bluuebunny/crossref_metadata_2025_split huggingface dataset:
Deep learning driven diagnosis of malignant soft tissue tumors based on dual-modal ultrasound images and clinical indexes
Authors: Xie Haiqin , Zhang Yudi , Dong Licong , Lv Heng , Li Xuechen , Zhao Chenyang , Tian Yun , Xie Lu , Wu Wangjie , Yang Qi , Liu Li , Sun Desheng , Qiu Li , Shen Linlin , Zhang Yusen 
Published: May 2024

BackgroundSoft tissue tumors (STTs) are benign or malignant superficial neoplasms arising from soft tissues throughout the body with versatile pathological types. Although Ultrasonography (US) is one of the most common imaging tools to diagnose malignant STTs, it still has several drawbacks in STT diagnosis that need improving.ObjectivesThe study aims to establish this deep learning (DL) driven Artificial intelligence (AI) system for predicting malignant STTs based on US images and clinical indexes of the patients.MethodsWe retrospectively enrolled 271 malignant and 462 benign masses to build the AI system using 5-fold validation. A prospective dataset of 44 malignant masses and 101 benign masses was used to validate the accuracy of system. A multi-data fusion convolutional neural network, named ultrasound clinical soft tissue tumor net (UC-STTNet), was developed to combine gray scale and color Doppler US images and clinic features for malignant STTs diagnosis. Six radiologists (R1-R6) with three experience levels were invited for reader study.ResultsThe AI system achieved an area under receiver operating curve (AUC) value of 0.89 in the retrospective dataset. The diagnostic performance of the AI system was higher than that of one of the senior radiologists (AUC of AI vs R2: 0.89 vs. 0.84, p=0.022) and all of the intermediate and junior radiologists (AUC of AI vs R3, R4, R5, R6: 0.89 vs 0.75, 0.81, 0.80, 0.63; p &lt;0.01). The AI system also achieved an AUC of 0.85 in the prospective dataset. With the assistance of the system, the diagnostic performances and inter-observer agreement of the radiologists was improved (AUC of R3, R5, R6: 0.75 to 0.83, 0.80 to 0.85, 0.63 to 0.69; p&lt;0.01).ConclusionThe AI system could be a useful tool in diagnosing malignant STTs, and could also help radiologists improve diagnostic performance.
The impact of the new ESTRO-ACROP target volume delineation guidelines for postmastectomy radiotherapy after implant-based breast reconstruction on breast complications
Authors: Park Jung Bin , Jang Bum-Sup , Chang Ji Hyun , Kim Jin Ho , Choi Chang Heon , Hong Ki Young , Jin Ung Sik , Chang Hak , Myung Yujin , Jeong Jae Hoon , Heo Chan Yeong , Kim In Ah , Shin Kyung Hwan 
Published: May 2024

The European Society for Radiotherapy and Oncology–Advisory Committee in Radiation Oncology Practice (ESTRO-ACROP) updated a new target volume delineation guideline for postmastectomy radiotherapy (PMRT) after implant-based reconstruction. This study aimed to evaluate the impact on breast complications with the new guideline compared to the conventional guidelines. In total, 308 patients who underwent PMRT after tissue expander or permanent implant insertion from 2016 to 2021 were included; 184 received PMRT by the new ESTRO-ACROP target delineation (ESTRO-T), and 124 by conventional target delineation (CONV-T). The endpoints were major breast complications (infection, necrosis, dehiscence, capsular contracture, animation deformity, and rupture) requiring re-operation or re-hospitalization and any grade ≥2 breast complications. With a median follow-up of 36.4 months, the cumulative incidence rates of major breast complications at 1, 2, and 3 years were 6.6%, 10.3%, and 12.6% in the ESTRO-T group, and 9.7%, 15.4%, and 16.3% in the CONV-T group; it did not show a significant difference between the groups (p = 0.56). In multivariable analyses, target delineation is not associated with the major complications (sHR = 0.87; p = 0.77). There was no significant difference in any breast complications (3-year incidence, 18.9% vs. 23.3%, respectively; p = 0.56). Symptomatic RT-induced pneumonitis was developed in six (3.2%) and three (2.4%) patients, respectively. One local recurrence occurred in the ESTRO-T group, which was within the ESTRO-target volume. The new ESTRO-ACROP target volume guideline did not demonstrate significant differences in major or any breast complications, although it showed a tendency of reduced complication risks. As the dosimetric benefits of normal organs and comparable oncologic outcomes have been reported, further analyses with long-term follow-up are necessary to evaluate whether it could be connected to better clinical outcomes.
Sodium-glucose cotransporter-2 inhibitors and incidence of atrial fibrillation in older adults with type 2 diabetes: a retrospective cohort analysis
Authors: Li Yujia , Tang Huilin , Guo Yi , Shao Hui , Kimmel Stephen E. , Bian Jiang , Schatz Desmond A. , Guo Jingchuan 
Published: May 2024

ObjectivesTo investigate the risk of atrial fibrillation (AF) with sodium-glucose cotransporter-2 inhibitors (SGLT2is) compared to dipeptidyl peptidase-4 inhibitor (DPP4i) use in older US adults and across diverse subgroups.MethodsWe conducted a retrospective cohort analysis using claims data from 15% random samples of Medicare fee-for-service beneficiaries. Patients were adults with type 2 diabetes (T2D), no preexisting AF, and were newly initiated on SGLT2i or DPP4i. The outcome was the first incident AF. Inverse probability treatment weighting (IPTW) was used to balance the baseline covariates between the treatment groups including sociodemographics, comorbidities, and co-medications. Cox regression models were used to assess the effect of SGLT2i compared to DPP4i on incident AF.ResultsOf the 97,436 eligible individuals (mean age 71.2 ± 9.8 years, 54.6% women), 1.01% (n = 983) had incident AF over a median follow-up of 361 days. The adjusted incidence rate was 8.39 (95% CI: 6.67–9.99) and 11.70 (95% CI: 10.9–12.55) per 1,000 person-years in the SGLT2i and DPP4i groups, respectively. SGLT2is were associated with a significantly lower risk of incident AF (HR 0.73; 95% CI, 0.57 to 0.91; p = 0.01) than DPP4is. The risk reduction of incident AF was significant in non-Hispanic White individuals and subgroups with existing atherosclerotic cardiovascular diseases and chronic kidney disease.ConclusionCompared to the use of DPP4i, that of SGLT2i was associated with a lower risk of AF in patients with T2D. Our findings contribute to the real-world evidence regarding the effectiveness of SGLT2i in preventing AF and support a tailored therapeutic approach to optimize treatment selection based on individual characteristics.
Moderating effect of negative emotion differentiation in chronic stress and fatigue among Chinese employees
Authors: Lv Wenhao , Qiu Huake , Lu Hongliang , Yajuan Zhang , Yongjie Ma , Xing Chen , Zhu Xia 
Published: May 2024

IntroductionAccording to the reactivity hypothesis and the diathesis-stress model, repeated activation of the stress system has a negative effect on health, and this effect may differ because of individual characteristics. Thus, the present study explores the effect of chronic stress on fatigue and investigates its mechanism.MethodsA questionnaire survey of 288 participants selected from the northwest part of China was conducted (13.89% females; ages ranged from 18 to 34 years, with M ± SD = 23.14 ± 3.79 years) on chronic stress, fatigue, depression, anxiety, and negative emotion differentiation. SPSS 28.0 was used to process descriptive statistics and correlation analysis and the PROCESS macro was used to analyze the moderated chained multi-mediation.ResultsChronic stress was found to be positively correlated with fatigue, depression, and anxiety; depression and anxiety played a chained multi-mediating role between chronic stress and fatigue, and negative emotion differentiation played a moderating role in the chained multi-mediation model.DiscussionCompared with depression, anxiety plays a more important role in the influence of chronic stress on fatigue. Therefore, it is necessary to pay more attention to anxiety symptoms and take appropriate intervention measures. Negative emotion differentiation plays a moderating role. Improving negative emotion differentiation through mindfulness and adaptive emotion regulation is an effective way to reduce the influence of chronic stress on fatigue.
Evaluating the Reliability of MyotonPro in Assessing Muscle Properties: A Systematic Review of Diagnostic Test Accuracy
Authors: Lettner Jonathan , Królikowska Aleksandra , Ramadanov Nikolai , Oleksy Łukasz , Hakam Hassan Tarek , Becker Roland , Prill Robert 
Published: May 2024

Background and Objectives: Muscle properties are critical for performance and injury risk, with changes occurring due to physical exertion, aging, and neurological conditions. The MyotonPro device offers a non-invasive method to comprehensively assess muscle biomechanical properties. This systematic review evaluates the reliability of MyotonPro across various muscles for diagnostic purposes. Materials and Methods: Following PRISMA guidelines, a comprehensive literature search was conducted in Medline (PubMed), Ovid (Med), Epistemonikos, Embase, Cochrane Library, Clinical trials.gov, and the WHO International Clinical Trials platform. Studies assessing the reliability of MyotonPro across different muscles were included. A methodological quality assessment was performed using established tools, and reviewers independently conducted data extraction. Statistical analysis involved summarizing intra-rater and inter-rater reliability measures across muscles. Results: A total of 48 studies assessing 31 muscles were included in the systematic review. The intra-rater and inter-rater reliability were consistently high for parameters such as frequency and stiffness in muscles of the lower and upper extremities, as well as other muscle groups. Despite methodological heterogeneity and limited data on specific parameters, MyotonPro demonstrated promising reliability for diagnostic purposes across diverse patient populations. Conclusions: The findings suggest the potential of MyotonPro in clinical assessments for accurate diagnosis, treatment planning, and monitoring of muscle properties. Further research is needed to address limitations and enhance the applicability of MyotonPro in clinical practice. Reliable muscle assessments are crucial for optimizing treatment outcomes and improving patient care in various healthcare settings.
In Vitro and In Silico Anti-Glioblastoma Activity of Hydroalcoholic Extracts of Artemisia annua L. and Artemisia vulgaris L.
Authors: Bernatoniene Jurga , Nemickaite Emilija , Majiene Daiva , Marksa Mindaugas , Kopustinskiene Dalia M. 
Published: May 2024

Glioblastoma, the most aggressive and challenging brain tumor, is a key focus in neuro-oncology due to its rapid growth and poor prognosis. The C6 glioma cell line is often used as a glioblastoma model due to its close simulation of human glioma characteristics, including rapid expansion and invasiveness. Alongside, herbal medicine, particularly Artemisia spp., is gaining attention for its anticancer potential, offering mechanisms like apoptosis induction, cell cycle arrest, and the inhibition of angiogenesis. In this study, we optimized extraction conditions of polyphenols from Artemisia annua L. and Artemisia vulgaris L. herbs and investigated their anticancer effects in silico and in vitro. Molecular docking of the main phenolic compounds of A. annua and A. vulgaris and potential target proteins, including programmed cell death (apoptosis) pathway proteins proapoptotic Bax (PDB ID 6EB6), anti-apoptotic Bcl-2 (PDB ID G5M), and the necroptosis pathway protein (PDB ID 7MON), mixed lineage kinase domain-like protein (MLKL), in complex with receptor-interacting serine/threonine-protein kinase 3 (RIPK3), revealed the high probability of their interactions, highlighting the possible influence of chlorogenic acid in modulating necroptosis processes. The cell viability of rat C6 glioma cell line was assessed using a nuclear fluorescent double-staining assay with Hoechst 33342 and propidium iodide. The extracts from A. annua and A. vulgaris have demonstrated anticancer activity in the glioblastoma model, with the synergistic effects of their combined compounds surpassing the efficacy of any single compound. Our results suggest the potential of these extracts as a basis for developing more effective glioblastoma treatments, emphasizing the importance of further research into their mechanisms of action and therapeutic applications.
Metabolic Analysis and Renal Protective Effects of Linagliptin and Empagliflozin in Alport Syndrome
Authors: Ge Mengyuan , Molina Judith , Tamayo Ian , Zhang Guanshi , Kim Jin-Ju , Njeim Rachel , Fontanesi Flavia , Pieper Michael Paul , Merscher Sandra , Sharma Kumar , Fornoni Alessia 
Published: May 2024

Key Points

Linagliptin reduces kidney function decline and extends lifespan in Alport syndrome mice.Inhibiting the generation of glucose metabolites could serve as a potential therapeutic strategy for the treatment of Alport syndrome.

Background
We previously demonstrated that empagliflozin (Empa), a sodium-glucose cotransporter-2 inhibitor, reduces intrarenal lipid accumulation and slows kidney function decline in experimental Alport syndrome (AS). In this study, we aimed to evaluate the renal protective benefits of linagliptin (Lina), a dipeptidyl peptidase-4 inhibitor in AS, and compare it with Empa.

Methods
Metabolite distribution in kidney cortices was assessed using mass spectrometry imaging. We examined albuminuria and histological changes in kidneys from AS mice treated with Lina and/or Empa or vehicle.

Results
Several metabolites, including adrenic acid and glucose, were increased in renal cortices of AS mice compared with wild-type (WT) mice, whereas eicosapentaenoic acid levels were decreased. In addition, a redistribution of adrenic acid from the glomerular compartment in WT mice to the tubulointerstitial compartment in AS mice was observed. Both Lina and Empa treatments were found to reduce albuminuria to extend the survival of AS mice for about 10 days and to decrease glomerulosclerosis and tubulointerstitial fibrosis compared with WT mice. There were no significant differences with regard to the renal phenotype observed between Empa- and Lina-treated AS mice, and the combination of Lina and Empa was not superior to individual treatments. In vitro experiments revealed that dipeptidyl peptidase-4 is expressed in podocytes and tubular cells derived from both AS and WT mice. Differently from what we have reported for Empa, Lina treatment was found to reduce glucose-driven respiration in AS tubular cells but not in AS podocytes.

Conclusions
Renal expression patterns and spatial distribution of several metabolites differ in AS compared with WT mice. Although Lina and Empa treatments similarly partially slow the progression of kidney disease in AS, the metabolic mechanisms conferring the protective effect may be different.
Un balance de los estudios de la simbología de las montañas en los Andes
Authors: Arroyo Sabino 
Published: May 2024

Los estudios del comportamiento religioso de los pueblos an- dinos aún no logran concitar trabajos en profundidad a los especialistas de la ciencia social, debido al preconcepto académico del «panteón de los dioses andinos» y por el contex- to del proceso de desacralización urbana de nuestro tiempo. No obstante, algunos lograron elucidar las fórmulas rituales y las expresiones del mito como componentes e improntas del sistema religioso en acción. Y, en cuanto son hechos so- ciales, están relacionadas a las capacidades productivas, a los sentimientos sociales y al sistema de valores de su entorno. Con esta preocupación nos proponemos mostrar un limitado sumario bibliográfico de aportes conceptuales, avances teóricos y registros etnográficos del pensamiento religioso andino contemporáneo. Partiendo de nuestra experiencia en la regiónde Ayacucho sobre el manejo conceptual del pagapu y wamani como ejes rituales de propiciación y núcleos duros de matrizcultural, en un contexto de los movimientos migratorios y de los conflictos sociales crecientes.
La prévision à moyenne échéance de la tempête Ciaràn par intelligence artificielle
Authors: Pardé Mickaël , Raynaud Laure , Mounier Arnaud 
Published: May 2024

Depuis un an environ, les performances des modèles de prévision du temps basés sur les réseaux de neurones sont devenues suffisamment intéressantes pour que les prévisionnistes commencent à les considérer. À l'occasion du passage de la tempête Ciaràn sur l'ouest de la France, nous évaluons les qualités et les défauts de quatre d'entre eux : GraphCast (Google Deepmind), Pangu-Weather (Huawei), AIFS (Centre européen pour les prévisions météorologiques à moyen terme, CEPMMT) et FourCastNet (Nvidia). Nous montrons que, loin encore de la prévision opérationnelle, les modèles de prévision par intelligence artificielle proposent des informations très pertinentes pour anticiper les tempêtes violentes.
Over the past year or so, the performance of neural network-based weather forecasting models has progressed significantly and began to attract the interest of forecasters. At the occasion of the passage of the Ciaràn storm over western France, we evaluate the strengths and shortcomings of four of them: GraphCast (Google Deepmind), Pangu-Weather (Huawei), AIFS (European Center for Medium-Range Weather Forecasts, ECMWF) and FourCastNet (NvIDIA). We show that, although far from being operational, artificial intelligence-based forecasting models are able to propose useful information to anticipate damaging storms.
Going back to “basics”: Harlow’s learning set task with wolves and dogs
Authors: Rivas-Blanco Dániel , Monteiro Tiago , Virányi Zsófia , Range Friederike 
Published: May 2024

AbstractTo survive and reproduce, animals need to behave adaptively by adjusting their behavior to their environment, with learning facilitating some of these processes. Dogs have become a go-to model species in comparative cognition studies, making our understanding of their learning skills paramount at multiple levels, not only with regards to basic research on their cognitive skills and the effects of domestication, but also with applied purposes such as training. In order to tackle these issues, we tested similarly raised wolves and dogs in a serial learning task inspired by Harlow’s “learning set.” In Phase 1, different pairs of objects were presented to the animals, one of which was baited while the other was not. Both species’ performance gradually improved with each new set of objects, showing that they “learnt to learn,” but no differences were found between the species in their learning speed. In Phase 2, once subjects had learned the association between one of the objects and the food reward, the contingencies were reversed and the previously unrewarded object of the same pair was now rewarded. Dogs’ performance in this task seemed to be better than wolves’, albeit only when considering just the first session of each reversal, suggesting that the dogs might be more flexible than wolves. Further research (possibly with the aid of refined methods such as computer-based tasks) would help ascertain whether these differences between wolves and dogs are persistent across different learning tasks.
Tools and methods to study and replicate experiments addressing human social cognition in interactive scenarios
Authors: Marchesi Serena , De Tommaso Davide , Kompatsiari Kyveli , Wu Yan , Wykowska Agnieszka 
Published: May 2024

AbstractIn the last decade, scientists investigating human social cognition have started bringing traditional laboratory paradigms more “into the wild” to examine how socio-cognitive mechanisms of the human brain work in real-life settings. As this implies transferring 2D observational paradigms to 3D interactive environments, there is a risk of compromising experimental control. In this context, we propose a methodological approach which uses humanoid robots as proxies of social interaction partners and embeds them in experimental protocols that adapt classical paradigms of cognitive psychology to interactive scenarios. This allows for a relatively high degree of “naturalness” of interaction and excellent experimental control at the same time. Here, we present two case studies where our methods and tools were applied and replicated across two different laboratories, namely the Italian Institute of Technology in Genova (Italy) and the Agency for Science, Technology and Research in Singapore. In the first case study, we present a replication of an interactive version of a gaze-cueing paradigm reported in Kompatsiari et al. (J Exp Psychol Gen 151(1):121–136, 2022). The second case study presents a replication of a “shared experience” paradigm reported in Marchesi et al. (Technol Mind Behav 3(3):11, 2022). As both studies replicate results across labs and different cultures, we argue that our methods allow for reliable and replicable setups, even though the protocols are complex and involve social interaction. We conclude that our approach can be of benefit to the research field of social cognition and grant higher replicability, for example, in cross-cultural comparisons of social cognition mechanisms.
Simultaneous Photometric and Spectroscopic Analysis of V505 Lacertae, a Photospherically and Chromospherically Active Contact Binary Star
Authors: Jeong Min-Ji , Kim Chun-Hwey , Hong Kyeongsoo , Kim Hye-Young , Song Mi-Hwa , Park Jang-Ho , Han Cheongho 
Published: May 2024

Abstract
New BVR photometric and high-resolution spectroscopic observations of V505 Lac are presented with Transiting Exoplanet Survey Satellite (TESS) photometric data. The orbital period has experienced a secular decrease during the past 16 yr. A clear anticorrelation in the primary and secondary eclipse timing variation (PSETV) obtained from the TESS data is also identified. A double-lined radial velocity (RV) curve is secured, and the effective temperatures of the less- and more-massive stars (Stars 1 and 2, respectively) are measured. Using a spectral subtraction technique, excess emissions are detected in the time-series Ca ii H and K and Hα lines for Star 2. Simultaneous analysis of the light and RV curves using the Wilson–Devinney (WD) code reveals that V505 Lac is a photospherically and chromospherically active W-subtype contact binary system. The component-star masses and radii are determined to an accuracy of approximately 1%. The WD spot model is individually applied to 221 light curves segmented from the TESS data so as to derive the spot parameters of a cool spot on Star 2. The combined variations in both longitude and colatitude among the spot parameters appear to be strongly associated with those of both the anticorrelation in the PSETV and the O’Connell effect in the TESS light curves. Robust negative linear relationships between the PSETV anticorrelation size and the O’Connell effect magnitude are found for the first time. Mass–radius, mass–luminosity, and mass ratio–mass diagrams of contact binaries, along with the mass ratio frequency distribution, are presented in an attempt to elucidate the evolutionary characteristics of these systems.