bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Vitamin D Receptor Gene Bat (Cca) Haplotype Impairs the Response to Pegylated-Interferon/ Ribavirin-Based Therapy in Chronic Hepatitis C Patients
Authors: Baur Katharina , Mertens Joachim C , Schmitt Johannes , Iwata Rika , Stieger Bruno , Frei Pascal , Seifert Burkhardt , Ferrari Heike A Bischoff , von Eckardstein Arnold , Müllhaupt Beat , Geier Andreas ,   the Swiss Hepatitis C Cohort Study
Published: December 2011

Background Chronic hepatitis C infection is a major cause of end-stage liver disease. Therapy outcome is influenced by 25-OH vitamin D deficiency. To further address this observation, our study investigates the impact of the vitamin D receptor ( NR1I1) haplotype and combined effects of plasma vitamin D levels in a well-described cohort of hepatitis C patients. Methods A total of 155 chronic hepatitis C patients were recruited from the Swiss Hepatitis C Cohort Study for NR1I1 genotyping and plasma 25-OH vitamin D level measurement. NR1I1 genotype data and combined effects of plasma 25-OH vitamin D level were analysed regarding therapy response (sustained virological response). Results A strong association was observed between therapy non-response and the NR1I1 CCA (bAt) haplotype consisting of rs1544410 (BsmI) C, rs7975232 (ApaI) C and rs731236 (TaqI) A alleles. Of the HCV patients carrying the CCA haplotype, 50.3% were non-responders (odds ratio [OR] 1.69, 95% CI 1.07, 2.67; P=0.028). A similar association was observed for the combinational CCCCAA genotype (OR 2.94, 95% CI 1.36, 6.37; P=0.007). The combinational CCCCAA genotype was confirmed as an independent risk factor for non-response in multivariate analysis (OR 2.50, 95% CI 1.07, 5.87; P=0.034). Analysing combined effects, a significant impact of low 25-OH vitamin D levels on sustained virological response were only seen in patients with the unfavourable NR1I1 CCA (bAt) haplotype (OR for non-SVR 3.55; 95% CI 1.005, 12.57; P=0.049). Conclusions NR1I1 vitamin D receptor polymorphisms influence response to pegylated-interferon/ribavirin-based therapy in chronic hepatitis C and exert an additive genetic predisposition to previously described low 25-OH vitamin D serum levels.
L'économie morale de la mort au XIXe siècle. Regards croisés sur la France et l'Angleterre
Authors: Trompette Pascale , Griffiths Robert Howell 
Published: December 2011

Résumé Cet article examine la façon dont, au XIX e siècle, la question des inhumations devient, en France comme en Angleterre, l’objet d’un traitement politique qui alimente une profonde refondation des économies de la mort. Il décrit tout d’abord son émergence comme « problème public », soutenant l’invention de nouvelles formes institutionnelles autour des funérailles et des cimetières. Attentive aux arguments et principes de légitimité en débat, l’analyse rend compte de la façon dont cette construction institutionnelle est traversée, dans les deux pays, par des enjeux similaires : la question des relations entre pouvoirs publics et Églises dans le traitement de la mort, l’invention des dispositifs politiques et sociaux de prise en charge de la question sociale de la pauvreté, la construction de la légitimité de l’industrie privée comme partie prenante de l’économie des funérailles. Elle montre que la distance entre les conceptions française et anglaise, qui pourrait trop immédiatement se laisser enfermer dans l’opposition binaire monopole public / marché libre, décrit une différenciation beaucoup plus subtile. Celle-ci renvoie à des formes originales de co-régulation entre les autorités publiques, les Églises, les entrepreneurs et la société civile dans la mise en œuvre d’une économie morale autour des funérailles.
The Impact of Government Debt on Growth
Authors: Checherita-Westphal Cristina , Rother Philipp 
Published: December 2011

Résumé	Nous étudions l’impact de la dette publique sur la croissance du pib par tête depuis 1970 et sur une période d’environ quarante années. L’impact de la dette sur la croissance est décrit par une relation non linéaire avec un seuil de l’ordre de 90-100% du pib au-delà duquel le ratio de la dette a un effet négatif sur le pib . Les intervalles de confiance montrent que des effets négatifs peuvent se manifester dès que le ratio de la dette devient égal à 70-80%, ce qui implique que la politique d’endettement doit devenir même plus prudente. Notre résultat est un argument supplémentaire en faveur des politiques de réduction de la dette comme une politique de soutien de la croissance à long terme.	JEL Code : H63, O40, E62
Debt Consolidation and Financial Stability
Authors: Angeloni Ignazio , Faia Ester , Winkler Roland 
Published: December 2011

Résumé Nous comparons trois politiques d’après crise de consolidation de la dette publique (réduction des dépenses, augmentation des impôts liés à la consommation ou au travail). Nous étudions les effets de ces politiques sur les variables macroéconomiques et la stabilité du système bancaire. Les politiques basées sur une taxation du travail permettent un ajustement rapide de la dette et réduisent les coûts intertemporels de la dette, mais elles accroissent les fluctuations des leviers bancaires ainsi que le risque. Les stratégies de taxation de la consommation ainsi que celles basées sur les dépenses donnent de meilleurs résultats, à peu près similaires pour chacune de ces deux options. JEL Code : E44, E47, E62.
Bacteria Staphylococcus spp. izolated from mastitis of sheep and their enterotoxigenic properties
Authors: Zigo František , Vasiľ Milan , Kadáši Marián , Elečko Juraj , Farkašová Zuzana 
Published: December 2011

In our study was followed occurrence of staphylococcal mastitis in herd of 350 sheep during one lactation season. We found, the bacteria S. schleiferi was identified in 88 from all 204 isolates. In high number were identified also S. caprae (33), S. chromogenes (21), S. aureus (19), S. epidermidis (17), respectively. Important was occurrence S. intermedius, S. simulans, S. xylosus a S. warneri, too. The Staphylococcuss spp. caused latent and subclinical forms of mastitis predominantly, showed into subacute mastitis (26.5%). Acute mastitis was determined in 7.8 %. Eight bacteria S. aureus, two S. chromogenes, and two S. epidermidis produced staphylococcal enterotoxins.
Photoluminescence properties of new poly(N‐vinylcarbazole)‐3‐methylthiophene (PVK‐3MeT) graft copolymer
Authors: Chemek M. , Massuyeau F. , Wéry J. , Hlel A. , Ayachi S. , Faulques E. , Lefrant S. , Alimi K. 
Published: December 2011

AbstractSteady‐state and time‐resolved photoluminescence (TRPL) measurements are used in order to investigate the emission properties of new graft copolymer involving poly(N‐vinylcarbazole) (PVK) and poly(3‐methylthiophene) (PMeT) named PVK‐3MeT. The photo‐generated species in PVK‐3MeT are identified as singlet intrachain excitons. Furthermore, radiative and nonradiative lifetimes have been calculated. The observed changes in the photo‐physical properties of the different condensed phases could be directly related to the nanostructure of the material. The use of PVK in the chemical synthesis allows the obtaining of a new organic material with better emission and slowly radiative recombination compared to those of polythiophenes indicating that the radiative channel is more enhanced. © 2011 Wiley Periodicals, Inc. J Appl Polym Sci, 2012
Time‐varying magnetic fields of 60 Hz at 7 mT induce DNA double‐strand breaks and activate DNA damage checkpoints without apoptosis
Authors: Kim Jiyeon , Yoon Yeojun , Yun Seungho , Park Gwan Soo , Lee Hae June , Song Kiwon 
Published: December 2011

AbstractThe potential genotoxic effect of a time‐varying magnetic field (MF) on human cells was investigated. Upon continuous exposure of human primary fibroblast and cervical cancer cells to a 60 Hz MF at 7 mT for 10–60 min, no significant change in cell viability was observed. However, deoxyribonucleic acid (DNA) double‐strand breaks (DSBs) were detected, and the DNA damage checkpoint pathway was activated in these cells without programmed cell death (called apoptosis). The exposure of human cells to a 60 Hz MF did not induce intracellular reactive oxygen species (ROS) production, suggesting that the observed DNA DSBs are not directly caused by ROS. We also compared the position and time dependency of DNA DSBs with numerical simulation of MFs. The Lorentz force and eddy currents in these experiments were numerically calculated to investigate the influence of each factor on DNA DSBs. The DNA DSBs mainly occurred at the central region, where the MF was strongest, after a 30‐min exposure. After 90 min, however, the amount of DNA DSBs increased rapidly in the outer regions, where the eddy current and Lorentz force were strong. Bioelectromagnetics 33:383–393, 2012. © 2011 Wiley Periodicals, Inc.
Solution Structure and Conformational Dynamics of Deoxyxylonucleic Acids (dXNA): An Orthogonal Nucleic Acid Candidate
Authors: Maiti Mohitosh , Siegmund Vanessa , Abramov Mikhail , Lescrinier Eveline , Rosemeyer Helmut , Froeyen Mathy , Ramaswamy Amutha , Ceulemans Arnout , Marx Andreas , Herdewijn Piet 
Published: December 2011

AbstractOrthogonal nucleic acids are chemically modified nucleic acid polymers that are unable to transfer information with natural nucleic acids and thus can be used in synthetic biology to store and transfer genetic information independently. Recently, it was proposed that xylose‐DNA (dXNA) can be considered to be a potential candidate for an orthogonal system. Herein, we present the structure in solution and conformational analysis of two self‐complementary, fully modified dXNA oligonucleotides, as determined by CD and NMR spectroscopy. These studies are the initial experimental proof of the structural orthogonality of dXNAs. In aqueous solution, dXNA duplexes predominantly form a linear ladderlike (type‐1) structure. This is the first example of a furanose nucleic acid that adopts a ladderlike structure. In the presence of salt, an equilibrium exists between two types of duplex form. The corresponding nucleoside triphosphates (dXNTPs) were synthesized and evaluated for their ability to be incorporated into a growing DNA chain by using several natural and mutant DNA polymerases. Despite the structural orthogonality of dXNA, DNA polymerase β mutant is able to incorporate the dXNTPs, showing DNA‐dependent dXNA polymerase activity.
Randomized trial of therapeutic group by teleconference
Authors: Heiney Sue P. , Underwood Sandra Millon , Tavakoli Abbas , Adams Swann Arp , Wells Linda M. , Bryant Lisa H. 
Published: December 2011

AbstractBACKGROUND:The effects of a therapeutic group by teleconference for African American women with breast cancer have not been documented, although the benefits of therapeutic groups for European women are well established. African American women with breast cancer may experience social disconnection, a sense of being cut off from partners, family, and friends because of side effects of treatment and fatalistic beliefs about cancer. A therapeutic group by teleconference may counteract these problems and improve social connection.METHODS:A randomized trial design stratified by treatment type was used. Data were collected at baseline, at the end of the intervention, and 16 weeks from baseline. Repeated‐measures, fixed‐factor analyses of covariance were used for each outcome. The between‐subject factors were group and replicate set, and the within‐subject factor was time. Physical well being and educational level differed significantly between the 2 groups at baseline and were used as covariates.RESULTS:The mixed‐model analysis of the outcome variables revealed significant changes over time for knowledge (P ≤ .001), with higher scores on knowledge observed for the control group. Group‐by‐time interactions were observed for fatalism (P = .0276), fear (P = .0163), and social connection (P = .0174) as measured by the Social Well Being subscale from the Functional Assessment of Cancer Treatment‐Breast Cancer Version. No group‐by‐time interaction was observed for social connection as measured by the Social Support Questionnaire. Social connection measured with the Social Well Being subscale improved significantly in the intervention group, whereas fatalism and fear significantly decreased.CONCLUSIONS:In this study, the authors documented the benefits of a therapeutic group by teleconference, a novel way to provide support for African American women with breast cancer. Further research should include a behavioral outcome, such as treatment adherence. Cancer 2012. © 2011 American Cancer Society.
Achievement of personalized pain goal in cancer patients referred to a supportive care clinic at a comprehensive cancer center
Authors: Dalal Shalini , Hui David , Nguyen Linh , Chacko Ray , Scott Cheryl , Roberts Lynn , Bruera Eduardo 
Published: December 2011

AbstractBACKGROUND:Cancer pain initiatives recommend using the personalized pain goal to tailor pain management. This study was conducted to examine the feasibility and stability of personalized pain goal, and how it compares to the clinical pain response criteria.METHODS:Records of 465 consecutive cancer patients seen in consultation at the Supportive Care Clinic were reviewed. Pain relief was assessed as clinical response (≥30% or ≥2 point pain reduction) and personalized pain goal response (pain ≤ personalized pain goal).RESULTS:One hundred fifty‐two (34%), 95 (21%), and 163 (37%) patients presented with mild (1‐4), moderate (5‐6), and severe (7‐10) pain, respectively. Median age (59 years), males (52%), and advanced cancer status (84%) did not differ by pain category. Median personalized pain goal at initial clinic consult was 3 (interquartile range, 2‐3), was similar across pain groups, and remained unchanged (P = .57) at follow‐up (median, 14 days). Clinical response was higher among patients with severe pain (60%) as compared with moderate (40%) and mild pain (33%, P < .001). Personalized pain goal response was higher among patients with mild pain (63%) as compared with moderate (44%) and severe pain (27%, P < .001). By using personalized pain goal response as the gold standard for pain relief, the sensitivity of clinical response was highest (98%) among patients with severe pain, but it had low specificity (54%). In patients with mild pain, clinical response was most specific for pain relief (98%), but had low sensitivity (52%).CONCLUSIONS:Personalized pain goal is a simple patient‐reported outcome for pain goals. The majority of patients were capable of stating their desired level for pain relief. The median personalized pain goal was 3, and it was highly stable at follow‐up assessment. Cancer 2012. © 2011 American Cancer Society.
Pemetrexed in the treatment of relapsed/refractory primary central nervous system lymphoma
Authors: Raizer Jeffrey J. , Rademaker Alfred , Evens Andrew M. , Rice Laurie , Schwartz Margaret , Chandler James P. , Getch Christopher C. , Tellez Claudia , Grimm Sean A. 
Published: December 2011

AbstractBACKGROUND:Despite initial treatment with high‐dose methotrexate‐based regimens, many patients with primary central nervous system lymphoma (PCNSL) relapse and die from their disease. No standard of care exists at progression or relapse, but chemotherapy and in some cases radiation are usually used. Pemetrexed is a multitargeted antifolate, similar to methotrexate, but with a broader spectrum of activity. Because methotrexate is an integral part of PCSNL treatment, the authors assessed the antitumor activity and safety of pemetrexed in recurrent PCNSL.METHODS:Patients with relapsed/refractory PCNSL were enrolled in this trial. Treatment consisted of pemetrexed 900 mg/m2 given every 3 weeks with low‐dose dexamethasone, folate, and B12 supplementation. Each cycle was 6 weeks, and follow‐up imaging was done before each new cycle. Treatment was continued until complete remission, progression, or toxicity.RESULTS:Eleven patients were treated, with a median age of 69.8 years and Karnofsky performance status of 70%; 10 of 11 patients had failed prior high‐dose methotrexate. The median number of pemetrexed cycles given was 5, with an associated overall response rate of 55% and disease control rate of 91%. The 6‐month progression‐free survival (PFS) was 45%, median PFS was 5.7 months, and median overall survival was 10.1 months. Toxicities were primarily hematologic and infectious.CONCLUSIONS:Pemetrexed has single‐agent activity in relapsed/refractory PCNSL. Toxicities were seen likely because of the higher than standard dose used. Further investigation of this agent or other multitargeted antifolates in PCNSL is warranted to determine optimal dose and efficacy in a more homogeneous population. Cancer 2012. © 2011 American Cancer Society.
Aldehyde dehydrogenase 1‐positive cells in axillary lymph node metastases after chemotherapy as a prognostic factor in patients with lymph node‐positive breast cancer
Authors: Sakakibara Masahiro , Fujimori Toshihiko , Miyoshi Tetsutaro , Nagashima Takeshi , Fujimoto Hiroshi , Suzuki Hiroshi Tiberu , Ohki Yohsuke , Fushimi Koya , Yokomizo Jissei , Nakatani Yukio , Miyazaki Masaru 
Published: December 2011

AbstractBACKGROUND:Aldehyde dehydrogenase 1 (ALDH1)‐positive cells exhibit stem‐like or progenitor ability and have been considered a clinically important diagnostic and therapeutic target in patients with breast cancer. In this study, the authors evaluated responsiveness to chemotherapy of ALDH1‐positive cells in primary and metastatic lesions and its relation to prognosis for patients with lymph node‐positive breast cancer.METHODS:In total, 115 patients who had breast cancer with cytologically confirmed lymph node metastases and who underwent surgery after neoadjuvant chemotherapy (NAC) were evaluated. By using ALDH1 immunohistochemistry in core‐needle biopsy specimens of the primary tumor, cytology samples of axillary lymph nodes before NAC, and pathologic samples of each after NAC, the clinical significance of ALDH1‐positive cell status was evaluated in primary and metastatic lesions before and after NAC.RESULTS:The presence of ALDH1‐positive cancer cells, but not ALDH1‐negative cancer cells, in primary and metastatic lesions after NAC was associated with a worse prognosis. In multivariate analysis, only ALDH1‐positive cells in metastatic lesions after NAC correlated with overall survival. The responsiveness of ALDH1‐positive cells to chemotherapy differed between primary and metastatic lesions, and the findings indicated that ALDH1‐positive cells in metastatic lesions after NAC may clinically precede those in the primary lesion.CONCLUSIONS:The responsiveness of ALDH1‐positive cells to chemotherapy in primary and metastatic lesions and its prognostic significance were clarified in patients with breast cancer. The authors concluded that ALDH1‐positive status may represent a surrogate marker as a new concept in patients with lymph node‐positive breast cancer. Cancer 2012. © 2011 American Cancer Society.
Post‐treatment (not interim) positron emission tomography‐computed tomography scan status is highly predictive of outcome in mantle cell lymphoma patients treated with R‐HyperCVAD
Authors: Mato Anthony R. , Svoboda Jakub , Feldman Tatyana , Zielonka Tania , Agress Harry , Panush David , Miller Mitchell , Toth Patrick , Lizotte Paul M. , Nasta Sunita , Goldberg Stuart , Chong Emeline , Schuster Steven , Pecora Andrew L. , Goy Andre 
Published: December 2011

AbstractBACKGROUND:Although convincing data exist regarding the prognostic utility of positron emission tomographic (PET)‐computed tomographic (CT) imaging in Hodgkin lymphoma and diffuse large B‐cell lymphoma, its prognostic utility both during treatment and immediately after treatment have not been systematically evaluated in a large mantle cell lymphoma (MCL) patient cohort to support its use in clinical practice.METHODS:The authors conducted a retrospective cohort study to examine the prognostic utility of PET‐CT imaging in a uniform MCL patient cohort undergoing dose‐intensive chemotherapy (R‐HyCVAD) in the frontline setting. The primary study endpoints were progression‐free survival (PFS) and overall survival (OS). PET‐CT images were centrally reviewed for the purposes of this study using standardized response criteria.RESULTS:Fifty‐three patients with advanced stage MCL with PET‐CT data were identified. With median follow‐up of 32 months, 3‐year PFS and OS estimates were 76% (95% confidence interval [CI], 64%‐84%) and 84% (95% CI, 72%‐90%), respectively. Interim PET‐CT status was not associated with PFS (hazard ratio [HR], 0.9; 95% CI, 0.3‐2.7; P = .8) or OS (HR, 0.6; 95% CI, 0.1‐2.9; P = .5). Post‐treatment PET‐CT status was statistically significantly associated with PFS (HR, 5.2; 95% CI, 2.0‐13.6; P = .001) and trended toward significant for OS (HR, 2.8; 95% CI, 0.8‐9.6; P = .07).CONCLUSIONS:These data do not support the prognostic utility of PET‐CT in pretreatment and interim treatment settings. A positive PET‐CT after the completion of therapy identifies a patient subset with an inferior PFS and a trend toward inferior OS. Cancer 2012;3565–3570. © 2011 American Cancer Society.
Population genomics of resource exploitation: insights from gene expression profiles of two Daphnia ecotypes fed alternate resources
Authors: Dudycha Jeffry L. , Brandon Christopher S. , Deitz Kevin C. 
Published: December 2011

AbstractConsumer–resource interactions are a central issue in evolutionary and community ecology because they play important roles in selection and population regulation. Most consumers encounter resource variation at multiple scales, and respond through phenotypic plasticity in the short term or evolutionary divergence in the long term. The key traits for these responses may influence resource acquisition, assimilation, and/or allocation. To identify relevant candidate genes, we experimentally assayed genome‐wide gene expression in pond and lake Daphnia ecotypes exposed to alternate resource environments. One was a simple, high‐quality laboratory diet, Ankistrodesmus falcatus. The other was the complex natural seston from a large lake. In temporary ponds, Daphnia generally experience high‐quality, abundant resources, whereas lakes provide low‐quality, seasonally shifting resources that are chronically limiting. For both ecotypes, we used replicate clones drawn from a number of separate populations. Fourteen genes were differentially regulated with respect to resources, including genes involved in gut processes, resource allocation, and activities with no obvious connection to resource exploitation. Three genes were differentially regulated in both ecotypes; the others may play a role in ecological divergence. Genes clearly linked to gut processes include two peritrophic matrix proteins, a Niemann–Pick type C2 gene, and a chymotrypsin. A pancreatic lipase, an epoxide hydrolase, a neuroparsin, and an UDP‐dependent glucuronyltransferase are potentially involved in resource allocation through effects on energy processing and storage or hormone pathways. We performed quantitative rt‐PCR for eight genes in independent samples of three clones of each of the two ecotypes. Though these largely confirmed observed differential regulation, some genes’ expression was highly variable among clones. Our results demonstrate the value of matching the level of biological replication in genome‐wide assays to the question, as it gave us insight into ecotype‐level responses at ecological and evolutionary scales despite substantial variation within ecotypes.
Nonenzymatic Acylative Kinetic Resolution of Racemic Amines and Related Compounds
Authors: Krasnov Victor P. , Gruzdev Dmitry A. , Levit Galina L. 
Published: December 2011

AbstractAcylative kinetic resolution of racemic amines occupies a highly important place among the methods for preparation of enantio enriched or pure amines. Nonenzymatic acylative kinetic resolution is usually carried out in the presence of chiral acyl‐transfer catalysts or under the action of chiral enantio‐ or diastereoselective resolving agents. Recently, this line of investigations has been rapidly developed and very interesting results of design and synthetic application of both new catalysts and chiral acylating agents have been obtained. This microreview summarizes the recent advances in this area.