bluuebunny/crossref_metadata_2025_split huggingface dataset:
ChemInform Abstract: Asymmetric Cyclization Reactions of N‐Benzoyl‐α‐dehydroarylalanine Alkyl Esters via Photoinduced Electron Transfer from Achiral and Chiral Amines.
Authors: Sasaki Yuji , Watanabe Haruo , Igarashi Tetsutaro , Sakurai Tadamitsu 
Published: September 2011

AbstractThe photoinduced cyclization of chiral auxiliary‐substituted (Z)‐enamides (I) gives the diastereomeric forms of the cis‐ (II)/(III) and trans‐configured (IV)/(V) oxazole derivatives.
ChemInform Abstract: Copper(I) Oxide and Benzoic Acid “On Water”: A Highly Practical and Efficient Catalytic System for Copper(I)‐Catalyzed Azide—Alkyne Cycloaddition.
Authors: Shao Changwei , Zhu Rui , Luo Sheng , Zhang Qun , Wang Xinyan , Hu Yuefei 
Published: September 2011

AbstractPre‐prepared copper(I) carboxylates are not necessary for the process, since they can be replaced by a combination of cheap, stable Cu2O and carboxylic acid.
ChemInform Abstract: Effect of Temperature on Triazole and Bistriazole Formation Through Copper‐Catalyzed Alkyne—Azide Cycloaddition.
Authors: Gonzalez Jaime , Perez Victor M. , Jimenez David O. , Lopez‐Valdez German , Corona David , Cuevas‐Yanez Erick 
Published: September 2011

AbstractThe reaction gives the expected triazoles in the presence of catalytic amounts of NaOH.
ChemInform Abstract: Synthesis of Hexahydro[2]benzopyrano[3,4‐c]pyrroles as Serotonin 5‐HT2C Receptor Agonists via Intramolecular Hetero Diels—Alder Reactions.
Authors: Kiyoi Takao , et al. et al. 
Published: September 2011

AbstractIntermolecular hetero‐Diels—Alder reaction of the dienes derived by electrocyclic ring‐opening of the benzocyclobutanes (I) gives diastereomeric mixtures of benzopyranopyrroles of type (II) and (III).
ChemInform Abstract: Synthesis of Hexahydro[2]benzopyrano[4,3‐c]pyridines as Serotonin 5‐HT2C Receptor Agonists via Intramolecular Hetero Diels—Alder Reactions.
Authors: Kiyoi Yasuko , Laats Steven , Kiyoi Takao , Wishart Grant , Brown Angus , Ray Peter 
Published: September 2011

AbstractThe title skeleton (II)/(III) is prepared in analogy to the pyrrole systems in the preceding paper.
ChemInform Abstract: Facile Synthesis of 4‐Acetyl‐coumarins, ‐thiocoumarins and ‐quinolin‐2(1H)‐one via Very High α‐Regioselective Heck Coupling on Tosylates.
Authors: Valente Sergio , Kirsch Gilbert 
Published: September 2011

AbstractThe interesting approach includes Pd‐catalyzed Heck coupling of the tosylates with ether (II) followed by acidic rearrangement of the resulting vinyl ether intermediate.
ChemInform Abstract: Orally Active Aminopyridines as Inhibitors of Tetrameric Fructose‐1,6‐bisphosphatase.
Authors: Kitas Eric , et al. et al. 
Published: September 2011

AbstractAminopyridines exhibiting high aqueous solubility, PAMPA permeability, and good efficacy in primary hepatocytes are synthesized by using a general and straightforward approach.
ChemInform Abstract: Enamines in Heterocyclic Synthesis: A Novel Simple and Efficient Route to Condensed Pyridazines.
Authors: Darwish Elham S. , Abdelrahman Mahmoud A. , Salaheldin Abdellatif M. 
Published: September 2011

AbstractIn situ generated 1‐(diethoxymethyl)piperidine is shown to be a useful reagent to replace the expensive, highly volatile and toxic N,N‐dimethylformamide dimethyl acetal for converting active methylene compounds into enamines.
ChemInform Abstract: Xanthones in Heterocyclic Synthesis. An Efficient and General Route for the Synthesis of Regioselectively Substituted Phthalazines.
Authors: Gardikis Yiannis , Tsoungas Petros G. , Potamitis Constantinos , Pairas George , Zervou Maria , Cordopatis Paul 
Published: September 2011

AbstractDiaryl diketones such as (I) derived from substituted xanthenes can easily be converted to the corresponding phthalazines on treatment with hydrazine.
ChemInform Abstract: Reactions of 3,6‐Bis(3,5‐dimethyl‐4‐R‐pyrazol‐1‐yl)‐1,2,4,5‐tetrazines with Indole and 1,3,3‐Trimethyl‐2‐methyleneindoline.
Authors: Ishmetova Rashida I. , Ignatenko Nina K. , Ganebnykh Ilya N. , Tolshchina Svetlana G. , Slepukhin Pavel A. , Rusinov Gennady L. 
Published: September 2011

AbstractTetrazine derivatives (I) undergo a [4 + 2]‐cycloaddition with indole (II) and methylene indoline (IV) to give pyridazine derivatives (III) and (V), respectively.
ChemInform Abstract: Synthesis and Biological Evaluation of Conformationally Flexible as well as Restricted Dimers of Monastrol and Related Dihydropyrimidones.
Authors: Kamal Ahmed , Malik M. Shaheer , Bajee Shaik , Azeeza Shaik , Faazil Shaikh , Ramakrishna Sistla , Naidu V. G. M. , Vishnuwardhan M. V. P. S. 
Published: September 2011

AbstractThe one‐pot Biginelli multi‐component cyclocondensation reaction affords dimers of monastrol and related dihydropyrimidones with flexible alkyl chain spacers of varying length and conformationally restricted spacers with unsaturation.
ChemInform Abstract: Rhodium‐Catalyzed Cycloisomerization Involving Cyclopropenes: Efficient Stereoselective Synthesis of Medium‐Sized Heterocyclic Scaffolds.
Authors: Miege Frederic , Meyer Christophe , Cossy Janine 
Published: September 2011

AbstractThe methodology provides access to functionalized carbocyclic or heterocyclic scaffolds fused to an aromatic ring.
ChemInform Abstract: Phosphonate‐Free Phosphorylation of Alcohols Using Bis‐(tert‐butyl) Phosphoramidite with Imidazole Hydrochloride and Imidazole as the Activator.
Authors: Hache Bruno , Brett Lisa , Shakya Sagar 
Published: September 2011

AbstractUnder the improved conditions, formation of undesired phosphonate by‐products is suppressed.
ChemInform Abstract: New Red Pigments from Lichen Lethariella sinensis
Authors: Tanaka Ayako , Kinoshita Kaoru , Ichinose Koji , Togawa Tadayasu , Koyama Kiyotaka , Narui Takao , Wang Li‐song , Takahashi Kunio 
Published: September 2011

Abstractisolation and structural elucidation of rubrosinensiquinones A (I), B (II) and C (III)
ChemInform Abstract: Simultaneously Rapid Deprotection of 3‐Acyloxy Groups and Reduction of D‐Ring Ketones (Nitriles) of Steroids Using DIBAL‐H/NiCl2.
Authors: Wang Xingbin , Liu Hui , Yan Peiyun , Liu Jinliang , Li Yan , Sun Qian , Wang Cunde 
Published: September 2011

AbstractVarious hydroxysteroids are efficiently obtained in a rapid one‐pot reaction under mild reaction conditions.
ChemInform Abstract: Synthesis of (25R)‐17α‐Hydroxy‐22‐oxocholest‐5‐ene‐3β,16β,26‐triyl Triacetate: A One‐Pot Approach to the Protected Aglycon Analogue of OSW‐1.
Authors: Fernandez‐Herrera Maria A. , Hernandez‐Linares Ma. G. , Guerrero‐Luna Gabriel , Meza‐Reyes Socorro , Montiel‐Smith Sara , Sandoval‐Ramirez Jesus 
Published: September 2011

AbstractThe spirostanic side chain of pennogenin (I) can be quantitatively transformed under mild acidic conditions in a 22‐oxocholestanic framework through a one‐step procedure.
ChemInform Abstract: Dye‐Sensitized Photooxygenation of 2,5‐Bis(glycosyl)furans.
Authors: Cermola Flavio , Iesce Maria R. , Astarita Anna , Passananti Monica 
Published: September 2011

AbstractThe dye‐sensitized photooxygenation of the title compounds followed by warming to room temperature provides 1,1′‐linked disaccharides separated by a functionalized spacer.
ChemInform Abstract: Purinium Derivatives with Antitumor Activities from Heterostemma alatum Wight.
Authors: Fu Wen‐Wei , Tan Chang‐Heng , Zhuang Peng‐Yu , Yang Shu‐Min , Luo Hong‐Feng , Tan Jun‐Jie , Liu Ping , Zhu Da‐Yuan 
Published: September 2011

Abstractisolation, structure elucidation and cytotoxic activity of a new purinium derivative, heteromine I (I), along with six known compounds
ChemInform Abstract: Antiinflammatory Activity of Constituents from Glechoma hederacea var. longituba.
Authors: Kim Jin‐Pyo , Song Seok‐Bean , Lee Ik‐Soo , Kim Young‐Ho , Yoo Ick‐Dong , Ryoo In‐Ja , Bae Ki‐Hwan 
Published: September 2011

AbstractRosmarinic acid, its analogues, and a phenolic compound are isolated from the title plant, including two new compounds (I) and (II) and four known compounds.
ChemInform Abstract: Amino‐, Alkoxy‐, and Alkylthio‐isocyanates and ‐isothiocyanates, RX—NCY, Their Isomers RX—YCN and RX—CNY, and Their Rearrangements
Authors: Wentrup Curt , Finnerty Justin J. , Koch Rainer 
Published: September 2011

AbstractReview: 133 refs.
ChemInform Abstract: Flexible Fabrication and Applications of Polymer Nanochannels and Nonoslits
Authors: Chantiwas Rattikan , Park Sunggook , Soper Steven A. , Kim Byoung Choul , Takayama Shuichi , Sunkara Vijaya , Hwang Hyundoo , Cho Yoon‐Kyoung 
Published: September 2011

AbstractReview: 257 refs.
Complementary colors theory of color vision: Physiology, color mixture, color constancy and color perception
Authors: Pridmore Ralph W. 
Published: September 2011

AbstractI describe complementary colors' physiology and functional roles in color vision, in a three‐stage theory (receptor, opponent color, and complementary color stages). 40 specific roles include the complementary structuring of: S and L cones, opponent single cells, cardinal directions, hue cycle structure, hue constancy, trichromatic color mixture, additive/subtractive primaries, two unique hues, color mixture space, uniform hue difference, lightness‐, saturation‐, and wavelength/hue‐discrimination, spectral sensitivity, chromatic adaptation, metamerism, chromatic induction, Helson‐Judd effect, colored shadows, color rendering, warm‐cool colors, brilliance, color harmony, Aristotle's flight of colors, white‐black responsivity, Helmholtz‐Kohlrausch effect, rainbows/halos/glories, dichromatism, spectral‐sharpening, and trimodality of functions (RGB peaks, CMY troughs whose complementarism adapts functions to illuminant). The 40 specific roles fall into 3 general roles: color mixture, color constancy, and color perception. Complementarism evidently structures much of the visual process. Its physiology is evident in complementarism of cones, and opponent single cells in retina, LGN, and cortex. Genetics show our first cones were S and L, which are complementary in daylight D65, giving a standard white to aid chromatic adaptation. M cone later split from L to oppose the nonspectral (red and purple) hues mixed from S+L. Response curves and wavelength peaks of cones L, S, and (S+L), M, closely resemble, and lead to, those of opponent‐color chromatic responses y, b, and r, g, a bimodal system whose summation gives spectral‐sharpened trimodal complementarism (RGB peaks, CMY troughs). Spectral sharpening demands a post‐receptoral, post‐opponent‐colors location, hence a third stage. © 2011 Wiley Periodicals, Inc. Col Res Appl, 2011
Reduction Potentials and Acidity Constants of Mn Superoxide Dismutase Calculated by QM/MM Free‐Energy Methods
Authors: Heimdal Jimmy , Kaukonen Markus , Srnec Martin , Rulíšek Lubomír , Ryde Ulf 
Published: September 2011

AbstractWe used two theoretical methods to estimate reduction potentials and acidity constants in Mn superoxide dismutase (MnSOD), namely combined quantum mechanical and molecular mechanics (QM/MM) thermodynamic cycle perturbation (QTCP) and the QM/MM‐PBSA approach. In the latter, QM/MM energies are combined with continuum solvation energies calculated by solving the Poisson–Boltzmann equation (PB) or by the generalised Born approach (GB) and non‐polar solvation energies calculated from the solvent‐exposed surface area. We show that using the QTCP method, we can obtain accurate and precise estimates of the proton‐coupled reduction potential for MnSOD, 0.30±0.01 V, which compares favourably with experimental estimates of 0.26–0.40 V. However, the calculated potentials depend strongly on the DFT functional used: The B3LYP functional gives 0.6 V more positive potentials than the PBE functional. The QM/MM‐PBSA approach leads to somewhat too high reduction potentials for the coupled reaction and the results depend on the solvation model used. For reactions involving a change in the net charge of the metal site, the corresponding results differ by up to 1.3 V or 24 pKa units, rendering the QM/MM‐PBSA method useless to determine absolute potentials. However, it may still be useful to estimate relative shifts, although the QTCP method is expected to be more accurate.
Is Universal, Simple Melting Point Prediction Possible?
Authors: Preiss Ulrich P. , Beichel Witali , Erle Anna M. T. , Paulechka Yauheni U. , Krossing Ingo 
Published: September 2011

AbstractAn investigation of the melting points of 520 organic 1:1 salts is presented with the aim of developing a universal, simple, physically well‐founded prediction scheme. The general reliability and reproducibility of the recorded experimental data are discussed with respect to purity, phase behavior, disorder and thermal history of a given substance. Additionally, mistakes, systematic errors, or lack of conventions can lead to considerable differences in the experimental measurements. A rough error bar for the reproducibility of the melting points of organic salts of ±5 to ±15 °C can be assigned. With this restraint, we developed two simple, semiempirical, five‐ and nine‐parameter schemes with easy‐to‐calculate quantities. With these, we could predict the melting temperature of a given organic salt in the temperature range of −25 to +300 °C with an average error of 33.5 °C and a relative error of 9.3 %. All calculated quantities are assessed with the help of conventional DFT, COSMO and COSMO‐RS calculations, and are currently implemented into the IL‐Prop module of the upcoming version of COSMOtherm. These prediction schemes are suitable for high‐throughput computational screening of substances in the context of “computer‐aided synthesis”. Therefore, they are valuable tools to find a compound with a suitable melting point before its first synthesis.
Atypical development of resting respiratory sinus arrhythmia in children at high risk for depression
Authors: Gentzler Amy L. , Rottenberg Jonathan , Kovacs Maria , George Charles J. , Morey Jennifer N. 
Published: September 2011

AbstractCompromised respiratory sinus arrhythmia (RSA, i.e., low cardiac vagal control) frequently characterizes clinically depressed adults and also has been detected in infants of depressed mothers; however, its existence has not been established in older at‐risk offspring. We investigated developmental patterns of RSA in a sample of 163 5‐ to 14‐year‐old children, who were either at high risk for depression (due to having a parent with a childhood‐onset mood disorder) or low‐risk for depression. We hypothesized that high‐risk children have lower resting RSA than do low‐risk children, which could reflect atypical developmental trajectories. Children's RSA was assessed during resting baseline periods on multiple occasions, typically 1‐year apart. Linear growth modeling indicated a group by age interaction. Low‐risk children (but not the high‐risk children) exhibited a significantly increasing trajectory in resting RSA with age. Mood disorders in offspring did not account for the Group X Age interaction effect. Our study provides new evidence that children at high risk for depression have an atypical developmental trajectory of RSA across late childhood. © 2011 Wiley Periodicals,Inc. Dev Psychobiol 54: 556–567, 2012.
Comparison of embryonic expression within multigene families using the flyexpress discovery platform reveals more spatial than temporal divergence
Authors: Konikoff Charlotte E. , Karr Timothy L. , McCutchan Michael , Newfeld Stuart J. , Kumar Sudhir 
Published: September 2011

AbstractBackground: Overlaps in spatial patterns of gene expression are frequently an initial clue to genetic interactions during embryonic development. However, manual inspection of images requires considerable time and resources impeding the discovery of important interactions because tens of thousands of images exist. The FlyExpress discovery platform was developed to facilitate data‐driven comparative analysis of expression pattern images from Drosophila embryos. Results: An image‐based search of the BDGP and Fly‐FISH datasets conducted in FlyExpress yields fewer but more precise results than text‐based searching when the specific goal is to find genes with overlapping expression patterns. We also provide an example of a FlyExpress contribution to scientific discovery: an analysis of gene expression patterns for multigene family members revealed that spatial divergence is far more frequent than temporal divergence, especially after the maternal to zygotic transition. This discovery provides a new clue to molecular mechanisms whereby duplicated genes acquire novel functions. Conclusions: The application of FlyExpress to understanding the process by which new genes acquire novel functions is just one of a myriad of ways in which it can contribute to our understanding of developmental and evolutionary biology. This resource has many other potential applications, limited only by the investigator's imagination. Developmental Dynamics 241:150–160, 2012. © 2011 Wiley Periodicals, Inc.
Axial protocadherin (AXPC) regulates cell fate during notochordal morphogenesis
Authors: Yoder Michael D. , Gumbiner Barry M. 
Published: September 2011

AbstractThe separation and specification of mesoderm into the notochord and somites involves members of the non‐clustered δ‐protocadherins. Axial (AXPC) and paraxial (PAPC) protocadherins are expressed in the early dorsal mesoderm and later become refined to the developing notochordal and somitic mesoderm, respectively. The role of PAPC in this process has been studied extensively, but the role of AXPC is poorly understood. Partial knockdown of AXPC causes a specific bent‐axis phenotype, while more severe knockdown results in the loss of notochord formation. The inability of these embryos to develop a notochord is not due to a cell‐sorting event via changes in cell adhesion during gastrulation, but rather this defect is manifested through the loss of axial mesoderm specification, but not general mesoderm induction. The results presented here show that AXPC functions in notochord morphogenesis by directing cell‐fate decisions rather than cell‐cell adhesion. Developmental Dynamics 240:2495–2504, 2011. © 2011 Wiley Periodicals, Inc.
A fine‐grained analysis of eating behavior in women with bulimia nervosa
Authors: Mitchell James E. , Karr Trisha M. , Peat Christina , Wonderlich Stephen , Crosby Ross D. , Engel Scott , Simonich Heather 
Published: September 2011

AbstractObjective:In the current study, we were interested in developing a typology of eating in patients with bulimia nervosa (BN) based on the size of the eating episode, whether the episode was followed by self‐induced vomiting, and the degree of loss of control (LOC) self‐reported by participants.Method:Twenty‐one women with BN, purging type, were evaluated using the Nutritional Data System for Research, the Eating Disorders Examination, and the Matrix.Results:The most common type of episode resembled what might be termed “normal” eating, which involved the consumption of <1,000 kcal with no sense of LOC and no vomiting. There was an increase in severity of self‐assessed LOC in objectively large eating episodes with vomiting. Self‐reported hunger prior to eating episodes did not seem to be predictive of subsequent behavior. Most people were engaged in other behaviors while eating.Discussion:The results of this study suggest a typology that included primarily four types of eating episodes. The results also suggest that when LOC is assessed on a Likert‐scale rather than as a dichotomous variable, there is considerable variability in self‐assessed degree of LOC. © 2011 by Wiley Periodicals, Inc. (Int J Eat Disord 2012)
Cooperative Catalysis with First‐Row Late Transition Metals
Authors: van der Vlugt Jarl Ivar 
Published: September 2011

AbstractCooperative catalysis with first‐row transition metals holds much promise for future developments regarding sustainable, selective transformations, including e.g. alkenes, dienes and a variety of small molecules such as CO2, N2 and water. This non‐exhaustive analysis of the current state‐of‐the‐art aims to give a comprehensive overview of the various design strategies and applications of first‐row transition metal cooperative reactivity and to provide leads for new research initiatives in order to expand this emerging field. The main aspects covered involve bimetallic cooperativity, redox‐noninnocent ligands in combination with first‐row transition metal complexes, otherwise reactive or noninnocent scaffolds that can induce metal‐ligand bifunctional substrate activation and the design of adaptive ligands and complexes thereof, wherein hemilability is a key factor for selective reactivity. The metals under review are primarily the late transition metals Fe, Co, Ni and Cu.
Selective and Rapid Room Temperature Detection of H2S Using Gold Nanoparticle Chain Arrays
Authors: Lee Joun , Mubeen Syed , Hangarter Carlos M. , Mulchandani Ashok , Chen Wilfred , Myung Nosang V. 
Published: September 2011

AbstractA novel conductometric hydrogen sulfide (H2S) sensor was fabricated by AC dielectrophoretic assembly of amino acid mediated grown gold nanoparticles across microfabricated gold electrodes. Excellent sensing performance toward hydrogen sulfide, including a sensitivity of 29.84 % ppm−1, a lower detection limit in the sub‐ppm level, the upper detection limit of 2 ppm, and a response time of<20 s for 10 ppm H2S was achieved at room temperature. In addition, excellent selectivity was demonstrated toward CO and SO2 with minimum interference from NH3. Enhanced sensor performance may be attributed to the use of amino acid capped gold nanoparticles compared to thiolated gold nanoparticles and optimized assembly conditions to control the density of gold nanoparticle chains and electron transport properties.
Relationship between symptoms of depression and agitation in nursing home residents with dementia
Authors: Volicer Ladislav , Frijters Dinnus H.M. , Van der Steen Jenny T. 
Published: September 2011

ObjectiveThe aim of this study is to analyze modifiable factors related to agitation of nursing home residents with dementia.MethodsRelationship of agitation with three modifiable factors (depression, psychosis, and pain) was explored using longitudinal Minimum Data Set (MDS) information from 2032 residents of Dutch nursing homes. Presence of agitation and depression was ascertained using validated scales based on MDS information. Presence of psychosis and pain was ascertained from the individual MDS items.ResultsThere was a significant correlation between MDS depression and agitation scores. Depression scores increased in residents whose agitation worsened and decreased in residents whose agitation improved. Psychosis scores (combination of delusions and hallucinations) also correlated with MDS depression scores, and psychosis scores increased in residents whose agitation worsened. Pain scores correlated with agitation scores, but the pain scores did not change with changes in agitation. Depression symptoms were present in 51% of residents, while psychotic symptoms were present only in 15% of residents, and two‐thirds of these residents were also depressed.ConclusionThese results indicate that depression may be the most common factor associated with agitation in nursing home residents with dementia. Copyright © 2011 John Wiley & Sons, Ltd.