bluuebunny/crossref_metadata_2025_split huggingface dataset:
„[…] [I]hre Bilderschätze mehr und mehr bekannt machen“: Zu den Fotokampagnen Victor Angerers und Josef Löwys in der Gemäldegalerie der Wiener Akademie
Authors: Cordts Viktoria 
Published: June 2024

Abstract
Das Kupferstichkabinett der Akademie der bildenden Künste Wien erweiterte 2022 seine Sammlungsbestände um Reproduktionsfotografien und Glasplattennegative zu Werken der Gemäldegalerie der Wiener Akademie, deren Erschließung neue Erkenntnisse zum Umgang hiesiger Kunstsammlungen mit Reproduktionsanfragen im letzten Drittel des 19. und zu Beginn des 20. Jahrhunderts lieferten. Die Bestände sollten der allgemeinen Öffentlichkeit sowie der kunstwissenschaftlichen Forschung zugänglich gemacht werden. Zugleich rückt die Arbeit der Fotografen Victor Angerer und Josef Löwy in den Fokus, deren Engagement mit dem Erhalt der Reproduktions- und Vervielfältigungsrechte zu den Werken der Akademiebildsammlung vornehmlich kommerziellen Interesses waren und die institutionellen Ziele in den Schatten stellten. Dies ließ sich auch an der Weiternutzung der Löwy-Negative durch den Kunstverlag Wolfrum bis in die 1920er Jahre nachweisen.
Epicardial fat thickness as a component of early vascular aging in patients with coronary artery disease with borderline coronary stenosis
Authors: Yakhontov D. A. , Ostanina Ju. O. , Lukinov V. L. 
Published: June 2024

Aim. To evaluate the incidence of early vascular aging (EVA) and epicardial fat thickness (EFT) in patients with stable coronary artery disease (CAD) with borderline stenosis.Material and methods. The study involved 201 patients with class 1-3 stable CAD with borderline (50-70%) stenosis. The first group consisted of 57 (28,4%) patients with increased EFT, the second (n=144 (71,6%)) — without increased EFT. EFT was determined by cardiac ultrasound. Vascular wall stiffness was assessed using a VaSera VS-1500N sphygmomanometer manufactured by FUKUDA DENSHI (Japan). Relative telomere length was determined by real-time PCR. All patients underwent coronary angiography.Results. The mean EFT in group 1 was 6,00 [5,00; 6,50] mm, in group 2 — 3,00 [2,30; 4,00] mm (p<0,001). In patients of group 1, hypertension (p<0,001), CAD (p<0,001) in general and myocardial infarction (p=0,003) in particular debuted at a younger age. In both groups, the incidence of obesity, type 2 diabetes, angina, and the intake rate of all four main groups of antianginal drugs did not differ significantly. Early vascular aging was significantly more often detected in the group of patients with stable CAD with borderline coronary artery stenosis and visceral obesity (p<0,001). Relative telomere length was shorter and pulse wave velocity was higher in this group (p<0,001).Conclusion. Patients with stable CAD with borderline stenosis and increased EFT have a higher incidence of EVA, despite the same incidence of obesity, diabetes, and functional class of angina as the group of patients without increased EFT.
Biomarkers of fibrosis and inflammation and the risk of arrhythmia recurrence after elective electrical cardioversion in patients with atrial fibrillation and metabolic syndrome
Authors: Barashkova E. I. , Ionin V. A. , Baranova E. I. 
Published: June 2024

Aim. To evaluate the effect of blood concentrations of biomarkers of inflammation and fibrosis, obesity parameters, and parameters characterizing cardiac remodeling on the risk of recurrent atrial fibrillation (AF) within 6 months after elective electrical cardioversion (ECV) in patients with metabolic syndrome (MS).Materials and methods. The study included patients with AF and MS (n=60) and with AF without MS (n=41), who underwent elective ECV. Prospective observation was carried out for 6 months.Results. Arrhythmia recurrence within 6 months after ECV in patients with AF in combination with MS is higher than without MS (34/60 and 9/41, p = 0.003). Among echocardiographic parameters, left atrial volume and volume index, and epicardial adipose tissue thickness (EAT) are associated with arrhythmia resumption in patients with MS and AF. Blood concentrations of galectin-3 (17.4 (12.8-19.6) and 13.3 (5.1-14.9), p=0.0001), connective tissue growth factor (CTGF) (163, 1 (134.1-232.2) and 156.7 (104.7 - 189.1), p=0.002), growth differentiation factor 15 (GDF-15) (2343.9 (1206.1-3254.2 ) and 986.1 (812.5-1775.5), p=0.0001) and interleukin-6 (IL-6) (3.8 (2.3-7.3) and 2.3 (1, 3-3.4), p=0001) in patients with MS with recurrent arrhythmia is higher than without arrhythmia. According to the ROC analysis of EAT, the concentration of galectin-3 and IL-6 in the blood was most predictive of relapse of AF in MS; threshold values of the predictors were established: EAT more than 6.1 mm, IL-6 more than 2.8 pg/ml, galectin-3 more than 15.9 ng/ml.Conclusion. In patients with AF combined with MS, the frequency of maintaining sinus rhythm after effective ECV for 6 months is lower than in patients without MS. Epicardial adipose tissue thickness, high concentrations of galectin-3 and IL-6 are associated with relapse of AF in patients with MS.
Masked uncontrolled hypertension in patients with impaired carbohydrate metabolism
Authors: Nazarova V. V. , Antropova O. N. , Osipova I. V. , Zhuravleva A. N. , Semenova M. I. 
Published: June 2024

Aim. To establish the prevalence of masked uncontrolled hypertension (HTN) (MUH) in patients with diabetes or impaired glucose tolerance (IGT) and determine its clinical and hemodynamic characteristics.Material and methods. The study involved 87 patients who received regular antihypertensive therapy for hypertension and had established diabetes or IGT. The mean age of patients was 62,6±9,9 years, of which 51,7% were women, 48,3% — men. Type 2 diabetes was revealed in 77,7%, IGT — 22,8% of patients. For 24-hour blood pressure monitoring, BpLAB system (OOO Petr Telegin) was used; blood pressure (BP) was determined in the brachial artery, central blood pressure — in the aorta. We analyzed risk factors and target organ damage. The results were processed using the Excel Microsoft Office 2007 package and the Statistica 6.0 and 10.0 package from StatSoft, Inc (USA).Results. Uncontrolled hypertension was revealed in 59,8%, MUH — in 18,4%, controlled HTN — 21,8% of patients. Mean daytime and mean nighttime systolic BP in patients with MUH and uncontrolled HTN were comparable. Patients with controlled hypertension compared with MUH had lower mean day- and nighttime aortic BP by 27,1% (p<0,01) and 16,8% (p<0,01), respectively. Aortic BP was comparable in individuals with MUH and uncontrolled HTN. Asymptomatic hyperuricemia was more common in patients with uncontrolled HTN compared with MUH and controlled hypertension by 29,3% and 41,8%, respectively. With MUH, compared with controlled HTN, we revealed a higher incidence of stroke by 18,8%, a decrease in glomerular filtration rate <60 ml/min by 17,5%, albuminuria by 18,8%, left ventricular hypertrophy by 2,6 times.Conclusion. Only 41,2% of patients with diabetes and prediabetes achieve the target office BP level, while every second of these patients has MUH. MUH, compared with controlled HTN, is characterized by a higher incidence of stroke, kidney (decrease in glomerular filtration rate <60 ml/min and albuminuria) and heart damage (left ventricular hypertrophy).
Non-alcoholic fatty liver disease and ultrasound markers of obesity as unfavorable factors in the course of coronary artery disease
Authors: Tsygankov D. A. , Polikutina O. M. 
Published: June 2024

Aim. To evaluate the association of non-alcoholic fatty liver disease (NAFLD) with markers of visceral obesity in patients with coronary artery disease (CAD).Material and methods. We examined 125 patients hospitalized in the emergency cardiology department with CAD (female — 41,6%, male — 58,4%) and body mass index of 18,5-35,0 kg/m2. The median age of the subjects was 68 [61,0;74,0] years. We assessed following ultrasound parameters of visceral obesity: intraabdominal fat thickness (IAFT), abdominal wall fat index (WFI), preperitoneal fat thickness (PFT), subcutaneous adipose tissue (SAT), represented by MinSAT and MaxSAT. The following liver parameters were assessed: anteroposterior dimension of the left lobe and oblique-vertical dimension of the right lobe. Statistical data processing was carried out using the Statistica 6.0 program. Quantitative variables are presented as median (Me). Percentiles (25%; 75%) were used as dispersion measures. The influence of several predictors was assessed using linear regression analysis.Results. In patients without echographic signs of hepatic steatosis, the IAFT was 50,5 [30,7;65,0] mm and significantly increased with increasing hepatosis degree: from 45,0 [24,0;63,0] mm in respondents with grade 1 to 67,5 [34,0;76,0] mm with grade 3 (p=0,010). PFT also significantly increased from 11,5 [8,9;13,3] mm in individuals without hepatic steatosis to 13,8 [10,7;15,6] mm in those with grade 1, 18,5 [13,0;22,4] mm in those with grade 2 and 23,5 [13,0;29,4] mm in those with grade 3 hepatic steatosis (p=0,001). MinSAT and MaxSAT also increased, but not significantly (from 11,5 [8,8;15,9] to 20,4 [10,1;27,3] mm, p=0,151 and from 14,0 [11,4;25,4] mm to 22,4 [15,0;25,0] mm, p=0,576, respectively). The increase in WFI was also not significant. Linear regression analysis confirmed that hepatic steatosis was associated with IAFT increase (b=9,3, p=0,012).Conclusion. NAFLD is associated with factors influencing the CAD course — hyperglycemia, lipid metabolism disorders, as well as ultrasound markers of obesity. An increase in liver size was associated with an increase in BMI, glucose, triglycerides, high-density lipoproteins and ultrasound markers of obesity — IAFT and PFT. NAFLD in patients with CAD was associated with increased IAFT and PFT. In addition, 52,5% of people with normal body weight had NAFLD, which once again indicates the ineffectiveness of this indicator for stratifying the risk of development and progression of cardiovascular disease and the need for routine screening of NAFLD in people with cardiovascular diseases, regardless of BMI.
2023 All-Russian screening for hypertension: results
Authors: Rotar O. P. , Ilyanova I. N. , Boyarinova M. A. , Moguchaya E. V. , Tolkunova K. M. , Dyachkov V. A. , Rubanenko O. A. , Rubanenko A. O. , Gaberman O. E. , Gubareva E. Yu. , Pomogaibo B. V. , Dolya E. M. , Kaliberdenko V. B. , Avdeeva I. V. , Tomashevskaya Yu. A. , Falkovskaya A. Yu. , Manukyan M. A. , Solonskaya E. I. , Vtorushina A. A. , Khunkhinova S. A. , Tsareva V. M. , Molokoedova L. E. , Petrova M. M. , Kaskaeva D. S. , Romanova I. V. , Danilova L. K. , Evsyukov A. A. , Tutyrina O. V. , Tepnadze L. E. , Yakunchenko T. I. , Mevsha O. V. , Sharapova Yu. A. , Chernykh T. M. , Syomkina E. V. , Tsygankova O. V. , Protasov K. V. , Fedorishina O. V. , Makeeva E. R. , Smolkina Y. A. , Nikishina D. D. , Verushkina A. S. , Smirnova E. A. , Belenikina Ya. A. , Bikushova I. V. , Derevyanchenko M. V. , Fedotov V. V. , Shaposhnikova M. Yu. , Sereda D. V. , Kartashova E. A. , Zheleznyak E. I. , Rakhmatullina D. M , Kiseleva L. S. , Evsevieva M. , Sergeeva O. V. , Kudryavtseva V. D. , Zavyalova A. M. , Slezova V. I. , Kitalaeva K. T. , Artemov N. N. , Tanicheva A. A. , Konradi A. A. , Shlyakhto E. V. 
Published: June 2024

Aim. To assess awareness of blood pressure (BP) level, adherence to therapy and achievement of target BP in residents of Russian regions as part of the 2023 hypertension (HTN) screening campaign.Material and methods. During May 2023, 4613 participants from 23 cities of Russia took part in the screening. Participation was voluntary without restrictions on sex. All patients aged over 18 years. During screening, BP and pulse were measured three times using automatic or mechanical BP monitors, and a questionnaire about behavioral risk factors, concomitant diseases and therapy was filled out. HTN was diagnosed with systolic BP ≥140 mm Hg and/or diastolic BP ≥90 mm Hg and/or taking antihypertensive therapy (AHT).Results. The analysis included data from 4585 respondents aged 18 to 95 years with an average age of 45 [28;59] years, of which 1729 were men (37,7%). The proportion of hypertensive patients was 49,6%. Among them, 62,8% took AHT and achieved target BP in 76,6% and 45,7% with the target BP criterion <140/90 mm Hg and <130/80 mm Hg, respectively. Most patients took dual AHT (37,4%), while monotherapy and triple therapy was registered in 27,5% and 23,4%, respectively. Initiation of therapy was performed with combination AHT in 43,7% of patients with HTN and 41,4% are currently using fixed-dose combination therapy. On-demand therapy was the most common reason for skipping medications and was more common in women, while men more often cited the high drug cost and a history of adverse reactions. Among patients with HTN, home BP measurement was associated with a higher prevalence of achieving target BP as follows: 1000 (60%) vs 100 (17%), p<0,001.Conclusion. The data obtained indicate, on the one hand, a continuing insufficient level of awareness about high BP and the use of antihypertensive drugs among the population, but there is a tendency to improve the effectiveness of the treatment of hypertension, including the use of fixed-dose combinations of antihypertensive drugs.
A systematic review on the impact of interventions on gene expression profiles of rheumatoid arthritis patients
Authors: Shaham N Muhammad , Das Partha Pratim , Haque M Ijasul , Khanna Manish 
Published: June 2024

Rheumatoid arthritis (RA) is an autoimmune inflammatory disease with a poorly known aetiology. Although the primary characteristic of RA is inflammation, other biological systems are implicated in various phases of the disease. Interventions and their impact on gene expression in active RA patients is currently playing a significant role in the development of specific treat to target techniques. The present study aims toevaluate the effect of various reported interventions on gene expression in rheumatoid arthritis patients. Publicly available English databases, PubMed and Google Scholar, were queried from 2020 to 2023. We mined a total of 1970 research documents, of which 8 articles were selected based on the inclusion and exclusion criteria. The review analyzed therapeutics, including anti-TNF alpha-blockers, GM-CSF blockers, Chemokine receptor blockers and herbal Ginger in RA treatment and prediction of responders and non-responders based on gene expression analysis. However, due to the mixed-use of samples, experimental methodologies, analysis tools and genes studied in the studies, our comparison is inconclusive in determining effective therapy. The study highlights the necessity of harmonization in order for gene expression profiles to be effectively used as a clinical tool in RA patients' personalized medication.
Functional outcome of chronic osteomyelitis treated by sequestrectomy & saucerisation with antibiotic bead implantation
Authors: Jha Vikash Kumar , Zacarias Tomin P , Bharali Kaushik , Dutta Swapnaneel 
Published: June 2024

Chronic Osteomyelitis has been treated since inception of Orthopaedics, however a ideal treatment eliminating the disease doesn’t exist. Numerous treatment modalities & Surgical procedures have been tried with varied results, owing to the chronic nature of the infection, virulence of organism and complex pathogenesis. With time, the antibiotic delivery to target site has expanded to include effective oral agents and local therapy with antibiotics mixed in bone cement or use of biodegradable antibiotic impregnated materials. This study intends to obtain factors which influence the incidence of osteomyelitis in the population & also to know the common means of transmission of bony infection, further identification of the major areas of disease manifestations and means of eradication of the same by our procedure. We conducted a prospective randomized control study on patients diagnosed with chronic osteomyelitis in the age group of 4- 60 years. 30 patients were treated with sequestrectomy and saucerisation & dead space filling with biodegradable antibiotic impregnated calcium sulphate beads for local delivery of antibiotics. The calcium sulfate used in this study was The STIMULAN KIT. This bone void filler kit consists of surgical-grade calcium sulfate powder and a sodium chloride diluent with Vancomycin as the broad spectrum antibiotic.: Functional outcome was evaluated using Enneking Functional Evaluation System which is a 30 point system for both upper and lower limbs. X-rays were used to evaluate the dead space volume (in cc) and bone repair (in %). Each patients were followed up for minimum of six months. The mean score for functional outcome was found to be 29.93. In 18 patients osteomyelitis occurred by hematogenous spread (60%) by superficial skin infection, Mean age of 13 patients (43.3%) were in the age group of 4-10 years. 63.3% of affected individuals were male. Most common site of infection was found to be tibia (33.3%) & most of the culture report from infection site showed no growth(90%). Complications such as prolonged ooze was seen in 15.9% cases. On Statistical analysis of the functional outcome, p value was found to be significant &#60; 0.001.Antibiotics containing beads (Stimulan Kit) is effective in the treatment of chronic osteomyelitis and in preventing the recurrence of infection. It is imperative to identify various factors responsible for the recurrence of infection. This may help clinicians predict the prognosis of the disease and minimise the risk of adverse outcomes.
A study of risk factors for Pott’s disease
Authors: Katkar Minish Raghunath , Chandanwale Ajay , Zad Shreyas , Deshpande Sandeep , Mangwalkar Vishal Anand 
Published: June 2024

Pott’s spine is caused by Mycobacterium tuberculosis, a slow growing gram-positive, acid-fast bacillus which becomes lodged in the bone via Batson’s venous plexus and lymphatic from primarily infected lung, lymph nodes, mediastinum and viscera, forming granulomatous inflammation and caseation necrosis. Pott's spine accounts for 2% of all cases of TB, 15% of extrapulmonary, and 50% of skeletal TB. The paradiscal, central, anterior subligamentous, and neural arch are the common vertebral lesions. Thoracic vertebrae are commonly affected followed by lumbar and cervical vertebrae. Predisposing factors for tuberculosis include poverty, overcrowding, illiteracy, malnutrition, alcoholism, drug abuse, diabetes mellitus, immunosuppressive treatment, and HIV infection. These are also predisposing factors for spinal tuberculosis. Older age, female gender, chronic peritoneal dialysis, household crowding and previous tuberculous infection were identified as risk factors for Pott’s spine. (10G) Additionally, vitamin D deficiency has been linked to an increased risk of spinal bone loss and an increased risk of spinal fractures in individuals with Pott’s spine. : To identify and evaluate the risk factors for Pott’s spine. : Present study was prospective in nature conducted among 441 patients of Pott’s spine. All patients fulfilling inclusion criteria and exclusion criteria were taken up for the study. Study was carried out over a period of 3 years. Serum Vitamin D was assessed.: Majority of the patients was in the age group of 41-50 years and most of them were male. In this study, we found that age, socioeconomic status, employment, presence of comorbidities and BMI(&#60;18) were associated with increased risk of pott’s spine.: This cross-sectional study investigates 441 cases of intervertebral disc degeneration leading to disc bulge/protrusion/extrusion, focusing on demographic, socioeconomic, and health-related factors. The majority of cases (31.82%) occurred in individuals aged 41-50 years, with females accounting for a larger proportion (54.55%) than males. Religious demographics revealed a prevalence of Muslims (45.57%) and Hindus (42.17%), with bilateral involvement common. A substantial portion of patients resided in slum areas (60.09%), reflecting socioeconomic disparities, with the majority (60.31%) belonging to the lower socioeconomic status. Most patients reported symptoms lasting less than 6 months (61.36%) and came from families with 5 or more members (85.48%). Addiction history (78.45%) and pre-existing co-morbidities (65.75%) were prevalent. Notably, no significant associations were found between serum Vitamin D levels and demographic factors. Among the employed, a significant proportion were unemployed (31.97%), underscoring socioeconomic challenges. These findings provide comprehensive insights into the multifaceted nature of intervertebral disc degeneration, crucial for informing targeted interventions and management strategies.
MRI vs arthroscopy in the diagnosis of meniscal tears: A comparative study
Authors: Sajjanshetty Rajesh , Ranjolkar Rohit 
Published: June 2024

The diagnostic accuracy of magnetic resonance imaging (MRI) for meniscal tears has not been adequately investigated, although it has been utilized extensively. By contrasting MRI results with arthroscopy findings, we hoped to gauge MRI's diagnostic precision. Investigating the incidence of ACL and meniscal tears; establishing a correlation between arthroscopy and MRI findings by calculating the specificity, sensitivity, positive and negative predictive values (with arthroscopy highly esteemed); grading the degree of subluxation; and ascertaining the minimal quantity of fluid that ought to be present in the knee. The MRI of forty patients in the age range of twenty to forty years old and twelve arthroscopic correlations was evaluated in the year 2021-2022. In percentage form, the sensitivity, specificity, PPV, and NPV were calculated. For MM, the ACL results were 87.87, 81.57, 80.55, and 88.57, whereas for LM, they were 77.77, 81.81, 72.41, and 85.71. One patient had anterior tibial subluxation, which accounted for 35.6% of all cases. Joint fluid was seen in 201 cases when the suprapatellar pouch appeared laterally with internal disruption. Patients with ACL injuries should be carefully evaluated during arthroscopy since preoperative MRI has a limited diagnostic accuracy.
The Kapandji pinning: Technique of closed reduction for distal end radius fracture in adults
Authors: Sanil Nibin , Sajan Alvin 
Published: June 2024

: Fractures of the distal end of radius are characterized by varying degrees of comminution with volar or dorsal displacement, articular depression and angulation of major fragments with or without involvement of joints. The technique that has been discussed most frequently is the intrafocal (Kapandji) technique. Initially the technique was described using two pins for unstable extra-articular fractures in younger adults. The indications have since been expanded to include fractures with minimally displaced intra-articular fragments and use of third pin dorsoulnarly.: 40 adults with distal radius fracture admitted to Sanjay Gandhi institute of trauma and orthopaedics. All patients will be evaluated at 4, 6 weeks intervals and once at 3 months post operatively and final outcome assessments at 3 months. For functional evaluation, the modified Gartland and Werley demerit point system. The results were evaluated as per Sarmiento’s Modification of Lindstrom criteria. Restoration of anatomy was excellent in 71.8% (28.75) and 23.75% (9.5) had good anatomical outcome while 3.75% (1.5) had fair results. 40(n=sample size) were included in the study to analyse the articular angles. The mean value of radial inclination was 20.471 standard deviation 1.26, palmar tilt with mean value of 8.725 with standard deviation of 0.678 and radial length with mean of 10.625 with standard deviation of 1.169. The complication observed was 3 pintract infection. All patients achieved full wrist flexion and extension and forearm rotation. Mean time to achieve full wrist. ROM after immobilization was 2 weeks.