bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Efficacy of a Combination Administration of Gonadotropin‐Releasing Hormone Agonist and Gonadotropins for Controlled Ovarian Hyperstimulation in IVF Program
Authors: Chang Yoon Seok , Kim Seok Hyun , Shin Chang Jae , Kim Jung Gu , Moon Shin Yong , Lee Jin Yong 
Published: August 2010

AbstractIn 105 patients with the past history of poor response to the previous controlled ovarian hyperstimulation (COH) due to poor follicular growth or premature LH surge, the efficacy of pituitary suppression with gonadotropin‐releasing hormone agonist (GnRHa) in IVF/GIFT program was evaluated in 112 cycles of COH using a combination regimen of leuprolide acetate (Lupron) and FSH/hMG or pure FSH from May to December, 1989. After suppression phase, serum E2 and progesterone levels decreased significantly, but there was no change in serum LH and FSH levels. There was no occurrence of premature LH surge during COH. Eleven cycles (9.8%) were cancelled, and 3 cycles (3.0%) failed in the transvaginal oocytes retrieval. The 7.00±3.32 follicles (FD ≥ 12 mm) were observed, and 6.11±4.15 oocytes were retrieved. The 3.59±2.57 oocytes were fertilized and cleaved with the cleavage rate of 55.7%. In 83 IVF patients, 4.08±2.39 embryos were transferred, and 16 pregnancies were obtained with the pregnancy rate per ET of 19.3%. In 6 GIFT patients, 7.83±3.31 oocytes were available for transfer. When compared with the previous 108 cycles, the cancellation rate during COH was decreased and all the parameters of the outcome of COH including the pregnancy rate were increased. These data suggest that GnRHa therapy for pituitary suppression is an effective adjunct to the current gonadotropin regimens for COH in IVF/GIFT and can increase the probability of oocytes retrieval and pregnancy, especially in the previous poor responders.
Mature Cystic Teratoma of the Uterine Cervix
Authors: Iwanaga Shigeaki , Ishii Hiroki , Nagano Hidetsugu , Shimizu Masahiko , Nishida Takashi , Yakushiji Michiaki 
Published: August 2010

AbstractA rare case of extragonadal teratoma which occurred primarily in the uterus is described. The tumor developed in the uterine cervix to form a polypoid appearance, and consisted of ectodermal, mesodermal and endodermal derivatives. This is the 14th such tumor to be recorded in world literature. A review of the literature and its possible histogenesis are briefly described.
Genital Human Papillomavirus Infection among Women from Major Ethnic Groups in Singapore
Authors: Chow Vincent T. K. , Tham K. M. , Lim‐Tan S. K. , Sng Ivy T. Y. , Bernard H. U. 
Published: August 2010

AbstractThe close epidemiological relationships between specific genital human papillomavirus (HPV) types and neoplasia of the cervix uteri have been extensively documented worldwide, including Singapore. Cervical cancer incidence rates in Singapore show variations between the major ethnic groups. To ascertain the corresponding HPV infection rates among the various races in Singapore, we analysed the cervical smears of 225 women by filter in situ DNA hybridization, and compared the data with a previous similar study. Fourteen (6.2%) individuals were HPV‐positive, with HPV 16 and HPV 31 being the commonest types. No significant difference between HPV positivity rates in Chinese (5.0%) and in Malays (6.7%) was found, even though Chinese have a higher cervical cancer incidence than Malays. Furthermore, the cervical HPV carriage rate among women with normal cytology was 5.9%. In the light of reports of high genital HPV prevalence rates detected by DNA amplification, these data support the notion that HPV infection is commonly latent and requires the cooperation of other factors for cervical carcinogenesis.
Uterine Activity in Dysfunctional Labour and Target Uterine Activity to Be Aimed with Oxytocin Titration*
Authors: Arulkumaran S. , Chua S. , Chua T. M. , Yang T.M. , Piara S. , Ratnam S. S. 
Published: August 2010

AbstractUterine activity was quantified using a transducer tipped intrauterine catheter in 75 nulliparous women with dysfunctional labour. The active contraction area profiles in these women were below the median levels reported for those who had normal progress of labour from our institution. When uterine activity was augmented with oxytocin, 90.7% progressed in labour and delivered vaginally. Six patients (8%) showed poor progress despite good uterine activity and had to be delivered by caesarean section (CS) for failure to progress and signs of cephalopelvic disproportion. The pre‐ and post‐augmentation uterine activity were similar in those who delivered vaginally or by CS and was not helpful in identifying those who had cephalopelvic disproportion. Of the 75 women who had slow progress of labour, 50 had a contraction frequency of less than 1 in 3 min whilst 25 had a minimum frequency of 1 in 3 min or more. All except one in the latter group delivered vaginally when oxytocin was titrated to achieve a contraction frequency of 1 in 2 to 2 1/2 min which were clinically judged to be adequate based on a duration >40 sec. Oxytocin should be titrated to achieve a target contraction frequency of 1 in 2 to 2 1/2 min lasting >40 sec to achieve good obstetric outcome in those with dysfunctional labour.
Prenatal Diagnosis of Rubella Infection by Fetal Blood Sampling
Authors: Suzumori Kaoru , Iida Tadashi , Adachi Ritsuko , Okada Setsuo , Yagami Yoshiaki 
Published: August 2010

AbstractPrenatal diagnosis of rubella infection was attempted at 21 to 23 weeks of gestation by measuring rubella‐specific IgM by ELISA in blood obtained from 16 fetuses whose mothers had been confirmed rubella infection during pregnancy. Specific IgM was detected in 9 fetuses. In 1 case, the time of the appearance of the rash was 20 weeks of gestation and this pregnancy went to term resulting in a healthy baby without clinical evidence of congenital rubella. The remaining 8 patients had their pregnancies terminated, and fetal infection was confirmed by blood tests after the abortion. No specific IgM was detected in the 7 other fetuses. However, in 2 IgM fetal blood negative cases whose mothers had had the rash at 17 and 20 weeks of gestation, the neonates showed positive IgM findings, but were apparently healthy. The reasons for the false‐negative findings are discussed.
Low Birth Weight in Kuala Lumpur
Authors: Tahir Hashim M. , Ismail Nik N. , Gebbie Donald A. M. 
Published: August 2010

AbstractLow birth weight babies are defined as those weighing under 2,500 g. They make 13.5% of all births at the Maternity Hospital, Kuala Lumpur but contribute to 74.8% of all deaths. They are most likely to be Indian babies and least likely to be Chinese. Among all 3 communities, the primigravidae tend to produce smaller babies than multiparae but this is also true for the Indian of parity more than 3. The Malay teenager is more likely to produce small babies than their older counterparts but not so with the Indian and Chinese. There are definite clinical factors associated with or causing the births of small babies and the lighter the baby, the more influential are these factors. Maternal hypertension, antepartum haemorrhage, multiple pregnancy and unexplained intrauterine death are the 4 outstanding associations with both low birth weight and perinatal death. Although the spontaneous (often premature) onset of labour was the commonest preceding factor, it was much less important in the lowest birth weight groups of babies and was a less important contributor to perinatal death.
Effect of Estrogen and Progesterone on the Growth of Human Ovarian Dysgerminoma Heterotransplanted to Athymic Nude Mice
Authors: Ochiai Kazunori , Isonishi Seiji , Hirama Yoshiaki , Yasuda Makoto , Terashima Yoshiteru 
Published: August 2010

AbstractThe effects of estrogen and progesterone on the growth of dysgerminoma of ovary heterotransplanted to ovariectomized athymic nude mice (OVX‐NUs) were examined. OVX‐NUs were divided into 6 groups and a subcutaneous injection of either 1 μg or 10 μg of estradiol (E1 or E10), 0.1 mg or 1 mg of progesterone (P0.1 or P1), or a combination treatment of E1 and P1 (E1+P1), or sesame oil as a vehicle control (oil) was given every other day for 2 weeks. Tumor size was recorded every day and the volume doubling time (VDT) was calculated. Tumor bearing OVX‐NUs were killed on day 21 and tumor tissue was excised for retransplantation, histological examination and cytosol receptor assay.E10 treatment accelerated tumor growth and shortened VDT to 25 hours compared to 44 hours for the control group. P1 treatment delayed the tumor growth (VDT: 71 hrs) and E1+P1 treatment further inhibited it (VDT: 197 hrs). E1 or P0.1 did not have any effect on the tumor growth.The levels of both the estrogen receptor (ER) and progesterone receptor (PR) of the original tumor were 5 fmol/mg protein, respectively. Hormone treatment had no remarkable effect, except for a significant increase in PR after estrogen treatment and this result seems to be responsible for the enhanced inhibitory effect of E+P on tumor growth. These effects were also observed histologically.In conclusion, the dysgerminoma used in this study was sex steroid hormone dependent and P alone or in combination with E could be a choice for the treatment of such ovarian dysgerminoma.
Cervical Adenocarcinoma Metastasizing to the Skin Incision: A Case Report
Authors: Dhall Rajiv , Grant Kenneth A. 
Published: August 2010

AbstractIn a patient previously operated upon for cervical adenocarcinoma, an abdominal wall swelling of identical histology developed in the surgical incision line. The skin involved was the site of external irradiation. The case is discussed and the literature reviewed.
Prevention by Urinastatin ofCis‐Diamminedichloroplatinum‐Induced Nephrotoxicity in Rabbits: Comparison of Urinary Enzyme Excretions and Morphological Alterations by Electron Microscopy
Authors: Kobayashi Hiroshi , Ohi Hidekazu , Terao Toshihiko 
Published: August 2010

AbstractAcute nephrotoxicity was produced by 3 mg/kg intramuscular administrations ofcis‐diamminedichloroplatinum (CDDP) in rabbits. Urinary enzyme excretions of arylamidase and γ‐glutamyl transpeptidase, and morphological alterations by electron microscopy were used as endopoints to quantitate the severity of nephrotoxicity. The preventive effect of urinastatin (US), a trypsin inhibitor, on CDDP‐induced nephrotoxicity was evaluated. The alteration of urinary enzyme excretions did not parallel the severity of renal morphological changes. In proximal tubular cells, the morphological alterations consisting of nuclear irregularity, brush border disruption, and lysosomal membrane destruction were observed. In contrast, in rabbits treated concurrently with CDDP and 10,000 unit/kg of US, CDDP‐induced morphological changes observed in rabbits without US were completely absent. The differences in urinary enzyme excretions and morphological alterations between US‐treated rabbits and the US‐nontreated group were enough to fully account for the drastic protective effect of US against CDDP nephrotoxicity.
Grandmultiparity in Malaysian Women
Authors: Tai Christina , Urquhart Rennie 
Published: August 2010

AbstractGrandmultiparity is an ill defined term, but it is generally believed that increasing parity after the fifth delivery increases the risks of child bearing for both the mother and fetus. Four hundred seventy‐seven women aged less than 35 years of parity 5 and above who delivered during one year period at the University Hospital, Kuala Lumpur were studied. There were 406 women of parity 5 and 6 and 71 women of parity 7 and above. The 2 groups as a whole comprised 7.5% of the obstetric population for that year. Obstetric performance in the 2 groups of grandmultipara was compared with 1,135 women, aged 25 to 34 years, having their second baby during the same period. Women of parity 7 and above were significantly more likely to be from lower socioeconomic groups, and suffer from anaemia, hypertension and preeclampsia. They were also significantly at risk of preterm delivery and delivering infants weighing less than 2.5 kg. In addition, the perinatal mortality rate was significantly greater in the highly parous group (Para >7) than in women of parity 5 and 6 or the control group. Apart from a significant increase in the incidence of anaemia, women of parity 5 and 6 had a similar obstetric performance and perinatal outcome to that of the control group. We conclude that grandmultiparity per se is not an obstetric risk factor until after the seventh delivery. These findings have implications for those who plan the provision of obstetric services for the community.
Bilateral Ovarian Cysts in a Newborn: A Case Report
Authors: Lira C. T. , Wong K. K. , Yap Y. F. , Sivanesaratnam V. 
Published: August 2010

AbstractLarge ovarian cysts in the fetus are uncommon. Ultrasonography has helped in the detection of these cysts antenatally and in the newborn female infant. A case of bilateral ovarian cysts in a newborn is presented. The choice of management between conservative measures and surgical approaches remains controversial.
A Study on the Placental Transport Mechanism of Vitamin K2 (MK‐4)
Authors: Iioka Hideaki , Akada Shinobu , Hisanaga Hiroyasu , Shimamoto Takako , Yamada Yoshihiko , Moriyama Ikuko S. , Ichijo Motohiko 
Published: August 2010

AbstractThe present study was primarily concerned with in vitro investigation of vitamin K2 (MK‐4) transport using human placental villous tissues, with the objective of elucidating the placental transport mechanism of vitamin K2.

When vitamin K2 (MK‐4) was not administered to gravidae, the observed concentrations of vitamin K2 were 0.32±0.07 ng/ml in the maternal venous blood, undetectable in umbilical venous blood, and 1.01 ±0.37 ng/g wet tissue in the placental villous tissue.
When vitamin K2 was administered to gravidae, (20 mg/day X 7 days per os), the corresponding concentrations were 0.89±0.21 ng/ml in the maternal venous blood, 0.18±0.06 ng/ml in umbilical venous blood, and 5.38± 1.05 ng/g wet tissue in the placental villous tissue.
In vitro studies using placental villous tissue indicated that vitamin K2 transport into villous tissue is not active, but suggested the existence of a highly vitamin K2 specific transport system in the human placenta. On the other hand, the results of comparison studies of transport of vitamin K2 and vitamin K1 into villous tissue indicated that transport activity with respect to the former vitamin was higher. Moreover, comparison of vitamin K2 transport into villous tissue at the end of the first trimester and at full term revealed that transport was somewhat higher during the final stage.

In summary, the above results indicated that whereas transport of vitamin K1 into the fetus is not especially pronounced, transport into the placental villous tissue is comparatively good.
Sonographic Evaluation of Clinical Suspicion for Ectopic Pregnancy
Authors: Tongsong Theera , Wanapirak Chanane , Siriwattanapa Pannee , Pongsuthirak Pallop 
Published: August 2010

AbstractsAnalysis of transabdominal ultrasonic findings of 167 patients presented with clinical suspicion of extrauterine pregnancies (EUP), all with measurable serum HCG, has been undertaken. Patients were divided into two main groups, namely those with demonstrable typical intrauterine gestational sac (46.7%), and those without (53.3%). This later group of patients, i.e., without intrauterine sac, was further subdivided into four other groups depending on whether or not they have adnexal mass and/or fluid in cul‐de‐sac. In this first subgroup of patients (21 cases), without any demonstrable mass or fluid, a positive predictive value (PPV) for EUP of only 28.6% was obtained. With ultrasound showing fluid but no mass, the PPV was 55.6%, while those with both mass and fluid, the PPV as high as 95.7% was possible.Characterization of the adnexal mass or cul‐de‐sac findings among those with empty uterus may further improve PPV.The results of this study indicates that ultrasonic examination can help to provide a more correct diagnosis in the investigation of EUP. EUP can be easily excluded, in the great majority of cases, with sonographic visualization of intrauterine pregnancy. In the case of empty uterus with no mass nor fluid, patients should be closely followed up with HCG titer and ultrasonic examination. For those with empty uterus with fluid, culdocentesis may be indicated; whereas in the case of empty uterus with mass, laparoscopy should be considered as additional investigative procedures.
Analysis of Urinary Protein by Immunoblot Method Using Unconcentrated Urine in Preeclampsia
Authors: Yamamoto Tatsuo , Yoshimura Sachiko , Sasamori Yukifumi , Sakamoto Takako , Ogino Masahiro , Kambegawa Akira , Okinaga Shouichi , Arai Kiyoshi 
Published: August 2010

AbstractIn order to investigate the renal change in preeclampsia, molecular weight and specific protein analyses in unconcentrated urine were performed by the immunoblot method. Urine samples were taken from 34 preeclamptic cases (pure type), including 20 severe cases. Polypeptide profiles of urine consisted of four patterns: low MW (L) pattern (tubular damage), high MW (H) pattern (glomerular damage), high and low MW (HL) pattern, and middle MW (M) pattern. The incidences of the HL, H, L, and M patterns were 26.5%, 14.7%, 11.8%, and 47.1%, respectively. The HL pattern was found more frequently in severe proteinuria than in mild proteinuria. High incidences of the HL and H patterns were found in the hypertensive group. Larger amounts of IgM, fibronection, IgG, and β2 microglobulin in urine were confirmed using specific antibodies. Our results suggest that the immunoblot method makes it possible to differentiate glomerular and tubular damages and to evaluate the severity of renal damage in preeclampsia using unconcentrated urine.
Bone Metastasis in Ovarian Cancer
Authors: Kumar Lalit , Bhargava V. L. , Rao R. C. Keshav , Rath G. K. , Kataria S. P. 
Published: August 2010

AbstractBone involvement in carcinoma of ovary occurs rarely. In a review of 103 patients over last 3 years we have seen 4 such patients (serous‐2, mucinous‐1, mixed germ cell tumour‐1). Patients presented with severe localized bone pain, bony swelling and difficulty in walking. The common sites of involvement were vertebrae, pelvic bones and skull. Radiologically the osteolytic lesions were commonest. Bone lesions were associated with abdomino‐pelvic disease in 3 patients. Cisplatinum based chemotherapy in addition to local radiation resulted in significant response in 2 patients; one complete and one partial response. The median survival was 7.5 months (range 6–39 months) after bone metastasis. We conclude bone involvement in cancer ovary is associated with poor prognosis.
Effect of Menstruation on Serum CA125 Levels
Authors: Kan Yuen‐Yee , Yeh Shin‐Hwa , Ng Heung‐Tat , Lou Ching‐Mee 
Published: August 2010

AbstractCA125 levels were measured in the sera of 54 women with normal menstrual cycle and without infectious, benign and malignant gynecologic disorders. In 54 subjects studied, 13 (24%) had no significant variations in serum CA125 levels throughout the menstrual cycle. In contrast, there 41 (76%) had significant variations in serum CA125 with peak levels (51.8±6.5 U/ml, mean±SEM) during menstruation. The concentration reached a normal value (17.7±1.6 U/ml, mean±SEM) at proliferative phase, and remained low throughout the rest phases of the cycle. The mean peak level was significantly higher than that at proliferative phase (P<0.001), where as no significant difference in mean concentration was detected between sequential phases from proliferative phase to premenstrual phase (P>0.1). Among 41 with variable CA125 levels in the menstrual cycle, more than half of them, namely 39% of the total (21/54), had the levels of the upper limit or normal values.
A Case Report: Cervical Pregnancy with Placenta Percreta an Ultrasonic Assisted Diagnosis
Authors: Monks Peter L. , Catalano Salvatore , Close Peter J. 
Published: August 2010

AbstractA rare cervical pregnancy is reported, discussing the difficulty differentiating this condition from the cervical phase of an incomplete abortion. Placenta percreta further complicates this case.Ultrasound will give a firm diagnosis of cervical pregnancy and associated placenta percreta.Conservative and radical surgical care determined by vital signs are discussed.
Estradiol Administered in a Percutaneous Gel for the Prevention of Postmenopausal Bone Loss
Authors: Ng Heung‐Tat , Chang Sheng‐Ping , Yang Tzay‐Shing , Cho Min‐Ping , Wei Tzann‐Chyang 
Published: August 2010

AbstractSixty‐one postmenopausal women were randomized into 3 groups. Two groups of women were treated with estrogen replacement therapy (ERT) by percutaneous administration of estradiol gel at a dosage of 1.25 g and 2.5 g, respectively. The third group of women, receiving no treatment except placebo, was studied concurrently as a control group. Bone mineral density (BMD) was measured by quantitative computed tomography (QCT) in the vertebrae from T12‐L3 and hormones (E1, E2, FSH, LH and testosterone) were determined by radioimmunoassay at baseline, then at 6 monthly intervals thereafter. One year of the study has been completed thus far.The results of this study indicate that: (1) loss of BMD in the control group was observed significantly only in surgical menopausal women and no significant loss of BMD was observed in women receiving ERT treatment regimens; (2) decrease of E1 in control group and increase of E1 in the treatment group were both significant.These data suggest that percutaneous ERT may be used in prevention of postmenopausal bone loss, particularly in surgical menopausal women and the increased E1 may play a beneficial role in inhibiting loss of bone mass and relieving menopausal syndrome. Different dosages of estradiol gel which did not create any significant difference between the 2 treatment groups, need a longer period of follow‐up.
Cisplatin, Vinblastine and Bleomycin in Advanced and Relapsed Germ Cell Tumours of Ovary
Authors: Kumar Lalit , Bhargawa V. L. , Kumar Sunesh 
Published: August 2010

AbstractSeventeen patients with germ cell tumours of ovary were treated with 4 cycles of cisplatin, bleomycin and vinblastine (PVB) chemotherapy (CT). All patients had undergone prior surgery: hysterectomy + bilateral salpingoophorectomy + omentec‐tomy—5, salpingoophorectomy + debulking surgery—10 and biopsy alone in 2 patients. Four of seventeen patients had relapsed earlier and received PVB as second line therapy. FIGO staging revealed: stage IIB in one, III C in 12 and stage IV in 4 patients. Gross residual disease (>2 cm) was present in 13 patients. The most common cell types were dysgerminoma—5, endodermal sinus tumour—5, immature teratoma—5, choriocarcinoma and mixed germ cell tumour in one patient each. Twelve patients (70.5%) achieved significant response; complete response—11, partial response in one patient. The common side effects of CT were nausea/vomiting, myelosuppression, fever, mucositis, diarrhoea and alopecia. One patient died due to CT toxicity. Three complete responders underwent second look surgery and were found free of disease.This study confirms that PVB is an effective combination in the treatment of ad‐vancecd and recurrent germ cell tumours of ovary and can be given over brief period. The toxicity of the regimen is moderate.
The Value of Transabdominal Pelvic Ultrasonography in Monitoring of Ovulation Induction with Gonadotropins
Authors: Chan Yuen‐Fai , So William W. K. , Ho Pak‐Chung , Tang Grace W. K. 
Published: August 2010

AbstractSeventy‐five patients with a total of 306 human menopausal gonadotropin treatment cycles over the period 1984–1989 were analysed retrospectively to evaluate the value of transabdominal pelvic ultrasonography in prevention of complications arising from ovulation induction with human menopausal gonadotropins. There were 60 pregnancies giving a pregnancy rate of 19.6% per cycle. There was positive correlation between the number of follicles ≥ 14 mm in mean diameter and the incidence and degree of hyperstimulation (p<0.005) as well as the incidence of multiple pregnancies (p<0.01). Ultrasonography is a useful adjunct for monitoring in such a program.