bluuebunny/crossref_metadata_2025_split huggingface dataset:
Parental depression and child outcomes – is marital conflict the missing link?
Authors: Hanington L. , Heron J. , Stein A. , Ramchandani P. 
Published: July 2011

AbstractBackground Both maternal and paternal depression during the perinatal period are associated with adverse effects on child outcomes. Attention has started to focus on the mechanisms mediating these relationships. Marital conflict may play a role in this context.Methods In a large cohort study, the Avon Longitudinal Study of Parents and Children (n= 14 541 pregnancies), we aimed to (i) investigate the relative influences of parental postnatal depression and marital conflict on child outcomes and to attempt to determine the pathway(s) of risk; (ii) investigate the impact of two types of antenatal stress (parental depression and marital conflict) on child outcomes; and (iii) determine the relative contributions of antenatal and postnatal risk. Parents completed the Edinburgh Postnatal Depression Scale and a marital conflict scale during the second trimester and at 8 months postnatally. Child outcomes were assessed at 42 months using the Rutter revised pre‐school scales.Results Marital conflict partially mediated the relationship between postnatal depression in both mothers and fathers and child outcomes, and acted as an independent risk for adverse outcomes. Parental depression (maternal and paternal) and marital conflict in the antenatal period were both associated with adverse effects which persisted even when postnatal stresses were taken into account.Conclusions These findings, if replicated, suggest that screening and intervention programmes targeted at parental depression and marital problems should be considered antenatally, as well as postnatally.
Autoimmune neutropenia in children: analysis of 116 cases
Authors: Audrain Marie , Martin Jérôme , Fromont Patricia , Prié Nolwen , Thomas Caroline , Muller et Jean‐Yves 
Published: July 2011

To cite this article: Audrain M, Martin J, Fromont P, Prié N, Thomas C, Muller J‐Y. Autoimmune neutropenia in children: analysis of 116 cases. Pediatr Allergy Immunol 2011; 22: 494–496.Diagnosis of autoimmune neutropenia (AIN) in infants is important, because it allows the exclusion of more severe forms of neutropenia that have an increased risk for leukemia. AIN is characterized by chronic neutropenia, which spontaneously resolves within several months to a few years, and mild infections. Diagnosis is confirmed by the presence of antibodies directed against neutrophil antigens. The human neutrophil antigen (HNA) system is a polymorphic system, which includes five antigen groups with different polymorphisms. In AIN, antibodies are mostly directed against HNA‐1 (or against a specific allele of HNA‐1) and HNA‐4. Here, we present a series of 116 infants with AIN. We observed that anti‐neutrophil antibodies were present in 60% cases; directed against HNA‐1a in 73% of cases. In addition, we showed there was a bias in the HNA allele distribution in these infants because the frequency of the HNA‐1a allele was greater in comparison with controls.
Use of allergen components begins a new era in pediatric allergology
Authors: Borres Magnus P. , Ebisawa Motohiro , Eigenmann Philippe A. 
Published: July 2011

To cite this article: Borres MP, Ebisawa M, Eigenmann PA. Use of allergen components begins a new era in pediatric allergology. Pediatr Allergy Immunol 2011; 22: 454–461.AbstractMolecular allergology is a breakthrough science that enables the quantification of IgE and IgG antibodies against individual allergen protein components at a molecular level.The diagnosis of IgE‐mediated allergic disorder among children is based on clinical history and sensitization demonstrated through an allergy test. Identifying whether the sensitization is primary (species specific) or a result of cross‐reactivity to proteins with similar protein structures helps the clinician to judge the risk of allergic reaction. This is possible today because allergen component tests are now available for clinicians to use in everyday practice.This article focuses on clinical utility through the prediction of cross‐reactivity or primary sensitization, estimation of the risk of reaction to heated food and the risk of severe clinical symptoms.
Lophodermium needle cast, insect defoliation and growth responses of young Scots pines in Estonia
Authors: Hanso M. , Drenkhan R. 
Published: July 2011

SummaryUsing a retrospective approach, based on historical needle cast disease and insect pest records, data series of needle losses (reconstructed by the use of the needle trace method), tree growth parameters and meteorological data were studied to determine the impact of the appropriate pointer (epidemic or calamity) years on the annual radial and height increment of 46 sample trees in six Scots pine (Pinus sylvestris) stands in Estonia from 1887 to 2006. First, the needle cast epidemics during the last 120 years were retrospectively determined, with resulting 4.6 epidemics per decade as a mean frequency. If the sum of precipitation from May to August reached 300 mm (the mean of 12 epidemic years studied: 361 ± 15 mm), an epidemic of needle cast caused byLophodermium seditiosummight follow the next year in young plantations. For insect defoliators, similarly clear triggering threshold values of precipitation or temperature could not be determined, although dry and warm summers and mild winters supported the calamities. We separately detected that both larger needle losses and growth reductions in trees related to Lophodermium needle cast epidemic years lasted until the same age of pines, 22–24 years, but for insect pest (diprinoid sawflies) calamity years the growth reduction lasted longer. The relevance of these findings for the prediction of Lophodermium needle cast epidemics is briefly discussed.
Onychomycosis in patients with psoriasis – a multicentre study
Authors: Zisova L. , Valtchev V. , Sotiriou E. , Gospodinov D. , Mateev G. 
Published: July 2011

Summary1–3% of human population is affected by psoriasis. Nail disorders are reported in 10–80% of patients with psoriasis. Nail deformations vary according to their degree of severity but are mainly represented by pitting, Beau’s lines, hyperkeratosis, onycholysis, leuconychia or oil drops. Onychomycosis is a fungal infection of the nails, caused by dermatophytes, yeast and moulds. In this study, 228 patients with psoriasis aged between 18 and 72 were examined (48 – from Plovdiv, Bulgaria; 145 – from Pleven, Bulgaria and 35 – from Thessaloniki, Greece); 145 of them were male and 83 of them were female. The examination of the nail material was performed via direct microscopy with 20% KOH and nail samples plated out on Sabouraud agar methodology. The severity of the nail disorders was determined according to the Nail Psoriasis Severity Index (NAPSI). Positive mycological cultures were obtained from 62% of the patients with psoriasis (52%– Plovdiv, Bulgaria; 70%– Pleven, Bulgaria and 43%– Thessaloniki, Greece). In 67% of the cases, the infection was caused by dermatophytes, in 24% by yeast, in 6% by moulds and in 3% by a combination of causes. All patients with psoriasis were identified with high levels of NAPSI, whereas the ones with isolated Candida had even higher levels. Seventeen percentage of the patients have been treated with methotrexate, 6% have been diagnosed with diabetes and 22% have been reported with onychomycosis and tinea pedis within the family. An increased prevalence of onychomycosis among the patients with psoriasis was found. Dystrophic nails in psoriasis patients are more predisposed to fungal infections. The mycological examination of all psoriasis patients with nail deformations is considered obligatory because of the great number of psoriasis patients diagnosed with onychomycosis.
Update of fecal markers of inflammation in inflammatory bowel disease
Authors: Judd Thomas A , Day Andrew S , Lemberg Daniel A , Turner Dan , Leach Steven T 
Published: July 2011

AbstractThe diagnosis, prognosis, and assessment of disease activity of inflammatory bowel disease (IBD) require investigating clinical, radiological, and histological criteria, as well as serum inflammatory markers. However, a range of fecal inflammatory markers now appears to have the potential to greatly assist in these processes. Calprotectin, a prominent neutrophil protein, was identified two decades ago as a potentially revolutionary marker for IBD. Following this discovery, numerous additional markers, including S100A12, lactoferrin, and M2‐pyruvate kinase, have also been suggested as novel markers of IBD. In the present study, we provide an up‐to‐date review of fecal markers of IBD, and further, provide a novel analysis of each of these fecal markers in severe ulcerative colitis and compare their expression pattern in contrast to calprotectin.
The perioperative dialogue reduces postoperative stress in children undergoing day surgery as confirmed by salivary cortisol
Authors: Wennström Berith , Törnhage Carl‐Johan , Nasic Salmir , Hedelin Hans , Bergh Ingrid 
Published: July 2011

SummaryAim:  To evaluate the efficacy of ‘the perioperative dialogue (PD)’ by analyzing salivary cortisol, in 5‐ to 11‐year‐old children undergoing day surgery.Background:  To deal with anxiety prior to investigations and/or procedures, children need to be confident and informed about what is going to happen. Therefore, intervention strategies should be initiated before admission to hospital.Methods and materials:  Children (n = 93), 79 boys and 14 girls, scheduled for elective day surgery requiring general anesthesia were randomly recruited into three groups: (i) standard perioperative care (n = 31), (ii) standard perioperative care including preoperative information (n = 31), and (iii) the PD (n = 31). Saliva was sampled for cortisol analysis at specific time points during the pre‐ and perioperative procedures.Results:  The children who received the PD had significantly lower (P = 0.003) salivary cortisol concentrations postoperatively. Moreover, it continuously decreased during the day of surgery compared with the other two groups (P < 0.01). Among the children who received analgesics, the PD group received significantly less morphine (P = 0.014) related to bodyweight: the mean dose was 0.1 mg·kg−1 (n = 9) in the control group vs 0.04 mg·kg−1 (n = 6) in the PD group. Irrespective of group, there was a positive correlation between the children’s morphine consumption and salivary cortisol concentration (r = 0.56; P = 0.038). The W‐B scale score was higher in the group that received morphine (median = 3 vs median=1; P = 0.001).Conclusions:  The PD’s caring, continuity, and on‐going dialogues were associated with low concentrations of salivary cortisol postoperatively and reduced morphine consumption and thus appears to be a valuable complement to standard perioperative care in children undergoing day surgery.
The Mediterranean Sea under siege: spatial overlap between marine biodiversity, cumulative threats and marine reserves
Authors: Coll Marta , Piroddi Chiara , Albouy Camille , Ben Rais Lasram Frida , Cheung William W. L. , Christensen Villy , Karpouzi Vasiliki S. , Guilhaumon François , Mouillot David , Paleczny Michelle , Palomares Maria Lourdes , Steenbeek Jeroen , Trujillo Pablo , Watson Reg , Pauly Daniel 
Published: July 2011

ABSTRACTAim  A large body of knowledge exists on individual anthropogenic threats that have an impact on marine biodiversity in the Mediterranean Sea, although we know little about how these threats accumulate and interact to affect marine species and ecosystems. In this context, we aimed to identify the main areas where the interaction between marine biodiversity and threats is more pronounced and to assess their spatial overlap with current marine protected areas in the Mediterranean.Location  Mediterranean Sea.Methods  We first identified areas of high biodiversity of marine mammals, marine turtles, seabirds, fishes and commercial or well‐documented invertebrates. We mapped potential areas of high threat where multiple threats are occurring simultaneously. Finally we quantified the areas of conservation concern for biodiversity by looking at the spatial overlap between high biodiversity and high cumulative threats, and we assessed the overlap with protected areas.Results  Our results show that areas with high marine biodiversity in the Mediterranean Sea are mainly located along the central and north shores, with lower values in the south‐eastern regions. Areas of potential high cumulative threats are widespread in both the western and eastern basins, with fewer areas located in the south‐eastern region. The interaction between areas of high biodiversity and threats for invertebrates, fishes and large animals in general (including large fishes, marine mammals, marine turtles and seabirds) is concentrated in the coastal areas of Spain, Gulf of Lions, north‐eastern Ligurian Sea, Adriatic Sea, Aegean Sea, south‐eastern Turkey and regions surrounding the Nile Delta and north‐west African coasts. Areas of concern are larger for marine mammal and seabird species.Main conclusions  These areas may represent good candidates for further research, management and protection activities, since there is only a maximum 2% overlap between existing marine protected areas (which cover 5% of the Mediterranean Sea) and our predicted areas of conservation concern for biodiversity.
Do Recruitment Ties Affect Wages? An Analysis using Matched Employer–Employee Data from Vietnam
Authors: Larsen Anna Folke , Rand John , Torm Nina 
Published: July 2011

AbstractThis paper examines the extent to which recruitment ties affect individual wage outcomes in small and medium scale manufacturing firms. Based on a unique matched employer–employee dataset from Vietnam the authors find that there is a significant positive wage premium associated with obtaining a job through an informal contact, when controlling for standard determinants of wage compensation. Moreover, they show that the mechanism through which informal contacts affect wages depends on the type of recruitment tie used. The findings are robust across location, firm size categories, and different worker types.
Delayed pressure urticaria – Dapsone heading for first‐line therapy?
Authors: Grundmann Sonja Alexandra , Kiefer Sabine , Luger Thomas Anton , Brehler Randolf 
Published: July 2011

SummaryBackground: Pressure urticaria as a subform of physical urticaria is rare and treatment is often difficult. Established therapeutic regimes include antihistamines (generally exceeding approved dosages in order to achieve a therapeutic benefit) or antihistamines combined with montelukast. Complete relief of symptoms is difficult.Patients and methods: We used dapsone as an early therapeutic alternative in the event of treatment failure and established a standardized therapeutic regime at our clinic. We surveyed 31 patients retrospectively who had received dapsone between 2003–2009.Results: In 74 % of patients in whom symptoms persisted despite established therapies, the results of treatment with dapsone were good or very good. Longer‐term pressure urticaria and the co‐existence of a chronic spontaneous urticaria were associated with a smaller benefit (p<0.05). No significant effects were found related to age, gender, duration of therapy, side‐effects, or Met‐Hb elevation (a tendency toward a decreased benefit was associated with middle‐age, male sex, shorter duration of therapy, observed side‐effects, and Met‐Hb elevation).Conclusions: Therapy is well tolerated and results in a good therapeutic benefit which lasts after termination of therapy. With adequate monitoring, the use of dapsone in patients with pressure urticaria has such a good risk‐benefit ratio that we support early treatment initiation.
Enhanced sensitivity to cisplatin and gemcitabine in Brca1-deficient murine mammary epithelial cells
Authors: Alli Elizabeth , Sharma Vandana B , Hartman Anne-Renee , Lin Patrick S , McPherson Lisa , Ford James M 
Published: July 2011

Abstract

Background
Breast cancers due to germline mutations or altered expression of the BRCA1 gene associate with an aggressive clinical course and frequently exhibit a "triple-negative" phenotype, i.e. lack of expression of the estrogen and progesterone hormone receptors and lack of overexpression of the HER2/NEU oncogene, thereby rendering them relatively insensitive to hormonal manipulation and targeted HER2 therapy, respectively. BRCA1 plays a role in multiple DNA repair pathways, and thus, when mutated, results in sensitivity to certain DNA damaging drugs.

Results
Here, we used a Brca1 murine mammary epithelial cell (MMEC) model to examine the effect of loss of Brca1 on cellular sensitivity to various chemotherapy drugs. To explore novel therapeutic strategies, we included DNA damaging and non-DNA damaging drugs whose mechanisms are dependent and independent of DNA repair, respectively, and drugs that are used in standard and non-standard lines of therapy for breast cancer. To understand the cellular mechanism, we also determined the role that DNA repair plays in sensitivity to these drugs. We found that cisplatin and gemcitabine had the greatest specific therapeutic benefit to Brca1-deficient MMECs, and that when used in combination produced a synergistic effect. This sensitivity may be attributed in part to defective NER, which is one of the DNA repair pathways normally responsible for repairing DNA adducts produced by cisplatin and is shown in this study to be defective in Brca1-deficient MMECs. Brca1-deficient MMECs were not differentially sensitive to the standard breast cancer chemotherapy drugs doxorubicin, docetaxel or 5-FU.

Conclusions
Both cisplatin and gemcitabine should be explored in clinical trials for first line regimens for BRCA1-associated and triple-negative breast cancer.
Elevated Oxidative Damage in Kitchen Workers in Chinese Restaurants
Authors: Wang Jiajia , Luo Xiaolin , Xu Bin , Wei June , Zhang Zhenzhen , Zhu Huilian 
Published: July 2011

Elevated Oxidative Damage in Kitchen Workers in Chinese Restaurants: Jiajia Wang, et al. School of Public Health, Sun Yat‐Sen University, China—ObjectivesTo investigate associations between occupational exposure to cooking oil fumes (COFs) and potential oxidative and genotoxic effects in kitchen workers.MethodsSixty‐seven male kitchen workers and 43 male controls from Chinese restaurants in Guangzhou were recruited. For all the participants, the levels of 1‐hydroxypyrene (1‐OHP) and 8‐hydroxy2‐deoxyguanosine (8‐oxodG) in urine, binucleated micronucleus (BNMN) frequency, comet tail length and tail DNA% in peripheral blood lymphocytes (PBLs) and malondialdehyde (MDA) and superoxide dismutase (SOD) in serum were measured. The inhalable particulates (PM10) in their workplaces were also monitored.ResultsOur results showed that the exposed group had a significantly higher median level of urinary 1‐OHP than that of the control group (p<0.01). In addition, the median levels of 8‐oxodG, BNMNs, tail length and MDA in the exposed group were markedly higher than those of the controls (p<0.01). These differences, except that of MDA, appeared not to be modified by the potential confounders: age, BMI, smoking and alcohol consumption. A univariate regression analysis showed that greater 1‐OHP, 8‐oxodG, BNMNs, tail length and MDA were associated with years working in a kitchen and cooking time per day. All these positive associations remained after adjusting for the four confounders in a subsequent multivariate linear regression analysis.ConclusionsOccupational exposure to COFs led to increased oxidative damage in Chinese kitchen workers. The health consequences of these oxidative changes need further investgation. Urinary 1‐OHP and 8‐oxodG are noninvasive and effective biomarkers for assessment of oxidative damage in restaurants workers.
Successions et héritiers à travers les données fiscales
Authors: Arrondel Luc , Laferrère Anne 
Published: July 2011

Successions et héritiers à travers les données fiscales,
par Luc Arrondel, Anne Laferrère.

L'article décrit les comportements des Français en matière d'héritage à partir d'un échantillon de 3 200 déclarations de successions enregistrées par les services fiscaux en 1987, qui correspondent à la transmission de 125 millions de francs par 263 000 personnes, soit la moitié des défunts de l'année. La succession augmente avec le revenu du foyer fiscal du défunt. Son élasticité par rapport au revenu est inférieure à 1 chez les 80% les plus pauvres en revenu et supérieure à l'unité chez les plus riches. Le montant global de la succession est supérieur en présence d'enfants. Il n'y a pas substitution entre l'héritage matériel et l'héritage en capital humain tel qu'il est approché par la catégorie sociale ou par le revenu de l'enfant héritier (anti-compensation des ressources). Au contraire, les héritages les plus élevés vont aux enfants les mieux dotés. Cette absence de compensation s'observe aussi dans les cas où la succession est effectivement partagée inégalement entre les enfants (7% des cas).
Coïntégration et modèles dynamiques
Authors: d'Autume Antoine 
Published: July 2011

Cointegración y modelos dinámicos,
por Antoine d'Autume.

Las propiedades de integración y de cointegración reflejan las propiedades dinámicas importantes de los modelos macroeconómicos, que se trata de explicar detalladamente en este artículo, hatiendo resaltar la estrecha correspondentia que existe entre propiedades deterministas, relativas a las tasas de crecimiento, y propiedades estocásticas. Este análisis va seguido de una reflexión general acerca de las causas de aparición de raíces unitarias en los modelos macroeconómicos.
Structure par terme des taux d'intérêt et reprise économique
Authors: Artus Patrick , Kaabi Moncef 
Published: July 2011

The Term-by-Term Structure of Interest Rates and Economic Recovery,
by Patrick Artus and Moncef Kaabi.

We examine the validity of the theory by which economic recovery is always preceded by an upturn in the term-by-term interest-rate structure curve. We study the data for the leading countries and compare them with information derived from a simple theoretical model, which introduces a number of possibilities for shocks leading to an increase in real activity.
Taux de sortie du chômage à l'approche de la fin des droits à l'indemnisation. Une étude de périodes atypiques durant l'épisode de chômage
Authors: Joutard Xavier , Ruggiero Michèle 
Published: July 2011

The Rate of Exits from Unemployment Towards the End of Unemployment Benefits A Study of Atypical Periods During the Unemployment Episode,
by Xavier Joutard and Michèle Ruggiero.

This article looks at the imminence of benefit-scheme changes, using the June 1989 Fichier national des allocataires (French national file of welfare recipients). It is considered that the period around a scheme change is an atypical period in the unemployment episode. Duration models are estimated over these particular time intervals. The aim is to identify the characteristics of individuals whose rate of exit from unemployment increases as a drop in replacement income draws near.