bluuebunny/crossref_metadata_2025_split huggingface dataset:
Symptoms of Depression Predict the Trajectory of Pain Among Patients with Early Inflammatory Arthritis: A Path Analysis Approach to Assessing Change
Authors: SCHIEIR ORIT , THOMBS BRETT D. , HUDSON MARIE , TAILLEFER SUZANNE , STEELE RUSSELL , BERKSON LAEORA , BERTRAND CAROLE , COUTURE FRANCOIS , FITZCHARLES MARY-ANN , GAGNÉ MICHEL , GARFIELD BRUCE , GUTKOWSKI ANDRZEJ , KANG HARB , KAPUSTA MORTON , LIGIER SOPHIE , MATHIEU JEAN-PIERRE , MÉNARD HENRI , MERCILLE SUZANNE , STARR MICHAEL , STEIN MICHAEL , ZUMMER MICHEL , BARON MURRAY 
Published: May 2009

Objective.To assess the longitudinal relationships, including directionality, among chronic pain, symptoms of depression, and disease activity in patients with early inflammatory arthritis (EIA).Methods.One hundred eighty patients with EIA completed an examination, including swollen joint count, and were administered the Center for Epidemiological Studies Depression Scale (CES-D) and the McGill Pain Questionnaire (MPQ) at 2 timepoints 6 months apart. Cross-lagged panel path analysis was used to simultaneously assess concurrent and longitudinal relationships among pain, symptoms of depression, and number of swollen joints.Results.Pain, symptoms of depression, and number of swollen joints decreased over time (p < 0.001) and were prospectively linked to pain, symptoms of depression, and number of swollen joints, respectively, at 6 months. Symptoms of depression and pain were correlated with each other at baseline (0.47) and at 6-month followup assessments (0.28). Baseline symptoms of depression significantly predicted pain symptoms at 6 months (standardized regression coefficient = 0.28, p = 0.001), whereas pain and disease activity did not predict the course of any other variable after controlling for baseline values.Conclusion.Symptoms of depression predicted the trajectory of pain from baseline to 6 months. In addition, there were reciprocal/bidirectional associations between pain and symptoms of depression over time. More research is needed to better understand the relationship between pain and depressive symptoms and how to best manage patients with EIA who have high levels of both.
Dendritic Cells Contribute to Autoimmune Kidney Injury in MRL-Faslpr Mice
Authors: IWATA YASUNORI , FURUICHI KENGO , SAKAI NORIHIKO , YAMAUCHI HIROYUKI , SHINOZAKI YASUYUKI , ZHOU HAIYAN , KUROKAWA YUKIE , TOYAMA TADASHI , KITAJIMA SHINJI , OKUMURA TOSHIYA , YAMADA SHINGO , MARUYAMA IKURO , MATSUSHIMA KOUJI , KANEKO SHUICHI , WADA TAKASHI 
Published: May 2009

Objective.Dendritic cells (DC) contribute to autoimmune disease progression and pathogenesis. Mature DC have been reported to secrete high mobility group box protein (HMGB-1), a novel inflammatory cytokine, via p38 mitogen-activated protein kinase (MAPK) activation. We investigated whether DC are involved in progression of autoimmune diseases followed by secretion of HMGB-1 via p38 MAPK activation in a lupus-prone mouse model.Methods.FR167653, a specific inhibitor of p38 MAPK, was given orally from 3 months of age in MRL-Faslpr mice. Cultured DC, treated with or without FR167653, were stimulated with tumor necrosis factor-α.Results.Inhibition of p38 MAPK led to a reduction in the number of CD11c-positive cells, including those with the mature phenotype, in the diseased kidney and spleen, which resulted in improvement of kidney pathology in MRL-Faslpr mice. The number of CD11c-positive cells in circulation was also reduced. HMGB-1 protein and transcripts detected in the diseased kidney, and the number of cells dual-positive for HMGB-1 and CD11c, were reduced by inhibition of p38 MAPK. Maturation of cultured DC and increased cytokines, including HMGB-1, in the supernatant were inhibited by FR167653 treatment. These results suggest that DC are involved in the progression of autoimmune kidney diseases in MRL-Faslpr mice followed by HMGB-1 secretion via p38 MAPK activation.Conclusion.Our results indicated that DC secrete HMGB-1 via p38 MAPK activation to participate in autoimmunity in MRL-Faslpr mice.
Cementoplasty in the Treatment of Avascular Necrosis of the Hip
Authors: REUTER NICOLAS , ROMIER ALBAN , HAMBOURG ZEPHIR , PALMIERI FRÉDÉRIC , FAYET DOMINIQUE , PALLOT-PRADES BÉATRICE , COLLET PHILIPPE , FESSY MICHEL-HENRY , FARIZON FRÉDÉRIC , BARRAL FABRICE G. , THOMAS THIERRY 
Published: May 2009

Objective.This retrospective study evaluated the role of percutaneous cementoplasty in the treatment of avascular necrosis (AVN) of the hip in order to postpone or avoid total hip replacement.Methods.The study population comprised 40 patients (47 hips) with mean age of 46 ± 4.7 years and mean body mass index of 26.7 ± 4.6 kg/m2. AVN was classified according to the Ficat-Arlet classification as one stage I, 30 stage II, and 16 stage III. The minimum followup was 9 months.Results.It was found that 74.5% of hips were secondarily operated for total hip replacement a mean of 19.9 ± 15 months (median 14 mo) after cementoplasty. As well, 94% of patients with stage 3AVN and 68% with stage 2AVN underwent surgery. Twelve hips were not operated, with a mean followup of 39 ± 19.2 months. Pain decreased by more than 80% after cementoplasty in two-thirds of patients, but the mean pain-free interval was only 8.1 ± 6.6 months (median 5 mo). Nineteen of the 29 working patients were able to transiently return to work. The outcome was more unfavorable with radiological stage III AVN, joint effusion, and/or a double-line sign around the lesions on magnetic resonance images.Conclusion.Despite early relief of pain, the results of the cementoplasty technique were disappointing, with need for arthroplasty surgery in most cases within 2 years. Alternative percutaneous techniques using different filler materials with osteoinductive properties should be evaluated in further studies.
Limitations to the 6-Minute Walk Test in Interstitial Lung Disease and Pulmonary Hypertension in Scleroderma
Authors: GARIN MARGARET C. , HIGHLAND KRISTIN B. , SILVER RICHARD M. , STRANGE CHARLIE 
Published: May 2009

Objective.To determine factors that influence 6-minute walk distance (6MWD) in patients with scleroderma (systemic sclerosis, SSc)-interstitial lung disease (ILD), SSc-pulmonary hypertension (PH), and idiopathic pulmonary fibrosis (IPF).Methods.We retrospectively evaluated all patients with SSc or IPF who performed a 6-minute walk test (6MWT) at a university hospital between 1999 and 2003. Chi-square, ANOVA, simple linear regression, and backwards elimination multivariable regressions were performed.Results.Forty-eight consecutive IPF patients with 6MWT were compared to 33 patients with SSc-ILD, 13 with SSc-PH, 19 with both SSc-ILD and SSc-PH (SSc-Both), and 15 with SSc without ILD or PH (SSc-Neither). Mean 6MWD did not differ between groups. Limitations to 6MWT trended toward dyspnea in IPF and lower extremity pain in SSc. SSc-Both had dyspnea limitation more than other SSc subgroups (p = 0.017). Percentage predicted forced vital capacity (FVC%) and percentage predicted carbon monoxide diffusing capacity (DLCO%) were more strongly predictive of 6MWD in IPF than in SSc; however, exclusion of SSc subjects with pain limitation improved the predictive value. Significant correlates of 6MWD in multivariable analysis differed between subgroups.Conclusion.Pain limitations confound the utility of the 6MWT, particularly in SSc. Pain may cause failure to reach a dyspnea limitation during 6MWT, especially in SSc patients without both ILD and PH. Correlates of 6MWD differ between SSc subgroups and IPF; therefore, the 6MWT distance is not always reflective of the same physiological process. 6MWT interpretation should include consideration of vascular, pulmonary, and musculoskeletal exercise limitations.
Pulmonary Tuberculosis and Disease-Related Pulmonary Apical Fibrosis in Ankylosing Spondylitis
Authors: HO HUEI-HUANG , LIN MENG-CHIH , YU KUANG-HUI , WANG CHIN-MAN , WU YEONG-JIAN JAN , CHEN JI-YIH 
Published: May 2009

Objective.We investigated the etiological association and clinical characteristics of apical pulmonary fibrosis in ankylosing spondylitis (AS).Methods.We reviewed medical records of 2136 consecutive patients diagnosed with AS at a tertiary medical center. Clinical and radiographic characteristics were analyzed for evidence of apical lung fibrosis on chest radiographs.Results.Of 2136 patients with AS, 63 (2.9%) developed apical lung fibrosis, of which chronic infections were the cause in 41 and AS inflammation predisposed the fibrosis in 22 patients. Tuberculosis (TB) infection was considered to be the cause of apical lung fibrosis in 40 patients (63.5%) including 19 with bacteriologically-proven TB and 21 with chest radiographs suggestive of TB. Two were identified as having non-TB mycobacterial infection and one asAspergillusinfection. Lung cavity lesion appeared to be a crucial differentiator (p = 0.009, odds ratio 7.4, 95% CI 1.5–36.0) between TB infection and AS inflammation-induced apical fibrosis.Conclusion.Our study suggests that TB, instead ofAspergillus, is the most common pulmonary infection in patients with AS presenting with apical lung fibrosis. AS-associated apical lung fibrosis may mimic pulmonary TB infection. Thus, bacteriological survey and serial radiological followup of lung fibrocavitary lesions are critical for accurate diagnosis and treatment.
The Observation of the C–H···O Hydrogen Bond in Trisialic Acid Lactone and Its Implications for Cooperative Lactonization
Authors: Chen Chien‐Sheng , Yu Yi‐Ping , Lin Bo‐Chao , Gervay‐Hague Jacquelyn , Fang Jim‐Min , Hsu Chao‐Ping , Wu Shih‐Hsiung 
Published: May 2009

AbstractThe C–H···O hydrogen bond in trisialic acid lactones has been examined by using long‐range COSY (LRCOSY) and ab initio calculations. From an analysis of the LRCOSY spectra, 3J correlations of BH9ax/AH8 and CH9ax/BH8 confirmed the existence of hydrogen‐bond connections of x+1C9–x+1H9ax···xO8. The theoretical bond energy of the hydrogen bond was estimated to be 1.0 or 1.6 kcal/mol by using two models. The acid‐catalyzed cooperative lactonization of oligosialic acids can be understood in terms of the additional C–H···O stabilization in the lactone product. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2009)
Cultivating the Passion to Build Heterocycles from 1,2‐Diaza‐1,3‐dienes: the Force of Imagination
Authors: Attanasi Orazio A. , De Crescentini Lucia , Favi Gianfranco , Filippone Paolino , Mantellini Fabio , Perrulli Francesca R. , Santeusanio Stefania 
Published: May 2009

AbstractThe present microreview summarizes our progresses over the last years in the chemistry of 1,2‐diaza‐1,3‐dienes. Beyond the findings reported here, the main target of this microreview is to outline some of the reactive peculiarities that make this class of compounds powerful tools in heterocyclic chemistry. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2009)
Synthesis of Calystegine A3 from Glucose by the Use of Ring‐Closing Metathesis
Authors: Monrad Rune Nygaard , Pipper Charlotte Bressen , Madsen Robert 
Published: May 2009

AbstractA synthesis of the nortropane alkaloid calystegine A3 is described from D‐glucose. The key step employs a zinc‐mediated tandem reaction where a benzyl‐protected methyl 6‐iodo glucoside is fragmented to give an unsaturated aldehyde, which is then transformed into the corresponding benzylimine and allylated in the same pot. The functionalized nona‐1,8‐diene, thus obtained, is converted into the seven‐membered carbon skeleton in calystegine A3 by ring‐closing olefin metathesis. Subsequent deoxygenation by the Barton–McCombie protocol, hydroboration and oxidative workup followed by hydrogenolysis affords calystegine A3. The synthesis uses a total of 13 steps from glucose and confirms the absolute configuration of the natural product.(© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2009)
Lipase‐Catalyzed Regioselective One‐Step Synthesis of Penta‐O‐acetyl‐3‐hydroxylactal
Authors: Filice Marco , Vanna Renzo , Terreni Marco , Guisan Jose M. , Palomo Jose M. 
Published: May 2009

AbstractA highly efficient regioselective enzymatic preparation ofpenta‐O‐acetyl‐1,5‐anhydro‐2‐deoxy‐3‐hydroxy‐4‐O‐β‐galactopyranosyl‐D‐arabinohex‐1‐enitol has been successfully performed for the first time. This product was obtained in >99 % conversion (>95 % overall yield) by hydrolysis of per‐O‐acetylated lactal catalyzed by the lipase from Rhizomucor miehei immobilized on octylagarose. This molecule could be a potential building block for efficient synthesis of oligosaccharides or glycoconjugates.(© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2009)
Influence of reaction mechanisms, grid spacing, and inflow conditions on the numerical simulation of lifted supersonic flames
Authors: Gerlinger P. , Nold K. , Aigner M. 
Published: May 2009

AbstractThe simulation of supersonic combustion requires finite‐rate chemistry because chemical and fluid mechanical time scales may be of the same order of magnitude. The size of the chosen reaction mechanism (number of species and reactions involved) has a strong influence on the computational time and thus should be chosen carefully. This paper investigates several hydrogen/air reaction mechanisms frequently used in supersonic combustion. It is shown that at low flight Mach numbers of a supersonic combustion ramjet (scramjet), some kinetic schemes can cause highly erroneous results. Moreover, extremely fine computational grids are required in the lift‐off region of supersonic flames to obtain grid‐independent solutions. The fully turbulent Mach 2 combustion experiment of Cheng et al. (Comb. Flame 1994; 99: 157–173) is chosen to investigate the influences of different reaction mechanisms, grid spacing, and inflow conditions (contaminations caused by precombustion). A detailed analysis of the experiment will be given and errors of previous simulations are identified. Thus, the paper provides important information for an accurate simulation of the Cheng et al. experiment. The importance of this experiment results from the fact that it is the only supersonic combustion test case where temperature and species fluctuations have been measured simultaneously. Such data are needed for the validation of probability density function methods. Copyright © 2009 John Wiley & Sons, Ltd.
13C‐NMR spectra of santalol derivatives: a comparison of DFT‐based calculations and database‐oriented prediction techniques
Authors: Stappen Iris , Buchbauer Gerhard , Robien Wolfgang , Wolschann Peter 
Published: May 2009

AbstractA systematic investigation of a series of santalol and epi‐santalol derivatives by means of ab initio and density functional theory (DFT) calculations together with database‐oriented prediction methods leads to a configurational reassignment within this compound class. The DFT calculations as well as the HOSE‐code and neural network‐based predictions allow deriving a general rule set for unambiguous assignment within this compound class. The methyl group in position 2′ serves as an indication for the configuration at this stereocenter allowing easy differentiation between santalol derivatives and their diastereomers belonging to the epi‐santalol series. Copyright © 2009 John Wiley & Sons, Ltd.
1H, 13C and 15N NMR spectral assignments for new triazapentalene derivatives
Authors: Palmas Pascal , Nyffenegger Coralie , Pasquinet Eric , Guillaumet Gérald 
Published: May 2009

AbstractMesomeric heteropentalene betaines are conjugated fused polyheterocyclic structures that represent interesting intermediates for organic synthesis. Five such structures, containing at least four nitrogen atoms and various substituents, have been characterized by 1H, 13C and 15N NMR. We report, apparently for the first time, nitrogen NMR data and coupling information on such systems. Inter‐ring long‐range correlations across five bonds with 15N (5JHN) and up to seven bonds with 13C (6JHC and 7JHC) were observed in HSQC experiments. The incorporation of an electron‐withdrawing substituent such as NO2 was observed to cause an increase in the magnitude of the remote couplings and deshielding of nearby protons, carbons and on all nitrogen atoms of the structure, including remote ones situated on other cycles. Copyright © 2009 John Wiley & Sons, Ltd.
Fabrication of poly(ethylene glycol)‐based hydrogels entrapping enzyme‐immobilized silica nanoparticles
Authors: Jang Eunji , Park Saemi , Park Sangphil , Lee Yeol , Kim Dae‐Nyun , Kim Bumsang , Koh Won‐Gun 
Published: May 2009

AbstractIn this study, we immobilized enzymes by combining covalent surface immobilization and hydrogel entrapment. A model enzyme, glucose oxidase (GOX), was first covalently immobilized on the surface of silica nanoparticles (SNPs) via 3‐aminopropyltriethoxysilane (APTES), and the resultant SNP‐immobilized enzyme was physically entrapped within photopolymerized hydrogels prepared from two different molecular weights (MWs) (575 and 8000 Da) of poly(ethylene glycol)(PEG). The hydrogel entrapment resulted in a decrease in reaction rate and an increase in apparent Km of SNP‐immobilized GOX, but these negative effects could be minimized by using hydrogel with a higher MW PEG, which provides higher water content and larger mesh size. The catalytic rate of the PEG 8000 hydrogel was about ten times faster than that of the PEG 575 hydrogel because of enhanced mass transfer. Long‐term stability test demonstrated that SNP‐immobilized GOX entrapped within hydrogel maintained more than 60% of its initial activity after a week, whereas non‐entrapped SNP‐immobilized GOX and entrapped GOX without SNP immobilization maintained less than 20% of their initial activity. Incorporation of SNPs into hydrogel enhanced the mechanical strength of the hydrogel six‐fold relative to bare hydrogels. Finally, a hydrogel microarray entrapping SNP‐immobilized GOX was fabricated using photolithography and successfully used for quantitative glucose detection. Copyright © 2009 John Wiley & Sons, Ltd.
Empirical vs natural weighting in random effects meta‐analysis
Authors: Shuster Jonathan J. 
Published: May 2009

AbstractThis article brings into serious question the validity of empirically based weighting in random effects meta‐analysis. These methods treat sample sizes as non‐random, whereas they need to be part of the random effects analysis. It will be demonstrated that empirical weighting risks substantial bias. Two alternate methods are proposed. The first estimates the arithmetic mean of the population of study effect sizes per the classical model for random effects meta‐analysis. We show that anything other than an unweighted mean of study effect sizes will risk serious bias for this targeted parameter. The second method estimates a patient level effect size, something quite different from the first. To prevent inconsistent estimation for this population parameter, the study effect sizes must be weighted in proportion to their total sample sizes for the trial. The two approaches will be presented for a meta‐analysis of a nasal decongestant, while at the same time will produce counter‐intuitive results for the DerSimonian–Laird approach, the most popular empirically based weighted method. It is concluded that all past publications based on empirically weighted random effects meta‐analysis should be revisited to see if the qualitative conclusions hold up under the methods proposed herein. It is also recommended that empirically based weighted random effects meta‐analysis not be used in the future, unless strong cautions about the assumptions underlying these analyses are stated, and at a minimum, some form of secondary analysis based on the principles set forth in this article be provided to supplement the primary analysis. Copyright © 2009 John Wiley & Sons, Ltd.
Reaction Pathways in the Formation of Intermetallic InPd3 Polymorphs
Authors: Kohlmann Holger , Ritter Clemens 
Published: May 2009

AbstractThe atomic order in InPd3 was determined by neutron powder diffraction on a series of samples synthesized under various conditions. While annealing at temperature T ≥ 800 K yields a fourfold superstructure of a cubic closest packing (ccp) of the ZrAl3 type (space group I4/mmm (No. 139), a = 406.196(5) pm, c = 1520.31(2) pm, Z = 4), short reaction times at T ≤ 750 K produce InPd3 in a twofold ccp superstructure of the TiAl3 type (space group I4/mmm (No. 139), a = 409.96(2) pm, c = 747.59(5) pm, Z = 2). Crystallographic group‐subgroup relationships in terms of a Bärnighausen symmetry tree for a series of ccp superstructures reveal the simple formula n = 2m·3p for the domain size n, indicating the number of like layers in the stacking sequence An Bn, where m and p are the number of e2 and e3 transitions within the space group types P4/mmm and I4/mmm, respectively. From the factors governing the appearance and structural details of ccp superstructures atomic size seems to play a major role in determining the c/a ratio in MPd3 compounds with M being a main group metal. Thermal analysis, X‐ray and neutron powder diffraction suggest that the formation of InPd3 by an iodine catalyzed reaction starting from the elements procedes by the pathway: In + 3 Pd → 2 (In0.5Pd0.5)Pd [AuCu type] → InPd3 [TiAl3 type] → InPd3 [ZrAl3 type].
The Utility of Genetic Counseling Prior to Offering First Trimester Screening Options
Authors: Hafen L. Brent , Hulinsky Rebecca S. , Ellis Simonsen Sara , Wilder Stephanie , Rose Nancy C. 
Published: May 2009

AbstractIn order to evaluate the utility of genetic counseling at the time of first trimester screening in patients with no previously identified genetic concerns, we reviewed family history data for 700 women seen for genetic counseling in Utah during 2005‐2006. The mean maternal age was 35 years (Range: 16–47 years). The majority of patients seen were non‐Jewish Caucasians (90.8%, 634/700). A three‐generation pedigree was obtained from each woman by one of two certified genetic counselors and subsequently classified as “negative” (no birth defects/genetic disorders); “positive” (birth defect or genetic condition with a minimal/low risk of recurrence; additional evaluation/genetic testing during pregnancy not indicated); or “significant” (birth defect or genetic condition with an increased risk of recurrence; additional evaluation/genetic testing during the pregnancy indicated). About 72% (501/700) of the histories were negative, 19% (134/700) were positive, and about 9% (65/700) were significant. Among patients with significant family histories, 66% (n = 43) were women less than 35 years of age. We conclude that assessing a patient's family history at the time of first trimester serum screening is a valuable resource for pregnancy management.