bluuebunny/crossref_metadata_2025_split huggingface dataset:
ASSESSMENT OF COMMUNICATIVE COMPETENCIES FORMATION AMONG PEDAGOGICAL STUDENTS
Authors: Сапожникова О.Б. 
Published: June 2024

В статье рассматривается роль коммуникативных компетенций в структуре педагогической профессии. Представлен обобщенный взгляд на компоненты универсальных и коммуникативных компетенций, поднимается вопрос оценки компетенций, особенно применительно к педагогическим направлениям подготовки. Приведен опыт оценки коммуникативных компетенций у обучающихся по педагогическим направлениям подготовки. Проведенная многоуровневая диагностика сформированности коммуникативной компетенции продемонстрировала необходимость педагогического наблюдения за будущим педагогом в процессе обучения в вузе, особенно в процессе его взаимодействия с детьми, поскольку ни один тест не дает полной и объективной картины уместности проявления той или иной компетенции.
The article considers the role of communicative competences in the structure of the pedagogical profession. The author presents a generalized view of the components of universal and communicative competences, addresses the issue of competences assessment, especially applicable to pedagogical areas of training. The experience in the assessment of communicative competences of pedagogical students is described. The conducted multi-level diagnostics of the development of communicative competences among the students demonstrated the need for pedagogical supervision of the future students in the process of their studying at the university, especially during their interaction with schoolchildren, because no test gives a complete and objective picture of the relevance of a particular competence’s manifestation.
Assessment of cardiac function in farmers occupationally exposed to pesticides in gboko local government area, benue state
Authors: Obiorah Oluchukwu Maryrose , Meludu Chukwuemeka Samuel , Onah Ejike Christian , Okeke Chinenye Stellamaris , Ogbodo Chukwuemeka Emmanuel , Akaeme Chinonso Juliet , Agwaraonye Kelechi Christian 
Published: June 2024

Any compound or combination of substances meant to prevent, eradicate, repel, or mitigate any pest is known as a pesticide. Despite the benefits of using pesticides for pests, weeds, and disease control, there have been concerns about adverse effects of these compounds on the human health. This cross-sectional study was designed to assess the cardiac function of farmers occupationally exposed to pesticides, in Gboko Local Government Area, Benue State, Nigeria.One hundred ten (110) participants comprising 70 farmers and 40 controls were recruited for the study using a multi-stage random sampling technique. They were aged between 20-60 years and were age-matched. Five (5) ml of fasting blood samples were collected from each participant for the determination of Apolipoprotein A1 (ApoA1), Apolipoprotein B-100 (ApoB100) and Troponin I level using standard laboratory methods. Also, the body mass index (BMI), systolic blood pressure (SBP) and diastolic blood pressure (DBP) of the participants were also determined. The results showed significantly lower mean BMI (23.02±3.94 Vs 24.94±3.12; p= 0.031) and serum ApoA1 (150.73±13.52 Vs 167.27±15.65; p=0.024) while the mean SBP (140.49±19.34 Vs 119.75±10.30; p=0.000), DBP (82.86±12.16 Vs 77.53±7.76; p=0.014) and mean serum Troponin-I (3.11±5.46 Vs 1.38±0.15; p=0.049) levels were significantly higher in the farmers compared to control respectively. However, there was no significant difference in the mean serum ApoB-100 level in the farmers when compared to the control group (p=0.104). : This study showed that the farmers had lower body mass index and higher serum levels of apoA-I, apoB-100, and Troponin I, as well as systolic and diastolic blood pressure, as compared to the control group. Nonetheless, in both the test and control groups, these results fell within the typical reference ranges. Further longitudinal research is required to gain a deeper understanding of the effects of pesticide exposure on cardiac function in farmers.
Escore Fisiológico Agudo Simpli?cado como preditor de diminuição de Força Muscular Expiratória em indivíduos após alta da Unidade de Terapia Intensiva
Authors: Corlatti Katiúcia Pezzi , Monteiro Mariane Borba , Forgiarini Junior Luiz Alberto 
Published: June 2024

Objetivo: Correlacionar SAPS III, força muscular ventilatória e preensão palmar em pacientes após a alta da UTI. Material e Métodos: estudo transversal, amostra foi composta por 21 indivíduos maiores de 18 anos que tenham sido admitidos na UTI nesse período. Analisado Escore Fisiológico Agudo Simplificado III (SAPS III), avaliação da força muscular ventilatória e força de preensão palmar até 48 horas após a alta do paciente para a unidade de internação clínica. Resultados: Foram avaliados 21 adultos, sendo 11 internados devido à cirurgia cardíaca e 10 por outros tipos de cirurgia (não cardíaca). A média de idade dos pacientes foi de 53,90±15,96 anos, com um predomínio de 52,4% do sexo feminino. O grupo referente a outras cirurgias permaneceu mais tempo em ventilação mecânica e apresentou risco de mortalidade (p=0,040) e mortalidade para América do Sul (p=0,035) significativamente maior, quando comparado aos cardíacos. Em relação a força muscular periférica e ventilatória foi observado que a preensão palmar foi 118,2% do predito para este indivíduos, enquanto que a PImáx foi 60,9% do previsto enquanto que a PEmáx foi 51,63%, evidenciando diminuição de ambas. Ao correlacionarmos SAPS III com força ventilatória e periférica foi encontrado uma relação inversa significativa demonstrando que quanto maior a gravidade menor a PEmáx. Conclusão: Neste estudo foi possível verificar que a escala SAPS III pode ser um preditor de diminuição de força muscular expiratória em pacientes cirúrgicos após alta da UTI.
Segurança de alimentos no contexto escolar: concepções dos manipuladores de alimentos
Authors: Macedo Thamiris Rodrigues , Bento Isabel Cristina , Dos Santos Luana Caroline , Gazzinelli Bethony Maria Flávia , Pereira Simone Cardoso Lisboa 
Published: June 2024

Objetivo: Analisar as representações sociais de manipuladores de alimentos acerca das boas práticas de higiene no preparo dos alimentos no âmbito escolar. Método: estudo exploratório quantiqualitativo conduzido em escolas municipais de Belo Horizonte-MG. Utilizou-se o Teste projetivo de evocação livre de palavras aplicado com a expressão indutora “Higiene no preparo da merenda”. Apurou-se as justificativas do termo elencado como o mais importante e realizou-se análise do discurso do sujeito coletivo (DSC). Adotou-se como referenciais a Teoria das Representações Sociais, a abordagem estrutural e os pressupostos sociológicos.Resultados: Participaram 274 manipuladores de alimentos dos nove distritos sanitários do município. Constatou-se na análise estrutural, a “Higienização” e “Importante” foram os componentes representacionais centrais; observou-se 15 elementos intermediários, “Higiene pessoal” em destaque; e oito periféricos, “Armazenar”, como mais frequente. Identificou-se dois grupos de representações sociais: 1) procedimentos operacionais de boas práticas de manipulação dos alimentos; 2) importância das boas práticas de manipulação dos alimentos para a promoção da saúde.Conclusão: Os elementos do núcleo central e periferia apresentaram aspectos positivos em relação à temática estudada. Os elementos identificados na periferia devem ser alvo inicial das ações educativas, possibilitando maior efetivação das boas práticas de manipulação de alimentos no âmbito escolar.
FRAGMENTOS DE MIRZA GHALIB
Authors: Lucchesi Marco 
Published: June 2024

Mirza Ghalib (1797–1869) é um dos maiores poetas do subcontinente asiático. Fui tomado pela sua obra, que se divide fortemente entre o persa, o urdu e o hindi (dentro de um solo comum, entre as duas últimas: o hindustâni). A tradução que realizamos do original (urdu) segue em estado de laboratório. Sinais de percurso, talvez, plano-piloto para um work in progress, quase o avesso de um semblante. Um sentimento-ideia que aos poucos se elabora. A decisão de traduzi-lo deu-se nas colinas de Margalla, em Islamabad, com o admirável amigo Yousuf Khushk, a quem dedico os fragmentos de Ghalib.
Alternatywne spojrzenie na rolę Deweloperskiego Funduszu Gwarancyjnego
Authors: Kujawski Krzysztof 
Published: June 2024

W roku 2021 uchwalono ustawę o ochronie praw nabywcy lokalu mieszkalnego lub domu jednorodzinnego oraz Deweloperskim Funduszu Gwarancyjnym. Nowe rozwiązania ustawowe mają za zadanie poprawić skuteczność ochrony nabywców lokali mieszkalnych lub domów jednorodzinnych dokonujących tego typu czynności z udziałem dewelopera, poprawić bezpieczeństwo obrotu prawnego przy wzroście poziomu akceptacji regulacji po stronie przedsiębiorców. W artykule dokonano przeglądu środków ochrony oferowanej nabywcom lokali mieszkalnych lub domów jednorodzinnych w rozumieniu ustawy deweloperskiej ze szczególnym uwzględnieniem zabezpieczenia oferowanego w ramach Deweloperskiego Funduszu Gwarancyjnego oraz sytuacji związanej z niewypłacalnością dewelopera. Autor przedstawia alternatywną i poszerzoną koncepcję wykorzystania środków pochodzących z Deweloperskiego Funduszu Gwarancyjnego.
A SYSTEMATIC REVIEW AND META-ANALYSIS: RISK FACTORS OF MORTALITY COVID-19
Authors: Febrianti Thresya , Falmuriat Qurratu 
Published: June 2024

Background: COVID-19 is still a threat throughout the world because of its high morbidity and mortality. Comorbid diseases like hypertension, diabetes mellitus, and heart disease are some of the factors in the high severity and mortality of COVID-19 patients. Purpose: The study aims to analyze the effect of risk factors on COVID-19 mortality using a systematic review and meta-analysis. Methods: Articles were taken from online journal portals Pubmed, Garuda, and Google Cendekia, and all were published from October 2019 to December 2021 in full text and with an observational study design. The keywords used in searching the articles were "COVID-19", "sars cov 2", "2019-nCoV", "2019 novel coronavirus", "COVID-19 deaths", and "COVID-19 mortality". The articles were collected using a PRISMA diagram; then, data extraction was carried out in a systematic review. The data was synthesized by using a meta-analysis technique using the RevMan application. Results: This study analyzed 59 articles and found that age, hypertension OR=3.09 (2.69-3.56), sex OR= 1.29 (1.08-1.53), and diabetes mellitus OR=3.03 (2.66-3.44) are the risk factors for COVID-19 death. Conclusion: The death in COVID-19 patients is influenced by elderly age, gender, and comorbid disease (diabetes and hypertension). These COVID-19-death-related factors can help health workers recognize and prevent a more severe stage of the disease through more appropriate handling and treatment.
Pengetahuan dan Perilaku terkait Penggunaan Produk Pemutih Kulit pada Remaja Putri di Indonesia
Authors: Zumarthana Athallah Syauqi , Oktaviani Ni Kadek Dita , Imelda Viola Puspa , Putri Marsya Aretha , Kartikasari Yaasmiin , Sari Pepi Febrilia , Candraningsih Talitha Elysia , Rasyada Najmi Amrina , Ozora Mochammad Hakim , Idayati Dihan Isro’ , Kurniawan Thea Tifara Aisha , Yuda Ana 
Published: June 2024

Remaja diketahui mengalami perubahan fisik dan mental yang mendorong mereka untuk merawat diri dan menutupi kekurangan fisiknya, salah satunya dengan menggunakan produk pemutih kulit. Namun, masih terdapat produk pemutih ilegal yang beredar serta mengandung bahan berbahaya seperti merkuri, hidrokuinon, dan asam retinoat. Tujuan dari penelitian ini adalah untuk mengidentifikasi pengetahuan, dan perilaku penggunaan produk pemutih kulit pada remaja putri di Indonesia. Penelitian ini didesain sebagai penelitian observasional dan cross-sectional dengan teknik accidental sampling. Penelitian dilaksanakan dengan metode survei online menggunakan Google Form. Responden dalam penelitian adalah remaja putri berusia 17–24 tahun dan tidak memiliki latar belakang pendidikan kesehatan. Dari sebanyak 362 responden berpartisipasi pada survei ini, hampir separuh responden (44%) memiliki persepsi bahwa kulit yang putih terlihat lebih cantik dan sehat. Tingkat pengetahuan mayoritas responden tentang produk pemutih tergolong tinggi (93,6%). Lebih dari 60% responden berperilaku baik dengan tidak pernah dan sangat jarang membeli produk pemutih yang berefek instan serta terbiasa memeriksa legalitas produk di website BPOM. Meski begitu, beberapa responden tidak mengetahui regulasi BPOM tentang bahan penyusun pemutih berbahaya beserta efek sampingnya. Selain itu, sekitar 40% responden mendapatkan informasi dari media sosial maupun membeli produk pemutih di toko online. Dari penelitian ini, dapat disimpulkan bahwa pengetahuan, dan perilaku terkait produk pemutih kulit dari remaja putri Indonesia masih perlu ditingkatkan sehingga edukasi khususnya terkait bahan berbahaya dalam produk pemutih perlu dilakukan.
Development and Characterization of Polymeric-based Biomaterial from Agro-food Waste: A Sustainable and Eco-friendly Approach Towards Plastic Pollution
Authors: Hussain Rabbia , Aziz Athar , Amin Rashid , Khurshid Asma 
Published: June 2024

Introduction:
Commercial plastics are potentially hazardous and can be carcinogenic
due to the incorporation of chemical additives along with other additional components utilized
as brominated flame retardants and phthalate plasticizers during production that excessively
produce large numbers of gases, litter, and toxic components resulting in environmental pollution.

Methods:
Biodegradable plastic derived from natural renewable resources is the novel, alternative,
and innovative approach considered to be potentially safe as a substitute for traditional synthetic
plastic as they decompose easily without causing any harm to the ecosystem and natural
habitat. The utilization of undervalued compounds, such as by-products of fruits and vegetables
in the production of biodegradable packaging films, is currently a matter of interest because of
their accessibility, affordability, ample supply, nontoxicity, physiochemical and nutritional
properties. Industrial food waste was processed under controlled conditions with appropriate
plasticizers to extract polymeric materials. Biodegradability, solubility, and air test analysis were
performed to examine the physical properties of polymers prior to the characterization of the
biofilm by Fourier-transformed infrared spectroscopy (FTIR) for the determination of polymeric
characteristics.

Results:
The loss of mass examined in each bioplastic film was in the range of 0.01g to 0.20g.
The dimension of each bioplastic was recorded in the range of 4.6 mm to 28.7 mm. The existence
of -OH, C=C, C=O stretching, and other crucial functional groups that aid in the creation of
a solid polymeric material are confirmed by FTIR analysis. This study provides an alternative
approach for sustainable and commercially value-added production of polymeric-based biomaterials
from agro-industrial waste as they are rich in starch, cellulose, and pectin for the development
of bio-plastics.

Conclusion:
The rationale of this project is to achieve a straightforward, economical, and durable
method for the production of bio-plastics through effective utilization of industrial and
commercial fruit waste, ultimately aiding in revenue generation.
Anti-arthritic Activity and Anti-inflammatory Mediators Modulation
Effect of Bioactive Traditional Chaturbeeja Churna on Arthritis
Experimental Model
Authors: Sharma Vikash , Shukla Shiv Shankar , Gidwani Bina , Pandey Ravindra Kumar 
Published: June 2024

Objectives:
The purpose of this research was to determine whether or not Chaturbeeja
Churnam (CC) had anti-arthritic properties and the effect it has on Wistar rats that have been induced
with arthritis using Complete Freund's Adjuvant (CFA).

Methods:
Injection of 0.2 milliliters of CFA into the sub-plantar surface of the left hind paw resulted
in the development of arthritis. The test samples CC-1 and CC-2 were administered to the
animals for a period of 21 days in a row. After the arthritis was induced, the rise in swelling that
was noticed was observed. The blood samples that were taken were then used in additional testing
with a hematology analyzer to determine the number of red blood cells (RBC), white blood cells
(WBC), erythrocytes sedimentation rate (ESR), and hemoglobin (Hb). Using rat ELISA kits, the
levels of IL-6 and TNF- that were found in the serum were also analyzed.

Results:
CC showed a significant inhibitory effect in the protein denaturation assay. Results
showed that a significant reduction in paw edema was observed in CC-2 treated rats. The maximum
anti-inflammatory activity (59.12%) of the CC was noticed at a dose level of 400 mg/kg.
The paw edema was restored on day 21 was 4.52 mm for CC-2, which is near to the control
group. The arthritis score in treated rats was found to be considerably lower than in the control
group i.e. 0.92 for CC-2 and 1.61 for CC-1. A decrease in levels of RBC and hemoglobin was
observed in arthritic rats. Inflammation was significantly reduced and serum levels of IL-6 and
TNF-α were lowered after treatment with the test drug.

Conclusion:
It can be concluded from the study that CC possess significant anti-arthritic activity.
Furthermore, this condition was linked to a reduction in abnormal humoral immune responses.
Potential Mechanism by which Eriodictyol Protects against Doxorubicininduced
Cardiotoxicity based on Network Pharmacology, Molecular
Docking, and Molecular Dynamics Simulation
Authors: Qin Chunmeng , Sun Mei , Lv Feng , Du Dan , Li Wenjun , Liu Songqing 
Published: June 2024

Background:
The clinical use of doxorubicin (DOX), an anthracycline antibiotic
with broad-spectrum applications against various malignant tumors, is limited by doxorubicininduced
cardiotoxicity (DIC). Eriodictyol (ERD) has shown cardioprotective effects, but the
mechanism of its protective effect on DIC remains unknown.

Aims:
This study aimed to explore the potential mechanisms by which ERD confers protection
against DIC.

Methods:
ERD and DIC targets were identified from the TCMSP, PharmMaper, SwissTargetPrediction,
TargetNet, BATMAN, GeneCards, and PharmGKB databases. Differential gene
expression data between DIC and normal tissues were extracted from the GEO database. A protein‒
protein interaction (PPI) network of the intersecting ERD-DIC targets was constructed using
the STRING platform and visualized with Cytoscape 3.10.0 software. Gene Ontology (GO)
functional enrichment analysis and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway
enrichment analysis for ERD-DIC cross-targets were conducted. Validation included molecular
docking with AutoDock Tools software and molecular dynamics simulations with
Gromacs 2019.6 software.

Results:
Network pharmacology analysis revealed 43 intersecting ERD-DIC targets, including 6
key targets. GO functional enrichment analysis indicated that the intersecting targets were enriched
in 550 biological processes, 45 cell components, and 41 molecular functions. KEGG
pathway enrichment analysis identified 114 enriched signaling pathways. Molecular docking
revealed a strong binding affinity between ERD and 6 key targets, as well as multiple targets
within the ROS pathway. Molecular dynamics simulations indicated that ERD has favorable
binding with 3 crucial targets.

Conclusion:
The systematic network pharmacology analysis suggests that ERD may mitigate
DIC through multiple targets and pathways, with the ROS pathway potentially playing a crucial
role. These findings provide a reference for foundational research and clinical applications of
ERD in treating DIC.

conclusion:
Systematic network pharmacology analysis suggests that ERD may mitigate DIC through multiple targets and pathways, with the ROS pathway potentially playing a crucial role. These findings provide references for foundational research and clinical applications of ERD in treating DIC.
Arsenic Trioxide Suppresses Angiogenesis in Non-small Cell Lung Cancer via the Nrf2-IL-33 Signaling Pathway
Authors: Wang Mingdong , Yin Jizhong , Han Qianyu , Li Bing , Zhao Xue-Wei , Xue Lei 
Published: June 2024

Background:
Non-Small Cell Lung Cancer (NSCLC) ranks as a leading cause of cancer-related mortality,
necessitating the urgent search for cost-effective and efficient anti-NSCLC drugs. Our preliminary research
has demonstrated that arsenic trioxide (ATO) significantly inhibits NSCLC angiogenesis, exerting anti-tumor
effects. In conjunction with existing literature reports, the Nrf2-IL-33 pathway is emerging as a novel mechanism
in NSCLC angiogenesis.

Objective:
This study aimed to elucidate whether ATO can inhibit NSCLC angiogenesis through the Nrf2-IL-33
pathway.

Methods:
Immunohistochemistry was employed to assess the expression of Nrf2, IL-33, and CD31 in tumor
tissues from patients with NSCLC. DETA-NONOate was used as a nitric oxide (NO) donor to mimic high levels
of NO in the tumor microenvironment. Western blot, quantitative real-time PCR, and enzyme-linked immunosorbent
assay were utilized to evaluate the expression of Nrf2 and IL-33 in the NCI-H1299 cell line. Subcutaneous
xenograft models were established in nude mice by implanting NCI-H1299 cells to assess the anti-tumor
efficacy of ATO.

Results:
High expression levels of Nrf2 and IL-33 were observed in tumor samples from patients with NSCLC,
and Nrf2 expression positively correlated with microvascular density in NSCLC. In vitro, NO (released from
1mM DETA-NONOate) promoted activation of the Nrf2-IL-33 signaling pathway in NCI-H1299 cells, which
was reversed by ATO. Additionally, both Nrf2 deficiency and ATO treatment significantly attenuated NOinduced
IL-33 expression. In vivo, both ATO and the Nrf2 inhibitor ML385 demonstrated significant inhibitory
effects on angiogenesis tumor growth.

Conclusion:
Nrf2-IL-33 signaling is usually activated in NSCLC and positively correlates with tumor angiogenesis.
ATO effectively disrupts the activation of the Nrf2-IL-33 pathway in NSCLC and thus inhibits angiogenesis,
suggesting its potential as an anti-angiogenic agent for use in the treatment of NSCLC.
Open Innovation or Traditional Patenting Strategies to Efficiently Address Health Emergencies: How Patent Information was used Towards Effective Treatments for COVID-19
Authors: de Almeida Tatiana Duque Martins Ertner , Cordeiro Diericon Sousa 
Published: June 2024

Introduction/Objective:
During the 1150 days of COVID-19 pandemic there
were great efforts to develop efficient treatments for the disease. After this long time,
some drugs emerged as treatment for COVID-19. Some of them are new drugs, most of
them, known drugs. These developments were triggered by information already available
in patent documents. Pharmaceutical companies, therefore, rushed to conduct drugs evaluations
and trials in order to deliver to the world a reasonable treatment that could reach
the majority of its population. However, it is not immediately clear how companies operated
to reach their goals. The ability of open innovation to achieve results assertively and
faster than closed innovation strategies is questioned and therefore, it is questioned
whether pharmaceutical companies use open innovation to face COVID-19.

Methods:
In this work, data available on patent databases were mined to inform about
the scientific and technological panorama of selected drugs tested for COVID-19 treatment
and to understand the perspectives of such developments during the pandemic.

Results:
This study evidenced that most treatments were based on known drugs, that
some of the initially promising drugs were abandoned during the pandemic, and that it
was able to inform if open innovation and collaborations were explored strategies.

Conclusion:
This study evidenced that the developments during COVID-19 were not
based on open innovation by revealing a patent race towards the treatment development,
but with practically no collaborations or information exchange between companies, universities,
and research facilities.