bluuebunny/crossref_metadata_2025_split huggingface dataset:
Anti-inflammatory Effects of Bacteroidota Strains Derived From Outstanding Donors of Fecal Microbiota Transplantation for the Treatment of Ulcerative Colitis
Authors: Ishikawa Dai , Zhang Xiaochen , Nomura Kei , Shibuya Tomoyoshi , Hojo Mariko , Yamashita Makoto , Koizumi Satoshi , Yamazaki Fuhito , Iwamoto Susumu , Saito Masato , Kunigo Keisuke , Nakano Ryosuke , Honma Nakayuki , Urakawa Itaru , Nagahara Akihito 
Published: May 2024

Abstract

Background
The proportion of certain Bacteroidota species decreased in patients with ulcerative colitis, and the recovery of Bacteroidota is associated with the efficacy of fecal microbiota transplantation therapy. We hypothesized that certain Bacteroidota may advance ulcerative colitis treatment. Accordingly, we aimed to evaluate the anti-inflammatory effects of Bacteroidota strains isolated from donors.

Methods
Donors with proven efficacy of fecal microbiota transplantation for ulcerative colitis were selected, and Bacteroidota strains were isolated from their stools. The immune function of Bacteroidota isolates was evaluated through in vitro and in vivo studies.

Results
Twenty-four Bacteroidota strains were isolated and identified. Using an in vitro interleukin (IL)-10 induction assay, we identified 4 Bacteroidota strains with remarkable IL-10-induction activity. Of these, an Alistipes putredinis strain exhibited anti-inflammatory effects in a mouse model of colitis induced by sodium dextran sulfate and oxazolone. However, 16S rRNA gene-based sequencing analysis of A. putredinis cultures in the in vivo study revealed unexpected Veillonella strain contamination. A second in vitro study confirmed that the coculture exhibited an even more potent IL-10-inducing activity. Furthermore, the production of A. putredinis–induced IL-10 was likely mediated via toll-like receptor 2 signaling.

Conclusions
This study demonstrated that A. putredinis, a representative Bacteroidota species, exhibits anti-inflammatory effects in vivo and in vitro; however, the effects of other Bacteroidota species remain unexplored. Our fecal microbiota transplantation-based reverse translation approach using promising bacterial species may represent a breakthrough in microbiome drug development for controlling dysbiosis during ulcerative colitis.
Answering the key stakeholder questions about the impact of offshore wind farms on marine life using hypothesis testing to inform targeted monitoring
Authors: Cresci Alessandro , Degraer Steven , Zhang Guosong , Dannheim Jennifer , Browman Howard I 
Published: May 2024

Abstract
Stakeholders need scientific advice on the environmental impacts of offshore wind (OW) before the facilities are installed. The utility of conventional environmental monitoring methods as a basis for forecasting OW impacts is limited because they do not explain the causes of the observed effects. We propose a multistep approach, based on process-oriented hypothesis testing, targeted monitoring and numerical modeling, to answer key stakeholder questions about planning an OW facility: Q1—Where do we place future OW farms so that impacts on the ecosystem are minimized? Q2—Which species and ecosystem processes will be impacted and to what degree? Q3—Can we mitigate impacts and, if so, how? and Q4—What are the risks of placing an OW facility in one location vs. another? Hypothesis testing can be used to assess impacts of OW facilities on target species-ecological process. This knowledge is transferable and is broadly applicable, a priori, to assess suitable locations for OW (Q1). Hypothesis testing can be combined with monitoring methods to guide targeted monitoring. The knowledge generated can identify the species/habitats at risk (Q2), help selecting/developing mitigation measures (Q3), and be used as input parameters for models to forecast OW impacts at a large spatial scale (Q1; Q4).
Obesity, beverage consumption and sleep patterns in rural African women in relation to advertising of these beverages
Authors: Phaswana Merling , Mchiza Zandile June-Rose , Onagbiye Sunday Olawale , Gradidge Philippe Jean-Luc 
Published: May 2024

Abstract

Background
The burden of obesity-related, non-communicable diseases in South Africa is persistent, with poor and black South African women particularly vulnerable. The purpose of the present study was to determine relationships between obesity, physical activity, sleep patterns and beverage consumption among black South African women in a rural village in the Limpopo province.

Methods
A cross-sectional study was conducted among 200 rural-dwelling African women. Data were collected on beverage consumption, sociodemographic information, sleep patterns and anthropometry using self-reported questionnaires.

Results
The mean body mass index (BMI) was 28.5±7.3 kg/m2, with 40% being classified as obese (BMI ≥30 kg/m2) and the mean sleep score was 4.68±2.51. Participants with very bad habitual sleeping patterns consumed significantly more sugar-sweetened beverages and alcohol than those with very good sleeping patterns. We also observed that when total coffee with sugar, fruit juice, total sugar-sweetened beverages and weight decreased the number of hours participants slept increased.

Conclusions
The study identified significant associations between body weight, sleep duration and sugar-sweetened beverage consumption among rural black South African women. This underscores a need to address unhealthy lifestyle behaviours to lower incidences of non-communicable diseases in rural-dwelling women.
Integrating clinical research into electronic health record workflows to support a learning health system
Authors: Goldhaber Nicole H , Jacobs Marni B , Laurent Louise C , Knight Rob , Zhu Wenhong , Pham Dean , Tran Allen , Patel Sandip P , Hogarth Michael , Longhurst Christopher A 
Published: May 2024

Abstract

Objective
Integrating clinical research into routine clinical care workflows within electronic health record systems (EHRs) can be challenging, expensive, and labor-intensive. This case study presents a large-scale clinical research project conducted entirely within a commercial EHR during the COVID-19 pandemic.

Case Report
The UCSD and UCSDH COVID-19 NeutraliZing Antibody Project (ZAP) aimed to evaluate antibody levels to SARS-CoV-2 virus in a large population at an academic medical center and examine the association between antibody levels and subsequent infection diagnosis.

Results
The project rapidly and successfully enrolled and consented over 2000 participants, integrating the research trial with standing COVID-19 testing operations, staff, lab, and mobile applications. EHR-integration increased enrollment, ease of scheduling, survey distribution, and return of research results at a low cost by utilizing existing resources.

Conclusion
The case study highlights the potential benefits of EHR-integrated clinical research, expanding their reach across multiple health systems and facilitating rapid learning during a global health crisis.
Effects of porcine somatotropin administration on the responses to dietary lysine and a near-ideal blend of amino acids on the amino acid composition of whole-body protein and amino acid accretion rate in growing pigs
Authors: Dozier William A , Cromwell Gary L , Lewis Austin J , Miller Phillip , Lindemann Merlin D 
Published: May 2024

Abstract
An experiment was conducted to assess the effects of porcine somatotropin (pST) on the responses to a near-ideal blend of AA on the AA composition of empty, whole-empty body (WEB) protein and WEB essential AA accretion rate in pigs from 22 to 60 kg BW. Forty Hampshire × Yorkshire gilts were individually penned and assigned to a 4 × 2 factorial arrangement of treatments consisting of four diets with and without pST injection. A fortified corn–soybean meal basal diet was formulated to contain 1.50% total Lys with Thr, Met, and Trp added to obtain a near-ideal blend of these AA relative to Lys. In three additional diets, Lys was reduced to 1.25%, 1.00%, and 0.75% by diluting the basal diet with cornstarch, cellulose, and sand such that the diets also contained the same ratios of AA. Pigs that received pST were administered a daily i.m. injection of 2 mg of pST. At 60 kg BW, the WEB (carcass, head, viscera, blood, nails, and hair) was ground and analyzed for proximate and AA composition. Administration of pST increased (P &lt; 0.001) accretion rates of WEB protein and essential AA. Increasing dietary essential AA increased (quadratic, P &lt; 0.03) accretion rate of WEB protein, His, Leu, Trp, and Val in pST-treated pigs, but not in untreated pigs. Lysine composition in the accreted WEB protein was not affected (P &gt; 0.05) by dietary Lys. The efficiency of Lys utilization for WEB Lys accretion was linearly affected (P &lt; 0.01) by dietary Lys. These results indicated that the dietary Lys needed to achieve maximum WEB Lys accretion is markedly increased by pST administration.
Pseudocalcifications: Radiologic-Pathologic Correlation of Postsurgical Gauze Artifacts
Authors: Lehrer Daniel , Kaplan Mariela , Ugalde Cecilia , Señuk Valeria , Mosto Julian 
Published: May 2024

Abstract
Artifacts and foreign bodies can mimic microcalcifications. We report a series of 17 postsurgical women in whom mammograms showed fine linear radiodensities at the surgical bed. Vacuum-assisted biopsy histopathology of one of the lesions showed foreign bodies of different sizes with macrophage reaction. After discussion with the surgeons, we ascertained that a particular type of gauze was used that had fragmented, and we reproduced the mammographic appearance in a chicken breast. Furthermore, we showed the same pathology was reproduced in mice implanted with the gauze threads. It is important to be aware of this entity to avoid unnecessary examinations and even biopsy. The presence of foreign body linear gauze fragments at the surgical site can pose challenges in the mammographic follow-up of these patients.
Acute toxicity effects of pesticides on predatory snout mites (Trombidiformes: Bdellidae)
Authors: Knapp Rosemary A , Mata Luis , McDougall Robert , Yang Qiong , Hoffmann Ary A , Umina Paul A 
Published: May 2024

Abstract
Predatory mites biologically control a range of arthropod crop pests and are often central to agricultural IPM strategies globally. Conflict between chemical and biological pest control has prompted increasing interest in selective pesticides with fewer off-target impacts on beneficial invertebrates, including predatory mites. However, the range of predatory mite species included in standardized pesticide toxicity assessments does not match the diversity of naturally occurring species contributing to biocontrol, with most testing carried out on species from the family Phytoseiidae (Mesostigmata). Here, we aim to bridge this knowledge gap by investigating the impacts of 22 agricultural pesticides on the predatory snout mite, Odontoscirus lapidaria (Kramer) (Trombidiformes: Bdellidae). Using internationally standardized testing methodologies, we identified several active ingredients with minimal impact on O. lapidaria mortality, including Bacillus thuringiensis, nuclear polyhedrosis virus, flonicamid, afidopyropen, chlorantraniliprole, and cyantraniliprole, which may therefore be good candidates for IPM strategies utilizing both chemical and biological control. Comparison of our findings with previous studies on Phytoseiid mites reveals important differences in responses to a number of chemicals between predatory mite families, including the miticides diafenthiuron and abamectin, highlighting the risk of making family-level generalizations from acute toxicity assessments. We also tested the impacts of several pesticides on a second Bdellidae species (Trombidiformes: Bdellidae) and found differences in the response to chlorpyrifos compared with O. lapidaria, further highlighting the taxon-specific nature of nontarget toxicity effects.
Behavioral variation among Fox Squirrel (Sciurus niger) populations in urban environments
Authors: Devitz Amy-Charlotte , Dantzer Ben 
Published: May 2024

Abstract
Urbanization presents a myriad of challenges to wildlife, yet some individuals or species persist and even thrive in urban environments. Specific behavioral traits that have been proposed to enable animals to cope with challenges and frequently observed in urban wildlife populations across many taxonomic groups include changes in docility, activity, boldness, sociability, and aggression. We conducted a series of standardized behavioral assays to test the hypothesis that urbanization favors these traits in fox squirrels (Sciurus niger), a species that is widespread in urban areas. Based upon previous studies, we predicted that squirrels would exhibit higher levels of boldness, activity, and aggression and lower docility in urban areas with higher human density compared to their counterparts in areas with lower human density areas. We instead found a trend of higher sociability—but not aggression—in squirrels at higher human density sites over lower human density sites, and no differences in docility, boldness, or activity. Our results indicate that the behavior of fox squirrels does not vary dramatically on a fine scale of human density, apart from a trend in heightened sociability in higher human density urban environments.
Large-scale overlap and fine-scale avoidance: assessing interactions between coyotes, bobcats, and cougars at multiple scales
Authors: Jensen Rylee , Ruprecht Joel , Orning Elizabeth , Levi Taal , Clark Darren E , Forrester Tavis D 
Published: May 2024

Abstract
In multi-carnivore systems individuals must forage and reproduce while also competing with other carnivores and avoiding intraguild predation. These interactions may vary by strength and scales across different ecosystems. We used occupancy analyses and attraction–avoidance indices to assess large- and fine-scale interactions, respectively, between Cougars (Puma concolor), Bobcats (Lynx rufus), and Coyotes (Canis latrans) in northeast Oregon based on data from camera traps set during the summer and fall of 2016 and 2017. To determine the importance of habitat preferences and spatial overlap, we compared occupancy (probability of use) models that included habitat covariates with and without species co-occurrence terms. Detection was different for all species and was influenced by roads, game trails, and canopy cover. Terrain ruggedness was important for all species; Bobcats showed the strongest preference for ruggedness, Cougars showed a weak preference, and Coyotes significantly but weakly avoided rugged areas. The top probability of use model showed that Bobcats and Coyotes were 1.88 times more likely to spatially overlap on roads. We also found evidence that interactions among carnivores were scale-dependent. At larger scales, habitat preference was more important than interactions with other carnivores, whereas at finer scales, most carnivores avoided each other. At fine spatiotemporal scales, our attraction–avoidance analyses showed that Bobcats avoided Coyotes and Coyotes avoided both Bobcats and Cougars. These findings suggest that carnivores in our study system were adept at minimizing conflict through fine-scale avoidance in space and time, that the human footprint can influence carnivore interactions, and that studying carnivore interactions at multiple scales is important for understanding the effects of spatial overlap and potential competition.
H i discs of L* galaxies as probes of the baryonic physics of galaxy evolution
Authors: Gensior Jindra , Feldmann Robert , Reina-Campos Marta , Trujillo-Gomez Sebastian , Mayer Lucio , Keller Benjamin W , Wetzel Andrew , Kruijssen J M Diederik , Hopkins Philip F , Moreno Jorge 
Published: May 2024

ABSTRACT
Understanding what shapes the cold gas component of galaxies, which both provides the fuel for star formation and is strongly affected by the subsequent stellar feedback, is a crucial step towards a better understanding of galaxy evolution. Here, we analyse the H i properties of a sample of 46 Milky Way halo-mass galaxies, drawn from cosmological simulations (EMP-Pathfinder and Firebox). This set of simulations comprises galaxies evolved self-consistently across cosmic time with different baryonic sub-grid physics: three different star formation models [constant star formation efficiency (SFE) with different star formation eligibility criteria, and an environmentally dependent, turbulence-based SFE] and two different feedback prescriptions, where only one sub-sample includes early stellar feedback. We use these simulations to assess the impact of different baryonic physics on the H i content of galaxies. We find that the galaxy-wide H i properties agree with each other and with observations. However, differences appear for small-scale properties. The thin H i discs observed in the local universe are only reproduced with a turbulence-dependent SFE and/or early stellar feedback. Furthermore, we find that the morphology of H i discs is particularly sensitive to the different physics models: galaxies simulated with a turbulence-based SFE have discs that are smoother and more rotationally symmetric, compared to those simulated with a constant SFE; galaxies simulated with early stellar feedback have more regular discs than supernova-feedback-only galaxies. We find that the rotational asymmetry of the H i discs depends most strongly on the underlying physics model, making this a promising observable for understanding the physics responsible for shaping the interstellar medium of galaxies.
STING agonist-conjugated metal-organic framework induces artificial leukocytoid structures and immune hotspots for systemic antitumor responses
Authors: Luo Taokun , Jiang Xiaomin , Fan Yingjie , Yuan Eric , Li Jinhong , Tillman Langston , Lin Wenbin 
Published: May 2024

ABSTRACT
Radiotherapy is widely used for cancer treatment, but its clinical utility is limited by radioresistance and its inability to target metastases. Nanoscale metal-organic frameworks (MOFs) have shown promise as high-Z nanoradiosensitizers to enhance radiotherapy and induce immunostimulatory regulation of the tumor microenvironment. We hypothesized that MOFs could deliver small-molecule therapeutics to synergize with radiotherapy for enhanced antitumor efficacy. Herein, we develop a robust nanoradiosensitizer, GA-MOF, by conjugating a STING agonist, 2′,3′-cyclic guanosine monophosphate–adenosine monophosphate (GA), on MOFs for synergistic radiosensitization and STING activation. GA-MOF demonstrated strong anticancer efficacy by forming immune-cell-rich nodules (artificial leukocytoid structures) and transforming them into immunostimulatory hotspots with radiotherapy. Further combination with an immune checkpoint blockade suppressed distant tumors through systemic immune activation. Our work not only demonstrates the potent radiosensitization of GA-MOF, but also provides detailed mechanisms regarding MOF distribution, immune regulatory pathways and long-term immune effects.
The priority of intentional action: From developmental to conceptual priority
Authors: Levy Yair 
Published: May 2024

Abstract
Philosophical orthodoxy has it that intentional action consists in one's intention appropriately causing a motion of one's body, placing the latter (conceptually and/or metaphysically) prior to the former. Here, I argue that this standard schema should be reversed: acting intentionally is at least conceptually prior to intending. The argument is modelled on a Williamsonian argument for the priority of knowledge developed by Jenifer Nagel. She argues that children acquire the concept KNOWS before they acquire BELIEVES, building on this alleged developmental priority of knowledge to establish its conceptual priority. I start by taking a closer look at Nagel's argument, canvassing extant objections todo both with the empirical adequacy of her claims and their philosophical implications. Doing so allows me, in the second part of the paper, to draw lessons that inform the construction of a revamped parallel argument for the priority of ACTS INTENTIONALLY.
Development of a Method to Measure Trace Levels of Uranium and Thorium in Scintillation Films
Authors: Ichimura K , Chiba K , Gando Y , Ikeda H , Kishimoto Y , Kurasawa M , Nemoto K , Sakaguchi A , Takaku Y , Sakakieda Y 
Published: May 2024

Abstract
We have established a method to measure picograms-per-gram (pg g−1) levels of 238U and 232Th in scintillation films by combining the dry ashing method and inductively coupled plasma mass spectrometry. Trace amounts of 238U and 232Th were measured in up to 2 g of scintillation film with almost 100% collection efficiency. This paper details the experimental procedure, including the pretreatment of the samples and labware, detection limit of the method, collection efficiencies of 238U and 232Th, and measurement of 238U and 232Th in a polyethylene naphthalate film. This method is also applicable to 238U and 232Th measurements in other low-background organic materials for rare-event search experiments.
The View from Above and Below: Subjective Mobility and Explanations of Class, Race, and Gender Inequality
Authors: Hiltner Sofia , Cech Erin A 
Published: May 2024

Abstract
Popular explanations of inequality as the result of individual failings rather than structural processes are powerful cultural mechanisms that legitimize and reproduce inequality in the United States. How might individuals’ experiences of downward or upward mobility shape the explanations they give? We argue that perceived experiences of economic mobility may not only shape how Americans understand economic inequality but may also impact their beliefs about social inequalities more broadly. Using proportionally representative survey data of 1110 U.S. residents, we find that those who perceive that they currently occupy a lower economic class than when they were growing up (i.e., they experienced subjective downward mobility) were more likely than class-stable individuals to reject individualistic explanations of economic inequality and embrace structural ones. By contrast, the upwardly mobile were more likely to reject structural explanations. We find that mobility is similarly related to the likelihood of giving individualistic or structural explanations for race and gender inequality as well. Downward mobility is also associated with greater support of redistributive policies related to economic as well as gender and race inequality. These findings suggest that economic mobility may influence popular explanations of inequality and support for redistributive policy not only related to class inequality but for multiple axes of inequality.