bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Rise of Xene Hybrids
Authors: Kumar Prashant , Singh Gurwinder , Guan Xinwei , Roy Soumyabrata , Lee Jangmee , Kim In Young , Li Xiaomin , Bu Fanxing , Bahadur Rohan , Iyengar Sathvik Ajay , Yi Jiabao , Zhao Dongyuan , Ajayan Pulickel M. , Vinu Ajayan 
Published: June 2024

AbstractXenes, mono‐elemental atomic sheets, exhibit Dirac/Dirac‐like quantum behavior. When interfaced with other 2D materials such as boron nitride, transition metal dichalcogenides, and metal carbides/nitrides/carbonitrides, it enables them with unique physicochemical properties, including structural stability, desirable bandgap, efficient charge carrier injection, flexibility/breaking stress, thermal conductivity, chemical reactivity, catalytic efficiency, molecular adsorption, and wettability. For example, BN acts as an anti‐oxidative shield, MoS2 injects electrons upon laser excitation, and MXene provides mechanical flexibility. Beyond precise compositional modulations, stacking sequences, and inter‐layer coupling controlled by parameters, achieving scalability and reproducibility in hybridization is crucial for implementing these quantum materials in consumer applications. However, realizing the full potential of these hybrid materials faces challenges such as air gaps, uneven interfaces, and the formation of defects and functional groups. Advanced synthesis techniques, a deep understanding of quantum behaviors, precise control over interfacial interactions, and awareness of cross‐correlations among these factors are essential. Xene‐based hybrids show immense promise for groundbreaking applications in quantum computing, flexible electronics, energy storage, and catalysis. In this timely perspective, recent discoveries of novel Xenes and their hybrids are highlighted, emphasizing correlations among synthetic parameters, structure, properties, and applications. It is anticipated that these insights will revolutionize diverse industries and technologies.
Ferrocene‐Based Polymer Organic Cathode for Extreme Fast Charging Lithium‐Ion Batteries with Ultralong Lifespans
Authors: Yin Mengjia , Guo Kairui , Meng Junchen , Wang Yong , Gao Hui , Xue Zhigang 
Published: June 2024

AbstractTo meet the growing demand for energy storage, lithium‐ion batteries (LIBs) with fast charging capabilities has emerged as a critical technology. The electrode materials affect the rate performance significantly. Organic electrodes with structural flexibility support fast lithium‐ion transport and are considered promising candidates for fast‐charging LIBs. However, it is a challenge to create organic electrodes that can cycle steadily and reach high energy density in a few minutes. To solve this issue, accelerating the transport of electrons and lithium ions in the electrode is the key. Here, it is demonstrated that a ferrocene‐based polymer electrode (Fc‐SO3Li) can be used as a fast‐charging organic electrode for LIBs. Thanks to its molecular architecture, LIBs with Fc‐SO3Li show exceptional cycling stability (99.99% capacity retention after 10 000 cycles) and reach an energy density of 183 Wh kg−1 in 72 seconds. Moreover, the composite material through in situ polymerization with Fc‐SO3Li and 50 wt % carbon nanotube (denoted as Fc‐SO3Li‐CNT50) achieved optimized electron and ion transport pathways. After 10 000 cycles at a high current density of 50C, it delivered a high energy density of 304 Wh kg−1. This study provides valuable insights into designing cathode materials for LIBs that combine high power and ultralong cycle life.
Interfacial Biomacromolecular Engineering Toward Stable Ah‐Level Aqueous Zinc Batteries
Authors: Huang Jiangtao , Zhong Yunpeng , Fu Hongwei , Zhao Yunxiang , Li Shenglong , Xie Yiman , Zhang Hao , Lu Bingan , Chen Lina , Liang Shuquan , Zhou Jiang 
Published: June 2024

AbstractInterfacial instability within aqueous zinc batteries (AZBs) spurs technical obstacles including parasitic side reactions and dendrite failure to reach the practical application standards. Here, an interfacial engineering is showcased by employing a bio‐ derived zincophilic macromolecule as the electrolyte additive (0.037 wt%), which features a long‐chain configuration with laterally distributed hydroxyl and sulfate anion groups, and has the propensity to remodel the electric double layer of Zn anodes. Tailored Zn2+‐rich compact layer is the result of their adaptive adsorption that effectively homogenizes the interfacial concentration field, while enabling a hybrid nucleation and growth mode characterized as nuclei‐rich and space‐confined dense plating. Further resonated with curbed corrosion and by‐products, a dendrite‐free deposition morphology is achieved. Consequently, the macromolecule‐modified zinc anode delivers over 1250 times of reversible plating/stripping at a practical area capacity of 5 mAh cm−2, as well as a high zinc utilization rate of 85%. The Zn//NH4V4O10 pouch cell with the maximum capacity of 1.02 Ah can be steadily operated at 71.4 mA g−1 (0.25 C) with 98.7% capacity retained after 50 cycles, which demonstrates the scale‐up capability and highlights a “low input and high return” interfacial strategy toward practical AZBs.
Photo‐metallo‐immunotherapy: Fabricating Chromium‐Based Nanocomposites to Enhance CAR‐T Cell Infiltration and Cytotoxicity against Solid Tumors
Authors: Zou Qingshuang , Liao Ke , Li Guangchao , Huang Xin , Zheng Yongwei , Yang Gun , Luo Min , Xue Evelyn Y. , Lan Chuanqing , Wang Shuai , Shen Yao , Luo Dixian , Ng Dennis K. P. , Liu Quan 
Published: June 2024

AbstractThe infiltration and cytotoxicity of chimeric antigen receptor (CAR)‐T cells are crucial for effective elimination of solid tumors. While metallo‐immunotherapy is a promising strategy that can activate the antitumor immunity, its role in promoting CAR‐T cell therapy remains elusive. The first single‐element nanomaterial based on chromium nanoparticles (Cr NPs) for cancer photo‐metallo‐immunotherapy has been reported previously. Herein, an extended study using biodegradable polydopamine as a versatile carrier for these nanoparticles, enabling synergistic CAR‐T cell therapy, is reported. The results show that these nanocomposites with or without further encapsulation of the anticancer drug alpelisib can promote the CAR‐T cell migration and antitumor effect. Upon irradiation with near‐infrared light, they caused mild hyperthermia that can “warm” the “cold” tumor microenvironment (TME). The administration of B7‐H3 CAR‐T cells to NOD severe combined immunodeficiency gamma mice bearing a human hepatoma or PIK3CA‐mutated breast tumor can significantly inhibit the tumor growth after the induction of tumor hyperthermia by the nanocomposites and promote the secretion of serum cytokines, including IL‐2, IFN‐γ, and TNF‐α. The trivalent Cr3+ ions, which are the major degradation product of these nanocomposites, can increase the CXCL13 and CCL3 chemokine expressions to generate tertiary lymphoid structures (TLSs) in the tumor tissues, facilitating the CAR‐T cell infiltration.
Concurrent Preimplantation Genetic Testing and Competence Assessment of Human Embryos by Transcriptome Sequencing
Authors: Wang Yuqian , Li Ye , Zhu Xiaohui , Yang Ming , Liu Yujun , Wang Nan , Long Chuan , Kuo Ying , Lian Ying , Huang Jin , Jia Jialin , Wong Catherine C. L. , Yan Zhiqiang , Yan Liying , Qiao Jie 
Published: June 2024

AbstractPreimplantation genetic testing (PGT) can minimize the risk of birth defects. However, the accuracy and applicability of routine PGT is confounded by uneven genome coverage and high allele drop‐out rate from existing single‐cell whole genome amplification methods. Here, a method to diagnose genetic mutations and concurrently evaluate embryo competence by leveraging the abundant mRNA transcript copies present in trophectoderm cells is developed. The feasibility of the method is confirmed with 19 donated blastocysts. Next, the method is applied to 82 embryos from 26 families with monogenic defects for simultaneous mutation detection and competence assessment. The accuracy rate of direct mutation detection is up to 95%, which is significantly higher than DNA‐based method. Meanwhile, this approach correctly predicted seven out of eight (87.5%) embryos that failed to implant. Of six embryos that are predicted to implant successfully, four met such expectations (66.7%). Notably, this method is superior at conditions for mutation detection that are challenging when using DNA‐based PGT, such as when detecting pathogenic genes with a high de novo rate, multiple pseudogenes, or an abnormal expansion of CAG trinucleotide repeats. Taken together, this study establishes the feasibility of an RNA‐based PGT that is also informative for assessing implantation competence.
Picrasidine S Induces cGAS‐Mediated Cellular Immune Response as a Novel Vaccine Adjuvant
Authors: Ding Xiaofan , Sun Mengxue , Guo Fusheng , Qian Xinmin , Yuan Haoyu , Lou Wenjiao , Wang Qixuan , Lei Xiaoguang , Zeng Wenwen 
Published: June 2024

AbstractNew adjuvants that trigger cellular immune responses are urgently needed for the effective development of cancer and virus vaccines. Motivated by recent discoveries that show activation of type I interferon (IFN‐I) signaling boosts T cell immunity, this study proposes that targeting this pathway can be a strategic approach to identify novel vaccine adjuvants. Consequently, a comprehensive chemical screening of 6,800 small molecules is performed, which results in the discovery of the natural compound picrasidine S (PS) as an IFN‐I inducer. Further analysis reveals that PS acts as a powerful adjuvant, significantly enhancing both humoral and cellular immune responses. At the molecular level, PS initiates the activation of the cGAS‐IFN‐I pathway, leading to an enhanced T cell response. PS vaccination notably increases the population of CD8+ central memory (TCM)‐like cells and boosts the CD8+ T cell‐mediated anti‐tumor immune response. Thus, this study identifies PS as a promising candidate for developing vaccine adjuvants in cancer prevention.
Photo‐Electro‐Thermal Textiles for Scalable, High‐Performance, and Salt‐Resistant Solar‐Driven Desalination
Authors: Xu Duo , Ge Can , Chen Ze , Zhang Zhixun , Zhang Qian , Chen Tao , Gao Chong , Xu Weilin , Fang Jian 
Published: June 2024

AbstractSolar‐driven interfacial evaporation is an emerging desalination technology that can potentially relieve the freshwater scarcity issue. To obtain high and continuous evaporation rates for all‐weather, chemically engineered structural materials have been widely explored for simultaneous photothermal and electrothermal conversion. However, many previously reported fabrication processes involve poor integration and considerable energy loss. Herein, a scalable photo‐electro‐thermal textile is proposed to enable high efficiency, long‐term salt rejection, and solar‐driven desalination. Specifically, the photo‐electro‐thermal yarns with a core (commercial electric wire)‐shell (polypyrrole‐decorated Tencel) structure realize the integration of electrothermal and photothermal conversion. The wrapping eccentricity of 1.53 mm and pitch of 3 T cm−1 for the electric wire are rationally regulated to achieve a high surface temperature of over 52 °C at a 3 V DC input. As a result, exceptional and stable evaporation rates of 5.57 kg m−2 h−1 (pure water) and 4.89 kg m−2 h−1 (3.5 wt.% brine) under 1 kW m−2·radiation with a 3 V input voltage are realized. Practical application shows that the textiles can achieve high water collection of over 46 kg m−2 d−1 over the whole day of operation. The constructed photo‐electro‐thermal textile‐based evaporator provides an effective method for commercial and scalable photo‐electro‐thermal conversion to achieve high‐performance and salt‐resistant solar‐driven desalination.
Single‐Use, Metabolite Absorbing, Resonant Transducer (SMART) Culture Vessels for Label‐Free, Continuous Cell Culture Progression Monitoring
Authors: Chan Yee Jher , Dileep Dhananjay , Rothstein Samuel M. , Cochran Eric W. , Reuel Nigel F. 
Published: June 2024

AbstractSecreted metabolites are an important class of bio‐process analytical technology (PAT) targets that can correlate to cell conditions. However, current strategies for measuring metabolites are limited to discrete measurements, resulting in limited understanding and ability for feedback control strategies. Herein, a continuous metabolite monitoring strategy is demonstrated using a single‐use metabolite absorbing resonant transducer (SMART) to correlate with cell growth. Polyacrylate is shown to absorb secreted metabolites from living cells containing hydroxyl and alkenyl groups such as terpenoids, that act as a plasticizer. Upon softening, the polyacrylate irreversibly conformed into engineered voids above a resonant sensor, changing the local permittivity which is interrogated, contact‐free, with a vector network analyzer. Compared to sensing using the intrinsic permittivity of cells, the SMART approach yields a 20‐fold improvement in sensitivity. Tracking growth of many cell types such as Chinese hamster ovary, HEK293, K562, HeLa, and E. coli cells as well as perturbations in cell proliferation during drug screening assays are demonstrated. The sensor is benchmarked to show continuous measurement over six days, ability to track different growth conditions, selectivity to transducing active cell growth metabolites against other components found in the media, and feasibility to scale out for high throughput campaigns.
SETMAR Facilitates the Differentiation of Thyroid Cancer by Regulating SMARCA2‐Mediated Chromatin Remodeling
Authors: Zhang Wei , Ruan Xianhui , Huang Yue , Zhang Weiyu , Xu Guangwei , Zhao Jingzhu , Hao Jie , Qin Nan , Liu Jinjian , Su Qian , Liu Jianfeng , Tao Mei , Wang Yuqi , Wei Songfeng , Zheng Xiangqian , Gao Ming 
Published: June 2024

AbstractThyroid cancer is the most common type of endocrine cancer, and most patients have a good prognosis. However, the thyroid cancer differentiation status strongly affects patient response to conventional treatment and prognosis. Therefore, exploring the molecular mechanisms that influence the differentiation of thyroid cancer is very important for understanding the progression of this disease and improving therapeutic options. In this study, SETMAR as a key gene that affects thyroid cancer differentiation is identified. SETMAR significantly regulates the proliferation, epithelial‐mesenchymal transformation (EMT), thyroid differentiation‐related gene expression, radioactive iodine uptake, and sensitivity to MAPK inhibitor‐based redifferentiation therapies of thyroid cancer cells. Mechanistically, SETMAR methylates dimethylated H3K36 in the SMARCA2 promoter region to promote SMARCA2 transcription. SMARCA2 can bind to enhancers of the thyroid differentiation transcription factors (TTFs) PAX8, and FOXE1 to promote their expression by enhancing chromatin accessibility. Moreover, METTL3‐mediated m6A methylation of SETAMR mRNA is observed and showed that this medication can affect SETMAR expression in an IGF2BP3‐dependent manner. Finally, the METTL3‐14‐WTAP activator effectively facilitates the redifferentiation of thyroid cancer cells via the SETMAR‐SMARCA2‐TTF axis utilized. The research provides novel insights into the molecular mechanisms underlying thyroid cancer dedifferentiation and provides a new approach for therapeutically promoting redifferentiation.
Mechanism for Local‐Atomic Structure Changes in Chalcogenide‐based Threshold‐Switching Devices
Authors: Choi Minwoo , Sung Ha‐Jun , Koo Bonwon , Park Jong‐Bong , Yang Wooyoung , Kang Youngjae , Park Yongyoung , Ham Yongnam , Yun Dong‐Jin , Ahn Dongho , Yang Kiyeon , Lee Chang Seung 
Published: June 2024

AbstractThreshold‐switching devices based on amorphous chalcogenides are considered for use as selector devices in 3D crossbar memories. However, the fundamental understanding of amorphous chalcogenide is hindered owing to the complexity of the local structures and difficulties in the trap analysis of multinary compounds. Furthermore, after threshold switching, the local structures gradually evolve to more stable energy states owing to the unstable homopolar bonds. Herein, based on trap analysis, DFT simulations, and operando XPS analysis, it is determined that the threshold switching mechanism is deeply related to the charged state of Se–Se homopolar defects. A threshold switching device is demonstrated with an excellent performance through the modification of the local structure via the addition of alloying elements and investigating the time‐dependent trap evolution. The results concerning the trap dynamics of local atomic structures in threshold switching phenomena may be used to improve the design of amorphous chalcogenides.
Discovery of Antimicrobial Lysins from the “Dark Matter” of Uncharacterized Phages Using Artificial Intelligence
Authors: Zhang Yue , Li Runze , Zou Geng , Guo Yating , Wu Renwei , Zhou Yang , Chen Huanchun , Zhou Rui , Lavigne Rob , Bergen Phillip J. , Li Jian , Li Jinquan 
Published: June 2024

AbstractThe rapid rise of antibiotic resistance and slow discovery of new antibiotics have threatened global health. While novel phage lysins have emerged as potential antibacterial agents, experimental screening methods for novel lysins pose significant challenges due to the enormous workload. Here, the first unified software package, namely DeepLysin, is developed to employ artificial intelligence for mining the vast genome reservoirs (“dark matter”) for novel antibacterial phage lysins. Putative lysins are computationally screened from uncharacterized Staphylococcus aureus phages and 17 novel lysins are randomly selected for experimental validation. Seven candidates exhibit excellent in vitro antibacterial activity, with LLysSA9 exceeding that of the best‐in‐class alternative. The efficacy of LLysSA9 is further demonstrated in mouse bloodstream and wound infection models. Therefore, this study demonstrates the potential of integrating computational and experimental approaches to expedite the discovery of new antibacterial proteins for combating increasing antimicrobial resistance.
Multiplexed In Vivo Imaging with Fluorescence Lifetime‐Modulating Tags
Authors: El Hajji Lina , Lam France , Avtodeeva Maria , Benaissa Hela , Rampon Christine , Volovitch Michel , Vriz Sophie , Gautier Arnaud 
Published: June 2024

AbstractFluorescence lifetime imaging microscopy (FLIM) opens new dimensions for highly multiplexed imaging in live cells and organisms using differences in fluorescence lifetime to distinguish spectrally identical fluorescent probes. Here, a set of fluorescence‐activating and absorption‐shifting tags (FASTs) capable of modulating the fluorescence lifetime of embedded fluorogenic 4‐hydroxybenzylidene rhodanine (HBR) derivatives is described. It is shown that changes in the FAST protein sequence can vary the local environment of the chromophore and lead to significant changes in fluorescence lifetime. These fluorescence lifetime‐modulating tags enable multiplexed imaging of up to three targets in one spectral channel using a single HBR derivative in live cells and live zebrafish larvae. The combination of fluorescence lifetime multiplexing with spectral multiplexing allows to successfully image six targets in live cells, opening great prospects for multicolor fluorescence lifetime multiplexing.
Cu Embedded in Co–P Nanosheets with Super Wetting Structure for Accelerated Overall Water Splitting under Simulated Industrial Conditions
Authors: Deng Rongrong , Zhang Qibo 
Published: June 2024

AbstractThe development of advanced electrocatalysts with exceptional performance at high current densities is pivotal for reducing electric energy consumption in industrial water splitting for hydrogen production. Herein, a flexible one‐step electrodeposition approach is developed to synthesize superhydrophilic 3D flower‐like clusters of Cu–Co–P nanosheets grown in situ on nickel foam (NF). Introducing Cu into Co–P causes strong electron interactions, forming an electronic configuration favorable for the adsorption and desorption of intermediates, which significantly improves the intrinsic catalytic activity. The as‐deposited Cu–Co–P/NF display notable bifunctional catalytic activity with low overpotentials of 259 and 65 mV for the oxygen and hydrogen evolution reactions, respectively, at 10 mA cm−2. Superwetting 3D flower‐like nanostructures are conducive to the penetration of electrolytes and the rapid release of bubbles, enabling the efficient utilization of active sites and the timely release of bubble stress under high current densities. An assembled Cu–Co–P/NF(+, −) electrolyzer achieves an impressive voltage of 1.85 V at 500 mA cm−2 for water splitting and appreciable stability for over 220 h under simulated industrial conditions. This work offers an attractive strategy for regulating superaerophobic Co–P electrocatalysts for industrial water splitting, which can contribute to practical applications.
Enhanced vasorin signaling mitigates adverse cardiovascular remodeling
Authors: Wang Mingyi , McGraw Kimberly Raginski , Monticone Robert E. , Giordo Roberta , Eid Ali H. , Pintus Gianfranco 
Published: June 2024

AbstractArterial stiffening is a critical risk factor contributing to the exponential rise in age‐associated cardiovascular disease incidence. This process involves age‐induced arterial proinflammation, collagen deposition, and calcification, which collectively contribute to arterial stiffening. The primary driver of proinflammatory processes leading to collagen deposition in the arterial wall is the transforming growth factor‐beta1 (TGF‐β1) signaling. Activation of this signaling is pivotal in driving vascular extracellular remodeling, eventually leading to arterial fibrosis and calcification. Interestingly, the glycosylated protein vasorin (VASN) physically interacts with TGF‐β1, and functionally restraining its proinflammatory fibrotic signaling in arterial walls and vascular smooth muscle cells (VSMCs). Notably, as age advances, matrix metalloproteinase type II (MMP‐2) is activated, which effectively cleaves VASN protein in both arterial walls and VSMCs. This age‐associated/MMP‐2‐mediated decrease in VASN levels exacerbates TGF‐β1 activation, amplifying arterial fibrosis and calcification in the arterial wall. Importantly, TGF‐β1 is a downstream molecule of the angiotensin II (Ang II) signaling pathway in the arterial wall and VSMCs, which is modulated by VASN. Indeed, chronic administration of Ang II to young rats significantly activates MMP‐2 and diminishes the VASN expression to levels comparable to untreated older control rats. This review highlights and discusses the role played by VASN in mitigating fibrosis and calcification by alleviating TGF‐β1 activation and signaling in arterial walls and VSMCs. Understanding these molecular physical and functional interactions may pave the way for establishing VASN‐based therapeutic strategies to counteract adverse age‐associated cardiovascular remodeling, eventually reducing the risk of cardiovascular diseases.