bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mechanistic aspects of the bromination of 10‐substituted phenothiazines
Authors: Chiou Huh‐Sun , Reeves P. C. , Biehl E. R. 
Published: April 2009

AbstractThe addition of 1 and 2 molar equivalents of bromine to a series of 10‐alkylphenothiazines, 1a‐d (methyl, ethyl, n‐propyl, and isopropyl, respectively), yields the corresponding 3‐bromo‐ and 3,7‐dibromo‐10‐alkylphenothiazines (11a‐d and 12a‐d, respectively). Evidence which supports the typical clectrophilic aromatic substitution mechanism is presented. Radical cations (12a‐d.+) arc produced when 12a‐d are treated with 1 or 2 molar equivalents of bromine. Upon boiling in acetic acid these radical cations are converted predominantly to 1,3,7,9‐lelrabromophenothiazine (5) and the parent 3,7‐dibromo‐10‐alkylphenothiazine (12a‐d) with the evolution of hydrogen bromide. The 10‐methyl radical (12a) gives, in addition, 1,3,7‐tribromo‐10‐methylphenothiazine (15). A mechanism if proposed for these reactions in which initial dealkylution of 12b‐d.+ to 3.7‐dibromophenothiazine radical cation (13) occurs followed by reduction of 13.+ by bromide ion to parent 3,7‐dibromophenothiazine (13). Subsequent bromination of 13 by molecular bromine produced in the previous redox reaction yields 1,3,7‐tribromo‐(14) and 1,3,7,9‐tetra‐bromo‐(5) phenothiazines. The small size of the methyl group allows 12a to be brominated at the 1‐position prior to dealkylation. In addition to undergoing bromination at the 3‐ and 7‐position, 10‐isopropylphenothiazine (1d) is oxidized to the radical cation 12e.+ when treated with bromine. 10‐Benzylphenothiazine (1e), however, undergoes oxidation to radical cation 1e.+ exclusively. This radical cation debenzylates readily at room temperature and is converted finally into phenothiazine.
Synthesis of some 3‐Methyl‐11H‐indolo[3,2‐c] [1,8]naphthyridines. A New heterocyclic ring system
Authors: Da Settimo A. , Primofiore C. , Biagi G. , Santerini V. 
Published: April 2009

AbstractSome derivatives of 11H‐indolo[3,2‐c] [1,8]naphthyridine, a new heterocyclic system, have been prepared using the Fischer indole synthesis on the appropriately phenylhydrazones. The preparation of some substituted 5,6‐dihydro‐11H‐indolo[3,2‐c][1,8]naphthyridines is also described.
Acetylinic ketones. Part II.. Reaction of acetylenic ketones with nucleophilic nitrogen compounds
Authors: Baddar F. C. , Al‐Hajjar F. H. , El‐Rayyes N. R. 
Published: April 2009

AbstractAroylphenylacetylenes (I) reacted with ethyl and phenyl hydrazinecarboxylates (II) to give ω‐aroylacetophenone‐N‐ethoxycarbonyl‐(Vla‐f) and N‐phenoxycarbonyl‐(VIg‐l) hydrazones, respectively. When these were healed with acetic anhydride they were converted to 5‐aryl‐1‐ethoxycarbonyl‐and 1‐phenoxycarbonyl‐3‐phenylpyrazoles (VII), respectively, which on hydrolysis with rnethanolic potassium hydroxide gave the corresponding 5(3)aryl‐3(5)phenylpyrazoles (VIII).Reaction of the above acetylenic ketones with guanidine hydrochloride in the presence of sodium carbonate gave the corresponding 2‐amino‐6‐aryl‐4‐phenylpyrimidines (XII). Similarly, reaction of benzoylphenylacetylene with thiourea and with urea in the presence of sodium ethoxide gave rise to 2,4‐diphenylpyrimidine‐2‐thione (XVIII) and 2,4‐diphenyl‐2(1H)pyrimidin‐one (XV), respectively.
Cyclic condensations of 2‐amino‐1,3,4‐thiadiazole with 1,3‐dicarbonyl compounds
Authors: Lauer R. F. , Zenchoff G. 
Published: April 2009

AbstractThe reactions of 2‐amino‐1,3,4‐thiadiazole with 1,3‐dicarbonyl compounds are described. 2,4‐Pentanedione gave 2‐thiocyanato‐4,6‐dimethylpyrimidine while diethylmalonate and ethyl acetoacetate yielded 5‐hydroxy‐7H‐1,3,4‐thiadiazolo[3,2‐a]pyrimidin‐7‐one and 7‐methyl‐5H‐1,3,4‐thiadiazolo[3,2‐a]pyrimidin‐5‐one, respectively. The structure of the latter compound was confirmed by a synthesis of the alternative isomeric structure (5‐methyl‐7H‐1,3,4‐thiadiazolo[3,2‐a]pyrirnidin‐7‐one) from 2‐amino‐1,3,4‐thiadiazole and α‐bromocrotonic acid.
Benzomorphan related compounds. III.. Structural determination of Δ3 ‐ and Δ4‐tetrahydropyridines by nuclear magnetic resonance
Authors: Bosch J. , Canals J. , Giralt E. , Granados R. 
Published: April 2009

AbstractObservation of the nmr spectra of several Δ3 ‐ and Δ4‐tetrahydropyridines hydrochlorides provides a useful method for the structural determination of this type of compound. The Δ3 ‐ Isomers exist as one predominant epimer only whereas the Δ4‐isomers exist as a mixture of the two possible epimers. The respective assignments are discussed in view of the criteria previously applied in the study of this type of compound.
4‐Substituted‐4H‐pyrrolo[2,1‐c] [1,4]benzoxazines
Authors: Jirkovsky I. , Humber L. G. , Baudy R. 
Published: April 2009

AbstractThe condensations of 1‐(2‐hydroxyphenyl) pyrroles with a variety of carbonyl compounds are shown to give new 4‐substituted‐4H‐4‐methylpyrrolo[2,1‐c][1,4]benzoxazines. Some of the products were further functionalized. The ir, uv, and pmr spectra of the title heterocyclic system are discussed. Reaction of 1‐(2‐hydroxyphenyl) pyrrole with dimethyl acetylenedicarboxylate yielded dimethyl 3‐(2‐hydroxyanilino) phthalale; a mechanistic rationale which accounts for the result involves a rearrangement of the hypothetical Diels‐Alder adduct.
The interaction of cis and trans‐1‐cyclohexyl‐2‐phenyl‐3‐benzoylaziridine with lithium N‐Methylanilide
Authors: Tarburton Philip , Wall D. K. , Cromwell Norman H. 
Published: April 2009

AbstractA reaction pathway for the rearrangement‐dehydrogenation of cis‐1‐cyclohexyl‐2‐phenyl‐3‐benzoylaziridine into 2‐cyclohexylamino‐3‐phenylindenone can now be suggested. Furthermore, a competing degradation pathway involving CC bond scission accounts for the major product in these reactions and leads to ω‐cyclohexylaminoacetophenone and benzaldehyde. Observed also is the fact that trans‐1‐cyclohexyl‐2‐phenyl‐3‐benzoylaziridine fails to undergo the rearrangement‐dehydrogenation reaction.
Nucleophilic character of alkyl radicals. XIV. Homolytic δ‐aminoalkylation of protonated quinoxaline
Authors: Caronna T. , Citterio A. , Crolla T. , Ghirardini M. , Minisci F. 
Published: April 2009

AbstractA new general reaction of wide synthetic interest, involving homolytic δ‐aminoalkylation of quinoxaline in acidic medium, is described. Primary and secondary alkylamines, through the corresponding N‐chloroamines, and tertiary alkylamines, through the corresponding N‐oxides, are used. The mechanism of the reaction, involving intramolecular hydrogen abstraction by amino radical cations, and the unusual selectivity are discussed in terms of nucleophilic character of the alkyl radicals and of polar effects in the aromatic substitution.
Studies on the synthesis of heterocyclic compounds. Synthesis of 1,3,2‐benzoxathia‐ and 1,3,2‐benzodioxastibole derivatives
Authors: Anchisi Carlo , Corda Luciano , Maccioni Antonio , Podda Gianni , Cabiddu Salvatore 
Published: April 2009

AbstractThe preparation of 1,3,2‐benzoxathia‐ and 1,3,2‐benzodioxachlorostiboles (IIa‐b) by reaction of antimony trichloride with 2‐hydroxythiophenol (Ia) or 1,2‐benzodiol (Ib) is described. The halogen was easily removed. Thus a Wurtz‐like reaction gave the distibole compounds (IVa‐b), which were also produced by organolithium compounds or pyridine. The compounds Va‐b were obtained with sodium hydroxide, ethoxide and phenoxide, but spiran derivatives VIIa‐b, of antimony, were obtained by treating IIa‐b with 2‐hydroxythiophenol or 1,2‐benzodiol in the presence of triethylamine. The structure of the prepared compounds was determined by spectro‐scopic methods.
Isothiazoles VII: N‐hydroxyalkylation and mannich reaction of 4‐isothiazolin‐3‐one
Authors: Weiler Ernest D. , Miller George A. 
Published: April 2009

AbstractHydroxyalkylation and the synthesis of Mannich bases of 4‐isothiazolin‐3‐one are described. Conversion of hydroxyalkyl to haloalkyl derivatives and the preparation of 2‐arylcarbamoyloxy‐methyl‐4‐isothiazolin‐3‐ones are also reported.
On the grignard reaction of 2‐bromo‐3‐iodo‐ and 3‐bromo‐2‐chlorothiophene
Authors: Gronowitz Salo , Pettersson Kerstin 
Published: April 2009

Abstract2‐Bromo‐3‐iodo‐ and 3‐bromo‐2‐chlorothiophene react with magnesium in the presence of 1,2‐dibrornoethane to give 2‐halo‐3‐thiophene magnesium halide which opens a useful route to 2,3‐disubstituted thiophenes having an electron‐withdrawing group in the 3‐position.
Nitrofuranyl heterocycles. XIIIN‐methyl‐3‐methylthio‐5‐(5‐nitro‐2‐furanyl)‐1H‐1,2,4‐triazoles
Authors: Benjamin Louis E. , Snyder Harry R. 
Published: April 2009

AbstractA continuing search for new nitrofurans which might possess useful antimicrobial activity led to the synthesis of several 3‐mercapto‐5‐(5‐nitro‐2‐furanyl)‐1H‐1,2,4‐triazoles and their methylated derivatives. This paper describes the preparation of these compounds together with proof of structure of the N‐methylated products.
Synthetic studies of the antitumor antibiotic streptonigrin. II. Synthesis of the C‐D ring portion of streptonigrin
Authors: Liao T. K. , Wittek Philip J. , Cheng C. C. 
Published: April 2009

AbstractPartial mclhylalion of gallopropiophenonc (4) followed by benzylation and base‐catalyzed condensation with ethyl acetate yielded 3‐(2‐benzyloxy‐3,4‐din]etlK>xy)benzoyl‐2‐butanonc (6). Animation of the latter and subsequent base‐catalyzed cyclization with ethyl cyanoacetate gave 4‐(2‐benzyloxy‐3,4‐dimethoxy)phenyl‐5,6‐dimethyl‐2‐oxo‐1,2‐dihydropyridine (8). Removal of the 2‐oxo group of 8 through chlorination and dechlorination and stepwise conversion of the 5‐cyano and 2‐methyl groups into the 5‐amino and 2‐carboxylic acid groups, respectively, with introduction and removal of protecting groups at proper stages, yielded the C‐D ring moiety of the antitumor antibiotic streptonigrin.
Synthesis of some N‐substituted 4,5‐dihydro‐7,8‐dirnethoxybenzothiazepin‐3‐one 1,1 ‐dioxides
Authors: Catsoulacos Panayotis , Camoutsis Ch. 
Published: April 2009

AbstractReaction of ethyl 3,4‐dimethoxyphenylpropionale with chlorosulfonic acid yielded 2‐carbo‐elhoxyethyl‐3,4‐dimelhoxybenzene sulfochloride, which was converted to 2‐earboethoxyethyl‐3,4‐dimethoxybenzcnesulfonamides by the action of ammonia or substituted aromatic amines. Alkaline hydrolysis of these sulfonumide esters furnished the corresponding acids. The reaction of acids with phosphorus pentachloride resulted in the key intermediates, the ehloroearboxycthyl‐3,4‐dimethoxybenzenesulfonamides. The latter was cyelized to N‐substituted 4,5‐dihydro‐7,8‐dirnelhoxybenzothizepine‐3 ‐one 1, 1‐dioxide. Reactions of benzolhiazepinonc ring and nrnr specttra are described.
Synthesis of a new heterocyclic ring system 2,3,5,6,7,9,10,11‐octahydro‐lH‐cyclopenta[9,H)]benzo[i,j] quinolizine‐1,9‐dione
Authors: Dike Suneel Y. , Merchant J. R. 
Published: April 2009

AbstractReaction of 1,2,3,4‐tetrahydroquinoline (1) with different α,β‐unsaturated acids in the presence of PPA has been investigated. With acrylic acid, 1 affords two compounds identified as 1‐keto‐benzo[i,j]quinolizine (III) and 2,3,5,6,7,9,10,1 1‐octahy dro‐1H‐cy el open ta [9,10] benzo [i,j]‐quinolizine‐1,9‐dione (IV). A similar reaction of 1 with a‐methyl acrylic and crotonie acids gives compounds V and VI whose structures are analogous to that of IV. These were deduced from their spectral and analytical data.
Nouvelles synthèses de thiéno[3,2‐c] ‐ et thiéno[2,3‐c]pyridines
Authors: Maffrand J. P. , Eloy F. 
Published: April 2009

AbstractLes auteurs décrivent une nouvelle méthode de synthèse des thiéno[2,3‐c]‐ et [3,2‐c]pyridines et de quelques dérivés tetrahydrogénés, basée sur des modifications de la reaction de Pomeranz‐Fritsch de formation des isoquinoléines.
The synthesis of 2‐amino‐7‐(β‐D‐ribofuranosyl)pyrrolo[2,3‐d]‐pyrimidin‐4‐one (7‐deazaguanosine), a nucleoside Q and Q* analog
Authors: Townsendxs Leroy B. , Tolman Richard L. , Robins Roland K. , Milne George H. 
Published: April 2009

AbstractThe synthesis of 2‐amino‐7‐(β‐D‐riholuranosyl)pyrrolo[2,3‐d ]pyrimidin‐4‐one (7‐deazaguanos‐ine, a nucleoside Q and Q* analog, has been accomplished hy two independcnl routes.
BCL‐2 and BAX proteins expression throughout the light–dark cycle and modifications induced by sleep deprivation and rebound in adult rat brain
Authors: Montes‐Rodríguez Corinne J. , Alavez Silvestre , Soria‐Gómez Edgar , Rueda‐Orozco Pavel E. , Guzman Khalil , Morán Julio , Prospéro‐García Oscar 
Published: April 2009

AbstractIt has been suggested that sleep has a restorative function; however, experimental support is limited. Hence, we investigated whether changes in the level of antiapoptotic BCL‐2 protein and proapoptotic BAX protein occur during sleep deprivation (SD) and sleep rebound, and evaluated the spontaneous changes in these proteins, along the light–dark cycle, in the adult male Wistar rat. Estimations were made in the prefrontal cortex, hippocampus, striatum, and pons. We observed that BCL‐2 exhibited diurnal variations in the prefrontal cortex and striatum, whereas BAX varied in the striatum and showed only small variations in the pons as measured by immunoblotting. The BCL‐2/BAX ratio exhibited diurnal variations in the prefrontal cortex and striatum. BCL‐2 and BAX levels were affected by 24 hr of total SD and 24 hr of sleep rebound. SD decreased the BCL‐2/BAX ratio in the prefrontal cortex and pons. Sleep rebound increased the BCL‐2/BAX ratio in the hippocampus. In conclusion, the BCL‐2/BAX ratio is high during the dark phase as compared with the light phase in the prefrontal cortex and during the light phase as compared with the dark phase in the striatum. SD decreased the BCL‐2/BAX ratio in the prefrontal cortex and pons, whereas sleep rebound increased it in the hippocampus. These changes point out structures in the brain that express these proteins as a response to the light–dark cycle. Similarly, SD and sleep rebound seem to change these proteins expression in some other brain structures, suggesting that cellular vulnerability might be altered by these changes. © 2009 Wiley‐Liss, Inc.
Neue Impulse aus der Goldkatalyse
Authors: Hashmi A. Stephen K. 
Published: April 2009

AbstractA. Stephen K. HashmiGoldkatalysatoren liefern Beiträge zu wichtigen Themen der nachhaltigen Chemie: Oxidation mit molekularem Sauerstoff und kohlenhydratbasierte Bausteine aus nachwachsenden Rohstoffen.
”Der Staat ist verantwortlich für die gesellschaftliche Vision“
Authors: Mertin Michael 
Published: April 2009

AbstractÜber Agendasetting und globale Kooperationsformen sprachen die Nachrichten aus der Chemie mit Michael Mertin, dem Vorstand Technologie der Jenoptik, beim Villa‐Hügel‐Gespräch in Essen. Der Physiker fordert in der Forschungsförderung für Unternehmen mehr Planung und Verlässlichkeit.
A study of critical reasoning in online learning: application of the Occupational Performance Process Model
Authors: Mitchell Anita Witt , Batorski Rosemary E. 
Published: April 2009

AbstractThis study examined the effect of an online guided independent study on critical reasoning skills. Twenty‐one first‐semester Master of Occupational Therapy students completed an online assignment designed to facilitate application of the Occupational Performance Process Model (Fearing & Clark) and kept reflective journals. Data from the journals were analyzed in relation to the three sets of questions, question type and results of the Watson‐Glaser Critical Thinking Appraisal (WGCTA). This assignment appeared to be effective for enhancing awareness and use of critical reasoning skills. Differences in patterns of critical reasoning between students with high and low WGCTA scores and results of an inductive analysis of the journal entries are discussed. Future research investigating the types of feedback that effectively facilitate development of critical reasoning and whether students with high and low WGCTA scores might benefit from different types of instruction and/or feedback is recommended. Copyright © 2009 John Wiley & Sons, Ltd.
Prognosis in pediatric hematologic malignancies is associated with serum concentration of mannose‐binding lectin‐associated serine protease‐2 (MASP‐2)
Authors: Zehnder Aina , Fisch Urs , Hirt Andreas , Niggli Felix K. , Simon Arne , Ozsahin Hulya , Schlapbach Luregn J. , Ammann Roland A. 
Published: April 2009

AbstractBackgroundMannose‐binding lectin (MBL) and MBL‐associated serine protease‐2 (MASP‐2) are key components of the lectin pathway of complement activation. Their serum concentrations show a wide interindividual variability. This study investigated whether the concentration of MBL and MASP‐2 is associated with prognosis in pediatric patients with cancer.MethodsIn this retrospective multicenter study, MBL and MASP‐2 were measured by commercially available ELISA in frozen remnants of serum taken at diagnosis. Associations of overall survival (OS) and event‐free survival (EFS) with MBL and MASP‐2 were assessed by multivariate Cox regression accounting for prognostically relevant clinical variables.ResultsIn the 372 patients studied, median serum concentration of MBL was 2,808 µg/L (range, 2–10,060) and 391 µg/L (46–2,771) for MASP‐2. The estimated 4‐year EFS was 0.60 (OS, 0.78). In the entire, heterogeneous sample, MBL and MASP‐2 were not significantly associated with OS or EFS. In patients with hematologic malignancies, however, higher MASP‐2 was associated with better EFS in a significant and clinically relevant way (hazard ratio per tenfold increase (HR), 0.22; 95% CI, 0.09–0.54; P = 0.001). This was due to patients with lymphoma (HR, 0.11; 95% CI, 0.03–0.47; P = 0.003), but less for those with acute leukemia (HR, 0.35; 95% CI, 0.11–1.15; P = 0.083).ConclusionIn this study, higher MASP‐2 was associated with better EFS in pediatric patients with hematologic malignancies, especially lymphoma. Whether MASP‐2 is an independent prognostic factor affecting risk stratification and anticancer therapy needs to be assessed in prospective, disease‐specific studies. Pediatr Blood Cancer 2009;53:53–57. © 2009 Wiley‐Liss, Inc.
Two‐dimensional native electrophoretic analysis of respiratory supercomplexes from Yarrowia lipolytica
Authors: Nübel Esther , Wittig Ilka , Kerscher Stefan , Brandt Ulrich , Schägger Hermann 
Published: April 2009

AbstractMitochondria of the strictly aerobic yeast Yarrowia lipolytica contain respiratory complex I with close functional and structural similarity to the mammalian enzyme. Unlike mammalian mitochondria, however, Yarrowia mitochondria have been thought not to contain supercomplexes. Here, we identify respiratory supercomplexes composed of complexes I, III and IV also in Y. lipolytica. Evidence for dimeric complex I suggests further association of respiratory supercomplexes into respiratory strings or patches. Similar supercomplex organization in Yarrowia and mammalian mitochondria further makes this aerobic yeast a useful model for the human oxidative phosphorylation system. The analysis of supercomplexes and their constituent complexes was made possible by 2‐D native electrophoresis, i.e. by using native electrophoresis for both dimensions. Digitonin and blue‐native electrophoresis were generally applied for the initial separation of supercomplexes followed by less mild native electrophoresis variants in the second dimension to release the individual complexes from the supercomplexes. Such 2‐D native systems are useful means to identify the constituent proteins and their copy numbers in detergent‐labile physiological assemblies, since they can reduce the complexity of supramolecular systems to the level of individual complexes.
Identification of CHI3L1 and MASP2 as a biomarker pair for liver cancer through integrative secretome and transcriptome analysis
Authors: Wang Jun , Gao Feng , Mo Fan , Hong Xu , Wang Hongyang , Zheng Shusen , Lin Biaoyang 
Published: April 2009

AbstractHepatocellular carcinoma (HCC) is the fifth most frequent neoplasm with more than 500 000 new cases diagnosed yearly. Novel liver cancer biomarkers are needed. By tandem mass spectrometry, we analyzed the secretomes of 12 individual paired samples of liver cancer and adjacent normal tissues and identified 1528 proteins with >2 unique peptide hits. The false discovery rate was 3.4%. Using spectral counting, we found 87 proteins in the HCC group and 86 proteins in the normal group that showed fivefold overexpression. These proteins provided a rich source of biomarker candidates. We presented a novel paradigm in combining biomarkers that include an up‐regulated cancer biomarker and a down‐regulated organ‐enriched marker, and identified chitinase‐3‐like protein 1(CHI3L1) and mannan‐binding lectin serine peptidase 2 (MASP2) as the top biomarker pair for HCC diagnosis using integrative transcriptomics and proteomics analysis. Using ELISA assays, we further evaluated this biomarker pair in a separate cohort of 25 serum samples of liver cancer patients and 15 age‐matched normal controls. The combined marker pair (YKL40/MASP2 ratio) performed better than either marker alone with an AUC of 0.97 for liver cancer diagnosis. Further validation of the biomarker pair in HCC patients versus disease controls and independent cohorts is warranted.
The incidence and management of siaolocele after parotidectomy
Authors: Witt Robert L. 
Published: April 2009

Objectives(1) To determine if a postparotidectomy sialocele occurs at a higher incidence with a partial superficial parotidectomy compared with a near‐complete parotidectomy and (2) to determine if needle aspiration versus observation yield more persistent sialoceles beyond 1 month.Study DesignA single‐surgeon, single‐institution case series with a chart review.MethodsComparing 100 consecutive partial superficial parotidectomy procedures and 20 consecutive near‐total parotidectomy procedures for formation of a postoperative sialocele. Patients were evaluated at 1 week and 1 month postoperatively. The first 18 sialoceles were treated with one or more needle aspirations. The last 21 sialoceles were treated with observation.ResultsThere were 39 sialoceles in the partial superficial parotidectomy group (39/100, 39%) and none in the near‐total parotidectomy group (0/20, 0%) (P < 0.05). All sialoceles resolved by the end of the first postoperative month whether aspirated or not aspirated.ConclusionsSialoceles are common postpartial superficial parotidectomy, and they did not occur after near‐total parotidectomy. Sialoceles can generally be treated by observation with an expectation of resolution within 1 month.
Diet and feeding of the musky octopus, Eledone moschata, in the northern Adriatic Sea
Authors: Krstulović Šifner Svjetlana , Vrgoč Nedo 
Published: April 2009

This paper presents data on the diet of the musky octopus, Eledone moschata, caught with bottom-trawl nets in the northern Adriatic Sea from October 2001 to June 2003. A total of 1226 stomachs were examined, out of which 34.8% were empty. Several indices were used to describe the diet of the species. Crustaceans were found to be the most important prey category and their remains occurred in 65.0% of stomachs with food. Fish and cephalopods were present in 37.8% and 21.8% of stomachs, respectively. Differences in food composition between smaller and larger individuals were observed. In specimens with mantle lengths up to 80 mm crustaceans dominated, occurring in 79.4% of examined stomachs. Important prey categories of the larger specimens (>80 mm) were crustaceans, fish and cephalopods. No significant differences in the diet between males and females were found. Cannibalism occurred only occasionally and at larger sizes. Seasonal changes in the diet were observed, but seasonality did not seem to be a limiting factor in the feeding intensity of the species. Results indicate that the observed differences in the diet composition and feeding dynamics of the musky octopus are primarily due to the animals' changes in size.