bluuebunny/crossref_metadata_2025_split huggingface dataset:
Femoral Torsion: Reliability and Validity of the Trochanteric Prominence Angle Test
Authors: Maier Claudia , Zingg Patrick , Seifert Burkhardt , Sutter Reto , Dora Claudio 
Published: August 2012

Influence of femoral torsion on femoroacetabular impingement and other hip conditions is not well documented and its assessment by imaging methods during clinical work-up is not routinely performed. We studied whether physical examination could reliably measure or at least screen for gross anomalies of femoral torsion or if appropriate imaging should routinely be performed. Assessing femoral torsion of 45 volunteers using the “trochanteric prominence angle test” and magnetic resonance imaging (MRI), inter- and intra-observer reliability ranged from poor to moderate and agreement with MRI values was only fair. Considering a 5° to 10° difference of femoral torsion as clinically relevant, physical examination failed to match MRI values within ±10° in more than 50%. Arbitrarily defining thresholds for pathological femoral torsion, the “trochanteric prominence angle test” could not recognise torsions outside the >30°/<0° range and diagnosed torsions outside the >20°/<10° range with a sensitivity of 18%-75% and a specificity of 58%-98% only. Physical assessment of femoral torsion using the “trochanteric prominence angle test” does not allow reliable measurement or screening for gross anomalies. We therefore integrate an adapted MRI protocol allowing measurement of femoral torsion within our clinical work up.
Physicochemical and sensorial characteristics of four muscles from commercial crossbred pigs slaughtered at 130 kg body weight
Authors: Calvo S. , Rodríguez-Sánchez J. A. , Panea B. , Latorre M. A. 
Published: August 2012

In Spain, a sizeable proportion of pigs are slaughtered above 100 kg of body weight because are mainly intended for dry-cured ham elaboration. The chance of finding pork cuts differentiated by quality, which might be intended for fresh meat consumption, would optimize the production of heavy carcasses. The aim of this work was to evaluate the physicochemical and sensory characteristics of four muscles from heavy pigs. A total of 14 Duroc × (Landrace × Large White) gilts were slaughtered at 130 kg of body weight. From each carcass, the following muscles (two per carcass) were excised: Longissimus thoracis (LT), Psoas major (PM), Lattissimus dorsi (LD) and Serratus ventralis (SV). Several physical (color, moisture losses and resistance to cutting), chemical (intramuscular fat content and its fatty acid profile) and sensorial (attributes related to aroma, flavor, texture and acceptability) characteristics were evaluated. The LT had the highest fibrousness and the lowest water holding capacity indicators, tenderness and juiciness. The PM showed the lowest intramuscular fat and monounsaturated fatty acid contents and fibrousness, and the highest moisture, C18:2n6 and polyunsaturated fatty acid proportions. The LD had the highest yellowness and intensity of fat odor and flavor. The SV provided the highest intramuscular fat content and red color, and the lowest resistance to cutting. All muscles had similar score in global acceptability. There were several interesting physicochemical and sensory differences among the muscles studied which suggest that they might be commercialized individually as meat cuts of differentiated quality optimizing the use of heavy pig carcasses.
COVID‐19 Vaccination Before Initiating Rituximab Treatment Induces Strong Serological Response in Autoimmune Rheumatic Disease, Reducing Post‐Pandemic Concerns About the Impact of Rituximab
Authors: Ammitzbøll Christian , Thomsen Marianne Kragh , Bartels Lars Erik , Hansen Cecilie Bo , Hermansen Marie‐Louise From , Hänel Mathias , Klose‐Jensen Rasmus , Larsen Mads Lamm , Lauritsen Morgan Oliver , Mistegaard Clara Elbæk , Mikkelsen Susan , Olesen Janne Bille Mønster , Næser Esben Uggerby , Nielsen Morten Aagaard , Erikstrup Christian , Garred Peter , Hauge Ellen‐Margrethe , Troldborg Anne 
Published: June 2024

ObjectiveRituximab (RTX)‐treated patients exhibit suboptimal responses to COVID‐19 vaccines. However, existing research primarily involves patients already receiving RTX when vaccines were introduced, failing to account for the current landscape where patients are vaccinated before initiating RTX. Our objective was to compare the serological response to COVID‐19 vaccines in patients vaccinated before or after RTX initiation.MethodsWe included 254 RTX‐treated patients with autoimmune inflammatory rheumatic diseases (AIIRDs) and 113 blood donors (BDs) in a retrospective, observational cohort study. Patients were categorized based on the timing of RTX treatment relative to primary COVID‐19 vaccination. Serological vaccine responses were assessed using three immunoassays, and logistic regression analysis was used to identify predictors of serological response.ResultsPatients vaccinated before initiating RTX treatment had significantly higher seroconversion rates of SARS‐CoV‐2 immunoglobulin G (87%) and neutralizing antibodies (91%) compared with those receiving RTX before and after vaccination (n = 132) (61% and 65%, respectively). In the logistic regression analysis, a positive serological response was associated with the number of vaccines administered >9 months after the last RTX treatment. Patients receiving the highest number of vaccines with >9 months after RTX showed a response comparable to that of the BDs.ConclusionVaccinating before RTX initiation yields a robust serological response in patients with AIIRDs. Furthermore, we highlight the reversibility of antibody impairment after RTX treatment cessation, provided that adequate vaccinations occur within a minimum of 9 months after RTX. Our findings offer essential insights for clinical decision‐making regarding COVID‐19 vaccination and RTX treatment, alleviating concerns about future RTX use.image
Functionalized BP@(Zn+Ag)/EPLA Nanofibrous Scaffolds Fabricated by Cryogenic 3D Printing for Bone Tissue Engineering
Authors: Chen Shunyu , Qiu Zhoucheng , Zhao Lihua , Huang Xiaojing , Xiao Xiufeng 
Published: June 2024

AbstractThis study fabricates a functionalized scaffold by cryogenic three‐dimensional (3D) printing using an aminated poly‐L‐lactic acid (EPLA) solution containing nanosilver/zinc‐coated black phosphorus (BP@(Zn+Ag)) nanocomposites. The nanocomposites are prepared by a green method of in situ photodeposition of silver and zinc nanoparticles (AgNPs and ZnNPs) on BP nanosheets (BPNs) under visible light irradiation without any chemical reductant. Scanning electron microscope (SEM) and X‐ray energy dispersive spectrometer (EDS) confirm the uniform distribution of BP@(Zn+Ag) nanoparticles in the EPLA nanofibrous matrix. The in vitro tests show that the fabricated BP@(Zn+Ag)/EPLA nanofibrous scaffold exhibits excellent antibacterial activity (over 96%) against E. coli and S. aureus, as well as enhanced cell viability and osteogenic activity to facilitate the growth and differentiation of osteoblasts. The in vivo rat calvarial defect model also demonstrates that the BP@(Zn+Ag)/EPLA nanofibrous scaffold promotes new bone tissue formation around the implant site. Therefore, the prepared multifunctional 3D printed BP@(Zn+Ag)/EPLA nanofibrous scaffold has great potential for bone tissue engineering (BTE) applications.
Defect‐Engineered Metal–Organic Frameworks as Nanocarriers for Pharmacotherapy: Insights into Intracellular Dynamics at The Single Particle Level
Authors: Huang Ge , Dreisler Marcus Winther , Kæstel‐Hansen Jacob , Nielsen Annette Juma , Zhang Min , Hatzakis Nikos S. 
Published: June 2024

AbstractNanoscale Metal–Organic Frameworks (nanoMOFs) are widely implemented in a host of assays involving drug delivery, biosensing catalysis, and bioimaging. However, the cell pathways and cell fate remain poorly understood. Here, a new fluorescent nanoMOF integrating ATTO 655 into surface defects of colloidal UiO‐66 is synthesized, allowing to track the spatiotemporal localization of Single nanoMOF in live cells. Density functional theory reveals the stronger binding of ATTO 655 to the Zr6 cluster nodes compared with phosphate and Alendronate Sodium. Parallelized tracking of the spatiotemporal localization of thousands of nanoMOFs and analysis using machine learning platforms reveals whether nanoMOFs remain outside as well as their cellular internalization pathways. To quantitatively assess their colocalization with endo/lysosomal compartments, a colocalization proxy approach relying on the nanoMOF detection of particles in one channel to the signal in the corresponding endo/lysosomal compartments channel, considering signal versus local background intensity ratio and signal‐to‐noise ratio is developed. This strategy mitigates colocalization value inflation from high or low signal expression in endo/lysosomal compartments. The results accurately measure the nanoMOFs’ colocalization from early to late endosomes and lysosomes and emphasize the importance of understanding their intracellular dynamics based on single‐particle tracking for optimal and safe drug delivery.
Enhanced Interlayer Interaction in Top‐Layer Twisted Trilayer MoS2 with Moiré Superlattice
Authors: Liu Yalin , Zhang Tiantian , Zhou Jun , Zhu Meijie , Zhao Zihan , Zhang Weifeng , Feng Yibiao , Guo Xiaopeng , Liu Nan , Nie Jiacai , Chen Shanshan , Dou Ruifen 
Published: June 2024

AbstractMoiré superlattices, induced by an angular mismatch in layered materials provide a new index of freedom to manipulate the correlated electron states and many‐body properties of excitons. Here, trilayer MoS2 homostructures with the 3R configuration between the middle (M) and the bottom (B) layer and the top‐to‐middle (T‐M) interlayer twists ranging from 10° to 40° are fabricated via NaCl‐assisted chemical vapor deposition. The twist‐dependent interlayer interactions are systematically investigated by polarized low frequency (PLF) and high frequency (HF) Raman spectroscopy. PLF Raman results show that the energy shift in the shear mode, the breathing modes of LB31 and LB32 is respectively the much in 14°‐ and 28°‐T‐M twisted trilayer, among as‐prepared trilayer MoS2 homostructures. Moreover, the T‐M twist further affects the optical properties of the twisted MoS2 trilayer, evidenced by the photoluminescence (PL) spectroscopy. Moiré excitons are enhanced in the top‐layer twisted MoS2 trilayer with a T‐M twists of 28°, which may originate from the interlayer exciton trapped by the periodical moiré potential. The present work demonstrates that the trilayer homostructures tuned by interlayer twists can be an ideal system to tune the energy band structures and exciton properties for their potential applications in the nano‐optical electronics.
Unexplored Exciplex Formation by Dual Excitation of Donor and Acceptor Layers Optically and Electrically
Authors: Rajakaruna Tharindu P. B. , Tang Xun , Nakanotani Hajime , Adachi Chihaya 
Published: June 2024

AbstractElectron donor and acceptor interactions are the fundamentals for the emergence of optoelectronic functions in most organic devices. In particular, exciplexes, which hold the possibility to utilize dark triplets, are widely investigated in organic light‐emitting diodes. However, the relatively low radiative decay rate with a low photoluminescence quantum yield poses further advanced challenges. Traditionally, it is well recognized that exciplexes are formed through a charge transfer process, i.e., direct electron transfer, by photoexciting either a donor or an acceptor component. In this study, the focus is on a long‐range exciplex system where tris(4‐carbazoyl‐9‐ylphenyl)amine (TCTA) and 2,4,6‐tris[3‐(diphenylphosphinyl)phenyl]−1,3,5‐triazine (PO‐T2T) serve as the donor and acceptor, respectively. Moreover, 1,2‐bis(triphenylsilyl) benzene (UGH2) and bis[2‐(diphenylphosphino)phenyl]ether oxide (DPEPO), having a wide energy gap and a high triplet energy level, are employed as the double insulating layer to suppressing direct electron transfer between the donor and acceptor. The indirect through‐space exciplex formation is demonstrated by the simultaneous excitation of both donor and acceptor layers optically and electrically, providing a new route for exciplex formation.
Development of Iron‐Based Single Atom Materials for General and Efficient Synthesis of Amines
Authors: Ma Zhuang , Kuloor Chakreshwara , Kreyenschulte Carsten , Bartling Stephan , Malina Ondrej , Haumann Michael , Menezes Prashanth W. , Zbořil Radek , Beller Matthias , Jagadeesh Rajenahally V. 
Published: June 2024

AbstractEarth abundant metal‐based heterogeneous catalysts with highly active and at the same time stable isolated metal sites constitute a key factor for the advancement of sustainable and cost‐effective chemical synthesis. In particular, the development of more practical, and durable iron‐based materials is of central interest for organic synthesis, especially for the preparation of chemical products related to life science applications. Here, we report the preparation of Fe‐single atom catalysts (Fe‐SACs) entrapped in N‐doped mesoporous carbon support with unprecedented potential in the preparation of different kinds of amines, which represent privileged class of organic compounds and find increasing application in daily life. The optimal Fe‐SACs allow for the reductive amination of a broad range of aldehydes and ketones with ammonia and amines to produce diverse primary, secondary, and tertiary amines including N‐methylated products as well as drugs, agrochemicals, and other biomolecules (amino acid esters and amides) utilizing green hydrogen.
Direct Microenvironment Modulation of CO2 Electroreduction: Negatively Charged Ag Sites Going beyond Catalytic Surface Reactions
Authors: Dai Ruoyun , Sun Kaian , Shen Rongan , Fang Jinjie , Cheong Weng‐Chon , Zhuang Zewen , Zhuang Zhongbin , Zhang Chao , Chen Chen 
Published: June 2024

AbstractElectrochemical reduction of CO2 is an important way to achieve carbon neutrality, and much effort has been devoted to the design of active sites. Apart from elevating the intrinsic activity, expanding the functionality of active sites may also boost catalytic performance. Here we designed “negatively charged Ag (nc‐Ag)” active sites featuring both the intrinsic activity and the capability of regulating microenvironment, through modifying Ag nanoparticles with atomically dispersed Sn species. Different from conventional active sites (which only mediate the surface processes by bonding with the intermediates), the nc‐Ag sites could also manipulate environmental species. Therefore, the sites could not only activate CO2, but also regulate interfacial H2O and CO2, as confirmed by operando spectroscopies. The catalyst delivers a high current density with a CO faradaic efficiency of 97 %. Our work here opens up new opportunities for the design of multifunctional electrocatalytic active sites.
Auto‐Optimized Electro‐Flow Reactor Platform for the in‐situ Reduction of P(V) Oxide to P(III) and Their Application
Authors: Purwa Mandeep , Chandrakanth Gaykwad , Rana Abhilash , Mottafegh Amirreza , Kumar Sanjeev , Kim Dong‐Pyo , Singh Ajay K. 
Published: June 2024

AbstractTrivalent phosphine catalysis is mostly utilized to activate the carbon‐carbon multiple bonds to form carbanion intermediate species and is highly sensitive to certain variables. Random manual multi‐variables are critical for understanding the batch disabled regeneration of trivalent phosphine chemistry. We need the artificial intelligence‐based system which can change the variable based on previously conducted failed experiment. Herein, we report an auto‐optimized electro‐micro‐flow reactor platform for the in‐situ reduction of stable P(V) oxide to sensitive P(III) and further utilized the method for Corey‐Fuchs reaction.
Development and validation of a liquid chromatography–tandem mass spectrometry method for simultaneous quantification of eight Xiakucao Oral liquid–related compounds in rat plasma and its application in pharmacokinetic study
Authors: Jin Jingyi , Xu Xiaoqing , Wang Xinwei , Chen Biao , Miao Yingying , Chen Zhongguo , Yan Dongming , Qiu Furong 
Published: June 2024

AbstractXiakucao Oral Liquid (XKCOL) has been widely used for treating mammary gland hyperplasia and goiter in China. However, its pharmacokinetic data have been missing to date. To conduct its pharmacokinetic study, we established an LC–tandem mass spectrometry method for the simultaneous determination of eight XKCOL‐related compounds in rat plasma. Liquid–liquid extraction was used for the sampling process. Chromatographic separation was performed on a Phenomenon Luna C18 column with a mobile phase of methanol and 2 mM ammonium acetate, using gradient elution at a flow rate of 0.8 mL/min. Detection was performed in the multiple reaction monitoring mode using negative electrospray ionization (ESI−) with optimized MS parameters. Endogenous substances and carryover did not interfere in the detection of analytes. The calibration curves showed a good linear relationship within the linear ranges. The intra‐ and inter‐batch accuracy and precision were 94.8%–110.0% and ≤11.2%, respectively. There was no significant matrix effect and the recovery was reproducible. The dilution of samples did not affect the accuracy and precision. The solution and plasma samples were stable under the various test conditions. The major components of XKCOL absorbed into the blood were salvianic acid A and rosmarinic acid. They demonstrated linear kinetics over the dose range used in this study.
Revealing the material basis and mechanism for the inhibition of intestinal peristalsis by Zingiber officinale Roscoe through integrated metabolomics, serum pharmacochemistry, and network pharmacology
Authors: Xiong Lewen , Xuan Jing , Zhao Hongwei , Zhang Zhaoyu , Wang Haonan , Yan Peizheng , Zhang Yongqing , Liu Yan , Zhang Longfei 
Published: June 2024

AbstractAbnormal relaxation and contraction of intestinal smooth muscle can cause various intestinal diseases. Diarrhea is a common and important public health problem worldwide in epidemiology. Zingiber officinale Roscoe (fresh ginger) has been found to treat diarrhea, but the material basis and mechanism of action that inhibits intestinal peristalsis remain unclear. Metabolomics and serum pharmacology were used to identify differential metabolites, metabolic pathways, and pharmacodynamic substances, and were then combined with network pharmacology to explore the potential targets of ginger that inhibit intestinal peristalsis during diarrhea treatment, and the targets identified were verified using molecular docking and molecular dynamic simulation. We found that 25 active components of ginger (the six most relevant components), 35 potential key targets (three core targets), 40 differential metabolites (four key metabolites), and four major metabolic pathways were involved in the process by which ginger inhibits intestinal peristalsis during diarrhea treatment. This study reveals the complex mechanism of action and pharmacodynamic material basis of ginger in the inhibition of intestinal peristalsis, and this information helps in the development of new Chinese medicine to treat diarrhea and lays the foundation for the clinical application of ginger.
Avelumab first‐line maintenance in advanced urothelial carcinoma: Complete screening for prognostic and predictive factors using machine learning in the JAVELIN Bladder 100 phase 3 trial
Authors: Manitz Juliane , Gerhold‐Ay Aslihan , Kieslich Pascal , Shah Parantu , Mrowiec Thomas , Tyroller Karin 
Published: June 2024

AbstractBackgroundAvelumab first‐line (1 L) maintenance is a standard of care for advanced urothelial carcinoma (aUC) based on the JAVELIN Bladder 100 phase 3 trial, which showed that avelumab 1 L maintenance + best supportive care (BSC) significantly prolonged overall survival (OS) and progression‐free survival (PFS) vs BSC alone in patients who were progression free after receiving 1 L platinum‐containing chemotherapy. Here, we comprehensively screened JAVELIN Bladder 100 trial datasets to identify prognostic factors that define subpopulations of patients with longer or shorter OS irrespective of treatment, and predictive factors that select patients who could obtain a greater OS benefit from avelumab 1 L maintenance treatment.MethodsWe performed machine learning analyses to screen a large set of baseline covariates, including patient demographics, disease characteristics, laboratory values, molecular biomarkers, and patient‐reported outcomes. Covariates were identified from previously reported analyses and established prognostic and predictive markers. Variables selected from random survival forest models were processed further in univariate Cox models with treatment interaction and visually inspected using correlation analysis and Kaplan–Meier curves. Results were summarized in a multivariable Cox model.ResultsPrognostic baseline covariates associated with OS included in the final model were assignment to avelumab 1 L maintenance treatment, Eastern Cooperative Oncology Group performance status, site of metastasis, sum of longest target lesion diameters, levels of C‐reactive protein and alkaline phosphatase in blood, lymphocyte proportion in intratumoral stroma, tumor mutational burden, and tumor CD8+ T‐cell infiltration. Potential predictive factors included site of metastasis, tumor mutation burden, and tumor CD8+ T‐cell infiltration. An analysis in patients with PD‐L1+ tumors had similar findings to those in the overall population.ConclusionsMachine learning analyses of data from the JAVELIN Bladder 100 trial identified potential prognostic and predictive factors for avelumab 1 L maintenance treatment in patients with aUC, which warrant further evaluation in other clinical datasets.
Hierarchical N‐doped Carbon Nanosheets Anchored Bimetallic Oxides for Selective Hydrogenation of Phenylacetylene
Authors: Yang Shu‐Jie , Chen Min‐Jie , Liu Chao , Yao Yao , Xu Hong‐Jian , Zhao Xin‐Yu , Zhao Ze‐Lin , Li Jun‐Sheng , Chang Gang‐Gang , Yang Xiao‐Yu 
Published: June 2024

AbstractSelective hydrogenation of alkynes to alkenes using a low‐cost non‐noble metal catalyst is urgently desirable but challenging because of their over‐hydrogenation to undesired alkanes. Herein, a series of hierarchical N‐doped carbon nanosheets anchored bimetallic oxides were successfully fabricated. The resultant composite catalysts had advantages associated with not only two‐dimensionality (2D) nanosheets with highly active sites and fast mass transfer, but also bimetallic oxides that dissociate and transfer hydrogen with the assistance of the oxygen vacancies. Furthermore, the bimetallic oxides combined with the advantages of high activity of Ni and the selectivity regulation of Co. Benefiting from these advantages, the catalytic performance of CoNiO2−ZnCo2O4/NC NSs can reach nearly full conversion with 92 % selectivity at moderate reaction conditions and can keep excellent selectivity even prolonging the reaction time to 12 h, outperforming CoNiO2−ZnCo2O4/NC NPs, CoO−ZnCo2O4/NC NSs, and the commercial Lindlar catalysts, which demonstrate the huge potential for selective hydrogenation applications.