bluuebunny/crossref_metadata_2025_split huggingface dataset:
Le motif du loup chez Rachilde: la règle de l’interdit
Authors: Ouellet François 
Published: April 2012

RÉSUMÉ Cet article propose une lecture d’un roman de Rachilde, Le meneur de louves (1905), où le motif du loup sert à mettre en valeur la prédominance d’un imaginaire régulé par l’interdit de l’inceste. À l’encontre de la critique féministe pour laquelle Rachilde est une auteure qui prescrit un discours amoureux qui pervertit les rapports traditionnels entre l’homme et la femme, il s’agit ici de faire voir comment la volonté de « refaire l’amour » des personnages est imposée par un interdit qui dicte au texte sa lettre. Ce qui écrit le texte, c’est la règle de l’interdit, le discours féministe n’étant alors que le reflet idéologique d’un effet de texte que Rachilde n’a jamais voulu ni cautionné.
Le lieu de « ce qui se répète » : le familial et l'étranger inquiétant
Authors: Trapanese Gemma , Kalman Rudolf , Joubert Christiane 
Published: April 2012

Résumé Ce travail décrit un traitement psychanalytique appliqué à la famille d’une patiente anorexique qui s’oriente vers la découverte du champ de signification latent. En analysant les solutions défensives élaborées contre la douleur par les membres individuellement et par le groupe familial en totalité, les fantasmes inconscients transmis depuis des générations et revécus au contact de l’analyse de l’histoire d’une relation dramatique entre frères ont émergé. En révélant l’« étranger inquiétant », ces fantasmes déployèrent et montrèrent toute une série de représentations depuis le chien-enfant-poupées décapitées jusqu’aux poupées-enfants-tabous « mortes-vivantes », aux fillettes mourantes, au père meurtrier, à la grand-mère immobile à l’intérieur d’un deuil congelé.
L'enfant qui vient ou l'enfant qui revient d'ailleurs ?
Authors: Granjon Evelyn 
Published: April 2012

Résumé L’adoption correspond à des processus d’ affiliation filiative . L’enfant adopté réveille la dette généalogique familiale et l’amène parfois à figurer l’inconnu transgénérationnel. À partir de cette phrase : « c’est un enfant adopté » souvent entendue et déposée à l’occasion d’une demande, l’auteur propose de suivre le travail de figuration-représentation qui se fait dans l’espace psychique du groupe de TFP. Certains mots ou objets déposés dans le néo-groupe viennent figurer la condensation d’éléments noués dans les alliances inconscientes des liens familiaux, en particulier le lien d’adoption. Le travail thérapeutique favorise une décondensation des « inconnus des origines » et permet une reprise de la mythopoïèse familiale .
Angoisse de séparation et angoisse d'abandon au cœur du lien adoptif
Authors: Duvert Anne-Claude 
Published: April 2012

Résumé	L’adoption, dans la mesure où elle est la réalisation d’un rêve, repose sur la croyance en la toute-puissance réparatrice du lien affectif. Beaucoup d’émotions sont en jeu, nécessaires au développement du lien adoptif. Elles le fragilisent et à la fois le fortifient. L’aspect fusionnel du lien observé pourrait être lié au fantasme d’avoir « volé » un enfant. Le vécu d’abandon et de souffrance de l’enfant peut aussi entrer en résonance avec des éléments traumatiques non résolus du passé des adoptants. Par ailleurs, l’angoisse de la perte du lien peut être réactivée quand l’enfant quitte sa famille à l’adolescence. Le rôle des intermédiaires et des thérapeutes de l’adoption sera de contenir angoisses et émotions et d’aider parents et enfants à les transformer en expériences émotionnelles durables.
Parent pauvre ou parent fragile ?
Authors: Pierron Jean-Philippe 
Published: April 2012

Résumé L’expérience adoptive touche au fondement même de ce qui nous lie les uns aux autres. Elle sonde les racines du lien de filiation, en en interrogeant la nature. À l’évidence des liens qui paraissent naturels, les liens du sang, l’adoption oppose la fragilité d’un lien de mutualité. Par là, plutôt qu’être un lien parental par défaut, le lien adoptif éclaire tout lien parental : si l’engendrement est de nature, la parenté est de désignation. Devenant le prototype du parental, le lien adoptif affirme alors qu’il n’y a pas de naissance qui n’attende sa reconnaissance.
Familles à caractère abandonnique. Spécificité des associations groupales
Authors: Forissier Anne , Savin Bernard 
Published: April 2012

Résumé Dans ce travail, nous avons cherché à voir s’il pouvait exister une spécificité de la chaîne associative verbale des familles abandonniques produite en séances de Thérapie familiale psychanalytique. Nous avons repéré que cette chaîne associative verbale peut être observée à deux niveaux : celui de sa structure (coupures, interruptions, superposition des discours) et celui de son contenu c’est-à-dire des images qui la constituent, génératrices d’éprouvés ou de sidération pour les thérapeutes.
La dimension spatiale des inégalités. Regards croisés des sciences sociales
Authors: Vettraino Jean 
Published: April 2012

Résumé Isabelle Backouche, Fabrice Ripoll, Sylvie Tissot et Vincent Veschambre (dir.), La dimension spatiale des inégalités. Regards croisés des sciences sociales , Presses universitaires de Rennes, 2011, 357 p., 22 €
The Role of Naive T Cell Precursor Frequency and Recruitment in Dictating Immune Response Magnitude
Authors: Jenkins Marc K. , Moon James J. 
Published: April 2012

Abstract
Recent advances in technology have led to the realization that the populations of naive T cells specific for different foreign peptide:MHC (p:MHC) ligands vary in size. This variability is due, in part, to the fact that certain peptides contain amino acids that engage in particularly favorable interactions with TCRs. In addition, deletion of clones with cross-reactivity for self-p:MHC ligands may reduce the size of some naive populations. In many cases, the magnitude of the immune response to individual p:MHC epitopes correlates with the size of the corresponding naive populations. However, this simple relationship may be complicated by variability in the efficiency of T cell recruitment into the immune response. The knowledge that naive population size can predict immune response magnitude may create opportunities for production of more effective subunit vaccines.
On Mertens' Theorem for Beurling Primes
Authors: Pollack Paul 
Published: April 2012

Abstract.Let 1 < p1 ≤ p2 ≤ p3 ≤ … be an infinite sequence ℘ of real numbers for which pi → 1, and associate with this sequence the Beurling zeta function . Suppose that for some constant A > 0, we have . We prove that ℘ satisfies an analogue of a classical theorem of Mertens: . Here e = 2.71828 … is the base of the natural logarithm and γ= 0.57721 … is the usual Euler–Mascheroni constant. This strengthens a recent theorem of Olofsson.
Inclusion Relations for New Function Spaces on Riemann Surfaces
Authors: Aulaskari Rauno , Jouni Rättyä  
Published: April 2012

Abstract.We introduce and study some new function spaces on Riemann surfaces. For certain parameter values these spaces coincide with the classical Dirichlet space, BMOA, or the recently defined Qp space. We establish inclusion relations that generalize earlier known inclusions between the above-mentioned spaces.
On Induced Representations Distinguished by Orthogonal Groups
Authors: Valverde Cesar 
Published: April 2012

Abstract.LetFbe a local non-archimedean field of characteristic zero. We prove that a representation ofGL(n,F) obtained from irreducible parabolic induction of supercuspidal representations is distinguished by an orthogonal group only if the inducing data is distinguished by appropriate orthogonal groups. As a corollary, we get that an irreducible representation induced from supercuspidals that is distinguished by an orthogonal group is metic.
Subadditivity Inequalities for Compact Operators
Authors: Bourin Jean-Christophe , Harada Tetsuo , Lee Eun-Young 
Published: April 2012

AbstractSome subadditivity inequalities for matrices and concave functions also hold for Hilbert space operators, but (unfortunately!) with an additional ε term. It does not seem possible to erase this residual term. However, in case of compact operators we show that the ε term is unnecessary. Further, these inequalities are strict in a certain sense when some natural assumptions are satisfied. The discussion also emphasizes matrices and their compressions and several open questions or conjectures are considered, both in the matrix and operator settings.
A Short Proof of Paouris' Inequality
Authors: Adamczak Radosław , Latała Rafał , Litvak Alexander E. , Oleszkiewicz Krzysztof , Pajor Alain , Tomczak-Jaegermann Nicole 
Published: April 2012

AbstractWe give a short proof of a result of G. Paouris on the tail behaviour of the Euclidean norm |X| of an isotropic log-concave random vector X ∈ ℝn; stating that for every t ≥ 1,More precisely we show that for any log-concave random vector X and any p ≥ 1,
Concise Catalytic Asymmetric Total Synthesis of Biologically Active Tropane Alkaloids
Authors: Córdova Armando , Lin Shuangzheng , Tseggai Abrehet 
Published: April 2012

AbstractA general strategy for the total asymmetric synthesis of valuable tropane alkaloids by catalytic stereoselective transformations is disclosed. The power of this approach is exemplified by the concise catalytic enantioselective total syntheses of (+)‐methylecgonine, (−)‐cocaine and (+)‐cocaine as well as the first catalytic asymmetric total syntheses of a cocaine C‐1 derivative and (+)‐ferruginine starting from 5‐oxo‐protected‐α,β‐unsaturated enals using only two and three column chromatographic purification steps, respectively.
A randomized trial of mesenchymal stem cells in multiple system atrophy
Authors: Lee Phil Hyu , Lee Ji E. , Kim Han‐Soo , Song Sook K. , Lee Hye Sun , Nam Hyo Suk , Cheong June‐Won , Jeong Yong , Park Hae‐Jeong , Kim Dong Joon , Nam Chung Mo , Lee Jong Doo , Kim Hyun Ok , Sohn Young H. 
Published: April 2012

AbstractObjective:Neuroprotective or regenerative strategies are invaluable in multiple system atrophy (MSA) due to its rapid progression with fatal prognosis. We evaluated the efficacy of autologous mesenchymal stem cells (MSC) in patients with MSA‐cerebellar type (MSA‐C).Methods:Thirty‐three patients with probable MSA‐C and baseline unified MSA rating scale (UMSARS) scores ranging from 30 to 50 were randomly assigned to receive MSC (4 × 107/injection) via intra‐arterial and intravenous routes or placebo. The primary outcome was change in the total UMSARS scores from baseline throughout a 360‐day follow‐up period between groups. Secondary outcomes were changes in the UMSARS part II scores, cerebral glucose metabolism, gray matter density, and cognitive performance over a 360‐day period.Results:The mixed model analysis of neurological deficits revealed a significant interaction effect between treatment group and time, suggesting that the MSC group had a smaller increase in total and part II UMSARS scores compared with the placebo group (p = 0.047 and p = 0.008, respectively). Cerebral glucose metabolism and gray matter density at 360 days relative to the baseline were more extensively decreased in the cerebellum and the cerebral cortical areas, along with greater deterioration of frontal cognition in the placebo group compared with the MSC group. We found no serious adverse effects that were directly related to MSC treatment. However, intra‐arterial infusion resulted in small ischemic lesions on magnetic resonance imaging.Interpretation:MSC therapy could delay the progression of neurological deficits in patients with MSA‐C, suggesting the potential of MSC therapy as a treatment candidate of MSA. ANN NEUROL 2012;72:32–40
Risk in complex genetics: “All models are wrong but some are useful”
Authors: Sawcer Stephen , Wason James 
Published: April 2012

AbstractAlthough genome‐wide association studies (GWAS) have proven remarkably effective at identifying reliably associated genetic variants, the biology underlying these discoveries is rarely immediately apparent and in most cases seems bound to require extensive fine mapping and functional analysis before it is revealed. In this context, it is logical and appropriate to try to interrogate available genetic data for biological insights. However, because such efforts invariably depend upon mathematical modeling, misperceptions can easily arise if the relevant mathematical properties are overlooked or forgotten. In this report, we will examine these mathematical issues, highlight some of the more common misconceptions, and hopefully help to clarify the somewhat blurry distinction between biology and mathematics that can so easily undermine and obscure the value of GWAS discoveries. ANN NEUROL 2012;72:502–509
Subthalamic discharges as a causal determinant of parkinsonian motor deficits
Authors: Tai Chun‐Hwei , Pan Ming‐Kai , Lin Janice Janing , Huang Chen‐Syuan , Yang Ya‐Chin , Kuo Chung‐Chin 
Published: April 2012

AbstractObjective:We have reported that intrinsic membrane properties, especially T‐type Ca2+ channels, play a key role in the genesis of burst discharges in the subthalamic nucleus (STN) and parkinsonian locomotor symptoms. Whether deep brain stimulation (DBS) exerts its clinical benefits on Parkinson disease (PD) with changes in T currents or other conductances, however, remains elusive.Methods:Different stimulation protocols, including constant currents of opposite polarity, were applied to STN in vivo or in vitro, and the electrophysiological and behavioral effects were documented in normal and parkinsonian rodents. The effect of correlatively adjusted DBS protocols was also explored in 3 PD patients.Results:Delivery of negative constant current into STN dramatically ameliorated locomotor deficits in parkinsonian rats. It also depolarized STN neurons and decreased T‐channel availability as well as burst discharges. In contrast, delivery of positive constant currents to STN induced PD‐like locomotor deficits and increased STN burst discharges in normal rats. In addition, the therapeutic effect of DBS was greatly improved in 3 PD patients simply by increasing the pulse width from 60 to 240 microseconds, even at a lower stimulation frequency of 60Hz.Interpretation:The increased tendency of STN burst discharges may by itself serve as a direct cause of parkinsonian locomotor deficits, even in the absence of deranged dopaminergic innervation. Effective DBS therapy in PD very likely relies on adequate depolarization, and consequent modification of the relevant ionic currents and discharge patterns, of STN neurons. ANN NEUROL 2012;72:464–476.
Biomedical applications of dipeptides and tripeptides
Authors: Santos Sara , Torcato Inês , Castanho Miguel A. R. B. 
Published: April 2012

AbstractPeptides regulate many physiological processes, acting at some sites as endocrine or paracrine signals and at others as neurotransmitters or growth factors, for instance. These molecules represent a major evolution in medical and industrial fields, as it is becoming mandatory to design and exploit molecules that do not necessarily fit the description of classical drug classes. The list of peptides with potential biomedical applications is huge and is growing each year. These biomedical applications range from uses as drugs to flavor‐active peptides as ingredients in natural health products, nutraceuticals and functional foods. Among the peptide family, dipeptides and tripeptides are very appealing for drug discovery and development because of their cost‐effectiveness, possibility of oral administration, and simplicity to perform molecular structural and quantitative structure‐activity studies. Our objective is to review different actual and future uses of dipeptides and tripeptides as well as the major advances and obstacles in this growing area. © 2012 Wiley Periodicals, Inc. Biopolymers (Pept Sci) 98: 288–293, 2012.
A novel chitin‐binding protein fromMoringa oleiferaseed with potential for plant disease control
Authors: Gifoni Juliana M. , Oliveira José T. A. , Oliveira Hermogenes D. , Batista Adelina B. , Pereira Mirella L. , Gomes Antoniella S. , Oliveira Henrique P. , Grangeiro Thalles B. , Vasconcelos Ilka M. 
Published: April 2012

AbstractA thermostable chitin‐binding protein (14.3 kDa) with antifungal activity was isolated fromMoringa oleiferaseeds by affinity chromatography on chitin followed by ion exchange chromatography. NH2‐CPAIQRCCQQLRNIQPPCRCCQ (Mo‐CBP3) is a glycoprotein with 2.5% sugar, pI 10.8, without hemagglutination, chitinase or β‐glucanase activities.Mo‐CBP3possesses in vitro antifungal activity against the phytopathogenic fungiFusarium solani, F. oxysporum, Colletotrichum musaeandC. gloesporioides. Contrarily,Mo‐CBP3did not affectPythium oligandrum, an oomycete. At 0.05 mg/ml,Mo‐CBP3showed to be fungistatic againstF. solani, but at 0.1 mg/mlMo‐CBP3behaved as a potent fungicidal agent as it inhibited both the spore germination and mycelial growth ofF. solani. Surprisingly, the effect ofMo‐CBP3against spore germination was observed even when the protein was heated at 100°C for 1 h or pretreated with 0.15MN‐acetyl‐D‐glucosamine.Mo‐CBP3inhibited the glucose‐stimulated acidification of the incubation medium byF. solani. This is apparently caused by structural plasma membrane disarrangement induced byMo‐CBP3. Altogether, these results suggest thatMo‐CBP3might be involved in plant defense mechanisms and could be used as potential antifungal agent for controlling fungal pathogens in plants. © 2012 Wiley Periodicals, Inc. Biopolymers (Pept Sci) 98: 406–415, 2012.
Cn‐AMP1: A new promiscuous peptide with potential for microbial infections treatment
Authors: Silva Osmar N. , Porto William F. , Migliolo Ludovico , Mandal Santi M. , Gomes Diego G. , Holanda Hortência H. S. , Silva Rosa S. P. , Dias Simoni C. , Costa Maysa P. , Costa Carolina R. , Silva Maria R. , Rezende Taia M. B. , Franco Octavio L. 
Published: April 2012

AbstractThe antimicrobial peptides (AMPs) are evolutionarily ancient molecules that act as components of the innate immune system. Recently, it was demonstrated that a single AMP can perform various functions; this ability is known as “peptide promiscuity.” However, little is known about promiscuity in plant AMPs without disulfide bonds. This study was carried out to evaluate the promiscuity of Cn‐AMP1: a promising disulfide‐free plant peptide with reduced size and cationic and hydrophobic properties. Its activity against human pathogenic bacteria and fungal pathogens, as well as its in vitro immunostimulatory activity and effects on cancerous and healthy mammalian cell proliferation were studied here. Cn‐AMP1 exerts antimicrobial effects against Gram‐positive bacteria, Gram‐negative bacteria, and fungi. Moreover, tumor cell viability activity in Caco‐2 cells, as well as immunostimulatory activity by evaluating upregulated inflammatory‐cytokine secretion by monocytes was also positively observed. Cn‐AMP1 does not exhibit a well‐defined conformation in aqueous solution and probably undergoes a 310‐helix transition in hydrophobic environments. The experimental results support the promiscuous activity of Cn‐AMP1, presenting a wide range of activities, including antibacterial, antifungal, and immunostimulatory activity. In the future, Cn‐AMP1 should be used in the development of novel biopharmaceuticals, mainly due to its reduced size and broad spectrum of activity. © 2012 Wiley Periodicals, Inc. Biopolymers (Pept Sci) 98: 322–331, 2012.
Optimization of co‐agonism at GLP‐1 and glucagon receptors to safely maximize weight reduction in DIO‐rodents
Authors: Day Jonathan W. , Gelfanov Vasily , Smiley David , Carrington Paul E. , Eiermann George , Chicchi Gary , Erion Mark D. , Gidda Jas , Thornberry Nancy A. , Tschöp Matthias H. , Marsh Donald J. , SinhaRoy Ranabir , DiMarchi Richard , Pocai Alessandro 
Published: April 2012

AbstractThe ratio of GLP‐1/glucagon receptor (GLP1R/GCGR) co‐agonism that achieves maximal weight loss without evidence of hyperglycemia was determined in diet‐induced obese (DIO) mice chronically treated with GLP1R/GCGR co‐agonist peptides differing in their relative receptor agonism. Using glucagon‐based peptides, a spectrum of receptor selectivity was achieved by a combination of selective incorporation of GLP‐1 sequences, C‐terminal modification, backbone lactam stapling to stabilize helical structure, and unnatural amino acid substitutions at the N‐terminal dipeptide. In addition to α‐amino‐isobutyric acid (Aib) substitution at position two, we show that α,α′‐dimethyl imidazole acetic acid (Dmia) can serve as a potent replacement for the highly conserved histidine at position one. Selective site‐specific pegylation was used to further minimize enzymatic degradation and provide uniform, extended in vivo duration of action. Maximal weight loss devoid of any sign of hyperglycemia was achieved with a co‐agonist comparably balanced for in vitro potency at murine GLP1R and GCGR. This peptide exhibited superior weight loss and glucose lowering compared to a structurally matched pure GLP1R agonist, and to co‐agonists of relatively reduced GCGR tone. Any further enhancement of the relative GCGR agonist potency yielded increased weight loss but at the expense of elevated blood glucose. We conclude that GCGR agonism concomitant with GLP1R agonism constitutes a promising approach to treatment of the metabolic syndrome. However, the relative ratio of GLP1R/GCGR co‐agonism needs to be carefully chosen for each species to maximize weight loss efficacy and minimize hyperglycemia. © 2012 Wiley Periodicals, Inc. Biopolymers (Pept Sci) 98: 443–450, 2012.
A single nucleotide polymorphism in ycdC alters tRNA synthetase expression and results in hypersecretion in Escherichia coli
Authors: Gupta Prateek , Swanberg Jeffrey C. , Lee Kelvin H. 
Published: April 2012

AbstractThe most important approach to the development of platform organisms for recombinant protein production relies on random mutagenesis and phenotypic selection. Complex phenotypes, including those associated with significantly elevated expression and secretion of heterologous proteins, are the result of multiple genomic mutations. Using next generation sequencing, a parent and derivative hypersecreter strain (B41) of Escherichia coli were sequenced with an average coverage of 52.8X and 55X, respectively. A new base‐pair calling program, revealed a single nucleotide polymorphism in the B41 genome at position 1,074,787, resulting in translation termination near the N‐terminus of a transcriptional regulator protein, RutR, coded by the ycdC gene. We verified the hypersecretion phenotype in a ycdC::Tn5 mutant and observed a 3.4‐fold increase in active hemolysin secretion, consistent with the increase observed in B41 strain. mRNA expression profiling showed decreased expression of tRNA‐synthetases and some amino acid transporters in the ycdC::Tn5 mutant. This study demonstrates the power of next generation sequencing to characterize mutants leading to successful metabolic engineering strategies for strain improvement. © 2012 American Institute of Chemical Engineers Biotechnol. Prog., 2012