bluuebunny/crossref_metadata_2025_split huggingface dataset:
Recreational fishers' attitudes towards the 2004 rezoning of the Great Barrier Reef Marine Park
Authors: SUTTON STEPHEN G. , TOBIN RENAE C. 
Published: December 2009

SUMMARYWith the marine environment under increasing threat from multiple sources, the ability of managers to generate support from stakeholders will be vital for the success of conservation initiatives. In 2004, a new zoning plan for the Great Barrier Reef Marine Park increased no-take areas from 4.5% to 33% of the total Park area. The aims of this study were to measure recreational fishers' level of support for the plan and understand how they form attitudes towards conservation initiatives in the Park. A survey of Great Barrier Reef Marine Park recreational fishers conducted three years after implementation of the new zoning plan revealed that 68% of fishers believed that, in general, rezoning the Marine Park was a good idea, whereas 57% supported the actual zoning plan that was implemented. A majority of fishers believed that rezoning the Marine Park was necessary, that the new zoning plan had high conservation value, and that the plan had little impact on their recreational fishing activity. However, most fishers had low to moderate satisfaction with the programme used to consult the public throughout the rezoning process. Logistic regression models revealed a strong relationship between level of support for the plan and fishers' perceptions about the necessity of the plan and its conservation value, the adequacy of the consultation process, and the impact of the plan on their fishing activity. Results indicate that recreational fishers can be strong supporters of conservation initiatives in the Great Barrier Reef Marine Park if these initiatives are consistent with their values, and if efforts are made to engage them in the decision making process. These results will enhance the ability of managers to generate support from the recreational fishing community for conservation initiatives in marine environments.
Brazil's evolving proposal to control deforestation: Amazon still at risk
Authors: FEARNSIDE PHILIP M. 
Published: December 2009

SUMMARYBrazil's National Plan for Climate Change (PNMC [Plano Nacional sobre Mudança do Clima]) brought the good news of quantified ‘objectives’ for deforestation reduction in Brazilian Amazonia, a departure from past policy, under which the Brazilian government has steadfastly refused any quantitative goals deforestation reduction in the context of reducing greenhouse gas emissions. However, the ‘objectives’ given in the PNMC carry no consequences if they are not met, other than possible suspension of contributions to the new Amazon Fund. The PNMC offers little information on how deforestation would be reduced, which is critical to achieving the results it proposes. Effective control of deforestation is needed both to avoid direct loss of the forest and to leverage the international commitment needed to contain global warming within a reasonable limit, such as 2°C. This is approximately the limit for avoiding replacement of substantial areas of Amazonian forest by either savannah or degraded secondary scrub. Brazil needs to move quickly to take the lead in the effort to halt global warming because it is one of the countries with the most to lose from climate change, including risk to the country's Amazon forest.
‘Feral’ and ‘wild’-type methicillin-resistantStaphylococcus aureusin the United Kingdom
Authors: MILLER R. , WALKER A. S. , KNOX K. , WYLLIE D. , PAUL J. , HAWORTH E. , MANT D. , PETO T. , CROOK D. W. 
Published: December 2009

SUMMARYCirculation of methicillin-resistantStaphylococcus aureus(MRSA) outside hospitals could alter the impact of hospital-based control strategies. We investigated two groups of cases (each matched to controls with MRSA): 61 ‘community cases’ not in acute hospital in the year before MRSA isolation; and 21 cases with ciprofloxacin-sensitive (CipS) MRSA. Multi-locus sequence typing,spa-typing and Panton–Valentine leukocidin gene testing were performed and demographics obtained. Additional questionnaires were completed by community case GPs. Community cases comprised 6% of Oxfordshire MRSA. Three community cases had received no regular healthcare or antibiotics: one was infected with CipS. Ninety-one percent of community cases had healthcare-associated sequence type (ST)22/36; CipS MRSA cases had heterogeneous STs but many had recent healthcare exposure. A substantial minority of UK MRSA transmission may occur outside hospitals. Hospital strains are becoming ‘feral’ or persisting in long-term carriers in the community with regular healthcare contacts; those with recent healthcare exposure may nevertheless acquire non-hospital epidemic MRSA strains in the community.
Common acute childhood infections and appendicitis: a historical study of statistical association in 27 English public boarding schools, 1930–1934
Authors: SMALLMAN-RAYNOR M. R. , CLIFF A. D. , ORD J. K. 
Published: December 2009

SUMMARYAlthough the involvement of common childhood infections in the aetiology of acute appendicitis has long been conjectured, supporting evidence is largely restricted to a disparate set of clinical case reports. A systematic population-based analysis of the implied comorbid associations is lacking in the literature. Drawing on a classic epidemiological dataset, assembled by the School Epidemics Committee of the United Kingdom's Medical Research Council (MRC) in the 1930s, this paper presents a historical analysis of the association between termly outbreaks of each of six common childhood infections (chickenpox, measles, mumps, rubella, scarlet fever and whooping cough) and operated cases of acute appendicitis in 27 English public boarding schools. When controlled for the potential confounding effects of school, year and season, multivariate negative binomial regression revealed a positive association between the level of appendicitis activity and the recorded rate of mumps (β=0·15, 95% CI 0·07–0·24,P<0·001). Non-significant associations were identified between appendicitis and the other sample infectious diseases. Subject to data caveats, our findings suggest that further studies are required to determine whether the comorbid association between mumps and appendicitis is causal.
Clinical and Economic Impact of Methicillin-Resistant Staphylococcus aureus Colonization or Infection on Neonates in Intensive Care Units
Authors: Song Xiaoyan , Perencevich Eli , Campos Joseph , Short Billie L. , Singh Nalini 
Published: December 2009

Objective.The rising incidence and mortality of methicillin-resistant Staphylococcus aureus (MRSA) colonization or infection in children has become a great concern. This study aimed to determine the clinical and economic impact of MRSA colonization or infection on infants and to measure excess mortality, length of stay, and hospital charges attributable to MRSA.Design.This is a retrospective cohort study.Setting and Patients.The study included infants admitted to a level III-IV neonatal intensive care unit from September 1, 2004, through March 31, 2008.Methods.A time-dependent proportional hazard model was used to analyze the association between MRSA colonization or infection and mortality. The relationships between MRSA colonization or infection and length of stay and between MRSA colonization or infection and hospital charges were assessed using a matched cohort study design.Results.Of 2,280 infants, 191 (8.4%) had MRSA colonization or infection. Of 132 MRSA isolates with antibiotic susceptibility results, 106 were resistant to clindamycin and/or trimethoprim-sulfamethoxazole, thus representing a noncommunity phenotype. The mortality rate was 17.8% for patients with MRSA colonization or infection and 11.5% for control subjects. Neither MRSA colonization (hazard ratio [HR], 0.9 [95% confidence interval {CI}, 0.5-1.5]; P > .05) nor infection (HR, 1.2 [95% CI, 0.7-1.9]; P > .05) was associated with increased mortality risk. Infection caused by MRSA strains that were resistant to clindamycin and/or trimethoprim-sulfamethoxazole increased the mortality risk by 40% (HR, 1.4 [95% CI, 0.9-2.2]; P > .05), compared with the mortality risk of control subjects, but the increase was not statistically significant. MRSA infection independently increased length of stay by 40 days (95% CI, 34.2—45.6; P < .001) and was associated with an extra charge of $164,301 (95% CI, $158,712-$169,889; P < .001).Conclusions.MRSA colonization or infection in infants is associated with significant morbidity and financial burden but is not independently associated with increased mortality.
Individual growth pattern and variability in Serranus scriba: a Bayesian analysis
Authors: Alós Josep , Palmer Miquel , Balle Salvador , Grau Antoni Maria , Morales-Nin Beatriz 
Published: December 2009

Abstract
Alós, J., Palmer, M., Balle, S., Grau, A. M., and Morales-Nin, B. 2010. Individual growth pattern and variability in Serranus scriba: a Bayesian analysis. – ICES Journal of Marine Science, 67: 502–512. Variability in growth patterns at an individual level in Serranus scriba is described using a Bayesian approach for a generalized von Bertalanffy growth model that accommodates one change in growth rate at a specific point during the lifespan. The approach enables individual growth curves to be inferred, even in a species with a relatively short lifespan and no commercial value, i.e. limited sample sizes available, but potentially endangered by recreational fishing. The change in growth rate may be the result of differing allocation of energy between reproductive and somatic activities at different ages. Overall, the approach presented provides adequate input for future implementation of population dynamics models that take into account individual variability, e.g. individual-based models, even for species for which limited data are available.
Bifurcation to fronts due to delay
Authors: Erneux T. , Kozyreff G. , Tlidi M. 
Published: December 2009

The stability of a steady-state front (kink) subject to a time-delayed feedback control (TDFC) is examined in detail. TDFC is based on the use of the difference between system variables at the current moment of time and their values at some time in the past. We first show that there exists a bifurcation to a moving front. We then investigate the limit of large delays but weak feedback and obtain a global bifurcation diagram for the propagation speed. Finally, we examine the case of a two-dimensional front with radial symmetry and determine the critical radius above which propagation is possible.
Quantifying stochasticity in the dynamics of delay-coupled semiconductor lasers via forbidden patterns
Authors: Tiana-Alsina Jordi , Buldú Javier M. , Torrent M. C. , García-Ojalvo Jordi 
Published: December 2009

We quantify the level of stochasticity in the dynamics of two mutually coupled semiconductor lasers. Specifically, we concentrate on a regime in which the lasers synchronize their dynamics with a non-zero lag time, and the leader and laggard roles alternate irregularly between the lasers. We analyse this switching dynamics in terms of the number of forbidden patterns of the alternate time series. The results reveal that the system operates in a stochastic regime, with the level of stochasticity decreasing as the lasers are pumped further away from their lasing threshold. This behaviour is similar to that exhibited by a single semiconductor laser subject to external optical feedback, as its dynamics shifts from the regime of low-frequency fluctuations to coherence collapse.
Efficacy of repetitive transcranial magnetic stimulation in alcohol dependence: a sham‐controlled study
Authors: Mishra Biswa R. , Nizamie S. Haque , Das Basudeb , Praharaj Samir K. 
Published: December 2009

ABSTRACTObjective  To study the anticraving efficacy of high‐frequency repetitive transcranial magnetic stimulation (rTMS) of the right dorsolateral pre‐frontal cortex (DLPFC) in patients with alcohol dependence.Methods  We performed a prospective, single‐blind, sham‐controlled study involving 45 patients with alcohol dependence syndrome (according to ICD‐10 DCR), with Clinical Institute of Withdrawal Assessment in Alcohol Withdrawal (CIWA‐Ar) scores ≤10. Patients were allocated to active and sham rTMS in a 2 : 1 ratio, such that 30 patients received active and 15 patients sham rTMS to the right DLPFC (10 Hz frequency, 4.9 seconds per train, inter‐train interval of 30 seconds, 20 trains per session, total 10 sessions). The Alcohol Craving Questionnaire (ACQ‐NOW) was administered to measure the severity of alcohol craving at baseline, after the last rTMS session and after 1 month of the last rTMS session.Results  Two‐way repeated‐measures analysis of variance (ANOVA) showed significant reduction in the post‐rTMS ACQ‐NOW total score and factor scores in the group allocated active rTMS compared to the sham stimulation. The effect size for treatment with time interaction was moderate (η2 = 0.401).Conclusions  Right dorsolateral pre‐frontal high‐frequency rTMS was found to have significant anticraving effects in alcohol dependence. The results highlight the potential of rTMS which, combined with other anticraving drugs, can act as an effective strategy in reducing craving and subsequent relapse in alcohol dependence.
Cognitive enhancement as a pharmacotherapy target for stimulant addiction
Authors: Sofuoglu Mehmet 
Published: December 2009

ABSTRACTBackground No medications have been proven to be effective for cocaine and methamphetamine addiction. Attenuation of drug reward has been the main strategy for medications development, but this approach has not led to effective treatments. Thus, there is a need to identify novel treatment targets in addition to the brain reward system.Aim To propose a novel treatment strategy for stimulant addiction that will focus on medications enhancing cognitive function and attenuating drug reward.Methods Pre‐clinical and clinical literature on potential use of cognitive enhancers for stimulant addiction pharmacotherapy was reviewed.Results and conclusions Cocaine and methamphetamine users show significant cognitive impairments, especially in attention, working memory and response inhibition functions. The cognitive impairments seem to be predictive of poor treatment retention and outcome. Medications targeting acetylcholine and norepinephrine are particularly well suited for enhancing cognitive function in stimulant users. Many cholinergic and noradrenergic medications are on the market and have a good safety profile and low abuse potential. These include galantamine, donepezil and rivastigmine (cholinesterase inhibitors), varenicline (partial nicotine agonist), guanfacine (alpha2‐adrenergic agonist) and atomoxetine (norepinephrine transporter inhibitor). Future clinical studies designed optimally to measure cognitive function as well as drug use behavior would be needed to test the efficacy of these cognitive enhancers for stimulant addiction.
Infra‐red thermometry of alpine landscapes challenges climatic warming projections
Authors: SCHERRER DANIEL , KÖRNER CHRISTIAN 
Published: December 2009

AbstractRough mountain terrain offers climatic conditions (niches) to plants and animals poorly represented by conventional climate station data. However, the extent to which actual temperatures deviate from those of the freely circulating atmosphere had never been assessed at a landscape level. Here, we quantify thermal life conditions across topographically rich mountain terrain by using a combination of thermal (IR) imagery of surface temperature with data from a large number of miniature data loggers buried at 3 cm soil depth. The data obtained from six alpine (Alps) and arctic‐alpine slopes (Norway, Sweden, Svalbard) evidence persistent root zone temperatures of 2–4 K above air temperature during summer. Surface temperatures show strong positive (2–9 K) and negative (3–8 K) deviations from air temperature on bright days and clear nights, respectively. As to be expected, south oriented slopes are warmer than west and north slopes but microclimatic variation on clear sky days was strong within all slopes, with 8.4±2.5 K (mean±SD) surface temperature differences persisting over several hours per day along horizontal (i.e., equal elevation) transects. Life conditions of alpine organisms are thus strongly decoupled from conditions in the free atmosphere and cannot reliably be inferred from climate station data in both, temperate and arctic latitudes. Microtopography can mimic temperature differences of large elevational (or latitudinal) gradients over very short horizontal distances. This is important in the context of climate change because it shows that species do not necessarily need to climb several hundred meters in elevation to escape the warmth. Quite often, few meters of horizontal shift will do. For plants unable to, or too slow to adapt to a warmer climate, thermal microhabitat mosaics offer both refuge habitats as well as stepping stones as atmospheric temperatures rise.
Weak associations between human leucocyte antigen genotype and acute myocardial infarction
Authors: Björkbacka H. , Lavant E. H. , Fredrikson G. N. , Melander O. , Berglund G. , Carlson J. A. , Nilsson J. 
Published: December 2009

Abstract.  Björkbacka H, Lavant EH, Fredrikson GN, Melander O, Berglund G, Carlson JA, Nilsson J (Lund University, Malmö University Hospital, Malmö; and Lund University, Lund University Hospital, Lund; Sweden). Weak associations between human leucocyte antigen genotype and acute myocardial infarction. J Intern Med 2010; 268:50–58.Objectives.  Human leucocyte antigens (HLAs) are polymorphic molecules involved in antigen presentation. Associations between HLA type and autoimmune diseases, such as type 1 diabetes and rheumatoid arthritis, are well established but the potential association of genetic variation affecting antigen presentation with cardiovascular disease has not been systematically investigated in large cohorts. The importance of such studies is stressed by recent experimental findings of an involvement of autoimmunity in the atherosclerotic disease process.Results.  An SSP‐PCR method was used for HLA genotyping to determine associations of HLA‐DRB1, ‐DQA1 and ‐DQB1 with cardiovascular disease in a population‐based cohort of 1188 acute myocardial infarction (AMI) patients and 1191 matched healthy controls. The HLA‐DRB1*0101 allele, as well as the HLA‐DRB1*0101‐DQA1*01‐DQB1*05 haplotype, was found to be associated with increased risk for AMI (OR 1.24; 95% CI 1.00–1.54 for both). In contrast, the DRB1*07 and DQA*02 alleles (OR 0.78; 95% CI 0.65–0.95 for both), as well as the DRB1*07‐DQA*02‐DQB*02 haplotype, conferred protection (OR 0.79; 95% CI 0.63–0.98). An HLA risk score taking each individual’s both haplotypes into account was higher amongst cases (2.43 ± 0.92 vs. 2.29 ± 0.95, P = 0.001). The association between HLA risk score and AMI was independent of other cardiovascular risk factors assessed.Conclusions.  This study demonstrates that the associations between HLA‐DRB1 and DQA1 loci and cardiovascular disease exists but that they are considerably weaker than those previously reported for other diseases with an established autoimmune aetiology such as type 1 diabetes, systemic lupus erythematosus and rheumatoid arthritis.
Cutaneous infiltrates and peripheral blood immune responses in dogs with immunomodulatory‐responsive lymphocytic–plasmacytic pododermatitis
Authors: Breathnach Rory M. , Fanning Shay , Mulcahy Grace , Bassett Hugh F. , Strobl Eric , Jones Boyd R. 
Published: December 2009

AbstractThis study characterizes T‐ and B‐lymphocyte responses in the peripheral blood and lesional skin of dogs with immunomodulatory‐responsive lymphocytic–plasmacytic pododermatitis (ImR‐LPP), a term previously proposed to denote a subpopulation of dogs with idiopathic pododermatitis. T‐cell (CD3+, CD4+ and CD8+) and B‐cell (CD21+) counts were significantly increased in both the epidermis and dermis of lesional ImR‐LPP skin compared with that in pedal skin from healthy controls. CD3+, CD4+, CD8+ and CD21+ cells were commonly observed in perivascular sites in the superficial dermis, periadnexally, beneath the dermal–epidermal (DE) junction and in the epidermis of lesional ImR‐LPP skin. The CD8+/CD3+ T‐cell ratio in peripheral blood was significantly increased in the ImR‐LPP group (0.42 versus 0.35 in controls). Serum IgA, IgG and IgM concentrations were all significantly elevated in affected dogs. Lymphocyte stimulation indices in ImR‐LPP dogs were comparable with control levels except for a lower response to ionomycin (6.0 versus 11.1). Dogs with ImR‐LPP had a higher incidence and mean (semi‐quantitative) score for IgA, IgG and IgM deposits in the epidermis, and a significantly increased incidence of dermal IgA+, IgG+ and IgM+ mononuclear inflammatory cells. The results indicate that upregulated T‐ and B‐lymphocyte responses may contribute to the pathogenesis of the skin lesions observed in dogs with ImR‐LPP.
Preservation of the donor pancreas for whole pancreas and islet transplantation
Authors: Ridgway Dan , Manas Derek , Shaw James , White Steve 
Published: December 2009

Ridgway D, Manas D, Shaw J, White S. Preservation of the donor pancreas for whole pancreas and islet transplantation. Clin Transplant 2010: 24: 1–19. © 2009 John Wiley & Sons A/S.Abstract: Whole pancreas and islet cell transplantation are both reliant upon the procurement and preservation of a high quality donor pancreas for a successful outcome. In the climate of a reducing donor pool it is imperative that donor optimization, meticulous surgical retrieval and evidence based methods of preservation are practiced to ensure optimal graft quality. Moreover expanded criteria donors and novel methods of pancreas preservation have the potential to expand the number of usable grafts and increase the availability of these transplant modalities to suitable patients with diabetes. This article provides a review of the current literature surrounding donor management, surgical technique and the various technologies of organ preservation applicable to the donor pancreas.
Regional cerebral blood flow responses to hyperventilation during sevoflurane anaesthesia studied with PET
Authors: SCHLÜNZEN L. , VAFAEE M. S. , JUUL N. , COLD G. E. 
Published: December 2009

Background: Arterial carbon dioxide tension (PaCO2) is an important factor controlling cerebral blood flow (CBF) in neurosurgical patients. It is still unclear whether the hypocapnia‐induced decrease in CBF is a general effect on the brain or rather linked to specific brain regions. We evaluated the effects of hyperventilation on regional cerebral blood flow (rCBF) in healthy volunteers during sevoflurane anaesthesia measured with positron emission tomography (PET).Methods: Eight human volunteers were anaesthetized with sevoflurane 1 MAC, while exposed to hyperventilation. During 1 MAC sevoflurane at normocapnia and 1 MAC sevoflurane at hypocapnia, one H215O scan was performed. Statistical parametric maps and conventional regions of interest analysis were used for estimating rCBF differences.Results: Cardiovascular parameters were maintained constant over time. During hyperventilation, the mean PaCO2 was decreased from 5.5 ± 0.7 to 3.8 ± 0.9 kPa. Total CBF decreased during the hypocapnic state by 44%. PET revealed wide variations in CBF between regions. The greatest values of vascular responses during hypocapnia were observed in the thalamus, medial occipitotemporal gyrus, cerebellum, precuneus, putamen and insula regions. The lowest values were observed in the superior parietal lobe, middle and inferior frontal gyrus, middle and inferior temporal gyrus and precentral gyrus. No increases in rCBF were observed.Conclusions: This study reports highly localized and specific changes in rCBF during hyperventilation in sevoflurane anaesthesia, with the most pronounced decreases in the sub cortical grey matter. Such regional heterogeneity of the cerebral vascular response should be considered in the assessment of cerebral perfusion reserve during hypocapnia.