bluuebunny/crossref_metadata_2025_split huggingface dataset:
From crystal to crustal: petrofabric-derived seismic modelling of regional tectonics
Authors: Lloyd G. E. , Halliday J. M. , Butler R. W. H. , Casey M. , Kendall J.-M. , Wookey J. , Mainprice D. 
Published: November 2011

Abstract
The Nanga Parbat Massif (NPM), Pakistan Himalaya, is an exhumed tract of Indian continental crust and represents an area of active crustal thickening and exhumation. While the most effective way to study the NPM at depth is through seismic imaging, interpretation depends upon knowledge of the seismic properties of the rocks. Gneissic, ‘mylonitic’ and cataclastic rocks emplaced at the surface were sampled as proxies for lithologies and fabrics currently accommodating deformation at depth. Mineral crystallographic preferred orientations (CPO) were measured via scanning electron microscope (SEM)/electron backscatter diffraction (EBSD), from which three-dimensional (3D) elastic constants, seismic velocities and anisotropies were predicted. Micas make the main contribution to sample anisotropy. Background gneisses have highest anisotropy (up to 10.4% shear-wave splitting, AVs) compared with samples exhibiting localized deformations (e.g. ‘mylonite’, 4.7% AVs; cataclasite, 1% AVs). Thus, mylonitic shear zones may be characterized by regions of low anisotropy compared to their wall rocks. CPO-derived sample elastic constants were used to construct seismic models of NPM tectonics, through which P-, S- and converted waves were ray-traced. Foliation orientation has dramatic effects on these waves. The seismic models suggest dominantly pure-shear tectonics for the NPM involving horizontal compression and vertical stretching, modified by localized ductile and brittle (‘simple’) shear deformations.
Obliteration of olivine crystallographic preferred orientation patterns in subduction-related antigorite-bearing mantle peridotite: an example from the Higashi–Akaishi body, SW Japan
Authors: Wallis S. R. , Kobayashi H. , Nishii A. , Mizukami T. , Seto Y. 
Published: November 2011

Abstract

Large parts of the mantle wedge near subduction boundaries are likely to be hydrated and contain antigorite. This mineral is acoustically highly anisotropic and potentially has a strong influence on seismic properties of the wedge. The Higashi–Akaishi body of SW Japan is an exhumed sliver of partially serpentinized forearc mantle, ideal for studying the effects of antigorite on the development of tectonic fabrics in the mantle. Samples with less than 1% antigorite show strong B-type olivine crystallographic preferred orientation (CPO) patterns. In contrast, samples with >10% antigorite deformed during the same tectonic event show much weaker olivine CPO patterns lacking the flow-normal
a
-axis concentration. These microstructural data suggest that the development of antigorite during deformation weakens olivine CPO due to phase boundary slip and associated rigid-body rotation of olivine grains. Antigorite and similar sheet silicates are likely to be present to some extent in the mantle wedge of all convergent margins. Our results suggest that even if this amount is only a few percent, strong olivine CPO is unlikely to develop and any pre-existing CPO is likely to be destroyed. Under these conditions, olivine CPO is unlikely to contribute significantly to seismic anisotropy in the mantle wedge.
Crystal fabric development and slip systems in a quartz mylonite: an approach via transmission electron microscopy and viscoplastic self-consistent modelling
Authors: Morales Luiz F. G. , Mainprice David , Lloyd Geoffrey E. , Law Richard D. 
Published: November 2011

Abstract

We have applied transmission electron microscopy (TEM) analyses coupled with viscoplastic self-consistent (VPSC) numerical modelling to identify the active slip systems and to better understand the crystal preferred orientation (CPO) development of the Torridon quartz mylonite (NW Scotland). TEM analyses showed evidence of activation of 1/3〈
a
〉{π′}, 1/3〈
a
〉{
z
} and possible 〈
a
〉(
c
) slip systems, as well as dislocation climb and dynamic recrystallization. All the CPOs generated by VPSC models share common characteristics with the Torridon quartz mylonite, but only Models 2 and 3 reproduce the [
c
]-axes maxima at low angle (<20°) to the foliation pole along the
YZ
plane, as observed in the mylonite. In Model 2, this concentration only occurs at γ≥2.6, whereas in Model 3 this maxima occurs at lower shear strains. The models that start with a previous preferred orientation acquire very strong CPOs after small-imposed strains, followed by the rapid rotation of the fabric in relation to the new imposed finite strain axes. The combined activation of 〈
a
〉{π′}, 〈
a
〉{
z
} and possibly 〈
a
〉(
c
) slip systems, as demonstrated by TEM analyses, suggests that the VPSC model that best predicts CPO development in the Torridon quartz mylonite is Model 2, where the critical resolved shear stress (CRSS) of 〈
a
〉{π/π′} is assumed to be slightly stronger than 〈
a
〉(
c
).
Identification of Tumorigenic Cells in KrasG12D-Induced Lung Adenocarcinoma
Authors: Cho Huan-Chieh , Lai Chao-Yang , Shao Li-En , Yu John 
Published: November 2011

Abstract
We established an inducible KrasG12D-driven lung adenocarcinoma in CCSP-rtTA/TetO-Cre/LSL-KrasG12D mice that enable pursuits of the cellular and molecular processes involved in Kras-induced tumorigenesis. To investigate the cellular origin of this cancer, we first report a strategy using fluorescence-activated cell sorting fractionation that could highly enrich bronchiolar Clara and alveolar type II cells, respectively. The EpCAM+MHCII− cells (bronchiolar origin) were more enriched with tumorigenic cells in generating secondary tumors than EpCAM+MHCII+ cells (alveolar origin) in primary tumors that had been already initiated with oncogenic Kras activation. In addition, secondary tumors derived from EpCAM+MHCII− cells showed diversity of tumor locations compared with those derived from EpCAM+MHCII+ cells. In the alveolar region, secondary tumors from EpCAM+MHCII− cells expressed not only bronchiolar epithelial marker, panCK, but also differentiation marker, proSPC, consistent with the notion that cancer-initiating cells display not only the abilities for self-renewal but also the features of differentiation to generate heterogeneous tumors with phenotypic diversity. Furthermore, high level of ERK1/2 activation and colony-forming ability as well as lack of Sprouty-2 expression were also observed in EpCAM+MHCII− cells. Therefore, these results suggest that bronchiolar Clara cells are the origin of cells and tumorigenesis for KrasG12D-induced neoplasia in the lungs. Cancer Res; 71(23); 7250–8. ©2011 AACR.
Molecular Characterization of Neuroendocrine Prostate Cancer and Identification of New Drug Targets
Authors: Beltran Himisha , Rickman David S. , Park Kyung , Chae Sung Suk , Sboner Andrea , MacDonald Theresa Y. , Wang Yuwei , Sheikh Karen L. , Terry Stéphane , Tagawa Scott T. , Dhir Rajiv , Nelson Joel B. , de la Taille Alexandre , Allory Yves , Gerstein Mark B. , Perner Sven , Pienta Kenneth J. , Chinnaiyan Arul M. , Wang Yuzhuo , Collins Colin C. , Gleave Martin E. , Demichelis Francesca , Nanus David M. , Rubin Mark A. 
Published: November 2011

Abstract
Neuroendocrine prostate cancer (NEPC) is an aggressive subtype of prostate cancer that most commonly evolves from preexisting prostate adenocarcinoma (PCA). Using next-generation RNA sequencing and oligonucleotide arrays, we profiled 7 NEPC, 30 PCA, and 5 benign prostate tissue (BEN) samples and validated findings in tumors from a large cohort of patients (37 with NEPC, 169 with PCA, and 22 with BEN) using immunohistochemistry and FISH. We discovered significant overexpression and gene amplification of AURKA and MYCN in 40% of NEPC and 5% of PCA tumors, respectively, and evidence that they cooperate to induce a neuroendocrine phenotype in prostate cells. There was dramatic and enhanced sensitivity of NEPC (and MYCN overexpressing PCA) to Aurora kinase inhibitor therapy both in vitro and in vivo, with complete suppression of neuroendocrine marker expression following treatment. We propose that alterations in Aurora kinase A and N-myc are involved in the development of NEPC and that future clinical trials will help determine the efficacy of Aurora kinase inhibitor therapy.
Significance: We report on the largest in-depth molecular analysis of NEPC and provide new insight into molecular events involved in the progression of prostate cancer. Cancer Discovery; 1(6); 487–95. ©2011 AACR.
Read the Commentary on this article by Aparicio et al., p. 466
This article is highlighted in the In This Issue feature, p. 457
Understanding the Lethal Variant of Prostate Cancer: Power of Examining Extremes
Authors: Aparicio Ana , Logothetis Christopher J. , Maity Sankar N. 
Published: November 2011

AbstractSmall cell prostate carcinoma is a lethal variant of castration-resistant prostate cancer. Beltran and colleagues identified overexpression and amplification of both aurora kinase A (AURKA) and the MYCN proto-oncogene in the small cell prostate carcinomas and propose Aurora kinase A as a potential therapeutic target in this disease subset. Cancer Discovery; 1(6); 466–68. ©2011 AACR.Commentary on Beltran et al., p. 487.
HER2 Signaling and Resistance to the Anti-EGFR Monoclonal Antibody Cetuximab: A Further Step toward Personalized Medicine for Patients with Colorectal Cancer
Authors: Ciardiello Fortunato , Normanno Nicola 
Published: November 2011

Abstract
Primary and acquired resistance to anti-epidermal growth factor receptor (EGFR) drugs are clinically relevant problems in patients with metastatic colorectal carcinoma. A complex network of molecular alterations is involved in this phenomenon. Bertotti et al. report the development of serially transplantable groups of tumor xenografts in immune-deficient mice from patient-derived, genetically characterized metastatic colorectal carcinoma samples. These experimental models (“xenopatients”) might represent a novel approach to discover and characterize the mechanisms of resistance to anti-EGFR therapy and other molecularly targeted therapies in metastatic colorectal carcinoma. In this respect, Bertotti et al. were able to identify HER2 gene amplification as one such mechanism of resistance to anti-EGFR therapy. Cancer Discovery; 1(6); 472–74. ©2011 AACR.
Commentary on Bertotti et al., p. 508.
Study of the Impact of Summer Monsoon Circulation on Spatial Distribution of Aerosols in East Asia Based on Numerical Simulations
Authors: Yan Libin , Liu Xiaodong , Yang Ping , Yin Zhi-Yong , North Gerald R. 
Published: November 2011

AbstractThe regional coupled climate–chemistry/aerosol model (RegCM3) is used to investigate the difference in the spatial distribution of aerosol optical depth (AOD) between a strong summer monsoon year (SSMY; July 2003) and a weak summer monsoon year (WSMY; July 2002) under the actual- and same-emission scenarios. It is shown that the intensity of the Asian summer monsoon is primarily responsible for the AOD spatial distribution anomaly in midsummer over East Asia. Specifically, the AOD over southern China, upwind of the Asian summer monsoon, is greater in WSMY than in SSMY, but the opposite is observed for the AOD downwind over northern China and the Korean Peninsula. The AOD spatial distribution patterns simulated on the basis of the actual emission inventories for the SSMY and WSMY do not substantially differ from their counterparts that are based on the same emission inventory, confirming that the monsoon circulation, rather than local emissions or dry and wet deposition processes, is the predominant factor determining the regional AOD distribution. These modeling results are consistent with the analyses based on the Moderate Resolution Imaging Spectroradiometer (MODIS) products, NCAR–Department of Energy wind fields, and air parcel movements according to the 7-day trajectories of air parcels determined by the Hybrid Single-Particle Lagrangian Integrated Trajectory model.
Hail in Northeast Italy: Climatology and Bivariate Analysis with the Sounding-Derived Indices
Authors: Manzato Agostino 
Published: November 2011

AbstractIn this work the hailpad data collected during the April–September period of the years 1992–2009 by a network of approximately 360 stations on the plain of the Friuli Venezia Giulia region (northeast Italy) were analyzed. The frequency distribution of the hail cases is studied for the different years, for the yearday, and for the time of day, considering four 6-h-long periods of the day. Hail is found to be more frequent during the 1100–2300 UTC time interval and in the months of June and July even though during the 18 years analyzed there does not seem to be a defined trend in hail probability. The spatial distribution shows a maximum of probability along the foothills in particular in the northwest. In the middle of this area there is also the Udine–Campoformido radiosounding station, which performed four soundings per day. Each case (6-h-long period) is then associated with the 52 indices derived from the sounding launched at the beginning of that period. These sounding-derived indices are not all statistically independent, as found by looking at their correlation matrix and aggregating the most-correlated indices in three groups. A diagnostic bivariate analysis between each index and the hit hailpads in 6 h was done as a preliminary attempt to evaluate the utility of these indices for forecasting hail. It is found that some measures of instability (like updraft, hail diameter, and lifted index) seem to have more skill than the other indices when classifying the hail-event occurrence. When estimating the number of hit hailpads, the best correlation is obtained by the indices belonging to the “lifted index family.”
On the Use of Dual-Polarized C-Band Radar for Operational Rainfall Retrieval in Mountainous Areas
Authors: Vulpiani Gianfranco , Montopoli Mario , Passeri Luca Delli , Gioia Antonio G. , Giordano Pietro , Marzano Frank S. 
Published: November 2011

AbstractRadar-rainfall estimation is a complex process that involves several error sources, some of which are related to the environmental context. The presence of orographic obstacles heavily affects the quality of the retrieved radar products. In relatively flat terrain conditions, dual-polarization capability has been proven either to increase the data quality or to improve the rainfall estimate. The potential benefit of using polarimetric techniques for precipitation retrieval is evaluated here using data coming from two radar systems operating in Italy under complex-orography conditions. The analysis outlines encouraging results that might open new scenarios for operational applications. Indeed, the applied rainfall algorithm employing specific differential phase mostly outperformed the examined reflectivity-based retrieval techniques except for the analyzed winter storm. In the latter case, the likely contamination by frozen or melting snow tended to degrade the performance of the examined Kdp-based rainfall algorithms.
Simulated Climate and Climate Change in the GFDL CM2.5 High-Resolution Coupled Climate Model
Authors: Delworth Thomas L. , Rosati Anthony , Anderson Whit , Adcroft Alistair J. , Balaji V. , Benson Rusty , Dixon Keith , Griffies Stephen M. , Lee Hyun-Chul , Pacanowski Ronald C. , Vecchi Gabriel A. , Wittenberg Andrew T. , Zeng Fanrong , Zhang Rong 
Published: November 2011

Abstract
The authors present results for simulated climate and climate change from a newly developed high-resolution global climate model [Geophysical Fluid Dynamics Laboratory Climate Model version 2.5 (GFDL CM2.5)]. The GFDL CM2.5 has an atmospheric resolution of approximately 50 km in the horizontal, with 32 vertical levels. The horizontal resolution in the ocean ranges from 28 km in the tropics to 8 km at high latitudes, with 50 vertical levels. This resolution allows the explicit simulation of some mesoscale eddies in the ocean, particularly at lower latitudes.
Analyses are presented based on the output of a 280-yr control simulation; also presented are results based on a 140-yr simulation in which atmospheric CO2 increases at 1% yr−1 until doubling after 70 yr.
Results are compared to GFDL CM2.1, which has somewhat similar physics but a coarser resolution. The simulated climate in CM2.5 shows marked improvement over many regions, especially the tropics, including a reduction in the double ITCZ and an improved simulation of ENSO. Regional precipitation features are much improved. The Indian monsoon and Amazonian rainfall are also substantially more realistic in CM2.5.
The response of CM2.5 to a doubling of atmospheric CO2 has many features in common with CM2.1, with some notable differences. For example, rainfall changes over the Mediterranean appear to be tightly linked to topography in CM2.5, in contrast to CM2.1 where the response is more spatially homogeneous. In addition, in CM2.5 the near-surface ocean warms substantially in the high latitudes of the Southern Ocean, in contrast to simulations using CM2.1.
An Examination of Climate Change on Extreme Heat Events and Climate–Mortality Relationships in Large U.S. Cities
Authors: Greene Scott , Kalkstein Laurence S. , Mills David M. , Samenow Jason 
Published: November 2011

Abstract
This study examines the impact of a changing climate on heat-related mortality in 40 large cities in the United States. A synoptic climatological procedure, the spatial synoptic classification, is used to evaluate present climate–mortality relationships and project how potential climate changes might affect these values. Specifically, the synoptic classification is combined with downscaled future climate projections for the decadal periods of 2020–29, 2045–55, and 2090–99 from a coupled atmospheric–oceanic general circulation model. The results show an increase in excessive heat event (EHE) days and increased heat-attributable mortality across the study cities with the most pronounced increases projected to occur in the Southeast and Northeast. This increase becomes more dramatic toward the end of the twenty-first century as the anticipated impact of climate change intensifies. The health impact associated with different emissions scenarios is also examined. These results suggest that a “business as usual” approach to greenhouse gas emissions mitigation could result in twice as many heat-related deaths by the end of the century than a lower emissions scenario. Finally, a comparison of future estimates of heat-related mortality during EHEs is presented using algorithms developed during two different, although overlapping, time periods, one that includes some recent large-scale significant EHE intervention strategies (1975–2004), and one without (1975–95). The results suggest these public health responses can significantly decrease heat-related mortality.
Immediate effects of electrical stimulation combined with passive locomotion-like movement on gait velocity and spasticity in persons with hemiparetic stroke: a randomized controlled study
Authors: Yamaguchi Tomofumi , Tanabe Shigeo , Muraoka Yoshihiro , Masakado Yoshihisa , Kimura Akio , Tsuji Tetsuya , Liu Meigen 
Published: November 2011

Objective: Research to examine the immediate effects of electrical stimulation combined with passive locomotion-like movement on gait velocity and spasticity. Design: A single-masked, randomized controlled trial design. Subjects: Twenty-seven stroke inpatients in subacute phase (ischemic n=16, hemorrhagic n=11). Interventions: A novel approach using electrical stimulation combined with passive locomotion-like movement. Main measures: We assessed the maximum gait speed and modified Ashworth scale before and 20 minutes after the interventions. Results: The gait velocity of the electrical stimulation combined with passive locomotion-like movement group showed the increase form 0.68±0.28 (mean±SD, unit: m) to 0.76±0.32 after the intervention. Both the electrical stimulation group and passive locomotion-like movement group also showed increases after the interventions (from 0.76±0.37 to 0.79±0.40, from 0.74±0.35 to 0.77±0.36, respectively). The gait velocity of the electrical stimulation combined with passive locomotion-like movement group differed significantly from those of the other groups (electrical stimulation combined with passive locomotion-like movement versus electrical stimulation: P=0.049, electrical stimulation combined with passive locomotion-like movement versus passive locomotion-like movement: P=0.025). Although there was no statistically significant difference in the modified Ashworth scale among the three groups, six of the nine subjects (66.6%) in the electrical stimulation combined with passive locomotion-like movement group showed improvement in the modified Ashworth scale score, while only three of the nine subjects (33.3%) in the electrical stimulation group and two of the nine subjects (22.2%) improved in the passive locomotion-like movement group. Conclusion: These findings suggest electrical stimulation combined with passive locomotion-like movement could improve gait velocity in stroke patients.
Discrepancies in glomerular and tubulointerstitial/vascular immune complex IgG subclasses in lupus nephritis
Authors: Satoskar AA , Brodsky SV , Nadasdy G , Bott C , Rovin B , Hebert L , Nadasdy T 
Published: November 2011

Background and objectives: Lupus nephritis is characterized by glomerular and extraglomerular immune complex deposition in the kidney. It is unclear whether the same circulating immune complexes deposit in the glomeruli and in extraglomerular structures, or whether they are pathogenetically different. Differences in the IgG subclass composition may point towards different pathways in the formation of glomerular and extraglomerular immune complexes. Therefore we investigated IgG subclass distribution in the immune complex deposits at these anatomic sites. Design: A total of 84 biopsies diagnosed as lupus nephritis and classified according to the International Society of Nephrology/Renal Pathology Society (ISN/RPS) 2003 classification, were examined by direct immunofluorescence staining for IgG subclasses. The IgG subclass composition in the glomerular, tubular basement membrane (TBM) and vascular wall deposits was compared. We also correlated the presence/absence of interstitial inflammation and IgG subclasses in the TBM and vascular deposits. Lastly, we looked for correlation between staining for IgG subclasses and complement C1q and C3 staining. Results: IgG staining was present in the TBM in 52/84 biopsies, and in the vascular walls in 40/84 biopsies. IgG subclass distribution was discrepant between glomerular and TBM deposits in 36/52 biopsies, and between glomerular and vascular deposits in 27/40 biopsies. Interstitial inflammation did not correlate with the presence of IgG staining or distribution of IgG subclasses in the TBM. Interstitial inflammation was more common in biopsies of African–American patients than Caucasian patients. The IgG subclass staining correlated with C1q staining in all the three compartments. Conclusions: The antibody composition of the glomerular and extraglomerular immune complex deposits appear to differ from each other. They may not represent the same preformed immune complexes from the circulation. It is likely that their pathogenesis and site of formation are different.