bluuebunny/crossref_metadata_2025_split huggingface dataset:
Knowledge mapping of paediatric fever—a visual analysis based on CiteSpace
Authors: Liu Di , Zhang Dingruo , Yu Tianyuan , Guo Sheng , Xue Xiaona , Hu Hui , Liu Jiayue , Xu Yue , Narentuya  
Published: May 2024

ObjectiveThis study aimed to analyse the research hotspots and frontiers in the field of paediatric fever between 2013 and 2023.MethodsThe included articles were visually analysed using CiteSpace 6.1.R6 software.ResultsA total of 2,662 Chinese-language articles and 1,456 English-language articles were included in the study. Based on the Chinese literature, research groups were identified represented by Xinmin Li, Jinling Hong and Hongshuang Luo. Based on the English literature, research groups were formed represented by Henriette Moll, Santiago Mintegi and Elizabeth Alpern. Tianjin University of Traditional Chinese Medicine was the institution with the largest number of publications in the Chinese literature, and the Centers For Disease Control And Prevention was the institution with the largest number of publications in the English literature. The research on paediatric fever mainly focused on mechanism exploration, green treatment and clinical management.ConclusionSeveral relatively stable research groups have been formed. Future studies on the differential diagnosis, rational drug use, standardised management and clinical practice guidelines for paediatric fever are needed.
Upregulation of GOLPH3 mediated by Bisphenol a promotes colorectal cancer proliferation and migration: evidence based on integrated analysis
Authors: Chen Lihua , Chen Shaojian , Li Yachen , Qiu Yi , Chen Xiaojing , Wu Yuze , Deng Xian , Chen Mingliang , Wang Chunxiao , Hong Zhongshi , Qiu Chengzhi 
Published: May 2024

BackgroundThe interaction between environmental endocrine-disrupting chemicals, such as Bisphenol A (BPA), and their influence on cancer progression, particularly regarding the GOLPH3 gene in colorectal cancer, remains unclear.MethodsWe performed an integrated analysis of transcriptional profiling, clinical data, and bioinformatics analyses utilizing data from the Comparative Toxicogenomics Database and The Cancer Genome Atlas. The study employed ClueGO, Gene Set Enrichment Analysis, and Gene Set Variation Analysis for functional enrichment analysis, alongside experimental assays to examine the effects of BPA exposure on colorectal cancer cell lines, focusing on GOLPH3 expression and its implications for cancer progression.ResultsOur findings demonstrated that BPA exposure significantly promoted the progression of colorectal cancer by upregulating GOLPH3, which in turn enhanced the malignant phenotype of colorectal cancer cells. Comparative analysis revealed elevated GOLPH3 protein levels in cancerous tissues versus normal tissues, with single-cell analysis indicating widespread GOLPH3 presence across various cell types in the cancer microenvironment. GOLPH3 was also associated with multiple carcinogenic pathways, including the G2M checkpoint. Furthermore, our investigation into the colorectal cancer microenvironment and genomic mutation signature underscored the oncogenic potential of GOLPH3, exacerbated by BPA exposure.ConclusionThis study provides novel insights into the complex interactions between BPA exposure and GOLPH3 in the context of colorectal cancer, emphasizing the need for heightened awareness and measures to mitigate BPA exposure risks. Our findings advocate for further research to validate these observations in clinical and epidemiological settings and explore potential therapeutic targets within these pathways.
Identifying the differentially expressed peripheral blood microRNAs in psychiatric disorders: a systematic review and meta-analysis
Authors: Liu Xiaoyan , Dong Liying , Jiang Zhaowei , Song Mingfen , Yan Pan 
Published: May 2024

BackgroundEvidence has suggested that microRNAs (miRNAs) may play an important role in the pathogenesis of psychiatric disorders (PDs), but the results remain inconclusive. We aimed to identify specific differentially expressed miRNAs and their overlapping miRNA expression profiles in schizophrenia (SZ), major depression disorder (MDD), and bipolar disorder (BD), the three major PDs.MethodsThe literatures up to September 30, 2023 related to peripheral blood miRNAs and PDs were searched and screened from multiple databases. The differences in miRNA levels between groups were illustrated by the standardized mean difference (SMD) and 95% confidence interval (95% CI).ResultsIn total, 30 peripheral blood miRNAs were included in the meta-analysis, including 16 for SZ, 12 for MDD, and 2 for BD, each was reported in more than 3 independent studies. Compared with the control group, miR-181b-5p, miR-34a-5p, miR-195-5p, miR-30e-5p, miR-7-5p, miR-132-3p, miR-212-3p, miR-206, miR-92a-3p and miR-137-3p were upregulated in SZ, while miR-134-5p, miR-107 and miR-99b-5p were downregulated. In MDD, miR-124-3p, miR-132-3p, miR-139-5p, miR-182-5p, miR-221-3p, miR-34a-5p and miR-93-5p were upregulated, while miR-144-5p and miR-135a-5p were downregulated. However, we failed to identify statistically differentially expressed miRNAs in BD. Interestingly, miR-132-3p and miR-34a-5p were upregulated in both SZ and MDD.ConclusionsOur study identified 13 differentially expressed miRNAs in SZ and 9 in MDD, among which miR-132-3p and miR-34a-5p were upregulated in both SZ and MDD by systematically analyzing qualified studies. These miRNAs may be used as potential biomarkers for the diagnosis of SZ and MDD in the future.Systematic Review Registrationhttp://www.crd.york.ac.uk/PROSPERO, identifier CRD42023486982.
Causal effects of 731 immune cell phenotypes on autism spectrum disorder: a Mendelian randomization study
Authors: Yu Yunfeng , Yang Xinyu , Hu Gang , Yin Yuman , Yu Rong 
Published: May 2024

ObjectiveThe role of different immune cells in autism spectrum disorders (ASD) is still controversial. The purpose of this study was to evaluate the causal effects of different immune cell phenotypes on ASD via Mendelian randomization (MR).MethodsDatasets of immune cell phenotypes were obtained from the European Bioinformatics Institute, and datasets of ASD were obtained from the IEU Open GWAS project. Single nucleotide polymorphisms were selected based on the assumptions of association, independence, and exclusivity. Inverse variance weighted was utilized as the main method for MR analysis. MR-Egger was employed to assess the horizontal pleiotropy of the results. Cochran’s Q and leave-one-out method were used for heterogeneity analysis and sensitivity analysis of the results, respectively.ResultsMR analysis showed that TD CD8br AC [odds ratio (OR), 1.137; 95% confidence interval (CI), 1.031–1.254; p = 0.010], CD8br %leukocyte (OR, 1.142; 95% CI, 1.067–1.223; p &lt; 0.001), CD8br and CD8dim %leukocyte (OR, 1.117; 95% CI, 1.032–1.210; p = 0.006), naive CD8br %T cell (OR, 1.052; 95% CI, 1.004–1.104; p = 0.035), CD28− CD8dim %T cell (OR, 1.097; 95% CI, 1.038–1.158; p &lt; 0.001), CD127− CD8br AC (OR, 1.086; 95% CI, 1.006–1.171; p = 0.034), CD45 on CD8br (OR, 1.059; 95% CI, 1.021–1.099; p = 0.002), CD3 on HLA DR+ CD8br (OR, 1.098; 95% CI, 1.041–1.158; p &lt; 0.001), CD4 on activated Treg (OR, 1.048; 95% CI, 1.001–1.096; p = 0.046), CD3 on CD39+ resting Treg (OR, 1.070; 95% CI, 1.012–1.131; p = 0.018), IgD+ CD38− %lymphocyte (OR, 1.103; 95% CI, 1.023–1.190; p = 0.011), CD62L− plasmacytoid DC %DC (OR, 1.046; 95% CI, 1.001–1.093; p = 0.046), and FSC-A on plasmacytoid DC (OR, 1.075; 95% CI, 1.003–1.153; p = 0.042) were associated with increased genetic susceptibility to ASD. MR-Egger displayed no horizontal pleiotropy (p ≥ 0.05). Cochran’s Q revealed no heterogeneity of results (p ≥ 0.05). Sensitivity analysis indicated that the results were robust.ConclusionThis MR analysis revealed 13 immune cell phenotypes associated with increased genetic susceptibility to ASD and emphasized the importance of CD8 T cells and Tregs, which provides new directions for the pathogenesis and drug research of ASD.
The role of school climate on student disclosure of private information and cyberbullying: a comparison of regular and vocational school students in China
Authors: Chen Qiqi , Tang Jiaqi , Zhu Yuhong , Chan Ko Ling 
Published: May 2024

IntroductionAdolescents are experiencing an unprecedented cyber-saturated environment where the disclosure of private information should be approached with caution. This study aims to investigate the effects of school environment, including student support, teacher support, and opportunities for autonomy, on students’ disclosure of private information and their experiences with cyberbullying.MethodsIn September 2022, a total of 1,716 students (mean age = 14.60, SD = 1.35) from three regular and vocational schools in China participated in the survey.ResultsThe results showed that 35.6% of the participants had experienced victimization by cyberbullying, and 12.6% had perpetrated cyberbullying. Vocational school students reported significantly higher rates of cyberbullying and lower levels of perceived school climate than students from regular school. Student support in the school environment was found to negatively affect both cyberbullying perpetration and victimization, with this impact appearing to be stronger in regular schools as compared to vocational schools. Opportunities for autonomy and the disclosure of private information were positively correlated with experiences of cyberbullying.DiscussionThis study introduces a novel perspective that perceived school climate influences adolescents’ disclosure of private information and their involvement in cyberbullying. The findings could provide implications for future research and practices aimed at child protection in cyberspace.
Perancangan Sistem Informasi Penjualan Online Pada Leonheart Cell Jambi
Authors: Willis Indra Sakti , Amroni Amroni , Andrianti Ari 
Published: May 2024

Leonheart Cell Jambi adalah usaha yang bergerak di bidang penjualan handphone dan aksesoris dimana proses promosi dan penjualan sedang memakai teknik manual. Maka terjadilah permasalahan dimana sulitnya meningkatkan omzet penjualan dalam jumlah yang besar, kurangnya sarana promosi yang dapat dilakukan dengan biaya murah, dan kurangnya sarana pemberian informasi produk yang ditawarkan. Penelitian yang dilakukan ini bermaksud merancang sistem informasi penjualan online. Penelitian ini memakai bahasa pemograman PHP, DBMS MySQL dan metode pengembangan sistem waterfall. Penelitian yang dilakukan ini terdapat beberapa tahapan yaitu identifikasi masalah, studi literatur ,pengumpulan data, desain sistem, pengembangan sistem dan pembuatan laporan. Pencapaian penelitian memberikan kemudahan pada Leonheart Cell Jambi dalam promosi dengan biaya murah, memperluas wilayah promosi dan penjualan yang dapat meningkat tanpa harus menunggu pelanggan datang ke tempat.
Some Indicators of Platelet Aggregation in Patients with Multivessel Coronary Disease on the Background of Diabetes Mellitus
Authors: Якуббеков Н.Т. , Никишин А.Г. , Муллабаева Г.У. , Абдуллаева С.Я. , Узоков Ж.К. 
Published: May 2024

Цель. Изучить взаимосвязь агрегационных свойств крови у пациентов с СД второго типа и многососудистым поражением коронарных артерий с длительностью заболевания, уровнем гликемии, формами ИБС. Материалы и методы. В данном исследовании проанализированы результаты данных агрегации у 122 пациентов с многососудистым поражением коронарного русла, среди которых 67 мужчин, 55 женщин (средний возраст составил 61,83±19,5 года). Пациенты были разделены на 2 группы – с наличием сахарного диабета и без сахарного диабета, и была проведена агрегация тромбоцитов. Результаты. Изучение особенностей антиагрегантной терапии у пациентов с сахарным диабетом продемонстрировало достоверно выраженную АДФ-индуцированную скорость и степень агрегации по сравнению с группой пациентов без сахарного диабета (P<0,05). Группа пациентов с СД и нестабильными формами ИБС имела достоверно более высокие показатели спонтанной и адреналин-индуцированной скорости агрегации тромбоцитов, нежели группа со стабильной ИБС (P<0,05). Выводы. Выявлена взаимосвязь между уровнем гликированного гемоглобина выше 7% и скоростью спонтанной и коллаген-индуцированной агрегации тромбоцитов.
Purpose. To study the relationship of blood aggregation properties in patients with type 2 diabetes and multivessel coronary artery disease with the duration of the disease, glycemia level, forms of coronary artery disease. Materials and methods. This study analyzed the results of aggregation data in 122 patients with multivessel coronary disease, including 67 men, 55 women (mean age was 61.83±19.5 years). Divided into 2 groups with the presence of diabetes and without diabetes, and platelet aggregation was carried out. Results. Thus, the study of the features of antiplatelet therapy in patients with diabetes mellitus demonstrated a significantly pronounced ADP-induced rate and degree of aggregation compared with the group of patients without diabetes mellitus (P<0.05). The group of patients with DM and unstable forms of CAD had significantly higher rates of spontaneous and adrenaline-induced platelet aggregation rate than the group with stable CAD (P<0.05). Conclusion. A relationship was found between the level of glycated hemoglobin above 7% and the rate of spontaneous and collagen-induced platelet aggregation.
Aktualisasi Land untuk Tanaman Jahe Gajah (zingiber officinale rosc) di Kecamatan Libureng Kabupaten Bone
Authors: Zhiddiq Sulaiman , Nismawati Nismawati , Yusuf Muhammad , Mannan Abd. , Juanda Faisal 
Published: May 2024

Penelitian bertujuan untuk mengetahui luasan tingkat kesesuaian lahan aktual tanaman jahe gajah (zingebel officinale rosc). Ditemutunjukkan melalui evaluasi kesesuaian lahan dengan pendekatan satuanlahan (tumpangsusun peta penggunaan lahan, peta tanah, peta lereng, dan peta bentuklahan) menggunakan metode stratified random sample. Pengambilan contoh tanah dititik sampel, analisis data menggunakan metode matching. Hasil penelitian menunjukkan bahwa karakteristik lahan bervariasi, beriklim basah; suhu udara berada pada 26,6°C; ketersediaan air sedang; media perakaran untuk drainase tanah mulai dari baik-agak terhambat; tekstur tanah dari lempung berdebu sampai liat; kedalaman efektif sedang sampai dalam; retensi hara untuk KTK tanah sedang sampai tinggi; pH tanah dari sangat asam sampai asam; kejenuhan basa dari 26 sampai 30; C-Organik sangat rendah-sedang; hara tersedia P2O5 (P tersedia) sedang sampai tinggi; K2O rendah sampai sedang; N-total 0,07 sampai 0,12% (rendah); potensi mekanismee untuk lereng dari datar, landai, agak landai, curam dan sangat curam; singkapan batuan tidak ada sampai sedang; batuan permukaan mulai dari tidak ada hingga banyak; dan bahaya erosi dari tidak ada sampai ada. Kesesuaian lahan tanaman Jahe Gajah berada pada kelas kesesuaian lahan ada 4 sangat sesuai (S1), cukup sesuai (S2), sesuai marginal (S3). Agihan kesesuaian lahan untuk tanaman Jahe Gajah di Kecamatan Libureng diperoleh bahwa kesesuaian lahan S1 luasan lahan 4061,92 Ha. Kelas S2 (cukup sesuai) luasan lahan 23174,14 Ha. S3 (sesuai marginal) luasan lahan 5315,54Ha
Heat transfer study of 3D packaging structure with superconducting TSV for practical-scale quantum annealing machines
Authors: Feng Wei , Kikuchi Katsuya 
Published: May 2024

Abstract
To avoid the interconnect crowding in a planar structure, three-dimensional (3D) integrated technologies are necessary for realizing practical large-scale quantum annealing (QA) machines. We studied the heat transfer of a 3D packaging structure with superconducting through-silicon via for large-scale QA machines by finite element method simulation. The heat transfer becomes less efficient in the stacked structure. A high temperature of 57.0 mK is observed for the qubit chip, which degrades the quantum coherence of the qubit chip. We propose a heat transfer optimization method by increasing the number of bumps under the active interposer. Furthermore, by shortening the distance to the heat sink, the maximum temperature of the qubit chip is reduced to 18.1 mK. Our proposed heat transfer optimization methods are useful to provide a cryogenic temperature for stable qubit chip operation in a 3D packaging structure to realize practical-scale superconducting QA machines.
EXPLORING ARTS-BASED METHODS IN UNPAID CAREGIVING CONTEXTS: A SCOPING REVIEW
Authors: Dupuis Constance , Sethi Bharati , Williams Allison 
Published: May 2024

Introduction:Unpaid caregiving plays a crucial role in supporting older adults, requiring innovative approaches to understand and enhance caregivers' experiences. Research Objectives: As a response, this scoping review investigates the application of arts-based methods in understanding the caregiving experience, as well as the advantages and limitations of these methods in providing care to diverse populations. Methodology: Building on Arksey and O’Malley's framework, our methodology draws from the Joanna Briggs Institute approach. Eligibility criteria encompassed peer-reviewed publications in English from 2007 to 2022, focusing on unpaid caregivers, arts-based methods, and caregiving experiences. Six comprehensive databases were queried, with the initial searches yielding 761 articles. Full text screening of 66 papers resulted in 19 papers for inclusion in the scoping review. Results: Analysis of the literature revealed the multifaceted applications of arts-based methods in understanding and supporting unpaid caregivers. These encompassed a wide range of creative techniques, such as visual arts, photo elicitation, storytelling, and performance – which provided insights into the emotional, psychological, and social dimensions of caregiving. Findings highlighted the potential for arts-based methods to enhance caregiver well-being, foster self-reflection and self-care, and promote dialogue. Nonetheless, there were notable gaps. Racial and ethnic diversity was often neglected in the studies (addressed in 3 of 19), underscoring the necessity for tailored interventions and methodological considerations for diverse populations. Importantly, dementia caregiving received substantial attention (12 of 19). Final Considerations: This scoping review highlights the growing interest in integrating arts-based methods into caregiving research and interventions amongst qualitative and mixed methods approaches. By mapping out the landscape of existing literature, this review underscores the need for further exploration and methodological refinement to harness the full potential of creative techniques in advancing our understanding of unpaid caregivers' lived experiences. Arts-based approaches hold promise in providing a nuanced and holistic perspective on unpaid caregiving experiences.
Crime organizado e Ministério Público: o combate e a repercussão para efetivação de direitos fundamentais
Authors: José do Carmo Neto Renério 
Published: May 2024

Trata o presente artigo da análise do crime organizado, sua forma de atuação, formação e consequência direta para vida em sociedade, bem como da atuação do Ministério Público no combate à criminalidade organizada, sendo apresentados suas limitações, campo de alcance e estrutura, repercutindo na efetivação de direitos fundamentais, sobretudo aos menos favorecidos, proporcionando maior acesso à educação, saúde, segurança, transporte, cultura, entre outros. Fez-se uso da pesquisa aplicada, com âmbito qualitativo, buscando a compreensão de um fenômeno e, no que se refere às técnicas, foi feita a análise de documentação indireta, abrangendo a pesquisa documental e bibliográfica, com o estudo de caso envolvendo a matéria, além de dispositivos e normas legais. Inicialmente, apresentam-se o conceito, as características e o tratamento dado pelo ordenamento jurídico ao crime organizado, em sequência é exposta uma das principais classificações doutrinárias que diferenciam os atores dos ilícitos. A atuação do órgão ministerial é apresentada no tópico seguinte, em que são expostas suas limitações, organização e formas de atuação. Em seguida, o terceiro tópico versa sobre os direitos fundamentais, conceito, classificação e previsão legal, seguido pela repercussão direta que a repressão às organizações criminosas causa na efetivação dos direitos fundamentais, tendo enfoque específico na atuação do Parquet. Conclui-se que não basta a criação ou o endurecimento de tipos penais, se os crimes já existentes não são combatidos de forma eficaz. Sabe-se que a criminalidade organizada está há anos luz dos órgãos de fiscalização e investigação, entretanto cabe ao Estado equipar quem a combate e adotar medidas.
Considerações sobre a impossibilidade jurídica da acareação de crianças e adolescentes vítimas ou testemunhas de violência
Authors: Oliveira Heitor Moreira de , Dias Paulo Cezar 
Published: May 2024

O presente estudo dialoga com o artigo publicado na 9ª edição da Revista do CNMP, que versou sobre a impossibilidade da condução coercitiva de criança e adolescente, vítima ou testemunha de violência, no processo penal brasileiro. Na mesma trilha, objetiva-se demonstrar que, à luz do sistema de garantia de direitos da criança e do adolescente vítima ou testemunha de violência e dos comandos da Lei nº 13.431/2017, notadamente os artigos 9º e 12, § 3º, a par de não ser possível a condução coercitiva, igualmente também não se admite a acareação com o suposto agressor, sob pena de se caracterizar inaceitável revitimização advinda de odiosa violência institucional. Emprega-se o método hipotético-dedutivo e, ao final, conclui-se que a impossibilidade de acareação é mais uma regra de adaptação procedimental que permite o exercício do direito de participação de crianças e adolescentes, mas as coloca a salvo de sofrimento no curso do processo
Penerapan Teknologi Gasifikasi Pada UMKM “Tahu” di Desa Juglangan Kecamatan Panji Kabupaten Situbondo
Authors: Surjadi Eko , Suryaningsih Yasmini , Yekti Gema Iftitah Anugerah 
Published: May 2024

Kegiatan pengabdian pada masyarakat dilakukan di industri pembuatan tahu tradisional “bu Irma” milik Ibu Irmawati yang berlokasi di Desa Juglangan Kecamatan Panji Kabupaten Situbondo. Industri pembuatan tahu oleh mitra masih dilakukan secara tradisional dengan alat alat yang masih sederhana yaitu tungku dan bak pemasakan yang menempel pada tungku serta alat cetak sederhana. Hal tersebut menebabkan penggunaan biaya produksi yang tinggi untuk pemenuhan bahan bakar kayu atau tongkol jagung dan yang menyebabkan kualitas dan kuantitas produk tahu tidak maksimal yang diikuti pendapatan yang juga tidak bisa maksimal serta pencatatan keuangannya yang masih menghitung belanja dan omzet yang didapatkan saja. Solusi yang ditawarkan kepada mitra adalah mencakup bidang produksi dan manajemen keuangan. Bidang produksi antara lain a) meminimalkan biaya bahan bakar dalam proses produksi usaha pembuatan tahu . (b) memperbaiki kualitas dan kuantitas produk tahu i. Tujuan dari kegiatan pengabdian masyarakat melalui program kemitraan pada masyarakat ini adalah untuk membantu penyelesaian permasalahan prioritas mitra agar mitra mampu meningkatkan pendapatan industri tahu, memberdayakan hasil penelitian dosen agar bermanfaat bagi masyarakat dan memberikan mahasiswa mendapat pengalaman di luar kampus. Adapun hasil pengabdian kepada masyarakat adalah pengadaan tungku berteknologi gasifikasi dengan sekam padi sebagai umpan, pengadaan bak pemasakan bubur kedelai yang mudah dibersihkan dan alat tabung steam untuka proses pemasakan.