bluuebunny/crossref_metadata_2025_split huggingface dataset:
The selective determination of sulfates, sulfonates and phosphates in urine by CE‐MS
Authors: Bunz Svenja‐Catharina , Weinmann Wolfgang , Neusüß Christian 
Published: March 2010

AbstractMetabolite identification and metabolite profiling are of major importance in the pharmaceutical and clinical context. However, highly polar and ionic substances are rarely included as analytical tools are missing. In this study, we present a new method for the determination of urinary sulfates, sulfonates, phosphates and other anions of strong acids. The method comprises a CE separation using an acidic BGE (pH≤2) and anodic detection by MS via negative ESI. In this way, only sulfates and sulfonates are detected in the first part of the electropherogram, followed by phosphates and potentially highly acidic carboxylates. The selectivity for sulfur‐containing species is proved using extracted ion electropherograms based on certain isotopic ratios. Ethyl sulfate can be determined by this method and, thus, CE‐MS can be used for determination of this alcohol consumption marker. An SPE method was developed for the extraction of ethyl sulfate and other organic anions. Several additional compounds can be identified based on the accurate mass determined by the TOF MS in conjunction with databases. However, numerous detected compounds have not been reported in urinary metabolite databases so far. Thus, it is demonstrated that the presented method is complementary to the existing methods for metabolite characterization in urine.
Repair of DNA interstrand cross‐links during S phase of the mammalian cell cycle
Authors: Legerski Randy J. 
Published: March 2010

AbstractDNA interstrand cross‐linking (ICL) agents are widely used in anticancer chemotherapy regimens, yet our understanding of the DNA repair mechanisms by which these lesions are removed from the genome remains incomplete. This is at least in part due to the enormously complicated nature and variety of the biochemical pathways that operate on these complex lesions. In this review, we have focused specifically on the S‐phase pathway of ICL repair in mammalian cells, which appears to be the major mechanism by which these lesions are removed in cycling cells. The various stages and components of this pathway are discussed, and a putative molecular model is presented. In addition, we propose an explanation as to how this pathway can lead to the observed high levels of sister chromatid exchanges known to be induced by ICLs. Environ. Mol. Mutagen., 2010. © 2010 Wiley‐Liss, Inc.
Mammalian nucleotide excision repair proteins and interstrand crosslink repair
Authors: Wood Richard D. 
Published: March 2010

AbstractAlthough various schemes for interstrand crosslink (ICL) repair incorporate DNA recombination, replication, and double‐strand break intermediate steps, action of the nucleotide excision repair (NER) system or some variation of it is a common feature of most models. In the bacterium Escherichia coli, the NER enzyme UvrABC can incise on either side of an ICL to unhook the crosslink, and can proceed via a subsequent recombination step. The relevance of NER to ICL repair in mammalian cells has been challenged. Of all NER mutants, it is clear that ERCC1 and XPF‐defective cells show the most pronounced sensitivities to ICL‐inducing agents, and defects in ICL repair. However, there is good evidence that cells defective in NER proteins including XPA and XPG are also more sensitive than normal to ICL‐inducing agents. These results are summarized here, together with evidence for defective crosslink removal in NER‐defective cells. Studies of incision at sites of ICL by cell extracts and purified proteins have been done, but these studies are not all consistent with one another and further research is required. Environ. Mol. Mutagen., 2010. © 2010 Wiley‐Liss, Inc.
What's in a name? Brain activity reveals categorization processes differ across languages
Authors: Liu Chao , Tardif Twila , Mai Xiaoqin , Gehring William J. , Simms Nina , Luo Yue‐Jia 
Published: March 2010

AbstractThe linguistic relativity hypothesis proposes that speakers of different languages perceive and conceptualize the world differently, but do their brains reflect these differences? In English, most nouns do not provide linguistic clues to their categories, whereas most Mandarin Chinese nouns provide explicit category information, either morphologically (e.g., the morpheme “vehicle” che1 in the noun “train” huo3che1 ) or orthographically (e.g., the radical “bug” chong2 in the character for the noun “butterfly” hu2die2 ). When asked to judge the membership of atypical (e.g., train) vs. typical (e.g., car) pictorial exemplars of a category (e.g., vehicle), English speakers (N = 26) showed larger N300 and N400 event‐related potential (ERP) component differences, whereas Mandarin speakers (N = 27) showed no such differences. Further investigation with Mandarin speakers only (N = 22) found that it was the morphologically transparent items that did not show a typicality effect, whereas orthographically transparent items elicited moderate N300 and N400 effects. In a follow‐up study with English speakers only (N = 25), morphologically transparent items also showed different patterns of N300 and N400 activation than nontransparent items even for English speakers. Together, these results demonstrate that even for pictorial stimuli, how and whether category information is embedded in object names affects the extent to which typicality is used in category judgments, as shown in N300 and N400 responses. Hum Brain Mapp, 2010. © 2010 Wiley‐Liss, Inc.
Synthesis, aggregation properties, and antiprotozoal activity of heterocyclic heterogemini surfactants
Authors: Lukáč M. , Timko L. , Mrva M. , Ondriska F. , Karlovská J. , Valentová J. , Lacko I. 
Published: March 2010

AbstractA series of four heterogemini surfactants have been synthesized: 2‐decyl [dodecyl(dimethyl)ammonio]ethyl phosphate, decyl 2‐(1‐dodecylpyrrolidinio‐1‐yl)ethyl phosphate, decyl 2‐(1‐dodecylpiperidinio‐1‐yl)ethyl phosphate, and decyl 2‐(1‐dodecylmorpholinio‐1‐yl)ethyl phosphate. Antiprotozoal activity of prepared compounds against Acanthamoeba lugdunensis was investigated. Decyl 2‐(1‐dodecylpyrrolidinio‐1‐yl)ethyl phosphate exhibited the best trophocidal activity. The activities of heterogemini surfactants were compared with their aggregation properties. © 2010 Wiley Periodicals, Inc. 21:203–209, 2010; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/hc.20587
A concise synthesis of sex pheromone of mediterranean fruit fly, Ceratitis capitata via lithiated carbanion derived from enephosphoramide
Authors: Krzysztof Olszewski Tomasz , Grison Claude 
Published: March 2010

AbstractA novel and versatile synthetic approach to the preparation of (E)‐non‐6‐en‐1‐ol, a sex pheromone of the Mediterranean fruit fly, Ceratitis capitata, is presented. This pheromone can be viewed as potential active component for lures designed to control and eradication of Mediterranean fruit fly. The described protocol is a six‐step reaction sequence producing the desired compound with 28% overall yield from commercially available and inexpensive starting material and total E stereoselectivity of the double bond present in final structure. The key to the success of the presented strategy is application of lithiated α‐allylphosphoramido carbanions and their reaction with halogenated acetals. © 2010 Wiley Periodicals, Inc. 21:139–147, 2010; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/hc.20588
An impact evaluation of the Safe Motherhood Program in China
Authors: Feng Xing Lin , Shi Guang , Wang Yan , Xu Ling , Luo Hao , Shen Juan , Yin Hui , Guo Yan 
Published: March 2010

AbstractUsing 11 years of county‐level panel data, fixed effect models are estimated to evaluate the impact of the Safe Motherhood (SM) Program in China. Propensity score matching is used to select comparable factual and counterfactual counties. Out of 2013 counties in China, 283 are selected for the treatment group and 1051 for the control group. The results support the causal relationship between the program and its targeted outcomes and the partial effects increases as years of exposure in the program: 7 years' treatment of the program increases hospital delivery rate by 3.992 per 100 live births and decreases Maternal mortality ratio (MMR) due to hemorrhage by 10.229 per 100 000 live births. Further modeling supports the conclusion that the program reduces MMR by enhancing MCH care. With an average annual incremental unit cost for the program of about 318.0 thousand RMB (39.8 thousand USD) per county, we conclude that the SM Program is effective in reducing MMR through the enhancement of hospital delivery. Copyright © 2010 John Wiley & Sons, Ltd.
Utility of TL‐201 SPECT in clarifying false‐positive FDG‐PET findings due to osteoradionecrosis in head and neck cancer
Authors: Wang Chih‐Hsiu , Liang Ji‐An , Ding Hueisch‐Jy , Yang Shih‐Neng , Yen Kuo‐Yang , Sun Shung‐Shung , Kao Chia‐Hung 
Published: March 2010

AbstractBackgroundThis study aimed to determine whether Tl‐201 single photon emission CT (SPECT) is potentially useful in differentiating false‐positive fluorodeoxyglucose positron emission tomography (FDG‐PET) findings caused by osteoradionecrosis (ORN) from recurrent head and neck cancer after radiotherapy.MethodsFive patients were recruited. Dual‐phase FDG‐PET and dual‐phase Tl‐201 SPECT were performed for each patient.ResultsAll 5 patients proved to have ORN without recurrent cancer. By visual interpretation, the results were 4 positive versus 1 negative for PET, and 4 negative versus 1 positive for Tl‐201 SPECT. The Tl‐201 SPECT clarified 3 of the 4 false‐positive PETs to be ORN. Dual‐phase semiquantitative studies showed decreased standardized uptake value (SUV) over time in 3 of the 4 false‐positive PETs and decreased lesion/background ratio over time in the false‐positive Tl‐201 SPECT.ConclusionThe Tl‐201 SPECT may help clarify suspected false‐positive FDG uptake caused by ORN. Dual‐phase FDG‐PET and dual‐phase Tl‐201 SPECT may also have some value. © 2010 Wiley Periodicals, Inc. Head Neck, 2010
Diagnostic accuracy of fine‐needle aspiration cytology in Warthin tumors
Authors: Veder Laura L. , Kerrebijn Jeroen D.F. , Smedts Frank M. , den Bakker Michael A. 
Published: March 2010

AbstractBackgroundOur aim was to evaluate the diagnostic accuracy of fine‐needle aspiration cytology (FNAC) for Warthin tumors of the parotid gland.MethodsAll cytologic diagnoses of Warthin tumor between 1990 and 2007 were correlated with available histology. In addition, our results were compared to current literature.ResultsIn 310 cases, Warthin tumor was diagnosed by FNAC. In 133 cases, (43%) both cytology and histology were available. In 127 of these 133 cases (95.5%), the diagnosis Warthin tumor was confirmed by histology. In 4 cases (3%), a benign lesion was diagnosed and 2 (1.5%) revealed a malignant lesion. On review, those cytologic diagnoses were not certain. In the literature, 11 missed malignancies (5.4%) in 202 cases were reported.ConclusionThe diagnostic accuracy of FNAC for the diagnosis of Warthin tumor is high and the percentage of missed malignant tumors is very low. Our results imply that a cytologic diagnosis of Warthin tumor may justify conservative treatment. © 2010 Wiley Periodicals, Inc. Head Neck, 2010
Effective work‐life balance support for various household structures
Authors: ten Brummelhuis Lieke L. , van der Lippe Tanja 
Published: March 2010

AbstractToday's workforce encompasses a wide variety of employees with specific needs and resources when it comes to balancing work and life roles. Our study explores whether various types of work‐life balance support measures improve employee helping behavior and performance among single employees, employees with a partner, and employees with a partner and children. Using a sample of 482 employees at 24 organizations, the results showed that the organization's work‐family culture improved work performance among parents but reduced performance among singles. Singles' work outcomes improved, however, when they had access to flexible work arrangements, whereas couples benefited from their supervisors' social support. The results stress the importance of the employee's household structure when considering appropriate support for balancing work and life roles. © 2010 Wiley Periodicals, Inc.
Human resource management practices affecting unit managers in franchise networks
Authors: Castrogiovanni Gary J. , Kidwell Roland E. 
Published: March 2010

AbstractFranchising is an important context in studying entrepreneurship and a growing area of business activity worldwide. To date, various studies have considered the strategic implications of decisions to retain firm ownership of particular units or to franchise them. Little attention, however, has focused on the differences between employee or franchisee managers of those units. We address this gap in the literature by offering a perspective on human resource management (HRM) and franchising that considers those differences, thus providing a bridge between the HRM and franchising fields of inquiry. © 2010 Wiley Periodicals, Inc.
Linking HR formality with employee job quality: The role of firm and workplace size
Authors: Storey David J. , Saridakis George , Sen‐Gupta Sukanya , Edwards Paul K. , Blackburn Robert A. 
Published: March 2010

AbstractThe process of managing a small firm differs from managing a large firm, because small firms face distinct forms of risk and organize their human resources differently, often informally (Kotey & Slade, 2005; Storey, 2002). This paper introduces and tests a new variable, self‐reported job quality (SRJQ), as a key link in the causal chain between HR practices and outcomes. In comparing small firms with large ones, we present three key findings: (1) employee reports of job quality are highest in small firms and decrease as firm size increases; (2) in workplaces owned by large firms, job quality is highest in the smallest workplaces; and (3) workers in small workplaces owned by large firms report lower job quality than workers in comparable sized workplaces owned by small firms. Our findings are partially explained by how formally HR practices are implemented. We show that formality increases with firm size and workplace size. Importantly, evidence suggests that employing an HR professional (a key indicator of HR formality) lowers SRJQ in single‐site SMEs. Implications for small business owners, HR professionals in large and small firms, and policy makers are discussed. © 2010 Wiley Periodicals, Inc.
Historical discharge measurements on the Middle Mississippi River, USA: no basis for ‘changing history’
Authors: Pinter Nicholas 
Published: March 2010

AbstractThis study tests the hypothesis that historical float‐based discharge measurements on the Mississippi River systematically over‐stated actual flood flows by 10% to > 30% relative to measurements using current meters. This assertion has been repeated over the past 25 years and recently has been used to adjust historical discharges used for flood‐frequency analysis. This study tests the hypothesis above using 2150 historical discharge measurements digitized from the three principal gauging stations on the Middle Mississippi River (MMR): data that include 626 float‐based discharges and 1516 meter‐based discharges, including 122 paired measurements. Multiple comparative tests show that the hypothesis above cannot be supported; if anything, the float‐based measurements slightly underestimate flows (not over‐estimate) over a broad range of discharges up to large floods. In response to the purported data bias above (‘changing history’; Dieckmann RJ, Dyhouse GR. 1998. Changing history at St. Louis—adjusting historic flows for frequency analysis. First Federal Inter‐Agency Hydrologic Modeling Conference, April 20–22, 1998. Las Vegas, NV; 4·31–4·36), historical flood discharges on the MMR have been modified, most by 10–20% and several by > 30%. These altered discharges are now being promulgated, in particular, through the Upper Mississippi River System Flow Frequency Study (UMRSFFS). New flow frequencies, flood profiles, and new flood maps from the UMRSFFS may significantly underestimate the actual flood hazard on the MMR if the original hydrologic data have been erroneously altered on the basis of an assumption of data bias. Copyright © 2010 John Wiley & Sons, Ltd.
Aquatic hazard assessment for pharmaceuticals, personal care products, and endocrine-disrupting compounds from biosolids-amended land
Authors: Langdon KA , Warne MStJ , Kookana RS 
Published: March 2010

Abstract
Reuse of biosolids on agricultural land is a common practice. Following the application of biosolids to land, contaminants in the biosolids have the potential to migrate offsite via surface runoff and/or leaching and pose a hazard to aquatic ecosystems. The aim of this screening-level assessment study was to determine the relative hazard posed to aquatic ecosystems by pharmaceuticals, personal care products, and endocrine-disrupting compounds (EDCs) that have been detected and quantified in biosolids. This involved estimating maximum possible runoff water concentrations of compounds, using an equilibrium partitioning approach and then comparing these with the lowest available aquatic toxicity data, using the hazard quotient (HQ) approach. A total of 45 pharmaceuticals, personal care products, and EDCs have been detected in biosolids. Ten of these compounds (tonalide, galaxolide, 17β-estradiol, 17α-ethinylestradiol, ciprofloxacin, doxycycline, norfloxacin, ofloxacin, triclosan, and triclocarban) posed a high (HQ &gt;1.0) hazard to aquatic ecosystems relative to the other compounds. This hazard assessment indicated that further research into potential offsite migration and deleterious effects on aquatic ecosystems is warranted for the 10 organic contaminants identified, and possibly for chemicals with similar physicochemical and toxicological properties, in biosolids-amended soils. Because many antibiotic compounds (e.g., ciprofloxacin, norfloxacin, and ofloxacin) have ionic properties, the methods used may have overestimated their predicted aqueous concentrations and hazard. Further research that includes site-specific variables, e.g., dilution factors in waterways, rain intensity, slope of land, degradation, and the use of management strategies such as buffer zones, is likely to decrease the hazard posed by these high hazard compounds. Integr Environ Assess Manag 2010;6:663–676. © 2010 SETAC
Mössbauer spectroscopic studies of the six‐coordinate heme—nitric oxide complex of iron(III) octaethylporphyrin N‐methylimidazole, the first model of the nitrophorin—no complexes
Authors: Schünemann Volker , Benda Rüdiger , Trautwein Alfred X. , Walker F. Ann 
Published: March 2010

AbstractThe NO, N‐methylimidazole complex of isotopically enriched octaethylporphyrinatoiron(III) chloride, [OEP57Fe(NO)(N‐MeIm)+Cl− has been prepared in dimethylacetamide solution and studied by low‐temperature Mössbauer spectroscopy in the presence and absence of a magnetic field. This complex is a model for the Fe(III)‐NO complexes of the nitrophorins of the blood‐sucking insect, Rhodnius prolixus, where NO is released from the histidine‐coordinated ferrihemin center of each of the proteins upon the insect's injection of the saliva into the victim. The [OEPFe(NO)(N‐MeIm)]+Cl− complex is EPR silent and behaves as a diamagnetic species, with quadrupole splitting ΔEQ = 1.64 mm s−1, asymmetry parameter η = 0.4, isomer shift δ = 0.02 mm s−1, and linewidth Γ= 0.3 mm s−1. Two electron configurations, Fe(III)‐NO (low‐spin d5, strongly antiferromagnetically coupled to NO), or Fe(II)‐NO+ (low‐spin d6, purely diamagnetic), are possible. Which is the actual configuration cannot be determined until detailed molecular calculations are carried out. The low‐spin OEPFe(III)‐bis‐N‐methylimidazole complex also present in this sample has EPR g‐values, quadrupole splitting, isomer shift, and hyperfine splittings typical of rhombic low‐spin ferriheme centers.
Accuracy of high-resolution in vivo micro magnetic resonance imaging for measurements of microstructural and mechanical properties of human distal tibial bone
Authors: Liu X Sherry , Zhang X Henry , Rajapakse Chamith S , Wald Michael J , Magland Jeremy , Sekhon Kiranjit K , Adam Mark F , Sajda Paul , Wehrli Felix W , Guo X Edward 
Published: March 2010

Abstract
Micro magnetic resonance imaging (µMRI) is an in vivo imaging method that permits 3D quantification of cortical and trabecular bone microstructure. µMR images can also be used for building microstructural finite element (µFE) models to assess bone stiffness, which highly correlates with bone's resistance to fractures. In order for µMRI-based microstructural and µFE analyses to become standard clinical tools for assessing bone quality, validation with a current gold standard, namely, high-resolution micro computed tomography (µCT), is required. Microstructural measurements of 25 human cadaveric distal tibias were performed for the registered µMR and µCT images, respectively. Next, whole bone stiffness, trabecular bone stiffness, and elastic moduli of cubic subvolumes of trabecular bone in both µMR and µCT images were determined by voxel-based µFE analysis. The bone volume fraction (BV/TV), trabecular number (Tb.N*), trabecular spacing (Tb.Sp*), cortical thickness (Ct.Th), and structure model index (SMI) based on µMRI showed strong correlations with µCT measurements (r2 = 0.67 to 0.97), and bone surface-to-volume ratio (BS/BV), connectivity density (Conn.D), and degree of anisotropy (DA) had significant but moderate correlations (r2 = 0.33 to 0.51). Each of these measurements also contributed to one or many of the µFE-predicted mechanical properties. However, model-independent trabecular thickness (Tb.Th*) based on µMRI had no correlation with the µCT measurement and did not contribute to any mechanical measurement. Furthermore, the whole bone and trabecular bone stiffness based on µMRI were highly correlated with those of µCT images (r2 = 0.86 and 0.96), suggesting that µMRI-based µFE analyses can directly and accurately quantify whole bone mechanical competence. In contrast, the elastic moduli of the µMRI trabecular bone subvolume had significant but only moderate correlations with their gold standards (r2 = 0.40 to 0.58). We conclude that most microstructural and mechanical properties of the distal tibia can be derived efficiently from µMR images and can provide additional information regarding bone quality. © 2010 American Society for Bone and Mineral Research.