bluuebunny/crossref_metadata_2025_split huggingface dataset:
Functional Polymer Thin Films for Establishing an Effective Electrode Interface in Sulfide‐Based Solid‐State Batteries
Authors: Cho Sungjin , Kim Youson , Song Youngjin , Ryu Jin , Choi Keonwoo , Yang Junyeong , Lee Se‐Hee , Im Sung Gap , Park Soojin 
Published: April 2024

AbstractSulfide solid electrolytes (SSEs) have garnered significant attention for their high ionic conductivity in the development of all‐solid‐state batteries (ASSBs). However, SSEs face challenges due to poor chemical and electrochemical stability, leading to SE decomposition at the anode, which in turn increases internal resistance and reduces cycle performance. Herein, to address this issue, thin polymer layers are applied to prevent direct contact between the SSE and anode using the initiated chemical vapor deposition process. This method facilitates the uniform coating of eight types of polymers with polar functionalities on indium (In) anodes. Half‐cell tests and X‐ray photoelectron spectroscopy analysis reveals that poly(acrylic acid) and poly((perfluorohexyl)ethyl acrylate), containing ─COOH and C─F bonds respectively, effectively stabilized the In/SSE interface. In full cells assembled with polymer‐coated In and LiNi0.8Co0.1Mn0.1O2 (NCM811), capacity retention show remarkable improvement, achieving 64.8% for In@pAA and 50.7% for In@pC6FA after 100 cycles, compared to 29.0% for bare In. This study provides insights into the interaction between polar bonds in polymers and SSEs, potentially bridging a significant knowledge gap resulting from the significant lack of research investigating the relationship between polymers, one of the primary materials commonly used in ASSBs.
Nanomaterials in Antibacterial Photodynamic Therapy and Antibacterial Sonodynamic Therapy
Authors: He Chaonan , Feng Peipei , Hao Mingming , Tang Yun , Wu Xiang , Cui Wenguo , Ma Jingyun , Ke Chunhai 
Published: April 2024

AbstractAntibacterial photodynamic therapy (aPDT) and antibacterial sonodynamic therapy (aSDT) utilize sensitizers (photosensitizers/sonosensitizers) to produce reactive oxygen species (ROS) for antibacterial treatment under the stimulation of light/ultrasound, which have the characteristics of broad‐spectrum antibacterial properties, low drug‐resistance, and effective targeting of infected tissues. Nanomaterials in aPDT/aSDT are primarily used as nano‐sensitizers or nano‐carriers of sensitizers. They enhance the stability and permeability of sensitizers, improve targeting of sensitizers, strengthen photodynamic/sonodynamic properties of sensitizers (modification of sensitizers absorption efficiency and light/ultrasonic response stress by modulation of nanoparticle shape, size, and structure). Also, they improve modifiability of sensitizers (controlling the release rate and time of the sensitizer as needed to optimize the therapeutic effect), enhance programmability and multifunctionality of sensitizers (flexible application of nanotechnology for designing sensitizers with multiple functions, such as drug delivery, targeted therapy, and therapeutic monitoring), and expand possibilities for combination therapies (the nano‐carriers can be loaded with other therapeutic agents, enabling combination therapies). Nanomaterials are expected to further promote the development of aPDT/aSDT and achieve improved antibacterial effects. This review summarizes the progress in nanomaterials in aPDT/aSDT in recent years and based on the current development strategies to provide a theoretical reference for the application of nanomaterials in aPDT/aSDT.
Electronic State‐Modulated Ni4N/Zn3N2 Heterogeneous Nanosheet Arrays Toward Dendrite‐Free and Kinetic‐Enhanced Li‐S Full Batteries
Authors: Ran Qiwen , Liu Jintao , Li Lei , Hu Qiang , Zhao Hongyuan , Komarneni Sridhar , Liu Xingquan 
Published: April 2024

AbstractThe applications of lithium (Li)–sulfur (S) batteries are simultaneously hampered by the unlimited dendritic Li growth and the sluggish redox kinetics of polysulfides (LiPSs). In this work, an electronic state‐modulated Ni4N/Zn3N2 heterogeneous nanosheet arrays is painstakingly fabricated on the surface of carbon cloth (CC@Ni4N/Zn3N2) as an efficient bi‐service host to promote uniform Li deposition and boost efficient LiPSs catalysis. It is found that the electronic structure of Ni4N/Zn3N2 heterostructure is modulated to realize a rational transition metal d‐band center, and its built‐in electric field (BIEF) within the heterointerfaces facilitates the interfacial charge transfer, resulting in low Li deposition/migration energy barrier and efficient LiPSs adsorption/catalytic conversion kinetics. As a result, the as‐prepared CC@Ni4N/Zn3N2‐Li anode can enable the Li||Li symmetrical cells to possess a long‐term lifespan over 500 h even at 10 mA cm−2/20 mAh cm−2, and the as‐assembled LiNi0.8Co0.1Mn0.1O2||CC@Ni4N/Zn3N2‐Li full cell also shows an excellent cycling performance (95.8% capacity retention after 100 cycles). When used for both S and Li loading, the as‐assembled CC@Ni4N/Zn3N2‐S||CC@Ni4N/Zn3N2‐Li full cell exhibits an outstanding cycling stability (744 mAh g−1 after 1000 cycles at 2C). This work highlights the great potential of heterostructures for fabricating ideal bi‐serve hosts for both Li and S electrodes.
CpG and Rutin Co‐Loaded DNA Tetrahedra for Targeted Therapy of Intracerebral Hemorrhage: Synergistic Hematoma Clearance and Neuroinflammation Inhibition
Authors: Wang Jing , Xie Nuli , Lu Shan , Xiao Bo , Ou Yangqin , Li Qingnian , Liu Dexian , Zhou Wenhu 
Published: April 2024

AbstractIntracerebral hemorrhage (ICH) presents a formidable challenge due to its high mortality and disability rates, primarily attributed to cerebral hematoma formation and ensuing neuroinflammation. Swift hematoma removal is paramount for prognosis, yet existing interventions carry risks and limitations. Notably, elevated CD47 expression on hematoma‐associated RBC triggers a “don't eat me” signal, impeding hematoma clearance, while microglial/macrophage erythrophagocytosis exacerbates oxidative stress and the RBC lysate evokes neuroinflammation. To address this conundrum, a multifunctional nanomedicine (TD‐CFR), employing DNA tetrahedra (TD) as a carrier for ICH treatment is introduced. The investigations reveal that CpG enhances the phagocytosis of CD47‐expressing RBC by microglia/macrophages via lipid metabolism modulation. Integration of CpG into TD preserves its pro‐phagocytic efficacy, while TD's double‐stranded region enables efficient encapsulation of Rutin, a potent anti‐inflammatory and antioxidant flavonoid. Capitalizing on disrupted blood‐brain barrier integrity at the hemorrhage site, TD‐CFR achieves robust enrichment within cerebral hematoma post‐intravenous administration, augmented by folate receptor‐mediated targeting of microglia/macrophages. Efficacy assessments in mouse and rabbit ICH models confirm TD‐CFR's therapeutic benefits, including hematoma clearance, neuroinflammation suppression, and brain function restoration. Leveraging TD's high biosafety profile and dual active ingredient loading capacity, the study unveils a promising drug treatment paradigm for ICH.
CT‐Visible Microspheres Enable Whole‐Body In Vivo Tracking of Injectable Tissue Engineering Scaffolds
Authors: Bettini Annalisa , Patrick Peter Stephen , Day Richard M. , Stuckey Daniel J. 
Published: April 2024

AbstractTargeted delivery and retention are essential requirements for implantable tissue‐engineered products. Non‐invasive imaging methods that can confirm location, retention, and biodistribution of transplanted cells attached to implanted tissue engineering scaffolds will be invaluable for the optimization and enhancement of regenerative therapies. To address this need, an injectable tissue engineering scaffold consisting of highly porous microspheres compatible with transplantation of cells is modified to contain the computed tomography (CT) contrast agent barium sulphate (BaSO4). The trackable microspheres show high x‐ray absorption, with contrast permitting whole‐body tracking. The microspheres are cellularized with GFP+ Luciferase+ mesenchymal stem cells and show in vitro biocompatibility. In vivo, cellularized BaSO4‐loaded microspheres are delivered into the hindlimb of mice where they remain viable for 14 days. Co‐registration of 3D‐bioluminescent imaging and µCT reconstructions enable the assessment of scaffold material and cell co‐localization. The trackable microspheres are also compatible with minimally‐invasive delivery by ultrasound‐guided transthoracic intramyocardial injections in rats. These findings suggest that BaSO4‐loaded microspheres can be used as a novel tool for optimizing delivery techniques and tracking persistence and distribution of implanted scaffold materials. Additionally, the microspheres can be cellularized and have the potential to be developed into an injectable tissue‐engineered combination product for cardiac regeneration.
Development of Electrolytes under Lean Condition in Lithium–Sulfur Batteries
Authors: Chen Jianjun , Fu Yuqing , Guo Juchen 
Published: April 2024

AbstractLithium–sulfur (Li–S) batteries stand out as one of the promising candidates for next‐generation electrochemical energy storage technologies. A key requirement to realize high‐specific‐energy Li–S batteries is to implement low amount of electrolyte, often characterized by the electrolyte/sulfur (E/S) ratio. Low E/S ratio aggravates the known challenges for Li–S batteries and introduces new ones originated from the high concentration of polysulfides in limited electrolyte reservoir. In this review, the connections between the fundamental properties of electrolytes and the electrochemical/chemical reactions in Li–S batteries under lean electrolyte condition are elucidated. The emphasis is on how the solvating properties of the electrolyte affect the fate of polysulfides. Built upon the mechanistic analysis, different strategies to design lean electrolytes to improve the overall process of Li–S reactions and Li anode protection are discussed.
Catheter‐Directed Ionic Liquid Embolic Agent for Rapid Portal Vein Embolization, Segmentectomy, and Bile Duct Ablation
Authors: Cevik Enes , Albadawi Hassan , Zhang Zefu , Demirlenk Yusuf , Atar Dila , Keum Chris , Kim Jinjoo , Graf Erin , Gunduz Seyda , Rehman Suliman , Oklu Rahmi 
Published: April 2024

AbstractEmbolic materials currently in use for portal vein embolization (PVE) do not treat the tumor, which poses a risk for tumor progression during the interval between PVE and surgical resection. Here, is developed an ionic‐liquid‐based embolic material (LEAD) for portal vein embolization, liver ablation, and drug delivery. LEAD is optimized and characterized for diffusivity, X‐ray visibility, and cytotoxicity. In the porcine renal embolization model, LEAD delivered from the main renal artery reached vasculature down to 10 microns with uniform tissue ablation and delivery of small and large therapeutics. In non‐survival and survival porcine experiments, successful PVE is achieved in minutes, leading to the expected chemical segmentectomy, and delivery of a large protein drug (i.e., Nivolumab) with LEAD. In cholangiocarcinoma mouse tumor models and in ex vivo human tumors, LEAD consistently achieved an effective ablation and wide drug distribution. Furthermore, various strains of drug‐resistant patient‐derived bacteria showed significant susceptibility to LEAD, suggesting that LEAD may also prevent infectious complications resulting from tissue ablation. With its capabilities to embolize, ablate, and deliver therapeutics, ease of use, and a high safety profile demonstrated in animal studies, LEAD offers a potential alternative to tumor ablation with or without PVE for FLR growth.
Long‐Term Immersion Study for Durability of Interconnected Micropatterned Surfaces with Sustained Water Repellency
Authors: Park Seo Rim , Oh Seungmin , Kim Woo Young , Kim Do Hyeog , Lee Sang Hoon , Shin Seungwoo , Choi Su Hyun , Kwon Sin , Lee Heedoo , Kim Seok , Cho Young Tae 
Published: April 2024

AbstractThe sustained water repellency of interconnected micropatterned surfaces is explored over an extended duration, with a focus on their resilience during a 90‐day water‐immersion test. Initially, the microstructure surfaces exhibit high water repellency, a characteristic of the Cassie–Baxter state. However, subsequent detailed temporal analyses reveal varying responses depending on the structural topology. The interconnected micropatterned surfaces exhibit remarkable long‐term resistance to water; this is attributed to the formation of large and stable air pockets enabled by their unique microcavity structures. In comparison, hierarchical microcavity surfaces with micropillars exhibit a notable decrease in water repellency, as evidenced by reduced contact angles, suggesting a transition to a wetting state owing to the emergence of surface hydrophilicity during long‐term water exposure. This study demonstrates the importance of stable air‐pocket effects, particularly in applications where the long‐term stability of liquid repellency is critical, and suggests the role of interconnected structures in maintaining water repellency over time.
Luminescence of Lanthanide Complexes in Mesoporous Silica Matrices: A Textbook Example of Tris‐Dipicolinate Europium Complex Adsorbed in SBA‐15
Authors: Balogh Cristina M. , N'Dala‐Louika Isis , Suleimanov Iurii , Pons Anaïs , Jouffrieau Matthias , Camp Clément , Chaput Frédéric , Veyre Laurent , Thieuleux Chloé , Maury Olivier , Riobé François 
Published: April 2024

AbstractThe incorporation of luminescent lanthanide complexes in inorganic matrices opens appealing possibilities in the rational upstream conception of new luminescent materials with easier recyclability. In this regard, the influence of SBA‐15 mesoporous silica, as a host matrix, on the photophysical properties of europium‐trisdipicolinate cesium salt is investigated. The lanthanide complex can be completely and reversibly adsorbed on the silica, using incipient wetness impregnation (IWI) in WATER, without the need of anchoring groups or covalent bonding on the silica surface. This specific procedure allows the homogeneous dispersion of the lanthanide complex into the host silica matrix. Appropriately assessing the photophysical properties of the targeted luminescent material proved remarkably challenging, demanding utmost caution, particularly due to the strong scattering of the mesoporous matrices. Additionally, while the observations confirm an important increase of luminescence lifetimes of lanthanide complexes upon integration into these mediums, this variation is attributed to the differing refractive indexes and not to specific surface interactions or confinement effect. Indeed, it appeared that previous literature precedents depicted erroneous exhalations of the complexes intrinsic quantum yield due to the repeated use of erroneous refractive index values. In the meantime, the luminance of these materials under UV irradiation improves drastically in comparison to what is obtained with the physical dispersion of micro‐crystals of the lanthanide complex onto silica. It is demonstrated that this improvement is due to a reduced inner filter effect in the adsorbed samples. In this regard, IWI of lanthanide complexes in the mesoporous matrices method could be of interest in the development of recyclable emitting layers, less demanding in terms of emitter quantity.
Topological broadband invisibility
Authors: Pan Yuang , Zhang Li , Chen Xuan , Chen Fujia , Han Ning , Chen Qiaolu , Chen Hongsheng , Yang Yihao 
Published: April 2024

AbstractWhen an electromagnetic wave is incident onto an object, the scattering from the object leads to its exposure. An invisibility cloak can bend the electromagnetic wave around the object with phase velocities exceeding the light speed in free space, which seems only possible over a narrow bandwidth, as manifested in the existing approaches, such as transformation optics and scattering cancellation. Here, it is experimentally demonstrated that this bandwidth limitation can be overcome by strategically positioning objects at topological nodes, characterized by minimal electromagnetic field amplitudes and indeterminate phases. This is accomplished using all‐dielectric photonic crystal slabs, which are engineered to exhibit a pair of topological nodes at fixed planes across an extensive bandwidth. This bandwidth expansion is facilitated not by resonance, but by the enforcement of mirror and time‐reversal symmetry. These findings thus introduce a novel topological paradigm for the broadband invisibility devices.
Lithium‐Lanthanide Heterometallic Organic Frameworks with Near‐Unity Photoluminescence Quantum Yields for Single‐Composition White‐Light Emission and Fluorescent Sensing on Nitrobenzene
Authors: Zhang Wei , Wang En‐Ting , Li Xinhao , Huang Weixin , Sun Yakun , Liu Zheyuan , Zheng Wei , Yi Xiaodong , Li Xin‐Xiong , Li Lingyun , Yu Yan 
Published: April 2024

AbstractLanthanide ion contained metal–organic frameworks (MOFs) have garnered significant attention in the fields of solid‐state lighting and chemical sensing due to their porous structure and distinctive optical properties. However, they also present challenges because of the limited photoluminescence (PL) intensity resulting from the parity‐forbidden f–f transitions of lanthanide ions. Herein, the study reports a new heterometallic MOFs Ln3Li2L4 (Li‐Ln‐MOF, Ln = Y, Eu, Tb and Dy, L = deprotonated 1,3,5‐tris(4‐carboxyphenyl)benzene) with a Brunauer‐Emmett‐Teller (BET) surface area of 774.1 m2/g. The porous crystal structure of Li‐Ln‐MOF is characterized by three kinds of channels interpenetrating with each other. By employing ligand alternation and lanthanide ion alloying strategies, Li‐Y1‐xEux‐MOF1 crystal isostructural with Li‐Ln‐MOF is synthesized by using 2,4,6‐tris(4‐carboxyphenyl)‐1,3,5‐triazine (H3TATB) as ligand. The Li‐Y0.7Eu0.3‐MOF1 crystal excels in the comprehensive performance with a BET surface area of 858.8 m2 g−1 and a near‐unity PL quantum yield. The time density functional theory and natural transition orbitals calculations unravel that the outstanding optical properties Li‐Y0.7Eu0.3‐MOF1 originates from the charge transfer between TATB3− and Eu3+. Benefiting from the excellent comprehensive performance of Li‐Y1‐xEux‐MOF1, the study reveals their potentials as single‐composition white‐light emission and fluorescent sensing probe for the detection of nitrobenzene.
Hybrid PV Systems – Optimizing CPV and SiPV Ratio to Increase Sustainability of Hydrogen Production
Authors: Boulaire Fanny A. , Love Jonathan G. , Mohammadshahi Shahrzad S. , Mackinnon Ian D.R. 
Published: April 2024

AbstractThis paper establishes the concept of hybrid PV systems where the ratio of different photovoltaic (PV) technologies is optimized so that their combined output profile best matches user requirements. The method is presented and applied to a case study where a two‐axis tracking concentrating photovoltaic (CPV) and a single‐axis silicon photovoltaic (SiPV) system installed at a sub‐tropical location in Australia, are to power the production of hydrogen by electrolysis. The analysis quantifies the performance of the PV systems from data gathered at the site and reveals the complementarity of these two systems in their output at different timescales. An optimization problem is then defined that seeks the optimal ratio of CPV and SiPV to achieve high annual power output and, importantly, a good match between power supply and demand profiles. The benefits of this approach are illustrated for a green hydrogen power‐to‐gas‐to‐power plant under two operating modes. For this case study, the optimal PV ratio of 0.33CPV: 0.67SiPV leads to reduced dependence on the electricity grid, and a maximum guaranteed minimal take‐up of hydrogen over all months in a year. Overall, the sustainability of the plant is increased without the need for additional storage, and therefore additional resources.
Antibody and siRNA Nanocarriers to Suppress Wnt Signaling, Tumor Growth, and Lung Metastasis in Triple‐Negative Breast Cancer
Authors: Dang Megan N. , Suri Sejal , Li Kejian , Gomez Casas Carolina , Stigliano Gianna , Riley Rachel S. , Scully Mackenzie A. , Hoover Elise C. , Aboeleneen Sara B. , Kramarenko George C. , Day Emily S. 
Published: April 2024

AbstractThe paucity of targeted therapies for triple‐negative breast cancer (TNBC) causes patients with this aggressive disease to suffer a poor clinical prognosis. A promising target for therapeutic intervention is the Wnt signaling pathway, which is activated in TNBC cells when extracellular Wnt ligands bind overexpressed Frizzled7 (FZD7) transmembrane receptors. This stabilizes intracellular β‐catenin proteins that in turn promote transcription of oncogenes that drive tumor growth and metastasis. To suppress Wnt signaling in TNBC cells, this work develops therapeutic nanoparticles (NPs) functionalized with FZD7 antibodies and β‐catenin small interfering RNAs (siRNAs). The antibodies enable TNBC cell specific binding and inhibit Wnt signaling by locking FZD7 receptors in a ligand unresponsive state, while the siRNAs suppress β‐catenin through RNA interference. Compared to NPs coated with antibodies or siRNAs individually, NPs coated with both agents more potently reduce the expression of several Wnt related genes in TNBC cells, leading to greater inhibition of cell proliferation, migration, and spheroid formation. In two murine models of metastatic TNBC, the dual antibody/siRNA nanocarriers outperformed controls in terms of inhibiting tumor growth, metastasis, and recurrence. These findings demonstrate suppressing Wnt signaling at both the receptor and mRNA levels via antibody/siRNA nanocarriers is a promising approach to combat TNBC.
Nanosponge for Iron Chelation and Efflux: A Ferroptosis‐Inhibiting Approach for Myocardial Infarction Therapy
Authors: Lv Qingbo , Lin Jun , Huang He , Ma Boxuan , Li Wujiao , Chen Jiawen , Wang Meihui , Wang Xiaoyu , Fu Guosheng , Xiao Yun 
Published: April 2024

AbstractMyocardial infarction (MI), a consequence of coronary artery occlusion, triggers the degradation of ferritin, resulting in elevated levels of free iron in the heart and thereby inducing ferroptosis. Targeting myocardial ferroptosis through the chelation of excess iron has therapeutic potential for MI treatment. However, iron chelation in post ischemic injury areas using conventional iron‐specific chelators is hindered by ineffective myocardial intracellular chelation, rapid clearance, and high systemic toxicity. A chitosan‐desferrioxamine nanosponge (CDNS) is designed by co‐crosslinking chitosan and deferoxamine through noncovalent gelation to address these challenges. This architecture facilitates direct iron chelation regardless of deferoxamine (DFO) release due to its sponge‐like porous hydrogel structure. Upon cellular internalization, CDNS can effectively chelate cellular iron and facilitate the efflux of captured iron, thereby inhibiting ferroptosis and associated oxidative stress and lipid peroxidation. In MI mouse models, myocardial injection of CDNS promotes sustainable retention and the suppression of ferroptosis in the infarcted heart. This intervention improves cardiac function and alleviates adverse cardiac remodeling post‐MI, leading to decreased oxidative stress and the promotion of angiogenesis due to ferroptosis inhibition by CDNS in the infarcted heart. This study reveals a nanosponge‐based nanomedicine targeting myocardial ferroptosis with efficient iron chelation and efflux, offering a promising MI treatment.