bluuebunny/crossref_metadata_2025_split huggingface dataset:
Space-time generalization of mutual information
Authors: Glorioso Paolo , Qi Xiao-Liang , Yang Zhenbin 
Published: June 2024

Abstract
The mutual information characterizes correlations between spatially separated regions of a system. Yet, in experiments we often measure dynamical correlations, which involve probing operators that are also separated in time. Here, we introduce a space-time generalization of mutual information which, by construction, satisfies several natural properties of the mutual information and at the same time characterizes correlations across subsystems that are separated in time. In particular, this quantity, that we call the space-time mutual information, bounds all dynamical correlations. We construct this quantity based on the idea of the quantum hypothesis testing. As a by-product, our definition provides a transparent interpretation in terms of an experimentally accessible setup. We draw connections with other notions in quantum information theory, such as quantum channel discrimination. Finally, we study the behavior of the space-time mutual information in several settings and contrast its long-time behavior in many-body localizing and thermalizing systems.
The rise and fall of the Standard-Model Higgs: electroweak vacuum stability during kination
Authors: Laverda Giorgio , Rubio Javier 
Published: June 2024

Abstract
In this paper we investigate the vacuum stability of the non-minimally coupled Standard-Model Higgs during a phase of kinetic domination following the end of inflation. The non-minimal coupling to curvature stabilises the Higgs fluctuations during inflation while driving them towards the instability scale during kination, when they can classically overcome the potential barrier separating the false electroweak vacuum from the true one at super-Planckian field values. Avoiding the instability of the Standard-Model vacuum sets an upper bound on the inflationary scale that depends both on the strength of the non-minimal interaction and on the top quark Yukawa coupling. Classical vacuum stability is guaranteed if the gravitationally-produced energy density is smaller than the height of barrier in the effective potential. Interestingly enough, thanks to the explosive particle production in the tachyonic phase, the Higgs itself can be also appointed to the role of reheaton field responsible for the onset of the hot Big Bang era, setting an additional lower bound on the inflationary scale $$ {\mathcal{H}}_{\textrm{inf}} $$

H
inf

≳ 105.5 GeV. Overall, these constraints favour lower masses for the top quark, in agreement with the current measurements of the top quark pole mass. We perform our analysis semi-analytically in terms of the one-loop and three-loop running of the Standard-Model Higgs self-coupling and make use of lattice-based parametric formulas for studying the (re)heating phase derived in arXiv:2307.03774. For a specific choice of mt = 171.3 GeV we perform also an extensive numerical scanning of the parameter space via classical lattice simulations, identifying stable/unstable regions and supporting the previous analytical arguments. For this fiducial value, the heating of the Universe is achieved at temperatures in the range 10−2–109 GeV.
Trace operators on bounded subanalytic manifolds
Authors: Valette Anna , Valette Guillaume 
Published: June 2024

AbstractWe prove that if $$M\subset {\mathbb {R}}^n$$

M
⊂

R

n

is a bounded subanalytic submanifold of $${\mathbb {R}}^n$$

R

n

such that $${\textbf{B}}(x_0,\varepsilon )\cap M$$

B
(

x
0

,
ε
)
∩
M

is connected for every $$x_0\in {{\overline{M}}}$$

x
0

∈

M
¯

and $$\varepsilon >0$$

ε
>
0

small, then, for $$p\in [1,\infty )$$

p
∈
[
1
,
∞
)

sufficiently large, the space $${\mathscr {C}}^\infty ( {{\overline{M}}})$$

C

∞

(

M
¯

)

is dense in the Sobolev space $$W^{1,p}(M)$$

W

1
,
p

(
M
)

. We also show that for p large, if $$A\subset {{\overline{M}}}\setminus M$$

A
⊂

M
¯

\
M

is subanalytic then the restriction mapping $$ {\mathscr {C}}^\infty ( {{\overline{M}}})\ni u\mapsto u_{|A}\in L^p(A)$$

C

∞

(

M
¯

)

∋
u
↦

u

|
A

∈

L
p

(
A
)

is continuous (if A is endowed with the Hausdorff measure), which makes it possible to define a trace operator, and then prove that compactly supported functions are dense in the kernel of this operator. We finally generalize these results to the case where our assumption of connectedness at singular points of $$ {{\overline{M}}}$$

M
¯

is dropped.
Apixaban plasma concentrations in patients with obesity
Authors: Al-Aieshy Fadiea , Skeppholm Mika , Fyrestam Jonas , Johansson Fredrik , Pohanka Anton , Malmström Rickard E. 
Published: June 2024

Abstract
Purpose
Routine therapeutic drug monitoring of apixaban is currently not recommended but may however be warranted in some situations and for some patient groups to provide better and safer treatment. Due to limited data on apixaban concentrations in different subpopulations, it is still unclear which group of patients could possibly gain from monitoring. The purpose of this study was to examine apixaban exposure in patients with obesity compared with normal-weight patients.

Methods
Forty patients with obesity (mean BMI 39.4 kg/m2) and 40 controls with normal weight (mean BMI 23.4 kg/m2), treated with apixaban 5 mg twice daily were included. The patients were matched for age, sex, and renal function. Trough and peak apixaban concentrations were measured with LC‒MS/MS methodology.

Results
The median trough concentrations in patients with obesity (58.7, range 10.7–200.7 ng/ml) were slightly higher than those in patients with normal weight (52.0, range 31.0–150.9 ng/ml) (p < 0.05). Notably, the variability in trough concentration was considerably higher in patients with obesity. Peak concentrations were similar in both groups, with a median of 124.5 ng/ml (range 82.0–277.5) and 113.5 ng/ml (range 75.5–334.6) in patients with obesity and normal weight, respectively.

Conclusion
Apixaban exposure did not vary substantially between obese and normal weight matched controls, implying that general dose adjustments are not required. However, vast interindividual variability was observed in patients with obesity, suggesting that measuring the concentrations could be valuable for specific patients. Further research is needed to identify which specific patients may benefit from this approach.
Impact of fixation method on femoral bone loss: a retrospective evaluation of stem loosening in first-time revision total hip arthroplasty among two hundred and fifty five patients
Authors: Wagener Nele , Pumberger Matthias , Hardt Sebastian 
Published: June 2024

Abstract
Purpose
Implant loosening represent the most common indication for stem revision in hip revision arthroplasty. This study compares femoral bone loss and the risk of initial revisions between cemented and uncemented loosened primary stems, investigating the impact of fixation method at primary implantation on femoral bone defects.

Methods
This retrospective study reviewed 255 patients who underwent their first revision for stem loosening from 2010 to 2022, receiving either cemented or uncemented stem implants. Femoral bone loss was preoperatively measured using the Paprosky classification through radiographic evaluations. Kaplan-Meier analysis estimated the survival probability of the original stem, and the hazard ratio assessed the relative risk of revision for uncemented versus cemented stems in the first postoperative year and the following two to ten years.

Results
Cemented stems showed a higher prevalence of significant bone loss (type 3b and 4 defects: 32.39% vs. 2.72%, p < .001) compared to uncemented stems, which more commonly had type 1 and 2 defects (82.07% vs. 47.89%, p < .001). In our analysis of revision cases, primary uncemented stems demonstrated a 20% lower incidence of stem loosening in the first year post-implantation compared to cemented stems (HR 0.8; 95%-CI 0.3-2.0). However, the incidence in uncemented stems increased by 20% during the subsequent years two to ten (HR 1.2; 95%-CI 0.7–1.8). Septic loosening was more common in cemented stems (28.17% vs. 10.87% in uncemented stems, p = .001). Kaplan-Meier analysis indicated a modestly longer revision-free period for cemented stems within the first ten years post-implantation (p < .022).

Conclusion
During first-time revision, cemented stems show significantly larger femoral bone defects than uncemented stems. Septic stem loosening occurred 17.30% more in cemented stems.
Antibacterial activity of 3D printed thermoplastic elastomers doped with carbon quantum dots for biomedical applications
Authors: Shaalan Mohamed , Vykydalová Anna , Švajdlenková Helena , Kroneková Zuzana , Marković Zoran M. , Kováčová Mária , Špitálský Zdenko 
Published: June 2024

Abstract3D printing provides a lot of varieties for the manufacturing of personalized biomedical devices. Incorporation of the nanoparticles with potential antibacterial activity to the printed materials is another added value. One example of such nanoparticles are hydrophobic carbon quantum dots (hCQDs), which are zero-dimensional redox-active materials with high chemical stability and low production costs. They produce singlet oxygen only when activated by a specific wavelength of visible blue light which allows for controlled antibacterial action and minimizes the chances of bacterial resistance emergence. We prepared and characterized polymer composites based on thermoplastic elastomers (TPE) doped with hCQDs (TPE/hCQDs). The composites were 3D printed using fused deposition modeling method. In the first set of samples, a filament of pure TPE was immersed in a solution of hCQDs (0.5 mg/mL), then 3D printed, and compared with unmodified TPE filament. The mechanical properties, swelling behavior, hardness, and thermal stability of TPE/hCQDs were compared with the pure TPE printed samples. The production of singlet oxygen was confirmed by the electron paramagnetic resonance method. The antibacterial activity of the samples was tested according to ISO 22196 against Staphylococcus aureus and Escherichia coli after one hour of exposure to blue light, which completely inhibited bacterial growth. Besides, the cytotoxicity of samples was evaluated by MTT assay, and no significant effect of the materials on cell viability was observed. 3D printed materials with antibacterial activity represent a perspective for the future, especially in the field of personalized medicine, as well as in products for other industries.
Infrared thermography techniques for boundary layer state visualisation
Authors: Davis William , Atkins Nicholas R. 
Published: June 2024

AbstractThe rapid decarbonisation of the power generation and aviation sectors will require a move away from incremental development, exposing designers and researchers to the risk of unexpected results from uncertainty in boundary layer state. This problem already exists for parts developed with fully turbulent assumptions, but in novel design spaces the risk increases for both real components, where previous knowledge of similar designs may be inapplicable, and particularly in experimental testing of scaled models, where reducing Reynolds number can result in a drastic change in flow topology that skews the conclusions of a test. Computational methods struggle to reliably predict boundary layer state so experimental techniques for diagnosing boundary layer state are needed. Infrared thermography (IR) is a non-invasive technique that offers simple, fast visualisation of boundary layer state with no additional instrumentation. IR is relatively uncommon in the literature and there is minimal information available on the best practices for its use. This paper aims to encourage the adoption of IR as a diagnostic tool by demonstrating routes for optimisation and pointing out pitfalls to avoid. A low-order model is developed and used to predict how the signal-to-noise ratio (SNR) of an IR visualisation changes depending on the thermal design of the test piece. It is shown that in low-speed flows with active heating from the surface the SNR is maximised through a suitable choice of surface insulation, while in high-speed flows, where passive temperature differences are used, there is a crossover between heat transfer and recovery temperature effects that results in an SNR of zero, an effect that can arise in both steady-state and transient experiments. Experimental validation of the 1D model in both flow regimes is shown alongside two case studies on the use of IR in sub-scale testing where uncertainty in boundary layer state results in critical differences from the full-scale flow.
Intralesional acyclovir versus intralesional Hepatitis-B vaccine in treatment of resistant plantar warts: a randomized controlled trial
Authors: Gharib Khalid , Taha Aya , Elradi Mona 
Published: June 2024

AbstractTreating plantar warts is still a challenging problem with a long list of diverse treatment options that none of them seems to be definitive. To evaluate the effectiveness of intralesional acyclovir versus intralesional Hepatitis-B vaccine (HBV) in treatment of multiple resistant plantar warts. Forty-eight patients with resistant plantar warts completed the study with no dropouts. They were randomized into 3 groups; group(A) receiving intralesional HBV, group (B) receiving intralesional acyclovir and group (C) receiving intralesional saline as a control group over 5 biweekly sessions or until wart clearance. Clinical outcome was assessed through sequential digital lesion photographing upon each visit. Treatment related adverse reactions were recorded. 43.8%, 37.5% & 18.7% of Groups A, B &C respectively showed a complete response. pain was obvious in 100% and 56.3% of cases receiving intralesional acyclovir and HBV respectively. Up to the 6 month follow up period, none of the complete responders in all groups returned with a recurrence. Both acyclovir and HBV showed comparable efficacy and seem to be promising options for treating plantar warts being safe, affordable, and theoretically safe in immunocompromised cases.
Atypical localized Mongolian spots in dark pigmented skin - a challenge for forensic medical examination
Authors: Schlepper Stefanie , Hagen M. , Schulz R. , Schmeling A. 
Published: June 2024

AbstractThe assessment of skin changes in the context of possible child abuse is an important task in forensic medicine. This requires knowledge of pigmentation variants and pigmentation disorders such as congenital dermal melanocytosis, which includes Mongolian spots. Particularly in the case of atypical localization and dark pigmented skin, the differentiation from hematomas can be challenging. A case of two Nigerian siblings with extensive and atypically localized Mongolian spots is reported. The 1.5-year-old girl showed Mongolian spots on her back and the right side of her trunk. The 8-year-old boy showed Mongolian spots only on the back of his thighs. The authors are not aware of any case in which so called Mongolian spots were present exclusively on the back of the thighs and this case is all the more noteworthy as the back of the thigh is a common localization of blunt force trauma.
Presence of Cryptosporidium parvum in pre-washed vegetables from different supermarkets in South East England: A pilot study
Authors: Suleiman Aisha Jamo , Mavrides Daphne E. , Maxamhud Sadiya , Gentekaki Eleni , Tsaousis Anastasios D. 
Published: June 2024

AbstractCryptosporidium is an important water-borne and food-borne parasite with a high burden of disease. This organism has been shown to contaminate various leafy vegetables; however, studies assessing the presence of Cryptosporidium spp in pre-washed and ready-to-eat vegetables are limited. Routine surveillance in the UK revealed a nationwide exceedance of human cases of Cryptosporidium. Therefore, this study aims to assess the presence of this parasite in pre-washed vegetables from supermarkets in the UK. A total of 36 samples were purchased from four different supermarkets. A nested PCR targeting the SSU rRNA was carried out on 24 samples, 58% were PCR-positive for Cryptosporidium. Sanger sequencing confirmed that, of these sequences, 4/24 (17%) produced significant similarities to Cryptosporidium parvum. This study provides evidence for the presence of C. parvum in pre-washed and ready-to-eat vegetables. Future work to identify the point of contamination is required.
Review: Andesitic aquifers—hydrogeological conceptual models and insights relevant to applied hydrogeology
Authors: Baud B. , Lachassagne P. , Dumont M. , Toulier A. , Hendrayana Heru , Fadillah Arif , Dorfliger N. 
Published: June 2024

AbstractResearch on the hydrogeology of andesitic volcanic aquifers in subduction areas is reviewed. Andesitic aquifers are of high interest in volcanic arc islands and subduction zones, where they constitute a strategic water resource. This review gathers a compilation of worldwide results and case studies to propose a generic hydrogeological conceptual model (GHCM). It is based on the geological conceptual model splitting the volcanic edifice, from upstream to downstream, into central, proximal, medial and distal zones. In this geological structure, the GHCM identifies where the main aquifer types (fractured lava, pyroclastic flows, and the volcano-sedimentary basins downstream) and the typical aquitards (lahars, fine pyroclastic falls and surges, indurated pyroclastic flow, and weathered rocks) are structured and organized. To integrate the evolution of volcanoes and some specific volcanic activities, a specific GHCM for old andesitic volcanoes or andesitic shield volcanoes is detailed. The paper also describes how the GHCM results are of use to hydrogeologists in terms of scale (from the lithological units to the regional scale), to effectively site water wells, and to sustainably manage groundwater resources in such aquifers. Among these various scales, the volcanic “flank continuum” is presented as the most adapted to support groundwater resources management. Several ways to improve this GHCM are suggested, notably to better consider the geological complexity of these aquifers.
Anthracene detoxification by Laccases from indigenous fungal strains Trichoderma lixii FLU1 and Talaromyces pinophilus FLU12
Authors: Egbewale Samson O. , Kumar Ajit , Olasehinde Tosin A. , Mokoena Mduduzi P. , Olaniran Ademola O. 
Published: June 2024

AbstractThe persistence and ubiquity of polycyclic aromatic hydrocarbons (PAHs) in the environment necessitate effective remediation strategies. Hence, this study investigated the potential of purified Laccases, TlFLU1L and TpFLU12L, from two indigenous fungi Trichoderma lixii FLU1 (TlFLU1) and Talaromyces pinophilus FLU12 (TpFLU12), respectively for the oxidation and detoxification of anthracene. Anthracene was degraded with vmax values of 3.51 ± 0.06 mg/L/h and 3.44 ± 0.06 mg/L/h, and Km values of 173.2 ± 0.06 mg/L and 73.3 ± 0.07 mg/L by TlFLU1L and TpFLU12L, respectively. The addition of a mediator compound 2,2-azino-bis (3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) to the reaction system significantly increased the degradation of anthracene, with up to a 2.9-fold increase in vmax value and up to threefold decrease in Km values of TlFLU1L and TpFLU12L. The GC–MS analysis of the metabolites suggests that anthracene degradation follows one new pathway unique to the ABTS system—hydroxylation and carboxylation of C-1 and C-2 position of anthracene to form 3-hydroxy-2-naphthoic acid, before undergoing dioxygenation and side chain removal to form chromone which was later converted into benzoic acid and CO2. This pathway contrasts with the common dioxygenation route observed in the free Laccase system, which is observed in the second degradation pathways. Furthermore, toxicity tests using V. parahaemolyticus and HT-22 cells, respectively, demonstrated the non-toxic nature of Laccase-ABTS-mediated metabolites. Intriguingly, analysis of the expression level of Alzheimer’s related genes in HT-22 cells exposed to degradation products revealed no induction of neurotoxicity unlike untreated cells. These findings propose a paradigm shift for bioremediation by highlighting the Laccase-ABTS system as a promising green technology due to its efficiency with the discovery of a potentially less harmful degradation pathway, and the production of non-toxic metabolites.
On optimal three-impulse Earth–Moon transfers in a four-body model
Authors: Grossi Guido , Buonagura Carmine , Giordano Carmine , Topputo Francesco 
Published: June 2024

AbstractWithin the emerging age of lunar exploration, optimizing transfer trajectories is a fundamental measure toward achieving more economical and efficient lunar missions. This study addresses the possibility of reducing the fuel cost of two-impulse Earth–Moon transfers in a four-body model with the Earth, the Moon, and the Sun as primaries. Lawden’s primer vector theory is applied within this framework to derive a set of necessary conditions for a fuel-optimal trajectory. These conditions are used to identify which trajectories from an existing database could benefit from the insertion of an additional intermediate impulse. More than 10,000 three-impulse transfers are computed with a direct numerical optimization method. These solutions contribute to enriching the database of impulsive trajectories, useful to perform trade-off analyses. While the majority of trajectories exhibit only marginal improvements, a significant breakthrough emerges for transfers featuring an initial gravity assist at the Moon. Implementing a corrective maneuver after the lunar encounter yields substantial reductions in fuel costs.
Astrocyte-Specific Inhibition of the Primary Cilium Suppresses C3 Expression in Reactive Astrocyte
Authors: Muhamad Nor Atiqah , Masutani Kohei , Furukawa Shota , Yuri Shunsuke , Toriyama Michinori , Matsumoto Chuya , Itoh Seiya , Shinagawa Yuichiro , Isotani Ayako , Toriyama Manami , Itoh Hiroshi 
Published: June 2024

AbstractC3-positive reactive astrocytes play a neurotoxic role in various neurodegenerative diseases. However, the mechanisms controlling C3-positive reactive astrocyte induction are largely unknown. We found that the length of the primary cilium, a cellular organelle that receives extracellular signals was increased in C3-positive reactive astrocytes, and the loss or shortening of primary cilium decreased the count of C3-positive reactive astrocytes. Pharmacological experiments suggested that Ca2+ signalling may synergistically promote C3 expression in reactive astrocytes. Conditional knockout (cKO) mice that specifically inhibit primary cilium formation in astrocytes upon drug stimulation exhibited a reduction in the proportions of C3-positive reactive astrocytes and apoptotic cells in the brain even after the injection of lipopolysaccharide (LPS). Additionally, the novel object recognition (NOR) score observed in the cKO mice was higher than that observed in the neuroinflammation model mice. These results suggest that the primary cilium in astrocytes positively regulates C3 expression. We propose that regulating astrocyte-specific primary cilium signalling may be a novel strategy for the suppression of neuroinflammation.
Graphical Abstract
The primary cilium of astrocytes are required for the C3 expression in reactive astrocytes. Furthermore, the potentiation of calcium signalling appears to be involved in the promotion of C3 expression in reactive astrocytes.