bluuebunny/crossref_metadata_2025_split huggingface dataset:
Safety and efficacy of desmopressin (DDAVP) in preventing hematoma expansion in intracranial hemorrhage associated with antiplatelet drugs use: A systematic review and metaanalysis
Authors: Shahzad Faizan , Ahmed Usman , Muhammad Ayesha , Shahzad Farhan , Naufil Syed Imam , Sukkari Mohamad Walid , Kamran Abdullah Bin , Murtaza Sara , Khalid Marwah Bintay , Shabbir Haroon , Saeed Sajeel 
Published: May 2024

AbstractIntroductionOne of the most serious complications associated with antiplatelet agents is antiplatelet‐associated intracranial hemorrhage (AA‐ICH). Desmopressin is a synthetic antidiuretic hormone (ADH) analog. It has been linked to improving patient outcomes in antiplatelet‐induced intracranial hemorrhage. The secondary outcomes included the incidence of thrombotic complications and neurological outcomes.MethodsA systematic search was conducted on three databases (PubMed, Cochrane, and ClinicalTrials.gov) to find eligible literature that compares desmopressin (DDAVP) versus controls in patients with AA‐ICH. The Mantel–Haenszel statistic was used to determine an overall effect estimate for each outcome by calculating the risk ratios and 95% confidence intervals (CI). Heterogeneity was measured using the I2 test. The risk of bias in studies was calculated using the New Castle Ottowa Scale.ResultsFive studies were included in the analysis with a total of 598 patients. DDAVP was associated with a nonsignificant decrease in the risk of hematoma expansion (RR = .8, 95% CI,.51–1.24; p = .31, I2 = 44%). It was also associated with a non‐significant decrease in the risk of thrombotic events (RR,.83; 95% CI,.25–2.76; p = .76, I2 = 30%). However, patients in the DDAVP group demonstrated a significant increase in the risk of poor neurological outcomes (RR, 1.31; 95% CI, 1.07–1.61; p = .01, I2 = 0%). The risk of bias assessment showed a moderate to low level of risk.ConclusionDDAVP was associated with a nonsignificant decrease in hematoma expansion and thrombotic events. However, it was also associated with a significantly poor neurological outcome in the patients. Thus, until more robust clinical trials are conducted, the use of DDAVP should be considered on a case‐to‐case basis.
The effect of competition from informal firms on proactive environmental strategies in emerging economies
Authors: Heredia Walter , Ponce Oliva Roberto D. , Vásquez‐Lavín Felipe 
Published: May 2024

AbstractDrawing on the Attention Base View (ABV) theory, this paper examines the adoption of Proactive Environmental Strategies (PES) by formal firms in emerging economies and explores the influence of informal competition. We investigate the moderating effects of contextual factors (number of formal competitors) and firm characteristics (CEO's experience). Using data from the 2019 World Bank Enterprise Survey, we apply a Negative Binomial model to a sample of 7,436 manufacturing firms across 25 emerging economies. Unlike previous evidence, our findings suggest that formal firms facing competition from informal counterparts tend to adopt PES to bolster competitiveness. However, the perception of high formal competition and the CEO's industry experience may reduce PES adoption. This study advances our understanding of PES adoption in emerging economies, emphasizing the significance of informal competition. It also increases the evidence of the ABV approach to environmental strategy research, offering insights for managing environmental challenges in emerging markets.
Buffer effects on protein sieving losses in ultrafiltration and their relationship to biophysical properties
Authors: Mohammadzadehmarandi Aylin , Zydney Andrew L. 
Published: May 2024

AbstractThe design of effective ultrafiltration/diafiltration processes for protein formulation requires the use of membranes with very high protein retention. The objective of this study was to examine the effects of specific buffers on the retention of a model protein (bovine serum albumin) during ultrafiltration. Albumin retention at pH 4.8 was significantly reduced in phosphate buffer compared with that in acetate, citrate, and histidine. This behavior was consistent with a small change in the effective albumin hydrodynamic diameter as determined by dynamic light scattering. The underlying conformational changes leading to this change in diameter were explored using circular dichroism spectroscopy and differential scanning calorimetry. These results provide important insights into the factors controlling protein retention during ultrafiltration and diafiltration.
Antitussive, Expectorant and Antipyretic Effect of the Ethanolic Extract of the Leaves of Momordica charantia L.
Authors: Feitosa Ribeiro Tiago , Carvalho de Souza Nathália Andrezza , Cícero de Lima Araújo Tarcísio , Ferreira Macedo Cícero André , Souza Silva Fabrício , de Oliveira Siqueira Andressa , Modesto Nascimento Menezes Pedro , Gomes de Melo Camila , Rolim Neto Pedro José , Gonçalves de Oliveira Junior Raimundo , Douglas Melo Coutinho Henrique , Raposo António , Araújo Rolim Larissa 
Published: May 2024

AbstractThe traditional use of the M. charantia L. plant to treat coughs, fever and expectoration is widely practiced in different cultures, but its effectiveness and safety still require scientific investigation. This study sought to perform a chemical analysis and evaluate the antitussive, expectorant and antipyretic effects of the ethanolic extract of M. charantia leaves (EEMc) in rats and mice. The EEMc was subjected to chemical analysis by HPLC‐DAD, revealing the presence of the flavonoids astragalin and isoquercetin. Acute oral toxicity in mice did not result in deaths, although changes in liver weight and stool consistency were observed. EEMc demonstrated an antitussive effect at doses of 100 and 300 mg/kg in mice subjected to cough induction by citric acid nebulization. Furthermore, it showed expectorant activity at a dose of 300 mg/kg, assessed based on the elimination of the phenol red marker in bronchoalveolar lavage. In the evaluation of antipyretic activity in rats, fever induced by Saccharomyces cerevisiae was reduced at all doses tested during the first hour after treatment. This innovative study identified the presence of astragalin and isoquercetin in EEMc and indicated that the extract has antitussive, expectorant and antipyretic properties. Therefore, EEMc presents itself as a promising option in herbal medicine for the treatment of respiratory symptoms and fever.
Analyzing the Chemical Constituents and In Vitro Biological Effects of Extracts Artemisia absinthium L. Extracts Obtained Using Different Methodologies and Solvents
Authors: Yagi Sakina , Zengin Gokhan , Ibrahime Sinan Kouadio , Yavuz Paksoy Mehmet , Cziáky Zoltán , Jekő József , Dall'Acqua Stefano 
Published: May 2024

AbstractThe present study aimed to investigate the chemical constituents of different extracts from aerial parts of A. absinthium and to evaluate their antioxidant and enzyme inhibition activity. Extracts were prepared by maceration, infusion or Soxhlet techniques. Results showed that the highest total phenolic and flavonoids contents was recorded respectively from the hexane extract prepared by maceration and ethyl acetate extract obtained by Soxhlet method. The characteristic compounds of Artemisia species artemetin, casticin, sesartemin and yangambin in addition to coumarins were identified in all extracts. Aqueous extract obtained by infusion exerted the highest radical scavenging and ions reducing properties while that prepared by maceration displayed the highest chelating power. Methanol extracts obtained by the two methods of extraction exerted the highest anti‐Tyr activity while that obtained by maceration showed the best α‐glucosidase inhibition activity. These findings indicated that A. absinthium is a rich source of bioactive molecules with possible therapeutic applications.
A Review on the Phytochemistry and Pharmacology of the Genus Sterculia
Authors: Wang Lu , Yan Yuan‐Cong , Hao Yi‐Meng , Zhuo Xiao‐Xia , Duan Hong‐Ting , Zhang Qing , Wang Li‐Ning , Qiu Feng 
Published: May 2024

AbstractThe Sterculia genus is comprised of approximately 300 species, which have been widely used as traditional medicines to treat inflammation, snake bites, gastrointestinal diseases, skin diseases, microbial infections and many other diseases. To gain a comprehensive understanding of the therapeutic potential of Sterculia plants, an extensive literature search was conducted in CNKI, Bing, Wanfang Database, Springer Database, Elsevier Database, Google Scholar, Baidu Scholar, PubMed, and other similar websites from January 1971 to March 2024. The research indicated that Sterculia species predominantly contain flavonoids, terpenoids, phenylpropanoids, fatty acids, alkaloids and other chemical components. A wide range of pharmacologic activities such as anti‐inflammatory, antioxidant, antibacterial and other biological activities have been reported. Nevertheless, there isn′t much scholarly research on the therapeutic material basis of the genus Sterculia. This review reports the ethnobotany, phytochemicals, and biological activities of the plants in the Sterculia genus as herbal remedies.
Mutant p53 reactivators protect breast cancer cells from ferroptosis
Authors: Rathnayake Dewmi Sandaru , Dlamini Samkeliso , Elkalawozgy Kadry , Tillekeratne L. M. Viranga , Taylor William R. 
Published: May 2024

AbstractFerroptosis is a novel nonapoptotic form of cell death characterized by iron‐dependent reactive oxygen species‐mediated lipid peroxidation. In several different cell systems, the tumor suppressor p53 can enhance sensitivity to ferroptotic inducers. At least half of all human cancers show loss of function of p53. Furthermore, many of those tumors express mutant forms of p53 that has lost its wild‐type function. Several groups have designed small molecules that can reactivate the wild‐type function of these missense p53 mutants. We reasoned that p53 reactivators may also enhance sensitivity of certain cancer cells to ferroptosis stimuli. To test this idea we combined a number of different p53 reactivators with small molecule inducers of ferroptosis. In contrast, we observed that several p53 reactivators protected cells from cell death induced by ferroptotic inducers. Surprisingly, this protection still occurred in p53‐null cell lines. We observed that these reactivators were neither free radical scavengers nor ion chelators. One of these p53 reactivator molecules, NSC 59984, reduced expression of GPX4, which is unlikely to explain its ability to reduce sensitivity to ferroptosis. We suggest that these p53 reactivators function via an unknown, p53‐independent manner to suppress ferroptosis.
Assessing the impact of Plectranthus amboinicus (Lour) Spreng leaf extract on bread quality
Authors: de Mendonça Luciana G. , Holanda Marcos H. B. , Leão Marcos V. de. S. , Galvão Andrêssa Maria M. T. , Carneiro Samuel V. , Guimarães Diana J. S. , Zambelli Rafael A. 
Published: May 2024

AbstractBackground and ObjectivesThe potential of Plectranthus amboinicus aqueous extract (PAAE) to enhance the quality properties of wheat bread was investigated. PAAE was incorporated as an ingredient in bread formulations to improve shelf life.FindingsThe results indicate that the technological characteristics of bread formulations were enhanced with the inclusion of up to 75% PAAE. This enhancement led to increased specific volume and expansion properties. Scanning electron microscopy analysis demonstrated improved interaction between gluten and starch. PAAE exhibited potential in retarding bread hardening and preventing mold growth.ConclusionsPAAE holds promise as a novel ingredient for use in baked products. Its inclusion in bread formulations significantly improved technological characteristics, including specific volume and color, and positively influenced the interaction between gluten and starch. Additionally, PAAE showed potential in extending the shelf life of bread and inhibiting fungal growth.Significance and NoveltyThis study is significant due to the introduction of a novel ingredient, PAAE, in the field of baking. The incorporation of this extract represents an innovation in the quest for improvements in the nutritional and technological properties of baked goods. The ability of PAAE to function as an antifungal agent holds great relevance for the food industry.
A case report of massive retrosternal goiter in a 54‐year‐old woman with symptoms of head and neck swelling and dyspnea
Authors: Sorouri Shahabaddin , Akbarianrad Samira , Naseri Maryam 
Published: May 2024

Key Clinical MessageAnterior mediastinal mass often is serious and its diagnosis requires a comprehensive evaluation involving imaging studies, pathological analysis and consultation with a multidisciplinary team involving radiologist, thoracic surgeons, and oncologist.
Partial Photoelectrocatalytic Oxidation of 3‐Methylpiridine in Green Conditions by Nanotube/Nanowire Ti/TiO2 Plates Prepared in Aqueous, Glycerol, or Ethylene Glycol Medium
Authors: Çetinkaya Sıdıka , Özcan Levent , Palmisano Leonardo , Yurdakal Sedat 
Published: May 2024

AbstractNanotube/nanowire structured TiO2 samples on Ti plates were prepared by anodic oxidation in aqueous, glycerol or ethylene glycol medium under different experimental conditions and characterized by XRD, SEM‐EDX, electrochemical methods (photocurrent profiles and electrochemical impedance spectroscopy). The nanostructured TiO2 was built on relatively large Ti plates, and consequently, in some preparation conditions, different morphologic properties were observed in the underside and upside zones of the electrodes, especially in ethylene glycol medium. The electrodes were tested for selective photoelectrocatalytic oxidation of 3‐methylpyridine to 3‐pyridinemethanol, 3‐pyridinemethanal and vitamin B3 in water under UVA irradiation. The best performance was found with the electrode prepared in ethylene glycol/water/NH4F (98/2/0.3 w/w) medium at 36 V potential for 3 h, while the worst was that prepared in aqueous medium which showed the shortest nanostructure length. Unlike photoelectrocatalysis and photocatalysis, no aromatic alcohol/carbonyl products were obtained in electrocatalytic and photolytic experiments. The selectivity values of the products were similar for the various electrodes, while the morphology of the nanotubes/nanowires and their quantity which affects the total active surface area were essential for the substrate conversion. The results also show that the photocurrent intensity, XRD peak intensity, and electrical conductivity are correlated with photoelectrocatalytic activity of the Ti/TiO2 electrodes.
The joint operation of five career indecision factors: A longitudinal examination
Authors: Xu Hui 
Published: May 2024

AbstractWhile extensive research has explored the taxonomy of career indecision, a longitudinal examination of the joint operation of major indecision factors is lacking. Tracking a sample of US college students (n = 261) over three time points, the current study examined a mediation model involving lack of readiness, neuroticism/negative affectivity, interpersonal conflicts, need for information, and choice/commitment anxiety. The results showed that need for information mediated the positive predictions of lack of readiness and interpersonal conflicts for subsequent choice/commitment anxiety. However, neuroticism/negative affectivity did not predict need for information while controlling for lack of readiness and interpersonal conflicts. Therefore, the current study suggests that motivational and interpersonal barriers could undermine readiness for committing to a career direction because these barriers could impede information collection. The theoretical and practical implications of this study are deliberated along with its limitations and recommendations for future studies.
Catalytic Epoxidation of Carbonyl Compounds via Carbonyl Ylides: from Racemic to Enantioselective
Authors: Qi Lin‐Jun , Zhou Bo , Ye Long‐Wu 
Published: May 2024

AbstractTransition metal‐catalyzed epoxidation of carbonyl compounds through carbonyl ylides represents a highly effective method for synthesizing a diverse range of valuable epoxides. This review offers an in‐depth overview of the latest developments in inter‐ and intramolecular epoxidation reactions involving metal carbenes and carbonyl compounds, encompassing both racemic to enantioselective transformations. These catalytic epoxidations are reviewed by highlighting their product selectivity, diversity and applicability, and the related mechanistic rationale is showcased where possible.
Self‐Assembled Bis‐Acridinium Tweezer Equilibria Controlled by Multi‐Responsive Properties
Authors: Hu Johnny , Launay Jean‐Pierre , Chaumont Alain , Heitz Valérie , Jacquot de Rouville Henri‐Pierre 
Published: May 2024

AbstractProtonated and methylated bis‐acridinium tweezers built around a 2,6‐diphenylpyridyl and an electron enriched 2,6‐di(p‐anisyl)pyridyl spacer have been synthesized. These tweezers can self‐assemble in their corresponding homodimers and the associated thermodynamic parameters have been probed in organic solvents. The switching properties of the tweezers have been exploited in biphasic transfer experiments showing the shift of the equilibria towards the homodimers. Moreover, the thermodynamic parameters of the formation of the reduced methylated homodimers investigated by electrochemical experiments revealed the dissociation of the dimers. Thus, in addition to solvent and temperature, the pH and redox responsiveness of the acridinium units of the tweezers make it possible to modulate to a larger extent the monomer‐dimer equilibria.
Three Perovskite Phases with Different Cation Orders in Sm2MnMn(Mn4−xSbx)O12
Authors: Liang Xuan , Yamaura Kazunari , Belik Alexei A. 
Published: May 2024

AbstractCation order, which can be controlled by synthesis conditions and stoichiometry, plays an important role in properties of perovskite materials. Here we show that aliovalent doping by Sb5+ in Sm2MnMn(Mn4−xSbx)O12 quadruple perovskite solid solutions can control cation orders in both A and B sites. Samples with 0.4≤x≤2 were synthesized by a high‐pressure, high‐temperature method at 6 GPa and 1770 K. Three regions with different cation orders were found at 0.5≤x≤1.0, x=1.5–1.6, and x=1.8. The 0.5≤x≤1.0 compositions have a B‐site‐disordered and A‐site columnar‐ordered structure with space group P42/nmc; the x=1.5 and 1.6 samples have a B‐site rock‐salt‐ordered and A‐site columnar‐ordered structure with space group P42/n; the x=1.8 sample has a B‐site rock‐salt‐ordered and A‐site‐disordered structure with space group P21/n. All the samples show one ferrimagnetic transition: TC increases from 35 K to 73 K for 0.5≤x≤1.0, TC=81 K for x=1.5 and 1.6, and TC=53 K for x=1.8.
Where Does Fouling Occur in Individual Random Packing Elements? A Simulative Investigation
Authors: Xia Marc , Inderwies Korbinian , Klein Harald , Rehfeldt Sebastian 
Published: May 2024

AbstractFouling in columns is a persistent challenge in the chemical process industry, leading to decreased efficiency and increased operating costs. This paper presents an investigation into fouling behavior on individual random packing elements in packed columns using computational fluid dynamics (CFD) simulations. The study aims to gain a deeper understanding of how fouling grows and impacts the flow behavior, predicting areas susceptible to fouling and providing insights for improved design. The simulation results are validated against experimental results and show good agreement.
Divergent Protein Engineering of Transaminase for the Synthesis of Chiral Rivastigmine and Apremilast Precursors†
Authors: Tang Langyu , Yang Xinjie , Sun Ningning , Wu Guojiao , Wu Yuzhou , Zhong Fangrui 
Published: May 2024

Comprehensive SummaryThe implementation of divergent protein engineering on the natural transaminase Vf‐ω‐TA led to the development of two effective mutants (M2 and M8), enabling the enzymatic synthesis of chiral amine precursors of Rivastigmine and Apremilast, respectively. The evolution of the enzymes was guided by crystal structures and a focused mutagenesis strategy, allowing them to effectively address the challenging ketone substrates with significant steric hindrance. Under the optimized reaction parameters, transamination proceeded smoothly in good conversions and with perfect stereochemical control (> 99% ee). These processes utilize inexpensive α‐methylbenzylamine as an amine donor and avoid the continuous acetone removal and costly LDH/GDH/NADH systems.
Subsurface flow model for estimating 2D wetting pattern in drip irrigation
Authors: Reddy Kowkuntla Rama Krishna , Singh Vivekanand 
Published: May 2024

AbstractNumerical model using 2D Richard’s equation in cylindrical polar coordinate system was developed to assess the soil wetting patterns in a drip irrigation system. A fully implicit finite‐difference scheme was used to solve equations with suitable initial and boundary conditions. The developed model was validated with an experimental result available in the literature, which shows a high level of concordance with low values of RMSE and R2 greater than 0.93 for all discharge rates. Furthermore, the versatility and applicability of the model were demonstrated for complex subsurface conditions considering homogeneous and heterogeneous soil profiles. Water ponding on the surface was observed in clay loam soil, contrasting with deep percolation in sandy loam soil. This underscores the significance of adjusting both discharge rate and irrigation frequency in accordance with prevailing soil conditions.
The mechanics of cilia and flagella: What we know and what we need to know
Authors: Lindemann Charles B. , Lesich Kathleen A. 
Published: May 2024

AbstractIn this review, we provide a condensed overview of what is currently known about the mechanical functioning of the flagellar/ciliary axoneme. We also present a list of 10 specific areas where our current knowledge is incomplete and explain the benefits of further experimental investigation. Many of the physical parameters of the axoneme and its component parts have not been determined. This limits our ability to understand how the axoneme structure contributes to its functioning in several regards. It restricts our ability to understand how the mechanics of the structure contribute to the regulation of motor function. It also confines our ability to understand the three‐dimensional workings of the axoneme and how various beating modes are accomplished. Lastly, it prevents accurate computational modeling of the axoneme in three‐dimensions.
The Importance of Spin‐Polarized Charge Reorganization in the Catalytic Activity of D‐Glucose Oxidase
Authors: Preeyanka Naupada , Zhu Qirong , Das Tapan Kumar , Naaman Ron 
Published: May 2024

AbstractThe front cover artwork is provided by Prof. Ron Naaman's group at the Weizmann Institute of Science. The image shows that direct electron transfer through GOx is governed by electron spins, which result from the chiral‐induced spin selectivity (CISS) effect. Read the full text of the Research Article at 10.1002/cphc.202400033.