bluuebunny/crossref_metadata_2025_split huggingface dataset:
ChemInform Abstract: Thiosugars. Part 8. Preparation of New 4′‐Thio‐L‐lyxo Pyrimidine Nucleoside Analogues.
Authors: Wirsching Joern , Voss Juergen , Adiwidjaja Gunadi , Balzarini Jan , De Clercq Erik 
Published: May 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis of 5‐Alkenylated D4T Analogues via the Pd‐Catalyzed Cross‐Coupling Reaction.
Authors: Ciurea A. , Fossey C. , Benzaria S. , Gavrilliu D. , Delbederi Z. , Lelong B. , Laduree D. , Aubertin A. M. , Kirn A. 
Published: May 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: “Fleximers”. Design and Synthesis of Two Novel Split Nucleosides.
Authors: Seley Katherine L. , Zhang Lian , Hagos Asmerom 
Published: May 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis of 4(5)‐(α‐D‐Xylofuranosyl)imidazole (V) Starting from L‐Arabinose (I): Mitsunobu Cyclization via C4′‐Oxyphosphonium Intermediate.
Authors: Araki Lisa , Harusawa Shinya , Fukuda Mayuko , Kurihara Takushi 
Published: May 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Total Synthesis of Nucleobase‐Modified Adenophostin A Mimics.
Authors: Shuto Satoshi , Horne Graeme , Marwood Rachel D. , Potter Barry V. L. 
Published: May 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: First Highly Stereoselective Synthesis of (+)‐Dihydrosesamin, a Trisubstituted Tetrahydrofuran‐Type of Lignan, by Using Highly erythro‐Selective Aldol Condensation.
Authors: Yamauchi Satoshi , Tanaka Teruhisa , Kinoshita Yoshiro 
Published: May 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: A Convenient and Asymmetric Protocol for the Synthesis of Natural Products Containing Chiral Alkyl Chains via Zr‐Catalyzed Asymmetric Carboalumination of Alkenes. Synthesis of Phytol and Vitamins E and K.
Authors: Huo Shouquan , Negishi Ei‐ichi 
Published: May 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Liposidomycins — Synthetic Studies Towards the Ribosyldiazepanone Moiety.
Authors: Gravier‐Pelletier Christine , Milla Maria , Le Merrer Yves , Depezay Jean‐Claude 
Published: May 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Studies on the Chemical Transformations of Rotenoids. Part 6. Synthesis and Antitumor‐Promoting Activity of [1]Benzofuro[2,3‐d]pyridazines Fused with 1,2,4‐Triazole, 1,2,4‐Triazine and 1,2,4‐Triazepine.
Authors: Nagai Shin‐ichi , Takemoto Satoshi , Ueda Taisei , Mizutani Kanako , Uozumi Yasuhiro , Tokuda Harukuni 
Published: May 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Substructure, Subgraph, and Walk Counts as Measures of the Complexity of Graphs and Molecules.
Authors: Ruecker Gerta , Ruecker Christoph 
Published: May 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Evaluation of a 1H—13C NMR Spectral Library.
Authors: Smith S. K. , Cobleigh J. , Svetnik V. 
Published: May 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Identification of a Series of PPARγ/δ Dual Agonists via Solid‐Phase Parallel Synthesis.
Authors: Liu Kevin G. , Lambert Millard H. , Leesnitzer Lisa M. , Oliver Jr. William , Ott Ronda J. , Plunket Kelli D. , Stuart Ludwig W. , Brown Peter J. , Willson Timothy M. , Sternbach Daniel D. 
Published: May 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Mesotunnels on the Silica Wall of Ordered SBA‐15 to Generate Three‐Dimensional Large‐Pore Mesoporous Networks.
Authors: Fan Jie , Yu Chengzhong , Wang Limin , Tu Bo , Zhao Dongyuan , Sakamoto Yasuhiro , Terasaki Osamu 
Published: May 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Electrochemical Hydrogen Storage in MoS2 Nanotubes.
Authors: Chen Jun , Kuriyama Nobuhiro , Yuan Huatang , Takeshita Hiroyuki T. , Sakai Tetsuo 
Published: May 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Directed Evolution and Biocatalysis
Authors: Powell Keith A. , Ramer Sandra W. , del Cardayre Stephen B. , Stemmer Willem P. C. , Tobin Matthew B. , Longchamp Pascal F. , Huisman Gjalt W. 
Published: May 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Conformational Space and Dynamic Stereochemistry of Overcrowded Homomerous Bistricyclic Aromatic Enes — A Theoretical Study
Authors: Biedermann P. Ulrich , Stezowski John J. , Agranat Israel 
Published: May 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Self‐illuminating in vivo lymphatic imaging using a bioluminescence resonance energy transfer quantum dot nano‐particle
Authors: Kosaka Nobuyuki , Mitsunaga Makoto , Bhattacharyya Sukanta , Miller Steven C. , Choyke Peter L. , Kobayashi Hisataka 
Published: May 2010

AbstractAutofluorescence arising from normal tissues can compromise the sensitivity and specificity of in vivo fluorescence imaging by lowering the target‐to‐background signal ratio. Since bioluminescence resonance energy transfer quantum dot (BRET‐QDot) nano‐particles can self‐illuminate in near‐infrared in the presence of the substrate, coelenterazine, without irradiating excitation lights, imaging using BRET‐QDots does not produce any autofluorescence. In this study, we applied this BRET‐QDot nano‐particle to the in vivo lymphatic imaging in mice in order to compare with BRET, fluorescence or bioluminescence lymphatic imaging. BRET‐QDot655, in which QDot655 is contained as a core, was injected at different sites (e.g. chin, ear, forepaws and hind paws) in mice followed by the intravenous coelenterazine injection, and then bioluminescence and fluorescence imaging were serially performed. In all mice, each lymphatic basin was clearly visualized in the BRET imaging with minimal background signals. The BRET signal in the lymph nodes lasted at least 30 min after coelenterazine injections. Furthermore, the BRET signal demonstrated better quantification than the fluorescence signal emitting from QDot655, the core of this BRET particle. These advantages of BRET‐QDot allowed us to perform real‐time, quantitative lymphatic imaging without image processing. BRET‐Qdots have the potential to be a robust nano‐material platform for developing optical molecular imaging probes. Copyright © 2010 John Wiley & Sons, Ltd.
Intravenous delivery of the plasma fraction of stored packed erythrocytes promotes pancreatic cancer growth in immunocompetent mice
Authors: Barnett Carlton C. , Beck Adam W. , Holloway Shane E. , Kehler Marguerite , Schluterman Marie K. , Brekken Rolf A. , Fleming Jason B. , Silliman Christopher C. 
Published: May 2010

AbstractBACKGROUND:Perioperative blood transfusion in pancreatic cancer patients has been linked to decreased survival; however, a causal mechanism has not been determined. During the processing and storage of packed erythrocytes, biologically active molecules accumulated in the acellular plasma fraction; therefore, the authors hypothesized that the plasma fraction of stored packed erythrocytes promoted tumor progression.METHODS:Proliferation and migration of murine pancreatic cancer and control cells were determined in vitro in response to the plasma fraction from leukocyte and nonleukocyte‐reduced fresh versus stored packed erythrocytes. Last, an immunocompetent murine model was used to assess the effect of the plasma fraction of stored and processed packed erythrocytes on pancreatic cancer progression.RESULTS:Incubation of pancreatic cancer cells with the plasma fraction of packed erythrocytes increased proliferation and migration. Intravenous delivery of the acellular plasma fraction to mice with pancreatic cancer significantly increased the tumor weight in both leukocyte‐reduced and nonleukocyte‐reduced packed‐erythrocyte groups (P < .01), although tumor growth and morbidity were greatest in the nonleukocyte‐reduced group.CONCLUSIONS:The plasma fraction of stored packed erythrocytes promoted murine pancreatic cancer proliferation and migration in vitro and when administered intravenously, significantly augmented pancreatic cancer growth in immunocompetent mice. Cancer 2010. © 2010 American Cancer Society.
Ethnic differences in chronic health conditions after hematopoietic cell transplantation
Authors: Armenian Saro H. , Sun Can‐Lan , Teh Jennifer Berano , Arora Mukta , Baker K. Scott , Francisco Liton , Forman Stephen J. , Bhatia Smita 
Published: May 2010

AbstractBACKGROUND:Hispanics have a greater risk of early treatment failure after hematopoietic stem cell transplantation (HCT) compared with non‐Hispanic whites. However, long‐term morbidity among Hispanics has not been described.METHODS:Health‐related outcomes were examined in 159 Hispanic patients and 825 non‐Hispanic white patients who underwent HCT between 1974 and 1998 and survived a mean of 8.7 years. Patients completed a detailed questionnaire about sociodemographic factors and the occurrence of chronic health conditions.RESULTS:Exposure to total body irradiation (TBI) (odds ratio [OR], 1.94; 95% confidence interval [CI], 1.06‐3.56; P = .03), the presence of chronic graft versus host disease (GvHD) (OR, 3.99; 95% CI, 1.94‐8.24; P = .002), and health insurance coverage (OR, 3.46; 95% CI, 1.5‐8.01; P = .004), were associated significantly with severe/life‐threatening conditions. Compared with non‐Hispanic white patients, Hispanic patients were 53% less likely to report severe/life‐threatening conditions (OR, 0.47; 95% CI, 0.27‐0.83; P = .009) after adjusting for relevant clinical variables. This effect size was mitigated (OR, 0.56; 95%CI, 0.29‐1.08; P = .08) after adjusting for health insurance coverage.CONCLUSIONS:Hispanics were less likely to report severe/life‐threatening health conditions after HCT than non‐Hispanic whites—a difference that decreased in magnitude and significance after taking health insurance into consideration. Although the current results confirmed the role of TBI and chronic GvHD, in the current study, the role of a lack of health insurance coverage was identified as a mediator of the lower prevalence of self‐reported long‐term morbidity in Hispanics. Cancer 2010. © 2010 American Cancer Society.
Spinal cord sparing reirradiation with helical tomotherapy
Authors: Sterzing Florian , Hauswald Henrik , Uhl Matthias , Herm Hendrik , Wiener Andreas , Herfarth Klaus , Debus Jürgen , Krempien Robert 
Published: May 2010

AbstractBACKGROUND:The purpose of this study was to present planning, feasibility, toxicity, and outcome of helical tomotherapy for spinal cord‐sparing reirradiation of spinal metastases and tumors.METHODS:Thirty‐six patients with spinal metastases and tumors who had undergone previous radiotherapy were reirradiated with helical tomotherapy because of tumor progression, pain, or compromised stability. Mean spinal cord dose of previous radiotherapy was 36.3 grays (Gy) after a median time interval of 17.5 months. Mean prescribed dose of reirradiation was 34.8 Gy. Daily megavoltage computed tomography (CT) image guidance was performed to assure precise dose application.RESULTS:Mean beam time was 8.4 minutes; the dose maximum to the spinal cord at reirradiation could be limited to a 9.8‐Gy median dose (minimum, 5.2 Gy; maximum, 21.8 Gy). Significant pain relief from a median value of 7 on the visual analogue scale before therapy to a median value of 3 at 6 weeks after radiotherapy was achieved. One‐ and 2‐year local control was 76% and 63%; overall survival was 67% after 1 year and 58% after 2 years. One grade 2 skin toxicity and no grade 3 or higher toxicities were observed.CONCLUSIONS:Helical tomotherapy makes reirradiation of spinal metastases and excellent avoidance of the spinal cord possible and achieves good pain relief and local control. With a minimal distance of several millimeters between target volume and spinal cord, tailor‐made dose distributions with steep dose gradients around previously irradiated tissue are obtained and precisely applied with daily megavoltage CT‐based image guidance. Cancer 2010. © 2010 American Cancer Society.
Increased exposure to bacterial antigen RpL7/L12 in early stage colorectal cancer patients
Authors: Boleij Annemarie , Roelofs Rian , Schaeps Renée M. J. , Schülin Tanja , Glaser Philippe , Swinkels Dorine W. , Kato Ikuko , Tjalsma Harold 
Published: May 2010

AbstractBACKGROUND:Intestinal bacteria have long been implicated in colorectal cancer pathology, and many reports point to a close linkage between Streptococcus bovis biotype I (recently renamed Streptococcus gallolyticus) infections and tumors of the human colon. This work aims to investigate the humoral immune response to this bacterium during different stages of colorectal cancer.METHODS:The presence of serum antibodies against S. bovis antigen RpL7/L12, previously assigned as a potential diagnostic antigen, was evaluated in Dutch (n = 209) and American (n = 112) populations using a newly developed enzyme‐linked immunosorbent assay.RESULTS:The analyses consistently showed that an immune response against this bacterial antigen was increased in polyp patients and stage I/II colorectal cancer patients as compared with asymptomatic individuals. This was not paralleled by increased antibody production to endotoxin, an intrinsic cell wall component of the majority of intestinal bacteria, which implies that the humoral immune response against RpL7/L12 is not a general phenomenon induced by the loss of colonic barrier function. Notably, increased anti‐RpL7/L12 levels were not or were only mildly detected in late stage colorectal cancer patients having lymph node or distant metastasis.CONCLUSIONS:These findings are indicative of an increased exposure to antigen RpL7/L12 during early stages of colon carcinogenesis and suggest that intestinal bacteria such as S. bovis constitute a risk factor for the progression of premalignant lesions into early stage carcinomas. Clearly, the current findings emphasize the necessity for further studies on the possible etiologic relationship between intestinal bacteria and human colorectal cancer. Cancer 2010. © 2010 American Cancer Society.
Evaluation of neoadjuvant therapy and histopathologic response in primary, high‐grade retroperitoneal sarcomas using the sarcoma nomogram
Authors: Donahue Timothy R. , Kattan Michael W. , Nelson Scott D. , Tap William D. , Eilber Frederick R. , Eilber Fritz C. 
Published: May 2010

AbstractBACKGROUND:Patients with primary high‐grade retroperitoneal soft tissue sarcomas have a 5‐year disease‐specific survival (DSS) of <40%. The impact of neoadjuvant therapy on histopathologic response and DSS are unknown.METHODS:From 1987 to 2007, 55 patients with primary high‐grade retroperitoneal sarcoma received neoadjuvant therapy. All patients underwent surgical resection, and response was assessed histopathologically. Patients with ≥95% pathologic necrosis were classified as responders. Clinicopathologic variables were analyzed for association with DSS. Observed DSS was then compared with the Memorial Sloan‐Kettering Cancer Center Sarcoma Nomogram predicted DSS.RESULTS:The median tumor size was 15 cm, and the median follow‐up time for survivors was 68 months. The 5‐year DSS for all 55 patients was 47% and did not significantly differ from the 37% predicted by the sarcoma nomogram for such patients (P = .44). Fourteen (25%) of the patients had ≥95% pathologic necrosis and were defined as responders; 41 (75%) were nonresponders. The 5‐year DSS for responders was 83%. This was significantly better than the 5‐year DSS of 34% for nonresponders (P = .002) and the 39% predicted by the sarcoma nomogram for responders (P = .018). The 34% 5‐year DSS for nonresponders did not significantly differ from the 35% predicted by the sarcoma nomogram (P = .51).CONCLUSIONS:Neoadjuvant therapy was not associated with an overall improvement in DSS in patients with primary high‐grade retroperitoneal sarcoma compared with the sarcoma nomogram prediction. Histopathologic response to neoadjuvant therapy was associated with a significantly improved DSS compared with nonresponders and with the sarcoma nomogram prediction for such patients. Cancer 2010. © 2010 American Cancer Society.
Effect of the Structure of Cholesterol‐Based Tethered Bilayer Lipid Membranes on Ionophore Activity
Authors: Kendall James K. R. , Johnson Benjamin R. G. , Symonds Philip H. , Imperato Guiseppi , Bushby Richard J. , Gwyer James D. , van Berkel Cees , Evans Stephen D. , Jeuken Lars J. C. 
Published: May 2010

AbstractTethered bilayer lipid membranes (tBLM) are formed on 1) pure tether lipid triethyleneoxythiol cholesterol (EO3C) or on 2) mixed self‐assembled monolayers (SAMs) of EO3C and 6‐mercaptohexanol (6MH). While EO3C is required to form a tBLM with high resistivity, 6MH dilutes the cholesterol content in the lower leaflet of the bilayer forming ionic reservoirs required for submembrane hydration. Here we show that these ionic reservoirs are required for ion transport through gramicidin or valinomycin, most likely due to the thermodynamic requirements of ions to be solvated once transported through the membrane. Unexpectedly, electrochemical impedance spectroscopy (EIS) shows an increase of capacitance upon addition of gramicidin, while addition of valinomycin decreases the membrane resistance in the presence of K+ ions. We hypothesise that this is due to previously reported phase separation of EO3C and 6MH on the surface. This results in ionic reservoirs on the nanometre scale, which are not fully accounted for by the equivalent circuits used to describe the system.
Improvement of crystal quality of AlN grown on sapphire substrate by MOCVD
Authors: Lai Mu‐Jen , Chang Liann‐Be , Yuan Tzu‐Tao , Lin Ray‐Ming 
Published: May 2010

AbstractThe crystalline quality of aluminum nitride (AlN) epilayers grown on sapphire substrates by MOCVD was improved by increasing hydrogen flow rate during the high temperature growth process. The AlN epilayer exhibited a root mean square (rms) of roughness was 1.944 nm from the 2×2 µm2 size atomic force microscopy (AFM) images. Full widths at half maximum (FWHMs) of (002) and (102) rocking curves of triple‐axis high resolution X‐ray diffraction (HRXRD) measurements were as narrow as 28.8 arc sec and 868 arc sec, respectively. The optical transmittance spectra showed a sharp absorption edge at a wavelength of 200 nm and strong Fabry‐Perot (FP) oscillations. It is proposed that the improvement in crystalline quality is due to the surface in the low‐temperature aluminum nitride (LT‐AlN) buffer layer is promoted to be stable Al‐polarity by the conditions of increasing hydrogen flow rate and ramping up the growth temperature. Addtionally, the parasitic reactions are effectively suppressed by increasing the hydrogen flow rate during the growth process of high temperature. (© 2010 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)