bluuebunny/crossref_metadata_2025_split huggingface dataset:
Implant surface modifications and their impact on osseointegration and peri‐implant diseases through epigenetic changes: A scoping review
Authors: Kunrath Marcel F. , Garaicoa‐Pazmino Carlos , Giraldo‐Osorno Paula Milena , Haj Mustafa Aya , Dahlin Christer , Larsson Lena , Asa'ad Farah 
Published: May 2024

AbstractDental implant surfaces and their unique properties can interact with the surrounding oral tissues through epigenetic cues. The present scoping review provides current perspectives on surface modifications of dental implants, their impact on the osseointegration process, and the interaction between implant surface properties and epigenetics, also in peri‐implant diseases. Findings of this review demonstrate the impact of innovative surface treatments on the epigenetic mechanisms of cells, showing promising results in the early stages of osseointegration. Dental implant surfaces with properties of hydrophilicity, nanotexturization, multifunctional coatings, and incorporated drug‐release systems have demonstrated favorable outcomes for early bone adhesion, increased antibacterial features, and improved osseointegration. The interaction between modified surface morphologies, different chemical surface energies, and/or release of molecules within the oral tissues has been shown to influence epigenetic mechanisms of the surrounding tissues caused by a physical–chemical interaction. Epigenetic changes around dental implants in the state of health and disease are different. In conclusion, emerging approaches in surface modifications for dental implants functionalized with epigenetics have great potential with a significant impact on modulating bone healing during osseointegration.
Distribution analysis of rare earth elements in fine‐grained CAIs of the Allende meteorite using multiple‐spot femtosecond LA‐ICP‐MS
Authors: Masuda Yuki , Niki Sota , Hirata Takafumi , Yokoyama Tetsuya 
Published: May 2024

ABSTRACTCalcium–aluminum‐rich inclusions (CAIs) in chondrites are one of the oldest materials in the solar system. Presence of refractory minerals in CAIs suggests that they formed thorough a condensation process from nebular gas of solar composition. In particular, fine‐grained CAIs (FGs) have escaped melting after condensation, and thus, the elemental distribution of rare earth elements (REEs) in FG minerals provides key information for elucidating the condensation processes. Although the REE abundances of FG fragments have been investigated in previous studies, the distribution of REEs in individual FG constituent minerals remains poorly explored. Here, we demonstrate the utility of laser imaging of REE distribution in CAIs by analyzing five FGs found in the Allende CV3 chondrite using multiple‐spot femtosecond laser ablation (msfsLA)‐ICP‐MS. The msfsLA‐ICP‐MS imaging system allows for a rapid acquisition of a wider range of REE distributions than previously achieved by Secondary ion mass spectrometry‐based imaging techniques. Out of the five FGs examined in this study, three showed the homogeneous REE patterns, while the other two indicated variable REE patterns within each FG. These observations presumably reflect differences in the chemical processes experienced by the FGs, and indicate that multi‐step chemical processes were recorded in some of the FGs. The msfsLA‐ICP‐MS imaging technique can characterize the elemental distribution of individual FGs under the comparable spatial resolution with high‐analysis throughput, and thus, it is an effective new method for advancing the taxonomy of FGs, which will improve our understanding of the physicochemical conditions that prevailed in the early solar system.
Conflict fuels inflation but the tinder lies elsewhere: Eclectic structuralist thoughts in a developing economy context
Authors: Razmi Arslan 
Published: May 2024

AbstractDeveloping country inflation is in the headlines again. Mainstream macroeconomics typically ignores the role of conflict while non‐mainstream work tends to ignore macroeconomic constraints. This paper revisits the issue employing a dependent economy framework with eclectic characteristics. Specifically, I explore the mechanisms that propagate both real and monetary sources of inflation in the presence of real wage resistance and distributional conflict. The analysis shows that the inability to pay for subsidies with taxes or bond issuance in a stylized developing economy could create a situation where a relatively small shock leads to sustained and accelerating inflation and a wage‐price spiral, thanks to conflicting claims on income. Subsidies to protect consumers from external price shocks could, similarly, leave a country vulnerable to accelerating wage‐price spirals as the stabilizing relative price effects of a declining foreign asset position are dampened. Distributional conflict thus plays the role of sustainer rather than the primum mobile. Price controls could, in theory, better enable inflation management if these do not result in redistribution toward spenders. Such controls, however, create other trade‐offs for countries facing balance‐of‐payments fragility.
Older persons' experiences of frailty: A systematic review
Authors: Farrelly Alice , Daly Louise 
Published: May 2024

AbstractObjectivesThe objective of this study was to synthesise the evidence of older persons’ experiences of frailty.BackgroundThe world's population is ageing with those aged over 60 years expected to total 2 billion by 2050. Although not exclusive to ageing, there is a higher prevalence of frailty in older adults, with corresponding demand for related healthcare. While definitions of frailty are debated, there is emerging consensus that sole reliance on biomedical conceptualisations is inadequate to capture the complex needs of older persons living with frailty. In addition, the voices of older persons have largely been excluded from frailty discourses. There is a consequent need for an expanded approach.MethodsA meta‐synthesis was conducted of the literature on older persons' experiences of frailty. CINAHL, Medline, Embase and ASSIA databases were systematically searched up to January 2024. Reference lists of retrieved sources and grey literature were also searched. Studies were independently evaluated for inclusion by two reviewers using predetermined inclusion criteria. Included studies were quality appraised using a standardised tool, and extracted data were thematically analysed and synthesised.ResultsEight hundred and thirteen studies were identified as potentially relevant. Following title and abstract review, 52 studies were selected for full‐text review. Thirty‐four studies were subsequently excluded as they did not address the systematic review question, leaving 17 included in the final review. An additional two studies were identified via grey literature sources. Older persons' experiences of frailty were synthesised with reference to three themes: (i) living with frailty: a multidimensional experience; (ii) living with frailty: acceptability and associations; and (iii) living with frailty: resisting and adapting and losing control.ConclusionsOlder persons' experiences of frailty revealed a resistance to the biomedical use of the term generally used in clinical practice. Instead, a more nuanced and multidimensional understanding of frailty was identified in the experiences of older persons.Implications for PracticeHealth and social care personnel should therefore consider an expanded approach in practice that incorporates the perspective of older people who strive to maintain independence and control when living with frailty. Doing so may enhance shared understanding and person‐centred care planning between older persons and professionals.
Atypical familial hemophagocytic lymphohistiocytosis type 3 in children: A report of cases and literature review
Authors: Zhao Qin , Zhao Qian , Tang Xuemei , An Yunfei , Zhang Zhiyong , Tomomasa Dan , Hijikata Atsushi , Yang Xi , Kanegane Hirokazu , Zhao Xiaodong 
Published: May 2024

AbstractBackgroundFamilial hemophagocytic lymphohistiocytosis type 3 (FHL3) is caused by UNC13D variants. The clinical manifestations of FHL3 are highly diverse and complex. Some patients exhibit atypical or incomplete phenotypes, making accurate diagnosis difficult. Our study aimed to broaden the understanding of the atypical FHL3 clinical spectrum.MethodsIn our study, we analyzed in detail the clinical features of four Chinese patients with UNC13D variants. Additionally, we conducted a comprehensive review of the existing literature on previously reported atypical manifestations and summarized the findings.ResultsTwo of our patients presented with muscle involvement, while the other two had hematological involvement; none of them met the diagnostic criteria for hemophagocytic lymphohistiocytosis (HLH). However, protein expression and functional analysis ultimately confirmed diagnostic criteria for FHL3 in all patients. From the literature we reviewed, many atypical FHL3 patients had neurological involvement, especially isolated neurological manifestations. At the same time, arthritis and hypogammaglobulinemia were also prone to occur.ConclusionOur study highlights that the expression of the Munc13‐4 protein may not fully indicate the pathogenicity of UNC13D variants, whereas CD107a analysis could be more sensitive for disease diagnosis. These findings contribute to a broader understanding of the FHL3 clinical spectrum and may offer new insights into the underlying pathogenesis of UNC13D variants. It is crucial to prioritize the timely and accurate diagnosis of atypical patients, as they may often be overlooked among individuals with rheumatic or hematological diseases.
ZmABF4‐ZmVIL2/ZmFIP37 module enhances drought tolerance in maize seedlings
Authors: Zhang Dongling , Ma Shixiang , Liu Zhixue , Yang Yuwei , Yang Wenjing , Zeng Haixia , Su Huihui , Yang Yang , Zhang Wanjun , Zhang Jing , Ku Lixia , Ren Zhenzhen , Chen Yanhui 
Published: May 2024

AbstractDrought, as a primary environmental factor, imposes significant constraints on developmental processes and productivity of plants. PHDs were identified as stress‐responsive genes in a wide range of eukaryotes. However, the regulatory mechanisms governing PHD genes in maize under abiotic stress conditions are still largely unknown and require further investigation. Here, we identified a mutant, zmvil2, in the EMS mutant library with a C to T mutation in the exon of the Zm00001d053875 (VIN3‐like protein 2, ZmVIL2), resulting in premature termination of protein coding. ZmVIL2 belongs to PHD protein family. Compared to WT, zmvil2 mutant exhibited increased sensitivity to drought stress. Consistently, overexpression of ZmVIL2 enhances drought resistance in maize. Y2H, BiFC, and Co‐IP experiments revealed that ZmVIL2 directly interacts with ZmFIP37 (FKBP12‐interacting protein of 37). zmfip37 knockout mutants also exhibit decreased drought tolerance. Interestingly, we demonstrated that ZmABF4 directly binds to the ZmVIL2 promoter to enhance its activity in yeast one hybrid (Y1H), electrophoretic mobility shift assay (EMSA) and dual luciferase reporter assays. Therefore, we uncovered a novel model ZmABF4‐ZmVIL2/ZmFIP37 that promotes drought tolerance in maize. Overall, these findings have enriched the knowledge of the functions of PHD genes in maize and provides genetic resources for breeding stress‐tolerant maize varieties.
Nasal inhalation does not improve memory of visual repetitions
Authors: Thunell Evelina , Francis Gregory , Dal Bò Elisa , Schaefer Martin , Lundström Johan N. , Arshamian Artin 
Published: May 2024

AbstractSeveral studies suggest that breathing entrains neural oscillations and thereby improves visual detection and memory performance during nasal inhalation. However, the evidence for this association is mixed, with some studies finding no, minor, or opposite effects. Here, we tested whether nasal breathing phase influences memory of repeated images presented in a rapid serial visual presentation (RSVP) task. The RSVP task is ideal for studying the effects of respiratory‐entrained oscillations on visual memory because it engages critical aspects of sensory encoding that depend on oscillatory activity, such as fast processing of natural images, repetition detection, memory encoding, and retrieval. It also enables the presentation of a large number of stimuli during each phase of the breathing cycle. In two separate experiments (n = 72 and n = 142, respectively) where participants were explicitly asked to breathe through their nose, we found that nasal breathing phase at target presentation did not significantly affect memory performance. An exploratory analysis in the first experiment suggested a potential benefit for targets appearing approximately 1 s after inhalation. However, this finding was not replicated in the pre‐registered second experiment with a larger sample. Thus, in two large sample experiments, we found no measurable impact of breathing phase on memory performance in the RSVP task. These results suggest that the natural breathing cycle does not have a significant impact on memory for repeated images and raise doubts about the idea that visual memory is broadly affected by the breathing phase.
The Public Interest: Clarifying a Legal Concept
Authors: Boot Eric R. 
Published: May 2024

AbstractAppeals to the public interest in law are commonplace, but typically made without clarifying what the public interest is and how it can be determined. In law, this has led to ad hoc applications of the public interest and, consequently, to “judicial idiosyncrasy,” posing a threat to legal certainty. This paper aims to remedy these problems by providing much‐needed conceptual clarification. It proposes that something is in the public interest if it increases the opportunities of the members of the public to pursue and realize the (permissible) ends they all share qua equal members of the public.
The state of the question in early Heidegger studies
Authors: Blattner William 
Published: May 2024

AbstractThis article surveys the state of the literature in English‐language scholarship on Heidegger's early work (1919–29). The survey falls into roughly two halves. The first is devoted to scholarship on Heidegger's intellectual development during the 1920s, focusing on four themes: Heidegger's relationship to Husserl; Heidegger's early phenomenology of religious life; Heidegger's appropriation of Aristotle; and Heidegger's retrieval of Kant's First Critique. The second half focuses on work on the early Heidegger that has arisen out of the reception of his early thought into mainstream Anglophone philosophy. It examines Hubert Dreyfus's interpretation of Heidegger, the status of “das Man” and social normativity, Heidegger's concept of death, Heidegger's conception of authenticity, and truth (with a very brief overview of further topics).
Cross‐ownership, business dynamism, and wage inequality in general equilibrium
Authors: Beladi Hamid , Chao Chi‐Chur , Chin Kuo‐Hsuan 
Published: May 2024

AbstractThis study examines the distributive and welfare effects of cross‐ownership by firms in a general equilibrium economy on the product and factor markets. The cross‐ownership of equities, such as collusion, tends to be anticompetitive, thereby narrowing the wage gap between skilled and unskilled labor in the short term with the existing number of firms. In the capital market, reducing capital cost through cross‐ownership causes new firms to enter the market in the long term. This firm‐entry effect induced by cross‐ownership through an increase in the number of competitors generates a competitive force that exacerbates wage inequality and reduces welfare in the economy.
Hybrid cord blood banking in a private‐public‐partnership: Women's perspectives
Authors: Laue Jessica , Ambühl Johanna , Surbek Daniel 
Published: May 2024

AbstractBackgroundThe increasing demand for umbilical cord blood (UCB) used in stem cell transplantation led to the establishment of cord blood (CB) banks worldwide. These include public foreign donor banks and private family‐directed donor banks. Recently, our department has introduced a third banking model within a private‐public‐partnership. This hybrid banking allows for storage of family‐directed CB units, while also getting Human leukocyte antigen (HLA)‐typed and included in the national stem cell donor registry. So if the need arises, the HLA‐compatible CB unit can be released to an unrelated recipient as a foreign donor stem cell graft.ObjectivesThe aim of this study was to evaluate women's perspectives on the different CB banking options as well as retrospective satisfaction with their decisions.MethodsWe performed a prospective survey study in postpartum women, using a validated questionnaire.ResultsA total of 157 women were included in this survey study; 68% of them decided to have their UCB stored or donated. Among those women, 25% of them opted for hybrid storage, 72% of respondents stored UCB publicly, and 3% decided for private family‐directed storage.ConclusionsOur study shows the potential of hybrid banking as an attractive UCB storage option, as an alternative to family‐directed banking rather than a substitute for public donation. Hybrid storage potentially combines advantages of family‐directed banking as well as unrelated CB donation expanding the number of registered CB units available for transplantation and giving every pregnant woman the possibility to store UCB.
Characterization of the 263K‐derived microsomal fraction: a source of prions for nanofiltration validation studies
Authors: Simoneau Steve , Igel Angélique , Ciric Danica , Moudjou Mohammed , Tcherniuk Sergey , Béringue Vincent , Rezaei Human , Flan Benoit 
Published: May 2024

AbstractBackgroundThe manufacturing processes of plasma products include steps that can remove prions. The efficacy of these steps is measured in validation studies using animal brain‐derived prion materials called spikes. Because the nature of the prion agent in blood is not known, the relevance of these spikes, particularly with steps that are based on retention mechanisms such as nanofiltration, is important to investigate.Study Design and MethodsThe aggregation and sizes of PrPres assemblies of microsomal fractions (MFs) extracted from 263K‐infected hamster brains were analyzed using velocity gradients. The separated gradient fractions were either inoculated to Tg7 mice expressing hamster‐PrPc to measure infectivity or used in Protein Misfolding Cyclic Amplification for measuring seeding activity. The collected data allowed for reanalyzing results from previous nanofiltration validation studies.ResultsA significant portion of MFs was found to be composed of small PrPres assemblies, estimated to have a size ≤24 mers (~22–528 kDa), and to contain a minimum of 20% of total prion infectivity. With this data we could calculate reductions of 4.10 log (15 N), 2.53 log (35 N), and 1.77 log (35 N) from validation studies specifically for these small PrPres objects.ConclusionOur gradient data provided evidence that nanofilters can remove the majority of the smallest PrPres entities within microsomes spikes, estimated to be in a size below 24 mers, giving insight about the fact that, in our conditions, size exclusion may not be the only mechanism for retention nanofiltration.
Performance of artificial intelligence chatbots in interpreting clinical images of pressure injuries
Authors: Shiraishi Makoto , Kanayama Koji , Kurita Daichi , Moriwaki Yuta , Okazaki Mutsumi 
Published: May 2024

AbstractTo evaluate the accuracy of AI chatbots in staging pressure injuries according to the National Pressure Injury Advisory Panel (NPIAP) Staging through clinical image interpretation, a cross‐sectional design was conducted to assess five leading publicly available AI chatbots. As a result, three chatbots were unable to interpret the clinical images, whereas GPT‐4 Turbo achieved a high accuracy rate (83.0%) in staging pressure injuries, notably outperforming BingAI Creative mode (24.0%) with statistical significance (p < 0.001). GPT‐4 Turbo accurately identified Stages 1 (p < 0.001), 3 (p = 0.001), and 4 (p < 0.001) pressure injuries, and suspected deep tissue injuries (p < 0.001), while BingAI demonstrated significantly lower accuracy across all stages. The findings highlight the potential of AI chatbots, especially GPT‐4 Turbo, in accurately diagnosing images and aiding the subsequent management of pressure injuries.
Weak weak approximation and the Hilbert property for degree 2 del Pezzo surfaces
Authors: Demeio Julian , Streeter Sam , Winter Rosa 
Published: May 2024

AbstractWe prove that del Pezzo surfaces of degree 2 over a field satisfy weak weak approximation if is a number field and the Hilbert property if is Hilbertian of characteristic zero, provided that they contain a ‐rational point lying neither on any 4 of the 56 exceptional curves nor on the ramification divisor of the anticanonical morphism. This builds upon results of Manin, Salgado–Testa–Várilly‐Alvarado, and Festi–van Luijk on the unirationality of such surfaces, and upon work of the first two authors verifying weak weak approximation under the assumption of a conic fibration.
Stress interventions for immigrant parents in the United States: a scoping review protocol
Authors: Lo Brian K. , Park In Young , Williams Adam 
Published: May 2024

Objective:
This review will map stress interventions designed for and implemented among immigrant parents in the United States (US) according to intervention characteristics, participant characteristics, and reported outcomes and measurement tools.

Introduction:
In addition to parenting stressors shared with their non-immigrant counterparts, immigrant parents also face immigration stressors. Although stress interventions can effectively manage, reduce, or prevent stress among non-immigrant populations, we know little about stress interventions designed for immigrant parents in the US. This study will be the first to explore stress interventions implemented among immigrant parents in the US.

Inclusion criteria:
This scoping review will include published, peer-reviewed quantitative, qualitative, and mixed methods studies that evaluate stress interventions designed specifically for US immigrant parents with at least 1 child under the age of 18 years. Reported interventions must include stress as a primary or secondary outcome or be labeled as a stress intervention. Stress interventions are broadly defined, with no restrictions on the type of stress targeted (eg, job, general, parenting) or the intervention’s nature (ie, prevention vs. management/reduction vs. treatment).

Methods:
A literature search will be conducted in ProQuest’s APA PsycINFO and PsycARTICLES, CINAHL Plus (EBSCOhost), ERIC (ProQuest), Embase, MEDLINE (Ovid), International Bibliography of Social Sciences (ProQuest), and the Cochrane Library. Only English-language publications will be eligible, with no date restrictions. Retrieved titles and abstracts will be screened by at least 2 independent reviewers in duplicate. Data will be extracted using a self-developed data extraction tool. Findings will be presented in tabular or diagrammatic format, accompanied by a narrative summary.

Review registration:
Open Science Framework osf.io/ec39j