bluuebunny/crossref_metadata_2025_split huggingface dataset:
Two‐Year Clinical Registry Follow‐up of Endothelial Progenitor Cell Capture Stent Versus Sirolimus‐Eluting Bioabsorbable Polymer‐Coated Stent Versus Bare Metal Stents in Patients Undergoing Primary Percutaneous Coronary Intervention for ST Elevation Myocardial Infarction
Authors: CHONG ERIC , POH KIAN KEONG , LIANG SHEN , LEE RONALD CHI‐HANG , LOW ADRIAN , TEO SWEE‐GUAN , TAN HUAY CHEEM 
Published: March 2010

Background: Endothelial progenitor cell (EPC) capture stent is designed to promote rapid endothelization and healing and is potentially useful in patients undergoing primary percutaneous coronary intervention (PCI) for acute myocardial infarction (AMI). We studied the intermediate‐term efficacy and safety of EPC stent and compared that with sirolimus‐eluting bioabsorbable polymer stent (CURA) and bare metal stent (BMS) in AMI patients.
Methodology: Patients presenting with AMI who underwent primary PCI with the respective stents between January 2004 and June 2006 were enrolled in the single‐center clinical registry. The study end‐points were major adverse cardiac events (MACE) and stent thrombosis.
Results: A total of 366 patients (EPC = 95, CURA = 53, BMS 218) were enrolled. Baseline demographics including age, gender, diabetes, renal impairment, predischarge left ventricular ejection fraction, and creatinine kinase level were comparable among the groups. Procedural success rate was 99.5%. Post‐procedural thrombolysis in myocardial infarction (TIMI) 3 flow was achieved in EPC 91.6%, CURA 96.2%, and BMS 88.5% (P = 0.209). At 2 years, the MACE rate was EPC 13.7%, CURA 15.1%, and BMS 19.7% (P = 0.383). Target vessel revascularizations (TVR) were EPC 4.2%, CURA 9.4%, and BMS 6.0% (P = 0.439). Nonfatal myocardial infarctions were EPC 1.1%, CURA 3.8%, and BMS 4.1% (P = 0.364). One patient in the EPC group had acute stent thrombosis. There was no late stent thrombosis in the EPC group.
Conclusion: EPC stent appeared to be safe and had comparable clinical efficacy with a BMS when used in the AMI setting. At 2‐year follow‐up, the EPC group showed favorable, single‐digit TVR rate and stent thrombosis remained a low‐event occurrence. (J Interven Cardiol 2010;23:101‐108)
Central nervous system involvement in diffuse large B‐cell lymphoma
Authors: Yamamoto Wataru , Tomita Naoto , Watanabe Reina , Hattori Yukako , Nakajima Yuki , Hyo Rie , Hashimoto Chizuko , Motomura Shigeki , Ishigatsubo Yoshiaki 
Published: March 2010

Abstract Background: Malignant lymphoma with central nervous system (CNS) involvement has an extremely poor prognosis. We retrospectively studied the risk factors for CNS involvement in patients with diffuse large B‐cell lymphoma (DLBCL) treated by cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP) or rituximab (R) ‐CHOP chemotherapy. Patients and methods: We studied 375 consecutive patients who were newly diagnosed with DLBCL between 1996 and 2006. Patients with primary CNS involvement and patients who received CNS prophylaxis were excluded. All the patients received CHOP (n = 172) or R‐CHOP (n = 203) chemotherapy. The following variables were assessed for their potential to predict CNS involvement: gender, age, serum lactate dehydrogenase (LDH) level, performance status, clinical stage, number of extranodal involvements, International Prognostic Index (IPI), bone marrow involvement, presence of a bulky mass, presence of B symptom, and treatment. Results: CNS involvement was observed in 13 cases (3.5%). In univariate analysis, LDH more than normal range, LDH more than twice as normal range, high IPI, bone marrow involvement, and systemic relapse were the predictors for CNS involvement. In multivariate analysis, no risk factors were detected for CNS involvement. The use of rituximab did not have an impact on CNS involvement. Conclusions: The incidence of CNS involvement dose not decrease in rituximab‐era.
Frailty vs. Disability Distinctions in People With Intellectual Disabilities
Authors: Brehmer Barbara , Weber Germain 
Published: March 2010

AbstractWhile the extent of research on age‐related frailty among adults in general has increased substantially during the past two decades, there has been a void in equivalent research with respect to adults with intellectual disabilities (ID). While frailty and disability have been seen as different, but overlapping, concepts in the field of ID, the concept of frailty is missing an empirical foundation. The authors define the concept of frailty as applied to adults with ID, using indicators based on Fried's definition (i.e., a physiological state of increased vulnerability to stressors that follows from decreased physiological reserves and dysregulation of a physiological system) and Rockwood's frailty criteria (multisystemic instability, change over time, allowance for heterogeneity, association with aging, and association with an increased risk of adverse outcomes). They developed a frailty questionnaire and tested their concept of frailty against the concept of disability. To do this, frailty‐related data using self‐report and third‐party interviews were collected within the Austrian component of the POMONA II Project using a sample of 190 people with ID aged between 18 and 76 years. Variables in four frailty domains—social, cognitive, physical, and mental health—were assessed and defined as contributing to causal frailty factors. Similarities of the frailty syndrome were analyzed between the general population and the population with ID. The results offer evidence of a “frailty syndrome” affecting older people with ID.
Sexual Experiences of Men with Incontinent Partners
Authors: Bekker Milou D. , Beck Jacky J.H. , Putter Hein , Van Driel Mels F. , Pelger Rob C.M. , Weijmar Schultz Willibrord C. , Lycklama à Nijeholt Guus A.B. , Elzevier Henk W. 
Published: March 2010

ABSTRACT

Introduction
Several studies show that urinary incontinence (UI) impairs women’s sexual functioning and sexual satisfaction. However, there is no scientific knowledge about the effects of UI on sexual functioning of the male partners.

Aim
To analyze sexual functioning of the male partners of females with UI.

Methods
During a period of 2.5 years all new female patients and their partners (both groups aged 18 years and older), who presented at our outpatient clinic for urological evaluation, were asked for demographic characteristics, medical history, and referral indication including the main urological complaint. In addition they were asked to fill in the Golombok Rust Inventory of Sexual Satisfaction questionnaires about sexual functioning.

Main Outcome Measures
Sexual function measured by the Golombok Rust Inventory of Sexual Satisfaction questionnaire.

Results
A total of 189 sexually active couples completed the questionnaires. Eighty-one (42.9%) of the women had UI as main urological complaint. Differences were found between women with UI and those without. Women with UI have a lower overall sexual function (P = 0.02), lower frequency of intercourse (P = 0.02), more problems with communication (P = 0.036), and more often show avoidable behavior with regard to sexual activity. (P = 0.002) Men with partners with UI showed a diminished overall sexual function (6.66 ± 1.53) compared with men with women without UI (5.95 ± 1.22, P = 0.001). Furthermore, comparisons of subscales also demonstrate a lower frequency of intercourse (5.62 ± 2.00, 6.49 ± 1.96), less satisfaction (8.08 ± 2.79, 9.69 ± 3.63), and more erectile problems (6.01 ± 2.28, 6.87 ± 3.23) in men with partners with UI. (P = 0.03, P = 0.001, P = 0.037)

Conclusions
This study shows that female urinary incontinence correlates with their partners’ overall sexual functioning and sexual satisfaction. In addition, significant differences were found with regard to the satisfaction with one’s sex life between a woman with UI and her partner.
Is One Question Enough to Detect Female Sexual Dysfunctions? A Diagnostic Accuracy Study in 6,194 Women
Authors: Kriston Levente , Günzler Cindy , Rohde Anke , Berner Michael M. 
Published: March 2010

ABSTRACT

Introduction
Literature shows that recognition of sexual dysfunctions in women is insufficient and existing instruments to aid detection are mostly too extensive to be used in routine practice.

Aim
To develop a brief and accurate screening instrument to detect female sexual dysfunctions in routine care.

Methods
The initial item pool for the index test consisted of 15 items. In a 4-year period, a total of 12,957 persons filled out the test on a specifically designed web-site. Six thousand one hundred ninety-four complete data sets could be used for statistical analysis. The validated German version of the Female Sexual Function Index (FSFI-d) served as reference standard to estimate the accuracy of the screening test. In order to test several possible ways of combining items a multi-step procedure employing univariate analyses, multiple logistic regression, and classification and regression tree analysis was applied to a learning sample and cross-validated in a test sample.

Main Outcome Measures
Diagnostic performance (sensitivity, specificity, positive and negative predictive value, accuracy, diagnostic odds ratio as well as adjusted odds ratio) of the items and resulting models to discriminate women with sexual dysfunction from those without were calculated.

Results
One dichotomous question for overall satisfaction proved to show high accuracy as a stand-alone instrument and played also a central role in multivariate models. It may be recommended as a one-question screening test (76.4% sensitivity and 76.5% specificity in the test sample). A hierarchical two-question test yielded higher sensitivity (93.5%) and lower specificity (60.1%). A slightly more extensive version consists of five questions (83.1% sensitivity and 81.2% specificity).

Conclusions
Despite some methodological limitations of our study all developed tests showed acceptable to good diagnostic performance, all are very short and could therefore be easily implemented into routine care. Further tests of psychometric properties in other settings are needed.
INFLUENCE OF ACID ADAPTATION ON THE SURVIVAL OF SALMONELLA ENTERITIDIS AND SALMONELLA TYPHIMURIUM IN SIMULATED GASTRIC FLUID AND IN RATTUS NORVEGICUS INTESTINE INFECTION
Authors: PEREZ KARLA JOSEANE , CECCON RAQUEL VALIM , DA SILVA MALHEIROS PATRÍCIA , JONG ERNA VOGT , CESAR TONDO EDUARDO 
Published: March 2010

ABSTRACT The aim of this study was to investigate the influence of acid adaptation in the survival of Salmonella Enteritidis (SE86) and Salmonella Typhimurium (ST99) during exposure to simulated gastric fluid (SGF) and in intestinal infection of Rattus norvegicus. Acid‐adapted and nonadapted Salmonella strains were exposed to SGF (pH 1.5) and were inoculated by gavage in adult rats. Results indicated that acid‐adapted SE86 survived significantly better (P < 0.05) than nonadapted SE86, nonadapted ST99 and acid‐adapted ST99 in SGF. Nonadapted microorganisms were observed in higher counts in feces than acid‐adapted strains, while acid‐adapted microorganisms demonstrated higher counts in intestine samples, suggesting intestinal invasion capacity. Acid‐adapted SE86 was recovered in higher counts from ileum‐cecum junction than the other microorganisms.PRACTICAL APPLICATIONS Salmonella Enteritidis has been identified as the most frequent serovar involved with the foodborne outbreaks in Brazil. In Southern Brazil, a specific strain of Salmonella Enteritidis (SE86) has been involved with more than 90% of the salmonellosis occurring in the last years, and the main food vehicle is home‐made mayonnaise frequently added with different quantities of vinegar, which can cause acid adaptation in Salmonella cells. The results of this work indicate that SE86 presented higher acid adaptation, which contributed to higher survival rates in simulated gastric fluid and better intestinal colonization. These results could be related to human virulence and the frequent involvement of this strain with foodborne outbreaks in southern Brazil.
HYGIENE PERCEPTION: CONDITION OF HOTEL KITCHEN STAFFS IN ANKARA, TURKEY
Authors: SANLIER NEVIN , CÖMERT MENEKSE , DURLU‐ÖZKAYA FUGEN 
Published: March 2010

ABSTRACT The study, which analyzed knowledge levels of the staff who work in food and beverage departments of hotels in Turkey about food safety, was carried out in December 2007–March 2008. Researchers applied face to face survey to 522 employees of seven hotels. The difference has been found meaningful statistically between kitchen and kitchenware hygiene, employee hygiene, food hygiene and general hygiene knowledge points and their education status and occupations in the result of the study (P < 0.05). On the other hand, a meaningful relationship has not been found statistically between food safety knowledge levels of the staff and their age ranges (P > 0.05). First, it is required to pay attention to the determining of the training needs of employees working for the enterprise, and to make a point of applying necessary training and seminars concerning the staff in each degree by making a training program. It has been determined that training, occupation and experience of the staff are so important in order to provide food safety in enterprises.PRACTICAL APPLICATIONSEach year, millions of people worldwide suffer from foodborne diseases and illnesses. Therefore, food‐related infection is an important health problem in many countries. This study analyzed the knowledge levels of employees who work in the food and beverage departments. It has been found that there is a need to develop a state policy regarding education to be given to consumers and employees about food safety knowledge and practices. Education should be repeated with specific intervals to ensure that learnt information is turned into attitudes and behaviors; and procedures and processes should be controlled regularly.
INFLUENCE OF INTESTINAL SURFACTANT LIKE PARTICLES ON DIFFERENTIAL ACTIVATION OF SECONDARY SIGNALING MOLECULES DURING SALMONELLA TYPHIMURIUM INFECTION
Authors: SOFI M. HANIEF , BHATNAGAR ARCHANA , SAPRA SAVEETA , MAHMOOD AKHTAR , MAJUMDAR SIDHARTHA 
Published: March 2010

ABSTRACT Interaction between the enteric pathogen Salmonella typhimurium and the luminal surface of the intestine provoke an acute inflammatory response mediated in part by various inflammatory molecules. Surfactant‐like particles (SLP) are known to cover the surface of the intestinal epithelium, act as lubricants and/or as a vehicle to deliver digestive enzymes to the luminal fluid. Recently we have shown that SLP plays an important protective role during microbial insult. The data suggested that SLP‐induced diet prevents the damage of intestinal villi caused by S. typhimurium infection. The present study was designed to assess the role of SLP on secondary signaling molecules during S. typhimurium infection. The Peyer's patch, intraepithelial and lamina propria mononuclear cells were analyzed under various conditions for secondary signaling molecules, including calcium, inositol triphosphate and protein kinase C. SLP‐induced diet along with infection showed significant variation in these secondary signaling molecules, particularly in Peyer's patches, as compared to infection group alone. In addition, the cells isolated from the infected group upon incubation in vitro with SLP also showed a considerable variation of these molecules. These results suggested an important influence of SLP on secondary signaling molecules and, in turn, could be important in overall immune modulation during infection.PRACTICAL APPLICATIONS Salmonella are known to cause disease in humans, animals and birds worldwide. Over 1.4 million cases of salmonellosis (gastroenteritis) per year occur in the U.S.A. and other industrialized countries. Countries with poor sanitation have a much higher incidence of salmonellosis. The disruption of epithelial barrier integrity by Salmonella has pathological consequences. Intestinal epithelium secretes surfactant‐like particles (SLP); these particles have the ability to cover the surface of the cell in the intestinal lumen. They are known to have ability in binding of uropathogenic Escherichia coli and in protecting the disruption of intestinal villi. The present study provides further evidence for its role in regulating secondary signaling molecules and overall immune response. SLP induced by dietary fat enhanced the resistance to intestinal infections, as it possibly decreases the colonization and translocation of S. typhimurium. The SLP and microbe interaction may thus represent a delicate balance between symbiosis and pathogenesis.
The Carnal Body: Representation, Performativity and the Rest of Us
Authors: Detamore Mathias J. 
Published: March 2010

AbstractThe body has long been a concern of human knowledge; where it comes from, how it develops, how it works, what it means. Since the feminist political activism and academic scholarship of the late 1960s, at least, the body has had a resurging interest in the social sciences and humanities as a location through which Enlightenment notions of a mind/body dichotomy have held the female body captive. Out of this, how the body is ‘represented’ and how the body is ‘performed’ through the ways in which we talk about ourselves has theoretically pushed the body to the fore in much academic thought and inquiry. While gender and (soon following) sexuality has been the primary impetus for reevaluating the body and its relationship to power, the body can now be found in an array of other socio‐political phenomena that render the body a site for exclusion, violence and marginality. Yet the elusiveness of the body and its difficulty at definition continues to provoke anxiety in scholars working through its problems. A recent contribution on ‘carnality’ seems to offer us a window into a more refined and nuanced understanding of the body, highlighting the inseparable interdependence between the corporeal material of the body and the subjective discourses that ‘matter forth’ the body. This essay examines the location of the body in geographical literatures and the social sciences and humanities by briefly outlining its (re)emergence in feminist literatures; locating its continuing development in geographical literatures; taking it through one particular prevailing theoretical debate (including a major geographical intervention through the work of Nigel Thrift); and supposing my own intervention working through Elizabeth Povinelli’s concept of ‘carnality’.
The New Geopolitics of Fear
Authors: Pain Rachel 
Published: March 2010

AbstractThis century, linked to a series of geopolitical events and phenomena, an array of new fears have come to prominence. A number of academic and popular commentators have named and analysed these fears and predicted their reach and effects on people in western countries. However, these accounts have often lacked grounding in evidence that is mounting elsewhere on the everyday sites where emotions and geopolitics meet. This paper brings together a range of evidence from social research about western fears connected to the war on/of terror. First, through examining survey evidence since 2001, I suggest that fear of terrorism in the west tends to be overblown by commentators, and that fear close to the sites of terrorism should be viewed as exceptional rather than routinised or dispersed. Second, I explore a growing body of research that shows those most affected by fear in the current geopolitical climate are marginalised minority groups. Finally, I identify recent writing on alternative geopolitics which points to some original and hopeful directions for conceptual and empirical work on fear.
Methodological Approaches for Interviewing Elites
Authors: Harvey William S. 
Published: March 2010

AbstractThis paper explores some of the methodological strategies for interviewing elites. The focus is on researching elite members, preparing for interviews and gaining access, as well as the associated power relationships. Examples are drawn from across the social sciences and from the author’s doctoral and postdoctoral work with over one hundred members of business elites. It is argued that researchers should be more attentive towards the following three areas. First, providing flexibility when designing research projects and conducting interviews. Second, ensuring transparency when communicating with elite members. Third, maintaining good etiquette with all participants to ensure the highest professional standards. The overall aim of the paper is to provide an introduction for those who are new to the field of interviewing elite subjects.
Lumped Conceptual Rainfall‐Runoff Models and Simple Water Balance Methods: Overview and Applications in Ungauged and Data Limited Regions
Authors: Chiew Francis H. S. 
Published: March 2010

AbstractThis article provides an overview of lumped conceptual rainfall‐runoff models and simple water and energy balance methods, with a focus on practical model applications to estimate runoff in gauged and ungauged catchments over large regions and to predict climate change impact on future runoff. The models are applied to a large data set across south‐eastern Australia to explore the effectiveness of the different model types under varying data availability. The conceptual rainfall‐runoff models are relatively simple tools for predicting runoff in catchments and large regions with sufficient observed streamflow data to calibrate the models. In data‐poor regions, the simple water balance methods can perform as well as the rainfall‐runoff models, particularly where only mean annual runoff estimates for broad‐scale assessments are required. Rainfall‐runoff modelling is a fairly mature science, and this article provides references to previous reviews and recent key papers, particularly on regionalisation studies to predict runoff in ungauged catchments. The study also discusses some of the more significant research areas currently being pursued as well as the use of lumped conceptual rainfall‐runoff models for climate change and land use impact studies.
Syntrophic butyrate and propionate oxidation processes: from genomes to reaction mechanisms
Authors: Müller Nicolai , Worm Petra , Schink Bernhard , Stams Alfons J. M. , Plugge Caroline M. 
Published: March 2010

SummaryIn anoxic environments such as swamps, rice fields and sludge digestors, syntrophic microbial communities are important for decomposition of organic matter to CO2 and CH4. The most difficult step is the fermentative degradation of short‐chain fatty acids such as propionate and butyrate. Conversion of these metabolites to acetate, CO2, formate and hydrogen is endergonic under standard conditions and occurs only if methanogens keep the concentrations of these intermediate products low. Butyrate and propionate degradation pathways include oxidation steps of comparably high redox potential, i.e. oxidation of butyryl‐CoA to crotonyl‐CoA and of succinate to fumarate, respectively, that require investment of energy to release the electrons as hydrogen or formate. Although investigated for several decades, the biochemistry of these reactions is still not completely understood. Genome analysis of the butyrate‐oxidizing Syntrophomonas wolfei and Syntrophus aciditrophicus and of the propionate‐oxidizing Syntrophobacter fumaroxidans and Pelotomaculum thermopropionicum reveals the presence of energy‐transforming protein complexes. Recent studies indicated that S. wolfei uses electron‐transferring flavoproteins coupled to a menaquinone loop to drive butyryl‐CoA oxidation, and that S. fumaroxidans uses a periplasmic formate dehydrogenase, cytochrome b:quinone oxidoreductases, a menaquinone loop and a cytoplasmic fumarate reductase to drive energy‐dependent succinate oxidation. Furthermore, we propose that homologues of the Thermotoga maritima bifurcating [FeFe]‐hydrogenase are involved in NADH oxidation by S. wolfei and S. fumaroxidans to form hydrogen.