bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of redox modulation by inhibition of thioredoxin reductase on radiosensitivity and gene expression
Authors: Selenius Markus , Hedman Mattias , Brodin David , Gandin Valentina , Rigobello Maria Pia , Flygare Jenny , Marzano Christine , Bindoli Alberto , Brodin Ola , Björnstedt Mikael , Fernandes Aristi P. 
Published: October 2011

AbstractThe thioredoxin system is a promising target when aiming to overcome the problem of clinical radiation resistance. Altered cellular redox status and redox sensitive thiols contributing to induction of resistance strongly connect the ubiquitous redox enzyme thioredoxin reductase (TrxR) to the cellular response to ionizing radiation. To further investigate possible strategies in combating clinical radiation resistance, human radio‐resistant lung cancer cells were subjected to a combination of single fractions of γ‐radiation at clinically relevant doses and non‐toxic levels of a well‐characterized thioredoxin reductase inhibitor, the phosphine gold(I) compound [Au(SCN)(PEt3)]. The combination of the TrxR‐inhibitor and ionizing radiation reduced the surviving fractions and impaired the ability of the U1810 cells to repopulate by approximately 50%. In addition, inhibition of thioredoxin reductase caused changes in the cell cycle distribution, suggesting a disturbance of the mitotic process. Global gene expression analysis also revealed clustered genetic expression changes connected to several major cellular pathways such as cell cycle, cellular response to stress and DNA damage. Specific TrxR‐inhibition as a factor behind the achieved results was confirmed by correlation of gene expression patterns between gold and siRNA treatment. These results clearly demonstrate TrxR as an important factor conferring resistance to irradiation and the use of [Au(SCN)(PEt3)] as a promising radiosensitizing agent.
Toxoplasma gondii excretory secretory antigenic proteins of diagnostic potential
Authors: SAADATNIA GEITA , MOHAMED ZEEHAIDA , GHAFFARIFAR FATEMEH , OSMAN EMELIA , MOGHADAM ZOHREH KAZEMI , NOORDIN RAHMAH 
Published: October 2011

Saadatnia G, Mohamed Z, Ghaffarifar F, Osman E, Kazemi Moghadam Z, Noordin R. Toxoplasma gondii excretory secretory antigenic proteins of diagnostic potential. APMIS 2012; 120: 47–55.Infection with Toxoplasma gondii is widespread and important in humans, especially pregnant women and immunosuppressed patients. A panel of tests is usually required for diagnosis toxoplasmosis. Excretory secretory antigen (ESA) is highly immunogenic, and thus it is a good candidate for investigation into new infection markers. ESA was prepared from tachyzoites of RH strain of T. gondii by mice intraperitoneal infection. Sera were obtained from several categories of individuals who differed in their status of anti‐Toxoplasma IgM, IgG and IgG avidity antibodies. The ESA was subjected to SDS‐PAGE, two‐dimensional gel electrophoresis and Western blot analysis. Antigenic bands of approximate molecular weights of 12, 20 and 30 kDa, when probed with anti‐human IgM‐HRP and IgA‐HRP, showed good potential as infection markers. The highest sensitivity of the bands was 98.7% with combination of IgM and IgA blots with sera of patients with anti‐Toxoplasma IgM+ IgG+. The specificities were 84% and 70% with sera from other infections and healthy controls in IgM blots and IgA blots respectively. By mass spectrometry, the 12 kDa protein was identified as thioredoxin. The two top proteins identified for 20 kDa molecule were microneme protein 10 and dense granule protein 7; whereas that for 30 kDa were phosphoglycerate mutase 1 and phosphoglycerate mutase.
A 1‐Year Prospective Study on Co‐Axis® Implants Immediately Loaded with a Full Ceramic Crown
Authors: Vandeweghe Stefan , Cosyn Jan , Thevissen Eric , Van den Berghe Linda , De Bruyn Hugo 
Published: October 2011

ABSTRACTIntroduction: The Co‐Axis® implant (Southern Implants®, Irene, South Africa) has a 12‐degree angle in the implant neck to overcome angulation problems.Aim: To examine bone loss, peri‐implant health, and aesthetical outcome after 1‐year follow‐up.Materials and Methods: Fifteen single implants were placed in 14 patients in the premaxilla and immediately loaded with a screw‐retained full ceramic crown. Periapical radiographs and standardized photographs were taken to determine bone loss and soft tissue changes. Plaque and bleeding levels were assessed. Patients' satisfaction was measured using the Oral Health Impact Profile‐14 questionnaire.Results: After 1 year, all implants survived and mean bone loss was 1.20 mm, with no significant changes after 6 months. Plaque levels were low and no significant changes were observed. Bleeding levels decreased during the initial 3 months, but were constant thereafter. Before final torqueing was performed after 6 months, four cases of screw loosening occurred. Also, one crown had a piece of porcelain chipped off. Patients reported an overall increase in well‐being. A mean midfacial recession of 0.37 mm was observed. The mesial papilla showed a slight increase of 0.14 mm, while the distal papilla decreased 0.35 mm.Conclusion: With 100% survival and stable bone levels after 6 months, the Co‐Axis implant showed a good clinical outcome when immediately loaded. The use of a full ceramic crown as a first and final restoration resulted in a good aesthetic outcome with few changes in papilla fill, although midfacial soft tissue was stable only after 1 year.
Increased expression of NOR‐1 mRNA in the skeletal muscles of cold‐exposed neonatal chicks
Authors: IJIRI Daichi , MATSUBARA Tomoko , KANAI Yukio , HIRABAYASHI Miho 
Published: October 2011

ABSTRACTNuclear receptor subfamily 4, group A (NR4A) subgroup orphan receptors are rapidly induced by various physiological stimuli and have been suggested to regulate oxidative metabolism and muscle mass in mammalian skeletal muscle. The results showed that the NR4A subgroup orphan receptor, NOR‐1 (NR4A3), was acutely increased in skeletal muscles of neonatal chicks in response to short‐term cold exposure. The increased NOR‐1 gene expression was concomitant with cold‐induced changes in gene expression of both myostatin and proliferator‐activated receptor‐gamma coactivator‐1 (PGC‐1α), and the increase in skeletal muscle mass. These observations suggest that NOR‐1 might play a role in controlling skeletal muscle growth in cold‐exposed neonatal chicks.
Association between energy status early postpartum and subsequent embryonic mortality in high‐yielding recipient cows
Authors: SENOSY Waleed , ZAIN Alaa Eldin , ABDEL‐RAZEK Abdel‐Razek Khalifa , UCHIZA Michiko , TAMEOKA Nanae , IZAIKE Yoshiaki , OSAWA Takeshi 
Published: October 2011

ABSTRACTHigh‐yielding Holstein‐Friesian recipients (n = 43) were used in order to investigate the relation between energy balance status during the early postpartum period and subsequent embryonic mortality after transferring good‐quality frozen embryos. Blood samples were collected during the second, third, fourth, fifth, sixth and seventh weeks postpartum in order to measure energy status indicators. These indicators include β hydroxyl butyric acid (BHBA), non‐esterified fatty acid (NEFA), total cholesterol (T‐chol), glucose and blood urea nitrogen (BUN). Moreover, body condition scores (BCS) were assessed during the same period. Pregnancy diagnosis by ultrasonography at the 28th day postestrus and embryo viability was ascertained until 45 days postestrus in order to detect late embryonic mortality (LEM). The pregnancy rate on day 28 was 44.2% (19/43); however, five cows (11.6%) experienced LEM by day 45. Based on the non‐return rate at day 24, non‐pregnant animals, as diagnosed by ultrasonography, were allocated into animals with longer estrus intervals than 24 days (32.5%; mid‐embryonic mortality (MEM) group) and animals returning to estrus by day 24 postestrus (23.5%; early embryonic mortality (EEM) group). At week 5 postpartum, BCS was significantly (P < 0.05) lower in the LEM group than that of pregnant (PREG), EEM and MEM groups. NEFA was significantly higher in animals that experienced LEM (LEM group) at week 7 postpartum (289.6 ± 47.0 µEq/L; P < 0.01) than that of PREG (196.8 ± 16.0 µEq/L), EEM (157.2 ± 18.6 µEq/L) and MEM groups (191.5 ± 14.4 µEq/L). In conclusion, lower BCS at week 5 postpartum and higher NEFAs at week 7 postpartum may be associated with subsequent LEM in high‐yielding recipient cows.
Fermentation quality and chemical composition of shrub silage treated with lactic acid bacteria inoculants and cellulase additives
Authors: SUN Qizhong , GAO Fengqin , YU Zhu , TAO Ya , ZHAO Shufen , CAI Yimin 
Published: October 2011

ABSTRACTEffects of lactic acid bacteria (LAB) inoculants and cellulase additives on fermentation quality and chemical compositions of shrub silages were studied by using a small‐scale fermentation system. Two LAB inoculants of Qingbao (Lactobacillus plantarum, Pediococcus acidilacticii, Lactobacillus casei and Clostridium phage) and Caihe (Lactobacillus plantarum, Lactobacillus brevis and Pediococcus acidilactici) and a commercial cellulase made from Trichoderma reesei were used as additives for intermediate pea‐shrub, rush bushclover, arborescent ceratoides and shrubby silage preparation. The crude protein, neutral detergent fiber and water‐soluble carbohydrate contents of the four shrub materials were 10.1–14.2, 62.6–67.2 and 1.9–3.5% on a dry matter basis, respectively. All shrub silages had pH 3.40–4.43, ammonia‐N 0.1–0.2% g/kg and lactic acid 1.3–2.9% on a fresh matter basis. The silage quality of LAB‐inoculated silages did not have a greater effect than control silages, except shrubby silage preparation. Silages treated with the cellulase, the pH of rush bushclover and shrubby sweetvetch silage were significantly (P < 0.05) lower and the lactic acid content were significantly (P < 0.05) higher than the control silages. The results confirmed that shrub contained a relatively high content of crude protein; its silages can be preserved in good quality, and they are new potential resources for livestock feed.
Effects of porcine leptin receptor gene polymorphisms on backfat thickness, fat area ratios by image analysis, and serum leptin concentrations in a Duroc purebred population
Authors: UEMOTO Yoshinobu , KIKUCHI Takashi , NAKANO Hikaru , SATO Shuji , SHIBATA Tomoya , KADOWAKI Hiroshi , KATOH Kazuo , KOBAYASHI Eiji , SUZUKI Keiichi 
Published: October 2011

ABSTRACTThe leptin receptor (LEPR) gene is considered a candidate gene for fatness traits. It is located on SSC 6 in a region in which quantitative trait loci (QTLs) for backfat thickness (BF), fat area ratios, and serum leptin concentration (LEPC) have previously been detected in a Duroc purebred population. The objectives of the present study were to identify porcine LEPR polymorphisms and examine the effects of LEPR polymorphisms on fatness traits in this same population. The Duroc pigs (226 to 953 pigs) were evaluated for BF, fat area ratios using image analysis, and LEPC. A total of seven single nucleotide polymorphisms (SNPs) in the full‐length LEPR coding region were identified in pigs from the base population. Four non‐synonymous SNPs of the LEPR gene and 15 microsatellite markers on SSC 6 were then genotyped in all pigs. During candidate gene analysis, we detected significant effects of the non‐synonymous SNP c.2002C>T in exon 14 on all traits. In fine mapping analysis, significant QTLs for BF, fat area ratios, and LEPC were detected near the LEPR gene in the same region. These results indicated that the c.2002C>T SNP of LEPR has a strong effect on BF, fat area ratios and LEPC.
Nutritional status, dietary intake and oral quality of life in elderly complete denture wearers
Authors: Cousson Pierre Yves , Bessadet Marion , Nicolas Emmanuel , Veyrune Jean‐Luc , Lesourd Bruno , Lassauzay Claire 
Published: October 2011

doi: 10.1111/j.1741‐2358.2011.00545.xNutritional status, dietary intake and oral quality of life in elderly complete denture wearersBackground and objective:  The prevalence of malnutrition increases with age because of many factors. Edentulousness leads to the avoidance of many types of foods. The aim of this study was to determine whether elderly complete denture wearers have a higher risk of malnutrition than dentate controls.Material and methods:  A Mini‐Nutritional Assessment (MNA) and a 3‐day dietary record were compiled for a group of fully dentates (21 women and 29 men; mean age 70.1 ± 6.1) and for a group of complete denture wearers (31 women and 16 men; mean age 70.1 ± 8.1). Socio‐demographic data and scores on the General Oral Health Assessment Index (GOHAI) questionnaire were collected.Results:  Inter‐group comparison of MNA scores showed that more subjects in the edentulous group (21.3%) risked malnutrition than in the dentate group (0%). The variability of the MNA could be explained for 22% by dental status, 7% by loneliness and 4% by the GOHAI score (regression analysis). Both groups had insufficient energy intakes and deficits in vitamins and micronutrients; moreover, edentulous subjects had lower intakes than dentate subjects.Conclusion:  The use of conventional dentures increases the risk of malnutrition in the elderly.
Compressive strains and displacement in a partially dentate lower jaw rehabilitated with two different treatment modalities
Authors: Tihacek Sojic Ljiljana , Lemic Aleksandra Milic , Tanasic Ivan , Mitrovic Nenad , Milosevic Milos , Petrovic Aleksandar 
Published: October 2011

doi: 10.1111/j.1741‐2358.2011.00572.xCompressive strains and displacement in a partially dentate lower jaw rehabilitated with two different treatment modalitiesBackground:  Understanding of the biomechanical consequences of the stresses generated to the supporting bone during occlusal loading is significant for improving the design and clinical planning process in partial edentulism therapy.Objective:  The aim of this study was to analyse the distribution of strain and displacement on the partially dentate lower jaw rehabilitated with an partial denture (RPD) and to compare it to the strain and displacement distribution on a partially dentate lower jaw rehabilitated with a cantilever fixed partial denture (FPD).Material and methods:  The experimental models were a partially dentate mandible with full‐arch PFM crowns and RPD and a partially dentate mandible rehabilitated with a full‐arch cantilever FPD. Strains and displacement were measured using the Digital Image Correlation Method.Results:  Displacement values of the first experimental model ranged from 0.31 to 0.54 mm with strains from 1.35 to 2.34%. Analysis of the second experimental model results showed displacement values from 0 to 0.34 mm, while strains were in the range of 0–1.40%.Conclusion:  Higher displacements and strains of bone tissue were observed below the RPD, especially in the region of the distal abutment and distal portion of the free‐end saddle. Strains within bone and the bone‐denture contact area were mostly influenced by the teeth and denture vertical displacement.
Looking inside the nest: the hidden structure of the merger galaxy NGC 1316 (Fornax A)
Authors: Beletsky Y. , Gadotti D. A. , Moiseev A. , Alves J. , Kniazev A. 
Published: October 2011

ABSTRACT
We present an analysis of the circumnuclear structure of NGC 1316 using both near-infrared imaging and stellar kinematics. 2D decomposition of the images suggests the presence of a structure that resembles inner gaseous spiral arms, at about 5–15 arcsec from the centre (≈500 to 1500 pc). We also find a disc-like stellar structure with radius less than 200 pc. Analysis of previously published SINFONI integral field kinematics data indicates a kinematically decoupled core in the same spatial scale, further evidence that indeed the nuclear stellar structure found is a kinematically cold stellar disc. We suggest that both newly found structural components are the result of a recent accretion of a companion galaxy.
The Hubble Space Telescope colours of high-redshift Population III galaxies with strong Lyα emission
Authors: Zackrisson Erik , Inoue Akio K. , Rydberg Claes-Erik , Duval Florent 
Published: October 2011

ABSTRACT
Population III (pop III) galaxies, made partly or exclusively of metal-free stars, are predicted to exist at high redshifts and may produce very strong Lyα emission. A substantial fraction of these Lyα photons are likely absorbed in the intergalactic medium at z &gt; 6, but recent simulations suggest that significant Lyα emission may be detectable up to z≈ 8.5, i.e. well into the reionization epoch. Here, we argue that high-redshift pop III galaxies with strong Lyα emission can be identified in Hubble Space Telescope imaging data because of their unusual colours. We quantify this effect in some of the filters used in Y-band dropout searches for galaxies at z≈ 8 and find that pop III galaxies with high Lyα fluxes may exhibit much bluer J−H colours at z≈ 8–10 than any normal type of galaxy at these redshifts. This colour signature can arise even if pop III stars account for as little as ∼10−3 to 10−2 of the stellar mass in these galaxies. Some of the anomalously blue objects reported in current Y-band dropout samples do in fact meet the colour criteria for Lyα-emitting pop III galaxies.
Detection of radio emission from a nova-like cataclysmic variable: evidence of jets?
Authors: Körding E. G. , Knigge C. , Tzioumis T. , Fender R. 
Published: October 2011

ABSTRACT
Jets have been detected in many accreting compact objects, and recently indications for jets have finally been found for transient cataclysmic variables (dwarf novae). However, so far, there have been no convincing reports of radio emission from white dwarfs undergoing stable disc accretion at a high rate, the so-called nova-like variables. Here, we present the first reproducible radio detection of a nova-like cataclysmic variable. The accretion rate and the distance of the detected source V3885 Sgr are comparable to the dwarf nova SS Cyg during its plateau phase. The detected radio emission is also of a similar level, although the source seems to show a steep spectrum. Besides V3885 Sgr, we have also observed IX Vel as well as reanalysed the available data for AC Cnc. Due to dynamic range limitations for IX Vel, we were not able to reach the required sensitivity and only obtained an upper limit. For AC Cnc we cannot confirm the previous detection. We discuss the detection of V3885 Sgr in the context of other types of accreting objects and conclude that the most likely source of the radio emission is optically thin synchrotron emission originating in a jet. Thus, tentative evidence for jets has now been found in both steady and transient CVs, making a universal connection between disc accretion and jet formation possible.
THE REMOVAL OF PSYCHROTROPIC SPORES FROM MILK PROTEIN ISOLATE FEEDS USING TUBULAR CERAMIC MICROFILTERS
Authors: HEAD LAURA E. , BIRD MICHAEL R. 
Published: October 2011

ABSTRACTThe application of microfiltration (MF) to remove spores from high solids content (5–15 wt %) Milk protein isolate (MPI) solutions are reported as a possible alternative process to pasteurization. MPI feeds were inoculated with Bacillus mycoides spores as a safer alternative to Bacillus cereus found in dairy feeds. The protocol used led to successful filtration outcomes for 5 and 10 wt % feeds, with the most encouraging result for 10 wt % found using a 12.0‐µm membrane and 1.4 m/s cross‐flow velocity. This produced a flux of 123 L m2/hr (LMH), a 90% protein transmission and a 2.6 log spore reduction. The filtration of 15 wt % MPI solutions proved more challenging. The best set of results for this feed was also obtained using a 12.0‐µm membrane at 1.4 m/s, producing a flux of 27 LMH, 96.5% protein transmission and a 2.1 log spore reduction. These results indicate that large pore ceramic MF may be a suitable technology to replace or augment pasteurization for high solids content dairy feeds.PRACTICAL APPLICATIONSMilk and other dairy products are highly nutritious media, in which microorganisms can cause spoilage. The use of microfiltration (MF) as an alternative to pasteurization to reduce the microbial load of raw skim milk is a well‐established technology being used to produce commercially available products such as Cravendale® milk. However, its application in reducing bacteria from highly viscous dairy‐based solutions has not become established because of issues of low flux and high fouling tendency. The novelty in this study is the filtration of high solids content (up to 15 wt %) MPI streams to reduce microbial load.MF represents an attractive alternative processing technique to pasteurization for the treatment of dairy products. Whereas pasteurization only destroys heat‐sensitive spoilage and pathogenic bacteria, MF is capable of removing all types of microorganisms including thermoduric and spore‐forming bacteria. Moreover, MF can be carried out using lower temperatures than those used during pasteurization.
Does HLA‐B*2706 protect against ankylosing spondylitis? A meta‐analysis
Authors: Van GAALEN Floris Alexander 
Published: October 2011

AbstractThe human leukocyte antigen (HLA)‐B*2706 is a relatively rare subtype of HLA‐B27. In contrast to most HLA‐B27 subtypes, some studies have reported HLA‐B*2706 to be protective against ankylosing spondylitis (AS). A systematic review and a meta‐analysis of available studies was performed to investigate the association of HLA‐B*2706 with AS. After literature review a random effect meta‐analysis was performed. No studies were found comparing the frequency of HLA‐B*2706 in AS patients and controls. Meta‐analysis of seven studies using HLA‐B27‐positive AS patients and controls showed a protective effect of HLA‐B*2706 on development of AS in HLA‐B27 individuals (odds ratio = 0.128, 95% CI = 0.043–0.378, P < 0.001). The results of the meta‐analysis of HLA‐B*2706 in HLA‐B27‐positive patients and controls is preliminary evidence of a protective effect of HLA‐B*2706 against AS in the population. There is a clear need for additional studies on HLA‐B*2706 in AS. Due to the fact that HLA‐B*2706 is more or less restricted to Southeast Asia, researchers in this part of the world may have an essential role in performing these studies.
The Structural Role of Zn in Nuclear Waste Glasses
Authors: Cassingham Nathan J. , Stennett Martin C. , Bingham, Paul A. , Hyatt Neil C. , Aquilanti Giuliana 
Published: October 2011

Addition of ZnO and CaO to current United Kingdom high level nuclear waste (HLW) glass frits is currently under consideration with the aim of improving processing behavior and aqueous durability. This study was performed in order to better understand the structural role of Zn in model U.K. HLW glasses and, in particular, the role of Zn as a network modifier, intermediate, or former in such materials. Zinc K‐edge X‐ray absorption spectroscopy was applied to simple soda‐lime‐silicate glasses doped with ZnO and on model inactive U.K. HLW glasses consisting of simulated Magnox and Blend (25 wt% Magnox + 75 wt% ThORP reprocessing waste) wastes. X‐ray absorption near edge and extended X‐ray absorption fine structure spectroscopy provided conclusive evidence that Zn occurs in four‐fold coordination with Zn–O contact distances of 1.95 ± 0.01 Å in all glasses studied. Analysis of the extended X‐ray absorption fine structure data also indicates the presence of short range order with Si next nearest neighbor atoms present at a Zn–Si contact distance of 3.58 ± 0.03 Å.