bluuebunny/crossref_metadata_2025_split huggingface dataset:
Knowledge of nurses working at schools in Bialystok, Poland, of tooth avulsion and its management
Authors: Baginska Joanna , Wilczynska‐Borawska Magdalena 
Published: November 2011

Abstract –  Aim:  The purpose of this study was to evaluate the knowledge of first aid in tooth avulsion among nurses working at schools in Bialystok, Poland. A part of this population attended a lecture on the management of dental trauma 2 years before.Methods:  The survey was conducted in September 2010 and covered 50 (96.15%) school nurses from Bialystok. Thirty‐eight of them attended the dental trauma lecture conducted 2 years before the survey. They were asked to fill in an anonymous questionnaire consisting of 20 closed questions referring to demographic data, previous dental trauma experience, and training. Seven questions referred directly to the knowledge of management of dental avulsion and on that basis, the level of nurses’ knowledge was evaluated. The data were analyzed statistically using the Mann–Withney U‐test with P < 0.05 to find factors influencing the level of knowledge.Results:  The study showed that nurses’ knowledge about tooth avulsion was at an appropriate level. 86% of the participants chose the correct definition of the term of replantation, 92% understood that the time is crucial for the result of a replantation, 94% knew that an avulsed tooth should be held by the crown, and 96% pointed the proper transport medium. A half of the surveyed nurses declared that they would provide tooth replantation and another 16% would consult the procedures by calling a dentist. One statistically significant correlation between the level of knowledge and previous dental trauma training was revealed (P < 0.01).Conclusions:  The lay knowledge of tooth avulsion in the population of nurses working at schools in Bialystok, Poland, was at an appropriate level. There was a strong correlation between this level and the participation in the lecture on the management of dental trauma conducted 2 years before.
Magical Thinking in Trademark Law
Authors: Assaf Katya 
Published: November 2011

People in all societies have a tendency toward magical thinking. This human inclination is extensively exploited by modern advertising, which routinely suggests that consuming goods will make us successful, happy, and fulfilled. In this article, I suggest that such advertising creates a system of beliefs resembling a totemic religion. In this religion, brands perform the role of sacred objects.
Trademark law initially aims at preventing consumer confusion. Yet, today, famous trademarks are extensively protected against nonconfusing associations. I argue in this article that this broad protection is based on magical thinking. Pointing out the parallels between the laws of magic and trademark doctrines, such as the doctrine of dilution, I suggest that famous marks are legally treated as magical, sacred objects. This legal approach amounts to endorsing the commercial religion of brands.
Influence of donor age, post‐mortem time and cold storage on metabolic profile of human cornea
Authors: Kryczka Tomasz , Szaflik Jacek P. , Szaflik Jerzy , Midelfart Anna 
Published: November 2011

Abstract.Purpose:  Limited knowledge exists about the influence of donor age and death‐to‐preservation interval (DPI) on the metabolic properties of the cornea. The aim of this study is to investigate the relationship between both factors and metabolite content of the cornea.Methods:  Corneas from 15 human donors (age: 41–78 years) were obtained within 16 hrs post‐mortem and kept in cold storage for 8 days. The metabolic profiles of the samples were investigated using high‐resolution, magic angle spinning 1H nuclear magnetic resonance spectroscopy before and after 8 days of preservation.Results:  Twenty‐two metabolites were detected and assigned in the corneal spectra. The significant metabolic differences before and after hypothermic storage were revealed between younger and older donors. DPI‐related significant differences revealed before preservation of the corneas were not displayed after 8 days of cold storage.Conclusions:  Age of donor as well as post‐mortem time influences the biochemical properties of the cornea. Cold storage decreases the metabolite differences between the tissues collected at different post‐mortem time.
Ultrafast and scalable cone‐beam CT reconstruction using MapReduce in a cloud computing environment
Authors: Meng Bowen , Pratx Guillem , Xing Lei 
Published: November 2011

Purpose:Four‐dimensional CT (4DCT) and cone beam CT (CBCT) are widely used in radiation therapy for accurate tumor target definition and localization. However, high‐resolution and dynamic image reconstruction is computationally demanding because of the large amount of data processed. Efficient use of these imaging techniques in the clinic requires high‐performance computing. The purpose of this work is to develop a novel ultrafast, scalable and reliable image reconstruction technique for 4D CBCT/CT using a parallel computing framework called MapReduce. We show the utility of MapReduce for solving large‐scale medical physics problems in a cloud computing environment.Methods:In this work, we accelerated the Feldcamp–Davis–Kress (FDK) algorithm by porting it to Hadoop, an open‐source MapReduce implementation. Gated phases from a 4DCT scans were reconstructed independently. Following the MapReduce formalism, Map functions were used to filter and backproject subsets of projections, and Reduce function to aggregate those partial backprojection into the whole volume. MapReduce automatically parallelized the reconstruction process on a large cluster of computer nodes. As a validation, reconstruction of a digital phantom and an acquired CatPhan 600 phantom was performed on a commercial cloud computing environment using the proposed 4D CBCT/CT reconstruction algorithm.Results:Speedup of reconstruction time is found to be roughly linear with the number of nodes employed. For instance, greater than 10 times speedup was achieved using 200 nodes for all cases, compared to the same code executed on a single machine. Without modifying the code, faster reconstruction is readily achievable by allocating more nodes in the cloud computing environment. Root mean square error between the images obtained using MapReduce and a single‐threaded reference implementation was on the order of 10−7. Our study also proved that cloud computing with MapReduce is fault tolerant: the reconstruction completed successfully with identical results even when half of the nodes were manually terminated in the middle of the process.Conclusions:An ultrafast, reliable and scalable 4D CBCT/CT reconstruction method was developed using the MapReduce framework. Unlike other parallel computing approaches, the parallelization and speedup required little modification of the original reconstruction code. MapReduce provides an efficient and fault tolerant means of solving large‐scale computing problems in a cloud computing environment.
Does more cycling also reduce the risk of single-bicycle crashes?
Authors: Schepers Paul 
Published: November 2011

ObjectiveThis paper examines the relationship between the amount of bicycle use and the number of single-bicycle crashes (ie, only one cyclist involved) in Dutch municipalities. Previous research has focused on crashes between bicycles and motor vehicles; however, most cyclists admitted to hospital are victims of single-bicycle crashes.MethodsThis correlational study used three data sets which included data relating to single-bicycle crashes and kilometres travelled by bicycle. Negative binomial regression was used to compare the amount of bicycling with the number of injuries incurred in single-bicycle crashes in Dutch municipalities.ResultsThe likelihood of single-bicycle crashes varied inversely with the level of bicycle use. The exponent for the change in the number of single-bicycle crashes in response to changes in bicycle volumes was <1 in all analyses (ie, the increase in the number of single-bicycle crashes in a given municipality is proportionally less than the increase in the number of bicycle kilometres travelled by its inhabitants). The value was reduced in analyses of single-bicycle crashes with more severe injuries.ConclusionsCyclists are less likely to be involved in a severe single-bicycle crash in municipalities with a high amount of cycling. Given the large numbers of patients admitted to hospital as a result of single-bicycle crashes, it is important to include the risks of these in road safety and health effect evaluations, and to take into account the non-linearity of the relationship between single-bicycle crashes and bicycle use if road safety measures are to affect the level of bicycle use.
Proximal analysis and toxicity of extracts from young and mature leaves of the boldo tree (Peumus boldus) on elm leaf beetle (Xanthogaleruca luteola)
Authors: Chiffelle Italo , Huerta Amanda , Jiménez Rodrigo , Araya Jaime E. 
Published: November 2011

A series of pests have been detected in plantations and urban trees, affecting directly the economy and recreational areas. The elm leaf beetle, Xanthogaleruca luteola Müller (Coleoptera: Chrysomelidae), is an insect pest that skeletonises the leaves of Ulmus spp., trees with a great ornamental value, which can become completely defoliated. The boldo tree (Peumus boldus Molina) is an evergreen plant endemic in Chile that contains secondary metabolites. Proximal analysis and insecticidal effects of extracts obtained from young and mature leaves with water and ethanol from P. boldus were evaluated at various concentrations on X. luteola under laboratory conditions in a completely randomized experiment considering two leaf maturity stages and solvents. Dry weight, water content, ash, and crude fiber leaf flour were significantly different between maturity stages, but the percentage of lipids and proteins were similar. Also, the 50% lethal concentration (LC50) was determined for each extract. The extracts obtained with both solvents were effective in controlling X. luteola adults in the laboratory, reaching over 50% average mortality at concentrations greater than 3.6% (w/v) in the young leaf extract and 4.0% (w/v) in the mature leaf extract. The lowest LC50 was 1.2% (w/v), obtained from the young leaf extract with ethanol after 48 h. This bioinsecticide from the leaves of P. boldus suggests an interesting opportunity for use in integrated pest management of X. luteola.
Assessing model performance in forecasting long-term individual tree diameter versus basal area increment for the primary Acadian tree species
Authors: Russell Matthew B. , Weiskittel Aaron R. , Kershaw John A. 
Published: November 2011

Tree basal area (ba) or diameter at breast height (dbh) are universally used to represent tree secondary growth in individual tree based growth models. However, the long-term implications of using either ba or dbh for predictions are rarely fully assessed. In this analysis, Δba and Δdbh increment equations were fit to identical datasets gathered from six conifer and four hardwood species grown in central Maine. The performance of Δba and Δdbh predictions from nonlinear mixed-effects models were then compared with observed growth measurements of up to 29 years via a Monte Carlo simulation. Two evaluation statistics indicated substantial improvement in forecasting dbh using Δdbh rather than Δba. Root mean squared error (RMSE) and percentage mean absolute deviation (MAD%) were reduced by 14% and 15% on average, respectively, across all projection length intervals (5–29 years) when Δdbh was used over Δba. Differences were especially noted as projection lengths increased. RMSE and MAD% were reduced by 24% when Δdbh was employed over Δba at longer projection lengths (up to 29 years). Simulations found that simulating random effects rather than using local estimates for random effects performed as well or better at longer interval lengths. These results highlight the implications that selecting a growth model dependent variable can have and the importance of incorporating model uncertainty into the growth projections of individual tree based models.
A comparison of the effects of different shelterwood harvest methods on the survival and growth of acorn-origin oak seedlings
Authors: Brose Patrick H. 
Published: November 2011

Timely development of newly germinated oak (Quercus spp.) seedlings into competitive-sized regeneration is an essential part of the oak regeneration process. The amount of sunlight reaching the forest floor partly governs this development, and foresters often use the shelterwood system to expose oak seedlings to varying degrees of insolation. To further understand the seedling development–sunlight–shelterwood relationships, I conducted a multiyear study at five locations in Pennsylvania. Each location had four stands either uncut or recently treated with one of three shelterwood harvest methods (preparatory cut, first removal cut, or final removal cut) resulting in four different levels of sunlight reaching the forest floor. In each stand, four 32 m2 plots were prepared, and each was planted with 400 acorns of black (Quercus velutina Lam.), chestnut (Quercus montana Willd.), northern red (Quercus rubra L.), or white oak (Quercus alba L.) and protected from wildlife. Germination success was universally high and for the next 8 years, I monitored seedling survival and measured seedling growth. The final and first removal cut treatments had higher seedling survival than the preparatory cut and uncut treatments. Oak seedling growth was positively related to sunlight availability; seedlings in the final removal cut grew the most, followed in descending order by those in the first removal cut, preparatory cut, and uncut treatments. These findings provide insight into the subtleties of regenerating oak forests with the shelterwood system.
Eastern hemlock (Tsuga canadensis) regeneration in the presence of hemlock woolly adelgid (Adelges tsugae) and elongate hemlock scale (Fiorinia externa)
Authors: Preisser Evan L. , Miller-Pierce Mailea R. , Vansant Jacqueline , Orwig David A. 
Published: November 2011

The hemlock woolly adelgid (Adelges tsugae Annand) is an invasive hemipteran that poses a major threat to eastern hemlock (Tsuga canadensis (L.) Carrière) forests in the United States. We conducted three surveys over a five-year period that assessed the density of hemlock woolly adelgid (HWA) and a second invasive pest, the elongate hemlock scale (EHS; Fiorinia externa Ferris), overstory hemlock mortality, and hemlock regeneration in ~140 hemlock stands (mean size, 44 ha; range, 7–305 ha) within a 7500 km2 north–south transect of southern New England (USA). In each stand, we rated HWA and EHS density on 50 hemlock trees using a 0–3 scale (0, none; 1, 1–10 organisms/m branch; 2, 11–100 organisms/m branch; 3, >100 organisms/m branch). Data on the presence or absence of regeneration were taken in 2005; in 2007 and 2009, we quantitatively assessed regeneration by counting the number of hemlock seedlings in three 16 m2 plots per stand. In 2005, 81% of sampled stands had HWA, 72% had EHS, and 66% had hemlock regeneration. In 2007, 86% of sampled stands had HWA, 79% had EHS, and 46% had hemlock regeneration. In 2009, 91% of stands had HWA, 87% had EHS, and 37% had hemlock regeneration. The proportion of stands with hemlock regeneration declined 46% between 2005 and 2009, and hemlock seedling density declined 71% between 2007 and 2009. A best-fit model selection algorithm found that this decrease was inversely correlated with stand-level adelgid density. There was no correlation between the change in seedling density and stand-level density of the elongate hemlock scale. The apparent decline in regeneration suggests that the ecosystem-level changes currently occurring in southern New England may be difficult to reverse.
Androgen Deprivation Causes Epithelial–Mesenchymal Transition in the Prostate: Implications for Androgen-Deprivation Therapy
Authors: Sun Yuting , Wang Bu-Er , Leong Kevin G. , Yue Peng , Li Li , Jhunjhunwala Suchit , Chen Darrell , Seo Kyounghee , Modrusan Zora , Gao Wei-Qiang , Settleman Jeffrey , Johnson Leisa 
Published: November 2011

Abstract
Androgen deprivation is currently a standard-of-care, first-line therapy for prostate cancer in the United States. Although this regimen effectively regresses androgen-dependent disease, relapse often occurs in an androgen-independent manner and is associated with poor prognosis. Such castration-resistant prostate cancer represents a major clinical challenge, and the mechanisms underlying castration resistance are not fully understood. Epithelial–mesenchymal transition (EMT) is a key developmental process and has also been implicated in cancer metastasis and therapeutic resistance in recent years. However, the factors contributing to EMT in human cancers remain unclear. Here, we show that both normal mouse prostate tissue and human LuCaP35 prostate tumor explants display an EMT as well as increased stem cell–like features following androgen deprivation. Importantly, we observed similar changes in mesenchymal features in prostate tumors from patients treated with androgen-deprivation therapy. In addition, we have delineated a feedback loop involving the androgen receptor and the Zeb1 transcription factor that seems to mediate this transition. In summary, we show for the first time that androgen deprivation induces EMT in both normal prostate and prostate cancer, revealing a potentially important consequence of a standard-of-care treatment for prostate cancer. This finding could have significant implications for second-line treatment strategies in this clinical setting. Cancer Res; 72(2); 527–36. ©2011 AACR.
Low-Flow, Low-Gradient Severe Aortic Stenosis Despite Normal Ejection Fraction Is Associated With Severe Left Ventricular Dysfunction as Assessed by Speckle-Tracking Echocardiography
Authors: Adda Jérôme , Mielot Christopher , Giorgi Roch , Cransac Frédéric , Zirphile Xavier , Donal Erwan , Sportouch-Dukhan Catherine , Réant Patricia , Laffitte Stéphane , Cade Stéphane , Le Dolley Yvan , Thuny Franck , Touboul Nathalie , Lavoute Cécile , Avierinos Jean-François , Lancellotti Patrizio , Habib Gilbert 
Published: November 2011

Background—
Low-flow low-gradient (LFLG) is sometimes observed in severe aortic stenosis (AS) despite normal ejection fraction, but its frequency and mechanisms are still debated. We aimed to describe the characteristics of patients with LFLG AS and assess the presence of longitudinal left ventricular dysfunction in these patients.

Methods and Results—

In a multicenter prospective study, 340 consecutive patients with severe AS and normal ejection fraction were studied. Longitudinal left ventricular function was assessed by 2D-strain and global afterload by valvulo-arterial impedance. Patients were classified according to flow and gradient: low flow was defined as a stroke volume index ≤35 mL/m
2
, low gradient as a mean gradient ≤40 mm Hg. Most patients (n=258, 75.9%) presented with high-gradient AS, and 82 patients (24.1%) with low-gradient AS. Among the latter, 52 (15.3%) presented with normal flow and low gradient and 30 (8.8%) with LFLG. As compared with normal flow and low gradient, patients with LFLG had more severe AS (aortic valve area=0.7±0.12 cm
2
versus 0.86±0.14 cm
2
), higher valvulo-arterial impedance (5.5±1.1 versus 4±0.8 mm Hg/mL/m
2
), and worse longitudinal left ventricular function (basal longitudinal strain=−11.6±3.4 versus −14.8±3%;
P
<0.001 for all).

Conclusions—
LFLG AS is observed in 9% of patients with severe AS and normal ejection fraction and is associated with high global afterload and reduced longitudinal systolic function. Patients with normal-flow low-gradient AS are more frequent and present with less severe AS, normal afterload, and less severe longitudinal dysfunction. Severe left ventricular longitudinal dysfunction is a new explanation to the concept of LFLG AS.
Recombinant factor IX-Fc fusion protein (rFIXFc) demonstrates safety and prolonged activity in a phase 1/2a study in hemophilia B patients
Authors: Shapiro Amy D. , Ragni Margaret V. , Valentino Leonard A. , Key Nigel S. , Josephson Neil C. , Powell Jerry S. , Cheng Gregory , Thompson Arthur R. , Goyal Jaya , Tubridy Karen L. , Peters Robert T. , Dumont Jennifer A. , Euwart Donald , Li Lian , Hallén Bengt , Gozzi Peter , Bitonti Alan J. , Jiang Haiyan , Luk Alvin , Pierce Glenn F. 
Published: November 2011

Abstract
Current factor IX (FIX) products display a half-life (t1/2) of ∼ 18 hours, requiring frequent intravenous infusions for prophylaxis and treatment in patients with hemophilia B. This open-label, dose-escalation trial in previously treated adult subjects with hemophilia B examined the safety and pharmacokinetics of rFIXFc. rFIXFc is a recombinant fusion protein composed of FIX and the Fc domain of human IgG1, to extend circulating time. Fourteen subjects received a single dose of rFIXFc; 1 subject each received 1, 5, 12.5, or 25 IU/kg, and 5 subjects each received 50 or 100 IU/kg. rFIXFc was well tolerated, and most adverse events were mild or moderate in intensity. No inhibitors were detected in any subject. Dose-proportional increases in rFIXFc activity and Ag exposure were observed. With baseline subtraction, mean activity terminal t1/2 and mean residence time for rFIXFc were 56.7 and 71.8 hours, respectively. This is ∼ 3-fold longer than that reported for current rFIX products. The incremental recovery of rFIXFc was 0.93 IU/dL per IU/kg, similar to plasma-derived FIX. These results show that rFIXFc may offer a viable therapeutic approach to achieve prolonged hemostatic protection and less frequent dosing in patients with hemophilia B. The trial was registered at www.clinicaltrials.gov as NCT00716716.
Role of TRPM8 in dorsal root ganglion in nerve injury-induced chronic pain
Authors: Su Lin , Wang Chao , Yu Yong-hao , Ren Yong-ying , Xie Ke-liang , Wang Guo-lin 
Published: November 2011

Abstract

Background
Chronic neuropathic pain is an intractable pain with few effective treatments. Moderate cold stimulation can relieve pain, and this may be a novel train of thought for exploring new methods of analgesia. Transient receptor potential melastatin 8 (TRPM8) ion channel has been proposed to be an important molecular sensor for cold. Here we investigate the role of TRPM8 in the mechanism of chronic neuropathic pain using a rat model of chronic constriction injury (CCI) to the sciatic nerve.

Results
Mechanical allodynia, cold and thermal hyperalgesia of CCI rats began on the 4th day following surgery and maintained at the peak during the period from the 10th to 14th day after operation. The level of TRPM8 protein in L5 dorsal root ganglion (DRG) ipsilateral to nerve injury was significantly increased on the 4th day after CCI, and reached the peak on the 10th day, and remained elevated on the 14th day following CCI. This time course of the alteration of TRPM8 expression was consistent with that of CCI-induced hyperalgesic response of the operated hind paw. Besides, activation of cold receptor TRPM8 of CCI rats by intrathecal application of menthol resulted in the inhibition of mechanical allodynia and thermal hyperalgesia and the enhancement of cold hyperalgesia. In contrast, downregulation of TRPM8 protein in ipsilateral L5 DRG of CCI rats by intrathecal TRPM8 antisense oligonucleotide attenuated cold hyperalgesia, but it had no effect on CCI-induced mechanical allodynia and thermal hyperalgesia.

Conclusions
TRPM8 may play different roles in mechanical allodynia, cold and thermal hyperalgesia that develop after nerve injury, and it is a very promising research direction for the development of new therapies for chronic neuroapthic pain.