bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of Right Ventricular Pacing Sites on Exercise Capacity during Ventricular Rate Regularization in Patients with Permanent Atrial Fibrillation
Authors: TSE HUNG‐FAT , SIU CHUNG‐WAH , LAU CHU‐PAK 
Published: October 2009

Background:

The deleterious effects of right ventricular apical (RVA) pacing may offset the potential benefit of ventricular rate (VR) regularization and rate adaptation during an exercise in patient's atrial fibrillation (AF).
Methods:

We studied 30 patients with permanent AF and symptomatic bradycardia who receive pacemaker implantation with RVA (n = 15) or right ventricular septal (RVS, n = 15) pacing. All the patients underwent an acute cardiopulmonary exercise testing using VVI‐mode (VVI‐OFF) and VVI‐mode with VR regularization (VRR) algorithm on (VVI‐ON).
Results:

There were no significant differences in the baseline characteristics between the two groups, except pacing QRS duration was significantly shorter during RVS pacing than RVA pacing (138.9 ± 5 vs 158.4 ± 6.1 ms, P = 0.035). Overall, VVI‐ON mode increased the peak exercise VR, exercise time, metabolic equivalents (METs), and peak oxygen consumption (VO2max), and decreased the VR variability compared with VVI‐OFF mode during exercise (P < 0.05), suggesting that VRR pacing improved exercise capacity during exercise. However, further analysis on the impact of VRR pacing with different pacing sites revealed that only patients with RVS pacing but not patients with RVA pacing had significant increased exercise time, METs, and VO2max during VVI‐ON compared with VVI‐OFF, despite similar changes in peaked exercise VR and VR variability.
Conclusion:

In patients with permanent AF, VRR pacing at RVS, but not at RVA, improved exercise capacity during exercise.
Enhanced solute removal with intermittent, in‐center, 8‐hour nocturnal hemodialysis
Authors: TROIDLE Laura , FINKELSTEIN Fredric , HOTCHKISS Mark , LEYPOLDT John Ken 
Published: October 2009

AbstractAdvances in the dialysis technique and increasing urea Kt/V have not improved outcomes for end‐stage renal disease patients maintained on hemodialysis (HD) therapy. Attention has, thus, focused on enhancing solute removal via prolonged HD sessions. A reduction in the serum levels of phosphorus and β‐2‐microglobulin (B2M) with longer HD treatments has been linked to improved patient outcomes. We have shown that serum phosphorus levels are significantly lowered in patients maintained on thrice‐weekly, in‐center, 8‐hour nocturnal HD performed at a blood flow rate of 400 mL/min. The kinetics of this modality were examined. A total of 8 patients participated in the study (age 45±7 years). Serum creatinine levels decreased from 9.2±1.9 to 3.0±1.0 mg/dL at 8 hours while serum phosphorus decreased from 5.7±1.9 to 2.5±0.7 mg/dL at 8 hours. The initial decrease from predialysis values to 1 hour after the start of HD was significant for both creatinine (P<0.0001) and phosphorus (P<0.001). Serum B2M decreased from 26.8±5.5 mg/L predialysis to 14.9±7.0 mg/L at 8 hours (P<0.01). Dialysate‐side clearances of phosphorus and creatinine were 136±13  and 143±27 cm3/min, respectively. Phosphorus clearances were steadily maintained during the 8‐hour session. A total of 904±292 mg of phosphorus was removed during the 8‐hour treatment, with 501±174 mg (55%) removed during the first 4 hours and the remaining 45% continuously removed during the latter one‐half of the session. The overall calculated B2M clearance was 55.1±40.3 cm3/min using the immediate post‐B2M value and 28.4±34.2 mg/L using the 30‐minute postdialysis value for the calculation. Serum levels of phosphorus and B2M decrease dramatically during an 8‐hour session. Future studies are necessary to determine whether the enhanced solute removal with longer HD sessions translates into an improved outcome for HD patients.
Encapsulating peritoneal sclerosis: Importance to the hemodialysis practitioner
Authors: PERL Jeffrey , BARGMAN Joanne M. , CHAN Christopher T. 
Published: October 2009

AbstractEncapsulating peritoneal sclerosis (EPS) is a rare but devastating complication of long‐term peritoneal dialysis (PD) therapy. Encapsulating peritoneal sclerosis is characterized by peritoneal membrane inflammation, followed by progressive peritoneal membrane fibrosis and intestinal encapsulation. Clinical manifestations include ascites as well as intermittent and recurrent small bowel obstruction. The prognosis of EPS is poor. The exact cause of EPS remains unknown. While the risk factors for EPS are not well elucidated, EPS is seen with increased frequency after an increased duration of PD therapy. In more than half the patients who develop EPS, the diagnosis is made after transfer to hemodialysis (HD). It is important for the HD practitioner to initiate surveillance in any patient at risk for EPS while maintaining a heightened index of suspicion for EPS in an HD patient with gastrointestinal symptoms and a history of previous PD therapy. Early diagnosis and prompt initiation of treatment is essential. Early in the course of EPS, immunosuppressive therapy remains the mainstay of treatment. Ultimately, parenteral nutritional support may be required along with surgical therapy to relieve intestinal obstruction. We report a case of EPS in an HD patient at our center highlighting the incidence, risk factors, and treatment strategies in the context of available evidence.
Frequency and clinical correlates of adult separation anxiety in a sample of 508 outpatients with mood and anxiety disorders
Authors: Pini S. , Abelli M. , Shear K. M. , Cardini A. , Lari L. , Gesi C. , Muti M. , Calugi S. , Galderisi S. , Troisi A. , Bertolino A. , Cassano G. B. 
Published: October 2009

Pini S, Abelli M, Shear KM, Cardini A, Lari L, Gesi C, Muti M, Calugi S, Galderisi S, Troisi A, Bertolino A, Cassano GB. Frequency and clinical correlates of adult separation anxiety in a sample of 508 outpatients with mood and anxiety disorders.Objective:  To evaluate the frequency and clinical correlates of adult separation anxiety disorder in a large cohort of patients with mood and anxiety disorders.Method:  Overall, 508 outpatients with anxiety and mood disorders were assessed by the structured clinical interview for diagnostic and statistical manual (IV edition) axis I disorders for principal diagnosis and comorbidity and by other appropriate instruments for separation anxiety into adulthood or childhood.Results:  Overall, 105 subjects (20.7%) were assessed as having adult separation anxiety disorder without a history of childhood separation anxiety and 110 (21.7%) had adult separation anxiety disorder with a history of childhood separation anxiety. Adult separation anxiety was associated with severe role impairment in work and social relationships after controlling for potential confounding effect of anxiety comorbidity.Conclusion:  Adult separation anxiety disorder is likely to be much more common in adults than previously recognized. Research is needed to better understand the relationships of this condition with other co‐occurring affective disorders.
Risk factors for incident mild cognitive impairment – results from the German Study on Ageing, Cognition and Dementia in Primary Care Patients (AgeCoDe)
Authors: Luck T. , Riedel‐Heller S. G. , Luppa M. , Wiese B. , Wollny A. , Wagner M. , Bickel H. , Weyerer S. , Pentzek M. , Haller F. , Moesch E. , Werle J. , Eisele M. , Maier W. , Van Den Bussche H. , Kaduszkiewicz H. ,   for the AgeCoDe Study Group
Published: October 2009

Luck T, Riedel‐Heller SG, Luppa M, Wiese B, Wollny A, Wagner M, Bickel H, Weyerer S, Pentzek M, Haller F, Moesch E, Werle J, Eisele M, Maier W, van den Bussche H, Kaduszkiewicz H for the AgeCoDe Study Group. Risk factors for incident mild cognitive impairment – results from the German Study on Ageing, Cognition and Dementia in Primary Care Patients (AgeCoDe).Objectives:  To provide age‐ and gender‐specific incidence rates of MCI among elderly general practitioner (GP) patients (75+ years) and to identify risk factors for incident MCI.Method:  Data were derived from the longitudinal German Study on Ageing, Cognition and Dementia in Primary Care Patients (AgeCoDe). Incidence was calculated according to the ‘person‐years‐at‐risk’ method. Risk factors were analysed using multivariate logistic regression models.Results:  During the 3‐year follow‐up period, 350 (15.0%) of the 2331 patients whose data were included in the calculation of incidence developed MCI [person‐years (PY) = 6198.20]. The overall incidence of MCI was 56.5 (95% confidence interval = 50.7–62.7) per 1000 PY. Older age, vascular diseases, the apoE ε4 allele and subjective memory complaints were identified as significant risk factors for future MCI.Conclusion:  Mild cognitive impairment is frequent in older GP patients. Subjective memory complaints predict incident MCI. Especially vascular risk factors provide the opportunity of preventive approaches.
Illicit substance use and its correlates in first episode psychosis
Authors: Mazzoncini R. , Donoghue K. , Hart J. , Morgan C. , Doody G. A. , Dazzan P. , Jones P. B. , Morgan K. , Murray R. M. , Fearon P. 
Published: October 2009

Mazzoncini R, Donoghue K, Hart J, Morgan C, Doody GA, Dazzan P, Jones PB, Morgan K, Murray RM, Fearon P. Illicit substance use and its correlates in first episode psychosis.Objective:  To determine if substance use (particularly cannabis) is more frequent among first episode psychosis patients and associated with a more problematic clinical presentation.Method:  All first episode psychosis (FEP) patients presenting to secondary services were recruited from London and Nottingham, over 2 years, in the Aetiology and Ethnicity of Schizophrenia and Other Psychoses study broad framework. Clinical and sociodemographic variables were assessed using a set of standardized instruments. A schedule was created to retrospectively collate substance use data from patients, relatives and clinicians.Results:  Five hundred and eleven FEP were identified. They used three to five times more substances than general population. Substance use was associated with poorer social adjustment and a more acute mode of onset. Cannabis use did not affect social adjustment, but was associated with a more acute mode of onset.Conclusion:  Cannabis has a different impact on FEP than other substances. Large epidemiological studies are needed to disentangle cannabis effect.
Recent time trends in levels of self‐reported anxiety, mental health service use and suicidal behaviour in Stockholm
Authors: Kosidou K. , Magnusson C. , Mittendorfer‐Rutz E. , Hallqvist J. , Hellner Gumpert C. , Idrizbegovic S. , Dal H. , Dalman C. 
Published: October 2009

Kosidou K, Magnusson C, Mittendorfer‐Rutz E, Hallqvist J, Gumpert CH, Idrizbegovic S, Dal H, Dalman C. Recent time trends in levels of self‐reported anxiety, mental health service use and suicidal behaviour in Stockholm.Objective: To investigate recent time trends in several indicators of mental ill‐health and the patterning of these indicators between genders and younger vs. older individuals in Stockholm County.Method: Several indicators were used; self‐reported anxiety from the Swedish Survey of Living Conditions, information on psychiatric in‐patient and out‐patient care, attempted and completed suicides from national and regional registers. Gender‐ and age‐specific trends were compared for the time period of 1997–2006.Results: Self‐reported anxiety and psychiatric service use increased among young individuals of both genders, while attempted suicides increased only among young women. By contrast, these indicators decreased or remained stable in the older age group from year 2001 and onwards.Conclusion: Our data indicate a rising, and highly prevalent, mental ill‐health among the young in Stockholm County, a region representative of urbanized, secular Western societies.
Effects of relaxin on collagen type I released by stretched human periodontal ligament cells
Authors: Takano M , Yamaguchi M , Nakajima R , Fujita S , Kojima T , Kasai K 
Published: October 2009

Structured AbstractAuthors –  Takano M, Yamaguchi M, Nakajima R, Fujita S, Kojima T, Kasai KObjectives –  Relapse of teeth that have moved during orthodontic treatment is a major clinical issue with respect to the goals of successful treatment. Such relapse is a physiologic response of the supporting tissues to application of force, and is mainly attributed to occlusal instability and increased mechanical tension exerted by the periodontal ligament (PDL). Relaxin, a member of the insulin/relaxin family of structurally related hormones, has an influence on many physiologic processes, such as collagen turnover, angiogenesis, and antifibrosis. Therefore, relaxin may also affect orthodontic tooth movement through alterations of the PDL, though little is known regarding the relationship between relaxin and stretched human PDL (hPDL) cells. In the present study, we investigated the effects of relaxin on the expression of collagen type I (Col‐I) and matrix metalloproteinase 1 (MMP‐1) in stretched hPDL cells in vitro.Materials and Methods –  The release and gene expression of Col‐I, as well as those of MMP‐1 in stretched hPDL cells treated with relaxin were investigated using enzyme‐linked immunosorbent assay and real‐time PCR methods.Results –  Relaxin decreased the release and gene expression of Col‐I, and increased those of MMP‐1 by stretched hPDL cells in a magnitude‐dependent manner.Conclusion –  Our results indicate that relaxin modulates collagen metabolism in stretched hPDL cells via the release and expression of Col‐I and MMP‐1. This hormone may be useful to prevent orthodontic relapse following orthodontic treatment.
Low‐energy laser irradiation accelerates the velocity of tooth movement via stimulation of the alveolar bone remodeling
Authors: Yoshida T , Yamaguchi M , Utsunomiya T , Kato M , Arai Y , Kaneda T , Yamamoto H , Kasai K 
Published: October 2009

Structured AbstractAuthors –  Yoshida T, Yamaguchi M, Utsunomiya T, Kato M, Arai Y, Kaneda T, Yamamoto H, Kasai KIntroduction –  Previously, the authors have reported the acceleration of tooth movement and osteoclastogenesis on the pressure site in an experimental tooth movement model by low‐energy laser irradiation (LELI), which stimulated the RANK/RANKL system and c‐fms/macrophage colony‐stimulating factor system. However, the effect of LELI on osteogenesis on the tension site is not known clearly. Moreover, the temporal changes in alveolar bone during tooth movement have not been investigated as yet. Therefore, the present study was designed to examine the effects of LELI on alveolar bone remodeling during experimental tooth movement, and observe the temporal bone mineral density (BMD) using micro‐computed tomography (μCT).Materials and methods –  To induce experimental tooth movement in rats, 10 g force was applied to the upper right first molar with Nickel titanium closed‐coil. Next, a gallium‐aluminum‐arsenide (Ga‐Al‐As) diode laser was used to irradiate the area around the moved tooth, and BMD and the amount of tooth movement were measured by μCT scanning for 21 days. Histopathological examination was also performed.Results –  The amount of tooth movement in the LELI group was significantly greater than in the non‐irradiation group by the end of the experimental period. Further, compared with the non‐irradiation group, the fall of BMD was less in the LELI group.Conclusion –  These findings suggest that LELI accelerates the velocity of tooth movement via stimulation of the alveolar bone remodeling.
Comparison of cortical bone thickness and root proximity at maxillary and mandibular interradicular sites for orthodontic mini‐implant placement
Authors: Lim JE , Lee SJ , Kim YJ , Lim WH , Chun YS 
Published: October 2009

Structured AbstractAuthors –  Lim JE, Lee SJ, Kim YJ, Lim WH, Chun YSObjectives –  To compare maxillary and mandibular cortical bone thickness and rootic proximity for optimal mini‐implant placement.Setting and Sample Population –  CT images from 14 men and 14 women were used to evaluate buccal interradicular cortical bone thickness and root proximity from mesial of the central incisor to the 2nd molar. Cortical bone thickness was measured at 0°, 15°, 30°, and 45° angles relative to the root surface using three‐dimensional images.Results –  For the cortical bone thickness, there was no statistically significant difference between the maxilla and the mandible in the anterior area; however, there was a significant difference in the posterior area. Cortical bone in the maxilla, mesial and distal to canine interradicular sites, was thickest while thickness in the mandible exhibited a gradual anterior to posterior increase. Cortical bone thickness in the maxilla increased as both level and angle increased, while the cortical bone thickness in the mandible was greatest at 4 mm from the alveolar crest. Root proximity mesial and distal to 2nd premolar interradicular sites was greatest.Conclusion –  Based on our results, cortical bone thickness depends on the interradicular site rather than sex or individual differences.
Simplified stress analysis on the temporomandibular joint in Class III patients with and without mandibular asymmetry using a rigid body spring model
Authors: Ueki K , Takeuchi N , Nakagawa K , Yamamoto E 
Published: October 2009

Structured AbstractAuthors –  Ueki K, Takeuchi N, Nakagawa K, Yamamoto EObjective –  Aim of this study was to investigate the differences in stress on the temporomandibular joint (TMJ) between Class III patients with and without mandibular asymmetry using a rigid body spring model (RBSM).Design –  Menton (Me), the centre point of occlusal force on the line that connected the bilateral buccal cusps of the second molars and the most lateral, superior and medial points of the condyle were plotted on frontal cephalograms, and stress on the condyles was calculated with the 2‐dimensional RBSM program of fortran.Setting and Sample Population –  Eighty Japanese patients with diagnosed mandibular prognathism were divided into two groups, a symmetry group and asymmetry group on the basis of the Mx‐Md midline position.Outcome measure –  The degree (force partition) of the resultant force, the direction (angulation) and displacement (X, Y) of each condyle were calculated. The horizontal displacement vector (u), the vertical displacement vector (v) and rotation angle (θ) of the mandibular body at Menton were also calculated.Results –  There were significant differences between the deviated and non‐deviated sides of both groups regarding resultant force (symmetry group: p = 0.0372, asymmetry group: p = 0.0054), X (symmetry group: p < 0.0001, asymmetry group: p = 0.0001) and Y (symmetry group: p = 0.0354, asymmetry group: p = 0.0043). For angulation, there was a significant difference between the deviated and non‐deviated sides in the asymmetry group (p = 0.0095).Conclusion –  The results of this study suggest that difference in stress angulation on the condyles could be associated with asymmetry in mandibular prognathism.
Cutaneous side effects of inhibition of VEGF signal transduction
Authors: Wozel Gottfried , Sticherling Michael , Schön Michael P. 
Published: October 2009

SummaryThe VEGF signaling pathway (including ligands, surface‐bound receptors and intracellular downstream signaling cascades) is critically involved in angiogenesis under normal and pathological conditions, in particular in malignant tumors. As a consequence, several therapies that target specific components of this pathway have been approved for clinical use or are in various stages of clinical development. Currently, the monoclonal antibodies bevacizumab and ranibizumab, as well as the small‐molecule kinase inhibitors sorafenib and sunitinib, have been approved for cancer therapy. The spectrum of cutaneous side effects elicited by bevacizumab is considerably less pronounced than that seen with EGF inhibitors and includes peripheral sensory neuropathy, stomatitis, skin dryness, skin discoloration and exfoliative dermatitis. In contrast, unwanted cutaneous side effects seen with the less specific small molecule compounds include pruritic exanthems, nail changes, cheilitis and the painful hand‐foot‐syndrome.
Primary mucinous eccrine carcinoma of the skin – a rare clinical tumor with many differential diagnoses
Authors: Scholz Ina M. , Hartschuh Wolfgang 
Published: October 2009

SummaryPrimary mucinous eccrine carcinoma of the skin is an extremely rare tumor most frequently occurring in the face or capillitium. It is felt to be an eccrine carcinoma, characterized by slow progress and unpredictable locally infiltrative growth. Therefore micrographic surgery is important to avoid local recurrence. It can be difficult to differentiate this carcinoma histologically from cutaneous metastases of breast or gastrointestinal tumors. Because of this, a primary staging in affected patients is essential.
Original Research—Women’s Sexual Health: Successful Transcutaneous Electrical Nerve Stimulation in Two Women with Restless Genital Syndrome: The Role of Aδ- and C-Nerve Fibers
Authors: Waldinger Marcel D. , De Lint Govert J. , Venema Pieter L. , Van Gils Ad P.G. , Schweitzer Dave H. 
Published: October 2009

ABSTRACTIntroductionCurrently, efficacious treatment of restless genital syndrome (ReGS) is not available.AimThis study aimed to report the results of transcutaneous electrical nerve stimulation (TENS) for ReGS, being a combination of genital dysesthesias, imminent and/or spontaneous orgasms, and/or restless legs, and/or overactive bladder.MethodsTwo women with ReGS were referred to our clinic. In-depth interview, routine and hormonal investigations, electroencephalography, magnetic resonance imaging (MRI) of the brain and pelvis, manual examination of the ramus inferior of the pubic bone, and sensory testing of genital dermatomes were performed. Conventional TENS (frequency: 110 Hz; pulse width: 80 milliseconds) was applied bilaterally at the region of the pudendal dermatome in which immediate reduction of genital sensations occurred. Patients were instructed for self-application of TENS each day for 2 months.Main Outcome MeasuresOral report, questionnaires on frequency of imminent and/or spontaneous orgasms, combined with questions on intensity of restless genital feelings, restless leg syndrome (RLS), overactive bladder syndrome (OAB), and satisfaction with TENS treatment.ResultsReGS in a 56-year-old woman manifested as multiple spontaneous orgasms, RLS, and OAB. TENS applied to the sacral region resulted in immediate reduction of complaints and a 90% reduction of spontaneous orgasms, RLS, and OAB in 2 months. ReGS in a 61-year-old woman manifested as a continuous restless genital feeling, imminent orgasms, and OAB. TENS applied to the pubic bone resulted in a complete disappearance of restlessness in the genital area as well as OAB complaints in 2 months. Both women reported to be very satisfied and did not want to stop TENS treatment.ConclusionsConventional TENS treatment is a promising therapy for ReGS, but further controlled research is warranted. Preorgasmic and orgasmic genital sensations in ReGS are transmitted by Aδ and C fibers and are inhibited by Aβ fibers. A neurological hypothesis on the pathophysiology of ReGS encompassing its clinical symptomatology, TENS, and drug treatment is put forward.