bluuebunny/crossref_metadata_2025_split huggingface dataset:
Extranodal extension influences prognosis in pancreatic body/tail cancer: A retrospective cohort study
Authors: Sung Min Kyu , Chun Jihyun , Park Yejong , Kwak Bong Jun , Lee Woohyung , Song Ki Byung , Lee Jae Hoon , Kim Song Cheol , Hong Seung Mo , Hwang Dae Wook 
Published: June 2024

AbstractBackground/PurposeExtranodal extension (ENE) is an established prognostic factor in various malignancies, affecting survival in pancreatic head cancer (PHC). However, its significance in pancreatic body/tail cancer (PBTC) remains unclear. Therefore, we aimed to investigate the impact of ENE on PTBC prognosis.MethodsWe analyzed data collected from electronic medical records of patients with PBTC who underwent distal pancreatectomy at a single center between January 2011 and December 2015. The patients were categorized based on ENE presence and prognostic implications were evaluated using Kaplan–Meier survival curves and Cox proportional hazards model.ResultsPBTC cases involving lymph node (LN) metastasis and ENE exhibited significantly lower disease‐free (DFS) and overall survival (OS) rates compared to cases without LN metastasis or ENE (median DFS; N0, 23 months; LN+/ENE−, 10 months; LN+/ENE+, 5 months; p < .001). No statistically significant difference was observed in DFS and OS rates between patients with N1/N2 in the group without ENE and those with ENE+. Multivariate analysis confirmed ENE as a significant adverse prognostic factor.ConclusionsENE significantly predicts poor prognosis in PBTC, particularly in cases with nodal metastasis. The current cancer staging system for PBTC should incorporate ENE status. Moreover, different staging systems should be considered for PHC and PBTC.
Body Satisfaction, Exercise Dependence, and White Matter Microstructure in Young Adults
Authors: Xie Hongsheng , Zhang Feifei , Gan Sanshan , Wu Jiahao , Wu Baolin , Qin Kun , Wang Song , Sweeney John A. , Gong Qiyong , Jia Zhiyun 
Published: June 2024

BackgroundSelf‐body satisfaction is considered a psychological factor for exercise dependence (EXD). However, the potential neuropsychological mechanisms underlying this association remain unclear.PurposeTo investigate the role of white matter microstructure in the association between body satisfaction and EXD.Study TypeProspective.PopulationOne hundred eight regular exercisers (age 22.11 ± 2.62 years; 58 female).Field Strength/Sequence3.0 Tesla; diffusion‐weighted echo planar imaging with 30 directions.AssessmentThe Body Shape Satisfaction (BSS) and Exercise Dependence Scale (EDS); whole‐brain tract‐based spatial statistics (TBSS) and correlational tractography analyses; average fractional anisotropy (FA) and quantitative anisotropy (QA) values of obtained tracts.Statistical TestsThe whole‐brain regression model, mediation analysis, and simple slope analysis. P values <0.05 were defined as statistically significant.ResultsThe BSS and EDS scores were 37.33 ± 6.32 and 68.22 ± 13.88, respectively. TBSS showed negative correlations between EDS and FA values in the bilateral corticospinal tract (CST, r = −0.41), right cingulum (r = −0.41), and left superior thalamic radiation (STR, r = −0.50). Correlational tractography showed negative associations between EDS and QA values of the left inferior frontal occipital fasciculus (r = −0.35), STR (r = −0.42), CST (r = −0.31), and right cingulum (r = −0.28). The FA values, rather than QA values, mediated the BSS‐EDS association (indirect effects = 0.30). The BSS was significantly associated with the EDS score at both low (β = 1.02) and high (β = 0.43) levels of FA value, while the association was significant only at the high level of QA value (β = 1.26).Data ConclusionEXD was correlated with white matter in frontal‐subcortical and sensorimotor networks, and these tracts mediated the body satisfaction‐EXD association. White matter microstructure could be a promising neural signature for understanding the underlying neuropsychological mechanisms of EXD.Level of Evidence2Technical EfficacyStage 1
Timing patterns of initial respiratory syncytial virus infection and factors influencing disease severity in hospitalized infants with different health status
Authors: Shi Peiru , Wang Rong , Liu Enmei , Deng Yu 
Published: June 2024

AbstractThis study aimed to determine the timing patterns of the initial respiratory syncytial virus (RSV) infection and to identify the factors influencing disease severity in infants of varying health status. A retrospective study was conducted at the Affiliated Children's Hospital of Chongqing Medical University from 2012 to 2022. The timing of the first RSV infection was estimated in infants with differing health status using correlation analysis, considering their birth time. Logistic regression was utilized to identify factors influencing severe RSV infection in these infants. RSV detection primarily occurred in the winter and spring. Epidemic season and peak timing of RSV were not significantly affected by health status or the COVID‐19 pandemic. A strong positive correlation was observed between the age at RSV infection and the interval from birth to the RSV peak season. Infants born during the RSV epidemic season exhibited a higher likelihood of infection within the first 2 months postbirth. In contrast, those born outside the RSV epidemic season were more susceptible to infection during the subsequent peak. Notably, infants with pre‐existing health conditions contracted RSV at an earlier age compared to their healthy counterparts. Among healthy infants, severe RSV infection was associated with sex, age, and timing of infection. For infants with underlying conditions, severe RSV infection was primarily related to age and timing of infection. The initial timing of RSV infection in infants varied depending on their health status. Young age and infection timing during the RSV epidemic season were significant risk factors for severe RSV infection. These findings provide a theoretical basis for optimizing immunization strategies for infants with diverse health conditions.
Development of a human papillomavirus (HPV) multiplex immunoassay to profile HPV antibodies
Authors: Quang Chau , Chung Amy W. , Kemp Troy J. , Ratu Tupou , Tuivaga Evelyn , Russell Fiona M. , Licciardi Paul V. , Toh Zheng Q. 
Published: June 2024

AbstractNeutralizing antibodies (NAbs) are considered the primary mechanism of vaccine‐mediated protection against human papillomaviruses (HPV), the causative agent of cervical cancer. However, the minimum level of NAb needed for protection is currently unknown. The HPV pseudovirion‐based neutralization assay (PBNA) is the gold standard method for assessing HPV antibody responses but is time‐consuming and labor‐intensive. With the development of higher valency HPV vaccines, alternative serological assays with the capacity for multiplexing would improve efficiency and output. Here we describe a multiplex bead‐based immunoassay to characterize the antibody responses to the seven oncogenic HPV types (HPV16/18/31/33/45/52/58) contained in the current licensed nonavalent HPV vaccine. This assay can measure antibody isotypes and subclasses (total IgG, IgM, IgA1–2, IgG1–4), and can be adapted to measure other antibody features (e.g., Fc receptors) that contribute to vaccine immunity. When tested with serum samples from unvaccinated and vaccinated individuals, we found high concordance between HPV‐specific IgG using this multiplex assay and NAbs measured with PBNA. Overall, this assay is high‐throughput, sample‐sparing, and time‐saving, providing an alternative to existing assays for the measurement and characterization of HPV antibody responses.
Creativity and Perception: Unveiling the Role of Cross‐Modal Audiovisual Integration
Authors: Xiao Xinyao , Wang Jian , Shu Yanyan , Tan Junying 
Published: June 2024

ABSTRACTMultisensory environments rich in modal integration provide cues from various sensory modalities including visually, auditorily, and tactilely. Such modal integration plays a crucial role in cognitive processing, specifically in fostering creativity. Numerous studies highlight that emotional coherence through cross‐modal affective integration enhances cognitive competencies such as memory, attention, and the capacity to generate original, fluent ideas. Nonetheless, current research lacks comparative studies pinpointing how different sensory modalities impact individual creativity. We addressed this research void by employing a cross‐model matching paradigm, anchored on the concept of emotional coherence. Our investigation evaluated the impact of varying emotional stimuli (both positive and negative) on creativity performance, considering single sensory modalities (visual and auditory), as well as their cross. Our study participants were 119 Chinese university students who completed a creative task under varying emotional stimulation modality conditions. We observed that the bimodal audiovisual integration of positive emotional stimuli most effectively enhanced creativity as compared to solely auditory modality. The visual modality seemed the least effective, underscoring the impact of multichannel integration. Interestingly, the bimodal audiovisual integration of negative emotional stimuli significantly boosted originality, albeit with little difference in fluency relative to the auditory modality. Based on the theoretical significance of multimodal emotional integration, our interpretation of these findings suggests that audiovisual cross‐modal emotional integration, with its rich emotional information, serves as a catalyst for enhancing originality. However, we observed that the facilitative effect on overall creativity and fluency is primarily observed in the context of positive emotions. It is important to note that we carefully controlled for participants' creative personality factors and conducted three types of emotional evaluations across modalities to ensure the validity of our results. Furthermore, the impact of cross‐modal audiovisual emotional integration on creativity, both in terms of originality and fluency, is influenced by the distinct emotional perceptual characteristics inherent to each modality.
The interfacial properties of biosurfactant mixtures
Authors: McMillan Janet R. , Miller Daniel S. , Nimako‐Boateng Caroline , Wilson Lauren , Kuo Tzu‐Chi , Tesoldi Micol Frederica , Young Timothy , Izmitli Aslin 
Published: June 2024

AbstractThere is growing global demand to transition to more sustainable surfactant technologies. Towards this vision, bio‐based surfactants and biosurfactants are being explored as alternatives to traditional petrochemical surfactants. However, the transition towards these technologies is expected to be gradual, therefore there is a critical need to formulate new biosurfactants in combination with traditional surfactant classes such as alkoxylates, sulfates and amine‐oxides to achieve a balance of performance, cost, and sustainability. To this end, we report a study of the impact of sophorolipid biosurfactants on the cloud point of alcohol ethoxylates, and on the surface tension and foaming of alkyl sulfate/amine‐oxide mixtures. We make the surprising finding that high‐acid sophorolipids can act as highly efficient hydrotropes and increase the cloud point of alcohol ethoxylates. In sulfate/amine‐oxide mixtures, models of experimental data suggest that both high‐acid and high‐lactone sophorolipids can replace 40–50% of the primary surfactants without significant changes to the surface tension or foaming performance. These findings will enable the next‐generation of high performing sustainable cleaning formulations to be realized.
N‐Carbamylglutamate in ovo feeding improves carcass yield, muscle fiber development, and meat quality in broiler chickens
Authors: Yuan‐hao Wang , Ayalew Habtamu , Wang Jing , Wu Shugeng , Qiu Kai , Qi Guanghai , Zhang Haijun 
Published: June 2024

AbstractBACKGROUNDInsufficient endogenous nutrients in the broiler embryo can lead to muscle gluconeogenesis, which ultimately affects the post‐hatching performance of chicks. This study investigated the effects of in ovo feeding (IOF) of N‐carbamylglutamate (NCG) on the growth hormones, carcass yield, and meat quality in broilers. Fertile eggs from a 30‐week‐old Ross 308 breeder flock were divided into three treatment groups: NC (non‐injection), SC (100 μL saline‐injection), and NCG (2 mg NCG injection). Each group had six replicates, with 70 eggs per replicate during incubation. Injections were administered on the 17.5th day of embryonic development. After hatching, 270 chicks were selected for 42‐day rearing for further sampling.RESULTSChicks in the NCG group had significantly higher body weight (BW) and average daily gain (ADG) at the growing phase, increased growth and testosterone hormone in both feeding phases (21 and 42 days), and improved average daily gain (ADG) and food conversion ratio (FCR) in both grower and entire feeding phases (P < 0.05). Triiodothyronine (T3) and tetraiodothyronine (T4) levels, carcass yield, dressing, drum weight, breast muscle weight, drumstick weights, thighs, pectoralis major, and their part percentage of carcass were improved in the NCG group (P < 0.05), these effects were varied along feeding phases. Moreover, IOF of the NCG also improved pectoralis breast muscle color values at 24 h post mortem (P < 0.05).CONCLUSIONThese results suggest that NCG injection at the late embryonic age of broiler enhances growth performance and meat quality throughout the lifespan and this can probably be attributed to an increase in thyroid and testosterone hormones, indicating potential involvement in metabolic and nutrient partitioning pathway regulation. © 2024 Society of Chemical Industry.
Magneto‐Acoustic Theranostic Approach: Integration of Magnetomotive Ultrasound Shear Wave Elastography and Magnetic Hyperthermia
Authors: Pi Zhaoke , Deng Dingqian , Chen Xin , Chen Siping , Lin Haoming , Chen Mian 
Published: June 2024

ObjectivesAlthough magnetically induced hyperthermia has shown great efficiency in the treatment of solid tumors, it is still a challenge to avoid incomplete ablation or overtreatment. In this study, we applied magnetomotive ultrasound shear wave elastography (MMUS‐SWE) as a tool for real‐time image guidance and feedback in the magnetic hyperthermia (MH) process. We called this new method as magneto‐acoustic theranostic approach (MATA).MethodsIn MATA, a ferromagnetic particle (fMP) was simultaneously used as a thermoseed for MH and a shear wave source for MMUS‐SWE. The fMP was excited by a high‐frequency magnetic field to induce the heating effect for MH. Meanwhile, the fMP was stimulated by a pulsed magnetic field to generate shear wave propagation for MMUS‐SWE. Thus, the changes in elastic modulus surrounding fMP can be used to estimate the therapy effect of MH.ResultsThe phantom and in vitro experiments were conducted to verify the feasibility of MATA, which has good performance in magnetothermal conversion and treatment efficacy feedback. The shear wave speed of the isolated pork liver changed significantly after the MH process, which varied from about 1.36 to 4.85 m/s.ConclusionsPreliminary results proved that changes in elastic modulus could be useful to estimate the therapy effect of MH. We expect that MATA, which is the integration of MMUS‐SWE and MH, will be a novel theranostic method for clinical translation.
An insight into racial bias in dermoscopy repositories: A HAM10000 data set analysis
Authors: Morales‐Forero Andres , Rueda Jaime Lili , Gil‐Quiñones Sebastian Ramiro , Barrera Montañez Marlon Y. , Bassetto Samuel , Coatanea Eric 
Published: June 2024

AbstractBackgroundStudies have revealed a lack of representation of skin of colour patients in academic sources of dermatologic diseases, including databases. This visual racism has consequently generated less comfort and confidence among the specialists in the care and attention of this ethnic group, including the opportunity of being correctly diagnosed.ObjectivesTo investigate and uncover potential racial biases in the HAM10000 data set through an exploratory analysis of the dark skin tones representation, the identification of inaccuracies in its documentation, the recognition of relevant skin conditions absent for darker skin and the lack of ethnic diversity variables crucial for validating diagnosis across different skin tones.MethodsAn exploratory examination was conducted to investigate the occurrence of dark skin within the HAM10000 database (housed in a Harvard Dataverse repository), consisting of 10,015 dermoscopic images of skin lesions. A visual depiction encompassing the whole skin tones was generated by sampling four crucial data points from each image and applying the Gray World Algorithm for colour normalization. To confirm the accuracy of the graphical representation, dermatologists validated the pixel sampling process by analysing a randomly selected 10% of the images for each type of skin lesion. This visual representation was produced for the entire data set as well as for each skin lesion type. The study was further enhanced by comparing the skin lesion representation within the HAM10000 data set against documented prevalences of relevant conditions affecting dark skin.ResultsLess than 5% of the images came from dark‐skinned patients. Nevertheless, in about 4.9% of cases, our pixel sampling method might inadvertently capture shadows or dark spots resulting from the imaging device or the lesion itself rather than the individual's actual skin tone. In addition, there are inaccuracies in the data set's claims of diversity and comprehensive coverage, notably the underrepresentation of conditions prevalent in darker skin and the absence of ethnic diversity variables.ConclusionsVisual racism is an issue that needs to be addressed in medical sources of information and education. Image databases and artificial intelligence models need to be nourished with information, including all skin types, to guarantee equal access to opportunities. Furthermore, any instances where conditions affecting people of colour are underrepresented must be meticulously documented and reported to highlight and address these disparities effectively. This is particularly important in dermoscopy imaging, where solely relying on image‐based racial bias analysis is limited. The alteration of the patient's actual skin tone by the dermatoscope's lighting complicates the accurate assessment of racial bias.
Outcomes of Concurrent Balloon Eustachian Tuboplasty and Tympanostomy Tube Placement in Children
Authors: Ahluwalia Jatin , Babu Seilesh , Haupert Michael , Thottam Prasad 
Published: June 2024

ObjectivesBalloon dilation eustachian tuboplasty (BDET) has been proven to be a safe treatment option for children with eustachian tube dysfunction (ETD). This study aims to analyze the long‐term outcomes of children who underwent concurrent BDET and tympanostomy tube (TT) placement. We hypothesize that patients who underwent simultaneous therapy have experienced a low overall rate of middle ear pathology and have consistent hearing quality at subsequent office visits.MethodsRetrospective chart review of 19 pediatric patients (36 ears) who previously underwent concurrent BDET and TT placement. Patient charts within the extended postoperative period were reviewed. Specific data points included need for reoperation, rates of middle ear pathology, audiological outcomes, and number of previous TT placements.ResultsPediatric patients who underwent concurrent BDET and TT placement had long‐term success in 34/36 ears (94.4%). All postoperative tympanograms and audiograms (100%) were normal when performed within 12 months after the procedure. Notably, 34/36 ears (94.4%) had history of tube placement in the past. Patients had an average of three sets of tympanostomy tubes prior to undergoing concurrent BDET and TT.ConclusionConcurrent BDET and TT placement may be an effective treatment option for pediatric patients with persistent eustachian tube dysfunction. Specifically, BDET may be a useful adjunct tool in pediatric patients with refractory ETD despite having multiple sets of tympanostomy tubes. This study aims to strengthen the argument of performing multimodal therapy in pediatric patients with recurrent middle ear disease.Level of Evidence4 Laryngoscope, 134:4799–4802, 2024
Facile Fabrication of Starch‐Based UV Barrier Films with Remolding Ability and Reinforcement for Water Resistance
Authors: Shibasaki Kazuki , Hsu Yu‐I , Uyama Hiroshi 
Published: June 2024

AbstractPetroleum‐derived plastics are harmful to ecosystems because they are not decomposed in the natural environment. Therefore, the replacement of petroleum‐derived plastics with biodegradable plastics has attracted considerable attention. UV‐barrier films in the agricultural and packaging fields are mainly composed of petroleum‐derived plastics, which have a negative impact on the ecosystem when they leak into the environment. Thermoplastic starch (TPS) is an inexpensive and sustainable biodegradable plastic that has recently attracted considerable attention. In this study, the addition of UV barrier properties and remolding ability to TPS for replacing petroleum‐derived UV barrier films are investigated. Also, a biodegradable polyester coating is studied to improve the water resistance of the prepared UV‐barrier TPS (U‐TPS). To prepare U‐TPS, a conjugated enamine structure is formed by reacting starch acetoacetate with diamine monomers during melt kneading. U‐TPS exhibits high UV barrier properties across the UV regions (200–400 nm) owing to the presence of acetoacetyl groups and enamines. These results indicate the possibility of increasing the utilization of TPS in agriculture and as a packaging material.
Consumer perceptions of influencer gifting
Authors: Marchand André , Holler Andrea , Dünschede Theresa 
Published: June 2024

AbstractMany social media influencers promote products they receive from brands, which send those items without any explicit obligations but with the objective of being endorsed voluntarily. With increasing frequency, brands send their products together with additional gifts that influencers can, but do not have to, display either. For example, a branded perfume might be complemented by additional gifts of flowers, champagne, and macarons. Through such elaborate influencer gifting, brands hope to elicit more favorable reactions from both influencers and consumers. However, elaborate influencer gifting also raises concerns about consumer perceptions. With four experiments, this research shows that influencer gifting is superior to paid influencer marketing in terms of influencer trustworthiness and brand attitude outcomes, which can be explained by the increased effort signaled in the business relationship between the brand and the influencer. However, elaborate gifting also can prompt stronger perceptions of a persuasive attempt by the brand, which can lead to decreased trust in influencers who display the elaborate gifts voluntarily. The negative effect linked to perceptions of a persuasive attempt can be mitigated if the elaborate gift is justified by a brand occasion, such as the brand's anniversary.