bluuebunny/crossref_metadata_2025_split huggingface dataset:
The role of Patient and public involvement (PPI) in pre-clinical spinal cord research: An interview study
Authors: Carroll Pádraig , Dervan Adrian , McCarthy Ciarán , Woods Ian , Beirne Cliff , Harte Geoff , O’Flynn Dónal , O’Connor Cian , McGuire Tara , Leahy Liam M. , Gonzalez Javier Gutierrez , Stasiewicz Martyna , Maughan Jack , Quinlan John , Smith Éimear , Moriarty Frank , O’Brien Fergal J. , Flood Michelle 
Published: April 2024

Background
Patient and public involvement in research (PPI) has many benefits including increasing relevance and impact. While using PPI in clinical research is now an established practice, the involvement of patients and the public in pre-clinical research, which takes place in a laboratory setting, has been less frequently described and presents specific challenges. This study aimed to explore the perspectives of seriously injured rugby players’ who live with a spinal cord injury on PPI in pre-clinical research.

Methods
Semi-structured interviews were conducted via telephone with 11 seriously injured rugby players living with spinal cord injury on the island of Ireland. A purposive sampling approach was used to identify participants. Selected individuals were invited to take part via gatekeeper in a charitable organisation that supports seriously injured rugby players. Interviews were transcribed verbatim and analysed thematically.

Findings
Six themes were identified during analysis: ‘appreciating potential benefits of PPI despite limited knowledge’, ‘the informed perspectives of people living with spinal cord injury can improve pre-clinical research relevance’, ‘making pre-clinical research more accessible reduces the potential for misunderstandings to occur’, ‘barriers to involvement include disinterest, accessibility issues, and fear of losing hope if results are negative’, ‘personal contact and dialogue helps people feel valued in pre-clinical research, and ‘PPI can facilitate effective dissemination of pre-clinical research as desired by people living with spinal cord injury.’

Conclusion
People affected by spinal cord injury in this study desire further involvement in pre-clinical spinal cord injury research through dialogue and contact with researchers. Sharing experiences of spinal cord injury can form the basis of PPI for pre-clinical spinal cord injury research.
The cross-sectional association of parental psychosocial status with children’s Body Mass Index z-score and the mediating role of children’s energy balance behaviors - the ABCD Study
Authors: Overman Meredith L. , Vrijkotte Tanja , Sánchez Castro Yolanda M. , Harskamp-van Ginkel Margreet W. , Hunsberger Monica , Renders Carry M. , Kremers Stef P. J. , Chinapaw Mai J. M. 
Published: April 2024

Objective
Investigate the cross-sectional association between the psychosocial status of mothers and fathers and the BMI z-scores of their 10 to 12-year-old children. Explore whether this association is mediated by children’s diet, physical activity, screen time and sleep. Analyze the moderating effect of the educational levels of both the mother and father on the association.

Design
In a cross-sectional study design, children’s height and weight were measured following a standardized protocol. Parents completed the validated Depression Anxiety and Stress questionnaire, while diet quality, sports participation, time spent in bed and screen time were assessed through child-report using previously validated questions.

Participants
The data for this study were obtained from the Amsterdam Born Children and their Development study, involving children aged 10 to 12 years and both of their parents (N = 1315).

Results
The majority, 80%, of the parents were highly educated and born in the Netherlands, and 68% of the children had a healthy BMI. Maternal or paternal psychosocial status was not significantly associated with children’s BMI z-score (maternal β -0.0037; 95% CI: -0.008 to 0.0007, paternal β 0.0028; 95% CI: -0.007 to 0.002). Screen time mediated the association between paternal psychosocial status and children’s BMI z-score (β = 0.010, 95% CI: 0.002; 0.020). Children’s diet, physical activity, and sleep did not mediate the association between paternal psychosocial status and children’s BMI z-score. Parental educational level was not a moderator.

Conclusions
This research is unique in including four energy balance behaviors and including both mothers and fathers’ psychosocial status. Children withfathers experiencing poorer psychosocial status engaged in more screen time which partly explained their higher BMI z-score.
Insights about the deleterious impact of a carbamate pesticide on some metabolic immune and antioxidant functions and a focus on the protective ability of a Saharan shrub and its anti-edematous property
Authors: Khattabi Latifa , Khaldi Taha , Bahri Laid , Mokhtari Mohamed Badreddine , Bouhenna Mustapha Mounir , Temime Asma , Boural Hasna , Bouhedjar Khalid , Hemida Houari , Atoki Ayomide Victor , Messaoudi Mohammed 
Published: April 2024

Abstract
In the Algerian desert, individuals often enjoy a soothing cup of herbal tea made from Ephedra alata Decne before bedtime; this aids in their relaxation. Our previous and earlier investigations demonstrated the richness of the shrub in terms of polyphenols and flavonoids and their effective medicinal properties. In the light of that fact, our interest has been aroused to check for other types of metabolites and for the protective ability of the shrub crude extract (SCE) regarding chemically induced edema and subacute toxicity (following a formalin-induced paw edema model and using a carbamate pesticide “pirimicarb” as a toxic agent, in Wistar male rats, respectively). Evidently, the SCE was used as a preventive agent. Swelling of formalin-injected foot was measured, and the anti-edematous ability was expressed as a percent of paw edema. At the end of induced subacute toxicity procedure, many investigations were carried, namely, checking for biochemical several parameters (hepatic, renal), hematological parameters, oxidative stress status (OSS), and histological examining of liver, spleen, and kidney tissues. The results revealed a remarkable anti-edematous effect. Furthermore, the association of the SCE effect has clearly minimized the OSS, the tissue aberrations, and the disturbance of the other metabolic parameters, along with a reduced immunodepression that was provoked under the effect of pirimicarb. In conclusion, pirimicarb has an important deleterious impact on metabolic and immune functions, and the studied shrub has exhibited an amazing protective potential against chemically induced inflammation and toxicity.
‘Seeking Justice, Not Charity’. Medical Experiment Victims’ Struggle with Purposefully Inadequate Compensation
Authors: Weinberger Ruth Jolanda 
Published: April 2024

Abstract
Germany’s initial Wiedergutmachung process did little good for survivors of Nazi medical experiments who struggled with uniquely devastating circumstances. Unable to navigate the nascent post-war compensation bureaucracy, many were left with shockingly little financial assistance, or none at all. That was even the case for one of the victims, Haim Nahon, who had the leadership of the primary restitution agency personally fighting on his behalf. Despite the focus of the Conference on Jewish Material Claims Against Germany on communal relief and rehabilitation and not on individual compensation, Nahon’s plight was taken up by Benjamin Ferencz, Saul Kagan and other senior figures involved in Wiedergutmachung. Yet even their direct involvement in early compensation efforts, documented in this article in granular first-person accounts, could do little to help Nahon’s case. Nahon’s failed attempts to obtain “adequate” post-war compensation from Germany’s Ministry of Finance offer an unsettling case study of how willfully limited interpretations of the initial 1951 restitution fund had a lifelong cost for survivors of Nazi medical experiments.
Intrapartum pyrexia, cardiotocography traces and histologic chorioamnionitis: a case-control study
Authors: Barbieri Sara , Fichera Anna , Orabona Rossana , Fratelli Nicola , Odicino Franco E. , Prefumo Federico 
Published: April 2024

Abstract

Objectives
To compare characteristics of labor, cardiotocography traces, and maternal and neonatal outcomes, in a cohort of pregnancies at term complicated by maternal intrapartum pyrexia, with or without a histologic diagnosis of chorioamnionitis.

Methods
This is a retrospective case-control study including pregnancies at term with detection of maternal intrapartum pyrexia, delivered between January 2020 and June 2021. Cardiotocography traces were entirely evaluated, since admission till delivery, and classified according to the International Federation of Obstetrics and Gynecology (FIGO) guideline. Maternal and neonatal outcomes were also recorded as secondary outcomes. Placentas have been studied according to the Amniotic Fluid Infection Nosology Committee.

Results
Forty four patients met the inclusion criteria and were included in the study cohort. There was a significant association between the use of oxytocin augmentation in labor and the histologic diagnosis of chorioamnionitis. A significative recurrence of loss and/or absence of accelerations at the point of pyrexia was also documented in women with histological chorioamnionitis compared to the others.

Conclusions
Chorioamnionitis appears to be associated with myometrial disfunction, as suggested by the increased use of oxytocin augmentation during active labor of women at term with intrapartum pyrexia and histologic diagnosis of chorioamnionitis.
Placeholders in crosslinguistic perspective: abilities, preferences, and usage motives
Authors: Seraku Tohru 
Published: April 2024

Abstract
In spontaneous discourse, a speaker sometimes encounters word-formulation trouble, and she may use a ‘placeholder’ (PH) such as whatchamacallit and you-know-what, a dummy expression to be inserted into the slot of a ‘target form’ in the sentence structure of an utterance. It has been widely held that there are two types of usage motives: (i) a speaker cannot produce a target form when, e.g., she does not recall it, or (ii) a speaker does not want to produce a target form when, e.g., it is considered taboo. Previous studies have described the grammatical and functional properties of PHs in a variety of languages, but no study has examined their usage-motive patterns crosslinguistically. In this paper, I propose an implicational hierarchy relating to the usage motives of PHs based on the relevance-theoretic notions of ‘ability’ and ‘preference’ and derive several predictions from this hierarchy, which are tested against PH data in 56 languages. The predictions are mostly confirmed, with some (putative) counterexamples explained by non-cognitive–pragmatic factors (e.g., lexical-semantic factors). As an implication, the hierarchy may also serve as a basis for drawing predictions in other linguistic fields (e.g., language acquisition).
Ideological framing of sign languages and their users in the South African press
Authors: Carne Carmel , Oostendorp Marcelyn , Baker Anne 
Published: April 2024

Abstract
This exploratory study provides an overview of prominent themes pertaining to portrayals of sign languages (SLs) and Deaf people in the South African press (2011–2019), as well as an analysis of a subset of articles to illustrate the discursive constructions of each of the prominent ideological framings. The findings of the paper suggest that many ways of representing South African Sign Language (SASL) and their users align with international trends. The two most prominent ideological framings are the medical/disability model and the linguistic minority model. Within the medical model, SLs are seen as inferior means of communication used by a disabled minority. Within the linguistic minority framework SLs are regarded as natural, legitimate languages deserving equal status to spoken languages. The paper also identifies an ideological framing that is not predicted by the international literature, coined here as ‘diversity tokenism’. Diversity tokenism is when SL is mentioned only to increase perceived diversity, where diversity is a commodity that holds social capital. This portrayal of SASL seems to be increasing and holds a warning: although SASL users have received official recognition and rights through the recent declaration of SASL as an official language, it might not be the end of the battle to ensure that users of SASL can live out their linguistic citizenship.
Impact of carbon content on the phase structure and mechanical properties of TiBCN coatings via direct current magnetron sputtering
Authors: Vyas Anand , Aliyu Ahmed , Tsui Gary Chi-Pong 
Published: April 2024

Abstract
In this study, unbalanced direct current magnetron sputtering was employed to develop TiBCN coatings on Si (100) wafers. The carbon (C) concentration was varied to manipulate the phase structure and mechanical properties of the coatings. The coatings were analyzed using Raman spectroscopy, scanning electron microscopy, X-ray diffraction, X-ray photoelectron spectroscopy, and nanoindentation. The results revealed that the TiBCN-2 coating, with a C concentration of 4.4 at.%, exhibited optimal hardness and elastic modulus values of 33 and 291 GPa, respectively. On the other hand, as the C content increased from 4.4 to 24.4 at.%, the hardness and elastic modulus values of the coatings decreased to 21 and 225 GPa, respectively, due to the formation of boron nitride and carbon phases within the coating matrix. Therefore, the inclusion of an ideal C concentration can considerably improve the properties of TiBCN coatings, thus rendering the coating a desirable material for cutting tools.
Social determinants of health in adults with whiplash associated disorders
Authors: Jasper Lisa , Smith Ashley D. 
Published: April 2024

Abstract

Objectives
Although it is well-known that chronic diseases need to be managed within the complex biopsychosocial framework, little is known about the role of sociodemographic features in adults with whiplash-associated disorders (WAD) and their association with health outcomes. The aim of this study was to investigate the association between various sociodemographic features (age, sex, ethnicity, education, working, marriage, caring for dependents, and use of alcohol and drugs) and health outcomes (pain, disability, and physical/mental health-related quality of life) in WAD, both through their individual relationships and also via cluster analysis.

Methods
Independent t-tests and Kruskal–Wallis tests (with Mann–Whitney tests where appropriate) were used to compare data for each health outcome. Variables demonstrating a significant relationship with health outcomes were then entered into two-step cluster analysis.

Results

N = 281 participated in study (184 females, mean (±SD) age 40.9 (±10.7) years). Individually, level of education (p = 0.044), consumption of non-prescribed controlled or illegal drugs (p = 0.015), and use of alcohol (p = 0.008) influenced level of disability. Age (p = 0.014), marriage status (p = 0.008), and caring for dependents (p = 0.036) influenced mental health quality of life. Collectively, two primary clusters emerged, with one cluster defined by marriage, care of dependents, working status, and age >40 years associated with improved mental health outcomes (F
1,265 = 10.1, p = 0.002).

Discussion
Consistent with the biopsychosocial framework of health, this study demonstrated that various sociodemographic features are associated with health outcomes in WAD, both individually and collectively. Recognizing factors that are associated with poor health outcomes may facilitate positive outcomes and allow resource utilization to be tailored appropriately.
A mini review on the applications of artificial intelligence (AI) in surface chemistry and catalysis
Authors: Al-Akayleh Faisal , Ali Agha Ahmed S. A. , Abdel Rahem Rami A. , Al-Remawi Mayyas 
Published: April 2024

Abstract
This review critically analyzes the incorporation of artificial intelligence (AI) in surface chemistry and catalysis to emphasize the revolutionary impact of AI techniques in this field. The current review examines various studies that using AI techniques, including machine learning (ML), deep learning (DL), and neural networks (NNs), in surface chemistry and catalysis. It reviews the literature on the application of AI models in predicting adsorption behaviours, analyzing spectroscopic data, and improving catalyst screening processes. It combines both theoretical and empirical studies to provide a comprehensive synthesis of the findings. It demonstrates that AI applications have made remarkable progress in predicting the properties of nanostructured catalysts, discovering new materials for energy conversion, and developing efficient bimetallic catalysts for CO2 reduction. AI-based analyses, particularly using advanced NNs, have provided significant insights into the mechanisms and dynamics of catalytic reactions. It will be shown that AI plays a crucial role in surface chemistry and catalysis by significantly accelerating discovery and enhancing process optimization, resulting in enhanced efficiency and selectivity. This mini-review highlights the challenges of data quality, model interpretability, scalability, and ethical, and environmental concerns in AI-driven research. It highlights the importance of continued methodological advancements and responsible implementation of artificial intelligence in catalysis research.
Investigations on the microbial activity and anti-corrosive efficiency of nickel oxide nanoparticles synthesised through green route
Authors: Mohamed Kasim Sheit Hameed , Seeni Mubarak Mohamed U. , Mohan Konganapuram S. , Gunavathy Kugalur V. , Subhapriya Pushparaju , Varusai Mohamed Mohamed K. 
Published: April 2024

Abstract
Researchers have shown considerable interest in the environmentally friendly synthesis of several nanoparticles particularly metal nano particles due to their multifaceted applications. The target of the current research includes the synthesis of nickel oxide nanoparticles (NiO-NPs) through the green route using the bark extract from Acacia Nilotica, and analyzed their chemical and surface morphological features using XRD, SEM, EDX, IR, UV–vis and photoluminescence spectroscopy. In addition, the corrosion inhibition ability and antimicrobial activity of the extract were also studied. The XRD analysis indicated that the NiO exist in the form of nanoparticles. It showed the formation of pure cubic NiO-NP with a prominent peak at 43.28° reflected from the plane (200). The crystallite size was found to be 15.83 nm. The SEM micrographs revealed that NiO-NPs appeared to be a bulk cluster-like structure on their surface.The EDX analysis displayed the presence of Ni and oxygen atoms. The photoluminescence spectrum demonstrated that the green synthesized metal oxide nanoparticles have a modified emission band due to the presence of oxygen deficiencies and induced surface imperfections. The Fourier transform infrared spectroscopy (FTIR) confirmed the association of peaks with the C–H and Ni–O bonds. The UV–vis study showed a maximum absorption at 264 nm. A study on the inhibition efficiency towards microbes confirmed that the prepared NiO-NPs have a good inhibition against selected microbes such as S. aureus, E. coli, Candida albicans, A. Niger. The mass loss system showed restraint 93.68 % effectiveness in the mild steel, and the electrochemical study supported the formation of a defensive protective layer on the cathodic locales of the carbon steel surface inhibiting corrosion.
Changes in metabolic hormones and trace elements in CSF in active smokers indicate oxidative damage to brain cells
Authors: Zheng Peiwen , Wang Fan , Li Hui , Chen Hanlu , Li Mengtong , Ma Haozheng , He Jue , Chen Li , Liu Yanlong , Xu Haiyun 
Published: April 2024

Objective
This study aimed to reveal associations between metabolic hormones in cerebral spinal fluid (CSF) and cigarette smoking-induced weight gain and to explore the underlying mechanism.

Methods
A total of 156 adult men were included, comprising active smokers and nonsmokers. In addition to demographic information and body mass index (BMI), plasma levels of ApoA1 and ApoB, high-density lipoprotein, low-density lipoprotein, cholesterol, triglyceride, alanine aminotransferase, aspartate aminotransferase, and gamma-glutamyl transferase in the participants were measured. Moreover, the metabolic hormones adiponectin, fibroblast growth factor 21 (FGF21), ghrelin, leptin, and orexin A, as well as the trace elements iron and zinc in CSF, were assessed.

Results
Compared to nonsmokers, active smokers showed higher BMI, and elevated CSF levels of FGF21, Zn, and Fe, but decreased levels of metabolic hormones adiponectin, ghrelin, leptin, and orexin A. Negative correlations existed between CSF FGF21 and ghrelin, between CSF Zn and ghrelin, as well as between CSF Fe and orexin A in active smokers. Furthermore, elevated CSF FGF21 and Zn predicted ghrelin level decrease in the smokers.

Conclusion
These data relate smoking-induced weight gain to its neurotoxic effect on the neurons that synthesize metabolic hormones such as adiponectin, ghrelin, leptin, or orexin A in the brain, by disrupting mitochondrial function and causing oxidative stress in the neurons.
Thyroid autoimmunity in euthyroid pregnant women is associated with slower productive language acquisition: the Odense child cohort study
Authors: Riis Kamilla R , Bonnema Steen J , Dreyer Anja F , Glintborg Dorte , Bilenberg Niels , Bleses Dorthe , Trecca Fabio , Andersen Marianne S 
Published: April 2024

Objective
Maternal thyroid autoimmunity and thyroid function in early pregnancy may impact fetal neurodevelopment. We aimed to investigate how thyroid autoimmunity and thyroid function in early pregnancy were associated with language acquisition in offspring at 12–36 months of age.

Methods
This study was embedded in the prospective Odense child cohort. Mother–child dyads were excluded in case of maternal intake of thyroid medication during pregnancy. The parents completed MacArthur–Bates Communicative Development Inventories (MB-CDI) every third month to assess their offspring’s productive vocabulary. All completed reports for each child were included in the analyses. Logistic growth curve models evaluated associations between MB-CDI scores and levels of maternal thyroid peroxidase antibodies (TPOAb), free thyroxine (FT4), and thyrotropin, respectively, measured in early pregnancy (median gestational week 12). All models were stratified by offspring sex and adjusted for maternal age, education, pre-pregnancy body mass index, parity, breastfeeding, and offspring age.

Results
The study included 735 mother–child dyads. Children born to mothers with TPOAb ≥11 kIU/L, opposed to TPOAb <11 kIU/L, had a lower probability of producing words at age 18–36 months for girls (OR = 0.78, P < 0.001) and 33–36 months for boys (OR = 0.83, P < 0.001). The probability of producing words was higher in girls at 30–36 months of age with low-normal maternal FT4 vs high-normal FT4 (OR = 0.60, P < 0.001), and a similar trend was seen in boys. Results were ambiguous for thyrotropin.

Conclusion
In women without known thyroid disease, TPOAb positivity in early pregnancy was negatively associated with productive vocabulary acquisition in girls and boys. This association was not mediated by a decreased thyroid function, as low-normal maternal FT4, unexpectedly, indicated better vocabulary acquisition. Our results support that maternal thyroid autoimmunity per se may affect fetal neurodevelopment.