bluuebunny/crossref_metadata_2025_split huggingface dataset:
GCC banks liquidity and financial performance: does the type of financial system matter?
Authors: Bilal Zaroug , AlGhazali Abdullah , Samour Ahmed 
Published: May 2024

AbstractThis study examines whether the type of financial structure in the GCC influences the relationship between liquidity risk and banks’ performance from 2007 to 2021. By employing fixed effects and fully modified ordinary least squares (FMOLS), we find that the impact of liquidity risk on bank profitability differs among bank-based and market-based systems. Specifically, the results show that the profitability of banks operating in bank-based countries is positively influenced by the liquidity risk compared to their counterparts. The study also demonstrates that the global financial crisis increases banks’ profitability in the bank-based financial system. Furthermore, the results show that gross domestic product growth (GDPG) determines banks’ financial profitability in the banks-based market. This study offers some important implications for policymakers to consider the type of financial system to stimulate bank stability.
Signaling pathways in liver cancer: pathogenesis and targeted therapy
Authors: Xue Yangtao , Ruan Yeling , Wang Yali , Xiao Peng , Xu Junjie 
Published: May 2024

AbstractLiver cancer remains one of the most prevalent malignancies worldwide with high incidence and mortality rates. Due to its subtle onset, liver cancer is commonly diagnosed at a late stage when surgical interventions are no longer feasible. This situation highlights the critical role of systemic treatments, including targeted therapies, in bettering patient outcomes. Despite numerous studies on the mechanisms underlying liver cancer, tyrosine kinase inhibitors (TKIs) are the only widely used clinical inhibitors, represented by sorafenib, whose clinical application is greatly limited by the phenomenon of drug resistance. Here we show an in-depth discussion of the signaling pathways frequently implicated in liver cancer pathogenesis and the inhibitors targeting these pathways under investigation or already in use in the management of advanced liver cancer. We elucidate the oncogenic roles of these pathways in liver cancer especially hepatocellular carcinoma (HCC), as well as the current state of research on inhibitors respectively. Given that TKIs represent the sole class of targeted therapeutics for liver cancer employed in clinical practice, we have particularly focused on TKIs and the mechanisms of the commonly encountered phenomena of its resistance during HCC treatment. This necessitates the imperative development of innovative targeted strategies and the urgency of overcoming the existing limitations. This review endeavors to shed light on the utilization of targeted therapy in advanced liver cancer, with a vision to improve the unsatisfactory prognostic outlook for those patients.
Visualization of scientific production in Caenorhabditis elegans: a bibliometric analysis (1980–2023)
Authors: Berk Şeyda , Özdemir Serkan , Pektaş Ayşe Nur 
Published: May 2024

AbstractCaenorhabditis elegans (C. elegans) is a nematode and model organism whose entire genome has been mapped, which allows for easy observation of the organism’s development due to its transparent structure, and which is appealing due to its ease of crossover, ease of culture, and low cost. Despite being separated by nearly a billion years of evolution, C. elegans homologs have been identified for the vast majority of human genes and are associated with C. elegans for many biological processes such as apoptosis, cell signaling, cell cycle, cell polarity, metabolism, and aging. A detailed bibliometric study is performed here to examine publication trends in this field. Data were taken from the Web of Science database and analyzed using the bibliometric application Biblioshiny (RStudio). In terms of publication, the results indicated a gradual increase each year between 1980 and 2023. A total of 20,322 records were issued in 96 countries, the majority of which were in the USA, China, and Japan. The most prolific writers, the journals most engaged in the area, the nations, institutions, and keywords used by authors were all determined using the Web of Science database and bibliometric rules. The number of papers in the C. elegans research field is increasing exponentially, and Genetics is the journal with the highest number of articles. This study presents how research patterns have evolved throughout time. As a result, worldwide cooperation and a potential field can be developed.
Identification of pleiotropic and specific therapeutic targets for cardio-cerebral diseases: A large-scale proteome-wide mendelian randomization and colocalization study
Authors: Zhu Yanchen , Wang Yahui , Cui Zhaorui , Liu Fani , Hu Jiqiang 
Published: May 2024

BackgroundThe cardiac-brain connection has been identified as the basis for multiple cardio-cerebral diseases. However, effective therapeutic targets for these diseases are still limited. Therefore, this study aimed to identify pleiotropic and specific therapeutic targets for cardio-cerebral diseases using Mendelian randomization (MR) and colocalization analyses.MethodsThis study included two large protein quantitative trait loci studies with over 4,000 plasma proteins were included in the discovery and replication cohorts, respectively. We initially used MR to estimate the associations between protein and 20 cardio-cerebral diseases. Subsequently, Colocalization analysis was employed to enhance the credibility of the results. Protein target prioritization was based solely on including highly robust significant results from both the discovery and replication phases. Lastly, the Drug-Gene Interaction Database was utilized to investigate protein-gene-drug interactions further.ResultsA total of 46 target proteins for cardio-cerebral diseases were identified as robust in the discovery and replication phases by MR, comprising 7 pleiotropic therapeutic proteins and 39 specific target proteins. Followed by colocalization analysis and prioritization of evidence grades for target protein, 6 of these protein-disease pairs have achieved the highly recommended level. For instance, the PILRA protein presents a pleiotropic effect on sick sinus syndrome and Alzheimer’s disease, whereas GRN exerts specific effects on the latter. APOL3, LRP4, and F11, on the other hand, have specific effects on cardiomyopathy and ischemic stroke, respectively.ConclusionsThis study successfully identified important therapeutic targets for cardio-cerebral diseases, which benefits the development of preventive or therapeutic drugs.
Diagnostic performance of ultrasound-based artificial intelligence for predicting key molecular markers in breast cancer: A systematic review and meta-analysis
Authors: Fu Yuxia , Zhou Jialin , Li Junfeng 
Published: May 2024

Background
Breast cancer (BC) diagnosis and treatment rely heavily on molecular markers such as HER2, Ki67, PR, and ER. Currently, these markers are identified by invasive methods.

Objective
This meta-analysis investigates the diagnostic accuracy of ultrasound-based radiomics as a novel approach to predicting these markers.

Methods
A comprehensive search of PubMed, EMBASE, and Web of Science databases was conducted to identify studies evaluating ultrasound-based radiomics in BC. Inclusion criteria encompassed research on HER2, Ki67, PR, and ER as key molecular markers. Quality assessment using Quality Assessment of Diagnostic Accuracy Studies (QUADAS-2) and Radiomics Quality Score (RQS) was performed. The data extraction step was performed systematically.

Results
Our meta-analysis quantifies the diagnostic accuracy of ultrasound-based radiomics with a sensitivity and specificity of 0.76 and 0.78 for predicting HER2, 0.80, and 0.76 for Ki67 biomarkers. Studies did not provide sufficient data for quantitative PR and ER prediction analysis. The overall quality of studies based on the RQS tool was moderate. The QUADAS-2 evaluation showed that the studies had an unclear risk of bias regarding the flow and timing domain.

Conclusion
Our analysis indicated that AI models have a promising accuracy for predicting key molecular biomarkers’ status in BC patients. We performed the quantitative analysis for HER2 and Ki67 biomarkers which yielded a moderate to high accuracy. However, studies did not provide adequate data for meta-analysis of ER and PR prediction accuracy of developed models. The overall quality of the studies was acceptable. In future research, studies need to report the results thoroughly. Also, we suggest more prospective studies from different centers.
Normalized solutions of NLS equations with mixed nonlocal nonlinearities
Authors: Zhang Zhenyu , Sun Juntao 
Published: May 2024

Abstract
We study the existence and nonexistence of normalized solutions for the nonlinear Schrödinger equation with mixed nonlocal nonlinearities:

−
Δ
u
=
λ
u
+
μ

(

I

α

∗

∣
u
∣

p

)

∣
u
∣

p
−
2

u
+

(

I

α

∗

∣
u
∣

q

)

∣
u
∣

q
−
2

u

in

R

N

,

∫

R

N

∣
u
∣

2

d
x
=
c
,

\left\{\begin{array}{ll}-\Delta u=\lambda u+\mu \left({I}_{\alpha }\ast {| u| }^{p}){| u| }^{p-2}u+\left({I}_{\alpha }\ast {| u| }^{q}){| u| }^{q-2}u& \hspace{0.1em}\text{in}\hspace{0.1em}\hspace{0.33em}{{\mathbb{R}}}^{N},\\ \mathop{\displaystyle \int }\limits_{{{\mathbb{R}}}^{N}}{| u| }^{2}{\rm{d}}x=c,& \end{array}\right.

where

N
≥
1
,

N
+
α

N

≤
p
<
q
≤

N
+
α
+
2

N

N\ge 1,\frac{N+\alpha }{N}\le p\lt q\le \frac{N+\alpha +2}{N}

, the parameter

μ
∈
R

\mu \in {\mathbb{R}}

and

λ

\lambda

is a Lagrange multiplier. Furthermore, we prove the relationship between minimizers and ground state solutions under the Nehari manifold, which seems to be the first result in the nonlocal context.
Leadership among African Independent Churches
Authors: Oduro Thomas 
Published: May 2024

Abstract
African Independent Churches are known to be the fourth segment of Christianity in Africa – after Roman Catholics and Orthodox Churches, and Western Protestant Churches. The early leaders had no books to read about leadership, no Bible Colleges and Seminaries where they learned about leading people. They did not have the opportunity to attend conferences and seminars on leadership. The means of getting information were scant. Despite all these challenges, they commanded thousands and even millions of people today and are influential. Some of their leaders were and are deified. This paper looks at the leadership qualities and dynamics of African Independent Churches to the extent that some of their leaders were and are treated as demigods. They have introduced a new style of leadership to African Christianity, which is gradually becoming the norm in most churches.
Cooling Down to Level Up: Does Interset Palm or Sole Cooling Enhance Resistance Training Performance?
Authors: Burke Ryan , McMahon Gerard , Schoenfeld Brad J. 
Published: May 2024

ABSTRACT
An emerging body of research has explored the potential ergogenic effects of noninvasive interset recovery strategies involving the application of cold substances to the extremities distal to exercising muscles (e.g., palms of the hands or the soles of the feet). It was suggested that such strategies may acutely enhance resistance training (RT) performance by augmenting excitation and motor unit recruitment of the working muscles through enhanced stimulation of the central nervous system, resulting in greater force production and the ability to perform more repetitions to fatigue. Moreover, peripheral stimuli such as distal cooling may acutely reduce the sensation of distress during RT, allowing individuals to tolerate more exercise and achieve higher training volumes. Although there is some evidence that interset distal cooling confers an ergogenic benefit during RT, certain methodological considerations, a paucity of longitudinal research, and contrasting findings call into question its effectiveness. Thus, the purpose of this review is to assess the current evidence regarding the effects of interset palm and sole cooling on RT performance outcomes.
Coding and Payment in Pediatrics: The A, B, Cs of Being Paid for the Care You Give
Authors:   American Academy of Pediatrics
Published: May 2024

This article reviews key points from “Coding and Payment in Pediatrics: The A, B, Cs of Being Paid for the Care You Give,” an American Academy of Pediatrics (AAP) coding webinar presented by Shannon Fox-Levine, MD, FAAP, including the following:
How payment affects patient access Appropriate coding and billing practices Contract terms Avoiding and fighting inappropriate denials Looking beyond fee-for-service payment State and national resources for addressing payment issues
Factors Contributing to the Enhancement of Feasibility in Public–Private Partnership During Disasters
Authors: Torayashiki Tetsuya , Watanabe Kenji 
Published: May 2024

This study aims to quantitatively identify the factors associated with	companies that actively enhance the feasibility of public–private	partnerships (PPP) during disasters. Based on these identified	relationships, the study seeks to propose strategies to improve PPP	effectiveness in proactive companies. A questionnaire survey was conducted	targeting companies in Japan that have concluded disaster assistance	agreements with local governments. Based on the response data, scales were	constructed for the following variables: “feasibility of public–private	agreements (FPPA),” “experience in implementing public–private agreements	(EPPA),” “social contribution to disaster-stricken area,”	“implementation level of disaster risk reduction measures,”	“feasibility of business continuity,” “organizational culture	toward risk and crisis (OCRC),” and “employee autonomy (EA).” Path	analysis was conducted to investigate the relationships between FPPA and	other variables. The results revealed that FPPA is associated with EPPA, EA,	and OCRC. In terms of strategies to improve FPPA, it was suggested to	promote the internal sharing of information about EPPA from other companies.	Additionally, for EA and OCRC, implementing human resource policies and	management practices was discussed as potential measures.
Obstructive uropathy secondary to accidental ureteric placement of indwelling urinary catheter at time of caesarean section
Authors: Hariz Sara , Pradhan Priti 
Published: May 2024

Abstract

This case describes a rare complication of Foley catheter insertion where accidental instrumentation of a ureter occurred at time of caesarean section with subsequent development of bladder obstruction and acute kidney injury. This has only been documented in literature a handful of times however rapid identification and management can minimise associated long term implications. As such this necessitates greater awareness of this possible complication and risk factors such as pregnancy that may predispose patients.
Study on radiographic grading of ankle joint in adult patients with Kashin Beck disease in Shaanxi and Gansu Province, China
Authors: Zheng-ming Sun , Fei-xiang Miao , Xin-Ke Zhu , Zhan-kui Jin , Xue-yuan Wu , shi-xun Wu , Shi-zhang Liu , Ming Chen , Xin Tian , Ming Ling 
Published: May 2024

Abstract

Purpose
This paper aims to establish an X-ray imaging grading for assessing ankle joints in adult Kashin Beck disease (KBD), and investigate its correlation with clinical grading of hand and ankle pain.
Methods
The study involved 160 adult KBD patients (a total of 320 ankles) as the case group and 100 matched healthy subjects (a total of 200 ankles) as the control group. Digital Radiographs of bilateral ankle joints were obtained, and the talus trochlea angle was measured according to the radiographs. The X-ray grading of adult KBD ankles was conducted using the Kellgren Lawrence grading as a reference. Correlation analysis was performed to study the relationship between X-ray grading and clinical grading of hand.
Result
The X-ray imaging of KBD ankle joints was categorized into grade 0-IV, with grade IV further divided into subtypes a, b, c, and d. There was no correlation between ankle X-ray grading and the clinical grading of the hands in patients with KBD (r = 0.208, p = 0.001). There was a significant correlation between X-ray grading and ankle pain (r = 0.610, p = 0.000), but no correlation between ankle pain and the clinical grading of hand (r = 0.101, p = 0.071).
Conclusion
This study introduced an X-ray grading method for KBD ankles, although it showed no correlation with the clinical grading of the hands. Importantly, a moderate correlation was identified between X-ray grading and ankle pain, but no significant link was established between ankle pain and the clinical grading of hand.
Disease profile and main outcomes of COVID 19 in a population with nephrologic concern: a mono centric study
Authors: Salah Manel Ben , Mahmoud Nouha Ben , Hafi Khouloud , Fredj Manel Ben , salem Mariem ben , Bchir Sirine , Letaief Ahmed , Aloui Sabra , Hamouda Mouna , Skhiri Habib 
Published: May 2024

Abstract

Background:
Patients with CKD as well as patients who developed acute renal failure both affected by SARS-COV2 have a poor disease prognosis. The aim of our work: is to study the profile and outcomes of COVID 19 in patients with nephrology concern
Methods:
The patients included were chronic renal patients, kidney transplanted recipients and patients who developed acute renal failure. Patients were recruited over a period of one year.
Results:
We included 165 patients with a mean age of 57 years. There was a slight male predominance. Our patients had three main diseases (hypertension: 61.8%, diabetes: 44% and cardiovascular disease: 19%) and were obese in a third of cases. Chronic kidney disease accounted for 85% of patients. The death rate was 15.8%.
The main complications were acute renal failure: 16.4%, worsened chronic renal failure 32.7%, pulmonary bacterial super infection: 23.6% and a moderate or severe form of COVID in 57% of cases. The main conclusions of the analytic study were: a significantly positive association of severe COVID 19 with advanced age (p=0.001), hypertension (63.7%, p=0.012), diabetes (66.2%, p=0.018), underlying heart disease (75%, p=0.017) and renal patients not necessitating renal replacement therapy (67.5%, p=0.044). The clinical signs most associated with moderate and severe forms of the disease (MSD) were asthenia (63.4%, p=0.024), fever (68.6%, p=00.1) and dry cough (71%, p=0.001). The main complications significantly associated with Moderate or Severe Disease were ARF (77.8%, p=0.017) and bacterial pulmonary super infection (94.9%, p<0.001). In multivariate analysis, pulmonary bacterial super infection and dry cough are clearly associated with MSD: respective OR were 37.23 and 3.434. Diarrhea appears to be a factor associated with mild forms of COVID 19 as evidenced by an OR of 0.374. Increasing age by one year multiplies the risk of developing a severe form of COVID 19 disease by 1.044.
Conclusion:
According to our study, the most serious COVID patients are the elderly, hypertensive, diabetic, cardiopathic patients and, above all, those who develop ARF. Some clinical symptoms and biological findings were correlated with severe disease but the strongest indicators are asthenia, dry cough and advanced age.
Trial registration: not done as we did not make any health care intervention on study participants
Biomechanical Coordination and Variability Alters Following Repetitive Movement Fatigue in Athletes with Painful Shoulder
Authors: Sheikhhoseini Rahman , Abdollahi Sajjad , Salsali Mohammad , Anbarian Mehrdad 
Published: May 2024

Abstract

Background
Most sports and leisure activities involve repetitive movements in the upper limb, which are typically linked to pain and discomfort in the neck and shoulder area. Movement variability is generally expressed by changes in movement parameters from one movement to another and is a time-dependent feature of repetitive activities. The purpose of this study was to examine the effect of repeated movement induced fatigue on biomechanical coordination and variability in athletes with and without chronic shoulder pain (CSP).
Methods
In this controlled laboratory study, 24 elite male badminton players in two groups of athletes with (N = 12) and without (N = 12) CSP were recruited. Biomechanical and Electromyographical data were recorede while the athletes asked to perform repeating reaching task (RRT). Kinematic data was recorded every 30 seconds of the minutes of the repetitive pointing task (RPT). The kinematic and electromyography data were recorded at the first 30 seconds of "Fatigue-Terminal" (FT) and the last 30 seconds of "No-Fatigue" (NF) in the repetitive pointing task (RPT). Raw data was analyzed by using MATLAB code to extract the relevant coordination and movement variability data.
Results
different fatigue conditions (non-fatigue and terminal fatigue) led to significant kinematic changes during the performance of the repetitive pointing task. The CSP group exhibited smaller variability after fatigue than before fatigue. Moreover, altered coordination between trunk movement and shoulder elevation were recorded after fatigue. In addition, the variability of the shoulder muscles in both groups was significantly differ after fatigue (P < 0.05).
Conclusions
Results of our study show that both groups can accomplish the repetitive movement task but in doing so use different movement strategies. The CSP group’s movement strategy was only focused on controlling the shoulder joint, while that of the CON group was focused both on the shoulder joint and elbow joint. This suggests that chronic pain may have found a pain–minimizing strategy to accomplish the task
A topological route to engineering robust and bright supersymmetric laser arrays
Authors: Roychowdhury Krishanu , Datta Soujanya , Alizadeh Mohammadmahdi , El-Ganainy Ramy 
Published: May 2024

Abstract

In recent years, leveraging principles from condensed matter and high-energy physics has significantly advanced the engineering of laser systems. Chief among these concepts are topology, which enables the construction of robust zero-mode laser devices, and supersymmetry (SUSY), which holds the potential for achieving phase locking in laser arrays. In this work, we show that the relation between supersymmetric coupled bosonic and fermionic oscillators on one side, and bipartite networks (and hence chiral symmetry) on another side can be exploited together with non-Hermitian engineering for building one- and two-dimensional laser arrays with in-phase synchronization. To demonstrate our strategy, we present a concrete design starting from the celebrated Su-Schieffer-Heeger (SSH) model to arrive at a new SUSY laser structure that enjoys two key advantages over those reported in previous works, namely that the design parameters of the laser and reservoir feature near-uniform arrays which are of great importance for practical implementation, and a two-fold far-field intensity scaling. Not only do our results present a unification for the otherwise two distinct physical concepts of topology and SUSY, but also provide a roadmap for pushing the frontier of SUSY laser arrays beyond the proof-of-concept phase.