bluuebunny/crossref_metadata_2025_split huggingface dataset:
Psychophatology Differences Between Pregnant Women who Conceived Naturally and Through Assisted Reproduction
Authors: Ramos-Fuentes M.I. , Cardoso-Moreno M.J. , Vaz-Leal F.J. , Fernandez-Sanchez N. , Rodriguez-Santos L. , Bejar A. , Berjano N. , Dominguez J.A. , González E. 
Published: March 2009

Objective:In the past few decades, new and more efficient techniques to help solve fertility problems have become widely available throughout the developed world. The aim of this study was to determine whether there were differences on psychopathology factors between women who had conceived after in vitro fertilization (IVF) and women who had conceived naturally.Methods:The sample was composed of 41 pregnant women of whom 28 women had conceived through assisted reproductive technology (IVF) and 13 had conceived naturally. Women were evaluated by week 20 of pregnancy at the Infanta Cristina University Hospital Obstetrics and Gynecology Service, in Badajoz. Women consented to complete the Symptom Checklist-90-Revised (SCL-90-R).Results:IVF women were characterized by higher scores on Anxiety Scale (t = 3.90; p = 0.045) and lower scores on Hostility Scale (t = 4.35; p = 0.041) than women who had conceived naturally. There were no differences in the others scales.Conclusions:IVF women appear to present a temperamental profile characterized by a tendency to anxiety. Further research is needed to firstly, confirm these preliminary findings, and secondly, to longitudinally explore its impact on pregnancy outcome and mother-infant attachment.
Treatment of Chronic Pain with Buprenorphine in a Veteran with Traumatic Brain Injury
Authors: Alao A. , Chung C. , Sachdeva S. 
Published: March 2009

Case presentation:We report a case of a 27-year-old Iraq War veteran with no previous psychiatric history who sustained severe traumatic brain injury (TBI) following a blast injury from an improvised explosive device. The patient subsequently suffered severe anxiety symptoms controlled only with combined therapy with benzodiazepines and venlafaxine. Even more disabling, the patient also experienced intractable headache and shoulder pain unresponsive to non-steroidal anti-inflammatory agents, tramadol, gabapentin, or NMDA-receptor antagonists. Given the risk of respiratory depression with his current medications, opioid analgesics were not favored for the management of his pain. The patient was started on sublingual buprenorphine at a dose of 8mg three times daily with significant improvement. This dose was maintained and the patient was able to function relatively pain-free.Conclusion:Chronic pain is a significant complication in patients with TBI and is reported by a majority of patients with TBI, regardless of the severity of the injury. The treatment of chronic pain among individuals can be challenging. Patients with TBI may be on other medications for impulse control, such as anticonvulsants and benzodiazepines. Further treatment with narcotic analgesics may therefore increase the risk of respiratory depression. Buprenorphine is a partial mu agonist whose effects plateau at higher doses, at which time it begins to act like an antagonist. It is this property at higher doses that limits its dose-dependent respiratory depression. Buprenorphine thus has the advantage of effective analgesia with minimal sedation and may be useful to treat chronic pain among TBI patients already taking benzodiazepines.
Clinical Implications of Anxiety in Diabetes: A Critical Review of the Evidence Base
Authors: Mitsonis C. , Dimopoulos N. , Psarra V. 
Published: March 2009

Introduction:Substantial literature supports clinically important associations between anxiety and chronic medical conditions. Diabetes is among the most psychologically and behaviorally demanding chronic medical illnesses. Anxiety has been associated with poor glycemic control, regimen adherence, and with accelerated rates of coronary heart disease in diabetic patients.Aim:The aim of this study is to provide an overview of the role of clinically significant anxiety in patients with diabetes mellitus.Methods:MEDLINE, EMBASE and PSYCINFO databases were searched using the combined search terms diabetes, diabetes mellitus, anxiety symptoms and anxiety disorders. Published reference lists were also examined. In total 25 studies were identified that fulfilled the inclusion criteria.Results:Anxiety was present in 41.7% of diabetic patients. There was no significant difference between those with Types 1 and types 2 diabetes. The rate of elevated symptoms was significantly higher in diabetic women than in diabetic men. General anxiety disorder was the most prevalent of the clinical disorders and was found in 13.2% of the diabetic patients. The rates of the other anxiety disorders were within the range of those reported in community studies. Treatment of anxiety was associated with improved glycemic control, particularly in the subgroup of patients with severe anxiety.Conclusions:Emerging data offer a strong argument for the role of anxiety in diabetes. Psychological interventions and/ or pharmacological treatments in patients with diabetes are needed, in order to increase treatment adherence and control of the disease and improve patients’ functioning and quality of life.
Functional and Quality of Life Impairment in Generalized Anxiety Disorder: Effect of Short-term Treatment with Pregabalin and Venlafaxine-XR
Authors: Mychaskiw M.A. , Alvir J.M. , Hoffman D.L. , Herman B.K. , Joshi A. 
Published: March 2009

Aims:To determine the incidence and clinical correlates of functional and quality of life (QoL) impairment in patients with generalized anxiety disorder (GAD), and to evaluate the efficacy of pregabalin and venlafaxine-XR in improving functional outcomes.Methods:A double-blind trial in adults who met DSM-IV criteria for GAD, with a HAM-A total score ≥20, randomized to 8-weeks of flexible-dose treatment with pregabalin (300-600 mg/d, N=121), venlafaxine-XR(75-225 mg/d, N=125), or placebo (N=128). Anxiety-related impairment in QoL was evaluated using the Quality of Life, Enjoyment, and Satisfaction Questionnaire (Q-LES-Q) and impairment in functioning using the Sheehan Disability Scale (SDS).Results:At baseline, a similar proportion of patients in the 3 treatment groups met criteria for impairment on the Q-LES-Q (70.1%-77.6%) and SDS (74.1%-82.7%). For all groups combined, baseline impairment was more highly correlated with psychic than somatic anxiety on both the Q-LES-Q and SDS (Spearman r-values, -0.32 vs. -0.28 and 0.27 vs. 0.14,respectively). On the SDS but not on the Q-LES-Q, significantly more subjects in the pregabalin (67.2%) and venlafaxine-XR (59.5%) groups had improvement into the normative range compared with placebo (42.9%; p< 0.05) at endpoint. The mean HAM-A change score (all subjects) was significantly greater among patients whose Q-LES-Q returned to normal (“remitters” vs. non-remitters: -19.3 vs. -11.9; p< 0.05).Conclusion:At baseline, approximately 75% of GAD patients reported moderate-to-severe impairment in QoL and functioning which was modestly correlated with severity of GAD symptomatology. Pregabalin produced improvement in QoL and functioning that was correlated with reduction in anxiety symptom severity.
Sexual Dysfunctions in Anxious Depressive Disorders
Authors: Tiugan A. 
Published: March 2009

Background:The ethiopathogenic mechanisms of depression and anxiety overlap at a certain moment on most part of those of the sexual dysfunction. Hypercorticolezemia from the anxious depressive disorders, with direct impact on the hypocampus (reducing the volume), through the two mechanisms (biological and organic) may generate and especially accentuate the dysfunctions in the sexual activity.Objectives:In more than few cases, the anxious depressive disorders are accompanied by sexual dysfunctions, whDuring antidepressant therapy, especially with inhibitors specific for recapturing serotonine, different types of sexual dysfunctions may appear.Methods:In a retrospective examination, out of 420 patients fulfilling the DSM IV R criteria for the anxious and depressive with anxious and depressive disorder, the presence of sexual dysfunction was highlighted in 340 patients (80,9%). In 260 patients (76,47%) the sexual dysfunction was present in the clinical board of anxiety and depression; in 78 patients (30%) the sexual dysfunction accentuated during antidepressant therapy (predominantly with specific inhibitors for recapturing serotonin). In 80 patients (23,53%), the anxious depressive symptomatology was preceded by sexual dysfunctions in various clinical forms. ich accentuate the anxiety and the depression.Conclusions:The presence of sexual dysfunction in an anxious depressive board represents a negative predictive factor in the evolution of the affective disorder, delaying remission. The use of the mood stabilizer, by increasing GABA in the mezocortical circuit and equilibrating the GABA/DOPAMINE, can be beneficial for the improvement of the sexual dysfunction in the anxious depressive disorders.
Estimation of placebo Effect in Therapy of Generalized Anxiety Disorder
Authors: Grigorova O. 
Published: March 2009

Studying of placebo response in patients with Generalized Anxiety Disorder (GAD) was the aim of research. 90 patients (68 female, 22 male, mean age of 33 years) were studied. All patients accepted inactive placebo (P) within 7 days and then - Alprazolam (A) in a dose of 1-3 mg per day within 4 weeks. Efficacy of treatment was estimated weekly by the HAM-A scale. After week of placebo reception, patients with HAM-A score < 9 made group of remission (R), with ≥50% HAM-A reduction - placebo responders group (PR), with HAM-A reduction 25-49% - partial placebo responders group (PPR), ≤ 25% HAM-A reduction - placebo nonresponders group (PNR).After week of reception placebo 16.6% of patients HAM-A made group R, 26.7% - PR; 30% - PPR, 26.7% - PNR. After active therapy (A) Therapeutic Remission group (RT - HAM-A score < 9) consisted of 100% of group R, 75% of PR, 81.5% of PPR and 8,33% of PNR. 25% of PR, 18% of PPR and 8.33% of PNR became Therapeutic Responders (TR - HAM-A reduction >50%). Partial Therapeutic Responders (PTR - HAM-A reduction 25-49%) and Therapeutic Nonresponders (TNR ≤ 25% HAM-A reduction) consisted only of PNR (62.5% and 20.83%).Absent response on (P) frequently correlated with low efficacy of therapy of (A). High positive placebo effect (PE) was defined in patients in whom improvement after transferring on active therapy became even more expressed. The received data allow to consider presumably PE like predictor of efficacy of benzodiazepines therapy for GAD.
Autoantibodies in Bipolar and Cluster B Personality Disorders
Authors: Almeida J. Traça , Barahona-Correa B. , Santos A. , da Silva J. Alves , Filipe P. , Talina M. , Xavier M. 
Published: March 2009

Prevalence of depression and other common psychiatric disorders in autoimmune diseases has been extensively documented. The association between subclinical autoimmunity and behavioural or psychiatric syndromes remains less studied. The best known example is raised titres of autoantibodies with high affinity for the basal ganglia in some obsessive compulsive spectrum syndromes (e.g. Paediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcal infections). The possible role of autoimmunity in impulse control disorders remains understudied.We proposed to study the relation between autoimmunity, affective bipolarity and impulsive psicopathology.Methods:14 bipolar, 10 cluster B personality disorder inpatients. Titres for rheumatoid factor (RA), antithyroglobulin (ATG), antiperoxidase (APO) antinuclear (ANA), anti-neutrophil cytoplasmic (ANCA) and antistreptolysin (ASO) antibodies were measured in all subjects. Psychiatric assessment: non-structured psychiatric interview, MINI International Neuropsychiatric Interview and Millon Clinical Multiaxial Inventory-II.Results:21,4% of bipolar patients had positive ATG titre vs 11,1% in the cluster B personality group. 28,6% of bipolar patients had positive APO titre vs 22,2% in the cluster B personality group. 16,7% of bipolar patients had positive ASO titre vs 30,0% in the cluster B personality group. None of this differences reached significance.ASO titre correlated significantly with antisocial (rho=0,435, p=0,043) and autodestructive (rho=0,461, p=0,031) ratings and almost significantly with borderline (rho=0,420, p=0,052) ratings.Conclusions:The results obtained partly agree with the existing studies. As far as we know a possible correlation between ASOs and impulsive behaviour has not been previously described. The results obtained call for further investigation in the subject.
Effects of Parent Training on Salivery Cortisol in Children and Adolescents with Disruptive Behavior Disorder
Authors: Attari A. , Motamedi M. , Siavash M. , Hassanzadeh A. , Soltani M. 
Published: March 2009

Aims:Since adulthood antisocial, aggressive and delinquent behaviors often have their onset early in life, investigating the association between biological factors and disruptive behaviors in children and adolescents are important and are emphasized on in the recent years. Baseline cortisol level seems to be a valuable biological marker of individuals with Disruptive Behavior Disorder (DBD). This study examined the effect of parent training on salivary cortisol levels of children with DBD.Methods:Saliva samples were assayed to determine cortisol levels in nineteen clinic-referred children with DBD (aged 8 through 13 years) before and after an eight-session parent training program. Children's disruptive behaviors were assessed by Child Behavior Check List before and after the intervention.Results:Children's salivary cortisol increased significantly after parent training sessions. Children with DBD who had lower basal cortisol levels had more severe disruptive behaviors and a better response to intervention by parent training as assessed by changes in cortisol levels and disruptive behaviour scores. However, post-interventional reduction of disruptive behaviors and increase in cortisol level was significant for all levels of baseline cortisol.Conclusions:Parent training is an effective method for behavioral modification in DBD. Salivary cortisol may be considered a predictive factor for severity of the child or adolescent's disruptive behaviors and also for response of those behaviors to parent training.
Influence of Subanesthetic Dose of Ketamine on Theta Cordance in Healthy Volunteers: Implications for Antidepressant Effect
Authors: Brunovsky M. , Horacek J. , Bares M. , Novak T. , Tislerova B. , Sos P. , Krajca V. , Höschl C. 
Published: March 2009

Aims:A series of clinical studies demonstrated that QEEG prefrontal theta cordance value decreases after one week of treatment in responders to antidepressants and precedes clinical improvement. Ketamine, a non-competitive antagonist of NMDA receptors, has a unique rapid antidepressant effect but its influence on theta cordance is still unknown.Methods:In a double-blind, cross-over, placebo-controlled experiment we studied the influence of ketamine (0.54 mg/kg) on theta cordance in a group of 20 right-handed healthy volunteers. Participants were evaluated with the Brief Psychiatric Rating Scale before infusion and after 10 and 30 min. Three EEG segments obtained at baseline and prior to BPRS examinations at 10 and 30 min after dosing were entered into spectral analyses and QEEG cordance values in theta frequency band were calculated for four regions (prefrontal, central, left and right temporal).Results:Ketamine infusion induced a decrease in prefrontal theta cordance at 10 (p=0.04) and 30 min (p=0.02) and a significant increase of theta cordance in central region at both time points (p=0.01). We observed no significant effect on cordance values in the left and right temporal regions.Conclusions:Our data indicate that ketamine infusion immediately induces similar changes as monoaminergic-based antidepressants do gradually after a series of downstream signaling steps. The reduction in theta prefrontal cordance could serve as a marker of fast antidepressant effect of ketamine, a hypothesis that should be tested in antidepressants-refractory patients.This study was supported by a grant of IGA MHCR NR/9330-3 and by a project of MEYS CR VZ0021620816.
ERKs - a New Marker in Psychiatry?
Authors: Mateus M. , da Silva Borges G.P. , Silva C. , Lourenço F. 
Published: March 2009

Recent studies involved the pathways of kinases regulated by extracellular signal (ERK - extracellular signal regulated kinases), a broad range of key cellular processes, in the mechanisms of depression and consequently in the action of antidepressants. It is also known that the use of specific inhibitors of phosphorylation of ERKs1 / 2 showed to have antidepressant effect in animal models. Fluoxetina (SSRI) was recently discovered to be a potente inhibitor of phosphorylation of ERKs. The ERKs1 / 2 and recently the 3, are present in neurons and glia, these also engaged in biological mechanisms of depression.The authors propose to do, based on the current literature, the characterization of the type (s) of cell (s) where changes in activation of ERKs1 / 2, occur during depression, and during the administration of antidepressants, in order to understand, to what extent these kinases may be considered as biological markers of depression. Possibly also to examine the feasibility of using these markers in clinical use.
Anxiety, Depression, Quality of Life Related to Induction of Heat Shock Protein 70 (HSP70i) in Biopsies of Inflammatory Bowel Disease Patients
Authors: Vlachos I. , Coccossis M. , Barbati C. , Goumas C. , Nomikou L. , Triantaphyllidis J.K. , Malgarinos G. , Papadimitriou G.N. , Patsouris E. , Nicolopoulou P. 
Published: March 2009

Anxiety and Depression have often been associated in literaure, with the course of the Inflammatory Bowel Diseases(IBD):Crohn's Disease (CD) and Ulcerative Colitis (UC). The chronic character of the disease influences Quality of Life (QoL) of affected patients.Aim:To measure Anxiety, Depression and Qol in IBD patients through psychometric tools and correlate these results with the presence or absence of the inducible form of Heat Shock Protein 70 (HSP70i) in the histologic examination of the same patients. The HSPs are cellular proteins with ubiquitus presence in humans, known to exert cytoprotecive functions when induced under conditions of cellular stress ( heat, hypoxia, etc as well as psychophysiological stress).Мethod:The study was conducted between 2005 and 2008 in two general state hospitals in the broader area of Athens, Greece.Sample:59 IBD patients hospitalized for the endoscopic investigation of a possible relapse of their disease participated in the study(37 UC, 21 CD, 1 Intermediate Colitis).Procedure:A cross-sectional study was conducted through administration of the inventories and the comparison of their values with the presence of HSP70i in the histologic examination of each patient.Instruments used:a.WHOQOL-BREF;b.Zung Depression Scale;c.STAI (State Trait Anxiety Inventory);d.Нospital Anxiety Depression Scale;e.SPA-810 Antigen for HSP70i (Stressgen, Canada).Results:The X2 distribution for nominal data showed that the presence of the inducible form of HSP70 in the lymphoid tissue, the neutrophiles and the monocytes of IBD patients’ histologic examination is not the same (not homogeneous) regarding depression, anxiety and quality of life, suggesting its possible psychosomatic character (X2>6.635,d.f.=1,p< 0.01).
Development and use of a Biological Rhythm Interview
Authors: Giglio L.M. , Magalhães P.V.d.S. , Andreazza A. , Walz J. , Jakobsen L. , Rucci P. , Rosa A.R. , Vieta E. , Kapczinski F. 
Published: March 2009

Introduction:As several lines of evidence point to irregular biological rhythms in bipolar disorder, and its disruption may lead to new illness episodes, having an instrument that measures biological rhythms is critical. This report describes the validation of a new instrument, the Biological Rhythms Interview of Assessment in Neuropsychiatry (BRIAN), designed to assess biological rhythms in the clinical setting.Methods:Eighty-one outpatients with a diagnosis of bipolar disorder and 79 control subjects matched for type of health service used, sex, age and educational level were consecutively recruited. After a pilot study, 18 items evaluating sleep, activities, social rhythm and eating pattern were probed for discriminant, content and construct validity, concurrent validity with the Pittsburgh Sleep Quality Index (PSQI), internal consistency and test-retest reliability.Results:A three-factor solution, termed sleep/ social rhythm factor, activity factor and feeding factor, provided the best theoretical and most parsimonious account of the data; items essentially loaded in factors as theoretically intended, with the exception of the sleep and social scales, which formed a single factor. Test-retest reliability and internal consistency were excellent. Highly significant differences between the two groups were found for the whole scale and for each BRIAN factor. Total BRIAN scores were highly correlated with the global PSQI score.Discussion:The BRIAN scale presents a consistent profile of validity and reliability. Its use may help clinicians to better assess their patients and researchers to improve the evaluation of the impact of novel therapies targeting biological rhythm pathways.
Waist Circumference as a Simple and Meaningful Means to Assess Insulin Resistance Among Outpatients with Bipolar Disorder
Authors: Gomes F.A. , Magalhães P.V.d.S. , Kunz M. , Andreazza A. , Silveira L. , Weyne F. , Ceresér K. , Furlanetto T. , Kapczinski F. 
Published: March 2009

Aims:To evaluate insulin resistance (IR) among outpatients with bipolar disorder (BD) in order to determine clinical correlates of IR in this patient population.Method:We performed a cross-sectional study in sixty-five DSM-IV-TR BD patients consecutively assessed from January to August 2007 at the Bipolar Disorder Program, Hospital de Clínicas de Porto Alegre, Brazil. IR was diagnosed using the homeostatic model assessment - insulin resistance (HOMA-IR). Metabolic syndrome (MS) diagnosis and metabolic variables were assessed using three definitions: National Cholesterol Educational Program - Adult Treatment Panel III (NCEP-ATP III); NCEP-ATP III modified criteria and International Diabetes Federation (IDF).Results:IR was present in 43.1% of the sample (women 40%, men 44.4%). The prevalence of MS defined by the NCEP-ATP III criteria was 32.3%, NCEP-ATP III modified was 40% and IDF was 41.5%. NCEP-ATP III modified criteria showed the best trade-off between sensitivity (78.6%) and specificity (89.2%) to detect insulin resistance. Waist circumference was the best clinical parameter associated with IR in the linear regression model (B=0.014, SE 0.002, t=6.18, p< 0.001). Areas under ROC curves were similar for waist circumference and different MS definitions (chi2=2.98, df=3, p=0.39).Conclusion:Currently MS criteria may provide reasonable sensitivity and specificity for the detection of insulin resistance in patients with bipolar disorder. Waist circumference may be a simple and inexpensive means to predict insulin resistance in this population.