bluuebunny/crossref_metadata_2025_split huggingface dataset:
Aggression, Capitalism, and International Law: Missed Opportunities or Structural Constraints?
Authors: Tzouvala Ntina 
Published: June 2024

Abstract
The recent revival of geopolitical competition has been accompanied by the meteoric rise of military spending across the globe. In light of this development, this article advances three claims. First, I posit that the political economy of war should be of concern to international lawyers and to anyone who is committed to peace. Second, I show that international law has been consistently unsuccessful and is currently singularly unambitious when it comes to naming, regulating, and sanctioning the political economy of war. Finally, I argue that the consistent failure of the field cannot be wholly attributed to historical contingencies. Rather, this is because armaments exist in the intersection of two logics, the logic of the state and the logic of the market, that have mystifying effects, even though the modalities of obfuscation are markedly different. The logic of the state makes the political economy of war hard to counter by law because it treats it as too exceptional, while the logic of the market does the same but by treating it as too pedestrian and ordinary. This convergence of logic creates layers of obfuscation that are not reducible to (international) law, but (international) law can nevertheless play a role in making it more or less opaque.
On The Security Of A Novel Construction Of Certificateless Aggregate Signature Scheme For Healthcare Wireless Medical Sensor Networks
Authors: Yan Zhen , Qu Haipeng , Lin Xi-Jun 
Published: June 2024

Abstract
Recently, Qiao et al. proposed a novel construction of certificateless aggregate signature (CLAS) scheme to ensure the integrity and authenticity of medical data in healthcare wireless medical sensor networks (HWMSNs). They first created an underlying certificateless signature (CLS) scheme, and then proposed a CLAS scheme from the underlying CLS scheme by adding an aggregation algorithm and a verification algorithm. In this paper, we point out that their CLS scheme is insecure because the Type I adversary can forge valid signatures. That is, the unforgeability is not actually captured by their CLS scheme. Finally, we map our cryptanalysis to the practical application. That is, in the practical application of HWMSNs, the attacker can launch real attack to their CLS scheme using our cryptanalysis to forge signatures. Therefore, Qiao et al.’s CLS scheme can be totally broken.
Examining the Psychometric Properties of the Student Behavior Checklist-Brief’s Subject Scores: Tests of Measurement Invariance
Authors: Steggerda Jake C , Rueger Sandra Yu , Bridges Ana J 
Published: June 2024

Abstract
Authors evaluated the Student Behavior Checklist-Brief (SBC-B) to test whether teacher-reports of student learning approach (i.e., learned helplessness [LH] and mastery orientation [MO]) were invariant across academic subjects. The current sample includes ethnically diverse seventh and eighth grade students (N = 145; 53 percent male) and six teams of five teachers for the core academic subjects. Authors conducted confirmatory factor analyses and measurement invariance tests on ratings for each of the subject-specific SBC-B measures and total SBC-B ratings that were not subject-specific. Results supported full measurement invariance across academic subjects. This evidence supporting the SBC-B’s psychometric properties across subjects increases confidence in using the measure in research and clinical settings to identify youth with tendencies toward LH or MO and explore how LH/MO relate to academic functioning and experiences of internalizing symptoms.
Central memory CD4+ T cells play a protective role against immune checkpoint inhibitor–associated myocarditis
Authors: Yu Jiajun , Long Bo , Li Ziyong , Tian Xiaolong , Li Dairong , Long Jianling , Wang Yujue , Chen Yue , Zhang Fang , Liu Haixia , Qian Cheng , Shan Juanjuan 
Published: June 2024

Abstract

Aims
The widespread use of immune checkpoint inhibitors (ICIs) has demonstrated significant survival benefits for cancer patients and also carries the risk of immune-related adverse events. ICI-associated myocarditis is a rare and serious adverse event with a high mortality rate. Here, we explored the mechanism underlying ICI-associated myocarditis.

Methods and results
Using the peripheral blood of patients with ICI therapy and of ICI-treated mice with transplanted tumours, we dissect the immune cell subsets and inflammatory factors associated with myocarditis. Compared to the control group, patients with myocarditis after ICI therapy showed an increase in NK cells and myeloid cells in the peripheral blood, while T cells significantly decreased. Among T cells, there was an imbalance of CD4/CD8 ratio in the peripheral blood of myocarditis patients, with a significant decrease in central memory CD4+ T (CD4+ TCM) cells. RNA sequencing revealed that CD4+ TCM cells in myocarditis patients were immunosuppressive cell subsets, which highly express the immunosuppressive factor IL-4I1. To elucidate the potential mechanism of the decrease in CD4+ TCM cells, protein array was performed and revealed that several inflammatory factors gradually increased with the severity of myocarditis in the myocarditis group, such as IL-1B/CXCL13/CXCL9, while the myocardial protective factor IL-15 decreased. Correlation analysis indicated a positive correlation between IL-15 and CD4+ TCM cells, with high expression of IL-15 receptor IL15RA. Furthermore, in vivo studies using an anti-PDL1 antibody in a mouse tumour model indicated a reduction in CD4+ TCM cells and an increase in effector memory-expressing CD45RA CD8+ T (TEMRA) cells, alongside evidence of cardiac fibrosis. Conversely, combining anti-PDL1 antibody treatment with IL-15 led to a resurgence of CD4+ TCM cells, a reduction in CD8+ TEMRA cells, and a mitigated risk of cardiac fibrosis.

Conclusion
Our data highlight CD4+ TCM cells’ crucial role in cardiac protection during ICI therapy. IL-15, IL-4I1, and CD4+ TCM cells can serve as therapeutic targets to reduce ICI-associated myocarditis in cancer patients.
Survey of Leafminers on American Chestnut and other Castanea spp. (Fagales: Fagaceae) on Long Island, NY
Authors: Hough Karissa E , Eiseman Charles S , Perreault Stephane , McGuinness Hugh , Burke Russell L , Nieto-Fernandez Fernando E 
Published: June 2024

Abstract
The effect of the 20th-century functional extinction of the American Chestnut (Fagaceae: Castanea dentata (Marshall) Borkh) on associated herbivorous insects is unknown. These insects include leafminers that spend at least part of their larval phase feeding between the epidermises of leaves. We surveyed leafminers on C. dentata, nonnative Castanea spp., and hybrids on Long Island, NY. We found 10 leafminer species feeding on Castanea spp. A first New York State record was documented for Stigmella castaneaefoliella (Chambers) (Lepidoptera: Nepticulidae). New host records are established for 6 lepidopterans, including a new host genus for Phyllonorycter basistrigella (Clemens) (Lepidoptera: Gracillariidae). We found no significant differences in the mean intensity of S. castaneaefoliella leaf mines on native and nonnative Castanea spp.; however, our sample size was small. Thus, we guardedly conclude that nonnative Castanea spp. can serve as refugia for C. dentata leafminers native to North America while acknowledging that the extent to which nonnative species are utilized requires further investigation.
Establishment and validation of an extracellular volume model without blood sampling in ST-segment elevation myocardial infarction patients
Authors: Chen Lei , Zhang Zeqing , Du Xinjia , Liu Jiahua , Liu Zhongxiao , Chen Wensu , Che Wenliang 
Published: June 2024

Abstract

Aims
Recent studies have shown that extracellular volume (ECV) can also be obtained without blood sampling by the linear relationship between haematocrit (HCT) and blood pool R1 (1/T1). However, whether this relationship holds for patients with myocardial infarction is still unclear. This study established and validated an ECV model without blood sampling in ST-segment elevation myocardial infarction (STEMI) patients.

Methods and results
A total of 398 STEMI patients who underwent cardiac magnetic resonance (CMR) examination with T1 mapping and venous HCT within 24 h were retrospectively analysed. All patients were randomly divided into a derivation group and a validation group. The mean CMR scan time was 3 days after primary percutaneous coronary intervention. In the derivation group, a synthetic HCT formula was obtained by the linear regression between HCT and blood pool R1 (R2 = 0.45, P &lt; 0.001). The formula was used in the validation group; the results showed high concordance and correlation between synthetic ECV and conventional ECV in integral (bias = −0.12; R2 = 0.92, P &lt; 0.001), myocardial infarction site (bias = −0.23; R2 = 0.93, P &lt; 0.001), and non-myocardial infarction sites (bias = −0.09; R2 = 0.94, P &lt; 0.001).

Conclusion
In STEMI patients, synthetic ECV without blood sampling had good consistency and correlation with conventional ECV. This study might provide a convenient and accurate method to obtain the ECV from CMR to identify myocardial fibrosis.
A King Praises Himself: The Letters of Charles the Bald to Pope Hadrian II
Authors: Pecksmith Robert 
Published: June 2024

Abstract
In 871–2 two letters were dispatched in the name of the West Frankish king Charles the Bald to Pope Hadrian II. These letters have long been of interest to historians for their rigorous defence of royal sovereignty in the face of an increasingly intrusive papacy, and their authorship has often been ascribed to Charles’s prolific archbishop, Hincmar of Rheims. This article argues that these letters should be read from a different perspective, prioritising the tone taken by the author of the letters. By exploring the author’s ideas about honourable forms of address and the avoidance of harsh censure, I argue that these letters show the guiding hand of Charles himself, revealing a view of royal power not only as an institution, but also as a status that necessarily had to be approached with deference and praise. Close examination of Charles’s argument suggests that his identification with contemporary panegyrics, above all those by his Irish praise poet Sedulius Scottus, informed his perspective on the dignity of his royal office and led him to respond aversely to papal criticism that threatened to undermine his legitimacy as ruler. Hadrian’s transition from harsh rebuke to sycophancy across his letters suggests that Charles’s diplomatic successes with the papacy were also accompanied by papal recognition of his exalted, quasi-imperial status through laudatory address.
The Short- and Long-Run Impacts of Free Education on Schooling: Direct Effects and Intra-Household Spillovers
Authors: Guo Naijia , Wang Shuangxin , Zhang Junsen 
Published: June 2024

Abstract
This study estimates the direct and spillover effects of a free education programme on educational outcomes in rural China. We find that, although the programme encourages more eligible children to attend secondary school, it also leads to a decrease in high school enrolment among ineligible girls with eligible siblings, as they are more likely to choose work instead. In the long run, males exposed to free education have more years of schooling than their non-exposed counterparts. However, such effect is not found among females. This disparity suggests that a gender-neutral policy may have an asymmetric effect between males and females because of spillover effects through intra-household resource allocation.
Long-distance movement dynamics shape host microbiome richness and turnover
Authors: Pearman William S , Duffy Grant A , Gemmell Neil J , Morales Sergio E , Fraser Ceridwen I 
Published: June 2024

Abstract
Host-associated microbial communities are shaped by host migratory movements. These movements can have contrasting impacts on microbiota, and understanding such patterns can provide insight into the ecological processes that contribute to community diversity. Furthermore, long-distance movements to new environments are anticipated to occur with increasing frequency due to host distribution shifts resulting from climate change. Understanding how hosts transport their microbiota with them could be of importance when examining biological invasions. Although microbial community shifts are well-documented, the underlying mechanisms that lead to the restructuring of these communities remain relatively unexplored. Using literature and ecological simulations, we develop a framework to elucidate the major factors that lead to community change. We group host movements into two types—regular (repeated/cyclical migratory movements, as found in many birds and mammals) and irregular (stochastic/infrequent movements that do not occur on a cyclical basis, as found in many insects and plants). Ecological simulations and prior research suggest that movement type and frequency, alongside environmental exposure (e.g. internal/external microbiota) are key considerations for understanding movement-associated community changes. From our framework, we derive a series of testable hypotheses, and suggest means to test them, to facilitate future research into host movement and microbial community dynamics.
Methane production from the biodegradation of lignite with different sizes by mixed fungi-methanogen microflora
Authors: Gao Longzhen , Feng Xiao , Zhang Yixuan , Guo Hongguang , Mu Xiaogang , Huang Zaixing , Urynowicz Michael 
Published: June 2024

Abstract
Biogenic coalbed methane (CBM) is a developing clean energy source. However, it is unclear how the mechanisms of bio-methane production with different sizes of coal. In this work, pulverized coal (PC) and lump coal (LC) were used for methane production by mixed fungi-methanogen microflora. The lower methane production from LC was observed. The aromatic carbon of coal was degraded slightly by 2.17% in LC, while 11.28% in PC. It is attributed to the proportion of lignin-degrading fungi, especially Penicillium, which was reached 67.57% in PC on the 7th day, higher than that of 11.38% in LC. The results suggested that the limited interaction area in LC led to microorganisms hardly utilize aromatics. It also led the accumulation of aromatic organics in the fermentation broth in PC. Increasing the reaction area of coal and facilitating the conversion of aromatic carbon are suggested means to increase methane production in situ.
SSR marker-based individual identification system to trace illegal logging and geographic origin of teak (Tectona grandis L.f.) wood in India
Authors: Balakrishnan Swathi , Unnikrishnan Remya , Ramasamy Yasodha , Dev Suma Arun 
Published: June 2024

Abstract
Illegal tree felling is one of the crucial problems in forestry worldwide. It is essential to develop adequate forensic techniques that can verify the origin of timber sourced at logging concessions. Teak wood—one of the most important timber species in India—is often illegally logged and also imported from other countries without certification. In our study, the best combination of Simple Sequence Repeat (SSR) markers identified was utilized for match testing the genetic profiles of seized and evidence woods. A genetic reference database was also developed to assign unknown wood samples to their source populations. Our results found a perfect match between the genetic profiles of seized wood and their respective evidence wood which ascertains the utility of genetic profiles as an efficient forensic tool. Further, efficiency of assignment tools based on different approaches such as distance-based, model-based and machine learning were tested. Mycorrhiza, a machine learning algorithm, was identified as the best assignment tool. However, only broad provenance-level assignment was possible due to the genetic admixture in a few natural teak populations. Mycorrhiza was then used to identify the origin of two plantations in India. The assignment test predicted that both the plantations had similar origin, having sourced seeds from multiple natural populations (through clonal seed orchards and seed production areas) and local populations in different ratio. The SSR markers and assignment tool from this study can be used as an effective forensic tool to curb illegal felling and to verify integrity of timber supply chains in India. Also, provenance-based assignment guarantees usage of these markers in a global scale. However, a collective global effort to develop and deposit a robust reference database in a common repository is a prerequisite to strengthen timber traceability worldwide.
Comparison of accelerated and standard infliximab induction regimens in acute severe ulcerative colitis using propensity score analysis: a retrospective multicenter study in China
Authors: Liu Xinyu , Li Hui , Tian Feng , Xie Ying , Zhang Xiaoqi , Zhi Min , Zhang Min , Song Xiaomei , Guo Hong , Li Xiaofei , Liang Jie , Shen Jun , Li Yue 
Published: June 2024

Abstract

Background
The optimal regimen of infliximab salvage in acute severe ulcerative colitis (ASUC) patients remains controversial. This study aimed to compare accelerated and standard infliximab induction in Chinese ASUC patients, and to explore risk factors and concrete accelerated regimens for them.

Methods
Data were retrospectively collected from steroid-refractory ASUC patients receiving infliximab as rescue therapy at seven tertiary centers across China. Outcomes including colectomy and clinical remission (Mayo score ≤ 2 and every subscore ≤ 1 at Day 14) rates were compared between patients receiving accelerated and standard infliximab induction using propensity score adjustment for potential confounders. The dose–response relationship was explored by plotting restricted cubic splines. Logistic regression and Cox proportional hazards regression analyses were performed to determine risk factors for adverse outcomes. A systematic review and meta-analysis was also performed.

Results
A total of 76 patients were analysed: 29 received standard and 47 received accelerated induction. The accelerated group had a higher 90-day colectomy rate (17.8% vs 0%, P = 0.019) and lower clinical remission rate (27.7% vs 65.5%, P = 0.001). After adjusting for propensity score and institution, there was no significant difference in colectomy or clinical remission rates (both P &gt; 0.05). Dose–effect curves showed decreased colectomy hazard with higher cumulative infliximab dosage within 5 days, with no improvement observed for increasing cumulative infliximab dosage within 28 days. Multivariate logistic regression analyses revealed C-reactive protein of &gt;10 mg/L at infliximab initiation (odds ratio = 5.00, 95% confidence interval: 1.27–24.34) as an independent risk factor for no clinical remission. Meta-analysis also revealed no significant difference in colectomy rates at 3 months (P = 0.54).

Conclusions
After adjusting for confounders, there were no significant differences in colectomy or clinical remission rates between accelerated and standard infliximab induction among ASUC patients. Early administration of an intensified dosage within 5 days may be beneficial. Elevated C-reactive protein at infliximab initiation indicated need for intensive treatment.
Pseudomonas putida Dynamics of Adaptation under Prolonged Resource Exhaustion
Authors: Gross Jonathan , Katz Sophia , Hershberg Ruth 
Published: June 2024

Abstract
Many nonsporulating bacterial species survive prolonged resource exhaustion, by entering a state termed long-term stationary phase. Here, we performed long-term stationary phase evolutionary experiments on the bacterium Pseudomonas putida, followed by whole-genome sequencing of evolved clones. We show that P. putida is able to persist and adapt genetically under long-term stationary phase. We observed an accumulation of mutations within the evolving P. putida populations. Within each population, independently evolving lineages are established early on and persist throughout the 4-month-long experiment. Mutations accumulate in a highly convergent manner, with similar loci being mutated across independently evolving populations. Across populations, mutators emerge, that due to mutations within mismatch repair genes developed a much higher rate of mutation than other clones with which they coexisted within their respective populations. While these general dynamics of the adaptive process are quite similar to those we previously observed in the model bacterium Escherichia coli, the specific loci that are involved in adaptation only partially overlap between P. putida and E. coli.
Ablation of the dystrophin Dp71f alternative C-terminal variant increases sarcoma tumour cell aggressiveness
Authors: Alnassar Nancy , Hajto Jacek , Rumney Robin M H , Verma Suraj , Borczyk Malgorzata , Saha Chandrika , Kanczler Janos , Butt Arthur M , Occhipinti Annalisa , Pomeroy Joanna , Angione Claudio , Korostynski Michal , Górecki Dariusz C 
Published: June 2024

Abstract
Alterations in Dp71 expression, the most ubiquitous dystrophin isoform, have been associated with patient survival across tumours. Intriguingly, in certain malignancies, Dp71 acts as a tumour suppressor, while manifesting oncogenic properties in others. This diversity could be explained by the expression of two Dp71 splice variants encoding proteins with distinct C-termini, each with specific properties. Expression of these variants has impeded the exploration of their unique roles. Using CRISPR/Cas9, we ablated the Dp71f variant with the alternative C-terminus in a sarcoma cell line not expressing the canonical C-terminal variant, and conducted molecular (RNAseq) and functional characterisation of the knockout cells. Dp71f ablation induced major transcriptomic alterations, particularly affecting the expression of genes involved in calcium signalling and ECM-receptor interaction pathways. The genome-scale metabolic analysis identified significant downregulation of glucose transport via membrane vesicle reaction (GLCter) and downregulated glycolysis/gluconeogenesis pathway. Functionally, these molecular changes corresponded with, increased calcium responses, cell adhesion, proliferation, survival under serum starvation and chemotherapeutic resistance. Knockout cells showed reduced GLUT1 protein expression, survival without attachment and their migration and invasion in vitro and in vivo were unaltered, despite increased matrix metalloproteinases release. Our findings emphasise the importance of alternative splicing of dystrophin transcripts and underscore the role of the Dp71f variant, which appears to govern distinct cellular processes frequently dysregulated in tumour cells. The loss of this regulatory mechanism promotes sarcoma cell survival and treatment resistance. Thus, Dp71f is a target for future investigations exploring the intricate functions of specific DMD transcripts in physiology and across malignancies.