bluuebunny/crossref_metadata_2025_split huggingface dataset:
High‐Performance Pressure and Temperature Dual‐Mode Sensor Based on Thermoelectric Aerogels for Multimodal Intellectual Panel Application
Authors: Jiang Saihua , Wang Zubin , Li Shun , Huang Yubing , Lan Yang , Li Guohui 
Published: February 2025

AbstractDeveloping sensors with multi‐sensory detection capabilities will streamline integrated systems and simplify the integration process. Herein, dual‐mode temperature and pressure sensors based on PEDOT: PSS/CNTs/CNF/MXene (PCCM) is established. In terms of temperature sensing, the aerogel structure and introduction of MXene provide ultra‐low thermal conductivity, ensuring a stable temperature gradient. The addition of CNTs forms an excellent conductive network, significantly enhancing temperature sensing performance and achieving a maximum Seebeck coefficient of 28.2 µV K−1, the introduction of MXene ensures PCCM the output electrical signal has ultra‐low noise and a high signal‐to‐noise ratio, allowing the detection of temperature differences as small as 0.05 K. Regarding pressure sensing, the sensitivity exhibited in the low‐pressure range (0–4 kPa) is −11.44% kPa−1. Additionally, MXene significantly increases the sensor's electrical conductivity, reducing electron scattering and obstacles, shortening the response and recovery times (120 ms) for pressure measurements, and combining with CNTs/CNF increasing the hardness of the PCCM sensor, thereby expanding the pressure measurement range (0–20 kPa). It also highlights its promising potential for skin‐like sensing and human–computer interaction applications by developing a multimodal intellectual panel. This work provides a simple and scalable fabrication method to design high‐performance multifunctional sensors for various applications, such as e‐skin and robotics.
Nucleation and Growth of Blue Phase 3D Cubic Structure Under Continuously Changing Curved Boundary Conditions
Authors: Wang Xiaowei , Pawale Tejal , Swain Justin , Czaplewski David A. , Divan Ralu Nana Silvia , Tierra Giordano , Li Xiao 
Published: February 2025

AbstractThe blue phase of liquid crystals (BPLCs) with a cubic lattice of disclination lines and 3D nanostructure enables the modulation of photonic bandgap thus casting them in the category of photonic crystals. Its unique nature promises applications in display technologies, electro‐optics, and sensors. To integrate these ordered materials into wearable devices a fundamental understanding of curvature, and spatial confinement is necessary. Although continuous confinement in flat geometries have been studied, confining curvature has shown to induce strong destabilization effects on the cubic structure and formation of topological defects, thereby deteriorating their optical performance. Moreover, limitations in controlling the curvature of droplets further hinder studies of nucleation and growth of BPLCs. To address these challenges, micro‐scale patterned surfaces of concentric cylinders are exploited to systematically control curvatures. The impact of curvature on the confined BPLCs is revealed in terms of phase transition temperature, nucleation and growth, morphology, as well as phase transformation. This research offers valuable insights into the stability, and structural characteristics of BPLCs in adaptive photonic devices, paving the way for future advancements in flexible displays, sensors, and other technologies leveraging liquid crystal (LC) materials.
Bio‐Inspired Multifunctional Smart Windows: Surface Wrinkle‐Crack for Dynamic Optical and Wettability Modulations
Authors: Zhang Qiuting , Zhu Tingting , Li Na , Hu Yuwei , Xu Ye , Chen Xi , Long Yi , Ke Yujie 
Published: February 2025

AbstractSmart windows are promising to promote building energy efficiency. Bio‐inspired smart windows are expected to fulfill the independent energy‐saving and on‐demand privacy modes simultaneously, while further improvement is necessary. Here, an improved composite based on tungsten‐doped vanadium dioxides (W‐VO2), silica (SiO2) nanospheres, and polydimethylsiloxane (PDMS) elastomers is reported. It is found that the composite can simultaneously fulfill the on‐demand privacy and energy‐saving modes under a low temperature of ≈45 °C. More importantly, the surface morphology effects are investigated on optical and wettability modulation and provide insight into the SiO2‐based wrinkle formation mechanisms. It is demonstrated that surface wrinkles are more effective than cracks in achieving privacy mode, indicated by the diffraction patterns. Increasing the surface wrinkles and cracks also causes a change from hydrophilic to hydrophobic properties accompanied by the contact angle change from 19° to 115°, suggesting the potential for self‐cleaning functionality. It is also demonstrated that SiO₂ spheres are essential in forming wrinkles: small gaps between nearby SiO₂ spheres promote localized strain and increase the overall Young's modulus, resulting in larger wrinkle amplitude. Combining the improved method and insight understanding, this work is expected to support future developments in mechano‐/thermos‐chromic materials, smart windows, and bioinspired optical materials designs.
Boosting Hydrogen Evolution on MoS2/N‐doped‐C Nanotubes via Integrated Van der Waals Engineering and Morphology Engineering
Authors: Feng Sizhuo , Wang Fengshun , Gu Chen , Chen Jianmei , Liu Shujuan , Wang Longlu , Zhao Qiang 
Published: February 2025

AbstractIn the realm of electrocatalytic hydrogen evolution reaction (HER), molybdenum disulfide (MoS2) is a material that holds great promise as a substitute for platinum (Pt), which is both expensive and scarce. The restricted number of active sites and low conductivity of MoS2 have an impact on its catalytic efficiency, however, which hampers the application of MoS2‐based catalysts in practical catalytic hydrogen production. The integrated Van der Waals (vdW) engineering and morphology engineering hold the potential to effectively boost hydrogen evolution on MoS2. Herein, hierarchical nanotubes (MoS2/N‐doped‐C) assembled from MoS2 nanosheets sandwiched by N‐doped‐C layers are synthesized utilizing an integration of hydrothermal and annealing. The 3D hierarchical structure with stepped edges, produced by directly integrating carbon layers into the MoS2 interlayers, enhances the catalytic activity and stability of the HER compared to MoS2 scattered on conductive carriers. The experimental results demonstrate that MoS2/N‐doped‐C shows excellent electrocatalytic HER activity under acidic conditions, exhibiting an extremely small Tafel slope of 42 mV dec−1, an extremely low overpotential of 41 mV at a geometric current density of 10 mA cm−2, and maintaining durability for more than 100 h.
Boosting the Efficiency and Mechanical Stability of Organic Solar Cells Through a Polymer Acceptor by Reducing the Elastic Modulus
Authors: Wang Yan , Yu Han , Zhao Dan , Liu Wei , Liu Baoze , Wu Xin , Gao Danpeng , Zhang Dong , Zhang Shoufeng , Sun Xianglang , Zhang Chunlei , Zhao Chaoyue , Fu Yuchen , Song Wei , Gong Shaokuan , Fu Yuang , Kwok Chung Hang , Ge Ziyi , Lu Xinhui , Chen Xihan , Xiao Shuang , Wong Wai‐Yeung , Chai Yu , Yan He , Zhu Zonglong 
Published: February 2025

AbstractOrganic solar cells (OSCs) are regarded as one of the most promising flexible power sources due to their lightweight and flexible properties, with the improvement of photovoltaic and mechanical performance. To improve the current density and power conversion efficiency (PCE), mPh4F‐TS (TS) and PYSe2F‐T (PA) are introduced into the binary host, PM6/mPh4F‐TT (PM6/TT) as third components. It is demonstrated that the corresponding ternary devices, in both rigid and flexible devices, achieved superior efficiencies (19.6%/17.7% for PM6/TT+TS, and 19.2%/17.4% for PM6/TT+PA) outperform the binary counterparts (18.3%/16.4%). However, distinct differences in mechanical performance are observed between the polymer acceptor (PA) and small‐molecular acceptor (TS). The PM6/TT+PA significantly improved the mechanical stability of flexible devices with a lower elastic modulus of 3.6 GPa, while the PM6/TT+TS resulted in the opposite effect with a higher elastic modulus of 5.5 GPa. Through in‐depth investigation, a clear correlation between the elastic modulus, crack density, and mechanical stability of the active layer blends is successfully established, revealing the key role of reducing the elastic modulus in enhancing the mechanical stability of flexible OSCs. This study provides important guidance for the development of flexible photovoltaic devices with both high efficiency and mechanical robustness.
Metal−Organic Framework with Constrained Flexibility for Benchmark Separation of Hexane Isomers
Authors: Wen Kuishan , Zhou Jingyi , Ke Tian , Li Jinjian , Jin Yuanyuan , Zhang Qianglong , Zhang Zhiguo , Bao Zongbi , Ren Qilong , Yang Qiwei 
Published: February 2025

AbstractFlexible metal−organic frameworks (MOFs) are promising candidates for adsorptive separations, but achieving a balance among flexibility, adsorption capacity, and selectivity remains challenging. Herein, we report a novel flexible MOF, Ni(bhdc)(ted)0.5 (ZUL−C6), incorporating hybrid three‐dimensional alkane‐bridged ligands, which realizes high‐capacity molecular sieving for hexane isomer separation ‐ a critical process in the petroleum industry. The alkyl‐rich, confined pore system within the ZUL−C6 framework facilitated a strong affinity for n‐hexane and 3‐methylpentane. However, the narrow pore size and the constrained flexibility limited the uptake of 2,2‐dimethylbutane (<4.0 mg/g), accompanied by a high gate‐opening pressure. The gating behavior was elucidated by guest‐loaded single‐crystal (SC) X‐ray diffraction and density functional theory (DFT) simulations, which revealed a unique SC to SC transformation driven by the non‐centrosymmetric rotation of the 3D bhdc linker and distortion of the metal cluster and pillar units, along with a high deformation energy barrier. As a result, ZUL−C6 exhibited not only significantly higher uptake and selectivity than the industrially used 5 A molecular sieve, but also the record‐high nHEX/3MP breakthrough uptake (92.8/73.9 mg/g) and unprecedented 22DMB producing time (309.2 min/g, corresponding to the productivity of 770 mmol/kg and yield of 92.8 %) among reported MOFs.
Combining the Folch method with a simplified alternative fat extraction technique for use in a colorimetric assay to measure the degree of unsaturation in fat samples in a biochemistry laboratory
Authors: Pragash Vimoshini , Ediriweera Meran Keshawa 
Published: February 2025

AbstractThe Folch method is a commonly employed, simple biochemical procedure used to extract fat from food items and biological samples in biochemistry laboratories. The iodine number of fat reflects its degree of unsaturation. In the present study, the iodine number of fat extracted using the Folch method from cow milk, goat milk, chicken egg yolk and coconut milk was determined using a simple colorimetric procedure that comprises an iodine solution in ethanol and a starch solution, replacing the Wijs reagent and conventional titration procedures with sodium thiosulfate standard solutions. Resembling the Folch method, a low‐cost alternative approach, utilizing kerosene oil, isopropyl alcohol, and water, which can be used to extract fat from commonly consumed liquid food items, was also developed in the present study as a simple and reliable approach. The extracted fat from the proposed method can be sent to a biochemistry laboratory to determine the iodine number using the proposed 96‐well plate‐based colorimetric procedure. The proposed methods are suitable for laboratories in low‐income settings.
A Phase IB Trial of Selinexor in Combination With Immune Checkpoint Blockade in Patients With Advanced Renal Cell Carcinoma
Authors: Alhalabi Omar , Gouda Mohamed A. , Milton Denái R. , Momin Hassan Ahmed , Yilmaz Bulent , Stephen Bettzy , Ejezie Chinenye Lynette , Moyers Justin Tyler , Gurses Serdar A. , How Jeffrey , Fu Siqing , Rodon Jordi , Hong David S. , Piha‐Paul Sarina A. , Subbiah Vivek , Elena Dumbrava Ecaterina , Karp Daniel D. , Janku Filip , Meric‐Bernstam Funda , Tannir Nizar M. , Naing Aung 
Published: February 2025

ABSTRACTBackgroundSelinexor (SEL) is a nuclear exportin 1 inhibitor that blocks the transport of nuclear proteins, including tumor suppressors, to the cytoplasm. Preclinical data suggest that the combination of SEL with checkpoint blockade may result in improved response to immunotherapy.MethodsNCT02419495 was a multiarm phase IB study of SEL in combination with other standard regimens in patients with advanced malignancies. Arm M utilized twice weekly oral SEL and intravenous nivolumab (NIVO). Arm N utilized weekly oral SEL with NIVO plus ipilimumab (IPI). The primary objective of this study was to evaluate the safety of SEL + NIVO and SEL + NIVO+IPI. Secondary objectives included determining the objective response rate (ORR) and progression‐free survival (PFS).ResultsTwenty‐nine patients were enrolled in the study, of which 26 (90%) had clear cell RCC (ccRCC). Most patients (72%, n = 21) had prior systemic therapies. All patients (100%) developed at least one treatment‐emergent adverse event, and 93% had a treatment‐related adverse event (TRAE). Grade ≥ 3 TRAE occurred in 31% of patients, including 10% with hyponatremia, 7% with neutropenia, and 7% with thromboembolic events. At a median follow‐up of 12.4 months, the ORR in 27 patients evaluable for response was 19% (n = 5). An additional 17 patients (63%) had stable disease (SD) as the best response. The median PFS for the overall cohort was 14.5 months (95% CI 5.2–17.4 months; SEL + NIVO+IPI: 12.2 months, SEL + NIVO: 14.5 months). The median overall survival was 27.8 months (95% CI 15.3–32.5; SEL + NIVO+IPI: unreached, SEL + NIVO: 21.3 months).ConclusionsSEL in combination with NIVO or NIVO+IPI had a potentially favorable safety profile and showed modest clinical activity in patients with advanced renal cell carcinoma.Trial Registration: This clinical trial was registered on clinicaltrials.gov (NCT02419495)
Maintenance therapy with the FMS‐like tyrosine kinase 3 inhibitor gilteritinib in patients with FMS‐like tyrosine kinase 3–internal tandem duplication acute myeloid leukemia: A phase 2 study
Authors: Gyan Emmanuel , Minden Mark D. , Kubo Kohmei , Rambaldi Alessandro , Juliusson Gunnar , Jädersten Martin , Kelly Richard J. , Szerafin László , He Wensheng , Gill Stanley C. , Hill Jason E. , Chen Caroline , Delgado David , Hasabou Nahla 
Published: February 2025

AbstractBackgroundThe GOSSAMER phase 2 study assessed the FMS‐like tyrosine kinase 3 (FLT3) inhibitor gilteritinib as maintenance therapy in patients with FLT3–internal tandem duplication (FLT3‐ITD) acute myeloid leukemia (AML) in first complete remission without previous hematopoietic stem cell transplantation (HSCT).MethodsPatients had to be within 2 months of their last consolidation cycle and have completed the recommended number of cycles per local practice. FLT3 inhibitors were allowed only during induction and/or consolidation. The primary end point was relapse‐free survival (RFS). Secondary end points included overall survival (OS), event‐free survival, and measurable residual disease (MRD).ResultsIn total, 98 patients were randomized (gilteritinib, n = 63; placebo, n = 35). RFS was not significantly different between the arms (hazard ratio, 0.74; 95% confidence interval, 0.41–1.34; p = .16). RFS rates for the gilteritinib and placebo arms were 68.5% and 55.3% at 1 year, 51.8% and 44.9% at 2 years, and 41.2% and 40.8% at 3 years, respectively. OS was not significantly different between the arms but may have been affected by subsequent AML therapies after discontinuation. In patients who received subsequent therapy (gilteritinib, 46.8%; placebo, 60.0%), a higher percentage of placebo‐treated (57.1%) versus gilteritinib‐treated patients (27.6%) underwent HSCT. At the end of treatment, 96.4% of gilteritinib‐treated and 85.7% of placebo‐treated patients had undetectable MRD. Relapsed placebo‐treated (86.7%) versus gilteritinib‐treated patients (34.8%) had a greater FLT3 mutational burden. No new significant safety concerns were noted.ConclusionsThe primary end point was not achieved; however, an observed trend toward potential benefit was noted in patients with FLT3‐ITD AML who had not undergone prior HSCT.
Unraveling the Curcumin's Molecular Targets and Its Potential in Suppressing Skin Inflammation Using Network Pharmacology and In Vitro Studies
Authors: Sureshbabu Anjana , Smirnova Elena , Tuong Do Thi Cat , Vinod Sangeetha , Chin Sungyeon , Moniruzzaman Mohammad , Senthil Kalaiselvi , Lee Dong I. , Adhimoolam Karthikeyan , Min Taesun 
Published: February 2025

ABSTRACTCurcumin, a polyphenol compound derived from turmeric, has garnered attention for its anti‐inflammatory and antioxidant properties, making it a promising candidate for treating skin inflammation. Despite its potential, the underlying pharmacological effects to skin inflammation remain unclear. Therefore, this study aimed to reveal the curcumin's molecular targets and its potential in suppressing skin inflammation using network pharmacology and in vitro experiments. A total of 7,393 and 239 targets related to curcumin and skin inflammation, respectively, were obtained from public databases. By drawing a Venn diagram, 216 common targets were identified as candidate targets. These targets were subjected to gene function and pathway enrichment analyses, and a protein‐protein interaction network was established to investigate curcumin's impact on inflammation. The gene functions were mainly associated with inflammatory response, membrane raft, and serine‐type endopeptidase activity. The NF‐κB and MAPK pathways could be the major pathways through which curcumin acts on skin inflammation. Ten major targets of curcumin in the treatment of skin inflammation were identified: AKT1, TNF, EGFR, APP, MMP9, STAT3, HIF1A, PTGS2, EP300, and GSK3B. Molecular docking analysis results showed high binding affinity of curcumin to PTGS2, GSK3B, HIF1A, and STAT3, which may contribute to its inhibitory effect on skin inflammation. In vitro experiments confirmed curcumin's anti‐inflammatory effect on inflammation by reducing the expression levels of NO, IL‐1β, and IL‐6 in LPS‐induced HaCaT cells. Taken together, this study reveals major targets and pathways of curcumin in the treatment of skin inflammation, paving the way for invivo and clinical investigations.
In Vitro and In Silico Assessment of Antileishmanial Potential of Novel Tri‐ and Penta‐Valent Antimony Complexes With Phenolic Ligands
Authors: Shehzadi Syeda Aaliya , Ahmed Faiz , Islam Arshad , Ahmed Zeshan , Abdullah Khizar , Younas Farhan , Haider Ali , Tariq Muhammad , Noureldeen Ahmed , Albogami Bander , Darwish Hadeer , Alajmi Fatemah Enad M. 
Published: February 2025

ABSTRACTLeishmaniasis, caused by protozoan parasites of the genus Leishmania, affects nearly 12 million people annually worldwide, and has limited, highly toxic therapeutic options. This study reports the synthesis, in vitro and in silico evaluations of four novel antimony complexes (3a‐3d) as potent and safe antileishmanial agents. The complexes were synthesized using Sb‐salts with different phenolic ligands and characterized by elemental analysis, FT‐IR and NMR spectroscopic techniques. Structural parameters were further evaluated via DFT studies. The antileishmanial activity of these complexes (3a‐3d) was assessed in vitro against promastigote and axenic amastigote forms of Leishmania tropica, showing promising potential as antileishmanial agents. Complex 3a and 3c were particularly active, with IC50 values of 10.8 ± 2.1 and 11.0 ± 2.0 μmol/L against promastigotes, and 20.14 ± 6.11 and 27.72 ± 0.13 μmol/L against amastigotes, respectively. Molecular docking analysis against receptor protein (PDB ID: 8FI6) from genus Leishmania revealed high binding conformations of synthesized molecules within the active cavity of the target protein. With the lowest Ki value of 1.25 and a pattern of hydrophobic π‐interactions and strong conventional hydrogen bonds, complex 3d demonstrated excellent binding affinities within the active pocket. Notably, these complexes exhibited low cytotoxicity, compared to the standard antileishmanial drugs, TA (potassium antimonyl tartrate) and AmB (Amphotericin B), with hemolysis rates of < 12% for all complexes. Our findings suggest that these complexes (3a‐3d) are promising candidates for the development of new, safer antileishmanial therapies, combining potent activity against L. tropica with significantly lower cytotoxicity compared to existing treatments.
Functional Reproductive and Developmental Traits Differences Between Two Macrocystis Ecomorphs: Importance of Neutral Lipids
Authors: Rodríguez‐Villegas Camilo , Buschmann Alejandro H. , Barrios Mayra A. , Pereda Sandra , Camus Carolina , Fernández Pamela , Hérnandez‐González María C. , Baldrich Ángela M. , Urrutia Cynthia , Poza Ailen M. , Villegas Karina , Martínez Camila , Vargas Jaime 
Published: February 2025

ABSTRACTThe kelp genus Macrocystis presents populations recognizable by distinct morphological traits, which has raised discussions on its taxonomical status. Recently, whole genome sequencing arose global evidence of Macrocystis ecomorphs “integrifolia” and “pyrifera” being genetically distinct. In the southern hemisphere, both ecomorphs maintain a separated distribution that coincides, without overlap, in the area of 33° S. Besides the fact that both ecomorphs are interfertile, at least under laboratory conditions, several differences in their reproductive strategies and early developmental traits have arisen in over 20 years of ecological and ecophysiological studies. In this study, we evaluated the content of neutral lipids in zoospores of both ecomorphs as a proxy of the required energy to swim and settle. The finding showed that zoospores of “integrifolia” ecomorph have a significantly lower level of neutral lipids than the southern “pyrifera” ecomorph. This correlates with the lower motility of the cells and lower germination capacity in the ‘integrifolia’ ecomorph, which has been consistently seen over the years. Further, we have seen a highly consistent pattern of a higher zoospore production, germination rate, sexual reproductive success, and early developmental performance (growth and survival) of juvenile sporophytes of “pyrifera” compared to “integrifolia.” Hence, both ecomorphs show, in addition to genetic and morphological differences, differential reproductive functional traits consistent in time and space that further support the hypothesis of an ongoing separation of these two Macrocystis ecomorphs.
Intake of High‐Calorie Diet and Phytonutrients: A New Paradigm to Treat Cerebral Palsy in Children
Authors: Tufail Tabussam , Ain Huma Bader Ul , Mahwish  , Noreen Sana , Ijaz Aiman , Ikram Ali , Arshad Muhammad Tayyab , Abdullahi Muhammed Adem 
Published: February 2025

ABSTRACTCerebral palsy (CP) encompasses neurodevelopmental disorders affecting movement and posture, arising from nonprogressive brain damage during prenatal, perinatal, or postnatal periods. Diagnosis typically occurs between ages 3 and 5, with symptoms including abnormal muscle tone and impaired motor skills. CP's etiology is diverse, ranging from genetic predispositions to perinatal complications, often exacerbated by poor nutrition. Management requires a multidisciplinary approach involving neurologists, therapists, surgeons, psychologists, and social workers to address motor impairments and co‐morbidities like epilepsy, cognitive deficits, and sensory impairments. Neurological rehabilitation, primarily through physical and occupational therapies, forms the cornerstone of CP management. Addressing feeding difficulties, common in CP, often necessitates enteral or parenteral feeding, each with potential complications. High‐calorie formulas offer a promising strategy to combat undernutrition and improve motor outcomes. Research also explores the potential benefits of natural compounds like kaempferol and resveratrol, though further investigation is needed.