bluuebunny/crossref_metadata_2025_split huggingface dataset:
Full Dispersion‐Spectrum Inversion of Surface Waves
Authors: Zhang Zhendong , Alkhalifah Tariq , Liu Yike 
Published: June 2024

AbstractNowadays, the most successful applications of full‐waveform inversion (FWI) involve marine seismic data under acoustic approximations. Elastic FWI of land seismic data is still challenging in theory and practice. Here, we propose a full dispersion spectrum inversion method and apply it to seismic data acquired in West Antarctica. Inspired by the conventional surface wave dispersion curve inversion method, we propose to invert the surface wave dispersion spectrum instead of the complicated waveforms. We compare the frequency‐velocity, frequency‐slowness, and frequency‐wavenumber spectra in terms of their ability to resolve dispersion modes and the feasibility of their adjoint updates and conclude that the frequency‐slowness spectrum is the best for our inversion objectives. We test four objective functions, subtraction, zero‐lag crosscorrelation, optimal transport, and the local‐crosscorrelation to quantify the spectrum mismatch and provide the corresponding adjoint source. We then theoretically analyze the convexity of the proposed objective functions and examine their convergence behavior using numerical examples. We also compare the proposed method with the classic FWI method and the traditional surface wave dispersion curve inversion method and discuss the strengths and weaknesses of each method. This technique is employed to evaluate the shallow velocity structures beneath a seismic array stationed in West Antarctica. Our proposed inversion scheme is also useful for more general applications such as imaging the shallow subsurface of the critical zones, like geothermal reservoirs, and CO2 storage sites.
Frictional Properties and Healing Behavior of Tectonic Mélanges: Implications for the Evolution of Subduction Fault Zones
Authors: Chen T.‐W. , Affinito R. , Marone C. , Fisher D. , Smye A. , Hashimoto Y. 
Published: June 2024

AbstractThe frictional velocity dependence and healing behavior of subduction fault zones play key roles in the nucleation of stick‐slip instabilities at convergent margins. Diagenetic to low‐grade metamorphic processes such as pressure solution are proposed to be responsible for the change in frictional properties of fault materials along plate interfaces; pressure solution also likely contributes to the acceleration of healing according to previous studies. Here, we report friction studies for temperatures of 20–100°C and normal stresses from 20 to 125 MPa on samples collected from ancient subduction fault zones, the Lower Mugi and Makimine mélanges of the Cretaceous Shimanto belt. The two mélanges correspond to the updip and downdip limits of the seismogenic zone and include deformation features that indicate lower and higher degrees of pressure solution. Our data show that the Lower Mugi mélange exhibits velocity‐weakening to velocity‐neutral frictional behavior under low normal stress and that the Makimine mélange sample shows velocity‐strengthening behavior under high normal stress. We suggest that mineralogical changes due to diagenesis and metamorphism influence fault slip behavior. We measure frictional healing in slide‐hold‐slide experiments for the Lower Mugi mélange sample and document the role of pressure solution in fault healing. Our results show that frictional healing increases at higher temperatures. The microstructures related to pressure solution found in the post‐experimental gouges support the idea that the enhanced healing is related to pressure solution.
Mesoscale Eddies Influence Coral Reef Environments in the Northwest Gulf of Mexico
Authors: McWhorter J. K. , Roman‐Stork H. L. , Le Hénaff M. , Frenzel H. , Johnston M. A. , Cornec M. , Osborne E. 
Published: June 2024

AbstractCoral reefs globally are experiencing more frequent and severe warming events due to anthropogenic driven climate change. Subtropical reefs experience more seasonal variability than lower latitude reefs making them typically more resilient to climate change. With relatively stable coral cover in comparison to other global coral reefs, Flower Garden Banks National Marine Sanctuary (FGBNMS) in the Gulf of Mexico is a series of 17 reefs and banks located on the continental shelf‐edge containing a variety of shallow (0–30 m) and mesophotic (30–150 m) coral reef habitats. Here, we use satellite data products to associate open ocean Argo float profiles with eddy features over FGBNMS to study the shelf‐edge reef environment spanning nearly two decades (2003–2022). Satellite data show that FGBNMS is frequently influenced (∼15 days/month) by mesoscale eddies. The upper water column variability (0–25 m) is most influenced by the seasonal mixed layer despite eddy interaction. Subsurface seasonal ranges of temperature and salinity are enhanced or suppressed depending on the influence of eddies in relation to the mixed layer depth. Within the mesophotic zone (0–150 m), the largest range of thermal variability between anticyclonic and cyclonic eddies is between 50 and 150 m upwards of 5°C. However, these observed dynamics will likely change as a result of eddy variability associated with projected warming and Loop Current weakening, leading to increased thermal stress in the future.
The Complexity of Moisture Sources Affects the Altitude Effect of Stable Isotopes of Precipitation in Inland Mountainous Regions
Authors: Chen Longhu , Zhu Guofeng , Lin Xinrui , Li Rui , Lu Siyu , Jiao Yinying , Qiu Dongdong , Meng Gaojia , Wang Qinqin 
Published: June 2024

AbstractFrom a global perspective, the stable isotope altitude effect is crucial for understanding climate information. However, the intensity of this effect can be influenced by the source of moisture, particularly in inland mountainous regions where the moisture sources are complex. Different combinations of moisture sources might affect the altitude effect. Focusing on the upper Shiyang River in the northern part of the Qilian Mountains in China, this study calculated the proportion of recycled moisture in precipitation and utilized the HYSPLIT model to determine the source of advective moisture. It explored the characteristics and mechanisms by which moisture sources affect the spatiotemporal variations in precipitation isotope effects within the study area. The findings indicated that: (a) The altitude effect follows a seasonal pattern: winter < autumn < spring < summer, with a reverse effect in winter. (b) As the contribution of recycled moisture to precipitation increases, the altitude effect of stable isotopes weakens, primarily due to the disruptive influence of recycled moisture on this effect. (c) The altitude effect of stable isotopes in precipitation is determined by the direction of the moisture source and its attributes. When the primary source of advective moisture runs perpendicular to the mountain range and the moisture migration speed is slow, the altitude effect is pronounced. Thus, although temperature directly causes the altitude effect, water vapor sources significantly influence it in inland mountainous regions.
Pore‐Scale Modeling of Reactive Transport with Coupled Mineral Dissolution and Precipitation
Authors: Wang Ziyan , Hu Mengsu , Steefel Carl 
Published: June 2024

AbstractWe present a new pore‐scale model for multicomponent advective‐diffusive transport with coupled mineral dissolution and precipitation. Both dissolution and precipitation are captured simultaneously by introducing a phase transformation vector field representing the direction and magnitude of the overall phase change. An effective viscosity model is adopted in simulating fluid flow during mineral dissolution‐precipitation that can accurately capture the velocity field without introducing any empirical parameters. The proposed approach is validated against analytical solutions and interface tracking simulations in simplified structures. After validation, the proposed approach is employed in modeling realistic rocks where mineral dissolution and precipitation are dominant at different locations. We have identified three regimes for mineral dissolution‐precipitation coupling: (a) compact dissolution‐precipitation where dissolution is dominant near the inlet and precipitation is dominant near the outlet, (b) wormhole dissolution with clustered precipitation where dissolution generates wormholes in the main flow paths and precipitation clogs the secondary flow paths, and (c) dissolution dominant where all solid grains are gradually dissolved. In the three regimes, the proposed approach provides reliable porosity‐permeability relationships that cannot be described well by traditional macroscale models. We find that the permeability can increase while the overall porosity decreases when the main flow paths are expanded by dissolution and adjacent pore spaces are clogged by precipitation.
Tidal Control of Equatorial Vertical E × B Drift Under Solar Minimum Conditions
Authors: Liu H.‐L. , Maute A. 
Published: June 2024

AbstractObservations show that equatorial ionospheric vertical drifts during solar minimum differ from the climatology between late afternoon and midnight. By analyzing WACCM‐X simulations, which reproduce this solar cycle dependence, we show that the interplay of the dominant migrating tides, their propagating and in situ forced components, and their solar cycle dependence impact the F‐region wind dynamo. In particular, the amplitude and phase of the propagating migrating semidiurnal tide (SW2) in the F‐region plays a key role. Under solar minimum conditions, the SW2 tide propagate to and beyond the F‐region in the winter hemisphere, and consequently its zonal wind amplitude in the F‐region is much stronger than that under solar maximum conditions. Furthermore, its phase shift leads to a strong eastward wind perturbation near local midnight. This in turn drives a F‐region dynamo with an equatorial upward drift between 18 and 1 hr local times.
Impact of the Polar Vortex on Sub‐Seasonal O/N2 Variability in the Lower Thermosphere Using GOLD and WACCM‐X
Authors: Martinez Benjamin C. , Lu Xian , Pedatella Nicholas M. , Wu Haonan , Oberheide Jens 
Published: June 2024

AbstractWe provide observational evidence that the stability of the stratospheric Polar vortex (PV) is a significant driver of sub‐seasonal variability in the thermosphere during geomagnetically quiet times when the PV is anomalously strong or weak. We find strong positive correlations between the Northern Annular Mode (NAM) index and subseasonal (10–90 days) Global Observations of the Limb and Disk (GOLD) O/N2 perturbations at low to mid‐northern latitudes, with a largest value of +0.55 at ∼30.0°N when anomalously strong or weak (NAM >2.5 or < −2.1) vortex times are considered. Strong agreement for O/N2 variability and O/N2‐NAM correlations is found between GOLD observations and the Whole Atmosphere Community Climate Model with thermosphere‐ionosphere eXtension (WACCM‐X) simulations, which is then used to delineate the global distribution of O/N2‐NAM correlations. We find negative correlations between subseasonal variability in WACCM‐X O/N2 and NAM at high northern and southern latitudes (as large as −0.54 at ∼60.0°S during anomalous vortex times). These correlations suggest that PV driven upwelling at low latitudes is accompanied by corresponding downwelling at high latitudes in the lower thermosphere (∼80–120 km), which is confirmed using calculations of residual mean meridional circulation from WACCM‐X.
Density Stratification and Buoyancy Evolution in Pyroclastic Density Currents
Authors: O’Donnell Sean B. , Johnson Blair A. , Breard Eric C. P. , Buttles James L. , Gardner James E. , Mohrig David , Dufek Josef 
Published: June 2024

AbstractPyroclastic density currents (PDCs) are density‐stratified along their vertical axis, with the near‐bed portion being denser than the upper portion, resulting from particle settling and ambient air entrainment at current margins. Whereas vertical density stratification likely influences mixing, sedimentation, and buoyancy of PDCs, many depth‐averaged models of PDC dynamics assume currents are well‐mixed. We investigated this discrepancy by performing sub‐aqueous laboratory experiments and conducted complementary numerical simulations to interrogate current dynamics at finer scales. Currents with small temperature difference with the ambient fluid become density‐stratified during propagation. The dynamics of such currents resemble two‐phase flows, in which particles move freely and particle concentration becomes stratified, but fluid density remains constant. Currents with large temperature difference with the ambient fluid, however, do not develop density stratification during propagation, due to current dynamics becoming dominated by the fluid phase and the lessening importance of particles. Currents that develop density stratification do not lift off from the bed within the domain of the setup, whereas poorly stratified currents do lift off, forming a rising plume. Strong density stratification within currents inhibits turbulence production, preventing entrained ambient fluid on current edges from mixing into current interiors. Poorly stratified currents are highly turbulent, have vigorous internal mixing, thereby achieving lift‐off. The strongly stratified currents are analogous to PDCs that result from eruption column collapse, maintaining fast velocity, low internal mixing, and high temperature over long distances. The poorly stratified currents are analogous to dilute ash‐cloud surges that develop atop basal avalanches, having short runout distances.
Automatic Estimation of Daily Volcanic Sulfur Dioxide Gas Flux From TROPOMI Satellite Observations: Application to Etna and Piton de la Fournaise
Authors: Grandin Raphaël , Boichu Marie , Mathurin Théo , Pascal Nicolas 
Published: June 2024

AbstractUnderstanding the dynamics of sulfur dioxide (SO2) degassing is of primary importance for tracking temporal variations in volcanic activity. Here we introduce the novel “disk method,” which aims at estimating the daily volcanic SO2 mass flux from satellite images (such as those provided by Sentinel‐5P/TROPOspheric Monitoring Instrument [TROPOMI]). The method calculates a “proto‐flux” using a regression, as a function of distance, of SO2 mass integrated in a series of nested circular domains centered on a volcano. After regression, a single multiplication by plume speed suffices to deduce the SO2 mass flux, without requiring a subsequent regression. This way, a range of plume speed and plume altitude scenarios can be easily explored. Noise level in the image is simultaneously evaluated by the regression, which allows for estimating posterior uncertainties on SO2 flux and improving the level of detection for weak sources in noisy environments. A statistical test is also introduced to automatically detect occurrences of volcanic degassing, lowering the risk of false positives. Application to multi‐year time‐series at Etna (2021) and Piton de la Fournaise (2021–2023) demonstrates (a) a reliable quantification of SO2 emissions across a broad range of degassing styles (from passive degassing to effusive or paroxysmal events), and (b) a reasonable day‐to‐day correlation between SO2 flux and seismic energy. The method is distributed as an open‐source software, and is implemented in an interactive web application within the “Volcano Space Observatory Portal,” facilitating near‐real‐time exploitation of the TROPOMI archive for both volcano monitoring and assessment of volcanic atmospheric hazards.
CCL11 released by GSDMD-mediated macrophage pyroptosis regulates angiogenesis after hindlimb ischemia
Authors: Wang Yiwen , Gao Yang , Shi Huairui , Gao Rifeng , Yang Ji’e , Qu Ya’nan , Hu Shiyu , Zhang Jian , Wang Jingpu , Cao Jiatian , Zhang Feng , Ge Junbo 
Published: June 2024

AbstractPeripheral vascular disease (PVD) is an emerging public health burden with a high rate of disability and mortality. Gasdermin D (GSDMD) has been reported to exert pyroptosis and play a critical role in the pathophysiology of many cardiovascular diseases. We ought to determine the role of GSDMD in the regulation of perfusion recovery after hindlimb ischemia (HLI). Our study revealed that GSDMD-mediated pyroptosis occurred in HLI. GSDMD deletion aggravated perfusion recovery and angiogenesis in vitro and in vivo. However, how GSDMD regulates angiogenesis after ischemic injury remains unclear. We then found that GSDMD-mediated pyroptosis exerted the angiogenic capacity in macrophages rather than endothelial cells after HLI. GSDMD deletion led to a lower level of CCL11 in mice serum. GSDMD knockdown in macrophages downregulated the expression and decreased the releasing level of CCL11. Furthermore, recombinant CCL11 improved endothelial functions and angiogenesis, which was attenuated by CCL11 antibody. Taken together, these results demonstrate that GSDMD promotes angiogenesis by releasing CCL11, thereby improving blood flow perfusion recovery after hindlimb ischemic injury. Therefore, CCL11 may be a novel target for prevention and treatment of vascular ischemic diseases.
Science and applications of 2.5D materials: development, opportunities and challenges
Authors: Ago Hiroki , Solís-Fernández Pablo 
Published: June 2024

Abstract
Research on two-dimensional (2D) materials has made tremendous progress reflecting their unique properties and promising applications. In this perspective, we review the novel concept of “2.5-dimensional (2.5D) materials”, which represent new opportunities to extend the field of materials science beyond 2D materials. This concept consists of controlling van der Waals interactions and using interlayer nanospaces to synthesize new materials and explore their intriguing properties. It also includes combination with other dimensional materials, the fabrication of three-dimensional (3D) architectures of 2D materials, and practical applications in our 3D everyday life. We discuss recent research based on this concept and provide future perspectives.
SuperAnimal pretrained pose estimation models for behavioral analysis
Authors: Ye Shaokai , Filippova Anastasiia , Lauer Jessy , Schneider Steffen , Vidal Maxime , Qiu Tian , Mathis Alexander , Mathis Mackenzie Weygandt 
Published: June 2024

AbstractQuantification of behavior is critical in diverse applications from neuroscience, veterinary medicine to animal conservation. A common key step for behavioral analysis is first extracting relevant keypoints on animals, known as pose estimation. However, reliable inference of poses currently requires domain knowledge and manual labeling effort to build supervised models. We present SuperAnimal, a method to develop unified foundation models that can be used on over 45 species, without additional manual labels. These models show excellent performance across six pose estimation benchmarks. We demonstrate how to fine-tune the models (if needed) on differently labeled data and provide tooling for unsupervised video adaptation to boost performance and decrease jitter across frames. If fine-tuned, SuperAnimal models are 10–100× more data efficient than prior transfer-learning-based approaches. We illustrate the utility of our models in behavioral classification and kinematic analysis. Collectively, we present a data-efficient solution for animal pose estimation.
Comparing the effects of CETP in East Asian and European ancestries: a Mendelian randomization study
Authors: Dunca Diana , Chopade Sandesh , Gordillo-Marañón María , Hingorani Aroon D. , Kuchenbaecker Karoline , Finan Chris , Schmidt Amand F. 
Published: June 2024

AbstractCETP inhibitors are a class of lipid-lowering drugs in development for treatment of coronary heart disease (CHD). Genetic studies in East Asian ancestry have interpreted the lack of CETP signal with low-density lipoprotein cholesterol (LDL-C) and lack of drug target Mendelian randomization (MR) effect on CHD as evidence that CETP inhibitors might not be effective in East Asian participants. Capitalizing on recent increases in sample size of East Asian genetic studies, we conducted a drug target MR analysis, scaled to a standard deviation increase in high-density lipoprotein cholesterol. Despite finding evidence for possible neutral effects of lower CETP levels on LDL-C, systolic blood pressure and pulse pressure in East Asians (interaction p-values < 1.6 × 10−3), effects on cardiovascular outcomes were similarly protective in both ancestry groups. In conclusion, on-target inhibition of CETP is anticipated to decrease cardiovascular disease in individuals of both European and East Asian ancestries.
The methylerythritol phosphate pathway as an oxidative stress sense and response system
Authors: Perez-Gil Jordi , Behrendorff James , Douw Andrew , Vickers Claudia E. 
Published: June 2024

AbstractThe methylerythritol phosphate (MEP) pathway is responsible for biosynthesis of the precursors of isoprenoid compounds in eubacteria and plastids. It is a metabolic alternative to the well-known mevalonate pathway for isoprenoid production found in archaea and eukaryotes. Recently, a role for the MEP pathway in oxidative stress detection, signalling, and response has been identified. This role is executed in part through the unusual cyclic intermediate, methylerythritol cyclodiphosphate (MEcDP). We postulate that this response is triggered through the oxygen sensitivity of the MEP pathway’s terminal iron-sulfur (Fe-S) cluster enzymes. MEcDP is the substrate of IspG, the first Fe-S cluster enzyme in the pathway; it accumulates under oxidative stress conditions and acts as a signalling molecule. It may also act as an antioxidant. Furthermore, evidence is emerging for a broader and highly nuanced role of the MEP pathway in oxidative stress responses, implemented through a complex system of differential regulation and sensitivity at numerous nodes in the pathway. Here, we explore the evidence for such a role (including the contribution of the Fe-S cluster enzymes and different pathway metabolites, especially MEcDP), the evolutionary implications, and the many questions remaining about the behaviour of the MEP pathway in the presence of oxidative stress.
A cocktail nanovaccine targeting key entry glycoproteins elicits high neutralizing antibody levels against EBV infection
Authors: Zhong Ling , Zhang Wanlin , Liu Hong , Zhang Xinyu , Yang Zeyu , Wen Zhenfu , Chen Ling , Chen Haolin , Luo Yanran , Chen Yanhong , Feng Qisheng , Zeng Mu-Sheng , Zhao Qinjian , Liu Lixin , Krummenacher Claude , Zeng Yi-Xin , Chen Yongming , Xu Miao , Zhang Xiao 
Published: June 2024

AbstractEpstein-Barr virus (EBV) infects more than 95% of adults worldwide and is closely associated with various malignancies. Considering the complex life cycle of EBV, developing vaccines targeting key entry glycoproteins to elicit robust and durable adaptive immune responses may provide better protection. EBV gHgL-, gB- and gp42-specific antibodies in healthy EBV carriers contributed to sera neutralizing abilities in vitro, indicating that they are potential antigen candidates. To enhance the immunogenicity of these antigens, we formulate three nanovaccines by co-delivering molecular adjuvants (CpG and MPLA) and antigens (gHgL, gB or gp42). These nanovaccines induce robust humoral and cellular responses through efficient activation of dendritic cells and germinal center response. Importantly, these nanovaccines generate high levels of neutralizing antibodies recognizing vulnerable sites of all three antigens. IgGs induced by a cocktail vaccine containing three nanovaccines confer superior protection from lethal EBV challenge in female humanized mice compared to IgG elicited by individual NP-gHgL, NP-gB and NP-gp42. Importantly, serum antibodies elicited by cocktail nanovaccine immunization confer durable protection against EBV-associated lymphoma. Overall, the cocktail nanovaccine shows robust immunogenicity and is a promising candidate for further clinical trials.