bluuebunny/crossref_metadata_2025_split huggingface dataset:
Compliant variable admittance adaptive fixed-time sliding mode control for trajectory tracking of robotic manipulators
Authors: Gao Hang , Ma Chao , Zhang Xiaodong , Zhou Cheng 
Published: May 2024

AbstractThis paper presents a compliant variable admittance adaptive fixed-time sliding mode control (SMC) algorithm for trajectory tracking of robotic manipulators. Specifically, a compliant variable admittance algorithm and an adaptive fixed-time SMC algorithm are combined to construct a double-loop control structure. In the outer loop, the variable admittance algorithm is developed to adjust admittance parameters during a collision to minimize the collision time, which gives the robot compliance property and reduce the rigid collision influence. Then, by employing the Lyapunov theory and the fixed-time stability theory, a new nonsingular sliding mode manifold is proposed and an adaptive fixed-time SMC algorithm is presented in the inner loop. More precisely, this approach enables rapid convergence, enhanced steady-state tracking precision, and a settling time that is independent of system initial states. As a result, the effectiveness and improved performance of the proposed algorithm are demonstrated through extensive simulations and experimental results.
Threshold dynamics scenario of a plants-pollinators cooperative system with impulsive effect on a periodically evolving domain
Authors: Wang Jie , Yang Ruirui , Wang Jian , Cao Jianxiong 
Published: May 2024

AbstractFlowering plants depend on some animals for pollination and contribute to nourish the animals in natural environments. We call these animals pollinators and build a plants-pollinators cooperative model with impulsive effect on a periodically evolving domain. Next, we define the ecological reproduction index for single plant model and plants-pollinators system, respectively, whose threshold dynamics, including the extinction, persistence and coexistence, is established by the method of upper and lower solutions. Theoretical analysis shows that a large domain evolution rate has a positive influence on the survival of pollinators whether or not the impulsive effect occurs, and the pulse eliminates the pollinators even when the evolution rate is high. Moreover, some selective numerical simulations are still performed to explain our theoretical results.
Demographics and FDI: lessons from China’s one-child policy
Authors: Donaldson John B. , Koulovatianos Christos , Li Jian , Mehra Rajnish 
Published: May 2024

Abstract
Following the introduction of the one-child policy in China, the capital-labor ratio of China increased relative to that of India, while FDI/GDP inflows to China versus India simultaneously declined. These observations are explained in the context of a simple neoclassical overlapping generations paradigm. The adjustment mechanism works as follows: the reduction in the growth rate of the (urban) labor force due to the one-child policy increases the capital per worker inherited from the previous generation. The resulting increase in China’s domestic capital-labor ratio thus "crowds out" the need for foreign direct investment (FDI) in China relative to India. Our paper is a contribution to the nascent literature exploring demographic transitions and their effects on FDI flows.
Raindrop Deformation in Turbulence
Authors: Zheng Hepeng , Zhang Yun , Li Haoran , Wu Zuhang , Xie Yanqiong , Zhang Lifeng 
Published: May 2024

AbstractThe physical behavior of a falling raindrop is governed by delicate fluid dynamics and thermodynamics, and oscillates with time. Despite this time‐variant nature, past observational and simulation studies have aimed to generalize parameterizations for describing rain microphysics bearing the assumption that raindrops fall at terminal speeds with an equilibrium shape. However, the applicability of this hypothesis in a realistic atmosphere that is inherently turbulent remains an open question. Here, we employ novel retrieval techniques to quantify the impact of turbulence on raindrop microphysics using long‐term in situ observations with careful assessment of the wind effect. We find that raindrop microphysics increasingly deviate from the equilibrium state as the turbulence dissipation rate increases, and this effect is more pronounced for large raindrops. We present turbulence‐invoked rain microphysical parameterizations which shed light on the complex interactions between turbulence dynamics and raindrop microphysics.
Atlantic Meridional Overturning Circulation Influence on the Annual Mean Intertropical Convergence Zone Location in the Miocene
Authors: Liu Xiaoqing , Herold Nicholas , Huber Matthew 
Published: May 2024

AbstractThe Intertropical Convergence Zone (ITCZ) has an annual mean location north of the equator today. The factors determining this location and the evolution to its modern state are actively debated. Here we investigate how the Atlantic Meridional Overturning Circulation (AMOC) influences the ITCZ during the early‐to‐middle Miocene. By conducting a sensitivity study with an open Canadian Arctic Archipelago gateway, we show that North Atlantic Deep‐Water formation strengthens the AMOC, in alignment with Miocene North Atlantic ventilation proxies. A vigorous AMOC increases northward Atlantic Ocean heat transport and cross‐equatorial atmospheric energy transport shifts southwards to compensate, pushing the ITCZ northwards. Our study supports AMOC development as a strong contributor to the ITCZ's northern location today. Existing proxy‐based interpretations of ITCZ history are too sparse to strongly confirm these results. We predict a strong in‐phase relationship between AMOC strength and ITCZ's northward location, which should be testable in high resolution paleoclimate records.
Velocity Measurements of Powdered Rock at Low Confining Pressures and Comparison to Lunar Shallow Seismic Velocity
Authors: Amos C. C. , Prasad M. , Cannon K. M. , Dreyer C. B. 
Published: May 2024

AbstractSeismic methods will be useful for future lunar near‐surface characterization, and high‐fidelity elastic models will be required to aid interpretation of seismic observations. To develop an elastic lunar near‐surface model, we performed ultrasonic velocity measurements of lunar regolith simulant at low confining pressure and developed a rock physics model calibrated to these measurements. Grain contact models based on Hertz‐Mindlin theory produce accurate results at high confining pressure (i.e., several hundred meters or more burial depth) but historically fail to predict observed velocities in unconsolidated media at low pressure. Therefore, we heuristically modified existing models to fit our measured data over a range of porosities and confining pressures. To compare with Apollo 14 and 16 active seismic experiments, we used our new heuristic rock physics model to produce lunar subsurface velocity profiles. We performed ray tracing through our velocity profiles to calculate seismic traveltime, which results in good agreement with first arrivals interpreted from the Apollo experiments. Our model suggests a slightly higher velocity‐pressure dependence than inferred from in situ measurements, which may be due to porosity reduction in the lunar regolith from impact‐induced and natural vibrations.
Patient-derived follicular lymphoma spheroids recapitulate lymph node signaling and immune profile uncovering galectin-9 as a novel immunotherapeutic target
Authors: Dobaño-López Cèlia , Valero Juan García , Araujo-Ayala Ferran , Nadeu Ferran , Gava Fabien , Faria Carla , Norlund Marine , Morin Renaud , Bernes-Lasserre Pascale , Arenas Fabian , Grau Marta , López Cristina , López-Oreja Irene , Serrat Neus , Martínez-Farran Ares , Hernández Lluís , Playa-Albinyana Heribert , Giménez Rubén , Beà Silvia , Campo Elías , Lagarde Jean-Michel , López-Guillermo Armando , Magnano Laura , Colomer Dolors , Bezombes Christine , Pérez-Galán Patricia 
Published: May 2024

Abstract
Follicular lymphoma (FL), the most common indolent non-Hodgkin lymphoma, constitutes a paradigm of immune tumor microenvironment (TME) contribution to disease onset, progression, and heterogenous clinical outcome. Here we present the first FL-Patient Derived Lymphoma Spheroid (FL-PDLS), including fundamental immune actors and features of TME in FL lymph nodes (LNs). FL-PDLS is organized in disc-shaped 3D structures composed of proliferating B and T cells, together with macrophages with an intermediate M1/M2 phenotype. FL-PDLS recapitulates the most relevant B-cell transcriptional pathways present in FL-LN (proliferation, epigenetic regulation, mTOR, adaptive immune system, among others). The T cell compartment in the FL-PDLS preserves CD4 subsets (follicular helper, regulatory, and follicular regulatory), also encompassing the spectrum of activation/exhaustion phenotypes in CD4 and CD8 populations. Moreover, this system is suitable for chemo and immunotherapy testing, recapitulating results obtained in the clinic. FL-PDLS allowed uncovering that soluble galectin-9 limits rituximab, rituximab, plus nivolumab/TIM-3 antitumoral activities. Blocking galectin-9 improves rituximab efficacy, highlighting galectin-9 as a novel immunotherapeutic target in FL. In conclusion, FL-PDLS maintains the crosstalk between malignant B cells and the immune LN-TME and constitutes a robust and multiplexed pre-clinical tool to perform drug screening in a patient-derived system, advancing toward personalized therapeutic approaches.
A novel inhibitor of the mitochondrial respiratory complex I with uncoupling properties exerts potent antitumor activity
Authors: Al Assi Alaa , Posty Solène , Lamarche Frédéric , Chebel Amel , Guitton Jérôme , Cottet-Rousselle Cécile , Prudent Renaud , Lafanechère Laurence , Giraud Stéphane , Dallemagne Patrick , Suzanne Peggy , Verney Aurélie , Genestier Laurent , Castets Marie , Fontaine Eric , Billaud Marc , Cordier-Bussat Martine 
Published: May 2024

AbstractCancer cells are highly dependent on bioenergetic processes to support their growth and survival. Disruption of metabolic pathways, particularly by targeting the mitochondrial electron transport chain complexes (ETC-I to V) has become an attractive therapeutic strategy. As a result, the search for clinically effective new respiratory chain inhibitors with minimized adverse effects is a major goal. Here, we characterize a new OXPHOS inhibitor compound called MS-L6, which behaves as an inhibitor of ETC-I, combining inhibition of NADH oxidation and uncoupling effect. MS-L6 is effective on both intact and sub-mitochondrial particles, indicating that its efficacy does not depend on its accumulation within the mitochondria. MS-L6 reduces ATP synthesis and induces a metabolic shift with increased glucose consumption and lactate production in cancer cell lines. MS-L6 either dose-dependently inhibits cell proliferation or induces cell death in a variety of cancer cell lines, including B-cell and T-cell lymphomas as well as pediatric sarcoma. Ectopic expression of Saccharomyces cerevisiae NADH dehydrogenase (NDI-1) partially restores the viability of B-lymphoma cells treated with MS-L6, demonstrating that the inhibition of NADH oxidation is functionally linked to its cytotoxic effect. Furthermore, MS-L6 administration induces robust inhibition of lymphoma tumor growth in two murine xenograft models without toxicity. Thus, our data present MS-L6 as an inhibitor of OXPHOS, with a dual mechanism of action on the respiratory chain and with potent antitumor properties in preclinical models, positioning it as the pioneering member of a promising drug class to be evaluated for cancer therapy.
Anomalous dynamics of a passive droplet in active turbulence
Authors: Singh Chamkor , Chaudhuri Abhishek 
Published: May 2024

AbstractMotion of a passive deformable object in an active environment serves as a representative of both in-vivo systems such as intracellular particle motion in Acanthamoeba castellanii, or in-vitro systems such as suspension of beads inside dense swarms of Escherichia coli. Theoretical modeling of such systems is challenging due to the requirement of well resolved hydrodynamics which can explore the spatiotemporal correlations around the suspended passive object in the active fluid. We address this critical lack of understanding using coupled hydrodynamic equations for nematic liquid crystals with finite active stress to model the active bath, and a suspended nematic droplet with zero activity. The droplet undergoes deformation fluctuations and its movement shows periods of “runs” and “stays”. At relatively low interfacial tension, the droplet begins to break and mix with the outer active bath. We establish that the motion of the droplet is influenced by the interplay of spatial correlations of the flow and the size of the droplet. The mean square displacement shows a transition from ballistic to normal diffusion which depends on the droplet size. We discuss this transition in relation to spatiotemporal scales associated with velocity correlations of the active bath and the droplet.
Multi-site integrated optical addressing of trapped ions
Authors: Kwon Joonhyuk , Setzer William J. , Gehl Michael , Karl Nicholas , Van Der Wall Jay , Law Ryan , Blain Matthew G. , Stick Daniel , McGuinness Hayden J. 
Published: May 2024

AbstractOne of the most effective ways to advance the performance of quantum computers and quantum sensors is to increase the number of qubits or quantum resources in the system. A major technical challenge that must be solved to realize this goal for trapped-ion systems is scaling the delivery of optical signals to many individual ions. In this paper we demonstrate an approach employing waveguides and multi-mode interferometer splitters to optically address multiple 171Yb+ ions in a surface trap by delivering all wavelengths required for full qubit control. Measurements of hyperfine spectra and Rabi flopping were performed on the E2 clock transition, using integrated waveguides for delivering the light needed for Doppler cooling, state preparation, coherent operations, and detection. We describe the use of splitters to address multiple ions using a single optical input per wavelength and use them to demonstrate simultaneous Rabi flopping on two different transitions occurring at distinct trap sites. This work represents an important step towards the realization of scalable integrated photonics for atomic clocks and trapped-ion quantum information systems.
Delayed room temperature phosphorescence enabled by phosphines
Authors: Lu Guang , Tan Jing , Wang Hongxiang , Man Yi , Chen Shuo , Zhang Jing , Duan Chunbo , Han Chunmiao , Xu Hui 
Published: May 2024

AbstractOrganic ultralong room-temperature phosphorescence (RTP) usually emerges instantly and immediately decays after excitation removal. Here we report a new delayed RTP that is postponed by dozens of milliseconds after excitation removal and decays in two steps including an initial increase in intensity followed by subsequent decrease in intensity. The delayed RTP is achieved through introduction of phosphines into carbazole emitters. In contrast to the rapid energy transfer from single-molecular triplet states (T1) to stabilized triplet states (Tn*) of instant RTP systems, phosphine groups insert their intermediate states (TM) between carbazole-originated T1 and Tn* of carbazole-phosphine hybrids. In addition to markedly increasing emission lifetimes by ten folds, since TM → Tn* transition require >30 milliseconds, RTP is thereby postponed by dozens of milliseconds. The emission character of carbazole-phosphine hybrids can be used to reveal information through combining instant and delayed RTP, realizing multi-level time resolution for advanced information, biological and optoelectronic applications.
Timing the evolution of phosphorus-cycling enzymes through geological time using phylogenomics
Authors: Boden Joanne S. , Zhong Juntao , Anderson Rika E. , Stüeken Eva E. 
Published: May 2024

AbstractPhosphorus plays a crucial role in controlling biological productivity, but geological estimates of phosphate concentrations in the Precambrian ocean, during life’s origin and early evolution, vary over several orders of magnitude. While reduced phosphorus species may have served as alternative substrates to phosphate, their bioavailability on the early Earth remains unknown. Here, we reconstruct the phylogenomic record of life on Earth and find that phosphate transporting genes (pnas) evolved in the Paleoarchean (ca. 3.6-3.2 Ga) and are consistent with phosphate concentrations above modern levels ( > 3 µM). The first gene optimized for low phosphate levels (pstS; <1 µM) appeared around the same time or in the Mesoarchean depending on the reconstruction method. Most enzymatic pathways for metabolising reduced phosphorus emerged and expanded across the tree of life later. This includes phosphonate-catabolising CP-lyases, phosphite-oxidising pathways and hypophosphite-oxidising pathways. CP-lyases are particularly abundant in dissolved phosphate concentrations below 0.1 µM. Our results thus indicate at least local regions of declining phosphate levels through the Archean, possibly linked to phosphate-scavenging Fe(III), which may have limited productivity. However, reduced phosphorus species did not become widely used until after the Paleoproterozoic Great Oxidation Event (2.3 Ga), possibly linked to expansion of the biosphere at that time.
The complete assembly of human LAT1-4F2hc complex provides insights into its regulation, function and localisation
Authors: Wu Di , Yan Renhong , Song Siyuan , Swansiger Andrew K. , Li Yaning , Prell James S. , Zhou Qiang , Robinson Carol V. 
Published: May 2024

AbstractThe LAT1-4F2hc complex (SLC7A5-SLC3A2) facilitates uptake of essential amino acids, hormones and drugs. Its dysfunction is associated with many cancers and immune/neurological disorders. Here, we apply native mass spectrometry (MS)-based approaches to provide evidence of super-dimer formation (LAT1-4F2hc)2. When combined with lipidomics, and site-directed mutagenesis, we discover four endogenous phosphatidylethanolamine (PE) molecules at the interface and C-terminus of both LAT1 subunits. We find that interfacial PE binding is regulated by 4F2hc-R183 and is critical for regulation of palmitoylation on neighbouring LAT1-C187. Combining native MS with mass photometry (MP), we reveal that super-dimerization is sensitive to pH, and modulated by complex N-glycans on the 4F2hc subunit. We further validate the dynamic assemblies of LAT1-4F2hc on plasma membrane and in the lysosome. Together our results link PTM and lipid binding with regulation and localisation of the LAT1-4F2hc super-dimer.
Transition role of entangled data in quantum machine learning
Authors: Wang Xinbiao , Du Yuxuan , Tu Zhuozhuo , Luo Yong , Yuan Xiao , Tao Dacheng 
Published: May 2024

AbstractEntanglement serves as the resource to empower quantum computing. Recent progress has highlighted its positive impact on learning quantum dynamics, wherein the integration of entanglement into quantum operations or measurements of quantum machine learning (QML) models leads to substantial reductions in training data size, surpassing a specified prediction error threshold. However, an analytical understanding of how the entanglement degree in data affects model performance remains elusive. In this study, we address this knowledge gap by establishing a quantum no-free-lunch (NFL) theorem for learning quantum dynamics using entangled data. Contrary to previous findings, we prove that the impact of entangled data on prediction error exhibits a dual effect, depending on the number of permitted measurements. With a sufficient number of measurements, increasing the entanglement of training data consistently reduces the prediction error or decreases the required size of the training data to achieve the same prediction error. Conversely, when few measurements are allowed, employing highly entangled data could lead to an increased prediction error. The achieved results provide critical guidance for designing advanced QML protocols, especially for those tailored for execution on early-stage quantum computers with limited access to quantum resources.
High-resolution impact-based early warning system for riverine flooding
Authors: Najafi Husain , Shrestha Pallav Kumar , Rakovec Oldrich , Apel Heiko , Vorogushyn Sergiy , Kumar Rohini , Thober Stephan , Merz Bruno , Samaniego Luis 
Published: May 2024

AbstractDespite considerable advances in flood forecasting during recent decades, state-of-the-art, operational flood early warning systems (FEWS) need to be equipped with near-real-time inundation and impact forecasts and their associated uncertainties. High-resolution, impact-based flood forecasts provide insightful information for better-informed decisions and tailored emergency actions. Valuable information can now be provided to local authorities for risk-based decision-making by utilising high-resolution lead-time maps and potential impacts to buildings and infrastructures. Here, we demonstrate a comprehensive floodplain inundation hindcast of the 2021 European Summer Flood illustrating these possibilities for better disaster preparedness, offering a 17-hour lead time for informed and advisable actions.
Dinuclear gold-catalyzed divergent dechlorinative radical borylation of gem-dichloroalkanes
Authors: Ji Cheng-Long , Chen Hongliang , Gao Qi , Han Jie , Li Weipeng , Xie Jin 
Published: May 2024

AbstractThe enormous and widespread use of organoboronic acids has prompted the development of innovative synthetic methodologies to meet the demands on structural diversity and functional group tolerance. The existing photoinduced defunctionalization radical borylation, typically focused on the conversion of one C-X bond (X= Br, I, or other leaving group) into only one C-B bond. Herein, we disclose a divergent radical dechloroborylation reaction enabled by dinuclear gold catalysis with visible light irradiation. A wide range of structurally diverse alkyl boronic, α-chloroboronic, and gem-diboronic esters can be synthesized in moderate to good yields (up to 92%). Its synthetic robustness is further demonstrated on a preparative scale and applied to late-stage diversification of complex molecules. The process hinges on a C-Cl bond relay activation in readily available gem-dichloroalkanes through inner-sphere electron transfer, overcoming the redox potential limits of unreactive alkyl chlorides.