bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mortality Associated with Priority Diseases in Flood-Affected Areas Using District Health Information System (DHIS2) During September–December 2022: Pakistan Experience
Authors: Nisar Nadia , Iqbal Zeeshan , Sartaaj Muhammad , Ikram Aamer , Javad Najma , Ali Kashif , Anjum Jahanzeb , Abbas Ranjha Muazam , Khan Mumtaz Ali , Bettani Muhammad Asif Khan , Shah Wasif , Tanveer Nida , Cleary Paul , Byers Chloe , Wilson Anne , Salman Muhammad , Aldeyab Mamoon A. 
Published: May 2024

Abstract

Objectives:
To quantify the burden of communicable diseases and characterize the most reported infections during public health emergency of floods in Pakistan.

Methods:
The study’s design is a descriptive trend analysis. The study utilized the disease data reported to District Health Information System (DHIS2) for the 12 most frequently reported priority diseases under the Integrated Disease Surveillance and Response (IDSR) system in Pakistan.

Results:
In total, there were 1,532,963 suspected cases during August to December 2022 in flood-affected districts (n = 75) across Pakistan; Sindh Province reported the highest number of cases (n = 692,673) from 23 districts, followed by Khyber Pakhtunkhwa (KP) (n = 568,682) from 17 districts, Balochistan (n = 167,215) from 32 districts, and Punjab (n = 104,393) from 3 districts. High positivity was reported for malaria (79,622/201,901; 39.4%), followed by acute diarrhea (non-cholera) (23/62; 37.1%), hepatitis A and E (47/252; 18.7%), and dengue (603/3245; 18.6%). The crude mortality rate was 11.9 per 10 000 population (1824/1,532,963 [deaths/cases]).

Conclusion:
The study identified acute respiratory infection, acute diarrhea, malaria, and skin diseases as the most prevalent diseases. This suggests that preparedness efforts and interventions targeting these diseases should be prioritized in future flood response plans. The study highlights the importance of strengthening the IDSR as a Disease Early Warning System through the implementation of the DHIS2.
Research breakdowns: A constructive critique of research practice involving grief, trauma and displaced people
Authors: Killikelly Clare , Comtesse Hannah , Lechner-Meichsner Franziska , Sam Johanna , Ogrodniczuk John S 
Published: May 2024

Abstract
Impactful research on refugee mental health is urgently needed. To mitigate the growing refugee crisis, researchers and clinicians seek to better understand the relationship between trauma, grief and post-migration factors with the aim of bringing better awareness, more resources and improved support for these communities and individuals living in host countries. As much as this is our intention, the prevailing research methods, that is, online anonymous questionnaires, used to engage refugees in mental health research are increasingly outdated and lack inclusivity and representation. With this perspective piece, we would like to highlight a growing crisis in global mental health research; the predominance of a Global North-centric approach and methodology. We use our recent research challenges and breakdowns as a learning example and possible opportunity to rebuild our research practice in a more ethical and equitable way.
Knowing Better: Motivated Ignorance and Willful Ignorance
Authors: Freedman Karyn L. 
Published: May 2024

AbstractMotivated ignorance is an incentivized absence of knowledge that arises in circumstances of unequal power relations, a self-protective non-knowing which frees individuals from having to reflect on the privileges they have in virtue of membership in a dominant social group. In philosophical discussions, the term “motivated ignorance” gets used interchangeably with “willful ignorance.” In the first half of this paper, using Charles Mills’ (2007) white ignorance as the defining case, I argue that this is a mistake. A significant swath of cases of motivated ignorance are non-willful, or deep, following Rik Peels (2010). But in all cases, benefits accrued to some in virtue of their social position are gained and maintained at the expense of harms to others. In the second half of this paper, I argue that these harms are what ground attributions of culpability in cases of motivated ignorance and drive the normative requirement that the subject know better, so long as the facts in question are ordinarily and easily knowable (in a sense to be specified). Willfulness is not a necessary condition for culpability, even if it is a sufficient one.
Validation of clinical risk tools for recurrentClostridioides difficileinfection
Authors: Boone Rachel H. , Lee Emmanuel , Petri William A. , Madden Gregory R. 
Published: May 2024

AbstractObjective:We sought to validate available tools for predicting recurrentC. difficileinfection (CDI) including recurrence risk scores (by Larrainzar-Coghen, Reveles, D’Agostino, Cobo, and Eyreet al) alongside consensus guidelines risk criteria, the leading severity score (ATLAS), and PCR cycle threshold (as marker of fecal organism burden) using electronic medical records.Design:Retrospective cohort study validating previously described tools.Setting:Tertiary care academic hospital.Patients:Hospitalized adult patients with CDI at University of Virginia Medical Center.Methods:Risk scores were calculated within ±48 hours of index CDI diagnosis using a large retrospective cohort of 1,519 inpatient infections spanning 7 years and compared using area under the receiver operating characteristic curve (AUROC) and the DeLong test. Recurrent CDI events (defined as a repeat positive test or symptom relapse within 60 days requiring retreatment) were confirmed by clinician chart review.Results:Reveleset altool achieved the highest AUROC of 0.523 (and 0.537 among a subcohort of 1,230 patients with their first occurrence of CDI), which was not substantially better than other tools including the current IDSA/SHEA C. difficile guidelines or PCR cycle threshold (AUROC: 0.564), regardless of prior infection history.Conclusions:All tools performed poorly for predicting recurrentC. difficileinfection (AUROC range: 0.488–0.564), especially among patients with a prior history of infection (AUROC range: 0.436–0.591). Future studies may benefit from considering novel biomarkers and/or higher-dimensional models that could augment or replace existing tools that underperform.
Assessment centers do not measure competencies: Why this is now beyond reasonable doubt
Authors: Dewberry Chris 
Published: May 2024

AbstractAlthough assessment centers (ACs) are usually designed to measure stable competencies (i.e., dimensions), doubt about whether or not they reliably do so has endured for 70 years. Addressing this issue in a novel way, several published Generalizability (G) theory studies have sought to isolate the multiple sources of variance in AC ratings, including variance specifically concerned with competencies. Unlike previous research, these studies can provide a definitive answer to the AC construct validity issue. In this article, the historical context for the construct validity debate is set out, and the results of four large-scale G-theory studies of ACs are reviewed. It is concluded that these studies demonstrate, beyond reasonable doubt, that ACs do not reliably measure stable competencies, but instead measure general, and exercise-related, performance. The possibility that ACs measure unstable competencies is considered, and it is suggested that evidence that they do so may reflect an artefact of typical AC design rather than a “real” effect. For ethical, individual, and organizational reasons, it is argued that the use of ACs to measure competencies can no longer be justified and should be halted.
Aportes del sitio Hangar a los modelos de dieta y distribución del guanaco en las pampas de Argentina
Authors: Álvarez María Clara , Barros María P. , Storchi Lobos Daniela , Ríos Malan Milagros , Kaufmann Cristian A. 
Published: May 2024

ResumenEn este trabajo se presentan los resultados del análisis de los restos faunísticos de Hangar, un sitio arqueológico ubicado en la región pampeana argentina. Los fechados realizados sobre huesos de guanaco sitúan cronológicamente a las ocupaciones humanas en el Holoceno tardío final, período escasamente representado en el área. Los análisis tafonómicos y estratigráficos indican que el sitio presenta complejos procesos de formación, con una baja integridad, aunque con buena resolución. Los principales procesos que afectaron a los restos fueron la bioturbación y las tareas de laboreo de la tierra. Las evidencias aportadas por Hangar muestran la explotación de distintos taxones, entre los que se destacan el guanaco, el venado de las Pampas, la vizcacha, el peludo y el ñandú. Estos datos constituyen un importante insumo para el creciente avance en el conocimiento de la subsistencia de los cazadores-recolectores que habitaron la región pampeana. En particular, los fechados-taxón obtenidos aportan nuevos datos para la discusión acerca de la retracción del guanaco en momentos tardíos en el área Interserrana bonaerense.
How not to announce changes to the Immigration Rules
Authors: Cranmer Frank 
Published: May 2024

On 4 December, the Home Secretary unveiled a new package of measures to reduce immigration – a matter of great interest to faith communities, given that some of them depend fairly heavily on clergy and lay-workers from overseas to sustain their pastoral ministries. One of the elements in his statement to the Commons was a decision to ‘increase the skilled worker earnings threshold by a third to £38,700 from next spring, in line with the median full-time wage for those kinds of jobs’ and to raise the minimum income for family visas ‘to the same threshold as the minimum salary threshold for skilled workers, which is £38,700’.1
October 2023 to January 2024
Authors: Cranmer Frank 
Published: May 2024

Probably the biggest legal news of the period under consideration was the judgment of the Supreme Court in R (AAA (Syria) & Ors) v Secretary of State for the Home Department [2023] UKSC 42, [2023] WLR 4433, in which it held unanimously that the Government's policy of sending asylum-seekers to Rwanda was unlawful. One critical issue was that under section 6 of the Human Rights Act 1998, it is unlawful for a public authority to act in a way that is incompatible with a right under the ECHR – and the Secretary of State is a public authority for that purpose.
When a doctrine is not a doctrine: understating the intersection of civil and canon law and the ‘doctrine’ of marriage in the Anglican Church of Australia
Authors: Barker Renae 
Published: May 2024

AbstractThis article explores the interpretation and application of the term ‘doctrine’ within the Anglican Church of Australia and its implications in Australian civil law, particularly anti-discrimination legislation. It examines the tension between (1) the constitutional definition in the Church's constitution and (2) broader interpretations found in General Synod resolutions. The anxiety evident in the General Synod resolutions underscores ongoing debates within the Church about same-sex marriage and relationships and the application of secular exemptions in anti-discrimination legislation. The article concludes that the civil law definition of the term ‘doctrine’ is wide enough to encompass both the Anglican Church of Australia's constitutional definition and the broader meaning found in General Synod resolutions. Nevertheless, care needs to be taken by the Church to avoid the risk of civil courts being called upon to engage in their own exegesis of scripture, and thereby come to conclusions which are at odds with the avowed beliefs of the Church.
Unified framework for the separation property in binary phase-segregation processes with singular entropy densities
Authors: Gal Ciprian G. , Poiatti Andrea 
Published: May 2024

AbstractThis paper investigates the separation property in binary phase-segregation processes modelled by Cahn-Hilliard type equations with constant mobility, singular entropy densities and different particle interactions. Under general assumptions on the entropy potential, we prove the strict separation property in both two and three-space dimensions. Namely, in 2D, we notably extend the minimal assumptions on the potential adopted so far in the literature, by only requiring a mild growth condition of its first derivative near the singular points
$\pm 1$
, without any pointwise additional assumption on its second derivative. For all cases, we provide a compact proof using De Giorgi’s iterations. In 3D, we also extend the validity of the asymptotic strict separation property to the case of fractional Cahn-Hilliard equation, as well as show the validity of the separation when the initial datum is close to an ‘energy minimizer’. Our framework offers insights into statistical factors like particle interactions, entropy choices and correlations governing separation, with broad applicability.
Double-orifice tricuspid valve: case series and literature review
Authors: Haughian Brendan T. , Khoo Nee S. , Lin Lily Q. 
Published: May 2024

AbstractThe double-orifice tricuspid valve (DOTV) is a rare lesion. We present a series of three patients encountered at the Stollery Children’s Hospital with a diagnosis of DOTV on 2D and/or 3D echocardiography. The patient’s medical records are reviewed for presentation history, investigative findings, and clinical course. We discuss the cases in the context of a complete review of all literature documenting cases of DOTV. In the majority of cases, the lesion is relatively benign, with little change in valve function over the short to medium term, and outcomes are determined largely by significant concomitant heart defects.
Panic-agoraphobic symptoms in adults with ASD: the role of ruminative thinking and inflexibility
Authors: Dell’Osso Liliana , Amatori Giulia , Bonelli Chiara , Nardi Benedetta , Massimetti Enrico , Cremone Ivan Mirko , Carpita Barbara 
Published: May 2024

AbstractBackgroundScientific literature has highlighted the link between autism spectrum disorder (ASD) and anxiety disorders, but few studies have delved into the relationship between ASD and panic-agoraphobic disorders. The aim of this study is to investigate the relationship between autism spectrum and panic-agoraphobic symptoms, examining whether and which autistic domains are predictive of the presence of specific panic-agoraphobic symptoms.Materials and methodsForty-five adult subjects with ASD and 50 healthy controls (HCs) were evaluated through the Structured Clinical Interview for DSM-5, Research Version and assessed with the Adult Autism Subthreshold Spectrum (AdAS Spectrum) and the Panic-Agoraphobic – Short Version (PAS-SV) questionnaires. Statistical analyses included Mann–Whitney U test, chi-square test, and a set of linear and logistic regression analyses.ResultsThe PAS-SV total and domain scores were significantly higher in the ASD group than in the HC group. A higher AdAS total score appeared to be predictive of a higher PAS-SV total score. The AdAS domain Restricted Interests and Rumination would increase the risk of obtaining higher PAS-SV total and domain scores. Conversely, the AdAS Spectrum domain Inflexibility and Adherence to Routine would predict lower total PAS-SV score.ConclusionThis study revealed a greater representation of panic-agoraphobic symptoms in adults with ASD, as well as an increased risk of showing such symptoms in the presence of significant autistic traits. Restricted interests and ruminative thinking emerged as predominant risk factors for panic-agoraphobic manifestations.
General practitioner preferences for telehealth consultations in Australia: a pilot survey and discrete choice experiment
Authors: De Guzman Keshia R. , Smith Anthony C. , Snoswell Centaine L. 
Published: May 2024

Abstract

Aim:
To identify and quantify general practitioner (GP) preferences related to service attributes of clinical consultations, including telehealth consultations, in Australia.

Background:
GPs have been increasingly using telehealth to deliver patient care since the onset of the 2019 coronavirus disease (COVID-19) pandemic. GP preferences for telehealth service models will play an important role in the uptake and sustainability of telehealth services post-pandemic.

Methods:
An online survey was used to ask GPs general telehealth questions and have them complete a discrete choice experiment (DCE). The DCE elicited GP preferences for various service attributes of telehealth (telephone and videoconference) consultations. The DCE investigated five service attributes, including consultation mode, consultation purpose, consultation length, quality of care and rapport, and patient co-payment. Participants were presented with eight choice sets, each containing three options to choose from. Descriptive statistics was used, and mixed logit models were used to estimate and analyse the DCE data.

Findings:
A total of 60 GPs fully completed the survey. Previous telehealth experiences impacted direct preferences towards telehealth consultations across clinical presentations, although in-person modes were generally favoured (in approximately 70% of all scenarios). The DCE results lacked statistical significance which demonstrated undiscernible differences between GP preferences for some service attributes. However, it was found that GPs prefer to provide a consultation with good quality care and rapport (P < 002). GPs would also prefer to provide care to their patients rather than decline a consultation due to consultation mode, length or purpose (P < 0.0001). Based on the findings, GPs value the ability to provide high-quality care and develop rapport during a clinical consultation. This highlights the importance of recognising value-based care for future policy reforms, to ensure continued adoption and sustainability of GP telehealth services in Australia.
Transformative process theory
Authors: Fowkes James 
Published: May 2024

Abstract
Transformative constitutionalism and process theory are generally seen as worlds apart. But they may be more compatible than we think. A transformative understanding of process is very broad, but it represents a natural extension of the line already being taken by contemporary process accounts intent on expanding the theory to fit global practice. It can help us to understand why an expansion based on and including a wider set of justiciable process concerns has proved difficult to limit. Conversely, transformative constitutionalism badly needs a better account of judicial restraint to balance its preoccupation with judicial boldness. Since it shares with process theory a deep concern with democracy, it can naturally draw on process accounts to understand its own limits. Democracy-seeking review, in aiming to build as well as protect democratic capacity, needs to be as concerned with restraint as intervention, depending on the context. Working out a transformative process theory is therefore at least an exercise instructive to either side, and it can offer a way to overcome divides that hamper global engagement with these core constitutional issues.
Entangled photon pair generation in an integrated SiC platform
Authors: Rahmouni Anouar , Wang Ruixuan , Li Jingwei , Tang Xiao , Gerrits Thomas , Slattery Oliver , Li Qing , Ma Lijun 
Published: May 2024

AbstractEntanglement plays a vital role in quantum information processing. Owing to its unique material properties, silicon carbide recently emerged as a promising candidate for the scalable implementation of advanced quantum information processing capabilities. To date, however, only entanglement of nuclear spins has been reported in silicon carbide, while an entangled photon source, whether it is based on bulk or chip-scale technologies, has remained elusive. Here, we report the demonstration of an entangled photon source in an integrated silicon carbide platform for the first time. Specifically, strongly correlated photon pairs are efficiently generated at the telecom C-band wavelength through implementing spontaneous four-wave mixing in a compact microring resonator in the 4H-silicon-carbide-on-insulator platform. The maximum coincidence-to-accidental ratio exceeds 600 at a pump power of 0.17 mW, corresponding to a pair generation rate of (9 ± 1) × 103 pairs/s. Energy-time entanglement is created and verified for such signal-idler photon pairs, with the two-photon interference fringes exhibiting a visibility larger than 99%. The heralded single-photon properties are also measured, with the heralded g(2)(0) on the order of 10−3, demonstrating the SiC platform as a prospective fully integrated, complementary metal-oxide-semiconductor compatible single-photon source for quantum applications.
Resolvin E1 improves efferocytosis and rescues severe aplastic anemia in mice
Authors: Grazda Rachel , Seyfried Allison N. , Maddipati Krishna Rao , Fredman Gabrielle , MacNamara Katherine C. 
Published: May 2024

AbstractSevere aplastic anemia (SAA) is a rare, fatal disease characterized by severe cytopenias and loss of hematopoietic stem cells (HSCs). Immune-mediated destruction and inflammation are known drivers of SAA, however, the underlying mechanisms driving persistent inflammation are unknown. Current treatments for SAA rely on immunosuppressive therapies or HSC transplantation, however, these treatments are not always effective. Using an established mouse model of SAA, we observed a significant increase in apoptotic cells within the bone marrow (BM) and impaired efferocytosis in SAA mice, relative to radiation controls. Single-cell transcriptomic analysis revealed heterogeneity among BM monocytes and unique populations emerged during SAA characterized by increased inflammatory signatures and significantly increased expression of Sirpa and Cd47. CD47, a “don’t eat me” signal, was increased on both live and apoptotic BM cells, concurrent with markedly increased expression of signal regulatory protein alpha (SIRPα) on monocytes. Functionally, SIRPα blockade improved cell clearance and reduced accumulation of CD47-positive apoptotic cells. Lipidomic analysis revealed a reduction in the precursors of specialized pro-resolving lipid mediators (SPMs) and increased prostaglandins in the BM during SAA, indicative of impaired inflammation resolution. Specifically, 18-HEPE, a precursor of E-series resolvins, was significantly reduced in SAA-induced mice relative to radiation controls. Treatment of SAA mice with Resolvin E1 (RvE1) improved efferocytic function, BM cellularity, platelet output, and survival. Our data suggest that impaired efferocytosis and inflammation resolution contributes to SAA progression and demonstrate that SPMs, such as RvE1, offer new and/or complementary treatments for SAA that do not rely on immune suppression.