bluuebunny/crossref_metadata_2025_split huggingface dataset:
INVERTEBRATE DIVERSITY FROM DEEP WELLS OF THE SOUTHERN BOUNDARY OF THE EDWARDS AQUIFER OF SOUTH-CENTRAL TEXAS
Authors: Perez Kathryn E. , Cantu Valentin , Saenz Vanessa , Gibson J. Randy , Duncan Patricia , Hutchins Benjamin 
Published: June 2024

Abstract
This study examined the invertebrate fauna from three deep wells located at the Uvalde National Fish Hatchery in south-central Texas. These wells provide a water source from geological strata of the southern boundary of the Edwards Aquifer ranging in age from Lower Cretaceous to Recent. Forty-seven collections, sampled on a continuous basis from November 2020 to January 2022, produced a total of 738 specimens comprising 15 different species. These collections reveal a diverse crustacean assemblage along with dominant numbers of the stygobiotic snail Balconorbis uvaldensis. This study provides a preliminary survey for future investigations of unidentified crustacean species as well as revealing seasonal variations in the reproductive life cycle of Balconorbis uvaldensis.
Study of Problems Involving Mobile Agents
Authors: Kundu Somnath 
Published: June 2024

<p>In this thesis we study two different problems that involve the movement of some entities within a well-defined space. One problem is in a continuous domain and the other problem is in the context of discrete spaces of graphs. </p>
<p>The first problem is a primitive vehicle routing-type problem in which a fleet of n ∈ {1, 2, 3} unit speed robots start from a point within a non-obtuse triangle ∆, where the goal is to design robots’ trajectories to visit all edges of the triangle with the smallest visitation time makespan. Here, makespan is defined as the maximum of the times needed by each robot to finish the work. We begin our study by introducing a framework for subdividing ∆ into regions with respect to the type of optimal trajectories that each starting point P ∈ ∆ admits, pertaining to the order that edges are visited and to how the cost of the minimum makespan Rn(P) is determined, for n ∈ {1, 2, 3}. These subdivisions lead to our main result, which involves makespan trade-offs with respect to the size of the fleet. </p>
<p>In the next problem we study unit acquisition process in the context of random graphs. Here each vertex of a given graph has unit weight initially. In each step, the unit weight from a vertex u to a neighbouring vertex v can be moved, provided that the weight on v is at least as large as the weight on u. The unit acquisition number of graph G, denoted by au(G), is the minimum cardinality of the set of vertices with positive weight at the end of the process, over all acquisition algorithms. We investigate the Erdõs-Rényi random graph process and show that asymptotically almost surely au(G) = 1 when the random graph process creates a connected graph. The result holds in the strongest possible sense, since au(G) ≥ 2 if the graph is disconnected.</p>
Tiedostavan ajattelun seurauksena tapahtuva taloudellinen vapautuminen
Authors: Niukko Kirsi , Viitasalo Katri 
Published: June 2024

Moni taloudellisesti heikkoon asemaan joutunut ihminen tarvitsee tukea talousvaikeuksista selviytymiseen, velkaantuneisuudesta ja vähävaraisuudesta irti pääsemiseen ja saavuttaakseen taloudellisen itsenäisen elämän. Sosiaalipalveluissa on totuttu tukemaan avunhakijoita rahansiirtoina toteutettavan toimeentulotuen keinoin, mutta taloudellisen emansipaation näkökulma on uusi.
Tarkastelemme taloudellista voimaantumista talousvaikeuksiin joutuneiden sosiaalityön asiakkaiden kertomana. Tutkimus toteutuu kriittiseen realismiin pohjautuvassa teoreettisessa viitekehyksessä. Kysymme, kuinka taloudellisen tiedostamisen transformaatiomalli jäsentää asiakas- ja työntekijäsuhteen välisessä dialogissa tapahtuvaa muutosta.
Tutkimusaineisto koostuu sosiaalityön asiakkaiden (N = 12) haastatteluista, jotka analysoimme dialektiseen kriittiseen realismiin perustuvaa muutosvaihemallia hyödyntäen. Taloudellisen tiedostamisen herääminen on monitasoinen prosessi, joka rakentuu sekä asiakkaan sisäisessä muutosprosessissa että asiakkaan ja ammattilaisen välisessä dialogissa. Dialogissa on olennaista talousvaikeuksien tunnistaminen monin eri tavoin ilmenevinä hyvinvointirajoitteina, kuten puheena, stigmana tai terveydellisinä ongelmina. Vuorovaikutussuhteen tulee perustua luottamuksellisuuteen ja käytännön tukeen arkisten taloustaitojen harjoittelussa.
Sisäinen muutosprosessi perustuu tiedostavan ajattelun heräämiseen, jolloin ihminen kokee itsensä omaa taloudellista elämäänsä koskevien ratkaisujen subjektiksi. Oikea-aikainen tuki herättää tiedostavan ajattelun ja johtaa parhaimmillaan emansipaatioon ja taloudellisesti itsenäiseen elämään.
The Examples of Personal and Household Financial Planning and Management in Improving Prosperity
Authors: Tarigan Lukas 
Published: June 2024

We often do not plan and manage the use of personal funds households funds. As a result of this, many people complain about finances. This study is a type of literature research study, by looking for reference theory relevant to the problem found. The type of data used by the author is primary data through observation and secondary data. Actually, although our income is small, if we planned and managed well, then it will result in a better level of welfare.
Keywords: Financial Planning, Personal Management, Prosperity
The ANALYSIS OF FACTORS INFLUENCING STUDENTS FOR CHOOSING BACHELORâ€™S IN ACCOUNTING PROGRAM AT FACULTY OF ECONOMY AND BUSINESS, CHRISTIAN UNIVERSITY OF INDONESIA
Authors: Sembiring Carolina F. , Sidharta Juaniva , Simanjuntak Ramot P. 
Published: June 2024

FEB UKI experienced the problem of fluctuating the number of students who should be addressed by improving the quality of service through improving the quality of human resources in UKI, so that it would have an impact on the interest of prospective new students to choose FEB UKI and ultimately influence their level of satisfaction. Therefore, it is necessary to know what factors influence students choosing to study at the FEB UKI Accounting Undergraduate study program. The results showed that 1) Factors influencing old students choosing yo study in the S-1 Accounting Study Program FEB UKI were factors 1 such as person variables, physical evidence, prosesses, products and costs, while factor 2 such as reference group variables, self and family desires. 2) Factors influencing new students choosing to study at the S-1 Accounting Study Program FEB UKI are factors 1 such as cost variable, own desire, person, promotion, group references, and process, while factor 2 is product variable, physical evidence, and family.
Keywords: Factor influencing students for choosing Accounting Undergraduate Program, Factor Analysis, Confirmatory Factor Analysis.
MARKETING STRATEGY ANALYSIS CV. NAVALE MITRATAMA USING SWOT METHOD TO IMPROVE COMPETITIVENESS
Authors: Monica Nita Thalia Monica , Panjaitan Robert Panjaitan , Sihombing Christina N. 
Published: June 2024

This Research aims to find out and analyze SWOT strengths, weaknesses, opportunities, threats as CV Navale Mitratama’s marketing strategy using SWOT methods to improve competitiveness. The study is done in may 2020 at CV Navale Mitratama. The hypothesis presented was an analysis of CV Navale Mitratama’s marketing strategy using SWOT methods to improve competitiveness.
This research uses a qualitative type of descriptive research. This data is collected through the primary data, and it is analyzed using qualitative descriptive methods of anaanalyzing by using the internal and external swot matrix. The result of swot analysis research have subsequently been a basic refrence to CV Navale Mitratama’s marketing strategies .
Keywords: swot analysis, marketing strategies and competitiveness.
EFFECT OF IGNITION TIMING CHANGES ON EXHAUST EMISSIONS IN KEN AROK URBAN CAR FUELED BY ETHANOL E100
Authors: Herda Herda Bimantara 
Published: June 2024

ABSTRACT
The depletion of fossil fuel reserves, as well as the increasing air pollution that occurs in Indonesia, greatly affects the energy crisis. This study aims to test, analyze, and determine the right ignition timing and injection timing so as to reduce HC and CO exhaust emissions pollution with E100 ethanol fuel. The test method in this study uses ignition timing independent variables (10.5⁰, 12.5⁰, 14.5⁰, 16.5⁰) and is carried out at 1500, 2000, 3000, 4000 RPM engine speed. The results of this study can be seen that the ignition timing variable has an influence on HC and CO exhaust emissions. at 1500 RPM rotation, the lowest HC and CO exhaust emissions are obtained at 16.5⁰ ignition timing with a value of HC 260 ppm and CO 0.12%. Then for the highest exhaust gas results there is at 12.5⁰ ignition timing with a value of HC 310 ppm and CO 0.16%.

Keywords: exhaust emissions, ethanol, ignition timing
Apakah Teori Agensi Belum Diterapkan Secara maksimal pada Bank BUMN?
Authors: Nurmuzakki Naufal , Mulawarman Aji Dedi 
Published: June 2024

Abstract: Has Agency Theory Not Been Applied Maximally in State-Owned Banks?Purpose: To determine the impact of Capital Adequacy Ratio (CAR), Non-performing Loans (NPL), and Loan to Deposit Ratio (LDR) on Return on Assets (ROA). Method: Using multiple regression analysis in 4 state-owned bank Indonesia at 2004-2022.Results: CAR has no effect on ROA while NPL and LDR have a significant negative effect on ROA. Simultaneously CAR, NPL, LDR have a significant effect on ROA.Novelty: This research support signaling theory but doesn't support the agency theory because state-owned banks management in Indonesia only giving positive signal to investor by nonperforming loan ratio and loan to deposit ratio. Contribution: This research suggest that management need to act more professionally by considering capital adequacy and not only focusing on nonperforming loan and liquidity.
Abstrak: Apakah Teori Agensi Belum Diterapkan Secara maksimal Pada Bank BUMN?Tujuan: Untuk mengetahui pengaruh Capital Adequacy Ratio (CAR), Non-performing Loan (NPL), dan Loan to Deposit Ratio (LDR) terhadap Return on Aset (ROA).Metode: Menggunakan analisis regresi berganda dengan 4 Bank BUMN di Indonesia selama 2004-2022.Hasil: CAR tidak berpengaruh terhadap ROA sementara NPL dan LDR memiliki pengaruh negatif yang signifikan terhadap ROA dan secara simultan CAR, NPL, dan LDR berpengaruh terhadap ROA.Kebaruan: Penelitian ini mendukung teori sinyal dan belum dapat mendukung teori agensi karena kecukupan modal bukan menjadi pertimbangan manajemen Bank BUMN karena mereka hanya mempertimbangkan sinyal positif kepada para investor melalui tingkat kredit macet serta likuiditas.Kontribusi: Penelitian ini menyarankan kepada manajemen bank agar lebih bersikap professional dengan mempertimbangkan kecukupan modal dan tidak hanya berfokus pada kredit macet serta likuiditas.
A comprehensive multi-omics analysis reveals unique signatures to predict Alzheimer’s disease
Authors: Vacher Michael , Canovas Rodrigo , Laws Simon M. , Doecke James D. 
Published: June 2024

BackgroundComplex disorders, such as Alzheimer’s disease (AD), result from the combined influence of multiple biological and environmental factors. The integration of high-throughput data from multiple omics platforms can provide system overviews, improving our understanding of complex biological processes underlying human disease. In this study, integrated data from four omics platforms were used to characterise biological signatures of AD.MethodThe study cohort consists of 455 participants (Control:148, Cases:307) from the Religious Orders Study and Memory and Aging Project (ROSMAP). Genotype (SNP), methylation (CpG), RNA and proteomics data were collected, quality-controlled and pre-processed (SNP = 130; CpG = 83; RNA = 91; Proteomics = 119). Using a diagnosis of Mild Cognitive Impairment (MCI)/AD combined as the target phenotype, we first used Partial Least Squares Regression as an unsupervised classification framework to assess the prediction capabilities for each omics dataset individually. We then used a variation of the sparse generalized canonical correlation analysis (sGCCA) to assess predictions of the combined datasets and identify multi-omics signatures characterising each group of participants.ResultsAnalysing datasets individually we found methylation data provided the best predictions with an accuracy of 0.63 (95%CI = [0.54–0.71]), followed by RNA, 0.61 (95%CI = [0.52–0.69]), SNP, 0.59 (95%CI = [0.51–0.68]) and proteomics, 0.58 (95%CI = [0.51–0.67]). After integration of the four datasets, predictions were dramatically improved with a resulting accuracy of 0.95 (95% CI = [0.89–0.98]).ConclusionThe integration of data from multiple platforms is a powerful approach to explore biological systems and better characterise the biological signatures of AD. The results suggest that integrative methods can identify biomarker panels with improved predictive performance compared to individual platforms alone. Further validation in independent cohorts is required to validate and refine the results presented in this study.
Epidemiological investigation on diseases of Larimichthys crocea in Ningbo culture area
Authors: Xu Shengwei , Ge Mingfeng , Feng Juan , Wei Xinxian , Tan Honglian , Liang Zheng , Tong Guixiang 
Published: June 2024

IntroductionDue to the high-density farming of Larimichthys crocea over the years, diseases caused by pathogens such as bacteria, viruses, and parasites frequently occur in Ningbo, posing a huge threat and challenge to the sustainable and healthy development of the L. crocea’s bay farming industry. In order to understand the diseases occurrence in L. crocea farming in Ningbo area, an epidemiological investigation of L. crocea diseases was carried out through regular sampling in 2023. MethodsFrom April to October 2023, routine sampling of L. crocea was conducted monthly in various farming areas in Ningbo. Each time, live or dying L. crocea with obvious clinical symptoms were sampled, with a total number of 55 L. crocea collected. The samples were preserved in ice bags and transported to the laboratory for pathogen detection(including bacterial isolation and identification,virus identification, and parasites detection).ResultsA total of fifty-five fish dying L. crocea with obvious clinical symptoms were collected in this study, of which 78.18% (43/55) were detected with symptoms caused by pathogenic infection, while 21.82% (12/55) did not have identified pathogens, which were presumed to be breeding abrasions, nutritional metabolic disorders, unconventional pathogens infection or other reasons. A total of twenty-five pathogenic bacteria strains were isolated, which mainly were Pseudomonas plecoglossicida and Vibrio harveyi, accounting for 52% (13/25) and 32% (8/25) of the pathogenic bacteria strains, respectively. Among them, both V. harveyi and Streptococcus. iniae co-infected one fish. Additionally, three other bacterial strains including Nocardia seriolae, Staphylococcus Saprophyticus, and Photobacterium damselae subsp.damselae were isolated. Microscopic examination mainly observed two parasites, Cryptocaryon irritans and Neobenedenia girellae. In virus detection, the red sea bream iridovirus (RSIV) was mainly detected in L. crocea. Statistical analysis showed that among the fish with detected pathogens, 55.81% (24/43) had bacterial infections, 37.21% (16/43) had parasitic infections, and 37.21% (16/43) had RSIV infections. Among them, five fish had mixed infections of bacteria and parasites, three had mixed infections of bacteria and viruses, three had mixed infections of parasites and viruses, and one L. crocea had mixed infections of viruses, bacteria, and parasites. DiscussionThese findings indicate that these three major types of diseases are very common in the L. crocea farming area in Ningbo, implying the complexity of mixed infections of multiple diseases.
Clinical characteristics and outcomes of persistent bacteremia in patients with head and neck cancer in a tertiary care hospital
Authors: Kitaya Shiori , Kanamori Hajime , Ishii Ryo , Katsumi Makoto , Ikeda Ryoukichi , Higashi Kenjiro , Kakuta Risako , Ohkoshi Akira , Katori Yukio 
Published: June 2024

IntroductionCompared to other cancers, research on bloodstream infection in head and neck cancer is scarce, lacking comparative studies on persistent versus transient bacteremia outcomes.MethodsThis retrospective survey examined patients with head and neck cancer undergoing blood culture at our center from June 2009 to May 2023. Blood culture-positive cases suspected of infection were divided into persistent bacteremia and transient bacteremia groups. We investigated their clinical, epidemiological, and microbiological features, including risk factors for persistent bacteremia and mortality. The primary outcome was 90-day mortality.ResultsIn this 97-patient cohort, 14 (14%) cases were assigned to the persistent bacteremia group. Catheter-related bloodstream infections were the leading cause of infection in both groups, consistently contributing to a high proportion of overall bloodstream infections. The mortality rate was generally higher in the persistent bacteremia group than in the transient bacteremia group (odds ratio [OR], 2.6; 95% confidence interval [CI], 0.6–11.1), particularly in the non-clearance subgroup (OR, 9; 95% CI, 0.5–155.2). Pyogenic spondylitis was a key risk factor for persistent bacteremia, while hypoalbuminemia increased mortality.ConclusionIn patients with bacteremia and head and neck cancer, persistent bacteremia was associated with higher mortality than was transient bacteremia. Adittionally, bacteremia clearance in persistent bacteremia is thus crucial for prognostic improvement.
Comprehensive characterization of γ-aminobutyric acid (GABA) production by Levilactobacillus brevis CRL 2013: insights from physiology, genomics, and proteomics
Authors: Cataldo Pablo G. , Urquiza Martínez María Paulina , Villena Julio , Kitazawa Haruki , Saavedra Lucila , Hebert Elvira M. 
Published: June 2024

IntroductionLevilactobacillus brevis CRL 2013, a plant-derived lactic acid bacterium (LAB) with immunomodulatory properties, has emerged as an efficient producer of γ-aminobutyric acid (GABA). Notably, not all LAB possess the ability to produce GABA, highlighting the importance of specific genetic and environmental conditions for GABA synthesis. This study aimed to elucidate the intriguing GABA-producing machinery of L. brevis CRL 2013 and support its potential for safe application through comprehensive genome analysis.MethodsA comprehensive genome analysis of L. brevis CRL 2013 was performed to identify the presence of antibiotic resistance genes, virulence markers, and genes associated with the glutamate decarboxylase system, which is essential for GABA biosynthesis. Then, an optimized chemically defined culture medium (CDM) was supplemented with monosodium glutamate (MSG) and yeast extract (YE) to analyze their influence on GABA production. Proteomic and transcriptional analyses were conducted to assess changes in protein and gene expression related to GABA production.ResultsThe absence of antibiotic resistance genes and virulence markers in the genome of L. brevis CRL 2013 supports its safety for potential probiotic applications. Genes encoding the glutamate decarboxylase system, including two gad genes (gadA and gadB) and the glutamate antiporter gene (gadC), were identified. The gadB gene is located adjacent to gadC, while gadA resides separately on the chromosome. The transcriptional regulator gadR was found upstream of gadC, with transcriptional analyses demonstrating cotranscription of gadR with gadC. Although MSG supplementation alone did not activate GABA synthesis, the addition of YE significantly enhanced GABA production in the optimized CDM containing glutamate. Proteomic analysis revealed minimal differences between MSG-supplemented and non-supplemented CDM cultures, whereas YE supplementation resulted in significant proteomic changes, including upregulation of GadB. Transcriptional analysis confirmed increased expression of gadB and gadR upon YE supplementation, supporting its role in activating GABA production.ConclusionThese findings provide valuable insights into the influence of nutrient composition on GABA production. Furthermore, they unveil the potential of L. brevis CRL 2013 as a safe, nonpathogenic strain with valuable biotechnological traits which can be further leveraged for its probiotic potential in the food industry.
The synergistic effects of mechanical ventilation and intrauterine inflammation on cerebral inflammation in preterm fetal sheep
Authors: Tran Nhi T. , Somers Ainsley , Vidinopoulos Kayla , Azman Zahrah , Pham Yen , Zahra Valerie A. , Chan Kyra Y. Y. , Hooper Stuart , Crossley Kelly , Allison Beth J. , Galinsky Robert , Polglase Graeme R. 
Published: June 2024

BackgroundIntrauterine inflammation and the requirement for mechanical ventilation independently increase the risk of perinatal brain injury and adverse neurodevelopmental outcomes. We aimed to investigate the effects of mechanical ventilation for 24 h, with and without prior exposure to intrauterine inflammation, on markers of brain inflammation and injury in the preterm sheep brain.MethodsChronically instrumented fetal sheep at ~115 days of gestation were randomly allocated to receive a single intratracheal dose of 1 mg lipopolysaccharide (LPS) or isovolumetric saline, then further randomly allocated 1 h after to receive mechanical ventilation with room air or no mechanical ventilation (unventilated control + saline [UVC, n = 7]; in utero mechanical ventilation + saline [VENT, n = 8], unventilated control + intratracheal LPS [UVC + LPS, n = 7]; in utero ventilation + intratracheal LPS [VENT + LPS, n = 7]). Serial fetal blood and plasma samples were collected throughout the experimental protocol for assessment of blood biochemistry and plasma interleukin (IL)-6 levels. After 24 h of mechanical ventilation, fetal brains were collected for RT-qPCR and immunohistochemical analyses.ResultsLPS exposure increased numbers of microglia and upregulated pro-inflammatory related genes within the cortical gray matter (GM) and subcortical white matter (SCWM) (pLPS &lt; 0.05). Mechanical ventilation alone increased astrocytic cell density in the periventricular white matter (PVWM) (pVENT = 0.03) but had no effect on pro-inflammatory gene expression. The combination of ventilation and LPS increased plasma IL-6 levels (p &lt; 0.02 vs. UVC and VENT groups), and exacerbated expression of pro-inflammatory-related genes (IL1β, TLR4, PTGS2, CXCL10) and microglial density (p &lt; 0.05 vs. VENT).ConclusionThis study demonstrates that 24 h of mechanical ventilation after exposure to intrauterine inflammation increased markers of systemic and brain inflammation and led to the upregulation of pro-inflammatory genes in the white matter. We conclude that 24 h of mechanical ventilation following intrauterine inflammation may precondition the preterm brain toward being more susceptible to inflammation-induced injury.