bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Miocene-to-Present Kinematic Evolution of the Eastern Mediterranean and Middle East and Its Implications for Dynamics
Authors: Le Pichon Xavier , Kreemer Corné 
Published: April 2010

The present kinematics in the eastern Mediterranean and Middle East is now well constrained by GPS measurements and dominated by a circular counterclockwise motion. While Arabia rotates rigidly, the rotational velocities increase from the Levant to Aegea, causing extension in western Anatolia. We place the present pattern in light of the post–Middle Miocene geological history and propose that in addition to the effects of the Hellenic subduction and Zagros collision-subduction zones on driving the surface motion, an underlying asthenospheric flow is also required. This counterclockwise toroidal flow is expected to exist around the eastern edge of the African slab owing to subduction rollback, and it helps explain the initiation of the North Anatolia Fault, the extrusion and uplift of Anatolia, and the Mid-Miocene to Recent volcanism in eastern Anatolia. The Afar plume had a similar effect on the acceleration of Arabia at 40 Mya.
Forming Planetesimals in Solar and Extrasolar Nebulae
Authors: Chiang E. , Youdin A.N. 
Published: April 2010

Planets are built from planetesimals: solids larger than a kilometer that grow by colliding in pairs. Planetesimals themselves are unlikely to form by two-body collisions alone; subkilometer objects have gravitational fields individually too weak, and electrostatic attraction is too feeble for growth beyond a few centimeters. We review the possibility that planetesimals form when self-gravity brings together vast ensembles of small particles. Even when self-gravity is weak, aerodynamic processes can accumulate solids relative to gas, paving the way for gravitational collapse. Particles pile up as they drift radially inward. Gas turbulence stirs particles but can also seed collapse by clumping them. Whereas the feedback of solids on gas triggers vertical-shear instabilities that obstruct self-gravity, this same feedback triggers streaming instabilities that strongly concentrate particles. Numerical simulations find that solids ∼10–100 cm in size gravitationally collapse in turbulent disks. We outline areas for progress, including the possibility that still smaller objects self-gravitate.
Lessons Learned from the 2004 Sumatra-Andaman Megathrust Rupture
Authors: Shearer Peter , Bürgmann Roland 
Published: April 2010

The 2004 Sumatra-Andaman earthquake has been extensively studied because of its great size and devastating consequences. Large amounts of high-quality seismic, geodetic, and geologic data have led to a number of proposed models for its length, duration, fault geometry, rupture velocity, and slip history. The latest of these models vary in their details but now largely agree in their large-scale features, which include significant coseismic slip along the entire 1300- to 1500-km rupture, the bulk of which occurred fast enough to radiate seismic waves. The earthquake's enormous size has challenged conventional processing approaches and stimulated the development of new analysis and inversion methods, including multiple-source inversions, high-frequency body-wave imaging, and satellite observations of tsunami heights and gravity changes. The Sumatra megathrust earthquake was the largest in 40 years and is by far the best documented, but it does not seem fundamentally different in its properties from other large subduction-zone earthquakes.
The Hellenic Subduction System: High-Pressure Metamorphism, Exhumation, Normal Faulting, and Large-Scale Extension
Authors: Ring Uwe , Glodny Johannes , Will Thomas , Thomson Stuart 
Published: April 2010

The Cenozoic history of the retreating Hellenic subduction system in the eastern Mediterranean involves subduction, accretion, arc magmatism, exhumation, normal faulting, and large-scale continental extension from ∼60 Mya until the Recent. Ages for high-pressure metamorphism in the central Aegean Sea region range from ∼53 Ma in the north (the Cyclades islands) to ∼25−20 Ma in the south (Crete). Younging of high-pressure metamorphism reflects the southward retreat of the Hellenic subduction zone. The shape of pressure-temperature-time paths of high-pressure rocks is remarkably similar across all tectonic units, suggesting a steady-state thermal profile of the subduction system and persistence of deformation and exhumation styles. The high-pressure metamorphic events were caused by the underthrusting of fragments of continental crust that were superimposed on slab retreat. Most of the exhumation of high-pressure units occurred in extrusion wedges during ongoing lithospheric convergence. At 23–19 Mya large-scale lithospheric extension commenced, causing metamorphic core complexes and the opening of the Aegean Sea basin. This extensional stage caused limited exhumation at the margins of the Aegean Sea but accomplished the major part of the exhumation of high-grade rocks that formed between 21 and 16 Mya in the central Aegean. The age pattern of extensional faults and contoured maps of fission-track cooling ages do not show a simple southward progression. Our review of lithologic, structural, metamorphic, and geochronologic data is consistent with a temporal link between the draping of the subducted slab over the 660-km discontinuity and the large-scale extension causing the opening of the Aegean Sea basin.
Exercise Training in Patients With Advanced Chronic Heart Failure (NYHA IIIb) Promotes Restoration of Peripheral Vasomotor Function, Induction of Endogenous Regeneration, and Improvement of Left Ventricular Function
Authors: Erbs Sandra , Höllriegel Robert , Linke Axel , Beck Ephraim B. , Adams Volker , Gielen Stephan , Möbius-Winkler Sven , Sandri Marcus , Kränkel Nicolle , Hambrecht Rainer , Schuler Gerhard 
Published: April 2010

Background—
Attenuated peripheral perfusion in patients with advanced chronic heart failure (CHF) is partially the result of endothelial dysfunction. This has been causally linked to an impaired endogenous regenerative capacity of circulating progenitor cells (CPC). The aim of this study was to elucidate whether exercise training (ET) affects exercise intolerance and left ventricular (LV) performance in patients with advanced CHF (New York Heart Association class IIIb) and whether this is associated with correction of peripheral vasomotion and induction of endogenous regeneration.

Methods and Results—

Thirty-seven patients with CHF (LV ejection fraction 24±2%) were randomly assigned to 12 weeks of ET or sedentary lifestyle (control). At the beginning of the study and after 12 weeks, maximal oxygen consumption (V
o
2
max) and LV ejection fraction were determined; the number of CD34
+
/KDR
+
CPCs was quantified by flow cytometry and CPC functional capacity was determined by migration assay. Flow-mediated dilation was assessed by ultrasound. Capillary density was measured in skeletal muscle tissue samples. In advanced CHF, ET improved V
o
2
max by +2.7±2.2 versus −0.8±3.1 mL/min/kg in control (
P
=0.009) and LV ejection fraction by +9.4±6.1 versus −0.8±5.2% in control (
P
<0.001). Flow-mediated dilation improved by +7.43±2.28 versus +0.09±2.18% in control (
P
<0.001). ET increased the number of CPC by +83±60 versus −6±109 cells/mL in control (
P
=0.014) and their migratory capacity by +224±263 versus −12±159 CPC/1000 plated CPC in control (
P
=0.03). Skeletal muscle capillary density increased by +0.22±0.10 versus −0.02±0.16 capillaries per fiber in control (
P
<0.001).

Conclusions—
Twelve weeks of ET in patients with advanced CHF is associated with augmented regenerative capacity of CPCs, enhanced flow-mediated dilation suggestive of improvement in endothelial function, skeletal muscle neovascularization, and improved LV function.

Clinical Trial Registration—

http://www.clinicaltrials.gov
. Unique Identifier: NCT00176384.
Extended Molecular Evolutionary Biology: Artificial Life Bridging the Gap Between Chemistry and Biology
Authors: Schuster P. 
Published: April 2010

Molecular evolution provides an ample field for the extension of Nature's principles towards novel applications. Several examples are discussed here, among them are evolution in the test tube, nucleotide chemistry with new base pairs and new backbones, enzyme-free replication of polynucleotides and template chemistry aiming at replicating structures that have nothing in common with the molecules from nature. Molecular evolution in the test tube provides a uniquely simple system for the study of evolutionary phenomena: genotype and phenotype are two features of one and the same RNA molecule. Then fitness landscapes are nothing more than combined mappings from sequences to structures and from structures to functions, the latter being expressed in terms of rate constants. RNA landscapes are presented as examples for which an access to phenomena in reality by mathematical analysis and computer simulations is feasible. New questions concerning stability of structures in evolution can be raised and quantitative answers are given. Evolutionary biotechnology is a spin-off from molecular evolution. Darwin's principle of variation and selection is applied to design novel biopolymers with predetermined functions. Different approaches to achieve this goal are discussed and a survey of the current state of the art is given.
Evolving 3D Morphology and Behavior by Competition
Authors: Sims Karl 
Published: April 2010

This article describes a system for the evolution and coevolution of virtual creatures that compete in physically simulated three-dimensional worlds. Pairs of individuals enter one-on-one contests in which they contend to gain control of a common resource. The winners receive higher relative fitness scores allowing them to survive and reproduce. Realistic dynamics simulation including gravity, collisions, and friction, restricts the actions to physically plausible behaviors. The morphology of these creatures and the neural systems for controlling their muscle forces are both genetically determined, and the morphology and behavior can adapt to each other as they evolve simultaneously. The genotypes are structured as directed graphs of nodes and connections, and they can efficiently but flexibly describe instructions for the development of creatures' bodies and control systems with repeating or recursive components. When simulated evolutions are performed with populations of competing creatures, interesting and diverse strategies and counterstrategies emerge.
Radical Epistasis and the Genotype-Phenotype Relationship
Authors: Wilson David Sloan , Wells Alexandra 
Published: April 2010

Models of evolution often assume that the offspring of two genotypes, which are genetically intermediate by definition, are also phenotypically intermediate. The continuity between genotype and phenotype interferes with the process of evolution on multipeaked adaptive landscapes because the progeny of genotypes that lie on separate adaptive peaks fall into valleys of low fitness. This problem can be solved by epistasis, which disrupts the continuity between genotype and phenotype. In a five-locus sexual haploid model with maximum epistasis, natural selection in multipeak landscapes evolves a set of genotypes that a) occupy the adaptive peaks and b) give rise to each other by recombination. The epistatic genetic system therefore “molds” the phenotypic distribution to the adaptive landscape, without assortative mating or linkage disequilibrium. If the adaptive landscape is changed, a new set of genotypes quickly evolves that satisfies conditions a and b, above, for the new peaks. Our model may be relevant to a number of recalcitrant problems in biology and also stands in contrast to Kauffman's [3] NK model of evolution on rugged fitness surfaces, in which epistasis and recombination tend to constrain the evolutionary process.
Multiple von Neumann Computers: An Evolutionary Approach to Functional Emergence
Authors: Suzuki Hideaki 
Published: April 2010

A novel system composed of multiple von Neumann computers and an appropriate problem environment is proposed and simulated. Each computer has a memory to store the machine instruction program, and when a program is executed, a series of machine codes in the memory is sequentially decoded, leading to register operations in the central processing unit (CPU). By means of these operations, the computer not only can handle its generally used registers but also can read and write the environmental database. Simulation is driven by genetic algorithms (GAs) performed on the population of program memories. Mutation and crossover create program diversity in the memory, and selection facilitates the reproduction of appropriate programs. Through these evolutionary operations, advantageous combinations of machine codes are created and fixed in the population one by one, and the higher function, which enables the computer to calculate an appropriate number from the environment, finally emerges in the program memory.In the latter half of the article, the performance of GAs on this system is studied. Under different sets of parameters, the evolutionary speed, which is determined by the time until the domination of the final program, is examined and the conditions for faster evolution are clarified. At an intermediate mutation rate and at an intermediate population size, crossover helps create novel advantageous sets of machine codes and evidently accelerates optimization by GAs.
Modeling Malaria as a Complex Adaptive System
Authors: Janssen M. A. , Martens W. J. M. 
Published: April 2010

As the resistance of the malaria parasite to antimalarial drugs continues to increase, as does that of the malarial mosquito to insecticides, the efficacy of efforts to control malaria in many tropical countries is diminishing. This trend, together with the projected consequences of climate change, may prove to exacerbate substantially the significance of malaria in the coming decades. In this article we introduce the use of an evolutionary modeling approach to simulate the adaptation of mosquitoes and parasites to the available pesticides and drugs. By coupling genetic algorithms with a dynamic malaria-epidemiological model, we derive a complex adaptive system capable of simulating adapting and evolving processes within both the mosquito and the parasite populations. This approach is used to analyze malaria management strategies appropriate to regions of higher and lower degrees of endemicity. The results suggest that adequate use of insecticides and drugs may reduce the occurrence of malaria in regions of low endemicity, although increased efforts would be necessary in the event of a climate change. However, our model indicates that in regions of high endemicity the use of insecticides and drugs may lead to an increase in incidence due to enhanced resistance development. Projected climate change, on the other hand, may lead to a limited reduction of the occurrence of malaria due to the presence of a higher percentage of immune persons in the older age class.
Word or Word-like? Dissociating Orthographic Typicality from Lexicality in the Left Occipito-temporal Cortex
Authors: Woollams Anna M. , Silani Giorgia , Okada Kayoko , Patterson Karalyn , Price Cathy J. 
Published: April 2010

Abstract
Prior lesion and functional imaging studies have highlighted the importance of the left ventral occipito-temporal (LvOT) cortex for visual word recognition. Within this area, there is a posterior–anterior hierarchy of subregions that are specialized for different stages of orthographic processing. The aim of the present fMRI study was to dissociate the effects of subword orthographic typicality (e.g., cider [high] vs. cynic [low]) from the effect of lexicality (e.g., pollen [word] vs. pillen [pseudoword]). We therefore orthogonally manipulated the orthographic typicality of written words and pseudowords (nonwords and pseudohomophones) in a visual lexical decision task. Consistent with previous studies, we identified greater activation for pseudowords than words (i.e., an effect of lexicality) in posterior LvOT cortex. In addition, we revealed higher activation for atypical than typical strings, irrespective of lexicality, in a left inferior occipital region that is posterior to LvOT cortex. When lexical decisions were made more difficult in the context of pseudohomophone foils, left anterior temporal activation also increased for atypical relative to typical strings. The latter finding agrees with the behavior of patients with progressive anterior temporal lobe degeneration, who have particular difficulty recognizing words with atypical orthography. The most novel outcome of this study is that, within a distributed network of regions supporting orthographic processing, we have identified a left inferior occipital region that is particularly sensitive to the typicality of subword orthographic patterns.
Decoding Task-based Attentional Modulation during Face Categorization
Authors: Chiu Yu-Chin , Esterman Michael , Han Yuefeng , Rosen Heather , Yantis Steven 
Published: April 2010

Abstract
Attention is a neurocognitive mechanism that selects task-relevant sensory or mnemonic information to achieve current behavioral goals. Attentional modulation of cortical activity has been observed when attention is directed to specific locations, features, or objects. However, little is known about how high-level categorization task set modulates perceptual representations. In the current study, observers categorized faces by gender (male vs. female) or race (Asian vs. White). Each face was perceptually ambiguous in both dimensions, such that categorization of one dimension demanded selective attention to task-relevant information within the face. We used multivoxel pattern classification to show that task-specific modulations evoke reliably distinct spatial patterns of activity within three face-selective cortical regions (right fusiform face area and bilateral occipital face areas). This result suggests that patterns of activity in these regions reflect not only stimulus-specific (i.e., faces vs. houses) responses but also task-specific (i.e., race vs. gender) attentional modulation. Furthermore, exploratory whole-brain multivoxel pattern classification (using a searchlight procedure) revealed a network of dorsal fronto-parietal regions (left middle frontal gyrus and left inferior and superior parietal lobule) that also exhibit distinct patterns for the two task sets, suggesting that these regions may represent abstract goals during high-level categorization tasks.
High-resolution fMRI Reveals Match Enhancement and Attentional Modulation in the Human Medial Temporal Lobe
Authors: Dudukovic Nicole M. , Preston Alison R. , Archie Jermaine J. , Glover Gary H. , Wagner Anthony D. 
Published: April 2010

AbstractA primary function of the medial temporal lobe (MTL) is to signal prior encounter with behaviorally relevant stimuli. MTL match enhancement—increased activation when viewing previously encountered stimuli—has been observed for goal-relevant stimuli in nonhuman primates during delayed-match-to-sample tasks and in humans during more complex relational memory tasks. Match enhancement may alternatively reflect (a) an attentional response to familiar relative to novel stimuli or (b) the retrieval of contextual details surrounding the past encounter with familiar stimuli. To gain leverage on the functional significance of match enhancement in the hippocampus, high-resolution fMRI of human MTL was conducted while participants attended, ignored, or passively viewed face and scene stimuli in the context of a modified delayed-match-to-sample task. On each “attended” trial, two goal-relevant stimuli were encountered before a probe that either matched or mismatched one of the attended stimuli, enabling examination of the consequences of encountering one of the goal-relevant stimuli as a match probe on later memory for the other (nonprobed) goal-relevant stimulus. fMRI revealed that the hippocampus was insensitive to the attentional manipulation, whereas parahippocampal cortex was modulated by scene-directed attention, and perirhinal cortex showed more subtle and general effects of attention. By contrast, all hippocampal subfields demonstrated match enhancement to the probe, and a postscan test revealed more accurate recognition memory for the nonprobed goal-relevant stimulus on match relative to mismatch trials. These data suggest that match enhancement in human hippocampus reflects retrieval of other goal-relevant contextual details surrounding a stimulus's prior encounter.
A Role for the Striatum in Regret-related Choice Repetition
Authors: Nicolle Antoinette , Bach Dominik R. , Driver Jon , Dolan Raymond J. 
Published: April 2010

Abstract
“Regret aversion” is proposed to explain a tendency to avoid future choices that have induced past regret. However, regret might also motivate us to repeat previous regret-related choices to make up for their previous selection, a behavior resembling “chasing” in the context of gambling. In the current experiment, we acquired fMRI brain data while participants placed monetary bets on repeated gambles. Behaviorally, participants showed a tendency to repeat previously regret-related choices (operationalized as those leading to an outcome worse than what might have been), an effect restricted to early runs of the task. At gamble outcome, we show a reduction in ventral striatal activity for regret-related relative to relief-related outcomes. Critically, this modulation was only seen when subjects were responsible for the bet choice. Activity in dorsal striatum was associated with an influence of previous regret on participants' subsequent choices, which is evident in increased activity when regret-related choices were repeated, relative to avoided, on the next trial. Our findings indicate that regret can lead to choice repetition as if seeking to make up for our mistakes and in so doing may lead to subsequent chasing behavior.
Attention Extracts Signal in External Noise: A BOLD fMRI Study
Authors: Lu Zhong-Lin , Li Xiangrui , Tjan Bosco S. , Dosher Barbara A. , Chu Wilson 
Published: April 2010

Abstract
On the basis of results from behavioral studies that spatial attention improves the exclusion of external noise in the target region, we predicted that attending to a spatial region would reduce the impact of external noise on the BOLD response in corresponding cortical areas, seen as reduced BOLD responses in conditions with large amounts of external noise but relatively low signal, and increased dynamic range of the BOLD response to variations in signal contrast. We found that, in the presence of external noise, covert attention reduced the trial-by-trial BOLD response by 15.5–18.9% in low signal contrast conditions in V1. It also increased the BOLD dynamic range in V1, V2, V3, V3A/B, and V4 by a factor of at least three. Overall, covert attention reduced the impact of external noise by about 73–85% in these early visual areas. It also increased the contrast gain by a factor of 2.6–3.8.
Rebound Spiking as a Neural Mechanism for Surface Filling-in
Authors: Supèr Hans , Romeo August 
Published: April 2010

Abstract
Perceptual filling-in is the phenomenon where visual information is perceived although information is not physically present. For instance, the blind spot, which corresponds to the retinal location where there are no photoreceptor cells to capture the visual signals, is filled-in by the surrounding visual signals. The neural mechanism for such immediate filling-in of surfaces is unclear. By means of computational modeling, we show that surround inhibition produces rebound or after-discharge spiking in neurons that otherwise do not receive sensory information. The behavior of rebound spiking mimics the immediate surface filling-in illusion observed at the blind spot and also reproduces the filling-in of an empty object after a background flash, like in the color dove illusion. In conclusion, we propose rebound spiking as a possible neural mechanism for surface filling-in.