bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dos und Don’ts in der Produktionslogistik
Authors: Wenzel Alexander , Welzel Kira , Nyhuis Peter 
Published: May 2024

Abstract
Neben den Produkteigenschaften Preis und Qualität stellt die Realisierung einer hohen logistischen Leistungsfähigkeit für produzierende Unternehmen eine der wichtigsten Aufgaben dar, um sich von der Konkurrenz abzuheben. Hier ergibt sich für die Unternehmen jedoch die Herausforderung, sich bei einer steigenden Komplexität der Lieferketten im Spannungsfeld zwischen einer hohen Logistikleistung und geringen Logistikkosten zu positionieren. Dabei passieren zum Teil vermeidbare Fehler, die u.a. auf unzureichendem Wissen über wichtige Wirkzusammenhänge in der Produktionslogistik bei Entscheidungsträgern zurückzuführen sind. Dieser Beitrag präsentiert logistische Entscheidungsgrundsätze (Dos und Don’ts) zur Vermeidung der Fehler und zur Verbesserung der Logistikleistung mit dem Fokus auf eine termingerechte Produktion.
FEM-Simulationen von Schmiedeprozessen mit inhomogener Erwärmung
Authors: Jagodzinski Arne , Kriwall Mareile , Stonis Malte , Behrens Bernd-Arno 
Published: May 2024

Abstract
Durch eine inhomogene Rohteilerwärmung kann ein Umformprozess materialeffizienter gestaltet werden. Die vorliegende Studie befasst sich mit der Erstellung eines FEM-Simulationsmodells zur Auslegung von Warmmassivumformprozessen mit einer inhomogenen Rohteilerwärmung. Die durchgeführten Simulationen werden mit experimentell durchgeführten Schmiedeversuchen verglichen, um die Genauigkeit des Modells zu ermitteln. Mit dem erstellten Simulationsmodell ist es möglich die Machbarkeit von Schmiedeprozessen mit einer inhomogenen Erwärmung zu Überprüfen.
Reproductive Ageing: Metabolic contribution to age-related chromosome missegregation in mammalian oocytes
Authors: Mihalas Bettina P , Marston Adele L , Wu Lindsay E , Gilchrist Robert B 
Published: May 2024

In brief
Chromosome missegregation and declining energy metabolism are considered to be unrelated features of oocyte ageing that contribute to poor reproductive outcomes. Given the bioenergetic cost of chromosome segregation, we propose here that altered energy metabolism during ageing may be an underlying cause of age-related chromosome missegregation and aneuploidy.

Abstract
Advanced reproductive age in women is a major cause of infertility, miscarriage and congenital abnormalities. This is principally caused by a decrease in oocyte quality and developmental competence with age. Oocyte ageing is characterised by an increase in chromosome missegregation and aneuploidy. However, the underlying mechanisms of age-related aneuploidy have not been fully elucidated and are still under active investigation. In addition to chromosome missegregation, oocyte ageing is also accompanied by metabolic dysfunction. In this review, we integrate old and new perspectives on oocyte ageing, chromosome segregation and metabolism in mammalian oocytes and make direct links between these processes. We consider age-related alterations to chromosome segregation machinery, including the loss of cohesion, microtubule stability and the integrity of the spindle assembly checkpoint. We focus on how metabolic dysfunction in the ageing oocyte disrupts chromosome segregation machinery to contribute to and exacerbate age-related aneuploidy. More specifically, we discuss how mitochondrial function, ATP production and the generation of free radicals are altered during ageing. We also explore recent developments in oocyte metabolic ageing, including altered redox reactions (NAD+ metabolism) and the interactions between oocytes and their somatic nurse cells. Throughout the review, we integrate the mechanisms by which changes in oocyte metabolism influence age-related chromosome missegregation.
Exploring noise-induced techniques to strengthen deep learning model resilience
Authors: Ganie Aadil Gani , Dadvadipour Samad 
Published: May 2024

AbstractIn artificial intelligence, combating overfitting and enhancing model generalization is crucial. This research explores innovative noise-induced regularization techniques, focusing on natural language processing tasks. Inspired by gradient noise and Dropout, this study investigates the interplay between controlled noise, model complexity, and overfitting prevention. Utilizing long short-term memory and bidirectional long short term memory architectures, this study examines the impact of noise-induced regularization on robustness to noisy input data. Through extensive experimentation, this study shows that introducing controlled noise improves model generalization, especially in language understanding. This contributes to the theoretical understanding of noise-induced regularization, advancing reliable and adaptable artificial intelligence systems for natural language processing.
Sociodemographic factors associated with vaccine hesitancy in the South Asian community in Canada
Authors: Manoharan Baanu , Stennett Rosain , de Souza Russell J. , Bangdiwala Shrikant I. , Desai Dipika , Kandasamy Sujane , Khan Farah , Khan Zainab , Lear Scott A. , Loh Lawrence , Nocos Rochelle , Schulze Karleen M. , Wahi Gita , Anand Sonia S. 
Published: May 2024

Abstract
Objective
South Asians represent the largest non-white ethnic group in Canada and were disproportionately impacted by the COVID-19 pandemic. We sought to determine the factors associated with vaccine hesitancy in South Asian Canadians.

Methods
We conducted a cross-sectional analysis of vaccine hesitancy using data collected at the baseline assessment of a prospective cohort study, COVID CommUNITY South Asian. Participants (18 + years) were recruited from the Greater Toronto and Hamilton Area in Ontario (ON) and the Greater Vancouver Area in British Columbia (BC) between April and November 2021. Demographic characteristics and vaccine attitudes measured by the Vaccine Attitudes Examination (VAX) scale were collected. Each item is scored on a 6-point Likert scale, and higher scores reflect greater hesitancy. A multivariable linear mixed effects model was used to identify sociodemographic factors associated with vaccine hesitancy, adjusting for multiple covariates.

Results
A total of 1496 self-identified South Asians (52% female) were analyzed (mean age = 38.5 years; standard deviation (SD): 15.3). The mean VAX score was 3.2, SD: 0.8 [range: 1.0‒6.0]. Factors associated with vaccine hesitancy included: time since immigration (p = 0.04), previous COVID-19 infection (p < 0.001), marital status (p < 0.001), living in a multigenerational household (p = 0.03), age (p = 0.02), education (p < 0.001), and employment status (p = 0.001).

Conclusion
Among South Asians living in ON and BC, time since immigration, prior COVID-19 infection, marital status, living in a multigenerational household, age, education, and employment status were associated with vaccine hesitancy. This information can be used to address vaccine hesitancy in the South Asian population in future COVID-19 waves or pandemics.
A Corpus-based Analysis of Rhetorical Moves and P-frames in an Omani Learner Corpus of Research Project Abstracts
Authors: Mathew Priya , Mccallum Lee 
Published: May 2024

Background: Rhetorical moves have long been studied in several disciplinary texts, including research articles and their part-genres. A solid base of literature has emerged in this respect, informing current writing pedagogy for novice writers. However, one part-genre which has been rarely studied is student project abstracts. This paper represents one of the first studies to explore the extent rhetorical moves are realised through the linguistic unit of phrase frames (p-frames) in final year Capstone project abstracts.
Methods: Using two faculty-informed analytical frameworks, the paper explores the use of rhetorical moves and p-frames in corpora of Social and Physical Science student abstracts. The moves and the p-frames (if any) used to realise them were identified in order to understand how students organised this part-genre and to gauge their formulaicity.
Results: Amongst the key findings was that Omani students did not perform all the rhetorical moves recommended by the faculty. Moreover, they added spontaneous moves of their own to the abstracts. When performing rhetorical moves, they used very few p-frames, indicating that their approach did not rely on formulaic language of this nature.
Conclusions: Pedagogical implications for the Omani context and for broader EAP contexts are discussed.
Mechanisms for Microseismicity Occurrence Due to CO2 Injection at Decatur, Illinois: A Coupled Multiphase Flow and Geomechanics Perspective
Authors: Silva Josimar A. , Khosravi Mansour , Yoon Hongkyu , Fehler Michael , Frailey Scott , Juanes Ruben 
Published: May 2024

ABSTRACT
We numerically investigate the mechanisms that resulted in induced seismicity occurrence associated with CO2 injection at the Illinois Basin–Decatur Project (IBDP). We build a geologically consistent model that honors key stratigraphic horizons and 3D fault surfaces interpreted using surface seismic data and microseismicity locations. We populate our model with reservoir and geomechanical properties estimated using well-log and core data. We then performed coupled multiphase flow and geomechanics modeling to investigate the impact of CO2 injection on fault stability using the Coulomb failure criteria. We calibrate our flow model using measured reservoir pressure during the CO2 injection phase. Our model results show that pore-pressure diffusion along faults connecting the injection interval to the basement is essential to explain the destabilization of the regions where microseismicity occurred, and that poroelastic stresses alone would result in stabilization of those regions. Slip tendency analysis indicates that, due to their orientations with respect to the maximum horizontal stress direction, the faults where the microseismicity occurred were very close to failure prior to injection. These model results highlight the importance of accurate subsurface fault characterization for CO2 sequestration operations.
Retailers’ Compliance with Federal Age of Cigarette Sales Policies – Pitt County, North Carolina, January–March 2022
Authors: Lee Joseph G. L. , Sesay Mahdi , van de Venne Judy , Kong Amanda Y. , Hrywna Mary , Rose Shyanika W. , Delnevo Cristine D. 
Published: May 2024

Background Tobacco use remains a leading cause of preventable morbidity and premature mortality. In December 2019, the federal age of sale for tobacco products increased from age 18 to age 21. This study aimed to evaluate the implementation of federal Tobacco 21 policies in Pitt County, North Carolina, by conducting multiple purchase attempts for cigarettes. Methods Stores in Pitt County that sold cigarettes were randomly sampled and visited by up to six different underage buyers (aged 18–20 years) who attempted to buy cigarettes from January to March 2022. Buyers made a total of 217 cigarette purchase attempts from 49 Pitt County retailers. Analyses were conducted using SPSS Complex Samples (v.28/Macintosh) to estimate retailer prevalence of requesting identification (ID) and selling to underage buyers across multiple purchase attempts. Results On average, retailers failed to request ID in 15.4% of purchase attempts (95% CI; 9.4%–21.3%) and sold to an underage buyer 34.2% of the time (95% CI; 27.0%–41.4%). Additionally, 75.5% (95% CI; 63.4%–84.6%) of retailers sold to an underage buyer at least once. Limitations This study is limited to a single county in North Carolina and to underage buyers aged 18 to 20 years. Conclusions There is widespread noncompliance with federal age-of-sale policies for tobacco products in Pitt County, North Carolina. State enforcement is warranted, and North Carolina’s youth access law should be amended to match the federal age of sale. Changes to the law should allow research involving underage purchases.
Psychiatric Residential Treatment Facilities for Child Behavioral Health Services in North Carolina Medicaid
Authors: Lanier Paul , Rose Roderick , Gibbs Daniel , Hyman Jacob , Kamdar Neil , Konstanzer Joseph , Hassmiller Lich Kristen 
Published: May 2024

Background Psychiatric residential treatment facilities (PRTFs) are non-hospital inpatient treatment settings for children with severe be­havioral health disorders. PRTFs are a restrictive and costly form of care that can potentially be avoided with community-based behavioral health services. Methods Statewide Medicaid enrollment and claims data for 2015–2022 were used to describe PRTF utilization in North Carolina. We examined annual episodes of care in PRTFs and compared trends before and during the COVID-19 public health emergency. Results From 2015 to 2022, 10,038 children insured by NC Medicaid entered a PRTF across 10,966 episodes of care. In the past five years (2018–2022), care in PRTFs resulted in Medicaid expenditures of over $550 million total, or over $100 million per year. In 2022, 42% of children who entered PRTFs were in foster care and 44% of children were placed in PRTFs outside of North Carolina. Limitations The analysis was limited to data collected for administrative purposes. Conclusions Current trends indicate an ongoing overrepresentation of children in foster care placed in PRTFs and increased out-of-state PRTF placements. Coordinated efforts in future research, policy, and practice are needed to determine the cause of these trends and iden­tify solutions.
Factors Associated with Substance Use Disorder among High-Need Adolescents and Young Adults in North Carolina
Authors: Hughes Phillip M. , Annis Izabela E. , deJong Neal A. , Christian Robert B. , Davis Scott A. , Thomas Kathleen C. 
Published: May 2024

Background Prevalence of substance use disorders (SUD) is high among adolescents and young adults (AYAs) with complex medical needs. Little is known about risk factors for SUD in this population. Methods This retrospective cohort study used electronic health record data from a large academic hospital system (2015–2019) to identify adolescents (aged 10–17) and young adults (aged 18–27) with intellectual/developmental disorders, psychiatric conditions, or complex medical conditions. Logistic regression was used to identify demographic, clinical, and neighborhood-level risk factors associated with SUD in this population. Results A total of 149 adolescents and 536 young adults had a SUD diagnosis (6.7% and 20.6%, respectively). Among adolescents, notable risk factors for SUD included age (adjusted odds ratio [aOR] = 1.42, 95% confidence interval [CI] = [1.31, 1.54]), Hispanic ethnicity (aOR = 2.10, 95% CI = [1.10, 3.99]), additional psychoactive medication classes (aOR = 1.27, 95% CI = [1.11, 1.46]), and living in a “high” child opportunity index (COI) (aOR = 2.06, 95% CI [1.02, 4.14]) or a “very high” COI (aOR = 3.04, 95% CI [1.56,5.95]) area. Among young adults, notable risk factors included being male (aOR = 2.41, 95% CI [1.91, 3.05]), being Black (aOR = 1.64, 95% CI [1.28, 2.09]), and additional non-psychoactive (aOR = 1.07, 95% CI [1.03, 1.11]) or psychoactive medication classes (aOR = 1.17, 95% CI [1.07, 1.28]). Limitations These descriptive analyses are limited to one large academic hospital system in North Carolina and may not be representative of all high-need AYAs in the state. Conclusions Several demographic, clinical, and neighborhood risk factors are associated with SUD in high-need AYAs.
Developing IPEC Competencies for an Evolving Professional Landscape: Q&A with Jeffery Stewart, DDS
Authors: Zomorodi Meg 
Published: May 2024

Jeffery Stewart, DDS, MS, a consultant to the American Dental Education Association, met with Meg Zomorodi, PhD, RN, ANEF, FAAN, of UNC-Chapel Hill, to discuss the latest revisions to the IPEC Core Competencies for Interprofessional Collaborative Practice. Released in November 2023, these updated competencies build on previous versions from 2011 and 2016 to incorporate the perspectives of seven new IPEC member organizations and reflect the continuously evolving research, policy, education, and practice landscape.
Assessing Interprofessional Collaboration at Clinical Learning Sites: Methodology on Developing the IP-CLEAR Tool
Authors: Sanders Kimberly A. , Lynn Mary R. 
Published: May 2024

Interprofessional Clinical Learning Environment Assessment and Reflection (IP-CLEAR) tool was developed by a team of faculty from the schools of nursing, pharmacy, and medicine at University of North Carolina at Chapel Hill (UNC-CH), with the support of the North Carolina Area Health Education Consortium (NC AHEC) and the UNC-CH Office of Interprofessional Education and Practice (IPEP). The IP-CLEAR tool is intended for use by clinical sites that have or want to have clinical learners engaged and integrated into an excellent interprofessional CLE. The development of the IP-CLEAR and projections for future work are described here.
“It Takes a Village”- A Conversation with the Interprofessional Diabetes Clinic at the ECU Health Family Medicine Center
Authors: Lysaght Christine , Messenger Jamie , Patil Shiv , Craven Kay 
Published: May 2024

Interprofessional collaboration and shared understanding positively impact both patients and providers. Current recommendations from the CDC and experts agree that collaboration between diverse professions is necessary to improve patient outcomes and empower patients to selfmanage their chronic conditions.
Early identification of thyroid illness and its intricate relationship to renal function may be crucial for therapy planning
Authors: Pavithra SS , Hegde Y Siddarth , Shetty Kaushal 
Published: May 2024

An epidemiological shift has occurred in India, where the burden of chronic illnesses is increasing, and communicable diseases are declining. Chronic diseases such as diabetes mellitus, cancer, and chronic respiratory disorders are on the rise, and this trend has been attributed to unhealthy lifestyles, increased urbanization, and changes in society and the environment. Such a category did not include chronic kidney disease (CKD). End-stage renal disease (ESRD) is defined as glomerular filtration rate (GFR) &#60;15 ml/min/1.73 m2, while chronic kidney disease (CKD) is defined as a sustained eGFR of &#60;60 ml per minute per 1.73 m2 of body-surface area for more than three months irrespective of the underlying cause while glomerular filtration rate (GFR) &#60;15 ml/min/1.73 m2 is considered as end-stage renal disease (ESRD). CKD is classified into five stages ranging from mild dysfunction to complete failure. Globally, CKD is a significant cause of morbidity and death and there is a 38% increase in mortality linked to renal failure in developing nations like India. It has been shown that the epidemiology of CKD in India differs from that in the West; patients in India were, on average, five to twenty years younger Pregnancy-related malnutrition, environmental variables, genetics, or postponed medical care that accelerates the course of CKD are among the likely reasons and birth weight.The present hospital-based, cross-sectional, observational study was conducted in the a tertiary care teaching hospital in South India from December 2020 to January 2024. The study comprised 50 patients of CKD between 30 and 70 years of age of both sexes with no previous history of any thyroid dysfunction, while 50 apparently healthy age and sex-matched individuals from the same ethnic population with normal renal function and no past history of thyroid disorders served as a control group.The results of this study and most others, there is a possibility that abnormal thyroid hormone activity may result in a decline in renal function. Early identification of thyroid illness and its intricate relationship to renal function may be crucial for therapy planning.The current cross-sectional hospital-based observational study discovered that uremic patients had considerably lower mean TT3 and TT4 and higher mean TSH when compared to healthy controls, regardless of the kind of medication or duration of the disease. Based on the results of this study and most others, there is a possibility that abnormal thyroid hormone activity may result in a decline in renal function. Early identification of thyroid illness and its intricate relationship to renal function may be crucial for therapy planning.
Isocucurbitacin B inhibits glioma growth through PI3K/AKT pathways and increases glioma sensitivity to TMZ by inhibiting hsa-mir-1286a
Authors: Han Mingyu , An Junsha , Li Sui , Fan Huali , Wang Li , Du Qing , Du Junrong , Yang Yuxin , Song Yuqin , Peng Fu 
Published: May 2024

Aim: Glioma accounts for 81% of all cancers of the nervous system cancers and presents one of the most drug-resistant malignancies, resulting in a relatively high mortality rate. Despite extensive efforts, the complete treatment options for glioma remain elusive. The effect of isocucurbitacin B (isocuB), a natural compound extracted from melon pedicels, on glioma has not been investigated. This study aims to investigate the inhibitory effect of isocuB on glioma and elucidate its underlying mechanisms, with the objective of developing it as a potential therapeutic agent for glioma.
Methods: We used network pharmacology and bioinformatics analysis to predict potential targets and associated pathways of isocuB in glioma. Subsequently, the inhibitory effect of isocuB on glioma and its related mechanisms were assessed through Counting Kit-8 (CCK-8), wound healing, transwell, Western blot (WB), reverse transcription-quantitative polymerase chain reaction (RT-qPCR), and other in vitro experiments, alongside tumor formation experiments in nude mice.
Results: Based on this investigation, it suggested that isocuB might inhibit the growth of gliomas through the PI3K-AKT and MAPK pathways. Additionally, we proposed that isocuB may enhance glioma drug sensitivity to temozolomide (TMZ) via modulation of hsa-mir-1286a. The CCK-8 assay revealed that isocuB exhibited inhibitory effects on U251 and U87 proliferation and outperformed TMZ. Wound healing and transwell experiments showed that isocuB inhibited the invasion and migration of U251 cells by suppressing the activity of MMP-2/9, N-cadherin, and Vimentin. The tunnel and flow cytometry (FCM) assays revealed that isocuB induced cell apoptosis through inhibition of BCL-2. Subsequently, we conducted RT-qPCR and Western blot (WB) experiments, which revealed that PI3K/AKT and MAPK pathways might be involved in the mechanism of the inhibition isocuB on glioma. Additionally, isocuB promoted the sensitivity of glioma U251 to TMZ by inhibiting hsa-mir-1286a. Furthermore, we constructed TMZ-resistant U251 strains and demonstrated effective inhibition by isocuB against these resistant strains. Finally, we confirmed that isocuB can inhibit tumor growth in vivo through experiments on tumors in nude mice.
Conclusion: IsocuB may protect against glioma by acting on the PI3K/AKT and MAPK pathways and promote the sensitivity of glioma U251 to TMZ by inhibiting hsa-mir-1286a.