bluuebunny/crossref_metadata_2025_split huggingface dataset:
A CORPUS‐DRIVEN STUDY OF THE CORRELATION BETWEEN THE SYNTACTIC COMBINATION STRENGTH AND THE SEMANTIC CONTRIBUTION IN THE ENGLISH “V‐TO‐V” CONSTRUCTION
Authors: Zhang Yalin , He Qingshun 
Published: May 2024

AbstractThis paper conducted a corpus‐driven study on the syntactic and semantic features of the first verb and the to‐infinitive in the “V‐to‐V” construction. It was found that the syntactic combination strength of the “V‐to‐V” construction and the semantic contribution of the first verb are in general negatively correlated. The “V‐to‐V” construction can, therefore, be classified into three types: (1) Hypotactic clause complex of expansion, where the two verbs in the “V‐to‐V” construction construe the two processes, with weak syntactic combination and high semantic contribution of the first verb; (2) Single verbal group, where the two verbs construe one process with the first verb being auxiliary, with strong syntactic combination and low semantic contribution of the first verb; (3) Hypotactic clause complex of projection, where the two verbs construe two processes, with flexible syntactic combination and high semantic contribution of the first verb. Such correlation can thus form a cline from hypotactic clause complex of expansion through hypotactic clause complex of projection to single verbal groups.
Opportunities to improve feedback to reduce blood component wastage: Results of a national scheme evaluation
Authors: Staples Sophie , Evans Hayley , Caulfield Jill , Bend Matthew , Foy Robbie , Murphy Michael F. , Stanworth Simon J. 
Published: May 2024

AbstractBackgroundBlood components are costly and scarce. The Blood Stocks Management Scheme (BSMS) was established in the United Kingdom (UK) to support hospital transfusion services and national blood services through collection, analysis, and monthly feedback of data on blood component inventory and wastage management. There is a growing evidence base on how best to deliver feedback for quality improvement. We assessed the quality and utility of the monthly BSMS component reports.MethodsWe assessed the content of BSMS reports issued in March 2023 against established criteria for effective feedback. Two researchers independently rated whether criteria spanning the five domains of goal setting, data collection, feedback content, feedback display and feedback delivery were fully, partially or not met. Disagreements were resolved through discussion. We conducted an online questionnaire survey of recipients of BSMS reports during March 2023 to assess their use of reports and seek suggestions for improvement.ResultsFive out of 20 criteria for effective feedback were fully met. Areas for improvement included placing more emphasis in the feedback on positive change, linking data and summary messages, and including specific suggestions for action. Respondents highlighted the value of benchmarked comparisons with other hospital transfusion services.ConclusionThere is scope for enhancing the effectiveness and utility of BSMS feedback reports and hence reducing wastage of blood components. This methodology for evaluation of feedback could be utilized to improve other areas of transfusion practice.
Salmonella Typhimurium caused an unprecedentedly large foodborne outbreak in Finland in 2021
Authors: Lehti Satu‐Mari , Andersen Ole , Leppäaho‐Lakka Jaana , Suominen Eija , Vainio Anni , Matsinen Maire , Kuronen Henry , Rimhanen‐Finne Ruska 
Published: May 2024

AbstractAimsSalmonella infections are significant causes of foodborne outbreaks in the European Union. This study investigates a sudden increase in gastroenteritis patients in the hospital district of Central Finland in June 2021. The primary aim was to study the outbreak's magnitude and source of the outbreak.Methods and ResultsEpidemiological, microbiological, environmental and traceback investigations were conducted. Over 700 persons fell ill during the outbreak caused by Salmonella Typhimurium associated with a daycare lunch. Similar S. Typhimurium was found in the patients and a vegetable mix containing iceberg lettuce, cucumber and peas served during lunch. The traceback investigation revealed that the batch information of vegetables from the wholesaler was not complete. The wholesaler had received quality complaints about the iceberg lettuce from the central kitchen. The manufacturer did not test the suspected batch for Salmonella since the production plant had given a certificate declaring it Salmonella negative.ConclusionsThe most suspect ingredient was one batch of iceberg lettuce due to quality complaints. The lettuce had not been served in two daycare centres without cases. We recommend that in order to enable thorough microbiological investigation, institutional kitchens store the food samples separately as part of the internal quality control and that food items should always be tested when Salmonella contamination in an outbreak is suspected.
Influence of the Novel Coronavirus Disease on Nigerian Real Estate Sector and the Way Forward
Authors: Keke Onyinye Vivian , Okafor Johnbosco Ikenna , Sado Raphael Oshiobugie 
Published: May 2024

The coronavirus disease outbreak which occurred in 2019 at Wuhan, Hubei Province in China became a pandemic in 2020 such that over 200 countries have been affected and had to lockdown on economic, social and political activities so as to maintain both social and physical distancing to curb the dispersion of the virus. Global economic growth came to an abrupt halt, as a result of the effects of the pandemic on social and economic activities - countries around the world have implemented changes to real estate policies in order to reduce the effects of the lockdown on the citizens who are tenants and, in some cases, landlords. In the United States, many decisions are made at the state and local levels to prohibit eviction of tenants. Many countries are considering legislations that would protect tenants who cannot pay rent for a period of six months. Due to this global lockdown resulting from the pandemic, Nigeria is currently facing financial crisis which has directly/indirectly affected all sectors of human endeavor including the real estate sector of the economy. In all, the usual way of life and work system is changing and some of the upcoming trends will become part of the ‘new normal’ in the Nigerian real estate sector. The researchers used survey method in obtaining data by distributing questionnaires to respondents. Data collected were collated and analyzed using table, simple percentage and mean. Findings reveal that the outbreak has had an adverse effect on many tenants’ ability to pay rents and have also led to a decrease in investment yield for residential and commercial real estate as a result of the economic "lockdown" in the country. The study suggests that, although all forms of real estate investment produce viable returns, it will be a wise investment decision to capitalize on the agricultural real estate sector during this pandemic as well as the post-COVID era. It also recommends that the Nigerian government should create an enabling environment to encourage investors, by coming up with policies that will help ease the effect of the pandemic on real estate investment.
Active Vibration Control on a Tire–Wheel Assembly Using Piezoelectric Spatial Modal Filter
Authors: Carvalho Antoine , Billon Kevin , Rodriguez Jonathan , Chesne Simon , Lohr François 
Published: May 2024

Abstract
Vibrations due to tire–road contact in wheeled vehicles induce acoustic discomfort especially beyond 35 km/h. This paper proposes an active control method to reduce the vibration transmission from the tire–road contact to the vehicle through piezoelectric transducers located directly on the wheel spokes. Our approach relies on a double spatial modal filter to physically focus the control energy on the wheel pumping mode while avoiding any spillover phenomena. In addition, a bandpass controller ensures maximum damping on the targeted mode. The proposed control strategy is applied first to the clamped wheel in order to validate the static performance of the spatial controller. Then the wheel is excited through the tire and the efficiency of the controller is evaluated through the measured force passing by the wheel hub. Finally, the tire–wheel assembly (TWA) is placed on an experimental setup recreating the vehicle operating conditions with wheel rotation at different velocities and road excitations. The experimental results confirm the efficiency of the proposed control method and its robustness to the dynamics evolution of the structure in function of the TWA angular velocity.
Effect of Interlayer Machining Interventions on the Geometric and Mechanical Properties of Wire Arc Directed Energy Deposition Parts
Authors: Rashid Asif , Kota Akshar , Boing Denis , Melkote Shreyes N. 
Published: May 2024

Abstract
Wire arc directed energy deposition (Wire Arc DED) has become a popular metal additive manufacturing technique for its capability to print large metal parts at a high deposition rate while being economically efficient. However, the Wire Arc DED process exhibits geometric inaccuracies resulting from the variability in the bead geometry and demonstrates heterogeneity in microstructure and mechanical properties. This study investigates the use of tailored periodic machining interventions during the Wire Arc DED process to address these shortcomings. The as-built geometry and surface finish, microstructure, and microhardness of multilayer wall structures produced with and without machining interventions carried out at different temperatures are compared. The machining interventions are found to reduce the uncertainty in bead geometry evolution and significantly improve the surface roughness of the as-built walls, thus reducing the need for further postprocessing of the wall surfaces. Although the microstructure constituents of the as-built wall structures with and without machining interventions are similar, the machining interventions result in finer grains in the interior of the part. Machining interventions are found to yield a statistically significant increase in microhardness, indicating increased strength compared to Wire Arc DED alone. In addition, the spread of the microhardness distribution is reduced in Hybrid Wire Arc DED, indicating improved homogeneity of the grain size distribution compared to Wire Arc DED alone. The study shows that the proposed hybrid manufacturing technique has the potential to control and improve the geometric and mechanical properties of additively manufactured metal components.
Sport Management Research Productivity and Impact for Ranking Considerations
Authors: Seifried Chad , Martinez J. Michael , Qian Yizhou , Zvosec Claire , Svensson Per G. , Soebbing Brian P. , J.A. Agyemang Kwame 
Published: May 2024

The present essay aims to promote further dialogue within the sport management community about research productivity and impact by outlining various considerations that should take place within any potential ranking attempt. Some may question why examining research production and impact matters to sport management education, but the mission of many institutions of higher education is not exclusively centered on teaching and training the next generation of leaders. In many instances, sport management programs and faculty are collectively compelled by their host institution to develop theory and search for answers to important questions that can shape future sport management practices, including classroom activities and materials. In the present essay, a rationale is provided for why sport management programs and individual faculty should be interested in developing their own tailored research output and impact rankings. Next, a list of research product variables is offered for consideration, and a conversation is provided about their need and impact with respect to the uniqueness of sport management—a multi-interdisciplinary field. Finally, recommendations for the weighing of such variables to tailor an approach best suited to programs based on college or department home, faculty appointment/workload, and faculty-to-student ratio are submitted.
Pseudomonas aeruginosa
two-component system LadS/PA0034 regulates macrophage phagocytosis via fimbrial protein cupA1
Authors: Guo Xiaolong , Yu Hua , Xiong Junzhi , Dai Qian , Li Yuanyuan , Zhang Wei , Liao Xiping , He Xiaomei , Zhou Hongli , Zhang Kebin 
Published: May 2024

ABSTRACT

Pseudomonas aeruginosa
is one of the most common nosocomial pathogens worldwide, known for its virulence, drug resistance, and elaborate sensor-response network. The primary challenge encountered by pathogens during the initial stages of infection is the immune clearance arising from the host. The resident macrophages of barrier organs serve as the frontline defense against these pathogens. Central to our understanding is the mechanism by which bacteria modify their behavior to circumvent macrophage-mediated clearance, ensuring their persistence and colonization. To successfully evade macrophage-mediated phagocytosis, bacteria must possess an adaptive response mechanism. Two-component systems provide bacteria the agility to navigate diverse environmental challenges, translating external stimuli into cellular adaptive responses. Here, we report that the well-documented histidine kinase, LadS, coupled to a cognate two-component response regulator, PA0034, governs the expression of a vital adhesin called chaperone-usher pathway pilus cupA. The LadS/PA0034 system is susceptible to interference from the reactive oxygen species likely to be produced by macrophages and further lead to a poor adhesive phenotype with scantily cupA pilus, impairing the phagocytosis efficiency of macrophages during acute infection. This dynamic underscores the intriguing interplay: as macrophages deploy reactive oxygen species to combat bacterial invasion, the bacteria recalibrate their exterior to elude these defenses.

IMPORTANCE

The notoriety of
Pseudomonas aeruginosa
is underscored by its virulence, drug resistance, and elaborate sensor-response network. Yet, the mechanisms by which
P. aeruginosa
maneuvers to escape phagocytosis during acute infections remain elusive. This study pinpoints a two-component response regulator, PA0034, coupled with the histidine kinase LadS, and responds to macrophage-derived reactive oxygen species. The macrophage-derived reactive oxygen species can impair the LadS/PA0034 system, resulting in reduced expression of cupA pilus in the exterior of
P. aeruginosa
. Since the cupA pilus is an important adhesin of
P. aeruginosa
, its deficiency reduces bacterial adhesion and changes their behavior to adopt a planktonic lifestyle, subsequently inhibiting the phagocytosis of macrophages by interfering with bacterial adhesion. Briefly, reactive oxygen species may act as environmental cues for the LadS/PA0034 system. Upon recognition,
P. aeruginosa
may transition to a poorly adhesive state, efficiently avoiding engulfment by macrophages.
Phenotypic characterization of cryptic species in the fungal pathogen
Histoplasma
Authors: Sepúlveda Victoria E. , Rader Jonathan A. , Li Jingbaoyi (Janet) , Goldman William E. , Matute Daniel R. 
Published: May 2024

ABSTRACT

Histoplasmosis is an endemic mycosis that often presents as a respiratory infection in immunocompromised patients. Hundreds of thousands of new infections are reported annually around the world. The etiological agent of the disease,
Histoplasma,
is a dimorphic fungus commonly found in the soil where it grows as mycelia. Humans can become infected by
Histoplasma
through inhalation of its spores (conidia) or mycelial particles. The fungi transition into the yeast phase in the lungs at 37°C. Once in the lungs, yeast cells reside and proliferate inside alveolar macrophages. Genomic work has revealed that
Histoplasma
is composed of at least five cryptic phylogenetic species that differ genetically. Three of those lineages have received new names. Here, we evaluated multiple phenotypic characteristics (colony morphology, secreted proteolytic activity, yeast size, and growth rate) of strains from five of the phylogenetic species of
Histoplasma
to identify phenotypic traits that differentiate between these species:
Histoplasma capsulatum sensu stricto
,
Histoplasma ohiense
,
Histoplasma mississippiense
,
Histoplasma suramericanum
, and an African lineage. We report diagnostic traits for three species. The other two species can be identified by a combination of traits. Our results suggest that (i) there are significant phenotypic differences among the cryptic species of
Histoplasma
and (ii) those differences can be used to positively distinguish those species in a clinical setting and for further study of the evolution of this fungal pathogen.

IMPORTANCE

Identifying species boundaries is a critical component of evolutionary biology. Genome sequencing and the use of molecular markers have advanced our understanding of the evolutionary history of fungal pathogens, including
Histoplasma
, and have allowed for the identification of new species. This is especially important in organisms where morphological characteristics have not been detected. In this study, we revised the taxonomic status of the four named species of the genus
Histoplasma, H. capsulatum sensu stricto
(
ss
),
H. ohiense
,
H. mississippiense
, and
H. suramericanum,
and propose the use of species-specific phenotypic traits to aid their identification when genome sequencing is not available. These results have implications not only for evolutionary study of
Histoplasma
but also for clinicians, as the
Histoplasma
species could determine the outcome of disease and treatment needed.
Patient preferences for prophylactic regimens requiring regular injections in children and adolescents: a systematic review and thematic analysis
Authors: Ilievski Jana , Mirams Olivia , Trowman Rebecca , Barr Renae K , Manning Laurens 
Published: May 2024

BackgroundAt present, limited literature exists exploring patient preferences for prophylactic treatment of acute rheumatic fever (ARF) and rheumatic heart disease (RHD). Given low treatment completion rates to this treatment in Australia, where the burden of disease predominantly affects Aboriginal and Torres Strait Islander people, an improved understanding of factors driving patient preference is required to improve outcomes. Due to limited available literature, this review sought to explore treatment preferences for conditions for which the findings might be generalisable to the ARF/RHD context.ObjectiveExplore treatment preferences of patients, parents/caregivers and healthcare providers towards regular injection regimens in paediatric and adolescent populations for any chronic condition. Findings will be applied to the development of benzathine penicillin G (BPG) prophylactic regimens that are informed by treatment preferences of patients and their caregivers. This in turn should contribute to optimisation of successful BPG delivery.MethodsA systematic review of databases (Medline, Embase and Global Health) was conducted using a search strategy developed with expert librarian input. Studies were selected using a two-stage process: (1) title and abstract screen and (2) full text review. Data were extracted using a reviewer-developed template and appraised using the JBI Critical Appraisal tool. Data were synthesised according to a thematic analytical framework.Results1725 papers were identified by the database search, conducted between 12 February 2022 and 8 April 2022, and 25 were included in the review. Line-by-line coding to search for concepts generated 20 descriptive themes. From these, five overarching analytical themes were derived inductively: (1) ease of use, (2) tolerability of injection, (3) impact on daily life, (4) patient/caregiver agency and (5) home/healthcare interface.ConclusionsThe findings of this review may be used to inform the development of preference-led regular injection regimens for paediatric and adolescent patient cohorts—specifically for BPG administration in ARF/RHD secondary prophylaxis.Trial registration numberPatient, parent and health personnel preferences towards regular injection regimes in paediatric and adolescent populations—a protocol for a systematic review. PROSPERO 2021 CRD42021284375. Available from:https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42021284375.
Patterns and organ treatment response of Erdheim-Chester disease with cardiac involvement
Authors: Miao Hui-lei , Chang Long , Lin He , Liu Zheng-zheng , Wu Wei , Niu Na , Cao Xin‑xin 
Published: May 2024

ObjectiveTo evaluate the heart response of Erdheim-Chester disease (ECD) through continuous follow-up within our large cohort, for which there is a lack of understanding.MethodsWe conducted a retrospective analysis of clinical data from patients with ECD with cardiac involvement diagnosed at our centre between January 2010 and August 2023. We assessed the heart response by integrating pericardial effusion and metabolic responses.ResultsA total of 40 patients were included, with a median age of 51.5 years (range: 29–66) and aBRAFV600Emutation rate of 56%. The most common imaging manifestations observed were pericardial effusion (73%), right atrium (70%) and right atrioventricular sulcus infiltration (58%). Among 21 evaluable patients, 18 (86%) achieved a heart response including 5 (24%) complete response (CR) and 13 (62%) partial response (PR). The CR rate of pericardial effusion response was 33%, while the PR rate was 56%. Regarding the cardiac mass response, 33% of patients showed PR. For cardiac metabolic response, 32% and 53% of patients achieved complete and partial metabolic response, respectively. There was a correlation between pericardial effusion response and cardiac metabolic response (r=0.73 (95% CI 0.12 to 0.83), p<0.001). The median follow-up was 50.2 months (range: 1.0–102.8 months). The estimated 5-year overall survival was 78.9%. The median progression-free survival was 59.4 months (95% CI 26.2 to 92.7 months). Patients who receivedBRAFinhibitors achieved better heart response (p=0.037) regardless of treatment lines.ConclusionWe pioneered the evaluation of heart response of ECD considering both pericardial effusion and cardiac metabolic response within our cohort, revealing a correlation between these two indicators.BRAFinhibitors may improve heart response, regardless of the treatment lines.