bluuebunny/crossref_metadata_2025_split huggingface dataset:
A case of hemorrhage at the junctions of the posterior intercostal arteries—a vital sign?
Authors: Lange-Herr Nicolas , Tschui Joëlle , Klaus Jeremias , Baglivo Manuela , Schlottke Emilie , Zech Wolf-Dieter 
Published: June 2024

AbstractThe authors present the case of a 58-year-old man found hanging from a radiator by his shoelaces. The time of death was approximately 6 h before the body was discovered. An autopsy was performed approximately 24 h after the body was found, which revealed hemorrhages in the thoracic aorta at the junctions of the posterior intercostal arteries. Before autopsy, a routine whole-body CT scan was performed. Histologic examination of the aorta and the posterior intercostal arteries revealed a fresh hemorrhage into the tunica adventitia of the aorta. To our knowledge, there is no case description of such findings in hanged persons in the literature. Conclusion: Hemorrhages into the tunica adventitia of the junction of the posterior costal arteries may occur in association with suicidal hanging. The significance of these hemorrhages as a sign of vitality may be debated.
Unveiling the invisible: a qualitative interview study on the impact of young onset Parkinson’s disease on (ex-)partners
Authors: Kapelle Willanka Mariëlle , Geerlings Angelika D. , Mutsaers Inge , Bloem Bastiaan R. , Meinders Marjan J. , Post Bart 
Published: June 2024

Abstract
Introduction
Living with young onset Parkinson’s disease (YOPD) not only affects the persons with YOPD, but also their families. Although caregiver burden has been researched in Parkinson’s disease in general, little is known about the specific impact of having an (ex-)partner with YOPD. This exploratory study aimed to explore the impact of having an (ex-)partner with YOPD on daily life.

Materials and methods
We used a qualitative approach including semi-structured interviews with 16 (ex-)partners of people with YOPD. Interviews were audio-taped and transcribed verbatim. Qualitative thematic analysis was used to analyze the interview data.

Results
Qualitative analysis revealed nine themes to describe the impact of having an (ex-)partner with YOPD: (1) Psychosocial impact, (2) Impact on taking care of children, (3) Impact on working life, (4) Impact on intimacy and (sexual) relationships, (5) Impact on daily life, (6) Acceptance and other coping strategies, (7) Thoughts about the future, (8) Autonomy and (9) Caregiver support.

Discussion
This study provides important findings that will inform future interventions that aim to reduce or even prevent caregiver burden, as well as to inform healthcare professionals to recognize the needs of caregivers of people with YOPD.
Exploring the interplay between angiosperm chlorophyll metabolism and environmental factors
Authors: Yong Shunyuan , Chen Qian , Xu Fan , Fu Hao , Liang Guolu , Guo Qigao 
Published: June 2024

Abstract
Main conclusion
In this review, we summarize how chlorophyll metabolism in angiosperm is affected by the environmental factors: light, temperature, metal ions, water, oxygen, and altitude.

Abstract
The significance of chlorophyll (Chl) in plant leaf morphogenesis and photosynthesis cannot be overstated. Over time, researchers have made significant advancements in comprehending the biosynthetic pathway of Chl in angiosperms, along with the pivotal enzymes and genes involved in this process, particularly those related to heme synthesis and light-responsive mechanisms. Various environmental factors influence the stability of Chl content in angiosperms by modulating Chl metabolic pathways. Understanding the interplay between plants Chl metabolism and environmental factors has been a prominent research topic. This review mainly focuses on angiosperms, provides an overview of the regulatory mechanisms governing Chl metabolism, and the impact of environmental factors such as light, temperature, metal ions (iron and magnesium), water, oxygen, and altitude on Chl metabolism. Understanding these effects is crucial for comprehending and preserving the homeostasis of Chl metabolism.
Acute kidney injury development is associated with mortality in Japanese patients with cirrhosis: impact of amino acid imbalance
Authors: Miwa Takao , Utakata Yuki , Hanai Tatsunori , Aiba Masashi , Unome Shinji , Imai Kenji , Takai Koji , Shiraki Makoto , Katsumura Naoki , Shimizu Masahito 
Published: June 2024

Abstract
Background
Acute kidney injury (AKI) is a serious complication of cirrhosis. This study analyzed the prognostic effect of AKI in patients with cirrhosis and its risk factors, particularly in relation to amino acid imbalance.

Methods
This retrospective study reviewed 808 inpatients with cirrhosis at two institutes in Gifu, Japan. AKI was diagnosed according to the recommendations of the International Club of Ascites. Amino acid imbalance was assessed by measuring serum branched-chain amino acid (BCAA) levels, tyrosine levels, and the BCAA-to-tyrosine ratio (BTR). Factors associated with mortality and AKI development were assessed using the Cox proportional hazards regression model with AKI as a time-dependent covariate and the Fine–Gray competing risk regression model, respectively.

Results
Of the 567 eligible patients without AKI at baseline, 27% developed AKI and 25% died during a median follow-up period of 4.7 years. Using a time-dependent covariate, AKI development (hazard ratio [HR], 6.25; 95% confidence interval [CI], 3.98–9.80; p < 0.001) was associated with mortality in patients with cirrhosis independent of potential covariates. In addition, alcohol-associated/-related liver disease, metabolic dysfunction-associated steatohepatitis, Child–Pugh score, and BTR (subdistribution HR 0.78; 95% CI 0.63–0.96; p = 0.022) were independently associated with AKI development in patients with cirrhosis. Similar results were obtained in the multivariate model that included BCAA and tyrosine levels instead of BTR.

Conclusions
AKI is common and associated with mortality in Japanese patients with cirrhosis. An amino acid imbalance is strongly associated with the development of AKI in patients with cirrhosis.
Bemarituzumab plus mFOLFOX6 as first-line treatment in East Asian patients with FGFR2b-overexpressing locally advanced or metastatic gastric/gastroesophageal junction cancer: subgroup of FIGHT final analysis
Authors: Kang Yoon-Koo , Qin Shukui , Lee Keun-Wook , Oh Sang Cheul , Kim In-Ho , Kim Jong Gwang , Li Yong , Yan Zhuchen , Li Jin , Bai Li-Yuan , Chan Catherine , Yusuf Akeem , Zahlten-Kümeli Anita , Taylor Kate , Yamaguchi Kensei 
Published: June 2024

Abstract
Background
In the FIGHT study (NCT03694522) bemarituzumab, a humanized monoclonal antibody selective for fibroblast growth factor receptor 2b (FGFR2b), plus mFOLFOX6 showed clinically meaningful efficacy in patients with FGFR2b-positive (2+/3+ membranous staining by immunohistochemistry) locally advanced unresectable/metastatic gastric/gastroesophageal cancer (G/GEJC). A meaningful proportion of patients in FIGHT were enrolled in East Asia, reflecting global epidemiology of G/GEJC.

Methods
This subgroup analysis of the global, phase 2, double-blind FIGHT study included all patients enrolled in East Asian sites. Patients were randomized 1:1 to bemarituzumab-mFOLFOX6 (15 mg/kg and one 7.5 mg/kg dose on cycle 1, day 8) or matching placebo-mFOLFOX6. The primary endpoint was investigator-assessed progression-free survival (PFS). Secondary endpoints included overall survival (OS), objective response rate, and safety. Efficacy was evaluated after a minimum follow-up of 24 months.

Results
The East Asian subgroup comprised 89 patients (57% of overall study population); 45 were randomized to bemarituzumab-mFOLFOX6 and 44 to placebo-mFOLFOX6. Median PFS (95% confidence interval [CI]) was 12.9 months (8.8–17.9) with bemarituzumab-mFOLFOX6 and 8.2 months (5.6–10.3) with placebo-mFOLFOX6 (HR 0.50, 95% CI 0.29–0.87); median OS (95% CI) was 24.7 months (13.8–33.1) vs 12.9 months (9.3–21.4), respectively (HR 0.56, 95% CI 0.32–0.96). Treatment benefit was more pronounced in patients with FGFR2b-positive G/GEJC in ≥ 10% of tumor cells. No new safety signals were reported.

Conclusion
In East Asian patients with FGFR2b-positive advanced/metastatic G/GEJC enrolled in the global FIGHT study, bemarituzumab-mFOLFOX6 showed clinically meaningful outcomes over placebo-mFOLFOX6.
Is Time an Illusion? A Bootstrap Likelihood Ratio Test for Shock Transmission Delays in DSGE Models
Authors: Angelini Giovanni , Fanelli Luca , Sorge Marco M. 
Published: June 2024

AbstractSeveral business cycle models exhibit a recursive timing structure, which enforces delayed propagation of exogenous shocks driving short-run dynamics. We propose a bootstrap-based empirical strategy to test for the relevance of timing restrictions and ensuing shock transmission delays in DSGE environments. In the presence of strong identification, we document how likelihood-based tests in bootstrap-resamples can be used to empirically assess short-run restrictions placed by informational structures on a given model’s equilibrium representation, thereby enhancing coherence between theory and measurement. We evaluate the size properties of our procedure in short time series by conducting a number of numerical experiments on a popular New Keynesian model of the monetary transmission mechanism. An empirical application to U.S. data from the Great Moderation period allows us to revisit and qualify previous findings in the field by lending support to the conventional (unrestricted) timing protocol, whereby inflation and output gap do respond on impact to monetary policy innovations.
Experimental Investigation of Water-Based Fire Suppression Systems on External Façade Fires
Authors: Meraner Christoph , Skilbred Ellen S. , Arsava Kemal S. 
Published: June 2024

AbstractThe use of external fire suppression systems can reduce the risk of fire spreading between buildings. This study investigated the effectiveness and efficiency of different externally placed water-based fire suppression systems on façade fire safety. A series of large-scale experiments comprising an SP Fire 105 setup equipped with sprinklers and high-pressure water mist nozzles have been performed. A combustible façade, consisting of 2.5 cm thick oriented strand board (OSB) plates, was installed to provide challenging conditions and allow a visual assessment of the post-fire damage. The temperature profile on the façade surface was measured with 34 thermocouples, while five heat flux gauges and two fast-response plate thermocouples were used to measure the heat flux on the façade surface and emitted to the ambient. The sprinklers and the high-pressure water mist system effectively suppressed the upwards flame migration and reduced the heat flux toward adjacent buildings. It was observed that the sprinklers acted as a water curtain and kept the façade wet during the fire, promoting minor damage (the burnt area is less than 1% of the total area). The temperature and heat flux measurements demonstrated that the sprinkler system was the most effective suppression system. However, the high-pressure water mist systems achieved similar effectiveness but a much higher efficiency concerning water consumption. The sprinkler nozzles used four times as much water as the high-pressure water mist nozzles.
Novel sound event and sound activity detection framework based on intrinsic mode functions and deep learning
Authors: Hajihashemi Vahid , Alavigharahbagh Abdorreza , Machado J. J. M. , Tavares João Manuel R. S. 
Published: June 2024

AbstractThe detection of sound events has become increasingly important due to the development of signal processing methods, social media, and the need for automatic labeling methods in applications such as smart cities, navigation, and security systems. For example, in such applications, it is often important to detect sound events at different levels, such as the presence or absence of an event in the segment, or to specify the beginning and end of the sound event and its duration. This study proposes a method to reduce the feature dimensions of a Sound Event Detection (SED) system while maintaining the system’s efficiency. The proposed method, using Empirical Mode Decomposition (EMD), Intrinsic Mode Functions (IMFs), and extraction of locally regulated features from different IMFs of the signal, shows a promising performance relative to the conventional features of SED systems. In addition, the feature dimensions of the proposed method are much smaller than those of conventional methods. To prove the effectiveness of the proposed features in SED tasks, two segment-based approaches for event detection and sound activity detection were implemented using the suggested features, and their effectiveness was confirmed. Simulation results on the URBAN SED dataset showed that the proposed approach reduces the number of input features by more than 99% compared with state-of-the-art methods while maintaining accuracy. According to the obtained results, the proposed method is quite promising.
The long-run effects of recessions on fertility
Authors: Zimmer David M. 
Published: June 2024

AbstractUsing large repeated cross-sections and a cohort-based econometric approach, this paper produces evidence that women who finish their formal education during periods of high unemployment have significantly, and persistently, lower fertility compared to women who graduate during more favorable economic conditions. In terms of magnitude, a woman who graduates into a market with a 3 percentage point higher unemployment rate experiences an approximate 14% reduction in birth probabilities about a half-decade later. The long-recognized negative effects of unemployment on marriage explain, at most, 30% of that reduction in fertility. Rather, graduating into high unemployment appears to exert its own influence on fertility, separate from its effect on marriage.
A logical challenge to correlationism: the Church–Fitch paradox in Husserl’s account of fulfilment, truth, and meaning
Authors: Bös Gregor E. 
Published: June 2024

AbstractHusserl’s theory of fulfilment conceives of empty acts, such as symbolic thought, and fulfilling acts, such as sensory perceptions, in a strict parallel. This parallelism is the basis for Husserl’s semantics, epistemology, and conception of truth. It also entails that any true proposition can be known in principle, which Church and Fitch have shown to explode into the claim that every proposition is actually known. I assess this logical challenge and discuss a recent response by James Kinkaid. While Kinkaid’s proposal saves one direction of the parallel for semantics, it gives up the parallelism for truth. I spell out a different response which meshes naturally with Husserl’s account of meaning. If the parallelism is restricted to a class of basic propositions, the truth of non-basic propositions can be defined inductively, without leading to the paradox. I then discuss objections that have been raised against a similar proposal by Dummett. The result is that exegetically plausible and popular interpretations of Husserl’s correlationism are indeed challenged by Church and Fitch. But when taking into account the ‘logical adumbration’ of propositional blindspots, truth and possible fulfilment can be connected without paradox.
Analysis of the potential involvement of lncRNAs in embryogenic competence of Solanum betaceum Cav. (tamarillo) calli
Authors: Cordeiro Daniela , Camelo Alexandra , Pedrosa Ana Carolina , Brandão Inês , Santo Christophe Espírito , Canhoto Jorge , Correia Sandra 
Published: June 2024

AbstractSomatic embryogenesis (SE) is a process by which somatic cells reprogram, acquire totipotency and embark on embryo formation. Although SE is a valuable tool for micropropagation in many crops, it presents specific challenges in woody species due to some bottlenecks, such as loss of embryogenic competence during subcultures and the often-low somatic embryo conversion into plantlets. Hence, great interest exists in exploring the regulatory networks involved on SE. As transcription modulators, long non-coding RNAs (lncRNAs) have been found essential in a wide range of biological processes. This work aimed to identify lncRNAs related to the embryogenic competence in Solanum betaceum Cav. (tamarillo). Nanopore® long-read sequencing was conducted in cell lines with distinct cell fates and, based on their coding potential, 60 transcripts were selected as lncRNA candidates. Similar expression patterns were found among embryogenic cell lines (EC) and cells that lost their embryogenic potential (herein long-term callus, LTC), whereas non-EC (NEC) showed differentially expressed lncRNAs. Whereas lncRNAs upregulated in EC and LTC were predicted to target embryogenesis-related genes, such as AGAMOUS-like 15 and WUSCHEL-related HOMEOBOX 2, lncRNAs upregulated in NEC were predicted to target mainly genes involved in carbohydrate metabolism, cell wall formation, auxin and ethylene signalling pathways. Altogether, these results show the involvement of lncRNA in the process of somatic embryogenesis in S. betaceum, indicating that EC present a pattern of lncRNA expression that suggests its action on genes that directly modulate the morphogenic response in vitro, while in NEC the modulation through this type of RNAs seems to be predominantly reflected in genes more related to cellular physiology.
Graphical Abstract
Social Innovation and the Financial Risk of EMNCs - The Contingent Role of Institutional Legitimacy
Authors: Banna Hasanul , Mostafiz Md Imtiaz , Ahmed Farhad Uddin , Tarba Shlomo Y. 
Published: June 2024

AbstractThis paper examines the influence of social innovation on financial risk of emerging economy multinational corporations (EMNCs). Traditionally, research has focussed on Western MNCs’ and their financial performance implications. However, the growing involvement of EMNCs in social innovation—albeit in environments characterized by institutional voids—and its effects on financial risk necessitate an in-depth examination. Drawing on stakeholder theory, we explored how EMNCs balance their social innovation initiatives with financial risks. To this end, we first examine how social innovation reduces the financial risk of EMNCs. Second, we examine the association between excessive social innovation and EMNCs’ financial risk. In addition, borrowing insights from institutional theory, we assess the role played by institutional legitimacy in this process, acknowledging institutional legitimacy’s potential to mitigate the financial risks associated with social innovation in emerging economies. We test our hypotheses based on data drawn from 90 EMNCs in 14 emerging economies, applying a panel regression model with robust standard errors and a rigorous robustness propensity score matching test. Our findings show that social innovation reduces EMNC financial risk, and challenge the assertions made regarding the potential negative implications of excessive social innovation on financial risk. Our results also demonstrate the intricate moderating effects of institutional legitimacy in balancing social innovation, excessive social innovation, and EMNC financial risk. Finally, we proffer critical implications for managers and policymakers in emerging economies.
Height-diameter models for King Boris fir (Abies borisii regis Mattf.) and Scots pine (Pinus sylvestris L.) in Olympus and Pieria Mountains, Greece
Authors: Raptis Dimitrios I. , Papadopoulou Dimitra , Psarra Angeliki , Fallias Athanasios A. , Tsitsanis Aristides G. , Kazana Vassiliki 
Published: June 2024

AbstractIn forest science and practice, the total tree height is one of the basic morphometric attributes at the tree level and it has been closely linked with important stand attributes. In the current research, sixteen nonlinear functions for height prediction were tested in terms of their fitting ability against samples of Abies borisii regis and Pinus sylvestris trees from mountainous forests in central Greece. The fitting procedure was based on generalized nonlinear weighted regression. At the final stage, a five-quantile nonlinear height-diameter model was developed for both species through a quantile regression approach, to estimate the entire conditional distribution of tree height, enabling the evaluation of the diameter impact at various quantiles and providing a comprehensive understanding of the proposed relationship across the distribution. The results clearly showed that employing the diameter as the sole independent variable, the 3-parameter Hossfeld function and the 2-parameter Näslund function managed to explain approximately 84.0% and 81.7% of the total height variance in the case of King Boris fir and Scots pine species, respectively. Furthermore, the models exhibited low levels of error in both cases (2.310m for the fir and 3.004m for the pine), yielding unbiased predictions for both fir (−0.002m) and pine (−0.004m). Notably, all the required assumptions for homogeneity and normality of the associated residuals were achieved through the weighting procedure, while the quantile regression approach provided additional insights into the height-diameter allometry of the specific species. The proposed models can turn into valuable tools for operational forest management planning, particularly for wood production and conservation of mountainous forest ecosystems.
Stormwater runoff calculator for evaluation of low impact development practices at ground-mounted solar photovoltaic farms
Authors: Galzki Jake , Mulla David 
Published: June 2024

AbstractEstimating runoff at ground-mounted solar photovoltaic (PV) installations is challenging because of the disconnected nature of impervious solar panels and the pervious ground surface underneath and between panel rows. There is a need for improved tools to estimate how low impact development practices at these solar installations affect stormwater runoff. The objective of this study was to develop an innovative spreadsheet-based runoff calculator that rapidly estimates stormwater runoff from ground-mounted solar PV sites. The calculator is built on a 2-D hydrologic model (Hydrus-2D/3D) calibrated and validated using experimental data from five commercial solar farms in Colorado, Georgia, Minnesota, New York, and Oregon. The Hydrus-2D/3D hydrologic model was then used to generate nomographs for stormwater runoff that were incorporated into an easy-to-use Excel-based solar farm runoff calculator. This calculator allows for rapid estimation of NRCS stormwater runoff curve number (CN) values at solar farms by considering several complex factors unique to PV installations including: soil and topographic characteristics, surface cover, disconnected impervious surface factors associated with various solar panel designs, and climatic factors. The solar farm runoff calculator quickly estimates runoff CN for pre- and post-construction scenarios, and can estimate actual depth of runoff based on a user-specified 24-h design storm depth. Factors that have the most significant impact on stormwater runoff include design storm return frequency, soil texture, soil bulk density, and soil depth. Ground surface cover has a moderate impact on stormwater runoff, and factors that have a lesser impact on stormwater runoff include slope and array size, spacing and orientation on the landscape. The runoff calculator allows for accurate estimates of runoff generated by disconnected impervious surfaces and low impact development practices at solar farms as affected by a wide range of site-specific conditions.