bluuebunny/crossref_metadata_2025_split huggingface dataset:
Influence of insomnia and its correction on the emotional state of post-stroke patients
Authors: Akavov A. N. , Korabelnikova E. A. , Umakhanova Z. R. , Baranov M. L. , Mollaeva N. R. 
Published: May 2024

Introduction. Stroke is a major cause of morbidity and mortality in various populations. Sleep disturbances are common in patients who have suffered an acute cerebral circulatory disorder, complicating the recovery of motor functions, worsening the emotional state and being associated with poorer health and quality of life in general.Aim. To investigate the impact of sleep disturbance on the emotional state of stroke patients.Materials and methods. The study included 100 people who were divided into two groups. 50 patients who had suffered an acute cerebral circulatory disorder and who suffered from insomnia formed the main group, which was divided into 2 subgroups. MG1 – main subgroup 1 (26 people), who received a course of short-term (5 sessions) cognitive-behavioural therapy for insomnia in combination with the drug Valocordin-Doxylamine 25 mg as part of complex therapy. – MG2 main subgroup 2 (24 people), who received only standard treatment of the main disease. Patients in the comparison group who underwent acute cerebral circulatory disorder without concomitant insomnia (CG, 50 people) also received only standard treatment for the primary condition. In addition to clinical examination, the Hospital Anxiety and Depression Scale (HADS), the Pittsburgh Sleep Quality Questionnaire (PSQI) and the Insomnia Severity Scale (ISI) were used to assess patients.Results. Initially, the main group had a statistically significant higher level of depression (clinically expressed depression) than the comparison group (subclinically expressed depression) (U = 54.6; p = 0.012). As a result of treatment in main subgroup 1, where insomnia was corrected, there was not only an improvement in sleep (median PSQI score before treatment 8 (6; 10) and after treatment 5 (5; 6), p = 0.022), but also a reduction in depression (HADS-D score before treatment 12 (10; 14) and after treatment 12 (10; 14)): 12 (10; 14) and post-treatment – 5 (4; 6), p = 0.022) and anxiety (HADS-A pre-treatment: 9 (7; 10) and post-treatment – 5 (4; 6), p = 0.013). In the main subgroup 2, where insomnia was not corrected, there was no improvement in sleep (PSQI before treatment 8 (6; 11) and after treatment 8 (7; 10), p = 0.433), depression (HADS-D before treatment: 9 (8; 11) and after treatment – 8 (6; 9), p = 0.171) and anxiety (HADS-A before treatment: 9 (6; 10) and after treatment – 8 (6; 9), p = 0.064) were less pronounced than in the main subgroup 1 and the comparison group (HADS-D: H (2, N = 100) = 25.73829, p = 0.016; HADS-A: H (2, N = 100) = 28.42621, p = 0.004).Conclusion. Complex therapy for stroke patients suffering from insomnia, including drug and non-drug methods of insomnia correction, increases the effectiveness of treatment by not only improving the quality of sleep, but also reducing the severity of anxiety and depression.
Emotional disturbances in postcovid syndrome structure
Authors: Mikheeva A. G. , Topuzova M. P. , Mikheeva M. G. , Alekseeva T. M. , Karonova T. L. 
Published: May 2024

In this article emotional disturbances developing in the postcovid period, their features and risk factors are reviewed, as well as sleep disorders after coronavirus infection (COVID-19). The nervous system (NS) is one of the SARS-CoV-2 main targets, which is confirmed by hypo-/anosmia, which develops in most patients during the acute period of COVID-19, and in some patients it is the first symptom. Currently, the main direct routes of coronavirus impact on the NS are considered to be hematogenous and neuronal. In addition, there is an immune-mediated effect on the NS due to the cytokine storm. After an acute period of coronavirus infection postcovoid syndrome often develops. Neurological manifestations, in particular emotional disorders, occupy a significant place in its structure. Depression, anxiety, fatigue, as well as sleep disorders bother patients most often. In dynamics, the severity of most symptoms in a certain part of patients decreases, however, according to some studies, postcovid manifestations persist or worsen for a long time. Currently, female gender and psychiatric comorbidity are most often considered risk factors for the development of postcovid emotional disorders. Despite the fact that the pandemic is officially considered over, and the acute period of COVID-19 is currently much easier than in 2020–2021, internists and neurologists are still treated by patients with newly emerged emotional disorders in the postcovid period, which underlines the continuing relevance of this problem. It is worth noting that emotional disorders in the postcovid period can develop in patients of all age groups, reducing their quality of life and workability. Public awareness, early diagnosis and initiation of treatment of these disorders will help to avoid global consequences.
Relationship of neurospecific proteins with neuroimaging and cognitive disorders in patients with obstructive sleep apnea
Authors: Rubina S. S. , Chichanovskaia L. V. , Makarova I. I. , Yusufov A. A. , Slyusar N. N. 
Published: May 2024

Aim. To evaluate the relationship of neurospecific proteins with neuroimaging and cognitive impairment in patients with OSA.Materials and methods. 65 patients were examined. Two groups of patients were distinguished: the main group – with moderate and severe OSA, the control group – without OSA. The subjects underwent anthropometry, polysomnography, magnetic resonance imaging of the brain (MRI GM), assessment of cognitive impairment. Glial fibrillar acidic protein (GFAP), antibodies to the NR2 subunit of NMDA (AT to GRIN2A), and brain-derived neurotrophic factor (BDNF) were studied by enzyme immunoassay.Results. The majority of patients with apnea were found to have pre-dementia disorders on the MMSE scale, leukoareosis, subcortical gliosis, and subarachnoid space (SP) expansion according to GMRI with a body mass index of more than 38 kg/ m2 and a neck volume of more than 45 cm. The sizes of the bodies of the lateral ventricles and 3th ventricle in patients with apnea were larger than the age hole. GFAP and BDNF levels were significantly higher in patients in the main group. Negative correlations were established between the average level of BDNF content and SP expansion and between BDNF and the body index of the lateral ventricles.Conclusion. The neuromarker GFAP has shown itself to be a predictor of nervous system damage in patients with OSA. The most representative marker of neuroplasticity in sleep apnea patients is BDNF. Despite the high chances of its increase in patients with OSA, this does not compensate for the chances of pre-dementia cognitive impairment. According to MRI GM in patients with OSA, along with vascular lesions (leukoareosis, subcortical gliosis) atrophic changes are detected.
A case of granulomatos is with polyangiitis (Wegener’s) after a patient’s suffering from a new coronavirus infection COVID-19
Authors: Balaganskaya M. A. , Galkina S. N. , Teteneva A. V. , Starovoytova E. A. , Kirillova N. A. , Sorokina T. V. , Kolesnik N. Yu. , Sergeeva K. S. , Zagromova T. A. , Fedosenko S. V. 
Published: May 2024

After infection of the new coronavirus infection (NCI) COVID-19 of the patients, the development of long-term consequences can not be excluded and it is correlated not only with severe forms of the disease NCI COVID-19, but also with moderate and mild forms of th is pathology. Patients with rheumatic diseases that suffered from new coronavirus infection (NCI) COVID-19 are often encountered in doctors’ outpatient and inpatient practice. NCI can lead to an exacerbation of an existing rheumatic disease and can also be a trigger factor for autoimmune changes and the debut of a rheumatic disease. Th is article presents a clinical case of granulomatos is with polyangiitis (Wegener’s) of a patient after suffering from NCI COVID-19. The diversity of th is pathology makes its timely diagnostics quite a difficult task, oncological and septic processes, tuberculos is and rheumatological disease were excluded for a long time. Th is article reviews a long period of observation of the patient – the use of various diagnostic methods to verify the diagnosis, consultations with various specialists for differential diagnosis, and repeated changes in treatment due to periodic deterioration of the patient’s condition. Th is clinical case is a reminder to doctors, that it is extremely important to fully examine the patient and analyze the dynamics of symptoms during the therapy in details, that can highly increase the chances of earlier diagnos is of such diseases. In addition, a significant factor of improving the quality of provided medical care is the continuous education of each attending physician in order to develop interdisciplinary competencies.
Assessment of reliable wave climate at jetty on open coasts: role of 2D spatio-temporal spectrum
Authors: Basu Animesh , Purohit Anil Anant , Chavan Kumar Ashok 
Published: May 2024

ABSTRACT

The development of coastal roads and bridges is important to overcome traffic congestion in densely populated coastal cities like Mumbai. In the present study, the importance of assessment of wave conditions required for the extension of jetties to facilitate the transportation of bridge components to build the sea link bridge during non-monsoon season is envisaged so that zero downtime for operability at jetties is ascertained. A coupled hydrodynamic spectral wave model (Telemac-2D and TOMAWAC) used to hindcast waves reveals that the application of spatio-temporally varying 2D directional spectrum (from ERA-5) over the offshore boundary as a forcing function helps in propagation of a realistic wave climate of Mahim Bay, Mumbai. Coupling of the TOMAWAC-ARTEMIS model is essential to obtain reliable wave conditions near the jetties (nearshore) for predominant directions. The study reveals that under existing conditions, downtime at proposed jetties will be for 30 days wherein Hs ≥ 0.3 m. To achieve zero downtime, the existing bund on the seaward side of jetties was extended optimally (70 m) so that smooth operability for the entire non-monsoon is achieved. Thus, application of spatio-temporally varying 2D spectrum in optimising the length of the guide bund has been found promising for speedy transportation of proposed bridge components. The study also reveals that there is an insignificant climatological impact on wave conditions.
The feasibility and applicability of sequential extraction of high value-added biogenic materials from sewage sludge
Authors: Li Chen , Liu Jing , Lou Guanchen , Yu Chuning 
Published: May 2024

ABSTRACT

The sequential extraction routes of biogenic materials from sewage sludge (SS) were investigated. Physical methods (ultrasound, heating) and chemical methods (sodium hydroxide, sodium carbonate) were used to extract extracellular polymeric substances (EPS) and alginate-like extracellular polymers (ALEs) from SS. The residues after extraction were further subjected to physical methods (heating) and chemical methods (sulfuric acid, sodium hydroxide) for protein extraction. A comparison was made between sequential extraction routes and direct extraction of biomaterials from sludge in terms of extraction quantity, material properties, and applicability. The results showed that sequential extraction of biomaterials is feasible. The highest extraction quantities were obtained when using sodium carbonate for EPS and ALE extraction and sodium hydroxide for protein, reaching 449.80 mg/gVSS, 109.78 mg/gVSS, and 5447.08 mg/L, respectively. Sequential extraction procedures facilitate the extraction of biomaterials. Finally, suitable extraction methods for different application scenarios were analyzed.
Aplicabilidade da Prisão Civil do Devedor de Alimentos: Uma Análise da (in)eficácia e das Medidas Alternativas à Luz do Código de Processo Civil
Authors: De Oliveira Carmem Lucia , Rezende Gabriel Silva 
Published: May 2024

O presente artigo visa analisar a eficácia da prisão civil do devedor de alimentos que tem previsão na Constituição Federal, art. 5º LXVII, sendo a única exceção de prisão por dívida, igualmente versado ao Pacto de São José da Costa Rica, no art. 7º, item 7, fazendo-se este o modo de coerção para garantir o pagamento das prestações vencidas do alimentado. O objetivo do estudo foi analisar a efetividade real da prisão do devedor de alimentos e a utilização do artigo 139 do Código de Processo Civil.Para isso, foi utilizada, enquanto processo metodológico, a pesquisa bibliográfica, não somente de revistas científicas e artigos jurídicos, mas também de jurisprudências e doutrinas, bem como dados estatísticos do Tribunal de Justiça da Vara Única da Comarca de Miguel Pereira. A partir da análise de dados coletados, pudemos considerar que a prisão civil é ineficaz, tendo em vista que impossibilita o devedor de laborar e, consequentemente, obter renda para fornecer ao credor, dessa forma, não garantindo o pagamento da dívida. De outro modo, verificamos que a prisão civil apenas pune o alimentante, mas não é uma medida eficaz para o alimentado. Mostrando-se necessária a adoção de medidas alternativas como protesto da dívida, suspensão da CNH e passaporte, inscrição do devedor no SPC e SERASA. Tal como previsto no artigo139, IV do CPC, já que este concede ao magistrado uma liberdade de determinar quaisquer medidas que achar necessárias para assegurar o cumprimento da obrigação.
Palavras-chave: Devedor de Alimentos; Prisão Civil; Código de Processo Civil; Eficácia.
Protocolo clínico para la atención de la ofidiotoxicosis en caninos en Colombia
Authors: Herrera-Dalel Zairat Yiseth , Montoya-Forero María Paula , Zambrano-Lugo Daniel , Pedraza-Castillo Luz Natalia , Jaramillo-Hernández Dumar 
Published: May 2024

Every year, according to the World Health Organization, nearly 5,000,000 million accidents due to snake bites are reported worldwide, of which it is estimated that 33.3% to 50% of cases present as poisoning. Ophidic accidents that include ophidiotoxicosis have care protocols of therapy with antivenom serums, which vary according to the genus and species of the snake. Although in Colombia there are protocols for the care of ophidiotoxicosis in humans described by health entities, the canine clinic lacks this information. The aim of this systematic review is to build a medical protocol for ophidiotoxicosis in canines based on information reported in Colombia or tropical countries with which similar venomous snakes are shared. For this action, the PRISMA protocol was used; in total, 57 articles and 10 official documents on protocols for the care of ophidic accidents in humans were reviewed, which allowed the possible to classify snakebite accidents in group 1 (Bothrops, Lachesis and Crotalus accidents) and group 2 (Micrurus accident), also establish a medical protocol for ophidiotoxicosis in each of the groups indicated in canines, depending on the severity of the clinical and paraclinical condition. In conclusion, the clinical and paraclinical signs of the canine, vasculotoxic or neurotoxic, allow us to identify the group to which the aggressor snake belongs (group 1 or group 2, respectively), and their severity guides the selection and dosage of antivenom therapy specific for the clinical management of ophidiotoxicosis in canines.
Factores que afectan la tasa de gestación con embriones cebú producidos in vitro en trópico
Authors: Zavaleta-Martínez Alondra , Román-Fernández Orlando , Alpirez-Mendoza Manlio , Barrientos-Morales Manuel , Rodríguez-Andrade Araceli , Cervantes-Acosta Patricia , Hernández-Beltrán Antonio , Avendaño-Reyes Leonel , Dominguez-Mancera Belisario 
Published: May 2024

Objective. To study the factors affecting the success of embryo transfers (ET). Materials and methods. 1087 ET in zebu cattle were analyzed. The considered extrinsic factors of the donor cows were the cattle production unit from which they were sourced (n=13), amount of transfers in the unit (1 time, >1 time), geographical zone (n=4), period (dry or rainy) and year season; and the intrinsic factors were the breed of the bull and DC, semen, embryo quality and embryo developmental stage. Statistics were compiled with ci2 for the analysis of the main effects, and correlations were estimated through a multivariate clustering analysis. Results. The general pregnancy rate was 37.99±1.47, and there were differences (p<0.05) observed among the CPU (2.78–75%). The PR was higher in the dry than in the rainy period (44.55 vs 31.28%), and in fall and winter (p<0.05) than spring and summer (42.76, 43.98, 37.57 and 29.77%, respectively), and there were differences observed between the geographical zones as well (p<0.05). The PR was higher with excellent-quality embryos (p<0.05) than with good-quality embryos (38.9 vs. 26.3%). The period and year season had an effect over the RC (p<0.05), and the grouping analysis showed a correlation (r>0.90) between the period and year season during Oocyte pick-up (OPU) over the PR; moreover, semen, EQ and EDS had larger associations with the PR (r>0.80). Conclusions. Environmental conditions at the moment of OPU and EQ are factors worth considering in embryo transfer programs with zebu cattle using in vitro produced embryos in tropical conditions.
Classifying Self-Reported Rheumatoid Arthritis Flares Using Daily Patient-Generated Data From a Smartphone App: Exploratory Analysis Applying Machine Learning Approaches
Authors: Gandrup Julie , Selby David A , Dixon William G 
Published: May 2024

Background
The ability to predict rheumatoid arthritis (RA) flares between clinic visits based on real-time, longitudinal patient-generated data could potentially allow for timely interventions to avoid disease worsening.

Objective
This exploratory study aims to investigate the feasibility of using machine learning methods to classify self-reported RA flares based on a small data set of daily symptom data collected on a smartphone app.

Methods
Daily symptoms and weekly flares reported on the Remote Monitoring of Rheumatoid Arthritis (REMORA) smartphone app from 20 patients with RA over 3 months were used. Predictors were several summary features of the daily symptom scores (eg, pain and fatigue) collected in the week leading up to the flare question. We fitted 3 binary classifiers: logistic regression with and without elastic net regularization, a random forest, and naive Bayes. Performance was evaluated according to the area under the curve (AUC) of the receiver operating characteristic curve. For the best-performing model, we considered sensitivity and specificity for different thresholds in order to illustrate different ways in which the predictive model could behave in a clinical setting.

Results
The data comprised an average of 60.6 daily reports and 10.5 weekly reports per participant. Participants reported a median of 2 (IQR 0.75-4.25) flares each over a median follow-up time of 81 (IQR 79-82) days. AUCs were broadly similar between models, but logistic regression with elastic net regularization had the highest AUC of 0.82. At a cutoff requiring specificity to be 0.80, the corresponding sensitivity to detect flares was 0.60 for this model. The positive predictive value (PPV) in this population was 53%, and the negative predictive value (NPV) was 85%. Given the prevalence of flares, the best PPV achieved meant only around 2 of every 3 positive predictions were correct (PPV 0.65). By prioritizing a higher NPV, the model correctly predicted over 9 in every 10 non-flare weeks, but the accuracy of predicted flares fell to only 1 in 2 being correct (NPV and PPV of 0.92 and 0.51, respectively).

Conclusions
Predicting self-reported flares based on daily symptom scorings in the preceding week using machine learning methods was feasible. The observed predictive accuracy might improve as we obtain more data, and these exploratory results need to be validated in an external cohort. In the future, analysis of frequently collected patient-generated data may allow us to predict flares before they unfold, opening opportunities for just-in-time adaptative interventions. Depending on the nature and implication of an intervention, different cutoff values for an intervention decision need to be considered, as well as the level of predictive certainty required.
Các nhân tố ảnh hưởng đến ý định thực hành công nghệ thông tin xanh: bằng chứng thực nghiệm từ sinh viên Trường Đại học Cần Thơ
Authors: Ngô Mỹ Trân , Khổng Duy Thuận , Nguyễn Thị Mỹ Loan 
Published: May 2024

Nghiên cứu này được thực hiện nhằm phân tích các nhân tố ảnh hưởng đến ý định thực hành công nghệ thông tin (CNTT) xanh của sinh viên Trường Đại học Cần Thơ dựa trên mẫu nghiên cứu khảo sát từ 180 sinh viên. Các phương pháp phân tích số liệu chính được sử dụng bao gồm phương pháp phân tích nhân tố khám phá (EFA) và phân tích hồi quy nhị phân. Kết quả nghiên cứu cho thấy bốn nhân tố gồm thái độ đối với CNTT xanh, nhận thức kiểm soát hành vi, sự quan tâm đến môi trường và cân nhắc về hậu quả tương lai có ảnh hưởng tích cực đến ý định thực hành công nghệ thông tin xanh của sinh viên. Điều này cho thấy nhà trường cần hiểu rõ thái độ của sinh viên để đưa ra những kế hoạch phù hợp giúp sinh viên thấy được ý nghĩa và lợi ích của CNTT xanh. Bên cạnh đó, nhà trường cần tăng cường mở rộng việc giới thiệu về CNTT xanh cũng như tạo điều kiện cho sinh viên trải nghiệm thực hành CNTT xanh trong quá trình học tại trường.
Ảnh hưởng của các kiểu đáy khác nhau lên hiệu quả nuôi ốc hương (Babylonia areolata) thương phẩm trong hệ thống tuần hoàn
Authors: Hoàng Văn Duật , Nguyễn Đức Tú , Bùi Thị Thuỳ Nhung , Nguyễn Thế Dương , Nguyễn Tấn Sỹ 
Published: May 2024

Nghiên cứu được thực hiện nhằm xác định kiểu đáy thích hợp trong nuôi thương phẩm ốc hương (Babylonia areolata) trong hệ thống tuần hoàn. Thí nghiệm được bố trí gồm 5 nghiệm thức và được lặp lại 3 lần, diện tích mỗi bể 83,3 m2, trong 5 hệ thống tuần hoàn, cỡ ốc thả bình quân 0,2 ± 0,001 g/con; mật độ thả 2.500 con/m2: kiểu đáy không cát, giá thể nilon (NT1); kiểu đáy không cát, giá thể bông tướt (NT2); kiểu đáy 2 tầng 1 lớp cát (NT3), kiểu đáy 2 tầng 2 lớp san hô-cát (NT4) và kiểu đáy 1 tầng 2 lớp san hô-cát (NT5). Sau 176 ngày nuôi, kết quả cho thấy ốc hương nuôi trong kiểu đáy 1 tầng 2 lớp (NT5) cho kết quả tốt nhất, ốc lủi sâu trong cát và bắt mồi tốt, cỡ ốc thu 6,65 ± 0,044 g/con tốc độ tăng trưởng đạt 36,7 mg/ngày, năng suất thu 11,77 ± 0,061 kg/m2, hệ số tiêu tốn thức ăn (FCR) đạt 2,31 ± 0,012 và tỷ lệ sống đạt 70,3 ± 0,36%. Kiểu đáy NT1 và NT2 cho kết quả nuôi kém, ốc hương thường xuyên bỏ ăn, không khép nắp vỏ, tiết nhớt nhiều do không phù hợp đặc tính sinh học sống vùi mình trong cát của ốc hương.