bluuebunny/crossref_metadata_2025_split huggingface dataset:
Model predictive control (MPC) applied to a simplified model, magnetic nanoparticle hyperthermia (MNPH) treatment process
Authors: Abu-Ayyad Ma’Moun , Lad Yash Sharad , Aguilar Dario , Karami Kiana , Attaluri Anilchandra 
Published: May 2024

Abstract
Magnetic nanoparticle hyperthermia (MNPH) has emerged as a promising cancer treatment that complements conventional ionizing radiation and chemotherapy. MNPH involves injecting iron-oxide nanoparticles into the tumor and exposing it to an alternating magnetic field (AMF). Iron oxide nanoparticles produce heat when exposed to radiofrequency AMF due to hysteresis loss. Minimizing the non-specific heating in human tissues caused by exposure to AMF is crucial. A pulse-width-modulated AMF has been shown to minimize eddy-current heating in superficial tissues. This project developed a control strategy based on a simplified mathematical model in MATLAB SIMULINK® to minimize eddy current heating while maintaining a therapeutic temperature in the tumor. A minimum tumor temperature of 43 [°C] is required for at least 30 [min] for effective hyperthermia, while maintaining the surrounding healthy tissues below 39 [°C]. A model predictive control (MPC) algorithm was used to reach the target temperature within approximately 100 [s]. As a constrained MPC approach, a maximum AMF amplitude of 36 [kA/m] and increment of 5 [kA/m/s] were applied. MPC utilized the AMF amplitude as an input and incorporated the open-loop response of the eddy current heating in its dynamic matrix. A conventional proportional integral (PI) controller was implemented and compared with the MPC performance. The results showed that MPC had a faster response (30 [s]) with minimal overshoot (1.4 [%]) than PI controller (115 [s] and 5.7 [%]) response. In addition, the MPC method performed better than the structured PI controller in its ability to handle constraints and changes in process parameters.
RFPID: development and 3D-printing of a female physical phantom for whole-body counter
Authors: Andrade E M R , Paixão L , Mendes B M , Fonseca T C F 
Published: May 2024

Abstract
Whole-body counters (WBC) are used in internal dosimetry for in vivo monitoring in radiation protection. The calibration processes of a WBC set-up include the measurement of a physical phantom filled with a certificate radioactive source that usually is referred to a standard set of individuals determined by the International Commission on Radiological Protection (ICRP). The aim of this study was to develop an anthropomorphic and anthropometric female physical phantom for the calibration of the WBC systems. The reference female computational phantom of the ICRP, now called RFPID (Reference Female Phantom for Internal Dosimetry) was printed using PLA filament and with an empty interior. The goal is to use the RFPID to reduce the uncertainties associated with in vivo monitoring system. The images which generated the phantom were manipulated using ImageJ®, Amide®, GIMP® and the 3D Slicer® software. RFPID was split into several parts and printed using a 3D printer in order to print the whole-body phantom. The newly printed physical phantom RFPID was successfully fabricated, and it is suitable to mimic human tissue, anatomically similar to a human body i.e., size, shape, material composition, and density.
Comparing discriminating abilities of evaluation metrics in link prediction
Authors: Jiao Xinshan , Wan Shuyan , Liu Qian , Bi Yilin , Lee Yan-Li , Xu En , Hao Dong , Zhou Tao 
Published: May 2024

AbstractLink prediction aims to predict the potential existence of links between two unconnected nodes within a network based on the known topological characteristics. Evaluation metrics are used to assess the effectiveness of algorithms in link prediction. The discriminating ability of these evaluation metrics is vitally important for accurately evaluating link prediction algorithms. In this study, we propose an artificial network model, based on which one can adjust a single parameter to monotonically and continuously turn the prediction accuracy of the specifically designed link prediction algorithm. Building upon this foundation, we show a framework to depict the effectiveness of evaluating metrics by focusing on their discriminating ability. Specifically, a quantitative comparison in the abilities of correctly discerning varying prediction accuracies was conducted encompassing nine evaluation metrics: Precision, Recall, F1-Measure, Matthews correlation coefficient, balanced precision, the area under the receiver operating characteristic curve (AUC), the area under the precision-recall curve (AUPR), normalized discounted cumulative gain (NDCG), and the area under the magnified receiver operating characteristic. The results indicate that the discriminating abilities of the three metrics, AUC, AUPR, and NDCG, are significantly higher than those of other metrics.
Litigating Climate Change in the Global South
Authors: Lin Jolene , Peel Jacqueline 
Published: May 2024

Abstract
This introductory chapter outlines the approach and structure of the book. It explains how the book’s study of Global South climate litigation has been scoped and undertaken. This includes discussion of: (1) the international law and governance context in which climate litigation is occurring and how this case law might contribute to global climate governance; (2) the understanding of the ‘Global South’ adopted in the book and why this terminology has been used; (3) how the book has approached the definition of climate litigation; and (4) the application of this definition in the book’s methodology for the selection and analysis of Global South cases.
The Global South Climate Litigation Docket
Authors: Lin Jolene , Peel Jacqueline 
Published: May 2024

Abstract
This chapter provides a comprehensive examination of cases in the ‘Global South docket’. In analyses 128 cases filed, pending decision, or decided in Global South countries up to May 2023. The chapter identifies key trends across the case law, including the more pronounced use of rights-based arguments in cases in the Global South, and common characteristics of the Global South docket such as the preference for implementing ‘law on the books’. The final part of the chapter discusses transnational cases—ones brought in Global North courts but involving Global South plaintiffs or projects—which can be the basis for creating truly transnational coalitions of actors seeking accountability from Global North governments and corporations for their failure to reduce greenhouse gas emissions and decarbonize their economic activities.
The King Can Do No Wrong
Authors: Fortin Marie-France 
Published: May 2024

Abstract
This book traces the evolution of the king can do no wrong in legal thinking to revisit our current understanding of crown liability. Arguing that the king can do no wrong is one of the most fundamental yet most misunderstood ideas of the common law tradition, the book describes ways in which these misunderstandings have serious consequences, most dramatically by making it difficult—and sometimes impossible—for individuals to successfully sue the state for the harm caused to them by governmental institutions. This book offers a novel framework for understanding the core features of legal thinking on crown liability as they developed historically. The book delves deep into traditional legal sources to develop an intellectual history of a key legal idea. The different meanings conveyed by the king can do no wrong in the common law world are explained and the contradictions between them are revealed. The mutation from the king can do no wrong to the crown can do no wrong is brought to light, and the resulting departure from core constitutional tenets is discussed. The study of the evolution of the king can do no wrong in English legal thinking, mirrored in Canada, is complemented by a historical comparative analysis of the idea in Australia, Ireland, and the United States, including its relationship with sovereign immunity. By retracing the historical constitutional foundations of the king can do no wrong, this book enhances academics’, students’, practitioners’, and judges’ understanding of the law of governmental liability in the common law world and its relationship with constitutional fundamentals.
Shuffle Along . . . the Campaign Trail
Authors: Preston Carrie J 
Published: May 2024

Abstract
Why did George C. Wolfe’s much-anticipated Shuffle Along, or the Making of the Musical Sensation of 1921 and All That Followed close early and at a loss in the spring of 2016 while Lin-Manuel Miranda’s Hamilton soared to beat its own records for awards and ticket sales? This chapter argues that audiences were not interested in the complex and relatively untold history of the making of African American performance traditions with their accommodations to racism (including blackface minstrelsy) and the very performance styles and innovations that influenced Hamilton’s blockbuster style. The 1921 Shuffle Along that Wolfe revived has been forgotten, in part, because it does not fit comfortably into contemporary visions of theater history and American diversity and inclusion. Shuffle Along, or the Making of . . . is being forgotten because it clarifies the limitations of current appeals to diversity when they do not attend to the historical record, previous racial justice movements, and the many ways the laudable goal of diversity ends up twisted and coopted to support white supremacy.
Effect of a Hypertensive Response During Exercise on Growth Rates of Aortic Diameters
Authors: van der Stouwe Jan Gerrit , Rossi Valentina A , Ghidoni Céline , Würzburger Laura , Wiech Patrick , Schweiger Victor , Petrasch Gloria , Moser Georg , Schmied Christian M , Vontobel Jan , Caselli Stefano , Niederseer David 
Published: May 2024

Abstract

BACKGROUND
Aortic diameters are related to age, sex, and body size. There is a scarcity of data on the long-term sequelae of a hypertensive response to exercise (HRE) on aortic diameters. In this retrospective cohort study, we aimed to evaluate the relationship between the growth rates of the aorta in individuals with a HRE.

METHODS
Our analysis included follow-up data of 649 patients recruited between January 2009 and December 2014 with a HRE. Participants with known connective tissue disease or a history of acute aortic syndrome were excluded. Sinus of Valsalva (SoV) and ascending aorta (AscAo) diameters were measured by transthoracic echocardiography using leading edge to leading edge convention at end-diastole.

RESULTS
At baseline, median age, maximum systolic blood pressure (BP), body mass index (BMI), diameter of the SoV, and AscAo were 62 years, 208 mm Hg, 26.9 kg/m2, 35 mm, and 35 mm respectively. 32% of patients were female and 67% had hypertension. After a median follow-up of 7.1 years, mean yearly growth rates (±SD) of the SoV and AscAo were 0.09 (0.41) mm and 0.13 (0.56) mm, respectively. No significant associations were observed between growth rates of aortic diameters and maximum systolic and diastolic BP or when considering only individuals with a baseline diameter &gt;40 mm.

CONCLUSIONS
In this large cohort study, maximum systolic and diastolic BP during exercise showed no association with growth rates of aortic diameters. Furthermore, the mean growth rates of aortic diameters in this population were in line with growth rates in a normal population.
Scalable integration of multiomic single-cell data using generative adversarial networks
Authors: Giansanti Valentina , Giannese Francesca , Botrugno Oronza A , Gandolfi Giorgia , Balestrieri Chiara , Antoniotti Marco , Tonon Giovanni , Cittaro Davide 
Published: May 2024

Abstract

Motivation
Single-cell profiling has become a common practice to investigate the complexity of tissues, organs, and organisms. Recent technological advances are expanding our capabilities to profile various molecular layers beyond the transcriptome such as, but not limited to, the genome, the epigenome, and the proteome. Depending on the experimental procedure, these data can be obtained from separate assays or the very same cells. Yet, integration of more than two assays is currently not supported by the majority of the computational frameworks avaiable.

Results
We here propose a Multi-Omic data integration framework based on Wasserstein Generative Adversarial Networks suitable for the analysis of paired or unpaired data with a high number of modalities (&gt;2). At the core of our strategy is a single network trained on all modalities together, limiting the computational burden when many molecular layers are evaluated.

Availability and implementation
Source code of our framework is available at https://github.com/vgiansanti/MOWGAN
Contribution of the seminal microbiome to paternal programming
Authors: Kilama Justine , Dahlen Carl R , Reynolds Lawrence P , Amat Samat 
Published: May 2024

Abstract
The field of Developmental Origins of Health and Disease has primarily focused on maternal programming of offspring health. However, emerging evidence suggests that paternal factors, including the seminal microbiome, could potentially play important roles in shaping the developmental trajectory and long-term offspring health outcomes. Historically, the microbes present in the semen were regarded as inherently pathogenic agents. However, this dogma has recently been challenged by the discovery of a diverse commensal microbial community within the semen of healthy males. In addition, recent studies suggest that the transmission of semen-associated microbes into the female reproductive tract during mating has potentials to not only influence female fertility and embryo development but could also contribute to paternal programming in the offspring. In this review, we summarize the current knowledge on the seminal microbiota in both humans and animals followed by discussing their potential involvement in paternal programming of offspring health. We also propose and discuss potential mechanisms through which paternal influences are transmitted to offspring via the seminal microbiome. Overall, this review provides insights into the seminal microbiome-based paternal programing, which will expand our understanding of the potential paternal programming mechanisms which are currently focused primarily on the epigenetic modifications, oxidative stresses, and cytokines.
One case of myxoid glioneuronal tumour in the left frontal lobe
Authors: Chu Jiayi , Hu Sheng , Wang Gangping , Hu Jibo , Xiao Wenbo 
Published: May 2024

Abstract
Myxoid glioneuronal tumour (MGNT), previously described as dysembryoplastic neuroepithelial tumour of the septum pellucidum, was classified as a new tumour type in the fifth edition of the WHO Central Nervous System Tumor Classification of 2021. This classification was based on its anatomical location, imaging features, and genetic characteristics. MGNTs are clinically rare and prone to misdiagnosis. In this report, we present a case of MGNT in the left frontal lobe, which was confirmed through surgical pathology.
Impact on in-depth immunophenotyping of delay to peripheral blood processing
Authors: Higdon Lauren E , Scheiding Sheila , Kus Anna M , Lim Noha , Long S Alice , Anderson Mark S , Wiedeman Alice E 
Published: May 2024

Abstract
Peripheral blood mononuclear cell (PBMC) immunophenotyping is crucial in tracking activation, disease state, and response to therapy in human subjects. Many studies require the shipping of blood from clinical sites to a laboratory for processing to PBMC, which can lead to delays that impact sample quality. We used an extensive cytometry by time-of-flight (CyTOF) immunophenotyping panel to analyze the impacts of delays to processing and distinct storage conditions on cell composition and quality of PBMC from seven adults across a range of ages, including two with rheumatoid arthritis. Two or more days of delay to processing resulted in extensive red blood cell contamination and increased variability of cell counts. While total memory and naïve B- and T-cell populations were maintained, 4-day delays reduced the frequencies of monocytes. Variation across all immune subsets increased with delays of up to 7 days in processing. Unbiased clustering analysis to define more granular subsets confirmed changes in PBMC composition, including decreases of classical and non-classical monocytes, basophils, plasmacytoid dendritic cells, and follicular helper T cells, with each subset impacted at a distinct time of delay. Expression of activation markers and chemokine receptors changed by Day 2, with differential impacts across subsets and markers. Our data support existing recommendations to process PBMC within 36 h of collection but provide guidance on appropriate immunophenotyping experiments with longer delays.
Deformation of transfersomes dispersed in hydrated deep eutectic solvent in stratum corneum
Authors: Takada Amika , Matsuoka Misato , Sakuragi Mina 
Published: May 2024

Abstract
The deformation of transfersomes (TFs) dispersed in deep eutectic solvents and applied to the stratum corneum (SC) was evaluated by small-angle X-ray scattering. We found that TFs permeated the SC, while the regularity and period of the multilayer structure of TFs deformed significantly, depending on the SC location and the time after application.
Determination of Azole Fungicide Residues in Fresh Juice by Magnetic Solid Phase Extraction Based on Fe3O4@ZnAl-LDH@MIL-53(Al) Sorbent in Combination with High-Performance Liquid Chromatograph
Authors: Yang Shu-Tong , Cao Yi-Wen , Zeng Zi-Ying , Gang Zheng , Chen Min , Du Bing-Yan , Su Miao-Miao , Yang Zhong-Hua , Tang Zhu-Hua , Zeng Yun-Liu 
Published: May 2024

Abstract
In this work, a magnetic adsorption material based on metal–organic framework (Fe3O4@ZnAl-LDH@MIL-53(Al)) was synthesized and used as an adsorbent in the process of magnetic solid phase extraction. Then, a high-performance liquid chromatograph was used to quantitatively detect triazole fungicides in samples. In order to verify the successful preparation of the material, a series of characterization analyses were carried out. Besides, the key parameters that may affect the extraction efficiency have been optimized, and under optimal conditions the three triazole fungicides showed good linearity in the range of 10–1000 μg/L (R2 ≥ 0.9796); Limit of detections were ranged from 0.013 to 0.030 μg/mL. Finally, the established method was applied to the detection of triazole fungicides in four fresh juice samples. The results showed that the target analyte was not detected in all the test samples. By detecting the recoveries (73.3–104.3%) and coefficient variation (RSD ≤ 6.8%) of triazole fungicides in fortified samples, it proved that this established method meets the requirements of pesticide residue analysis and showed excellent application potential.
A nox2/cybb zebrafish mutant with defective myeloid cell reactive oxygen species production displays normal initial neutrophil recruitment to sterile tail injuries
Authors: Isiaku Abdulsalam I , Zhang Zuobing , Pazhakh Vahid , Lieschke Graham J 
Published: May 2024

Abstract
Reactive oxygen species are important effectors and modifiers of the acute inflammatory response, recruiting phagocytes including neutrophils to sites of tissue injury. In turn, phagocytes such as neutrophils are both consumers and producers of reactive oxygen species. Phagocytes including neutrophils generate reactive oxygen species in an oxidative burst through the activity of a multimeric phagocytic nicotinamide adenine dinucleotide phosphate oxidase complex. Mutations in the NOX2/CYBB (previously gp91phox) nicotinamide adenine dinucleotide phosphate oxidase subunit are the commonest cause of chronic granulomatous disease, a disease characterized by infection susceptibility and an inflammatory phenotype. To model chronic granulomatous disease, we made a nox2/cybb zebrafish (Danio rerio) mutant and demonstrated it to have severely impaired myeloid cell reactive oxygen species production. Reduced early survival of nox2 mutant embryos indicated an essential requirement for nox2 during early development. In nox2/cybb zebrafish mutants, the dynamics of initial neutrophil recruitment to both mild and severe surgical tailfin wounds was normal, suggesting that excessive neutrophil recruitment at the initiation of inflammation is not the primary cause of the “sterile” inflammatory phenotype of chronic granulomatous disease patients. This nox2 zebrafish mutant adds to existing in vivo models for studying reactive oxygen species function in myeloid cells including neutrophils in development and disease.
Hearing Impairment and Physical Activity and Physical Functioning in Older Adults: Baseline Results From the ACHIEVE Trial
Authors: Cai Yurun , Martinez-Amezcua Pablo , Betz Joshua F , Zhang Talan , Huang Alison R , Wanigatunga Amal A , Glynn Nancy W , Burgard Sheila , Chisolm Theresa H , Coresh Josef , Couper David , Deal Jennifer A , Gmelin Theresa , Goman Adele M , Gravens-Mueller Lisa , Hayden Kathleen M , Mitchell Christine M , Mosley Thomas , Pankow James S , Pike James R , Reed Nicholas S , Sanchez Victoria A , Lin Frank R , Schrack Jennifer A ,   for the ACHIEVE Collaborative Research Group
Published: May 2024

Abstract

Background
Hearing loss is associated with restricted physical activity (PA) and impaired physical functioning, yet the relationship between severity of hearing impairment (HI) and novel PA measures in older adults with untreated HI is not well understood.

Methods
Analyses included 845 participants aged ≥70 years (mean = 76.6 years) with a better-hearing ear pure-tone average (PTA) ≥30 and &lt;70 dB in the Aging and Cognitive Health Evaluation in Elders (ACHIEVE) study who wore an ActiGraph accelerometer for 7 days. Physical functioning measures included grip strength and the Short Physical Performance Battery (SPPB). Linear regression models estimated the association by HI level (moderate or greater [PTA ≥ 40 dB] vs mild [PTA &lt; 40 dB]) and continuous hearing with total daily activity counts, active minutes/day, activity fragmentation, grip strength, and gait speed. Logistic regression models estimated odds ratios (ORs) and 95% confidence intervals (CIs) of poor performance on the SPPB (≤6) and its subtests (≤2). Mixed-effects models estimated differences by HI level in activity by time of day.

Results
Participants with moderate or greater HI had poorer physical functioning, particularly balance (OR = 2.17, 95% CI = 1.29–3.67), versus those with mild impairment. There was no association of HI level with activity quantities or fragmentation. For diurnal patterns of activity, participants with moderate or greater HI had fewer activity counts in the afternoon (12:00 pm –05:59 pm).

Conclusions
Older adults with worse hearing had shifted diurnal patterns and poorer balance performance. Exercise programs should be tailored to older adults with different levels of HI to maintain PA and physical functioning, particularly balance control.