bluuebunny/crossref_metadata_2025_split huggingface dataset:
In Patients Younger Than Age 55 Years With Lymph Node–Negative Breast Cancer, Proliferation by Mitotic Activity Index Is Prognostically Superior to Adjuvant!
Authors: Lende Tone Hoel , Janssen Emiel A.M. , Gudlaugsson Einar , Voorhorst Feja , Smaaland Rune , van Diest Paul , Søiland Håvard , Baak Jan P.A. 
Published: December 2010

Purpose In breast cancer, different tools are used for prognostication and adjuvant systemic therapy selection. We compared the accuracy of the online program Adjuvant!, the Norwegian Breast Cancer Group (NBCG) guidelines, and the proliferation factor mitotic activity index (MAI) in patients with lymph node (LN) –negative disease (pN0). Patients and Methods Adjuvant! and MAI thresholds were set to 90% to 95% breast cancer–specific survival (BCSS) rates. These thresholds were 95% for Adjuvant!, 3 for MAI, and as follows for NBCG: pT1 grade 1 + pT1a-b grade 2 to 3; all pN0M0 and estrogen receptor/progesterone receptor positive versus all others. In 516 patients younger than age 55 years (T1-3N0M0) without adjuvant systemic therapy, univariable and multivariable 10-year BCSS rates were estimated. Results Median follow-up time was 118 months. The concordance between MAI and Adjuvant! or NBCG was fair (κ = 0.35 and κ = 0.29, respectively). Adjuvant!, NBCG, and MAI were all prognostically significant (P ≤ .001). In the univariable analysis, the 10-year BCSS of MAI less than 3 versus ≥ 3 was 95% v 71%, respectively, with a hazard ratio of 7.0. In multivariable analysis, MAI was superior to Adjuvant! and NBCG. The 10-year survival of Adjuvant! ≥ 95% versus less than 95% was 91% v 74%, respectively, but stratification by MAI identified subgroups with different prognosis. Similar results occurred for NBCG and MAI. Adjuvant! and NBCG were not prognostic to each other. Conclusion MAI is superior to Adjuvant! and NBCG in prognostication of patients with LN-negative breast cancer younger than age 55 years.
How Long Have I Got? Estimating Typical, Best-Case, and Worst-Case Scenarios for Patients Starting First-Line Chemotherapy for Metastatic Breast Cancer: A Systematic Review of Recent Randomized Trials
Authors: Kiely Belinda E. , Soon Yu Yang , Tattersall Martin H.N. , Stockler Martin R. 
Published: December 2010

Purpose To estimate scenarios for survival for women with metastatic breast cancer (MBC) who are starting chemotherapy. Patients and Methods We sought randomized, first-line chemotherapy trials for MBC published from 1999 to 2009. We recorded median progression-free survival (PFS) and median overall survival (OS) and extracted the following percentiles (represented scenario) from each OS curve: 90th (worst-case), 75th (lower-typical), 25th (upper-typical), and 10th (best-case). We also estimated these scenarios for each OS curve by multiplying its median by four simple multiples: 0.25 (worst-case), 0.5 (lower-typical), 2 (upper-typical), and 3 (best-case). Estimates were deemed accurate if they were within 0.75 to 1.33 times the actual value. Results From 36 trials (13,083 women), the mean for median PFS was 7.6 months (interquartile range [IQR], 6.0 to 9.0 months), the mean for median OS was 21.7 months (IQR,18.2 to 24.0 months), and the mean for the ratio of median OS to median PFS was 3.0 (IQR, 2.4 to 3.5). The mean for each OS scenario was worst-case, 6.3 months (IQR, 4.8 to 7.5 months); lower-typical, 11.9 months (IQR, 9.9 to 13.2 months); upper-typical, 36.2 months (IQR, 31.1 to 41.3 months); and best-case, 55.8 months (IQR, 47.5 to 60.2 months). Simple multiples of the median gave accurate estimates of the worst-case scenario in 73% of OS curves, lower-typical in 97%, upper-typical in 95%, and best-case in 96%. OS was longer in trials with higher proportions of estrogen receptor–positive tumors (P = .001) and in trials of trastuzumab-treated human epidermal growth factor receptor 2–positive tumors (P = .001). Conclusion Simple multiples of an OS curve's median can accurately estimate typical (half to double the median), best-case (triple the median), and worst-case (one quarter of the median) scenarios for survival.
Bortezomib Plus CHOP-Rituximab for Previously Untreated Diffuse Large B-Cell Lymphoma and Mantle Cell Lymphoma
Authors: Ruan Jia , Martin Peter , Furman Richard R. , Lee Shing M. , Cheung Ken , Vose Julie M. , LaCasce Ann , Morrison Julia , Elstrom Rebecca , Ely Scott , Chadburn Amy , Cesarman Ethel , Coleman Morton , Leonard John P. 
Published: December 2010

PurposeThe proteasome inhibitor bortezomib may enhance activity of chemoimmunotherapy in lymphoma. We evaluated dose-escalated bortezomib plus standard cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP) plus rituximab (R) in patients with diffuse large B-cell lymphoma (DLBCL) and mantle cell lymphoma (MCL).Patients and MethodsSeventy-six subjects with untreated DLBCL (n = 40) and MCL (n = 36) received standard CHOP every 21 days (CHOP-21) with R plus bortezomib at 0.7 mg/m2(n = 4), 1.0 mg/m2(n = 9), or 1.3 mg/m2(n = 63) on days 1 and 4 for six cycles.ResultsMedian age was 63 years (range, 20 to 87), and International Prognostic Index (IPI) scores were generally unfavorable (39% with IPI of 2, and 49% with IPI of 3 to 5), as were Mantle Cell Lymphoma International Prognostic Index scores in patients with MCL (28% intermediate risk and 39% high risk). Toxicity was manageable, including neuropathy in 49 subjects (8% grade 2 and 4% grade 3) and grade 3/4 anemia (13%), neutropenia (41%), and thrombocytopenia (25%). For DLBCL, the evaluable overall response rate (ORR) was 100% with 86% complete response (CR)/CR unconfirmed (CRu; n = 35). Intent-to-treat (ITT, n = 40) ORR was 88% with 75% CR/CRu, 2-year progression-free survival (PFS) of 64% (95% CI, 47% to 77%) and 2-year overall survival (OS) of 70% (95% CI, 53% to 82%). For MCL, the evaluable ORR was 91% with 72% CR/CRu (n = 32). The ITT (n = 36) ORR was 81% with 64% CR/CRu, 2-year PFS 44% (95% CI, 27% to 60%) and 2-year OS 86% (95% CI, 70% to 94%). IPI and MIPI correlated with survival in DLBCL and MCL, respectively. Unlike in DLBCL treated with R-CHOP alone, nongerminal center B cell (non-GCB) and GCB subtypes had similar outcomes.ConclusionBortezomib with R-CHOP-21 can be safely administered and may enhance outcomes, particularly in non-GCB DLBCL, justifying randomized studies.
Familial Risks in Cancer of Unknown Primary: Tracking the Primary Sites
Authors: Hemminki Kari , Ji Jianguang , Sundquist Jan , Shu Xiaochen 
Published: December 2010

Purpose Cancer of unknown primary (CUP) is diagnosed at the metastatic stage, and despite extensive diagnostic work-up, the primary tumor often remains unidentified. No data are available on familial clustering of CUP. We hypothesize that familial clustering of CUP with other cancers may be informative of the primary sites. Patients and Methods A total of 35,168 patients with CUP were identified in the Swedish Family-Cancer Database, and risks between family members were calculated for concordant (CUP-CUP) and discordant (CUP-any other cancer) cancers using standardized incidence ratio (SIR). Results Familial cases of CUP accounted for 2.8% of all CUP cases in the offspring generation. Familial SIR for CUP was 1.69 when a sibling was diagnosed with CUP. As to discordant associations between siblings, CUP was associated with lung (SIR, 1.87), kidney (SIR, 1.82), liver (SIR, 1.67), ovarian (SIR, 1.45), colorectal (SIR, 1.26), and breast (SIR, 1.15) cancers and melanoma (SIR, 1.26). Upper aerodigestive tract, bladder, pancreatic, and prostate cancers were additionally associated with CUP. Notably, CUP was associated with families of kidney, lung, and colorectal cancers. Conclusion The present data show that CUP is not a disease of random metastatic cancers but, instead, a disease of a defined set of cancers. The association of CUP with families of kidney, lung, and colorectal cancers suggests a marked genetic basis and shared metastatic mechanisms by many cancer types. Familial sites shared by CUP generally match those arising in tissue-of-origin determinations and, hence, suggest sites of origin for CUP. Mechanistic exploration of CUP may provide insight into defense against primary tumors and the metastatic process.
Synthesis of a Doubly Strapped Light-Harvesting Porphyrin Bearing Energy Donor Molecules Hanging on to the Straps: An Attempt toward Macroscopic Control over Molecular Conformation that Affects the Efficiency of Fluorescence Resonance Energy Transfer
Authors: Ogi Soichiro , Sugiyasu Kazunori , Takeuchi Masayuki 
Published: December 2010

Abstract
We report here the synthesis of a light-harvesting molecule 1, in which 5,5′-diphenyl-2,2′-bithiophene units (energy donors) and a doubly strapped porphyrin (energy acceptor) are three-dimensionally connected through four alkyl chains to form a “universal joint”-like architecture. From the results of the optical properties of 1 in solution, fluorescence resonance energy transfer (FRET) takes place from the donor to the acceptor in 1 with the FRET efficiency of 99.7%. We prepared 1/polydimethylsiloxane (PDMS) elastomeric films in which 1 is connected to a polysiloxane network through covalent bonds. When we stretched the 1/PDMS film (elongation: up to 60%), the FRET efficiency decreased by 13.1%. The theoretical analysis suggests that the FRET efficiency of 1 (E) is virtually uninfluenced by any changes in the distance between the donor and acceptor (r). Therefore, the observed change in FRET efficiency should have been derived from the orientation factor (κ2), which describes the relative orientation of the emission transition dipole of the donor and the absorption transition dipole of the acceptor. The anisotropic absorption spectral measurements support the notion that the transition dipoles of the fluorophores became orthogonally aligned upon stretching, as expected from the molecular design.
Rumphellclovane B, a Novel Clovane Analogue from the Gorgonian Coral Rumphella antipathies
Authors: Chung Hsu-Ming , Hwang Tsong-Long , Chen Yung-Husan , Su Jui-Hsin , Lu Mei-Chin , Chen Jih-Jung , Li Jan-Jung , Fang Lee-Shing , Wang Wei-Hsien , Sung Ping-Jyun 
Published: December 2010

Abstract
A novel clovane-type sesquiterpenoid derivative, rumphellclovane B (1), which possesses an unprecedented δ-lactone moiety, and a new natural clovane, 9α-hydroxyclovan-2-one (2), were isolated from the gorgonian coral Rumphella antipathies. The structures of clovanes 1 and 2 were elucidated by interpretations of spectral data. A plausible biosynthetic pathway between these two compounds was proposed. Compound 1 displayed inhibitory effects on superoxide anion generation by human neutrophils.
Electroactive Nanotubes from π-Conjugated Discotic Molecules
Authors: Yamamoto Yohei 
Published: December 2010

Abstract
Self-assembly of π-conjugated molecules is attractive for construction of well-defined, nanometer-scale electroactive materials. This account describes our developments on self-assembled nanotubes from Gemini-shaped hexa-peri-hexabenzocoronenes (HBCs). At first, detailed molecular arrangement in the nanotube is presented, which is perfectly revealed by a synchrotron radiation X-ray diffraction analysis of a macroscopic fiber consisting of highly aligned HBC nanotubes. Next, electroconductive properties of the HBC nanotubes are investigated. By means of direct current and noncontact methods, anisotropic charge-transport properties in the nanotubes are confirmed. The effect of the surface oligoether chains on intertubular conduction is also examined by field-effect transistor measurements. Finally, optoelectronic applications are developed by constructing newly designed nanotubes. These nanotubes possess a coaxial configuration, where an electron-donating graphitic bilayer of π-stacked HBC arrays is laminated by an electron-accepting molecular layer. Due to the molecular-layer donor/acceptor heterojunction, the nanotubes exhibit remarkable photoconduction and photovoltaic outputs. Furthermore, the optoelectronic properties are modulated by changing the density of electron acceptors on the nanotube surfaces by coassembly of multiple components or utilizing photochromism. These results will advance to electronic and optoelectronic applications of supramolecular nanomaterials.
Ondansetron-Induced Dystonia, Hypoglycemia, and Seizures in a Child
Authors: Patel Aneet , Mittal Shweta , Manchanda Samiksha , Puliyel Jacob Mammen 
Published: December 2010

Objective To document ondansetron-induced dystonia, hypoglycemia, and seizures in a child. Case Summary: A 4-year-old boy was admitted with dystonia following an intravenous dose of ondansetron 2 mg (0,13 mg/kg) that he had received for vomiting that day. In the emergency department, he developed generalized tonic-clonic seizures lasting for a few minutes. He was administered lorazepam 1.5 mg (0.1 mg/kg) to control the seizures. His blood glucose level was 10 mg/dL; the hypoglycemia responded promptly to intravenous dextrose 10% (7 mL/kg). Serum electrolytes, renal profile, capillary blood gas, and results of a computed tomography scan of the brain were normal. Subsequent blood glucose values were within normal range. On follow-up after 7 days, the child was healthy with no recurrences of the symptoms. A provisional diagnosis of ondansetron-induced acute dystonia with seizures and hypoglycemia was made. Discussion: Ondansetron is an antiemetic known for its safety profile. There have been a few case reports of extrapyramidal adverse effects and seizures from this drug but none of ondansetron-associated hypoglycemia, 5-Hydroxytryptamine (5-HT3) receptors are involved in arginine vasopressin–mediated release of adrenocorticotrapin hormone and Cortisol in response to stress. Blunting of this stress response by ondansetron, a 5-HT3 receptor antagonist, could have caused the hypoglycemia in this patient. According to the Naranjo scale, ondansetron was probably the cause of the dystonia and seizures, and possibly the cause of the hypoglycemia. Other potential explanations for hypoglycemia were considered but were thought to be less likely. Conclusions: Dystonia and seizures have been associated with ondansetron in a few case reports. In addition, clinicians need to consider hypoglycemia as a possible adverse effect of ondansetron.
Nonfasting Lipids, Lipoproteins, and Apolipoproteins in Individuals with and without Diabetes: 58 434 Individuals from the Copenhagen General Population Study
Authors: Langsted Anne , Nordestgaard Børge G 
Published: December 2010

BACKGROUNDWhether lipid profiles should be collected from fasting or nonfasting individuals is controversial, particularly in the diabetic population. We examined the influence of normal food intake on lipid profiles in diabetic and nondiabetic individuals.METHODSWe assessed plasma concentrations of lipids, lipoproteins, apolipoproteins, and albumin as a function of time since the last meal in 58 434 individuals (participation rate 45%) from the general population, 2270 of whom had diabetes mellitus.RESULTSSimilar patterns in the measured constituents were observed in the diabetic and nondiabetic populations. Triglycerides remained increased for 6–7 h in both populations after the last meal, whereas LDL cholesterol and albumin but not apolipoprotein B were reduced in both populations up to 5 h after normal food intake; after adjustment for hemodilution on the basis of albumin concentrations, the LDL cholesterol reductions were no longer present. Maximum observed mean differences from fasting concentrations in diabetic patients were −0.6 mmol/L, 0 mmol/L, 0.2 mmol/L, and 0.08 g/L (8 mg/dL) for LDL cholesterol, HDL cholesterol, triglycerides, and apolipoprotein B, respectively, and, correspondingly, −0.3 mmol/L, 0 mmol/L, 0.2 mmol/L, and 0.03 g/L (3 mg/dL) in individuals without diabetes.CONCLUSIONSTriglycerides increased up to 0.2 mmol/L after normal food intake in individuals with and without diabetes, whereas the postprandial reductions in LDL cholesterol observed in both populations likely were caused by hemodilution due to fluid intake. No statistically significant differences in postprandial apolipoprotein B concentrations were found. These data may be useful for discussion during revisions of guidelines for lipid measurements in individuals with or without diabetes.
Cyberbullying: Labels, Behaviours and Definition in Three European Countries
Authors: Nocentini Annalaura , Calmaestra Juan , Schultze-Krumbholz Anja , Scheithauer Herbert , Ortega Rosario , Menesini Ersilia 
Published: December 2010

AbstractThis study aims to examine students' perception of the term used to label cyberbullying, the perception of different forms and behaviours (written, verbal, visual, exclusion and impersonation) and the perception of the criteria used for its definition (imbalance of power, intention, repetition, anonymity and publicity) in three different European countries: Italy, Spain and Germany. Seventy adolescents took part in nine focus groups, using the same interview guide across countries. Thematic analysis focused on three main themes related to: (1) the term used to label cyberbullying, (2) the different behaviours representing cyberbullying, (3) the three traditional criteria of intentionality, imbalance of power and repetition and the two new criteria of anonymity and publicity. Results showed that the best word to label cyberbullying is ‘cyber-mobbing’ (in Germany), ‘virtual’ or ‘cyber-bullying’ (in Italy), and ‘harassment’ or ‘harassment via Internet or mobile phone’ (in Spain). Impersonation cannot be considered wholly as cyberbullying behaviour. In order to define a cyberbullying act, adolescents need to know whether the action was done intentionally to harm the victim, the effect on the victim and the repetition of the action (this latter criterion evaluated simultaneously with the publicity). Information about the anonymity and publicity contributes to better understand the nature and the severity of the act, the potential effects on the victim and the intentionality.
Cyber-Aggression: Definition and Concept of Cyberbullying
Authors: Grigg Dorothy Wunmi 
Published: December 2010

AbstractThis study examined definitions and concepts of cyberbullying. It identified words, terms and definitions used for negative acts on the internet and mobile phones across different age groups in the United Kingdom. Young people and adults' (N = 32; age = 8–54) constructs and perceptions of negative online behaviours were also reported. Focus groups and individual interviews were employed using qualitative triangulation: Thematic Analysis and Interpretative Phenomenological Analysis. The study examined current definitions and concepts of cyberbullying and how these differ in its findings; and considered different ways to foster positive online behaviour for the context of practitioners. The concept of cyber-aggression is used to describe a wide range of behaviours other than cyberbullying. The findings indicate that there is a need to include a broader definition in line with the current trend of a range of behaviours that are common with internet and mobile phone usage.
Addressing Cyberbullying in School Using the Quality Circle Approach
Authors: Paul Simone , Smith Peter K. , Blumberg Herbert H. 
Published: December 2010

AbstractCyberbullying has become a significant area of concern, yet research is still at an early stage. The Quality Circle approach allows explorative analysis of cyberbullying in school settings by identifying issues for further consideration. In this study of cyberbullying in one UK secondary school, Quality Circle participants were required to establish a small anti-bullying taskforce, and then with the guidance of a facilitator, embark on a problem-solving exercise over a period of time. The process involves identifying key issues and prioritising concerns, analysing problems and generating solutions, through participation in a series of themed workshops. Six Quality Circle groups were formed, and the work produced during practical activities was documented and discussions recorded as evidence of emerging themes. The areas of interest regarding cyberbullying were the differing perceptions reported by each representative group, and collectively the range of problems and solutions identified.
Analysis of Experts' and Trainers' Views on Cyberbullying
Authors: Jäger Thomas , Amado João , Matos Armanda , Pessoa Teresa 
Published: December 2010

AbstractPartners from nine European countries developed a cyberbullying training manual for the benefit of trainers working with parents, school staff and young people.1The development of the training manual built on a two-level qualitative research process that combined elements of the Delphi method and online focus groups. The two studies outlined in this article aimed to assess trainers' and experts' views on the problem of cyberbullying while also gathering insight in relation to their preferences in terms of a training manual. This article outlines the main outcomes of a content analysis of experts' and trainers' views. According to experts and trainers, the sources of cyberbullying were specifically related to new technical developments and new patterns of usage, a lack of media literacy and media education, and the lack of appropriate laws, control and reporting mechanisms. Approaches for tackling cyberbullying suggested by experts and trainers included the provision of enhanced information on ICT and e-safety, adequate rules, monitoring mechanisms and sanctions. Furthermore a range of approaches targeting children and young people, parents and other adults, schools as well as approaches run by authorities and IT providers were suggested. In terms of the elements and style of a training manual, experts and trainers emphasised that it should be practically oriented, and that elements like narratives, case examples or video clips would be vital for the implementation of training.
Cyberbullying at School: Good Practice and Legal Aspects in the United Kingdom
Authors: Marczak Magdalena , Coyne Iain 
Published: December 2010

AbstractCyberbullying at school has emerged as a new, electronic form of bullying and harassment and is recognised as a growing problem all over the world. The ability to use cyberspace to bully others means that harassment, rumours and intimidation can reach a much wider audience. Although research has not as yet explored fully the consequences of either cyber-victimisation or cyberbullying, it would appear that they may be detrimental to the health of young people, suggesting the need for policies and interventions, which some European countries (e.g., Germany, Luxemburg, Belgium and the United Kingdom) have attempted to undertake. Currently, however, only the United States has implemented specific laws that treat cyberbullying as a criminal offence per se. After briefly considering the literature on cyberbullying this article will focus on the legal, regulatory and good practice frameworks for controlling cyberbullying in UK educational contexts.