bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pelatihan Pembuatan Briket dengan Bahan Limbah Tempurung Kelapa pada Kelompok Masyarakat Desa Balobone Kecamatan Mawasangka Kabupaten Buton Tengah
Authors: Mubarak Azhar Aras , Samaluddin Samaluddin , Yuvita Satriani Djuli  , Rahmawati Djunuda  , Alfiah Alif  , Alfonds Andrew Maramis  , Anatje Lihiang  , Moh Fikri Pomalingo  
Published: May 2024

Salah satu program unggulan kegiatan Kosabangsa (Kegiatan Sosial Membangun Masyarakat) Tim Kolaborasi USN Kolaka dengan UNIMA Manado untuk pelaksanaan tahun 2023 adalah memberikan pelatihan kepada masyarakat Desa Balobone Kecamatan Mawasangka Kabupaten Buton Tengah tentang pengolahan tempurung kelapa menjadi briket yang digunakan sebagai bahan bakar alternatif dalam kehidupan sehari-hari khususnya dalam memanggang makanan yang bisa menjadi nilai jual jika dibuat dengan baik. Potensi kelapa yang besar di lingkungan desa menjadi faktor utama dalam mengolah tempurung kelapa yang selama ini sebagian besar hanya dibuang atau dibakar langsung. Dengan ditunjang dengan pengadaan mesin TTG pengolah tempurung kelapa menjadi briket maka diharapkan produksi briket di desa memanfaatkan potensi perkebunan dapat berjalan maksimal. Metode yang diterapkan pada kegiatan ini adalah penyampaian materi pembuatan briket, kemudian dilanjutkan dengan praktik langsung pengolahan tempurung kelapa menjadi briket dengan melalui proses persiapan, penghancuran tempurung, pencampuran, pencetakan pada mesin dan pengeringan. Kegiatan ini menarik antusias yang besar dari masyarakat sekitar sehingga kedepan masyarakat mampu mengolah sendiri limbah tempurung kelapa yang tidak terpakai. Tujuan akhir yang ingin dicapai adalah meningkatan pemahaman dan keterampilan masyarakat sekitar dalam pengolahan tempurung kelapa menjadi briket siap pakai.
STUDI ETNOBOTANI TUMBUHAN OBAT DALAM MASYARAKAT ADAT TIGO LUHAH TANAH SEKUDUNG SIULAK KABUPATEN KERINCI
Authors: Santosa Tomi Apra , Arsih Fitri , Lufri . , Festiyed . , Ilwandri . , Suhaimi . 
Published: May 2024

Tigo luhah tanah sekudung is an indigenous area located in the Siulak area of Kerinci Regency. The indigenous people of Tigo Luhah Tanah Sekudung have knowledge in traditional medicine. In addition, along with the development of modern medicine, the traditional medicine tradition of Tgo Luhah Tanah Sekudung indigenous people has not been inventoried. The purpose of this study was to determine the type of medicinal plants in the indigenous people of tigo luhah tanah sekudung Siulak, Kerinci Regency. Research type of exploratory descriptive research. The research was conducted in Mukai Hilir Village, Siulak Mukai District. Data collection techniques through observation, survey, questionnaire and interview. Community knowledge through questionnaires. The number of respondents in the study was 15 people. The technique of ensuring data validity is Triangulation. Data analysis is descriptive qualitative analysis. The results showed that there are 45 species and 35 families used by the indigenous people of Tigo Luhah Tanah Sekudung Siulak Kerinci Regency.
SISTEM INFORMASI INVENTORY BERBASIS WEB MENGGUNAKAN METODE OOAD PADA PT BGA
Authors: Deddy Deddy , Arnomo Sasa Ani 
Published: May 2024

Perkembangan pesat dalam bidang komunikasi telah memicu minat masyarakat untuk beralih ke teknologi informasi dan komunikasi. Penggunaan teknologi informasi oleh perusahaan memainkan peran penting dalam mempermudah dan mempercepat pengelolaan bisnis mereka. Salah satu bagian penting dalam perusahaan adalah bagian persediaan (inventory), yang memiliki peran kunci dalam mengelola stok barang perusahaan tersebut. Sistem pengelolaan inventory sangat berdampak pada kinerja suatu perusahaan. PT Bestbuild Globalindo Aluminium merupakan salah satu perusahaan yang bergerak di bidang manufaktur pabrikasi kusen, pintu dan jendela aluminium. Seiring dengan berkembangnya perusahaan dan bertambahnya jumlah barang inventory, muncul permasalahan yang menuntut perhatian yakni kesulitan dalam memperoleh informasi yang cepat, tepat, dan akurat mengenai barang inventory yang ada. Dari permasalahan tersebut maka diperlukan perancangan dan pembangunan sistem informasi inventory barang yang lebih terstruktur dan efisien. Tujuan penelitian ini adalah untuk merancang dan membangun sebuah sistem informasi inventory barang yang diharapkan dapat meningkatkan efisiensi pengelolaan inventory, dan menyediakan informasi yang lebih akurat dan dapat diandalkan. Metode penelitian yang digunakan oleh peneliti adalah OOAD (Object Oriented Analysis Design) dengan pemodelan menggunakan UML. Hasil penelitian yang dilakukan oleh peneliti menunjukkan bahwa sistem informasi inventory ini dirancang dan dibangun dengan menggunakan bahasa pemrograman PHP dan penyimpanan data melalui database MySQL. Sistem informasi inventory yang dibangun dapat memberikan laporan yang terkini kepada pimpinan perusahaan mengenai barang-barang inventory di PT Bestbuild Globalindo Aluminium.
Analisis Digital Forensik Recovery Data pada Flashdisk Menggunakan Metode National Institute Of Justice (NIJ)
Authors: Huda Syaiful , Novrianda Dasmen Rahmat , Ardiansyah Ardiansyah , Pranata Viren , Januarta Ari 
Published: May 2024

Investigasi penerapan teknik komputer forensik dalam proses pengembalian data dengan memanfaatkan salah satu alat yaitu disk test Dalam konteks ini, fokus diberikan pada analisis kinerja dan efektivitas alat forensik yang digunakan untuk mengembalikan data dari media penyimpanan digital, terutama pada tahap disk test l. Dalam forensik IT dapat ditemukan bukti-bukti seperti dokumen, informasi keuangan, e-mail, log, video, transkripsi pesan suara dan lain-lain seperti Terutama pada dokumen atau data yang sengaja diambil atau dihapus datanya dari perangkat USB dan harus dipulihkan data yang telah hilang Pada tahap awal penelitian penulis akan mengumpulkan data tentang alat yang digunakan dan oleh karena itu, Penulis menganggap bahwa diperlukan tools yang dapat menganalisis tools mana yang lebih baik dan efisien dalam menangani salah satu permasalahan tersebut. Tools yang akan digunakan adalah Teskdisk. Hasil penelitian ini memberikan wawasan mendalam tentang efektivitas alat disk tesk dalam konteks pemulihan data melalui pendekatan forensik komputer. Implikasi dari temuan penelitian ini dapat mendukung pengembangan praktik terbaik dalam menghadapi tantangan dan kompleksitas pengembalian data di dunia digital yang berkembang.
The management of heart failure in Sweden—the physician’s perspective: a survey
Authors: Ferrannini Giulia , Biber Mattia Emanuele , Abdi Sam , Ståhlberg Marcus , Lund Lars H. , Savarese Gianluigi 
Published: May 2024

AimsTo assess the barriers to guideline-directed medical therapy (GDMT) use in heart failure (HF), diagnostic workup and general knowledge about HF among physicians in Sweden.MethodsA survey about the management of HF was sent to 828 Swedish physicians including general practitioners (GPs) and specialists during 2021–2022. Answers were reported as percentages and comparisons were made by specialty (GPs vs. specialists).ResultsOne hundred sixty-eight physicians participated in the survey (40% females, median age 43 years; 41% GPs and 59% specialists). Electrocardiography and New York Heart Association class evaluations are mostly performed once a year by GPs (46%) and at every outpatient visit by specialists (40%). Echocardiography is mostly requested if there is clinical deterioration (60%). One-third of participants screen for iron deficiency only if there is anemia. Major obstacles to implementation of different drug classes in HF with reduced ejection fraction are related to side effects, with no significant differences between specialties. Device implantation is deemed appropriate regardless of aetiology (69%) and patient age (86%). Specialists answered correctly to knowledge questions more often than GPs. Eighty-six percent of participants think that GDMT should be implemented as much as possible. Most participants (57%) believe that regular patient assessment in nurse-led HF clinics improve adherence to GDMT.ConclusionObstacles to GDMT implementation according to physicians in Sweden mainly relate to potential side effects, lack of specialist knowledge and organizational aspects. Further efforts should be placed in educational activities and structuring of nurse-led clinics.
Ex vivo expansion in a clinical grade medium, containing growth factors from human platelets, enhances migration capacity of adipose stem cells
Authors: Agostini Francesco , Vicinanza Carla , Lombardi Elisabetta , Da Ros Francesco , Marangon Miriam , Massarut Samuele , Mazzucato Mario , Durante Cristina 
Published: May 2024

IntroductionAdipose tissue mesenchymal stem/stromal cells (ASC) can be used as advanced therapy medicinal product in regenerative and cancer medicine. We previously demonstrated Supernatant Rich in Growth Factors (SRGF) can replace fetal bovine serum (FBS) to expand ASC by a clinical grade compliant protocol. The therapeutic potential of ASC is based also on their homing capacity toward inflammatory/cancer sites: oriented cell migration is a fundamental process in this scenario. We investigated the impact of SRGF on ASC migration properties.MethodsThe motility/migration potential of ASC expanded in 5% SRGF was analyzed, in comparison to 10% FBS, by standard wound healing, bidimensional chemotaxis and transwell assays, and by millifluidic transwell tests. Mechanisms involved in the migration process were investigated by transient protein overexpression.ResultsIn comparison to standard 10% FBS, supplementation of the cell culture medium with 5% SRGF, strongly increased migration properties of ASC along the chemotactic gradient and toward cancer cell derived soluble factors, both in static and millifluidic conditions. We showed that, independently from applied migratory stimulus, SRGF expanded ASC were characterized by far lower expression of α-smooth muscle actin (αSMA), a protein involved in the cell migration machinery. Overexpression of αSMA induced a significant and marked decrease in migration capacity of SRGF expanded ASC.DiscussionIn conclusion, 5% SRGF addition in the cell culture medium increases the migration potential of ASC, reasonably through appropriate downregulation of αSMA. Thus, SRGF could potentially improve the therapeutic impact of ASC, both as modulators of the immune microenviroment or as targeted drug delivery vehicles in oncology.
Cross-modality transfer learning with knowledge infusion for diabetic retinopathy grading
Authors: Chen Tao , Bai Yanmiao , Mao Haiting , Liu Shouyue , Xu Keyi , Xiong Zhouwei , Ma Shaodong , Yang Fang , Zhao Yitian 
Published: May 2024

BackgroundUltra-wide-field (UWF) fundus photography represents an emerging retinal imaging technique offering a broader field of view, thus enhancing its utility in screening and diagnosing various eye diseases, notably diabetic retinopathy (DR). However, the application of computer-aided diagnosis for DR using UWF images confronts two major challenges. The first challenge arises from the limited availability of labeled UWF data, making it daunting to train diagnostic models due to the high cost associated with manual annotation of medical images. Secondly, existing models' performance requires enhancement due to the absence of prior knowledge to guide the learning process.PurposeBy leveraging extensively annotated datasets within the field, which encompass large-scale, high-quality color fundus image datasets annotated at either image-level or pixel-level, our objective is to transfer knowledge from these datasets to our target domain through unsupervised domain adaptation.MethodsOur approach presents a robust model for assessing the severity of diabetic retinopathy (DR) by leveraging unsupervised lesion-aware domain adaptation in ultra-wide-field (UWF) images. Furthermore, to harness the wealth of detailed annotations in publicly available color fundus image datasets, we integrate an adversarial lesion map generator. This generator supplements the grading model by incorporating auxiliary lesion information, drawing inspiration from the clinical methodology of evaluating DR severity by identifying and quantifying associated lesions.ResultsWe conducted both quantitative and qualitative evaluations of our proposed method. In particular, among the six representative DR grading methods, our approach achieved an accuracy (ACC) of 68.18% and a precision (pre) of 67.43%. Additionally, we conducted extensive experiments in ablation studies to validate the effectiveness of each component of our proposed method.ConclusionIn conclusion, our method not only improves the accuracy of DR grading, but also enhances the interpretability of the results, providing clinicians with a reliable DR grading scheme.
The potential protective role of Parkinson’s disease against hypothyroidism: co-localisation and bidirectional Mendelian randomization study
Authors: Lei Jiang , He Wenxuan , Liu Yao , Zhang Qinxin , Liu Yingyao , Ou Qican , Wu Xianli , Li Fenglin , Liao Jiajia , Xiao Yousheng 
Published: May 2024

BackgroundThe association between hypothyroidism and Parkinson’s disease (PD) has sparked intense debate in the medical community due to conflicting study results. A better understanding of this association is crucial because of its potential implications for both pathogenesis and treatment strategies.MethodsTo elucidate this complex relationship, we used Bayesian co-localisation (COLOC) and bidirectional Mendelian randomization (MR) analysis. COLOC was first used to determine whether hypothyroidism and PD share a common genetic basis. Subsequently, genetic variants served as instrumental variables in a bidirectional MR to explore causal interactions between these conditions.ResultsCOLOC analysis revealed no shared genetic variants between hypothyroidism and PD, with a posteriori probability of hypothesis 4 (PPH4) = 0.025. Furthermore, MR analysis indicated that hypothyroidism does not have a substantial causal effect on PD (OR = 0.990, 95% CI = 0.925, 1.060, p = 0.774). Conversely, PD appears to have a negative causal effect on hypothyroidism (OR = 0.776, 95% CI = 0.649, 0.928, p = 0.005).ConclusionOur findings suggest the absence of shared genetic variants between hypothyroidism and PD. Interestingly, PD may inversely influence the risk of developing hypothyroidism, a finding that may inform future research and clinical approaches.
The effect of multimorbidity patterns on physical and cognitive function in diabetes patients: a longitudinal cohort of middle-aged and older adults in China
Authors: Zhou Xieting , Qin Juan-Juan , Li Hang , Chen Jiyu , Zhang Qing , Ye Xujun 
Published: May 2024

BackgroundThe prevalence of diabetes has increased rapidly, and comorbid chronic conditions are common among diabetes patients. However, little is known about the pattern of multimorbidity in diabetes patients and the effect on physical and cognitive function. This study aimed to assess the disease clusters and patterns of multimorbidity in diabetes patients using a novel latent class analysis (LCA) approach in middle-aged and older adults and explore the association between different clusters of multimorbidity in diabetes and the effect on physical and cognitive function.MethodsThis national observational study included 1,985 diabetes patients from the four waves of the China Health and Retirement Longitudinal Study (CHARLS) in 2011 to 2018. Thirteen chronic diseases were used in latent class analysis to identify the patterns of multimorbidity in diabetes, which span the cardiovascular, physical, psychological, and metabolic systems. Cognitive function is assessed via a structured questionnaire in three domains: memory, executive function, and orientation. We combined activities of daily living (ADL) with instrumental activities of daily living (IADL) to measure physical function. Linear mixed models and negative binomial regression models were used to analyze the association between patterns of multimorbidity in diabetes and the effect on cognitive function and disability, respectively.ResultsA sample of 1,985 diabetic patients was identified, of which 1,889 (95.2%) had multimorbidity; their average age was 60.6 years (standard deviation (SD) = 9.5), and 53.1% were women. Three clusters were identified: “cardio-metabolic” (n = 972, 51.5%), “mental-dyslipidemia-arthritis” (n = 584, 30.9%), and “multisystem morbidity” (n = 333, 17.6%). Compared with diabetes alone, the “multisystem morbidity” class had an increased association with global cognitive decline. All patterns of multimorbidity were associated with an increased risk of memory decline and disability; however, the “multisystem morbidity” group also had the strongest association and presented a higher ADL-IADL disability (ratio = 4.22, 95% CI = 2.52, 7.08) and decline in memory Z scores (β = −0.322, 95% CI = −0.550, −0.095, p = 0.0058).ConclusionSignificant longitudinal associations between different patterns of multimorbidity in diabetes patients and memory decline and disability were observed in this study. Future studies are needed to understand the underlying mechanisms and common risk factors for multimorbidity in diabetes patients and to propose treatments that are more effective.
The mediating role of self-control on the relations between adverse childhood experiences and substance use among adolescents in Uganda
Authors: Namusoke Jane , Amone-P’Olak Kennedy , Nakanwagi Carol Chosen , Kibedi Henry , Mayengo Nathaniel , Ssenyonga Joseph , Omech Bernard 
Published: May 2024

ObjectiveAdverse childhood experiences (ACEs) are established risk factors for undesirable consequences in adolescence and early adulthood, including substance use and a lack of self-control. Based on the Social Bonds Theory (SBT), this study aims to expand our knowledge of the pathways from ACEs and self-control to substance use in adolescence and early adulthood.MethodsThe extent to which self-control mediates the association between ACEs and substance use was examined in a cross-sectional survey of 358 adolescents and young adults (N = 234, 65.5% girls, mean age 17.7, SD 0.58, range 15–18). Data were gathered using the Adverse Childhood Experiences (ACE-10) questionnaire, the Drug Abuse Screening Test (DAST-10), and the 10-item self-control scale to assess childhood adversity, substance use, and self-control, respectively.ResultsACEs were widely reported and significantly associated with substance use and a lack of self-control. Self-control strongly predicted substance use, independent of ACEs. Among those reporting no ACEs, one to two, three to four, and five or more, there were significant variations in the respondents’ substance use (F(3, 400) = 12.69, p = 0.001). Self-control explained 51.2% (95% confidence interval [CI]: 41, 61%) of the associations between ACEs and substance use as assessed by linear regression.ConclusionSelf-control is key to understanding why adolescents and young adults with a history of childhood adversity indulge in substance use. Therefore, there is a need to advocate for psychological interventions such as cognitive and behavioural therapy that have demonstrated efficacy in promoting self-control in adolescents and young adults.
Quality of life among caregivers of patients with severe mental illness in northwest Ethiopia, 2022: an institutional-based cross-sectional study
Authors: Munie Birhanu Mengist , Guangul Melak Menberu , Mamaru Almaz , Asnakew Sintayehu , Amha Haile , Tedla Assasahegn 
Published: May 2024

BackgroundSevere mental illness has negative consequences not only for the person suffering from it but also for their caregiver’s quality of life and the community in which they reside. These impacts could be particularly visible in low- and middle-income countries, where the treatment gap for mental illnesses is particularly high. There is a dearth of evidence in Ethiopia.ObjectiveThis study aims to assess the quality of life and its associated factors among caregivers of patients with severe mental illness at Felege Hiwot and Tibebe Ghion Compressive Specialized Hospital, Bahir Dar, Northwest Ethiopia, in 2022.MethodsAn institution-based cross-sectional study design was conducted at Felege Hiwot and Tibebe Ghion Compressive Specialized Hospitals from 13 June to 13 July 2022. A systematic random sample technique was utilized to select 469 study participants. The World Health Organization quality of life-BREF questionnaire was utilized to assess quality of life, and perceived stigma was measured through a family interview schedule questionnaire. The data were gathered using the epicollect5 software with a face-to-face interview method and then exported to SPSS-25. Simple and multiple linear regression analyses were conducted to identify associated factors of quality of life for variables that are statistically significant (p-value&lt; 0.05) with B-coefficients and a 95% CI. Descriptive statistics were used to describe the outcome and predictor variables.ResultsA total of 456 respondents participated, with a response rate of 97.2%. The result showed that the mean quality-of-life score of caregivers of patients with severe mental illness for each domain (mean ± standard deviations) was between 46.5 ± 18.7 and 51.2 ± 19.9, with the worst score of zero in the environmental domain and 94 in the social domain. In multiple regression, living in a rural area (B = −5.2; 95% CI, −8.9, −1.8), being illiterate (B = −7.2; 95% CI, −10.6, −3.7), having chronic medical illness (B = −5.2; 95% CI, −8.6, −1.7), having probable cases of anxiety (B = −6.9, 95% CI, −10.5, −13.3), having probable cases of depression (B = −4.9; 95% CI, −8.2, −1.7), and the presence of perceived stigma (B = −7.9; 95% CI, −11.2, −4.77) were significantly associated with the overall quality of life. This analysis suggests that the identified factors can predict over 40% of the variability in overall quality of life scores for caregivers.ConclusionThe quality of life of caregivers of patients with severe mental illness was found to be low. Living in a rural area, being illiterate, having chronic medical illnesses, having probable cases of anxiety and depression, and being stigmatized were negatively associated with the overall quality of life. The findings indicate the necessity for health professionals, the government, and other concerned bodies to pay more attention to caregivers’ quality of life.
Streptococcus suis meningitis in China: a case report
Authors: Liu Tiantian , Liu Hengfang , Jia Yanjie 
Published: May 2024

IntroductionStreptococcus suis is one of the porcine pathogens that have recently emerged as a pathogen capable of causing zoonoses in some humans. Patients infected with S. suis can present with sepsis, meningitis, or arthritis. Compared to common pathogens, such as Meningococcus, Streptococcus pneumoniae, and Haemophilus influenzae, S. suis infections in humans have been reported only rarely.MethodsThis case report described a 57-year-old man who presented with impaired consciousness and fever following several days of backache. He was a butcher who worked in an abattoir and had wounded his hands 2 weeks prior. The patient was dependent on alcohol for almost 40 years. S. suis was detected in the cerebrospinal fluid by metagenomic next-generation sequencing. Although he received adequate meropenem and low-dose steroid therapy, the patient suffered from bilateral sudden deafness after 5 days of the infection. The final diagnosis was S. suis meningitis and sepsis.ResultsThe patient survived with hearing loss in both ears and dizziness at the 60-day follow-up.DiscussionWe reported a case of S. suis infection manifested as purulent meningitis and sepsis. Based on literature published worldwide, human S. suis meningitis shows an acute onset and rapid progression in the nervous system. Similar to bacterial meningitis, effective antibiotics, and low-dose steroids play important roles in the treatment of human S. suis meningitis.