bluuebunny/crossref_metadata_2025_split huggingface dataset:
Anxiety-depressive disorders in patients with coronary artery disease with borderline coronary artery stenosis and visceral obesity
Authors: Yakhontov D. A. , Ostanina Yu. O. , Dunicheva O. V. , Tsibina T. G. , Kokoulina N. A. , Lukinov V. L. 
Published: May 2024

Aim. To assess the prevalence of anxiety-depressive disorders in pa­tients with coronary artery disease (CAD) with borderline coronary artery (CA) stenosis and visceral obesity.Material and methods. The study involved 201 patients with stable CAD with class I-III angina pectoris with borderline (50-70%) coronary stenosis. The first group consisted of patients with stable borderline CAD with increased epicardial fat thickness (EFT) — 57 (28,4%) people, the second group — patients without increased EFT — 144 (71,6%) people. Blood biochemical tests, levels of inflammatory markers (high-sensitivity C-reactive protein, interleukin (IL)-1, IL-6, IL-8, IL-10, tumor necrosis factor alpha, N-terminal pro-brain natriuretic peptide) were assessed. Cardiac ultrasound was used to determine EFT. All patients underwent coronary angiography. Levels of anxiety and depression were assessed using the Hospital Anxiety and Depression Scale (HADS).Results. The average EFT in group 1 was 6,00 [5,00; 6,50] mm, in group 2 — 3,00 [2,30; 4,00] mm (p<0,001). In group 1 patients, hypertension (p<0,001), coronary artery disease (p<0,001) in general and myocardial infarction (p=0,003) in particular debuted at a younger age. The groups did not differ significantly in the incidence of obesity, type 2 diabetes, functional class of angina, or the intake rate of all 4 main drug groups. Patients with increased EFT were more likely to have elevated levels of N-terminal pro-brain natriuretic peptide (p=0,002), high-sensitivity C-reactive protein (p=0,027), as well as higher values (p=0,005) and a higher frequency of increasing (p<0,001) the antiinflammatory cytokine IL-10. When analyzing the anxiety-depressive profile, the sum of depression scores and the incidence of subclinical depression were significantly (p<0,001) higher in the group of patients with increased EFT.Conclusion. Patients with stable CAD with borderline coronary artery stenosis and increased EFT, which is a marker of visceral obesity, are characterized by an earlier age of manifestation of hypertension and coronary artery disease, the presence of a pro-inflammatory phenotype and a higher level of subclinical depression.
Sixteen-year incidence changes of four main disease classes in the North Caucasus
Authors: Mamedov M. N. , Mammaev S. N. , Umetov M. A. , Toguzova Z. A. , Didigova R. T. , Kechedzhieva S. G. 
Published: May 2024

Aim. To assess the changes of four main disease classes in the North Caucasus Federal District from 2005 to 2021.Material and methods. The incidence changes of cardiovascular diseases (CVDs), neoplasms, respiratory and endocrine diseases, as well as nutritional and metabolic disorders are analyzed. The disease incidence was assessed as registration of newly diagnosed diseases per 1 thousand people according to official data from Rosstat published in 2022.Results. In the North Caucasus region over the past 16 years, an increase in incidence rates has been observed for the main disease classes. The first place is occupied by CVDs, the number of which increased in 2021 compared to 2005 by 80%. The incidence of respiratory increased by 40%, while cancer by 20%. At the same time, the incidence of endocrine diseases, as well as nutritional and metabolic disorders decreased by 18%. In general, similar morbidity dynamics are observed for the first three disease groups. At the same time, in 2021, only for CVDs, the average incidence rates in the Russian Federation and the North Caucasian Federal District turned out to be comparable, and for cancer, respiratory, metabolic disorders and endocrine diseases in the North Caucasus Federal District, the incidence rates were lower compared to the Russian Federation as a whole. In some regions, both general trends and variability in the incidence of individual noncommunicable diseases are observed.Conclusion. The data obtained indicate that over a 16-year period, the incidence of CVDs, respiratory and cancer diseases has increased in the North Caucasus Federal District. This once again emphasizes the need for effective medical examination of the adult population and the implementation of primary prevention at the population level and among high-risk individuals.
Regional variability of male and female mortality from three types of coronary artery disease: comparison of two periods 2017-2019 and 2020-2022
Authors: Samorodskaya I. V. , Klyuchnikov I. V. , Shepel R. N. , Kakorina E. P. , Drapkina O. M. 
Published: May 2024

Aim. To assess regional variability of standardized mortality rates (SMRs) for men and women from three types of coronary artery disease (CAD) for 2 periods (2017-2019 and 2020-2022).Material and methods. Rosstat data on the average annual population and the number of deaths in one-year age groups for 82 constituent Russian entities were used. SMRs was calculated using software (state registration number 216661114) and the European Standard Population by the direct standardization per 100 thousand population. The average regional SMRs were calculated for 2017-2019 and 2020­2022 as follows: (I21-I22) myocardial infarction (MI); (I20, I24.1-9) other acute coronary artery disease types; (I25.0-9) chronic coronary syndromes; all 3 groups of CAD.Results. We found that the regional average CAD SMR among men (343,0±98,3 and 364,2±105,7 per 100 thousand population) is >2 times than among women (163,3±55,7 and 179, 5±61,2 per 100 thousand population), but men and women did not differ in the average regional proportion of CAD in the structure of all-cause mortality. In 5 regions, a simultaneous decrease in SMR from three CAD types and their total indicator was registered in both men and women; in 8, an increase in SMR was registered for each of the three forms and their sum, and in the remaining regions, multidirectional dynamics were noted. The coefficient of variation of regional MI SMR changes for men was 830%, for women — 322%; for other acute CAD — 7145% and 2523%, respectively. In general, the increase in CAD SMR occurred mainly due to an increase in SMR from chronic CAD against the background of a decrease in MI SMR. The proportion of chronic CAD in the structure of all CAD types is higher in women (80,1±11,9 and 82,9±10,3%) than in men (75,5±14 and 77,6±13%). The proportion of MI among men is 14,8±6,1 and 13,5±6,6%, among women — 7,1±10,9 and 6,2±8,7%.Conclusion. The pronounced variability of regional SMRs and their changes over time, differences in mortality structure between men and women indicate a number of unresolved statistical issues related to determining the initial cause of death from CAD and its individual types, including with multimorbid pathology.
Clinical case of primary transcorporal artificial urinary sphincter cuff implantation
Authors: Tomilov A. A. , Veliev E. I. , Golubtsova E. N. 
Published: May 2024

Among surgical methods of treatment of male stress urinary incontinence, implantation of an artificial urinary sphincter is the leading technique. Despite its acceptable effectiveness, the intervention carries a risk of complications, some of which require removal of a component or the entire device.The article presents a clinical case of primary artificial urinary sphincter cuff placement and literature review on this topic.
Nephrometry scoring systems RENAL, PADUA, C-index, SPARE, and ZONAL NePhRO for prediction of partial nephrectomy outcomes
Authors: Guliev B. G. , Povago I. A. 
Published: May 2024

Background. Modern imaging methods make it possible to detect kidney tumors at early stages which, along with active development of laparoscopic technologies, has led to an increase in the number of nephron-sparing surgeries and their effectiveness. The RENAL, PADUA, C-index, ZONAL NePhRO, and SPARE nephrometry score systems are actively used to predict outcomes of partial nephrectomy.Aim. To evaluate the effectiveness of nephrometry scores in predicting the results of minimally invasive partial nephrectomy.Materials and methods. The data on 90 patients who underwent laparoscopic or robotic partial nephrectomy at the Urology Center of the Mariinsky Hospital from September 2021 to May 2023 were retrospectively evaluated. There were 43 men (47.8 %) and 47 women (52.2 %). The median age of patients was 61 years (interquartile range (IQR) 48–69). Tumor of the left kidney was diagnosed in 46 (51.1 %) patients, and tumor of the right kidney in 44 (48.9 %) patients.Results. Mean operative time was 132 ± 39 minutes. Median warm ischemia time and intraoperative blood loss were 15 minutes (IQR 12–20 min) and 150 mL (IQR 70–257.5), respectively. Mean hemoglobin level and red blood cell count before surgery were 132 ± 15 g/L and 4.6 ± 0.63 × 1012/L, respectively. After the surgery, the mean values were 119 ± 16 g/L and 4.06 ± 0.6 × 1012/L, respectively. Median creatinine and mean glomerular filtration rate before surgery were 83.5 µmol/L (IQR 72–97 µmol/L) and 76.9 ± 21 mL/min, respectively; in the early postoperative period, 83 µmol/L (IQR 70–100 µmol/L) and 76.4 ± 24 mL/min, respectively. The strongest relationship was established between the RENAL and PADUA scores (r = 0.907; p <0.001), a slightly weaker relationship was found for the PADUA and SPARE scores, as well as PADUA and C-index (r = 0.856; p <0.001 and r = –0.785; p <0.001, respectively). The RENAL score showed high predictive value in assessing the volume of intraoperative blood loss and operative time (r = 0.881; p = 0.001 and r = 0.854; p <0.001, respectively). The PADUA scale demonstrated high predictive efficiency for warm ischemia time (r = 0.775; p = 0.001). C-index significantly predicted the volume of intraoperative blood loss and operative time (r = –0.807; p <0.001 and r = –0.797; p = 0.001, respectively).Conclusion. All of the above nephrometry scores showed high predictive efficiency, but the RENAL and PADUA scores were the most valuable.
Long-term outcomes of hypofractionated radiation therapy in patients with high risk prostate cancer
Authors: Bulychkin P. V. , Ekaterinushkin D. A. , Tkachev S. I. , Khachaturyan A. V. , Nayanov G. B. , Ladyko D. D. , Selezneva T. D. 
Published: May 2024

Background. Hypofractionated radiation therapy is a standard radical approach for treatment of patients with localized prostate cancer of low and intermediate risk. Clinical practice of applying this approach in patients with high and very high risk of progression has not been established.Aim: improving the effectiveness of hormonal/radiation therapy in patients with high and very high risk prostate cancer using an original radiotherapy technique.Materials and methods. In 2012, a new technique of hypofractionated radiation therapy based on simultaneous integrated boost aimed at the prostate, seminal vesicles, and regional lymph nodes was developed at the Radiotherapy Department of the N.N. Blokhin National Medical Research Center of Oncology. The phase II single-center prospective cohort trial included 40 patients with high and very high risk prostate cancer who received combination hormonal/ radiation therapy between 2012 and 2018. Median follow-up was 96 (61–124) months.Results. None of the patients had grade III–IV adverse events (according to the RTOG/EORTC scale) in the distal parts of the gastrointestinal tract and urogenital system. Five-year biochemical and local controls were 80 % and 100 %, respectively.Conclusion. The results of this study show that the developed hypofractionated radiation therapy technique is safe with 5-year biochemical control outcomes matching reported in the literature. However, to determine true clinical significance of the technique, initiation of a randomized phase III trial is required.
Methodological aspects of implantation of a Russian prostate-rectum spacer based on stabilized hyaluronic acid of non-animal origin
Authors: Novikov R. V. , Zhivulina T. V. , Sysoeva V. V. , Protoshchak V. V. , Karandashov V. K. , Gozalishvili S. M. , Novikov S. N. 
Published: May 2024

Over the past few years, the use of spacers to optimize radiation treatment of prostate cancer has become increasingly popular in radiotherapy practice. In Russia, the experience of clinical application of this technology is small and limited to few trials at federal centers. The technique of perineal implantation of a biodegradable spacer is invasive and requires the participation of specialists with appropriate manual skills. Therefore, informing urologists, urologic oncologists, and interventional radiologists on the methodological aspects of this procedure has significant practical importance.The purpose of this work is to describe the methodology of using a new Russian medical device as a biodegradable spacer – a monophasic implantable gel (hydrogel) based on stabilized (cross-linked) hyaluronic acid of non-animal origin (EsteFILL intim), which makes it possible to reduce radiation exposure to the anterior wall of the rectum and has other positive effects (increased accuracy of radiation delivery, reduced risks of radiation-induced erectile dysfunction) in different radiotherapy methods of prostate cancer treatment. The described procedure was developed and approved at the Department of Radiotherapy of the N.N. Petrov National Medical Research Center of Oncology. The design of the study implying implantation of the stabilized non-animal hyaluronic acid (EsteFILL intim) was approved by the local ethics committee (protocol No. 16 dated 21.09.2023) and approved as a promising research work at the meetings of the Problem Commission (protocol No. 125 dated 25.09.2023) and the Academic Council of the N.N. Petrov National Medical Research Center of Oncology (protocol No. 8 dated 26.09.2023).
Expanding the spectrum of clinical and genetic characteristics of distal arthrogryposis type 5 caused by heterozygous variants in the PIEZO2 gene
Authors: Dadali E. L. , Markova T. V. , Melnik E. A. , Nikitin S. S. , Sharkova I. V. , Khalanskaya O. V. , Bessonov L. A. , Shestopalova E. A. , Ryzhkova O. P. , Trofimova S. I. , Agranovich O. E. , Kutsev S. I. 
Published: May 2024

Pathogenic heterozygous variants in the PIEZO2 gene cause distal arthrogryposis type 5 – a rare autosomal dominant disease, which is characterized by the development of congenital contractures, ophthalmoparesis, ptosis and restrictive respiratory disorders. We have presented clinical and genetic characteristics of seven Russian patients with distal arthrogryposis type 5 caused by previously described and newly identified nucleotide variants in the PIEZO2 gene. It was shown that the most severe clinical manifestations were found in patients with newly identified nucleotide variants c.8238G>A (p.Trp274Ter) and c.7095G>T (p.Trp2365Cys), while in patients with other previously described variants c.8181_8183delAGA (p.Glu2727del) and c.2134A>G (p.Met712Val) the clinical phenotype is more moderately expressed. The dynamics of phenotype formation were also noted. It has been shown that the disease progression may occur as the child grows and requires monitoring of this group of patients.
Delayed motor, mental and speech development and congenital brain malformations: the first description of Zhu–Tokita–Takenouchi–Kim syndrome in Russia
Authors: Kondakova O. B. , Gudkova A. P. , Demyanov S. V. , Davydova Yu. I. , Lyalina A. A. , Grebenkin D. I. , Bakovich E. A. , Kanivets I. V. , Demyanov D. S. , Zhanin I. S. , Pushkov A. A. , Savostyanov K. V. 
Published: May 2024

Zhu–Tokita–Takenouchi–Kim syndrome (ZTTK syndrome) is a rare autosomal dominant nuclear speckleopathy characterized by developmental delay, hypotonia, intellectual disability, facial dysmorphism in association with variable brain malformations, musculoskeletal abnormalities and ocular involvement. Currently, 87 cases of ZTTK syndrome have been described worldwide. The syndrome caused by mutations in the SON gene, located on the long arm of chromosome 21 (21q22.11). Nonsense and frameshift mutations have been described in the SON gene. Missense mutations, partial or whole gene deletions are less common.The aim of the work is to analyze the clinical picture and molecular genetic results of patients with confirmed ZTTK syndrome and compare them with data from foreign literature.We observed the one boy and two girls with ZTTK syndrome aged 13 months to 59 months, averaging about 38 months. DNA diagnostic was performed by next generation sequencing. All patients and all parents were confirmed by Sanger sequening. Three pathogenic variants were identified: c.5753_5756delTTAG (p.Val1918Glufs*87), c.1531del (p.Thr511Glnfs*9) and c.403delG (p.Glu135Asnfs*14). The first one was is most common, the other two are novel variants. Most patients had growth, motor and speech delay, seizures, hypotonia, congenital heart defects, urinary tract abnormalities and brain malformations. Comparative analysis of facial features in patients with ZTTK syndrome showed downslanting palpebral fissures, epicantal folds, broad or depressed nasal bridge, flared nares, smooth philtrum, thin upper lip and low set, rotated ears. The use of next generation sequencing as a first‑line test for research and diagnostic of ZTTK syndrome is advisable due to the pronounced clinical polymorphism.
The effectiveness of the use of microfertilizers on the yield and biochemical composition of watermelon of different ripeness groups
Authors: Galichkina E. A. , Nadezhkin S. M. 
Published: May 2024

Relevance. The priority direction in vegetable growing is the scientifically justified use of types and doses of micronutrients that can increase the yield of watermelon fruits and improve their quality. Due to the large number of different types of fertilizers currently appearing on the market, it is necessary to choose the right ones and study them in optimal doses for growing high-quality melon products.Material and methodology. Objects of research: watermelon varieties Meteor, Zemlyanin, Kholodok and preparations: iron chelate, zinc chelate, vegetable Aquarin. Options using these fertilizers for double foliar treatment of plants during the growing season have been studied. The research was carried out during 2019-2021 at the Bykovskaya melon breeding experimental station.Results. During the study, a positive effect of the tested drugs on the quantitative and qualitative indicators of products was established. As a result of foliar treatments of plants in all variants, the yield exceeded the control variant (without treatments). A comparative analysis of biochemical data showed that the dry matter content was at a fairly high level. As a result of the use of zinc chelate in the Meteor and Kholodok cv., the dry matter content increased by 0.4%. A similar increase in the indicator was obtained when using the drug Aquarin vegetable on the Zemlyanin and Kholodok cv. The content of total sugar in the Meteor and Kholodok cv. was higher than the control (without treatments), and in the Zemlyanin cv. it was at the control level. The fructose content in the tested variants of all varieties exceeded the control. As a result of the use of water-soluble fertilizers for plant treatment, the content of ascorbic acid increased in the variants with treatment in the Meteor cv. – by 1-1.5 mg%, in the Zemlyanin cv. – by 0.8-1.1 mg%, in the Kholodok cv. – by 0 .1-0.7 mg% compared to control (without treatments). Nitrate levels in watermelon fruits of different ripening periods did not exceed the maximum permissible concentration (60 mg/kg).
Bioclimatic coefficients of seedlings of fruit and berry crops under drip irrigation in the conditions of the Central Non-Black Earth Region
Authors: Dubenok N. N. , Gemonov A. V. , Lebedev A. V. 
Published: May 2024

Relevanse. An important condition for the effectiveness of gardening is the systematic replacement of old plantings with new ones. The supply of planting material to the industry is important. Imported planting material does not always meet quality requirements and is not always adapted to the soil and climatic conditions of the region in which fruit and berry plantings are planted. Despite the spread of low-volume irrigation, for the regions of the Central Non-Black Earth Region (Central NonChernozem region) of Russia, only a few studies have been carried out to study drip irrigation regimes for fruit and berry nurseries, therefore, issues related to the development of rational irrigation regimes are of particular relevance.Methods. Field research was carried out on the territory of the educational and experimental farm of the Michurinsky Garden fruit growing laboratory of the Russian State Agrarian University Moscow Timiryazev Agricultural Academy from 2011 to 2022. Field experiments on growing one-year-old, twoyear-old and three-year-old seedlings were carried out in triplicate according to the following options: 1) control (without irrigation), 2) maintaining the moisture content of the root layer in the range of 60-80 %, 3) 70-90% and 4) 80-100% of the lowest moisture capacity. The obtained experimental data were processed using regression analysis methods.Results. The resulting mathematical and statistical models make it possible to calculate the bioclimatic coefficients of plum, cherry, raspberry, pear and apple seedlings depending on pre-irrigation soil moisture and the sum of average daily temperatures for the conditions of the Central NonChernozem Zone of Russia. All the fruit and berry crops under consideration are characterized by a general pattern that, depending on the sum of average daily temperatures, bioclimatic coefficients change according to a parabolic dependence, and have minimum values at the beginning of the growing season, reach maximum values during the period of intensive growth of seedlings and gradually decrease towards the end of the growing season.
Contextualizing Inequities in COVID Vaccination Trends Among Project REFOCUS Pilot Sites: Racism-Related Determinants of Health
Authors: Nwankwo Ezinne , Le Cindy , Bradford Natalie J. , Trujillo Dillon , Fletcher Aisha D. , Ford Chandra L. 
Published: May 2024

Introduction
Coronavirus disease (COVID) dashboards rarely provide insights about the racialized contexts in which vaccination inequities occur.

Objective
The purpose of this study was to use the emerging Project REFOCUS dashboard to contextualize COVID vaccination patterns among 6 diverse communities.

Methods
We queried the dashboard to generate descriptive statistics on vaccination trends and racism-related contextual factors among the 6 Project REFOCUS pilot sites (Albany, Georgia, Bronx, New York, Detroit, Michigan, Helena-West Helena, Arkansas, San Antonio, Texas, and Wake County, North Carolina).

Results
Vaccination rates, demographic indicators, and contextual factors differed across sites. As of October 17, 2022, the proportion of people who had received at least 1 COVID vaccine dose ranged from 58.4% (Wayne County, Michigan) to 95.0% (Wake County, North Carolina). The pilot sites with the greatest percentage of Black residents (Dougherty County, Georgia, Wayne County, Michigan, and Phillips County, Arkansas) had lower proportions of fully vaccinated people. Wayne County, Michigan, had the highest level of residential segregation between Black and White residents (78.5%) and non-White and White residents (68.8%), whereas Phillips County, Arkansas, had the highest overall mortgage denial rates (38.9%). Both counties represent settings where over 75.0% of residents report Black race and over 30.0% of the population live in poverty.

Discussion
The dashboard integrates racism-related factors with COVID vaccination visualizations and provides a fuller picture of the context in which COVID trends are occurring.

Conclusions
Community organizers, researchers, policymakers, and practitioners can track racism-related factors and other social determinants of health as part of the contexts in which COVID-related inequities occur.