bluuebunny/crossref_metadata_2025_split huggingface dataset:
5. A Comparison to Game Theory
Authors: Richter Michael , Rubinstein Ariel 
Published: April 2024

In the final chapter, we compare this book's modeling approaches with each other and to those of standard Game Theory on two ``battlegrounds''.
The first is the matching economy. An even-sized population of agents must match into exclusive pairs (pairings). Each agent possesses a preference relation over potential mates.
The standard cooperative game theory solution concept for matching economies is ``pairwise stability''. Following Richter and Rubinstein (2024), we compare this concept with the jungle equilibrium, the Y-equilibrium and the status and initial status equilibrium concepts.
The second battleground is a ``political economy'' situation. A group of agents hold views on a political issue. Each agent chooses a position and has preferences only regarding the position he himself chooses (and not the choices of others). However, there is a need that a majority of agents choose the same position.
Traditionally, such a situation is modeled as a non-cooperative game and its Nash equilibria are calculated. Extending Richter and Rubinstein (2021), we compare this approach with the convex Y-equilibrium and the biased preferences equilibria.
On both battlegrounds, the new approaches lead to very different outcomes than the traditional ones.
Combining Temperature and Precipitation to Constrain the Aerosol Contribution to Observed Climate Change
Authors: Roesch Carla M. , Ballinger Andrew P. , Schurer Andrew P. , Hegerl Gabriele C. 
Published: April 2024

Abstract
Using the past to improve future predictions requires an understanding and quantification of the individual climate contributions to the observed climate change by aerosols and greenhouse gases (GHGs), which is hindered by large uncertainties in aerosol forcings and responses across climate models. To estimate historical aerosol responses, we apply detection and attribution methods to attribute a joint change in temperature and precipitation to forcings by combining signals of observed changes in tropical wet and dry regions, the interhemispheric temperature asymmetry, global mean temperature (GMT), and global mean land precipitation (GMLP). Fingerprints representing the climate response to aerosols (AERs) and the remaining external forcings (noAER; mostly GHG) are derived from large ensembles of historical single- and ALL-forcing simulations from three models in phase 6 of the Coupled Model Intercomparison Project and selected using a perfect model study. Results from an imperfect model study and a hydrological sensitivity analysis support combining our choice of temperature and precipitation fingerprints into a joint study. We find that diagnostics including temperature and precipitation slightly better constrain the noAER signal than diagnostics based purely on temperature or GMT-only and allow for the attribution of AER cooling (even when GMT is not included in the fingerprint). These results are robust across fingerprints from different climate models. Estimated contributions for AER and noAER agree with other published estimates including those from the most recent IPCC report. Finally, we attribute the best estimate of 0.46 K ([−0.86, −0.05] K) of aerosol-induced cooling and 1.63 K ([1.26, 2.00] K) of noAER warming in 2010–19 relative to 1850–1900 using the combined signals of GMT and GMLP.

Significance Statement
Aerosols are small liquid or solid airborne particles. They are predominantly the secondary result of emissions of aerosol precursor gases emitted via industrial or natural processes. While greenhouse gases warm the climate, aerosols can have a cooling effect on the climate system, thus offsetting some of the greenhouse gas–related warming. We expect greenhouse gas concentrations in the atmosphere to continue to increase, while aerosol concentrations are likely going to decline due to their impacts on human health. Our study uses observed temperature and precipitation changes to quantify how much aerosols have offset warming from past greenhouse gas emissions. This can help constrain future predictions of global warming.
Top-Down Phenomenon Observed in the Outer Rainbands of Typhoon Maysak (2020): Insights from the Comparative Analysis of Cloud and Precipitation Microphysics with a Typical Precipitation Event in Northeast China
Authors: Liu Tianao , Chen Yilun , Zuo Haosheng , Zhang Aoqi , Pan Xiao , Chen Shumin , Li Weibiao 
Published: April 2024

Abstract
Cloud and precipitation microphysics in tropical cyclones (TCs) moving toward Northeast China may exhibit significant distinctions compared with the typical precipitation of this region. In this study, observations from ground-based particle size velocity (Parsivel) disdrometers in Liaoning Province, China, and cloud property data from the Himawari geostationary satellite were utilized to analyze the raindrop size distribution (DSD) characteristics and cloud vertical evolution associated with the outer rainbands of Typhoon Maysak (2020). A comparative analysis was conducted with a typical precipitation event in Northeast China induced by a cold vortex (cold-core low). Our findings reveal distinctive DSD characteristics related to the TC, where medium-sized raindrops dominate, with a smaller diameter but higher concentration in the TC case compared to the typical cold-vortex-induced precipitation case in Northeast China. Convective precipitation falls between maritime-like and continental-like patterns, leaning more toward continental convection. This varies significantly with TCs in Southeast China but is similar to that observed in coastal-front-like rainbands, suggesting extratropical influence. A detailed analysis of the vertical profile of cloud droplets shows a unique “top-down” phenomenon during the extratropical transition process of the TC, where the development of lower-level clouds follows that of upper-level clouds, inconsistent with previous studies and the case for comparison. Further investigation indicates the significant role of the intrusion of dry and cold air from upper levels and the presence of high humidity in low levels in driving this phenomenon. Our results will provide novel insights into cloud and precipitation microphysics associated with TCs in midlatitude regions.
Comparing Accuracy of Night Radiology Interpretations for Pediatric Trauma: Radiology Residents Versus Attending Teleradiologists
Authors: Martino Alice M. , Yeates Eric O. , Grigorian Areg , Chinn Justine , Young Hayley , Colin Escobar Jessica , Glavis-Bloom Justin , Anavim Arash , Yaghmai Vahid , Nguyen Ninh T. , Dolich Matthew , Schubl Sebastian D. , Goodman Laura F. , Guner Yigit S. , Nahmias Jeffry 
Published: April 2024

Background: Overnight radiology coverage for pediatric trauma patients (PTPs) is addressed with a combination of on-call radiology residents (RRs) and/or attending teleradiologists (ATs); however, the accuracy of these two groups has not been investigated for PTPs. We aimed to compare the accuracy of RRs vs AT interpretations of computed tomography (CT) scans for PTPs. Methods: Pediatric trauma patients (<18 years old) at a single level-I adult/level-II pediatric trauma center were studied in a retrospective analysis (3/2019-5/2020). Computed tomography scans interpreted by both RRs and ATs were included. Radiology residents were compared to ATs for time to interpretation (TTI) and accuracy compared to faculty attending radiologist interpretation, using the validated RADPEER scoring system. Additionally, RR and AT accuracies were compared to a previously studied adult cohort during the same time-period. Results: 42 PTPs (270 interpretations) and 1053 adults (8226 interpretations) were included. Radiology residents had similar rates of discrepancy (13.3% vs 13.3%), major discrepancy (4.4% vs 4.4%), missed findings (9.6% vs 12.6%), and overcalls (3.7% vs .7%) vs ATs (all P > .05). Mean TTI was shorter for RRs (55.9 vs 90.4 minutes, P < .001). Radiology residents had a higher discrepancy rate for PTPs (13.3% vs 7.5%, P = .01) than adults. Attending teleradiologists had a similar discrepancy rate for PTPs and adults (13.3% vs 8.9%, P = .07). Discussion: When interpreting PTP CT imaging, RRs had similar discrepancy rates but faster TTI than ATs. Radiology residents had a higher discrepancy rate for PTP CTs than RR interpretation of adult patients, indicating both RRs and ATs need more focused training in the interpretation of PTP studies.
Deaths After Readmissions are Mostly Attributable to Failure-to-Rescue in EGS Patients
Authors: Coimbra Raul , Kim Maru , Allison-Aipa Timothy , Zakhary Bishoy , Kwon Junsik , Firek Matthew , Coimbra Bruno Cammarota , Costantini Todd W. , Haynes Laura N. , Edwards Sara B. 
Published: April 2024

Introduction We have recently shown that readmission after EGS procedures carries a 4-fold higher mortality rate when compared to those not readmitted. Understanding factors associated with death after readmission is paramount to improving outcomes for EGS patients. We aimed to identify risk factors contributing to failure-to-rescue (FTR) during readmission after EGS. We hypothesized that most post-readmission deaths in EGS are attributable to FTR. Methods A retrospective cohort study using the NSQIP database 2013-2019 was performed. Patients who underwent 1 of 9 urgent/emergent surgical procedures representing 80% of EGS burden of disease, who were readmitted within 30 days post-procedure were identified. The procedures were classified as low- and high-risk. Patient characteristics analyzed included age, sex, BMI, ASA score comorbidities, postoperative complications, frailty, and FTR. The population was assessed for risk factors associated with mortality and FTR by uni- and multivariate logistic regression. Results Of 312,862 EGS cases, 16,306 required readmission. Of those, 10,748 (3.4%) developed a postoperative complication. Overall mortality after readmission was 2.4%, with 90.6% of deaths attributable to FTR. Frailty, high-risk procedures, pulmonary complications, AKI, sepsis, and the need for reoperation increased the risk of FTR. Discussion Death after a complication is common in EGS readmissions. The impact of FTR could be minimized with the implementation of measures to allow early identification and intervention or prevention of infectious, respiratory, and renal complications.
Paradigm Shifts in Vascular Surgery: Analysis of the Top 100 Innovative and Disruptive Academic Publications
Authors: Gallagher Shea , Vojvodic Vanya , Dilday Joshua , Park Stephen , Ugarte Chaiss , McGillen Patrick , Plotkin Anastasia , Magee Gregory A. , Inaba Kenji , Martin Matthew 
Published: April 2024

Background Disruption score (DS) is a novel bibliometric created to identify research that shifts paradigms, which may be overlooked by citation count (CC). We analyzed the most disruptive, compared to the most cited, literature in vascular surgery, and hypothesized that DS and CC would not correlate. Methods A PubMed search identified vascular surgery publications from 1954 to 2014. The publications were linked to the iCite NIH tool and DS algorithm to identify the top 100 studies by CC and DS, respectively. The publications were reviewed for study focus, design, and contribution, and subsequently compared. Results A total of 56,640 publications were identified. The top 100 DS papers were frequently published in J Vasc Sur (43%) and Eur J Vasc Endovasc Surg (13%). The top 100 CC papers were frequently published in N Engl J Med (32%) and J Vasc Sur (20%). The most cited article is the fifth most disruptive; the most disruptive article is not in the top 100 cited papers. The DS papers had a higher mean DS than the CC papers (.17 vs .0001, P < .0001). The CC papers had a higher mean CC than the DS papers (866 vs 188, P < .0001). DS and CC are weakly correlated metrics (r = .22, P = .03). Discussion DS was weakly correlated with CC and captured a unique subset of literature that created paradigm shifts in vascular surgery. DS should be utilized as an adjunct to CC to avoid overlooking impactful research and influential researchers, and to measure true academic productivity.
‘How long do you think?’ Unresponsive dying patients in a specialist palliative care service: A consecutive cohort study
Authors: O’Connor Tricia , Liu Wai-Man , Samara Juliane , Lewis Joanne , Paterson Catherine 
Published: April 2024

Background: Predicting length of time to death once the person is unresponsive and deemed to be dying remains uncertain. Knowing approximately how many hours or days dying loved ones have left is crucial for families and clinicians to guide decision-making and plan end-of-life care. Aim: To determine the length of time between becoming unresponsive and death, and whether age, gender, diagnosis or location-of-care predicted length of time to death. Design: Retrospective cohort study. Time from allocation of an Australia-modified Karnofsky Performance Status (AKPS) 10 to death was analysed using descriptive narrative. Interval-censored survival analysis was used to determine the duration of patient’s final phase of life, taking into account variation across age, gender, diagnosis and location of death. Setting/participants: A total of 786 patients, 18 years of age or over, who received specialist palliative care: as hospice in-patients, in the community and in aged care homes, between January 1st and October 31st, 2022. Results: The time to death after a change to AKPS 10 is 2 days ( n = 382; mean = 2.1; median = 1). Having adjusted for age, cancer, gender, the standard deviation of AKPS for the 7-day period prior to death, the likelihood of death within 2 days is 47%, with 84% of patients dying within 4 days. Conclusion: This study provides valuable new knowledge to support clinicians’ confidence when responding to the ‘how long’ question and can inform decision-making at end-of-life. Further research using the AKPS could provide greater certainty for answering ‘how long’ questions across the illness trajectory.
Long-term incidence, risk factors and complications for venous thromboembolism in patients with systemic lupus erythematosus
Authors: Nossent Johannes Cornelis , Keen Helen Isobel , Preen David Brian , Inderjeeth Charles Anoukpar 
Published: April 2024

Aim To compare frequency, incidence rates (IR), risk factors and outcomes of a first venous thromboembolic event (VTE) between patients with systemic lupus erythematosus (SLE) and controls. Methods Using state-wide longitudinal hospital data from Western Australia (WA), we recorded venous thrombosis (VT) and pulmonary embolism (PE) in patients with SLE ( n = 1854, median age 40, 86% female) and matched hospitalised controls ( n = 12,107, median age 40 years, females 88.6%) in the period 1985–2015. Results presented are medians, frequency, IR per 1000 person years (PY) and odds, rate, or adjusted hazard ratios (OR/RR/a-HR) with 95% confidence intervals (CI). Results Patients with SLE had significantly higher odds (12.8 vs 3.3%; OR 4.26, CI 3.60–5.05) and IR for a first VTE (10.09 vs 1.52; RR 6.64; CI 5.56–7.79). Over the three study decades, the IR for PE declined in patients with SLE from 7.74 to 3.75/1000 PY ( p < .01) with no changes observed for VT or in controls. VTE recurred more frequently in patients with SLE (24.1% vs 10.2 %) ( p < .01). Antiphospholipid antibodies (aPL) (a-HR 4.24, CI 2.50–7.19), serositis (a-HR 2.70, CI 1.86–3.91), lupus nephritis (a-HR 1.75 CI 1.25–2.33) and thrombocytopenia (a-HR 1.65 (1.10–2.49) were the strongest disease risk factors for VTE only in patients with SLE, while arterial hypertension, smoking and obesity were independent VTE risk factors for both groups. VTE was not associated with an increased risk for arterial events, but PE increased the risk for pulmonary hypertension (PH) in both patients with SLE (a-HR 6.47, CI 3.73–11.23) and controls (a-HR 9.09, CI 3.50–23.63). VTE increased the risk of death in both patients with SLE (a-HR 2.02, CI 1.50–2.70) and controls (a-HR 6.63, CI 5.21–8.42) after 10 years of follow-up. Conclusions VTE affected 12.8% of patients with SLE at six times the VTE rate in controls with aPL as the strongest, but not the only risk factor in SLE. The risk of PH was increased in both groups following PE, but VTE did not associate with an increased risk of arterial events.
Nirsevimab: Expansion of Respiratory Syncytial Virus Prevention Options in Neonates, Infants, and At-Risk Young Children
Authors: Fly J. Hunter , Eiland Lea S. , Stultz Jeremy S. 
Published: April 2024

Objective: Review available data from clinical trials of nirsevimab for efficacy and safety in the setting of respiratory syncytial virus (RSV) prophylaxis in infants and children, while exploring nirsevimab’s role in clinical practice and highlighting continuing questions. Data sources: A literature search of PubMed was conducted utilizing the phrases “nirsevimab” and “medi8897.” Additional references were identified through found references. Organizational guidelines, medication labeling, and regulatory organization presentations were utilized. Study selection and data extraction: Relevant clinical trials investigating nirsevimab in infants and children were included as well as other references on pharmacology, pharmacokinetics, and pharmacoeconomics. Data synthesis: Nirsevimab, a once-a-season monoclonal antibody, demonstrated a 79.5% (95% CI, 65.9-87.7; P < 0.00001) lower incidence of RSV-associated medically attended lower respiratory tract infections (MA RSV-associated LRTI) and 77.3% (95% CI, 50.3-89.7; P = 0.0002) reduction in hospitalizations for RSV-associated MA-LRTI across 2 placebo-controlled studies. Nirsevimab demonstrated comparable safety to placebo with minor dermatologic reactions being the most common adverse event (0.9% vs 0.6%). Relevance to patient care and clinical practice in comparison with existing agents: Nirsevimab was approved by the US Food and Drug Administration, and recommended by the Advisory Committee on Immunization Practices and American Academy of Pediatrics for broad administration to infants entering their first RSV season and at risk patients during their second RSV season. Questions remain over efficacy in infants born < 29-week gestation and other economical considerations. Conclusions: Nirsevimab demonstrated clinical efficacy in reducing RSV-associated MA-LRTI and RSV-associated hospitalizations in infants and was well tolerated.
Investigating the impact of empagliflozin on the retina of diabetic mice
Authors: Chen Juan , Zhang Shenghui , You Yao , Hu Siqi , Tang Jiake , Chen Chen , Wen Wen , Tang Ting , Yu Qingwen , Tong Xuhan , Wang Chunyi , Zhao Wenbin , Fu Xinyan , Zhang Xingwei , Wang Mingwei , Gong Wenyan 
Published: April 2024

Background Diabetic retinopathy (DR) frequently results in compromised visual function, with hyperglycemia-induced disruption of the blood-retinal barrier (BRB) through various pathways as a critical mechanism. Existing DR treatments fail to address early and potentially reversible microvascular alterations. This study examined the effects of empagliflozin (EMPA), a selective Sodium-glucose transporter 2 (SGLT2) inhibitor, on the retina of db/db mice. The objective of this study is to investigate the potential role of EMPA in the prevention and delay of DR. Methods db/db mice were randomly assigned to either the EMPA treatment group (db/db + Emp) or the model group (db/db), while C57 mice served as the normal control group (C57). Mice in the db/db + Emp group received EMPA for eight weeks. Body weight, fasting blood glucose (FBG), and blood VEGF were subsequently measured in all mice, along with the detection of specific inflammatory factors and BRB proteins in the retina. Retinal SGLT2 protein expression was compared using immunohistochemical analysis, and BRB structural changes were observed via electron microscopy. Results EMPA reduced FBG, blood VEGF, and retinal inflammatory factors TNF-α, IL-6, and VEGF levels in the eye tissues of db/db mice. EMPA also increased Claudin-1, Occludin-1, and ZO-1 levels while decreasing ICAM-1 and Fibronectin, thereby preserving BRB function in db/db mice. Immunohistochemistry revealed that EMPA reduced SGLT2 expression in the retina of diabetic mice, and electron microscopy demonstrated that EMPA diminished tight junction damage between retinal vascular endothelial cells and prevented retinal vascular basement membrane thickening in diabetic mice. Conclusion EMPA mitigates inflammation and preserves BRB structure and function, suggesting that it may prevent DR or serve as an effective early treatment for DR.
Implementation of a Mindful Walking Intervention in Breast Cancer Patients After Their Primary Oncologic Treatment: Results of a Qualitative Study Within a Randomized Controlled Trial
Authors: Ortiz Miriam , Schröder Maren Luise , Brinkhaus Benno , Stöckigt Barbara 
Published: April 2024

Background: Breast cancer survivors often suffer from diagnosis- and therapy-related long-term side effects, such as cancer related fatigue, restricted stress resilience and quality of life. Walking as a physical activity and mindfulness practice have been shown to be helpful in studies. The aim of this study was to compare the individual experiences and subjectively perceived effects of walking in combination with mindfulness practice with moderate walking alone in breast cancer patients. This paper focuses on the qualitative results of a mixed-methods pilot study. Methods: Breast cancer patients who had finished their primary oncologic treatment at least 6 months ago were randomized to an 8-week group intervention program of either mindful walking or moderate walking. Within the qualitative study part, semi-structured focus group interviews (2 interviews per study arm) were conducted and analyzed using a qualitative content analysis approach. Audio recorded interviews were transcribed verbatim and pseudonymized. The subsequent data analysis was performed by using MAXQDA®. Results: A total of 51 women (mean age 55.8 [SD 10.9] years) were included in the RCT, among these 20 (mean age 56.7 [SD 12.0] years) participated in the focus group interviews (n = 11 patients of the mindful walking group; n = 9 patients of the walking group). Breast cancer patients in both groups described different effects in the complex areas of self-efficacy, coping, body awareness and self-reflection. While mindful walking primarily promoted body awareness and inner strength by mindfulness in breast cancer patients, moderate walking promoted self-efficacy by a confidence of their body and an easily integrated and accepted way of physical activity. Conclusions: Study interventions and the study setting triggered processes and reflections on one’s own health and situation. However, mindful walking and moderate walking seem to address different resources. This important knowledge may help oncologists and other therapists to assess what type of interventions can best meet the needs and requirements of individual patients. Trial registration: DKRS00011521; prospectively registered 21.12.2016; https://drks.de/search/de/trial/DRKS00011521