bluuebunny/crossref_metadata_2025_split huggingface dataset:
Negative Regulation of MAVS-Mediated Innate Immune Response by PSMA7
Authors: Jia Yongxia , Song Ting , Wei Congwen , Ni Caifei , Zheng Zirui , Xu Quanbin , Ma Hongfang , Li Li , Zhang Yanhong , He Xiang , Xu Yang , Shi Wei , Zhong Hui 
Published: September 2009

Abstract
Innate immunity to viruses involves receptors such as Retinoic Acid Induced Gene-1 (RIG-I), which senses viral RNA and triggers a signaling pathway involving the outer mitochondrial membrane protein mitochondrial antiviral signaling (MAVS). Recent work has identified that NLRX1, a member of another class of innate immune receptors, sequesters MAVS away from RIG-I and thereby prevents mitochondrial antiviral immunity. In this study, we demonstrate that the proteasome PSMA7 (α4) subunit associates with MAVS in vivo and in vitro. Expression of PSMA7 results in a potent inhibition of RIG-1 and MAVS-mediated IFN-β promoter activity; conversely, depletion of PSMA7 with small interference RNA enhances virus-induced type I IFN production, with consequent reduction of virus replication. Furthermore, a striking reduction in the abundance of endogenous MAVS with overexpressed PSMA7 was found and virus infection leads to transient increase in the endogenous PSMA7 protein level. Cumulatively, these results suggest that PSMA7 is a negative regulator of the MAVS-mediated innate immunity that probably serves to attenuate the establishment of an antiviral state during viral infection, highlighting the biological significance of PSMA7-MAVS association as an important cellular regulatory control.
Innate Immunity against Bacterial Infection following Hyperoxia Exposure Is Impaired in NRF2-Deficient Mice
Authors: Reddy Narsa M. , Suryanarayana Vegiraju , Kalvakolanu Dhananjaya V. , Yamamoto Masayuki , Kensler Thomas W. , Hassoun Paul M. , Kleeberger Steven R. , Reddy Sekhar P. 
Published: September 2009

Abstract
Oxygen supplementation is used as therapy to support critically ill patients with severe respiratory impairment. Although hyperoxia has been shown to enhance the lung susceptibility to subsequent bacterial infection, the mechanisms underlying enhanced susceptibility remain enigmatic. We have reported that disruption of NF-E2-related factor 2 (Nrf2), a master transcription regulator of various stress response pathways, enhances susceptibility to hyperoxia-induced acute lung injury in mice, and have also demonstrated an association between a polymorphism in the NRF2 promoter and increased susceptibility to acute lung injury. In this study, we show that Nrf2-deficient (Nrf2−/−) but not wild-type (Nrf2+/+) mice exposed to sublethal hyperoxia succumbed to death during recovery after Pseudomonas aeruginosa infection. Nrf2-deficiency caused persistent bacterial pulmonary burden and enhanced levels of inflammatory cell infiltration as well as edema. Alveolar macrophages isolated from Nrf2−/− mice exposed to hyperoxia displayed persistent oxidative stress and inflammatory cytokine expression concomitant with diminished levels of antioxidant enzymes, such as Gclc, required for glutathione biosynthesis. In vitro exposure of Nrf2−/− macrophages to hyperoxia strongly diminished their antibacterial activity and enhanced inflammatory cytokine expression compared with Nrf2+/+ cells. However, glutathione supplementation during hyperoxic insult restored the ability of Nrf2−/− cells to mount antibacterial response and suppressed cytokine expression. Thus, loss of Nrf2 impairs lung innate immunity and promotes susceptibility to bacterial infection after hyperoxia exposure, ultimately leading to death of the host.
CXCR3 Directs Antigen-Specific Effector CD4+ T Cell Migration to the Lung During Parainfluenza Virus Infection
Authors: Kohlmeier Jacob E. , Cookenham Tres , Miller Shannon C. , Roberts Alan D. , Christensen Jan P. , Thomsen Allan R. , Woodland David L. 
Published: September 2009

Abstract
Effector T cells are a crucial component of the adaptive immune response to respiratory virus infections. Although it was previously reported that the chemokine receptors CCR5 and CXCR3 affect trafficking of respiratory virus-specific CD8+ T cells, it is unclear whether these receptors govern effector CD4+ T cell migration to the lungs. To assess the role of CCR5 and CXCR3 in vivo, we directly compared the migration of Ag-specific wild-type and chemokine receptor-deficient effector T cells in mixed bone marrow chimeric mice during a parainfluenza virus infection. CXCR3-deficient effector CD4+ T cells were 5- to 10-fold less efficient at migrating to the lung compared with wild-type cells, whereas CCR5-deficient effector T cells were not impaired in their migration to the lung. In contrast to its role in trafficking, CXCR3 had no impact on effector CD4+ T cell proliferation, phenotype, or function in any of the tissues examined. These findings demonstrate that CXCR3 controls virus-specific effector CD4+ T cell migration in vivo, and suggest that blocking CXCR3-mediated recruitment may limit T cell-induced immunopathology during respiratory virus infections.
Wireless Sensor Network Platforms
Authors: Bischoff Reinhard , Meyer Jonas , Feltrin Glauco 
Published: September 2009

AbstractA wireless sensor network is a network made up of many tiny intercommunicating computers equipped with one or several sensors. Each tiny computer represents a node of the network. The nodes are self‐contained units typically consisting of a power supply with limited capacity, a radio transceiver, a microcontroller, and one or more sensors. This article gives an introduction to wireless sensor networks for structural health monitoring, shows the general architecture of sensor nodes, and overviews current hardware and software platforms. Furthermore, it shows the characteristics and limits of such monitoring systems and gives advice to choose a suitable platform to an application. Because nodes are powered by an autonomous source, energy‐related aspects, energy storage, and scavenging are presented as well.
Alkaline hydrolysis of cinnamaldehyde to benzaldehyde in the presence of β‐cyclodextrin
Authors: Chen Hongyan , Ji Hongbing 
Published: September 2009

AbstractA facile, novel, and cost‐effective alkaline hydrolysis process of cinnamaldehyde to benzaldehyde under rather mild conditions has been investigated systematically in the presence of β‐cyclodextrin (β‐CD), with water as the only solvent. β‐CD could form inclusion complex with cinnamaldehyde in water, with molar ratio of 1:1, so as to promote the reaction selectivity. The complex has been investigated experimentally and with computational methods. 1H‐NMR, ROESY, UV–Vis, and FTIR have been utilized to analyze the inclusion complex. It shows that the equilibrium constant for inclusion (Ka) is 363 M−1, and the standard Gibbs function for the reaction, ΔγG (298 K), is −14.6 kJ mol−1. In addition, the structures of the proposed inclusion compounds were optimized with hybrid ONIOM theory. Benzaldehyde could be obtained at an yield of 42% under optimum conditions [50°C, 18 h, 2% NaOH (w/v), cinnamaldehyde:β‐CD (molar ratio) = 1:1]. To explain the experimental data, NMR, FTIR, and elemental analysis results were used to determine the main reaction by‐product 1‐naphthalenemethanol. A feasible reaction mechanism including the retro‐Aldol condensation of cinnamaldehyde and the Aldol condensation of acetaldehyde and cinnamaldehyde in basic aqueous β‐CD solution has been proposed. The calculated activation energy for the reaction was 45.27 kJ mol−1 by initial concentrations method. © 2009 American Institute of Chemical Engineers AIChE J, 2010
Placental insulin‐like growth factor II (IGF‐II) and its relation to litter size in the common marmoset monkey (Callithrix jacchus)
Authors: Rutherford Julienne N. , Eklund Amy , Tardif Suzette 
Published: September 2009

AbstractThe primate placenta produces a wide variety of hormones throughout gestation that regulate placental function and fetal growth. One such hormone is insulin‐like growth factor‐II (IGF‐II), a peptide implicated in cell division, differentiation, and amino acid transport. IGF‐II concentrations were measured in 23 common marmoset (Callithrix jacchus) term placentas from twin and triplet litters in order to determine whether previously described differences in fetoplacental phenotype such as placental and litter mass and placental surface area were related to differences in endocrine function. IGF‐II was extracted from frozen tissue samples and measured using an enzyme‐linked immunosorbent assay kit designed for human tissue, which was validated for marmoset placenta. IGF‐II concentrations were not related to placental or litter mass, and twin and triplet placentas did not differ in total concentration. However, per individual fetus, triplets were associated with a significant 42% reduction in IGF‐II concentration (P=0.03), and IGF‐II concentration per gram of fetal mass was a third lower in triplet litters. The triplet placenta exhibits a global expansion of the surface area which was contrasted by a per unit area reduction in IGF‐II concentration (r=−0.75, P=0.01), a pattern that explains why twin and triplet placentas overall did not differ in concentration. Per fetus, triplet pregnancies are associated with relatively less maternal mass, placental mass and microscopic surface area suggesting that the intrauterine growth of triplets is supported by systems that increase the efficiency of nutrient transfer. The finding that individual triplet fetuses are also associated with significantly lower IGF‐II concentrations is consistent with the view that the marmoset fetoplacental unit exhibits a flexible pattern of placental allocation and metabolism. Plasticity in placental endocrine and metabolic function is likely to play an important role in the ability of the fetus to sense and accommodate the intrauterine environment and, by extension, the external ecology. Am. J. Primatol. 71:969–975, 2009. © 2009 Wiley‐Liss, Inc.
Robust H∞ control for uncertain discrete‐time systems with probabilistic state delays
Authors: Tian Engang , Yue Dong , Wang Zidong 
Published: September 2009

AbstractIn this paper, we propose a novel design problem of robust H∞ control for discrete‐time systems with probabilistic time delay, where both the variation range of the delay and the probability distribution of the delay taking values in an interval are available. Based on the information on the probability distribution of the delay taking values in an interval, a new modeling method is put forward, with which the probabilistic effects of the delay are reflected into a parameter matrix of certain transformed system. Based on such a new model, criteria for the H∞ control design are derived by using a combination of the convexity of the matrix equations, the Lyapunov functional method and the linear matrix inequality technique. It is shown via numerical examples that our developed method in the paper can lead to less conservative results than those obtained by existing methods and, furthermore, if the probability distribution of the delay occurrence is available, the allowable upper bound of the delay may be larger than those derived for the case when only the variation range of the delay can be known. Copyright © 2009 John Wiley and Sons Asia Pte Ltd and Chinese Automatic Control Society
Constrained PID tracking control for output PDFs of non‐gaussian stochastic system based on LMIs
Authors: Yi Yang , Shen Hong , Guo Lei 
Published: September 2009

AbstractThis paper presents a new PID tracking control strategy for general non‐Gaussian stochastic systems based on a square root B‐spline model for the output probability density functions (PDFs). Using the B‐spline expansion with modeling errors and the nonlinear weight model with exogenous disturbances, the PDF tracking is transformed to a constrained dynamical tracking control problem for weight vectors. Instead of the non‐convex design algorithms, the generalized PID controller structure and the improved convex linear matrix inequality (LMI) algorithms are proposed to fulfil the PDF tracking problem. Meanwhile, in order to enhance robustness, the robust peak‐to‐peak measure is applied to optimize the tracking performance. Copyright © 2009 John Wiley and Sons Asia Pte Ltd and Chinese Automatic Control Society
Adaptive output feedback control for a class of planar nonlinear systems
Authors: Shang Fang , Liu Yungang , Zhang Chenghui 
Published: September 2009

AbstractThis paper is concerned with the problem of global adaptive stabilization by output feedback for a class of planar nonlinear systems with uncertain control coefficient and unknown growth rate. The control coefficient is not supposed to have known upper bound, and this relaxes the corresponding requirement in the existing literature (see e.g. 1, 2. First, by the universal control method, an observer is constructed based on the dynamic high‐gain K‐filters. Then, the control design procedure is developed to obtain the stabilizing controller and dynamic compensator for the uncertainties in the control coefficient. It is shown that the global stability of the closed‐loop system can be guaranteed by the appropriate choice of the design parameters. A simulation example is also provided to illustrate the correctness of the theoretical results. © 2009 John Wiley and Sons Asia Pte Ltd and Chinese Automatic Control Society.
Mood and judgments based on sequential sampling
Authors: Fiedler Klaus , Renn Sven‐Yves , Kareev Yaakov 
Published: September 2009

AbstractDifferent adaptive styles characterize cognition and behavior in different affective states. Whereas negative affect supports accommodation (i.e., stimulus‐driven bottom‐up processing), positive affect supports assimilation (i.e., self‐determined top‐down processing). Applying this well‐established rule to binary choices after self‐truncated information sampling, we predicted that positive mood should render choices less dependent on large samples than negative mood. Consequently, the potential primacy advantage underlying Wald's (1947) sequential testing (i.e., quick and correct decisions from the first few items in a sample) was exploited more efficiently when participants were in positive rather than negative mood. This efficient utilization of small samples in positive mood was obtained under the very conditions derived on a priori ground from a statistical model, namely, when a response criterion or threshold was high and when the true difference between choice options was relatively small. Copyright © 2009 John Wiley & Sons, Ltd.
High‐performance liquid chromatography separation of enantiomers of mandelic acid and its analogs on a chiral stationary phase
Authors: Aneja Ritu , Luthra Pratibha Mehta , Ahuja Satinder 
Published: September 2009

AbstractThe enantiomers of mandelic acid and its analogs have been chromatographically separated on a chiral stationary phase (CSP) derived from 4‐(3,5‐dinitrobenzamido) tetrahydrophenanthrene. The rationale of separations of these compounds is discussed with respect to the method development for determining enantiomeric purity and possibility of obtaining enantiomerically pure materials by high‐pressure liquid chromatography. The relationship of analyte structure to the extent of enantiomeric separation has been examined and separation factors (α) are presented for various groups of structurally related compounds. Chiral recognition models have been suggested to account for the observed separations. These models provide mechanistic insights into the chiral recognition process. Chirality 2010. © 2009 Wiley‐Liss, Inc.
Production of (R)‐1‐phenylethanols through bioreduction of acetophenones by a new fungus isolate Trichothecium roseum
Authors: Zilbeyaz Kani , Taskin Mesut , Kurbanoglu Esabi B. , Kurbanoglu Namudar I. , Kilic Hamdullah 
Published: September 2009

AbstractA total of 120 fungal strains were isolated from soil samples and evaluated in the bioreduction of substituted acetophenones to the corresponding (R)‐alcohols. Among these strains, isolate Trichothecium roseum EBK‐18 was highly effective in the production of (R)‐alcohols with excellent enantioselectivity (ee > 99%). Gram scale preparation of (R)‐1‐phenylethanol is reported. Chirality 2010. © 2009 Wiley‐Liss, Inc.
Determination of the absolute configuration of the natural product klaivanolide via density functional calculations of vibrational circular dichroism (VCD)
Authors: Devlin Frank J. , Stephens Philip J. , Figadère Bruno 
Published: September 2009

AbstractThe absolute configuration (AC) of the antiprotozoal lactone, Klaivanolide, 1, from Uvaria klaineana, has been determined using Vibrational Circular Dichroism (VCD) spectroscopy. The experimental VCD spectrum of the (+) enantiomer of 1 was measured. To analyze the AC of (+)‐1, the conformationally‐averaged VCD spectrum of 7‐S‐1 was calculated using density functional theory (DFT) and the GAUSSIAN 03 program. The B3PW91/TZ2P conformationally‐averaged VCD spectrum of 7‐S‐1 proves that the AC of 1 is 7‐S‐(+). Chirality 21:E48–E53, 2009. © 2009 Wiley‐Liss, Inc.
Infectious Thoracic Aortitis: A Literature Review
Authors: Lopes R.J. , Almeida J. , Dias P.J. , Pinho P. , Maciel M.J. 
Published: September 2009

AbstractInfectious thoracic aortitis (IA) remains a rare disease, especially after the appearance of antibiotics. However, if left untreated it is always lethal. It usually affects patients with atherosclerotic aortic disease and/or infective endocarditis. Mycotic aneurysm is the most common form of presentation, although a few reports of nonaneurysmal infectious thoracic aortitis have also been described. Various microorganisms have been associated with infectious thoracic aortitis, most commonly Staphylococcal, Enterococcus, Streptococcus, and Salmonella species. It is extremely important to establish an early diagnosis of IA, because this condition is potentially life‐threatening. However, diagnosis is frequently delayed since clinical manifestations are usually nonspecific. Antibiotherapy in combination with complete surgical excision of the infected aorta is the best choice of treatment. Copyright © 2009 Wiley Periodicals, Inc.
The Usage Patterns of Cardiac Bedside Markers Employing Point‐of‐Care Testing for Troponin in Non‐ST‐Segment Elevation Acute Coronary Syndrome: Results from CRUSADE
Authors: Takakuwa Kevin M. , Ou Fang‐Shu , Peterson Eric D. , Pollack Charles V. , Peacock W. Frank , Hoekstra James W. , Ohman E. Magnus , Gibler W. Brian , Blomkalns Andra L. , Roe Matthew T. 
Published: September 2009

AbstractBackgroundPoint‐of‐care (POC) testing may expedite the care of emergency department (ED) patients suspected of having acute coronary syndromes (ACS). We evaluated the use patterns of cardiac bedside markers or POC testing for troponin in patients with non‐ST‐segment elevation (NSTE) ACS.MethodsNSTE ACS data were collected from the Can Rapid Risk Stratification of Unstable Angina Patients Suppress Adverse Outcomes with Early Implementation of the American College of Cardiology/American Heart Association (ACC/AHA) Guidelines (CRUSADE) registry. We compared hospital and patient characteristics, in‐hospital events, and process‐of‐care variables between hospitals to those that did not use POC testing in ≥ 50% of enrolled patients. We examined characteristics, in‐hospital events, and process‐of‐care differences between patients with negative vs positive troponin POC testing results.ResultsOf 568 hospitals, 74 (16,276 patients) had high POC usage compared with 197 hospitals (50 782 patients) with no troponin POC usage. From the high POC usage hospitals, 12 604 patients had recorded troponin POC test results. Hospitals with high POC usage had a shorter ED length of stay and were less likely to administer aspirin, β‐blockers, and heparin during the first 24 hours of care. Patients with positive troponin POC results were more often older, minority, female, Medicare‐insured, diabetic, and renally impaired. They had fewer electrocardiograms within 10 minutes but were more likely to get aspirin, β‐blockers, glycoprotein IIb/IIIa inhibitors, and heparin within 24 hours of arrival. They also had longer ED lengths of stay, received fewer in‐hospital and interventional procedures, and had more adverse clinical events.ConclusionDifferences existed in how hospitals used POC testing and the care given based on those results. Positive POC results are associated with expedited and higher use of anti‐ischemic therapies. Copyright © 2009 Wiley Periodicals, Inc.
Fluorescence‐based quantitative scratch wound healing assay demonstrating the role of MAPKAPK‐2/3 in fibroblast migration
Authors: Menon Manoj B. , Ronkina Natalia , Schwermann Jessica , Kotlyarov Alexey , Gaestel Matthias 
Published: September 2009

AbstractThe scratch wound healing assay is a sensitive method to characterize cell proliferation and migration, but it is difficult to be quantitatively evaluated. Therefore, we developed an infrared fluorescence detection‐based real‐time assay for sensitive and accurate quantification of cell migration in vitro. The method offers sensitivity, simplicity, and the potential for integration into automated large‐scale screening studies. A live cell staining lipophilic tracer—1,1′‐dioctadecyl‐3,3,3′,3′‐tetramethyl indotricarbocyanine iodide (DiR)—is used for accurate imaging of wound closure in a simple 96‐well scratch assay. Scratches are made on prestained confluent cell monolayers using a pipette tip and scanned at different time intervals using a fluorescent scanner. Images are analyzed using Image J software and the migration index is calculated. Effect of cell number, time after scratch and software settings are analyzed. The method is validated by showing concentration‐ and time‐dependent effects of cytochalasin‐D on fibroblast migration. Using this assay, we quantitatively evaluate the role of the MAPK‐activated protein kinases MK2 and MK3 in fibroblast migration. First, the migratory phenotype of MK2‐deficient MEFs is analyzed in a retroviral rescue model. In addition, migration of MK2/3‐double‐deficient cells is determined and the ability of MK3 to rescue cell migration in MK2/3‐double‐deficient fibroblasts is demonstrated. Cell Motil. Cytoskeleton 2009. © 2009 Wiley‐Liss, Inc.
Optical properties of non‐centrosymmetric mixed crystals K2(La1‐xCex)(NO3)5 · 2 H2O (x = 0.0 – 1.0)
Authors: Bohatý L. , Becker P. 
Published: September 2009

AbstractLarge single crystals of optical quality of the non‐centrosymmetric orthorhombic potassium rare earth nitrate mixed crystals K2(La1–x Cex)(NO3)5 · 2 H2O were grown at 38 °C from diluted HNO3. For crystals with x = 0.0, 0.19, 0.38 and 0.66 refractive indices and their dispersion were determined with an error less than 1 · 10–4 in the wavelength range 0.404 – 1.083 μm by the prism method. Phase matching conditions for collinear SHG frequency conversion were analysed in detail, including calculation of the effective nonlinear optical susceptibility. By an appropriate choice of the fraction x of cerium the mixed crystals K2(La1–x Cex)(NO3)5 · 2 H2O allow an adjustment of non‐critical type I phase matching conditions to a desired wavelength of the fundamental wave within the range 1.055(4) – 1.107(6) μm. Non‐critical type II phase matching can be tuned in the wavelength range 0.949(2) – 0.931(2) μm. (© 2009 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)