bluuebunny/crossref_metadata_2025_split huggingface dataset:
Single-cell dissection of prognostic architecture and immunotherapy response inHelicobacter pyloriinfection associated gastric cancer
Authors: Zhang Xin , Zhang Guangyu , Sang Shuli , Fei Yang , Cao Xiaopeng , Song Wenge , Liu Feide , Che Jinze , Tao Haoxia , Wang Hongwei , Zhang Lihua , Guan Yiyan , Rong Shipeng , Pei Lijuan , Yao Sheng , Wang Yanchun , Zhang Min , Liu Chunjie 
Published: May 2024

ABSTRACTMost of the gastric cancer (GC) worldwide are ascribed toHelicobacter pylori(H. pylori) infections, which have a detrimental effect on the immunotherapy’s efficacy. Comprehensively dissecting the key cell players and molecular pathways associated with cancer immunotherapies is critical for developing novel therapeutic strategies againstH. pyloriinfection associated GC. We performed a comprehensive single-cell transcriptome analysis of nine GC with currentH. pyloriinfection (HpGC), three GC with previousH. pyloriinfection (ex-HpGC), six GC withoutH. pyloriinfection (non-HpGC), and six healthy controls (HC). We also investigated key cell players and molecular pathways associated with GC immunotherapy outcomes. We revealed the molecular heterogeneity of different cell components in GC including epithelium, immune cells, and cancer-associated fibroblasts (CAFs) at the single-cell level. The malignant epithelium of HpGC exhibited high expression level of inflammatory and epithelial-mesenchymal transition (EMT) signature, HpGC and ex-HpGC were enriched with VEGFA+ angiogenic tumor-associated macrophages (Angio-TAM) and IL11+ inflammatory CAF (iCAF), characterized by high expression levels of NECTIN2 and VEGFA/B. Additionally, we found significant correlations between the abundance of iCAF with Angio-TAM and TIGIT+ suppressive T cells, and iCAF interacted with Angio-TAM through the VEGF and ANGPTL angiogenic pathways. We also developed an immune signature and angiogenic signature and demonstrated that the iCAF abundance and angiogenic signature could predict poor immunotherapy outcomes in GC.We revealed the transcriptome characteristics and heterogeneity of various cellular constituents of HpGC and demonstrated that a synergistic combination of immunotherapy and anti-angiogenic targeted therapy may be an effective therapeutic modality for HpGC.
Promoting customer satisfaction and reuse intention using ride-hailing taxi services: role of consumer perceived value, personal innovativeness and corporate image
Authors: Vu Tuan Duong , Nguyen Bach Khoa , Vu Phuong Thao , Nguyen Thi My Nguyet , Hoang Cao Cuong 
Published: May 2024

Purpose This study aims to investigate the impact of several factors on customer satisfaction and intention of reusing ride-hailing services that is a new type of passenger urban transport service.Design/methodology/approach This research applied the Partial Least Squares Structural Equation Modeling analysis method to examine the measurement scale and to analyze the primary data collected from 388 passengers in Vietnam.Findings This study demonstrates that three dimensions of perceived value, namely, functional value, hedonic value and economic value, positively influence customer satisfaction. The other dimension of perceived value, which is social value, has an ambiguous effect on satisfaction. In addition, personal innovativeness promotes all dimensions of perceived value. In particular, this study highlights that customer satisfaction and corporate image positively impact reuse intention, and corporate image moderates the relationship between customer satisfaction and reuse intention.Originality/value This study enriches knowledge about customer behavior using services based on the sharing economy business model. In particular, theoretical and practical implications are provided for researchers and enterprises to find suitable strategies for business.
Finding solace in work-family culture as a predictor of work-family enrichment; does gender matter?
Authors: Adu Isaac Nyarko , Owusu Boakye Kwame , Kyei-Frimpong Michael 
Published: May 2024

PurposeThis current study examines the moderating role of gender in the nexus between the dimensions of work-family culture and work-family enrichment in the hospitality industry.Design/methodology/approachThis study employed a cross-sectional survey approach to conveniently gather data from a sample of 296 respondents in the Ghanaian hospitality industry. Both descriptive and inferential statistics were used to examine the data received from the respondents with the aid of IBM SPSS Statistics (V26.0) software and the PROCESS macro for SPSS (V3.5).FindingsAs hypothesised in the study, the dimensions of work-family culture significantly predicted work-family enrichment. Further, the results revealed that gender moderated the nexus between the dimensions of work-family culture and work-family enrichment.Practical implicationsThe findings of this study imply that hotels in the hospitality industry should foster a working environment that embraces a positive work and family culture that ultimately influences the quality of work and family life of an employee, taking into consideration their gender.Originality/valueTo the best of the authors’ knowledge, this current study is amongst the first to examine the moderating role of gender in the nexus between the dimensions of work-family culture and work-family enrichment in the hospitality industry.
When words are key: negotiating meaning in information research
Authors: Tulloch Bonnie J. , Kaczmarek Michelle , Shankar Saguna , Nathan Lisa P. 
Published: May 2024

PurposeThis project set out to explore information scholars’ perceptions of the influence of their keyword selections and the implications of their linguistic choices on possibilities for and perceptions of the field of Information Science. We trialed a narrative methodological approach to investigate the multiple stories told with specific keywords, how they relate to larger discourses within the field and the impact they have on the lives of information researchers.Design/methodology/approachThis paper draws on Arthur Frank’s narrative analysis to consider keywords as stories, which shape one’s sense of professional identity and belonging. The analysis, which is informed by insights from multi-disciplinary scholars of keywords, employs data from a keywords-oriented workshop with Information School faculty and students, as well as an online questionnaire sent to heads of Information Schools.FindingsWe did not find a singular definitive story of information science scholars’ experiences with keywords. Rather we identify tensions surrounding common and contested understandings of discipline, canon and information, engaging the complexity of interdisciplinary, international, intellectual and moral claims of the field. This research offers insight into the experiential factors that shape scholars’ engagement with keywords and the tensions they can create.Originality/valueA wealth of bibliometric analyses of keywords focuses on finding the “right” words to describe the scholarship you seek or the work you want others to discover. However, this study offers information researchers a novel approach, creating space to acknowledge the generative tensions of keywords, beyond the extractive logic of search and retrieval.
Faith in metaverse: understanding adoption intentions of metaverse amongst the Muslim students
Authors: Azhar Mohd , Ali Ruksar , Naz Ariba , Sujood Sujood 
Published: May 2024

Purpose
The purpose of this study is to investigate the antecedents of metaverse adoption intention amongst Muslim students by expanding the technology acceptance model (TAM) to incorporate factors viz. perceived cyber risk (PCR), perceived enjoyment (PE), personal innovativeness in IT (PIT), self-efficacy (SE), trust (TR) and religiosity (RL).

Design/methodology/approach
An online survey was circulated using a Google questionnaire to gather information on the study constructs. Purposive and snowball sampling techniques were adopted to reach the targeted students. The proposed associations were examined through the application of structural equation modelling with the use of AMOS software.

Findings
The findings suggest that the empirical results derived from the study present a compelling and effective model, and the model is designed to elucidate the intentions of Indian Muslim students regarding their willingness to embrace or adopt the metaverse. The research has identified and showcased a robust conceptual framework that provides insights into the factors influencing the metaverse adoption intentions among Muslim students.

Research limitations/implications
This research adds value to the existing literature by expanding the understanding of metaverse adoption amongst Muslim students. This thorough framework offers an intricate comprehension of metaverse adoption, offering a theoretical framework beyond traditional technological determinants. This study provides important insights that can assist educationists, administrators and policymakers in various ways in chalking out essential strategies, policies and programmes related to metaverse adoption amongst Muslim students.

Originality/value
This study is unique as the six additional constructs, viz. PCR, PE, PIT, SE, TR and RL, are included in the original TAM model, thus filling the literature gap. It also augments the comprehension of the metaverse and unfolds the antecedents of metaverse adoption intention amongst Muslim societies through the lens of students.
Using complex adaptive systems (CAS) framework to assess success factors that lead to successful organizational change: a new way to understand change implementation for success
Authors: Riaz Shoaib , Morgan Damian , Kimberley Nell 
Published: May 2024

PurposeThe purpose of this paper is to assess the success factors in a large organization that contributed to the success of organizational transformation (OT) through business diversification using a complex adaptive systems (CAS) framework. This assessment is done to determine how well the CAS framework can explain the success factors that contribute to the success of large-scale organizational change in complex organizations. If the CAS framework is capable of explaining the organizational factors that lead to the success of change implementation, the managers can employ this framework to increase the likelihood of success while implementing change.Design/methodology/approachThis study uses qualitative research methodology. The data were collected from the case study organization (CSO) through 40 in-depth semi-structured interviews and analyzed using thematic deductive analysis approach.FindingsThe CAS framework explains the success factors that contribute to the success of OT through business diversification.Practical implicationsThis paper provides a comprehensive guide for change implementation by combining the insights from the CAS framework with identified success factors (for change implementation) from the case organization.Originality/valueThe originality of this paper lies in extending the principles of existing change models, for successful change implementation by using the CAS framework. The prescribed change models and the CAS framework/complexity theory are two distinct sets of literature; this paper successfully merges the two to develop a comprehensive set of guidelines for change implementation. By doing so, this paper highlights the fact that alternative, non-linear, change approaches, instead of conventional multistep change models, can be effective in implementing large-scale organizational change successfully given the complexities of current organizational environments.
Influencer marketing: explaining the effects of influencer self-presentation strategies on brand responses through source credibility
Authors: van Reijmersdal Eva A. , Walet Marieke , Gudmundsdóttir Andrea 
Published: May 2024

PurposeSelf-presentation is an important aspect of influencer marketing. Drawing upon self-presentation theory and source credibility theory, this study aimed to unravel how the self-presentation strategies of a layperson, opinion leadership and micro-celebrity influence source credibility (i.e. trustworthiness, expertise, physical attractiveness and social attractiveness) and how source credibility, in turn, affects brand responses.Design/methodology/approachAn online experiment among female participants (N = 229) was conducted. Participants were shown a sponsored blog in which the influencer presented herself as either a layperson, an opinion leader or a micro-celebrity.FindingsThe study demonstrated that the presentation strategy of a layperson was more persuasive than a micro-celebrity presentation because of higher levels of (1) trust and (2) social attractiveness. In addition, opinion leaders were perceived as having more expertise than laypeople and, therefore, positively enhanced brand responses.Research limitations/implicationsThe current findings provide relevant insights into the theoretical mechanisms (i.e. expertise, trustworthiness and social attractiveness) that explain the effects of self-presentation strategies on brand responses.Practical implicationsOur findings imply that credibility perceptions determine the persuasiveness of the SMI. This study showed that layperson and opinion leadership self-presentation strategies are relatively more persuasive.Originality/valueThis study is the first to show that influencers’ self-presentation strategies determine how people respond to the brands that influencers promote. In addition, we show that these effects are explained by the influencers’ trust, social attractiveness and expertise.
Will irresistible force overcome immovable object?
Authors: Quiggin John 
Published: May 2024

AbstractLooking at the role of solar photovoltaics in the energy transition is reminiscent of the paradox arising from the clash of an irresistible force and an immovable object. In this note, it will be argued that the irresistible force of low‐cost solar generation will win out over the apparently immovable obstacles.
Mapping the immune cell landscape of severe atopic dermatitis by single‐cell RNA‐seq
Authors: Jin Seon‐Pil , Lee Kyungchun , Bang Yoon Ji , Jeon Yun‐Hui , Jung Sunyoung , Choi So‐Jung , Lee Ji Su , Kim Junhan , Guttman‐Yassky Emma , Park Chung‐Gyu , Kim Hyun Je , Hong Seunghee , Lee Dong Hun 
Published: May 2024

AbstractBackgroundEfforts to profile atopic dermatitis (AD) tissues have intensified, yet comprehensive analysis of systemic immune landscapes in severe AD remains crucial.MethodsEmploying single‐cell RNA sequencing, we analyzed over 300,000 peripheral blood mononuclear cells from 12 severe AD patients (Eczema area and severity index (EASI) > 21) and six healthy controls.ResultsResults revealed significant immune cell shifts in AD patients, including increased Th2 cell abundance, reduced NK cell clusters with compromised cytotoxicity, and correlated Type 2 innate lymphoid cell proportions with disease severity. Moreover, unique monocyte clusters reflecting activated innate immunity emerged in very severe AD (EASI > 30). While overall dendritic cells (DCs) counts decreased, a distinct Th2‐priming subset termed “Th2_DC” correlated strongly with disease severity, validated across skin tissue data, and flow cytometry with additional independent severe AD samples. Beyond the recognized role of Th2 adaptive immunity, our findings highlight significant innate immune cell alterations in severe AD, implicating their roles in disease pathogenesis and therapeutic potentials.ConclusionApart from the widely recognized role of Th2 adaptive immunity in AD pathogenesis, alterations in innate immune cells and impaired cytotoxic cells have also been observed in severe AD. The impact of these alterations on disease pathogenesis and the effectiveness of potential therapeutic targets requires further investigation.
Differentiating placenta accreta spectrum from scar dehiscence with underlying, non‐adherent placenta: A systematic review of scoring systems and primary data analysis
Authors: Adu‐Bredu Theophilus K. , Aryananda Rozi Aditya , Arkorful Joseph , Matthewlynn Sam , Collins Sally L. 
Published: May 2024

AbstractIntroductionAccurate discrimination between placenta accreta spectrum (PAS) and scar dehiscence with underlying non‐adherent placenta is challenging both on prenatal ultrasound and intraoperatively. This can lead to overdiagnosis of PAS and unnecessarily aggressive management of scar dehiscence which increases the risk of morbidity. Several scoring systems have been published which combine clinical and ultrasound information to help diagnose PAS in women at high risk. This research aims to provide insights into the reliability and utility of existing accreta scoring systems in differentiating these two closely related but different conditions to contribute to improved clinical decision making and patient outcomes.Material and MethodsA literature search was performed in four electronic databases. The references of relevant articles were also assessed. The articles were then evaluated according to the predefined inclusion criteria. Primary data for testing each scoring system were obtained retrospectively from two hospitals with specialized PAS services. Each scoring system was used to evaluate the predicted outcome of each case.ResultsThe literature review yielded 15 articles. Of these, eight did not have a clearly described diagnostic criteria for accreta, hence were excluded. Of the remaining seven studies, one was excluded due to unorthodox diagnostic criteria and two were excluded as they differed from the other systems hindering comparison. Four scoring systems were therefore tested with the primary data. All the scoring systems demonstrated higher scores for high‐grade PAS compared to scar dehiscence (p < 0.001) with an excellent Area Under the receiver operator characteristic Curve ranging from 0.82 (95% CI 0.71–0.92) to 0.87 (95% CI 0.79–0.96) in differentiating between these two conditions. However, no statistically significant differences were noted between the low‐grade PAS and scar dehiscence on all scoring systems.ConclusionsMost published scoring systems have no clearly defined diagnostic criteria. Scoring systems can differentiate between scar dehiscence with underlying non‐adherent placenta from high‐grade PAS with excellent diagnostic accuracy, but not for low‐grade PAS. Hence, relying solely on these scoring systems may lead to errors in estimating the risk or extent of the condition which hinders preoperative planning.
Comparing the impact of surgical expert versus non‐ophthalmologist instructors on virtual‐reality surgical performance: A randomized controlled trial
Authors: Boberg‐Ans Lars Christian , Hutter Daniel Ethan , La Cour Morten , Konge Lars , Le Anton , Vangsted Andreas , Thomsen Ann Sofia Skou 
Published: May 2024

AbstractPurposeTo compare Manual Small Incision Cataract Surgery (MSICS) microsurgical performance in course participants who received virtual reality simulation‐based training by either a surgical expert or a non‐ophthalmologist instructor.SettingCopenhagen Academy for Medical Education and Simulation, Copenhagen, Denmark.DesignRandomized controlled trial.MethodsResidents and specialists in ophthalmology with no prior MSICS experience were included to receive virtual reality simulation training in MSICS using the HelpMeSee simulator. The participants were randomly allocated to receive training from either an experienced MSICS surgeon or a non‐ophthalmologist, also known as near‐peer teaching. The performances of the participants were evaluated at baseline and post‐training using a MSICS proficiency‐based test with evidence of validity.ResultsThirty participants were included in the study and 29 completed the course. There was no significant difference in final test score between the two groups (p = 0.13). The performance score of both groups of participants increased significantly after receiving the training (p < 0.001). All participants passed the proficiency‐based test after receiving the training.ConclusionWe found no significant difference in surgical proficiency‐level whether the participants were trained by a surgical expert or a non‐ophthalmologist instructor for MSICS in a virtual‐reality based setting. The findings of this study suggest that near‐peer teaching within microsurgical performance potentially could be applied with teaching outcomes comparable to a surgical expert‐instructor.
Age, GVHD prophylaxis, and timing matter in thrombotic microangiopathy after haematopoietic cell transplantation—A secondary CIBMTR analysis
Authors: Schoettler Michelle L. , Westbrook Adrianna , Watkins Benjamin , Stenger Elizabeth , Qayed Muna , Chonat Satheesh , Williams Kirsten M. 
Published: May 2024

SummaryMost reports of risk factors (RF) for developing transplant‐associated thrombotic microangiopathy (TA‐TMA) and death are derived from paediatric and young adult cohorts, with minimal data on differences in RF and outcomes by age. In this secondary CIBMTR analysis, we used a previously prepared dataset that included all first allogenic haematopoietic cell transplantation (HCT) recipients with malignant or non‐malignant diseases between 2008 and 2016. The incidence of TA‐TMA 6 months post HCT was similar in children and adults 2.1% and 2.0% respectively. Grade 2–4 acute graft‐versus‐host disease (aGVHD) was a significant adjusted RF for developing TA‐TMA in both children and adults. In adults, additional adjusted RFs for TA‐TMA included female sex and black race, and in children an unrelated donor. Compared to a calcineurin inhibitor and sirolimus, other forms of GVHD prophylaxis had an adjusted decreased risk of developing TA‐TMA in adults. Adjusted RF for death in those with TA‐TMA (n = 652) included age ≥18 years old, early onset of TA‐TMA diagnosis (<100 days post HCT), grade 3–4 aGVHD and a performance score of <90 prior to HCT. In this cohort, the incidence of TA‐TMA was similar in children and adults, and TA‐TMA timing was a newly identified RF for death.
QPGx‐CARES: Qatar pharmacogenetics clinical applications and research enhancement strategies
Authors: Abdel‐latif Rania , Badji Radja , Mohammed Shaban , Al‐Muftah Wadha , Mbarek Hamdi , Darwish Dima , Assaf Duha , Al‐Badriyeh Daoud , Elewa Hazem , Afifi Nahla , Masoodi Naseer Ahmad , Omar Amr Salah , Al Suwaidi Jassim , Bujassoum Salha , Al Hail Moza , Ismail Said I. , Althani Asma 
Published: May 2024

AbstractPharmacogenetic (PGx)‐informed medication prescription is a cutting‐edge genomic application in contemporary medicine, offering the potential to overcome the conventional “trial‐and‐error” approach in drug prescription. The ability to use an individual's genetic profile to predict drug responses allows for personalized drug and dosage selection, thereby enhancing the safety and efficacy of treatments. However, despite significant scientific and clinical advancements in PGx, its integration into routine healthcare practices remains limited. To address this gap, the Qatar Genome Program (QGP) has embarked on an ambitious initiative known as QPGx‐CARES (Qatar Pharmacogenetics Clinical Applications and Research Enhancement Strategies), which aims to set a roadmap for optimizing PGx research and clinical implementation on a national scale. The goal of QPGx‐CARES initiative is to integrate PGx testing into clinical settings with the aim of improving patient health outcomes. In 2022, QGP initiated several implementation projects in various clinical settings. These projects aimed to evaluate the clinical utility of PGx testing, gather valuable insights into the effective dissemination of PGx data to healthcare professionals and patients, and identify the gaps and the challenges for wider adoption. QPGx‐CARES strategy aimed to integrate evidence‐based PGx findings into clinical practice, focusing on implementing PGx testing for cardiovascular medications, supported by robust scientific evidence. The current initiative sets a precedent for the nationwide implementation of precision medicine across diverse clinical domains.