bluuebunny/crossref_metadata_2025_split huggingface dataset:
Perceived Treatment Assignment and Smoking Cessation in a Clinical Trial of Bupropion
Authors: Buchanan TS , Cox LS , Nollen NL , Thomas JL , Berg CJ , Mayo MS , Ahluwalia JS 
Published: March 2011

Abstract
Research on tobacco cessation pharmacotherapy often relies on double-blind, placebo-controlled randomized trials. These studies are designed to control for the placebo effect (i.e., the influence of participants' expectations on treatment outcome). Psychoactive effects of smoking cessation medications such as bupropion may allow participants to correctly guess their treatment assignment at rates greater than chance. Perceived treatment assignment could potentially impact smoking cessation rates. The aim of this study was to determine the impact of perceived treatment assignment on end-of-treatment cotinine-verified smoking abstinence among African-American light smokers [≤10 cigarettes per day (cpd)] enrolled in a double-blind, placebo-controlled study of bupropion. Participants were randomized to bupropion (150 mg bid) or placebo and received identical written materials and health education counseling. Participants (n = 390) included in this study reported their perceived treatment assignment on the end-of-treatment (week 7) survey. They were predominantly female (63.1%), 48.1 years (SD = 11.2), and smoked 8 cpd (SD = 2.5). The majority (81.3%) smoked menthol cigarettes. Participants given bupropion were more likely to correctly guess their treatment assignment (69%; 140/203) than those assigned to placebo (51.3%; 96/187). Quit rates by treatment assignment were 31.5% (bupropion) versus 13.9% (placebo) (OR = 2.78, 95% CI 1.61–5.43, P &lt; 0.01). After adjusting for treatment, participants who perceived assignment to bupropion versus placebo were not more likely to be abstinent (OR = 1.37; 95% CI 0.71–2.64, P = 0.35).The interaction between treatment and perceived treatment assignment was also nonsignificant. Consistent with two previous studies with bupropion, there was evidence of blinding failure for the treatment group. However, in our study, perceived treatment assignment did not significantly impact cotinine-verified cessation outcome at end-of-treatment (week 7). These findings suggest that the role of perceived treatment assignment on smoking cessation with bupropion may differ for light smokers compared to heavier smokers (&gt;10 cpd) sampled in the two earlier studies. Current findings might indicate that expectations of pharmacotherapy are less salient for light smokers.
Mucin 13: Structure, Function, and Potential Roles in Cancer Pathogenesis
Authors: Maher Diane M. , Gupta Brij K. , Nagata Satoshi , Jaggi Meena , Chauhan Subhash C. 
Published: March 2011

Abstract
Mucin 13 (MUC13) is a high-molecular-weight transmembrane glycoprotein that is frequently and aberrantly expressed in a variety of epithelial carcinomas, including gastric, colorectal, and ovarian cancers. On the basis of the high expression of MUC13 in cancer cells as well as recent laboratory findings suggesting a malignant phenotype of MUC13-transfected cell lines, the oncogenic potential of MUC13 has emerged. The various functional domains of MUC13 may confer oncogenic potential to MUC13. For example, the bulky extracellular domain with extensive modification with glycan chains may prevent cell–cell and cell–extracellular matrix binding whereas the cytoplasmic tail containing serine and tyrosine residues for potential phosphorylation may participate in cell signaling. MUC13 exhibits the characteristics suitable as an early marker for cancer screening and presents a promising target for antibody-guided targeted therapy. Mol Cancer Res; 9(5); 531–7. ©2011 AACR.
Uncoupling p53 Functions in Radiation-Induced Intestinal Damage via PUMA and p21
Authors: Leibowitz Brian J. , Qiu Wei , Liu Hongtao , Cheng Tao , Zhang Lin , Yu Jian 
Published: March 2011

Abstract
The role of p53 in tissue protection is not well understood. Loss of p53 blocks apoptosis in the intestinal crypts following irradiation but paradoxically accelerates gastrointestinal (GI) damage and death. PUMA and p21 are the major mediators of p53-dependent apoptosis and cell-cycle checkpoints, respectively. To better understand these two arms of p53 response in radiation-induced GI damage, we compared animal survival, as well as apoptosis, proliferation, cell-cycle progression, DNA damage, and regeneration in the crypts of WT, p53 knockout (KO), PUMA KO, p21 KO, and p21/PUMA double KO (DKO) mice in a whole body irradiation model. Deficiency in p53 or p21 led to shortened survival but accelerated crypt regeneration associated with massive nonapoptotic cell death. Nonapoptotic cell death is characterized by aberrant cell-cycle progression, persistent DNA damage, rampant replication stress, and genome instability. PUMA deficiency alone enhanced survival and crypt regeneration by blocking apoptosis but failed to rescue delayed nonapoptotic crypt death or shortened survival in p21 KO mice. These studies help to better understand p53 functions in tissue injury and regeneration and to potentially improve strategies to protect or mitigate intestinal damage induced by radiation. Mol Cancer Res; 9(5); 616–25. ©2011 AACR.
Implicit and Explicit Mechanisms of Word Learning in a Narrative Context: An Event-related Potential Study
Authors: Batterink Laura , Neville Helen 
Published: March 2011

AbstractThe vast majority of word meanings are learned simply by extracting them from context rather than by rote memorization or explicit instruction. Although this skill is remarkable, little is known about the brain mechanisms involved. In the present study, ERPs were recorded as participants read stories in which pseudowords were presented multiple times, embedded in consistent, meaningful contexts (referred to as meaning condition, M+) or inconsistent, meaningless contexts (M−). Word learning was then assessed implicitly using a lexical decision task and explicitly through recall and recognition tasks. Overall, during story reading, M− words elicited a larger N400 than M+ words, suggesting that participants were better able to semantically integrate M+ words than M− words throughout the story. In addition, M+ words whose meanings were subsequently correctly recognized and recalled elicited a more positive ERP in a later time window compared with M+ words whose meanings were incorrectly remembered, consistent with the idea that the late positive component is an index of encoding processes. In the lexical decision task, no behavioral or electrophysiological evidence for implicit priming was found for M+ words. In contrast, during the explicit recognition task, M+ words showed a robust N400 effect. The N400 effect was dependent upon recognition performance, such that only correctly recognized M+ words elicited an N400. This pattern of results provides evidence that the explicit representations of word meanings can develop rapidly, whereas implicit representations may require more extensive exposure or more time to emerge.
Seeing Race: N170 Responses to Race and Their Relation to Automatic Racial Attitudes and Controlled Processing
Authors: Ofan Renana H. , Rubin Nava , Amodio David M. 
Published: March 2011

Abstract
We examined the relation between neural activity reflecting early face perception processes and automatic and controlled responses to race. Participants completed a sequential evaluative priming task, in which two-tone images of Black faces, White faces, and cars appeared as primes, followed by target words categorized as pleasant or unpleasant, while encephalography was recorded. Half of these participants were alerted that the task assessed racial prejudice and could reveal their personal bias (“alerted” condition). To assess face perception processes, the N170 component of the ERP was examined. For all participants, stronger automatic pro-White bias was associated with larger N170 amplitudes to Black than White faces. For participants in the alerted condition only, larger N170 amplitudes to Black versus White faces were also associated with less controlled processing on the word categorization task. These findings suggest that preexisting racial attitudes affect early face processing and that situational factors moderate the link between early face processing and behavior.
Inflexibly Focused under Stress: Acute Psychosocial Stress Increases Shielding of Action Goals at the Expense of Reduced Cognitive Flexibility with Increasing Time Lag to the Stressor
Authors: Plessow Franziska , Fischer Rico , Kirschbaum Clemens , Goschke Thomas 
Published: March 2011

Abstract
Dynamically adjusting the right amount of goal shielding to varying situational demands is associated with the flexibility of cognitive control, typically linked with pFC functioning. Although stress hormones are found to also bind to prefrontal receptors, the link between stress and cognitive control remains elusive. Based on that, we aimed at investigating effects of acute psychosocial stress on dynamic control adjustments. Forty-eight healthy volunteers were exposed to either a well-established stress induction protocol (the Trier Social Stress Test, TSST) or a standardized control situation before a selective attention (Simon) task involving response conflicts. The individual physiological stress response was monitored by analyzing levels of free cortisol and α-amylase activity in saliva samples showing that the TSST reliably induced an increase of endogenous stress hormone levels. Acute stress did not inevitably impair cognitive functioning, however, as stressed participants showed tonically increased goal shielding (to reduce interference) at the expense of decreased cognitive flexibility. Importantly, as a novel finding in humans, stress effects on cognitive functions were not present immediately after the stress experience but developed gradually over time and, therefore, paralleled the time course of the hypothalamus–pituitary–adrenal (HPA) stress response. In addition, the total increase of individual cortisol levels reflecting HPA activity, but not the total changes in α-amylase activity associated with sympathetic activity, was reversely related to the amount of cognitive flexibility in the final block of testing. Our study provides evidence for a stress-induced time-dependent decrease of cognitive flexibility that might be related to changes in cortisol levels.
Theta and Gamma Power Increases and Alpha/Beta Power Decreases with Memory Load in an Attractor Network Model
Authors: Lundqvist Mikael , Herman Pawel , Lansner Anders 
Published: March 2011

Abstract
Changes in oscillatory brain activity are strongly correlated with performance in cognitive tasks and modulations in specific frequency bands are associated with working memory tasks. Mesoscale network models allow the study of oscillations as an emergent feature of neuronal activity. Here we extend a previously developed attractor network model, shown to faithfully reproduce single-cell activity during retention and memory recall, with synaptic augmentation. This enables the network to function as a multi-item working memory by cyclic reactivation of up to six items. The reactivation happens at theta frequency, consistently with recent experimental findings, with increasing theta power for each additional item loaded in the network's memory. Furthermore, each memory reactivation is associated with gamma oscillations. Thus, single-cell spike trains as well as gamma oscillations in local groups are nested in the theta cycle. The network also exhibits an idling rhythm in the alpha/beta band associated with a noncoding global attractor. Put together, the resulting effect is increasing theta and gamma power and decreasing alpha/beta power with growing working memory load, rendering the network mechanisms involved a plausible explanation for this often reported behavior.
Orienting Attention in Time Activates Left Intraparietal Sulcus for Both Perceptual and Motor Task Goals
Authors: Davranche Karen , Nazarian Bruno , Vidal Franck , Coull Jennifer 
Published: March 2011

Abstract
Attention can be directed not only toward a location in space but also to a moment in time (“temporal orienting”). Temporally informative cues allow subjects to predict when an imminent event will occur, thereby speeding responses to that event. In contrast to spatial orienting, temporal orienting preferentially activates left inferior parietal cortex. Yet, left parietal cortex is also implicated in selective motor attention, suggesting its activation during temporal orienting could merely reflect incidental engagement of preparatory motor processes. Using fMRI, we therefore examined whether temporal orienting would still activate left parietal cortex when the cued target required a difficult perceptual discrimination rather than a speeded motor response. Behaviorally, temporal orienting improved accuracy of target identification as well as speed of target detection, demonstrating the general utility of temporal cues. Crucially, temporal orienting selectively activated left inferior parietal cortex for both motor and perceptual versions of the task. Moreover, conjunction analysis formally revealed a region deep in left intraparietal sulcus (IPS) as common to both tasks, thereby identifying it as a core neural substrate for temporal orienting. Despite the context-independent nature of left IPS activation, complementary psychophysiological interaction analysis revealed how the functional connectivity of left IPS changed as a function of task context. Specifically, left IPS activity covaried with premotor activity during motor temporal orienting but with visual extrastriate activity during perceptual temporal orienting, thereby revealing a cooperative network that comprises both temporal orienting and task-specific processing nodes.
Inhibition-related Activation in the Right Inferior Frontal Gyrus in the Absence of Inhibitory Cues
Authors: Lenartowicz Agatha , Verbruggen Frederick , Logan Gordon D. , Poldrack Russell A. 
Published: March 2011

Abstract
The right inferior frontal gyrus (rIFG) has been hypothesized to mediate response inhibition. Typically response inhibition is signaled by an external stop cue, which provides a top–down signal to initiate the process. However, recent behavioral findings suggest that response inhibition can also be triggered automatically by bottom–up processes. In the present study, we evaluated whether rIFG activity would also be observed during automatic inhibition, in which no stop cue was presented and no motor inhibition was actually required. We measured rIFG activation in response to stimuli that were previously associated with stop signals but which required a response on the current trial (reversal trials). The results revealed an increase in rIFG (pars triangularis) activity, suggesting that it can be activated by associations between stimuli and stopping. Moreover, its role in inhibition tasks is not contingent on the presence of an external stop cue. We conclude that rIFG involvement in stopping is consistent with a role in reprogramming of action plans, which may comprise inhibition, and its activity can be triggered through automatic, bottom–up processing.
Comparison of Primate Prefrontal and Premotor Cortex Neuronal Activity during Visual Categorization
Authors: Cromer Jason A. , Roy Jefferson E. , Buschman Timothy J. , Miller Earl K. 
Published: March 2011

Abstract
Previous work has shown that neurons in the PFC show selectivity for learned categorical groupings. In contrast, brain regions lower in the visual hierarchy, such as inferior temporal cortex, do not seem to favor category information over information about physical appearance. However, the role of premotor cortex (PMC) in categorization has not been studied, despite evidence that PMC is strongly engaged by well-learned tasks and reflects learned rules. Here, we directly compare PFC neurons with PMC neurons during visual categorization. Unlike PFC neurons, relatively few PMC neurons distinguished between categories of visual images during a delayed match-to-category task. However, despite the lack of category information in the PMC, more than half of the neurons in both PFC and PMC reflected whether the category of a test image did or did not match the category of a sample image (i.e., had match information). Thus, PFC neurons represented all variables required to solve the cognitive problem, whereas PMC neurons instead represented only the final decision variable that drove the appropriate motor action required to obtain a reward. This dichotomy fits well with PFC's hypothesized role in learning arbitrary information and directing behavior as well as the PMC's role in motor planning.
Axisymmetric Hurricane in a Dry Atmosphere: Theoretical Framework and Numerical Experiments
Authors: Mrowiec Agnieszka A. , Garner Stephen T. , Pauluis Olivier M. 
Published: March 2011

Abstract
This paper discusses the possible existence of hurricanes in an atmosphere without water vapor and analyzes the dynamic and thermodynamic structures of simulated hurricane-like storms in moist and dry environments. It is first shown that the “potential intensity” theory for axisymmetric hurricanes is directly applicable to the maintenance of a balanced vortex sustained by a combination of surface energy and momentum flux, even in the absence of water vapor. This theoretical insight is confirmed by simulations with a high-resolution numerical model. The same model is then used to compare dry and moist hurricanes. While it is found that both types of storms exhibit many similarities and fit well within the theoretical framework, there are several differences, most notably in the storm inflow and in the relationship between hurricane size and intensity. Such differences indicate that while water vapor is not necessary for the maintenance of hurricane-like vortices, moist processes directly affect the structure of these storms.
Vertical Structures of Anvil Clouds of Tropical Mesoscale Convective Systems Observed by CloudSat
Authors: Yuan Jian , Houze Robert A. , Heymsfield Andrew J. 
Published: March 2011

Abstract
A global study of the vertical structures of the clouds of tropical mesoscale convective systems (MCSs) has been carried out with data from the CloudSat Cloud Profiling Radar. Tropical MCSs are found to be dominated by cloud-top heights greater than 10 km. Secondary cloud layers sometimes occur in MCSs, but outside their primary raining cores. The secondary layers have tops at 6–8 and 1–3 km. High-topped clouds extend outward from raining cores of MCSs to form anvil clouds. Closest to the raining cores, the anvils tend to have broader distributions of reflectivity at all levels, with the modal values at higher reflectivity in their lower levels. Portions of anvil clouds far away from the raining core are thin and have narrow frequency distributions of reflectivity at all levels with overall weaker values. This difference likely reflects ice particle fallout and therefore cloud age. Reflectivity histograms of MCS anvil clouds vary little across the tropics, except that (i) in continental MCS anvils, broader distributions of reflectivity occur at the uppermost levels in the portions closest to active raining areas; (ii) the frequency of occurrence of stronger reflectivity in the upper part of anvils decreases faster with increasing distance in continental MCSs; and (iii) narrower-peaked ridges are prominent in reflectivity histograms of thick anvil clouds close to the raining areas of connected MCSs (superclusters). These global results are consistent with observations at ground sites and aircraft data. They present a comprehensive test dataset for models aiming to simulate process-based upper-level cloud structure around the tropics.
On the Linkage between Antarctic Surface Water Stratification and Global Deep-Water Temperature
Authors: Keeling Ralph F. , Visbeck Martin 
Published: March 2011

Abstract
The suggestion is advanced that the remarkably low static stability of Antarctic surface waters may arise from a feedback loop involving global deep-water temperatures. If deep-water temperatures are too warm, this promotes Antarctic convection, thereby strengthening the inflow of Antarctic Bottom Water into the ocean interior and cooling the deep ocean. If deep waters are too cold, this promotes Antarctic stratification allowing the deep ocean to warm because of the input of North Atlantic Deep Water. A steady-state deep-water temperature is achieved such that the Antarctic surface can barely undergo convection. A two-box model is used to illustrate this feedback loop in its simplest expression and to develop basic concepts, such as the bounds on the operation of this loop. The model illustrates the possible dominating influence of Antarctic upwelling rate and Antarctic freshwater balance on global deep-water temperatures.
An Assessment of GCM Skill in Simulating Persistence across Multiple Time Scales
Authors: Johnson Fiona , Westra Seth , Sharma Ashish , Pitman Andrew J. 
Published: March 2011

Abstract
Climate change impact studies for water resource applications, such as the development of projections of reservoir yields or the assessment of likely frequency and amplitude of drought under a future climate, require that the year-to-year persistence in a range of hydrological variables such as catchment average rainfall be properly represented. This persistence is often attributable to low-frequency variability in the global sea surface temperature (SST) field and other large-scale climate variables through a complex sequence of teleconnections. To evaluate the capacity of general circulation models (GCMs) to accurately represent this low-frequency variability, a set of wavelet-based skill measures has been developed to compare GCM performance in representing interannual variability with the observed global SST data, as well as to assess the extent to which this variability is imparted in precipitation and surface pressure anomaly fields. A validation of the derived skill measures is performed using GCM precipitation as an input in a reservoir storage context, with the accuracy of reservoir storage estimates shown to be improved by using GCM outputs that correctly represent the observed low-frequency variability.
Significant differences in the performance of different GCMs is demonstrated, suggesting that judicious selection of models is required if the climate impact assessment is sensitive to low-frequency variability. The two GCMs that were found to exhibit the most appropriate representation of global low-frequency variability for individual variables assessed were the Istituto Nazionale di Geofisica e Vulcanologia (INGV) ECHAM4 and L’Institut Pierre-Simon Laplace Coupled Model, version 4 (IPSL CM4); when considering all three variables, the Max Planck Institute (MPI) ECHAM5 performed well. Importantly, models that represented interannual variability well for SST also performed well for the other two variables, while models that performed poorly for SST also had consistently low skill across the remaining variables.