bluuebunny/crossref_metadata_2025_split huggingface dataset:
ChemInform Abstract: The NHCs‐Mediated Cross‐Coupling of Aromatic Aldehydes with Benzyl Halides: Synthesis of α‐Aryl Ketones.
Authors: Lin Lu , Li Yi , Du Wenting , Deng Wei‐Ping 
Published: September 2010

AbstractThe optimized conditions render possible the preparation of various synthetically important title compounds in moderate yields when benzyl bromides are used.
ChemInform Abstract: One‐Pot Conversion of Aromatic Bromides and Aromatics into Aromatic Nitriles.
Authors: Ushijima Sousuke , Togo Hideo 
Published: September 2010

AbstractVarious bromoarenes and p‐iodotoluene can be efficiently converted to nitriles through a one‐pot sequence including lithiation, reaction with DMF and subsequent oxidation with iodine in the presence of ammonia.
ChemInform Abstract: Platinum‐Catalyzed Cycloisomerization of 1,4‐Enynes via Activation of a sp3‐Hybridized C—H Bond.
Authors: Vasu Dhananjayan , Das Arindam , Liu Rai‐Shung 
Published: September 2010

AbstractThe cycloisomerization of 1‐alkenyl‐1‐alkynylcyclopropanes (I) and (III) to cyclooctatriene derivatives (II) and (IV) is reported.
ChemInform Abstract: Enantioselective Friedel—Crafts Alkylation Reaction of Indoles with α,β‐Unsaturated Acyl Phosphonates Catalyzed by Chiral Phosphoric Acid.
Authors: Bachu Prabhakar , Akiyama Takahiko 
Published: September 2010

AbstractA variety of indoles (I) undergo enantioselective Friedel—Crafts alkylation with α,β‐unsaturated acyl phosphonates (II) and (V) in the presence of a BINOL‐derived phosphoric acid.
ChemInform Abstract: Synthesis and Antibacterial Activity of a Novel Series of 2,3‐Diaryl‐substituted‐imidazo(2,1‐b)‐benzothiazole Derivatives.
Authors: Palkar Mahesh , Noolvi Malleshappa , Sankangoud Ramappa , Maddi Veeresh , Gadad Andanappa , Nargund Laxmi Venkat G. 
Published: September 2010

AbstractTitle compounds (III) are obtained after modification of a previously reported method.
ChemInform Abstract: Organic Synthesis Using a Hypervalent Iodine Reagent: Unexpected and Novel Domino Reaction Leading to Spiro Cyclohexadienone Lactones.
Authors: Fujioka Hiromichi , Komatsu Hideyuki , Nakamura Taeko , Miyoshi Akihito , Hata Kayoko , Ganesh Jnashuara , Murai Kenichi , Kita Yasuyuki 
Published: September 2010

AbstractA novel transformation of phenols bearing a benzylic tert‐alcohol moiety, e.g. (I) and (III) is described.
ChemInform Abstract: Direct Catalytic Benzylation of Hydroxycoumarin — Efficient Synthesis of Warfarin Derivatives and Analogues.
Authors: Rueping Magnus , Nachtsheim Boris J. , Sugiono Erli 
Published: September 2010

AbstractA benzylation procedure for 4‐hydroxycoumarin is developed for the synthesis of substituted analogues of warfarin (XII) using Bi(OTf)3 as inexpensive catalyst.
ChemInform Abstract: Imino Diels—Alder Reactions: One‐Pot Synthesis of Tetrahydroquinolines.
Authors: Kamble Vinod T. , Davane Bhaskar S. , Chavan Sanjay A. , Muley Dnyanoba B. , Atkore Sandeep T. 
Published: September 2010

AbstractThe three‐component coupling proceeds within short reaction times.
ChemInform Abstract: Synthesis and Primary Anticonvulsant Activity Evaluation of 6‐Alkyoxyl‐tetrazolo[5,1‐a]phthalazine Derivatives.
Authors: Sun Xian‐Yu , Wei Cheng‐Xi , Deng Xian‐Qing , Sun Zhi‐Gang , Quan Zhe‐Shan 
Published: September 2010

AbstractTitle compounds (V), synthesized starting from dichlorophthalazine (I), are found to exhibit anticonvulsant activity.
ChemInform Abstract: Rod‐Like Conjugated Molecules with Ethynylene Linkage and Pyridazine Moieties: Synthesis and Light Emitting Properties.
Authors: Hadad Caroline , Fiol‐Petit Catherine , Cornec Anne‐Sophie , Dupas Georges , Ramondenc Yvan , Ple Nelly 
Published: September 2010

AbstractA series of title compounds are prepared using Sonogashira cross‐coupling and condensation reactions.
ChemInform Abstract: Tri(t‐butyl)phosphine‐Assisted Selective Hydrosilylation of Terminal Alkynes.
Authors: Wu Wei , Zhang Xiao Yun , Kang Shou Xing , Gao Yan Min 
Published: September 2010

AbstractPure (E)‐ or α‐products are obtained exclusively depending on the alkynes and silanes used.
ChemInform Abstract: Regioselective Synthesis of Highly Functionalized Arylphosphonates by Cyclocondensation of 1,3‐Bis(trimethylsilyloxy)buta‐1,3‐dienes with 3‐Ethoxy‐2‐phosphonylalk‐2‐en‐1‐ones.
Authors: Fatunsin Olumide , Shkoor Mohanand , Riahi Abdolmajid , Langer Peter 
Published: September 2010

AbstractIt is important for the process to work with a highly concentrated solution of phosphonates (II).
ChemInform Abstract: Borostannylation of Alkynes and Enynes. Scope and Limitations of the Reaction and Utility of the Adducts.
Authors: Singidi Ramakrishna Reddy , RajanBabu T. V. 
Published: September 2010

AbstractThe Pd‐catalyzed reaction with the hetero‐bismetallating reagent (I) gives hydrolytically instable intermediates which are directly converted to stable boron pinacolates.
ChemInform Abstract: Determination of the Structure and Its Absolute Configuration of 2′′‐Hydroxynicotianamine, an Inhibitor Against Angiotensin‐I Converting Enzyme in Buckwheat, Through the Total Synthesis.
Authors: Yoshikawa Keisuke , Watanabe Hidenori , Aoyagi Yasuo , Kitahara Takeshi 
Published: September 2010

AbstractThe absolute configuration of 2′′‐hydroxynicotianamine (I), an inhibitor against angiotensin‐I converting enzyme, is determined by an enantioselective synthesis.
Glass Microreactors for Laboratory Application
Authors: Dubnack K. , Körsten S. , Kreisel G. , Frank T. 
Published: September 2010

AbstractDie Einführung der Mikroreaktionstechnik in die Forschungslaboratorien und Praktika der Hochschulen erfordert kostengünstige und einfach handhabbare mikrostrukturierte Apparaturen. Mikromischer und ‐verweiler aus Glas sind eine Alternative zu Rundkolben in der chemischen Synthese. Die Integration in vorhandene Aufbauten ist durch die Verwendung standardisierter Anschlüsse und vertrauter Labortechniken gewährleistet.
Pulverization of high‐viscosity liquids
Authors: Haensel M. , Voigt J. , Grüner‐Richter S. , Sommer K. , Lopez S. , Kilzer A. , Weidner E. 
Published: September 2010

AbstractHochviskose Zuckerlösungen liegen nach einer Pulverisierung größtenteils amorph vor und sind damit stark hygroskopisch. Eine Pulverisierung wird dennoch angestrebt, da sich diese Flüssigkeiten durch ihre hohe Viskosität nur schlecht dosieren oder mit anderen Pulvern mischen lassen. Es wird dargestellt, mit welchen Verfahren zum einen qualitativ hochwertige Pulver hergestellt werden können und zum anderen die Hygroskopizität umgangen werden kann.
Asymmetric Hydrogenation of Cyclic N‐Sulfonylimines with Phosphine‐Free Chiral Cationic Ru‐MsDPEN Catalysts
Authors: Chen Fei , Li Zhiwei , He Yanmei , Fan Qinghua 
Published: September 2010

AbstractPhosphine‐free chiral cationic Ru/diamine complexes are effective catalysts for the asymmetric hydrogenation of a range of cyclic N‐sulfonylimines, affording chiral sultam derivatives with good to excellent enantioselectivity (up to 94% ee).
A Tandem Intramolecular Michael Addition/Wittig Reaction for the Synthesis of Fused Cyclohexadiene Derivatives
Authors: Wang Qinggang , Sun Xiuli , Zheng Juncheng , Tang Yong 
Published: September 2010

AbstractA tandem intramolecular Michael addition/Wittig reaction has been developed for the synthesis of fused cyclohexadiene derivatives from phosphonium salt 3. This annulation reaction affords the cyclohexadienes in moderate to excellent yields, depending on the substrates. A mechanism is proposed to account for the tandem process.
A General and Facile Approach for the Synthesis of 2′‐Functionalized 1,1′‐Binapthyl‐2‐ols
Authors: Xie Xiaomin , Ding Lina , Ni Gang , Zhang Zhaoguo , Gao Jinsheng 
Published: September 2010

AbstractA facile and efficient protocol for the synthesis of 2′‐functionalized 1,1′‐binaphthyl‐2‐ols has been developed. The C,O‐dilithio reagent (2) generated by the reductive ring‐opening of binaphthofuran (1) with lithium was treated with the corresponding electrophiles to give 2′‐functionalized 1,1′‐binaphthyl‐2‐ols including the halides (3), amine (4), acid (5), aldehyde (6), carbonate (7) or phosphonate (8), respectively, in moderate to good yields.
Electrocarboxylation of Alkynes with Carbon Dioxide in the Presence of Metal Salt Catalysts
Authors: Li Chuanhua , Yuan Gaoqing , Jiang Huanfeng 
Published: September 2010

AbstractWith some common metal salts (CuI, FeCl3) as catalysts, alkynes can be effectively electrocarboxylated with CO2 (4 MPa) in an undivided cell with Ni cathode and Al sacrificial anode containing n‐Bu4NBr‐DMF as supporting electrolyte with a constant current at room temperature. The saturated tricarboxylic acids besides the dicarboxylic acids were obtained in good yields. The yields of the tricarboxylic acids were strongly influenced by various metal salt catalysts, cathode materials and the property of substituted groups. Finally, the possible electrochemical mechanism was discussed.
Using Chemical Derivatization to Determine the Human Urinary Acidic Catecholamine Metabolites Quantitatively by Liquid Chromatography/Electrospray Ionization‐Tandem Mass Spectrometry
Authors: Gao Yuping , Zhang Jing , Zhang Li , Guo Yinlong 
Published: September 2010

AbstractBased on a 4,6‐dimethoxy‐2‐(methylsulfonyl)pyrimidine (DMMSP) labeling reagent, a sensitive method to determine acidic catecholamine metabolites homovanillic acid (HVA), vanillymandelic acid (VMA), 3,4‐dihydroxymandelic acid (DOMA) and 3,4‐dihydroxyphenylacetic acid (DOPAC) has been developed using simple chemical derivatization with liquid chromatography/electrospray ionization‐tandem mass spectrometry (LC/ESI‐MS/MS). Acidic catecholamine metabolites were converted to stable 4,6‐dimethoxypyrimidinyl (DMP) derivatives by one‐step derivatization. Because of bulky DMP group(s) introduced into the structures of these metabolites, subsequent analysis by LC/ESI‐MS/MS in positive ionization with multiple reaction monitoring (MRM) allowed specific detection of DMP derivatives of these metabolites with a wide linear relationship range. The limits of detection were in the range of 1–5 ng/mL. The mean recoveries determined were 100.2% –104.4%. Both relative standard deviation and error for intra‐ and inter‐day measurements were less than 10% for acidic catecholamine metabolites. This strategy enabled accurate and specific determination of acidic catecholamine metabolites in human urine.
Asymmetric Hydrogenation of Unfunctionalized Enamines Catalyzed by Iridium Complexes of Chiral Spiro N,N‐Diarylphosphoramidites
Authors: Yan Pucha , Xie Jianhua , Zhou Qilin 
Published: September 2010

AbstractChiral spiro N,N‐diarylphosphoramidites were synthesized. These new chiral spiro monophosphoramidites were efficient ligands for iridium‐catalyzed asymmetric hydrogenation of unfunctionalized enamines derived from simple alkyl aryl ketones, providing chiral tertiary amines in good enantioselectivities (up to 90% ee).
Association of diffuse, random pulmonary metastases, including miliary metastases, with epidermal growth factor receptor mutations in lung adenocarcinoma
Authors: Togashi Yosuke , Masago Katsuhiro , Kubo Takeshi , Sakamori Yuichi , Kim Young Hak , Hatachi Yukimasa , Fukuhara Akiko , Mio Tadashi , Togashi Kaori , Mishima Michiaki 
Published: September 2010

AbstractBACKGROUND:Although the association of multiple pulmonary metastases, and particularly miliary metastases, with response to gefitinib treatment in patients with nonsmall cell lung cancer has been reported, the association of miliary pulmonary metastases with epidermal growth factor receptor gene (EGFR) mutations remains unclear.METHODS:The authors retrospectively investigated the association of diffuse, random pulmonary metastases in patients with lung adenocarcinoma. The study included 163 Japanese patients who had unresectable, advanced lung adenocarcinoma diagnosed between April 2003 and March 2010. Computed tomography scans that were obtained at the time of diagnosis were analyzed by 2 investigators. For the purposes of this study, diffuse, random pulmonary metastases were defined as multiple nodules (n = 50; ≤3 cm in greatest dimension) distributed diffusely and randomly throughout the lungs.RESULTS:Of 163 patients, 55 had pulmonary metastases, and EGFR mutations were detected in 22 of those 55 patients. The mutations were identified preferentially among women (P = .15) and were identified significantly among patients who had a smoking history of <10 pack‐years (P = .0057). Diffuse, random pulmonary metastases were identified in 11 of 22 patients who had EGFR mutations and in 4 of 33 patients who had the wild‐type EGFR (P = .0043). On the basis of multivariate analyses, EGFR mutations were associated independently with a smoking history of <10 pack‐years (P = .026) and with diffuse, random pulmonary metastases (P = .012).CONCLUSIONS:When patients with lung adenocarcinomas who had EGFR mutations developed pulmonary metastases, they tended to be diffuse and random, including military metastases. However, such metastases were much less common in patients who had lung adenocarcinomas with wild‐type EGFR. Cancer 2011. © 2010 American Cancer Society.
Towards Fast Measurement of the Electron Temperature in the SOL of ASDEX Upgrade Using Swept Langmuir Probes
Authors: Müller H.W. , Adamek J. , Horacek J. , Ionita C. , Mehlmann F. , Rohde V. , Schrittwieser R. , ASDEX Upgrade Team  
Published: September 2010

AbstractOn ASDEX Upgrade first experiments were made using single probes with a voltage sweep frequency up to 100kHz. Possibilities and limitations using fast swept probes with a standard diagnostic and analysis tools are discussed. A good agreement between the data derived from fast swept single probe characteristics and floating as well as saturation current measurements was found. In a stationary (non ELMing) plasma the data of the fast swept probe are compared to standard slow swept probes (kHz range) showing an improvement of the measurement by faster sweeping. While ELM filaments already could be resolved the access of electron temperature fluctuations in small scale turbulence still has to be improved. Further comparisons are done in ELMy H‐mode with combined ball‐pen probe/floating potential measurements which can deliver electron temperatures with 25 μ s time resolution at reduced spatial resolution compared to pin probes. During ELMs the electron temperatures derived from the ball‐pen probe and fast swept single probes agreed (© 2010 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Spatial Distribution of Plasma Parameters in DC‐Energized Hollow Cathode Plasma Jet
Authors: Leshkov S. , Kudrna P. , Chichina M. , Klusoň J. , Picková I. , Virostko P. , Hubička Z. , Tichý M. 
Published: September 2010

AbstractDC energized hollow cathode plasma jet system was examined by radially movable Langmuir probe. Radial distribution of electron concentration, plasma and floating potentials and mean electron energy were obtained from measured probe characteristics at the distance 17 mm downstream of the hollow cathode – nozzle. The radial dependence of plasma parameters was measured for distances from the system axis 0–120 mm in the discharge containing Ar and O2. Two scenarios were used: addition of O2 into the nozzle and into the plasma vessel. The differences in measured floating and plasma potential, electron density and mean electron energy radial courses obtained in the two scenarios are qualitatively explained. In addition temporal dependences of main plasma parameters for discharges in clean argon and argon‐oxygen mixture were investigated that demonstrate system stability and its applicability for deposition of layers containing Ti.TiOx thin films were deposited onto glass substrates and examined by AFM and ellipsometry. It is illustrated that the differences in plasma parameters in the two scenarios of oxygen addition influence the layer properties (© 2010 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Nitric oxide‐mediated augmentation of neutrophil reactive oxygen and nitrogen species formation: Critical use of probes
Authors: Kumar Sachin , Patel Satyananda , Jyoti Anupam , Keshari Ravi Shankar , Verma Anupam , Barthwal Manoj Kumar , Dikshit Madhu 
Published: September 2010

AbstractPrevious reports from this laboratory and others demonstrated NO‐mediated biphasic modulation of NADPH oxidase and attenuation of neutrophil reactive oxygen species generation, whereas recently we reported augmentation in DCF fluorescence following NO treatment. These discrepancies seem to be due to utilization of different probes/methods to assess effect of NO on reactive oxygen and nitrogen species (ROS/RNS, reactive species) generation. This study aims to look into this and evaluate NO‐mediated enzymatic reactive species formation by using multiple probes, human neutrophils/HL60 cells and various interventions. Addition of NO donor, SNP or SNAP (100 nM–1 mM) to PMNs suspension, exhibited a concentration‐ and time‐dependent augmentation in DCF fluorescence, but reduced DHE fluorescence. Collective generation of reactive species was confirmed by enhanced DMPO‐nitrone adduct, dityrosine and rhodamine‐123 and quenching of scopoletin. NO also enhanced bacterial killing, without altering phagocytosis. Addition of NO to HL‐60 cells lacking functional NADPH oxidase enhanced reactive species formation, indicating importance of other enzyme(s) too. NO‐dependent ROS/RNS generation was substantially reduced by NADPH oxidase inhibitor (DPI), MPO inhibitor (ABAH), or NOS inhibitor (7‐NI). However, 7‐NI reduced MPO activity, warranting reappraisal of those reports, which implied NOS in reactive species formation. The results obtained demonstrated NO‐mediated reactive species augmentation in human PMNs. Furthermore, superoxide scavenging by NO seems to be the key process in the decrease of DHE fluorescence and suggest usefulness of DCF as the most appropriate probe to measure the NO‐mediated modulation of reactive oxygen species in particular in various pathological situations. © 2010 International Society for Advancement of Cytometry
Metabolic limitations of the use of nucleoside analogs in cancer therapy may be overcome by application of nanoparticles as drug carriers: A review
Authors: Hajdo Lukasz , Szulc Aleksandra Beata , Klajnert Barbara , Bryszewska Maria 
Published: September 2010

AbstractPurine and pyrimidine nucleoside analogs (NAs) are antimetabolites commonly used in cancer therapy. Administered as prodrugs, NAs permeate the mambrane using specialized transporters. Following phosphorylation, they interfere with multiple cellular pocessess inducing cytotoxicity. Toxic effects of NAs are dependent on metabolic conversion from a prodrug into the active form. For instance, an exceptionally high activity of deoxycytidine kinase (dCK) in lymphocytes is correlated with a good therapeutic effect of fludarabine in leukemic cells. On the other hand, several studies have shown that nucleoside‐transporter (NT)‐deficient‐cells are highly resistant to NAs. Attempts to overcome the metabolic limitations of chemotherapeutics would result in the use of lower drug doses for effective therapy, reduce side effects, and ensure the independence of drug resistance mechanisms. To meet this need, several nanoparticles have been designed to deliver efficently NAs directly to cancer cells. Such vehicles include liposomes, albumins, and dendritic and linear polymers. Therapeutic agents encapsulated or conjugated to nanoparticles have improved pharmacokinetics, solubility, and stability. These factors improve the efficacy of commonly used drugs. Moreover, modification of nanoparticles with targeting molecules such as sugar moieties or folic acid ensures more specific delivery without affecting healthy tissues. Drug Dev Res 71: 383–394, 2010. © 2010 Wiley‐Liss, Inc.
Dynamics of sleep–wake cyclicity across the fetal period in sheep (Ovis aries)
Authors: Karlsson K.Æ. , Arnardóttir H. , Robinson S.R. , Blumberg M.S. 
Published: September 2010

AbstractAll adult mammals examined thus far exhibit sleep bout durations that follow an exponential distribution and wake bout durations that follow a power‐law distribution. In altricial rodents such as rats and mice, exponential distributions of sleep bouts are found soon after birth, but the power‐law distribution of wake bouts does not emerge until the third postnatal week. Also, both sleep and bouts consolidate across the early postnatal period. It is not known whether similar developmental processes occur in precocial species during the prenatal period. Here we characterize sleep–wake development in a precocial species, the domestic sheep (Ovis aries), from 114 to 148 days gestational age (DGA). Sleep and wake bout durations exhibited exponential distributions throughout the fetal period with some evidence of an emerging exponential‐to‐power‐law transition for wake bouts toward the end of gestation. Both sleep and wake bouts consolidated in an orderly fashion across development and there was little evidence of circadian variation, even in the oldest subjects. These results indicate that similar patterns of sleep–wake organization are found prenatally in a precocial species as are found postnatally in altricial species. Data from more species are needed to fully realize the benefits of a developmental comparative approach for understanding the forces that have shaped the ontogeny and phylogeny of mammalian sleep. © 2010 Wiley Periodicals, Inc. Dev Psychobiol 53: 89–95, 2011.
Development of trouble diagnosis technology of 50‐W‐grade micro wind turbine generator
Authors: Takaoka Masashige , Inohata Kazuki , Miyake Takuma , Tashima Daisuke , Otsubo Masahisa , Bouno Toshio 
Published: September 2010

AbstractThe establishment of an early trouble diagnosis system is needed in order to prevent damage to wind turbine generators. Therefore, acoustic emission (AE) signals resulting from damage to a wind blade were detected with an AE sensor installed on the body of the wind turbine generator and on the mounting pole. In this study, the length of a blade of a micro wind turbine generator was varied to simulate trouble at constant wind velocity. The AE signals which occurred at this time were measured with an AE sensor. The signal was processed by FFT analysis, and the change of spectral strength was examined. A trouble diagnosis technology for 50‐W‐grade micro wind turbines generator was then developed. A method of counting the number of occurrences of above‐threshold AE signals was suggested by the wave pattern of the AE signals. It was found that the number of occurrences could be used as a standard to judge the normality or abnormality of 50‐W‐grade micro wind turbine generators. © 2010 Wiley Periodicals, Inc. Electr Eng Jpn, 174(1): 33–39, 2011; Published online in Wiley Online Library (wileyonlinelibrary.com). DOI 10.1002/eej.21017
Multi‐agent cooperative voltage and reactive power control
Authors: Nagata Takeshi , Saeki Hiroshi , Utatani Masahiro , Nakachi Yoshiki , Hatano Ryousuke 
Published: September 2010

AbstractDistributed generation is emerging as a new alternative for power generation at a smaller but distributed scale. The output of distributed generators (DGs) depends mainly on weather conditions. On the other hand, the electric utility industry worldwide has been facing pressure for deregulation. The power flow in the electric power market will vary uncertainly with several power transactions. Therefore, complex power flow due to DGs or transactions will cause voltage deviations. To avoid these undesirable phenomena, we propose a new multi‐agent method for cooperative voltage control. The simulation results show that the proposed multi‐agent method performs better than a conventional control method. © 2010 Wiley Periodicals, Inc. Electr Eng Jpn, 174(1): 25–32, 2011; Published online in Wiley Online Library (wileyonlinelibrary.com). DOI 10.1002/eej.21032