bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hybrid Clot Histomic–Transcriptomic Models Predict Functional Outcome After Mechanical Thrombectomy in Acute Ischemic Stroke
Authors: Santo Briana A. , Poppenberg Kerry E. , Ciecierska Shiau-Sing K. , Baig Ammad A. , Raygor Kunal P. , Patel Tatsat R. , Shah Munjal , Levy Elad I. , Siddiqui Adnan H. , Tutino Vincent M. 
Published: May 2024

BACKGROUND AND OBJECTIVES:
Histologic and transcriptomic analyses of retrieved stroke clots have identified features associated with patient outcomes. Previous studies have demonstrated the predictive capacity of histology or expression features in isolation. Few studies, however, have investigated how paired histologic image features and expression patterns from the retrieved clots can improve understanding of clot pathobiology and our ability to predict long-term prognosis. We hypothesized that computational models trained using clot histomics and mRNA expression can predict early neurological improvement (ENI) and 90-day functional outcome (modified Rankin Scale Score, mRS) better than models developed using histological composition or expression data alone.

METHODS:
We performed paired histological and transcriptomic analysis of 32 stroke clots. ENI was defined as a delta-National Institutes of Health Stroke Score/Scale > 4, and a good long-term outcome was defined as mRS ≤2 at 90 days after procedure. Clots were H&E-stained and whole-slide imaged at 40×. An established digital pathology pipeline was used to extract 237 histomic features and to compute clot percent composition (%Comp). When dichotomized by either the ENI or mRS thresholds, differentially expressed genes were identified as those with absolute fold-change >1.5 and q < 0.05. Machine learning with recursive feature elimination (RFE) was used to select clot features and evaluate computational models for outcome prognostication.

RESULTS:
For ENI, RFE identified 9 optimal histologic and transcriptomic features for the hybrid model, which achieved an accuracy of 90.8% (area under the curve [AUC] = 0.98 ± 0.08) in testing and outperformed models based on histomics (AUC = 0.94 ± 0.09), transcriptomics (AUC = 0.86 ± 0.16), or %Comp (AUC = 0.70 ± 0.15) alone. For mRS, RFE identified 7 optimal histomic and transcriptomic features for the hybrid model. This model achieved an accuracy of 93.7% (AUC = 0.94 ± 0.09) in testing, also outperforming models based on histomics (AUC = 0.90 ± 0.11), transcriptomics (AUC = 0.55 ± 0.27), or %Comp (AUC = 0.58 ± 0.16) alone.

CONCLUSION:
Hybrid models offer improved outcome prognostication for patients with stroke. Identified digital histology and mRNA signatures warrant further investigation as biomarkers of patient functional outcome after thrombectomy.
Fatores clínicos do bem-estar de mulheres em parturição: perspectivas deontológicas e da bioética principialista
Authors: Biondo Chrisne Santana , Anjos Neta Maria Madalena Souza dos , Yarid Sérgio Donha 
Published: May 2024

Objetivo: avaliar os fatores clínicos associados ao bem-estar das mulheres durante o trabalho de parto e parto à luz da bioética principialista e da deontologia. Método: estudo transversal com abordagem quantitativa. Participaram 396 puérperas internadas em um hospital municipal do sudoeste da Bahia, e os dados foram coletados no período de janeiro a maio de 2023, após aprovação do comitê de ética em pesquisa. Os dados foram organizados no software Excel e analisados via SPSS v.25. a partir da regressão logística multinomial. Resultados: a maior parte da amostra apresentou bem-estar com assistência em saúde, mulheres que tiveram parto realizado por profissionais não médicos apresentaram mais chances de níveis de bem-estar “adequado”. E mulheres que não tiveram a via de parto cesárea apresentaram aumento de chances de bem-estar. Conclusão: é necessário que os profissionais reflitam sobre suas ações, condicionando-as à humanização no parto, em observância aos princípios bioéticos.
Feasibility, acceptability, and safety of a novel device for self-collecting capillary blood samples in clinical trials in the context of the pandemic and beyond
Authors: Dasari Harika , Smyrnova Anna , Leng Jing , Ducharme Francine M. 
Published: May 2024

Background
Home blood self-collection devices can enable remote monitoring, but their implementation requires validation. Our objectives were to explore (i) the impact of sampling sites and topical analgesia on capillary blood volume and pain perception and (ii) the safety, acceptability, and failure of capillary self-collection among adults and children using the Tasso-SST device.

Methods
We conducted a two-phase study. The investigational phase consisted of two on-site cross-sectional studies in healthy adult participants (≥ 12 years) and children (1–17 years) with their accompanying parent. Adults received 4 capillary samplings, where puncture sites and topical analgesia were randomized in a factorial design, and a venipuncture; children (and one parent) had one capillary sampling. The two co-primary outcomes were blood volume and pain. The implementation phase was conducted in two multicentre trials in participants choosing remote visits; blood volume, collection failure, adverse events, and satisfaction were documented.

Results
In the investigational phase, 90 participants and 9 children with 7 parents were enrolled; 15 adults and 2 preschoolers participated in the implementation phase. In the adult investigational study, the device collected a median (25%, 75%) of 450 (250, 550) μl of blood with no significant difference between the puncture site, topical analgesia, and its interaction. Using topical analgesia reduced pain perception by 0.61 (95% CI: 0.97, 0.24; P <0.01) points on the 11-point scale; the pain reduction varied by puncture site, with the lower back showing the most significant decrease. Overall, combining all studies and phases, the median volume collected was 425 (250, 500) μl, and the device failure rate was 4.4%; minor adverse effects were reported in 8.9% of the participants, all were willing to use the device again.

Conclusion
Capillary blood self-collection, yielding slightly less than 500 μl, proves to be a safe and relatively painless method for adults and children, with high satisfaction and low failure rates. The puncture site and topical analgesia do not affect blood volume, but topical analgesia on the lower back could reduce pain.
Health risk factors, status and service utilisation of adults in primary health care settings in Qatar: The HEALTHSIGHT study protocol
Authors: Syed Mohamed Ahmed , Hassan Mariam , Veettil Shajitha Thekke , Marji Tamara , Khudadad Hanan , El Kaissi Dana Bilal , Zainel Abduljaleel Abdullatif , Ahmed Mohamed Hafiz , Mathew Bindya , Syed Muslim Abbas , Alnuaimi Ahmed Sameer 
Published: May 2024

Background
The emergence of non-communicable diseases (NCDs) has been well documented in recent literature which constitute a significant global burden of disease. Qatar which has a significantly high prevalence of NCDs with early on set. Epidemiological and health service utilization information plays a central role in facilitating informed decision making and application of the fundamental principles of PHC in planning and delivery of healthcare with aim to prevent and control NCDs. To enable this, the Department of Clinical Research at Primary Health Care Corporation (PHCC), Qatar’s publicly funded and largest primary care provider designed the Health Assessment Linking Trends in Health Status, Risks, and Healthcare Utilization (HEALTHSIGHT) study. This paper describes the HEALTHSIGHT study protocol.

Methods
The proposed study will use a cross sectional study design involving a random sample of participants enrolled across all 31 PHCC health centers. Individuals aged 18 and above years old registered with PHCC and hold a valid health card and contact information on PHCC’s electronic medical records (EMR) will be eligible for inclusion. A stratified random sample not proportional to size sampling technique will be employed to obtain a representative sample size of the PHCC population (N = 6000). Participants will be scheduled for an appointment at a PHCC health centre where a data collector will obtain informed consent, collect vital sign information and administer a questionnaire. A phlebotomist will collect a blood sample. Health service utilization data will be extracted from PHCC’s EMR.

Discussion
Epidemiological and health service utilization information is essential to plan and monitor primary care and public health services. The HEALTHSIGHT study, with the help of a randomly selected representative sample from Qatar’s primary healthcare settings, provides a unique opportunity to capture this information. This study design will closely represent a real-world understanding of the health risk, status and utilisation and is likely to provide important data to guide primary care planning and delivery in Qatar. The proposed protocol provides an example of a robust nationwide study that be undertaken in short duration using limited resource which can be undertaken in other similar settings.
Dye degradation activity of biogenically synthesized Cu/Fe/Ag trimetallic nanoparticles
Authors: Roy Arpita , Kunwar Srijal , Bhusal Utsav , Idris Dahir Sagir , Alghamdi Saad , Chidambaram Kumarappan , Qureshi Absar Ahmed , Qusty Naeem F. , Khan Abduljawad Abdulshakor , Kaur Kirtanjot , Roy Amit 
Published: May 2024

Abstract
Over the past few decades, nanotechnology has gained momentum because of its potential to create a safer and healthier living environment using eco-friendly approaches. This study describes a safer, more dependable, and ecologically friendly technique of biologically synthesizing Cu/Fe/Ag trimetallic nanoparticles (NPs) using an aqueous leaf extract of Catharanthus roseus as the reducing and stabilizing agent. The synthesized trimetallic NPs were characterized by scanning electron microscope, Fourier transform infrared, dynamic light scattering, and ultraviolet–visible analysis and were evaluated for their potential applications, which included antioxidant properties and catalytic dye degradation. The result suggests that the antioxidant properties of Cu/Fe/Ag NPs are more significant than those of ascorbic acid, a known antioxidant, at lower doses (10 µg·ml−1) while a higher dose of 1,000 µg·ml−1 gives a 69.81% scavenging activity. The impact of Cu/Fe/Ag trimetallic NPs on the catalytic degradation of hazardous dyes such as phenol red (PR) and eosin yellow (EY) was also studied in this work. For PR and EY, the corresponding percentages of degradation were 76% and 48.6%, respectively.
Representações do passado colonial para a descolonização da memória: leituras a partir da literatura contemporânea brasileira e alemã
Authors: Calça Elaine 
Published: May 2024

Resumo
Este artigo apresenta resultados preliminares do estudo comparativo de romances históricos contemporâneos sobre o passado colonial. Ao analisar essas novas narrativas, nota-se como elas se diferem da literatura colonial, produzida mundialmente até meados do século XX. Nossa hipótese aponta que, ao trabalhar a falta daquilo que não estava na historiografia, as fontes documentais são usadas como matéria-prima literária e conseguem, em alguma medida, intervir na memória pública sobre o passado colonial no Brasil e na Alemanha, contribuindo para a descolonização dessa memória.
Vorüberlegungen für eine translationsrelevante Klassifikation von Personifizierungen: Sekundäre Subjektivierung und Definitionskollisionen im Bereich Bildhafte Sprache
Authors: Jodl Frank 
Published: May 2024

Abstract
To facilitate idiomaticity, translation practice and translation didactics require that the linguistic phenomenon of personification be handled confidently when translating into German. At first glance, the term personification appears to be well defined. However, on closer inspection it becomes clear that the term is used in different ways by classical rhetoric on the one hand and by linguistics and translation studies on the other. This becomes clear when examining the phenomenon of secondary subjectification, which a) causes problems of idiomaticity and b) is often – wrongly – seen as synonymous with personification. The manuals of classical rhetoric, despite being generally consulted first by researchers, do not consider secondary subjectification and thus do not provide a complete view of the concept of personification. In order to describe the problem more precisely, the present paper will go beyond purely stylistic-idiomatic concerns by taking into account the functional side of figurative language. This involves emphasizing that not every personification is automatically a secondary subjectification. In German, however, secondary subjectifications can have the same effect as personifications, which can cause problems of idiomaticity. In order to provide some clarification, we suggest establishing a specific classification of personifications for translational purposes.
Kurpian glides
Authors: Rubach Jerzy 
Published: May 2024

Abstract
This article addresses the problem of vowel-generated glides in Kurpian. In general, glides come from two sources: Gliding and Glide Insertion, for instance, word-initial /#iVC/ → [jVC] and /#iC/ → [jiC], where V stands for a vowel and C for a consonant. Even though Gliding and Glide Insertion are different phonological operations, they are united by a single goal: to eliminate onsetless syllables because a glide, regardless of whether it comes from a vowel or from insertion, provides an onset to a syllable. Onset-driven effects are particularly rich in Kurpian because they involve all kinds of vowels, including /a/ but not /ɛ/, a situation that has not been noted in the past research on crosslinguistic typologies (Levi, Susannah V. 2004. The representation of underlying glides: A cross-linguistic study. Seattle, WA: University of Washington dissertation, Levi, Susannah V. 2008. Phonemic vs. derived glides. Lingua 118. 1956–1978; Rosenthall, Sam. 1994. Vowel/glide alternation in a theory of constraint interaction. Amherst, MA: University of Massachusetts dissertation; Sands, Kathy. 2004. Patternings of vocalic sequences in the world’s languages. Santa Barbara, CA: University of California, Santa Barbra dissertation). Further, glides are found both word-medially and word-initially. In this regard, Kurpian is different from Standard Polish, which tolerates both hiatus and word-initial onsetless syllables. It is argued that the constraint interaction required cannot be accounted for in classic Optimality Theory (OT). The solution is to adopt Derivational OT.
Verborgene Gegenwart
Authors: Koenig Katrin 
Published: May 2024

Zusammenfassung
Wie kann Gottes Gegenwart trotz ihrer Verborgenheit wahrgenommen werden? In dem folgenden Beitrag möchte ich zeigen, wie Simone Weil die Erfahrungen der Verborgenheit und der Abwesenheit Gottes als Signatur des Unglücks und der Entwurzelung der Menschen in der Moderne analysiert. Des Weiteren wird dargestellt, wie Simone Weil vor diesem Hintergrund mit einer kreuzestheologischen Denkfigur reflektiert, wie die Gottesliebe in besonderer Weise im Unglück verborgen anwesend sein kann, trotz Erfahrung der Abwesenheit Gottes. Hier schließt sich die erkenntnistheoretische Frage nach der Wahrnehmbarkeit der verborgenen Gegenwart Gottes an. So soll ausgeführt werden, wie Simone Weil aufzeigt, wie durch ästhetische Formen der Schönheit und Ordnung der Welt, durch ethische Formen von Nächstenliebe und Freundschaft und durch die religiöse Formen in Liturgie und Gebet als höchster Form der Aufmerksamkeit die verborgen gegenwärtige Gottesliebe indirekt wahrgenommen werden kann. Dies spricht schließlich für eine andere Deutung der Verborgenheit Gottes als im sog. Verborgenheitsargument von J. L. Schellenberg, mit dem von der Verborgenheit auf die Nichtexistenz Gottes geschlossen wird.
AI-Powered Augmented Reality App Satisfies My Beauty Needs and Want
Authors: Butt Asad Hassan , Ahmad Hassan , Khan Naeem , Mumtaz Usman , Muzaffar Asif 
Published: May 2024

Abstract
Purpose: Online shopping is changing because of augmented reality technology. The study aimed to understand augmented reality’s impact on the consumer shopping experience in an online context and further understand how its information, service, and ease of use can impact its continuous intention. Design/Methodology/approach: This research is based on a sample of 348 from China and structural equation modeling using Smart-PLS. Findings: The study outcomes show that Chinese consumers are intrigued and feel engaged with the augmented reality makeup app. Most users have shown positive results towards different constructs, which shows the significance of this technology. Chinese consumers adopt such technologies because of their immersive power that enhances the real environment while shopping online for cosmetic products. Originality: Augmented reality is a disruptive technology that is changing the shopping experience. The current framework helps to understand consumer engagement with this technology and contributes to the AR literature and theory. The insights provide a strong base for future strategy development to integrate this technology in online and offline stores.
Study on electrical conductive mechanism of mayenite derivative C12A7:C
Authors: Ji Cong , Yang Shan-shan , Gu Fan 
Published: May 2024

Abstract
This study explains the conductive mechanism of C12A7:C from the perspective of crystal structure. C12A7:C is a carbon derivative of C12A7 and prepared by CaCO3 and Al2O3 in sealed graphite crucible through high-temperature sintering experiments. The main component was confirmed to be C12A7:C through X-ray diffraction inversion analysis. The four-probe method revealed that it is a semiconductor with conductivity of 4,339 S/m. A conductive model of C12A7:C crystal was established to study its conductive mechanism. Through theoretical calculations of the conductive structure model, the density of states and transfer function are important factors determining the conductivity of C12A7:C crystals. Based on the analysis of these two factors, C is the key to electron transfer in the C12A7:C crystal. Further research indicates that the C–C bond is the main form of C in C12A7:C crystals. These C–C bonds satisfy the formation conditions of conjugated systems and are key to the conductivity of C12A7:C crystals. Through simulation calculations, the volt ampere characteristic curve of C12A7:C exhibits Ohmic conductor characteristics. The conductivity of C12A7:C obtained through theoretical calculation is consistent with the experimental results. In conclusion, the conductivity of C12A7:C crystal is mainly due to the C–C conjugated system formed by carbon atoms in the crystal.
4-h mean lactate clearance as a good predictor of adverse outcome in acute cardiogenic pulmonary edema: a pilot study
Authors: Vural Abdussamed , Karapehlivan Mahmut , Dolanbay Turgut , Cumaoglu Mustafa Oguz , Hatip Ahmet Yunus , Cetinkaya Yakup , Unalan Adnan 
Published: May 2024

Abstract

Objectives
This pilot study aimed to evaluate the efficacy of the 4-h mean lactate clearance (LACclr) level as a predictive factor for in-hospital outcomes, 30-day mortality, and treatment success in patients with acute cardiogenic pulmonary edema (ACPE), a significant clinical form of acute heart failure (AHF).

Methods
A total of 44 patients diagnosed with acute pulmonary edema were included in the study. The patients were divided into two groups based on lactate levels and negative outcomes, and lactate and LACclr levels and negative outcomes were analyzed using statistical tests such as Fisher’s exact test, Student’s t-test, Mann-Whitney U test, and Receiver operating characteristic (ROC) analysis.

Results
The results indicated a statistically significant difference in the total hospitalization length of stay according to whether the patients had a negative outcome (intubation and in-hospital mortality) (p=0.033). Additionally, the area under the curve (AUC) value for 4-h mean LACclr was 0.795 in all patients, which was statistically significant in predicting 30-day mortality (p=0.033). The optimal cut-off value for the 4-h mean LACclr in predicting 30-day mortality was found to be 5.57 %, with 80 % sensitivity and 66.7 % specificity. The threshold to rule out 30-day mortality for all patients was 18.85 with 100 % sensitivity and 30.2 % specificity (AUC, 0.795 95 % CI [0.546–1.000], p=0.033).

Conclusions
These findings suggest that the 4-h LACclr level, calculated within 4 h of emergency department (ED) presentation, can be used as a predictive indicator for needing intubation, in-hospital mortality, and 30-day mortality and to identify patients at higher risk for adverse outcomes.
Whose Security? Conflict and (Critical) Security Studies in the Middle East and North Africa
Authors: Abboud Samer 
Published: May 2024

Security Studies (SS) is a subfield of International Relations (IR) concerned with the ways that conflict and violence contribute to shaping the world. The subfield’s concern with the conditions of war and peace has situated the state as the referent object of security and produced a state-centrism in scholarship, academic journals, and teaching that overemphasizes security as a policy problem. Beginning in the early 1990s challenges to state-centrism emerged through Human Security (HS) and Critical Security Studies (CSS) approaches that sought to challenge and rethink the referent objects of security while introducing more critical theoretical traditions from which to research, publish, and teach about what constitutes threat and security. These new approaches expanded inquiry into security and oriented scholars around different ways of approaching questions of what security is and for whom (or what) it is produced. Despite the expansion of the different subfields of inquiry into security, a common criticism levelled at these approaches concerned how regions of the Global South were incorporated into scholarship.
In this reflective essay, I draw inspiration from these criticisms to ask how the Middle East and North Africa (MENA) has been studied, taught, and theorized from in the fields of Security Studies and Critical Security Studies. The principal question guiding this essay is What do different traditions in Security Studies have to tell us about conflict in the Middle East and North Africa? I seek to reflect on how the region, its peoples, and their experiences are incorporated into these fields and how this has shaped scholarly and popular understandings of conflict and peace in the MENA. I wish to reflect on how tensions between the MENA’s incorporation into SS and CSS produce patterns of visibility and invisibility. I then shift attention to a discussion of how the emergent scholarship on non-Western IR and other approaches from within the MENA region itself may contribute to different ways of researching and teaching conflict and security in the MENA. The essay concludes with some observations about the future of conflict and security studies in the MENA with an emphasis on key questions that are raised in the context of the region’s contemporary overlapping crises.