bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ocular Mpox in a Breastfeeding Healthcare Provider
Authors: Lovett Sara , Griffith Jayne , Lehnertz Nick , Fox Teresa , Siwek Greg , Barnes Aaron M T , Kofman Aaron D , Hufstetler Kaitlin , Greninger Alexander L , Townsend Michael B , Carson William C , Lynfield Ruth , Cash-Goldwasser Shama 
Published: May 2024

Abstract
A healthcare provider unknowingly treated a patient with mpox and subsequently developed ocular mpox without rash. She breastfed during illness; her infant was not infected. This report addresses 3 challenges in mpox management and control: diagnosis in the absence of rash, exposures in healthcare settings, and management of lactating patients.
CVAs in Practice
Authors: Kar Partha , Ziegler Ann-Kathrin , Lacey Sean , Jemmett Thomas , Kassam Karim 
Published: May 2024

Abstract
This chapter expounds on the practical considerations and structure of CVAs and proposes landlord CVAs. Over time, the market developed that CVAs have been utilised for numerous purposes in practices such as restructuring contexts and rationalising lease portfolios. Additionally, CVAs can be used as a tool to implement a commercial compromise arrangement between companies and creditors sans a consensual agreement regardless of the debtor's insolvency. Partial consent can only bind consenting parties instead of shielding dissenting creditors from enforcement actions. Jurisdictions and foreign recognition are considered when invoking a CVA. The chapter also tackles an overview of the CVAs taken by Steinhoff International Holdings NV's affiliates.
Hyperbaric oxygen treatment reveals spatiotemporal OXPHOS plasticity in the porcine heart
Authors: Heidler Juliana , Cabrera-Orefice Alfredo , Wittig Ilka , Heyne Estelle , Tomczak Jan-Niklas , Petersen Bjoern , Henze Dirk , Pohjoismäki Jaakko L O , Szibor Marten 
Published: May 2024

Abstract
Cardiomyocytes meet their high ATP demand almost exclusively by oxidative phosphorylation (OXPHOS). Adequate oxygen supply is an essential prerequisite to keep OXPHOS operational. At least two spatially distinct mitochondrial subpopulations facilitate OXPHOS in cardiomyocytes, i.e. subsarcolemmal (SSM) and interfibrillar mitochondria (IFM). Their intracellular localization below the sarcolemma or buried deep between the sarcomeres suggests different oxygen availability. Here, we studied SSM and IFM isolated from piglet hearts and found significantly lower activities of electron transport chain enzymes and F1FO-ATP synthase in IFM, indicative for compromised energy metabolism. To test the contribution of oxygen availability to this outcome, we ventilated piglets under hyperbaric hyperoxic (HBO) conditions for 240 min. HBO treatment raised OXPHOS enzyme activities in IFM to the level of SSM. Complexome profiling analysis revealed that a high proportion of the F1FO-ATP synthase in the IFM was in a disassembled state prior to the HBO treatment. Upon increased oxygen availability, the enzyme was found to be largely assembled, which may account for the observed increase in OXPHOS complex activities. Although HBO also induced transcription of genes involved in mitochondrial biogenesis, a full proteome analysis revealed only minimal alterations, meaning that HBO-mediated tissue remodeling is an unlikely cause for the observed differences in OXPHOS. We conclude that a previously unrecognized oxygen-regulated mechanism endows cardiac OXPHOS with spatiotemporal plasticity that may underlie the enormous metabolic and contractile adaptability of the heart.
A biospecies-derived genomic DNA hybrid gel electrolyte for electrochemical energy storage
Authors: Mitta Sekhar Babu , Kim Jeonghun , Rana Harpalsinh H , Kokkiligadda Samanth , Lim Yong Taik , Bhang Suk Ho , Park Ho Seok , Um Soong Ho 
Published: May 2024

Abstract
Intrinsic impediments, namely weak mechanical strength, low ionic conductivity, low electrochemical performance, and stability have largely inhibited beyond practical applications of hydrogels in electronic devices and remains as a significant challenge in the scientific world. Here, we report a biospecies-derived genomic DNA hybrid gel electrolyte with many synergistic effects, including robust mechanical properties (mechanical strength and elongation of 6.98 MPa and 997.42%, respectively) and ion migration channels, which consequently demonstrated high ionic conductivity (73.27 mS/cm) and superior electrochemical stability (1.64 V). Notably, when applied to a supercapacitor the hybrid gel-based devices exhibit a specific capacitance of 425 F/g. Furthermore, it maintained rapid charging/discharging with a capacitance retention rate of 93.8% after ∼200,000 cycles while exhibiting a maximum energy density of 35.07 Wh/kg and a maximum power density of 193.9 kW/kg. This represents the best value among the current supercapacitors and can be immediately applied to minicars, solar cells, and LED lightning. The widespread use of DNA gel electrolytes will revolutionize human efforts to industrialize high-performance green energy.
American Federalism: A Blessing and a Curse for Transgender Rights
Authors: Taylor Jami , Flores Andrew , Haider-Markel Donald , Lewis Daniel , Miller Patrick 
Published: May 2024

Abstract
The development of transgender rights in the United States has been hobbled by a patchwork of inconsistent state laws. The irregularity is a function of the political opportunity structure in the United States, which is defined by a sharp partisan divide and by the federal system’s division of power. National policymaking on transgender rights has stalled in Congress. Executive branch policymaking is often subject to challenge in the federal courts, and different administrations have varied in their approaches. In addition, the Supreme Court’s decision in Bostock narrowly advanced transgender rights in employment law but also invited challenges in other areas. With inaction and inconsistency at the national level, states are using their reserved powers in the federal system to diverge along the partisan divide. Republican-controlled states are enacting repressive measures, while Democratic-controlled states have done the opposite. For transgender people, their rights are increasingly dependent on which state they are in.
“You Can’t Just Give People Food”: Whiteness in Practice at an Evangelical Food Pantry
Authors: McNeely Andrew 
Published: May 2024

Abstract
Whiteness continues to be a focus of scholarly research particularly as it informs understandings of white evangelical religious structures, organizations, and practices. This study draws on 34 months of ethnographic study to present a case study of an evangelical food pantry in central Texas and analyzes the policies, roles, and norms of the volunteers. The findings document examples of white, conservative, evangelical religious practices that promote the meaning–making and worldviews of evangelical volunteers while erasing and disempowering the recipients. Taken together, these findings add to our understanding of whiteness, which is already evidenced at the structural level by documenting examples of everyday practices in public spaces that promote racialized hierarchies.
The pharynx of the iconic stem-group chondrichthyan Acanthodes Agassiz, 1833 revisited with micro-computed tomography
Authors: Dearden Richard P , Herrel Anthony , Pradel Alan 
Published: May 2024

Abstract
Acanthodes has long been the primary source of information on the pharyngeal skeleton of ‘acanthodians’. Because of this its anatomy has played a disproportionate role in attempts to understand the evolution of the jawed vertebrate pharynx and the clade as a whole. However, the anatomy of the pharynx of Acanthodes, now understood to be a stem-group chondrichthyan, remains poorly characterized and subject to several competing interpretations. We used computed tomography to image the articulated pharyngeal skeletons of three specimens of Acanthodes confusus from Lebach, Germany. Acanthodes has a mélange of osteichthyan-like and chondrichthyan-like morphologies in its pharyngeal skeleton. Like many other chondrichthyans, Acanthodes lacked hypohyals, and had four pairs of posteriorly oriented pharyngobranchials. Like osteichthyans, Acanthodes possessed an interhyal, but lacked the separate infra- and supra-pharyngobranchial elements present in osteichthyans and the crown-chondrichthyan Ozarcus. Using these new data we built and animated a digital 3D model of the pharyngeal endoskeleton in Acanthodes, showing that the jaws could have swung outwards during the opening cycle, increasing the anteriorly facing area of the gape for suspension feeding. These new data provide a more definitive picture of the anatomy of a taxon that has long been of great significance in early vertebrate palaeontology.
Impact of Socioeconomic Factors on Time to Surgery for Distal Radius Fractures
Authors: Marxen Troy , Stewart Chris , Razavi Amir , Payne Sam , Ghareeb Paul 
Published: May 2024

Background:
Delay in care secondary to socioeconomic status (SES) and demographic factors represents an area for potential improvement. Reducing time to surgery in distal radius fracture (DRF) fixation may improve outcomes while reducing cost. The purpose of this study is to investigate the effect of SES on time to surgery in our study population.

Methods:
Patients undergoing outpatient DRF surgery within an academic healthcare system during a 4-year period were reviewed. Time to surgery and demographic factors were analyzed. The US Census Bureau was used to determine median household income (MHI) for a patient’s ZIP code; patients were stratified into three groups based on MHI.

Results:
A total of 413 patients met inclusion criteria. SES (14.7 d in the low-SES group, 14.0 d in the mid-SES group, and 11.1 d in the high-SES group, P = 0.00063), insurance (11.7 d for insured versus 16.3 d for Medicaid/uninsured, P < 0.0001), race (non-White group: 15.2 d versus White group: 10.9 d, P < 0.0001), and treatment facility (16.2 d at county hospital versus 10.9 d at university hospital, P < 0.0001) were associated with time to surgery in univariate analysis. Multivariate analysis found that only treatment facility was associated with time to surgery.

Conclusions:
Non-White, uninsured/Medicaid individuals residing in low-SES areas may be more likely to receive care at a safety-net facility and are at greatest risk for delay in time to surgery. Measures aimed to reduce barriers to care, increase healthcare coverage, and improve patient education should be initiated to mitigate these disparities.
Implementation of anterior segment ophthalmic telemedicine
Authors: Armstrong Grayson W. , Liebman Daniel L. , Ashourizadeh Helia 
Published: May 2024

Purpose of review
The growing push to integrate telemedicine into ophthalmic practices requires physicians to have a thorough understanding of ophthalmic telemedicine's applications, limitations, and recent advances in order to provide well tolerated and appropriate clinical care. This review aims to provide an overview of recent advancements in the use of ophthalmic telemedicine for anterior segment eye examinations.

Recent findings
Virtual care for anterior segment evaluation relies on appropriate technology, novel workflows, and appropriate clinical case selection. Recent advances, particularly in the wake of the COVID-19 pandemic, have highlighted the utility of home-based assessments for visual acuity, external evaluation, tonometry, and refraction. Additionally, innovative workflows incorporating office-based testing into virtual care, termed ‘hybrid telemedicine’, enable high-quality ophthalmic testing to inform clinical decision-making.

Summary
Novel digital tools and workflows enable high-quality anterior segment evaluation and management for select ophthalmic concerns. This review highlights the clinical tools and workflows necessary to enable anterior segment telehealth.
Effectiveness of a Patient Safety Incident Disclosure Education Program: A Quasi-Experimental Study
Authors: KIM Mi Young , KIM Yujeong 
Published: May 2024

ABSTRACT

Background
The accurate disclosure of patient safety incidents is necessary to minimize patient safety incidents and medical disputes. As prospective healthcare providers, nursing students need to possess the ability to disclose patient safety incidents.

Purpose
This study was designed to investigate the effect of a patient safety incident disclosure education program for undergraduate nursing students on participants' knowledge and perception of disclosure of these incidents, attitudes toward patient safety, and self-efficacy regarding disclosure of these incidents.

Methods
A quasi-experimental study with a nonequivalent pretest–posttest design was conducted on fourth-year undergraduate nursing students recruited between September 6 and October 22, 2021, through convenience sampling from two universities in South Korea. The experimental group (n = 25) received the education program. The control group (n = 25) received educational materials on the disclosure of patient safety incidents only. Knowledge and perceptions of patient safety incident disclosure, attitudes toward patient safety, and self-efficacy regarding incident disclosure were measured. Data were analyzed using descriptive analysis, t test, χ2 test, Fisher's exact test, Mann–Whitney U test, Wilcoxon signed-rank test, and ranked analysis of covariance.

Results
Posttest results revealed knowledge (p < .001), perceptions (p = .031), and self-efficacy (p < .001) with regard to the disclosure of patient safety incidents were all significantly higher in the experimental group than in the control group. Posttest attitudes toward patient safety were not significantly different between the two groups (p = .908).

Conclusions/Implications for Practice
The patient safety incident disclosure education program effectively enhances the knowledge, perception, and self-efficacy of nursing students with regard to safety incidents. The findings may be used to improve training and educational programs in nursing colleges and hospitals to improve the knowledge, perception, and self-efficacy of nursing students with regard to disclosing patient safety incidents in clinical settings.
Development of a Novel Evidence-Based Practice-Specific Competency for Doctor of Physical Therapy Students in Clinical Education: A Modified Delphi Approach
Authors: Haladay Douglas , Morris Zoe , Tilson Julie , Fitzgerald Caitlin , Applebaum Donna , Flom-Meland Cindy , DeWaay Deborah , Manal Tara Jo , Gravano Tamara , Anderson Stephanie , Miro Rebecca , Russ David , Klein Aimee 
Published: May 2024

Introduction.
Evidence-based practice (EBP) results in high-quality care and decreases unwarranted variation in practice.

Review of the Literature.
Few performance criteria related to EBP are included in physical therapy clinical education (CE) performance measures, despite EBP requirements in Doctor of Physical Therapy education. The purpose of this study was to develop EBP-specific competencies that may be used for Doctor of Physical Therapy students for use throughout CE.

Subjects.
Thirteen subject matter experts (SME) participated in this study.

Methods.
Subject matter experts were asked to rank each core EBP competency, from a previously described framework, using a 3-point Likert scale, which included “Not Essential,” “Essential,” and “Not Sure.” A consensus of 70% or greater for the “Essential” rating advanced the competency to the final Delphi round, whereas a consensus of 70% or greater for the “Not Essential” rating was required for competency elimination. Subject matter experts voted to either “Accept” or “Modify” the competencies that had reached the inclusion consensus threshold. All competencies that reached consensus for inclusion after all 3 rounds were included in the final EBP Domain of Competence.

Results.
Consensus was achieved in round one for 38% (n = 26) of items. In round 2, a consensus was achieved for 20% (n = 8) of items. Of the items remaining after rounds 1 and 2, 6 overarching competencies were identified, and all remaining items served as descriptions and specifications in the final EBP Domain of Competence.

Discussion and Conclusions.
The 6 competencies developed from this study constitute the EBP Domain of Competence and may be used throughout CE to assess students' EBP competency in clinical practice.
Protease activated receptor-4: ready to be part of the antithrombosis spectrum
Authors: Andrianova Izabella , Kowalczyk Mia , Denorme Frederik 
Published: May 2024

Purpose of review
Cardiovascular disease is a major cause of death worldwide. Platelets play a key role in this pathological process. The serine protease thrombin is a critical regulator of platelet reactivity through protease activated receptors-1 (PAR1) and PAR4. Since targeting PAR4 comes with a low chance for bleeding, strategies blocking PAR4 function have great antithrombotic potential. Here, we reviewed the literature on platelet PAR4 with a particular focus on its role in thromboinflammation.

Recent findings
Functional PAR4 variants are associated with reduced venous thrombosis risk (rs2227376) and increased risk for ischemic stroke (rs773902). Recent advances have allowed for the creation of humanized mouse lines in which human PAR4 is express instead of murine PAR4. This has led to a better understanding of the discrepancies between human and murine PAR4. It also made it possible to introduce single nucleotide polymorphisms (SNPs) in mice allowing to directly test the in vivo functional effects of a specific SNP and to develop in vivo models to study mechanistic and pharmacologic alterations induced by a SNP.

Summary
PAR4 plays an important role in cardiovascular diseases including stroke, myocardial infarction and atherosclerosis. Targeting PAR4 hold great potential as a safe antithrombotic strategy.
Patient Surveillance Adherence After Treatment for Endometrial Cancer
Authors: Zhang Naixin , Marshall Lila , Thappa Sarah , Morell Alexandra , Samborski Alexandra , Moore Richard , Wilbur MaryAnn 
Published: May 2024

BACKGROUND:
To assess factors that may affect patients' adherence to recommended surveillance after treatment for endometrial cancer.

METHODS:
We performed a retrospective study of all patients undergoing primary treatment for endometrial cancer from January 1, 2010, to December 30, 2017, at a tertiary referral center. Patients were included for analysis if there was sufficient information in the electronic medical records. Patient demographic information, cancer characteristics, and surveillance adherence data were collected. The median inflation-adjusted income was calculated from the patients' ZIP codes and U.S. Census data. The primary outcome assessed was adherence to surveillance, defined as two or more visits per 12 months in individuals at low risk and four or more visits per 12 months in individuals at high risk, consistent with recommended guidelines.

RESULTS:
During the study period, 870 patients were included for analysis. The mean age at diagnosis and body mass index (BMI) of the entire cohort were 63.4 years and 35.8, respectively. Overall, 761 patients (87.5%) were adherent to the recommended surveillance guidelines. Patients who were not adherent to recommended surveillance lived significantly farther from the cancer center (39.2 miles vs 20.7 miles, P=.026) and had a significantly lower median inflation-adjusted income ($74,015 vs $80,435, P=.027).

CONCLUSION:
Increased distance to a tertiary care center and lower median income were significantly associated with decreased adherence to recommended surveillance guidelines. This is consistent with current literature on increased distance traveled as a proxy for worse survival in gynecologic malignancies, as well as worse endometrial cancer outcomes in patients of lower socioeconomic status. This highlights an area of disparity that needs improvement and warrants further investigation.
EFFICACY OF A SEPSIS CLINICAL DECISION SUPPORT SYSTEM IN IDENTIFYING PATIENTS WITH SEPSIS IN THE EMERGENCY DEPARTMENT
Authors: Hou Yueh-Tseng , Wu Meng-Yu , Chen Yu-Long , Liu Tzu-Hung , Cheng Ruei-Ting , Hsu Pei-Lan , Chao An-Kuo , Huang Ching-Chieh , Cheng Fei-Wen , Lai Po-Lin , Wu I-Feng , Yiang Giou-Teng 
Published: May 2024

ABSTRACT

Background: Early prediction of sepsis onset is crucial for reducing mortality and the overall cost burden of sepsis treatment. Currently, few effective and accurate prediction tools are available for sepsis. Hence, in this study, we developed an effective sepsis clinical decision support system (S-CDSS) to assist emergency physicians to predict sepsis. Methods: This study included patients who had visited the emergency department (ED) of Taipei Tzu Chi Hospital, Taiwan, between January 1, 2020, and June 31, 2022. The patients were divided into a derivation cohort (n = 70,758) and a validation cohort (n = 27,545). The derivation cohort was subjected to 6-fold stratified cross-validation, reserving 20% of the data (n = 11,793) for model testing. The primary study outcome was a sepsis prediction (International Classification of Diseases, Tenth Revision, Clinical Modification) before discharge from the ED. The S-CDSS incorporated the LightGBM algorithm to ensure timely and accurate prediction of sepsis. The validation cohort was subjected to multivariate logistic regression to identify the associations of S-CDSS-based high- and medium-risk alerts with clinical outcomes in the overall patient cohort. For each clinical outcome in high- and medium-risk patients, we calculated the sensitivity, specificity, positive and negative predictive values, positive and negative likelihood ratios, and accuracy of S-CDSS-based predictions. Results: The S-CDSS was integrated into our hospital information system. The system featured three risk warning labels (red, yellow, and white, indicating high, medium, and low risks, respectively) to alert emergency physicians. The sensitivity and specificity of the S-CDSS in the derivation cohort were 86.9% and 92.5%, respectively. In the validation cohort, high- and medium-risk alerts were significantly associated with all clinical outcomes, exhibiting high prediction specificity for intubation, general ward admission, intensive care unit admission, ED mortality, and in-hospital mortality (93.29%, 97.32%, 94.03%, 93.04%, and 93.97%, respectively). Conclusion: Our findings suggest that the S-CDSS can effectively identify patients with suspected sepsis in the ED. Furthermore, S-CDSS-based predictions appear to be strongly associated with clinical outcomes in patients with sepsis.