bluuebunny/crossref_metadata_2025_split huggingface dataset:
Bibliometric review of references of nursing research papers during the decade 1994–2003 in Turkey
Authors: Ergul S. , Ardahan M. , Temel A.B. , Yıldırım B.Ö. 
Published: February 2010

ERGUL, S., ARDAHAN, M., TEMEL, A.B. & YILDIRIM, B.Ö. (2010) Bibliometric review of references of nursing research papers during the decade 1994–2003 in Turkey. International Nursing Review57, 49–55Aim:  To identify important information on the state of academic nursing and the characteristics of academic nursing publications in Turkey.Methods:  The study consists of retrospective bibliometric research. The selected sample of the research consisted of six Turkish nursing journals published between 1994–2003 from a total population of ten journals. Seventy‐four issues of these six journals were included and 825 research papers were analysed. A series of classic bibliometric indexes were used.Results:  The average number of references per scientific paper is 16.19 [±standard deviation (SD) 8.56]. The changes in the number of references taken from journals over time do not show strong fluctuations but were statistically significant (P < 0.001). The average number of references per paper is 17.71 (±SD 8.09) for research papers, while it is 14.50 (±SD 8.76) for reviews. The Price's index is 23.8% and the insularity index is 31.8%.Conclusions:  The number of references used for papers has been increasing in recent years. The use of journals within references is high while the use of books is low. The Price's index tendency is decreasing. The high insularity index observed in the articles may be considered as a negative indicator of nursing journals in Turkey.
Psycho‐social factors affecting elders' maltreatment in long‐term care facilities
Authors: Natan M. Ben , Lowenstein A. , Eisikovits Z. 
Published: February 2010

Natan M.B., Lowenstein A. & Eisikovits Z. (2010) Psycho‐social Factors Affecting Elders' Maltreatment in Long‐term Care Facilities. International Nursing Review57, 113–120Aim:  To examine and analyse major variables affecting maltreatment of elderly nursing home residents. The study was based on two theoretical paradigms: the theoretical model for predicting causes of maltreatment of elderly residents developed by Pillemer, and the Theory of Reasoned Action developed by Ajzen & Fishbein.Methods:  The study employed a correlational quantitative method. The research population consisted of the staff of 22 nursing homes in Israel. Six hundred questionnaires were distributed in these facilities and 510 were completed and returned (85%). In addition, 24 questionnaires were distributed among directors of the facilities and 22 were returned (91.6%).Findings:  Slightly more than half of the staff sampled reported abuse of elderly residents over the past year, as manifested in one or more of types of maltreatment. The total number of various types of maltreatment reported was 513. About two‐thirds of the cases were incidents of neglect. Seventy per cent of respondents reported that they had been present at incidents in which another staff member abused an elderly resident in one or more types of maltreatment, and in such situations mental abuse and mental neglect were the most prevalent forms of maltreatment.Conclusion and Recommendations:  This is the first study to examine elder maltreatment in the long‐term care population of Israel. The research findings produce an expanded and improved research model investigating elder maltreatment in long‐term nursing homes.
Giving birth: the voices of Armenian women
Authors: Amoros Z.U. , Callister L.C. , Sarkisyan K. 
Published: February 2010

AMOROS Z.U., CALLISTER L.C. & SARKISYAN K. (2010) Giving birth: the voices of Armenian women. International Nursing Review57, 135–141Purpose and study design:  The purposes of this qualitative descriptive study were to describe the perceptions of Armenian childbearing women about the meaning of giving birth and to conduct an outcomes evaluation of the Erebuni Women's Wellness Center.Method:  Fifteen women who had given birth to healthy term infants during the past 8 months and who received health‐care services at the Erebuni Medical Center, Yerevan, Armenia participated in audiotaped interviews. Questions were asked about the meaning of their childbirth experience and their satisfaction with their health care.Results:  Themes included the meaning of giving birth within the Armenian sociocultural context, enriching the family perspective across generations of Armenian families and receiving supportive quality health care.Discussion and clinical implications:  This research is an example of an international collaborative work conducted with the American International Health Alliance (AIHA) who established women's wellness centres in Eastern Europe in conjunction with United States Agency for International Development. Outcomes data is very important in order to ensure the quality of health care provided. Clinical personnel found evaluative data were helpful in improving services to women and newborns. Because of dramatic socioeconomic situation in Armenia and many changes that have happened in their health care over the past 18 years, it is important to document the outcomes of AIHA partnership programmes in improving the health of childbearing women and their families. Listening to the voices of Armenian childbearing women is essential to guide health‐care initiatives.
A critical review of the nursing shortage in Malaysia
Authors: Barnett T. , Namasivayam P. , Narudin D.A.A. 
Published: February 2010

BARNETT T., NAMASIVAYAM P. & NARUDIN D.A.A. (2010) A critical review of the nursing shortage in Malaysia. International Nursing Review57, 32–39Objective:  This paper describes and critically reviews steps taken to address the nursing workforce shortage in Malaysia.Background:  To address the shortage and to build health care capacity, Malaysia has more than doubled its nursing workforce over the past decade, primarily through an increase in the domestic supply of new graduates.Methods:  Government reports, policy documents and ministerial statements were sourced from the Ministry of Health Malaysia website and reviewed and analysed in the context of the scholarly literature published about the health care workforce in Malaysia and more generally about the global nursing shortage.Results:  An escalation in student numbers and the unprecedented number of new graduates entering the workforce has been associated with other impacts that have been responded to symptomatically rather than through workplace reform. Whilst growing the domestic supply of nurses is a critical key strategy to address workforce shortages, steps should also be taken to address structural and other problems of the workplace to support both new graduates and the retention of more experienced staff.Conclusion:  Nursing shortages should not be tackled by increasing the supply of new graduates alone. The creation of a safe and supportive work environment is important to the long‐term success of current measures taken to grow the workforce and retain nurses within the Malaysian health care system.
Italian–Moldovan international nurse migration: rendering visible the loss of human capital
Authors: Palese A. , Cristea E. , Mesaglio M. , Stempovscaia E. 
Published: February 2010

PALESE A., CRISTEA E., MESAGLIO M. & STEMPOVSCAIA E. (2010) Italian–Moldovan international nurse migration: rendering visible the loss of human capital. International Nursing Review57, 64–69Aim:  To describe the process of the migration of Moldovan nurses to Italy.Background:  Formerly a part of the Soviet Union, the Republic of Moldova gained independence in 1991. Currently, there are 25 848 nurses (60.6 per 10 000 inhabitants) working mainly in the public health system. Each year, around 2000 nurses leave the country in search of better working conditions and a better quality of life.Methods:  A longitudinal study design was adopted (2006–2007). In the first phase, we contacted all known nurses living in Moldova and their available colleagues following a snowball sampling strategy. Inclusion criteria were nurses who had decided to migrate to Italy and had already prepared the migration documents and/or were awaiting their departure. In the second phase, we interviewed the same sample of nurses on arrival in Italy.Findings:  After one year, only 25 nurses out of the 110 initially interviewed (22.7%) had arrived in Italy; none were working as nurses. The cost of the migration process incurred by each nurse was around 3278 euros, and the waiting time from the decision to leave until arrival was around 24 months.Conclusions:  All Moldovan nurses involved in this study, once they arrived in Italy, ceased to exist from an official perspective. Policy and recommendations need to be developed to ensure the integration of Moldovan‐educated nurses into the health‐care system and to monitor the amount of human capital (in terms of care drain, brain drain and youth drain) that this process risks wasting.
A biogeographic model of fire regimes in Australia: current and future implications
Authors: Bradstock R. A. 
Published: February 2010

ABSTRACTAim  Patterns of fire regimes across Australia exhibit biogeographic variation in response to four processes. Variations in area burned and fire frequency result from differences in the rates of ‘switching’ of biomass growth, availability to burn, fire weather and ignition. Therefore differing processes limit fire (i.e. the lowest rate of switching) in differing ecosystems. Current and future trends in fire frequency were explored on this basis.Location  Case studies of forests (cool temperate to tropical) and woodlands (temperate to arid) were examined. These represent a broad range of Australian biomes and current fire regimes.Methods  Information on the four processes was applied to each case study and the potential minimum length of interfire interval was predicted and compared to current trends. The potential effects of global change on the processes were then assessed and future trends in fire regimes were predicted.Results  Variations in fire regimes are primarily related to fluctuations in available moisture and dominance by either woody or herbaceous plant cover. Fire in woodland communities (dry climates) is limited by growth of herbaceous fuels (biomass), whereas in forests (wet climates) limitation is by fuel moisture (availability to burn) and fire weather. Increasing dryness in woodland communities will decrease potential fire frequency, while the opposite applies in forests. In the tropics, both forms of limitation are weak due to the annual wet/dry climate. Future change may therefore be constrained.Main conclusions  Increasing dryness may diminish fire activity over much of Australia (dominance of dry woodlands), though increases may occur in temperate forests. Elevated CO2 effects may confound or reinforce these trends. The prognosis for the future fire regime in Australia is therefore uncertain.
Functional and physical interactions between formyl‐peptide‐receptors and scavenger receptor MARCO and their involvement in amyloid beta 1–42‐induced signal transduction in glial cells
Authors: Brandenburg Lars‐Ove , Konrad Maximilian , Wruck Christoph J. , Koch Thomas , Lucius Ralph , Pufe Thomas 
Published: February 2010

J. Neurochem. (2010) 113, 749–760.AbstractRecent studies suggest that the chemotactic G protein‐coupled receptor formyl‐peptide‐receptor‐like‐1 (FPRL1) or the scavenger receptor MARCO (macrophage receptor with collagenous structure) plays an essential role in the inflammatory response of host defense mechanisms and neurodegenerative disorders such as Alzheimer’s disease. We therefore analyzed the involvement of FPRL1 and MARCO in amyloid β1–42 (Aβ1–42)‐induced signalling by extracellular‐signal regulated kinases 1/2 (ERK1/2) phosphorylation and cAMP level measurement in glial cells (astrocytes and microglia) and in transfected HEK293 cells. Receptors were inhibited by small interference RNA and the consequences in Aβ1–42‐ and MARCO agonist fucoidan‐induced signal transduction were determined. Receptor deactivation by antagonists or small interference RNA verified the importance of FPRL1 for Aβ1–42‐mediated signal transduction by ERK1/2 phosphorylation and cAMP level measurement in glial cells. Furthermore, for the first time, we have demonstrated a functional interaction between FPRL1 and scavenger receptors in fucoidan‐mediated signalling by ERK1/2 phosphorylation and cAMP level measurement. In addition, co‐immunoprecipitation data and fluorescence microscopy measurements revealed a physical interaction between FPR, FPRL1 and MARCO. These results suggest that FPRL1 plays a pivotal role for Aβ1–42‐induced signal transduction in glial cells and the interaction with MARCO could explain the broad ligand spectrum of formyl peptide receptors.
Dynamic monitoring of NET activity in mature murine sympathetic terminals using a fluorescent substrate
Authors: Parker Lauren K , Shanks Julia A , Kennard James AG , Brain Keith L 
Published: February 2010

Background and purpose: To validate a fluorescence approach for monitoring norepinephrine transporter (NET) transport rate in mature sympathetic terminals, and to determine how prejunctional muscarinic receptors affect NET rate.Experimental approach: Confocal imaging of a fluorescent NET substrate [neurotransmitter transporter uptake assay (NTUA)] as it accumulates in the mature sympathetic nerve terminals of the mouse isolated vas deferens. Fluorescence recovery after photobleaching (FRAP), enhanced green fluorescence protein (EGFP)‐transgenic mice and contraction studies were also used.Key results: NTUA fluorescence accumulated linearly in nerve terminals, an effect that was prevented with NET inhibition with desipramine (1 µM). Such accumulation was reversed by amphetamine (10 µM), which is known to reverse the direction of transport of NET substrates. NTUA labelling was not present in cholinergic terminals (identified using EGFP fluorescence expressed in transgenic mice under a choline acetyltransferase promoter). FRAP experiments, altered nerve terminal distribution with reserpine pretreatment and co‐imaging in terminals filled with a cytoplasmic marker (Alexa 594 dextran) indicated that the NTUA labelling was largely confined to vesicles within varicosities; vesicular exchange between varicosities was rare. The rate of NTUA accumulation was slower in the presence of the muscarinic agonist carbachol (10 µM) demonstrating muscarinic inhibition of NET rate.Conclusions and implications: A straightforward protocol now exists to monitor NET transport rate at the level of the single nerve terminal varicosity, providing a useful tool to understand the physiology of NET regulation, the action of NET inhibitors on mature sympathetic terminals, dynamic vesicular tracking and to identify sympathetic terminals from mixed terminal populations in living organs.This article is part of a themed section on Imaging in Pharmacology. To view the editorial for this themed section visithttp://dx.doi.org/10.1111/j.1476‐5381.2010.00685.x
A role for transient receptor potential vanilloid 4 in tonicity‐induced neurogenic inflammation
Authors: Vergnolle N , Cenac N , Altier C , Cellars L , Chapman K , Zamponi GW , Materazzi S , Nassini R , Liedtke W , Cattaruzza F , Grady EF , Geppetti P , Bunnett NW 
Published: February 2010

Background and purpose:  Changes in extracellular fluid osmolarity, which occur after tissue damage and disease, cause inflammation and maintain chronic inflammatory states by unknown mechanisms. Here, we investigated whether the osmosensitive channel, transient receptor potential vanilloid 4 (TRPV4), mediates inflammation to hypotonic stimuli by a neurogenic mechanism.Experimental approach:  TRPV4 was localized in dorsal root ganglia (DRG) by immunofluorescence. The effects of TRPV4 agonists on release of pro‐inflammatory neuropeptides from peripheral tissues and on inflammation were examined.Key results:  Immunoreactive TRPV4 was detected in DRG neurones innervating the mouse hindpaw, where it was co‐expressed in some neurones with CGRP and substance P, mediators of neurogenic inflammation. Hypotonic solutions and 4α‐phorbol 12,13‐didecanoate, which activate TRPV4, stimulated neuropeptide release in urinary bladder and airways, sites of neurogenic inflammation. Intraplantar injection of hypotonic solutions and 4α‐phorbol 12,13‐didecanoate caused oedema and granulocyte recruitment. These effects were inhibited by a desensitizing dose of the neurotoxin capsaicin, antagonists of CGRP and substance P receptors, and TRPV4 gene knockdown or deletion. In contrast, antagonism of neuropeptide receptors and disruption of TRPV4 did not prevent this oedema. TRPV4 gene knockdown or deletion also markedly reduced oedema and granulocyte infiltration induced by intraplantar injection of formalin.Conclusions and implications:  Activation of TRPV4 stimulates neuropeptide release from afferent nerves and induces neurogenic inflammation. This mechanism may mediate the generation and maintenance of inflammation after injury and during diseases, in which there are changes in extracellular osmolarity. Antagonism of TRPV4 may offer a therapeutic approach for inflammatory hyperalgesia and chronic inflammation.
A comparative analysis of the activity of ligands acting at P2X and P2Y receptor subtypes in models of neuropathic, acute and inflammatory pain
Authors: Andó RD , Méhész B , Gyires K , Illes P , Sperlágh B 
Published: February 2010

Background and purpose: This study was undertaken to compare the analgesic activity of antagonists acting at P2X1, P2X7, and P2Y12 receptors and agonists acting at P2Y1, P2Y2, P2Y4, and P2Y6 receptors in neuropathic, acute, and inflammatory pain.Experimental approach: The effect of the wide spectrum P2 receptor antagonist PPADS, the selective P2X7 receptor antagonist Brilliant Blue G (BBG), the P2X1 receptor antagonist (4,4′,4″,4‐[carbonylbis(imino‐5,1,3‐benzenetriyl‐bis(carbonylimino))]tetrakis‐1,3‐benzenedisulfonic acid, octasodium salt (NF449) and (8,8′‐[carbonylbis(imino‐3,1‐phenylenecarbonylimino)]bis‐1,3,5‐naphthalene‐trisulphonic acid, hexasodium salt (NF023), the P2Y12 receptor antagonist (2,2‐dimethyl‐propionic acid 3‐(2‐chloro‐6‐methylaminopurin‐9‐yl)‐2‐(2,2‐dimethyl‐propionyloxymethyl)‐propylester (MRS2395), the selective P2Y1 receptor agonist ([[(1R,2R,3S,4R,5S)‐4‐[6‐amino‐2‐(methylthio)‐9H‐purin‐9‐yl]‐2,3‐dihydroxybicyclo[3.1.0]hex‐1‐yl]methyl] diphosphoric acid mono ester trisodium salt (MRS2365), the P2Y2/P2Y4 agonist uridine‐5′‐triphosphate (UTP), and the P2Y4/P2Y6 agonist uridine‐5′‐diphosphate (UDP) were examined on mechanical allodynia in the Seltzer model of neuropathic pain, on acute thermal nociception, and on the inflammatory pain and oedema induced by complete Freund's adjuvant (CFA).Key results: MRS2365, MRS2395 and UTP, but not the other compounds, significantly alleviated mechanical allodynia in the neuropathic pain model, with the following rank order of minimal effective dose (mED) values: MRS2365 > MRS2395 > UTP. All compounds had a dose‐dependent analgesic action in acute pain except BBG, which elicited hyperalgesia at a single dose. The rank order of mED values in acute pain was the following: MRS2365 > MRS2395 > NF449 > NF023 > UDP = UTP > PPADS. MRS2365 and MRS2395 had a profound, while BBG had a mild effect on inflammatory pain, with a following rank order of mED values: MRS2395 > MRS2365 > BBG. None of the tested compounds had significant action on oedema evoked by intraplantar injection of CFA.Conclusions and implications: Our results show that antagonism at P2X1, P2Y12, and P2X7 receptors and agonism at P2Y1 receptors define promising therapeutic strategies in acute, neuropathic, and inflammatory pain respectively.
Fluorescent ligand binding reveals heterogeneous distribution of adrenoceptors and ‘cannabinoid‐like’ receptors in small arteries
Authors: Daly CJ , Ross RA , Whyte J , Henstridge CM , Irving AJ , McGrath JC 
Published: February 2010

Background and purpose: Pharmacological analysis of synergism or functional antagonism between different receptors commonly assumes that interacting receptors are located in the same cells. We have now investigated the distribution of α‐adrenoceptors, β‐adrenoceptors and cannabinoid‐like (GPR55) receptors in the mouse arteries.Experimental approach: Fluorescence intensity from vascular tissue incubated with fluorescent ligands (α1‐adrenoceptor ligand, BODIPY‐FL‐prazosin, QAPB; β‐adrenoceptor ligand, TMR‐CGP12177; fluorescent angiotensin II; a novel diarylpyrazole cannabinoid ligand (Tocrifluor 1117, T1117) was measured with confocal microscopy. Small mesenteric and tail arteries of wild‐type and α1B/D‐adrenoceptor‐KO mice were used.Key results: T1117, a fluorescent form of the cannabinoid CB1receptor antagonist AM251, was a ligand for GPR55, with low affinity for CB1receptors. In mesenteric arterial smooth muscle cells, α1A‐adrenoceptors were predominantly located in different cells from those with β‐adrenoceptors, angiotensin receptors or cannabinoid‐like (GPR55) receptors. Cells with β‐adrenoceptors predominated at arterial branches. Endothelial cells expressed β‐adrenoceptors, α‐adrenoceptors and cannabinoid‐like receptors. Only endothelial α‐adrenoceptors appeared in clusters. Adventitia was a rich source of G protein‐coupled receptors (GPCRs), particularly fibroblasts and nerve tracts, where Schwann cells bound α‐adrenoceptor, β‐adrenoceptor and CB‐receptor ligands, with a mix of separate receptor locations and co‐localization.Conclusions and implications: Within each cell type, each GPCR had a distinctive heterogeneous distribution with limited co‐localization, providing a guide to the possibilities for functional synergism, and suggesting a new paradigm for synergism in which interactions may be either between cells or involve converging intracellular signalling processes.This article is part of a themed section on Imaging in Pharmacology. To view the editorial for this themed section visithttp://dx.doi.org/10.1111/j.1476‐5381.2010.00685.x