bluuebunny/crossref_metadata_2025_split huggingface dataset:
A search for novel markers of alcohol abuse using magnetic beads and MALDI‐TOF/TOF mass spectrometry
Authors: Sogawa Kazuyuki , Satoh Mamoru , Kodera Yoshio , Tomonaga Takeshi , Iyo Masaomi , Nomura Fumio 
Published: July 2009

AbstractObjective markers are required to assess excessive alcohol consumption, which can lead to a various medical and social problems. In this study, we carried out serum peptidome analyses using the ClinProt™ system, which consists of magnetic beads and MALDI‐TOF/TOF MS, to find novel biomarkers of alcohol abuse in 16 chronic alcoholic patients that were hospitalized for a rehabilitation program. A total of 22 peaks were found to be significantly altered during abstinence. Out of these 22 peaks, 3 peaks that had an m/z of 3000 or less and substantial peak intensities were subjected to MS/MS analysis followed by a MASCOT search. The 1466 Da and the 1616 Da peptides were upregulated on admission and were identified as fragments of fibrinopeptide A and phosphorylated fibrinopeptide A, respectively. On the other hand, the 2660 Da peptide, which was downregulated on admission and increased during abstinence, was identified as a fragment of the fibrinogen α C chain. These peaks were not detectable by the SELDI‐TOF MS ProteinChip® system analysis. The alterations in these peaks induced by alcohol abuse were also seen in γ glutamyltransferase nonresponders. These protein fragments may be additional biomarkers for excessive alcohol drinking.
Effects of CXCR4 antagonist CTCE‐9908 on prostate tumor growth
Authors: Porvasnik Stacy , Sakamoto Noboru , Kusmartsev Sergei , Eruslanov Evgeniy , Kim Wan‐Ju , Cao Wengang , Urbanek Cydney , Wong Donald , Goodison Steve , Rosser Charles J. 
Published: July 2009

AbstractBACKGROUNDRecent reports have linked the survival‐promoting effect of CXCR4 to the up regulation of Bcl‐2 protein expression.MATERIALS AND METHODSTo further elucidate the relationship between Bcl‐2 and CXCR4, tumorigenicity was evaluated in in vitro and in vivo models following treatment with CTCE‐9908, a CXCR4 antagonist peptide.RESULTSIn vitro, CTCE‐9908 inhibited cellular proliferation in PC‐3‐Bcl‐2 and PC‐3‐Neo cell lines Furthermore in our xenograft model, CTCE‐9908 delivered via daily intraperitoneal injections resulted in a statistically significant reduction in tumor size compared to control (396 + 205 mm3 vs. 1,010 + 215 mm3 respectively, p < 0.05) in the Bcl‐2 expressing tumors. This reduction was associated with knockdown of VEGF, inhibition of angiogenesis and lymphangiogenesis, and induction of apoptosis. CTCE‐9908 therapy was also associated with a marked reduction in intra‐tumoral host cells expressing VEGFR1 and CD11b myeloid‐derived suppressor cells (MDSC).CONCLUSIONThese data show that CXCR4 antagonists represent a valuable addition to the cancer therapeutic arsenal. Such agents may have beneficial synergistic dual‐effects in reducing tumor cell proliferation directly, and indirectly through perturbation of the tumor microenvironment. Further studies of the novel CTCE‐9908 compound in prostate and other solid tumor inhibition are warranted. Prostate 69: 1460–1469, 2009. © 2009 Wiley‐Liss, Inc.
Preliminary evaluation of the effect of dutasteride on PCA3 in post‐DRE urine sediments: A randomized, open‐label, parallel‐group pilot study
Authors: van Gils Martijn P.M.Q. , Hessels Daphne , Peelen W. Pim , Vergunst Henk , Mulders Peter F.A. , Schalken Jack A. 
Published: July 2009

AbstractBACKGROUNDDutasteride is commonly used in patients that are also at risk for prostate cancer (PCa). Therefore, the influence of dutasteride on PCa markers has to be studied. To date, only the effect of dutasteride on serum prostate‐specific antigen (PSA) has been studied. This was the first study to investigate the effect of dutasteride on the new PCa marker PCA3, longitudinally and in a dose dependent manner.METHODSFrom April 25, 2005 to October 31, 2006, 16 subjects with benign prostatic hyperplasia (BPH) and 9 subjects with clinically localized PCa were enrolled at the urological outpatient clinics of one university hospital and one community hospital. Eight subjects with BPH and five with PCa received 0.5 mg dutasteride once daily for 3 months, eight with BPH and four with PCa received 3.5 mg. No subjects were withdrawn because of adverse effects.RESULTSIn all four groups both 0.5 and 3.5 mg dutasteride had a variable effect on the PCA3 score. In contrast, its other effects were consistent as it rapidly reduced serum DHT by ≥90%, over time increased serum T by 20–30%, over time halved serum PSA and decreased prostate volume by 10–16%.CONCLUSIONSIn this exploratory/pilot study the effect of dutasteride on the PCA3 score was variable. This should be taken into account while using PCA3 in diagnostics. As this study was exploratory, the influence of androgen‐deprivation therapy on the PCA3 score should be analyzed further. Prostate 69: 1624–1634, 2009. © 2009 Wiley‐Liss, Inc.
Thermal behaviour and biological activity against Aedes aegypti (Diptera: Culicidae) of permethrin and pyriproxyfen in a smoke‐generating formulation
Authors: Harburguer Laura V , Seccacini Emilia , Masuh Héctor , González Audino Paola , Zerba Eduardo , Licastro Susana 
Published: July 2009

AbstractBACKGROUND: The most common ways to control dengue vector Aedes aegypti (L.) are larval source reduction in domestic habitats and ground application of small quantities of aerosol insecticide (ultralow volume). Nevertheless, these actions have been shown repeatedly to be ineffective in controlling Ae. aegypti populations.RESULTS: The efficacy of a new smoke‐generating formulation containing pyriproxyfen and permethrin was evaluated in the laboratory. Smoke‐generating tablets containing each insecticide individually or combined were prepared, and the recovery of the insecticides from the smoke was determined. Recovery values of over 90% were obtained for pyriproxyfen, and around 50% for permethrin. The biological efficacy of pyriproxyfen released in the smoke was evaluated in the laboratory, on late third‐instar or early fourth‐instar Ae. aegypti larvae, using different concentrations of pyriproxyfen and exposure times. Adult emergence inhibition (EI) values of 100% were obtained at 30 min, and a dose‐dependent effect was observed at 5 min. The effect of pyriproxyfen released in the smoke was due to direct contact with the larvicide in the water rather than by inhalation of the fumes. The efficacy of permethrin released in the fumes was also evaluated as knockdown effect (KT50) on adults for a tablet containing permethrin alone or permethrin plus pyriproxyfen. There was no significant difference in KT50 values obtained for permethrin (KT50 = 19.9 min) and permethrin plus pyriproxyfen (KT50 = 19.4 min).CONCLUSION: The excellent laboratory performance of this new formulation on immature stages and adults indicates that a smoke‐generating tablet containing pyriproxyfen and permethrin could be a new tool for controlling mosquitoes. Copyright © 2009 Society of Chemical Industry
Phonon spectra of quaternary Cd1–yZny S1–xSex semiconductor nanocrystals grown in a glass matrix
Authors: Azhniuk Yu. M. , Milekhin A. G. , Gomonnai A. V. , Hutych Yu. I. , Lopushansky V. V. , Zahn D. R. T. 
Published: July 2009

AbstractQuaternary Cd1–y Zny S1–x Sex nanocrystals are obtained in a borosilicate glass matrix by solid‐state precipitation at temperatures within 625 to 700 °C. Raman spectroscopy is applied to determine the nanocrystal composition and to show its dependence on the heat treatment temperature and duration. Diffusion‐induced migration of Zn ions from the matrix to the NCs results in its content increase up to ∼20% at the heat treatment; meanwhile for Se‐rich NCs an increase of Se content is also observed. (© 2009 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Surface phonons in CdS1–xSex nanoparticles embedded in a dielectric medium
Authors: Azhniuk Yu. M. , Hutych Yu. I. , Lopushansky V. V. , Milekhin A. G. , Gomonnai A. V. , Zahn D. R. T. 
Published: July 2009

AbstractRaman scattering by surface phonons in CdS1–x Sex nanocrystals grown in a borosilicate glass matrix, is studied. CdSe‐like and CdS‐like surface phonon frequencies are shown to increase with the relevant component content in the nanocrystal composition. No clear size dependence of the surface phonon frequencies has been observed. On the other hand, surface phonons in CdS1–x Sex nanocrystals exhibit resonant dependence on the Raman excitation wavelength. It is emphasized that measurements of Raman scattering by surface phonons in CdS1–x Sex nanocrystals give no reason to judge upon the nanocrystal shape. (© 2009 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Resonant Raman spectroscopy of confined and surface phonons in CdSe‐capped CdS nanoparticles
Authors: Dzhagan Volodymyr , Rayevskaya Olexandra , Stroyuk Olexandr , Kuchmiy Stepan , Zahn Dietrich R. T. 
Published: July 2009

AbstractA series of colloidal CdS/CdSe heteronanoparticles are studied by Resonant Raman spectroscopy. The Raman‐active phonons of both CdS‐core and CdSe‐shell are monitored upon a gradual increase of the shell thickness. Noticeable differences between the Raman spectra taken at different excitation wavelengths are observed, which can be related to different resonant conditions for different vibrational modes at a certain excitation wavelength. The possible morphology transformation of the CdSe shell with increase of its thickness is discussed, based on the correlation between changes in phonon spectra of the nanoparticles and the spectra of photoluminescence and optical absorption. (© 2009 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Quantum tunneling through moving Kondo objects
Authors: Kikoin Konstantin , Kiselev Michael N. , Richert Jean 
Published: July 2009

AbstractWe show how the time‐dependent modulation of charge input signal applied to the gate electrode in a double quantum dot may be converted to a pulse in the Kondo tunneling current, which is predominantly spin response of this nano‐device in a strong Coulomb blockade regime. The stochastic component of the input signal reveals itself as the infrared cutoff of Kondo tunneling transmission (© 2009 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Phononic crystals and manipulation of sound
Authors: Pennec Yan , Djafari‐Rouhani Bahram , Larabi Hocine , Vasseur Jérôme , Hladky‐Hennion Anne‐Christine 
Published: July 2009

AbstractThe acoustic properties of phononic crystals are presented, using numerical simulations. In a first part we study some possible applications of these composite materials. In particular, we show that defect modes (cavities, wave guides, stubs...) inserted inside the 2D periodic structure may lead to the possibility of manipulating the propagation of sound and realizing selective frequency filters and efficient devices for wavelength demultiplexing. We also report on the vibration modes of a 2D plate, i.e. a phononic crystal of finite thickness along the axis of the inclusions. We investigate the existence of absolute band gaps in the band structure of the plate, either free or deposited on a substrate. This should open new perspectives in the field of high‐frequency radiofrequency devices. Finally, we present the possibility of devicing sonic insulators for frequencies of the order of kHz with relatively small thicknesses of the phononic crystal sample as compared to the wavelength. (© 2009 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Additional phonon modes related to intrinsic defects in CdHgTe
Authors: Polit J. , Sheregii E. M. , Cebulski J. , Kisiel A. , Marcelli A. , Robouch B. V. , Guidi M. Cestelli , Piccinini M. , Mycielski A. 
Published: July 2009

AbstractThe optical reflectivity measurements data are reported. They were obtained by means of synchrotron (DAFNE‐LIGHT in LNF, Italy) as the radiation source as well as mercury lamp, in far infrared region for the 9 sample of Hg1‐xCdxTe (x = 0.06‐0.7) in the temperature interval 20 K‐293 K. The imaginary part of dielectric function obtained by means of Kramers‐Kroning transformation were analyzed in the Lorentzian‐approximation of dielectric function, using the model of deformed tetrahedra. Beside eight canonical phonon modes observed earlier by Kozyrev et al., we observed several additional lines in the region below 120 cm–1. Our analysis is based on the experimental data obtained for the samples of n ‐ and p ‐type and prepared by different manufacture technologies. The temperature dependence of the frequency of vibration modes in the region 90 cm–1–118 cm–1 is also presented and discussed. This analysis has shown that two kinds of lines are observed in this region: the lines of the first type are generated by the electron transitions while the lines of the second one are generated by oscillations in defect‐bearing tetrahedra. (© 2009 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Extended van Hove singularity, strong electron–phonon interaction and superconducting gap in doped Bi‐2212 single crystals
Authors: Ponomarev Yaroslav , Mikheev Mikhail , Sudakova Marina , Tchesnokov Sergei , Kuzmichev Svetoslav 
Published: July 2009

AbstractTunneling spectroscopy studies of high‐temperature superconductors (HTSC) are overviewed. Facts are presented evidencing the strong electron–phonon interaction and the scaling of a superconducting gap and a critical temperature in doped Bi‐2212 single crystals. A sharp extra structure in the current‐voltage characteristics (CVC's) of Bi‐2212 contacts is attributed to the presence of the extended van Hove singularity (EVHS) close to the Fermi level in slightly overdoped and slightly underdoped samples. (© 2009 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
The correlated and shared gamma frailty model for bivariate current status data: An illustration for cross‐sectional serological data
Authors: Hens N. , Wienke A. , Aerts M. , Molenberghs G. 
Published: July 2009

AbstractFrailty models are often used to study the individual heterogeneity in multivariate survival analysis. Whereas the shared frailty model is widely applied, the correlated frailty model has gained attention because it elevates the restriction of unobserved factors to act similar within clusters. Estimating frailty models is not straightforward due to various types of censoring. In this paper, we study the behavior of the bivariate‐correlated gamma frailty model for type I interval‐censored data, better known as current status data. We show that applying a shared rather than a correlated frailty model to cross‐sectionally collected serological data on hepatitis A and B leads to biased estimates for the baseline hazard and variance parameters. Copyright © 2009 John Wiley & Sons, Ltd.
Colorimetric Protein Sensing by Controlled Assembly of Gold Nanoparticles Functionalized with Synthetic Receptors
Authors: Aili Daniel , Selegård Robert , Baltzer Lars , Enander Karin , Liedberg Bo 
Published: July 2009

AbstractA novel strategy is described for the colorimetric sensing of proteins, based on polypeptide‐functionalized gold nanoparticles. Recognition is accomplished using a polypeptide sensor scaffold designed to specifically bind to the model analyte, human carbonic anhydrase II (HCAII). The extent of particle aggregation, induced by the Zn2+‐triggered dimerization and folding of a second polypeptide also present on the surface of the gold nanoparticle, gives a readily detectable colorimetric shift that is dependent on the concentration of the target protein. In the absence of HCAII, particle aggregation results in a major redshift of the plasmon peak, whereas analyte binding prevented the formation of dense aggregates, significantly reducing the magnitude of the redshift. The versatility of the technique is demonstrated using a second model system based on the recognition of a peptide sequence from the tobacco mosaic virus coat protein (TMVP) by a recombinant antibody fragment (Fab57P). Concentrations down to ≈10 nM and ≈25 nM are detected for HCAII and Fab57P, respectively. This strategy is proposed as a generic platform for robust and specific protein analysis that can be further developed to monitor a wide range of target proteins.
Fibroblastic Colony-Forming Unit Bone Marrow Cells Delay Progression to Gastric Dysplasia in aHelicobacterModel of Gastric Tumorigenesis
Authors: Wang Sophie S.W. , Asfaha Samuel , Okumura Tomoyuki , Betz Kelly S. , Muthupalani Sureshkumar , Rogers Arlin B. , Tu Shuiping , Takaishi Shigeo , Jin Guangchun , Yang Xiangdong , Wu Deng-Chyang , Fox James G. , Wang Timothy C. 
Published: July 2009

AbstractBone marrow mesenchymal stem cells (MSCs) have been shown to have immune modulatory effects. Despite efforts to identify these cells in vivo, to date, MSCs have been defined mainly by their in vitro cell characteristics. Here, we show that Lin−CD44hiSca1−cKit+CD34− cells make up ∼0.5%–1% of murine whole bone marrow cells and yield nearly an equal amount of fibroblastic colony-forming units (CFU-F) as whole bone marrow. After transplantation into lethally irradiated recipients, Lin−CD44hiSca1−cKit+CD34− cells engrafted in the bone marrow long-term and demonstrated characteristics of MSCs, including capacity to differentiate into osteoblasts and adipocytes. To examine whether Lin−CD44hiSca1−cKit+CD34− cells have immune modulatory effects, in vitro coculture with activated CD4+ T-cells resulted in decreased Th17 cell differentiation by Lin−CD44hiSca1−cKit+CD34− cells. Furthermore, serial infusions with Lin−CD44hiSca1−cKit+CD34− cells reduced the progression to low-grade gastric dysplasia in mice infected with chronic Helicobacter felis (p = .038). This correlated with reduced gastric interleukin (IL)-17F, IL-22, and ROR-γt gene expression in responding mice (p &lt; .05). These data suggest that bone marrow derived Lin−CD44hiSca1−cKit+CD34− cells have characteristics of MSCs and reduce progression of early gastric tumorigenesis induced by chronic H. felis infection. The prevention of dysplastic changes may occur through inhibition of Th17-dependent pathways.Disclosure of potential conflicts of interest is found at the end of this article.
Evaluation of the Long-Term Reconstituting Subset of Hematopoietic Stem Cells with CD150
Authors: Papathanasiou Peter , Attema Joanne L. , Karsunky Holger , Xu Jian , Smale Stephen T. , Weissman Irving L. 
Published: July 2009

AbstractBlood is a tissue with a high cell turnover rate that is constantly being replenished by bone marrow hematopoietic stem cells (HSCs) seeded during fetal ontogeny from the liver. Here we show that the long-term (LT) reconstituting subset of cKit+Thy1.1(lo)Lin(−/lo)Sca1+Flk2− HSCs is CD150+. HSCs sourced from the fetal liver show LT, multilineage engraftment from E14.5 onward, and the CD150 cell surface molecule can readily substitute Thy1.1 as a positive marker of LT-HSCs in this tissue. From both fetal liver and adult bone marrow, cKit+Thy1.1(lo)Lin(−/lo)Sca1+Flk2− CD150+ cells exhibit robust LT competitive engraftment, self-renewal, multilineage differentiation capacity, and an accessible chromatin configuration consistent with high expression of erythroid/megakaryoid genes in purified cell subsets. Our data show that, with appropriate combinations of cell surface markers, stem cells can be accurately isolated to high purity and characterized. This is important for the clarification of lineage relationships and the identification of bona fide regulators of stem cell self-renewal and differentiation both in normal and neoplastic tissues.
Haematocolpos following herbal treatment for fibroids
Authors: Maharajan Pushpakala Ajaya , Carey Matthew , Agboola Niyi 
Published: July 2009

AbstractThe authors present a case history of a woman of African origin who was found to have a gross haematocolpos and uterine fibroids following investigations for severe abdominal pain. This case highlights the importance, when treating a culturally diverse population, of recognising how practices conducted in other countries might contribute to a presenting condition. Copyright © 2009 Wiley Interface Ltd
Two‐ and Three‐Dimensional Hybrid Compounds Formed by 1,2‐, 1,3‐ and 1,4‐Cyclohexanedicarboxylates of Zinc
Authors: Ramakrishna Matte H. S. S. , Swain Sarat K. , Thirumurugan A. , Rao C. N. R. 
Published: July 2009

AbstractBy employing the hydrothermal method, five zinc cyclohexanedicarboxylates (CHDCs) with the compositions, [Zn2(1,4‐CHDC)(1,10‐phen)4]·(H2O)2(NO3)2 (I), [Zn(1,4‐CHDC)] (II), [Zn3(1,3‐CHDC)3(4,4′‐bipy)] (III), [Zn5(OH)2(1,3‐CHDC)4] (IV), and [Zn(1,2‐CHDC)] (V), were prepared and characterised. Compound I is a molecular structure while II, III and V have two‐dimensional layered structures. Compounds II, III and V are coordination polymers (I0O2) possessing zero‐dimensional inorganic connectivity (In, n = 0) and two‐dimensional organic connectivity (Om, m = 2). Compound IV is a coordination polymer (I0O3) possessing zero‐dimensional inorganic connectivity (In, n = 0) and three‐dimensional organic connectivity (Om, m = 3). In all these compounds, the CHDC anions are in the (e,e) conformation except in II, where it has the (a,e) conformation.
Umweltchemie und Ökotoxikologie in Deutschland
Authors: Lammel Gerhard , Scheringer Martin , Fischer Klaus 
Published: July 2009

Zusammenfassung

Fragestellung Wie gestaltet und ggf. verändert sich die wissenschaftliche Produktivität der Umweltchemie und Ökotoxikologie in Deutschland? So einfach die Frage klingt: Sie ist schwer zu beantworten, denn auf Fachgebieten, die per se interdisziplinär sind, sind Überlappungen zu Nachbargebieten die Regel und Abgrenzungen schwierig, zum Teil unmöglich, weil in der Literatur nicht erkennbar oder nicht erfasst. Umweltchemie und Ökotoxikologie sind oft „drin“, stehen aber nicht „drauf“ – auf den Institutsnamen, den Projekttiteln oder den Zeitschriftentiteln. Bei in hohem Maße interdisziplinären Arbeiten – Tendenz steigend – sind wir Wissenschaftler in manchen Fällen sogar selbst verlegen um eine abgrenzende Zuordnung oder empfänden eine solche als inadäquat oder artifiziell.

Ansatz Der Vorstand der Fachgruppe hat die bibliometrische Analyse anhand von Zeitschriftenstichproben als eine probate Herangehensweise für diese Frage gewählt. Nicht erfasst werden in einer solchen Stichprobe Arbeiten, die in Zeitschriften veröffentlicht wurden, die primär nicht der Umweltchemie oder Ökotoxikologie, sondern einem anderen Fach zugerechnet werden. Von der Analyse erfasst werden insbesondere aber die vielen umweltchemischen und ökotoxikologischen Arbeiten von Wissenschaftlern, deren Arbeitsschwerpunkt in einem anderen Feld liegt und die nur gelegentlich auf unseren Gebieten arbeiten, gleich welche Berufs- und Institutsbezeichnung sie tragen mögen. Diese Fehlerquelle zu vermeiden, erscheint für relative junge Fächer und stark interdisziplinäre Arbeitsgebiete prioritär.
Risk factors for obstetric fistula in the Far North Province of Cameroon
Authors: Tebeu Pierre Marie , de Bernis Luc , Doh Anderson Sama , Rochat Charles Henry , Delvaux Thérèse 
Published: July 2009

AbstractObjectiveTo describe the circumstances of occurrence and identify potential risk factors for obstetric fistula in northern Cameroon.MethodsA case series study of 42 obstetric fistula patients seeking services at the Provincial Hospital of Maroua, Cameroon, between May 2005 and August 2007. Structured interviews were conducted prior to surgical intervention.ResultsAmong obstetric fistula patients, 60% had lived with obstetric fistula for more than 5 years at the time of surgery. Eighty‐one percent of patients had received no formal education and 86% were teenagers at their first delivery. Regarding the pregnancy and delivery preceding the occurrence of the fistula, 50% of women reported that they had received no prenatal care and 76% were in labor for more than 12 hours. The majority (83%) of women delivered a stillborn baby.ConclusionsObstetric fistula patients in the Far North Province of Cameroon had a low level of education, were married at a young age, and had poor access to quality maternal healthcare services.