bluuebunny/crossref_metadata_2025_split huggingface dataset:
P03-192 - Is Affective Temperament Related To Perception Of Stigma In Epilepsy?
Authors: Yazici A.B. , Yazici E. , Aydın N. , Orhan A. , Kırpınar I. 
Published: June 2010

ObjectiveAffective Temperaments (AT) in epilepsy is waiting for a clear understanding as antecedents of mood disorders. Recent studies suggest that perception of stigma (PS) correlates with high anxiety and depression scores in epilepsy patients.In this study we investigated if there is association between AT, PS and depression in epilepsy.MethodsConsequent 71 outpatients (40 women 31 men) with epilepsy were included in the study and examined using the Temperament Evaluation of Memphis, Pisa, Paris and San Diego-Autoquestionnaire version (TEMPS-A), Epilepsy Stigma Scale, SCID-I for DSM IV for the diagnosis of depression.ResultsDepressive temperament (DT) scores were positively correlated with PS scores (r:0,247, p< 0.05) in whole group. PS scores were significantly higher in epileptics with MDD group (n:14) than epileptics without MDD(n:57) (t -3.052, p< 0.05). than the patients were divided into groups as patients with DT (n:10), patients with MDD (n: 9) and patients with MDD and DT (n: 5). In One Way ANOVA analysis there was difference between groups. By Tukey HSD the Perception of Stigma was not different between DT and MDD grup but DT+MDD group was significantly higher than DT group.ConclusionRecent studies suggest that a crucial part of inherited factors of depression is mediated by ATs and in some studies DT is founded to be related with recurrent depressive disorder. This study suggest that there may be an association between PS, DT and MDD alone but coexistence of MDD and DT is a higher risk for higher levels of stigma perception.
P03-193 - Sociodemographical And Clinical Characteristics As Determinant Factors In The Derivation To Long Stay Units
Authors: Zallo E. , Uriarte J.J. , Ballesteros J. , Zumárraga M. 
Published: June 2010

ObjectivesIt is widely developed the idea of communitary attention of serious mental disorders, instead of being recluded in long stay hospitals. But tomake this project real it is needed a complex sociosanitay support: psychosocial rehabilitation units, protected dwellings…and nowadays some people are still discharged to long term hospitals.The objective of this work is to demonstrate that clinical characteristics are not determinant and that the main reason that supports the decision is the insufficent social resources spread.Methods279 inpatients that entered a Psychosocial rehabilitation unit from January 2005 to April 2009 are selected. There are two comparison groups depending on the derivation to long term units. There are compared different variables taking the HoNOS scale as measurement tool. Ths stathistical comparison test used is the Fisher exact test.HoNOs scale items:
1Disruptive behaviour2Non-accidental self-injury3Alcohol/drug taking4Cognition5Physical illness6Hallucinations/delusions7Depressed mood8Other mental problems9Relationship10Daily activity11Living conditions12Activities/occupationResultsThere is not statistical significance when clinical items of the HoNOS scale (item 1 to 8) are compared, instead of item 5 (p=0,001). There appears significance when comparing social items and specially item 9 (p=0,031),11 (p=0,002) and 12 (0,026).ConclusionsNowadays there is no difference in the clinical profile of inpatients when derivation. The fact of not having adequate living conditions is determinant in the decision of derivation, showing that socio sanitary resources are insufficient for an optimal communitary system.
P03-196 - Prevalence Of Substance Use And Depression Among The University Students In Iran
Authors: Roshandel A. , Safavi Mahboobeh , Rafienejad-Zahra Kheiri Aliazam , Mohamadi ali 
Published: June 2010

Objectivesnowadays drug abuse and addiction is one of the most important health,social and political problems in the world. substance use among university students is a mental health concern. people with depression have high rates of comorbidity with other mental disorders and substance use disorders. the purpose of this study was to determine the prevalence of depression, substance use and the relationship between depression and substance use among student of guilan university of medical sciences(GUMS).Methodsthis was a cross-sectional study carried out on a representative sample of 254 students(n=167girls;n=87boys) of GUMS. The samples were selected randomly by stratified sampling. data was collected using a confidential multiple choice questionnaire detecting the frequency of various substance use. the beck depression inventory(BDI)were used to determine depressive symptoms. Data were analyzed by chi-square and exact fisher test using SPSS ver 16software.Resultsresults showed that the prevalence rate of each substance in use was: Opium (1.2%), Morphine (0.4%), cannabis (1.2%), Cocaine (0.4%), codeine (7.5%), Ritalin (2%), tramadol (4.7%) cristal (0.4%), Amphetamines (0.8%),cigarette (8.3%), alcohol(7.1%). according to BDI,(29.9%)of students had depression.there were significant differences between the prevalence of substance use with gender(p=0/0001),parent marital status(p=0/01)and depression(p=0/01).ConclusionThis study demonstrated that the substance use among students is considerably high and specific interventions seem to be necessary in preventing or reducing the rate of substance use in students. Reading the result of this study,it is suggested that parents and universities authorities have a better over solving students emotional and social problems.
P03-201 - Quetiapine In Alcohol Relapse Prevention - A Case Series
Authors: Croissant B. , Diehl A. , Hermann D. , Mann K. 
Published: June 2010

ObjectivesResearch has shown that Quetiapine reduce the craving and consumption for stimulants and alcohol. Due to Quetiapine's particulars and the promising receptor profile concerning addiction medicine, we set out to examine the tolerability and efficacy concerning relapse prevention of withdrawn alcoholics suffering from additional symptoms.MethodsOur case observations attempted to evaluate nine alcoholics after withdrawal suffering from persisting craving, sleep disorder, excitement, depressive symptoms or anxiety symptoms. The patients were treated with quetiapine as relapse prevention and we followed them up in our outpatient clinic.ResultsEight out of nine patients were abstinent under quetiapine over a period of 2 to 7 months. One of these patients relapsed after he stopped taking the preparation at his own initiative after 10 weeks. The ninths patient stopped taking the preparation immediately because of swollen nasal mucosae. All target symptoms disappeared in the patients after an average of [mean ± SD] 24.5 ± 18.1 days. The overall tolerability was considered to be very good, however initial sleepiness appeared in four patients.ConclusionPatients reported to be very satisfied with the medication. Reports about clearly reduced craving seem particularly worthy of attention. Although uncontrolled case observations can only be interpreted with caution quetiapine seems to deserve further investigation. A double-blind placebo-controlled study is in preparation to confirm these preliminary findings. Quetiapine may hold the potential for preventing alcohol relapse in alcoholics suffering from additional above mentioned symptoms, or as an alternative in alcoholics who do neither tolerate acamprosate nor naltrexone.
P03-203 - Specifics Of Addiction In Women - Heredity And Interpersonal Relations
Authors: Raketic D. 
Published: June 2010

The purpose of this paper is to point out to the significance of heredity and emotional bonding in genesis and development of addiction in women.MethodSample of alcohol and opiate female addicts (30 patients in each group) plus control group (30 women) with no psychiatric diagnosis were questioned with the Semi-structured interview Addiction Severity Index - ASI (T.McLellan, J.Cacciola 1982).ResultsThere is a statistically significant difference among the groups compared for hereditary factors in addiction. In the group of opiate female addicts, a positive hereditary factor is present in 62.5%, in alcohol female addicts - in 50.0%, and in the control group - in 13.3%.Alcohol addicted subjects do not differ significantly from opiate addicted subjects in terms of living with someone who has a drinking problem. However there is a statistically significant difference between opiate addicted subjects who live with someone with a drug problem (62.5%) and alcohol addicted subjects (13.3%).ConclusionHeredity is an important risk factor in addiction. A problem with chemical addiction in families of addicts, as a rule, presents as a multi-generational problem. Opiate addiction, in particular, starts and is maintained in a relationship with either a close family member or a partner.
P03-204 - A Cross-Sectional Pilot Study Of Benzodiazepines Use Among Medical Students In Serbia
Authors: Divac N. , Todorovic Z. , Nesic Z. , Prostran M. 
Published: June 2010

High prevalence of benzodiazepine use among citizens of Serbia has been described previously. The fourth year medical students are supposed to have sufficient knowledge on benzodiazepines, but it is also clear that medical students are not immune to substance use and abuse.This study was conducted to assess the perceptions of a Serbian medical students (fourth year), regarding benzodiazepines utilization.The study was conducted as cross-sectional, using structured questionnaire with 4 multiple-choice questions. The participation was voluntary and anonymous, 112 students participated and the response rate was 87%.Results showed that slightly above half of the students (n=64; 57.1%) classified benzodiazepines correctly as anxiolytics/hypnotics (sedatives), while the others (n=48; 42.9%) non-specifically classified benzodiazepines as drugs acting on central nervous system. The majority of students stated that they never use benzodiazepines (n=72; 64.3%). Among benzodiazepines users (n=40; 35.7%), 100% were occasional users (less than once a week). The main reason for benzodiazepines use was insomnia (n=16; 40.0%), anxiety (n=12; 30.0%) and other reasons, such as tremor, muscle spasms etc. (n=12; 30.0%). The majority of benzodiazepines users (n=28; 70.0%) stated that benzodiazepines did not impair their concentration and studying, while the rest (n=12; 30.0%) noticed mild impairment.Serbian fourth year medical students showed mildly disappointing knowledge on benzodiazepines regarding the classification. However, low rate of benzodiazepines use among students and the lack of recreational use indicate awareness of the risk of drugs misuse in this population.
P03-208 - Correlates And Prevalence Of Substance Use Among Primary Care Patient In Ikorodu, Nigeria
Authors: Erinfolami A. , Olagunju A. , Oguntuase A. , Akinbode A. 
Published: June 2010

Quality of life and sociodemographic factors of patients with unexplained symptom in general practice.ObjectivesWe aimed to evaluate the correlates and prevalence of psychoactive substance use in primary care patients in Ikorodu, Lagos Nigeria.MethodSix Primary Health Care clinics were randomly selected of the public health clinic in Ikorodu area of Lagos. A total of 1,550 were screened with World Health Organization Alcohol, Smoking and substance involvement screening test (ASSIST) between June 2007, and May 2008.ResultsHazardous use of tobacco was most prevalent (30%) especially among 18 - 25 age group, follow by Alcohol and then cannabis. Hazardous use of alcohol was associated with male gender, younger age group and lack of employment. For all substances, we recorded lowest rate for women.ConclusionPsychoactive substance use are common among primary care patients, effective methods of early identification and form of anti drug use education are needed. Younger age groups, especially men are to receive more attention.
P03-210 - Life Quality Of Male Alcohol Dependents At 12 Months Follow-Up
Authors: Evren C. , Durkaya M. , Cetin R. , Dalbudak E. 
Published: June 2010

AimsAim of this study was to investigate the changes in life quality during 12 months follow-up among alcohol dependent inpatients.MethodsParticipants were 102 consecutively admitted male alcohol dependents, whom were available for second evaluation at 12 months follow-up. Patients were investigated with the Medical Outcomes Study Short Form 36-item health survey (SF-36) at the end of inpatient treatment program and 12 months later in follow-up.ResultsAmong alcohol dependent inpatients 61.8% were considered to be relapsed. Sociodemographic variables did not differ between relapsed and non-relapsed groups. Mean scores of physical and mental component summaries did not differ between groups at baseline evaluation, whereas they were lower in relapsed group at 12 months follow-up. In non-relapsed group mean scores of all the life quality subscales and physical and mental component summaries improved at 12 months follow-up, whereas in relapsed group mean scores of life quality did not differ significantly.ConclusionAmong alcohol dependent men life quality improves after 12 months of abstinence following inpatient treatment. Thus after measuring the impairments in life quality, if the findings are communicated to patients, this may enhance their motivation to stay sober after inpatient treatment programs.
P03-212 - Messing With Pleasure: A Smoking Cessation Program In A Psychiatric Hospital
Authors: Ganhao I. , Trigo M. , Paixão A. , Pedro P. , Gonçalves E. 
Published: June 2010

IntroductionMost pleasures have been condemned at some time and many laws have attempted to prohibit supposedly harmful behavior. Evolution has not collaborated perhaps because addictive behaviors, associated with reward and pleasure circuits/centers in the brain, are important for survival.Withdrawal symptoms are treatable with nicotine replacement therapy. Pleasure, is a harder problem to tackle and is associated with rituals, the senses and affect regulation and may be a major culprit in relapse.Dopamine dysregulation may favor addiction and addiction may lead to dopamine dysregulation. Many psychiatric patients may have dopaminergic dysregulation and altered pleasure circuit function and are more prone to addiction, especially to nicotine, and probably harder to help.Objectives/aimsA reflection on desire and pleasure in smokers in general and psychiatric patients and on possible strategies to overcome these difficulties.Methods1)A review of philosophical, sociopolitical, biological and neuropsychiatric views of pleasure2)Rating of smoking as a pleasure on a visual analog scale on first assessment of a smoking cessation program in a psychiatric hospital3)Reflections on difficulties encountered in a smoking cessation program and possible strategies to overcome theseResults and conclusionsTreating addictions poses tremendous challenges since the very mechanisms nature disposed for survival, are those gone awry. Pleasure is identified as a major driving force behind addiction in tobaco smoking therefore should be specifically addressed in smoking cessation programs. Psychiatric patients who smoke tobaco are an especially difficult patient population and one of the contributing factors may be dopamine dysregulation/pleasure dysregulation.
P03-214 - Emotional Intelligence And Its Relation To Human Abnormal Behaviour: Comparison Between Addicted And Nonaddicted People
Authors: Homayouni A. , Bani Hashemi S.A. , Golzadeh E. 
Published: June 2010

ObjectivesEmotional intelligence (E / I) consists of appraisal of emotion in the self and others, regulation of emotion in the self and others and utilization of emotion in solving problems. Subsumed under these branches are functions such as verbal and non verbal appraisal and expression of emotion and using emotions to motivate as part of the utilisation of emotions. (Salovey & Mayer's, 1990). Emotional intelligence components are important in psychological functions such as problem-solving, happiness, stress-tolerance, self-actualization and interpersonal relationship. So the research aimed to investigate role of Emotional intelligence in tendency to addiction.MethodIn sampling process a total of 73 addicted people and 73 non-addicted people were randomly selected. All participants were requested to complete Schutte's Self- Report E / I Test (SSREIT) (33 item). The test measures ability of E / I in three fields: Appraisal of emotion, regulation of emotion and utilization of emotion. In order to analyzing the data independent T test was used to compare means of two groups.ResultsFindings indicated significant differences between two groups in components of emotional intelligent. Nonaddicted people had more scores in appraisal of emotion, utilization of emotion and general score of emotional intelligence. But there was no significant difference in regulation of emotion in two groups.ConclusionConsidering the results, it is recommended to apply the plans for enhancing emotional intelligent components in order to increasing abilities and competencies in confronting with crisis and bad events and reducing risk of abnormal behaviors, specially addiction.
P03-216 - Clinical And Social Functioning, Quality Of Life, Maladjustment Of Hiv-Positive Injection-Drug Consumers
Authors: Dakukina T. , Stan’ko E. , Ihumnau S. 
Published: June 2010

ObjectivesThe epidemiology of HIV in Belarus, main trends in addiction treatment, attitude to rehabilitation of addicts with HIV are presented.ResultsThe questions of social maladjustment of such patients are revealed as well as organization of medical and social rehabilitation and self-maladoption. The correlation between the amount and characteristics of rehabilitating services and the grade of maladjustment is stressed. The analysis of social functioning as well as quality of life of patients with dual pathology ((HIV and addiction) is presented.ConclusionsThe background for different approach towards research of HIV-positive and HIV-negative IV drug consumers is presented.
P03-219 - New Agents For The Benzodiazepine Withdrawal Syndrome
Authors: Marin M. , Riaza M.D. , Quintana A. , Lopez J. , Sánchez L. , Codesal R.A. , Rubio G. 
Published: June 2010

ObjectivesBenzodiazepines are widely used drugs. However, their chronic use has revealed that they can lead to dependence. The objective of this study is to review the different pharmacological strategies used in the management of benzodiazepine dependence and new trends in pharmacological interventions.MethodWe searched in MEDLINE and in the Cochrane Database System Review, selecting studies from 1980 until the present, in which a pharmacological intervention was made for benzodiazepine detoxification in mono-dependence cases.ResultsThere is a consensus about gradual rather than abrupt tapering benzodiazepines in benzodiazepine discontinuation. Other extended traditional strategy has been switching from short half-life to long half-life benzodiazepines before gradual taper. A great variety of agents have been used as adjuvant medication in Benzodiazepine Withdrawal Syndrome (BWS) with varying degrees of success. In the last years research has focus in the use of anticonvulsant drugs. Both carbamzepine and valproate, have demonstrated to be beneficial in benzodiazepine discontinuation. Also, preliminary data suggest that new anticonvulsant agents (gabapentin, pregabalin, oxcarbazepine and topiramate) could be helpful.DiscussionAlthough multiple drugs have been investigated for pharmacological management of BWS, only few have demonstrated significant efficacy. Anticonvulsant drugs are one of them. Both, carbamazepine and valproate, have shown benefits in reducing withdrawal severity. The available data currently support the use of new anticonvulsant (gabapentin, pregabalin, oxacarbazepine and topiramate), in the treatment of different drug-dependences such as alcohol, cocaine and opiate dependence. Moreover, there is a growing trend in the literature toward the use of these agents in benzodiazepine mono-dependence.
P03-236 - New Putative Therapeutic Efficiency Of Methadone In Schizophrenic Patients With Drug-Dependence Sdr
Authors: Mititelu A. 
Published: June 2010

The drug dependence especially opioid dependence, represents at moment a very challenging therapeutic domain, even that huge steps-methadone, buprenorphine, naltrexone-had been discovered.The fact that almost 50% of all drug-induced psychosis results during the progess of disease to various forms of schizophrenia is as well an undeniable truth.The main aim of this retrospective study is to raise the question, upon a possible therapeutic effect of methadone in the clinical evolution of patients diagnosed according with DSMIV with clinical forms of Schizophrenia Sdr which are presenting as well a drug dependence sdr.The study had been realised on patients which were held in various prison establishments. the number of the patients was 24 with age between 24-35 years old, with longstanding history of heroin of heroin abuse(IV user) for tlast 10 years, cocaine/crack user-10 years,10 years of cannabis user.All patients were presenting at the start of the stydy positive symptoms(delusion with presecutory themes; auditive and viusal hallucinations; evident thought disorders) and negative symptoms (apathy, anhedonia, social isolation, even at the point of autistic withdrawal). All of them were under specific treatment with second generation of antipsychotics-e.g. Olanzapine, Risperidone, Aripiprazole.The length of time for the study was of 9 months. During this interval, after they had re start the methadone programme with corect adjusted doses depending on the severity of their drug dependence, it had been seen a massive reduction of negative symptoms but also a semnificative decrease of their positive symptoms-especially hallucinations.The main explanation for this unexpected therapeutic effect is represented by the mechanisms which oipiod substitutes-methadone, esp-exerts upon the dopaminergic pathways (involved in the genesis of schizophrenic pathology).
P03-256 - Psychiatric Comorbidities And Therapeutic Management In Opiate-Dependent Patients Undergoing A Replacement Therapy Program In Spain: The Proteus Study
Authors: Roncero C. , Box B. , Fuste G. , Barral C. , Llaudó J. , Eiroa F. , López C. , Casas M. 
Published: June 2010

IntroductionAccording to 2008 data, there are 80.000 patients undergoing replacement opiate programs (RMP) in Spain. However, the clinical therapeutic management and the psychiatric and medical comorbidities have not been well described.ObjectivesTo describe the current therapeutic management and psychiatric comorbilities of opiate-dependent patients undergoing a RMP in Spain.MethodsWe carried out an observational, cross-sectional, multicenter study from September 2008 to February 2009. Patients > 18 years, with written informed consent, with a opiate-dependence according to DSM-IV-TR criteria and currently scheduled in a RMP in Spain were included.Results624 patients (38.89±7.95 y.o.,84% men) were included in the study from 74 centers.Psychiatric comorbidities were clinically detected in 68% of all valuable patients, most frequently anxiety (53%), mood (48%) and sleep disorders (41%). Patients receiving buprenorphine-naloxone suffered less sleep disorders (19% vs. 43%; p=0.0327) The proportion of patients with at least one psychiatric comorbidity was directly related to methadone dose (p=0.0066).The most frequent replacement therapy was methadone (94%), usually in ≤ 40 mg/day (38%) and 40-80 mg/day doses (40%); mean follow up period being 45.88±51.86 months. Significant differences were found between methadone doses and retention. Patients with HIV and HCV infection received higher doses of methadone (HIV+ patients (p=0.0024) and HCV+/ HIV+ patients (p=0.0250) due to ARV treatment; and showed less PMM retention.ConclusionPatients present high rates of dual diagnosis, and infectious and non-infectious comorbidities, expecting higher doses of methadone than found (54.04±47.26 mg/day) in the study to assure a proper retention in the maintenance programs.