bluuebunny/crossref_metadata_2025_split huggingface dataset:
Statistical analysis of effective crack properties by microstructure reconstruction and phase-field modeling
Authors: Seibert Paul , Hirsch Franz , Kluge Melvin , Kalina Martha , Kalina Karl , Kästner Markus 
Published: April 2024

AbstractUnderstanding the relation between the microstructure and the material’s effective behavior is an important aspect in inverse computational materials engineering. Especially in the context of localized, inelastic phenomena like plasticity and crack growth, the microstructure morphology plays a crucial role. Due to the stochastic nature of heterogeneous media, a statistical analysis over multiple simulations is necessary, since even with the same material, the simulated crack paths and effective crack lengths are highly dependent on the specific locations of microstructural features. A relevant factor that limits this type of investigation is the high cost of real microstructure data. This work presents a digital workflow for exploring the fracture properties of materials. Therein, the required statistical analyses are facilitated by an algorithm that reconstructs multiple realization of a material structure given a single example. The reconstructed structures are discretized with a regular non-conforming mesh with a diffuse interface and crack representation. Crack phase-field simulations are conducted in order to analyze the effective response. An in-depth introduction to the required methods is given together with a statistical evaluation of the conducted numerical experiments. It is concluded that the statistical variation of the effective material behavior overshadows morphological trends in the presented case. This confirms the relevance and utility of complementing simulation-based workflows with microstructure reconstruction and statistical analyses.
Noni enhances the anticancer activity of cyclophosphamide and suppresses myelotoxicity and hepatotoxicity in tumor-bearing mice
Authors: Ali Mohammad , Manjula S. N. , Mohiuddin Ishfaq , Mruthunjaya K. , Shakeel Faiyaz , Mir Suhail Ahmad , Wani Shahid Ud Din 
Published: April 2024

Abstract
Background and aim
Morinda citrifolia fruit juice (noni) is an herbal remedy documented to have antioxidant properties. It has been suggested that prevention of carcinogen-DNA adduct formation and the antioxidant activity of NJ may contribute to the cancer preventive effect. In the present study, the antitumor activity of noni was investigated in the presence of cyclophosphamide (CYL) in vitro and in vivo.

Methods
In vitro breast cancer cells (MDA-MB-468) were used to measure the percentage of inhibition and the IC50. The in vivo antitumor activity of noni was studied by monitoring the mean survival time (MST), percentage increase in life span (%ILS), viable and non-viable cell count, tumor volume, body weight, and hematological and serum biochemical parameters in mice. Treatment with noni and CYL exhibited dose- and time-dependent cytotoxicity toward breast cancer cells.

Results
Individual treatment of noni and CYL exhibited dose- and time-dependent cytotoxicity on breast cancer cell lines, while in combination therapy of noni and CYL, noni enhances cytotoxic effect of CYL at 48 h than that at 24 h. Similar result was found in in vivo studies, the results of which revealed that alone treatment of CYL and noni suppressed tumor growth. However, combination treatment with CYL and noni presented better tumor inhibition than that of alone treatment of CYL and noni. On the contrary, CYL alone drastically attenuated hematological parameters, i.e., RBC, WBC, and Hb compared to normal and control groups, and this change was reversed and normalized by noni when given as combination therapy with CYL. Moreover, the levels of serum biochemical markers, i.e., AST, ALP, and ALT, were significantly increased in the control and CYL-treated groups than those in the normal group. In the combination treatment of noni and CYL, the above biochemical marker levels significantly decreased compared to CYL alone-treated group.

Conclusions
The present study suggested that CYL treatment can cause serious myelotoxicity and hepatic injury in cancer patients. In conclusion, the combined use of noni with CYL potentially enhances the antitumor activity of CYL and suppresses myelotoxicity and hepatotoxicity induced by CYL in tumor-bearing mice.
Anti-Anisakis antibodies in colon cancer patients and their relationship with γδ T-cells
Authors: Andreu-Ballester Juan C. , Cuéllar Carmen , Colmena-Zaragoza Javier , Galindo-Regal Lorena , Hurtado-Marcos Carolina , González-Fernández Juan , Balciscueta Zutoia , García-Ballesteros Carlos , López-Chuliá Francisca , Jiménez Ana I. , Llombart-Cussac Antonio 
Published: April 2024

AbstractMany pathogens are related to carcinogenesis. Chronic inflammation, as a result of persistent infection, leads to DNA damage, higher expression of oncogenes, decreased apoptosis and immunosuppression, which are some of the reasons for cancer induction. Among parasites, Schistosoma, Opistorchis and Clonorchis are recognised as infectious agents which contribute to cancer. A relationship between Anisakis and cancer was hypothesised because cellular responses to Anisakis products could result in inflammation and DNA damage. Previous research has shown a decrease in CD8+ γδ T-cells and an increase in αβ and γδ T-cell apoptosis in colon cancer (CC) samples. Ninety-two CC patients and 60 healthy subjects were recruited. γδ and αβ T-cells were analysed, and their apoptosis was evaluated. Anti-Anisakis antibodies were tested in sera from CC patients and controls. Anti-Anisakis IgG, IgM, IgA and IgE antibodies were significantly higher in CC patients. A significant increase in anti-Anisakis IgA levels was observed in patients with angiolymphatic invasion. The number of all γδ T-cells, as well as CD3+ CD4+ αβ T-cells, was significantly lower in CC patients. The apoptosis of all T-cells was significantly increased in patients with CC. We observed a significantly higher percentage of anti-Anisakis IgE positive patients having a deficit of CD3+ γδ T-cells. Our results suggest a relationship between Anisakis and CC.
Clinical characteristics and outcomes of immune-complex membranoproliferative glomerulonephritis and C3 glomerulopathy in Japanese children
Authors: Ueda Chika , Horinouchi Tomoko , Inoki Yuta , Ichikawa Yuta , Tanaka Yu , Kitakado Hideaki , Kondo Atsushi , Sakakibara Nana , Nagano China , Yamamura Tomohiko , Fujimura Junya , Kamiyoshi Naohiro , Ishimori Shingo , Ninchoji Takeshi , Kaito Hiroshi , Shima Yuko , Iijima Kazumoto , Nozu Kandai , Yoshikawa Norishige 
Published: April 2024

Abstract
Background
Membranoproliferative glomerulonephritis (MPGN) can be divided into immune-complex MPGN (IC-MPGN) and C3 glomerulopathy (C3G), which includes dense deposit disease (DDD) and C3 glomerulonephritis (C3GN). These conditions result from abnormalities in different complement pathways and may lead to different prognoses. However, there are limited studies describing the respective clinical courses.

Methods
In this study, Japanese pediatric patients diagnosed with MPGN based on kidney biopsies conducted between February 2002 and December 2022 were reclassified as having IC-MPGN or C3G (DDD or C3GN). We retrospectively analyzed the clinical characteristics and outcomes of these patients.

Results
Out of 25 patients with MPGN, three (12.0%) were diagnosed with DDD, 20 (80.0%) with C3GN, and two (8.0%) with IC-MPGN. There were 13 (65.0%) patients and one (33.3%) patient in remission after treatment for C3GN and DDD, respectively, and no patients with IC-MPGN achieved remission. The median follow-up period was 5.3 (2.5–8.9) years, and none of the patients in either group progressed to an estimated glomerular filtration rate < 15 ml/min/1.73 m2. Patients with C3GN presenting mild to moderate proteinuria (n = 8) received a renin-angiotensin system inhibitor (RAS-I) alone, and these patients exhibited a significant decrease in the urinary protein creatinine ratio and a notable increase in serum C3 levels at the last follow-up.

Conclusions
Most patients with MPGN were diagnosed with C3GN. The remission rate for C3GN was high, and no patients developed kidney failure during the approximately 5-year follow-up. Additionally, patients with C3GN with mild to moderate proteinuria had good outcomes with RAS-I alone, but continued vigilance is necessary to determine long-term prognosis.

Graphical abstract
Vibration analysis and control of aircraft landing systems using proposed neural controllers
Authors: Yıldırım Şahin , Durmuşoğlu Aslı 
Published: April 2024

AbstractNowadays, landing gears used in aircraft are the basic systems that carry the weight of aircraft systems and provide them to move on the ground. During the landing of aircraft, big and sudden vibrations occur as soon as the wheels come into contact with the runway. This situation negatively affects human safety, comfort and also the life of the landing gear system. Therefore, it is important to keep this vibration at permissible levels. This paper presents an improved vibration control method that controls the amplitudes of vibrations of landing systems. This paper presents proposed vibration control method that controls the angular position variables of the landing gear mechanism to control the vibrations occurring during landing. For different runway conditions and 200 km/h landing speed, the angular joint variables of the landing gear mechanism links are controlled using standard controller and a proposed neural controller structure. The simulation results are shown that the proposed neural controllers have better performance at vibration control of landing systems during landing.
Sphagnoid spores as tracers of environmental and climatic changes in peatland habitats of the early Eocene
Authors: Riegel Walter , Lenz Olaf K. , Wilde Volker 
Published: April 2024

AbstractPeat mosses have been an important part of the lignite forming vegetation in the early Eocene of the Helmstedt Lignite Mining District. Three genera of Sphagnum-type spores can be distinguished: Tripunctisporis, Distancoraesporis and Sphagnumsporites. The distribution of these sphagnoid spores is traced through seven lignite seams including most of the known hyperthermal events from the PETM to the EECO. In general, Sphagnum-type spores increase in importance from base to top in each seam as a result of acidification and nutrient depletion during peat accumulation. The proportion of Tripunctisporis increases from Main Seam to Seam 6. The lower three seams are characterized by assemblages typical for coastal plain swamp forests including tree stumps and charcoal in distinct layers and lenses. The upper seams, in which Tripunctisporis is dominant and woody material is rare, are thin-bedded with charcoal in numerous thin drapes on bedding planes. The palynomorph assemblages here indicate a low growing mainly herbaceous vegetation typical of ombrogenous bogs. The change from topogenous swamp forests to open ombrogenous bogs takes place along with the hyperthermals of the early Eocene from the PETM to the EECO. The change from a swamp forest to a shrub forest in the middle of the Main Seam coincides with the isotope excursion of the PETM. Similar changes in other seams independent of thermal events indicate that thermal events merely amplify changes in vegetation, which are primarily imposed by edaphic constraints. It is rather the rapid accumulation of hyperthermals during the EECO that exerts sufficient environmental stress to fundamentally alter the peat forming vegetation.
Graphical abstract
Altered domain-specific striatal functional connectivity in patients with Parkinson’s disease and urinary symptoms
Authors: Piramide Noemi , De Micco Rosa , Di Nardo Federica , Caiazzo Giuseppina , Siciliano Mattia , Cirillo Mario , Russo Antonio , Tedeschi Gioacchino , Esposito Fabrizio , Tessitore Alessandro 
Published: April 2024

Abstract
Background
In this study, we aimed at investigating the possible association of urinary symptoms with whole-brain MRI resting-state functional connectivity (FC) alterations from distinct striatal subregions in a large cohort of early PD patients.

Methods
Seventy-nine drug-naive PD patients (45 PD-urinary+/34 PD-urinary−) and 38 healthy controls (HCs) were consecutively enrolled. Presence/absence of urinary symptoms were assessed by means of the Nonmotor Symptom Scale - domain 7. Using an a priori connectivity-based domain-specific parcellation, we defined three ROIs (per each hemisphere) for different striatal functional subregions (sensorimotor, limbic and cognitive) from which seed-based FC voxel-wise analyses were conducted over the whole brain.

Results
Compared to PD-urinary−, PD-urinary+ patients showed increased FC between striatal regions and motor and premotor/supplementary motor areas as well as insula/anterior dorsolateral PFC. Compared to HC, PD-urinary+ patients presented decreased FC between striatal regions and parietal, insular and cingulate cortices.

Conclusions
Our findings revealed a specific pattern of striatal FC alteration in PD patients with urinary symptoms, potentially associated to altered stimuli perception and sensorimotor integration even in the early stages. These results may potentially help clinicians to design more effective and tailored rehabilitation and neuromodulation protocols for PD patients.
Oxidative Stress and FOXO-1 Relationship in Stage III Periodontitis
Authors: Gurbuz Elif Selin , Guney Zeliha , Kurgan Sivge , Balci Nur , Serdar Muhittin Abdulkadir , Gunhan Meral 
Published: April 2024

Abstract
Objectives
8-Hydroxideoxyguanosine (8-OHdG) is a marker of oxidative stress, and Forkhead Box-O1 (FOXO1) is a transcription factor and signaling integrator in cell and tissue homeostasis. This study aims to determine FOXO1 and 8-OHdG levels in serum and saliva samples of periodontitis patients and to evaluate their relationship with clinical periodontal parameters.

Materials and Methods
Twenty healthy individuals, twenty generalized Stage III Grade B periodontitis patients, and nineteen generalized Stage III Grade C periodontitis patients were included in the study. Clinical periodontal parameters (plaque index (PI), probing depth (PD), bleeding on probing (BOP), and clinical attachment level (CAL)) were recorded. Salivary and serum 8-OHdG and FOX-O1 levels were analyzed by enzyme-linked immunosorbent assay (ELISA).

Results
Clinical periodontal parameters showed a statistically significant increase in periodontitis groups compared to the control group (p < 0.05). 8-OHdG salivary levels were significantly higher in both periodontitis groups compared to the control group. The salivary FOXO1 levels were significantly lower in both periodontitis groups compared to the control group. Salivary FOXO1 level had a low-grade negative correlation with BOP and salivary 8-OHdG level.

Conclusions
While reactive oxygen species increase in periodontal inflammation, low expression of FOXO1, an important transcription factor for antioxidant enzymes, supports that this molecule plays a vital role in tissue destruction, and FOXO1 can be seen as a potential immune modulator.

Clinical relevance
The role of FOXO1 in supporting antioxidant defense may suggest that FOXO1 is a candidate target for periodontitis treatment.
The underlying neuropsychological and neural correlates of the impaired Chinese reading skills in children with attention deficit hyperactivity disorder
Authors: Wu Zhao-Min , Wang Peng , Zhong Yun-Yu , Liu Yun , Liu Xue-Chun , Wang Jiu-Ju , Cao Xiao-Lan , Liu Lu , Sun Li , Yang Li , Zang Yu-Feng , Qian Ying , Cao Qing-Jiu , Wang Yu-Feng , Yang Bin-Rang 
Published: April 2024

AbstractImpaired basic academic skills (e.g., word recognition) are common in children with Attention Deficit Hyperactivity Disorder (ADHD). The underlying neuropsychological and neural correlates of impaired Chinese reading skills in children with ADHD have not been substantially explored. Three hundred and two children with ADHD (all medication-naïve) and 105 healthy controls underwent the Chinese language skill assessment, and 175 also underwent fMRI scans (84 ADHD and 91 controls). Between-group and mediation analyses were applied to explore the interrelationships of the diagnosis of ADHD, cognitive dysfunction, and impaired reading skills. Five ADHD-related brain functional networks, including the default mode network (DMN) and the dorsal attention network (DAN), were built using predefined regions of interest. Voxel-based group-wise comparisons were performed. The ADHD group performed worse than the control group in word-level reading ability tests, with lower scores in Chinese character recognition (CR) and word chains (WS) (all P < 0.05). With full-scale IQ and sustained attention in the mediation model, the direct effect of ADHD status on the CR score became insignificant (P = 0.066). The underlying neural correlates for the orthographic knowledge (OT) and CR differed between the ADHD and the control group. The ADHD group tended to recruit more DMN regions to maintain their reading performance, while the control group seemed to utilize more DAN regions. Children with ADHD generally presented impaired word-level reading skills, which might be caused by impaired sustained attention and lower IQ. According to the brain functional results, we infer that ADHD children might utilize a different strategy to maintain their orthographic knowledge and character recognition performance.
Disclosure services and welfare gains in matching markets for indivisible assets
Authors: Kawakami Kei 
Published: April 2024

AbstractWe present a competitive matching model in which indivisible assets are reallocated among many traders. The model has three features: (i) traders are heterogeneous in their prospects as buyers, sellers, and also in their stand-alone values with endowed assets, (ii) buyers do not know true values of assets sold, (iii) sellers can disclose values of their assets by paying fees. Despite its complexity, the model admits closed-form solutions. Two main results emerge. First, if full Disclosure is facilitated by a monopolist, it captures a large fraction of the welfare gains. Second, adding the option of minimum disclosure, when combined with a cap regulation on price-dependent fees for full disclosure, significantly weakens the monopolist’s power.
Opioid use surrounding diagnosis and follow-up in patients with ankylosing spondylitis, psoriatic arthritis, and rheumatoid arthritis: Results from US claims databases
Authors: Sheahan Anna , Anjohrin Suzanne , Suruki Robert , Stark Jeffrey L. , Sloan Victor S. 
Published: April 2024

Abstract
Objective
To describe patients’ use of opioids in the year preceding and year following new diagnosis of ankylosing spondylitis (AS), psoriatic arthritis (PsA), or rheumatoid arthritis (RA), compared with patients without the/se diseases.

Methods
This study used US IBM® MarketScan® Commercial Claims and Encounters (CCAE) and Medicaid data and included three cohorts, comprised of incident cases of AS, PsA, or RA (2010–2017). Three matched comparator patients (without the incident disease) were selected for each patient within the disease cohort. Opioid use and appropriate treatment exposure (as defined by US guideline recommendations) in the 12-month baseline and follow-up periods were evaluated using descriptive analyses.

Results
Prevalence of claims for opioids was higher for disease cohorts vs. comparators in CCAE; 36.4% of patients with AS, 29.5% with PsA, and 44.4% with RA did not have any claim for guideline-appropriate therapy in follow-up. Prevalence of claims for opioids was also higher for disease cohorts vs. comparators in Medicaid; 30.6% of patients with AS, 36.6% with PsA, and 65.4% with RA did not have any claim for guideline-appropriate therapy in follow-up.

Conclusions
In patients with AS, PsA, or RA, there was high reliance on opioids at and around the time of diagnosis. Significant proportions of patients were not on appropriate treatment as defined by professional society post-diagnosis guidelines; this discordance between actual patient therapies and treatment recommendations may suggest a need for better awareness of appropriate pain management and treatment strategies in rheumatic diseases.

Key Points

• This study analysed opioid use among patients with ankylosing spondylitis (AS), psoriatic arthritis (PsA), or rheumatoid arthritis (RA), and adds to current knowledge by expanding beyond assessment of opioid use at diagnosis, to the year before and after diagnosis.• Opioid use was found to be highly prevalent in AS, PsA, and RA in the year prior to diagnosis and, interestingly, was still seen during the year after diagnosis.• Opioids are neither disease modifying, nor a targeted/recommended treatment for chronic autoimmune diseases. In addition to their association with significant economic costs, opioids are potentially hazardous and are not better than alternative treatments with superior safety profiles.• The reasons behind opioid prescribing patterns should be explored further to support movement to targeted therapies.
Predictors of atrial fibrillation after embolic stroke of undetermined source in patients with implantable loop recorders
Authors: Kreimer Fabienne , Aweimer Assem , El-Battrawy Ibrahim , Labedi Adnan , Schneider Ruth , Haghikia Arash , Mügge Andreas , Gotzmann Michael 
Published: April 2024

Abstract
Background
In patients with embolic stroke of undetermined source (ESUS), underlying subclinical atrial fibrillation (AF) is often suspected. Previous studies identifying predictors of AF have been limited in their ability to diagnose episodes of AF. Implantable loop recorders enable prolonged, continuous, and therefore more reliable detection of AF. The aim of this study was to identify clinical and ECG parameters as predictors of AF in ESUS patients with implantable loop recorders.

Methods
101 ESUS patients who received an implantable loop recorder between 2012 and 2020 were included in this study. Patients were followed up regularly on a three-monthly outpatient interval.

Results
During a mean follow-up of 647 ± 385 days, AF was detected in 26 patients (26%). Independent risk factors of AF were age ≥ 60 years (HR 2.753, CI 1.129–6.713, p = 0.026), P-wave amplitude in lead II ≤ 0.075 mV (HR 3.751, CI 1.606–8.761, p = 0.002), and P-wave duration ≥ 125 ms (HR 4.299, CI 1.844–10.021, p < 0.001). In patients without risk factors, the risk of developing AF was 16%. In the presence of one risk factor, the probability increased only slightly to 18%. With two or three risk factors, the risk of AF increased to 70%.

Conclusion
AF was detected in about one in four patients after ESUS in this study. A comprehensive evaluation involving multiple parameters and the existence of multiple risk factors yields the highest predictive accuracy for detecting AF in patients with ESUS.