bluuebunny/crossref_metadata_2025_split huggingface dataset:
Experimentelle und theoretische Untersuchungen zum Hochtemperaturverhalten von Feinbeton und Textilgarnen
Authors: Kulas Christian , Hegger Josef , Raupach Michael , Antons Udo 
Published: October 2011

AbstractDie Einhaltung von Brandschutzanforderungen ist ein wichtiger Aspekt für sichere Baukonstruktionen. Beim innovativen Werkstoff textilbewehrter Beton, der einen Verbundwerkstoff aus textiler Bewehrung und einer Feinbetonmatrix darstellt, ist das Brandverhalten bisher nur unzureichend erforscht worden. Insbesondere das Tragverhalten der einzelnen Komponenten unter hohen Temperaturen stellt noch eine Wissenslücke in der heutigen Forschung dar. Dieser Aufsatz befasst sich mit den experimentellen Untersuchungen an einer Feinbetonmatrix, die einen Größtkorndurchmesser von 0,6 mm aufweist, sowie an AR‐Glas‐ und Carbongarnen. Basierend auf instationären Versuchen werden das Spannungs‐ und Dehnungsverhalten unter hohen Temperaturen abgeleitet und Ansätze zur rechnerischen Beschreibung vorgeschlagen.Experimental and theoretical investigations on the high‐temperature behavior of fine‐grained concrete and textile yarnsThe design of structural members under fire attack is an important aspect for safe constructions. For the innovative material textile reinforced concrete (TRC), which is a composite material made of fine‐grained concrete and textile reinforcement, the fire behavior has not been investigated intensely yet. Especially the load‐bearing behavior of the single components under hightemperature marks a gap in the state‐of‐the‐art of science and technology today. This article deals with experimental investigations on a fine‐grained concrete matrix, which has a maximum grain size of only 0.6 mm, as well as yarns made of ARglass and carbon. On the basis of transient tests the stress and strain behavior under high temperatures is derived. Finally, a calculative approach for the high‐temperature behavior is suggested.
Bemessung der Lastdurchleitung hochfester Stahlbetonstützen durch normalfeste Flachdecken nach EN 1992‐1‐1
Authors: Cyllok Michael 
Published: October 2011

AbstractIn Deckenknoten können Kräfte aus hochfesten Stützen durch normalfeste Flachdecken hindurchgeleitet werden, wenn die Knoten hierfür bemessen und ausgelegt werden. Zurzeit liegen jedoch weder in den in Deutschland eingeführten technischen Baubestimmungen noch in den mit Einschränkung von der Bauaufsicht ebenfalls akzeptierten Eurocoderegelungen direkte Bemessungsansätze für solche Deckenknoten vor. Im vorliegenden Aufsatz wird daher ein Bemessungsmodell für hochbelastete Deckenknoten vorgestellt, welches Regelungen zu Stabwerken, Teilflächenbelastung und mehraxialen Druckspannungszuständen nach DIN EN 1992‐1‐1 kombiniert. Dieses Bemessungsmodell wird an ausgewählten Laborversuchen validiert und soll es ggf. nach weiteren Validierungen ermöglichen, hochbelastete Deckenknoten sicher und bauordnungskonform ohne Zulassungen oder Zustimmung im Einzelfall zu bemessen.Transmission of forces of high strength concrete columns through normal strength flat slabs – design according to EN 1992‐1‐1A specially designed slab column joint can transmit forces of high strength columns trough normal strength flat slabs. Presently none of the in Germany officially acknowledged codes for structural engineering (including the Eurocodes) provide with direct design rules for those slab column joints. Hence, this article presents a design method for highly loaded slab column joints which combines rules for strut and tie models, partially loaded areas and confined concrete according to DIN EN 1992‐1‐1. This design method is validated with selected tests and could enable the engineer to design highly loaded slab column joints on the basis of officially acknowledged codes.
Innovative Verbundmittel in Ultrahochleistungsbeton
Authors: Wiese Susanne , Schnell Jürgen , Kurz Wolfgang 
Published: October 2011

AbstractDie Entwicklung von Ultrahochleistungsbeton eröffnet zahlreiche neue Anwendungs‐ und Konstruktionsmöglichkeiten. Insbesondere im Verbundbau lassen sich die Werkstoffe Stahl und UHPC gemäß ihren materialspezifischen Vorteilen optimal kombinieren. Die Erforschung von UHPC wird in dem von der DFG initiierten Schwerpunktprogramm SPP 1182 vorangetrieben. Im Zuge dieses Programms werden in einem Projekt an der TU Kaiserslautern filigrane Verbundträger mit dünnen UHPC‐Gurten und einem neu entwickelten Verbundmittel untersucht. Im vorliegenden Beitrag werden die erzielten Ergebnisse vorgestellt. Zunächst werden das Verbundmittel “Stahlschare” vorgestellt und die experimentellen und numerischen Untersuchungen zur Analyse der Beanspruchungen aus dem Herstellprozess gezeigt. Versuche zur Längsschubtragfähigkeit in Form von Push‐out‐Versuchen gaben Aufschluss über das Trag‐ und Verformungsverhalten und führten zu einem Bemessungsansatz für das Versagenskriterium Stahlversagen. Daneben wurde ein FE‐Modell entwickelt, um weitergehende Erkenntnisse zu den Lastabtragungsmechanismen zu gewinnen.Innovative shear connectors in ultra high performance concreteThe development of ultra high performance concrete offers various fields of applications. Especially in composite structures the materials steel and concrete can be ideally combined corresponding to their specific material properties. Research on UHPC is forwarded by the research programme SPP 1182 initiated by the DFG. In a project of this programme filigree composite girders with thin UHPC‐slabs and a novel shear connector are investigated at the University of Kaiserslautern (TU). The following article presents the achieved results. At first the shear connectors “steel shares” are introduced and the experimental and numerical investigations on the strains resulting from the fabrication process are shown. Tests on the longitudinal load bearing capacity gave information about load bearing and deformation capacity and led to a design approach for the criterion of steel failure. Additionally a FE‐model was built up in order to get further insights in the load transfer mechanisms.
Lyoluminescence, thermoluminescence and mechanoluminescence studies in γ‐ray irradiated Dy3+ activated potassium chloride phosphor for accidental radiation dosimetry
Authors: Bhujbal P. M. , Dhoble S. J. 
Published: October 2011

ABSTRACTThe lyoluminescence (LL), thermoluminescence (TL) and mechanoluminescence (ML) of γ‐ray‐irradiated coloured powder of KCl:Dy (0.05–0.5 mol%) phosphors are reported in this paper. To understand the mechanism of LL and ML, the LL and ML spectra are compared with TL studies. The variation of intensity of respective luminescence with different γ‐ray doses and with different concentrations of Dy3+ ion doped in KCl is found to be similar in nature. The intensities differ from each other, but their nature is found to be similar with γ‐ray exposures. The ML glow peak intensity is linear up to high 1 kGy exposure as compared to LL (up to 0.5 kGy) and TL (up to 0.75 kGy) techniques. Therefore, according to our results, the recommendation is that KCl:Dy (0.1 mol%) phosphor prepared by wet chemical technique is useful for high‐dose measurements using the ML technique for accidental radiation dosimetry. Copyright © 2011 John Wiley & Sons, Ltd.
Transcatheter aortic valve replacement in a patient with an anomalous origin of the right coronary artery
Authors: Weich Hellmuth , Ackermann Christelle , Viljoen Hofmeyr , van Wyk Jacques , Mabin Thomas , Doubell Anton F. 
Published: October 2011

AbstractWe describe the first case of implantation of a transcatheter aortic valve implantation (TAVI) in a patient with an anomalous origin of the right coronary artery, coursing in between the aorta and pulmonary truncus to the right. After assessment of the risk of compression of the anomalous origin of the right coronary artery from the left coronary sinus (ARCA), the procedure was performed without complication. A brief discussion of the pathophysiology of ARCA is provided and the implications for TAVI as well as our recommendations are offered.© 2011 Wiley Periodicals, Inc.
Intensive statin therapy for Chinese patients with coronary artery disease undergoing percutaneous coronary intervention (ISCAP study)
Authors: Liu Peng , Jiang Jie , Li Jianping , Hong Tao , Zhang Yan , Yu Ronghui , Jia Jia , Huo Yong 
Published: October 2011

AbstractBackground: Myocardial necrosis is related to higher incidence of cardiovascular events and higher mortality rates during follow‐up. Statins have been demonstrated to lower the risk of periprocedural myocardial infarction. The aim of this study is to evaluate the safety and efficacy of intensive statin therapy and the long‐term outcome of patients in the Asian population. Study design: Approximately 1,100 patients with stable angina or non‐ST elevation acute coronary syndrome undergoing selective percutaneous coronary intervention (PCI) are enrolled in this study. Patients are randomized either to the experimental group (80 mg atorvastatin 80 mg/day × 2 days before and 40 mg/day × 30 days after PCI) or to the control group (usual care). Creatine kinase‐MB (CK‐MB), troponin I (cTnI), and serum creatine are measured at 24 hours after the procedure. The total follow‐up period is 6 months. The primary objective is to evaluate the efficacy of intensive atorvastatin treatment compared with usual care in reducing 30‐day primary cardiovascular endpoints in patients undergoing selective PCI. Secondary endpoints are changes in myocardial biomarkers (cTnI, CK‐MB) and hs‐CRP, CIN morbidity, 6‐month clinical outcomes, and safety. Conclusion: The result of the ISCAP study will provide important evidence on the efficacy and safety of periprocedural serial intensive statin treatment in Asian patients with coronary artery disease undergoing selective PCI. © 2011 Wiley Periodicals, Inc.
Performance of valve‐in‐valve for severe para‐prosthetic leaks due to inadequate transcatheter aortic valve implantation
Authors: Napodano Massimo , Gasparetto Valeria , Tarantini Giuseppe , Fraccaro Chiara , Yzeiraj Ermela , Gerosa Gino , Isabella Giambattista , Iliceto Sabino 
Published: October 2011

AbstractObjectives: This study reports on mid‐term safety and performance of valve‐in‐valve implantation as rescue strategy to overcome acute PPL after TAVI. Background. Moderate to severe para‐prosthetic leaks (PPL) after transcatheter aortic valve implantation (TAVI) have been described with both self‐expandable and balloon‐expandable device.Methods: We analyzed data regarding patients who underwent valve‐in‐valve implantation, enrolled in the ongoing single‐center prospective registry of TAVI, the Padova University REVALVing experience Registry. All procedures were performed by a totally percutaneous approach, using the self‐expanding Medtronic CoreValve (Medtronic, Minneapolis, MN). Results: Out of 87 patients who underwent TAVI, six received valve‐in‐valve implantation because of persisting severe PPL, due to prosthesis malposition. In all patients, the second device was successfully deployed, with a significant reduction in aortic regurgitation: PPL was no longer appreciable in two of six patients, and it decreased from severe to mild or trivial in four patients. Four patients developed atrio‐ventricular block requiring pace‐maker implantation. At follow‐up (6–24 months) two patients died, whereas no prosthesis‐related death occurred. Transprosthesis pressure gradient, effective orifice area, and aortic regurgitation did not change at serial echocardiograms throughout the follow‐up. Conclusions: Valve‐in‐valve implantation using self‐expandable bioprosthesis seems safe and highly effective to overcome severe PPL due to prosthesis malposition early after TAVI. Moreover, the implantation of two valves does not affect the performance of prosthesis at follow‐up. © 2011 Wiley Periodicals, Inc.
Synthetische Biologie
Authors: Weitze Marc‐Denis 
Published: October 2011

AbstractIn Fortführung von Verfahren der Gentechnik und Molekularbiologie verfolgt die Synthetische Biologie einen ingenieurwissenschaftlichen Ansatz, indem sie auf verschiedenen Ebenen (Gene, Stoffwechselwege, Zellen) in biologische Prozesse eingreift oder diese ganz neu konstruiert. Man verspricht sich kostengünstigere biotechnologische Verfahren mit besonders reinen Produkten. Das noch junge Feld wirft aber auch ethische, rechtliche und gesellschaftliche Fragen auf.
Die Brüder Otto und Robert Margulies
Authors: Offermanns Heribert , Becker Frank , Wipfler Helmut 
Published: October 2011

AbstractAmmoniak und Wasserstoffperoxid, bedeutende Industriechemikalien mit einer Weltproduktion von rund 125 bzw. 3, 5 Mio. Tonnen, sind für die Produktion von Düngemitteln bzw. für Oxidationen unerlässlich. Gleichwohl sucht man in diesem Zusammenhang den Namen Margulies in Lexika, Enzyklopädien, Hand‐ und Sachbüchern vergeblich. Denn es ist weitgehend unbekannt, dass die Brüder Dr. Otto und Dr. Robert Margulies, Söhne des bedeutenden österreichischen Chemieunternehmers Benedikt Margulies, als Visionäre die Bedeutung der Katalyse und der Elektrochemie als Basistechnologien voraussahen. Als Pioniere der Industriellen Chemie haben sie die Fixierung des Stickstoffs aus der Luft angeregt und die erste technische Synthese von Wasserstoffperoxid realisiert.
Neue Anschrift: (H2O)1@C60
Authors: Jaenicke Lothar 
Published: October 2011

AbstractDas Wasser, H2O, das wir um uns herum kennen, sei es im festen, flüssigen oder gasförmigen Aggregatzustand, ist immer “polymeres” (H2O)n mit n von mindestens 4 (Tetraeder in heißem Dampf) bis “sehr, sehr groß” (Eis), zusammengehalten durch Wasserstoffbindungen zwischen der Lewisbase O: und den Lewissäuren H+, die sich in alle drei Raumdimensionen erstrecken und mit der Zeitdimension dynamisch in allen Richtungen oszillieren können. Es ist also turbulentes Geschehen in einem Tropfen Wasser, das ihn als Lösemittel und Stabilisator für Stoffe sowie als chemischen und physikalischen Reaktionspartner so vielfältig macht, wie die Bibliotheken, die bereits darüber geschrieben wurden.
Regulation des alternativen Spleißens
Authors: Hille‐Rehfeld Annette 
Published: October 2011

AbstractDurch alternatives Spleißen der primären Transkripte (Prä‐messengerRNA) kann die Vielfalt der Proteine eines Organismus erhöht werden. Als Regulator beim Erkennen und Verwenden alternativer Spleißstellen rückte jetzt das Ubiquitin‐ähnliche Protein Hub1 ins Rampenlicht.
Arsen
Authors: Schwedt Georg 
Published: October 2011

AbstractDas seit fast 200 Jahren bestehende Mineralogische Museum der Universität Bonn, das 1874 eine bedeutende Sammlung vom Gründer des heutigen Rheinischen Mineralien‐Kontors A. Krantz erhielt, zeigt unter anderem systematisch geordnet Minerale zu ausgewählten chemischen Elementen. Sie werden in dieser Serie zum Internationalen Jahr der Chemie 2011 näher vorgestellt.
Disillusionment from Failure as a Source of Successful Learning
Authors: Cusin Julien 
Published: October 2011

AbstractIn this article I review the literature on organizational learning from failed product launches. I challenge the view that failure is an inevitable part of the “probe and learn” process as well as the view that companies do not learn anything from such failures. I conclude there is no direct link between learning and commercial failures, and highlight many obstacles that hamper the learning process. Finally, even when learning does occur, it will not always result in improved organizational performance. Copyright © 2011 ASAC. Published by John Wiley & Sons, Ltd.
Les désillusions de l'échec comme source d'apprentissage performant
Authors: Cusin Julien 
Published: October 2011

AbstractIn this article I review the literature on organizational learning from failed product launches. I challenge the view that failure is an inevitable part of the “probe and learn” process as well as the view that companies do not learn anything from such failures. I conclude there is no direct link between learning and commercial failures, and highlight many obstacles that hamper the learning process. Finally, even when learning does occur, it will not always result in improved organizational performance. Copyright © 2011 ASAC. Published by John Wiley & Sons, Ltd.
Nonlinear displacement of ventral stress fibers under externally applied lateral force by an atomic force microscope
Authors: Hakari Tomoro , Sekiguchi Hiroshi , Osada Toshiya , Kishimoto Kikuo , Afrin Rehana , Ikai Atsushi 
Published: October 2011

AbstractActin‐based stress fibers (SFs) have fundamental importance in the maintenance of mechanical stability of living cells. Several in vitro measurements of their elastic properties have therefore been made, but direct mechanical manipulation of individual SFs in vivo for the determination of their mechanical properties has not been attempted. No less important is a search for the possible formation of a global mechanical network involving SFs and other intracellular filamentous components. In this article, we present an application of atomic force microscopy to probe into a live cell and laterally push selected SFs in a fibroblast cells (VNOf 06 fibroblast‐like cells derived from rat vomeronasal tissue) transfected with a green fluorescent protein‐β‐actin gene. The transfected cells were transferred to a serum‐depleted medium before the atomic force microscope manipulation. The lateral displacement of the SFs under a point loading condition recorded on a fluorescence microscope revealed both linear and nonlinear displacements against the contour distance from the point of force loading. The nonlinear displacements of the SFs were attributed to their association with a cortical actomyosin–cell membrane complex that effectively pulled them back as a 2D thin plate. © 2011 Wiley Periodicals, Inc.
Model reduction techniques for fast blood flow simulation in parametrized geometries
Authors: Manzoni Andrea , Quarteroni Alfio , Rozza Gianluigi 
Published: October 2011

SUMMARYIn this paper, we propose a new model reduction technique aimed at real‐time blood flow simulations on a given family of geometrical shapes of arterial vessels. Our approach is based on the combination of a low‐dimensional shape parametrization of the computational domain and the reduced basis method to solve the associated parametrized flow equations. We propose a preliminary analysis carried on a set of arterial vessel geometries, described by means of a radial basis functions parametrization. In order to account for patient‐specific arterial configurations, we reconstruct the latter by solving a suitable parameter identification problem. Real‐time simulation of blood flows are thus performed on each reconstructed parametrized geometry, by means of the reduced basis method. We focus on a family of parametrized carotid artery bifurcations, by modelling blood flows using Navier–Stokes equations and measuring distributed outputs such as viscous energy dissipation or vorticity. The latter are indexes that might be correlated with the assessment of pathological risks. The approach advocated here can be applied to a broad variety of (different) flow problems related with geometry/shape variation, for instance related with shape sensitivity analysis, parametric exploration and shape design. Copyright © 2011 John Wiley & Sons, Ltd.
Application of partial‐filling capillary electrophoresis using lectins and glycosidases for the characterization of oligosaccharides in a therapeutic antibody
Authors: Yagi Yuki , Yamamoto Sachio , Kakehi Kazuaki , Hayakawa Takao , Ohyama Yukihito , Suzuki Shigeo 
Published: October 2011

AbstractOligosaccharides in therapeutic recombinant antibodies play important roles in regulation of various biological functions. To monitor the glycosylation profiles of antibody pharmaceuticals in the manufacturing process, a highly sensitive and specific method is required. We extended partial‐filling techniques using lectins and exoglycosidases in capillary electrophoresis for the characterization of 8‐aminopylene‐1,3,6‐trisulfonic acid labeled N‐linked oligosaccharides derived from the therapeutic antibody rituximab. In the lectin‐filling method, Galβ1–4GlcNAc‐specific Erythrina cristagali agglutinin, α1,6‐linked Fuc‐specific Aleuria aurantia lectin and Neu5Acα2–3Gal‐specific Maackia amurensis lectin were used. The oligosaccharides migrated through the lectin plug during separation; the changes in separation profiles were observed according to the interaction with the lectins. The glycosidase‐filling method allowed rapid digestion as suggested by the electropherograms. Partial‐filling CE methods can avoid tedious hands‐on procedures such as overnight incubation and optimization reaction condition with lectins and exoglycosidases. Combination of these partial‐filling capillary electrophoresis methods makes the characterization of oligosaccharide profiles of therapeutic antibodies easier and faster.
Further development of the rat Pig‐a mutation assay: Measuring rat Pig‐a mutant bone marrow erythroids and a high throughput assay for mutant peripheral blood reticulocytes
Authors: Kimoto Takafumi , Chikura Satsuki , Suzuki Kumiko , Kobayashi Xiao mei , Itano Yasuhiro , Horibata Katsuyoshi , Honma Masamitsu , Dobrovolsky Vasily N. , Heflich Robert H. , Miura Daishiro , Kasahara Yoshinori 
Published: October 2011

AbstractRecent studies indicate that the Pig‐a assay is a promising tool for evaluating in vivo mutagenicity. We have developed novel rat Pig‐a assays that facilitate measuring mutant frequencies in two early arising populations of blood cells, bone marrow erythroids (BMEs) and peripheral blood (PB) reticulocytes (RETs). In these assays, bone marrow cells of erythroid origin and PB red blood cells (RBCs) were identified using an antibody against rat erythroid‐specific marker HIS49. In addition, RETs were selectivity enriched from PB using magnetic separation of cells positive for CD71, a transferrin receptor expressed on the surface of BMEs and RETs, but not on the surface of mature RBCs. With magnetic enrichment, more than 1 × 106 CD71‐positive RETs could be evaluated by flow cytometry for Pig‐a mutant frequency within 5 to 8 min. CD59‐deficient RET and BME frequencies of more than 100 × 10−6 and 80 × 10−6 were detected 1 week after treating rats with 40 mg/kg N‐ethyl‐N‐nitrosourea; by comparison, the frequency of CD59‐deficient total RBCs in these rats was 13.2 × 10−6. The frequency of spontaneous Pig‐a mutant RETs and BMEs was less than 5 × 10−6 and 15 × 10−6, respectively. Since ∼98% of nucleated cells in the BME fraction were erythroblasts, it should be possible to use BMEs to determine the spectrum of CD59‐deficient Pig‐a mutations in cells of erythroid lineage. Conducting concurrent Pig‐a assays on RETs and BMEs may be useful for evaluating the in vivo mutagenicity of chemicals, especially when prolonged mutant manifestation is not feasible or when the confirmation of mutation induction is necessary. © Environ. Mol. Mutagen. 2011. Published 2011 Wiley‐Liss, Inc.