bluuebunny/crossref_metadata_2025_split huggingface dataset:
Long-term follow-up of a randomized clinical trial of open versus laparoscopic appendicectomy
Authors: Kouhia S T , Heiskanen J T , Huttunen R , Ahtola H I , Kiviniemi V V , Hakala T 
Published: July 2010

Abstract

Background
The aim of this study was to assess long-term outcome following open versus laparoscopic appendicectomy.

Methods
A total of 105 patients with suspected acute appendicitis were randomized to LA (51) or OA (54) between 1997 and 1999 at one hospital. Perioperative factors and follow-up data from the outpatient clinic were recorded. Information about symptoms and overall satisfaction was obtained by telephone interview. In addition, appendicectomy data for 2008 were analysed retrospectively for comparison in a contemporary setting.

Results
Data from 52 patients who had OA and 47 who had LA were analysed. OA was performed mostly by trainees, but LA was more likely to be undertaken by a consultant. The open procedure was quicker than the laparoscopic operation in the trial period (median 38 versus 65 min respectively; P &lt; 0·001), but the difference was only 10 min in 2008. The OA group returned to work later than the LA group (median 13 versus 8 days; P = 0·013) and had more complications (22 versus 6; P = 0·014). Only one patient (OA) had a reoperation, owing to abdominal adhesions. Among 76 patients available for telephone interview, satisfaction scores were marginally higher for LA than OA.

Conclusion
LA has some advantages compared with an open approach. Registration number: NCT00908804 (http://www.clinicaltrials.gov).
Thoracic paravertebral spread using two different ultrasound‐guided intercostal injection techniques in human cadavers
Authors: Paraskeuopoulos Tilemachos , Saranteas Theodosios , Kouladouros Konstantinos , Krepi Heleni , Nakou Mariza , Kostopanagiotou Georgia , Anagnostopoulou Sophia 
Published: July 2010

AbstractThe continuity between the intercostal and paravertebral space has been established by several studies. In this study, the paravertebral spread of a colored dye was attempted with two different ultrasound‐guided techniques. The posterior area of the trunk was scanned with a linear probe between the level of the fifth and the seventh thoracic vertebrae in eleven embalmed human cadavers. In the first technique, the probe was placed transversely below the inferior margin of the rib, and a needle was inserted between the internal intercostal membrane and the pleura. In the second technique, the probe was placed longitudinally at the intercostal space 5 cm lateral to the spinous processes, and the needle was inserted between the internal intercostal membrane and the pleura. In both techniques, 1 ml of methylene blue was injected, and both the intercostal and paravertebral spaces were prepared. In total, 33 injections were performed: 19 with the transverse technique and 14 with the longitudinal technique. Successful spread of the dye to the thoracic paravertebral space was recorded in 89.5% cases using the transverse technique and 92.8% cases using the longitudinal technique. No intrapleural spread of the dye was recorded in either technique. Ultrasound‐guided injection into the intercostal space may offer an alternative approach to the thoracic paravertebral space. Clin. Anat. 23:840–847, 2010. © 2010 Wiley‐Liss, Inc.
Facets on the psychopathy checklist screening version and instrumental violence in forensic psychiatric patients
Authors: Laurell Jenny , Belfrage Henrik , Hellström Åke 
Published: July 2010

AbstractBackground There is a recognised relationship between psychopathy and instrumental violence, but not all violence by people who meet the criteria for psychopathy is instrumental.Aims Our aims were to compare offence types among forensic psychiatric patients with and without the Psychopathy Checklist: Screening Version (PCL: SV) criteria for psychopathy. Our specific questions were whether factor 1 – the interpersonal affective dimension – was related to instrumentality and on severity of the violent crime. Our hypothesis was that the relationship between psychopathy and instrumental violence would be dependent on the severity of the violent crime.Methods Sixty‐five male patients at the forensic psychiatric hospital in Sundsvall, all with a violent criminal history, were assessed for psychopathy through interview and records using the PCL: SV. Severity and the instrumentality of their previous violence were coded using the Cornell coding guide for violent incidents.Results The interpersonal features of psychopathy (the interpersonal facet), and only the interpersonal features were significantly associated with instrumentality and severity of violence. Instrumentality was also significantly related to the severity of the violence, independent of psychopathy score.Conclusions The results indicated that, at least among forensic psychiatric patients, planning is more likely than not with respect to serious crimes. The specific link between interpersonal features of psychopathy and instrumental and severe violence suggests potential clinical value in recognising subtypes of psychopathy. Copyright © 2010 John Wiley & Sons, Ltd.
Extraction of Oxidized Sulfur‐Containing Compounds of Non‐Hydrotreated Gas Oil
Authors: Sobati M. A. , Dehkordi A. M. , Shahrokhi M. 
Published: July 2010

AbstractThe desulfurization of non‐hydrotreated gas oil using oxidation followed by liquid/liquid extraction has been studied. The solvent extraction of oxidized sulfur‐containing compounds of gas oil was carried out by utilizing various types of solvents, including acetonitrile, methanol, and 96 vol.‐% ethanol. The performance of these solvents was carefully evaluated and compared by considering both desulfurization and gas oil recovery. It was found that their performance follows the order: acetonitrile > methanol > 96 vol.‐% ethanol. The influences of operating conditions, such as number of extraction stages and solvent to gas oil ratio, on the desulfurization and recovery of gas oil, were investigated. Over 99 % desulfurization of gas oil was achieved after liquid/liquid extraction of the oxidized sulfur‐containing compounds.
Cyclopolymerization and Copolymerization of Functionalized 1,6‐Heptadienes Catalyzed by Pd Complexes: Mechanism and Application to Physical‐Gel Formation
Authors: Park Sehoon , Okada Takeshi , Takeuchi Daisuke , Osakada Kohtaro 
Published: July 2010

AbstractCationic Pd complexes, prepared from [PdCl(ArNC12H6NAr)(Me)] and Na[B{3,5(CF3)2C6H3}4] (NaBARF), catalyze the cyclopolymerization of 4,4‐disubstituted 1,6‐heptadienes. The polymers produced contain a trans‐fused five‐membered ring in each repeating unit. NMR spectroscopy and FAB mass spectrometry of the polymers formed indicated that the initiation end of the chain contains either the cyclopentyl group derived from the preformed Pd–monomer complex or a hydrogen atom left on the Pd center by the chain‐transfer reaction. The stable cyclopentylpalladium species are involved in both initiation and propagation steps and undergo isomerization into (cyclopentylmethyl)palladium species followed by the insertion of a CHCH2 bond of a new monomer molecule into the PdCH2 bond. Copolymerization of 1,6‐heptadiene derivatives with ethylene, catalyzed by the Pd complexes, yields polymers that contain trans five‐membered rings and branched oligoethylene units. Copolymerization of isopropylidene diallylmalonate with 1‐hexene affords a polymer with 26 % diene incorporation. The copolymerization consumes 1‐hexene more readily than isopropylidene diallylmalonate, although gel permeation chromatography and NMR spectroscopy of the polymers produced show the formation of copolymers rather than of a mixture of homopolymers. Polymerization of 1‐hexene initiated with a Pd–barbiturate complex and terminated with 5‐allyl‐5‐hexylpyrimidine‐2,4,6(1H,3H,5H)‐trione/Et3SiH leads to polyhexene with barbiturate moieties at both terminal ends. Addition of 5‐hexyl‐2,4,6‐triaminopyrimidine to a toluene solution of the telechelic poly(1‐hexene) converts the solution into gel.
ChemInform Abstract: Fries Rearrangement of Esters in Montmorillonite Clays: Steric Control on Selectivity.
Authors: VENKATACHALAPATHY C. , PITCHUMANI K. 
Published: July 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: A Novel Synthesis of 2‐Hydroxymethyl‐3‐phenyl‐1,4‐benzodioxanes.
Authors: GANESH T. , KRUPADANAM G. L. D. 
Published: July 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Palladium‐Complex‐Catalyzed Cyanation of Allylic Carbonates and Acetates Using Trimethylsilyl Cyanide.
Authors: TSUJI Y. , KUSUI T. , KOJIMA T. , SUGIURA Y. , YAMADA N. , TANAKA S. , EBIHARA M. , KAWAMURA T. 
Published: July 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Microwave Assisted Oxidation of Aromatic Aldehydes.
Authors: Reddy D. Sahadeva , Reddy P. Pratap , Reddy P. S. N. 
Published: July 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Antibiotic Resistance versus Small Molecules, the Chemical Evolution
Authors: Lee Ving J. , Hecker Scott J. 
Published: July 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: A New Hydrindanone Synthesis.
Authors: Curini Massimo , Epifano Francesco , Marcotullio Maria Carla , Rosati Ornelio , Guan Yousheng , Wenkert Ernest 
Published: July 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: First Asymmetric Synthesis of 3‐Methyltetrahydroquinolin‐4‐ones from Anilines.
Authors: Baraznenok Ivan L. , Nenajdenko Valentine G. , Churakov Andrei V. , Nesterenko Pavel N. , Balenkova Elizabeth S. 
Published: July 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Yb3F4S2: A Mixed‐Valent Ytterbium Fluoride Sulfide According to YbF2×2YbFS.
Authors: Schleid Thomas 
Published: July 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Bicyclic Derivatives of the Potent Dual Aromatase–Steroid Sulfatase Inhibitor 2‐Bromo‐4‐{[(4‐cyanophenyl)(4H‐1,2,4‐triazol‐4‐yl)amino]methyl}phenylsulfamate: Synthesis, SAR, Crystal Structure, and in vitro and in vivo Activities
Authors: Wood Paul M. , Woo L. W. Lawrence , Labrosse Jean‐Robert , Thomas Mark P. , Mahon Mary F. , Chander Surinder K. , Purohit Atul , Reed Michael J. , Potter Barry V. L. 
Published: July 2010

AbstractThe design and synthesis of a series of bicyclic ring containing dual aromatase–sulfatase inhibitors (DASIs) based on the aromatase inhibitor (AI) 4‐[(4‐bromobenzyl)(4H‐1,2,4‐triazol‐4‐yl)amino]benzonitrile are reported. Biological evaluation with JEG‐3 cells revealed structure–activity relationships. The X‐ray crystal structure of sulfamate 23 was determined, and selected compounds were docked into the aromatase and steroid sulfatase (STS) crystal structures. In the sulfamate‐containing series, compounds containing a naphthalene ring are both the most potent AI (39, IC50 AROM=0.25 nM) and the best STS inhibitor (31, IC50 STS=26 nM). The most promising DASI is 39 (IC50 AROM=0.25 nM, IC50 STS=205 nM), and this was evaluated orally in vivo at 10 mg kg−1, showing potent inhibition of aromatase (93 %) and STS (93 %) after 3 h. Potent aromatase and STS inhibition can thus be achieved with a DASI containing a bicyclic ring system; development of such a DASI could provide an attractive new option for the treatment of hormone‐dependent breast cancer.
Crystal Chemistry and Physical Properties of the Nonmagnetic Kondo Compound HfAs1.7Se0.2
Authors: Czulucki Andreas , Auffermann Gudrun , Bednarski Michal , Bochenek Łukasz , Böhme Maik , Cichorek Tomasz , Niewa Rainer , Oeschler Niels , Schmidt Marcus , Steglich Frank , Kniep Rüdiger 
Published: July 2010

AbstractSingle crystals of HfAs1.7Se0.2 are grown by chemical transport reaction and their chemical composition characterized in detail by various analytical methods. Chemical analyses and crystal structure investigations by single‐crystal X‐ray diffraction as well as powder diffraction with synchrotron radiation reveal a tetragonal PbFCl structure type with strong disorder caused by a significant arsenic deficiency (As0.9) on the 2a site and mixed occupancy of the 2c site (As0.8Se0.2). HfAs1.7Se0.2 is a diamagnetic metal which transforms into a superconducting state at Tc=0.52 K. Similar to other PbFCl‐type arsenide selenides, the title compound displays a magnetic‐field‐independent −AT1/2 term in the low‐temperature electrical resistivity. This unusual term presumably originates from the electron scattering of structural two‐level systems. According to the experimental results, HfAs1.7Se0.2 appears to be a rare example of a nonmagnetic Kondo material.
Calculation of the Vibrationally Resolved, Circularly Polarized Luminescence of d‐Camphorquinone and (S,S)‐trans‐β‐Hydrindanone
Authors: Pritchard Benjamin , Autschbach Jochen 
Published: July 2010

AbstractCircularly polarized luminescence (CPL), the differential emission of left‐ and right‐handed circularly polarized light from a molecule, is modeled by using time‐dependent density functional theory. Calculations of the CPL spectra for the first electronic excited states of d‐camphorquinone and (S,S)‐trans‐β‐hydrindanone under the Franck–Condon approximation and using various functionals are presented, as well as calculations of absorption, emission, and circular dichroism spectra. The functionals B3LYP, BHLYP, and CAM‐B3LYP are employed, along with the TZVP and aug‐cc‐pVDZ Gaussian‐type basis sets. For the lowest‐energy transitions, all functionals and basis sets perform comparably, with the long‐range‐corrected CAM‐B3LYP better reproducing the excitation energy of camphorquinone but leading to a blue shift with respect to experiment for hydrindanone. The vibrationally resolved spectra of camphorquinone are very well reproduced in terms of peak location, widths, shapes, and intensities. The spectra of hydrindanone are well reproduced in terms of overall envelope shape and width, as well as the lack of prominent vibrational structure in the emission and CPL spectra. Overall the simulated spectra compare well with experiment, and reproduce the band shapes, emission red shifts, and presence or absence of visible vibrational fine structure.
Cardiac malformations in Pdgfrα mutant embryos are associated with increased expression of WT1 and Nkx2.5 in the second heart field
Authors: Bax Noortje A.M. , Bleyl Steven B. , Gallini Radiosa , Wisse Lambertus J. , Hunter Jennifer , Van Oorschot Angelique A.M. , Mahtab Edris A.F. , Lie‐Venema Heleen , Goumans Marie‐Jose , Betsholtz Christer , Gittenberger‐de Groot Adriana C. 
Published: July 2010

AbstractPlatelet‐derived growth factor receptor alpha (Pdgfrα) identifies cardiac progenitor cells in the posterior part of the second heart field. We aim to elucidate the role of Pdgfrα in this region. Hearts of Pdgfrα‐deficient mouse embryos (E9.5–E14.5) showed cardiac malformations consisting of atrial and sinus venosus myocardium hypoplasia, including venous valves and sinoatrial node. In vivo staining for Nkx2.5 showed increased myocardial expression in Pdgfrα mutants, confirmed by Western blot analysis. Due to hypoplasia of the primary atrial septum, mesenchymal cap, and dorsal mesenchymal protrusion, the atrioventricular septal complex failed to fuse. Impaired epicardial development and severe blebbing coincided with diminished migration of epicardium‐derived cells and myocardial thinning, which could be linked to increased WT1 and altered α4‐integrin expression. Our data provide novel insight for a possible role for Pdgfrα in transduction pathways that lead to repression of Nkx2.5 and WT1 during development of posterior heart field–derived cardiac structures. Developmental Dynamics 239:2307–2317, 2010. © 2010 Wiley‐Liss, Inc.
What do we still need to know about the ecohydrology of riparian zones?
Authors: Burt Tim , Pinay Gilles , Sabater Sergi 
Published: July 2010

AbstractRiparian zones have become increasingly important elements of river basin ecohydrology given their relevance of nutrient dynamics to water quality management. Most attention has been given to nitrogen cycling, denitrification in particular, but new processes have emerged as potentially important and need to be evaluated. Riparian zones are sensitive locations, so it is important to understand the impact of changes that can fundamentally alter their ecosystem processes and responses. Better understanding of how riparian buffering varies in time and space provides the basis for a catchment‐scale approach, but it seems likely that low‐order basins will remain the focus for research and management, given that low‐order basins constitute the majority of basin area. Finally, it is argued that new ecohydrological indicators are needed that combine innovative biogeochemical parameters and landscape connectivity measures. Copyright © 2010 John Wiley & Sons, Ltd.
Iron(II) Spin‐Transition Complexes with Dendritic Ligands, Part II
Authors: Wei YongLi , Sonar Prashant , Grunert Matthias , Kusz Joachim , Schlüter A. Dieter , Gütlich Philipp 
Published: July 2010

AbstractThe dendritic triazole‐based complexes [Fe(G1‐BOC)3](triflate)2·xH2O (1; G1‐BOC = tert‐butyl {3‐[3‐(3‐tert‐butoxycarbonylaminopropyl)‐5‐([1,2,4]triazol‐4‐ylcarbamoyl)phenyl]propyl}carbamate, triflate = CF3SO3–), [Fe(G1‐BOC)3](tosylate)2·xH2O (2; tosylate = p‐CH3PhSO3–), [Fe(G1‐DPBE)3](triflate)2·xH2O {3; G1‐DPBE = 3,5‐bis(3,5‐didodecaoxybenzyloxy)‐N‐[1,2,4]triazol‐4‐ylbenzamide}, [Fe(G1‐DPBE)3](tosylate)2·xH2O (4) and [Fe(G1‐DPBE)3](BF4)2·xH2O (5) were designed and synthesized. Magnetic and thermal properties of these novel complexes were characterized by magnetic susceptibility measurements, 57Fe Mössbauer spectroscopy and thermogravimetric analysis or differential scanning calorimetry, respectively. All dendritic complexes under study show different spin‐transition behaviour with respect to the nature of different dendritic ligands and counteranions. Complexes 1 and 2 have pronounced effects of a spin‐state change during the first heating process and gradual spin‐transition properties for further temperature treatments, whereas 3 and 4 exhibited a very sharp spin‐state change in the first heating procedures. Complex 5 showed a gradual spin‐transition curve. In this paper, we report how themagnetic properties of these complexes are correlated with noncoordinated water molecules and their effects on spin states.
Chemo‐, Regio‐ and Stereospecific Synthesis of Unnatural, Fluorescent Amino Acids by Condensation of L‐Lysine and 1‐Vinylpyrrole‐2‐carbaldehydes
Authors: Ivanov Andrey V. , Ushakov Igor A. , Petrushenko Konstantin B. , Mikhaleva Al'bina I. , Trofimov Boris A. 
Published: July 2010

AbstractA new family of unnatural, optically active amino acids containing the pyrrole moiety have been synthesized by condensation of 1‐vinylpyrrole‐2‐carbaldehydes with L‐lysine under mild conditions (EtOH, room temp., 2.5–3 h, 0.5 wt.‐% of CF3CO2H) in up to 90 % yields. Unlike non‐vinylated analogues, 1‐vinylpyrrole‐2‐carbaldehydes react chemo‐, regio‐ and stereospecifically with an ϵ‐amino group only to afford products of exclusively (E) configuration. The amino acids synthesized containing aromatic or condensed aromatic substitutents in the pyrrole ring fluoresce in the UV/Vis region (λmax = 350–382 nm, Stokes shifts 6150–7800 cm–1).
3‐Alkenyl‐oxindoles: Natural Products, Pharmaceuticals, and Recent Synthetic Advances in Tandem/Telescoped Approaches
Authors: Millemaggi Alessia , Taylor Richard J. K. 
Published: July 2010

AbstractThe structures and biological activities of naturally occurring 3‐alkenyl‐oxindoles are reviewed. Important man‐made3‐alkenyl‐oxindoles are covered, particularly those with pharmaceutical applications such as sunitinib (SU11248), the orally active receptor tyrosine kinase inhibitor marketed by Pfizer as Sutent®. Traditional synthetic approaches to 3‐alkenyl‐oxindoles are summarised and then recently developed tandem/telescoped synthetic routes are described.
Enantiomerically Pure and Highly Substituted Alicyclic α,α‐Difluoro Ketones: Potential Inhibitors for Malarial Aspartic Proteases, the Plasmepsins
Authors: Fäh Christoph , Mathys Roland , Hardegger Leo A. , Meyer Solange , Bur Daniel , Diederich François 
Published: July 2010

AbstractThe design and synthesis of novel fluorinated building blocks is of major interest in the development of new pharmaceuticals and agrochemicals. A quantitative search in the Protein Data Bank (PDB) manifests the use of di‐ and trifluoro hydrates for binding to hydrophilic enzyme active sites. Hydrated alicyclic α,α‐difluorinated ketones attract attention since they provide suitable functionalities for binding to the pair of catalytically active aspartate (Asp) side chains at the active site of aspartic proteases. This article expands the synthetic availability of this novel class of binding elements. Enantiomerically pure alicyclic α,α‐difluoro ketones are efficiently accessed by a straightforward route involving the separation of diastereoisomeric Mosher esters. The transformation into Mosher esters also enables the determination of the absolute configuration of the enantiomeric α,α‐difluoro ketones. The synthetic protocol was further expanded to the preparation of highly substituted cyclohexyl‐based α,α‐difluoro ketones bearing two exit vectors to fill the corresponding side pockets in the malarial aspartic proteases, the plasmepsins. Moderate biological activities toward these enzymes were determined, with IC50 (median inhibitory concentration) values in the lower micromolar range.