bluuebunny/crossref_metadata_2025_split huggingface dataset:
Analysis of Enhanced Wound Closure Potential of ADSC-Derived Secretome Compared to Aquacel Extra in Diabetic Rats
Authors: Bajuri Mohd Yazid , Rashidbenam Zahra , Mahidin Mohd Yusof , Law Jia Xian , Tan Geok Chin , Abdul Rani Rizal , Mohd Nor Fatimah , Imran Farrah Hani , Ng Min Hwei , Shafien Zikril Iman 
Published: June 2024

Background:
Diabetes Mellitus (DM) can lead to serious complications, such as Diabetic
Foot Ulcers (DFUs). Currently, Aquacel Extra is one of the standard therapies for DFUs, but
its efficacy has some limitations that may be overcome by alternative treatments, such as the secretome
derived from Adipose-Derived Stem Cells (ADSCs). ADSC secretome has shown promising
results in promoting wound healing by enhancing cell proliferation, collagen synthesis, and migration
of fibroblasts.

Aims:
This study aims to compare the effect of the adipose-derived stem cell (ADSC) secretome
to Aquacel Extra, a hydrofiber dressing containing gel-forming agents, on wound healing in a diabetic
rat model. Aquacel Extra has sodium carboxymethylcellulose fibers, which contribute to its
unique properties.

Objective:
The objective of this study is to compare the wound healing outcome of ADSC secretome
and Aquacel Extra in streptozotocin-induced diabetic rats.

Methods:
Sprague Dawley rats received a single intravenous administration of streptozotocin to
induce diabetes mellitus (DM). A full-thickness excisional circular wound was created at the dorsum
aspect of the rats two weeks after diabetic induction. Rats were randomly divided into two
groups: the Aquacel Extra group, which received the hydrofiber dressing Aquacel Extra containing
gel-forming agents, and the secretome group, which received the ADSC secretome on days 0,
3, and 7. The gross examination was performed on days 0, 3, 7, and 14. On day 14, the rats were
euthanized, and full-thickness skin biopsies of the wounds were taken for histological and immunohistochemical
analysis.

Results:
The secretome group demonstrated accelerated cutaneous wound healing compared to
the Aquacel Extra group, as indicated by faster wound closure (p < 0.05). Hematoxylin and eosin
staining revealed a thicker epidermal layer in the secretome group than in the Aquacel Extra
group (p < 0.05). The mean histological score of the secretome group was higher at 10 ± 1.73 compared
to the score of 8.33 ± 1.52 in the Aquacel Extra group, indicating a more mature tissue architecture.
Immunohistochemical analysis showed lower expression of α-smooth muscle actin (α-sma)
in the secretome group than in the Aquacel Extra group, which correlated with reduced collagen
secretion and deposition in the secretome group, as indicated by Masson’s trichrome staining.

Conclusion:
The ADSC secretome accelerated the healing of diabetic wounds compared to Aquacel
Extra. However, as this study is preliminary, future studies should be conducted similar to this
study with a larger sample and wound size. In addition, the optimal dosage of ADSC secretome
and the components of the secretome that promoted wound healing should be determined to fully
elucidate the clinical potential of ADSC secretome.
Modulating Proliferation, Migration and Differentiation of Mesenchymal
Stem Cells Using Interleukins
Authors: Srinivasan Sankaranarayanan , Ghone Nalinkanth V. 
Published: June 2024

Abstract::
Mesenchymal Stem Cells (MSCs) are multipotent stem cells that are obtained from
various tissue sources such as bone marrow, adipose tissues, umbilical cords, dental pulps, and peripheral
blood has high regenerative potential, migratory abilities, and immunosuppressive properties.
These properties make them attractive candidates for tissue engineering, immunosuppressive
therapies, and in vivo drug deliveries. MSCs, because of their high propensity to home in an injured
tissue microenvironment, are exposed to various cytokines. These cytokines modulate the activity
of MSCs to help in the regeneration of injured tissue. Interleukins are one such cytokine that
is present in injured tissue microenvironment and plays significant roles in the activation, differentiation,
proliferation, maturation, migration, and adhesion of not only immune cells but also
MSCs. Interleukins, through both autocrine and paracrine signaling mechanisms, modulate the
functioning of MSCs. This article reviews how interleukins influence MSCs by discussing their
signaling pathways, their effect on differentiation and other biological effects. A comprehensive
understanding of the influence of interleukins on MSCs may provide insights to manipulate improving
the therapeutic potential of MSCs or reducing potential risks such as undesirable immune
response and tumor formation.
Comparison of Factors Affecting the Immune Response to Hepatitis B Vaccination in Patients with Stage 5 Chronic Kidney Disease-haemodialysis and Predialysis
Authors: Light Casey , Heslop Karen , Kulkarni Hemant 
Published: June 2024

Aim
To evaluate the factors that affect the immune response to Hepatitis B vaccination in the Stage 5 chronic kidney disease population (Haemodialysis and Predialysis).

Methods
Eligible Stage 5 chronic kidney disease patients on haemodialysis (Cohort A: N= 39) and Predialysis (Cohort B: N=56) in an outer metropolitan renal service in Western Australia with no prior Hepatitis B infection or vaccination between Jan 2015 to Dec 2021 were involved in this retrospective cohort study.
Serological response to Hepatitis B vaccination (H-B-VAX II 40 mcg intramuscularly at 0, 1 and 6 months) was evaluated six-eight weeks post-vaccination. Factors such as age, gender, diabetes mellites, cardiovascular disease, hypertension, chronic obstructive airway disease, serum albumin, and erythropoietin stimulating agent dependence were studied for their influence on immune responses in these cohorts.

Results
There were 95 eligible respondents in the study. Cohort B (Predialysis) showed a significantly higher response than Cohort A (Haemodialysis) (66.1% vs 53.8%) (p=0.003). Different factors affecting the vaccine response were identified in the two cohorts. Serum albumin <35g/L was associated with negative response in 61.1% (p =0.0023)Cohort A HD patients. In the Predialysis Cohort B, 84.2%(p=0.026) were male gender, 63.2%(p=0.028) with the presence of cardiovascular disease, and 57.9%(p=0.001) who were Erythropoietin dependent showed a negative response to the vaccine.

Conclusion
This study showed that the Hepatitis B vaccine response was lower in HD patients than in Predialysis patients with stage 5 chronic kidney disease. Clinical factors of serum albumin, cardiovascular disease, and patient factors of gender and erythropoietin dependence were identified as factors that affected vaccine response in these two cohorts. We postulate these factors to be considered in the hepatitis B vaccination management to enhance immunological response strategies and extend to earlier stages of chronic kidney failure.
THE FEASIBILITY OF FUSING SATELLITE IMAGERIES FOR HIGH-FREQUENCY SEA LEVEL MONITORING
Authors: Putri Andriani , Nazhifah Sri Azizah , Ridho Abdurrahman , Maghfirah Hayatun , Mutia Cut , Niani Cukri Rahmi , Sanusi Sanusi 
Published: June 2024

Enhancing the capacity to monitor swift environmental shifts at finer scales requires satellite image that offers high spatial and temporal resolution. However, no individual satellite can offer images meeting both criteria simultaneously. To tackle this challenge, spatial temporal fusion algorithms have been developed to derive fine-scale and time-series images. Conversely, effective monitoring of water levels is crucial for preventing natural disaster, such as flood and tsunami mitigation. Yet, monitoring these natural changes regularly poses challenges for remote sensing satellites, given their limitations in either spatial or temporal resolution. For instance, the spatial resolution of 30 meters of Landsat 8 provides imagery with a but lacks the temporal resolution needed to capture dynamic events. On the contrary, the Himawari 8 has the capability to monitor the entire hemisphere every 10 minutes. However, its inadequate resolution affects the precision of sea water change mapping. This research seeks to utilize Landsat OLI and Himawari-8 images jointly for tracking sea level variation patterns. Our approach involves calculating a water index from both Landsat and Himawari images, then using an image fusion algorithm to merge these indices. Next, we identify water coverage by applying a specific threshold on the water index. The comparison of water percentages with reference water height observations has delivered encouraging outcomes.
Karakterisasi sifat mekanis paduan aluminium dari daur ulang velg untuk produk truck skateboard melalui metode investment casting
Authors: Slamet Sugeng , Kurniawan Iwan Agus , Wibowo Rianto 
Published: June 2024

Skateboarding adalah olahraga yang menggunakan papan berroda yang berjalan lurus kedepan dengan melewati berbagai rintangan. Truck merupakan salah satu komponen penting berguna sebagai penyangga skateboard terpasang di bawah board. Fabrikasi truck banyak dikerjakan dengan proses permesinan dengan detail kompleksitas dan kepresisian tinggi. Hal ini menjadi kesulitan yang dirasakan pada industri manufaktur. Penelitian ini bertujuan untuk mengembangkan teknik pengecoran logam dengan metode investment casting menggunakan paduan aluminium. Material yang digunakan paduan Aluminium dari proses daur ulang velg motor. Fabrikasi dilakukan melalui metode invesment casting dengan membuat pola menggunakan limbah lilin industri batik. Proses pengecoran dilakukan dengan memperhatikan temperatur tuang sesuai komposisi paduan. Pengujiaan mekanis dilakukan dengan uji kekuatan tarik (ASTM E8M ) dan kekerasan ( HRC). Karakterisasi terhadap paduan Aluminium daur ulang velg motor menunjukkan komposisi 93,8%Al dan 4,4%Si. Sifat mekanis terhadap nilai kekuatan tarik sebesar 121,89 MPa, modulus elastisitas 721,93 MPa dan nilai kekerasan 63,33 HRC. Metode investment casting mampu diterapkan untuk memproduksi truck skateboard dengan detail komplek dan kepresisian.
Analisis Sistem Pendingin dengan Penambahan Pipa Kapiler menggunakan Refrigeran R32
Authors: Gaelagoy Bastian M. , Aryanto Ishak , Dayera Disabella 
Published: June 2024

Sistem pendingin membutuhkan refrigeran sebagai media pendingin yang berfungsi untuk menyerap suhu rendah dan melepaskan pada suhu tinggi. Dalam sistem pendingin, di harapkan untuk meningkatkan kinerja COP pada mesin pendingin AC Spilit dengan penambahan pipa kapiler. Tabung pipa kapiler yang digunakan untuk aliran refrigeran terbuat dari tembaga. Tujuan Penelitian ini untuk mengetahui modifikasi penambahan pipa kapiler pada sistem pending AC dan mengetahui kinerja COP siklus refrigerasi yang baik di tentukan oleh nilai COP, semakin baik peringkat COP yang mengukur seberapa baik kinerja di dalam unit AC. Perbandingan panjang pipa kapiler terhadap peningkatan kinerja COP meningkat dan menurun pada T1 T2, dan T3. Panjang pipa kapiler T1 = 85 cm memiliki nilai COP tertinggi yaitu 0,492 diikuti oleh T2 = 95 cm yaitu memiliki nilai COP 0,408 dan T3 = 105 cm yaitu memiliki nilai COP 0,376. Dari penambahan panjang pipa kapiler dapat berpengaruh pada kinerja sistem refrigerasi, di mana dengan melakukan penambahan panjang pipa kapiler terdapat penurunan pada nilai COP (Coeffisien Of Performance).
Uji Eksperimental Minyak Jelantah sebagai Bahan Bakar Ramah Lingkungan
Authors: Nugroho Arif Setyo , Rahayu Aris Teguh , Cahyo Muhammad Nur 
Published: June 2024

Penelitian ini bertujuan untuk mempelajari pemanfaatan minyak jelantah menjadi bahan bakar diesel yang lebih ramah lingkungan. Pengolahan minyak jelantah agar bisa menjadi bahan bakar diesel dengan cara tranverifikasi. Minyak jelantah dipanaskan sampai dengan temperatur 50oC dan ditambahkan KOH dan methanol sebagai katalis. Dari hasil pengujian menggunakan bahan bakar minyak jelantah termodifikasi terbukti lebih irit, lama mesin menyala selama 7.1 menit dibandingkan dengan minyak solar yang hanya bisa menyala selama 6.3 menit. Gas buang CO juga lebih rendah menggunakan bahan bakar minyak jelantah yang termodifikasi sebesar 0,05% dibandingkan dengan minyak solar yang menghasilkan gas buang CO sebesar 1,27 %. Gas buang CO2 menggunakan bahan bakar minyak jelantah termodifikasi menghasilkan gas buang CO2 lebih besar yaitu 19 % dibandingkan bahan bakar solar yang menghasilkan CO2 sebesar 17%, walaupun hasil gas buang CO2 lebih tinggi , minyak jelantah yang telah termodifikasi lebih ramah lingkungan dibandingkan dengan bahan bakar solar.
Clementina XXI y el supercómputo en Argentina
Authors: Carnota Raul 
Published: June 2024

Recientemente la Argentina ingresó en el ranking TOP500 de los países que cuentan con las supercomputadoras más potentes del planeta, con la instalación y puesta en marcha de la llamada Clementina XXI. Instalada en el Data Center del Servicio Meteorológico Nacional, se convertirá en la máquina más importante de uso público y abierto de toda Sudamérica. En este artículo se describen las principales características de este equipamiento y el contexto en que se realizó su adquisición. Se presenta, además, un breve recorrido histórico del desarrollo de la computación académica en Argentina y de las capacidades y experiencia adquiridas en computación de alto desempeño. Finalmente se discuten algunos de los desafíos que se presentan en el contexto actual del país.
PENGARUH KEMAMPUAN MENGGUNAKAN F-LEARN TERHADAP MOTIVASI BELAJAR MAHASISWA
Authors: Sailana Jessica Agustin , Soesilo Tritjahjo Danny , Irawan Sapto 
Published: June 2024

Penelitian ini bertujuan untuk mengetahui signifikansi pengaruh kemampuan menggunakan F-learn terhadap motivasi belajar mahasiswa. Penelitian ini menggunakan metode kausal komparatif. Pengumpulan data menggunakan angket, digunakan dengan beberapa indikator yang berhubungan langsung dengan kedua variable. Hasil menunjukkan adanya pengaruh kemampuan menggunakan F-learn terhadap motifasi belajar partisipan yaitu mahasiswa BK UKSW Angkatan 2019 dengan nilai koefisien korelasi sebesar 0.545. Nilai ini berarti memiliki hubungan yang tinggi. Selanjutnya dilakukan analisis regresi untuk melihat pengaruh antara kemampuan menggunakan F-learn terhadap motivasi belajar mahasiswa dan di dapatkan koefisien regresi (x) sebesar 1,110. Nilai ini berarti bahwa setiap penambahan 1% nilai kemampuan menggunakan F-learn maka nilai motivasi belajar mahasiswa bertambah 1,110. Kemudian diperoleh nilai Sig. 0,000, karena sig. 0,001 < 0.050, maka variabel kemampuan menggunakan F-learn berpengaruh secara signifikan terhadap variabel motivasi belajar. Nilai RSquare sebesar 0,297 yang artinya besar sumbangan variabel Kemampuan Menggunakan F-learn terhadap variabel Motivasi Belajar sebesar 29,7 %, dan sisanya (70,3%) berasal dari variabel lain.
PENERAPAN MODEL PEMBELAJARAN PROJECT BASED LEARNING PADA MATA PELAJARAN PPKn UNTUK MENINGKATKAN HASIL BELAJAR PESERTA DIDIK KELAS VII A SMP NEGERI 16 PONTIANAK
Authors: Eja Merja Erlanda 
Published: June 2024

Tujuan penelitian ini adalah untuk meningkatkan hasil belajar peserta didik dengan memanfaatkan model Pembelajaran Project Based Learning pada mata pelajaran PPKn. Penelitian ini merupakan Penelitian Tindakan Kelas (PTK) dengan metode deskriptif. Subyek pada penelitian ini merupakan peserta didik di kelas VII A SMP Negeri 16 Pontianak yang terdiri dari 34 peserta didik. Teknik pengumpulan data menggunakan observasi, posstest, dan dokumentasi. Alat pengumpulan data meliputi lembar observasi, posttest, dan dokumentasi. Analisis hasil penelitian dilakukan dengan perhitungan nilai rata-rata dan persentase hasil. Penelitian ini dilakukan pada dua siklus. Dari setiap siklus dilaksanakan dua kali pertemuan dan setiap kali pertemuan terdiri dari tiga tahap: perencanaan (plan), pelaksanaan (do), serta refleksi (see). Hasil siklus I terhadap aktivitas guru sebesar 71%, sedangkan pada siklus II meningkat sebesar 88%. Aktivitas peserta didik juga mengalami peningkatan dari siklus I 69% menjadi 84% pada siklus II. Hasil belajar peserta didik setelah penggunaan model Project-Based Learning juga mengalami peningkatan. Hal ini dapat dilihat dari peningkatan hasil belajar pada siklus I ke siklus II, dengan peningkatan persentase ketuntasan sebesar 11,76%. Rata-rata hasil belajar dari posttest pada siklus I sebesar 81,5, dengan ketuntasan sebanyak 27 peserta didik dengan persentase 79,42%. Pada pada siklus II, rata-rata hasil belajar dari posttest sebesar 83 dengan ketuntasan sebanyak 31 peserta didik dengan persentase 91,18%. Berdasarkan hasil dari penelitian ini, dapat disimpulkan bahwa penerapan model pembelajaran Project-Based Learning pada mata pelajaran PPKn dapat meningkatkan hasil belajar peserta didik kelas VII A di SMP Negeri 16 Pontianak.
Kata Kunci : Penerapan, Project Based Learning, Hasil Belajar
Perception of Natural Cosmetics Among Central European Consumers
Authors: Hinčica Vít , Řezanková Hana , Macias Klaudia , Schulzová Marie 
Published: June 2024

Abstract
This paper aims to analyse consumers’ perceptions and attitudes towards natural cosmetic products from three Central European countries. In this study, we employed quantitative surveys on samples of 230 Czech, 175 Slovak, and 325 Polish respondents. Based on the obtained data, we investigate whether and how the respondents’ country impacts how they formulate their statements regarding the features of natural cosmetics. For each country separately, we study the dependencies of respondents’ opinions and statements on their sociodemographic profile. The results of the research show statistically significant differences in the respondents’ answers to all substantive questions depending on their country of origin. Four findings are worth highlighting: first, respondents from all three countries prefer natural cosmetics over conventional ones mainly for health and environmental reasons. Second, the frequency of buying natural cosmetics is influenced by some sociodemographic factors, although this varies in all three countries. Third, respondents who buy natural cosmetics more often are also more likely to indicate them as products of higher quality than conventional cosmetics. Lastly, the declared composition of the product is the prevailing decision criterion for consumers when selecting natural cosmetic products.
A Pilot Study in Sensor Instrumented Training (SIT) - Ground Contact Time for Monitoring Fatigue and Curve Running Technique
Authors: Blauberger P. , Fukushima T. , Russomanno T. G. , Lames M. 
Published: June 2024

Abstract
This study examines the possibilities of sensor-instrumented training (SIT) in mid-distance running training sessions. Within this framework, variations of ground contact time (GCT) between straight and curved running, as well as GCT as a fatigue indicator, are explored. Seven experienced runners, with two elite female athletes, participated in two training protocols: 15 sets of 400 m with 1-minute rest and five sets of 300 m with 3-minute rest. GCT was calculated using two inertial measurement units (IMU) attached to the athletes’ feet. The running speed of all athletes was measured with wearable GPS devices. GCT showed variations between inner and outer feet, notably during curve running (300m: 2.56%; 400m: 2.35%). However, for the 300m runs, statistically insignificant GCT differences were more pronounced in straight runs (3.54%) than in curve runs (2.56%), contrasting with the typical assumption of higher differences in curve running. A fatigue-indicating pattern is visible in GCT, as well as speed curves. Other data of this study are consistent with prior research that has observed differences between the inner and outer foot during curve running, while our understanding of the development throughout the training session is enhanced. Using SIT can be a valuable tool for refining curve running technique. By incorporating novel sensing technology, the possibilities enhance our understanding of running kinematics and offer an excellent application of SIT in sports.
Development of treated coarse recycled aggregate-based sustainable fibrous high-strength concrete with fine recycled aggregates
Authors: Dhaheer M.S. Abo , Nahhab Ali H. , Nasr Mohammed Salah 
Published: June 2024

Abstract
This research aims to develop sustainable high-strength concrete (SHSC) by replacing 100% fine and/or coarse aggregates with fine recycled aggregate (RA) and/or coarse RA. Due to the high surface water absorption of coarse RA, a surface treatment method was adopted, consisting of immersing it in a cement and silica fume slurry. Moreover, to improve the performance of the produced SHSC, steel fibers were employed at a relatively low volume fraction (0.5%). Eleven blends were cast and tested in this experimental study. A control SHSC mix (without RA) and ten other mixtures, including fine natural and RA, treated and untreated coarse RA, with and without steel fibers, were prepared. Compressive, splitting, and flexural strengths, water absorption, density, and ultrasonic pulse velocity (UPV) of the resulting SHSC were conducted. The results indicated that the use of RA in SHSC resulted in an average drop of 25% in its mechanical properties and an increase of about 30% in water absorption. However, using treated RA compensated the compressive and tensile strength reductions in SHSC by 9% and 7%, respectively, compared to mixes containing untreated RA. On the other hand, adding fibers helped improve compressive, flexural, and splitting tensile strengths by about 8%, 23%, and 31%, respectively, compared to the corresponding control mix. Consequently, the results showed that it is possible to produce durable SHSC made from 100% RA and 0.5% steel fibers with a reduced density and improved mechanical performance to a comparable level or even superior to high-strength concrete (HSC) with only natural aggregates (NAs).
Atrial standstill in a young patient treated with left bundle branch area pacing
Authors: Ecaterina Cicala , Dumitrel Luca Cezar , Catalin Pestrea 
Published: June 2024

Abstract
Atrial standstill is a rare arrhythmogenic condition characterized by the absence of electrical and mechanical activity in the atria. The therapeutic options for these patients described in the current literature, in which no reversible cause is detected, are permanent cardiac pacing, anticoagulant, and heart failure treatment when the latter exists. We present a case of a young male with no personal or family history of cardiovascular disease, diagnosed with atrial standstill after multiple syncopal episodes, in whom, because of the high expected ventricular pacing percentage, we opted for conduction system pacing with left bundle branch area pacing.
PELABELAN L(2, 1) PADA GRAF C_m âŠµ_e C_n DAN S_m âŠµ_o C_n
Authors: Lamapaha Elisabet , Haning Farly Oktriany , Putra Ganesha Lapenangga 
Published: June 2024

Diberikan $G$ suatu graf. Pelabelan $L(2,1)$ pada suatu graf $G$ merupakan suatu pemetaan $f: V(G)\rightarrow \mathbb{Z}^+\cup\{0\}$ sehingga untuk setiap $u,v\in V(G)$ dengan $d(u,v)=1$ atau $d(u,v)=2$Â memenuhi syarat selisih label kedua titik setidaknya $3-d(u,v)$. Jika $k$ merupakan bilangan bulat terbesar yang digunakan, maka pelabelan $L(2,1)$ biasa ditulis dengan pelabelan $k$-$L(2,1)$. Selanjutnya, $\lambda_{2,1}(G)$ merupakan minimum nilai $k$ sehingga terdapat pelabelan $k$-$L(2,1)$ pada $G$. Pada penelitian ini, diberikan nilai $\lambda_{2,1}$ pada graf $C_m\unrhd_e C_n$ dan graf $S_m\unrhd_o C_n$.