bluuebunny/crossref_metadata_2025_split huggingface dataset:
IMAGe syndrome: Case report with a previously unreported feature and review of published literature
Authors: Balasubramanian Meena , Sprigg Alan , Johnson Diana S. 
Published: December 2010

AbstractIMAGe syndrome is a rare condition, first reported by Vilain et al., in 1999, characterized by intrauterine growth restriction, metaphyseal dysplasia, congenital adrenal hypoplasia, and genital anomalies. Patients with this condition may present shortly after birth with severe adrenal insufficiency, which can be life‐threatening if not recognized early and commenced on steroid replacement therapy. Other reported features in this condition include, hypercalciuria and/or hypercalcemia, craniosynostosis, cleft palate, and scoliosis. We report on a 7‐year‐old boy with IMAGe syndrome, who in addition to the features in the acronym also has bilateral sensorineural hearing loss which has not been reported in previously published cases of IMAGe syndrome. We discuss the clinical presentation in our patient and review the literature in this rare multisystem disorder. © 2010 Wiley‐Liss, Inc.
UBE2A deficiency syndrome: Mild to severe intellectual disability accompanied by seizures, absent speech, urogenital, and skin anomalies in male patients
Authors: de Leeuw Nicole , Bulk Saskia , Green Andrew , Jaeckle‐Santos Lane , Baker Linda A. , Zinn Andrew R. , Kleefstra Tjitske , van der Smagt Jasper J. , Vianne Morgante Angela Maria , de Vries Bert B.A. , van Bokhoven Hans , de Brouwer Arjan P.M. 
Published: December 2010

AbstractWe describe three patients with a comparable deletion encompassing SLC25A43, SLC25A5, CXorf56, UBE2A, NKRF, and two non‐coding RNA genes, U1 and LOC100303728. Moderate to severe intellectual disability (ID), psychomotor retardation, severely impaired/absent speech, seizures, and urogenital anomalies were present in all three patients. Facial dysmorphisms include ocular hypertelorism, synophrys, and a depressed nasal bridge. These clinical features overlap with those described in two patients from a family with a similar deletion at Xq24 that also includes UBE2A, and in several patients of Brazilian and Polish families with point mutations in UBE2A. Notably, all five patients with an Xq24 deletion have ventricular septal defects that are not present in patients with a point mutation, which might be attributed to the deletion of SLC25A5. Taken together, the UBE2A deficiency syndrome in male patients with a mutation in or a deletion of UBE2A is characterized by ID, absent speech, seizures, urogenital anomalies, frequently including a small penis, and skin abnormalities, which include generalized hirsutism, low posterior hairline, myxedematous appearance, widely spaced nipples, and hair whorls. Facial dysmorphisms include a wide face, a depressed nasal bridge, a large mouth with downturned corners, thin vermilion, and a short, broad neck. © 2010 Wiley‐Liss, Inc.
High carriers frequency of an apparently ancient founder mutation p.Tyr322X in the ERCC8 gene responsible for Cockayne syndrome among Christian Arabs in Northern Israel
Authors: Khayat Morad , Hardouf Hagar , Zlotogora Joel , Shalev Stavit Allon 
Published: December 2010

AbstractMost autosomal recessive diseases are rare in the general population, but in genetically isolated communities specific condition might be frequent, mainly due to founder effect. Recognition of common inherited disorders in defined populations may be effective in improving public health care. Cockayne syndrome (CS) is a rare autosomal recessive disorder common in Christian Arabs due to a p.Tyr322X mutation. Genetic screening of the p.Tyr322X mutation of the ERCC8 gene in this population documented a carrier frequency of 6.79% (95% confidence interval: 3.84–9.74%). The haplotype analysis data, as well as the high carriers frequency of CS, suggested that the Israeli Arab Christian CS mutation (p.Tyr322X) is an ancient founder mutation that may have originated in the Christian Lebanese community. As a result of this pilot study the Christian CS mutation was included in the genetic screening program offered to the Israeli Arab Christian community. © 2010 Wiley‐Liss, Inc.
Gut, bugs, and brain: Role of commensal bacteria in the control of central nervous system disease
Authors: Ochoa‐Repáraz Javier , Mielcarz Daniel W. , Begum‐ Haque Sakhina , Kasper Lloyd H. 
Published: December 2010

AbstractThe mammalian gastrointestinal track harbors a highly heterogeneous population of microbial organisms that are essential for the complete development of the immune system. The gut microbes or “microbiota,” coupled with host genetics, determine the development of both local microbial populations and the immune system to create a complex balance recently termed the “microbiome.” Alterations of the gut microbiome may lead to dysregulation of immune responses both in the gut and in distal effector immune sites such as the central nervous system (CNS). Recent findings in experimental autoimmune encephalomyelitis, an animal model of human multiple sclerosis, suggest that altering certain bacterial populations present in the gut can lead to a proinflammatory condition that may result in the development of autoimmune diseases, in particular human multiple sclerosis. In contrast, other commensal bacteria and their antigenic products, when presented in the correct context, can protect against inflammation within the CNS. Ann Neurol 2011
Long‐Term Effects of Neonatal Capsaicin Treatment on Intraepidermal Nerve Fibers and Keratinocyte Proliferation in Rat Glabrous Skin
Authors: Martínez‐Martínez Eduardo , Toscano‐Márquez Brenda , Gutiérrez‐Ospina Gabriel 
Published: December 2010

AbstractInnervation is required to preserve several aspects of skin homeostasis. Previous studies in rodents have shown that sciatic nerve transection leads to epidermal thinning and reduced keratinocyte proliferation. As the sciatic nerve is composed of sensory and motor axons, it is not clear whether skin alterations reflect motor or sensory disturbances. In this study, we used neonatal capsaicin treatment to evaluate whether sensory chemical denervation affects keratinocyte proliferation at 1, 3, and 6 months of age. Using design‐based stereological methods, we estimated the total length of intraepidermal nerve fibers (IENF) that were of peptidergic type and the number of bromodeoxyuridine‐labeled (BrdU+) nuclei in the hind paw glabrous epidermis of control and capsaicin‐treated rats. We found that the treatment decreased the total fiber length of IENF immunoreactive for both protein gene product 9.5 (PGP+) and of IENF immunoreactive for calcitonin gene‐related peptide (CGRP+). The length of PGP+ fibers decreased by 83%, 81%, and 77% and that of CGRP+ fibers decreased by 48%, 58%, and 58% at 1, 3, and 6 months, respectively. Double‐immunofluorescence staining for neural beta III tubulin and CGRP revealed that the majority of the remaining fibers in the epidermis after capsaicin treatment were of peptidergic type. The number of BrdU+ nuclei was similar in both groups. Our findings suggest that IENF present after capsaicin treatment are sufficient to maintain epidermal replacement. Anat Rec, 2010. © 2010 Wiley‐Liss, Inc.
Quantitative Three‐Dimensional Analysis of Embryonic Chick Morphogenesis Via Microcomputed Tomography
Authors: Kim Jun Sup , Min Jouha , Recknagel Andrew K. , Riccio Mark , Butcher Jonathan T. 
Published: December 2010

AbstractEmbryonic development is a remarkably complex and rapidly evolving morphogenetic process. Although many of the early patterning events have been well described, understanding the anatomical changes at later stages where clinically relevant malformations are more likely to be survivable has been limited by the lack of quantitative 3D imaging tools. Microcomputed tomography (Micro‐CT) has emerged as a powerful tool for embryonic imaging, but a quantitative analysis of organ and tissue growth has not been conducted. In this study, we present a simple method for acquiring highly detailed, quantitative 3D datasets of embryonic chicks with Micro‐CT. Embryos between 4 and 12 days (HH23 and HH40) were labeled with osmium tetroxide (OT), which revealed highly detailed soft tissue anatomy when scanned at 25 μm resolution. We demonstrate tissue boundary and inter‐tissue contrast fidelity in virtual 2D sections are quantitatively and qualitatively similar to those of histological sections. We then establish mathematical relationships for the volumetric growth of heart, limb, eye, and brain during this period of development. We show that some organs exhibit constant exponential growth (eye and heart), whereas others contained multiple phases of growth (forebrain and limb). Furthermore, we show that cardiac myocardial volumetric growth differs in a time and chamber specific manner. These results demonstrate Micro‐CT is a powerful technique for quantitative imaging of embryonic growth. The data presented here establish baselines from which to compare the effects of genetic or experimental perturbations. Quantifying subtle differences in morphogenesis is increasingly important as research focuses on localized and conditional effects. Anat Rec,, 2010. © 2010 Wiley‐Liss, Inc.
Thyroid hormones alter the adenine nucleotide hydrolysis in adult rat blood serum
Authors: Bruno Alessandra Nejar , Carneiro‐Ramos Marcela Sorelli , Buffon Andréia , Pochmann Daniela , Ricachenevsky Felipe Klein , Barreto‐Chaves Maria Luiza M. , Sarkis João José Freitas 
Published: December 2010

AbstractThe effects of ATP, ADP, and adenosine in the processes of platelet aggregation, vasodilatation, and coronary flow have been known for many years. The sequential hydrolysis of ATP to adenosine by soluble nucleotidases constitutes the main system for rapid inactivation of circulating adenine nucleotides. Thyroid disorders affect a number of biological factors including adenosine levels in different fractions. Then, we intend to investigate if the soluble nucleotidases responsible for the ATP, ADP, and AMP hydrolysis are affected by variations in the thyroid hormone levels in blood serum from adult rats. Hyperthyroidism was induced by daily intraperitoneal injections of L‐thyroxine (T4) (2.5 and 10.0 μg/100 g body weight, respectively) for 7 or 14 days. Hypothyroidism was induced by thyroidectomy and methimazole (0.05%) added to their drinking water during 7 or 14 days. The treatments efficacy was confirmed by determination of hemodynamic parameters and cardiac hypertrophy evaluation. T4 treatment predominantly inhibited, and hypothyroidism (14 days after thyroidectomy) predominantly increased the ATP, ADP, and AMP hydrolysis in rat blood serum. These results suggest that both excess and deficiency of thyroid hormones can modulate the ATP diphosphohydrolase and 5′‐nucleotidase activities in rat blood serum and consequently modulate the effects mediated by these enzymes and their products in vascular system.
Analysis of Powder Caking in Multicomponent Powders Using Atomic Force Microscopy to Examine Particle Properties
Authors: Prime D. C. , Stapley A. G. F. , Rielly C. D. , Jones J. R. , Leaper M. C. 
Published: December 2010

AbstractAtomic force microscopy has been used to study the surface properties of model spray dried powders. Phase imaging, nanoindentation and force modulation microscopy have differentiated between the different surface material properties of the particles, revealing a regular dispersion of soft, oil rich areas distributed across the particles' surface. Humidity and temperature cycling effects on the caking behavior of the particles have also been investigated, with significant morphology changes and onset of caking found to occur within relatively short periods of time.
Aspergiolides C and D: Spirocyclic Aromatic Polyketides with Potent Protein Kinase c‐Met Inhibitory Effects
Authors: Du Lin , Ai Jing , Li Dehai , Zhu Tianjiao , Wang Ying , Knauer Michael , Bruhn Torsten , Liu Hongbing , Geng Meiyu , Gu Qianqun , Bringmann Gerhard 
Published: December 2010

AbstractVariation of the cultivation conditions for Aspergillus glaucus led to the discovery of two novel spirocyclic aromatic polyketides, aspergiolides C (3) and D (4). Their constitutions were elucidated by a combination of spectroscopic methods and isotope‐labeling experiments. Aspergiolides C (3) and D (4) occur as racemic mixtures, the resolution of which was succeeded by HPLC on a chiral phase. The absolute configurations of their enantiomers were assigned online, from the peaks in the chromatogram, by a combination of HPLC‐CD and quantum chemical CD calculations. Both compounds were found to inhibit the kinase activities of the receptor tyrosine kinases (RTKs) c‐Met, Ron, and c‐Src with low‐micromolar IC50s. The enantiomers of 3 were resolved by HPLC on a chiral phase. Both enantiomers showed a comparable inhibition of the HGF‐induced autophosphorylation of c‐Met and of subsequent cell migration.
Hydrothermal Fabrication of Quasi‐One‐Dimensional Single‐Crystalline Anatase TiO2 Nanostructures on FTO Glass and Their Applications in Dye‐Sensitized Solar Cells
Authors: Liao Jin‐Yun , Lei Bing‐Xin , Wang Yu‐Fen , Liu Jun‐Min , Su Cheng‐Yong , Kuang Dai‐Bin 
Published: December 2010

AbstractOne‐dimensional and quasi‐one‐dimensional semiconductor nanostructures are desirable for dye‐sensitized solar cells (DSSCs), since they can provide direct pathways for the rapid collection of photogenerated electrons, which could improve the photovoltaic performance of the device. Quasi‐1D single‐crystalline anatase TiO2 nanostructures have been successfully prepared on transparent, conductive fluorine‐doped tin oxide (FTO) glass with a growth direction of [101] through a facile hydrothermal approach. The influences of the initial titanium n‐butoxide (TBT) concentration, hydrothermal reaction temperature, and time on the length of quasi‐1D anatase TiO2 nanostructures and on the photovoltaic performance of DSSCs have been investigated in detail. A power conversion efficiency of 5.81 % has been obtained based on the prepared TiO2 nanostructure photoelectrode 6.7 μm thick and commercial N719 dye, with a short‐circuit current density of 13.3 mA cm−2, an open‐circuit voltage of 810 mV, and a fill factor of 0.54.
ChemInform Abstract: Bixbyite‐ and Anatase‐Type Phases in the System Sc—Ta—O—N.
Authors: Stork A. , Schilling H. , Wessel C. , Wolff H. , Boerger A. , Baehtz C. , Becker K.‐D. , Dronskowski R. , Lerch M. 
Published: December 2010

AbstractIn the title system bixbyite‐type phases of general composition ScxTa1‐x(O,N)y (0.33 ≤ x ≤ 1 and 1.7 ≤ y ≤1.9), yellow colored metastable anatase‐type phases such as Sc0.1Ta0.9O1.2N0.8 or Sc0.15Ta0.85O1.3N0.7, and anosovite‐type phases ScxTa3‐xO2xN5‐2x (0 ≤ x ≤ 1.05) are synthesized by ammonolysis of amorphous mixed oxides.
ChemInform Abstract: Crystal Structure and Physical Properties of the New Ternary Antimonides Ln3Pd8Sb4 (Ln: Y, Gd, Tb, Dy, Ho, Er, Tm).
Authors: Zelinska Mariya , Oryshchyn Stepan , Zhak Olga , Pivan Jean‐Yves , Potel Michel , Tougait Olivier , Noel Henri , Kaczorowski Dariusz 
Published: December 2010

AbstractThe title compounds are prepared by arc melting of the elements using a 2 at.% excess of Sb (700 °C, 240—360 h).
ChemInform Abstract: A Highly Effective Bis(sulfonamide)—Diamine Ligand: A Unique Chiral Skeleton for the Enantioselective Cu‐Catalyzed Henry Reaction.
Authors: Jin Wei , Li Xincheng , Huang Yongbo , Wu Fan , Wan Boshun 
Published: December 2010

AbstractNewly developed bis(sulfonamide)‐diamines are highly efficient ligands in the asymmetric copper‐catalyzed Henry reaction between nitromethane and both aliphatic and aromatic aldehydes using a low catalyst loading.
ChemInform Abstract: Solid—Liquid Phase Alkylation of N‐Heterocycles: Microwave‐Assisted Synthesis as an Environmentally Friendly Alternative.
Authors: Milen Matyas , Gruen Alajos , Balint Erika , Dancso Andras , Keglevich Gyoergy 
Published: December 2010

AbstractThe alkylation of N‐heterocycles proceeds under different conditions.
ChemInform Abstract: A New Combined Source of “CN” from N,N‐Dimethylformamide and Ammonia in the Palladium‐Catalyzed Cyanation of Aryl C—H Bonds.
Authors: Kim Jinho , Chang Sukbok 
Published: December 2010

AbstractIsotopic incorporation experiments reveal that the carbon and nitrogen of the “CN” originate from the N,N‐dimethyl moiety of DMF and ammonia, respectively.
ChemInform Abstract: (9H‐Fluoren‐9‐yl)methanesufonyl (Fms): An Amino Protecting Group Complementary to Fmoc.
Authors: Ishibashi Yoshitaka , Miyata Kengo , Kitamura Masato 
Published: December 2010

AbstractThe sulfonamide‐based protecting group Fms can be used for the protection of primary and secondary amines, α‐amino carboxylic esters, and α‐amino phosphonic esters.
ChemInform Abstract: N‐Substituted α‐Trifluoromethyl β‐Nitro Amines in the Synthesis of Fluorine‐Containing 1,2‐Diamines, Amino Alcohols, and β‐Amino Acids.
Authors: Korotaev V. Yu. , Barkov A. Yu. , Kodess M. I. , Kutyashev I. B. , Slepukhin P. A. , Zapevalov A. Ya. 
Published: December 2010

Abstractα‐Trifluoromethyl‐β‐nitroamines, e.g. (III), (IX) or (XIV)/(XV), obtained by amination of either diazo‐nitropropane (I) or nitroolefins like (XIII), represent useful building blocks that can be further functionalized by reduction of the nitro group.
ChemInform Abstract: Efficient and Economic Halogenation of Aryl Amines via Arenediazonium Tosylate Salts.
Authors: Lee Young Min , Moon Mi Eun , Vajpayee Vaishali , Filimonov Victor D. , Chi Ki‐Whan 
Published: December 2010

AbstractBromination and chlorination of various aniline substrates is carried out under optimized conditions A) and proceeds via formation of arenediazonium tosylates.
ChemInform Abstract: Metal‐Free Synthesis of N‐Cyano‐Substituted Sulfilimines and Sulfoximines.
Authors: Pandey Ankur , Bolm Carsten 
Published: December 2010

AbstractThe two‐step sequence involves sulfide imination with cyanogen amide and subsequent oxidation of the resulting sulfinylimines to yield sulfoximes under metal‐free conditions.
ChemInform Abstract: A New Odorless One‐Pot Synthesis of Thioesters and Selenoesters Promoted by Rongalite®.
Authors: Dan Weixing , Deng Hongjuan , Chen Jiuxi , Liu Miaochang , Ding Jinchang , Wu Huayue 
Published: December 2010

AbstractThe process can be applied to a broad spectrum of diaryl dichalcogenides in the presence of inexpensive Rongalite and in the absence of metal catalysts.The products, versatile intermediates in natural product synthesis, are available with excellent yields within a short reaction time.
ChemInform Abstract: A General and Special Catalyst for Suzuki—Miyaura Coupling Processes.
Authors: Tang Wenjun , et al. et al. 
Published: December 2010

AbstractA novel oxaphospholano‐fused biphenyl derivative (OPBIM) is developed as efficient ligand for Pd‐catalyzed Suzuki—Miyaura cross coupling of sterically congested aryl halides and arylboronic acids.
ChemInform Abstract: Photodecarboxylative Benzylations of Phthalimide in pH 7 Buffer: A Simple Access to 3‐Arylmethyleneisoindolin‐1‐ones.
Authors: Belluau Vincent , Noeureuil Pierre , Ratzke Elfrun , Skvortsov Aleksei , Gallagher Sonia , Motti Cherri Ann , Oelgemoeller Michael 
Published: December 2010

AbstractThe reaction is achieved in a commercially available microreactor to give the corresponding hydroxy derivatives (III) and (VII).
ChemInform Abstract: Bromotriphenylphosphonium Salt Promoted Tandem One‐Pot Cyclization to Optically Active 2‐Aryl‐1,3‐oxazolines.
Authors: Jiang Haizhen , Yuan Shijie , Wan Wen , Yang Kun , Deng Hongmei , Hao Jian 
Published: December 2010

AbstractOptically active amino alcohol (II) and aromatic/heteroaromatic acids give under optimized conditions exclusively or predominantly 2,4‐substituted oxazoles.
ChemInform Abstract: Simple and Efficient Preparation of 2,5‐Disubstituted Oxazoles via a Metal‐Free‐Catalyzed Cascade Cyclization.
Authors: Wan Changfeng , Gao Linfeng , Wang Qiang , Zhang Jintang , Wang Zhiyong 
Published: December 2010

AbstractThe iodine‐catalyzed process allows the synthesis of oxazoles (24 examples) from hydrochloride (I) and aldehydes under mild conditions.
ChemInform Abstract: γ‐Fe2O3: A Magnetic Separable Catalyst for Synthesis of 5‐Substituted 1H‐Tetrazoles from Nitriles and Sodium Azide.
Authors: Qi Gang , Dai Yong 
Published: December 2010

AbstractOptimized conditions are developed for the 1,3‐dipolar cycloaddition and the catalyst can easily be removed by a magnet for reuse.
ChemInform Abstract: An Enantioselective Claisen Rearrangement Catalyzed by N‐Heterocyclic Carbenes.
Authors: Kaeobamrung Juthanat , Mahatthananchai Jessada , Zheng Pinguan , Bode Jeffrey W. 
Published: December 2010

AbstractIn the presence of a chiral azolium salt, enols and ynals undergo a highly enantioselective annulation reaction to form enantiomerically enriched dihydropyranones via an N‐heterocyclic carbene catalyzed variant of the Claisen rearrangement.
ChemInform Abstract: Regioselective Synthesis of Benzo[c]chromen‐6‐ones by One‐Pot Cyclocondensation of 1,3‐Bis(trimethylsilyloxy)‐1,3‐butadienes with 4‐Chloro‐2‐oxo‐2H‐chromene‐3‐carbaldehyde.
Authors: Fatunsin Olumide , Iaroshenko Viktor O. , Dudkin Sergii , Mkrtchyan Satenik , Villinger Alexander , Langer Peter 
Published: December 2010

AbstractIn contrast to previously reported syntheses, the reaction allows the preparation of benzo[c]chromenones in a single step but only in moderate yields.
ChemInform Abstract: Highly Flexible Synthesis of Chiral Azacycles via Iridium‐Catalyzed Hydrogenation.
Authors: Verendel J. Johan , Zhou Taigang , Li Jia‐Qi , Paptchikhine Alexander , Lebedev Oleg , Andersson Pher G. 
Published: December 2010

AbstractA ring‐closing metathesis as a key step is used to produce a number of five‐, six‐, and seven‐membered cyclic alkenes.
ChemInform Abstract: Regioselective Synthesis and in vitro Anticancer Activity of 4‐Aza‐podophyllotoxin Derivatives Catalyzed by L‐Proline.
Authors: Shi Chunling , Wang Juxian , Chen Hui , Shi Daqing 
Published: December 2010

AbstractThe method shows several advantages such as short reaction times, simple product isolation, recycling of the catalyst, and exclusive regioselectivity of the three‐component reaction in the case of unsymmetrical amines.
ChemInform Abstract: Synthesis and Reactions of 4‐Hydroxy‐8,9,10,11‐tetrahydropyrido[3,2,1‐jk]carbazol‐6‐ones.
Authors: Stadlbauer Wolfgang , Dang Hoai Van , Berger Birgit S. 
Published: December 2010

AbstractTo study the influence of substituents at the aromatic ring concerning the cyclization reactions of tetrahydrocarbazoles, a series of tetrahydrocarbazoles with methyl‐and chloro substituents in the aromatic ring, and methyl substituents in the saturated ring, e.g.(III) and (X), is synthesized.
ChemInform Abstract: Direct Synthesis of Quinazolines Through Copper‐Catalyzed Reaction of Aniline‐Derived Benzamidines.
Authors: Ohta Yusuke , Tokimizu Yusuke , Oishi Shinya , Fujii Nobutaka , Ohno Hiroaki 
Published: December 2010

AbstractAlkynylation of the title compounds with the iodoxolone derivative (II) is followed by cyclization to produce the biologically interesting quinazoline skeleton (III) in moderate yield.
ChemInform Abstract: AuI‐Catalyzed Direct Hydroamination/Hydroarylation and Double Hydroamination of Terminal Alkynes.
Authors: Patil Nitin T. , Lakshmi Pediredla G. V. V. , Singh Vipender 
Published: December 2010

AbstractA wide range of terminal alkynes smoothly undergoes hydroamination—hydroarylation reaction in the presence of a thermally stable cationic Au catalyst to give fused dihydropyrazines (III), (V), (VII) or fused dihydroquinolines (IX), (XI).
ChemInform Abstract: Sesquiterpenoids and Other Constituents from Senecio argunensis.
Authors: Xie Wei‐Dong , Niu Yu‐Fang , Lai Peng‐Xiang , Row Kyung‐Ho 
Published: December 2010

AbstractThe title compounds (I)—(III) are isolated along with several known substances from the aerial parts of the title plant.