bluuebunny/crossref_metadata_2025_split huggingface dataset:
PPARδ activation inhibits angiotensin II induced cardiomyocyte hypertrophy by suppressing intracellular Ca2+ signaling pathway
Authors: Lee Kuy‐Sook , Park Jin‐Hee , Lee Seahyoung , Lim Hyun‐Joung , Park Hyun‐Young 
Published: March 2009

AbstractPeroxisome proliferator‐activated receptors δ (PPARδ) is known to be expressed ubiquitously, and the predominant PPAR subtype of cardiac cells. However, relatively less is known regarding the role of PPARδ in cardiac cells except that PPARδ ligand treatment protects cardiac hypertrophy by inhibiting NF‐κB activation. Thus, in the present study, we examined the effect of selective PPARδ ligand L‐165041 on angiotensin II (AngII) induced cardiac hypertrophy and its underlying mechanism using cardiomyocyte. According to our data, L‐165041 (10 µM) inhibited AngII‐induced [3H] leucine incorporation, induction of the fetal gene atrial natriuretic factor (ANF) and increase of cardiomyocyte size. Previous studies have implicated the activation of focal adhesion kinase (FAK) in the progress of cardiomyocyte hypertrophy. L‐165041 pretreatment significantly inhibited AngII‐induced intracellular Ca2+ increase and subsequent phosphorylation of FAK. Further experiment using Ca2+ ionophore A23187 confirmed that Ca2+ induced FAK phosphorylation, and this was also blocked by L‐165041 pretreatment. In addition, overexpression of PPARδ using adenovirus significantly inhibited AngII‐induced intracellular Ca2+ increase and FAK expression, while PPARδ siRNA treatment abolished the effect of L‐165041. These data indicate that PPARδ ligand L‐165041 inhibits AngII induced cardiac hypertrophy by suppressing intracellular Ca2+/FAK/ERK signaling pathway in a PPARδ dependent mechanism. J. Cell. Biochem. 106: 823–834, 2009. © 2009 Wiley‐Liss, Inc.
Personal coaching as a positive intervention
Authors: Biswas‐Diener Robert 
Published: March 2009

AbstractPersonal coaching is a relatively new and unlicensed profession aimed at helping functioning individuals set and achieve goals, overcome obstacles, and maintain motivation. Coaching is increasingly merging with psychology as evidenced by new journals, academic programs, and research symposia. Although coaching has traditionally been used with non‐clinical populations, it can be highly relevant to psychotherapy. Clinicians who develop a hybrid psychotherapy‐coaching practice might be better protected from occupational stress and burnout. In addition, a number of coaching interventions and assessments might translate well to therapy and help clinicians innovate their practice. The synergy between personal coaching and psychotherapy are illustrated with a case example. © 2009 Wiley Periodicals, Inc. J Clin Psychol: In Session 65: 1–10, 2009.
Well‐being therapy for generalized anxiety disorder
Authors: Ruini Chiara , Fava Giovanni A. 
Published: March 2009

AbstractWell‐being therapy (WBT) aims to enhance psychological well‐being based on Ryff's (1989) six dimensions: autonomy, personal growth, environmental mastery, purpose in life, positive relations, and self‐acceptance. Previous studies have documented the efficacy of this psychotherapy in treating patients with mood and anxiety disorders and in preventing relapse in recurrent depression. We discuss and illustrate the use of WBT in generalized anxiety disorder. We present a case of a patient suffering from generalized anxiety disorder treated with cognitive‐behavioral therapy followed by WBT. © 2009 Wiley Periodicals, Inc. J Clin Psychol: In Session 65: 1–10, 2009.
Batch treatment of liquid fraction of pig slurry by intermittent aeration: process simulation and microbial community analysis
Authors: Magrí Albert , Guivernau Miriam , Baquerizo Guillermo , Viñas Marc , Prenafeta‐Boldú Francesc X , Flotats Xavier 
Published: March 2009

AbstractBACKGROUND: Manure treatment in intensive livestock farming is required to reduce the risk of negative environmental impacts by nitrogen disposal. Biological removal through intermittent aeration in a single bioreactor is a suitable method for this purpose. The characteristic operation based on the alternation of oxic/anoxic phases confers these systems with certain particularities in terms of process modelling and of understanding the microbial interactions.RESULTS: The performance of a sequencing batch reactor (SBR) treating raw liquid fraction of pig slurry (LFPS) under loading rates of 0.13 g N L−1 d−1 was studied. Three different aeration strategies were applied: (1) constant airflow; (2) dissolved oxygen (DO) set‐point; and (3) DO‐based real‐time control. The comparatively low aeration intensity applied throughout the third strategy resulted in the process being performed mainly via nitrite, implying a reduction on the requirements of organic carbon and oxygen. However, a decrease in the nitrification rate was observed under those conditions. Experimental results were satisfactorily simulated by a mathematical model focused on organic carbon and nitrogen removal. Microbial community structure analysis through denaturing gradient gel electrophoretic profiling of 16S rDNA genes showed that the aeration exerted a strong influence on the dominant microbial populations. The presence of the ammonia‐oxidizing species Nitrosomonas europaea, and of denitrifying bacteria related to Thauera sp. and Ralstonia sp., was detected in the strategy at low DO.CONCLUSION: Dependence of model statement and parameter values on the bioreactor operational patterns and piggery wastewater composition was evidenced. Oxygen limitation was responsible for a significant microbial shift in SBR treating LFPS. Copyright © 2009 Society of Chemical Industry
Survival impact of nodal disease in hard palate and maxillary alveolus cancer
Authors: Lin Harrison W. , Bhattacharyya Neil 
Published: March 2009

AbstractObjective:Evaluate the impact of primary site stage and cervical metastasis on the survival of patients with squamous cell carcinoma (SCC) of the hard palate or maxillary alveolus.Study Design:Cross‐sectional population analysis of prospectively maintained database.Methods:Cases of hard palate and maxillary alveolus SCC from 1988–2004 were extracted from the Surveillance, Epidemiology, and End Results database. Demographic data and extent of disease were extracted for each case, and T‐stage, and N‐stage were computed. Survival differences according to T‐stage and N‐stage were determined with the Kaplan‐Meier method and the log‐rank test.Results:Four hundred eleven cases of maxillary alveolus and 314 cases of hard palate SCC were identified, for a total of 725 cases (53.9% female, mean age: 70.9 years). The prevalence of cervical metastasis was not significantly different according to primary site (P = .181); advanced N‐stage significantly correlated with more advanced T‐stage (P < .001). Of the 725 cases, 4.1% of T1 tumors, 14.9% of T2 tumors, 10.3% of T3 tumors, and 24.7% of T4 tumors had cervical nodal metastases. The mean overall survivals were 96.5, 69.1, 67.8, and 49.3 months for T1–T4 tumors, respectively (P < .001). With regard to N‐stage, the mean survivals were 73.7, 69.7, 29.8, and 5.5 months for N0–N3 lesions, respectively (P < .001). Nodal metastasis effect on survival remained significant (P < .039) in stratified survival analysis except for T3 lesions (P = .205).Conclusions:Survival in patients with SCC of either the hard palate or maxillary alveolus is significantly influenced by T‐stage and a nonnegligible rate of cervical nodal metastases. Laryngoscope, 119:312–315, 2009
Peculiar Behavior of Degenerative Chain Transfer Polymerization of a Phosphonated Methacrylate
Authors: David Ghislain , Asri Zhor El , Rich Samantha , Castignolles Patrice , Guillaneuf Yohann , Lacroix‐Desmazes Patrick , Boutevin Bernard 
Published: March 2009

AbstractLiving/controlled radical polymerization of dimethyl(methacryloyloxy)methyl phosphonate (MAPC1) has been attempted using degenerative transfer to produce block copolymers. RAFT polymerization of this monomer is sensitive to very low level of oxygen and in any case limited to low monomer conversion. Reverse iodine transfer polymerization (RITP) leads to higher monomer conversion with a limited amount of living polymer (55% by 1H NMR), precluding an efficient synthesis of block copolymers. A PMMA‐b‐PMAPC1 diblock copolymer was therefore synthesized by iodine transfer polymerization (ITP) of MAPC1 from a PMMA‐I macro‐chain transfer agent prepared by RITP. The diblock copolymer, purified by selective precipitation, contains an average of five MAPC1 units and has potential an adhesive and as a corrosion inhibitor.magnified image
AB2 Functional Polyesters via Ring Opening Polymerization: Synthesis and Characterization
Authors: Velthoen Ingrid W. , Dijkstra Pieter J. , Feijen Jan 
Published: March 2009

AbstractAliphatic AB2 functional polyesters were conveniently prepared by the ring opening polymerization of ε‐caprolactone and L‐lactide in the presence of the AB2 functional initiator 2,2‐bis(hydroxymethyl)propionic acid (bis‐MPA) and Sn(Oct)2 as the catalyst. In L‐lactide polymerization, both bis‐MPA hydroxyl groups initiated the polymerization reaction, but for ε‐caprolactone polymerization this depended on the monomer to initiator to catalyst ratio. Initiation at two hydroxyl groups occurred at high monomer to initiator ([M]/[I]) ratio and at high Sn(Oct)2 to monomer ratio. The melting temperatures of the AB2‐functional PLLA and PCL polymers were comparable to linear polymers with a $\overline {DP}$ equal to the $\overline {DP}$ per arm in the polymer.magnified image
Attitudes of Chinese couples in Hong Kong regarding using preimplantation genetic diagnosis (PGD) and human leukocyte antigens (HLA) typing to conceive a ‘Saviour Child’
Authors: Hui Edwin C. , Chan Carina , Liu Athena , Chow Kathy 
Published: March 2009

AbstractObjectivesTo investigate Hong Kong couples' attitudes and concerns about using preimplantation genetic diagnosis (PGD) and human leukocyte antigens (HLA) typing to conceive a disease‐free and tissue‐compatible ‘Saviour Child (SC)’ to save an afflicted sibling.MethodsTwo cohorts of Chinese couples, one with natural pregnancies and the other receiving in vitro fertilization (IVF) services, were studied using a structured questionnaire.ResultsAlthough most couples believed that embryos possess moral rights, they considered it acceptable to reproduce a donor child if it was safe for the child, and tissue transplantation was the only available treatment for the sick sibling. Most couples believed that the donor child would not suffer adverse physical or psychological effects but rather would gain positive psychological benefits, and opined that parents using PGD/HLA‐typing suffer sacrificially for their children. In response to one specific question, one‐third of the couples agreed to use the donor child as a lifetime organ donor and supported the use of PGD for non‐medical gender selection. One‐quarter were willing to reject PGD/HLA‐typing because of its potential for non‐medical genetic enhancement.ConclusionProbably influenced by the Chinese tradition of strong familism, couples in Hong Kong generally show positive attitudes towards using PGD/HLA‐typing to reproduce a ‘SC’ to save a sibling affected with life‐threatening diseases amenable to treatment with genetically compatible tissue. Copyright © 2009 John Wiley & Sons, Ltd.
Antibiotic Prophylaxis before second‐trimester Genetic Amniocentesis (APGA): a single‐centre open randomised controlled trial
Authors: Giorlandino Claudio , Cignini Pietro , Cini Marco , Brizzi Cristiana , Carcioppolo Ornella , Milite Vincenzo , Coco Claudio , Gentili Paolo , Mangiafico Lucia , Mesoraca Alvaro , Bizzoco Domenico , Gabrielli Ivan , Mobili Luisa 
Published: March 2009

AbstractObjectiveTo compare procedure‐related pregnancy loss after second‐trimester genetic amniocentesis in women given an antibiotic prophylaxis and controls.MethodsProspective, open randomised controlled single‐centre study between January 1999 and December 2005 at Artemisia Fetal Maternal Medical Centre. A follow‐up within 4 weeks after the procedure was done.Of 36 347 eligible women, 1424 refused to participate and 34 923 were enrolled and randomised with unequal chance of selection, 21 991 were assigned to treatment group and 12 932 were assigned to the control group, and did not receive any placebo. Oral azithromycin, 500 mg per day, was administered 3 days before amniocentesis. The primary endpoint was the procedure‐related pregnancy loss. The secondary endpoint was the rate of preterm premature rupture of membranes.ResultsThe rate of abortion related to the amniocentesis was 7/21 219 women (0.03%, 95% CI 0.009–0.057) in the intervention group, and 36/12 529 (0.28%, 0.28–0.30) in controls (p= 0.0019). The rate of preterm premature rupture of membranes was 14/21 219 (0.06%, 0.031–0.101) in the intervention group, and 140/12 529 (1.12%, 0.94–1.30) in the control group (p= 0.001).ConclusionsAntibiotic prophylaxis before second‐trimester amniocentesis reduced the risk of abortion and of rupture of the membranes. Copyright © 2009 John Wiley & Sons, Ltd.
Atorvastatin modifies the protein profile of circulating human monocytes after an acute coronary syndrome
Authors: Barderas María G. , Tuñón José , Dardé Verónica M. , De la Cuesta Fernando , Jiménez‐Nácher José J. , Tarín Nieves , López‐Bescós Lorenzo , Egido Jesús , Vivanco Fernando 
Published: March 2009

AbstractAggressive treatment with high‐dose atorvastatin reduces more effectively the incidence of cardiovascular events than moderate statin therapy. The mechanism of this benefit has not been fully elucidated. In order to know the potential effects of statin treatment on the protein expression of circulating monocytes in acute coronary syndrome (ACS) patients, a proteomic analysis of these cells was carried out by 2‐DE and MS. Twenty‐five patients with non‐ST‐elevation acute coronary syndrome (NSTEACS) were randomized, the fourth day after admission, to receive ATV 80 mg/dL (n = 14) or conventional treatment (CT) (n = 11), for two months. Blood was withdrawn at the end of the treatment, and monocytes were extracted for proteomic analysis and their protein expression patterns determined. Age, sex, total cholesterol, LDL, HDL, triglycerides, body mass index, presence of hypertension, diabetes, and smoking status were not significantly different between the two groups of patients. The expression of 20 proteins was modified by intensive ATV. Among the most relevant results stand out the normalization by intensive ATV treatment of the expression of proteins that modulate inflammation and thrombosis such as protein disulfide isomerase ER60 (PDI), Annexin I, and prohibitin, or that have other protective effects as HSP‐70. Thus, this approach shed light at the molecular level of the beneficial mechanisms of anti‐atherothrombotic drugs.
Serially coupled microcolumn reversed phase liquid chromatography for shotgun proteomic analysis
Authors: Tao Dingyin , Zhu Guijie , Sun Liangliang , Ma Junfeng , Liang Zhen , Zhang Weibing , Zhang Lihua , Zhang Yukui 
Published: March 2009

AbstractMicrocolumn RPLC (μRPLC) is one of the optimum separation modes for shotgun proteomic analysis. To identify as many proteins as possible by MS/MS, the improvement on separation efficiency and peak capacity of μRPLC is indispensable. Although the increase in column length is one of the effective solutions, the preparation of a long microcolumn is rather difficult due to the high backpressure generated during the packing procedure. In our recent work, through connecting microcolumns of 5, 10, and 15 cm length via unions with minimal dead volume, long microcolumns with length up to 30 cm were obtained, with which 318 proteins were identified from proteins extracted from Escherichia coli by μRPLC‐ESI MS/MS, and similar distributions of Mw and pI were found with single and various coupled microcolumns. Furthermore, by using MS/MS with improved sensitivity, with such a serially coupled 30 cm long microcolumn, 1692 proteins were identified within 7 h from rat brain tissue, with false positive rate (FPR) <1%. All these results demonstrated that serially couple microcolumns might be of great promising to improve the separation capacity of μRPLC in shotgun proteomic analysis.
PEO‐Like Coatings Prepared by Plasma‐Based Techniques
Authors: Choukourov Andrei , Polonskyi Oleksandr , Hanus Jan , Kousal Jaroslav , Grinevich Andrey , Slavinska Danka , Biederman Hynek 
Published: March 2009

AbstractPolyethylene oxide (PEO)‐like films were prepared by rf magnetron sputtering of PEO and by thermal evaporation of PEO with and without activation by argon plasma. Rf magnetron sputtering under low power (<10 W) leads to deposition of the films with significant loss of ether structure. Under higher power, a co‐evaporation regime is achieved and the resultant films are richer in ether groups. Thermal evaporation of PEO proves to be even more effective in retention of ether structure. The films evaporated without activation by plasma are very close in composition to original material, yet they are soluble in water. Activation of the flux of evaporated species by Ar plasma results in enhanced cross‐linking and better stability in water, however at expense of retention of PEO character.
Hybrid Inorganic–Organic Functional Coatings for Injection Molding Applications
Authors: Burmeister Frank , Hagen Jan , Denter Joern , Wirth Marco , Fromm Alexander , Kleer Guenter 
Published: March 2009

AbstractWe report on the development of a nanostructured, inorganic–organic hybrid tool coating for functionalizing surfaces of plastic components via replication processes. First, an inorganic TiAlN‐coating is deposited in a reactive RF‐magnetron process as a carrier of the functional nanostructure. In the second step, the organic top coating is deposited via plasma polymerization of fluor‐containing hydrocarbons on top of the hard coating. Investigations were carried out concerning the hybrid coating's morphology, its surface energies and its thermomechanical stability in replication processes. The hybrid coating has been deposited on tools and replicated into polymethylmethacrylate. A significant lowering of the demolding forces in comparison to solely inorganic coatings was observed.
Creation of Vias With Optimized Profile for 3‐D Through Silicon Interconnects (TSV)
Authors: Richter Karola , Viehweger Kay , He Jian , Bartha Johann‐Wolfgang 
Published: March 2009

AbstractThe continually growing functionality and pattern density of semiconductor devices leads to the development of innovative and cost‐effective 3‐D stacking and interconnection technologies for ICs and MEMS. These include the formation of vias for interconnects by deep reactive ion etch (DRIE) of silicon. The commonly used DRIE based on a Bosch patent creates holes with vertical sidewalls. However, holes with tapered sidewalls are advantageous, because their widened opening facilitates following deposition and filling processes and a bevelled upper edge of the vias prevents deposited layers from breaking. We created such holes by an optimized positive profile etching (PPE) process. Furthermore, we post‐treated holes with vertical sidewalls to eliminate the sharp edge at their opening and to widen this region. We created blind holes with tapered sidewalls with a diameter of 5–10 µm and through silicon holes with a diameter of 40 µm and aspect ratios up to 10.
Some Effects of Corona Plasma Treatment of Polylactide/Montmorillonite Nanocomposite Films
Authors: Żenkiewicz Marian , Richert Józef , Rytlewski Piotr , Moraczewski Krzysztof 
Published: March 2009

AbstractInfluence of the unit energy (Eu) of corona discharge used for modification of pure polylactide (PLA) and polylactide nanocomposite (PLAC) containing 5 wt% of an aluminosilicate nanofiller (Cloisite 30B) on water (ΘW) and diiodomethane (ΘD) contact angles as well as on surface free energy (γs) of these polymers was studied. ΘW and ΘD as advancing contact angles were measured with use of a goniometer while γs was calculated by the Owens–Wendt method. It was found that ΘW increased with the rising Eu while ΘD remained approximately constant. Assuming Eu = const, it could be stated that the increase in γs was much more evident for PLA than for PLAC. This increase resulted practically from the change in the polar component of γs because the dispersive component for the two materials only slightly decreased with increase in Eu.
Growth and structure of CuIn7Se11 single crystals and H2O/CuIn7Se11 photoelectrochemical cells
Authors: Bodnar I. V. , Gorbachov D. V. , Rud V. Yu. , Rud Yu. V. , Victorov A. 
Published: March 2009

AbstractSingle crystals of CuIn7Se11 ternary compound have been grown by directional crystallization of the melt at first time. The composition of the obtained single crystals was determined by electron probe X‐ray microanalysis, X‐ray method was used to determine their structure. It was established that the grown crystals are crystallized in hexagonal structure. H2O/CuIn7Se11 photoelectrochemical cells have been created on the given crystals at first time. The photosensitivity spectra from which the character of interband transitions and band gap values have been determined have been investigated. The created photoelectrochemical cells can be utilized as wide‐band photoconvertors of an optical radiation. (© 2009 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Optical and electrical characterization of FTO films grown by spray pyrolysis method
Authors: Oshima Minoru , Takemoto Yujin , Yoshino Kenji 
Published: March 2009

AbstractTransparent conducting thin films of fluorine‐doped SnO2 were deposited on glass substrates by spray pyrolysis technique in order to find out the effect of solution concentration. These films were prepared using various fluorine concentrations from 0 to 5 mol%. The films were all polycrystalline with tetragonal crystal structures. The best electro‐optic properties, an average transmittance of 82% and a resistivity of 1.4 × 10–3 Ωcm, a carrier concentration of 6.2 × 1020 cm–3, a mobility of 7.1 cm2/Vs, were achieved with fluorine doing concentration of 4 mol% at substrate temperature of 500 °C. (© 2009 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Synthesis and Crystal Structure of CaCo(H2O)[BP2O8(OH)]·H2O
Authors: Menezes Prashanth W. , Hoffmann Stefan , Prots Yurii , Kniep Rüdiger 
Published: March 2009

AbstractCaCo(H2O)[BP2O8(OH)]·H2O was synthesized under mild hydrothermal conditions and investigated by single crystal X–ray diffraction (triclinic, space group P (No. 2), a = 6.5793(3) Å, b = 7.8320(1) Å, c = 8.8172(1) Å, α = 68.785(7)°, β = 82.719(10)°, γ = 73.985(9)°, V = 406.930(19) Å3, Z = 2). The crystal structure contains layers stacked along [011]. The layers are built from isolated borophosphate oligomers, [B2P4O16(OH)2]8– (loop branched tetrahedral hexamers), which are interconnected by dimers of CoO3O2/2(H2O) coordination octahedra. Calcium ions and crystal water are located at the borders of the layers, close to intra‐layer cavities.