bluuebunny/crossref_metadata_2025_split huggingface dataset:
ChemInform Abstract: Simple, Stereocontrolled Syntheses of 24(S),25‐Epoxy‐22(R)‐hydroxycholesterol, 22(R),24(S)‐Dihydroxycholesterol and Diastereomers, New Ligands for Binding and Activation of LXRs.
Authors: Corey E. J. , Grogan Michael J. 
Published: June 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: A Novel Fragmentation‐Cyclization Reaction of Steroidal α‐Hydroxy Oximes.
Authors: Penov‐Gasi Katarina , Miljkovic Dusan , Medic‐Mijacevic Ljubica , Durendic Evgenija , Petrovic Julijana , Pejanovic Vjera , Stankovic Slobodanka , Lazar Dusan 
Published: June 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis of (S)‐ and (R)‐1‐(2‐Furyl)alkylamines and (S)‐ and (R)‐α‐Amino Acids Through the Addition of Organometallic Reagents to Imines Derived from (S)‐Valinol.
Authors: Alvaro Giuseppe , Martelli Gianluca , Savoia Diego , Zoffoli Andrea 
Published: June 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Stereoselective Synthesis of α‐C‐D‐Gluco‐ and D‐Galactopyranosyl Glycosides from an Isoprenoid Synthon.
Authors: Jegou Anne , Pacheco Carole , Veyrieres Alain 
Published: June 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Novel Synthesis of Enantiomerically Pure Natural Inositols and Their Diastereomers.
Authors: Takahashi Hideyo , Kittaka Hisae , Ikegami Shiro 
Published: June 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Stereoselective Sulfoxidation of α‐Mannopyranosyl Thioglycosides: The exo‐Anomeric Effect in Action.
Authors: Crich David , Mataka Jan , Sun Sanxing , Lam K.‐C. , Rheingold Arnold L. , Wink Donald J. 
Published: June 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Total Synthesis of (‐)‐γ‐Lycorane Using Diastereoselective 5‐endo‐trig Radical Cyclization of N‐Vinylic α‐Halo Amides.
Authors: Ikeda Masazumi , Ohtani Shinji , Sato Tatsunori , Ishibashi Hiroyuki 
Published: June 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: New NO Donors with Antithrombotic and Vasodilating Activities. Part 26. Amidoximes and Their Prodrugs.
Authors: Rehse Klaus , Brehme Franziska 
Published: June 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Mechanisms of Initial Dissociative Chemisorption of Oxygen on Transition‐Metal Surfaces
Authors: Nolan Peter D. , Wheeler M. Clay , Davis John E. , Mullins C. Buddie 
Published: June 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Stereochemistry of Zirconium and Hafnium Fluoro Complexes
Authors: Davidovich R. L. 
Published: June 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Design of Constrained Analogues of Amino Acids and Their Incorporation in the Sequence of Substance P
Authors: Ayoub Mimoun , Brunissen Alie , Josien Hubert , Loffet Albert , Chassaing Gerard , Lavielle Solange 
Published: June 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Examples of Active Areas of Structure‐Based Design
Authors: Gubernator K. , Boehm H. J. 
Published: June 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Novel Five‐ and Six‐ Membered Bisheterocyclic Systems from Dithiocarbamates and Related Compounds
Authors: Franco Santiago , Merchan Francisco L. , Merino Pedro , Tejero Tomas 
Published: June 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Polymer‐Assisted Solution Phase (PASP) Chemical Library Synthesis
Authors: Flynn Daniel L. , Devraj Rajesh V. , Naing Win , Parlow John J. , Weidner John J. , Yang Syaulan 
Published: June 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: From Olefin Cyclopropanation to Olefin Metathesis Through Catalyst Engineering: Recent Applications of Olefin Metathesis to Fine Organic Synthesis and to Polymer Chemistry
Authors: Noels A. F. , Demonceau A. 
Published: June 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Whole blood flow cytometric measurement of NFATc1 and IL‐2 expression to analyze cyclosporine A‐mediated effects in T cells
Authors: Brandt Claudia , Liman Peter , Bendfeldt Hanna , Mueller Karin , Reinke Petra , Radbruch Andreas , Worm Margitta , Baumgrass Ria 
Published: June 2010

AbstractThe calcineurin inhibitor Cyclosporine A (CsA) is one of the crucial immunosuppressive drugs given after organ transplantation. The small therapeutic window of CsA generates the dilemma that efficient and toxic drug doses differ only slightly. Moreover, these threshold concentrations differ considerably between individuals; therefore, functional assays are urgently needed. We explored whether the transcription factor NFATc1, a direct as well as indirect target of CsA, can be used as a potential biomarker to determine the individual immunosuppressive activity of CsA. First, in isolated human T cells we showed that flow cytometry is practicable to measure NFATc1, the most abundant NFATc isoform in activated T cells. Second, for whole blood we developed a flow cytometric assay to determine in parallel the inducible transcription factor NFATc1 and the cytokine IL‐2 in stimulated T cells. We found that added CsA inhibits both the expression of NFATc1 and IL‐2 in T cells of stimulated whole blood samples with IC50 values of 200 and 150 nM, respectively. The intra‐ and inter‐assay variability was low, and clinical practicability was good. Further experiments have to demonstrate whether the parallel cytometric measurement of NFATc1 and IL‐2 in whole blood is a good predictor of individual CsA efficacy and toxicity in CsA‐treated patients. © 2010 International Society for Advancement of Cytometry.
The influence of the thymus on the development of transplanted mammary tumour in mice
Authors: Belyaev D. K. , Gruntenko E. V. 
Published: June 2010

AbstractThe influence of thymectomy and the grafting of additional thymuses on the development of syngeneic mammary tumour has been studied in high cancer C3H/He strains of mice. The effect on the development of the grafted tumour of replacement of the thymus of F1 hybrid mice (C3H/HexC57BL) by thymus derived from donors of the parental streins has also been investigated.In C3H/He mice thymectomized on the 3rd day after birth the development of mammary tumour grafted at the age of 2 months was delayed. One or three additional syngeneic thymuses from 1‐month‐old donors grafted subcutaneously to C3H/He mice stimulated the development of grafted tumours, whereas inhibition of tumour development was observed in mice grafted with five additional thymuses.The replacement of the thymus in F1 hybrid mice (C3H/HexC57BL) at the 5th day after birth by thymus of 5‐day‐old donors of low cancer C57BL strain led to the inhibition of mammary tumour grafted to mice at 2‐3 months of age, while the replacement of the hybrid thymus by that obtained from donors of the high cancer C3H/He strain had no inhibitory effect.The data presented have been interpreted as evidence for genetically determined differences in the functional specificity of the thymus concerning its influence on malignant growth in high and low cancer strain mice. It is suggested that hereditary predisposition to malignant growth is, in particular, related to the functional properties of the thymus in high cancer strains of mice.
The origin of human embryo lung cells in culture: A comment on cell differentiation, in vitro growth and neoplasia
Authors: Franks L. M. , Cooper T. W. 
Published: June 2010

AbstractThe ultrastructure of cells derived from 15 human embryo lung culture lines, at 11 different transfer generations (2nd–19th) was examined, and compared with that of cells present in starting cell suspensions and explants. Differentiated epithelial cells were not seen after the second transfer generation. Two predominant cell types were present in all cultures. These cells were morphologically similar to endothelial cells and pericytes present in the initial explants. It is suggested that many tissue culture cell lines established from normal tissues may be derived from these cell types.Since some differentiated tumour cells with recognizable tissue markers can be maintained in vitro, under similar culture conditions the “normal” cells must have similar metabolic pathways, and therefore may not be satisfactory control material for biochemical and other studies of normal and tumour cells. The ability of differentiated cells to become established in vitro seems to be associated with the development of neoplastic characters.
Analyse quantitative in vivodes réctions immunitaires dirigées contre les antigénes associés a des tumeurs murines solides
Authors: Donner M. , Oth D. , Vaillier D. , Burg C. 
Published: June 2010

AbstractThe dose‐response curves and the TD50 are considered to be biological characteristics of tumors. Further these parameters vary according to the immunological status of the host. By using the TD50 method, a quantitative in vivo determination has been made of immune reactions directed against tumor‐associated transplantation antigens (TATA) of three solid murine tumors. The intensity of the primary immune reaction is evaluated by the difference between the TD50 values in normal and immune‐depressed animals. On the other hand, the secondary immune response is estimated by the difference between the TD50 in normal and specifically immunized recipients.According to these criteria, the results show that the intensity of the primary and secondary immune reactions cannot be compared from one tumor to another. For one tumor, the secondary reaction is quantitatively much greater than the primary reaction. For another tumor, the exact opposite is the case. These results suggest that there is no correlation between the primary and secondary immune responses and that they are quantitatively dependent upon multiple factors. The results are discussed in relation to the determination of antigenic strength of tumors.
The response of immunologically reconstituted mice to allogeneic skin or tumour grafts
Authors: Weston B. J. , Cheers C. , Carter R. L. , Leuchars E. , Wallis V. J. , Davies A. J. S. 
Published: June 2010

AbstractA study has been made of cytological and histological changes in lymph nodes draining grafts of allogeneic skin or tumour. The two types of graft provoked mitosis of both thymus‐ and bone‐marrow‐derived lymphocytes; this activity was associated with reactive changes initially in the paracortex and then in germinal centrts and medullary cords. Grafts of allogeneic skin evoked two peaks of mitosis which declined rapidly as the graft was rejected. Transient mitotic activity also occurred in response to (control) syngeneic skin, coinciding with increased lymph‐node weight and some paracortical hyperplasia but (cf. changes found after allografting), other parts of the node did not respond. Allogeneic EL4 lymphoma cells gave rise to a greater and more rapid immunological response than did skin grafting. The mitotic response to the injected tumour cells failed, at least in the draining lymph nodes, long before death of the host due to progressive tumour growth. It is suggested that both the greater mitotic response, and its later failure, are related to the progressive growth of the tumour and to the everincreasing antigenic burden which such a tumour represents.
Inhibition of ascites tumor development by concanavalin a
Authors: Inbar Michael , Ben‐Bassat Hannah , Sachs Leo 
Published: June 2010

AbstractThe protein concanavalin A (Con. A) that binds to glucose or mannose‐like sites on the cell surface membrane, and glycoproteins from wheat germ and soybean that bind to N‐acetyl‐D‐glucosamine‐like sites and N‐acetyl‐D‐galactosamine‐like sites, respectively, agglutinate cells of the ascites form of a Moloney virus‐induced lymphoma (YAC) grown in vivo. Although YAC cells were agglutinated by all three agglutinins, only Con. A showed a marked toxic effect on YAC cells in vitro and in vivo. In vitro incubation with 125μMg Con. A for 24 h lysed 95% of the cells. Intraperitoneal injection of 1 mg Con. A at 1 h, 2 days and 5 days after intraperitoneal inoculation of 102 YAC cells into adult mice, resulted in an inhibition of tumor formation in 70%, 50% and 20% of the animals, respectively. The results indicate that activities essential for cell survival are associated with Con. A sites, but that most of these activities are not associated with sites for the wheat germ and soybean agglutinins.
Electron microscopical study of rowson‐parr virus infection in balb/c mice
Authors: Michaels L. , Rowson K. E. K. , Bird E. S. 
Published: June 2010

AbstractThe significant electron microscopic changes in the course of Rowson‐Parr virus infection in BALB/c mice are described. In the early splenomegaly there is active folding of cell membranes of reticulum cells of the spleen in germinal centres and red pulp. Type‐C virus particles are seen between the folds, but not budding from these cells. This change is interpreted as the localization of virus antigen prior to specific antibody production. Plasma cells are present in considerable numbers in the red pulp soon after. These changes persist to a lesser degree in the spleen throughout the period when it is of normal size. The cells constituting the lymphoma resemble other murine lymphomas and are also characterized by the frequent appearance of type‐C virus particles budding from their surfaces.Electron microscopy of negatively stained centrifuged plasma was also carried out. In the first 4 days single scattered virus particles of typical murine oncogenic type are present, but these become agglutinated from the 5th day onwards. Perivascular mononuclear cell infiltrates are present in the kidneys after the 30th week. These are composed of plasma cells and reticulum cells with folded membranes, enclosing virus particles.The lymphoma in RPV infection thus develops at the site of and following a prolonged period of immunological reaction to the virus.
Identity of the soluble ebv‐associated antigens of human lymphoid cell lines
Authors: Reedman Beverley M. , Pope J. H. , Moss D. J. 
Published: June 2010

AbstractThe reactions of human sera with antigens prepared from five human lymphoid cell lines were studied by immunodiffusion. Two major precipitation lines occurred with QIMR‐WIL antigens; one (S line) due to a soluble antigen and the other (F line) due to a sedimentable antigen. A close association in human sera of precipitins producing the S line with antibody to Epstein‐Barr virus (EBV) detectable by immunofluorescence (Henle test) and by complement fixation (CF) tests indicated a specific association of the S line with EBV, but the nature of the F line was not clarified. Soluble antigens prepared from five lymphoid cell lines (including Raji) contained at least one common identical heat‐resistant component, defined as the antigen giving the S line. The ease of detection of the S antigen in cell lines by immunodiffusion appeared to be related to the titre of the soluble EBV‐associated CF antigen, and the evidence suggested that the soluble CF and ID antigens were probably identical.
The combined action of rauscher leukemia virus and lactic dehydrogenase virus on mouse lymphatic tissue
Authors: Proffitt Max Rowland , Congdon C. C , Tyndall R. L. 
Published: June 2010

AbstractMice inoculated with animal‐passaged Rauscher leukemia virus contaminated with lactic dehydrogenase virus showed early gross and histological changes in their lymphatic tissues comparable to those in mice inoculated with lactic dehydrogenase virus alone. Some of the changes closely resembled those that have been ascribed to stress, which are mediated by corticosteroid hormones Except for early erythroblast activation, mice inoculated with a pool of animal‐passaged Rauscher leukemia virus derived from cell culture and not contaminated with lactic dehydrogenase virus did not undergo these changes. Most notable were the absence of early lymphocyte destruction in thymus‐dependent areas responsible for cell‐mediated immunity and the lack of significant immunoblast activation and proliferation in lymphoid germinal centers (humoral immune compartment).The presence of lactic dehydrogenase virus in Rauscher leukemia virus pools or its addition to the uncontaminated pool resulted in an enhancement of the “erythro‐blastic reaction” associated with Rauscher disease, as indicated by an increase in spleen weight. There was also prominent diffuse and persisting hyperplasia of germinal center cells (immunoblasts and immunocytes) after lactic dehydrogenase virus was added to the uncontaminated Rauscher virus pool. Furthermore, the presence of the lactic dehydrogenase virus enhanced the immunosuppressive properties of Rauscher leukemia virus.Two possibilities were considered to account for the enhancement of Rauscher disease by lactic dehydrogenase virus. First, by stimulating germinal center hyperplasia, the virus could supply greater numbers of target cells for Rauscher virus replication. Second, the depression of the cell‐mediated immune response by lactic dehydrogenase virus could prevent the inactivation of Rauscher virus particles, or tumor cells by lymphocytes.
Further studies on the mechanism of growth of a transplantable virus‐induced lymphoid tumour of mice
Authors: Croft C. J. 
Published: June 2010

AbstractThe nature of mitotic host cells observed in transplants of a virus‐induced lymphoid tumour of mice has been investigated. Evidence is presented indicating that they are stromal in nature and not tumour cells. Transplants of this tumour into neonatal or adult mice grow only by the proliferation of donor cells, and the cells of secondary tumours found in the spleens of mice bearing subcutaneously transplanted tumours are also derived from the cells inoculated. The role of the virus in the growth of this tumour is compared with that of the Rous sarcoma of chickens.
Properties of a murine sarcoma virus isolated from a tumor arising in an nzw/nzb f1 hybrid mouse. i. isolation and pathology of tumors induced in rodents
Authors: Gazdar Adi F. , Chopra Harish C. , Sarma Padman S. 
Published: June 2010

AbstractA potent sarcoma virus was isolated after in vivo passage of a tumor arising spontaneously in a New Zealand White × New Zealand Black (B/ W) F1 hybrid mouse. Inoculation of the virus into mice, rats, hamsters, and Mastomys resulted in the rapid development of tumors at the sites of inoculation. The tumors induced in mice were sarcomas consisting of spindle cells and many inflammatory cells. Most tumors had a prominent angiomatous component. Tumor regressions occurred in some mice, while other tumors grew progressively, metastasized, and resulted in death. B/ W mice developed splenomegaly 4‐6 weeks after virus inoculation. The normal architecture of their spleens was completely destroyed and replaced by angiomatous tissue, fibrosis, and inflammatory changes. Virus‐induced tumors in hamsters consisted of undifferentiated polygonal cells. Virus‐induced tumors of rats and Mastomys consisted of thin‐walled blood vessels heavily infiltrated with polymorphonuclear leukocytes. Primary virus‐induced tumors in hamsters, rats, and Mastomys did not regress, but some transplanted hamster tumors regressed. Electron microscopy of virus‐induced and transplanted tumors revealed numerous type‐C virus particles morphologically similar to the murine leukemia‐sarcoma viruses. Tumor homogenates contained the group‐specific (gs) antigen of the murine leukemia‐sarcoma viruses.