bluuebunny/crossref_metadata_2025_split huggingface dataset:
Multiple time servers timed-release encryption based on Shamir secret sharing for EHR cloud system
Authors: Yuan Ke , Cheng Ziwei , Chen Keyan , Wang Bozhen , Sun Junyang , Zhou Sufang , Jia Chunfu 
Published: June 2024

AbstractElectronic health record (EHR) cloud system, as a primary tool driving the informatization of medical data, have positively impacted both doctors and patients by providing accurate and complete patient information. However, ensuring the security of EHR cloud system remains a critical issue. Some patients require regular remote medical services, and controlling access to medical data involving patient privacy during specific times is essential. Timed-release encryption (TRE) technology enables the sender to preset a future time T at which the data can be decrypted and accessed. It is a cryptographic primitive with time-dependent properties. Currently, mainstream TRE schemes are based on non-interactive single time server methods. However, if the single time server is attacked or corrupted, it is easy to directly threaten the security applications of TRE. Although some research schemes “distribute” the single time server into multiple ones, they still cannot resist the single point of failure problem. To address this issue, we propose a multiple time servers TRE scheme based on Shamir secret sharing and another variant derived from it. In our proposed schemes, the data receiver does not need to interact with the time servers; instead, they only need to obtain the time trapdoors that exceed or equal the preset threshold value for decryption, which ensures the identity privacy of the data sender and tolerates partial downtime or other failures of some time servers, significantly improving TRE reliability. Security analysis indicates that our proposed schemes demonstrate data confidentiality, verifiability, anti-advance decryption, and robust decryption with multiple time trapdoors, making them more practical. Efficiency analysis indicates that although our schemes have slightly higher computational costs than most efficient existing TRE schemes, such differences are insignificant from a practical application perspective.
Association between estimated glucose disposal rate and atrial fibrillation recurrence in patients undergoing radiofrequency catheter ablation: a retrospective study
Authors: Li Xiaozhong , Zhou Zheng , Xia Zhen , Dong Youzheng , Chen Si , Zhan Fenfang , Wang Zhichao , Chen Yang , Yu Jianhua , Xia Zirong , Li Juxiang 
Published: June 2024

Abstract
Objective
Previous studies have shown a clear link between insulin resistance (IR) and an elevated risk of atrial fibrillation (AF). However, the relationship between the estimated glucose disposal rate (eGDR), which serves as a marker for IR, and the risk of AF recurrence after radiofrequency catheter ablation (RFCA) remains uncertain. Therefore, this study aimed to examine the potential association between the eGDR and the risk of AF recurrence following RFCA.

Methods
This retrospective study was conducted at Nanchang University Affiliated Second Hospital. The study enrolled 899 patients with AF who underwent RFCA between January 2015 and January 2022. The formula used to calculate the eGDR was as follows: 19.02 − (0.22 * body mass index) − (3.26 * hypertension) − (0.61 * HbA1c). Cox proportional hazard regression models and exposure–effect curves were used to explore the correlation between the baseline eGDR and AF recurrence. The ability of the eGDR to predict AF recurrence was evaluated using the area under the receiver operating characteristic curve (AUROC).

Results
The study observed a median follow-up period of 11.63 months, during which 296 patients experienced AF recurrence. K‒M analyses revealed that the cumulative incidence AF recurrence rate was significantly greater in the group with the lowest eGDR (log-rank p < 0.01). Participants with an eGDR ≥ 8 mg/kg/min had a lower risk of AF recurrence than those with an eGDR < 4 mg/kg/min, with a hazard ratio (HR) of 0.28 [95% confidence interval (CI) 0.18, 0.42]. Additionally, restricted cubic spline analyses demonstrated a linear association between the eGDR and AF recurrence (p nonlinear = 0.70). The area under the curve (AUC) for predicting AF recurrence using the eGDR was 0.75.

Conclusions
The study revealed that a decrease in the eGDR is associated with a greater AF recurrence risk after RFCA. Hence, the eGDR could be used as a novel biomarker for assessing AF recurrence risk.
Dropout intention: a valid predictor of actual dropout?
Authors: Findeisen Stefanie , Brodsky Alexander , Michaelis Christian , Schimmelpenningh Beatrice , Seifried Jürgen 
Published: June 2024

AbstractEvidence on the extent to which dropout intention can serve as a valid predictor of dropout decisions remains scarce. This study first presents the results of a systematic literature review of 14 studies examining the relationship between dropout intention and actual dropout in post-secondary education (vocational education and training [VET] or higher education). Second, we examine a longitudinal dataset of prospective chefs surveyed at the beginning (t1), the second half of the first year (t2), and the second year of the dual VET programme (t3). We examine the relationship between self-reported dropout intention and trainees’ actual dropout behaviour. Additionally, we analyse development profiles of trainees’ dropout intention using latent profile analysis. The review results provide strong support for a significant positive relationship between dropout intention and actual dropout (effect sizes vary between studies and contexts/types of dropout). In line, aspiring chefs’ dropout intention is significantly positively correlated with actual dropout (r = 0.201). Three development profiles were identified during VET: (1) stable, low dropout intention, (2) stable, medium dropout intention, and (3) increasing dropout intention. We conclude that dropout intention is positively related to actual dropout. As the extent to which dropout intention actually leads to dropout behaviour in VET also depends on external factors (e.g., labour market situation, alternative options), the predictive power of dropout intention may be limited. This is suggested by the weak correlation between dropout intention and actual dropout and the profile of trainees with increasing dropout intention who nevertheless persisted until year 2 of VET.
Effects of different tooth grinding procedures on the occurrence of tooth injuries, skin lesions, performance and behaviour of suckling piglets
Authors: kleine Kruthaup Franziska Anna , Fels Michaela , Timphaus Carolin Bernarda , Freise Fritjof , Herbrandt Swetlana , große Beilage Elisabeth 
Published: June 2024

AbstractBackgroundImmediately after birth, newborn piglets fight to establish a teat order. During this process, lesions appear on the piglets’ faces and on the sows’ teats, which is why tooth resection is carried out on many farms in Germany even though it is known that this procedure is frequently resulting in pulp openings. The opening of a pulp cave is suspected to cause painful tooth alterations and may be an entrance for infectious agents. The purpose of this study was to analyse the effect of tooth resection on skin lesions, development of bodyweight and behaviour in suckling piglets. Four days prepartum, 110 sows in farrow-to-finish production were assigned to one of three treatments. Litters had their teeth left intact (control group, CG), ground with a tea-cup roller head (Tea-cup head grinder group, TCG, Wilofa Diamant, D-56,133 Fachbach, Germany) or ground with a diamond rolling head (rolling head grinder group, RG, IBS/E Company Proxxon GmbH, 54,343 Föhren, Germany). The number of pulp openings in the RG and TCG was examined using a random sample. Piglet body weight and skin lesion scores were recorded within the first 24 h after birth and during each week of the suckling period. Each sow’s udder was examined before farrowing, in the second week of lactation and at weaning. The behaviour of the litters from nine sows was video-recorded throughout the suckling period. The aim of this study was to investigate the effects of tooth grinding by a tea-cup head (compared to grinding by a diamond roller head and no grinding [control group]) on the behaviour and average daily gain of piglets as well as on skin lesions on sow udder.ResultsThe number of dental injuries was significantly greater in the RG than in the TCG (p < 0.01). Head lesions on piglets were significantly more common in the CG than in the RG (p = 0. 02). Compared to CG piglets, TCG piglets had a significantly greater weight at the end of the suckling period (p = 0.02). No significant difference between treatments was found in the sows’ udder (parenchyma, skin, or teat) or in the behaviour of the litters.ConclusionAs tooth grinding is frequently inducing pulp openings, the necessity of the procedure should be carefully and critically scrutinised. In case tooth resection seems inevitable until the underlying management problems have been solved, the Tea-cup grinding head should be used due to significantly fewer pulp openings.
Determining the vitamin D supplementation duration to reach an adequate or optimal vitamin D status and its effect on blood lipid profiles: a longitudinal study
Authors: Saeidlou Sakineh Nouri , Vahabzadeh Davoud , Karimi Fozieh , Babaei Fariba 
Published: June 2024

Abstract
Background
Recently, Serum vitamin D (Vit. D) levels evaluation and the use of Vit. D supplements have increased substantially. There is no specific guideline for the duration of Vit. D supplementation, so yet Vit. D supplementation duration has remained a critical and controversial issue. This study aimed to determine the vit. D supplementation duration to reach an adequate or optimal Vit. D status and its effect on lipid profile.

Methods
In this longitudinal study, 345 women with different status of Vit. D levels were enrolled and followed up for one year. Eligible participants received 50,000 IU Vit. D3 (cholecalciferol) once a month for 12 consecutive months. The serum Vit. D levels and lipid profiles were measured at baseline, 3rd, 6th, and 12th months after the intervention. Participants were categorized based on Vit. D level at baseline into deficiency (< 20 ng/mL), inadequate (20–30 ng/mL), and adequate (> 30 ng/mL) groups, and the data were compared at different times between the three groups.

Results
Three deficiency (n = 73), inadequate (n = 138) and adequate (n = 134) groups of participants were followed. In all participants the average amount of Vit. D level changes were 8 ng/mL after one year of supplementation. The mean changes of serum Vit. D level in 6th and 12th months vs. 3th month was as below: In deficiency group: 4.08 ± 0.85 and 10.01 ± 1.02 ng/mL; (p < 0.001), in inadequate group: 3.07 ± 0.59 and 7.26 ± 0.78 ng/mL; (p = 0.001) and in adequate group: 2.02 ± 0.88 and 6.44 ± 1.005 ng/ml; (p = 0.001). Lipid profiles were improved in three groups. So, the mean changes of lipid profiles at the end of the study comparing with the baseline were: -5.86 ± 2.09, -7.22 ± 1.43 and − 6.17 ± 1.72 (mg/dl) for LDL (p < 0.05); -12.24 ± 3.08, -13.64 ± 3.21 and − 17.81 ± 2.94 (mg/dl) for cholesterol (p < 0.05) in deficiency, inadequate and adequate groups, respectively. For triglyceride, the mean changes were − 13.24 ± 5.78 and − 15.85 ± 7.49 (mg/dl) in deficiency and adequate groups, respectively (p < 0.05). Although the triglyceride decreased in the inadequate group at the end of the study but this difference was not significant (p = 0.67).

Conclusion
Taking of 50,000 IU Vit. D 3 monthly for 12 months resulted in reaching its level to adequate level in both deficiency and insufficient groups; however, in the adequate group its level did not reach above than 50 ng/mL. Therefore, 50,000 IU Vit. D3 supplementation monthly for one year can have beneficial effects on lipid profiles and there is no risk of toxicity in healthy women.
Global research trends on the relationship between IBD and CRC: a bibliometric analysis from 2000 to 2023
Authors: Zhang Hao , Xin Huiru , Zhao Mengqi , Bi Chenyang , Xiao Yafei , Li Yifan , Qin Changjiang 
Published: June 2024

Abstract
Objective
This study aimed to conduct a bibliometric analysis of research articles on the relationship between inflammatory bowel disease (IBD) and colorectal cancer (CRC) using CiteSpace to summarize the current research status, hotspots, and trends in this field and present the results visually.

Method
Research articles on the relationship between IBD and CRC published from 2000 to 2023 and in English were selected from the Web of Science Core Collection (Woscc) database. The articles were downloaded as “full record and references”. CiteSpace was used to conduct cooperative, cluster, co-citation, and burst analyses.

Results
The literature search revealed 4244 articles; of which, 5 duplicates were removed, resulting in the inclusion of 4239 articles in this study. The United States of America had the highest number of publications, with Mayo Clinic and Harvard University being the most active institutions, and Bas Oldenburg being the most active author. Collaboration among core authors was inadequate. JA Eaden was the most cited author, and CRC was the most common keyword. Burst analysis indicated that Sun Yat-sen University might be one of the institutions with a large contribution to this research field in the future. Cluster analysis showed that earlier research focused more on microsatellite instability, whereas “gut microbiota” and “oxidative stress” are considered current research hotspots and trends.

Conclusion
At present, the primary focus areas of research are “gut microbiota” and “oxidative stress”. With the improvement of healthcare policies and standards, regular endoscopic monitoring of patients with IBD has become an indispensable diagnostic and therapeutic practice. More drugs will be developed to reduce the risk of progression from IBD to CRC. The findings of this study provide valuable insights into the relationship between IBD and CRC for researchers in the same field.
The effect of forward head posture on dynamic lung volumes in young adults: a systematic review
Authors: Deniz Yasemin , Ertekın Damla , Cokar Dılek 
Published: June 2024

Abstract
Purpose
The study aimed to investigate whether there is a difference in pulmonary function between individuals with forward head posture and those with neutral head posture.

Methods
A systematic search was conducted using the ResearchGate, PubMed, and Scholar databases following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) protocol. The eligibility criteria for the studies were that they investigated the relationship between Forward Head Posture (FHP) and Forced Vital Capacity (FVC) and/or Forced Expiratory Volume in one second (FEV1).

Results
A total of four comparison studies and two correlation studies met the inclusion criteria for this study. Across these four studies, encompassing a total of 115 participants, the observed reduction range for FVC was between -0.25 L and -0.81 L, while the reduction values for FEV1 ranged from -0.16 to -0.93 L. According to the results of the correlation studies, a positive correlation was observed between craniovertebral angle (CVA) and dynamic pulmonary volumes.

Conclusion
The existing evidence indicates that FHP can potentially cause abnormalities in pulmonary function. In this context, it is suggested that individuals with FHP should be monitored for changes in pulmonary function.
Nanoplastics as emerging cardiovascular hazards: a narrative review of current evidence
Authors: Olatunji Gbolahan , Kokori Emmanuel , Ogieuhi Ikponmwosa Jude , Chidinma Udojike I. , Omoworare Oluwatobi , Olatunji Doyin , Oluwatomiwa Ajekiigbe Victor , Oyewale Oyebiyi Babajide , Dorcas Omotade Omolade , Zuhair Varisha , Shu Bonu Innocent , Stanley Anthony Chidera , Aderinto Nicholas 
Published: June 2024

Abstract
Background
Nanoplastics (NPs) have emerged as significant environmental pollutants, raising concerns due to their ubiquitous presence and potential adverse effects on human health. The migration and fate of NPs in the environment are subjects of intense study, with human exposure pathways expanding through ingestion, inhalation, and dermal contact.

Body
Studies indicate that NPs can infiltrate the cardiovascular system, potentially causing adverse effects. Mechanistic insights from in vitro and animal studies suggest that oxidative stress, inflammation, apoptosis, and mitochondrial dysfunction contribute to nanoplastic-induced cardiovascular toxicity. Animal models demonstrate altered heart rate, myocardial fibrosis, and dysfunction following NPs exposure, with specific adverse effects observed in cardiac valves and mitochondrial structure. Clinical studies provide further evidence of NPs accumulation in cardiovascular tissues, with implications for cardiovascular pathologies such as atherosclerosis and myocardial infarction. Notably, patients with higher levels of nanoplastics in carotid plaque exhibit an increased risk of adverse cardiovascular outcomes.

Conclusion
However, challenges in studying nanoplastics persist, including methodological limitations, ethical considerations, and the need for standardized detection methods. Addressing these challenges requires interdisciplinary collaboration, innovative research approaches, and robust regulatory measures to mitigate NPs pollution and protect cardiovascular health.
Variant of uncertain significance (VUS) genetic testing results and mastectomy choice in lumpectomy-eligible patients.
Authors: Nunez Jr. Osvaldo , Govind Vasanth , Wolde Tizeta M. , Heath Rainya , Donenberg Talia R. , Silva-Smith Rachel , Jeanjean Marie B. , Moore Jessica Firdman , Crystal Jessica S. , Kesmodel Susan , Rojas Kristin E. 
Published: June 2024

10601 Background: Germline variants of uncertain significance (VUS) should not change surgical decision-making in breast cancer (BC) patients based on current guidelines. We sought to evaluate whether VUS may drive surgical choice in lumpectomy-eligible BC patients. Methods: A single-institution retrospective analysis included breast surgery patients (2020-2021). ‘Lumpectomy-eligible’ was defined as unilateral cT0-2 BC, excluding those with pathogenic mutations. Descriptive analyses compared those undergoing lumpectomy or bilateral mastectomy (BLMast), accounting for testing results. Multivariate analysis to predict the likelihood mastectomy receipt was limited to tested patients without pathogenic mutations using binomial logistic regression. Results: Of 741 patients, 549 (74%) were lumpectomy-eligible and 326 received genetic testing (235 negative, 91 VUS). Median age was 55.0 (26 - 84). Of those tested, 206 underwent lumpectomy, and 58 underwent BLMast. Insurance type, race, ethnicity, language, tobacco use, marital status, and axillary management did not differ between groups. Compared to lumpectomy patients, a higher proportion with a VUS (40% vs 25%, p=0.026), AJCC Stage 2 disease (41% vs 31%, p=0.023), or with ≥ 2 MRI-recommended biopsies (31.3% vs 13.8%, p=0.021) underwent BLMast. Multivariate analysis found that VUS patients were twice as likely to undergo BLMast compared to those with negative testing (OR 2.213 95% CI 1.113-4.400, p=0.023) (Table). Young patients and those with more advanced disease were also more likely to undergo BLMast. Conclusions: VUS genetic testing results may significantly influence lumpectomy-eligible patient decision-making. In an era of expanded genetic testing access, the present analysis informs the implementation of robust but accessible genetic counseling education initiatives in breast surgical oncology to decrease unnecessary mastectomies in patients with VUS. [Table: see text]
Reasons for unmet care needs in older adults with cancer: Analyses from the 2015–2019 National Health and Aging Trends Study.
Authors: Wang Ying , Williams AnnaLynn , Jensen-Battaglia Marielle , Loh Kah Poh , Norton Sally , Seplaki Christopher 
Published: June 2024

11112 Background: Despite extensive research on unmet care needs in older adults (ages ≥65) with cancer, few studies explore the reasons for unmet care needs, knowledge of which can inform future interventions. We aimed to identity reasons for unmet care needs in older adults with cancer and associated factors. Methods: Our analyses included community-dwelling older adults with cancer from the 2015–2019 National Health and Aging Trends Study (NHATS). NHATS captures unmet care needs in 12 activities from three domains: activities of daily living (ADL), instrumental ADL (IADL), and mobility. We separately evaluated two categories of reasons for unmet care needs: “difficulty performing activities independently” (for participants without a caregiver), and “caregivers’ inability to help” (for those receiving caregiver assistance). Personal characteristics included demographic (gender, age, marital status, race, ethnicity, educational level), clinical (cancer type, years since cancer diagnosis), and health variables (physical function, nutritional status, cognition, psychological status). We built logistic models to assess characteristics associated with unmet care needs, adjusting for NHATS year and cancer type. In exploratory analyses, we further evaluated associations of years since cancer diagnosis with unmet care needs. All models were built separately for participants with and without a caregiver. Results: Our analysis included 1829 participants. In 2015, participants had a mean age of 81 years; more than half were female (55%), White (79%), non-Hispanic (96%), had impaired physical function (92%), and received caregiver assistance (51%). From 2015 to 2019, 29% to 32% participants without a caregiver reported any unmet care needs due to difficulty with performing the activity independently, with toileting (45-53%) and managing medications (27-31%) being the most prevalent. Between 18% and 20% participants with a caregiver reported any unmet care needs due to caregivers’ inability to help, with toileting (26-44%) and going around inside home (20-29%) being the most prevalent. Hispanic ethnicity, being separated/divorced, living alone or with non-spouses, and worse health status were independently associated with unmet care needs due to either reason. Compared to pre-diagnosis, being 1-2, [odds ratio (OR) 1.7], 3-4 (OR 1.8) and 5+ (OR 2.2) years from cancer diagnosis was significantly associated with higher odds of unmet care needs among those without a caregiver, but not those with a caregiver. Conclusions: Unmet care needs due to difficulty performing activities independently are common among older adults with cancer. Caregivers generally meet care recipients’ needs in IADLs, but may face challenges in toileting and mobility needs. Tailored interventions addressing specific reasons for unmet needs are needed, particularly for those at greater risk.