bluuebunny/crossref_metadata_2025_split huggingface dataset:
Development, reliability, and validity of the posttraumatic stress disorder interview for vietnamese refugees: A diagnostic instrument for vietnamese refugees
Authors: Dao Tam K. , Poritz Julia M. P. , Moody Rachel P. , Szeto Kim 
Published: July 2012

AbstractThe Posttraumatic Stress Disorder Interview for Vietnamese Refugees (PTSD‐IVR) was created specifically to assess for the presence of current and lifetime history of premigration, migration, encampment, and postmigration traumas in Vietnamese refugees. The purpose of the present study was to describe the development of and investigate the interrater and test‐retest reliability of the PTSD‐IVR and its validity in relation to the diagnoses obtained from the Longitudinal, Expert, and All Data (LEAD; Spitzer, 1983) standard. Clinicians conducted the diagnosis process with 127 Vietnamese refugees using the LEAD standard and the PTSD‐IVR. Assessment of the reliability and validity of the PTSD‐IVR yielded good to excellent AUC (area under the receiver operating characteristic curve; .86, .87) and κ values (.66, .74) indicating the reliability of the PTSD‐IVR and the agreement between the LEAD procedure and the PTSD‐IVR. The results of the present study suggest that the PTSD‐IVR performs successfully as a diagnostic instrument specifically created for Vietnamese refugees in their native language.
The structure of peritraumatic dissociation: A cross validation in clinical and nonclinical samples
Authors: Sijbrandij Marit , Engelhard Iris M. , Opmeer Brent C. , van de Schoot Rens , Carlier Ingrid V. E. , Gersons Berthold P. R. , Olff Miranda 
Published: July 2012

AbstractEmpirical data have challenged the unidimensionality of the Peritraumatic Dissociative Experiences Questionnaire (PDEQ), a widely used measure for peritraumatic dissociation. The aim of this study was to assess the factor structure of the PDEQ in 3 trauma‐exposed samples: (a) trauma‐exposed police officers (N = 219); (b) trauma‐exposed civilians (N = 158); and (c) treatment‐seeking trauma‐exposed civilians (N = 185). Confirmatory factor analyses using measurement invariance testing supported a 2‐factor structure (CFIs .96–.98; RMSEAs .07–.09), but excluded 2 of the original items. Factor 1 was termed Altered Awareness; Factor 2 was termed Derealization. Altered Awareness reflected disturbances in information processing during the traumatic event, whereas Derealization reflected distortions in perception. Hierarchical linear regression analysis showed that Derealization predicted posttraumatic stress severity at 26.5 weeks follow‐up only in the sample of police officers (R2 = .45). Future longitudinal research shortly following trauma is required to elucidate causality and underlying mechanisms of peritraumatic dissociation, which may contribute to the development of more accurate screening strategies, as well as more effective strategies for prevention and early intervention.<?vsp ‐3.25pt?>
The influence of comorbid MDD on outcome after residential treatment for veterans with PTSD and a history of TBI
Authors: Walter Kristen H. , Barnes Sean M. , Chard Kathleen M. 
Published: July 2012

AbstractAmong military personnel, posttraumatic stress disorder (PTSD), major depressive disorder (MDD), and a history of traumatic brain injury (TBI) are frequently reported, highlighting the need for treatment outcome research with this population. This study examined the influence of the presence or absence of comorbid MDD on the outcome of a residential treatment program at the midpoint and end of the program for 47 male veterans with PTSD and a history of TBI. Results demonstrated significant decreases of self‐reported symptoms on the PTSD Checklist‐Stressor Specific Version (PCL‐S; MDD, d = 1.19; No MDD, d = 1.17) and the Beck Depression Inventory–II (BDI‐II; MDD, d = 0.98; No MDD, d = 1.09) following treatment for both groups. There were no differences in the rate of symptom reduction between groups. Individuals who also met criteria for MDD at pretreatment, however, evidenced higher scores on symptom measures at all assessment time points (ds = 0.60–1.25).
Multi‐loci analysis reveals the importance of genetic variations in sensitivity of platinum‐based chemotherapy in non‐small‐cell lung cancer
Authors: Liu Li , Wu Jing , Zhong Rong , Wu Chen , Zou Li , Yang Beifang , Chen Wei , Zhu Beibei , Duan Shengyu , Yu Dianke , Tan Wen , Nie Shaofa , Lin Dongxin , Miao Xiaoping 
Published: July 2012

AbstractPolymorphisms in DNA repair and apoptotic pathways may cause variations in chemosensitivity of non‐small‐cell lung cancer (NSCLC) through complex gene–gene and gene–environment interactions. A total of 200 advanced NSCLC patients who received platinum‐based chemotherapies were recruited. The short‐term clinical outcomes were classified as chemosensitive group, including complete remission (CR) and partial remission (PR), and chemoresistant group, namely stable disease (SD) and progression disease (PD) at the end of treatment. We applied multifactor dimensionality reduction (MDR), classification and regression tree (CART) and traditional logistic regression (LR) to explore high‐order gene–gene and gene–environment interactions among 11 functional single nucleotide polymorphisms (SNPs), smoking status, cancer stages and treatment regimens in the response to chemotherapy. Multi‐loci analyses consistently indicated that interactions among XRCC1 Arg194Trp, XPC PAT, FAS G–1377A, and FASL T–844C were associated with sensitivity to platinum‐based chemotherapy. In MDR analysis, the four‐factor model yielded the highest test accuracy of 0.72 (permutation P = 0.001). In CART analysis, these four SNPs were the determinant nodes of the growth of regression tree. Patients carrying XRCC1 Arg194Arg, FAS–1377GG, and FASL–844T allele displayed completely no response to platinum, whereas patients with XRCC1 194Trp allele and XPC PAT +/+ had 68.8% response rate to platinum. In LR analysis, a significant gene–dosage effect was detected along with the increasing number of favorable genotypes of these four polymorphisms (Ptrend = 0.00002). Multi‐loci analysis reveals the importance of genetic variations involved in DNA repair and apoptotic pathways in sensitivity of platinum‐based chemotherapy in NSCLC. © 2012 Wiley Periodicals, Inc.
A viable isolated tissue system: A tool for detailed MR measurements and controlled perturbation in physiologically stable tissue
Authors: Richardson S. , Siow B. , Batchelor A. M. , Lythgoe M. F. , Alexander D. C. 
Published: July 2012

AbstractIn vivo magnetic resonance imaging (MRI) assessment of neuronal tissue is prone to artifacts such as movement, pulsatile flow, and tissue susceptibility. Furthermore, stable in vivo scans of over 3 h are difficult to achieve, experimental design is therefore limited. Using isolated tissue maintained in a viable physiological state can mitigate many of these in vivo issues. This work describes the fabrication and validation of an MRI compatible viable isolated tissue maintenance chamber. Parameters measured from maintained rat optic nerves did not change significantly over 10 h: (i) mean axon radius [electron microscopy — 0 h: 0.75 ± 0.46; 5 h: 0.74 ± 0.35; 10 h: 0.76 ± 0.35 μm (P >> 0.05, t‐test], (ii) action potentials [grease‐gap electrophysiology − 4.89 ± 0.16 mv, (P >> 0.05, Pearson test], and (iii) diffusion tensor imaging parameters [fractional anisotropy: 0.86 ± 0.02 (P >> 0.05, Pearson test), mean diffusivity: 1.48E‐06 ± 9.74E‐08 cm2/s, (P >> 0.05, Pearson test)]. In addition, a thorough diffusion‐weighted MR protocol demonstrated the comparable stability of viable isolated and chemically fixed rat optic nerve. This MRI compatible viable isolated tissue system allows researchers to probe neuronal physiology in a controlled environment by limiting in vivo artifacts and allowing extended MRI acquisitions. Magn Reson Med, 2013. © 2012 The Authors Magnetic Resonance in Medicine published by Wiley Periodicals, Inc. on behalf of International Society for Magnetic Resonance in Medicine.
Phosphoglycerate mutase deficiency with tubular aggregates in a patient from panama
Authors: Salameh Johnny , Goyal Namita , Choudry Rabia , Camelo‐Piragua Sandra , Chong Peter Siao Tick 
Published: July 2012

AbstractIntroduction:Phosphoglycerate mutase deficiency (PGAM) is a rare metabolic myopathy that results in terminal block in glycogenolysis. Clinically, patients with PGAM deficiency are asymptomatic, except when they engage in brief, strenuous efforts, which may trigger myalgias, cramps, muscle necrosis, and myoglobinuria. An unusual pathologic feature of PGAM deficiency is the association with tubular aggregates.Methods:We report an African‐American patient from Panama with partial deficiency of PGAM who presented with asymptomatic elevation of creatine kinase levels and tubular aggregates on muscle biopsy.Results:Muscle biopsies showed subsarcolemmal and sarcolemmal tubular aggregates in type 2 fibers. Muscle PGAM enzymatic activity was decreased and gene sequencing revealed a heterozygous mutation in codon 78 of exon 1 of the PGAM2 gene, which is located on the short arm of chromosome 7.Conclusions:PGAM deficiency has been reported in 14 patients, 9 of whom were of African‐American ethnicity, and in 5 (36%) tubular aggregates were seen on muscle biopsy. Contrary to previously reported cases, our patient was initially asymptomatic. This further expands the PGAM deficiency phenotype. Muscle Nerve, 2013
Reasons for using swelling ratio in sonographic diagnosis of carpal tunnel syndrome and a reliable method for its calculation
Authors: Ulaşli Alper Murat , Duymuş Mahmut , Nacir Bariş , Rana Erdem Hatice , Koşar Uğur 
Published: July 2012

IntroductionThe aim of this study was to investigate factors affecting median nerve cross‐sectional area (CSA) and determine a dependable swelling ratio (SR) calculation method.MethodsUsing ultrasonography, median nerve CSAs were measured at the tunnel inlet, midtunnel, and outlet, and at 4 cm and 12 cm proximal to the wrist. We used CSAmax as the largest of the tunnel measurements and calculated swelling ratios (SRs) by using the CSAmax. Sonographic measurements were correlated with electrophysiologic findings. We evaluated the effects of gender, weight, and height on median nerve thickness.ResultsWe studied 95 wrists of 55 CTS patients and 48 wrists of 27 volunteers. Gender, weight, and height had effects on certain median nerve CSA measurements. CSAmax, SRmax4, and SRmax12 had superior correlations with electrophysiologic findings. The correlation between 4‐cm and 12‐cm median nerve CSAs was statistically significant (r = 0.879 and P < 0,001).ConclusionWe have developed a reliable SR method considering factors affecting median nerve CSA. Muscle Nerve 47:396‐402, 2013
Split least‐squares finite element methods for non‐Fickian flow in porous media
Authors: Rui Hongxing , Guo Hui 
Published: July 2012

AbstractIn this article, we introduce two least‐squares finite element procedures for parabolic integro‐differential equations arising in the modeling of non‐Fickian flow in porous media. By selecting the least‐squares functional properly the presented procedure can be split into two independent subprocedures, one subprocedure is for the primitive unknown and the other is for the flux. The optimal order convergence analysis is established. Numerical examples are given to show the efficiency of the introduced schemes. © 2012 Wiley Periodicals, Inc. Numer Methods Partial Differential Eq, 2013
Photostabilizing efficiency of ultraviolet light stabilizers for rigid poly(vinyl chloride) against photo‐oxidation
Authors: Zhang Xiaofei , Pi Hong , Guo Shaoyun 
Published: July 2012

AbstractThe photostabilizing efficiency of different light stabilizers in poly(vinyl chloride) (PVC) was investigated by discoloration, ultraviolet (UV) reflection experiment, Fourier transform infrared spectrum (FTIR), and scanning electron microscopy (SEM). The results show that the addition of light stabilizers can slow down discoloration of PVC. The UV reflection results verify that this change is due to the distribution of light stabilizers on irradiated surfaces, which can absorb (such as organic stabilizers) or reflect (such as titanium dioxide) UV light differently. The order of stabilizers that can slower the extent of discoloration is titanium dioxide (TiO2) > Tinuvin 234 (U4) > XT 833 (H2), U4 > Tinuvin 531 (U3) > Chimassorb 944 (H1), phenyl salicylate (U1). FTIR results show that the carbonyl group of pure PVC, TiO2, and H1‐doped PVC increases significantly, indicating that the photo‐oxidation reactions of these irradiated samples are relatively serious. The SEM results show that the surface damages of PVC doped with U2, U4, and H2 are somehow slighter, with only small holes or cavities on the surface, whereas the surfaces of pure PVC and H1‐doped PVC are full of big and deep holes and some holes or cavities of 10 μm are detected. POLYM. ENG. SCI., 2013. © 2012 Society of Plastics Engineers
High impact poly(lactic acid)/poly(ethylene octene) blends prepared by reactive blending
Authors: Feng Yulin , Hu Yuexin , Yin Jinghua , Zhao Guiyan , Jiang Wei 
Published: July 2012

AbstractPoly(ethylene octene) grafted with glycidyl methacrylate (POE‐g‐GMA) was prepared and used to toughen poly (lactic acid) (PLA) via reactive blending. It was found that the notched Izod impact strength of PLA/POE‐g‐GMA blends improved dramatically when the content of elastomer was higher than 10 wt%. Reactive compatibilization between PLA and POE‐g‐GMA were studied by Fourier transform infrared spectroscopy (FTIR) and “Molau test,” the results showed the end carboxyl groups of PLA reacted with the epoxide groups of POE‐g‐GMA during blending. This considerably improved the compatibilization, leading to better wetting of the dispersed phase by the PLA matrix and finer dispersed POE‐g‐GMA particles with narrow distribution. Moreover, the critical interparticle distance (Lc) of the dispersed domains for PLA/POE‐g‐GMA blends system at room temperature was also identified. POLYM. ENG. SCI., 2013. © 2012 Society of Plastics Engineers
Calcium binding and allosteric signaling mechanisms for the sarcoplasmic reticulum Ca2+ ATPase
Authors: Kekenes‐Huskey Peter M. , Metzger Vincent T. , Grant Barry J. , Andrew McCammon J. 
Published: July 2012

AbstractThe sarcoplasmic reticulum Ca2+ ATPase (SERCA) is a membrane‐bound pump that utilizes ATP to drive calcium ions from the myocyte cytosol against the higher calcium concentration in the sarcoplasmic reticulum. Conformational transitions associated with Ca2+‐binding are important to its catalytic function. We have identified collective motions that partition SERCA crystallographic structures into multiple catalytically‐distinct states using principal component analysis. Using Brownian dynamics simulations, we demonstrate the important contribution of surface‐exposed, polar residues in the diffusional encounter of Ca2+. Molecular dynamics simulations indicate the role of Glu309 gating in binding Ca2+, as well as subsequent changes in the dynamics of SERCA's cytosolic domains. Together these data provide structural and dynamical insights into a multistep process involving Ca2+ binding and catalytic transitions.
Comparative analysis of periprostatic implantation and intracavernosal injection of human adipose tissue‐derived stem cells for erectile function recovery in a rat model of cavernous nerve injury
Authors: You Dalsan , Jang Myoung Jin , Lee Jiyeon , Suh Nayoung , Jeong In Gab , Sohn Dong Wan , Kim Sae Woong , Ahn Tai Young , Kim Choung‐Soo 
Published: July 2012

AbstractBACKGROUNDWe compared periprostatic implantation (PPI) and intracavernosal injection (ICI) of human adipose tissue‐derived stem cell (ADSC) to facilitate recovery of erectile function in a rat model of cavernous nerve (CN) injury.METHODSBilateral CN dissection (BCND) was induced in Sprague–Dawley rats. After BCND 10 rats each were treated with PPI and/or ICI of ADSCs. After 4 weeks erectile responses to electric pelvic ganglion stimulation were studied. Each penis was evaluated in terms of the expression of neuronal nitric oxide synthase and smooth muscle content.RESULTSThe ratio of maximal intracavernosal pressure to mean arterial pressure was significantly decreased in the BCND group (24.5%) compared to the sham group (64.2%). PPI and ICI significantly improved erectile function (46.7% and 47.9%, respectively) compared to the BCND group. A combination of PPI and ICI (42.5%) did not afford any incremental effect on erectile function. After stem cell therapy, the expression of neuronal nitric oxide synthase increased slightly in the ICI group without statistical relevance, whereas the PPI and combination groups showed marginally significant increases (P = 0.08). In both the PPI and ICI groups, the smooth muscle content was similar to the sham group. The combination group showed remarkable increase in smooth muscle content to an extent greater than that seen when either treatment was given alone, although statistically not significant.CONCLUSIONPPI or ICI of ADSCs in a rat model of CN injury were equally effective in recovering penile erection, but may address different types of pathophysiology. Prostate 73: 278–286, 2013. © 2012 Wiley Periodicals, Inc.
Indigenous climate knowledges
Authors: Smith Heather A. , Sharp Karyn 
Published: July 2012

AbstractThis article describes, assesses, and explains the growing status of indigenous knowledges (IKs) in climate science and politics. Informed by a critical environmental perspective we review the literature on traditional ecological knowledge (TEK), explore the contested nature of this concept, and identify the numerous epistemological obstacles to the appropriate and respectful inclusion of traditional ecological knowledge. While we believe that TEK and Western science are complementary, the inclusion of TEK in climate science and politics has been uneven. In support of our argument, we present a framework for assessment of degrees of inclusion of TEK and apply the framework to the United Nations Framework Convention on Climate Change (UNFCCC), the Kyoto Protocol, the Intergovernmental Panel on Climate Change's Fourth Assessment Report (AR4), and the Arctic Climate Impact Assessment (ACIA). We find that the UNFCCC and the Kyoto Protocol do not account for either indigenous peoples or indigenous people's knowledges. The AR4 includes some references to indigenous peoples but they are often buried in regional chapters. The ACIA is the most inclusive of all the documents examined and represents an important starting point for the inclusion of IKs. Based on the findings of our assessment, we conclude with recommendations for moving forward with greater inclusion of IKs. WIREs Clim Change 2011 DOI: 10.1002/wcc.185This article is categorized under:

Social Status of Climate Change Knowledge > Sociology/Anthropology of Climate Knowledge
Overexpression of genes of the fatty acid biosynthetic pathway leads to accumulation of sterols in Saccharomyces cerevisiae
Authors: Shin Ga‐Hee , Veen Markus , Stahl Ulf , Lang Christine 
Published: July 2012

AbstractSaccharomyces cerevisiae strains with deregulated sterol and fatty acid biosynthesis pathways were analysed for sterol and fatty acid content and mRNA profiles, with the aim of identifying interactions between lipid biosynthesis pathways. Acetyl CoA carboxylase ACC1 and fatty acid synthases FAS1/FAS2 were overexpressed in wild‐type and squalene‐overproducing strains. ACC1 overexpression led to decreased fatty acid content in the squalene‐overproducing strain (factor of 0.7), while sterols and squalene were increased (factor of 1.5). In the wild‐type strain, ACC1 overexpression led to increased levels of both fatty acids and squalene/sterols (factors of 4.0 and 1.7, respectively). This parallel activation of the two pathways seems to be due to transcriptional co‐regulation of ACC1 and HMG1. While FAS1 and FAS2 overexpression had no effect in the wild‐type strain, FAS2 overexpression induced significant increase of sterols and squalene (factors of 7.2 and 1.3, respectively) and a concomitant decrease of both saturated and unsaturated fatty acids in the squalene‐overproducing strain (factor of 0.6). The microarray expression profiles showed that genes upregulated in ACC1‐overexpressing strains are FAS1, ERG11, ERG28, ERG5, ERG2 and ERG20, supporting the observed increase of zymosterol and saturated fatty acids. The high ACC1 expression level due to overexpression correlated with increased transcript levels of sphingolipid and sterol biosynthesis genes. The relationship between was shown using the Pathway Studio™ program. Copyright © 2012 John Wiley & Sons, Ltd.
Survival Benefit of Palliative Gastrectomy in Gastric Cancer Patients with Peritoneal Metastasis
Authors: Tokunaga Masanori , Terashima Masanori , Tanizawa Yutaka , Bando Etsuro , Kawamura Taiichi , Yasui Hirofumi , Boku Narikazu 
Published: July 2012

AbstractBackgroundThe survival benefit of palliative gastrectomy in patients with peritoneal metastasis as a single incurable factor remains unclear.MethodsA total of 148 gastric cancer patients with peritoneal metastasis underwent gastrectomy or chemotherapy at the Shizuoka Cancer Center between September 2002 and December 2008 and were included in this study. The effects of gastrectomy and chemotherapy on their long‐term outcome were investigated. Multivariate analysis was also performed to identify independent prognostic factors.ResultsGastrectomy was performed in 82 patients and subsequent chemotherapy was administered to 55. Chemotherapy was selected as an initial treatment for 66 patients. Median survival time (MST) was identical between patients with and without gastrectomy (13.1 vs. 12.0 months; P = 0.410). Conversely, MST was significantly longer in patients who received chemotherapy (13.7 months) than those who did not (7.1 months; P = 0.048). According to the results of multivariate analysis, chemotherapy (hazards ratio [HR] = 0.476; 95 % CI = 0.288–0.787) was selected as an independent prognostic factor, while gastrectomy was not.ConclusionsThe results of the present study did not show a survival benefit of palliative gastrectomy in selected patients with peritoneal metastasis. Instead, chemotherapy has to be considered as an initial treatment for these patients.
Evaluating Medical Marijuana Dispensary Policies: Spatial Methods for the Study of Environmentally‐Based Interventions
Authors: Freisthler Bridget , Kepple Nancy J. , Sims Revel , Martin Scott E. 
Published: July 2012

AbstractIn 1996, California was the first state to pass a Compassionate Use Act allowing for the legal use of marijuana for medical purposes. Here we review several current policy and land use environmental interventions designed to limit problems related to the influx of medical marijuana dispensaries across California cities. Then we discuss the special challenges, solutions, and techniques used for studying the effects of these place‐based policies. Finally, we present some of the advanced spatial analytic techniques that can be used to evaluate the effectiveness of environmental interventions, such as those related to reducing problems associated with the proliferation of medical marijuana dispensaries. Further, using data from a premise survey of all the dispensaries in Sacramento, this study will examine what characteristics and practices of these dispensaries are related to crime within varying distances from the dispensaries (e.g., 100, 250, 500, and 1,000 feet). We find that some security measures, such as security cameras and having a door man outside, implemented by medical marijuana dispensary owners might be effective at reducing crime within the immediate vicinity of the dispensaries.