bluuebunny/crossref_metadata_2025_split huggingface dataset:
“GO” to move toward dementia‐friendly communities: A pilot study
Authors: Iizuka Ai , Ura Chiaki , Yamashita Mari , Ito Koki , Yamashiro Miyuko , Okamura Tsuyoshi 
Published: June 2024

AbstractBackgroundTo the creation of mutual aid relationships among people with cognitive decline is important in aging societies. This study aimed to develop and examine the feasibility of a GO Program in which older adults, with experience in playing GO, support the learning of GO by older adults with cognitive decline and other barriers to social participation, which in turn reduces social isolation and creates opportunities for older adults to use their role.MethodsThis single‐arm intervention study was conducted in Tokyo, Japan. Introductory GO classes were held for 10 participants who had never played GO (beginners) and 10 participants who had (supporters) once a week for an hour, for a total of 12 sessions. Supporters and beginners were paired to solve problems and play games. We assessed the feasibility of the program and its effects on mental health social network, and cognitive function.ResultsCognitive test scores were at the mild cognitive Impairment level for beginners as well as for supporters. Satisfaction with the program was high, with an overall class attendance rate of 99.1% and none leaving the program. No significant changes were observed over time for beginners in each measurement; however, there was a significant improvement in the Mini Mental State Examination‐Japanese scores for supporters (p < .05).ConclusionsThe results suggest that this program could contribute to the creation of mutual aid relationships among older adults with cognitive decline; even if they have mildly declined cognitive function, they can still play an active role in society. Moreover, creating such opportunities may positively impact cognitive function.
The altered functional status in vestibular migraine: A meta‐analysis
Authors: Du Junyong , Liu Yong , Zhu Wenhao 
Published: June 2024

AbstractPurposeVestibular migraine (VM) is a disorder with prominent vestibular symptoms that are causally correlated with migraine and is the most prevalent neurological cause of episodic vertigo. Nevertheless, the functional underpinnings of VM remain largely unclear. This study aimed to reveal concordant alteration patterns of functional connectivity (FC) in VM patients.MethodsWe searched literature measuring resting‐state FC abnormalities of VM patients in PubMed, Embase, Cochrane, and Scopus databases before May 2023. Furthermore, we applied the anisotropic effect size‐signed differential mapping (AES‐SDM) to conduct a whole‐brain voxel‐wise meta‐analysis to identify the convergence of FC alterations in VM patients.ResultsNine studies containing 251 VM patients and 257 healthy controls (HCs) were included. Relative to HCs, VM patients showed reduced activity in the left superior temporal gyrus and left midcingulate/paracingulate gyri, and increased activity in the precuneus, right superior parietal gyrus, and right middle frontal gyrus. Jackknife's analysis and subgroup analysis further supported the generalization and robustness of the main results. Furthermore, meta‐regression analyses indicated that the Dizziness Handicap Inventory (DHI) ratings were positively correlated with the activity in the precuneus, while higher Headache Impact Test‐6 and DHI scores were associated with lower activity within the left midcingulate/paracingulate gyri.ConclusionsThe study indicates that VM is associated with specific functional deficits of VM patients in crucial regions involved in the vestibular and pain networks and provides further information on the pathophysiological mechanisms of VM.
Associations between atypical intracortical myelin content and neuropsychological functions in middle to older aged adults with ASD
Authors: Kohli Jiwandeep S. , Linke Annika C. , Martindale Ian A. , Wilkinson Molly , Kinnear Mikaela K. , Lincoln Alan J. , Hau Janice , Shryock Ian , Omaleki Vinton , Alemu Kalekirstos , Pedrahita Stephanie , Fishman Inna , Müller Ralph‐Axel , Carper Ruth A. 
Published: June 2024

AbstractIntroductionIn vivo myeloarchitectonic mapping based on Magnetic Resonance Imaging (MRI) provides a unique view of gray matter myelin content and offers information complementary to other morphological indices commonly employed in studies of autism spectrum disorder (ASD). The current study sought to determine if intracortical myelin content (MC) and its age‐related trajectories differ between middle aged to older adults with ASD and age‐matched typical comparison participants.MethodsData from 30 individuals with ASD and 36 age‐matched typical comparison participants aged 40–70 years were analyzed. Given substantial heterogeneity in both etiology and outcomes in ASD, we utilized both group‐level and subject‐level analysis approaches to test for signs of atypical intracortical MC as estimated by T1w/T2w ratio.ResultsGroup‐level analyses showed no significant differences in average T1w/T2w ratio or its associations with age between groups, but revealed significant positive main effects of age bilaterally, with T1w/T2w ratio increasing with age across much of the cortex. In subject‐level analyses, participants were classified into subgroups based on presence or absence of clusters of aberrant T1w/T2w ratio, and lower neuropsychological function was observed in the ASD subgroup with atypically high T1w/T2w ratio in spatially heterogeneous cortical regions. These differences were observed across several neuropsychological domains, including overall intellectual functioning, processing speed, and aspects of executive function.ConclusionsThe group‐level and subject‐level approaches employed here demonstrate the value of examining inter‐individual variability and provide important preliminary insights into relationships between brain structure and cognition in the second half of the lifespan in ASD, suggesting shared factors contributing to atypical intracortical myelin content and poorer cognitive outcomes for a subset of middle aged to older autistic adults. These atypicalities likely reflect diverse histories of neurodevelopmental deficits, and possible compensatory changes, compounded by processes of aging, and may serve as useful markers of vulnerability to further cognitive decline in older adults with ASD.
Identifying victim types in sexual homicide: A latent class analysis using interactional victimology theories
Authors: Georgoulis Hana , Beauregard Eric , Chopin Julien 
Published: June 2024

AbstractSexual homicide (SH) research has focused on those who commit these crimes and the crimes themselves. This leaves the victim, an equally crucial piece to the puzzle, left as a sort of afterthought, despite the valuable insight that victimology provides to the crime. For the current study, victim information related to their routine activities and lifestyles was taken from an international database containing 662 solved cases of SH. Nine victim variables were used in a latent class analysis to find hidden subgroups within the victim population. Three classes were identified—low‐risk, homebody, and overt risk victims—which suggests that SH victimization varies depending on the victim lifestyles and routine activities. These groups were externally validated by examining their association with different phases of the crime commission process. Some sexual homicide offenders may be more drawn to a victim because they present as vulnerable and opportunistic, while others might be methodically targeted. The theoretical relevance of this typology, along with investigative and prevention strategies, is discussed.
Predictive factors for peripheral blood stem cell mobilization in multiple myeloma in the era of novel therapies: A single‐center experience
Authors: He Xiao , Jiang Duanfeng , Zhao Liang , Chen Shuping , Zhu Yan , He Qun , He Yanjuan 
Published: June 2024

AbstractObjectiveMultiple myeloma (MM) is the leading indication of autologous hematopoietic stem cell transplantation. The aim of this study was to determine the incidence of mobilization failure and characterize the risk factors associated with poor mobilization (PM) of MM patients in novel therapies era.MethodsWe conducted a retrospective study of 211 MM patients who received their first peripheral blood stem cells (PBSC) mobilization at our single center. The following data were collected: age, gender, clinical stage, disease status, complete blood cell count, induction regimen, CD34+ cell count in peripheral blood (PB), and PBSC collections.ResultsIn addition to conventional drugs, 22 (10.4%) patients received daratumumab containing induction, and 33 (15.6%) patients used plerixafor for poor mobilization (pre‐apheresis PB CD34+ cells <20/μL). Failure of collection occurred in 24 (11.4%) patients and was correlated with low white blood cell (WBC), ≥3 cycles of lenalidomide treatment before mobilization, steady‐state mobilization and nouse of plerixafor are associated with mobilization failure. Daratumumab‐based induction treatment ≥2 courses, albumin >41 g/L before mobilization, and steady‐state mobilization were risk factors for PM in subgroups of patients treated with lenalidomide for <3 courses. In addition, Hepatitis B virus infection at baseline, thalassemia and measurable residual disease positivity were recognized as predictive factors for PM in subset of chemo‐mobilization patients.ConclusionIn addition to some well‐recognized risk factors, baseline WBC count and daratumumab exposure ≥2 courses before mobilization were revealed as the predictive factors of mobilization failure, providing consultation for preemptive use of plerixafor.
Survival outcome and predictors of WHO grade 2 and 3 insular gliomas: A classification based on the tumor spread
Authors: Xue Bowen , Hou Zonggang , Deng Zhenghai , Sun Shengjun , Zhang Chuanhao , Pan Yuesong , Zhang Yazhuo , Li Zhenye , Xie Jian 
Published: June 2024

AbstractObjectiveThe study aimed to identify if clinical features and survival outcomes of insular glioma patients are associated with our classification based on the tumor spread.MethodsOur study included 283 consecutive patients diagnosed with histological grade 2 and 3 insular gliomas. A new classification was proposed, and tumors restricted to the paralimbic system were defined as type 1. When tumors invaded the limbic system (referred to as the hippocampus and its surrounding structures in this study) simultaneously, they were defined as type 2. Tumors with additional internal capsule involvement were defined as type 3.ResultsTumors defined as type 3 had a higher age at diagnosis (p = 0.002) and a higher preoperative volume (p < 0.001). Furthermore, type 3 was more likely to be diagnosed as IDH wild type (p < 0.001), with a higher rate of Ki‐67 index (p = 0.015) and a lower rate of gross total resection (p < 0.001). Type 1 had a slower tumor growth rate than type 2 (mean 3.3%/month vs. 19.8%/month; p < 0.001). Multivariate Cox regression analysis revealed the extent of resection (HR 0.259, p = 0.004), IDH status (HR 3.694, p = 0.012), and tumor spread type (HR = 1.874, p = 0.012) as independent predictors of overall survival (OS). Tumor grade (HR 2.609, p = 0.008), the extent of resection (HR 0.488, p = 0.038), IDH status (HR 2.225, p = 0.025), and tumor spread type (HR 1.531, p = 0.038) were significant in predicting progression‐free survival (PFS).ConclusionThe current study proposes a classification of the insular glioma according to the tumor spread. It indicates that the tumors defined as type 1 have a relatively better nature and biological characteristics, and those defined as type 3 can be more aggressive and refractory. Besides its predictive value for prognosis, the classification has potential value in formulating surgical strategies for patients with insular gliomas.
Thermal Inactivation, Denaturation and Aggregation Processes of Papain‐Like Proteases
Authors: Koroleva Victoria , Lavlinskaya Maria , Holyavka Marina , Penkov Nikita , Zuev Yuriy , Artyukhov Valeriy 
Published: June 2024

AbstractThe investigation into the behavior of ficin, bromelain, papain under thermal conditions holds both theoretical and practical significance. The production processes of medicines and cosmetics often involve exposure to high temperatures, particularly during the final product sterilization phase. Hence, it′s crucial to identify the “critical” temperatures for each component within the mixture for effective technological regulation. In light of this, the objective of this study was to examine the thermal inactivation, aggregation, and denaturation processes of three papain‐like proteases: ficin, bromelain, papain. To achieve this goal, the following experiments were conducted: (1) determination of the quantity of inactivated proteases using enzyme kinetics with BAPNA as a substrate; (2) differential scanning calorimetry (DSC); (3) assessment of protein aggregation using dynamic light scattering (DLS) and spectrophotometric analysis at 280 nm. Our findings suggest that the inactivation of ficin and papain exhibits single decay step which characterized by a rapid decline, then preservation of the same residual activity by enzyme stabilization. Only bromelain shows two steps with different kinetics. The molecular sizes of the active and inactive forms are similar across ficin, bromelain, and papain. Furthermore, the denaturation of these forms occurs at approximately the same rate and is accompanied by protein aggregation.
Paeoniae Radix Rubra: A Review of Ethnopharmacology, Phytochemistry, Pharmacological Activities, Therapeutic Mechanism for Blood Stasis Syndrome, and Quality Control
Authors: Fan Zuowang , Liu Jing , Wang Xu , Yang Saisai , Wang Qi , Yan Li , Zhang Yao , Wu Xiuhong 
Published: June 2024

AbstractPaeoniae Radix Rubra (PRR) known as Chishao, in China, is the dried root of Paeonia lactiflora Pall. or Paeonia veitchii Lynch, with a history of over 2000 years in traditional Chinese medicine, is employed to clear heat, cool the blood, dispel blood stasis, and alleviate pain. Phytochemical investigations identified 264 compounds that contained monoterpenes and their glycosides, sesquiterpenes, triterpenes, steroids, flavonoids, lignans, tannins, volatile oils, and other compounds. It has been reported to have different pharmacological activities, including cardiovascular‐protective, antidepressive, neuroprotective, antitumor, hepatoprotective, and anti‐inflammatory effects. This study offers a comprehensive review covering ethnopharmacology, phytochemistry, pharmacological activities, therapeutic mechanism for blood stasis syndrome, and quality control of PRR. The comprehensive analysis aims to achieve a thorough understanding of its effects and serves as a foundation for future research and development.
The Post‐Polyketide Synthase Modification Mechanism in Hitachimycin Biosynthesis
Authors: Kudo Fumitaka , Tsuboi Kazuma , Ikezaki Mutsumi , Nagayama Daiki , Kawamura Koichi , Ando Taishi , Miyanaga Akimasa , Eguchi Tadashi 
Published: June 2024

AbstractHitachimycin is a bicyclic macrolactam antibiotic with (S)‐β‐phenylalanine (β‐Phe) at the starter position of the polyketide skeleton. While the enzymes that recognize β‐amino acids, modify the aminoacyl groups, and transfer the resultant dipeptide groups to the acyl carrier protein domains of polyketide synthases (PKSs) have been studied extensively, the post‐PKS modification mechanism responsible for constructing the unique bicyclic structure of hitachimycin remains elusive. In this study, we first inactivated six genes encoding putative post‐PKS modification enzymes, namely hitM1 to hitM6, in Streptomyces scabrisporus to determine their involvement in hitachimycin biosynthesis. The ΔhitM4 strain accumulated an all‐trans‐2,4,6,8,18‐pentaene macrolactam, which was confirmed as a true intermediate in hitachimycin biosynthesis by cellular feeding experiments, and appears to be the initial intermediate in the post‐PKS modification pathway. The ΔhitM1 strain accumulated 10‐O‐demethyl‐10‐oxohitachimycin (M1‐A). In enzymatic experiments, M1‐A was reduced by the NAD(P)H‐dependent reductase HitM1 in the presence of NADPH. The product of the reaction catalyzed by HitM1 was converted to hitachimycin by the methyltransferase HitM6. We thus propose a plausible post‐PKS modification mechanism for the biosynthesis of hitachimycin.
Controllable Silver Release for Efficient Treatment of Drug‐Resistant Bacterial‐Infected Wounds
Authors: Shi Yanfeng , Wang Lupeng , Song Siqi , Liu Miao , Zhang Pengfei , Zhong Di , Wang Yanjing , Niu Yusheng , Xu Yuanhong 
Published: June 2024

AbstractThe use of traditional Ag‐based antibacterial agents is usually accompanied by uncontrollable silver release, which makes it difficult to find a balance between antibacterial performance and biosafety. Herein, we prepared a core‐shell system of ZIF‐8‐derived amorphous carbon‐coated Ag nanoparticles (Ag@C) as an ideal research model to reveal the synergistic effect and structure‐activity relationship of the structural transformation of carbon shell and Ag core on the regulation of silver release behavior. It is found that Ag@C prepared at 600 °C (AC6) exhibits the best ion release kinetics due to the combination of relatively simple shell structure and lower crystallinity of the Ag core, thereby exerting stronger antibacterial properties (>99.999 %) at trace doses (20 μg mL−1) compared with most other Ag‐based materials. Meanwhile, the carbon shell prevents the metal Ag from being directly exposed to the organism and thus endows AC6 with excellent biocompatibility. In animal experiments, AC6 can effectively promote wound healing by inactivating drug‐resistant bacteria while regulating the expression of TNF‐α and CD31. This work provides theoretical support for the scientific design and clinical application of controllable ion‐releasing antibacterial agents.
Posterior scleritis following a single infusion of zoledronate for osteoporosis: A case report and literature review
Authors: Ma Dingling , Xiao Can , Zhao Deshui , Li Guohua , Cheng Wei , Deng Xin , He Dan , Liu Kai 
Published: June 2024

Key Clinical MessageThe most frequently reported adverse reaction to zoledronic acid is an acute phase reaction resembling influenza. While rarer adverse events such as osteonecrosis of the jaw and atypical femoral fractures have gained significant recognition, the ocular adverse effects, particularly scleritis, are not yet fully comprehended. Here, we present the case of a 75‐year‐old female patient with osteoporosis who developed bilateral redness and intense eye pain 48 h after receiving a 5 mg intravenous dose of zoledronic acid. Clinical presentation suggested bilateral conjunctivitis, but treatment with levofloxacin eye drops and acyclovir ophthalmic gel exacerbated the symptoms over 2 days, predominantly affecting the left eye. Ocular ultrasonography revealed thickening of the left eyeball wall with a “T” sign, while an orbital CT scan showed increased thickness of the left sclera. Treatment with methylprednisolone 80 mg intravenous infusion twice daily led to gradual symptom improvement and eventual resolution of inflammation. This report, based on a review of relevant literature, investigates the treatment and outcomes of zoledronic acid‐induced scleritis, emphasizing the importance for clinicians to promptly identify and manage this rare and serious ocular adverse reaction.
Oxygen‐Tolerant CO2 Electrocatalysis
Authors: Zhu Hong‐Jing , Guo Hui , Cao Rong , Huang Yuan‐Biao 
Published: June 2024

AbstractThe electrochemical carbon dioxide reduction reaction (CO2RR) to generate high‐value products is considered to be a promising approach to reduce the atmospheric concentration of CO2. However, the pure CO2 gas is generally required in the most of the reported CO2RR system, which brings tedious capture and separation procedures and high cost. The utilization of realistic CO2 emission directly such as flue gas for the CO2RR is highly desirable. However, the gas impurities in the real CO2 sources such as oxygen could seriously affect the activity and selectivity of the CO2RR. This concept summarizes the recently reported works about CO2RR studies in the presence of O2 and highlights the physical and chemical strategies to boost CO2 electroreduction performance. We further discuss the implications of these strategies for future progress in this emerging field.
Low‐Temperature Hydrogenation of Carboxylic Acids to Alcohols over Heterogeneous FeOx‐Modified Ru Catalyst
Authors: Tamura Masazumi , Chen Pengru , Umehara Yumi , Onodera Wataru , Akatsuka Masato , Kita Yusuke 
Published: June 2024

AbstractSelective hydrogenation of carboxylic acids to alcohols is generally difficult due to the low reactivity of the carboxy group, and the development of effective catalysts enabling high yields of the target alcohols at low reaction temperatures (<473 K) is challenging. Herein, we found that SiO2‐supported FeOx‐modified Ru (Ru−FeOx/SiO2) with the Fe/Ru molar ratio of 0.4 was an effective and reusable heterogeneous catalyst for the hydrogenation of carboxylic acids at a low reaction temperature of 413 K, providing the alcohols in high yields (up to 97 %). The addition of Fe species drastically suppressed the hydrogenolysis of the C−C bond of the alkyl chain to methane, leading to high selectivity to the alcohols. Based on the activity tests and catalyst characterizations, Ru metals were covered by the reduced Fe species, such as Fe metal or Fe2+, and the active site is the interface between the Fe species and Ru metals. From the reactivity comparison of the related compounds, the alcohol is synthesized via the formation of the aldehyde, and the reactivity of the alcohol is very low in the presence of carboxylic acids. As a result, the hydrogenolysis of the produced alcohol is suppressed, leading to the high selectivity of the alcohol.
Robust Junction Formation of Copper(I) Oxide on Graphitic Carbon Nitride Enhances Aqueous Carbon Dioxide Photoreduction without Sacrificial Reagents
Authors: Choi Byeonghoon , Lim Chan Kyu , Kim Minjun , Bang Kodong , Park Bumjin , Lee Hee‐Seung , Song Hyunjoon 
Published: June 2024

AbstractSemiconductor hybrid structures containing multiple components have been considered an ideal photocatalyst design to generate long‐lived charge‐separated states. The reaction activity is highly susceptible to the catalyst component and morphology, particularly for the reactions requiring high activation energies, such as a CO2 reduction reaction (CO2RR). In this study, we selected g‐C3N4 and Cu2O as photocatalytic components having bandgaps suitable for CO2RR. Our approach involved establishing robust electric junctions between these domains by direct growth of Cu on g‐C3N4 via a polyol process. The resulting g‐C3N4/Cu2O hybrid was employed as photocatalysts in an aqueous medium without hole acceptors. The catalyst exhibited notable activities for CO (94 μmol gcat−1 h−1) and CH4 production (218 μmol gcat−1 h−1), maintaining stability for over 6 h. The inherent synergy between g‐C3N4 and Cu2O, facilitated by the formation of conductive junctions, enabled efficient electron transfer to promote CO2RR. These findings ensured the importance of junctions and interfaces in the hybrid catalyst structures for unlocking superior photocatalytic CO2RR performance.