bluuebunny/crossref_metadata_2025_split huggingface dataset:
Middle-ear endoscopy and trans-tympanic drug delivery using an interventional sialendoscope: feasibility study in human cadaveric temporal bones
Authors: Peters G , Lin J , Arriaga M A , Nuss D W , Schaitkin B , Walvekar R R 
Published: June 2010

AbstractObjective:This study aimed to assess the feasibility of using a 1.3 mm, semi-rigid, interventional salivary endoscope for middle-ear endoscopy, and as a trans-tympanic route for delivery of medication, in human cadaveric temporal bones.Study design:Human cadaveric study.Methods:Five temporal bones harvested from human cadavers were examined. A 1.3 mm, interventional sialendoscope was used to make endoscopy-assisted myringotomy incisions in the postero-inferior quadrant (n = 5) and the antero-inferior quadrant (n = 3).Results:Middle-ear examination was successful in all specimens (n = 5). Access to the round window niche and adequate visualisation of the round window were achieved in all five temporal bones (100 per cent). A guide wire could be navigated to the round window niche without difficulty. Other structures identified in all specimens included the incudostapedial joint, stapedius tendon, pyramidal eminence and facial nerve via an extended myringotomy incision. The anterior middle-ear space was also successfully examined through an endoscope-guided anterior myringotomy. The opening to the eustachian tube was visualised and cannulated with a guide wire in all preparations in which this was attempted (n = 3).Conclusions:The 1.3 mm, interventional sialendoscope allowed adequate visualisation of the eustachian tube, middle-ear space and round window niche, with interventional capabilities, in a cadaveric model. Our result validates the feasibility of its use for trans-tympanic drug delivery.
Patients' perceptions of doctors' clothing: should we really be ‘bare below the elbow’?
Authors: Bond L , Clamp P J , Gray K , Van Dam V 
Published: June 2010

AbstractIntroduction:In September 2007, the Department of Health published Uniforms and Workwear: an Evidence Base for Guiding Local Policy. Following this, most National Health Service trusts imposed a ‘bare below the elbow’ dress code policy, with clinical staff asked to remove ties, wristwatches and hand jewellery and to wear short-sleeved tops. There is currently no evidence linking dress code to the transmission of hospital-acquired infection. We designed the current survey to assess patients' perceptions of doctors' appearance, with specific reference to the ‘bare below the elbow’ policy.Materials and methods:A questionnaire showing photographs of a doctor in three different types of attire (‘scrubs’, formal attire and ‘bare below the elbow’) were used to gather responses from 80 in-patients and 80 out-patients in the ENT department. Patients were asked which outfit they felt was the most hygienic, the most professional and the easiest identification of the person as a doctor. They were also asked to indicate their overall preference.Results and analysis:Formal attire was considered most professional and the easiest identification that the person was a doctor. Scrubs were considered most hygienic. Respondents' overall preference was divided between scrubs and formal clothes. ‘Bare below the elbow’ attire received the lowest votes in all categories.Discussion:This finding raises significant questions about the Department of Health policy in question. The authors suggest that an alternative policy should be considered, with scrubs worn for in-patient situations and formal attire during out-patient encounters.
Vestibular evoked myogenic potentials: review
Authors: Mudduwa R , Kara N , Whelan D , Banerjee Anirvan 
Published: June 2010

AbstractBackground:Disorders of balance often pose a diagnostic conundrum for clinicians, and a multitude of investigations have emerged over the years. Vestibular evoked myogenic potential testing is a diagnostic tool which can be used to assess vestibular function. Over recent years, extensive study has begun to establish a broader clinical role for vestibular evoked myogenic potential testing.Objectives:To provide an overview of vestibular evoked myogenic potential testing, and to present the evidence for its clinical application.Review type:Structured literature search according to evidence-based medicine guidelines, performed between November 2008 and April 2009. No restrictions were applied to the dates searched.Conclusion:The benefits of vestibular evoked myogenic potential testing have already been established as regards the diagnosis and monitoring of several clinical conditions. Researchers continue to delve deeper into potential new clinical applications, with early results suggesting promising future developments.
Encounter rates of cetaceans in the Mediterranean Sea and contiguous Atlantic area
Authors: Boisseau Oliver , Lacey Claire , Lewis Tim , Moscrop Anna , Danbolt Magnus , McLanaghan Richard 
Published: June 2010

A series of visual–acoustic surveys were carried out in the Mediterranean Sea between 2003 and 2007 from RV ‘Song of the Whale’. Almost 21,000 km of trackline were surveyed between the longitudes of 14°W and 36°E with an emphasis on regions with low survey effort. Survey tracklines were designed to provide even coverage probability with random start points. Ten cetacean species were positively identified (sperm whale, fin whale, Cuvier's beaked whale, false killer whale, long-finned pilot whale, Risso's dolphin, common bottlenose dolphin, rough-toothed dolphin, striped dolphin and short-beaked common dolphin). Several of these species, plus sei whale and harbour porpoise, were also encountered in the Atlantic contiguous area (the entrance waters of the Mediterranean between the Iberian Peninsula and north-west Morocco). These surveys expand and clarify the known distributions of cetaceans within the Mediterranean basin. New species documented from Libyan waters include sperm whale, striped dolphin and rough-toothed dolphin. False killer whales and rough-toothed dolphins were documented for the first time off Cyprus. Live harbour porpoises were seen for the first time on Morocco's Atlantic seaboard. It is suggested that the status of rough-toothed dolphins in the Mediterranean be revised from visitor to regular species. Substantial new information on encounter rates is now available for the planning of a basin-wide systematic survey of cetaceans within the Mediterranean Sea and contiguous Atlantic waters.
Studies on reproductive biology and ecology of blue swimming crabPortunus pelagicusfrom Chilika Lagoon, Orissa, India
Authors: Sahoo D. , Panda S. , Guru B.C. 
Published: June 2010

Portunus pelagicusa commercially important crab species found in Chilika lagoon constitutes about 20% of the total crab production. The carapace width (CW) ranges from 4.5–10.5 cm in both the sexes during the study period. The maximum abundance of male was at 6.6 to 7.5 cm CW whereas the females predominate from 6.6 to 9.5 cm CW. The relationship between carapace length (CL) and CW is linear in both sexes which indicates isometric growth. However, the relationship between CL, CW with total body weight (TW) is exponential. The food habit from gut content analysis shows that the species is highly carnivorous and the main food items include prawn carapace and appendages (27.58%), molluscan remaining (21.55%), fish bone (7.75%), seagrass (1.72%), unidentified materials (4.31%) and the mixed food (37.06%). The feeding index was found highest (80.95%) in February whereas it is lowest (60.9%) in June. The mature females are observed from May to July with a peak in July in the lagoon. The highest gonadosomatic index is found in July with an average CW of 10.5 cm. No berried females are found in the study period, which indicates that it did not spawn inside the lagoon and migrates to the sea during the rainy season.
Community structure and biodiversity of shallow water macrobenthic fauna at Noor coast, South Caspian Sea, Iran
Authors: Taheri Mehrshad , Foshtomi Maryam Yazdani 
Published: June 2010

For studying community structure and biodiversity of macrofauna, seasonal samplings were carried out along three different depths (5, 15 and 30 m) in four transects (12 stations) at Noor coast during 2005. Four higher taxa were determined. Polychaeta was the dominant group comprising 96.61 of the total individuals, followed by Bivalvia 1.35%, Oligochaeta 1.15% and Amphipoda 0.87%. Of the six encountered species, the polychaete, Streblospio gynobranchiata accounted for 84.95 of the total population. Also, Tubificoides fraseri was observed in the Caspian Sea for the first time. During this study, density of macrofauna increased with depths, total organic matter and percentage of silt–clay. The highest density was obtained in winter and the lowest was observed in summer. Maximum diversity, richness, and evenness were obtained, 0.91, 1.05 and 0.88, respectively. Also, multivariate analysis separated differences of density between seasons and depths.
Beyond aspect:will be -ingandshall be -ing
Authors: CELLE AGNÈS , SMITH NICHOLAS 
Published: June 2010

This article discusses the synchronic status and diachronic development ofwill be -ingandshall be -ing(as inI'll be leaving at noon).2Although available since at least Middle English, the constructions did not establish a significant foothold in standard English until the twentieth century. Both types are also more prevalent in British English (BrE) than American English (AmE).We argue that in present-day usagewill/shall be -ingare aspectually underspecified: instances that clearly construe a situation as future-in-progress are in the minority. Similarly, although volition-neutrality has been identified as a key feature ofwill/shall be -ing, it is important to take account of other, generally richer meanings and associations, notably ‘future-as-matter-of-course’ (Leech 2004), ‘already-decided future’ (Huddleston & Pullum et al. 2002) and non-agentivity. Like volition-neutrality, these characteristics appear to be relevant not only in contemporary use, but also in their historical expansion. We show that the construction has evolved from progressive aspect towards more subjectivised evidential meaning.
Something fishy? News media presentation of complex health issues related to fish consumption guidelines
Authors: Greiner Amelia , Clegg Smith Katherine , Guallar Eliseo 
Published: June 2010

AbstractObjectiveThe news media are an important source of dietary information. Understanding news content, particularly the portrayal of risks and benefits of certain foods, is relevant for effective public health communication. Fish consumption may reduce risk for CVD and aid neonatal development, but recent work shows public confusion about the benefits of fish, challenged by the evidence of mercury and other contaminants in fish. We present an analysis of the messages about fish in US news media over 15 years, identifying trends in coverage and highlighting implications of current messaging.DesignWe conducted a descriptive text analysis and coded for manifest content: locality of focus, story frame, reference to studies, inclusion of government guidelines and portrayal of uncertainty. We identified chronological patterns and analysed the data for statistically significant relationships between media source and content.SettingNews stories were selected from five daily newspapers and five television networks (1993–2007).SubjectsWe analysed 310 health-related news stories on fish.ResultsRisk messages outweighed benefit messages four to one, and health benefits only became prominent after 2002. No difference existed in coverage topic by news source. Fish consumption has increasingly become a national issue.ConclusionsWith the bulk of messages about fish consumption focused on risk, the benefits may be lost to consumers. This gap creates a need for public health to work with news media to more effectively communicate benefits and risks around fish consumption and health and to consider options for communicating tailored information where it can be more readily utilised.
OPTIMAL EXERCISE PRICE OF AMERICAN OPTIONS NEAR EXPIRY
Authors: CHEN WEN-TING , ZHU SONG-PING 
Published: June 2010

AbstractThis paper investigates American puts on a dividend-paying underlying whose volatility is a function of both time and underlying asset price. The asymptotic behaviour of the critical price near expiry is deduced by means of singular perturbation methods. It turns out that if the underlying dividend is greater than the risk-free interest rate, the behaviour of the critical price is parabolic, otherwise an extra logarithmic factor appears, which is similar to the constant volatility case. The results of this paper complement numerical approaches used to calculate the option values and the optimal exercise price at times that are not close to expiry.
Teaching Legal Research in Canadian Law Schools: Are We Meeting the Needs of the Profession?
Authors: Eaton John 
Published: June 2010

AbstractIn this philosophical article John Eaton from the University of Manitoba recounts the current legal education system in Canada and reflects on the issues involved in teaching legal research skills, including problems with where to base the training within the curriculum, and difficulties encountered in the migration from hard copy research, to current students' predilections for using electronic sources. Whilst based on the Canadian process his article has a wider application in relation to the “Google-generation” of students.
The realities of storing carbon dioxide - A response to CO2 storage capacity issues raised by Ehlig-Economides & Economides
Authors: Chadwick Andy , Smith Dan , Hodrien Chris , Hovorka Sue , Mackay Eric , Mathias Simon , Lovell Bryan , Kalaydjian Francois , Sweeney Graeme , Benson Sally , Dooley Jim , Davidson Casie 
Published: June 2010

AbstractIn a recent publication, Ehlig-Economides & Economides (2010) have sought to demonstrate that carbon dioxide capture and storage (CCS) is not technically or economically feasible, based on a supposed lack of underground storage capacity. We consider this to be a serious misrepresentation of the scientific, engineering and operational facts surrounding CCS. Ehlig-Economides & Economides raise a number of storage related issues: reservoir boundaries, capacity, pressure management, storage integrity, dissolution and storage in depleted reservoirs. We take each one in turn, highlighting specific errors in the paper but also drawing attention to more general background issues. Finally, we discuss in more detail some inconsistencies in the paper surrounding the reservoir engineering calculations.
Glycyrrhetinic acid attenuates vascular smooth muscle vasodilatory function in healthy humans
Authors: Sobieszczyk Piotr , Borlaug Barry A. , Gornik Heather L. , Knauft Wesley D. , Beckman Joshua A. 
Published: June 2010

Abnormal glucocorticoid metabolism contributes to vascular dysfunction and cardiovascular disease. Cortisol activation of vascular mineralocorticoid and glucocorticoid receptors is regulated by two types of 11β-HSD (11-β hydroxysteroid dehydrogenase), namely 11β-HSD2 and 11β-HSD1 (type 2 and type 1 11β-HSD respectively). We hypothesized that inhibition of 11β-HSD would attenuate vascular function in healthy humans. A total of 15 healthy subjects were treated with the selective 11β-HSD inhibitor GA (glycyrrhetinic acid) or matching placebo in a randomized double-blinded cross-over trial. 11β-HSD activity was assessed by the urinary cortisol/cortisone ratio, and vascular function was measured using strain-gauge plethysmography. Endothelial function was measured through incremental brachial artery administration of methacholine (0.3–10 μg/min) and vascular smooth muscle function with incremental verapamil (10–300 μg/min). GA increased the 24-h urinary cortisol/cortisone ratio compared with placebo (P=0.008). GA tended to reduce the FBF (forearm blood flow) response to methacholine (P=0.09) and significantly reduced the FBF response to verapamil compared with placebo (P=0.04). MAP (mean arterial pressure) did not differ between the study conditions. 11β-HSD inhibition attenuated vascular smooth muscle vasodilatory function in healthy humans. Disturbances in cortisol activity resulting from 11β-HSD inactivation is therefore a second plausible mechanism for mineralocorticoid-mediated hypertension in humans.
Woman With Speech Disability Achieves Dream: Goes to College
Authors: Luciani Beth Anne 
Published: June 2010

Abstract
College is the dream of many high school students; however, it poses special challenges for individuals with complex communication needs. In this paper, the author describes her work both while in high school as well as during college in order to promote success in a post-secondary setting. She also describes the importance of a team approach to promoting positive transition outcomes.
Speech and Cognitive-Linguistic Function in Parkinson's Disease
Authors: Spencer Kristie , Sanchez Janelle , McAllen Audra , Weir Phillip 
Published: June 2010

AbstractPurpose: Parkinson's disease is among the most common of the motor-based progressive neurologic disorders. This article provides a review of the motor, cognitive, sensory-perceptual, and linguistic deficits that may occur as a result of the loss of dopaminergic neurons, which causes Parkinson's disease.Method: A review of the literature regarding the nature of Parkinson's disease points out the primary triad of symptoms, which are tremor, rigidity, and bradykinesia. Descriptions of these cardinal symptoms are discussed, as are the non-motor symptoms frequently seen in this disorder, including cognitive changes, sensory-perceptual deficits, and occasionally, linguistic deficits. Dysarthria and dysphagia are frequently seen as a result of the motor deficits associated with Parkinson's disease.Conclusions: Much has been learned about the pathogenesis of Parkinson's disease, which has led to improved pharmacologic, surgical, and behavioral management. Speech-language pathologists (SLPs) need to be aware of these advances in order to better assess and treat patients and educate families.
The Speech-Language Pathologist in the Public Schools: Preparation for Real Life Practices From the Perspective of a Speech-Language Pathology Program Coordinator
Authors: Wenhardt Francine 
Published: June 2010

Abstract
The speech-language pathologist (SLP) working in the public schools has a wide variety of tasks. Educational preparation is not all that is needed to be an effective school-based SLP. As a SLP currently working in the capacity of a program coordinator, the author describes the skills required to fulfill the job requirements and responsibilities of the SLP in the school setting and advises the new graduate regarding the interview process and beginning a career in the public schools.
Ribosome recycling step in yeast cytoplasmic protein synthesis is catalyzed by eEF3 and ATP
Authors: Kurata Shinya , Nielsen Klaus H. , Mitchell Sarah F. , Lorsch Jon R. , Kaji Akira , Kaji Hideko 
Published: June 2010

After each round of protein biosynthesis, the posttermination complex (PoTC) consisting of a ribosome, mRNA, and tRNA must be disassembled into its components for a new round of translation. Here, we show that a
Saccharomyces cerevisiae
model PoTC was disassembled by ATP and eukaryotic elongation factor 3 (eEF3). GTP or ITP functioned with less efficiency and adenosine 5γ′-(β,γ-imido)triphosphate did not function at all. The
k
cat
of eEF3 was 1.12 min
-1
, which is comparable to that of the in vitro initiation step. The disassembly reaction was inhibited by aminoglycosides and cycloheximide. The subunits formed from the yeast model PoTC remained separated under ionic conditions close to those existing in vivo, suggesting that they are ready to enter the initiation process. Based on our experimental techniques used in this paper, the release of mRNA and tRNA and ribosome dissociation took place simultaneously. No 40S•mRNA complex was observed, indicating that eEF3 action promotes ribosome recycling, not reinitiation.
Protection of Telomeres 1 Is Required for Telomere Integrity in the Moss Physcomitrella patens
Authors: Shakirov Eugene V. , Perroud Pierre-François , Nelson Andrew D. , Cannell Maren E. , Quatrano Ralph S. , Shippen Dorothy E. 
Published: June 2010

Abstract
In vertebrates, the single-stranded telomeric DNA binding protein Protection of Telomeres 1 (POT1) shields chromosome ends and prevents them from eliciting a DNA damage response. By contrast, Arabidopsis thaliana encodes two divergent full-length POT1 paralogs that do not exhibit telomeric DNA binding in vitro and have evolved to mediate telomerase regulation instead of chromosome end protection. To further investigate the role of POT1 in plants, we established the moss Physcomitrella patens as a new model for telomere biology and a counterpoint to Arabidopsis. The sequence and architecture of the telomere tract is similar in P. patens and Arabidopsis, but P. patens harbors only a single-copy POT1 gene. Unlike At POT1 proteins, Pp POT1 efficiently bound single-stranded telomeric DNA in vitro. Deletion of the P. patens POT1 gene resulted in the rapid onset of severe developmental defects and sterility. Although telomerase activity levels were unperturbed, telomeres were substantially shortened, harbored extended G-overhangs, and engaged in end-to-end fusions. We conclude that the telomere capping function of POT1 is conserved in early diverging land plants but is subsequently lost in Arabidopsis.
Hand dermatitis/eczema: Current management strategy
Authors: SEHGAL Virendra N. , SRIVASTAVA Govind , AGGARWAL Ashok K. , SHARMA Alpna D. 
Published: June 2010

AbstractEver since its inception a couple of centuries ago, hand dermatitis/eczema has been in the reckoning. Idiosyncrasies continued to loom large thereafter, till it acquired its appropriate position. Dermatitis/eczema are synonymous, often used to indicate a polymorphic pattern of the inflammation of the skin, characterized by pruritus, erythema and vesiculation. A spectrum delineated into acute sub‐acute and chronic dermatitis of the hands. Pompholyx, recurrent focal palmer peeling, ring, wear and tear and fingertip eczema, apron, discoid eczema, chronic acral dermatitis, gut and patchy papulosquamous eczema are its clinical variants. Occupational dermatitis/eczema may be contributory. Etiological definitions are clinched by detailed history of exogenous and endogenous factors. However, scientific confirmation of the entity is through patch testing by using available antigens.
Increased carbonyl protein level in the stratum corneum of inflammatory skin disorders: A non‐invasive approach
Authors: IWAI Ichiro , SHIMADZU Kiyo , KOBAYASHI Yusuke , HIRAO Tetsuji , ETOU Takafumi 
Published: June 2010

AbstractThe stratum corneum (SC) is the interface of body and environment, and is continuously exposed to oxidative stress, resulting in carbonyl modification of proteins. We have developed a simple and non‐invasive method to assess carbonyl protein (CP) level in the SC, applied it to various kinds of skin, and revealed a link between the stratum corneum carbonylated protein (SCCP) level and water content in the SC. The purpose of the present study is to examine the SCCP level in inflammatory skin disorders associated with xerosis. Psoriasis vulgaris (PV) and atopic dermatitis (AD) are typical inflammatory skin disorders, of which the stratum corneum shows markedly low water content. SC samples were non‐invasively collected from the lesional and non‐lesional areas of PV and AD by adhesive tape stripping, and their carbonyl groups were determined by reaction with fluorescein‐5‐thiosemicarbazide. The average fluorescence intensity of the SC was calculated as SCCP level. Higher SCCP level was observed in the lesional area of PV as compared with non‐lesional area or healthy control. Lesional area of AD also exhibited higher SCCP level than corresponding non‐lesional area, of which SCCP level was slightly higher than the healthy control. These data suggest the involvement of oxidative modification of the SC protein, at least in part, in generation of xerotic skin in inflammatory skin disorders as well as dry skin in healthy subjects.