bluuebunny/crossref_metadata_2025_split huggingface dataset:
EFFICIENCY OF FEED ADDITIVE EIMERIX ® FOR NATURAL INFECTION OF BROILER CHICKENS WITH EIMERIA SPP.
Authors: Stetsko T. I. , Perig Zh. M. , Padovsky V. N. , Balyan O. Z. 
Published: May 2024

The article presents the results of the study of the effectiveness of the feed additive EIMERIX® (powder for oral use, granulated), produced by JSC Biopharm (Ukraine), the active pharmaceutical ingredient of which is the polyester ionophore antibiotic monensin, when used for broiler chickens naturally infected with coccidia of the genus Eimeria.
The study was conducted on 17-day-old broiler chickens with clinical signs of coccidiosis. E. tenella and E. maxima were identified from faeces samples of sick broiler chickens. For three weeks (21 days), the sick bird the feed supplement EIMERIX® was added in feed at a dose of 0.5 g per 1 kg of feed, or 100 mg of sodium monensin per 1 kg of feed (experimental group). The control group consisted of broiler chickens suffering from coccidiosis, which were not given the supplement or any other anticoccidial drugs.
The main criteria for demonstrating the estimation of the feed additive EIMERIX® were: the number of Eimeria oocysts in feces; mortality and morbidity of poultry associated with coccidiosis. Additional indicators of the effectiveness of the feed additive were: average live weight; average daily increase in live weight of poultry; average daily feed consumption, the ratio of the amount of feed consumed to growth; data of bird health monitoring during the experiment.
On the 21st day of the experiment, the excretion of Eimeria oocysts in the feces of broiler chickens with coccidiosis practically stopped (<100 oocysts/g of feces), what was confirmed by the absence of clinical signs of coccidiosis in the birds. Addition of EIMERIX® additive in feed contributed for the reduction of morbidity and mortality among sick birds. More live weight gains and lower feed conversion ratios were observed in Eimeria disease birds treated with a feed additive versus untreated birds.
The results of the study showed that the use of EIMERIX® feed additive for broiler chickens with coccidiosis, in the recommended by the manufacturer dosage, causes a decrease of the eimeria infection degree of the bird, reduces its morbidity and mortality, and also contributes to an increase of average daily gains and improvement of feed conversion.
DEVELOPMENT AND IMPLEMENTATION OF UPLC-MS/MS METHOD FOR THE DETERMINATION OF PIPERAZINE RESIDUES IN PIG TISSUES
Authors: Yanovych D. , Rydchuk M. , Plotytsia S. , Zasadna Z. , Tataryn T. , Kislova S. , Pazderska O. , Korol N. 
Published: May 2024

The manuscript presents the results of the development and validation of UPLC-MS/MS method for the determination of piperazine residues in muscle and parenchymal tissues of pigs. Piperazine and its derivatives are well-known anthelmintic drugs used in human and veterinary medicine. Piperazine is a heterocyclic compound without any chromophore groups with a low molecular weight (86.1 g/mol), which makes its detection in biological samples by LC-MS/MS difficult. We have developed the confirmatory technique for the direct UPLC-MS/MS assay of piperazine residues (without prior derivatization) in animal tissues after sample purification using solid-phase extraction. The proposed sample preparation includes homogenization, liquid-liquid extraction using acetonitrile, concentration and purification of samples from matrix components using SPE cartridges Oasis HLB (Waters) and with additional concentration of the eluate by drying. The analysis of the prepared samples was carried out by the method of ultra high performance liquid chromatography with tandem mass spectrometric detection using the precursor ion of 87.0 m/z and product ions of 43.9 and 70.0 m/z (ES+ ionization, multiple reactions monitoring mode).
In order to experimentally confirm the fitting-for-purpose of the developed confirmatory method for clinical studies of veterinary drugs based on API piperazine and to assess the safety of food products of animal origin for piperazine residues, the validation of the developed UPLC-MS/MS method for the determination of piperazine in muscle tissues and liver of pigs was carried out using approaches described in EMEA/CVMP/VICH/463202/2009 and in accordance with Regulation (EU) 2021/808. In the process of UPLC-MS/MS technique validation, various key operating parameters were established for both investigated matrices: limit of detection, limit of quantification, linearity, specificity, accuracy, trueness. In particular, it was established that the developed method provides determination of piperazine residues in muscle tissues and liver of pigs with a sensitivity of 50 and 400 μg/kg, respectively.The developed and validated confirmatory UPLC-MS/MS method for the determination of residual amounts of piperazine is highly sensitive, highly selective and rapid, appropriate for the control and monitoring of the safety of animal meat and liver samples, as well as to provide analytical support for clinical studies of veterinary drugs based on API piperazine and its derivatives.
Fighting corruption: A theoretical articulation of the themes of social responsibility, corporate governance, and agency theory
Authors: Machado Mônica Cristina Rovaris , Santos Ruan Carlos dos 
Published: May 2024

Objective: Corruption, seen as the abuse or misuse of power or trust for one's benefit instead of the purpose for which that power or trust was granted, has caused problems for many countries and the principles of Social Responsibility through the models of Carroll and Schwartz and Corporate Governance (have been pointed out in the literature as a mitigating agent of this problem. On the other hand, other research indicates the need to be cautious when guided by the mentality of the Agency Theory, which defends it as a neutral and sufficient instrument to mitigate corruption problems.
Method: This study consists of a theoretical essay based on a bibliographical survey that exposes the themes of Corruption, Social Responsibility, Corporate Governance, and Agency Theory. It surveys the different definitions, lines of research, lines of thought, supporting theories, dualities, and conflicts around the mainstream.
Results: The study's justification is centered on the perception that while studies have empirically tested the relationship between corruption and countries' accounting environments, only some have dedicated themselves to critically reflecting on the knowledge produced about this relationship.
Originality/Relevance: In the context presented, a good governance structure is recommended for effective administration and management in anti-corruption bodies. The principles of Corporate Governance and Social Responsibility, which are Transparency (disclosure), Accountability, and Fairness, align with the principles of Agency Theory, which are mainly related to ethics and morality in interpersonal relationships in organizations.
Theoretical/methodological contributions: This contribution is intended to reflect on the need for organizations to contribute to the fight against corruption in their relations and to the realization of a socially responsible administration through Corporate Governance and Agency Theory, with consonance between the objectives of shareholders and agents in an intermittent fight against corruption.
Autistic traits specific to communication ability are associated with performance on a Mooney face detection task
Authors: English Michael C. W. , Maybery Murray T. , Visser Troy A. W. 
Published: May 2024

AbstractDifficulties in global face processing have been associated with autism. However, autism is heterogenous, and it is not known which dimensions of autistic traits are implicated in face-processing difficulties. To address this gap in knowledge, we conducted two experiments to examine how identification of Mooney face stimuli (stylized, black-and-white images of faces without details) related to the six subscales of the Comprehensive Autistic Trait Inventory in young adults. In Experiment 1, regression analyses indicated that participants with poorer communication skills had lower task sensitivity when discriminating between face-present and face-absent images, whilst other autistic traits had no unique predictive value. Experiment 2 replicated these findings and additionally showed that autistic traits were linked to a reduced face inversion effect. Taken together, these results indicate autistic traits, especially communication difficulties, are associated with reduced configural processing of face stimuli. It follows that both reduced sensitivity for identifying upright faces amongst similar-looking distractors and reduced susceptibility to face inversion effects may be linked to relatively decreased reliance on configural processing of faces in autism. This study also reinforces the need to consider the different facets of autism independently.
The Effect Of Market Value Ratio And Activity Ratio On Financial Distress In Technology Sector Companies Listed On The Idx 2021 - 2023
Authors: Nofita Cintya Nindy , Darmansyah Asep 
Published: May 2024

Technological developments in Indonesia have encouraged the growth of the technology sector, however the tech winter phenomenon in 2022 caused a decline in investor interest, resulting in funding difficulties and potential financial distress for technology companies. This can be seen from the significant decline in the ROA profitability ratio. The decline in ROA indicates that technology companies are increasingly inefficient in managing assets to generate net profits. This condition has certainly received attention and the author wants to evaluate it in depth to prevent more severe negative impacts in the future. The aim of this research is to examine the influence of Earning Per Share (EPS), Price Book Value (PBV), Total Asset Turnover (TATO), and Fixed Asset Turnover (FATO) on predicting financial distress using the Altman Z-Score model in sector companies technology listed on the Indonesia Stock Exchange (IDX) for the period 2021Q1 to 2023Q2. This research uses 13 samples of technology sector companies listed on the IDX with a study period of 3 years. The company's financial data was analyzed using panel data regression analysis techniques to determine the influence of the independent variables on the dependent variable. The results of this study show that TATO is partially significant and has a positive effect on financial distress. EPS, PBV, FATO are partially not significant effect on financial distress. For EPS, PBV, TATO, FATO simultaneously have a significant effect on financial distress in technology sector companies. The findings of this research are expected to provide valuable insights for investors, creditors and other stakeholders in assessing the financial risks of technology companies and help them reduce the risk of losses
Impact of Climate Change on Agriculture & Vice Versa: A Review
Authors: Majeed Najma , Sharif Rimsha , Sheeraz Muhammad Noman , Sajjad Sabeen , Maqsood Hafsa , Imran Muhammad , Jamshaid Muhammad Usman , Arif Muhammad , Hussain Muhammad Baqir 
Published: May 2024

The article tackles the intricate relationship between agriculture and climate change, shedding light on the sector's vulnerability to the issue and its significant contribution to it. It not only underlines the simultaneity of the problem of climate change adaptation in agriculture but also highlight the need of greenhouse gas reductions. Climate change disrupts agricultural practices through extreme weather events like droughts, flood and unpredictable rainfall patterns. Climate changes threaten agricultural output and food security, economic hardship and social unrest. Climate change isolates crops production hence resulting in low yields, economic losses, and changing food prices. Cattle, rice growth, fertilizer use and residue burning are principal greenhouse gas contributors of agriculture. When carving virgin forests for agricultural purposes, the ancient carbon is released and climatic patterns are disrupted, greatly exacerbating the problem. These agricultural practices include deforestation, utilization of fossil fuel, and intensive use of water. Mitigation in climate change require sustainable agricultural practices that reduced emission and improve soil health. We need to adapt agricultural practices to be more resilient in the face of climate change while also reducing agricultures contribution to the problem. The complex interplay between climate change and agriculture requires a holistic approach that integrates mitigation and adaptation strategies at local, national and global scale. Efforts to enhance resilience, promote sustainable practices and support equitable adaptation measures are essential to safeguarding the future of agriculture in a changing climate
Endovascular Therapy in Large Core Ischemic Strokes: Real-World Indian Experience
Authors: Garg Surabhi , Ramachandran Dileep , Mishra Tanaya , Rangarajan Anush , Dash Gopal Krishna , Manohar Radhika , Philip Vivek Jacob , Shetty Kuldeep , Thomas Pravin , Krishna Shri Harsha , Nalubolu Shivakanth , Huded Vikram 
Published: May 2024

Background:
Large core acute ischemic strokes have predominantly been excluded from endovascular therapy (EVT) studies due to perceived higher risks of hemorrhage and poorer functional outcomes. However, recent randomized controlled trials (RCTs) indicate that EVT for large vessel occlusion (LVO) strokes improves functional outcomes compared to medical management alone, despite higher hemorrhagic transformation rates, with no corresponding increase in symptomatic intracerebral hemorrhage (sICH) rates. The real-world outcomes of this intervention in Indian patients remain underexplored.

Objectives:
To evaluate the real-world outcomes of EVT for large core acute ischemic strokes with LVO in an Indian population.

Methods:
We conducted a single-center, retrospective observational study using a 7 years prospective database of EVT in anterior circulation stroke patients. Patients with Alberta Stroke Program Early Computed Tomography Score (ASPECTS) of 3–5 were included. Clinical and radiologic data were analyzed, with the primary endpoint being 90-day modified Rankin scale (mRS) scores. Safety outcomes included rates of sICH and mortality. Descriptive statistical analysis was done using Microsoft Excel.

Results:
The study included 25 patients who met the inclusion criteria. Mean age of patients was 52.9 ± 14.3 years, and there were 13 (52%) males. Median ASPECTS was 5 (interquartile range 4–5). Successful recanalization, classified by modified Thrombolysis in Cerebral Infarction score, was 92%. Good functional recovery, that is, 90-day mRS 0–3, was achieved in nine (36%) patients. Safety outcomes: sICH was seen in four (16%) and mortality was reported in nine (36%) patients.

Conclusions:
Our results reaffirm findings from RCTs, provide updated real-world evidence, and suggest that EVT is a viable option to be considered in selected patients with large core ischemic infarcts.
Ifosfamide-induced extrapyramidal neurotoxicity with COVID-19
Authors: Nagpal Chitrakshi , Agarwal Ayush , Venkateswaran Vineeta , Soni Kapil D , Srivastava M V Padma , Trikha Anjan 
Published: May 2024

Abstract
Ifosfamide, an analog of cyclophosphamide, is commonly used as a chemotherapeutic agent to treat sarcomas and solid tumors. However, neurotoxicity is a rare side effect of this drug. When present, the symptoms range from confusion, agitation, and delirium in mild cases to mutism, visual blurring, hallucinations, seizures, stupor, and even coma in extreme cases. Within this spectrum, extrapyramidal symptoms are extremely rare, and when present, may not revert with drug discontinuation. Sequelae may occasionally persist even after discontinuation of the drug.
Our case illustrates a rare occurrence of ifosfamide-induced extrapyramidal neurotoxicity in a patient with metastatic phyllodes tumor of the breast and concomitant COVID-19 illness.
Ifosfamide-induced extrapyramidal neurotoxicity is a clinical diagnosis of exclusion and requires ruling out of other possible causes. The diagnosis is supported by a temporal correlation with drug administration, presence of risk factors, and improvement after infusion cessation, along with normal brain imaging.
Enhancement and Digitalization in Healthcare with “THE ARTIFICIAL INTELLIGENCE”
Authors: Goel Neha , Saluja Pulin , Dave Aparna , Arora Manpreet 
Published: May 2024

Abstract
The present review aims at understanding artificial intelligence (AI) in general with special emphasis on the enhancement and digitalization it brought in the various fields of healthcare. Not only it help in the diagnosis and treatment of various diseases but also in the prevention of diseases by aiding in early detection and providing prompt treatment to the patient. It also helps in predicting risk for various diseases thus reducing the morbidity rate. Nowadays, even AI-assisted surgery and robot surgery are being carried out. In fact, in the recent SARS-COVID-19 pandemic, vaccines have been stored under optimal temperature with the use of thermoregulated sensors. Undoubtedly, AI can never completely replace clinicians but it can assist the clinician in providing quality and effective treatment to the patient at every stage from scheduling appointments, documenting it, and maintaining records of the patient’s previous medical history till diagnosis, treatment, and follow-ups. This review covers various applications of AI tools in different health-care sectors from drug and vaccine development to even gene detection. Thus, after review of many articles by the authors, we concluded that AI in healthcare helps in imparting both time and cost-effective, patient-friendly, precise, and quality treatment to the patient. With the emerging advancement and technology in the IT sector, AI is soon going to revolutionized the field of healthcare.
Radiographic Diagnostic Dilemma – A Rare Case Report of Secondary Hyperparathyroidism
Authors: Yadav Preetika , Vohra Puneeta , Chaudhry Astha , Malhotra Kajal , Chauhan Pratibha 
Published: May 2024

Abstract
This case report highlights the role of oral physicians in taking a detailed systemic history along with relevant laboratory investigations to rule out some rarer cases of secondary hyperparathyroidism manifesting in the jaw/mandibular bone. Although radographicaly the tumour site was resembling like Central giant cell granuloma but on detiled laboratory investigations alkaline phospahatase levels (401IU/L)were raised and serum calcium levels were (8.5mg/dl) hence final diagnosis of secondary hyperparathyroidisum was made and pateint was managed by giving vitamin d3 and calcium support rather then surgery. Hence, cases like this draw the attention of oral as well as general physicians to not treat the patient based only on histopathological or radiological findings without proper correlation of clinical and other laboratory investigations.
Comparative Evaluation of Gingival Zenith Position in Maxillary Incisors in Males and Females of Uttarakhand Population
Authors: Tomer Pranshu , Sharma Tarun , Prasad P. Narayana , Rawat Anupa , Grover Anu 
Published: May 2024

Abstract

Introduction:
The entire appearance of face can be virtually transformed in an instant with a smile makeover. One of the most important parameters of clinical importance for gingival morphology is the gingival zenith. Therefore, the aim of the study was the evaluation and establishment of the gingival zenith position (GZP) from the vertical bisecting midline (VBM) axis of each maxillary incisor and the influence of gender on these parameters under healthy conditions.

Materials and Methods:
Frontal intraoral photographs of 200 young individuals (100 males and 100 females) 14–17 years old with healthy gingiva were randomly selected from Uttarakhand population. Their intraoral soft-tissue landmarks were digitized for standardization using Digimizer Image Analysis (6.3.0). Statistical analysis was done using Statistical Package for Social Sciences (22.0.0). We used descriptive statistics to find the mean GZPs. Comparison of mean GZP between males and females was done using Mann–Whitney U-test and comparison of GZP of different tooth types was done employing the Chi-squared test. Significance fixed at P < 0.005.

Results:
For central incisors, mean GZP was 0.77 ± 0.39 mm for males and 0.91 ± 0.42 mm for females, for lateral incisors, 0.48 ± 0.25 mm for males and 0.54 ± 0.31 mm for females. No statistically significant differences were seen between the mean GZP of left central and left and right lateral incisors in male and female populations (P > 0.005). However, statistically significant differences were seen in the mean GZP of right central incisors between males and females (P < 0.005). The mean GZP distance of right central incisors in females was more statistically significant than in males.
Correlation of Diabetes, Hypertension, and Obesity with the Stage of Periodontitis
Authors: Sheokand Vidushi , Bhardwaj Amit , Munjal Neha , Chugh Alisha , Bhatnagar Anurag 
Published: May 2024

Abstract

Background:
Systemic diseases such as diabetes and hypertension may affect periodontium. Increased protein glycosylation from poorly controlled diabetes enhanced glycation end-product synthesis, which in turn triggers the release of inflammatory cytokines and increases the risk of periodontal attachment loss and alveolar bone loss. Alterations in the microcirculation can cause ischemia in the periodontium in hypertension, which may make the situation worse. Its pathophysiology has been postulated to involve oxidative stress and endothelial dysfunction.

Aim:
The current study’s objective is to correlate the blood sugar level, blood pressure, and body mass index (BMI) with the stage of periodontitis.

Materials and Methods:
A total number of 245 patients having periodontitis and gingivitis were examined for systemic parameters which included hypertension, diabetes, and BMI. Glucometer kit is used for measuring random blood glucose, sphygmomanometer is used for measuring blood pressure whereas Omron BMI machine is used for calculating BMI.
Effect of chronic skin disease on female sexual function (FSF) among married Egyptian women
Authors: El-Ammawi Tarek S. , Abdel-Aziz Rasha T.A. , Taha Doaa S. , Mohammed Sahar S. 
Published: May 2024

Background
Female sexual dysfunction (FSD) is a term used to describe various sexual problems, such as low desire or interest, diminished arousal, orgasmic difficulties, and dyspareunia.

Objectives
The aim of the present study was to determine the effect of chronic skin disease on female sexual function among married Egyptian females as well as the prevalence of FSD among them and its effect on their husbands.

Patients and methods
The study was conducted on 300 sexually active married Egyptian women attending the Dermatology Outpatient Clinic of Minia University Hospital and Kom Elshokafa Clinic (Alexandria). All women were asked to fill out the female sexual function index sheet using the Arabic validated translated version of it. Those with FSD were asked about its effect on their husbands.

Results
We reported that 234 (78%) women with chronic skin disease had sexual dysfunction. Despite dysfunction being more common among those who had skin disease, compared with nondysfunction, it was not statistically significantly different among most skin diseases. There was a positive correlation between female’s age and percentage of dysfunction. It was found that only 15.9% of those with FSD showed an effect on their partners in the form of decreased libido.

Limitations
Limitations include the lack of a control group; the standardization of data, which may not be representative of the community, as they related to specific areas; and being a cross-sectional hospital-based study.

Conclusion
Our study revealed a high prevalence of FSD (78%) among Egyptian married women with chronic skin disease in both Minia and Kom Elshokafa (Alexandria) districts. However, it was not statistically significantly different among most skin diseases, with affection of only 15.9% of their partners.