bluuebunny/crossref_metadata_2025_split huggingface dataset:
Complement C3a, CpG Oligos, and DNA/C3a Complex Stimulate IFN-α Production in a Receptor for Advanced Glycation End Product-Dependent Manner
Authors: Ruan Benfang Helen , Li Xin , Winkler Aaron R. , Cunningham Kristina M. , Kuai Jun , Greco Rita M. , Nocka Karl H. , Fitz Lori J. , Wright Jill F. , Pittman Debra D. , Tan Xiang-Yang , Paulsen Janet E. , Lin Lih Ling , Winkler David G. 
Published: September 2010

Abstract
The receptor for advanced glycation end products (RAGE) is a multiligand transmembrane receptor implicated in a number of diseases including autoimmune diseases. To further understand the pathogenic mechanism of RAGE in these diseases, we searched for additional ligands. We discovered that C3a bound to RAGE with an EC50 of 1.9 nM in an ELISA, and the binding was increased both in magnitude (by &gt;2-fold) and in affinity (EC50 70 pM) in the presence of human stimulatory unmethylated cytosine-guanine-rich DNA A (hCpGAs). Surface plasmon resonance and fluorescence anisotropy analyses demonstrated that hCpGAs could bind directly to RAGE and C3a and form a ternary complex. In human PBMCs, C3a increased IFN-α production in response to low levels of hCpGAs, and this synergy was blocked by soluble RAGE or by an Ab directed against RAGE. IFN-α production was reduced in response to mouse CpGAs and C3a in RAGE−/− mouse bone marrow cells compared wild-type mice. Taken together, these data demonstrate that RAGE is a receptor for C3a and CpGA. Through direct interaction, C3a and CpGA synergize to increase IFN-α production in a RAGE-dependent manner and stimulate an innate immune response. These findings indicate a potential role of RAGE in autoimmune diseases that show accumulation of immunostimulatory DNA and C3a.
IL-27/IFN-γ Induce MyD88-Dependent Steroid-Resistant Airway Hyperresponsiveness by Inhibiting Glucocorticoid Signaling in Macrophages
Authors: Li Jing Jing , Wang Wan , Baines Katherine J. , Bowden Nikola A. , Hansbro Philip M. , Gibson Peter G. , Kumar Rakesh K. , Foster Paul S. , Yang Ming 
Published: September 2010

Abstract
Inflammation and airway hyperresponsiveness (AHR) are hallmark features of asthma and often correlate with the severity of clinical disease. Although these features of asthma can be effectively managed with glucocorticoid therapy, a subgroup of patients, typically with severe asthma, remains refractory to therapy. The mechanisms leading to steroid resistance in severe asthmatics are poorly understood but may be related to the activation of innate host defense pathways. Previously, we have shown that IFN-γ–producing cells and LPS, two factors that are associated with severe asthma, induce steroid-resistant AHR in a mouse model. We now demonstrate that cooperative signaling induced by IFN-γ and LPS results in the production of IL-27 by mouse pulmonary macrophages. IL-27 and IFN-γ uniquely cooperate to induce glucocorticoid-resistant AHR through a previously unknown MyD88-dependent mechanism in pulmonary macrophages. Importantly, integrated signaling by IL-27/IFN-γ inhibits glucocorticoid-induced translocation of the glucocorticoid receptor to the nucleus of macrophages. Furthermore, expression of both IL-27 and IFN-γ was increased in the induced sputum of steroid-refractory asthmatics. These results suggest that a potential mechanism for steroid resistance in asthma is the activation of MyD88-dependent pathways in macrophages that are triggered by IL-27 and IFN-γ, and that manipulation of these pathways may be a therapeutic target.
Gene Expression Profiles in a Rabbit Model of Systemic Lupus Erythematosus Autoantibody Production
Authors: Rai Geeta , Ray Satyajit , Milton Jacqueline , Yang Jun , Ren Ping , Lempicki Richard , Mage Rose G. 
Published: September 2010

Abstract
We previously reported the establishment of a rabbit (Oryctolagus cuniculus) model in which peptide immunization led to production of lupus-like autoantibodies including anti-Sm, -RNP, –SS-A, –SS-B, and -dsDNA characteristic of those produced in systemic lupus erythematosus (SLE) patients. Some neurologic symptoms in the form of seizures and nystagmus were observed. The animals used in the previous and in the current study were from a National Institute of Allergy and Infectious Diseases colony of rabbits that were pedigreed, Ig-allotype defined, but not inbred. Their genetic heterogeneity may correspond to that found among patients of a given ethnicity. We extended the information about this rabbit model by microarray-based expression profiling. We first demonstrated that human expression arrays could be used with rabbit RNA to yield information on molecular pathways. We then designed a study evaluating gene expression profiles in eight groups of control and treated rabbits (47 rabbits in total). Genes significantly upregulated in treated rabbits were associated with NK cytotoxicity, Ag presentation, leukocyte migration, cytokine activity, protein kinases, RNA spliceosomal ribonucleoproteins, intracellular signaling cascades, and glutamate receptor activity. These results link increased immune activation with upregulation of components associated with neurologic and anti-RNP responses, demonstrating the utility of the rabbit model to uncover biological pathways related to SLE-induced clinical symptoms, including neuropsychiatric lupus. Our finding of distinct gene expression patterns in rabbits that made anti-dsDNA compared with those that only made other anti-nuclear Abs should be further investigated in subsets of SLE patients with different autoantibody profiles.
Selective Inhibition of the Lectin Pathway of Complement with Phage Display Selected Peptides against Mannose-Binding Lectin-Associated Serine Protease (MASP)-1 and -2: Significant Contribution of MASP-1 to Lectin Pathway Activation
Authors: Kocsis Andrea , Kékesi Katalin A. , Szász Róbert , Végh Barbara M. , Balczer Júlia , Dobó József , Závodszky Péter , Gál Péter , Pál Gábor 
Published: September 2010

Abstract
The complement system, an essential part of the innate immune system, can be activated through three distinct routes: the classical, the alternative, and the lectin pathways. The contribution of individual activation pathways to different biological processes can be assessed by using pathway-selective inhibitors. In this paper, we report lectin pathway-specific short peptide inhibitors developed by phage display against mannose-binding lectin-associated serine proteases (MASPs), MASP-1 and MASP-2. On the basis of the selected peptide sequences, two 14-mer peptides, designated as sunflower MASP inhibitor (SFMI)-1 and SFMI-2, were produced and characterized. SFMI-1 inhibits both MASP-1 and MASP-2 with a KI of 65 and 1030 nM, respectively, whereas SFMI-2 inhibits only MASP-2 with a KI of 180 nM. Both peptides block the lectin pathway activation completely while leaving the classical and the alternative routes intact and fully functional, demonstrating that of all complement proteases only MASP-1 and/or MASP-2 are inhibited by these peptides. In a C4 deposition inhibitor assay using preactivated MASP-2, SFMI-2 is 10-fold more effective than SFMI-1 in accordance with the fact that SFMI-2 is a more potent inhibitor of MASP-2. Surprisingly, however, out of the two peptides, SFMI-1 is much more effective in preventing C3 and C4 deposition when normal human serum containing zymogen MASPs is used. This suggests that MASP-1 has a crucial role in the initiation steps of lectin pathway activation most probably by activating MASP-2. Because the lectin pathway has been implicated in several life-threatening pathological states, these inhibitors should be considered as lead compounds toward developing lectin pathway blocking therapeutics.
Long‐term parental psychological distress among parents of children with a malformation—A prospective longitudinal study
Authors: Skreden Marianne , Skari Hans , Malt Ulrik F. , Haugen Guttorm , Pripp Are H. , Faugli Anne , Emblem Ragnhild 
Published: September 2010

AbstractWe previously reported that prenatal diagnosis of malformations is associated with increased parental psychological distress after birth compared to distress in parents with postnatal diagnosis. We have now extended our earlier study to include a long‐term follow‐up of mothers and fathers 9 years after birth. Psychological responses were measured by General Health Questionnaire (GHQ‐28), State Anxiety Inventory (STAI‐X1), and Impact of Event Scale (IES) in 118 mothers and 100 fathers of 124 children with malformations 0–7 days (T1), 6 weeks (T2), 6 months (T3), and 9 years postpartum (T4). At T4 we observed no significant differences in psychological responses comparing parents with and without prenatal foreknowledge of their child's malformation. At T4 30.2% and 27.8% of the parents reported clinically important psychological distress and clinically important state anxiety, respectively. Intrusive stress decreased from T1 to T3, but increased significantly from T3 to T4. At T4 25.6% of the parents reported severe intrusive stress, with a higher proportion among mothers than fathers (32.8% vs. 17.2%, P = 0.029). In the multivariate analysis, unemployment predicted clinically important psychological distress at T4, whereas, clinically important state anxiety at T4 was predicted by low educational level. This study shows that prenatal diagnosis is associated with significantly increased psychological distress in the acute postnatal phase. However, there was no long‐term increase in psychological distress among parents with prenatal foreknowledge of their child's malformation. The significantly increased intrusive stress at 9‐year follow‐up might reflect long‐term challenges related to having a child with a malformation. © 2010 Wiley‐Liss, Inc.
Russell–Silver syndrome
Authors: Eggermann Thomas 
Published: September 2010

AbstractIn comparison to Prader–Willi or Angelman syndrome, Russell–Silver syndrome (RSS) is a relatively “young” imprinting disorder. This congenital disease is characterized by intrauterine and postnatal growth retardation, relative macrocephaly, a typical triangular face, asymmetry, and further less constant characteristic features. Genetic and epigenetic disturbances can meanwhile be detected in approximately 50% of patients with typical RSS features. Up to 5% of patients carry a maternal uniparental disomy of chromosome 7 (UPD(7)mat), at least 44% show hypomethylation in the chromosome 11p15 imprinting center 1 (IC). In 1–2% of RSS patients, (sub)microscopic chromosomal aberrations can be observed. The diagnostic workup should therefore include methylation/genomic testing for chromosome 11p15, UPD(7)mat analysis and molecular karyotyping. The recurrence risk is generally low in RSS but it can be strongly increased in cases of familial epimutations or a chromosomal rearrangement. Interestingly, in ∼7% of cases with chromosome 11p15 hypomethylation, hypomethylation of additional imprinted loci can be detected. Clinically, patients with hypomethylation at multiple loci do not differ from those with isolated 11p15 hypomethylation whereas the UPD(7)mat patients generally show a milder phenotype. Nevertheless, (epi)genotype–phenotype correlations are still evolving. Furthermore, the pathophysiological mechanisms resulting in the RSS phenotype still remain unknown despite the recent progress in deciphering the molecular defects associated with this condition. © 2010 Wiley‐Liss, Inc.
ChemInform Abstract: Inclusion Compounds of Multi‐Dimensional Cyanometal Complex Hosts
Authors: IWAMOTO T. 
Published: September 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: A New Synthesis of 5‐Substituted 3‐Methyl‐2‐phenylthio‐2‐penten‐5‐ olides.
Authors: SU H. , SHIRAI K. , KUMAMOTO T. 
Published: September 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: General Synthesis of 5,7‐Diaminoimidazo(4,5‐b)pyridine Ribosides (“2‐ Amino‐1‐deazaadenosines”) from 5‐Amino‐4‐imidazolecarboxamide Riboside (AICA Riboside).
Authors: FRANCIS J. E. , MOSKAL M. A. 
Published: September 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Effect of Bi2O3 on Impurity Ion Distribution and Electrical Resistivity of Li‐Zn Ferrites.
Authors: BROOKS K. G. , BERTA Y. , AMARAKOON V. R. W. 
Published: September 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Superconducting and Structural Properties of Strontium‐Substituted YBa2Cu4O8.
Authors: KAREN P. , KJEKSHUS A. , ANDRESEN A. F. 
Published: September 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Effects of Dopants on the Complex Impedance and Dielectric Properties of Aluminum Nitride.
Authors: JANG S.‐A. , CHOI G. M. 
Published: September 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: The Application of 1‐Hydroxyimidazole‐3‐N‐oxides as Aluminum Corrosion Inhibitors in Alkaline Solutions.
Authors: SCHOLL H. , DAVILA JIMENEZ M. M. 
Published: September 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Kinetics of CO Oxidation by N2O Over Rh(111).
Authors: BELTON D. N. , SCHMIEG S. J. 
Published: September 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Electron Microscopic Study of Ultra‐Fine Particles of Silver Resulting from the Electron‐Beam‐Induced Decomposition of Silver Azide.
Authors: HERLEY P. J. , JONES W. 
Published: September 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Low‐Energy Electron Impact Spectroscopy of (1.1.1)Propellane: Electron Attachment Energies and Singlet and Triplet Excited States
Authors: SCHAFER O. , ALLAN M. , SZEIMIES G. , SANKTJOHANSER M. 
Published: September 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Infrared Intensities: Cyclobutene. A Normal‐Coordinate Analysis and Comparison with Cyclopropene.
Authors: WIBERG K. B. , ROSENBERG R. E. 
Published: September 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: IR Intensities: Bicyclo(1.1.1)pentane. A Normal‐Coordinate Analysis and Comparison with (1.1.1)Propellane.
Authors: WIBERG K. B. , ROSENBERG R. E. , WADDELL S. T. 
Published: September 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Variable‐Temperature and ‐Pressure Studies of the Vibrational Spectra and Phase Transition in Quadricyclane.
Authors: KAWAI N. T. , GILSON D. F. R. , BUTLER I. S. 
Published: September 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Supersonic Jet Spectroscopy of N‐(4‐Cyanophenyl)carbazole and Its Complexes
Authors: YU H. , SINCLAIR W. E. , PHILLIPS D. , TANAKA F. 
Published: September 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Effect of Pressure on the Fluorescence of TICT States in (N,N‐ Dimethylamino)benzonitrile and Its Related Compounds
Authors: HARA K. , RETTIG W. 
Published: September 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: A 31P NMR Solution Study of LnAuCl. Comparison of Triphenylphosphine and 5‐Phenyldibenzophosphole Ligands
Authors: ALYEA E. C. , MALITO J. , ATTAR S. , NELSON J. H. 
Published: September 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Ab initio Study of σ‐ and π‐Effects in Benzenes Fused to Four‐ Membered Rings: Rehybridization, Delocalization, and Antiaromaticity.
Authors: FAUST R. , GLENDENING E. D. , STREITWIESER A. , VOLLHARDT K. P. C. 
Published: September 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: α‐Oxygen‐Substituted Organolithium Compounds and Their Carbenoid Nature: Calculations of the Configurational Stability and of LiCH2OH Model Structures, Crystal Structure of Diphenyl(trimethylsilyloxy) methyllithium×3 THF, and the Stereochemistry of the (Reverse) Brook Rearrangement.
Authors: BOCHE G. , OPEL A. , MARSCH M. , HARMS K. , HALLER F. , LOHRENZ J. C. W. , THUEMMLER C. , KOCH W. 
Published: September 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Structure of sp‐9‐Hydroxy‐9‐pivaloylfluorene, Product of Base‐ Catalyzed Autoxidation of ap‐9‐Pivaloylfluorene.
Authors: MEYERS C. Y. , TUNNELL J. L. , ROBINSON P. D. , HUA D. H. , SAHA S. 
Published: September 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Structure of the Antipsychotic Drug 3‐(2‐(4‐(6‐Fluoro‐1,2‐benzisoxazol‐ 3‐yl)‐1‐piperidinyl)ethyl)‐2,9‐dimethyl‐4H‐pyrido(1,2‐a)pyrimidin‐4‐ one (Ocaperidone)
Authors: JOTTIER W. I. , DE WINTER H. L. , PEETERS O. M. , BLATON N. M. , DE RANTER C. J. 
Published: September 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Absolute Configuration of (‐)‐α‐Acetylmethadol Hydrochloride.
Authors: FLIPPEN‐ANDERSON J. L. , GEORGE C. 
Published: September 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Conformational Analysis, Barriers to Internal Rotation, Vibrational Assignment, and ab initio Calculations of 1,2‐Difluoroethane.
Authors: DURIG J. R. , LIU J. , LITTLE T. S. , KALASINSKY V. F. 
Published: September 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Inter‐ and Intramolecular Hetero Diels‐Alder Reactions. Part 41. Unusual Stereocontrol in Intramolecular Hetero Diels‐Alder Reactions of 2‐Aza‐1,3‐butadienes. A Stereoselective Sequential Synthesis of Annulated Tetrahydropyridines.
Authors: TIETZE L. F. , UTECHT J. 
Published: September 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: An Intramolecular Diels‐Alder Reaction of Vinylsilanes.
Authors: SIEBURTH S. MCN. , FENSTERBANK L. 
Published: September 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.