bluuebunny/crossref_metadata_2025_split huggingface dataset:
The spatial and geological characteristics of fault- and paleokarst-controlled carbonate-hosted reservoirs in the Tabei Uplift, Tarim Basin, China
Authors: Sun Qingqing , Holdsworth Robert E. , Fan Tailiang , McCaffrey Kenneth J.W. , Gao Zhiqian , Yang Debin , Wu Pengfei , Gao Shichang 
Published: May 2024

Abstract
Seismic interpretation and characterization of Middle Ordovician carbonates of the northern Tarim Basin in China reveal a series of deep-seated, sub-vertical conjugate strike-slip faults, together with sets of apparently layer-bound fractures striking parallel or orthogonal to the faults. Detailed stratigraphic analysis, well logging response interpretations (including formation microscanner images), coupled with core sample and thin section observations highlight vertical and lateral partitioning of fracturing and dissolution processes. Fracturing and dissolution development are most intense in grain-supported host rocks (grainstones, packstones) deposited in relatively shallow water conditions. Reservoir pore spaces vary systematically from north (Tahe) to south (Shunbei), which can be attributed to their proximity to a major regional angular unconformity with overlying Upper Devonian to Carboniferous sequences. Larger-scale dissolved fracture-cavity reservoirs are developed in the northern Tahe area due to the combined effects of faulting, surface karstification, and river system development close to the base Carboniferous erosion surface. Farther south, where the rocks lie farther from the paleoerosion surface, reservoir space is characterized by smaller, more structurally controlled open cavities bounded by fault slip surfaces, breccias, and open fractures. The observed interactions between paleokarstification intensity, tectonic controls, and host rock lithological layering—and their control over the observed reservoir complexity—are likely to occur in carbonate reservoirs worldwide.
Clinical features of patients with mutations in genes for nanophthalmos
Authors: Li Xueqing , Xiao Hui , Su Yihua , Xiao Xueshan , Li Shiqiang , Lin Shufen , Fang Lei , Sun Wenmin , Wang Panfeng , Hejtmancik James Fielding , Yu Minbin , Chen Liming , Zhang Qingjiong , Liu Xing 
Published: May 2024

Background/AimsTo distinguish the clinical feature of nanophthalmos (NNO) caused by mutations in protease serine 56 (PRSS56), membrane-type frizzled-related protein (MFRP), myelin regulatory factor (MYRF) and transmembrane protein 98 (TMEM98) and to evaluate the association between angle-closure glaucoma (ACG) and NNO.MethodsVariants in those four genes were identified through exome sequencing/whole genome sequencing data, and bioinformatic analysis was conducted to identify pathogenic/likely pathogenic (P/LP) variants. This observational study comprehensively summarised ophthalmological data of 67 patients with NNO from 63 families. Ocular parameters from 68 eyes without surgical treatment were subjected to further analysis.ResultsTotally, 67 patients from 63 families harboured 57 P/LP variants in the four genes, including 30 inPRSS56(47.6%), 23 inMFRP(36.5%), 5 inTMEM98(7.9%) and 5 inMYRF(7.9%). ACG was present in 79.1% of patients. An analysis of ocular parameters from 68 eyes revealed that shorter axial length (AL), lower vitreous-to-AL ratios and severe foveal hypoplasia were associated with variants inPRSS56andMFRP. Uveal effusion was more common in patients withPRSS56variants, while retinitis pigmentosa was frequently observed in patients withMFRPvariants. Patients withMYRFvariants exhibited the thinnest retinal nerve fibre layer thickness. Patients withTMEM98variants had an earlier average onset age of glaucoma.ConclusionVariants inPRSS56andMFRPare the most common genetic cause of NNO. ACG is a severe complication frequently observed in these patients. Earlier onset of ACG is observed in patients with dominant NNO, while foveal hypoplasia is more common in patients with recessive disease. Recognising these features is helpful in clinical care and genetic counselling.
Incidence of thrombocytopenia-associated cerebral venous sinus thrombosis: a population-based study
Authors: Mahadevan Joshua J , Psaltis Peter J , Thrift Amanda G , Kleinig Timothy J 
Published: May 2024

ObjectivesThe identification of SARS-CoV-2 vaccine-induced immune thrombotic thrombocytopenia (VITT) followed the recognition of a hitherto uncommon clinical syndrome frequently associated with cerebral venous sinus thrombosis (CVST), termed ‘thrombosis with thrombocytopenia’ syndrome (TTS). While anecdotally recognised as rare, the background incidence of TTS is unknown. We therefore aimed to investigate the background incidence of CVST with TTS in a large, well-defined population-based CVST cohort.MethodsWe performed an analysis of our previously obtained retrospective population-based cohort of patients with CVST from Adelaide, Australia (2005–2011, comprising an adult population of 953 390) to identify the background incidence of CVST associated with TTS.ResultsAmong 105 people with CVST, the background population-based incidence of TTS-associated CVST was 1.2 per million per year (95% CI 0.5 to 2.4). A single case of a severe CVST VITT-like syndrome with multiorgan thrombosis was identified, occurring 3 weeks postrotavirus infection.ConclusionsIn our population-based study, the background incidence of CVST with associated TTS was very low, and the sole clinically severe case with multiorgan thrombosis occurred following a rotaviral precipitant. Our study establishes a benchmark against which to measure future potential ‘TTS’ clusters and suggests that viruses other than adenovirus may trigger this syndrome.
Increased screen time and its association to migraine and tension-type headache: a cross-sectional investigation among Bangladeshi students
Authors: Roy Simanta , Iktidar Mohammad Azmain , Chowdhury Sreshtha , Pulock Orindom Shing , Pinky Susmita Dey , Sharif Azaz Bin 
Published: May 2024

BackgroundIncreasing prevalence of screens among young people is a notable characteristic of the modern digital era. The study aimed to explore the prevalence and associated factors of migraine headache (MH) and tension-type headache (TTH) among Bangladeshi students continuing online education.MethodsA total of 771 students were selected conveniently and using the quota sampling method. A pretested semistructured and self-administered questionnaire containing the background information, Headache Screening Questionnaire-English Version, Patient Health Questionnaire-9, Speech, Spatial and Qualities of Hearing scale and Insomnia Severity Index was used for data collection. Multivariate logistic regression analysis was conducted to explore the relationship between different headaches and screen use.ResultsThe prevalence of MH, TTH and mixed headache (both MH and TTH) in the study population was 26.07%, 47.08% and 14.75%, respectively. Longer duration of online study (>12 months, adjusted ORs (AORs): 2.83, 95% CI 0 1.00 to 8.00), history of eye problem (AOR: 1.48, 95% CI 1.01 to 2.17), insomnia (AOR: 1.53, 95% CI 1.01 to 2.33) and moderate-to-severe depression (AOR: 2.35, 95% CI 1.55 to 3.56) were significantly associated with migraine headache. Conversely, longer duration of online study (>12 months, AOR: 2.87, 95% CI 1.40 to 5.86), moderate-to-severe depression (AOR=1.47, 95% CI 1.05 to 2.10) and use of multiple devices (AOR<1) for online study were significantly associated with TTH. In addition, longer duration of screen exposure (for >12 months, AOR: 4.56, 95% CI 0.99 to 20.93), moderate-to-severe depression (AOR: 2.25, 95% CI 1.37 to 3.72) and family history of headache (AOR: 2.66, 95% CI 1.65 to 4.29) were associated with mixed headache.ConclusionConsidering the current prevalence of TTH and MH among students and their relationship with screentime, providing health education on the proper use of electronic devices can be a promising strategy in mitigating the negative consequences.
Fibrocartilaginous embolism after mountain cycling: a case report with clinical and radiological follow-up and almost complete recovery
Authors: Hagenkötter Sarah Sophie , Hammami Faten , Hagenkötter Beate 
Published: May 2024

IntroductionFibrocartilaginous embolism (FCE) is a rare spinal cord infarction due to embolism of fibrocartilaginous material with consecutive arterial infarction of the anterior spinal artery. Physical activity with increased axial pressure is the underlying mechanism of the retrograde migration of primarily nucleus pulposus material into the arterial system of the spinal cord. The initial severity of the clinical symptoms is supposed to be a prognostic predictor of recovery and so far, no specific treatment recommendation exists.MethodsWe present a case of spinal cord infarction due to FCE after long and sporty mountain cycling (during 6 hours and 2500 altitude difference) with detailed clinical and radiological follow-up.ResultsThe clinical and radiological follow-up at month 4 showed an unexpected almost complete recovery despite the extensive initial clinical impairment.ConclusionMountain cycling has not yet been described as a specific trigger of FCE with spinal cord infarction. Further observation is necessary to show if the prolonged bent posture and core muscle imbalance in cycling, in addition to the Valsalva manoeuvre during physical effort, may contribute to FCE. It is unknown if prognosis of spinal cord infarction due to FCE differs from other causes of spinal ischaemia and if anticoagulation treatment presents a therapeutic option.
Exploring strategies used following a group-based fatigue management programme for people with multiple sclerosis (FACETS) via the Fatigue Management Strategies Questionnaire (FMSQ)
Authors: Thomas S , Kersten P , Thomas P W , Slingsby V , Nock A , Jones R , Davies Smith A , Galvin K T , Baker R , Hillier C 
Published: May 2024

ObjectivesTo explore cross-sectional patterns of use of fatigue management strategies in people with multiple sclerosis (MS) who had attended a group-based fatigue management programme,Fatigue:ApplyingCognitive behavioural andEnergy effectivenessTechniques to lifeStyle (‘FACETS’). In a multicentre randomised controlled trial (RCT) the FACETS programme was shown to reduce fatigue severity and improve self-efficacy and quality of life.DesignA questionnaire substudy within a RCT involving the self-completed Fatigue Management Strategies Questionnaire (FMSQ). The FMSQ includes: (1) closed questions about the use and helpfulness of fatigue management strategies taught in FACETS and (2) open items about changes to lifestyle, attitudes or expectations, barriers or difficulties encountered and helpful strategies not covered in FACETS.ParticipantsAll had a clinical diagnosis of MS, significant fatigue, were ambulatory and had attended at least 4 of 6 scheduled FACETS sessions.MethodsParticipants (n=72) were posted the FMSQ with a prepaid return envelope 4 months after the end of the FACETS programme.Results82% (59/72) of participants returned the FMSQ. The fatigue management strategies most frequently used since attending FACETS were prioritisation (80%), pacing (78%), saying no to others (78%), grading tasks (75%) and challenging unhelpful thoughts (71%). Adding in those participants who were already using the respective strategies prior to FACETS, the three most used strategies at 4 months were prioritisation (55/59), grading (54/59) and pacing (53/58). Free-text comments illustrated the complex interplay between attitudes/expectations, behaviours, emotions and the environment. Issues related to expectations featured strongly in participants’ comments. Expectations (from self and others) were both facilitators and barriers to effective fatigue management.ConclusionsIndividuals’ comments highlighted the complex, multifaceted nature of fatigue management. Revising expectations and a greater acceptance of fatigue were important shifts following the programme. Findings support the relevance of a cognitive behavioural approach for fatigue management. Booster sessions might be a useful addition to the FACETS programme.Trial registration numberCurrent controlled trialsISRCTN76517470; Results.
Prevalence, genetic and clinical characteristics in first-degree relatives of patients with familial cerebral cavernous malformations in China
Authors: Li Chunwang , Zhuo Lingyun , Kang Yaqing , Liu Penghui , Huang Weilin , Li Qixuan , Ma Ke , Huang Shuna , Lin Xinru , Zhuang Weiheng , Wang Haojie , Chen Darong , Wang Huimin , He Qiu , Gao Zhuyu , Niu Xuegang , Jing Yajun , Yan Lingjun , Gao Bin , Wang Dengliang , Lin Shaowei , Wu Siying , Lin Yuanxiang , Kang Dezhi , Lin Fuxin 
Published: May 2024

ObjectiveThis study aims to investigate the prevalence of familial cerebral cavernous malformations (FCCMs) in first-degree relatives (FDRs) using familial screening, to describe the distribution of initial symptoms, lesion count on cranial MRI and pathogenic gene in patients.MethodsPatients with multiple CCMs who enrolled from the Treatments and Outcomes of Untreated Cerebral Cavernous Malformations in China database were considered as probands and FDRs were recruited. Cranial MRI was performed to screen the CCMs lesions, and whole-exome sequencing was performed to identify CCM mutations. MRI and genetic screening were combined to diagnose FCCM in FDRs, and the results were presented as prevalence and 95% CIs. The Kaplan-Meier (KM) method was used to calculate the cumulative incidence of FCCM.Results33 (76.74%) of the 43 families (110 FDRs) were identified as FCCM (85 FDRs). Receiver operating characteristic analysis revealed three lesions on T2-weighted imaging (T2WI) were the strong indicator for distinguishing probands with FCCM (sensitivity, 87.10%; specificity, 87.50%). Of the 85 FDRs, 31 were diagnosed with FCCM, resulting in a prevalence of 36.5% (26.2%–46.7%). In families with FCCMs, the mutation rates forCCM1,CCM2andCCM3were 45.45%, 21.21% and 9.09%, respectively. Furthermore, 53.13% of patients were asymptomatic, 17.19% were intracranial haemorrhage and 9.38% were epilepsy. The mean age of symptom onset analysed by KM was 46.67 (40.56–52.78) years.ConclusionBased on MRI and genetic analysis, the prevalence of CCMs in the FDRs of families with FCCMs in China was 36.5%. Genetic counselling and MRI screening are recommended for FDRs in patients with more than three CCM lesions on T2WI.
Does anaerobic speed reserve influence post-activation performance enhancement in endurance runners?
Authors: Del Rosso Sebastián , Varela-Sanz Adrián , Tuimil José L. , Boullosa Daniel 
Published: May 2024

We investigated the influence of anaerobic speed reserve (ASR) on post-activation performance enhancement (PAPE). Twenty-two endurance runners and triathletes were evaluated for maximum sprinting speed (MSS) and countermovement jump (CMJ) before (non-fatigued) and after (fatigued) an incremental running test. They were allocated in LASR (low-ASR) and HASR (high-ASR) groups for comparisons between conditions. HASR showed greater CMJ and MSS (both p ≤ 0.005) performances, with enhanced CMJ in fatigued condition ( p ≤ 0.008). Significant correlations were found between ASR, CMJ, and MSS in both conditions ( p ≤ 0.01) for the entire sample, and between ∆CMJ and ∆MSS ( p ≤ 0.001) in LASR. Our results show that ASR profile influences PAPE.
Economic impacts of climate change on forests: a PICUS–LANDIS–CGE modeling approach
Authors: McMonagle Galen , Lantz Van , Taylor Anthony R. , Boulanger Yan , Sharma Chinmay , Withey Patrick , Hennigar Chris 
Published: May 2024

Climate change is expected to alter both forest stand- and landscape-level dynamics through a change in environmental characteristics. While numerous studies have employed models to assess the ecological and/or economic impacts of such changes on forests throughout the world, there is need to further refine such analyses. In this paper, we contribute to this literature by coupling an ecological (PICUS–LANDIS II) modeling framework with an economic (computable general equilibrium) model to better account for the economic impact associated with climate-induced impacts on forest stand- and landscape-level structure and composition dynamics. Applying this framework to a case-study region of New Brunswick, Canada, we estimate that climate change will reduce softwood supply by 16%–73% and impact hardwood supply in the range of −2% to +4% by 2150. The change in wood supply is estimated to reduce the value of the softwood and hardwood forestry and logging sector output by up to 51% and 17%, respectively, by 2150. These sector-level impacts may lead to a 0.08%–0.88% reduction in annual gross domestic product by 2150. The methodological advances established in this study can be used to better inform future forest management and economic plans that aim to lessen both the ecological and economic impact of climate change.
Electrochemical Characterization of Nickel/Gadolinia Doped Ceria Fuel Electrodes under H2/H2O/CO/CO2-Atmospheres
Authors: Esau D. , Grosselindemann C. , Sckuhr S. P. , Kullmann F. , Lindner A. , Liang Z. , Fuchs F. M. , Weber A. 
Published: May 2024

Modelling of the co-electrolysis process requires understanding of the underlying reaction pathways under H2/H2O/CO/CO2-atmospheres. These include the electrochemical steam reduction/hydrogen oxidation, the electrochemical CO2 reduction/CO oxidation and their coupling via the catalytic (reverse) water gas shift reaction ((R)WGS). The assumption of a very fast RWGS and therefore neglectable electrochemical CO2 conversion is commonly used to model the co-electrolysis process. In contrast, previous studies on Ni/GDC fuel electrodes suggest that the electrochemical conversion of CO/CO2 can be present in H2/H2O/CO/CO2-atmospheres. To deconvolute surface-related and non-surface-related processes in the impedance response we present results from a complex variation of operating parameters for process identification by the use of electrochemical impedance spectroscopy and the subsequent impedance analysis by the distribution of relaxation times. A physically meaningful equivalent circuit model, based on a single channel transmission line, is then derived. The model enables quantification of the surface reaction resistance under varied C/H-ratios. From a kinetic analysis it is shown that the electrochemical H2/H2O conversion is dominant for

y

CO

+

y

C

O

2

≤

50% and electrochemical CO/CO2-conversion onsets from

y

CO

+

y

C

O

2

≥ 60%.
HiChIP-Based Epigenomic Footprinting Identifies a Promoter Variant of UXS1 That Confers Genetic Susceptibility to Gastroesophageal Cancer
Authors: Gnanapragasam Ansley , Kirbizakis Eftyhios , Li Anna , White Kyle H. , Mortenson Katelyn L. , Cavalcante de Moura Juliana , Jawhar Wajih , Yan Yifei , Falter Reilly , Russett Colleen , Giannias Betty , Camilleri-Broët Sophie , Bertos Nicholas , Cools-Lartigue Jonathan , Garzia Livia , Sangwan Veena , Ferri Lorenzo , Zhang Xiaoyang , Bailey Swneke D. 
Published: May 2024

Abstract
Genome-wide association studies (GWAS) have identified more than a hundred single nucleotide variants (SNV) associated with the risk of gastroesophageal cancer (GEC). The majority of the identified SNVs map to noncoding regions of the genome. Uncovering the causal SNVs and genes they modulate could help improve GEC prevention and treatment. Herein, we used HiChIP against histone 3 lysine 27 acetylation (H3K27ac) to simultaneously annotate active promoters and enhancers, identify the interactions between them, and detect nucleosome-free regions (NFR) harboring potential causal SNVs in a single assay. The application of H3K27ac HiChIP in GEC relevant models identified 61 potential functional SNVs that reside in NFRs and interact with 49 genes at 17 loci. The approach led to a 67% reduction in the number of SNVs in linkage disequilibrium at these 17 loci, and at 7 loci, a single putative causal SNV was identified. One SNV, rs147518036, located within the promoter of the UDP-glucuronate decarboxylase 1 (UXS1) gene, seemed to underlie the GEC risk association captured by the rs75460256 index SNV. The rs147518036 SNV creates a GABPA DNA recognition motif, resulting in increased promoter activity, and CRISPR-mediated inhibition of the UXS1 promoter reduced the viability of the GEC cells. These findings provide a framework that simplifies the identification of potentially functional regulatory SNVs and target genes underlying risk-associated loci. In addition, the study implicates increased expression of the enzyme UXS1 and activation of its metabolic pathway as a predisposition to gastric cancer, which highlights potential therapeutic avenues to treat this disease.
Significance: Epigenomic footprinting using a histone posttranslational modification targeted 3D genomics methodology elucidates functional noncoding sequence variants and their target genes at cancer risk loci.
Long-term Remissions Following CD20-Directed Chimeric Antigen Receptor–Adoptive T-cell Therapy
Authors: Mo George , Lee Sang Y. , Coffey David G. , Voillet Valentin , Kirsch Ilan R. , Gottardo Raphael , Smythe Kimberly S. , Yeung Cecilia C.S. , Greenbaum Adam , Green Damian J. , Maloney David G. , Till Brian G. 
Published: May 2024

Abstract
Chimeric antigen receptor (CAR) T-cell therapy produces high response rates in refractory B-cell non–Hodgkin lymphoma, but long-term data are minimal to date. In this study, we present long-term follow-up of a pilot trial testing a CD20-targeting third-generation CAR in patients with relapsed B-cell lymphomas following cyclophosphamide-only lymphodepletion. Two of the three patients in the trial, with mantle cell lymphoma and follicular lymphoma, had remissions lasting more than 7 years, though they ultimately relapsed. The absence of B-cell aplasia in both patients suggested a lack of functional CAR T-cell persistence, leading to the hypothesis that endogenous immune responses were responsible for these long-term remissions. Correlative immunologic analyses supported this hypothesis, with evidence of new humoral and cellular antitumor immune responses proximal to clinical response time points. Collectively, our results suggest that CAR T-cell therapy may facilitate epitope spreading and endogenous immune response formation in lymphomas.
Significance: Two of three patients treated with CD20-targeted CAR T-cell therapy had long-term remissions, with evidence of endogenous antitumor immune response formation. Further investigation is warranted to develop conditions that promote epitope spreading in lymphomas.
On the Text and Interpretation of Accius 306-307 Dangel
Authors: Nelis Basil L.P. 
Published: May 2024

Abstract
This article argues that the text of Accius 306-307 Dangel, as transmitted, cannot stand on grammatical grounds. It aims to clarify the use of the word cuiatis, propose an emendation of the text, and suggest a new explanation of the metre of the fragment.
The Decentralised Governance in Kenya: Implications on Citizen Participation in the Local Governance
Authors: Onyalo Paul Otieno 
Published: May 2024

Abstract
This study sought to examine the extent to which decentralisation efforts have affected citizen participation in local governance in Kenya. Survey research designs was employed. 371 questionnaires were administered and 16 interview conducted with key stakeholders. The findings revealed that decentralisation influences citizen participation in devolved Governance. 77.3% of the respondents agreed decentralization had promoted political entrepreneurship while 75% contended that decentralization had influenced citizen participation in development of policies and legislation. Moreover, 57.2% of the respondents felt that citizen participation in decentralized policy-making was high while 69% of the respondents were satisfied that decentralization had made it possible for citizens to participate in county budgeting. Only 49% approved the effectiveness of decentralization in promoting citizen participation in participatory budgeting and planning process. The national and county governments should put in place measures to safeguard the independence of the counties in realizing the objective of citizen participation in governance.