and a mixture of β‐sitosterol (22) and stigmasterol (23); and one triterpenoid, i.e., oleanolic acid (24) from the roots of Ficus nervosa. Their structures were elucidated on the basis of extensive 1D‐ and 2D‐NMR as well as MS analyses. Among these isolates, 3‐hydroxyxanthyletin (1), genistein (10), prunetin (12), and (2S)‐naringenin (15) showed antimycobacterial activities against Mycobacterium tuberculosis H37RV in vitro with MIC values of 16, 35, 30, and ≤2.8 μg/ml, respectively.
Trace Metal Contents of Selected Seeds and Vegetables from Oil Producing Areas of Nigeria
Authors: Wegwu Matthew O. , Omeodu Stephen I. 
Published: July 2010

AbstractThe concentrations of accumulated trace metals in selected seeds and vegetables collected in the oil producing Rivers State of Nigeria were investigated. The values were compared with those of seeds and vegetables cultivated in Owerri, a less industrialized area in Nigeria. The lead (Pb) and cadmium (Cd) contents of the seeds obtained from Rivers State ranged between 0.10 and 0.23 μg/g dry weight, while those of the seeds cultivated in Owerri fell below the detection limit of 0.01 μg/g dry weight. The highest manganese (Mn) level (902 μg/g dry weight) was found in Irvingia garbonesis seeds cultivated in Rivers State. Similarly, the highest nickel (Ni) value (199 μg/g dry weight) was also obtained in I. garbonesis, however, in the seeds sampled in Owerri. The highest copper (Cu), zinc (Zn), and iron (Fe) levels (16.8, 5.27, and 26.2 μg/g dry weight, resp.) were detected in seeds collected in Rivers State. With the exception of Talinum triangulae, Ocinum gratissimum, and Piper guineese, with Pb levels of 0.09, 0.10, and 0.11 μg/g dry weight, respectively, the Pb and Cd levels in the vegetables grown in Owerri fell below the detection limit of 0.01 μg/g dry weight. The trace metal with the highest levels in all the vegetables studied was Mn, followed by Fe. The highest concentrations of Ni and Cu occurred in vegetables collected from Rivers State, while the highest level of Zn was observed in Piper guineese collected in Owerri, with a value of 21.4 μg/g dry weight. Although the trace metal concentrations of the seeds and vegetables collected in Rivers State tended to be higher than those of the seeds and vegetables grown in Owerri, the average levels of trace metals obtained in this study fell far below the WHO specifications for metals in foods.
The electrolysis of aqueous salt solutions in students' laboratory
Authors: Rösch Klaus 
Published: July 2010

AbstractMit einer einfachen und billigen Mini‐Elektrolysezelle kann die Elektrolyse einer wässrigen Natriumchlorid‐Lösung oder anderer Salz‐Lösungen auch im Schülerpraktikum durchgeführt werden. Außerdem stellt die Entsorgung der Elektrolyt‐Lösung nach Beendigung des Praktikums wegen der geringen Mengen der entstandenen Produkte (kurze Elektrolysedauer) kein großes Problem dar. Das Elektrolytvolumen von einer Mini‐Elektrolysezelle beträgt nur ca. 20 cm3. Die nach Beendigung der Elektrolyse vorliegende galvanische Zelle kann durch Messung einer Spannung zwischen den beiden Elektroden bequem festgestellt werden.
Glassware libraries für ACD ChemSketch
Authors: Reiß Philipp 
Published: July 2010

AbstractDie Abbildung von Versuchsaufbauten kann viele Anleitungen erheblich vereinfachen, allerdings waren die entsprechenden Gerätebibliotheken bisher nur begrenzt verfügbar. Mittlerweile gibt es für das weit verbreitete Zeichenprogramm ACD‐ChemSketch zwei kostenlose Gerätebibliotheken, mit denen ohne größeren Aufwand ansprechende Zeichnungen erstellt werden können. Der Umfang der Bibliotheken prädestiniert sie für den Einsatz in der Schule und bei der Kombination beider Bibliotheken können fast alle Anforderungen des Unterrichts abgedeckt werden.
Molecular gastronomy – more than a fashion trend
Authors: Risch Björn , Iseke Michael 
Published: July 2010

AbstractEssbarer Schaum, Stickstoff‐Olivenöl, Fruchtsaft‐Kaviar – an der Molekularküche scheiden sich die Geister. Während die einen den Köchen zujubeln, die mit ihren physikalisch‐chemischen Experimenten eine Küchenrevolution heraufbeschwören, rümpfen die anderen nur verächtlich die Nase und lehnen kategorisch alles ab, was „mit Chemie“ zu tun hat. Was zeichnet die Molekularküche aus und wie schafft sie es, Lebensmittel zu de‐ und rekonstruieren? Hier kann der Chemieunterricht Aufklärung leisten. Darüber hinaus lässt sich anhand des Themas eine kritische Positionierung zu Veränderungen von Lebensmitteln durch Zusatzstoffe erarbeiten.
Retinoic acid and nitric oxide promote cell proliferation and differentially induce neuronal differentiation in vitro in the cnidarian Renilla koellikeri
Authors: Estephane Djoyce , Anctil Michel 
Published: July 2010

AbstractRetinoic acid (RA) and nitric oxide (NO) are known to promote neuronal development in both vertebrates and invertebrates. Retinoic acid receptors appear to be present in cnidarians and NO plays various physiological roles in several cnidarians, but there is as yet no evidence that these agents have a role in neural development in this basal metazoan phylum. We used primary cultures of cells from the sea pansy Renilla koellikeri to investigate the involvement of these signaling molecules in cnidarian cell differentiation. We found that 9‐cis RA induce cell proliferation in dose‐ and time‐dependent manners in dishes coated with polylysine from the onset of culture. Cells in cultures exposed to RA in dishes devoid of polylysine were observed to differentiate into epithelium‐associated cells, including sensory cells, without net gain in cell density. NO donors also induce cell proliferation in polylysine‐coated dishes, but induce neuronal differentiation and neurite outgrowth in uncoated dishes. No other cell type undergoes differentiation in the presence of NO. These observations suggest that in the sea pansy (1) cell adhesion promotes proliferation without morphogenesis and this proliferation is modulated positively by 9‐cis RA and NO, (2) 9‐cis RA and NO differentially induce neuronal differentiation in nonadherent cells while repressing proliferation, and (3) the involvement of RA and NO in neuronal differentiation appeared early during the evolutionary emergence of nervous systems. © 2010 Wiley Periodicals, Inc. Develop Neurobiol 70: 842–852, 2010
Efficient Construction of Highly Substituted and Stereodefined cis‐Fused Lactones
Authors: Elkhayat Zobida , Safir Imad , Gandara Zoila , Retailleau Pascal , Arseniyadis Siméon 
Published: July 2010

AbstractThe methodology described in this paper involves the epoxidation of cyclic ene‐acetals to spontaneously generate 6α‐hydroxy‐bis‐acetals that could serve as precursors for a Cannizzaro‐type rearrangement, yielding bis‐angularly substituted cis‐fused lactones. Both the oxidizing reagent, m‐CPBA or NaBO3, and the substitution pattern can be important in determining the course of the epoxidation/ring‐opening sequence, with NaBO3 being the ideal electrophilic oxidant for the epoxidation/spontaneous ring‐opening/ring‐system interchange sequence.
Three New Sesquiterpenoids from Echinops ritro L.
Authors: Li Liang‐Bo , Ren Jie , Cheng Zheng‐Ming , Zhu Hua‐Jie 
Published: July 2010

AbstractFrom the whole plants of E. ritro L., the three new sesquiterpenoids (3α,4α,6α)‐3,13‐dihydroxyguaia‐7(11),10(14)‐dieno‐12,6‐lactone (1), (3α,4α,6α,11β)‐3‐hydroxyguai‐1(10)‐eno‐12,6‐lactone (2), and (11α)‐11,13‐dihydroarglanilic acid methyl ester (=(4β,6α,11α)‐4,6‐dihydroxy‐1‐oxoeudesm‐2‐en‐12‐oic acid methyl ester; 3), together with eight known sesquiterpenoids, were isolated. Their structures were elucidated through analysis of spectroscopic data including extensive 2D‐NMR.
A Novel and Regiospecific Synthesis of 1‐Aryl‐1H‐benzotriazoles via Copper(I)‐Catalyzed Intramolecular Cyclization Reaction
Authors: Liu Qi‐Lun , Wen Di‐Di , Hang Chen‐Chen , Li Qiu‐Lian , Zhu Yong‐Ming 
Published: July 2010

Abstract1‐Aryl‐1H‐benzotriazole derivatives were synthesized via intramolecular cyclization of easily obtained triazenes, using CuI as the catalyst, DMSO as the solvent, t‐BuONa as the base, and 1,10‐phenanthroline as the ligand, in up to 97% yield. The synthesis is regiospecific and functional group‐tolerant.
New Lactone and Xanthone Derivatives Produced by a Mangrove Endophytic Fungus Phoma sp. SK3RW1M from the South China Sea
Authors: Pan Jia‐Hui , Deng Juan‐Juan , Chen Yi‐Guang , Gao Jun‐Ping , Lin Yong‐Cheng , She Zhi‐Gang , Gu Yu‐Cheng 
Published: July 2010

AbstractA new lactone, 1,8‐dihydroxy‐10‐methoxy‐3‐methyldibenzo[b,e]oxepine‐6,11‐dione (1), and two new xanthones, 1‐hydroxy‐8‐(hydroxymethyl)‐6‐methoxy‐3‐methyl‐9H‐xanthen‐9‐one (2) and 1‐hydroxy‐8‐(hydroxymethyl)‐3‐methoxy‐6‐methyl‐9H‐xanthen‐9‐one (3), were isolated from a mangrove endophytic fungus Phoma sp. SK3RW1M collected from the South China Sea. This is the first report on xanthone derivatives isolated as secondary metabolites from Phoma species. Their structures were elucidated by spectroscopic methods, mainly 1D‐ and 2D‐NMR techniques, and the structure of compound 2 was confirmed by X‐ray crystallography. Cytotoxicity assays showed that compounds 1–3 were inactive against KB and KBv200 cells.
Synthesis of Functionalized Tetrahydro‐4‐oxoindeno[1,2‐b]pyrroles from Ninhydrin, Acetylenedicarboxylates, and Primary Amines
Authors: Yavari Issa , Seyfi Samereh , Nematpour Manijeh , Hossaini Zinatossadat 
Published: July 2010

AbstractA one‐pot synthesis of dialkyl 1,3a,4,8b‐tetrahydro‐3a,8b‐dihydroxy‐1‐alkyl‐4‐oxoindeno[1,2‐b]pyrrole‐2,3‐dicarboxylates via three‐component reaction from indan‐1,2,3‐trione hydrate (ninhydrin), primary amines, and dialkyl acetylenedicarboxylates is described.
Glycosidic Constituents of Celastrus orbiculatus
Authors: Zhang Yang , Tan Chang‐Heng , Tan Jun‐Jie , Yang Pei‐Ming , Jiang Shan‐Hao , Ni Xiang , Zhu Da‐Yuan 
Published: July 2010

AbstractThree new, 1–3, and seven known phenolic and terpenic glycosides were isolated from the BuOH‐soluble fraction of 95% EtOH extract of the roots and rhizomes of Celastrus orbiculatus. The structures of the new compounds were elucidated as carvacrol 2‐O‐α‐L‐rhamnopyranosyl‐(1→6)‐β‐D‐glucopyranoside (1), 5‐methoxycarvacrol 2‐O‐α‐L‐rhamnopyranosyl‐(1→6)‐β‐D‐glucopyranoside (2), and 15‐hydroxytorreyol 10‐O‐β‐D‐apiofuranosyl‐(1→6)‐β‐D‐glucopyranoside (3) on the basis of spectroscopic analysis and chemical methods.
The Biomimetic Synthesis and Final Structure Determination of (+)‐ and (−)‐Centrolobine, Naturally Occurring Diarylheptanoid 2,6‐cis‐Disubstituted Tetrahydro‐2H‐pyrans
Authors: Rogano Frank , Rüedi Peter 
Published: July 2010

AbstractThe enantiomerically pure title compounds were prepared by oxidative cyclization of their optically active diarylheptanoid precursors. The approach is considered as a biomimetic phenol oxidation via an intermediate quinone methide. The absolute configuration of the precursors is retained, and the transition state adopts the sterically most favorable diequatorial arrangement of the 2,6‐substituents to afford the cis‐configured natural products. The outcome unambiguously establishes the absolute configurations and the correlation with the chiroptical data. In addition, a problem of regioisomerism that had not been discussed before was solved, and the original assignment of the position of the MeO group in the natural centrolobines could be confirmed. As such the results are the experimental evidence for the corrections of long‐term inconsistencies we had postulated in an earlier review article.