bluuebunny/crossref_metadata_2025_split huggingface dataset:
ChemInform Abstract: A Mild High‐Yielding Synthesis of Oxazole‐4‐carboxylate Derivatives.
Authors: Ferreira Paula M. T. , Castanheira Elisabete M. S. , Monteiro Luis S. , Pereira Goreti , Vilaca Helena 
Published: January 2011

AbstractOn treatment with DBU, esters of N‐acyl‐β‐halodehydraminobutyric acids produce the title compounds in good to excellent yields.
ChemInform Abstract: A Versatile Iron‐Catalyzed Protocol for the One‐Pot Synthesis of Isoxazoles or Isoxazolines from the Same Propargylic Alcohols.
Authors: Debleds Olivier , Gayon Eric , Ostaszuk Emilie , Vrancken Emmanuel , Campagne Jean‐Marc 
Published: January 2011

AbstractSimple tuning of the cyclization conditions allows for the practical one‐pot preparation of the bisubstituted isoxazoles (II), (IV) and N‐phenylsulfonyl‐2,3‐dihydroisozazoles (VI), (VII).
ChemInform Abstract: Molecular Iodine in [bmim][BF4]: A Highly Efficient Green Catalytic System for One‐Pot Synthesis of 1,3‐Oxathiolan‐5‐one.
Authors: Dewan Manika , Kumar Ajeet , Saxena Amit , De Arnab , Mozumdar Subho 
Published: January 2011

AbstractCompared to conventional solvents, [bmim]BF4 significantly accelerates the reaction of acid (I) with aromatic aldehydes.
ChemInform Abstract: Enantioselective Synthesis of the Novel Chiral Sulfoxide Derivative as a Glycogen Synthase Kinase 3β Inhibitor.
Authors: Saitoh Morihisa , Kunitomo Jun , Kimura Eiji , Yamano Toru , Itoh Fumio , Kori Masakuni 
Published: January 2011

AbstractA gram scale access to the novel GSK‐3β inhibitor (II) is presented using Kagan′s enantioselective oxidation procedure.
ChemInform Abstract: N‐Heterocyclic Carbene‐Catalyzed Reaction of Alkynyl Aldehydes with 1,3‐Keto Esters or 1,3‐Diketones.
Authors: Zhu Zhi‐Qiang , Xiao Ji‐Chang 
Published: January 2011

AbstractThe optimized method can be performed atom‐economically under mild conditions to afford highly functionalized 3,4‐dihydropyranones.
ChemInform Abstract: Palladium‐Catalyzed Tandem Heck‐Lactonization from o‐Iodophenols and Enoates: Synthesis of Coumarins and the Study of the Mechanism by Electrospray Ionization Mass Spectrometry.
Authors: Fernandes Talita de A. , Vaz Boniek Gontijo , Eberlin Marcos N. , da Silva Alcides J. M. , Costa Paulo R. R. 
Published: January 2011

AbstractIt is found that the title reaction is sensitive to steric hindrance around the enone double bond and proceeds via formation of cationic palladium intermediates.
ChemInform Abstract: Fluorous Diastereomeric Mixture Synthesis (FDMS) of Hydantoin‐Fused Hexahydrochromeno[4,3‐b]pyrroles.
Authors: Lu Yimin , Geib Steven J. , Damodaran Krishnan , Sui Bin , Zhang Zijuan , Curran Dennis P. , Zhang Wei 
Published: January 2011

AbstractEight possible diastereomers of hydantoin‐fused hexahydrochromenopyrrole (VI) are synthesized by FDMS.
ChemInform Abstract: A New Commercially Viable Synthetic Route for Donepezil Hydrochloride: anti‐Alzheimer′s Drug.
Authors: Dubey Shailendra Kumar , Kharbanda Manita , Dubey Sushil Kumar , Mathela Chandra Shekhar 
Published: January 2011

AbstractA new and economical approach to the anti‐Alzheimer′s drug donepezil (VI) is described.
ChemInform Abstract: Domino Imino‐Aldol—Aza‐Michael Reaction: One‐Pot Diastereo‐ and Enantioselective Synthesis of Piperidines.
Authors: Ghorai Manas K. , Halder Sandipan , Das Raj Kumar 
Published: January 2011

AbstractThe title reaction allows simple, general, and highly stereoselective access to highly functionalized target compounds.
ChemInform Abstract: Stereoselective Synthesis of 2,4,5‐Trisubstituted Piperidines via Radical Cyclization.
Authors: Ragoussi Maria‐Eleni , Walker Stephen M. , Piccanello Andrea , Kariuki Benson M. , Horton Peter N. , Spencer Neil , Snaith John S. 
Published: January 2011

AbstractIn the case of the silyl‐substituted educts (IX) and (XII), tandem 6‐exo‐trig and 5‐endo‐trig cyclizations are observed yielding the fused piperidines (XI).
ChemInform Abstract: Site‐Selective Cross‐Coupling of Dichlorinated Benzo‐Fused Nitrogen‐Heterocycles with Grignard Reagents.
Authors: Konishi Hideyuki , Itoh Tatsuya , Manabe Kei 
Published: January 2011

AbstractThe site‐selective cross‐coupling of dichlorinated benzo‐fused N‐heterocycles (I) having two chloro groups on the benzene ring is reported.
ChemInform Abstract: Rh‐Catalyzed Oxidative Coupling Between Primary and Secondary Benzamides and Alkynes: Synthesis of Polycyclic Amides.
Authors: Song Guoyong , Chen Dan , Pan Cheng‐Ling , Crabtree Robert H. , Li Xingwei 
Published: January 2011

AbstractThe reaction of secondary benzamides with alkynes allows a facile access to isoquinolones.
ChemInform Abstract: Perhydrofuro[3,2‐c]‐, Perhydropyrano[3,2‐c]‐ and 4‐Ethoxy‐2‐(5‐R‐furan‐2‐yl)tetrahydroquinolines. Synthesis and Transformations.
Authors: Zubkov F. I. , Zaitsev V. P. , Piskareva A. M. , Eliseeva M. N. , Nikitina E. V. , Mikhailova N. M. , Varlamov A. V. 
Published: January 2011

AbstractTitle furanyltetrahydroquinolines, e.g. (III) and (XII), are prepared by stereoselective cycloaddition of phenylimine (I) with either dihydrofuran, dihydropyran or vinyl ethyl ether (as previously described).
ChemInform Abstract: One‐Step Transformation of Tetracyanocyclopropyl Ketones into Pyrrolo[3,4‐c]pyridine Derivatives.
Authors: Kayukov Ya. S. , Bardasov I. N. , Kayukova O. V. , Ershov O. V. , Nasakin O. E. 
Published: January 2011

AbstractThe title reaction proceeds via recyclization of a furan‐ring intermediate into pyrrole and subsequent anellation of a pyridine ring.
ChemInform Abstract: Application of Cyclic 1,3‐Diketones in Domino and Multicomponent Reactions: Facile Route to Highly Functionalized Chromeno[2,3‐d]pyrimidinones and Diazabenzo[b]fluorenones under Solvent‐Free Conditions.
Authors: Kumar Ram , Raghuvanshi Keshav , Verma Rajiv K. , Singh Maya S. 
Published: January 2011

AbstractSimple procedures using InCl3 [cf.
ChemInform Abstract: A General and Practical Access to Chiral Quinoxalinones with Low Copper‐Catalyst Loading.
Authors: Tanimori Shinji , Kashiwagi Hiroaki , Nishimura Takeshi , Kirihata Mitsunori 
Published: January 2011

AbstractThe quinoxalinones are synthesized with high optical purity by a domino‐type reaction from 2‐bromoanilines and α‐amino acids in the presence of a diamine as ligand.
ChemInform Abstract: Diastereoselective Reduction of Chiral N‐Tosyl‐2‐benzoyl‐1,3‐oxazine Derived from (1R)‐(+)‐Camphor.
Authors: Ko Kwang‐Young , Yun Hoseop 
Published: January 2011

AbstractWith DIBAL‐H in ether the (S)‐alcohol of (IV) is formed with 81% e.e.
ChemInform Abstract: Reaction of 1,3‐Dimethyl‐3a,9a‐diphenyl‐3,3a,9,9a‐tetrahydroimidazo [4,5‐e]‐1,3‐thiazolo[3,2‐b]‐1,2,4‐triazine‐2,7(1H,6H)‐dione with Isatins.
Authors: Vasilevskii Sergei V. , Nelyubina Yulia V. , Kolotyrkina Natal'ya G. , Belyakov Pavel A. , Kulikova Lyudmila B. , Kravchenko Angelina N. 
Published: January 2011

AbstractSix compounds of type (III) are prepared by condensation reaction.
ChemInform Abstract: First Highly Enantioselective Synthesis of Benzodiazepinones by Catalytic Hydrogenation.
Authors: Rueping Magnus , Merino Estibaliz , Koenigs Rene M. 
Published: January 2011

AbstractThe microwave‐assisted method is based on the use of allyl Hantzsch ester AHE as hydride source and chiral N‐triflyl phosphoramide PHA as organocatalyst.
ChemInform Abstract: Regioselective Preparation of Functionalized exo‐Methylenecyclopentanes and exo‐Methylenepyrrolidines via Silaborative Carbocyclization of 1,6‐Enynes.
Authors: Gerdin Martin , Nadakudity Kumar , Worch Christin , Moberg Christina 
Published: January 2011

AbstractThe title reactions are performed with silylpinacolboranes (II) or (VII) by use of an catalytically active Pd(0) carbene species generated in situ by treatment of Pd(II) complex PIP with MeMgCl.
ChemInform Abstract: N‐Phosphorylated Imidazolium Salts as Precursors to 2‐ and 5‐Phosphorylated Imidazoles and New Imidazol‐2‐ylidenes Featuring the PNCN Unit.
Authors: Marchenko Anatolii P. , Koidan Heorgii N. , Huryeva Anastasiya N. , Zarudnitskii Evgeniy V. , Yurchenko Aleksandr A. , Kostyuk Aleksandr N. 
Published: January 2011

AbstractThe imidazolium salts are precursors of stable imidazol‐2‐ylidenes which upon heating undergo transformation into 2‐phosphorylated imidazoles.
ChemInform Abstract: CuS/Fe: A Novel and Highly Efficient Catalyst System for Coupling Reaction of Aryl Halides with Diaryl Diselenides.
Authors: Li Yaming , Wang Huifeng , Li Xiaoying , Chen Tao , Zhao Defeng 
Published: January 2011

AbstractThe coupling proceeds best with aryl iodides and is selective in the presence of other halides [cf.
ChemInform Abstract: Synthesis, Cytotoxicity and Antimalarial Activity of Ferrocenyl Amides of 4‐Aminoquinolines.
Authors: N'Da David D. , Breytenbach Jaco C. , Smith Peter J. , Lategan Carmen 
Published: January 2011

AbstractA series of ferrocenyl derivatives of type (V) are evaluated for their antimalarial activities against both chloroquine‐sensitive and resistant strains of Plasmodium falciparum.
ChemInform Abstract: Four New Cembrane Diterpenes Isolated from an Okinawan Soft Coral Lobophytum crassum with Inhibitory Effects on Nitric Oxide Production.
Authors: Wanzola Mpanzu , Furuta Takaaki , Kohno Yasuhisa , Fukumitsu Shunichi , Yasukochi Shuhei , Watari Kosuke , Tanaka Chiaki , Higuchi Ryuichi , Miyamoto Tomofumi 
Published: January 2011

AbstractIsolation and structure elucidation of title compounds (I)—(IV) are described.
ChemInform Abstract: Rhodamine—Sugar Based Turn‐On Fluorescent Probe for the Detection of Cysteine and Homocysteine in Water.
Authors: Yang Young‐Keun , Shim Soyoung , Tae Jinsung 
Published: January 2011

AbstractA complex of Au+ and rhodamine hydroxylamine (I) can selectively detect cysteine and homocysteine in aqueous solution in concentrations down to 100nM.
ChemInform Abstract: Synthesis and Hydrolysis of Bicyclic 2‐Imino‐2,5‐dihydrofurans Fused to a Pyridine Ring.
Authors: Avetisyan A. A. , Karapetyan L. V. , Tadevosyan M. D. 
Published: January 2011

AbstractThe diones (IV) may be regarded as analogues of the natural alkaloid cerpegin.
ChemInform Abstract: Synthesis and Antiviral Evaluation of 1′‐Branched‐5′‐norcarbocyclic Adenosine Phosphonic Acid Analogues.
Authors: Oh Chang Hyun , Yoo Kyung Ho , Hong Joon Hee 
Published: January 2011

AbstractNucleoside phosphonate (VII) and its derived phosphonic acid are subjected to antiviral screening against HSV, coxsakie B virus, poliovirus, and HIV.
ChemInform Abstract: Synthesis of SATE Prodrug of 6′‐Fluoro‐6′‐methyl‐5′‐noradenosine Nucleoside Phosphonic Acid as a New Class of anti‐HIV Agent.
Authors: Li Hua , Yoo Jin Cheol , Baik Young Chan , Lee Wonjae , Hong Joon Hee 
Published: January 2011

AbstractApplying the bis(SATE) approach leads to a novel SATE prodrug type (XI).
ChemInform Abstract: Concise Synthesis of (.+‐.)‐Perrottetinene with Bibenzyl Cannabinoid.
Authors: Park Byung Ho , Lee Yong Rok 
Published: January 2011

AbstractThe title compound (.+‐.)‐(VI) is structurally related to cannabinoids and is synthesized via hetero Diels—Alder reaction of a quinine methide intermediate, derived from citral addition product (III).
ChemInform Abstract: An Enantio‐ and Diastereocontrolled Synthesis of (‐)‐Salinosporamide A (X).
Authors: Sato Yosuke , Fukuda Hayato , Tomizawa Masaki , Masaki Tomohito , Shibuya Masatoshi , Kanoh Naoki , Iwabuchi Yoshiharu 
Published: January 2011

Abstractinvolving an organocatalytic aldolization, a Rh‐catalyzed Reformatsky reaction and an AZADO‐catalyzed oxidative β‐lactonization as key steps
ChemInform Abstract: Structural Modification of a Specific Antimicrobial Lead Against Helicobacter pylori Discovered from Traditional Chinese Medicine and a Structure—Activity Relationship Study.
Authors: Zhang Bang‐Le , Fan Cheng‐Qi , Dong Lei , Wang Fang‐Dao , Yue Jian‐Min 
Published: January 2011

AbstractA series of analogues of psoralen (Ia) is synthesized to improve the antimicrobial potency.
ChemInform Abstract: Synthesis of Magic‐Sized CdSe and CdTe Nanocrystals with Diisooctylphosphinic Acid.
Authors: Dukes Albert D. III , McBride James R. , Rosenthal Sandra J. 
Published: January 2011

AbstractMagic‐sized CdSe nanocrystals with band edge absorption peaks at 414, 446, and 490 nm, and magic‐sized CdTe nanocrystals with band edge absorption peaks at 445 and 483 nm are synthesized from CdO in hexadecylamine and Se or Te in PBu3 using diisooctylphosphonic acid as the capping ligand.
ChemInform Abstract: Design, Synthesis and Biological Evaluation of 3‐(4‐Halophenyl)‐3‐oxopropanal and Their Derivatives as Novel Antibacterial Agents.
Authors: Liu Jinbing , Yi Wei , Hu Jianming , Wu Fengyan , Zhao Liangzhong , Song Huacan , Wang Zhihou 
Published: January 2011

AbstractTitle compounds (I) and their precursors are tested for antimicrobial activity against both Gram‐positive and Gram‐negative bacteria.
ChemInform Abstract: Synthesis and Anticonvulsant Activity of Certain Substituted Furochromone, Benzofuran and Flavone Derivatives.
Authors: Ragab Fatma Abdel‐Fattah , El‐Sayed Nehad Aboul Magd , Eissa Amal Abdel Haleem Mohamed , El Kerdawy Ahmed Mahmoud 
Published: January 2011

AbstractAll newly synthesized benzofurans (I), furochromones (II), and flavones (III) as well as selected intermediates are evaluated for their anticonvulsant activity using both scPTZ and MES tests.
ChemInform Abstract: Design, Synthesis and Evaluation of Difunctionalized 4‐Hydroxybenzaldehyde Derivatives as Novel Cholinesterase Inhibitors.
Authors: Yu Liang , Cao Rihui , Yi Wei , Yan Qin , Chen Zhiyong , Ma Lin , Song Huacan 
Published: January 2011

AbstractA series of difunctionalized 4‐hydroxybenzaldehyde derivatives (I) is designed, synthesized, and evaluated as cholinesterase (AChE, BChE) inhibitors.
Crystal structure and phase transition of single crystalline CsNH2SO3
Authors: Fukami T. , Kyan T. , Nakano K. , Chen R. H. 
Published: January 2011

AbstractDifferential scanning calorimetry (DSC) and X‐ray diffraction measurements have been performed on cesium sulfamate CsNH2SO3 single crystal. Two distinct endothermic peaks in the DSC curves are observed at 330 and 436 K. It is pointed out that the peak at 330 K is attributed to the structural phase transition, and the other peak at 436 K is associated with the thermal decomposition of the crystal. The structures in room‐ and high‐temperasture phases are determined, and the space group of the sample crystal is found to change from monoclinic P 21/c to orthorhombic Pnma. The structure of the room‐temperature phase consists of two different types of N‐H···O hydrogen bond, but in the high‐temperature phase there is no specific hydrogen bond between the NSO3 pseudo‐tetrahera. (© 2011 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Hydrogen release in annealed hydrogenated a‐Si/a‐Ge multilayers
Authors: Frigeri C. , Serényi M. , Khánh N. Q. , Csik A. , Erdélyi Z. , Nasi L. , Beke D. L. , Boyen H.‐G. 
Published: January 2011

AbstractA combined study of hydrogenated sputtered single a‐Si and a‐Ge layers and a‐Si/a‐Ge multilayers (MLs) has been carried out in order to establish the reasons of H release and associated structural degradation of the MLs when they are submitted to annealing. ERDA analysis of the single layers of a‐Si and a‐Ge shows that H escapes from the layer much more efficiently in a‐Ge than in a‐Si. This agrees with IR absorbance measurements on the MLs showing that the Ge‐H signal disappears at a lower annealing time (for a given annealing temperature) than Si‐H and Si‐H2 do. The conclusion is drawn that the structural degradation of a‐Si/a‐Ge MLs primary starts with release of H in the Ge layers most probably because of the smaller binding energy of the H‐Ge bond and the greater weakness of the Ge lattice. (© 2011 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Efficient Acid–Base Bifunctional Catalysts for the Fixation of CO2 with Epoxides under Metal‐ and Solvent‐Free Conditions
Authors: Sun Jian , Han Lijun , Cheng Weiguo , Wang Jinquan , Zhang Xiangping , Zhang Suojiang 
Published: January 2011

AbstractA series of acid–base bifunctional catalysts (ABBCs) that contain one or two Brønsted acidic sites in the cationic part and a Lewis‐basic site in the anionic part are used as efficient catalysts for the synthesis of cyclic carbonates by cycloaddition of CO2 to epoxides, without the use of additional co‐catalyst or co‐solvent. The effects of the catalyst structures and various reaction parameters on the catalytic performance are investigated in detail. Almost complete conversion can be achieved in 1 h for propylene oxide using [{(CH2)3COOH}2im]Br under mild reaction conditions (398 K and 2 MPa). Furthermore, the catalyst can be recycled over five times without substantial loss of catalytic activity. This protocol is found to be applicable to a variety of terminal epoxides, producing the corresponding cyclic carbonates in good yields and high selectivities. A synergistic effect of the acidic and the basic sites as well as suitable hydrogen‐bonding strength of ABBCs are considered crucial for the reaction to proceed smoothly. The activities of the ABBCs increase remarkably with increasing carboxylic‐acid chain length of the cation. This metal‐ and solvent‐free process thus represents an environmentally friendly process for BTC‐catalyzed conversion of CO2 into value‐added chemicals.
Overall Water Splitting under Visible Light through a Two‐Step Photoexcitation between TaON and WO3 in the Presence of an Iodate–Iodide Shuttle Redox Mediator
Authors: Abe Ryu , Higashi Masanobu , Domen Kazunari 
Published: January 2011

AbstractA two‐step, photocatalytic water splitting system consisting of Pt‐loaded TaON (a H2 evolution photocatalyst), Pt‐loaded WO3 (an O2 evolution photocatalyst), and an iodate–iodide (IO3−/I−) shuttle redox mediator is investigated under visible light irradiation. Photocatalytic oxidation of water to O2 and reduction of IO3− to I− proceeded with good selectivity over the Pt–WO3 photocatalyst, even in the presence of a considerable amount of I− anions in the solution. The key difference between the adsorption properties of IO3− and I− anions on WO3 strongly suggested that the photoexcited electrons could react efficiently with IO3− adsorbed on WO3, whereas the photogenerated holes selectively reacted with water molecules owing to the low adsorptivity of I− on WO3. Photocatalytic H2 evolution on Pt–TaON proceeded efficiently, accompanied by I− oxidation to IO3− due to a substantial amount of adsorption of I− anions on the surface, whereas H2 evolution was significantly inhibited by the competitive adsorption of IO3−, which consumes photoexcited electrons. It was also found that WO3 photocatalysts loaded with platinum oxide (PtO) showed a much higher activity for O2 evolution in the presence of the electron acceptor IO3−, compared to those loaded with Pt metal. Overall water splitting at a steady rate was demonstrated using a combination of Pt–TaON and Pt(PtO)–WO3 in an aqueous NaI solution with neutral or weakly acidic pH values, where the concentration of NaI significantly affected the efficiency.
Hydrothermal Decarboxylation and Hydrogenation of Fatty Acids over Pt/C
Authors: Fu Jie , Lu Xiuyang , Savage Phillip E. 
Published: January 2011

AbstractWe report herein on the conversion of saturated and unsaturated fatty acids to alkanes over Pt/C in high‐temperature water. The reactions were done with no added H2. The saturated fatty acids (stearic, palmitic, and lauric acid) gave the corresponding decarboxylation products (n‐alkanes) with greater than 90 % selectivity, and the formation rates were independent of the fatty acid carbon number. The unsaturated fatty acids (oleic and linoleic acid) exhibited low selectivities to the decarboxylation product. Rather, the main pathway was hydrogenation to from stearic acid, the corresponding saturated fatty acid. This compound then underwent decarboxylation to form heptadecane. On the basis of these results, it appears that this reaction system promotes in situ H2 formation. This hydrothermal decarboxylation route represents a new path for using renewable resources to make molecules with value as liquid transportation fuels.
Joint rate regulation and power control for cochannel interference limited wireless networks
Authors: Wang Jui Teng 
Published: January 2011

AbstractCentralized and distributed algorithms for joint rate regulation and power control are proposed for the wireless networks where the cochannel interference limits the capacity. The goal of the proposed algorithms is maximizing the data rate while minimizing the transmitting power on each hop of the wireless networks. The distributed algorithm simulates the operation of the centralized algorithm in a distributed fashion and need not measure the link gains for all transmission links and interference links. We prove that the distributed algorithm can find the maximal transmitting rate and the minimal transmitting power as the centralized algorithm does. Simulation results also show that the proposed distributed algorithm outperforms the previous distributed algorithm in the data rate achieved. Copyright © 2011 John Wiley & Sons, Ltd.
On the design of algorithms for mobile multimedia systems: A survey
Authors: Ma Xiaoqiang , Liu Jiangchuan , Jiang Hongbo 
Published: January 2011

SUMMARYIn the past few years, we have seen a global flurry of the Internet in the rapid roll‐out of multimedia—the commercial products such as PPlive, YouTube, and Skype have occupied a large portion of Internet bandwidth. One reason behind the continual growth of multimedia services is due to the increasingly deployed and offered broadband networks. Besides the traditional wired end users, Internet service providers (ISPs) are expected to provide multimedia services, especially video streaming, to wireless end users as well in that it allows ISPs to strengthen their competitiveness by offering these new services. However, the existing solutions to multimedia in wired networks cannot directly apply to wireless networks with lower bandwidth, higher latency, and higher burst error rate. Furthermore, these services could suffer from user's mobility and the heterogeneity caused by different wireless technologies (e.g. CDMA2000, WCDMA, TD‐SCDMA, Wi‐Fi, Long‐Term Evolution (LTE), and WiMAX). This paper surveys several key issues of mobile multimedia, focusing on multirate multicast, scalable video coding (SVC), and QoS management. Besides, the opportunities as well as the challenges of providing multimedia services in the next generation wireless mobile systems—3GPP LTE—are investigated. Copyright © 2011 John Wiley & Sons, Ltd.
Mother–pup interactions during a short olfactory deprivation period in young rats
Authors: Gelhaye Mathieu , Padzys Guy Stéphane , Olry Jean‐Charles , Thornton Simon N. , Martrette Jean‐Marc , Trabalon Marie 
Published: January 2011

AbstractThe effects of short‐term bilateral naris occlusion (inducing olfactory deprivation) on mother–pup interactions, suckling behavior and hormonal status during post‐natal development in Wistar rats were studied. Bilateral naris occlusion was performed on 8‐day‐old rat pups and its effects were evaluated at Day 9 and at Day 15. The narins opened spontaneously between Day 12 and 14. Olfactory‐deprived pups exhibited a greater level of corticosterone at both ages versus untreated or sham animals. Olfactory deprivation via naris occlusion, in young rats, alters mother–pup interactions with a decrease in the duration of mother–pup retrieving and an increase in pup licking. Olfactory‐deprived pups showed also a lower mean duration of nursing and a decrease in nipple attachment, which appeared related to difficulties in finding the nipple. Olfactory‐deprived pups had difficulty recognizing their nest. These behavioral alterations were accompanied by a diminution in milk ingested and growth retardation associated with a reduced level of thyroxin at both 9 and 15 days of age. © 2011 Wiley Periodicals, Inc. Dev Psychobiol 53:303–316, 2011.