bluuebunny/crossref_metadata_2025_split huggingface dataset:
Study protocol OKRA: orientation compass for the preparing, delivering and following up on breaking bad news conversations in paediatric oncology
Authors: Krieger Theresia , Dittmer Kerstin , Reinert David , Hömberg Marc , Tepe Andrea , Hamm Isabel , Vitinius Frank 
Published: June 2024

IntroductionIn paediatric oncology, ‘breaking bad news’—BBN—like cancer diagnosis is perceived as particularly challenging. Enabling a trialogue between children with their relatives and health professionals requires profound communication skills. Lacking the skills, experience or adequate support tools might result in negative consequences for both paediatric oncologists as BBN transmitters and BBN receivers as children with cancer and their relatives.In contrast to oncology for adults, multiperspective studies that explore BBN experience and specific support needs are rare, especially in Germany. Systematically developed and practically piloted support instruments, which address the specific needs of paediatric oncology, are missing.ObjectiveTo systematically design and mature in practice an orientation compass for preparing, delivering and following up on BBN conversations in paediatric oncology—so-called Orientierungskompass zur Übermittlung schwerwiegender Nachrichten in der Kinderonkologie (OKRA).Methods and analysisOKRA is based on a QUAL-quant mixed study design, comprising two phases. Four groups will contribute (1) experts through personal experience (representatives for children receiving BBN and their parents), (2) medical care providers and representatives of national medical societies, (3) ambulant psychosocial/psychological support providers and (4) researchers. In phase 1, multiperspective knowledge is generated through a participatory group Delphi that involves in-depth interviews, focus group discussions and questionnaires. This process culminates in formulating theses for a high-quality BBN process (output phase 1). In phase 2, based on the theses, a pilot orientation compass is designed. Through iterative cycles with the participatory action research method, this instrument will be piloted in three paediatric oncological settings and consequently optimised.Ethics and disseminationOKRA was approved on 19 September 2023 by the ethics committee of the Medical Faculty of the University of Cologne (No. 23-1187). After project completion, the OKRA compass will be distributed to multidisciplinary paediatric oncology teams throughout Germany.Trial registration numberDRKS00031691.
Normal range and risk factors for deviating body temperatures during the first 24 hours in term-born infants under standardised care: an observational study
Authors: Tveiten Lars , Diep Lien My , Halvorsen Thomas , Markestad Trond 
Published: June 2024

ObjectiveBody temperature for a known ambient temperature is not known for infants born at term. We aimed to determine the normal range and the incidences of hypothermia and hyperthermia during the first 24 hours of life in healthy term-born infants nursed according to WHO recommendations.DesignProspective observational study.SettingNorwegian single centre district hospital. Infants were observed during skin-to-skin care or when dressed in cots.ParticipantsConvenience sample of 951 healthy infants born at term.MethodsDelivery room temperature was aimed at 26–30°C and rooming-in temperature at 24°C. We measured rectal and room temperatures at 2, 4, 8, 16 and 24 hours of age.Main outcome measuresPercentile curves for rectal temperature. Proportions and risk factors for hypothermia and hyperthermia.ResultsThe mean (SD) room temperature was 24.0°C (1.1), 23.8°C (1.0), 23.8°C (1.0)., 23.7°C (0.9) and 23.8°C (0.9). The median (2.5, 97.5 percentile) rectal temperature was 36.9°C (35.7–37.9), 36.8°C (35.9–37.5), 36.9°C (36.1–37.5), 37.0°C (36.4–37.7) and 37.1°C (36.5–37.7). Hypothermia (<36.5°C) occurred in 28% of the infants, 82% of incidents during the first 8 hours. Risk factors for hypothermia were low birth weight (OR 3.1 (95% CI, 2.0 to 4.6), per kg), male sex, being born at night and nursed in a cot versus skin to skin. Hyperthermia (>37.5°C) occurred in 12% and most commonly in large infants after 8 hours of life. Risk factors for hyperthermia were high birth weight (OR 2.2 (95% CI, 1.4 to 3.5), per kg), being awake, nursed skin to skin and being born through heavily stained amniotic fluid.ConclusionsTerm-born infants were at risk of hypothermia during the first hours after birth even when nursed in an assumed adequate thermal environment and at risk of hyperthermia after 8 hours of age.
Optimization of a CH<sub>3</sub>NH<sub>3</sub>SnI<sub>3</sub> based lead-free organic perovskite solar cell using SCAPS-1D simulator
Authors: Rana Md. Sohel , Abdur Razzak Md. 
Published: June 2024

In this study, a CH3NH3SnI3-based perovskite PV cell with the structure (FTO/TiO2/CH3NH3SnI3/Cu2O) was made and optimized by changing the layer thickness, defect density, and doping profile using the solar cell capacitance simulator (SCAPS) 1D simulator. To better understand how the device interface affects carrier dynamics, a synergic optimization of the device is done by altering the electron-transport layer (ETL) and hole-transport layer (HTL) materials. The light glows through the window layer of Sn2O: F, which serves as the transparent conducting oxide layer in our suggested cell construction and then travels over TiO2 as an n-type ETL. Due to its unique features, the p-type perovskite (CH3NH3SnI3) is chosen as the primary absorber layer. Lastly, Cu2O is added as an HTL before the back contact because it has a higher hole conductivity and the proper offsets for spreading the valance and conduction bands. Additionally, Cu2O-based devices outperform frequently utilized spiro-OMeTAD-based devices in terms of efficiency. According to the findings of these simulations, the optimized structure has a power conversion efficiency (PCE) of 41%, an open-circuit voltage of 1.32 V, a short-circuit current density of 34.31 mA/cm2 and a fill factor (FF) of 90.5%. Additionally, the optimized structure has a short-circuit current density of 34.31 mA/cm2.
Optimizing EV charging stations: a simulation-based approach to performance and grid integration
Authors: Sanchez Diaz William Fabián , Vargas Jonatan Tolosa , Martinez Fredy 
Published: June 2024

This study addresses the optimization of electric vehicle (EV) charging stations, focusing on enhancing performance and grid integration through a comprehensive simulation approach. By employing advanced simulation tools in Simulink® and MATLAB®, alongside electrical installation planning with SIMARIS®, we meticulously analyze the charging process, infrastructure requirements, and their implications on the power grid. Our results demonstrate significant improvements in charging station efficiency and reliability, highlighting the effectiveness of our proposed control strategies and harmonic mitigation techniques. Notably, the integration of renewable energy sources emerges as a pivotal factor in reducing operational costs and carbon emissions, furthering the sustainability of EV charging solutions. The research delineates the environmental benefits, emphasizing the reduction of greenhouse gas emissions and enhancement of urban air quality, pivotal in the global shift towards cleaner transportation modes. This work contributes valuable insights into the design and grid integration of EV charging stations, offering a scalable model for future infrastructure development. It serves as a critical resource for engineers, policymakers, and stakeholders in the realm of electric mobility, advocating for a strategic transition to EVs supported by robust and efficient charging infrastructure.
Isolation of peptide mixtures with potential biological activities from the protein hydrolysate of Arsenura armida larval meal
Authors: Cortazar-Moya S. , Jiménez-González O. , Bojórquez-Velázquez E. , Ruiz-May E. , López-Malo A. , Morales-Camacho J.I. 
Published: June 2024

Abstract
This study explores using insects as a high-quality protein source rich in bioactive peptides for human nutrition. The objectives include establishing optimal conditions for peptide extraction, identifying their sequences, and assessing their potential as antioxidants and antimicrobial agents in Arsenura armida flour. The protein content in the A. armida flour extract was 54%. To obtain potential antioxidant and antimicrobial peptides, a 10:1 and 1:1 enzyme (pepsin)/substrate ratio was employed, with digestion times of 2 h (A2) and 1 h (A4), respectively. The IC50 value for the antioxidant assay DPPH (2,2-Difenil-1-Picrilhidrazilo) was 22.5 μg/μL for A2. In the antioxidant in vivo assay with Caenorhabditis elegans, A2 peptides at concentrations of 0.75 μg/μL and 1.5 μg/μL exhibited a survival percentage ranging from 32.6% to 35.3%. The A4 sample demonstrated the highest antimicrobial activity, inhibiting the growth of Gram-positive bacteria (Listeria monocytogenes and Staphylococcus aureus) with MIC (minimum inhibitory concentration) values of 0.11 μg/mL and 0.23 μg/mL and MBC (minimum bactericidal concentration) of 0.23 μg/mL for both. Peptide analysis revealed that A2 contained peptides with identified antihypertensive (37%) and antioxidant (58%) activities, while A4 comprised peptides with antihypertensive (62%), antioxidant (31%), and antimicrobial (2%) properties. The antimicrobial peptides identified through the BIOPEP database were LFGF and FLLF. This investigation underscores the potential of A. armida peptides as valuable components in functional foods or nutraceuticals, offering health benefits beyond basic nutrition.
A Biological Spacer to Treat Irreparable Rotator Cuff Tears: A Biomechanical Study Utilizing a Secured Versus Unsecured Tensor Fascia Lata Graft
Authors: Malige Ajith , Tibone James E. , Hui Aaron , Kwak Daniel , Jewell Josh , McGarry Michelle H. , Lee Thay Q. 
Published: June 2024

Background: Designed to help treat pain and loss of function after rotator cuff repair, allograft spacer procedures utilize a graft to act as a spacer in the subacromial space, decreasing pain from impingement of the greater tuberosity on the acromion at the extremes of overhead motion. Purpose: To evaluate the biomechanical characteristics of secured versus unsecured tensor fascia lata allografts used in an allograft spacer procedure. Study Design: Controlled laboratory study. Methods: A total of 8 fresh-frozen cadaveric shoulder specimens were used. There were 4 conditions tested: (1) intact rotator cuff, (2) stage III rotator cuff tear (complete supraspinatus tendon and superior one-half of the infraspinatus tendon), (3) unsecured tensor fascia lata graft, and (4) secured tensor fascia lata graft. Both superior and posterior translation of the humeral head were calculated in each condition. A 4-cm × 5-cm × 6-mm tensor fascia lata graft was used in the subacromial space to act as a spacer. Grafts were secured at the lateral edge of the native rotator cuff footprint with 2 knotless anchors. Results: With unbalanced loading, both secured and unsecured grafts varied in their ability to limit superior and posterior translation at various rotation angles back to levels seen with intact rotator cuffs at 0° and 20° of abduction. During balanced loading, both unsecured and secured grafts limited superior and posterior translation more than those seen in the rotator cuff–deficient condition ( P < .01) and similar to those seen in the intact condition ( P > .05). The secured and unsecured grafts allowed similar amounts of translation at every position with both unbalanced and balanced loading ( P > .05). Finally, total graft motion was <7 mm in all positions. Conclusion: Unsecured tensor fascia lata grafts were biomechanically equivalent to secured grafts when used during allograft spacer procedures. Clinical Relevance: While both grafts were successful at limiting superior and posterior translation of the humeral head during early range of motion, the unsecured graft represents a cheaper, easier option to utilize during allograft spacer procedures.
Adolescents’ Attitude Toward Their Rights, Perceived Parenting Styles, and Predictors of Their Rights in a South Indian Urban Context
Authors: Chetan S. V. , Thomas Bino , Roopesh Bangalore N. 
Published: June 2024

Background: Adolescent rights refer to moral or legal entitlements that are reasonable, justifiable, and include provision (care), protection (safety), and participation (self-expression), which can be categorized as nurturance rights and self- determination rights. Studies from the global north have established links between the rights of children/adolescents and parenting practices, with endorsement of self-determination rights. However, with a changing sociocultural landscape, this concept has received little attention in the Indian context. Aim and Objectives: To explore adolescents’ attitude toward their rights, their relationship with the perceived parenting style, and identifying the predictors of their overall rights in a South Indian metropolitan city. Methods: The sample consisted of 186 adolescents (100 women and 86 men) between 14 and 19 years (median age = 17 years). Modified Child Rights Attitude Questionnaire and Parental Authority Questionnaire – Mother and Father Form were used in the study. The data were analyzed using Wilcoxon’s Test, Kendall’s Tau, and multiple linear regression. Results: The findings indicated that the adolescents expressed a positive attitude toward nurturance rights over self-determination rights. A significant correlation was found between adolescents’ attitude toward overall rights and the perceived parenting styles: fathers’ permissive, authoritarian, and authoritative-flexible parenting styles and mothers’ authoritarian and authoritative-flexible parenting styles. Gender, academic performance, birth order, and time spent with parents emerged as significant predictors of adolescents’ overall attitude toward their rights. Conclusion: The study highlighted the endorsement of nurturance rights by adolescent participants which has potential implications for understanding the rights of adolescents in the contexts of self and family, autonomy, education, and the need for awareness and acknowledgment of rights.
The Dynamic Model of Health Assets: a model development
Authors: Bodryzlova Yuliya , Moullec Gregory , Kelly Michael P. 
Published: June 2024

Aim: Epidemiological research on resistance and resilience can build on models of health developed in health promotion. Nevertheless, these models need to be adjusted to approaches currently employed in epidemiology; namely, included concepts should be easy to operationalize, and links between them should be simple enough to enable statistical modeling. In addition, these models should include both individual and environmental assets. The objective of this study is to consolidate the current knowledge on health assets, adjust them to epidemiological research needs, and propose a new model of health assets for epidemiological studies on health. Design: The conceptual paper was conducted according to the guidelines for the model development. Methods: The development of the new model was made from the perspective of salutogenesis – the branch of health promotion studying the origins of health. The analysis of literature on health promotion, public health, and positive psychology was conducted to find the links connecting individual and environmental assets. Results: The newly developed Dynamic Model of Health Assets circularly links individual characteristics, actions, environments, and support. Each preceding component of the model contributes to the following one; each component also independently contributes to resistance and resilience. The new model may guide large-scale epidemiological research on resistance and resilience. The model’s components are easy to operationalize; the model allows for constructing multilevel models and accounting for the dynamic nature of the relationships between components. It is also generic enough to be adjusted to studying contributors to resistance and resilience to different specific diseases. Conclusion: The new model can guide epidemiological studies on resistance and resilience.
Long-term Outcomes After Open Repair of Humeral Avulsion of the Glenohumeral Ligament
Authors: Dannaway Jasan , Raniga Sumit , Bokor Desmond 
Published: June 2024

Background: There is a lack of data regarding the long-term clinical outcomes of open repair of humeral avulsion of the glenohumeral ligament (HAGL). Purpose: To examine the long-term patient outcomes, prevalence of related shoulder lesions, and return to sports in patients who have had open HAGL repair. Study Design: Case series; Level of evidence, 4. Methods: Included were 47 patients who underwent open repair of an HAGL lesion between 1995 and 2013. Clinical results were assessed using the Western Ontario Shoulder Instability Index (WOSI). Recurrence of instability, additional surgeries, confidence in the shoulder, level and type of sport before and after surgery, and return to sports were documented. Results: The mean follow-up duration was 105 months (range, 16-247 months). The mean postoperative WOSI score was 410. Postoperatively, 10 patients experienced a recurrence of instability. Subgroup analysis of patients who reported recurrence demonstrated significantly worse WOSI scores compared with patients who did not experience recurrence (730 [95% CI, 470-990] vs 320 [95% CI, 210-430], respectively; P = .007). Before surgery, 33 patients participated in competitive sports, compared with 22 patients after surgery. No postoperative neurologic or vascular complications were recorded. In 51% of patients, a labral tear was noted as a concomitant injury. Conclusion: Open repair of an HAGL lesion restored shoulder stability with good results. However, recurrence was significant (21%) with longer follow-up, and return to sports was affected. Associated lesions were prevalent.
Characterization and physicochemical properties of lignocellulosic fibers from Fishtail Palm (Caryota mitis) Leaf Stalks
Authors: Sivanantham Gokulkumar , Sivaraj Vijaya Gurupranes , Murugan Aravindh , Selvaraj Sathish , Thangavelu Kannan , Mani Sasi Kumar , Marappan Sathiya Seelan , Elango Sunitha Sanjay Siva , Purushothaman Geetha Vishnu 
Published: June 2024

Recent advancements in composites involve integrating natural fibers into polymer matrices as a reinforcement or filler. This approach offers several benefits, including eco-friendliness, abundant natural materials, exceptional strength, cost-effectiveness, and simple extraction methods. Substituting synthetic materials with natural ones has environmental advantages, as some synthetics release toxins at high temperatures. Natural materials reduce the risk of toxic emissions, fostering a safer environment. Thus, our research centers on experimentally characterizing Fishtail Palm Leaf Stalk Fiber (FPLSF) through methods like Fourier transform infrared spectroscopy (FT-IR), X-ray diffraction analysis (XRD), thermogravimetric analysis (TGA), single fiber tensile test, and scanning electron microscope (SEM) analysis. These techniques unveil insights into composition, structure, thermal properties, strength, and morphology. Results highlight FPLSF’s attributes: 63.67% cellulose, 1473 kg/m³ density, 380.85 µm diameter, 31.37% crystallinity index, 249.23 MPa tensile strength, and 326°C thermal stability. In addition, the sound absorption properties such as sound absorption coefficient (SAC) and noise reduction coefficient (NRC) are found to be 0.34 and 0.39, respectively. FPLSF’s properties suggest its potential as an alternative reinforcement in composite manufacturing.
GATSol, an enhanced predictor of protein solubility through the synergy of 3D structure graph and large language modeling
Authors: Li Bin , Ming Dengming 
Published: June 2024

Abstract
Background
Protein solubility is a critically important physicochemical property closely related to protein expression. For example, it is one of the main factors to be considered in the design and production of antibody drugs and a prerequisite for realizing various protein functions. Although several solubility prediction models have emerged in recent years, many of these models are limited to capturing information embedded in one-dimensional amino acid sequences, resulting in unsatisfactory predictive performance.

Results
In this study, we introduce a novel Graph Attention network-based protein Solubility model, GATSol, which represents the 3D structure of proteins as a protein graph. In addition to the node features of amino acids extracted by the state-of-the-art protein large language model, GATSol utilizes amino acid distance maps generated using the latest AlphaFold technology. Rigorous testing on independent eSOL and the Saccharomyces cerevisiae test datasets has shown that GATSol outperforms most recently introduced models, especially with respect to the coefficient of determination R2, which reaches 0.517 and 0.424, respectively. It outperforms the current state-of-the-art GraphSol by 18.4% on the S. cerevisiae_test set.

Conclusions
GATSol captures 3D dimensional features of proteins by building protein graphs, which significantly improves the accuracy of protein solubility prediction. Recent advances in protein structure modeling allow our method to incorporate spatial structure features extracted from predicted structures into the model by relying only on the input of protein sequences, which simplifies the entire graph neural network prediction process, making it more user-friendly and efficient. As a result, GATSol may help prioritize highly soluble proteins, ultimately reducing the cost and effort of experimental work. The source code and data of the GATSol model are freely available at https://github.com/binbinbinv/GATSol.
Integrated transcriptomics and metabolomics study of embryonic breast muscle of Jiaji ducks
Authors: Gu Lihong , Chen Jile , Hu Chengjun , Wang Dingfa , Huan Shuqian , Rong Guang , Lv Renlong , Xu Tieshan 
Published: June 2024

AbstractBecause number of matured muscle fibers in poultry does not increase after birth, the meat yield is mainly determined during embryogenesis. We previously indicated breast muscle grew rapidly from 18th day after hatching (E18) to E27, and almost stopped from E27 to E34 of Jiaji ducks, while the mechanism is unclear. This study utilized RNA-seq to explore the related genes of muscle development and their relationship with small molecule metabolites at E18, E27 and E34 of Jiaji ducks. Several thousand differentially expressed genes (DEGs) were detected among E18, E27 and E34. DEGs expression profiles included 8 trend maps, among which trend 1 was opposite to and trend 6 was consistent with breast muscle development trend of Jiaji ducks. Through joint analysis between trend 1 of DEGs and trend 1 of differential metabolites (DEMs), protein digestion and absorption pathway stood out. The decrease of COL8A2 gene expression will lead to the decrease of arginine content, which will inhibit the development of breast muscle in embryonic Jiaji duck. Similarly, joint analysis between trend 6 of DEGs and trend 6 of DEMs indicated the increase of GAMT gene expression will cause the increase of proline content, and then promote the development of breast muscle of Jiaji duck in embryonic period. These results will be helpful for further understanding the mechanism of muscle yields of Jiaji ducks.