bluuebunny/crossref_metadata_2025_split huggingface dataset:
The research history of the Middle Triassic fishes of Monte San Giorgio: getting out of the shadow of aquatic reptiles
Authors: Bürgin Toni 
Published: April 2024

AbstractAround the middle of the nineteenth century, Italian palaeontologists began to investigate fossils of fishes and reptiles from the Middle Triassic outcrops in the vicinity of Monte San Giorgio (Canton Ticino, Switzerland). In 1924, researchers from the University of Zurich started their scientific excavations on the Swiss side. The many fish fossils found since then have often stood in the shadow of the more spectacular and mostly larger fossils of various aquatic reptiles. Beginning around 1980 the fish fossils in the collection of the Palaeontological Institute and Museum of Zurich University have subsequently been brought out of this shadow. The picture presently emerging is that of a species rich fish fauna located in six different fossiliferous beds of Anisian and Ladinian age with a few chondrichthyan, some coelacanth and a wealth of different actinopterygian taxa, many of them well preserved. The ongoing work not only results in taxonomic and systematic novelties, but gives also new insights into their palaeobiology, palaeoecology and palaeobiogeography.
Reconstruction the feedback regulation of amino acid metabolism to develop a non-auxotrophic l-threonine producing Corynebacterium glutamicum
Authors: Liu Jianhang , Liu Jiao , Li Jiajun , Zhao Xiaojia , Sun Guannan , Qiao Qianqian , Shi Tuo , Che Bin , Chen Jiuzhou , Zhuang Qianqian , Wang Yu , Sun Jibin , Zhu Deqiang , Zheng Ping 
Published: April 2024

Abstractl-Threonine is an important feed additive with the third largest market size among the amino acids produced by microbial fermentation. The GRAS (generally regarded as safe) industrial workhorse Corynebacterium glutamicum is an attractive chassis for l-threonine production. However, the present l-threonine production in C. glutamicum cannot meet the requirement of industrialization due to the relatively low production level of l-threonine and the accumulation of large amounts of by-products (such as l-lysine, l-isoleucine, and glycine). Herein, to enhance the l-threonine biosynthesis in C. glutamicum, releasing the aspartate kinase (LysC) and homoserine dehydrogenase (Hom) from feedback inhibition by l-lysine and l-threonine, respectively, and overexpressing four flux-control genes were performed. Next, to reduce the formation of by-products l-lysine and l-isoleucine without the cause of an auxotrophic phenotype, the feedback regulation of dihydrodipicolinate synthase (DapA) and threonine dehydratase (IlvA) was strengthened by replacing the native enzymes with heterologous analogues with more sensitive feedback inhibition by l-lysine and l-isoleucine, respectively. The resulting strain maintained the capability of synthesizing enough amounts of l-lysine and l-isoleucine for cell biomass formation but exhibited almost no extracellular accumulation of these two amino acids. To further enhance l-threonine production and reduce the by-product glycine, l-threonine exporter and homoserine kinase were overexpressed. Finally, the rationally engineered non-auxotrophic strain ZcglT9 produced 67.63 g/L (17.2% higher) l-threonine with a productivity of 1.20 g/L/h (108.0% higher) in fed-batch fermentation, along with significantly reduced by-product accumulation, representing the record for l-threonine production in C. glutamicum. In this study, we developed a strategy of reconstructing the feedback regulation of amino acid metabolism and successfully applied this strategy to de novo construct a non-auxotrophic l-threonine producing C. glutamicum. The main end by-products including l-lysine, l-isoleucine, and glycine were almost eliminated in fed-batch fermentation of the engineered C. glutamicum strain. This strategy can also be used for engineering producing strains for other amino acids and derivatives.
In-hospital mortality of patients with periprosthetic joint infection
Authors: Reinhard Jan , Lang Siegmund , Walter Nike , Schindler Melanie , Bärtl Susanne , Szymski Dominik , Alt Volker , Rupp Markus 
Published: April 2024

AimsPeriprosthetic joint infection (PJI) demonstrates the most feared complication after total joint replacement (TJR). The current work analyzes the demographic, comorbidity, and complication profiles of all patients who had in-hospital treatment due to PJI. Furthermore, it aims to evaluate the in-hospital mortality of patients with PJI and analyze possible risk factors in terms of secondary diagnosis, diagnostic procedures, and complications.MethodsIn a retrospective, cross-sectional study design, we gathered all patients with PJI (International Classification of Diseases (ICD)-10 code: T84.5) and resulting in-hospital treatment in Germany between 1 January 2019 and 31 December 2022. Data were provided by the Institute for the Hospital Remuneration System in Germany. Demographic data, in-hospital deaths, need for intensive care therapy, secondary diagnosis, complications, and use of diagnostic instruments were assessed. Odds ratios (ORs) with 95% confidence intervals (CIs) for in-hospital mortality were calculated.ResultsA total of 52,286 patients were included, of whom 1,804 (3.5%) died. Hypertension, diabetes mellitus, and obesity, the most frequent comorbidities, were not associated with higher in-hospital mortality. Cardiac diseases as atrial fibrillation, cardiac pacemaker, or three-vessel coronary heart disease showed the highest risk for in-hospital mortality. Postoperative anaemia occurred in two-thirds of patients and showed an increased in-hospital mortality (OR 1.72; p < 0.001). Severe complications, such as organ failure, systemic inflammatory response syndrome (SIRS), or septic shock syndrome showed by far the highest association with in-hospital mortality (OR 39.20; 95% CI 33.07 to 46.46; p < 0.001).ConclusionThese findings highlight the menace coming from PJI. It can culminate in multi-organ failure, SIRS, or septic shock syndrome, along with very high rates of in-hospital mortality, thereby highlighting the vulnerability of these patients. Particular attention should be paid to patients with cardiac comorbidities such as atrial fibrillation or three-vessel coronary heart disease. Risk factors should be optimized preoperatively, anticoagulant therapy stopped and restarted on time, and sufficient patient blood management should be emphasized.Cite this article: Bone Jt Open 2024;5(4):367–373.
Does neighbourhood deprivation influence low back pain and arthritis: An empirical study using multilevel twin design
Authors: Feng Yingyu , Bowden Jocelyn L. , Hunter David J. , Ferreira Paulo , Duncan Glen E. 
Published: April 2024

Objective
Neighbourhood deprivation has been found to be associated with many health conditions, but its association with low back pain (LBP) and arthritis is unclear. This study aimed to examine the association between neighbourhood deprivation with LBP and arthritis, and its potential interaction with individual socioeconomic status (SES) on these outcomes.

Methods
Monozygotic (MZ) twins from the Washington State Twin Registry were used to control for genetic and common environmental factors that could otherwise confound the purported relationship. Multilevel models were employed to examine the association between neighbourhood deprivation as well as individual-level SES with LBP/arthritis, adjusting for age, sex, body mass index (BMI) and residence rurality.

Results
There were 6,380 individuals in the LBP sample and 2,030 individuals in the arthritis sample. Neighbourhood deprivation was not associated with LBP (P = 0.26) or arthritis (P = 0.61), and neither was its interaction with individual-level SES. People without a bachelor’s degree were more likely to report LBP (OR 1.44, 95% CI 1.26–1.65) or both LBP and arthritis (OR 1.67, 95% CI 1.14–2.45) than those with a bachelor’s degree, but not for arthritis alone (P = 0.17). Household income was not significantly associated with LBP (P = 0.16) or arthritis (p = 0.23) independent of age, sex, and BMI.

Conclusion
Our study did not find significant associations between neighbourhood deprivation and the presence of LBP or arthritis. More research using multilevel modelling to investigate neighbourhood effects on LBP and arthritis is recommended.
Efficacy and safety of aripiprazole or bupropion augmentation and switching in patients with treatment-resistant depression or major depressive disorder: A systematic review and meta-analysis of randomized controlled trials
Authors: Ji Mengjia , Feng Junfei , Liu Guirong 
Published: April 2024

Objectives
To report the first and largest systematic review and meta-analysis of randomized controlled trials (RCT) to evaluate the efficacy and safety of aripiprazole or bupropion augmentation and switching in patients with treatment-resistant depression (TRD) or major depressive disorder(MDD).

Methods
We conducted a systematic literature retrieval via PubMed, Embase, Web of Science, and Cochrane until April 2023 for RCT, which evaluated the efficacy and safety of aripiprazole or bupropion augmentation and switching for patients with TRD or MDD. Outcomes measured were changes in the Montgomery-Asberg Depression Rating Scale (MADRS), response and remission rate, and serious adverse events.

Results
Five RCTs, including 4480 patients, were included for meta-analysis. Among them, two RCTs were rated as "high risk" in three aspects (allocation concealment, blinding of participants and personnel and blinding of outcome assessment) because of the non-blind method, and the quality evaluation of the remaining works of literature was "low risk". Augmentation treatment with Aripiprazole (A-ARI) was associated with a significant higher response rate compared with augmentation treatment with bupropion (A-BUP) (RR: 1.15; 95% CI: 1.05, 1.25; P = 0.0007; I2 = 23%). Besides, A-ARI had a significant higher remission rate compared with switching to bupropion (S-BUP) (RR: 1.22; 95% CI: 1.00, 1.49; P = 0.05; I2 = 59%) and A-BUP had a significant higher remission rate compared with S-BUP (RR: 1.20; 95% CI: 1.06, 1.36; P = 0.0004; I2 = 0%). In addition, there was no significant difference in remission rate(RR: 1.05; 95% CI: 0.94, 1.17; P = 0.42; I2 = 33%), improvement of MADRS(WMD: -2.07; 95% CI: -5.84, 1.70; P = 0.28; I2 = 70%) between A-ARI and A-BUP. No significant difference was observed in adverse events and serious adverse events among the three treatment strategies.

Conclusions
A-ARI may be a better comprehensive antidepressant treatment strategy than A-BUP or S-BUP for patients with TRD or MDD. More large-scale, multi-center, double-blind RCTs are needed to further evaluated the efficacy and safety of aripiprazole or bupropion augmentation and switching treatment strategies.
The role of sociodemographic factors on the acceptability of digital mental health care: A scoping review protocol
Authors: Abouzeid Nagi , Lal Shalini 
Published: April 2024

Introduction
Many individuals experiencing mental health complications face barriers when attempting to access services. To bridge this care gap, digital mental health innovations (DMHI) have proven to be valuable additions to in-person care by enhancing access to care. An important aspect to consider when evaluating the utility of DMHI is perceived acceptability. However, it is unclear whether diverse sociodemographic groups differ in their degree of perceived acceptability of DMHI.

Objective
This scoping review aims to synthesize evidence on the role of sociodemographic factors (e.g., age, gender) in the perceived acceptability of DMHI among individuals seeking mental health care.

Methods
Guided by the JBI Manual of Evidence Synthesis, chapter on Scoping Review, a search strategy developed according to the PCC framework will be implemented in MEDLINE and then adapted to four electronic databases (i.e., CINAHL, MEDLINE, PsycINFO, and EMBASE). The study selection strategy will be piloted by two reviewers on subsets of 30 articles until agreement among reviewers reaches 90%, after which one reviewer will complete the remaining screening of titles and abstracts. The full-text screening, data extraction strategy, and charting tool will be completed by one reviewer and then validated by a second member of the team. Main findings will be presented using tables and figures.

Expected contributions
This scoping review will examine the extent to which sociodemographic factors have been considered in the digital mental health literature. Also, the proposed review may help determine whether certain populations have been associated with a lower level of acceptability within the context of digital mental health care. This investigation aims to favor equitable access to DMHI among diverse populations.
On deferred f-statistical convergence for double sequences
Authors: Zhu Yahui , Shen Ang , Wang Zhongzhi , Peng Weicai 
Published: April 2024

Abstract
In this article, we first put forward the concept of deferred f-double natural density for double sequences, where f is an unbounded modulus. Then, we combine f-density with deferred statistical convergence for double sequences and investigate deferred f-statistical convergence and strongly deferred Cesàro summability with respect to modulus f. Moreover, we extend these concepts to deferred f-statistical convergence for double sequences of random variables in the Wijsman sense and prove some inclusions. Finally, we consider the concepts of deferred f-statistical convergence of order

α

\alpha

and strongly deferred f-summability of order

α

\alpha

for double sequences and obtain some conclusions.
When Sammy Gronemann Met Nathan Alterman: The Story of Israel’s Most Successful Comedy
Authors: Laor Dan 
Published: April 2024

Abstract
The essay delves into the intricate German-Jewish authorship and enduring legacy of the iconic Israeli musical, “King Solomon and Shalmai the Cobbler,” which premiered in Tel Aviv in 1943. Following its success, a contentious debate arose, overshadowing Sammy Gronemann’s rightful credit as the playwright, subsequently replaced by the prominence of his Hebrew translator, Nathan Alterman. This essay meticulously examines Gronemann’s pivotal contribution, illuminating his collaborative journey with Alterman from the vibrant cabaret scene of pre-state Tel Aviv to their lasting impact on contemporary Israeli culture and theater. By dissecting their creative partnership, it becomes evident that while Gronemann’s playwright prowess shone brightly and set new standards, Alterman’s adept translation skills bolstered the play’s success, thereby etching its indelible mark in Israeli theatrical history.
Biochar-mediated removal of various pollutants from the environment
Authors: Jeyaraj Samuel Gladstone , Hemavarshini Srinivasan , Shree GG Kavitha , Aravind Jeyaseelan 
Published: April 2024

Abstract
The growing concern regarding various environmentally hazardous pollutants has arisen due to their potential hazards to public health. Managing ecological concerns has become a pressing global priority. The utilisation of biochar in wastewater treatment to remove various hazardous substances impeded by its limited adsorption capacity, despite its low cost and good effectiveness. To enhance the efficiency of biochar in eliminating multiple pollutants, mixed methods have been used to change biochar and give it different physical and chemical properties; this results in distinctive adsorption outcomes, behaviours, and mechanisms. This study comprehensively analyses the efficient techniques, impacts, and mechanisms of modified biochar in eliminating hazardous substances, such as emerging contaminants, in the ecosystem. Modified biochar has enhanced efficacy in removing these substances, with removal processes mainly using adsorption and catalytic degradation pathways. Future endeavours should prioritise the development of uniform assessment standards for cost, efficacy, and environmental hazards while utilising emerging technologies to expand the potential uses of modified biochar to remove emerging contaminants.
Combined Effect of Multistage Processing and Treatment Methods on the Physical, Chemical, and Microstructure Properties of Recycled Concrete Aggregates
Authors: Sai Trivedi Shiv , Dixit Karunanidhi , Das Bibhuti Bhusan , Barbhuiya Salim 
Published: April 2024

Abstract
This research aims to examine the effects of multistage processing on reducing the old cement fractions and enhancing the quality of concrete recycled aggregate (CRA). The investigation involves the use of demolished concrete debris and subsequent treatments in both single and multistage processes. The recycled aggregates (RAs) were obtained using a multistage jaw crushing process followed by utilizing natural aggregate, untreated RA, RA treated with hydrochloric acid (HCl) and sodium silicate (SS) immersion (single-stage treatment), and RA treated with mechanical scrubbing and SS immersion in two separate stages (multistage treatment). The subsequent phase of the experimental inquiry involves assessing the physical attributes of both treated and untreated RA. This is followed by conducting microstructural examinations utilizing techniques such as scanning electron microscopy, energy-dispersive X-ray spectroscopy, X-ray diffraction, Fourier transform infrared spectroscopy (FTIR), and thermogravimetry-differential thermal analysis. The findings indicate that employing a two-step process, involving mechanical abrasion followed by immersion in SS, yields high-quality CRA. This conclusion is reinforced by the favorable physical performance observed. The water absorption values of CRA were lowered by 78 % through single-stage treatments such as immersion in HCl. The similar treatment is found to show densest concrete with calcium/silicon ratio reduced to around 81 % to that of untreated CRA. Additionally, for single-stage treated CRA samples, microstructural study using FTIR verified the creation of additional hydration products, whereas for two-stage treated CRA specimens, thermogravimetric analysis demonstrated the formation of stable CSH. According to the findings, it is advised to use a multistage process of jaw crushing, then treating it with mechanical abrasion and SS. This has the ability to improve the physical, chemical, and microstructural properties of CRA.
DRAMATURGY OF GENDER ROLES IN PERSONAL OUTREACH ON SOCIAL MEDIA THROUGH RELIGIOUS TEXTS
Authors: Saidah Musfiah , Maulidia Maya , Ningrum Diah Ayu Kusuma , Sahfi Rafiq Subhi 
Published: April 2024

Abstract. Social media, as a platform that allows individuals to share personal stories with a wide audience, has become an important vehicle for personal stories. Religious texts, on the other hand, are often used as a tool to articulate individual feelings and experiences, as well as provide moral and spiritual guidance. This study aims to explain how gender role dramaturgy occurs in personal accounts on social media through religious texts. Is there a difference in influence between men and women in sharing Islamic words through social media and how does dramaturgy theory answer this. This research is a type of field research. Data collection was carried out by interviewing, observing, and tracing written sources such as journals and articles related to the object of research. Meanwhile, data analysis was carried out using qualitative data analysis techniques. The results of this study found several points. First, what is the theory of dramaturgy. Second, the difference between men and women. Third, social media is a medium of da'wah. This research reveals that gender dramaturgy influences the way individuals compose and present their personal stories through religious texts on social media. This underscores the importance of understanding gender roles and social norms in social media content analysis, and the implications for how we understand individual identities and experiences in today's digital context. Abstrak. Media sosial, sebagai platform yang memungkinkan individu untuk berbagi kisah pribadi dengan khalayak luas, telah menjadi kendaraan penting untuk cerita-cerita personal. Di sisi lain, teks keagamaan sering digunakan sebagai alat untuk menyatakan perasaan dan pengalaman individu, serta memberikan panduan moral dan spiritual. Penelitian ini bertujuan untuk menjelaskan bagaimana dramaturgi peran gender terjadi dalam akun personal di media sosial melalui teks keagamaan. Apakah ada perbedaan pengaruh antara pria dan wanita dalam berbagi kata-kata Islami melalui media sosial, dan bagaimana teori dramaturgi menjawab hal ini. Penelitian ini merupakan jenis penelitian lapangan. Pengumpulan data dilakukan dengan wawancara, observasi, dan penelusuran sumber tertulis seperti jurnal dan artikel terkait objek penelitian. Sementara itu, analisis data dilakukan dengan menggunakan teknik analisis data kualitatif. Hasil penelitian ini menemukan beberapa poin. Pertama, apa itu teori dramaturgi. Kedua, perbedaan antara pria dan wanita. Ketiga, media sosial sebagai medium dakwah. Penelitian ini mengungkapkan bahwa dramaturgi gender memengaruhi cara individu menyusun dan menyajikan cerita pribadi mereka melalui teks keagamaan di media sosial. Hal ini menegaskan pentingnya memahami peran gender dan norma-norma sosial dalam analisis konten media sosial, dan implikasinya terhadap pemahaman identitas dan pengalaman individu dalam konteks digital saat ini.