bluuebunny/crossref_metadata_2025_split huggingface dataset:
To Know Thyself Through the Other: The Literary Convergences of Lucian and Justin
Authors: Bozia Eleni 
Published: May 2024

Abstract
The paper engages in a comparative analysis of two prominent figures from the 2d century CE—Lucian of Samosata and Justin the Martyr. Lucian, the epideictic orator and social commentator, reintroduces the Olympians while rethinking paganism and engaging with Justin and the Apologists. Conversely, Justin, embodying the Christian pepaideumenos, places the new religion at the literary forefront and questions the stereotype of Christian simplicity. The paper argues that, in the context of reformative, paideutic Imperial culture, Lucian and Justin challenge the literary and religious status quo and engage the readers in a reconsideration of Christianity through the lens of the Second Sophistic and vice versa.
Development and assessment of novel pyrazole–thiadiazol hybrid derivatives as VEGFR-2 inhibitors: design, synthesis, anticancer activity evaluation, molecular docking, and molecular dynamics simulation
Authors: Halimi Gresa , Osmaniye Derya , Özkay Yusuf , Kaplancıklı Zafer Asım 
Published: May 2024

Abstract
Cancer remains a significant health challenge globally, requiring the development of targeted chemotherapeutics capable of specifically inhibiting cancer cell growth. Angiogenesis is one of the key features of tumor growth and metastasis and is, therefore, an important target for the treatment of many tumors. The vascular endothelial growth factor (VEGF) signaling pathway has proven to be a promising lead in anticancer therapy due to the central role it plays in tumor angiogenesis. Vascular endothelial growth factor receptor-2 (VEGFR-2) is a key mediator in the signaling pathway regulating angiogenesis. Targeting VEGFR-2 may disrupt angiogenesis, leading to a reduction in tumor blood supply and tumor progression. The design, synthesis, and assessment of novel VEGFR-2 inhibitor derivatives are the focus of this study, with particular emphasis on incorporating the pyrazole–thiadiazol pharmacophore into the molecular structure. Taking advantage of the pharmacophoric properties of pyrazole and 1,3,4-thiadiazol, compounds with different substituents in the main structure were designed and synthesized. The compounds were also evaluated for antiproliferative activity against cancer cell lines. Compound 4e demonstrated the highest activity among all compounds, with an IC50 of 9.673 ± 0.399 μM against HT-29 cells and 23.081 ± 0.400 μM against NIH3T3 cells. To further support the inhibitory activity of compound 4e, an in silico study was performed. Compound 4e demonstrated strong binding to the active site of VEGFR-2 in molecular docking studies, forming hydrogen bonds with key amino acid residues. The stability of the compound in the enzyme’s active site was demonstrated through molecular dynamics simulations.
Politik Identitas Dalam Pemilu dan Pengaruhnya Terhadap Demokrasi di Indonesia
Authors: Aidah Nur Lailatul , Rochmadian Sindy , Maliha Usna 
Published: May 2024

Penelitian ini membahas mengenai munculnya politik identitas pada penyelenggaraan pemilu di Indonesia, dimana kemunculan politik identitas ini disebabkan adanya perbedaan agama, suku, adat dan lainnya yang dimana salah satu kelompok-kelompok tertentu merasa di intimidasi dan di diskriminasi oleh para pihak-pihak yang lain, sehingga menimbulkan banyak masalah bagi masyarakat Indonesia yaitu salah satunya rengangnya persaudaraan antar negara dikarenakan adanya perbedaan dari satu sama yang lain, sehingga membuat demokrasi di negara Indonesia ini tidak bekerja dengan baik atau bahkan tidak berguna sama sekali. Indonesia merupakan negara yang banyak memiliki suku, pulau, atau bahkan adat sehingga membuat Indonesia berbeda dari negara-negara yang lain yang bisa menjadi kebanggaan masyarakat, akan tetapi menjadi salah satu penyebab terbesar terjadinya resiko terpecah belahnya masyarakat Indonesia dikarenakan timbulnya politik identitas ini, sehingga ketika terjadi pemilu masyarakat yang memiliki kesempatan untuk memilih lebih banyak melakukan golput karena merasa bakal calon yang dipilih tidak memiliki kesamaan identitas entah mulai dari suku, adat, atau bahkan agama. Saat ini politik identitas semakin menjadi karena tidak adanya tindakan yang dapat menyadarkan masyarakat mengenai politik identitas ini, sehingga banyak masyarakat yang menganggap sepele kejadian tersebut atau bahkan mereka tidak sadar sama sekali mengenai politik identitas.
Análisis cualitativo de la ecuación logística en el campo educativo
Authors: Quilantán-Ortega Ingrid , Rodríguez-Vásquez Flor Monserrat 
Published: May 2024

Introducción. La educación matemática universitaria, ha debido transformarse en sus métodos de enseñanza-aprendizaje para orientarse, tanto en los contenidos académicos y la transmisión de saberes, como en el desarrollo integral del ser humano para atender las problemáticas actuales de la sociedad. La ecuación logística, permite modelar diversos fenómenos en diversas áreas científicas e incidir en la mejora de estas problemáticas. Dado que es de gran utilidad en diversos contextos científicos planteamos la necesidad de mostrar un panorama amplio y detallado acerca de ésta, sobre todo en el plano de la enseñanza-aprendizaje de la matemática, ya que, en el contexto escolar, algunos estudiantes muestran dificultades relacionadas con su comprensión. Objetivo. Mostrar una revisión sistemática de las investigaciones que se han realizado sobre la ecuación logística desde el campo de la matemática educativa. Análisis. El periodo para analizar comprende del año 2000 a 2022, considerando aquellos documentos que tratan de la ecuación logística en la educación. Metodología. Para recolectar y analizar los datos se usó el análisis cualitativo de texto de Kuckartz. Resultados. Las principales dificultades relacionadas con la ecuación logística son en el uso de las distintas representaciones, en el aprendizaje como ecuación diferencial, así como dificultades en la comunicación interdisciplinar. Las propuestas didácticas en atención a dichas dificultades hacen uso de distintos enfoques, herramientas tecnológicas y marcos teóricos diversos. Conclusiones. Considerando la vasta aplicabilidad de la ecuación logística, se plantea que la modelación matemática es una de las principales estrategias metodológicas de aprendizaje de esta ecuación y sus conceptos relacionados.
Dicer-Mediated mTORC1 Signaling and Parathyroid Gland Integrity and Function
Authors: Hassan Alia , Khalaily Nareman , Kilav-Levin Rachel , Del Castello Barbara , Manley Nancy Ruth , Ben-Dov Iddo Z. , Naveh-Many Tally 
Published: May 2024

Key Points

Maintaining parathyroid gland integrity is a dynamic process regulated by the parathyroid microRNA–mechanistic target of rapamycin complex 1 axis.This axis is essential for preserving intact parathyroid glands throughout life, with relevance to CKD-induced secondary hyperparathyroidism.

Background
Secondary hyperparathyroidism of CKD contributes significantly to patient morbidity and mortality. The underlining mechanisms of CKD-induced secondary hyperparathyroidism remain elusive. We previously demonstrated that PT-Dicer

−/−
mice, with parathyroid-specific deletion of the microRNA (miRNA)-processing enzyme Dicer and consequently miRNA, maintain normal basal serum parathyroid hormone (PTH) levels but do not develop secondary hyperparathyroidism induced by CKD. In addition, we showed that the parathyroid mechanistic target of rapamycin complex 1 (mTORC1) pathway is activated in CKD. We now explored the roles of Dicer/miRNA and mTORC1 in parathyroid development and function.

Methods
We generated mice with parathyroid-specific Dicer (PT-Dicer

−/−
), mechanistic target of rapamycin (PT-mTOR

−/−
), or tuberous sclerosis complex 1 (PT-Tsc1

−/−
) deficiency combined with yellow fluorescent protein (YFP) or tdTomato expression to identify the parathyroids by fluorescence microscopy. CKD was induced by an adenine-rich high-phosphate diet.

Results
Despite normal basal serum PTH levels, PT-Dicer

−/−
mice displayed apoptotic loss of intact parathyroid glands postnatally and reduced mechanistic target of rapamycin activity. PT-mTOR

−/−
mice lacked intact parathyroid glands yet maintained normal serum PTH levels, mirroring the phenotype of PT-Dicer

−/−
mice. Conversely, PT-Tsc1

−/−
mice with hyperactivated mTORC1 exhibited enlarged glands along with elevated basal serum PTH and calcium levels. Significantly, PT-Dicer

−/−

;Tsc1

−/−
double knockout mice preserved intact parathyroid glands and reinstated CKD-induced secondary hyperparathyroidism.

Conclusions
mTORC1 operates downstream of Dicer and miRNA in the parathyroid and is essential for maintaining postnatal parathyroid gland integrity throughout life and for the pathogenesis of CKD-induced secondary hyperparathyroidism.
The Arens-Calderon theorem for commutative topological algebras
Authors: Weigt M. , Zarakas I. 
Published: May 2024

A theorem of Arens and Calderon states that if A is a commutative Banach algebra with Jacobson radical Rad(A), and if a0 , . . . , an∈ A with a0 ∈ Rad(A) and a1 an invertible element of k A, then there exists y ∈ Rad(A) such that Σ ak yk = 0. In this paper, we give extensions of this result to commutative non-normed topological algebras, as this is vital for extending an embedding theorem of Allan in [2] regarding the embedding of the formal power series algebra C[[X]] into a commutative Banach algebra.
Medicolegal Mindbenders Forensic Medicine and Toxicology- Exclusive Question Archive
Authors: Thakral Dr. Sahil 
Published: May 2024

This Exclusive Question Archive is not just a study tool; it's a visionary learning resource crafted to empower students in their journey through the intricate landscape of Forensic Medicine and Toxicology.

Salient Features:

Chapter-wise Question Structure
Expertly Crafted Questions
Mock Tests for Exam Simulation
Tabular Comparison

BNS with IPC
BNSS with CrPC
BNA with IEA
Is It the same Boat? Sailing the Interdisciplinarity of Entrepreneur(ship) and Leader(ship) Nexus: Romanian Migrants Stirring Transformational Leadership in London
Authors: Chitac Iuliana , Agheorghiesei Daniela 
Published: May 2024

To fully understand the transformative leadership potential inherent in the entrepreneurial practices of migrant entrepreneurs, it is crucial for readers of this study to go beyond the common stereotypes of instability and economic survival often associated with migrant entrepreneurship. This study employs interpretive constructivism to investigate transformational leadership identities and practices shared by 16 Romanian immigrant entrepreneurs in London on Facebook and via semi-structured interviews. The participants shared their practices as transformational leaders within their communities and in broader British society. This study draws on theories of Social Identity and self-efficacy (Tajfel & Turner, 1979) and Leader-Follower (Graen & Cashman, 1975) to enhance our comprehension of how entrepreneurs enacted idealised influence, inspirational motivation, intellectual stimulation, and individualised consideration to motivate and inspire stakeholders towards a broader focus on social positive impact rather than solely economic outcomes. This study focuses on Romanian immigrant entrepreneurs and contributes to the interdisciplinary understanding of transformational leadership through entrepreneurship. It facilitates the shift from belief-driven policies to evidence-driven policies that promote and support the inclusivity of entrepreneurs and leaders.
Le plafonnement de carrière : source de stress au travail dans les grandes entreprises au Cameroun
Authors: Innocent Essomme 
Published: May 2024

Cette étude montre les effets du plafonnement de carrière sur les manifestations de stress professionnel des employés dans les grandes entreprises camerounaises. Une enquête par questionnaire a été réalisée auprès de 291 employés de ces entreprises. L’analyse descriptive a permis de montrer les spécificités du plafonnement de carrière dans les grandes entreprises camerounaises. Le test de corrélation de Pearson effectué a permis d’aboutir aux résultats montrant que le plafonnement de carrière dans les grandes entreprises camerounaises n’a pas un effet systématique sur toutes les facettes du stress professionnel. Toutefois, ceux qui sont subjectivement plafonnés ont une perception négative de la réalité, sont très anxieux au sujet de leur avenir dans l’entreprise, ont des vertiges au travail et ont tendance à s’isoler. Nous recommandons aux dirigeants de ces entreprises de favoriser l’employabilité des personnes plafonnés ; de donner une place importante au suivi-évaluation des pratiques de gestion des carrières implémentées dans leurs entreprises et enfin, d’organiser régulièrement des séminaires d’information et de formation sur la gestion des carrières au sein de l’entreprise.

This study shows the consequences of career plateauing on the professional stress experienced by large companies in Cameroon employees. A questionnaire survey of 291 employees of these companies was conducted. Descriptive analysis revealed the specific characteristics of career plateauing in large Cameroonian companies. The Pearson correlation test showed that career plateauing in large Cameroonian companies does not systematically affect all manifestations of work-related stress. However, those who feel blocked in their progress have a negative perception of reality, are very anxious about their future in the company, feel dizzy at work and tend to isolate themselves. We recommend that the managers of these companies promote the employability of people with ceilings; give an essential place to the monitoring and evaluation of the career management practices implemented in their companies; and finally, organise regular information and training seminars on career management within the company.
Possibilities of Increasing the Ampacity of Overhead Lines Using HTLS Conductors in the Electric Power System of the Slovak Republic
Authors: Margita Frantisek , Bena Lubomir , Malska Wiesława , Pijarski Paweł 
Published: May 2024

The examination of ampacity in overhead transmission lines offers a comprehensive overview, covering its definition, thermal evaluation methodologies, standards, practical applications, and the potential of high-temperature low-sag (HTLS) conductors. By navigating through static and dynamic approaches to thermal evaluation and detailing methodologies prescribed by international standards like those from CIGRE and IEEE, this study provides a solid understanding of how ampacity is determined and optimized. Furthermore, the exploration of HTLS conductors introduces a forward-looking perspective on enhancing transmission capacity whereas mitigating the need for extensive infrastructure modifications. Through an analysis of regional considerations and preferences using Slovak standards and CIGRE Technical Brochure 601, insights are provided on how environmental factors influence transmission line performance. The analysis of the transition from traditional ACSR to advanced ACCC (Aluminium Conductor Composite Core) conductors demonstrates the tangible benefits of adopting advanced conductor technologies in real-world scenarios.
Validating Orthopaedic Data Evaluation Panel (ODEP) Ratings Across 9 Orthopaedic Registries
Authors: Hoogervorst Lotje A. , van Tilburg Maartje M. , Lübbeke Anne , Wilton Tim , Nelissen Rob G.H.H. , Marang-van de Mheen Perla J. 
Published: May 2024

Background:
Orthopaedic Data Evaluation Panel (ODEP) ratings of total hip (TH) and total knee (TK) implants are informative for assessing implant performance. However, the validity of ODEP ratings across multiple registries is unknown. Therefore, we aimed to assess, across multiple registries, whether TH and TK implants with a higher ODEP rating (i.e., an A* rating) have lower cumulative revision risks (CRRs) than those with a lower ODEP rating (i.e., an A rating) and the extent to which A* and A-rated implants would be A*-rated on the basis of the pooled registries’ CRR.

Methods:
Implant-specific CRRs at 3, 5, and 10 years that were reported by registries were matched to ODEP ratings on the basis of the implant name. A meta-analysis with random-effects models was utilized for pooling the CRRs. ODEP benchmark criteria were utilized to classify these pooled CRRs.

Results:
A total of 313 TH cups (54%), 356 TH stems (58%), 218 TH cup-stem combinations (34%), and 68 TK implants (13%) with unique brand names reported by registries were matched to an ODEP rating. Given the low percentage that matched, TK implants were not further analyzed. ODEP-matched TH implants had lower CRRs than TH implants without an ODEP rating at all follow-up time points, although the difference for TH stems was not significant at 5 years. No overall differences in CRRs were found between A* and A-rated TH implants, with the exception of TH cup-stem combinations, which demonstrated a significantly lower CRR for A*A*-rated cup-stem combinations at the 3-year time point. Thirty-nine percent of A*-rated cups and 42% of A*-rated stems would receive an A* rating on the basis of the pooled registries’ CRR at 3 years; however, 24% of A-rated cups and 31% of A-rated stems would also receive an A* rating, with similar findings demonstrated at longer follow-up.

Conclusions:
At all follow-up time points, ODEP-matched TH implants had lower CRRs than TH implants without an ODEP rating. Given that the performance of TH implants varied across countries, registries should first validate ODEP ratings with use of country-specific revision data to better guide implant selection in their country. Data source transparency and the use of revision data from multiple registries would strengthen the ODEP benchmarks.

Level of Evidence:
Therapeutic Level III. See Instructions for Authors for a complete description of levels of evidence.
Post-tubercular Lumbosacral Kyphotic Deformity in a 11-Year-Old Child
Authors: Mahajan Rajat , Goswami Sutanu , Kumar Ganesh S. 
Published: May 2024

Case:
An 11-year-old girl with intact neurology presented with a lumbosacral kyphotic deformity due to healed tuberculosis. Radiological imaging showed sagittal balanced spine with compensatory thoracic lordosis and cervical kyphosis. She underwent L4 and L5 posterior vertebral column resection (PVCR) with posterior instrumentation from L2 to pelvis. The patient demonstrated immediate correction of compensatory curves postoperatively. At 3-year follow-up, she returned to her activities of daily living with Oswestry Disability Index and Scoliosis Research Society scores of 12 and 4.8% respectively.

Conclusion:
Pediatric post-tubercular deformities in the lumbosacral region are rare. They can cause secondary changes in other regions, such as the loss of thoracic kyphosis or cervical lordosis. These deformities should be addressed at an early age to prevent structural changes in compensatory curves.
Duplex RTqPCRs for detection and relative quantification of SARS-CoV-2 variants of concern (VOC)
Authors: Carcereny Albert , Garcia-Pedemonte David , Bosch Albert , Pintó Rosa M , Guix Susana 
Published: May 2024

Abstract

During the evolution of the SARS-CoV-2 pandemic, new variants of the virus have emerged and spread worldwide. The increased transmissibility and proclivity of some of these variants to cause more serious disease threatens public health responses against the virus, thus being its monitoring relevant. While Next-Generation-Sequencing (NGS) is the gold standard to identify variants, it cannot always be rapidly implemented in some settings to provide information as an early warning tool. Duplex quantitative real time RTqPCR assays offer a sensitive and easy-to-use tool to detect, discriminate, and estimate relative proportions of SARS-CoV-2 variants containing signature mutations from variants lacking it, using allelic discrimination probes. We developed ten multiplexed RTqPCR assays that can detect Alpha (B.1.1.7), Beta (B.1.351), Gamma (P.1), Delta (B.1.617.2), Omicron (B.1.1.529), Omicron BA.1 (B.1.1.529.1), Omicron BA.2 (B.1.1.529.2), Omicron FLip (XBB.1.5-like + L455F + F456L), Omicron BA.2.86 (B.1.1.529.2.86) and Omicron DeFLiRT (JN.1 + delS31) variants by targeting 21765_21770DelTACATG, 22281_22289DelCTTTACTTG, 28262_28263InsAACA, 22029_22034DelAGTTCA, 28362_28370DelGAGAACGCA, 22121InsGAGCCAGAA, 21633_21641DelTACCCCCTG, G22927T, T22928C and T22930A (L455F and F456L SNVs), ins21610ATGCCGCTGTTT and 21654_21656DelCTT deletions, insertions and SNVs in their genomes. Alpha, Beta, Delta, Omicron BA.1, Omicron BA.2, Omicron Flip, Omicron BA.2.86 and Omicron DeFLiRT markers are mapped to the S gene (residues 69/70, 241/243, 157/158, 214, 25/27, 455/456, 16 and 31 respectively), Gamma insertion is located between the end of ORF8 and the beginning of N gene, and Omicron (B.1.1.529) deletion is mapped to the N gene (residues 31/33). The duplex RTqPCR assay targeting 21765-21770DelTACATG mutation affecting residues HV69/70 has been previously used to estimate the relative proportion of Alpha VOC (Carcereny et al., 2021), and is also suitable to estimate the proportions of Omicron BA.4 and BA.5. All duplex RTqPCR assays targeting signature mutations may be used as a complementary tool to NGS for rapid variant tracking and surveillance in wastewater-based epidemiology.
Development of an ICF Core Set for frailty older people – Study Protocol
Authors: Batalha Diogo , Alvarelhão Joaquim , Almeida Sara , Pinto Joana 
Published: May 2024

Abstract

Frailty is more common as age increases but is not synonymous of ageing. Identifying frail older people should be one of the bases of geriatric care, since this is a complex and important issue associated with aging, with implications for older people and for the functioning of health services. The ICF has the potential to design standardized coding for the various health domains, characterizing the specific functional challenges of individuals, being a first step towards the standardization of the evaluation of results, with several additional advantages. The development of a Core Set allows the creation of practical instruments adjusted to a specific health condition, sufficiently comprehensive and multidisciplinary. It involves formal decision-making and a consensus-seeking process that integrates not only the evidence found in preliminary and already conducted studies but also the creation of a focus group with frail older people, health professionals and experts. We aim to develop an ICF Core Set for frailty and identifying the categories of the ICF most applicable to the weak, according to the frail older people’s perspective and based on international consensus
A mass spectrometry-based workflow to analyze histone post-translational modifications and the associated acid extractome
Authors: Verhelst Sigrid , De Clerck Laura , Willems Sander , Puyvelde Bart Van , Daled Simon , Deforce Dieter , Dhaenens Maarten 
Published: May 2024

Abstract

Worldwide, there is an increasing interest in epigenetics because of its involvement in several diseases. An important epigenetic mechanism is the histone post-translational modifications and the histone code they generate. Mass spectrometry (MS) offers the opportunity to comprehensively characterize the histone code in one single experiment. We developed a workflow that allows starting from a cell pellet to: 1) extract the histones, 2) analyze them via bottom-up proteomics using data-dependent acquisition (DDA) mass spectrometry, and 3) identify and quantify them via our data analysis pipeline. The time required to complete the entire workflow is highly dependent on the number of samples to be analyzed and should be considered as at least 1 week of sample preparation prior to the acquisition, approximately 90 minutes of acquisition time per sample and thereafter one to several weeks of data analysis depending on the complexity of the data.