bluuebunny/crossref_metadata_2025_split huggingface dataset:
Victimization, polyvictimization, and depression symptoms among immigrants and native children and youth in Chile
Authors: Pinto-Cortez Cristián , Marín-Gutiérrez Mauricio , Melis-Rivera Carlos , Contreras-Taibo Lorena , Moya-Vergara Rodrigo 
Published: June 2024

Abstract
Background
Migration exposes children and youth to vulnerabilities, including uprooting, lack of protection, limited access to services, and violence. Previous studies have shown that victimization experiences impact the mental health of migrant children, including depression, anxiety, and post-traumatic stress disorder. This study aims to examine the co-occurrence of multiple forms of maltreatment (polyvictimization) among migrant and Chilean children and youth and its association with depressive symptoms, addressing a research gap in Latin America.

Methods
Secondary data from the National Polyvictimization Survey (NPS) conducted by the Chilean Ministry of the Interior were analyzed. Measures assessing polyvictimization and depressive symptoms were administered to a sample of 1362 participants, with equal group sizes for migrants and Chilean-born individuals. Data analysis included descriptive statistics, group comparisons, correlation analyses, and multiple regression analyses.

Results
The study revealed marked differences in experiences of conventional crime victimization and polyvictimization between migrant and Chilean-born participants, with migrants facing slightly higher incidences. Correlational analysis indicated variable strengths of association between victimization types and depressive symptoms across groups, with Chilean-born individuals showing stronger correlations for certain victimization forms. Multiple regression analysis highlighted gender, polyvictimization, child maltreatment, internet victimization, sexual victimization, and peer/sibling victimization as significant predictors of depressive symptoms across the sample. Notably, an interaction was observed between child maltreatment and migrant status, indicating a mitigated impact of maltreatment on depressive symptoms among migrant adolescents. This suggests the potential for unique resilience or coping mechanisms in this group.

Conclusions
This study elucidates the varied victimization experiences of migrant children and youth in Chile, with a notable emphasis on the mitigating effect of migrant status on the relationship between child maltreatment and depressive symptoms. It highlights the resilience and potential adaptive strategies of migrant minors facing adversity. The findings underscore the necessity of developing support and intervention strategies that recognize the specific needs and strengths of migrant children and youth, advocating for policies that protect and empower this vulnerable demographic amidst new environmental challenges.
TFAP2A downregulation mediates tumor-suppressive effect of miR-8072 in triple-negative breast cancer via inhibiting SNAI1 transcription
Authors: Fang Yujie , Wang Yali , Ma Hongning , Guo Yuqi , Xu Rongrong , Chen Xixi , Chen Xuehua , Lv Ye , Li Pu , Gao Yujing 
Published: June 2024

Abstract
Background
Triple-negative breast cancer (TNBC) represents a highly aggressive subset of breast malignancies characterized by its challenging clinical management and unfavorable prognosis. While TFAP2A, a member of the AP-2 transcription factor family, has been implicated in maintaining the basal phenotype of breast cancer, its precise regulatory role in TNBC remains undefined.

Methods
In vitro assessments of TNBC cell growth and migratory potential were conducted using MTS, colony formation, and EdU assays. Quantitative PCR was employed to analyze mRNA expression levels, while Western blot was utilized to evaluate protein expression and phosphorylation status of AKT and ERK. The post-transcriptional regulation of TFAP2A by miR-8072 and the transcriptional activation of SNAI1 by TFAP2A were investigated through luciferase reporter assays. A xenograft mouse model was employed to assess the in vivo growth capacity of TNBC cells.

Results
Selective silencing of TFAP2A significantly impeded the proliferation and migration of TNBC cells, with elevated TFAP2A expression observed in breast cancer tissues. Notably, TNBC patients exhibiting heightened TFAP2A levels experienced abbreviated overall survival. Mechanistically, TFAP2A was identified as a transcriptional activator of SNAI1, a crucial regulator of epithelial-mesenchymal transition (EMT) and cellular proliferation, thereby augmenting the oncogenic properties of TFAP2A in TNBC. Moreover, miR-8072 was unveiled as a negative regulator of TFAP2A, exerting potent inhibitory effects on TNBC cell growth and migration. Importantly, the tumor-suppressive actions mediated by the miR-8072/TFAP2A axis were intricately associated with the attenuation of AKT/ERK signaling cascades and the blockade of EMT processes.

Conclusions
Our findings unravel the role and underlying molecular mechanism of TFAP2A in driving tumorigenesis of TNBC. Targeting the TFAP2A/SNAI1 pathway and utilizing miR-8072 as a suppressor represent promising therapeutic strategies for treating TNBC.
Rituximab in the treatment of progressive interstitial lung disease associated with the antisynthetase syndrome
Authors: Narváez Javier , Cañadillas Elena , Castellví Iván , Alegre Juan José , Vicens-Zygmunt Vanesa , Bermudo Guadalupe , Vidal-Montal Paola , Molina Molina María , Nolla Joan Miquel 
Published: June 2024

Abstract
Objective
To assess the real-world, long-term effectiveness of rituximab (RTX) as a rescue therapy in patients with antisynthetase syndrome and progressive interstitial lung disease (ASS-ILD).

Methods
Multicentre observational retrospective longitudinal study of a cohort of patients with ASS-ILD that started treatment with RTX due to recurrent or ongoing progressive ILD despite therapy with glucocorticoids and immunosuppressants.

Results
Twenty-eight patients were analyzed. Examining the entire study population, before treatment with RTX the mean decline in %pFVC and %pDLCO from the ASS-ILD diagnosis to the initiation of RTX treatment (T0) was -6.44% and -14.85%, respectively. After six months of treatment, RTX reversed the decline in pulmonary function test (PFT) parameters: ∆%pFVC +6.29% (95% CI: -10.07 to 2.51; p=0.002 compared to T0) and ∆%pDLCO +6.15% (95% CI: -10.86 to -1.43; p=0.013).
Twenty-four patients completed one year of therapy and 22 two years, maintaining the response in PFT: ∆%pFVC: +9.93% (95% CI: -15.61 to -4.25; p=0.002) and ∆%pDLCO: +7.66% (95% CI: -11.67 to -3.65; p<0.001). In addition, there was a significant reduction in the median dose of prednisone, and it could be suspended in 18% of cases. In 33% of patients who required oxygen therapy at the start of treatment, it could be discontinued.
The frequency of adverse events reached 28.5% of cases.

Conclusion
Based on our results, RTX appears to be effective as rescue therapy in most patients with recurrent or progressive ASS-ILD unresponsive to conventional treatment. The use of RTX was well tolerated in the majority of patients.
Association of institutional masking policies with healthcare-associated SARS-CoV-2 infections in Swiss acute care hospitals during the BA.4/5 wave (CH-SUR study): a retrospective observational study
Authors: Dörr Tamara , Güsewell Sabine , Flury Domenica , Süveges Maria , Gaza Valera Camille Beatrice , Botero-Mesa Sara , Zanella Marie-Céline , Iten Anne , Balmelli Carlo , Troillet Nicolas , Tschudin-Sutter Sarah , W Schreiber Peter , Jent Philipp , Damonti Lauro , Sommerstein Rami , Portmann Lea , Vuichard-Gysin Danielle , Cusini Alexia , Nussbaumer-Ochsner Yvonne , Heininger Ulrich , Berger Christoph , Zimmermann Petra , Gardiol Céline , Keiser Olivia , Schlegel Matthias , Kohler Philipp , P Kuster Stefan 
Published: June 2024

Abstract
Background
In the initial phase of the SARS-CoV-2 pandemic, masking has been widely accepted in healthcare institutions to mitigate the risk of healthcare-associated infection. Evidence, however, is still scant and the role of masks in preventing healthcare-associated SARS-CoV-2 acquisition remains unclear.We investigated the association of variation in institutional mask policies with healthcare-associated SARS-CoV-2 infections in acute care hospitals in Switzerland during the BA.4/5 2022 wave.

Methods
SARS-CoV-2 infections in hospitalized patients between June 1 and September 5, 2022, were obtained from the “Hospital-based surveillance of COVID-19 in Switzerland”-database and classified as healthcare- or community-associated based on time of disease onset. Institutions provided information regarding institutional masking policies for healthcare workers and other prevention policies. The percentage of healthcare-associated SARS-CoV-2 infections was calculated per institution and per type of mask policy. The association of healthcare-associated SARS-CoV-2 infections with mask policies was tested using a negative binominal mixed-effect model.

Results
We included 2’980 SARS-CoV-2 infections from 13 institutions, 444 (15%) were classified as healthcare-associated. Between June 20 and June 30, 2022, six (46%) institutions switched to a more stringent mask policy. The percentage of healthcare-associated infections subsequently declined in institutions with policy switch but not in the others. In particular, the switch from situative masking (standard precautions) to general masking of HCW in contact with patients was followed by a strong reduction of healthcare-associated infections (rate ratio 0.39, 95% CI 0.30–0.49). In contrast, when compared across hospitals, the percentage of health-care associated infections was not related to mask policies.

Conclusions
Our findings suggest switching to a more stringent mask policy may be beneficial during increases of healthcare-associated SARS-CoV-2 infections at an institutional level.
Analysing the impacts of a reform on harmful fishery subsidies in Spain using a social accounting matrix
Authors: Roca Florido Alberto , Padilla Rosa Emilio 
Published: June 2024

AbstractThe effects of discontinuing harmful fishery subsidies in Spain were analysed using a social accounting matrix. The study found that the removal of these subsidies would have negative consequences for the economy. Specifically, there would be a significant decline in the production value of marine resource industries, and industries dependent on fish and shellfish as inputs would experience increased production costs. The exports, mainly to EU countries, would also be impacted, and certain marine resource sectors would experience significant job losses. Fishing families would suffer the greatest reduction in income once subsidies are removed. However, there is potential to mitigate most of the negative impacts by redirecting the removed subsidies, as it is shown for the case of their redirection to research and development industries. The findings of this study provide valuable insights for EU policymakers in implementing specific policies to address the potential consequences on affected sectors, families, and employers as part of the next European strategy, Horizon 2021–2027.
The double-edged effects of IL-6 in liver regeneration, aging, inflammation, and diseases
Authors: Wang Min-Jun , Zhang Hai-Ling , Chen Fei , Guo Xiao-Jing , Liu Qing-Gui , Hou Jin 
Published: June 2024

AbstractInterleukin-6 (IL-6) is a pleiotropic cytokine and exerts its complex biological functions mainly through three different signal modes, calledcis-,trans-, and cluster signaling. When IL-6 binds to its membrane or soluble receptors, the co-receptor gp130 is activated to initiate downstream signaling and induce the expression of target genes. In the liver, IL-6 can perform its anti-inflammatory activities to promote hepatocyte reprogramming and liver regeneration. On the contrary, IL-6 also exerts the pro-inflammatory functions to induce liver aging, fibrosis, steatosis, and carcinogenesis. However, understanding the roles and underlying mechanisms of IL-6 in liver physiological and pathological processes is still an ongoing process. So far, therapeutic agents against IL‑6, IL‑6 receptor (IL‑6R), IL-6-sIL-6R complex, or IL-6 downstream signal transducers have been developed, and determined to be effective in the intervention of inflammatory diseases and cancers. In this review, we summarized and highlighted the understanding of the double-edged effects of IL-6 in liver homeostasis, aging, inflammation, and chronic diseases, for better shifting the “negative” functions of IL-6 to the “beneficial” actions, and further discussed the potential therapeutic effects of targeting IL-6 signaling in the clinics.
Psychological wellbeing with music therapy: the moderating role of health awareness, and strategic health management in post Covid-19 era
Authors: Liu Yang 
Published: June 2024

Abstract
Background
Psychological problems are common among the people of every community. These psychological issues are leading people to mental health issues. Human well-being is required to be improved appropriately for the better health of the public. The objective of this research is to determine the influence of music therapy on the sustainable psychological well-being of the Chinese community. Furthermore, this research determines that moderating role of health awareness and strategic health management between music therapy and sustainable psychological well-being.

Method
The research used a sample of 384 collected with a random sampling method. For data collection, a cross-sectional method was adopted to collect data on a Likert scale questionnaire. The Health Awareness Scale, Music Therapy Scale, Sustainable Health Management Scale and Sustainable Psychological Wellbeing Scale was used in this research.

Results
The findings of the research highlighted that there is a significant and positive influence of music therapy on the sustainable psychological well-being of the Chinese community. This research also concluded that there is a significant and positive moderating role of health awareness and strategic health management between music therapy and sustainable psychological well-being. The findings of this research are new and novel in the literature on psychological well-being.

Conclusion
This research has some theoretical and practical implications to advance the literature and practice for sustainable psychological well-being respectively. In clinical practice, music therapy can be effectively used to improve the psychological well-being of individuals with sustainability. The information related to health awareness and practice for strategic health management is also necessary for the clinical patients to improve their psychological well-being.
A grounded theory-based model of information communication in cultural heritage digital reading on the social media from the perspective of the embodied theory
Authors: Zhang Jingwen , Xu Chenyu 
Published: June 2024

Abstract
New media technologies have opened up new possibilities for the communication of cultural heritage, and digital reading aligns with the participatory shift in museums, becoming an indispensable part of information communication. Currently, there exists a certain contradiction between the professional content of cultural heritage and the non-linear and immersive narrative style of new media. In order to find a balance between form and content, and explore the information communication pattern of cultural heritage in the era of mobile media, starting from practical issues, this article introduces the theory of embodied cognition, combines it with relevant theories in communication studies, and systematically explores the impact of embodied factors on audience reading behavior by using semi-structured interviews and grounded theory. The research reveals that embodied cognition, situational cognition, and interactive cognition have a significant impact on the digital reading information communication of cultural heritage on social media, which includes six factors: functional experience, sensory experience, interactive experience, scene simulation, emotional elevation and social experience. This study further constructed a theoretical model of the factors influencing the effectiveness of information communication in cultural heritage digital reading on the social media platform under the influence of embodied cognition theory, which confirms that these six factors play a significant role in the process of museum content generation, audience understanding, as well as the emergence of and the feedback loop of new meanings.
Exploring the viability of Bentonite-amended blends incorporating marble dust, sand, and fly ash for the creation of an environmentally sustainable landfill liner system
Authors: Jain Ankush Kumar 
Published: June 2024

AbstractThe development of effective and cost-efficient landfill liners is crucial to prevent groundwater contamination from leachate, safeguarding soil quality and the environment. Composite liners, particularly those combining bentonite with supplementary materials such as fly ash or marble dust, present a promising solution. This study delves into a comprehensive investigation of the physical properties of landfill liners composed of bentonite-fly ash and bentonite-marble dust mixtures through an extensive series of laboratory tests. The research systematically analyzes various proportions of bentonite with fly ash and marble dust, evaluating their impact on liner performance in comparison to Bentonite-sand mixtures. Physicochemical analyses are employed to understand the interactions and behaviors of these distinct substances within the amended bentonite. A wide array of physical properties, including Atterberg’s limits, compaction characteristics, free swell index, modified free swell index, California bearing ratio, cohesion, and angle of internal friction, are meticulously examined. Collectively, these properties offer a comprehensive overview of the suitability and performance potential of bentonite-fly ash and bentonite-marble dust mixtures as landfill liners, presenting a viable alternative to traditional bentonite-sand mixtures. The study reveals synergistic effects between bentonite and both fly ash and marble dust, highlighting their significant contributions to enhancing the physical traits of landfill liners. This advancement in landfill liner design holds the promise of effectively mitigating detrimental environmental impacts associated with waste disposal. While this study provides a robust foundation, it is essential for future investigations to prioritize long-term performance assessments and real-world implementation. Validation and fine-tuning of these findings are crucial to ensuring practical applicability and efficacy within authentic landfill construction scenarios. This holistic approach will contribute to the continued evolution and optimization of landfill liner design, addressing the pressing challenges of sustainable waste management and environmental protection.
Randomized Phase III Study of Amcenestrant Plus Palbociclib Versus Letrozole Plus Palbociclib in Estrogen Receptor–Positive, Human Epidermal Growth Factor Receptor 2–Negative Advanced Breast Cancer: Primary Results From AMEERA-5
Authors: Cortés Javier , Hurvitz Sara A. , O'Shaughnessy Joyce , Delaloge Suzette , Iwata Hiroji , Rugo Hope S. , Neven Patrick , Kanagavel Dheepak , Cohen Patrick , Paux Gautier , Cartot-Cotton Sylvaine , Stefanova-Urena Maya , Deyme Laure , Aouni Jihane , Sebastien Bernard , Bardia Aditya 
Published: June 2024

PURPOSE AMEERA-5 investigated amcenestrant (oral selective estrogen receptor [ER] degrader) plus palbociclib versus letrozole plus palbociclib as first-line treatment for ER-positive/human epidermal growth factor receptor 2–negative (ER+/HER2–) advanced/metastatic breast cancer (aBC). MATERIALS AND METHODS In AMEERA-5 (ClinicalTrials.gov identifier: NCT04478266 ), a double-blind, double-dummy, international phase III trial, adult pre-/post-menopausal women and men without previous systemic therapy for ER+/HER2– aBC were randomly assigned 1:1 to amcenestrant 200 mg once daily + standard palbociclib dosage (125 mg once daily, 21 days on/7 days off) or letrozole 2.5 mg once daily + standard palbociclib dosage, stratified by de novo metastatic disease, postmenopausal women, and visceral metastasis. The primary end point was progression-free survival (PFS), compared using a stratified log-rank test with one-sided type I error rate of 2.5%. Secondary end points included overall survival (key secondary), pharmacokinetics, and safety. RESULTS Between October 14, 2020, and December 2, 2021, 1,068 patients were randomly assigned to amcenestrant + palbociclib (N = 534) or letrozole + palbociclib (N = 534). At the interim analysis (median follow-up 8.4 months), the stratified hazard ratio for PFS was 1.209 (95% CI, 0.939 to 1.557; one-sided P value = .9304); therefore, the study was stopped for futility. The 6-month PFS rate was 82.7% (95% CI, 79.0 to 85.8) with amcenestrant + palbociclib versus 86.9% (95% CI, 83.5 to 89.6) with letrozole + palbociclib. In the amcenestrant + palbociclib versus letrozole + palbociclib groups, treatment-emergent adverse events (any grade) occurred in 85.6% versus 85.4% of patients and grade ≥3 events in 46.3% versus 60.8%, respectively. CONCLUSION The AMEERA-5 study was discontinued on the basis of the recommendation of the data monitoring committee at the interim futility analysis. No new safety signals were identified.
Double CYP11B1/CYP11B2 Immunohistochemistry and Detection of KCNJ5 Mutations in Primary Aldosteronism
Authors: Caroccia Brasilina , Lenzini Livia , Ceolotto Giulio , Gioco Francesca , Benetti Andrea , Giannella Alessandra , Ajjour Hala , Galuppini Francesca , Pennelli Gianmaria , Seccia Teresa Maria , Gomez-Sanchez Celso , Rossi Gian Paolo 
Published: June 2024

Abstract

Context
The search for somatic mutations in adrenals resected from patients with primary aldosteronism (PA) is performed by Sanger sequencing, often implemented with immunohistochemistry (IHC)-guidance focused on aldosterone-producing (CYP11B2-positive) areas.

Objective
To investigate the impact of double IHC for CYP11B1 and CYP11B2 on Sanger and next-generation sequencing (NGS).

Methods
We investigated 127 consecutive adrenal aldosterone-producing adenomas from consenting surgically cured PA patients using double IHC for CYP11B1 and CYP11B2, by Sanger sequencing and NGS.

Results
Double IHC for CYP11B2 and CYP11B1 revealed 3 distinct patterns: CYP11B2-positive adenoma (pattern 1), mixed CYP11B1/CYP11B2-positive adenoma (pattern 2), and adrenals with multiple small CYP11B2-positive nodules (pattern 3). Sanger sequencing allowed detection of KCNJ5 mutations in 44% of the adrenals; NGS revealed such mutations in 10% of those negative at Sanger and additional mutations in 61% of the cases. Importantly the rate of KCNJ5 mutations differed across patterns: 17.8% in pattern 1, 71.4% in pattern 2, and 10.7% in pattern 3 (χ2 = 22.492, P &lt; .001).

Conclusion
NGS allowed detection of mutations in many adrenals that tested negative at Sanger sequencing. Moreover, the different distribution of KCNJ5 mutations across IHC patterns indicates that IHC-guided sequencing protocols selecting CYP11B2-positive areas could furnish results that might not be representative of the entire mutational status of the excised adrenal, which is important at a time when KCNJ5 mutations are suggested to drive management of patients with aldosterone-producing adenomas.