bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cognitive Remediation and Emotion Skills Training for Anorexia Nervosa: An Observational Study Using Neuropsychological Outcomes
Authors: Davies Helen , Fox John , Naumann Ulrike , Treasure Janet , Schmidt Ulrike , Tchanturia Kate 
Published: March 2012

AbstractObjectiveThis study aims to evaluate a novel and brief skills‐based therapy for in‐patients with anorexia nervosa, which addressed ‘cold’ and ‘hot’ cognition.MethodEighty one adults with anorexia nervosa were recruited from two eating disorder in‐patient units. In one unit, patients received 10 sessions of cognitive remediation and emotion skills training (CREST) plus treatment as usual. In the other, patients received treatment as usual only. Primary outcomes were body mass index and neuropsychological performance scores.ResultsBoth groups improved significantly in body mass index and cognitive flexibility. The CREST group also improved on central coherence. Neither group improved significantly on emotion‐processing tasks, although the CREST group did show a larger magnitude of change.ConclusionImprovement in ‘cold’ cognition was achieved in a short period, whereas emotion‐processing difficulties might take longer and more therapeutic work to change. Given that effect sizes in the CREST group were larger for the emotion‐processing tasks, improved power may benefit future studies. Copyright © 2012 John Wiley & Sons, Ltd and Eating Disorders Association.
Oral and oropharyngeal squamous cell carcinoma in young patients: The Netherlands Cancer Institute experience
Authors: van Monsjou Hester S. , Lopez–Yurda Marta I. , Hauptmann Michael , van den Brekel Michiel W. M. , Balm Alfons J. M. , Wreesmann Volkert B. 
Published: March 2012

AbstractBackgroundHead and neck squamous cell carcinoma (HNSCC) mainly affects patients between the fifth and seventh decade of life but is increasingly seen in young patients (<40 years old). Controversy exists in the literature regarding outcomes for younger patients with HNSCC.MethodsA retrospective cohort analysis was performed comparing survival of 54 early‐onset (<40 years) and 1708 older patients with oral and oropharyngeal squamous cell carcinomas (SCC) treated at The Netherlands Cancer Institute between 1977 and 2008. Survival analysis was performed using univariable and multivariable weighted Cox proportional hazards regression. The primary endpoint for the survival analysis was disease‐specific survival (DSS).ResultsThere was no difference in DSS between patients who were 40 years or younger and those older than 40 years (p = .878), although young patients had significantly better overall survival (OS).ConclusionIn this series, patients younger than 40 years with oral and oropharyngeal SCC showed no significant difference in DSS compared with patients older than 40 years, even when adjusted for tobacco and alcohol consumption. © 2012 Wiley Periodicals, Inc. Head Neck, 2013
Thyroid disease associated with cowden syndrome: A meta‐analysis
Authors: Hall Joseph E. , Abdollahian Davood J. , Sinard Robert J. 
Published: March 2012

AbstractBackgroundWe investigated the pathology and surgical management of thyroid disease in patients with Cowden syndrome (CS).MethodsA query of the PubMed database between 2001 and January 2010 was performed using the terms “cowden syndrome OR cowden's syndrome OR cowden disease OR cowden's disease.” Original articles, reviews, case reports, and case series were included. Articles were excluded if they were not written in English, did not present case/cases of CS, or did not include patient information to qualify for a diagnosis of CS. Ninety‐five articles met the inclusion and exclusion criteria. A total of 181 cases were analyzed.ResultsOf the 181 patients, 99 female (54.7%) and 77 male patients (42.5%) had sex reported. The age at presentation ranged from 3 days to 78 years. Ninety‐six patients (96/181, 53.0%) were reported to have thyroid disease. Surgical management of thyroid disease was performed in 80.2% (77/96) of patients with thyroid disease, with total thyroidectomy being the most common operation reported (23/77, 29.9%). Thyroid pathology reported with CS patients included goiter (39/96, 40.6%), adenoma (24/96, 25%), unknown/unspecified pathology (8/96, 8.3%), follicular carcinoma (7/96, 7.3%), thyroiditis (7/96, 7.3%), papillary carcinoma (6/96, 6.3%), cancer (unknown type) (3/96, 3.1%), medullary carcinoma (1/96, 1%), and hyperthyroidism (1/96, 1%).ConclusionCareful monitoring of thyroid disease in CS patients is imperative. © 2012 Wiley Periodicals, Inc. Head Neck, 2013
Improving SEM Inspection Performance in Semiconductor Manufacturing Industry
Authors: Lin Chih‐Long , Chen Fu‐Sheng , Twu Li‐Jen , Wang Mao‐Jiun J. 
Published: March 2012

AbstractScanning electron microscope (SEM) station is one of the major quality control tasks in wafer manufacturing process. During the process of examining defects on a screen for a certain period of time, SEM inspectors frequently complain about visual fatigue problems. The purpose of the study was to evaluate the effect of wafer‐coating condition (noncoating treatment and gold‐coating treatment) and liquid crystal display (LCD) monitor size (14‐inch and 19‐inch monitor) from the aspects of objective visual fatigue measures (NPA and CFF), subjective eye fatigue rating, and inspection performance. Twelve SEM inspectors participated in this experiment. The results indicated that the treatment of gold‐coating wafer showed significant difference on reducing objective visual fatigue in NPA and CFF change. Using a 19‐inch LCD monitor also demonstrated the effect on reducing eye fatigue as well as improving inspection performance. The improvement of using a gold‐coating treatment wafer and a 19‐inch LCD monitor to reduce SEM inspectors' visual fatigue and to increase inspection performance is thus recommended. © 2012 Wiley Periodicals, Inc.
Prevalence and associated risk factors of low‐back pain in textile fishing net manufacturing
Authors: Keawduangdee Petcharat , Puntumetakul Rungthip , Chatchawan Uraiwon , Kaber David , Siritaratiwat Wantana 
Published: March 2012

AbstractThis study examined the 7‐day prevalence of low‐back pain (LBP; i.e., pain within the preceding week of the survey) and identified associated factors, including working posture, for a population of fishing net assembly workers. LBP is a serious problem in manual work with high prevalence and affects worker absenteeism. A cross‐sectional survey study was conducted among textile fish net industrial workers using a structured questionnaire (hand delivered by researchers and independently completed by workers). The 7‐day prevalence of LBP in this study was 68.6% (95% confidence interval [CI]: 65 to 72%). Work factors significantly related to LBP included prolonged standing and walking. Workers 35 years old or greater were significantly more likely to experience LBP within the past 7 days preceding the survey than were those 34 years old or less (adjusted odds ratio [ORadj] = 4.9; 95% CI: 2.4 to 10.3; p = .0001). Other significant factors associated with LBP included posture position, specifically stooping (ORadj = 1.6; 95% CI: 1.0 to 2.3; p = .033), lifting (ORadj = 1.6; 95% CI: 1.1 to 2.4; p = .025), and high concentration jobs (ORadj = 1.9; 95% CI: 1.3 to 2.7; p = .001), respectively. LBP among textile fish net workers is a serious problem meriting ergonomic evaluation and design of control measures for reducing worker exposure to risk factors. Work characteristics were more significantly associated with LBP than were individual characteristics. Factories need to consider adjusting work conditions to prevent worker low‐back injuries. © 2012 Wiley Periodicals, Inc.
Integrating novel signaling pathways involved in erythropoiesis
Authors: Ingley Evan 
Published: March 2012

AbstractMany extrinsic and intrinsic factors control the development of red blood cells from committed progenitors, with the Erythropoietin‐receptor (Epo‐R) signaling network being the primary controlling molecular hub. Although much is understood about erythroid signaling pathways, new and intriguing factors that influence different aspects of erythroid cell development are still being uncovered. New extrinsic effectors include hypoxia and polymeric IgA1 (pIgA1), and new Epo‐R signaling pathway components include Lyn/Cbp and Lyn/Liar. Hypoxia directly activates committed erythroid progenitors to expand, whereas pIgA1 activates the Akt and MAP‐Kinase (MAPK) pathways through transferrin receptors on more mature erythroid cells. The Lyn/Cbp pathway controls the activity and protein levels of Lyn through recruitment of Csk and SOCS1, as well as feeding into the control of other pathways mediated by recruitment of ras‐GAP, PI3‐kinase, PLCγ, Fes, and EBP50. Nuclear/cytoplasmic shuttling of Lyn and other signaling molecules is influenced by Liar and results in regulation of their intersecting signaling pathways. The challenge of future research is to flesh out the details of these new signaling regulators/networks and integrate their influences during the different stages of erythropoiesis. 2012 IUBMB IUBMB Life, 2012
Serum response factor regulates bone formation via IGF-1 and Runx2 signals
Authors: Chen Jianfeng , Yuan Kaiyu , Mao Xia , Miano Joseph M , Wu Hui , Chen Yabing 
Published: March 2012

Abstract
Serum response factor (SRF) plays vital roles in numerous cellular processes; however, the physiological function of SRF in skeletal tissue remains unknown. In several organ systems, SRF regulates the expression of insulin-like growth factor-1 (IGF-1), which is crucial for normal development of mineralized skeleton and bone remodeling throughout life. Here, we show that conditional deletion of SRF in osteoblasts by osteocalcin-Cre generated viable mice with normal body size and body weight. Compared with normal siblings, osteoblast-specific SRF-deficient adult mice exhibited a marked decrease in bone mineral density and bone formation rate. Deletion of SRF in primary mouse calvarial osteoblasts reduced cell differentiation and mineralization in vitro. This was accompanied by a decrease in IGF-1 expression and secretion. Addition of IGF-1 in the culture media enhanced osteoblast differentiation in control cells and partially restored the mineralization defect of SRF-deficient cells, supporting an important role of SRF in regulating IGF-1 and IGF-1–mediated osteoblast differentiation. IGF-1–induced Akt activation was inhibited in SRF-deficient calvarial cells and enhanced in the SRF overexpressed cells. In addition, SRF deficiency decreased the transcriptional activity of Runx2, the key transcription factor for osteogenesis. Overexpression of SRF induced Runx2 transactivity in control cells and restored Runx2 transactivity in the SRF-deficient cells. Taken together, we conclude that SRF is important for IGF-1–induced osteoblast differentiation and mineralization via regulating IGF-1 expression and Runx2 transactivity. © 2012 American Society for Bone and Mineral Research.
Absence of sclerostin adversely affects B-cell survival
Authors: Cain Corey J , Rueda Randell , McLelland Bryce , Collette Nicole M , Loots Gabriela G , Manilay Jennifer O 
Published: March 2012

Abstract
Increased osteoblast activity in sclerostin-knockout (Sost−/−) mice results in generalized hyperostosis and bones with small bone marrow cavities resulting from hyperactive mineralizing osteoblast populations. Hematopoietic cell fate decisions are dependent on their local microenvironment, which contains osteoblast and stromal cell populations that support both hematopoietic stem cell quiescence and facilitate B-cell development. In this study, we investigated whether high bone mass environments affect B-cell development via the utilization of Sost−/− mice, a model of sclerosteosis. We found the bone marrow of Sost−/− mice to be specifically depleted of B cells because of elevated apoptosis at all B-cell developmental stages. In contrast, B-cell function in the spleen was normal. Sost expression analysis confirmed that Sost is primarily expressed in osteocytes and is not expressed in any hematopoietic lineage, which indicated that the B-cell defects in Sost−/− mice are non-cell autonomous, and this was confirmed by transplantation of wild-type (WT) bone marrow into lethally irradiated Sost−/− recipients. WT→Sost−/− chimeras displayed a reduction in B cells, whereas reciprocal Sost−/−→WT chimeras did not, supporting the idea that the Sost−/− bone environment cannot fully support normal B-cell development. Expression of the pre-B-cell growth stimulating factor, Cxcl12, was significantly lower in bone marrow stromal cells of Sost−/− mice, whereas the Wnt target genes Lef-1 and Ccnd1 remained unchanged in B cells. Taken together, these results demonstrate a novel role for Sost in the regulation of bone marrow environments that support B cells. © 2012 American Society for Bone and Mineral Research.
Transcript characteristic of myostatin in sheep fibroblasts
Authors: Lu Jian , Ren Hangxing , Sheng Xihui , Zhang Xiaoning , Li Shangang , Zhao Fuping , Zhou Xinlei , Zhang Li , Wei Caihong , Ding Jiatong , Li Bichun , Du Lixin 
Published: March 2012

AbstractMyostatin, a secreted growth factor highly expressed in skeletal muscle, negatively regulates skeletal muscle growth and differentiation. Recently, myostatin is emerged as a potential target for anti‐atrophy and anti‐fibrotic therapies. Therefore, to investigate the regulation of myostatin in sheep adult fibroblasts, we used the RNA interference mediated by lentiviral vector to gene silence myostatin. Simultaneously, we also had constructed the sheep myostatin overexpression vector to further explore the function of myostatin in fibroblasts. The results here demonstrated that the lentiviral vector could significantly reduce myostatin gene both at mRNA and protein level by 71% and 67%, respectively (P < 0.01). Inhibition of myostatin also resulted in a remarkable increase of activin receptor 2B (ACV2B), p21, PPARγ, leptin, C/EBPβ, and MEF2A expression, and a decrease of Akt1, CDK2, MEF2C, and Myf5 expression. Ectopic myostatin mRNA and protein were also present in the fibroblasts transfection. Furthermore, we observed that overexpression of myostatin contributed to an increase of Akt1, CDK2, Myf5 and PPARγ, and a decrease of p21, C/EBPα and leptin at the transcript level. These results suggested that myostatin positively regulated Akt1, CDK2, Myf5, leptin, and C/EBPα, but negatively regulated p21 mRNA expression in adult fibroblasts, and it also expanded our understanding of the regulation mechanism of myostatin. Moreover, the lentiviral system inactivated myostatin gene in fibroblasts would be used to generate transgenic sheep and to ameliorate muscle fibrosis and atrophy by gene therapy in the future. J. Cell. Biochem. 113: 2652–2660, 2012. © 2012 Wiley Periodicals, Inc.
Interferon regulatory factor‐1 as a positive regulator for high glucose‐induced proliferation of vascular smooth muscle cells
Authors: Yu Sun , Xi Zhang , Hai‐Yan Chen , Ya‐Li Chi , Shao‐Hu Xiong , Chuan‐Sen Zhang , Xiang‐Qun Yang , Jin‐Ping Guo , Hai‐Yan Lin , Lei Dong 
Published: March 2012

AbstractHigh glucose‐induced proliferation of vascular smooth muscle cells (VSMCs) plays an important role in the development of diabetic vascular diseases. However, molecular mediators responding for the proliferation of VSMCs remain to be determined. In this study, VSMCs were isolated from the rat thoracic aorta, and two cell models with Irf‐1 knockdown and overexpression were established by transfecting cells with pGCsi‐FU‐Irf‐1 and pGC‐FU‐Irf‐1, respectively. Subsequently, high glucose was added to cells to induce proliferation. Proliferation assays were performed to see whether Irf‐1 was involved in high glucose‐induced proliferation of VSMCs. In addition, the expression of Irf‐1 was detected in VSMCs stimulated with high glucose and the thoracic aorta of diabetic rats to confirm the relationship between Irf‐1 expression and the proliferation of hyperglycemia‐dependent VSMCs. The results showed that Irf‐1 expression was significantly higher in the thoracic aorta of diabetic rats and VSMCs stimulated with high glucose than that in nondiabetic rats and untreated cells. Overexpression of Irf‐1 accelerated the proliferation of VSMCs, and down‐regulation of Irf‐1 expression significantly depressed the proliferative ability of VSMCs under high‐glucose conditions, indicating that Irf‐1 was a positive regulator for high glucose‐induced proliferation of VSMCs. It could be presumed that Irf‐1 is associated with the accelerated proliferation of VSMCs in diabetic vascular diseases and may prove to be a potential target gene for disease treatment. J. Cell. Biochem. 113: 2671–2678, 2012. © 2012 Wiley Periodicals, Inc.
Assessment of intermolecular interactions at three sites of the arylalkyne in phenylacetylene‐containing lithium‐bonded complexes: Ab initio and QTAIM studies
Authors: Zeng Yanli , Zhu Min , Li Xiaoyan , Zheng Shijun , Meng Lingpeng 
Published: March 2012

AbstractThe intermolecular interactions existing at three different sites between phenylacetylene and LiX (X = OH, NH2, F, Cl, Br, CN, NC) have been investigated by means of second‐order Møller−Plesset perturbation theory (MP2) calculations and quantum theory of “atoms in molecules” (QTAIM) studies. At each site, the lithium‐bonding interactions with electron‐withdrawing groups (F, Cl, Br, CN, NC) were found to be stronger than those with electron‐donating groups (OH and NH2). Molecular graphs of C6H5CCH···LiF and πC6H5CCH···LiF show the same connectional positions, and the electron densities at the lithium bond critical points (BCPs) of the πC6H5CCH···LiF complexes are distinctly higher than those of the σC6H5CCH···LiF complexes, indicating that the intermolecular interactions in the C6H5CCH···LiX complexes can be mainly attributed to the π‐type interaction. QTAIM studies have shown that these lithium‐bond interactions display the characteristics of “closed‐shell” noncovalent interactions, and the molecular formation density difference indicates that electron transfer plays an important role in the formation of the lithium bond. For each site, linear relationships have been found between the topological properties at the BCP (the electron density ρb, its Laplacian ∇2ρb, and the eigenvalue λ3of the Hessian matrix) and the lithium bond lengthd(Li‐bond). The shorter the lithium bond lengthd(Li‐bond), the larger ρb, and the stronger the π···Li bond. The shorterd(Li‐bond), the larger ∇2ρb, and the greater the electrostatic character of the π···Li bond. © 2012 Wiley Periodicals, Inc.
Assessment of ab initio MP2 and density functionals for characterizing the potential energy profiles of the SN2 reactions at N center
Authors: Yu Feng 
Published: March 2012

AbstractThe potential energy profiles of five selected bimolecular nucleophilic substitution (SN2) reactions at nitrogen (N) center have been reinvestigated with the CCSD(T), G3[MP2,CCSD(T)], MP2, and some density functional methods. The basis sets of 6‐31+G(d,p) and 6‐311+G(3d,2p) are used for the MP2 and density functional calculations. Taking the relative energies at the CCSD(T)/CBS level of theory as benchmarks, we recommend the MP2, B97‐K, B2K‐PLYP, BMK, ωB97X‐D, M06‐2X, M05‐2X, CAM‐B3LYP, M08‐SO, and ωB97X methods to generally characterize the potential energy profiles for the SN2 reactions at N center. Furthermore, these recommended methods with the relatively small 6‐31+G(d,p) basis set may also be used to perform direct classical trajectory simulations to uncover the dynamic behaviors of the SN2 reactions at N center. © 2012 Wiley Periodicals, Inc.
Droughts and their social perception in the mass media (southern Spain)
Authors: Ruiz Sinoga Jose Damian , León Gross Teodoro 
Published: March 2012

AbstractIn the Mediterranean environment, drought is one of the extreme phenomena that has most direct consequences and complexity. It also has a direct social impact through the mass media, whose analysis, typology and characterization should be a priority in strategies to plan and mitigate effects. The appearance of droughts is slow, their occurrence is often not recognized until human activity and the environment have already been significantly affected, and drought effects persist for a long time after the drought has ended. The spatial distribution of droughts is highly complex, and significant variation in drought conditions is common between different locations. This makes it difficult to identify similar regions, especially in areas of climate transition, where the atmospheric influences are complex. This is the situation in the Iberian Peninsula (particularly the south of the peninsula), which straddles both temperate and sub‐tropical climates and in which precipitation is highly variable and spatial variability is substantial. In this study, we analysed rainfall anomalies (Standardized Precipitation Index, SPI) over the last 50 years at four representative meteorological stations in southern Spain, two on the coast (Málaga and Algarrobo) and two at the headwaters of river basins regulated by dams (Antequera and Periana). The aims of the study were to (1) analyse the types of drought, and their frequency and intensity and (2) establish the dynamics and evolution of the social perception of droughts in the context of global change, brought about by the communications media. The results showed the SPI was a useful tool for identifying dry anomalies that may feature in our field of study of meteorological and hydrological drought, depending on its duration. Meteorological drought impact on the eco‐geomorphological system is common and has had a particular development since the 1980s. Hydrological droughts are those that have had the greatest effect on water reserves, particularly when they occur in the headwaters of the watershed covered by reservoirs. Their importance has increased since the 1980s. Determination of drought periods and its impact mass media could have extraordinary relevance as a mechanism to establish the levels of awareness on sustainable use of resources. For future research, other socioeconomic and demographic variables should be considered to know the link between drought and water deficit. Copyright © 2012 Royal Meteorological Society
The effect of solution temperature and pH on corrosion performance and morphology of nanoceramic‐based conversion thin film
Authors: Mohammadloo H. Eivaz , Sarabi A. A. , Alvani A. A. Sabbagh , Salimi R. , Sameie H. 
Published: March 2012

AbstractIn the present study, a nanoceramic hexafluorozirconic acid was used as an eco‐friendly conversion coating, which is free of the conventional phosphate salts. The effect of practical parameters on morphology and corrosion resistance of the coating was studied. Anti‐corrosion behavior of the nanoceramic‐based conversion coating on cold rolled steel substrates was evaluated at different solution pH and temperatures, utilizing the electrochemical impedance spectroscopy and direct current polarization. Moreover, the morphology of thin films was studied using field emission scanning electron microscopy (FE‐SEM). The results revealed that the conversion thin films formed at a dipping temperature of 20 °C and pH 4.5 showed best anti‐corrosion performance. SEM images indicated that increasing solution temperature resulted in micro‐cracks creation and lack of consistency on the surface of the conversion coating. Moreover, the morphological structure changed with increasing pH value.