bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hepatic Cirrhosis with Esophageal Varices: A Case Report
Authors: Minanti Nanda Anessa , Yusri Dianne Jurnalis  
Published: April 2024

Background: In adults, portal hypertension is generally caused by hepatic cirrhosis, whereas in children it is more commonly caused by extrahepatic abnormalities with normal liver function. Portal hypertension causes hemodynamic abnormalities. Gastrointestinal bleeding is the most severe clinical manifestation of portal hypertension in both children and adults. Pathogenetically, increased pressure in the portal vein can be caused by increased vascular resistance and increased portal blood flow. The site of obstruction can be prehepatic (portal vein obstruction), intrahepatic (presinusoidal: eg congenital hepatic fibrosis; para sinusoidal: cirrhosis, hepatotoxic drug therapy, vitamin A hepatotoxicity; post sinusoidal: venocclusive disease) and/or post hepatic (Budd-Chiari syndrome, constrictive pericarditis).
Case presentation: The study reports the results of observations of a case of a boy, FAA, aged 12 years and 2 months who came to the emergency room at Dr. M. Djamil General Hospital Padang with the main complaint of hematemesis and splenomegaly from physical examination. Non cirrhotic portal fibrosis is a cause that is not uncommon in the population in the early second decade of life. Some children with non-cirrhotic portal fibrosis as adults can end up with end stage liver disease.
Conclusion: Patients with noncirrhotic or cirrhotic portal hypertension can be assessed using the Child Pugh instrument as an instrument that is still used to determine the survival rate if patients with portal hypertension.
Modified Buck Boost DC-DC Converter with Hyeteresis Band on Ocean Wave Emulator
Authors: Purnata Hendi , Hera Susanti  , Sugeng Dwi Riyanto  , Agus Santoso  
Published: April 2024

Indonesia has the potential of sea wave energy with the second largest coastline having a density of up to 20 kW / m2. Currently, the use of sea wave technology is still at the prototype stage, with several weaknesses such as erratic sea waves, tides and ocean currents so that they can affect the power generated in ocean wave energy. The results of ocean wave energy in mechanical arrays cannot be utilized because of erratic waves. The higher the wave, the greater the power generated and vice versa. If this problem is not resolved, it can cause unstable power output and cause damage to electronic equipment. The solution to this problem is to modify the DC-DC buck boost converter circuit using the Hyeteresis band method, which limits voltage surges below or above to produce the desired voltage in order to maintain constant power and as energy for storage in the storage system. The result of this study is that the performance of DC generators in producing voltage is greatly influenced by speed. At low speeds, the voltage produced by the generator is still too low to charge the battery or in other words cannot be in a perfect charging position, while at maximum speed it produces voltage with Achieve a level sufficient for battery charging. Therefore, control and adjustment of generator speed is key in maximizing battery charging efficiency using a buck-boost converter.
PHYSICS VISUAL AUDIO MODULE DEVELOPMENT FOR VISUAL AUDITORY LEARNING STYLE : A FEASIBILITY TEST
Authors: Wulan Safitri Nur Alsa , Afifah Salwa Rihhadatul , Setiaji Bayu 
Published: April 2024

Adanya kendala dalam mengajarkan dan memahami materi fisika yang bersifat abstrak, serta adanya panduan pembelajaran dan cara mengajar guru yang tidak sesuai dengan gaya belajar siswa menjadi masalah utama yang dikaji dalam penelitian ini. Penelitian ini dilakukan dengan tujuan mengembangkan modul visual auditori dengan materi optika pemantulan dan pembiasaan yang layak untuk menyesuaikan gaya belajar siswa sehingga dapat meningkatkan prestasi belajar siswa. Metode yang digunakan dalam penelitian ini adalah metode pengembangan dengan desain penelitian model 4-D direduksi menjadi 3-D. Data diambil dengan menggunakan angket uji kelayakan. Teknis analisis data kelayakan dikembangkan dengan menggunakan model Mardapi. Pada angket uji kelayakan ini terdiri dari 11 pertanyaan dengan 3 indikator. Penguji dalam penelitian ini merupakan 40 mahasiswa pendidikan fisika dan fisika murni. Hasil penelitian menunjukkan bahwa Physics Visual Audio Module sangat layak digunakan sebagai panduan pembelajaran siswa Sekolah Menengah Atas dengan menyesuaikan gaya belajar sehingga dapat meningkatkan prestasi belajar siswa.
PENGEMBANGAN MEDIA PEMBELAJARAN BERBASIS PERMAINAN KARTU DOMINO PADA POKOK BAHASAN FISIKA GERAK
Authors: Sumarni Ria Asep , Kumala Siti Ayu , Widiyatun Fita 
Published: April 2024

Telah banyak dikembangkan media pembelajaran berbasis permainan untuk membantu dalam proses belajar mengajar. Salah satunya adalah permainan kartu domino. Penelitian ini dilakukan dengan tujuan untuk mengembangkan media pembelajaran berbasis permainan yang berisi persamaan-persamaan di dalam mata kuliah Fisika Gerak. Fisika gerak merupakan mata kuliah di program studi Teknik Informatika, Universitas Indraprasta PGRI. Pengembangan media pembelajaran ini menggunakan model perancangan media pembelajaran model ADDIE. Model ADDIE dalam penelitian ini hanya sampai pada tahap Development (Pengembangan), untuk mengetahui kelayakan dari media pembelajaran. Hal ini diperoleh dari hasil penilaian validator, yaitu validator media dan validator materi. Dari penelitian ini diperoleh kesimpulan yaitu telah dibuat media pembelajaran dalam bentuk permainan kartu domino fisika gerak. Hasil validasi materi dan validasi media terhadap kartu permainan domino fisika gerak termasuk dalam kriteria yang layak, sehingga media berbasis permainan ini dapat digunakan sebagai media pembelajaran.
ANALISIS PERSEPSI MAHASISWA PENDIDIKAN FISIKA TERHADAP E-LEARNING MENGGUNAKAN TECHNOLOGY ACCEPTANCE MODEL (TAM)
Authors: Nasar Adrianus , Ika Yasinta Embu , Haji Daud Maimunah 
Published: April 2024

Penelitian ini bertujuan untuk mengetahui pengaruh persespsi mahasiswa program studi pendidikan fisika terhadap e-learning menggunakan Technology Acceptance Model (TAM). Data dikumpulkan melalui survey berbasis google form dengan menggunakan instrument sebanyak 15 butir. Sampel penelitian berjumlah 43 mahasiswa program studi Pendidikan Fisika yang diperoleh dengan random sampling. Data penelitian dianalisis menggunakan persamaan regresi linear dengan bantuan platform SPSS. Hasil penelitian menunjukkan bahwa: (1) ada pengaruh positif dan signifikan perceived ease of use e-learning terhadap perceived usefulness (Y = 0,858 + 0,754X; sig.= 0.000); (2) ada pengaruh positif dan signifikan perceived ease of use terhadap attitude toward to use e-learning (Y = 0,761 + 0,712X; sig.= 0.000) (3) ada pengaruh positif dan signifikan perceived usefulness terhadap attitude toward to use e-learning (Y = 0,658 + 0,730X; sig.= 0.000); (4) ada pengaruh positif dan signifikan perceived usefulness terhadap behavioural intention to use e-learning (Y = 0,0,040 + 0,950X; sig.= 0.000); dan (5) ada pengaruh positif dan signifikan attitude toward to use terhadap behavioural intention to use e-learning (Y = 0,668+ 0,817X; sig.= 0.000 pada mahasiswa program studi Pendidikan Fisika.
ANALISIS EFEKTIVITAS VIRTUAL LABORATORIUM AMRITA DALAM MENJALANKAN PRAKTIKUM PEGAS DAN HUBUNGAN VARIABEL DALAM KONTEKS HUKUM HOOKE
Authors: Kusuma Wardani Ayu , Malik Adam 
Published: April 2024

Tujuan penelitian ini adalah untuk mengetahui efektifitas virtual laboratorium Amrita dalam menjalankan praktikum pegas, hubungan antara variabel bebas dan variabel terikat pada materi pegas, dan kecocokan hasil praktikum dengan teori dasar pegas, yaitu Hukum Hooke. Metode penelitian yang digunakan adalah eksperimen dengan pendekatak kuantitatif. Hasil penelitian menunjukkan massa atau beban yang diberikan pada pegas berbanding lurus dengan perubahan atau peregangan pegas saat konstanta pegas dibuat konstan sebesar 30 N/m dan pengaruh konstanta juga berbanding terbalik dengan perubahan atau peregangan pegas saat massa atau beban pegas dibuat konstan sebesar 0,15 Kg. Kesimpulannya adalah Laboratorium virtual Amrita merupakan alternatif yang sesuai dan efisien bagi sekolah yang memiliki keterbatasan laboratorium konvensional dalam melakukan eksperimen pegas. Dalam konteks ini, laboratorium virtual Amrita telah berhasil menghasilkan data eksperimen pegas yang akurat dan sesuai dengan Hukum Hooke, yang merupakan dasar teori yang digunakan dalam praktikum pegas.
PERBANDINGAN MODEL FLIPPED CLASSROOM DENGAN MODEL DIRECT INSTRUCTION TERHADAP KEMAMPUAN PEMAHAMAN KONSEP FISIKA SMA
Authors: Putri Nurulita Purnama 
Published: April 2024

Penelitian ini bertujuan: 1) untuk: Untuk mengetahui kemampuan pemahaman konsep fisika yang diajarkan dengan menggunakan model Flipped Classroom pada peserta didik kelas X SMA Negeri 1 Cijeruk. 2) Untuk mengetahui kemampuan pemahaman konsep fisika yang diajarkan dengan menggunakan model Direct instruction pada peserta didik kelas X SMA Negeri 1 Cijeruk.3) Untuk mengetahui perbedaan kemampuan pemehaman konsep peserta didik yang diajarkan dengan menggunakan model Flipped Classroom dan model Direct Instruction pada peserta didik kelas X SMA Negeri 1 Cijeruk. Adapun desain dalam penelitian ini adalah True Experimantal Design dengan menggunakan pre-test-post-testt control group design. Dimana akan diambil dua kelas untuk diteliti, yaitu kelas eksperimen dan kelas kontrol yang keduanya dipilih secara acak (random). Populasi target dalam penelitian ini adalah SMA Negeri 1 Cijeruk. Populasi terjangkau pada penelitian ini adalah kelas X MIPA 1 dengan jumlah 35 siswa, X MIPA 2 berjumlah 36 siswa, dan kelas X MIPA 3 berjumlah 35 siswa dan total seluruhnya yaitu 106 siswa. Teknik sampling yang digunakan dalam penelitian ini adalah Purpossive Sampling. Pengumpulan data diambil dengan tes dalam bentuk essay. Teknik analisi data menggunakan Uji normalitas yang digunakan adalah uji Chi Square, Uji homogenitas yang digunakan adalah uji Fisher, dan uji hipotesis menggunakan uji-t. Hasil penelitian menunjukan bahwa: 1) Kemampuan pemahaman konsep fisika peserta didik kelas X MIPA 3 SMA Negeri 1 Cijeruk dengan menggunakan model Flipped Classroom nilai rata-rata pre-test (26.04) dan nilai rata-rata post-test (73.79) Kemampuan pemahaman konsep fisika peserta didik kelas X MIPA 1 SMA Negeri 1 Cijeruk dengan menggunakan model Direct instruction nilai rata-rata pre-test (25.64) dan nilai rata-rata post-test (65.90). 2) Terdapat perbedaan yang signifikan antara kemampuan pemahaman konsep fisika menggunakan model Flipped Classroom dan model Direct instruction, berdasarkan hasil uji hipotesis menggunakan uji t terhadap hasil Post-test, hasilnya t_hitung sebesar 2,48 dan nilai t tabel sebesar 2.00. 3) Berdasarkan hasil perhitungan t_hitung > t_tabel, maka Ha diterima dan Ho ditolak. Maka, kesimpulan yang didapatkan menunjukan bahwa penerapan model Flipped Classroom lebih efektif dibandingkan dengan model Direct instruction dilihat dari kemampuan pemahaman konsep setelah diberi perlakuan.
Susceptibility to poor arguments: The interplay of cognitive sophistication and attitudes
Authors: Marin Pinja M. , Lindeman Marjaana , Svedholm-Häkkinen Annika M. 
Published: April 2024

AbstractDespite everyday argumentation being crucial to human communication and decision-making, the cognitive determinants of argument evaluation are poorly known. This study examined how attitudes and aspects of cognitive sophistication, i.e., thinking styles and scientific literacy, relate to people’s acceptance of poorly justified arguments (e.g., unwarranted appeals to naturalness) on controversial topics (e.g., genetically modified organisms (GMOs)). The participants were more accepting of poorly justified arguments that aligned with their attitudes compared to those that opposed their attitudes, and this was true regardless of one’s thinking styles or level of scientific literacy. Still, most of the examined aspects of cognitive sophistication were also positively related to fallacy detection. The strongest cognitive predictors of correctly recognizing the fallacies were one’s scientific reasoning ability and active open-mindedness. The results thus imply that decreasing misleading attitude effects, and increasing certain aspects of analytic and scientific thinking, could improve argumentation.
Joyfull victim, Lensky, died: Tatiana's dream and the epigraph of the sixth chapter of Eugene Onegin as the keys to the novel’s knight-plan.
Authors: Кругликов С.Т. 
Published: April 2024

В статье рассматривается финальный эпизод сна Татьяны, который неточно предсказывает причину убийства Ленского. Эта неточность позволяет увидеть в Ленском не пассивную жертву, а активную фигуру защитника, что подтверждает контекст эпиграфа из Петрарки, отсылающий к Крестовому походу. Тема «рыцарского простодушия» и героизма пронизывает текст «Онегина» и создает внутренний сюжет «романа на старый лад», в котором жертва Ленского спасает и Татьяну, и Онегина от судьбы романтической героини и обывателя Зарецкого соответственно.
The article examines the final episode of Tatyana's dream, which inaccurately predicts the reason for Lensky's murder. This inaccuracy allows us to see in Lensky not a passive victim, but an active figure of a defender, which is confirmed by the context of the epigraph from Petrarch, which refers to the crusade. The theme of «knightly simplicity» and heroism permeates the text of Onegin and creates the internal plot of the «old-fashion novel», in which Lensky’s sacrifice saves Tatyana from the fate of the romantic heroine and Onegin – from the vulgar Zaretsky’s life.
PUSHKIN'S MOTIFS AND ALLUSIONS IN THE POETRY OF S.S. BEKHTEEV
Authors: Антипина Е.М. 
Published: April 2024

С. С. Бехтеев, поэт-эмигрант начала ХХ в., обращается к поэзии А. С. Пушкина на протяжении всего творчества. В статье исследуются литературные и биографические параллели поэта ХХ в. с судьбой Пушкина, пушкинские мотивы и аллюзии в лирике Бехтеева, отношение обоих писателей к поэтическому творчеству. Отдельно проводится анализ стихотворений «Поэт» 1902 г., «Лампада» 1898 г., «Лицей» 1941 г.
S. S. Bekhteev, an emigrant poet of the early twentieth century, refers to the poetry of A. S. Pushkin throughout his work. The article examines the literary and biographical parallels of the poet of the twentieth century with the fate of Pushkin, Pushkin's motives and allusions in the lyrics of Bekhteev, the attitude of both writers to poetic creativity. The analysis of the poems «Poet» in 1902 and «Lampada» in 1898, «Lyceum» in 1941 is carried out separately.
The ethnocultural component in the education of Chinese students in Russian universities
Authors: Черкашина Т.Т. , Левушкина А.М. , Новосад К.Ю. 
Published: April 2024

Лингводидактика на каждом этапе развития стремилась к поиску наиболее эффективных методик обучения и формирования коммуникативной компетентности иностранных учащихся. Китайские студенты, не испытывая затруднений в выполнении заданий репродуктивного характера, теряются при выполнении заданий творческих. В условиях активной мобильности современных учащихся, когда многоязычие становится культурной нормой, важное значение приобретает идея поликультурного образования с его опорой на национально-специфические основы моделей обучения и на прагматическую составляющую – овладение студентами знаниями и умениями в продуктивных видах речевой деятельности. В статье представлены результаты эмпирического исследования этнокультурного компонента и поиск эффективных приемов формирования текстуально-диалогической компетентности иностранных учащихся с учетом особенностей китайской модели обучения, опирающейся на конфуцианскую мораль.
At each stage of its development linguodidacticssought to find the most effective methods of teaching and forming the communicative competence of foreign students. Chinese students, having no difficulty in carrying out reproductive tasks, are lost in the performance of creative tasks. With the active mobility of today’s students, where multilingualism has become a cultural norm, the idea of multicultural education based on national-specific learning models and on a pragmatic component – mastering the knowledge and skills of students in creating their own author’s text on the basis of chria is becoming important. The article presents the results of empirical research of ethnocultural component and the search for effective methods of formation textual and dialogical competence of foreign students taking into account the features of the Chinese model of education based on Confucian morality.
Electron Densities of Transition Region Loops Derived from IRIS O iv Spectral Data
Authors: Liang Shiyu , Wang Ziyuan , Huang Zhenghua , Wei Hengyuan , Fu Hui , Xiong Ming , Xia Lidong 
Published: April 2024

Abstract
Loops are fundamental structures in the magnetized atmosphere of the Sun. Their physical properties are crucial for understanding the nature of the solar atmosphere. Transition region loops are relatively dynamic and their physical properties have not yet been fully understood. With spectral data of the line pair of O iv 1399.8 Å and 1401.2 Å (

T

max

=
1.4
×

10

5

K) of 23 transition region loops obtained by IRIS, we carry out the first systematic analyses to their loop lengths (L), electron densities (n

e
), and effective temperatures. We found electron densities, loop lengths, and effective temperatures of these loops are in the ranges of 8.9 × 109–3.5 × 1011 cm−3, 8–30 Mm, and 1.9 × 105–1.3 × 106 K, respectively. At a significant level of 90%, regression analyses show that the relationship between electron densities and loop lengths is n

e
[cm−3] ∝ (L[Mm])−0.78±0.42, while the dependences of electron densities on effective temperatures and that on the line intensities are not obvious. These observations demonstrate that transition region loops are significantly different than their coronal counterparts. Further studies on the theoretical aspect based on the physical parameters obtained here are of significance for understanding the nature of transition region loops.
L’Afrique dans les « Lettres à Pierre Schaeffer » (1957) et les romans de Victor Jean-Louis Baghio’o, ingénieur de la radio et écrivain d’origine antillaise
Authors: Bertrand Loïc 
Published: April 2024

Les lettres de Victor Jean-Louis à Pierre Schaeffer ont été écrites en 1957 durant une mission de l’ingénieur du son Jean-Louis dans plusieurs pays d’Afrique pour le compte de la SORAFOM (Société de radiodiffusion de la France d’outre-mer). Ce tapuscrit inédit constitue un document original qui peut être lu comme une archive de l’histoire de la SORAFOM, offrant une perspective singulière puisque Jean-Louis y critique la puissance coloniale en épousant le point de vue des Africains et des colonisés. Mais ces lettres peuvent aussi être lues comme une source des romans que cet ingénieur d’origine antillaise, fasciné par la représentation de l’Afrique, a publié sous le nom de plume Jean-Louis Baghio’o. Cet article propose une lecture croisée de ces deux aspects.
Des réseaux en temps de guerre
Authors: Dugas Guy 
Published: April 2024

Les guerres ont toujours été propices à la création de réseaux de toutes sortes. Cet article est consacré au mouvement “Jeune France” et aux liens qu’il entretint avec les artistes et écrivains d’Afrique du Nord coloniale, notamment Jean Amrouche, Edmond Brua, Armand Guibert, Max-Pol Fouchet, qui, comme M.-P. Fouchet ou A. Guibert, à la suite de la dissolution de ce mouvement, rallièrent des revues de résistance intellectuelle (Fontaine ou Poésie) ou qui, comme Brua, furent au contraire inquiétés à la Libération pour leurs activités dans le cadre de “Jeune France”.
Proteolytic system parameters in the brain of rats with hyperhomocysteinemia
Authors: Synelnyk Tatyana , Raksha Nataliia , Kostiuk Oleksandra , Kharchenko Olga , Rymsha Sofia , Korol Viktoria , Korol Anatoliy , Bernyk Oksana , Maievskyi Oleksandr 
Published: April 2024

Hyperhomocysteinemia (HHcy) is now being actively studied as a potential risk factor and/or biomarker for numerous pathological conditions, including brain diseases. This study aimed to analyze the proteolytic processes in the brains of rats with HHcy. Total proteolytic activity, metal-dependent, and serine proteases activities, the content of matrix metalloproteinases (MMPs), tissue inhibitor of metalloproteinases-1, cytokines, serine proteases, total protein and medium and low molecular-weight substances (MLMWS), were evaluated. HHcy was induced by DL-homocysteine thiolactone (HTL) daily intragastric administration (200 mg·kg–1 of body weight) to young and adult albino non-linear male rats for 8 weeks following rat sacrifice and brain harvesting. It was established that HHcy causes an increase in total proteolytic activity and a rise in MLMWS levels in rat brains. Serine protease activity increased to a greater extent compared to metal-dependent one, and bigger changes were observed in young rats. Rise in MMP-9 and -10 levels (in young animals), a decline in MMP-3 and -8 levels, and a decrease in the content of interleukin-1β, interferon-γ, interleukin-4 and tumor necrosis factor-α (the last two in young animals) was also detected. No significant changes were found in serine protease content. Therefore, proteolysis intensification in the brain of rats with HHcy is more likely caused by protease up-regulation through mechanisms stimulated by homocysteine, HTL, and oxidative stress, without involving pro-inflammatory signaling pathways.
Gossypol acetic acid regulates leukemia stem cells by degrading LRPPRC via inhibiting IL-6/JAK1/STAT3 signaling or resulting mitochondrial dysfunction
Authors: Ai Cheng-Jin , Chen Ling-Juan , Guo Li-Xuan , Wang Ya-Ping , Zhao Zi-Yi 
Published: April 2024

BACKGROUND
Leukemia stem cells (LSCs) are found to be one of the main factors contributing to poor therapeutic effects in acute myeloid leukemia (AML), as they are protected by the bone marrow microenvironment (BMM) against conventional therapies. Gossypol acetic acid (GAA), which is extracted from the seeds of cotton plants, exerts anti-tumor roles in several types of cancer and has been reported to induce apoptosis of LSCs by inhibiting Bcl2.
AIM
To investigate the exact roles of GAA in regulating LSCs under different microenvironments and the exact mechanism.
METHODS
In this study, LSCs were magnetically sorted from AML cell lines and the CD34+CD38- population was obtained. The expression of leucine-rich pentatricopeptide repeat-containing protein (LRPPRC) and forkhead box M1 (FOXM1) was evaluated in LSCs, and the effects of GAA on malignancies and mitochondrial function were measured.
RESULTS
LRPPRC was found to be upregulated, and GAA inhibited cell proliferation by degrading LRPPRC. GAA induced LRPPRC degradation and inhibited the activation of interleukin 6 (IL-6)/janus kinase (JAK) 1/signal transducer and activator of transcription (STAT) 3 signaling, enhancing chemosensitivity in LSCs against conventional chemotherapies, including L-Asparaginase, Dexamethasone, and cytarabine. GAA was also found to downregulate FOXM1 indirectly by regulating LRPPRC. Furthermore, GAA induced reactive oxygen species accumulation, disturbed mitochondrial homeostasis, and caused mitochondrial dysfunction. By inhibiting IL-6/JAK1/STAT3 signaling via degrading LRPPRC, GAA resulted in the elimination of LSCs. Meanwhile, GAA induced oxidative stress and subsequent cell damage by causing mitochondrial damage.
CONCLUSION
Taken together, the results indicate that GAA might overcome the BMM protective effect and be considered as a novel and effective combination therapy for AML.