bluuebunny/crossref_metadata_2025_split huggingface dataset:
Blepharoplasty Online: Critical Analysis of Content and Patient Comprehensibility
Authors: Kaleeny Joseph , Levine Emma , Okamoto Lauren , McGee Shayan A. , Janis Jeffrey E. 
Published: May 2024

Abstract
Introduction
Patients frequently turn to online information for decision-making factors about aesthetic procedures. The quality of online medical content is an essential supplement to clinical education. These resources assist patients in understanding the risks, benefits, and appropriateness of their desired procedure. This study examines the breadth and readability of online blepharoplasty information, elucidating its educational utility.

Methods
A depersonalized Google search was conducted using the Startpage Search Engine, investigating key phrases, “blepharoplasty decision making factors”, “eye lift decision making factors”, and “eyelid lift decision making factors”. The first three pages of results for each search term, totaling 90 links were screened. Data were extracted for various decision-making factors, subspecialty, gender, and readability.

Results
Twenty-six websites met inclusion for analysis. Thirteen websites were plastic surgery based, five otolaryngology (ENT), five ophthalmology/oculoplastic, one oral-maxillofacial (OMFS), and two mixed-based practices. Most blepharoplasty webpages identified were that of private practice and male surgeons. Half were subspecialties other than plastic surgery. Thirteen common decision-making factors were identified. The most common factors addressed across all texts were recovery followed by cosmetic and functional goals. The least discussed were genetic factors. Average Readability exceeded the 12th grade. There were no significant differences in readability means among subspecialties.

Conclusion
This study examines the online blepharoplasty sphere among US-based practices providing clinical education to patients. No appreciable differences among gender, subspecialty, and readability on decision-making factors were found, highlighting a consistency among surgeons. Most websites fell short of readability standards, however, emphasizing a need for clearer information to patients.

No Level Assigned
This journal requires that authors assign a level of evidence to each submission to which Evidence-Based Medicine rankings are applicable. This excludes Review Articles, Book Reviews, and manuscripts that concern Basic Science, Animal Studies, Cadaver Studies, and Experimental Studies. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266.
Blinatumomab-induced macrophage activating syndrome (MAS) in adult with B-cell acute lymphoblastic leukemia (B-ALL)
Authors: Braun Adam , Otoukesh Salman , Tinajero Jose , Marcucci Guido , Aldoss Ibrahim 
Published: May 2024

AbstractBlinatumomab as a single agent has demonstrated superiority over salvage chemotherapy in patients with relapsed and refractory B-cell acute lymphoblastic leukemia (B-ALL), with manageable safety and efficacy. Though known to have anticipated drug toxicities including cytokine release syndrome (CRS) and neurotoxicity, there is only one prior report of macrophage activating syndrome (MAS) due to blinatumomab. Case Presentation: We report the first case of blinatumomab-induced MAS in an adult. The patient presented with fever, cough, and weakness on the second cycle of blinatumomab. Complete blood count was notable for severe leukopenia, with comprehensive metabolic panel notable for elevated alkaline phosphatase, AST, ALT, LDH, and hyperferritinemia consistent with MAS. The patient was already in MRD-negative remission at presentation with MAS. She responded rapidly to withholding the drug and administration of both tocilizumab and dexamethasone. She was able to restart therapy with blinatumomab dosed at 9 mcg/day with no recurrence of symptoms. Though MAS is not an expected association with blinatumomab, the risk for CRS is. Secondary MAS in this case likely shares a mechanism with other hyperinflammatory conditions. Management includes holding the offending agent, like blinatumomab, and administering tocilizumab and dexamethasone. Future research will be needed to predict which patients are at highest risk to develop MAS after similar T-cell therapies.
PI-QUAL version 2: an update of a standardised scoring system for the assessment of image quality of prostate MRI
Authors: de Rooij Maarten , Allen Clare , Twilt Jasper J. , Thijssen Linda C. P. , Asbach Patrick , Barrett Tristan , Brembilla Giorgio , Emberton Mark , Gupta Rajan T. , Haider Masoom A. , Kasivisvanathan Veeru , Løgager Vibeke , Moore Caroline M. , Padhani Anwar R. , Panebianco Valeria , Puech Philippe , Purysko Andrei S. , Renard-Penna Raphaële , Richenberg Jonathan , Salomon Georg , Sanguedolce Francesco , Schoots Ivo G. , Thöny Harriet C. , Turkbey Baris , Villeirs Geert , Walz Jochen , Barentsz Jelle , Giganti Francesco 
Published: May 2024

Abstract
Multiparametric MRI is the optimal primary investigation when prostate cancer is suspected, and its ability to rule in and rule out clinically significant disease relies on high-quality anatomical and functional images.
Avenues for achieving consistent high-quality acquisitions include meticulous patient preparation, scanner setup, optimised pulse sequences, personnel training, and artificial intelligence systems. The impact of these interventions on the final images needs to be quantified.
The prostate imaging quality (PI-QUAL) scoring system was the first standardised quantification method that demonstrated the potential for clinical benefit by relating image quality to cancer detection ability by MRI.
We present the updated version of PI-QUAL (PI-QUAL v2) which applies to prostate MRI performed with or without intravenous contrast medium using a simplified 3-point scale focused on critical technical and qualitative image parameters.

Clinical relevance statement
High image quality is crucial for prostate MRI, and the updated version of the PI-QUAL score (PI-QUAL v2) aims to address the limitations of version 1. It is now applicable to both multiparametric MRI and MRI without intravenous contrast medium.

Key Points

High-quality images are essential for prostate cancer diagnosis and management using MRI.

PI-QUAL v2 simplifies image assessment and expands its applicability to prostate MRI without contrast medium.

PI-QUAL v2 focuses on critical technical and qualitative image parameters and emphasises T2-WI and DWI.
Few-shot anime pose transfer
Authors: Wang Pengjie , Yang Kang , Yuan Chengzhi , Li Houjie , Tang Wen , Yang Xiaosong 
Published: May 2024

AbstractIn this paper, we propose a few-shot method for pose transfer of anime characters—given a source image of an anime character and a target pose, we transfer the pose of the target to the source character. Despite recent advances in pose transfer on real people images, these methods typically require large numbers of training images of different person under different poses to achieve reasonable results. However, anime character images are expensive to obtain they are created with a lot of artistic authoring. To address this, we propose a meta-learning framework for few-shot pose transfer, which can well generalize to an unseen character given just a few examples of the character. Further, we propose fusion residual blocks to align the features of the source and target so that the appearance of the source character can be well transferred to the target pose. Experiments show that our method outperforms leading pose transfer methods, especially when the source characters are not in the training set.
Quantitative assessment of intervortex anastomosis in central serous chorioretinopathy and fellow eyes: Does the size of anastomotic vessels matter for the diagnosis?
Authors: Demirel Sibel , Ayaz Rabia Eroğlu , Yanık Özge , Batıoğlu Figen , Özmert Emin , Iovino Claudio , Chhablani Jay 
Published: May 2024

Abstract
Purpose
To evaluate the frequency and size of intervortex anastomosis at the posterior pole on en-face spectral domain optical coherence tomography (SD-OCT) images in central serous chorioretinopathy (CSC) cases and their fellow eyes and its associations with choroidal morphology.

Methods
Sixty-five treatment-naive eyes of 65 patients with CSC, 65 fellow eyes, and 55 eyes of healthy age-matched participants were included. The presence of intervortex anastomosis at the watershed zone and asymmetry of the choroidal vessels between the superior and inferior macula were evaluated using 6 × 6 mm en-face SD-OCT. The diameter of the widest Haller vessel and the diameter of the widest anastomotic Haller vessel passing through the watershed zone were measured on en-face SD-OCT images. The choroidal vascularity index (CVI) was assessed using ImageJ software.

Results
Intervortex vein anastomosis on the horizontal watershed zone was detected in 75.4% diseased eyes, 61.5% in fellow eyes, and 36.4% in healthy age-matched controls (p < 0.001). The mean CVI was significantly higher in both diseased (74.3 ± 2.3%) and fellow (73.8 ± 2.2%) eyes of CSC cases than in healthy controls (72.5 ± 2.3%) (p = 0.002, p = 0.013, respectively). In the cases with intervortex vein anastomosis, the diameter of the widest anastomotic Haller vessel passing through the watershed zone was 0.40 ± 0.10 mm in diseased eyes, 0.35 ± 0.11 mm in fellow eyes, and 0.30 ± 0.09 mm in healthy age-matched controls (p = 0.001).

Conclusions
Intervortex anastomosis might be seen as a variation in normal eyes, however, its frequency and the size of anastomotic vessels are significant higher in not only CSC but also in fellow eyes.
BECN1 mRNA expression in breast cancer tissue; significant correlation to tumor grade
Authors: Aglan Sarah Ahmed , Awad Ahmed Mostafa , Elwany Yasmine Nagy , Shawky Sanaa , Salam Radwa Mohamed Abdel , Omar Rasha Said , Ghazala Rasha Abdel Mawla , Soliman Nada Ahmed , Khedr Marwa Ibrahim , Kandil Lamia Said , Sultan Mohamed , Hamed Yasser , Kandil Noha Said 
Published: May 2024

AbstractBreast cancer (BC) is a heterogenous disease with multiple pathways implicated in its development, progression, and drug resistance. Autophagy, a cellular process responsible for self-digestion of damaged organelles, had been recognized as eminent player in cancer progression and chemotherapeutic resistance. The haploinsufficiency of Beclin 1 (BECN1), autophagy protein, is believed to contribute to cancer pathogenesis and progression. In our study, we investigated the expression of BECN1 in a BC female Egyptian patient cohort, as well as its prognostic role through evaluating its association with disease free survival (DFS) after 2 years follow up and association of tumor clinicopathological features. Twenty frozen female BC tissue samples and 17 adjacent normal tissue were included and examined for the expression levels of BECN1. Although the tumor tissues showed lower expression 0.73 (0–8.95) than their corresponding normal tissues 1.02 (0.04–19.59), it was not statistically significant, p: 0.463. BECN1 expression was not associated with stage, nodal metastasis or tumor size, p:0.435, 0.541, 0.296, respectively. However, statistically significant negative correlation was found between grade and BECN1 mRNA expression in the studied cases, p:0.028. BECN1 expression had no statistically significant association with DFS, P = 0.944. However, we observed that triple negative (TNBC) cases had significantly lower DFS rate than luminal BC patients, p: 0.022, with mean DFS 19.0 months, while luminal BC patients had mean DFS of 23.41 months. Our study highlights the potential role of BECN1 in BC pathogenesis, showing that BECN1 expression correlates with poorer differentiation of BC, indicating its probable link with disease aggressiveness. DFS two years follow up showed that TNBC subtype remains associated with less favorable prognosis.
Advances in long-read single-cell transcriptomics
Authors: Kumari Pallawi , Kaur Manmeet , Dindhoria Kiran , Ashford Bruce , Amarasinghe Shanika L. , Thind Amarinder Singh 
Published: May 2024

AbstractLong-read single-cell transcriptomics (scRNA-Seq) is revolutionizing the way we profile heterogeneity in disease. Traditional short-read scRNA-Seq methods are limited in their ability to provide complete transcript coverage, resolve isoforms, and identify novel transcripts. The scRNA-Seq protocols developed for long-read sequencing platforms overcome these limitations by enabling the characterization of full-length transcripts. Long-read scRNA-Seq techniques initially suffered from comparatively poor accuracy compared to short read scRNA-Seq. However, with improvements in accuracy, accessibility, and cost efficiency, long-reads are gaining popularity in the field of scRNA-Seq. This review details the advances in long-read scRNA-Seq, with an emphasis on library preparation protocols and downstream bioinformatics analysis tools.
The detection of a strong episignature for Chung–Jansen syndrome, partially overlapping with Börjeson–Forssman–Lehmann and White–Kernohan syndromes
Authors: Vos Niels , Haghshenas Sadegheh , van der Laan Liselot , Russel Perle K. M. , Rooney Kathleen , Levy Michael A. , Relator Raissa , Kerkhof Jennifer , McConkey Haley , Maas Saskia M. , Vissers Lisenka E. L. M. , de Vries Bert B. A. , Pfundt Rolph , Elting Mariet W. , van Hagen Johanna M. , Verbeek Nienke E. , Jongmans Marjolijn C. J. , Lakeman Phillis , Rumping Lynne , Bosch Danielle G. M. , Vitobello Antonio , Thauvin-Robinet Christel , Faivre Laurence , Nambot Sophie , Garde Aurore , Willems Marjolaine , Genevieve David , Nicolas Gaël , Busa Tiffany , Toutain Annick , Gérard Marion , Bizaoui Varoona , Isidor Bertrand , Merla Giuseppe , Accadia Maria , Schwartz Charles E. , Ounap Katrin , Hoffer Mariëtte J. V. , Nezarati Marjan M. , van den Boogaard Marie-José H. , Tedder Matthew L. , Rogers Curtis , Brusco Alfredo , Ferrero Giovanni B. , Spodenkiewicz Marta , Sidlow Richard , Mussa Alessandro , Trajkova Slavica , McCann Emma , Mroczkowski Henry J. , Jansen Sandra , Donker-Kaat Laura , Duijkers Floor A. M. , Stuurman Kyra E. , Mannens Marcel M. A. M. , Alders Mariëlle , Henneman Peter , White Susan M. , Sadikovic Bekim , van Haelst Mieke M. 
Published: May 2024

AbstractChung-Jansen syndrome is a neurodevelopmental disorder characterized by intellectual disability, behavioral problems, obesity and dysmorphic features. It is caused by pathogenic variants in the PHIP gene that encodes for the Pleckstrin homology domain-interacting protein, which is part of an epigenetic modifier protein complex. Therefore, we hypothesized that PHIP haploinsufficiency may impact genome-wide DNA methylation (DNAm). We assessed the DNAm profiles of affected individuals with pathogenic and likely pathogenic PHIP variants with Infinium Methylation EPIC arrays and report a specific and sensitive DNAm episignature biomarker for Chung–Jansen syndrome. In addition, we observed similarities between the methylation profile of Chung–Jansen syndrome and that of functionally related and clinically partially overlapping genetic disorders, White–Kernohan syndrome (caused by variants in DDB1 gene) and Börjeson–Forssman–Lehmann syndrome (caused by variants in PHF6 gene). Based on these observations we also proceeded to develop a common episignature biomarker for these disorders. These newly defined episignatures can be used as part of a multiclass episignature classifier for screening of affected individuals with rare disorders and interpretation of genetic variants of unknown clinical significance, and provide further insights into the common molecular pathophysiology of the clinically-related Chung–Jansen, Börjeson–Forssman–Lehmann and White–Kernohan syndromes.
The 23–24 March 2021 lava fountain at Mt Etna, Italy
Authors: Andronico Daniele , D’Oriano Claudia , Pardini Federica , La Spina Alessandro , Vitturi Mattia de’ Michieli , Bonfanti Pietro , Cristaldi Antonino , Ferrari Ferruccio 
Published: May 2024

AbstractIn 2021, more than 50 paroxysmal episodes occurred at the South-East Crater (SEC) of Mt Etna, Italy. The 23–24 March lava fountain was one of the longest episodes and began with weak Strombolian explosions, gradually transitioning to lava fountaining. The eruption intensity then dropped more slowly than in previous episodes, resulting in pulsating Strombolian explosions dominated by ash emission. Thirty-four tephra samples were used to reconstruct the fallout dispersal and estimate the total erupted mass. Grain size, textural, petrological and geochemical analyses indicate different features and were compared with the gas phase (SO2 and HCl) in the volcanic plume. By applying stochastic global optimization to simulations of the temporal evolution of the eruption column height and tephra dispersal and deposition, the total erupted mass retrieved (6.76 × 108 kg) matches well the total erupted mass estimation by the ground-based deposit (8.03 ± 2.38 × 108 kg), reducing the column height throughout the episode from 6.44 to 4.5 km above sea level and resulting in a mass eruption rate ranging from 1.96 × 105 to 8.18 × 103 kg/s. The unusual duration of the March episode and the characteristics of the erupted products point to the change in explosive style and magma fragmentation from fountaining to ash emission phases, associated with a slower magma supply inducing a change in magma rheology and a final, prolonged ash generation. Furthermore, this study showed that using observational data and the variation in eruption source parameters for numerical simulations can improve the accuracy of predicting the dispersal plume, thus mitigating the potential impact of longer paroxysmal episodes.
Pseudoscalar Mesons and Emergent Mass
Authors: Raya Khépani , Bashir Adnan , Binosi Daniele , Roberts Craig D. , Rodríguez-Quintero José 
Published: May 2024

AbstractDespite its role in the continuing evolution of the Universe, only a small fraction of the mass of visible material can be attributed to the Higgs boson alone. The overwhelmingly dominant share may/should arise from the strong interactions that act in the heart of nuclear matter; namely, those described by quantum chromodynamics. This contribution describes how studying and explaining the attributes of pseudoscalar mesons can open an insightful window onto understanding the origin of mass in the Standard Model and how these insights inform our knowledge of hadron structure. The survey ranges over distribution amplitudes and functions, electromagnetic and gravitational form factors, light-front wave functions, and generalized parton distributions. Advances made using continuum Schwinger function methods and their relevance for experimental efforts are highlighted.
Evolution of Crack Source Mechanisms in Laboratory Hydraulic Fracturing on Harcourt Granite
Authors: Zhang Xin , Si Guangyao , Oh Joung , Zhao Guozhen 
Published: May 2024

AbstractHydraulic fracturing has gained escalating significance in recovering unconventional reservoirs. However, the failure mechanism and its evolution with progressive fluid injection are not fully understood for granitic materials. To investigate, triaxial hydraulic fracturing on Harcourt granite and acoustic emission (AE) monitoring was performed by the self-developed multi-physical rock testing platform (MRTP). Source mechanism analysis suggests that tensile cracks account for the majority (62%) of all cracks throughout the hydraulic fracturing process. Tensile cracks with large energy are induced mainly around the borehole bottom, but their average energy is smaller than shear cracks. The entire hydraulic fracturing process is divided into three stages by injection measurements. In Stage 1, AE events are recorded with low energy emissions but high signal-to-noise ratios, revealing the initiation of hydraulic fractures before peak injection pressure. Tensile cracks are more dominant (78%) than other stages. In Stage 2, the number and magnitude of AE events increase exponentially along the trace formed in Stage 1. In Stage 3, hydraulic fractures have the largest magnitude among all stages. Shear cracks are nearly the same proportion as Stage 2, but more shear cracks with large magnitudes are observed following the trace formed by tensile cracks. A dense population of shear cracks can be found at the borehole bottom, and their distribution follows the average slip plunge of individual shear cracks induced by the injection fluid.
Beauville p-groups of wild type and groups of maximal class
Authors: Fernández-Alcober Gustavo A. , Gavioli Norberto , Gül Şükran , Scoppola Carlo M. 
Published: May 2024

AbstractLet G be a Beauville p-group. If G exhibits a ‘good behaviour’ with respect to taking powers, then every lift of a Beauville structure of $$G/\Phi (G)$$

G
/
Φ
(
G
)

is a Beauville structure of G. We say that G is a Beauville p-group of wild type if this lifting property fails to hold. Our goal in this paper is twofold: firstly, we fully determine the Beauville groups within two large families of p-groups of maximal class, namely metabelian groups and groups with a maximal subgroup of class at most 2; secondly, as a consequence of the previous result, we obtain infinitely many Beauville p-groups of wild type.
Surface optimization of trapezoidal thread spindles—tribological analysis and application
Authors: Denkena Berend , Bergmann Benjamin , Wege Christian , von Soden Moritz , Gereke-Bornemann Hans 
Published: May 2024

AbstractTrapezoidal threaded spindles are ideal for supporting heavy loads and are therefore frequently used in heavy-duty lifting systems. Both the forming thread rolling process and the machining thread whirling process can be used to manufacture these lead screws. In order to improve the low efficiency of trapezoidal screw drives, it is crucial to understand and minimize friction losses. As part of a cooperation project between the Institute of Production Engineering and Machine Tools (IFW) and Bornemann Gewindetechnik, research was carried out into adapting the whirling process to optimize the tribological properties of threaded spindles. The process developed makes it possible to reduce the coefficient of friction in trapezoidal screw drives and thus also the required torque. By using whirled microtextures, the friction loss can be reduced by 25.5% and adhesive wear can be significantly reduced.