bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluation of proximal tubular function in preterm infants by urinary α1‐microglobulin
Authors: TSUKAHARA HIROKAZU , HIRAOKA MASAHIRO , KURIYAMA MASANORI , HARUKI SHINICHI , NAKAMURA KATSUJI , SUEHIRO FUMIHIKO , SUDO MASAKATSU 
Published: January 2011

Abstractα1‐Microglobulin is a low molecular weight protein that is relatively stable in urine of low pH. There have been few reports on urinary α1‐microglobulin (U‐A1M) excretion in preterm infants. This study was designed to establish the ranges for U‐A1M in clinically stable preterm infants and to investigate changes observed in sick preterm infants. We measured U‐A1M and urinary β2‐microglobulin (U‐B2M) levels at 1, 4, 7, 14, 28 and 90 days after birth in stable preterm infants (Group 1) and sick preterm infants who were depressed at birth and required immediate resuscitation (Group 2). In Group 1 infants, both parameters were high during the first 28 days and appeared to decline thereafter. U‐A1M in Group 2 infants was only significantly increased compared with Group 1 on day 1, as was U‐B2M. On each day of the study, U‐A1M had significant positive correlations with U‐B2M for all the infants studied. The changes of the two parameters observed in Group 1 probably reflect postnatal evolution of proximal tubular function in stable preterm infants. A comparison of groups 1 and 2 shows a high prevalence of acute tubular injury at birth in sick infants and also suggests that U‐A1M as well as U‐B2M may be a sensitive index for detecting acute tubular damage and for following its course in preterm infants.
A longitudinal study of blood pressure, cholesterol and left ventricular muscle volume in children: The Shimane Heart Study
Authors: ABE KATSUTOSHI , NISHIO TOSHIKAZU , MORI CHUZO , HANEDA NORIYUKI , WATANABE KOJI 
Published: January 2011

AbstractThree hundred and forty‐four healthy schoolchildren living in Izumo City, Shimane Prefecture, Japan, were assessed at 3 year intervals from 6 to 15 years, starting in 1978 (Cohort 1) or 1981 (Cohort 2). Tracking indices (Ti) were calculated as follows: Ti = (2x + y ‐ z)/N/0.89, where x, y and z refer to the total number in the same, adjacent and remote trisections, respectively, and N = x + y + z. If Ti > 1, there is positive tracking. For systolic blood pressure (SBP) measurements (except at 6 years old) and serum cholesterol levels, all Ti were greater than 1.0 regardless of the time when tracking was commenced. Tracking indices were slightly greater in the serum cholesterol levels than in the SBP measurements. Left ventricular muscle volume indices (LVMVI) were calculated by echocardiographic measurements. In girls, the LVMVI was larger only in the above‐median SBP group at the age of 12 years (P < 0.01), but the LVMVI of the higher SBP (above median) group was larger than in the lower (below median) group at every age in boys; the difference was statistically significant (P < 0.05) at 12 and 15 years of age. Left ventricular mass enlargement may occur in the prehypertensive stage in humans as well as in rats.
Endoscopic ultrasonography in a child with chronic pancreatitis
Authors: KATO SEIICHI , FUJITA NAOTAKA , SHIBUYA HIDENORI , NAKAGAWA HIROSHI 
Published: January 2011

AbstractIn a case with chronic pancreatitis and pseudocysts related to muscular cytochrome—c oxidase deficiency, endoscopic ultrasonography (EUS) was performed to morphologically examine the pancreas for features that may have been missed by abdominal computed tomography and pancreatography. Conventional abdominal sonography had failed to show valuable diagnostic information of chronic pancreatitis in this case. EUS demonstrated several new findings. Parenchymal atrophy was remarkable, especially in the pancreatic tail, and a dilated pancreatic main or branch duct was clearly found in the region. Moreover, pancreatic stones in the main duct were also distinctly proved. EUS may become a useful new diagnostic method in pediatric gastroenterology, especially when sufficient findings are not obtained by conventional imaging techniques. However, an ultrasonographic endoscope with a shorter rigid portion and smaller caliber should be developed for pediatric patients.
Bile duct atresia following extended right hepatectomy because of a tumor
Authors: TAKEHARA HIROO , KOMI NOBUHIKO , OKADA AKIRA , MASAMUNE KATSUHIRO , ASAI AKIKO 
Published: January 2011

AbstractA 19 month old male infant with a mesenchymal hamartoma of the liver underwent an extended right hepatectomy. Serum bilirubin gradually rose until 3 months after the surgery, and obstructive jaundice and acholic stools were manifested at 6 months. Percutaneous transhepatic cholangiodrainage was performed. Cholangiography showed dilation of the intrahepatic bile duct of the residual lateral segment and complete obstruction of the extrahepatic bile duct. A second operation for reconstruction of the biliary tract was performed 10 months after the first surgery. No aspect of an extrahepatic biliary tract was found. Histological inspection of a surgical specimen of remnant tissue revealed only cicatricial connective tissue without any biliary structures. The clinical course has been uneventful for 18 months since the second surgery. The cause of bile duct atresia in this case is strongly suggested to be an ischemic change due to devascularization of the extrahepatic biliary tract following hepatic resection because of a tumor. To prevent this kind of complication, hepaticoenterostomy should be performed close to the cut surface of the liver.
A case of biliary stricture caused by cavernous transformation of the portal vein
Authors: TAKEHARA HIROO , KOMI NOBUHIKO , OKADA AKIRA , MASAMUNE KATSUHIRO , ASAI AKIKO 
Published: January 2011

AbstractA case is reported of extrahepatic obstruction of the portal vein with the unusual complication of obstructive jaundice that resulted from compression of the common bile duct caused by cavernous transformation of the varicose network. It is surgically impossible to repair choledochal stenosis resulting from enlarged varices in the vicinity of the common bile duct. In this case, internal drainage from the biliary duct to the duodenum using a silastic tube and a reservoir implanted in the subcutaneous space successfully eliminated the jaundice.
Role of a children's hospital safety centre in injury control
Authors: HANNAH LYNDA , NOLAN TERRY 
Published: January 2011

AbstractOver the past 13 years, child safety centres have been established at several Australian Children's hospitals. In a short time, they have developed an important role in community injury control programmes. These centres provide an efficient conduit for transferring up‐to‐date injury surveillance and prevention information to families, industry, health and education professionals, and government. The activities of the Child Safety Centre at the Royal Children's Hospital in Melbourne are described, together with ways in which a degree of self‐funding can be achieved.
Influence of long‐term carbamazepine treatment on thyroid function
Authors: YÜKSEL ADNAN , YALÇIN ERDINÇ , CENANİ ASIM 
Published: January 2011

AbstractWe have studied the effects of carbamazepine on thyroid function in sixteen recently diagnosed epileptic children and thirteen epileptic children receiving long‐term carbamazepine therapy and compared these findings with the thyroid function of thirteen healthy control subjects. Thyrotropin (TSH), tri‐iodothyronine (T3), thyroxine (T4), free tri‐iodothyorinine (FT3) and free thyroxine (FT4) serum levels were determined in both recently diagnosed but as yet untreated epileptic children and normal controls. These hormone levels were determined again after 2 months of treatment and 12 months of treatment in epileptic children. No statistically significant difference was found in the endocrine parameters of untreated epileptic children and the normal control group. After both 2 months and 12 months of carbamazepine therapy, serum levels of T4, FT4 and FT3 were found to be low, but the serum T3 concentration was unaffected. Baseline TSH levels were not changed during carbamazepine therapy either. Serum TSH levels increased rapidly after thyrotropin‐releasing hormone stimulation in both the before and 12 months after carbamazepine treatment groups, but the response was higher in the 12 months treatment group. The findings of the present study suggest that accelerated hormone metabolism is responsible for hormonal changes found in patients treated with carbamazepine. Carbamazepine also had effects on the function of the hypothalamo‐pituitary axis.
A new and rare form of Williams' syndrome
Authors: AKÇORAL ADNAN , ÖZAKSOY DINÇ , ORAN BÜLENT , NARIN NAZMI , ÇEVIK NECLA T. 
Published: January 2011

AbstractA 7 year old girl and her mother have typical phenotypic features of the Williams' (elfin facies) syndrome, and both have only mild mitral regurgitation with mitral valve prolapse (MVP). Mitral valve prolapse has been reported in only three cases but pure mitral insufficiency has not been reported alone. In this paper two cases of a new rare form of Williams' syndrome with MVP are presented and this rare disorder is discussed.
Chronic hypomagnesemia and hypokalemia due to renal wasting in siblings
Authors: IWATA FUJIHIKO , HANAWA YOSHIO , TAKASHIMA HIROTADA 
Published: January 2011

AbstractA 13 year old girl with carpopedal spasm is presented. Investigation values showed hypomagnesemia and hypokalemia. Her younger brother and sister demonstrated the same biochemical abnormalities without any symptoms. Their urinary excretion of magnesium and potassium were inappropriately high compared with their serum levels. Treatment with oral magnesium sulfate failed to correct the abnormalities, but serum levels of magnesium and potassium were just below the lower limits. This familial disease may represent congenital renal wasting of magnesium and potassium.
Levels of serum ferritin and total body iron among infants with different feeding regimens
Authors: HOKAMA TOMIKO 
Published: January 2011

AbstractThe levels of serum ferritin and total body iron of healthy infants were analyzed to evaluate iron status among infants with different feeding regimens. The results showed that the levels of serum ferritin and total body iron were lower in breast‐fed infants than in partially breast‐fed or formula‐fed infants at late infancy and 18 months of age.
Discriminant analysis of clinical tests in histologic diagnosis of renal disease
Authors: MASUTANI ATSUSHI , INOUE MAKOTO , MORI CHUZO 
Published: January 2011

AbstractWe have used discriminant analysis of the results of clinical examination to study whether or not it is possible to presume the histological findings of the kidney within the limits of the screening tests (urinalysis and blood tests) presently conducted at the outpatient clinic.A retrospective analysis was made of the data for 42 children who were found in school urine tests to have urinary abnormalities. Two discriminant functional equations were made and the overall rates of correct discrimination were ≥90%. Proteinuria, IgA and complement titer were selected. These results were considered useful in determining the indication for renal biopsy.
Prediction of engraftment after peripheral blood stem cell transplantation by CD34‐positive cells in grafts
Authors: URASHIMA MITSUYOSHI , UCHIYAMA HIROSHI , HOSHI YASUTAKA , DEGUCHI YASUSHI , KAMIJOU MAKOTO , KATOU YOUKO , FUJISAWA KOUJI , AKATSUKA JUN‐ICHI , MAEKAWA KIHEI 
Published: January 2011

Abstracttotal of 91 peripheral blood stem cell collections were performed in 26 children with various malignant tumors and peripheral blood stem cell transplantations (PBSCT) were performed in 15 of the children. There was a positive correlation between logarithm of total CD34+ cells/kg and logarithm of colony‐forming unit‐granulocyte macrophage (CFU‐GM)/kg (r = 0.86). The time elapsed until the white blood cells (WBC) exceeded 1000/μL was related to both CFU‐GM (r = 0.67) and CD34+ cell count (r = 0.60). The number of days elapsed until platelet count exceeded 5 times 104/μL was not related to the logarithm of CFU‐GM count/105 per kg transfused (r = 0.47), but was related to the logarithm of CD34+ cell counts/106 per kg transfused (r = 0.73). The number of days elapsed until the reticulocytes exceeded 5 times 104/μL was not related to the logarithm of CFU‐GM count/105 per kg (r = 0.52), but was related to the logarithm of CD34+ cell counts/106 per kg transfused (r = 0.91). Although CD34+ cell counts correlated with the number of CFU‐GM, bone marrow regeneration rates in three lineages were predicted more accurately by the number of CD34+ cells transfused than by the number of CFU‐GM. These results suggest that measurement of the CD34+ cell count may be useful in predicting bone marrow regeneration rate after PBSCT.
Partial trisomy for short arm of chromosome 5
Authors: YASUTOMO KOJI , SUZUE TAKESHI , NISHIOKA ATSUKO , KOZAN HIROKO , SEKIGUCHI TAKANORI , OHARA KATSUAKI , OKAMOTO TAKASHI , IWAI TSUYAKO , ENDO SHOICHI 
Published: January 2011

AbstractWe present two unrelated cases of partial trisomy for the short arm of chromosome 5, the first such cases reported in Japan. The features are characterized by hypertelorism, low set ears, arachnodactyly, laryngostenosis, hypotonia and some cerebral malformation. The characteristic facial expression and arachnodactyly are the key features used to diagnose this disorder.A high‐resolution chromosome banding technique showed that the karyotype of the first patient was 46, XX, inv dup(5) (p13.1 ← p15.3) de novo and that of the second patient was 46, XX, dir dup(5) (p13.3 ← p15.2) de novo. The similar symptoms in the two cases, despite the difference in karyotypes, were caused by duplication of 5p including segment 5p13. This would be a key site for this disorder.
Varicella‐zoster virus replication site in internal organs of an otherwise healthy child with varicella and sudden death
Authors: ASANO YOSHIZO , YOSHIKAWA TETSUSHI , URISU ATSUO , YAZAKI TAKEHIKO , MIZOGUCHI YOSHIKAZU , KURATA TAKESHI 
Published: January 2011

AbstractPathological findings of an otherwise healthy 17 month old boy who was exposed to Varicella‐zoster virus (VZV) in his family and unexpectedly died 3 days after onset of varicella are reported. They showed a disseminated VZV infection with involvement of skin, lung, liver, spleen, gastrointestinal tract and other organs where VZV antigen was detected by the enzyme‐immunoassay with monoclonal antibodies to VZV. Since the subject was the full‐term product of an uncomplicated pregnancy, who grew and developed normally, and had no symptoms or laboratory findings suggestive of immunodeficiency until his death, these findings suggest that many organs are involved as major internal sites of viral replication before or during infection of skin with VZV in the immunocompetent host.
Moyamoya disease associated with bilateral renal artery stenosis
Authors: NAKANO TAKASHI , AZUMA EIICHI , IDO MASARU , ITOH MASAHIRO , SAKURAI MINORU , SUGA SHIGERU , KAWAGUCHI HIROSHI 
Published: January 2011

AbstractRecent research has suggested that an association exists between moyamoya disease and fibromuscular dysplasia which involves systemic vessels, including renal arteries. We report a 3 year old girl with moyamoya disease associated with bilateral renal artery stenosis. This case may support the common etiology of these two clinical conditions. To our knowledge this is the youngest case of moyamoya disease associated with bilateral renal artery stenosis.
Megacystis and megacolon in an infant with Ehlers‐Danlos syndrome
Authors: SATO TADASHI , ITO HIROYUKI , MIYAZAKI SUMIO , KOMINE SHINICHIRO , HAYASHIDA YUTAKA 
Published: January 2011

AbstractWe report a 14 month old male infant with Ehlers‐Danlos syndrome who became ‘anuric’ due to an acutely dilated urinary bladder. Although the patient was also found to have megacolon, no diverticulum was seen in his gastrointestinal tract or urinary bladder. In order to decompress the urinary bladder and colonic wall, we put an indwelling urinary catheter in place for 2 months, and carried out daily glycerin enema for 3 months. All urological and gastrointestinal symptoms subsided with this intensive medical treatment. The diagnosis of megacystis and megacolon was made very early in life for this patient. This may indicate that the striking extension of gastrointestinal and bladder wall may lead to the development of diverticula of gastrointestinal and urinary tracts in later life.
Screening for growth hormone deficiency using urinary growth hormone measurement
Authors: KUBOTA AKIRA , OGAWA HARUO , IGARASHI YOSHIO , MIZUNO YOSHIHITO , TANIGUCHI KAZUTOSHI 
Published: January 2011

AbstractThe diagnostic approach in growth hormone deficiency (GHD) is complicated. Two or more provocative tests are essential for definitive diagnosis of GHD. However, such testing cannot be carried out routinely on all subjects with short stature because of the need for hospitalization and blood sampling. A simple screening method for GHD would be of great value. Human growth hormone (hGH) levels were measured in the early morning urine of 192 children aged 7–15 years with height 2.0 s.d. below the mean for their ages. Sixty‐eight subjects were selected because they showed a urinary hGH level < 10 ng/g creatinine. They were further examined in terms of bone age and plasma insulin‐like growth factor (IGF‐I) levels. In 30 subjects, the ratio of bone age: chronological age was < 0.8 and/or plasma IGF‐I level was < 0.7 U/mL.Finally 24 of these subjects were examined with provocative tests and other endocrinological tests. Eleven subjects proved to have poor growth hormone secretion and one subject was diagnosed as having Turner syndrome.In conclusion, 11 patients with GHD were diagnosed from 192 children with short stature using urinary hGH measurement as the first screening method. These findings suggests that urinary hGH measurement could be a useful and simple method for detecting GHD.
Virological and serological studies on poliomyelitis in Karachi, Pakistan. I. Outbreaks in 1990‐91
Authors: ISOMURA SHIN , MUBINA AGBOATWALLA , DURE‐SAMIN AKRAM , ISIHARA YUICHI , SAKAE KENJI , YAMASHITA TERUO , NISHIO OSAMU , AHMED AKHTAR 
Published: January 2011

AbstractBetween October 1989 and September 1991, 124 cases of poliomyelitis visited the Department of Paediatrics, Civil Hospital Karachi, Pakistan. The majority of them were between 6 months and 2 years of age and the epidemics occurred during the hot seasons. The dominant serotype was poliovirus type 1 during the epidemic season in 1990 and type 2 in 1991. All the polioviruses isolated from the patients were wild‐type. Virological studies also disclosed that enteroviruses other than polioviruses were prevalent among healthy children as well as among diarrheal and polio patients.A serological survey to elucidate the serological efficacy of oral polio vaccine (OPV) showed that: (i) in 112 unimmunized children, after disappearance of transplacental maternal antibody during early infancy, antibody prevalence increased gradually and > 80% of the children were seropositive against all three types of polioviruses at 5 years of age; (ii) in 201 children immunized with full doses of OPV in their infancy, the decrease in antibody titer during infancy was less and seroprevalence rose sharply afterwards: at 2 years of age, > 80% of them were seropositive against all three types of the virus. The rapid increase of seroprevalence might be the effect of OPV administration. However, the prevalence was lower than that in developed countries.
Bone marrow transplantation for late infantile metachromatic leukodystrophy: Pathogenic investigation for graft rejection
Authors: NAGAI TOSHIRO , KANEKO TAKASHI , SHICHIJOU HIROMI , KARATO TAKAKO , MARUYAMA AKIKO , TSUCHIYA YUTAKA 
Published: January 2011

AbstractA Japanese boy aged 2 years 11 months with late infantile metachromatic leukodystrophy underwent bone marrow transplantation (BMT) from his human leukocyte antigen (HLA) identical but mixed lymphocyte culture reactive father. Chimerism and increased arylsulfatase A activities of leukocytes had been observed with retarded progression of neurological deterioration during the first 3 months post‐BMT. Graft rejection gradually occurred and donor cells were almost completely eliminated from the patient at 1 year after BMT. The process of neurodegeneration progressed clinically and neuroradiologically. Three possible reasons for the pathogenesis of graft rejection are: (i) T cell depletion of donor marrow cells as graft‐versus‐host disease (GVHD) prophylaxis; (ii) a slightly weak conditioning regimen; and (iii) a small number of marrow cells transplanted. It is stressed that as BMT is still a preliminary therapy for metachromatic leukodystrophy indications, conditioning, and GVHD prophylaxis for BMT should be considered individually.
Asymptomatic Becker muscular dystrophy: Histological changes in biopsied muscles
Authors: TACHI NOBUTADA , WATANABE YUKIE , OHYA KAZUHIRO , CHIBA SHUNZO 
Published: January 2011

AbstractThe histological changes observed in consecutive tests of biopsied muscles from an asymptomatic patient with Becker muscular dystrophy (BMD) are reported. The first biopsy showed active muscle necrosis and clustered regenerating fibers. The second biopsy revealed chronic myopathic changes mixed with neurogenic involvement. It is stressed that active myogenic changes observed in younger and asymptomatic BMD patients were followed by chronic myogenic or neurogenic change with age. Finally, we confirm the necessity of checking for dystrophin of abnormal size or reduced abundance by immunoblot analysis.
Estimation of myocardial damage in Kawasaki disease using antimyosin antibody
Authors: NOMURA YUICHI , YOSHINAGA MASAO , OKU SHOZO , KONO YUKIHARU , YUASA YOSHIHIRO , NODA TAKASHI 
Published: January 2011

AbstractIn a retrospective study, 121 children with Kawasaki disease (KD) were investigated to determine (i) the incidence of myocardial damage using the antimyosin antibody (AMA) titer; (ii) the differences in the electrocardiograms between the AMA‐positive and ‐negative patients; and (iii) the effect of treatment with intravenous gamma globulin (IVGG) on the AMA. Comparisons were made with 117 normal children (controls).Patients with KD showed a significantly higher mean AMA titer and more patients were positive for AMA than the controls. The AMA titer in the KD group was not related to the presence of coronary artery lesions. Electrocardiograms obtained during the acute and the convalescent stage of KD revealed that patients positive for AMA had a significantly lower voltage of T wave in lead V6 at week four than at week two of illness, whereas patients negative for AMA showed no T wave change after week two. The group treated with IVGG showed a significantly lower AMA titer than that not given IVGG.These observations suggest that myocardial damage occurs in some patients with KD which is unrelated to the presence of coronary artery lesions and that the treatment with IVGG reduces the AMA titer in patients with KD.
Stroke and meningitis in a case of SLE with anti‐phospholipid antibodies
Authors: WATANABE TOHRU , SATOH MASAHISA , ABE TOKINARI , HAYASHI MIWAKO , ODA YOSHIHIKO 
Published: January 2011

AbstractAnti‐phospholipid antibodies (aPL) are concerned with many central nervous system diseases in systemic lupus erythematosus (SLE). However, no report has described the relationship between aseptic meningitis and aPL in SLE. We report a case of SLE with aPL, presenting cerebral infarction and aseptic meningitis.A 14 year old female with SLE with aPL experienced cerebral infarction and recurrent aseptic meningitis. Combination therapy with steroids and aspirin improved the condition and prevented relapses.The aPL are associated with cerebral infarction, even in young patients with SLE. In addition, aPL may induce aseptic meningitis in SLE.