bluuebunny/crossref_metadata_2025_split huggingface dataset:
WuMKG: a Chinese painting and calligraphy multimodal knowledge graph
Authors: Wan Jing , Zhang Hao , Zou Jun , Zou Ao , Chen Yubin , Zeng Qingyang , Li Xinrong , Wang Qiya 
Published: May 2024

Abstract
Chinese Painting and Calligraphy (ChP&C) holds significant cultural value, representing integral aspects of both Chinese culture and global art. A considerable amount of ChP&C works are dispersed worldwide. With the emergence of digital humanities, a vast collection of cultural artifacts data is now available online. However, the online databases of these artifacts remain decentralized and diverse, posing significant challenges to their effective organization and utilization. Addressing this, our paper focuses on the Wu Men School of Painting and proposes a framework for constructing a multimodal knowledge graph for the ChP&C domain. We construct the domain ontology by analyzing the ChP&C knowledge schema. Then, we acquire knowledge from diverse data sources, including textual and visual information. To enhance data collection around collecting historical context and subject matter, we propose methods for seal extraction and subject extraction specific to ChP&C. We validate the effectiveness of these methods on the constructed dataset. Finally, we construct the Wu Men Multimodal Knowledge Graph (WuMKG) and implement applications such as cross-modal retrieval, knowledge-based question-answering and visualization.
A future scenario earthquake and ground motion hazards for Kathmandu, Nepal
Authors: Koketsu Kazuki , Miyake Hiroe , Okumura Koji , Suzuki Haruhiko 
Published: May 2024

AbstractSince Nepal is an earthquake-prone country due to the collision of the Indian and Eurasian plates, it is crucial for its capital of Kathmandu to evaluate ground motion hazards from a future large earthquake. For this purpose, we constructed a realistic scenario earthquake with realistic rupture parameters in a likely location. To obtain the location, a new distribution of the rupture zones of large historical earthquakes along the Main Himalayan Thrust (MHT) was obtained by integrating the distribution from a previous study and the results of trench surveys. Global Navigation Satellite System observations indicated that the plate boundary is strongly coupled from the southern boundary of the MHT to a depth of approximately 10 km and there is almost no lateral change in the coupling. This implies that all regions along the MHT have similar rates of strain increase. Therefore, it is most probable that the rupture zone of the oldest previous event will rupture as a scenario earthquake. In the new distribution, the 1255 earthquake is the oldest. However, large earthquakes occurred in 1934 and 2015 within its rupture zone. Thus, we adopted the area obtained by removing the 1934 and 2015 rupture zones from the western part of the 1255 rupture zone. The relationship between the rupture area size and seismic moment of the 2015 earthquake lies between the scaling formulas for crustal earthquakes and plate-boundary earthquakes, but is closer to the former. Therefore, using this and the scheme for characterized source models, we determined realistic rupture parameters. We then simulated broadband ground motions in Kathmandu using these rupture parameters, our 3-D velocity structure models, and a hybrid method combining the finite-difference method and the stochastic Green’s function method. We obtained the peak ground accelerations (PGAs) of simulated ground motions, and calculated the seismic intensities in the Modified Mercalli intensity scale from the PGAs as indexes of hazards for Kathmandu. Intensities IX coincide with the center of the Kathmandu Valley, and intensities VIII and VII are found in the area surrounded by the sedimentary boundary and the southernmost part of the valley.
Graphical abstract
Willingness to join community-based health insurance and its associated factors among households in Nekemte City, Ethiopia. A community-based cross-sectional study
Authors: Begna Olkeba , Gemede Habtamu Fekadu , Motuma Aboma , Shibiru Tesfaye , Tilahun Temesgen , Bobo Firew Tekle , Fite Meseret Belete 
Published: May 2024

Abstract
Introduction
Ethiopia has been implementing community-based health insurance programs since 2011 to improve health care financing system. However, the prevalence of household willingness to join the community-based health insurance (CBHI) program and its associated factors are less explored in urban area. Therefore, this study was aimed to assess the prevalence of willingness to join community-based health insurance program and its associated factors among households in Nekemte City, Ethiopia.

Methods
A community-based cross-sectional study was conducted on 422 randomly selected households in Nekemte City, Ethiopia. Bivariate and multivariable analyses were performed to see the association between the independent and outcome variables using binary logistic regression model. Association was described using an adjusted odd ratio (AOR) and a 95% confidence interval (CI). Finally, p-value < 0.05 was considered the cut-off point for declaring a significant.

Results
Among 422 study participants, 320 (75.83%) [95% CI = 71.5-79.8%)] of the households were willing to join community-based health insurance program. The willingness to join for community-based health insurance was 3.11 times more likely among households who were in the richest quintile (AOR = 3.11; 95% CI = 1.08–8.93), 3.4 times more likely among those who were merchants (AOR = 3.40;1.33, 8.69), 2.52 times more likely among those who had history of chronic illness in the household (AOR = 2.52; 95% CI = 1.43–4.45), 4.09 times more likely among those who had the awareness about the scheme (AOR = 4.09; 95% CI = 1.97–8.47) and 3.29 times more likely among those who had the experience of borrow for medical care (AOR = 3.29; 95% CI = 1.48–7.30).

Conclusion
Nearly three fourth of the households were willing to join community-based health insurance program, however, about one fourth of households were not willing, which is a significant public health problem. Being merchant, having awareness about the scheme, being in the richest wealth quintile, having experience of borrowing for medical care, and having history of chronic illness in the household were factors found to be significantly associated with willingness to join community based health insurance in the study area. Therefore, strengthening awareness creation at community level about the benefit package and principle of the program would increase their demand for the community-based health insurance scheme.
Socioeconomic determinants of early childhood development: evidence from Pakistan
Authors: Akram Shahla , Zahid Feroz , Pervaiz Zahid 
Published: May 2024

AbstractThis study investigates the socioeconomic determinants of early childhood development (ECD) in Pakistan by utilizing the data of sixth wave of the Multiple Indicator Cluster Survey (MICS) conducted in the four provinces of the country. The findings of the study reveal that mother’s education, father’s education, economic status of the household as measured by household’s wealth index quintile, region of residence (province), child’s gender, disability, nutrition and the practices used by the adult members of the household to discipline child are important determinants of ECD. The study highlights the crucial role of family background and importance of addressing the issue of malnutrition to foster child development.
Leaders’ experiences of embedding a simulation-based education programme in a teaching hospital: an interview study informed by normalisation process theory
Authors: Szabo Rebecca A. , Molloy Elizabeth , Allen Kara J. , Francis Jillian , Story David 
Published: May 2024

AbstractThere is limited research on the experiences of people in working to embed, integrate and sustain simulation programmes. This interview-based study explored leaders’ experiences of normalising a simulation-based education programme in a teaching hospital. Fourteen known simulation leaders across Australia and North America were interviewed. Semi-structured interviews were analysed using reflexive thematic analysis sensitised by normalisation process theory, an implementation science theory which defines ‘normal’ as something being embedded, integrated and sustained. We used a combined social and experiential constructivist approach. Four themes were generated from the data: (1) Leadership, (2) business startup mindset, (3) poor understanding of simulation undermines normalisation and (4) tension of competing objectives. These themes were interlinked and represented how leaders experienced the process of normalising simulation. There was a focus on the relationships that influence decision-making of simulation leaders and organisational buy-in, such that what started as a discrete programme becomes part of normal hospital operations. The discourse of ‘survival’ was strong, and this indicated that simulation being normal or embedded and sustained was still more a goal than a reality. The concept of being like a ‘business startup’ was regarded as significant as was the feature of leadership and how simulation leaders influenced organisational change. Participants spoke of trying to normalise simulation for patient safety, but there was also a strong sense that they needed to be agile and innovative and that this status is implied when simulation is not yet ‘normal’. Leadership, change management and entrepreneurship in addition to implementation science may all contribute towards understanding how to embed, integrate and sustain simulation in teaching hospitals without losing responsiveness. Further research on how all stakeholders view simulation as a normal part of a teaching hospital is warranted, including simulation participants, quality and safety teams and hospital executives. This study has highlighted that a shared understanding of the purpose and breadth of simulation is a prerequisite for embedding and sustaining simulation. An approach of marketing simulation beyond simulation-based education as a patient safety and systems improvement mindset, not just a technique nor technology, may assist towards simulation being sustainably embedded within teaching hospitals.
Effect of emphysema on AI software and human reader performance in lung nodule detection from low-dose chest CT
Authors: Sourlos Nikos , Pelgrim GertJan , Wisselink Hendrik Joost , Yang Xiaofei , de Jonge Gonda , Rook Mieneke , Prokop Mathias , Sidorenkov Grigory , van Tuinen Marcel , Vliegenthart Rozemarijn , van Ooijen Peter M. A. 
Published: May 2024

Abstract
Background
Emphysema influences the appearance of lung tissue in computed tomography (CT). We evaluated whether this affects lung nodule detection by artificial intelligence (AI) and human readers (HR).

Methods
Individuals were selected from the “Lifelines” cohort who had undergone low-dose chest CT. Nodules in individuals without emphysema were matched to similar-sized nodules in individuals with at least moderate emphysema. AI results for nodular findings of 30–100 mm3 and 101–300 mm3 were compared to those of HR; two expert radiologists blindly reviewed discrepancies. Sensitivity and false positives (FPs)/scan were compared for emphysema and non-emphysema groups.

Results
Thirty-nine participants with and 82 without emphysema were included (n = 121, aged 61 ± 8 years (mean ± standard deviation), 58/121 males (47.9%)). AI and HR detected 196 and 206 nodular findings, respectively, yielding 109 concordant nodules and 184 discrepancies, including 118 true nodules. For AI, sensitivity was 0.68 (95% confidence interval 0.57–0.77) in emphysema versus 0.71 (0.62–0.78) in non-emphysema, with FPs/scan 0.51 and 0.22, respectively (p = 0.028). For HR, sensitivity was 0.76 (0.65–0.84) and 0.80 (0.72–0.86), with FPs/scan of 0.15 and 0.27 (p = 0.230). Overall sensitivity was slightly higher for HR than for AI, but this difference disappeared after the exclusion of benign lymph nodes. FPs/scan were higher for AI in emphysema than in non-emphysema (p = 0.028), while FPs/scan for HR were higher than AI for 30–100 mm3 nodules in non-emphysema (p = 0.009).

Conclusions
AI resulted in more FPs/scan in emphysema compared to non-emphysema, a difference not observed for HR.

Relevance statement
In the creation of a benchmark dataset to validate AI software for lung nodule detection, the inclusion of emphysema cases is important due to the additional number of FPs.

Key points
• The sensitivity of nodule detection by AI was similar in emphysema and non-emphysema.
• AI had more FPs/scan in emphysema compared to non-emphysema.
• Sensitivity and FPs/scan by the human reader were comparable for emphysema and non-emphysema.
• Emphysema and non-emphysema representation in benchmark dataset is important for validating AI.

Graphical Abstract
An improved GNSS ambiguity best integer equivariant estimation method with Laplacian distribution for urban low-cost RTK positioning
Authors: Liu Ying , Liu Wanke , Zhang Xiaohong , Liang Yantao , Tao Xianlu , Ma Liye 
Published: May 2024

AbstractThe integer least squares (ILS) estimation is commonly used for carrier phase ambiguity resolution (AR). More recently, the best integer equivariant (BIE) estimation has also attracted an attention for complex application scenarios, which exhibits higher reliability by a weighted fusion of integer candidates. However, traditional BIE estimation with Gaussian distribution (GBIE) faces challenges in fully utilizing the advantages of BIE for urban low-cost positioning, mainly due to the presence of outliers and unmodeled errors. To this end, an improved BIE estimation method with Laplacian distribution (LBIE) is proposed, and several key issues are discussed, including the weight function of LBIE, determination of the candidates included based on the OIA test, and derivation of the variance of LBIE solutions for reliability evaluation. The results show that the proposed LBIE method has the positioning accuracy similar to the BIE using multivariate t-distribution (TBIE), and significantly outperforms the ILS-PAR and GBIE methods. In an urban expressway test with a Huawei Mate40 smartphone, the LBIE method has positioning errors of less than 0.5 m in three directions and obtains over 50% improvements compared to the ILS-PAR and GBIE methods. In an urban canyon test with a low-cost receiver STA8100 produced by STMicroelectronics, the positioning accuracy of LBIE in three directions is 0.112 m, 0.107 m, and 0.252 m, respectively, with improvements of 17.6%, 27.2%, and 26.1% compared to GBIE, and 23.3%, 28.2%, and 30.6% compared to ILS-PAR. Moreover, its computational time increases by 30–40% compared to ILS-PAR and is approximately half of that using TBIE.
Alleviative effect of betaine against copper oxide nanoparticles-induced hepatotoxicity in adult male albino rats: histopathological, biochemical, and molecular studies
Authors: Hashim Asmaa R. , Bashir Dina W. , Rashad Eman. , Galal Mona K. , Rashad Maha M. , Deraz Nasrallah M. , Drweesh Elsayed A. , El-Gharbawy S. M. 
Published: May 2024

AbstractBackgroundCopper oxide nanoparticles (CuO-NPs) have gained interest due to their availability, efficiency, and their cost-effectiveness. Betaine is an essential methyl donor and takes part in various physiological activities inside the body; it is found to have protective and curative effects against various liver diseases. The present study aimed to evaluate the hepatotoxic effect of CuO-NPs on adult male albino rats and the ability of betaine to alleviate such hepatotoxicity.MethodsForty adult male albino Wister rats were grouped into 4 groups (10 rats/group): group I a negative control, group II (CuO-NPs) injected with CuO-NPs intra peritoneal by insulin needle (0.5 mg/kg/day), group III (betaine + CuO-NPs) administered betaine orally by gavage needle (250 mg/kg/day 1 h before CuO-NPs) and CuO-NPs (0.5 mg/kg/day) finally, group IV (betaine) administered betaine orally by gavage needle (250 mg/kg/day) for consecutive 28 days. Blood and liver samples were gathered and processed for biochemical, molecular, histopathological, and immunohistochemical investigations.ResultsGroup II displayed a marked rise in alanine aminotransferase (ALT), aspartate aminotransferase (AST), and malondialdehyde (MDA) levels. Furthermore, there is an excessive upregulation of the inflammatory biomarkers interleukin1 beta (IL-1β) and tumor necrosis factor-alpha (TNF-α). On the other hand, substantial reduction in glutathione (GSH) levels and significant downregulation at glutathione peroxidase (GPx) mRNA gene expression. Regarding the histopathological deviations, there were severe congestion, dilatation and hyalinization of blood vessels, steatosis, hydropic degeneration, hepatocytic necrosis, increased binucleation, degenerated bile ducts, hyperplasia of ducts epithelial lining, and inflammatory cells infiltration. Immunohistochemically, there was a pronounced immunoreactivity toward IL-1β. Luckily, the pre-administration of betaine was able to mitigate these changes. MDA was dramatically reduced, resulting in the downregulation of IL-1β and TNF-α. Additionally, there was a considerable rise in GSH levels and an upregulation of GPx. Histopathological deviations were substantially improved as diminished dilatation, hyalinization and congestion of blood vessels, hepatocytes, and bile ducts are normal to some extent. In addition, IL-1β immunohistochemical analysis revealed marked decreased intensity.ConclusionBetaine can effectively reduce the hepatotoxicity caused by CuO-NPs via its antioxidant properties and its ability to stimulate the cell redox system.
Someone is to blame: the impact of suicide on the mind of the bereaved (including clinicians)
Authors: Gibbons Rachel 
Published: May 2024

SummaryThis paper presents an emerging understanding of the psychodynamics of suicide loss, derived from over 1500 accounts of suicide bereavement shared by families, friends and clinicians. It identifies clear patterns in the responses of the bereaved, particularly the formation of delusional narratives that often place them at the centre of blame for the death. These narratives have a profound impact on well-being, increase the risk of mental illness and elevate the likelihood of death by suicide. They not only cause harm to the bereaved but also permeate and distort our systemic and societal responses. Understanding why suicide unleashes such painful and dangerous forces helps mitigate the widespread harm and distress that often follows such a death. This knowledge also enables us to effectively and compassionately support those bereaved.
Genetic Associations With C-peptide Levels Before Type 1 Diabetes Diagnosis in At-risk Relatives
Authors: Triolo Taylor M , Parikh Hemang M , Tosur Mustafa , Ferrat Lauric A , You Lu , Gottlieb Peter A , Oram Richard A , Onengut-Gumuscu Suna , Krischer Jeffrey P , Rich Stephen S , Steck Andrea K , Redondo Maria J 
Published: May 2024

Abstract

Objective
We sought to determine whether the type 1 diabetes genetic risk score-2 (T1D-GRS2) and single nucleotide polymorphisms are associated with C-peptide preservation before type 1 diabetes diagnosis.

Methods
We conducted a retrospective analysis of 713 autoantibody-positive participants who developed type 1 diabetes in the TrialNet Pathway to Prevention Study who had T1DExomeChip data. We evaluated the relationships of 16 known single nucleotide polymorphisms and T1D-GRS2 with area under the curve (AUC) C-peptide levels during oral glucose tolerance tests conducted in the 9 months before diagnosis.

Results
Higher T1D-GRS2 was associated with lower C-peptide AUC in the 9 months before diagnosis in univariate (β = −.06, P &lt; .0001) and multivariate (β = −.03, P = .005) analyses. Participants with the JAZF1 rs864745 T allele had lower C-peptide AUC in both univariate (β = −.11, P = .002) and multivariate (β = −.06, P = .018) analyses.

Conclusion
The type 2 diabetes-associated JAZF1 rs864745 T allele and higher T1D-GRS2 are associated with lower C-peptide AUC before diagnosis of type 1 diabetes, with implications for the design of prevention trials.
Acute and Long-Term Management of Blunt Cerebrovascular Injury at a Quaternary Referral Level 1 Trauma Center: The Memphis Experience and Comparison of a New Scoring System
Authors: Motiwala Mustafa , Nguyen Vincent N. , Orr Taylor , Parikh Kara A. , Miller Lindsey Erin , Barats Michael , Roach Jordan T. , Himel Sean , Mulpur Bhageeradh , Khattar Nicolas K. , Kerwin Andrew J. , Croce Martin , Arthur Adam , Inoa-Acosta Violiza , Nickele Christopher , Hoit Daniel , Elijovich Lucas , Goyal Nitin , Khan Nickalus R. 
Published: May 2024

BACKGROUND AND OBJECTIVES:
The management of blunt cerebrovascular injuries (BCVIs) remains an important topic within trauma and neurosurgery today. There remains a lack of consensus within the literature and significant variation across institutions. The purpose of this study was to evaluate management of BCVI at a large, tertiary referral trauma center.

METHODS:
Institutional Review Board approval was obtained to conduct a retrospective review of patients with BCVI at our Level 1 Trauma Center. Computed tomography angiography was used to identify BCVI for each patient. Patient information was collected, and statistical analysis was performed. With the included risk factors for ischemic complications, a novel scoring system based on ischemic risk, the “Memphis Score,” was developed and evaluated to grade BCVI.

RESULTS:
Two hundred seventeen patients with BCVI from July 2020 to August 2022 were identified. The most common mechanism of injury was motor vehicle collision (141, 65.0%). Vertebral arteries were the most common vessel injured (136, 51.1%) with most injuries occurring at a high cervical location (101, 38.0%). Denver Grade 1 injuries (89, 33.5%) and a Memphis Score of 1 were most frequent (172, 64.6%), and initial anticoagulation with heparin drip was initiated 56.7% of the time (123). Endovascular treatment was required in 24 patients (11.1%) and was usually performed in the first 48 hours (15, 62.5%). While Denver Grade (P = .019) and Memphis Score (P < .00001) were significantly higher in those patients undergoing endovascular treatment, only the Memphis Score demonstrated a significant difference between those patients who had stroke or worsening on follow-up imaging and those who did not (P = .0009).

CONCLUSION:
Although BCVI management has improved since early investigative efforts, institutions must evaluate and share their data to help clarify outcomes. The novel “Memphis Score” presents a standardized framework to communicate ischemic risk and guide management of BCVI.