bluuebunny/crossref_metadata_2025_split huggingface dataset:
Relationship between quality‐management systems and organizational innovations
Authors: Llach Josep , Casadesus Martí , Marimon Frederic 
Published: September 2010

AbstractThe purpose of this study is to ascertain whether there is any correlation between the implementation of quality‐management systems (QMSs) in manufacturing firms and the use of certain organizational innovations in those firms. A conceptual model of the relationships among the constructs of “organizational innovations” and “level of quality management” is proposed and tested. The study finds a correlation between the level of quality management in an organization and the implementation ofproceduralorganizational innovations. Because the study is pioneering and exploratory in nature, the analysis is confined to the use of a limited number of organizational innovations in Spanish manufacturing firms. The findings will assist managers to make appropriate strategic decisions when implementing QMSs. © 2010 Wiley Periodicals, Inc.
Work system design in macroergonomics: A case study related to prioritization of major sociotechnical system components by using the fuzzy analytic network process
Authors: Koyuncu Gürkan , Kurt Eda , Erensal Yasemin Claire 
Published: September 2010

AbstractThe primary lesson for a company in an industrially developing country that desires to build its competitive capabilities is that investing and focusing solely on the technical side of the work system results in disruptive technological and organizational change. The managers should take into account the broader prerequisites and be aware of the potential pitfalls of work system incompatibilities. Past experiences indicate that, to be successful, the work system design has to match certain requirements of major sociotechnical systems. Thus the matching process has to consider multiple criteria and the opinions of several managers. This work attempts briefly to identify factors affecting the success of work system design to reduce the potential for incompatibilities with respect to macroergonomics and to optimize the decision process of managers. The objective of the presented decision model in this article, based on the fuzzy analytic network process, determines the global weights (highest degree of importance) for different sociotechnical subsystem components/elements and examines the critical factors and benefits that affect the successful application of macroergonomic work system designs from a manager's point of view. © 2010 Wiley Periodicals, Inc.
Dietary factors and in situ and invasive cervical cancer risk in the European prospective investigation into cancer and nutrition study
Authors: González Carlos A. , Travier Noemie , Luján‐Barroso Leila , Castellsagué Xavier , Bosch F. Xavier , Roura Esther , Bueno‐de‐Mesquita H. Bas , Palli Domenico , Boeing Heiner , Pala Valeria , Sacerdote Carlotta , Tumino Rosario , Panico Salvatore , Manjer Jonas , Dillner Joakim , Hallmans Göran , Kjellberg Lennart , Sanchez María‐José , Altzibar Jone M. , Barricarte Aurelio , Navarro Carmen , Rodriguez Laudina , Allen Naomi , Key Timothy J. , Kaaks Rudolf , Rohrmann Sabine , Overvad Kim , Olsen Anja , Tjønneland Anne , Munk Christian , Kjaer Susanne Krüger , Peeters Petra H.M. , van Duijnhoven Fränzel J.B. , Clavel‐Chapelon Françoise , Boutron‐Ruault Marie‐Christine , Trichopoulou Antonia , Benetou Vasiliki , Naska Androniki , Lund Eiliv , Engeset Dagrun , Skeie Guri , Franceschi Silvia , Slimani Nadia , Rinaldi Sabina , Riboli Elio 
Published: September 2010

AbstractSome dietary factors could be involved as cofactors in cervical carcinogenesis, but evidence is inconclusive. There are no data about the effect of fruits and vegetables intake (F&V) on cervical cancer from cohort studies. We examined the association between the intake of F&V and selected nutrients and the incidence of carcinoma in situ (CIS) and invasive squamous cervical cancer (ISC) in a prospective study of 299,649 women, participating in the European Prospective Investigation into Cancer and Nutrition study. Cox proportional hazard models were used to estimate adjusted hazard ratios (HRs) and 95% confidence intervals (95% CI). A calibration study was used to control measurement errors in the dietary questionnaire. After a mean of 9 years of follow‐up, 253 ISC and 817 CIS cases were diagnosed. In the calibrated model, we observed a statistically significant inverse association of ISC with a daily increase in intake of 100 g of total fruits (HR 0.83; 95% CI 0.72–0.98) and a statistically nonsignificant inverse association with a daily increase in intake of 100 g of total vegetables (HR 0.85: 95% CI 0.65–1.10). Statistically nonsignificant inverse associations were also observed for leafy vegetables, root vegetables, garlic and onions, citrus fruits, vitamin C, vitamin E and retinol for ISC. No association was found regarding beta‐carotene, vitamin D and folic acid for ISC. None of the dietary factors examined was associated with CIS. Our study suggests a possible protective role of fruit intake and other dietary factors on ISC that need to be confirmed on a larger number of ISC cases.
How to kill tumor cells with inhibitors of poly(ADP‐ribosyl)ation
Authors: Mangerich Aswin , Bürkle Alexander 
Published: September 2010

AbstractPoly(ADP‐ribosyl)ation is a post‐translational modification catalyzed by the enzyme family of poly(ADP‐ribose) polymerases (PARPs). PARPs exhibit pleiotropic cellular functions ranging from maintenance of genomic stability and chromatin remodeling to regulation of cell death, thereby rendering PARP homologues promising targets in cancer therapy. Depending on the molecular status of a cancer cell, low‐molecular weight PARP inhibitors can (i) either be used as monotherapeutic agents following the concept of synthetic lethality or (ii) to support classical chemotherapy or radiotherapy. The rationales are the following: (i) in cancers with selective defects in homologous recombination repair, inactivation of PARPs directly causes cell death. In cancer treatment, this phenomenon can be employed to specifically target tumor cells while sparing nonmalignant tissue. (ii) PARP inhibitors can also be used to sensitize cells to cytotoxic DNA‐damaging treatments, as some PARPs actively participate in genomic maintenance. Apart from that, PARP inhibitors possess antiangiogenic functions, thus opening up a further option to inhibit tumor growth. In view of the above, a number of high‐potency PARP inhibitors have been developed during the last decade and are currently evaluated as cancer therapeutics in clinical trials by several leading pharmaceutical companies.
Gold(III)‐dithiocarbamato anticancer agents: Activity, toxicology and histopathological studies in rodents
Authors: Marzano Cristina , Ronconi Luca , Chiara Federica , Giron Maria Cecilia , Faustinelli Ivo , Cristofori Patrizia , Trevisan Andrea , Fregona Dolores 
Published: September 2010

AbstractGold(III)‐dithiocarbamato complexes have recently gained increasing attention as potential anticancer agents because of their strong tumor cell growth–inhibitory effects, generally achieved by exploiting non‐cisplatin‐like mechanisms of action. The rationale of our research work is to combine the antitumor properties of the gold(III) metal center with the potential chemoprotective function of coordinated dithiocarbamates in order to reduce toxic side effects (in particular nephrotoxicity) induced by clinically established platinum‐based drugs. In this context, [AuIIIBr2(ESDT)] (AUL12) was proved to exert promising and outstanding antitumor activity in vitro and to overcome both acquired and intrinsic resistance showed by some types of tumors toward cisplatin. As a subsequent extension of our previous work, we here report on detailed in vivo studies in rodents, including antitumor activity toward three transplantable murine tumor models, toxicity, nephrotoxicity and histopathological investigations. Remarkably, the gold(III) complex AUL12 stands out for higher anticancer activity than cisplatin toward all the murine tumor models examined, inducing up to 80% inhibition of tumor growth. In addition, it shows low acute toxicity levels (lethal dose, LD50 = 30 mg kg−1) and reduced nephrotoxicity. Altogether, these results confirm the reliability of our drug design strategy and support the validation of this gold(III)‐dithiocarbamato derivative as a suitable candidate for clinical trials.
Prevalence of genotype‐specific human papillomavirus infection and cervical neoplasia in Taiwan: A community‐based survey of 10,602 women
Authors: Chen Hui‐Chi , You San‐Lin , Hsieh Chang‐Yao , Schiffman Mark , Lin Ching‐Yu , Pan Mei‐Hung , Chou Yi‐Chun , Liaw Kai‐Li , Hsing Ann W. , Chen Chien‐Jen ,   CBCSP‐HPV Study Group
Published: September 2010

AbstractHuman papillomavirus (HPV) causes cervical neoplasia; but limited data are available from Asia. We conducted a large‐scale community‐based cohort study in Taiwan to estimate prevalence of genotype‐specific HPV infection and cervical neoplasia. Following written informed consent, cervical cells for cytology and HPV testing were collected from 11,923 participants (aged 30–65 years old, mean 46.3) in 1991–1992. Genotyping was performed using MY11/GP6+ PCR‐based HPV Blot (EasyChip) for 39 HPV types. The overall HPV prevalence was 16.2% for 10,602 eligible participants, and 13.8% for 10,190 cytologically normal participants. The most common carcinogenic types were HPV52 (2.5%), HPV16 (2.0%), HPV56 (1.8%), HPV18 (1.6%), HPV33 (1.2%), HPV58 (1.3%) and HPV39 (1.0%). Among the 56 prevalent invasive and in situ cases, HPV16 (48.2%) was most common, followed by HPV58 (25.0%), HPV52 (19.6%), HPV31 (8.9%), HPV33 (8.9%) and HPV18 (3.6%). HPV16 and HPV58 caused cytological HSIL+ at younger ages than HPV52. Approximately half of the cervical cancer cases and high‐grade precursors in Taiwan could be prevented by prophylactic vaccines against HPV16 and HPV18 infection. Up to 40% more could be prevented by targeting HPV58, HPV52, HPV33 and HPV31, arguing for the introduction of vaccines including more types.
The Contribution of Microelectrodes to Electroanalytical Chemistry: From Reaction Mechanisms and Scanning Electrochemical Microscopy to Ocean Sensors
Authors: Denuault Guy 
Published: September 2010

AbstractThe advent of microelectrodes has opened new areas of study and significantly improved the quality of electroanalytical data. Using examples from the author’s work, this brief review describes contributions made by microelectrodes to the field of electroanalytical chemistry. Several fundamental studies, ranging from the development of theoretical approaches for the scanning electrochemical microscope to the determination of the mechanism and kinetics of coupled chemical reactions, are recalled. Most involve a serious dose of numerical simulations. Several applied studies illustrate the development of experimental approaches, in particular the development of nanostructured microelectrodes, to improve the reliability and quality of the microelectrode response for analytical measurements and sensing.
Treatment of adult insomnia with cognitive–behavioral therapya
Authors: Pigeon Wilfred R. 
Published: September 2010

AbstractInsomnia is a highly prevalent disorder that occurs frequently in its acute form and at a rate of approximately 10% in its chronic form. There is a high prevalence of insomnia in a variety of medical and psychiatric conditions. Cognitive–behavioral therapy (CBT) may be employed for chronic insomnia as well as for insomnia in the context of other conditions such as chronic pain conditions. In such cases, some simple adaptations to standard CBT for insomnia are useful. This article reviews the typical assessment and CBT for adult insomnia, which have substantial empirical support for its efficacy. A case illustrates the core treatment processes and demonstrates that improving sleep in the context of conditions like chronic pain can lead to better management of such conditions. © 2010 Wiley Periodicals, Inc. J Clin Psychol: In Session 66:1–13, 2010.
Infestation experience of a rodent host and offspring viability of fleas: variation among host–parasite associations
Authors: Khokhlova Irina S. , Ghazaryan Lusine , Degen A. Allan , Krasnov Boris R. 
Published: September 2010

AbstractWe studied survival and development of preimagoes and the ability to withstand starvation of adults in two flea species, host‐specificParapulex chephrenisand host‐opportunisticXenopsylla ramesis, when parent fleas fed on a typical (Acomys cahirinusandDipodillus dasyurus, respectively) or an atypical (D. dasyurusandA. cahirinus, respectively) rodent host that either had never been parasitized by fleas (pristine) or had previously been exposed to fleas. We asked whether a repeatedly infested host acquired resistance that would cause decreased viability of the next generation fleas. Survival of preimaginalP. chephreniswas similar, independent of host species or its infestation status. PreimaginalX. ramesishad a higher survival rate when their parents fed on preinfested than on pristine typical hosts, whereas no effect of infestation status of an atypical host was found.P. chephrenisdeveloped faster if their parents fed on atypical than on typical hosts and on pristine than on preinfested hosts of either species.X. ramesisdeveloped faster if parents fed on pristine than preinfested typical hosts, but no difference in duration of development was found for atypical hosts. Under starvation,P. chephrenislived longer if their parents fed on preinfested than on pristine typical hosts, but their lifespan did not depend on infestation status of atypical hosts. The latter was also true forX. ramesisand both host species. We conclude that a host is constrained in its ability to cope with a parasite, whereas a parasite is able to cope with defence responses of a host.J. Exp. Zool. 313A:680–689, 2010. © 2010 Wiley‐Liss, Inc.
The peacock's train (Pavo cristatus and Pavo cristatus mut. alba) I. structure, mechanics, and chemistry of the tail feather coverts
Authors: Weiss Ingrid M. , Kirchner Helmut O.K. 
Published: September 2010

AbstractThe feathers in the train of the peacock serve not for flying but for sexual display. They are long, slender beams loaded in bending by their own weight. An outer circular conical shell, the cortex, is filled by a closed foam of 7.6% relative density, the medulla, both of feather keratin. Outer diameter and thickness of the cortex decrease linearly from the body toward the tip. This self‐similar geometry leads to a division of labor. The cortex (longitudinal Young's modulus 3.3 GPa, transverse modulus 1 GPa) provides 96% of the longitudinal strength and bending rigidity of the feather. The medulla (Young's modulus 10 MPa) provides 96% of the transverse compressive rigidity. Fracture stress of the cortex, both longitudinal and transverse, is 120 MPa. J. Exp. Zool. 313A:690–703, 2010. © 2010 Wiley‐Liss, Inc.
Potential genetic bases of morphological evolution in the triassic fish Saurichthys
Authors: Schmid Leonhard , Sánchez‐Villagra Marcelo R. 
Published: September 2010

AbstractOriginating from an ancestor covered entirely by uniform rhomboid scales with numerous, highly segmented fin rays, the Triassic basal actinopterygian fish Saurichthys radiated into species diagnosed by different degrees of loss in scales, rays, and dermal bones. Such changes are analogous to those reported in mutants of different extant species, such as sticklebacks, zebrafish, and medaka. With this background, we infer a loss of function or a regulatory change of a signaling pathway as a key mechanism behind the morphological diversity of Saurichthys. Either the fibroblast growth factor pathway was affected, assuming that gene duplication had occurred, as for example in the closely related acipenserids or in teleosts, or the ectodysplasin pathway was involved, assuming that its pleiotropic effects led to viable morphological diversification. In contrast to a gradualistic model of evolution, a change in a major developmental gene serves as a viable explanation for the essential differences among the species of Saurichthys in the paleoecological context in which they originated. J. Exp. Zool. (Mol. Dev. Evol.) 314B:519–526, 2010. © 2010 Wiley‐Liss, Inc.
Reactivity of gaseous sodiated ions derived from benzene dicarboxylate salts toward residual water in the collision gas
Authors: Chan Chang‐Ching , Axe Frank U. , Bolgar Mark , Attygalle Athula B. 
Published: September 2010

AbstractThe sodium adduct of disodium salts of benzene dicarboxylic acids (m/z 233), when subjected to collision‐induced dissociation (CID), undergoes a facile loss of CO2 to produce an ion of m/z 189, which retains all the three sodium atoms of the precursor. The CID spectrum of this unusual m/z 189 ion shows significant peaks at m/z 167, 63 and 85. The enigmatic m/z 167 ion, which appeared to represent a loss of a 22‐Da neutral fragment from the precursor ion is in fact a fragment produced by the interaction of the m/z 189 ion with traces of water present in the collision gas. The change of the m/z 167 peak to 168, when D2O vapor was introduced to the collision gas of a Q‐ToF instrument, proved that such an intervention of water could occur even in collision cells of tandem‐in‐space mass spectrometers. The m/z 189 ion has such high affinity for water; it forms an ion/molecule complex even during the brief residence time of ions in collision cells of triple quadrupole instruments. The complex formed in this way then eliminates elements of NaOH to produce the ion observed at m/z 167. In an ion trap, the relative intensity of the m/z 167 peak increases with longer activation time even at the lowest possible collision energy setting. Similarly, the m/z 145 ion (which represents the sodium adduct of phenelenedisodium, formed by two consecutive losses of CO2 from the m/z 233 ion of meta‐ and para‐isomers) interacts with water to produce a fragment ion at m/z 123 for the sodium adduct of phenylsodium. Other uncommon ions that originate also from water/ion interactions are observed at m/z 85 and 63 for [Na3O]+ and [Na2OH]+, respectively. Tandem mass spectrometric experiments conducted with appropriately deuterium‐labeled compounds confirmed that the proton required for the formation of the [Na2OH]+ ion originates from traces of water present in the collision gas and not from the ring protons of the aromatic moiety. Copyright © 2010 John Wiley & Sons, Ltd.
Epidemiological and molecular assessment of a rubella outbreak in North‐Eastern Italy
Authors: D'Agaro Pierlanfranco , Dal Molin Gianna , Zamparo Emanuela , Rossi Tatiana , Micuzzo Michele , Busetti Marina , Santon Daniela , Campello Cesare 
Published: September 2010

AbstractFrom January to June 2008, a rubella outbreak involving 111 laboratory confirmed cases occurred in the Friuli Venezia Giulia (FVG) region of North‐Eastern Italy. The outbreak occurred initially in two residential homes for young adults disabled mentally and physically. Subsequently, the epidemic spread to the general population. Young adult cohorts were mostly affected and the mean age of the patients was 26.8 years; the majority of cases were male (73.8%), with a mean age of 26.6 years in males and 27.4 in females. Three pregnant women had a primary infection and two had their pregnancies terminated. Genotyping of 16 isolates showed the circulation of RUBV 2B, a genotype originating from Asia and South Africa and now present in Europe. In addition, molecular analysis revealed a well defined space‐temporal spread of two viruses showing distinct sequences. A seroepidemiological survey carried out in a city within the same geographical area showed that the proportion of women of childbearing age still susceptible to rubella virus was 5.5%, fairly close to the figure (<5%) expected by 2010. J. Med. Virol. 82:1976–1982, 2010. © 2010 Wiley‐Liss, Inc.
Toll‐like receptor 7 rs179008/Gln11Leu gene variants in chronic hepatitis C virus infection
Authors: Askar Eva , Ramadori Giuliano , Mihm Sabine 
Published: September 2010

AbstractHepatitis C virus (HCV) infection affects an estimated 3% of the world's population. The natural outcome of infection and the natural course of disease are highly variable. Sensing of viral single‐stranded RNA (ssRNA) by Toll‐like receptor 7 (TLR7) is likely involved in early pathogen detection and host response to viral infections. This study analyzed epidemiological and clinical data from 136 patients with HCV infection with regard to rs179008/Gln11Leu, a non‐synonymous polymorphism within exon 3 of the X‐linked TLR7 gene, the variant allele of which is suggested to code for a functionally impaired protein. Allele‐specific transcript quantification (ASTQ) analyses in heterozygous females revealed individual skewed mosaicism in peripheral blood mononuclear cells (PBMCs). Thus, analyses were restricted to homo‐ and hemizygous individuals. Among the clinical and histological parameters studied, the variant allele T was found to be solely associated with the presence of portal lymphoid aggregates. Whereas hepatic viral load and expression of genes known to be induced in chronic HCV infection were not found to differ in patients with wild‐type or variant TLR7 rs179008 genotype, significant lower gene expression of interleukin‐29 (IL‐29)/lambda1 interferon (IFN‐λ1) and both of its receptor subunits was found for T homo‐ and hemizygous patients. Irrespective of the minor differences in disease phenotype including hepatic viral load, natural, and alpha interferon (IFN‐α)‐mediated outcome of infection, and disease activity and progression, the significant differences in hepatic IL‐29/IFN‐λ1 and IFN‐λ receptor gene expression between TLR7 rs179008 T and A allele patients might have implications for responsiveness to future IFN‐λ‐based approaches. J. Med. Virol. 82:1859–1868, 2010. © 2010 Wiley‐Liss, Inc.
Differential cellular immune responses to wild‐type and attenuated edmonston tag measles virus strains are primarily defined by the viral phosphoprotein gene
Authors: Haralambieva Iana H. , Ovsyannikova Inna G. , Dhiman Neelam , Vierkant Robert A. , Jacobson Robert M. , Poland Gregory A. 
Published: September 2010

AbstractThe measles virus phosphoprotein (P) gene encodes the P, V, and C proteins, which have multiple functions including type I interferon (IFN) inhibition. With a focus on viral immune modulation, we conducted a study on healthy vaccinees (n = 179) to compare cytokine secretion patterns/cell frequencies and gene expression after in vitro encounter with a highly attenuated strain of measles virus (MVEdmtag), wild‐type MV (MVwt) or recombinant MVEdmtag expressing the wild‐type P gene (MVwtP). Cytokines were quantified by ELISA and Elispot. Gene expression profiling was performed using real‐time PCR. We found differential MV‐specific cytokine responses to all detected cytokines characterized by significantly higher cytokine levels (P < 0.001) and higher frequencies (P < 0.0001) of cytokine‐producing cells after stimulation with the highly attenuated MVEdmtag strain in comparison with MVwt or MVwtP. Furthermore, gene expression profiling revealed significant cytokine suppression at the transcriptional level for viruses encoding the functional wt P gene, compared to attenuated MVEdmtag (P < 0.05). Using lentivirus‐mediated stable expression of P gene‐encoded proteins in human cell lines, we demonstrated that the expression of the functional wt V protein significantly down‐modulated the induction of IFNs type I, II, and III in lymphocytes and monocytes. Taken together our results indicate that Th1, Th2, and innate/inflammatory cytokine responses in vaccinees are suppressed both at the protein and transcriptional level by viruses expressing the functional wt P gene products. The functional P gene‐encoded viral proteins (particularly V proteins) emerge as crucial immune evasion factors for modulating and shaping the measles virus‐specific cytokine responses in humans. J. Med. Virol. 82:1966–1975, 2010. © 2010 Wiley‐Liss, Inc.