bluuebunny/crossref_metadata_2025_split huggingface dataset:
Influence of Selective Laser Trabeculoplasty on 24-Hour Diurnal Intraocular Pressure Fluctuation in Primary Open-Angle Glaucoma: A Pilot Study
Authors: Kóthy Péter , Tóth Márta , Holló Gábor 
Published: May 2010

BACKGROUND AND OBJECTIVE:
To investigate the influence of selective laser trabeculoplasty on mean diurnal intraocular pressure (IOP) and diurnal IOP fluctuation in primary open-angle glaucoma.

PATIENTS AND METHODS:
After washout from intraocular pressure–lowering drugs, a baseline diurnal IOP curve was obtained for 26 eyes of 13 patients before selective laser trabeculoplasty. The IOP curve was repeated at 3 and 6 months.

RESULTS:

In five eyes, office time (8:00 a.m. to 12:00 p.m.) IOP decreased by 20% or more. No similar decrease was seen in mean diurnal IOP in any case. IOP-lowering drugs were required for 11 eyes before the 3-month visit. Baseline diurnal IOP was higher for these eyes than for the others (
P
= .002). Compared with baseline values, a significant decrease was seen in mean IOP at the 6-month visit (
P
= .017) and in IOP fluctuation at both visits (
P
< .001 and
P
= .004, respectively) for the eyes without drug treatment.

CONCLUSION:
Although no eyes showed mean diurnal IOP reduction of 20% or more, selective laser trabeculoplasty resulted in a significant decrease in the amplitude of diurnal IOP fluctuation.

[Ophthalmic Surg Lasers Imaging 2010;41:342–347.]
Ig-Free Light Chains Play a Crucial Role in Murine Mast Cell-Dependent Colitis and Are Associated with Human Inflammatory Bowel Diseases
Authors: Rijnierse Anneke , Redegeld Frank A. , Blokhuis Bart R. , Van der Heijden Maurice W. , Te Velde Anje A. , Pronk Inge , Hommes Daniel W. , Nijkamp Frans P. , Koster Andries S. , Kraneveld Aletta D. 
Published: May 2010

AbstractTraditionally, mast cells were regarded as key cells orchestrating type I hypersensitivity responses. However, it is now recognized that mast cells are widely involved in nonallergic (non-IgE) chronic diseases. Also, in inflammatory bowel disease (IBD), a disease not associated with increased IgE concentrations, clear signs of activation of mast cells have been found. In this study, we investigated if Ig-free L chain-induced hypersensitivity-like responses through activation of mast cells could contribute to the pathophysiology of IBD. As a mast cell-dependent model for IBD, mice were skin-sensitized with dinitrofluorobenzene followed by intrarectal application of the hapten. In this murine IBD model, F991 prevented mast cell activation and also abrogated the development of diarrhea, cellular infiltration, and colonic lymphoid follicle hyperplasia. Furthermore, passive immunization with Ag-specific Ig-free L chains (IgLCs) and subsequent rectal hapten challenge elicited local mast cell activation and increased vascular permeability in the colon of mice. Clinical support is provided by the observation that serum concentrations of IgLCs of patients suffering from Crohn’s disease are greatly increased. Moreover, increased presence of IgLCs was evident in tissue specimens from colon and ileum tissue of patients with IBD. Our data suggest that IgLCs may play a role in the pathogenesis of IBD, which provides novel therapeutic means to prevent or ameliorate the adverse gastrointestinal manifestations of IBD.
IL-7–Dependent B Lymphocytes Are Essential for the Anti-polysaccharide Response and Protective Immunity toStreptococcus pneumoniae
Authors: Shriner Anne K. , Liu Hongqi , Sun Guizhi , Guimond Martin , Alugupalli Kishore R. 
Published: May 2010

AbstractYoung children are impaired in their response to T cell-independent (TI) Ags, such as pneumococcal polysaccharide (PPS). B lymphopoeisis early in life is IL-7 independent, whereas in adults it is IL-7 dependent. Therefore, we hypothesized that IL-7–driven B lymphopoiesis plays a critical role in promoting Ab responses to TI Ags. Young but not adult mice are impaired in responses to PPS vaccination and to 4-hydroxy-3-nitrophenyl-acetyl-Ficoll, a widely studied model TI Ag, and B1b cells generate Ab responses to these Ags. In this paper, we show that, despite having B1b, B1a, and MZ B cells—all of which are involved in TI responses—young wild-type or adult mice deficient either in IL-7 or in IL-7Rα are severely impaired in anti-PPS responses and do not survive Streptococcus pneumoniae challenge, indicating IL-7–dependent B cells are required for TI immunity. Consistent with this, PPS immunization induced a robust TI response in young IL-7 transgenic mice that was comparable to adult wild-type responses. Moreover, immunized young or adult IL-7 transgenic mice were completely resistant to S. pneumoniae challenge. Our data indicate that activating the IL-7 signaling pathway could restore impaired TI responses in the young.
Distinct Roles of Adenylyl Cyclase VII in Regulating the Immune Responses in Mice
Authors: Duan Biyan , Davis Richard , Sadat Eva L. , Collins Julie , Sternweis Paul C. , Yuan Dorothy , Jiang Lily I. 
Published: May 2010

Abstract
The second messenger cAMP plays a critical role in regulating immune responses. Although well known for its immunosuppressive effect, cAMP is also required for the development of optimal immune responses. Thus, the regulation of this second messenger needs to be finely tuned and well balanced in a context dependent manner. To further understand the role of cAMP synthesis in the functions of the immune system, we focus on a specific adenylyl cyclase (AC) isoform, AC VII (AC7), which is highly expressed in the immune system. We show that mice deficient of AC7 are hypersensitive to LPS-induced endotoxic shock. Macrophages from AC7-deficient mice produce more of the proinflammatory cytokine, TNF-α, in response to LPS. The inability to generate intracellular cAMP response to serum factors, such as lysophosphatidic acid, is a potential cause for this phenotype. Thus, AC7 functions to control the extent of immune responses toward bacterial infection. However, it is also required for the optimal functions of B and T cells during adaptive immune responses. AC7 is the major isoform that regulates cAMP synthesis in both B and T cells. AC7-deficient mice display compromised Ab responses toward both T cell-independent and T cell-dependent Ags. The generation of memory T cells is also reduced. These results are the first to ascribe specific functions to an AC isoform in the immune system and emphasize the importance of cAMP synthesis by this isoform in shaping the immune responses.
BADA: An advanced aircraft performance model for present and future ATM systems
Authors: Nuic Angela , Poles Damir , Mouillet Vincent 
Published: May 2010

AbstractThis paper gives an overview of Base of Aircraft Data (BADA), an Aircraft Performance Model developed and maintained by EUROCONTROL. BADA is based on a kinetic approach to aircraft performance modelling, which models aircraft forces. The intended use of BADA is trajectory simulation and prediction in Air Traffic Management (ATM) Research and Development and strategic planning in ground ATM operations. BADA is used for various ATM‐related studies which require information on aircraft performances. The paper provides details on the existing BADA family 3 model and the latest achievements in the development of the new BADA family 4 model. Several examples of the applications of using BADA are provided, together with information on how to obtain access to BADA. Copyright © 2010 EUROCONTROL. All rights reserved.
Self‐Oscillating Gels Driven by the Belousov–Zhabotinsky Reaction as Novel Smart Materials
Authors: Yoshida Ryo 
Published: May 2010

AbstractSo far stimuli‐responsive polymer gels and their application to smart materials have been widely studied; this research has contributed to progress in gel science and engineering. For their development as a novel biomimetic polymer, studies of polymers with an autonomous self‐oscillating function have been carried out since the first reports in 1996. The development of novel self‐oscillating polymers and gels have been successful utilizing the oscillating reaction, called the Belousov–Zhabotinsky (BZ) reaction, which is recognized as a chemical model for understanding several autonomous phenomena in biological systems. The self‐oscillating polymer is composed of a poly(N‐isopropylacrylamide) network in which the catalyst for the BZ reaction is covalently immobilized. In the presence of the reactants, the polymer undergoes spontaneous cyclic soluble–insoluble changes or swelling–deswelling changes (in the case of gel) without any on–off switching of external stimuli. Potential applications of the self‐socillating polymers and gels include several kinds of functional material systems, such as biomimetic actuators and mass transport surface.
The role of collaborative partnerships in industry innovation: lessons from New Zealand's dairy sector
Authors: Hartwich Frank , Negro Carlos 
Published: May 2010

AbstractThis study analyzes patterns of collaboration in research and development (R&D) for innovation in New Zealand's dairy industry. Based on a survey of agents contributing to industry innovation, it analyzes existing formal and informal partnerships between R&D organizations and the productive sector and the funding schemes that support such partnerships. The findings suggest that New Zealand's dairy innovation system depends on the capacity of a small number of public and industry agents. Government and industry organizations support innovation initiatives through various funding schemes that do not explicitly foster collaboration, and mechanisms that support informal collaboration are underdeveloped. [EconLit citations: O32, Q13, Q16]. © 2010 Wiley Periodicals, Inc.
Phosphatidylserine exposure and other apoptotic‐like events in Bernard‐Soulier syndrome platelets
Authors: Rand Margaret L. , Wang Hong , Bang K.W. Annie , Teitel Jerome M. , Blanchette Victor S. , Freedman John , Nurden Alan T. 
Published: May 2010

AbstractIn the Bernard‐Soulier syndrome (BSS), the giant platelets are said to have increased phosphatidylserine (PS) surface exposure in the resting state and shortened survival in the circulation. When normal platelets are activated, they undergo many biochemical and morphological changes, some of which are apoptotic. Herein, we investigated apoptotic‐like events in BSS platelets upon activation, specifically, PS exposure, microparticle (MP) formation, cell shrinkage, and loss of mitochondrial inner membrane potential (ΔΨm). Platelets from two unrelated BSS patients were examined in whole blood; agonists used were collagen, thrombin, PAR1‐ or PAR4‐activating peptides (APs), or combinations of collagen with thrombin, and the PAR‐APs. Flow cytometry was used to measure PS exposure (annexin A5 binding), platelet‐derived MPs (forward scatter; events <0.75 μm size), and ΔΨm (TMRM fluorescence). PS exposure was increased on resting and activated BSS platelets, and this was independent of the platelet size. MP formation by BSS platelets was generally enhanced. Cell shrinkage occurred on activation to form smaller, PS‐exposing platelets in BSS and controls. A proportion of PS‐exposing BSS and control platelets exhibited ΔΨm loss, but unlike controls, there was also loss of ΔΨm in the BSS platelets not exposing PS. Thus, BSS platelets undergo apoptotic‐like events upon activation, with PS exposure and MP formation being enhanced. These events may play a role in the shortened survival in BSS, as well as affecting thrombin generation. Am. J. Hematol. 85:584–592, 2010. © 2010 Wiley‐Liss, Inc.
Psychiatric and behavioral manifestations of lysosomal storage disorders
Authors: Staretz‐Chacham Orna , Choi Jae Hyuk , Wakabayashi Kazuyo , Lopez Grisel , Sidransky Ellen 
Published: May 2010

AbstractThe different lysosomal storage disorders (LSDs) manifest with a wide spectrum of clinical presentations. Most of these disorders are typically diagnosed early in life, due to the severity of the associated phenotypes. However, it is important to appreciate that some of the LSDs present later in adolescence or adulthood. The diverse findings triggering the initial diagnosis, as well as the range of manifestations arising later during the disease course, contribute to the complexity of these issues. Clinical presentations occurring at a more advanced age, especially psychiatric and behavioral manifestations, can be overlooked or misdiagnosed. This review describes different psychiatric and behavioral manifestations encountered in individuals with LSDs, including psychosis, schizophrenia, mood disorders, aggressiveness, early‐onset dementia, and conduct disorder. Twelve different disorders are presented, including descriptions of their associated biochemical abnormalities, clinical presentations, pathology, epidemiology, and genetics. In addition, discussions of neurocognitive, behavioral, and psychiatric findings are outlined for each disorder. A greater awareness of these features may help to reduce missed diagnoses, to avoid unnecessary, invasive and expensive testing, and to facilitate an earlier detection of these rare disorders. Earlier diagnosis can enable the implementation of appropriate interventions and improve genetic counseling. © 2010 Wiley‐Liss, Inc.
Earliest colobine skeletons from Nakali, Kenya
Authors: Nakatsukasa Masato , Mbua Emma , Sawada Yoshihiro , Sakai Tetsuya , Nakaya Hideo , Yano Wataru , Kunimatsu Yutaka 
Published: May 2010

AbstractOld World monkeys represent one of the most successful adaptive radiations of modern primates, but a sparse fossil record has limited our knowledge about the early evolution of this clade. We report the discovery of two partial skeletons of an early colobine monkey (Microcolobus) from the Nakali Formation (9.8–9.9 Ma) in Kenya that share postcranial synapomorphies with extant colobines in relation to arboreality such as mediolaterally wide distal humeral joint, globular humeral capitulum, distinctly angled zona conoidea, reduced medial trochlear keel, long medial epicondyle with weak retroflexion, narrow and tall olecranon, posteriorly dislocated fovea on the radial head, low projection of the femoral greater trochanter, wide talar head with a greater rotation, and proximodistally short cuboid and ectocuneiform. Microcolobus in Nakali clearly differs from the stem cercopithecoid Victoriapithecus regarding these features, as Victoriapithecus is postcranially similar to extant small‐sized terrestrial cercopithecines. However, degeneration of the thumb, a hallmark of modern colobines, is not observed, suggesting that this was a late event in colobine evolution. This discovery contradicts the prevailing hypothesis that the forest invasion by cercopithecids first occurred in the Plio‐Pleistocene, and shows that this event occurred by the late Miocene at a time when ape diversity declined. Am J Phys Anthropol 143:365‐382, 2010. © 2010 Wiley‐Liss, Inc.
CuI‐catalyzed homocoupling of terminal alkynes to 1,3‐diynes
Authors: Yin Kun , Li Chun‐Ju , Li Jian , Jia Xue‐Shun 
Published: May 2010

AbstractA simple and efficient protocol for CuI‐catalyzed oxidative homocoupling reaction of terminal alkynes to symmetrical 1,4‐disubstituted 1,3‐diynes was reported. The reaction can be carried out in the open air, using NaOAc as a base in the absence of any other additives. A variety of terminal alkynes were converted to the corresponding 1.3‐diynes in good to excellent yields without any side product formation. Copyright © 2010 John Wiley & Sons, Ltd.
Use of chitosan for removal of bisphenol A and bisphenol derivatives through tyrosinase‐catalyzed quinone oxidation
Authors: Suzuki Mizuho , Sugiyama Tatsuki , Musashi Eriko , Kobiyama Yuko , Kashiwada Ayumi , Matsuda Kiyomi , Yamada Kazunori 
Published: May 2010

AbstractIn this study, the availability of chitosan was systematically investigated for removal of bisphenol A (BPA, 2,2‐bis(hydroxyphenyl)propane) through the tyrosinase‐catalyzed quinone oxidation and subsequent quinone adsorption on chitosan beads. In particular, the process parameters, such as the hydrogen peroxide (H2O2)‐to‐BPA ratio, pH value, temperature, and tyrosinase dose, were discussed in detail for the enzymatic quinone oxidation. Tyrosinase‐catalyzed quinone oxidation of BPA was effectively enhanced by adding H2O2 and the optimum conditions for BPA at 0.3 mM were determined to be pH 7.0 and 40°C in the presence of H2O2 at 0.3 mM ([H2O2]/[BPA] = 1.0). Removal of BPA from aqueous solutions was accomplished by adsorption of enzymatically generated quinone derivatives on chitosan beads. The use of chitosan in the form of beads was found to be more effective because heterogeneous removal of BPA with chitosan beads was much faster than homogeneous removal of BPA with chitosan solutions, and the removal efficiency was enhanced by increasing the amount of chitosan beads dispersed in the BPA solutions and BPA was completely removed by quinone adsorption in the presence of chitosan beads more than 0.10 cm3/cm3. In addition, a variety of bisphenol derivatives were completely or effectively removed by the procedure constructed in this study, although the enzyme dose or the amount of chitosan beads was further increased as necessary for some of the bisphenol derivatives used. © 2010 Wiley Periodicals, Inc. J Appl Polym Sci, 2010
Correlation among powder morphology, compactability, and mechanical properties of consolidated nascent UHMWPE
Authors: Michler G. H. , Seydewitz V. , Buschnakowski M. , Myasnikowa L. P. , Ivan'kova E. M. , Marikhin V. A. , Boiko Y. M. , Goerlitz S. 
Published: May 2010

AbstractThe influence of the catalytic system and synthesis conditions on the reactor powder morphology and the molecular packing in the nascent UHMWPE is studied with the help of various electron microscopic methods. The potentiality of different morphologies for producing strong consolidated material by sintering at temperature lower than the melting temperature is considered. It is shown that the small catalytic particles of colloidal sizes (reactor powders of M‐series) produce homogeneous broccoli type morphology consisting of small nodules with the sizes less than 0.2–0.5 μm, which in turn, comprise crystalline domains and disordered regions. Comparison analysis of transmission electron microscopic data with the DSC and NMR results enabled to conclude that the disordered regions are predominantly comprised of tie molecules with low degree of coiling, taut tie molecules, and a number of tight folds. This type of morphology best fits for compaction and sintering. Reactor powder morphology arising upon synthesis lab‐scale and commercial UHMWPE on supported catalysts is not so homogeneous, and consists of miscellaneous morphological units, such as spirals, flakes, secondary fibrils, interconnecting the subparticles, large and small lamellae in depending of the catalyst system. The density of disordered regions in these reactor powders is less than that in the particles of M‐series. The tensile strength of the samples obtained by sintering of the M‐powders is higher than the strength of the other ones by a factor 2.5, which makes them good precursors for orientation drawing. © 2010 Wiley Periodicals, Inc. J Appl Polym Sci, 2010
Competitive plasticization in ternary plasticized starch biopolymer system
Authors: Chaudhary Deeptangshu S. 
Published: May 2010

AbstractTwo plasticizers namely, glycerol and xylitol, based on their similar molecular diameter (∼ 6.3 Å) but different molecular weights (glycerol‐92; xylitol‐152) were selected were selected for studying the plasticization of starch biopolymer containing 70% amylopectin structure via glass transition measurements carried over a wide range of water activity. A standard calorimetry was used to determine the onset temperature of polymeric viscous flow. For both glycerol and xylitol, typical antiplasticization was evident at low plasticizer concentrations, whereas at higher concentration, there was significant reduction in glass transition temperature. Water activity isotherms showed that equilibrium moisture content of the starch biopolymer (no plasticizer) steadily increases up to 11%, however, for plasticized biopolymer, the moisture content was nearly double than that of biopolymer. We used a modified Gordon‐Taylor model, using a new interaction parameter, to understand the competitive plasticization of glycerol and xylitol in presence of water, and determined 8 wt % water as a threshold amount of matrix water for strong three‐way interactions: starch‐plasticizer, plasticizer‐plasticizer/water and starch‐water. © 2010 Wiley Periodicals, Inc. J Appl Polym Sci, 2010
Rheology of bitumen modified by EVA—Organoclay nanocomposites
Authors: Markanday Subramanian Sureshkumar , Stastna Jiri , Polacco Giovanni , Filippi Sara , Kazatchkov Igor , Zanzotto Ludovit 
Published: May 2010

AbstractTernary systems, bitumen/ethylene‐vinyl acetate (EVA)/organoclay, were prepared by two mixing methods (physical mixing and melt blending) and then studied in small amplitude oscillations, start‐up of shear flow and repeated creep and recovery tests. The effect of mixing method and the role of two organoclays on the rheological properties of the studied systems were investigated. Improved thermomechanical properties of bitumen/EVA/organoclay nanocomposites, prepared by melt blending, were demonstrated by the low accumulated strain/compliance in the repeated creep and recovery tests. Structural differences between the studied systems were reflected in the behavior of the dynamic phase angle, specifically in the shape of the derivative of phase angle w.r.t. the reduced frequency. Similarly, the structural differences between the prepared nanocomposites were reflected by the behavior of the stress growth function η+ in the transient experiments. © 2010 Wiley Periodicals, Inc. J Appl Polym Sci, 2010
Preparation and characterization of polyalginate–glutaraldehyde membranes—Swelling analysis by microcalorimetry and adsorption kinetics of cationic dye
Authors: Vieira Eunice F. S. , da Costa Luiz P. , Cestari Antonio R. 
Published: May 2010

AbstractThin crosslinked polyalginate–glutaraldehyde membranes were prepared and characterized by Fourier‐transformed infrared spectroscopy, thermal analysis (TG/DTG), and X‐ray diffractometry. Microcalorimetric analyses have pointed out that water swellings of the membranes are slightly exothermic, and the swelling energies decrease with increasing temperature. The membranes were tested for the adsorption of methylene blue (MB) dye from aqueous solutions. The adsorption capacity of the membranes increased with increasing initial MB concentration and decreased with increasing temperature. It was observed that the MB adsorption kinetic data were best fitted by the Avrami model. Intraparticle diffusion of MB into the interior of the membranes was detected after 60 min of contact time. The MB adsorption on the membranes was also evaluated by three new 22 full factorial designs (36 experiments). It was found that binary interactions between initial dye concentration and temperature are statistically important for MB adsorption on the membranes. © 2010 Wiley Periodicals, Inc. J Appl Polym Sci, 2010