bluuebunny/crossref_metadata_2025_split huggingface dataset:
Studies on inherently radiopaque acrylate copolymers for biomedical applications
Authors: Dawlee S. , Jayabalan M. 
Published: January 2012

AbstractPoly(glycidyl methacrylate‐co‐ethyl methacrylate) and poly(glycidyl methacrylate‐co‐butyl methacrylate) random copolymers (with 50–50 mol % of monomers) were made radiopaque by grafting iodine moieties through the ring opening reaction of the epoxy groups. The percentage weight of grafted iodine in the copolymers was found to be as high as 19%. The iodinated copolymers showed higher glass transition temperature and thermal stability in comparison with the parent copolymers. Iodinated copolymer of poly(glycidyl methacrylate‐co‐ethyl methacrylate) has improved glass transistion temperature than iodinated poly(glycidyl methacrylate‐co‐butyl methacrylate). Radiographic analysis of these iodinated copolymers showed excellent radiopacity. The in vitro cytotoxicity tests revealed cytocompatibility with cells. These radiopaque copolymers are expected to find application as dental and orthopedic cements. © 2012 Wiley Periodicals, Inc. J Appl Polym Sci, 2012
Miscibility and crystallization behavior of poly(ethylene‐co‐vinylalcohol)/poly(maleic anhydride‐alt‐ethylene) blend
Authors: Aouak Taieb , AlArifi Abdullah Saad , Ouladsmane Mohamed 
Published: January 2012

AbstractThe miscibility of poly(vinylalcohol‐co‐ethylene) (PEVA) with poly(ethylene‐alt‐maleic anhydride) (PEMAH) blends was investigated over a wide range of compositions by viscosimetry and DSC analyses using Krigbaum–Wall and Kwei approaches. The results revealed that the blends were completely miscible in all proportions due to the specific interactions between the hydroxyl groups of PEVA and the carbonyl groups of PEMAH. From Nishi equation, the interaction parameter of Flory was found to be −0.89. The nonisothermal crystallization behavior and kinetics of this system were also investigated and compared with those of the pure PEVA. There were strong dependencies of the degree of crystallinity (XT), peak crystallization temperature (Tp), half time of crystallization (t1/2), and Ozawa exponent (m) on PEMAH content and cooling rate. The crystallization activation energy (Ec) that was calculated from Kissinger model increased with increasing PEMAH composition in the blend. © 2012 Wiley Periodicals, Inc. J Appl Polym Sci, 2012
BNC1 is required for maintaining mouse spermatogenesis
Authors: Zhang Xiaohong , Chou Weichin , Haig‐Ladewig Lisa , Zeng Wenxian , Cao Wenlei , Gerton George , Dobrinski Ina , Tseng Hung 
Published: January 2012

AbstractBasonuclin (BNC1) is a zinc finger protein expressed primarily in gametogenic cells and proliferative keratinocytes. Our previous work suggested that BNC1 is present in spermatogonia, spermatocytes, and spermatids, but absent in the Sertoli cells. BNC1′s role in spermatogenesis is unknown. Here, we show that BNC1 is required for the maintenance of spermatogenesis. Bnc1‐null male mice were sub‐fertile, losing germ cells progressively with age. The Bnc1‐null seminiferous epithelia began to degenerate before 8 weeks of age and eventually became Sertoli cell‐only. Sperm count and motility also declined with age. Furthermore, Bnc1 heterozygotes, although fertile, showed a significant drop in sperm count and in testis weight by 24 weeks of age, suggesting a dosage effect of Bnc1 on testis development. In conclusion, our data demonstrate for the first time BNC1′s essential role in maintaining mouse spermatogenesis. genesis 50:517–524, 2012. © 2012 Wiley Periodicals, Inc.
Comparison of limited‐volume perioperative high‐dose‐rate brachytherapy and wide‐field external irradiation in resected head and neck cancer
Authors: Gaztañaga Miren , Pagola María , Cambeiro Mauricio , Ruiz Maria E. Rodriguez , Aristu Javier , Montesdeoca Néstor , Alcalde Juan , Martínez‐Monge Rafael 
Published: January 2012

AbstractBackgroundThis study aimed to test the safety of using perioperative high‐dose‐rate brachytherapy (PHDRB) in resected head and neck cancer.MethodsFrom 2000 to 2008, 97 patients received PHDRB after complete macroscopic resection. Group 1 (previously irradiated patients) received 32 to 40 Gray (Gy) of PHDRB in 8 to 10 twice‐daily (bid) treatments (R0–R1 resections). Group 2 (unirradiated patients) received 16 to 24 Gy of PHDRB in 4 to 6 bid treatments (R0–R1 resections) followed by external beam irradiation (EBRT) of 45 Gy/25 daily fractions ± concomitant chemotherapy.ResultsThe median follow‐up was 4.3 years. The cumulative hazard of 2‐year grade ≥ 3 complications in group 1 was 45.9%, and the rate of grade ≥ 3 complications in group 2 was 24.6%. Actuarial locoregional control at 2 and 5 years for group 1 was 60.9% and for group 2, 84.1% and 79.4%.ConclusionsComplications and locoregional failure rates were similar to those reported in the reference standards despite a much smaller treatment volume. © 2012 Wiley Periodicals, Inc. Head Neck, 2012
Minor salivary gland malignancies in the pediatric population
Authors: Galer Chad , Santillan Alfredo A. , Chelius Daniel , Huh Winston , El‐Naggar Adel , Hanna Ehab. , Weber Randal S. , Kupferman Michael E. 
Published: January 2012

AbstractBackgroundMinor salivary gland malignancies in children are rare and data on treatment and outcomes are limited.MethodsA retrospective chart review of all pediatric patients with the pathologic diagnosis of minor salivary gland malignancy at a tertiary care cancer hospital was used to conduct this review.ResultsFrom 1952 to 2006, 35 children with minor salivary gland cancers were treated at The University of Texas MD Anderson Cancer Center. Mean age was 15.2 +/‐ 2.9 years with a slight female predominance. Recurrence occurred in 4 patients and was significantly associated with positive margins, advanced stage, and high histologic grade. Overall survival (OS) and disease‐specific survival (DSS) were 89.3% and 88.4%, respectively, at 5 years. Advanced stage, positive margins, and high grade were associated with adverse survival.ConclusionMinor salivary gland malignancies in children are rare. Surgical resection with clear margins yields excellent outcomes in patients with low‐intermediate grade and early stage tumors. Patients with high‐grade malignancies do poorly despite multimodality therapy. © 2012 Wiley Periodicals, Inc. Head Neck, 2012
Volumetric change of human papillomavirus–related neck lymph nodes before, during, and shortly after intensity‐modulated radiation therapy
Authors: Sanguineti Giuseppe , Ricchetti Francesco , Wu Binbin , Agrawal Nishant , Gourin Christine , Agbahiwe Harold , Marur Shanthi , Clemente Stefania , McNutt Todd , Forastiere Arlene 
Published: January 2012

AbstractBackgroundTo assess volumetric changes of human papillomavirus (HPV)‐related lymph nodes (LN) before, during, and after a course of intensity‐modulated radiation therapy (IMRT) ± chemotherapy.MethodsEach “pathologic” LN (≥1 cm) was contoured on the available diagnostic/planning CTs before, during each week, and after treatment.ResultsSeventy‐nine LNs in 50 patients were identified. Beyond the first week of treatment, 3 patterns of LN change were recorded: consistently shrinking LN (n = 33; 41.8%), inconsistently shrinking LN with temporary enlargement limited to the first week (n = 14; 17.7%), or also during the subsequent weeks (n = 32; 40.5%). Nodal density at planning is highly predictive of group assignment, with a larger mean density for consistently over inconsistently shrinking LNs (p = .009). Also, this grouping predicts the response at the end of treatment.ConclusionHPV‐related LN behavior during IMRT is extremely variable but somewhat predictable on the basis of nodal density at planning. © 2012 Wiley Periodicals, Inc. Head Neck, 2012
Molecular targeting agents in the context of primary chemoradiation strategies
Authors: Laban Simon , Wang Chia Jung , Münscher Adrian , Tribius Silke , Schafhausen Philippe , Knecht Rainald 
Published: January 2012

AbstractBackgroundDemands for organ preservation and increasing knowledge in molecular tumor biology have lead to the development of molecular targeting agents. These substances have also been incorporated into concomitant and sequential chemoradiation protocols.MethodsThis study was conducted using a systematic literature review.ResultsIn head and neck squamous cell carcinoma (HNSCC), the inhibition of epidermal growth factor receptor (EGFR) signaling as a central step in carcinogenesis, progression, and metastasis is the predominant approach. Although EGFR targeting substances are commonly used, the specific influence of molecular targeting therapies on patient outcome remains unclear. In this review, results from recent clinical trials in the area of primary chemoradiation in the combination with EGFR targeting agents are discussed.ConclusionEncouraging results from recent trials need to be confirmed in larger patient cohorts and cost‐effectiveness analyses have to be undertaken. Phase III studies need to confirm these results before, time and again, new phase II studies are initiated. © 2012 Wiley Periodicals, Inc. Head Neck, 2013
Pattern and predictive factors of regional lymph node metastasis in papillary thyroid carcinoma: A prospective study
Authors: Nam Inn Chul , Park Jun Ook , Joo Young Hoon , Cho Kwang Jae , Kim Min Sik 
Published: January 2012

AbstractBackgroundMost of the reports about lymph node (LN) metastasis in papillary thyroid carcinoma (PTC) are retrospective studies.MethodsWe prospectively evaluated the pattern and predictive factors of LN metastasis of 176 patients with PTC who underwent total thyroidectomy and bilateral central LN dissection with or without therapeutic lateral LN dissection.ResultsIpsilateral central LNs were involved even in early T classification, and contralateral central LNs were infrequently involved even in late T classification. Most of the lateral LN metastases were in levels II, III, and IV. Male sex was predictive of LN metastasis. Ipsilateral central LN metastasis and central LN metastasis were associated with contralateral central LN metastasis and lateral LN metastasis, respectively.ConclusionsIpsilateral central neck dissection is recommended for all PTC patients. Careful inspection for LN metastasis should be performed when evaluating male patients with PTC, and if central LNs are involved, carefully inspect lateral LNs. © 2012 Wiley Periodicals, Inc. Head Neck, 2013
CO2 laser surgery in elderly patients with glottic carcinoma: Univariate and multivariate analyses of results
Authors: Lucioni Marco , Bertolin Andy , Rizzotto Giuseppe , Accordi Daria , Giacomelli Luciano , Marioni Gino 
Published: January 2012

AbstractBackgroundThere are limited data on the role of laser‐assisted surgery for early glottic cancer in elderly patients.MethodsThis retrospective study was conducted on a series of 130 consecutive cases of early glottic carcinoma occurring in elderly patients (>65 years old) treated with CO2 laser surgery.ResultsThe overall and disease‐specific survival rates were 87.7% and 99.2%, respectively. The rates of local disease control after primary laser surgery, ultimate local control with laser alone, and laryngeal preservation were 84.6%, 93.8%, and 96.9%, respectively. A shorter disease‐free survival (DFS) was associated with the involvement of 1 or more specific laryngeal regions (arytenoids, ventricle, anterior commissure, vocal muscle, subglottis) (p = .01) and the status of the surgical margins (p = .002); on multivariate analysis, only the latter remained prognostically significant vis‐à‐vis the DFS (p = .002).ConclusionsEven in elderly patients with early glottic carcinoma, endoscopic laser surgery is an effective treatment. © 2012 Wiley Periodicals, Inc. Head Neck, 2012
Distant metastases from cutaneous squamous cell carcinoma—analysis of AJCC stage IV
Authors: Brunner Markus , Veness Michael J. , Ch'ng Sydney , Elliott Michael , Clark Jonathan R. 
Published: January 2012

AbstractBackgroundThe seventh edition of the American Joint Committee on Cancer (AJCC) Staging Manual introduced a more detailed system to stage regional lymph node metastases for disease with cutaneous squamous cell carcinoma (SCC). The purpose of this study was to determine if the inclusion of disease staged N2 and N3 together with disease staged M1 is an appropriate grouping within stage IV.MethodsA retrospective multicenter analysis was conducted of 603 patients with metastatic cutaneous SCC to compare survival data for regional (N2 and N3) versus distant metastases.ResultsDisease specific survival (DSS) and overall survival (OS) were much poorer for patients with distant disease compared to those with different stages of regional disease. After 5 years, only 25% of patients with N2 disease and 35% of patients with N3 disease died from their cancer compared with 89% of patients with distant metastases.ConclusionOur results indicate that in cutaneous SCC, stage IV represents a very heterogeneous group. Therefore, N2 and N3 disease should not be grouped with M1 together within AJCC stage IV. © 2012 Wiley Periodicals, Inc. Head Neck, 2013
Improved outcomes in buccal squamous cell carcinoma
Authors: Lin Chun–Shu , Jen Yee–Min , Kao Woei–Yau , Ho Ching–Liang , Dai Ming–Shen , Shih Chia–Lin , Cheng Jen–Chan , Chang Ping–Ying , Huang Wen–Yen , Su Yu–Fu 
Published: January 2012

AbstractBackgroundThe treatment results of buccal squamous cell carcinoma before and after 2002 were compared.MethodsTwo hundred forty‐five patients with buccal cancer who underwent curative treatment were retrospectively reviewed.ResultsThe 5‐year overall survival rate was 30.0% before 2002 and 53.5% after 2002 (p = .004). On multivariate analysis, T classification, surgical margins, and treatment modality significantly affected overall survival, and N classification and histologic grade had trends to affect it. Invasion depth had a trend to influence locoregional control. For patients with early‐stage disease without adverse factors, the locoregional control was similar between surgery alone group and surgery + radiotherapy group.ConclusionThe survival of patients with buccal cancer was improved after 2002, which represented the start of intensity‐modulated radiotherapy (IMRT) in our institute. Ipsilateral neck alone irradiation was recommended for T1‐2N0‐1 and small T3N0 disease, and bilateral neck irradiation could be reserved for advanced disease. © 2012 Wiley Periodicals, Inc. Head Neck, 2013
Relation between the dimensions and intraluminal pressure of the pharyngoesophageal segment and tracheoesophageal voice and speech proficiency
Authors: Takeshita Telma Kioko , Zozolotto Henrique Ceretta , Ribeiro Eduardo Alvarez , Ricz Hilton , de Azevedo‐Marques Paulo Mazzoncini , Dantas Roberto Oliveira , Aguiar‐Ricz Lílian 
Published: January 2012

AbstractBackgroundThe objective of the present study was to relate the dimensions and the intraluminal pressure of the pharyngoesophageal segment (PES) to the voice and speech proficiency of total laryngectomees with a tracheoesophageal prosthesis (TEP).MethodsTwenty total laryngectomees with secondary TEP insertion underwent evaluation of voice and speech, manometry, and videofluoroscopy.ResultsMost laryngectomees (65%) were moderate speakers. The poorer speakers presented a lower intraluminal pressure in the PES at rest (4.44 mmHg) and a higher value (40.46 mmHg) during phonation. Good speakers presented a significant difference in the anteroposterior distance between prominence of the PES and the posterior pharyngeal wall (PPES‐PPW) in the rest (6.09 mm) to phonation (3.24 mm).ConclusionsThe poorer speakers presented a lower intraluminal pressure in the PES at rest and a higher value during phonation compared with moderate speakers. Good speakers showed a significant difference in the PPES‐PPW dimension. © 2012 Wiley Periodicals, Inc. Head Neck, 2013
Coupled‐cluster theory for the polarizable continuum model. III. A response theory for molecules in solution
Authors: Cammi R. 
Published: January 2012

AbstractA coupled‐cluster (CC) response functions theory for molecular solutes described with the framework of the polarizable continuum model (PCM) is presented. The theory is an extension to the dynamical molecular properties of the PCM‐CC analytic derivatives recently proposed for the calculation of static molecular properties (Cammi, Jr Chem Phys 2009, 131, 164104). The theory is presented for linear and quadratic response functions, and the operative expressions of these response functions can accurately account for the nonequilibrium solvation effects. The excitation energies and transition moments of the solvated chromophores have been determined from the linear response functions. Accurate expressions for gradients of excitation energies for the evaluation of the excited state properties have been also discussed. © 2012 Wiley Periodicals, Inc. Int J Quantum Chem, 2012
Direct detection of additives and degradation products from polymers by liquid extraction surface analysis employing chip‐based nanospray mass spectrometry
Authors: Paine Martin R. L. , Barker Philip J. , Maclauglin Shane A. , Mitchell Todd W. , Blanksby Stephen J. 
Published: January 2012

RATIONALEPolymer‐based surface coatings in outdoor applications experience accelerated degradation due to exposure to solar radiation, oxygen and atmospheric pollutants. These deleterious agents cause undesirable changes to the aesthetic and mechanical properties of the polymer, reducing its lifetime. The use of antioxidants such as hindered amine light stabilisers (HALS) retards these degradative processes; however, mechanisms for HALS action and polymer degradation are poorly understood.METHODSDetection of the HALS TINUVIN®123 (bis(1‐octyloxy‐2,2,6,6‐tetramethyl‐4‐piperidyl) sebacate) and the polymer degradation products directly from a polyester‐based coil coating was achieved by liquid extraction surface analysis (LESA) coupled to a triple quadrupole QTRAP® 5500 mass spectrometer. The detection of TINUVIN®123 and melamine was confirmed by the characteristic fragmentation pattern observed in LESA‐MS/MS spectra that was identical to that reported for authentic samples.RESULTSAnalysis of an unstabilised coil coating by LESA‐MS after exposure to 4 years of outdoor field testing revealed the presence of melamine (1,3,5‐triazine‐2,4,6‐triamine) as a polymer degradation product at elevated levels. Changes to the physical appearance of the coil coating, including powder‐like deposits on the coating's surface, were observed to coincide with melamine deposits and are indicative of the phenomenon known as polymer 'blooming'.CONCLUSIONSFor the first time, in situ detection of analytes from a thermoset polymer coating was accomplished without any sample preparation, providing advantages over traditional extraction‐analysis approaches and some contemporary ambient MS methods. Detection of HALS and polymer degradation products such as melamine provides insight into the mechanisms by which degradation occurs and suggests LESA‐MS is a powerful new tool for polymer analysis. Copyright © 2012 John Wiley & Sons, Ltd.
Correcting for nonlinearity effects of continuous flow isotope ratio mass spectrometry across a wide dynamic range
Authors: Kornfeld Ari , Horton Travis W. , Yakir Dan , Turnbull Matthew H. 
Published: January 2012

RATIONALEEnvironmental and biological investigations may require samples that vary over a wide range of concentrations and isotope ratios, making measurements using continuous flow isotope ratio mass spectrometry (CF‐IRMS) problematic due to nonlinear signal response. We therefore developed a mathematical approach for correcting nonlinearities over a wide range of sample concentrations and actual δ values.METHODSDilution series for two standards were prepared in septum‐capped vials and introduced into the mass spectrometer via the standard sampling pathway. Parameters for a nonlinear signal correction were determined by regression on measured isotope ratio vs. both signal strength and actual isotope ratio. We further extended the dynamic range by adjusting the position of an open split based on analyte concentration. Effects of the open split setting required additional mathematical correction.RESULTSThe nonlinearities were corrected over a 100‐fold range of sample concentrations and across a 600‰ change in isotope ratios (for δO2/N2 values). The precision, measured as standard deviation, across the upper 90% of the concentration range was ±0.08‰, ±0.05‰, and ±2.6‰ for δ18O, δ15N, and δO2/N2 values, respectively; the precision across the lower 10% of the range was ±0.22‰, ±0.07‰, and ±7.6‰, respectively. In all cases the linearity correction represented only a small fraction of these precision values.CONCLUSIONSThe empirical correction described here provides a relatively simple yet effective way to increase the usable signal range for CF‐IRMS applications. This improvement in dynamic range should be especially helpful for environmental and biological field studies, where sampling methods may be constrained by external factors. Copyright © 2012 John Wiley & Sons, Ltd.
Holography for Einstein-Maxwell-dilaton theories from generalized dimensional reduction
Authors: Goutéraux Blaise , Smolic Jelena , Smolic Milena , Skenderis Kostas , Taylor Marika 
Published: January 2012

AbstractWe show that a class of Einstein-Maxwell-Dilaton (EMD) theories are re- lated to higher dimensional AdS-Maxwell gravity via a dimensional reduction over com- pact Einstein spaces combined with continuation in the dimension of the compact space to non-integral values (‘generalized dimensional reduction’). This relates (fairly complicated) black hole solutions of EMD theories to simple black hole/brane solutions of AdS-Maxwell gravity and explains their properties. The generalized dimensional reduction is used to infer the holographic dictionary and the hydrodynamic behavior for this class of theories from those of AdS. As a specific example, we analyze the case of a black brane carrying a wave whose universal sector is described by gravity coupled to a Maxwell field and two neutral scalars. At thermal equilibrium and finite chemical potential the two operators dual to the bulk scalar fields acquire expectation values characterizing the breaking of con- formal and generalized conformal invariance. We compute holographically the first order transport coefficients (conductivity, shear and bulk viscosity) for this system.
Influence of a triazine derivative-based biocide on microbial biofilms of cutting fluids in contact with different substrates
Authors: Lucchesi Eliane G , Eguchi Sílvia Y , Moraes Ângela M 
Published: January 2012

Abstract
Although biofilms are often associated with hospital infection problems owing to their high resistance to antimicrobial agents, in recent years biofilms have also been studied in the industrial sector, mainly because they are a major cause of contamination outbreaks in facilities and products. The aim of this study was to investigate whether different materials commonly found in the metalworking industries have different biofilm formation characteristics when in contact with contaminated cutting fluid as well as to establish an optimal concentration of a triazine-based antimicrobial agent to protect the oil/water emulsion and also to delay or interrupt the development of biofilms. Biofilms grown on the surface of carbon steel, stainless steel, aluminum, polyvinyl chloride, and glass were analyzed in terms of cell growth and susceptibility to the tested biocide. The results showed that the type of material used had little influence on cell adhesion or on the microbicide concentration required to control and eradicate microorganisms suspended in the emulsion and in the biofilms.