bluuebunny/crossref_metadata_2025_split huggingface dataset:
Deciphering the ferroptosis pathways in dorsal root ganglia of Friedreich ataxia models. The role of LKB1/AMPK, KEAP1, and GSK3β in the impairment of the NRF2 response
Authors: Sanz-Alcázar Arabela , Portillo-Carrasquer Marta , Delaspre Fabien , Pazos-Gil Maria , Tamarit Jordi , Ros Joaquim , Cabiscol Elisa 
Published: May 2024

ABSTRACTFriedreich ataxia (FA) is a rare neurodegenerative disease caused by decreased levels of the mitochondrial protein frataxin. Frataxin has been related in iron homeostasis, energy metabolism, and oxidative stress. Ferroptosis has recently been shown to be involved in FA cellular degeneration; however, its role in dorsal root ganglion (DRG) sensory neurons, the cells that are affected the most and the earliest, is mostly unknown. In this study, we used primary cultures of frataxin-deficient DRG neurons as well as DRG from the FXNI151Fmouse model to study ferroptosis and its regulatory pathways. A lack of frataxin induced upregulation of transferrin receptor 1 and decreased ferritin and mitochondrial iron accumulation, a source of oxidative stress. However, there was impaired activation of NRF2, a key transcription factor involved in the antioxidant response pathway. Decreased total and nuclear NRF2 explains the downregulation of both SLC7A11 (a member of the system Xc, which transports cystine required for glutathione synthesis) and glutathione peroxidase 4, responsible for increased lipid peroxidation, the main markers of ferroptosis. Such dysregulation could be due to the increase in KEAP1 and pGSK3β (Tyr216), which promote cytosolic localization and degradation of NRF2. Moreover, there was a deficiency in the LKB1/AMPK pathway, which would also impair NRF2 activity. AMPK acts as a positive regulator of NRF2 and it is activated by the upstream kinase LKB1. The levels of LKB1 were reduced when frataxin decreased, in agreement with reduced pAMPK (Thr172), the active form of AMPK. SIRT1, a known activator of LKB1, was also reduced when frataxin decreased. In conclusion, this study demonstrated that frataxin deficiency in DRG neurons disrupts iron homeostasis and the intricate regulation of molecular pathways affecting NRF2 activation and the cellular response to oxidative stress, leading to ferroptosis.
The impact of social media-related motivation on fantasy sport users’ playing skills, sense of competition and performance expectancy
Authors: Rai Jaskirat Singh , Cho Heetae , Itani Maher , Singh Amanpreet 
Published: May 2024

PurposeThis study investigated how sources of information across social media platforms influence fantasy users’ sport consumption and enhance their performance expectancy. Specifically, we examined the effects of social media-related motivation on fantasy users’ playing skills, sense of competition and performance expectancy based on the uses and gratifications theory.Design/methodology/approachData were collected from 453 fantasy sport users on social media platforms. We conducted confirmatory factor analysis to assess a measurement model and used serial mediation techniques to examine the relationship between social media-related motivation and fantasy sport users’ performance expectancy.FindingsResults showed that social media-related motivation had significant and positive impacts on fantasy users’ playing skills, sense of competition and performance expectancy. Additionally, we found that fantasy users’ playing skills increased their sense of competition and performance expectancy. A sense of competition was found to positively affect fantasy users’ performance expectancy.Originality/valueThis study provided a valuable contribution to the existing body of knowledge on social media by investigating the influence of social media-related motivation on fantasy sport users. The findings reveal that sharing content-based information on social media platforms plays a vital role in attracting and motivating individuals to engage in fantasy sports. The updated information enhances the playing skills of fantasy users, fosters a sense of competition and improves performance in virtual sport.
Trust region framework-based design of sub-6 GHz m-MIMO antenna and evaluation of SAR
Authors: Turgut Ahmet , Korunur Engiz Begum 
Published: May 2024

Purpose
Currently, massive multiple-input multiple-output (m-MIMO) antennas are typically designed using complex trial-and-error methods. The purpose of this study is to determine an effective optimization method to achieve more efficient antenna design processes.

Design/methodology/approach
This paper presents the design stages of a m-MIMO antenna array compatible with 5G smartphones operating in long term evolution (LTE) bands 42, 43 and 46, based on a specific algorithm. Each antenna element in the designed 10-port m-MIMO antenna array is intended to perfectly cover the three specified LTE bands. The optimization methods used for this purpose include the Nelder–Mead simplex algorithm, covariance matrix adaptation evolution strategy, particle swarm optimization and trust region framework (TRF).

Findings
Among the primary optimization algorithms, the TRF algorithm met the defined objectives most effectively. The achieved antenna efficiency values exceeded 60.81% in the low band and 68.39% in the high band, along with perfect coverage of the desired bands, demonstrating the success of the design with the TRF algorithm. In addition, the potential electromagnetic field exposure caused by the designed m-MIMO antenna array is elaborated upon in detail using computational human models through specific absorption rate analysis.

Originality/value
The comparison of four different algorithms (two local and two global) for use in the design of a 10-element m-MIMO antenna array with a complex structural configuration and the success of the design implemented with the selected algorithm distinguish this study from others.
A catastrophe theory view of accidental dwelling fire injuries
Authors: Taylor Mark , Francis Hulya , Fielding John , Dean Emma 
Published: May 2024

PurposeThe study aims to apply catastrophe theory to the analysis of accidental dwelling fire injuries in terms of age band, gender and contributory factors in order to inform fire prevention activities.Design/methodology/approachThe study employed a case study in a UK Fire and Rescue service concerning analysis of the circumstances of accidental dwelling fire injuries, and the characteristics and behaviours associated with utilising frequency analysis, percentages, ratios and catastrophe theory modelling.FindingsOverall, males were more likely to be injured in an accidental dwelling fire compared to females by a ratio of 1.68 to 1, and those in the age band 50–64 appeared to be at maximum risk. A total of 15.4% of the accidental dwelling fire injuries involved consumption of alcohol or drugs, and 5.9% involved falling asleep.Research limitations/implicationsThe circumstances of accidental dwelling fire injury can be analysed to identify patterns concerning when a catastrophic change relating to ordinary use of domestic objects results in an accidental dwelling fire injury.Practical implicationsA catastrophe theory view can aid the understanding of how ordinary use of domestic objects results in an accidental dwelling fire injury.Social implicationsSince fire injuries have both a social and economic cost, understanding how such fire injuries occur can aid fire prevention through appropriately targeted fire prevention activities.Originality/valueThe study made use of a catastrophe theory view to analyse the circumstances under which accidental dwelling fire injuries occurred using fire injury data from a UK fire and rescue service.
Sustainable recycling management: configuration of risk factors and resilience strategies
Authors: Khan Eijaz Ahmed , Chowdhury Md. Maruf Hossan , Hassan H.M. Kamrul , Mahmud A.K.M. Shakil , Shamsuddoha Mohammad 
Published: May 2024

Purpose
Recycling is associated with positive social and environmental impact, but previous studies have overlooked the cost of recycling operations. Based on the dynamic capability view, the purpose of this study was to identify and evaluate risk factors and resilience strategies within the recycling industry, prioritize these factors and identify the optimal combination of resilience strategies and risk factors to improve market performance.

Design/methodology/approach
The research questions were addressed in three subsequent studies. In Study 1, qualitative interviews were conducted to identify risk factors and strategies to mitigate those risks. In Study 2, quality function deployment methodologies were implemented via case studies derived from three different companies. Based on the results of Studies 1 and 2, in addition to the use of fuzzy set qualitative comparative analysis, Study 3 aimed to determine the optimal combination of risk factors and strategies impacting market performance.

Findings
The results across the three studies revealed a number of risk factors as well as which risk factors and resilience strategies have the greatest impact on market performance. Specifically, it was found that higher levels of readiness, response and recovery strategies lead to greater market performance, whereas weak readiness, response and recovery strategies, along with low societal, environmental and health and safety risk factors, significantly inhibit performance.

Originality/value
This research extends current understandings of market performance in relation to recycling industry management and offers insight for decision-makers toward combating significant risk factors in business-to-business settings.
Anthropomorphised or not? Natural-organic logo’s impact on product value perceptions and consumers’ willingness to pay
Authors: Ho Kenneth Fu Xian , Tarabashkina Liudmila , Liu Fang 
Published: May 2024

Purpose
Building on associative priming, anthropomorphism and biophilia theories, this study aims to explain that a natural–organic (that shows a natural object) and an anthropomorphised natural–organic logo (that shows an anthropomorphised natural object) both act as primes and imbue specific product value perceptions, which subsequently influence willingness to pay a premium price when products have not been used by or are unfamiliar to consumers.

Design/methodology/approach
Two between-subjects experiments were conducted with different products (one with real, but unfamiliar to consumers brand and another with a fictitious brand). Structural equation modelling was used to test the hypotheses.

Findings
Experimental studies showed that natural–organic logos evoked stronger utilitarian (functional and economic) value perceptions, which triggered greater willingness to pay a premium price compared to anthropomorphised natural–organic logos. The effect of hedonic (emotional and novelty) values on willingness to pay a premium price was stronger when an anthropomorphised natural–organic logo was used.

Research limitations/implications
This research offers novel theoretical contributions highlighting the importance of careful logo design to imbue desired value perceptions when products have not been consumed or trialled.

Practical implications
Anthropomorphised natural–organic and natural–organic logos can provide different benefits to brand managers and can be used strategically to form desired value perceptions before products are consumed. Brands that wish to enhance premium pricing via hedonic values should consider using an anthropomorphised natural–organic logo. Natural–organic logos may be more suitable for brands that want to emphasise superior utilitarian values.

Originality/value
To the best of the authors’ knowledge, this research provides the first empirical assessment of the differential effects of the two forms of natural–organic logos on value perceptions and willingness to pay premium price.
How do financial inclusion and bank stability explain agricultural productivity in Sub-Saharan Africa?
Authors: Bekoe Isaac Kofi , Abor Joshua , Sekyi Samuel 
Published: May 2024

PurposeThis study aims to examine the impact of financial inclusion and bank stability on agricultural productivity in Sub-Saharan Africa (SSA).Design/methodology/approachThe study used 38 countries in the SSA with data spanning between 2004 and 2021. The data were analyzed using the two-step system generalized method of moments (GMM) and the panel-corrected standard error (PCSE) model.FindingsThe study found a positive effect of financial inclusion and bank stability on agricultural productivity. The study also discovered that while the access component of financial inclusion has a negative influence on agricultural productivity, the usage dimension has a positive impact.Research limitations/implicationsThe study suggests to policymakers that an inclusive and stable financial system improves agricultural productivity. The findings recommend that policymakers should empower farmers to leverage financial inclusion.Originality/valueThis study provides insightful discussion on the impact of financial inclusion and its various dimensions and bank stability on agricultural productivity in SSA.
The relationship between sustainable HRM practices and employees’ attraction: the influence of SME managers’ values and intentions
Authors: Labelle François , Parent-Lamarche Annick , Koropogui Siba Théodore , Chouchane Rahma 
Published: May 2024

PurposeIn many parts of the world, labor shortages are likely to affect the activities of SMEs. Consequently, SMEs needs to adopt attractive HRM practices. This study analyzes the impact of one type of sustainable HRM (SD-HRM) on employees’ attraction and retention factors such as employees’ motivation, the quality of image and customer satisfaction in SMEs context. It also looks at the impact of SME managers’ value-intentions, calculative (egoist-strategic) and non-calculative (altruist-institutional) on this relationship.Design/methodology/approachDrawing on part of a survey of 409 Quebec SME managers’ commitment to sustainability, a mediation model is used to consider the impact of the manager’s values-intentions on potential workforce attraction and retention factors.FindingsThe results show that the implementation of SD-HRM practices has a positive impact on the outcomes considered, as it was expected, but show the counterintuitive results that it is altruistic values (non-calculative), rather than egoistic values, that helps to maximize the desired effects.Practical implicationsSME managers could adopt SRHRM practices to attract and retain employees. To maximize positive impacts, they might strategically integrate this approach while remaining authentic to their altruistic values. Purely institutional intentions are insufficient. By being both personally committed and strategic, managers can improve both employee well-being and organizational performance.Originality/valueThe original aspect of this research is the integration of expectations of spin-offs (positive or neutral) in relation to SD-HRM, based on the values and intentions of SME managers. This allows to recognize the multiple profiles, justifications and objectives of SMEs, which do not form a monolithic whole and need to be understood and supported by considering their differences.
Erythropoietin hyporesponsiveness in non‐alcoholic fatty liver disease
Authors: Zou Huixi , Wong Raymond S. M. , Yan Xiaoyu 
Published: May 2024

AbstractTreatment with erythropoietin (EPO) can correct anaemia in chronic kidney disease (CKD) patients; however, up to 10% exhibit resistance or hyporesponsiveness to EPO. Non‐alcoholic fatty liver disease (NAFLD), prevalent liver disease in CKD patients, may limit EPO response because of thrombopoietin deficiency, iron homeostasis disorder and inflammation. Therefore, we hypothesized NAFLD is a risk factor for EPO responsiveness. To test our hypothesis, we evaluated the effect of EPO in healthy rats and rats with NAFLD induced by a high‐fat, high‐carbohydrate (HFHC) diet. After 12 weeks on the HFHC diet, NAFLD rats showed lower erythroid response to EPO treatment than healthy rats. We, then, determined that the primary cause of EPO hyporesponsiveness could be iron deficiency associated with inflammation, which reduces erythroid cell production. Specifically, the concentrations of hepcidin, ferritin, transferrin and white blood cells in NAFLD rats were 12.8‐, 16.4‐, 2.51‐ and 1.40‐fold higher than those in healthy rats, respectively. However, erythroid cell types in the bone marrow of NAFLD rats were significantly reduced. In conclusion, our data suggest that NAFLD could be a risk factor for EPO responsiveness, which is attributed to functional iron deficiency associated with inflammation.
Politicians' high‐status signals make less‐educated citizens more supportive of aggression against government: A video‐vignette survey experiment
Authors: Noordzij Kjell , de Koster Willem , van der Waal Jeroen 
Published: May 2024

AbstractVarious branches of the literature suggest that exposure to the high‐status appearances and lifestyles of politicians in contemporary “diploma democracies” affects the attitudes and behavior of less‐educated citizens because it confronts them with their lower status in the political domain. Informed by this, we theorize that such exposure inspires docility (a lower subjective social status, weaker feelings of political entitlement) and revolt (anger, more support for aggression against government). To investigate this, we conducted an original, pre‐registered, video‐vignette survey experiment among a representative sample of the Dutch population. While our findings likely generalize to other liberal democracies, the Dutch context is suitable to test our theorizing because low‐status and high‐status appearances and lifestyles are found across the political arena, irrespective of politicians' substantive positions or use of populist rhetoric. Each less‐educated respondent (n = 1390) was presented with a professionally produced video of an actor playing the part of a fictitious politician. This politician signaled either a low or a high status via his appearance and lifestyle. The potentially confounding factors of his substantive positions and populist rhetoric were randomized and controlled for. We find that exposure to the high‐status politician increased less‐educated citizens' support for aggression against the government. Through exploratory analyses, we assess how the responses of docility and revolt are interrelated, and how they are shaped by less‐educated citizens' economic status.
Continuous production machine for separating and shaping Taiping Houkui tea
Authors: Wu Zhengmin , Zhong Hua , Wang Xiaoran , Sun Changying , Wang Yujie , Luo Kun , Qin Kuan 
Published: May 2024

AbstractIn response to the challenges of low automation and a lack of a continuous processing system for Taiping Houkui tea, this study proposed a design scheme for a continuous processing line and built a continuous processing prototype for testing by combining the production requirements of Taiping Houkui tea, the characteristics of withered leaves, and the existing relevant production equipment. First, the physical properties of Taiping Houkui tea were determined. A simulation was performed using the Hertz–Mindlin model, and the motion states of the tea leaves were obtained under different conditions to define the parameter design range of the experimental platform and verify its structural rationality. Then, the response surface methodology was used to optimize the working parameter ranges and obtain the best working parameters for the feeding and kneading mechanisms. Finally, a continuous production prototype was constructed for further production verification. The experimental results show that the success rate of continuous production on this platform was 70.68%, with an average output of approximately 0.4 kg/h for Taiping Houkui dry tea on a single slide track, and the produced tea was similar to manually made tea. This demonstrates that the continuous production technique has high feasibility and provides a reference for continuous production of Taiping Houkui tea.
Feeding strategy and feed protein level affect the gut microbiota of common carp (Cyprinus carpio)
Authors: Mes Wouter , Lücker Sebastian , Jetten Mike S. M. , Siepel Henk , Gorissen Marnix , van Kessel Maartje A. H. J. 
Published: May 2024

AbstractCommon carp (Cyprinus carpio) were fed food with different protein concentrations following different feeding regimes, which were previously shown to affect growth, nitrogen excretion and amino acid catabolism. 16S rRNA gene amplicon sequencing was performed to investigate the gut microbiota of these fish. Lower dietary protein content increased microbial richness, while the combination of demand feeding and dietary protein content affected the composition of the gut microbiota. Hepatic glutamate dehydrogenase (GDH) activity was correlated to the composition of the gut microbiota in all dietary treatments. We found that demand‐fed carp fed a diet containing 39% protein had a significantly higher abundance of Beijerinckiaceae compared to other dietary groups. Network analysis identified this family and two Rhizobiales families as hubs in the microbial association network. In demand‐fed carp, the microbial association network had significantly fewer connections than in batch‐fed carp. In contrast to the large effects of the feeding regime and protein content of the food on growth and nitrogen metabolism, it had only limited effects on gut microbiota composition. However, correlations between gut microbiota composition and liver GDH activity showed that host physiology and gut microbiota are connected, which warrants functional studies into the role of the gut microbiota in fish physiology.
German teachers' pilgrimage to an Israeli Holocaust Memorial: Emotions, encounters, and contested visions
Authors: Levenson Lance , Lorenz‐Sinai Friederike , Kessl Fabian , Resnik Julia 
Published: May 2024

AbstractDrawing on anthropological conceptions of pilgrimage, our ethnography of professional development at an Israeli Holocaust Memorial follows German teachers on journeys to Israel. Seeking transformative and transferable experiences to combat anti‐Semitism in schools, teachers experienced the voyage as a secular pilgrimage rooted in Christian traditions of guilt, confession, and absolution. As teachers' emotional encounters in Israel simultaneously forged communitas and challenged official historical–pedagogical visions, their practices abroad elucidate prevalent Holocaust education discourses in contemporary Germany.