bluuebunny/crossref_metadata_2025_split huggingface dataset:
Precisely Controlling Polymer Acceptors with Weak Intramolecular Charge Transfer Effect and Superior Coplanarity for Efficient Indoor All‐Polymer Solar Cells with over 27% Efficiency
Authors: Zou Bosen , Ng Ho Ming , Yu Han , Ding Pengbo , Yao Jia , Chen Dezhang , Pun Sai Ho , Hu Huawei , Ding Kan , Ma Ruijie , Qammar Memoona , Liu Wei , Wu Weiwei , Lai Joshua Yuk Lin , Zhao Chaoyue , Pan Mingao , Guo Liang , Halpert Jonathan E. , Ade Harald , Li Gang , Yan He 
Published: May 2024

AbstractIndoor photovoltaics (IPVs) are garnering increasing attention from both the academic and industrial communities due to the pressing demand of the ecosystem of Internet‐of‐Things. All‐polymer solar cells (all‐PSCs), emerging as a sub‐type of organic photovoltaics, with the merits of great film‐forming properties, remarkable morphological and light stability, hold great promise to simultaneously achieve high efficiency and long‐term operation in IPV's application. However, the dearth of polymer acceptors with medium‐bandgap has impeded the rapid development of indoor all‐PSCs. Herein, a highly efficient medium‐bandgap polymer acceptor (PYFO‐V) is reported through the synergistic effects of side chain engineering and linkage modulation and applied for indoor all‐PSCs operation. As a result, the PM6:PYFO‐V‐based indoor all‐PSC yields the highest efficiency of 27.1% under LED light condition, marking the highest value for reported binary indoor all‐PSCs to date. More importantly, the blade‐coated devices using non‐halogenated solvent (o‐xylene) maintain an efficiency of over 23%, demonstrating the potential for industry‐scale fabrication. This work not only highlights the importance of fine‐tuning intramolecular charge transfer effect and intrachain coplanarity in developing high‐performance medium‐bandgap polymer acceptors but also provides a highly efficient strategy for indoor all‐PSC application.
IL‐37 possesses both anti‐inflammatory and antiviral effects against Middle East respiratory syndrome coronavirus infection
Authors: Qi Feifei , Yan Yiwei , Lv Qi , Liu Mingya , Liu Ming , Li Fengdi , Deng Ran , Liang Xujian , Li Shuyue , Mou Guocui , Bao Linlin 
Published: May 2024

AbstractBackgroundThe aim was to elucidate the function of IL‐37 in middle east respiratory syndrome coronavirus (MERS‐CoV) infection, thereby providing a novel therapeutic strategy for managing the clinical treatment of inflammatory response caused by respiratory virus infection.MethodsWe investigated the development of MERS by infecting hDPP4 mice with hCoV‐EMC (107 TCID50 [50% tissue culture infectious dose]) intranasally. We infected A549 cells with MERS‐CoV, which concurrently interfered with IL‐37, detecting the viral titer, viral load, and cytokine expression at certain points postinfection. Meanwhile, we administered IL‐37 (12.5 μg/kg) intravenously to hDPP4 mice 2 h after MERS‐CoV‐2 infection and collected the serum and lungs 5 days after infection to investigate the efficacy of IL‐37 in MERS‐CoV infection.ResultsThe viral titer of MERS‐CoV‐infected A549 cells interfering with IL‐37 was significantly reduced by 4.7‐fold, and the viral load of MERS‐CoV‐infected hDPP4 mice was decreased by 59‐fold in lung tissue. Furthermore, the administration of IL‐37 suppressed inflammatory cytokine and chemokine (monocyte chemoattractant protein 1, interferon‐γ, and IL‐17A) expression and ameliorated the infiltration of inflammatory cells in hDPP4 mice.ConclusionIL‐37 exhibits protective properties in severe pneumonia induced by MERS‐CoV infection. This effect is achieved through attenuation of lung viral load, suppression of inflammatory cytokine secretion, reduction in inflammatory cell infiltration, and mitigation of pulmonary injury.
Efficient Hydrogen Generation from Ammonia Borane Hydrolysis on a Tandem Ruthenium–Platinum–Titanium Catalyst
Authors: Guan Shuyan , Yuan Zhenluo , Zhao Shiqian , Zhuang Zechao , Zhang Huanhuan , Shen Ruofan , Fan Yanping , Li Baojun , Wang Dingsheng , Liu Baozhong 
Published: May 2024

AbstractHydrolysis of ammonia borane (NH3BH3, AB) involves multiple undefined steps and complex adsorption and activation, so single or dual sites are not enough to rapidly achieve the multi‐step catalytic processes. Designing multi‐site catalysts is necessary to enhance the catalytic performance of AB hydrolysis reactions but revealing the matching reaction mechanisms of AB hydrolysis is a great challenge. In this work, we propose to construct RuPt−Ti multi‐site catalysts to clarify the multi‐site tandem activation mechanism of AB hydrolysis. Experimental and theoretical studies reveal that the multi‐site tandem mode can respectively promote the activation of NH3BH3 and H2O molecules on the Ru and Pt sites as well as facilitate the fast transfer of *H and the desorption of H2 on Ti sites at the same time. RuPt−Ti multi‐site catalysts exhibit the highest turnover frequency (TOF) of 1293 min−1 for AB hydrolysis reaction, outperforming the single‐site Ru, dual‐site RuPt and Ru−Ti catalysts. This study proposes a multi‐site tandem concept for accelerating the dehydrogenation of hydrogen storage material, aiming to contribute to the development of cleaner, low‐carbon, and high‐performance hydrogen production systems.
Clamp for Safety: Improving Intravesical Chemotherapy Practices
Authors: Robison Michelle , Bush Nancy Jo 
Published: May 2024

ABSTRACTProcesses for intravesical chemotherapy after transurethral resection of nonmuscle invasive bladder tumors may lack standardization. In 2019, at a large health care system in Los Angeles, California, five incident reports involving chemotherapeutic agent spills from urinary catheters after bladder tumor procedures necessitated a quality improvement project. The project lead determined that a cost‐effective alternative device for securing the chemotherapeutic agent in the bladder was needed at four surgical locations of the health care system. In addition, a review of the literature and an observational assessment revealed lack of adherence to standard and recommended processes for using personal protective equipment (PPE) when handling hazardous medications. After revising existing processes, acquiring a cost‐effective clamp and recommended chemotherapy PPE, instructing personnel on the clamping process and use of PPE, and implementing use of the clamp, there have been no spills associated with intravesical chemotherapy across the four surgical locations.
Surface modification for enhanced Anti‐Wetting properties of electrospun omniphobic membranes in membrane distillation
Authors: Abid Monis Bin , Gzara Lassaad , Wahab Roswanira Abdul , Moujdin Iqbal Ahmed , Baig Nadeem , Shamim Aisha , Salam Mohamed Abdel 
Published: May 2024

AbstractMembrane wetting caused by substances in the feed solution with low surface tension has posed serious issues for membrane distillation (MD). Omniphobic membranes could be helpful when dealing with this problem because they strongly repel liquids with a wide range of surface tensions. We fabricated electrospun omniphobic membranes containing PVDF‐TEOS‐PFDTMS, PVDF‐HFP‐TMOS‐PFDTMS, and PVDF‐HFP‐TEOS‐PFDTMS. All electrospun membranes have shown contact angles >90°, but the electrospun membrane containing PVDF‐HFP‐TEOS‐PFDTMS has shown super repellence with a contact angle >150° and maintains stable salt rejection and water flux in direct contact MD processes in the presence of sodium dodecyl sulfate surfactant (up to 0.3 mM). Furthermore, the morphology and crystallinity of the electrospun membranes were studied by scanning electron microscopy and Fourier‐transform infrared spectroscopy, and the percentage composition of elements was analyzed by x‐ray photoelectron spectroscopy. liquid entry pressure, mechanical strength, and the porosity of the electrospun omniphobic membranes were also studied.
Multifunctional and high‐stability RGO/PANI wrapped polyurethane foam for flexible piezoresistive sensor applications
Authors: Gai Bowen , Li Shuai , Zhang Jun , Jiang Zhiguo , Xie Gang , Zhang Jianfu , Xing Shanshan , Yao Ming 
Published: May 2024

AbstractDue to its excellent durability and steady mechanical qualities, three‐dimensional porous polyurethane foam (PUF) presents a wide range of possibilities for flexible piezoresistive sensors. Its extreme flammability, poor electrical conductivity, and susceptibility to outside factors present serious difficulties, though. In this study, a waterborne polyurethane‐coated flexible PUF sensor that incorporates reduced graphene oxide (RGO) and polyaniline (PANI) through a methodical, step‐by‐step dip‐coating methodology is successfully developed. The final product has a water contact angle of 133°, which improves its ability to adapt to a variety of environmental circumstances. Flexible graphene sheets are incorporated to improve heat resistance and flame retardancy, and PANI and RGO provide strong bonding to the PUF framework, ensuring outstanding structural stability even after 1500 cycles. The flexible foam sensor shows promise for use in flexible piezoresistive sensors and electronic skin due to its remarkable strain monitoring range of up to 70%, quick response time of 0.39 s in sensitivity experiments, and adaptability to different physical activities like walking and gesturing.
JWST imaging of the closest globular clusters—I. Possible infrared excess among white dwarfs in NGC 6397
Authors: Bedin L. R. , Nardiello D. , Salaris M. , Libralato M. , Bergeron P. , Burgasser A. J. , Apai D. , Griggio M. , Scalco M. , Anderson J. , Gerasimov R. , Bellini A. 
Published: May 2024

AbstractWe present James Webb Space Telescope observations of the globular cluster NGC 6397 and use them to extend to infrared wavelengths the characterization of the cluster's entire white dwarf (WD) cooling sequence (CS). The data allows us to probe fundamental astrophysical WD properties and to search for evidence in their colors for (or against) the existence of ancient planetary systems. The existing archival Hubble Space Telescope imaging data obtained years ago reach ultra‐deep optical magnitudes () and allow us to derive a near‐perfect separation between field and cluster members. We detect an apparent split in the lower part of the WD CS of NGC 6397. The red part of the WD CS, containing about 25% of the total, exhibits significant IR‐excess of up to mag. These infrared excesses require both theoretical and observational follow‐ups to confirm their veracity and to ascertain their true nature.
Research Progress, Challenges, and Prospects of High Energy Density Aqueous Aluminum‐Ion Batteries: A Mini‐Review
Authors: Yuan Xuelong , Lin Zhifeng , Duan Yichen , Chen Zhichao , Fu Lijun , Chen Yuhui , Liu Lili , Yuan Xinhai , Wu Yuping 
Published: May 2024

AbstractAmong emerging rechargeable batteries, rechargeable aluminum‐ion batteries (AIBs) stand out for their high specific capacities and the abundance of aluminum, positioning them as an attractive electrochemical energy storage option. Despite the superior electrochemical performance of non‐aqueous AIBs, aqueous aluminum‐ion batteries (AAIBs) have garnered extensive research interest for their low cost and enhanced safety. Yet, realizing high energy density in AAIBs poses significant challenges. This article systematically reviews strategies and recent advancements in cathodes, anodes, and electrolytes aimed at achieving high energy density in AAIBs. It concludes with a forward‐looking perspective on the design of AAIBs with high energy density and prolonged cycle life, highlighting promising directions for future researches.
Combined approach of selective and accelerated cloning for microfluidic chip‐based system increases clone specific productivity
Authors: Desmurget Caroline , Frentzel Julie , Strembitska Anastasiya , Sobkowiak Katarzyna , Perilleux Arnaud , Souquet Jonathan , Borth Nicole , Douet Julien 
Published: May 2024

AbstractImproving current cell line development workflows can either focus on increasing the specific productivity of the cell lines or shortening timelines to reach the clinic as fast as possible. In this work, using the Beacon platform, we have combined two distinct protocols – early cloning with low‐viability pools, and IgG membrane staining‐, to concomitantly reach both objectives, and generate highly productive CHO clones in shorter timelines. Fast‐sorting approaches using low‐viability pools in combination with the Beacon platform have recently been reported to shorten CLD timelines. However, the low recovery led to a drastic reduction in the clone number obtained postcloning. Here, we report a combined approach of fast‐sorting and fluorescent membrane staining. With this new protocol, the cells reach a correct recovery, allowing to fully exploit the Beacon screening capacities. In addition, by using a fluorescent staining recognizing the secreted IgG, we were able to enrich the fraction of highly secreting cells prior to cloning and we obtained significant increases in the cell's specific productivity. The combination of these two protocols has a synergistic effect, and as they help discarding the dead and nonproducing populations prior to cloning, they increase the throughput power of the Beacon platform and the detection of super productive clones.
Postsynthetic Modification of Hydrogen‐Bonded Frameworks
Authors: Han Zongsu , Wang Mengmeng , Shi Wei 
Published: May 2024

AbstractHydrogen‐bonded frameworks have garnered significant attention due to their flexible structures with tailored porosity, making them a promising class of porous framework materials. However, the direct synthesis of hydrogen‐bonded frameworks with specific functions is highly challenging due to the unpredictable formation of hydrogen‐bonded frameworks. In response, postsynthetic modification has emerged as a potent strategy to imbue desired functions into hydrogen‐bonded frameworks. Recent advances have demonstrated the effectiveness of postsynthetic modification in hydrogen‐bonded frameworks for studying their mechanical, luminescent, electrochemical, and chiral properties. In this concept, we comprehensively summarize the methodologies and outcomes of postsynthetic modification to hydrogen‐bonded frameworks, providing a highlight of this exciting research area.
Characterization of Germanium Nanoparticles from Arylgermanium Trihydrides
Authors: Schmid Philipp , Bitschnau Brigitte , Finšgar Matjaž , Letofsky‐Papst Ilse , Rattenberger Johannes , Saf Robert , Uhlig Frank , Torvisco Ana 
Published: May 2024

AbstractGermanium is a promising basis for nanomaterials due to its low toxicity and valuable optical and electronic properties. However, germanium nanomaterials have seen little research compared to other group 14 elements due to unpredictable chemical behavior and high costs. Here, we report the dehydrocoupling of o‐tolylgermanium trihydride to amorphous nanoparticles. The reaction is facilitated through reflux at 162 °C and can be accelerated with an amine base catalyst. Through cleavage of both H2 and toluene, new Ge−Ge bonds form. This results in nanoparticles consisting of crosslinked germanium with o‐tolyl termination. The particles are 2–6 nm in size and have masses above approximately 3500 Da. The organic substituents are promising for further functionalization. Combined with strong absorption up to 600 nm and moderate solubility and air stability, there are numerous possibilities for future applications.
Who is Who in the Carbene Chemistry of N‐Sulfonyl Hydrazones
Authors: Sivaguru Paramasivam , Pan Yongzhen , Wang Nan , Bi Xihe 
Published: May 2024

Comprehensive SummaryOver the past few decades, N‐sulfonyl hydrazones have been recognized as alternative precursors for hazardous diazo compounds in organic synthesis, allowing for diverse innovative and original chemical transformations that were otherwise difficult to achieve. This critical review summarizes the major advancements in the carbene chemistry of N‐sulfonyl hydrazones. The contents of this review are organized based on research conducted by leading scientists who have made significant contributions to this field. The individual carbene transfer reactions and their mechanisms, as well as the potential applications in the synthesis of natural products and complex bioactive molecules, are thoroughly discussed.
Sexual health in adult survivors of childhood cancer: A Project REACH study
Authors: Chevalier Lydia L. , McCormick Katherine , Cooney Tabitha M. , Recklitis Christopher J. , Bober Sharon L. 
Published: May 2024

AbstractBackgroundSexual dysfunction is a significant complication of treatment for many adult‐onset cancers. However, comparatively less is known about sexual dysfunction in adult childhood cancer survivors (CCSs). Research has been limited by the exclusion of specific cancers (e.g., central nervous system [CNS] tumors) and the lack of validated measures, which makes it difficult to understand the nature and prevalence of sexual dysfunction in CCSs.MethodsA total of 249 adult CCSs (aged 18–65 years) enrolled in Project REACH, a prospective cohort study, and completed measures of physical and mental health, including sexual dysfunction. Participants scoring ≤19 on the Female Sexual Function Index 6 or ≤21 on the International Index of Erectile Function 5 were classified as experiencing sexual dysfunction. Analyses examined the relationships between sexual dysfunction and demographic, disease, treatment, and health variables.ResultsA total of 78 participants (32%) experienced clinically significant sexual dysfunction. In univariate analysis, sexual dysfunction was significantly associated with CNS tumor diagnosis (odds ratio [OR], 2.56) and surgery (OR, 1.96) as well as with health variables such as fatigue (OR, 3.00), poor sleep (OR, 2.84), pain (OR, 2.04), depression (OR, 2.64), poor physical health (OR, 2.45), and poor mental health (OR, 2.21). Adjusted analyses found that CNS tumor diagnosis (p = .001) and health variables (p = .025) contribute significantly to sexual dysfunction in CCSs.ConclusionsApproximately one third of adult CCSs report clinically significant sexual dysfunction, which underscores a significant screening and treatment need. However, because available measures were developed for survivors of adult cancers, research to create a sexual health measure specifically for adult CCSs is necessary to better identify the sexual health concerns of this vulnerable population.
Hyperphosphorylated tau in Alzheimer's disease disseminates along pathways predicted by the Structural Model for Cortico‐cortical Connections
Authors: Uceda‐Heras Alicia , Aparicio‐Rodríguez Gonzalo , García‐Cabezas Miguel Ángel 
Published: May 2024

AbstractIn Alzheimer´s disease (AD), hyperphosphorylated tau spreads along the cerebral cortex in a stereotypical pattern that parallels cognitive deterioration. Tau seems to spread transsynaptically along cortico‐cotical pathways that, according to synaptic tract‐tracing studies in nonhuman primates, have specific laminar patterns related to the cortical type of the connected areas. This relation is described in the Structural Model. In the present article, we study the laminar distribution of hyperphosphorylated tau, labeled with the antibody AT8, along temporal cortical types in postmortem human brains with different AD stages to test the predictions of the Structural Model. Brains from donors without dementia had scant AT8‐immunorreactive (AT8‐ir) neurons in allo‐, meso‐, and isocortical types. In early AD stages, the mesocortical dysgranular type, including part of the transentorhinal cortex, had the highest AT8 immunostaining and AT8‐ir neurons density. In advanced AD stages, AT8 immunostaining increased along the isocortical types until reaching the auditory koniocortex. Regarding laminar patterns, in early AD stages there were more AT8‐ir neurons in supragranular layers in each de novo involved neocortical type; in advanced AD stages, AT8‐ir neurons were equally distributed in supra‐ and infragranular layers. These AT8‐ir laminar patterns are compatible with the predictions of the Structural Model. In summary, we show that hyperphosphorylated tau initially accumulates in allo‐, meso‐, and isocortical types, offer a proof of concept for the validity of the Structural Model to predict synaptic pathway organization in the human cerebral cortex, and highlight the relevance of nonhuman primate tract‐tracing studies to understand human neuropathology.
Copper in colorectal cancer: From copper‐related mechanisms to clinical cancer therapies
Authors: Wang Yuhong , Pei Pei , Yang Kai , Guo Lingchuan , Li Yuan 
Published: May 2024

AbstractCopper, a trace element and vital cofactor, plays a crucial role in the maintenance of biological functions. Recent evidence has established significant correlations between copper levels, cancer development and metastasis. The strong redox‐active properties of copper offer both benefits and disadvantages to cancer cells. The intestinal tract, which is primarily responsible for copper uptake and regulation, may suffer from an imbalance in copper homeostasis. Colorectal cancer (CRC) is the most prevalent primary cancer of the intestinal tract and is an aggressive malignant disease with limited therapeutic options. Current research is primarily focused on the relationship between copper and CRC. Innovative concepts, such as cuproplasia and cuproptosis, are being explored to understand copper‐related cellular proliferation and death. Cuproplasia is the regulation of cell proliferation that is mediated by both enzymatic and nonenzymatic copper‐modulated activities. Whereas, cuproptosis refers to cell death induced by excess copper via promoting the abnormal oligomerisation of lipoylated proteins within the tricarboxylic acid cycle, as well as by diminishing the levels of iron‐sulphur cluster proteins. A comprehensive understanding of copper‐related cellular proliferation and death mechanisms offers new avenues for CRC treatment. In this review, we summarise the evolving molecular mechanisms, ranging from abnormal intracellular copper concentrations to the copper‐related proteins that are being discovered, and discuss the role of copper in the pathogenesis, progression and potential therapies for CRC. Understanding the relationship between copper and CRC will help provide a comprehensive theoretical foundation for innovative treatment strategies in CRC management.
Juvenile survival increases with dispersal distance and varies across years: 15 years of evidence in a prairie perennial
Authors: Richardson Lea K. , Nordstrom Scott W. , Waananen Amy , Thoen Riley D. , Dykstra Amy B. , Kiefer Gretel , Mullett Drake E. , Eichenberger Erin G. , Shaw Ruth G. , Wagenius Stuart 
Published: May 2024

AbstractJuvenile survival is critical to population persistence and evolutionary change. However, the survival of juvenile plants from emergence to reproductive maturity is rarely quantified. This is especially true for long‐lived perennials with extended pre‐reproductive periods. Furthermore, studies rarely have the replication necessary to account for variation among populations and cohorts. We estimated juvenile survival and its relationship to population size, density of conspecifics, distance to the maternal plant, age, year, and cohort for Echinacea angustifolia, a long‐lived herbaceous perennial. In 14 remnant prairie populations over seven sampling years, 2007–2013, we identified 886 seedlings. We then monitored these individuals annually until 2021 (8–15 years). Overall, juvenile mortality was very high; for almost all cohorts fewer than 10% of seedlings survived to age 8 or to year 2021. Only two of the seedlings reached reproductive maturity within the study period. Juvenile survival increased with distance from the maternal plant and varied more among the study years than it did by age or cohort. Juvenile survival did not vary with population size or local density of conspecific neighbors. Our results suggest that low juvenile survival could contribute to projected population declines.