bluuebunny/crossref_metadata_2025_split huggingface dataset:
Higher TIGIT+ γδ TCM cells may predict poor prognosis in younger adult patients with non-acute promyelocytic AML
Authors: Hou Qi , Wang Penglin , Kong Xueting , Chen Junjie , Yao Chao , Luo Xiaodan , Li Yangqiu , Jin Zhenyi , Wu Xiuli 
Published: April 2024

Introductionγδ T cells recognize and exert cytotoxicity against tumor cells. They are also considered potential immune cells for immunotherapy. Our previous study revealed that the altered expression of immune checkpoint T-cell immunoreceptor with immunoglobulin and ITIM domain (TIGIT) on γδ T cells may result in immunosuppression and is possibly associated with a poor overall survival in acute myeloid leukemia (AML). However, whether γδ T-cell memory subsets are predominantly involved and whether they have a relationship with clinical outcomes in patients with AML under the age of 65 remain unclear.MethodsIn this study, we developed a multicolor flow cytometry-based assay to monitor the frequency and distribution of γδ T-cell subsets, including central memory γδ T cells (TCM γδ), effector memory γδ T cells (TEM γδ), and TEM expressing CD45RA (TEMRA γδ), in peripheral blood from 30 young (≤65 years old) patients with newly diagnosed non-acute promyelocytic leukemia (also known as M3) AML (AMLy-DN), 14 young patients with AML in complete remission (AMLy-CR), and 30 healthy individuals (HIs).ResultsCompared with HIs, patients with AMLy-DN exhibited a significantly higher differentiation of γδ T cells, which was characterized by decreased TCM γδ cells and increased TEMRA γδ cells. A generally higher TIGIT expression was observed in γδ T cells and relative subsets in patients with AMLy-DN, which was partially recovered in patients with AMLy-CR. Furthermore, 17 paired bone marrow from patients with AMLy-DN contained higher percentages of γδ and TIGIT+ γδ T cells and a lower percentage of TCM γδ T cells. Multivariate logistic regression analyses revealed the association of high percentage of TIGIT+ TCM γδ T cells with an increased risk of poor induction chemotherapy response.ConclusionsIn this study, we investigated the distribution of γδ T cells and their memory subsets in patients with non-M3 AML and suggested TIGIT+ TCM γδ T cells as potential predictive markers of induction chemotherapy response.
The causal relationship between sarcoidosis and autoimmune diseases: a bidirectional Mendelian randomization study in FinnGen
Authors: Sun Di , Ma Ruimin , Wang Jingwei , Wang Yuanying , Ye Qiao 
Published: April 2024

BackgroundSarcoidosis has been considered to be associated with many autoimmune diseases (ADs), but the cause-and-effect relationship between these two diseases has not been fully explored. Therefore, the objective of this study is to explore the possible genetic association between sarcoidosis and ADs.MethodsWe conducted a bidirectional Mendelian randomization (MR) study using genetic variants associated with ADs and sarcoidosis (4,041 cases and 371,255 controls) from the FinnGen study. The ADs dataset comprised 96,150 cases and 281,127 controls, encompassing 44 distinct types of autoimmune-related diseases. Subsequently, we identified seven diseases within the ADs dataset with a case size exceeding 3,500 and performed subgroup analyses on these specific diseases.ResultsThe MR evidence supported the causal association of genetic predictors of ADs with an increased risk of sarcoidosis (OR = 1.79, 95% CI = 1.59 to 2.02, P IVW-FE = 1.01 × 10-21), and no reverse causation (OR = 1.05, 95% CI 0.99 to 1.12, PIVW-MRE = 9.88 × 10-2). Furthermore, subgroup analyses indicated that genetic predictors of type 1 diabetes mellitus (T1DM), celiac disease, and inflammatory bowel disease (IBD) were causally linked to an elevated risk of sarcoidosis (All P &lt; 6.25 × 10-3). Conversely, genetic predictors of sarcoidosis showed causal associations with a higher risk of type 1 diabetes mellitus (P &lt; 6.25 × 10-3).ConclusionThe present study established a positive causal relationship between genetic predictors of ADs (e.g. T1DM, celiac disease, and IBD) and the risk of sarcoidosis, with no evidence of reverse causation.
Differences in the intestinal microbiota and association of host metabolism with hair coat status in cattle
Authors: Wu Donglin , Zhao Pengfei , Wang Chunjie , Huasai Simujide , Chen Hao , Chen Aorigele 
Published: April 2024

IntroductionThe hair coat status of cattle serves as an easily observed indicator of economic value in livestock production; however, the underlying mechanism remains largely unknown. Therefore, the objective of the current study was to determine differences in the intestinal microbiota and metabolome of cattle based on a division of with either slick and shining (SHC) or rough and dull (MHC) hair coat in Simmental cows.MethodsEight SHC and eight MHC late-pregnancy Simmental cows (with similar parities, body weights, and body conditions) were selected based on their hair coat status, and blood samples (plasma) from coccygeal venipuncture and fecal samples from the rectum were collected. The intestinal microbiota (in the fecal samples) was characterized by employing 16S rRNA gene sequencing targeting the V3–V4 hypervariable region on the Illumina MiSeq PE300 platform, and plasma samples were subjected to LC–MS/MS-based metabolomics with Progenesis QI 2.3. Plasma macromolecular metabolites were examined for differences in the metabolism of lipids, proteins, mineral elements, and hormones.ResultsNotable differences between the SHC and MHC groups related to host hair coat status were observed in the host metabolome and intestinal microbiota (P &lt; 0.05). The host metabolome was enriched in histidine metabolism, cysteine and methionine metabolism, and purine metabolism in the SHC group, and the intestinal microbiota were also enriched in histidine metabolism (P &lt; 0.05). In the MHC group, the symbiotic relationship transitioned from cooperation to competition in the MHC group, and an uncoupling effect was present in the microbe–metabolite association of intestine microbiota–host interactions. The hubs mediating the relationships between intestinal microbiota and plasma metabolites were the intestinal bacterial genus g__norank_f__Eubacterium_coprostanoligenes_group, plasma inosine, triiodothyronine, and phosphorus, which could be used to differentiate cows’ hair coat status (P &lt; 0.05).ConclusionOverall, the present study identified the relationships between the features of the intestinal microbiota and host hair coat status, thereby providing evidence and a new direction (intestine microbiota–host interplay) for future studies aimed at understanding the hair coat status of cattle.
Functional impact of bilateral vestibular loss and the unexplained complaint of oscillopsia
Authors: Geisinger Dario , Elyoseph Zohar , Zaltzman Roy , Mintz Matti , Gordon Carlos R. 
Published: April 2024

IntroductionThe vestibulo-ocular reflex (VOR) stabilizes vision during head movements. VOR disorders lead to symptoms such as imbalance, dizziness, and oscillopsia. Despite similar VOR dysfunction, patients display diverse complaints. This study analyses saccades, balance, and spatial orientation in chronic peripheral and central VOR disorders, specifically examining the impact of oscillopsia.MethodsParticipants involved 15 patients with peripheral bilateral vestibular loss (pBVL), 21 patients with clinically and genetically confirmed Machado–Joseph disease (MJD) who also have bilateral vestibular deficit, and 22 healthy controls. All pBVL and MJD participants were tested at least 9 months after the onset of symptoms and underwent a detailed clinical neuro-otological evaluation at the Dizziness and Eye Movements Clinic of the Meir Medical Center.ResultsAmong the 15 patients with pBVL and 21 patients with MJD, only 5 patients with pBVL complained of chronic oscillopsia while none of the patients with MJD reported this complaint. Comparison between groups exhibited significant differences in vestibular, eye movements, balance, and spatial orientation. When comparing oscillopsia with no-oscillopsia subjects, significant differences were found in the dynamic visual acuity test, the saccade latency of eye movements, and the triangle completion test.DiscussionEven though there is a significant VOR gain impairment in MJD with some subjects having less VOR gain than pBVL with reported oscillopsia, no individuals with MJD reported experiencing oscillopsia. This study further supports that subjects experiencing oscillopsia present a real impairment to stabilize the image on the retina, whereas those without oscillopsia may utilize saccade strategies to cope with it and may also rely on visual information for spatial orientation. Finding objective differences will help to understand the causes of the oscillopsia experience and develop coping strategies to overcome it.
Relationship between depression and sex steroid hormone among women with epilepsy
Authors: Ogunjimi Luqman , Alabi Akinyinka , Oyenuga Ibironke , Ogunkunle Jeremiah , Kasumu Emmanuel , Ogunsanya Oluwaseun , Oluseyije Oluwatobiloba , Ogunbayo Pelumi , Idume Omorojo , Kasali Adeola , Adesi Sarah , Oyebowale Mariam , Ogungbemi Damilola , Aderinola Aderonke , Irokosu Emmanuel , Murtala Abdullahi , Osalusi Bamidele 
Published: April 2024

IntroductionSex steroid hormones are emerging significant biomarkers of depression among Women with Epilepsy (WWE) with promising prognostic potential and therapeutic end point. Therefore, the study is aimed at exploring the association between sex steroids hormones, Anti-seizure Medication (ASM) and depression among WWE.MethodologyA baseline questionnaire was used to obtain socio-demographics and clinical characteristic from one hundred and twelve (112) WWE and 50 age matched healthy control. The diagnosis of epilepsy and Electroencephalography (EEG) description was based on 2017 International League Against Epilepsy (ILAE) criteria. Blood samples were collected from cases and control during Luteal Phase (LP) and Follicular Phase (FP). The Zung Self-Rating Depression Scale (ZSRDS) was used to assess depression.ResultThe prevalence of depression among WWE is 18.8%, with a significant difference between the level of formal education (p0.000), age (p0.000), and mean ZSRDS (p0.000) among cases and control. There is a statistical difference in hormonal levels between cases and control with regards to higher testosterone [3.28 ± 9.99 vs. 0.31 ± 0.30; p0.037], lower FP prolactin [16.37 ± 20.14 vs. 17.20 ± 7.44; p0.778], and lower LP prolactin [15.74 ± 18.22 vs. 17.67 ± 7.27; p0.473]. Testosterone (p0.024), FP Follicle Stimulating Hormone (FSH) (p0.009), FP Estradiol (p0.006), LP FSH (p0.031), LP Progesterone (p0.023), and LP Prolactin (p0.000) were associated with depression. However, only prolactin (p0.042) and testosterone (p0.000) predicts depression among WWE.ConclusionThere was higher mean depression score, lower prolactin and higher testosterone level among cases compared to control. Furthermore, there was lower prolactin and higher testosterone level in Carbamazepine (CBZ) group compared to Levetiracetam (LEV) groups.
The influence of digital platform on the implementation of corporate social responsibility: from the perspective of environmental science development to explore its potential role in public health
Authors: Wang Mansi , Yuan Renmiao , Guan Xin , Wang Zeyu , Zeng Yanzhao , Liu Tao 
Published: April 2024

IntroductionThis paper aims to explore the intersection of corporate social responsibility (CSR) and public health within the context of digital platforms. Specifically, the paper explores the impact of digital platforms on the sustainable development practices of enterprises, seeking to comprehend how these platforms influence the implementation of environmental protection policies, resource management, and social responsibility initiatives.MethodsTo assess the impact of digital platforms on corporate environmental behavior, we conducted a questionnaire survey targeting employees in private enterprises. This survey aimed to evaluate the relationship between the adoption of digital platforms and the implementation of environmental protection policies and practices.ResultsAnalysis of the survey responses revealed a significant positive correlation between the use of digital platforms and the environmental protection behavior of enterprises (r=0.523;p<0.001), Moreover, the presence of innovative environmental protection technologies on these platforms was found to positively influence the enforcement of environmental policies, with a calculated impact ratio of (a∗b/c=55.31%). An intermediary analysis highlighted that environmental innovation technology plays a mediating role in this process. Additionally, adjustment analysis showed that enterprises of various sizes and industries respond differently to digital platforms, indicating the need for tailored environmental policiesDiscussionThese findings underscore the pivotal role of digital platforms in enhancing CSR efforts and public health by fostering improved environmental practices among corporations. The mediating effect of environmental innovation technologies suggests that digital platforms not only facilitate direct environmental actions but also enhance the efficiency and effectiveness of such initiatives through technological advances. The variability in response by different enterprises points to the importance of customizable strategies in policy formulation. By offering empirical evidence of digital platforms’ potential to advance CSR and public health through environmental initiatives, this paper contributes to the ongoing dialogue on sustainable development goals. It provides practical insights for enterprises and policy implications for governments striving to craft more effective environmental policies and strategies.
In-classroom physical activity breaks program among school children in Sri Lanka: study protocol for a randomized controlled trial
Authors: Peiris D. L. I. H. K. , Duan Yanping , Vandelanotte Corneel , Liang Wei , Baker Julien Steven 
Published: April 2024

BackgroundThe problem of sedentary behavior among primary school children is alarming, with numbers gradually increasing worldwide, including Sri Lanka. Physical activity interventions within classroom settings have been acknowledged as a critical strategy to increase students’ movement behaviors while enhancing their academic achievement and health. Yet, the busy curriculum and challenging educational demands encourage more sedentary classroom behavior. Hence, this study aims to develop and evaluate an in-classroom physical activity breaks (IcPAB) intervention among fifth graders in Sri Lanka.MethodsThe study will adopt a randomized controlled trial (RCT), comprising an in-classroom physical activity breaks program group and a control group to evaluate the effects of IcPAB on academic achievement, movement behaviors and health outcomes. The intervention design is based on the capability (C), opportunity (O) and motivation (M) behavior (B) (COM-B) model. A least 198 fifth graders will be recruited from two schools in Uva province, Sri Lanka. The recruitment process will start in late 2022. Class teachers of the intervention group will implement 5-min activity breaks at least three times a day after completing a training session. The primary variables include mathematics and reading achievement. The secondary variables include physical activity levels, steps count, sedentary behavior, body mass index, aerobic fitness, and perceived stress. Data collection will be implemented at pre-test and post-test, respectively. Intervention fidelity and the process will also be evaluated.DiscussionThe IcPAB is designed to prevent pure educational time loss by introducing curriculum-integrated short bouts of physical active breaks into the classroom routine. If the IcPAB is effective, it can (1) improve the mathematics and reading achievement of fifth-grade girls and boys, which is a significant factor determining the performance at the Grade Five National Scholarship Examination in Sri Lanka; (2) improve movement behaviors as well as physical and mental health outcomes among primary school students. Sequentially, the IcPAB will enrich school-based physical activity intervention approaches which can in turn bring academic and health benefits to primary school children in Sri Lanka.Trial registrationThe first version of the trial was registered with the ISRCTN registry (Ref: ISRCTN52180050) on 20/07/2022.
Two-Pion Bose–Einstein Correlations in Au+Au Collisions at sNN = 3 GeV in the STAR Experiment
Authors: Kraeva Anna 
Published: April 2024

The correlation femtoscopy technique makes it possible to estimate the geometric dimensions and lifetime of the particle emission region after the collision of ions. Measurements of the emission region characteristics not only at midrapidity but also at backward (forward) rapidity can provide new information about the source and make it possible to impose constraints on the heavy-ion collision models. This work is devoted to revealing the dependence of the spatial and temporal parameters of the emission region of identical pions in Au+Au collisions at sNN = 3 GeV from the fixed-target program of the STAR experiment. The extracted femtoscopic radii, Rout, Rside, Rlong, Rout−long2, and the correlation strength, λ, are presented as a function of collision centrality, pair rapidity, and transverse momentum. Physics implications will be discussed.
Long-Term Care Healthcare-Associated Infections in 2023: An Analysis of 23,970 Reports
Authors: Kepner Shawn , Bennett Amanda , Jones Rebecca 
Published: April 2024

Background The Pennsylvania Patient Safety Reporting System (PA-PSRS) is the largest database of patient safety event reports in the United States. In addition to over 4.7 million acute care reports, the PA-PSRS database contains more than 420,000 long-term care (LTC) healthcare-associated infection (HAI) reports. Methods LTC HAI data from PA-PSRS were extracted on March 1, 2024. Infection counts were calculated based on report submission date and rates were calculated based on infection confirmation date. Reports submitted by LTC facilities and specific care areas were included for infection rates each month if resident and device days were also entered in PA-PSRS for the facility and care area. Results A total of 23,970 infection reports were submitted by Pennsylvania’s LTC facilities in 2023, representing an 18.6% increase from 2022. The overall infection rate increased by 11.4%, from 0.88 in 2022 to 0.98 in 2023, and all six regions of the state had an increase in infection rate. The Northeast region had the highest rate, with 1.28 reports per 1,000 resident days, and the Southeast region had the lowest rate, at 0.72. The overall rate increase was driven by rates of urinary tract infection (UTI) and skin and soft tissue infection (SSTI), which increased by 20.1% and 17.4%, respectively. Within the UTI infection type, symptomatic urinary tract infection (SUTI) rates increased by 21.1% and catheter-associated urinary tract infection (CAUTI) rates increased by 11.8%. Conclusion There was an increase in the total number and rate of infections reported to PA-PSRS in 2023.
Analisis Perbandingan Kualitas Minyak Goreng Berdasarkan Parameter Asam Lemak Bebas
Authors: Jannah Nurul , La Daiba Yuniar 
Published: April 2024

Palm cooking oil is a basic need for people in Indonesia. Heating the palm cooking oil for a long time can decreased the quality of the oil, one of them is free fatty acid parameter. This study aims to determine the free fatty acids in samples of new cooking oil and cooking oil after used. Analysis of oil quality was observed based on organoleptic and free fatty acid (FFA) parameters. The FFA value in cooking oil was carried out using the titration method, while organolepic was obtained by sensory observation. The samples were new cooking oil (A), cooking oil used twice ( B) and cooking oil used more than twice (C). The results showed that the free fatty acid value in sample A met the SNI standard (< 0.3), namely 0.0799, while the free fatty acid value in samples B and C was higher than the SNI standard, namely 0.3062 and 0.3915. Statistical analysis showed that there was a significant difference in the free fatty acid values in sample A compared to samples B and C (p<0.05). Based on this research, it can be concluded that repeated heating of cooking oil can increase the free fatty acid value significantly.

ABSTRAK
Minyak goreng menjadi kebutuhan pokok masyarakat di Indonesia. Pemanasan minyak goreng dalam waktu lama dapat menyebabkan penurunan kualitas minyak, salah satunya di parameter asam lemak bebas. Penelitian ini bertujuan untuk mengetahui perbedaan asam lemak bebas dalam sampel minyak goreng baru dan minyak goreng setelah digunakan. Analisis kualitas minyak diamati berdasarkan organoleptik dan parameter asam lemak bebas (ALB). Nilai ALB dalam minyak goreng dilakukan dengan metode titrasi, sedangkan organolepik diperoleh dengan pengamatan indera. Sampel berupa minyak goreng baru (sampel A), minyak goreng 2 kali pakai (sampel B) dan minyak goreng lebih dari 2 kali pakai (sampel C). Hasil penelitian menunjukan nilai asam lemak bebas pada sampel A memenuhi standar SNI (< 0,3) yaitu 0,0799, sedangkan asam lemak bebas pada sampel B dan C lebih tinggi dari standar SNI, yaitu 0,3062 dan 0,3915. Analisis statistik menunjukan adanya perbedaan bermakna nilai asam lemak bebas pada sampel A dibandingkan dengan sampel B dan C (p<0,05). Berdasarkan penelitian ini dapat disimpulkan bahwa pemanasan berulang pada minyak goreng dapat meningkatkan nilai asam lemak bebas secara signifikan.
Analysis on performances of ultra-thin vertical MOSFET depending on position of gate–drain misalignment
Authors: Kim Soomin , Cho Seongjae 
Published: April 2024

Abstract
In advanced MOSFET design, a vertical-channel structure provides the advantages of a smaller footprint of the transistor cell and stronger immunity against short-channel effects by introducing higher freedom in determining the channel length. For these reasons, vertical devices are still predicted to be an upcoming solution in the most recent technology roadmap. However, due to the cell-to-cell or wafer-to-wafer processing deviation that inevitably exists, it can be quite challenging to locate the gate edges at the exact positions that maximize the device performance. In this work, a series of technology computer-aided design (TCAD) device simulations have been carried out to investigate the effects of gate underlap and overlap structures on the device performance of vertical-channel MOSFETs. The device characterizations were conducted from the aspects of both DC and HF operations for higher completeness of this work, since both are not usually optimized at the same time under the same structural and processing conditions. Under the underlap condition, slight degradation in the on-state current (I
on) drivability was observed. On the other hand, a noticeable off-state current (I
off) increase was witnessed under the underlap conduction. It is explicitly demonstrated that excessive gate underlap results in non-ideal effects, including degradation of the subthreshold swing (S), worsening of drain-induced barrier lowering, and lowering of the maximum transconductance (g
m,Max). In the HF analyses, although f
T and f
max remained high under overlap and gate–drain alignment conditions, it was observed that both were likely to deteriorate under underlap conditions. As a result, a processing margin in the anisotropic etching of the gate can be obtained for the optimization of the DC and HF performance of vertical-channel MOSFETs, paving the way for a wide variety of low-power and high-speed analog and digital applications.