bluuebunny/crossref_metadata_2025_split huggingface dataset:
Aggressive Plaque Modification with Rotational Atherectomy and/or Cutting Balloon before Drug‐Eluting Stent Implantation for the Treatment of Calcified Coronary Lesions
Authors: VAQUERIZO BEATRIZ , SERRA ANTONIO , MIRANDA FAUSTINO , TRIANO JOSÉ LUIS , SIERRA GILBERTO , DELGADO GUILLERMO , PUENTES ANGEL , MOJAL SERGI , BRUGERA JORDI 
Published: June 2010

Introduction: Calcified coronary lesions may be associated with stent underexpansion, malapposition, and high rates of restenosis. The use of drug‐eluting stents (DES) in such lesions has not been fully addressed in the major trials. We sought to examine the outcomes of patients who were treated with plaque modification (PM) to facilitate DES implantation.
Methods: We analyzed 164 calcified coronary lesions in 145 consecutive patients who underwent aggressive PM with either rotational atherectomy (RA) and/or cutting balloon (CB) before DES implantation. CB was used in moderate calcified lesions and RA alone or followed by CB in severe calcified lesions.
Results: Patients were 68.7 ± 10.1 years old, 47% were diabetic, 34% had left ventricular ejection fraction (LVEF) ≤50%, and 39% had 3‐vessel disease. Ninety‐five percent of lesions were classified as B2/C, 100% as moderately/severely calcified. PM was achieved by using CB in 57% and by RA alone or followed by CB in 43%. In 100%, a DES was implanted. There was no failure to deliver a stent. At 15 ± 11 months follow‐up, the overall major adverse cardiac events (MACE) rate was 9.6% (3.4% cardiac death, 2.3% myocardial infarction, and 3.4% target lesion revascularization [TLR]). The only independent predictor of MACE was LVEF ≤50% (odds ratio 3.88; 95% confidence interval: 1.15–13.1; P = 0.03). The incidence of stent thrombosis (ST) was 2.1%. There were no significant differences in MACE and TLR based on the type of PM used.
Conclusions: In this population at high risk of restenosis, aggressive PM by CB and/or RA before DES implantation provides excellent mid‐term outcomes with only 3.4% TLR and 2.1% ST. (J Interven Cardiol 2010;23:240–248)
An Enhanced Device for Transluminal Retrieval of Vascular Stents Without Surgical Procedures: Experimental Studies
Authors: TSUCHIDA MASAYUKI , KAWASHIRI MASA‐AKI , UCHIYAMA KATSUHARU , SAKATA KENJI , NAKANISHI CHIAKI , TSUBOKAWA TOSHINARI , TAKABATAKE SHU , KONNO TETSUO , INO HIDEKAZU , YAMAGISHI MASAKAZU 
Published: June 2010

Background: Although efforts have been focused on developing endovascular procedures by which intravascular devices such as stents could be effectively deployed, few data exist regarding devices for the nonsurgical retrieval of deployed stents. Therefore, we designed to enable retrieval of deployed stents without a surgical procedure.
Methods: The device consisted of four components: ultra‐low profile forceps with 2.0 mm in diameter, conducting shaft with 1.8 mm in diameter, control handle by which the forceps is opened or closed, and a covering sheath. This device was designed to advance into the vessel lumen along a 0.014‐inch guidewire by over the wire fashion.
Results: The forceps could firmly catch nonexpanded as well as expanded tubular‐type stents with open cells in an in vitro model that was 4.0 mm in diameter. Then, we used this device in porcine renal arteries with 2.5–5.0 mm in diameter. At first, a fragmented 0.014‐inch guidewire could be safely removed without vessel damage that was confirmed by intravascular ultrasound. This device could successfully remove four of five inappropriately and 11 of 14 appropriately deployed stents. Under these conditions, intravascular ultrasound demonstrated minor vessel wall dissection in two‐third of cases.
Conclusions: These results demonstrate that the present device can be used for transluminal removal of foreign bodies such as nonexpanded as well as expanded stents in acute phase. Further miniaturization may enable using this type of device in the renal as well as coronary arteries. (J Interven Cardiol 2010;23:264–270)
The Association of Serum Uric Acid Levels with Outcomes Following Percutaneous Coronary Intervention
Authors: SPOON DANIEL B. , LERMAN AMIR , RULE ANDREW D. , PRASAD ABHIRAM , LENNON RYAN J. , HOLMES DAVID R. , RIHAL CHARANJIT S. 
Published: June 2010

Background: Serum uric acid may serve as a marker for the activation of oxidative stress and may therefore be a marker for subsequent cardiovascular events. Our goal was to assess the association of serum uric acid levels and the outcomes of patients who have undergone percutaneous coronary intervention (PCI).
Methods: We performed a retrospective cohort study of patients who underwent PCI between 1/1/2000 and 12/31/2007. Data were retrieved from the Cardiac Lab Interventional Clinical Database as well as the medical records. Outcomes of mortality as well as major adverse cardiac events (MACE) that include death, myocardial infarction (MI), and target vessel revascularization were obtained. There were 10,632 unique patients who had a PCI at the Mayo Clinic in Rochester and allowed use of their records for research. During this time, 1,916 had a uric acid measure within 2 years prior to the day of PCI.
Results: Of the 1,916 patients in our cohort, 1,353 had normal uric acid levels and 563 had elevated uric acid. After multivariable analysis, there was a strong trend in association with follow‐up mortality in patients with elevated uric acid (HR = 1.25, 95% CI 0.98–1.59, P = 0.07). The association with mortality or MI (HR = 1.15, 95% CI 0.93–1.43, P = 0.20) and the association with MACE (HR = 1.04, CI 0.86– 1.25, P = 0.71) were not significant.
Conclusions: In a large single‐center database with complete follow‐up, elevated serum uric acid was associated with increased mortality in PCI patients. These data show a trend for uric acid in the pathophysiology of atherosclerotic coronary artery disease and highlight the need for further research. (J Interven Cardiol 2010;23:277–283)
Transient Neurological Symptoms During Contrast Transcranial Doppler Right‐to‐Left Shunt Testing in Patients with Cryptogenic Neurological Disease
Authors: SORENSEN SHERMAN G. , AGUILAR HEATHER , REICHERT WALTER , GOLDSTEIN MICHAEL , THOEN DENNIS , THOMAS HEIDI , MUHLESTEIN JOSEPH B. 
Published: June 2010

Background: Paradoxical embolization from right‐to‐left shunt (RLS) resulting in neurological events is well described and patients with cryptogenic neurological disease are commonly evaluated for this condition. In the course of testing for RLS by bubble contrast transcranial Doppler (TCD), we observed that some patients developed transient neurological symptoms. This report describes our findings.
Methods: We performed diagnostic TCD on 445 consecutive patients with cryptogenic neurological disease (cerebral vascular accident, 21%; transient ischemic attack, 30%; migraine, 48%; and abnormal magnetic resonance brain imaging, 68%). Immediately following the procedure, patients were questioned about neurological symptoms.
Results: One hundred and sixty‐three (37%) of the 445 patients had absent or minimal shunting (Spencer grades 0–1) and 233 of 445 (52%) had severe RLS (Spencer grades 4–5+). One or more TCD‐associated neurological symptoms (TCD‐SX) developed in 95 of 445 (21%) of the patients. Compared to patients with absent or minimal shunting, patients with shunt grades 2–5+ were two and one half times more likely to develop TCD‐SX (18/164 [11%] vs. 77/283 [27%], P < 0.001). TCD‐SX were fourfold more common among patients with a history of migraine compared to history‐negative subjects (35 vs. 8.7%, P < 0.0001).
Conclusions: Diagnostic bubble‐contrast TCD provoked transient neurological symptoms. The symptoms correlated with the severity of RLS and were more common in migraine patients, suggesting that migraine patients are sensitized to chemical and/or microembolic shunt factors. There was no significant residual morbidity, and bubble‐contrast echocardiograph continues to be a safe and valuable diagnostic procedure. (J Interven Cardiol 2010;23:284–290)
Dubai Camel Market Transnational Workers: An Ethnographic Portrait
Authors: KHALAF SULAYMAN N. 
Published: June 2010

AbstractThe paper presents an ethnographic documentation of life conditions and work patterns of transnational camel workers in the UAE. The ethnographic evidence presented is based on field work carried out in 2005 in Dubai Nad Al‐Sheba camel market and in the adjacent camel racetrack and camel farms. Intermittent field visits were also carried out during 2007and 2008. The data is presented in the form of short synopses of kin‐related workers who come from Asian and Arab countries, such as Pakistan, Sudan and Syria. The main thesis of this study revolves around how members of the various ethnic groups working in the market managed in spite of the transitory, precarious and underclass globalized life conditions at the margins of Dubai city to reconstruct numerous aspects of their local communities. They activated traditional multiplex relationships as survival mechanisms. These included the utilization of traditional social capital, symbiotic economic networks, family nesting, kinship bonding and mutual support for fellow ethnic migrants. Locality here is equated with the activation of village/tribal social habitus.
Home range and seasonal movement of taimen, Hucho taimen, in Mongolia
Authors: Gilroy D. J. , Jensen O. P. , Allen B. C. , Chandra S. , Ganzorig B. , Hogan Z. , Maxted J. T. , Vander Zanden M. J. 
Published: June 2010

Gilroy DJ, Jensen OP, Allen BC, Chandra S, Ganzorig B, Hogan Z, Maxted JT, Vander Zanden MJ. Home range and seasonal movement of taimen, Hucho taimen, in Mongolia. Ecology of Freshwater Fish 2010: 19: 545–554. © 2010 John Wiley & Sons A/SAbstract – Taimen, Hucho taimen, is the world’s largest salmonid and a prized sport fish. We used radio and acoustic telemetry to characterise movements of adult taimen in an extensive river system, the Eg–Uur, in north‐central Mongolia. Forty‐six taimen were tagged with transmitters (27 radio, 17 acoustic and 2 radio‐acoustic combined) and tracked from 2004 to 2008 using mobile surveys and fixed receivers. The mean home range of individual taimen tracked for an average of 2.4 years was 23 km (N = 41, range = 0.5–93.2 km). Of the fish with over 10 relocations (N = 16), 90% remained within a range of 38 km. Four distinct movement patterns were observed: (i) restricted core home range, (ii) core range with seasonal departures, (iii) core range with separate seasonal range and (iv) home range transfer. Movement was greatest in May and June (spawning and postspawning period) with another peak period of movement in September and October (water temperature cooling).
Long‐term effects of growth hormone therapy on patients with Prader–Willi syndrome
Authors: Sipilä Ilkka , Sintonen Harri , Hietanen Heikki , Apajasalo Marjo , Alanne Soili , Viita Anna‐Mari , Leinonen Eeva 
Published: June 2010

AbstractAim:  To assess the effects of recombinant human growth hormone (rhGH) treatment in children with Prader–Willi syndrome.Design:  A 1‐year study and an observational follow‐up visit 10 years later.Methods:  In 20 patients with Prader–Willi syndrome (PWS): clinical assessment, laboratory tests, body composition analysis by dual energy X‐ray absorptiometry, sleep polygraphy, health‐related quality of life assessed by 16D.Results:  Only two patients had normal growth hormone secretion at baseline. All patients were significantly shorter than their expected heights, but experienced catch‐up growth during growth hormone treatment. At follow‐up, 13 patients had reached adult heights and were markedly taller than historical controls. The cumulative dose of rhGH over 10 years correlated inversely with the total body fat percentage (p = 0.033). However, patients remained severely obese at 10 years. Sleep polygraphy was abnormal in more than half of the patients. Health‐related quality of life of the patients remained substantially below that of normal population.Conclusion:  Growth hormone markedly improved adult height in subjects with PWS when compared to historical data. The cumulative dose of growth hormone correlated with reduction in body fat; nevertheless, patients remained severely obese.
Occurrence of vesicoureteral reflux in children
Authors: Venhola M , Hannula A , Huttunen N‐P , Renko M , Pokka T , Uhari M 
Published: June 2010

AbstractAim:  The reported low occurrence of vesicoureteral reflux in the general population seems implausible. We wanted to test the hypothesis that reflux is more common and more independent of urinary‐tract infection than has previously been thought.Methods:  We tested our hypothesis by analysing the characteristics of 406 consecutive children aged <5 years who had been referred for consultation because of urinary‐tract infection. Using data on their urine samples, we evaluated the reliability of the urinary‐tract infection diagnosis and analysed the frequencies of vesicoureteral reflux and abnormal ultrasound findings in three reliability groups (A: certain urinary‐tract infection, B: possible and C: improbable).Results:  The occurrence of reflux was the same irrespective of the diagnostic reliability of urinary‐tract infection (A: 98/276 [36%] versus B: 13/46 [28%] versus C: 9/25 [36%]). Most of the abnormal ultrasound findings (58/71, 80%) were found among patients with a certain diagnosis (Group A).Conclusion:  We suggest that vesicoureteral reflux is more common in children even without urinary‐tract infection than has been thought previously. The guidelines recommending a search for reflux by means of voiding cystourethrography should be reconsidered.
Morbidity associated with heroin overdose presentations to an emergency department: A 10‐year record linkage study
Authors: Fatovich Daniel M , Bartu Anne , Davis Geoff , Atrie Jag , Daly Frank FS 
Published: June 2010

AbstractIntroduction:  To examine hospitalizations in a cohort of 224 patients who presented with non‐fatal heroin overdose to an ED.Methods:  A record linkage study, using the morbidity, mental health and mortality databases in the Data Linkage Unit of the Department of Health, Western Australia. The main outcome measures were hospital separations 5 years before and after entry into the cohort.Results:  Before entry into the cohort, 199 (89%) patients had an admission to mental health services. These 199 had a combined total of 1367 separations, most commonly for a mental health condition, injury or poisoning. Women had more than twice the relative risk (RR) of men for all separations (RR 2.35, 95% confidence interval [CI] 1.96–2.82, P < 0.001) and for injury and poisoning separations (RR 2.04, 95% CI 1.56–2.66, P < 0.001). The highest concentrations of separations occurred within 1 year before and 1 year after entry into the cohort. There were 12 (5.4%, 95% CI 2.9–9.4%) deaths, most commonly from overdose.Conclusion:  Non‐fatal heroin overdose ED presentations are associated with a cluster of hospitalizations around that episode, likely to be related to heroin availability. Presentation to hospital by heroin users represents an opportunity to counsel less risky behaviour.
Microwave observations of spinning dust emission in NGC6946
Authors: Scaife Anna M. M. , Nikolic Bojan , Green David A. , Beck Rainer , Davies Matthew L. , Franzen Thomas M. O. , Grainge Keith J. B. , Hobson Michael P. , Hurley-Walker Natasha , Lasenby Anthony N. , Olamaie Malak , Pooley Guy G. , Rodríguez-Gonzálvez Carmen , Saunders Richard D. E. , Scott Paul F. , Shimwell Timothy W. , Titterington David J. , Waldram Elizabeth M. , Zwart Jonathan T. L. 
Published: June 2010

ABSTRACT
We report new cm-wave measurements at five frequencies between 15 and 18GHz of the continuum emission from the reportedly anomalous ‘region 4’ of the nearby galaxy NGC6946. We find that the emission in this frequency range is significantly in excess of that measured at 8.5GHz, but has a spectrum from 15 to 18GHz consistent with optically thin free–free emission from an ultracompact Hii region. In combination with previously published data, we fit four emission models containing different continuum components using the Bayesian spectrum analysis package radiospec. These fits show that, in combination with data at other frequencies, a model with a spinning dust component is slightly preferred to those that possess better-established emission mechanisms.
General Aspects and Neuropathology of X‐Linked Adrenoleukodystrophy
Authors: Ferrer Isidro , Aubourg Patrick , Pujol Aurora 
Published: June 2010

AbstractX‐adrenoleukodystrophy (X‐ALD) is a metabolic, peroxisomal disease affecting the nervous system, adrenal cortex and testis resulting from inactivating mutations inABCD1gene which encodes a peroxisomal membrane half‐adenosine triphosphate (ATP)‐binding cassette transporter, ABCD1 (or ALDP), whose defect is associated with impaired peroxisomal β‐oxidation and accumulation of saturated very long‐chain fatty acids (VLCFA) in tissues and body fluids. Several phenotypes are recognized in male patients including cerebral ALD in childhood, adolescence or adulthood, adrenomyeloneuropathy (AMN), Addison's disease and, eventually, gonadal insufficiency. Female carriers might present with mild to severe myeloneuropathy that resembles AMN. There is a lack of phenotype–genotype correlations, as the same ABCD1 gene mutation may be associated with different phenotypes in the same family, suggesting that genetic, epigenetic, environmental and stochastic factors are probably contributory to the development and course of the disease. Degenerative changes, like those seen in pure AMN without cerebral demyelination, are characterized by loss of axons and secondary myelin in the long tracts of the spinal cord, possibly related to the impaired lipid metabolism of VLCFAs and the associated alterations (ie, oxidative damage). Similar lesions are encountered following inactivation ofABCD1in mice (ABCD1‐). A different and more aggressive phenotype is secondary to cerebral demyelination, very often accompanied by inflammatory changes in the white matter of the brain and associated with activation of T lymphocytes, CD1 presentation and increased levels of cytokines, γ‐interferon, interleukin (IL)‐1α, IL‐2 and IL‐6, Granulocyte macrophage colony‐stimulating factor (GM‐CSF), tumor necrosis factor‐α, chemokines and chemokine receptors.
Current and Future Pharmacological Treatment Strategies in X‐Linked Adrenoleukodystrophy
Authors: Berger Johannes , Pujol Aurora , Aubourg Patrick , Forss‐Petter Sonja 
Published: June 2010

AbstractMutations in the ABCD1 gene cause the clinical spectrum of the neurometabolic disorder X‐linked adrenoleukodystrophy/adrenomyeloneuropathy (X‐ALD/AMN). Currently, the most efficient therapeutic opportunity for patients with the cerebral form of X‐ALD is hematopoietic stem cell transplantation and possibly gene therapy of autologous hematopoietic stem cells. Both treatments, however, are only accessible to a subset of X‐ALD patients, mainly because of the lack of markers that can predict the onset of cerebral demyelination. Moreover, for female or male X‐ALD patients with AMN, currently only unsatisfying therapeutic opportunities are available. Thus, this review focuses on current and urgently needed future pharmacological therapies. The treatment of adrenal and gonadal insufficiency is well established, whereas applications of immunomodulatory and immunosuppressive drugs have failed to prevent progression of cerebral neuroinflammation. The use of Lorenzo's oil and the inefficacy of lovastatin to normalize very‐long‐chain fatty acids in clinical trials as well as currently experimental and therefore possible future therapeutic strategies are reviewed. The latter include pharmacological gene therapy mediated by targeted upregulation of ABCD2, the closest homolog of ABCD1, antioxidative drug treatment, small molecule histone deacetylase inhibitors such as butyrates and valproic acid, and other neuroprotective attempts.
Life cycle analysis of the model organism Rhodopirellula baltica SH 1T by transcriptome studies
Authors: Wecker Patricia , Klockow Christine , Schüler Margarete , Dabin Jérôme , Michel Gurvan , Glöckner Frank O. 
Published: June 2010

SummaryThe marine organism Rhodopirellula baltica is a representative of the globally distributed phylum Planctomycetes whose members exhibit an intriguing lifestyle and cell morphology. The analysis of R. baltica's genome has revealed many biotechnologically promising features including a set of unique sulfatases and C1‐metabolism genes. Salt resistance and the potential for adhesion in the adult phase of the cell cycle were observed during cultivation. To promote the understanding of this model organism and to specify the functions of potentially useful genes, gene expression throughout a growth curve was monitored using a whole genome microarray approach. Transcriptional profiling suggests that a large number of hypothetical proteins are active within the cell cycle and in the formation of the different cell morphologies. Numerous genes with potential biotechnological applications were found to be differentially regulated, revealing further characteristics of their functions and regulation mechanisms. More specifically, the experiments shed light on the expression patterns of genes belonging to the organism's general stress response, those involved in the reorganization of its genome and those effecting morphological changes. These transcriptomic results contribute to a better understanding of thus far unknown molecular elements of cell biology. Further, they pave the way for the biotechnological exploitation of R. baltica's distinctive metabolic features as a step towards sourcing the phylum Planctomycetes at large.
Identification of Novel Mutations in RBM20 in Patients with Dilated Cardiomyopathy
Authors: Li Duanxiang , Morales Ana , Gonzalez‐Quintana Jorge , Norton Nadine , Siegfried Jill D. , Hofmeyer Mark , Hershberger Ray E. 
Published: June 2010

AbstractThe genetic basis of most of dilated cardiomyopathy (DCM) cases remains unknown. A recent study indicated that mutations in a highly localized five amino acid hotspot in exon 9 of RBM20, a gene encoding a ribonucleic acid‐binding protein, caused aggressive DCM. We undertook this study to confi rm and extend the nature of RBM20 mutations in another DCM cohort. Clinical cardiovascular data, family histories, and blood samples were collected from patients with idiopathic DCM. DNA from 312 DCM probands was sequenced for nucleotide alterations in exons 6 through 9 of RBM20, and additional family members as possible. We found six unique RBM20 rare variants in six unrelated probands (1.9%). Four mutations, two of which were novel (R634W and R636C) and two previously identified (R634Q and R636H), were identified in a five amino acid hotspot in exon 6. Two other novel variants (V535I in exon 6 and R716Q in exon 9) were outside of this hotspot. Age of onset and severity of heart failure were variable, as were arrhythmias and conduction system defects, but many subjects suffered severe heart failure resulting in early death or cardiac transplantation. This article concludes that DCM in patients with RBM20 mutations is associated with advanced disease. Clin Trans Sci 2010; Volume 3: 90–97