bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluación de la gestión operativa y su influencia en los procesos de producción en las MIPYMES de panificación
Authors: Argueta Martínez Jenny Xiomara 
Published: February 2025

El presente trabajo se realizó en la ciudad de Choluteca, Honduras, en la actividad de manufactura en las micro, pequeñas y medianas empresas (MIPYMES) panificadoras en la ciudad de Choluteca, Honduras, realizando una evaluación de la gestión operativa en general de las 10 funciones de la administración de operaciones. El objetivo general de este trabajo fue realizar una evaluación de la gestión operativa de las micro y pequeñas empresas de la industria de la panificación y su incidencia en los procesos de producción de este sector empresarial. La metodología consistió en un enfoque cuantitativo, un diseño no experimental transeccional-correlacional y un alcance correlacional, se utilizó una encuesta que se aplicó a 25 MiPymes inscrita a la cámara de comercio del sur y se realizó un análisis estadístico de correlaciones de variable y prueba de hipótesis. Los principales resultados, fueron que la mayor parte de los procesos productivos se desarrollan de forma manual es decir no se ha tecnificado la elaboración de los productos, así como la falta de planificación en la producción e inadecuada distribución de las tareas, inexistencia de sistemas de controles, bajo desarrollo tecnológico y pocos canales de distribución. Se identificó que los componentes más relevantes para iniciar un proceso de producción son materias primas, proveedores, equipo, así como que la mecanización de los procesos puede mejorar la producción, también que estos procesos dependen de factores como talento humano, innovación, sistemas de calidad entre otros.
LITERATUR REVIEW JURNAL: ANALISIS TENTANG PENYAKIT MENULAR CACAR MONYET (MPOX) YANG MENYERANG KALANGAN ANAK-ANAK
Authors: Oktaviani Yoneta , Medina Ridha Nur 
Published: February 2025

Monkey pox (monkeypox) is a viral infectious disease caused by viruses in the genus orthopoxvirus. Mpox cases have also been reported in children and adolescents. During 1970-2021, Mpox cases in Central Africa were mostly (54%-90%) reported in children. This journal review aims to find out how the Mpox disease is transmitted to attack humans. The method used is descriptive analysis (systematic literature review) by collecting several journals about MPox infectious diseases. From the results obtained, the analysis shows that the infectious disease monkey pox (Mpox) which attacks humans can be transmitted to children by means of transmission through animals to humans, humans to humans and environmental contamination.

Cacar monyet (monkeypox) merupakan penyakit infeksi virus yang disebabkan oleh virus dengan genus orthopoxvirus. Kasus Mpox juga dilaporkan terjadi pada anak-anak dan remaja. Selama tahun 1970-2021, kasus Mpox di Afrika Tengah sebagian besar (54%-90%) dilaporkan terjadi pada anak-anak. Review jurnal ini bertujuan untuk mengetahui bagaimana penularan penyakit Mpox hingga menyerang manusia. Metode yang digunakan merupakan analisis deskriptif (systematic literature review) dengan mengumpulkan beberapa jurnal tentang penyakit menular MPox. Dari hasil yang diperoleh bahwa analisis tentang penyakir menular cacar monyet (Mpox) yang menyerang manusia sudah dapat menularkan pada anak dengan cara penularan melalui hewan ke manusia, manusia ke manusia dan lingkungan kontaminasi
Hip Hop as Cultural Capital: Remixing Bourdieu's Theory to Affirm Cultural Wealth
Authors: Turner Milanika 
Published: February 2025

Despite their popularity in the United States of America, rap music and hip hop culture are misunderstood by many and often characterized as violent, misogynistic, vulgar, and/or venomous. Furthermore, scholarly examinations of rap music rarely emerge from within the actual culture, even though an insider’s perspective could yield valuable emic knowledge. The objective of this study is to assess the cultural value of hip hop and rap through a content analysis of popular music. Billboard music charts provide data on music trends by compiling the most popular rap songs for six years (2006–2011) ranked by sales, radio airplay, and audience impressions. Stratified random sampling of just over five percent of the population (N = 215) generated the subset for this pilot study (n = 12). Lyrics of all songs in the sample have been analyzed through the lens of Critical Race Theory along six forms of cultural capital identified in literature: aspirational, linguistic, social, familial, resistant, and navigational. This has made it possible to reframe the discourse on hip hop and rap by establishing how the music operates as cultural capital, as well as commands respect for and establishes the legitimacy of the knowledge and products generated within hip hop culture.
Influence of Parental Socio-Cultural Status on Prevention of Teenage Pregnancies in Narok-North Sub-County, Narok County, Kenya
Authors: Akuno Elon M. , Okello Lazarus Millan , Otengah Wilson A. P. 
Published: February 2025

Teenage pregnancy is detrimental to the wellbeing of teenage girls because of its negative impact on health, social and educational outcomes. Parents may encounter challenges that prevent them from helping their daughters in preventing pregnancies. Therefore, the study aimed to investigate influence of parental socio-cultural status on prevention of teenage pregnancies. The study was guided by the Social Network Theory. Descriptive Cross-Sectional Survey Design and Mixed Method approach directed the study. The target population of the research was 59,996 families in Narok-North Sub- County. Snowball sampling was applied to obtain a sample size of 165 families from the target population. Simple random sampling was applied to get 10 Key Informants. Data was collected using questionnaires and interview schedules. Internal consistency was calculated to test the reliability of the questionnaire with a reliability coefficient of 0.85. Validity was confirmed with the help of experts from the department and in training of Research Assistants. Data was examined by use of SPSS version 26.0. The Pearson Correlation test revealed that parental socio-cultural status has moderate and positive influence on prevention of teenage pregnancy (at P value <.05 Mean r = .54). Majority (82.6%) of respondents endorsed that cultural norms encourage early marriages. Majority (42.9%) of respondents endorsed that teenagers get into sexual relationships in order to meet basic needs. This aligns with the assumption of the Social Network Theory’s application to this study, that the family unit’s outcome in terms of teenage pregnancies is influenced by the cultural norms that surround the respondents. The Study therefore recommends that the Ministry of Interior and National Administration to strengthen policy aimed at curbing cultural practices that predispose teenage girls to pregnancies.
Pollination Strategies for Advancing Protected Cultivation of Vegetable Crops
Authors: Athira K S , Pradeepkumar T 
Published: February 2025

Protected cultivation is a transformative agrotechnology offering enhanced yield, quality, and resource efficiency. Pollination, a critical determinant of crop productivity, faces unique challenges in controlled environments, necessitating innovative strategies. This review highlights various pollination techniques, including manual, mechanical, and biotic methods, and their application in vegetable crop cultivation. While manual methods like hand pollination ensure precision, they are labor-intensive. Mechanical solutions, such as handheld vibrators, air blowers, and electrostatic devices, provide scalable alternatives but often lack the efficiency of natural pollinators. Biotic agents, including bumblebees, honeybees, stingless bees, and solitary species like carpenter bees and Australian blue-banded bees, emerge as sustainable and effective solutions. Their adaptability to greenhouse conditions and selective pollen transfer capabilities significantly enhance fruit set, quality, and yield. Emerging technologies, such as robotic pollinators and pulsating air systems, further complement traditional methods. This review underscores the importance of integrating diverse pollination strategies to optimize productivity in protected cultivation systems.
Co‐inoculation of Azospirillum brasilense and late nitrogen fertilization for no‐till soybean production
Authors: Caires Eduardo Fávero , Bini Angelo Rafael , Duart Vanderson Modolon , Ricardo Kaynnã da Silva , Alves Lucas Maurício 
Published: May 2024

AbstractSoybean [Glycine max (L.) Merr.] is highly efficient in the biological N2 fixation (BNF) process through the association of bacteria of the genus Bradyrhizobium in the root nodules of the plants. However, there are still doubts about the need to complement soybean N demand through N fertilization in high‐yield environments. In addition, the real impact of co‐inoculation of soybean with Azospirillum brasilense and Bradyrhizobium spp. is not yet clear in such environments. A field experiment was conducted from 2012 to 2021 with six soybean cropping seasons in a crop rotation scheme with black oat (Avena strigosa Schreb), maize (Zea mays L.), and wheat (Triticum aestivum L.) under no‐till (NT) in Southern Brazil. Soybean seeds were co‐inoculated with A. brasilense (strains Ab‐V5 and Ab‐V6) shortly after inoculation with Bradyrhizobium japonicum, and different levels of N fertilization were used in top dressing at the start of pod formation (R3). Soybean nutritional status and grain yield were not benefited by co‐inoculation with A. brasilense. Since the increased inoculum rate of A. brasilense co‐inoculated with rhizobia in soybean compromised both N nutrition and grain yield, this practice should not be encouraged. There was no need to complement soybean N demand through N fertilization during the reproductive stage. Soybean achieved grain yields of 5.0–5.7 Mg ha−1 and, even so, there was no need to complement N demand through N fertilization. The results suggest that soybean N demand in a high‐yielding environment under NT could be satisfied exclusively through the optimization of BNF.
Porous Organic Polymers for Efficient and Selective SO2 Capture from CO2‐rich Flue Gas
Authors: Jia Jiangtao , Bhatt Prashant M. , Tavares Sergio R. , Abou‐Hamad Edy , Belmabkhout Youssef , Jiang Hao , Mallick Arijit , Parvatkar Prakash T. , Maurin Guillaume , Eddaoudi Mohamed 
Published: May 2024

AbstractThe quest for effective technologies to reduce SO2 pollution is crucial due to its adverse effects on the environment and human health. Markedly, removing a ppm level of SO2 from CO2‐containing waste gas is a persistent challenge, and current technologies suffer from low SO2/CO2 selectivity and energy‐intensive regeneration processes. Here using the molecular building blocks approach and theoretical calculation, we constructed two porous organic polymers (POPs) encompassing pocket‐like structures with exposed imidazole groups, promoting preferential interactions with SO2 from CO2‐containing streams. Markedly, the evaluated POPs offer outstanding SO2/CO2 selectivity, high SO2 capacity, and an easy regeneration process, making it one of the best materials for SO2 capture. To gain better structural insights into the notable SO2 selectivity of the POPs, we used dynamic nuclear polarization NMR spectroscopy (DNP) and molecular modelling to probe the interactions between SO2 and POP adsorbents. The newly developed materials are poised to offer an energy‐efficient and environment‐friendly SO2 separation process while we are obliged to use fossil fuels for our energy needs.
Biocatalytic Nucleobase Diversification of 4′‐Thionucleosides and Application of Derived 5‐Ethynyl‐4′‐thiouridine for RNA Synthesis Detection
Authors: Westarp Sarah , Benckendorff Caecilie M. M. , Motter Jonas , Röhrs Viola , Sanghvi Yogesh S. , Neubauer Peter , Kurreck Jens , Kurreck Anke , Miller Gavin J. 
Published: May 2024

AbstractNucleoside and nucleotide analogues have proven to be transformative in the treatment of viral infections and cancer. One branch of structural modification to deliver new nucleoside analogue classes explores replacement of canonical ribose oxygen with a sulfur atom. Whilst biological activity of such analogues has been shown in some cases, widespread exploration of this compound class is hitherto hampered by the lack of a straightforward and universal nucleobase diversification strategy. Herein, we present a synergistic platform enabling both biocatalytic nucleobase diversification from 4′‐thiouridine in a one‐pot process, and chemical functionalization to access new entities. This methodology delivers entry across pyrimidine and purine 4′‐thionucleosides, paving a way for wider synthetic and biological exploration. We exemplify our approach by enzymatic synthesis of 5‐iodo‐4′‐thiouridine on multi‐milligram scale and from here switch to complete chemical synthesis of a novel nucleoside analogue probe, 5‐ethynyl‐4′‐thiouridine. Finally, we demonstrate the utility of this probe to monitor RNA synthesis in proliferating HeLa cells, validating its capability as a new metabolic RNA labelling tool.
Puerarin alleviates acrolein‐induced atherosclerosis by activating the MYH9‐mediated SIRT1/Nrf2 cascade to inhibit the activation of inflammasome
Authors: Li XiaoNing , Li YeTing , Jiao HuiHui , Wang AiTing , Zheng Man , Xiang ChunYan , Zhang FengLei 
Published: May 2024

AbstractPuerarin (Pue) has significant antioxidant and anti‐inflammatory properties. This work was designed to clarify and investigate the potential mechanisms of Pue in atherosclerosis (AS) progression.In vivo, acrolein (Acr) was inhaled through drinking water to construct AS model. In vitro, CCK‐8 assay and lactate dehydrogenase (LDH) assay kit were used to detect cell viability. Apoptosis was detected by flow cytometry. The content of malondialdehyde (MDA) was determined by commercial kit, the level of inflammatory factors was detected by ELISA, and proteins were determined by western blot. Pue administration could effectively reduce blood lipid level in Acr‐fed mice. Pue suppressed oxidative stress, the formation of atherosclerotic plaques, and the process of aortic histological changes. Pue pretreatment decreased MDA in HUVECs and maintained the activity of antioxidant enzymes. Pue upregulated SIRT1/Nrf2 cascade in HUVECs. Pue increased MYH9 and inhibited NLRP3 inflammasome‐related proteins, and the inhibition of MYH9 significantly impaired Pue‐induced Nrf2 activation. Moreover, HUVEC cytotoxicity and apoptosis are alleviated by Pue, in addition to NLRP3‐mediated pyroptosis in HUVECs induced by Acr. MYH9 inhibitors effectively suppressed the pyroptosis induced by Acr and prevented injury to HUVECs. In addition, Pue promoted SIRT1/Nrf2 cascade activation in HUVECs. Pue may alleviate Acr‐induced AS by activating the MYH9‐mediated SIRT1/Nrf2 cascade to inhibit inflammasome activation.
A qualitative study on redefining normality in relatives of patients with advanced cancer
Authors: Driessen Helen P. A. , Bakker Evi M. , Rietjens Judith A. C. , Luu Khanh L. N. , Lugtenberg Marjolein , Witkamp Frederika E. , Kranenburg Leonieke W. 
Published: May 2024

AbstractObjectiveTo obtain insight into adaptation processes of redefining normality and its influencing factors in relatives of patients with advanced cancer.MethodsAn exploratory qualitative study among relatives of patients with advanced cancer was conducted. Participants were purposively recruited. Ten in‐depth individual (relative only) and 16 dyad (relative and patient together) interviews were conducted, transcribed verbatim, and analyzed by means of thematic analysis, drawing on elements of grounded theory, combining both inductive and deductive elements.ResultsTwo adaptation processes of (redefining) normality were identified: assimilation and accommodation. The latter was found to be the main way of adapting to new events. Assimilative coping strategies entailed “continuing to do the same activities as done before the disease,” “difficulty accepting the situation,” “avoiding to think about the disease,” and “living in the short term.” Accommodative strategies involved “arranging practical matters,” “thinking about the future,” “doing what is feasible,” “engaging in new activities,” “accepting the situation,” “seeking distraction,” “living in the short term,” and “focusing on what truly matters in life.” The interplay between the diagnosis and treatment of cancer, a deteriorating disease status, and the accompanying uncertainty about the future was of influence on the relatives' coping strategies.ConclusionWhen the new situation is too divergent to assimilate, accommodation may be necessary for relatives to cope with the growing complexity of the consequences of their loved one's illness. Accommodative coping then involves accepting the changing reality and actively making the necessary adjustments to build resilience and cope with the new circumstances.
A novel nomogram based on inflammation biomarkers for predicting radiation cystitis in patients with local advanced cervical cancer
Authors: Lin Jie , Lin Jiexiang , Liu Linying , Xie Ning , Yu Haijuan , Deng Sufang , Sun Yang 
Published: May 2024

AbstractBackgroundsPlatelet‐to‐albumin ratio (PAR) is a new systemic inflammatory prognostic indicator associated with many inflammatory diseases. However, its role in radiation cystitis (RC) is obscure. This study aimed to explore whether PAR could be used as an effective parameter for predicting the RC risk in local advanced cervical cancer (CC) treated with radiotherapy.MethodsA total of 319 local advanced CC patients who received radical radiotherapy at Fujian Cancer Hospital were enrolled between December 2018 and January 2021. Demographics and clinical parameters were retrospectively analyzed. Univariate and multivariate analyses were used to identify the risk factors for RC. Backward and stepwise regression was applied to construct two monograms‐one with primary significant factors and the other with extra inflammatory biomarkers. A DeLong test was applied to compare the prediction abilities of two nomograms. Calibration curves and decision curve analysis (DCA) evaluated its prediction consistency, discrimination ability, and clinical net benefit.ResultsUnivariate analysis showed that age, tumor size, stage, total radiation dose, pelvic radiation dose, Systemic Immune‐Inflammation Index (SII), platelet‐to‐lymphocyte ratio (PLR), and PAR were significantly associated with RC occurrence (all p < 0.05). Multivariate analyses indicated that age, tumor size, stage, total radiation dose, and PAR were independent factors (all p < 0.05). Then, the area under curve (AUC) value of the nomogramSII+PAR was higher (AUC = 0.774) compared to that of the baseline nomogram (AUC = 0.726) (pDelong = 0.02). Also, the five‐cross validation confirmed the stability of the nomogramSII+PAR. Moreover, the calibration curve and DCA exhibited the nomograms' good prediction consistency and clinical practicability.ConclusionsPAR and SII could be valued for CC patients who are treated with radiation therapy. The nomogram based on PAR and SII could stratify patients who need extra intervention and nursing care to prevent bladder radiation damage and improve patients' quality of life.
Exploration of Rhenium Bisquinoline Tricarbonyl Complexes for their Antibacterial Properties
Authors: Fulgencio Sofia , Scaccaglia Mirco , Frei Angelo 
Published: May 2024

AbstractMetal complexes have emerged as a promising source for novel classes of antibacterial agents to combat the rise of antimicrobial resistance around the world. In the exploration of the transition metal chemical space for novel metalloantibiotics, the rhenium tricarbonyl moiety has been identified as a promising scaffold. Here we have prepared eight novel rhenium bisquinoline tricarbonyl complexes and explored their antibacterial properties. Significant activity against both Gram‐positive and Gram‐negative bacteria was observed. However, all complexes also showed significant toxicity against human cells, putting into question the prospects of this specific rhenium compound class as metalloantibiotics. To better understand their biological effects, we conduct the first mode of action studies on rhenium bisquinoline complexes and show that they are able to form pores through bacterial membranes. Their straight‐forward synthesis and tuneability suggests that further optimisation of this compound class could lead to compounds with enhanced bacterial specificity.
A rare case of heme oxygenase deficiency: A case report and literature review
Authors: Alla Sai Santhosha Mrudula , Agarwal Pahel , Shah Dhruv J. , Shajahan Waseem Abrar , Ramsundar Rakshna , Alla Deekshitha , Ravulapalli Madhavi , Bora Satya , Pillai Sanjay , Bayeh Ruth G. , Repalle Uday Kumar , Suhani Fnu 
Published: May 2024

Key Clinical MessageHeme oxygenase deficiency, a rare condition disrupting heme metabolism, has only nine reported cases. We present a 3‐year‐old boy with dysmorphic facies, asplenia, and normal bilirubin levels despite ongoing hemolysis. Blood transfusions sustained hemoglobin while IV steroids managed inflammation.
Cobalt(II)‐Nitromethane Complex as an Efficient Catalyst Of Demanding Diels‐Alder Reactions on the Example of an Anthracene‐Chalcone System
Authors: Jadwiszczak Michał J. , Nawrocka Ewa K. , Kwiatkowski Piotr , Leszczyński Piotr J. , Malinowski Przemysław J. 
Published: May 2024

AbstractDiels‐Alder (DA) cycloaddition of chalcones to anthracene and its 9‐substituted derivatives is an example of a demanding reaction that is not effective even under increased pressure. In this article we show that an easily accessible complex cation [Co(CH3NO2)6]2+ stabilized by weakly coordinating anion [Al(OC(CF3)3)4]− exhibits good catalytic activity in the reaction. Our screening covering chalcone and anthracene derivatives with either activating or deactivating effects on reactivity in DA cycloadditions show that the catalyst allows to obtain [4+2] cycloadducts with yields up to 99 % under mild conditions, even for 9‐bromoanthracene – a very poor diene in DA reactions. The reaction proceeds best in liquid SO2, which is an unusual solvent for this type of reaction. 9‐methylanthracene ‐ the most reactive diene among those tested in the study ‐ gives two regioisomeric cycloadducts and their ratio depends on the solvent used. Modeling of the reaction with DFT methods shows that Co(II) significantly lowers the activation energy of the cycloaddition. In the case of 9‐bromoanthracene the effect is much more pronounced than with e. g. recently reported redox‐activation of the diene, which is in agreement with much better yields obtained with the use of the cobalt catalyst.