bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Complex Intracellular Lifecycle of Staphylococcus aureus Contributes to Reduced Antibiotic Efficacy and Persistent Bacteremia
Authors: Volk Cecilia F. , Proctor Richard A. , Rose Warren E. 
Published: June 2024

Staphylococcus aureus bacteremia continues to be associated with significant morbidity and mortality, despite improvements in diagnostics and management. Persistent infections pose a major challenge to clinicians and have been consistently shown to increase the risk of mortality and other infectious complications. S. aureus, while typically not considered an intracellular pathogen, has been proven to utilize an intracellular niche, through several phenotypes including small colony variants, as a means for survival that has been linked to chronic, persistent, and recurrent infections. This intracellular persistence allows for protection from the host immune system and leads to reduced antibiotic efficacy through a variety of mechanisms. These include antimicrobial resistance, tolerance, and/or persistence in S. aureus that contribute to persistent bacteremia. This review will discuss the challenges associated with treating these complicated infections and the various methods that S. aureus uses to persist within the intracellular space.
In Vivo Expression of Chicken Gut Anaerobes Identifies Carbohydrate- or Amino Acid-Utilising, Motile or Type VI Secretion System-Expressing Bacteria
Authors: Rajova Jana , Zeman Michal , Seidlerova Zuzana , Vlasatikova Lenka , Matiasovicova Jitka , Sebkova Alena , Faldynova Marcela , Prikrylova Hana , Karasova Daniela , Crhanova Magdalena , Kulich Pavel , Babak Vladimir , Volf Jiri , Rychlik Ivan 
Published: June 2024

Complex gut microbiota increases chickens’ resistance to enteric pathogens. However, the principles of this phenomenon are not understood in detail. One of the possibilities for how to decipher the role of gut microbiota in chickens’ resistance to enteric pathogens is to systematically characterise the gene expression of individual gut microbiota members colonising the chicken caecum. To reach this aim, newly hatched chicks were inoculated with bacterial species whose whole genomic sequence was known. Total protein purified from the chicken caecum was analysed by mass spectrometry, and the obtained spectra were searched against strain-specific protein databases generated from known genomic sequences. Campylobacter jejuni, Phascolarctobacterium sp. and Sutterella massiliensis did not utilise carbohydrates when colonising the chicken caecum. On the other hand, Bacteroides, Mediterranea, Marseilla, Megamonas, Megasphaera, Bifidobacterium, Blautia, Escherichia coli and Succinatimonas fermented carbohydrates. C. jejuni was the only motile bacterium, and Bacteroides mediterraneensis expressed the type VI secretion system. Classification of in vivo expression is key for understanding the role of individual species in complex microbial populations colonising the intestinal tract. Knowledge of the expression of motility, the type VI secretion system, and preference for carbohydrate or amino acid fermentation is important for the selection of bacteria for defined competitive exclusion products.
SINGING COURSES FOR UKRAINIAN FAMILIES AS A TEHNOLOGY TO REVIVE THE TRADITIONS OF UKRAINIAN SINGING NOWADAYS
Authors: Lotsman R. 
Published: June 2024

The article highlights the author’s practical experience in organizing and conducting singing courses for Ukrainian families in various educational institutions – preschool, after-school, and school, as well as, in cultural institutions, and centers of the Ukrainian community in other countries. Different forms of Ukrainian singing classes using the “song diary” video blog, the innovative “song basket” technology, online schools for mothers, etc. have been considered. The author investigates the issue of preserving and reviving the traditions of Ukrainian singing in everyday life and analyzes their role in the formation of spiritual and aesthetic values of the younger generation. The singing courses, which have been running for five years and for an audience of all ages, are aimed at the musical and comprehensive development of Ukrainian adults and children.
Singing courses for Ukrainian families are a technology for reviving the traditions of Ukrainian singing in modern conditions. They are essential for national identification of the nation, and patriotic upbringing of the younger generation. The art-therapeutic effect of Ukrainian singing consists in harmonizing the atmosphere and relations in a family or social circle; in particular, it contributes to the moral recovery of military personnel and their relatives.
During the research, various methods have been used. They are the following: theoretical (analysis, systematization, and generalization of scientific and pedagogical experience, situation modeling, etc.); empirical (questionnaires, surveys, conversation, pedagogical observation, organization of events, identification of pedagogical conditions and verification in practice of various forms of work on the formation of the culture of Ukrainian singing in course participants, methodical support and online training).
Singing courses made it possible to reveal the multi-vector nature of implemented artistic and educational projects, such as “Song Diary,” “Secrets of Ukrainian Singing,” “Ukrainian Singing Online,” “Ukrainian Singing for Mothers,” “Song Party,” “Let’s Win with a Song!,” “Song Svetlytsia,” “Song Basket,” “Universe of Ukrainian Singing,” “Pysulky vid Mamulka” etc. In the future, a presentation of a mobile application for studying the first fifty Ukrainian songs and a website with content (audio lessons, manuals, a repertoire list, and useful links) will be prepared.
« Once more unto the breach, dear friends, once more » : réponse à Antoine Lourdeau
Authors: Gómez coutouly Yan axel 
Published: June 2024

Suite à la publication d’un travail de synthèse questionnant le caractère anthropique de certaines industries du Pléistocène dans les Amériques (Gómez Coutouly, 2021), notamment au Brésil (sites de Pedra Furada, Vale da Pedra Furada, Sítio do Meio, etc.), Antoine Lourdeau (ce volume) fournit une réponse détaillée apportant des informations complémentaires et remettant en cause certaines des données présentées au sein de mon article. Sa contribution me permet dans ce nouveau texte de préciser plusieurs points tout en soulevant de nouvelles interrogations. In fine, si ses
discussions sont les bienvenues, elles ne suffisent pas, à mon sens, pour trancher sur le caractère anthropique de ces industries.
Teacher Accompaniment in Improving Digital Literacy Through Metamorphosis Props Training QR-Code
Authors: Widiyati Evita , Kibtiyah Asriana , Bahrodin Ariga 
Published: June 2024

The purpose of this activity is to provide insight and increase teacher knowledge at MI Al-Ittihad about making Algameta media, how to make QR-Code online, and the implementation of teaching aids with digital literacy. The service team uses the Participatory Action Research method in providing participatory training which makes educators as objects to be able to use digital media in the form of QR-Code. The service team participatively provides training at MI Al-Ittihad and involves educators to encourage changes in the teaching and learning process towards a creative, innovative and fun direction. Based on the results of the pretest and posttest that have been carried out, it can be seen that the service is running successfully. The results achieved from this activity are in the form of increased teacher creativity in innovating learning on teaching aids implemented with digital media, increasing teacher ability to make Algameta assisted by QR-Code digital media and increasing teacher digital literacy. This is evidenced by the Paired Sample Test which is known that the Sig. (2-tailed) of 0.021 <0.05, it can be concluded that by holding this training can improve the competence of the training participants.
ANALlSlS PENGARUH PEMBlAYAAN MUDHARABAH DAN MUSYARAKAH TERHADAP LABA BERSlH BANK BCA SYARlAH TAHUN 2015 – 2023
Authors: Khasanah Umi Nur , Fauzi Achmad Noor 
Published: June 2024

Penelitian ini merupakan penelitian yang digunakan untuk mengetahui dan menganalisis pengaruh pembiayaan mudharabah dan pembiayaan musyarakah secara simultan dan parsial terhadap laba bersih BCA Syariah periode juni 2015 – juni 2023.Metode deskriptif kuantitatif digunakan di penelitian ini dengan data sekunder yang berasal dari laporan keuangan triwulan tahun periode tersebut berbentuk data pembiayaan mudahrabah, pembiayaan musyarakah, dan laba bersih setelah pajak pada tahun berjalan pada periode juni 2015 – juni 2023.Penelitian ini menggunakan alat analisis yaitu reggresi linier berganda.Teknik statistik untuk olah data menggunakan Applikasi SPSS 23.0 untuk menguji data dalam penelitian ini dengan uji asumsi klasik.Hasil penelitian yang dilakukan menunjukkan bahwa : 1. Pembiayaan mudharabah tidak berpengaruh terhadap laba bersih. 2. Pembiayaan mudharabah tidak berpengaruh terhadap laba bersih 3. Pembiayaan mudharabah dan pembiayaan musyarakah secara bersaamaan maupun secara simultan dapat berpengaruh pada laba bersih Bank BCA Syariah periode juni 2015 – juni 2023.
Kata Kunci : Mudharabah, Musyarakah, Iaba Bersih
العنــف ضــد كبار الســن وطــرق مواجهتـــــه
Authors: سليمان ابوبكر محمد د.اشرف 
Published: June 2024

يهدف هذا البحث إلى التعرف على أشكال العنف ضد كبار السن(جسدي،نفسي،إهمال)، كما يهدف أيضا إلى التعرف على أسباب وأثار العنف ضد المسنين، وكيفيه مواجهه هذه الظاهرة. وقد توصلت الدراسة إلى مجموعة من النتائج أهمها: أن مظاهر العنف ضد المسنين تمثلت في العنف الجسدي والنفسي والإهمال، وقد توصلت الدراسة أيضا إلى أن أهم أسباب العنف الأسري ضد كبار السن المستوى الاقتصادي و التعليمي للمسن والحالة الاجتماعية، وأيضا ظاهرة التحضر والتغير السريع، وأيضا توصلت الدراسة إلى أهم الآثار المترتبة على العنف الأسري وهي فقدان الأدوار الاجتماعية ،ومشكلة وقت الفراغ، والصراع بين الأجيال.
دراسة بعض العوامل المؤثرة على المهارات الاجتماعية لدى التلاميذ المعاقين ذهنياً القابلين للتعلم (دراسة حالة بمدرسة الإشراقة بدار الرعاية بمدينة البيضاء عام 2022)
Authors: السيد إبراهيم الهيتى د. على 
Published: June 2024

يعد الإهتمام بالتلاميذ بشكل عام والمعاقين بشكل خاص اهتماماً بالمجتمع بآسره، ويقاس تقدم المجتمعات ورقيها بمدى اهتمامها وعنايتها بهم، والعمل على تنمية مهاراتهم المختلفة. ويعانى التلميذ المعاق ذهنياً من قصور فى المهارات الاجتماعية، والتى تظهر فى ضعف الاعتماد على النفس، والمعاناة من السلوك الإنسحابى ، وعدم القدرة على إقامة علاقات اجتماعية . وتوصل البحث إلى وجود فروق ذات دلالة إحصائية عند مستوى (0.05 ≤ α ) بين النوع والعمر ومستوي الذكاء ومستوى تعليم الأب والأم والدخل الشهري للأسرة وعدد أفرادها و كل من المهارات الاجتماعية المتعلقة بتبادل العلاقات الشخصية مع الآخرين وأداء والوظائف الاستقلالية المتعلقة بالطعام و اللباس والوظائف الاستقلالية المتعلقة بالسلامة العامة والنظافة. كما اتضح أن أكثر العوامل تأثيراً علي المهارات الاجتماعية المتعلقة بتبادل العلاقات الشخصية مع الآخرين وأداء الأعمال كانت النوع ومستوى التعليم للأب .وتبين أن أكثر العوامل تأثيراً علي الوظائف الاستقلالية المتعلقة بالطعام و اللباس كانت العمر ، والدخل الشهري للأسرة .واتضح أن أكثر العوامل تأثيراً علي الوظائف الاستقلالية المتعلقة بالسلامة العامة والنظافة كانت العمر ، والدخل الشهري للأسرة وعدد أفراد الأسر ة للتلميذ المعاق ذهنياً والقابل للتعلم
أساليب التحليل الكارتوغرافي لعنصر المطر في منطقة حوض وادي اللولب بإقليم الجبل الأخضر باستخدام معامل ثايسن THIESSEN
Authors: رمضان علي سعد أ. عادل 
Published: June 2024

تعرض هذه دراسة أحد اساليب التحليل الكارتوغرافي لعنصر مناخي مهم وهو عنصر المطر في منطقة حوض وادي اللولب بإقليم الجبل الأخضر بالاعتماد على (3) متغيرات (محطات رصد -بطة – البياضة -تاكنس).
تم تحليل ودراسة صورة النظام المطري خلال فترات زمنية مختلفة بين المحطات المناخية الثلاث في حوض وادي الولب حيث تم حساب المعدل السنوي للأمطار باستخدام طريقة مضلعات ثايسن Thiessen، حيث أظهر التحليل الكارتوغرافي فاعلية هذا الأسلوب الذي أعطى الصورة الفعلية لكمية الامطار في تلك المحطات، خلافاً للأسلوب المتبع وهو المتوسط الحسابي الذي يركز على متوسط كمية الامطار الساقطة على محطة القياس وأجهزة الرصد، كما اظهر هذا التحليل النطاقات المطرية الحقيقية الموزعة على المساحة المخصصة لكل محطة منفردة من خلال التقسيم المساحة والسيطرة المطرية لكل محطة، حيث تتغير النطاقات المطرية تبعاً لتغير المساحة، مع ملاحظة أن طريقة ثايسن يمكن تطبيقها على عدد كبير من المحطات المناخية.

يستلزم هذ الأسلوب الاحصائي الكارتوغرافي التجهيز الجيد لبيانات الامطار وتحديد ووضع الاحداثيات لكل محطة مناخية، والربط بين قواعد البيانات المناخية والكارتوغرافية.
Calidad del Servicio en Destinos Turísticos: Caso de Servicios de Alojamiento en Tlatlauquitepec, Puebla
Authors: Sánchez García Adán , Hernández Méndez Claudia , Chávez Galavíz Álvaro 
Published: June 2024

La investigación presentada consistió en valorar la calidad en el servicio de alojamiento, basado en satisfacción de las necesidades y expectativas de los propios clientes. A partir de la investigación documental se define la calidad en servicio, el concepto de alojamiento y la situación del turismo y la hotelería en Tlatauquitepec, Puebla, con el fin de conocer el devenir y las características del sector hotelero local. La metodología para valorar la calidad de servicio percibida por los clientes se respaldó en la obtención de información, a través de trabajo de campo, para lograr consolidar indicadores sobre confianza, fiabilidad, responsabilidad, capacidad de respuesta y tangibilidad en el marco del modelo SERVQUAL. La finalidad del proyecto es generar información para quien toma decisiones en el ramo hotelero local, con el propósito de concientizar sobre las áreas de oportunidad que tienen los servicios de alojamiento.
Rationing of medical care: how medical care to be distributed in conditions of limited resources
Authors: Vlassov Vasily V. , Shishkin Sergey V. , Chirikova Alla E. , Khazan Petr L. , Vlasova Anna V. 
Published: June 2024

Background. Rationing of health care—restricting patients’ access to potentially beneficial health care interventions through non-market instruments—is a natural feature of all health care systems as they operate under resource constraints. The purpose of this study is to characterize rationing practices and the attitude of doctors themselves to it, with an emphasis on comparing Russia and the United States and on changes in the perception of rationing during the COVID-19 pandemic.
Methods. We conducted a bibliometric analysis of publications in the medical scientific literature since 1989 on the issue of rationing of medical care. To characterize rationing practices in Russia and the United States and the attitudes of doctors towards them, we used data from published studies and data from semi-structured in-depth interviews with 28 Russian doctors.
Results. Despite the increasing frequency of publications related to the topic of resource allocation over the past 20 years, studies using the term “rationing” are rare. Both Russia and the USA have practices of explicit and implicit rationing. In Russia they are more diverse and widespread. In both countries, doctors prefer implicit rationing and do not want open discussion of these issues. The practice of rationing is institutionalized. In Russian medical organizations its most common form is a chain of permissions for the use of resources. But most doctors believe they are not rationing care. The pandemic briefly brought the topic of rationing into the public sphere, but then its discussion was limited. The probable reason is that medical practice during the pandemic was carried out within the previous legal framework. Professional organizations have developed several recommendations for rationing, but their usefulness and level of acceptance by professionals and the public is unclear.
Conclusions The transition from implicit to explicit rationing is extremely difficult, but is necessary to ensure equitable patient access to scarce medical resources and the effective functioning of health care systems. A major barrier to the explicit and informed use of rationing instrument is the limited public acceptance of it and the reluctance of professional communities to make public decisions that maximize public benefit by prioritizing access to effective interventions.
Outils d’identification de signes de souffrance psychique dans la clinique avec des bébés dans nos programmes associés
Authors: Lunardelli-Jacintho Ana , Kupfer Cristina 
Published: June 2024

Ce travail a cherché à vérifier la valeur d’accompagnement des outils d’identification de signes de souffrance précoce suivants : le protocole irdi , le questionnaire PRÉAUT et les ssp . Il fait valoir que leur utilisation complémentaire, dans le cadre d’interventions auprès de bébés, permet de soutenir une lecture clinique des problématiques subjectives de chaque enfant dans son lien avec les adultes et de montrer leur évolution tout au long des séances. Il aborde également certaines spécificités des outils à la lumière de leurs références théoriques. Enfin, il commente la question de l’utilisation de signes cliniques dans la promotion des soins à la petite enfance et considère que leur attribuer un statut de parole correspond à l’engagement éthique d’écouter le corps du bébé et de lui donner une voix.
La pré-appropriation capacitante d’un outil de contrôle de la qualité : le cas d’une accréditation à l’université
Authors: Hertzog Marion , Bollecker Marc 
Published: June 2024

De nombreux travaux en sciences de gestion sont consacrés à l’appropriation des outils de gestion dans les organisations publiques. En revanche, rares sont ceux qui traitent d’une de ses phases, la pré-appropriation, et ceux qui portent sur l’appropriation des outils de contrôle de la qualité. Dans le contexte des universités françaises, les études consacrées à ces deux points sont peu nombreuses. Or, des constats de rejet de certains outils dans ces organisations méritent que l’on s’intéresse aux modalités de leur déploiement et, en particulier, à la pré-appropriation que nous caractérisons comme les premières représentations qu’ont les acteurs d’un outil. Certains auteurs soulignent l’importance d’engager un pilotage actif de ces dernières en associant les acteurs afin qu’ils puissent mieux maîtriser leur utilisation future. L’ancrage théorique retenu dans cet article est celui du contrôle capacitant. Dès lors, cet article se structure autour de la problématique suivante : la pré-appropriation d’un outil de contrôle est-elle capacitante ? Pour répondre à la problématique, nous avons mené une étude exploratoire sur une composante d’une université française ayant le projet de déployer une accréditation internationale. 18 interviews ont été menées à partir d’un guide d’entretien. Ils ont été complétés par une analyse documentaire pour cerner les spécificités de la composante universitaire et de la certification. Les résultats montrent une pré-appropriation différenciée tant sur les impacts de cette dernière que sur ses modalités de fonctionnement et les marges de manœuvre qu’elles procurent aux acteurs. Ils permettent de tirer des enseignements provisoires sur la mise en œuvre des caractéristiques du contrôle capacitant dans la phase de pré-appropriation.
L’humour pour apaiser la discorde
Authors: Rioux François 
Published: June 2024

Dans le dynamique monde des affaires, où les interactions professionnelles sont souvent empreintes de stress et de pression, les conflits peuvent surgir à tout moment. Pour prévenir et désamorcer les tensions, une arme souvent sous-estimée et pourtant puissante existe : l’humour. Comment faire de cette forme d’esprit un véritable outil stratégique ?
De sérieux freins à la carrière des femmes
Authors: Ethier Claudia , Gosselin Alain 
Published: June 2024

Malgré les progrès accomplis ces dernières années, beaucoup de chemin reste à parcourir pour que les femmes puissent briser le fameux plafond de verre qui se dresse au-dessus de leur tête. Aujourd’hui encore, elles occupent seulement 35 % des postes de direction, gagnent 17 % de moins que les hommes, et leur proportion au sein des CA plafonne à 21 % 1 . Comment les principales intéressées perçoivent-elles leur progression de carrière et comment affrontent-elles tous les obstacles qui entravent leur ascension ?
Créer un climat relationnel sécurisant au travail, de Marion Malaussena-Drosson
Authors: Jézéquel Myriam 
Published: June 2024

Les situations qui peuvent nuire à la performance des travailleurs et à leur santé sont nombreuses : conflits entre collègues, tensions et plaintes explicites, manque de reconnaissance ou de cohésion… Comment créer alors un climat relationnel sécurisant, propice à apaiser les tempêtes autant qu’à stimuler les esprits ? Outils et conseils de la facilitatrice relationnelle française Marion Malaussena-Drosson.
La transparence dans l’espace numérique, de Vincent Mabillard et Jean-Patrick Villeneuve
Authors: Jézéquel Myriam 
Published: June 2024

La prolifération des contenus en ligne s’ajoute à l’obligation légale de transparence et modifie en profondeur les pratiques de bonne gouvernance et la gestion des organisations publiques. Faut-il toujours plus de transparence ou doit-on tout simplement mieux l’encadrer ? Voici quelques clés pour alimenter notre réflexion.
The relation between CircRNA0056618 and type 2 diabetes mellitus and insulin resistance through miRNA-206/PTPn-1 pathway
Authors: Abdelgwad Marwa M. , Rashed Maysa H. , Helmy Mona Y. , Eldemery Ahmed B. , Fattah Dina S.A. 
Published: June 2024

Background
Diabetes mellitus (DM) is a well-known metabolic syndrome characterized by hyperglycemia produced by a defect in insulin synthesis, insulin action, or a combination of the two.

Objective
The aim of this work was to find out how circular RNA 0056618 (circRNA 0056618) interacts with miRNA-206 to control blood sugar levels in type-2 diabetes mellitus (T2DM), as well as to test the role of PTPN-1 gene expression and protein phosphatase-2 (PP2A), insulin receptor substrate (IRS) protein level in diabetes. Also, whether circRNA 0056618, miRNA-206, PTPN-1, IRS, and PP2A protein could be used as biomarkers for T2DM diagnosis and prognosis.

Patients and methods
This cross-sectional analytic study was carried out on 110 patients. Participants were divided into two equal groups: patients’ group (T2DM) and control group (normal participants). All participants were subjected to quantitative real-time PCR for assessed RNAs (circRNA 0056618, miRNA-206, and PTPn-1 gene expression), enzyme-linked immunosorbent assay technique for IRS, and PP2A protein levels.

Statistical analysis used
The Statistical Package for the Social Sciences (SPSS), version 28 was used to code and enter the data. All data will be presented as means and SDs. Correlations between quantitative variables will be done using Pearson correlation coefficient. Receiver operating characteristic (ROC) curve was constructed with area under the curve (AUC) analysis performed to detect the best cutoff value of significant parameters for detection of cases. P value will be considered significant less than 0.05.

Results and conclusion
There was a significant increase in circRNA 0056618 (P<0.001), PTPN-1 gene expression (P=0.002), and PP2A protein levels (P<0.001) and a significant decrease in miRNA-206 gene expression and IRS protein levels in diabetic cases (P<0.001) when compared with normal controls. There was a negative correlation between circRNA 0056618 and miRNA-206 and a positive correlation between circRNA 0056618 and PTPN-1. IRS at 0.840 showed 94.5% sensitivity and 90.9% specificity and AUC 0.905. PP2A at 0.868, sensitivity 96.4% and specificity 81.8%, and AUC 0.919. ROC curve for circRNA 0056618, at 0.882, sensitivity 89.1% and specificity 87.3%, and AUC 0.932, miRNA-206 at 0.785, sensitivity 85.5% and specificity 85.5%, and AUC 0.869. ROC curve for PTPN-1 at 0.556, sensitivity 67.3% and specificity 67.3%, and AUC 0.669.
We concluded that circRNA 0056618, PTPN-1, PP2A, miRNA-206 and IRS are considered diagnostic, predictive biomarkers in T2DM. Future RNA-based therapy approaches may benefit from an understanding of such new pathways.