bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prepectoral Prosthetic Breast Reconstruction Without ADM Using a Subfascial Approach
Authors: Hudson Donald A. 
Published: May 2024

Abstract

Background
Immediate prosthetic reconstruction has evolved to a prepectoral position. A technique is described where the pectoral and serratus fascia is raised from superiorly. Initially, Vicryl mesh was used to close the superior fascial defect, but later abandoned by using primary closure for tissue expanders, or creating a pocket in the infraclavicular pectoralis muscle after prosthesis (DTI) insertion. The inframammary fold is also reinforced. Patients with a BMI > 30 have axillary liposuction.

Method
Retrospective analysis over a 4-year period. Data included age, number of breasts having expanders or DTI. Prosthetic extrusion and follow-up were recorded. The percentage coverage by fascia was calculated.

Results
Forty-seven patients (80 breasts) had mean age of 42 years (range 32–62), twelve patients (19 breasts) had Vicryl mesh inserted, while 35 patients (61 breasts) had closure as noted above. Tissue expanders were inserted in 39 breasts (10 mesh, 29 without). DTI (direct to implant) performed in 41 breasts (32 no mesh, 9 with mesh). Three patients with mesh developed recalcitrant seromas. The mean size of prosthesis used was 353ml (range 200–500 ml). Extrusion occurred in eight breasts (two with mesh, six without). Mean coverage of the prosthesis by fascia was 74% (range 50–100%), and nine patients also had bilateral axillary liposuction of the axillary roll. Mean follow-up was 13 months.

Conclusion
Another technique for immediate prosthetic reconstruction providing an additional layer of prosthetic cover in prepectoral plane, without mesh. Applicable for all grades of ptosis. Extrusion rate is low.

Level of Evidence IV
This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266.
Evaluating postoperative hernia incidence and risk factors following pelvic exenteration
Authors: Milanko Nicole Anais , Kelly Michael Eamon , Turner Greg , Kong Joeseph , Behrenbruch Cori , Mohan Helen , Guerra Glen , Warrier Satish , McCormick Jacob , Heriot Alexander 
Published: May 2024

Abstract
Pelvic exenteration (PE) is a technically challenging surgical procedure. More recently, quality of life and survivorship following PEs are being increasingly acknowledged as important patient outcomes. This includes evaluating major long-term complications such as hernias, defined as the protrusion of internal organs through a facial defect (The PelvEx Collaborative in Br J Surg 109:1251–1263, 2022), for which there is currently limited literature. The aim of this paper is to ascertain the incidence and risk factors for postoperative hernia formation among our PE cohort managed at a quaternary centre.

Method
A retrospective cohort study examining hernia formation following PE for locally advanced rectal carcinoma and locally recurrent rectal carcinoma between June 2010 and August 2022 at a quaternary cancer centre was performed. Baseline data evaluating patient characteristics, surgical techniques and outcomes was collated among a PE cohort of 243 patients. Postoperative hernia incidence was evaluated via independent radiological screening and clinical examination.

Results
A total of 79 patients (32.5%) were identified as having developed a hernia. Expectantly, those undergoing flap reconstruction had a lower incidence of postoperative hernias. Of the 79 patients who developed postoperative hernias, 16.5% reported symptoms with the most common symptom reported being pain. Reintervention was required in 18 patients (23%), all of which were operative.

Conclusion
This study found over one-third of PE patients developed a hernia postoperatively. This paper highlights the importance of careful perioperative planning and optimization of patients to minimize morbidity.
Übersetzung und sprachliche Validierung des modifizierten-Short QUestionnaire to Assess Health-enhancing physical activity (mSQUASH) ins Deutsche für Patienten mit axialer Spondyloarthritis (axSpA)
Authors: Kiefer David , Vaupel Kristina , Kiltz Uta , Hammel Ludwig , van der Kraan Yvonne M. , Arends Suzanne , Baraliakos Xenofon 
Published: May 2024

Zusammenfassung

Hintergrund
Patienten mit axialer Spondyloarthritis (axSpA) leiden oft unter chronischen Schmerzen und entzündlichen Veränderungen, die zu Einschränkungen der körperlichen Funktionsfähigkeit, eingeschränkter Beweglichkeit und verminderter körperlicher Aktivität führen können. Der „Modified-Short QUestionnaire to Assess Health-enhancing physical activity (mSQUASH)“, ein Fragebogen zur Erfassung gesundheitsfördernder körperlicher Aktivität, wurde entwickelt, um die tägliche körperliche Aktivität bei Patienten mit axSpA zu messen.

Ziel
Es erfolgten eine Übersetzung, interkulturelle Anpassung und linguistische Validierung des originalen mSQUASH ins Deutsche für Patienten mit axSpA.

Methoden
Der ursprüngliche mSQUASH-Fragebogen wurde in einem mehrstufigen Prozess (Beaton-Methode) der interkulturellen Anpassung mit Vorwärts-Rückwärts-Übersetzungen vom Niederländischen ins Deutsche durch zweisprachige niederländisch-deutsche Laien und Experten übersetzt. Verbleibende Abweichungen wurden in einer Expertengruppe besprochen, was zu einer vorläufigen deutschen Version führte. Kognitive Befragungen von Patienten mit axSpA mit unterschiedlichen soziodemografischen Hintergründen führten dann zur finalen deutschen Version.

Ergebnisse
Während der Übersetzungen wurden geringfügige Abweichungen hauptsächlich in Bezug auf Formalitäten, semantische Fehler und Syntax festgestellt. Diese wurden angepasst, was zu geringfügigen Änderungen in der Formulierung führte. Die vorläufige deutsche Version wurde durch kognitive Befragungen mit 10 Patienten mit axSpA validiert, wodurch ihre linguistische Validität und Äquivalenz zur niederländischen Version bestätigt wurde.

Diskussion
Insgesamt bestätigte die Untersuchung, dass der finale deutsche mSQUASH ein geeignetes Instrument zur Erfassung der täglichen körperlichen Aktivität ist. Daher kann der vorliegende Fragebogen als Messinstrument in klinischen Studien und in der klinischen Praxis bei deutschsprachigen Patienten mit axSpA eingesetzt werden. Dies kann länderübergreifende Vergleiche ermöglichen und erweitert den Nutzen des Fragebogens über Sprachbarrieren hinweg.
Early-stage hypopharyngeal squamous cell carcinoma treated with radical radiotherapy at a uniform dose of 70 Gy in 35 fractions: a single-center study
Authors: Katano Atsuto , Yamashita Hideomi 
Published: May 2024

Abstract
Introduction
Hypopharyngeal squamous cell carcinoma (HSCC) is often undetected until advanced stages, which contributes to poor survival rates. Recent advances in diagnostic techniques have enhanced the feasibility of early detection, and this study evaluated the efficacy and safety of radical radiotherapy that specifically targets early stage HSCC.

Methods
This retrospective cohort study consecutively analyzed patients with clinical stage I or II HSCC between December 2008 and February 2023. These patients underwent radical radiotherapy with a uniform dose of 70 Gy delivered in 35 fractions to the primary site, followed by elective nodal irradiation. We assessed clinical outcomes, including overall survival (OS), disease-free survival (DFS), and 5-year locoregional control (LRC). Multivariate analyses were performed to identify the independent prognostic factors for OS.

Results
The 5-year OS rate of the entire cohort was 80.7% (95% confidence interval [CI] = 66.5–89.4%), with no significant difference between patients with clinical stage I and II HSCC. Stratified by subsite, the 5-year OS for pyriform sinus, posterior pharyngeal wall, and postcricoid region were 81.6, 68.2, and 100%, respectively. The ECOG-Performance status (PS) was identified as an independent risk factor for OS (hazard ratio [HR] = 8.457; 95% CI 1.325–53.970; p = 0.024). DFS at 5 years was 66.4%, with local recurrence being the most frequent, and LRC rate at 5 years was 79.3%. Acute and late-phase toxicities were predominantly mild to moderate, with no grade 3 or higher toxicities reported.

Conclusion
This study supports radical radiotherapy as an effective approach for optimal tumor control in patients with early stage HSCC. Despite the limitations of this study, including its retrospective design and single-center confinement, our results revealed the effectiveness and feasibility of radical radiotherapy in the management of early stage HSCC.
Neuropsychiatric symptoms and metamemory across the life span: psychometric properties of the German Multifactorial Memory Questionnaire (MMQ)
Authors: Rekers Sophia , Heine Josephine , Thöne-Otto Angelika I. T. , Finke Carsten 
Published: May 2024

Abstract
Objective
We assessed the psychometric properties, established normative data for the German Multifactorial Memory Questionnaire (MMQ), and analyzed its association with neuropsychiatric factors across the life span to provide a validated metamemory assessment for a German-speaking population.

Methods
The three MMQ scales (memory satisfaction, self-rated ability, and strategy application) were translated into German, considering cultural, linguistic, and conceptual aspects. To validate the MMQ and assess associations with neuropsychiatric factors, the Complainer Profile Identification, Geriatric Depression Scale, Beck Anxiety Inventory, Pittsburgh Sleep Quality Index, and Short-Form-Health Survey were applied in an online study in 336 healthy participants with follow-up after 8 months.

Results
Psychometric evaluation of the German MMQ showed normal distribution of all scales and good to excellent validity, internal consistency, and retest reliability. We provide percentiles and normative data for z-score conversion. Importantly, even subclinically elevated scores in depressiveness and anxiety were associated with decreased memory satisfaction and self-rated ability. Furthermore, although the influence of age on the German MMQ scales was minimal, effects of neuropsychiatric factors such as sleep quality, anxiety, and depressiveness on MMQ Satisfaction and Ability varied across the life span.

Conclusions
Our study provides a validated German translation of the MMQ with normative data and reliability measures, including reliable change scores. We show the impact of neuropsychiatric factors on the MMQ scales across the life span and emphasize the relevance of a multifactorial approach to metamemory as a measure of individualized everyday functionality and the importance of including neuropsychiatric factors into both research and clinical assessments of metamemory.
Cardiac output calculation using the Liljestrand and Zander formula: is this method applicable during immediate transition after birth? — A post hoc analysis
Authors: Pfurtscheller Daniel , Schwaberger Bernhard , Höller Nina , Baik-Schneditz Nariae , Schober Lukas , Bruckner Marlies , Schlatzer Christoph , Urlesberger Berndt , Pichler Gerhard 
Published: May 2024

AbstractThe transition from intrauterine to extrauterine life is a critical period for neonates. Assessing the cardiovascular transition during this period immediately after birth is crucial but challenging. The present study compares adjusted estimated cardiac output values calculated by the Liljestrand and Zander formula (COest/adj LaZ) with non-invasively measured cardiac output values (CO-bioimpedance) during immediate transition after birth. We performed a secondary outcome analysis of a prospective observational study in preterm and term neonates. Ten and 15 min after birth, arterial blood pressure and heart rate were assessed, and CO-bioimpedance was measured using electrical bioimpedance method (Aesculon monitor, Osypka, Germany). We calculated COest/adj LaZ and compared it to CO-bioimpedance. Further, we performed a correlation analysis. Thirty-two neonates with a median (IQR) gestational age of 37.0 (32.0–39.4) weeks were included. Mean ± SD CO-bioimpedance was 0.62 ± 0.15 l/min, and COest/adj LaZ was calculated to be 0.64 ± 0.10 l/min, whereby both correlated significantly (p = 0.025, r = 0.359) with each other. Conclusion: The present study demonstrates high comparability of COest/adj LaZ and CO-bioimpedance in neonates during immediate transition after birth, suggesting that cardiac output can be derived in a cost-effective and feasible manner if other methods are not available.

What is Known:• Echocardiography is considered the gold standard for non-invasive CO evaluation, but its feasibility during the immediate transition period is limited.

What is New:• Non-invasive methods such as CO-bioimpedance for cardiac output (CO) measurement and the Liljestrand and Zander (LaZ) formula for estimating CO offer promising alternatives during the immediate transition period.
LAMP2A regulates cisplatin resistance in colorectal cancer through mediating autophagy
Authors: Shi Zhiliang , Yang Shuting , Shen Chenglong , Shao Jiazhe , Zhou Fang , Liu Haichen , Zhou Guoqiang 
Published: May 2024

Abstract
Background
Drug resistance is an important constraint on clinical outcomes in advanced cancers. LAMP2A is a limiting protein in molecular chaperone-mediated autophagy. This study was aimed to explore LAMP2A function in cisplatin (cis-diamminedichloroplatinum, DDP) resistance colorectal cancer (CRC) to seek new ideas for CRC clinical treatment.

Methods
In this study, LAMP2A expression was analyzed by molecular experimental techniques,such as qRT-PCR and western blot. Then, LAMP2A in cells was interfered by cell transfection experiments. Subsequently, the function of LAMP2A on proliferation, migration, invasion, DDP sensitivity, and autophagy of CRC/DDP cells were further investigated by a series of experiments, such as CCK-8, transwell, and western blot.

Results
We revealed that LAMP2A was clearly augmented in DDP-resistant CRC and was related to poor patient prognosis. Functionally, LAMP2A insertion remarkably CRC/DDP proliferation, migration, invasion ability and DDP resistance by strengthen autophagy. In contrast, LAMP2A knockdown limited the proliferation, migration, and invasion while heightened cellular sensitivity to DDP by restraining autophagy in CRC/DDP cells. Furthermore, LAMP2A silencing was able to curb tumor formation and enhance sensitivity to DDP in vivo.

Conclusion
In summary, LAMP2A boosted malignant progression and DDP resistance in CRC/DDP cells through mediating autophagy. Clarifying LAMP2A function in DDP resistance is promising to seek cancer therapies biomarkers targeting LAMP2A activity.
New statistical framework for interlaboratory evaluation of anti-doping testing results by WADA
Authors: Meija Juris , Possolo Antonio , Garrido Bruno Carius , Kisoona Sanjana , Barroso Osquel 
Published: May 2024

AbstractThe World Anti-doping Agency (WADA) International Standard for Laboratories (ISL), developed as part of the World Anti-Doping Program, requires satisfactory laboratory performance in the WADA External Quality Assessment Scheme (EQAS) in order to obtain and maintain WADA accreditation. Under this mandate, WADA regularly distributes urine and blood test samples to anti-doping laboratories to continuously monitor their proficiency. Over the years, WADA has employed classical, generic statistical methods, in accordance to ISO 13528, to evaluate quantitative EQAS results. Here, we set out the rationale for a modern statistical approach that recognizes and addresses the particular features of the measurement results typically obtained in such tests and present an approach involving Bayesian measurement models and statistical data analysis that is tailored specifically to anti-doping testing.
Enhancing statistical chart accessibility for people with low vision: insights from a user test
Authors: Alcaraz-Martínez Rubén , Ribera Mireia , Adeva-Fillol Adrià , Pascual-Almenara Afra 
Published: May 2024

AbstractA remote user test was performed with two versions (one accessible and one non-accessible) of three types of web-based charts (horizontal bar chart, vertical stacked bar chart, and line chart). The objectives of the test were: (a) to validate a set of heuristic indicators for the evaluation of the accessibility of statistical charts presented in a previous work (Fariñas Falcón et al. in Mediocentro Electrónica 21(1):65–68, 2017); (b) to identify new barriers and preferences for users with low vision in the access and use of this content not previously contemplated. 12 users were tested, with a variety of conditions associated with low vision: low visual acuity (6 users), reduced central vision (2 users), reduced peripheral vision (2 users), blurry vision (1 user), sensitivity to light (3 users), Nystagmus (2 users) and color vision deficiency (CVD) (4 users). From a quantitative standpoint, accessible versions of charts were more efficient, effective, and satisfactory. From a qualitative point of view, results verify the relevance of heuristics H2, Legend; H3, Axes; H6, Data source (as data table); H10, Safe colors; H11, Contrast; H12, Legibility; H13, Image quality; H14, Resize; H16, Focus visible; H17, Independent navigation; related to the proposed tasks. As new observations, tooltips were highly valued by all users, but their implementation must be improved to avoid covering up significant parts of the charts when displayed. The data table has also been frequently used by all users, especially in the non-accessible versions, allowing them to carry out tasks more efficiently. The position and size of the legend can be a significant barrier if it is too small or appears in an unusual position. Finally, despite the limitations related to color perception, some users prefer color graphics to black and white, so, to target all profiles, it is necessary to redundantly encode categories with colors and patterns as well.
The hidden truth: unexpected acorn caching sites by Eurasian Jays (Garrulus glandarius L.) re-examined
Authors: Wróbel Aleksandra , Kurek Przemysław , Bobiec Andrzej 
Published: May 2024

AbstractEurasian Jays (Garrulus glandarius) typically store seeds on the ground in shallow caches, promoting tree recruitment. However, speculation exists that Eurasian Jays occasionally store a portion of seeds in microhabitats unsuitable for proper germination. Here, we report that unexpected caching sites in Eurasian Jays can be much more widespread than previously considered and despite their accidental character it seems to be a durable aspect of Eurasian Jay’s hoarding behavior. Out of 259 removed acorns of Pedunculate Oak (Quercus robur), we localized 31 consumed and 222 stored acorns. Six experimental acorns (3% of stored acorns) were found stored by jays in unexpected caching sites: (i) above the ground on individuals of Scots Pine (Pinus sylvestris), (ii) inside the woody stems of Reynoutria sp. individuals, (iii) in a rotten trunk, and (iv) among ruin debris. Our findings suggest the need to revise our understanding of so-called unexpected caching in Eurasian Jays. This highlights a previously overlooked aspect of oak-jay interactions, offering a valuable piece to the puzzle.
Intergenerational Ambivalence, Self-differentiation and Ethnic Identity: A Mixed-methods Study on Family Ethnic Socialization
Authors: Yao Hong , Hou Yajie , Hausmann-Stabile Carolina , Lai Angel Hor Yan 
Published: May 2024

AbstractEthnic identity, profoundly influenced by familial factors, embodies multifaceted layers; yet, the intricate process of family ethnic socialization warrants deeper exploration. This study focuses on exploring the complexities of ethnic identity formation, specifically within the context of Yi adolescents. Employing a mixed-methods approach, it delves into family ethnic socialization dynamics among Yi adolescents. The research engaged 606 surveyed participants and conducted interviews with 188 individuals in focused group settings in Liangshan Yi Autonomous Prefecture, Sichuan Province, China. Quantitative analysis revealed correlations between caregiver-adolescent relationships (CAR) and ethnic identity. Adolescents experiencing ambivalent, positive, or neutral CAR exhibited higher ethnic identity levels than those with negative CAR. Qualitative analysis highlighted two key themes. Firstly, families tended to acculturate love through traditional cultural expectations and socialization, demonstrated through unconscious integration of Yi culture and a focus on individual modernity within family values. Secondly, ethnic identity attainment was observed through self-differentiation, including reflexive awareness of Yi ethnicity, enrichment of Yi identity through peer interactions, and the connection of self-actualization with Yi prosperity. The findings emphasize the need for culturally sensitive support, particularly for social workers, to facilitate reflexive self-differentiation among ethnic minority adolescents during family ethnic socialization.
Sperm epigenetics and sperm RNAs as drivers of male infertility: truth or myth?
Authors: Leggio Loredana , Paternò Greta , Cavallaro Fabrizio , Falcone Marco , Vivarelli Silvia , Manna Claudio , Calogero Aldo E. , Cannarella Rossella , Iraci Nunzio 
Published: May 2024

Abstract
Male infertility represents a complex clinical condition that often challenges the ability of reproductive specialists to find its etiology and then propose an adequate treatment. The unexplained decline in sperm count, as well as the association between male infertility and mortality, morbidity, and cancer, has prompted researchers toward an urgent need to better understand the causes of male infertility. Therefore, molecular biologists are increasingly trying to study whether sperm epigenetic alterations may be involved in male infertility and embryo developmental abnormalities. In this context, research is also trying to uncover the hidden role of sperm RNAs, both coding and non-coding. This narrative review aims to thoroughly and comprehensively present the relationship between sperm epigenetics, sperm RNAs, and human fertility. We first focused on the technological aspects of studying sperm epigenetics and RNAs, relating to the complex role(s) played in sperm maturation, fertilization, and embryo development. Then, we examined the intricate connections between epigenetics and RNAs with fertility measures, namely sperm concentration, embryo growth and development, and live birth rate, in both animal and human studies. A better understanding of the molecular mechanisms involved in sperm epigenetic regulation, as well as the impact of RNA players, will help to tackle infertility.
From Social Stress and Isolation to Autonomic Nervous System Dysregulation in Suicidal Behavior
Authors: Alacreu-Crespo Adrián , Sebti Emma , Moret Rosa María , Courtet Philippe 
Published: May 2024

Abstract
Purpose of Review
In this narrative review we wanted to describe the relationship of autonomic nervous system activity with social environment and suicidal spectrum behaviors.

Recent Findings
Patients with suicidal ideation/suicide attempt have higher sympathetic nervous system (SNS) and lower parasympathetic nervous system (PNS) activity in resting conditions and during acute stress tasks compared with patients without suicidal ideation/suicide attempt. Death by suicide and violent suicide attempt also are related to SNS hyperactivation. Similarly, a SNS/PNS imbalance has been observed in people with childhood trauma, stressful life events or feelings of loneliness and isolation. Social support seems to increase PNS control and resilience.

Summary
Due to the importance of the social context and stressful life events in suicidal behavior, SNS/PNS imbalance could act as a mediator in this relationship and be a source of relevant biomarkers. Childhood trauma and stressful life events may impair the autonomic nervous system response in suicidal patients. Loneliness, isolation and social support may act as moderators in acute stress situations.