bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prosocial emotions predict individual differences in economic decision-making during ultimatum game with dynamic reciprocal contexts
Authors: Kim Jaewon , Bong Su Hyun , Yoon Dayoung , Jeong Bumseok 
Published: May 2024

AbstractSocial decision-making is known to be influenced by predictive emotions or the perceived reciprocity of partners. However, the connection between emotion, decision-making, and contextual reciprocity remains less understood. Moreover, arguments suggest that emotional experiences within a social context can be better conceptualised as prosocial rather than basic emotions, necessitating the inclusion of two social dimensions: focus, the degree of an emotion's relevance to oneself or others, and dominance, the degree to which one feels in control of an emotion. For better representation, these dimensions should be considered alongside the interoceptive dimensions of valence and arousal. In an ultimatum game involving fair, moderate, and unfair offers, this online study measured the emotions of 476 participants using a multidimensional affective rating scale. Using unsupervised classification algorithms, we identified individual differences in decisions and emotional experiences. Certain individuals exhibited consistent levels of acceptance behaviours and emotions, while reciprocal individuals' acceptance behaviours and emotions followed external reward value structures. Furthermore, individuals with distinct emotional responses to partners exhibited unique economic responses to their emotions, with only the reciprocal group exhibiting sensitivity to dominance prediction errors. The study illustrates a context-specific model capable of subtyping populations engaged in social interaction and exhibiting heterogeneous mental states.
Mathematical modeling of hypoxia and adenosine to explore tumor escape mechanisms in DC-based immunotherapy
Authors: Ghiyabi Elahe , Arabameri Abazar , Charmi Mostafa 
Published: May 2024

AbstractIdentifying and controlling tumor escape mechanisms is crucial for improving cancer treatment effectiveness. Experimental studies reveal tumor hypoxia and adenosine as significant contributors to such mechanisms. Hypoxia exacerbates adenosine levels in the tumor microenvironment. Combining inhibition of these factors with dendritic cell (DC)-based immunotherapy promises improved clinical outcomes. However, challenges include understanding dynamics, optimal vaccine dosages, and timing. Mathematical models, including agent-based, diffusion, and ordinary differential equations, address these challenges. Here, we employ these models for the first time to elucidate how hypoxia and adenosine facilitate tumor escape in DC-based immunotherapy. After parameter estimation using experimental data, we optimize vaccination protocols to minimize tumor growth. Sensitivity analysis highlights adenosine’s significant impact on immunotherapy efficacy. Its suppressive role impedes treatment success, but inhibiting adenosine could enhance therapy, as suggested by the model. Our findings shed light on hypoxia and adenosine-mediated tumor escape mechanisms, informing future treatment strategies. Additionally, identifiability analysis confirms accurate parameter determination using experimental data.
Land scale division and multifunctional evaluation for Fuping County, China, based on DEM-based watershed analysis
Authors: Yin Haikui , Wang Shutao , Chen Yaheng , Zhou Yapeng , Chen Yuqi , Xu Hao 
Published: May 2024

AbstractLand is the spatial background and basic carrier of human survival and development. The study of land function evaluation at different scales can promote the harmonious coexistence of humans and nature. Taking Fuping County, Hebei Province, China, as an example, this study establishes the theoretical framework of county-level land scale division using a digital elevation model (DEM)-based watershed analysis method and establishes the theory and methodological system of land function evaluation from the perspective of the characteristic scale. The multifunctionality of the land was evaluated using the Carnegie–Ames–Stanford approach (CASA), the Integrated Valuation of Ecosystem Services and Trade-offs (InVEST) model and comprehensive index evaluation. By using the methods of DEM-based watershed analysis, dominant factor differentiation and layer superposition, a three-level scale system of ‘subwatershed scale-land chain scale-land segment scale’ and a multifunctional multiscale evaluation index system containing 18 evaluation indices were established. The single-function and multifunction evaluation results of land at different scales were obtained by the comprehensive index method and Getis-Ord Gi* index method. The accuracy of land function evaluation results mainly depends on the selection of the measurement scale. The land measurement scale determined by DEM-based watershed analysis is close to the intrinsic scale of land function evaluation. The scale effect of land function in different temporal and spatial ranges is also evident and shows obvious spatial heterogeneity and difference. At larger scales, individual functions show synergistic effects.
Immediate and delayed placement of the intrauterine device after abortion: a systematic review and meta-analysis
Authors: Lou Ying , Tang Shanshan , Sheng Zhumei , Lian Hongqin , Yang Jingjing , Jin Xuejing 
Published: May 2024

AbstractThis article aims to report the comprehensive and up-to-date analysis and evidence of the insertion rate, expulsion rate, removal rate, and utilization rate of immediate placement of intrauterine devices (IUDs) versus delayed placement after artificial abortion. PubMed, Embase, Cochrane, Web of Science, CNKI, and Wanfang databases were comprehensively searched up to January 12, 2024 for studies that compared immediate versus delayed insertion of IUDs after abortion. The evaluation metrics included the number of IUD insertion after surgical or medical abortions, the frequency of expulsion and removal at 6 months or 1 year, the number of continued usage, pain intensity scores, the number of infections, the duration of bleeding, and instances of uterine perforation during or after IUD insertion. Ten randomized controlled articles were eligible, comprising 11 research projects, of which 3 projects involved the placement of an IUD after surgical abortion, and 8 projects involved the placement of an IUD after medical abortion. This included 2025 patients (977 in the immediate insertion group and 1,048 in the delayed insertion group). We summarized all the extracted evidence. The meta-analysis results indicated that for post-surgical abortions, the immediate insertion group exhibited a higher IUD placement rate than the delayed insertion group. After medical abortions, the immediate insertion group showed higher rates of IUD placement, utilization, and expulsion at 6 months or 1 year. The two groups showed no statistically significant differences in the removal rate, post-insertion infection rate, pain scores during insertion, and days of bleeding during the follow-up period. Compared to delayed placement, immediate insertion of IUDs can not only increase the usage rate at 6 months or 1 year but also enhance the placement rate.
A real-world pharmacovigilance study of FDA adverse event reporting system events for Capmatinib
Authors: Qi Yiming , Li Jing , Lin Sisi , Wu Shuangshuang , Chai Kequn , Jiang Xin , Qian Jiancheng , Jiang Cheng 
Published: May 2024

AbstractCapmatinib is a potent selective mesenchymal-epithelial transition inhibitor approved in 2020 for the treatment of metastatic non-small cell lung cancer. As real-world evidence is very limited, this study evaluated capmatinib-induced adverse events through data mining of the FDA Adverse Event Reporting System database. Four disproportionality analysis methods were employed to quantify the signals of capmatinib-related adverse events. The difference in capmatinib-associated adverse event signals was further investigated with respect to sex, age, weight, dose, onset time, continent, and concomitant drug. A total of 1518 reports and 4278 adverse events induced by capmatinib were identified. New significant adverse event signals emerged, such as dysphagia, dehydration, deafness, vocal cord paralysis, muscle disorder, and oesophageal stenosis. Notably, higher risk of alanine aminotransferase and aspartate aminotransferase increases were observed in females, especially when capmatinib was combined with immune checkpoint inhibitors. Compared with Europeans and Asians, Americans were more likely to experience peripheral swelling, especially in people > 65 years of age. Renal impairment and increased blood creatinine were more likely to occur with single doses above 400 mg and in Asians. This study improves the understanding of safety profile of capmatinib.
A validated web-application (GFDC) for automatic classification of glaucomatous visual field defects using Hodapp-Parrish-Anderson criteria
Authors: Thirunavukarasu Arun James , Jain Nikhil , Sanghera Rohan , Lattuada Federico , Mahmood Shathar , Economou Anna , Yu Helmut C. Y. , Bourne Rupert 
Published: May 2024

AbstractSubjectivity and ambiguity of visual field classification limits the accuracy and reliability of glaucoma diagnosis, prognostication, and management decisions. Standardised rules for classifying glaucomatous visual field defects exist, but these are labour-intensive and therefore impractical for day-to-day clinical work. Here a web-application, Glaucoma Field Defect Classifier (GFDC), for automatic application of Hodapp-Parrish-Anderson, is presented and validated in a cross-sectional study. GFDC exhibits perfect accuracy in classifying mild, moderate, and severe glaucomatous field defects. GFDC may thereby improve the accuracy and fairness of clinical decision-making in glaucoma. The application and its source code are freely hosted online for clinicians and researchers to use with glaucoma patients.
Fast, accurate, and interpretable decoding of electrocorticographic signals using dynamic mode decomposition
Authors: Fukuma Ryohei , Majima Kei , Kawahara Yoshinobu , Yamashita Okito , Shiraishi Yoshiyuki , Kishima Haruhiko , Yanagisawa Takufumi 
Published: May 2024

AbstractDynamic mode (DM) decomposition decomposes spatiotemporal signals into basic oscillatory components (DMs). DMs can improve the accuracy of neural decoding when used with the nonlinear Grassmann kernel, compared to conventional power features. However, such kernel-based machine learning algorithms have three limitations: large computational time preventing real-time application, incompatibility with non-kernel algorithms, and low interpretability. Here, we propose a mapping function corresponding to the Grassmann kernel that explicitly transforms DMs into spatial DM (sDM) features, which can be used in any machine learning algorithm. Using electrocorticographic signals recorded during various movement and visual perception tasks, the sDM features were shown to improve the decoding accuracy and computational time compared to conventional methods. Furthermore, the components of the sDM features informative for decoding showed similar characteristics to the high-γ power of the signals, but with higher trial-to-trial reproducibility. The proposed sDM features enable fast, accurate, and interpretable neural decoding.
TBC9, an essential TBC-domain protein, regulates early vesicular transport and IMC formation in Toxoplasma gondii
Authors: Sun Ming , Tang Tao , He Kai , Long Shaojun 
Published: May 2024

AbstractApicomplexan parasites harbor a complex endomembrane system as well as unique secretory organelles. These complex cellular structures require an elaborate vesicle trafficking system, which includes Rab GTPases and their regulators, to assure the biogenesis and secretory of the organelles. Here we exploit the model apicomplexan organism Toxoplasma gondii that encodes a family of Rab GTPase Activating Proteins, TBC (Tre-2/Bub2/Cdc16) domain-containing proteins. Functional profiling of these proteins in tachyzoites reveals that TBC9 is the only essential regulator, which is localized to the endoplasmic reticulum (ER) in T. gondii strains. Detailed analyses demonstrate that TBC9 is required for normal distribution of proteins targeting to the ER, and the Golgi apparatus in the parasite, as well as for the normal formation of daughter inner membrane complexes (IMCs). Pull-down assays show a strong protein interaction between TBC9 and specific Rab GTPases (Rab11A, Rab11B, and Rab2), supporting the role of TBC9 in daughter IMC formation and early vesicular transport. Thus, this study identifies the only essential TBC domain-containing protein TBC9 that regulates early vesicular transport and IMC formation in T. gondii and potentially in closely related protists.
Generation and maintenance of the circularized multimeric IS26-associated translocatable unit encoding multidrug resistance
Authors: Aihara Masamune , Gotoh Yasuhiro , Shirahama Saki , Matsushima Yuichi , Uchiumi Takeshi , Kang Dongchon , Hayashi Tetsuya 
Published: May 2024

AbstractIn gram-negative bacteria, IS26 often exists in multidrug resistance (MDR) regions, forming a pseudocompound transposon (PCTn) that can be tandemly amplified. It also generates a circular intermediate called the “translocatable unit (TU)”, but the TU has been detected only by PCR. Here, we demonstrate that in a Klebsiella pneumoniae MDR clone, mono- and multimeric forms of the TU were generated from the PCTn in a preexisting MDR plasmid where the inserted form of the TU was also tandemly amplified. The two modes of amplification were reproduced by culturing the original clone under antimicrobial selection pressure, and the amplified state was maintained in the absence of antibiotics. Mono- and multimeric forms of the circularized TU were generated in a RecA-dependent manner from the tandemly amplified TU, which can be generated in RecA-dependent and independent manners. These findings provide novel insights into the dynamic processes of genome amplification in bacteria.
Endothelial ROBO4 suppresses PTGS2/COX-2 expression and inflammatory diseases
Authors: Tanaka Masato , Shirakura Keisuke , Takayama Yui , Μatsui Miki , Watanabe Yukio , Yamamoto Takuya , Takahashi Junya , Tanaka Shota , Hino Nobumasa , Doi Takefumi , Obana Masanori , Fujio Yasushi , Takayama Kazuo , Okada Yoshiaki 
Published: May 2024

AbstractAccumulating evidence suggests that endothelial cells can be useful therapeutic targets. One of the potential targets is an endothelial cell-specific protein, Roundabout4 (ROBO4). ROBO4 has been shown to ameliorate multiple diseases in mice, including infectious diseases and sepsis. However, its mechanisms are not fully understood. In this study, using RNA-seq analysis, we found that ROBO4 downregulates prostaglandin-endoperoxide synthase 2 (PTGS2), which encodes cyclooxygenase-2. Mechanistic analysis reveals that ROBO4 interacts with IQ motif-containing GTPase-activating protein 1 (IQGAP1) and TNF receptor-associated factor 7 (TRAF7), a ubiquitin E3 ligase. In this complex, ROBO4 enhances IQGAP1 ubiquitination through TRAF7, inhibits prolonged RAC1 activation, and decreases PTGS2 expression in inflammatory endothelial cells. In addition, Robo4-deficiency in mice exacerbates PTGS2-associated inflammatory diseases, including arthritis, edema, and pain. Thus, we reveal the molecular mechanism by which ROBO4 suppresses the inflammatory response and vascular hyperpermeability, highlighting its potential as a promising therapeutic target for inflammatory diseases.
Improved interfacial stability of all-solid-state batteries using cation-anion co-doped glass electrolytes
Authors: Rajagopal Rajesh , Subramanian Yuvaraj , Kang Sung , Park Jungjae , Ryu Kwang-Sun 
Published: May 2024

AbstractThe electrochemical performance of all-solid-state batteries needs to be improved by addressing the poor stability against the lithium metal anode and the high interfacial resistance at the cathode–solid electrolyte interface. Here, metal halide-doped Li7P2S8I–type (LPSI) solid electrolytes are synthesized that improve the electrochemical performance of all-solid-state batteries. The solid electrolytes exhibit a higher ionic conductivity value of 7.77 mS cm−1 than bare LPSI solid electrolytes of 3.96 mS cm−1, at room temperature. The metal halide-doped LPSI solid electrolyte is also stable against the lithium metal anode, with a calculated critical current density value of 1 mA cm−2. The fabricated all-solid-state battery shows high electrochemical performance with 99.2% specific capacity retention after 250 cycles at a 0.5 C rate. The results of post galvanostatic charge–discharge analysis confirms that the proposed metal halide-doped LPSI solid electrolyte exhibits improved interfacial stability compared to bare LPSI solid electrolytes.
Measuring global monetary damages from particulate matter and carbon dioxide emissions to track sustainable growth
Authors: Mohan Aniruddh , Muller Nicholas Z. , Thyagarajan Akshay , Martin Randall V. , Hammer Melanie S. , Donkelaar Aaron van 
Published: May 2024

AbstractAn integrated framework that tracks global stocks and flows of natural capital is needed to assess sustainable economic growth. Here, we develop a set of globally comprehensive monetary damages from particulate matter air pollution and greenhouse gas emissions in 165 countries from 1998 to 2018. Our results show that pollution intensity began to rise after a decade during which the global economy became less pollution-intensive from the late 1990s until the Great Recession. Larger economic production shares and higher pollution intensity in China and India drove this change. Deducting pollution damage from output from the late 1990s until the Great Recession yields higher growth estimates. After the Great Recession, this adjustment for pollution damage attenuated growth. We show that modeling monetary damages instead of physical measures of environmental quality affects inferences about sustainable development. Further, the monetary damages from exposure to particulate emissions peak earlier in the development path than damages due to carbon dioxide emissions. Monetary damages peak later than physical measures of both pollutants. For carbon dioxide, per capita emissions maximize at just over 60,000 dollars while monetary damages peak at nearly 80,000 dollars. In 2018, all but two countries were below this income level. Our results suggest that the global economy is likely to exhibit rising damages from particulates and carbon dioxide emissions in the years to come as nations grow and develop.
2D Conductive Metal–Organic Frameworks for Electrochemical Energy Application
Authors: Li Ruofan , Yan Xiaoli , Chen Long 
Published: May 2024

Two-dimensional conductive metal–organic frameworks (2D c-MOFs) have attracted research attention, benefitting from their unique properties such as superior electronic conductivity, designable topologies, and well-defined catalytic/redox-active sites. These advantages enable 2D c-MOFs as promising candidates in electrochemical energy applications, including supercapacitors, batteries and electrocatalysts. This mini-review mainly highlights recent advancements of 2D c-MOFs in the utilization for electrochemical energy storage, as well as the forward-looking perspective on the future prospects of 2D c-MOFs in the field of electrochemical energy.Table of content:1 Introduction2 Design Principles of 2D c-MOFs3 Synthesis of 2D c-MOFs4 2D c-MOFs for Electrochemical Energy Storage4.1 Supercapacitors4.2 Metallic Batteries4.2.1 Lithium-Ion Batteries4.2.2 Sodium-Ion Batteries4.2.3 Zinc-Ion Batteries4.2.4 Sodium–Iodine Batteries4.2.5 Lithium–Sulfur Batteries4.2.6 Potassium-Ion Batteries5 2D c-MOFs for Electrochemical Energy Conversion6 Conclusions and Outlook
Finding the needle in the haystack: archival research in European political science
Authors: Klein Alexander 
Published: May 2024

AbstractThis short article offers a practical introduction to archival research for political scientists working on European politics. Archival documents are increasingly recognized as a relevant data source for process tracing analyses in small-N or mixed methods studies. Previously classified archival documents are exceptionally trustworthy due to their original confidentiality. Their rich and detailed content facilitates the understanding of causal mechanisms. Still, the hurdles for working with archival sources are high for political scientists. Lack of experience, no special training in handling historic documents, and a shortage of textbooks meeting their demands are a few of the problems political scientists planning archival research face. In the article, I highlight the opportunities of archival research and demonstrate how challenges can be overcome. I emphasize that the archival field trip should only be planned once researchers have gained substantive context knowledge. In their preparation, researchers should use all the resources archives offer and develop measurable expectations from theories.
Chinese bayberry extract regulates the permeability of blood–cerebrospinal fluid barrier and ameliorates experimental colitis-related brain comorbidities in mice
Authors: Huang Ziwei , Yan Jialang , Liu Yilong , Fan Fuxiang , Liu Tian , Yin Yuanxiao , Li Junhao , Li Xian , Zheng Yixiong 
Published: May 2024

Abstract

Objectives
Anxiety, depression symptoms, and cognitive decline related to inflammatory bowel disease (IBD) are recognized to have an impact on patients’ health. The blood–cerebrospinal fluid barrier (BCSFB) is important in somatic disease-related psychiatric and cognitive disorders; however, few treatments show efficacy. The objective of this research was to determine the protective effect of Chinese bayberry extract on IBD-related brain comorbidities.

Materials and Methods
C57BL/6J mice were induced with dextran sulfate sodium solution to establish an experimental model, followed by the administration of Chinese bayberry extract. Oxidative stress indexes, immunofluorescence of choroid plexus, and BCSFB permeability were further investigated.

Results
Chinese bayberry extract improved behavioral markers and reduced the level of oxidative stress in the brain. In addition, the administration of the bayberry extract increased the tight junction proteins in the choroid plexus and significantly decreased in the permeability of the BCSFB.

Conclusions
Chinese bayberry extract has a potential therapeutic effect on relieving inflammatory bowel disease-related brain comorbidities. The underlying mechanism is associated with a decrease in oxidative stress in the brain and a decrease in the permeability of the BCSFB.