bluuebunny/crossref_metadata_2025_split huggingface dataset:
ChemInform Abstract: Synthesis of Biologically Active Glycopeptides
Authors: Koeller Kathryn M. , Wong Chi‐Huey 
Published: June 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Eplerenone: Antihypertensive Treatment of Heart Failure Aldosterone Antagonist
Authors: Rabasseda X. , Silvestre J. , Castaner J. 
Published: June 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Syntheses and Structures of Novel Molecular Organotin Chalcogenides
Authors: Zobel Bernhard , Schurmann Markus , Ludwig Ralf , Jurkschat Klaus , Dakternieks Dainis , Duthie Andrew 
Published: June 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Syntheses, Dynamic Stereochemistry, and Unusual Reactivity of Intramolecularly Coordinated Organotin Fluorides
Authors: Pieper Nicole , Ludwig Ralf , Schurmann Markus , Jurkschat Klaus , Biesemans Monique , Verbruggen Ingrid , Willem Rudolph 
Published: June 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Ferrocene‐ and Silicon‐Containing Organotin(IV) Halides as Lewis Acidic Hosts for Anions
Authors: Altmann Reiner , Fontani Marco , Gausset Olivier , Jurkschat Klaus , Schurmann Markus , Zanello Piero 
Published: June 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Stannasiloxanes: Syntheses, Structures, and Surprises
Authors: Jurkschat Klaus 
Published: June 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis of Heterocyclic Amines by Reductive Amination of Aldehydes and Ketones
Authors: Klyuyev M. V. , Abdullayev M. G. 
Published: June 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Bioorganogermanium Chemistry: Studies on C/Si/Ge Bioisosterism
Authors: Tacke R. , Heinrich T. , Kornek T. , Merget M. , Wagner A. , Gross J. , Keim C. , Lambrecht G. , Mutschler E. , Beckers T. , et al. et al. 
Published: June 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Coronatine: Chemistry and Biological Activities
Authors: Ichihara Akitami , Toshima Hiroaki 
Published: June 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Cyanoacetamides and Their Thio‐ and Selenocarbonyl Analogues as Promising Reagents for Fine Organic Synthesis
Authors: Litvinov V. P. 
Published: June 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Cyclin‐Dependent Kinase Inhibitors: Useful Targets in Cell Cycle Regulation
Authors: Sielecki Thais M. , Boylan John F. , Benfield Pamela A. , Trainor George L. 
Published: June 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Structure—Reactivity Cross Correlations in Nucleophilic Substitution: Isoparametricity and Transition‐State Structure
Authors: Shpan'ko I. V. 
Published: June 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Radical Pairs in Redox Reactions Involving Sterically Hindered Quinones and Phenols
Authors: Prokof'ev A. I. 
Published: June 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Nanoshocks in Molecular Materials
Authors: Dlott Dana D. 
Published: June 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Fluorinated Butanolides and Butenolides. Part 5. Synthesis and Nucleophilic Reactions of 3‐Chloro‐2‐fluoro‐2‐buten‐4‐olide (IX) as Tetronic Acid Analogue. Conjugate Addition of Hard Nucleophiles and Vinylic Halogen Displacement with Soft Phosphorus Nucleophiles.
Authors: Paleta Oldrich , Volkov Andrei , Hetflejs Jiri 
Published: June 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis and X‐Ray Structure of Stable 2H‐Isoindoles.
Authors: Murashima Takashi , Tamai Ryuij , Nishi Keiji , Nomura Kentaroh , Fujita Ken‐ichi , Uno Hidemitsu , Ono Noboru 
Published: June 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Two New Meliacarpinins from the Roots of Melia azedarach.
Authors: Fukuyama Yoshiyasu , Ogawa Mari , Takahashi Hironobu , Minami Hiroyuki 
Published: June 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis of Alkenes by the Reaction of Magnesium Sulfone Derivatives with Arylsulfonylhydrazones of Aldehydes.
Authors: Kurek‐Tyrlik Alicja , Marczak Stanislaw , Michalak Karol , Wicha Jerzy 
Published: June 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis and Pharmacology of New Enantiopure Δ3‐4‐Arylkainoids.
Authors: Rondeau Dany , Gill Patrice , Chan Monique , Curry Kenneth , Lubell William D. 
Published: June 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Beurteilung fester Adsorbenzien auf der Basis der Adsorptionsgleichgewichte für energetische Anwendungen in offenen Systemen
Authors: Hauer A. 
Published: June 2010

AbstractUm offene Adsorptionssysteme in energetischen Anwendungen ökologisch und ökonomisch sinnvoll einsetzen zu können müssen geeignete Adsorbenzien identifiziert werden. Als energetischen Anwendungen kommen Heizen, Kühlen und Speichern thermischer Energie (TES) in Betracht. Ein geeignetes Adsorbens muss in der Lage sein, die geforderte Temperatur zum Heizen bzw. Kühlen bereit zu stellen und es muss über eine ausreichend hohe Speicherkapazität verfügen. Es wurde eine einfache Methode entwickelt, um den Zusammenhang zwischen diesen Anforderungen und den Materialeigenschaften herzustellen. Die entscheidende Eigenschaft der Adsorbenzien ist die differentielle Adsorptionsenthalpie des jeweiligen Stoffpaares [14], die aus den Adsorptionsgleichgewichten der Adsorbenzien mit Wasserdampf ermittelt wurde. Daraus können die Durchbruchskurven (Temperatur), der mögliche Temperaturhub (bzw. die Luftentfeuchtung) der Luft bei der Adsorption, das Wärmeverhältnis (beim Einsatz als Wärmepumpe) und die Speicherkapazität abgeleitet werden und die Adsorbenzien beurteilt werden.
Marginal zone lymphomas
Authors: Mazloom Ali , Medeiros L. Jeffrey , McLaughlin Peter W. , Reed Valerie , Cabanillas Fernando F. , Fayad Luis E. , Pro Barbara , Gonzalez Graciela , Iyengar Puneeth , Urbauer Diana L. , Dabaja Bouthaina S. 
Published: June 2010

AbstractBACKGROUND:A retrospective review and analysis of 275 patients with marginal zone lymphoma (MZL) was performed to determine prognostic factors. An effort was also made to establish a specific prognostic score for patients with extranodal MZL.METHODS:Patients were divided into 3 groups according to the type of MZL: extranodal, nodal, and splenic. Factors analyzed included age; gender; presence of B symptoms; Zubrod performance score; clinical stage; serum β2‐microglobulin, lactate dehydrogenase, albumin, and hemoglobin levels; and presence of autoimmune disorder.RESULTS:The 5‐year overall survival rates of patients with extranodal, nodal, and splenic MZL were 87%, 89%, and 93%, respectively (P = .95). On multivariate analysis, splenic MZL patients had the best prognosis (hazard ratio, 0.18; P = .018). An elevated serum β2‐microglobulin level (P = .010), B symptoms (P = .021), and male gender (P = .036) were found to be correlated with decreased recurrence‐free survival (RFS) on multivariate analysis. Using these 3 variables, a 3‐tier prognostic scoring system was created for patients with extranodal MZL: low‐risk with no adverse factors, intermediate‐risk with 1 adverse factor, and high‐risk with ≥2 adverse factors. The 5‐year RFS rates for the low‐risk, intermediate‐risk, and high‐risk groups were 80%, 71%, and 44%, respectively (P = .01).CONCLUSIONS:Patients with extranodal and nodal MZL have a similar prognosis, whereas patients with splenic MZL have a better prognosis despite the increased prevalence of negative prognostic indicators. With the use of 3 readily available factors, a prognostic scoring system was identified for patients with extranodal MZL. Cancer 2010. © 2010 American Cancer Society.
Breast cancer subtypes and response to systemic treatment after whole‐brain radiotherapy in patients with brain metastases
Authors: Niwińska Anna , Murawska Magdalena , Pogoda Katarzyna 
Published: June 2010

AbstractBACKGROUND:The aim of this study was to assess the role of systemic treatment after whole‐brain radiotherapy (WBRT) in immunohistochemically defined biological subsets of breast cancer patients with brain metastases.METHODS:The group of 420 consecutive breast cancer patients with brain metastases treated at the same institution between the years of 2003 to 2009 was analyzed. Patients were divided into 4 immunohistochemically biological subsets, based on the levels of estrogen, progesterone, and human epidermal growth factor receptor 2 (HER2) receptors, and labeled as luminal A, luminal B, HER2, and triple‐negative. Survival from brain metastases with and without systemic treatment after WBRT was calculated in 4 subsets.RESULTS:In the entire group, the median survival from brain metastases in patients without and with systemic treatment after WBRT was 3 and 10 months, respectively (P < .0001). In the triple‐negative subset, the median survival from brain metastases with and without systemic treatment was 4 and 3 months (P = .16), and in the luminal A subset, it was 12 and 3 months, respectively (P = .003). In the luminal B subset, the median survival without further treatment, after chemotherapy and/or hormonal therapy, and after chemotherapy and/or hormonal therapy with targeted therapy was 2 months, 9 months, and 15 months, respectively (P < .0001). In the HER2 subset, the median survival was 4 months, 6 months, and 13 months, respectively (P < .0001). No significant response to systemic treatment was noted in the triple‐negative breast cancer population.CONCLUSIONS:Systemic therapy, ordered after WBRT, appears to improve survival in patients with the luminal A, luminal B, and HER2 breast cancer subtypes. Targeted therapy was found to have an additional positive impact on survival. In patients with triple‐negative breast cancer, the role of systemic treatment after WBRT appears to be less clear, and therefore this issue requires further investigation. Cancer 2010. © 2010 American Cancer Society.
Quantification of oligodendrocyte progenitor cells in human and cat optic nerve: Implications for endogenous repair in multiple sclerosis
Authors: Jennings Alison , Carroll William 
Published: June 2010

AbstractIn multiple sclerosis (MS), one strategy to reduce disability is enhancement of endogenous repair by remyelinating oligodendrocytes derived from oligodendrocyte progenitor cells (OP). An important prerequisite is determining the abundance of OP relative to oligodendrocytes in normal human central nervous system (CNS), which, in turn, requires reliable OP identification. To achieve this, cat and human optic nerves (ON) were subjected to varied preparation protocols, and the resultant neuroglial staining profiles correlated to generate an antigenic phenotype for OP applicable to human autopsy specimens. OP, interchangeably called NG2cells due to universal NG2 expression, were shown to comprise a separate class of neuroglial cells, related to oligodendrocytes by expression of the oligodendrocyte lineage transcription factors, Olig1 and Olig2. Despite their morphological complexity, including contact with axons and other neuroglia, NG2cells all appear capable of responding as OP to counter local oligodendrocyte loss. However, quantification revealed that NG2cells comprised less than 5% of the neuroglia and had a ratio to oligodendrocytes of about 1:10, not only in human and cat ON but also in white and gray‐matter regions of cat spinal cord. The finding that NG2cells are not abundant, particularly relative to oligodendrocytes, may have implications for efforts to enhance endogenous repair in MS. © 2010 Wiley‐Liss, Inc.
Comparative gene expression profiling of olfactory ensheathing cells from olfactory bulb and olfactory mucosa
Authors: Guérout Nicolas , Derambure Céline , Drouot Laurent , Bon‐Mardion Nicolas , Duclos Célia , Boyer Olivier , Marie Jean‐Paul 
Published: June 2010

AbstractOlfactory ensheathing cells (OEC) have the ability to promote regeneration in the nervous system. Hence, they hold promise for cell therapy. Most of the experimental studies have investigated the role of OECs taken from olfactory bulb (OB). However, for a clinical human application, olfactory mucosa (OM) seems to be the only acceptable source for OECs. Many studies have compared the distinct ability of OECs from OB and OM to improve functional nerve regeneration after lesion of the nervous system. Nevertheless, the two populations of OECs may differ in several points, which might affect all fate after transplantation in vivo. We report here the first study which compares gene expression profiling between these two populations of OECs. It appears that OB‐OECs and OM‐OECs display distinct gene expression pattern, which suggest that they may be implicated in different physiological processes. Notably, OM‐OECs overexpress genes characteristic of wound healing and regulation of extra cellular matrix. In contrast, OB‐OECs gene profile suggests a prominent role in nervous system development. Hence, OB‐OECs and OM‐OECs fundamentally differ in their gene expression pattern, which may represent a crucial point for future clinical application. © 2010 Wiley‐Liss, Inc.
p75NTR induces apoptosis in medulloblastoma cells
Authors: Küchler Jan , Hartmann Wolfgang , Waha Anke , Koch Arend , Endl Elmar , Wurst Peter , Kindler Dagmar , Mikeska Thomas , Waha Andreas , Goodyer Cynthia G. , Büttner Reinhard , Schilling Karl , Pietsch Torsten 
Published: June 2010

AbstractThe classic medulloblastoma (CMB) and the desmoplastic medulloblastoma (DMB) subtypes represent the major medulloblastoma variants. In contrast to CMB, DMB display high levels of the low‐affinity nerve growth factor receptor p75NTR. Given the reports of a better clinical course of DMB, we hypothesized that p75NTR might act as a tumor suppressor in medulloblastomas. In a large set of medulloblastomas, p75NTR was screened for mutations, and its mRNA expression and the DNA methylation status of its 5′‐region were assessed. p75NTR immunostainings were performed in wild‐type murine cerebella and medulloblastomas arising in patched heterozygous mice, and murine cerebellar granule cell precursors (GCP) were analyzed in vitro. Medulloblastoma cells engineered to express p75NTR were characterized flow cytometrically and morphologically. One CMB displayed a mutation of the p75NTR coding sequence. p75NTR mRNA levels clearly delineated DMB and CMB; however, CpG island hypermethylation was excluded as the cause of low p75NTR expression in CMB. Sonic Hedgehog‐treated GCP showed elevated p75NTR expression, and strong expression of p75NTR was detected in the external granule cell layer of wild‐type mice and in murine ptc± medulloblastomas. CMB cells overexpressing p75NTR displayed a significant increase in apoptosis. In summary, our data link activated Hedgehog signaling in DMB with p75NTR expression and characterize p75NTR as a biologically relevant inductor of apoptosis in MB.
The ARF tumor suppressor: Structure, functions and status in cancer
Authors: Ozenne Peggy , Eymin Beatrice , Brambilla Elisabeth , Gazzeri Sylvie 
Published: June 2010

AbstractThe INK4b‐ARF‐INK4a locus encodes two members of the INK4 family of cyclin‐dependent kinase inhibitors, p15INK4b and p16INK4a, and a completely unrelated protein called ARF. ARF is a nucleolar protein with unusual structure that exhibits tumor suppressive functions. There is growing evidence that ARF signaling is complex, and involves p53‐dependent or ‐independent pathways aiming mainly at restraining abnormal cell growth and at maintaining genomic stability. As such, ARF is a critical component of tumor surveillance, and its expression is decreased in human tumors. In this review, we present the current knowledge on ARF regulation and major functions. The ARF status in human tumors is also briefly summarized.
Glucocorticoids are not always deleterious for bone
Authors: van Lierop Antoon HJM , Hamdy Neveen AT , Papapoulos Socrates E 
Published: June 2010

Abstract
A 23-year-old man with the rare sclerosing bone disorder van Buchem disease presented with progressively worsening headaches that eventually became persistent and associated with papilledema. Increased intracranial pressure was diagnosed, and the patient had a ventriculoperitoneal drain inserted as well as simultaneously receiving treatment with prednisone. Before starting treatment, there was biochemical evidence for increased bone turnover and for steady increases in bone mineral density (BMD) at the spine and total hip despite the patient having reached his peak height of 197 cm at the age of 19 years. Treatment with prednisone for 2 years resulted in biochemical and histologic suppression of bone formation as well as of bone resorption and arrest of further bone accumulation. Our data suggest that glucocorticoids (GCs) may represent an attractive alternative to the high-risk surgical approaches used in the management of patients with progressive sclerosing bone disorders. Our findings also suggest that whereas sclerostin may not be required for the action of GCs on bone formation, it may well be important for the action of GCs on bone resorption. The exact mechanism by which sclerostin may be involved in the regulation of bone resorption is as yet to be explored. © 2010 American Society for Bone and Mineral Research.
Optimization of the production of thiocarbohydrazide using the Taguchi method
Authors: Zhou Jiancheng , Wu Dongfang , Guo Dongsheng 
Published: June 2010

AbstractBACKGROUND: The Taguchi method, a powerful tool for the optimization of quality, was used to improve the yield of thiocarbohydrazide in its synthetic process. An orthogonal array was selected to analyze the effects of the process factors, i.e. reflux time, molar ratio of hydrazine to carbon disulfide and reflux temperature. Experiments were undertaken to confirm the effectiveness of the Taguchi method.RESULTS: Through this study, the main factors that affect the yield of thiocarbohydrazide were found, together with the optimal factor levels. It was shown that the reflux temperature was the most significant factor affecting the yield of thiocarbohydrazide, followed by the molar ratio of hydrazine to carbon disulfide. The optimum factor levels were a reflux time of 6 h, molar ratio of hydrazine to carbon disulfide 3.0 and reflux temperature 70 °C. A 92.3% yield of thiocarbohydrazide was obtained at these optimal factor levels.CONCLUSIONS: The yield of thiocarbohydrazide can be significantly improved by optimization of the synthetic process factors. The Taguchi method provided a systematic and efficient methodology for this optimization, with far less effort than would be required for most other optimization techniques. Copyright © 2010 Society of Chemical Industry