bluuebunny/crossref_metadata_2025_split huggingface dataset:
Biodiversity value of agricultural drainage ditches: a comparative analysis of the aquatic invertebrate fauna of ditches and small lakes
Authors: Verdonschot Ralf C. M. , Keizer‐vlek Hanneke E. , Verdonschot Piet F. M. 
Published: September 2011

ABSTRACT

Drainage ditches are a common aquatic habitat in the lowland agricultural landscape of north‐western Europe. The invertebrate fauna of these waters is poorly known compared with that of the semi‐natural wetland fragments found in this region. While most wetlands are designated as nature reserves, drainage ditches are generally viewed purely as hydrological infrastructure in support of agriculture.
To assess the conservation value for aquatic invertebrates of these man‐made habitats compared with that of wetland fragments, the taxonomic composition and life‐history characteristics of invertebrate assemblages inhabiting nine small lakes and nine ditches in peatlands in the Netherlands were compared, as well as the environmental characteristics potentially influencing assemblage structure.
Although ditches comprised a smaller water volume, contained less diverse vegetation, displayed larger fluctuations in nutrient concentrations and were regularly managed, the total number of invertebrate taxa recorded per taxonomic group was comparable with that in small lakes, as was the number of nationally uncommon to very rare taxa.
Similarity in life‐history characteristics between the two water‐body types was high, except that a higher proportion of atmospheric air breathers was found in ditches, and more plant miners and collector–filterers in small lakes.
On a regional scale, a relatively high inter‐ditch taxon dissimilarity was observed, resulting in total diversity estimates for ditches exceeding those of small lakes.

This study showed that drainage ditches can be a significant habitat type for aquatic invertebrates. In the Netherlands, water bodies in peatland agricultural areas can contain a diverse invertebrate fauna, similar to that of water bodies in nearby nature reserves.
Copyright © 2011 John Wiley & Sons, Ltd.
The developing zebrafish (Danio rerio): A vertebrate model for high‐throughput screening of chemical libraries
Authors: Lessman Charles A. 
Published: September 2011

AbstractThe zebrafish, Danio rerio, a small, tropical freshwater species native to Pakistan and India, has become a National Institutes of Health‐sanctioned model organism and, due to its many advantages as an experimental vertebrate, it has garnered intense interest from the world's scientific community. Some have labeled the zebrafish, the “vertebrate Drosophila,” due to its genetic tractability, small size, low cost, and rapid development. The transparency of the embryo, external development, and the many hundreds of mutant and transgenic lines available add to the allure. Now it appears, the zebrafish can be used for high‐throughput screening (HTS) of drug libraries in the discovery process of promising new therapeutics. In this review, various types of screening methods are briefly outlined, as are a variety of screens for different disease models, to highlight the range of zebrafish HTS possibilities. High‐content screening (HCS) has been available for cell‐based screens for some time and, very recently, HCS is being adapted for the zebrafish. This will allow analysis, at high resolution, of drug effects on whole vertebrates; thus, whole body effects as well as those on specific organs and tissues may be determined. Birth Defects Research (Part C) 93:268–280, 2011. © 2011 Wiley‐Liss, Inc.
A high‐content screening assay in transgenic zebrafish identifies two novel activators of fgf signaling
Authors: Saydmohammed Manush , Vollmer Laura L. , Onuoha Ezenwa Obi , Vogt Andreas , Tsang Michael 
Published: September 2011

AbstractZebrafish have become an invaluable vertebrate animal model to interrogate small molecule libraries for modulators of complex biological pathways and phenotypes. We have recently described the implementation of a quantitative, high‐content imaging assay in multi‐well plates to analyze the effects of small molecules on Fibroblast Growth Factor (FGF) signaling in vivo. Here we have evaluated the capability of the assay to identify compounds that hyperactivate FGF signaling from a test cassette of agents with known biological activities. Using a transgenic zebrafish reporter line for FGF activity, we screened 1040 compounds from an annotated library of known bioactive agents, including FDA‐approved drugs. The assay identified two molecules, 8‐hydroxyquinoline sulfate and pyrithione zinc, that enhanced FGF signaling in specific areas of the brain. Subsequent studies revealed that both compounds specifically expanded FGF target gene expression. Furthermore, treatment of early stage embryos with either compound resulted in dorsalized phenotypes characteristic of hyperactivation of FGF signaling in early development. Documented activities for both agents included activation of extracellular signal‐related kinase (ERK), consistent with FGF hyperactivation. To conclude, we demonstrate the power of automated quantitative high‐content imaging to identify small molecule modulators of FGF. Birth Defects Research (Part C) 93:281–287, 2011. © 2011 Wiley‐Liss, Inc.
No effects of short‐term GSM mobile phone radiation on cerebral blood flow measured using positron emission tomography
Authors: Kwon Myoung Soo , Vorobyev Victor , Kännälä Sami , Laine Matti , Rinne Juha O. , Toivonen Tommi , Johansson Jarkko , Teräs Mika , Joutsa Juho , Tuominen Lauri , Lindholm Harri , Alanko Tommi , Hämäläinen Heikki 
Published: September 2011

AbstractThe present study investigated the effects of 902.4 MHz Global System for Mobile Communications (GSM) mobile phone radiation on cerebral blood flow using positron emission tomography (PET) with the 15O‐water tracer. Fifteen young, healthy, right‐handed male subjects were exposed to phone radiation from three different locations (left ear, right ear, forehead) and to sham exposure to test for possible exposure effects on brain regions close to the exposure source. Whole‐brain [15O]H2O–PET images were acquired 12 times, 3 for each condition, in a counterbalanced order. Subjects were exposed for 5 min in each scan while performing a simple visual vigilance task. Temperature was also measured in the head region (forehead, eyes, cheeks, ear canals) during exposure. The exposure induced a slight temperature rise in the ear canals but did not affect brain hemodynamics and task performance. The results provided no evidence for acute effects of short‐term mobile phone radiation on cerebral blood flow. Bioelectromagnetics 33:247–256, 2012. © 2011 Wiley Periodicals, Inc.
Determination of curdione in rabbit plasma by liquid chromatography mass spectrometry
Authors: Ma Jianshe , Dong Jianyong , Lin Guanyang , Yue Lei , Xiang Zheng , Xu Renai , Hu Lufeng , Wang Xianqin 
Published: September 2011

ABSTRACTA sensitive and selective liquid chromatography mass spectrometry method for determination of curdione in rabbit plasma was developed. After addition of tramadol as internal standard (IS), protein precipitation by acetonitrile was used for sample preparation. Chromatographic separation was achieved on a Zorbax SB‐C18 (2.1 × 50 mm, 3.5 µm) column with acetonitrile–0.1% formic acid as mobile phase with gradient elution. An electrospray ionization source was applied and operated in positive‐ion mode; selective ion monitoring was used for quantification using target fragment ions m/z 237 for curdione and m/z 264 for the IS. Calibration plots were linear over the range of 20–4000 ng/mL for curdione in plasma. The lower limit of quantification for curdione was 20 ng/mL. Mean recovery of curdione from plasma was in the range 94.3–98.4%. The RSD of intra‐day and inter‐day precision were both less than 9%. This method is simple and sensitive enough to be used in pharmacokinetic research for the determination of curdione in rabbit plasma. Copyright © 2011 John Wiley & Sons, Ltd.
Active learning in robotics based on simulation tools
Authors: López‐Nicolás G. , Romeo A. , Guerrero J. J. 
Published: September 2011

AbstractSimulation is a powerful tool that has a very important role in the different areas of research, development, and education. In particular, simulation tools are widely used in robotics. In this article, we present an active learning experience based on simulation tools in the framework of robotics courses taught at engineering degrees. It is well known that the field of robotics involves many disciplines taught in higher education, such as mechanics, electronics, or computer science. In the context of a robotics course for an Industrial Engineering Masters degree, the different topics addressed can benefit from the use of simulation tools. Additionally, the benefits of active learning activities have been widely acknowledged and discussed. The main contribution of this work is the simulation tools fully integrated in the project‐based activity designed. Thus, one of the contributions is the software provided, developed with a clear teaching focus, and the successful teaching experience with a high academic level thanks in part to the simulation tools. Here, we describe the methodology and the new simulation tools, RobotScene and SGRobot, developed for this project‐based learning activity. This activity has been carried out successfully for several years; and our experience is that it motivates the students and improves their understanding of the theoretical concepts involved. We also present the academic results that support the benefits of the activity presented. © 2011 Wiley Periodicals, Inc. Comput Appl Eng Educ 22:509–515, 2014; View this article online at wileyonlinelibrary.com/journal/cae; DOI 10.1002/cae.10.1002/cae.20576
ChemInform Abstract: Palladium‐Catalyzed Ring‐Contraction and Ring‐Expansion Reactions of Cyclic Allyl Amines.
Authors: Dubovyk Igor , Pichugin Dmitry , Yudin Andrei K. 
Published: September 2011

AbstractThe ring‐contraction of seven‐ and eight‐membered allylic amines provides pyrrolidine and piperidine derivatives.
ChemInform Abstract: RhIII‐Catalyzed Oxidative Olefination of Vinylic C—H Bonds: Efficient and Selective Access to Di‐Unsaturated α‐Amino Acid Derivatives and Other Linear 1,3‐Butadienes.
Authors: Besset Tatiana , Kuhl Nadine , Patureau Frederic W. , Glorius Frank 
Published: September 2011

AbstractThe Rh‐catalyzed oxidative C—H olefination of functionalized alkenes such as unsaturated amino acids is developed.
ChemInform Abstract: InCl3‐Catalyzed Carbene Insertion into O—H Bonds: Efficient Synthesis of Ethers.
Authors: Krishna Palakodety Radha , Prapurna Y. Lakshmi , Alivelu Munagala 
Published: September 2011

AbstractReaction of the carbene derived from ester (II) with alcohols results in formation of different types of ethers.
ChemInform Abstract: Catalyst‐Free Regio‐ and Stereospecific Synthesis of β‐Sulfonamido Dithiocarbamates: Efficient Ring‐Opening Reactions of N‐Tosyl Aziridines by Dialkyldithiocarbamates.
Authors: Alagiri Kaliyamoorthy , Prabhu Kandikere Ramaiah 
Published: September 2011

AbstractRing‐opening of aziridines with thiocarbamate (II) results in regioselective formation of β‐sulfonamido dithiocarbamates.
ChemInform Abstract: N‐Heterocyclic Carbene (NHC)‐Catalyzed Intermolecular Hydroacylation of Cyclopropenes.
Authors: Bugaut Xavier , Liu Fan , Glorius Frank 
Published: September 2011

AbstractThe organocatalyzed reaction of aromatic aldehydes with cyclopropenes under mild conditions affords valuable acylcyclopropanes in moderate to high yields with high diastereoselectivity.
ChemInform Abstract: Synthesis of Enaminones in Aqueous Media Using Catalytic Dilute HCl.
Authors: Cui Bin , Wang Rui‐Hua , Chen Li‐Zhuang , Jin Yan , Ha Guang‐Fan 
Published: September 2011

AbstractA highly efficient, environmentally friendly and Convenient method for the synthesis of enaminones (III) is developed.
ChemInform Abstract: Recyclable Merrifield Resin‐Supported Thiourea Organocatalysts Derived from L‐Proline for Direct Asymmetric Aldol Reaction.
Authors: Li Jia , Yang Gengxu , Qin Yanyan , Yang Xinran , Cui Yuanchen 
Published: September 2011

AbstractAll resin‐supported thioureas (I) are efficient catalysts for the aldol reaction of cyclohexanone with aromatic aldehydes.
ChemInform Abstract: Bidentate Lewis Acids for the Activation of 1,2‐Diazines — A New Mode of Catalysis.
Authors: Kessler Simon N. , Neuburger Markus , Wegner Hermann A. 
Published: September 2011

AbstractBidentate Lewis acid (BLA) is applied to catalyze the inverse electron demand Diels—Alder reaction of phthalazines with various enamines, most of which can be prepared in situ from pyrrolidine and ketones.
ChemInform Abstract: Three‐Component Synthesis of New Unsymmetrical Oxindoles via Friedel—Crafts Type Reaction.
Authors: Ahadi Somayeh , Moafi Leila , Feiz Afsaneh , Bazgir Ayoob 
Published: September 2011

AbstractThree‐component reaction of indandione (II) with isatins (I) and dimethylaniline (III) is efficiently catalyzed by LiClO4 to give title oxindoles (IV) in high yields.
ChemInform Abstract: Exercising Regiocontrol in Palladium‐Catalyzed Asymmetric Prenylations and Geranylation: Unifying Strategy Toward Flustramines A and B.
Authors: Trost Barry M. , Malhotra Sushant , Chan Walter H. 
Published: September 2011

AbstractThe regio‐ and stereoselective outcome of the reactions can be determined by an appropriate choice of ligand, solvent, and additive.
ChemInform Abstract: Asymmetric Synthesis of (S,S,S)‐2‐Aza‐bicyclo[3.3.0]‐octane‐3‐carboxylic Acid Benzyl Ester: Formal Synthesis of Ramipril.
Authors: Kondaiah G. C. M. , Vivekanandareddy M. , Reddy L. Amarnath , Anurkar Smita V. , Gurav V. M. , Ravikumar M. , Bhattacharya Apurba , Bandichhor Rakeshwar 
Published: September 2011

AbstractUsing (S)‐1‐amino‐2‐(methoxymethyl)pyrrolidine (SAMP) (II) as chiral auxiliary, a new and innovative route to title compound (VIII), a key intermediate in the synthesis of the ACE inhibitor ramipril, is described.
ChemInform Abstract: A Novel and Unusually Long‐Lived Chemiluminophore Based on the 7‐Hydroxycoumarin Scaffold.
Authors: Koci Jan , Grandclaude Virgile , Massonneau Marc , Richard Jean‐Alexandre , Romieu Anthony , Renard Pierre‐Yves 
Published: September 2011

Abstractsynthesis and chemiluminescent properties of new dioxetane (I)
ChemInform Abstract: Novel Imidazo[4,5‐b]pyridine and Triaza‐benzo[c]fluorene Derivatives: Synthesis, Antiproliferative Activity and DNA Binding Studies.
Authors: Hranjec Marijana , Lucic Borka , Ratkaj Ivana , Kraljevic Pavelic Sandra , Piantanida Ivo , Pavelic Kresimir , Karminski‐Zamola Grace 
Published: September 2011

AbstractImidazopyridines (I), (IV), and (VII) are obtained via cyclocondensation between the corresponding diaminopyridines and acrylic acids and by condensation between methylimidazopyridines and cyanobenzaldehyde, resp.
ChemInform Abstract: The Synthesized Novel Fluorinated Compound (LJJ‐10) Induces Death Receptor‐ and Mitochondria‐Dependent Apoptotic Cell Death in the Human Osteogenic Sarcoma U‐2 OS Cells.
Authors: Hour Mann‐Jen , Yang Jai‐Sing , Chen Tai‐Lin , Chen Kuan‐Tin , Kuo Sheng‐Chu , Chung Jing‐Gung , Lu Chi‐Cheng , Chen Chia‐Yi , Chuang Yi‐Hsuan 
Published: September 2011

AbstractBenzamides (I), prepared by a standard methodology, provide access to quinazolinones (III) by thermal cyclodehydration/dehydrogenation.
ChemInform Abstract: New Condensed Pyrroles of Potential Biological Interest Syntheses and Structure—Activity Relationship Studies.
Authors: Mohamed Mosaad S. , Kamel Rehab , Fatahala Samar S. 
Published: September 2011

AbstractPyrrole derivatives such as (IV) and (V) are employed for the straightforward derivatization providing pyrrolo‐, pyrrolotriazolo‐, and pyrrolotetrazolopyrimidines as novel anti‐inflammatory and antimicrobial agents.
ChemInform Abstract: Synthesis, Antitumor and Antimicrobial Activities of 4‐(4‐Chlorophenyl)‐3‐cyano‐2‐(β‐O‐glycosyloxy)‐6‐ (thien‐2‐yl)‐nicotinonitrile.
Authors: El‐Sayed Hassan , Moustafa Ahmed H. , Haikal Abd El‐Fattah Z. , Abu‐El‐Halawa Rajab , El Ashry El Sayed H. 
Published: September 2011

AbstractGlycosylation of pyridinone (IV) under conventional or microwave‐assisted conditions affords the corresponding O‐glycosides instead of the N‐glycosides.
ChemInform Abstract: Synthesis, Biological Evaluation, and Docking Studies of Gigantol Analogues as Calmodulin Inhibitors.
Authors: Reyes‐Ramirez Adelfo , Leyte‐Lugo Martha , Figueroa Mario , Serrano‐Alba Trinidad , Gonzalez‐Andrade Martin , Mata Rachel 
Published: September 2011

AbstractDiphenylmethanes (II), diphenylethanes (VI) and (VIII), diphenylpropenones (XI), and diphenylpropanes (XII), are synthesized by simple methods in moderate to good yields.
ChemInform Abstract: Curcumin Analogues as Possible anti‐Proliferative and Antiinflammatory Agents.
Authors: Katsori A.‐M. , Chatzopoulou M. , Dimas K. , Kontogiorgis C. , Patsilinakos A. , Trangas T. , Hadjipavlou‐Litina D. 
Published: September 2011

AbstractFollowing a Claisen—Schmidt condensation between piperidine hydrochloride monohydrate (I) and aryl aldehydes (II) or an aldol condensation between (I) and aryl aldehydes (VI) gives rise to formation of curcumin analogues (III) and (VII).
ChemInform Abstract: Discovery of LASSBio‐772, a 1,3‐Benzodioxole N‐Phenylpiperazine Derivative with Potent α 1A/D‐Adrenergic Receptor Blocking Properties.
Authors: Fraga Carlos A. M. , et al. et al. 
Published: September 2011

AbstractThe target compounds are designed by molecular hybridization of tamsulosin and BMY7378, and synthesized by using classical methodologies.
Prediction of mass transfer coefficients in a pulsed disc and doughnut extraction column
Authors: Torab‐Mostaedi Meisam , Ghaemi Ahad , Asadollahzadeh Mehdi 
Published: September 2011

AbstractA study of the mass transfer performance for a pulsed disc and doughnut extraction column has been presented for a range of operating conditions. The mass transfer performance has been investigated for both directions of mass transfer. This study has examined the mass transfer coefficients which has incorporated the effects of back‐mixing in the continuous phase. The effect of operating variables including pulsation intensity and dispersed and continuous phase velocities on volumetric overall mass transfer coefficient has been investigated. The experiments showed that mixer‐settler, transition and emulsion regimes exist in the column depending on the pulse characteristics. In the present work, effective diffusivity is substituted for molecular diffusivity in the Gröber equation for estimation of overall mass transfer coefficients. The enhancement factor is determined experimentally and there from a single empirical correlation is derived for prediction of enhancement factor in terms of Reynolds number, holdup and Eötvös number for all operating regimes and each mass transfer direction. The experimental results are in very good agreement with the values calculated by the proposed equation. © 2011 Canadian Society for Chemical Engineering
Cyclooxygenase Metabolites in the Kidney
Authors: Harris Raymond C. , Zhang Ming‐Zhi 
Published: September 2011

AbstractIn the mammalian kidney, prostaglandins (PGs) are important mediators of physiologic processes, including modulation of vascular tone and salt and water. PGs arise from enzymatic metabolism of free arachidonic acid (AA), which is cleaved from membrane phospholipids by phospholipase A2activity. The cyclooxygenase (COX) enzyme system is a major pathway for metabolism of AA in the kidney. COX are the enzymes responsible for the initial conversion of AA to PGG2and subsequently to PGH2,which serves as the precursor for subsequent metabolism by PG and thromboxane synthases. In addition to high levels of expression of the “constitutive” rate‐limiting enzyme responsible for prostanoid production, COX‐1, the “inducible” isoform of cyclooxygenase, COX‐2, is also constitutively expressed in the kidney and is highly regulated in response to alterations in intravascular volume. PGs and thromboxane A2exert their biological functions predominantly through activation of specific 7‐transmembrane G‐protein‐coupled receptors. COX metabolites have been shown to exert important physiologic functions in maintenance of renal blood flow, mediation of renin release and regulation of sodium excretion. In addition to physiologic regulation of prostanoid production in the kidney, increases in prostanoid production are also seen in a variety of inflammatory renal injuries, and COX metabolites may serve as mediators of inflammatory injury in renal disease. © 2011 American Physiological Society.Compr Physiol1:1729‐1758, 2011.
Cytodiagnosis of histoplasmosis: Case reports from two patients with variable clinical presentation
Authors: Singh Sunita , Chhabra Sonia , Goyal Ruchi , Garg Shilpa 
Published: September 2011

AbstractHistoplasmosis has emerged as an important opportunistic fungal infection in immunocompromised patients. Histoplasma is a dimorphic fungus that primarily involves lung and the environmental reservoir is soil. Although several cases of histoplasmosis have been reported in India but cytological diagnosis was made in a few cases. We are presenting two cases of histoplasmosis diagnosed on fine‐needle aspiration cytology. In the first case, pulmonary histoplasmosis was diagnosed on transbronchial needle aspiration of lung in a 41‐year‐old immunocompetent male, while second case was of disseminated histoplasmosis in 40‐year‐old immunocompromised female diagnosed on cytology of cervical lymph node. FNAC is a simple, safe, and rapid technique to establish the initial diagnosis, thus promoting early treatment and favorable outcome especially in the immunocompromised patients. Diagn. Cytopathol. 2011; © 2011 Wiley Periodicals, Inc.
Identity and fate of Tbx4‐expressing cells reveal developmental cell fate decisions in the allantois, limb, and external genitalia
Authors: Naiche L.A. , Arora Ripla , Kania Artur , Lewandoski Mark , Papaioannou Virginia E. 
Published: September 2011

AbstractT‐box gene Tbx4 is critical for the formation of the umbilicus and the initiation of the hindlimb. Previous studies show broad expression in the allantois, hindlimb, lung and proctodeum. We have examined the expression of Tbx4 in detail and used a Tbx4‐Cre line to trace the fates of Tbx4‐expressing cells. Tbx4 expression and lineage reveal that various distinct appendages, such as the allantois, hindlimb, and external genitalia, all arise from a single mesenchymal expression domain. Additionally, although Tbx4 is associated primarily with the hindlimb, we find two forelimb expression domains. Most notably, we find that, despite the requirement for Tbx4 in allantoic vasculogenesis, the presumptive endothelial cells of the allantois do not express Tbx4 and lineage tracing reveals that the umbilical vasculature never expresses Tbx4. These results suggest that endothelial lineages are segregated before the onset of vasculogenesis, and demonstrate a role for the peri‐vascular tissue in vasculogenesis. Developmental Dynamics 240:2290–2300, 2011. © 2011 Wiley‐Liss, Inc.