bluuebunny/crossref_metadata_2025_split huggingface dataset:
Tripled likelihood: polypharmacy increases the occurrence of drug therapy problems in hospitalized pediatric patients
Authors: Takele Bereket , Koyra Hailu Chare , Sidamo Temesgen , Lerango Temesgen Leka 
Published: April 2024

BackgroundA drug therapy problem (DTP) is any undesirable event experienced by a patient that accompanies drug therapy, prevents the patient from achieving their desired therapeutic goals, and requires expert judgment to resolve. Pediatric populations are at a higher risk of DTP than adults due to their immature organ systems, including the liver and kidneys, which play crucial roles in drug metabolism and excretion. Most previous studies have focused on only one element of DTP. Therefore, by considering all elements of DTP, we aimed to assess the prevalence of DTP and associated factors among pediatric patients admitted to the Wolaita Sodo University Comprehensive Specialized Hospital.MethodsAn institution-based cross-sectional study was conducted among pediatric patients admitted to Wolaita Sodo University Comprehensive Specialized Hospital from 8 July 2020, to 7 July 2021. A simple random sampling technique was employed to select study participants. Cipolle’s and Strand’s classification method of drug therapy problems was used to identify and categorize DTP. Data were obtained by reviewing the patient’s medical records using a data abstraction checklist, entered into Epi data version 4.6, and exported to SPSS version 25 for analysis. Binary logistic regression analysis was performed to identify independent predictors of DTP.ResultsMedical records of 369 pediatric patients were reviewed, and the overall prevalence of DTP was 60.2% (95% CI:55.2%, 65.2%) with a total of 281 identified DTPs. Among them, 164 (74.2%) had only one DTP. Need additional drug therapy was the most common (140 [49.8%]) DTP identified. The number of disease conditions (AOR = 2.13, 95% CI:1.16, 3.92), polypharmacy (AOR = 3.01, 95% CI:1.70, 5.32), and duration of hospital stay (AOR = 1.80, 95% CI:1.04, 3.10) were independent predictors of DTP among admitted pediatric patients.ConclusionThe prevalence of DTP in pediatric patients in the current setting was high. The number of disease conditions, polypharmacy, and duration of hospital stay were independent predictors of DTP. Enhancements to pharmaceutical care services, optimized dosage practices, improved deprescribing by clinicians, and efficient, comprehensive diagnostic procedures have the potential to significantly reduce specific drug therapy problems in hospitalized pediatrics.
Automatic grading evaluation of winter wheat lodging based on deep learning
Authors: Zang Hecang , Su Xinqi , Wang Yanjing , Li Guoqiang , Zhang Jie , Zheng Guoqing , Hu Weiguo , Shen Hualei 
Published: April 2024

Lodging is a crucial factor that limits wheat yield and quality in wheat breeding. Therefore, accurate and timely determination of winter wheat lodging grading is of great practical importance for agricultural insurance companies to assess agricultural losses and good seed selection. However, using artificial fields to investigate the inclination angle and lodging area of winter wheat lodging in actual production is time-consuming, laborious, subjective, and unreliable in measuring results. This study addresses these issues by designing a classification-semantic segmentation multitasking neural network model MLP_U-Net, which can accurately estimate the inclination angle and lodging area of winter wheat lodging. This model can also comprehensively, qualitatively, and quantitatively evaluate the grading of winter wheat lodging. The model is based on U-Net architecture and improves the shift MLP module structure to achieve network refinement and segmentation for complex tasks. The model utilizes a common encoder to enhance its robustness, improve classification accuracy, and strengthen the segmentation network, considering the correlation between lodging degree and lodging area parameters. This study used 82 winter wheat varieties sourced from the regional experiment of national winter wheat in the Huang-Huai-Hai southern area of the water land group at the Henan Modern Agriculture Research and Development Base. The base is located in Xinxiang City, Henan Province. Winter wheat lodging images were collected using the unmanned aerial vehicle (UAV) remote sensing platform. Based on these images, winter wheat lodging datasets were created using different time sequences and different UAV flight heights. These datasets aid in segmenting and classifying winter wheat lodging degrees and areas. The results show that MLP_U-Net has demonstrated superior detection performance in a small sample dataset. The accuracies of winter wheat lodging degree and lodging area grading were 96.1% and 92.2%, respectively, when the UAV flight height was 30 m. For a UAV flight height of 50 m, the accuracies of winter wheat lodging degree and lodging area grading were 84.1% and 84.7%, respectively. These findings indicate that MLP_U-Net is highly robust and efficient in accurately completing the winter wheat lodging-grading task. This valuable insight provides technical references for UAV remote sensing of winter wheat disaster severity and the assessment of losses.
Chinese college students’ mental health during the first three months of the COVID-19 pandemic: the protective role of family functioning
Authors: Zeng Zihao , Holtmaat Karen , Verdonck-de Leeuw Irma M. , Koole Sander L. 
Published: April 2024

BackgroundVarious psychological theories suggest that a supportive family environment protects the mental health of young adults during stressful life events. However, evidence is limited regarding the protective role of family support during a major public health crisis.ObjectiveTo examine the role of family functioning on mental health among Chinese college students during first stage of the COVID-19 pandemic.MethodsBetween January–March 2020, 1,555 college students (44% female, on average 19 years old) from five Chinese universities participated. Participants rated their family functioning on the Family APGAR Index and their mental health on the Psychological Questionnaires for Emergent Events of Public Health, measuring depression, neurasthenia, fear, obsessive-anxiety and hypochondriasis.ResultsBetter family functioning was associated with having fewer psychological symptoms. In addition, we identified three mental health profiles related to the severity across the psychological symptoms: Low-level, medium-level and high-level symptom clusters. Latent profile analysis showed that as family function improved, students were, respectively, 16 to 24% more likely to be in the low-level symptom group, compared to being in the medium symptom group or the high-level symptom group.ConclusionThese results support the notion that family support may act as a psychological buffer for young adults during a large-scale public health crisis like the COVID-19 pandemic.
Safety and oncological outcome of early intraoperative intravesicle mitomycin C vs. deferred instillation in patients receiving robot-assisted radical nephroureterectomy
Authors: Chou Sheng-Feng , Lin Wei-Ching , Chang Han , Huang Chi-Ping 
Published: April 2024

IntroductionRadical nephroureterectomy with concurrent bladder cuff excision (RNUBCE) is the gold standard surgical approach for high-risk primary upper tract urothelial carcinoma (UTUC). Given the notably high incidence of bladder tumor recurrence following this procedure, this study aimed to evaluate the effect and safety of intraoperative mitomycin-C (MMC) instillation vs. deferred instillation on overall oncological outcomes following robot-assisted RNUBCE.MethodsThis is a retrospective chart review study. Patients with non-invasive (N0, not T3/T4) UTUC who underwent robotic RNUBCE combined an intraoperative MMC instillation or a deferred MMC instillation after surgery at a medical center in Taiwan between November 2013 and June 2020 were eligible for inclusion. Patients with prior bladder UC, carcinomas of other origins, received neoadjuvant chemotherapy, and had undergone kidney transplantation were excluded. All surgeries were executed by a single surgical team under the guidance of the same surgeon. The primary outcomes was the risk of bladder tumor recurrence between patients received intraoperative (IO) vs. deferred MMC instillation postoperatively (PO) during one-year follow-up. The secondary outcome was postoperative adverse events assessed by the Clavien–Dindo classification. Univariate and multivariable Cox regression analyses were performed to determine the associations between study variables and the outcomes.ResultsA total of 54 patients were included in the analysis. 12 (22.2%) patients experienced a bladder tumor recurrence during follow-up (IO: 7.7%, PO: 35.7%, p &lt; 0.021). After adjustment in the multivariable, intraoperative MMC instillation was significantly associated with lower risk of bladder recurrence [adjusted hazard ratio (aHR) = 0.15, 95% CI: 0.03–0.81, p = 0.028]. No MMC-related Clavien–Dindo Grade III–IV adverse events were found in either group.ConclusionIIntraoperative MMC instillation is safe and associated with a lower bladder tumor recurrence risk in patients undergoing robotic RNUBCE for UTUC than deferred instillation. Future large, prospective studies are still warranted to confirm the findings.
Un nouveau moteur de recherche étincelant pour les archives d’Ille-et-Vilaine ?
Authors: Le Clerc Jean-Yves , Thomas Romain 
Published: April 2024

Cet article décrit la démarche des Archives départementales d’Ille-et-Vilaine pour aller vers une utilisation pratique du web sémantique à travers l’expérimentation d’une technologie développée par une toute jeune société rennaise, Askelys, qui convertit les bases de données documentaires classiques dans un format sémantique. À l’heure de l’évolution des normes archivistiques de description des archives vers le RiC (Records in Contexts)
et d’une réflexion sur l’accès à leurs fonds dans le cadre d’un projet de service, les Archives départementales d’Ille-et-Vilaine n’ont pas voulu manquer l’opportunité de pouvoir s’engager à tester pendant quelques mois la transformation de leur base de données, riche de centaines de milliers d’occurrences, vers l’eldorado promis d’un résultat précis et ciblé à toute question ou requête dont la réponse se trouverait dans leurs fonds archives. Cela étant rendu possible par le biais de fiches de description, rentrées patiemment dans leurs systèmes d’information successifs depuis plus de 25 ans. L’idée est donc ici de présenter à grands traits la technologie et le mode opératoire utilisés par Askelys pour troquer le laborieux cheval de trait breton qu’était le réservoir de données des Archives départementales d’Ille-et-Vilaine en un fougueux pur-sang, susceptible de répondre au doigt et à l’oeil à toutes les requêtes en rapport avec les innombrables ressources conservées dans leurs fonds. Le confinement et la liquidation de la société n’ont malheureusement pas permis de poursuivre l’expérimentation au-delà de l’intégration de la base de données des archives dans l’outil d’Askelys. L’apprentissage et l’utilisation du moteur de recherche ne reprendront donc pas comme prévu pour montrer ce qui pouvait fonctionner (ou pas), les espoirs, les limites ou les désillusions (s’il y en a !) liés au langage de requête SPARQL en usage dans d’autres portails tels que Persée. Ce test avait aussi pour objectif de nous donner des orientations sur les possibilités d’accès élargies à l’ensemble des corpus conservés par les archives, que ce soit par la description ou par la numérisation.
Extraction of bioactive compounds from food waste and their potential applications in the food industry: a review
Authors: Lankanayaka Ahinsa Anubhashani Kumari , Matharage Dulani Sewwandi , Senanayake Chathuri Maheshika , Jayathunge Kodikara Gedara Lasanthi Renuka , Bandara Pasan Chinthana , Manatunga Danushika Charyangi 
Published: April 2024

The disposal and management of waste have been a burning issue due to the continuous food waste generation in various industrial, agricultural, household, and other food sectors. Fruit and vegetable processing can produce food waste, which can be utilized as a low-cost source of bioactive substances. Natural food additives that extend the shelf life of food are currently of great interest due to the negative health effects associated with prolonged consumption of foods containing artificial food additives. This review describes the important properties of natural bioactive compounds extracted from various fruit and vegetable waste including; antioxidant activities and antimicrobial activities. The primary focus of the present review is to highlight the importance of natural bioactive compounds extracted from food waste as a promising alternative to synthetic additives to extend the shelf-life of food products. The solvent used in the extraction process has a great impact on the quantity and quality of the resulting extract of bioactive compounds. Therefore, even though the same plant material has been used, different solvent extracts lead to different antioxidant activities. The natural bioactive compounds extracted from food waste demonstrated antioxidant and antimicrobial activities that could be used to extend the shelf-life of food products. Increasing the storage stability of natural bioactive compounds is a challenging task that can be achieved via encapsulation. This review suggests that using natural bioactive compounds from leftover fruit and vegetable instead of artificial additives can help prolong the shelf life of food.
ANALISIS SALURAN PEMASARAN DAN MARGIN PEMASARAN BIJI PALA DI DESA BELENGANG KECAMATAN MANGANITU KABUPATEN KEPULAUAN SANGIHE
Authors: Takasihaeng Marfanuel , Rengkung Leonardus Ricky , Lolowang Tommy Ferdy 
Published: April 2024

This study aims to analyze the form of marketing channels and marketing margins of nutmeg in Belengang Village, Manganitu District, Sangihe Islands Regency. The data used in this study are primary and secondary data. Sampling of farmers is done by simple random sampling method and for traders as marketing institutions using the snowball sampling method. The number of farmer samples obtained were 30 farmers. The data is presented in tabular form and analyzed descriptively. The results show that there are 3 forms of marketing channels which are divided into 5 marketing channels: (1) marketing channel level 1: farmers - traders in Tanjung Lelepu district - exporters, (2) marketing channels at 2 levels: farmers - traders in the central district of Tahuna City â€“ traders in the province of Manado City â€“ exporters (b) farmers â€“ traders in Pasar Tamako sub-district â€“ traders in Tanjung Lelepu district â€“ exporters, (3) 3 level marketing channels: (a) farmers â€“ traders in Belengang village â€“ collectors traders in the city center district Tahuna â€“ traders in the province of Manado City â€“ exporters (b) farmers â€“ traders in Pasar Lebo sub-district â€“ traders in the central district of Tahuna City â€“ traders in the province of Manado City â€“ exporters. The highest marketing margin is in marketing channel I with a total margin of Rp 40.800/Kg.
RESPONS HAMA Spodoptera litura F. TERHADAP PESTISIDA BOTANIS Cymbopogon nardus L Rendl., Pangium edule Reinw., dan Syzigium aromaticum L. PADA TANAMAN Brassica olearacea L.
Authors: Kojongian Indra Y. , Rumokoy Laurentius J. M. , Pinaria Betsy A. N. 
Published: April 2024

This study aims to studying the effect of extracts of citronella, pangi leaves, and clove leaves on the mortality of S. litura larvae, the number of S. litura pupae formed and the inhibition of feeding activity of S. litura larvae on cabbage plants. This research was conducted at the Laboratory of the Protection and Quality Testing of Food Crops and Horticulture of North Sulawesi Province and the Laboratory of the Agriculture and Fisheries Service of Tomohon City from November 2020 to July 2021. The research method used a completely randomized design consisting of 3 treatments and 5 replications. The results showed that citronella extract, pangi leaf extract and clove leaf extract could control the mortality of S. litura larvae, the number of pupae of S. litura larvae formed and inhibit the feeding activity of S. litura larvae.
PENDUGAAN DAYA DUKUNG LOKASI WISATA UNTUK MENUNJANG PENGEMBANGAN PARIWISATA YANG BERKELANJUTAN DI PANTAI PAAL, KECAMATAN LIKUPANG TIMUR, KABUPATEN MINAHASA UTARA
Authors: Kapantow Gene H. M. , Tarore Melissa L. G. , Lumingkewas Jelly R. D. 
Published: April 2024

This study aimed to estimate the carrying capacity of Paal Beach tourist sites, East Likupang, one of the main tourist attractions in the Likupang Special Economic Zone (SEZ). This research was conducted from March to November 2021. The data used were primary data and secondary data. Primary data were collected at tourist sites, both from visitors and the Paal Beach management. Secondary data were obtained from tourism site managers and related agencies such as Â Statistics Indonesia Office, Tourism Office, and also gathered from various available documents. The results showed that the Physical Carrying Capacity (PCC) for Paal Beach was 2654 visitors per day, while the Real Carrying Capacity (RCC) and Effective Carrying Capacity (ECC) had the same value, which were 1843 visitors per day. The data showed that the number of visitors on weekdays, weekends and national holidays was still below the PCC. However, there was an ocassion where the number of visitors on a national holiday exceeded the RCC and the ECC.
Analysis of propagation and resonance properties of longitudinal leaky surface acoustic wave on LiNbO3/SiC bonded structure
Authors: Takei Ryo , Suzuki Masashi , Kakio Shoji , Yamamoto Yasushi 
Published: April 2024

Abstract
The propagation and resonance properties of longitudinal leaky surface acoustic waves (LLSAW) on a bonded structure comprising an X-cut LiNbO3 (LN) thin plate and a 4H-SiC support substrate were theoretically investigated. Strong LLSAW responses with high Q factors were obtained at the LN thin-plate thickness h where the LLSAW phase velocity was slower than the bulk shear wave of 4H-SiC of 7126 m s−1, and fractional bandwidth (FBW) of 9%–10% was obtained for Al film thickness normalized by wavelength of h
Al/λ = 0.06–0.07 and h/λ = 0.30–0.40. Moreover, even at h/λ with a faster phase velocity than the bulk shear wave of 4H-SiC, strong LLSAW responses without spurious response owing to the LLSAW higher-order mode were obtained. Finally, h
Al/λ = 0.031 and h/λ = 0.19 were determined to obtain a phase velocity of 7800 m s−1, high Q factors, and FBW of 7.6%.
Mecanismos moleculares en afección miocárdica fetal inducida por diabetes mellitus gestacional: Artículo de Revisión
Authors: Murillo Bargas Héctor , Sánchez Parada María Guadalupe , Gómez Cabrera Alejandro Salvador , González Santiago Ana Elizabeth 
Published: April 2024

Introducción: La Diabetes Mellitus Gestacional (DMG) es una condición metabólica compleja que afecta la salud materna y fetal, la cuál a incrementado su diagnóstico en los últimos años. Se ha asociado con anomalías cardiacas fetales (ACF), por lo que es fundamenteal conocer las bases moleculares de su desarrollo. Objetivo: Analizar literatura científica actual, para identificar mecanismos y vías moleculares clave implicados en la afección miocárdica fetal. Metodología: Consulta de bases de datos Pubmed, Scopus y Web of Science. Las publicaciones consideradas fueron del periodo 2019-2024 y excluyendo artículos que analizaran alteraciones cardíacas fetales no relacionadas con DMG. Resultados: Se reconocieron genes, mecanismos y vías moleculares, así como mecanismos clave en la morfogénesis cardíaca, particularmente vías relacionadas con la hiperglucemia e hiperinsulinemia, desregulación de factores de crecimiento, de genes encargados del desarrollo miocárdico, que conducen a ACF.Conclusión: La hiperglucemia e hiperinsulinemia materna y fetal, conducen a modificación de la expresión de genes y crecimiento celular miocárdico en la ACF asociada con DMG.
Multiwavelength Observations of Multiple Eruptions of the Recurrent Nova M31N 2008-12a
Authors: Basu Judhajeet , Pavana M. , Anupama G. C. , Barway Sudhanshu , Singh Kulinder Pal , Swain Vishwajeet , Srivastav Shubham , Kumar Harsh , Bhalerao Varun , Sonith L. S. , Selvakumar G. 
Published: April 2024

Abstract
We report the optical, UV, and soft X-ray observations of the 2017–2022 eruptions of the recurrent nova M31N 2008-12a. We find a cusp feature in the

r
′

- and

i
′

-band light curves close to the peak, which could be related to jets. The geometry of the nova ejecta based on morpho-kinematic modeling of the Hα emission line indicates an extended jet-like bipolar structure. Spectral modeling indicates an ejecta mass of 10−7–10−8
M
⊙ during each eruption and an enhanced helium abundance. The supersoft source phase shows significant variability, which is anticorrelated to the UV emission, indicating a common origin. The variability could be due to the reformation of the accretion disk. We infer a steady decrease in the accretion rate over the years based on the intereruption recurrence period. A comparison of the accretion rate with different models on the

M

WD

–

M

̇

plane yields the mass of a CO white dwarf, powering the H-shell flashes every ∼1 yr, to be >1.36 M
⊙ and growing with time, making M31N 2008-12a a strong candidate for the single degenerate scenario of the Type Ia supernovae progenitor.
Radio-only and Radio-to-far-ultraviolet Spectral Energy Distribution Modeling of 14 ULIRGs: Insights into the Global Properties of Infrared Bright Galaxies
Authors: Dey Subhrata , Goyal Arti , Małek Katarzyna , Díaz-Santos Tanio 
Published: April 2024

Abstract
We present detailed spectral energy distribution (SED) modeling of 14 local ultraluminous infrared galaxies (ULIRGs) with outstanding photometric data from the literature covering the ultraviolet–infrared (FIR) and radio bands (∼50 MHz to ∼30 GHz). We employ the CIGALE SED fitting code to model the ultraviolet–FIR–radio SED. For the radio-only SED modeling, we use the UltraNest package, leveraging its nested sampling algorithm. Combining the results from our previous study on 11 luminous infrared galaxies (LIRGs), we discuss the global astrophysical properties of a sample of 25 starburst galaxies (z < 0.5). Their radio spectra are frequently characterized by bends and turnovers, with no indication of ULIRGs exhibiting more complicated SEDs than LIRGs despite showing more signs of interactions. Including radio measurements in the CIGALE modeling constrained the dust luminosity and star formation rate (SFR) estimates by more than 1 order of magnitude better than previously reported for starburst galaxies. We show that total and nonthermal radio luminosity at 1.4 and 4.8 GHz frequencies can be good estimators of recent SFRs for all LIRGs and those ULIRGS with an insignificant influence of active galactic nuclei. A weaker but still significant correlation is observed between radio SFRs at 1.4 GHz and old (averaged over 100 Myr) SFRs based on SED modeling, indicative of multiple episodes of starburst activity during their lifetime. The thermal radio luminosity at 4.8 GHz is a better tracer of recent star formation than the thermal luminosity at 1.4 GHz. Statistically, our modeled nonthermal radio spectral indices do not significantly correlate with redshift, stellar mass, SFR, specific SFR, and dust mass.