bluuebunny/crossref_metadata_2025_split huggingface dataset:
Programa lúdico-pedagógico para o controle do biofilme dental em indivíduos com deficiência visual
Authors: Haddad Denise Sabbagh- , Haddad Denise Sabbagh- , Haddad Aida Sabbagh- , Guaré Renata de Oliveira 
Published: March 2012

Objetivo: Desenvolver um programa de prevenção e motivação odontológica para deficientes visuais, utilizando materiais lúdico-pedagógicos. Além disso, buscou comparar a eficácia do mesmo através do índice de higiene oral simplificado (IHOS) e do índice gengival (IG), em um grupo de cegos (grupoexperimental) e portadores de visão subnormal (grupo controle). Matérias e Métodos: Foram avaliados 15 indivíduos com deficiência visual da Associação de Pais e Amigos dos Deficientes Visuais (APADEV), de Caxias do Sul/RS, de ambos os sexos e idades entre 13 e 49 anos. Foram divididos em dois grupos: cegos (grupo experimental) e portadores de visão subnormal (grupo controle). Durante seis encontros (inicial, 15, 45, 75, 105 e 120 dias), todos os participantes receberam as mesmas informações e participaram dasmesmas atividades conduzidas pelo mesmo examinador (kappa=0,86). Após cada atividade realizava-se o IG e IHOS. Os dados foram avaliados considerando-se o nível de significância de 5% e utilizando-se os testesde Friedman e Mann-Whitney. Resultados: Em relação ao IHOS, houve diminuição do índice com diferença significativa para o grupo controle durante os momentos de 15 a 105 dias (p<0,01), o que não ocorreu como grupo experimental (p=0,77). Na avaliação do IG, observou-se diminuição do índice ao longo de todo o período no grupo controle (p<0,01). No grupo com deficiência visual o IG diminuiu entre 75 e 105 dias. Parao IHOS não houve diferenças estatisticamente significantes. Conclusão: Os indivíduos com visão subnormal apresentaram um efeito melhor (IG e IHOS) após o programa quando comparados com os indivíduos cegos.Descritores: Portadores de deficiências visuais. Motivação. Placa dentária. Higiene bucal.
Honorários praticados por operadoras de planos odontológicos e pelo SUS em relação aos definidos pelo Conselho Federal de Odontologia
Authors: Saliba Orlando , Góes Bruno Cabus , Garbin Cléa Adas Saliba , Santos Renata Reis dos , Garbin Artênio José Isper 
Published: March 2012

Objetivo: Investigou-se o repasse de honorário ao cirurgião-dentista ofertado pelas empresas operadoras de planos odontológicos por grupos de procedimentos odontológicos. Materiais e Métodos: Os valores praticados por operadoras de planos foram definidos a partir da média obtida entre valoresdas tabelas de cinco planos com abrangência nacional. Esses valores médios e os valores pagos pelo SUS foram comparados com os estabelecidos na tabela VRCC – CFO. Para a comparação, foram obtidos valores médios para os seguintes grupos de procedimentos: preventivos, de dentística, de endodontia e de cirurgia. Os valores dos procedimentos preventivos foram comparados com os demais grupos de procedimentos. Resultados: Os planos aplicaram um desconto médio de 54,51% sobre os preços sugeridos pelo CFO. O maior desconto foi observado no grupo de procedimentos preventivos (57,09%, em média). Conclusão: As empresas operadoras de planos e convênios investigadas estão aplicando um desconto abusivo sob os preçossugeridos pelo CFO. É necessário identificar alternativas para que se possam reverter o quadro identificado por esse estudo.Descritores: Honorários odontológicos. Seguro odontológico. Planos de sistemas de saúde.
Avaliação do conhecimento e práticas dos pais quanto a saúde bucal dos filhos de 3 a 9 anos de idade
Authors: Santos Yara Mendes dos , Jorge Maria Letícia Ramos- , Paiva Saul Martins , Ferreira Meire Coelho 
Published: March 2012

Objetivo: Avaliar o conhecimento e práticas de pais quanto a saúde bucal dos filhos entre 3 e 9 anos de idade, atendidos em um consultório particular. Materiais e Métodos: A amostra foi composta de 21 crianças/pais. A coleta de dados foi realizada através de exame clínico das crianças e de questionárioauto-aplicado aos pais durante as consultas odontológicas. Os dados foram submetidos à análise descritiva e aos testes Qui-quadrado (χ2) e Exato de Fisher (a < 0,05). Resultados: Para 85,7% dos responsáveis, o fator causal para cárie dentária foi “não escovar os dentes”, assim como para a amostra total quanto à doença periodontal. Somente 14,3% dos responsáveis considerou que a alimentação influencia na saúde dental, 57% não souberam dizer qual a função do flúor e 52,4% não souberam dizer quais produtos contém flúor. Em 57% das crianças, a higiene bucal era executada pelo responsável, no entanto, somente 38% desses dispensava o creme dental na escova. Noventa por cento das crianças consumiam açúcar mais de 3X/semana, sendo que 47,6% do consumo ocorria durante as refeições principais. Associação significativa foi observada entre “responsável assalariado ou não” e “frequência de higiene bucal da criança”, entre “renda familiar mensal” e “frequência de higiene bucal da criança” (p = 0,030; 0,032, respectivamente). Conclusão: Apesar dos responsáveis já terem tido contato com o cirurgião dentista e seus filhos estarem em tratamento odontológico, os conhecimentos que detém sobre saúde bucal são superficiais, tanto quanto aos fatores causais das doençasbucais mais prevalentes, como em relação a produtos de higiene. Desta forma, é preciso que ações educativopreventivas sejam construídas em bases sólidas a fim de que o conhecimento repassado aos responsáveis/filhos possibilite o estabelecimento de práticas de forma constante e segura para a manutenção e/ou aquisição de saúde bucal.Descritores: Prática privada. Saúde bucal. Pais. Criança.
Locally inertial reference frames in Lorentzian and Riemann‐Cartan spacetimes
Authors: Giglio J.F.T. , Rodrigues W.A. 
Published: March 2012

AbstractIn this paper the concept of locally inertial reference frames (LIRFs) in Lorentzian and Riemann‐Cartan spacetime structures is scrutinized. A rigorous mathematical definition of a LIRF in both structures is given, something that needs preliminary a clear mathematical distinction between the concepts of observers, reference frames, naturally adapted coordinate functions to a given reference frame and which properties may characterize an inertial reference frame (if any) in the Lorentzian and Riemann‐Cartan structures. Hopefully, the paper clarifies some obscure issues associated to the concept of a LIRF appearing in the literature, in particular the relationship between LIRFs in Lorentzian and Riemann‐Cartan spacetimes and Einstein's most happy thought, i.e., the equivalence principle.
Cytoarchitecture of the Spinal Cord of the Postnatal (P4) Mouse
Authors: Sengul Gulgun , Puchalski Ralph B. , Watson Charles 
Published: March 2012

AbstractInterpretation of the new wealth of gene expression and molecular mechanisms in the developing mouse spinal cord requires an accurate anatomical base on which data can be mapped. Therefore, we have assembled a spinal cord atlas of the P4 mouse to facilitate direct comparison with the adult specimens and to contribute to studies of the development of the mouse spinal cord. This study presents the anatomy of the spinal cord of the P4 C57Bl/6J mouse using Nissl and acetyl cholinesterase‐stained sections. It includes a detailed map of the laminar organization of selected spinal cord segments and a description of named cell groups of the spinal cord such as the central cervical (CeCv), lateral spinal nucleus, lateral cervical, and dorsal nuclei. The motor neuron groups have also been identified according to the muscle groups they are likely to supply. General features of Rexed's laminae of the P4 spinal cord showed similarities to that of the adult (P56). However, certain differences were observed with regard to the extent of laminae and location of certain cell groups, such as the dorsal nucleus having a more dispersed structure and a more ventral and medial position or the CeCv being located in the medial part of lamina 5 in contrast to the adult where it is located in lamina 7. Motor neuron pools appeared to be more tightly packed in the P4 spinal cord. The dorsal horn was relatively larger and there was more white matter in the P56 spinal cord. Anat Rec, 2012. © 2012 Wiley Periodicals, Inc.
LC‐MS/MS method for simultaneous analysis of uracil, 5,6‐dihydrouracil, 5‐fluorouracil and 5‐fluoro‐5,6‐dihydrouracil in human plasma for therapeutic drug monitoring and toxicity prediction in cancer patients
Authors: Büchel Barbara , Rhyn Peter , Schürch Stefan , Bühr Claudia , Amstutz Ursula , R. Largiadèr Carlo 
Published: March 2012

ABSTRACTThe chemotherapeutic drug 5‐fluorouracil (5‐FU) is widely used for treating solid tumors. Response to 5‐FU treatment is variable with 10–30% of patients experiencing serious toxicity partly explained by reduced activity of dihydropyrimidine dehydrogenase (DPD). DPD converts endogenous uracil (U) into 5,6‐dihydrouracil (UH2), and analogously, 5‐FU into 5‐fluoro‐5,6‐dihydrouracil (5‐FUH2). Combined quantification of U and UH2 with 5‐FU and 5‐FUH2 may provide a pre‐therapeutic assessment of DPD activity and further guide drug dosing during therapy. Here, we report the development of a liquid chromatography–tandem mass spectrometry assay for simultaneous quantification of U, UH2, 5‐FU and 5‐FUH2 in human plasma. Samples were prepared by liquid–liquid extraction with 10:1 ethyl acetate‐2‐propanol (v/v). The evaporated samples were reconstituted in 0.1% formic acid and 10 μL aliquots were injected into the HPLC system. Analyte separation was achieved on an Atlantis dC18 column with a mobile phase consisting of 1.0 mm ammonium acetate, 0.5 mm formic acid and 3.3% methanol. Positively ionized analytes were detected by multiple reaction monitoring. The analytical response was linear in the range 0.01–10 μm for U, 0.1–10 μm for UH2, 0.1–75 μm for 5‐FU and 0.75–75 μm for 5‐FUH2, covering the expected concentration ranges in plasma. The method was validated following the FDA guidelines and applied to clinical samples obtained from ten 5‐FU‐treated colorectal cancer patients. The present method merges the analysis of 5‐FU pharmacokinetics and DPD activity into a single assay representing a valuable tool to improve the efficacy and safety of 5‐FU‐based chemotherapy. Copyright © 2012 John Wiley & Sons, Ltd.
Photomagnetism of a sym‐cis‐Dithiocyanato Iron(II) Complex with a Tetradentate N,N′‐Bis(2‐pyridylmethyl)1,2‐ethanediamine Ligand
Authors: Létard Jean‐François , Asthana Saket , Shepherd Helena J. , Guionneau Philippe , Goeta André E. , Suemura Naohiko , Ishikawa Ryuta , Kaizaki Sumio 
Published: March 2012

AbstractA comprehensive study of the magnetic and photomagnetic behaviors of cis‐[Fe(picen)(NCS)2] (picen=N,N′‐bis(2‐pyridylmethyl)1,2‐ethanediamine) was carried out. The spin‐equilibration was extremely slow in the vicinity of the thermal spin‐transition. When the cooling speed was slower than 0.1 K min−1, this complex was characterized by an abrupt thermal spin‐transition at about 70 K. Measurement of the kinetics in the range 60–70 K was performed to approach the quasi‐static hysteresis loop. At low temperatures, the metastable HS state was quenched by a rapid freezing process and the critical T(TIESST) temperature, which was associated with the thermally induced excited spin‐state‐trapping (TIESST) effect, was measured. At 10 K, this complex also exhibited the well‐known light‐induced excited spin‐state‐trapping (LIESST) effect and the T(LIESST) temperature was determined. The kinetics of the metastable HS states, which were generated from the freezing effect and from the light‐induced excitation, was studied. Single‐crystal X‐ray diffraction as a function of speed‐cooling and light conditions at 30 K revealed the mechanism of the spin‐crossover in this complex as well as some direct relationships between its structural properties and its spin state. This spin‐crossover (SCO) material represents a fascinating example in which the metastability of the HS state is in close vicinity to the thermal spin‐transition region. Moreover, it is a beautiful example of a complex in which the metastable HS states can be generated, and then compared, either by the freezing effect or by the LIESST effect.
Giant cell tumor of tendon sheath: Cytomorphologic and radiologic findings in 41 patients
Authors: Ho Cheng‐Ying , Maleki Zahra 
Published: March 2012

AbstractGiant cell tumor of tendon sheath (GCTTS) is a common soft tissue lesion and presents as a firm, slow‐growing, non‐tender mass adjacent to the tendon sheath. It can be further classified into diffuse or localized types based on its growth pattern. Using cytomorphologic analysis, we assessed the feasibility of fine‐needle aspiration (FNA) as an initial diagnostic modality for GCTTS. Forty‐one cases of image‐guided FNA of GCTTS were retrospectively retrieved from the archives of The Johns Hopkins Hospital. Clinical information, imaging studies, histopathology, and other ancillary studies were also reviewed. The majority of the cytology specimens demonstrated hypercellularity. A uniform population of spindled to polygonal stromal cells constituted more than half of the cellularity. Other cell types frequently present included multinucleated giant cells, hemosiderin‐laden macrophages, and foamy histiocytes. Nuclear grooves or intranuclear pseudo‐inclusions present in stromal cells were also distinctive cytomorphologic features, but only present in less than a quarter of the cases. Our study has shown the usefulness and accuracy of imaging‐guided FNA as a diagnostic tool for GCTTS. Diagnostic accuracy can be optimized with a thorough review of clinical history, careful physical examination, and radiologic correlation. Diagn. Cytopathol. 2012; © 2012 Wiley Periodicals, Inc.
Green‐Ampt Curve‐Number mixed procedure as an empirical tool for rainfall–runoff modelling in small and ungauged basins
Authors: Grimaldi S. , Petroselli A. , Romano N. 
Published: March 2012

AbstractThe Soil Conservation Service Curve Number (SCS‐CN) method is a popular rainfall–runoff model that is widely used to estimate direct runoff from small and ungauged basins. The SCS‐CN is a simple and valuable approach to quantify the total streamflow volume generated by storm rainfall, but its use is not appropriate for estimating the sub‐daily incremental rainfall excess. To overcome this drawback, we propose to include the Green‐Ampt (GA) infiltration model into a mixed procedure, which is referred to as Curve Number for Green‐Ampt (CN4GA), aiming to distribute in time the information provided by the SCS‐CN method. For a given storm, the computed SCS‐CN total net rainfall amount is employed to calibrate the soil hydraulic conductivity parameter of the GA model. The proposed procedure is evaluated by analysing 100 rainfall–runoff events that were observed in four small catchments of varying size. CN4GA appears to provide encouraging results for predicting the net rainfall peak and duration values and has shown, at least for the test cases considered in this study, better agreement with the observed hydrographs than the classic SCS‐CN method. Copyright © 2012 John Wiley & Sons, Ltd.
Molecular and cellular mechanisms involved in the Trypanosoma cruzi/host cell interplay
Authors: Romano Patricia Silvia , Cueto Juan Agustín , Casassa Ana Florencia , Vanrell María Cristina , Gottlieb Roberta A. , Colombo María Isabel 
Published: March 2012

AbstractThe protozoan parasite Trypanosoma cruzi has a complex biological cycle that involves vertebrate and invertebrate hosts. In mammals, the infective trypomastigote form of this parasite can invade several cell types by exploiting phagocytic‐like or nonphagocytic mechanisms depending on the class of cell involved. Morphological studies showed that when trypomastigotes contact macrophages, they induce the formation of plasma membrane protrusions that differ from the canonical phagocytosis that occurs in the case of noninfective epimastigotes. In contrast, when trypomastigotes infect epithelial or muscle cells, the cell surface is minimally modified, suggesting the induction of a different class of process. Lysosomal‐dependent or ‐independent T. cruzi invasion of host cells are two different models that describe the molecular and cellular events activated during parasite entry into nonphagocytic cells. In this context, we have previously shown that induction of autophagy in host cells before infection favors T. cruzi invasion. Furthermore, we demonstrate that autophagosomes and the autophagosomal protein LC3 are recruited to the T. cruzi entry sites and that the newly formed T. cruzi parasitophorous vacuole has characteristics of an autophagolysosome. This review summarizes the current knowledge of the molecular and cellular mechanisms of T. cruzi invasion in nonphagocytic cells. Based on our findings, we propose a new model in which T. cruzi takes advantage of the upregulation of autophagy during starvation to increase its successful colonization of host cells. 2012 IUBMB IUBMB Life, 2012
Osteogenic differentiation of osteoblasts induced by calcium silicate and calcium silicate/β‐tricalcium phosphate composite bioceramics
Authors: Fei Lisha , Wang Chen , Xue Yang , Lin Kaili , Chang Jiang , Sun Jiao 
Published: March 2012

AbstractIn this study, calcium silicate (CS) and CS/β‐tricalcium phosphate (CS/β‐TCP) composites were investigated on their mechanism of osteogenic proliferation and differentiation through regulating osteogenic‐related gene and proteins. Osteoblast‐like cells were cultured in the extracts of these CS‐based bioceramics and pure β‐TCP, respectively. The main ionic content in extracts was analyzed by inductively coupled plasma‐atomic emission spectroscopy. The cell viability, mineralization, and differentiation were evaluated by MTT assay, Alizarin Red‐S staining and alkaline phosphatase (ALP) activity assay. The expressions of BMP‐2, transforming growth factor‐β (TGF‐β), Runx2, ALP, and osteocalcin (OCN) at both gene and protein level were detected by real‐time polymerase chain reaction analysis and Western blot. The result showed that the extracts of CS‐based bioceramics promoted cells proliferation, differentiation, and mineralization when compared with pure β‐TCP. Accordingly, pure CS and CS/β‐TCP composites stimulated osteoblast‐like cells to express BMP‐2/TGF‐β gene and proteins, and further regulate the expression of Runx2 gene and protein, and ultimately affect the ALP activity and OCN deposition. This study suggested that the CS‐based bioceramics could not only promote the expression of osteogenic‐related genes but also enhance the genes to encode the corresponding proteins, which could finally control osteoblast‐like cells proliferation and differentiation. © 2012 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2012.
Large neighborhood search for the pickup and delivery traveling salesman problem with multiple stacks
Authors: Côté Jean‐François , Gendreau Michel , Potvin Jean‐Yves 
Published: March 2012

AbstractThis article studies a single vehicle pickup and delivery problem with loading constraints. In this problem, the vehicle contains a number of (horizontal) stacks of finite capacity for loading items from the rear of the vehicle. Each stack must satisfy a last‐in‐first‐out constraint where any new item must be loaded on top of a stack and any unloaded item must be on top of its stack. A large neighborhood search is proposed for solving this problem. Computational results are reported on different types of randomly generated instances. Results are also reported on benchmark instances for two special cases of our problem and a comparison is provided with state‐of‐the‐art methods. © 2012 Wiley Periodicals, Inc. NETWORKS, 2012
A new process for dissolution of cellulose in ionic liquids
Authors: Cai Tao , Yang Gesheng , Zhang Huihui , Shao Huili , Hu Xuechao 
Published: March 2012

AbstractA new dissolving process (two‐step dissolving process), that is, cellulose was first swelled to the maximum in aqueous 1‐butyl‐3‐methylimidazolium chloride ([BMIM]Cl) solution, and then dissolved by stirring under vacuum to remove excessive water, was developed to prepare the cellulose/[BMIM]Cl spinning dope with high quality. The results showed that the initial water contents in [BMIM]Cl have great influence on the swelling and dissolution of cellulose, and the suitable swelling range of aqueous [BMIM]Cl solution, in which cellulose can be swollen but not dissolved, was 2–5% water content. In this range, the higher water content in aqueous [BMIM]Cl solution, the more swelling time would be taken for cellulose to reach the maximal swelling ratio. Based on these results, cellulose/[BMIM]Cl spinning dopes were prepared by using two‐step dissolving process. In the range of our experiments, cellulose spinning dopes prepared by the two‐step dissolving process had better properties, such as fewer particles, lower apparent viscosity, and higher uniformity, compared with the direct dissolving process. By using this new dissolving process, the spinning performance of cellulose/[BMIM]Cl dopes was improved, and the mechanical properties of regenerated cellulose fibers were better than those prepared by the direct dissolving process. Therefore, it is a good way to prepare cellulose/[BMIM]Cl spinning dopes by using the new dissolving process. POLYM. ENG. SCI., 2012. © 2012 Society of Plastics Engineers
Sensitivity of state‐of‐the‐art and high efficiency crystalline silicon solar cells to metal impurities
Authors: Coletti Gianluca 
Published: March 2012

ABSTRACTFor the first time, the sensitivity to impurities of the solar cell conversion efficiency is reported for a state‐of‐the‐art (i.e., 18%) and advanced device architecture (i.e., 23%). The data are based on the experimental results obtained in the CrystalClear project for the state‐of‐the‐art cell process and extrapolated to a device with excellent front and rear surface passivation. Both device structures are not assumed to work in low injection level as several studies assumed before, but real operating conditions are considered. This is a fundamental difference with the past and required for modeling future high efficiency devices. The impurity with highest impact is Ti, followed by Cu, Cr, Ni and Fe, which form together a group two order of magnitude less sensitive than the former. In high efficiency devices, a large reduction of the impurity impact is visible for impurities with large capture cross‐section ratio like Fe, which reduces its relative difference in comparison with, for example, Cr, which has a small capture cross‐section ratio. In general, advanced devices will be more sensitive to the impurity content than the state‐of‐the‐art cell design. This effect is partly compensated by a reduction of the substrate thickness. The impurity sensitivity as function of the substrate thickness is reported. Copyright © 2012 John Wiley & Sons, Ltd.