bluuebunny/crossref_metadata_2025_split huggingface dataset:
Modeling the 2024 Noto Peninsula earthquake tsunami: implications for tsunami sources in the eastern margin of the Japan Sea
Authors: Masuda Hidetoshi , Sugawara Daisuke , Cheng An-Chi , Suppasri Anawat , Shigihara Yoshinori , Kure Shuichi , Imamura Fumihiko 
Published: June 2024

AbstractA moment magnitude (Mw) 7.5 earthquake occurred on January 1, 2024, at the northern tip of the Noto Peninsula, Central Japan, triggering a large tsunami. Seismological and geodetic observations revealed the rupture of mapped submarine active faults. While proximal segment ruptures have been well resolved by previous research, far offshore segments have posed challenges for onshore-based inversions. This emphasizes the necessity for a comprehensive study on the fault through tsunami modeling. Here, we aimed to examine tsunami propagation and inundation using four different fault models to identify the general characteristics of the tsunami source and evaluate the complexities of earthquake- and submarine landslide-induced tsunamis. We identified the simultaneous rupture of two active fault systems as the most suitable model for explaining observed tsunami height and inundation; however, some inconsistencies with observations remained. The propagation process did not follow a concentric pattern but aligned with bathymetric heterogeneity. The findings also suggested potential amplification effects responsible for the devastation of the coast of Iida Bay and indicated a possible submarine landslide in southern Toyama Bay. The findings of the present work could benefit the exploration of a more realistic tsunami source model, considering the differences between observations and simulations. Such efforts, in collaboration with paleotsunami research, can contribute to the improved assessment of hazards from submarine active faults.
A successful complete resection for multidrug-resistant giant gastrointestinal stromal tumor invading the transverse colon with multiple liver metastases in a young female: a case report
Authors: Aso Kenta , Takemura Nobuyuki , Yoshizaki Yuhi , Mihara Fuminori , Inagaki Fuyuki , Yamada Kazuhiko , Kokudo Norihiro 
Published: June 2024

Abstract
Background
Gastrointestinal stromal tumors (GISTs) are rare in young people and are often detected after becoming symptomatic or at an advanced stage. Herein, we report a case of complete reduction surgery for a substantially large malignant gastric GIST with multiple liver metastases in a young woman who successfully resulted in R0 surgery.

Case presentation
An 18-year-old woman presented to our hospital with anorexia and vomiting, and was diagnosed with a 17 cm gastric GIST with transverse colon invasion and multiple liver metastases. Due to being considered unresectable, tyrosine and multi-kinase inhibitor therapy were administered up to the fourth line yielding no response. After careful discussion at a multidisciplinary team conference, pancreatoduodenectomy or distal gastrectomy, transverse colectomy, and resection of the liver metastases were planned. Consequently, distal gastrectomy, transverse colectomy, resection of the liver metastases, and incidental peritoneal metastases were performed. Although the primary goal of the surgery was to reduce the volume of the tumor as much as possible, the results revealed that the complete removal of all detectable tumors was achieved. No recurrence was observed after surgery for 27 months with long-term adjuvant imatinib therapy.

Conclusions
Even for highly advanced GISTs, aggressive surgery followed by adjuvant drug therapy may prolong survival in young patients.
Improving maternal and child nutrition services in community based health planning and services zones in the jirapa municipality of northern ghana-challenges and strategies: the perspective of community health officers
Authors: Tengepare Francis Xavier , Chirawurah Dennis , Apanga Stephen 
Published: June 2024

Abstract
Background
The Community-based Health Planning and Services (CHPS) initiative plays a key role in delivering maternal and child health nutrition services in Ghana. This study explored bottle necks hindering the delivery of maternal and child nutrition services at CHPS zones and searched for strategies to address them from the perspective of community health officers in rural Northern Ghana.

Methods
An exploratory qualitative cross-sectional study design using key informant interviews involving the municipal nutrition officer and Community Health Officers (CHOs) from eleven CHPS zones was carried out in April 2019. Manual data analysis was done using the framework analysis approach in qualitative data analysis for applied policy research.

Results
This study identified challenges of maternal and child nutrition services in the Jirapa municipality to be municipal health directorate and CHPS zone based in nature. Municipal health directorate based challenges were inadequate logistics/medicines; lack of staff training; lack of supervision/monitoring; and inadequate financial support/motivation/incentives. CHPS zone based challenges were lack of planning activities by staff; inadequate home visits; lack of commitment by staff; and lack of community meetings/engagements. Proposed strategies to address municipal health directorate based challenges included adequate provision of logistics/medicines; frequent training of staff in maternal and child nutrition related issues; frequent supervision/monitoring activities from the municipal health directorate; and providing financial support/motivation/incentives at the CHPS zones. Proposed strategies to address CHPS zone based challenges were planning of activities; improved home visits; increased commitment towards delivering maternal and child nutrition services; and frequent community meetings/engagements.

Conclusion
In order to improve maternal and child nutrition services at CHPS zones, there is the need to address certain systemic challenges at both the municipal or district health directorate and CHPS zones levels of the primary health care system. It is recommended that, the Municipal Health Directorate; the Municipal Health Management Team; the Municipal Assembly and all relevant stakeholders involved in improving maternal and child nutrition services at the community level, actively engage CHOs to help address the systemic challenges.
Boring life: early colony formation and growth in the endolithic bryozoan genus Penetrantia Silén, 1946
Authors: Decker Sebastian H. , Lemer Sarah , Decker Simone , Hirose Masato , Johnson Mildred J. , Schwaha Thomas 
Published: June 2024

AbstractAs in most colonial and sessile marine invertebrates, bryozoan life history is characterized by asexual propagation of zooids for colonial growth and by sexual production of larvae for dispersal. However, comprehensive life histories, particularly in cryptic species such as endolithic (boring) bryozoans, remain poorly understood. The ctenostome family Penetrantiidae is widespread from temperate to tropical waters and often found in molluscan shells, offering an opportunity to study the boring lifestyle and its potential impact on bioerosion through growth and settlement experiments. Our research focused on Penetrantia clionoides from Guam in the Pacific Ocean, Penetrantia japonica from Japan, and a Penetrantia species from France in the Atlantic Ocean. We found distinct life histories and reproductive patterns potentially influenced by environmental factors such as temperature and food availability. The tropical P. clionoides displayed higher rates of larval production and growth compared to its temperate counterpart. For instance, the mean stolon extension was 335.2 μm/week in P. clionoides versus 232.1 μm/week in Penetrantia sp. Autozooid development took 13 days in P. clionoides and 31 days in Penetrantia sp. Anatomical features like apertural rims aided in species identification and in understanding larval settlement preferences, suggesting a tendency for philopatric settlement behavior. The bioerosional impact of penetrantiids remains little understood, but we generated first projections of bioerosion rates and a protocol for keeping Penetrantia under laboratory conditions, laying a foundation for further research in this field.
INTERP: Interpreter requirements needed for tissue plasminogen activator evaluations and resulting performance: a retrospective review
Authors: Bu Julia Ting , Meyer Dawn M. , Shifflett Benjamin , Meyer Brett C. 
Published: June 2024

Abstract
Aim
To examine the influence of interpreter service needs (IS) on rt-PA administration time metrics.

Methods
Retrospectively reviewed prospectively collected data from Comprehensive Stroke Center database (January 2011- April 1, 2021) and EMR. Inclusion: Subjects for whom a “stroke code” was activated. Excluded in-house strokes. Baseline characteristics, frequency of rt-PA, rt-PA exclusions and time metrics, NIHSS were compared between patients who did or did not require IS. Analyses utilized ANOVA, t-Test, Brown-Mood Median Test, or Pearson’s Chi-squared test as appropriate.

Results
Of 2,191 patients with stroke code activations, 81 had a documented need for IS. Rt-PA was administered in 9 IS and 358 non-IS patients. Median baseline NIHSS was higher in rt-PA group (9±8 vs 3±9, p<0.005). In IS patients, there were no differences in baseline characteristics between those who received rt-PA and those who did not, including median score for NIHSS aphasia (0±1 vs 0±1, p = 0.46). There were no rt-PA rate differences between those that did not and did require IS (17% vs 11%, p = 0.22). In patients with final diagnosis acute ischemic stroke, patients excluded from rt-PA solely due to being out of the window were more likely to have required IS (59% vs 35%, p = 0.003). Time metrics of rt-PA administration were not different in IS patients.

Conclusions
There was no significant difference in frequency or time metrics of rt-PA administration in patients requiring interpreter services during an acute stroke code. AIS patients requiring an interpreter were more likely to be excluded from rt-PA on the basis of time.
Balloon cells in malformations of cortical development: friends or foes?
Authors: Liu Zili , Shen Xuefeng , Lin Kaomin , Wang Fengpeng , Gao Jin , Yao Yi , Sun Jianyuan 
Published: June 2024

AbstractBalloon cells (BCs) are specific pathological marker of cortical malformations during brain development, often associated with epilepsy and development delay. Although a large number of studies have investigated the role of BCs in these diseases, the specific function of BCs as either epileptogenic or antiepileptic remains controversial. Therefore, we reviewed literatures on BCs, delved into the molecular mechanisms and signaling pathways, and updated their profile in several aspects. Firstly, BCs are heterogeneous and some of them show progenitor/stem cell characteristics. Secondly, BCs are relatively silent in electrophysiology but not completely isolated from their surroundings. Notably, abnormal mTOR signaling and aberrant immunogenic process have been observed within BCs-containing malformations of cortical development (MCDs). The question whether BCs function as the evildoer or the defender in BCs-containing MCDs is further discussed. Importantly, this review provides perspectives on future investigations of the potential role of BCs in epilepsy.
Exploring the uncharted: adenoid cystic carcinoma nestled in temporal bone
Authors: Nibhanupudi Kamala Manogna , Gangapatnam Monika , Padmanaban Elamparidhi , Amirthalingam Umamageswari , Raj Joe Vimal , Bharathi M. 
Published: June 2024

Abstract
Background
Adenoid cystic carcinoma is an uncommon malignancy primarily arising from salivary glands. An extremely rare site for adenoid cystic carcinoma is the skull base. We report a case of adenoid cystic carcinoma of skull base who presented with common complaints of pain and right ear discharge. The discussion is made with emphasis on imaging evaluation simulating infective etiology with adjacent skull base osteomyelitis. Careful observation of the imaging findings and further evaluation of the patient revealed the neoplastic nature of the lesion with the final diagnosis being adenoid cystic carcinoma.

Case presentation
A 40-year-old female presented to our department with complaints of pain and right ear discharge since 6 months with progressive, extensive facial swelling and facial nerve palsy. The patient had undergone modified radical mastoidectomy thrice, but the details were not available. On imaging, there was a heterogenous extensive lesion extending from scalp till upper cervical region with extensive destruction of skull base and intra-cranial extension. The possibilities of temporal bone squamous cell carcinoma and extensive skull base osteomyelitis were considered. Further the biopsy of the lesion revealed adenoid cystic carcinoma.

Conclusions
Extensive lesions of the skull base can be of infective, neoplastic and inflammatory etiology. Distinguishing between these conditions is crucial, as they have similar imaging characteristics but require different management approaches. The presence of a lesion that displaces or destroys fascial planes, accompanied by solid mass-like enhancement, indicates a higher probability of a neoplastic origin rather than an infectious etiology. With squamous cell carcinoma being the most common neoplasm, adenoid cystic carcinoma of the skull base also needs to be understood due to its propensity for perineural spread and a high likelihood of recurrence.
Characterization and utilization capabilities of industrial wastes for green bricks production
Authors: El-Mahllawy Medhat Sobhy , Mohsen Sarah Akram 
Published: June 2024

Abstract
Background
The goal of this study is to develop a feasible and sustainable solution to manage the use of industrial wastes of ground granulated blast-furnace steel slag (GGBS) activated by cement kiln dust (CKD) and quicklime (QL). Using activated GGBS in the manufacture of stabilized green bricks is still uncommon in Egypt in such applications. Five clay-based mixtures, each with varying replacement ratios (5–10, wt.%) of CKD and QL, were studied. Laboratory tests were conducted on cylindrical specimens made from these mixtures, which were left to cure for periods of up to 60 days. The raw materials and lab-made specimens were analyzed using particle size analysis, differential thermal analysis, X-ray fluorescence, and X-ray diffraction techniques. The physical and mechanical properties of the cured specimens were also determined and evaluated according to standard specifications. Furthermore, the durability of the cured specimens was evaluated against collapsibility in water.

ResuIts
It has been observed that adding QL and CKD to the stabilized green specimens of different mixes can enhance their engineering properties with curing age increasing. This is due to the pozzolanic reaction, which fills the pore structure with calcium silicate hydrates and calcium aluminate hydrates gel. The ratio of QL and CKD used significantly affected the engineering properties of the specimens. The study found that using 20% GGBS and 5% QL led to an increase in compressive strength (266 kg/cm2) at the density of (2.15 g/cm3), while also water absorption was reduced (8%) to give superior results. When GGBS and CKD were combined, a higher content of CKD (10 wt.%) gave better results compared to (5 wt.%) CKD. Furthermore, the physical and mechanical properties of the tested specimens (MD 1, MD II, MD III and MD IV) met the acceptable limits of dry compressive strength (30–70 kg/cm2), water absorption (8–15%), and density (1.7–2 gm/cm3), as specified by the Egyptian standard specifications for buildings used compressed earth blocks.

Conclusion
The CKD and QL act as alkali activators for GGBS and can be utilized in masonry construction.
Forecasting methods in Greek coastal shipping: The case of Southwest Crete
Authors: Sitzimis Ioannis 
Published: June 2024

AbstractThe aim of this paper is to exact the most effective model at capturing the seasonal and short-term components of passenger traffic in Southwest Crete coastal shipping. There has been no similar effort in the past. The passenger traffic forecast is crucial for the public and private sector, as it is necessary for decision making. In our analysis we considered the six largest ports of Southwest Crete. The seasonal repeated fluctuations and the quarterly observations made Winter’s triple exponential smoothing, time series decomposition, simple seasonal model, seasonal ARIMA model and Lis’ simplistic forecast suitable for our case. The results showed that in four of the six ports the Winters’ method is best adapted. The port of Gavdos adapts better to the decomposition method and the port of Sougia to Li’s method. No port led, through the seasonal ARIMA models or simple seasonal model, to better results. In most cases, traffic trend did not change over time, the seasonal component significantly affected the time series, and the time series smoothing was strong.
Novel approaches to assess lethal and sublethal effects when evaluating risks of biopesticides toward beneficial arthropod
Authors: Laterza Ilaria , Vitale Maria Luisa , Agostinacchio Maria Francesca , Bennani Zineb , de Lillo Enrico , Tamburini Giovanni , Verrastro Vincenzo , Cavallo Giuseppe , Desneux Nicolas , Biondi Antonio , Santovito Elisa , Cornara Daniele 
Published: June 2024

Abstract

Background
Biopesticides are defined as substances derived from naturally occurring materials (i.e., plants, microorganisms and minerals) characterized by low environmental effects, rapid degradation, and low toxicity for humans and beneficial insects. However, the assumption of safety for beneficials is generally solely based on the evaluation of acute mortality upon exposure, overlooking possible underhanded sublethal effects.

Methods

We selected the parasitoid
Leptomastix
dactylopii
Howard (Hymenoptera: Encyrtidae) attacking the mealybug pest
Planococcus
citri
Risso (Hemiptera: Pseudococcidae) as case study to investigate whether the exposure to four biopesticides authorized in organic citrus orchards in the EU, in addition to a
Clitoria
ternatea
(Fabales: Fabaceae) extract, causes significant alterations in the parasitoid physiology and behavior. Classical ecotoxicological tests aimed at evaluating survival rate, parasitization rate, emergence rate and sex-ratio, have been combined with olfactometry to assess deviation in the dynamics of the orientation toward the host, and with a novel optical oxygen respirometry technique to observe possible alterations in oxygen consumption.

Results

All the tested compounds except spinosad were found to not harm
L.
dactylopii
, causing neither lethal nor significant sublethal effects in the exposed parasitoids compared to the control.

Conclusions
In conclusion, all the tested biopesticides showed compatibility within biological control strategies in a field scenario (i.e., organic orange orchards). Moreover, the screening protocols described in the present manuscript, integrating classical ecotoxicological tests and novel approaches targeting specific behavioral and physiological toxicant-induced alterations, allowed to shed light on the multifaceted impact of biopesticides on natural enemies.
A comparative study on engine vibration reduction in ATV quad bikes through dampers with diverse materials and shapes
Authors: Beldar Pankaj , Patil Nivrutti 
Published: June 2024

AbstractThis study addresses the vital role of engine dampers in reducing vibrations and enhancing ride comfort in quad bikes. Utilizing ANSYS modal analysis and CATIA V5 design, the research aims to optimize damper design by assessing natural frequencies and potential resonance in the cage structure and engine. Through extensive analysis, the study evaluates vibrations transmitted from the engine to the chassis, crucial for understanding and improving overall vehicle performance. Neoprene rubber emerges as the optimal material for vibration dampers, offering superior density, elasticity, stiffness, and damping coefficient. Comparative analysis reveals that Design 3 of the dampers significantly outperforms Design 2 and Design 1, showcasing a remarkable 62% reduction in vibration. However, the study underscores the influence of various factors, such as application specificity and vibration characteristics, on damper effectiveness. Thus, while Design 3 may excel under certain conditions, careful consideration of diverse a variable is essential for optimal damper selection and performance across different engine types and operational contexts.
Enhanced antibacterial properties of enteric glial cells attenuate intestinal inflammation through the GABABR-mediated autophagy pathway
Authors: Deng Ziteng , Lan Jing , Wang Jiaqi , Wang Lu , Hao Zhihui , Ma Yunfei 
Published: June 2024

AbstractEnterotoxigenic Escherichia coli (ETEC) infection is a severe threat to global public health because of its high morbidity and mortality among children and infants. Enteric glial cells (EGCs) are involved in host–bacteria communication. However, the mechanisms through which EGCs interact with ETEC remain unclear. We attempted to assess whether γ-aminobutyric acid type B receptor (GABABR) activation participated in EGC autophagy during Escherichia coli K88 (ETECK88) infection. Alterations in autophagy and EGC activity were observed in the intestines of the ETECK88-infected mice, and similar results were obtained from experiments in which the EGCs were directly infected with ETECK88. EGC pretreatment with specific autophagy agonists significantly decreased the inflammatory response and bacterial burden, whereas pretreatment with inhibitors had the opposite effect. Interestingly, in EGCs, GABABR activation notably increased Beclin 1 and LC3 levels and autophagosome and autolysosome numbers, thus promoting autophagy activation and enhancing antimicrobial responses against ETECK88 infection. Furthermore, GABABR defense was mediated via myeloid differentiation factor 88 (MyD88) signaling in EGCs, which was proven to be based on the inhibition or overexpression of MyD88. Notably, comparable results of GABABR activation in vivo were observed in response to ETECK88, implicating this as a defense mechanism that reinforced antibacterial activity to alleviate intestinal inflammation in mice. Our study revealed previously unappreciated roles for GABABR in linking EGC antibacterial autophagy to strengthen host defense against ETECK88 infection, thus identifying GABABR as an important target for the treatment of infective enteritis.