bluuebunny/crossref_metadata_2025_split huggingface dataset:
P02-171 - DAI scale Score and Verbal Expressed Satisfaction with Neuroleptic Treatment
Authors: Gomez-Bernal G. 
Published: June 2010

The aim of this study is to assess the verbal expressed satisfaction with neuroleptic treatment in thirty psychotic long-term inpatients. Verbal expressed satisfaction was compared with the results obtained in the DAI scale by the same psychotic inpatients.From all the participants in the psychoeducation group preformed in our centre 30 inpatients were randomly selected. As a pre-test of this group DAI scale is administered and patients are asked about the grade of satisfaction with the neuroleptic treatment received.A descriptive analysis of DAI scale scores and verbal expressed satisfaction is done and then Mc Nemar test is used to compare the percentage of satisfied patients with neuroleptic treatment using DAI scale and verbal expressed satisfaction. 30 psychotic inpatients were selected. Mean score in DAI scale was 15 points. Only 4 of the selected patients expressed an unfavourable opinion with the neuroleptic treatment received.A good verbal expressed satisfaction with the neuroleptic treatment was expressed according with scores obtained in DAI scale with no statistical differences in Mc Nemar test between both groups (p=0.22).
P02-173 - Family Mental Health and Adaptation
Authors: Gutkevich E.V. 
Published: June 2010

ObjectiveIdentification of dependence of dynamic of mental health of the family in the process of demographic reproduction with adaptive possibilities of family members.MethodsComplex investigation of 249 families of patients with mental disorders has been carried out revealing new forms of family and identification of qualitative and quantitative parameters of family interrelations with scale of family adaptation and cohesion FACES.ResultsPeculiarities of the contemporary family are as follows:1)family with one child predominates;2)number of birth beyond registered marriage increases;3)marriage consciously without children;4)process of nuclearization;5)open marriage;6)marital contract;7)alternative families emerge;8)number of lonely people and people consciously avoiding to get married increases.Families according to degree of cohesion have been divided into balanced - 69% and imbalanced - 31% of families. According to degree of adaptability there were 39% of balanced families, 61% - imbalanced. We observe variability of families. For real cohesion disconnected level is typical, for adaptation - chaotic style. Thus, concordance of real and ideal images about the family is absent. Thereby we have identified potential possibilities of the families. Most of them pass onto balanced level of cohesion (5 types of families in total), remaining at the level of chaotic forms of adaptation when there are conditions for changes.ConclusionMental health of the family at various stages of development of family system depends on adaptive possibilities.
P02-174 - Charles Bonnet Syndrome
Authors: Haj Kacem H. , Mnif L. , Masmoudi J. , Feki A. , Damak R. , Baati I. , Halwani N. , Ayadi N. , Jaoua A. 
Published: June 2010

The Charles Bonnet syndrome is characterized by the presence of complex visual hallucinations among elderly patients with ophthalmic disease previously free of any psychiatric disorder. It has long been considered rare because of the reluctance of patients for fear of being thought mentally ill.The objective of this work is to recognize the clinical characteristics of Charles Bonnet syndrome, allowing early detection and adequate care, through the presentation of two cases.The authors report two cases of elderly, free of any dementia, patients, with the result of an intervention on cataract complicated by a bilateral blindness. Charles Bonnet syndrome is revealed by complex visual and stereotyped hallucinations.These hallucinations exacerbated at night, disturbing the sleep of these patients.Only when the insomnia was associated with anxiety agitation, their respective families decided to make the patients consult the psychiatrist.The evolution under antipsychotic and antidepressant drugs was only partial.
P02-176 - Effects of Clozapine and its Metabolites on Expression of Glucose Transporter 2 Located in Cell Membrane of Isolated Rat's Islets
Authors: Liu H. , Ji C. , Xiao W. , Wang G. 
Published: June 2010

ObjectiveThe aim of this study was to clarify effects of Clozapine and its metabolites on insulin resection and expression of glucose transporter 2 (GLUT2) located in cell membrane of isolated rat's islets.MethodsThe cells of isolated rat's islets were prepared by a modified collagenase digestion methods. At 5.5 mmol/L glucose, the cells of islets was treated with 1mmol/L clozapine, desmethyl-clozapine(DCLO), clozapine N-oxide(CNO), respectively, blank control group was also set.1.After incubation 48h, the insulin in supernatant was assayed by radioimmunoassay.2.The cells of isolated rat's islets in each group were detected GLUT2 mRNA level with RT-PCR and its protein expression with Western-blot.Results1.Compared to control group, clozapine significantly inhibited insulin secretion (P=0.007< 0.01); DCLO has a tendency to inhibit insulin secretion after 48h of incubation, but no significant difference was found (P=0.154>0.05). There was no difference of insulin secretion between CNO group and the control group after 48h of incubation (P>0.05).2.The mRNA and protein expression of GLUT2 located in cell membrane of slets: clozapine group was significantly lower than control group (P=0.017< 0.05, P=0.035< 0.05), DCLO group was also lower than control group, but no significant difference was found (P>0.05), and no significant difference between CNO group and control group (P>0.05).ConclusionClozapine can inhibit GLUT2 expression of cells of islets, and then hamper glucose transport through cell membrane, which was one of mechanisms to explain the effect of clozapine on insulin secretion.
P02-178 - BMI Directly Relates to Glycaemia in Patients with Severe Enduring Mental Illness
Authors: Anderson S. , Narayanan R.P. , Hodgson R. , de Hert M. , Heald A. 
Published: June 2010

ObjectivesPeople with severe enduring mental illness (SMI) are at least twice as likely to die from cardiovascular disease (CVD) than the general population, with 60% of excess mortality rate attributable to physical illness.MethodsWe report implementation in primary care of screening and intervention for cardiometabolic risk factors in SMI in Cheshire, UK. Data search was performed through the EMIS software provider.Results453 patients (55.8% male 44.2% female) on the SMI Register in Cheshire, UK were screened for dysglycaemia (screening rate 57.3 %) and dyslipidaemia (screening rate 36.2%). There were no differences in BMI by gender, but a greater proportion of women (25% vs 20%) were obese (BMI ≥ 30 kg/m2). Fasting glucose was in the impaired fasting glycaemia range (6.1-6.9mM) in 6.5% of those screened and at or above the threshold for type 2 diabetes (7.0mM) in 17.3% of the group. Fasting serum cholesterol was high at >5mmol/L in 62.8% of those screened for whom the mean cholesterol was 6.2±0.8 mmol/L). Despite high rates of dysglycaemia and dyslipidaemia, systolic blood pressure was greater than 140mmHg in only 13% of those examined. 61% were active smokers.Multivariate linear regression analyses revealed a direct relation between fasting glucose levels and BMI (beta = 0.22, p< 0.001) independent of age, gender, systolic blood pressure and fasting cholesterol and triglycerides.ConclusionThere is scope for cardiometabolic risk reduction in patients with severe mental illness. Measures to encourage weight reduction and smoking cessation would be vital in risk reduction strategies.
P02-180 - Complicated Grief in Families of Enforced Disappearances
Authors: Hussain A. , Wani Z. , Rather Y. , Khan M. , Mushtaq H. 
Published: June 2010

ObjectiveTo determine incidence of complicated grief in the families of enforced disappearance in the conflict torn Kashmir valley. Complicated GRIEF is a recently identified symptom complex marked by continued separation distress and bereavement related accompanying traumatic distress.MethodsA total of 100 family members who were recruited from a workshop conducted by department of psychiatry and MEDICENS SAN FRONTIERS with family members of enforced disappearances were screened by psychiatrists.ResultsCOMPLICATED GREIF was very prevalent, 79% screened positive for complicated grief, PTSD was present in 30% of screened, 41% met criteria for major depressive disorder, 38% neither met criteria for major depressive disord: er nor PTSD, even though everybody who met criteria for PTSD had major depressive disorder as comorbidity.ConclusionCOMPLICATED GRIEF is a important diagnosis in this subgroup of population and results into significant distress and dysfunction and hence warrants attention.
P02-182 - Prevalence of Metabolic Syndrome in a UK Psychiatric Population
Authors: Millar H.L. 
Published: June 2010

ObjectivesSignificant physical co-morbidity is recognised as prevalent among patients with severe mental illness. UK guidelines for treatment of both schizophrenia (NICE 2009; Clinical guideline 82) and bipolar disorder (NICE 2006; Clinical guideline 38) provide recommendations for screening physical health problems. Despite the evidence base, physical health screening in this population is inconsistent. The Dundee Health Screen Clinic was set up to monitor cardiovascular and metabolic problems by providing health checks and offer exercise and dietary advice along with smoking cessation groups. This survey demonstrates the prevalence of metabolic syndrome in this sample, associated risk variables and prescribed antipsychotics.MethodMetabolic syndrome prevalence was assessed among 240 new patients attending the Dundee Health Screening clinic from Nov 2005-Aug 2008. The health screen designed included demographic details, clinical investigations, a lifestyle history and a record of prescribed medication.ResultsMetabolic syndrome (defined by the International Diabetes Federation (IDF) criteria) prevalence was 39.7%, with a higher propensity among those prescribed atypical versus typical antipsychotics. Predictors of metabolic syndrome suggested that BMI, a 10-year risk of CHD and diabetes are significantly associated with metabolic syndrome. 135 patients had dyslipidaemia with only 5.9% receiving lipid-lowering agents. Only 13 out of 94 patients with hypertension had received antihypertensive treatment.ConclusionsThis study identifies significant unmet medical need in the health screening of the severely mentally ill. Health screening programmes are required for this high risk population with early intervention and appropriate medical follow up to minimise cardiovascular risk and its associated morbidity and mortality.
P02-205 - Leigh Syndrome and Psychiatric Disorders
Authors: Mnif L. , Masmoudi J. , Baati I. , Damak R. , Halwani N. , Feki A. , Hadjkacem H. , Ayadi N. , Jaoua A. 
Published: June 2010

IntroductionEvidence is accumulating that mitochondrial dysfunction is involved in the pathophysiology of some psychiatric disorders such as Bipolar Disorder and Schizophrenia. In addition, among their other symptoms, people diagnosed with mitochondrial disease have high rates of psychiatric disorders. Leigh syndrome is a heterogeneous disorder, usually due to a defect in oxidative metabolism. The symptoms begin in the childhood by neurological troubles. Few reports mention psychiatric disorders. The objective of this work is to study relations between mitochondrial dysfunction and psychiatric disorders through a case of Leigh Syndrome.Case reportIt was a 20 year-old male patient, who had taken L-Dopa to treat severe extrapyramidal symptoms caused by Leigh syndrome. He developed, four months ago, acute psychotic symptoms such us audio-visual hallucinations, persecution and mystic delirium. The cerebral MRI had shown signal abnormalities in Basal Ganglia. This aspect was similar to those observed in the MRI having been practiced five years ago. The EEG recording was normal.The CSF and blood lactate levels were normal. The hypothesis that drug (L-Dopa) caused psychiatric disorders was possible. But, the digression of medicine was impossible due to the severity of extrapyramidal symptoms. The evolution under atypical antipsychotic was only partial.Discussion and conclusionIn this case, the CSF lactate levels mean that mitochondrial dysfunction is not an overall explanation for these psychiatric disorders but may at least play a partial role. Psychiatric disorders may be induced by drugs or may just be a simple comorbidity.
P02-208 - Compare of Bifrontal and Bitemporal Electroconvulsive Therapy (Side Effects and Hemodynamic Changes)
Authors: Nikfarjam M. , Najafi M. 
Published: June 2010

BackgroundECT is an effective and unknown treatment in the psychiatric patients. The authors compared the clinical and cognitive effects of bifrontal electrode placement with standard bitemporal electrode placement in the treatment of patient with major depression disorder and bipolar mood disorder.MethodTwenty -five patients with major depression disorder and Twenty-one patients with bipolar mood disorder were treated with a cource of bifrontal or bitemporal ECT. The Beck Rating Scale for depression and the Yung test for bipolar and the standardized Mini-Mental State Examination were adminestered at baseline and repeated during the cource of treatment (After 6th ECT& 1mouth later).ResultsForty-six of the 47 patients who completed the course of treatment met remission criteria by the 6th treatment. There were no differences between the patient given bifrontal ECT and those given bitemporal ECT in the number of treatment required to reach remission criteria. The standardized Mini-Mental State score of the patient given bitemporal ECT was simillar to those of the patient given bifrontal ECT. The result of Yung test and Beck test was similar in two BT&BF groups.ConclusionBifrontal electrode placement was as efficacious as bitemporal electrode placement and resulted the same cognitive impairment. A study of the two placements with more cognitine measures is indicated.
P02-210 - Verbal Fluency: Sex or Gender Characteristic
Authors: Nikolic-Balkoski G. , Duisin D. 
Published: June 2010

ObjectivesWho or what is responsible for sex caused differences in brain structure and functioning: our biological inheritance or is it simply the consequence and the result of learning, experience and socio cultural influence? Scientists with different approaches and different orientation agreed in one: responsibility for sex caused differences of cognitive capabilities share innate (genes and hormones) and acquired (experience and learning) factors.MethodologyStudies which consider cognitive abilities males and females are mostly done with heterosexual and homosexual individuals. The aim of this study was to asses some aspects of cognitive functioning of female-male transsexuals (FMT) and to compare it with the model of functioning of heterosexual female (HF) and male (HM) individuals.Experimental group consisted of seven FMT and 14 individuals were in HS group (seven in each, HM and HF). FMT were in stage of preparation for operative treatment, and transsexualism was diagnosed and guided within this program. We used Thurstone Test of Verbal Fluency as a written test for word fluency.Results and conclusionThe results showed that in the first part of the test (words starting with S) F-M transsexual group was the worst, and in the second part of the test (words with 4 letters starting with K) they had the score closer to homosexual females. Higher score in the last minutes in both parts of test had the group of F-M transsexuals and male heterosexuals. This could be interpreted as an outcome of better attention of individuals in these groups.
P02-218 - Case Report of Cerebellum Tuberculosis in 40 Years Old Male in Ardabil
Authors: Chini Froush M.M. , Rezaei Ghalechi E. 
Published: June 2010

BackgroundTuberculoma occurs in all age groups but are encountered most often during the first three decades of life. Recognized extra cranial infection or a history of exposure to tubercle bacilli are common but not constant feature.MethodMicroscopically, the process of caseation culminates centerally as a core of amorphous eosinophilic substance but remains imperfect peripherally as a basophilic band of karyorrhectic debris. It is in this outer zone that tubercle bacilli are to be found in greatest abundance. The firm lamina that surrounds the caseous component consists of chronically inflamed fibrous tissue, scattered islands of lymphoid cells, granulomas & giant cells. Polymorphonuclear leukocytes predominate in some lesion. The paucity of granulomatous inflammation in rare lesions produces a similarity to the more common pyogenic abscess. Granulomatous forms of cerebritis also are seen in other mycobacterial & fungal infections, parasitic or spirochetal infection, and in idiopathic condition such as sarcoidosis, crohn disease, SLE. The only way to establish a definitive diagnosis is by biopsy.ResultsSigns & symptoms as headache, seizures, papilledema, hemiplegia, and cerebellar dysfunction are expressions of the lesion's destructive & expansile nature. Fever may intimate its inflammatory character. In situ the Tuberculoma is remarkable for the contrast between its hard consistency & that of juxtaposed edematous brain.DiscussionAlthough, social & economic development lessen the incidence of brain tuberculomas, it might be a matter for the neurosurgeon which must be differentiated from abscess.
P02-221 - The “Gender Gap” in Authorship of Academic Psychiatric Literature
Authors: Sibitz I. , Amering M. , Schrank B. 
Published: June 2010

ObjectiveThe number of women in psychiatry has increased considerably during the past 40 years, but issues of concern persist regarding the advancement of women in academic medicine. The study explores the development of the representation of women among authors of scientific publications.MethodArticles published by three high impact general psychiatric journals - the Archives of General Psychiatry, the American Journal of Psychiatry and the British Journal of Psychiatry - were categorized according to characteristics of psychiatric research with respect to the researchers’ gender. Data were collected for the years 1994 and 2007.ResultsOverall the rate of female authors increased from about one fourth in 1994 to one third in 2007. The highest increases of female authors were found in the most relevant areas for academic career: first authorship, original research articles and publications on neuroimaging and genetics.ConclusionsDespite considerable gains, women still compose a minority of authors of scientific publications in the journals studied. Ongoing effort and interventions are required to promote further advances and gender equity.
P02-225 - Minimal invasive microneurosurgery technique for the treatment psychiatric diseases
Authors: Svadovsky A. 
Published: June 2010

IntroductionInvestigations of Cerebral Blood Flow (CBF) by Single Photon Emission Tomography (SPECT) revealed hypoperfusion/ischemia in different parts of the brain in psychiatric diseases.ObjectiveWe analysed 8 patients with psychiatric illness, such as autism (3), depression with psychosis (1), obsessive-compulsive disorder (2), Parkinson Disease with hallucinatory syndrome (1), Cerebral Palsy with autistic syndrome (1) which were investigated and underwent neurosurgery.7 patients were men, 1-woman.Age 3-34 years.Patients earlier got modern drugs therapy without success.AimsTo open a new physiological way of treatment of psychiatric illnesses.MethodsCT/MRI, EEG were performed in each case. We havent possibilities investigate by SPECT. Studies of CBF performed by Transcranial Doppler Ultrasound (TCD) on Middle Cerebral Artery in both side. TCD included blood flow velocity (BFV)/Gosling Pulse Index (PIG). We are create new minimal invasive neurosurgery for revascularization of the brain in patients with psychiatric illness. Ligation of 2-4 branches of external carotid arteries are executed by all patients that had provided redirection/reinforcement of arterial blood flow into internal carotid artery pool. Local or minimal general anesthesia used. Patent of RF, currently abroad.ResultsIn pre surgery in all patients BFV values were very low in compare with normal. PIG data always less on 30-55% to references. We accepted this trend as brain ischemia. After surgery positive correlation of TCD data and better psychiatric status was noted. Catamnesis tracked from 5 month till 5 years. No lethal cases and complications.ConclusionsWe considered that SPECT phenomenon of hypoperfusion and TCD signs of brain ischemia can play the essential role in pathogenesis of psychiatric diseases. Our surgery method is relatively simple and need not even in small trepanation and seriously anesthesiology provision.
P02-230 - “Psychogenic” Polidipsia and its Biological Correlates: a Case Report
Authors: Tournikioti K. , Gournellis R. , Voumvourakis K. , Moussas G. , Stamboulis E. , Lykouras L. 
Published: June 2010

ObjectivePrimary polydipsia is a clinical disorder characterized by excessive fluid intake (polydipsia) and consequent excessive fluid excretion (polyuria). The underlying pathophysiology of Primary polydipsia is still unclear. We present a case of a 26 year-old man without any previous psychiatric or neurological history who was thoroughly investigated for severe symptoms of polydipsia and polyuria. The only finding consisted of a probable micro-adenoma on the left side of the sella turcica.MethodsThe patient was thoroughly assessed by psychiatrists and psychologists through clinical and diagnostic interviews and was administered a wide range of psychometric tools including MMPI-2, SCID, YBOCS, BDI, HAM-17 and SCL-90. Moreover, he underwent a comprehensive physical and neurological examination, blood tests, renal function tests, endocrinological assessment including hormone assays, water deprivation test and desmopressin trial and brain Magnetic Resonance Imaging (MRI).ResultsNo major psychiatric disorder was detected apart from the presence of mild depressive symptoms. A brain MRI revealed a 4-5 mm diameter lesion on the left side of the sella turcica with lower contrast enhancement than the rest of the gland, which was suggestive of pituitary micro-adenoma.ConclusionWe considered the patient's depressive symptomatology as secondary to his condition. There is no other report of pituitary microadenoma in patients with symptoms of polydipsia and polyuria. We hypothesize that the location of the lesion may be related to the hypothalamic centre of thirst.