bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mental illness among journalists: A systematic review
Authors: Aoki Yuta , Malcolm Estelle , Yamaguchi Sosei , Thornicroft Graham , Henderson Claire 
Published: March 2012

Background: Mass media depictions of people with mental illness have a strong influence on public attitudes, to the extent that changes in these depictions can reduce public stigmatization of people with such illness. Journalists’ mental health may influence their depiction of those with mental illness, but little is known about this. Aims: To investigate mental illness among journalists in five key areas: (1) journalists’ mental health status; (2) journalists’ personal attitudes towards mental illness; (3) attitudes and support journalists expect or have experienced from colleagues when they have a mental health problem; (4) effect of journalism’s professional culture on the course of mental illness; and (5) effect of journalism’s professional culture on mass media depictions of people with mental illness. Methods: We performed a systematic screening of MEDLINE, PsycINFO, EMBASE, Web of Science and the Cochrane Library regarding the study aims. Results: We identified 19, 12, seven and four studies for aims 1, 2, 3, and 4, respectively. No articles were found for aim 5. Conclusions: The prevalence of post-traumatic stress disorder (PTSD) among journalists is higher than that among the general population. Journalists have positive personal attitudes towards mental illness, but there are perceived workplace disincentives to disclose mental health problems.
Depression risks in mothers of children with developmental disabilities: A cross-cultural comparison of Brazil, Colombia, Malaysia and Thailand
Authors: Osada Hirokazu , Coelho de Amorim Annibal , Velosa Andrea , Wan Wong Poh , Lotrakul Panpimol , Hara Hitoshi 
Published: March 2012

Background: Compared with US or European countries, there are fewer mental health services for mothers of children with developmental disabilities in Latin American and/or Southeast Asian countries. Aims: To explore the risk of depression in mothers of children with developmental disabilities in countries with a lack of mental health professionals, we conducted cross-cultural comparisons for four countries: Brazil, Colombia, Malaysia and Thailand. Methods: Using the CES-D, we compared the participants’ depressive symptoms, by which we also estimated the probability of morbid depression. Results: In every country, participants tended to show depressive symptoms. In the CES-D total scores and the numbers of mothers who were observed to have a high level of depressive symptoms, there were significant differences among countries ( F = 4.36, p = .006; χ2 = 10.3, p = .015). Conclusions: Considering cultural models, we could apply evidence-based intervention to depressive mothers of children, and conduct intervention and treatment for those mothers and evaluate ways of providing better mental health services to these individuals.
Investigating the possibility of using TOEFL scores for university ESL decision-making: Placement trends and effect of time lag
Authors: Kokhan Kateryna 
Published: March 2012

The English Placement Test (EPT) at the University of Illinois at Urbana-Champaign (UIUC) is designed to provide an accurate placement (or exemption) of international students into the ESL writing and pronunciation classes. Over the last five years, UIUC has experienced an increase in the number of international students taking the EPT. Because of the costs of the EPT, various stakeholders have suggested using TOEFL as a substitute placement tool. The purpose of this research is to find out whether TOEFL iBT can serve as a suitable pre-screening tool for placement of international students into the ESL writing courses at UIUC. While there is a general statistically significant tendency that students with higher TOEFL iBT scores are placed into higher levels of ESL classes, there is no particular set of either total or section scores which can be used as a reliable criterion for dividing students into ESL classes without significant misplacement. Furthermore, the correlation between TOEFL iBT and the EPT shows a distinct pattern of time dependence: the correlation is stronger when the time gap between these tests is short but it dramatically decreases and even becomes slightly negative around Week 50; however, starting from the 50th week it increases. Some possible interpretations of the findings as well as recommendations for score users are discussed.
Psychiatric comorbidity and response to preventative therapy in the treatment of severe migraine trial
Authors: Seng Elizabeth K , Holroyd Kenneth A 
Published: March 2012

Introduction: Mood and anxiety disorders are comorbid with migraine and commonly assumed to portend a poor response to preventive migraine therapies. However, there is little evidence to support this assumption. Method: We examined impact of a mood and/or anxiety disorder diagnosis using American Psychiatric Association Diagnostic and Statistical Manual criteria on response to the three preventative migraine therapies evaluated in the Treatment of Severe Migraine trial (n = 177): β-blocker, behavioral migraine management, or behavioral migraine management +β-blocker. Daily diaries assessed migraine activity for the 16 months of the trial. The Migraine Specific Quality of Life Questionnaire and Headache Disability Inventory assessed headache-related disability at regular intervals. Mixed models for repeated measures examined changes in these three outcomes with preventative migraine therapy in participants with and without a mood or anxiety disorder diagnosis. Results: Participants with a comorbid mood or anxiety disorder diagnosis recorded larger reductions in migraine days (p <  .05) and larger reductions in the Migraine Specific Quality of Life Questionnaire (p < .001) and Headache Disability Inventory (p < .01) than did participants with neither diagnosis. Discussion: Significantly larger reductions in migraine activity and migraine-related disability were observed in participants with a mood and/or anxiety disorder diagnosis than in participants who did not receive either diagnosis.
Prognosis of cerebral vein thrombosis presenting as isolated headache: Early vs. late diagnosis
Authors: Gameiro Joana , Ferro José M , Canhão Patricia , Stam Jan , Barinagarrementeria Fernando , Lindgren Arne ,   the ISCVT (International Study on Cerebral Vein and Dural Sinus Thrombosis) investigators
Published: March 2012

Objective: To analyse the outcome of cerebral venous thrombosis (CVT) patients presenting with isolated headache, specifically to compare isolated headache patients with early vs. late CVT diagnosis. Method: In the International Study on Cerebral Vein and Dural Sinus Thrombosis (ISCVT) database we compared the outcome of patients with isolated headache and a CVT diagnosed early (≤7 days from onset) vs. late (>7 days). We retrieved 100 patients with isolated headache, 52 patients with early CVT diagnosis (early isolated headache) and 48 with late CVT diagnosis (late isolated headache). Results: Neurological worsening was more frequent within early isolated headache patients (23% vs. 8%) (p = 0.045). At the last follow-up (median 411 days), 93% patients had a complete recovery, and 4% were dead or dependent, with no significant difference between early isolated headache and late isolated headache. Conclusion: The outcome of CVT patients with isolated headache diagnosed early or late was similarly favourable, but there was a higher proportion of neurological worsening in the acute phase among early isolated headache patients, who need close neurological monitoring.
Primary continuous unilateral headaches: A nosologic model for hemicrania continua
Authors: Pareja Juan A , Cuadrado María-Luz , Fernández-de-las-Peñas César , Montojo Teresa , Álvarez Mónica , López-de-Silanes Carlos 
Published: March 2012

Background: Hemicrania continua was originally described as a strictly unilateral, continuous headache with an absolute response to indomethacin. Recognition of an increasing number of patients with the same clinical features except for a lack of response to indomethacin has generated controversy about whether the responsive/non-responsive phenotypes belong to the same disorder. Discussion: We suggest that the non-responsive phenotype should be differentiated from the original concept of hemicrania continua, because it probably indicates a separate type of headache of undetermined nature, i.e. hemicrania incerta . However, differentiating hemicrania incerta from hemicrania continua does not imply that the two headaches are unrelated. Both hemicranias may outline a continuum, giving rise to a broader diagnostic field. Conclusion: There seems to be a syndrome of ‘primary continuous unilateral headache’ with at least two distinctive categories: hemicrania continua and hemicrania incerta, which are differentiated by their respective response to indomethacin. This division means plurality but adds precision, and allows a clear-cut diagnosis of some controversial cases.
Cluster headache and sleep, is there a connection? A review
Authors: Barloese M , Jennum P , Knudsen S , Jensen R 
Published: March 2012

Purpose of review: Sleep and the chronobiological disease cluster headache are believed to be interconnected. Despite efforts, the precise nature of the relationship remains obscured. A better understanding of this relation may lead to more effective therapeutic regimes for patients suffering from this debilitating disease. This review aims to evaluate the existing literature on the subject of cluster headache and sleep. Latest findings: Several previous studies describe an association between episodic cluster headache and distinct macrostructural sleep phases. This association was not confirmed in a recent study of seven episodic cluster headache patients, but it was suggested that further studies into the correlation between cluster headache attacks and the microstructure of sleep are relevant. The connection between cluster headache and the hypocretins is currently under investigation. Summary: There is evidence in favour of an association between episodic cluster headache and REM sleep whereas no such relation to chronic cluster headache has been reported. Particular features in the microstructure of sleep and arousal mechanisms could play a role in the pathogenesis of cluster headache. Reports indicate that cluster headache and obstructive sleep apnoea are associated. Single cases show improvement upon treatment of sleep apnoea, but the causal relationship remains in question.
Spreading depolarizations in a case of migraine-related stroke
Authors: Santos Edgar , Sánchez-Porras Renán , Dohmen Christian , Hertle Daniel , Unterberg Andreas W , Sakowitz Oliver W 
Published: March 2012

Background: Cortical spreading depolarization (CSD) has been implicated in the pathophysiology of migraine with aura. Patients that suffer from this type of migraine have shown a higher risk of developing an ischaemic stroke. Case: A 42-year-old female exhibited reoccurring migraine attacks for the first time 1 month before suffering an ischaemic infarction. Imaging studies revealed an occlusion in the right middle cerebral artery. Other possible disorders were excluded. It was possible to register 20 CSDs, of which 12 coincided with high levels of glutamate and lactate/pyruvate ratio. Loss of electrocorticographic activity was observed for 89 hours after the 8th depolarization. Conclusions: Migraine with aura symptoms may be induced by CSDs triggered by hypoperfusion states. Our case supports the idea of the migraine with aura–stroke continuum.
Facial pain, scotomas and hemihypaesthesia as presenting symptoms of type A aortic dissection in a patient with migraine with aura
Authors: Seidel Stefan , Elwischger Kirsten , Wöber Christian 
Published: March 2012

We report the case of a 31-year-old man with a history of migraine with aura who was admitted to our emergency department because of a sudden onset of severe bilateral facial pain radiating bilaterally into the medial cervical region after defecation. The pain was accompanied by scotomas in the right visual field and hypaesthesia in both upper limbs. Imaging of the aorta and supra-aortic vessels revealed a type A aortic dissection. Subsequently, the patient received an aortic valve replacement and an aortic tube graft. After the surgery he experienced recurring visual disturbances with a sudden onset mimicking his migraine aura. Due to a new onset of atrial fibrillation, he was put on oral anticoagulants. At follow-up after 10 months he still reported episodic and mostly isolated visual auras with a gradual onset.
A 15-Year Prospective Epidemiological Account of Acute Traumatic Injuries During Official Professional Soccer League Matches in Japan
Authors: Aoki Haruhito , O’Hata Nozomu , Kohno Terushige , Morikawa Tsuguo , Seki Jun 
Published: March 2012

Background: Few prospective epidemiological studies on soccer match injuries have collected continuous data using subjects from the same group. Purpose: To investigate long-term injury-induced changes during official matches in the professional Japanese soccer league. Study Design: Descriptive epidemiological study. Methods: Acute injuries during official matches among top-division Japanese professional soccer leaguers were prospectively collected from 1993 to 2007. Injuries preventing player participation for 7 days or more were defined as a reportable injury. Interseasonal variations of injury rate (IR: injuries/1000/player hours) and injury pattern (type, location, circumstances, severity, injury time, positional role, and relationship to weather) were analyzed. Results: Throughout the study period, 2947 injuries from 3984 matches occurred. Mean annual IR was 21.77/1000 player hours, and annual variance showed gradual decrement throughout the study period. The proportion of injury type and location were not significantly changed. Sprain and contusion as injury type and thigh and ankle joint as location were the most common in every season. Contact-related injuries comprised 73.3% on average and were observed to occur more frequently during the last 15 minutes and extra time of match play. The proportion of foul play–related injuries showed a clear declining trend. The proportion of severe injury showed a sporadic increase from 2001 to 2004. The second, fifth, and sixth 15-minute match segments showed a higher IR. Goalkeepers had a lower IR versus other field players. Matches on rainy days resulted in a lower IR than did those held under other weather conditions. Conclusion: Long-term surveillance and statistical feedback of injury characteristics to organization members were considered effective in improving safer play awareness among players and for referees to reduce injury incidence, particularly foul play–related injuries.
Combined loss of cRel/p50 subunits of NF-κB leads to impaired innate host response in sepsis
Authors: Courtine Emilie , Cagnard Nicolas , Mazzolini Julie , Antona Marion , Pène Frédéric , Fitting Catherine , Jacques Sébastien , Rousseau Christophe , Niedergang Florence , Gerondakis Steve , Chiche Jean-Daniel , Ouaaz Fatah , Mira Jean-Paul 
Published: March 2012

NF-κB, which comprises homo- and hetero-dimers of the five members of the Rel family, plays a crucial role in immunity to infection. The cRel and p50 subunits have been implicated in the development and function of the immune cells, but their in vivo importance remains poorly explored in sepsis. We aimed to study the impact of the combined loss of these two subunits on the innate response to infection in a cecal ligation and puncture model of sepsis. We have explored the possible defects in host defense, including pathogen clearance, bacterial phagocytosis and cytokine plasma release. We also performed gene profiling of cRel−/−p50−/− and wild-type LPS-stimulated peritoneal macrophages. Deficiency of cRel and p50 led to enhanced mortality to sepsis that was associated with defective macrophages phagocytosis, decreased bacterial clearance and moderate cytokine response. Transcription profile analysis revealed a common inflammatory response but a significant down-regulated transcription of genes encoding for pathogen recognition receptors and antimicrobial molecules, supporting the in vivo findings in mice. In conclusion, the cRel and p50 subunits of NF-κB play an important combined role in the innate response and are crucial for survival and pathogen clearance in polymicrobial sepsis.
The pan-deacetylase inhibitor panobinostat induces cell death and synergizes with everolimus in Hodgkin lymphoma cell lines
Authors: Lemoine Manuela , Derenzini Enrico , Buglio Daniela , Medeiros L. Jeffrey , Davis R. Eric , Zhang Jiexin , Ji Yuan , Younes Anas 
Published: March 2012

AbstractThe pan-deacetylase inhibitor panobinostat (LBH589) recently has been shown to have significant clinical activity in patients with relapsed Hodgkin lymphoma, but its mechanism of action in Hodgkin lymphoma remains unknown. In this study, we demonstrate that panobinostat has potent antiproliferative activity against Hodgkin lymphoma–derived cell lines. At the molecular level, panobinostat activated the caspase pathway, inhibited STAT5 and STAT6 phosphorylation, and down-regulated hypoxia-inducible factor 1 α and its downstream targets, glucose transporter 1 (GLUT1) and vascular endothelial growth factor. Paradoxically, panobinostat inhibited LKB1 and AMP-activated protein kinase, leading to activation of mammalian target of rapamycin (mTOR) that promotes survival. Combining panobinostat with the mTOR inhibitor everolimus (RAD001) inhibited panobinostat-induced mTOR activation and enhanced panobinostat antiproliferative effects. Collectively, our data demonstrate that panobinostat is a potent deacetylase inhibitor against Hodgkin lymphoma–derived cell lines, and provide a mechanistic rationale for combining panobinostat with mTOR inhibitors for treating Hodgkin lymphoma patients. Furthermore, the effect of panobinostat on GLUT1 expression suggests that panobinostat may modulate the results of clinical diagnostic imaging tests that depend of functional GLUT1, such as fluorodeoxyglucose positron emission tomography.
Leukemia-initiating cells of patient-derived acute lymphoblastic leukemia xenografts are sensitive toward TRAIL
Authors: Castro Alves Catarina , Terziyska Nadia , Grunert Michaela , Gündisch Sibylle , Graubner Ulrike , Quintanilla-Martinez Leticia , Jeremias Irmela 
Published: March 2012

Abstract
Cancer stem cells represent the most important target cells for antitumor therapy. TRAIL (TNF-related apoptosis-inducing ligand) is a potential anticancer agent that induces apoptosis in a wide variety of tumor cells, but its ability to target cancer stem cells is currently unknown. Here we investigated whether TRAIL targets leukemia-initiating cells. Limiting dilution transplantation assays were performed on xenografts from pediatric patients with precursor B-cell acute lymphoblastic leukemia (pre-B ALL) in NSG mice. In vitro treatment of xenograft cells with TRAIL significantly reduced and delayed their engraftment and procrastinated animal death from leukemia. Systemic TRAIL treatment of mice injected with patient-derived pre-B ALL xenograft cells abrogated leukemia in 3 of 5 mice in 1 sample. In conclusion, our data suggest that TRAIL targets leukemia-initiating cells derived from pre-B ALL xenografts in vitro and in vivo, and hence constitutes an attractive candidate drug for treatment of ALL.
The FA pathway counteracts oxidative stress through selective protection of antioxidant defense gene promoters
Authors: Du Wei , Rani Reena , Sipple Jared , Schick Jonathan , Myers Kasiani C. , Mehta Parinda , Andreassen Paul R. , Davies Stella M. , Pang Qishen 
Published: March 2012

Abstract
Oxidative stress has been implicated in the pathogenesis of many human diseases including Fanconi anemia (FA), a genetic disorder associated with BM failure and cancer. Here we show that major antioxidant defense genes are down-regulated in FA patients, and that gene down-regulation is selectively associated with increased oxidative DNA damage in the promoters of the antioxidant defense genes. Assessment of promoter activity and DNA damage repair kinetics shows that increased initial damage, rather than a reduced repair rate, contributes to the augmented oxidative DNA damage. Mechanistically, FA proteins act in concert with the chromatin-remodeling factor BRG1 to protect the promoters of antioxidant defense genes from oxidative damage. Specifically, BRG1 binds to the promoters of the antioxidant defense genes at steady state. On challenge with oxidative stress, FA proteins are recruited to promoter DNA, which correlates with significant increase in the binding of BRG1 within promoter regions. In addition, oxidative stress-induced FANCD2 ubiquitination is required for the formation of a FA-BRG1–promoter complex. Taken together, these data identify a role for the FA pathway in cellular antioxidant defense.
Expression of ABO blood-group genes is dependent upon an erythroid cell–specific regulatory element that is deleted in persons with the Bm phenotype
Authors: Sano Rie , Nakajima Tamiko , Takahashi Keiko , Kubo Rieko , Kominato Yoshihiko , Tsukada Junichi , Takeshita Haruo , Yasuda Toshihiro , Ito Kazuto , Maruhashi Takayuki , Yokohama Akihiko , Isa Kazumi , Ogasawara Kenichi , Uchikawa Makoto 
Published: March 2012

AbstractThe ABO blood group is of great importance in blood transfusion and organ transplantation. However, the mechanisms regulating human ABO gene expression remain obscure. On the basis of DNase I–hypersensitive sites in and upstream of ABO in K562 cells, in the present study, we prepared reporter plasmid constructs including these sites. Subsequent luciferase assays indicated a novel positive regulatory element in intron 1. This element was shown to enhance ABO promoter activity in an erythroid cell–specific manner. Electrophoretic mobility–shift assays demonstrated that it bound to the tissue-restricted transcription factor GATA-1. Mutation of the GATA motifs to abrogate binding of this factor reduced the regulatory activity of the element. Therefore, GATA-1 appears to be involved in the cell-specific activity of the element. Furthermore, we found that a partial deletion in intron 1 involving the element was associated with Bm phenotypes. Therefore, it is plausible that deletion of the erythroid cell–specific regulatory element could down-regulate transcription in the Bm allele, leading to reduction of B-antigen expression in cells of erythroid lineage, but not in mucus-secreting cells. These results support the contention that the enhancer-like element in intron 1 of ABO has a significant function in erythroid cells.