bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Role of Vibrators in Women’s Pelvic Health: An Alluring Tool to Improve Physical, Sexual, and Mental Health
Authors: Dubinskaya Alexandra , Kohli Priya , Shoureshi Poone , Breese Catherine , Scott Victoria , Anger Jennifer T. , Eilber Karyn S. 
Published: April 2024

Abstract
Introduction and hypothesis
In limited studies vibrators have been shown to improve sexual function and pelvic floor health; however, there are even fewer studies on the effect of vibrator use on overall genitourinary and mental health. To investigate the effect of regular vibrator use on sexual, genitourinary, and mental health in addition to quality of life.

Methods
We performed a prospective pilot study of women aged 18 to 80 years recruited from a urogynecology clinic. Study participants were instructed to use a vibrator according to the protocol. Sexual function, pelvic floor function, mental health, and pelvic examination were assessed at the initial visit and at 3 months’ follow-up using validated questionnaires.

Results
Of the 79 participants enrolled in the study, 53 women (66%) completed the study. The mean age of the participants was 54.7 years (range 19–80 years), and the majority of participants were white (n = 59, 74.7%), post-menopausal (n = 48, 60.8%), and not receiving systemic (n = 63, 79.7%) or local (n = 63, 79.7%) hormone therapy. Sexual function significantly improved over time (p = 0.002), whereas the rate of bothersome pelvic organ prolapse symptoms and pain scores significantly decreased (p = 0.034 and 0.0008 respectively). Rates of urge urinary incontinence decreased although this was not statistically significant (p = 0.059). There was a significant improvement in the gross appearance of lichen sclerosus lesions (p = 0.025) and in the severity of vaginal atrophy (p = 0.018). Rates of depression were significantly decreased (p = 0.011).

Conclusions
Vibrator use was associated with improved sexual, genitourinary, and mental health.
Hyperbolicity and bounded-valued cohomology
Authors: Petrosyan Nansen , Vankov Vladimir 
Published: April 2024

AbstractWe generalise a theorem of Gersten on surjectivity of the restriction map in $$\ell ^{\infty }$$

ℓ
∞

-cohomology of groups. This leads to applications on subgroups of hyperbolic groups, quasi-isometric distinction of finitely generated groups and $$\ell ^{\infty }$$

ℓ
∞

-cohomology calculations for some well-known classes of groups. Along the way, we obtain hyperbolicity criteria for groups of type $$FP_2({{\mathbb {Q}}})$$

F

P
2

(
Q
)

and for those satisfying a rational homological linear isoperimetric inequality, answering a question of Arora and Martínez-Pedroza.
Bone marrow disease in rhabdomyosarcoma visualized by 2-[18F]fluorodeoxyglucose positron emission tomography/computed tomography
Authors: Kröning Pia , Berg Sebastian , Freitag Martin T , Schoot Reineke A , Fischer Alexandra , Puzik Alexander , Feuchtinger T , Niemeyer Charlotte , Meyer Philipp Tobias , Uhl Markus , Hettmer Simone 
Published: April 2024

AbstractBone marrow metastases—noted in 6% of patients with rhabdomyosarcoma—have been linked to very poor outcomes. Bilateral bone marrow sampling from iliac crests has been the gold standard for bone marrow examination in rhabdomyosarcoma, but sampling errors due to patchy bone marrow involvement may limit its sensitivity. Here, we report the case of a 6-year-old boy with embryonal rhabdomyosarcoma of the skull base and multiple 2-[18F]fluoro-2-deoxy-D-glucose (2-[18F]FDG)-avid bone marrow metastases visualized by positron emission tomography and computed tomography (2-[18F]FDG PET/CT). His bone marrow aspirates were tumor-free. This case illustrates the diagnostic value of 2-[18F]FDG PET/CT in the detection of bone marrow metastases in rhabdomyosarcoma patients, which may re-shape the definition of bone marrow disease and, ultimately, alter disease staging and risk stratification.
An immuno-epidemiological model with waning immunity after infection or vaccination
Authors: Angelov Georgi , Kovacevic Raimund , Stilianakis Nikolaos I. , Veliov Vladimir M. 
Published: April 2024

AbstractIn epidemics, waning immunity is common after infection or vaccination of individuals. Immunity levels are highly heterogeneous and dynamic. This work presents an immuno-epidemiological model that captures the fundamental dynamic features of immunity acquisition and wane after infection or vaccination and analyzes mathematically its dynamical properties. The model consists of a system of first order partial differential equations, involving nonlinear integral terms and different transfer velocities. Structurally, the equation may be interpreted as a Fokker-Planck equation for a piecewise deterministic process. However, unlike the usual models, our equation involves nonlocal effects, representing the infectivity of the whole environment. This, together with the presence of different transfer velocities, makes the proved existence of a solution novel and nontrivial. In addition, the asymptotic behavior of the model is analyzed based on the obtained qualitative properties of the solution. An optimal control problem with objective function including the total number of deaths and costs of vaccination is explored. Numerical results describe the dynamic relationship between contact rates and optimal solutions. The approach can contribute to the understanding of the dynamics of immune responses at population level and may guide public health policies.
A novel classification of posterior pelvic exenteration to assess prognosis in female patients with locally advanced primary rectal cancer: a retrospective cohort study from China PelvEx collaborative
Authors: Li Yuegang , Zhuang Meng , Hu Gang , Zhang Jinzhu , Qiu Wenlong , Mei Shiwen , Tang Jianqiang 
Published: April 2024

Abstract
Purpose
Surgical techniques and the prognosis of posterior pelvic exenteration for locally advanced primary rectal cancer in female patients pose challenges that need to be addressed. Therefore, we investigated the short-term and survival outcomes of posterior pelvic exenteration in female patients using a novel Peking classification.

Methods
We retrospectively analysed a prospective database from China PelvEx Collaborative across three tertiary referral centres. A total of 172 patients who underwent combined resection for locally advanced primary rectal cancer were classified based on four subtypes (PPE-I [64/172], PPE-II [68/172], PPE-III [21/172], and PPE-IV [19/172]) according to the Peking classification; perioperative characteristics and short-term and oncological outcomes were analysed.

Results
Differences were significant among the four groups regarding colorectal reconstruction (p < 0.001), perineal reconstruction (p < 0.001), in-hospital complications (p < 0.05), and urinary retention (p < 0.05). The R0 resection rates for PPE-I, PPE-II, PPE-III, and PPE-IV were 90.6%, 89.7%, 90.5%, and 89.5%, respectively. The 5-year overall survival rates of the PPE-I, PPE-II, PPE-III, and PPE-IV groups were 73.4%, 68.8%, 54.7%, and 37.3%, respectively. Correspondingly, their 5-year disease-free survival rates were 76.0%, 62.5%, 57.7%, and 43.1%, respectively. Notably, the PPE-IV group demonstrated the lowest 5-year overall survival rate (p < 0.001) and 5-year disease-free survival rate (p < 0.001).

Conclusion
The Peking classification can aid in determining suitable surgical techniques and conducting prognostic assessments in female patients with locally advanced primary rectal cancer.
“Expression of concern”: publication bias for positive preclinical cardioprotection studies
Authors: Skyschally Andreas , Kleinbongard Petra , Neuhäuser Markus , Heusch Gerd 
Published: April 2024

AbstractThe present analysis reports on the robustness of preclinical cardioprotection studies with infarct size as endpoint which were published in Basic Research in Cardiology, Cardiovascular Research, and Circulation Research between January 2013 and December 2023. Only 26 out of 269 papers with technically robust analysis of infarct size by triphenyltetrazolium chloride staining, magnetic resonance imaging or single photon emission tomography applied a prospective power analysis. A retrospective power calculation revealed that only 75% of the reported data sets with statistically significant positive results from all these studies had a statistical power of  ≥ 0.9, and an additional 9% had a statistical power  ≥ 0.8. The remaining 16% of all significant positive data sets did not even reach the 0.8 threshold. Only 13% of all analyzed data sets were neutral. We conclude that neutral studies are underreported and there is indeed a significant lack of robustness in many of the published preclinical cardioprotection studies which may contribute to the difficulties of translating cardioprotection to patient benefit.
Sudden unexpected postnatal collapse and BUB1B mutation: first forensic case report
Authors: Esposito Massimiliano , Sessa Francesco , Nannola Chiara , Pignotti Maria Serenella , Greco Pantaleo , Salerno Monica 
Published: April 2024

AbstractSudden unexpected postnatal collapse (SUPC) is a sudden collapse of the clinical conditions of a full-term or near-term newborn, within the first 7 days of life, that requires resuscitation with positive ventilation and who either dies, has hypoxic-ischemic encephalopathy, or requires intensive care. The incidence of SUPC is very low, and most often presents a negative prognosis. The BUB1B gene is a mitotic checkpoint of serine/threonine kinase B that encodes a protein crucial for maintaining the correct number of chromosomes during cell division. Mutations in the BUB1B gene are linked to mosaic variegated aneuploidy syndrome 1 (MVA1), a rare autosomal recessive disorder characterized by diffuse mosaic aneuploidies involving several chromosomes and tissues. This paper discusses a case of a newborn who had a spontaneous delivery. After 2 h and 10 min, the infant showed generalized hypotonia and cyanosis, and his doctors performed orotracheal intubation, cardiac massage, pharmacological hemodynamic therapy, mechanical ventilation, antibiotic therapy, and hypothermic treatment. The newborn was discharged after 5 months with the diagnosis of hypoxic-ischemic encephalopathy. Suspecting an SUPC, a complete genetic analysis was performed demonstrating a compound heterozygous mutations in the BUB1B gene. The newborn died at 6 months of life, 1 month after discharge. A complete autopsy was performed, determining that the cause of death was due to sepsis starting from a brocopneumonic process, with outcomes of hypoxic-ischemic encephalopathy (HIE). In this scenario, it is not possible to demonstrate the causal effect of this mutation, considering that it could play a causal or concausal role in the onset of SUPC. Further research based on multicenter studies, as well as on animal models, could be very useful to clarify the pathological effect of this mutation.
Examination of cardiac functions during acute attack and remission period in children with familial Mediterranean fever
Authors: Gunay Yusuf , Karagozlu Fatih , Gemici Sanem , Yilmaz Seyma Sukran , Sahin Sezgin , Barut Kenan , Kasapcopur Ozgur , Dedeoglu Reyhan 
Published: April 2024

AbstractFamilial Mediterranean fever (FMF) is an autosomal recessive autoinflammatory disease characterized by recurring serosal inflammation. Cardiac involvement in FMF commonly manifests as pericarditis and pericardial effusion; however, there is limited research on myocardial function. This study aimed to assess cardiac functions during active inflammation and remission periods of FMF patients and investigate the cardiac effects of inflammation during the attack period. Thirty-eight FMF patients without additional cardiac diseases were included in the study. Demographic characteristics, clinical symptoms, family history, and MEFV gene analysis results were obtained retrospectively. Blood tests, blood pressure measurements, electrocardiogram evaluations, conventional echocardiography, and speckle tracking echocardiography were performed during the attack and remission periods. Disease severity was assessed using the Pras scoring system. During the attack period, FMF patients exhibited significantly higher leukocyte count, neutrophil count, C-reactive protein, and erythrocyte sedimentation rate compared to the remission period (p < 0.005). Speckle tracking echocardiography revealed decreased function in the inferior segments of the left ventricle during the attack period (p < 0.005). Right ventricular function was more affected in the moderate disease group. FMF patients with lymphopenia during the attack demonstrated more impaired right ventricular function compared to those with normal lymphocyte count.  Conclusions: FMF patients experience cardiac abnormalities during active inflammation, highlighting the importance of monitoring cardiac functions in these patients. Speckle tracking echocardiography can provide valuable insights into cardiac involvement in FMF. These findings emphasize the cardiac impact of FMF inflammation and the significance of long-term cardiac function monitoring in the management of FMF patients.

What is Known:• The current literature lacks studies investigating myocardial function in the pediatric population during the attack period of this particular disease.• Our objective was to assess the alterations in cardiac function during the attack and remission periods, considering clinical manifestations, disease severity, acute phase reactant levels, and mutation type. We also evaluated the pattern of cardiac involvement and the affected cardiac areas by comparing remission and attack periods.

What is New:• Several studies have demonstrated a rise in the prevalence of ischemic cardiac disease and mortality among individuals with FMF.• Investigating cardiac involvement during the attack period in FMF patients can provide valuable insights for the prevention of long-term complications.
PINN-CHK: physics-informed neural network for high-fidelity prediction of early-age cement hydration kinetics
Authors: Rahman Md Asif , Zhang Tianjie , Lu Yang 
Published: April 2024

AbstractCement hydration kinetics, characterized by heat generation in early-age concrete, poses a modeling challenge. This work proposes a physics-informed neural network (PINN) named PINN-CHK designed for cement hydration kinetics, to predict early-age temperature rises in cement paste. PINN-CHK leverages data-driven solutions to craft a high-fidelity prediction model, encompassing material properties and maturity functions in cement hydration. Trained on heated cement paste data, it simultaneously fits experimental results and underlying physics, yielding a mesh-free simulation. Incorporating governing partial differential equations (PDEs), and initial and boundary conditions into its loss function, PINN-CHK architecture undergoes rigorous benchmark testing, demonstrating unparalleled predictive accuracy compared to conventional deep-learning methods. It excels in predicting complete temperature fields during spatial–temporal cement hydration, achieving a remarkable relative L2 error as low as 0.00341. PINN-CHK achieves exceptional convergence and accuracy with only 5% of the training data, ushering in a new era in this crucial field. This innovative approach bridges the gap between theory and practice, offering an attractive alternative to conventional finite element solvers for enhanced comprehension of cement hydration kinetics and concrete maturity and strength development in cement-based materials.
Traveling waves and effective mass for the regularized Landau-Pekar equations
Authors: Rademacher Simone 
Published: April 2024

AbstractWe consider the regularized Landau-Pekar equations with positive speed of sound and prove the existence of subsonic traveling waves. We provide a definition of the effective mass for the regularized Landau-Pekar equations based on the energy-velocity expansion of subsonic traveling waves. Moreover we show that this definition of the effective mass agrees with the definition based on an energy-momentum expansion of low energy states.
Vom Zusammenhang zwischen bariatrischer Chirurgie und Vitaminen
Authors: Rockenschaub Joachim , Listabarth Stephan , Weber Sabine , Wippel Andreas , Friedrich Fabian , Mossaheb Nilufar 
Published: April 2024

ZusammenfassungBei unklaren neuropsychiatrischen Symptomen ist neben profunder Kenntnis über mögliche Ursachen eine zielgerichtete organische Abklärung ausschlaggebend. Richtungsweisend können hierbei eine umfassende Anamneseerhebung sowie interdisziplinäres Management sein. Der diagnostische Prozess soll im Zuge dieser Arbeit anhand des konkreten Beispiels von Wernicke-Enzephalopathie (WE) durch Hypovitaminose nach bariatrischer Operation aufgezeigt werden. In Hinblick auf steigende Inzidenzen von Eingriffen werden WE zunehmend häufiger zu beobachten sein und sind aufgrund der schwerwiegenden neurologischen Komplikationen von zentraler Bedeutung. Neben ausführlicher Eigen- und Außenanamnese sowie neurologischer und internistischer Statuierung sind konsiliarische Unterstützung, Bildgebung und Laboruntersuchungen erforderlich. Im Falle der WE haben neben den Caine-Kriterien, welche Mangelernährung, okulomotorische Anomalien, zerebelläre Dysfunktionen oder Wesensveränderungen/Gedächtnisstörungen (mind. 2 von 4 Kriterien vorliegend) inkludieren, auch die kranialen Magnetresonanzuntersuchungen diagnostischen Wert. Eine frühzeitige Gabe von Thiamin ist entscheidend für die Behandlung und Prävention sowie Langzeitschäden von WE.
Peri-implantitis in patients without regular supportive therapy: Prevalence and risk indicators
Authors: Ruiz-Romero Víctor , Figueiredo Rui , Toledano-Serrabona Jorge , Abdelazim Yehia , Camps-Font Octavi , Salazar-Salazar Yamil , Plana-Soler Aina , Subirà-Pifarré Carles , Valmaseda-Castellón Eduard 
Published: April 2024

Abstract
Objectives
To determine the prevalence of peri-implant diseases in patients treated in a university setting without a regular peri-implant supportive therapy schedule, and to identify the risk indicators associated with peri-implantitis.

Material and methods
A retrospective cohort study was made of patients with dental implants with at least 12 months of functional loading who did not receive regular peri-implant supportive therapy. Patient- and implant-related variables were retrieved, and clinical and radiological examinations were performed. Descriptive and bivariate analyses and multilevel logistic regression analyses were performed to identify factors associated with peri-implantitis.

Results
A total of 213 implants in 88 patients were analyzed. The patient-level prevalence of peri-implantitis and peri-implant mucositis was 26.1% (95%CI: 16.7%—35.5%) and 44.3% (95%CI: 34.0%—54.6%), respectively. Peri-implant diseases were significantly more frequent when the width of the keratinized mucosa was < 2 mm (OR = 5.26; 95%CI: 1.24—22.26; p = 0.024), and when there was 12 month post-loading bone loss (OR = 2.96; 95%CI: 1.35—6.52; p = 0.007).

Conclusions
Peri-implantitis is a common finding in patients without regular peri-implant supportive therapy (prevalence 16.7–35.5%). A thin peri-implant keratinized mucosa (< 2 mm) and a higher degree of bone remodeling after loading seem to be the main risk factors for peri-implantitis in this patient profile.

Clinical relevance
Patients who do not engage in supportive peri-implant maintenance have a higher risk of peri-implantitis. A thin keratinized mucosa and bone loss during the first year of loading are predisposing factors for peri-implantitis.
Robustness verification of k-nearest neighbors by abstract interpretation
Authors: Fassina Nicolò , Ranzato Francesco , Zanella Marco 
Published: April 2024

AbstractWe study the certification of stability properties, such as robustness and individual fairness, of the k-nearest neighbor algorithm (kNN). Our approach leverages abstract interpretation, a well-established program analysis technique that has been proven successful in verifying several machine learning algorithms, notably, neural networks, decision trees, and support vector machines. In this work, we put forward an abstract interpretation-based framework for designing a sound approximate version of the kNN algorithm, which is instantiated to the interval and zonotope abstractions for approximating the range of numerical features. We show how this abstraction-based method can be used for stability, robustness, and individual fairness certification of kNN. Our certification technique has been implemented and experimentally evaluated on several benchmark datasets. These experimental results show that our tool can formally prove the stability of kNN classifiers in a precise and efficient way, thus expanding the range of machine learning models amenable to robustness certification.
Revisiting the use of the EORTC QLQ-STO22 to assess health-related quality of life of patients with gastric cancer: incorporating updated treatment options and cross-cultural perspectives
Authors: Sodergren S. C. , Hurley-Wallace A. , Vassiliou V. , Alkhaffaf B. , Batsaikhan B. , Darlington A. S. , Fleitas-Kanonnikof T. , Guren M. G. , Honda M. , Kim Y. W. , Kim S. , Krishnamurthy M. N. , Loh S. Y. , Turhal N. S. , Zhou J. , Dennis K. , Krishnatry R. , Terashima M. , Tsironis G. , Yoshikawa T. , Terada M. ,   On behalf of the EORTC Quality of Life Group, Georgiou Loukia , Harvey Alice , Hikage Makoto , Hirano Hidekazu , Iglesias Loli , Ishiki Hiroto , Lau Peng Choong , Lopez Beatriz , Papageorgiou Elisavet , Rees Charlotte , Rowsell Alison , Stylianou Ioannis , Wada Takeyuki , Wedge Elizabeth , Wong Wei Jin 
Published: April 2024

Abstract
Background
The EORTC QLQ-STO22 (QLQ-STO22) is a firmly established and validated measure of health-related quality of life (HRQoL) for people with gastric cancer (GC), developed over two decades ago. Since then there have been dramatic changes in treatment options for GC. Also, East Asian patients were not involved in the development of QLQ-STO22, where GC is most prevalent and the QLQ-STO22 is widely used. A review with appropriate updating of the measure was planned. This study aims to capture HRQoL issues associated with new treatments and the perspectives of patients and health care professionals (HCPs) from different cultural backgrounds, including East Asia.

Methods
A systematic literature review and open-ended interviews were preformed to identify potential new HRQoL issues relating to GC. This was followed by structured interviews where HCPs and patients reviewed the QLQ-STO22 alongside new issues regarding relevance, importance, and acceptability.

Results
The review of 267 publications and interviews with 104 patients and 18 HCPs (48 and 9 from East Asia, respectively) generated a list of 58 new issues. Three of these relating to eating small amounts, flatulence, and neuropathy were recommended for inclusion in an updated version of the QLQ-STO22 and covered by five additional questions.

Conclusions
This study supports the content validity of the QLQ-STO22, suggesting its continued relevance to patients with GC, including those from East Asia. The updated version with additional questions and linguistic changes will enhance its specificity, but further testing is required.