bluuebunny/crossref_metadata_2025_split huggingface dataset:
A validated SIM GC/MS method for the simultaneous determination of dextromethorphan and its metabolites dextrorphan, 3‐methoxymorphinan and 3‐hydroxymorphinan in biological matrices and its application toin vitroCYP2D6 and CYP3A4 inhibition study
Authors: Spanakis Marios , Vizirianakis Ioannis S. , Mironidou‐Tzouveleki Maria , Niopas Ioannis 
Published: May 2009

AbstractDextromethorphan is used as a probe drug for assessing CYP2D6 and CYP3A4 activityin vivoandin vitro. A SIM GC/MS method without derivatization for the simultaneous determination of dextromethorphan and its metabolites, dextrorphan, 3‐methoxymorphinan and 3‐hydroxymorphinan, in human plasma, urine andin vitroincubation matrix was developed and validated. Calibration curves indicated good linearity with a coefficient of variation (r) better than 0.995. The lower limit of quantitation was found to be 10 ng/mL for all analytes in all matrices. Intra‐day and inter‐day precision for dextromethorphan and its metabolites was better than 9.02 and 9.91%, respectively and accuracy ranged between 91.76 and 106.27%. Recovery for dextromethorphan, its metabolites and internal standard levallorphan was greater than 72.68%. The method has been successfully applied for thein vitroinhibition of metabolism of dextromethorphan by CYP2D6 and CYP3A4 using known inhibitors of CYPs such as quinidine and verapamil. Copyright © 2009 John Wiley & Sons, Ltd.
On‐line 2D‐LC‐ESI/MS/MS determination of rifaximin in rat serum
Authors: Rao R. Nageswara , Vali R. Mastan , Shinde Dhananjay D. 
Published: May 2009

AbstractA highly sensitive and selective on‐line two‐dimensional reversed‐phase liquid chromatography/electrospray ionization–tandem mass spectrometry (2D‐LC‐ESI/MS/MS) method was developed and validated to determine rifaximin in rat serum by direct injection. The 2D‐LC‐ESI/MS/MS system consisted of a restricted access media column for trapping proteins as the first dimension and a Waters C18 column as second dimension using 0.1% aqueous acetic acid:acetonitrile as mobile phase in a gradient elution mode. Rifampacin was used as an internal standard. The linear dynamic range was 0.5–10 ng/mL (r2 > 0.998). Acceptable precision and accuracy were obtained over the calibration range. The assay was successfully used in analysis of rat serum to support pharmacokinetic studies. Copyright © 2009 John Wiley & Sons, Ltd.
An improved HPLC method for the investigation of L‐selenomethionine metabolism in rat gut contents
Authors: Krittaphol Woravimol , McDowell Arlene , Thomson Christine D. , Tucker Ian G. , Fawcett J. Paul , Mikov Momir 
Published: May 2009

AbstractSelenomethionine (SeMet) is a widely used nutritional supplement that has potential benefit for people living in selenium‐deficient areas. Previous research has shown that selenium administered as SeMet undergoes significant enterohepatic recycling which may involve the gut microflora. In order to investigate this we have developed a simple method for the quantitation of l‐SeMet in rat gut content suspensions prepared from jejunum, ileum, caecum and colon. After incubation of l‐SeMet with gut content suspensions, samples were deproteinized with sulfosalicylic acid and derivatized with o‐phthaldialdehyde (OPA) and N‐acetyl‐l‐cysteine (NAC). Mass spectrometry confirmed the formation of a 1:1:1 derivative of l‐SeMet with OPA and NAC. Samples were analysed by reversed‐phase high‐performance liquid chromatography with fluorescence detection. The assay was linear in the concentration range 0.5–100 µg/mL (r2 = 0.9992) with a limit of detection of 0.025 µg/mL (signal‐to‐noise ratio of 5). Intra‐day and inter‐day accuracies were 91.1–92.8 and 91.7–95.5%, respectively with corresponding precisions as relative standard deviation of <5%. Incubation of l‐SeMet with gut content suspensions from different parts of the rat intestine showed that l‐SeMet metabolism occurs mainly in the caecum. Copyright © 2009 John Wiley & Sons, Ltd.
Measurement of bisphenol A and bisphenol B levels in human blood sera from healthy and endometriotic women
Authors: Cobellis Luigi , Colacurci Nicola , Trabucco Elisabetta , Carpentiero Carmen , Grumetto Lucia 
Published: May 2009

AbstractA sensitive HPLC method with fluorescence detection was developed for the determination of bisphenol A (BPA) and bisphenol B (BPB) in human blood serum. The detection limits of the method were 0.18 and 0.20 ng/mL for BPA and BPB, respectively. A single‐step liquid–liquid extraction was used for the pre‐treatment of serum samples. The recoveries of BPA and BPB spiked to sera were 85.6 and 87.7%, respectively. The analyses of sera from both healthy and endometriotic women emphasized the absence of bisphenols in all the control cases (11 women), whereas BPA was found in 30 sera (51.7%) and BPB was found in 16 sera (27.6%) in the group of 58 patients with endometriosis; in nine of such sera BPA and BPB were present simultaneously. Only relatively to the sera quantitated, BPA concentrations ranged from 0.79 to 7.12 ng/mL (mean concentration 2.91 ± 1.74 ng/mL), whereas BPB concentrations ranged from 0.88 to 11.94 ng/mL (mean concentration 5.15 ± 4.16 ng/mL). Therefore, the presence of at least one of the two bisphenols was verified in a percentage as high as 63.8% in the sera from endometriotic women, suggesting the existence of a relationship between endometriosis and BPA and/or BPB exposure. Indeed, it is well known that bisphenols can work as xenoestrogens, owing to their structural similarity to natural and synthetic estrogens (e.g. estradiol and dietilstilbestrol). However, further studies are necessary to confirm this hypothesis and to assess the actual dose at which exposures to bisphenols are able to increase the sensitivity of the endometriotic cells to estradiol. Copyright © 2009 John Wiley & Sons, Ltd.
Triple‐Stem DNA Probe: A New Conformationally Constrained Probe for SNP Typing
Authors: Kolpashchikov Dmitry M. 
Published: May 2009

AbstractFinding first base: A new conformationally constrained triple‐stem DNA probe can distinguish oligonucleotides that differ by a single base over the wide temperature range from 20 to 60 °C. This demonstrates that the probe design rather than the hybridization conditions can predetermine the high specificity of nucleic acid analyte recognition. The suggested approach is a step toward multiplex SNP typing without optimization of allele‐specific hybridization assay.magnified image
Cover Picture: A Chemical Approach to Immunoprotein Engineering: Chemoselective Functionalization of Thioester Proteins in Their Native State (ChemBioChem 8/2009)
Authors: Cole Michael A. , Tully Sarah E. , Dodds Alister W. , Arnold James N. , Boldt Grant E. , Sim Robert B. , Offer John , Wentworth Paul 
Published: May 2009

AbstractThe cover picture shows chemoselective labeling of the “buried” macrocyclic thiolactone‐containing component of complement protein C3 with a variety of hydrazide probes. C3, C4, and α2‐macroglobulin play crucial roles within the complement system and as blood homeostasis regulators. Given their role in the immune system and disease, these proteins and their resulting processed fragments are highly studied, and the generation of chemically defined conjugates of these proteins offers the potential for significant advances in vaccine design and applied immunological studies. The hydrazide functionalities shown in the lower portion of this image have been used to chemoselectively label the thioester site with molecular tags, thus providing a new bioconjugation approach for thioester proteins and insight into the chemical accessibility of the thioester site. In the background of this cover image is a haystack landscape by Claude Monet representing the ability of these probes to reach these thioester “needles” within their protein scaffold and selectively label them within the complex plasma “haystack”. For further details, see the article by P. Wentworth et al. on p. 1340 ff.magnified image
Urea Route to Homoleptic Cyanates—Characterization and Luminescence Properties of [M(OCN)2(urea)] and M(OCN)2 with M=Sr, Eu
Authors: Pagano Sandro , Montana Giuseppe , Wickleder Claudia , Schnick Wolfgang 
Published: May 2009

AbstractShine a light with cyanates: A novel approach for the synthesis of urea complexes and homoleptic cyanates of alkaline earth metals and europium is described. The compounds have been fully characterized, including their magnetism and temperature‐dependent luminescence properties (see graphic).magnified imageA novel approach for the synthesis of urea complexes and homoleptic cyanates of alkaline earth metals and europium is described. Direct reaction of urea with elemental Sr or Eu in closed ampoules at temperatures above 120 °C yields [M(OCN)2(urea)] with M=Sr, Eu. According to single‐crystal X‐ray diffraction, the isotypic complexes exhibit a layer structure ([Eu(OCN)2(urea)]: P21/c, a=7.826(2), b=7.130(1), c=12.916(3) Å, β=99.76(3)°, Z=4, V=710.3(2) Å3). Furthermore, they were characterized by vibrational spectroscopy, thermal analysis, magnetic measurements, and photoluminescence studies. Thermal treatment of the compounds [M(OCN)2(urea)] to 160–240 °C affords evaporation of urea and the subsequent formation of solvent‐free homoleptic cyanates of Sr and Eu. The crystal structures of Sr(OCN)2 and Eu(OCN)2 were determined from X‐ray powder diffraction data and refined by the Rietveld method. Both compounds crystallize in the orthorhombic space group Fddd and adopt the Sr(N3)2 type structure (Sr(OCN)2: a=6.1510(4), b=11.268(1), c=11.848(1) Å, V=821.1(2) Å3; Eu(OCN)2: a=6.1514(6), b=11.2863(12), c=11.8201(12) Å, V=820.63(15) Å3). The cyanates are stable up to 450 °C. Above 500 °C β‐Sr(CN)2 and Eu2O2(CN)2 are formed. Excitation and emission spectra of [Eu(OCN)2(urea)], [Sr(OCN)2(urea)]:Eu2+, Eu(OCN)2, Sr(OCN)2:Eu2+ at different temperatures are reported. A strong green emission for all examined Eu‐containing compounds due to a 4f6 5d1–4f7 transition is observed at low temperatures. The luminescence properties are discussed in detail and are comparable to those of thiocyanates. Compared to the latter, a blue shift of the emission bands is observed due to the higher ionicity.
High‐Yield Synthesis of Uniform Star Polymers—Is Controlled Radical Polymerization Always Needed?
Authors: Gao Haifeng , Matyjaszewski Krzysztof 
Published: May 2009

AbstractStar formation: A novel and easy method is reported for the synthesis of well‐defined star polymers with high star yield by applying conventional radical copolymerization of linear macromonomer and divinyl cross‐linkers in a homogeneous solution (see figure).magnified image
ChemInform Abstract: Transparent Dense Sodium.
Authors: Ma Yanming , Eremets Mikhail , Oganov Artem R. , Xie Yu , Trojan Ivan , Medvedev Sergey , Lyakhov Andriy O. , Valle Mario , Prakapenka Vitali 
Published: May 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Structures, Phase Transitions and Microwave Dielectric Properties of the 6H Perovskites Ba3BSb2O9, B: Mg, Ca, Sr, Ba.
Authors: Ling Chris D. , Rowda Budwy , Avdeev Maxim , Pullar Robert 
Published: May 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Battery Materials for Ultrafast Charging and Discharging.
Authors: Kang Byoungwoo , Ceder Gerbrand 
Published: May 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Preparation of Monodispersed Aragonite Microspheres via a Carbonation Crystallization Pathway.
Authors: Bao Weijun , Li Huiquan , Zhang Yi 
Published: May 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Eu3Co2In15 and KM2In9 (M: Co, Ni): 3D Frameworks Based on Transition Metal Centered In9 Clusters.
Authors: Lei Xiao‐Wu , Zhong Guo‐Hua , Li Long‐Hua , Hu Chun‐Li , Li Min‐Jie , Mao Jiang‐Gao 
Published: May 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis and Crystal Structure Determination of Yttrium Ultraphosphate YP5O14.
Authors: Mbarek A. , Graia M. , Chadeyron G. , Zambon D. , Bouaziz J. , Fourati M. 
Published: May 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Structural Versatility of the ε‐SmGax Phase: X‐Ray, Electron Diffraction, and DFT Studies.
Authors: Tillard Monique , Zitoun David , Belin Claude 
Published: May 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis, Crystal Structure and Luminescent Properties of Pyrovanadates A2CaV2O7 (A: Rb, Cs).
Authors: Tarakina Nadezda V. 
Published: May 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Dual Organocatalysis: Asymmetric Allylic—Allylic Alkylation of α,α‐Dicyanoalkenes and Morita—Baylis—Hillman Carbonates.
Authors: Cui Hai‐Lei , Peng Jing , Feng Xin , Du Wei , Jiang Kun , Chen Ying‐Chun 
Published: May 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Metalated Nitriles: Internal 1,3‐Asymmetric Induction.
Authors: Fleming Fraser F. , Liu Wang 
Published: May 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Highly Diastereo‐ and Enantioselective Aldol Reactions in Common Organic Solvents Using N‐Arylprolinamides as Organocatalysts with Enhanced Acidity.
Authors: Moorthy Jarugu Narasimha , Saha Satyajit 
Published: May 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Asymmetric Conjugate Addition of Unmodified Propionaldehyde to β‐Nitrostyrenes Catalyzed by Readily Available Proline‐Based Dipeptidols.
Authors: Yang Ren‐Yong , Da Chao‐Shan , Yi Lei , Wu Feng‐Chun , Li Hong 
Published: May 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis of Novel Functionally Substituted Pyridazines and Oxazines.
Authors: Hammouda M. , Abou Zeid Z. M. , Metwally M. A. 
Published: May 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: TEMPO‐tert‐Butyl Nitrite: An Efficient Catalytic System for Aerobic Oxidation of Alcohols.
Authors: He Xijun , Shen Zhenlu , Mo Weimin , Sun Nan , Hu Baoxiang , Hu Xinquan 
Published: May 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: A Facile and Efficient Oxalyldihydrazide/Ketone‐Promoted Copper‐Catalyzed Amination of Aryl Halides in Water.
Authors: Zhu Xinhai , Su Li , Huang Liye , Chen Gong , Wang Jinlong , Song Huacan , Wan Yiqian 
Published: May 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Transition Metal—Free Amination of Aryl Halides — A Simple and Reliable Method for the Efficient and High‐Yielding Synthesis of N‐Arylated Amines.
Authors: Bolliger Jeanne L. , Frech Christian M. 
Published: May 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Titanium‐Catalyzed Hydroaminoalkylation of Alkenes by C—H Bond Activation at sp3 Centers in the α‐Position to a Nitrogen Atom.
Authors: Kubiak Raphael , Prochnow Insa , Doye Sven 
Published: May 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Copper(II)‐Catalyzed C—C Bond‐Forming Reactions of α‐Electron‐Withdrawing Group‐Substituted Ketene S,S‐Acetals with Carbonyl Compounds and a Facile Synthesis of Coumarins.
Authors: Yuan Hong‐Juan , Wang Mang , Liu Ying‐Jie , Liu Qun 
Published: May 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Enantioselective and Catalytic Method for α‐Crotylation of Aldehydes with a Kinetic Self‐Refinement of Stereochemistry.
Authors: Malkov Andrei V. , Kabeshov Mikhail A. , Barlog Maciej , Kocovsky Pavel 
Published: May 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis and C‐Alkylation of Hindered Aldehyde Enamines.
Authors: Hodgson David M. , Bray Christopher D. , Kindon Nicholas D. , Reynolds Nigel J. , Coote Steven J. , Um Joann M. , Houk K. N. 
Published: May 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis and Sulfuration of 2′‐Adamantylidene‐9‐benzonorbornenylidene.
Authors: Sugihara Yoshiaki , Kobiki Ayumi , Nakayama Juzo 
Published: May 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Selective Oxidation of Aromatic Amines to Nitro Derivatives Using Potassium Iodide‐tert‐butyl Hydroperoxide Catalytic System.
Authors: Reddy K. Rajender , Maheswari C. Uma , Venkateshwar M. , Kantam M. Lakshmi 
Published: May 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Titanium(IV)/Tridentate BINOL Derivative as Catalyst for meso‐Aziridine Ring‐Opening Reactions: High Enantioselectivity, Strong Positive Non‐Linear Effect and Structural Characterization.
Authors: Yu Rongmin , Yamashita Yasuhiro , Kobayashi Shu 
Published: May 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Reversal of Enantioselectivity Using Tethered Bisguanidine Catalysts in the Aza‐Henry Reaction.
Authors: Lovick Helena M. , Michael Forrest E. 
Published: May 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Organocatalytic Asymmetric Alkylation of Aldehydes by SN1‐Type Reaction of Alcohols.
Authors: Cozzi Pier Giorgio , Benfatti Fides , Zoli Luca 
Published: May 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.