bluuebunny/crossref_metadata_2025_split huggingface dataset:
Métaphysique et poésie: une admirable concordia discors ?
Authors: Chenet François 
Published: February 2012

Résumé La question des rapports entre philosophie et poésie n’a cessé de solliciter la réflexion comme s’il y avait entre elles affinité et hostilité secrètes. Qu’en est-il du rapport sans séparation ni confusion entre philosophie et poésie ? Penseurs et poètes peuvent-ils se rencontrer ? Et quels sont les voies et moyens de leur possible conciliation ? L’affinité secrète entre métaphysique et poésie est d’abord élucidée à la lumière de la philosophie de Schelling. Il est ensuite fait droit à la secrète hostilité entre poésie et philosophie en se référant à la conception du poète et penseur Yves Bonnefoy. Enfin sont explorées les voies d’une conciliation par l’analyse de l’intuition créatrice dans l’art et la poésie développée par Jacques Maritain, et par la conception de la « fonction Méta » proposée par Stanislas B reton. En définitive, il se pourrait que la poésie aille plus loin que la métaphysique, ainsi que le proclama R. W. Emerson célébrant l’office de la poésie et n’hésitant pas à comparer le Poète au Créateur.
La pensée de Claudel : la poësie intégrale
Authors: Caron Maxence 
Published: February 2012

Résumé Claudel est le « poëte » de la présence de la Vérité, pour qui la « poësie » est manifestation musicale de la pensée. Le poëte chante la présence dans le monde de la Cause du monde, présence transcendante au monde, mais médiatisée, à la différence du divin de Hölderlin. L’Absolu n’est pas muet, il parle par le Christ, présent dans l’Église par l’eucharistie. De là vient l’idée d’une « poësie intégrale ». Contre la voie de l’apophatisme, Claudel invoque la co-naissance de l’homme et de Dieu. Le poëte est l’homme de l’être, fidèle à Mnémosyne, la mère des Muses, qui est la grâce. Claudel est conscient que ses œuvres sont et seront méconnues en raison de l’ontologie et de l’exégèse biblique qui les nourrissent.
Prionocera revisited (Diptera: Tipulidae)
Authors: Brodo Fenja 
Published: February 2012

AbstractThe synonymy of Prionocera chosenicola Alexander with Prionocera tjederi Mannheims is discussed and the following syn. nov. is proposed: Prionocera mannheimsi Savchenko = Prionocera byersi Brodo. Prionocera parrii (Kirby) remains a nomen dubium. Significant range extensions are noted for Prionocera dimidiata (Loew), Prionocera ominosa (Alexander), Prionocera oregonica Alexander, Prionocera pubescens Loew, Prionocera ringdahli Tjeder, Prionocera serricornis (Zetterstedt), Prionocera subserricornis (Zetterstedt), and Prionocera turcica (Fabricius).
Binge Drinking and Psychoactive Drug use in a Cohort of European Youths
Authors: Siliquini Roberta , Colombo Alessandra , Berchialla Paola , Bert Fabrizio ,   TEN-D Group, Alamar B. , Alonso F. , Calatayud C. , Carena F. , Piat S. Chiadò , Chiapusso T. ,   CONSEPI group, Druart A. , Duce M.T. , Esteban C. , Izzicupo C. , Kalitowicz Ag. , Kalitowicz An. , Kedzia M. , Manassero G. , Pignata E. , Papalia R. , Pudule I. , Sànchez L. , Siliquini R. , Siliquini V. , Sroka R. , Vankov D. , Vanzino S. , Villerusa A. 
Published: February 2012

Background TEN-D by Night is an international, multicentre, cross-sectional portal survey conducted on a large sample of young people in six European countries. This paper aims to investigate the alcohol and psychoactive drug consumption of this sample, with a focus on the prevalence of binge drinking and the poly-drug habits of the TEN-D cohort. Design and Methods The study population consisted of 4695 young people attending recreational sites on weekend nights. The intervention included two questionnaires and two psychoactive substance detection tests performed at the entry and exit of the recreational sites. A multivariate logistic regression model was used to predict the probability of binge drinking. Results Binge drinking was reported by 20% of the males and 13% of the females (P=0.001) before entry into the recreational sites and by 18% of the males and 11% of the females before entry into the clubs (P<0.001). Poly-drug use was reported by 71% of the males and 66% of the females. Living with a parent (OR 1.57; P=0.01), seeking employment (OR 1.66; P=0.005) and cannabis consumption (several times per month and several times per week, OR 1.94 and 3.66, respectively, P<0.05) were associated with binge drinking. Conclusions Our survey showed that it is possible to identify individuals and groups at higher risk of binge drinking. This identification would allow for a focus on specific targets and would facilitate the redesign of prevention programmes. The increased use of psychoactive substances among youths should be studied extensively to promote successful prevention campaigns.
Business Case Analysis and the Confounds of Innovation Driven by Performance-Based Postproduction Support Strategies
Authors: Randall Wesley S. , Brady Stephan P. , Nowicki David R. 
Published: February 2012

AbstractThe postproduction support cost of complex systems such as rail, power, and defense often exceed the cost of research, design and production. As such systems age and degrade the traditional maintenance, repair, and overhaul (MRO) approach does little to reduce their cost or improve performance. The failure of traditional MRO has given rise to a number of multi-year, performance-based, postproduction support strategies. These strategies drive investment to reduce cost, infuse innovation, and increase system performance. The dynamism and innovation associated with these strategies makes it difficult to conduct a business case analysis (BCA) that compares the return on sales model of traditional MRO to the return on investment model of performance based strategies. To address this gap in practice and theory we provide a framework for rationalizing performance-based and traditional strategies within the same BCA. We develop questions to guide the creation of BCAs that include performance- based options. Finally, we offer analytical guidance to support direct economic comparison between these two fundamentally different postproduction support strategies.
Physical activity, obesity, and cognitive impairment among women with systemic lupus erythematosus
Authors: Katz Patricia , Julian Laura , Tonner Mary C. , Yazdany Jinoos , Trupin Laura , Yelin Edward , Criswell Lindsey A. 
Published: February 2012

AbstractObjectiveTo examine relationships of obesity and physical inactivity to cognitive impairment in women with systemic lupus erythematosus (SLE).MethodsBody composition was measured with dual x‐ray absorptiometry (DXA) for 138 women with SLE. Obesity was defined by total percent body fat. Physical activity was ascertained with the self‐reported International Physical Activity Questionnaire; inactivity was defined as expenditure of <600 metabolic equivalent minutes/week. Cognitive function was assessed with a 12‐index neuropsychological battery. Impairment was defined as age‐adjusted Z scores ≤1.5 SDs below the mean on 1 of 3 of tests completed. Scores were obtained for the total battery and for memory and executive function components. Multivariate analyses examined the relationship of obesity and physical activity, individually and combined, to cognitive impairment, controlling for education, race/ethnicity, disease activity, glucocorticoid use, and depression.ResultsFifteen percent of subjects were cognitively impaired, 28% were physically inactive, and 50% were obese. Five percent of active women were impaired on the executive function battery compared to 23% of those who were inactive (P = 0.003). Obese women were more likely to be impaired on the total battery (6% versus 23%; P = 0.007) and on the executive function portion (2% versus 19%) than nonobese women. In multivariate analysis, both inactivity and DXA‐defined obesity were significantly associated with impairment in executive function (inactivity: odds ratio [OR] 9.4, 95% confidence interval [95% CI] 1.7–52.8; obesity: OR 14.8, 95% CI 1.4–151.0).ConclusionBoth obesity and inactivity were significantly and independently associated with impairment in cognitive function. If longitudinal studies show that physical inactivity and obesity are precursors to cognitive impairment, these may become important targets for intervention.
Densification Behavior and Wear Response of Spark Plasma Sintered Iron‐Based Bulk Amorphous Alloys
Authors: Singh Ashish , Paital Sameer R. , Andapally Abhinay , Dahotre Narendra B. , Harimkar Sandip P. 
Published: February 2012

AbstractIn the present study, spark plasma sintering (SPS) process is used to sinter Fe‐based bulk amorphous alloys from starting amorphous powder. The sintering was performed in supercooled liquid region (at 630 °C with uniaxial pressure of 70 MPa) where plastic flow of the amorphous powder results in better densification without crystallization. To study the crystallization behavior and its influence on mechanical behavior, the sintered discs were de‐vitrified by annealing at 700 and 800 °C. Detailed characterization of phase development, microhardness at different loads, and wear behavior of the as‐sintered and annealed alloys is presented.
Self‐Assembled Complexes of Horseradish Peroxidase with Magnetic Nanoparticles Showing Enhanced Peroxidase Activity
Authors: Corgié Stéphane C. , Kahawong Patarawan , Duan Xiaonan , Bowser Daniel , Edward Joseph B. , Walker Larry P. , Giannelis Emmanuel P. 
Published: February 2012

AbstractBio‐nanocatalysts (BNCs) consisting of horseradish peroxidase (HRP) self‐assembled with magnetic nanoparticles (MNPs) enhance enzymatic activity due to the faster turnover and lower inhibition of the enzyme. The size and magnetization of the MNPs affect the formation of the BNCs, and ultimately control the activity of the bound enzymes. Smaller MNPs form small clusters with a low affinity for the HRP. While the turnover for the bound fraction is drastically increased, there is no difference in the H2O2inhibitory concentration. Larger MNPs with a higher magnetization aggregate in larger clusters and have a higher affinity for the enzyme and a lower substrate inhibition. All of the BNCs are more active than the free enzyme or the MNPs (BNCs > HRP ≫ MNPs). Since the BNCs show surprising resilience in various reaction conditions, they may pave the way towards new hybrid biocatalysts with increased activities and unique catalytic properties for magnetosensitive enzymatic reactions.
The Performance of Small‐Pore Microporous Aluminophosphates in Low‐Temperature Solar Energy Storage: The Structure–Property Relationship
Authors: Ristić Alenka , Logar Nataša Zabukovec , Henninger Stefan K. , Kaučič Venčeslav 
Published: February 2012

AbstractThe utilization of the reversible chemical and physical sorption of water on solids provides a new thermal energy storage concept with a great potential for lossless long‐term storage. The performance of microporous aluminophosphates in heat storage applications is highlighted by a comparative thermogravimetric and calorimetric study of three known materials (SAPO‐34, AlPO4‐18, APO‐Tric) and is correlated with their structural features. The maximum water sorption capacity is similar for all three samples and results in a stored energy density of 240 kWh m−3 in the 40–140 °C range. The elemental composition influences the gradual (silicoaluminophosphate SAPO‐34) or sudden (aluminophosphates AlPO4‐18, APO‐Tric) water uptake, with the latter being favourable in storage systems. The driving force for the determined sorption process is the formation of highly ordered water clusters in the pores, which is enabled by rapid and reversible changes in the Al coordination and optimal pore diameters. The ease with which changes in the Al coordination can occur in APO‐Tric is related to the use of the fluoride route in the synthesis. The understanding of these fundamental structure/sorption relationships forms an excellent basis for predicting the storage potential of numerous known or new microporous aluminophosphates and other porous materials from their crystal structures.
Hyposplenism: Comparison of different methods for determining splenic function
Authors: Lammers A.J. Jolanda , de Porto Alexander P.N.A. , Bennink Roelof J. , van Leeuwen Ester M.M. , Biemond Bart J. , Goslings J. Carel , van Marle Jan , ten Berge Ineke J.M. , Speelman Peter , Hoekstra Joost B.L. 
Published: February 2012

AbstractAsplenic patients are at risk for pneumococcal sepsis. Patients with hyposplenic function, such as associated with sickle cell disease (SCD), are also at risk. However, tests to assess splenic function are either unavailable or lacking standardization. The aim of this study was to compare different methods for determining splenic function. Eighteen patients with SCD (i.e., 10 heterozygous (SC) and 8 homozygous (SS) SCD patients), and eight splenectomized patients were compared to 10 controls. All subjects underwent spleen scintigraphy, after which functional splenic volumes (FSV) were calculated. FSV was compared to immunological function and B cell‐subsets, as well as phagocytic function represented by the presence of Howell Jolly bodies (HJB) and percentages of pitted red cells (PIT). Heterozygous SCD (SC) patients had increased splenic volumes, but diminished FSV, homozygous SCD (SS) patients were asplenic. Splenectomized and SS patients had a strongly reduced phagocytic and immunological function. SC patients had reduced anti‐polysaccharide responses without an increase in PIT. FSV correlated significantly with phagocytic and immunological function. HJB were indicative of splenic dysfunction, HJB absence was not indicative of normal functioning splenic tissue. Although visualizing HJB is methodologically advantageous to PIT, both are valid biomarkers of splenic dysfunction. The amount of non‐switched memory B cells is strongly correlated to FSV. Am. J. Hematol. 87:484–489, 2012. © 2012 Wiley Periodicals, Inc.
Mutations inNRXN1in a family multiply affected with brain disorders:NRXN1mutations and brain disorders
Authors: Duong Linh , Klitten Laura L. , Møller Rikke S. , Ingason Andrés , Jakobsen Klaus D. , Skjødt Celina , Didriksen Michael , Hjalgrim Helle , Werge Thomas , Tommerup Niels 
Published: February 2012

AbstractMutation of the neurexin1‐gene,NRXN1, interrupting the expression of neurexin1 has been associated with schizophrenia, autism, and intellectual disability. We have identified a family multiply affected with psychiatric, neurological, and somatic disorders along with an intricate co‐segregation ofNRXN1mutations. The proband suffered from autism, mental retardation, and epilepsy and on genotyping it was revealed that he carried a compound heterozygous mutation in theNRXN1consisting of a 451 kb deletion, affecting the promoter and first introns in addition to a point mutation, predicted to be deleterious toNRXN1. The deletion was passed on from the patient's mother who was clinically characterized by sub‐diagnostic autistic traits in addition to type 1 diabetes mellitus. The point mutation was subsequently found in the patient's brother, suffering from a psychotic disorder, which implies that the point mutation was inherited from the deceased father, who was diagnosed with schizophrenia. The observations suggest a possible gene‐dose effect ofNRXN1mutations on type and severity of mental illness and support the notion that the penetrance and pleiotropy of pathogenic CNVs in general are determined by additional genetic variants in the genome. Finally the findings also propose a linkage ofNRXN1neurobiology to epilepsy and possibly to type 1 diabetes. © 2012 Wiley Periodicals, Inc.
Patterns of dural involvement in sinonasal tumors: prospective correlation of magnetic resonance imaging and histopathologic findings
Authors: McIntyre John B. , Perez Carlos , Penta Mrudula , Tong Liyue , Truelson John , Batra Pete S. 
Published: February 2012

AbstractBackground:The presence of dural invasion serves as an important negative predictive factor for survival in sinonasal and skull‐base neoplasms. The objective of this study was to prospectively correlate preoperative magnetic resonance imaging (MRI) findings with intraoperative surgical findings and histopathology to establish key correlates for dural involvement in sinonasal tumors.Methods:Prospective blinded MRI review of 50 sinonasal and anterior skull‐base neoplasms was performed by a staff neuroradiologist. Retrospective chart review was performed to accrue salient patient and tumor data.Results:The mean patient age was 54.6 years with a male:female ratio of 1.8:1. The most common tumor histology included adenocarcinoma (18%), squamous cell carcinoma (18%), mucosal melanoma (8%), and olfactory neuroblastoma (8%). MRI demonstrated dural enhancement in 20 patients (40%), with 1 mm and ≥2 mm thickening being noted in 14 (70%) and 6 (30%) cases, respectively. Spectrum of MR findings in these 20 patients included linear enhancement in 15 (75%), nodular thickening in 5 (25%), and loss of hypointense zone in 13 (65%) cases. Intraoperative findings and histology confirmed dural invasion in 12 of 20 cases (60%). Positive predictive value (PPV) of linear and nodular dural enhancement for dural invasion was 46.7% and 100%, respectively. One millimeter (1 mm) and ≥2 mm of dural thickening demonstrated PPV of 42.9% and 100%, respectively. Loss of the hypointense zone had PPV of 92.3% for dural invasion. Fisher's exact test demonstrated that loss of hypointense zone and dural thickening ≥2 mm were statistically associated with dural involvement (p < 0.05).Conclusion:The presence of ≥2 mm of dural thickening, loss of hypointense zone, and nodular dural enhancement were highly predictive for presence of dural invasion by sinonasal malignant tumors. Preoperative knowledge of these MRI patterns may better guide surgical planning and patient counseling. © 2012 ARS‐AAOA, LLC.
Bioflavonoid profile of citrus juices from Greece
Authors: Anagnostopoulou Maria A. , Kefalas Panagiotis 
Published: February 2012

ABSTRACTHigh‐performance liquid chromatography with confirmation by UV–visible photodiode array detector–positive electrospray ionization–mass spectrometry [HPLC‐UV–vis‐DAD‐(+ESI)‐MS] with enhanced fragmentation by appropriate adjustment of the cone voltage was used to determine bioflavonoid content of five citrus species (tangerine, sanguine, sour orange, lemon and grapefruit) cultivated in Greece which come from citrus varieties analyzed for the first time. The main groups of bioflavonoids found in the juice of the citrus species according to HPLC retention times, spectral data and literature references were O‐glycosylated flavanones and flavones, C‐glucosylated flavones, O‐glucosylated flavones, O‐C‐glucosylated flavones like saponarin and a phenolic derivative. Copyright © 2012 John Wiley & Sons, Ltd.
Practical determination of methotrexate in serum of rheumatic patients by LC‐MS/MS
Authors: Sonemoto Emi , Kono Narumi , Ikeda Rie , Wada Mitsuhiro , Ueki Yukitaka , Nakashima Kenichiro 
Published: February 2012

ABSTRACTA rapid and simple liquid chromatography tandem mass spectrometry method for determination of methotrexate (MTX) in rheumatic patients' serum is described. Serum spiked with pterin as an internal standard was deproteinized with methanol. The separation of MTX from interfering peaks in matrix was achieved on a Luna 3 µm C18 (100 × 4.6 mm i.d.) column with a mixture of 1% acetic acid and acetonitrile (88:12, v/v) within 5 min. Multiple reaction monitoring transitions monitored for MTX were m/z 455.2–308.1. The calibration curve of MTX in serum showed a good linearity (r = 0.999). Limits of detection and quantification of MTX at a signal‐to‐noise ratio of 3 and 10 were 3.0 n m (4.4 fmol/injection) and 10.0 n m (14.5 fmol/injection), respectively. The accuracy and precision for intra‐ and inter‐day assays were 94.6–106.5% and <5.5 and <5.1%, respectively. Furthermore, the proposed method was successfully applied to the sera nine rheumatic patients receiving MTX treatment. Copyright © 2012 John Wiley & Sons, Ltd.
Identification of modification sites on human serum albumin and human hemoglobin adducts with houttuynin using liquid chromatography coupled with mass spectrometry
Authors: Deng Zhipeng , Zhong Dafang , Chen Xiaoyan 
Published: February 2012

ABSTRACTHouttuynin, a β‐keto aldehyde compound, is the major active ingredient in herba houttuyniae injection. The injection was once used as an anti‐inflammatory drug associated with occasional serious hypersensitivity reactions in the clinic, which were proposed to be related to the formation of protein adducts. Nα‐Boc‐lysine, FEEM and IVTNTT were used as model amino acids or peptides containing one nucleophilic residue to investigate adduct types by liquid chromatography coupled with ion trap mass spectrometry (LC/MSn) and high‐resolution quadrupole time‐of‐flight mass spectrometry (Q‐TOF MS). These adducts were respectively characterized as Schiff bases formed by 1:1 reaction of houttuynin with lysine or N‐terminal residue and pyridinium adducts by 2:1 reaction. LC/MSn analysis of trypsin digests of HSA/Hb incubations with houttuynin revealed that houttuynin‐modified HSA adducts were formed mainly at N‐terminal amino acid and lysine residues, specifically at Lys‐212, Lys‐414 and Lys‐525 for Schiff base adducts, and at Lys‐414 and Lys‐432 for pyridinium adducts, and houttuynin adducted more readily with N‐terminal valine of the α‐ and β‐chains in Hb and lysine amine (Lys‐62) of the β‐chain for Schiff base adducts. The results showed the direct modification of houttuynin to HSA/Hb in vitro, which was speculated to be responsible for the adverse reactions induced by houttuyniae injection. Copyright © 2012 John Wiley & Sons, Ltd.
Simple batch distillation of a binary mixture
Authors: Binous Housam , Al‐Harthi Mamdouh A. 
Published: February 2012

ABSTRACTA simple experiment such as the batch distillation of an ethanol–water binary mixture can be performed in a 3‐h laboratory session using a very rudimentary apparatus consisting of a still pot and two thermocouples. Yet, the results can lead to very interesting insights to distillation and chemical engineering thermodynamics. The present article describes how one can exploit this simple laboratory experiment to teach these various aspects of chemical engineering. In addition, several simple calculations using computer software such as Mathematica® are performed to explain, interpret and reproduce theoretically all the gathered experimental data during the laboratory session.© 2012 Wiley Periodicals, Inc. Comput Appl Eng Educ 22:649–657, 2014; View this article online at wileyonlinelibrary.com/journal/cae; DOI 10.1002/cae.21556
Enzyme‐Regulated Activation of DNAzyme: A Novel Strategy for a Label‐Free Colorimetric DNA Ligase Assay and Ligase‐Based Biosensing
Authors: He Kaiyu , Li Wang , Nie Zhou , Huang Yan , Liu Zhuoliang , Nie Lihua , Yao Shouzhuo 
Published: February 2012

AbstractThe DNA nick repair catalyzed by DNA ligase is significant for fundamental life processes, such as the replication, repair, and recombination of nucleic acids. Here, we have employed ligase to regulate DNAzyme activity and developed a homogeneous, colorimetric, label‐free and DNAzyme‐based strategy to detect DNA ligase activity. This novel strategy relies on the ligation‐trigged activation or production of horseradish peroxidase mimicking DNAzyme that catalyzes the generation of a color change signal; this results in a colorimetric assay of DNA ligase activity. Using T4 DNA ligase as a model, we have proposed two approaches to demonstrate the validity of the DNAzyme strategy. The first approach utilizes an allosteric hairpin‐DNAzyme probe specifically responsive to DNA ligation; this approach has a wide detection range from 0.2 to 40 U mL−1 and a detection limit of 0.2 U mL−1. Furthermore, the approach was adapted to probe nucleic acid phosphorylation and single nucleotide mismatch. The second approach employs a “split DNA machine” to produce numerous DNAzymes after being reassembled by DNA ligase; this greatly enhances the detection sensitivity by a signal amplification cascade to achieve a detection limit of 0.01 U mL−1.