bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Cross‐National Comparison of a Shorter Version of the Person's Relating to Others Questionnaire
Authors: Birtchnell John , Hammond Sean , Horn Eva , De Jong Cornelis , Kalaitzaki Argyroula 
Published: September 2011

The shorter version of the Person's Relating to Others Questionnaire (PROQ3) is half the length of the earlier PROQ2. Both questionnaires were designed to measure negative relating as organized around a theoretical structure called the interpersonal octagon. Each questionnaire has an upper, lower, close and distant scale and four intermediate scales (e.g., upper close). As would be expected, moderately high positive correlations were observed between primary scales (upper, lower, close and distant) and neighbouring intermediate scales. Correlations diminished with increasing separation around the octagon. The psychometric properties of the PROQ3 were examined within four national samples. Alpha coefficients were consistently acceptable across samples. Gender differences varied between samples. Comparisons were made between the PROQ3 and a measure of the big five (International Personality Item Pool) and between the PROQ3 and two measures based upon the interpersonal circle (Revised Interpersonal Check List [ICL‐R] and Circumplex Version of the Inventory of Interpersonal Problems [IIP‐C]). It is important to note that, unlike with the PROQ3, significant negative correlations were observed between opposite scales of the ICL‐R and opposite scales of the IIP‐C. A confirmatory factor analysis provided support for most PROQ3 scales, although some overlap between scales was demonstrated. Correlations between the PROQ3 scales and the big five scales were either non‐significant (two scales) or negative. Each PROQ3 scale correlated positively and meaningfully with a short sequence of scales of both the ICL‐R and the IIP‐C. Psychotherapy patients had higher mean scores than non‐patients on four scales but non‐patients had higher mean scores on two. Over the course of psychotherapy, the patients' mean score dropped significantly on six scales but rose significantly on one. Copyright © 2011 John Wiley & Sons, Ltd.Key Practitioner Message

The PROQ3 is an effective self‐rating measure of negative relating.
It is half the length of previous versions of the PROQ but is equally sound psychometrically.
It has been shown to differentiate significantly between psychotherapy patients and non‐patients.
It has revealed a significant reduction in scores over the course of psychotherapy.
It has been successfully translated into other European languages.
Strongyloides stercoralis in bronchoalveolar lavage specimen processed as Prussian Blue Stain
Authors: Zhao Po , Maleki Zahra 
Published: September 2011

AbstractStrongyloidiasis is an infectious disease caused by the nematode helminth, Strogyloides stercoralis. Subjects immunosuppressed, immunocomprised, or on steroids are susceptible to hyperinfection and dissemination. Early detection of parasitic infection in such individuals is extremely important as disseminated Strongyloidiasis is potentially fatal. Here, we present a case of Strongyloidiasis initially detected by Prussian blue stain of bronchoalveolar lavage (BAL) specimen from an immunosuppressed patient who was treated with prednisone for acute interstitial nephritis and developed hemoptysis. Diagn. Cytopathol. 2013. © 2011 Wiley Periodicals, Inc
Fine‐needle aspiration cytology of ameloblastoma and malignant ameloblastoma: A study of 12 cases
Authors: Klapsinou Eirini , Stavros Archondakis , Smaragda Angeli , Despoina Proestou , Dimitra Daskalopoulou 
Published: September 2011

AbstractAmeloblastoma is an odontogenic tumor with aggressive biological behavior, high recurrence rate, and a complex microscopic appearance with many different histologic patterns. Primary ameloblastoma is also described in extragnathic locations. Because of its wide morphologic spectrum, which is mirrored also in cytologic smears, a thorough study of distinctive features is required to reach a reliable diagnosis. Twelve cases of ameloblastoma were examined both cytologically and histologically. The patients were seven women and five men 24–85 years old, mean age being 64 years. Eleven cases were primary tumors of the mandible and maxilla, and one case was a lung tumor metastatic from the tibia. The epithelial element in the cytologic smears of the various cases was morphologically diverse. The basaloid pattern and minimal nuclear atypia were rather constant findings, and the most helpful features toward reaching a cytological diagnosis. However in most cases, careful consideration of the clinical, radiological, cytological, and occasionally immunocytochemical data was required to rule out other entities with similar cytological findings. In some cases, the final diagnosis was only possible by histologic examination. Due to their variable microscopic morphology, ameloblastomas are quite often misdiagnosed for other entities, both benign and malignant. Nevertheless, when one is aware of their distinctive features, an accurate diagnosis can be made by fine‐needle aspiration cytology, in conjunction with clinical and radiological findings. Both the preoperative surgical planning and the postoperative follow‐up of the patients benefit significantly from this method. Diagn. Cytopathol. 2013. © 2011 Wiley Periodicals, Inc.
Trait‐mediated diversification in nematode predator–prey systems
Authors: Mulder Christian , Helder Johannes , Vervoort Mariëtte T. W. , Arie Vonk J. 
Published: September 2011

AbstractNematodes are presumably the most numerous Metazoans in terrestrial habitats. They are represented at all trophic levels and are known to respond to nutrient limitation, prey availability, and microbial resources. Predatory nematodes reside at the highest trophic level, and as such their feeding habits could have a major impact on soil food web functioning. Here, we investigate the effects of gender and developmental stage on the nematode body sizes in coarse and loamy soils. Besides Neodiplogasteridae, our predators are much larger than other soil‐dwelling nematodes from their early developmental stage onwards. From juvenile to adult, the predatory Aporcelaimellus (Kruskal–Wallis P < 0.001), Dorylaimoides, and Tripyla (both P < 0.01) show great length increases during their developmental growth, in contrast to their possible prey (almost all P < 0.001). Less than 4% of the prey exceeds the length of the predatory adults, but more than 30% of the prey exceeds the length of the predatory juveniles. Potential body size ratios and some physical problems experienced by small fluid feeders attacking large prey are discussed in an attempt to summarize different prey‐searching mechanisms and aggregative predatory responses in the soil system.
Impairments in life quality among clients in geriatric home care: associations with depressive and anxiety symptoms
Authors: Diefenbach Gretchen J. , Tolin David F. , Gilliam Christina M. 
Published: September 2011

ObjectiveThe aim of this study was to determine the independent contributions of depressive and anxiety symptoms to quality of life among older adults who were receiving services through a home care program.MethodsThe study sample consisted of 66 community‐dwelling older adults (ages 65 years and older), who were experiencing chronic medical illness and concomitant functional disability necessitating home care. Participants completed self‐report measures of depression, anxiety, and health‐related quality of life. Additional data on cognitive, health, and functional status were collected to be used as covariates.ResultsThe associations of depressive symptoms with quality of life impairments in home care were substantial and pervasive. Depressive symptoms were significantly associated with quality of life impairments in nearly all domains. After controlling for depressive symptoms, anxiety symptoms accounted for additional and statistically significant variance in impaired life quality in the domains of mental health, role emotional functioning, and bodily pain.ConclusionsThese results indicate that depressive and anxiety symptoms demonstrate negative associations with life quality among older adults in home care and highlight the importance of developing community‐based programs to assess and treat depressive and anxiety symptoms among home care clients. Copyright © 2011 John Wiley & Sons, Ltd.
Functional outcomes after radiotherapy or laser surgery in early glottic carcinoma: A systematic review
Authors: van Loon Yda , Sjögren Elisabeth V. , Langeveld Ton P. M. , Baatenburg de Jong Rob J. , Schoones Jan W. , van Rossum Maya A. 
Published: September 2011

AbstractBackgroundEarly glottic carcinoma is treated with laser surgery or radiotherapy, but which treatment has better functional outcomes is unclear. This systematic review compared functional outcomes (voice, swallowing, quality of life [QOL]) in more extended T1a and limited T2 tumors (1) between treatments and (2) between greater and lesser laser resections.MethodsA systematic literature search covered relevant databases from 1990 to 2009, combining all patient/problem, intervention, comparison, outcome (PICO) keyword variations.ResultsA total of 19 papers met the inclusion criteria, all of which were level IV evidence. Papers reported only voice and QOL. Heterogeneity of outcome measures prevented data pooling. Uncertainty about tumor comparability (depth, extent) between the 2 treatments, small subject numbers, and poor‐quality reporting hindered interpretation.ConclusionsTo allow comparison of laser surgery versus radiotherapy, a standardized method is needed that accurately measures tumor extent and depth. Agreement on functional outcome measures is necessary to allow comparison of treatments and resection types. Multicenter studies should be encouraged to guarantee adequate subject numbers. © 2011 Wiley Periodicals, Inc. Head Neck, 2012
Cervical cancer screening among HIV‐infected women: An economic evaluation in a middle‐income country
Authors: Vanni Tazio , Luz Paula Mendes , Grinsztejn Beatriz , Veloso Valdilea G. , Foss Anna , Mesa‐Frias Marco , Legood Rosa 
Published: September 2011

AbstractDue to the recent widespread availability of highly active antiretroviral therapy (HAART) in middle‐income countries, there has been an increase in life expectancy for women on HAART, but no corresponding decrease in cervical cancer incidence. This study evaluates the optimal cervical cancer screening strategy for HIV‐infected women in a middle‐income country. We developed a mathematical model, which simulates the natural history of the HPV infection, as well as the HIV‐mediated immunosupression among women in Brazil. Our model was calibrated using data from the IPEC/FIOCRUZ Women's HIV‐infected cohort. The model compares the lifetime effects, costs and cost‐effectiveness of strategies combining cytology, HPV DNA test and colposcopy at different screening intervals for different CD4 count strata (27 strategies in total). We found that the strategy with the best cost‐effectiveness profile (cost‐effectiveness ratio–U$4,911/year of life saved [YLS] and probability of being cost‐effective–86%) was HPV testing followed by cytology triage every year for all HIV infected women, considering a very cost‐effective threshold given by Brazil's GDP per capita (US$8,625/YLS). The results were robust to changes in the input parameters as demonstrated in one‐way, scenario, threshold and probabilistic sensitivity analysis. Our study indicates that annual HPV testing followed by cytology triage for all HIV‐infected women is likely to be very cost‐effective in a middle‐income country like Brazil. The results reflect the synergic effect of using a highly sensitive screening test (HPV DNA test) in sequence with a highly specific test (cytology).
Potential role of Hsp90 inhibitors in overcoming cisplatin resistance of bladder cancer‐initiating cells
Authors: Tatokoro Manabu , Koga Fumitaka , Yoshida Soichiro , Kawakami Satoru , Fujii Yasuhisa , Neckers Len , Kihara Kazunori 
Published: September 2011

AbstractFor metastatic bladder cancer patients, systemic cisplatin (CDDP)‐based combination chemotherapy is the first‐line choice of treatment. Although up to 70% of advanced bladder cancer patients initially show good tumor response to this form of combination chemotherapy, over 90% of good responders relapse and eventually die of the disease. According to the cancer stem cell theory, this phenomenon is attributable to the re‐growth of bladder cancer‐initiating cells (BCICs) that have survived chemotherapy. In this study, the authors have isolated BCICs from cultured human bladder cancer cells to analyze their sensitivity to CDDP and to investigate whether heat‐shock protein 90 (Hsp90) inhibitors potentiate the cytotoxicity of CDDP on BCICs. First, the authors have confirmed that a CD44+ subpopulation of 5637 cells met the requirements to be considered tumor‐initiating cells. These BCICs were more resistant to CDDP and exhibited more activity in the Akt and ERK oncogenic signaling pathways when compared with their CD44− counterparts. The Hsp90 inhibitor 17‐(dimethylaminoethylamino)‐17‐demethoxygeldanamycin (17‐DMAG), which simultaneously inactivated both Akt and ERK signaling at noncytocidal concentrations, synergistically potentiated the cytotoxicity of CDDP against BCICs by enhancing CDDP‐induced apoptosis in vitro. The potentiating effect of 17‐DMAG was more effective than a combination of the two inhibitors specific for the Akt and ERK pathways. Finally, the authors have confirmed that, though human BCIC xenografts exhibited resistance to a single administration of CDDP and the Hsp90 inhibitor 17‐(allylamino)‐17‐demethoxygeldanamycin (17‐AAG), 17‐AAG sensitized them to CDDP in a mouse model. These data encourage clinical trials of Hsp90 inhibitors as they may improve therapeutic outcomes of CDDP‐based combination chemotherapy against advanced bladder cancer.
Structural and molecular biology of type I galactosemia: Disease‐associated mutations
Authors: McCorvie Thomas J. , Timson David J. 
Published: September 2011

AbstractType I galactosemia results from reduced galactose 1‐phosphate uridylyltransferase (GALT) activity. Signs of disease include damage to the eyes, brain, liver, and ovaries. However, the exact nature and severity of the pathology depends on the mutation(s) in the patient's genes and his/her environment. Considerable enzymological and structural knowledge has been accumulated and this provides a basis to explain, at a biochemical level, impairment in the enzyme in the more than 230 disease‐associated variants, which have been described. The most common variant, Q188R, occurs close to the active site and the dimer interface. The substitution probably disrupts both UDP‐sugar binding and homodimer stability. Other alterations, for example K285N, occur close to the surface of the enzyme and most likely affect the folding and stability of the enzyme. There are a number of unanswered questions in the field, which require resolution. These include the possibility that the main enzymes of galactose metabolism form a supramolecular complex and the need for a high resolution crystal structure of human GALT. © 2011 IUBMB IUBMB Life, 63(11): 949–954, 2011
Performance of a fully automatic lesion detection system for breast DCE‐MRI
Authors: Vignati Anna , Giannini Valentina , De Luca Massimo , Morra Lia , Persano Diego , Carbonaro Luca A. , Bertotto Ilaria , Martincich Laura , Regge Daniele , Bert Alberto , Sardanelli Francesco 
Published: September 2011

AbstractPurpose:To describe and test a new fully automatic lesion detection system for breast DCE‐MRI.Materials and Methods:Studies were collected from two institutions adopting different DCE‐MRI sequences, one with and the other one without fat‐saturation. The detection pipeline consists of (i) breast segmentation, to identify breast size and location; (ii) registration, to correct for patient movements; (iii) lesion detection, to extract contrast‐enhanced regions using a new normalization technique based on the contrast‐uptake of mammary vessels; (iv) false positive (FP) reduction, to exclude contrast‐enhanced regions other than lesions. Detection rate (number of system‐detected malignant and benign lesions over the total number of lesions) and sensitivity (system‐detected malignant lesions over the total number of malignant lesions) were assessed. The number of FPs was also assessed.Results:Forty‐eight studies with 12 benign and 53 malignant lesions were evaluated. Median lesion diameter was 6 mm (range, 5–15 mm) for benign and 26 mm (range, 5–75 mm) for malignant lesions. Detection rate was 58/65 (89%; 95% confidence interval [CI] 79%–95%) and sensitivity was 52/53 (98%; 95% CI 90%–99%). Mammary median FPs per breast was 4 (1st–3rd quartiles 3–7.25).Conclusion:The system showed promising results on MR datasets obtained from different scanners producing fat‐sat or non–fat‐sat images with variable temporal and spatial resolution and could potentially be used for early diagnosis and staging of breast cancer to reduce reading time and to improve lesion detection. Further evaluation is needed before it may be used in clinical practice. J. Magn. Reson. Imaging 2011;. © 2011 Wiley Periodicals, Inc.
Dynamic physostigmine effects on hippocampus perfusion
Authors: Li Xiufeng , Spence Jeffrey S. , Buhner David M. , Haley Robert W. , Briggs Richard W. 
Published: September 2011

AbstractPurpose:To characterize the dynamic response of hippocampus blood flow to physostigmine infusion and to determine an infusion duration sufficiently long for robust detection of effects with arterial spin labeling (ASL) and sufficiently short to avoid peripheral side effects of physostigmine.Materials and Methods:Two female (49 ± 15 years) and nine male (53 ± 13 years) subjects were studied to determine the time course of the physostigmine effect on hippocampus blood flow with ASL perfusion imaging during 20 minutes of baseline, 30 minutes of physostigmine infusion at 1.0 mg/hr, and 70 minutes of recovery.Results:Hippocampus perfusion decreased steadily over the course of the infusion, with the reduction in flow becoming significant after 20 minutes of infusion, reaching lowest levels near the end of infusion, and remaining significantly low and stable in the 70‐minute recovery period. Percentage changes of hippocampus perfusion were −13.3%, −13.4%, and −13.4% for left, right, and bilateral hippocampus, respectively, at the end of infusion.Conclusion:At a dose rate of 1.0 mg/hr it is feasible to use an infusion time as short as 20 minutes, performing perfusion imaging up to an hour after physostigmine infusion is discontinued, to minimize chances for adverse side effects. J. Magn. Reson. Imaging 2012;280‐286. © 2011 Wiley Periodicals, Inc.
Recent Advances in the Covalent Modification of Graphene With Polymers
Authors: Salavagione Horacio J. , Martínez Gerardo , Ellis Gary 
Published: September 2011

AbstractCovalent binding of polymers to graphene represents an interesting alternative for the development of novel composite materials with a compendium of interfacial interactions. Through covalent linking, the concept of interface changes from a traditional view of interactions between components, such as van der Waals, hydrogen bonding, and so on, that is to say, at a polymer–filler interface, to a single compound concept where graphene forms an integral part of the polymeric chains. This feature article provides an overview of the strategies currently employed to functionalize graphene with polymers. We focus on the grafting‐from and grafting‐to methods used to bind polymers to graphene. The advantages and drawbacks, as well as the influence of each method on the final properties, are highlighted.
The ℓp‐function on trees
Authors: McMorris F. R. , Mulder Henry Martyn , Ortega O. 
Published: September 2011

AbstractA p‐value of a sequence π = (x1, x2,…, xk) of elements of a finite metric space (X, d) is an element x for which
\documentclass{article}\usepackage{mathrsfs}\usepackage{amsmath}\pagestyle{empty}\begin{document}$\sum_{i=1}^{k}d^p(x,x_i)$\end{document}
is minimum. The function ℓp with domain the set of all finite sequences defined by ℓp(π) = {x: x is a p‐value of π} is called the ℓp‐function on X. The ℓp‐functions with p = 1 and p = 2 are the well‐studied median and mean functions respectively. In this article, the ℓp‐function on finite trees is characterized axiomatically. © 2011 Wiley Periodicals, Inc. NETWORKS, 2012
New facets and an enhanced branch‐and‐cut for the min–max K‐vehicles windy rural postman problem
Authors: Benavent Enrique , Corberán Angel , Plana Isaac , Sanchis José M. 
Published: September 2011

AbstractThe min–max windy rural postman problem is a multiple vehicle version of the windy rural postman problem, WRPP, which consists of minimizing the length of the longest route to find a set of balanced routes for the vehicles. In a previous paper, an ILP formulation and a partial polyhedral study were presented, and a preliminary branch‐and‐cut algorithm that produced some promising computational results was implemented. In this article, we present further results for this problem. We describe several new facet‐inducing inequalities obtained from the WRPP, as well as some inequalities that have to be satisfied by any optimal solution. We present an enhanced branch‐and‐cut algorithm that takes advantage of both these new inequalities and high quality min–max K‐WRPP feasible solutions obtained by a metaheuristic. Computational results on a large set of instances are also reported. © 2011 Wiley Periodicals, Inc. NETWORKS, Vol. 58(4), 255–272 2011
Development of a Rapid Resolution Liquid Chromatographic Method Combined with Chemometrics for Quality Control of Angelicae dahuricae radix
Authors: Fan Gang , Deng Rui , Zhou Lin , Meng Xianli , Kuang Tingting , Lai Xianrong , Zhang Jing , Zhang Yi 
Published: September 2011

ABSTRACTIntroductionAngelicae dahuricae radix (Baizhi) is a widely used traditional Chinese medicine, for which the traditional processing method has been sun‐drying after harvesting. In recent years this method has been replaced by sulphur‐fumigation for the sake of improving its appearance and pest control. Correct identification of sulphur‐fumigated Baizhi and rapid finding of appropriate chemical markers for the quality control of Baizhi are of very great importance.ObjectiveTo develop a rapid and efficient method of rapid resolution liquid chromatography (RRLC) combined with chemometrics for discriminating sulphur‐fumigated Baizhi and controlling its quality.MethodologyThe samples were separated on a Zorbax SB‐C18‐column with a gradient elution programme using methanol and water. The optimal RRLC method was validated in terms of linearity, precision, stability and recovery test. In addition, hierarchical clustering analysis (HCA) and principle component analysis (PCA) were applied to differentiate the different samples.ResultsAll the constituents were well separated within 18 min. The results of chemical fingerprinting and quantitative analysis showed that the sulphur‐fumigated method obviously destroyed the phytochemical profiles of Baizhi. Moreover, the sun‐dried and sulphur‐fumigated Baizhi could be clearly separated by HCA and PCA, and the critical markers such as oxypeucedanin and imperatorin accountable for such differences were ultimately screened out.ConclusionThis study revealed that sulphur‐fumigation is an inappropriate approach for processing crude drugs and should be prohibited, and that the proposed RRLC method combined with chemometrics demonstrated an efficient strategy for quality control of Baizhi. Copyright © 2011 John Wiley & Sons, Ltd.