bluuebunny/crossref_metadata_2025_split huggingface dataset:
Incidence and risk factors for radiographic knee osteoarthritis and knee pain in Japanese men and women: A longitudinal population‐based cohort study
Authors: Muraki Shigeyuki , Akune Toru , Oka Hiroyuki , Ishimoto Yuyu , Nagata Keiji , Yoshida Munehito , Tokimura Fumiaki , Nakamura Kozo , Kawaguchi Hiroshi , Yoshimura Noriko 
Published: December 2011

AbstractObjectiveTo examine the incidence and progression of radiographic knee osteoarthritis (OA) and the incidence of knee pain, and their risk factors in Japan, using the large‐scale population of the nationwide cohort study ROAD (Research on Osteoarthritis/osteoporosis Against Disability).MethodsSubjects from the ROAD study who had been recruited in 2005–2007 were followed up with knee radiography 3 years later. A total of 2,262 paired radiographs (74.4% of the original sample) were scored using the Kellgren/Lawrence (K/L) grading system, and the incidence and progression rate of knee OA was examined. The incidence rate of knee pain was also examined. In addition, risk factors were tested for their association with incident and progressive radiographic knee OA and incident knee pain.ResultsGiven the ∼3.3‐year followup, the rate of incident K/L grade ≥2 radiographic knee OA was 6.9% and 11.9% in men and women, respectively, while that of K/L grade ≥3 knee OA was 8.4% and 13.9% in men and women, respectively. The rate of progressive knee OA was 17.8% and 22.3% in men and women, respectively. The incident rate of knee pain was 21.2% and 27.3% in men and women, respectively. Female sex was a risk factor for incident K/L grade ≥2 knee OA, but was not associated with incident K/L grade ≥3 knee OA or progressive knee OA. Knee pain was a risk factor for incident and progressive knee OA. Previous knee injury was a risk factor for knee pain but not for radiographic knee OA.ConclusionThe present longitudinal study revealed a high incidence of radiographic knee OA in Japan.
Now for Me, Later for Us? Effects of Group Context on Temporal Discounting
Authors: Charlton Shawn R. , Yi Richard , Porter Caitlin , Carter Anne E. , Bickel Warren , Rachlin Howard 
Published: December 2011

ABSTRACTDelayed rewards are less valuable than immediate rewards. This well‐established finding has focused almost entirely on individual outcomes. However, are delayed rewards similarly discounted if they are shared by a group? The current article reports on three experiments exploring the effect of group context on delay discounting. Results indicate that discount rates of individual and group rewards were highly correlated, but that respondents were more willing to wait (decreased discounting) for shared outcomes than for individual outcomes. An explanatory model is proposed suggesting that decreased discount rates in group contexts may be due to the way the effects of both delay and social discounting are combined. That is, in a group context, a person values both a future reward (discounted by delay) and a present reward to another person (discounted by the social distance between them). The results are explained by a combined discount function containing a delay factor and a factor representing the social distance between the decision maker and group members. Practical implications of the fact that shared consequences can increase individual self‐control are also discussed. Copyright © 2011 John Wiley & Sons, Ltd.
Wildbrücke Völkermarkt – vorgespanntes Bogentragwerk aus UHFB‐Segmentfertigteilen
Authors: Reichel Michael , Sparowitz Lutz , Freytag Bernhard 
Published: December 2011

AbstractDieser Beitrag stellt die Fortsetzung des ersten Teiles des Aufsatzes “Entwurf und Bemessung der Wildbrücke Völkermarkt” dar, einer Talbrücke mit einem extern vorgespannten Bogen, bestehend aus dünnwandigen Hohlkastensegmentfertigteilen aus ultrahochfestem Beton (UHFB). Es werden die Besonderheiten bei der Fertigung im Werk, die Montage und Errichtung auf der Baustelle sowie die begleitenden Versuche und die Qualitätsüberwachung als auch die gewonnenen Erfahrungen im Rahmen der Umsetzung beschrieben. Mit dem Bau dieses Pilotprojektes konnte das Potenzial von UHFB bei einer Anwendung für Brückenbauwerke eindrucksvoll gezeigt und durch die äußerst kurze Bauzeit von weniger als zehn Arbeitstagen zur Errichtung des Bogens bestätigt werden. Letztlich ist der Bau der Wildbrücke Völkermarkt ein weiterer Beweis dafür, dass das Entwicklungspotenzial im Betonbau noch lange nicht erschöpft ist und eine werkstoffgerechte Anwendung neuer Materialien zu immer wieder neuen und wirtschaftlichen Lösungen führen kann.Bridge WILD Völkermarkt – prestressed arched structure made of precast UHPC‐segments. Part 2 – Erection, accompanying research, quality controlThe WILD‐bridge spans a romantic valley at the periphery of Völkermarkt in Carinthia. The main structure is an arch consisting of thin‐walled pre‐cast elements made of ultra high performance concrete (UHFB). The arch is pre‐stressed by means of bondless tendons which are arranged in the hollow space of the box‐shaped pre‐cast elements. This paper continuous the first part, which deals with design and detailing of WILD‐bridge. The focus here is on various issues of the realisation. These are the production of the pre‐cast members, assembling and erection as well as particular approval experiments and the procedure of quality examination. The mounting of the arch took only ten working days, which shows the high potential of UHFB in the building of bridges as far as economic efficiency is concerned. The project WILD‐bridge impressively shows that the possibilities for innovation and development in the field of concrete construction are far from being exhausted. Further bridge projects with UHFB might benefit from the manifold experience gained from this successful pilot project.
Rational bioprocess design for human pluripotent stem cell expansion and endoderm differentiation based on cellular dynamics
Authors: Ungrin Mark D. , Clarke Geoff , Yin Ting , Niebrugge Sylvia , Nostro M. Cristina , Sarangi Farida , Wood Geoffrey , Keller Gordon , Zandstra Peter W. 
Published: December 2011

AbstractWe present a predictive bioprocess design strategy employing cell‐ and molecular‐level analysis of rate‐limiting steps in human pluripotent stem cell (hPSC) expansion and differentiation, and apply it to produce definitive endoderm (DE) progenitors using a scalable directed‐differentiation technology. We define a bioprocess optimization parameter (L; targeted cell Loss) and, with quantitative cell division tracking and fate monitoring, identify and overcome key suspension bioprocess bottlenecks. Adapting process operating conditions to pivotal parameters (single cell survival and growth rate) in a cell‐line‐specific manner enabled adherent‐equivalent expansion of hPSCs in feeder‐ and matrix‐free defined‐medium suspension culture. Predominantly instructive differentiation mechanisms were found to underlie a subsequent 18‐fold expansion, during directed differentiation, to high‐purity DE competent for further commitment along pancreatic and hepatic lineages. This study demonstrates that iPSC expansion and differentiation conditions can be prospectively specified to guide the enhanced production of target cells in a scale‐free directed differentiation system. Biotechnol. Bioeng. 2012; 109:853–866. © 2011 Wiley Periodicals, Inc.
From intervention informatics to prevention informatics
Authors: Fuller Sherrilynne 
Published: December 2011

AbstractThe contributions of the information science community to health care are significant, especially through systems supporting clinical care for individual patients, an intervention informatics approach. Though valuable, this strategy is reactive, fails to account for numerous environmental factors affecting personal health and falls short of enhancing human health on a broader scale. An unmet challenge with abundant opportunity lies in prevention informatics, a proactive approach drawing on information science and technologies to deliver greater health gains at a population level. Prevention informatics is marked by a high degree social interactivity in real time, with technologies to bring together disparate data and represent it in an integrated and meaningful way as the basis for action. The approach relies on standards for classifying information, systematic knowledge management and improved methods to collect, mine and visualize data. Tools and software are already in use in locations around the world, relying on smartphone technology and geographic information systems to share community health information and location data. Further advances in prevention informatics will require adoption of common terminologies, visualization tools and GIS mapping, and optimized data exchange to support rapid prevention response.
Glycine Fluoromethylketones as SENP‐Specific Activity Based Probes
Authors: Dobrotă Cristian , Fasci Domenico , Hădade Niculina D. , Roiban Gheorghe‐Doru , Pop Cristina , Meier Veronika M. , Dumitru Ioana , Matache Mihaela , Salvesen Guy S. , Funeriu Daniel P. 
Published: December 2011

AbstractWe report here the synthesis and biochemical properties of a new peptidyl activity‐based probe 1 for SUMO proteases, SENPs. The activity‐based probe has at its C terminus a glycine‐derived fluoromethylketone moiety as a reactive group designed to target the active‐site cysteine of SENPs. Based on a study of the interactions between SENPs and SUMOs, we introduced further design elements that allow the activity‐based probe to selectively target SENPs at low micromolar to high nanomolar concentrations. Moreover, 1 out‐competes SUMO1 from the reversible SUMO1–SENP1 complex, thus suggesting that 1 and SUMO1 share a common binding site on SENP1.
Photocrosslinking between Peptide–Peptide or Peptide–Oligonucleotide by RuII–TAP Complexes
Authors: Ghesquière Jonathan , Gauthier Nicolas , De Winter Julien , Gerbaux Pascal , Moucheron Cécile , Defrancq Eric , Kirsch‐De Mesmaeker Andrée 
Published: December 2011

AbstractRuII–TAP complexes have been shown to be very attractive compounds in the frame of developments of new anticancer drugs targeting the genetic material. This increasing interest originates from observations of covalent bond formations, triggered by photo‐induced electron transfer (PET) between RuII–TAP complexes and guanine bases of DNA. This photoreaction has recently been extended to the tryptophan (Trp) amino acid for future applications involving peptides. Thus, a double photo‐addition of Trp residues of peptides on RuII complexes is demonstrated by mass spectrometry with some structural issues. Such bi‐adduct formations offer the possibility of photocrosslinking two Trp‐containing biomolecules, which is investigated in this study. Thus, photocrosslinking between two complementary oligonucleotides (ODNs) derivatized by Trp‐containing tripeptides is demonstrated by polyacrylamide gel electrophoresis (PAGE) in the presence of RuII–TAP complexes. Both PAGE and MS indicate that such photocrosslinkings arise from two reaction pathways: either via the double addition of Trp residues on the Ru complex or from dimerization of Trp radicals. The competition between these two pathways depends on the experimental conditions. Heterobridgings between guanine bases and tryptophan residues mediated by RuII–TAP complexes is also examined, opening the way to ODN–peptide photocrosslinkings.
Is the Conventional Interpretation of the Anisotropic Effects of CC Double Bonds and Aromatic Rings in NMR Spectra in Terms of the π‐Electron Shielding/Deshielding Contributions Correct?
Authors: Baranac‐Stojanović Marija , Koch Andreas , Kleinpeter Erich 
Published: December 2011

AbstractBased on the nucleus‐independent chemical shift (NICS) concept, isotropic magnetic shielding values have been computed along the three Cartesian axes for ethene, cyclobutadiene, benzene, naphthalene, and benzocyclobutadiene, starting from the molecular/ring center up to 10 Å away. These through‐space NMR spectroscopic shielding (TSNMRS) values, which reflect the anisotropic effects, have been broken down into contributions from localized‐ and canonical molecular orbitals (LMOs and CMOs); these contributions revealed that the proton NMR spectroscopic chemical shifts of nuclei that are spatially close to the CC double bond or the aromatic ring should not be explained in terms of the conventionally accepted π‐electron shielding/deshielding effects. In fact, these effects followed the predictions only for the antiaromatic cyclobutadiene ring.
General Bottom‐Up Construction of Spherical Particles by Pulsed Laser Irradiation of Colloidal Nanoparticles: A Case Study on CuO
Authors: Wang Hongqiang , Kawaguchi Kenji , Pyatenko Alexander , Li Xiangyou , Swiatkowska‐Warkocka Zaneta , Katou Yukiko , Koshizaki Naoto 
Published: December 2011

AbstractThe development of a general method to fabricate spherical semiconductor and metal particles advances their promising electrical, optical, magnetic, plasmonic, thermoelectric, and optoelectric applications. Herein, by using CuO as an example, we systematically demonstrate a general bottom‐up laser processing technique for the synthesis of submicrometer semiconductor and metal colloidal spheres, in which the unique selective pulsed heating assures the formation of spherical particles. Importantly, we can easily control the size and phase of resultant colloidal spheres by simply tuning the input laser fluence. The heating–melting–fusion mechanism is proposed to be responsible for the size evolution of the spherical particles. We have systematically investigated the influence of experimental parameters, including laser fluence, laser wavelength, laser irradiation time, dispersing liquid, and starting material concentration on the formation of colloidal spheres. We believe that this facile laser irradiation approach represents a major step not only for the fabrication of colloidal spheres but also in the practical application of laser processing for micro‐ and nanomaterial synthesis.
Rare‐Earth Metal Allyl and Hydrido Complexes Supported by an (NNNN)‐Type Macrocyclic Ligand: Synthesis, Structure, and Reactivity toward Biomass‐Derived Furanics
Authors: Abinet Elise , Martin Daniel , Standfuss Sabine , Kulinna Heiko , Spaniol Thomas P. , Okuda Jun 
Published: December 2011

AbstractThe preparation and characterization of a series of neutral rare‐earth metal complexes [Ln(Me3TACD)(η3‐C3H5)2] (Ln=Y, La, Ce, Pr, Nd, Sm) supported by the 1,4,7‐trimethyl‐1,4,7,10‐tetraazacyclododecane anion (Me3TACD−) are reported. Upon treatment of the neutral allyl complexes [Ln(Me3TACD)(η3‐C3H5)2] with Brønsted acids, monocationic allyl complexes [Ln(Me3TACD)(η3‐C3H5)(thf)2][B(C6X5)4] (Ln=La, Ce, Nd, X=H, F) were isolated and characterized. Hydrogenolysis gave the hydride complexes [Ln(Me3TACD)H2]n (Ln=Y, n=3; La, n=4; Sm). X‐ray crystallography showed the lanthanum hydride to be tetranuclear. Reactivity studies of [Ln(Me3TACD)R2]n (R=η3‐C3H5, n=0; R=H, n=3,4) towards furan derivatives includes hydrosilylation and deoxygenation under ring‐opening conditions.
Oxygen Atom Transfer from a trans‐Dioxoruthenium(VI) Complex to Nitric Oxide
Authors: Man Wai‐Lun , W. Y. Lam William , Ng Siu‐Mui , Y. K. Tsang Wenny , Lau Tai‐Chu 
Published: December 2011

AbstractIn aqueous acidic solutions trans‐[RuVI(L)(O)2]2+ (L=1,12‐dimethyl‐3,4:9,10‐dibenzo‐1,12‐diaza‐5,8‐dioxacyclopentadecane) is rapidly reduced by excess NO to give trans‐[Ru(L)(NO)(OH)]2+. When ≤1 mol equiv NO is used, the intermediate RuIV species, trans‐[RuIV(L)(O)(OH2)]2+, can be detected. The reaction of [RuVI(L)(O)2]2+ with NO is first order with respect to [RuVI] and [NO], k2=(4.13±0.21)×101 M−1 s−1 at 298.0 K. ΔH≠ and ΔS≠ are (12.0±0.3) kcal mol−1 and −(11±1) cal mol−1 K−1, respectively. In CH3CN, ΔH≠ and ΔS≠ have the same values as in H2O; this suggests that the mechanism is the same in both solvents. In CH3CN, the reaction of [RuVI(L)(O)2]2+ with NO produces a blue‐green species with λmax at approximately 650 nm, which is characteristic of N2O3. N2O3 is formed by coupling of NO2 with excess NO; it is relatively stable in CH3CN, but undergoes rapid hydrolysis in H2O. A mechanism that involves oxygen atom transfer from [RuVI(L)(O)2]2+ to NO to produce NO2 is proposed. The kinetics of the reaction of [RuIV(L)(O)(OH2)]2+ with NO has also been investigated. In this case, the data are consistent with initial one‐electron O− transfer from RuIV to NO to produce the nitrito species [RuIII(L)(ONO)(OH2)]2+ (k2>106 M−1 s−1), followed by a reaction with another molecule of NO to give [Ru(L)(NO)(OH)]2+ and NO2− (k2=54.7 M−1 s−1).
Removal efficiency of heavy oil by free and immobilised microorganisms on laboratory‐scale
Authors: Bao Mutai , Chen Qingguo , Gong Yuanjiao , Li Yiming , Wang Haifeng , Jiang Guancheng 
Published: December 2011

AbstractThis study explored free and immobilised microorganisms to degrade heavy oil. Two oil‐degrading bacterial strains (W‐1 and W‐2) were isolated from heavy oil wastewater samples collected from Shengli Oil Field in China. W‐1 and W‐2, identified as Rhosococcus sp. and Bacillus cereus sp., respectively, were tested for their growth behaviour and optimal growth conditions in the laboratory. The obtained results showed that the optimal growth conditions for W‐1 and W‐2 were identified as pH of 8, temperature of 40°C, and salinity of 2% and 4%, respectively. The environmental conditions affecting oil‐degrading efficiency by W‐1 and W‐2 were optimised in the media containing 0.3% heavy oil. The results showed that the optimal degradation and optimal growth conditions were similar, and the oil degradation rates of W‐1 and W‐2 were about 34.6% and 45.3%, respectively after 5 days.W‐1 and W‐2 capable of degrading oil was immobilised in calcium alginate gel beads containing active carbon and used for degradation of heavy oil. The heavy oil biodegradability of immobilised bacteria improved dramatically, compared with that of the free ones. The heavy oil biodegradation rates of immobilised W‐2 were found to be maximal at the same optimal growth conditions of pH, temperature, and salinity as the free ones. The best biodegradation rate of immobilised W‐2 reached above 78%, which is 33% than that of the free W‐2. © 2011 Canadian Society for Chemical Engineering
Effects of basic calponin on the flexural mechanics and stability of F‐actin
Authors: Jensen Mikkel Herholdt , Watt James , Hodgkinson Julie L. , Gallant Cynthia , Appel Sarah , El‐Mezgueldi Mohammed , Angelini Thomas E. , Morgan Kathleen G. , Lehman William , Moore Jeffrey R. 
Published: December 2011

AbstractThe cellular actin cytoskeleton plays a central role in the ability of cells to properly sense, propagate, and respond to external stresses and other mechanical stimuli. Calponin, an actin‐binding protein found both in muscle and non‐muscle cells, has been implicated in actin cytoskeletal organization and regulation. In this work, we studied the mechanical and structural interaction of actin with basic calponin, a differentiation marker in smooth muscle cells, on a single filament level. We imaged fluorescently labeled thermally fluctuating actin filaments and found that at moderate calponin binding densities, actin filaments were more flexible, evident as a reduction in persistence length from 8.0 to 5.8 μm. When calponin‐decorated actin filaments were subjected to shear, we observed a marked reduction of filament lengths after decoration with calponin, which we argue was due to shear‐induced filament rupture rather than depolymerization. This increased shear susceptibility was exacerbated with calponin concentration. Cryo‐electron microscopy results confirmed previously published negative stain electron microscopy results and suggested alterations in actin involving actin subdomain 2. A weakening of F‐actin intermolecular association is discussed as the underlying cause of the observed mechanical perturbations. © 2011 Wiley Periodicals, Inc
Retrospective analysis of antitumor effects of zoledronic acid in breast cancer patients with bone‐only metastases
Authors: Niikura Naoki , Liu Jun , Hayashi Naoki , Palla Shana L. , Tokuda Yutaka , Hortobagyi Gabriel N. , Ueno Naoto T. , Theriault Richard L. 
Published: December 2011

AbstractBACKGROUND:Bisphosphonates have been used successfully in the treatment of hypercalcemia and to reduce skeletal complications of bone metastasis, but have not been shown to prevent bone metastasis or to prolong survival time in metastatic breast cancer patients. The aim of this study was to determine whether the progression‐free survival (PFS) and overall survival (OS) of patients with bone‐only breast cancer metastasis differed based on whether patients received zoledronic acid, pamidronate, or no bisphosphonate upon diagnosis of their metastases.PATIENTS AND METHODS:We retrospectively identified 314 patients diagnosed with bone‐only metastasis at the time of initial staging or who developed bone metastasis as the first recurrence site during follow‐up from January 1, 1997 to December 31, 2008, at The MD Anderson Cancer Center. Univariate and multivariate Cox hazards models were used to assess the effects of each treatment on PFS and OS.RESULTS:Patients who had more than 1 bone metastasis and Eastern Cooperative Oncology Group (ECOG) performance status of 2 and 3 were more likely to receive zoledronic acid in this analysis. Compared with no bisphosphonate use, the use of zoledronic acid was not significantly associated with longer PFS (hazard ratio [HR] = 0.72, P = .058 in univariate analysis, and HR = 0.80, P = .235 in multivariate analysis) nor with longer OS (HR = 1.04, P = .863 in univariate analysis and HR = 1.34, P = .192 in multivariate analysis).CONCLUSION:Our study demonstrates that for patients with bone‐only metastases, zoledronic acid did not prolong PFS or OS. In patients with bone‐only metastasis, we could not demonstrate antitumor effects of zoledronic acid. Cancer 2012. © 2011 American Cancer Society.
The prognostic difference of monoallelic versus biallelic deletion of 13q in chronic lymphocytic leukemia
Authors: Garg Ravin , Wierda William , Ferrajoli Alessandra , Abruzzo Lynne , Pierce Sherry , Lerner Susan , Keating Michael , O'Brien Susan 
Published: December 2011

AbstractBACKGROUND:Fluorescence in situ hybridization can detect genomic abnormalities in up to 80% of cases and provides prognostic information on patients with chronic lymphocytic leukemia (CLL). Although 13q deletion as the sole abnormality has been found to confer a favorable prognosis, there are little data as to whether there is a difference in prognostic value between monoallelic versus biallelic deletion of 13q.METHODS:The authors reviewed the electronic database for patients with CLL who carried the 13q deletion as the sole abnormality and presented to The University of Texas MD Anderson Cancer Center (MDACC). Untreated patients were separated into 2 groups: those having monoallelic versus those with biallelic deletion of 13q. Using Mann‐Whitney, chi‐square, and Kaplan‐Meier analysis, the baseline quantitative and qualitative variables for each group, along with the time from presentation to MDACC to treatment, were compared.RESULTS:A total of 176 patients were identified; 143 patients had a monoallelic deletion of 13q, whereas 33 patients had a biallelic deletion. The only significantly different values between the groups were albumin (4.5 g/dL vs 4.4 g/dL; P = .01) and zeta‐chain‐associated protein kinase 70 (ZAP70) expression (1.7% vs 4.8%; P = .010). The median time from fluorescence in situ hybridization analysis to treatment in both the monoallelic and biallelic groups had not been reached (P = not significant).CONCLUSIONS:Except for inconsequential differences in albumin and ZAP70 expression, there was no difference in the baseline characteristics between patients with CLL who had monoallelic or biallelic deletion of 13q. In addition, there was no significant difference in endpoints, including time to treatment. Cancer 2012;3531–3537. © 2011 American Cancer Society.