bluuebunny/crossref_metadata_2025_split huggingface dataset:
Preterm delivery among female survivors of childhood, adolescent and young adulthood cancer
Authors: Madanat‐Harjuoja Laura‐Maria , Malila Nea , Lähteenmäki Päivi M. , Boice John D. , Gissler Mika , Dyba Tadeusz 
Published: January 2010

AbstractWe studied the deliveries of female cancer survivors and female siblings in a population‐based setting in Finland. Nationwide cancer and birth registries were merged to identify 1,309 first postdiagnosis deliveries of early‐onset (diagnosed under age 35) female patients with cancer and 5,916 first deliveries of female siblings occurring in 1987–2006. Multiple logistic regression models were used to estimate risk of preterm (<37 weeks), low birth weight (<2500 g) and small‐for‐gestational‐age deliveries. The risk of preterm delivery among cancer survivors compared with siblings was overall increased [odds ratio (OR) 1.46, 95% confidence interval (CI) 1.14–1.85], the increase in risk being visible in all diagnostic age groups. Risk of low birth weight (LBW) was also significantly increased (OR 1.68; 95% CI 1.29–2.18) but not after adjustment for duration of pregnancy (OR 1.11; 95% CI 0.76–1.64). Neither was the risk of small‐for‐gestational‐age (SGA) increased. The risk of preterm delivery was most pronounced in survivors delivering 10 years or more after diagnosis. Site‐specific analyses indicated that survivors of germ cell tumors and central nervous system (CNS) tumors were at increased risk of preterm delivery, although numbers were small. In childhood survivors, kidney tumors formed the main cause of preterm delivery. Pediatric, adolescent and young adult cancer survivors are at risk for preterm delivery. Heightened surveillance is recommended especially for Wilms', germ cell and CNS tumor survivors. Such adverse pregnancy outcomes can occur a decade or more after cancer diagnosis, indicating a continued need for obstetric awareness, surveillance and counseling in former patients with cancer.
The host defense peptide LL‐37 activates the tumor‐suppressing bone morphogenetic protein signaling via inhibition of proteasome in gastric cancer cells
Authors: Wu William Ka Kei , Sung Joseph Jao Yiu , To Ka Fai , Yu Le , Li Hai Tao , Li Zhi Jie , Chu Kin Man , Yu Jun , Cho Chi Hin 
Published: January 2010

AbstractThe human cathelicidin LL‐37, a pleiotropic host defense peptide, is down‐regulated in gastric adenocarcinomas. We therefore investigated whether this peptide suppresses gastric cancer growth. LL‐37 lowered gastric cancer cell proliferation and delayed G1‐S transition in vitro and inhibits the growth of gastric cancer xenograft in vivo. In this connection, LL‐37 increased the tumor‐suppressing bone morphogenetic protein (BMP) signaling, manifested as an increase in BMP4 expression and the subsequent Smad1/5 phosphorylation and the induction of p21Waf1/Cip1. The anti‐mitogenic effect, Smad1/5 phosphorylation, and p21Waf1/Cip1 up‐regulation induced by LL‐37 were reversed by the knockdown of BMP receptor II. The activation of BMP signaling was paralleled by the inhibition of chymotrypsin‐like and caspase‐like activity of proteasome. In this regard, proteasome inhibitor MG‐132 mimicked the effect of LL‐37 by up‐regulating BMP4 expression and Smad1/5 phosphorylation. Further analysis of clinical samples revealed that LL‐37 and p21Waf1/Cip1 mRNA expressions were both down‐regulated in gastric cancer tissues and their expressions were positively correlated. Collectively, we describe for the first time that LL‐37 inhibits gastric cancer cell proliferation through activation of BMP signaling via a proteasome‐dependent mechanism. This unique biological activity may open up novel therapeutic avenue for the treatment of gastric cancer. J. Cell. Physiol. 223: 178–186, 2010. © 2010 Wiley‐Liss, Inc.
Characterization of NaV1.6‐mediated Na+ currents in smooth muscle cells isolated from mouse vas deferens
Authors: Zhu Hai‐Lei , Shibata Atsushi , Inai Tetsuichiro , Nomura Masatoshi , Shibata Yosaburo , Brock James A , Teramoto Noriyoshi 
Published: January 2010

AbstractPatch‐clamp experiments were performed to investigate the behavior of voltage‐activated inward currents in vas deferens myocytes from NaV1.6‐null mice (NaV1.6−/−) lacking the expression of the Na+ channel gene, Scn8a, and their wild‐type littermates (NaV1.6+/+). Immunohistochemistry confirmed expression of NaV1.6 in the muscle of NaV1.6+/+, but not NaV1.6−/−, vas deferens. PCR analysis revealed that the only β1‐subunit gene expressed in NaV1.6+/+ vas deferens was Scn1b. In NaV1.6+/+ myocytes, the threshold for membrane currents evoked by 20 msec voltage ramps (−100 mV to 60 mV) was −38.5 ± 4.6 mV and this was shifted to a more positive potential (−31.2 ± 4.9 mV) by tetrodotoxin (TTX). In NaV1.6−/− myocytes, the threshold was −30.4 ± 3.4 mV and there was no TTX‐sensitive current. The Na+ current (INa) in NaV1.6+/+ myocytes had a bell‐shaped current–voltage relationship that peaked at approximately −10 mV. Increasing the duration of the voltage ramps beyond 20 msec reduced the peak amplitude of INa. INa displayed both fast (τ ∼10 msec) and slow (τ ∼1 sec) recovery from inactivation, the magnitude of the slow component increasing with the duration of the conditioning pulse (5–40 msec). During repetitive activation (5–40 msec pulses), INa declined at stimulation frequencies > 0.5 Hz and at 10 Hz ≤ 50% of the current remained. These findings indicate that INa is due solely to NaV1.6 in NaV1.6+/+ myocytes. The gating properties of these channels suggest they play a major role in regulating smooth muscle excitability, particularly in response to rapid depolarizing stimuli. J. Cell. Physiol. 223: 234–243, 2010. © 2010 Wiley‐Liss, Inc.
Return of FEV1 after pulmonary exacerbation in children with cystic fibrosis
Authors: Sanders Don B. , Hoffman Lucas R. , Emerson Julia , Gibson Ronald L. , Rosenfeld Margaret , Redding Gregory J. , Goss Christopher H. 
Published: January 2010

AbstractRationaleLung function (FEV1) generally improves during treatment of pulmonary exacerbations in patients with cystic fibrosis (CF). However, it is unclear how often return to previous baseline FEV1 is achieved.Objectives(1) To determine the proportion of pediatric patients with CF treated for a pulmonary exacerbation who fail to recover to baseline FEV1 and (2) to identify factors associated with this failure.MethodsWe performed a case–control analysis of patients from a single pediatric CF center admitted for their first pulmonary exacerbation in 2001–2006. Patients were considered to have recovered to baseline FEV1 if their best FEV1 within the 3 months following treatment was ≥95% of the best FEV1 during the 6 months prior to treatment. Logistic regression was used to estimate associations between clinical characteristics and failure to regain baseline FEV1.ResultsOf 104 patients, 24 (23.1%) did not recover to baseline FEV1. The adjusted odds ratio of failure to recover to baseline FEV1 was 1.49 (95% confidence interval [CI] 1.20, 1.86) for every 5% greater decline in FEV1 from baseline to admission. In exploratory analyses, the adjusted odds ratios for the failure to recover to baseline were also significantly higher for patients who were evaluated in our CF clinic more frequently between the baseline measurement and admission, were younger, or were insured by Medicaid.ConclusionsApproximately one in four patients with CF failed to recover to baseline lung function after a pulmonary exacerbation despite treatment with intravenous antibiotics. Failure to recover to baseline was associated with the degree of decline in FEV1 that had occurred prior to hospital admission, suggesting opportunities for earlier intervention to improve lung function outcomes. Additional studies are needed to determine how the failure to recover to baseline affects subsequent FEV1 decline. Pediatr Pulmonol. 2010; 45:127–134. © 2010 Wiley‐Liss, Inc.
Pulmonary squamous cell carcinoma associated with repaired congenital tracheoesophageal fistula and esophageal atresia
Authors: Esquibies Americo E. , Zambrano Eduardo , Ziai James , Kesebir Deniz , Touloukian Robert J. , Egan Marie E. , Reyes‐Múgica Miguel , Bazzy‐Asaad Alia 
Published: January 2010

AbstractWe report a 19‐year‐old man with pulmonary squamous cell carcinoma (SCC) who had a history of vertebral, anal, cardiac, tracheal, esophageal, renal, and radial limb defects (VACTERL) association and tracheoesophageal fistula (TEF) + esophageal atresia (EA) repair as an infant. Children that undergo TEF + EA repair may have an increased risk for developing cancer as they reach adulthood. Pediatr Pulmonol. 2010; 45:202–204. © 2010 Wiley‐Liss, Inc.
Cell phone intervention to improve adherence: Cystic fibrosis care team, patient, and parent perspectives
Authors: Marciel Kristen K. , Saiman Lisa , Quittell Lynne M. , Dawkins Kevin , Quittner Alexandra L. 
Published: January 2010

AbstractBackgroundTreatment regimens for patients with cystic fibrosis (CF) are time‐consuming and complex, resulting in consistently low adherence rates. To date, few studies have evaluated innovative technologies to improve adherence in this population. Current infection control guidelines for patients with CF seek to minimize patient‐to‐patient transmission of potential pathogens. Thus, interventions must avoid face‐to‐face contact and be delivered individually, limiting opportunities for peer support. This study aimed to develop and assess a web‐enabled cell phone, CFFONE™, designed to provide CF information and social support to improve adherence in adolescents with CF.MethodsThe acceptability, feasibility, and utility of CFFONE™ were evaluated with health care professionals (n = 17) adolescents with CF aged 11–18 years old (n = 12), adults with CF aged 21–36 years old (n = 6), parents of adolescents with CF (n = 12), and technology experts (n = 8). Adolescents also tested a prototype of CFFONE™ (n = 9). Qualitative and quantitative data were collected.ResultsFocus group data with health care professionals indicated a need for this intervention, and indicated that CFFONE™ would be likely to improve knowledge and social support, and somewhat likely to improve adherence. Adolescent, adults, and parents all rated CFFONE™ as likely to improve adherence. Technology experts rated the prototype design and format as appropriate.ConclusionsThe current study provided some support from key stakeholders for this intervention to improve adherence in adolescents with CF. Next steps include a multi‐center trial of the efficacy and safety of CFFONE™. Pediatr Pulmonol. 2010; 45:157–164. © 2010 Wiley‐Liss, Inc.
Expression of toll‐like receptor‐9 is increased in poorly differentiated prostate tumors
Authors: Väisänen Marja‐Riitta , Väisänen Timo , Jukkola‐Vuorinen Arja , Vuopala Katri S. , Desmond Renee , Selander Katri S. , Vaarala Markku H. 
Published: January 2010

AbstractBACKGROUNDToll‐like receptor‐9 (TLR9) is a cellular receptor for bacterial and vertebrate DNA. In addition to cells of the immune system, it is also expressed in various human cancer cell lines, including prostate cancer. We demonstrated previously that synthetic TLR9 ligands induce matrix metalloproteinase‐13‐mediated invasion in TLR9‐expressing prostate cancer cells in vitro. Other studies have suggested possible sex steroid regulation of the function of the various TLRs. The role of TLR9 in the pathophysiology of prostate or any cancer is, however, unknown.METHODSExpression of TLR9, androgen receptor (AR), or the estrogen receptors α (ERα) and β (ERβ) were studied with immunohistochemistry in prostate cancer (n = 62) and benign prostatic hyperplasia (n = 45) specimens. TLR9 staining scores were compared with tumor stage, Gleason score, prostate‐specific antigen (PSA) concentrations before tissue sampling and with the staining scores of AR, ERα, and ERβ.RESULTSTLR9 expression was statistically significantly increased in prostate cancer epithelium and stroma, as compared with the same cellular compartments in benign hyperplasia. Significantly increased (P = 0.04) TLR9 expression was detected in cancers with high Gleason score (>7, n = 23), as compared with lower Gleason scores (≤7, n = 39). No statistically significant associations were detected between TLR9 expression scores and PSA concentrations or tumor staging. Prostate adenocarcinoma cells were all positive for TLR9, AR, and ERβ but negative for ERα expression. In cancer stroma cells, increased TLR9 expression was associated with increased ERα expression.CONCLUSIONSExpression of TLR9 is increased in prostate cancer specimens, especially in the most poorly differentiated forms. Prostate 70: 817–824, 2010. © 2010 Wiley‐Liss, Inc.
Meta‐Analysis of Survival of Patients with Stage IV Colorectal Cancer Managed with Surgical Resection Versus Chemotherapy Alone
Authors: Stillwell A. P. , Buettner P. G. , Ho Y‐H. 
Published: January 2010

AbstractBackgroundThere is no consensus regarding the appropriate management of asymptomatic and minimally symptomatic patients with stage IV colorectal cancer and irresectable metastases.MethodsA literature search was conducted on Medline and Embase. Outcome measures included: survival; postoperative morbidity and mortality; complications from the primary tumor and the need for surgery to manage complications; the likelihood of curative surgery after initial response to primary therapy; and length of hospital stay. Quantitative meta‐analysis was performed where appropriate.ResultsEight retrospective studies, including 1,062 patients, met the criteria for inclusion in this study. Meta‐analysis has shown an improvement in the survival of patients managed with palliative resection of their primary tumor, with an estimated standardized median difference of 6.0 months (standardized difference, 0.55; 95% confidence interval (CI), 0.29, 0.82; p < 0.001). Patients managed with chemotherapy alone were 7.3 times more likely to have a complication from the primary tumor (95% CI, 1.7, 34.4; p = 0.008). There was no difference in the response rates to chemotherapy, making metastatic disease amendable to curative resection (0.85; 95% CI 0.40, 1.8; p = 0.662).ConclusionsTo date, only retrospective data are available, showing that palliative resection of the primary tumor in asymptomatic or minimally symptomatic patients with stage IV colorectal cancer is associated with longer survival. Resection of the primary tumor reduces the likelihood of complications from the primary tumor and avoids the need for emergency procedures.
Feeding activity pattern in a parasitic wasp when foraging in the field
Authors: Desouhant Emmanuel , Lucchetta Patrice , Giron David , Bernstein Carlos 
Published: January 2010

AbstractIndividual decision‐making and behavioral plasticity, and hence reproductive success, depend on nutritional state. Despite the importance of food for life‐history functions, when and how often parasitoids encounter and consume food in natural settings remain largely unknown. In this study, we aimed at determining the food intake history of theVenturia canescensparasitoids in field conditions. To fulfill this objective, we compared the nutritional state of lab individuals of known feeding history and of field‐released individuals allowed to freely forage under natural conditions. Nutritional state and feeding history were determined by using a combination of physiological parameters based on sugar assays. Field‐released wasps were caught during periods starting either 5 or 24 h after release. Our results show that in the field, the wasps search actively for carbohydrate food sources. Our work also indicates that feeding activity of wasps in the field can be better understood by using the combination of key physiological parameters. The adaptive value of the feeding pattern and the relevance of the approach used are discussed.
The 14-item Paediatric Throat Disorders Outcome Test: a valid, sensitive, reliable, parent-reported outcome measure for paediatric throat disorders
Authors: Hopkins C , Fairley J , Yung M , Hore I , Balasubramaniam S , Haggard M 
Published: January 2010

AbstractObjectives:We modified and abbreviated a pre-existing research questionnaire, the Tonsil and Adenoid Health Status Instrument, to make it suitable for rapid completion as a disease-specific, health-related quality of life research tool for children with tonsil and adenoid disease in the UK. We determined the main psychometric properties of the resulting 14-item Paediatric Throat Disorders Outcome Test.Design, setting and participants:Pre- and post-operative questionnaires were completed by the parents of children with throat disorders referred to two large hospitals. We included children with recurrent tonsillitis and with obstructive sleep apnoea. A separate cohort of healthy children of comparable age range was also studied.Main outcome measures:The test's internal consistency and responsiveness were analysed and its construct validity documented via known-group differences.Results:A total of 126 completed questionnaires were received from the hospital referral group. The children's mean age was 6.5 years (range one to 16). The 40 unaffected children were well matched in age to the study population (mean 6.1 years, range two to 15). Cronbach's α coefficient for the pre-operative assessment total score was 0.84. The test–retest reliability coefficient for the total score was 0.98, indicating very high reproducibility. The 14-item Paediatric Throat Disorders Outcome Test discriminated well between children known to suffer with throat problems and a group of healthy controls (p < 0.0001; t = 24.016). Six months after surgical intervention, parentally reported questionnaire scores had improved (i.e. were lower) (p < 0.0001; t = 7.01). The standard effect size (i.e. change in mean divided by baseline standard deviation) for children for whom post-operative questionnaires were completed was 1.53; this is very large.Conclusions:The 14-item Paediatric Throat Disorders Outcome Test is an appropriate, disease-specific, parent-reported outcome measure for children with throat disorders, for which we have demonstrated internal consistency, reliability, responsiveness to change and two forms of construct validity.
The Works of Bhasa
Authors: Sastri T. Ganapati 
Published: January 2010

In the Bulletin of the School of Oriental Studies, London, at pp. 107 to 117 of III, 1, are to be found some criticisms by Messrs. Krishna Pishāroḍi and Rama Pishāroḍi on my views of Bhāsa and his authorship of Svapna-Vāsavadatta and the connected dramas published in the Trivandrum Sanskrit Series. Their arguments are summarized hereunder with replies thereto:—I. “Every open-minded critic must perforce admit that Pratimā-nāṭaka must come after Kālidāsa, Chārudatta after Śūdraka, and Avimāraka after Daṇḍin.”
Bārgīrī
Authors: Bivar A. D. H. 
Published: January 2010

Bārgīrī is a New Persian term seemingly of transparent meaning: ‘the taking up of loads’. As such, it is listed by Steingass, with various special meanings ‘Conviction, criminal charge; taking-in of a ship's cargo’, none of which covers its full, or perhaps most important, semantic range. Moreover, the word is of note both for its relation to the nomadic life-style, and its interest to Orientalist scholarship. It seems worth collecting the references to provide a wider setting.Leyla Azami (sister of the Iranian folklorist, Cheragh Ali Azami), recently discussed the word in connexion with the transhumant life of the Sangsarī tribe in the south-eastern Elburz. Here it is defined as tahiya-i muqaddamāt-i safar ‘the preparation of the preliminaries for a journey’, events which take place ‘in the third decade of the month of Urdibihisht’—the second month of the Iranian calendar, April–May, when the pastoralists assemble, preparing for their move to high ground with the advent of spring.
British Orientalists' co-operation: a new letter of Sir William Jones
Authors: Cannon Garland , Grout Andrew 
Published: January 2010

The purpose of this Note is to make available to scholars the text of a new letter by Sir William Jones (1746–94) to Richard Johnson (1753–1807), recently discovered in an antiquarian book and manuscript catalogue issued in 1924 by Maggs Brothers, the London dealers, and otherwise unpublished and unrecorded.Johnson, an important though neglected figure in the history of the British ‘discovery’ of Hinduism, held a number of influential posts within the East India Company's administration during his sojourn in India from 1770 to 1790. But it is for his investigations into Indian literature and music, including his substantial and important collection of Indian miniatures and Persian and Sanskrit manuscripts, that he deserves to be better known.
Dahma Āfriti and some related problems
Authors: Boyce Mary 
Published: January 2010

The Yazata of the benediction known as the Dahma Āfriti is a figure whose importance in the Zoroastrian pantheon has been obscured, it seems for two main reasons. One is that, although she was apparently originally accorded a place among the thirty ‘calendar’ divinities, she subsequently lost this, probably in an Achaemenian calendar reform. The other is that later still her identity became confused through her name acquiring several Middle Persian forms: Dahm Yazad, Dahmān Āfrīn, Dahmān, the last, since it is a formal plural, causing some misunderstandings in her veneration locally.The Avestan adjectivedahmais understood to have meant originally ‘instructed’, that is, in the Zoroastrian faith; but, to judge from its use in context, it developed the sense of ‘pious, devout’, occurring frequently withašavanas a term for a good Zoroastrian. The name of the benediction is accordingly generally rendered as the ‘Pious Blessing’. Much power was attributed by Zoroastrians to solemnly pronounced words, and the compilers of the extendedyasnaliturgy set the ‘Pious Good Blessing’,Dahṃa VaohviĀfriti, after theAhuna Vairya, Ašəm VohūandYenhē hātąmas the fourth of the mighty utterances which crush and destroy Anra Mainyu and his hordes (Y.61:l–2). (The other three form a group because together they precede theGāthās, and together are the subject of the commentary which forms (Y. 19–21.)
Translating the ancestors: S. I. J. Schereschewsky's 1875 Chinese version of Genesis
Authors: Eber Irene 
Published: January 2010

Partial and complete Bible translations into classical Chinese existed well before Protestant missionaries actually began to work actively among the Chinese. Translation work accelerated once missionaries gained a foothold in the newly opened treaty ports after 1842, and the entire Bible or portions of it were translated into Fuzhou, Amoy, Canton, Hakka, Suzhou, Ningbo and Shanghai dialects. S. I. J. Schereschewsky's (1831–1906) translation of the Old Testament (OT) into the northern vernacular in 1875 opened a new chapter. His translation was accessible to larger numbers of people and, in contrast to the OT in classical Chinese, was readily understood when read to the illiterate. Moreover, unlike previous translations, it was prepared entirely from the Hebrew original.The purpose of this essay is to examine some of Schereschewsky's views on translating and several of the techniques which he employed in rendering into Chinese the Book of Genesis. My basic assumption is that translation is an interpretative activity. When a text is transposed from one language into another, changes are introduced that are consonant with the receiving languages and culture. Translation is affected by interpretations from within the receptor tradition which, in turn, makes possible the acceptance of the translation and the ideas which it contains. Thus the Old (as well as the New) Testament translations represented one of the initial steps in the signification of Protestant Christianity.