bluuebunny/crossref_metadata_2025_split huggingface dataset:
Gastric adenocarcinoma mistakenly diagnosed as an eating disorder: Case report
Authors: Siew Leit‐Chin , Huang Chia , Fleming Judith 
Published: April 2009

AbstractObjective:A number of organic conditions may mimic the symptoms of an eating disorder, however, gastric outlet obstruction mimicking anorexia nervosa has rarely been reported.Method:We report the case of a 51‐year‐old female admitted to an eating disorders unit with an initial diagnosis of anorexia nervosa.Results:The patient's upper gastrointestinal symptoms and weight loss were found to be secondary to gastric outlet obstruction from a gastric adenocarcinoma. Coincidental psychosocial stressors and past psychiatric history, among other factors, had confounded the diagnosis.Discussion:Organic causes of weight loss and upper gastrointestinal symptoms need to be fully excluded prior to making the diagnosis of an eating disorder, particularly when there are atypical features in the presentation. © 2009 by Wiley Periodicals, Inc. Int J Eat Disord 2010
On testing for genetic association in case‐control studies when population allele frequencies are known
Authors: Antonyuk A. , Holmes C. 
Published: April 2009

AbstractWith the emergence of Biobanks alongside large‐scale genome‐wide association studies (GWAS) we will soon be in the enviable situation of obtaining precise estimates of population allele frequencies for SNPs which make up the panels in standard genotyping arrays, such as those produced from Illumina and Affymetrix. For disease association studies it is well known that for rare diseases with known population minor allele frequencies (pMAFs) a case‐only design is most powerful. That is, for a fixed budget the optimal procedure is to genotype only cases (affecteds). In such tests experimenters look for a divergence from allele distribution in cases from that of the known population pMAF; in order to test the null hypothesis of no association between the disease status and the allele frequency. However, what has not been previously characterized is the utility of controls (known unaffecteds) when available. In this study we consider frequentist and Bayesian statistical methods for testing for SNP genotype association when population MAFs are known and when both cases and controls are available. We demonstrate that for rare diseases the most powerful frequentist design is, somewhat counterintuitively, to actively discard the controls even though they contain information on the association. In contrast we develop a Bayesian test which uses all available information (cases and controls) and appears to exhibit uniformaly greater power than all frequentist methods we considered. Genet. Epidemiol. 33:371–378, 2009. © 2009 Wiley Liss, Inc.
A modified forward multiple regression in high‐density genome‐wide association studies for complex traits
Authors: Gu Xiangjun , Frankowski Ralph F. , Rosner Gary L. , Relling Mary , Peng Bo , Amos Christopher I. 
Published: April 2009

AbstractGenome‐wide association studies (GWAS) have been widely used to identify genetic effects on complex diseases or traits. Most currently used methods are based on separate single‐nucleotide polymorphism (SNP) analyses. Because this approach requires correction for multiple testing to avoid excessive false‐positive results, it suffers from reduced power to detect weak genetic effects under limited sample size. To increase the power to detect multiple weak genetic factors and reduce false‐positive results caused by multiple tests and dependence among test statistics, a modified forward multiple regression (MFMR) approach is proposed. Simulation studies show that MFMR has higher power than the Bonferroni and false discovery rate procedures for detecting moderate and weak genetic effects, and MFMR retains an acceptable‐false positive rate even if causal SNPs are correlated with many SNPs due to population stratification or other unknown reasons. Genet. Epidemiol. 33:518–525, 2009. © 2009 Wiley‐Liss, Inc.
A novel haplotype‐sharing approach for genome‐wide case‐control association studies implicates the calpastatin gene in Parkinson's disease
Authors: Allen Andrew S. , Satten Glen A. 
Published: April 2009

AbstractThe large number of markers considered in a genome‐wide association study (GWAS) has resulted in a simplification of analyses conducted. Most studies are analyzed one marker at a time using simple tests like the trend test. Methods that account for the special features of genetic association studies, yet remain computationally feasible for genome‐wide analysis, are desirable as they may lead to increased power to detect associations. Haplotype sharing attempts to translate between population genetics and genetic epidemiology. Near a recent mutation that increases disease risk, haplotypes of case participants should be more similar to each other than haplotypes of control participants; conversely, the opposite pattern may be found near a recent mutation that lowers disease risk. We give computationally simple association tests based on haplotype sharing that can be easily applied to GWASs while allowing use of fast (but not likelihood‐based) haplotyping algorithms and properly accounting for the uncertainty introduced by using inferred haplotypes. We also give haplotype‐sharing analyses that adjust for population stratification. Applying our methods to a GWAS of Parkinson's disease, we find a genome‐wide significant signal in the CAST gene that is not found by single‐SNP methods. Further, a missing‐data artifact that causes a spurious single‐SNP association on chromosome 9 does not impact our test. Genet. Epidemiol. 33:657–667, 2009. Published 2009 Wiley‐Liss, Inc.
A note on permutation tests for genetic association analysis of quantitative traits when variances are heterogeneous
Authors: Posthuma Danielle , de Koning Dirk‐Jan , Dolan Conor , Goddard Michael E. , Visscher Peter M. 
Published: April 2009

AbstractThe genetic dissection of quantitative traits, or endophenotypes, usually involves genetic linkage or association analysis in pedigrees and subsequent fine mapping association analysis in the population. The ascertainment procedure for quantitative traits often results in unequal variance of observations. For example, some phenotypes may be clinically measured whilst others are from self‐reports, or phenotypes may be the average of multiple measures but with the number of measurements varying. The resulting heterogeneity of variance poses no real problem for analysis, as long as it is properly modelled and thereby taken into account. However, if statistical significance is determined using an empirical permutation procedure, it is not obvious what the units of sampling are. We investigated a number of permutation approaches in a simulation study of an association analysis between a quantitative trait and a single nucleotide polymorphism. Our simulations were designed such that we knew the true p‐value of the test statistics. A number of permutation methods were compared from the regression of true on empirical p‐values and the precision of the empirical p‐values. We show that the best procedure involves an implicit adjustment of the original data for the effects in the model before permutation, and that other methods, some of which seemed appropriate a priori, are relatively biased. Genet. Epidemiol. 33:710–716, 2009. © 2009 Wiley‐Liss, Inc.
Simultaneously recorded EEG–fMRI: Removal of gradient artifacts by subtraction of head movement related average artifact waveforms
Authors: Sun Limin , Hinrichs Hermann 
Published: April 2009

AbstractElectroencephalograms (EEGs) recorded simultaneously with functional magnetic resonance imaging (fMRI) are corrupted by large repetitive artifacts generated by the switched MR gradients. Several methods have been proposed to remove these distortions by subtraction of averaged artifact templates from the ongoing EEG. Here, we present a modification of this approach which accounts for head movements to improve the extracted template. Using the fMRI analysis package statistical parametric mapping (SPM; FIL London) the head displacement is determined at each half fMRI‐volume. The basic idea is to apply a moving average algorithm for template extraction but to include only epochs that were obtained at the same head position as the artefact to be removed. This approach was derived from phantom EEG measurements demonstrating substantial variations of the artefact waveform in response to movements of the phantom in the MRI magnet. To further reduce the residual noise, we applied a resampling algorithm which aligns the EEG samples in a strict adaptive manner to the fMRI timing. Finally, we propose a new algorithm to suppress residual artifacts such as those occasionally observed in case of brief strong movements, which are not reflected by the movement indicator because of the limited temporal resolution of the fMRI sequence. On the basis of EEG recordings of six subjects these measures combined reduce the residual artefact activity quantified in terms of the spectral power at the gradient repetition rate and its harmonics by roughly 20 to 50% (depending on the amount of movement) predominantly in frequencies beyond 30 Hz. Hum Brain Mapp, 2009. © 2009 Wiley‐Liss, Inc.
Lateralization of the arcuate fasciculus from childhood to adulthood and its relation to cognitive abilities in children
Authors: Lebel Catherine , Beaulieu Christian 
Published: April 2009

AbstractThe arcuate fasciculus is a major white matter tract involved in language processing that has also been repeatedly implicated in intelligence and reasoning tasks. Language in the human brain is lateralized in terms of both function and structure, and while the arcuate fasciculus reflects this asymmetry, its pattern of lateralization is poorly understood in children and adolescents. We used diffusion tensor imaging (DTI) and tractography to examine arcuate fasciculus lateralization in a large (n = 183) group of healthy right‐handed volunteers aged 5–30 years; a subset of 68 children aged 5–13 years also underwent cognitive assessments. Fractional anisotropy and number of streamlines of the arcuate fasciculus were both significantly higher in the left hemisphere than the right hemisphere in most subjects, although some subjects (10%) were right lateralized. Age and gender effects on lateralization were not significant. Children receiving cognitive assessments were divided into three groups: a “left‐only” group in whom only the left side of the arcuate fasciculus could be tracked, a left‐lateralized group, and a right‐lateralized group. Scores on the Peabody Picture Vocabulary Test (PPVT) and NEPSY Phonological Processing task differed significantly among groups, with left‐only subjects outperforming the right‐lateralized group on the PPVT, and the left‐lateralized children scoring significantly better than the right‐lateralized group on phonological processing. In summary, DTI tractography demonstrates leftward arcuate fasciculus lateralization in children, adolescents, and young adults, and reveals a relationship between structural white matter lateralization and specific cognitive abilities in children. Hum Brain Mapp, 2009. © 2009 Wiley‐Liss, Inc.
A quantitative identification technique for a two‐dimensional subsurface defect based on surface temperature measurement
Authors: Fan Chunli , Sun Fengrui , Yang Li 
Published: April 2009

AbstractThe inverse identification of a subsurface defect boundary is an important part of an inverse heat conduction problem, and is also the basis for the quantitative development of a nondestructive thermographic inspection technique. For the commonly encountered quantitative thermographic defect identification problem when the test piece is heated from one part of the outer boundary, our previous study showed that some parts of the defect boundary are sensitive to the initial defect boundary prediction of the conjugate gradient method. In this paper, the heat transfer mechanism inside a test piece with this problem is analyzed by building a two‐dimensional model. A new method, the multiple measurements combination method (MMCM), is also presented which combines the identification algorithm study with the optimization of the thermographic detection technique to solve the problem. Numerical experiments certified the effectiveness of the present method. The temperature measurement error and the initial prediction of the defect boundary shape have little effect on the identification result. © 2009 Wiley Periodicals, Inc. Heat Trans Asian Res; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/htj.20251
Kinetic analysis on the drying of high moisture MSW
Authors: Chen Mei‐Qian , Chen Yun‐Xuan , Jia Li , Zhang Yan‐Guo , Li Qing‐Hai , Meng Ai‐Hong 
Published: April 2009

AbstractExperiments on the drying of high moisture municipal solid waste (MSW) were carried out in a muffle incinerator, and a series of lost‐mass rate curves were obtained. The results show that lost mass is already over 80% for a castock, but only 30% for a potato block after 25 minutes when the drying temperature is higher than 120°C. Arrhenius equations and the activation energies of the drying process of castock and a potato block from a drying temperature of 100°C to 200°C were obtained from experimental data. The results show that lower energy is required for completely drying castock and a potato block. © 2009 Wiley Periodicals, Inc. Heat Trans Asian Res; Published online in Wiley InterScience (www.interscience. wiley.com). DOI 10.1002/htj.20252
Numerical study of the intensified heat transfer of an internally longitudinal ridged finned tube under pulsating flow
Authors: Wu Feng , Wang Qiu‐Wang 
Published: April 2009

AbstractThe turbulent pulsating flow and heat transfer in an internally longitudinal protuberant finned tube was numerically investigated by solving unsteady three‐dimensional elliptical Navier–Stokes equations. The realized k–ϵ turbulent model was adopted. The dynamic behaviors of velocity field, average Nusselt number, and friction number of the internally longitudinal protuberant finned tube were numerically analyzed in a pulsating period, and it was further investigated by changing the frequency of the pulsating flow. It was found that the intensity of heat transfer enhancement increases with an increase of pulsating frequency, while the pressure drop will be increased simultaneously, the intensification of heat transfer in internally longitudinal protuberant finned tubes are gradually better than the pressure drop with an increase of pulsating frequency. © 2009 Wiley Periodicals, Inc. Heat Trans Asian Res; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/htj.20253
Common genetic variants and risk for non‐Hodgkin lymphoma and adult T‐cell lymphoma/leukemia in Jamaica
Authors: Wang Sophia S. , Carreon J. Daniel , Hanchard Barrie , Chanock Stephen , Hisada Michie 
Published: April 2009

AbstractWe evaluated whether risk of non‐Hodgkin lymphoma (NHL), particularly adult T‐cell leukemia/lymphoma (ATL) related to human T‐lymphotropic virus (HTLV) infection was associated with 63 single nucleotide polymorphisms (SNPs) from 38 candidate genes. The 395 NHL cases registered in Jamaica were matched by age, sex, calendar‐year and HTLV serostatus to 309 controls from the same population. Interleukin 13 (IL13) Ex4+98A>G SNP (rs20541) was associated with decreased NHL risk (ORAG/AA = 0.62,95% CI = 0.44–0.87, p = 0.006), as was vascular cell adhesion molecule‐1, VCAM1 Ex9+149G>A SNP (rs1041163) (ORCT = 0.77, 95% CI = 0.54–1.10, ORCC=0.35, 95% CI = 0.16–0.76, p‐trend = 0.007). Both results were stronger in analyses restricted to ATL cases and HTLV‐positive controls, suggesting a role for these genes in ATL etiology (IL13 ORAG/AA = 0.54, 95% CI = 0.36–0.84, p = 0.005; VCAM1 ORCT = 0.65, 95% CI = 0.42–1.01, ORCC = 0.20, 95% CI = 0.08–0.54, p‐trend = 0.001). Confirmation of these results in Caribbean and other populations is needed. © 2009 UICC
The role of diet and other environmental factors in the causation of gastric cancer in Iran—A population based study
Authors: Pourfarzi Farhad , Whelan Anna , Kaldor John , Malekzadeh Reza 
Published: April 2009

AbstractDespite a declining trend in the incidence of gastric cancer (GC), it is still a major global public health concern of the 21st century. The rates of GC reported from Ardabil Province, Iran, are among the highest in the world. To investigate risk factors for GC in Ardabil, we undertook a population‐based case‐control study. The study aimed to recruit all Ardabil residents newly diagnosed with GC in the time period of 2004–2005, and 2 controls per case. Participants were interviewed using a structured questionnaire. Ten milliliters of blood was collected for blood grouping and investigating the presence of IgG antibodies against Helicobacter pylori. During the study period, 217 people with GC and 394 controls were recruited. In multivariate analysis, diet and Helicobacter pylori infection (OR = 2.41; 95% CI: 1.35–4.32) were found to be the factors that were most strongly related to GC. High intake of Allium vegetables (OR = 0.35) and fruit, especially citrus fruit (OR = 0.31) and consumption of fresh fish (OR = 0.37) were significantly protective. On the other hand, consumption of red meat (OR = 3.40) and dairy products (OR = 2.28) were positively associated with the risk of GC. People who had a preference for higher salt intake (OR = 3.10) and drinking strong and hot tea (OR = 2.64 and 2.85, respectively) were at higher risk. In conclusion, Helicobacter pylori infection as measured by serum IgG as well as the consumption of red meat and dairy products increases the risk of GC in Ardabil, while the intake of fresh fruit and fresh fish decrease the risk. © 2009 UICC
Autophagy—A double‐edged sword in oncology
Authors: Apel Anja , Zentgraf Hanswalter , Büchler Markus W. , Herr Ingrid 
Published: April 2009

AbstractAutophagy or “self‐eating” digests proteins and functionless cell organelles to reuse. This cell‐own recycling system attracts much attention in tumour biology. One of the major functions of autophagy is maintaining cellular homeostasis. Thus, it is constitutive active in all living cells. Damaged or dispensable proteins and organelles are removed to regulate composition and size of the cytoplasm. Many therapeutic treatments have been shown to modulate autophagy signalling although it is still unclear if autophagy represents a survival or a suicide mechanism for tumour cells. Tumour growth in response to blocked autophagy as well as tumour growth in response to induced autophagy has been described. Several recent review articles address the differential effect of autophagy manipulation to apoptosis signalling. However, less has been reported about interactions of autophagy manipulation to the outcome of cancer therapy and tumour growth. Therefore, this review tries to fill this gap. We discuss data demonstrating that cellular decisions to autophagy manipulation depend on tumour type, stage, microenvironment, autophagy initiator or inhibitor and combined tumour treatment. Finally, we come to the conclusion that further analyses are necessary before manipulation of autophagic mechanisms can find its way into tumour therapy for improved treatment of patients. © 2009 UICC
Mutations of NFKBIA, encoding IκBα, are a recurrent finding in classical Hodgkin lymphoma but are not a unifying feature of non‐EBV‐associated cases
Authors: Lake Annette , Shield Lesley A. , Cordano Pablo , Chui Daniel T.Y. , Osborne Julie , Crae Shauna , Wilson Katherine S. , Tosi Sabrina , Knight Samantha J.L. , Gesk Stefan , Siebert Reiner , Hay Ron T. , Jarrett Ruth F. 
Published: April 2009

AbstractA consistent feature of the Hodgkin and Reed‐Sternberg (HRS) cells in classical Hodgkin lymphoma (cHL) is the constitutive activation of NF‐κB transcription factors. In Epstein‐Barr virus (EBV)‐associated cases of cHL, expression of viral antigens most probably leads to NF‐κB activation but for non‐EBV‐associated cases, the mechanism is not clear. Previous small studies have demonstrated deleterious mutations of NFKBIA, the gene encoding IκBα, in HRS cells. In the present study, we aimed to establish the frequency of NFKBIA mutation in cHL by investigating a larger series of cases and to determine whether these mutations are a characteristic feature of non‐EBV‐associated cHL. Single HRS cells from 20 cases of cHL were analysed by PCRs covering all 6 exons of the gene. Clonal deleterious mutations were detected in 3 cases and in 1 case both alleles of the gene were shown to harbour mutations. NFKBIA mutations were detected only in non‐EBV‐associated cases but the majority of these cases had wild‐type NFKBIA. It remains possible that defects in genes encoding other inhibitors of NF‐κB, such as TNFAIP3 (A20) and CYLD, are involved in the latter cases, as described for one case in this series. © 2009 UICC
Novel drug‐loaded gelatin films and their sustained‐release performance
Authors: Lin Mei , Meng Sheng , Zhong Wei , Cai Rui , Du Qiangguo , Tomasik Piotr 
Published: April 2009

AbstractA new particulate drug delivery system with gelatin matrix containing Ibuprofen as a model drug molecule was developed for an epidermis drug prolonged release. Gelatin films containing Ibuprofen‐loaded poly‐ε‐caprolactone (PCL) microspheres have been developed on evaporation of organic solvent from an oil‐in‐water emulsion followed by cross‐linking. The microspheres were characterized for particle size, encapsulation efficiency, and surface morphology. Water uptake, matrix erosion, and drug release profile of the microsphere‐film system were investigated. The results indicated that drug‐loaded microspheres introduced in this system successfully prolonged drug release time. This kind of microsphere‐film system combined good adhesion, typical for gelatin films, with the sustained release performance of PCL microspheres. © 2009 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2009
TRALI risk reduction: Donor and component management strategies
Authors: Eder Anne F. , Benjamin Richard J. 
Published: April 2009

AbstractTransfusion‐related lung injury (TRALI) occurs in ∼1 in 5,000 transfusions and may cause considerably more morbidity and mortality that is not recognized in clinical practice. Based on the current understanding of the etiology of TRALI, blood centers have implemented or are evaluating various donor and component management strategies in an effort to mitigate the risk of TRALI. Many cases of TRALI are likely caused by antibodies to leukocyte antigens (HLA or HNA) in blood components. Approximately 10 to 20% of female blood donors with a history of pregnancy and 1 to 5% of male blood donors harbor these antibodies. Alternatively, TRALI may be mediated by other bioactive lipids or substances that accumulate during storage and cause a reaction when transfused to susceptible patients. The complex interplay among various donor‐, component‐, and patient‐related factors underlying TRALI guarantees that effective prevention will not be a single or simple intervention but rather will require a multifaceted approach. Perhaps, the most important risk reduction strategy is the effort to ensure appropriate use of blood products and eliminate unnecessary transfusions. Blood collection agencies, however, have more proximate control over donor selection and component management than transfusion practice. AABB has provided some guidance on deferring donors implicated in TRALI and minimizing the preparation of high plasma volume components from donors who have anti‐leukocyte antibodies or are at increased risk of leukocyte alloimmunization. Blood centers have taken various approaches to mitigate the risk of TRALI, and the possible benefit and the inherent limitations of the current strategies will be reviewed. J. Clin. Apheresis 2009. © 2009 Wiley‐Liss, Inc.