bluuebunny/crossref_metadata_2025_split huggingface dataset:
Role of lateral suspension for the treatment of pelvic organ prolapse: a Delphi survey of expert panel
Authors: Simoncini Tommaso , Panattoni Andrea , Cadenbach-Blome Tina , Caiazzo Nicola , García Maribel Calero , Caretto Marta , Chun Fu , Francescangeli Eric , Gaia Giorgia , Giannini Andrea , Hegenscheid Lucas , Luisi Stefano , Mannella Paolo , Mereu Liliana , Montt-Guevara Maria Magdalena , Ñiguez Isabel , Ritter Ratiba , Russo Eleonora , Ferrer Maria Luisa Sanchez , Tammaa Ayman , Uhl Bernhard , Wiedemann Bea , Wilczak Maciej , Pauli Friedrich , Dubuisson Jean 
Published: June 2024

Abstract
Introduction and hypothesis
Lateral suspension is an abdominal prosthetic surgical procedure used to correct apical prolapse. The procedure involves the placement of a T-shaped mesh on the anterior vaginal wall and on the isthmus or uterine cervix that is suspended laterally and posteriorly to the abdominal wall. Since its description in the late 90s, modifications of the technique have been described. So far, no consensus on the correct indications, safety, advantages, and disadvantages of this emerging procedure has been reached.

Methods
A modified Delphi process was used to build consensus within a group of 21 international surgeons who are experts in the performance of laparoscopic lateral suspension (LLS). The process was held with a first online round, where the experts expressed their level of agreement on 64 statements on indications, technical features, and other aspects of LLS. A subsequent re-discussion of statements where a threshold of agreement was not reached was held in presence.

Results
The Delphi process allowed the identification of several aspects of LLS that represented areas of agreement by the experts. The experts agreed that LLS is a safe and effective technique to correct apical and anterior prolapse. The experts highlighted several key technical aspects of the procedure, including clinical indications and surgical steps.

Conclusions
This Delphi consensus provides valuable guidance and criteria for the use of LLS in the treatment of pelvic organ prolapse, based on expert opinion by large volume surgeons’ experts in the performance of this innovative procedure.
Normalized solutions for a fractional Schrödinger–Poisson system with critical growth
Authors: He Xiaoming , Meng Yuxi , Squassina Marco 
Published: June 2024

AbstractIn this paper, we study the fractional critical Schrödinger–Poisson system $$\begin{aligned}{\left\{ \begin{array}{ll} (-\Delta )^su +\lambda \phi u= \alpha u+\mu |u|^{q-2}u+|u|^{2^*_s-2}u,&{}~~ \hbox {in}~{\mathbb {R}}^3,\\ (-\Delta )^t\phi =u^2,&{}~~ \hbox {in}~{\mathbb {R}}^3,\end{array}\right. } \end{aligned}$$

(
-
Δ
)

s

u
+
λ
ϕ
u
=
α
u
+

μ
|
u
|

q
-
2

u
+

|
u
|

2
s
∗

-
2

u
,

in

R

3

,

(
-
Δ
)

t

ϕ
=

u
2

,

in

R

3

,

having prescribed mass $$\begin{aligned} \int _{{\mathbb {R}}^3} |u|^2dx=a^2,\end{aligned}$$

∫

R

3

|
u
|

2

d
x
=

a
2

,

where $$ s, t \in (0, 1)$$

s
,
t
∈
(
0
,
1
)

satisfy $$2\,s+2t> 3, q\in (2,2^*_s), a>0$$

2

s
+
2
t
>
3
,
q
∈
(
2
,

2
s
∗

)
,
a
>
0

and $$\lambda ,\mu >0$$

λ
,
μ
>
0

parameters and $$\alpha \in {\mathbb {R}}$$

α
∈
R

is an undetermined parameter. For this problem, under the $$L^2$$

L
2

-subcritical perturbation $$\mu |u|^{q-2}u, q\in (2,2+\frac{4\,s}{3})$$

μ
|
u
|

q
-
2

u
,
q
∈

(
2
,
2
+

4

s

3

)

, we derive the existence of multiple normalized solutions by means of the truncation technique, concentration-compactness principle and the genus theory. In the $$L^2$$

L
2

-supercritical perturbation $$\mu |u|^{q-2}u,q\in (2+\frac{4\,s}{3}, 2^*_s)$$

μ
|
u
|

q
-
2

u
,
q
∈

(
2
+

4

s

3

,

2
s
∗

)

, we prove two different results of normalized solutions when parameters $$\lambda ,\mu $$

λ
,
μ

satisfy different assumptions, by applying the constrained variational methods and the mountain pass theorem. Our results extend and improve some previous ones of Zhang et al. (Adv Nonlinear Stud 16:15–30, 2016); and of Teng (J Differ Equ 261:3061–3106, 2016), since we are concerned with normalized solutions.
Towards anti-racist futures: a scoping review exploring educational interventions that address systemic racism in post graduate medical education
Authors: Mukhopadhyay Baijayanta , Thambinathan Vivetha , Kinsella Elizabeth Anne 
Published: June 2024

AbstractSince 2020, brought to the forefront by movements such as Black Lives Matter and Idle No More, it has been widely acknowledged that systemic racism contributes to racially differentiated health outcomes. Health professional educators have been called to address such disparities within healthcare, policy, and practice. To tackle structural racism within healthcare, one avenue that has emerged is the creation of medical education interventions within postgraduate residency medical programming. The objective of this scoping review is to examine the current literature on anti-racist educational interventions, that integrate a systemic or structural view of racism, within postgraduate medical education. Through the identification and analysis of 23 papers, this review identified three major components of interest across medical interventions, including (a) conceptualization, (b) pedagogical issues, and (c) outcomes & evaluation. There were overlapping points of discussion and analysis within each of these components. Conceptualization addressed how researchers conceptualized racism in different ways, the range of curricular content educators chose to challenge racism, and the absence of community’s role in curricular development. Pedagogical issues addressed knowledge vs. skills-based teaching, and tensions between one-time workshops and integrative curriculum. Outcomes and evaluation highlighted self-reported Likert scales as dominant types of evaluation, self-evaluation in educational interventions, and misalignments between intervention outcomes and learning objectives. The findings are unique in their in-depth exploration of anti-racist medical interventions within postgraduate medical education programming, specifically in relation to efforts to address systemic and structural racism. The findings contribute a meaningful review of the current state of the field of medical education and generate new conversations about future possibilities for a broader anti-racist health professions curriculum.
Comprehensive genomic profiling of ESR1, PIK3CA, AKT1, and PTEN in HR(+)HER2(−) metastatic breast cancer: prevalence along treatment course and predictive value for endocrine therapy resistance in real-world practice
Authors: Bhave Manali A. , Quintanilha Julia C. F. , Tukachinsky Hanna , Li Gerald , Scott Takara , Ross Jeffrey S. , Pasquina Lincoln , Huang Richard S. P. , McArthur Heather , Levy Mia A. , Graf Ryon P. , Kalinsky Kevin 
Published: June 2024

Abstract
Background
The treatment landscape for HR(+)HER2(−) metastatic breast cancer (MBC) is evolving for patients with ESR1 mutations (mut) and PI3K/AKT pathway genomic alterations (GA). We sought to inform clinical utility for comprehensive genomic profiling (CGP) using tissue (TBx) and liquid biopsies (LBx) in HR(+)HER2(−) MBC.

Methods
Records from a de-identified breast cancer clinicogenomic database for patients who underwent TBx/LBx testing at Foundation Medicine during routine clinical care at ~ 280 US cancer clinics between 01/2011 and 09/2023 were assessed. GA prevalence [ESR1mut, PIK3CAmut, AKT1mut, PTENmut, and PTEN homozygous copy loss (PTENloss)] were calculated in TBx and LBx [stratified by ctDNA tumor fraction (TF)] during the first three lines of therapy. Real-world progression-free survival (rwPFS) and overall survival (rwOS) were compared between groups by Cox models adjusted for prognostic factors.

Results
~ 60% of cases harbored 1 + GA in 1st-line TBx (1266/2154) or LBx TF ≥ 1% (80/126) and 26.5% (43/162) in LBx TF < 1%. ESR1mut was found in 8.1% TBx, 17.5% LBx TF ≥ 1%, and 4.9% LBx TF < 1% in 1st line, increasing to 59% in 3rd line (LBx TF ≥ 1%). PTENloss was detected at higher rates in TBx (4.3%) than LBx (1% in TF ≥ 1%). Patients receiving 1st-line aromatase inhibitor + CDK4/6 inhibitor (n = 573) with ESR1mut had less favorable rwPFS and rwOS versus ESR1 wild-type; no differences were observed for fulvestrant + CDK4/6 inhibitor (n = 348).

Conclusion
Our study suggests obtaining TBx for CGP at time of de novo/recurrent diagnosis, followed by LBx for detecting acquired GA in 2nd + lines. Reflex TBx should be considered when ctDNA TF < 1%.
The Economic Dynamics After a Flood: Evidence from Satellite Data
Authors: Collalti Dino 
Published: June 2024

AbstractThis study investigates the effect of flash floods on local economic activity in Central America and the Caribbean. I measure these rarely analyzed floods by constructing a high-resolution, physically based index of flash flood occurrence from satellite data and connect these to changes in local night light emissions. After accounting for tropical cyclone activity, flash floods have a delayed, short-term negative effect on economic activity. In countries with a low to medium human development index (HDI), the average negative effect can be up to $$5.6\%$$

5.6
%

in the following months. Countries with higher HDI appear more resilient and are only marginally affected. Also, flash floods exhibit a minor positive spatial spillover in low to medium HDI countries, besides their more substantial local negative effect. Due to their high frequency, flash floods have a detrimental effect on local economic growth in developing countries that will likely be exacerbated by climate change. (JEL )
Energy audits in the tofu industry; an evaluation of energy consumption towards a green and sustainable industry
Authors: Ningsih Lydia Mawar , Mazancová Jana , Hasanudin Udin , Roubík Hynek 
Published: June 2024

AbstractThe tofu industry consumes a lot of energy and water for its process production and then produces wastewater in large quantities that have a negative effect on the environment. It is because tofu craftsmen still use conventional technology in the process production, and there is no SOP for the use of raw materials and energy sources, and there is also a lack of capability in waste management. This study aims to investigate the audit energy in the tofu industry, including evaluating the consumption energy in different energy sources, determining the production of wastewater in the tofu industries and determining the energy sources available in the tofu industry. The data collection method involved semi-structured interviews and questionnaire surveys carried out in 40 tofu industries in Gunung Sulah district, Bandar Lampung City, Lampung Province, Indonesia. The results showed that the highest consumption in process production in the tofu industry is for cooking that depends on the type of energy sources, namely firewood 71.1 MJ/kg, LPG 16.9 MJ/kg, and wood pellets 6.0 MJ/kg. However, the consumption of water for the production of the process is 25.2 L/kg and produces 14.5 L/kg wastewater. The tofu industry is still not efficient in consuming energy because it does not use wastewater to produce a bioenergy product that can be beneficial in economic and environmental aspects. To make energy consumption more efficient in the tofu industry, it is very useful to use wastewater to produce bioenergy material that can replace non-renewable energy as the main energy for process production. Based on the prediction that the potential for methane from tofu wastewater is approximately 0.056 m3/kg soybeans, the use of tofu wastewater as biogas feedstock can replace 2.82% of firewood, 11.86% LPG, and 33.39% biopellets.
Department Chairs as Change Agents: A Virtual Cross-Institutional Professional Development Model for Chairs
Authors: Cervato Cinzia , Peterson Stephanie , Johnson Carrie Ann , Bilen-Green Canan , Koretsky Carla , Minerick Adrienne , Kremer Gul Okudan 
Published: June 2024

Abstract
Department chairs are crucial in impacting departmental climate, conveying expectations, and providing merit assessments. Therefore, they have the most influence in retaining highly qualified faculty. Most department chairs come from the faculty ranks and lack formal training in key management, communication, and administrative skills, including performance reviews, resource allocation and budgeting, legal and compliance issues, promotion and tenure determinations, conflict resolution, and the inclusive management of people with diverse identities. Recognizing the critical role of department chairs and the evident gap in their training, we developed a series of chair workshops to provide ongoing professional development for department chairs across multiple semesters. These workshops were designed as part of a multi-university collaboration funded by the National Science Foundation to create more inclusive environments in science, technology, engineering, and mathematics (STEM) units. However, the offerings were expanded to include all units on all campuses. This paper outlines our approach to developing these professional development workshops and describes the workshop designs and how we incorporated participant feedback. Additionally, we offer suggestions for others designing and implementing chair professional development workshops together with areas for future advancements in chair professional development.
Developmental Assessment in Children at Higher Likelihood for Developmental Delays - Comparison of Parent Report and Direct Assessment
Authors: Stephenson Kevin G. , Vargo Kerrigan C. , Cacciato Nicole M. , Albright Charles M. , Kryszak Elizabeth M. 
Published: June 2024

Abstract
Purpose
Accurate assessment of cognitive development of young children is a vital component of developmental evaluations. Direct assessment of developmental skills is not always feasible, but there is limited information on the agreement between direct assessment and caregiver-reported cognitive skills. There is limited information regarding the accuracy of the parent-reported Developmental Profile 4 (DP-4) in comparison to the widely-used developmental measure, the Bayley Scales of Infant and Toddler Development, Fourth Edition (Bayley-4). The purpose of the current study was to evaluate whether a standardized parent interview can effectively identify children at risk for cognitive developmental delays.

Methods
We compared the agreement between the Bayley-4 Cognitive and the Developmental Profile 4 (DP-4) in young children being evaluated in-person for early developmental delays. 182 children (134 with an autism diagnosis), ages 6–42 months, completed both assessments.

Results
Results showed that Bayley-4 Cognitive scores had a moderately strong correlation with DP4-Cognitive scores (r = 0.70, p < 0.001). A cutoff of 70 or 69 on the DP-4 Cognitive was determined as ideal for identifying developmental delay based on diagnosis of global developmental delay or the Bayley-4 Cognitive.

Conclusions
Our analyses revealed good agreement between DP-4 and Bayley-4 Cognitive scores, even after controlling for confounding variables such as degree of ASD characteristics, age, and sex. These results suggest that caregiver-report measures can be a valid and useful tool in the assessment of young children, particularly when direct developmental assessment is not feasible.
The Association Between Depression, Suicidal Thoughts and Intimate Partner Violence Perpetration Among Young Men in Mwanza, Tanzania
Authors: Aloyce Diana , Stöckl Heidi , Mosha Neema , Malibwa Donati , Sichalwe Simon , Hashim Ramadhan , Ayieko Philip , Kapiga Saidi , Mshana Gerry 
Published: June 2024

Abstract
Purpose
Depression and suicidal thoughts are associated with intimate partner violence, a major public health problem. Yet little is known about this association among young men in sub-Saharan Africa. This study aims to investigate the relationship between depression, suicidal thoughts and intimate partner violence perpetration, among young men in Tanzania from a representative community-based sample.

Methods
We conducted a cross sectional survey among 1002 young men aged between 18 and 24 years residing in Mwanza city, Tanzania. Participants were randomly selected from 6 wards that included 3 densely and 3 sparsely populated wards from the Ilemela and Nyamagana districts that were selected using a probability-based multi-stage cluster sampling approach. We collected data on participant’s socio-demographics, depression symptoms using the PHQ9, suicidal thoughts, other psychosocial factors, and perpetration of different forms of intimate partner violence. Analysis was done using Stata version 17.0 and restricted to 828 participants who self-reported being in intimate relationships in the past twelve months. Bivariate and multivariable logistic regression models were employed to determine the association between the outcome variables with intimate partner violence perpetration and other psychosocial factors.

Results
Out of 828 young men, 333(40.2%) reported depressive symptoms and 93(11.9%) suicidal thoughts, with 725(87.6%) reporting ever perpetrating any form of intimate partner violence and 653(78.9%) reporting it in the past 12 months. After adjusting for other factors in multivariable models, depressive symptoms were significantly associated with sexual intimate partner violence perpetration (aOR = 2.19, 95%CI = 1.57, 3.04), economic intimate partner violence perpetration (aOR = 1.32 95%CI = 1.01, 1.74), emotional intimate partner violence perpetration (aOR = 1.76, 95%CI = 1.26, 2.46) and controlling behaviours (aOR = 1.46 95%CI = 1.10, 1.93).

Conclusions
Depression is a common health problem strongly associated with intimate partner violence perpetration in this study population. Effective interventions to address depression and other mental health problems may help to reduce intimate partner violence perpetration in this population.

Implications
Researchers and practitioners should develop theory-based research and intervention programmes to address mental health problems such as depression and suicidal thoughts and the perpetration of intimate partner violence. The socio-ecological framework provides an insightful model for multiple level analysis and intervention.
Compensating beneficiaries
Authors: Eggert Linda 
Published: June 2024

AbstractThis paper illuminates a typically obscured ground for rectificatory obligations: harms justified as ‘lesser evils.’ Lesser-evil harms are not the result of overall morally prohibited acts but of acts permissibly carried out to prevent significantly greater harm. The paper argues that harms caused as unintended side effects of acting on lesser-evil justifications, notably in military rescue operations, may give rise to claims to compensation, even if (1) the military acts that caused the harms in question were justified on lesser-evil grounds and (2) the victims in question are no worse off as a result; they may even owe their survival to the act of rescue. The paper defends three claims. First, being better off as a result of a harmful rescue than one would otherwise have been does not preclude claims to be compensated for harms suffered as a side effect. Second, identifying the relevant counterfactual for purposes of compensatory justice is sometimes a prescriptive, rather than a descriptive, matter. Rather than relying on empirical speculations about what would have happened had a harm not occurred, we must, in certain cases, consider what agents ought to have done. Finally, duties of compensation need not fall on those who caused the to-be-compensated harms. That infringing rights is permissible in certain cases does not imply that no compensation is owed, but merely that it is not necessarily rights-infringers on whom duties of compensation fall.
Centromere sequence-independent but biased loading of subgenome-specific CENH3 variants in allopolyploid Arabidopsis suecica
Authors: Karimi-Ashtiyani Raheleh , Banaei-Moghaddam Ali Mohammad , Ishii Takayoshi , Weiss Oda , Fuchs Jörg , Schubert Veit , Houben Andreas 
Published: June 2024

AbstractCentromeric nucleosomes are determined by the replacement of the canonical histone H3 with the centromere-specific histone H3 (CENH3) variant. Little is known about the centromere organization in allopolyploid species where different subgenome-specific CENH3s and subgenome-specific centromeric sequences coexist. Here, we analyzed the transcription and centromeric localization of subgenome-specific CENH3 variants in the allopolyploid species Arabidopsis suecica. Synthetic A. thaliana x A. arenosa hybrids were generated and analyzed to mimic the early evolution of A. suecica. Our expression analyses indicated that CENH3 has generally higher expression levels in A. arenosa compared to A. thaliana, and this pattern persists in the hybrids. We also demonstrated that despite a different centromere DNA composition, the centromeres of both subgenomes incorporate CENH3 encoded by both subgenomes, but with a positive bias towards the A. arenosa-type CENH3. The intermingled arrangement of both CENH3 variants demonstrates centromere plasticity and may be an evolutionary adaption to handle more than one CENH3 variant in the process of allopolyploidization.
Evaluating the contribution of plant metabolic pathways in the light to the ATP:NADPH demand using a meta-analysis of isotopically non-stationary metabolic flux analyses
Authors: Smith Kaila , Strand Deserah D. , Walker Berkley J. 
Published: June 2024

AbstractBalancing the ATP: NADPH demand from plant metabolism with supply from photosynthesis is essential for preventing photodamage and operating efficiently, so understanding its drivers is important for integrating metabolism with the light reactions of photosynthesis and for bioengineering efforts that may radically change this demand. It is often assumed that the C3 cycle and photorespiration consume the largest amount of ATP and reductant in illuminated leaves and as a result mostly determine the ATP: NADPH demand. However, the quantitative extent to which other energy consuming metabolic processes contribute in large ways to overall ATP: NADPH demand remains unknown. Here, we used the metabolic flux networks of numerous recently published isotopically non-stationary metabolic flux analyses (INST-MFA) to evaluate flux through the C3 cycle, photorespiration, the oxidative pentose phosphate pathway, the tricarboxylic acid cycle, and starch/sucrose synthesis and characterize broad trends in the demand of energy across different pathways and compartments as well as in the overall ATP:NADPH demand. These data sets include a variety of species including Arabidopsis thaliana, Nicotiana tabacum, and Camelina sativa as well as varying environmental factors including high/low light, day length, and photorespiratory levels. Examining these datasets in aggregate reveals that ultimately the bulk of the energy flux occurred in the C3 cycle and photorespiration, however, the energy demand from these pathways did not determine the ATP: NADPH demand alone. Instead, a notable contribution was revealed from starch and sucrose synthesis which might counterbalance photorespiratory demand and result in fewer adjustments in mechanisms which balance the ATP deficit.