bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Fimbrio‐Ovarian Relation and Its Role on Ovum Picking in Unexplained Infertility: The Fimbrio‐Ovarian Accessibility Tests*
Authors: Ahmad‐Thabet Saeed Mohamad 
Published: May 2010

AbstractObjective: To study the ovum pickup mechanism and the fimbrio‐ovarian relation in fertile women and cases of unexplained infertility and to design a method for investigation and anticipation of the state of ovum pickup.Design: Prospective clinical study.Setting: Department of obstetrics and gynecology Kasr El Aini Hospital, Cairo University, Egypt.Patients: Fifty fertile and 25 cases of unexplained infertility.Interventions: In all of cases the fimbrio‐ovarian relation is studied by determining the length of the free ovarian border between the ovarian ligament and the fimbria ovarica that contains the corpus luteum (the ovulation border), the site of ovulation on that border and the length of the fimbria ovarica. It is also determined by a simple test “The fimbrio‐ovarian accessibility test.” The fimbriae are held by non‐traumatizing grasper and their ability to reach and/or to cover the ovulation site are taken as a prove for successful ovum pickup.In addition, cases having suspected failed ovum picking are treated by controlled supero‐vulation, also by drilling of the ovary at an accessible site to the fimbria ovarica and by freeing short fimbria ovarica with or without its advancement on the ovulation border.Results: The ovulation site is found to be usually accessible to the fimbrial end of the tube (94%) in the fertile cases and not accessible (92%) in the infertile cases. Correction of the fimbrio‐ovarian relation in the infertile cases was associated with a cumulative ongoing pregnancy rate of 68%.Conclusion: Failed ovum pickup should be considered one of the important causes of unexplained infertility. The suggested “fimbrio‐ovarian accessiblity” test may be useful for the elucidation of the state of ovum pickup in infertile cases. Correction of the fimbrio‐ovarian relation, to make ovum pickup possible, should be considered a method for treating such cases.
Bartter's Syndrome in Pregnancy: A Case Report and Review
Authors: Li Ivy C. F. , To William W. K. 
Published: May 2010

AbstractBartter's syndrome is a rare renal tubular disorder, involving juxtaglomerular cells hyperplasia, characterized by normotensive hyper‐reninism and secondary hyperaldosteronism, marked renal loss of potassium and profound hypokalaemia. Both clinical and biochemical features are heterogeneous, ranging from the incidental finding in an asymptomatic patient to marked clinical features of hypokalaemia. Inheritance is likely to be an autosomal recessive. We present a case of Bartter's syndrome complicating pregnancy in a Chinese woman. We documented an increasing demand for potassium supplement during pregnancy which stabilized by mid‐trimester. The absence of pregnancy complications such as polyhydramnios indicated that the fetus was unlikely to be affected by the condition.
Relationship between Endometrial Estrogen and Progesterone Receptors, and Sonographic Endometrial Appearance in the Preovulatory Phase
Authors: Kim Chung‐Hoon , Chae Hee‐Dong , Huh Jooryung , Kang Byung‐Moon , Chang Yoon Seok , Nam Joo‐Hyun 
Published: May 2010

AbstractObjectives: The purpose of the present study is to evaluate the relationship between endometrial concentrations of estrogen receptor (ER) and progesterone receptor (PR), and sonographic endometrial findings in the preovulatory phase of menstrual cycle.Study Design: In 45 cycles of 45 infertile women with tubal factor only, transvaginal sonographic assessments and biopsy for immunohistochemical staining of the endometrium were made in the preovulatory phase of unstimulated, normal menstrual cycle. Immunohistochemical localization of ER and PR was scored according to intensity of staining and proportion of cells specifically stained in glandular epithelium and stroma, and the results were analysed according to the sonographic endometrial thickness (< 6 mm, 6–10 mm, or > 10 mm) and patterns. Endometrial patterns were classified as A, centrally hyperechogenic triple‐line pattern or non‐A, not triple‐line.Results: There were no significant differences in the endometrial thickness, serum estradiol level and serum progesterone level between A and non‐A groups. The receptor scores of epithelial and stromal ER and epithelial PR were comparable in A and non‐A groups. However, the receptor score of stromal PR was significantly higher in A group, with 4.8 ± 1.4 compared with 2.7 + 1.7 in non‐A group (p < 0.001). There were no differences in the receptor scores of epithelial ER, epithelial PR, stromal ER and stromal PR among the 3 groups according to the endometrial thickness.Conclusions: This study suggests that high PR expression in endometrial stroma could be related to the sonographic triple‐line or multilayered pattern of endometrium in the preovulatory period.
A Survey of the Current Practice of Obstetric Anaesthesia and Analgesia in Malaysis
Authors: Chan Y. K. , Ng K. P. 
Published: May 2010

AbstractObjective: A survey covering 30% of the deliveries in Malaysia was done to determine the practice of obstetric anaesthesia and analgesia for 1996.Results: From the survey, it was found that the regional anaesthesia rate for caesarean section was 46% in the government hospitals compared to 29.2% in the private hospitals, with spinal anaesthesia being the most common regional anaesthetic technique used in both types of hospitals. The epidural rate for labour analgesia was only 1.5% overall for the country. Epidural analgesia services were available in all private hospitals whereas 17.6% of government hospitals surveyed did not offer this service at all.Conclusions: Although the use of epidural analgesia for labour was low in Malaysia, the overall rate of regional anaesthesia for caesarean section (41.9%) is very much in keeping with the standards of safe practice recommended by the United Kingdom.
Heavy‐for‐Date Infants: Their Backgrounds and Relationship with Gestational Diabetes
Authors: Hiramatsu Yuji , Masuyama Hisashi , Mizutani Yasushi , Kudo Takafumi , Oguni Nobutugu , Oguni Yoshitane 
Published: May 2010

AbstractObjective: Gestational diabetes (GDM) is closely related to birth weight. Heavy‐for‐date (HFD) infants, especially those with macrosomia, cause many perinatal complications. This study was performed to examine the backgrounds of HFD infants and to determine such infants' relationship with GDM.Method: Eighty cases of HFD infants who were delivered from 1996 through 1998 were analyzed. The random blood‐glucose level was used for screening for GDM.Results: Maternal body weight and the body‐mass index before pregnancy and at delivery and the blood glucose level at the second trimester were positively correlated with birth weight. However, only 8.8% of HFD cases were detected by this screening method in the first trimester, and 11.3% of HFD cases were detected in the second trimester and only 1 case of borderline‐type was detected by subsequent 75‐g OGTT.Conclusions: Maternal obesity is an independent and more important risk factor for HFD infants than glucose intolerance.
Adverse Pregnancy Outcome Following Post‐Chorionic Villus Sampling Amniocentesis Compared to Chorionic Villus Sampling
Authors: Kim Sei K. , Cho Dong J. , Kim Jae W. , Chung Jae E. , Yang Young H. 
Published: May 2010

AbstractObjective: To assess the adverse pregnancy outcome of post‐chorionic villus sampling (CVS) amniocentesis and chorionic villus sampling.Methods: Adverse pregnancy outcomes of 32 post‐CVS amniocentesis cases and 264 CVS only cases were compared. The base‐line characteristics were comparable in the 2 groups.Results: One (3.1%) chromosomal abnormality was detected in the post‐CVS amniocentesis group, compared to 5 (1.8%) in the CVS only group (p > 0.05). The fetal loss rate (spontaneous abortions and stillbirths) among continuing pregnancies was 3.2% in the post‐CVS amniocentesis group and 3.5% in the CVS only group (p > 0.05). No statistically significant difference was found in the incidence of neonatal death, preterm delivery, fetal growth restriction, or congenital anomalies between the 2 groups.Conclusion: Adverse pregnancy outcome occurred at a similar frequency in the post‐CVS amniocentesis group as in the CVS only group. Therefore, a subsequent amniocentesis after CVS can be considered as a safe procedure that does not introduce any additional adverse pregnancy outcome compared to that of CVS only.
Antenatal Use of Ambroxol for the Prevention of Infant Respiratory Distress Syndrome
Authors: Laoag‐Fernandez Jovelle B. , Fernandez Alex M. , Maruo Takeshi 
Published: May 2010

AbstractObjective: Our purpose was to evaluate the efficacy and safety of ambroxol for the prenatal prophylaxis of infant respiratory distress syndrome (IRDS).Study Design: This was a prospective study with 2 groups of pregnant patients with premature labor or with premature rupture of membranes at an estimated gestation between 27 to 34 completed weeks. Ambroxol treatment group consisted of 39 subjects in whom 1,000 mg of ambroxol diluted in 500 ml of 5% glucose solution was given intravenously for 4 hours once a day for 3 days, while the control group consisted of 41 subjects in whom ambroxol was not administered. Main measures included Apgar scores, clinical signs of one or more of the following: respiratory rate of > 60/min, intercostal retraction, alar flaring, expiratory grunting, cyanosis on room air and radiological evidence of IRDS. Chi‐square test was used to determine the statistical significance of the results.Results: Tolerable maternal side effects were noted. Profile of newborns delivered were similar in both groups. Incidence of IRDS was significantly less in the treatment group (p < 0.01).Conclusions: Antenatal administration of ambroxol resulted in a significant decrease in the incidence of IRDS as well as perinatal morbidity and mortality. Due to the efficacy and safety of this drug, it might be useful for the prevention of IRDS.
Epidemic of Cesarean Section at the General, Private and University Hospitals in Thailand
Authors: Chanrachakul Boonsri , Herabutya Yongyoth , Udomsubpayakul Umaporn 
Published: May 2010

AbstractObjective: To undertake a survey of cesarean section in the general, private and university hospitals in Thailand.Methods: Postal questionnaires were sent to all the general, private and university hospitals with 200 beds or more. The questionnaires were prepared to find out the percentage, the indications and the trend of cesarean delivery, the measures taken to decrease cesarean section rate, and the practice of external cephalic version (ECV) and vaginal birth after cesarean section (VBAC) in the hospitals.Results: The overall response rate was 88%. Mean cesarean section rates were 24, 48, and 22% in the general, private and university hospitals, respectively. Cesarean section rates in most of the hospitals were increased in the past 5 years namely 78% in the general hospitals, 50% in the private hospitals, 66% in the university hospitals. However, only 38% of the hospitals had measures to regulate this operation. Repeated cesarean section was the most common indication in the private (63%) and the university hospitals (88%) while failure to progress was the most common indication in the general hospitals (55%). ECV and VBAC were performed in 26 and 12% of the hospitals. They were, however, not the standard practices.Conclusion: Rising of cesarean section rate without any measure to regulate it is the problem in the developing countries. Standardised labor management and reduction of unnecessary primary cesarean section will automatically reduce repeated operation and overall cesarean section.
Reference Intervals for First Trimester Embryonic/Fetal Heart Rate in a Thai Population
Authors: Tannirandorn Yuen , Manotaya Saknan , Uerpairojkit Boonchai , Tanawattanacharoen Somchai , Wacharaprechanont Teera , Charoenvidhya Dhiraphongs 
Published: May 2010

AbstractObjective: To establish reference intervals for first trimester embryonic/fetal heart rate in a Thai population.Methods: A prospective descriptive cross‐sectional study was performed on normal pregnant women registered at the antenatal clinic in their first trimester. All had a good menstrual history and the calculated gestational age using crown‐rump length (CRL) in the first trimester ultrasound was in agreement. Crown‐rump length and embryonic/fetal heart rate measurements were obtained by a 5 MHz vaginal probe combined with a duplex color Doppler machine. All of the newborns were proved to be normal at birth. We constructed and compared embryonic/fetal heart rate expressed as beats/min relating to gestational age (GA) (days) and CRL. The data was analyzed and the best fit mathematical model was derived using the SPSS computer program.Results: 547 cases were enrolled into the study. The median embryonic/fetal heart rate increased from 124 beats/min at GA of 40–44 days to 177 beats/min at GA 60–64 days, thereafter, embryonic/fetal heart rate gradually decreased to 159 beats/min at GA 95–99 days. The best fit regression equation was: embryonic/fetal heart rate (beats/min) = ‐ 21.666 + 5.4796 GA (day) ‐ 0.0383 GA (day)2, R = 0.5, p < 0.0001). In addition, embryonic/fetal heart rate also correlated with CRL. The median embryonic/fetal heart rate increased from 131 beats/min at CRL of 5–9 mm to 177 beats/min at CRL 20–34 mm, thereafter, embryonic/fetal heart rate gradually decreased to 155 beats/min at CRL 75–79 mm. The best fit regression equation was: embryonic/fetal heart rate (beats/min) = 127.361 + 3.4939 CRL (mm) ‐ 0.0749 CRL (mm)2 + 0.0004 CRL (mm)3, R = 0.58, p < 0.0001).Conclusion: Reference intervals for first trimester embryonic/fetal heart rate in a Thai population were established. Our reference intervals may be useful for further studies, such as the prediction of spontaneous abortion or chromosomal disorders after ultrasound‐proven viability in the first trimester.
Laparoscopic Surgery for Endometriosis: A Long Term Follow‐Up
Authors: Tokushige Makoto , Suginami Hiroshi , Taniguchi Fumiaki , Kitaoka Yuki 
Published: May 2010

AbstractObjective: To investigate if complete resolution of endometriosis by laparoscopic surgery is beneficial to postoperative fecundity, dysmenorrhea and dyspareunia.Design: An observational comparative study on the outcome of laparoscopic surgery.Patients: Laparoscopically‐treated symptomatic women with endometriosis (total n = 236); complete (n = 185) and incomplete (n = 51) surgery groups.Measurements: Postoperative fecundity and symptom reduction.Results: With whole populations, no surgical completeness‐related difference was observed in cumulative pregnancy rates during the postoperative days 0–400 (cycle fecundity rate = 0.0319). Further accumulation of pregnant cases was followed in the complete surgery group (final cumulative pregnancy rate = 80%), but not in the counterpart group (p = 0.003). The similar result was obtained when only r‐AFS classification stages III and IV were compared (p = 0.007). No r‐AFS stage‐related difference was observed in cumulative pregnancy rates when only patients of complete surgery were selected for comparison. The surgery reduced dysmenorrhea (84.7%) and dyspareunia (80.0%).Conclusions: Laparoscopic conservative surgery for endometriosis, especially when it is complete, increases fecundity and reduces disease‐related symptoms, such as dysmenorrhea and dyspareunia.
Neurogenic Cyst of Ovary: An Unusual Massive Monodermal Teratoma
Authors: Sah S. Prasad , Verma Kavita , Rani Sudha 
Published: May 2010

AbstractAn unusual massive benign cystic monodermal teratoma of the ovary in a 14‐year‐old girl is reported. The multilocular cyst measured 80 times 70 times 80 cm and contained 23 / of fluid. The cyst wall composed of purely mature central nervous system tissue with a prominent microvasculature resting on a thin rim of ovarian cortical tissue. Immunohistochemical stains supported the diagnosis. To the best of our knowledge only one such case has been described in the literature.
Recent Advancements in the Treatment of Epithelial Ovarian Cancer*
Authors: DiSaia Philip J. , Tewari Krishnansu S. 
Published: May 2010

AbstractImportant advances in the management of advanced epithelial ovarian cancer have been made in recent years, with much of the knowledge emanating from clinical trials conducted by the Gynecological Oncology Group (GOG). This monograph reviews the trials that have defined current clinical practice and summarizes some innovative techniques and promising new drugs for the future
Umbilical Vein Thrombosis as a Possible Cause of Perinatal Morbidity or Mortality: Report of Two Cases
Authors: Minakami Hisanori , Akahori Akiko , Sakurai Shinji , Yamauchi Ariko , Sato Ikuo 
Published: May 2010

AbstractSignificant occlusion of the lumen of the umbilical vein by thrombus was observed in 2 patients with unexplained intrauterine fetal death (IUFD)/fetal distress. Although a normal non‐stress testing result was obtained 7 days prior to IUFD in one patient, IUFD was noted during regular antenatal care at 39 weeks of gestation; intrapartum abrupt onset of deceleration in fetal heart rate pattern was observed at 40 weeks of gestation, lasting 14 min until vacuum extractor‐assisted delivery in the other patient. Umbilical vein thrombosis was considered contributory to IUFD and the abrupt deterioration in fetal heart rate pattern in these 2 patients. Histological examination of the umbilical cord is thus important in unexplained fetal death/fetal distress.
Glassy Cell Carcinoma of the Uterine Cervix: Combination Chemotherapy with Paclitaxel and Carboplatin in Recurrent Tumor
Authors: Matsuura Yusuke , Murakami Nobuko , Nagashio Eiji , Toki Naoyuki , Kashimura Masamichi 
Published: May 2010

AbstractCombination chemotherapy with paclitaxel and carboplatin every 4 weeks for 3 cycles was administered for recurrent glassy cell carcinoma of the uterine cervix in a 67‐year‐old Japanese female. The response rate was 56% under computed tomography (partial response). However, the effect was transient even with follow‐up radiotherapy, and further cases need to be accumulated to determine a successful treatment modality.
Maternal Mortality in Rural India: A Hospital Based, 10 Year Retrospective Analysis
Authors: Verma Kavita , Thomas Abraham , Sharma Arun , Dhar Aruna , Bhambri Vishal 
Published: May 2010

AbstractObjectives: To estimate the maternal mortality ratio (MMR) in Ludhiana, a city of Northern India in order to determine the causes associated with MMR and to suggest ways to reduce it.Methods: Retrospective analysis of the mortality records of obstetrics cases in Christian Medical College, Ludhiana, India.Results: The mean MMR for the 10 year period was 785 per 100,000 live births. Of the total 116 reported maternal deaths, 44 (41.9%) were due to induced septic abortion. The reasons were unwanted pregnancy in 22 (50%) and 11 (25%) were female feticide.Conclusions: In our hospital based analysis, MMR was very high. Most maternal deaths are preventable by intervention at the appropriate time and it is important for health professionals, policy makers and politicians to implement the introduction of programs for reducing maternal mortality. Special emphasis should be placed on antenatal care, the establishment of a registration system and measures to abolish illegal abortion.
Angiosarcoma of Vagina Successfully Treated with Interleukin‐2 Therapy and Chemotherapy: A Case Report
Authors: Morimura Yutaka , Hashimoto Toshihiro , Soeda Shu , Fujimori Keiya , Yamada Hidekazu , Yanagida Kaoru , Sato Akira 
Published: May 2010

AbstractWe report a case of angiosarcoma of the vagina in a 61‐year‐old woman who had undergone radical hysterectomy and pelvic irradiation for uterine cervical adenocarcinoma 14 years previously. Combination chemotherapy (cyclophosphamide, vincristine, doxorubicin and dacarbazine) and interleukin‐2 induced complete remission of the tumor. The patient remained free from disease for 15 months.
Transfer of Two Embryos Instead of Three Will not Compromise Pregnancy Rate but Will Reduce Multiple Pregnancy Rate in an Assisted Reproduction Unit
Authors: Ng Ernest Hung Yu , Lau Estella Yee Lan , Yeung William Shu Biu , Ho Pak Chung 
Published: May 2010

AbstractObjectives: To compare the pregnancy rates and multiple pregnancy rates of cycles initiated in 1998 and in 1999, during which 3 and 2 embryos were advised to be replaced, respectively.Study design: A retrospective studyResults: There were no differences between 1998 and 1999 in the pregnancy rate per cycle started or per transfer, implantation rate and the multiple pregnancy rates, despite a significantly lower number of embryos replaced in 1999. A significantly higher implantation rate was found in cycles with frozen embryos than those without. Using logistic regression analysis, the chance of pregnancy was significantly improved only by the presence of frozen embryos in the fresh cycles with an odds ratio of 2.0 (95% confidence interval: 1.3‐3.0) whereas the chance of multiple pregnancy was significantly increased by replacing 3 embryos instead of 2 (odds ratio: 2.1, 95% confidence interval: 1.1–4.2).Conclusion: Patients should be advised to have 2 embryos replaced without jeopardizing the pregnancy rates in the fresh cycles. The risk of multiple pregnancy is significantly increased when 3 embryos are transferred instead of 2.
The Relation between Plasma Homocysteine Concentration and Methylenetetrahydrofolate Reductase Gene Polymorphism in Pregnant Women
Authors: Murakami Soh , Matsubara Naoko , Saitoh Masahiro , Miyakawa Sohei , Shoji Makoto , Kubo Takeshi 
Published: May 2010

AbstractObjectives: Our purpose was to clarify the influence of methylenetetrahydrofolate reductase (MTHFR) gene polymorphism on plasma homocysteine (Hcy) concentrations during early pregnancy.Methods: Between 1996 and 1998, Hcy concentration and MTHFR gene polymorphism were studied in 840 pregnant women between 6 to 12 weeks' gestation. Hcy concentration was measured by amino acid autoanalyzer (DLC‐300, Nihon Denshi), and MTHFR genotypes were determined by the PCR/RFLP methods. Pregnancy outcomes were compared in association with Hcy concentration and MTHFR genotypes.Results: A total of 816 of the 840 women were enrolled into the study because MTHFR genotypes were not available in 24 women. Genotypes of C677T in the MTHFR gene were CC: CT: TT (%) = 280 (34.3): 400 (49.0): 136 (16.7). Plasma Hcy concentration was significantly (p < 0.0001) higher in women with TT genotype than other genotypes [CC: CT: TT = 5.67 (2.8–10.6): 5.80 (2.5–20.1): 6.91 (3.5–20.9) nmol/ml, median (range)]. Women with hyperhomo‐cysteinemia had severe preeclampsia (2 of 35 vs 5 of 714, p < 0.01) and stillbirth (2 of 35 vs 10 of 714, p < 0.05) more frequently than normohomocysteinemia.Conclusions: Plasma Hcy concentration during early pregnancy was higher in women with homozygote for the T677 allele in the MTHFR gene than other genotypes.