bluuebunny/crossref_metadata_2025_split huggingface dataset:
Local existence and global boundedness for a chemotaxis system with gradient dependent flux limitation
Authors: Li Yuxiang , Yan Jianlu 
Published: May 2024

In this paper, we investigate the following Keller–Segel system with flux limitation [Formula: see text] under no-flux boundary conditions in a ball [Formula: see text]), where [Formula: see text] is positive and [Formula: see text] with [Formula: see text]. It is proved that the problem (⋆) possesses a unique classical solution that can be extended in time up to a maximal [Formula: see text]. Moreover, it is shown that the above solution is global and bounded when either [Formula: see text] if [Formula: see text] and [Formula: see text], or [Formula: see text] if [Formula: see text] and [Formula: see text]. We point out that when [Formula: see text], our result is consistent with that of [N. Bellomo and M. Winkler, Comm. Partial Differential Equations 42 (2017) 436–473].
INVESTIGATION ON ABRASIVE WATER JET DRILLING HOLE FEATURES OF UHMWPE
Authors: SUBRAMANI K. , RATHINASURIYAN C. 
Published: May 2024

Ultra-high molecular-weight polyethylene (UHMWPE) is one of the most extensively utilized supporting materials inside total knee replacement (TKR) because of its combination of outstanding mechanical qualities and wear resistance. The integrity of the hole is an essential component for fastening the femur and tibia elements in knee replacements. Due to its viscoelasticity behavior, it often causes difficulties such as rapid tool wear, burr formation, and poor finish in conventional machining operations, which causes poor hole features. Since unconventional methods are currently being investigated for drilling UHMWPE. Abrasive water jet drilling (AWJD) is particularly promising for handling hard-to-machine materials, and AWJ drilling of UHMWPE materials demands focus on it. The focus of this research is to determine the importance of AWJD variables for UHMWPE. In this experiment, 64 holes, each with a diameter of 10[Formula: see text]mm, were drilled into the sample material using a complete factorial approach to evaluation. Abrasive water jet pressure (AWJP) (210, 260, 310, and 360[Formula: see text]MPa), abrasive mass flow rate (AMFR) (250, 300, 350, and 400[Formula: see text]g/min.), and traverse rate (TR) (150, 300, 450, and 600[Formula: see text]mm/min.) were all taken into account. Furthermore, the geometrical properties of the hole, such as hole diameter (entry and exit), circularity, perpendicularity, and cylindricity, were investigated. The outcomes identified that both AWJP and TR played significant roles in determining the geometric features of the hole. During the drilling operation, the material removal mechanism and the hole defects were observed and identified using scanning electron microscopy (SEM).
Influence of TiO2 Nanoparticles on Enhancing the Properties Activity of Organic Polymeric Materials for Industrial Applications
Authors: Alotaibi B. M. , Alyousef Haifa A. , Atta A. , Rizk S. A. , Elgendy Abdelfattah T. 
Published: May 2024

Novel composite (MC/TiO2) films consisting of titanium dioxide nanoparticles (TiO2NPs) and organic polymer methylcellulose (MC), were synthesized for applied in photocatalysis and industrial sectors. The preparation of the nanocomposites MC/TiO2 films were verified successfully by EDX technique, which demonstrated the uniform distribution of TiO2 in the MC. Moreover, in frequency of 20 Hz to 5.5 MHz, the dielectric properties of MC as a function of TiO2 concentration were determined. The conductivity improved from 5.8 × 10−8 S.cm−1 for MC to 3.8 × 10−6 S.cm−1 for the composite MC/TiO2, and the dielectric constant

ε

′

has risen from 87 for MC to 179 for the composite MC/TiO2. In addition, the energy density increases from 3.86 × 10−4 J m−3 for MC to 7.94 × 10−4 J m−3 for MC/TiO2, and the relaxation time

τ

r

dropped from 11.5 × 10−5 sec to 2.58 × 10−5. In summary, the data investigated that the dielectric characteristics of MC/TiO2 were modified for usage in different applications as wastewater treatment and energy storage devices.
Ultrasound-Guided Quantitative Fluorescence Molecular Endoscopy for Monitoring Response in Patients with Esophageal Cancer Following Neoadjuvant Chemoradiotherapy
Authors: Schmidt Iris , Zhao Xiaojuan , van der Waaij Anne M. , Meersma Gert Jan , Dijkstra Frederieke A. , Haveman Jan Willem , van Etten Boudewijn , Robinson Dominic J. , Kats-Ugurlu Gursah , Nagengast Wouter B. 
Published: May 2024

Abstract

Purpose:
The ability to identify residual tumor tissues in patients with locally advanced esophageal cancer following neoadjuvant chemoradiotherapy (nCRT) is essential for monitoring the treatment response. Using the fluorescent tracer bevacizumab-800CW, we evaluated whether ultrasound-guided quantitative fluorescent molecular endoscopy (US-qFME), which combines quantitative fluorescence molecular endoscopy (qFME) with ultrasound-guided needle biopsy/single-fiber fluorescence (USNB/SFF), can be used to identify residual tumor tissues in patients following nCRT.

Experimental Design:
Twenty patients received an additional endoscopy procedure the day before surgery. qFME was performed at the primary tumor site (PTS) and in healthy tissue to first establish the optimal tracer dose. USNB/SFF was then used to measure intrinsic fluorescence in the deeper PTS layers and lymph nodes (LN) suspected for metastasis. Finally, the intrinsic fluorescence and the tissue optical properties—specifically, the absorption and reduced scattering coefficients—were combined into a new parameter called omega.

Results:
First, a 25-mg bevacizumab-800CW dose allowed for clear differentiation between the PTS and healthy tissue, with a target-to-background ratio (TBR) of 2.98 (IQR, 1.86–3.03). Moreover, we found a clear difference between the deeper esophageal PTS layers and suspected LN compared to healthy tissues, with TBR values of 2.18 and 2.17, respectively. Finally, our new parameter, omega, further improved the ability to differentiate between the PTS and healthy tissue.

Conclusions:
Combining bevacizumab-800CW with US-qFME may serve as a viable strategy for monitoring the response to nCRT in esophageal cancer and may help stratify patients regarding active surveillance versus surgery.
Glutamatergic neurotransmission in schizophrenia: A systematic review and quantitative synthesis of proton magnetic resonance spectroscopy studies across schizophrenia spectrum disorders
Authors: Lopes Jamie J , Carruthers Sean P , Meyer Denny , Dean Brian , Rossell Susan L 
Published: May 2024

Objective: Studies using proton magnetic resonance spectroscopy reveal substantial inconsistencies in the levels of brain glutamate, glutamine and glutamate + glutamine across schizophrenia spectrum disorders. This systematic review employs qualitative and quantitative methods to analyse the patterns and relationships between glutamatergic metabolites, schizophrenia spectrum disorders and brain regions. Methods: A literature search was conducted using various databases with keywords including glutamate, glutamine, schizophrenia, psychosis and proton magnetic resonance spectroscopy. Inclusion criteria were limited to case-control studies that reported glutamatergic metabolite levels in adult patients with a schizophrenia spectrum disorder diagnosis – i.e. first-episode psychosis, schizophrenia, treatment-resistant schizophrenia and/or ultra-treatment-resistant schizophrenia – using proton magnetic resonance spectroscopy at 3 T or above. Pooled study data were synthesized and analysed. Results: A total of 92 studies met the inclusion criteria, including 2721 healthy controls and 2822 schizophrenia spectrum disorder participants. Glu levels were higher in the basal ganglia, frontal cortex and medial prefrontal of first-episode psychosis participants, contrasting overall lower levels in schizophrenia participants. For Gln, strong differences in metabolite levels were evident in the basal ganglia, dorsolateral prefrontal cortex and frontal cortex, with first-episode psychosis showing significantly higher levels in the basal ganglia. In glutamate + glutamine, higher metabolite levels were found across schizophrenia spectrum disorder groups, particularly in the basal ganglia and dorsolateral prefrontal cortex of treatment-resistant schizophrenia participants. Significant relationships were found between metabolite levels and medication status, clinical measures and methodological variables. Conclusion: The review highlights abnormal glutamatergic metabolite levels throughout schizophrenia spectrum disorders and in specific brain regions. The review underscores the importance of standardized future research assessing glutamatergic metabolites using proton magnetic resonance spectroscopy due to considerable literature heterogeneity.
A Longitudinal Investigation of Nasolabial Changes With and Without Revision Surgery in Patients with Non-Syndromic Unilateral Cleft Lip and Palate
Authors: Dabbagh Wasna , Groff Destin , Stauffer Lexi , Newland Mary , Lo Alexis , Hiller Andrea , Long Ross E 
Published: May 2024

Objective To determine a baseline of anticipated change in nasolabial appearance following primary repair of unilateral cleft lip/palate and evaluate the degree to which revision surgery improves nasolabial appearance. Design Retrospective chart review. Setting Patients treated at the Lancaster Cleft Palate Clinic interdisciplinary clinic. Patients Twenty-three patients with complete unilateral cleft lip and palate who underwent primary surgical repair and 19 additional patients who underwent subsequent revision surgery were included. Interventions Patients in the non-revision group underwent a Tennison-Randall triangular flap lip repair at 3mo. Patients in the revision group underwent a modification of the Nakajima straight-line repair after primary Tennison-Randall triangular flap lip repair at an average age of 141mo. Main Outcome Measures A modification of the Asher-McDade Aesthetic Index was utilized to evaluate Nasolabial Frontal (NLF), Nasolabial Profile (NLP), Vermillion Border (VB), and total change in appearance. Scores for patients in the revision group were evaluated before and after revision while appearance for patients without revision was evaluated at 3 distinct ages. Scores were averaged across time-points and inter-rater reliability was assessed. Results Nasolabial appearance in the non-revision sample did not change significantly over time, except for nasal profile. Scores improved after revision surgery – NLP: 3.48 to 2.97, (p = 0.001); NLF: 3.50 to 2.95 (p = 0.001); and Total Nasolabial Score: 3.29 to 3.01 (p = 0.004), with no significant change in VB. Conclusion Decisions regarding need for nasolabial revision surgery may be made as early as 5yo with successful outcomes following secondary surgery improving appearance except for vermillion border appearance.
A Qualitative Investigation of Factors Influencing the Integration of Complementary and Integrative Healthcare Recommendations in the Daily Lives of Patients with Cancer
Authors: Dürsch Helena , Boltenhagen Ursula , Mahler Cornelia , Joos Stefanie , Joachim Szecsenyi , Klafke Nadja 
Published: May 2024

Background: Many patients diagnosed with cancer use complementary and integrative healthcare (CIH) approaches to manage their cancer- and treatment-related symptoms and improve their well-being. Evidence suggests that counseling on CIH can improve health outcomes and decrease healthcare costs by increasing patient activation. This qualitative study explores the experiences of cancer patients who underwent interprofessional counseling on CIH to gain insights into how these patients were able to integrate recommended CIH measures into their daily lives while undergoing conventional cancer treatment. Methods: Forty semi-structured interviews were conducted with cancer patients participating in the CCC-Integrativ study and its process evaluation. The interviews were audio-recorded, transcribed verbatim, and analyzed using content analysis following Kuckartz and Rädiker. A purposeful sampling strategy was used to achieve a balanced sample regarding gender, age, cancer diagnosis, and treatment approach. Results: Most patients with cancer reported largely implementing the CIH recommendations. Participants acknowledged the efficacy of CIH recommendations in managing their symptoms. They felt strengthened and empowered to actively take part in their healthcare decisions. However, the patients encountered obstacles in incorporating the recommended CIH applications into their daily routines. These challenges encompassed the effort required for treatment application (e.g., baths, compresses), limitations imposed by the cancer disease (e.g., fatigue, pain), difficulties acquiring necessary materials, associated costs, and lack of infrastructure for CIH. Facilitators of CIH implementation included the availability of easily manageable CIH measures (e.g., herbal teas), informative materials on their application, distribution of samples, family support, and a high level of self-efficacy. The patient-centered approach and strong patient-provider partnership within the counseling context were perceived as empowering. Participants expressed a desire for a consistent point of contact to address their CIH concerns. Conclusions: The findings underscore the benefits of CIH counseling for cancer patients’ symptom management and overall well-being. Healthcare professionals providing CIH counseling to patients with cancer may recognize the barriers identified to better support their patients in the regular use of CIH.
Effort-reward imbalance and common mental disorders among public sector employees of Iran: a cross-sectional analysis
Authors: Nasirpour Nastaran , Shalbafan Mohammadreza , Savari Ebtesam , Pirani Ahmad , Baradaran Hamid Reza , Motevalian Abbas 
Published: May 2024

Abstract
Background
The effort-reward imbalance (ERI) model is a widely used theoretical model to measure stress in the workplace. The objective of this study was to investigate the relationship between ERI and three common mental disorders: major depressive disorder (MDD), generalized anxiety disorder (GAD), and obsessive-compulsive disorder (OCD).

Methods
In this cross-sectional analysis, the study sample consisted of 4453 baseline participants of the Employees’ Health Cohort Study of Iran (EHCSIR). Trained psychologists utilized the Persian version of the Composite International Diagnostic Interview (CIDI-2.1) during the baseline assessment to identify common mental disorders. Additionally, the validated Persian version of the 23-item ERI questionnaire was employed to assess effort, reward, overcommitment, and effort-reward ratio. To examine the association of ERI components with three common mental disorders (MDD, GAD, and OCD) over the past twelve months, multiple logistic regression analyses were conducted.

Results
The prevalence of effort-reward imbalance in the study sample was 47.1%. Higher ERI score was significantly associated with MDD (OR: 3.43, 95% CI: 2.30–5.13), GAD (OR: 2.42, 95% CI: 1.27–4.63), and OCD (OR: 2.23, 95% CI:1.19–4.19). The study participants who reported higher scores on work overcommitment had a higher likelihood of having MDD (OR: 1.16, 95% CI:1.10–1.23), GAD (OR: 1.07, 95% CI: 1.01–1.14), and OCD (OR: 1.19, 95% CI: 1.09–1.29).

Conclusions
According to the study’s findings, work-related stress, as determined by the ERI model, is a significant factor in the development of common mental disorders among employees in the public sector.
Barriers and outcomes of therapeutic communication between nurses and patients in Africa: a scoping review
Authors: Abraham Susanna Aba , Nsatimba Frederick , Agyare Dorcas Frempomaa , Agyeiwaa Joyce , Opoku-Danso Rita , Ninnoni Jerry Paul , Doe Patience Fakornam , Kuffour Benjamin Osei , Anumel Benjamin Kofi , Berchie Gifty Osei , Boso Christian Makafui , Druye Andrews Agyei , Okantey Christiana , Owusu Gifty , Obeng Paul , Amoadu Mustapha , Commey Isaac Tetteh 
Published: May 2024

Abstract
Background
Therapeutic communication (TC) promotes effective patient care, emotional wellbeing, and improves patient outcomes. The purpose of this review was to synthesise evidence on barriers and outcomes of TC between nurses and patients in Africa and to inform future studies and systematic reviews.

Methods
Search for the records was done in four major databases including PubMed, Science Direct, PubMed CENTRAL, and JSTOR. Additional searches were done in Google Scholar and Google. Results and findings from published studies and grey literature were included. A total of 16 articles met the eligibility criteria and were included in the review. This scoping review followed the guidelines by Askey and O’Malley.

Results
Barriers associated with TC were grouped under five main themes: sociodemographic factors, patient-related factors, nurse-related factors, environmental and health service-related. Age, and religious beliefs were the main sociodemographic factors that hindered TC while stress and inadequate knowledge and skills were identified among the nurse-related barriers to TC. Extreme weather conditions and mosquito infestation were environmental factors while lack of access to TC educational programmes on TC was a health service-related factor that interfered with TC. Both positive and negative outcomes of TC were also identified.

Conclusion
Continuous professional development on TC is necessary to improve nurses’ attitudes and update their skills to enable them to render culturally competent nursing care to patients.
Person-centred care and the work-related health and job satisfaction of health and social care professionals: protocol for a prospective longitudinal cohort study combined with qualitative studies (the PCC@Work project)
Authors: van Diepen Cornelia , Lood Qarin , Gustavsson Kristoffer , Axelsson Malin , Bertilsson Monica , Hensing Gunnel , Fors Andreas 
Published: May 2024

Abstract
Background
The interplay of ethical stress, heavy workloads, and job dissatisfaction poses challenges to both the recruitment and retention of health and social care professionals. Person-centred care, rooted in ethical principles, involves collaborative care, and is expected to improve care and job satisfaction. However, prior research on the impact of person-centred care practices on professionals’ work-related health and job satisfaction has yielded mixed results, and most studies emanate from residential care. Understanding how person-centred care practices influence health and social care professionals across different care settings thus requires further exploration through rigorous methodology. The overall aim of PCC@Work is to follow, describe, assess, and explore the impact of person-centred care practices in hospital wards, primary care centres and municipal care on health and social care professionals’ work-related health and job satisfaction.

Methods
PCC@Work is designed as a prospective, longitudinal cohort study combined with qualitative studies. A web-based questionnaire will be distributed on five occasions within two years to health and social care professionals in the three care settings. In addition, focus groups and interviews will be conducted with a selection of health and social care professionals to explore their experiences of work-related health and job satisfaction in relation to person-centred practices.

Discussion
PCC@Work will highlight some of the knowledge gaps on the impact of person-centred care practices regarding work-related health and job satisfaction of health and social care professionals. The uniqueness of the project lies in the multi-method design, combining a prospective longitudinal cohort study with qualitative studies, and the involvement of various professions and settings. This means we will be able to provide a comprehensive and representative understanding of person-centred care practices as a critical component for effective change in the working conditions of health and social care.
msBERT-Promoter: a multi-scale ensemble predictor based on BERT pre-trained model for the two-stage prediction of DNA promoters and their strengths
Authors: Li Yazi , Wei Xiaoman , Yang Qinglin , Xiong An , Li Xingfeng , Zou Quan , Cui Feifei , Zhang Zilong 
Published: May 2024

Abstract
Background
A promoter is a specific sequence in DNA that has transcriptional regulatory functions, playing a role in initiating gene expression. Identifying promoters and their strengths can provide valuable information related to human diseases. In recent years, computational methods have gained prominence as an effective means for identifying promoter, offering a more efficient alternative to labor-intensive biological approaches.

Results
In this study, a two-stage integrated predictor called “msBERT-Promoter” is proposed for identifying promoters and predicting their strengths. The model incorporates multi-scale sequence information through a tokenization strategy and fine-tunes the DNABERT model. Soft voting is then used to fuse the multi-scale information, effectively addressing the issue of insufficient DNA sequence information extraction in traditional models. To the best of our knowledge, this is the first time an integrated approach has been used in the DNABERT model for promoter identification and strength prediction. Our model achieves accuracy rates of 96.2% for promoter identification and 79.8% for promoter strength prediction, significantly outperforming existing methods. Furthermore, through attention mechanism analysis, we demonstrate that our model can effectively combine local and global sequence information, enhancing its interpretability.

Conclusions
msBERT-Promoter provides an effective tool that successfully captures sequence-related attributes of DNA promoters and can accurately identify promoters and predict their strengths. This work paves a new path for the application of artificial intelligence in traditional biology.
Extensive remodeling of sugar metabolism through gene loss and horizontal gene transfer in a eukaryotic lineage
Authors: Pontes Ana , Paraíso Francisca , Silva Margarida , Lagoas Catarina , Aires Andreia , Brito Patrícia H. , Rosa Carlos A. , Lachance Marc-André , Sampaio José Paulo , Gonçalves Carla , Gonçalves Paula 
Published: May 2024

AbstractBackgroundIn yeasts belonging to the subphylum Saccharomycotina, genes encoding components of the main metabolic pathways, like alcoholic fermentation, are usually conserved. However, in fructophilic species belonging to the floralWickerhamiellaandStarmerellagenera (W/S clade), alcoholic fermentation was uniquely shaped by events of gene loss and horizontal gene transfer (HGT).ResultsBecause HGT and gene losses were first identified when only eight W/S-clade genomes were available, we collected publicly available genome data and sequenced the genomes of 36 additional species. A total of 63 genomes, representing most of the species described in the clade, were included in the analyses. Firstly, we inferred the phylogenomic tree of the clade and inspected the genomes for the presence of HGT-derived genes involved in fructophily and alcoholic fermentation. We predicted nine independent HGT events and several instances of secondary loss pertaining to both pathways. To investigate the possible links between gene loss and acquisition events and evolution of sugar metabolism, we conducted phenotypic characterization of 42 W/S-clade species including estimates of sugar consumption rates and fermentation byproduct formation. In some instances, the reconciliation of genotypes and phenotypes yielded unexpected results, such as the discovery of fructophily in the absence of the cornerstone gene (FFZ1) and robust alcoholic fermentation in the absence of the respective canonical pathway.ConclusionsThese observations suggest that reinstatement of alcoholic fermentation in the W/S clade triggered a surge of innovation that goes beyond the utilization of xenologous enzymes, with fructose metabolism playing a key role.