bluuebunny/crossref_metadata_2025_split huggingface dataset:
Vascular dysfunction occurs prior to the onset of amyloid pathology and Aβ plaque deposits colocalize with endothelial cells in the hippocampus of female APPswe/PSEN1dE9 mice
Authors: Waigi Emily W. , Pernomian Laena , Crockett Alexia M. , Costa Tiago J. , Townsend Paul , Webb R. Clinton , McQuail Joseph A. , McCarthy Cameron G. , Hollis Fiona , Wenceslau Camilla F. 
Published: June 2024

AbstractIncreasing evidence shows that cardiovascular diseases (CVDs) are associated with an increased risk of cognitive impairment and Alzheimer’s diseases (AD). It is unknown whether systemic vascular dysfunction occurs prior to the development of AD, if this occurs in a sex-dependent manner, and whether endothelial cells play a role in the deposition of amyloid beta (Aβ) peptides. We hypothesized that vascular dysfunction occurs prior to the onset of amyloid pathology, thus escalating its progression. Furthermore, endothelial cells from female mice will present with an exacerbated formation of Aβ peptides due to an exacerbated pressure pulsatility. To test this hypothesis, we used a double transgenic mouse model of early-onset AD (APPswe/PSEN1dE9). We evaluated hippocampus-dependent recognition memory and the cardiovascular function by echocardiography and direct measurements of blood pressure through carotid artery catheterization. Vascular function was evaluated in resistance arteries, morphometric parameters in the aortas, and immunofluorescence in the hippocampus and aortas. We observed that endothelial dysfunction occurred prior to the onset of amyloid pathology irrespective of sex. However, during the onset of amyloid pathology, only female APP/PS1 mice had vascular stiffness in the aorta. There was elevated Aβ deposition which colocalized with endothelial cells in the hippocampus from female APP/PS1 mice. Overall, these data showed that vascular abnormalities may be an early marker, and potential mediator of AD, but exacerbated aortic stiffness and pressure pulsatility after the onset of amyloid pathology may be associated with a greater burden of Aβ formation in hippocampal endothelial cells from female but not male APP/PS1 mice.
Graphical Abstract
Evaluating compliance with the care standard of proactively assessing bone health in patients with diabetes: a pilot audit of practice across Asia by the Asia Pacific Consortium on Osteoporosis (APCO)
Authors: Chandran M. , Aftab N. , Amin A. , Amphansap T. , Bhadada S. K. , Chadha M. , Chan D. C. , Hew F. L. , Kaur S. , Khan A. H. , Kwee A. K. , Ho-Pham L. T. , Lekamwasam S. , Minh D. C. , Prasanth A. , Sharma R. , Valleenukul T. , Zehra N. , Mithal A. 
Published: June 2024

Abstract
Summary
This pilot audit explored how bone health is assessed patients with diabetes in diverse centres across Asia. Only 343 of 1092 (31%) audited patients had a bone health assessment, 27% of whom were diagnosed with osteoporosis. Quality improvement strategies are needed to address gaps in patient care in this area.

Purpose
The Asia Pacific Consortium on Osteoporosis (APCO) Framework outlines clinical standards for assessing and managing osteoporosis. A pilot audit evaluated adherence to clinical standard 4, which states that bone health should be assessed in patients with conditions associated with bone loss and/or increased fracture risk; this report summarises the audit findings in patients with diabetes. A secondary aim was to assess the practicality and real-world use of the APCO bone health audit tool kit.

Methods
Eight centres across Asia participated in the pilot audit, selecting diabetes as the target group. Participants reviewed their practice records for at least 20 consecutively treated patients with the target condition. Questions covered routine investigations, bone health assessment, osteoporosis diagnosis, and patient referral pathways. Data were summarised descriptively.

Results
The participants represented public hospitals, university medical centres, and private clinics from India, Malaysia, Pakistan, Singapore, Taiwan, and Vietnam that see an estimated total of 95,000 patients with diabetes per year. Overall, only 343 of 1092 audited patients (31%) had a bone health assessment. Osteoporosis was subsequently diagnosed in 92 of 343 (27%) patients.

Conclusion
Bone health was not assessed in most patients with diabetes. The results provide insight into current practices across diverse Asian centres and demonstrate the practical value of the audit tool kit. Participant feedback has been used to improve the tool kit. Results of this pilot audit are being used in the respective centres to inform quality improvement projects needed to overcome the gap in patient care.
Residual Stress Analysis of Re-autofrettage of a Swage-Autofrettaged Tube by Computer Modeling Incorporating Accurate Material Representation
Authors: Hu Zhong , Parker Anthony P. 
Published: June 2024

AbstractAutofrettage processes allow engineers to reduce the thickness of thick-walled cylinders or components in high-pressure applications without sacrificing strength, life, or safety. However, during the autofrettage process, residual stresses will be generated due to plastic deformation. The complex tube material behavior is dominated by the Bauschinger effect. A better understanding and accurate prediction of the residual stress field is critical, which will enable better piping design strategies to minimize deformation and stresses under operating conditions. This study aims to predict and analyze residual stresses resulting from hydraulic re-autofrettage of a swage-autofrettaged thick-walled cylinder by computer modeling. A case study was performed on a thick-walled cylinder of A723 alloy with a radial interference of 2.5%. In order to investigate the effect of the chosen material constitutive representation, results based on the true material constitutive model were compared with the simplified prevalent material model of bi-linear kinematic strain hardening. Computer implementation for the true material was via a user-developed subroutine that incorporates the complex Bauschinger effect. The results indicate that an accurate material constitutive representation is crucial for better and more accurate prediction and understanding of residual stresses induced by autofrettage processes. Computer modeling based on the true material constitutive representation will likely prove to be a powerful tool for the design of autofrettage processes in general and thick-walled cylinders in particular.
Development of vitamin K analysis method using column switching high-performance liquid chromatography method and analysis results of various food items for vitamin K content
Authors: Tanaka Rina , Tanaka Ryusuke 
Published: June 2024

AbstractIn this study, we developed a column-switching high-performance liquid chromatography (HPLC) method with fluorescence detection for the analysis of vitamin K. Column-switching is accomplished by changing the direction of flow using a switching valve with a set time program. Using this method, three vitamin K, phylloquinone (PK), menaquinone-4 (MK-4), and menaquinone-7 (MK-7), were separated and identified with high sensitivity, and impurities were eliminated. This method was used to determine the vitamin K content in meat, fish meat, snails, bivalves, sea urchins, seaweeds, vegetables, tea, soy products, milk products, and supplements. The results showed that chicken showed the highest content of MK-4 (15.35 ± 0.35 μg/100 g), matcha showed the highest content of PK (3069.66±80.10 μg/100 g), and dried natto showed the highest content of MK-7 (3997.57±79.42 μg/100 g). This method can also be used to analyze vitamin K in supplements and pharmaceuticals. The results of this study revealed that different manufacturers add different types of vitamin K to their commercial supplements and infant formulas. The developed method provides highly reproducible and quantitative results and allows for the rapid analysis of the three vitamin K types. Thus, the method developed in this study may aid the sequential analysis of vitamin K in different samples to assess food nutrients.
On linear algebra of r-Hankel and r-Toeplitz matrices with geometric sequence
Authors: Shi Baijuan , Kızılateş Can 
Published: June 2024

AbstractMatrix theory plays a crucial role in solving practical problems and performing computational operations. In particular, specific types of matrices and their linear algebraic properties are of paramount significance for these processes. In this paper, we study the properties of r-Hankel and r-Toeplitz matrices whose entries are geometric sequences, and then the determinants, inverse matrix, generalized inverse matrix (the Moore-Penrose inverse), and spectral norms of such matrices are obtained.
Hepatitis E Virus RNA Detection in Liver and Muscle Tissues Sampled from Home Slaughtered Domestic Pigs in Central Italy
Authors: Ferri Gianluigi , Giantomassi Giorgia , Tognetti Daniele , Olivastri Alberto , Vergara Alberto 
Published: June 2024

AbstractHepatitis E virus is a worldwide emerging foodborne pathogen; raw or undercooked meats and liver pork products can cause infection through the orofecal route. In Central-Southern Italy, small traditional farming method, associated with the possibility of environmental sharing with wild species, can facilitate HEV diffusion and persistence. The aim of this study was to determine HEV genotype and subtype in Marche region from home slaughtered domestic pigs involved in small and traditional food chains. A total of 236 liver and muscle tissues and 6 pooled salami samples were screened. Laboratory workflow started with homogenization, followed by RNA extraction. Nested reverse transcription PCR and qRT-PCR were used to amplify specific parts of overlapping open reading frames belonging to the HEV genome. A total of 42/236 (17.79%) liver and 8/236 (3.39%) diaphragm specimens were positive; none of the pooled salami specimens showed positive HEV signal. The discovered HEV3c presented high nucleotide similarities with ones amplified from wild boar populations hunted in the same province. Extensive farming methods and environmental sharing with wild animal species support cross-infection infections, as observed in the present study. Although salami resulted negative for HEV RNA detection, the effects of food technologies on viral loads remain unclear. Therefore, further scientific investigations coupled with efficacious standardized laboratory procedures will be the next challenge.
Trust in Public and Private Providers of Health Apps and Usage Intentions
Authors: Binzer Björn , Kendziorra Jennifer , Witte Anne-Katrin , Winkler Till J. 
Published: June 2024

AbstractMobile health apps, particularly personal health records (PHRs), play a vital role in healthcare digitalization. However, the varying governance approaches for providing PHR platforms have led to a growing debate on the adequate regulation of health technology with regard to their adoption. This article investigates how provider governance, whether public or private, influences users’ intentions to use and decisions to download a PHR app. Drawing on institutional trust, privacy calculus, and privacy control frameworks, the study develops hypotheses about how provider governance affects the pathways through which trust influences users’ intentions to adopt the app. Data acquired from an online experiment in the German market reveals that users exhibit a higher level of trust in public providers compared to the same app provided by private companies. Furthermore, provider governance significantly alters the paths in how trust influences usage intentions through perceived benefits, perceived risks, and privacy control. These findings contribute to the development of a sectoral theory of privacy calculus and privacy control in Information Systems (IS). Moreover, they offer practical insights for healthcare regulators and health app providers with the aim of promoting the acceptance and usage of PHRs and other mobile health apps.
Chemotherapy resistance in acute myeloid leukemia is associated with decreased anti-tumor immune response through MHC molecule and B7 family members
Authors: Ge Jing , Yin Xiaoxuan , Sun Xin , Kou Liduo , Xue Xin , Ma Juan 
Published: June 2024

AbstractAcute myeloid leukemia (AML) remains challenging due to chemotherapeutic drug-resistance (CDR). Aberrant expression B7 family proteins are involved in tumors evasion. We wonder whether B7 family protein alteration in AML CDR further supports tumor escape. Here, we establish AML cytarabine-resistant cell line U937/Ara-C and report on the expression MHC molecule and B7 family member. HLA-ABC was highly expressed similarly on both cell lines. MIC (MHC class I chain related) A/B and B7-H6 was moderately expressed on the surface of U937 and decreased dramatically by U937/Ara-C. In contrast, enhanced expression of B7-H1 and B7-H7 by U937/Ara-C was observed. HLA-DR and other B7 family members including CD80, CD86, B7-DC, B7-H2, B7-H3, B7-H4, and B7-H5 were not detected by both cell lines. Compared co-cultured with U937, peripheral blood mononuclear cells showed a decreased cytotoxicity when incubated with U937/Ara-C, as indicated by decreased levels of granzyme B and perforin production, accompanied with less TNF-α and lactate dehydrogenase secretion. In conclusion, AML CDR further evades the anti-tumor immune response which may through MHC molecule and B7 family members.
Systemische Sklerose
Authors: Kickinger David 
Published: June 2024

ZusammenfassungBei der systemischen Sklerose (SSc) handelt es sich um eine komplexe, chronische Autoimmunerkrankung, die sowohl zu einer Fibrose der Haut als auch der inneren Organe führen kann. Die Prognose hinsichtlich des Verlaufs ist dabei sehr variabel und unter anderem abhängig von der Organbeteiligung. Die medikamentöse Therapie konnte unter anderem durch den Einsatz neuer Substanzen erweitert werden und dadurch kann beispielsweise die interstitielle Lungenbeteiligung, die mit einer erhöhten Mortalität einhergeht, besser behandelt werden. Dennoch stellt die SSc weiterhin eine Erkrankung mit einer hohen Mortalität und Morbidität dar und es sind zukünftige Studien für eine weitere Verbesserung der medikamentösen Therapie notwendig.
Sex Working Parents: Surveilled in the Parenting Panopticon
Authors: Fuentes Kimberly , Coleman Sophia , Ye Kim , Lee Katherine , Madness Ashley 
Published: June 2024

Abstract
Introduction
Research suggests that many sex workers are parents. This paper furthers the literature’s understanding of everyday barriers plaguing sex working parents (SWP) that compound to complicate their ability to build connections with their child’s world and other sex workers.

Methods
This Participatory Action Research study employed five focus groups in 2022 with thirteen English-speaking SWP in Los Angeles. The focus groups utilized group discussion in tandem with an art-based exercise to explore the value of sex work to parenting and where SWP require support.

Results
SWP reported benefits of engaging in sex work in terms of strengthening their relationships with their children and a concurrent constant fear that they could lose their parental rights if they were outed. This study applies Foucault’s theoretical conceptualization of a discipline society (operating through the ever-present potential of punishment and surveillance, including by private actors) to the participant’s lived experiences and self-conceptualization.

Conclusions
The paper explores the value of a sex worker–driven critique of stigma discourse for a more targeted description of the apprehension SWP experience.

Policy Implications
SWP are positioned at the intersection of various forms of surveillance, criminalization, and stigma. Recommendations highlight a need for building interdependence and representation with SWP to combat carceral surveillance practices.
Microfluidics-on-a-chip for designing celecoxib-based amorphous solid dispersions: when the process shapes the product
Authors: Figueiredo Joana , Mendes Maria , Pais Alberto , Sousa João , Vitorino Carla 
Published: June 2024

AbstractThe fundamental idea underlying the use of amorphous solid dispersions (ASDs) is to make the most of the solubility advantage of the amorphous form of a drug. However, the drug stability becomes compromised due to the higher free energy and disorder of molecular packing in the amorphous phase, leading to crystallization. Polymers are used as a matrix to form a stable homogeneous amorphous system to overcome the stability concern. The present work aims to design ASD-based formulations under the umbrella of quality by design principles for improving oral drug bioavailability, using celecoxib (CXB) as a model drug. ASDs were prepared from selected polymers and tested both individually and in combinations, using various manufacturing techniques: high-shear homogenization, high-pressure homogenization, microfluidics-on-a-chip, and spray drying. The resulting dispersions were further optimized, resorting to a 32 full-factorial design, considering the drug:polymers ratio and the total solid content as variables. The formulated products were evaluated regarding analytical centrifugation and the influence of the different polymers on the intrinsic dissolution rate of the CXB-ASDs. Microfluidics-on-a-chip led to the amorphous status of the formulation. The in vitro evaluation demonstrated a remarkable 26-fold enhancement in the intrinsic dissolution rate, and the translation of this formulation into tablets as the final dosage form is consistent with the observed performance enhancement. These findings are supported by ex vivo assays, which exhibited a two-fold increase in permeability compared to pure CXB. This study tackles the bioavailability hurdles encountered with diverse active compounds, offering insights into the development of more effective drug delivery platforms.
Graphical Abstract
The impact of Learning from Country on teachers’ understandings of place and community: insights from the Culturally Nourishing Schooling project
Authors: Coombs David , Langdon Shanna , Jabir Zana , Burgess Cathie , Amazan Rose 
Published: June 2024

Abstract
In this paper, we present findings from the Culturally Nourishing Schooling (CNS) project data, collected during and after a series of experiential and immersive Learning from Country (LFC) activities with teachers working in New South Wales (NSW) schools in Australia. LFC is positioned as the critical first step in the CNS whole-school reform project, which seeks to improve Aboriginal and Torres Strait Islander students’ educational experiences and outcomes by developing teacher capacity to deliver culturally responsive curriculum and pedagogies. By centring Country and community, LFC, along with four other CNS strategies, encourages teachers to think, act and relate differently with respect to First Nations students, families, communities and the places and histories in which they are grounded. Drawing on Burgess et al.’s LFC framework, we found evidence of teachers: professing an ethical commitment to respecting and honouring local Aboriginal knowledges and knowledge holders; understanding the importance of connectedness and relational practices in their teaching; reflecting critically on their pre-existing ideas about Aboriginal students and communities and developing ‘place-consciousness’ or ‘Country consciousness’. We conclude that the LFC strategy is influencing the ways that teachers conceptualise and enact education in relation to Country and community, with the potential to deliver significant benefits to First Nations students, families and communities.
Salvia officinalis leaf extract-stabilized NiO NPs, ZnO NPs, and NiO@ZnO nanocomposite: Green hydrothermal synthesis, characterization and supercapacitor application
Authors: Zenkin Kübra , Durmuş Sefa , Emre Deniz , Bilici Ali , Yılmaz Selehattin 
Published: June 2024

AbstractIn this study, NiO nanoparticles (NiO NPs) and NiO@ZnO nanocomposite were synthesized for the first time using a Salvia officinalis (S. officinalis) extract-assisted hydrothermal process. The S. officinalis leaf extract served as a natural reducing and capping agent. The synthesized NiO NPs, ZnO NPs, and NiO@ZnO nanocomposite were thoroughly characterized using various techniques, including Fourier-transform infrared spectroscopy (FT-IR), ultraviolet–visible spectroscopy (UV–Vis), powder X-ray diffraction (PXRD), scanning electron microscopy (SEM), transmission electron microscopy (TEM), energy-dispersive X-ray spectroscopy (EDX), energy-dispersive spectrometry (EDS) mapping, vibrating sample magnetometer (VSM), and cyclic voltammetry (CV) analysis. The direct and indirect band gap energies of NiO NPs, ZnO NPs, and NiO@ZnO were found to be 3.00, 2.28, and 2.71 eV, and 2.63, 1.91, and 2.23 eV, respectively. The crystallite sizes were analyzed using PXRD spectra through Scherrer and Williamson–Hall (W–H) methods. TEM analysis revealed that the average particle sizes of NiO NPs, ZnO NPs, and NiO@ZnO were 16.0, 207.5, and 31.0 nm, respectively. The magnetic properties of all nanomaterials were assessed via the VSM technique. Specific capacitance (Cs) values, determined from CV voltammograms, were 196.8, 632.4, and 785 Fg-1 at a scan rate of 25 mVs-1 for NiO NPs, ZnO NPs, and NiO@ZnO, respectively. These findings suggest that the green-synthesized NiO@ZnO nanocomposite holds significant potential as a high-performance electrode material for supercapacitor applications.
Clinical and diagnostic characteristics of Hashimoto’s encephalopathy: a single-center, retrospective study
Authors: Lee Jung-Ju , Park Soo-Min , Park Kyung-Il , Kang Kyusik , Lee Woong Woo , Kim Byung Kun , Kim Yong Soo , Yoo Ilhan 
Published: June 2024

Abstract
Background and purpose
Diagnosing Hashimoto’s encephalopathy (HE) is challenging. In contrast to other types of autoimmune encephalitis, HE shows an excellent response to steroid treatment. We aimed to investigate the rates of antithyroid antibodies (ATAs) and probable HE in patients with unexplained mental dysfunction and compare the clinical characteristics between the good- and poor-outcome groups.

Methods
We retrospectively reviewed the medical records and electroencephalography (EEG) and neuroimaging findings of patients admitted to the Department of Neurology of our hospital from March 1, 2006, to February 28, 2023. Using our proposed diagnostic criteria for probable HE, we compared the clinical characteristics between the good- and poor-outcome groups. We also investigated the rates of ATA positivity and probable HE.

Results
In total, 198 patients exhibited altered mentation, rapidly progressive cognitive decline, or myoclonus. ATA tests were performed on 86 patients, and the detection rates of ATAs and probable HE were 29.1% and 25.6%, respectively. Of the 22 patients enrolled, the good- and poor-outcome groups comprised 19 and 3 patients, respectively. Clinical seizures occurred in seven patients. Nonconvulsive status epilepticus on EEG was observed in six patients, all of whom were intractable to antiepileptic drugs. Nineteen of 21 patients (90.5%) treated with immunosuppressants showed good outcomes.

Conclusions
HE is a rare clinical disorder, but not as rare as previously thought. When HE is suspected, steroids should be considered the first-line treatment. Early diagnosis and adequate treatment are critical to achieve good outcomes in HE.