bluuebunny/crossref_metadata_2025_split huggingface dataset:
ACCF/SCAI/AATS/AHA/ASE/ASNC/HFSA/HRS/SCCM/SCCT/SCMR/STS 2012 appropriate use criteria for diagnostic catheterization
Authors: Patel Manesh R. , Bailey Steven R. , Bonow Robert O. , Chambers Charles E. , Chan Paul S. , Dehmer Gregory J. , Kirtane Ajay J. , Wann L. Samuel , Ward R. Parker , Douglas Pamela S. , Patel Manesh R. , Bailey Steven R. , Altus Philip , Barnard Denise D. , Blankenship James C. , Casey Donald E. , Dean Larry S. , Fazel Reza , Gilchrist Ian C. , Kavinsky Clifford J. , Lakoski Susan G. , Le D. Elizabeth , Lesser John R. , Levine Glenn N. , Mehran Roxana , Russo Andrea M. , Sorrentino Matthew J. , Williams Mathew R. , Wong John B. , Wolk Michael J. , Bailey Steven R. , Douglas Pamela S. , Hendel Robert C. , Kramer Christopher M. , Min James K. , Patel Manesh R. , Shaw Leslee , Stainback Raymond F. , Allen Joseph M. 
Published: June 2012

AbstractThe American College of Cardiology Foundation, in collaboration with the Society for Cardiovascular Angiography and Interventions and key specialty and subspecialty societies, conducted a review of common clinical scenarios where diagnostic catheterization is frequently considered. The indications (clinical scenarios) were derived from common applications or anticipated uses, as well as from current clinical practice guidelines and results of studies examining the implementation of noninvasive imaging appropriate use criteria. The 166 indications in this document were developed by a diverse writing group and scored by a separate independent technical panel on a scale of 1 to 9, to designate appropriate use (median 7 to 9), uncertain use (median 4 to 6), and inappropriate use (median 1 to 3). Diagnostic catheterization may include several different procedure components. The indications developed focused primarily on 2 aspects of diagnostic catheterization. Many indications focused on the performance of coronary angiography for the detection of coronary artery disease with other procedure components (e.g., hemodynamic measurements, ventriculography) at the discretion of the operator. The majority of the remaining indications focused on hemodynamic measurements to evaluate valvular heart disease, pulmonary hypertension, cardiomyopathy, and other conditions, with the use of coronary angiography at the discretion of the operator. Seventy‐five indications were rated as appropriate, 49 were rated as uncertain, and 42 were rated as inappropriate. The appropriate use criteria for diagnostic catheterization have the potential to impact physician decision making, healthcare delivery, and reimbursement policy. Furthermore, recognition of uncertain clinical scenarios facilitates identification of areas that would benefit from future research. © 2012 Wiley Periodicals, Inc.
Molecular and organismal changes in offspring of male mice treated with chemical stressors
Authors: Shiao Yih‐Horng , Leighty Robert M. , Wang Cuiju , Ge Xin , Crawford Erik B. , Spurrier Joshua M. , McCann Sean D. , Fields Janet R. , Fornwald Laura , Riffle Lisa , Driver Craig , Kasprzak Kazimierz S. , Quiñones Octavio A. , Wilson Ralph E. , Travlos Gregory S. , Alvord W. Gregory , Anderson Lucy M. 
Published: June 2012

AbstractBoth gene methylation changes and genetic instability have been noted in offspring of male rodents exposed to radiation or chemicals, but few specific gene targets have been established. Previously, we identified the gene for ribosomal RNA, rDNA, as showing methylation change in sperm of mice treated with the preconceptional carcinogen, chromium(III) chloride. rDNA is a critical cell growth regulator. Here, we investigated the effects of paternal treatments on rDNA in offspring tissue. A total of 93 litters and 758 offspring were obtained, permitting rigorous mixed‐effects models statistical analysis of the results. We show that the offspring of male mice treated with Cr(III) presented increased methylation in a promoter sequence of the rDNA gene, specifically in lung. Furthermore polymorphic variants of the multi‐copy rDNA genes displayed altered frequencies indicative of structural changes, as a function of both tissue type and paternal treatments. Organismal effects also occurred: some groups of offspring of male mice treated with either Cr(III) or its vehicle, acidic saline, compared with those of untreated mice, had altered average body and liver weights and levels of serum glucose and leptin. Males treated directly with Cr(III) or acidic saline presented serum hormone changes consistent with a stress response. These results establish for the first time epigenetic and genetic instability effects in a gene of central physiological importance, in offspring of male mice exposed preconceptionally to chemicals, possibly related to a stress response in these males. © 2012 Wiley Periodicals, Inc.
The accessibility of vulnerable groups to health services in Greece: a Delphi study on the perceptions of health professionals
Authors: Karamitri Ioanna , Bellali Thalia , Galanis Petros , Kaitelidou Daphne 
Published: June 2012

SUMMARYBackgroundProblems of accessibility to healthcare services notably affect certain population groups such as poor and unemployed people, migrants and minorities, thus having a negative impact on their health. The aim of this study was to investigate these problems from the perspective of health professionals and to formulate empirically informed suggestions to solve the issue.MethodsPrimary data were collected in 2010–2011 by using a panel of 36 experienced health professionals around Greece. A two‐round Delphi method was undertaken to achieve the objectives of the study. The first questionnaire investigated the factors that hinder accessibility to health services. The second round aimed at determining the relative importance of each of the factors emerging in the first round.ResultsThe group of experts identified 345 factors in the first round, which were grouped in 55 statements. Consensus was achieved in 22 statements. The study revealed important issues, and health professionals proposed a number of actions to eliminate the accessibility problems.ConclusionsThe use of medical interpreters and cultural mediators, transcultural education and stronger linkages among medical facilities are important to reduce accessibility problems. Restructuring primary healthcare and better documenting of the beneficiaries could also improve the quality of provided healthcare services. Copyright © 2012 John Wiley & Sons, Ltd.
Regional evapotranspiration rate of oasis and surrounding desert
Authors: Jia Jihong , Zhao Wenzhi , Li Shoubo 
Published: June 2012

AbstractThe surface energy balance algorithm for land method was used in this study to calculate the evapotranspiration (ET) rate for the middle reaches of the Heihe River Basin, Gansu Province, China, to analyse ET distribution within the oasis and the surrounding desert and, especially, on the edge zone of the oasis. Five profile graphs were created vertical to the river. Because of the inverse humidity phenomenon, the least amount of evapotranspiration occurred on the desert close to the oasis. The average evapotranspiration rate was roughly proportioned from the edge of the oasis to inside and outside its boundary. Two meteorological ground stations located close to the oasis edge showed a notable difference in net radiation flux that led to the difference found in ET. The primary reason for the significant differences observed in net radiation may be largely the result of differences in flux reflectivity and surface temperature. Meteorological data show that water supply also played an important role. Copyright © 2012 John Wiley & Sons, Ltd.
Fine scale variations of surface water chemistry in an ephemeral to perennial drainage network
Authors: Zimmer Margaret A. , Bailey Scott W. , McGuire Kevin J. , Bullen Thomas D. 
Published: June 2012

AbstractAlthough temporal variation in headwater stream chemistry has long been used to document baseline conditions and response to environmental drivers, less attention is paid to fine scale spatial variations that could yield clues to processes controlling stream water sources. We documented spatial and temporal variation in water composition in a headwater catchment (41 ha) at the Hubbard Brook Experimental Forest, NH, USA. We sampled every 50 m along an ephemeral to perennial stream network as well as groundwater from seeps and 35 shallow wells across varying flow conditions. Groundwater influences on surface water in this region have not been considered to be important in past studies as relatively coarse soils were assumed to be well drained in steep catchments with flashy runoff response. However, seeps displayed perennial discharge, upslope accumulated areas (UAA) smaller than those for channel initiation sites and higher pH, Ca and Si concentrations than streams, suggesting relatively long groundwater residence time or long subsurface flow paths not bound by topographic divides. Coupled with a large range in groundwater chemistry seen in wells, these results suggest stream chemistry variation reflects the range of connectivity with, and quality of, groundwater controlled by hillslope hydropedological processes. The magnitude of variations of solute concentrations seen in the first order catchment was as broad as that seen at the fifth order Hubbard Brook Valley (3519 ha). Reduction in variation in solute concentrations with increasing UAA suggested a representative elementary area (REA) value of less than 3 ha in the first order catchment, compared with 100 ha for the fifth order basin. Thus, the REA is not necessarily an elementary catchment property. Rather, the partitioning of variation between highly variable upstream sources and relatively homogenous downstream characteristics may have different physical significance depending on the scale and complexity of the catchment under examination. Copyright © 2012 John Wiley & Sons, Ltd.
Entrapment of Saccharomyces cerevisiae and 3T3 fibroblast cells into blue light cured hydrogels
Authors: Mishra Swati , Scarano Frank J. , Calvert Paul 
Published: June 2012

AbstractHydrogels, containing yeast cells or fibroblast cells, were fabricated using blue light‐induced polymerization technique. The cell‐loaded prepolymer formulation was comprised of poly(ethyleneglycol) diacrylate (more than or equal to 50% v/v), 0.5 wt % Eosin Y and 0.5 wt % triethanolamine as the base oligomer, photo‐initiator, and co‐initiator, respectively. The two model cell lines, Saccharomyces cerevisiae and NIH 3T3 fibroblasts maintained high viability pre‐ and post‐processing. Several bioassays have demonstrated the unaffected intracellular and extracellular activities of the cells entrapped within the hydrogels. Scanning electron microscopy confirmed the proliferation of S. cerevisiae cells that were entrapped and cultivated for 48 h in growth media, which validated the favorable microenvironment and nutrient transport in these gels. Upon entrapment, fibroblast cells remain viable upto 12 h, however they failed to attach within the crosslinked network, thus no further proliferation was observed. The tunable properties of this hydrogel system project it as a useful matrix for specialized biohybrids. © 2012 Wiley Periodicals, Inc. J Biomed Mater Res Part A 100A:2829–2838, 2012.
Caudatin inhibits carcinomic human alveolar basal epithelial cell growth and angiogenesis through modulating GSK3β/β‐catenin pathway
Authors: Fei Hong‐Rong , Cui Li‐Yuan , Zhang Zhao‐Rui , Zhao Ying , Wang Feng‐Ze 
Published: June 2012

AbstractIn this study, we investigate the anti‐cancer activity of caudatin in carcinomic human alveolar basal epithelial cell line A549 and anti‐angiogenic activity in human umbilical vein endothelial cells (HUVECs). We show that caudatin impairs the cell viability and induces G0/G1 phase arrest in A549 cells with a dose dependent manner. A549 cells, not HUVECs, dealing with caudatin exhibited typical characteristics of apoptosis, which were accompanied by activation of caspase‐3, caspase‐9 and Poly(ADP–Ribose) Polymerase (PARP). In addition, caudatin treatment resulted in a decrease of β‐catenin and increase of phosphorylation of β‐catenin, and inhibited phosphorylation levels of GSK3β (Ser 9) in A549 cells. Conditional medium of A549 cells‐induced or growth factors‐induced tube formation of HUVECs was markedly inhibited by caudatin treatment, which was associated with the inhibiting VEGF secretion from A549 cells by caudatin. Our findings suggest that caudatin inhibits carcinomic human alveolar basal epithelial cell growth and angiogenesis by targeting GSK3β/β‐catenin pathway and suppressing VEGF production. J. Cell. Biochem. 113: 3403–3410, 2012. © 2012 Wiley Periodicals, Inc.
Dioscoreanone suppresses LPS‐induced nitric oxide production and inflammatory cytokine expression in RAW 264.7 macrophages by NF‐κB and ERK1/2 signaling transduction
Authors: Itharat Arunporn , Hiransai Poonsit 
Published: June 2012

AbstractDioscoreanone, a 1,4‐phenanthraquinone isolated from an ethanolic extract of the rhizome of Dioscorea membranacea, Pierre ex Prain & Burkill, a plant which has been used to treat inflammation and cancer in Thai Traditional Medicine. In this study, the mechanisms of dioscoreanone on LPS‐induced NO production and cytokine expression through the activation of NF‐κB and ERK1/2 are demonstrated in RAW 264.7 cells. Through measurement with Griess reagent, dioscoreanone was found to reduce NO levels with an IC50 value of 2.50 ± 0.64 µM, due to the significant suppression of LPS‐induced iNOS mRNA expression, as well as IL‐1β and IL‐6 levels at a concentration of 6 µM. At the signal transduction level, using the pNFκB‐Luciferase reporter system, dioscoreanone significantly inhibited NF‐κB transcriptional activity, which resulted from the prevention of IκBα degradation. In addition, dioscoreanone in the range of 1.2–5 µM significantly enhanced LPS‐induced ERK1/2 activation and dioscoreanone alone induced the activation of ERK1/2 proteins in a concentration‐ and time‐dependent response. The activation of ERK1/2 proteins by dioscoreanone was due to both an arylating reaction, which was suppressed by N‐acetyl cysteine, and a redox cycling reaction of NQOR, which was inhibited by dicoumarol. In conclusion, the mechanisms of dioscoreanone on the inhibition of NO production and mRNA expression of iNOS, IL‐1β, and IL‐6 were due to both the inhibition of NF‐κB activation and the activation of ERK1/2 proteins. The activation of dioscoreanone may in turn inhibit the binding of NF‐κB to pro‐inflammatory gene promoters in LPS‐induced RAW264.7 macrophage cells. J. Cell. Biochem. 113: 3427–3435, 2012. © 2012 Wiley Periodicals, Inc.
Wedelolactone inhibits adipogenesis through the ERK pathway in human adipose tissue‐derived mesenchymal stem cells
Authors: Lim Seyoung , Jang Hyun‐Jun , Park Eun Hee , Kim Jung Kuk , Kim Jung‐Min , Kim Eung‐Kyun , Yea Kyungmoo , Kim Yun‐Hee , Lee‐Kwon Whaseon , Ryu Sung Ho , Suh Pann‐Ghill 
Published: June 2012

AbstractWedelolactone is an herbal medicine that is used to treat septic shock, hepatitis and venom poisoning. Although in differentiated and cancer cells, wedelolactone has been identified as anti‐inflammatory, growth inhibitory, and pro‐apoptotic, the effects of wedelolactone on stem cell differentiation remain largely unknown. Here, we report that wedelolactone inhibits the adipogenic differentiation of human adipose tissue‐derived mesenchymal stem cells (hAMSCs). Wedelolactone reduced the formation of lipid droplets and the expression of adipogenesis‐related proteins, such as CCAAT enhancer‐binding protein‐α (C/EBP‐α), peroxisome proliferator‐activated receptor‐γ (PPAR‐γ), lipoprotein lipase (LPL), and adipocyte fatty acid‐binding protein aP2 (aP2). Wedelolactone mediated this process by sustaining ERK activity. In addition, inhibition of ERK activity with PD98059 resulted in reversion of the wedelolactone‐mediated inhibition of adipogenic differentiation. Taken together, these results indicate that wedelolactone inhibits adipogenic differentiation through ERK pathway and suggest a novel inhibitory effect of wedelolactone on adipogenic differentiation in hAMSCs. J. Cell. Biochem. 113: 3436–3445, 2012. © 2012 Wiley Periodicals, Inc.
Identifying Hypothesis Confirmation Behaviors in a Simulated Murder Investigation: Implications for Practice
Authors: Wastell Colin , Weeks Nicole , Wearing Alexander , Duncan Piers 
Published: June 2012

AbstractInvestigators have been shown to be prone to accessing information that confirms their preferred hypothesis. This tendency has been termed hypothesis confirmation. Hypothesis confirmation behaviour was explored in two studies using a computer administered simulation of a murder investigation. In Study 1, hypothesis confirmation behaviour did not differentiate successful and unsuccessful participants. However, unsuccessful participants stored more confirmatory information than non‐confirmatory information. Successful participants did not show this pattern. In Study 2, unsuccessful participants tended to settle early on a suspect and then acquired information that supported their decision. Successful participants tended to consider a number of suspects for longer and accessed a greater diversity of information. Taken together, these findings are highly suggestive of the role of information acquisition as an important component of hypothesis confirmatory behaviour, which is associated with unsuccessful information processing in the context of a simulated murder investigation. Implications for practice are presented. Copyright © 2012 John Wiley & Sons, Ltd.
Winter temperature extremes in China and their possible causes
Authors: You Qinglong , Ren Guoyu , Fraedrich Klaus , Kang Shichang , Ren Yuyu , Wang Pengling 
Published: June 2012

AbstractCold and warm temperature extremes predominantly occurring in winter gained much more attention than mean temperatures. On the basis of daily maximum and minimum surface air temperature records at 303 meteorological stations in China, the spatial and temporal distributions of five indices for winter (DJF: December, subsequent January and February) temperature extremes are analysed during 1961–2003. For the majority of stations, the frequency of cold days/nights decreases by − 1.33/− 2.98 and warm days/nights increases by 0.92/2.35 d/decade, respectively. Cold days/nights are significantly negatively correlated with the Arctic Oscillation (AO) index, while warm days/nights are positively correlated with the AO. The diurnal temperature range (DTR) has a declining trend with rate of − 0.25 °C/decade and positive correlation with the AO index. Compared with other regions in China, stations in the northern China have larger trend magnitudes and stronger correlations with the AO index, and the AO can explain more than 50% of winter temperature extreme change in China. Compared with the annual basis, the winter temperature extremes have larger trend magnitudes, which reflect the rapid warming. During strongly positive AO index years, enhanced contrast tropospheric temperature (defined as the average of air temperature vertically integrated between 200 hPa and 1000 hPa based on the National Centers for Environmental Prediction/National Center for Atmospheric Research reanalysis) between the north of China and the southern China weakens the East Asian winter monsoon which in turn reduces cold outbreaks in the northern and eastern China. The composites of large‐scale atmospheric circulation are consistent with the asymmetrical changes of the geopotential height, zonal and meridional winds at high and mid latitudes at troposphere. Meanwhile, the linkage between the AO and solar activity also modulates the winter temperature extremes, while the mechanism needs to be investigated. Copyright © 2012 Royal Meteorological Society
Important factors for long‐term change in ENSO transitivity
Authors: Ohba Masamichi 
Published: June 2012

AbstractEl Niño and La Niña exhibit significant asymmetry in their duration. El Niño tends to turn rapidly into La Niña after the mature, while La Niña tends to persist for up to 2 years. Reconstructed historical sea surface temperatures (SST) show a significantly increase in the intensity of El Niño‐Southern Oscillation (ENSO) asymmetry, particularly El Niño transitivity, during the last six decades. Atmospheric observational data have shown that the relationship between El Niño and surface zonal wind anomalies over the equatorial Western Pacific (WP) has strengthened, and anomalous WP easterlies have appeared after the 1970s climate regime shift. To investigate the dependency of ENSO transitivity on its amplitude, a suite of idealized experiments using an atmospheric general circulation model (AGCM) is performed by imposing 12 different ENSO‐related SST anomalies exhibiting equal spatiotemporal distribution but different amplitude. Our AGCM experiments show strong nonlinearity in the WP zonal wind against the amplitude of the warm phase. In the strong (weak) El Niño state, the WP response tends to accelerate (prevent) the transition from El Niño to La Niña; however, this relationship is not applicable to the La Niña phase. The asymmetry in transitivity/persistency is found to differ in terms of their sensitivity to the ENSO amplitude; this difference is also detected in the long‐term control simulation of Geophysical Fluid Dynamics Laboratory‐Climate Model version 2.1. The long‐term variation in El Niño transitivity in this model correlates strongly with the decadal variation in the ENSO amplitude and Indo‐Pacific interbasin coupling. However, this result is not apparent in the opposite phase. The results of this study indicate that the decadal change in ENSO amplitude and Indian Ocean feedback could be significantly related to the decadal change in the cyclic nature of ENSO and should be discussed separately for El Niño and La Niña. Copyright © 2012 Royal Meteorological Society
Effects of an exogenous xylanase gene expression on the growth of transgenic rice and the expression level of endogenous xylanase inhibitor gene RIXI
Authors: Weng Xiaoyan , Huang Yingying , Hou Chunxiao , Jiang Dean 
Published: June 2012

AbstractBACKGROUND: Xylanases have attracted considerable interest in recent years owing to their various applications in industry and agriculture. The use of transgenic plants to produce xylanases is a less expensive alternative to biotechnological programmes. The aim of this study was to elucidate whether introducing a foreign xylanase gene ATX into rice had any adverse effect on plant growth and development.RESULTS: A recombinant xylanase gene ATX was introduced into rice variety Zhonghua 11 through Agrobacterium‐mediated transformation. The T2 generation of transgenic rice was compared with the control (non‐transgenic plants). Exogenous xylanase gene ATX was expressed in rice, and all examined transgenic lines exhibited xylanase activity. The transgenic lines (T2, ‘X1‐3’ and ‘X2‐5’) appeared to grow and develop normally. There were no differences in net photosynthetic rate between transgenic rice lines (‘X1‐3’ and ‘X2‐5’) and wild type (WT) rice plants at the heading/flowering stage. Xylanases are key enzymes in the degradation of plant cell walls. Cell wall composition analysis showed that that there were no changes in cell wall polysaccharides in the root apex but some alterations in leaves in transgenic rice plants. The results also showed that the expression of exogenous xylanase gene ATX in rice would increase the expression of endogenous xylanase inhibitor gene RIXI, which could play a role in plant defence. Thus the stress resistance of transgenic rice plants might be improved.CONCLUSION: Exogenous xylanase gene ATX could be successfully expressed in rice, and the exogenous protein had no apparent harmful effects on growth and development in transgenic rice plants. Copyright © 2012 Society of Chemical Industry