bluuebunny/crossref_metadata_2025_split huggingface dataset:
ChemInform Abstract: Reactions of Polyfluorinated Chalcones with o‐Aminobenzenethiol and Its Zinc Salts.
Authors: Shmuilovich K. S. , Orlova N. A. , Beregovaya I. V. , Shelkovnikov V. V. 
Published: December 2011

AbstractHCl‐catalyzed reactions of polyfluorochalcones with o‐aminothiophenol afford polyfluorine‐substituted 2,3‐dihydrobenzothiazepines.
ChemInform Abstract: Functionalization of Some Benzylthioarylboronic Acids by Benzylic Lithiation of Their N‐Butyldiethanolamine Esters or Lithium(triisopropoxy)borates.
Authors: Durka Krzysztof , Klis Tomasz , Serwatowski Janusz , Wozniak Krzysztof 
Published: December 2011

AbstractNew arylboronic acids substituted in the benzylic position are synthesized by reaction of protected benzylthioarylboronic acids with various electrophiles.
ChemInform Abstract: Cobalt‐Catalyzed Conjugate Addition of Silylacetylenes to α,β‐Unsaturated Ketones.
Authors: Nishimura Takahiro , Sawano Takahiro , Ou Keiyu , Hayashi Tamio 
Published: December 2011

AbstractA variety of β‐alkynylketones (III) and (V) is prepared by a Zn‐mediated, Co‐catalyzed conjugate addition reaction of silylacetylene (II) to unsaturated ketones.
ChemInform Abstract: Cytotoxic Eunicellin‐Type Diterpenes from the Soft Coral Litophyton viscudium.
Authors: Iwagata Tetsuo , et al. et al. 
Published: December 2011

AbstractThe new isolated diterpenes (I)—(IV) exhibit cytotoxic activity against HL‐60 (IC504.2—50 μM).
ChemInform Abstract: Discovery of a New Class of HMG‐CoA Reductase Inhibitor from Polyalthia longifolia as Potential Lipid Lowering Agent.
Authors: Sashidhara Koneni V. , Singh Suriya P. , Srivastava Anuj , Puri Anju , Chhonker Yashpal S. , Bhatta Rabi S. , Shah Priyanka , Siddiqi Mohammad Imran 
Published: December 2011

AbstractBioassay‐guided fractionation of a plant material extract from the Indian tree Polyalthia longifolia var.
ChemInform Abstract: Asymmetric Syntheses of α‐Methyl γ‐Amino Acid Derivatives.
Authors: Zhu Ye , Khumsubdee Sakunchai , Schaefer Amber , Burgess Kevin 
Published: December 2011

AbstractIn the presence of IRC, allyl amines of type (I) and (IV) smoothly undergo asymmetric hydrogenation to afford title compounds like (II) and (III).
ChemInform Abstract: De novo Synthesis of Deoxy Sugar via a Wharton Rearrangement
Authors: Wang Hua‐Yu Leo , O'Doherty George A. 
Published: December 2011

AbstractA variety of new, rare deoxy sugars such as 6‐deoxyallose (IV) and 6‐deoxyfurose (VIII) are synthesized utilizing the Wharton rearrangement of epoxy ketone (I) as the key step.
ChemInform Abstract: cis‐Glycofused Benzopyran Compounds as New Amyloid‐β Peptide Ligands.
Authors: Airoldi Cristina , Cardona Francisco , Sironi Erika , Colombo Laura , Salmona Mario , Silva Artur , Nicotra Francesco , La Ferla Barbara 
Published: December 2011

AbstractA small library of novel cis‐glycofused benzopyrans (VI) is synthesized.
ChemInform Abstract: Iron(III) Chloride as an Efficient Catalyst for Stereoselective Synthesis of Glycosyl Azides and a Cocatalyst with Cu(0) for the Subsequent Click Chemistry.
Authors: Salunke Santosh B. , Babu N. Seshu , Chen Chien‐Tien 
Published: December 2011

AbstractOrganic azides are potentially explosive and corrosive compounds and should be handled with great care, although in this particular study no adverse effects occur at small‐scale reactions.
ChemInform Abstract: Selective Oxidative Debenzylation of Mono‐ and Oligosaccharides in the Presence of Azides.
Authors: Niemietz Mathaeus , Perkams Lukas , Hoffman Joanna , Eller Steffen , Unverzagt Carlo 
Published: December 2011

AbstractThe selective oxidative debenzylation using the conditions shown in the scheme are compatible with protecting groups of the ester and amide type.
ChemInform Abstract: New Phenylpropanoid‐Substituted Flavan‐3‐ols from the Leaves of Castanopsis sclerophylla.
Authors: Huang Yong‐Lin , Matsuo Yosuke , Tanaka Takashi , Kouno Isao , Li Dian‐Peng , Nonaka Gen‐ichiro 
Published: December 2011

AbstractThe chemotaxonomical study of Castanopsis species leads to the isolation of two previously unknown flavanols.
ChemInform Abstract: Cyclopenicillone (I), a Unique Cyclopentenone from the Cultures of Penicillium decumbens
Authors: Lin Sheng , Shi Ting , Chen Ke‐Yv , Zhang Zhong‐Xiao , Shan Lei , Shen Yun‐Heng , Zhang Wei‐Dong 
Published: December 2011

Abstractstructure elucidation and inhibitory effects against lipopolysaccharides‐induced nitric oxide production in macrophages
ChemInform Abstract: Isoeugenol‐Based Novel Potent Antioxidants: Synthesis and Reactivity.
Authors: Findik Esra , Ceylan Mustafa , Elmastas Mahfuz 
Published: December 2011

Abstract6 Title compounds of type (I) are prepared by a modified Friedel—Crafts alkylation and tested for their antioxidant and radical‐scavenging activities.
ChemInform Abstract: The Iron Oxides Strike Back: From Biomedical Applications to Energy Storage Devices and Photoelectrochemical Water Splitting
Authors: Tartaj Pedro , Morales Maria P. , Gonzalez‐Carreno Teresita , Veintemillas‐Verdaguer Sabino , Serna Carlos J. 
Published: December 2011

AbstractReview: 43 refs.
Stabilization of Nanoparticles in Bubble Columns – Influence of Foam Layer Height and pH Value
Authors: Weber Alfred P. , Pieper Stefanie , Koch Dagmar 
Published: December 2011

AbstractOrganische Wirkstoffnanopartikeln können mittels Rapid Expansion of Supercritical Solutions into Aqueous Solutions (RESSAS) durch Verwendung tensidhaltiger Lösungen schonend stabilisiert werden. Um den Einfluss relevanter Systemgrößen, wie Schaumschichthöhe und pH‐Wert, auf die Abscheide‐ und Stabilisierungseffizienz zu ermitteln, wurde eine Modellblasensäule eingesetzt. Es zeigte sich, dass bereits bei geringen Bauhöhen die Kombination von Transportprozessen in den aufsteigenden Blasen und in der Schaumschicht zur effizienten Abscheidung von Nanopartikeln führt, die durch die zugegebenen Tenside gut stabilisiert werden. Der pH‐Wert seinerseits beeinflusst die Eigenschaften des Schaums und darüber auch die Abscheideeffizienz.
Synthesis of Rhenium(I) Tricarbonyl Complexes with Carbohydrate‐Pendant Tridentate Ligands and Their Cellular Uptake (Eur. J. Inorg. Chem. 2/2012)
Authors: Mikata Yuji , Takahashi Kyoko , Noguchi Yuka , Naemura Masami , Ugai Anna , Itami Saori , Yasuda Keiko , Tamotsu Satoshi , Matsuo Takashi , Storr Tim 
Published: December 2011

AbstractThe cover picture shows the cellular uptake of [ReIL(CO)3]n+ (L = ligand; n = 1 or 0) complexes with carbohydrate‐pendant ligands. The ligand library includes (i) glucose/galactose as a carbohydrate, (ii) bis(2‐pyridylmethyl)amine (DPA)/bis(2‐quinolylmethyl)amine (DQA)/N‐(2‐pyridylmethyl)glycine (NPG) as the metal‐binding component, and (iii) an ethylene chain as a linker between the metal‐binding site and the O/C‐glycosides. Microscopic analysis by using the fluorescent Re complex reveals that the complex stays in the cytosol and cannot penetrate into the nucleus. Details are discussed in the article by Y. Mikata et al. on p. 217ff. magnified image
ICE‐thermochemical conversion of biomass to biofuels—process demonstration unit test results
Authors: Newport Dave , Chandran Ravi , Arcuri Kym , Whitney Sean , Leo Daniel , Freitas Shawn 
Published: December 2011

AbstractTRI has constructed and commissioned a process demonstration unit (PDU) at Durham, NC. This integrated gasification and gas to liquids biorefinery plant is designed to process 4 dry tons per day of biomass, generate, clean up, compress and condition syngas, and catalytically convert it to Fischer‐Tropsch (F‐T) liquids. The gasification system uses TRI's proprietary indirectly heated gasification technology. The synthesis reactor is designed by Emerging Fuels Technology (EFT) and utilizes their proprietary cobalt catalyst to produce fuels and waxes. The PDU gasifier has been in operation for 7500 h, the primary gas cleanup for 3100 h, and the overall system with F‐T has operated in the integrated mode for 2800 h, all on woody biomass. F‐T liquids have been produced for a total of 4000 h with 2800 h on biosyngas and 1100 h on bottled syngas. The trials have demonstrated clean syngas production with stable H2 to CO molar ratio (∼1.9), 60+% CO conversion in the first stage of F‐T and the generation of high quality, sulfur‐free, 100% renewable fuels, i.e., pure white wax and water clear, medium fraction hydrocarbon liquids. Operation of the F‐T in the second stage mode has also demonstrated up to 65% CO conversion. System configuration details are provided and test results on performance, products, and emissions are presented. © 2011 American Institute of Chemical Engineers Environ Prog, 2012
Damping multimodal subsynchronous resonance using a static var compensator controller optimized by genetic algorithm and simulated annealing
Authors: Xie Xiaorong , Jiang Qirong , Han Yingduo 
Published: December 2011

SUMMARYAn optimal subsynchronous damping control (SSDC) of static var compensator (SVC) is designed using genetic algorithm and simulated annealing, to mitigate the multimodal subsynchronous resonance of a practical multi‐machine series‐compensated transmission system. The SSDC comprises independent modal control paths, each with separate feedback gains and phase shifts, to damp various torsional modes. The control‐design task of simultaneously tuning all the control parameters for robust stabilization of multiple torsional modes under various system conditions is formulated into a constrained optimization problem, which, by using the proposed genetic algorithm and simulated annealing, is efficiently solved and the SVC‐SSDC optimized. Eigenvalue analyses on the basis of the electromagnetic system model as well as real‐time digital simulation using the DSP‐implemented controllers have been conducted on the test system to validate the proposed approach and the designed hardware SVC‐SSDC. Copyright © 2011 John Wiley & Sons, Ltd.
COUNSELOR EVALUATION of Private Trade Schools
Authors: BENSON LOREN , THOMPSON GERALD 
Published: December 2011

Recently a group of young men completed a training program for airport control tower operators. They could not obtain positions in this field because openings for individuals with this type of training are practically non‐existent in the United States.
A young girl, graduate of a rural high school, signed a contract, with a $100 down payment, which she believed would prepare her to become an airline stewardess. Another girl, in the same community, who was a little harder to “sell,” got the same contract at a substantial discount.
Still another young lady was sold a contract for a training program which was described as having thousands of satisfied graduates. Upon investigation she found that the school had yet to graduate its first pupil!
Two Occupational Abstracts
Authors: Scott Irving O. 
Published: December 2011

More samples of the abstracts of occupational literature prepared for the National Occupational Conference are here submitted for criticism and suggestion and for such use as counselors and others may find them suitable. They form a part of the project in occupational information which was described in the March 1935 issue of this magazine (page 514). A considerable number of occupations have been covered under a plan whereby the available literature on each has been carefully examined by some specially qualified person or persons, by whom an appraisal and a composite abstract of this literature have been made.Abstracts of the literature pertaining to the following occupations have already been published: Vocational Counselor (March), Plumber (March), City and County Manager (May), Automobile Mechanic (May). Others will be published in later issues of this magazine. Comments already received from readers have been of great help in planning the remainder of the series. The basic information contained in the abstracts is susceptible of a variety of uses, and the question of the best and most effective form or method of presenting the material is under careful consideration. Suggestions will be gratefully received.
Shortage of Pharmacists
Authors: BERNAYS EDWARD L. 
Published: December 2011

[Aware of the acute shortage of registered pharmacists, a group from the pharmaceutical profession and drug trades approached Edward L. Bernays, Counsel on Public Relations, for recommendations on how to overcome the difficulty. Mr. Bernays and his staff made an objective survey and submitted their findings in a 1,200‐page report. The survey was based on published material available, correspondence with thousands in the industry and the profession, personal interviews with representatives of important groups, and with key men.Those recommendations from the report which are of special significance to vocational counselors are given here. They are excerpts from a paper read by Mr. Bernays at a meeting of the American Pharmaceutical Association, Columbus, Ohio, and published in The New York State Pharmacist, October, 1943. You will note that among the recommendations is the suggestion that a study of pharmacy as a career be made by the National Vocational Guidance Association.—Ed.]
Chemically extracted acellular muscle: A new potential scaffold for spinal cord injury repair
Authors: Zhang Xiu‐Ying , Xue Hui , Liu Jia‐Mei , Chen Dong 
Published: December 2011

AbstractExtracellular matrix is the gold standard for tissue regeneration. In this study, we directly made the extracellular matrix of the tissue or organ into scaffold for spinal cord injuries, a strategy that is seldomly tried in spinal cord engineering. The aim of this study was to determine if the chemically extracted acellular muscle could be a potential scaffold for spinal cord injury. The chemically extracted acellular muscle was implanted in the lateral hemisected adult rat thoracic spinal cord. Control rats were similarly injured. After 1 and 4 weeks, scaffold integration and biocompatibility, axon sprouting, and myelination were evaluated. The chemically extracted acellular muscle scaffolds were found to be well integrated with the host tissue. Sprouting axons grew into the full length of the scaffold in a strikingly parallel and linear fashion. A few remyelinated axons were also detected in the scaffolds. The tracing results in another six rats showed that labeled fibers entered the chemically treated muscle grafts. Furthermore, there were no apparent quantitative differences in the ED‐1 and glial fibrillary acidic protein positive cells between groups. Neuron counting showed more surviving neurons in the acellular muscle treated group than those of the injured only group. Vascularization of the grafts was also confirmed. These findings clearly demonstrated that chemically extracted acellular muscle grafts provided useful biomatrices to enhance axon sprouting in the injured spinal cord. © 2011 Wiley Periodicals, Inc. J Biomed Mater Res Part A, 2012.
Effect of nanocoating with rhamnogalacturonan‐I on surface properties and osteoblasts response
Authors: Gurzawska Katarzyna , Svava Rikke , Syberg Susanne , Yihua Yu , Haugshøj Kenneth Brian , Damager Iben , Ulvskov Peter , Christensen Leif Højslet , Gotfredsen Klaus , Jørgensen Niklas Rye 
Published: December 2011

AbstractLong‐term stability of titanium implants are dependent on a variety of factors. Nanocoating with organic molecules is one of the methods used to improve osseointegration. Therefore, the aim of this study is to evaluate the in vitro effect of nanocoating with pectic rhamnogalacturonan‐I (RG‐I) on surface properties and osteoblasts response. Three different RG‐Is from apple and lupin pectins were modified and coated on amino‐functionalized tissue culture polystyrene plates (aminated TCPS). Surface properties were evaluated by scanning electron microscopy, contact angle measurement, atomic force microscopy, and X‐ray photoelectron spectroscopy. The effects of nanocoating on proliferation, matrix formation and mineralization, and expression of genes (real‐time PCR) related to osteoblast differentiation and activity were tested using human osteoblast‐like SaOS‐2 cells. It was shown that RG‐I coatings affected the surface properties. All three RG‐I induced bone matrix formation and mineralization, which was also supported by the finding that gene expression levels of alkaline phosphatase, osteocalcin, and collagen type‐1 were increased in cells cultured on the RG‐I coated surface, indicating a more differentiated osteoblastic phenotype. This makes RG‐I coating a promising and novel candidate for nanocoatings of implants. © 2011 Wiley Periodicals, Inc. J Biomed Mater Res Part A, 2012.
Bisphosphonate‐decorated lipid nanoparticles designed as drug carriers for bone diseases
Authors: Wang Guilin , Mostafa Nesrine Z. , Incani Vanessa , Kucharski Cezary , Uludağ Hasan 
Published: December 2011

AbstractA conjugate of distearoylphosphoethanolamine‐polyethylene glycol with 2‐(3‐mercaptopropylsulfanyl)‐ethyl‐1,1‐bisphosphonic acid (thiolBP) was synthesized and incorporated into micelles and liposomes to create mineral‐binding nanocarriers for therapeutic agents. The micelles and liposomes were used to encapsulate the anticancer drug doxorubicin (DOX) and a model protein lysozyme (LYZ) by using lipid film hydration (LFH) and reverse‐phase evaporation vesicle (REV) methods. The results indicated that the micelles and LFH‐derived liposomes were better at DOX loading than the REV‐derived liposomes, while the REV method was preferable for encapsulating LYZ. The affinity of the micellar and liposomal formulations to hydroxyapatite (HA) was assessed in vitro, and the results indicated that all the thiolBP‐incorporated nanocarriers had stronger HA affinity than their counterparts without thiolBP. The thiolBP‐decorated liposomes also displayed a strong binding to a collagen/HA composite scaffold in vitro. More importantly, thiolBP‐decorated liposomes gave increased retention in the collagen/HA scaffolds after subcutaneously implantation in rats. The designed liposomes were able to entrap the bone morphogenetic protein‐2 in a bioactive form, indicating that the proposed nanocarriers could deliver bioactive factors locally in mineralized scaffolds for bone tissue engineering. © 2011 Wiley Periodicals, Inc. J Biomed Mater Res Part A, 2012.
Tailored magnetic nanoparticles for optimizing magnetic fluid hyperthermia
Authors: Khandhar Amit P. , Ferguson R. Matthew , Simon Julian A. , Krishnan Kannan M. 
Published: December 2011

AbstractMagnetic Fluid Hyperthermia (MFH) is a promising approach towards adjuvant cancer therapy that is based on the localized heating of tumors using the relaxation losses of iron oxide magnetic nanoparticles (MNPs) in alternating magnetic fields (AMF). In this study, we demonstrate optimization of MFH by tailoring MNP size to an applied AMF frequency. Unlike conventional aqueous synthesis routes, we use organic synthesis routes that offer precise control over MNP size (diameter ∼10 to 25 nm), size distribution, and phase purity. Furthermore, the particles are successfully transferred to the aqueous phase using a biocompatible amphiphilic polymer, and demonstrate long‐term shelf life. A rigorous characterization protocol ensures that the water‐stable MNPs meet all the critical requirements: (1) uniform shape and monodispersity, (2) phase purity, (3) stable magnetic properties approaching that of the bulk, (4) colloidal stability, (5) substantial shelf life, and (6) pose no significant in vitro toxicity. Using a dedicated hyperthermia system, we then identified that 16 nm monodisperse MNPs (σ–0.175) respond optimally to our chosen AMF conditions (f = 373 kHz, Ho = 14 kA/m); however, with a broader size distribution (σ–0.284) the Specific Loss Power (SLP) decreases by 30%. Finally, we show that these tailored MNPs demonstrate maximum hyperthermia efficiency by reducing viability of Jurkat cells in vitro, suggesting our optimization translates truthfully to cell populations. In summary, we present a way to intrinsically optimize MFH by tailoring the MNPs to any applied AMF, a required precursor to optimize dose and time of treatment. © 2011 Wiley Periodicals, Inc. J Biomed Mater Res Part A, 2012.
Medical therapies with adult stem/progenitor cells (MSCs): A backward journey from dramatic results in vivo to the cellular and molecular explanations
Authors: Prockop Darwin J. , Oh Joo Youn 
Published: December 2011

AbstractThere is currently great interest in the use of mesenchymal stem/stromal cells (MSCs) for the therapy of many diseases of animals and humans. However, we are still left with the serious challenges in explaining the beneficial effects of the cells. Hence, it is essential to work backward from dramatic results obtained in vivo to the cellular and molecular explanations in order to discover the secrets of MSCs. This review will focus on recent data that have changed the paradigms for understanding the therapeutic potentials of MSCs. J. Cell. Biochem. 113: 1460–1469, 2012. © 2011 Wiley Periodicals, Inc.
VE‐cadherin trans‐interactions modulate Rac activation and enhancement of lung endothelial barrier by iloprost
Authors: Birukova Anna A. , Tian Yufeng , Dubrovskyi Oleksii , Zebda Noureddine , Sarich Nicolene , Tian Xinyong , Wang Yingxiao , Birukov Konstantin G. 
Published: December 2011

AbstractSmall GTPase Rac is important regulator of endothelial cell (EC) barrier enhancement by prostacyclin characterized by increased peripheral actin cytoskeleton and increased interactions between VE‐cadherin and other adherens junction (AJ) proteins. This study utilized complementary approaches including siRNA knockdown, culturing in Ca2+‐free medium, and VE‐cadherin blocking antibody to alter VE‐cadherin extracellular interactions to investigate the role of VE‐cadherin outside‐in signaling in modulation of Rac activation and EC barrier regulation by prostacyclin analog iloprost. Spatial analysis of Rac activation in pulmonary EC by FRET revealed additional spike in iloprost‐induced Rac activity at the sites of newly formed cell–cell junctions. In contrast, disruption of VE‐cadherin extracellular trans‐interactions suppressed iloprost‐activated Rac signaling and attenuated EC barrier enhancement and cytoskeletal remodeling. These inhibitory effects were associated with decreased membrane accumulation and activation of Rac‐specific guanine nucleotide exchange factors (GEFs) Tiam1 and Vav2. Conversely, plating of pulmonary EC on surfaces coated with extracellular VE‐cadherin domain further promoted iloprost‐induced Rac signaling. In the model of thrombin‐induced EC barrier recovery, blocking of VE‐cadherin trans‐interactions attenuated activation of Rac pathway during recovery phase and delayed suppression of Rho signaling and restoration of EC barrier properties. These results suggest that VE‐cadherin outside‐in signaling controls locally Rac activity stimulated by barrier protective agonists. This control is essential for maximal EC barrier enhancement and accelerated barrier recovery. J. Cell. Physiol. 227: 3405–3416, 2012. © 2011 Wiley Periodicals, Inc.