bluuebunny/crossref_metadata_2025_split huggingface dataset:
ChemInform Abstract: Tartaric Acid‐Catalyzed Synthesis of α‐Aminophosphonates under Solvent‐Free Conditions.
Authors: Gangwar Nidhi , Kasana Virendra Kumar 
Published: July 2012

Abstract12 α‐Aminophosphonates of type (IV) are prepared in a one‐pot three‐component reaction using tartaric acid as catalyst, which provides easier work‐up, affords better yields and takes less reaction time in comparison to generally used Lewis acid catalysts.
ChemInform Abstract: Syntheses, Structure and Electrochemical Anion Recognition of 5‐Ferrocenylisophthalicdiacyl Hydrazones.
Authors: Li Xia , Liu Wei , Zheng Haijin , Zhao Jin'an , Song Maoping 
Published: July 2012

AbstractThe ferrocene derivatives (IV) possess potential application as sensors for H2PO‐4‐anions.
ChemInform Abstract: An Unexpected Elimination Reaction of 3,14,19‐Triacetylandrographolide.
Authors: Yang Yi , Lan Tian , Zhang Qianqian , Wang Jin‐Tao , Xu Li , Zhang Xi‐min , Geng Jian‐Guo , Wang Li‐jing 
Published: July 2012

AbstractAttempted Prevost hydroxylation of triacetylandrographolide (I) affords an unusual and unexpected ene‐product (III).
ChemInform Abstract: Syntheses of Structurally‐Simplified (VI)/(VII) and Fluorescently‐Labeled Neovibsanin Derivatives (VIII) and Analysis of Their Neurite Outgrowth Activity in PC12 Cells.
Authors: Imagawa Hiroshi , et al. et al. 
Published: July 2012

AbstractCompounds (VIa)/(VIIa) promote significantly the NGF‐mediated neurite outgrowth at the same level as that of natural (.+‐.)‐neovibsanin B.
ChemInform Abstract: Lipase‐Catalyzed Regioselective Acylation of Sugar in Microreactors.
Authors: Du Li‐Hua , Luo Xi‐Ping 
Published: July 2012

AbstractA highly regioselective synthesis of sugar 6‐monoesters, e.g. (III), is achieved using lipozyme (Thermomyces lanuginosus) immobilized on silica spheres in a continuous flow reactor.
ChemInform Abstract: Synthesis of 1,2,3‐Triazolylpyranosides Through Click Chemistry Reaction.
Authors: Stefani Helio A. , Silva Nathalia C. S. , Manarin Flavia , Luedtke Diogo S. , Zukerman‐Schpector Julio , Madureira Lucas Sousa , Tiekink Edward R. T. 
Published: July 2012

AbstractThe 1,3‐dipolar cycloaddition between protected C‐alkynyl‐glycosides and organic azides is promoted by CuI.
ChemInform Abstract: Regio‐ and Stereoselective C10β—H Functionalization of Sinomenine: An Access to More Potent Immunomodulating Derivatives.
Authors: Yang Zhen‐Yu , et al. et al. 
Published: July 2012

AbstractAll newly synthesized compounds are evaluated for their pro‐inflammatory cytokine tumor necrosis factor‐α (TNF‐α) for the mouse macrophage cell line J774.
ChemInform Abstract: Isolation and Identification of Antibacterial Neo‐Compounds from the Red Ants of ChangBai Mountain, Tetramorium sp.
Authors: Song Zheng‐Wei , Liu Pu , Yin Wei‐Ping , Jiang Ya‐Ling , Ren Yun‐lai 
Published: July 2012

AbstractThree new compounds (I) ‐ (III) show moderate effects against Gram‐positive Bacillus subtilis strain but no activity against Gram‐negative strains.
Goodness‐of‐fit testing based on a weighted bootstrap: A fast large‐sample alternative to the parametric bootstrap
Authors: Kojadinovic Ivan , Yan Jun 
Published: July 2012

AbstractThe process comparing the empirical cumulative distribution function of the sample with a parametric estimate of the cumulative distribution function is known as the empirical process with estimated parameters and has been extensively employed in the literature for goodness‐of‐fit testing. The simplest way to carry out such goodness‐of‐fit tests, especially in a multivariate setting, is to use a parametric bootstrap. Although very easy to implement, the parametric bootstrap can become very computationally expensive as the sample size, the number of parameters, or the dimension of the data increase. An alternative resampling technique based on a fast weighted bootstrap is proposed in this paper, and is studied both theoretically and empirically. The outcome of this work is a generic and computationally efficient multiplier goodness‐of‐fit procedure that can be used as a large‐sample alternative to the parametric bootstrap. In order to approximately determine how large the sample size needs to be for the parametric and weighted bootstraps to have roughly equivalent powers, extensive Monte Carlo experiments are carried out in dimension one, two and three, and for models containing up to nine parameters. The computational gains resulting from the use of the proposed multiplier goodness‐of‐fit procedure are illustrated on trivariate financial data. A by‐product of this work is a fast large‐sample goodness‐of‐fit procedure for the bivariate and trivariate t distribution whose degrees of freedom are fixed. The Canadian Journal of Statistics 40: 480–500; 2012 © 2012 Statistical Society of Canada
Statin and Aspirin Therapy for the Prevention of Cardiovascular Events in Patients With Type 2 Diabetes Mellitus
Authors: Udell Jacob A. , Scirica Benjamin M. , Braunwald Eugene , Raz Itamar , Gabriel Steg Ph. , Davidson Jaime , Hirshberg Boaz , Bhatt Deepak L. 
Published: July 2012

AbstractPatients with type 2 diabetes mellitus are at 2 to 4 times increased risk of cardiovascular events compared with those without diabetes, both among patients with multiple risk factors only and those with established atherothrombosis. In this review, we provide recommendations for the use of statins and aspirin for the prevention of cardiovascular events in high‐risk patients with diabetes mellitus. Clin. Cardiol. 2012 doi: 10.1002/clc.22032The SAVOR‐TIMI 53 trial is sponsored by AstraZeneca and Bristol‐Myers Squibb. Dr. Udell is a recipient of a Postdoctoral Research Fellowship from the Canadian Institutes for Health Research (CIHR) and Canadian Foundation for Women's Health. Dr. Scirica receives research grants from AstraZeneca, Bristol‐Myers Squibb, Merck, Johnson & Johnson, Bayer Healthcare, and Gilead Sciences and consultancy fees from Gilead Sciences, Lexicon, and Arena Pharmaceuticals. Dr. Braunwald receives research grants from AstraZeneca and Bristol‐Myers Squibb. Dr. Raz has received honoraria/expenses for advisory board participation from AstraZeneca, Bristol‐Myers Squibb, Novo Nordisk, Merck, Sharp & Dohme, and Eli Lilly; has served as a consultant for Andromea, AstraZeneca, Bristol‐Myers Squibb, Eli Lilly, Johnson & Johnson, HealOr, Insuline, Teva, and TransPharma; and has participated in speakers bureaus for AstraZeneca, Bristol‐Myers Squibb, Eli Lilly, Novo Nordisk, Johnson & Johnson, and Roche. Dr. Steg receives research grants from Servier. Dr. Davidson participated on advisory panels for AstraZeneca, Bristol‐Myers Squibb, Merck, Johnson & Johnson, Boehringer Ingelheim, Eli Lilly, Generex Biotechnology, Novo Nordisk A/S, Roche Diagnostics, and Takeda Pharmaceutical Company and participated in speaker's bureaus for Eli Lilly and Takeda Pharmaceutical Company. Dr. Hirshberg is an employee of and holds stock in AstraZeneca. Dr. Bhatt discloses the following relationships—Advisory Board: Medscape Cardiology; Board of Directors: Boston VA Research Institute, Society of Chest Pain Centers; Chair: American Heart Association Get With The Guidelines Science Subcommittee; Honoraria: American College of Cardiology (Editor, Clinical Trials, Cardiosource), Duke Clinical Research Institute (clinical trial steering committees), Slack Publications (Chief Medical Editor, Cardiology Today Intervention), WebMD (CME steering committees); Research Grants: Amarin, AstraZeneca, Bristol‐Myers Squibb, Eisai, Ethicon, Medtronic, Sanofi Aventis, The Medicines Company; Unfunded Research: FlowCo, PLx Pharma, Takeda. The design and conduct of the SAVOR‐TIMI 53 study are being done by the academic executive committee in collaboration with the sponsors.
Phase 2 trial of daily, oral polyphenon E in patients with asymptomatic, Rai stage 0 to II chronic lymphocytic leukemia
Authors: Shanafelt Tait D. , Call Timothy G. , Zent Clive S. , Leis Jose F. , LaPlant Betsy , Bowen Deborah A. , Roos Michelle , Laumann Kristina , Ghosh Asish K. , Lesnick Connie , Lee Mao‐Jung , Yang Chung S. , Jelinek Diane F. , Erlichman Charles , Kay Neil E. 
Published: July 2012

AbstractBACKGROUND:The objective of the current study was to follow up the results of phase 1 testing by evaluating the clinical efficacy of the green tea extract Polyphenon E for patients with early stage chronic lymphocytic leukemia (CLL).METHODS:Previously untreated patients with asymptomatic, Rai stage 0 to II CLL and an absolute lymphocyte count (ALC) ≥ 10 × 109/L were eligible for this phase 2 trial. Polyphenon E with a standardized dose of epigallocatechin gallate (EGCG) (2000 mg per dose) was administered twice daily.RESULTS:A total of 42 patients received Polyphenon E at a dose of 2000 mg twice daily for up to 6 months. Of these patients, 29 (69%) had Rai stage I to II disease. Patients received a median of 6 cycles of treatment (range, 1 cycle‐6 cycles). The most common grade 3 side effects (according to National Cancer Institute Common Terminology Criteria for Adverse Events) were transaminitis (1 patient), abdominal pain (1 patient), and fatigue (1 patient). Clinical activity was observed, with 13 patients (31%) experiencing a sustained reduction of ≥ 20% in the ALC and 20 of 29 patients (69%) with palpable adenopathy experiencing at least a 50% reduction in the sum of the products of all lymph node areas. EGCG plasma levels after 1 month of therapy were found to be correlated with reductions in lymphadenopathy (correlation co‐efficient, 0.44; P = .02). Overall, 29 patients (69%) fulfilled the criteria for a biologic response with either a sustained decline ≥ 20% in the ALC and/or a reduction ≥ 30% in the sum of the products of all lymph node areas at some point during the 6 months of active treatment.CONCLUSIONS:Daily oral EGCG in the Polyphenon E preparation was well tolerated by patients with CLL in this phase 2 trial. Durable declines in the ALC and/or lymphadenopathy were observed in the majority of patients. Cancer 2013. © 2012 American Cancer Society.
Dimerization Reaction of Regioisomeric Bis(phenylethynyl)benzene Radical Anions during Pulse Radiolysis
Authors: Fujitsuka Mamoru , Samori Shingo , Tojo Sachiko , Haley Michael M. , Majima Tetsuro 
Published: July 2012

AbstractDimerization of a series of regioisomeric 1,4‐, 1,3‐, and 1,2‐bis(phenylethynyl)benzene radical anions (bPEBs.−) substituted by various electron‐donor and/or electron‐acceptor groups was studied during the pulse radiolysis in N,N‐dimethylformamide (DMF). The transient absorption of bPEB.− decayed with the formation of new bands attributed to the dimer radical anion of bPEB.− and bPEB (bPEB2.−). From the dependence of decay and formation rates on the concentration of bPEB, the bimolecular rate constants of kb=(1.2±0.1)×107 to (3.2±0.2)×108 M−1 s−1 were estimated. It is suggested that bPEB.− dimerizes with bPEB through the formation of a CC bond between two sp carbon atoms, to give σ‐type dimer radical anion (σ‐(bPEB)2.−) with a diene‐type structure. The kb values of bPEB.− with bPEB changed with the substitution pattern of the phenylacetylene group on the central benzene ring and the various kinds of donor and/or acceptor group.
Structural and optoelectrical properties of Ga‐doped ZnO semiconductor thin films grown by magnetron sputtering
Authors: Zhou J. , Zhong Z. Y. 
Published: July 2012

AbstractTransparent conductive gallium‐doped zinc oxide (Ga‐doped ZnO) films were prepared on glass substrate by magnetron sputtering. The influence of substrate temperature on structural, optoelectrical and surface properties of the films were investigated by X‐ray diffraction (XRD), X‐ray photoelectron spectroscopy (XPS), spectrophotometer, four‐point probe and goniometry, respectively. Experimental results show that all the films are found to be oriented along the c‐axis. The grain size and optical transmittance of the films increase with increasing substrate temperature. The average transmittance in the visible wavelength range is above 83% for all the samples. It is observed that the optoelectrical property is correlated with the film structure. The Ga‐doped ZnO film grown at the substrate temperature of 400 °C has the highest figure of merit of 1.25 × 10−2 Ω−1, the lowest resistivity of 1.56 × 10−3 Ω·cm and the highest surface energy of 32.3 mJ/m2.
Morphological alteration of anatase titania nanostructures depend on the amount of Na ion intercalation
Authors: Ren Long , Qi Xiang , Liu Yundan , Zou Xianghua , Huang Zongyu , Li Jun , Yang Liwen , Zhong Jianxin 
Published: July 2012

AbstractControllable preparation of different nanoscale‐shaped titania materials was realized by hydrothermal treatment of anatase TiO2 in an alkaline solution. The gradually changing morphologies and microstructures of titanium dioxide were investigated by powder X‐ray diffraction, scanning electron microscopy and transmission electron microscopy. And a top‐down path is illuminated to have an insight to the morphological evolution from nanoparticle to nanosheet by adjusting the concentrations of Na ion in the aqueous solution. The results of photocatalytic experiments indicated that the TiO2 nanobelts exhibited enhanced photocatalytic performance, due to their lower electron‐hole recombination rate confirmed from the photoluminescence spectra. This study suggests that the photocatalysis efficiency of nanocrystals can be significantly improved by the shape‐dependent morphological transformation.
Aril development in Celastraceae
Authors: Zhang Xin , Zhang Zhixiang , Stützel Thomas 
Published: July 2012

AbstractTo learn more about the evolution of secondarily intercalated seed envelopes, a series of developmental studies of arillate seeds in gymnosperms and angiosperms was undertaken. The goal was to test whether the second (outer) integument could be derived from an aril of gymnospermous ancestors. In our developmental studies of three species of Celastraceae, however, it turned out that the structure termed aril in this family does not originate from the funiculus or the hilum but from the exostomatic micropyle. As a consequence, the micropyle is not inside the aril but at the base of the fleshy structure which is thus better referred to as a caruncula. The fleshy part in seeds of Celastraceae differs thus markedly from those seed appendages usually referred to as an aril. (© 2011 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Safety of quetiapine fumarate extended release in the treatment of Korean patients with acute schizophrenia
Authors: Lee Jung‐Goo , Lee Jong‐Il , Kim Yang‐Tae , Kim Chul‐Eung , Kim Chang‐Yoon , Yoon Jin‐Sang , Yoo So‐Young , Kim Young‐Hoon 
Published: July 2012

IntroductionThe aim of this study was to evaluate the efficacy and safety of quetiapine fumarate extended release (XR) in the treatment of Korean subjects with acute schizophrenia.MethodsThis was an 8‐week, multi‐center, open‐label, non‐comparative study to evaluate the efficacy and safety of quetiapine fumarate XR at a daily dose of 400–800 mg. Changes in total scores on the Positive and Negative Syndrome Scale (PANSS) from baseline to week 8 were analyzed to evaluate the efficacy of quetiapine XR. Additionally, the Clinical Global Impression scale and the Montgomery–Åsberg Depression Rating Scale were administered.ResultsThe mean change in PANSS total scores was −26.8, and the mean PANSS total score at the endpoint was significantly lower than that at baseline. The mean PANSS positive score, negative score, and general score showed statistically significant reductions at the end of the study. Statistically significant changes were also observed in Clinical Global Impression‐Severity and Montgomery–Åsberg Depression Rating Scale scores. The most common treatment‐related adverse events in the group receiving quetiapine XR were sedation (10.6%) and constipation (9.6%).ConclusionsIn this study of Korean patients with acute schizophrenia, quetiapine XR showed clinical efficacy and relatively good tolerability. Copyright © 2012 John Wiley & Sons, Ltd.
Ammonium occurrence in a salinized lowland coastal aquifer (Ferrara, Italy)
Authors: Mastrocicco M. , Giambastiani B.M.S. , Colombani N. 
Published: July 2012

AbstractTo understand the spatial distribution and the possible sources of high ammonium concentration in the unconfined coastal aquifer of the Po River Delta lowland (Italy), a detailed characterization of inorganic nitrogen species was completed. A total of 59 boreholes were drilled to collect core samples and groundwater samples of the aquifer. Among them, four piezometers, located along a representative flow line, were chosen to monitor the inorganic nitrogen concentrations with depth. Ammonium is the prevalent nitrogen inorganic species in groundwater, and its concentration increases with depth and salinity. Very high ammonium concentrations are found in coincidence with peaty sediments in the salinized anoxic aquifer and in the low‐lying aquitard. In particular, the elevated ammonium concentration derives from mineralization of organic matter present in fine sediments deposited in paleo‐marsh environments. Copyright © 2012 John Wiley & Sons, Ltd.
Diclofenac inhibits lactate formation and efficiently counteracts local immune suppression in a murine glioma model
Authors: Chirasani Sridhar R. , Leukel Petra , Gottfried Eva , Hochrein Jochen , Stadler Katrin , Neumann Bernhard , Oefner Peter J. , Gronwald Wolfram , Bogdahn Ulrich , Hau Peter , Kreutz Marina , Grauer Oliver M. 
Published: July 2012

AbstractLactate formation in highly proliferative tumors such as malignant gliomas is associated with poor survival and contributes to the suppression of local immunity. Here, we report that diclofenac used at nontoxic concentrations significantly decreased lactate production in murine glioma cells and inhibited the expression of lactate dehydrogenase‐A in vitro. Lactate reduction was accompanied by a dose‐dependent inhibition of cell growth and a cell cycle arrest at the G2/M checkpoint. In the presence of diclofenac, murine bone marrow‐derived dendritic cells (DCs) showed enhanced IL‐12, but decreased IL‐10 secretion on Toll‐like receptor stimulation with R848 that correlated with reduced lactate levels in the glioma cell coculture and a blockade of signal transducers and activators of transcription 3 phosphorylation. In vivo, diclofenac treatment diminished intratumoral lactate levels and resulted in a significant delay of glioma growth. Ex vivo analyses revealed that tumor‐infiltrating DCs regained their capacity to produce IL‐12 on R848 stimulation. Moreover, diclofenac reduced the number of tumor‐infiltrating regulatory T cells and impaired the upregulation of the Treg activation marker CD25. Nevertheless, a single intratumoral injection of R848 combined with diclofenac failed to induce an additional survival advantage in glioma‐bearing mice. Further analyses illustrated that the presence of diclofenac during T‐cell activation compromised INF‐γ production and T‐cell proliferation, indicating that immunotherapeutic approaches have to be carefully timed when combined with diclofenac. In summary, diclofenac appears as an attractive agent for targeting lactate production and counteracting local immune suppression in malignant gliomas.
Differences in human papillomavirus type distribution in high‐grade cervical intraepithelial neoplasia and invasive cervical cancer in Europe
Authors: Tjalma Wiebren A. , Fiander Alison , Reich Olaf , Powell Ned , Nowakowski Andrzej M. , Kirschner Benny , Koiss Robert , O'Leary John , Joura Elmar A. , Rosenlund Mats , Colau Brigitte , Schledermann Doris , Kukk Kersti , Damaskou Vasileia , Repanti Maria , Vladareanu Radu , Kolomiets Larisa , Savicheva Alevtina , Shipitsyna Elena , Ordi Jaume , Molijn Anco , Quint Wim , Raillard Alice , Rosillon Dominique , De Souza Sabrina Collas , Jenkins David , Holl Katsiaryna ,   for the HERACLES/SCALE Study Group
Published: July 2012

AbstractKnowledge of differences in human papillomavirus (HPV)‐type prevalence between high‐grade cervical intraepithelial neoplasia (HG‐CIN) and invasive cervical cancer (ICC) is crucial for understanding the natural history of HPV‐infected cervical lesions and the potential impact of HPV vaccination on cervical cancer prevention. More than 6,000 women diagnosed with HG‐CIN or ICC from 17 European countries were enrolled in two parallel cross‐sectional studies (108288/108290). Centralised histopathology review and standardised HPV‐DNA typing were applied to formalin‐fixed paraffin‐embedded cervical specimens dated 2001–2008. The pooled prevalence of individual HPV types was estimated using meta‐analytic methods. A total of 3,103 women were diagnosed with HG‐CIN and a total of 3,162 with ICC (median ages: 34 and 49 years, respectively), of which 98.5 and 91.8% were HPV‐positive, respectively. The most common HPV types in women with HG‐CIN were HPV16/33/31 (59.9/10.5/9.0%) and in ICC were HPV16/18/45 (63.3/15.2/5.3%). In squamous cell carcinomas, HPV16/18/33 were most frequent (66.2/10.8/5.3%), and in adenocarcinomas, HPV16/18/45 (54.2/40.4/8.3%). The prevalence of HPV16/18/45 was 1.1/3.5/2.5 times higher in ICC than in HG‐CIN. The difference in age at diagnosis between CIN3 and squamous cervical cancer for HPV18 (9 years) was significantly less compared to HPV31/33/‘other’ (23/20/17 years), and for HPV45 (1 year) than HPV16/31/33/‘other’ (15/23/20/17 years). In Europe, HPV16 predominates in both HG‐CIN and ICC, whereas HPV18/45 are associated with a low median age of ICC. HPV18/45 are more frequent in ICC than HG‐CIN and associated with a high median age of HG‐CIN, with a narrow age interval between HG‐CIN and ICC detection. These findings support the need for primary prevention of HPV16/18/45‐related cervical lesions.
PROFILE OF EMPLOYMENT SERVICE COUNSELORS
Authors: Sudweeks Leslie L. 
Published: July 2012

ABSTRACTAs a guide to program planning, the United States Employment Service makes periodic surveys of the numbers and characteristics of counseling staff employed by the various State Employment Services. The information obtained from these studies helps to provide answers to many administrative questions regarding recruitment, staffing, training, and utilization of counselors as well as their physical facilities. The most recent survey indicates that overall substantial progress has been made in staffing to meet increasing responsibilities and in upgrading the professional qualifications of counselors, although there are still some problem areas.
CONGRUENCE OF WORK‐RELATED NEEDS AND ABILITIES: TRANSITIONAL PSYCHIATRIC PATIENTS AND NORMALS1
Authors: Purvis Sharon A. 
Published: July 2012

ABSTRACTWork‐related needs and abilities appear to be significant factors in the vocational adjustment of psychiatric patients. When vocationally oriented patients were compared to a carefully matched normal sample, the patients were found to have significantly less agreement between their work needs and their work abilities. Although no difference was found to exist between the work needs of the patients and the matched normals, the work‐related abilities of the patients were distinctly lower than those of the normal population, implying that the appropriate focus of vocational rehabilitation counseling is the augmentation of patient assets. Persons most likely to have incongruity vocationally between their needs and abilities are male psychiatric patients, aged 24 to 36, who have less than a high school education.