bluuebunny/crossref_metadata_2025_split huggingface dataset:
Food antibodies in acute psychoses
Authors: Rix K. J. B. , Ditchfield Janet , Freed D. L. J. , Goldberg D. P. , Hillier Valerie F. 
Published: July 2009

SynopsisAntibodies to a variety of foods, and in particular cereals, were measured in serum from 100 patients with acute psychoses and 100 elective surgical patients. For 13 out of 14 foods to which non-IgE antibodies were detected the schizophrenics had slightly more antibodies than the controls. There was an association between a possible secondary mania and the presence of IgE antibodies to wheat or rye. However, neither the schizophrenia nor the mania findings can be regarded as evidence for food allergy causing psychiatric disorder, since the immunological findings in both cases may represent consequences of the illnesses or their treatment, rather than causes of the illness.
A study of the classification of mental ill-health in general practice
Authors: Jenkins Rachel , Smeeton Nigel , Marinker Marshall , Shepherd Michael 
Published: July 2009

SynopsisAn outline is provided of an experimental study of the classification of mental ill-health presented to general practitioners (GPs). Videotaped real-life consultations were assessed by 27 GPs for the purpose. A high degree of inter-observer variation was recorded. Some of the implications of the findings are discussed.
Validation of the Italian version of the GHQ in a general practice setting
Authors: Fontanesi F. , Gobetti C. , Zimmermann-Tansella Ch. , Tansella M. 
Published: July 2009

SynopsisThe 30-item General Health Questionnaire (GHQ) and the Clinical Interview Schedule (CIS) were administered to 120 consecutive attendere at a general practice in Northern Italy run by a doctor who had a formal psychiatric training. The Italian versions of both the GHQ and the CIS were found to be feasible instruments for general practice studies in Italy. GHQ misclassification rates, sensitivity and specificity values are presented for different cut-off scores, a total score of 5 or more being the best discriminator between ‘cases’ and ‘non-cases’. The prevalence of confirmed cases in this sample was 47·5%, a rate higher than those reported so far in developed and developing countries.
A doctor's dilemma: the case of William Harvey's mentally retarded nephew
Authors: Neugebauer Richard 
Published: July 2009

SynopsisIn June 1637 William Harvey petitioned the Court of Wards and Liveries, a legal incompetency court in early modern England, for a grant of the custody of his mentally disabled nephew, William Fowke. ‘Idiocy’ and ‘lunacy’ were the two medico-legal categories for insanity used by the Court and Harvey requested that his nephew be inspected for idiocy. However, the legal and administrative history of the Court indicates that in the 1630s idiocy (but not lunacy) grants were prejudicial to the assets and economic security of retarded persons. Since petitioners' wishes, more than clinical status, usually determined the diagnostic label assigned to referred individuals, idiocy grants were not sought by persons of some social standing. Harvey's idiocy referral probably reflects his allegiance to his own clinical observations in the face of opposing social norms and family advantage.
Structural brain CT changes and cognitive deficits in elderly depressives with and without reversible dementia (‘pseudodementia’)
Authors: Pearlson Godfrey D. , Rabins Peter V. , Kim Won S. , Speedie Lynn J. , Moberg Paul J. , Burns Alistair , Bascom Mary J. 
Published: July 2009

SynopsisTwenty-six elderly (> 60 yrs) patients with DSM-III major depression were compared to 13 patients with NINCDS/ADRDA probable Alzheimer's disease (AD), and to 31 screened normal controls. Subjects were matched on age and sex. Fifteen of the 26 depressed patients were cognitively impaired on the Mini-Mental State Examination (MMSE) upon admission, but after treatment returned to the normal range. These 15 patients were defined as having the dementia syndrome of depression (DOD). The remaining 11 depressed patients were termed depressed, cognitively normal (DCN). All subjects received standardized cranial CT scans for assessment of ventricular brain ratio (VBR) and CT attenuation numbers. Subjects also received neuropsychological evaluation.CT values for the 26 depressed patients lay between those of AD patients and normal controls. CT values for the DOD subgroup clustered near those of AD patients. Patterns of cognitive deficits and correlations of CT attenuation values with cognitive measures were also similar in AD and DOD. Most patients were reassessed at a mean of two years after initial testing; of the 11 of the 15 DOD re-examined, only one had undergone cognitive decline. By contrast, all AD patients retested had declined significantly. Episodes of DOD and DCN tended to ‘breed true’. This study suggests that while patients with DOD may have underlying structural brain abnormalities, obvious short-term progression to AD does not commonly occur.
Effects of light treatment upon mood and melatonin in patients with seasonal affective disorder
Authors: Winton F. , Corn T. , Huson L. W. , Franey C. , Arendt J. , Checkley S. A. 
Published: July 2009

SynopsisTen patients with seasonal affective disorder received the following treatments for 5 days each: (a) artificial daylight (2500 lux) from 20.00 to 23.00 and from 07.00 to 10.00 hours; (b) red light (300 lux) from 20.00 to 23.00 and from 07.00 to 10.00 hours; (c) artificial daylight (2500 lux) from 22.00 to 23.00 and from 07.00 to 08.00 hours. The antidepressant effect of treatment (a) was superior to that of treatment (b), suggesting that the effect of light treatment in winter depression is more than that of a placebo. The antidepressant effect of treatment (a) was superior to that of treatment (c), although these two treatments equally suppressed plasma melatonin concentrations. Consequently, in these patients there is a dissociation between the effect of light treatment on melatonin and the reduction of depression ratings.
Is puerperal psychosis the same as bipolar manic-depressive disorder? A family study
Authors: Dean C. , Williams R. J. , Brockington I. F. 
Published: July 2009

SynopsisThe first degree relatives of three groups of women were interviewed; 51 women who had had an illness within two weeks of childbirth and no non-puerperal episodes (the puerperal group), 33 who had puerperal and non-puerperal episodes (the mixed group), and 19 women with bipolar manic-depressive disorder who had non-puerperal episodes only (the manic-depressive group).Over 60% of the affected relatives in all three groups had affective illnesses; in the main these were not puerperal. There were significantly more first degree relatives who had had general practitioner or hospital treatment for psychiatric illness in the puerperal group and in the mixed group than in the manic-depressive group. The puerperal patients had a better prognosis in terms of their illness (number of relapses and time on medication), work functioning and social functioning than the manic-depressive group and the mixed group. The mixed group had an earlier age of onset than the manic-depressive group and the puerperal group. The hypothesis that puerperal psychosis is the same as bipolar manic-depressive disorder was not upheld. The mixed group and the puerperal group were similar with respect to the risk in first degree relatives but differed in terms of prognosis.There were no significant differences between the groups with respect to puerperal episodes in first-degree relatives, although the rate of puerperal psychosis in the first-degree relatives of the puerperal patients was significantly greater than in the general population. The hypothesis that there is a specific genetically determined puerperal psychosis was not supported. Women who had had an illness with an onset within two weeks of childbirth (mixed and puerperal) subsequently had an illness following 36% of their childbirths. In women who had had puerperal and non-puerperal episodes (mixed) the risk was higher; over 50 % of deliveries in these women were followed by psychiatric illness.
Psychiatric cases: an ethnography of the referral process
Authors: Morgan David 
Published: July 2009

SynopsisInvestigation into the referral histories of a consecutive series of new patients attending two psychiatric out-patient clinics questioned the assumption that only the more severe and problematic cases are selected by general practitioners for specialist referral. In 40% of cases, clinical indications only became decisive in relation to emergent difficulties in managing the case, while 38% of patients or their relatives requested referral. The implications of these observations are considered in relation to alternative models of psychiatric intervention in the management of psychosocial disorders in primary care.
Memory and ventricular size in alcoholics
Authors: Acker C. , Jacobson R. R. , Lishman W. A. 
Published: July 2009

SynopsisThe relationship between memory performance and CT scan measures of ventricular size was investigated in a sample of 39 chronic alcoholics and 39 controls. Measures of verbal, non-verbal, recognition and recall memory were derived from the tests administered and were viewed in relation to the lateral ventricle and third ventricular size measurements. The results showed that the memory performance of male alcoholics was significantly related to measures of third ventricular size, but probably not to measures of the lateral ventricles. An association between verbal memory performance and CT scan measures was found in the male controls.
Cognitive brain potentials and psychological deficits in Alzheimer's dementia and Korsakoff's amnesic syndrome
Authors: Blackwood D. H. R. , St Clair D. M. , Blackburn I. M. , Tyrer G. M. B. 
Published: July 2009

SynopsisAuditory-event-related potentials, including the P300 response, were recorded from 20 patients with Aizeheimer-type dementia (ATD), 17 patients with Korsakoff's syndrome (KS) and 23 age-matched control subjects. Each of the subjects was assessed using a version of the Luria Neuropsychological Investigation. Prolonged P300 latency and reduced P300 amplitude, which are features of normal ageing and which also occur, to a greater degree, in ATD, correlated significantly with degree of impairment of language ability in both Alzheimer patients and controls. On the other hand, the association between P300 latency changes and various tests of memory was not consistent across the three subject groups; there was a significant negative correlation between P300 latency and visual memory in ATD and a significant positive correlation in KS, whereas in controls no significant correlation was found. By contrast, P300 latency and memory for words were significantly negatively correlated in controls, but in neither of the patient groups.Detailed studies of language function may further elucidate the complex relationships between neuropsychological measures and P300 changes in normal ageing and dementia.
Cognitive dysfunction in melancholia
Authors: Abrams Richard , Taylor Michael Alan 
Published: July 2009

SynopsisSixty-seven patients with melancholia and 42 normal controls were tested with a battery of neuropsychological tasks selected to assess regional cortical functioning in both hemispheres. Compared with controls, melancholics exhibited a pattern of bifrontal and right parietal impairment, which was independent of age, sex, handedness and drug administration. These findings confirm and extend prior studies and contrast with those we and others have reported in patients with schizophrenia.
Stress, immunity and illness — a review
Authors: Dorian Barbara , Garfinkel Paul E. 
Published: July 2009

SynopsisPsychological factors have long been thought to play a contributing role in either the predisposition, onset or course of various physical illnesses. Recently, rapid advances in immunology have created interest in the interaction between psychosocial factors, behaviour and the immune system. This paper reviews some of the models proposed to explain the relationship between psychological variables and physical illness and presents evidence for a contribution of psychological factors to certain illnesses in which abnormalities in immunologic state are thought to be important. From a somewhat different perspective, animal studies have demonstrated complex effects of stress, on disease susceptibility. Recent human studies have demonstrated consistent immunologic changes in people undergoing acute naturally occurring psychological stress such as bereavement or an important examination. In humans, the effects of chronic stress may be different from acute stress, corresponding to the findings in animals. Abnormalities in immunologic functioning and physical illness are reviewed for different psychiatric disorders — depression, anorexia nervosa and schizophrenia; depression is the only disorder which consistently demonstrated immunologic changes. Possible mechanisms for the stress/immune-change relationship are suggested.
Symptomatology, psychosexual development and gender identity in 42 anorexic males
Authors: Fichter M. M. , Daser C. 
Published: July 2009

SynopsisForty-two male patients with an anorexic syndrome were assessed. Twenty-nine of them had a primary anorexia nervosa (most of them also had bulimic symptoms). They were compared with a series of 23 female anorexia nervosa patients. The males scored more highly than female patients on a number of symptoms, but generally more similarities than differences in symptomatology were apparent. Male patients with primary anorexia nervosa also showed several signs of a disturbed psychosexual and gender identity development. The data support the hypothesis that males with atypical gender role behaviour have an increased risk for developing anorexia nervosa or bulimia in adolescence.
A longitudinal study of social support and depression in unemployed men
Authors: Bolton Winifred , Oatley Keith 
Published: July 2009

SynopsisInterviews were conducted with 49 men just after they had become unemployed, and with a matched sample of 49 employed men. Follow-up interviews took place 6–8 months later. At follow-up 20 originally unemployed men were still without work, and were significantly more depressed than the employed. Five of these 20, but no employed men, had become clinically depressed. In a multiple regression analysis there was a significant employment × social support interaction which indicated that depression scores at follow-up were higher in those who remained unemployed and who had little social contact with others in the month before losing their jobs. Depression becomes likely when people lose a source of social interaction that is important to their sense of worth, and have no alternative means of experiencing this worth in other relationships.
Regional cerebral blood flow in depression measured by positron emission tomography: the relationship with clinical dimensions
Authors: Bench C. J. , Friston K. J. , Brown R. G. , Frackowiak R. S. J. , Dolan R. J. 
Published: July 2009

SynopsisWe have previously reported focal abnormalities of regional cerebral blood flow (rCBF) in a group of 33 patients with major depression. This report, on an extended sample of 40 patients who demonstrated identical regional deficits to those previously described, examines the relationships between depressive symptoms and patterns of rCBF. Patients' symptom ratings were subjected to factor analysis, producing a three-factor solution. The scores for these three factors, which corresponded to recognizable dimensions of depressive illness, were then correlated with rCBF. The first factor had high loadings for anxiety and correlated positively with rCBF in the posterior cingulate cortex and inferior parietal lobule bilaterally. The second factor had high loadings for psychomotor retardation and depressed mood and correlated negatively with rCBF in the left dorsolateral prefrontal cortex and left angular gyrus. The third factor had a high loading for cognitive performance and correlated positively with rCBF in the left medial prefrontal cortex. These data indicate that symptomatic specificity may be ascribed to regional functional deficits in major depressive illness.
The Edinburgh cohort of HIV-positive drug users: the relationship between auditory P3 latency, cognitive function and self-rated mood
Authors: Egan V. G. , Chiswick A. , Brettle R. P. , Goodwin G. M. 
Published: July 2009

SynopsisOne hundred and six HIV-positive drug users were tested with a two-tone auditory evoked potential (AEP) task and a small battery of neuropsychological tests, to examine the relationship between the latency of the P300 component (P3) of the AEP, intellectual function, mood and drug use. Principal components analysis revealed a significant correlation between P3 latency and the first principal component (r = −0·43, P < 0·001). Varimax rotation generated three orthogonal components which we interpreted as intellectual performance, memory, and mood. Intellectual performance and self-reported mood were individually correlated with P3 latency, but memory was not (r = −0·36, P < 0·001; r = 0·23, P < 0·05; and r = −0·18, NS, respectively).Subjects with symptomatic HIV disease had a higher correlation between P3 latency and intellectual performance than subjects with asymptomatic HIV disease and, among patients with symptomatic HIV disease, poorer memory was associated with a lower CD4 count. Opiate or benzodiazepine consumption did not correlate with poor intellectual performance, memory, or selfrated mood in our sample. These results indicate that there is a relationship between AEP latency and neuropsychological measures of intellectual function, and that it is influenced by subjective mood. Surprisingly, declared current drug use has no discriminable effect on these relationships.
War-induced prolonged stress and metabolic control in Type 2 diabetic patients
Authors: Pibernik-Okanović Mirjana , Roglić Gojka , Prašek Manja , Metelko Željko 
Published: July 2009

SynopsisSound evidence that psychological stress may significantly worsen metabolic control in diabetic patients is lacking. The stressful effects of war on glycaemia control have not been assessed as yet. A randomly selected sample of displaced Type 2 diabetic persons (N= 44) was compared to a matched group of diabetic persons who had not been forced to leave their homes. The self-reported stress, depression level, fasting and post-prandial blood glucose, glycosylated haemoglobin and serum lipids were compared. The two groups were found to be significantly different in scores for self-reported stress and depression levels (P< 0·001). The proportion of subjects belonging to the category of clinically significant depression was larger in the group of displaced persons (P< 0·001), as well as the proportion of extreme scores for self-reported stress (P< 0·001). No significant differences between the groups were found for variables measuring metabolic control (P> 0·05), except for the serum triglycerides which were found to be significantly higher in the group of displaced persons (P< 0·01). This is assumed to be the result of differences in nutrition. The results do not demonstrate an association between prolonged stress and glycaemic control in Type 2 diabetic patients. The variability of data measuring stress and depression level in two extreme groups with respect to HbA1cvalues suggests that individual factors which determine the response to stressors need to be explored.
Psychosocial stress and breast cancer: the inter-relationship between stress events, coping strategies and personality
Authors: Cooper Cary L. , Faragher E. Brian 
Published: July 2009

SynopsisThis quasi-prospective study of 2163 women attending a breast-screening clinic for a routine medical check-up indicates that certain types of coping strategies and personality dispositions predispose some women to an increased risk of developing breast cancer following the occurrence of a major life-event such as bereavement or other loss-related event. Regular exposure to stress situations appears to reduce the risk of a malignancy; experiencing a single, major life event was found to be potentially much more damaging, particularly if the individual was unable to externalize her emotions and obtain appropriate help and counselling.
Childhood adversities and adult depression: basic patterns of association in a US national survey
Authors: Kessler Ronald C. , Magee William J. 
Published: July 2009

SynopsisThe long-term relationships between various forms of childhood adversity and adult episodes of major depression are explored in a representative household survey of the United States adult (age 25 +) population. Seven of the eight childhood adversities considered are significantly associated with recent (12-month) episodes of depression. These effects are largely indirect consequences of some childhood adversities leading to a life history of depression and prior depression leading to new episodes. Only three of the eight childhood adversities directly affect recent onset or recurrence. The paper closes with a discussion of implications for future research on the long-term effects of childhood adversities.
Perceived health and high consumers of care: a study of mental health problems in a Swedish primary health care district
Authors: Borgquist L. , Hansson L. , Nettelbladt P. , Nordström G. , Lindelöw G. 
Published: July 2009

SynopsisMany patients with mental health problems are treated in primary health care services. They are often multi-users of care. In the present investigation we have studied patients visiting primary health care clinics who have been assessed for mental health problems according to the Hopkins Symptom Check List (HSCL-25). Two quality-of-life instruments (the Nottingham Health Profile and the Mood Adjective Check List) were applied to describe further the perceived health of the sample.A random sample of 93 patients was chosen out of 388 patients visiting a primary health care clinic in a Swedish health care district during four weeks in January and February 1990, and these patients were followed prospectively during one year. High consumers of health care during the follow-up period scored a poor perceived health. ‘Feeling worthless’, predicted a high number of days of sickness absenteeism. Hidden cases, not detected by the GPs, consumed more resources than those identified by the GPs. The importance of training and educating general practitioners in the early detection of patients with mental health problems is discussed.
Frontal lobe impairment in schizophrenia: relationship to intellectual functioning
Authors: Crawford J. R. , Obonsawin M. C. , Bremner M. 
Published: July 2009

SynopsisSchizophrenic subjects (N = 48) and individually matched healthy controls were administered the Verbal Scale of the Wechsler Adult Intelligence Scale (VIQ) and a test of verbal fluency. The verbal fluency and VIQ scores of the schizophrenic subjects were significantly lower than the scores of the control subjects. An additional sample of healthy subjects (N = 144) was used to generate a regression equation for the prediction of verbal fluency scores from Verbal IQ and age. The verbal fluency scores obtained by the schizophrenic subjects were significantly lower than the scores predicted from the regression equation, whereas a significant difference was not obtained in the matched controls. These results provide further evidence of frontal lobe dysfunction in schizophrenia.