bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluation of non‐reductive β‐elimination/Michael addition for glycosylation site determination in mucin‐like O‐glycopeptides
Authors: Halfinger Bernhard , Sarg Bettina , Lindner Herbert H. 
Published: December 2011

AbstractInvestigation of site‐specific protein O‐glycosylation remains a formidable task in post‐translational modification‐centred proteomics. In particular, the determination of O‐glycosylated amino acids in mucin‐like glycopeptides lags far behind the techniques for phosphorylation site and N‐glycosylation site identification, for which well‐established enrichment techniques are available. The present work investigated β‐elimination of mucin‐like O‐glycopeptides with a mild alkylamine base and concomitant Michael‐type addition using 2‐mercaptoethanol as nucleophile applied to synthetic GalNAcylated O‐glycopeptides as well as exoglycosidase‐treated endogenous peptides isolated from human blood plasma. This strategy permits O‐glycosylated sites to be unambiguously localized, even in multiple‐glycosylated peptides. Peptides covalently modified with the glycan surrogate exhibit excellent backbone fragmentation in MS/MS due to their stability during CID.
Response to intra‐arterial cisplatin and concurrent radiotherapy in a patient with primary mucosal malignant melanoma of the nasal cavity
Authors: Shojaku Hideo , Takakura Hiromasa , Tachino Hirohiko , Fujisaka Michiro , Watanabe Yukio , Tomizawa Gakuto , Kawabe Hideto , Shojaku Hiroko , Seto Hikaru , Miwa Shigeharu , Fukuoka Junya , Shimizu Masashi 
Published: December 2011

AbstractBackgroundThe prognosis for patients with mucosal malignant melanoma (MMM) of the nasal cavity is very poor because of the radioresistance of melanoma cells.MethodsWe present the first case report of the efficacy of superselective intra‐arterial cisplatin (CDDP) infusion concurrent with hypofractionated radiotherapy (RT) for MMM of the nasal cavity.ResultsA pink, polypoid mass, histopathologically diagnosed as an amelanostic melanoma, occupied the right nasal cavity. After the treatment, a nasal tumor disappeared, leaving only a small bulge in the medial wall of the middle turbinate. Histopathologic examination revealed scattered degenerated melanoma cells, remaining only in the small restricted area in the medial surface of the excised middle turbinate. Twelve months after the treatment, the patient has not experienced any local recurrence or regional and distant metastasis.ConclusionsThe superselective intra‐arterial CDDP infusion concurrent with hypofractionated RT might be useful for the management of nasal MMM. © 2011 Wiley Periodicals, Inc. Head Neck, 2013
Phase I study of weekly docetaxel and cisplatin arterial infusion for recurrent head and neck cancer
Authors: Nakamura Tatsuya , Fuwa Nobukazu , Takayama Kanako , Inokuchi Haruo , Tomoda Takuya , Takada Akinori , Makita Chiyoko , Shiomi Miho , Yokouchi Jun–ichi , Watanabe Kazuo 
Published: December 2011

AbstractBackgroundWe planned a phase I study of weekly arterial infusion of docetaxel and cisplatin via a superficial temporal artery for recurrent head and neck cancer to determine the optimal dose.MethodsThe dose of cisplatin was fixed and the dose of docetaxel was escalated from 8 mg/m2, with an increase of 2 mg/m2 per step, to identify the maximum tolerated dose (MTD). In total, 4 courses of weekly chemotherapy were administered.ResultsTwelve patients were recruited to this trial. The MTD of docetaxel was 14 mg/m2. At this dose level, dose‐limiting toxicity was observed in 2 of 3 patients. One patient experienced grade 3 leukopenia, while the other experienced grade 3 leukopenia. Myelosuppression was the dose‐limiting toxicity for this regimen.ConclusionThe recommended dose for weekly arterial infusion of docetaxel was identified as 12 mg/m2 combined with weekly cisplatin at 40 mg/m2, with 4 courses of each. © 2011 Wiley Periodicals, Inc. Head Neck, 2011
Pathways of care for adolescent patients with cancer in France from 2006 to 2007
Authors: Desandes Emmanuel , Bonnay Stéphanie , Berger Claire , Brugieres Laurence , Demeocq François , Laurence Valérie , Sommelet Danièle , Tron Isabelle , Clavel Jacqueline , Lacour Brigitte 
Published: December 2011

AbstractBackgroundIn France, as in other countries, there is a need for a population‐based view of access to care and modalities of treatment for adolescents with cancer.ProcedureUsing a population‐based registration, we report pathways of care for 15–19‐year‐old patients, diagnosed with cancer in 2006 and 2007, living in six French regions, accounting for 41% of the French population.ResultsThe median times (inter‐quartile range) for diagnosis and treatment of the 594 included adolescents were 8 weeks (3–17) and 3 days (0–16), respectively. First physicians met by the patients were mostly general practitioners (59%). Seventeen percent of patients were firstly seen on emergency wards. Most of the patients (82%) were treated in an adult environment. Management decisions were taken within the context of a multi‐disciplinary team (MDT) in 54% of cases. Twenty‐seven percent of patients were included in randomized or non‐randomized clinical studies: percentage depended on the tumor type and on the number of on‐going trials at the study period. Fifteen percent of patients were included in pediatric studies, 7% in adult studies, and 5% in studies including both adults and children.ConclusionsThe pathways of care for French adolescent patients with cancer are heterogeneous. Our results reveal differences in MDT meetings according to tumor types and a lack of effective collaboration between pediatric and adult wards. Efforts must be made to develop cancer networks to ensure that adolescents receive the optimal care in a suitable environment. Pediatr Blood Cancer 2012; 58: 924–929. © 2011 Wiley Periodicals, Inc.
Effectiveness of a parent training program in (pre)adolescence: Evidence from a randomized controlled trial
Authors: Leijten Patty , Overbeek Geertjan , Janssens Jan M.A.M. 
Published: December 2011

ABSTRACTThe present randomized controlled trial examined the effectiveness of the parent training program Parents and Children Talking Together (PCTT) for parents with children in the preadolescent period who experience parenting difficulties. The program is focused on reducing child problem behavior by improving parents’ communication and problem solving skills, and disciplining behavior. Largest effects were expected for families with higher SES, and with children in mid‐adolescence. Multi‐informant and multi‐method data were used from 78 self‐referred families with children aged 9–16 (M = 13.09, SD = 1.75). Intention‐to‐treat analysis (retention rate 95%; immediate posttest only) showed that participation in PCTT significantly improved parents' communication and problem solving skills (F(1,70) = 11.77, p < 0.01 and F(1,70) = 12.87, p < 0.01), and reduced their dysfunctional disciplining behavior in conflict situations (F(1,70) = 5.25, p < .0.05). The PCTT intervention was most effective for parents with higher SES and for parents with children between the ages of 14 and 16. No consistent gender effects were found.
Spatial determinism for a freeZ2-action
Authors: BURTON ROBERT , PARK KYEWON K. 
Published: December 2011

AbstractWe extend the idea of bilateral determinism of a freeZ-action by D. Ornstein and B. Weiss to a freeZ2-action. We show that we have a ‘stronger’ spatial determinism forZ2-actions: to determine the completeZ2-name of a point, it is enough to know the name of a fraction of the orbit whose density can be made arbitrarily small. Moreover, for zero-entropyZ2-actions, we prove that there exists a partition$\tilde {\mathcal {P}}$such that the$\tilde {\mathcal {P}}$-names of an arbitrarily small one-sided cone determine the points.
Preservice Efforts To Promote School-Based SLPs' Roles in Written Language Development
Authors: Lanter Elizabeth , Waldron Claire 
Published: December 2011

AbstractThe authors describe an innovative clinical education program that emphasizes the provision of written language services by preservice speech-language pathology graduate students at Radford University in Virginia. Clinicians combined academic coursework in language acquisition in school-age children and clinical experiences that target children's written language development to promote future literacy-based leadership roles and collaborative efforts among school-based speech-language pathologists (SLPs). These literacy-based experiences prepare SLPs to serve in the growing numbers of American public schools that are implementing Response to Intervention models.
Collaborative behavioral management among parolees: drug use, crime and re‐arrest in the Step'n Out randomized trial
Authors: Friedmann Peter D. , Green Traci C. , Taxman Faye S. , Harrington Magdalena , Rhodes Anne G. , Katz Elizabeth , O'Connell Daniel , Martin Steven S. , Frisman Linda K. , Litt Mark , Burdon William , Clarke Jennifer G. , Fletcher Bennett W. ,   the Step'n Out Research Group of CJ‐DATS
Published: December 2011

ABSTRACTAims  To determine whether collaborative behavioral management (CBM) reduces substance use, crime and re‐arrest among drug‐involved parolees.Design  Step'n Out was a randomized behavioral trial of CBM versus standard parole (SP) during 2004–08. CBM adapted evidence‐based role induction, behavioral contracting and contingent reinforcement to provide parole officer/treatment counselor dyads with positive tools in addition to sanctions to manage parolees' behavior over 12 weeks.Setting  Six parole offices in five states in the USA.Participants  Parolee volunteers with a mandate for addiction treatment and a minimum of 3 months of parole (n = 476). Follow‐up was 94% at 3 months and 86% at 9 months.Measurements  Drug use and crime in a given month from calendar interviews 3 and 9 months after parole initiation, and re‐arrests from criminal justice administrative data.Findings  The CBM group had fewer months in which they used their primary drug [adjusted risk ratio (ARR) 0.20, 95% confidence interval (CI): 0.05, 0.78, P = 0.02] and alcohol (ARR 0.38, 95% CI: 0.22, 0.66, P = 0.006) over follow‐up. CBM had its greatest effects among parolees who reported marijuana or another ‘non‐hard’ drug as their primary drug; parolees who preferred stimulants or opiates did not benefit. No differences were seen in total crime, re‐arrests or parole revocations.Conclusions  Collaborative behavioral management may reduce substance use among primary marijuana or other ‘non‐hard’ drug‐using parolees without increasing revocations. Because the majority of drug violation arrests in the United States are for marijuana, these findings have important implications for the management of a substantial proportion of the US community correctional population.
Experimental diabetes treated with trigonelline: effect on β cell and pancreatic oxidative parameters
Authors: Zhou Jiyin , Zhou Shiwen , Zeng Shengya 
Published: December 2011

AbstractOxidative stress in diabetes coexists with a reduction in the antioxidant status, which can further increase the deleterious effects of free radicals. Trigonelline is the major component of Mirabilis jalapa L., which has been used to treat diabetes in China. The present study was designed to evaluate the beneficial effects of trigonelline against hyperglycemia, hyperlipidemia, β cell damage and antioxidant of pancreas in diabetic rats. Diabetic rats were induced by intraperitoneal injection 35 mg/kg streptozotocin and a high‐carbohydrate/high‐fat diet. Rats were divided into four groups: normal control, diabetic control, trigonelline‐treated diabetic, and glibenclamide‐treated diabetic. After 4‐week treatment, blood glucose, serum insulin, total cholesterol (TC), and triglyceride (TG) levels, insulin content in pancreas, and oxidative stress parameters in pancreatic homogenate were assayed. Pancreas was examined by hematoxylin/eosin staining. Trigonelline significantly decreased blood glucose, TC, and TG levels of diabetic rats. Pancreas‐to‐body weight ratio, insulin level, insulin sensitivity index, insulin content in pancreas, malonaldehyde and nitric oxide contents, and superoxide dismutase, catalase, glutathione and inducible nitric oxide synthase activities were altered in diabetic rats, and were near control levels treated with trigonelline. These findings suggest that trigonelline has beneficial effect for diabetes through decreasing blood glucose and lipid levels, increasing insulin sensitivity index and insulin content, up‐regulating antioxidant enzyme activity and decreasing lipid peroxidation.
Long‐term motor and cognitive outcome in children with congenital diaphragmatic hernia
Authors: Tureczek Isabell , Caflisch Jon , Moehrlen Ulrich , Natalucci Giancarlo , Bernet Vera , Latal Beatrice 
Published: December 2011

AbstractAims:  To determine the motor and cognitive outcome in a regional cohort of survivors of surgically corrected congenital diaphragmatic hernia.Methods:  Thirty‐three children (85% of survivors) were examined at a mean age of 8.6 years (3.3–15.7 years), seven had a genetic comorbidity. Outcome was assessed with the Wechsler Preschool and Primary Scale of Intelligence 3rd version and the Wechsler Intelligence Scale 4th version. Motor performance was tested with the Movement Assessment Battery for Children 2nd edition in children younger than 5 years and thereafter with the Zurich Neuromotor Assessment.Results:  Children without a genetic comorbidity had a normal cognitive outcome (median IQ 103, 70–121), but fine motor (p = 0.008) and gross motor outcome (p = 0.001) were poorer than the norm. Medical variables were not predictive of adverse outcome, whereas genetic comorbidity was the strongest predictor of low IQ (p < 0.001) and of poor motor performance (p = 0.04).Conclusions:  In the absence of a genetic comorbidity, children with congenital diaphragmatic hernia have a favourable cognitive outcome, but motor outcome may be affected. This needs to be taken into account for parental counselling. Further, long‐term neurodevelopmental assessment in children with congenital diaphragmatic hernia is important to provide early therapeutic interventions.
A Novel Type of Dental Tube Implant for Areas with Limited Bone Height. Clinical and Radiographic Data from Three Patients with 5‐Year Follow‐Up
Authors: Lundgren Dan , Slotte Christer , Gröndahl Kerstin 
Published: December 2011

ABSTRACTBackground: Alternative implant designs may reduce the need for complicated and costly bone augmentation procedures in situations with limited bone height.Purpose: Wide dental tube implants have been manufactured and tested in three patients and followed for 5 years to evaluate if such implants are capable to support fixed prosthetic constructions with good prognosis in areas with limited bone height.Materials and Methods: Four machined‐tube implants with a height of 6 mm, an outer diameter of 7.4 mm, and an inner diameter of 6.0 mm were placed in three patients. After a healing period of 3 months, ceramometal suprastructures were constructed to supply the implants. Annual clinical and radiographical follow‐ups were done up to 5 years. At the 5‐year follow‐up, all three patients were examined with a cone beam computed tomography technique.Results: All implants and the suprastructures were clinically stable after 5 years. In one patient, vertical bone loss and a 6‐mm deep pocket appeared after 1 year. The pocket has remained throughout the observation period and has been regularly debrided and kept it free from clinical signs of inflammation. In the other two patients, the soft tissue surrounding the implants was in good health with no or only slight inflammation throughout all observations. Pocket probing revealed no or slight bleeding and pocket depths amounting to less than 3 mm.Conclusion: It was shown that this new type of implant will function excellent during follow‐up times of several years. Further studies should be done to explore in more detail indications for such implants.
Healing of Fresh Frozen Bone Allograft with or without Platelet‐Rich Plasma: A Histologic and Histometric Study in Rats
Authors: Messora Michel , Braga Laís , Oliveira Gabriela , Oliveira Luiz Fernando , Milagres Roselaine , Kawata Leandro , Furlaneto Flávia , Pola Natália , Campos Natália , Nagata Maria 
Published: December 2011

ABSTRACTPurpose: This study histomorphometrically analyzed the effect of autogenous platelet‐rich plasma (PRP) on healing of fresh frozen bone allograft (FFBA) in bony defects in rat calvaria.Materials and Methods: A 5 mm–diameter defect was created in the calvarium of 30 rats. Animals were divided into three groups: C (defect was filled by blood clot only), FFBA (defect was filled with 0.01 mL of FFBA), and FFBA/PRP (defect was filled with 0.01 mL of FFBA combined with 100 µL of PRP). All animals were euthanized at 30 days postoperatively. Histomorphometry and histology analyses were performed. Data were statistically analyzed (analysis of variance, Tukey, p < .05).Results: FFBA had a statistically smaller new bone area than groups FFBA/PRP and C. No statistically significant differences were observed between groups FFBA and FFBA/PRP with regard to remaining bone graft particle area.Conclusion: It can be concluded that (1) PRP improved the incorporation of FFBA, increasing the amount of new bone formed; (2) PRP has not influenced the resorption of nonviable particles of the FFBA; and (3) presence of remaining FFBA particles might have accounted for the smaller amount of new bone observed in group FFBA when compared with control group.
Osteotome Maxillary Sinus Lift Using Bovine Bone and Calcium Sulfate: A Case Series
Authors: AlGhamdi Ali Saad Thafeed 
Published: December 2011

ABSTRACTPurpose: The purpose of this longitudinal study was to evaluate the success of bovine bone and calcium sulfate (CaSO4) as sinus augmentation material with osteotome maxillary sinus lift.Materials and Methods: Thirty‐one osteotome sinus lift procedures were performed for 18 healthy patients (7 males and 11 females). A mixture of bovine bone and CaSO4 (ratio, 4:1) was used as sinus augmentation material with simultaneous implant placement. Implants were loaded 4 to 5 months postimplant surgery. Cases were followed for an average of 23.4 months postloading (range, 12–60 months).Results: The mean age of the study group was 49.7 ± 10.66 years. The residual height of the alveolar ridge ranged from 5.5 to 11 mm (mean, 8.16 ± 1.52 mm). Four to 5 months after implant placement, the x‐ray showed a 1.5 to 5 mm apical shift of the sinus floor (mean, 3.47 ± 0.97 mm), which was maintained to the end of the evaluation period. At 12 months postloading, crestal bone loss ranged from 0.5 to 1.5 mm (mean, 0.87 ± 0.26 mm), and pocket depth ranged from 2 to 4 mm (mean, 2.9 ± 0.67 mm). No significant change in crestal bone loss or pocket depth was noticed afterward.Conclusion: Bovine bone plus CaSO4 can be used successfully as a sinus augmentation material with osteotome sinus elevation. The use of CaSO4 significantly improved the handling properties of bovine bone and helped to stabilize the bone graft particles during healing.
Influence of Preparation and Wall Thickness on the Resistance to Fracture of Zirconia Implant Abutments
Authors: Att Wael , Yajima Nao‐Daniel , Wolkewitz Martin , Witkowski Siegbert , Strub Joerg Rudolf 
Published: December 2011

ABSTRACTBackground: Studies about the effect of grinding procedures as well as material thickness on the resistance of zirconia implant abutments are in short supply.Purpose: This study evaluated the effect of wall thickness as well as preparation on the resistance of zirconia implant abutments.Materials and Method: Sixty‐four implants received titanium (group Ti) and zirconia abutments (groups Zr‐8, Zr‐18, and Zr‐1). The abutments of group Zr‐8 had a 0.8‐mm wall thickness, whereas the wall thickness of group Zr‐18 was reduced by preparation from 1 mm to 0.8 mm. The abutments of group Zr‐1 had a wall thickness of 1 mm. Standardized maxillary central incisor metal crowns were cemented on all abutments. All specimens were then tested in a universal testing machine for their resistance to fracture before and after masticatory simulation (n = 8).Results: The median resistance to fracture values (N) before and after aging were, respectively: group Ti: 500–504; group Zr‐8: 487–491; group Zr‐18: 490‐451; and group Zr‐1: 519‐480. No significant effects of group, aging, or combinations were found (p > .05).Conclusion: All tested abutments have the potential to withstand physiologic occlusal forces in the anterior region (>200 N). The applicability of the results to other implant systems should be verified.
Use of food labels, awareness of nutritional programmes and participation in the special supplemental program for Women, Infants and Children (WIC): results from the National Health and Nutrition Examination Survey (2005–2006)
Authors: Wojcicki Janet M. , Heyman Melvin B. 
Published: December 2011

AbstractUse of nutritional labels in choosing food is associated with healthier eating habits including lower fat intake. Current public health efforts are focusing on the revamping of nutritional labels to make them easier to read and use for the consumer. The study aims to assess the frequency of use of nutritional labels and awareness of the United States Department of Agriculture (USDA) nutritional programmes by low‐income women including those participating in the Special Supplemental Nutrition Program for Women, Infants and Children (WIC) as surveyed in the National Health and Nutrition Examination Survey 2005–2006. Many low‐income women do not regularly use the nutrition facts panel information on the food label and less than half had heard of the USDA Dietary Guidelines for Americans (38.9%). In multivariate logistic regression, we found that WIC participation was associated with reduced use of the nutrition facts panel in choosing food products [odds ratio (OR) 0.45, 95% confidence interval (CI) 0.22–0.91], the health claims information (OR 0.54, 95% CI 0.32–0.28) and the information on carbohydrates when deciding to buy a product (OR 0.44, 95% CI 0.20–0.97) in comparison with WIC eligible non‐participants. Any intervention to improve use of nutritional labels and knowledge of the USDA's nutritional programmes needs to target low‐income women, including WIC participants. Future studies should evaluate possible reasons for the low use of nutrition labels among WIC participants in comparison with eligible non‐participants.