bluuebunny/crossref_metadata_2025_split huggingface dataset:
Bibliometric analysis of a comprehensive of culture＆symbol in Character animation during (2004–2024)
Authors: Yang Chen , Jamali Siti Salmi , Husain Adzira 
Published: April 2024

Abstract

The analysis of academic research on animated characters in the animation industry effectively summarises the current state of scholarly research on animated characters through a variety of software tools such as CiteSpace, VOS viewer, HistCite, and Bibliometrix analysis, and visually charts and formulates this data. Through study and research, it that the United States is (278) the most prolific country, and the United States has the highest intermediary centrality, as well as the most Centre National de la Recherche Scientifique (CNRS) and PEOPLES R CHINA are the most cited organizations and Countries/Regions with the highest intermediary centrality and Countries/Regions with the highest citation explosiveness, respectively. This study also suggests possible challenges and future directions in character design for animated characters.
Thiousulfate Leaching in Carbonaceous Gold-Bearing Ores in Ethiopia
Authors: Chaka Kaleb , Rupprecht Steven 
Published: April 2024

Abstract

One of the main unit operations in metallurgical processing plant designs is gold leaching. The traditional cyanidation process was chosen and is currently in widespread use. However, the mining sector is looking for lixiviants other than cyanide. Cyanide's effects on the environment have made it difficult for humans and other biotic creatures to survive. There is now research to discover a substitute for this cyanide. It is currently argued that thiosulfate is a preferable substitute for cyanide. The effectiveness of thiosulfate as a leaching agent in carbonaceous gold-bearing ores in Ethiopia is discussed in this paper compared to cyanide. The study has looked into the advantages of employing thiosulfate over cyanide from a technical, environmental, and economic standpoint. The leaching effects of both lixiviants on carbonaceous gold-bearing ores extracted from MIDROC Legadembi Open Pit mine in Southern Ethiopia, Oromia region, were examined in a laboratory experiment. After 48 hours of leaching, it was discovered that thiosulfate has a better and quicker recovery of 91.54% over 61.70% of cyanide recovery. Tables and graphs are used to demonstrate thiosulfate's technical advantage over cyanide. As a result, this paper provides evidence regarding the Legadembi gold mine in Ethiopia's amenability to thiosulfate leaching on carbonaceous gold-bearing ores. A further research perspective is also sought for thiosulfate leaching in other refractory ores.
Pulmonary nocardiosis due to Nocardia otitidiscaviarum in an immunocompetent host:A case report and literature review
Authors: Wan Junjun , Feng Feifei 
Published: April 2024

Abstract

BackgroundNocardia otitidiscaviarum is a relatively rare pathogen that belongs to the distinctive species within the Nocardia genus. It is typically found in soil or decaying matter and can enter the body through a break in the skin or, less commonly, through the respiratory tract. Pneumonic nocardial disease is an uncommon infection that primarily affects immunocompromised individuals.
Case presentationThis article presents a case study of a pneumonic nocardiosis infection in a 22-year-old immunocompetent female with symptoms of fever, cough, and sputum production. The patient had no prior history of diabetes, was not on steroid therapy, had no adverse lifestyle habits, and had not been diagnosed with tuberculosis previously. A chest CT scan revealed suppurative inflammation in both lungs. Bronchoscopy was conducted, and alveolar lavage fluid was collected and sent for culture and next-generation sequencing (NGS). NGS results confirmed the presence of Nocardia otitidiscaviarum within 24 hours. After 96 hours of conventional laboratory culture, positive colonies were observed. The morphological features of bacteria in these colonies were consistent with Nocardia otitidiscaviarum, as confirmed by Gram staining. The patient received precise antibiotic treatment and showed positive outcome. We conducted a review of previously documented cases involving infections caused by Nocardia otitidiscaviarum.
ConclusionsEnhanced recognition of the diverse presentations of Nocardia otitidiscaviarum could potentially elevate the survival rate of this otherwise lethal condition.
Simulation analysis of pressure relief effect of upward mining in the lower protective layer (group) of deep extra-thick coal seam
Authors: Qin Guangpeng , zhang zhenyu , Cao Jing , Ma Jinpeng , Zhang Xueyuan 
Published: April 2024

Abstract

In this paper, an examination of the upward mining of multi-protected layers through simulation is conducted in a mine in Dongsheng Coal Field, China, as an example. FLAC3D numerical simulation software was used to calculate the mining scheme of the lower protected layer (group) and analyze the stress changes and pressure unloading characteristics of the protected layer during the mining process. Similar simulation experiments were conducted to provide additional explanations on the characteristics of fissure development in the overburden rock layer and the expansion and deformation characteristics of the protected layer during the mining process. The test results show that the stress distribution curve of the protected layer can be divided into four parts: the original rock stress area, the stress concentration area, the stress reduction area, and the stress recovery area. The bending deformation of the coal seam is evident after the completion of mining the lower protected seam group, and the expansion deformation area undergoes three processes: increasing, decreasing, and stabilizing. Overall, the unloading rate and length of double-protected seam mining are much larger than those of single-protected seam mining, providing an engineering basis for the mining of deep extra-thick coal seam protected seam (group).
Personalized glucose prediction using in situ data only
Authors: Salathé Marcel , Toumi Marouane , Singh Rohan 
Published: April 2024

Abstract

The worldwide rise in blood glucose levels is a major health concern, as various metabolic diseases become increasingly common. Diet, a modifiable health behavior, is a primary target for the preventive management of glucose levels. Recent studies have shown that blood glucose responses after meals (post-prandial glucose responses, PPGR) can vary greatly among individuals, even with identical food consumption, and suggested that the gut microbiota might play an important role in these differences. While accurate glucose response prediction has been achieved using various features like microbiome data and blood parameters, the exact influence of each individual factor on the prediction is still not clear. Here, we show that a machine learning algorithm with data collected from a digital cohort with over 1,000 participants can achieve high accuracy in PPRG prediction. Interestingly, we find that the best PPGR prediction model only requires glycemic and temporally resolved diet data. The demonstrated ability to predict PPGR with high accuracy using only data collected in situ, without the need for biological lab analysis, offers a path towards highly scalable personalized nutrition and glucose management strategies.
Overexpression of Heme oxygenase 1 enhances the neuroprotective effects of exosomes in subarachnoid hemorrhage by suppressing oxidative stress and endoplasmic reticulum stress
Authors: Gao Qiongqiong , Su Zhumin , Pang Xiangxiong , Chen Jinshuo , Luo Ruixiang , Li Xiaoyang , Zhang Chi , Zhao Yun 
Published: April 2024

Abstract

Aims: To investigate the therapeutic effects and potential mechanism of exosomes from Heme oxygenase 1 (HO-1)-overexpressing human umbilical cord mesenchymal stem cells (ExoHO-1) on subarachnoid hemorrhage (SAH) mice.
Methods: Western blotting, particles analyzer, and transmission electron microscopy were used to identify the exosomes. Garcia scoring system, Beam balance, Rotarod test, and Morris water maze test were performed to assessed the effect of ExoHO-1 and ExoCtrl on neurological function of SAH mice. TUNEL and Nissl staining were used to examinate the neuron apoptosis. Immunofluorescence, Western blotting, DHE, Enzyme-linked immunosorbent assay, and commercial kits were used to examine the levels of oxidative stress and endoplasmic reticulum stress.
Results: HO-1-overexpressing human umbilical cord mesenchymal stem cells loaded HO-1 into their exosomes. ExoHO-1 exhibited a significantly beneficial effects on short-term and long-term neurological function protecting. By reducing activation of PERK/CHOP/Caspase12 pathway and levels of oxidative stress, ExoHO-1 more effectively inhibited neuronal apoptosis in ipsilateral temporal cortex.
Conclusion: HO-1 over-expression enhanced the therapy of exosomes on the SAH mice by against neuronal apoptosis in SAH. These therapeutic effects are likely through suppressing the oxidative stress and endoplasmic reticulum stress.
The Influence of Patient Awareness on the Incidence and Severity of Pain During Propofol Injection: A Randomized Controlled Study.
Authors: bahr mahmoud , abdelaal ahmed , abdelbadie mohamed , moaz doaa 
Published: April 2024

Abstract

Background: Propofol, a widely utilized intravenous anaesthetic agent for induction and maintenance of anaesthesia, is renowned for its rapid onset and brief duration. However, discomfort associated with its injection is reported in approximately 20% to 90% of cases, negatively impacting patient satisfaction and procedural safety.
Objectives: The primary aim of this study was to assess the influence of patient awareness regarding the potential for pain during propofol injection on both the occurrence rate and severity of the pain experienced. The assessment of pain scores associated with propofol injection served as the principal endpoint of the investigation.
Methods: This randomised, controlled trial was conducted at Beni-Suef University Hospital with approval from the anaesthesiology department, the surgical ICU, pain management, and the hospital's ethical committee. A total of 210 patients participated in the study, randomly allocated into two groups: Group A (Aware), informed about the potential for pain associated with propofol injection, and Group B (Unaware), not informed of this possibility.
Results: Statistical analysis revealed significant differences between the groups in terms of verbal categorical scoring (VCS) and the numerical rating scale (NRS) across various pain intensity levels (0, 1-3, 4-6, 7-9, and 10). However, no significant differences were observed regarding age, weight, and the American Society of Anaesthesiology (ASA) classification.
Conclusion: The findings underscore the significant impact of patient awareness on the experience of pain during propofol injection. Educating patients about the possibility of pain may influence their perception and reporting of pain intensity, suggesting a need for tailored patient communication strategies in clinical practice.
Resolving Mega-Dams Energy-Water Nexus in the Eastern Nile Basin During Prolonged Droughts
Authors: Heggy Essam , Abotalib Abotalib , You Jongeun , Hanert Emmanuel , Ramah Mohamed 
Published: April 2024

Abstract

Optimizing hydropower generation from mega-dams during prolonged droughts while minimizing downstream water deficits is decisive to resolving the ongoing major conflict on transboundary river management in the highly populous Eastern Nile basin. Our study provides comprehensive assessments of the efficiency of multiple drought-mitigation operation policies based on the outcomes of negotiations. In addition, we develop four novel policies that reduce potential adverse downstream impacts and maximize upstream hydropower generation during prolonged droughts. We use a multi-reservoir hydraulic-energy model with the most up-to-date entries to simulate and optimize the hydropower generation and reservoir level response of the two Nile's largest mega-dams, Grand Ethiopian Resonance Dam (GERD) and Aswan High Dam (AHD), utilizing 100 years of historical flow records. Our results show that, during wet and average flow conditions and a temporary drought, GERD can generate maximum hydropower without a noticeable downstream deficit. However, for prolonged droughts, GERD can still generate sustainable energy from more than 87% of its maximum hydropower while minimizing the dam-induced downstream water budget deficit to a manageable volume. Our up-to-date findings can reduce the negotiations' disparities on operating Nile’s hydropower mega-dams during prolonged drought and help reach a collaborative framework to mitigate the threats of rising hydroclimatic fluctuations.
The Introduction of a 42 + 4 Hour Work Week for Surgical Residents in Switzerland – a Stakeholder Analysis
Authors: Antony Pia , Kalkum Eva , MK Muller , Hager L , Probst Pascal 
Published: April 2024

Abstract

Background
The Swiss national union of residents and attendings (VSAO) has voiced its desire for a transition to a 42 + 4h work week, in which 42h be focued on patient care with the remaining 4h be dedicated solely to training purposes. This could potentially result in a decrease of 20% in surgical education time. The current study seeks to address the issues involved in its implementation as well as possible compensatory mechanisms.
Methods
This mixed methods study seeks to clearly underline the challenges associated with the implementation of a 42 + 4h work week. First, the major stakeholders were identified and analysed via umbrella review. Thereafter, a classic stakeholder analysis was performed. Via morphological matrix, possible models for the implementation of a 42 + 4h work week were developed and evaluated. Finally, representatives from the identified stakeholder groups were interviewed and given the opportunity to provide feedback.
Results
A total of 26 articles were identified by the literature search and were used to identify the major stakeholders and issues involved in the implementation of the desired work hour regulation. Overall, these showed conflicting results with regard to the effect decreased working hours would have on surgical training and patient outcomes. In the end, the morphological matrix produced three feasible and desirable models for the implementation of a 42 + 4h work week. Each included compensatory mechanisms like auxiliary staff, reduction in administrative tasks, and a switch to EPAs. In their interviews, the stakeholders generally supported these solutions.
Conclusion
Given the increasing emphasis on the importance of a positive work-life balance, it seems inevitable that the next few years will see the introduction of a 42 + 4h work week in Switzerland. However, it is imperative that every effort be made to preserve the quality of training and patient care for the next generations. This will require the cooperation of all stakeholders in order to find workable solutions.
Initial signs in patients with ruptured abdominal aortic aneurysms - Time for an expanded triad?
Authors: Bergmark Peter , Sadeghi Mitra , Talvitie Mareia , Hultgren Re 
Published: April 2024

Abstract

Objective Misdiagnosis of ruptured abdominal aortic aneurysms (rAAA) contributes to delayed treatment and potentially higher mortality. The symptomatology in patients with rAAA is complex and challenging, 25–50% presumably fulfill the criteria of the standard triad of signs (STS). The objective was to determine the initial signs registered for patients with verified rAAAs, and to investigate if an expanded diagnostic triad could increase the diagnostic accuracy.Methods A population-based study was conducted among all patients presenting with verified rAAAs in Stockholm County, Sweden, from January 2010 to October 2021. Patients were identified with ICD code 171.3 (rAAA). The STS was defined as 1) abdominal pain, 2) syncope and 3) the finding of a pulsatile abdominal mass, the prevalence of STS was investigated. An expanded triad included similar and related signs commonly registered for patients with rAAA, and was referred to as the modified abdominal aortic aneurysm rupture signs (MARS). The MARS-signs encompassed 1) the registered pain-associated symptoms or signs, 2) all hypovolemic associated signs, and 3) pulsatile abdominal mass and/or ultrasound finding, and the prevalence was similarly investigated. Finally, the STS and MARS were compared to evaluate the usefulness and performance of the MARS-score.Results A total of 216 patients were identified. The majority were men (77%) with a mean age of 77 years. The dominating symptom was abdominal pain (84%), followed by dizziness (50%). Few patients presented with three STS (13%), two STS were found in 37% and one STS in almost half of the patients (41%). By contrast, when applying MARS 35% presented with the complete expanded triad, 47% with two and 17% with one. Comparison of accuracy favored MARS (13% vs 35% with 3 signs, p < 0.001 for STS vs. MARS) (2 or 3 signs, 48% vs 82% STS vs MARS, p < 0.001).Conclusions The expanded MARS-signs could aid in easier and faster identification of rAAA patients, thus facilitating the first step with accurate diagnosis into the lifesaving rAAA care chain. Supportive diagnostic mnemonics and tools are especially important when targeting fatal diagnoses such as rAAA. Further studies are needed to investigate the implementation of the MARS-signs in various clinical settings.
Rare Serious Etiologies in Patients Admitted to Pediatric Clinics with Acquired Torticollis
Authors: SEÇİLMİŞ YILMAZ , GÜLEÇ AYTEN , DURMUŞ NİMETULLAH ALPER , GÜMÜŞ ÜMMÜGÜLSÜM ÖZGÜL , ÖZTÜRK SELCAN , CANPOLAT MEHMET , BÜLBÜL EMRE , ORAL ŞÜKRÜ , GÖKALP EMİR , PER HÜSEYİN 
Published: April 2024

Abstract

Purpose
Torticollis is a clinical symptom characterized by an abnormal head posture. It can be caused by simple muscle-related pathologies, space-occupying lesions, neurological diseases, genetic disorders, or even ophthalmic pathologies. In this study, we evaluated the underlying etiologies in patients admitted to pediatric emergency departments and pediatric clinics due to torticollis.
Methods
This retrospective study included 13 patients admitted with torticollis between July 1, 2018, and December 1, 2021.
Results
Four patients had cranial pathologies, including cerebellar ependymoma, choroid plexus carcinoma, pontine glioma, and diffuse astrocytoma. One patient had a demyelinating disorder: anti-myelin oligodendrocyte glycoprotein (MOG antibody)-associated disease (MOGAD). Three patients had spinal pathologies, including atlantoaxial subluxation, vertebral osteoblastoma, and spinal dural arteriovenous fistula. Two patients presented with ear, nose, and throat pathologies; specifically, laryngomalacia and reactive lymph nodes. One patient had epilepsy, one had ocular pathologies (strabismus and esotropia), and one had a rare neurodegenerative genetic disorder resulting in epileptic encephalopathy.
Conclusions
Torticollis is a symptom that may indicate serious underlying conditions. When evaluating children with torticollis, it is important to consider the possibility of a posterior fossa tumor until it is ruled out. Radiologic imaging and a comprehensive ophthalmologic examination should be performed, especially to assess intracranial and ocular pathologies, even if theneurological examination appears normal. This report presents a case of torticollis associated with MOGAD, which, to the best of our knowledge, has not been previously reported. Additionally, the report discusses a wide spectrum of torticollis presentations, including an extremely rare case involving a patient with ADPRHL2mutation who presented with paroxysmal torticollis and developed progressive neurodegeneration. These findings emphasize the importance of investigating multiple underlying etiologies of torticollis.
Sequential use of midazolam and Remimazolam besylate for sedation in critically ill, mechanically ventilated patients: a randomized controlled study
Authors: liu renhuai , Su Binxiao , Gan Guifen , Wang Guangming , Wang Chengli , Xu Ning , Feng Guangcai , Guo Hao , Yuan Qingxia , Li Aiguang , Zheng Wenping , Li Jiang , Chen Yu , Zhang Xijing 
Published: April 2024

Abstract

Background: Previous research has indicated that the administration of short-acting sedatives prior to weaning from mechanical ventilation is linked to a more rapid recovery and extubation process, as well as to lower intensive care unit (ICU) treatment expenses. The present study endeavors to assess the efficacy and safety of the sequential application of remimazolam besylate compared with midazolam before weaning from mechanical ventilation.
Methods: This multicenter, randomized controlled trial was conducted across medical and surgical ICU within a tertiary, academic medical center. The study population comprised critically ill, mechanically ventilated adult patients. Candidates anticipated to be ready for weaning from the ventilator within 12 hours were subjected to a Spontaneous Breathing Trial (SBT) safety screen, only those who successfully passed this assessment were considered for inclusion in the final phase of the study for subsequent randomization.
Patients were randomized to either group M, where the sedative regimen was transitioned to midazolam, or to group R, which involved a switch to remimazolam. Sedative dosages were titrated to achieve the targeted Richmond Agitation-Sedation Scale (RASS) score range of -3 to 0. The primary endpoint of the stud was the time to extubation.
Results: A total of 435 patients underwent screening, with 306 patients being randomized, and 272 patients ultimately included in the analysis, comprising 132 patients in group M and 140 patients in group R. Patients in group R maintained a lighter level of sedation compared to those in group M. And patients in group R demonstrated a significantly earlier recovery (P<0.05) and extubation (P<0.05) at the same RASS score before the cessation of sedatives. A higher prevalence of agitation was observed in group M as opposed to group R (20.45% vs. 8.57%, P=0.005). However, there was no notable difference in the incidence of delirium between the two groups.
Conclusions: In critically ill, mechanically ventilated patients receiving remimazolam besylate exhibited a shorter time to recovery and extubation before weaning from the ventilator, coupled with a diminished incidence of agitation.
Trial registration: ChiCTR 2200065048. Registered October 22. 2022