bluuebunny/crossref_metadata_2025_split huggingface dataset:
PROBLEMS OF PROFESSIONAL ADAPTATION OF A YOUNG TEACHER IN MODERN CONDITIONS OF THE EDUCATIONAL SPACE (BY THE EXAMPLE OF THE SVERDLOVSK REGION)
Authors: ШАЛАГИНА Е.В. , ШИХОВА О.Н. 
Published: May 2024

В условиях кадрового дефицита в уральском регионе поднимается тема актуальных вопросов функционирования и развития образовательного пространства в части за- крепления молодых специалистов в педагогической среде, их адаптации в учитель- ской профессии. Целью статьи выступает анализ жизненных планов, профессионального самочувствия, оценка дефицитов и ресурсов молодых педагогов. Авторы обращаются к ре- зультатам оригинального прикладного исследования, разработчиками которого они явля- ются. В рамках реализованных в данном проекте качественной и количественной исследо- вательских стратегий представляются полученные данные, которые описывают отношение группы молодых учителей к различным механизмам организации адаптационных процес- сов в современной образовательной организации, их оценку эффективности данных усло- вий вхождения в профессию, а также потребности и ориентации этой социальной группы на альтернативные формы и методы построения систем адаптации в образовании как про- фессиональной среде.
In conditions of human resources(personnel) shortage in the Ural region, the topic of issues of the functioning of the educational space is raised in terms of keeping young specialists in the teaching environment, their adaptation in the teaching profession. The purpose of the article is analyze life plans, professional well-being, and assess the deficits and resources of young teachers. The authors refer to the results of original applied research of which they are the developers. The authors realized qualitative and quantitative research strategy. They describe the attitude of a group of young teachers to various mechanisms for organizing adaptation processes in a modern educational organization, their assessment of the effectiveness of these conditions for entering the profession. Also the authors reseachthe needs and orientations of this social group towards alternative forms and methods of building adaptation systems in education as a professional environment.
Crizotinib inhibits the metabolism of tramadol by non-competitive suppressing the activities of CYP2D1 and CYP3A2
Authors: Gao Nanyong , Xu Xiaoyu , Ye Feng , Li Xin-yue , Lin Chengqi , Shen Xiu-wei , Qian Jianchang 
Published: May 2024

Objectives
To investigate the interaction between tramadol and representative tyrosine kinase inhibitors, and to study the inhibition mode of drug-interaction.

Methods
Liver microsomal catalyzing assay was developed. Sprague-Dawley rats were administrated tramadol with or without selected tyrosine kinase inhibitors. Samples were prepared and ultra-performance liquid chromatography–tandem mass spectrometry (UPLC-MS/MS) was used for analysis. Besides, liver, kidney, and small intestine were collected and morphology was examined by hematoxyline-eosin (H&E) staining. Meanwhile, liver microsomes were prepared and carbon monoxide differential ultraviolet radiation (UV) spectrophotometric quantification was performed.

Results
Among the screened inhibitors, crizotinib takes the highest potency in suppressing the metabolism of tramadol in rat/human liver microsome, following non-competitive inhibitory mechanism. In vivo, when crizotinib was co-administered, the AUC value of tramadol increased compared with the control group. Besides, no obvious pathological changes were observed, including cell morphology, size, arrangement, nuclear morphology with the levels of alanine transaminase (ALT) and aspartate transaminase (AST) increased after multiple administration of crizotinib. Meanwhile, the activities of CYP2D1 and CYP3A2 as well as the total cytochrome P450 abundance were found to be decreased in rat liver of combinational group.

Conclusions
Crizotinib can inhibit the metabolism of tramadol. Therefore, this recipe should be vigilant to prevent adverse reactions.
Evaluating the progress of alcohol policies in Burundi against the WHO ‘best buy’ interventions: implications for public health.
Authors: Haragirimana Egide , Mitchell Gemma , Uny Isabelle 
Published: May 2024

Introduction: Alcohol use is a major global health risk, with Global South countries experiencing greater harm per litre of alcohol consumed than those in the Global North. In Burundi, a country with a low-income economy, 16.6% of people aged 15 and above binge drink, and over 30% of women drink during pregnancy. This paper examines current alcohol policies in Burundi, how well they match the WHO ‘best buy’ policy options, and stakeholder views on their implementation.

Methods: We searched for policy documents via online searches, visits to government offices, and snowball sampling from contact with key stakeholders. Semi-structured interviews were conducted with ten stakeholders. The WHO-European Action Plan to Reduce the Harmful Use of Alcohol (EAPA) tool was used to analyse the extent to which Burundi has adopted recommended policy standards. Interviews were thematically analysed using NVivo software.

Results: Only nine of the 34 WHO-EAPA indicators are addressed, seven out of 34 indicators are mentioned with no clear actions, and 18 are not addressed in the eight policy documents that met our inclusion criteria. The large proportion of indicators absent from Burundi policy relate to availability, pricing and taxation, drinking-driving, taxation, and marketing. An absence of legislation to support existing policies, industry interference, corruption, and cultural norms around alcohol were identified as key barriers to implementation.

Conclusions: Burundi should enact laws to support existing policies and design regulations targeting marketing and advertising. Government and civil society coalitions should report and address any alcohol industry influence in policymaking and implementation.
Comparative Impact of Formal and Informal Microcredits on Poverty Alleviation in the Haor Region of Bangladesh: A Socioeconomic Analysis
Authors: Islam Md. Nazrul , Islam Sabina , Ornob Md. Shafayet Shahed 
Published: May 2024

The study aims to make a comparative study of microcredits (formal and informal) in terms of interest rate, instalment types, payment, volume, purposes, users and impact on poverty alleviation in the economic lagging area of Bangladesh. In conducting the study, we used clusters sampling technique while the study area was divided into 23 clusters and size of respondents were determined using systematic probability proportionate to size and the UNICEF pencil-spin method was used to select the households randomly and finally a total 2340 households were surveyed with a semi-structured questionnaire where 780 households were treatment group who were not users of microcredit but eligible. The collected data were analyzed using a Z-test and factor analysis mainly. The findings showed that there is a significant difference between formal and informal credits in respect of interest rate, cost, instalments, number, volume, duration, and collateral. The borrowers preferred informal sources over formal sources and the study suggested redesigning the formal sources considering the socioeconomic condition of the Haor people. The study originally identified the socioeconomic characteristics of both formal and informal microcredits in Bangladesh. The study will directly help to achieve SDG-1(no poverty) and SDG -17(sustainable finance).
Optimizing Guava Crop Yield and Quality through Various Regulation Methods
Authors: Rani Kumari Vibha , Kumar Manoj , Umesh Umesh Narayan , Sinha Jyoti , Kumari Seema 
Published: May 2024

Guava is an important fruit crop grown in subtropical region of India. It belongs to family Myrtaceae. The demand for this fruit is increasing day by day due to its good nutritional value and its different processed products. It is also known as poor man’s apple. An on-farm trial was conducted in guava orchards of different farmers field in different villages of Nalanda district during 2020-2021 and 2021-2022 consecutively. The main objective of this trail is to force the tree for rest during undesirable season crop and shift that crop to desirable season with quality fruit by regulating the crop. The main theme of this is to enhance yield and quality of fruit by suppressing rainy season crop and promoting winter season crop by pruning or spray of 10 percent urea as compared to farmer’s practice. The practice of farmers is usually taking major crop in rainy season fruit with poor quality, insipid taste with poor shelf life in most part of the Bihar. For crop regulation different methods such as withholding irrigation, pruning of current season shoots in different ways, spraying of different chemicals is used according to different agro climatic regions. In our trial we have done 50 percent pruning of current season shoots in the month of April in ten trees and spray of 10 percent urea solution on ten trees at the time of blossoming at different locations. We got the best result in pruning of 50 percent current season shoot with 27.69 kg/plant yield with 11.40 Brix T.S.S during 2020-2021 and 28.06 kg/plant with 11.60 Brix T.S.S during 2021-2022.The best treatment is pruning of 50 percent current season shoots in the month of April is best for getting higher yield and getting maximum quality fruit for guava grower . Although the T.S.S. of fruits harvested in case of urea spray during winter season is at par with pruning of current season shoot.
Cellular Ceramics in Combustion Environments
Authors: Füssel Alexander , Böttge Daniela , Adler Jörg , Marschallek Felix , Michaelis Alexander 
Published: July 2011

AbstractCellular materials have become increasingly interesting for applications in combustion environments. Improvements like high power efficiency and low emissions are the main targets of technological development in combustion processes. However, despite scientific and technical success in developing new or improved burner concepts over recent years, a lot of problems remain to be solved in the field of materials science: due to the high power density of the burners the materials are subjected to high loads in terms of thermal shock, temperature and corrosion, especially in so‐called porous burner technology. This article shows some examples of research and development strategies and results in developing improved cellular ceramics.
New Approach for the Application of Functional Ceramic Material in Carbon Bonded Doloma Refractories to Reduce Emissions
Authors: Stein Volker , Aneziris Christos G. , Guéguen Erwan 
Published: July 2011

AbstractDoloma carbon bricks with graphite contents of approximately 2 wt% are widely used in the production of stainless steels in argon oxygen decarburisation (AOD) or in vacuum oxygen decarburisation (VOD) vessels as lining material. The application of doloma refractories is connected with metallurgical benefits such as high oxidic stability of its oxides, and the ability to bond sulphur from the hot metal. The production and application of carbon bonded refractories is linked with environmental harmful emissions in the broadest sense. Amongst the aspect of environmental friendly refractory systems this work has observed and shown the interaction of functional ceramic material TiO2 with the organic binder system. In the centre of this work is the aspect of increased residual carbon content of the binder resin due to TiO2 addition. The increased residual carbon content of the binder resin connected with improved mechanical, physical and thermomechanical properties due to sub‐micro scaled TiO2 addition offers the feasibility to reduce the total carbon content without downgrading the brick properties. This aspect has not been observed yet and is of high interest with respect to reduced emissions and environmental friendly refractories. Previous works have investigated the influence of TiO2 on other carbon bonded refractory systems such as alumina carbon and magnesia carbon. As illustrated in this work and previous work, TiO2 is working completely different in the Doloma Carbon system from other systems.
Martensitic Phase Transformation in TRIP‐Steel/Mg‐PSZ Honeycomb Composite Materials on Mechanical Load
Authors: Weigelt Christian , Aneziris Christos G. , Berek Harry , Ehinger David , Martin Ulrich 
Published: July 2011

AbstractComposite materials have been in focus of scientific studies since decades. Metal‐matrix composites have received extensive attention in the last years. The combination of a metastable austenitic TRIP‐steel with magnesia partially stabilized zirconia is presented in this study. The stress induced martensitic phase transformation in both components leads to advantageous mechanical behavior. Raised compression strength as well as increased specific energy absorption on plastic deformation offers a range of structural and crash‐absorption applications. Samples with zirconia additions are reinforced by volume increase during tetragonal‐monoclinic phase transformation at compressive strains below 35%. The microstructure and phase evolution of partially stabilized zirconia as well as steel has been investigated by EBSD with purpose to correlate mechanical properties with phase evolution.
Molecular model of human heparanase with proposed binding mode of a heparan sulfate oligosaccharide and catalytic amino acids
Authors: Sapay Nicolas , Cabannes Éric , Petitou Maurice , Imberty Anne 
Published: July 2011

AbstractHeparan sulfate is abundantly present in the extracellular matrix. As other glycosaminoglycans, it is synthesized in the Golgi apparatus and then exposed on the cell surface. The glucuronidase activity of human heparanase plays a major role in the structural remodeling of the extracellular matrix, which underlies cell migration, hence tumor invasion. Heparanase is therefore a major target for anti‐cancer treatment. Several inhibitors of its enzymatic activity have been synthesized. However, their design is limited by the absence of experimental structure of the protein. Homology modeling is proposed based on the structure of the endoxylanase from Penicillium simplicissimum co‐crystallized with a series of xylan oligosaccharide. The new heparanase model is consistent with the few experimental data suited for the validation of such work. Furthermore, the presence of natural substrates in the template structure allowed us to propose a binding model for a hydrolyzed heparin sulfate pentasaccharide. Several lysine residues have been identified to play a key role in binding to the anionic polysaccharide substrate. In addition, two phenylalanine residues are also potentially important for the interaction with the substrate. The enzymatic mechanism investigated in the light of this new model allows for the proposal of several amino acids that can influence the protonation state of the nucleophile and the proton donor. © 2011 Wiley Periodicals, Inc. Biopolymers 97: 21–34, 2012.
An easy and effective demonstration of enzyme stereospecificity and equilibrium thermodynamics
Authors: Herdman Chelsea , Dickman Michael 
Published: July 2011

AbstractEnzyme stereospecificity and equilibrium thermodynamics can be demonstrated using the coupling of two amino acid derivatives by Thermoase C160. This protease will catalyze peptide bond formation between Z‐L‐AspOH and L‐PheOMe to form the Aspartame precursor Z‐L‐Asp‐L‐PheOMe. Reaction completion manifests itself by precipitation of the product. As the product has almost zero solubility, the equilibrium favors condensation and thus a normally hydrolytic enzyme catalyzes the opposite reaction. Neither Z‐D‐AspOH with L‐PheOMe nor Z‐L‐AspOH with D‐PheOMe produces any visible product. Biochemistry and Molecular Biology Education, 2011
The use of gadolinium in patients with contrast allergy or renal failure requiring coronary angiography, coronary intervention, or vascular procedure
Authors: Saleh Layth , Juneman Elizabeth , Reza Movahed Mohammad 
Published: July 2011

AbstractCoronary artery angiography remains an important procedure for the assessment of coronary arteries. It requires injection of iodinated contrast for the opacification of coronary arteries. Severe allergy to iodine contrast and renal insufficiency are two main problems with iodine‐based contrast media. Gadolinium (Gd) has different chemical structure with no cross reactivity with iodine‐based contrast media in patients with iodine allergy. The use of Gd is commonly used in contrast‐enhanced magnetic resonance imaging for image enhancement, making it a potential alternative in patients in whom iodine is contraindicated. The aim of this manuscript is to review the available literature on the use of Gd in patients with contraindication to iodine contrast due to allergy or in patients with severe renal failure requiring coronary or vascular procedures. © 2011 Wiley‐Liss, Inc.
Radial artery perforation after coronary intervention: Is there a role for covered coronary stent?
Authors: Al‐Sekaiti Rashid , Ali Mehar , Sallam Mansour 
Published: July 2011

AbstractWe report a case of right radial artery perforation observed after successful stenting of left anterior descending artery through right radial access. This was noticed immediately after completion of the procedure, when the patient described right forearm pain and we noticed swelling of the right forearm. She was treated by a prolonged guiding catheter positioning proximal to the perforated segment, external compression by sphygmomanometer cuff followed by prolonged balloon inflation across the perforation. All these measures failed to stop the bleeding. Complete reconstruction of the perforation was achieved by PTFE covered coronary stent. To our knowledge, this is the first case to be managed utilizing this approach. © 2011 Wiley‐Liss, Inc.
Percutaneous closure of a large iatrogenic fistula between the inferior vena cava and the pulmonary vein in a child
Authors: Saliba Zakhia , El‐Rassi Issam , Smayra Tarek 
Published: July 2011

AbstractWe hereby describe a complex late postoperative veno‐venous fistula in a child, successfully treated by an interventional percutaneous procedure. It is a unique complication of diaphragmatic hernia surgery that has never been reported before: a late postoperative iatrogenic fistula, between the inferior vena cava and the right lower pulmonary vein, discovered in a 6‐year‐old boy operated at the age of 4 months for a right diaphragmatic hernia. The right to left shunt was completely and uneventfully suppressed by a percutaneous procedure separating the systemic venous return from the pulmonary venous return with an Amplatzer Vascular Plug II. © 2011 Wiley‐Liss, Inc.
Intentionally induced swirling flow may improve the hemodynamic performance of coronary bifurcation stenting
Authors: Sun Anqiang , Fan Yubo , Deng Xiaoyan 
Published: July 2011

AbstractObjectives and Background: Bifurcation stenting represents a challenge for the high rate of restenosis that has close correlations with local hemodynamics. This study sought to test the hypothesis that by intentionally inducing swirling flow the hemodynamic performance of bifurcation stenting can be improved. Methods: The hemodynamics of bifurcation stenting with and without swirling flows were numerically simulated and compared. Results: The results revealed that swirling flow significantly suppressed flow disturbance of blood at the bifurcation and WSS at two critical regions, the outer wall of the bifurcation ostium and the floor wall opposite the branching, was enhanced. Conclusions: This study therefore suggests that intentionally inducing swirling flow might be a good strategy in bifurcation stenting. © 2011 Wiley Periodicals, Inc.
A tale of two pressures: A case of pseudo‐prosthetic mitral valve stenosis
Authors: Bokhari Syed S.I. , O'Neill William W. , Cohen Mauricio G. 
Published: July 2011

AbstractWe present a case of an 83‐year‐old female with past medical history of rheumatic fever associated mitral stenosis for which she underwent mitral commissurotomy 25 years prior to presentation. Subsequently, she underwent coronary artery bypass grafting and mitral valve replacement with a bio‐prosthetic valve 8 years prior to presentation. Presently, she started experiencing worsening dyspnea and heart failure symptoms. Echocardiography showed mildly reduced left ventricular ejection fraction with severe aortic stenosis and pulmonary hypertension. The bioprosthetic mitral valve was functioning normally. We performed right and left heart catheterization for evaluation. Peak aortic gradient was 50 mm Hg with a mean gradient of 39 mm Hg. Aortic valve area was calculated to be 0.31 cm2. However, simultaneous measurement of left ventricular and wedge pressures showed a significant gradient of 11 mm Hg across the mitral valve with a calculated mitral valve area of 0.4 cm2. Because of discordant information between echocardiographic and hemodynamic data, we proceeded with trans‐septal puncture to directly measure left atrial pressures. Simultaneous left atrial and left ventricular pressure measurement demonstrated a mean gradient of 4 mm Hg across the mitral valve with an area calculated at 1.9 cm2. We review the tracings in detail and discuss the pitfalls of using pulmonary capillary wedge pressure as a surrogate for left atrial pressure. © 2011 Wiley Periodicals, Inc.
Total Syntheses of Bryostatins: Synthesis of Two Ring‐Expanded Bryostatin Analogues and the Development of a New‐Generation Strategy to Access the C7–C27 Fragment
Authors: Trost Barry M. , Yang Hanbiao , Dong Guangbin 
Published: July 2011

AbstractHerein, we report the synthesis of novel ring‐expanded bryostatin analogues. By carefully modifying the substrate, a selective and high‐yielding Ru‐catalyzed tandem enyne coupling/Michael addition was employed to construct the northern fragment. Ring‐closing metathesis was utilized to form the 31‐membered ring macrocycle of the analogue. These ring‐expanded bryostatin analogues possess anticancer activity against several cancer cell lines. Given the difficulty in forming the C16–C17 olefin at a late stage, we also describe our development of a new‐generation strategy to access the C7–C27 fragment, containing both the ring B and C subunits.
On the fragmentation of a torus by random walk
Authors: Teixeira Augusto , Windisch David 
Published: July 2011

AbstractWe consider a simple random walk on a discrete torus \input amssym $({\Bbb Z}/N{\Bbb Z})^d$ with dimension d ≥ 3 and large side length N. For a fixed constant u ≥ 0, we study the percolative properties of the vacant set, consisting of the set of vertices not visited by the random walk in its first [uNd] steps. We prove the existence of two distinct phases of the vacant set in the following sense: If u > 0 is chosen large enough, all components of the vacant set contain no more than (log N)λ(u) vertices with high probability as N tends to infinity. On the other hand, for small u > 0, there exists a macroscopic component of the vacant set occupying a nondegenerate fraction of the total volume Nd. In dimensions d ≥ 5, we additionally prove that this macroscopic component is unique by showing that all other components have volumes of order at most (log N)λ(u). Our results thus solve open problems posed by Benjamini and Sznitman, who studied the small u regime in high dimension. The proofs are based on a coupling of the random walk with random interlacements on \input amssym ${\Bbb Z}^d$. Among other techniques, the construction of this coupling employs a refined use of discrete potential theory. By itself, this coupling strengthens a result by Windisch. © 2011 Wiley Periodicals, Inc.