bluuebunny/crossref_metadata_2025_split huggingface dataset:
Vacuum-assisted excision: a safe minimally invasive option for benign phyllodes tumor diagnosis and treatment—a systematic review and meta-analysis
Authors: Gil Maria Luísa Braga Vieira , Coelho Bertha Andrade , Couto Henrique Lima , Silva Henrique Moraes Salvador , Pessoa Eduardo Carvalho , Sharma Nisha , Mann Ritse , McIntosh Stuart A. , Diniz Paulo Henrique Costa , Cantidio Farley Soares , Gil Gabriel Oliveira Bernardes , Salvador Anna Dias , de Almeida Júnior Waldeir José , Avelar José Tadeu Campos , Laranjeira Cláudia Lourdes Soares , Silva Filho Agnaldo Lopes 
Published: May 2024

SynopsisThis is a systematic review and meta-analysis comparing surgical excision with percutaneous ultrasound-guided vacuum-assisted excision (US-VAE) for the treatment of benign phyllodes tumor (PT) using local recurrence (LR) as the endpoint.ObjectiveTo determine the frequency of local recurrence (LR) of benign phyllodes tumor (PT) after ultrasound-guided vacuum-assisted excision (US-VAE) compared to the frequency of LR after surgical excision.MethodA systematic review and meta-analysis [following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) standard] was conducted by comparing LR in women older than 18 years treated for benign PT by US-VAE compared with local surgical excision with at least 12 months of follow-up. Studies were retrieved from PubMed, Scopus, Web of Science, and Embase. The pooled effect measure used was the odds ratio (OR) of recurrence.ResultsFive comparative prospective or retrospective observational studies published between January 1, 1992, and January 10, 2022, comparing surgical excision with percutaneous US-VAE for LR of benign PT met the selection criteria. Four were retrospective observational cohorts, and one was a prospective observational cohort. A total of 778 women were followed up. Of them, 439 (56.4%) underwent local surgical excision, and 339 (43.6%) patients had US-VAE. The median age of patients in the five studies ranged from 33.7 to 39 years; the median size ranged from 1.5 cm to 3.0 cm, and the median follow-up ranged from 12 months to 46.6 months. The needle gauge ranged from 7G to 11G. LR rates were not statically significant between US-VAE and surgical excision (41 of 339 versus 34 of 439; OR 1.3; p = 0.29).ConclusionThis meta-analysis suggests that using US-VAE for the removal of benign PT does not increase local regional recurrence and is a safe minimally invasive therapeutic option.Systematic review registrationhttps://www.crd.york.ac.uk/prospero/, identifier CRD42022309782.
Post-COVID-19 headache- NDPH phenotype: a systematic review of case reports
Authors: Dhiman Neetu Rani , Joshi Deepika , Singh Royana , Gyanpuri vyom , Kumar Anand 
Published: May 2024

Background and objectivesPost-acute COVID-19 syndrome or “long COVID” affects patients even after the recovery from Covid infection in various ways. Persistent headache or New Daily Persistent Headache (NDPH) is one of such symptoms. In this review, we will discuss about the case-reports of post covid-19 headache- NDPH phenotype both after and in the course of COVID-19 infection.MethodsCase reports/studies talked about patients having NDPH around the disease either immediately or late post COVID were included. Data was taken from the source and synthesised on a qualitative basis.ResultsLiterature search showed 3,538 articles, out of which 12 were screened as per the eligibility criteria and finally, 4 case reports on NDPH and Covid-19 were chosen for analysis from the database and by human search. All case reports justify the criteria for acceptability in quality for this systematic review.ConclusionNDPH in and around Covid 19 infection is something that is currently an ingenious debated topic in the scientific community. More case studies should be written and published on the same subject so that a large systematic review could be conducted.Trial Registration InformationThe review is registered in Prospero with no. Identifier (CRD42022354912).Systematic Review Registrationhttps://www.crd.york.ac.uk/, PROSPERO (CRD42022354912).
Assessing the time variability of GIEMS-2 satellite-derived surface water extent over 30 years
Authors: Bernard Juliette , Prigent Catherine , Jimenez Carlos , Frappart Frédéric , Normandin Cassandra , Zeiger Pierre , Xi Yi , Peng Shushi 
Published: May 2024

Inland waters, especially wetlands, play a crucial role in biodiversity, water resources and climate, and contribute significantly to global methane emissions. This study investigates the seasonal and inter-annual variability of the 0.25° × 0.25° surface water extent (SWE) from the Global Inundation Extent from Multi-Satellites (GIEMS-2) extended to a 30-year time series (1992–2020). Comparison with MODIS-derived SWE, CYGNSS-derived SWE and the Global Lakes and Wetlands Database (GLWD) shows consistent spatial patterns globally and over 10 different basins, although there are discrepancies in extent, partly due to different resolutions of the initial satellite observations. Strong cross-correlation (>0.8) in seasonal variability is observed when comparing GIEMS-2 with MODIS, CYGNSS and river discharge in most of the basins studied. Encouraging similarities were found in the inter-annual variability in most basins (cross-correlation >0.6) between GIEMS-2 and MODIS over 20 years, and between GIEMS-2 and river discharge over long time series, including over the Amazon and the Congo basins. These results highlight the reliability of GIEMS-2 in detecting changes in SWE in different environments, especially under dense vegetation, making it a valuable resource for calibrating hydrological models and studying global methane emissions.
Dual career through the eyes of university student-athletes in the Republic of Kosovo
Authors: Gjaka Masar , Feka Kaltrina , Tessitore Antonio , Thomas Abbey , Capranica Laura 
Published: May 2024

IntroductionThe successful combination of a sports career and education, known as the dual career, requires cooperation and a multi-dimensional approach. Although extensive research has been conducted on dual career programs and services in developed countries, there is limited information available on the dual-career phenomenon in developing countries. This study aimed to explore the dual career experiences of university student-athletes in the Republic of Kosovo.Materials and methodsA 30-item online survey was distributed to student-athletes, addressing various aspects of the dual career. A total of 121 student-athletes (males: 63.6%; females: 36.4%) voluntarily participated in the survey.ResultsThese student-athletes represented 13 different sports, with 102 (84.3%) participating in team and 19 (15.7%) in individual sports. Between individual and team sports no significant differences were found regarding university and sports engagement, and the time required to travel from the university to the training venue, whereas a significant difference (p = 0.019) emerged for the time needed to travel from home to the training venue. Significant differences (p &lt; 0.05) were found between university majors in terms of sports engagement. The present findings highlight a lack of familiarity with dual career programs among student-athletes (89.3%) and the need for dual-career policies at the university (16.5%), sport (9.9%), and national (13.2%) levels. Student-athletes faced various challenges, mainly related to limited leisure time (62.8%), academic overload (60.3%), frequent absence from classes (59.6%), and financial uncertainty (35.5%). Recommended improvements included increased financial support (66.1%), the availability of sports facilities at or near the university (48.8%), greater educational flexibility (26.4%), tutoring services at the university (25.6%), and sports clubs (19%) levels, as well as improved communication regarding existing initiatives and legal aspects (53.7% and 47.1%, respectively). The study also identified parents (98.3%), coaches (86%), and siblings (60.3%) as important sources of support for student-athletes at personal, sports, and university levels.ConclusionsIn conclusion, to enhance the potential of future student-athletes in the Republic of Kosovo, relevant stakeholders in sports and higher education should collaborate closely and implement programs and services based on international best practices for dual-career support.
Exoskeleton-assisted training to enhance lower limb motor recovery in subacute stroke: does timing matter? A pilot randomized trial
Authors: Schröder Jonas , Yperzeele Laetitia , Embrechts Elissa , Loureiro-Chaves Renata , Hallemans Ann , Lafosse Christophe , Truijen Steven , Kwakkel Gert , Saeys Wim 
Published: May 2024

BackgroundLower limb motor recovery, including abnormal muscle synergies, occurs mainly within the first 5–8 weeks after a stroke. This suggests the importance of delivering impairment-focused therapies, such as therapeutic robots that promote symmetric gait, during this time-sensitive period, following the principle of “the earlier, the better.”ObjectiveFirst, to compare early robotic training (ERT) with usual care (UC) against UC alone on restoring intralimb muscle synergies and interlimb symmetry during functional tasks; Second, to investigate whether ERT is superior to delayed robotic training (DRT) starting after the proposed time-sensitive period.MethodsThis observer-blinded, randomized pilot trial with crossover design involved 19 nonambulatory adults included within 14 days poststroke. Those allocated to ERT (N = 10) received immediately 4 weeks of training (16 sessions, 4× /week) with the Ekso GT® above UC and were compared with the DRT group (N = 9) who received UC alone at this point. Thereafter a 3-week UC period followed to investigate sustainability of ERT and the interventional roles were exchanged; at about week 8 poststroke DRT subjects started the same experimental robotic protocol and ERT subjects continued UC as controls. Outcomes included changes in Fugl-Meyer lower extremity scores (FM-LE) reflecting muscle synergies, weight-bearing asymmetry (WBA), and dynamic control asymmetry (DCA) during quiet standing. Functional ambulation category (FAC) was used to classify walking independence (cut-off ≥4).ResultsA trend toward earlier reacquisition of walking independence favoring ERT with UC over UC was not accompanied by differences in FM-LE, WBA, or DCA (first objective). Thereafter, DRT with UC did not yield any significant changes relative to UC, such that no between-group differences were found favoring restorative effects of ERT over DRT (second objective).ConclusionThis pilot trial shows the feasibility of investigating a wearable exoskeleton as an adjunct therapy in subacute stroke. Nevertheless, our preliminary findings suggest that motor recovery of lower limb muscle synergies was not enhanced by 4 weeks of robotic training to reduce compensations with the less-affected side, irrespective of the timing of application.Trial registrationClinicalTrials.gov, identifier: NCT03727919.
Challenges of Robust RNAi-Mediated Gene Silencing in Aedes Mosquitoes
Authors: Figueiredo Prates Lucas Henrique , Fiebig Jakob , Schlosser Henrik , Liapi Eleni , Rehling Tanja , Lutrat Célia , Bouyer Jeremy , Sun Qiang , Wen Han , Xi Zhiyong , Schetelig Marc F. , Häcker Irina 
Published: May 2024

In this study, we report the complexities and challenges associated with achieving robust RNA interference (RNAi)-mediated gene knockdown in the mosquitoes Aedes aegypti and Aedes albopictus, a pivotal approach for genetic analysis and vector control. Despite RNAi’s potential for species-specific gene targeting, our independent efforts to establish oral delivery of RNAi for identifying genes critical for mosquito development and fitness encountered significant challenges, failing to reproduce previously reported potent RNAi effects. We independently evaluated a range of RNAi-inducing molecules (siRNAs, shRNAs, and dsRNAs) and administration methods (oral delivery, immersion, and microinjection) in three different laboratories. We also tested various mosquito strains and utilized microorganisms for RNA delivery. Our results reveal a pronounced inconsistency in RNAi efficacy, characterized by minimal effects on larval survival and gene expression levels in most instances despite strong published effects for the tested targets. One or multiple factors, including RNase activity in the gut, the cellular internalization and processing of RNA molecules, and the systemic dissemination of the RNAi signal, could be involved in this variability, all of which are barely understood in mosquitoes. The challenges identified in this study highlight the necessity for additional research into the underlying mechanisms of mosquito RNAi to develop more robust RNAi-based methodologies. Our findings emphasize the intricacies of RNAi application in mosquitoes, which present a substantial barrier to its utilization in genetic control strategies.
The Dynamics of Vegetation Structure, Composition and Carbon Stock in Peatland Ecosystem of Old Secondary Forest in Riau and South Sumatra Provinces
Authors: Dharmawan I Wayan Susi , Heriyanto Nur M. , Garsetiasih Raden , Kwatrina Rozza Tri , Sawitri Reny , Denny  , Setyawati Titiek , Pratiwi  , Narendra Budi Hadi , Siregar Chairil Anwar , Abywijaya Ilham Kurnia 
Published: May 2024

Lowland tropical rainforests provide an abundance of biodiversity as well as dynamic and stable ecosystems. These forests include tropical peat forests in various locations and forest types that have vegetation structure and composition characteristics, and carbon stocks that still need to be explored more deeply. Research on the structure and the composition of the vegetation and carbon stock in the old secondary peat forest was carried out in the protected areas of Bukit Batu, Riau Province, and Muara Merang, South Sumatra Province. Based on a 1-hectare permanent plot established in Bukit Batu and Muara Merang, 25 subplots of 20 m by 20 m were established in each location for measurement purposes. The results showed that Bukit Batu and Muara Merang had 42 and 36 species belonging to 26 and 20 families, respectively. Bukit Batu had a species diversity index (H’) of 2.93, and the dominant tree species were Palaquium xanthochymum with an importance value index (IVI) = 66.27%, Eugenia sp. (IVI = 32.76%), and Litsea sp. (IVI = 18.39%). The Muara Merang location had a species diversity index (H’) of 2.82, and the dominant tree species were Eugenia sp. (IVI = 60.88%), Alseodaphne insignis (IVI = 26.34%), and Adenanthera pavonina (IVI = 22.11%). In Bukit Batu, forest stands with a diameter of ≥10 cm contained a biomass of 178.10 tonnes/ha and carbon stock of 83.70 tonnes C/ha, which is equal to 307.20 tonnes CO2/ha. Meanwhile, in Muara Merang, it was 190.41 tonnes/ha and 89.49 tonnes C/ha, which is equal to 328.44 tonnes CO2/ha. This research, especially that in Bukit Batu, Riau Province, enriches the data and information available to date and is very useful in supporting restoration practices in Riau Province’s Giam Siak Kecil Biosphere Reserve, which was designated by UNESCO as part of the Man and Biosphere Program.
Comportamento do índice tornozelo-braquial e dos parâmetros centrais em um ambulatório de cardiologia
Authors: Barbosa Filho Antônio Carlos de Almeida , Guedes Andressa de Melo Cavalcanti , Tenório Emanuelle Costa Pereira Tavares , Souza Fransciédna de Oliveira , Silva Érica de Andrade Alves da , Paiva Annelise Machado Gomes de 
Published: May 2024

Introdução: Os eventos cardiovasculares exibem um crescimento exponencial nas últimas décadas e persistem como a principal causa de mortalidade mundial. O exame do índice tornozelo-braquial (ITB) que auxilia no diagnóstico da doença arterial obstrutiva periférica (DAOP) dos membros inferiores, e os parâmetros centrais (PCs), úteis para o diagnóstico de rigidez arterial, são preditores de eventos cardiovasculares e de mortalidade. Objetivo: Observar o comportamento do índice tornozelo-braquial e dos parâmetros centrais em um ambulatório de Cardiologia em Maceió/Alagoas. Metodologia: Estudo observacional transversal descritivo, realizado com pacientes atendidos em um ambulatório de cardiologia em Maceió/Alagoas. Foram avaliados dados demográficos, clínicos e antropométricos, além da verificação do ITB com o esfigmomanômetro oscilométrico automático. A obtenção dos PCs, como a pressão sistólica central (PSc), velocidade da onda de pulso (VOP) e o Augmentation Index (Alx), foi possível através do equipamento Mobil-O-Graph. Resultados: Foram incluídos 114 pacientes, sendo a maioria do sexo feminino 65,79% (n=75), com média de idade de 54,18 ± 13,67 anos. Cerca de 81,57% (n=93) da amostra apresentou DAOP pelo ITB, mas apenas uma minoria expressou alguma anormalidade em um dos PCs colhidos. A VOP estava alterada em 25,71% (n=27) dos participantes, destes, apenas 7,4% (n=2) possuíam DAOP. Não houve associação entre VOP e DAOP e entre ITB e outros PCs, mesmo após ajuste para sexo. Discussão: Há certa divergência na literatura quanto à associação de PCs, principalmente VOP, com DAOP. Todavia, pode-se dizer que o ITB é um método de baixo custo, fácil acesso e útil no diagnóstico precoce da DAOP, importante para redução da morbimortalidade. Conclusão: As variáveis dos PCs não foram preditivas para o diagnóstico de DAOP e não apresentaram correlação com o ITB, contudo, novos estudos podem elucidar mais seguramente uma possível correlação entre ITB e PCs.
As alterações celulares e imunológicas e suas implicações no Transtorno de Déficit de Atenção e Hiperatividade (TDAH)
Authors: Barbosa Janaína de Alencar , Sobrinho Caroline Magalhães Tenório Rocha , Feitosa Junior Marcilio Moreira , Figueira João Rubens Ribeiro , Brandão Júlia Tenório , Moura Aline Coelho , Ferreira Brunna Karolyne Aguiar , Borges Isabela Caracas Machado 
Published: May 2024

O Transtorno do Déficit de Atenção e Hiperatividade (TDAH) é uma condição neuropsiquiátrica prevalente em crianças, adolescentes e adultos, com impactos significativos em diversos aspectos da vida. Estudos recentes exploram possíveis vínculos entre o sistema imunológico e o TDAH, concentrando-se nas citocinas pró-inflamatórias. O artigo irá abordar as alterações celulares e imunológicas com o TDAH de forma concisa baseada nas interleucinas, no Eixo hipotalâmico-pituitário-adrenal (HPA) e o cortisol, no Eixo intestino-cérebro e a obesidade, finalizando com Neurotrofinas, Estresse oxidativo e Micróglia. Em julho de 2023 foi realizada uma busca na base de dados via PubMed, Lilacs e Scielo, com o uso dos descritores ‘’ADHD’’ and ‘’Inflammatory’’ and “Imunne” e aplicado o filtro dos últimos 8 anos. Foram encontrados 216 artigos e após aplicar os critérios de inclusão e exclusão, 10 foram selecionados para o estudo. Embora as evidências sugiram uma associação potencial entre as interleucinas especialmente a interleucina-6, alguns eixos como o eixo HPA e o eixo intestino-cérebro, além de associar o cortisol, neurotrofinas, estresse oxidativo e células da micróglia com o transtorno abordado, é importante destacar que a problemática em destaque é multifatorial e envolve uma complexa interação de fatores genéticos, ambientais e neurobiológicos.
ABORDAGEM AO PACIENTE COM TRAUMA TORÁCICO: LESÕES E TRATAMENTOS EMERGENCIAIS
Authors: Oliveira Amanda Silva de , Valerio Fabricio Ricardo , Neto Antônio Carlos da Silva Araújo , Dias Aguinaldo Pereira , Ferreira Letícia Beatriz Rodrigues , Guidas Annielly Rodrigues , Campos Adria Melissa Silva , Carmo Alaíne Sttefany Martins do , Biallowons Lauren Lee Schuster , Galvão Nikolas Sivini Borges , Aurélio Salete Martens , Silva Aline Passos da 
Published: May 2024

Uma abordagem eficaz ao paciente com trauma torácico é crucial para garantir uma gestão adequada das lesões e o tratamento emergencial. O trauma torácico pode resultar em uma variedade de lesões, desde fraturas de costelas até lacerações pulmonares e contusões cardíacas, exigindo uma avaliação rápida e precisa para determinar a gravidade e iniciar intervenções terapêuticas imediatas. Objetivos: Revisar as principais lesões associadas ao trauma torácico e os tratamentos emergenciais correspondentes, visando melhorar a compreensão e a prática clínica na abordagem desses pacientes. Materiais e Métodos: Para a obtenção de dados, foram empregados os recursos dos seguintes repositórios: Scientific Electronic Library Online (SCIELO), PubMed e Literatura Latino-Americana do Caribe em Ciências da Saúde (LILACS). Uma variedade de fontes, incluindo artigos científicos, monografias e periódicos, foi examinada para extrair informações pertinentes sobre o assunto. Resultados e Discussões: Destaca-se a importância da avaliação rápida e precisa do paciente com trauma torácico para identificar lesões potencialmente graves, como pneumotórax, hemotórax, lesões cardíacas e contusões pulmonares. A discussão enfatiza a necessidade de intervenções emergenciais imediatas, como drenagem torácica, ressuscitação volêmica e suporte ventilatório, para melhorar os desfechos clínicos e reduzir a morbimortalidade associada ao trauma torácico. Além disso, são abordadas considerações adicionais, como a prevenção de complicações, o manejo da dor e a transferência adequada para centros especializados, quando necessário. Conclusão: Em conclusão, uma abordagem sistemática e ágil ao paciente com trauma torácico é essencial para identificar e tratar lesões potencialmente graves de maneira eficaz. A intervenção precoce, incluindo o reconhecimento e a correção de alterações fisiológicas, juntamente com o suporte adequado, pode melhorar significativamente os desfechos clínicos. No entanto, são necessários mais pesquisas e estudos para aprimorar ainda mais os protocolos de manejo e melhorar os resultados para pacientes com trauma torácico.
Risk Factors for Coronary Artery Diseases: A Study among Patients with Atherosclerosis in Jalal-abad
Authors: - Meena Gyawali , - Ravi Roshan Khadka , - Saranya Sureshbabu , - Mamutov Altynbek Djunusmamatovich 
Published: May 2024

Background: Cardiovascular Disease (CVD) became threat to the world-wide populations. In our day-to-day life my people are losing their life just because of Cardiovascular problems. Cardiovascular diseases (CVDs) are the leading cause of death globally, taking an estimated 17.9 million lives each year [1]. It causes the most significant rate of mortality among the population. Unhealthy lifestyle and some other factors have been found the leading causes for death due to cardiovascular disease in the Kyrgyzstan. This research is done to find out the main causes of coronary artery disease (CAD) among the population. The Main objective of the research is to study the risk factors coronary artery diseases and amount of the effects each factor contributes towards the disease.
Method: The cross-sectional survey was conducted in the cardiology hospital located in Jalalabad, Kyrgystan, during the time period of one and half month. The hospital provided a proportionate amount of the total sample size (106). Using a systematic sampling procedure, study participants were chosen. A p-value of less than 0.05 was deemed statistically noteworthy.
Result: Totally 106 patients’ data has been collected. Smoking, drinking alcohol, family history, diabetes, hypertension and hypercholesterolemia are the six risk factors. Among these risk factors, hypertension (30.3%) was major cause for coronary diseases. Hypercholesterolemia (26.8%) comes the second major risk factor. Family history of heart disease (12.7%), Diabetes (11.3%), smoking (10.6%) and drinking alcohol (8.5%) are the factors in the next four places.
Conclusion: The major risk factor was found to be the Hypertension and Hyperlipidemia. Along with these, smoking, drinking alcohol, diabetes obesity and family history also contributes in causing the CAD. Lifestyle and food habits modifications are must advisable to prevent the CAD.