bluuebunny/crossref_metadata_2025_split huggingface dataset:
Analyse du travail des jurys en validation des acquis : l’usage du référentiel
Authors: Prot Bernard 
Published: May 2011

Cet article porte sur une analyse du travail menée avec des membres d’un jury de validation des acquis professionnels dans une perspective de clinique de l’activité. Après avoir brièvement présenté les méthodes d’autoconfrontation croisée, on analyse les commentaires de deux membres de jury sur les images de leur activité filmée pendant une session. En mobilisant la théorie instrumentale de Vygotski et sa reprise récente par Clot et par Rabardel, on montre que le référentiel de diplôme remplit plusieurs fonctions dans cette situation. L’une de ces fonctions retient particulièrement l’attention, étudiée à partir d’un second exemple : la mise en rapport des concepts quotidiens de la candidate avec un concept du référentiel, sous la forme d’un « concept potentiel ».
L’évaluation collective : l’exemple d’un jury de validation des acquis
Authors: Werthe Christiane 
Published: May 2011

La loi instaure un nouveau cadre d’évaluation des connaissances construites par les salariés dans leur expérience professionnelle : la validation des acquis. Cet article porte sur l’activité des membres de jury de validation des acquis, à partir des méthodes d’analyse du travail en Clinique de l’Activité. On montre, à partir d’un exemple, comment plusieurs points de vue disciplinaires se croisent sur un même élément du dossier dans lequel le candidat décrit ses activités. En analysant leur propre activité en autoconfrontation croisée, les membres de jury trouvent une occasion de développer leurs techniques d’évaluation et de prise de décision, individuelles et collectives. Cet article met également en lumière le fait que la recherche de critères d’évaluation concerne aussi les accompagnateurs qui doivent conseiller le candidat en amont du dispositif.
Relations entre feuilletons documentaires et choix de métier chez les adolescents
Authors: Beullens Kathleen , Bulck Jan Van den 
Published: May 2011

L’objectif de cette étude est d’explorer, chez les adolescents, la relation entre le fait de regarder des feuilletons documentaires et leurs projets de métier. Les résultats montrent que, parmi un échantillon de 369 adolescents en dernière année d’enseignement secondaire, le fait de regarder régulièrement un feuilleton documentaire portant sur les sages-femmes, les vétérinaires ou les parachutistes a été un prédicteur significatif d’une perception plus positive de cette profession. Des données écologiques sur les effectifs d’étudiants suggèrent que ceux-ci ont augmenté au cours des périodes qui ont suivi la diffusion d’un feuilleton documentaire à succès portant sur des professions particulières. La probabilité de s’inscrire comme étudiant dans un métier récemment montré dans un feuilleton documentaire a augmenté de 15 %. La discussion se centre sur les implications de ces résultats et met l’accent sur la nécessité de continuer des recherches dans cette sphère.
Que montre la télévision des professions et des professionnel(le)s ?
Authors: Bigeon Christine , Dosnon Odile , Guichard Jean 
Published: May 2011

Différents travaux en psychologie de l'orientation ont souligné le rôle que pouvaient jouer les personnages ou les personnes montrés à la télévision dans la formation des intentions d'avenir des adolescents. Par ailleurs, les spécialistes de l'étude des médias ont étudié comment la télévision pouvait infléchir certaines conduites ou représentations, voire certains styles de vie des téléspectateurs. Après avoir passé en revue ces travaux, l'article se focalise sur les professionnel(le)s donné(e)s à voir par la télévision au moyen d'une analyse systématique de tous les programmes diffusés en « prime time » sur les chaînes hertziennes françaises pendant une semaine. Si l'échantillon des professionnels représentés est sans rapport avec les réalités sociologiques du travail aujourd'hui, les activités professionnelles montrées – aussi bien dans les fictions que dans les documentaires – sont généralement réalistes. Elles occultent néanmoins certaines tâches importantes et épousent sans réserve les stéréotypes de genre relatifs aux professions. Les émissions destinées aux jeunes enfants apparaissent particulièrement caricaturales tant elles vont dans le sens d'un renforcement massif de ces rôles sociaux de sexe.
Coproduire des programmes TV aidant à réfléchir sur l’avenir professionnel ?
Authors: Vergnas Olivier Las 
Published: May 2011

Avertissement de l’auteur : le texte qui suit reprend celui d’une intervention prononcée à la journée Inetop-Université de Paris III du 14 mars 2008, consacrée à « Médias, travail, orientation » : une contribution à la réflexion fondée sur l’expérience de coproduction télévisuelle de la Cité des métiers. Il s’agit ici de décrire un cheminement et une pratique clinique suivis des interrogations et hypothèses qui en découlent aujourd’hui.De sa création en 1993 jusqu’à 2002, la Cité des métiers (CDM) s’est impliquée dans des coproductions TV. Produite en 1999 et 2000 avec l’aide du FSE, l’émission « Le temps des souris » a ainsi touché 36 millions de téléspectateurs. Mais, ensuite, les grilles de TV hertzienne de la période 2003-2007 proposant moins de cases consacrées régulièrement à ces thématiques, les opportunités de coproduction se sont raréfiées. Pour la CDM, cette période ne s’est soldée que par deux très petites séries de courts portraits dans le cadre de projets FSE. Refusant d’accepter que la TV hertzienne puisse n’être plus qu’un divertissement, dans le cadre duquel le fait de présenter une vision distordue de la société et de ses métiers et emplois importe peu, la CDM relance aujourd’hui la production d’une série documentaire destinée à France 3 et consacrée à la relation innovations territoires et emplois.
FIZZ2/RELM-β Induction and Role in Pulmonary Fibrosis
Authors: Liu Tianju , Baek Hyun Ah , Yu Hongfeng , Lee Ho Jin , Park Byung-Hyun , Ullenbruch Matthew , Liu Jianhua , Nakashima Taku , Choi Yoon Young , Wu Gary D. , Chung Myoung Ja , Phan Sem H. 
Published: May 2011

Abstract
Found in inflammatory zone (FIZZ) 2, also known as resistin-like molecule (RELM)-β, belongs to a novel cysteine-rich secreted protein family named FIZZ/RELM. Its function is unclear, but a closely related family member, FIZZ1, has profibrotic activities. The human ortholog of rodent FIZZ1 has not been identified, but human FIZZ2 has significant sequence homology to both rodent FIZZ2 (59%) and FIZZ1 (50%). Given the greater homology to rodent FIZZ2, analyzing the role of FIZZ2 in a rodent model of bleomycin-induced pulmonary fibrosis would be of greater potential relevance to human fibrotic lung disease. The results showed that FIZZ2 was highly induced in lungs of rodents with bleomycin-induced pulmonary fibrosis and of human patients with idiopathic pulmonary fibrosis. FIZZ2 expression was induced in rodent and human lung epithelial cells by Th2 cytokines, which was mediated via STAT6 signaling. The FIZZ2 induction in murine lungs was found to be essential for pulmonary fibrosis, as FIZZ2 deficiency significantly suppressed pulmonary fibrosis and associated enhanced extracellular matrix and cytokine gene expression. In vitro analysis indicated that FIZZ2 could stimulate type I collagen and α-smooth muscle actin expression in lung fibroblasts. Furthermore, FIZZ2 was shown to have chemoattractant activity for bone marrow (BM) cells, especially BM-derived CD11c+ dendritic cells. Notably, lung recruitment of BM-derived cells was impaired in FIZZ2 knockout mice. These findings suggest that FIZZ2 is a Th2-associated multifunctional mediator with potentially important roles in the pathogenesis of fibrotic lung diseases.
β2-Glycoprotein I and Protection from Anti-SSA/Ro60–Associated Cardiac Manifestations of Neonatal Lupus
Authors: Reed Joanne H. , Clancy Robert M. , Purcell Anthony W. , Kim Mimi Y. , Gordon Tom P. , Buyon Jill P. 
Published: May 2011

Abstract
One mechanism to molecularly explain the strong association of maternal anti-Ro60 Abs with cardiac disease in neonatal lupus (NL) is that these Abs initiate injury by binding to apoptotic cardiomyocytes in the fetal heart. Previous studies have demonstrated that β2-glycoprotein I (β2GPI) interacts with Ro60 on the surface of apoptotic Jurkat cells and prevents binding of anti-Ro60 IgG. Accordingly, the current study was initiated to test two complementary hypotheses, as follows: 1) competition between β2GPI and maternal anti-Ro60 Abs for binding apoptotic induced surface-translocated Ro60 occurs on human fetal cardiomyocytes; and 2) circulating levels of β2GPI influence injury in anti-Ro60–exposed fetuses. Initial flow cytometry experiments conducted on apoptotic human fetal cardiomyocytes demonstrated dose-dependent binding of β2GPI. In competitive inhibition experiments, β2GPI prevented opsonization of apoptotic cardiomyocytes by maternal anti-Ro60 IgG. ELISA was used to quantify β2GPI in umbilical cord blood from 97 neonates exposed to anti-Ro60 Abs, 53 with cardiac NL and 44 with no cardiac disease. β2GPI levels were significantly lower in neonates with cardiac NL. Plasmin-mediated cleavage of β2GPI prevented binding to Ro60 and promoted the formation of pathogenic anti-Ro60 IgG-apoptotic cardiomyocyte complexes. In aggregate these data suggest that intact β2GPI in the fetal circulation may be a novel cardioprotective factor in anti-Ro60–exposed pregnancies.
TLR2 Mediates the Innate Response of Retinal Muller Glia to Staphylococcus aureus
Authors: Shamsuddin Nazeem , Kumar Ashok 
Published: May 2011

Abstract
Muller cells, the principal glia of the retina, play several key roles in normal and various retinal diseases. To date, their direct involvement in retinal innate defense against bacterial pathogens has not been investigated. In this article, we show that Muller cells express TLR2, a key sensor implicated in recognizing Gram-positive bacteria. We found that intravitreal injection of TLR2 agonist Pam3Cys and Staphylococcus aureus activated Muller glia in C57BL/6 mouse retina. Similarly, Pam3Cys or S. aureus elicited the expression of TLR2 and activated the NF-κB and p38 MAPK signaling cascade. Concomitant with the activation of signaling pathways, transcriptional expression and secretion of various proinflammatory cytokines (IL-6, TNF-α, and IL-1β), chemokines (IL-8), and antimicrobial peptide (LL-37) were also induced in Muller glia. Importantly, the culture media derived from TLR2-activated Muller glia exhibited robust bactericidal activity against S. aureus. Furthermore, use of neutralizing Ab, small interfering RNA, and pharmacological inhibitors revealed that Muller glial innate response to S. aureus is mediated via the TLR2–NF-κB axis. Collectively, this study for the first time, to our knowledge, establishes that the retinal Muller glia senses pathogens via TLR2 and contributes directly to retinal innate defense via production of inflammatory mediators and antimicrobial peptides.
Human Lung Hydrolases Delineate Mycobacterium tuberculosis–Macrophage Interactions and the Capacity To Control Infection
Authors: Arcos Jesús , Sasindran Smitha J. , Fujiwara Nagatoshi , Turner Joanne , Schlesinger Larry S. , Torrelles Jordi B. 
Published: May 2011

Abstract
Pulmonary surfactant contains homeostatic and antimicrobial hydrolases. When Mycobacterium tuberculosis is initially deposited in the terminal bronchioles and alveoli, as well as following release from lysed macrophages, bacilli are in intimate contact with these lung surfactant hydrolases. We identified and measured several hydrolases in human alveolar lining fluid and lung tissue that, at their physiological concentrations, dramatically modified the M. tuberculosis cell envelope. Independent of their action time (15 min to 12 h), the effects of the hydrolases on the M. tuberculosis cell envelope resulted in a significant decrease (60–80%) in M. tuberculosis association with, and intracellular growth of the bacteria within, human macrophages. The cell envelope-modifying effects of the hydrolases also led to altered M. tuberculosis intracellular trafficking and induced a protective proinflammatory response to infection. These findings add a new concept to our understanding of M. tuberculosis–macrophage interactions (i.e., the impact of lung surfactant hydrolases on M. tuberculosis infection).
Amorphous and Crystalline GeTe Nanocrystals
Authors: Arachchige Indika U. , Soriano Ronald , Malliakas Christos D. , Ivanov Sergei A. , Kanatzidis Mercouri G. 
Published: May 2011

AbstractA facile method for the synthesis of crystalline and amorphous GeTe nanoparticles (NPs) using bis((trimethylsilyl)amido)germanium(II), Ge[N(SiMe3)2]2, and elemental tellurium dispersed in tri‐n‐octylphosphine (TOP) is reported. As synthesized, crystalline particles exhibit narrow dispersity at smaller sizes and tend to grow into anisotropic shapes with increasing reaction time (growth). Furthermore, crystalline GeTe NPs possess rhombohedral symmetry with absorption band energies in near IR region (0.76–0.86 eV). Amorphous GeTe particles prepared at low temperatures are nearly spherical in morphology and display amorphous‐to‐crystalline phase transition at 209–237 °C depending on their primary particle size. Detailed investigation of the local structure of the amorphous GeTe using pair distribution function (PDF) method reveals that it is closely related to that of the pressure‐ and temperature‐stabilized orthorhombic GeTe.
Electrospun poly(D,L)‐lactide nonwoven mats for biomedical application: Surface area shrinkage and surface entrapment
Authors: Xie Zhiwei , Buschle‐Diller Gisela , DeInnocentes Patricia , Bird R. Curtis 
Published: May 2011

AbstractNanofibrous poly(D,L)‐lactide mats prepared by electrospinning are useful for numerous biomedical applications. However, it was observed that these mats tend to shrink under physiological conditions. In this research, a physical entrapment method to modify the polymer surface with poly(ethylene glycol) was developed to ensure dimensional stability and to increase the hydrophilicity of the surface of the mats. Nanofiber morphology was characterized by scanning electron microscopy. Surface element analysis was performed by high resolution X‐ray photoelectron spectroscopy. Water contact angles were determined to identify surface properties before and after surface entrapment. Canine fibroblasts were prepared and seeded onto the poly(D,L)‐lactide mats, followed by cell morphology study by SEM and cell viability tests by MTT assay, which confirmed the improvement of biocompatibility by surface modification. Taking the results into account, hydrophilic and area‐stable nanofibrous nonwoven mats were successfully produced, with potential applications as in vivo biomedical material. © 2011 Wiley Periodicals, Inc. J Appl Polym Sci, 2011
Dielectric dispersion and AC conductivity of acrylonitrile butadiene rubber‐poly(vinyl chloride)/graphite composite
Authors: Mansour S. A. , Al‐ghoury M. E. , Shalaan E. , El Eraki M. H. I. , Abdel‐Bary E. M. 
Published: May 2011

AbstractDielectric properties and ac electrical conductivity of Acrylonitrile Butadiene Rubber‐poly(vinyl chloride)/Graphite Composite were studied at different frequencies (102−106 Hz) in the temperature range (298–423 K). The results show that the dielectric constant (ε′), dielectric loss (ε″), ac electrical conductivity (σac) and, the electric modulus are strongly dependent on the frequency and temperature. The dielectric constant ε′ increases with temperature and decreases with frequency, whereas the dielectric loss ε″ displays a broad maximum peak whose position shifts with temperature to a higher frequency region. Cole–Cole diagrams have been used to investigate the frequency dependence of the complex impedance at different temperature and graphite loading. Interfacial or Maxwell‐Wagner‐Sillars relaxation process was revealed in the frequency range and temperature interval of the measurements, which was found to follow the Havriliak–Negami approach for the distribution of relaxation times. At constant temperature, the frequency dependence of ac conductivity was found to fit with the established equation σac(ω) = Aωs quite well. The values of S for the investigated samples lie between 0.88 and 0.11. The conduction mechanism of ac conduction was discussed by comparing the behavior of the frequency exponent S(T) with different theoretical models. It was found that the correlated barrier hopping (C.B.H.) is the dominant conduction mechanism. © 2011 Wiley Periodicals, Inc. J Appl Polym Sci, 2011
Preparation and characterization of bipolar membranes modified using photocatalyst nano‐TiO2 and nano‐ZnO
Authors: Chen Riyao , Hu Yanyu , Chen Zhen , Chen Xiao , Zheng Xi 
Published: May 2011

AbstractThe nano‐ZnO and nano‐TiO2 were added into chitosan (CS) anion layer to prepare polyvinyl alcohol (PVA) ‐ sodium alginate (SA)/ TiO2‐ZnO‐CS (here, PVA:polyvinyl alcohol; SA:sodium alginate) bipolar membrane (BPM), which was characterized using scanning electron microscopy, atomic force microscopy (AFM), thermogravimetric analysis (TG), electric universal testing machine, contact angle measurer, and so on. Experimental results showed that nano‐TiO2‐ZnO exhibited better photocatalytic property for water splitting at the interlayer of BPM than nano‐TiO2 or nano‐ZnO. The membrane impedance and voltage drop (IR drop) of the BPM were obviously decreased under the irradiation of high‐pressure mercury lamps. At a current density of 60 mA/cm2, the cell voltage of PVA‐SA/TiO2‐ZnO‐CS BPM‐equipped cell decreased by 1.0 V. And the cell voltages of PVA‐SA/TiO2‐CS BPM‐equipped cell and PVA‐SA/ZnO‐CS BPM‐equipped cell were only reduced by 0.7 and 0.6 V, respectively. Furthermore, the hydrophilicity, thermal stability, and mechanical properties of the modified BPM were increased. © 2011 Wiley Periodicals, Inc. J Appl Polym Sci, 2011
Efficient synthesis of zwitterionic sulfobetaine group functional polyurethanes via “click” reaction
Authors: Huang Jingjing , Xu Weilin 
Published: May 2011

AbstractA novel polyurethane material containing zwitterionic sulfobetaine groups has been synthesized using the copper‐catalyzed 1,3‐dipolar cycloaddition (azide‐alkyne click chemistry). A standard two‐step polyaddition method was used to produce the well‐defined polyurethane based on polycarbonatediol (PCDL) with alkyne groups. These polyurethanes containing alkyne units were then efficiently clicked using 3‐((2‐azidoethyl)dimethylammonio)propane‐1‐sulfonate (DMPS‐N3). The novel PU material was characterized by 1H NMR, Fourier transform infrared (FTIR) spectrometer, gel permeation chromatography (GPC), elemental analysis, thermogravimetric analysis (TGA), differential scanning calorimetry (DSC), and dynamic mechanical analysis (DMA). This facile “click” reaction provides a useful tool for the development of novel functional polyurethanes for biomedical applications. © 2011 Wiley Periodicals, Inc. J Appl Polym Sci, 2011
Fabrication of self‐cleaning poly(vinylidene fluoride) membrane with micro/nanoscaled two‐tier roughness
Authors: Zheng Zhenrong , Gu Zhenya , Huo Ruiting , Luo Zhishan 
Published: May 2011

AbstractBased on the “lotus effect” principle, smooth microreliefs of polyvinylidene fluoride (PVDF) membrane were prepared via thermally induced phase separation process. Hydroxyl groups were introduced into PVDF membrane by pretreatment with KOH/alcohol solution. Subsequently, these hydroxyl groups grafted with (CH3)2SiCl2/CH3SiCl3 to form nano‐clusters, which were decorated on the microreliefs of PVDF membrane. Scanning Electronic Microscopy (SEM) and Atomic Force Microscope (AFM) analysis showed the micro‐ and nano‐scale structures, similar to lotus leaf, were successfully fabricated on the PVDF membrane surface. The water contact angle and sliding angle on the fabricated lotus‐leaf‐like PVDF membrane surface were 154 and 4°, respectively. Self‐cleaning test indicated that the lotus‐leaf‐like surface of PVDF membrane has excellent superhydrophobic and self‐cleaning properties. © 2011 Wiley Periodicals, Inc. J Appl Polym Sci, 2011
Delay‐dependent stability for Markovian genetic regulatory networks with time‐varying delays
Authors: Zhang Baoyong , Xu Shengyuan , Chu Yuming , Zong Guangdeng 
Published: May 2011

AbstractThis paper is concerned with the problem of stochastic stability analysis for a class of genetic regulatory networks with Markovian jump parameters and time‐varying delays. A delay‐dependent stability criterion is derived by using a novel mode‐dependent Lyapunov functional. The derived stability criterion is expressed in terms of linear matrix inequalities and is less conservative than the existing ones in the literature. A numerical example is provided to demonstrate the effectiveness of the proposed stability criterion.Copyright © 2011 John Wiley and Sons Asia Pte Ltd and Chinese Automatic Control Society
Preclinical Evaluation of Raman Nanoparticle Biodistribution for their Potential Use in Clinical Endoscopy Imaging
Authors: Zavaleta Cristina L. , Hartman Keith B. , Miao Zheng , James Michelle L. , Kempen Paul , Thakor Avnesh S. , Nielsen Carsten H. , Sinclair Robert , Cheng Zhen , Gambhir Sanjiv S. 
Published: May 2011

AbstractRaman imaging offers unsurpassed sensitivity and multiplexing capabilities. However, its limited depth of light penetration makes direct clinical translation challenging. Therefore, a more suitable way to harness its attributes in a clinical setting would be to couple Raman spectroscopy with endoscopy. The use of an accessory Raman endoscope in conjunction with topically administered tumor‐targeting Raman nanoparticles during a routine colonoscopy could offer a new way to sensitively detect dysplastic lesions while circumventing Raman's limited depth of penetration and avoiding systemic toxicity. In this study, the natural biodistribution of gold surface‐enhanced Raman scattering (SERS) nanoparticles is evaluated by radiolabeling them with 64Cu and imaging their localization over time using micropositron emission tomography (PET). Mice are injected either intravenously (IV) or intrarectally (IR) with approximately 100 microcuries (μCi) (3.7 megabecquerel (MBq)) of 64Cu‐SERS nanoparticles and imaged with microPET at various time points post injection. Quantitative biodistribution data are obtained as % injected dose per gram (%ID g−1) from each organ, and the results correlate well with the corresponding microPET images, revealing that IV‐injected mice have significantly higher uptake (p < 0.05) in the liver (5 h = 8.96% ID g−1; 24 h = 8.27% ID g−1) than IR‐injected mice (5 h = 0.09% ID g−1; 24 h = 0.08% ID g−1). IR‐injected mice show localized uptake in the large intestine (5 h = 10.37% ID g−1; 24 h = 0.42% ID g−1) with minimal uptake in other organs. Raman imaging of excised tissues correlate well with biodistribution data. These results suggest that the topical application of SERS nanoparticles in the mouse colon appears to minimize their systemic distribution, thus avoiding potential toxicity and supporting the clinical translation of Raman spectroscopy as an endoscopic imaging tool.