bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prospective and Retrospective Measures of Child Maltreatment and Their Association With Psychopathology
Authors: Baldwin Jessie R. , Coleman Oonagh , Francis Emma R. , Danese Andrea 
Published: May 2024

ImportanceProspective and retrospective measures of childhood maltreatment identify largely different groups of individuals. However, it is unclear if these measures are differentially associated with psychopathology.ObjectiveTo analyze the associations of prospective and retrospective measures of childhood maltreatment with psychopathology.Data SourcesBased on a preregistered protocol, Embase, PsycInfo, and MEDLINE were searched for peer-reviewed studies published by January 1, 2023, that measured the associations of prospective and retrospective measures of child maltreatment with psychopathology.Study SelectionTitles and abstracts of all articles captured by the search and full texts of potentially eligible studies were independently screened by 2 authors. Observational studies with measures of the association of prospective and retrospective measures of childhood maltreatment with psychopathology were included.Data Extraction and SynthesisMultiple investigators independently extracted data. Multilevel random-effects meta-analyses were used to pool the results and test predictors of heterogeneity.Main Outcome and MeasuresAssociations between prospective or retrospective measures of child maltreatment and psychopathology, both unadjusted and adjusted (ie, the association between prospective measures of maltreatment and psychopathology adjusted for retrospective measures, and vice versa), and moderation of these associations by preselected variables.ResultsThe meta-analyses were based on 24 studies including 15 485 individuals (51.0% female; mean age, 21.3 years at retrospective report). Retrospective measures of childhood maltreatment showed stronger associations with psychopathology relative to prospective measures in both unadjusted analyses (retrospective measures: odds ratio [OR], 2.21; 95%, 1.94-2.42 vs prospective measures: OR, 1.56; 95% CI, 1.39-1.76) and adjusted analyses (retrospective measures: OR, 2.14; 95% CI, 1.90-2.42 vs prospective measures: OR, 1.27; 95% CI, 1.13-1.41). There was no statistically significant moderation of the unadjusted or adjusted associations between prospective measures of child maltreatment and psychopathology. The associations between retrospective measures and psychopathology were stronger when the assessment of psychopathology was based on self-reports and was focused on internalizing or emotional disorders.Conclusions and RelevancePsychopathology is more strongly associated with retrospective measures—which capture the first-person, subjective appraisal of childhood events reflected in memory recall—compared to prospective measures—which essentially capture third-person accounts of such events. Maltreatment-related psychopathology may be driven by subjective interpretations of experiences, distressing memories, and associated schemas, which could be targeted by cognitive interventions.
Management of Gallstone Pancreatitis
Authors: McDermott James , Kao Lillian S. , Keeley Jessica A. , Nahmias Jeffry , de Virgilio Christian 
Published: May 2024

ImportanceGallstone pancreatitis (GSP) is the leading cause of acute pancreatitis, accounting for approximately 50% of cases. Without appropriate and timely treatment, patients are at increased risk of disease progression and recurrence. While there is increasing consensus among guidelines for the management of mild GSP, adherence to these guidelines remains poor. In addition, there is minimal evidence to guide clinicians in the treatment of moderately severe and severe pancreatitis.ObservationsThe management of GSP continues to evolve and is dependent on severity of acute pancreatitis and concomitant biliary diagnoses. Across the spectrum of severity, there is evidence that goal-directed, moderate fluid resuscitation decreases the risk of fluid overload and mortality compared with aggressive resuscitation. Patients with isolated, mild GSP should undergo same-admission cholecystectomy; early cholecystectomy within 48 hours of admission has been supported by several randomized clinical trials. Cholecystectomy should be delayed for patients with severe disease; for severe and moderately severe disease, the optimal timing remains unclear. Preoperative endoscopic retrograde cholangiopancreatography (ERCP) is only useful for patients with suspected cholangitis or biliary obstruction, although the concomitance of these conditions in patients with GSP is rare. Modality of evaluation of the common bile duct to rule out concomitant choledocholithiasis varies and should be tailored to level of concern based on objective measures, such as laboratory results and imaging findings. Among these modalities, intraoperative cholangiography is associated with reduced length of stay and decreased use of ERCP. However, the benefit of routine intraoperative cholangiography remains in question.Conclusions and RelevanceTreatment of GSP is dependent on disease severity, which can be difficult to assess. A comprehensive review of clinically relevant evidence and recommendations on GSP severity grading, fluid resuscitation, timing of cholecystectomy, need for ERCP, and evaluation and management of persistent choledocholithiasis can help guide clinicians in diagnosis and management.
Design and Preparation of Multicolor Long‐Lifetime Fluorescent Material Based on Charge‐Separated States
Authors: Lu Peng , Zhou Mengdie , Yuan Yongjie , Yu Yan , Zhang Hailiang 
Published: May 2024

AbstractAfterglow materials have the advantages of long luminescent lifetime and large stokes shift, which show good application prospects in fields such as probes, anti‐counterfeiting, and organic light‐emitting diode (OLED). Nevertheless, the preparation of multicolor long afterglow materials with simple components remains a challenge. This article proposes a general strategy for preparing room temperature long‐lifetime fluorescent polymer materials. This strategy involves doping various fluorescent small molecules containing electron‐donating groups into polymers containing electron‐withdrawing groups. The results show the two components can form charge‐separated state by long‐range charge transfer, and the excitons recombined in fluorescent molecules and emitted long‐lived fluorescence. After photoactivation, the P3COMe film doped with 1% RhB can emit red fluorescent afterglow. The lifetime can achieve 39.4 ms, and the afterglow can last 4.17 s. Meanwhile, by introducing fluorescent molecules with different luminescent colors, the multicolor long‐lifetime fluorescence is also realized. In addition, the influence of the structure of luminescent small molecules on the afterglow fluorescent properties of their doped films is also elucidated.
Polyacrylic Acid‐Coated Selenium‐Doped Carbon Dots Inhibit Ferroptosis to Alleviate Chemotherapy‐Associated Acute Kidney Injury
Authors: Li Jiahuan , Fu Chengcheng , Feng Baoli , Liu Qingquan , Gu Jiangjiang , Khan Mohammad Nauman , Sun Lvhui , Wu Honghong , Wu Hao 
Published: May 2024

AbstractCisplatin‐associated acute kidney injury (AKI) is a severe clinical syndrome that significantly restricts the chemotherapeutic application of cisplatin in cancer patients. Ferroptosis, a newly characterized programmed cell death driven by the lethal accumulation of lipid peroxidation, is widely reported to be involved in the pathogenesis of cisplatin‐associated AKI. Targeted inhibition of ferroptosis holds great promise for developing novel therapeutics to alleviate AKI. Unfortunately, current ferroptosis inhibitors possess low bioavailability or perform non‐specific accumulation in the body, making them inefficient in alleviating cisplatin‐associated AKI or inadvertently reducing the anti‐tumor efficacy of cisplatin, thus not suitable for clinical application. In this study, a novel selenium nanomaterial, polyacrylic acid‐coated selenium‐doped carbon dots (SeCD), is rationally developed. SeCD exhibits high biocompatibility and specifically accumulates in the kidney. Administration of SeCD effectively scavenges broad‐spectrum reactive oxygen species and significantly facilitates GPX4 expression by releasing selenium, resulting in strong mitigation of ferroptosis in renal tubular epithelial cells and substantial alleviation of cisplatin‐associated AKI, without compromising the chemotherapeutic efficacy of cisplatin. This study highlights a novel and promising therapeutic approach for the clinical prevention of AKI in cancer patients undergoing cisplatin chemotherapy.
Analytic Continuation of Multipoint Correlation Functions
Authors: Ge Anxiang , Halbinger Johannes , Lee Seung‐Sup B. , von Delft Jan , Kugler Fabian B. 
Published: May 2024

AbstractConceptually, the Matsubara formalism (MF), using imaginary frequencies, and the Keldysh formalism (KF), formulated in real frequencies, give equivalent results for systems in thermal equilibrium. The MF has less complexity and is thus more convenient than the KF. However, computing dynamical observables in the MF requires the analytic continuation from imaginary to real frequencies. The analytic continuation is well‐known for two‐point correlation functions (having one frequency argument), but, for multipoint correlators, a straightforward recipe for deducing all Keldysh components from the MF correlator had not been formulated yet. Recently, a representation of MF and KF correlators in terms of formalism‐independent partial spectral functions and formalism‐specific kernels was introduced by Kugler, Lee, and von Delft [Phys. Rev. X 11, 041006 (2021)]. This representation is used to formally elucidate the connection between both formalisms. How a multipoint MF correlator can be analytically continued to recover all partial spectral functions and yield all Keldysh components of its KF counterpart is shown. The procedure is illustrated for various correlators of the Hubbard atom.
tert‐Butyl as a Functional Group: Non‐Directed Catalytic Hydroxylation of Sterically Congested Primary C−H Bonds
Authors: Chan Siu‐Chung , Palone Andrea , Bietti Massimo , Costas Miquel 
Published: May 2024

AbstractThe tert‐butyl group is a common aliphatic motif extensively employed to implement steric congestion and conformational rigidity in organic and organometallic molecules. Because of the combination of a high bond dissociation energy (~100 kcal mol−1) and limited accessibility, in the absence of directing groups, neither radical nor organometallic approaches are effective for the chemical modification of tert‐butyl C−H bonds. Herein we overcome these limits by employing a highly electrophilic manganese catalyst, [Mn(CF3bpeb)(OTf)2], that operates in the strong hydrogen bond donor solvent nonafluoro‐tert‐butyl alcohol (NFTBA) and catalytically activates hydrogen peroxide to generate a powerful manganese‐oxo species that effectively oxidizes tert‐butyl C−H bonds. Leveraging on the interplay of steric, electronic, medium and torsional effects, site‐selective and product chemoselective hydroxylation of the tert‐butyl group is accomplished with broad reaction scope, delivering primary alcohols as largely dominant products in preparative yields. Late‐stage hydroxylation at tert‐butyl sites is demonstrated on 6 densely functionalized molecules of pharmaceutical interest. This work uncovers a novel disconnection approach, harnessing tert‐butyl as a potential functional group in strategic synthetic planning for complex molecular architectures.
Innovative Approach to Chiral Polyurethanes: Asymmetric Copolymerization with Isocyanates
Authors: Teng Yong‐Qiang , Ren Bai‐Hao , Liu Ye , Gao Jie , Ren Wei‐Min , Lu Xiao‐Bing 
Published: May 2024

AbstractThe introduction of nitrogen‐containing functional groups to chiral polymer backbones enables the tailoring of physical properties and offers opportunities for further post‐polymerization modification. However, the substrate scope of such polymers is extremely limited because monomers having nitrogen‐containing groups can change coordination state with respect to the metal centers, thus decreasing the activity and enantioselectivity and even poisoning the catalyst completely. In this paper, we report our attempts to carry out the asymmetric copolymerization of meso‐epoxide with highly reactive isocyanates. In particular, we found that biphenol‐linked bimetallic Co(III) complexes with multiple chiral centers are very efficient in catalyzing this asymmetric copolymerization reaction, affording optically active polyurethanes with a completely alternating nature and a high enantioselectivity of up to 94 % ee. Crucially, we identified that the steric hindrance at the phenolate ortho position of the ligand strongly influences the catalytic activity and product enantioselectivity. In addition, density functional theory calculations revealed that the highly sterically bulky substituents change the mechanism from bimetallic to monometallic, and result in the unexpected inversion of the chiral induction direction. Moreover, the high stereoregularity of the produced polyurethanes enhances their thermal stability, and they can be selectively decomposed into oxazolidinones. This study offers a versatile methodology for the synthesis of chiral polymers containing nitrogen functionalities.
Synthesis of Unsymmetrical Trisulfides from S‐Substituted Sulphenylthiosulphates
Authors: Liang Shuaishuai , Ma Liye , Guo Zihao , Liu Fanmin , Lin Zijian , Yi Wenbin 
Published: May 2024

AbstractTrisulfide unit is widely found in natural products and has garnered attention due to the unique pharmacological and physiochemical properties. However, despite limited progress, widely applicable approaches for constructing unsymmetrical trisulfides have so far remain scarce. In this work, an easy‐to‐prepare, solid‐state and scalable reagent, S‐substituted sulphenylthiosulphate, has been developed for the divergent synthesis of unsymmetrical trisulfides. Alkyl electrophile substrates, including bromides, chlorides, iodides and tosylates, with diverse substituents are smoothly converted to the corresponding trisulfides with S‐substituted sulphenylthiosulphates and thiourea as another sulfur source. Furthermore, the late‐stage modification of drug molecules was successfully achieved through this method.
Synergistic effects of miR‐143 with miR‐99a inhibited cell proliferation and induced apoptosis in breast cancer
Authors: Doosti Zahra , Ebrahimi Syed Omar , Ghahfarokhi Mahshid Samie , Reiisi Somayeh 
Published: May 2024

AbstractBreast cancer (BC) is the most common cancer type and the fifth leading cause of cancer‐related deaths. The primary goals of BC treatment are to remove the tumor and prevent metastasis. Despite advances in BC treatment, more effective therapies are required. miRNAs can regulate many targets involved in biological processes and tumor progression; these molecules have emerged as a promising cancer treatment strategy. In the present study, we investigated the effects of miR‐99a and miR‐143 in single expression plasmids for BC inhibition. In this study, the precursor structure of miRNAs in the expression vector pEGFP‐N1 entered single and double states, and MCF7 and T47D cells were transfected. The miRNAs expression level after transfection was then measured using qPCR. The MultiMiR package was used to obtain predicted and validated miRNA targets. MTT assay, qRT‐PCR, migration test, and flow cytometry were used to assess the effect of miRNA and gene modulation. The qPCR results revealed that miRNA constructs were significantly expressed after the transfection of both cell lines. The biological function of miRNAs showed that upregulation of miR‐99a and miR‐143 in any of the two selected BC cells inhibited their proliferation and migration rate, significantly inducing apoptosis (p < 0.01). Also, miR‐99a/miR‐143 co‐treatment has a synergistic anticancer effect in cancer cells via Akt1 and CDK6 targeting. These findings suggest that miR‐99a/miR‐143 plays synergistic regulatory roles in BC, possibly via a shared signaling pathway, providing a therapeutic strategy for BC treatment.
Quantitative detection of mpox antigen using time‐resolved fluorescence immunochromatography
Authors: Liang Huankun , Chen Cuicui , Liu Tiancai , Dong Wenqi , Li Laiqing 
Published: May 2024

AbstractRecently, concern has been raised about the spread of human mpox virus, and the demand for rapid detection reagents for mpox virus has increased. This study aims to establish a time‐resolved fluorescence immunochromatography (TRFICO) method for qualitative/quantitative detection of mpox virus. A double‐antibody sandwich TRFICO method was optimized and established using mpox recombinant fusion antigen and its paired monoclonal antibody. The test performance of the method was evaluated using mpox fusion antigen and control serum, including sensitivity, linearity range, specificity, precision, and reference interval. We successfully established a TRFICO method for qualitative/quantitative detection of mpox antigen, its linearity range 0–100 ng/mL, analytical sensitivity 0.017 ng/mL, and reference intervals greater than 0.045 ng/mL. No cross‐reaction was detected with various poxvirus and clinical negative controls, with good specificity. All average recoveries of the intra‐ and inter‐batch ranged from 81.33% to 97.83%, and all CVs were below 10%. Additionally, the TRFICO strips can be stably stored at 37°C for 7 days without significant changes in the fluorescence intensity. This TRFICO method, with high sensitivity, linearity range, specificity, precision, and stability with 16‐min detection time, provides a new option for qualitative/quantitative and convenient testing of mpox virus.
Effect of IRSL‐BLSL‐TSL reading modes combination on thermoluminescence (TL) response of BeO dosimeter
Authors: Kharfi Faycal , Şahiner Eren , Benkhelifa Chahra‐Zed , Garoui Aymen 
Published: May 2024

AbstractThe ultimate goal of this work is the study of the effect of luminescence stimulations and signals reading modes combinations on the thermoluminescence intensity and glow curve behaviour for the same X‐ray irradiation dose. Three interesting stimulating and reading modes are considered, namely, infrared stimulated luminescence (IRSL), blue light‐emitting diode stimulated luminescence (BLSL) and thermally stimulated luminescence (TSL). The studied stimulation and reading modes combination protocols are (Protocol 1) IRSL‐TSL, (Protocol 2) IRSL‐BLSL‐TSL and (Protocol 3) BLSL‐IRSL‐TSL. Experiments are performed on beryllium oxide (BeO) dosimeter. Results demonstrate well that the combination of reading modes have direct impact on the TL signal in terms of intensity and glow curve shape. It was also found that when reading modes are correctly combined, particularly when IRSL is applied first, then BLSL and TL, it is possible to collect two or more exploitable signals of different stimulation types for the same irradiation that can be used for different purposes and final applications.
Diagnosis and treatment intraorbital foreign body: A case report
Authors: Zhao Hongqing , Feng Hui , Du Lei 
Published: May 2024

Key Clinical MessageWooden foreign bodies inside the eye socket are an uncommon kind of eye injury that falls into a distinct category of intraorbital foreign bodies. Due to the wide range of clinical presentations and imaging features of intraorbital wooden foreign bodies, misinterpretation and failure to diagnose correctly often happen.AbstractWooden foreign bodies inside the eye socket are an uncommon kind of eye injury that falls into a distinct category of intraorbital foreign bodies. The condition mostly manifested in individuals of youthful and middle age. Due to the wide range of clinical presentations and imaging features of intraorbital wooden foreign bodies, misinterpretation and failure to diagnose correctly often happen during the first examination. The risk of orbital infection might greatly rise if there is a delay in diagnosing woody foreign substances inside the eye socket. The majority of patients need surgical intervention as the recommended course of therapy. Nevertheless, it is essential to avoid disregarding undetected diagnoses and the existence of foreign material remnants after prior surgical procedures. Hence, achieving a precise diagnosis relies on a comprehensive assessment of the patient's trauma history, meticulous examination of the eyes, vigilant monitoring of clinical symptoms, accurate imaging techniques such as magnetic resonance imaging (MRI) or computerized tomography (CT), and prompt and thorough removal of wooden foreign objects within the eye socket.
Rheumatic heart disease of the mitral valve alongside the papillary fibroelastoma of the aortic valve: A case report
Authors: Khezerlouy Aghdam Naser , Delkhah Mitra , Danayi Saeid , Sobhi Navid 
Published: May 2024

Key Clinical MessageBesides thromboses, it's crucial to also consider the rare possibility of tumors like papillary fibroelastomas when evaluating worsening cardiopulmonary symptoms in patients with severe rheumatic mitral stenosis and atrial fibrillation.AbstractCardiac papillary fibroelastoma is a rare and benign endocardial tumor typically found on the aortic valve. The simultaneous occurrence of rheumatic heart disease affecting the mitral valve and papillary fibroelastoma on the aortic valve is infrequent, with limited documented instances. This unique case can enhance our understanding of the clinical presentation, diagnostic approaches, management options, and implications for patient outcomes in these two conditions. We present the case of a 47‐year‐old woman who was admitted to the hospital due to worsening dyspnea and fatigue, during which time she discovered an aortic valve papillary fibroelastoma. Further investigations revealed two thrombi in her left atrium and left atrial appendage, along with significant rheumatic mitral valve stenosis. The patient underwent thrombectomy, mitral valve replacement, and valve‐sparing aortic valve tumor resection. Following surgery, the patient's recovery was unremarkable. This case report emphasizes the need for a comprehensive evaluation in patients with rheumatic mitral stenosis, considering all possible etiologies. While thrombi are typical in mitral stenosis and atrial fibrillation, the rare presence of tumors like papillary fibroelastomas should be recognized, underscoring the importance of further assessment when suspicion arises. Importantly, individuals with asymptomatic cardiac papillary fibroelastomas should undergo surgical treatment to minimize the potential risk of tumoral embolization.
Dry needling in the management of chronic tension‐type headache associated with levator scapulae syndrome: A case report
Authors: Gagnon Peter , Dunning James , Bliton Paul , Charlebois Casey , Henry Nathan , Gorby Patrick , Mourad Firas 
Published: May 2024

Key Clinical MessageThe use of DN to the muscular trigger points and distal periosteal enthesis of the levator scapulae may be a useful adjunct intervention within a multi‐modal plan of care for the management of work‐related chronic tension‐type headaches associated with LSS.AbstractChronic tension‐type headaches (CTTH) have a lifetime prevalence of 42% and account for more lost workdays than migraine headaches. Dry needling (DN) is being increasingly used by physical therapists in the management of CTTH; however, to date, the supporting evidence is limited. The purpose of this case report was to describe how three sessions of DN targeting myofascial trigger points in the levator scapulae (LS) muscle and its distal enthesis was used to treat a 63‐year‐old male patient who presented with work‐related CTTH associated with levator scapulae syndrome (LSS). The patient was treated for five visits over the course of 2 months. At discharge and 6‐month follow‐up, the patient reported full resolution of symptoms. Self‐report outcomes included the numeric pain rating scale and the Neck Disability Index. The use of DN to the LS muscle and its distal enthesis may be a valuable addition to a multi‐modal plan of care in the treatment of work‐related CTTH associated with LSS.