bluuebunny/crossref_metadata_2025_split huggingface dataset:
Catecholamine treatment induces reversible heart injury and cardiomyocyte gene expression
Authors: Bode Christine , Preissl Sebastian , Hein Lutz , Lother Achim 
Published: May 2024

Abstract
Background
Catecholamines are commonly used as therapeutic drugs in intensive care medicine to maintain sufficient organ perfusion during shock. However, excessive or sustained adrenergic activation drives detrimental cardiac remodeling and may lead to heart failure. Whether catecholamine treatment in absence of heart failure causes persistent cardiac injury, is uncertain. In this experimental study, we assessed the course of cardiac remodeling and recovery during and after prolonged catecholamine treatment and investigated the molecular mechanisms involved.

Results
C57BL/6N wild-type mice were assigned to 14 days catecholamine treatment with isoprenaline and phenylephrine (IsoPE), treatment with IsoPE and subsequent recovery, or healthy control groups. IsoPE improved left ventricular contractility but caused substantial cardiac fibrosis and hypertrophy. However, after discontinuation of catecholamine treatment, these alterations were largely reversible. To uncover the molecular mechanisms involved, we performed RNA sequencing from isolated cardiomyocyte nuclei. IsoPE treatment resulted in a transient upregulation of genes related to extracellular matrix formation and transforming growth factor signaling. While components of adrenergic receptor signaling were downregulated during catecholamine treatment, we observed an upregulation of endothelin-1 and its receptors in cardiomyocytes, indicating crosstalk between both signaling pathways. To follow this finding, we treated mice with endothelin-1. Compared to IsoPE, treatment with endothelin-1 induced minor but longer lasting changes in cardiomyocyte gene expression. DNA methylation-guided analysis of enhancer regions identified immediate early transcription factors such as AP-1 family members Jun and Fos as key drivers of pathological gene expression following catecholamine treatment.

Conclusions
The results from this study show that prolonged catecholamine exposure induces adverse cardiac remodeling and gene expression before the onset of left ventricular dysfunction which has implications for clinical practice. The observed changes depend on the type of stimulus and are largely reversible after discontinuation of catecholamine treatment. Crosstalk with endothelin signaling and the downstream transcription factors identified in this study provide new opportunities for more targeted therapeutic approaches that may help to separate desired from undesired effects of catecholamine treatment.
Multi-modal imaging for the detection of early keratoconus: a narrative review
Authors: Al Bdour Muawyah , Sabbagh Hashem M. , Jammal Hisham M. 
Published: May 2024

AbstractKeratoconus is a common progressive corneal disorder that can be associated with significant ocular morbidity. Various corneal imaging techniques have been used for the diagnosis of established cases. However, in the early stages of the disease, which include subclinical keratoconus and forme fruste keratoconus, detection of such cases can be challenging. The importance of detecting such cases is very important because early intervention can halt disease progression, improve visual outcomes and prevent postrefractive surgery ectasia associated with performing corneal refractive procedures in such patients. This narrative review aimed to examine several established and evolving imaging techniques for the detection of early cases of keratoconus. The utilization of combinations of these techniques may further increase their diagnostic ability.
Growth characteristics and classification systems of hemifacial microsomia: a literature review
Authors: Huh Joonyoung , Park Ji-Song , Sodnom-Ish Buyanbileg , Yang Hoon Joo 
Published: May 2024

Abstract
Background
Hemifacial microsomia is characterized by the hypoplasia of the mandible and temporomandibular joint, involving a variety of abnormalities of the craniofacial area. Since it gradually worsens as patients grow, it is necessary to understand the characteristics of facial bone growth and facial deformity in hemifacial microsomia patients in order to determine appropriate treatment timing and treatment methods.

Main body
Appropriate classification of hemifacial microsomia would facilitate accurate diagnosis, selection of treatment methods, and prognosis prediction. Therefore, in this article, we review previously published hemifacial microsomia classification and provide an overview of the growth of the facial skeleton and the characteristics of hemifacial microsomia-related facial deformities. The OMENS system is the most comprehensive classification method based on the characteristics of hemifacial microsomia deformity, but it needs to be improved to include malar/midface abnormalities and nerve involvement. In hemifacial microsomia, growth is progressing on the affected side, but to a lesser degree than the unaffected side. Therefore, surgical intervention in growing patients should be performed selectively according to the severity of deformity.

Conclusion
Understanding growth patterns is important to develop appropriate treatment protocols for correcting asymmetry in adult patients and to minimize secondary anomalies in growing patients.
Exploring carbon emission accounting methods for typical public institutions: a case study of hospitals
Authors: Zhang Lan , Zhang Rui , Ma Yuexin , Bai Yan 
Published: May 2024

AbstractTypical public institutions such as government offices, hospitals, and schools play important leading and exemplary roles in the green and low-carbon development of the whole society. This paper analyzes the business and energy consumption characteristics of public institutions, as well as the characteristics of personnel travel, and constructs a carbon accounting model for public institutions. It innovatively proposes a methodology for carbon accounting of personnel travel related to public institutions and validates and analyzes it using a comprehensive hospital as an example. The paper analyzes the carbon emission characteristics of various energy types, systems, and types of travelers in hospitals, provides schemes for the transformation of main energy systems, and corresponding emission reduction effects, thereby providing technical support for the full-chain carbon accounting of public institutions. Additionally, this paper explores the carbon reduction pathways for hospitals to support the peak carbon and carbon neutrality goals of public institutions, and promote the high-quality development of public institutions in China.
A Dose-Response Study on Functional and Transcriptomic Effects of FSH on Ex Vivo Mouse Folliculogenesis
Authors: Zhan Tingjie , Zhang Jiyang , Zhang Ying , Zhao Qingshi , Chemerinski Anat , Douglas Nataki C , Zhang Qiang , Xiao Shuo 
Published: May 2024

Abstract
Follicle-stimulating hormone (FSH) binds to its membrane receptor (FSHR) in granulosa cells to activate various signal transduction pathways and drive the gonadotropin-dependent phase of folliculogenesis. Both FSH insufficiency (due to genetic or nongenetic factors) and FSH excess (as encountered with ovarian stimulation in assisted reproductive technology [ART]) can cause poor female reproductive outcomes, but the underlying molecular mechanisms remain elusive. Herein, we conducted single-follicle and single-oocyte RNA sequencing analysis along with other approaches in an ex vivo mouse folliculogenesis and oogenesis system to investigate the effects of different concentrations of FSH on key follicular events. Our study revealed that a minimum FSH threshold is required for follicle maturation into the high estradiol-secreting preovulatory stage, and such threshold is moderately variable among individual follicles between 5 and 10 mIU/mL. FSH at 5, 10, 20, and 30 mIU/mL induced distinct expression patterns of follicle maturation–related genes, follicular transcriptomics, and follicular cAMP levels. RNA sequencing analysis identified FSH-stimulated activation of G proteins and downstream canonical and novel signaling pathways that may critically regulate follicle maturation, including the cAMP/PKA/CREB, PI3K/AKT/FOXO1, and glycolysis pathways. High FSH at 20 and 30 mIU/mL resulted in noncanonical FSH responses, including premature luteinization, high production of androgen and proinflammatory factors, and reduced expression of energy metabolism-related genes in oocytes. Together, this study improves our understanding of gonadotropin-dependent folliculogenesis and provides crucial insights into how high doses of FSH used in ART may impact follicular health, oocyte quality, pregnancy outcome, and systemic health.
Effects of antioxidant supplementation for polycystic ovary syndrome
Authors: Łopacińska Olga , Stańczyk Katarzyna , Korn Aleksandra , Czarnecka Karolina , Wójcik Emilia , Korczak Anna , Jędrzejczyk Justyna , Szewczyk Oliwia , Olek Ewa , Burda Katarzyna 
Published: May 2024

Introduction and purpose: Polycystic ovary syndrome is the most common endocrinopathy in women, with a prevalence ranging from 10% to 13%. Oxidative stress and decreased antioxidant levels contribute to the development of various diseases, and one of them is polycystic ovary syndrome. The aim of this review is to provide an overview of the current knowledge about the effects of antioxidant administration in PCOS treatment.
A brief description of the state of knowledge: Oxidative stress is an imbalance between increased levels of reactive oxygen species and a decreased efficiency of antioxidant mechanisms, which can potentially cause damage. The harmful effects of free radicals might be neutralized by antioxidants obtained from the diet, such as polyphenols, vitamins C, and E. These compounds improve several aspects of the PCOS pathomechanism, including hormonal imbalance, glucose metabolism, lipid profile, and ovarian functionality.
Conclusions: The outcomes of all the reviewed studies in this paper indicate that antioxidants such as resveratrol, curcumin, vitamin C and E, N-acetylcysteine, and melatonin have therapeutic potential in the management of PCOS. However, currently antioxidant therapies cannot be recommended in PCOS therapy since there is a need for more prospective randomized clinical trials on a larger sample to establish a long-term effects of antioxidants supplementation in PCOS, the optimal dosage, and finally to assess which antioxidant is the most efficient in PCOS treatment.
Measuring quality of life in older migrants: assessing the construct and convergent validity of the CASP-12 among older Chinese migrants
Authors: Szabó Ágnes , Sieng Vanessa , Du Amy , Allen Joanne , Yeung Polly 
Published: May 2024

Objectives:
Many people are ageing outside of their countries of origin, and the older adult population is becoming increasingly diverse globally. Although research with older migrants is growing, key constructs, such as quality of life (QOL), are routinely measured with instruments developed with the native population within a single country. Understanding the cultural appropriateness and validity of these measures should be a key focus for research with older migrants to ensure findings reported are based on reliable estimates. In this study, we investigated the validity of the CASP-12, an older adult-specific QOL scale, with a sample of older Chinese migrants in Aotearoa New Zealand.

Methods:
Survey data were collected from 245 older Chinese migrants. The CASP-12 and criterion measures assessing QOL, self-reported health, income adequacy, length of residence, perceived language barriers, household composition and education were administered.

Results:
Confirmatory factor analyses confirmed the three-factor structure of the CASP-12. Control & Autonomy, Pleasure and Self-realisation emerged as independent factors. A significant method effect was, however, identified in connection with reverse-scored items of the Control & Autonomy subscale, indicating a potential response bias. The CASP-12 and its subscales related to criterion measures in expected ways.

Conclusions:
There is partial evidence for the validity and reliability of the CASP-12 as a QOL measure to be used with older Chinese migrants. The presence of a method effect, however, suggests that estimates related to the Control & Autonomy subscale are impacted by bias, and revision of the CASP-12 may be necessary in the future.
Transport policies and their everyday impact on mobilities of older adults in Bengaluru
Authors: Nagesh Prajwal , Bailey Ajay , George Sobin , Ettema Dick , Subaiya Lekha 
Published: May 2024

Background and objectives:
Cities in the Global South are simultaneously witnessing wide-scale population ageing and rapid urbanisation. There is overwhelming pressure on policy makers to rapidly envision and provision age-friendly transport environments. In Indian cities, later-age mobilities face unique risks due to traffic congestion and inequities. However, the policy and transport research has treated congestion, equity and age-friendly mobilities as unrelated issues. This article goes a step ahead to understand how the policies to mitigate congestion can impact the provisioning of age-friendly infrastructure.

Research design and methods:
Bengaluru, once termed the ‘pensioners’ paradise’, is known for its ‘alarming’ levels of traffic congestion (Pucher et al, 2005; Pojani and Stead, 2017). We review Bengaluru’s transport policies and peer-reviewed articles concerning these policies to understand the positioning of age-friendly transport within this context.

Results:
Our findings recognise a shift from sufficientarianism to utilitarian orientations in Bengaluru’s policy making on easing congestion, which narrows the options for later-age transport users in terms of access and affordability. Some of the features not unique to Bengaluru – such as top-down planning, institutional fragmentation and distancing of users from policy making – have resulted in buses being inaccessible for passengers with mobility issues, metro rail being unaffordable for those on low incomes, lack of safe modes of transport and safe access to streets.

Discussion and implications:
The article is an initial foray into the ambiguity in the philosophical underpinning of transport policy making, which prioritises solving congestion ahead of providing age-friendly transport. We highlight specific challenges the cities of the Global South experience as they envision age-friendly transport policies amid the ascendance of congestion-solving policies.
Evaluation of the effect of testosterone replacement therapy with a transdermal testosterone on glycemic control in men with type 2 diabetes mellitus
Authors: Rozhivanov R. V. , Chernova M. O. , Ioutsi V. A. , Mel’nichenko G. A. , Shestakova M. V. , Rozhivanova E. R. , Andreeva E. N. , Mokrysheva N. G. 
Published: May 2024

BACKGROUND: It is important to evaluate the effect of androgen replacement therapy on glycemic control.AIMS: Assessment of the effect of transdermal testosterone therapy on glycemic control in men with hypogonadism and T2DM.MATERIALS AND METHODS: The prospective, comparative study included 300 men aged 55[49;61] years: men receiving both glucose-lowering therapy (GLT) and transdermal testosterone; and patients receiving only GLT. Observation period 1 year. A medical history, a questionnaire for symptoms of androgen deficiency, and measurement of total testosterone and glycated hemoglobin were carried out. Groups were compared using nonparametric methods.RESULTS: Patients receiving androgen replacement therapy in combination with GLT at both 6 and 12 months from the moment of inclusion in the study, they had a statistically significantly higher level of total testosterone and less severity of symptoms of androgen deficiency. When assessing the magnitude of changes in the studied parameters, it was found that patients receiving testosterone replacement therapy (TRT) were characterized by a statistically significantly more pronounced decrease in the level of glycated hemoglobin (average difference 0,3%). In 29 (20,4% (95% ДИ 13,8–27,0)) men who received only GLT, hypogonadism was eliminated. In 3 patients from the TRT group, a pathological increase in the level of total blood PSA was observed, and therefore TRT was discontinued. An increase in hemoglobin above the reference value (>172 g/l) was detected in 8% and 1,3% of men on TRT and without correction of hypogonadism, respectively, p=0,011.CONCLUSIONS: The combination of transdermal TRT and GLT has a positive effect on glycemic control, which is manifested by a decrease in glycated hemoglobin to a greater extent than when using GLT alone. Normalization of testosterone levels leads to a decrease in the symptoms of androgen deficiency, which is accompanied by an improvement in quality of life. Elimination of hypogonadism only with GLT is possible in a small number of cases.
Связь субъективной религиозности с антииммигрантскими установками в Европе: анализ на основе данных Европейского социального исследования (ESS)
Authors: Парвадов Семен Олегович 
Published: May 2024

В работе рассматривается, как субъективная религиозность и конфессиональная принадлежность связаны с антииммигрантскими установками в европейских странах на индивидуальном уровне. Теоретической основой исследования выступают теория культурной угрозы и теория религиозного сострадания. Согласно теории культурной угрозы, религиозность и конфессиональная принадлежность могут маркировать идентичность и быть основанием для антииммигрантских установок в результате конструируемого страха размытия этнокультурного единства. Теория религиозного сострадания, напротив, подчеркивает, что религиозным индивидам свойственно разделять альтруистические ценности, а это предполагает эмпатичное отношение к иммигрантам как уязвимой группе.
Исходя из таких предположений, автор выдвигает гипотезы и тестирует их на данных десятой волны Европейского социального исследования (ESS) по 30 европейским странам (общий объем выборки N = 23 624). В качестве главных предикторов выбраны уровень субъективной религиозности и конфессиональная принадлежность респондента. В качестве зависимых переменных выступают ответы на два вопроса, раскрывающие готовность респондента принимать иммигрантов разного происхождения — той же этнической группы/расы или отличной от большинства. Основным методом анализа выступило регрессионное моделирование: были построены множественные линейные модели с робастными оценками.
В результате установлено, что статистические связи с антииммигрантскими установками имеет не только субъективная религиозность респондента, но и его принадлежность к определенной конфессии, а также эффекты их взаимодействия. Теория культурной угрозы продемонстрировала больший объяснительный потенциал, в то время как предположения, связанные с теорией религиозного сострадания, не нашли подтверждения.
Блогеры в сфере здоровья в оценках горожан: практики, коммуникация, доверие
Authors: Богомягкова Елена Сергеевна 
Published: May 2024

В статье представлены результаты комбинированного эмпирического исследования, реализованного в 2020―2021 гг. и включавшего полуструктурированные интервью с жителями крупных городов России (n = 90), а также телефонный опрос жителей Санкт-Петербурга (n = 861). Цель работы ― описать опыт обращения к материалам интернет-инфлюенсеров, специализирующихся на теме здоровья, и специфику коммуникации в их блогах, а также осветить механизмы формирования доверия новым экспертам. Показано, что обращение к материалам блогеров, работающих в сфере здоровья, — одновременно рутинная и ситуативная практика для горожан. Тематика запросов и «специализация» наиболее популярных блогеров демонстрируют, что больший интерес представляет информация не о методах лечения, а о способах поддержания хорошего самочувствия. Сетевой характер коммуникации в блогах, отличающий ее от институциональных форм, требует доверия, критериями формирования которого выступают контент, персонификация, сетевой капитал, публичность, соответствие рекомендаций личному опыту пользователя. Практики чтения постов и просмотра видео в большей степени свойственны молодым респондентам, наиболее интегрированным в интернет-коммуникации и доверяющим онлайн-источникам информации о здоровье. С большей вероятностью к блогерам прислушиваются горожане, усвоившие новые способы заботы о здоровье: внимание к эмоциональному состоянию, контроль питания, цифровой селф-трекинг. Доверие к интернет-инфлюенсерам невелико и не связано с (не)доверием врачам. Востребованность блогов о здоровье объясняется вниманием к вопросам здорового образа жизни и особенностями взаимодействия новых экспертов с пользователями. Блогеры занимают тематические ниши, где не присутствует официальное здравоохранение, при этом выступая не альтернативными, а параллельными институциональной медицине структурами, коммуникации в которых соответствуют трендам социальных изменений и привлекательны для горожан.
Благодарность. Материал подготовлен при финансовой поддержке РНФ в рамках научного проекта № 21-18-00125. Автор выражает благодарность М. Е. Глуховой (аспирантка ЕУСПб), А. А. Дупак (магистр социологии), А. С. Захаровой (магистр социологии) за помощь в сборе эмпирического материала.
Ultrasonic-assisted alkali hydrolysis of polyethylene terephthalate fabric and its effect on the microstructure and dyeing properties of fibers
Authors: Pan Sihui , Qian Hongfei 
Published: May 2024

Abstract
In this study, ultrasound energy was applied to assist the alkali hydrolysis of polyethylene terephthalate (PET) fabric, and then, the results were compared with those of the mechanical oscillating method, which was used as the control. The effects of various factors such as the sodium hydroxide concentration, the dosage of dodecyl dimethyl benzyl ammonium chloride (DDBAC), and the frequency on the weight loss of the PET fabrics were systematically investigated. The surface appearance and microstructures of the treated fibers with different methods were analyzed using a scanning electron microscope and X-ray diffraction, respectively. The results showed that DDBAC played a prominent accelerating role in the hydrolysis of the PET polymer, and the frequency had a great influence on the weight loss of the PET fabric. Ultrasound with a frequency of 60 kHz showed a similar decomposition rate as the control, resulting in similar weight loss, which was the highest value among the three frequencies (20, 60, and 80 kHz). In addition, the application of ultrasonic energy led to more pits on the fiber surface, a smaller average grain size, and decreased crystallinity of the treated fibers, while the mechanical oscillating method resulted in slightly increased crystallinity. By comparing the K/S value of the dyed fabrics with two commercial disperse dyes, we found that the treatment method had no obvious correlation with the color depth of the treated fabric.
Geometric invariants properties of osculating curves under conformal transformation in Euclidean space ℝ3
Authors: Singh Kuljeet , Sharma Sandeep , Lone Mohamd Saleem 
Published: May 2024

Abstract
An osculating curve is a type of curve in space that holds significance in the study of differential geometry. In this article, we investigate certain geometric invariants of osculating curves on smooth and regularly immersed surfaces under conformal transformations in Euclidean space

R

3

{{\mathbb{R}}}^{3}

. The primary objective of this article is to explore conditions sufficient for the conformal invariance of the osculating curve under both conformal transformations and isometries. We also compute the tangential and normal components of the osculating curves, demonstrating that they remain invariant under the isometry of the surfaces in

R

3

{{\mathbb{R}}}^{3}

.