bluuebunny/crossref_metadata_2025_split huggingface dataset:
Bottom-up butterfly model with thorax-pitch control and wing-pitch flexibility
Authors: Suzuki Kosuke , Iguchi Daichi , Ishizaki Kou , Yoshino Masato 
Published: June 2024

Abstract
The diversity in butterfly morphology has attracted many people around the world since ancient times. Despite morphological diversity, the wing and body kinematics of butterflies have several common features. In the present study, we constructed a bottom-up butterfly model, whose morphology and kinematics are simplified while preserving the important features of butterflies. The present bottom-up butterfly model is composed of two trapezoidal wings and a rod-shaped body with a thorax and abdomen. Its wings are flapped downward in the downstroke and backward in the upstroke by changing the geometric angle of attack (AOA). The geometric AOA is determined by the thorax-pitch and wing-pitch angles. The thorax-pitch angle is actively controlled by abdominal undulation, and the wing-pitch angle is passively determined because of a rotary spring representing the basalar and subalar muscles connecting the wings and thorax. We investigated the effectiveness of abdominal undulation for thorax-pitch control and how wing-pitch flexibility affects aerodynamic-force generation and thorax-pitch control, through numerical simulations using the immersed boundary–lattice Boltzmann method. As a result, the thorax-pitch angle perfectly follows the desired angle through abdominal undulation. In addition, there is an optimal wing-pitch flexibility that maximizes the flying speed in both the forward and upward directions, but the effect of wing-pitch flexibility on thorax-pitch control is not significant. Finally, we compared the flight behavior of the present bottom-up butterfly model with that of an actual butterfly. It was found that the present model does not reproduce reasonable body kinematics but can provide reasonable aerodynamics in butterfly flights.
Unraveling boreal forest composition and drivers across scales in eastern Siberia
Authors: Enguehard Léa , Kruse Stefan , Heim Birgit , Nitze Ingmar , Falco Nicola , Demir Begum , Herzschuh Ulrike 
Published: June 2024

Abstract
The Siberian boreal forest is the largest continuous forest region on Earth and plays a crucial role in regulating global climate. However, the distribution and environmental processes behind this ecosystem are still not well understood. Here, we first develop Sentinel-2-based classified maps to show forest-type distribution in five regions along a southwest-northeast transect in eastern Siberia. Then, we constrain the environmental factors of the forest-type distribution based on a multivariate analysis of bioclimatic variables, topography, and ground-surface temperatur at the local and regional scales. Furthermore, we identify potential versus realized forest-type niches and their applicability to other sites. Our results show that mean annual temperature and mean summer and winter temperatures are the most influential predictors of forest-type distribution. Furthermore, we show that topography, specifically slope, provides an additional but smaller impact at the local scale. We find that the filling of climatic environmental niches by forest types decreases with geographic distance, but that the filling of topographic niches varies from one site to another. Our findings suggest that boreal forests in eastern Siberia are driven by current climate and topographical factors, but that there remains a portion of the variability that cannot be fully accounted for by these factors alone. While we hypothesize that this unexplained variance may be linked to legacies of the Late Glacial, further evidence is needed to substantiate this claim. Such results are crucial to understanding and predicting the response of boreal forests to ongoing climate change and rising temperatures.
Influence of Marine Heatwaves on Upwelling Parameter in Indonesian Fisheries Management Area (IFMA) 713 Waters
Authors: Kamila I H , Ningsih N S , Beliyana E 
Published: June 2024

Abstract
An upwelling process linked to water productivity is likely to be affected by marine heatwaves (MHWs). The events of MHWs are distinguished by warmer sea surface temperature (SST), leading to increased stratification, causing vertical mixing limits and suppressing the upwelling process. In the Indonesian Fisheries Management Area (IFMA) 713 waters, which have enormous potential for fishery resources, five upwelling areas were identified during the southeast monsoon months (May–October) based on the Ekman pumping velocity (EPV) assessment, namely locations A (western part of West Sulawesi), B (southern Makassar), C (eastern part of Bone Bay), D (southern Banjarmasin), and E (southern Makassar Strait). Thus, this study aimed to investigate the influence of MHWs on upwelling parameter (chlorophyll-a concentration) in IFMA 713, particularly in 1998 and 2016, where prominent MHWs occurred and coincided with upwelling sessions. To accomplish this, EPV anomalies and chlorophyll-a concentrations for each MHWs event during May–October 1998 and 2016 were calculated. The analysis revealed that MHWs events co-occuring with negative (upwelling velocity is weaker than the climatological mean) and positive (upwelling velocity is stronger than the climatological average) EPV anomalies were associated with decreased chlorophyll-a concentrations.
Distribution of Potassium and Calcium Ions in Padelegan Waters and Their Correlation to Water Quality
Authors: Septian H. , Kartika A. G. D. , Nuzula N. I. , Pratiwi W. S. W. 
Published: June 2024

Abstract
The main ion content in seawater can provide information about the quality of seawater. Two of the important ions contained in seawater are potassium and calcium. Minerals such as potassium and calcium are inorganic components, components of body tissue and components of body liquids that work in conjunction with proteins, hormones, vitamins and other transport materials. The strategy utilized to decide the substance of potassium and calcium in tests utilizing AAS (Atomic Absorption Spectrophotometry). This think about points to decide the substance of potassium and calcium in Padelegan waters and their dispersion, to get a relationship between the two particles and water quality. There are six points used as seawater sampling sites in Padelegan waters. Therefore, so that the results obtained potassium concentrations ranged from 102.83 to 267.49 mg/L, and those for calcium from 205.61 to 492.49 mg/L. The results of correlation research between potassium and calcium concentrations and sea water quality in Padelegan waters show a weak negative correlation in Turbidity, pH, Salinity, Total Dissolved Solids (TDS), Dissolved Oxygen (DO), and Specific Gravity (SG), and a weak positive correlation for Temperature parameter. So that the levels of potassium and calcium contained in Padelegan waters at the six stations are in accordance with sea water quality standards.
Locals and Tourists Participation on Coral Reef Rehabilitation in Seribu Islands, Indonesia
Authors: Rohman M I N , Rohmat Fauzan I W , Rohmat Faizal I W , Rohmat D , Murtianto H , Eridiana W 
Published: June 2024

Abstract
Despite coral reefs being one of the main attractions for marine tourism activities, these activities are also the main factor causing coral damage. To preserve and overcome the damage to coral reefs, rehabilitation activities involving the community and tourists should be attempted. This research studies the locals’ and tourists’ participation and involvement in coral reef rehabilitation activities on Pramuka Island and Pari Island. The results show that the level of local participation and involvement on Pramuka Island is generally moderate, while on Pari Island, the level is generally high. The locals on Pramuka Island predominantly participate in the form of ideas (46,91%) and are involved in implementing rehabilitation activities (59,64%). On Pari Island, participation is more diverse; it comes in the form of labor (69,47%), time (57,72%), and skills (59,47%), and is more involved in implementing (68,95%) and benefiting from rehabilitation (64,74%). The productive age group dominates the age group active in rehabilitation activities on Pramuka Island, while on Pari Island, it is dominated by young people. In general, tourist participation and involvement in both research locations are still minimal. Thus, efforts to develop rehabilitation activities on Pramuka Island must focus more on young people by emphasizing participation in various aspects. Meanwhile, on Pramuka Island, rehabilitation activities must involve more productive age communities and integrate them with existing communities. Tourist participation and involvement can be integrated with existing tourism activities for these two locations.
Potential of Organic Carbon Pool in the Ocean: Approaches for Naturally and Artificially Capturing and Retaining Carbon
Authors: Wahyudi A J 
Published: June 2024

Abstract
The organic carbon stored in the seas and coastal ecosystems is referred to as “blue carbon.” Studies on blue carbon have focused a lot of emphasis on ocean ecosystems such seagrass beds, mangroves, saltmarshes, and algae beds. However, these vegetated ecosystems are not the exclusive repositories of atmospheric carbon, and alternative methods of capturing and retaining carbon naturally (by utilizing the inherent capacity of the ocean) and artificially (through the implementation of engineered approaches) are thus being investigated. This study provides an overview of these approaches and assesses the potential for storing organic carbon beyond vegetated ecosystems. The study used a systematic evaluation of the literature in order to determine the trend in blue carbon research, particularly with regard to carbon storage beyond vegetated environments. Besides the carbon sequestration by the marine vegetation, the present study proposes the feasibility of capturing aquatic carbon through a biological pump process that has the potential to store carbon at the ocean floor. Furthermore, we summarize the potential impact of artificial processes on carbon dioxide removal. This study suggests an expanded definition of “blue carbon” that incorporates the concepts of “organic carbon,” “carbon dioxide removal,” and “carbon capture and storage by oceans and coastal ecosystems.”
Tsunami model of the 2021 Flores earthquake and its impact on Labuan Bajo, East Nusa Tenggara
Authors: Sudjono E H , Novico F , Karima S , Handiani D N , Suhermat M , Rusdiansyah A , Shomim A F , Qonita Z , Tohari A , Handoyo K M , Susilohadi  , Syahbana A J , Setyonegoro W 
Published: June 2024

Abstract
The Flores earthquake on December 14, 2021, was recorded to cause a weak tsunami in East Nusa Tenggara. The epicenter was in the Flores Sea within 10 km of the hypocenter that triggered M 7.3 and impacted some coastline regions of East Nusa Tenggara, including Labuan Bajo. This study aimed to hindcast this phenomenon and mitigate the coastline region by applying the forecasting scenarios related to the amplification of the earthquake magnitudes and type of the sub-bottom displacements. The TUNAMI Software has been selected to illustrate tsunami wave propagation and inundation. The elevation data for the inputting model used BATNAS-DEMNAS National, while the rest of the parameters were applied using the two scenarios and the best guess. Based on the model results, it can be concluded that the source characteristics and the magnitudes played an essential role in inundating the coastal region in Labuan Bajo, West Manggarai Regency, East Nusa Tenggara.
A 3D-printed tumor-on-chip: user-friendly platform for the culture of breast cancer spheroids and the evaluation of anti-cancer drugs
Authors: Gallegos-Martínez Salvador , Choy-Buentello David , Pérez-Álvarez Kristen Aideé , Lara-Mayorga Itzel Montserrat , Aceves-Colin Alberto Emmanuel , Zhang Yu Shrike , Trujillo-de Santiago Grissel , Álvarez Mario Moisés 
Published: June 2024

Abstract
Tumor-on-chips (ToCs) are useful platforms for studying the physiology of tumors and evaluating the efficacy and toxicity of anti-cancer drugs. However, the design and fabrication of a ToC system is not a trivial venture. We introduce a user-friendly, flexible, 3D-printed microfluidic device that can be used to culture cancer cells or cancer-derived spheroids embedded in hydrogels under well-controlled environments. The system consists of two lateral flow compartments (left and right sides), each with two inlets and two outlets to deliver cell culture media as continuous liquid streams. The central compartment was designed to host a hydrogel in which cells and microtissues can be confined and cultured. We performed tracer experiments with colored inks and 40 kDa fluorescein isothiocyanate dextran to characterize the transport/mixing performances of the system. We also cultured homotypic (MCF7) and heterotypic (MCF7-BJ) spheroids embedded in gelatin methacryloyl hydrogels to illustrate the use of this microfluidic device in sustaining long-term micro-tissue culture experiments. We further demonstrated the use of this platform in anticancer drug testing by continuous perfusion of doxorubicin, a commonly used anti-cancer drug for breast cancer. In these experiments, we evaluated drug transport, viability, glucose consumption, cell death (apoptosis), and cytotoxicity. In summary, we introduce a robust and friendly ToC system capable of recapitulating relevant aspects of the tumor microenvironment for the study of cancer physiology, anti-cancer drug transport, efficacy, and safety. We anticipate that this flexible 3D-printed microfluidic device may facilitate cancer research and the development and screening of strategies for personalized medicine.
Multiple imputation for propensity score analysis with covariates missing at random: some clarity on “within” and “across” methods
Authors: Nguyen Trang Quynh , Stuart Elizabeth A 
Published: June 2024

Abstract
In epidemiology and the social sciences, propensity score methods are popular for estimating treatment effects using observational data, and multiple imputation is popular for handling covariate missingness. However, how to appropriately use multiple imputation for propensity score analysis is not completely clear. This paper aims to bring clarity on the consistency (or lack thereof) of methods that have been proposed, focusing on the “within” approach (where the effect is estimated separately in each imputed dataset and then the multiple estimates are combined) and the “across” approach (where typically propensity scores are averaged across imputed datasets before being used for effect estimation). We show that the within method is valid and can be used with any causal effect estimator that is consistent in the full-data setting. Existing across methods are inconsistent, but a different across method that averages the inverse probability weights across imputed datasets is consistent for propensity score weighting. We also comment on methods that rely on imputing a function of the missing covariate rather than the covariate itself, including imputation of the propensity score and of the probability weight. Based on consistency results and practical flexibility, we recommend generally using the standard within method. Throughout, we provide intuition to make the results meaningful to the broad audience of applied researchers.
Practice-enhancing publications about the medication-use process in 2021
Authors: Vest Tyler A , Gazda Nicholas P , O’Neil Daniel P , Eckel Stephen F 
Published: June 2024

Abstract

Purpose
This article identifies, prioritizes, and summarizes published literature on the medication-use process (MUP) from calendar year 2021 that can impact health-system pharmacy daily practice. The MUP is the foundational system that provides the framework for safe medication utilization within the healthcare environment. The MUP is defined in this article as having the following components: prescribing/transcribing, dispensing, administration, and monitoring, and monitoring/medication reconciliation. Articles evaluating at least one step of the MUP were assessed for their usefulness toward practice improvement.

Summary
A PubMed search was conducted in January 2022 for articles published in calendar year 2021 using targeted Medical Subject Headings (MeSH) keywords, and searches of the table of contents of selected pharmacy journals were conducted, providing a total of 7,178 articles. A thorough review identified 79 potentially practice-enhancing articles: 15 for prescribing/transcribing, 17 for dispensing, 4 for administration, 21 for monitoring, and 22 for monitoring/medication reconciliation. Ranking of the articles for importance by peers led to the selection of key articles from each category. The highest-ranked articles are briefly summarized, with a mention of their importance within health-system pharmacy. The other articles are listed for further review and evaluation.

Conclusion
It is important to routinely review the published literature and to incorporate significant findings into daily practice. This article assists in identifying and summarizing the most impactful publications. Health-system pharmacists have an active role in improving the MUP in their institution, and awareness of the significant published studies can assist in changing practice at the institutional level.
VII—The Straight-edge of Virtue: Aristotle on the Rational Significance of Beauty-in-Action
Authors: Lear Gabriel Richardson 
Published: June 2024

Abstract
Aristotle claims that the virtuous person acts for the sake of to kalon. To understand this idea, I examine the analogy he draws between craft and virtue. I argue that the kalon is a formal feature of well-ordered wholeness and that the virtuous person takes intellectual pleasure in perceiving (or remembering or imagining) the kalon-in-action, akin to pleasure in observing artworks or works of nature. However, the virtuous person’s pleasure in kalon action is primarily a pleasure of practical reason. In these ways, Aristotle’s concept of the kalon is and is not like the modern aesthetic concept of the beautiful.
Revolutionizing GPCR–ligand predictions: DeepGPCR with experimental validation for high-precision drug discovery
Authors: Zhang Haiping , Fan Hongjie , Wang Jixia , Hou Tao , Saravanan Konda Mani , Xia Wei , Kan Hei Wun , Li Junxin , Zhang John Z H , Liang Xinmiao , Chen Yang 
Published: June 2024

Abstract
G-protein coupled receptors (GPCRs), crucial in various diseases, are targeted of over 40% of approved drugs. However, the reliable acquisition of experimental GPCRs structures is hindered by their lipid-embedded conformations. Traditional protein–ligand interaction models falter in GPCR–drug interactions, caused by limited and low-quality structures. Generalized models, trained on soluble protein–ligand pairs, are also inadequate. To address these issues, we developed two models, DeepGPCR_BC for binary classification and DeepGPCR_RG for affinity prediction. These models use non-structural GPCR–ligand interaction data, leveraging graph convolutional networks and mol2vec techniques to represent binding pockets and ligands as graphs. This approach significantly speeds up predictions while preserving critical physical–chemical and spatial information. In independent tests, DeepGPCR_BC surpassed Autodock Vina and Schrödinger Dock with an area under the curve of 0.72, accuracy of 0.68 and true positive rate of 0.73, whereas DeepGPCR_RG demonstrated a Pearson correlation of 0.39 and root mean squared error of 1.34. We applied these models to screen drug candidates for GPR35 (Q9HC97), yielding promising results with three (F545-1970, K297-0698, S948-0241) out of eight candidates. Furthermore, we also successfully obtained six active inhibitors for GLP-1R. Our GPCR-specific models pave the way for efficient and accurate large-scale virtual screening, potentially revolutionizing drug discovery in the GPCR field.
Interferon-tau infusion into the ovine corpus luteum delays luteolysis
Authors: Guzeloglu Aydin , Bishop Jeanette V , Van Campen Hana , Plewes Michele R , Gonzalez-Berrios Carolina L , Kincade Jessica N , Davis John S , Hansen Thomas R 
Published: June 2024

Abstract
Conceptus-derived interferon-tau (IFNT) initiates maternal recognition of pregnancy in ewes by paracrine actions on the endometrium and endocrine action on the corpus luteum (CL). To examine the effect of IFNT on the CL without inducing IFN-stimulated genes (ISGs) in the endometrium, recombinant ovine IFNT (roIFNT) or bovine serum albumin was delivered directly into CLs via osmotic pumps at a rate of 10, 50, or 100 ng/h from days 9 to 12 of the estrous cycle. Endometrial and CL samples were collected on day 12. 50 ng/h of roIFNT induced ISG15 in the CL on day 12 without affecting endometrial ISG15 concentrations. In a second experiment, roIFNT (50 ng/h) was infused into the CL from days 10 to 17 of the estrous cycle and serum samples were collected daily. Serum progesterone concentrations were significantly higher from days 15 to 17 in roIFNT-infused ewes compared to controls. Levels of LHCGR, STAR, CYP11A1, HSL, OPA1, and protein kinase A mRNA and proteins were higher in the roIFNT-infused CLs compared to the controls. Levels of ISG15 and MX1 mRNA increased in the CLs of roIFNT-infused ewes but not in the endometrium. Endometrial ESR1 mRNA and protein concentrations were higher in the controls compared to roIFNT-infused ewes. In conclusion, intra-luteal delivery of roIFNT induced ISGs, stabilized steroidogenesis in the CL, and delayed luteolysis without inducing endometrial IFN-stimulated genes. Inhibition of ESR1 in the endometrium of roIFNT-infused ewes was observed suggesting that direct delivery of IFNT to the CL has an additional anti-luteolytic effect on the endometrium.
The transfer of male cuticular hydrocarbons provides a reliable cue of the risk and intensity of sperm competition in decorated crickets
Authors: House Clarissa M , Duffield Kristin , Rapkin James , Sakaluk Scott K , Hunt John 
Published: June 2024

Abstract
Theoretically, males should increase their ejaculate expenditure when the probability of sperm competition occurring (or risk) is high but decrease ejaculate expenditure as the number of competing ejaculates (or intensity) increases. Here we examine whether male decorated crickets (Gryllodes sigillatus) use cuticular hydrocarbons (CHCs) transferred to females by rival males at mating to assess the risk and intensity of sperm competition and adjust their ejaculate accordingly. Unmated females and those perfumed with CHCs extracted from one, three, or five males could be distinguished chemically, providing a reliable cue of the risk and intensity of sperm competition. In agreement with theory, males mating with these females increased sperm number with the risk of sperm competition and decreased sperm number with the intensity of sperm competition. Similarly, as the risk of sperm competition increased, males produced a larger and more attractive spermatophylax (an important non-sperm component of the ejaculate) but these traits did not vary with the intensity of sperm competition. Our results therefore demonstrate that both sperm and non-sperm components of the male ejaculate respond to the risk and intensity of sperm competition in different ways and that CHCs provide males with an important cue to strategically tailor their ejaculate.