bluuebunny/crossref_metadata_2025_split huggingface dataset:
Characterization of Amino Acid Mutations of Newcastle Disease Virus (NDV) In Swan Geese (Anser cygnoides) In East Java, Indonesia
Authors: Putri Naimah , Karni Ine 
Published: May 2024

Background: Newcastle disease (ND) is a highly contagious viral disease affecting the poultry industry. The NDV is classified into three strains based on their relative virulence, namely velogenic or highly virulent, mesogenic or moderately virulent, and lentogenic or lowly virulent. The clinical manifestations of the disease vary depending on many factors, such as host susceptibility and the virulence of the NDV strain. Objective: This study aims to analyze the amino acid mutations of the NDV in unvaccinated swan goose (Anser cygnoides) from various locations in Java. Methods: Samples were collected through cloacal swabs and isolated by inoculation in Specific Pathogen-Free (SPF) embryonated eggs that were nine days old. Hemagglutination and hemagglutination inhibition tests were conducted to confirm that the isolated virus was NDV. The isolated virus was processed using reverse transcription-polymerase chain reaction (RT-PCR) with primers that amplified partial sequences of the fusion (F) gene, which was analyzed to determine the pathotype. Results: The results indicated the presence of mutations in several regions. The amino acid changes occurred in 17 variable sites (7.2%) between RefSeq/JF950510 and ND/SW1/2018, 12 variable sites (5.1%) between RefSeq/JF950510 and ND/SW2/2018, 13 variable sites (5.5%) between RefSeq/JF950510 and ND/SW3/2018, and 19 variable sites (8.1%) between RefSeq/JF950510 and ND/SW4/2018. The amino acid sequences of the cleavage site of the fusion (F) protein revealed that all isolates had low virulence. Conclusion: The results indicated that mutations in the region outside the cleavage site not were incapable of altering the virulence of the virus.
Antimicrobial Resistance Profile of Foodborne Salmonella spp. and E. coli Isolates from Rodents and Shrews in Morogoro Municipality, Tanzania
Authors: Uwanyirigira Marie Chantal , Bapfakurera Elias Nelly , Mwega Elisa , Kimera Sharadhuli , Katakweba Abdul A.S. 
Published: May 2024

Background: Antimicrobial resistance (AMR) is a pressing global public health issue that affects both human and animal health. Small mammals, such as rodents and shrews, represent a significant reservoir of zoonotic infections. However, there is limited documented research specifically addressing Escherichia coli and Salmonella spp. resistant strains from small mammals. Purpose: This study was conducted to examin the occurrence of AMR E. coli and Salmonella spp. and their associated resistance genes in rodents and shrews. Methods: A total of 148 fecal samples from rodents and shrews were examined for E. coli and Salmonella spp. using culture methods and biochemical tests. Fifty isolates were subjected to antibiotic susceptibility testing using the disk diffusion method on Muller-Hinton agar. Genotypic analysis by PCR was used to confirm the bacterial strains and their resistance pattern genes. Results: Two bacteria were confirmed in 57 (38.5%) of the fecal samples. Specifically, E. coli and Salmonella spp. were identified in 54 (36.5%) and 3 (2%) fecal samples, respectively. Antimicrobial susceptibility testing revealed significant resistance in Rattus rattus. Molecular analysis confirmed that Salmonella spp. carry a larger proportion of resistance genes than E. coli. Specific resistance genes, including Sul1 and Sul2, were identified, constituting 15.4% of the total resistance genes. The prevalence of β-lactamase genes was remarkable, with a higher occurrence in Salmonella spp. Conclusion: In terms of human health, the implications of rodents and shrews serving as carriers and transmitters of various pathogens were highlighted. Given the possibility of unexpected zoonoses arising from the bacteria found in this study, these findings contribute to the understanding AMR in the context of bacterial infections in animals and humans.
Applications of Asymptotic Solutions of the Diffusivity Equation to Infinite Acting Pressure Transient Analysis
Authors: Wang Zhenzhen , Li Chen , King Michael J. 
Published: May 2024

Summary
Understanding how pressure propagates in a reservoir is fundamental to the interpretation of pressure and rate transient measurements at a well. Unconventional reservoirs provide unique technical challenges as the simple geometries and flow regimes [wellbore storage (WBS) and radial, linear, spherical, and boundary-dominated flow] applied in well test analysis are now replaced by nonideal flow patterns due to complex multistage fracture completions, nonplanar fractures, and the interaction of flow with the reservoir heterogeneity. In this paper, we introduce an asymptotic solution technique for the diffusivity equation applied to pressure transient analysis (PTA), in which the 3D depletion geometry is mapped to an equivalent 1D streamtube. This allows the potentially complex pressure depletion geometry within the reservoir to be treated as the primary unknown in an interpretation, compared with the usual method of interpretation in which the depletion geometry is assumed and parameters of the formation and well are the unknown properties. The construction is based upon the solution to the Eikonal equation, derived from the diffusivity equation in heterogeneous reservoirs. We develop a Green’s function that provides analytic solutions to the pressure transient equations for which the geometry of the flow pattern is abstracted from the transient solution. The analytic formulation provides an explicit solution for many well test pressure transient characteristics such as the well test semi-log pressure derivative (WTD), the depth of investigation (DOI), and the stabilized zone (SZ) (or dynamic drainage area), with new definitions for the limit of detectability (LOD), the transient drainage volume, and the pseudosteady-state (PSS) limit. Generalizations of the Green’s function approach to bounded reservoirs are possible (Wang et al. 2017) but are beyond the scope of the current study. We validate our approach against well-known PTA solutions solved using the Laplace transform, including pressure transients with WBS and skin. Our study concludes with a discussion of applications to unconventional reservoir performance analysis for which reference solutions do not otherwise exist.
Preparation and Performance of High-Temperature-Resistant, Degradable Inorganic Gel for Steam Applications
Authors: Chen Lifeng , Zhang Zhaonian , Zeng Huiyong , Huang Feiyang , Lu Xuanfeng , Sheng Weiwei 
Published: May 2024

Summary
To address the problems of steam channeling caused by the nonhomogeneity and fluid compatibility of the reservoir in heavy oil reservoirs and the permanent damage to the reservoir easily caused by traditional plugging agents, this study adopted polyaluminum chloride (PAC) as the main agent, urea as the coagulant promoter, and thiourea as the stabilizer and prepared a high-temperature-resistant (up to 350°C) degradable inorganic aluminum gel with excellent performance. Initially, scanning electron microscope (SEM) tests were conducted on gels with and without urea. Energy-dispersive X-ray spectroscopy (EDS)-mapping analysis of gels immersed in water with different mineralization levels for 5 days was then performed. The results revealed that the addition of urea led to a tighter and more complete crosslinked structure, significantly enhancing the mechanical strength of the gel. As water mineral content increased, the gel’s microstructure became denser and smoother. Metal cations on the cross-sectional surface increased gradually and distributed uniformly, further confirming the mechanism of the synergistic salt effect of soluble strong electrolytes and urea in strengthening the gel. Finally, the plugging and degradable properties of the gel were evaluated, and the results showed that the plugging percentage of the gel could still reach 97.6% after aging at 350°C for 30 days, and the gel had excellent plugging and diversion in dual sandpack experiments where the permeability ratio was less than 44. At 250°C, the degradation percentage of the gel was more than 98% at 5 days under the nonacid degradation system and 94% at 5 days under the acid degradation system. The gel showed good degradability and effectively reduced the damage to the reservoir.
Social Capital and Sustained Viral Suppression Among People Living with HIV/AIDS (PLHIV) Initiated on Anti-Retroviral Therapy in South-Eastern, Nigeria
Authors: Obokon Gabriel Omen , Oparaocha Evangeline Tochi , Chukwuocha Uchechukwu Madukaku , Ekeleme Uzochukwu Godswill , Dozie Ugonma Winnie. , Chukwu Rita Ogechi , Enejoh Victor , Eteike Precious Okechukwu , Uka-Kalu Ezinne Chioma 
Published: May 2024

Abstract

The global health challenge posed by the human immunodeficiency virus (HIV) persists. Although significant strides have been made in enhancing the quality of life for individuals with HIV through expanded access to anti-retroviral therapy, the attainment of continuous viral suppression remains a multifaceted challenge. Consequently, this research explored the relationship between social capital and viral suppression in individuals undergoing anti-retroviral therapy for HIV infection. We conducted hospital-based unmatched Case-control study among 1,202 PLHIV, aged ≥ 10yrs on ART. The Word Banks social capital integrated questionnaire–SC–IQ) was adapted and used to measure social capital among study participants, their viral-load records were extracted from hospital-based electronic-medical-records. Data were entered into SPSS Version-26 software and analysed using descriptive statistics and inferential statistics using logistic regression at < 0.05 statistical significance. Majority were females 748 (62.2%), 365 (30.4%) were aged 25–34 years, the smallest age group was ≥ 55yrs 131 (10.9%) and mean age was 17.7yrs (St. dev = 12.2 years). A 35.8%, 21.3% and 42.9% level of low, moderate and high social capital respectively was discovered among participants. High social capital was recorded among virally suppressed patients (cases)-81.8%, while low social capital was majorly seen among virally non-suppressed (controls)–80.9%. Low and high social capital were significantly associated with viral suppression among PLHIV on ART at (P < 0.0001). Revealing that Patients with high social capital were 2.88 times more likely to achieve sustained viral suppression as compared to those with low social capital (AOR = 2.88, 95% CI = 1.68–4.93). Social capital was discovered to be positively associated with viral suppression. Therefore, promoting strong social capital can enhance sustained viral suppression among PLHIV on ART, which is the ultimate goal of HIV care and treatment interventions, as well as pivotal in achieving HIV epidemic control efforts.
Evaluating the Safety and Efficacy of Cinobufacini in Patients with Oral Potentially Malignant Disorders: An Open-Label Pilot Study
Authors: Liu Yang , Huang Ping , Wang Yuhong , Wang Yuanyuan , Wei Minghui , Cui Yuan , Wei Jiao , Wang Xinwen 
Published: May 2024

Abstract

Objective
Herein, we collected preliminary data on the effects of cinobufacini, a Chinese medicine extracted from Venenum Bufonis, to assess its safety and efficacy in patients with potentially malignant disorders (OPMDs).
Methods
Patients with histologically confirmed OPMDs were enrolled in this open-label uncontrolled pilot clinical study for a four-week treatment. The main outcome measures were efficacy (lesion size, activity score, and numerical rating scale) and safety (blood cell count, general biochemistry, liver and adrenal function tests, and adverse effects).
Results
A fifteen-patient cohort (9 females and 6 males; average age, 53.67 ± 11.69 years) with various OPMD types successfully completed the four-week cinobufacini treatment. Among them, only two patient (13.33%) exhibited partial clinical response (lesion size reduction, ≥ 50%). It was observed that the lesion size decreased in 10 participants (66.67%), the mean area score showed a significant reduction from 6.53 ± 2.16 to 4.50 ± 1.60 (P < 0.05). When assessed using the activity scoring system, 9 participants (73.33%) demonstrated a decrease in their activity score, with a significant decrease in mean activity score from 5.40 ± 1.48 to 3.13 ± 0.68 (P < 0.05). The mean numerical rating scale (NRS) score showed a significant reduction from 3.23 ± 1.73 to 1.73 ± 0.92 (P < 0.05). Remarkably, four patients had a histopathological complete response after extending treatment to 12 weeks. Overall, most patients had no adverse effects except four cases reporting mild gastrointestinal discomfort.
Conclusions
The findings from this open-label pilot study highlight the potential of cinobufacini as a promising therapy for OPMDs, underscoring the need for larger and longer-term trials.
The trial registration number (TRN): IRB-YJ-2022005；The date of registration:01/06/2022
Optimality Results for Non-Differentiable Multiobjective Fractional Programming Problems under E-B-Invexity
Authors: Mishra S. K. , Singh Dhruv , Kumar Pankaj , Singh Vandana 
Published: May 2024

Abstract

In this paper, we deal with non-convex multiobjective fractional programming problems involving E-differentiable functions (MFPE). The so-called E-Karush-Kuhn-Tucker sufficient E-optimality conditions are established for non-smooth vector optimization problems under E-B-invexity hypothesis. To illustrate the established results, we present an example in which the involved functions are E-B-invex.
MSC Classification: 90C32, 90C46, 49J52, 90C30, 90C29
Acquired Hemophilia Successfully Treated with Recombinant Factor Ⅶa: A Case Report
Authors: Mahmoudiandehkordi Shaghayegh , Hadipour Pedram 
Published: May 2024

Abstract

Acquired Hemophilia A (AHA) is a disorder characterized by the impaired clotting ability of the blood, primarily resulting from a deficiency in factor VIII, a crucial clotting protein. It is an infrequent disorder that affects a minority of individuals. This condition can pose a life-threatening risk, with reported mortality rates reaching as high as 22%. The diagnosis of AHA is challenging owing to its non-specific presentation and low prevalence rate. The primary objectives of treatment for AHA encompass the cessation and prevention of bleeding episodes, eradication of the inhibitor, and management of the underlying disease in secondary cases. This case report summarizes the successful treatment of a patient with AHA and major bleeding with the repeated use of prednisolone, recombinant factor VIIa, and rituximab.
Suspected illegal abortion and the use of misoprostol leading to the silent uterine rupture: A case report
Authors: Mahmoudiandehkordi Shaghayegh , Hadipour Pedram 
Published: May 2024

Abstract

Uterine rupture is an uncommon, serious, and potentially life-threatening complication characterized as a disruption of the whole uterine muscle and the visceral peritoneum. Herein, we report a case of silent uterine rupture following illegal abortion via misoprostol administration. A 28-year-old female Gravida 2 Parity 1 living 1 at 18 weeks of gestation with a history of previous cesarean section presented to the hospital. She took 1000 µg of misoprostol tablet 1 day prior to her admission and due to unsuccessful abortion, presented to the hospital. The evidence of uterine perforation was not identified in the ultrasonography investigation. Following several attempts for abortion using misoprostol, oxytocin, trans-cervical Foley catheter, and dilation and evacuation (D & E) procedure, patients underwent exploratory laparotomy. Uterine rupture was diagnosed during surgery. The uterus was torn, and the fetus and placenta were found in the abdominal cavity with omentum sealing the rupture of the uterus. The fetus and placenta were removed and after proper toileting and controlling of bleeding, the uterus was closed. This case highlights the need for high-quality obstetric care and skilled paramedical and medical staff. It warns that medications such as prostaglandins and oxytocin should be administered only by experts and, lastly, that health facilities should not manage deliveries if they are not equipped well for the complications of delivery and labor. Our case also highlighted the possibility of silent uterine rupture in which the diagnosis is even harder. As a result, in cases where abortion approaches are unsuccessful, health practitioners should think about the possibility of uterine rupture.
Tracking ChatGPT Research Insights From Scientometric Analysis
Authors: wagay Javaid 
Published: May 2024

Abstract

Little is known about the scientific literature regarding the new revolutionary tool, ChatGPT. We aim to perform a Scientometric analysis to identify ChatGPT-related publications A comprehensive study delving into the realm of ChatGPT has been undertaken, utilizing a robust methodology. Leveraging web of science, 1298 documents were meticulously analyzed through scientometrics, shedding light on publishing trends, productive countries, and keyword dynamics. The year 2023 witnessed a surge in scientific productivity centered around ChatGPT, with a substantial corpus of 1298 documents contributing to the discourse. The average citations per document, standing at approximately 9.298, underscore the significant engagement and interest within the academic community. collaborative nature of research on ChatGPT is evident from the involvement of 3938 authors, with an average of 3.73 co-authors per document. This indicates a significant level of collaboration within the scholarly community, fostering interdisciplinary exchange and knowledge sharing. Annals of Biomedical Engineering" stands out with a significant h-index of 150 and an impact factor of 3.8. With 250 total citations and 42 publications, this journal, published by Springer Netherlands, has been instrumental in advancing knowledge at the intersection of biomedical engineering and artificial intelligence, including the application of ChatGPT in healthcare contexts.Another prominent source is "Nature," renowned for its high impact factor of 69.5 and impressive h-index of 1331. The United States leads the pack with 310 articles, indicating a significant contribution to research on ChatGPT. China closely follows with 250 articles, demonstrating the growing presence and investment in AI-related research within the country.India emerges as a notable contributor with 156 articles, showcasing its increasing involvement in advancing knowledge and understanding of ChatGPT.
Opportunities for energy-free groundwater extraction through artificial autoflow well: a conceptual feasibility in Indian context
Authors: Dwivedi S N , Chowdhuri Sujatro Ray , Singh Madhukar 
Published: May 2024

Abstract

Prospects for converting a water well tapping confined aquifer into an artificial autoflow well exists in several areas. However, the energy advantage offered by a confined aquifer is generally ignored and even in areas where the piezometric head in the well rests at very shallow depth from the ground surface, pumps are lowered for extracting groundwater. In this paper, we present a conceptual feasibility of converting wells constructed in confined aquifers into an artificial autoflow well. There exists a promising prospect of creating an artificial autoflow condition which can lower the dependence on energy for groundwater extraction. Such wells are feasible in areas with multi-aquifer set-up where a thick layer of surficial clay overlies the main aquifers making the area unsuitable for dugwells; areas where the water level in the top unconfined aquifer (phreatic aquifer) has declined below 20 m from ground level resulting in drying up of dugwells and shallow handpumps and; areas where the shallow aquifer is contaminated and not suitable for drinking and domestic uses and the deeper confined aquifers are contamination free. A suitable design for an artificial autoflow well is proposed in the paper which can provide an energy free alternative for groundwater extraction for meeting the requirement of small and marginal farmers as well as for meeting the drinking and domestic requirements of rural households in areas where the shallow aquifer system is either contaminated or desaturated.
Evaluation of oropharyngeal structure and DISE findings for successful soft palatal webbing flap pharyngoplasty in obstructive sleep apnea
Authors: Han Seung Cheol , Kim Minju , Kim Hyun Jung , Oh Jayoung , Han Doo Hee , Won Tae-Bin , Kim Dong-Young , Rhee Chae-Seo , Kim Hyun Jik 
Published: May 2024

Abstract

Soft palate webbing flap palatopharyngoplasty (SPWFPP) has been introduced to enhance the stability of the lateral pharyngeal wall with minimal post-operative complications by eliminating the need for tonsillectomy in obstructive sleep apnea (OSA) patients. We analyzed the anatomic findings of oropharynx for determination of outcome in OSA patients requiring SPWFPP. Twenty-eight OSA patients who underwent SPWFPP combined with septoturbinoplasty were included in this study. Patient medical records, including endoscopic findings, polysomnography (PSG) data, and drug-induced sleep endoscopy (DISE), were analyzed. PSG data revealed that SPWFPP provided significant improvements of AHI score in severe OSA patients with lateral pharyngeal wall collapse, whereas AHI scores of mild and moderate OSA cases minimally declined following SPWFPP. Notably, some experienced abrupt increase in AHI level after surgery particularly in mild OSA cases, and those patients showed collapse of the epiglottis before surgery according to DISE findings. The outcome of SPWFPP was successful in severe OSA patients whose epiglottis was not collapsible on preoperative DISE findings and in patients with palatal collapse of grade III or higher. Therefore, a close analysis of DISE findings before SPWFPP reveals important indicators for predicting better surgical results and selecting OSA patients suitable for SPWFPP.
Uncertain interrupted time series analysis
Authors: Li Xiuheng , Sheng Yuhong 
Published: May 2024

Abstract

The uncertain time series (UTS) is a sequence of uncertain observations in chronological order. The uncertain autoregressive (UAR) model is one of the basic UTS models believes the uncertain time series value relies mainly on it's historical values linearly. This paper proposes uncertain interrupted time series (UITS) models aiming at analysing time series datas with large-scale interventions on the base of uncertain autoregressive model. The UITS model can reflect the effect of an intervention and makes prediction about the future in the presence of intervention. Three types of uncertain interrupted time series models are introduced in this paper. In addition, residual analysis and prediction intervals are also proposed. Finally, some numerical examples are given.