bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of Oxbow Reconnection Based on the Distribution and Structure of Benthic Macroinvertebrates
Authors: Obolewski Krystian , Glińska‐Lewczuk Katarzyna 
Published: August 2011

AbstractThis study focuses on the assessment of relationships between flow and macrozoobenthos structure that was performed in a reconnected oxbow lake located in the Słupia River floodplain (northern Poland). The lake was created during river straightening at the beginning of 20th century by cutting off the right‐bank meander. The oxbow restoration was performed to enhance the ecological viability of this water body and restore riverine wetland. In July 2000 the oxbow was connected with the river channel through PVC pipes which enabled free water movement. Macrozoobenthos sampling, as well as chemical analyses of water and hydrological measurements, took place both before and after the oxbow reconnection. Before the oxbow reconnection, the dominant species was Asellus aquaticus, whereas after the reconnection the structure of benthic species changed significantly. During the first year it was replaced by bivalves and Chironomidae larvae and then A. aquaticus. After the reconnection, macrozoobenthos mean density was 5‐fold higher and the mean wet biomass was 77‐fold higher than before the reconnection. The number of taxa increased from 4 before the oxbow reconnection to 17 during the first year after the performed works and 20 in the next year. We stated that the revitalization process of the reconnected oxbow lake has long‐term consequences for the benthic communities. The most significant feature of the oxbow reconnection is the qualitative and quantitative recolonization by riverine macrozoobenthos species. The performed restoration significantly improved ecological status of the oxbow lake by the increase in biodiversity and water quality.
Electrocortical and behavioral measures of response monitoring in young children during a Go/No‐Go task
Authors: Torpey Dana C. , Hajcak Greg , Kim Jiyon , Kujawa Autumn , Klein Daniel N. 
Published: August 2011

AbstractThe current study examined behavioral measures and response‐locked event‐related brain potentials (ERPs) derived from a Go/No‐Go task in a large (N = 328) sample of 5‐ to 7‐year‐olds in order to better understand the early development of response monitoring and the impact of child age and sex. In particular, the error‐related negativity (ERN, defined on both error trials alone and the difference between error and correct trials, or ΔERN), correct response negativity (CRN), and error positivity (Pe) were examined. Overall, the ERN, CRN, and the Pe were spatially and temporally similar to those measured in adults and older children. Even within our narrow age range, older children were faster and more accurate; a more negative ΔERN and a more positive Pe were associated with: increasing age, increased accuracy, and faster reaction times on errors, suggesting these enhanced components reflected more efficient response monitoring of errors over development. Girls were slower and more accurate than boys, although both genders exhibited comparable ERPs. Younger children and girls were characterized by increased posterror slowing, although they did not demonstrate improved posterror accuracy. Posterror slowing was also related to a larger Pe and reduced posterror accuracy. Collectively, these data suggest that posterror slowing may be unrelated to cognitive control and may, like the Pe, reflect an orienting response to errors. © 2011 Wiley Periodicals, Inc. Dev Psychobiol 54:139‐150, 2012.
Pulling to stand: Common trajectories and individual differences in development
Authors: Atun‐Einy Osnat , Berger Sarah E. , Scher Anat 
Published: August 2011

AbstractThis longitudinal study of 27 infants examined the development of pulling‐to‐stand (PTS). In general, infants began PTS using a two‐leg strategy and transitioned to a half‐kneel strategy. As a group, infants showed no preference for either strategy at the onset of PTS, switching between strategies until half‐kneeling became the dominant pattern about 1 month after the onset of PTS. Examination of individual developmental trajectories revealed variability in age at PTS onset, time between PTS onset and half‐kneel strategy onset, duration of the two‐leg strategy as the dominant pattern, time until the half‐kneel strategy became the dominant pattern, shape of the transition between strategies (gradual vs. abrupt), and timing of PTS relative to onset of other motor milestones. We discuss variation in developmental trajectory in terms of adaptive behavior during the acquisition of new skills and as a process shaped by infants' unique experiences prior to and during the acquisition period. © 2011 Wiley Periodicals, Inc. Dev Psychobiol 54:187‐198, 2012.
Second Generation Calix[6]trenamides – Highly Selective Graftable Receptors for Neutral Guests and Contact Ion Pairs
Authors: Lascaux Angélique , Delahousse Guillaume , Ghostin Jean , Bouillon Jean‐Philippe , Jabin Ivan 
Published: August 2011

AbstractWith the aim of designing graftable calix[6]tren‐based receptors, calix[6]trenamides decorated with an appended functional arm were synthesized through [1+1] macrocyclization reactions between calix[6]trisamines and NTA‐lysine derivatives. NMR spectroscopy and ESI‐MS studies showed that one of these calix[6]trenamides, 5, behaves as a unique heteroditopic receptor towards charged or neutral species. Notably, it can selectively bind contact ammonium fluoride salts through a highly cooperative process. In addition, acid–base control of its binding properties was clearly evidenced. This second generation of graftable receptors opens new perspectives in the design of sensors for charged or neutral species.
Does Information Help Intra‐Day Volatility Forecasts?
Authors: McMillan David G. , García Raquel Quiroga 
Published: August 2011

ABSTRACTWhile much research related to forecasting return volatility does so in a univariate setting, this paper includes proxies for information flows to forecast intra‐day volatility for the IBEX 35 futures market. The belief is that volume or the number of transactions conveys important information about the market that may be useful in forecasting. Our results suggest that augmenting a variety of GARCH‐type models with these proxies lead to improved forecasts across a range of intra‐day frequencies. Furthermore, our results present an interesting picture whereby the PARCH model generally performs well at the highest frequencies and shorter forecasting horizons, whereas the component model performs well at lower frequencies and longer forecast horizons. Both models attempt to capture long memory; the PARCH model allows for exponential decay in the autocorrelation function, while the component model captures trend volatility, which dominates over a longer horizon. These characteristics are likely to explain the success of each model. Copyright © 2013 John Wiley & Sons, Ltd.
The Effect of Humidity and Oxygen Partial Pressure on LSM–YSZ Cathode
Authors: Knöfel C. , Chen M. , Mogensen M. 
Published: August 2011

AbstractTwo series of anode supported solid oxide fuel cells (SOFC) were prepared, one with a composite cathode layer of lanthanum strontium manganite (LSM) and yttria stabilized zirconia (YSZ) on top and the other further has a LSM current collector layer on top. The fuel cells were heat treated at 1,000 °C in air or nitrogen choosing dry or humid (70% steam) conditions. XRD, SEM, and XPS investigations were performed on the various samples. The most severe modifications were observed in humid nitrogen atmosphere at low oxygen partial pressure. LSM surface change goes along with a decrease of manganese concentration and strontium enrichment on the surface of the materials. Formation of monoclinic zirconia and zirconate phases was also observed. These results give a closer insight into possible degradation mechanisms of SOFC composite cathode materials in dependence of humidity and oxygen partial pressure.
Evolution of Water Distribution in PEMFC during On/Off Cycling
Authors: Morin A. , Xu F. , Gebel G. , Diat O. 
Published: August 2011

AbstractThe evolution of membrane water concentration profile has been studied by small angle neutron scattering during on/off cycling PEMFC operation with fully humidified air in co‐flow configuration. The water concentration profiles during on/off cycling evolve in opposite ways close to the gas inlet and outlet. Whereas the global membrane water content increases at the gas inlet as the fuel cell delivers current, the membranes are dried out at the gas outlet. The balance between the diffusion of water from cathode to anode and the electroosmostic drag from anode to cathode gives a net flow which is different close to the gas inlet and gas outlet. The equilibrium is reached in less than 15 min and it is faster when the fuel cell is switched on that is to say when a proton flows is imposed. Moreoever, the time to equilibrium decreases as the membrane content is increased.
Catalytic Steam Methane Reforming Over Ir/Ce0.9Gd0.1O2–x: Resistance to Coke Formation and Sulfur Poisoning
Authors: Postole G. , Girona K. , Toyir J. , Kaddouri A. , Gélin P. 
Published: August 2011

AbstractThis work investigates the catalytic properties of Ir/Ce0.9Gd0.1O2–x (Ir/CGO) catalyst and CGO support in steam reforming of methane in the absence or presence of H2S (50 ppm) for further application in a solid oxide fuel cell (SOFC) working under methane at intermediate temperatures and integrating a gradual internal reforming concept. The catalytic activity was measured at 750 °C by using a 50 mol.% CH4/5 mol.% H2O/45 mol.% N2 mixture and a 10 mol.% CH4/90 mol.% N2 mixture. The addition of Ir to CGO improves the catalytic activity in hydrogen production by two orders of magnitude with respect to that of CGO alone. Temperature programmed oxidation experiments were performed after reaction in both types of mixtures to study the eventual formation of carbon deposits. Over Ir/CGO, carbon formed in little amounts (even in the absence of H2O in the feed), being highly reactive toward O2. Upon H2S addition, the CGO support exhibited surprisingly an improved catalytic activity on the contrary to Ir/CGO which partly deactivated. Upon suppression of H2S in the feed the initial catalytic activity was fully restored for both catalysts. The catalytic behavior of CGO in the presence of H2S was discussed, based upon temperature programmed reaction of CH4.
Multivariate downside risk: Normal versus Variance Gamma
Authors: Wallmeier Martin , Diethelm Martin 
Published: August 2011

AbstractAlthough several types of options on multiple assets are popular in today's financial markets, valuing multiasset options is still a challenge in finance. The standard framework of multivariate normality is often inappropriate, since it ignores fat tails and other stylized facts of asset returns. The variance gamma (VG) model appears to be a promising alternative. In the univariate case, it has become a standard tool in finance. The traditional way to extend the model to the multivariate case is to subordinate a Brownian motion through a univariate subordinator. In recent years, generalizations with multivariate subordinators have been proposed. Our objective is to study two versions of the multivariate VG model in a large‐scale application with multiasset options traded in an active market. Our database consists of 468 multivariate barrier reverse convertibles at the Swiss market for structured products. The Swiss market ranks among the largest in the world and is characterized by an exceptional popularity of multiple asset options. We find that there is a trade‐off between the two VG models considered: one performs better in capturing the smile, the other is more often able to capture the correlation structure. In all, based on our calibration, only 316 of 468 products can be evaluated with at least one of the two VG models. We conclude that there is a need for more flexible extensions. © 2011 Wiley Periodicals, Inc. Jrl Fut Mark
Different DNA damage and cell cycle checkpoint control in low‐ and high‐risk human papillomavirus infections of the vulva
Authors: Santegoets Lindy A.M. , Baars Romy van , Terlou Annelinde , Heijmans‐Antonissen Claudia , Swagemakers Sigrid M.A. , van der Spek Peter J. , Ewing Patricia C. , Beurden Marc van , van der Meijden Willem I. , Helmerhorst Theo J.M. , Blok Leen J. 
Published: August 2011

AbstractHuman papillomavirus (HPV) infections may result in benign hyperplasia, caused by low‐risk HPV types, or (pre)malignant lesions caused by high‐risk HPV types. The molecular basis of this difference in malignant potential is not completely understood. Here, we performed gene profiling of different HPV infected vulvar tissues (condylomata acuminata (n = 5), usual type vulvar intraepithelial neoplasia (uVIN) (n = 9)) and control samples (n = 14) using Affymetrix Human U133A plus 2 GeneChips. Data were analyzed using OmniViz®, Partek® and Ingenuity® Software. Results were validated by real‐time RT‐PCR and immunostaining. Although similarities were observed between gene expression profiles of low‐ and high‐risk HPV infected tissues (e.g., absence of estrogen receptor in condylomata and uVIN), high‐risk HPV infected tissues showed more proliferation and displayed more DNA damage than tissues infected with low‐risk HPV. These observations were confirmed by differential regulation of cell cycle checkpoints and by increased expression of DNA damage‐biomarkers p53 and γH2AX. Furthermore, FANCA, FANCD2, BRCA1 and RAD51, key players in the DNA damage response, were significantly upregulated (p < 0.05). In addition, we compared our results with publicly available gene expression profiles of various other HPV‐induced cancers (vulva, cervix and head‐and‐neck). This showed p16INK4a was the most significant marker to detect a high‐risk HPV infection, but no other markers could be found. In conclusion, this study provides insight into the molecular basis of low‐ and high‐risk HPV infections and indicates two main pathways (cell cycle and DNA damage response) that are much stronger affected by high‐risk HPV as compared to low‐risk HPV.
Specific interactions and binding free energies between thermolysin and dipeptides: Molecular simulations combined with Ab initio molecular orbital and classical vibrational analysis
Authors: Dedachi Kenichi , Hirakawa Tatsuya , Fujita Seiya , Khan Mahmud Tareq Hassan , Sylte Ingebrigt , Kurita Noriyuki 
Published: August 2011

AbstractThermolysin (TLN) is a metalloprotease widely used as a nonspecific protease for sequencing peptide and synthesizing many useful chemical compounds by the chemical industry. It was experimentally shown that the activity and functions of TLN are inhibited by the binding of many types of amino acid dipeptides. However, the binding mechanisms between TLN and dipeptides have not been clarified at the atomic and electronic levels. In this study, we investigated the binding mechanisms between TLN and four dipeptides. Specific interactions and binding free energies (BFEs) between TLN and the dipeptides were calculated using molecular simulations based on classical molecular dynamics and ab initio fragment molecular orbital (FMO) methods. The molecular systems were embedded in solvating water molecules during calculations. The calculated BFEs were qualitatively consistent with the trend of the experimentally observed inhibition of TLN activity by binding of the dipeptides. In addition, the specific interactions between the dipeptides and each amino acid residue of TLN or solvating water molecules were elucidated by the FMO calculations. © 2011 Wiley Periodicals, Inc. J Comput Chem, 2011
Revisiting the origin of the vertebrate Hox14 by including its relict sarcopterygian members
Authors: Feiner Nathalie , Ericsson Rolf , Meyer Axel , Kuraku Shigehiro 
Published: August 2011

AbstractBilaterianHoxgenes play pivotal roles in the specification of positional identities along the anteroposterior axis. Particularly in vertebrates, their regulation is tightly coordinated by tandem arrays of genes [paralogy groups (PGs)] in four gene clusters (HoxA‐D). Traditionally, the uninterruptedHoxcluster (Hox1‐14) of the invertebrate chordate amphioxus was regarded as an archetype of the vertebrateHoxclusters. In contrast to Hox1‐13 that are globally regulated by the “Hox code” and are often phylogenetically conserved, vertebrate Hox14 members were only recently revealed to be present in an African lungfish, a coelacanth, chondrichthyans and a lamprey, and decoupled from the Hox code. In this study we performed a PCR‐based search of Hox14 members from diverse vertebrates, and identified one in the Australian lungfish,Neoceratodus forsteri. Based on a molecular phylogenetic analysis, this gene was designatedNfHoxA14. Our real‐time RT‐PCR suggested its hindgut‐associated expression, previously observed also in cloudy catsharkHoxD14and lampreyHox14α. It is likely that this altered expression scheme was established before theHoxcluster quadruplication, probably at the base of extant vertebrates. To investigate the origin of vertebrate Hox14, by including this sarcopterygian Hox14 member, we performed focused phylogenetic analyses on its relationship with other vertebrate posterior Hox PGs (Hox9‐13) as well as amphioxus posteriorHoxgenes. Our results confirmed the hypotheses previously proposed by other studies that vertebrate Hox14 does not have any amphioxus ortholog, and that none of 1‐to‐1 pairs of vertebrate and amphioxus posteriorHoxgenes, based on their relative location in the clusters, is orthologous.J. Exp. Zool. (Mol. Dev. Evol.) 316:515–525, 2011. © 2011 Wiley Periodicals, Inc.
Dermatofibrosarcoma protuberans: Clinical diagnoses and treatment results of 260 cases in China
Authors: Cai Hong , Wang Yanong , Wu Jianghong , Shi Yingqiang 
Published: August 2011

AbstractBackground and ObjectivesDermatofibrosarcoma protuberans (DFSP) is a low‐grade malignant tumor but has high local recurrence rate. The objectives of this study were to analyze their clinicopathologic factors and review the experience of multidisciplinary treatments.MethodsA total of 260 patients who were treated between 1985 and 2006 in Fudan University Shanghai Cancer Center were evaluated. Outcomes were compared focusing on recurrence and survival. Classical DFSP and transformed DFSP were the two subtypes.ResultsAfter local excision, 50.2% of the patients were found to have residual tumors. The recurrence rate after local excision was significantly higher than that after wide excision (45.0% vs. 8.5%, P < 0.0001). Patients undergoing wide excision with margins ≥3 cm were found to have lower recurrence rate compared with those margins 1.5–2.5 cm (5.7% vs. 13.6%, P = 0.043). Compared with classical DFSPs, transformed DFSPs had significantly higher recurrence rate (34.5% vs. 6.3%, P < 0.0001), higher metastatic rate (23.5% vs. 0.4%, P < 0.0001), and worse prognosis (10‐year survival rate 66.0% vs. 98.6%, P < 0.0001).ConclusionsPerforming adequate initial resection is important for patients with DFSP. Once DFSP was diagnosed, wide excision with a best margin of ≥3 cm is necessary. Transformed DFSPs are more aggressive tumors which need more energetic treatments. J. Surg. Oncol. 2012; 105:142–148. © 2011 Wiley Periodicals, Inc.
Clinical significance of decreased nidogen‐2 expression in the tumor tissue and serum of patients with hepatocellular carcinoma
Authors: Cheng Zhi‐Xiang , Huang Xiao‐Hui , Wang Qian , Chen Jin‐Song , Zhang Long‐Juan , Chen Xi‐Lin 
Published: August 2011

AbstractBackground and ObjectivesNidogen‐2 is a ubiquitous component of basement membrane (BM), which is modified by tumor cells to facilitate tumor invasion. However, the expression and function of nidogen‐2 in hepatocellular carcinoma (HCC) remains unknown at present. In this study, we sought to investigate the potential role of nidogen‐2 in HCC.MethodsNidogen‐2 expression in HCC tissues, cell lines, and serum was evaluated by immunohistochemistry, immunoassay, and real‐time PCR assays. The regulation of nidogen‐2 expression was investigated using doxycycline induction and small interfering RNA analyses.ResultsNidogen‐2 was significantly decreased in both HCC tissues and serum (P < 0.001). The decreased expression of nidogen‐2 in HCC tissues was significantly correlated with tumor progression factors (P < 0.05). Inhibition of matrix metalloproteinase (MMP)‐9 led to significantly upregulate nidogen‐2 expression in vitro assays. Moreover, patients with HCC had lowest serum nidogen‐2 levels compared with patients with benign liver diseases and normal volunteers. Furthermore, the receiver operating characteristic curve analysis revealed a good diagnostic performance of nidogen‐2 for HCC.ConclusionsThese findings suggest that decreased expression of nidogen‐2 may have a potential pathogenetic role in the development of HCC and may also have potential diagnostic value for HCC. J. Surg. Oncol. 2012; 105:71–80. © 2011 Wiley Periodicals, Inc.
Lymph node ratio is an important and independent prognostic factor for patients with stage III melanoma
Authors: Berger Adam C. , Fierro Michael , Kairys John C. , Berd David , Sato Takami , Andrel Jocelyn , Hyslop Terry , Mastrangelo Michael J. 
Published: August 2011

AbstractIntroductionThe incidence of melanoma is dramatically increasing worldwide. We hypothesized that the ratio of metastatic to examined lymph node ratio (LNR) would be the most important prognostic factor for stage III patients.MethodsWe retrospectively reviewed our institutional database of melanoma patients and identified 168 patients who underwent lymph node dissection (LND) for stage III disease between 1993 and 2007. Patients were divided into three groups based on LNR (≤10%, n = 93; 10–≤25%, n = 45; and >25%, n = 30). Univariate and multivariate analysis was performed using Cox proportional hazards model.ResultsThe median survival time of the entire group of patients was 34 months. The median number of positive nodes was 2 (range = 1, 55), and the median number of examined nodes was 22 (range = 5–123). Tumor characteristics of the primary melanoma (such as thickness, ulceration, and primary site) were not significant predictors of survival in this analysis. By univariate analysis, LNR was an important prognostic factor. Patients with LNR 10–25% and >25% had decreased survival compared to those patients with LNR ≤10% (HR = hazard ratio = 2.0 and 3.1, respectively; P ≤ 0.005). The number of positive lymph nodes also impacted on survival (P = 0.001). In multivariate analysis, LNR of 10–25% and >25% predicted survival (HR = 2.5 and 4.0, respectively).ConclusionLNR is an important prognostic factor in patients undergoing LND for stage III melanoma. It can be used to stratify patients being considered for adjuvant therapy trials and should be evaluated using a larger prospective database. J. Surg. Oncol. 2012; 105:15–20. © 2011 Wiley Periodicals, Inc.