bluuebunny/crossref_metadata_2025_split huggingface dataset:
How cognitive performance‐induced stress can influence right VLPFC activation: An fMRI study in healthy subjects and in patients with social phobia
Authors: Koric Lejla , Volle Emmanuelle , Seassau Magali , Bernard Frédéric A. , Mancini Julien , Dubois Bruno , Pelissolo Antoine , Levy Richard 
Published: July 2011

AbstractThe neural bases of interactions between anxiety and cognitive control are not fully understood. We conducted an fMRI study in healthy participants and in patients with an anxiety disorder (social phobia) to determine the impact of stress on the brain network involved in cognitive control. Participants performed two working memory tasks that differed in their level of performance‐induced stress. In both groups, the cognitive tasks activated a frontoparietal network, involved in working memory tasks. A supplementary activation was observed in the right ventrolateral prefrontal cortex (VLPFC) in patients during the more stressful cognitive task. Region of interest analyses showed that activation in the right VLPFC decreased in the more stressful condition as compared to the less stressful one in healthy subjects and remain at a similar level in the two cognitive tasks in patients. This pattern was specific to the right when compared to the left VLPFC activation. Anxiety was positively correlated with right VLPFC activation across groups. Finally, left dorsolateral prefrontal cortex (DLPFC) activation was higher in healthy subjects than in patients in the more stressful task. These findings demonstrate that in healthy subjects, stress induces an increased activation in left DLPFC, a critical region for cognitive control, and a decreased activation in the right VLPFC, an area associated with anxiety. In patients, the differential modulation between these dorsal and ventral PFC regions disappears. This absence of modulation may limit anxious patients' ability to adapt to demanding cognitive control tasks. Hum Brain Mapp, 2012. © 2011 Wiley Periodicals, Inc
First Stereoselective Total Synthesis of Gallicynoic Acids G and H
Authors: Radha Krishna Palakodety , Anitha Kadimi 
Published: July 2011

AbstractA stereoselective convergent total synthesis of two acetylenic acids, gallicynoic acid G (1) and H (2), is reported, involving asymmetric reduction of alkynones 3 and 4, respectively, with the Corey BakshiSibata (CBS) catalyst as a key step (Scheme 3), 3 and 4 being obtained from a common intermediate, the chiral alkynol 12 (Scheme 2).
A Novel Synthesis of Isoflavones via Copper(I)‐Catalyzed Intramolecular Cyclization Reaction
Authors: Li Qiu‐Lian , Liu Qi‐Lun , Ge Zhi‐Yuan , Zhu Yong‐Ming 
Published: July 2011

AbstractIsoflavone derivatives were synthesized via intramolecular cyclization of 3‐(2‐bromophenyl)‐3‐oxopropanal derivatives, using CuI as the catalyst, 2‐picolinic acid (=pyridine‐2‐carboxylic acid) as the ligand, K2CO3 as the base, and DMF as the solvent, in up to 96% yield. The synthesis is functional group‐tolerant.
Sesquiterpenoids from Fusarium sp., an Endophytic Fungus in Agriminia pilosa
Authors: Shan Wei‐Guang , Chen Xiao‐Xiao , Ying You‐Min , Zhan Zha‐Jun 
Published: July 2011

AbstractCultivation of the endophytic fungus isolated from the stems of Agriminia pilosa provided four new sesquiterpenoids, namely agripilols A–D (1–4, resp.). Structures of these isolates were elucidated by NMR and MS data. The isolation of drimane‐ and cadinane‐type sesquiterpenoids from the genus of Fusarium is reported for the first time.
Sesquiterpenoids from the Aerial Parts of Inula japonica
Authors: Gong Hai‐Qun , Wu Quan‐Xiang , Liu Lei‐Lei , Yang Jun‐Li , Wang Rui , Shi Yan‐Ping 
Published: July 2011

AbstractFourteen sesquiterpenoids with an eudesmane C‐atom skeleton, including four new ones, (1β,5α,7β,8β,11β)‐5‐hydroperoxy‐1‐hydroxyeudesm‐4(15)‐eno‐12,8‐lactone (1), (1β,5α,7β,8β)‐8‐(acetyloxy)‐5‐hydroperoxy‐1‐hydroxycostic acid methyl ester (12), and a mixture of (1β,3β,4β,7β,8β)‐1,3‐dihydroxyeudesma‐5,11(13)‐dieno‐12,8‐lactone (7) and (1β,3β,4β,7β,8β,11β)‐1,3‐dihydroxyeudesm‐5‐eno‐12,8‐lactone (8), were isolated from the aerial parts of Inula japonica (Asteraceae). Their structures were determined by extensive spectroscopic methods, and those of 7 and 12 confirmed by means of single‐crystal X‐ray diffraction analysis.
Two New Phenolic Compounds from the Rhizomes of Gastrodia elataBlume
Authors: Han Ah‐Reum , Ji Shin Hyun , Rim Jeon Ha , Lee Je‐Hyun , Lee Dongho , Seo Eun‐Kyoung 
Published: July 2011

AbstractPhytochemical investigation of the rhizomes of Gastrodia elata Blume (Orchidaceae) led to the isolation and identification of twelve compounds, including two new phenolic compounds, 4‐hydroxybenzyl vanillyl ether (=4‐{[(4‐hydroxyphenyl)methoxy]methyl}‐2‐methoxyphenol; 1) and 4‐{{4‐[4‐(methoxymethyl)phenoxy]benzyl}oxy}benzyl methyl ether (=1‐[4‐(methoxymethyl)phenoxy]‐4‐{[4‐(methoxymethyl)phenoxy]methyl}benzene; 2). The structures of 1 and 2 were elucidated by spectroscopic data analysis including 1D‐ and 2D‐NMR experiments.
First Total Synthesis of Prionoid E, A Bioactive Rearranged Secoabietane Diterpene Quinone from Salvia prionitis
Authors: Deng Fei , Xu Jun , Zhao Min , Liu Hong‐Ying , Ye Yang , Zhang Jin‐Sheng 
Published: July 2011

AbstractThe first total synthesis of prionoid E (1), a rearranged secoabietane diterpene quinone isolated from Salvia prionitis, was achieved efficiently by means of Wacker oxidation (Scheme 5) and aldol condensation (Scheme 7) as the key steps in the synthetic sequence. Thus 1 was prepared in 15 steps in 3.7% yield starting on one hand from anisole (=methoxybenzene) and methylsuccinic anhydride (=dihydro‐3‐methylfuran‐2,5‐dione) via 4 (Scheme 3 and 5), and on the other hand from 2‐hydroxy‐2‐methylpropanoic acid via 5 (Scheme 6).
Two New Steroidal Saponins from the Fresh Leaves of Agave sisalana
Authors: Yu He‐Shui , Zou Peng , Song Xin‐Bo , Kang Li‐Ping , Liu Yi‐Xun , Pang Xu , Zhang Jie , Fu Jing , Zhao Yang , Xiong Cheng‐Qi , Tan Da‐Wei , Zhang Li‐Juan , Ma Bai‐Ping 
Published: July 2011

AbstractA new furostanol saponin, sisalasaponin C (1), and a new spirostanol saponin, sisalasaponin D (2), were isolated from the fresh leaves of Agave sisalana, along with three other known steroidal saponins and two stilbenes. Their structures were identified as (3β,5α,6α,22α,25R)‐3,26‐bis[(β‐D‐glucopyrano‐ syl)oxy]‐22‐hydroxyfurostan‐6‐yl β‐D‐glucopyranoside (1), (3β,5α,25R)‐12‐oxospirostan‐3‐yl 6‐deoxy‐α‐L‐mannopyranosyl‐(1→4)‐β‐D‐glucopyranosyl‐(1→3)‐[β‐D‐xylopyranosyl‐(1→3)‐β‐D‐glucopyranosyl‐(1→2)]‐β‐D‐glucopyranosyl‐(1→4)‐β‐D‐galactopyranoside (2), (3β,5α,6α,22α,25R)‐22‐methoxyfurostane‐3,6,26‐triyl tris‐β‐D‐glucopyranoside, cantalasaponin‐1, polianthoside D, (E)‐ and (Z)‐2,3,4′,5‐tetrahydroxystilbene 2‐O‐β‐D‐glucopyranosides. The last three known compounds were isolated from the fresh leaves of Agavaceae for the first time. The structures of the new compounds were elucidated by detailed spectroscopic analysis, including 1D‐ and 2D‐NMR experiments, and chemical techniques.
Introduction of Adjacent Oxygen‐Functionalities in Dimethyl Heptalenedicarboxylates
Authors: Rogano Frank , Stojnic Danijela , Linden Anthony , Abou‐Hadeed Khaled , Hansen Hans‐Jürgen 
Published: July 2011

AbstractThe bromination of dimethyl 8‐methoxy‐1,6,10‐trimethylheptalene‐4,5‐dicarboxylate (6; Scheme 2) with N‐bromosuccinimide (NBS) in N,N‐dimethylformamide (DMF) leads in acceptable yields to the corresponding 9‐bromoheptalenedicarboxylate 10 (Table 1). Ether cleavage of 6 with chlorotrimethylsilane (Me3SiCl)/NaI results in the formation of oxoheptalenedicarboxylate 13 in good yield (Scheme 4). The latter can be acetyloxylated to the (acetyloxy)oxoheptalenedicarboxylate 14 with Pb(OAc)4 in benzene (Scheme 5). Oxo derivative 14, in turn, can be selectively O‐methylated with dimethyl sulfate (DMS) in acetone to the (acetyloxy)methoxyheptalenedicarboxylates 15 and 15′ (Scheme 6). The AcO group of the latter can be transformed into a benzyl or methyl ether group by treatment with MeONa in DMF, followed by the addition of benzyl bromide or methyl iodide (cf. Scheme 9). Reduction of the ester groups of dimethyl 7,8‐dimethoxy‐5,6,10‐trimethylheptalene‐1,2‐dicarboxylate (25′) with diisobutylaluminium hydride (DIBAH) in tetrahydrofuran (THF) leads to the formation of the corresponding dimethanol 26′, which can be cyclized oxidatively (IBX, dimethyl sulfoxide) to 8,9‐dimethoxy‐6,7,11‐trimethylheptaleno[1,2‐c]furan (27; Scheme 11).
Infants placed in foster care prior to their first birthday: Differences in kin and nonkin placements
Authors: Stacks Ann M. , Partridge Ty 
Published: July 2011

AbstractUsing data from the National Survey of Child and Adolescent Well‐Being, this study examines differences between kinship and foster placements for infants placed in out‐of‐home care prior to their first birthday. The differences examined include developmental status at time of placement, differences in the home and neighborhood environments, and the duration of time in placement. Participants included 457 infants placed in either kinship or foster care and their caregivers. Findings suggest that infants placed with kin had fewer developmental concerns 2 to 6 months after the initial Child Protective Services investigation and spent significantly less time in placement. The quality of foster and kinship homes and neighborhoods also differed: Foster homes were generally of better quality and located in safer neighborhoods. Overall, for both kin and foster care, the data suggest that even after passage of the Adoption and Safe Families Act of 1997 (ASFA, Public Law 105‐89), infants remain in care for a long time: Approximately one third of infants are still in out‐of‐home care 3 years after the initial investigation.
The structure and function of the rous sarcoma virus RNA stability element
Authors: Withers Johanna B. , Beemon Karen L. 
Published: July 2011

AbstractFor simple retroviruses, such as the Rous sarcoma virus (RSV), post‐transcriptional control elements regulate viral RNA splicing, export, stability, and packaging into virions. These RNA sequences interact with cellular host proteins to regulate and facilitate productive viral infections. One such element, known as the RSV stability element (RSE), is required for maintaining stability of the full‐length unspliced RNA. This viral RNA serves as the mRNA for the Gag and Pol proteins and also as the genome packaged in progeny virions. When the RSE is deleted from the viral RNA, the unspliced RNA becomes unstable and is degraded in a Upf1‐dependent manner. Current evidence suggests that the RSE inhibits recognition of the viral gag termination codon by the nonsense‐mediated mRNA decay (NMD) pathway. We believe that the RSE acts as an insulator to NMD, thereby preventing at least one of the required functional steps that target an mRNA for degradation. Here, we discuss the history of the RSE and the current model of how the RSE is interacting with cellular NMD factors. J. Cell. Biochem. 112: 3085–3092, 2011. © 2011 Wiley Periodicals, Inc.
Autophagy in hypoxia protects cancer cells against apoptosis induced by nutrient deprivation through a beclin1‐dependent way in hepatocellular carcinoma
Authors: Song Jianrui , Guo Xianling , Xie Xuqin , Zhao Xue , Li Ding , Deng Weijie , Song Yujiao , Shen Feng , Wu Mengchao , Wei Lixin 
Published: July 2011

AbstractOxygen deficiency and nutrient deprivation widely exists in solid tumors because of the poor blood supply. However, cancer cells can survive this adverse condition and proliferate continuously to develop. To figure out the way to survive, we investigated the role of autophagy in the microenvironment in hepatocellular carcinoma. In order to simulate the tumor microenvironment more veritably, cells were cultured in oxygen‐nutrient‐deprived condition following a hypoxia preconditioning. As a result, cell death under hypoxia plus nutrient deprivation was much less than that under nutrient deprivation only. And the decreased cell death mainly attributed to the decreased apoptosis. GFP‐LC3 and electron microscopy analysis showed that autophagy was significantly activated in the period of hypoxia preconditioning. However, autophagic inhibitor—3‐MA significantly abrogated the apoptosis reduction in hypoxia, which implied the involvement of autophagy in protection of hepatocellular carcinoma cells against apoptosis induced by starvation. Furthermore, Beclin 1 was proved to play an important role in this process. siRNA targeting Beclin 1 was transfected into hepatocellular carcinoma cells. And both data from western blot detecting the expression of LC3‐II and transmission microscopy observing the accumulation of autophagosomes showed that autophagy was inhibited obviously as a result of Beclin 1 knockdown. Besides, the decreased apoptosis of starved cells under hypoxia was reversed. Taken together, these results suggest that autophagy activated by hypoxia mediates the tolerance of hepatocellular carcinoma cells to nutrient deprivation, and this tolerance is dependent on the activity of Beclin 1. J. Cell. Biochem. 112: 3406–3420, 2011. © 2011 Wiley Periodicals, Inc.
Sphingosine kinase 1/S1P pathway involvement in the GDNF‐induced GAP43 transcription
Authors: Murakami Masashi , Ito Hiromi , Hagiwara Kazumi , Kobayashi Misa , Hoshikawa Asuka , Takagi Akira , Kojima Tetsuhito , Tamiya‐Koizumi Keiko , Sobue Sayaka , Ichihara Masatoshi , Suzuki Motoshi , Banno Yoshiko , Nozawa Yoshinori , Murate Takashi 
Published: July 2011

AbstractGlial cell line‐derived neurotrophic factor (GDNF) is important for the development and maintenance of dopamine neurons (Lin et al. [1993] Science 260: 1130–1132). GDNF is neuroprotective in animal models of Parkinson disease, where dopamine neurons show selective degeneration. We previously reported GDNF‐induced SPHK1 gene expression in a neuroblastoma cell line, TGW (Murakami et al. [2007] J Neurochem 102: 1585–1594). In the present study, we focused on the regulatory mechanism of GAP43 (GDNF‐induced neuronal phenotype) transcription to further elucidate physiological roles of GDNF‐induced SPHK1 expression and activity. Stable wild‐type (SPHK1‐WT) but not dominant‐negative SPHK1 (SPHK1‐DN) overexpression increased both control‐ and GDNF‐induced GAP43 expression. SPHK1‐WT cells showed enhanced GDNF‐induced sphingosine 1‐phosphate (S1P) secretion compared with mock‐ and SPHK1‐DN cells. Exogenous S1P also increased GAP43 expression. In TGW cells, PD98059, a MEK inhibitor, but not SB203580 (a p38 MAPK inhibitor) and LY294002 (a PI3K inhibitor) inhibited GDNF‐induced GAP43 expression, suggesting the MEK/ERK pathway has a major role in GDNF‐induced GAP43 transcription. A G‐protein‐coupled receptor inhibitor, pertussis toxin, and S1P1 and S1P3 receptor antagonists (VPC23019 and CAY10444) also inhibited ERK activation. Moreover, both S1P1 and S1P3 were serine‐phosphorylated by GDNF, suggesting their activated states. C/EBPβ transcription factor was induced by GDNF, and DNA pull‐down and chromatin immunoprecipitation assays revealed the C/EBP binding site between −131 bp and −98 bp from the first exon of GAP43. Taken together, our results showed that in TGW cells, GDNF increased SPHK1 transcription, leading to the production and secretion of S1P. Through MEK/ERK pathway, S1P stimulates GAP43 transcription with increased binding of C/EBPβ to the 5′‐promoter. J. Cell. Biochem. 112: 3449–3458, 2011. © 2011 Wiley Periodicals, Inc.
Saitohin, which is nested within the tau gene, interacts with tau and Abl and its human‐specific allele influences Abl phosphorylation
Authors: Wang Yan , Gao Lei , Conrad Christopher G. , Andreadis Athena 
Published: July 2011

AbstractSaitohin (STH) is a gene unique to humans and their closest relatives whose function is not yet known. STH contains a single polymorphism (Q7R); the Q allele is human‐specific and confers susceptibility to several neurodegenerative diseases. In previous work, we discovered that STH interacts with Peroxiredoxin 6 (Prdx6), a unique member of that family which is bifunctional and whose levels increase in Pick's disease. In this study, we report that STH also interacts with tau and the non‐receptor tyrosine kinase c‐Abl (Abl). Furthermore, Abl phosphorylates STH on its single tyrosine residue and STH increases tyrosine phosphorylation by Abl. The effect of Saitohin on Abl‐mediated phosphorylation appears to be allele‐specific, providing evidence for a new cellular function for STH. J. Cell. Biochem. 112: 3482–3488, 2011. © 2011 Wiley Periodicals, Inc.
Tissue transglutaminase promotes PDGF/PDGFR‐mediated signaling and responses in vascular smooth muscle cells
Authors: Zemskov Evgeny A. , Mikhailenko Irina , Smith Elizabeth P. , Belkin Alexey M. 
Published: July 2011

AbstractAlthough the pivotal role of platelet derived growth factor (PDGF)‐mediated signaling in vascular diseases was demonstrated, the pathophysiological mechanisms driving its over‐activation remain incompletely understood. Tissue transglutaminase (tTG) is a multifunctional protein expressed in the vasculature, including smooth muscle cells (SMCs), and implicated in several vascular pathologies. The goal of this study is to define the regulation of PDGF‐BB/PDGFRβ‐induced signaling pathways and cell responses by tTG in vascular SMCs. We find that in human aortic SMCs, shRNA‐mediated depletion and over‐expression of tTG reveals its ability to down‐regulate PDGFRβ levels and induce receptor clustering. In these cells, tTG specifically amplifies the activation of PDGFRβ and its multiple downstream signaling targets in response to PDGF‐BB. Furthermore, tTG promotes dedifferentiation and increases survival, proliferation, and migration of human aortic SMCs mediated by this growth factor. Finally, PDGF‐BB stimulates tTG expression in human aortic SMCs in culture and in the blood vessels in response to injury. Together, our results show that tTG in vascular SMCs acts as a principal enhancer within the PDGF‐BB/PDGFRβ signaling axis involved in phenotypic modulation of these cells, thereby suggesting a novel role for this protein in the progression of vascular diseases. J. Cell. Physiol. 227: 2089–2096, 2012. © 2011 Wiley Periodicals, Inc.
Spontaneous fibroblast‐derived pericyte recruitment in a human tissue‐engineered angiogenesis model in vitro
Authors: Berthod François , Symes Julie , Tremblay Nathalie , Medin Jeffrey A. , Auger François A. 
Published: July 2011

AbstractCooperation between endothelial cells and pericytes is essential to the stabilization and maturation of blood microvessels. We developed a unique in vitro tissue‐engineered model to study angiogenesis. The human endothelialized reconstructed connective tissue model promotes the formation of a three‐dimensional branching network of capillary‐like tubes (CLT) with closed lumens. The purpose of this work was to investigate whether pericytes were spontaneously recruited around CLT in the model. We demonstrated that smooth muscle α‐actin (SMA)‐positive cells were found closely associated with PECAM‐1‐positive capillaries in the model. Twelve percent (±2.6) of SMA‐positive cells were detected along with 15% (±1.64) von Willebrand factor‐positive endothelial cells in the culture system after 31 days of in vitro maturation. Conversely, no SMA‐positive cells were detected in reconstructed connective tissues made solely of fibroblasts. Knowing that PDGF is a major factor in the recruitment of pericytes, we showed that blockade of the PDGFB receptor using the inhibitor AG1296 induced an overall 5, 2.6, and 2.4‐fold decrease in the SMA‐positive cells, von Willebrand factor‐positive cells, and number of capillaries, respectively. Using combinations of human GFP‐positive fibroblasts and endothelial cells, we demonstrated that pericytes were recruited from the fibroblast population in the model. In conclusion, our tissue‐engineered culture system promotes the spontaneous formation of a network of capillaries and the recruitment of pericytes derived from fibroblasts. Since pericytes are essential components of the blood microvasculature, this culture system is a powerful model to study angiogenesis and endothelial cell/pericyte interactions in vitro. J. Cell. Physiol. 227: 2130–2137, 2012. © 2011 Wiley Periodicals, Inc.
Safety of gadolinium‐based contrast material in sickle cell disease
Authors: Dillman Jonathan R. , Ellis James H. , Cohan Richard H. , Caoili Elaine M. , Hussain Hero K. , Campbell Andrew D. , Strouse Peter J. 
Published: July 2011

AbstractPurpose:To assess the safety of intravenously administered gadolinium‐based contrast material in sickle cell disease (SCD) patients.Materials and Methods:All pediatric and adult SCD patients evaluated by magnetic resonance imaging (MRI) at our institution between January 1995 and July 2009 were identified. The medical records of SCD patients who underwent contrast‐enhanced MRI as well as an equal‐sized cohort of SCD patients who underwent unenhanced MRI were reviewed for adverse (vaso‐occlusive and hemolytic) events within 1 week following imaging.Results:Eight (five mild and three moderate) adverse events were documented within 1 week following contrast‐enhanced MRI (38 patients and 61 contrast injections), while six (five mild and one moderate) similar events occurred within 1 week following unenhanced MRI (61 patients and 61 unenhanced MRI examinations). This difference in the number of adverse events was not statistically significant (odds ratio = 1.4; 95% confidence interval [CI] 0.4, 5.2). No severe adverse event occurred in either patient cohort.Conclusion:Gadolinium‐based contrast materials do not appear to be associated with increased risk of vaso‐occlusive or hemolytic adverse events when administered to SCD patients. Larger, prospective studies using multiple gadolinium‐based contrast materials would be useful to confirm the results of our investigation. J. Magn. Reson. Imaging 2011;. © 2011 Wiley‐Liss, Inc.
Strenuous resistance exercise effects on magnetic resonance diffusion parameters and muscle–tendon function in human skeletal muscle
Authors: Yanagisawa Osamu , Kurihara Toshiyuki , Kobayashi Naoyuki , Fukubayashi Toru 
Published: July 2011

AbstractPurpose:To assess the effects of strenuous exercise on magnetic resonance diffusion parameters and muscle–tendon complex function in skeletal muscle.Materials and Methods:Six men performed ankle plantar flexion exercises with eccentric contraction. The fractional anisotropy (FA), λ1, λ2, λ3, mean diffusivity (MD), and T2 values in the triceps surae muscles were measured by magnetic resonance diffusion tensor and spin‐echo imaging. Passive torque of plantar flexors, maximal voluntary isometric plantar flexion torques (MVIP), and Achilles tendon stiffness during MVIP were measured by combined ultrasonography and dynamometry. Plasma creatine kinase and muscle soreness were also assessed. These parameters were measured before and 1–8 days postexercise.Results:The medial gastrocnemius exhibited significantly decreased FA 2–5 days after, increased λ2 3 days after, and increased λ3 2 and 3 days after exercise. This muscle also showed significantly increased MD and T2 values 3 days postexercise. MVIP significantly decreased 2 and 3 days postexercise, while passive torque significantly increased 2 days postexercise. Creatine kinase and muscle soreness increased 3–5 days and 1–5 days postexercise, respectively.Conclusion:Exercise‐induced muscle damage manifested as significant changes in muscle diffusion parameters with muscle–tendon complex dysfunction and delayed‐onset muscle soreness. J. Magn. Reson. Imaging 2011;. © 2011 Wiley‐Liss, Inc.