bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dichlorocarbenation of polar olefins in conditions of microwave irradiation
Authors: Borisova Yu. G. , Musin A. I. , Sultanova R. M. , Zlotskii S. S. 
Published: May 2024

Objectives. To evaluate the influence and efficiency of using microwave irradiation on the dichlorocarbenation of polar olefins. To determine the conditions (reaction time and process temperature) under which the maximum yield of target gem-dichlorocyclopropanes is achieved.Methods. The target compounds were obtained by classical methods of organic synthesis— acetalization of polyols and dichlorocarbenation of unsaturated compounds. The preparation of gem-dichlorocyclopropanes was carried out using the microwave activation method on a Sineo device (microwave system for organic synthesis, made in China). In order to determine the qualitative and quantitative composition of the reaction masses, gas–liquid chromatography (using the Kristall 2000 hardware complex), mass-spectroscopy (using Chromatek-Kristall 5000M device with NIST 2012), and nuclear magnetic resonance spectroscopy (using Bruker AM-500 device with operating frequencies of 500 and 125 MHz) were carried out.Results. Under microwave irradiation at 25°C for 2 h with the maximum yield (92–98%), the target substituted gem-dichlorocyclopropanes were obtained: 2-(2,2-dichloro-3-methylcyclopropyl)-1,3-dioxolane, 2-(2, 2-dichloro-3-phenylcyclopropyl)-1,3-dioxolane, 8,8-dichloro4-isopropyl-3,5-dioxabicyclooctane, diethyl-2,2-dichloro-3-phenylcyclopropane-1,1-dicarboxylate, and diethyl-2,2-dichloro-3isopropylcyclopropane-1,1-dicarboxylate.Conclusions. Under the conditions herein proposed, the use of the microwave stimulation method in the dichlorocarbenation of double C=C bonds containing polar substituents allows the reduce the temperature and reaction time to be significantly reduced, and the yield of target gem-dichlorocyclopropanes to be increased.
<i>One-pot</i> determination of amino acids in drugs by pre-column derivatization with phenyl isothiocyanate
Authors: Kalmykov P. A. , Kustova T P. , Kustov S. O. , Shestakovskaya P. S. , Azmetov T. R. , Kalmykova A. A. 
Published: May 2024

Objectives. To develop a new method to determine amino acids in drugs by means of reverse-phase high-performance chromatography (RP HPLC) with pre-column derivatization using phenyl isothiocyanate (PITC) and one-pot sample preparation.Methods. The initial standard solutions of amino acids were prepared by weighing, followed by dissolution in water. Working solutions were then prepared: standard, test, and blank, by dilution in 20 mM hydrochloric acid. Further sample preparation was carried out in Safe-lock polypropylene tubes (Eppendorf) in a reaction buff containing mobile phase A, acetonitrile, and triethylamine in a ratio of 85 : 10 : 5, labeled with a 5% PITC solution in acetonitrile. After thorough mixing for 3–5 min on a vortex, the tubes were kept in a solid-state thermostat with a thermally insulating lid for 2 h. The samples were then cooled for 10 min, centrifuged for 1 min at 13000 rpm, the supernatant was transferred into vials, and the mixture of amino acids was separated by RP HPLC using hydrophobic silica gel with grafted C18 groups as a stationary phase. The quantitative determination of amino acid derivatives was carried out using a diode array detector.Results. A new method for the separation and determination of amino acids in medicinal preparations was developed and validated. Simple one-pot sample preparation using available reagents and equipment enabled studies to be carried out without using commercial kits, for example, the AccQ.Tag Ultra Derivatization Kit, USA. Using the analysis of mixtures of histidine and glycine as an example, it was shown that when using two mobile phases, an acceptable separation of amino acid derivatives in a gradient mode can be achieved for 20 min at a flow rate of 1.0 mL/min. The samples prepared according to the new method demonstrated a high level of stability in use and storage. A composition of mobile phases A and B consisting of 10 mM acetate buffer pH 3.5 and 80% acetonitrile solution was proposed. Validation of the method hereby developed in the analysis of the drug Innonafactor®, containing glycine and histidine as excipients, demonstrated high convergence of the results of the quantitative determination of these amino acids.Conclusions. The new method to determine amino acids in medicinal preparations by RP HPLC with PITC pre-column derivatization has a wide range of applications, has a number of advantages when compared to imported commercial kits for the determination of amino acids. These include: lower cost of reagents and materials, high accuracy and repeatability. Thus, it can be recommended for use in quality control laboratories of pharmaceutical enterprises.
Natural and synthetic isoprene rubbers obtained using Ziegler–Natta catalysts
Authors: Zuev A. A. , Zolotarev V. L. , Levenberg I. P. , Kovaleva L. A. , Nasyrov I. Sh. 
Published: May 2024

Objectives. To compare the properties of rubber compounds and rubbers based on natural rubber RSS1 and synthetic isoprene rubbers obtained using Ti, Nd, Gd catalysts, both when used individually in the formulation of rubber compounds and when synthetic analogues partially replace natural rubber.Methods. Rubber compounds were prepared using a laboratory roll and a 100 cm3 rubber mixer. For rubber compounds, the following factors were determined: Mooney viscosity, cohesive strength, and vulcanization characteristics. For rubbers, the following factors were determined: physical and mechanical parameters, Shore A hardness, rebound resilience, and volume loss upon abrasion.Results. Based on the results of the rubber compound tests, the study showed that compounds based on all the synthetic polyisoprenes studied are significantly inferior to compounds based on natural rubber in terms of cohesive strength. The partial replacement of natural rubber with synthetic rubber (regardless of the type of catalytic system) leads to a significant decrease in the cohesive strength of the blends. Despite the differences observed in the properties of the rubber compounds, the results of the rubbers based on individual rubbers do not manifest significant differences.Conclusions. The study demonstrated the influence of defects (oligomers, gel, low molecular weight fractions, branches, and 3,4-units) in the structure of synthetic polyisoprenes on the cohesive strength index of rubber compounds based on them, in which the number of 3,4-units plays a decisive role. The study also showed the potential of studying synthetic polyisoprenes as analogues of natural rubber in formulations of rubber compounds in the aims of resolving the problem of import substitution in the tire and rubber goods industry.
Data-Driven Decision Making in Scholarship Programs: Leveraging Decision Trees and Clustering Algorithms
Authors: Espiritu Fokker V. , Natividad Marvee Cheska B. , Velasco Rosemary A. 
Published: May 2024

This study presents a unique and innovative approach to improving the management of scholarship programs through the integration of data mining techniques and online systems. The BRO-Ed Scholarship program in Isabela province is facing the challenge of efficiently handling a growing number of scholarship applications. This study involves leveraging data mining to simplify this process, address operational challenges, and contribute to the transformation of the lives of underprivileged students. Data mining techniques that include systematic data integration, preprocessing, decision tree implementation, and clustering algorithms were utilized in this study. Additionally, we have created a user-friendly online platform to enhance accessibility. Initial results show a significant increase in the success rate, indicating the potential of managing scholarships using data-driven approaches. The expected outcomes include a streamlined application process, informed decisions based on data-driven analysis, and optimized budget allocation. By establishing a model for innovative advancement in scholarship programs, this project aims to promote educational support initiatives for underprivileged students aligned with the government’s mandate for Sustainable Development Goal 4, addressing growing inequality among marginalized people and communities.
Keywords: Data Mining, Decision Trees, Clustering Algorithm, Scholarship Programs, Underprivileged Students, Sustainable Development Goal 4

Received Date: March 2, 2024Revised Date: April 22, 2024Accepted Date: May 4, 2024
PENGARUH KONFLIK, TEKANAN PEKERJAAN DAN STRES KERJA TERHADAP PRODUKTIVITAS KERJA PEGAWAI DI KANTOR BKPSDM (BADAN KEPEGAWAIAN & PENGEMBANGAN SUMBER DAYA MANUSIA) KOTA LUBUKLINGGAU
Authors: Dora Maresta , Wahyuni Wahyuni , Anjelina Mutiara 
Published: May 2024

Penelitian ini bertujuan untuk meneliti pengaruh konflik, tekanan pekerjaan dan stres kerja, terhadap produktivitas kerja pegawai di kantor BKPSDM Kota Lubuklinggau. Penelitian ini menggunakan jenis data sekunder bersifat kualitif. Populasi dalam penelitian ini adalah 50 orang. Analisis dalam penelitian ini menggunakan analisis Regresi Linier dengan menggunakan SPSS VERSI 20. Berdasarkan hasil uji menunjukkan bahwa hasil koefisien determinasi (R2) dari 3 variabel ke Y diperoleh 0,915 atau 91,5%. Uji F diperoleh F hitung sebesar 165.482 dengan nilai signifikansi 0,000 < 0,05 maka H0 ditolak. Ini berarti variabel Pengaruh knflik kerja, tekanan pekerjaan dan stres kerja berpengaruh secara simultan terhadap variabel produktivitas kerja pegawai di kantor BKPSDM Kota Lubuklinggau. Sedangkan untuk uji t konflik kerja memiliki pengaruh positif dan signifikan terhadap produktivitas kerja terlihat dari hasil uji t diperoleh nilai t hitung 6,108 dengan nilai sig 0,000 < 0,05 maka H0 ditolak. Sedangkan nilai t hitung tekanan pekerjaan sebesar 2,341 dengan nilai sig 0,024< 0,05 terhadap produktivitas kerja. Sedangkan nilai t hitung stres kerja sebesar 4.590 dengan nilai sig 0,000 < 0,05 artinya memiliki pengaruh positif terhadap produktivitas kerja
PENGARUH LINGKUNGAN KERJA DAN DISIPLIN KERJA TERHADAP KINERJA PEGAWAI DINAS BADAN PENELITIAN DAN PENGEMBANGAN KABUPATEN MUSI RAWAS
Authors: Azhar Rudi , Susilawati Susilawati 
Published: May 2024

Penelitian ini bertujuan untuk menguji secara empiris pengaruh lingkungan kerja dan disiplin kerja terhadap kinerja pegawai pada Dinas Badan Penelitian Dan Pengembangan Kabupaten Musi Rawas. Populasi dalam penelitian ini adalah pegawai Dinas Badan Penelitian Dan Pengembangan Kabupaten Musi Rawas. Sampel dalam penelitian ini adalah seluruh pegawai Dinas Badan Penelitian Dan Pengembangan Kabupaten Musi Rawas yaitu sebanyak 35 responden. Data yang digunakan adalah data primer yang diperoleh dari hasil penyebaran kuesioner kepada pegawai Dinas Badan Penelitian Dan Pengembangan Kabupaten Musi Rawas. Metode yang digunakan adalah analisis regresi linier sederhana dan berganda. Dari pengujian menunjukkan bahwa hipotesis pertama yaitu lingkungan kerja berpengaruh terhadap kinerja pegawai, hal ini dibuktikan dengan hasil analisis uji t yang menunjukan nilai t hitung = 9,711 lebih besar dari nilai ttabel (35-1=34) = 2,032 dengan nilai signifikan 0,000 < 0,05. Hipotesis kedua yaitu disiplin kerja berpengaruh terhadap kinerja pegawai, hal ini dibuktikan dengan hasil analisis uji t yang menunjukkan nilai t hitung = 10,793 lebih besar dari nilai ttabel (35-1=34) = 2,032 dengan nilai signifikan 0,000 < 0,05.. Dan hipotesis ketiga yaitu lingkungan kerja (X1) dan disiplin kerja (X2) secara simultan berpengaruh terhadap kinerja pegawai (Y), hal ini dibuktikan dari hasil analisis uji F menunjukkan nilai F hitung= 110,436 lebih besar dari nilai F tabel 3,295 dengan tingkat signifikan = 0,000 < 0,05.
ANALISIS KUALITAS LAYANAN PELANGGAN CAFE LAUNDRY MEDAN
Authors: Meisanni Meisanni , Nugroho Ngajudin 
Published: May 2024

Perkembangan dan permintaan dibidang usaha jasa menjadikan layanan sebagai suatu tolak ukur dalam mempertahankan konsumen dan sebagai pembeda dari layanan jasa pesaing. Kualitas layanan menentukan seberapa jauh perbedaan antara harapan dan kenyataan yang dirasakan dari pelayanan yang diterima baik sebagian maupun keseluruhan.Tujuan dalam penelitian ini adalah untuk mengetahui dan memahami kualitas layanan yang diharapkan oleh pelanggan Cafe Laundry sehingga dapat meningkatkan Kembali jumlah pelanggan. Metode penelitian yang dipakai adalah metode kualitatif dengan pengumpulan data melalui wawancara semiterstruktur. Sampel dalam penelitian ini adalah 8 orang pelanggan dari Cafe Laundry yang dipilih dengan kategori 4 orang pelanggan tetap yang sudah lebih dari 5 kali menggunakan jasa Cafe Laundry serta 4 orang pelanggan baru dengan minimal penggunaan jasa 1 kali. Pengambilan sampel menggunakan teknik purposive sampling. Hasil penelitian menunjukkan kualitas layanan Cafe Laundry cukup baik mulai dari fasilitas fisik yang disediakan, kemudahan transaksi pembayaran, karyawan yang cepat tanggap serta tersedianya layanan antar – jemput pakaian. Adapun yang perlu ditingkatan Cafe Laundry untuk menghasilkan layanan optimal dan mengatasi menurunnya jumlah pelanggan yaitu ketepatan waktu dalam antar-jemput pakaian, kebersihan area laundri, respons yang cepat dalam komunikasi online, memperbaiki respon karyawan yang kurang sopan dan ramah serta meningkatkan hasil cucian yang kurang maksimal.
Reinforcing the Frontlines: Experiences of Police Auxiliary during the Covid-19 Pandemic
Authors: Mendoza Jayrie , Dodelon Sabijon  , Yolanda Sayson  , Jasmin Bonggot  , John Kevin Bangaysiso  , And Joan Marie Oville  
Published: May 2024

This is a phenomenological study on the experiences of Task Force Kasaligan as auxiliary forces during the COVID-19 pandemic in Cebu City. Phenomenological interviewing was used in data gathering to describe the meaning of the phenomenon. This study was conducted in Cebu City, Philippines, where the participants were selected members of Task Force Kasaligan. These were ten participants who were chosen through purposive convenient sampling. The study utilized an interview Guide to elicit in-depth responses from the participants. The investigation aimed to explore several key areas: the personal experiences of individuals serving as police auxiliaries, the strategies they employ to address challenges faced while fulfilling their roles, and their goals for enhancing the service they provide to the community. Results revealed that three themes came up: two themes on positive and one on negative experiences of the participants in the performance of their duty as police auxiliary during the covid-19 pandemic which are: Knowledge and Competence Leads to Better Performance, Police Presence Makes COVID-19 Spread Lessened; and Bashing and Disrespecting Authorities Leads to COVID-19 Spread. Two themes in how the participants, as police auxiliaries, coped with the problems encountered in performing their duties: Expanding the Maximum Tolerance and Building Strong Collaboration. The aspirations of the participants to enhance the service quality provided to the community revealed two main themes: Firstly, the importance of "Holding on: Security of Tenure," highlighting the significance of job security. Secondly, "Moving on: The Need for Training and Development" emphasizes the necessity for continuous learning and skill enhancement. It was recommended that the Cebu City Police Office and the Task Force Kasaligan Personnel should conduct police partnership programs about the guidelines of COVID-19 health protocols in the different barangays in Cebu City. The purpose of this police partnership program is to strengthen the relationship of the Police Personnel and Task Force Kasaligan Personnel to the community's citizens and to ensure their cooperation.
Reconstruction of Vagina with Bilateral Pudendal Thigh Flap: A Solution for Atresia/ Agenesis of Vagina
Authors: Nazneen Most Afroza , Tisha Tania Afrin , Keya Summi Leonard 
Published: May 2024

Reconstruction of vagina is a technically challenging surgery. The aim is to create a functionally and aesthetically satisfactory neovagina in a way that will be reliable and suitable for most atients. Use of bilateral udendal thigh fla to create a neovagina may overthrow the conventional methods as there is no necessity for osto erative dilation or vaginal intercourse to maintain adequate vaginal length and diameter. Vaginal reconstruction was done with bilateral udendal thigh fla s, in seven atients with vaginal agenesis, during 2 years, from July 2021 to June 2023. This method of vagino lasty is sim le, safe, and reliable and has shown satisfactory functional and cosmetic results. The reconstructed vagina has a natural angle and is sensate in its lower art. No osto erative stenting or dilatation is required. The donor site can be closed rimarily and the scar is well hidden in the groin crease.
TAJ 2023; 36: No-2: 11-16
Correlation with serum Lactate dehydrogenase level and Hematological parameters before and after induction of remission in childhood Acute lymphoblastic leukemia- A prospective study
Authors: Alam A K M Shamsul , Hoshen Md Ibrahim , Ahmmad Be Nazir , Sarke Sanchita , Amin Md Ruhul , Rahman Fazlur , Uddin Md Belal 
Published: May 2024

The relationship between serum LDH (lactate dehydrogenase) and the course of neoplasia had been well established in different studies. It might be a promising tool as assessing serum is easy, readily available and cheap in the prognosis of childhood Acute Lymphoblastic Leukemia (ALL). This study is aimed to evaluate the role of serum LDH before and after induction of remission in childhood ALL. This study was conducted at the Department of Pediatrics, Rajshahi Medical College Hospital, and Rajshahi for a period of two years. Total 30 children aged from 1-12 years newly diagnosed cases of ALL were included. Each patient underwent clinical evaluation and relevant investigations. All information was recorded in a separate case record form. Collected data were analyzed using the statistical software SPSS 23. Mean age of the studied children was 5.03±3.17 years. Male children were 66.7% and female children were 33.3%. Mean value of serum LDH was significantly lower at 29th days of induction of remission compared to the value before chemotherapy (432.40±310.52 U/L vs. 829.10±345.58 U/L, p<0.05). Mean peripheral blast cell also reduced after chemotherapy (30.03±16.41% Vs. 0.37±0.96%). Pearson correlation model showed strong positive correlation between LDH level and bone marrow blast cell at both before and after chemotherapy (r> +0.75, p<0.001). This study observed significant reduction of LDH after chemotherapy and positive linear relation with peripheral blast cells.
TAJ 2023; 36: No-2: 83-92
Peran Perempuan dalam Meningkatkan Penghasilan Keluarga Melalui Pengelolaan Jagung Titi di Desa Kolipadan Kecamatan Ile Ape Kabupaten Lembata Provinsi Nusa Tenggara Timur
Authors: Pongge Maria Imakulata , Tje Yustin Dima Enike 
Published: May 2024

In Kolipadan Village, Ile Ape District, Lembata Regency, the emphasis on family economic capability has created chances for women to maximize the varied family welfare potentials. Several factors include husbands who have passed away, husbands who don't have a stable career, and husbands who earn a livelihood overseas (migration). To help raise family income, a variety of initiatives and opportunities are used, including the regional specialty, namely titi corn, also known locally as Wata Kena'e in Kolipa Village and Ileape District, Lembata District. This study seeks to understand the role of female heads of home in boosting family income to satisfy family requirements through selling titi corn. In this study, the sale of titi corn in particular, is examined, along with the selling price and technique of processing. Both primary and secondary data were used in this investigation. Interviews with 25 female head-of-household respondents in Kolipadan Village provided the primary data. Secondary data comes from data-related offices, namely population density and the number of female workers. A qualitative technique and descriptive analysis were both used in the data analysis for this investigation. The findings demonstrated that women significantly contribute to raising family income by processing corn titi. For one kilogram of corn, titi corn processing costs IDR 10,000 in raw materials and takes a half-day to complete. Titi corn is sold for between IDR 50,000 and IDR 100,000 per kilogram. Monthly revenue from corn sales ranges between IDR 500,000 and IDR 1,500,000. In order for the family to be able to meet its fundamental needs, social and psychological needs, and developmental needs and be considered affluent, women must be the head of the household and must work to improve the family's economics.
A graph model to describe the network connectivity of trabecular plates and rods
Authors: Walle Matthias , Yeritsyan Diana , Abbasian Mohammadreza , Oftadeh Ramin , Müller Ralph , Nazarian Ara 
Published: May 2024

Introduction: The trabecular network is perceived as a collection of interconnected plate- (P) and rod-like (R) elements. Previous research has highlighted how these elements and their connectivity influence the mechanical properties of bone, yet further work is required to elucidate better the deeply interconnected nature of the trabecular network with distinct element formations conducting forces per their mechanical boundary conditions. Within this network, forces act through elements: a rod or plate with force applied to one end will transmit this force to a component connected to the other end, defining the boundary conditions for the loading of each element. To that end, this study has two aims: First, to investigate the connectivity of individually segmented elements of trabecular bone with respect to their local boundary conditions as defined by the surrounding trabecular network and linking them directly to the bone’s overall mechanical response during loading using a mathematical graph model of the plate and rod (PR) Network. Second, we use this model to quantify side artifacts, a known artifact when testing an excised specimen of trabecular bone, where vertical trabeculae lose their load-bearing capacity due to a loss of connectivity, ultimately resulting in a change of the trabecular network topology.Resuts: Connected elements derived from our model predicted apparent elastic modulus by fitting a linear regression (R2= 0.81). In comparison, prediction using conventional bone volume fraction results in a lower accuracy (R2= 0.72), demonstrating the ability of the PR Network to estimate compressive elastic modulus independent of specimen size or loading boundary condition.Discussion: PR Network models are a novel approach to describing connectivity within the trabecular network and incorporating mechanical boundary conditions within the morphological analysis, thus enabling the study of intrinsic material properties of trabecular bone. Ultimately, PR Network models may be an early predictor or provide further insights into osteo-degenerative diseases.