bluuebunny/crossref_metadata_2025_split huggingface dataset:
Quality of sleep in escitalopram‐treated female patients with panic disorder
Authors: Todder D. , Baune B. T. 
Published: January 2010

AbstractObjectiveThe purpose of this study was to assess the development of the night‐activity rhythm and quality of sleep during escitalopram treatment of patients suffering from panic disorder.MethodsFifteen women with panic disorder were included and followed‐up over a 5‐week study period during treatment with escitalopram. An age‐matched control group of 15 women were also assessed for 1 week. Motor activity was continuously measured with an electronic wrist device (Actiwatch), sleep was assessed with the Pittsburgh sleep quality index (PSQI) and patients were clinically assessed with the panic and agoraphobic scale (P&A), the global assessment of functioning (GAF) score, the Hamilton depression and anxiety scales (HAM‐D, HAM‐A) and the clinical global impression (CGI) score.ResultsThere was a statistically significant difference on the self‐rated PSQI between the panic disorder patients and the control group. This difference disappeared after 4 weeks of treatment with escitalopram. There was no statistically significant difference of the objective measurements of the Actiwatch between the patients and the control group. In addition, no statistically significant changes were found in the actigraphy measurements at the beginning and the end of the treatment period for patients with panic disorder.ConclusionsPatients with panic disorder rate their sleep worse than healthy controls. Treatment with escitalopram improved the subjective quality of sleep, whereas objective measures remained unchanged during treatment. Copyright © 2010 John Wiley & Sons, Ltd.
Laser‐induced shape transformation and electrophoretic analysis of triangular silver nanoplates
Authors: Kim Jong‐Yeob , Kim Seol Ji , Jang Du‐Jeon 
Published: January 2010

AbstractThe shape transformation of silver triangular nanoplates induced by nanosecond laser pulses has been monitored using agarose gel electrophoresis as well as optical spectroscopy and electron microscopy. Laser irradiation truncates the vertices of the triangular nanoplates, having an average edge size of 110 nm and an average thickness of 14 nm, to form nearly regular‐hexagonal and spherical silver nanoplates gradually. The surface‐enhanced Raman scattering of 4‐nitrobenzenethiol absorbed on silver nanoparticles has been found to decrease enormously with laser irradiation, showing its strong dependence on the shape transformation of nanostructures. Electrophoretic mobility values have been found to decrease substantially with the increase of irradiation time, indicating that the surface charge density of silver nanoplates has been modified largely by laser pulses.
Clinical characteristics of essential voice tremor: A study of 34 cases
Authors: Sulica Lucian , Louis Elan D. 
Published: January 2010

AbstractObjectives/Hypothesis:To describe and characterize essential voice tremor, including signs, symptoms, and severity, and its relation to other manifestations of essential tremor. Description of aspects of treatment is a secondary goal.Study Design:Descriptive clinical cohort study.Methods:Thirty‐four patients with essential voice tremor were identified over 40 months. Historical information regarding duration, family history, ethanol effect, arm tremor, and prior diagnosis was collected and examination was performed. Laryngeal and pharyngeal signs were graded using the Vocal Tremor Scoring System (VTSS); arm tremor was scored using the Washington Heights Inwood Genetic Study of Essential Tremor Rating Scale (WHIGET). Patients rated vocal disability using the Voice Handicap Index (VHI). Information regarding treatment was collected both historically and prospectively.Results:Ninety‐three percent of patients were female. Voice tremor typically began in the seventh decade (62.9 ± 15.0 years), and had been present for a mean of 6.7 ± 13.4 years at the time of presentation. Tremor was present in a first‐degree relative in 13 patients (38.2%); nine (26.5%) reported a beneficial effect of ethanol. Only 11 (32.3%) were aware of an arm tremor. Seven patients (20.6%) had been correctly diagnosed prior to evaluation; 16 (47.1%) were undiagnosed, and 10 (29.4%) had been misdiagnosed as spasmodic dysphonia. Clinical features were scored as follows: VTSS = 7.7 ± 3.3, range 1 to 14; WHIGET = 8.5 ± 7.5, range 0 to 31; VHI = 71 ± 28, range 2 to 115. VTSS did not correlate with WHIGET, but did correlate with VHI. Only 56% of treated patients found botulinum toxin helpful.Conclusions:Essential voice tremor appears to affect more women than men. One third to one half of affected individuals have a family history of tremor. About one half of cases occur with upper extremity tremor no more severe than that seen in similarly aged normal individuals, contrary to what has been thought to date. Essential voice tremor is probably more common than is generally suspected, and many cases appear to be undiagnosed many years after onset or are misdiagnosed, most often as spasmodic dysphonia. The key feature is kinetic laryngeal tremor which usually extends beyond the larynx to involve the phonatory apparatus globally. Botulinum toxin may be helpful, but benefit is typically incomplete and not universal. Prolonged postinjection breathiness is the most common barrier to useful treatment. Laryngoscope, 2010
Complete assignments of 1H and 13C NMR data of three new dihydrophenanthrofurans from Pleione yunnanensis
Authors: Dong Hailing , Wang Chunlan , Li Yan , Guo Shunxing , Yang Junshan 
Published: January 2010

AbstractThree new dihydrophenanthrofurans, pleionesins A–C (1–3), together with two known dihydrophenanthrenes (4–5) were isolated from the tubers of Pleione yunnanensis (Rolfe). The complete 1H and 13C NMR spectra assignments of these compounds were carried out using 1D and 2D NMR experiments (1H, 13C, selective 1D NOE, HSQC and HMBC). Copyright © 2010 John Wiley & Sons, Ltd.
First trimester aneuploidy screening in the presence of a vanishing twin: implications for maternal serum markers
Authors: Spencer K. , Staboulidou I. , Nicolaides K. H. 
Published: January 2010

AbstractObjectiveTo assess the impact of a vanishing twin on the levels of the biochemical markers used in the first trimester aneuploidy screening.MethodsA retrospective analysis of free β‐hCG and PAPP‐A levels in 270 women with a normal singleton fetus with ultrasound evidence of a vanishing twin pregnancy. Marker levels (as MoM) were compared in three groups—76 women with a second empty gestational sac, 194 women with a second gestational sac containing a dead fetus with a measurable crown rump length (CRL), and 1360 matched singleton pregnancies.ResultsIn women with a second empty gestational sac, the median free β‐hCG and PAPP‐A MoMs (0.968 and 1.040, respectively) were not significantly different from the 1.0 MoM in singleton pregnancies. In the group with a vanished twin with a measurable—CRL—there was a significantly increased median PAPP‐A MoM (1.317) but the median free β‐hCG MoM was not changed (1.024). Modelling this bias in PAPP‐A MoM the detection rate for trisomy 21 would fall from 85 to 75%.ConclusionFirst trimester screening in the presence of a vanishing twin may lead to errors in risk estimation. In such circumstances it may be advisable to restrict screening to the use of nuchal translucency (NT) alone. Copyright © 2009 John Wiley & Sons, Ltd.
Adverse drug reactions to antiretroviral therapy (ART): an experience of spontaneous reporting and intensive monitoring from ART centre in India
Authors: Modayil Retty Rajan , Harugeri Anand , Parthasarathi Gurumurthy , Ramesh Madhan , Prasad Rajendra , Naik Vasudeva , Giriyapura Vamadeva 
Published: January 2010

AbstractPurposeTo assess the nature, severity, predictability and preventability of adverse drug reactions (ADRs) and to identify risk factors for antiretroviral ADRs.MethodsEnrolled ambulatory patients were intensively monitored for ADRs. Spontaneously reported ADRs by clinicians were also included. Predictability was assessed based on history of previous exposure to the drug or literature incidence of ADRs. Preventability was assessed using Schumock and Thornton criteria and severity was assessed using modified Hartwig and Siegel scale. Bivariate analysis and subsequently multivariate logistic regression were used to identify the risk factors for ADRs. Data from spontaneous reporting was assessed using Bayesian neural network method for possible ADR signals.ResultsMonitoring by active surveillance indentified 159 (52.82%) ADRs from 400 patients. One hundred and forty‐two (47.17%) reactions were spontaneously reported. Anaemia and vomiting were the most commonly observed ADRs. The ADRs were severe in 10.9% of cases. A total of 88% ADRs were definitely/probably preventable. Use of Zidovudine+Lamivudine with Nevirapine or Efavirenz, CD4 <200 cells/µl, female gender, tuberculosis and illiteracy were observed as risk factors for ADRs by bivariate analysis. Concurrent tuberculosis was the only influential risk factor for development of ADRs identified by multivariate logistic regression.ConclusionPrevalence of ADRs in intensively monitored patients was found to be 39.7%. Tuberculosis in HIV patients is an influential risk factor for occurrence of ADRs. With the increasing access to antiretrovirals in India, ADRs to antiretrovirals require monitoring and reporting. Copyright © 2010 John Wiley & Sons, Ltd.
Identification and analysis of residues contained on β → α loops of the dual‐substrate (βα)8 phosphoribosyl isomerase A specific for its phosphoribosyl anthranilate isomerase activity
Authors: Noda‐García Lianet , Camacho‐Zarco Aldo R. , Verdel‐Aranda Karina , Wright Helena , Soberón Xavier , Fülöp Vilmos , Barona‐Gómez Francisco 
Published: January 2010

AbstractA good model to experimentally explore evolutionary hypothesis related to enzyme function is the ancient‐like dual‐substrate (βα)8 phosphoribosyl isomerase A (PriA), which takes part in both histidine and tryptophan biosynthesis in Streptomyces coelicolor and related organisms. In this study, we determined the Michaelis–Menten enzyme kinetics for both isomerase activities in wild‐type PriA from S. coelicolor and in selected single‐residue monofunctional mutants, identified after Escherichia coli
in vivo complementation experiments. Structural and functional analyses of a hitherto unnoticed residue contained on the functionally important β → α loop 5, namely, Arg139, which was postulated on structural grounds to be important for the dual‐substrate specificity of PriA, is presented for the first time. Indeed, enzyme kinetics analyses done on the mutant variants PriA_Ser81Thr and PriA_Arg139Asn showed that these residues, which are contained on β → α loops and in close proximity to the N‐terminal phosphate‐binding site, are essential solely for the phosphoribosyl anthranilate isomerase activity of PriA. Moreover, analysis of the X‐ray crystallographic structure of PriA_Arg139Asn elucidated at 1.95 Å herein strongly implicates the occurrence of conformational changes in this β → α loop as a major structural feature related to the evolution of the dual‐substrate specificity of PriA. It is suggested that PriA has evolved by tuning a fine energetic balance that allows the sufficient degree of structural flexibility needed for accommodating two topologically dissimilar substrates—within a bifunctional and thus highly constrained active site—without compromising its structural stability.
sRAMP: secure reconfigurable architecture and mobility platform
Authors: Hung Shao‐Hsiu , Yeh Jui‐Hung , Chen Jyh‐Cheng 
Published: January 2010

AbstractMany wireless systems have been proposed and deployed for decades. However, most of them are incompatible. It is expected that various wireless systems will still coexist in the near future. How to integrate them, thus, is an important issue. The integration should be done in both radio access network (RAN) and core network. A mobile user could overcome the incompatibility of different RANs by using multiple radio interfaces or software defined radio (SDR). However, it still requires a common core network to achieve universal roaming. If it is not possible to deploy a common core network, different core networks should be compatible. Unfortunately, standard organizations have been defining their own core networks. The roaming among heterogeneous networks, thus, has become a challenge. Earlier, we have proposedReconfigurable Architecture and Mobility Platform(RAMP) to address this issue. However, RAMP mainly considers mobility management. In this paper, we presentsecureRAMP (sRAMP) which extends RAMP to support reconfigurability in security. This paper presents the design and implementation of sRAMP. To demonstrate the feasibility of sRAMP, a testbed has been constructed. This paper also presents the experimental results conducted by using the testbed. Furthermore, a brief comparison between the proposed sRAMP and other related studies is also presented. Copyright © 2010 John Wiley & Sons, Ltd.
A challenge‐based trust establishment protocol for peer‐to‐peer networks
Authors: Chen Pei‐Te , Laih Chi‐Sung 
Published: January 2010

AbstractEstablishing trust relationships between peers is an essential approach to prevent threats. Most current approaches concentrate on polling algorithms to evaluate peer trustworthiness, but these approaches are either system‐expensive or inefficient. In this paper, we propose a concrete challenge‐based trust protocol for P2P networks. Our protocol uses challenge‐response operations in each trust evaluation phase and validates every contacted peer along with recording their corresponding trust value. The scheme in our protocol utilizes random selection of challenges, and does not reveal additional information, so malicious peers have little opportunity to tamper with the P2P systems. Simulation results show our protocol saves communication cost by around 90%. We suggest a tolerance value of 0.2 which gives a design reference for implementing new P2P trust‐establishing protocols. Copyright © 2010 John Wiley & Sons, Ltd.
X‐ray photoelectron analysis of surface functional groups on diamond‐like carbon films by gas‐phase chemical derivatization method
Authors: Takabayashi Susumu , Okamoto Keishi , Motoyama Hiroaki , Nakatani Tatsuyuki , Sakaue Hiroyuki , Takahagi Takayuki 
Published: January 2010

AbstractOxygen‐related surface functional groups on diamond‐like carbon (DLC) films were derivatized with fluorine‐ and nitrogen‐related groups by the gas‐phase chemical derivatization (GCD) method, and the groups were analyzed quantitatively by X‐ray photoelectron spectroscopy (XPS). It is desirable that a derivatization reaction is unique to the target group; however, it usually causes undesirable side reactions which affect other groups. This diversity of the reactions has complicated the analysis. In this report, we have overcome the problem by applying a mathematical treatment which takes the side reactions into account. This improved analysis shows that it is no longer necessary to have derivatization reactions unique to the target groups. As a result, it is demonstrated that the carbonyl (CO) group is the dominant surface functional group on both the DLC and its wet‐oxidized films, the carboxyl (COOH) group plays a minor role, and the presence of the hydroxyl (OH) group is logically denied. Considering the oxidation steps of these oxygen‐related surface functional groups, it is suggested that the CO group on the DLC films requires the cleavage of the carbon–carbon bond with a relatively high activation energy barrier to change into the COOH group. Copyright © 2010 John Wiley & Sons, Ltd.
A novel method for manufacturing of aluminum foam sandwich panels
Authors: Nabavi A. , Vahdati Khaki J. 
Published: January 2010

AbstractIn this study, a novel method for manufacturing aluminum foam sandwich (AFS) panels via self‐propagating high temperature synthesis (SHS) has been introduced and investigated. In this method, a powder mixture of metallic aluminum and copper oxide was placed in core–sheet interface. Sandwich panel was then heated under static pressure. During heating, SHS reaction (3CuO + 2Al = Al2O3 + 3Cu, ΔH < 0) occurred in the interface. The generated heat from this exothermic reaction caused sheets to join the core by melting the interface and nearby. In order to evaluate the shear strength of the interface, the shear test was applied on manufactured sandwich panels, and its results were compared with those obtained from testing the sandwich panels which were produced by diffusion bonding process. Furthermore, by the aid of energy dispersive spectrometer (EDS) and X‐ray diffraction (XRD) analyses, the formation of copper in the core–sheet interface and its diffusion into the sheets and the core were investigated. In addition, by plotting the hardness values of the panels' sheets across distance, it was found that the generated heat of the exothermic reaction caused a local melting of the panel sheets and the core. These results approved that core to sheet joining in metal foam sandwich panels took place because of the SHS reaction. Significantly, this new method could be applied as a proper and alternative method for production of AFS panels. Copyright © 2010 John Wiley & Sons, Ltd.
Fabrication and characterization of silicon pillars formed by nanosecond pulsed excimer laser in vacuum
Authors: Djemaa A. , Gabouze N. , Yaddadene C. , Belaroussi Y. , Kerdja T. , Kechouane M. , Menari H. , Khereddine A. Y. 
Published: January 2010

AbstractArrays of well defined silicon microcolumns were formed by cumulative nanosecond pulsed excimer laser irradiation of single‐crystal silicon in vacuum. The changes in silicon surface morphology were systematically determined and compared as the number of KrF laser shots was increased from 1 to 15 000 in vacuum. Moreover, as the number of laser shots increases, formation of well defined silicon pillars oriented towards the laser beam has been observed. Finally, the reflectance spectra show a total reflectance of 5%–6% in the wavelength region 375–800 nm and that of 0% at a wavelength of about 870 nm. Copyright © 2010 John Wiley & Sons, Ltd.
[177Lu‐DOTA0‐Tyr3]‐Octreotate Treatment in Patients with Disseminated Gastroenteropancreatic Neuroendocrine Tumors: The Value of Measuring Absorbed Dose to the Kidney
Authors: Swärd Christina , Bernhardt Peter , Ahlman Håkan , Wängberg Bo , Forssell‐Aronsson Eva , Larsson Maria , Svensson Johanna , Rossi‐Norrlund Rauni , Kölby Lars 
Published: January 2010

AbstractBackgroundPeptide receptor radiation therapy (PRRT) using [177Lu‐DOTA0‐Tyr3]‐octreotate is a new, promising option for treatment of disseminated gastroenteropancreatic neuroendocrine tumors (GEPNETs).MethodsDuring 2006‐2008, 26 patients with disseminated GEPNETs were treated with 177Lu‐octreotate. Radiologic response (RECIST), biochemical response [plasma chromogranin‐A (P‐CgA)], hematologic toxicity [Common Toxicity Criteria (CTC)], absorbed dose to the kidneys (conjugate view method), and glomerular filtration rate (GFR) were analyzed.Results177Lu‐octreotate (8 GBq) was given one to five times (median = 3) with a 6‐week interval between each. Sixteen of the 26 patients were evaluated radiologically; 6 (38%) had partial response (PR), 8 (50%) had stable disease (SD), and 2 (13%) had progressive disease (PD). Seventeen of the 26 patients were evaluated biochemically; 6 (35%) showed a ≥30% decrease, 8 (47%) showed a ≥20% increase, and 3 (18%) showed neither a ≥30% decrease nor a ≥20% increase. The mean absorbed dose to the kidneys was 24 Gy. With a dose limit of 27 Gy to the kidneys, 10 patients did not receive the planned four treatments, while four patients had the potential to receive additional treatment. A significant reduction (p = 0.0013) of GFR was observed at follow‐up. Three patients experienced CTC grade 3 hematologic toxicity.ConclusionsBy using the absorbed dose to the kidneys as a limiting factor, treatment with 177Lu‐octreotate can be individualized, e.g., overtreatment can be avoided and patients with the potential to receive additional treatment can be identified. Further studies are needed to define tolerance doses to the kidneys so that treatment can be optimized.
Neighborhoods as a Developmental Context: A Multilevel Analysis of Neighborhood Effects on Head Start Families and Children
Authors: Vaden-Kiernan Michael , D'Elio Mary Ann , O'Brien Robert W. , Tarullo Louisa Banks , Zill Nicholas , Hubbell-McKey Ruth 
Published: January 2010

AbstractNeighborhoods have been recognized in theory and research as an important context for child development. This study used data from the Head Start Family and Child Experiences Survey (FACES) and Census 2000 to assess the underlying factor structure and impact of neighborhood factors on child cognitive and behavioral outcomes, including the critical family and social factors that may mediate and/or moderate these relationships. Factor analyses found five factors described Head Start neighborhoods. After controlling for family and child factors, multilevel analyses found significant direct effects of neighborhood factors on Head Start children's cognitive and behavioral outcomes. There were no mediation effects found for family or social variables between neighborhood factors and child outcomes. A large number of moderation effects were found although there was not a clear pattern to the results. Future research, policy, and practice implications are discussed.
Clinical and biochemical monitoring of patients with fatty acid oxidation disorders
Authors: Lund Allan Meldgaard , Skovby Flemming , Vestergaard Helle , Christensen Mette , Christensen Ernst 
Published: January 2010

AbstractEvidence‐based guidelines for monitoring patients with disorders in fatty acid oxidation (FAO) are lacking, and most protocols are based on expert statements. Here, we describe our protocol for Danish patients. Clinical monitoring is the most important measure and has the main aims of checking growth, development and diet and of bringing families to the clinic regularly to remind them of their child's risk and review how they cope and adjust, e.g. to an acute intercurrent illness. Most of these measures are simple and can be carried out during a routine out‐patient visit; we seldom do more complicated assessments by a neuropsychologist, speech therapist, or physical and occupational therapists. Paraclinical measurements are not used for short‐chain and medium‐chain disorders; electrocardiography (including 24 h monitoring) and echocardiography are done for most patients with long‐chain and carnitine transporter deficiencies. Eye examination is done in all, and liver ultrasonography in some patients with long‐chain 3‐hydroxyacyl‐coenzyme A dehydrogenase/tri‐functional protein (LCHAD/TFP) deficiencies. Biochemical follow‐up includes determination of free carnitine and acylcarnitines. Free carnitine is measured to monitor carnitine supplementation in patients with multiple acyl‐coenzyme A dehydrogenase deficiency (MADD) and carnitine transporter deficiency (CTD) and to follow metabolic control and disclose deficiency states in other FAO disorders. We are evaluating long‐chain acylcarnitines in patients with long‐chain disorders; so far there does not seem to be any clear‐cut benefit in following these levels. An erythrocyte fatty acid profile is done in patients with long‐chain disorders to test for essential fatty acid and docosahexanoic acid (DHA) deficiencies. The measurement of creatine kinase is helpful in long‐chain disorders. Ongoing follow‐up and education of the patient is important throughout life to prevent disease morbidity or death from metabolic crises.