bluuebunny/crossref_metadata_2025_split huggingface dataset:
δ‐Catenin promotes malignant phenotype of non‐small cell lung cancer by non‐competitive binding to E‐cadherin with p120ctn in cytoplasm
Authors: Zhang Jun‐Yi , Wang Yan , Zhang Di , Yang Zhi‐Qiang , Dong Xin‐Jun , Jiang Gui‐Yang , Zhang Peng‐Xin , Dai Shun‐Dong , Dong Qian‐Ze , Han Yang , Zhang Sheng , Cui Quan‐Zhe , Wang En‐Hua 
Published: June 2010

AbstractAs a member of the catenin family, little is known about the clinical significance and possible mechanism of δ‐catenin expression in numerous tumours. We examined the expression of δ‐catenin by immunohistochemistry in 115 cases of non‐small cell lung cancer (NSCLC) (including 65 cases with follow‐up records and 50 cases with paired lymph node metastasis lesions). The mRNA and protein expression of δ‐catenin was also detected in 30 cases of paired lung cancer tissues and normal lung tissues by RT‐PCR and western blotting, respectively. Co‐immunoprecipitation was used to examine whether δ‐catenin competitively bound to E‐cadherin with p120ctn in lung cancer cells or not. The effects of δ‐catenin on the activity of small GTPases and the biological behaviour of lung cancer cells were explored by pull‐down assay, flow cytometry, MTT, and Matrigel invasive assay. The results showed that the mRNA and protein expression of δ‐catenin was increased in lung cancer tissues; the positive expression rate of δ‐catenin was significantly increased in adenocarcinoma, stage III–IV, paired lymph node metastasis lesions, and primary tumours with lymph node metastasis (all p < 0.05); and the postoperative survival period of patients with δ‐catenin‐positive expression was shorter than that of patients with δ‐catenin‐negative expression (p < 0.05). No competition between δ‐catenin and p120ctn for binding to E‐cadherin in cytoplasm was found in two lung cancer cell lines. By regulating the activity of small GTPases and changing the cell cycle, δ‐catenin could promote the proliferation and invasion of lung cancer cells. We conclude that δ‐catenin is an oncoprotein overexpressed in NSCLC and that increased δ‐catenin expression is critical for maintenance of the malignant phenotype of lung cancer. Copyright © 2010 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
The use of prescription medicines and self‐medication among children—a population‐based study in Finland
Authors: Ylinen Sanna , Hämeen‐Anttila Katri , Sepponen Kati , Lindblad Åsa Kettis , Ahonen Riitta 
Published: June 2010

AbstractPurposeThe aim of this study was to investigate the prevalence and concomitant use of prescription medicines and self‐medication, including over‐the‐counter (OTC) medicines, vitamins, and complementary and alternative medicines (CAMs) among Finnish children aged under 12 years.MethodsWe carried out a nationwide postal survey of the use of medicines by a representative sample (n = 6000) of Finnish children aged under 12 years in spring 2007. A response rate of 67% (n = 4032) was achieved. The current use of prescription medicines and the use of OTC medicines, vitamins, and CAMs in the preceding 2 days were the main outcome measures.ResultsIn total, 17% of children had used prescription medicines and 50% some self‐medication. The corresponding figures for OTC medicines, vitamins, and CAMs use were 17, 37, and 11%, respectively. Drugs for obstructive airway diseases were the most common prescription medicines, whereas analgesics and antipyretics, including non‐steroidal‐anti‐inflammatory‐medicines (NSAID), were the most common OTC medicines reported. Vitamin D was the most common vitamin, while fish oils and fatty acids were the most common CAMs used. Ten percent of the children had used prescription medicines and self‐medication concomitantly.ConclusionsMost of the children's medication consists of self‐medication, and especially of vitamin use. However, also a considerable proportion had used prescription medicines, and a minority prescription medicines and self‐medication concomitantly. In three of the cases, a combination of prescription and OTC medicine with a potential risk for interactions were found. Physicians should be aware of this wide use of self‐medication when prescribing medicines. Copyright © 2010 John Wiley & Sons, Ltd.
Adaptive logic‐based switching fault‐tolerant controller design for nonlinear uncertain systems
Authors: Ma Hong‐Jun , Yang Guang‐Hong 
Published: June 2010

AbstractThis paper deals with the problem of fault‐tolerant control (FTC) for a class of nonlinear uncertain systems against actuator faults using adaptive logic‐based switching control method. The uncertainties under consideration are assumed to be dominated by a bounding system which is linear in growth in the unmeasurable states but can be a continuous function of the system output, with unknown growth rates. Several types of common actuator faults, e.g., bias, loss‐of‐effectiveness, stuck and hard‐over faults are integrated by a unified fault model. By utilizing a novel adaptive logic‐based switching control scheme, the actuator faults can be detected and automatically accommodated by switching from the stuck actuator to the healthy or even partly losing‐effectiveness one with bias, in the presence of large parametric uncertainty. In particular, two switching logics for updating the gain in the output feedback controllers are designed to ensure the global stability of the nominal (fault‐free) system and the boundedness of all closed‐loop signals of the faulty system, respectively. Two simulation examples of an aircraft wing model and a single‐link flexible‐joint robot are given to show the effectiveness of the proposed FTC controller. Copyright © 2010 John Wiley & Sons, Ltd.
Stabilization of networked control systems with nonuniform random sampling periods
Authors: Yang Hongjiu , Xia Yuanqing , Shi Peng 
Published: June 2010

AbstractIn this paper, a new linear delayed delta operator switched system model is proposed to describe networked control systems with packets dropout and network‐induced delays. The plant is a continuous‐time system, which is sampled by time‐varying random sampling periods. A general delta domain Lyapunov stability criterion is given for delta operator switched systems with time delays. Sufficient conditions for asymptotic stability of closed‐loop networked control systems with both packets dropout and network‐induced delays are presented in terms of linear matrix inequalities (LMIs). A verification theorem is given to show the solvability of the stabilization conditions by solving a class of finite LMIs. Both the case of data packets arrive instantly and the case of invariant sampling periods in delta operator systems are given, respectively. Three numerical examples are given to illustrate the effectiveness and potential of the developed techniques. Copyright © 2010 John Wiley & Sons, Ltd.
Adaptive NN output‐feedback decentralized stabilization for a class of large‐scale stochastic nonlinear strict‐feedback systems
Authors: Li Jing , Chen Weisheng , Li Jun‐Min 
Published: June 2010

AbstractIn this paper, the decentralized adaptive neural network (NN) output‐feedback stabilization problem is investigated for a class of large‐scale stochastic nonlinear strict‐feedback systems, which interact through their outputs. The nonlinear interconnections are assumed to be bounded by some unknown nonlinear functions of the system outputs. In each subsystem, only a NN is employed to compensate for all unknown upper bounding functions, which depend on its own output. Therefore, the controller design for each subsystem only need its own information and is more simplified than the existing results. It is shown that, based on the backstepping method and the technique of nonlinear observer design, the whole closed‐loop system can be proved to be stable in probability by constructing an overall state‐quartic and parameter‐quadratic Lyapunov function. The simulation results demonstrate the effectiveness of the proposed control scheme. Copyright © 2010 John Wiley & Sons, Ltd.
A second‐generation architecture for Linux DVB networking
Authors: Prähauser C. , Collini‐Nocker B. 
Published: June 2010

AbstractIP over Digital Video Broadcasting (DVB) operating system support for the second‐generation DVB physical carriers is still limited to the so‐called broadcast profile that supports only Constant Coding and Modulation mode and encapsulation of IP packets into MPEG‐2 Transport Stream packets. Both multi‐protocol encapsulation and unidirectional lightweight encapsulation are currently used encapsulations therefore. The interactive profile, in contrast, provides a generic stream interface that allows for efficient use also in Variable Coding and Modulation and Adaptive Coding and Modulation mode and provides with Generic Stream Encapsulation a new encapsulation. This study presents a novel architecture for Linux kernel‐based operating systems to support second‐generation DVB carriers. Copyright © 2010 John Wiley & Sons, Ltd.
3D CFD computations of transitional flows using DES and a correlation based transition model
Authors: Sørensen Niels N. , Bechmann A. , Zahle F. 
Published: June 2010

AbstractThe present article describes the application of the correlation based transition model of Menter et al. in combination with the Detached Eddy Simulation (DES) methodology to two cases with large degree of flow separation typically considered difficult to compute. Firstly, the flow is computed over a circular cylinder from Re = 10 to 1 × 106 reproducing the cylinder drag crisis. The computations show good quantitative and qualitative agreement with the behaviour seen in experiments. This case shows that the methodology performs smoothly from the laminar cases at low Re to the turbulent cases at high Re. Secondly, the flow is computed over a thick airfoil at high angle of attack, in this case the DU‐96‐W351 is considered. These computations show that a transition model is needed to obtain correct drag predictions at low angle of attack, and that the combination of transition and the DES method improve agreement in the deep stall region. Copyright © 2010 John Wiley & Sons, Ltd.
Trying on and Trying Out: Participatory Action Research as a Tool for Literacy and Identity Work in Middle Grades Classrooms
Authors: Van Sluys Katie 
Published: June 2010

AbstractThis article explores the role of collaborative, ethnographic, participatory action research (PAR) with eighth grade students as a set of possible literacy practices for involving students with issues connected to their lives, resources, language(s), and communities. Findings are based on a year of fieldwork conducted as part of shared inquiry into one public school community's experiences with gentrification and meeting the complex needs of diverse learners. Findings bring to life the ways in which PAR facilitates the redefining of reading, writing, and research; the reconsideration of languages; the rethinking of literacy practices; and the repositioning of participants within and beyond given research endeavors.
Community‐Level Social Support Responses in a Slow‐Motion Technological Disaster: The Case of Libby, Montana
Authors: Cline Rebecca J. W. , Orom Heather , Berry-Bobovski Lisa , Hernandez Tanis , Black C. Brad , Schwartz Ann G. , Ruckdeschel John C. 
Published: June 2010

AbstractSocial support is an important resource for communities experiencing disasters. However, a disaster's nature (rapid‐ versus slow‐onset, natural versus technological) may influence community‐level responses. Disaster research on social support focuses primarily on rapid‐onset natural disasters and, to a lesser extent, rapid‐onset technological disasters. Little research has addressed slow‐onset disasters. This study explores social support processes in Libby, MT, a community experiencing a “slow‐motion technological disaster” due to widespread amphibole asbestos exposure. A comprehensive social support coding system was applied to focus‐group and in‐depth‐interview transcripts. Results reveal that, although the community has a history of normative supportiveness during community and individual crises, that norm has been violated in the asbestos disaster context. Results are interpreted as a failure to achieve an “emergent altruistic community.” Specifically, community‐level conflict appears to interfere with previously established social support patterns. The observed phenomenon can be understood as the deterioration of a previously supportive community.
Links between self‐reported media violence exposure and teacher ratings of aggression and prosocial behavior among German adolescents
Authors: Krahé Barbara , Möller Ingrid 
Published: June 2010

ABSTRACTThe relations between adolescents’ habitual usage of media violence and their tendency to engage in aggressive and prosocial behavior in a school setting were examined in a cross‐sectional study with 1688 7th and 8th graders in Germany who completed measures of violent media exposure and normative acceptance of aggression. For each participant, ratings of prosocial and aggressive behavior were obtained from their class teacher. Media violence exposure was a unique predictor of teacher‐rated aggression even when relevant covariates were considered, and it predicted prosocial behavior over and above gender. Path analyses confirmed a direct positive link from media violence usage to teacher‐rated aggression for girls and boys, but no direct negative link to prosocial behavior was found. Indirect pathways were identified to higher aggressive and lower prosocial behavior via the acceptance of aggression as normative. Although there were significant gender differences in media violence exposure, aggression, and prosocial behavior, similar path models were identified for boys and girls.
Expanding the Role of Nonclinical Personnel in the OR
Authors: Hemingway Maureen , Freehan Marion , Morrissey Lisa 
Published: June 2010

AbstractIdeally, quality health care should be accessible, affordable, and equitable. Working toward these goals in the OR necessitates examining and redesigning work processes and nursing workflow to make better use of the education and skills of perioperative nurses and assistive personnel. This article describes a pilot project undertaken in the OR at Massachusetts General Hospital, Boston, to identify tasks that took nurses away from direct patient care and to better incorporate assistive personnel into the workflow to increase nurses' contact with patients. The pilot program resulted in an expanded role for assistive personnel and more direct patient contact for nurses.
Clinical Issues—June 2010
Authors: Denholm Bonnie , Burlingame Byron 
Published: June 2010

This MonthMeasuring radiation exposure levelsKey words: measuring radiation levels, radiation dosimeters, radiation monitoring, radiation exposure, radiology, workplace safety.Defining major and minor surgical proceduresKey words: major surgical procedures, minor surgical procedures.Comparative evaluation for purchasing new products or equipmentKey words: purchasing process, prepurchase requirements, ongoing product evaluation.Selecting replacement items for discontinued productsKey words: product selection process, replacement product selection, discontinued products, unavailable products.
Assessing changes in flow velocimetry and clinical outcome following use of an external aortic compression device in women with postpartum hemorrhage
Authors: Soltan Mohamed H. , Imam Hisham H. , Zahran Khalid A. , Atallah Suad M. 
Published: June 2010

AbstractObjectiveTo monitor femoral artery blood flow by Doppler velocimetry in women treated for postpartum hemorrhage (PPH) with and without the adjunction of the External Aortic Compression Device (EACD), and to assess the possible adverse effects of the device.MethodsBlood flow velocity in the femoral artery, as well as skin color and sensory or motor changes in the lower limbs, were assessed in 120 women with primary PHH of any cause, quasi randomized to either treatment group. Pulse rate, oxygen saturation, respiratory rate, urinary output, and gastrointestinal symptoms were checked in the study group.ResultsWhile blood flow velocity was significantly less in the study group than control group (P < 0.001), the lowest flow volume velocity of 310.40 mL/sec exceeded the acceptable minimum after device application. The intensity of abdominal discomfort correlated with body mass index. No device complications were observed.ConclusionThe EACD contributed safely and effectively to the treatment of 60 women with PPH of different causes.
The Inevitable Lightening of Citizenship
Authors: Joppke Christian 
Published: June 2010

AbstractThis paper scrutinizes the paradox of the increasing objective yet diminishing subjective value of citizenship in Western states. The decreasing subjective value points to an inevitable lightening of citizenship, which persists despite states’ recent efforts to upgrade and re-nationalize citizenship by ceremony, civic integration tests, and more exclusive rights. I discuss some features of citizenship light, most notably instrumentalism and a dissociation of citizenship from nationhood. The recently court-empowered European Union citizenship serves as an illustration.
Procedure Weak or Strong Understanding the Limits of Political Inquiries
Authors: Schank Jan , Michaeler Matthias , Scheffer Thomas 
Published: June 2010

AbstractThe authors contrast two political inquiries in light of Luhmann’s system theory of procedure. The article asks whether and to what extent these inquiries can be considered as procedural systems, meaning as distinct frames of action that generate specific meanings and relevancies. Starting from the micro-sociological analysis of interactions in the British “Hutton Inquiry” and the European Union’s “CIA Inquiry” the authors reconstruct the specific functionalities of each with regard to their different ways of engaging and enabling self-referential processes of communication, knowledge production, and decision-making. As a system, each merges these three processes into a consistent, relatively strong or weak procedure, but they do so to different degrees. Overall, the article encourages a sociological understanding of the procedural mechanism as well as an empirical qualification and variation of system-theoretical assertions.
Variation of human milk oligosaccharides in relation to milk groups and lactational periods
Authors: Thurl Stephan , Munzert Manfred , Henker Jobst , Boehm Günther , Müller-Werner Beate , Jelinek Jürgen , Stahl Bernd 
Published: June 2010

Human milk oligosaccharides, representing the third largest fraction of human milk, have been assigned important protective functions for newborns acting as bifidogenic substrates or as inhibitory agents towards pathogens. Using high-pH anion-exchange chromatography and an enzyme test kit, twenty oligosaccharides and lactose were determined in milk samples of German women from days 3 to 90 postpartum. Twenty-two secretor mothers with Lewis blood group Le(a − b+) synthesised all twenty oligosaccharides, and could be assigned to milk group 1. Five non-secretor mothers (Le(a+b − )) produced all oligosaccharides with the exception of α1,2-fucosylated compounds (milk group 2), whereas three secretor mothers with blood type Le(a − b − ) lacked α1,4-fucosyloligosaccharides, corresponding to milk group 3. Secretor women of milk groups 1 and 3 synthesised significantly higher amounts of total neutral oligosaccharides and of several total core structures (e.g. lacto-N-tetraose) than non-secretor women. Generally, these oligosaccharides significantly decrease during the first 3 months postpartum. By comparing fucosyloligosaccharides within and among the three milk groups, insight into their biosynthesis could be gained. Six acidic oligosaccharides without fucose residues were detected in milk samples of all mothers. Regression analysis confirmed that total acidic oligosaccharides declined threefold during the study period. Milk samples corresponding to the three milk groups exhibited significant qualitative and quantitative differences during the first 3 months of lactation. It can be assumed that particularly milk of non-secretor women (milk group 2) exerts a modified biological protection in the babies in comparison with milks of secretors (groups 1 and 3).
UK Food Standards Agency Workshop Report: an investigation of the relative contributions of diet and sunlight to vitamin D status
Authors: Ashwell Margaret , Stone Elaine M. , Stolte Heiko , Cashman Kevin D. , Macdonald Helen , Lanham-New Susan , Hiom Sara , Webb Ann , Fraser David 
Published: June 2010

The UK Food Standards Agency (FSA) convened an international group of scientific experts to review three Agency-funded projects commissioned to provide evidence for the relative contributions of two sources, dietary vitamin D intake and skin exposure to UVB rays from sunlight, to vitamin D status. This review and other emerging evidence are intended to inform any future risk assessment undertaken by the Scientific Advisory Committee on Nutrition. Evidence was presented from randomised controlled trials to quantify the amount of vitamin D required to maintain a serum 25-hydroxy vitamin D (25OHD) concentration >25 nmol/l, a threshold that is regarded internationally as defining the risk of rickets and osteomalacia. Longitudinal evidence was also provided on summer sunlight exposure required to maintain 25OHD levels above this threshold in people living in the British Isles (latitude 51°–57°N). Data obtained from multi-level modelling of these longitudinal datasets showed that UVB exposure (i.e. season) was the major contributor to changes in 25OHD levels; this was a consistent finding in two Caucasian groups in the north and south of the UK, but was less apparent in the one group of British women of South Asian origin living in the south of the UK. The FSA-funded research suggested that the typical daily intake of vitamin D from food contributed less than UVB exposure to average year-round 25OHD levels in both Caucasian and Asian women. The low vitamin D status of Asian women has been acknowledged for some time, but the limited seasonal variation in Asian women is a novel finding. The Workshop also considered the dilemma of balancing the risks of vitamin D deficiency (from lack of skin exposure to sunlight in summer) and skin cancer (from excessive exposure to sunlight with concomitant sunburn and erythema). Cancer Research UK advises that individuals should stay below their personal sunburn threshold to minimise their skin cancer risk. The evidence suggests that vitamin D can be produced in summer at the latitude of the UK, with minimal risk of erythema and cell damage, by exposing the skin to sunlight for a short period at midday, when the intensity of UVB is at its daily peak. The implications of the new data were discussed in the context of dietary reference values for vitamin D for the general population aged 4–64 years. Future research suggestions included further analysis of the three FSA-funded studies as well as new research.