bluuebunny/crossref_metadata_2025_split huggingface dataset:
Experience of diet in patients with inflammatory bowel disease: A thematic synthesis of qualitative studies
Authors: Xiong Huan , Zhang Xu , Zeng Huiling , Xie Shanshan , Yi Shuanglian 
Published: April 2024

AbstractAimTo synthesise the dietary expesriences of patients with inflammatory bowel disease by reviewing relevant qualitative studies.BackgroundDiet plays a crucial role in the development and progression of inflammatory bowel disease (IBD). There is no specific diet that can be recommended for all patients. We conducted a synthesis of qualitative studies to gain a comprehensive understanding of the dietary management experience of patients with IBD, aiming to provide better dietary guidance in the future.DesignA qualitative synthesis was conducted following the Thomas and Harden method and reported following the ENTREQ statement.MethodsQualitative studies were systematically searched in five electronic databases: PubMed, PsycINFO, Embase, CINAHL, and Web of Science. There was no time limit for publication, and all database searches were up to 10 May, 2023. The Joanna Briggs Institute Qualitative Assessment and Review Instrument was utilised to appraise the quality of the included studies. Data for inclusion in articles were extracted and analysed using a thematic synthesis method.ResultsSix studies involving 119 patients were eventually included. The studies were conducted in six different countries. Four major themes were identified: the diet of patients with IBD is completely different from the normal one; manage symptoms and live with the disease by modifying diet; psychological adjustment to eating (be frustrated; worried and afraid; feel ashamed; growth and resilience); barriers and challenges (barriers from perceived social support; conflicts between diet and nutrition; challenges from food hedonism and cravings).ConclusionsPatients with IBD highlighted the distinction between their diet and the normal diet. Dietary modifications were used as a way to manage symptoms and live with the disease. In addition to physical symptoms, patients experienced diet‐related psychological changes. Dietary modifications in patients with IBD encounters difficulties and challenges, necessitating prompt guidance and intervention.(1) The implementation of dietary modifications in patients with IBD encounters numerous obstacles and complexities, necessitating prompt guidance and intervention.Patient or Public ContributionNo patient or public contribution.RegistrationThe protocol was registered with PROSPERO (CRD42023391545).
Exploration of decision aids to support advance care planning: A scoping review
Authors: Xu Ying , Han Ping‐ping , Su Xiao‐qin , Xue Ping , Guo Yu‐jie 
Published: April 2024

AbstractBackgroundAdvance care planning is a process through which people communicate their goals and preferences for future medical care. Due to the complexity of the decision‐making process, decision aids can assist individuals in balancing potential benefits and risks of treatment options.ObjectiveWhile decision aids have the potential to better promote advance care planning, their characteristics, content and application effectiveness are unclear and lack systematic review. Therefore, we aimed to explore these three aspects and establish a foundation for future research.DesignScoping review.MethodsThis scoping review adheres to the framework proposed by Arksey and O'Malley and the PRISMA‐ScR list. Six English‐language databases were systematically searched from the time of construction until 1 December 2023. Two researchers conducted the article screening and data extraction, and the extracted data was presented in written tables and narrative summaries.ResultsOf the 1479 titles and abstracts, 20 studies fulfilled the inclusion criteria. Types of decision aids were employed, mainly websites and videos. Decision aid's primary components center around 11 areas, such as furnishing information, exploring treatment and care preferences. The main manifestations were a significant increase in knowledge and improved recognition of patients' target value preferences. Among the aids, websites and videos for advance care planning have relatively high content acceptability and decision‐making process satisfaction, but their feasibility has yet to be tested.ConclusionsDecision aids were varied, with content focused on describing key information and exploring treatment and care preferences. Regarding application effects, the aids successfully facilitated the advance care planning process and improved the quality of participants' decisions. Overall, decision aids are efficient in improving the decision‐making process for implementing advance care planning in cancer and geriatric populations. In the future, personalised decision aids should be developed based on continuous optimization of tools' quality and promoted for clinical application.Reporting MethodThe paper has adhered to the EQUATOR guidelines and referenced the PRISMAg‐ScR checklist.No Patient or Public ContributionThis is a review without patient and public contribution.Registration: https://doi.org/10.17605/OSF.IO/YPHKF, Open Science DOI: 10.17605/OSF.IO/YPHKF.
Preoperative prediction of metastatic pheochromocytoma and paraganglioma using clinical, genetic, and biochemical markers: A cohort study
Authors: Park Seung Shin , Ahn Chang Ho , Lee Seunghoo , Lee Woochang , Kim Won Woong , Lee Yu‐Mi , Kim Su Jin , Sung Tae‐Yon , Lee Kyu Eun , Kim Jung Hee , Lee Seung Hun , Koh Jung‐Min 
Published: April 2024

AbstractBackgroundThe prevalence of metastatic pheochromocytoma and paraganglioma (PPGL) is approximately 15%–20%. Although there are indicators to assess metastatic risks, none of them predict metastasis reliably. Therefore, we aimed to develop and validate a scoring system using clinical, genetic, and biochemical risk factors to preoperatively predict the metastatic risk of PPGL.MethodsIn the cross‐sectional cohort (n = 180), clinical, genetic, and biochemical risk factors for metastasis were identified using multivariate logistic regression analysis, and a novel scoring system was developed. The scoring system was validated and compared with the age, size of tumor, extra‐adrenal location, and secretory type (ASES) score in the longitudinal cohort (n = 114).ResultsIn the cross‐sectional cohort, pseudohypoxia group‐related gene variants (SDHB, SDHD, or VHL), methoxytyramine >0.16 nmol/L, and tumor size >6.0 cm were independently associated with metastasis after multivariate logistic regression. Using them, the gene variant, methoxytyramine, and size of tumor (GMS) score were developed. In the longitudinal cohort, Harrell's concordance index of the GMS score (0.873, 95% confidence interval [CI]: 0.738–0.941) was higher than that of the ASES score (0.713, 95% CI: 0.567–0.814, p = 0.007). In the longitudinal cohort, a GMS score ≥2 was significantly associated with a higher risk of metastasis (hazard ratio = 25.07, 95% CI: 5.65–111.20). A GMS score ≥2 (p < 0.001), but not ASES score ≥2 (p = 0.090), was associated with shorter progression‐free survival.ConclusionThe GMS scoring system, which integrates gene variant, methoxytyramine level, and tumor size, provides a valuable preoperative approach to assess metastatic risk in PPGL.
Risk factors associated with symptoms of temporomandibular disorders among women with hypermobile Ehlers–Danlos syndrome: Questionnaire‐based study in Finland and Sweden
Authors: Yekkalam Negin , Novo Mehmed , Tyrberg Mårten J. , Sipilä Kirsi 
Published: April 2024

AbstractBackgroundGeneralized joint hypermobility as a characteristic feature of Ehlers–Danlos syndromes (EDS) is among the factors contributing to temporomandibular disorders (TMD).ObjectiveTo evaluate the prevalence of TMD symptoms and their risk factors among women born in Sweden or Finland who were 27‐ to 78‐year‐olds with diagnosed hypermobile EDS (hEDS).MethodsA cohort of women with confirmed hEDS (n = 185) was constructed from the members of the National EDS Associations in both countries. Based on questionnaire data, frequency of independent variables in terms of socio‐demographic, general health and oral health‐related factors, comorbid symptoms and psychological distress for self‐reported TMD symptoms as the dependent variables, were calculated first. Prevalence ratios (PR) and their 95% confidence interval (95% CI) were estimated for the association between independent and dependent variables.ResultsNearly all participants reported TMD symptoms (98%) with TMD pain (95%), TMJ clicking (90%) and jaw fatigue (80%) as the most common symptoms and TMJ crepitation (63%) and luxation (44%) as the least common symptoms. Risk factors for TMD among 27‐ to 50‐year‐olds participants were Finland as a country of birth, living alone and self‐reported worst pain in the body (not the joints). The respective risk factors among the 51‐ to 78‐year‐olds were Finland as a country of birth, family history of EDS, tinnitus and regularly taking contraceptives.ConclusionsAmong adult women with confirmed hEDS, socio‐demographic and health‐related factors and comorbid symptoms were significantly associated with TMD but with differences regarding age group. Therefore, management of TMD requires a multidisciplinary approach among the affected.
Visual psychosocial profiling of Chinese temporomandibular disorder pain patients and correlations with somatosensory function
Authors: Wang Yang , Zhao Yanping , Xie Qiufei 
Published: April 2024

AbstractBackgroundPsychosocial function of Chinese temporomandibular disorders (TMD) pain patients and the correlation with somatosensory function has not been sufficiently studied.ObjectiveThe study aims at assessing the psychosocial function of Chinese TMD pain patients by visualisation method and evaluating the correlations with somatosensory function quantitatively.MethodsThe Symptom Checklist 90 (SCL‐90) questionnaire and standardised quantitative sensory testing (QST) were administered to 70 Chinese TMD pain patients and age‐ and gender‐matched healthy controls (HCs). Of these, 40 TMD arthralgia patients received QST before and after medication. Psychosocial and somatosensory parameters were transformed into standardised scores. Differences within groups were assessed through t tests. Correlations between psychosocial and somatosensory profiles were explored through correlation analyses with Bonferroni correction for multiple comparisons.Results100% of the Chinese TMD pain patients exhibited psychosocial distress in contrast to HCs. Anger and hostility showed negative correlation with the thermal nonnociceptive parameter (thermal sensory limen, p =.002) and nociceptive parameters (cold pain threshold and pain pressure threshold, p<.001). Correlation analysis indicated that cold detection threshold was negatively correlated with somatization and mechanical pain sensitivity had a negative correlation with anger and hostility through medical treatment (p <.001).ConclusionsVisual psychosocial profiles provided an easy overview of psychosocial function in Chinese TMD pain patients. Anger and hostility was associated with increased thermal nonnociceptive and nociceptive sensitivity to stimuli. Psychosocial distress might be negatively associated with TMD treatment response which indicated a possible need for psychological intervention during treatment.
Basal differentiation and expression status of SOX2 and KLF4 in basal layers are prognostic factors for disease‐specific survival in oral squamous cell carcinoma
Authors: Murakami Kazuhiro , Kamiakito Tomoko , Kawata Hirotoshi , Kosami Koki , Nakaya Takeo , Noguchi Tadahide , Mori Yoshiyuki , Tanaka Akira 
Published: April 2024

AbstractBackgroundBasal differentiation in oral squamous cell carcinoma is usually detected at invasive sites. However, its significance as a prognostic value has been poorly investigated.MethodsCOL17 was selected as a basal differentiation marker because of its stable expression in the basal‐like cells of oral squamous cell carcinoma. Sixty‐five cases of oral squamous cell carcinoma were subclassified into COL17‐high (30 cases) and ‐low (35 cases) types, and the prognostic value was analyzed by Cox regression analysis. In addition, the stem cell markers such as SOX2, KLF4, MYC as well as the stem cell‐related markers BMI1, EZH2, and YAP and its paralog TAZ, were immunohistochemically analyzed. Their prognostic values were investigated along with their COL17 status by Cox regression analysis.ResultsNo significant difference was observed between the COL17‐high and ‐low groups in the disease‐specific survival and recurrence‐free survival in oral squamous cell carcinoma. When the COL17‐high and ‐low categories were combined with the SOX2, KLF4, EZH2, or YAP/TAZ status in the basal layers, together with gender and age as covariates, the hazard ratios reached 3.3, 3.7, 2.8, and 3.1, respectively. In addition, multivariate analysis, including COL17, SOX2, and KLF4, with gender and age as covariates, showed a significantly poor prognosis for disease‐specific survival.ConclusionBased on the relatively high hazard ratios, it is indicated that basal differentiation and the expression status of SOX2 and KLF4 in the basal layers are prognostic factors for oral squamous cell carcinoma.
Pubertal status and body image: An inquiry into experiences of adolescents in Ghana and Kenya
Authors: Mahama Sheriffa , Weichold Karina , Fehmer Nora , Mvungu Eunice N. , Natsuaki Misaki N. 
Published: April 2024

AbstractThe current study uses a mixed method design to investigate Kenyan and Ghanaian adolescents' experiences of puberty, and the relations between gender, country of origin, pubertal status, and body image appraisals (N = 86; Ghana = 46, Kenya = 40, 52.9% female aged 13 and 14). Qualitative results revealed seven major themes; puberty means a universal period of growth and transition into adulthood but also evokes negative emotions of shame, anxiety, and embarrassment, being in sync with peers during puberty is important and knowing that others in their lives similarly experience puberty is reassuring. Quantitative results revealed significant gender and country differences in pubertal status and body image. Ghanaian adolescents had more advanced pubertal status and more positive body image appraisals compared to Kenyan adolescents. Moderation analysis results revealed that for the Kenyan sample, post‐pubertal males had less favorable body image appraisals than their counterparts who were still pre pubertal whilst for females, post‐pubertal girls had more favorable body images than their counterparts. No such effects were observed with the Ghanaian sample. The findings highlight the need for context considerations in understanding body image during the pubertal transition to help identify relevant protective factors for possible interventions. The results affirm the importance of positive body image promotions for adolescents within the African context and suggest the need for much more comprehensive sex education with gender‐specific components to help allay fears about puberty, thus preventing the development of possible adaptation problems.
Taxing ride‐sharing: Which neighborhoods pay more?
Authors: Leccese Mario 
Published: April 2024

AbstractI examine the short‐run impact of taxing ride‐sharing trips on the price and usage of ride‐sharing across different neighborhoods of Chicago and investigate whether the tax had unequal effects on neighborhoods with different racial compositions. I document significant heterogeneity in price increases due to the tax across neighborhoods of departure, showing that this was correlated with their differential access to alternatives to ride‐sharing, such as public transit. Clustering neighborhoods based on their racial composition reveals that Black areas experienced particularly high price increases and reductions in usage. Overall, the burden of the tax fell more heavily on minority‐concentrated areas.
Ravulizumab facilitates reduced burden of vascular access, a major benefit in paediatric atypical haemolytic uraemic syndrome
Authors: Bleathman Freya , Kausman Joshua Y , Hosking Laine M , Forbes Thomas A 
Published: April 2024

BackgroundAtypical haemolytic uraemic syndrome (aHUS) is a rare thrombotic microangiopathy resulting from dysregulation of the alternative complement pathway, leading to multi‐organ dysfunction and chronic kidney disease. Eculizumab is an anti‐C5 monoclonal antibody therapy that has significantly improved aHUS disease control and patient outcomes, however it requires fortnightly intravenous dosing. This often necessitates long term central access and a high hospital attendance burden. Ravulizumab is a novel, next‐generation anti‐C5 monoclonal antibody engineered from eculizumab to reduce endosomal degradation of the antibody, increasing the dosing interval up to 8 weeks.Case SeriesIn this retrospective case series we present the transition of three children with aHUS from eculizumab to ravulizumab from a single tertiary paediatric nephrology service. All patients underwent genomic and immunological work up for aHUS, with no cause found. After stabilisation with eculizumab, two patients developed macrovascular thrombotic complications associated with indwelling central vascular catheters, ultimately leading to central access failure. All patients were transitioned from eculizumab to ravulizumab without relapse of aHUS. One patient successfully underwent deceased donor kidney transplantation with ravulizumab for complement inhibition. All patients have transitioned to peripheral access for infusions given the reduced frequency of dosing, maintaining good control of aHUS for 2–4 years.ConclusionRavulizumab permits sufficiently reduced frequency of infusion to allow for administration by peripheral cannulation – removing the risks of long term central vascular access often required to deliver eculizumab to paediatric patients.
Systematically assessing the quality of dental electronic health record data for an investigation into oral health care disparities
Authors: Kookal Krishna Kumar , Walji Muhammad F. , Brandon Ryan , Kivanc Ferit , Mertz Elizabeth , Kottek Aubri , Mullins Joanna , Liang Shuang , Jenson Larry E. , White Joel M. 
Published: April 2024

AbstractObjectivesThis work describes the process by which the quality of electronic health care data for a public health study was determined. The objectives were to adapt, develop, and implement data quality assessments (DQAs) based on the National Institutes of Health Pragmatic Trials Collaboratory (NIHPTC) data quality framework within the three domains of completeness, accuracy, and consistency, for an investigation into oral health care disparities of a preventive care program.MethodsElectronic health record data for eligible children in a dental accountable care organization of 30 offices, in Oregon, were extracted iteratively from January 1, 2014, through March 31, 2022. Baseline eligibility criteria included: children ages 0–18 with a baseline examination, Oregon home address, and either Medicaid or commercial dental benefits at least once between 2014 and 2108. Using the NIHPTC framework as a guide, DQAs were conducted throughout data element identification, extraction, staging, profiling, review, and documentation.ResultsThe data set included 91,487 subjects, 11 data tables comprising 75 data variables (columns), with a total of 6,861,525 data elements. Data completeness was 97.2%, the accuracy of EHR data elements in extracts was 100%, and consistency between offices was strong; 29 of 30 offices within 2 standard deviations of the mean (s = 94%).ConclusionsThe NIHPTC framework proved to be a useful approach, to identify, document, and characterize the dataset. The concepts of completeness, accuracy, and consistency were adapted by the multidisciplinary research team and the overall quality of the data are demonstrated to be of high quality.
A comparative study of old versus novel psychoactive substances on craving, perceived stigma and suicidal risk among rural‐dwelling patients with substance abuse
Authors: Eweida Rasha Salah , Abdelwahab Khedr Mahmoud , Hussein Rasha Mohamed 
Published: April 2024

Accessible SummaryWhat is known on the subject?

According to recent estimates, 10.4% of adults are patients with substance abuse, which is almost double the global rate.

Rural areas are typically marginalized, compounded by a lack of access to mental health care, creating a startling disparity in suffering from drug use issues among rural cohorts.

What the paper adds to existing knowledge?

Drawing on data from a descriptive comparative design would provide a distinctive picture related to the similarities and/or differences in relation to craving and how it affects perceived stigma and suicidal risk among patients using old versus novel psychoactive substances.

What are the implications for practice?

Substance abuse is a leading public health concern that forces nurses to encompass it into their agendas to tackle this looming problem.

Addiction rehabilitation services are frequently run by nurses. They are well‐versed in supporting patients during their journey to recovery and enabling them to adjust to a new lifestyle.

AbstractIntroductionSubstance use disorder is a leading public health concern that currently, nations regulatory agencies are grappled with. The noticeable difference in the chemical structures between old and novel psychoactive substances can result in significant clinical complications among patients with substance abuse.AimThe study aims to compare substance craving, perceived stigma and suicidal risk among patients addicted to old and novel psychoactive substances (NPS).MethodA descriptive comparative design was adopted on a sample of 105 patients with substance use who completed The Penn Alcohol Craving Scale (PACS), The Perceived Stigma of Addiction Scale (PSAS) and Suicide Probability Scale (SPS).DiscussionMost participants were male, with 89.5% in the old addictive substance group and 93.8% in the new addictive substance group. A statistically significant difference in the NPS groups' perceptions of stigma (23.4 ± 5.3) compared to the old addictive substance group (20.6 ± 4.2), (t = 3.037, p = .003).Implication for PracticeParticipants in the new substance group report more suicidal ideation, negative self‐evaluation and hostility than those in the old substance group. Policies and practices should be tailored to the type of drug used and potential risk factors to avoid suicide among patients with substance abuse.