bluuebunny/crossref_metadata_2025_split huggingface dataset:
Enantioselective Aza‐Morita–Baylis–Hillman Reaction Using Aliphatic α‐Amidosulfones as Imine Surrogates
Authors: Abermil Nacim , Masson Géraldine , Zhu Jieping 
Published: February 2010

AbstractThe bifunctional catalyst 6′‐deoxy‐6′‐acylamino‐β‐isocupreidine (1) served both as a base to trigger the in situ generation of N‐sulfonylimine from readily available α‐amidosulfones and as a chiral nucleophile to initiate the enantioselective aza‐Morita–Baylis–Hillman (aza‐MBH) reaction. α‐Methylene‐β‐amino‐β‐alkyl carbonyl compounds, difficultly accessible previously, can now be synthesized in excellent yields and enantioselectivities.
Prevalence of asthma by industry and occupation in the U.S. working population
Authors: McHugh Michelle K. , Symanski Elaine , Pompeii Lisa A. , Delclos George L. 
Published: February 2010

AbstractBackgroundWorkers are potentially exposed to asthmagens daily. Our study was conducted to estimate the prevalence of asthma among working adults in the U.S. by industry and occupation.MethodsUsing data from the National Health and Nutrition Examination Survey (2001–2004), multiple logistic regression was used to investigate associations between industry and occupation and current asthma as defined by positive responses to “Has a doctor or other health professional ever told you that you have asthma?” and “Do you still have asthma?”ResultsWorkers in mining (17.0%), health‐related industries (12.5%), teaching (13.1%), or in health‐related occupations (12.6%) had the highest prevalence of asthma. As compared to construction industry workers, workers in mining (aOR = 5.2, 95% CI: 1.1–24.2) or health‐related (aOR = 2.3, 95% CI: 1.1–4.8) industries had significantly higher odds of asthma.ConclusionOur study adds to the increasing evidence that miners, healthcare workers and teachers remain high‐risk working populations and appropriate evaluation and control measures are needed to protect these workers. Am. J. Ind. Med. 53:463–475, 2010. © 2010 Wiley‐Liss, Inc.
Mutations at KCNQ1 and an unknown locus cause long QT syndrome in a large Australian family: Implications for genetic testing
Authors: Summers Kim M. , Bokil Nilesh J. , Lu Foong Teng , Low Jiun Tsuen , Baisden John M. , Duffy David , Radford Dorothy J. 
Published: February 2010

AbstractA large Australian family affected with long QT syndrome (LQTS) was studied. The medical characteristics of the 16 clinically affected members were consistent with LQT1. A previously identified mutation in KCNQ1 was found in 12 affected individuals and 1 unaffected infant but absent in 4 affected family members. A haplotype consisting of specific alleles for microsatellites flanking in KCNQ1 was associated with the mutation. This was absent from the four affected individuals without the mutation, who had three different haplotypes in this region, indicating that LQTS is unlikely to be segregating with KCNQ1 in these anomalous family members. A genome scan revealed 12 regions where all four of these individuals shared alleles. One region on chromosome 21 contained the KCNE1, KCNE2, KCNJ6, and KCNJ15 genes. A common variant of KCNE1 was segregating in the family but did not explain the anomalous cases. A candidate region on chromosome 7 contained the AKAP9 and KCND2 genes. A previously reported mutation in the N‐terminal Yotiao region of AKAP9 was absent from the family. No evidence was found implicating any other known or suspected LQTS gene. This family shows that there remain unidentified genetic causes of LQTS which are clinically significant and highlights the difficulties associated with genetic testing in LQTS, since we cannot rule out risk in individuals who are negative for the known mutation in KCNQ1 without knowing the second disease locus. © 2010 Wiley‐Liss, Inc.
Electrical properties and transport conduction mechanism of nitrile rubber/poly(vinyl chloride) blend
Authors: Mansour S. A. , Al‐Ghoury M. E. , Shalaan E. , El Eraki M. H. I. , Abdel‐Bary E. M. 
Published: February 2010

AbstractThe current–voltage characteristics of acrylonitrile butadiene rubber (NBR)/poly(vinyl chloride) (PVC) blends are studied as a function of sample temperature and PVC content. These samples showed ohmic behavior up to (225 V), after this value the behavior become SCLC (space charge limited conduction). The results obtained show that the charge carriers are generated by Richardson–Schottky emission from the electrode as well as from trapped ionic impurities at high fields. The activation energy of the prepared samples was calculated by using Arrhenius equation. © 2010 Wiley Periodicals, Inc. J Appl Polym Sci, 2010
Preparation of regular micropitted polylactide films via phase separation and their cell affinity evaluation
Authors: Tian Ye , Wang Yingjun , Zhou Changren , Zeng Qinhui 
Published: February 2010

AbstractThe microscale topography of biomaterial surfaces has a great effect on the adhesion and proliferation behavior of cells. In this study, polylactide (PLA) films with regular micropitted surfaces were prepared by a phase‐separation technique. The effect of the surface topography on the wettability and cell affinity was investigated with contact angle measurements and osteoblast incubation, respectively. The results showed that the shape of the pits could be controlled by changes in the film‐forming parameters, including the PLA solution concentration, nonsolvent content, temperature, and solvent volatilization speed. These patterned films had significantly enhanced hydrophobicity because of the existence of micropits on the surface, and their hydrophobicity increased with the pit size increasing. Osteoblast spreading was improved on the patterned surface, and so was cell adhesion. However, the proliferation of cells on micropitted surfaces showed no distinction from the proliferation on smooth surfaces, and this indicated that the pit pattern had a great effect on the spreading and adhesion of cells but little on the proliferation of cells. © 2010 Wiley Periodicals, Inc. J Appl Polym Sci, 2010
Stipa tenacessima L cationized fibers as adsorbent of anionic dyes
Authors: Ghali Amel El , Baouab Mohamed Hassen V , Roudesli Mohamed Sadok 
Published: February 2010

AbstractThe extraction of Stipa tenacessima L Alfa fibers was performed using alkaline procedure to remove noncellulosic substances such as pectin, lignin, and hemicellulose. The degree of polymerization of extracted and purified Alfa fibers was determined using viscosimetric method and extracted fibers were used as a cationic ion‐exchange material by treating alkali‐cellulose of Alfa with EpoxyPropylTriMethylAmmonium Chloride (EPTMAC). Evidence of grafting was monitored using IR spectroscopy and thermogravimetry analysis. Two EPTMAC‐Alfa fibers with different %N were prepared and tested as adsorbent of four acid dyes: Acid Blue 25 (AB 25), Acid Yellow 99 (AY 99), Reactive Yellow 23 (RY 23), and Acid Blue 74 (AB 74). The modeling of the adsorption isotherms using Langmuir, Freundlich, and Jossens allowed the determination of isotherm constants leading to characterize the different adsorbent/adsorbate systems prepared. Thermodynamic parameters such as change in free energy (ΔG), the enthalpy (ΔH), and the entropy (ΔS) were also evaluated. Additionally, regeneration of adsorbent solid supports by desorption process in fixed bed column was reported. © 2010 Wiley Periodicals, Inc. J Appl Polym Sci, 2010
Preparation and properties of hybrid cement‐in‐polymer coatings used for the improvement of fiber‐matrix adhesion in textile reinforced concrete
Authors: Weichold Oliver 
Published: February 2010

AbstractReactive cement‐in‐polymer dispersions have been prepared from poly(vinyl alcohol), poly(ethylene‐co‐vinyl acetate), and poly(vinyl acetate) and a nonhydrated, fine‐grained cement, and used to coat multifilament glass‐rovings. The influence of the molecular properties of the polymer, such as the chemical composition and molecular weight as well as the cement content in the dispersion, on the reinforcing performance of the coated rovings in concrete has been studied using scanning electron microscopy and tensile tests. All coated rovings significantly surpass the uncoated glass in terms of mechanical behavior. The best bonding was obtained with hydrophobic, PVAc‐based coatings, since the slow hydrolysis and swelling of this polymer controls cement hydration and the formation of the interphase. The mechanical behavior of the coated rovings is barely influenced by the molecular weight of the polymer, but decreases with decreasing cement content. © 2010 Wiley Periodicals, Inc. J Appl Polym Sci, 2010
Trace element status of activated charcoals and carbon black: Influence on thermal stability of modified lyocell solutions
Authors: Wendler Frank , Lepri Fabio G. , Borges Daniel L. G. , Araujo Rennan G. O. , Welz Bernhard , Meister Frank 
Published: February 2010

AbstractThe influence of surface‐active additives on the thermal stability of cellulose/N‐methylmorpholine‐N‐oxide monohydrate solutions were investigated. The application of a dynamic mixing tool incorporating the additive directly before the forming module enhances the thermal stability. Thermal stabilization by means of a polymeric stabilizer system and adjusting the pH value by sodium hydroxide increased the storage life‐time for the additive suspension as revealed by calorimetric isoperibolic step measurements. Further investigations concerned the analysis of the trace element status of the additives. Analytical results for 16 elements have been obtained by inductively coupled plasma optical emission spectrometry (ICP OES) after microwave‐assisted acidic digestion, and seven elements, Cr, Cu, Fe, Mn, Mo, Ni, and V have been determined using direct solid sampling high‐resolution continuum source graphite furnace AAS (SS‐HR‐CS GF AAS) as a reference method. Partial least squares regression between measured and calculated temperatures for beginning exothermicity (Ton) has been used to investigate the prediction capability of the investigated techniques. Whereas the ICP OES measurement gives only an acceptable correlation employing all 16 metals plus Fe(II), results obtained by SS‐HR‐CS GF AAS exhibit a correlation coefficient of 0.99. © 2010 Wiley Periodicals, Inc. J Appl Polym Sci, 2010
Isothermal crystallization kinetics of anhydrous sodium acetate nucleated poly(ethylene terephthalate)
Authors: Deshpande V. D. , Jape Sandeep 
Published: February 2010

AbstractStudies on the isothermal crystallization kinetics of poly(ethylene terephthalate) (PET) nucleated with anhydrous sodium acetate were carried out. The nucleated agent had succeeded in promoting greater rates of crystallization in PET. A study of the melting behavior of the samples revealed that the nucleating agents promoted formation of thinner lamellae. The equilibrium melting temperature (T) of samples was determined using linear and nonlinear Hoffman Weeks procedure. The nonlinear Hoffman Week's procedure was found to be inapplicable in the current study. The Lauritzen‐Hoffman secondary nucleation theory was applied to determine the nucleation parameter (Kg), fold surface energy (σe), and work of chain folding (q). σe and q decreased on addition of nucleating agent. The approximate and exact form of the Lauritzen Z‐test was used to determine the operating regime. The operating regime was found to be primarily regime II for the range of temperatures studied. © 2010 Wiley Periodicals, Inc. J Appl Polym Sci, 2010
Synthesis and characterization of new soluble polyamides from an unsymmetrical diamine bearing a bulky triaryl pyridine pendent group
Authors: Ghaemy Mousa , Nasab Syeyd Mojtaba Amini , Alizadeh Raouf 
Published: February 2010

AbstractNew unsymmetrical diamine monomer containing triaryl pyridine pendent group, 2,4‐diaminophenyl [4‐(2, 6‐diphenyl‐4‐pyridyl) phenyl]ether, was synthesized via aromatic substitution reaction of 1‐chloro‐2,4‐dinitrobenzene with 4‐(2,6‐diphenyl‐4‐pyridyl) phenol, followed by Pd/C‐catalyzed hydrazine reduction. Five Polyamides (PA) were prepared by the phosphorylation polycondensation of different dicarboxylic diacids with the diamine. Inherent viscosities of PAs were in the range 0.51–0.59 g/dL indicating formation of medium molecular weight polymers. The weight and number average molecular weights of a PA, (PA‐d), determined by GPC were 6944 g/mol and 17,369 g/mol, respectively. PAs exhibited glass‐transition temperatures (Tg) in the range 140–235°C. These polymers, essentially amorphous, were soluble in polar aprotic solvents such as DMF, NMP, DMAc, DMSO, pyridine, m‐cresol, and THF. The initial decomposition temperatures (Ti) of PAs, determined by TGA in air, were in the range 300–380°C indicating their good thermal stability. © 2010 Wiley Periodicals, Inc. J Appl Polym Sci, 2010
Epstein‐Barr virus promotes interferon‐α production by plasmacytoid dendritic cells
Authors: Quan Timothy E. , Roman Robert M. , Rudenga Benjamin J. , Holers V. Michael , Craft Joseph E. 
Published: February 2010

AbstractObjectiveEpstein‐Barr virus (EBV) infection has been linked to systemic lupus erythematosus (SLE), as demonstrated by the presence of increased seroprevalence and elevated viral loads, but the mechanism of this linkage has not been elucidated. Increased interferon‐α (IFNα) levels and signatures, which are associated with innate immune responses, have been found in patients with SLE. Plasmacytoid dendritic cells (PDCs) are innate immune cells that mediate viral immunity by producing large quantities of IFNα, but the role they play during infection with EBV remains unclear. To address this issue, we investigated the ability of EBV to promote IFNα production by PDCs in healthy subjects.MethodsHuman PDCs were sorted and cultured in the presence of EBV, EBV‐encoded RNA, and EBV double‐stranded DNA. IFNα production by PDCs was measured by enzyme‐linked immunosorbent assay, with the activation of these cells measured by flow cytometry.ResultsWe found that EBV DNA and RNA promoted IFNα production by human PDCs through engagement of Toll‐like receptor 9 (TLR‐9) and TLR‐7, respectively, with the initial viral recognition by PDCs mediated by binding to class II major histocompatibility complex (MHC) molecules.ConclusionThese data demonstrate that class II MHC–specific engagement by virus, with subsequent viral nucleic acid recognition, mediates IFNα production by PDCs. Our results suggest that elevated levels of IFNα found in SLE patients may be a result of aberrantly controlled chronic viral infection.
Endothelial injury and repair in systemic vasculitis of the young
Authors: Clarke L. A. , Hong Y. , Eleftheriou D. , Shah V. , Arrigoni F. , Klein N. J. , Brogan P. A. 
Published: February 2010

AbstractObjectiveEndothelial injury is central to the pathogenesis of vasculitis. The purpose of this study was to assess how indices of endothelial injury and repair change during different stages of disease activity in children with primary systemic vasculitis (PSV).MethodsFifty children with PSV, 17 children with nonvasculitic inflammatory diseases (pediatric inflammatory disease controls), 35 healthy age‐ and sex‐matched pediatric controls, and 27 healthy adult controls were included in the study. Biomarkers examined were endothelial microparticles (EMPs), circulating endothelial cells (CECs), angiogenic growth factors, and endothelial progenitor cells (EPCs). EMP binding to annexin V, EMPs expressing CD144 or E‐selectin, and EPCs expressing vascular endothelial growth factor receptor 2 (VEGFR‐2), CD133, and CD34 were examined by flow cytometry. CECs were enumerated using immunomagnetic bead extraction techniques, and VEGF and angiopoietin 2 (Ang‐2) were measured by enzyme‐linked immunosorbent assay.ResultsLevels of CD144+ EMPs, CECs, VEGF, and EPCs were all significantly elevated in children with active vasculitis as compared with healthy children, and the levels declined with remission‐inducing therapy in the individual patients. Treatment‐naive patients with active disease had significantly higher levels of VEGF and Ang‐2 than did those with active disease who were receiving treatment, although the levels of CECs and EMPs remained high in both of these groups.ConclusionElevation of the levels of CECs, EMPS, EPCs, VEGF, and Ang‐2 occurs during active vasculitis in children. EPC responses to active vasculitis are different in children as compared with that observed in adults with vasculitis, and both CECs and EMPs can be used to monitor disease activity in children with vasculitis.
The adoption of university library Web site resources: A multigroup analysis
Authors: Kim Yong‐Mi 
Published: February 2010

AbstractUniversity libraries invest a massive amount of resources in digitizing information for the Web, yet there is growing concern that much of this information is being underutilized. The present study uses the technology acceptance model (TAM) to investigate university library website resources (ULWR) usage. We categorize users based on academic roles and then analyze them as subgroups in order to observe different adoption patterns across groups. A total of 299 usable responses was collected from four different universities and across three populations: undergraduate, master, and doctoral student/faculty groups. The findings show that different library users indeed access ULWR for different reasons, resulting in a need for tailored managerial efforts. Overall, the extended TAM explains undergraduate students' usage best; the explanatory power of the model is significantly lower for the doctoral student/faculty group. Some of the findings challenge results reported in TAM research in other fields. The unexpected findings may result from the application of the model to a different context. Detailed theoretical implications and managerial guidance are offered.
Verkapselung von Apfelwickler‐Granuloseviren für eine nachhaltige biotechnische Schädlingsbekämpfung
Authors: Pemsel M. , Roßmann M. , Schatz R. , Schlücker E. , Freitag D. , Schwab S. , Scheurer A. 
Published: February 2010

AbstractDer PGSS (Particles from Gas Saturated Solutions)‐Hochdrucksprühprozess nutzt die Löslichkeit von überkritischen Fluiden in Schmelzen und wird für die Herstellung von Partikeln und feinen Pulvern im Mikrometermaßstab verwendet. Er wird außerdem zur Verkapselung von aktiven Substanzen eingesetzt. Das Verfahren wurde weiterentwickelt, um den Anforderungen von biologisch aktiven Materialien bezüglich Temperaturempfindlichkeit und Umweltverträglichkeit gerecht zu werden. Das hier verwendete biologisch aktive Material ist das Cydia pomonella Granulosevirus (Fam. Baculoviridae, CpGV), das weltweit im kommerziellen Apfelbau zur Bekämpfung des Apfelwicklers (Cydia pomonella L., Lep.: Tortricidae) eingesetzt wird. Das CpGV besitzt aufgrund absoluter Selektivität und hoher Effektivität gegenüber dem Zielorganismus sowohl ökologische als auch ökonomische Vorteile. Die Nachteile des unbehandelten CpGV wie starke UV‐Lichtempfindlichkeit, die mehrere Anwendungen im Feld notwendig macht, und eine geringe Aufnahmerate, können durch die Verkapselung in eine organische Matrix vermieden werden. Die Wirksamkeit der verkapselten CpGV‐Formulierung wurde schon erfolgreich in Labortests nachgewiesen. Das Pflanzenschutzmittel (PSM) wird momentan batchweise hergestellt. Die Aufgabe besteht nun darin den Prozess wirtschaftlich auf eine flexible kontinuierlich arbeitende Anlage zu übertragen, um den Anforderungen des Marktes nachzukommen.
Model‐based prediction of defective DNA mismatch repair using clinicopathological variables in sporadic colon cancer patients
Authors: Sinicrope Frank , Foster Nathan R. , Sargent Daniel J. , Thibodeau Stephen N. , Smyrk Thomas C. , O'Connell Michael J. 
Published: February 2010

AbstractBACKGROUND:Colon cancers with defective DNA mismatch repair (MMR) have a favorable prognosis and may lack benefit from 5‐fluorouracil–based adjuvant chemotherapy. The authors developed models to predict MMR deficiency in sporadic colon cancer patients using routine clinical and pathological data.METHODS:TNM stage II and III colon carcinomas (n = 982) from 6 5‐fluorouracil–based adjuvant therapy trials were analyzed for microsatellite instability and/or MMR protein expression. Tumor‐infiltrating lymphocytes (TILs) were quantified (n = 326). Logistic regression and a recursive partitioning and amalgamation analysis were used to identify predictive factors for MMR status.RESULTS:Defective MMR was detected in 147 (15%) cancers. Tumor site and histologic grade were the most important predictors of MMR status. Distal tumors had a low likelihood of defective MMR (3%; 13 of 468); proximal tumors had a greater likelihood (26%; 130 of 506). By using tumor site, grade, and sex, the logistic regression model showed excellent discrimination (c statistic = 0.81). Proximal site, female sex, and poor differentiation showed a positive predictive value (PPV) of 51% for defective MMR. In a patient subset (n = 326), a model including proximal site, TILs (>2/high‐power field), and female sex showed even better discrimination (c statistic = 0.86), with a PPV of 81%.CONCLUSIONS:Defective MMR is rare in distal, sporadic colon cancers, which should generally not undergo MMR testing. Proximal site, poor differentiation, and female sex detect 51% of tumors with defective MMR; substituting TILs for grade increases the PPV to 81%. These data can increase the efficiency of MMR testing to assist in clinical decisions. Cancer 2010. © 2010 American Cancer Society.
Intra‐arterial versus intravenous chemoradiation for advanced head and neck cancer: Results of a randomized phase 3 trial
Authors: Rasch Coen R. N. , Hauptmann Michael , Schornagel Jan , Wijers Oda , Buter Jan , Gregor Theo , Wiggenraad Ruud , de Boer Jan Paul , Ackerstaff Annemiek H. , Kroger Robert , Hoebers Frank J. P. , Balm Alfons J. M. 
Published: February 2010

AbstractBACKGROUND:Chemoradiation is the preferred treatment for advanced stage IV head and neck cancer. Higher doses of chemotherapy yielded promising results in vitro and vivo, confirmed by intra‐arterial (IA) cisplatin‐based chemoradiation in phase 2 studies.METHODS:Two hundred and thirty‐nine patients with (functionally) unresectable head and neck cancer were included, from 2000 to 2004, in a multicenter, randomized phase 3 trial, comparing IA and intravenous chemoradiation. Intravenous chemoradiation comprised 3×100 mg/m2 cisplatin infusion on Days 1, 22, 43 combined with 70 Gy in 35 daily fractions. The IA chemoradiation treatment arm comprised 4x150 mg/m2 cisplatin administered in the tumor‐feeding artery on Days 1, 8, 15, 22, immediately followed by systemic rescue with sodium thiosulfate with the same radiotherapeutic regimen.RESULTS:Two patients were excluded from analysis because of nontreatment‐related death immediately after randomization (n = 1) and esophageal carcinoma (n = 1). The median follow‐up was 33 months 1‐104 months. Ninety percent of the patients required tube feeding during treatment. Renal toxicity >grade 2 was 9% in the intravenous compared with 1% in the IA treatment arm (P ≤ .0001). There was no difference in locoregional control, disease‐free survival (DFS) or overall survival (OS), between the treatment arms. At 3 years, local control, locoregional control, DFS, and OS was .76, .63, .44, .51 in the IA versus .70, .65, .47, .47 in the intravenous treatment arm, respectively.CONCLUSIONS:Cisplatin‐based IA chemoradiation was not superior to intravenous chemoradiation for advanced stage IV head and neck cancer regarding locoregional control and survival. Cancer 2010. © 2010 American Cancer Society.
FNA diagnosis of teratoma lung: A case report
Authors: Siddiqui Farhan Asif , Jain Anshu , Maheshwari Veena , Beg Mohammed Haneef 
Published: February 2010

AbstractA case of teratoma occurring in the lung of a 27‐year‐old female, diagnosed by fine‐needle aspiration cytology and confirmed by histopathology, is being presented here. Occurrence of teratoma at this site is a rare entity. The authors take this opportunity to report such a rare case, and as to the best of our knowledge, not many cases have been reported in literature till date. Diagn. Cytopathol. 2010;38:758–760. © 2010 Wiley‐Liss, Inc.