bluuebunny/crossref_metadata_2025_split huggingface dataset:
Multicentric Epithelioid Angiosarcoma of Bone
Authors: Yang Zhengming , Tao Huimin , Ye Zhaoming , Yang Disheng 
Published: August 2012

Bone epithelioid angiosarcoma is rare and generally shows positive immunostaining for epithelial markers. Multicentric bone epithelioid angiosarcoma is easily misdiagnosed as carcinoma, including metastatic carcinoma, multiple myeloma, and multiple lymphoma of bone.
This article describes a case of multicentric bone epithelioid angiosarcoma. The patient was first misdiagnosed as having metastatic carcinoma. Examination showed osteolytic lesions in the bilateral heels and the lower left humerus. The diagnosis was confirmed postoperatively and corrected after immunohistochemical analysis of the biopsy. The immunohistochemical analysis revealed that the tumor mass was strongly positive for CD31, factor VIII, vimentin, and neuron-specific enolase. The patient refused chemotherapy and died of lung metastasis 4 months postoperatively.
Most bone epithelioid angiosarcomas are immunopositive for epithelial markers (ie, keratin, cytokeratin, high-molecular-weight keratin, and epithelial membrane antigen), vascular endothelial markers (ie, CD31, CD34, and von Willebrand factor), and factor VIII–associated antigen. Bone epithelioid angiosarcoma shows a relatively high degree of malignancy. Patients often die of distant metastasis, including those found in the lung and lymph node tissue. A wide excision of epithelioid angiosarcoma should be performed during the operation of the primary tumor. A better understanding of the clinicopathologic features of this disease may help to clarify the confusion, provide better treatment, and improve the clinical prognosis.
LASIK Interface Complications: Etiology, Management, and Outcomes
Authors: Randleman J. Bradley , Shah Rupa D. 
Published: August 2012

PURPOSE:
To describe the etiology, diagnosis, clinical course, and management of LASIK interface complications.

METHODS:
Literature review.

RESULTS:

Primary interface complications include infectious keratitis, diffuse lamellar keratitis, central toxic keratopathy, pressure-induced stromal keratopathy (PISK), and epithelial ingrowth. Infectious keratitis is most commonly caused by Methicillin-resistant
Staphylococcus aureus
(early onset) or atypical
Mycobacterium
(late onset) postoperatively, and immediate treatment includes flap lift and irrigation, cultures, and initiation of broad-spectrum topical antibiotics, with possible flap amputation for recalcitrant cases. Diffuse lamellar keratitis is a white blood cell infiltrate that appears within the first 5 days postoperatively and is acutely responsive to aggressive topical and oral steroid use in the early stages, but may require flap lift and irrigation to prevent flap necrosis if inflammation worsens. In contrast, PISK is caused by acute steroid response and resolves only with cessation of steroid use and intraocular pressure lowering. Without appropriate therapy PISK can result in severe optic nerve damage. Central toxic keratopathy mimics stage 4 diffuse lamellar keratitis, but occurs early in the postoperative period and is noninflammatory. Observation is the only effective treatment, and flap lift is usually not warranted. Epithelial ingrowth is easily distinguishable from other interface complications and may be self-limited or require flap lift to treat irregular astigmatism and prevent flap melt.

CONCLUSIONS:
Differentiating between interface entities is critical to rapid appropriate diagnosis, treatment, and ultimate visual outcome. Although initial presentations may overlap significantly, the conditions can be readily distinguished with close follow-up, and most complications can resolve without significant visual sequelae when treated appropriately.
Hypopyon Uveitis Following LASIK in a Patient With Ulcerative Colitis
Authors: Liu Margaret P. , Hwang Frank S. , Dunn J.P. , Stark Walter J. , Bower Kraig S. 
Published: August 2012

PURPOSE:
To present a case of unilateral hypopyon uveitis that began 15 days after uneventful bilateral LASIK in a 24-year-old man with an undisclosed history of ulcerative colitis.

METHODS:
Case report.

RESULTS:
The hypopyon uveitis completely resolved after treatment with aggressive topical and oral steroid agents in combination with topical antibiotic coverage.

CONCLUSIONS:
Although rare, visually significant hypopyon uveitis may arise after LASIK in the setting of ulcerative colitis and positive human leukocyte antigen (HLA) B27. Early recognition and treatment can result in an excellent outcome. The exact relationship between hypopyon uveitis and LASIK is impossible to ascertain.
LASIK for Presbyopia Correction in Emmetropic Patients Using Aspheric Ablation Profiles and a Micro-monovision Protocol With the Carl Zeiss Meditec MEL 80 and VisuMax
Authors: Reinstein Dan Z. , Carp Glenn I. , Archer Timothy J. , Gobbe Marine 
Published: August 2012

PURPOSE:
To evaluate the monocular and binocular visual outcomes of LASIK with an aspheric micro-mono-vision protocol in emmetropic patients with presbyopia.

METHODS:
A retrospective, noncomparative case series included 296 eyes from 148 consecutive emmetropic patients with presbyopia who were treated with LASIK-induced micro-monovision. The CRS-Master software was used to generate ablation profiles for the MEL 80 excimer laser (Carl Zeiss Meditec) and flaps were created using the VisuMax femtosecond laser (Carl Zeiss Meditec). The target refraction was plano for distance eyes (dominant eye) and between −1.00 and −1.88 diopters (D) for near eyes. Patients were followed for 1 year. Emmetropia was defined for inclusion as spherical equivalent refraction ⩾− 0.88 D, sphere ⩽+1.00 D, and cylinder ⩽1.25 D. Median patient age was 55 years (range: 44 to 65 years). Median follow-up was 12.9 months.

RESULTS:

Mean deviation from intended correction was +0.02±0.35 D, with 91% within ±0.50 D and 100% within ±1.00 D. Of distance eyes, 95% achieved uncorrected distance visual acuity (UDVA) of 20/20 or better and 100% achieved 20/32 or better. Binocularly, 98% of patients achieved UDVA of 20/20 or better and 100% achieved 20/32 or better; 96% achieved uncorrected near visual acuity of J2 and 99% could read J3 or better. No eyes lost 2 or more lines of corrected distance visual acuity. An average increase of 0.05 logMAR was noted in distance-corrected near visual acuity. A small increase occurred in mesopic contrast sensitivity (CSV-1000, VectorVision Inc) at 3 cycles per degree (cpd) (
P
=.016) and no change at 6, 12, or 18 cpd.

CONCLUSIONS:
This aspheric micro-monovision protocol was a well-tolerated and effective procedure for treating emmetropic patients with presbyopia.
A multi‐disciplinary approach to marine shallow geohazard assessment
Authors: Marsset B. , Thomas Y. , Sultan N. , Gaillot A. , Stephan Y. 
Published: August 2012

ABSTRACTSeismic velocities together with sediment/rock compaction models are of common use in the oil industry to predict reservoir pressures and to detect and identify any potential hazard associated with over‐pressured formations. Excess pore pressure is a key parameter for geohazard assessment, nevertheless this approach is very seldom applied to shallow offshore engineering as it requires expensive ground‐truth boreholes.The simultaneous availability in the Bourcart‐Hérault canyon interfluve (Gulf of Lion – NW Mediterranean) of 1) geotechnical and sedimentological data (300 m boreholes) from the PROMESS project; 2) in situ pore pressure measurements; and 3) High Resolution (HR) seismic geophysical data showing the presence of active structures in relation to fluid circulation, allows the importance of a multi‐disciplinary approach to shallow geohazard assessment to be illustrated through a case study.The velocity field obtained from HR seismic data is interpreted in light of the neighbouring boreholes and resulting velocity anomalies are translated in terms of fluid overpressure and free gas content. Additional in situ surface geotechnical measurements (piezometers) are then taken into account and the role of these parameters is discussed.
William James and the Impetus of Stoic Rhetoric
Authors: Stroud Scott R. 
Published: August 2012

Abstract
The relationship between William James and the stoics remains an enigma. He was clearly influenced by reading Marcus Aurelius and Epictetus throughout his career. Some work has been done on the thematic convergences between Jamesian pragmatism and stoic thought, but this study takes a different path. I argue that the rhetorical style that James uses in arguing for his moral claims in front of popular audiences can be better understood if we see it in light of the stoic style of argumentation. I look at a text James read closely and recommended to close acquaintances—Marcus Aurelius's Meditations—to extract a sense of stoic rhetorical style. James's use of the stoic's tactics of vivid examples and rhetorical questions to shape the rhetorical experience of his audience and to thereby make his points becomes understandable as a possible extension of the stoic style of persuasion.
Avoiding Deliberative Democracy? Micropolitics, Manipulation, and the Public Sphere
Authors: Livingston Alexander 
Published: August 2012

AbstractThis article examines the critique of deliberative democracy leveled by William Connolly. Drawing on both recent findings in cognitive science as well on Gilles Deleuze's cosmological pluralism, Connolly argues that deliberative democracy, and the contemporary left more generally, is guilty of intellectualism for overlooking the embodied, visceral register of political judgment. Going back to Deleuze and Guattari's A Thousand Plateaus, this article reconstructs the working assumptions of Connolly's critique and argues that it unwittingly leads to an indefensible embrace of manipulation. Against his micropolitics of visceral manipulation, I propose an alternative route for realizing Connolly's politics of agonistic negotiation in the form of a critical theory of the public sphere.
Searching for Boredom in Ancient Greek Rhetoric:
Authors: Bruss Kristine 
Published: August 2012

AbstractThe term “boring” is pervasive in contemporary popular evaluations of speakers and speeches. Although familiar today, the term is curiously absent from foundational Greek accounts of the art of rhetoric, raising a question about what, if anything, ancient Greeks thought about the subject. In this article, I aim to clarify Greek ways of thinking about boredom and rhetoric through an examination of the texts of Isocrates, focusing in particular on his Panathenaicus. As the evidence in Isocrates suggests, ancient Greek listeners did experience something akin to boredom, namely ochlos, or annoyance. The Greeks were also delighted (and hence not bored) by certain forms of rhetoric; some forms were delightful to crowds, and others, like the texts of Isocrates, were delightful to cultivated minds. Although Isocrates addresses antecedents of boredom, he makes only a handful of references of this sort, suggesting that boredom has afflicted some rhetorical cultures far less than others.
Applying Retrieval‐Induced Forgetting to Children's Testimony
Authors: Phenix Thomas L. , Price Heather L. 
Published: August 2012

SummaryWhen a crime has been committed, investigators must obtain as much and as accurate information as possible from witnesses. Initial incomplete interviews may pose a potential cost to unretrieved information. We explored retrieval‐induced forgetting (RIF) in children's autobiographical memory for related episodic events. Children experienced four related play sessions across 4 days, followed by word stem retrieval practice of half of the items, and a cued recall task that took place either 15 minutes or 2 hours later. Categorized details were experienced either within a single day or across multiple days. The emergence of RIF was dependent upon the length of delay between practice and test phases and the temporal distribution of the episodic events. Our observations demonstrate that RIF can be a subtle phenomenon whose occurrence depends upon whether the retrieval context supports an environment of retrieval interference. Copyright © 2012 John Wiley & Sons, Ltd.
1,10‐Phenanthroline‐Catalyzed Tandem Reaction of 2‐Iodoanilines with Isothiocyanates in Water
Authors: Zhang Wu , Yue Yun , Yu Dan , Song Lei , Xu Yang‐Yang , Tian Yu‐Jie , Guo Yu‐Jun 
Published: August 2012

AbstractThe 1,10‐phenanthroline‐catalyzed tandem reaction of 2‐iodoaniline with isothiocyanate in water is described, which provides an environmentally benign, efficient and simple route for the preparation of 2‐aminobenzothiazoles. The present tandem process shows broad substrate scope in the absence of transition metals and phase‐transfer catalysts.
Workplace violence and influencing factors among medical professionals in China
Authors: Wu Siying , Zhu Wei , Li Huangyuan , Lin Shaowei , Chai Wenli , Wang Xiaorong 
Published: August 2012

AbstractBackgroundWorkplace violence has attracted increasing public attention over the past few decades in China. This study was conducted to evaluate the frequency of workplace violence in healthcare settings by various job titles and hospital departments, and to explore the related risk factors among Chinese medical professionals.MethodsA total of 2,464 medical professionals in 12 hospitals of two provinces were surveyed by using a stratified cluster sampling method. The Chinese version of the Workplace Violence Scale was used to measure the frequencies of workplace violence, classified as physical assault, emotional abuse, threat of assault, verbal sexual harassment and sexual assault experienced by the subjects over the previous 12 months. A structured questionnaire was administered to collect information on potentially influencing factors for workplace violence. Multivariate analysis was applied to determine the risk factors for workplace violence.ResultsAbout 50% of study subjects reported at least one type of workplace violence. The rates of experiencing two episodes or more of physical assault, emotional abuse, threat of assault, verbal sexual harassment, and sexual assault were 11%, 26%, 12%, 3%, and 1%, respectively. Identified risk factors for workplace violence included working in the departments of psychiatry, emergency, pediatrics and surgery, male gender, divorce/widowed status, long working hours (≥10 hr/day), and night shift.ConclusionsThe study suggested that workplace violence occurs commonly in Chinese healthcare settings. Effective intervention strategies targeting workplace violence should be formulated in terms of major risk factors. Am. J. Ind. Med. 55:1000–1008, 2012. © 2012 Wiley Periodicals, Inc.
Job strain and heart rate variability in resident physicians within a general hospital
Authors: Hernández‐Gaytan Sendy Isarel , Rothenberg Stephen J. , Landsbergis Paul , Becerril Leonor Cedillo , De León‐León Guillermo , Collins Sean M. , Díaz‐Vásquez Francisco Javier 
Published: August 2012

AbstractObjectiveTo evaluate the association of heart rate variability with job strain in first year resident physicians.MethodsWe performed the study at the “Manuel Gea González” General Hospital in Mexico City. 54 resident doctors were studied over a period of 24 hr in their first year of specialization. Two questionnaires were administered: the first on general demographics, and the second, the Job Content Questionnaire. Heart rate variability was evaluated through the frequency domain (low‐frequency power, high‐frequency power, and low‐frequency power/high‐frequency power ratio) and time domain (SDNN). The doctors wore a Holter monitor over a 24‐hr period, which included a workday plus their on‐call time. They recorded their activities in a log.ResultsCompared to physicians in the “low strain” category, physicians working in the “passive” category had lower overall peak‐to‐peak cardiac variability (standard deviation of N–N intervals, SDNN), −9.08% (95% CI −17.97, 0.74), a −25% (95% CI −45.00, 0.22) lower high‐frequency power, and −26.95% (95% CI −39.00, −12.53) lower low‐frequency power. Physicians working in the “high strain” category had lower low‐frequency power, −17.85% (95%CI −32.34, −0.25), and lower low‐frequency/high‐frequency ratio −24.29% (95% CI 38.08, 7.42) compared to those in the “low strain” category.ConclusionsHigh job strain and low job control among medical residents were associated with several indicators of lowered heart rate variability. Thus, analysis of heart rate variability may be an informative marker for evaluating the physiological impacts of workplace stressors. Am. J. Ind. Med. 56:38–48, 2013. © 2012 Wiley Periodicals, Inc.
BPES with atypical premature ovarian insufficiency, and evidence of mitotic recombination, in a woman with trisomy X and a translocation t(3;11)(q22.3;q14.1)
Authors: Schlade‐Bartusiak Kamilla , Brown Lindsay , Lomax Brenda , Bruyère Hélène , Gillan Tanya , Hamilton Sara , McGillivray Barbara , Eydoux Patrice 
Published: August 2012

AbstractBlepharophimosis–ptosis–epicanthus inversus syndrome (BPES) is a rare autosomal dominant disorder characterized by a complex dysgenesis of the eyelids and premature ovarian insufficiency. FOXL2 located at 3q22.3, encoding a forkhead transcription factor, is the only gene known to be responsible for BPES. We describe a patient diagnosed with BPES with atypical ovarian failure, characterized by normal levels of gonadotropins, who was found to have trisomy X as well as a translocation (3;11)(q22.3;q14.1). The translocation breakpoint at 3q22.3 is located upstream of the FOXL2 gene and most likely causes BPES by separating the FOXL2 transcription unit from its cis‐regulatory sequences. By array analysis we detected mosaicism for the balanced and an unbalanced form of the translocation in blood cells. We propose mitotic recombination as the likely mechanism of the mosaicism formation. Mitotic recombination is a common phenomenon in human cells. Thus, we hypothesize that it may be one of the mechanisms responsible for cryptic imbalances and possible abnormal phenotypes in some carriers of balanced rearrangements. © 2012 Wiley Periodicals, Inc.
17q12 microdeletion syndrome: Three patients illustrating the phenotypic spectrum
Authors: Dixit Abhijit , Patel Chirag , Harrison Rachel , Jarvis Joanna , Hulton Sally , Smith Nigel , Yates Katherine , Silcock Lee , McMullan Dominic J. , Suri Mohnish 
Published: August 2012

AbstractDeletions of 17q12 are associated with renal cysts and maturity onset diabetes of the young, and have also been identified in women with reproductive tract anomalies due to Mullerian aplasia. Although initially identified in patients with normal cognitive ability, some patients with this recurrent microdeletion syndrome have learning problems. We identified a 17q12 microdeletion in three patients with renal cystic disease by array comparative genomic hybridization and the phenotypic spectrum of the 17q12 microdeletion syndrome is illustrated by the description of these patients. Of two patients who are old enough to be assessed, one has significant speech delay, autism spectrum disorder, and mild learning difficulty, while the other patient has only mild speech delay. This highlights the variability of cognitive involvement in this condition. The third patient presented with Alagille syndrome‐like features in the neonatal period. All three patients had transient hypercalcemia in the neonatal period, a finding that has not previously been described in this condition. Moreover, two patients have mild or no dysmorphism, while one displays striking facial dysmorphism in addition to minor congenital anomalies. We suggest that while patients with 17q12 microdeletion syndrome can present with type 2 diabetes or renal cysts without any dysmorphic features, a subgroup may have dysmorphic features or present with neonatal cholestasis. Transient neonatal hypercalcemia may be a feature of this microdeletion syndrome. © 2012 Wiley Periodicals, Inc.
Growth in Chilean infants with chromosome 22q11 microdeletion syndrome
Authors: Guzman Maria Luisa , Delgado Iris , Lay‐Son Guillermo , Willans Edward , Puga Alonso , Repetto Gabriela M. 
Published: August 2012

AbstractChromosome 22q11 microdeletion syndrome has a wide range of clinical manifestations including congenital heart malformations, palatal defects, endocrine abnormalities, immunologic deficits, learning difficulties, and an increased predisposition to psychiatric disease. Short stature and poor weight gain in infancy are common findings and are usually seen in the absence of hormone deficiencies. An increased frequency of obesity has been observed in adolescents and adults. We generated gender‐specific growth curves from 0 to 24 months of age, based on 479 length and 475 weight measurements from 138 Chilean patients with 22q11 deletion. Final adult height and weight on 25 individuals were analyzed. The 10th, 50th, and 90th centile‐smoothed curves for infants were built using the LMS method and compared with World Health Organization Child Growth Standards. The 50th centile for length in the deleted patients was slightly lower than the 10th centile of WHO standards in boys and girls. The same was observed for weight, although a trend toward a gradual increase near 2 years of age was observed, particularly in boys. Average adult height was 152 cm (ranging from 143 to 162 cm) in females, corresponding to the 10th centiles of WHO standards, and 166 cm for males (160–172 cm), at the 20th centile of WHO standards. A third of the adult females and none of the males had body mass index (BMI) greater than 25. The curves should be useful to monitor growth in infants with 22q11 microdeletion syndrome. © 2012 Wiley Periodicals, Inc.
Genotype–phenotype correlations in 17 Chinese patients with autosomal recessive Alport syndrome
Authors: Zhang Yanqin , Wang Fang , Ding Jie , Zhang Hongwen , Zhao Dan , Yu Lixia , Xiao Huijie , Yao Yong , Zhong Xuhui , Wang Suxia 
Published: August 2012

AbstractAutosomal recessive Alport syndrome (ARAS) results from mutations in the COL4A3 or COL4A4 gene. We analyzed the genotype and phenotype of 17 unrelated Chinese patients with ARAS. Clinical data were reviewed. All coding exons of COL4A3 and COL4A4 genes were PCR‐amplified and sequenced from genomic DNA. We identified pathologic mutations in all patients, giving a mutation detection rate of 100%, with 82% in COL4A3 gene and 18% in COL4A4 gene. Sixteen novel mutations in COL4A3 gene and four novel mutations in COL4A4 gene were identified. Furthermore, a previously reported in‐frame deletion mutation (40_63del24) in exon 1 of the COL4A3 gene was found in four patients in our study. A single 40_63del24 mutation in COL4A3 seems to result in mild or no renal manifestations, whereas the homozygous state of 40_63del24 in COL4A3 gene or compound heterozygous mutation of 40_63del24 plus another nonsense or frameshift mutation in COL4A3 gene seems to result severe ARAS with hearing loss. Half of the probands' parents had hematuria with or without mild proteinuria. Therefore, we recommend that ARAS be considered when a patient has a positive family history of hematuria, and screening for COL4A3 mutations firstly may be an efficient strategy for molecular diagnosis of ARAS. © 2012 Wiley Periodicals, Inc.