bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Association Between Hospital-Based Food Pantry Use and Subsequent Emergency Department Utilization Among Medicaid Patients With Diabetes
Authors: Lim Kenneth , Nguyen Kevin H. , Goutos Demetri , Shafer Paul R. , Buitron de la Vega Pablo , Cole Megan B. 
Published: May 2024

We explored the association between the use of a hospital-based food pantry and subsequent emergency department (ED) utilization among Medicaid patients with diabetes in a large safety-net health system. Leveraging 2015-2019 electronic health record data, we used a staggered difference-in-differences approach to measure changes in ED use before vs after food pantry use. Food pantry use was associated with a 7.3 percentage point decrease per patient per quarter (95% confidence interval, −13.8 to −0.8) in the probability of subsequent ED utilization (P = .03). Addressing food insecurity through hospital-based food pantries may be one mechanism for reducing ED use among low-income patients with diabetes.
New Horizons in Emergency Department Management of Pediatric Sickle Cell Disease
Authors: Umana Jasmine , Lapite Ajibike , Ellison Angela M. 
Published: May 2024

Abstract
Sickle cell disease (SCD) is an important topic for emergency medicine audiences because complications of the disease account for a large proportion of hematologic emergencies that are seen in the emergency department each year. Early recognition and aggressive management of emergency complications of SCD can help to reduce the morbidity and mortality associated with this disease. Although the treatment recommendations for some complications of SCD are based on expert opinion, there has been advancement in the understanding of the pathogenesis of the disease and evidence regarding the treatment options available for managing acute complications. This continuing medical education article will provide a summary of the clinical manifestation and management of the most common acute complications of SCD: infection, vaso-occlusive episode, acute chest syndrome, splenic sequestration, stroke, and priapism.
Contralateral Autologous Augmentation in DIEP Flap Reconstruction: Employing Computed Tomography Angiography and Volumetric Analysis for Preoperative Planning
Authors: Hespe Geoffrey E. , Sugg Kristoffer B. , Stein Erica B. , Ellsworth Warren A. , Kung Theodore A. , Momoh Adeyiza O. 
Published: May 2024

Summary:
Autologous reconstruction accounts for approximately 20% of all breast reconstruction procedures. In cases of unilateral reconstruction, contralateral breast augmentation using autologous tissue can be performed to improve symmetry, and it is a viable option for patients interested in having more volume relative to their current size without the use of implants. Computed tomography scans have been used for preoperative planning in autologous reconstruction to evaluate available perforators. In this article, the authors report their experience using computed tomography angiography for preoperative volumetric assessment for autologous contralateral breast augmentation in the setting of unilateral autologous breast reconstruction. Twelve patients underwent autologous augmentation during the study period. The average reconstruction flap weight was 561.2 ± 253.6 g, and the average augmentation flap weight was 218.0 ± 133.7 g. No patients experienced flap loss. The authors demonstrate that the predicted volumes for the augmented and reconstructed breasts were comparable to the actual respective flap volumes. In addition, postoperative patient-reported outcome measures demonstrated high levels of satisfaction across multiple BREAST-Q subscales. This study demonstrates the utility of using computed tomography angiography to estimate reconstructive volumes to help preoperative planning and achieve predictable postoperative breast volumes. It also supports that contralateral autologous augmentation is a good option for patients who would like to avoid implants and are interested in a small to moderate increase in size.

CLINICAL QUESTION/LEVEL OF EVIDENCE:
Therapeutic, IV.
Bone morphogenetic protein (BMP) signaling determines neuroblastoma cell fate and sensitivity to retinoic acid
Authors: Pan Min , Zhang Yinwen , Wright William C. , Liu Xueying , Passaia Barbara , Currier Duane , Low Jonathan , Chapple Richard H. , Steele Jacob A. , Connelly Jon P. , Lu Meifen , Lee Hyeong-Min , Loughran Allister J. , Yang Lei , Abraham Brian J , Pruett-Miller Shondra M. , Freeman Burgess , Campbell George E. , Dyer Michael A. , Chen Taosheng , Stewart Elizabeth , Koo Selene , Sheppard Heather , Easton John , Geeleher Paul 
Published: May 2024

SUMMARYRetinoic acid (RA) is a standard-of-care neuroblastoma drug thought to be effective by inducing differentiation. Curiously, RA has little effect on primary human tumors during upfront treatment but can eliminate neuroblastoma cells from the bone marrow during post-chemo consolidation therapy—a discrepancy that has never been explained. To investigate this, we treated a large cohort of neuroblastoma cell lines with RA and observed that the most RA-sensitive cells predominantly undergo apoptosis or senescence, rather than differentiation. We conducted genome-wide CRISPR knockout screens under RA treatment, which identified BMP signaling as controlling the apoptosis/senescence vs differentiation cell fate decision and determining RA’s overall potency. We then discovered that BMP signaling activity is markedly higher in neuroblastoma patient samples at bone marrow metastatic sites, providing a plausible explanation for RA’s ability to clear neuroblastoma cells specifically from the bone marrow, seemingly mimicking interactions between BMP and RA during normal development.
WITHDRAWN: Apelin-13 alleviate inflammatory reaction of ischemia reperfusion in rat kidney transplantation via NF-kappa B signaling pathway
Authors: Capelli Irene , Aiello Valeria , Gasperoni Lorenzo , Manna Gaetano La 
Published: May 2024

Withdrawal statementThis manuscript has been withdrawn after a request from the Dean of the Department of Medical and Surgical Sciences (DIMEC) at the University of Bologna. This manuscript constitutes a fraudulent submission by a third party impersonating Prof. Gaetano La Manna of said university. The email address listed for the corresponding author is invalid and not the institutional email address of Prof. La Manna, a member of DIMEC. Additionally, there are no other faculty members or researchers named Gaetano La Manna employed at the University of Bologna (UNIBO). Furthermore, the department (DIMES) associated with the publication in question was dissolved on December 31, 2022, and no longer exists.The individuals falsely listed as authors were not responsible for its submission and have no knowledge of or involvement in the work presented. Therefore, this article should not be cited as reference for this project.
Ferroptosis mediates the progression of hyperuricemic nephropathy by activating RAGE signaling
Authors: Wang Qiang , Xi Yuemei , Zhao Hairong , Xie De , Yu Linqian , Yan Yunbo , Chen Jiayu , Zhang Qian , Liang Meng , Cheng Jidong 
Published: May 2024

AbstractHyperuricemic nephropathy (HN) represents a prevalent complication arising from hyperuricemia, typified by tubular dysfunction, inflammation, and progressive renal fibrosis, whose pathogenic mechanisms remain enigmatic. Ferroptosis, a newly elucidated iron-dependent form of regulated cell death, plays a role in various disease states. However, its involvement in HN has seldom been explored. In this study, we observed indications of ferroptosis in the renal tissues of urate oxidase knockout (UOX-/-) mice, a model of hyperuricemia, as evidenced by increased iron deposition and reduced expression of glutathione peroxidase 4 (GPX4). These findings suggest a substantial role of ferroptosis in the pathogenesis of HN. To further explore this hypothesis, UOX-/-mice were administered Ferrostatin-1, a known inhibitor ferroptosis. This treatment markedly ameliorated tubular injury, necrosis, and inflammatory cell infiltration, mitigated renal fibrosis, reinstated the expression of proteins associated with ferroptosis in renal tissues, and reduced iron overload, lipid peroxidation, and mitochondrial damage in UOX-/-mice. Additionally, we found that receptor for advanced glycation end products (RAGE) propagates ferroptosis-induced renal injury, inflammation and fibrosis, albeit without directly facilitating ferroptosis. Finally, ferroptosis and RAGE upregulation were validated in renal tissues of patients with hyperuricemia-related kidney disease. Collectively, our research elucidates the critical contribution of ferroptosis to HN pathogenesis, indicating that therapeutic strategies targeting ferroptosis and the related RAGE signaling may offer novel therapeutic approaches for managing this condition.
Persistent Activation of Chronic Inflammatory Pathways in Long Covid
Authors: Aid Malika , McMahan Katherine , Hachmann Nicole P , Miller Jessica , Borducchi Erica , Hope David , Rowe Marjorie , Schonberg Eleanor , Thai Siline , Collier Ai-ris Y. , Mullington Janet , Barouch Dan H. 
Published: May 2024

AbstractLong Covid, or Post-Acute Sequelae of COVID-19 (PASC), involves a spectrum of chronic symptoms following resolution of acute SARS-CoV-2 infection. Current hypotheses for the pathogenesis of Long Covid include persistent SARS-CoV-2, activation of other viruses, tissue damage, autoimmunity, endocrine insufficiency, immune dysfunction, and complement activation. We evaluated 142 participants, including uninfected controls (N=35), acutely infected individuals (N=54), convalescent controls (N=25), and Long Covid patients (N=28), by comprehensive immunologic, virologic, transcriptomic, and proteomic analyses. Long Covid was characterized by persistent inflammatory pathways compared with convalescent controls and uninfected controls, including upregulation of IL-6 and JAK-STAT pathways as well as activation of coagulation, complement, metabolism, and T cell exhaustion pathways. Moreover, robust activation of these pathways during acute COVID-19 infection correlated with the subsequent development of Long Covid. In an independent validation cohort (N=47), Long Covid patients had higher levels of plasma IL-6R compared with convalescent controls and uninfected controls. These data demonstrate that Long Covid is characterized by persistent activation of chronic inflammatory pathways, suggesting novel therapeutic targets and biomarkers of disease.
Cyclic di-AMP regulates genome stability and drug resistance in Mycobacterium through RecA-dependent and -independent recombination
Authors: Mudgal Sudhanshu , Goyal Nisha , Manikandan Kasi , Saginela Rahul , Singhal Anusha , Nandi Soumyadeep , Muniyappa K. , Sinha Krishna Murari 
Published: May 2024

AbstractInEscherichia coli, RecA plays a central role in the rescue of stalled replication forks, double-strand break (DSB) repair, homologous recombination (HR) and induction of the SOS response. While the RecA-dependent pathway is dominant, alternative HR pathways that function independently of RecA do exist, but relatively little is known about the underlying mechanism. Several studies have documented that a variety of proteins act either as positive or negative regulators of RecA to ensure high-fidelity HR and genomic stability. Along these lines, we previously demonstrated that the second messenger cyclic di-AMP binds to mycobacterial RecA proteins, but notE. coliRecA, and inhibits its DNA strand exchange activityin vitrovia the disassembly of RecA nucleoprotein filaments. Herein, we demonstrate thatMycobacterium smegmatis ΔdisAcells, which lack c-di-AMP, exhibit increased DNA recombination, higher frequency of mutation and gene duplications during RecA-dependent and RecA-independent DSB repair. We also found that c-di-AMP regulates SOS response by inhibiting RecA-mediated self-cleavage of LexA repressor and its absence enhances drug resistance inM. smegmatis ΔdisAcells. Together, our results uncover a role of c-di-AMP in the maintenance of genomic stability through modulation of DSB repair inM. smegmatis.SignificanceCyclic di-AMP is a second messenger present in bacteria and archaea and is implicated in a variety of functions in the cell, including DNA repair, cell wall metabolism, virulence, and gene expression. We show here that it maintains genome stability in Mycobacterium by regulating RecA-dependent and –independent DNA recombination pathways. It also regulates SOS response by inhibiting the self-cleavage of LexA by mycobacterial RecA. Absence of c-di-AMP leads to higher drug resistance in Mycobacterium.
Genetic and Epigenetic Characterization of Sarcoma Stem Cells Across Subtypes Identifies EZH2 as a Therapeutic Target
Authors: O’Donnell Edmond , Muñoz Maria , Davis Ryan , Randall R. Lor , Tepper Clifford , Carr-Ascher Janai 
Published: May 2024

AbstractHigh-grade complex karyotype soft tissue sarcomas (STS) are a heterogeneous and aggressive set of cancers that share a common treatment strategy. Disease progression and failure to respond to anthracycline based chemotherapy, standard first-line treatment, is associated with poor patient outcomes. To address this, we investigated the contribution of STS cancer stem cells (STS-CSCs) to doxorubicin resistance. We identified a positive correlation between CSC abundance and doxorubicin IC50in resistant cell lines. We investigated if a common genetic signature across STS-CSCs could be targeted. Utilizing patient derived samples from five sarcoma subtypes we identified Enhancer of Zeste homolog 2 (EZH2), a member of the polycomb repressive complex 2 (PRC2) responsible for H3K27 methylation as being enriched in the CSC population. EZH2 activity and a shared epigenetic profile was observed across subtypes. Targeting of EZH2 using Tazemetostat, an FDA approved inhibitor specifically ablated the STS-CSC population. Treatment of doxorubicin resistant cell lines with tazemetostat resulted in a decrease in the STS-CSC population. Further, co-treatment was not only synergistic in the parent cell lines, but restored chemosensitivity in doxorubicin resistant lines. These data confirm the presence of shared genetic programs across distinct subtypes of CSC-STS that can be therapeutically targeted.
Evolutionary game of incentive strategy for Chinese prefabricated buildings based on system dynamics from the perspective of prospect theory
Authors: Pan Haize , Yang Bingfeng , Pan Yongwei , Luo Zhenhua 
Published: May 2024

PurposeAs an effective measure for reducing energy consumption and achieving carbon neutrality, prefabricated building projects (PBPs) have attracted considerable attention in China. Although the Chinese Government has vigorously promoted PBPs, neither developers nor consumers have high recognition of PBPs. This study aimed to explore the decision-making behaviour of governments, developers and consumers in promoting the development of prefabricated buildings in China and to better optimise the incentive strategies for prefabricated buildings in China.Design/methodology/approachBased on prospect and evolutionary game theories, an evolutionary game model of three stakeholders in the development of PBPs – government, developers and consumers – was constructed. Combined with the system dynamics theory, the incentive policy behaviour and influencing factors of the three parties in the evolutionary game model were analysed.FindingsThe results showed that the initial probability of the three parties affects the decision-making behaviour of each party and that of other stakeholders. Government subsidies to developers are more sensitive than developers themselves. There is a certain threshold for the scope of government subsidies to consumers, and exceeding this threshold does not promote the development of PBPs. Based on the results, policy recommendations to the government, developers and consumers were proposed to enhance PBP development.Originality/valueThis study provides suggestions for governments to formulate reasonable incentive policies for prefabricated buildings and a specific theoretical basis for the sound development of prefabricated buildings.
The role of renewable energy and foreign direct investment toward environmental degradation convergence to achieve sustainability: evidence from ASEAN countries
Authors: Kurniawan Robert , Kusuma Arya Candra , Sumargo Bagus , Gio Prana Ugiana , Wongsonadi Sri Kuswantono , Sasmita Karta 
Published: May 2024

Purpose
This study aims to analyze the convergence of environmental degradation clubs in the Association of Southeast Asian Nations (ASEAN). In addition, this study also analyzes the influence of renewable energy and foreign direct investment (FDI) on each club as an intervention to change the convergence pattern in each club.

Design/methodology/approach
This study analyzes the club convergence of environmental degradation in an effort to find out the distribution of environmental degradation reduction policies. This study uses club convergence with the Phillips and Sul (PS) convergence methodology because it considers multiple steady-states and is robust. This study uses annual panel data from 1998 to 2020 and ASEAN country units with ecological footprints as proxies for environmental degradation. After obtaining the club results, the analysis continued by analyzing the impact of renewable energy and FDI on each club using panel data regression and the Stochastic Impacts by Regression on Population, Affluence and Technology model specification.

Findings
Based on club convergence, ASEAN countries can be grouped into three clubs with two divergent countries. Club 1 has an increasing pattern of environmental degradation, while Club 2 and Club 3 show no increase. Club 1 can primarily apply renewable energy to reduce environmental degradation, while Club 2 requires more FDI. The authors expect policymakers to take into account the clubs established to formulate collaborative policies among countries. The result that FDI reduces environmental degradation in this study is in line with the pollution halo hypothesis. This study also found that population has a significant effect on environmental degradation, so policies to regulate population need to be considered. On the other hand, increasing income has no effect on reducing environmental degradation. Therefore, the use of renewable energy and FDI toward green investment is expected to intensify within ASEAN countries to reduce environmental degradation.

Originality/value
This research is by far the first to apply PS Club convergence to environmental degradation in ASEAN. In addition, this study is also the first to analyze the influence of renewable energy and FDI on each club formed, considering the need for renewable energy use that has not been maximized in ASEAN.
Comprehensive assessment of green hydrogen potential in Jordan: economic, environmental and social perspectives
Authors: Shboul Bashar , Zayed Mohamed E. , Marashdeh Hadi F. , Al-Smad Sondos N. , Al-Bourini Ahmad A. , Amer Bessan J. , Qtashat Zainab W. , Alhourani Alanoud M. 
Published: May 2024

Purpose
This paper aims to assess the economic, environmental, policy-related and social implications of establishing green hydrogen production in Jordan.

Design/methodology/approach
The comprehensive analysis has been investigated, including economic assessments, environmental impact evaluations, policy examinations and social considerations. Furthermore, the research methodology encompasses energy demand, sector, security and supply analysis, as well as an assessment of the availability of renewable energy resources.

Findings
The results indicate substantial economic benefits associated with green hydrogen production, including job creation, increased tax revenue and a reduction in energy imports. Additionally, the study identifies positive environmental impacts, such as decreased greenhouse gas emissions and air pollution. Noteworthy, two methods could be used to produce hydrogen, namely: electrolysis and thermochemical water splitting. As a recommendation, the study proposes that Jordan, particularly Aqaba, take proactive measures to foster the development of a green hydrogen industry and collaborate with international partners to exchange best practices and establish the necessary infrastructure.

Originality/value
To the best of the authors’ knowledge, this paper is among the first to provide a comprehensive perspective on the potential of green hydrogen production as a driving force for Jordan’s economy, while also benefiting the environment and society. However, the research recognizes several challenges that must be addressed to materialize green hydrogen production in Jordan, encompassing high renewable energy costs, infrastructure development requirements and community concerns. Despite these obstacles, the study asserts that the potential advantages of green hydrogen production outweigh the associated risks.
Developing an assessment framework of smartized upscale hotel workforce employability from the practitioners' perspective
Authors: Fang Ching Ching , Liou James 
Published: May 2024

PurposeWorkforce insufficiencies can impair firms' competitiveness in the hospitality industry. The problem of finding suitably trained employees has been aggravated by changes in consumer preferences, and the development of advanced technologies has led to the ‘smartization’ of upscale hotels. The consequent updating of business models means that decisive indicators of worker competence and employability are different from those applied previously. Thus, the aim of this study is to develop an indicator framework for assessing workforce employability with consideration of competence with artificial intelligence (AI) applications.Design/methodology/approachThe initial indicators for the framework are obtained based on an intensive review of the relevant literature and roundtable meetings with academics and practitioners. The Delphi method is used to collect the data, and a hybrid fuzzy approach, which combines the modified Z-number and modified trapezoidal fuzzy number set techniques, is applied to quantify the information originating from the experts’ judgments. The interquartile range approach is applied to optimize the validity of the indicators.FindingsThe assessment framework is applied to evaluate workforce employability at an upscale hotel from the perspective of hotel executives. The capability of the workforce for the adoption of advanced technologies, including familiarity with AI, are considered.Originality/valueThe contributions of this research involve the identification of an updated list of determinants for the evaluation of workforce employability for hotels in today’s world, highlighting the value of AI applications to help ameliorate labor shortage problems. The results should benefit practitioners, allowing them to improve the efficiency of their operations, services and management practices, leading to sustainability and competitiveness in the upscale hotel industry.