bluuebunny/crossref_metadata_2025_split huggingface dataset:
Early complications of total hip and knee replacement: a comparison of outcomes in a regional orthopaedic hospital and two independent treatment centres
Authors: Bannister Gordon , Ahmed Mansoor , Bannister Miles , Bray Rachel , Dillon Paul , Eastaugh-Waring Stephen 
Published: September 2010

INTRODUCTION There is anecdotal evidence of poorer outcomes from prosthetic joint replacement performed in independent eatment centres but very few comparative studies. PATIENTS AND METHODS We compared the early re-operation, dislocation, re-admission, major wound infection and audit rates of 880 total hip (THA) and 874 total knee (TKA) arthroplasties carried out at a regional orthopaedic hospital (Avon Orthopaedic Centre; AOC) with 368 THAs and 365 TKAs from an NHS (WGH) and 67 THAs and 86 TKAs from a private hospital (CNH) independent treatment centre. RESULTS Early re-operation rates were 9% at CNH, 1.4% at WGH and 0.6% at AOC after THA and 8% at CNH, 1.9% at WGH and 1% at AOC after TKA. After THA, dislocation rates after THA were 6% at CNH and 1.8% at both WGH and AOC. Re-admission rates were 13% at CNH, 0.6% at WGH and 1.2% at AOC. Major wound problems were 20% at CNH, 3.8% at WGH and 0.4% at AOC after THA and 19% at CNH, 1.9% at WGH and AOC (1.1%) after TKA. After TKA, re-admission rates from CNH were 13%, 1% at WGH and 1.1% at AOC. AOC and WGH audited their outcomes. None were available from CNH. CONCLUSIONS Results and audit from independent treatment centres are variable and patients should be warned of this before undergoing treatment at them.
Hand surgery after axillary lymph node clearance for breast cancer: contra-indication to surgery?
Authors: Fulford Dean , Dalal Sam , Winstanley John , Hayton Mike J 
Published: September 2010

INTRODUCTION Breast cancer patients who have had prior axillary lymph node clearance (ALNC) can present with ipsi lateral hand conditions that could easily be treated with surgical intervention. These patients are often advised to avoid interventional procedures due to risks of complications such as lymphoedema, infection and cellulitis. SUBJECTS AND METHODS Between April and June 2009, we conducted an online survey of hand surgeons, breast surgeons and breast-care nurses to obtain their views on hand surgery after ipsilateral axillary lymph node clearance. RESULTS The majority of hand surgeons (58%) felt there was no contra-indication to surgery in a breast cancer patient with prior ipsilateral ALNC compared to just 30% of breast surgeons and 10% of breast-care nurses. The majority of breast surgeons and breast-care nurses (70% and 89%, respectively) felt that hand surgery was a relative contra-indication compared to just 41% of hand surgeons. Postoperative lymphoedema was the commonest cited reason for avoiding surgery. The majority of hand surgeons (79%) and nearly two-thirds of breast surgeons (57%) would use a tourniquet during surgery if it was normal practice. CONCLUSIONS A review of the published literature does not support the notion that these patients experience increased complications; therefore, we recommend the advice given to breast cancer patients regarding ipsilateral surgery be re-evaluated.
Emotion regulation difficulties are relevant to persecutory ideation
Authors: Westermann Stefan , Lincoln Tania M. 
Published: September 2010

Objectives. Persecutory delusions are preceded and accompanied by negative emotions, which may be prolonged or even amplified by difficulties in the ability to regulate negative emotions. This study aims to gain insight into emotion regulation difficulties in persecutory ideation. Design and method. A correlational approach was adopted to explore bivariate and multivariate associations between emotion regulation difficulties and persecutory ideation in a subclinical sample. Furthermore, general psychopathology as well as positive symptoms of schizophrenia were assessed in order to estimate the specificity of emotion regulation difficulties. Data from 151 participants acquired via an Internet‐based survey were analyzed. Results. There were substantial bivariate correlations between paranoid ideation and emotion regulation difficulties. However, only impulse control difficulties were specific to persecutory ideation after controlling for general psychopathology. Additionally, a multivariate analysis revealed unexpected positive associations between the acceptance of emotional responses and paranoid ideation as well as positive symptoms. Conclusions. Besides the general difficulties in regulating emotion that are common to many clinical disorders and were associated with overall psychopathology, subclinical psychotic symptoms seem to be specifically associated with certain aspects of emotion regulation. Emotion regulation difficulties are likely to contribute to symptom formation and maintenance in persecutory delusions and might therefore present a valuable treatment target.
Kinetic and structural characterization of bacterial glutaminyl cyclases from Zymomonas mobilis and Myxococcus xanthus
Authors: Carrillo David Ruiz , Parthier Christoph , Jänckel Nadine , Grandke Julia , Stelter Marco , Schilling Stephan , Boehme Mathias , Neumann Piotr , Wolf Raik , Demuth Hans-Ulrich , Stubbs Milton T. , Rahfeld Jens-Ulrich 
Published: September 2010

AbstractAlthough enzymes responsible for the cyclization of amino-terminal glutamine residues are present in both plant and mammal species, none have yet been characterized in bacteria. Based on low sequence homologies to plant glutaminyl cyclases (QCs), we cloned the coding sequences of putative microbial QCs fromZymomonas mobilis(ZmQC) andMyxococcus xanthus(MxQC). The two recombinant enzymes exhibited distinct QC activity, with specificity constantskcat/Kmof 1.47±0.33 mm-1s-1(ZmQC) and 142±32.7 mm-1s-1(MxQC) towards the fluorescent substrate glutamine-7-amino-4-methyl-coumarine. The measured pH-rate profile of the second order rate constant displayed an interesting deviation towards the acidic limb of the pH chart in the case of ZmQC, whereas MxQC showed maximum activity in the mild alkaline pH range. Analysis of the enzyme variants ZmQCGlu46Gln and MxQCGln46Glu show that the exchanged residues play a significant role in the pH behaviour of the respective enzymes. In addition, we determined the three dimensional crystal structures of both enzymes. The tertiary structure is defined by a five-bladed β-propeller anchored by a core cation. The structures corroborate the putative location of the active site and confirm the proposed relation between bacterial and plant glutaminyl cyclases.
The C2-streptavidin delivery system promotes the uptake of biotinylated molecules in macrophages and T-leukemia cells
Authors: Fahrer Jörg , Rieger Julia , van Zandbergen Ger , Barth Holger 
Published: September 2010

AbstractMacrophages are tightly associated with inflammatory diseases as well as carcinogenesis, and therefore represent promising targets for drug delivery and gene transfer. We have recently established a novel protein delivery system based on the binary C2 toxin ofClostridium botulinumand streptavidin, allowing the uptake of exogenous biotinylated molecules into mammalian cells. Here, we applied this C2-streptavidin delivery system to macrophages and other leukocytes. First, the effect of wild-type C2 toxin on different leukocyte cell lines was tested, indicating no differences in sensitivity. Next, the uptake and stability of the engineered C2-streptavidin was analyzed in macrophages and Jurkat T-cells, showing internalization into the cytosol of both cell types with similar kinetics. The transporter did not exhibit any cytotoxic effect and did not interfere with phagocytosis in primary human macrophages. The C2-streptavidin system promoted specific uptake of biotinylated fluorophores into the cytosol of macrophages as revealed by confocal microscopy. In addition, flow cytometry analysis showed a significantly enhanced uptake of biotinylated fluorescent tracers in Jurkat leukemia cells mediated by the C2-streptavidin transporter. Our results demonstrate that C2-streptavidin is a functional delivery system for transport of biotinylated molecules into macrophages and other leukocytes without compromising cell viability and intrinsic functions such as phagocytosis.
Acute and long-term effects of metformin on the function and insulin secretory responsiveness of clonal β-cells
Authors: McKiney Joan M. , Irwin Nigel , Flatt Peter R. , Bailey Clifford J. , McClenaghan Neville H. 
Published: September 2010

Abstract
Functional effects of acute and prolonged (48 h) exposure to the biguanide drug metformin were examined in the clonal pancreatic β-cell line, BRIN-BD11. Effects of metformin on prolonged exposure to excessive increased concentrations of glucose and palmitic acid were also assessed. In acute 20-min incubations, 12.5–50 μm metformin did not alter basal (1.1 mm glucose) or glucose-stimulated (16.7 mm glucose) insulin secretion. However, higher concentrations of metformin (100–1000 μm) increased (1.3–1.5-fold; p<0.001) insulin release at basal glucose concentrations, but had no effect on glucose-stimulated insulin secretion. There were no apparent acute effects of metformin on intracellular Ca2+ concentrations, but metformin enhanced (p<0.05 to p<0.01) the acute insulinotropic actions of GIP and GLP-1. Exposure for 48 h to 200 μm metformin improved aspects of β-cell insulin secretory function, whereas these benefits were lost at 1 mm metformin. Prolonged glucotoxic and lipotoxic conditions impaired β-cell viability and insulin release in response to glucose and to a broad range of insulin secretagogues. Concomitant culture with 200 μm metformin partially reversed many of the adverse effects of prolonged glucotoxic conditions. However, there were no beneficial effects of metformin under prolonged culture with elevated concentrations of palmitic acid. The results suggest that metformin exerts direct effects on β-cell viability, function and survival that could contribute to the use of this agent in the treatment of type 2 diabetes.
Cantares Mexicanos: Songs of the Aztecs/A Nahuatl‐English Dictionary and Concordance to the Cantares Mexicanos
Authors: Brody Jill 
Published: September 2010

Cantares Mexicanos: Songs of the Aztecs. John Bierhorst. Stanford: Stanford University Press, 1985. Xiv. 559 pp. $48.50 (Cloth). ISBN 0‐8047‐ 1182‐8. Nahuatl‐English Dictionary and Concordance to the Cantares Mexicanos. John Bierhorst Stanford: Stanford University Press, 1985. 760 pp. $69.50 (Cloth) ISBN 0‐8047‐1183‐6
The Serpent and the Rainbow/The Passage of Darkness
Authors: Lawless Robert 
Published: September 2010

The Serpent and the Rainbow:. Harvard Scientist Uncovers the Startling Truth about the Secret World of Haitian Voodoo and Zombis. Wade Davis. Warner Books, 1987.384 pp. $4.95 (paper). ISBN 0‐446‐34387‐0Passage of Darkness: The Ethnoblology of the Haitian Zombie. Wade Davis. Chapel Hill: University of North Carolina Press, 1988. xxi+344 pp. $29.95 (Cloth). ISBN 0‐8078‐1776‐7; $9.95(paper). ISBN 0‐8078‐4210‐9
White Servitude and Black Slavery in Barbados, 1627–1715
Authors: Sookdeo Anil 
Published: September 2010

White Servitude and Black Slavery in Barbados, 1627‐1715. Hilary Mcd. Beckles. Knoxville: University of Tennessee Press, 1989. 218 pp. $34.95 (cloth). ISBN 0‐87049‐601‐8.The Plantation Slaves of Trinidad,1783‐1816: A Mathematical and Demographic Study. A.Meredith John Cambridge: Cambridge University Press, 1988. 259 pp. $42.50 (cloth). ISBN 0‐521‐36166‐4.
Some Write to the Future: Essays on Contemporary Latin American Fiction
Authors: Klein Scott 
Published: September 2010

Some Write to the Future: Essays on Contemporary Latin American Fiction, Ariel Dorfman. Translated by George Shivers with the author. Durham and London: Duke University Press. 1991. xiv + 255pp. $24.95 (cloth). ISBN 0–8223–1130–5.Do the Americas Have a Common Literature? Gustavo Pérez Firmat (editor). Durham and London: Duke University Press. 1990. ix + 394 pp. $19.95 (paper). ISBN 0–8223–1072–4.
Industrialization in Mexico
Authors: Hopgood James F. 
Published: September 2010

Entrepreneurs and Politics in Twentieth‐Century Mexico. Roderic A. Camp. New York: Oxford University Press, 1989. xiv + 306 pp., notes, bibliographic essay, index. $37.00 (cloth). ISBN 0–19–505719–8.Industry and Underdevelopment: The Industrialization of Mexico, 1890‐1940. Stephen H. Haber. Stanford: Stanford University Press, 1989. xv + 237 pp., notes, bibliography, index. $37.50 (cloth). ISBN 0‐8047‐1487‐8.The Monterrey Elite and the Mexican State, 1880‐1940. Alex M. Saragoza. Austin: University of Texas Press, 1988. x + 258 pp., notes, selected bibliography, index. $12.95 (cloth). ISBN 0‐292‐71113‐1.
The Maya and the Gringos Many “Unfinished Conversations”
Authors: Passariello Phyllis 
Published: September 2010

Unfinished Conversations: Maya and Foreigners between Two Wars. Paul Sullivan. Berkeley:University of California Press, 1991. 269 pp. $12.95 (paper). ISBN 0–520–07244–8.Deserted Cities of the Heart. Lewis Shiner. New York: Bantam, 1991. 352 pp. $4.50 (paper). ISBN 0–553–35457–4.Gringos. Charles Portis. New York: Simon and Schuster, 1991. 278 pp. $18.95 (cloth). ISBN 0–67172–457–6.The Long Night of White Chickens. Francisco Goldman. New York: Atlantic Monthly Press, 1992. 450 pp. $12.00 (paper). ISBN 0–87113–541–8.
The Women's Movement in Latin America: Feminism the Transition to Democracy; Women and Social Change in Latin America
Authors: Mujica Maria‐Elena 
Published: September 2010

The Women's Movement in Latin America: Feminism and the Transition to Democracy. Jane Jaquette (editor). Boulder: Westview Press, 1989. 224 pp. $17.95 (paper). ISBN 0–8.133–1293–0.Women and Social Change in Latin America. Elizabeth Jelín (editor). London: Zed Books, 1990. 256 pp. $15.00 (paper). ISBN 0–86232–871–3.
Political Forces in Argentina, 3rd edition; The New Argentine Democracy: The Search for a Successful Formula
Authors: Clohesy William 
Published: September 2010

Political Forces in Argentina, 3rd edition. PETER G. SNOW and LUIGI MANZETTI. Westport, London: Praeger,1993.183 pp. $49.95 (cloth), $17.95 (paper). ISBN 0‐275‐93384‐9, ISBN 0‐275‐93810‐7.The New Argentine Democracy: The Search for a Successful Formula. EDWARD C. EPSTEIN (editor). Westport, London: Praeger, 1992. 296 pp. $55.00 (cloth). ISBN 0–275–93919–7.
Beyond Regulation: The Informal Economy in Latin America; Contrapunto: The Informal Sector Debate in Latin America
Authors: Wilson Tamar Diana 
Published: September 2010

Beyond Regulation: The Informal Economy in Latin America. VICTOR E. TOKMAN (editor). Boulder: Lynne Rienner Publishers, 1992. viii + 295 pp. $38.00 (cloth). ISBN 1–55587–318–9.Contrapunto: The Informal Sector Debate in Latin America. CATHY A. RAKOWSKI (editor). Albany: State University of New York Press, 1994. xi + 336 pp. $21.95 (paper), $64.00 (cloth). ISBN‐0‐7914‐1906‐1, ISBN 0‐7914‐1905‐3.
Landscapes of a New Land: Fiction by Latin American Women; Short Stories by Latin American Women: The Magic and the Real
Authors: Lacy‐Salazar Carol 
Published: September 2010

Landscapes of a New Land: Fiction by Latin American Women. MARJORIE AGOSIN (editor). Buffalo: White Pine Press, 1989. 194 pp., biographies. $12.00 (paper). ISBN 0–934834–96–2.Short Stories by Latin American Women: The Magic and the Real. CELIA CORREAS de ZAPATA (editor). Houston: Arte Publico Press, 1990. 224 pp., biographies. $13.50 (paper). ISBN 1–55885–002–3.
Kings and Kin groups: The Evolution and Devolution of States
Authors: Becker Marshall Joseph 
Published: September 2010

Mesoamerican Elites: An Archaeological Assessment. Diane Z. Chase and Arlen F. Chase (editors). Norman: University of Oklahoma Press, 1992. xiv + 375 pp., illustrations, bibliography, index, figures, tables. $39.95 (cloth), $15.95 (paper). ISBN 0‐0861‐2371‐0, ISBN 0‐8061‐2666‐3.War in the Tribal Zone: Expanding States and Indigenous Warfare. Brian Ferguson and Neil L. Whitehead (editors). Santa Fe: School of American Research Advanced Seminar Series, 1992. xiv + 303 pp. $35.00 (cloth), $15.95 (paper). ISBN 0‐933452‐79‐9, ISBN 0‐933452‐80‐2.Craft and the Kingly Ideal: Art, Trade, and Power. Mary W. Helms. Austin: University of Texas Press,1993. xii + 287pp. $42.50 (cloth), $18.95 (paper). ISBN 0‐292‐73074‐8, ISBN 0‐292‐73078‐0.
The role of selective venous sampling in the management of persistent hyperparathyroidism revisited
Authors: Witteveen Janneke E , Kievit Job , van Erkel Arian R , Morreau Hans , Romijn Johannes A , Hamdy Neveen A T 
Published: September 2010

IntroductionLocalization studies are mandatory prior to revision surgery in patients with persistent hyperparathyroidism in order to improve surgical outcome and reduce the risk of lengthy explorations. However, in this case, noninvasive localization studies are reported to have a poor sensitivity. The aim of our study is to determine the accuracy of selective venous sampling (SVS) for parathyroid hormone (PTH) in localizing residual hyperactive parathyroid glands in patients with persistent or recurrent hyperparathyroidism.Patients and methodsWe retrospectively evaluated the localizing accuracy of 20 PTH SVS performed prior to revision surgery in 18 patients with persistent or recurrent primary hyperparathyroidism (n=11) or autonomous (tertiary) hyperparathyroidism (n=7). Tc99m-methoxy-isobutyle-isonitrile (MIBI)-single photon emission computed tomography (SPECT) was also performed in all patients prior to revision surgery. Operative and pathological data were obtained from hospital records.ResultsThe SVS was able to accurately localize 15 of the 20 pathological glands removed at revision surgery, representing a sensitivity of 75%. This sensitivity is significantly higher than that of Tc99m-MIBI-SPECT, which was only 30% (P=0.012).ConclusionOur findings demonstrate that SVS is a valuable localization study in patients with persistent or recurrent hyperparathyroidism, with a sensitivity significantly higher than that of Tc99m-MIBI-SPECT. Our data suggest that SVS represents a useful addition to the preoperative workup of these patients prior to revision surgery.
Results of a Community-Based Randomized Trial to Increase Colorectal Cancer Screening Among Filipino Americans
Authors: Maxwell Annette E. , Bastani Roshan , Danao Leda L. , Antonio Cynthia , Garcia Gabriel M. , Crespi Catherine M. 
Published: September 2010

Objectives. We conducted 1 of the first community-based trials to develop a multicomponent intervention that would increase colorectal cancer screening among an Asian American population. Methods. Filipino Americans (n = 548) nonadherent to colorectal cancer (CRC) screening guidelines were randomized into an intervention group that received an education session on CRC screening and free fecal occult blood test (FOBT) kits; a second intervention group that received an education session but no free FOBT kits; and a control group that received an education session on the health benefits of physical activity. Results. Self-reported CRC screening rates during the 6-month follow-up period were 30%, 25%, and 9% for participants assigned to intervention with FOBT kit, intervention without the kit, and control group, respectively. Participants in either of the 2 intervention groups were significantly more likely to report screening at follow-up than were participants in the control group. Conclusions. A multicomponent intervention that includes an educational group session in a community setting can significantly increase CRC screening among Filipino Americans, even when no free FOBT kits are distributed.
Burden of Mortality Associated With Autoimmune Diseases Among Females in the United Kingdom
Authors: Thomas Sara L. , Griffiths Clare , Smeeth Liam , Rooney Cleo , Hall Andrew J. 
Published: September 2010

Objectives. We estimated the collective burden of mortality from autoimmune diseases among females in the United Kingdom and the effects of death certificate coding changes on this estimate. Methods. We analyzed 1993–2003 England and Wales death certificate data for 3 150 267 females aged 1 year or older. We identified death certificates that listed autoimmune conditions as underlying or contributory causes of death. The percentages of all female deaths attributed to autoimmune disorders and to UK official mortality categories were ranked to determine the leading causes of death. Results. In 2003, autoimmune diseases were the sixth or seventh most frequent underlying cause of death among females in all age groups below 75 years. Results were similar when both underlying and contributory causes of death were considered. The proportion of females dying with an autoimmune disorder remained relatively constant from 1993 to 2003. Analyses indicated that death counts for specific autoimmune diseases had been underestimated. Conclusions. Autoimmune diseases are a leading cause of death among females in England and Wales, but their collective impact remains hidden in current disease classification systems. Grouping these disorders together may help promote research needed to identify common determinants and future prevention strategies.
Obstetrical Intervention and the Singleton Preterm Birth Rate in the United States From 1991–2006
Authors: MacDorman Marian F. , Declercq Eugene , Zhang Jun 
Published: September 2010

Objectives. We examined the relationship between obstetrical intervention and preterm birth in the United States between 1991 and 2006. Methods. We assessed changes in preterm birth, cesarean delivery, labor induction, and associated risks. Logistic regression modeled the odds of preterm obstetrical intervention after risk adjustment. Results. From 1991 to 2006, the percentage of singleton preterm births increased 13%. The cesarean delivery rate for singleton preterm births increased 47%, and the rate of induced labor doubled. In 2006, 51% of singleton preterm births were spontaneous vaginal deliveries, compared with 69% in 1991. After adjustment for demographic and medical risks, the mother of a preterm infant was 88% (95% confidence interval [CI] = 1.87, 1.90) more likely to have an obstetrical intervention in 2006 than in 1991. Using new birth certificate data from 19 states, we estimated that 42% of singleton preterm infants were delivered via induction or cesarean birth without spontaneous onset of labor. Conclusions. Obstetrical interventions were related to the increase in the US preterm birth rate between 1991 and 2006. The public health community can play a central role in reducing medically unnecessary interventions.
Mortality Patterns of Native Hawaiians Across Their Lifespan: 1990–2000
Authors: Panapasa Sela V. , Mau Marjorie K. , Williams David R. , McNally James W. 
Published: September 2010

Objectives. We examined mortality patterns across the lifespan of Native Hawaiians and compared mortality disparities across races. Methods. We determined the age-specific and age-adjusted mortality rates of Native Hawaiians from 1990 to 2000 by using national census and vital registration data. Results. Among Native Hawaiians aged younger than 1 year, expected deaths were 15% lower than for Blacks and 50% higher than for Whites. Among older adults, Native Hawaiians had higher rates of mortality compared with the general population, particularly in 1990 and 1995. Crude death rates for Native Hawaiians were similar to those for Blacks in 1990 and 1995 but were 20% lower than those for Blacks by 2000. Crude death rates for Native Hawaiians were 30% higher than for Whites in 1990 and 1995 and more than 40% higher than for Whites in 2000. Conclusions. Compared with Whites, Native Hawaiians and Blacks face similar challenges regarding infant and early-life mortality and increasing risks of mortality in mid-life and early old age. Our analyses document a need for renewed efforts to identify the determinants of ill health and commitment to address them.