bluuebunny/crossref_metadata_2025_split huggingface dataset:
Workforce Diversity and Organisational Development: A Study of Federal Inland Revenue, Abakaliki, Ebonyi State, Nigeria
Authors: Anigbata Davidson O. , Ezebuilo Paul Chibuike , Chukwudi Celestina Ekene , Ogbonna Symplus 
Published: May 2024

Organizations all over the world are facing many challenges in the management of their workforce. One of the challenges is workforce diversity. Thus, because they are recruiting people from different backgrounds. The paper sought to examine the effects of workforce diversity in the federal inland revenue service Abakaliki. The broad objective of the paper is to examine the effect of workforce diversity in organizational management. The specific objectives are to find out whether workforce diversity brings about industrial harmony or disharmony; to ascertain the effects of managing multicultural organization and to examine the impacts of workforce diversity in the organizational development of federal Inland Revenue Service Abakalliki. Content Analysis was used in the study. This is because the study relies mainly on secondary data. Situational theory propounded by Fieldler, A (1967) was used as the basis upon which the framework of the study is hinged. The paper after analyses found that workforce diversity is an inevitable organizational challenge if organizations are recruiting workforce from diverse environments etc. The study therefore recommended that management should brace up for the challenges of managing multi-cultural organizations among others. The study implies that as many people from different strata of society are employed in organizations, workforce diversity, and conflicts are inevitable. The only panacea for the problems is to develop an organizational culture to is attuned to relativism; the failure of which industrial disputes, chaos, and mutual suspicion are evident.

Received: 23 March 2024 / Accepted: 30 April 2024 / Published: 5 May 2024
Nano Revolution: Smart Therapeutics Unleash with Nanomaterials
Authors: Bikash Medhi  , Charan Shiv , Soloman Singh Rahul , Gladson David Masih  , Benjamin Suroy  
Published: May 2024

Nanotechnology explores substances and technologies organized at the nanoscale level, measuring one billionth of a meter in at least one dimension. This field of study encompasses both science and engineering1. At these scales, the individual molecules and interacting groups of molecules play a crucial role in determining the bulk macroscopic properties of materials or devices. The ability to manage the fundamental molecular structure grants control over the macroscopic chemical and physical properties2. In the realms of physiology and medicine, there are intriguing applications involving substances and tools designed to precisely interact with the body at subcellular or molecular dimensions. These advancements hold promise for targeted interventions and therapies, ushering in a new era of precision medicine. This may result in tailored, tissue- and cell-specific clinical applications that aim to maximize therapeutic benefits while minimizing adverse consequences. The scientific and technological dimensions of nanotechnology, are accompanied by an exploration of potential therapeutic applications. It is essential to recognize that nanotechnology does not exist in isolation; rather, it emerges from the synergistic convergence of established disciplines such as biology, chemistry, physics, and materials science. This interdisciplinary approach provides the foundational knowledge necessary for advancing these cutting-edge technologies.
Design and Development of Fast-dissolving Tablets of Apixaban using Single Coprocessed Excipient
Authors: Jaiswal Sourabh , Kanugo Abhishek 
Published: May 2024

Background: Apixaban is administered orally as an anticoagulant action and minimizes the chances of strokes and systemic embolism. The conventional film-coated tablet showed less bioavailability due to its minimal solubility in the gastrointestinal tract.
Rationale: The goal of designing the current analysis is to prepare a prompt release tablet using a single Coprocessed excipient which minimizes multistep processing, time, and cost effectiveness.
Methods: The prompt release tablets of Apixaban were developed by direct compression technique using multifunctional material like Prosolve ODT G2 and Prosolve Easytab. Drug excipients inertness was confirmed with FTIR and DSC. Flowing characteristics of Apixaban and co-processed excipients were evaluated in terms of Carr’s index, Angle of repose, and Hausner’s ratio. These co-processed excipients indicated exceptional flowing and compression characteristics. The ready tablets were assessed for weight variation, hardness, friability, dispersion time, disintegration, and dissolution studies.
Results: Among 12 batches, the least disintegration time was shown with C6 with a cumulative drug release of 99.06 % within 25 min. The optimized batch C6 was highly stable when tested under stability guidelines at 40 0 C and at 75 % relative humidity.
Conclusion: Among these co-processed excipients, Prosolve Easytab SP was found the best one for direct compression intended for the immediate or fast dissolving tablets.
Utilización de Psicofármacos en la Población: Una Revisión de Literatura
Authors: Sánchez Prado Raquel Estefanía , Dután Torres Fausto Baldemar , Geovanny Efrén Ramon Japón , Maldonado Encalada Yomara Solange , Barros Navarrete Katherine Estefanía 
Published: May 2024

La relevancia de la salud mental en la sociedad contemporánea la posiciona como una esfera crucial en los centros de atención sanitaria, debido a la alta incidencia de trastornos mentales, el sufrimiento que experimentan los pacientes y el uso de medicamentos psicofármacos. Los psicofármacos son un tipo de medicamentos que se usan en el tratamiento de enfermedades de salud mental y trastorno mental grave, se clasifican en cuatro grandes grupos: antidepresivos, ansiolíticos, estabilizadores del estado de ánimo, antipsicóticos. Por este motivo, el objetivo de la presente investigación fue realizar una revisión bibliográfica sobre la utilización de psicofármacos en la población, centrándose en estudios publicados en los últimos 5 años. La metodología empleada fue de tipo no experimental, bibliográfica y descriptiva, consistiendo en la recopilación y análisis de artículos científicos publicados en los últimos 5 años en diversas bases de datos como PubMed, Scielo, Dialnet y Google Scholar. Como resultados obtenidos: Los artículos detectados relacionados a uso de psicofármacos se distribuyen de la siguiente manera: el 40% se encuentran en la base de datos de PubMed, el 36% en Dialnet, el 12 % en Scielo y Google Scholar. Por otra parte, en el 40% de los artículos encontrados mencionan que el sexo más consumidor de psicofármacos es femenino. En el 84% de los artículos encontrados la población consumió antidepresivos, en el 44% ansiolíticos, en el 36% antipsicóticos y el 12% estabilizadores el ánimo, estos hallazgos subrayan la importancia de continuar investigando y abordando el uso de psicofármacos, así como la necesidad de comprender mejor cómo estos afectan a diferentes poblaciones.
The The Application of E-Government in the Development of Village Government Democracy in Gowa Regency Indonesia
Authors: Anas Andika , Arifin Indar , Irwan A Lukman , Ansar Muhammad Chaeroel 
Published: May 2024

The use of e-government in Gowa Regency's villages to improve democracy is the subject of this study. The primary issue facing village governance in the digital age is how information technology may be used to increase citizen participation, transparency, and accountability. This study is unique in that it examines how e-government interacts with the still-unexplored village governance context. The main inquiries this study aims to address are: What ways may the Gowa Regency's village governments be made more democratic through the use of e-government ? In three villages in Gowa Regency, case studies were used in the research method, which was qualitative. Observation, interviews, documentation, and literature review were used to gather data. According to the findings, using e-government improved community engagement, boosted budget management transparency, and promoted village government accountability. The major finding is that e-government has a lot of promise to improve village governance through democracy. The necessity for digital literacy and a strong technological foundation, as well as the importance of village governments in promoting public engagement and ensuring openness and accountability in the use of information technology, are all important implications. This study adds significantly to the local and international literature on e-government and local democracy by providing a new understanding of how e-government is used to strengthen democracy in the context of village governance.
Двовимірні неізотропні поверхні з плоскою нормальною зв’язністю і невиродженим грассмановим образом сталої кривини у просторі Мінковського
Authors: Stegantseva P. , Grechneva M. 
Published: May 2024

УДК 514.764
Знайдено значення, яких може набувати кривина грассманового многовиду вздовж площин, дотичних до грассманового образу двовимірної неізотропної поверхні з плоскою нормальною зв’язністю у чотиривимірному просторі Мінковського. Показано, що у випадку часоподібної поверхні з плоскою нормальною зв’язністю кривина набуває значень з множини

[
0,1
]

.

Якщо ж поверхня з плоскою нормальною зв’язністю є просторовоподібною, то значення цієї кривини належать множині

(
-
∞
,
-
1
]

у випадку просторовоподібного грассманового образу і є невід'ємними у випадку часоподібного грассманового образу. Доведено існування двовимірних неізотропних поверхонь з плос\-кою нормальною зв’язністю та сталою кривиною їх грассманового образу для всіх значень кривини зі знайдених множин.
“Extended Emission” from Fallback Accretion onto Merger Remnants
Authors: Musolino Carlo , Duqué Raphaël , Rezzolla Luciano 
Published: May 2024

Abstract
Using a set of general-relativistic magnetohydrodynamics simulations that include proper neutrino transfer, we assess for the first time the role played by the fallback accretion onto the remnant from a binary neutron star merger over a timescale of hundreds of seconds. In particular, we find that, independently of the equation of state, the properties of the binary, and the fate of the remnant, the fallback material reaches a total mass of ≳10−3
M
⊙, i.e., about 50% of the unbound matter, and that the fallback accretion rate follows a power law in time with slope ∼t
−5/3. Interestingly, the timescale of the fallback and the corresponding accretion luminosity are in good agreement with the so-called “extended emission” observed in short gamma-ray bursts (GRBs). Using a simple electromagnetic emission model based on the self-consistent thermodynamical state of the fallback material heated by r-process nucleosynthesis, we show that this fallback material can shine in gamma and X-rays with luminosities ≳1048 erg s−1 for hundreds of seconds, thus making it a good and natural candidate to explain the extended emission in short GRBs. Additionally, our model for fallback emission reproduces well and rather naturally some of the phenomenological traits of extended emission, such as its softer spectra with respect to the prompt emission and the presence of exponential cutoffs in time. Our results clearly highlight that fallback flows onto merger remnants cannot be neglected, and the corresponding emission represents a very promising and largely unexplored avenue to explain the complex phenomenology of GRBs.
Une crise du travail française
Authors: Méda Dominique 
Published: May 2024

Alors que l’espace public est rempli de rumeurs stigmatisant la préférence française pour le loisir, pointant du doigt une « épidémie de flemme » et la perte du sens de l’effort, cet article s’intéresse à la dégradation des conditions de travail, particulièrement intense en France, qui continue malheureusement de faire l’objet d’un véritable déni.
Structuration des pratiques de gestion des ressources humaines dans les entreprises familiales : entre découragement et persévérance
Authors: Goter Françoise 
Published: May 2024

Dans cet article, nous étudions l’évolution des pratiques RH d’une entreprise familiale de 120 personnes, dont les données (entretiens, indicateurs RH…) ont été collectées dans le cadre d’une recherche-intervention longitudinale de sept ans. Jusqu’à présent la littérature indique que les entreprises familiales favorisent les pratiques de GRH informelles, facteurs de confiance et de travail en équipe entre les membres de la famille et les non membres. De plus, peu de travaux font le rapprochement entre l’état des pratiques RH des entreprises familiales et leurs résultats socio-économiques. Or, notre étude montre que les pratiques informelles de GRH peuvent être une « zone de confort », génératrices de dysfonctionnements, de démotivation, d’absentéisme, de rotation du personnel et de perte de productivité au sein des entreprises familiales. À contrario, la professionnalisation des pratiques RH est source de cohésion entre les membres de la famille, de transparence auprès des équipes et d’amélioration des conditions de travail.
Contrats de travail et emploi dans un modèle ville-périphérie
Authors: Contensou François , Vranceanu Radu 
Published: May 2024

Prenant en considération l’accroissement des coûts de transport subis par les travailleurs, cet article propose d’étudier la formation des contrats de travail conçus par un employeur s’adressant à deux populations de collaborateurs, populations qui diffèrent par la distance séparant leur domicile et le lieu de production. L’employeur cherche à en obtenir un volume d’heures prédéterminé. L’état de la législation du travail explique que des contrats distincts sont possibles mais soumis au libre choix des travailleurs, la discrimination explicite étant exclue. Le modèle précise l’effet des différences de coût et de durée du transport sur les rémunérations et les horaires choisis par l’employeur, et sur les effectifs demandés des deux catégories. Classification JEL : D82, D86, J31, R29.
Prognostic relevance of ventricular arrhythmias in surgical patients with gastrointestinal tumors
Authors: Xue Jiao-Jie , Hu Su-Tian , Wang Chong-Chong , Chen Zhi-Chong , Cheng Shi-Yao , Yu Shu-Qi , Peng Hua-Jing , Zhang Yi-Tao , Zeng Wei-Jie 
Published: May 2024

BACKGROUND
Individuals diagnosed with gastrointestinal tumors are at an increased risk of developing cardiovascular diseases. Among which, ventricular arrhythmia is a prevalent clinical concern. This suggests that ventricular arrhythmias may have predictive value in the prognosis of patients with gastrointestinal tumors.
AIM
To explore the prognostic value of ventricular arrhythmias in patients with gastrointestinal tumors receiving surgery.
METHODS
We retrospectively analyzed data from 130 patients undergoing gastrointestinal tumor resection. These patients were evaluated by a 24-h ambulatory electrocardiogram (ECG) at the Sixth Affiliated Hospital of Sun Yat-sen University from January 2018 to June 2020. Additionally, 41 general healthy age-matched and sex-matched controls were included. Patients were categorized into survival and non-survival groups. The primary endpoint was all-cause mortality, and secondary endpoints included major adverse cardiovascular events (MACEs).
RESULTS
Colorectal tumors comprised 90% of cases. Preoperative ambulatory ECG monitoring revealed that among the 130 patients with gastrointestinal tumors, 100 (76.92%) exhibited varying degrees of premature ventricular contractions (PVCs). Ten patients (7.69%) manifested non-sustained ventricular tachycardia (NSVT). The patients with gastrointestinal tumors exhibited higher PVCs compared to the healthy controls on both conventional ECG [27 (21.3) vs 1 (2.5), P = 0.012] and 24-h ambulatory ECG [14 (1.0, 405) vs 1 (0, 6.5), P < 0.001]. Non-survivors had a higher PVC count than survivors [150.50 (7.25, 1690.50) vs 9 (0, 229.25), P = 0.020]. During the follow-up period, 24 patients died and 11 patients experienced MACEs. Univariate analysis linked PVC > 35/24 h to all-cause mortality, and NSVT was associated with MACE. However, neither PVC burden nor NSVT independently predicted outcomes according to multivariate analysis.
CONCLUSION
Patients with gastrointestinal tumors exhibited elevated PVCs. PVCs > 35/24 h and NSVT detected by 24-h ambulatory ECG were prognostically significant but were not found to be independent predictors.
Correlation of tumor-associated macrophage density and proportion of M2 subtypes with the pathological stage of colorectal cancer
Authors: Fazal Fouzia , Khan Muhammad Arsalan , Shawana Sumayya , Rashid Rahma , Mubarak Muhammed 
Published: May 2024

BACKGROUND
Colorectal cancer (CRC) is a prevalent global malignancy with complex prognostic factors. Tumor-associated macrophages (TAMs) have shown paradoxical associations with CRC survival, particularly concerning the M2 subset.
AIM
We aimed to establish a simplified protocol for quantifying M2-like TAMs and explore their correlation with clinicopathological factors.
METHODS
A cross-sectional study included histopathological assessment of paraffin-embedded tissue blocks obtained from 43 CRC patients. Using CD68 and CD163 immunohistochemistry, we quantified TAMs in tumor stroma and front, focusing on M2 proportion. Demographic, histopathological, and clinical parameters were collected.
RESULTS
TAM density was significantly higher at the tumor front, with the M2 proportion three times greater in both zones. The tumor front had a higher M2 proportion, which correlated significantly with advanced tumor stage (P = 0.04), pathological nodal involvement (P = 0.04), and lymphovascular invasion (LVI, P = 0.01). However, no significant association was found between the M2 proportion in the tumor stroma and clinicopathological factors.
CONCLUSION
Our study introduces a simplified protocol for quantifying M2-like TAMs in CRC tissue samples. We demonstrated a significant correlation between an increased M2 proportion at the tumor front and advanced tumor stage, nodal involvement, and LVI. This suggests that M2-like TAMs might serve as potential indicators of disease progression in CRC, warranting further investigation and potential clinical application.
SERPINH1 promoted the proliferation and metastasis of colorectal cancer by activating PI3K/Akt/mTOR signaling pathway
Authors: Jin Xiao-Sheng , Chen Lu-Xi , Ji Ting-Ting , Li Rong-Zhou 
Published: May 2024

BACKGROUND
Serpin peptidase inhibitor clade H member 1 (SERPINH1) was initially recognized as an oncogene implicated in various human malignancies. Nevertheless, the clinical relevance and functional implications of SERPINH1 in colorectal cancer (CRC) remain largely elusive.
AIM
To investigate the effects of SERPINH1 on CRC cells and its specific mechanism.
METHODS
Quantitative real-time polymerase chain reaction, western blotting analysis, The Cancer Genome Atlas data mining and immunohistochemistry were employed to examine SERPINH1 expression in CRC cell lines and tissues. A series of in-vitro assays were performed to demonstrate the function of SERPINH1 and its possible mechanisms in CRC.
RESULTS
SERPINH1 demonstrated elevated expression levels in both CRC cells and tissues, manifested at both mRNA and protein tiers. Elevated SERPINH1 levels correlated closely with advanced T stage, lymph node involvement, and distant metastasis, exhibiting a significant association with poorer overall survival among CRC patients. Subsequent investigations unveiled that SERPINH1 overexpression notably bolstered CRC cell proliferation, invasion, and migration in vitro , while conversely, SERPINH1 knockdown elicited the opposite effects. Gene set enrichment analysis underscored a correlation between SERPINH1 upregulation and genes associated with cell cycle regulation. Our findings underscored the capacity of heightened SERPINH1 levels to expedite G1/S phase cell cycle progression via phosphatidylinositol 3-kinase/AKT/mechanistic target of rapamycin pathway activation, thereby facilitating CRC cell invasion and migration.
CONCLUSION
These findings imply a crucial involvement of SERPINH1 in the advancement and escalation of CRC, potentially positioning it as a novel candidate for prognostic assessment and therapeutic intervention in CRC management.
Epigenetic silencing schlafen-11 sensitizes esophageal cancer to ATM inhibitor
Authors: Zhou Jing , Zhang Mei-Ying , Gao Ai-Ai , Zhu Cheng , He Tao , Herman James G , Guo Ming-Zhou 
Published: May 2024

BACKGROUND
Targeting DNA damage response (DDR) pathway is a cutting-edge strategy. It has been reported that Schlafen-11 (SLFN11) contributes to increase chemosensitivity by participating in DDR. However, the detailed mechanism is unclear.
AIM
To investigate the role of SLFN11 in DDR and the application of synthetic lethal in esophageal cancer with SLFN11 defects.
METHODS
To reach the purpose, eight esophageal squamous carcinoma cell lines, 142 esophageal dysplasia (ED) and 1007 primary esophageal squamous cell carcinoma (ESCC) samples and various techniques were utilized, including methylation-specific polymerase chain reaction, CRISPR/Cas9 technique, Western blot, colony formation assay, and xenograft mouse model.
RESULTS
Methylation of SLFN11 was exhibited in 9.15% of (13/142) ED and 25.62% of primary (258/1007) ESCC cases, and its expression was regulated by promoter region methylation. SLFN11 methylation was significantly associated with tumor differentiation and tumor size (both P < 0.05). However, no significant associations were observed between promoter region methylation and age, gender, smoking, alcohol consumption, TNM stage, or lymph node metastasis. Utilizing DNA damaged model induced by low dose cisplatin, SLFN11 was found to activate non-homologous end-joining and ATR/CHK1 signaling pathways, while inhibiting the ATM/CHK2 signaling pathway. Epigenetic silencing of SLFN11 was found to sensitize the ESCC cells to ATM inhibitor (AZD0156), both in vitro and in vivo .
CONCLUSION
SLFN11 is frequently methylated in human ESCC. Methylation of SLFN11 is sensitive marker of ATM inhibitor in ESCC.