bluuebunny/crossref_metadata_2025_split huggingface dataset:
Predictors of Pain and Function in Patients With Symptomatic, Atraumatic Full-Thickness Rotator Cuff Tears
Authors: Harris Joshua D. , Pedroza Angela , Jones Grant L. ,   The MOON (Multicenter Orthopedic Outcomes Network) Shoulder Group, Baumgarten Keith M. , Bishop Julie Y. , Brophy Robert H. , Carey James L. , Dunn Warren R. , Holloway G. Brian , Kuhn John E. , Ma C. Benjamin , Marx Robert G. , McCarty Eric C. , Poddar Sourav K. , Smith Matthew V. , Spencer Edwin E. , Vidal Armando F. , Wolf Brian R. , Wright Rick W. 
Published: November 2011

Background: Although the prevalence of full-thickness rotator cuff tears increases with age, many patients are asymptomatic and may not require surgical repair. The factors associated with pain and loss of function in patients with rotator cuff tears are not well defined. Purpose: To determine which factors correlate with pain and loss of function in patients with symptomatic, atraumatic full-thickness rotator cuff tears who are enrolled in a structured physical therapy program. Study Design: Cross-sectional study; Level of evidence, 3. Methods: A multicenter group enrolled patients with symptomatic, atraumatic rotator cuff tears in a prospective, nonrandomized cohort study evaluating the effects of a structured physical therapy program. Time-zero patient data were reviewed to test which factors correlated with Western Ontario Rotator Cuff (WORC) index and American Shoulder and Elbow Surgeons (ASES) scores. Results: A total of 389 patients were enrolled. Mean ASES score was 53.9; mean WORC score was 46.9. The following variables were associated with higher WORC and ASES scores: female sex ( P = .001), education level (higher education, higher score; P < .001), active abduction (degrees; P = .021), and strength in forward elevation ( P = .002) and abduction ( P = .007). The following variables were associated with lower WORC and ASES scores: male sex ( P = .001), atrophy of the supraspinatus ( P = .04) and infraspinatus ( P = .003), and presence of scapulothoracic dyskinesia ( P < .001). Tear size was not a significant predictor (WORC) unless comparing isolated supraspinatus tears to supraspinatus, infraspinatus, and subscapularis tears ( P = .004). Age, tear retraction, duration of symptoms, and humeral head migration were not statistically significant. Conclusion: Nonsurgically modifiable factors, such as scapulothoracic dyskinesia, active abduction, and strength in forward elevation and abduction, were identified that could be addressed nonoperatively with therapy. Therefore, physical therapy for patients with symptomatic rotator cuff tears should target these modifiable factors associated with pain and loss of function.
A Magnetic Resonance Imaging Study of 100 Cases of Arthroscopic Acromioplasty
Authors: Koh Kyoung Hwan , Laddha Mukesh S. , Lim Tae Kang , Lee Jong Hyuk , Yoo Jae Chul 
Published: November 2011

Background: A hooked-type acromion has been suspected to correlate with higher rotator cuff tear or impingement syndrome. However, correlation of acromial shape after acromioplasty with the rotator cuff retears and clinical results has not been studied before. Purpose: To assess the shape of the acromion after arthroscopic acromioplasty and to see if there is any relation with the rotator cuff retears and clinical results. Study Design: Case series; Level of evidence, 4. Methods: One hundred consecutive patients who underwent acromioplasty using a posterior cutting block technique accompanied by rotator cuff repair were included in this study. The decision was made to perform acromioplasty intraoperatively after confirmation of external impingement. Postoperative acromial shape was evaluated according to whether the acromion was flat, curved, or hooked on coronal and sagittal planes on magnetic resonance imaging (MRI) at a mean 13.4 months after surgery. Retear rates and clinical scores were compared between the hooked acromion and the others on postoperative MRI. Results: Preoperatively, only 29 patients had a hooked acromion on either coronal or sagittal plane MRI. After acromioplasty of those 100 patients, 23 still showed a hooked acromion. Twenty-six of 29 preoperatively hooked acromions were changed to nonhooked acromions, and 20 of 23 postoperatively hooked acromions had been nonhooked acromions preoperatively. No difference was found in the retear rate with respect to the postoperative acromial shape. Clinically, the American Shoulder and Elbow Surgeons (ASES) score was not different between the hooked acromion and the other group (82 vs 85, P = .099). However, the Constant score of the hooked acromion group was lower than that of the other group (74 vs 85, P = .036). Ninety-four of 100 patients were contacted again for the evaluation of the ASES score at a mean 36.5 months (range, 29-45 months) and showed no difference between the hooked acromion and the other group (87 vs 87, P = .903). Conclusion: Even with a standard posterior cutting block technique during acromioplasty, 23% of patients still showed a hooked acromion after arthroscopic acromioplasty. Using the signs of coracoacromial ligament impingement as an indication for acromioplasty might lead to hooked acromions postoperatively, which were nonhooked acromions preoperatively. However, the retear rate showed no difference according to the postoperative acromial shape.
P-selectin glycoprotein ligand regulates the interaction of multiple myeloma cells with the bone marrow microenvironment
Authors: Azab Abdel Kareem , Quang Phong , Azab Feda , Pitsillides Costas , Thompson Brian , Chonghaile Triona , Patton John T. , Maiso Patricia , Monrose Val , Sacco Antonio , Ngo Hai T. , Flores Ludmila M. , Lin Charles P. , Magnani John L. , Kung Andrew L. , Letai Anthony , Carrasco Ruben , Roccaro Aldo M. , Ghobrial Irene M. 
Published: November 2011

Abstract
Interactions between multiple myeloma (MM) cells and the BM microenvironment play a critical role in the pathogenesis of MM and in the development of drug resistance by MM cells. Selectins are involved in extravasation and homing of leukocytes to target organs. In the present study, we focused on adhesion dynamics that involve P-selectin glycoprotein ligand-1 (PSGL-1) on MM cells and its interaction with selectins in the BM microenvironment. We show that PSGL-1 is highly expressed on MM cells and regulates the adhesion and homing of MM cells to cells in the BM microenvironment in vitro and in vivo. This interaction involves both endothelial cells and BM stromal cells. Using loss-of-function studies and the small-molecule pan-selectin inhibitor GMI-1070, we show that PSGL-1 regulates the activation of integrins and downstream signaling. We also document that this interaction regulates MM-cell proliferation in coculture with BM microenvironmental cells and the development of drug resistance. Furthermore, inhibiting this interaction with GMI-1070 enhances the sensitization of MM cells to bortezomib in vitro and in vivo. These data highlight the critical contribution of PSGL-1 to the regulation of growth, dissemination, and drug resistance in MM in the context of the BM microenvironment.
EBV-associated T/NK–cell lymphoproliferative diseases in nonimmunocompromised hosts: prospective analysis of 108 cases
Authors: Kimura Hiroshi , Ito Yoshinori , Kawabe Shinji , Gotoh Kensei , Takahashi Yoshiyuki , Kojima Seiji , Naoe Tomoki , Esaki Shinichi , Kikuta Atsushi , Sawada Akihisa , Kawa Keisei , Ohshima Koichi , Nakamura Shigeo 
Published: November 2011

AbstractEBV-associated T/NK–cell lymphoproliferative disease (T/NK-LPD) is defined as a systemic illness characterized by clonal proliferation of EBV-infected T or NK cells. We prospectively enrolled 108 nonimmunocompromised patients with this disease (50 men and 58 women; median onset age, 8 years; age range, 1-50 years) evidenced by expansion of EBV+ T/NK cells in the peripheral blood; these were of the T-cell type in 64 cases and of the NK-cell type in 44, and were clinically categorized into 4 groups: 80 cases of chronic active EBV disease, 15 of EBV-associated hemophagocytic lymphohistiocytosis, 9 of severe mosquito bite allergy, and 4 of hydroa vacciniforme. These clinical profiles were closely linked with the EBV+ cell immunophenotypes. In a median follow-up period of 46 months, 47 patients (44%) died of severe organ complications. During the follow-up, 13 patients developed overt lymphoma or leukemia characterized by extranodal NK/T-cell lymphoma and aggressive NK-cell leukemia. Fifty-nine received hematopoietic stem cell transplantation, 66% of whom survived. Age at onset of disease (≥ 8 years) and liver dysfunction were risk factors for mortality, whereas patients who received transplantation had a better prognosis. These data depict clinical characteristics of systemic EBV+ T/NK-LPD and provide insight into the diagnostic and therapeutic approaches for distinct disease.
RNA-Seq improves annotation of protein-coding genes in the cucumber genome
Authors: Li Zhen , Zhang Zhonghua , Yan Pengcheng , Huang Sanwen , Fei Zhangjun , Lin Kui 
Published: November 2011

Abstract

Background
As more and more genomes are sequenced, genome annotation becomes increasingly important in bridging the gap between sequence and biology. Gene prediction, which is at the center of genome annotation, usually integrates various resources to compute consensus gene structures. However, many newly sequenced genomes have limited resources for gene predictions. In an effort to create high-quality gene models of the cucumber genome (Cucumis sativus var. sativus), based on the EVidenceModeler gene prediction pipeline, we incorporated the massively parallel complementary DNA sequencing (RNA-Seq) reads of 10 cucumber tissues into EVidenceModeler. We applied the new pipeline to the reassembled cucumber genome and included a comparison between our predicted protein-coding gene sets and a published set.

Results
The reassembled cucumber genome, annotated with RNA-Seq reads from 10 tissues, has 23, 248 identified protein-coding genes. Compared with the published prediction in 2009, approximately 8, 700 genes reveal structural modifications and 5, 285 genes only appear in the reassembled cucumber genome. All the related results, including genome sequence and annotations, are available at http://cmb.bnu.edu.cn/Cucumis_sativus_v20/.

Conclusions
We conclude that RNA-Seq greatly improves the accuracy of prediction of protein-coding genes in the reassembled cucumber genome. The comparison between the two gene sets also suggests that it is feasible to use RNA-Seq reads to annotate newly sequenced or less-studied genomes.
Adjunctive long-acting risperidone in patients with bipolar disorder who relapse frequently and have active mood symptoms
Authors: Macfadden Wayne , Adler Caleb M , Turkoz Ibrahim , Haskins John T , Turner Norris , Alphs Larry 
Published: November 2011

Abstract

Background
The objective of this exploratory analysis was to characterize efficacy and onset of action of a 3-month treatment period with risperidone long-acting injection (RLAI), adjunctive to an individual's treatment regimen, in subjects with symptomatic bipolar disorder who relapsed frequently and had significant symptoms of mania and/or depression.

Methods
Subjects with bipolar disorder with ≥4 mood episodes in the past 12 months entered the open-label stabilization phase preceding a placebo-controlled, double-blind study. Subjects with significant depressive or manic/mixed symptoms at baseline were analyzed. Significant depressive symptoms were defined as Montgomery-Åsberg Depression Rating Scale (MADRS) ≥16 and Young Mania Rating Scale (YMRS) < 16; manic/mixed symptoms were YMRS ≥16 with any MADRS score. Subjects received open-label RLAI (25-50 mg every 2 weeks) for 16 weeks, adjunctive to a subject's individualized treatment for bipolar disorder (mood stabilizers, antidepressants, and/or anxiolytics). Clinical status was evaluated with the Clinical Global Impressions of Bipolar Disorder-Severity (CGI-BP-S) scale and changes on the MADRS and YMRS scales. Within-group changes were evaluated using paired t tests; categorical differences were assessed using Fisher exact test. No adjustment was made for multiplicity.

Results
162 subjects who relapsed frequently met criteria for significant mood symptoms at open-label baseline; 59/162 (36.4%) had depressive symptoms, 103/162 (63.6%) had manic/mixed symptoms. Most subjects (89.5%) were receiving ≥1 medication for bipolar disorder before enrollment. Significant improvements were observed for the total population on the CGI-BP-S, MADRS, and YMRS scales (p < .001 vs. baseline, all variables). Eighty-two (53.3%) subjects achieved remission at the week 16 LOCF end point. The subpopulation with depressive symptoms at open-label baseline experienced significant improvement on the CGI-BP-S and MADRS scales (p < .001 vs. baseline, all variables). Subjects with manic/mixed symptoms at baseline had significant improvements on the CGI-BP-S and YMRS scales (p < .001 vs. baseline, all variables). No unexpected tolerability findings were observed.

Conclusions
Exploratory analysis of changes in overall clinical status and depression/mania symptoms in subjects with symptomatic bipolar disorder who relapse frequently showed improvements in each of these areas after treatment with RLAI, adjunctive to a subject's individualized treatment. Prospective controlled studies are needed to confirm these findings.
Interventions to improve work outcomes in work-related PTSD: a systematic review
Authors: Stergiopoulos Erene , Cimo Adriana , Cheng Chiachen , Bonato Sarah , Dewa Carolyn S 
Published: November 2011

Abstract

Background
Posttraumatic stress disorder acquired at work can be debilitating both for workers and their employers. The disorder can result in increased sick leave, reduced productivity, and even unemployment. Furthermore, workers are especially unlikely to return to their previous place of employment after a traumatic incident at work because of the traumatic memories and symptoms of avoidance that typically accompany the disorder. Therefore, intervening in work-related PTSD becomes especially important in order to get workers back to the workplace.

Methods
A systematic literature search was conducted using Medline, PsycINFO, Embase, and Web of Science. The articles were independently screened based on inclusion and exclusion criteria, followed by a quality assessment of all included articles.

Results
The systematic search identified seven articles for inclusion in the review. These consisted of six research articles and one systematic review. The review focused specifically on interventions using real exposure techniques for anxiety disorders in the workplace. In the research articles addressed in the current review, study populations included police officers, public transportation workers, and employees injured at work. The studies examined the effectiveness of EMDR, cognitive-behavioural techniques, and an integrative therapy approach called brief eclectic psychotherapy. Interestingly, 2 of the 6 research articles addressed add-on treatments for workplace PTSD, which were designed to treat workers with PTSD who failed to respond to traditional evidence-based psychotherapy.

Conclusions
Results of the current review suggest that work-related interventions show promise as effective strategies for promoting return to work in employees who acquired PTSD in the workplace. Further research is needed in this area to determine how different occupational groups with specific types of traumatic exposure might respond differently to work-tailored treatments.
Projection to latent pathways (PLP): a constrained projection to latent variables (PLS) method for elementary flux modes discrimination
Authors: Ferreira Ana R , Dias João ML , Teixeira Ana P , Carinhas Nuno , Portela Rui MC , Isidro Inês A , von Stosch Moritz , Oliveira Rui 
Published: November 2011

Abstract

Background
Elementary flux modes (EFM) are unique and non-decomposable sets of metabolic reactions able to operate coherently in steady-state. A metabolic network has in general a very high number of EFM reflecting the typical functional redundancy of biological systems. However, most of these EFM are either thermodynamically unfeasible or inactive at pre-set environmental conditions.

Results
Here we present a new algorithm that discriminates the "active" set of EFM on the basis of dynamic envirome data. The algorithm merges together two well-known methods: projection to latent structures (PLS) and EFM analysis, and is therefore termed projection to latent pathways (PLP). PLP has two concomitant goals: (1) maximisation of correlation between EFM weighting factors and measured envirome data and (2) minimisation of redundancy by eliminating EFM with low correlation with the envirome.

Conclusions
Overall, our results demonstrate that PLP slightly outperforms PLS in terms of predictive power. But more importantly, PLP is able to discriminate the subset of EFM with highest correlation with the envirome, thus providing in-depth knowledge of how the environment controls core cellular functions. This offers a significant advantage over PLS since its abstract structure cannot be associated with the underlying biological structure.
Effects of paraoxonase activity and gene polymorphism on coronary vasomotion
Authors: Dunet Vincent , Ruiz Juan , Allenbach Gilles , Izzo Paola , James Richard W , Prior John O 
Published: November 2011

Abstract

Background
Paraoxonase 1 [PON1] is recognized as a protective enzyme against LDL oxidation, and PON1 polymorphism has been described as a factor influencing coronary heart disease [CHD] free survival. As coronary vasoreactivity is a surrogate of future cardiovascular events, we aimed at assessing the respective effect of the PON1 genotype and activity on coronary vasoreactivity in a population of type 2 diabetic patients.

Methods
Nineteen patients with type 2 diabetes mellitus underwent 82Rb cardiac PET/CT to quantify myocardial blood flow [MBF] at rest, during cold pressor testing [CPT], and during adenosine-induced hyperaemia to compute myocardial flow reserve [MFR]. They were allocated according to Q192R and L55M polymorphisms into three groups (wild-type and LM/QR heterozygotes, MM homozygotes, and RR homozygotes) and underwent a measurement of plasmatic PON1 activity. Relations between rest-MBF, stress-MBF, MFR, and MBF response to CPT and PON1 genotypes and PON1 activity were assessed using Spearman's correlation and multivariate linear regression analysis.

Results
Although PON1 activity was significantly associated with PON1 polymorphism (p < 0.0001), there was no significant relation between the PON1 genotypes and the rest-MBF, stress-MBF, or MBF response to CPT (p ≥ 0.33). The PON1 activity significantly correlated with the HDL plasma level (ρ = 0.63, p = 0.005), age (ρ = -0.52, p = 0.027), and MFR (ρ = 0.48, p = 0.044). Moreover, on multivariate analysis, PON1 activity was independently associated with MFR (p = 0.037).

Conclusion
Our study supports an independent association between PON1 activity and MFR. Whether PON1 contributes to promote coronary vasoreactivity through its antioxidant activity remains to be elucidated. This putative mechanism could be the basis of the increased risk of CHD in patients with low PON1 activity.
Further Improvement in Quantifying Male Fetal DNA in Maternal Plasma
Authors: Jin Shengnan , Lin Xueqin Michelle , Law Haiyang , Kwek Kenneth Y C , Yeo George S H , Ding Chunming 
Published: November 2011

Abstract

BACKGROUND
Cell-free fetal DNA (cffDNA) in maternal plasma can be clinically useful for detecting prenatal disorders and pregnancy monitoring. More sensitive, specific, and quantitative detection of cffDNA in maternal plasma may expand the clinical utility of such measurements.

METHODS
We developed a quantitative real-time PCR (qPCR) assay [Y chromosome repetitive sequence (YRS) assay] based on a highly repetitive short sequence specific for the Y chromosome. Both standard qPCR and digital qPCR were performed to compare the sensitivity and specificity of this new assay against already established male DNA–specific assays.

RESULTS
The YRS assay was at least 10-fold more sensitive than the currently most sensitive DYS14 assay. The YRS assay was able to detect 0.5 genome equivalents (GE) per PCR reaction when fetal DNA was present at 0.2% of the total DNA. The background noise for the YRS assay was much lower than for the DYS14 assay in analyses of plasma samples from pregnancies with female fetuses.

CONCLUSIONS
The YRS assay is a substantial improvement for quantifying rare male fetal DNA in maternal plasma. The higher sensitivity and specificity may expand the clinical and research utility of cffDNA.
Theatres for Hire
Authors: Slater William J. 
Published: November 2011

Abstract
The Piraeus were certainly leased out to private individuals in classical antiquity. It has been suggested that this was common and was true even for the Theatre of Dionysus in Athens, and that this model was true for impermanent wooden theatres. This article argues a contrary position: that there is only one certain example of a leased theatre, which may for all we know have been unique. The other alleged parallel, the deme theatre in Acharnae, is argued to be wrongly supplemented and explained. Some other epigraphical examples of theatres are cited for different funding mechanisms, and it is also argued that wooden theatres were neither leased nor necessarily impermanent. We have especially no reason to think that the Theatre of Dionysus was leased in the time of Theophrastus.
L’eccidio degli uomini a Lemno. Il modello delle Argonautiche di Apollonio Rodio e la sua rifunzionalizzazione in Quinto Smirneo Posthomerica 9, 338–352
Authors: Ozbek Leyla 
Published: November 2011

Abstract
Quintus Smyrnaeus’ Posthomerica 9, 338–352 deals with the most famous Λήμνιον κακόν of the ancient myths: the women of Lemnos, jealous of the relationships between their husbands and some Thracian slaves, killed all the male population of the island. Quintus’ story uses as an intertextual model Apollonius Rhodius’ Argonautica 1, 609–632, dealing with the same episode (which is partly repeated, with some differences, in 1, 793–826). The aim of this paper is not only to show the intertextual relationship between Quintus’ and Apollonius’ texts, but also to show how Quintus changes the innovative point of view of Apollonius (who reduces the women’s guilt, blaming the husbands) in order to come back to the traditional “masculinist” point of view. In doing so Quintus inserts in his text some fundamental details (both lexical and narrative) of Apollonius’ version, but he ingeniously modifies their functions or meanings in order to remind the readers both of Apollonius’ version and of the changes he made to it.
Pyrrha oder Der versteckte Achilles. Ein horazisches Motiv im Licht sequenzieller Lektüre
Authors: Felgentreu Fritz 
Published: November 2011

Abstract
A sequential reading of Horace’s Odes shows that the Pyrrha poem (1. 5) is connected with various others by means of subject matter, structure, choice of words, and metre. In the centre of this complex of allusions we find the figure of Achilles in the transvestite disguise he used to hide on the island of Scyrus, where, according to Hyginus, he was known by the name of Pyrrha. In the epic tradition, Scyrus seems to have been counted among the Cycladic Isles, while at the same time, that particular episode in the hero’s life belongs to the period narrated in the epic cycle. Through this connection, the Scyrian Achilles may shed light on the meaning of Horace’s warning against travelling the sea that extends between the Cyclades in ode 1. 14, the first ode written in the same metre as 1. 5. In the final part of the article, Horace’s allusive technique, described by him in metaphors of weaving and spinning, is compared to the modern concept of the leitmotif.