bluuebunny/crossref_metadata_2025_split huggingface dataset:
Influence of snow on near-surface ground temperatures in upland and alluvial environments of the outer Mackenzie Delta, Northwest Territories1This article is one of a series of papers published in this CJES Special Issue on the theme of Fundamental and applied research on permafrost in Canada.
Authors: Morse P.D. , Burn C.R. , Kokelj S.V. 
Published: July 2012

Relations between snow cover, active-layer thickness, and near-surface ground temperatures were determined in 2005–2009 for a diverse range of alluvial and upland settings in the outer Mackenzie Delta. Here, the snow cover developed primarily by wind redistribution, with its spatial variation controlled by topography in uplands and vegetation height in alluvial lowlands. Snow cover was the primary influence on freeze-back duration and the mean annual temperature at the top of permafrost (TTOP), with the difference in median TTOP between alluvial (–3.7 °C) and upland (–6.1 °C) settings related to the greater snow depth and soil moisture in the alluvial plain. The active layer was generally deeper in the wet alluvial lowlands, where the average duration of active-layer freeze back (101 days) was nearly double the time taken in the well-drained uplands (55 days). The surface offset (ΔTS; up to 11 °C) dominated the difference between annual mean air temperature (AMAT) and TTOP (ΔT). In alluvial terrain, ΔTS varied with snow depth, but in the uplands, ΔTS was more consistent from site to site. The small thermal offset (<2 °C) was slightly greater in alluvial terrain than in the uplands. The overall range in ΔT (2–10 °C) led to a range during the study of 7.2 °C in TTOP at the sites. The range in AMAT was 1.3 °C but up to 1.7 °C in TTOP at any one site. Permafrost was well established throughout the area except adjacent to channels where TTOP was close to 0 °C.
Geomorphology of a thermo-erosion gully, Bylot Island, Nunavut, Canada1This article is one of a series of papers published in this CJES Special Issue on the theme of Fundamental and applied research on permafrost in Canada.2Polar Continental Shelf Project Contribution 043-11.
Authors: Godin Etienne , Fortier Daniel 
Published: July 2012

A thermo-erosion gully has been monitored in the valley of glacier C-79 on Bylot Island since 1999. The main channel of the gully reached 390 m in length a few months after its initiation and grew between 38 and 50 m/year over the following decade, for an overall approximated average of 75 m/year. In 2009, the total gully length and area, including the main and relict channels, were 2500 m and 25 000 m2, respectively. Gullies affect snow accumulation, and therefore ground temperature, local water flow, and drainage. Sinkholes, gully heads, pools, baydzherakhi, tunnels, and collapses were grouped as a function of time since gully formation in that area. Sinkholes and tunnels were formed every year after gully inception, and baydzherakhi were found in 3–10 year old sections of the gully. Stabilization of the gully floor and sides took about a decade.
Cryostratigraphic record of permafrost degradation and recovery following historic (1898–1992) surface disturbances in the Klondike region, central Yukon Territory1This article is one of a series of papers published in this CJES Special Issue on the theme of Fundamental and applied research on permafrost in Canada.2Yukon Geological Survey Contribution 008.
Authors: Calmels Fabrice , Froese Duane G. , Clavano Wendy R. 
Published: July 2012

We present a detailed cryostratigraphic reconstruction of the degradation and recovery of near-surface permafrost in the southern Klondike goldfields, central Yukon Territory. Two ice-rich layers are recognized in near-surface permafrost and attributed to thermal impacts following vegetation disturbance. At an undisturbed forest site, the base of the modern active layer is stable. At an adjacent site, where a late twentieth century disturbance of surface vegetation and permafrost degradation occurred, there is evidence of recovery in the form of aggradation (upward shift) of the permafrost table following limited vegetation succession. Underlying both the undisturbed forest and the late twentieth century disturbance is an older thaw unconformity corresponding to a thaw depth of ∼2 m, likely associated with early twentieth century (gold rush era) impacts. Field and air photo surveys allow identification of the nature of the disturbances, while a chronology of the surface disturbance has been established using age estimates from tree rings, and the presence of tritium and post-bomb 14C from organic samples within aggradational ice. Collectively, these data underscore the importance of vegetation cover in maintaining ground temperatures in the discontinuous permafrost zone and suggest that, at least at the study site in recent decades, permafrost shows the potential to recover from disturbance in the modern climatic regime of the region.
RÉPARTITION GALOISIENNE D'UNE CLASSE D'ISOGÉNIE DE COURBES ELLIPTIQUES
Authors: RICHARD RODOLPHE 
Published: July 2012

Dans cet article, on montre que les orbites sous Galois des invariants modulaires associés à des courbes elliptiques complexes sans multiplication complexe variant dans une même classe d'isogénie s'équidistribuent dans la courbe modulaire vers la probabilité hyperbolique. La démonstration repose sur des arguments de théorie ergodique, notamment le théorème de Ratner (cf. [A. Eskin et H. Oh, Ergodic theoretic proof of equidistribution of Hecke points, Ergodic Theory Dynam. Systems26(1) (2006) 163–167]), ainsi que sur le théorème de l'image ouverte de Serre [J.-P. Serre, Abelian l-Adic Representations and Elliptic Curves (W. A. Benjamin, New York, 1968); Propriétés Galoisiennes des points d'ordre fini des courbes elliptiques, Invent. Math.15(4) (1972) 259–331] dans le cas où les invariants modulaires considérés sont algébriques sur Q, et des résultats de G. Shimura dans le cas transcendant [Introduction to the Arithmetic Theory of Automorphic Functions, Publications of the Mathematical Society of Japan (Princeton University Press, Princeton, NJ, 1994)]. In this article, it is shown that Galois orbits of invariants associated with non-CM and pairwise isogeneous complex elliptic curves equidistribute in the classical modular curve towards the hyperbolic probability measure. The proof is based on arguments from ergodic theory, especially Ratner's theorem on unipotent flows (cf. [A. Eskin and H. Oh, Ergodic theoretic proof of equidistribution of Hecke points, Ergodic Theory Dynam. Systems26(1) (2006) 163–167]), as well as on Serre's open image theorem [J.-P. Serre, Abelian l-Adic Representations and Elliptic Curves (W. A. Benjamin, New York, 1968); Propriétés Galoisiennes des points d'ordre fini des courbes elliptiques, Invent. Math.15(4) (1972) 259–331] in case of algebraic invariants, and on G. Shimura's work in the transcendant case [Introduction to the Arithmetic Theory of Automorphic Functions, Publications of the Mathematical Society of Japan (Princeton University Press, Princeton, NJ, 1994)].
Global Quantitative Phosphoproteome Analysis of Human Tumor Xenografts Treated with a CD44 Antagonist
Authors: Weigand Stefan , Herting Frank , Maisel Daniela , Nopora Adam , Voss Edgar , Schaab Christoph , Klammer Martin , Tebbe Andreas 
Published: July 2012

Abstract
The cell surface glycoprotein CD44 plays an important role in the development and progression of various tumor types. RG7356 is a humanized antibody targeting the constant region of CD44 that shows antitumor efficacy in mice implanted with CD44-expressing tumors such as MDA-MB-231 breast cancer cells. CD44 receptor seems to function as the main receptor for hyaluronic acid and osteopontin, serving as coreceptor for growth factor pathways like cMet, EGFR, HER-2, and VEGFR and by cytoskeletal modulation via ERM and Rho kinase signaling. To assess the direct impact of RG7356 binding to the CD44 receptor, a global mass spectrometry–based phosphoproteomics approach was applied to freshly isolated MDA-MB-231 tumor xenografts. Results from a global phosphoproteomics screen were further corroborated by Western blot and ELISA analyses of tumor lysates from CD44-expressing tumors. Short-term treatment of tumor-bearing mice with RG7356 resulted in modifications of the MAPK pathway in the responsive model, although no effects on downstream phosphorylation were observed in a nonresponsive xenograft model. Taken together, our approach augments the value of other high throughput techniques to identify biomarkers for clinical development of targeted agents. Cancer Res; 72(17); 4329–39. ©2012 AACR.
Enhancement of Synthetic Lethality via Combinations of ABT-888, a PARP Inhibitor, and Carboplatin In Vitro and In Vivo Using BRCA1 and BRCA2 Isogenic Models
Authors: Clark Caroline C. , Weitzel Jeffrey N. , O'Connor Timothy R. 
Published: July 2012

Abstract
Individuals with an inherited BRCA1 or BRCA2 mutation have an elevated risk of developing breast cancer. The resulting tumors typically lack homologous recombination repair as do a subset of sporadic tumors with acquired BRCA deficiency. Clinical responses to monotherapy with platinum drugs or poly PARP inhibitors (PARPi) have been shown for BRCA-associated cancers. However, there are limited data on combination therapy with PARPi and platinum drugs, the mechanism of action of this combination, and the role of BRCA1 or BRCA2 in chemosensitivity. We compared the efficacy of ABT-888 (a PARPi) with that of cisplatin or carboplatin (platinum drugs) alone or in combinations by examining the survival of treated Brca-proficient and -deficient mouse embryonic stem cells. In addition, drug-induced growth inhibition of a BRCA1 and a BRCA2 null cell line were compared with their isogenic BRCA-complemented lines. Although each monotherapy killed or inhibited proliferation of Brca/BRCA-deficient cells, an enhanced effect was observed after treatment with ABT-888 in combination with carboplatin. Moreover, the ABT-888/carboplatin combination delayed tumor growth in Brca2 xenografts. The drugs caused DNA damage and apoptosis. Along with greater PARP activity in Brca/BRCA-deficient cells, these effects correlated with increased chemosensitivity. Our data suggest that ABT-888 and carboplatin combination treatment will be more successful than monotherapy in addressing many BRCA-associated cancers. A randomized phase II trial has recently been initiated to test this hypothesis to assist in the discovery of more effective therapies for patients with BRCA. Mol Cancer Ther; 11(9); 1948–58. ©2012 AACR.
Fibroblast Growth Factor Receptor 2 IIIc as a Therapeutic Target for Colorectal Cancer Cells
Authors: Matsuda Yoko , Hagio Masahito , Seya Tomoko , Ishiwata Toshiyuki 
Published: July 2012

Abstract
A high percentage of colorectal carcinomas overexpress a lot of growth factors and their receptors, including fibroblast growth factor (FGF) and FGF receptor (FGFR). We previously reported that FGFR2 overexpression was associated with distant metastasis and that FGFR2 inhibition suppressed cell growth, migration, and invasion. The FGFR2 splicing isoform FGFR2IIIb is associated with well-differentiated histologic type, tumor angiogenesis, and adhesion to extracellular matrices. Another isoform, FGFR2IIIc, correlates with the aggressiveness of various types of cancer. In the present study, we examined the expression and roles of FGFR2IIIc in colorectal carcinoma to determine the effectiveness of FGFR2IIIc-targeting therapy. In normal colorectal tissues, FGFR2IIIc expression was weakly detected in superficial colorectal epithelial cells and was not detected in proliferative zone cells. FGFR2IIIc-positive cells were detected by immunohistochemistry in the following lesions, listed in the order of increasing percentage: hyperplastic polyps &lt; low-grade adenomas &lt; high-grade adenomas &lt; carcinomas. FGFR2IIIc immunoreactivity was expressed in 27% of colorectal carcinoma cases, and this expression correlated with distant metastasis and poor prognosis. FGFR2IIIc-transfected colorectal carcinoma cells showed increased cell growth, soft agar colony formation, migration, and invasion, as well as decreased adhesion to extracellular matrices. Furthermore, FGFR2IIIc-transfected colorectal carcinoma cells formed larger tumors in subcutaneous tissues and the cecum of nude mice. Fully human anti-FGFR2IIIc monoclonal antibody inhibited the growth and migration of colorectal carcinoma cells through alterations in cell migration, cell death, and development-related genes. In conclusion, FGFR2IIIc plays an important role in colorectal carcinogenesis and tumor progression. Monoclonal antibody against FGFR2IIIc has promising potential in colorectal carcinoma therapy. Mol Cancer Ther; 11(9); 2010–20. ©2012 AACR.
VEGF/Neuropilin-2 Regulation of Bmi-1 and Consequent Repression of IGF-IR Define a Novel Mechanism of Aggressive Prostate Cancer
Authors: Goel Hira Lal , Chang Cheng , Pursell Bryan , Leav Irwin , Lyle Stephen , Xi Hualin Simon , Hsieh Chung-Cheng , Adisetiyo Helty , Roy-Burman Pradip , Coleman Ilsa M. , Nelson Peter S. , Vessella Robert L. , Davis Roger J. , Plymate Stephen R. , Mercurio Arthur M. 
Published: July 2012

Abstract
We show that the VEGF receptor neuropilin-2 (NRP2) is associated with high-grade, PTEN-null prostate cancer and that its expression in tumor cells is induced by PTEN loss as a consequence of c-Jun activation. VEGF/NRP2 signaling represses insulin-like growth factor-1 receptor (IGF-IR) expression and signaling, and the mechanism involves Bmi-1–mediated transcriptional repression of the IGF-IR. This mechanism has significant functional and therapeutic implications that were evaluated. IGF-IR expression positively correlates with PTEN and inversely correlates with NRP2 in prostate tumors. NRP2 is a robust biomarker for predicting response to IGF-IR therapy because prostate carcinomas that express NRP2 exhibit low levels of IGF-IR. Conversely, targeting NRP2 is only modestly effective because NRP2 inhibition induces compensatory IGF-IR signaling. Inhibition of both NRP2 and IGF-IR, however, completely blocks tumor growth in vivo.
Significance: These results identify a causal role for NRP2 and VEGF/NRP2 signaling in the behavior of aggressive prostate cancers by a mechanism that involves regulation of Bmi-1, a transcriptional repressor implicated in the etiology of prostate cancer induced by loss of PTEN function, and the repression of the IGF-IR. The therapeutic implications are significant because combined inhibition of NRP2 and IGF-IR overcomes the resistance induced by targeting each receptor individually. Cancer Discov; 2(10); 906–21. ©2012 AACR.
This article is highlighted in the In This Issue feature, p. 857.
Environmental Controls on the Surface Energy Budget over a Large Southern Inland Water in the United States: An Analysis of One-Year Eddy Covariance Flux Data
Authors: Liu Heping , Zhang Qianyu , Dowler Gordon 
Published: July 2012

Abstract
The authors analyzed the surface energy fluxes that were measured by an eddy covariance system over the Ross Barnett Reservoir in Mississippi for a 1-yr period in 2008. On a monthly basis over the course of the year, positive vertical temperature and vapor pressure differences were observed, though negative vertical temperature differences occurred occasionally during some short periods when overwater air masses were warmer than the water surface. Consequently, the unstable atmospheric surface layer (ASL) and sufficient mechanical mixing led to positive sensible H and latent λE heat fluxes. The quantities H and λE were distinctively out of phase with the net radiation Rn. The H and λE from the water to the ASL was still substantial on nights with a negative Rn and in winter when Rn was very small. From February to August, approximately 60%–91% of the Rn was used for H and λE, with the remainder being stored in the water. Fueled by the previously stored heat in the water, H and λE exceeded Rn by almost 3 times from September to January. Nighttime evaporation represented a large loss of water (i.e., λE = 82.8 W m−2 at night versus 91.4 W m−2 during the daytime). Intraseasonal and seasonal variations in H and λE were strongly affected by frequent passages of large-scale air masses that were brought in by different synoptic weather systems (e.g., cyclones or anticyclones). The authors’ analysis suggested that this southern reservoir responded to atmospheric forcings on both diurnal and seasonal scales in the same ways as northern lakes of comparable sizes and depths.
Spatial-Scale Characteristics of Precipitation Simulated by Regional Climate Models and the Implications for Hydrological Modeling
Authors: Rasmussen S. H. , Christensen J. H. , Drews M. , Gochis D. J. , Refsgaard J. C. 
Published: July 2012

Abstract
Precipitation simulated by regional climate models (RCMs) is generally biased with respect to observations, especially at the local scale of a few tens of kilometers. This study investigates how well two different RCMs are able to reproduce the spatial correlation patterns of observed summer precipitation for the central United States. On local scales, gridded precipitation observations and simulated precipitation are compared for the period of the 1987 First International Satellite Land Surface Climatological Project Field Experiment (FIFE) campaign. The results show that spatial correlation length scales on the order of 130 km are found in both observed data and RCM simulations. When simulations and observations are aggregated to different grid sizes, the pattern correlation significantly decreases when the aggregation length is less than roughly 100 km. Furthermore, the intermodel standard deviation between simulations with different domains or resolutions increases for aggregation lengths below ~130 km. Below this length scale there is a high level of randomness in the precise location of precipitation events. Conversely, spatial correlation values increase above this length scale, reflecting larger predictive certainty of the RCMs at larger scales. The findings on aggregated grid scales are shown to be largely independent of the underlying RCMs grid resolutions but not of the overall size of RCM domain. With regard to hydrological modeling applications, these findings indicate that precipitation extracted from the present RCM simulations at a catchment scale below the intermodel standard deviation length cannot be expected to accurately match observations.
Wavenumber–Frequency Spectra of Inertia–Gravity and Mixed Rossby–Gravity Waves in the Equatorial Pacific Ocean
Authors: Farrar J. Thomas , Durland Theodore S. 
Published: July 2012

Abstract
In the 1970s and 1980s, there was considerable interest in near-equatorial variability at periods of days to weeks associated with oceanic equatorial inertia–gravity waves and mixed Rossby–gravity waves. At that time, the measurements available for studying these waves were much more limited than today: most of the available observations were from scattered island tide gauges and a handful of short mooring records. More than a decade of the extensive modern data record from the Tropical Atmosphere Ocean (TAO)/Triangle Trans-Ocean Buoy Network (TRITON) mooring array in the Pacific Ocean is used to reexamine the internal-wave climate in the equatorial Pacific, with a focus on interpretation of the zonal-wavenumber/frequency spectrum of surface dynamic height relative to 500 decibars at periods of 3–15 days and zonal wavelengths exceeding 30° of longitude. To facilitate interpretation of the dynamic height spectrum and identification of equatorial wave modes, the spectrum is decomposed into separate spectra associated with dynamic height fluctuations that are symmetric or antisymmetric about the equator. Many equatorial-wave meridional modes can be identified, for both the first and second baroclinic mode. Zonal-wavenumber/frequency spectra of the zonal and meridional wind stress components are also examined. The observed wind stress spectra are used with linear theory of forced equatorial waves to provide a tentative explanation for the zonal-wavenumber extent of the spectral peaks seen in dynamic height. Examination of the cross-equatorial symmetry properties of the wind stress suggests that virtually all of the large-scale equatorial inertia–gravity and mixed Rossby–gravity waves examined may be sensitive to both zonal and meridional wind stress.
Evaluating Added Benefits of Assimilating GOES Imager Radiance Data in GSI for Coastal QPFs
Authors: Qin Zhengkun , Zou Xiaolei , Weng Fuzhong 
Published: July 2012

Abstract
The Geostationary Operational Environmental Satellites (GOES) provide high-resolution, temporally continuous imager radiance data over the West Coast (GOES-West currently known as GOES-11) and East Coast (GOES-East currently GOES-12) of the United States. Through a real case study, benefits of adding GOES-11/12 imager radiances to the satellite data streams in NWP systems for improved coastal precipitation forecasts are examined. The Community Radiative Transfer Model (CRTM) is employed for GOES imager radiance simulations in the National Centers for Environmental Prediction (NCEP) gridpoint statistical interpolation (GSI) analysis system. The GOES imager radiances are added to conventional data for coastal quantitative precipitation forecast (QPF) experiments near the northern Gulf of Mexico and the derived precipitation threat score was compared with those from six other satellite instruments. It is found that the GOES imager radiance produced better precipitation forecasts than those from any other satellite instrument. However, when GOES imager radiance and six different types of satellite instruments are all assimilated, the score becomes much lower than the individual combination of GOES and any other instrument. Our analysis shows that an elimination of Advance Microwave Sounding Unit-B (AMSU-B)/Microwave Humidity Sounder (MHS) data over areas where GOES detects clouds significantly improved the forecast scores from AMSU-B/MHS data assimilation.
A Thermodynamic Analysis of an Intense North American Arctic Air Mass
Authors: Turner Jessica K. , Gyakum John , Milrad Shawn M. 
Published: July 2012

Abstract
Northwestern Canada is a genesis region of arctic air masses often considered to be formed primarily through radiative processes. However, the details of their life cycle are poorly understood. This paper examines the formation, maintenance, and dissipation of an intense and long-lived arctic air mass, using a thermodynamic budget analysis.
The airmass formation is characterized by a deep-layer, multistage process that begins with snow falling into a nascent air mass. Radiative cooling from cloud tops begins the process. After the snow abates and clear skies are observed, the surface temperature drops rapidly, aided by the high emissivity of fresh snow cover, falling 17°C in two days, creating an intense but shallow temperature inversion. Once the surface temperature falls below the frost point, ice crystals form. Afterward, although the surface temperature remains constant, the height of the inversion rises, as radiative cooling at the top of the ice fog layer decreases temperatures.
During the maintenance phase, a cold-air damming structure is present with an anticyclone in the lee of the Canadian Rockies, low pressure in the Gulf of Alaska, and an intense baroclinic zone parallel to the mountains, separating warmer maritime air from colder continental air. The air mass persists for 12 days, undergoing several cycles of deep-layer weakening and intensification.