bluuebunny/crossref_metadata_2025_split huggingface dataset:
An everolimus‐eluting stent versus a paclitaxel‐eluting stent in small vessel coronary artery disease: A pooled analysis from the SPIRIT II and SPIRIT III trials
Authors: Bartorelli Antonio L. , Serruys Patrick W. , Miquel‐Hébert Karine , Yu Shui , Pierson Wes , Stone Gregg W. ,   on behalf of the SPIRIT II SPIRIT III Investigators
Published: January 2010

AbstractObjectives: To evaluate the safety and efficacy of the XIENCE V everolimus‐eluting stent compared to the TAXUS paclitaxel‐eluting stent in small vessels. Backgroud: The XIENCE V everolimus‐eluting stent (EES) has been shown to improve angiographic and clinical outcomes after percutaneous myocardial revascularization, but its performance in small coronary arteries has not been investigated. Methods: In this pooled analysis, we studied a cohort of 541 patients with small coronary vessels (reference diameter <2.765 mm) by using patient and lesion level data from the SPIRIT II and SPIRIT III studies. TAXUS Express (73% of lesions) and TAXUS Liberté (27% of lesions) paclitaxel‐eluting stents (PES) were used as controls in SPIRIT II. In SPIRIT III, Taxus Express2 PES was the control. Results: Mean angiographic in‐stent and in‐segment late loss was significantly less in the EES group compared with the PES group, (0.15 ± 0.37 mm vs. 0.30 ± 0.44 mm; P = 0.011 for in‐stent; 0.10 ± 0.38 mm vs. 0.21 ± 0.34 mm; P = 0.034 for in‐segment). EES also resulted in a significant reduction in composite major adverse cardiac events at 1 year (19/366 [5.2%] vs. 17/159 [10.7%]; P = 0.037), due to fewer non‐Q‐wave myocardial infarctions and target lesion revascularizations. At 1 year, the rate of non‐Q‐wave myocardial infarction was significantly lower in the EES group compared with that of the PES group (6/366 [1.6%] vs. 8/159 [5.0%]; P = 0.037). Conclusions: In patients with small vessel coronary arteries, the XIENCE V EES was superior to the TAXUS PES. © 2010 Wiley‐Liss, Inc.
Ischemic cardiac complications following G‐CSF
Authors: Eckman Peter M. , Bertog Stefan C. , Wilson Robert F. , Henry Timothy D. 
Published: January 2010

AbstractGranulocyte‐colony stimulating factor (G‐CSF) is commonly used in bone marrow transplant donors to increase the number of circulating progenitor cells. G‐CSF has also been studied following myocardial infarction, but concern has been raised about the risks of G‐CSF administration in patients with coronary artery disease. We present two cases of ischemic cardiac complications that are likely to be related to administration of G‐CSF and provide a contemporary overview of the literature on the cardiovascular risks of G‐CSF. © 2010 Wiley‐Liss, Inc.
Distal stent delivery with guideliner catheter: First in man experience
Authors: Mamas Mamas A. , Fath‐Ordoubadi Farzin , Fraser Douglas G. 
Published: January 2010

AbstractFailure to deliver stents is one of the commonest causes of procedural failure in contemporary PCI practice. We describe successful use of the Guideliner Catheter, the first purpose designed FDA and CE marked device delivery catheter in 13 complex cases in native coronary vessels and bypass grafts performed via the radial route to enable distal stent delivery following failure of conventional techniques. We discuss how the Guideliner catheter may be used to facilitate difficult radial cases. © 2010 Wiley‐Liss, Inc.
Reconfiguration of the Amplatzer Vascular Plug II 5 months after occlusion of venovenous collateral in a bidirectional cavopulmonary circulation
Authors: Sheridan Bennett , Ward Cameron , Justo Robert 
Published: January 2010

AbstractVenovenous anomalous vessels are a common complication seen in the bidirectional cavopulmonary circulation. In this report, we describe the use of the Amplatzer Vascular Plug II and subsequent demonstration of nitinol device memory with significant device reconfiguration at 5 months follow‐up. © 2010 Wiley‐Liss, Inc.
Early recognition of catheter‐induced left main coronary artery vasospasm: Implications for revascularization
Authors: Edris Ahmad , Patel Pranav M. , Kern Morton J. 
Published: January 2010

AbstractCatheter‐induced left main coronary artery (LMCA) vasospasm is a rare complication of coronary angiography that confounds the decision for coronary artery bypass graft (CABG) surgery. We report two cases of catheter‐induced LMCA vasospasm. The first case was a 68‐year‐old woman who presented 6 years after CABG for presumed severe LMCA atherosclerotic disease. Coronary angiography demonstrated totally occluded CABGs and normal native coronary arteries, including a normal LMCA. The second case was a 56‐year‐old man with severe LMCA stenosis, who was scheduled for unprotected LM percutaneous coronary intervention (PCI). Repeat angiography 2 days later showed no stenosis. These cases emphasize the need for meticulous technique and a high index of suspicion of LMCA vasospasm. Intravascular ultrasound (IVUS) at the time of angiography may help to identify minimal atherosclerotic disease suggesting vasospasm. Alternatively, noninvasive testing, such as Computed Tomography (CT) angiography, may diagnose LM spasm in these patients prior to CABG surgery. © 2010 Wiley‐Liss, Inc.
Incidence of stroke in patients with d‐transposition of the great arteries that undergo balloon atrial septostomy in the University Healthsystem Consortium Clinical Data Base/Resource Manager
Authors: Applegate Stacey E. , Lim D. Scott 
Published: January 2010

AbstractObjectives:The aim of this study was to investigate the incidence of stoke in pediatric patients undergoing a balloon atrial septostomy (BAS).Background:Newborn infants with d‐transposition of the great arteries (dTGA) can be compromised from significant hypoxemia due to inadequate mixing at the atrial level. BAS can be lifesaving by improving the intra‐atrial mixing. BAS, although life‐saving, is associated with risks including arrhythmias, infection, bleeding, stroke, or death. Recent studies have conflicting conclusions demonstrating the risk of BAS and brain injury using magnetic resonance imaging. However, these studies did not demonstrate the clinical significance of brain injury through physical manifestations of stroke.Methods:The University HealthSystem Consortium Clinical Data Base/Resource Manager (UHC CDB/RM) consists of 103 Academic Medical Centers, and affiliated institutions. The CDB/RM was queried using billing codes upon discharge from the consortium hospitals from 2004 to 2008.Results:In total, the UHC CDB/RM contained information on 1,295 neonatal patients (group 1) who were discharged with a diagnosis of dTGA, of which 440 had a BAS during the same hospitalization. In group 1, 18 had a coded diagnosis of stroke and only six of these 18 had a BAS. In group 2 (pediatric patients with dTGA), 952 patients were discharged with a diagnosis of dTGA, of which 37 had BAS. Pediatric patients (19 of 952) had a stroke and none of them had a BAS.Conclusions:In over 2,000 cases of dTGA reported in the CDB/RM over a 4‐year period, BAS was not associated with an increased risk of clinical stroke either in the neonatal period or in follow‐up hospitalizations. © 2009 Wiley‐Liss, Inc.
Decreasing operators' radiation exposure during coronary procedures
Authors: Behan Miles , Haworth Peter , Colley Paul , Brittain Michael , Hince Andrew , Clarke Michael , Ghuran Azad , Saha Mrinal , Hildick‐Smith David 
Published: January 2010

AbstractAim: Transradial coronary procedures are associated with decreased vascular access site complications and other benefits compared to the femoral approach. There is some concern however about high‐recorded radiation doses for interventional cardiologists using the transradial route. We therefore designed and investigated the effect of a transradial radiation protection board (TRPB) on operator radiation exposure during coronary procedures. Methods and Results: One hundred and six patients were randomly assigned by time period to undergo radial coronary procedures either with or without a TRPB. This is a grooved arm board with a detachable 0.5‐mm lead equivalent shield designed to rest between the patient's arm and side. Individual case‐specific radiation exposures were measured using electronic personal dosimeter worn on the left outer pocket of the lead apron at chest level. The TRPB was used in addition to standard lead apron and thyroid shielding, below‐table leaded flaps, and leaded glass. Operator radiation exposure was significantly decreased in the TRPB group overall: 28 [18–65] μSV versus 19.5 [10.5–35] μSV, P = 0.003. There were no significant differences in procedure duration, total fluoroscopy dose, or contrast load between the two groups. Conclusion: Identification of methods to reduce operator radiation dose is important. The use of the TRPB can significantly reduce radiation exposure to radial operators. © 2010 Wiley‐Liss, Inc.
Failure of the Amplatzer ductal occluder II
Authors: Beck Carsten , Laser Kai Thorsten , Haas Nikolaus A. 
Published: January 2010

AbstractSince March 2008, the new Amplatzer duct occluder II (ADO II) has been used clinically for PDA closure in Europe. We report an interesting case of a 2½‐year‐old girl with a 3‐mm conical shape PDA (type A PDA) who underwent uneventful implantation of 3/4 ADO II with complete closure by angiography and echocardiographic control at the end of the procedure. To our surprise, echocardiography 24 hr later revealed a moderate secondary shunt due to kinking of the aortic retention disk of the device with the central waist and the pulmonary retention disk still in correct position. The persistent shunt was closed 1 year later in the cath lab with a 9/6 Nit‐Occlud device. To our knowledge, this is the first reported late complication directly related to the device. © 2010 Wiley‐Liss, Inc.
Optimization of drug‐eluting balloon use for safety and efficacy: Evaluation of the 2nd generation paclitaxel‐eluting DIOR‐balloon in porcine coronary arteries
Authors: Pósa Anikó , Nyolczas Noemi , Hemetsberger Rayyan , Pavo Noemi , Petnehazy Örs , Petrasi Zsolt , Sangiorgi Giuseppe , Gyöngyösi Mariann 
Published: January 2010

AbstractObjectives: The aim of this preclinical study was to optimize the use of drug‐eluting balloon (DEB) DIOR2nd
generation by measurements of tissue and plasma paclitaxel concentrations in porcine coronary artery overstretch and prove efficacy in inhibition of neointimal growth without complementary use of stent. Background: The usually recommended DEB 60 sec inflation time causes prolonged ischemia and arterial injury. Methods: Tissue, plasma, and balloon surface concentrations of paclitaxel were measured in pigs 45 min and 12 hr after balloon inflation times of 15, 20, 30, 45, and 60 sec. Extent of neointimal hyperplasia was compared using DIOR2nd
generation or noncoated balloon at two‐week follow‐up. Paclitaxel was replaced by fluorescent paclitaxel derivative in DEB and DES to demonstrate the distribution of the drug in arterial wall. Results: DIOR2nd
generation DEB provided 29 ± 3 μM/L, 52 ± 6 μM/L, 196 ± 44 μM/L, 202 ± 36 μM/L, and 184 ± 59 μM/L paclitaxel to the vessel wall after 15, 20, 30, 45, and 60 sec of dilation, reaching plateau at 30 sec inflation time. Paclitaxel penetrated up to 2 mm tissue deepness. Measurable plasma paclitaxel level (45 ± 28 ng/mL) was found only after 60 sec balloon inflation time. At follow‐up, the dilated arterial segment neointimal area and maximal neointimal thickness were significantly smaller with DIOR vs. uncoated balloon use. Fluorescence images of DIOR showed a homogenous distribution of the drug on the vessel, in contrast with DES. Conclusion: Using the DIOR2nd
generation DEB, a maximal balloon inflation time of 30–45 sec is optimal, reducing effectively the neointimal hyperplasia. © 2010 Wiley‐Liss, Inc.
Predictors of embolization during protected renal artery angioplasty and stenting: Role of antiplatelet therapy
Authors: Kanjwal Khalil , Cooper Christopher J. , Virmani Renu , Haller Steven , Shapiro Joseph I. , Burket Mark W. , Steffes Michael , Brewster Pamela , Zhang Haifeng , Colyer William R. 
Published: January 2010

AbstractObjective: The objective of this study was to identify the predictors of distal embolization (DE) during protected renal artery angioplasty and stenting. Background: DE may contribute to worsening renal function after renal artery stenting. The factors associated with DE, rates of platelet‐rich emboli, and treatments that may prevent DE during renal stenting have not been evaluated. Methods: The current study evaluated patients randomized to receive an embolic protection device (EPD) in the RESIST trial. Forty‐two patients were identified for inclusion in this study. These patients were further randomized to abcizimab (N = 22) or placebo (N = 20). Modification in Diet in Renal Disease glomerular filtration rate (GFR) was used as the primary measure of renal function. Creatinine was measured by a modified Jaffe reaction using the IDMS‐traceable assay. The primary endpoint was capture of platelet rich emboli in the angioguard basket. Results: DE occurred in 15/42 (35%) of the patients and platelet rich DE in 10 (24%) of the patients who received an EPD. Of the angiographic characteristics only lesion length was significantly higher in patients with DE (16 ± 7 mm vs. 10 ± 5 mm, P = 0.04). Preprocedural abciximab reduced DE from 42 to 8% (P = 0.02). The rate of platelet rich emboli was 50% with neither abciximab nor a thienopyridine, 36% with thienopyridine only, 15% abciximab only, and 0% in patients who received both a thienopyridine and abciximab. Only Abciximab use was associated with improved renal function at 1‐month, thienopyridine was not. Angiographic characteristics including percent stenosis, minimal luminal diameter (MLD), reference diameter, change in MLD, contrast volume, and procedure time were not predictors of DE during renal stenting. Conclusion: Capture of DE and specifically platelet DE are common during protected renal stenting using a filter‐type EPD. Abciximab use, and potentially combined thienopyridine and abciximab use, decreased the rate of platelet rich DE; however, only abciximab improved renal function at 1‐month. © 2010 Wiley‐Liss, Inc.
Race, ethnicity, and socioeconomic status influence the survival of patients with hepatocellular carcinoma in the United States
Authors: Artinyan Avo , Mailey Brian , Sanchez‐Luege Nicelio , Khalili Joshua , Sun Can‐Lan , Bhatia Smita , Wagman Lawrence D. , Nissen Nicholas , Colquhoun Steven D. , Kim Joseph 
Published: January 2010

AbstractBACKGROUND:Racial, ethnic, and socioeconomic disparities in the survival of patients with hepatocellular carcinoma (HCC) continue to exist. The authors of this report hypothesized that these differences result from inequities in access to care and in response to therapy.METHODS:Patients with HCC (n = 20,920) were identified from the Surveillance, Epidemiology, and End Results (SEER) database, and patients who underwent liver transplantation for HCC (n = 4735) were identified from the United Network for Organ Sharing (UNOS) database. Clinical and pathologic factors were compared after patients were stratified by race and ethnicity.RESULTS:The survival of patients with HCC improved over time for all racial, ethnic, and income groups (P < .001). Black and low income individuals had the poorest long‐term survival (P < .001). On multivariate analysis, black race was predictive of the poorest survival (hazard ratio [HR], 1.15; 95% confidence interval [CI], 1.09‐1.22; P < .001), whereas Asian race was associated with the best survival (HR, 0.87; 95% CI, 0.83‐0.91; P < .001). After liver transplantation, black patients had the worst graft survival and overall survival (median survival [MS], 30.5 months and 39.7 months, respectively; P < .001), whereas Hispanics had the best survival (MS, 83.4 months and 86.6 months, respectively; P < .001). In a multivariate analysis of transplantation patients, race and ethnicity were associated significantly with outcome.CONCLUSIONS:Significant racial and ethnic disparities in the outcome of patients with HCC persist despite the receipt of comparable treatment. The authors concluded that further investigations are warranted to identify the reasons for the stark disparity in outcomes between black patients and Hispanic patients after liver transplantation for HCC. Cancer 2010. © 2010 American Cancer Society.
Prostate cancer treatment for economically disadvantaged men
Authors: Parsons J. Kellogg , Kwan Lorna , Connor Sarah E. , Miller David C. , Litwin Mark S. 
Published: January 2010

AbstractBACKGROUND.The authors compared the types of treatments prostate cancer patients received from county hospitals and private providers as part of a statewide public assistance program.METHODS.This was a cohort study of 559 men enrolled in a state‐funded program for low‐income patients known as Improving Access, Counseling, and Treatment for Californians With Prostate Cancer (IMPACT). Multinomial regression was used to compare types of treatments patients received from different providers.RESULTS.Between 2001 and 2006, 315 (56%) participants received treatment from county hospitals and 244 (44%) from private providers. There were no significant between‐group differences with respect to age (P = .22), enrollment year (P = .49), Charlson comorbidity index (P = .47), Gleason sum (P = .33), clinical T stage (P = .36), prostate‐specific antigen (P = .39), or D'Amico risk criteria (P = .45). Participants treated by private providers were more likely than those treated in county hospitals to be white (35% vs 10%, P < .01) and less likely to undergo surgery (29% vs 54%, P < .01). Multinomial regression analyses showed that participants treated by private providers were nearly 2½ times more likely than those treated by public providers to receive radiotherapy (odds ratio [OR], 2.36; 95% confidence interval [CI], 1.37‐4.07) and >4½ times more likely to receive primary androgen deprivation (OR, 4.71; 95% CI, 2.15‐10.36) than surgery.CONCLUSIONS.In this economically disadvantaged cohort, prostate cancer treatments differed significantly between county hospitals and private providers. These data reveal substantial variations in treatment patterns between different types of healthcare institutions that—given the implications for health policy and quality of care—merit further scrutiny. Cancer 2010. © 2010 American Cancer Society.
High‐performance hybrid information service architecture
Authors: Aktas Mehmet S. , Pierce Marlon 
Published: January 2010

AbstractWe introduce a distributed high‐performance Information Service Architecture, which forms a metadata replica hosting system to manage both highly dynamic small‐scale metadata and relatively large static metadata associated with Grid/Web Services. We present an empirical evaluation of the proposed architecture and investigate its practical usefulness. The results demonstrate that the proposed system achieves high performance and fault tolerance with negligible processing overheads. The results also indicate that efficient decentralized hybrid Information Service Architectures can be built by utilizing publish‐subscribe‐based messaging schemes. Copyright © 2010 John Wiley & Sons, Ltd.
Hydrogen Evolution on Single‐Crystal Copper and Silver: A Theoretical Study
Authors: Santos Elizabeth , Pötting Kay , Lundin Angelica , Quaino Paola , Schmickler Wolfgang 
Published: January 2010

AbstractHydrogen evolution on single‐crystal copper and silver is investigated by a combination of density functional theory and a theory developed in our own group. At short times, the reaction rate is determined by the transfer of the first proton to the electrode surface. In accord with experiment, we find for both metals that this reaction proceeds faster on the (111) surfaces than on the (100) ones. The main cause is the lower, that is, more favourable, adsorption energy on the former surfaces. On both silver surfaces, the second step is electrochemical desorption. The same mechanism is likely to operate on copper.
A Promising Approach to the Synthesis of 3D Nanoporous Graphitic Carbon as a Unique Electrocatalyst Support for Methanol Oxidation
Authors: Tiwari Jitendra N. , Tiwari Rajanish N. , Chang Yun‐Min , Lin Kun‐Lin 
Published: January 2010

AbstractA 3D nanoporous graphitic carbon (g‐C) material is synthesized by using an adamantane (C10H16) flame, and utilized to support a Pt50–Ru50 alloy catalyst. The physico‐chemical properties of the Pt50–Ru50/3D nanoporous g‐C electrode are examined by a range of spectroscopy techniques as well as Brunauer–Emmett–Teller surface area analysis. Cyclic voltammetry measurements are used for electrochemical characterization of the Pt50–Ru50/3D nanoporous g‐C electrode. The electrochemical investigations show that the supported Pt50–Ru50 has excellent activity and stability towards methanol electro‐oxidation. Good CO tolerance is also shown, and considered to be due to the presence of Ru nanoparticles. It is proposed that Ru is able to promote the oxidation of strongly adsorbed CO on Pt by supplying an oxygen source: Ru(OH)ad. Moreover, the presence of 3D nanopores in the g‐C support may also contribute to the observed higher current density by virtue of the easy transport of methanol and the oxidation products through these nanopores.
Inadequacies of absolute threshold levels for diagnosing prediabetes
Authors: Bergman Michael 
Published: January 2010

AbstractPrediabetes comprising Impaired Fasting Glucose (IFG) and Impaired Glucose Tolerance (IGT) represents an intermediate stage of altered glucose metabolism between normal glucose levels and type 2 diabetes mellitus and is associated with an increased risk for the development of diabetes and cardiovascular disease. There is considerable evidence that glucose levels lower than those meeting the current definition of prediabetes may also be associated with similar risks particularly in high‐risk individuals. Prediabetes is often unrecognized and therefore constitutes a major public health concern suggesting the need for earlier intervention than is currently recommended. Copyright © 2010 John Wiley & Sons, Ltd.
Unexpectedly high rates of obesity and dysglycemia among villagers in Cameroon
Authors: Napoli Nicola , Mottini Giovanni , Arigliani Michele , Creta Antonio , Giua Renato , Incammisa Antonino , Carotti Simone , Sihom François , Yimagou Isaac , Alombah Richard , Mbanya Jean Claude , Pozzilli Paolo 
Published: January 2010

AbstractOur survey in Cameroon recorded obesity and dysglycemia in inhabitants, which are similar to those reported elsewhere in the region. Typically these metabolic disturbances are attributed to the adoption of a new urban lifestyle including diminished physical activity and an altered (‘Western’) diet. Unexpectedly we found that, like urban populations, our rural population had high rates of metabolic disturbances, despite living in villages and being physically active and consuming traditional diet that is high in plant sources of food and low in meat. From our preliminary study, we raise the possibility that the environmental elements that are driving the pandemic of obesity and diabetes in sub‐Saharan Africa are far more complex than heretofore appreciated. Copyright © 2010 John Wiley & Sons, Ltd.