bluuebunny/crossref_metadata_2025_split huggingface dataset:
Integrin β3 and its ligand regulate the expression of uPA through p38 MAPK in breast cancer
Authors: WANG RUI , LI ZHAO‐QING , HAN XU , LI BAI‐LIN , MI XIAO‐YI , SUN LI‐MEI , SONG MIN , HAN YAN‐CHUN , ZHAO YAN , WANG EN‐HUA 
Published: November 2010

Wang R, Li Z‐Q, Han X, Li B‐L, Mi X‐Y, Sun L‐M, Song M, Han Y‐C, Zhao Y, Wang E‐H. Integrin β3 and its ligand regulate the expression of uPA through p38 MAPK in breast cancer. APMIS 2010; 118: 909–17.Interplay between integrins and extracellular matrix is suggested to play an important role in malignant progression and tumor differentiation. The aim of the study was to determine the combined expression of integrin β3 and tenascin‐c (TN‐c) in breast cancer and examine whether integrin β3 and TN‐c can activate urokinase‐type plasminogen activator (uPA) through p38 mitogen‐activated protein kinase (p38 MAPK). We detected the expression of integrin β3, TN‐c, p‐p38, and uPA in 80 cases of breast invasive ductal carcinoma by immunohistochemistry. In addition, we blocked integrin β3 and TN‐c in the MDA‐MB‐231 breast cancer cells and detected the expression of p‐p38 and uPA by Western blot. Integrin β3, TN‐c, p‐p38, and uPA showed high levels of expression in breast invasive ductal carcinoma. The expression of integrin β3, TN‐c, and uPA was correlated with lymph node metastasis and TNM stage in breast cancer. Furthermore, correlations were noted between any two of the three proteins. The expression of p‐p38 and uPA decreased in MDA‐MB‐231 cells after the addition of integrin β3 antibody and TN‐c antibody. The expression of uPA decreased after addition of SB203580. Our results demonstrate that inhibition of the expression of integrin β3 and TN‐c could decrease the expression of uPA through p38 MAPK in breast cancer, suggesting that the interaction between integrin β3 and TN‐c serves an important role in breast cancer.
On the Speeds of Instability of a Rotating Hollow, Anisotropic
Cylinder
Authors: Lenard J. G. 
Published: November 2010

Abstract
Hill's theory of plastic anisotropy is used to investigate the effect of the parameters of anisotropy on the speeds at which long, hollow cylinders rotating about their longitudinal axes reach their maximum load carrying ability. Taking the principal axes of anisotropy to coincide with the principal stress directions and considering true stresses and logarithmic strains a relationship between the tangential strain at the bore and the rotational speed is derived and the rotational speed at which fracture due to instability may begin is noted. It is found that decreasing yield strength in the axial direction results in increased load carrying capacity.
Numerical Simulation of Natural Convection in Closed Containers by a
Fully Implicit Method
Authors: Pepper D. W. , Harris S. D. 
Published: November 2010

Abstract
Numerical solutions have been obtained for two-dimensional free convective flow in rectangular and annular cavities by the strongly implicit procedure (SIP) and the cyclic reduction-fast Fourier transform (CR-FFT) technique. Rayleigh numbers range from 104 to 106, Prandtl numbers from 0.713 to 103, radius ratios from 1 to 3 (annular cavities), and aspect ratios (height/width) from 1 to 15. Motion is generated by either uniformly heating the bottom wall or heating a vertical wall and cooling the opposite wall. Both time-dependent and steady-state solutions confirm results previously obtained by others. Because SIP uses a common set of matrix algorithms, the governing equations of motion can be solved simultaneously without major modification to the method for each equation.
Numerical Modeling of Unsteady, Separated Viscous
Flow
Authors: Giaquinta A. R. 
Published: November 2010

Abstract
Numerical solutions of the equations governing the laminar flow of an incompressible fluid through a two-dimensional sudden expansion are discussed. The fluid motion is started impulsively from rest and is examined in detail during the transient phase to the steady-state condition. Solutions are obtained by two independent finite-difference methods which are discussed. The development of the flow in the zone of separation is investigated, and, during the earliest phases of motion, the generation of vorticity at the solid boundaries and its spatial diffusion is studied in the region of uniform flow. The numerical treatment of the boundary conditions is discussed. Characteristics of the transient solution for two different Reynolds numbers in the laminar range are presented. Included with the results is the temporal development of the streamline dividing the zone of separation from the main flow.
Prediction of the Three-Dimensional Velocity Field of a Deflected
Turbulent Jet
Authors: Patankar S. V. , Basu D. K. , Alpay S. A. 
Published: November 2010

Abstract
The paper describes the results of a finite-difference solution for the three-dimensional flow field generated by a round turbulent jet deflected by a main stream normal to the jet axis. The Reynolds stresses in the time-averaged momentum equations are calculated by a “two-equation turbulence model” in which differential equations are solved for the kinetic energy of turbulence and for the rate of its dissipation. The solution procedure employs an elliptic finite-difference scheme with the three velocity components and the pressure as the main dependent variables. Results are presented for the cases in which the ratio of the jet velocity to the main-stream velocity ranges from 2 to 10. The numerical predictions are shown to agree well with available experimental data.
Lubrication Review—A Digest of the Literature for
1968
Authors: Rumbarger J. H. , Liu J. Y. , Adams M. L. , Colsher R. J. , Poplawski J. V. , Galate J. W. , Schroeder R. J. , Roberts W. L. , Myers H. , Devine M. J. 
Published: November 2010

Abstract
The volume of lubrication literature continued to expand, reflecting the increased experimental and theoretical attention being focused upon this discipline. Eight categories of lubrication technology are summarized by authorities in each particular field. 481 reference publications are included in the review.
An Analytical Study of the Stress Concentration Around a Furrow
Shaped Surface Defect in Rolling Contact
Authors: Chiu Y. P. , Liu J. Y. 
Published: November 2010

Abstract
This paper presents a simple model for the stress concentration around a furrow shaped surface defect in rolling contact. An idealized two-dimensional defect profile, consisting of two curved shoulders smoothly connected to the remaining surface of an elastic half space under compression, is considered. The “undisturbed” stress state in the contacting cross section plane is assumed to be hydrostatic compression, corresponding to the “localized” stress state near the surface in the contact zone of two cylinders in contact. Numerical results are obtained for the contact pressure distribution and subsurface stress (octahedral shear stress). In this solution, which corresponds to the particular undisturbed stress state, the maximum value of the octahedral yield stress occurs underneath the curved “shoulders” of the defect.
On Immunologists and Microbiologists: Ground Zero in the Battle for Interdisciplinary Knowledge
Authors: Biron Christine A. , Casadevall Arturo 
Published: November 2010

ABSTRACT
The individual disciplines of microbiology and immunology are exploding with new information necessary for understanding host-pathogen relationships, infectious diseases, cancer, and autoimmunity. Because of overlapping scientific interests, immunologists and microbiologists often share common academic affiliations. The coexistence is uneasy. Significant problems arise because the groups have evolved different intellectual traditions. Pressures are intensified by sporadic changes in perceptions of their relative worth. As the mixing of microbiologists and immunologists can be likened to ground zero in the fight for interdisciplinary knowledge, it is useful, at this time of escalating data acquisition and growing appreciation for multidisciplinary research, to examine their histories, the challenges to amalgamation, and the advantages of their association for the advancement of knowledge and the delivery of protection against disease. The exploration supports a recommitment to integration of the disciplines and a proposal to facilitate this by inclusion of expertise bridging the areas.
Differential expression of apoptosis-related genes from death receptor pathway in chronic myeloproliferative diseases
Authors: Tognon Raquel , Gasparotto Elainy Patrícia Lino , Leroy Janine Marie Gisele , Oliveira Gislane Lelis Vilela , Neves Renata Peres , Carrara Rita de Cássia Viu , Kashima Simone , Covas Dimas Tadeu , Santana Mary , Souto Elizabeth Xisto , Zanichelli Maria Aparecida , Velano Carlos Eduardo Engel , Simões Belinda Pinto , Alberto Fernando Lopes , Miyashiro Kozue , de Souza Ana Maria , Amarante-Mendes Gustavo Pessini , de Castro Fabíola Attié 
Published: November 2010

BackgroundChronic myeloproliferative disorders (MPDs) are clonal haematopoietic stem cell malignancies characterised by an accumulation of mature myeloid cells in bone marrow and peripheral blood. Deregulation of the apoptotic machinery may be associated with MPD physiopathology.AimsTo evaluate expression of death receptors' family members, mononuclear cell apoptosis resistance, and JAK2 allele burden.Subjects and MethodsBone marrow haematopoietic progenitor CD34 cells were separated using the Ficoll-hypaque protocol followed by the Miltenyi CD34 isolation kit, and peripheral blood leukocytes were separated by the Haes-Steril method. Total RNA was extracted by the Trizol method, the High Capacity Kit was used to synthesise cDNA, and real-time PCR was performed using SybrGreen in ABIPrism 7500 equipment. The results of gene expression quantification are given as 2−ΔΔCt. The JAK2 V617F mutation was detected by real-time allelic discrimination PCR assay. Peripheral blood mononuclear cells (PBMCs) were isolated by the Ficoll-hypaque protocol and cultured in the presence of apoptosis inducers.ResultsIn CD34 cells, there was mRNA overexpression forfas,faimandc-flipin polycythaemia vera (PV), essential thrombocythaemia (ET) and primary myelofibrosis (PMF), as well asfaslin PMF, anddr4levels were increased in ET. In leukocytes,fas,c-flipandtraillevels were increased in PV, anddr5expression was decreased in ET. There was an association betweendr5andfaslexpression and JAK2V617F mutation. PBMCs from patients with PV, ET or PMF showed resistance to apoptosis inducers.ConclusionsThe results indicate deregulation of apoptosis gene expression, which may be associated with MPD pathogenesis leading to accumulation of myeloid cells in MPDs.
Re-assessment of the stock–recruit and temperature–recruit relationships for Pacific sardine (Sardinops sagax)
Authors: McClatchie Sam , Goericke Ralf , Auad Guillermo , Hill Kevin 
Published: November 2010

The harvest guideline for Pacific sardine ( Sardinops sagax ) incorporates an environmental parameter based on averaged surface temperatures at the Scripps Institution of Oceanography pier (SIO pier) in La Jolla, California, USA, which would be invoked after a series of cool years to reduce commercial catches using a precautionary decision rule. We revisit the stock–recruit and temperature–recruit relationships underpinning the currently used environmental parameter for sardine assessment and found that the temperature–recruit relationship no longer holds for the SIO pier when time series are updated with data from more recent years. The significance of the correlation between temperature and recruitment was also artificially increased by autocorrelation in the time series. In contrast, the stock–recruit relationship was still valid when recent data were added. SIO pier surface temperatures are warmer than 10 m-depth Southern California Bight (SCB) temperatures where the sardine spawn, and the difference has increased since the late 1970s. Sardine recruitment was also not related to offshore temperatures in the SCB. We demonstrate that the environmental proxy derived from SIO pier temperature, which has never affected the harvest guideline since its implementation, no longer predicts recruitment of Pacific sardine, and should be removed from sardine management.
Ditylenchus halictus n. sp. (Nematoda: Anguinidae), an associate of the sweat bee, Halictus sexcinctus (Halictidae), from Germany
Authors: Giblin-Davis Robin M. , Erteld Christian , Kanzaki Natsumi , Ye Weimin , Zeng Yongsan , Center Barbara J. 
Published: November 2010

Abstract
Ditylenchus halictus n. sp. was collected as dauer juveniles from the genital
region of adult males and females of the soil-dwelling sweat bee, Halictus
sexcinctus (Halictidae), in Brandenburg, Germany, and cultured on the
fungus, Monilinia fructicola. It is the first species of Ditylenchus to be
reported in an active phoretic association with insects and is described and
illustrated herein. Dissections revealed that 25% of female bees carried the
dauer juveniles of D. halictus n. sp. internally in the Dufour's gland
and/or seminal receptacle and/or genital region (range 1-193 dauer juveniles
per bee), and 38% of males were infested in the genital capsule, copulation
apparatus, and/or distal testes with 1-64 dauer juveniles. Morphologically,
D. halictus n. sp. has six lines in the lateral field and appears closest to
D. myceliophagus but can be differentiated based upon a combination of
morphological characters, the mode of reproduction and molecular sequence
data. Molecular analysis of the near full length SSU rDNA, D2/D3 expansion
segments of the large subunit (LSU) rDNA, and internal transcribed spacers
(ITS-1 and 2) and 5.8S rDNA support that this nematode species is
unique.
Diversity and distribution of entomopathogenic nematodes in Chile
Authors: Edgington Steve , Buddie Alan G. , Moore Dave , France Andrés , Merino Loreto , Tymo Lukasz M. , Hunt David J. 
Published: November 2010

Abstract
A systematic programme of surveys for entomopathogenic nematodes (EPN) was
done in Chile between 2006 and 2008. The survey spanned the principal
ecosystems of mainland Chile as well as a number of islands, and covered a
wide range of habitats including the Atacama Desert, Andean Altiplano,
temperate rainforests and subpolar territory. Nearly 1400 soil samples were
collected, of which 7% were positive for EPN. Of 101 EPN isolates obtained,
94 were Steinernema spp. and seven were Heterorhabditis sp. Of the 94
Steinernema isolates, 39 were identified as Steinernema feltiae, the
remainder being distributed between two new species, S. unicornum (52
records) and S. australe (three records). The Heterorhabditis isolates, all
designated as Heterorhabditis sp.1, are referred to herein as H. cf.
safricana. Steinernema feltiae and S. unicornum were collected predominately
in the south of Chile and were obtained from a range of habitats, including
forests, open grassland, montane soils and coastal zones; neither species
was recovered from the far north of the country (viz., desert soils in the
Norte Grande region). Steinernema australe was found in only three soil
samples, all from humid, cool, coastal localities in the south.
Heterorhabditis cf. safricana was recovered from the northern regions, with
most isolates found in or on the periphery of the Atacama Desert; they were
not recovered from cooler, more humid regions of southern Chile. Molecular
information indicated there were two subgroups of both S. unicornum and S.
feltiae, with a geographical, intraspecific split of subgroups between the
most southerly and the more central survey zones. All isolates were
collected by ex situ baiting with waxmoth larvae and the natural hosts are
unknown.
Paleoecology of commensal epizoans foulingFlexicalymene(Trilobita) from the Upper Ordovician, Cincinnati Arch region, USA
Authors: Key Marcus M. , Schumacher Gregory A. , Babcock Loren E. , Frey Robert C. , Heimbrock William P. , Felton Stephen H. , Cooper Dan L. , Gibson Walter B. , Scheid Debbie G. , Schumacher Sylvester A. 
Published: November 2010

Commensal epizoozoans and episkeletozoans are rarely preserved attached to the external exoskeleton of the Late Ordovician trilobiteFlexicalymene.Of nearly 15,000Flexicalymenespecimens examined, 0.1% show epizoozoans or episkeletozoans. Factors limitingFlexicalymenefouling include a shallow burrowing life style, frequent molting of the host, larval preference for other substrates, observational bias caused by overlooking small fouling organisms, and the loss of the non-calcified, outermost cuticle prior to fossilization or as the trilobite weathers from the encasing sediment. Trepostome bryozoans, articulate and inarticulate brachiopods, cornulitids, and a tube-dwelling/boring nonbiomineralized organism represent the preserved members of the Late Ordovician marine hard substrate community foulingFlexicalymene.This assemblage of organisms is less diverse than the hard substrate community fouling Late Ordovician sessile epibenthic organisms. Fouling is not restricted to only largeFlexicalymenespecimens as observed in previous studies but occurs in medium to large individuals interpreted as early to late holaspid specimens.Epizoozoans fouling the carcasses or molt ensembles of 16Flexicalymenespecimens provide insight into the life habits of the host and these fouling organisms. Trepostome bryozoans, articulate and inarticulate brachiopods, and cornulitids preferentially attached to elevated portions of the dorsal exoskeleton, and preferentially aligned in either the direct line or lee side of currents generated byFlexicalymenewalking on the sea floor or swimming through the water column.
Inversion tectonics at the northern margin of the Paris basin (northern France): new evidence from seismic profiles and boreholes interpolation in the Artois area
Authors: Minguely Bruno , Averbuch Olivier , Patin Marie , Rolin David , Hanot Franck , Bergerat Francoise 
Published: November 2010

AbstractA synthesis of existing borehole data and seismic profiles has been conducted in the Artois area (northern France), along the northern border of the Paris basin, in order to explore the possible control exerted at depth by the Upper Carboniferous Variscan thrust front on the distribution of Late Paleozoic-Mesozoic depositional centers and their subsequent uplift in Tertiary times. Such control was demonstrated recently in the Weald-Boulonnais basin (Eastern Channel area) that forms the western prolongation of the area under study but was so far poorly constrained in the Artois area. Presented data provide evidence for the topography of the Artois hills and the altitude of sedimentary layers to be controlled by the activity of a network of relaying WNW-ESE striking faults inducing the systematic uplift of the southern fault blocks. Those steeply S-dipping faults branch downward onto the ramp of the Variscan thrusts forming listric faults that locally limit to the north buried half-graben structures, filled with fan-shaped fluviatile Stephanian-Permian deposits. Such clear syn-rift geometry shows that the ramp of the main Variscan frontal thrust (the Midi thrust) has been reactivated as a normal fault in Stephanian-Permian times thus forming a very demonstrative example of a negative inversion process. The reverse offset of the transgressive Middle Cretaceous-Lower Eocene layers covering unconformably the Paleozoic substratum argue for a Tertiary (Middle Eocene-Late Oligocene?) contractional reactivation of the fault network thereby documenting a repeated inversion process along the Artois Variscan thrust front. The Variscan frontal thrust zone is thus shown here to represent a prominent crustal-scale mechanical discontinuity that localized deformation in the Artois-Boulonnais area since Upper Paleozoic times.
Des pompes et des hommes
Authors: Gangneron Fabrice , Becerra Sylvia , Hamath Dia Amadou 
Published: November 2010

Depuis les années 1990, la commune sahélienne de Hombori s’est vue dotée de pompes à motricité humaine destinées aux usages domestiques. Simples d’usage et peu coûteuses leur gestion semble adaptée à des populations pauvres. Pourtant la nécessité de recourir au marché pour le changement de pièces détachées constitue une situation inédite là où l’eau est d’ordinaire gratuite. En fait, les bailleurs imposent leurs cadres : des « comités de gestion » qui se chargent d’organiser les paiements des usagers ; mais certains comités restent totalement inactifs tandis que d’autres réinventent des formes de gestions originales ou l’accès à l’eau pour tous ne constitue pas l’unique enjeu. Cet article montre ainsi que le dessein qui vise à séparer la gestion des pompes des autres aspects économiques et sociaux n’est pas opérationnel. Enfin, les processus qui conduisent à l’installation des pompes montrent que les engagements politiques qui consistent à susciter la participation des populations ne résistent que rarement à l’épreuve des faits.
Tunable and Reversible Adhesive of Liquid Metal Ferrofluid Pillars for Magnetically Actuated Noncontact Transfer Printing
Authors: Jiang Jing , Li Chenglong , Chen Chenhong , Shi Chuanqian , Song Jizhou 
Published: May 2024

AbstractTransfer printing techniques based on tunable and reversible adhesives enable the heterogeneous integration of materials in desired layouts and are essential for developing both existing and envisioned electronic systems. Here, a novel tunable and reversible adhesive of liquid metal ferrofluid pillars for developing an efficient magnetically actuated noncontact transfer printing is reported. The liquid metal ferrofluid pillars offer the appealing advantages of gentle contact force by minimizing the preload effect and exceptional shape adaptability by maximizing the interfacial contact area due to their inherent fluidity, thus enabling a reliable damage‐free pickup. Moreover, the liquid metal ferrofluid pillars harness the rapid stiffness increase and shape change with the magnetic field, generating an instantaneous ejection force to achieve a receiver‐independent noncontact printing. Demonstrations of the adhesive of liquid metal ferrofluid pillars in transfer printing of diverse objects with different shapes, materials and dimensions onto various substrates illustrate its great potential in deterministic assembly.