bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Effect of Exposure to Neighborhood Violence on Glucocorticoid Receptor Signaling in Lung Tumors
Authors: Heath Hannah , Yoo Jin Y. , Akter Sabrina , Jain Atharva , Sharma Vani , McGee Hannah , Soliman Aiman , Mahmoud Abeer M. , Matthews Alicia K. , Winn Robert A. , Madak-Erdogan Zeynep , Kim Sage J. 
Published: June 2024

Abstract

Despite lower rates and intensity of smoking, Black men experience a higher incidence of lung cancer compared to white men. The racial disparity in lung cancer is particularly pronounced in Chicago, a highly segregated urban city. Neighborhood conditions, particularly social stress, may play a role in lung tumorigenesis. Preliminary studies indicate that Black men residing in neighborhoods with higher rates of violent crime have significantly higher levels of hair cortisol, an indicator of stress response. To examine the relationship between social stress exposure and gene expression in lung tumors, we investigated glucocorticoid receptor (GR) binding in 15 lung tumor samples in relation to GR target gene expression levels and zip code level residential violent crime rates. Spatial transcriptomics and a version of ChIP sequencing known as CUT&RUN were used. Heatmap of genes, pathway analysis, and motif analysis were conducted at the statistical significance of P &lt; 0.05. GR recruitment to chromatin was correlated with zip code level residential violent crime rate and overall GR binding increased with higher violent crime rates. Our findings suggest that exposure to residential violent crime may influence tumor biology via reprogramming GR recruitment. Prioritizing lung cancer screening in neighborhoods with increased social stress, such as high levels of violent crime, may reduce racial disparities in lung cancer.

Significance:
Exposure to neighborhood violent crime is correlated with glucocorticoid signaling and lung tumor gene expression changes associated with increased tumor aggressiveness, suggesting social conditions have downstream biophysical consequences that contribute to lung cancer disparities.
Polycentric Climate Governance: The State, Local Action, Democratic Preferences, and Power—Emerging Insights and a Research Agenda
Authors: Kellner Elke , Petrovics Daniel , Huitema Dave 
Published: June 2024

Abstract
In recent years, climate governance has shifted from the global, multilateral regime to voluntary initiatives from multiple directions. Scholars frequently use a polycentric governance lens to study the complex and multijurisdictional reality. The polycentric perspective helps to grasp the new reality at a general level, but it is lacking in specificity. To fill this research gap, this article attempts to enhance the analytical power of the polycentric governance perspective by exploring four issues: the role of the state, diffusion of local action, integration of local democratic preferences, and the role of power. These issues are discussed by doing a systematic literature review of empirical polycentric governance literature regarding climate change mitigation. The results show the importance of states at the national level and provide insights into how local initiatives share and transfer knowledge, get supported by transnational networks, and secure compliance with local democratic preferences. The literature provides less insight into the role of power. The article concludes by developing research agendas for further cumulation of knowledge and to strengthen climate action at all levels.
Predicting an individual’s functional connectivity from their structural connectome: Evaluation of evidence, recommendations, and future prospects
Authors: Zalesky Andrew , Sarwar Tabinda , Tian Ye , Liu Yuanzhe , Yeo B. T. Thomas , Ramamohanarao Kotagiri 
Published: June 2024

Abstract
Several recent studies have optimized deep neural networks to learn high-dimensional relationships linking structural and functional connectivity across the human connectome. However, the extent to which these models recapitulate individual-specific characteristics of resting-state functional brain networks remains unclear. A core concern relates to whether current individual predictions outperform simple benchmarks such as group averages and null conditions. Here, we consider two measures to statistically evaluate whether functional connectivity predictions capture individual effects. We revisit our previously published functional connectivity predictions for 1,000 healthy adults and provide multiple lines of evidence supporting that our predictions successfully capture subtle individual-specific variation in connectivity. While predicted individual effects are statistically significant and outperform several benchmarks, we find that effect sizes are small (i.e., 8%–11% improvement relative to group-average benchmarks). As such, initial expectations about individual prediction performance expressed by us and others may require moderation. We conclude that individual predictions can significantly outperform appropriate benchmark conditions and we provide several recommendations for future studies in this area. Future studies should statistically assess the individual prediction performance of their models using one of the measures and benchmarks provided here.
Exploring memory-related network via dorsal hippocampus suppression
Authors: Han Xu , Cramer Samuel R. , Chan Dennis C. Y. , Zhang Nanyin 
Published: June 2024

Abstract
Memory is a complex brain process that requires coordinated activities in a large-scale brain network. However, the relationship between coordinated brain network activities and memory-related behavior is not well understood. In this study, we investigated this issue by suppressing the activity in the dorsal hippocampus (dHP) using chemogenetics and measuring the corresponding changes in brain-wide resting-state functional connectivity (RSFC) and memory behavior in awake rats. We identified an extended brain network contributing to the performance in a spatial memory related task. Our results were cross-validated using two different chemogenetic actuators, clozapine (CLZ) and clozapine-N-oxide (CNO). This study provides a brain network interpretation of memory performance, indicating that memory is associated with coordinated brain-wide neural activities.
Factors Associated With Loss to Follow Up After Temporal Bone Fracture
Authors: Patel Aneesh A. , Weber Peter C. 
Published: June 2024

Introduction: Inpatient and outpatient evaluation is important for management of temporal bone trauma due to the possible otologic complications that can result. However, there is limited literature on follow up rates following temporal bone fracture. This study aimed to determine the proportion of patients lost to follow up after sustaining temporal bone fractures and identify factors associated with loss to follow up. Methods: Retrospective review of adult patients who sustained temporal bone fractures at a level I trauma center from January 1, 2019 to January 1, 2024 was completed (IRB H-44161). The primary outcome included prevalence of patient loss to follow up. Secondary variables included initial radiographic and exam findings, otologic complications, and demographic characteristics. Patients who were seen in follow up and lost to follow up were compared, and odds of loss to follow up was calculated. Results: Sixty-nine patients met inclusion criteria for this study, of which 30 patients (43.5%) were lost to follow up. Patients who were White had a significantly lower odds of loss to follow up than those who were not White (OR = 0.2506 (95% CI: 0.0706, 0.8067, P = .0024). While need for acute management was not significantly different between the groups, a significantly lower proportion of patients who were intubated on presentation ( P = .0091), had abnormal otoscopic exam ( P = .0211), and had otologic complications ( P = .0056) were lost to follow up. Conclusion: Almost half of patients who sustained temporal bone fractures, including a significantly higher odds of minority race/ethnicity patients, were lost to follow up.
Clinical and Radiological Outcomes of Medial Meniscal Allograft Transplantation Combined With Realignment Surgery
Authors: Lee Dhong Won , Kang Sung Jin , Kim Rak Jun , Cho Seung Ik , Moon Sung Gyu , Yang Sang Jin , Kim Jin Goo 
Published: June 2024

Background: The outcomes of medial meniscal allograft transplantation (MMAT) combined with high tibial osteotomy (HTO) compared with isolated MMAT remain unclear. Purpose: To compare the clinical and radiological results of MMAT combined with HTO and isolated MMAT. Study Design: Cohort study; Level of evidence, 3. Methods: This retrospective study included 42 consecutive patients, who were divided into group M (isolated MMAT; n = 22) and group H (MMAT combined with HTO with a varus angle >3°; n = 20). Group differences in subjective knee scores, isokinetic muscle strength test, and radiological outcomes (Kellgren-Lawrence grade, mechanical axis, graft extrusion, graft status, and articular cartilage loss) were compared. Results: The mean follow-up period was 29.2 ± 4.9 months and 27.4 ± 5.3 months for groups M and H, respectively. The Lysholm score improved from 55.4 ± 9.5 to 81.3 ± 9.7 and from 52.6 ± 8.9 to 84.2 ± 10.2 in groups M and H, respectively (both P < .001). The International Knee Documentation Committee subjective score improved from 51.4 ± 10.3 to 79.6 ± 9.4 and from 49.3 ± 11.4 to 81.4 ± 8.3 in groups M and H, respectively (both P < .001). Both groups showed no significant differences in subjective knee scores and isokinetic extensor strength at the final follow-up. The rate of preoperative and postoperative high International Cartilage Regeneration & Joint Preservation Society grade (≥3) did not differ between the 2 groups. Group M showed greater coronal graft extrusion than did group H (3.3 ± 0.7 mm vs 2.7 ± 0.8 mm; P = .014); the rate of pathologic graft extrusion (≥3 mm) was not higher in group M (40.9%) than in group H (20%) with the number of patients available ( P = .143). Both groups showed no significant difference in the graft status. Graft tears were observed in 2 patients (9%) in group M and 1 patient (5%) in group H ( P = .607). Conclusion: Clinical scores significantly improved after isolated MMAT and MMAT combined with HTO compared with preoperative values, and their short-term outcomes were similar. Postoperative graft extrusion was greater in patients who underwent isolated MMAT, implying that active correction of varus alignment during MMAT may help in intra-articular biomechanics.
Barriers Experienced by Community-Dwelling Older Adults Navigating Formal Care: Evidence From an Australian Population-Based National Survey
Authors: Xie Yuchen , Sinclair Craig , Hamilton Myra , Peisah Carmelle , Temple Jeromey , Anstey Kaarin J. 
Published: June 2024

Objectives This study aims to identify the relationship between psychosocial factors and unmet needs among community-dwelling older adults who have received or who expect to receive formal home-based aged care services. Methods A subsample of the national Survey of Disability, Ageing and Carers was used to examine the prevalence of having any unmet needs among older adults navigating care. We also examined associations between older adults’ psychosocial factors and their unmet needs using logistic regression. Results Regression analyses highlighted that perceived social isolation (OR = 1.62, 95% CI: 1.30–2.01), high/very high psychological distress (OR = 2.11, 95% CI: 1.52–2.93), and occasional assistance from informal support (OR = 1.92, 95% CI: 1.22–3.05) were associated with increased odds of having unmet needs, after adjusting for other covariates. Discussion Our study suggests that older adults facing psychosocial difficulties or lacking informal support are more likely to encounter barriers in accessing formal care. Future policy should address the psychosocial needs and support networks of older adults.
Composite membrane containing phytic acid-functionalized metal-organic frameworks for enhanced ion selectivity
Authors: Zhang Yuxia , Liu Haojie , Liu Min , Zhang Yitian , Ding Chenjing , Gong Yunyun 
Published: June 2024

The application of sulfonated poly (ether ether ketone) (SPEEK) membrane in vanadium redox flow batteries (VRFBs) is hindered by the trade-off between proton conductivity and ion selectivity. To optimize its performance, the metal-organic frameworks loaded with phytic acid (PA-UiO-66-NH2) are introduced into the SPEEK matrix to construct a proton-selective transport channel. Better proton conductivity and ion selectivity are achieved in composite membranes due to the unique porous structure and chemical characteristics of PA-UiO-66-NH2 fillers. When the PA-UiO-66-NH2 content is at 2 wt%, the S/PA-UiO-66-NH2-2 membrane exhibits higher proton conductivity (35.3 mS cm−1) and ion selectivity (41.0 × 103 S min cm−3) compared to other composite membranes, pristine SPEEK and commercial Nafion 212 membranes. As a result, the S/PA-UiO-66-NH2-2 membrane shows excellent energy efficiencies (88.1%-74.0%) at current densities ranging from 60 to 180 mA cm−2. The cell efficiencies maintain stability during the 300 times charge-discharge cycle, proving the outstanding stability and durability of the S/PA-UiO-66-NH2-2 membrane in a strong acidic and oxidizing environment. These results suggest that the combination of phytic acid and metal-organic framework can effectively improve the performance of the membranes, and it also can be further utilized to solve other challenges in the membrane separation field.
Brain and cervical spinal cord MRI correlates of sensorimotor impairment in patients with multiple sclerosis
Authors: Morozumi Tetsu , Preziosa Paolo , Meani Alessandro , Pessina Giorgia , Pagani Elisabetta , Azzimonti Matteo , Filippi Massimo , Rocca Maria A 
Published: June 2024

Background: Cervical spinal cord (cSC) lesions and atrophy contribute to disability in multiple sclerosis (MS), but associations with specific sensorimotor dysfunction require further exploration. Objective: To investigate the associations of brain and cSC magnetic resonance imaging (MRI) measures with sensorimotor impairment in MS. Methods: One hundred fifty-one MS patients and 69 healthy controls underwent 3T MRI and clinical assessments including Expanded Disability Status Scale (EDSS), 9-hole peg test (9-HPT), finger tapping test (FTT), timed 25-foot walk test (T25FWT), and vibration detection threshold (VDT). Random forest ranked brain (T2-hyperintense lesion volume (T2-LV) and normalized deep gray matter (GM), cortical and white matter (WM) volumes) and cSC (T2-LV and total, GM, and WM cross-sectional areas (CSAs) at C2/C3 level) MRI measures relevance in explaining EDSS milestones (EDSS ⩾3.0, ⩾4.0, and ⩾6.0), VDT, pyramidal and sensory functional systems (P-FS and S-FS ⩾2), and motor tests impairment. Results: Various combinations of brain and cSC MRI measures explained EDSS milestones (area under the curve (AUC) =0.879–0.900), VDT ( R2 = 0.194), and impaired P-FS (AUC = 0.820), S-FS (AUC = 0.795), 9-HPT (AUC = 0.793), FTT (AUC = 0.740), and T25FWT (AUC = 0.825). cSC GM CSA was the most informative feature for all outcomes, except 9-HPT. Conclusion: cSC MRI measures, especially GM CSA, explain EDSS and sensorimotor dysfunction better than brain measures in MS.
Review of Mixed Arterial Venous Leg Ulcers (MAVLU) Disease in Contemporary Practice
Authors: Alagha Mohammed , Alfatih Ahmmad , Westby Daniel , Walsh Stewart R. 
Published: June 2024

Background Mixed Arterial and Venous Leg Ulcers (MAVLU) are challenging. Clinical evidence specific to MAVLU management is scarce. We evaluated our recent experience with MAVLU patients and reviewed current data regarding MAVLU epidemiology, aetiology, diagnostic assessment and management options. Methods A prospective leg ulcer database was retrospectively interrogated to determine the prevalence and clinical outcome of MAVLU over 2-year period (2021-2022). The literature was reviewed to determine if optimal treatment strategies. Results 307 patients attended the ulcer clinic over a 2-year period. Most were venous leg ulcers (71%), 24% were arterial and 5% were MAVLU. The highest healing rate was in MAVLU (93%), followed by (74%) and (41%), in arterial and venous leg ulcer groups, respectively. Conclusion Evidence-based guidelines for MAVLU remain lacking. Well-developed randomised controlled trials are warranted to guide current clinical practice.
Comparison of Postoperative Pain and Surgical Outcomes Between Three Types of Modified Muscle-Sparing Laminoplasty and Conventional Laminoplasty for Multilevel Degenerative Cervical Myelopathy
Authors: Wang Ben , Qu Ruomu , Liu Zexiang , Zhao Nan , Pan Shengfa , Chen Xin , Zhao Yanbin , Dang Lei , Zhou Hua , Wei Feng , Sun Yu , Zhou Feifei , Jiang Liang 
Published: June 2024

Study Design Retrospective cohort study. Objective This study aimed to compare postoperative pain and surgical outcomes of open-door laminoplasty (LP) and three types of muscle-sparing laminoplasties, namely unilateral muscle-preservation laminoplasty (UL), spinous process splitting double-door laminoplasty (DL) and intermuscular “raising roof” laminoplasty (RL) for multilevel degenerative cervical myelopathy (MDCM). Methods Consecutive MDCM patients underwent LP or modified laminoplasties (UL, DL, RL) in 2022 were enrolled. Patients’ preoperative baseline data and surgical characteristics were collected. Postoperative transient pain (TP), the axial pain and Japanese Orthopedic Association (JOA) score and neck disability index (NDI) at 6-month and 12-month follow-up were documented. Results A total of 154 MDCM patients were included and a 12-month follow-up was completed for 148 patients (LP: 36, UL:39, DL: 37, RL:36). No significant difference was observed in the baseline data. Four groups presented favorable and comparable surgical outcome. The RL group reported significantly the least severe TP on the first three days following surgery. However, no significant difference was found in the axial pain and axial symptoms at both follow-ups. After regression analysis, RL group exhibited significantly better efficacy in alleviating Day-1 TP ( P = 0.047) and 6-month axial pain ( P = 0.040). However, this superiority was not observed at 12-month follow-up. Conclusion All the three muscle-sparing laminoplasty procedures showed similar short-term surgical outcomes compared to LP. The RL procedure demonstrated superiority in alleviating TP and 6-month axial pain compared to LP. The RL and DL groups showed less C5 palsy compared to LP.
Effect of coating time on the formation of coating layer and degradation behavior of hydroxyapatite coated ZK60 alloy
Authors: Van Hai Le , Nhu Ngoc Do , Mai Khanh Pham , Van Tuan Le , Nhat Dinh Vu , Viet Nam Nguyen 
Published: June 2024

Objectives: This study aims to investigate the effect of coating time on the formation of hydroxyapatite (HA) coating layer on ZK60 substrate and understand the biodegradation behavior of the coated alloy for biodegradable implant applications. Methods: Biodegradable ZK60 alloy was coated by HA layer for different times of 0.5, 1, 2, and 4 h by chemical conversion method. After coating, all the coated specimens were used for immersion test in Hanks’ solution to understand the effect of coating time on the degradation behavior of the alloy. The degradation rate of the coated alloy was evaluated by Mg2+ ion quantification and pH change during immersion test. The microstructure of the coating layer was examined by scanning electron microscope (SEM) equipped with an energy-dispersive X-ray spectroscopy (EDS) before and after immersion to understand the degradation behavior of the coated alloy. Results: HA coating layers were formed successfully on surface of ZK60 specimens after 0.5, 1, 2, and 4 h with different microstructure. Optimal coating quality was observed at 1 or 2 h, characterized by well-formed and uniform HA layers. However, extending the coating duration to 4 h led to the formation of cracks within the HA layer, accompanied by Mg(OH)2. Specimens coated for 1 and 2 h exhibited the lowest degradation rates, while specimens coated for 0.5 and 4 h showed the highest degradation rates. Furthermore, analysis of degradation products revealed the predominance of calcium phosphates formed on the surface of specimens coated for 1 and 2 h. Conversely, specimens coated for 0.5 and 4 h exhibited Mg(OH)2 as the primary degradation product, suggesting a less effective corrosion barrier under these conditions. Conclusion: The HA layer formed after 2 h demonstrated as the most effective coating layer for enhancing the corrosion resistance of the ZK60 alloy for biomedical applications.
Developing and validating a scale to measure the perceptions of safety, usability and acceptability of microarray patches for vaccination: a study protocol
Authors: Berger Matthew N. , Davies Cristyn , Mathieu Erin , Shaban Ramon Z. , Bag Shopna , Skinner S. Rachel 
Published: June 2024

Background: Vaccination is a fundamental tenet of public and population health. Several barriers to vaccine uptake exist, exacerbated post-COVID-19, including misconceptions about vaccine efficacy and safety, vaccine hesitancy, vaccine inequity, costs, religious beliefs, and insufficient education and guidance for healthcare professionals. Vaccine uptake may be aided using microarray patches (MAPs) due to reduced pain, no hypodermic needle, enhanced thermostability, and potential for self and lay administration. Objectives: This protocol outlines the development of a scale that aims to accurately measure the perceived safety, usability, and acceptability of MAPs for vaccination among laypeople, MAP recipients, clinicians, and parents or guardians of children. Methods and analysis: This study will follow three phases of scale development and validation, including (1) item development, (2) scale development, and (3) scale evaluation. Inductive (interviews) and deductive methods (literature searches) will be used to develop scale items, which experts from target populations will assess through an online survey. Cognitive interviews will be conducted to observe their processes of answering the draft survey. Thematic analysis will be conducted to analyse qualitative data. Lastly, four surveys will be administered online to our target populations over two time points to determine their repeatability. Exploratory and confirmatory factor analyses, Cronbach’s alpha, and construct validity will be performed. Ethics: This study was approved by Metro South Health (HREC/2021/QMS/81653) and Western Sydney Local Health District (2023/ETH00705) Human Research Ethics Committees. Discussion: The scale will support a standardised approach to assessing the social and behavioural aspects of MAP vaccines, enabling comparison of outcomes across studies. Once validated, this scale will assist vaccination programmes in developing effective strategies for integrating MAPs and overcoming barriers to vaccination. This includes improving vaccine equity and accessibility, especially in lower- and middle-income countries and rural or remote locations.