bluuebunny/crossref_metadata_2025_split huggingface dataset:
Transplantation of side population cells restores the function of damaged exocrine glands through clusterin
Authors: Mishima Kenji , Inoue Hiroko , Nishiyama Tatsuaki , Mabuchi Yo , Amano Yusuke , Ide Fumio , Matsui Makoto , Yamada Hiroyuki , Yamamoto Gou , Tanaka Junichi , Yasuhara Rika , Sakurai Takashi , Lee Masaichi-Chang-il , Chiba Kan , Sumimoto Hidetoshi , Kawakami Yutaka , Matsuzaki Yumi , Tsubota Kazuo , Saito Ichiro 
Published: July 2012

Abstract
Stem cell-based therapy has been proposed as a promising strategy for regenerating tissues lost through incurable diseases. Side population (SP) cells have been identified as putative stem cells in various organs. To examine therapeutic potential of SP cells in hypofunction of exocrine glands, SP cells isolated from mouse exocrine glands, namely, lacrimal and salivary glands, were transplanted into mice with irradiation-induced hypofunction of the respective glands. The secretions from both glands in the recipient mice were restored within 2 months of transplantation, although the transplanted cells were only sparsely distributed and produced no outgrowths. Consistent with this, most SP cells were shown to be CD31-positive endothelial-like cells. In addition, we clarified that endothelial cell-derived clusterin, a secretory protein, was an essential factor for SP cell-mediated recovery of the hypofunctioning glands because SP cells isolated from salivary glands of clusterin-deficient mice had no therapeutic potential, whereas lentiviral transduction of clusterin restored the hypofunction. In vitro and in vivo studies showed that clusterin had an ability to directly inhibit oxidative stress and oxidative stress-induced cell damage. Thus, endothelial cell-derived clusterin possibly inhibit oxidative stress-induced hypofunction of these glands.
Surgical Outcomes After Resection of Both Hepatic and Pulmonary Metastases From Colorectal Cancer
Authors: Sakamoto Yasuo , Sakaguchi Yoshihisa , Oki Eiji , Minami Kazuhito , Toh Yasushi , Okamura Takeshi 
Published: July 2012

AbstractBackgroundThe efficacy and the indications of resection of synchronous or metachronous hepatic and pulmonary metastases from colorectal cancer (CRC) are controversial. This study retrospectively reviewed the cases of CRC patients who underwent both liver and lung resection to define the appropriate indications for surgical resection in patients with hepatic and pulmonary metastases.MethodsA total of 39 patients with both hepatic and pulmonary metastases from CRC underwent both liver and lung resection from January 1987 to December 2009. The relapse‐free survival (RFS) and overall survival (OS) from the resection for the first metastasis were evaluated by a Kaplan–Meyer analysis. Prognostic factors were analyzed using the log‐rank test and a Cox proportional hazards model.ResultsThe median RFS and the 5‐year RFS rate of all patients were 12 months and 2.6 %, respectively. The median survival time (MST) and 5‐year OS rate of all patients were 66 months and 48.3 %, respectively. The MST of the patients with a long (>1 year) disease‐free interval (DFI) could not be calculated, but their 5‐year OS rate was 73.7 %. In contrast, the MST and 5‐year OS rate of the patients with a short (<1 year) DFI were 29 months and 37.5 %, respectively. The short DFI was the only prognostic factor in the multivariate analysis.ConclusionsAggressive surgical resection of both hepatic and pulmonary metastases from CRC should be undertaken in selective patients, including those with a long DFI.
trans‐10,cis‐12 Conjugated Linoleic Acid Enhances Endurance Capacity by Increasing Fatty Acid Oxidation and Reducing Glycogen Utilization in Mice
Authors: Kim Jun Ho , Kim Jonggun , Park Yeonhwa 
Published: July 2012

AbstractThe supplementation of conjugated linoleic acid (CLA) has been shown to improve endurance by enhancing fat oxidation during exercise in rodents and humans. This study was designed to investigate the isomer‐specific effects of CLA on endurance capacity and energy metabolism in mice during exercise. Male 129Sv/J mice were divided into three dietary groups and fed treatment diet for 6 weeks; control, 0.5 % cis‐9,trans‐11 (c9,t11) CLA, or 0.5 % trans‐10,cis‐12 (t10,c12) CLA. Dietary t10,c12 CLA induced a significant increase in maximum running time and distance until exhaustion with a dramatic reduction of total adipose depots compared to a control group, but there were no significant changes in endurance with the c9,t11 CLA treatment. Serum triacylglycerol and non‐esterified fatty acid concentrations were significantly lower in the t10,c12 fed mice after exercise compared to control and the c9,t11 CLA fed‐animals. Glycogen contents in livers of the t10,c12 fed‐mice were higher than those in control mice, concomitant with reduction of serum l‐lactate level. There were no differences in non‐exercise physical activity among all treatment groups. In addition, the mRNA expression levels of carnitine palmitoyl transferase 1β, uncoupling protein 2 and peroxisome proliferator‐activated receptor δ (PPARδ) in skeletal muscle during exercise were significantly up‐regulated by the t10,c12 CLA but not the c9,t11 CLA. These results suggest that the t10,c12 CLA is responsible for improving endurance exercise capacity by promoting fat oxidation with a reduction of the consumption of stored liver glycogen, potentially mediated via PPARδ dependent mechanisms.
Hétérosexualités, corps et care : l’exemple des hommes d’Ardecom
Authors: Desjeux C. 
Published: July 2012

RésuméArdecom (1979–1986), une association ayant milité pour la contraception hormonale masculine, se met en place en France suite au mouvement féministe des années 1970. En analysant le vécu de ces hommes qui ont expérimenté une contraception hormonale, il est proposé de voir comment ils ont pu proposer un autre modèle « hétérosexuel hybride ». Cet article s’appuie sur des entretiens et la presse des années 1980 dans laquelle certains d’entre eux témoignent.
Variations in cephalic vein venography for device implantation–Relationship to success rate of lead implantation
Authors: Tokano Takashi , Nakazato Yuji , Shiozawa Tomoyuki , Konishi Hirokazu , Hiki Masaru , Kato Yoshiteru , Komatsu Sayaka , Yamase Miki , Komatsu Kaoru , Hayashi Hidemori , Sekita Gaku , Suwa Satoru , Bito Fumiyasu , Kizu Kyoko , Sumiyoshi Masataka , Daida Hiroyuki 
Published: July 2012

AbstractIntroductionLead implantation using the cephalic vein (CV) cutdown technique has been well established, but is not always expected to achieve high success rates. We studied the relationship between preoperative CV venography and the success rate of lead implantation.MethodsTwo hundred and twenty one CV venographies were performed in 205 patients (mean age 75 years, 113 males). Leads were inserted via the CV cutdown technique with a guidewire and sheath. Variations in CV venography included usage of the right and left CVs. The success rate of lead implantation was studied.ResultsNo major kink was observed in 71% of the right CV cases and 43% of the left CV cases. Leads were successfully implanted in over 90% of these patients. A major kink in the CV was found in 15% of the right CV cases and 34% of the left CV cases and successful lead implantation was around 80% in this population. The overall success rate tended to be higher for the right side (83%) than for the left side (71%).ConclusionSevere kinks or variations in the CV that hinder lead manipulation were less frequent in the right CV. Therefore, a higher success rate of lead implantation by the cutdown technique is expected for the right CV.
Current strategies of anticoagulation therapy for patients with non‐valvular atrial fibrillation
Authors: Yasaka Masahiro 
Published: July 2012

AbstractCardioembolic stroke accounts for 20–30% of acute brain infarctions in Japan. This condition is often severe and has poor outcomes. Non‐valvular atrial fibrillation (NVAF) is the most common cardiac source of emboli in cardioembolic stroke. Anticoagulants are recommended for preventing stroke in patients with NVAF, and these patients were usually treated with warfarin. However, the use of warfarin has many limitations. Approximately half of the patients with NVAF, who show indications for warfarin treatment, are treated with warfarin. Bleeding complications, including intracranial hemorrhages, are common during warfarin treatment; this is a huge concern of warfarin treatment. Warfarin‐associated intracranial hemorrhage is often severe and devastating. Several novel anticoagulants that can overcome the limitations of warfarin have been introduced in the market or are under development. In this review, we discuss the pharmacological properties of novel anticoagulants and current strategies of anticoagulation therapy for preventing stroke in patients with NVAF.
Factor structure, reliability, and validity of the Chinese version of the School Bullying Experience Questionnaire
Authors: Yen Cheng‐Fang , Kim Young‐Shin , Tang Tze‐Chun , Wu Yu‐Yu , Cheng Chung‐Ping 
Published: July 2012

AbstractThe aims of this study were to examine the factor structure, internal consistency, 1‐month test–retest reliability, and congruent validity of the Chinese version of the School Bullying Experience Questionnaire (C‐SBEQ). Study 1, in which 5751 Taiwanese adolescents in Southern Taiwan participated, examined the adequacy of the original four‐factor structure of the C‐SBEQ using confirmatory factor analysis (CFA) and internal‐consistency reliability using Cronbach α. Study 2, in which 108 adolescents in Southern Taiwan participated, examined the 1‐month test–retest reliability using intraclass correlation coefficients (ICCs). We examined the congruent validity of the C‐SBEQ by examining the consistency between self‐reported and teacher‐ and classmate‐nominated experiences of bullying involvement in Study 2. The results of CFA supported the four‐factor structure of the C‐SBEQ in Taiwanese adolescents. The test–retest and internal reliability values of all subscales of the C‐SBEQ were at acceptable to satisfactory levels. Nominated adolescents had significantly higher self‐reported scores on three C‐SBEQ subscales than non‐nominated ones, and the levels of agreement between self‐reported and nominated victims were moderate. The results of this study indicate that the C‐SBEQ is appropriate for assessing bullying experiences in Taiwanese adolescents.
Plasticizer incident and its health effects in Taiwan
Authors: Li Jih‐Heng , Ko Ying‐Chin 
Published: July 2012

AbstractThe May 23, 2011, plasticizer incident was one of the most serious food safety issues that ever occurred in Taiwan. Most, if not all, plasticizer‐contaminated food items were due to malicious replacement of palm oil with phthalate plasticizer(s) in the cloudy‐agent formulas by two upstream manufacturers. The incumbent agencies in Taiwan took necessary actions to minimize the harm caused by the incident and to ease the panic of the general public. In this paper, the incident was briefly reviewed and the situations of phthalate exposure in general public and pregnant women were assessed. Subsequently, the associations between phthalates exposure and the adverse health effects, such as shortened anogenital distance in baby boys, premature thelarche in young girls, endometriosis, adenomyosis, and leiomyoma in women, and decreased semen quality in men, were discussed. Food safety issue has become a worldwide concern and early detection of potential new toxicants in the foods is indispensable. Therefore, it is imperative to establish an international network for early warning or sentinel on food safety.
The impact of a dam on the helminth fauna and health of a neotropical fish species Salminus brasiliensis (Cuvier 1816) from the upper Paraná River, Brazil
Authors: Karling L.C. , Isaac A. , Affonso I.P. , Takemoto R.M. , Pavanelli G.C. 
Published: July 2012

AbstractThe aim of the present study was to detect changes in the structure of the helminth parasite infracommunities in Salminus brasiliensis (Cuvier 1816) from the floodplain of the upper Paraná River after construction of the Porto Primavera Hydroelectric Plant. A total of 126 fish in the period before the dam's construction and 56 specimens 10 years after this event were analysed. Three species of parasites were collected before the construction of the dam: Prosthenhysteraobesa Diesing, 1850 (Digenea), Cladocystis intestinalis Vaz, 1932 (Digenea) and Monticellia coryphicephala Monticelli, 1892 (Cestoda), and one nematode species in the larval stage, whose identification was not possible. After dam construction, the following helminth parasites were found: C. intestinalis, M. coryphicephala, Octospiniferoides incognita, Contracaecum spp. larvae and Contracaecum sp. type 2 larvae Moravec, Kohn & Fernandes 1993. The diversity of helminth parasites measured by the Brillouin diversity index (HB) differed significantly between the pre- and post-dam periods (mean HB = 0.069 and HB = 0.2, respectively; P= 0.0479; Mann–Whitney U test). The parasite community of S. brasiliensis before the construction of the dam showed concentration of dominance (C) of P. obesa (C = 0.38), while there was no concentration of dominance of any species of parasite (C = 0.22) after the dam's construction. Before the Porto Primavera dam the relative condition factor of fish was 1.0; after the dam's construction it was 0.93 (P < 0.0001; Mann–Whitney U test). This study records the disappearance of the species P. obesa and suggests that there has been local extinction of this parasite. The results show that the anthropic influence on natural systems is interfering with the welfare and health of S. brasiliensis, reflected by its fauna of helminth parasites.
F-actin accumulates in the vulva of female Strongyloides venezuelensis
Authors: Silva C.V. , Gonçalves A.L.R. , Cruz L. , Cruz M.C. , Ueta M.T. , Costa-Cruz J.M. 
Published: July 2012

AbstractLittle is known about the actin cytoskeleton architecture in female Strongyloides venezuelensis and thus to investigate the distribution and concentration of actin, female worms were labelled with phalloidin-rhodamine and visualized under confocal microscopy. Our results demonstrate that filamentous actin accumulates in the vulva and the concentration of F-actin at this site suggests its important role, especially during oviposition, in the life cycle of S. venezuelensis.
Patients' beliefs about the causes, persistence and control of psychotic experiences predict take-up of effective cognitive behaviour therapy for psychosis
Authors: Freeman D. , Dunn G. , Garety P. , Weinman J. , Kuipers E. , Fowler D. , Jolley S. , Bebbington P. 
Published: July 2012

BackgroundThere is evidence that patients with schizophrenia benefit from standard cognitive behaviour therapy (CBT) only if active techniques are used (‘full therapy’). By contrast, attending sessions but not proceeding beyond engagement and assessment strategies (‘partial therapy’), or simply not attending sessions (‘no therapy’), is not associated with better outcomes. The factors leading to full therapy are unknown. We hypothesized that patients' initial ideas about the nature and extent of their problems would predict use of CBT. A match between patients' views of their problems and the principles underlying treatment would lead to better outcomes.MethodNinety-two patients with a recent relapse of psychosis completed the Illness Perception Questionnaire (IPQ) before receiving CBT. We examined whether their illness perceptions predicted the take-up of therapy.ResultsPatients who did not attend sessions believed their problems would not last as long as those who attended them. Those who attended sessions but did not proceed to full therapy had a lower sense of control over their problems and a more biological view of their causes. Patients who took up full therapy were more likely to attribute the cause of their problems to their personality and state of mind. The take-up of therapy was predicted neither by levels of psychiatric symptoms nor by insight.ConclusionsPeople with psychosis who have psychologically orientated views of their problems, including the potential to gain control over them, may be more likely to engage fully and do well with standard CBT for psychosis, irrespective of the severity of their problems.
Differential functional connectivity within an emotion regulation neural network among individuals resilient and susceptible to the depressogenic effects of early life stress
Authors: Cisler J. M. , James G. A. , Tripathi S. , Mletzko T. , Heim C. , Hu X. P. , Mayberg H. S. , Nemeroff C. B. , Kilts C. D. 
Published: July 2012

BackgroundEarly life stress (ELS) is a significant risk factor for depression. The effects of ELS exposure on neural network organization have not been differentiated from the effect of depression. Furthermore, many individuals exposed to ELS do not develop depression, yet the network organization patterns differentiating resiliency versus susceptibility to the depressogenic effects of ELS are not clear.MethodWomen aged 18–44 years with either a history of ELS and no history of depression (n = 7), a history of ELS and current or past depression (n = 19), or a history of neither ELS nor depression (n = 12) underwent a resting-state 3-T functional magnetic resonance imaging (fMRI) scan. An emotion regulation brain network consisting of 21 nodes was described using graph analyses and compared between groups.ResultsGroup differences in network topology involved decreased global connectivity and hub-like properties for the right ventrolateral prefrontal cortex (vlPFC) and decreased local network connectivity for the dorsal anterior cingulate cortex (dACC) among resilient individuals. Decreased local connectivity and increased hub-like properties of the left amygdala, decreased hub-like properties of the dACC and decreased local connectivity of the left vlPFC were observed among susceptible individuals. Regression analyses suggested that the severity of ELS (measured by self-report) correlated negatively with global connectivity and hub-like qualities for the left dorsolateral PFC (dlPFC).ConclusionsThese preliminary results suggest functional neural connectivity patterns specific to ELS exposure and resiliency versus susceptibility to the depressogenic effects of ELS exposure.
‘Active ageing’: from empty rhetoric to effective policy tool
Authors: BOUDINY KIM 
Published: July 2012

ABSTRACT‘Active ageing’ is a topic of increasing attention in scientific and policy discussions on ageing, yet there is no consensus on its actual meaning. The current paper proposes a detailed classification of various definitions that have been used since its introduction. These definitions are subjected to critical investigation, and subtle differences with regard to such terms as ‘healthy ageing’ and ‘productive ageing’ are clarified. Bearing the hazards of previous definitions in mind, a comprehensive strategy is initiated. Given that earlier definitions have tended to exclude frail older adults, this strategy pays particular attention to the translation of the active-ageing concept to situations of dependency by centring on three key principles: fostering adaptability, supporting the maintenance of emotionally close relationships and removing structural barriers related to age or dependency.
Finally tagless observable recursion for an abstract grammar model
Authors: DEVRIESE DOMINIQUE , PIESSENS FRANK 
Published: July 2012

AbstractWe define a finally tagless, shallow embedding of a typed grammar language. In order to avoid the limitations of traditional parser combinator libraries (no bottom-up parsing, no full grammar analysis or transformation), we require object-language recursion to be observable in the meta-language. Since existing proposals for recursive constructs are not fully satisfactory, we propose new finally tagless primitive recursive constructs to solve the problem. To do this in a well-typed way, we require considerable infrastructure, for which we reuse techniques from the multirec generic programming library. Our infrastructure allows a precise model of the complex interaction between a grammar, a parsing algorithm and a set of semantic actions. On the flip side, our approach requires the grammar author to provide a type- and value-level encoding of the grammar's domain and we can provide only a limited form of constructs likemany. We demonstrate five meta-language grammar algorithms exploiting our model, including a grammar pretty-printer, a reachability analysis, a translation of quantified recursive constructs to the standard one and an implementation of the left-corner grammar transform. The work we present forms the basis of thegrammar-combinatorsparsing library1, which is the first to work with a precise, shallow model of abstract context-free grammars in a classical (not dependently typed) functional language and which supports a wide range of grammar manipulation primitives. From a more general point of view, our work shows a solution to the well-studied problem of observable sharing in shallowly embedded domain-specific languages and specifically in finally tagless domain-specific languages.
A Graph Polynomial for Independent Sets of Bipartite Graphs
Authors: GE Q. , ŠTEFANKOVIČ D. 
Published: July 2012

We introduce a new graph polynomial that encodes interesting properties of graphs, for example, the number of matchings, the number of perfect matchings, and, for bipartite graphs, the number of independent sets (#BIS).We analyse the complexity of exact evaluation of the polynomial at rational points and show a dichotomy result: for most points exact evaluation is #P-hard (assuming the generalized Riemann hypothesis) and for the rest of the points exact evaluation is trivial.
Maintenance of changes in food intake and motivation for healthy eating among Norwegian-Pakistani women participating in a culturally adapted intervention
Authors: Helland-Kigen Kaja Marie , Råberg Kjøllesdal Marte Karoline , Hjellset Victoria Telle , Bjørge Benedikte , Holmboe-Ottesen Gerd , Wandel Margareta 
Published: July 2012

AbstractObjectiveTo investigate maintenance of changes in food intake and motivation for healthy eating at follow-up 2 data collection after a lifestyle intervention among Pakistani immigrant women.DesignA culturally adapted lifestyle intervention, aiming at reducing the risk of type 2 diabetes mellitus. Data collection including FFQ and questions on intentions to change dietary behaviour was completed at baseline, right after the 7 ± 1 month intervention (follow-up 1) and 2–3 years after baseline (follow-up 2).SettingOslo, Norway.SubjectsPakistani women (n 198), aged 25–60 years, randomized into control and intervention groups.ResultsFrom follow-up 1 to follow-up 2 there was a shift from action to maintenance stages for intention to reduce fat intake (P < 0·001), change type of fat (P = 0·001), increase vegetable intake (P < 0·001) and reduce sugar intake (P = 0·003) in the intervention group. The reduction in intakes of soft drinks with sugar, fruit drinks with sugar and red meats, and the increase in intakes of vegetables and fish from baseline to follow-up 1 were maintained (significant change from baseline) at follow-up 2 in the intervention group. The intake of vegetables was higher (P = 0·019) and the intake of fruit drinks with sugar lower (P = 0·023) in the intervention group compared with the control group at follow-up 2.ConclusionsThe culturally adapted intervention had the potential of affecting intentions to change food behaviour among Pakistani immigrant women long after completion of the intervention and also of leading to long-term maintenance of beneficial changes in diet.