bluuebunny/crossref_metadata_2025_split huggingface dataset:
Molecular cellular reactions of the respiratory tract to cold stimulus in non-allergic bronchial asthma
Authors: Pirogov A. B. , Prikhodko A. G. , Pirogova N. A. , Perelman J. M. 
Published: June 2024

Introduction. Macrophages, matrix metalloproteinase-9 (MMP-9) and tumor necrosis factor-alpha (TNF-α) make a significant contribution to the pathophysiological mechanisms of development and course of bronchial asthma.Aim. To evaluate the role of macrophages and MMP-9 regulated by TNF-α signaling in the formation of airway response of non-allergic bronchial asthma patients to cold air hyperventilation.Materials and methods. Spirometric indices of forced expiratory flow, cellular composition of sputum, MMP-9 and TNF-α content in exhaled breath condensate (EBC) were measured in 66 patients with asthma before and after bronchoprovocation test with isocapnic hyperventilation with cold (-20°C) air (IHCA) were evaluated.Results. Two groups of patients with presence (group 1) or absence (group 2) of cold airway hyperresponsiveness were formed. High macrophage and neutrophil counts and a significant decrease in the number of epithelial cells in sputum were recorded after the IHCA. Concentrations of TNF-α and MMP-9 in EBC after IHCA decreased to a greater extent in patients of group 2. The content of epitheliocytes in sputum was correlated with FEF50 (r=-0.49, p=0.03), FEF75 (r=-0.45, p=0.047) and MEF25-75 (r=-0.47, p=0.038), and their content after IHCA test with ΔMEF25-75 (Rs=0.31; p=0.018). We found a correlation between baseline MMP-9 content in EBC and ΔMEF25-75 (Rs=-0.59; p=0.042), as well as between MMP-9 level after IHCA and severity of bronchospasm (ΔMEF25-75) in response to IHCA test (Rs=-0.67; p=0.023).Conclusion. In patients with cold airway hyperresponsiveness, uncontrolled course of asthma and more significant bronchial patency disorders are associated with productive-proliferative inflammation involving macrophages, MMP-9 and TNF-α, which contributes to bronchial remodeling.
Leukocyte-platelet aggregates in the pathogenesis of respiratory failure in patients with COVID-19 with varying degrees of oxygen support
Authors: Burdenko T. O. , Fefelova E. V. , Shapovalov K. G. , Tereshkov P. P. , Tsibikov N. N. 
Published: June 2024

Introduction. Thrombo-inflammatory changes in the alveolar-capillary membrane are significant links in the pathogenesis of respiratory failure in COVID-19. This study investigates whether leukocyte-platelet aggregates contribute to its development and, if so, the mechanisms involved.Aim. To examine the quantitative changes in leukocyteplatelet aggregates in patients with COVID-19 receiving different levels of oxygen support.Materials and methods. The study included 134 COVID-19 patients of varying severity and 20 volunteers examined in the pre-pandemic period. The criterion for dividing the studied patients into groups was the ratio of blood oxygen saturation to its inhaled fraction, investigated by pulse oximetry. Three groups were formed depending on the value of the index: in the first (n=48), the SpO2/FiO2 index was above 450%, in the second (n=55) it ranged from 370 to 449%, and in the third (n=51) the index was up to 369%. The enumeration of blood cells, major leukocyte populations, lymphocyte subpopulations, and plateletleukocyte complexes was performed using the CytoFLEX LX flow cytometer (Beckman Coulter, USA).Results. In the third group, there was a decrease in the number of monocytic aggregates (p<0.001) and their subfractions, as well as the number of lymphocyte rosettes (p=0.015), while the number of lymphocytes (p<0.001) and neutrophil interactions (p=0.05) increased in parallel. In the second group, there was a statistically significant decrease in the total number of monocytic aggregates (p=0.038), and in the third, the number of aggregates with classical monocytes (p=0.012).Conclusion. The number of lymphocyte-platelet and monocyte-platelet aggregates decreased in patients with different types of oxygen support, while neutrophil-platelet aggregates increased and correlated with the SpO2/FiO2 ratio.
The role of interleukin 1β and prostaglandin E2 in early pregnancy miscarriage associated with cytomegalovirus infection
Authors: Ishutina N. A. , Dovzhikova I. V. , Dorofienko N. N. 
Published: June 2024

Aim. To investigate the levels of interleukin 1β (IL-1β) and prostaglandin (PG) E2 in peripheral blood and their prognostic significance in predicting pregnancy miscarriage in women with cytomegalovirus (CMV) infection exacerbation.Materials and methods. This case-control study included 98 women in the first trimester of pregnancy (710 weeks), of which 50 women with CMV infection exacerbation (main group) and 48 essentially healthy women (control group). CMV infection was diagnosed by the presence of class M and G antibodies using enzyme-linked immunosorbent assay (ELISA), as well as CMV DNA detected by PCR. The levels of IL-1β and PG E2 in serum of peripheral blood were determined by ELISA using kits from Vector-Best (Novosibirsk, Russia) for IL-1β and Cloud-Clone Corp. (USA) for PG E2.Results. The study found that women in the main group had a significant increase in the level of IL-1β up to 284.20±20.25 pg/mL (p<0.001) compared with the control group (1.49±0.03 pg/mL). Similarly, the level of PG E2 was also higher than that of the control group, amounting to 929.62±38.0 pg/mL (p<0.001) and 1.29±0.08 pg/mL, respectively.Conclusion. The results of the study establish the prognostic role of IL-1β and PG E2 concentrations in the pathogenesis of pregnancy miscarriage in women with exacerbation of CMV infection in the early stages of gestation. High concentrations of IL-1β and PG E2 may indicate the development of pregnancy complications and be used as a nonspecific markerpredictor of the threat of miscarriage during CMV infection exacerbation.
Estrategias para desarrollar inteligencia emocional en estudiantes de décimo grado en IETC Alberto Pumarejo
Authors: Osorio Mendoza Zenith Lucia , Martínez Vargas Karen Margarita 
Published: June 2024

La inteligencia emocional permite el recoger y manejar las emociones, considerando su valor sobre las decisiones en la vida; el ser humano decidía tomando en cuenta solo el consciente intelectual; no obstante, las emociones son importantes en todas las acciones que realiza el ser. Se considera que, la inteligencia emocional es una característica de las personas, y tiene gran relevancia para las personas debido a su gran intervención en los distintos aspectos de la vida. En consecuencia, afecta drásticamente el desarrollo pleno de la colectividad, tanto a nivel social, educativo, cultural y profesional. El método utilizado, fue de tipo Investigación Acción. Esta se llevó a cabo en Malambo, departamento del Atlántico. Los instrumentos utilizados fueron el Diario de Campo para la técnica de la observación y la entrevista semiestructurada. Se identificó la forma en la que se estimulan las competencias socioemocionales en esta institución. planteando que, la educación formal se ha basado en el desarrollo de habilidades y competencias para la academia y la vida laboral, sin estimular el área emocional y afectivo de los estudiantes. Conclusiones, se ha observado que muchos de ellos carecen de las habilidades necesarias para afrontar estas situaciones de manera efectiva.
OWIED System to Facilitate the Entrustment Decision in EPA Implementation
Authors: Al-Moteri Modi 
Published: June 2024

Background:
Entrustable professional activities (EPAs) are gaining attention as an approach for adequate implementation of a competency-based evaluation framework in nursing education. This study sought to develop an Online Web-assessment Interface for Entrustment Decision (OWIED) to facilitate the entrustment decision in EPA implementation.

Method:
A participatory qualitative action research design consisting of two phases was used for this study. The exploration phase was conducted in close collaboration with stakeholders. Following the exploration phase, the primary researcher and a team of subject-matter experts in academic and information technology developed the OWIED system according to the exploration phase results.

Results:
The necessary features that met the expectations of the stakeholders were identified and assisted in developing the OWIED system.

Conclusion:

OWIED may provide a valid tool to track and validate nursing student acquisition of core competencies and assist in making entrustment decisions as students fulfill their training requirements in their academic program.

[
J Nurs Educ
. 2024;63(6):356–365.]
Nursing Students' Perception of Caring for Culturally Diverse Patients: A Hermeneutic Phenomenological Study
Authors: Bozkurt Semiha Asli , Gazarian Priscilla K. 
Published: June 2024

Background:
This study examined the phenomenon of prelicensure nursing students caring for culturally diverse patients.

Method:
Individual interviews were conducted with undergraduate nursing students using a hermeneutic phenomenological approach. Qualitative research experts conducted the interviews, transcribed the data, and followed van Manen's methodology for analysis.

Results:
Eleven nursing students participated in the study. Data were collected from April to August 2022. The average length of the student interviews was 32 minutes. Four themes were identified: (1) communication issues; (2) access to care; (3) nurse background; and (4) trust and respect.

Conclusion:

This study highlights the importance of caring for culturally diverse patients. Policymakers and health care leaders can use the findings to support legislative proposals for enhancing culturally diverse patient safety and health equity. Based on these findings, nurse educators and preceptors can adapt their clinical teaching approaches accordingly, and nurse managers can benefit from the results when hiring new graduate nurses.

[
J Nurs Educ
. 2024;63(6):373–379.]
Interventions to Increase the Diversity of Nursing Programs: An Integrative Review
Authors: McCord Aaron , Otte Julie 
Published: June 2024

Background:
In 2011, the Institute of Medicine's The Future of Nursing: Leading Change, Advancing Health report declared the need to increase diversity in nursing. The National League for Nursing stated that nursing pipeline programs would be essential to create increased diversity. However, no details regarding the definition, construction, or implementation of a nursing pipeline were available within the position statement.

Method:
An inclusive integrative literature review was conducted. The aim was to examine interventions targeted toward increasing diversity in nursing education programs.

Results:
Twelve articles were included in the review. Similar interventions were used by nursing education programs; these included strategies to raise awareness about nursing to prospective students, preen-try preparation, holistic admissions, scholarships, tutoring, mentoring, and targeted advising.

Conclusion:

Evidence indicates interventions aimed at the retention of at-risk individuals are successful. Additional research is needed to develop effective recruitment strategies for diverse populations.

[
J Nurs Educ
. 2024;63(6):387–393.]
Knowledge, attitude and practice of paramedics towards health care waste in Port Harcourt, Nigeria
Authors: Abah Austin Edache , Ogbonna Divine Adaeze 
Published: June 2024

Healthcare waste causes environmental and public health hazards. This study assessed the Knowledge, Attitude, and Practices of healthcare workers in Paramedical Centers in Port Harcourt Metropolis. A purposive sampling technique was employed. Data were collected using a well-structured questionnaire and on-the-spot observation. A total of 77 healthcare centers were sampled. Frequency of types of healthcare; pharmacy (33.8%), medical laboratory (28.6%), ‘chemist’ (27.3%), and drug store (10.3%). Females dominated (64.9%) against the males (35.1%). These facilities do not employ waste handlers (0%) to manage their waste. Majority, 75.3% had a first degree, 13.0% higher degree, and 11.7% had O' level certificate. All the healthcare centers (100%) produce biomedical waste, and 52.3% produce hazardous waste, 37.7% are aware of the correct guidelines for the disposal of biomedical wastes and only 35.1% of facilities practiced good waste disposal, 57.1% had no idea the kind of waste disposal practice and still dispose of their waste on road medians. Only 5.2% have undergone training. Only 37.7% segregate their wastes. In conclusion, the attitude and practice of the Healthcare workers towards waste in the area is low. It is recommended that advocacy be intensified as no one is safe until all of us are safe.
Evaluating the prevalence of early weaning of children and its determinants among maternal attendees at Remera Health Center, Kigali, Rwanda, 2023: a cross-sectional study
Authors: Gahima Ivan , Niwemahoro Consolee , Turikumana Elie , Iragena Zawadi Mireille , Cyuzuzo Odah , Ndayishimiye Manasseh , Muragire Roger , Wabwire Paul Francis , Uwase Melissa , Byiringiro Charite , Bidemi Okesina Kazeem , Akorede Gbadamosi Mojeed , Ayodeji Okesina A. 
Published: June 2024

INTRODUCTION: While breast milk is vital in fostering infant growth and diminishing the risk of illnesses, global exclusive breastfeeding rates stand at 45.7%. Early weaning remains a persistent issue, particularly in low- and middle-income countries. Consequently, this study was formulated to evaluate the prevalence of early weaning and its influencing factors among mothers seeking care at the Remera Medicalized Health Center.METHOD: A cross-sectional investigation encompassed 370 randomly chosen breastfeeding mothers who underwent data collection via a structured questionnaire.RESULTS: In the cohort of 370 participants, this study unveiled that 97.8% (n=362) concurred on the importance of exclusive breastfeeding, yet only 73.8% (n=263) adhered to this practice. Notably, 26% (n=97) initiated early weaning. Breastfeeding challenges were reported by 51.6% (n=191) of participants, with 21.6% (n=80) facing issues of low milk supply and 8.1% (n=30) experiencing child refusal to breastfeed. Furthermore, 90.8% (n=336) demonstrated awareness of the consequences of early weaning, and 33.5% (n=124) acknowledged agreement with all the potential repercussions. Among mothers who practiced early weaning, 29.9% (n=29) did so at 4 months, 25.9% (n=25) at 5 months, 21.6% (n=21) at 3 months, and 11.3% (n=11) at 1 and 2 months. Reasons for early weaning included tight schedules (43.3%, n=42) and the baby's hunger (36.1%, n=35). Additionally, 77.6% (n=287) concurred that the choice of early weaning should ultimately be the mother's decision.CONCLUSION: The primary factors influencing mothers' adoption of early weaning were predominantly their demanding schedules, which encompassed both work and studies, as well as the baby's heightened need for food owing to hunger.
Deskriptif Literatur Review: Pendampingan Pasien Kanker Payudara pada Perawatan Paliatif
Authors: Rasman Siti Nurjanah , Trustisari Hastin 
Published: June 2024

Kanker payudara menempati urutan pertama terkait jumlah kanker terbanyak di Indonesia serta menjadi salah satu penyumbang kematian pertama akibat kanker. Tingginya angka kanker payudara di Indonesia menjadi prioritas penanganan oleh pemerintah. Penelitian ini bertujuan memberikan gambaran terkait pendampingan perawatan paliatif pada pasien kanker payudara. Pada penelitian ini menggunakan metode literatur review yaitu deksriptif. Pendamping dapat memberikan social support kepada pasien dengan mendampingi pasien dan keluarganya, serta meningkatkan kesadaran akan pentingnya keluarga pasien. Bahwasanya pendampingan merupakan upaya dalam pemberian bantuan kepada individu yang membutuhkan guna menguatkan, mendukung, dan membantu menyelesaikan permasalahan individu dari segi sosial dan psikologis individu agar individu tersebut dapat menjalankan tugas dan fungsinya sebagai individu yang dimilikinya. Pasien kanker masih jarang diberikan pendampingan, peneliti hanya berfokus pada peningkatan kualitas hidup pasien kanker, perawatan paliatif berbasis kesehatan. Perlu adanya pendampingan bagi pasien kanker pada perawatan paliatif.
Sosialisasi Bahaya Narkotika Pada Dayah Darul Aman Desa Lubok Sukon Kabupaten Aceh Besar
Authors: Saputra Jummaidi Saputra , Nasution Anhar , Iqbal Muhammad , Yovano Gilbert Sinurat Ignatius 
Published: June 2024

Bahaya narkotika di kalangan remaja memang perlu mendapatkan perhatian yang serius. Sebagai generasi yang meneruskan cita-cita bangsa sudah sepatutnya kita membekali para remaja dengan moralitas yang baik. Adanya berbagai macam faktor yang menyebabkan mereka terjerumus pada hal-hal yang menyimpang tersebut tentu meresahkan banyak orang tua dan juga masyarakat secara umum. Peran dayah, agama, keluarga disini tentu sangat penting guna memberikan pemahaman terhadap remaja terhadap dampak-dampak yang dihasilkan dari perilaku melanggar ataupun menyimpang yang dilakukan oleh kaum remaja. Dengan mengadakan sosialisasi di Dayah Darul Aman diharapkan agar para santri dapat membuka wawasan berpikir dan mencermati makna kenakalan remaja dan bahaya narkotika, sehingga mereka bias lebih berhati-hati dalam bergaul dalam lingkungan masyarakat.
Faktor-Faktor yang Mempengaruhi Motivasi Petani Milenial dalam Berwirausaha di Bidang Pertanian di Kabupaten Lampung Selatan
Authors: Gohan Octora Manurung  , F. Trisakti Haryadi  , Partini Partini  
Published: June 2024

Generasi milenial yang bekerja di bidang pertanian punya potensi besar dalam mengembangkan jiwa wirausaha pertanian sebagai petani milenial. Pilihan hidup petani milenial untuk berwirausaha di bidang pertanian perlu dianalisis bagaimana lingkungan sosial, peran agen perubahan, pemanfaatan teknologi digital mempengaruhi persepsi kaum milenial di bidang pertanian. Penelitian ini dilakukan di Kabupaten Lampung Selatan yang merupakan daerah sentra produksi pertanian di Provinsi Lampung. Karakter petani milenial yang unik adaptif dengan teknologi informasi dan komunikasi juga memiliki berbagai kelemahan dan kelebihannya untuk mau berwirausaha pertanian. Faktor dari internal dan eksternal mendorong motivasi petani milenial untuk berwirausaha di bidang pertanian. Tujuan penelitian untuk menganalisis faktor peran agen perubahan, pemanfaatan teknologi TIK, lingkungan sosial dan persepsi terhadap motivasi berwirausaha di bidang pertanian. Pengambilan sampel penelitian dilakukan di Kabupaten Lampung Selatan dengan cara cluster random sampling, 3 klaster zonasi, 6 kecamatan dengan total sampel 125 orang. Alat analisis statistik dilakukan dengan menggunakan Path analisis menggunakan program Statistik IBM Amos 22. Motivasi dipengaruhi secara langsung oleh variabel persepsi (p < 0,01) dan pemanfaatan teknologi (p < 0,02). Variabel pemanfaatan teknologi TIK dan lingkungan sosial dapat berpengaruh secara tidak langsung terhadap motivasi melalui persepsi. Agen perubahan mempengaruhi lingkungan sosial dan pemanfaatan teknologi TIK yang akan mempengaruhi secara tidak langsung kepada motivasi petani melalui persepsi.
SOCIAL TIME AND HISTORICAL MEMORY: SYSTEMIC CORRELATIONS IN THE CULTURAL SPACE OF MODERN RUSSIA
Authors: СНЕЖКО Г.Е. 
Published: June 2024

Статья посвящена рассмотрению коррелятивных связей, в которые вступают социальное время и историческая память. Современная российская действительность вносит свои коррективы в функционирование социальной и исторической памяти, при этом необратимость развития общества как одной из трансформаций материи и общественного сознания диктует и наличие связей с социальным временем. Историческая память характеризуется социальной дифференциацией и лабильностью: идеальная реальность, которую такая память продуцирует, подвержена постоянному обновлению, но в то же время она значима и подлинна, как и событийная реальность. Автор статьи подчеркивает важность этих основополагающих моментов для социологии: в предметном поле возникает возможность абстрагироваться от теоретизирования в сфере взаимодействия субъективного и объективного времени и моделировать социальное время в аспектах личного жизненного пути и путей развития нации. Делается вывод о том, что в культурном пространстве современной России назрела необходимость создания равновесия между социальной и исторической памятью с целью гармонизации функционирования индивида и общества в параметрах социального времени.
The paper considers the correlative connections between social time and historical memory. Modern Russian reality makes its own adjustments to the functioning of social and historical memory, while the irreversibility of the development of society as one of the transformations of matter and social consciousness also dictates the presence of connections with social time. Historical memory is characterized by social differentiation and lability: the ideal reality that such memory produces is subject to constant updating, but at the same time it is significant and authentic, like eventual reality. The author comes to the conclusion about the importance of these fundamental points for sociology: it becomes possible to abstract from theorizing in the sphere of interaction of subjective and objective time and model social time in aspects of a personal life path and the paths of development of a nation. In the cultural space of modern Russia, there is a need to create a balance between social and historical memory in order to harmonize the functioning of the individual and society in the parameters of social time.
Preface: 3rd International Conference on Biochemical Engineering and Environmentally Friendly Material (BEEFM 2024)
Authors: Gunther Miranda , Pan Disheng 
Published: June 2024

2024 3rd International Conference on Biochemical Engineering and Environmentally Friendly Material (BEEFM 2024) was successfully held online during April 20-21, 2024 in Budapest, Hungary. The conference invited scholars and experts in the fields of chemistry, biology, environmental engineering and materials application from various universities and institutes, to participate in the review and guidance of this conference. The conference focuses on the latest research fields, and provides an international cooperation and exchange platform for experts, scholars, and business managers in these fields.
The aim of BEEFM 2024 is to share the research achievements, discuss the key challenges and research directions of the development, and jointly promote the industrialization cooperation and continuous innovation of international academic achievements. This collection of proceedings compiles oral and paper presentations submitted by the authors and scrutinized by the special committee.
The opening ceremony was held in the main session and a speech was delivered by the invited speaker. After the main session, we divided the participants into three sub-sessions. Each author spoke for about 15-20 minutes on detailed material in the slides, with the same amount of time set aside for questions and discussion. The format of questioning and discussion was that after each author's introduction, the conference chairman and committee members asked and answered questions. At least one attendee could ask questions that will be answered by the speaker.
BEEFM 2024 had brought together many excellent works, latest ideas, and concepts. New ideas have been provided in the fields of chemistry, biology, environmental engineering, and materials application. Look forward to meeting again next year.
BEEFM 2024 Conference Scientific Committees
Budapest, Hungary