bluuebunny/crossref_metadata_2025_split huggingface dataset:
EFFECT OF ESTRADIOL / NORETHINDRONE ACETATE ON 24-HOUR BLOOD PRESSURE PROFILE IN POSTMENOPAUSAL WOMEN
Authors: Stojanovic Milos , Ivovic Miomira , Gajic Milina Tancic , Miletic Marija , Marina Ljilja , Arizanovic Zorana , Boskovic Andjela , Pavlovic Natalija , Petkovic Tijana , Vujovic Svetlana 
Published: May 2024

Objective:
Framingham Heart Study found increased risk of cardiovascular events that occurs after menopause. Staessen found that menopause is associated with elevated blood pressure (BP), increased left ventricular wall thickness, decreased systolic performance, and decreased nocturnal BP fall. In the Italian population of SIMONA study, a significant increase in both systolic BP and diastolic BP was found in more than 18 000 Italian postmenopausal women, aged 46–59 years, compared to premenopausal and perimenopausal women. A growing body of evidence indicates that hormone replacement therapy (HRT) is beneficial in postmenopausal women. It is associated with symptomatic improvement: regulation of dysfunctional uterine bleeding, prevention of atrophic changes in the urogenital tract, a lower risk of osteoporosis and Alzheimer's disease, reduction of arterial stiffness, improvement in endothelium-dependent vasodilatation, a normalization of lipid profile, reduction of BP.

Design and method:
Design of the ongoing study in our Infertilty Center at the Institute of Endocrinology, we examined the effects of estradiol / norethindrone acetate on 24-h ambulatory blood pressure (ABPM) in 221 hypertensive postmenopausal women (HPMW, 51+/-2 [mean+/-SE] years, BMI 22.72±2.87kg/m2). Validated, Meditech ABPM 05 ambulatory blood pressure monitor was used to obtain 24-h BP before and after six months therapy with estradiol / norethindrone acetate. Most women did not change antihypertensive treatment during the study.

Results:
After six months on HRT BP was lowered by an average of 1 mmHg systolic and 2 mmHg diastolic per day and per night BP was lowered by an average of 2 mmHg systolic and 1 mmHg diastolic. BP reductions were not significantly lower with regard to systolic or diastolic BP before initiation of HRT nor to action on day and night-time BP.

Conclusions:
BP reduction in HPMW after six months receiving estradiol / norethindrone acetate may lower the physicians concern that hypertension might worsen if they prescribe estradiol / norethindrone acetate. We propose a large international prospective study to confirm that an appropriate HRT in postmenopausal women lowers ABPM values and normalize a blunted nocturnal BP decline.
FEATURES OF BLOOD PRESSURE DAILY PROFILE IN HYPERTENSIVE PATIENTS WITH TYPE 2 DIABETES
Authors: Srojidinova Nigora , Saidakbarova Feruza , Duysenbayeva Aziza 
Published: May 2024

Objective:
To study the blood pressure daily profile in patients with hypertension (HNT) depending on the presence of type 2 diabetes mellitus (DM2).

Design and method:
We observed 412 hypertensive patients. The ambulatory BP monitoring (ABPM) was recorded with Medicom-combi device (Russia) using the oscillometric method. Statistical analysis was performed using the SPSS 24.0 software package.

Results:
Patients were divided into 2 groups: the first group consisted of hypertensive patients with DM2 (n = 121), and the second group consisted of hypertensive patients without DM2 (n = 291). Groups were comparable in office SBP: 133.7±20.19 mm Hg and 134.42±19.74 mm Hg, respectively. However, DBP was significantly higher in patients with DM2: 84.08±10.89 mmHg vs. 82.96±9.34 mmHg, p=0.02. Analysis showed that patients with DM2 had significantly higher average daily SBP (122.89± 13.38 vs. 119.467± 14.02 mmHg, respectively, p = 0.023) and DBP (71.401± 9.4 vs. 70.47± 7.40 mmHg, respectively, p = 0.021) compared to patients without DM2. Mean daily SBP (124.26±13.46 vs. 121.4±12.72 mmHg, respectively, p = 0.046) and mean daily DBP (29.19±25.76 vs. 24.11±27.22 mmHg, respectively, p = 0.012) were also higher in patients with DM2. SBP and DBP variability didn’t differ between the groups. Moreover, the load index of SBP in the daytime and nighttime was higher in the second group. Load index of daytime SBP –19.00±25.15% vs 12.89±19.49%, respectively, p=0.009 and load index of nighttime SBP - 35.03±34.78%–vs 24.71±30.08%, respectively, p=0.003. Nocturnal fall of SBP was deficient in-group with DM2 in comparison with one without DM2: nocturnal fall of SBP was 3.72±6.44% vs. 6.17±10.62%, p = 0.019, but nocturnal fall of DBP did not differ: 5.10±8.33% vs. 6.72±8.21%, respectively, p = 0.069. Dipping status was significantly lower in patients with DM2 (9.6 ±5.7%, x2 = 8.91, p = 0.03). The number of non-dippers (63.5% vs. 55%) and night-pickers (26.3% vs. 16.8%) was also higher in the second group without statistical significance. The number of over-dippers in both groups didn’t differ.

Conclusions:
Hypertensive patients with DM2 have more disturbances in the daily BP profile, which contribute to an increased risk of developing cardiovascular complications.
THE AGREEMENT BETWEEN HEART RATE MEASURED USING UNATTENDED AUTOMATED BLOOD PRESSURE MEASUREMENT AND OTHER METHODS OF BLOOD PRESSURE ASSESSMENT
Authors: Sobieraj Piotr , Lesniewski Mateusz , Sinski Maciej , Lewandowski Jacek 
Published: May 2024

Objective:
The trial was aimed to assess the agreement between resting heart rate (HR) measured using unattended automatic (uAOBPM) and office (OBPM) or 24-h ambulatory blood pressure measurement (ABPM).

Design and method:
A total of 110 participants were included in the study. All underwent measurements using uAOBPM, OBPM, and ABPM. Results of ABPM were analysed in 3 periods: 24h (24h-ABPM), day activity (aABPM) and night rest (nABPM). Continuous variables were presented as means with standard deviation, while categorical variables were expressed as numbers and percentages. The comparisons were conducted using the paired t-test and Bland-Altman statistics.

Results:
Mean age was 56.5 ± 18.3 years. Mean HR measured using uAOBPM (70.8 ± 12.5 b.p.m.) was lower than measured using OBPM (72.8 ± 12.6 b.p.m., p<0.001), higher than measured using 24h-ABPM (67.5 ± 10.2 b.p.m., p<0.001) or nABPM (62 ± 8.7 b.p.m., p<0.001). There was no difference between HR measured using uAOBPM and aABPM (70.3 ± 11.2 b.p.m., p=0.5).
Bland-Altman analysis showed smallest bias when HR was measured using uAOBPM and ABPM 0.4 (95% CI:-0.8 to 1.6) b.p.m. and -2 (95% CI:- 2.8 to -1.3) b.p.m., though the range between lower and upper limits of agreement was higher when uAOBPM has been compared with aABPM and not with OBPM. The largest bias between limits of agreement was found when uAOBPM was compared with nABPM 8.8 (95% CI:7.2 to 10.4) b.p.m. Also the largest range between lower and upper limits of agreement was when agreement between uAOBPM and nABPM was assessed.
The results of Bland-Altman analysis is presented using Figure 1.

Conclusions:
The best agreement between HR measurements was observed when uAOBPM was compared with OBPM or aABPM.
SURVEY INDICATES GREATER PATIENT PREFERENCE FOR AKTIIA'S CUFFLESS MONITOR OVER TRADITIONAL AMBULATORY BLOOD PRESSURE MONITOR IN A CARDIAC REHABILITATION PROGRAM
Authors: De Almeida Tiago Paggi , Perruchoud David , Alexandre Jérémy , Vermare Pascale , Sola Josep , Shah Jay , Marques Luisa , Pellaton Cyril 
Published: May 2024

Objective:
Cuffless blood pressure (BP) monitors have the potential to improve hypertension management and facilitate remote BP monitoring. The success and long-term adoption of these devices will significantly depend on patient preferences and their perceptions of using such technology. In the present work, we report patients’ preferences regarding a continuous cuffless BP monitor and cuff-based ambulatory BP monitoring (ABPM) during a 12-week cardiac rehabilitation (CR) program.

Design and method:
63 subjects (NCT04548986, mean age 53.1±7.2 years, 21.2% female, arm circumference 29.0±2.5 cm) were enrolled in a 12-week CR program at RHNE – Réseau Hospitalier Neuchâtelois, Switzerland. Subjects wore a cuffless BP monitor (Aktiia SA, Switzerland) during the entire CR program, and conducted 24-h ABPM (Dyasis 3, Novacor, France) during the first and last days of CR. The analysis was conducted on experience surveys completed by subjects who successfully finished the CR program.

Results:
57 subjects completed the CR program and filled the survey at the end of the program (Figure 1). From an open question for 3 adjectives regarding experience with the Aktiia monitor, the most cited terms were “discreet” (53% of the subjects), “light” (47%) and “comfortable” (28%), with more than 15% of the subjects describing it as “practical” and “pleasant”. For ABPM, the most cited terms were “bulky” (41%), “noisy” (26%) and “uncomfortable” (17%), with approximately 10% of subjects describing it as “embarrassing”, “unpleasant” and “heavy”. Nearly all subjects felt no discomfort when using the Aktiia monitor, and almost 90% of the subjects would repeat night measurements with Aktiia. Subjects were equally confident in the precision for both devices, and few subjects reported any disruption in their daily activities due to wearing Aktiia's bracelet.

Conclusions:
Among patients who used both the Akiia bracelet and ABPM and during the 12-weeks CR program, the vast majority found the cuffless monitor more convenient, more comfortable and with a similar perception of performance compared to ABPM. The results suggest that cuffless BP devices may facilitate continual 24-h BP monitoring compared to an ABPM setup and enhance patients’ adherence to BP monitoring.
CURRENT STATUS OF USE OF VALIDATED DEVICES FOR HOME BLOOD PRESSURE MONITORING AMONG PATIENTS WITH HYPERTENSION
Authors: Lee Ji Eun , Yoo Seungwon , Kim Dae-Young , Shin Sung-Hee , Na Jin Oh , Shin Jinho , Park Kiho , Lee Eun Mi 
Published: May 2024

Objective:
Hypertension is the most important modifiable risk factor for cardiovascular diseases. Nevertheless, the control rate (<140/90 mmHg) in hypertensive patients is lower than 50% in Korea. The implementation of Home Blood Pressure Monitoring (HBPM) improves the diagnosis and treatment of hypertension. Current clinical guidelines advocate the use of validated HBPM devices. However, there are few studies about the current use of validated devices for HBPM. We aimed to investigate the present status of use of validated HBPM devices in real-world hypertensive patients.

Design and method:
This study was conducted on Korean hypertensive patients using CareforMe®, a smartphone healthcare application which allows the patients to record their HBPM data. HBPM devices included upper-arm and wrist devices. According to the STRIDE BP, validated devices included 3 categories: Preferred devices (published within the last 10 years and used a recently established protocol of device validation), Validated devices (have passed established validation procedures that have been checked and approved by the STRIDE BP Scientific Advisory Board), and Equivalent devices (equivalent to a device that has fulfilled the criteria for validated devices).

Results:
From May 2021 through December 2023, a total of 2,539 patients inputted model numbers of their HBPM devices. 112 devices and 32 different manufacturers were identified. 96.9% (n=2,461) of patients used upper-arm devices and 3.1% (n=78) used wrist devices. Out of 112 devices, 12 Preferred upper-arm devices, 5 Validated upper-arm devices, 5 Equivalent devices and 2 Validated wrist devices were identified. Only 17.8% (n=453) our of 2,539 patients were using Preferred HBPM devices, 2.3% (n=58) used Validated upper-arm devices, and 25.7% (n=652) were using Equivalent devices. Among patients using wrist devices, 17.9% (n=14) used validated devices.

Conclusions:
To the best of our knowledge, this is the first study to analyze the current status of use of validated HBPM devices among hypertensive patients in Korea. 96.9% patients used upper-arm devices, and among them, only 47.3% patients were using validated devices. Our results proposed the urgent need of patient education on accurate HBPM and public accessibility on validated devices to better management of patients with hypertension.
MAY MEASURE MONTH 2022 IN ITALY: RESULTS OF A NATIONWIDE SURVEY
Authors: Del Pinto Rita , Rosei Claudia Agabiti , Borghi Claudio , Cottone Santina , Fabris Bruno , Giannattasio Cristina , Minuz Pietro , Mulè Giuseppe , Nazzaro Pietro , Parati Gianfranco , Rattazzi Marcello , Sarzani Riccardo , Veglio Franco , Vulpis Vito , De Giorgi Giuseppe Antonio , Di Guardo Antonino , Dugnani Maurizio , Saladini Francesca , Ferri Claudio , Muiesan Maria Lorenza , Serio Leandra 
Published: May 2024

Objective:
By affecting approximately 45% of the world's population, hypertension is the main risk factor for cardiovascular diseases (CVD). Of note, only half of hypertensive patients manage to have good blood pressure (BP) control. Relevant reasons for the persistence of uncontrolled BP during treatment are lack of compliance on the patients’ side, and therapeutic inertia on physicians’ side.

Design and method:
During the global BP screening campaign “May Measure Month” (MMM) (May 1st to July 31st, 2022), a nationwide, cross-sectional, opportunistic study endorsed by the Italian Society of Hypertension was conducted on volunteer adults >= 18 years to raise awareness of the health issues surrounding high BP. A questionnaire on demographic/clinical features and questions on the use of fixed-dose single-pills for the treatment of hypertension was administered. BP was measured with standard procedures.

Results:
A total of 1612 participants (mean age 60.0±15.41 years; 44.7% women) were enrolled. Their mean BP was 128.5±18.1/77.1±10.4 mmHg. About one in two participants was sedentary, or overweight/obese, or hypertensive. 55.5% individuals with complete BP assessment had uncontrolled hypertension; not being on a fixed-dose combination of antihypertensive drugs and not measuring their BP at home were common features in this setting. Self-reported adherence to BP medications was similar between individuals with controlled and uncontrolled BP (95% vs 95.5%).

Conclusions:
This survey identified a certain degree of therapeutic inertia and poor patients’ involvement in the therapeutic process and its monitoring in the examined population, underlining the importance of prevention campaigns to increase risk factors awareness to reduce CV risk.
A LINEAR RELATIONSHIP OF ANKLE-BRACHIAL SYSTOLIC BLOOD PRESSURE INDEX FOR COGNITIVE FUNCTION DECLINE AMONG OLDER ADULTS WITHOUT PERIPHERAL ARTERY DISEASE: THE HALST STUDY
Authors: Chuang Shao-YUAN , Chung Ren-Hua , Lai Chia-Hung , Liu Wen-Ling , Chang Hsing-Yi , Hsiun Chao Agnes , Chuang Shu-Chun , Wu I-Chien , Hsu Chih-Cheng 
Published: May 2024

Objective:
Peripheral artery disease is associated with higher cognitive impairment. However, the association between ankle-brachial index (ABI) and cognitive function decline remains unclear. We aimed to investigate the association of ABI with cognitive function decline among older adults.

Design and method:
A total of 3662 people aged more than 55 years old (Men: 1702 and Women: 1960) without peripheral artery disease (0.9 < ABI < 1.4) from the Healthy Aging Longitudinal Study in Taiwan was evaluated for cognitive function using MMSE in baseline (2009∼2013) and 2nd wave (2014∼2019).
Ankle-brachial index was measured by the ratio of supine ankle and brachial systolic blood pressure. Cognitive function decline was calculated by MMSE at baseline mines MMSE at 2nd wave. Linear regression was used to investigate the associations of baseline ABI with future cognitive function and cognitive function decline.

Results:
The average of MMSE at baseline, at 2nd wave and the change during the follow-period were 26.9 (standard deviation[s.d.]=3.17), 25.5 (s.d.=4.28) and -1.42 (s.d.=2.94), respectively. Baseline left-ABI (beta = 1.50, p=0.0060) was positively associated with future MMSE, independent of age, gender, education and baseline MMSE, but right-ABI (Beta=0.80, p=0.1517) was not. Furthermore, the MMSE score change (from baseline to 2nd wave) was -0.36 (p=0.0084) for the 1st (Lowest), -0.25 (p=0.00736) for the 2nd, and -0.211 (p=0.1296) for the 3rd Left-ABI, compared to the referent group (highest) of Left-ABI, respectively, in the multivariable model.

Conclusions:
Baseline higher ankle-brachial index was positively associated with future cognitive performance and with a lower decline rate of cognitive function among older adults.
PREVALENCE OF MASKED HYPERTENSION IN ATTENDED VS. UNATTENDED OFFICE BLOOD PRESSURE MEASUREMENT
Authors: Bertram Sebastian , Bauer Frederic , Shadi Rohni , Rieckmann Sonja , Seidel Maximilian , Doevelaar Adrian , Seibert Felix , Babel Nina , Westhoff Timm 
Published: May 2024

Objective:
There is a controversial debate, whether unattended blood pressure (BP) measurement should be regarded as the new gold standard of office BP measurement, since it eliminates the white-coat effect and reduces external influences on the patient. On the other hand, it might underestimate real life BP. The present study compares the prevalence of masked hypertension using attended vs. unattended office BP measurement.

Design and method:
We performed a cross-sectional study in 213 patients in a general practioners outpatient clinic and compared attended and unattended office BP with 24h-ambulatory blood pressure monitoring (24h-ABPM). Masked hypertension was defined as pressure >=135/85mmHg in daytime ABPM with office systolic BP<140/90mmHg.

Results:
Median attended and unattended office BPs were 140/86 and 134/80mmHg with median 24h-BP of 129/79mmHg and daytime-ABP of 133/82mmHg. The number of patients with masked hypertension was 45/213 (21.2%) using unattended and 23/213 (10.8%) using attended office BP measurement (p<0.0001). Bland-Altman analysis revealed biases of 7.4mmHg systolic and 6.2mmHg diastolic between the attended vs. unattended office BP and biases of 2 systolic and -1.7mmHg diastolic between unattended office BP and daytime ambulatory BP. In linear regression analysis an unattended office BP of 134mmHg corresponded to 140mmHg in attended BP measurement. Using a cut-off of 135/85mmHg instead of 140/90mmHg in unattended office BP measurement the rate of masked hypertension was 26/213 (12.2%).

Conclusions:
Thus, unattended office BP measurement results in a substantial increase in the prevalence of masked hypertension using the traditional definition of hypertension. The present findings suggest that it might be reasonable to use a definition of 135/85mmHg.
VALIDATION OF A NOVEL PROFESSIONAL AUTOMATED AUSCULTATORY BLOOD PRESSURE MONITOR KOROT V2 DOCTOR IN GENERAL POPULATION ACCORDING TO THE AAMI/ESH/ISO UNIVERSAL STANDARD
Authors: Theodosiadi Aikaterini , Menti Ariadni , Ntousopoulos Vasileios , Ntineri Angeliki , Stathopoulou Panagiota , Kyriakoulis Konstantinos , Kollias Anastasios , Stergiou George 
Published: May 2024

Objective:
A novel automated auscultatory upper arm-cuff blood pressure (BP) monitor KOROT V2 Doctor was developed for professional use. This device is equipped with an electronic stethoscope integrated into the cuff to enable recording of Korotkoff sounds. These auditory signals are graphically displayed during the deflation process, offering to the healthcare professionals a visual tool for assessing the quality of each automated reading. The device was validated according to the Association for the Advancement of Medical Instrumentation/European Society of Hypertension/International Organization for Standardization (AAMI/ESH/ISO) Universal Standard (ISO 81060-2:2018) and its Amendment 1.2020-01.

Design and method:
Participants were recruited to fulfil the age, sex, BP, arm circumference and cuff distribution criteria of the Universal Standard and its Amendment in a general population using the same arm sequential measurement method. Three cuffs of the test device were tested for arm circumference 23-28, 28-35 and 33-42 cm.

Results:
Data from 85 individuals were analyzed (mean age 56.4±16.0 [SD] years, 50 men, arm circumference 23-42 cm). For validation Criterion 1, the mean difference ±SD between the test device and reference BP readings (N=255) was -1.3±6.0/1.5±5.0 mmHg (systolic/diastolic; threshold <= 5±8 mmHg). For Criterion 2, the SD of the averaged BP differences per individual (N=85) was 4.61/3.48 mmHg (systolic/diastolic; threshold <= 6.82/6.78 mmHg).

Conclusions:
The KOROT V2 Doctor electronic device developed for professional use, which provides automated auscultatory measurements with visual display of the Korotkoff sounds, comfortably fulfilled all the requirements of the AAMI/ESH/ISO Universal Standard (ISO 81060-2:2018) in a general population and can be recommended for clinical use. This novel device offers potential additional advantages for clinical practice, as it simulates the gold standard manual auscultatory method and allows healthcare professionals to visually assess Korotkoff sounds during each measurement, allowing the rejection of poor-quality readings.
RELATIONSHIP OF PARAMETERS OF CENTRAL HEMODYNAMICS AND ARTERIAL STIFFNESS WITH COGNITIVE FUNCTIONS IN PATIENTS WITH ESSENTIAL HYPERTENSION
Authors: Yusupova Khafiza , Abdullaeva Guzal , Khamidullaeva Gulnoz , Mashkurova Zaringiz , Masharipov Shukhrat 
Published: May 2024

Objective:
To conduct a correlation analysis of central hemodynamics and arterial stiffness parameters with cognitive functions in patients with essential hypertension (EH).

Design and method:
The study included 111 male and female patients with grades I–III AH according to the classification (ESC/ESH, 2018). The average age of the patients was 54.6±10.8 years, the average duration of AH was 8.8±5.52 years. The state of arterial stiffness was assessed by applanation tonometry using the SphygmoCor apparatus (AtCor Medical, Australia). Cognitive functions were assessed using neuro-psychological tests: the Mini-Cog test (drawing a clock, reproducing words) and the Montreal Cognitive Assessment Scale (MOCA).

Results:
The correlation analysis between the parameters of central hemodynamics and arterial stiffness revealed a negative correlation between the pulse wave velocity (PWV) and the severity of cognitive impairment, in particular, with the overall Mini-Cog score (R=-0.24, p=0.01), as well as central pulse pressure (CPP) with a total score on the Mini-Cog test (R=-0.27, p=0.007).

Conclusions:
Thus, an increase in pulse wave velocity and central pulse pressure correlates with the severity of cognitive impairment in EH patients.