bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Mouse Model of Damp-Heat Syndrome with Pancreatic Cancer in Traditional Chinese Medicine and Its Characteristics of Gut Microbiome
Authors: Tong Yangbo , Han Fang , Liu Mengyao , Xu Tianyu , Zhang Aiqin , Qin Jiangjiang , Zhang Yuhua , Qian Xiang 
Published: May 2024

Abstract

Introduction: Pancreatic cancer (PC) ranks seventh among cancer-related fatalities globally due to its dismal prognosis. The damp-heat syndrome is considered one of the most crucial syndromes associated with pancreatic cancer in Traditional Chinese Medicine (TCM). And there is growing evidence of research indicating that the gut microbiome co-evolves and changes during the course and development of PC. Nevertheless, there exist a noteworthy deficiency in comprehension in the modeling method and the characteristics of gut microbiome on model mice with damp-heat syndrome.
Methods: This study induced damp-heat syndrome with two methodologies and evaluated by survival rate, the appearance, activity status, abdominal fat, intestinal histology of the mice. Subsequently, PC cells were injected into mice with damp-heat syndrome to explore the effects of damp-heat syndrome on tumor growth. Statistical analysis was performed using SPSS. Additionally, intestinal bacteria were analyzed to further confirm the holistic impact of damp-heat syndrome on model mice using QIIME2. A p-value less than 0.05 was considered statistically significant.
Results: The modeling method combined with climate chamber and a diet high in sugar and fat was better with advantages of mice-friendly features, good stability and simple operation. This study verified that the promotion role of damp-heat syndrome on pancreatic cancer. Additionally, different intestinal flora markers were identified in the four subgroups: o_Lactobacillus in the control group, g_Treponema in the model group, g_Allobaculum in the CDHS group, and g_Coprobacillusin the CC group. Gammaproteobacteria at the order level and Enterobacteralesat the class level were significantly elevated in mice with damp-heat syndrome.
Discussion: This study established a damp-heat syndrome mouse model with pancreatic cancer successfully. Cancer-associated fibroblasts proliferation and alterations in intestinal flora contributed to the tumor-supportive effect of damp-heat syndrome on PC.
Numerical simulation of the agglomeration behaviour of spheroidal particles in homogeneous and isotropic turbulence
Authors: Anderson Jacob P. , Mortimer Lee F. , Hunter Timothy N. , Peakall Jeffrey , Fairweather Michael 
Published: May 2024

Abstract

Interactions between attractive spheroidal particle pairs are studied in boxes of homogeneous and isotropic turbulence. The fully resolved turbulence field and structure-resolved particle-fluid coupling regime are obtained through direct numerical simulation and an immersed boundary method. Agglomeration outcomes are accommodated through attractive van der Waals forces, suitably adapted to consider the orientational dependencies associated with the non-spherical shape. Binary particle interactions are first studied in quiescent conditions, as well as in a periodic box of homogeneous and isotropic turbulence. The latter is forced using a stochastic method, where the turbulence properties are chosen to approximate those observed in the viscous sublayer of a 180 shear Reynolds number channel flow. Differences in particle interaction behaviours are presented for the cases of disks and needles, with the role of orientation and kinetic energy in determining interaction outcomes analysed and contrasted with spheres. Results indicate that needles have the highest agglomeration propensity in turbulence, followed by spheres, and then disks. Lastly, the inclusion of attractive orientationally-dependent interaction forces promotes alignment between the symmetry axes of spheroidal particle pairs, whilst turbulence also promotes an alignment between the interacting particles when compared to the quiescent case.
Fluctuation characteristics and topological interface states in the quasi-periodic structures of shallow-water waves
Authors: Guan Xue , Xiao Boya , Liu Yu , Chen Meng 
Published: May 2024

Abstract

Compared with periodic structures, quasi-periodic structures have superior band gap properties and topological interface states. In this paper, a one-dimensional quasi-periodic Fibonacci water wave metamaterial model that can be used to apply quasi-periodic structures to shallow-water wave systems is presented. The fluctuation characteristics of periodic and quasi-periodic structures are examined using finite element numerical calculations based on the shallow-water wave equation. The research results show that the band characteristics of quasi-periodic structures are complex, enabling flexible control of the propagation of shallow-water waves. Furthermore, the mirror-symmetrical design of Fibonacci quasi-periodic water wave metamaterials was created to engineer the topological interface states in shallow-water wave systems, ultimately achieving successful localization of wave energy. This research will greatly enrich our understanding of topology, expand the potential applications of quasi-periodic structures, and provide new insights for manipulating water waves and harvesting energy.
Organizational Pride and Job Satisfaction among Staff Nurses
Authors: Badran Fawzia M. , Mohamed Eman H. 
Published: May 2024

Abstract

Background Organizational pride and job satisfaction are pivotal in molding nurses' professional journeys within their workplace. When nurses harbor pride in their organization, it frequently translates into elevated levels of job satisfaction.
Aim The present study aimed to assess the relationship between organizational pride and job satisfaction among staff nurses.
Methods A descriptive correlational study was conducted with 169 nurses were included in the study using a simple random sampling method. Two tools, the organizational pride scale and the Minnesota Satisfaction Scale, were used.
Results In this study, the studied subjects reported a moderate perception level of organizational pride (78.1%), followed by a high perception level (11.3%), and the studied subjects reported a moderate level of job satisfaction (66.9%), followed by a low level (20.1%).
Conclusion This study concludedthat the organizational pride of nurses was positively correlated and significantly correlated with job satisfaction (r=.680**, p=0.000). The results of the current study suggest that developing strategies to improve organizational pride among staff nurses and updating policies and procedures for nursing can enrich nurses’ understanding of practice.
Trial Registration Number [TRN] The study proposal was approved by the Research Ethics Committee of the Faculty of Nursing, Ain Shams University (Code Number: NUR 23.12.178).
Long-duration spaceflight adversely affects astronaut piloting performance
Authors: Moore Steven T , Sims Tiffany R , Dilda Valentina , MacDougall Hamish G 
Published: May 2024

Abstract

A group of highly experienced pilots performed full-motion, simulated T-38 landings before and after extended missions aboard the International Space Station (ISS). On the day of return from the ISS pilots’ performance was degraded on the initial landing attempt, with difficulty maintaining altitude during banking turns and navigational errors, which affected touchdown parameters such as touchdown speed, height over runway threshold and touchdown distance from the runway threshold. A positive result was that all pilots successfully completed a second landing attempt on the same day, suggesting a rapid recovery of performance once exposed to the task at hand. These results are consistent with a previous study that demonstrated significant deficits in post-flight driving performance, and both the pilot and driver subjects’ performance recovered to pre-flight levels within four days of return from the ISS. We propose that the primary factors underlying the post-flight performance deficits were the inability to respond appropriately to gravitational and visual tilts and a reduction in multitasking ability.
New Approach for Integrity Risk Evaluation Based on Expected Acceptable Region for Carrier-Phase-Based Precise Relative Positioning
Authors: Li Qingsong , Wang Dingjie , Wu Jie , Wang Lei 
Published: May 2024

Abstract

GNSS carrier-phase observation is widely adopted to achieve centimeter-level relative position accuracy in life-critical or mission-critical GNSS applications. Different from code-based relative positioning, carrier-phase-based precise relative position still suffers from insufficient integrity risk evaluation caused by its inherent risk sources such as cycle slips and ambiguity resolution. This paper proposes a novel integrity risk evaluation approach for relative positioning, especially considering cycle slips. To eliminate cycle slips under the condition of concurrency in multiple channels more efficiently, INS-aided information is adopted for cycle slip detection and elimination. To reduce the difficulty of deriving the post-test variance of observations and simplify the process of integrity risk evaluation, the concept of Expected Acceptable Region (EAR) is first proposed to decompose total integrity risk as two independent components, i.e., intra-EAR risk and extra-EAR risk. Different evaluation algorithms are adopted based on the characteristics of different regions. To verify the superiority of the proposed method, numerical experiments have been conducted to simulate the aircraft's precision approaching and landing, where the proposed algorithm is adopted to meet the strict integrity requirements for Sea-based JPALS. It is indicated that the proposed method can provide both conservative and accurate estimation of integrity risk with a small part of the prior probability of cycle slip (i.e., \(\pm 1\)cycle). Compared with carrier-phase-based relative positioning in the ARAIM frame, the proposed method can increase GNSS availability by about 20% with a significant decrease in computation time by about 76%.
Centenarians, Semi and Supercentenarians, COVID-19 and Spanish Flu: a serological assessment to gain insight into the resilience of older centenarians to COVID- 19
Authors: Trombetta Claudia Maria , Accardi Giulia , Aiello Anna , Calabrò Anna , Caruso Calogero , Ligotti Mattia Emanuela , Marchi Serena , Montomoli Emanuele , Neto Martin Mayora , Temperton Nigel , Candore Giuseppina 
Published: May 2024

Abstract

Background
Although it is well known that the older people have been the most susceptible to COVID-19, there are conflicting data on the susceptibility of centenarians. Two epidemiological study have shown that older centenarians (> 101 years old at the time of the 2020 pandemic peak) are more resilient than the remaining centenarians, suggesting that this resilience might be linked to the 1918 Spanish Flu pandemic. To gain insight into this matter, specifically whether the resilience of older centenarians to SARS-CoV-2 infection is linked to the Spanish Flu they had been affected by, we conducted a retrospective serological study. This study examined serum samples from 33 centenarians, encompassing semi- (aged > 104 < 110 years, N = 7) and supercentenarians (aged > 109 years, N = 4), born between 1905 and 1922, against both SARS-CoV-2 and 1918 H1N1 pseudotype virus.
Results
Anamnestic and laboratory data indicate that SARS-CoV-2 infection occurred in 8 centenarians. The infection appeared to have been asymptomatic or mild, and hospitalization was not required, despite 3 out of 8 being between 109 and 110 years old. The levels of anti-spike antibodies in centenarians infected and/or vaccinated were higher, although not significantly, than those produced by a random sample of seventy-year-old individuals used as controls. All centenarians had antibody levels against the 1918 H1N1 virus significantly higher (almost 50 times) than those observed in the quoted group of seventy-year-old subjects, confirming the key role in maintaining immunological memory from a priming that occurred over 100 years ago. Centenarians whose blood was collected prior to the pandemic outbreak demonstrated neutralising antibodies against the 1918 H1N1 virus, but all these subjects tested negative for SARS-CoV-2.
Conclusion
This retrospective study clearly demonstrates that older centenarians are quite resilient to COVID-19, as they are capable of producing good levels of neutralising antibodies and experiencing mild or asymptomatic disease. This could be attributed to the 1918 Spanish flu pandemic through mechanisms other than the presence of cross-reactive antibodies between the 1918 H1N1 virus and SARS-CoV-2.
Assessment of the impact of offshore wind farm foundations in the English Channel on larval dispersal and connectivity using numerical modeling
Authors: Ajmi Souha , Boutet Martial , Bennis Anne-Claire , Dauvin Jean-Claude 
Published: May 2024

Abstract

This work aims to investigate how the presence of Offshore Wind Farms (OWFs) could have local and potentially regional environmental impacts, as the turbine foundations serve as artificial habitats for various benthopelagic species, creating reef ecosystems. This study investigates how under met-oceanic forcings these farms could control the larval dispersion in the extended Bay of Seine. The dispersion of both natural species (mussel and European green crab) and introduced species (e.g. Japanese oyster and Asian shore crab) is simulated with coupled physical-biological numerical model combining MARS3D and ICHTHYOP. After a successful qualitative validation step using DILEMES data, it is observed that wind farms serve as relay points for species, facilitating connectivity between the farms and the shores of the extended Bay of Seine. Larval dispersal from the wind farms shows connectivity not only between the farms themselves but also between the farms and the shores of the extended Seine Bay, with approximately 7.44$\%$ of initially emitted larvae settling inside the Courseulles-sur-Mer OWF. As expected, the spatial resolution of the hydrodynamic model impacts the results, influencing larval retention particularly at the intersection of different nested grids. Our results indicate that it would be preferable to include effects of OWFs in future coastal management scenarios and underline the need to study cumulative impacts.
Single-cell transcriptomics reveals stage- and side-specificity of gene modules in colorectal cancer
Authors: Rahiminejad Sara , Mukund Kavitha , Maurya Mano Ram , Subramaniam Shankar 
Published: May 2024

Abstract

BACKGROUND: An understanding of mechanisms underlying colorectal cancer (CRC) development and progression is yet to be fully elucidated. This study aims to employ network theoretic approaches to analyse single cell transcriptomic data from CRC to better characterize its progression and sided-ness.
METHODS: We utilized a recently published single-cell RNA sequencing data (GEO-GSE178341) and parsed the cell X gene data by stage and side (right and left colon). Using Weighted Gene Co-expression Network Analysis (WGCNA), we identified gene modules with varying preservation levels (weak or strong) of network topology between early (pT1) and late stages (pT234), and between right and left colons. Spearman’s rank correlation (ρ) was used to assess the similarity or dissimilarity in gene connectivity.
RESULTS: Equalizing cell counts across different stages, we detected 13 modules for the early stage, two of which were non-preserved in late stages. Both non-preserved modules displayed distinct gene connectivity patterns between the early and late stages, characterized by low ρ values. One module predominately dealt with myeloid cells, with genes mostly enriched for cytokine-cytokine receptor interaction potentiallystimulating myeloid cells to participate in angiogenesis. The second module, representing a subset of epithelial cells, was mainly enriched for carbohydrate digestion and absorption, influencing the gut microenvironment through the breakdown of carbohydrates. In the comparison of left vs. right colons, two of 12 modules identified in the right colon were non-preserved in the left colon. One captured a small fraction of epithelial cells and was enriched for transcriptional misregulation in cancer, potentially impacting communication between epithelial cells and the tumor microenvironment. The other predominantly contained B cells with a crucial role in maintaining human gastrointestinal health and was enriched for B-cell receptor signalling pathway.
CONCLUSIONS: We identified modules with topological and functional differences specific to cell types between the early and late stages, and between the right and left colons. This study enhances the understanding of roles played by different cell types at different stages and sides, providing valuable insights for future studies focused on the diagnosis and treatment of CRC.
Genome-wide Identification and Characterization of the STR Gene in Dendrobium officinale
Authors: Ren Xiang , Dong Wenhao , Chen Chen , Song Jingjing , Wei Lianping , Song Cheng , Jin Qing 
Published: May 2024

Abstract

Alkaloids are the main active ingredients in the traditional Chinese medicine Dendrobium spp. Terpenoid indole alkaloids (TIAs), a class of secondary metabolites with a nitrogen heterocyclic structure, are low in content and difficult to synthesize chemically. Strictosidine synthetase (STR) is a key enzyme that catalyzes the Pictet-Spengler reaction of TIAs. However, the molecular characteristics and enzymatic properties of STR proteins in Dendrobium officinale remain unclear. Through bioinformatics analysis, we systematically studied the protein purification and catalytic activity of DoSTR. We initially identified eight STR homologous genes in D. officinale. Members of the DoSTR family vary in molecular weight, theoretical isoelectric point, and subcellular localization. Cis-acting element analysis of the DoSTR promoter revealed the presence of multiple elements involved in phytohormone response and biotic and abiotic stress. Phylogenetic tree and homology alignment revealed that DoSTR proteins are more closely related to STR proteins of Dendrobium huoshanense;however, DoSTR are evolutionarily distant from plant STR proteins with characterized functions, such as CrSTR, RvSTR, and RsSTR. Conservative motif analysis revealed a conserved motif in the STR sequence. The Glu309 residue, which is associated with catalysis, is not conserved. Using qRT-PCR, the expression pattern of DoSTR was found to be spatially specific. Through transient expression in tobacco, DoSTR8 was shown to localize to cell membranes. The DoSTR8 recombinant protein was successfully expressed in E. coli using prokaryotic expression and purified. The findings of this study may provide valuable insights into further research on the function of the STR gene family in D. officinale.
Korean Cerebral Palsy Registry (KCPR): study rationale and protocol of a multicentre prospective cohort study
Authors: Hong Juntaek , Choi Ja Young , Kwon Jeong Yi , Shin Yong Beom , Yang Shin-seung , Jang Dae-Hyun , Yoon Jin A , Rha Dong-wook 
Published: May 2024

Abstract

Background
Cerebral palsy (CP) is a leading cause of motor developmental disability in children. Generating epidemiological data on CP could enable early diagnosis, intervention, and translational research. We aim to establish a Korean network and online data repository for CP called the Korean Cerebral Palsy Registry (KCPR).
Methods
The KCPR is a nationwide, multicentre, prospective cohort study designed as a 20-year longitudinal follow-up of approximately 800 children with CP. Institution-based surveillance mechanisms will be adopted for the registration of children with CP aged less than 7 years to participate in KCPR. The data collection form of the KCPR will comprise diagnostic information, risk factors, extent of disability, genetic data, quality of life, socioeconomic status, functional levels according to life cycle stages, and patterns of healthcare utilisation, including rehabilitation. The study objectives include (1) identifying the pathological characteristics of CP along with their medical, social, economic, and psychological needs and challenges; (2) using data accumulated from prospective tracking of the function and quality of life of children with CP to develop comprehensive service plans and policies that integrate medical care, special education, and welfare; and (3) conducting intervention cohort studies to establish guidelines for the provision of standardised rehabilitative medical services.
Discussion
The establishment of KCPR is crucial to delivering systematic and comprehensive services in the medical, educational, and social sectors throughout the lifecycle of children with CP. KCPR aims to enhance the diagnostic, rehabilitative, and educational approaches for children with CP. Ultimately, this initiative will contribute to advancements in the health and welfare of children with CP.
Diagnose and Classification of Infectious and Diseases using Nano Sensors Network in Nanofluids: Theoretical and Modeling Study
Authors: Boualem Adda , Fouchal Hacène , Ayaida Marwane , Kholidy Hisham 
Published: May 2024

Abstract

There is a real need for a NanoSensor Network to detect infectious, especially incurable diseases today, to distinguish the chemical and behavioral properties of incurable diseases from the behavioral properties of other particles. The proposed nanonetworks are designed to help doctors to diagnose infectious and incurable diseases. Nanofluidics can also increase mass and heat transfer through various media to repair or damage cells, human organs, and tissues based on various technologies such as magnetic hyperthermia treatment or active coatings. For all these reasons, there is a real need for a nano-sensor network for nanofluid environment, for nanomedicine and biomedicine. This work is on the implantation of a nanosensors network in nanofluids: classifications and application in nanomedicine and biomedicine. In the evaluation and analysis phase, we have integrated a comparison with similar works, the limitation of the solution, and we have proposed an algorithm and a model that are used to ensure precision and reliability in the diagnosis of our solution using current technologies. To summarize, this work proposes nanosensor network platforms to help doctors diagnose diseases such as cancer and diabetic patients.